EventType ThemeGene CauseGene PMID EventId Negative_regulation AANAT TNF 22347798 2011759 Negative_regulation AANAT TNF 22654792 875824 Negative_regulation AANAT TNF 22654792 875831 Negative_regulation AANAT TNF 22768337 2660827 Negative_regulation ABCA1 FAS 15869703 2112246 Negative_regulation ABCA1 TNF 21988829 1723916 Negative_regulation ABCA4 CA9 23316475 941765 Negative_regulation ABCA4 KLK3 25206322 932971 Negative_regulation ABCB1 ABCG2 22545122 2623435 Negative_regulation ABCB1 CLU 25138053 2198215 Negative_regulation ABCB1 TNFSF10 25276252 3085794 Negative_regulation ABCB11 ALOX5 25444678 590470 Negative_regulation ABCB11 TNF 24333169 1769654 Negative_regulation ABCC1 EPHB2 22787275 1805510 Negative_regulation ABCC1 MAP2K6 23320839 482743 Negative_regulation ABCC1 SPHK1 21629665 2525379 Negative_regulation ABCC6 EPHB2 21935379 2555370 Negative_regulation ABCC6 EPHB2 21935379 2555520 Negative_regulation ABCD1 TLR7 20827314 979320 Negative_regulation ABCG2 ABCB1 22545122 2623437 Negative_regulation ABCG2 CDH1 24212798 498542 Negative_regulation ABCG2 CUL1 24625985 573260 Negative_regulation ABCG2 EGF 23009336 1867006 Negative_regulation ABCG2 EGFR 21997136 437932 Negative_regulation ABCG2 EGFR 23009336 1867016 Negative_regulation ABCG2 FOXM1 25213081 475618 Negative_regulation ABCG2 FOXM1 25213081 475621 Negative_regulation ABCG2 GLI1 21625222 2139899 Negative_regulation ABCG2 ISL1 25026296 2196413 Negative_regulation ABCG2 ISL1 25026296 2196441 Negative_regulation ABCG2 ISL2 25026296 2196412 Negative_regulation ABCG2 ISL2 25026296 2196440 Negative_regulation ABCG2 MYLIP 21701675 2531336 Negative_regulation ABCG2 MYLIP 24358977 1232714 Negative_regulation ABCG2 MYLIP 25337079 695825 Negative_regulation ABCG2 PFDN2 24625985 573261 Negative_regulation ABCG2 POLR2E 24625985 573262 Negative_regulation ABCG2 POU5F1 23984394 183608 Negative_regulation ABCG2 RUVBL1 24625985 573254 Negative_regulation ABCG2 RUVBL2 24625985 573255 Negative_regulation ABCG2 SALL4 21526180 2513913 Negative_regulation ABCG2 SKP1 24625985 573256 Negative_regulation ABCG2 SKP2 24625985 573257 Negative_regulation ABCG2 SOX2 23009336 1867025 Negative_regulation ABCG2 SOX2 23967051 2834277 Negative_regulation ABCG2 STAP1 24625985 573259 Negative_regulation ABCG2 URI1 24625985 573258 Negative_regulation ABI3 EPHB2 21223585 258396 Negative_regulation ABL1 TNFSF10 24147007 2869159 Negative_regulation ACACA FAS 23770982 17955 Negative_regulation ACACA TNF 18475533 1744271 Negative_regulation ACAN CTGF 19152120 1478387 Negative_regulation ACAN CTGF 23951098 2833418 Negative_regulation ACAN MMP28 20021645 396967 Negative_regulation ACAN MMP7 20021645 396982 Negative_regulation ACAN TNF 18182117 109790 Negative_regulation ACAN TNF 22455954 125286 Negative_regulation ACD EPHB2 23360994 1934894 Negative_regulation ACD FOXO1 23906066 700753 Negative_regulation ACE ANGPT1 23552514 1035954 Negative_regulation ACE ARSA 16674817 274398 Negative_regulation ACE ARSA 21751053 1606860 Negative_regulation ACE ARSA 23675181 1064592 Negative_regulation ACHE FAS 24381529 684797 Negative_regulation ACHE PDLIM3 22205996 2584045 Negative_regulation ACHE TNF 22779027 1053004 Negative_regulation ACKR3 ID1 24256728 1991156 Negative_regulation ACKR3 TLR7 22745793 2656563 Negative_regulation ACO1 EPHB2 21887333 2549341 Negative_regulation ACSS1 CRAT 22739248 1993350 Negative_regulation ACSS1 INS 22275878 2328899 Negative_regulation ACSS2 ARSA 23843037 506271 Negative_regulation ACTR1A IFI27 23589491 1404455 Negative_regulation ADAM10 S100A7 19159013 2404517 Negative_regulation ADAM11 TLR7 21912648 2552520 Negative_regulation ADAM17 EPHB2 24130797 2866937 Negative_regulation ADAM17 TNF 17428319 356741 Negative_regulation ADAM17 TNF 17428319 356742 Negative_regulation ADAM17 TNF 17428319 356743 Negative_regulation ADAM17 TNF 25414771 206653 Negative_regulation ADAM2 ITGA9 21060781 2480793 Negative_regulation ADAMTS1 ADAMTS4 24275094 1054262 Negative_regulation ADAMTS1 CRK 24275094 1054208 Negative_regulation ADAMTS1 EZH2 22514714 2619956 Negative_regulation ADAMTS1 HDAC1 15899037 103451 Negative_regulation ADAMTS1 HDAC2 15899037 103452 Negative_regulation ADAMTS1 HIST1H3H 22514714 2619957 Negative_regulation ADAMTS1 IL1A 16919164 106571 Negative_regulation ADAMTS1 IL1A 18387286 1731643 Negative_regulation ADAMTS1 IL1A 20619343 1731691 Negative_regulation ADAMTS1 IL1A 20619343 1731739 Negative_regulation ADAMTS1 IL1A 25228841 1712835 Negative_regulation ADAMTS1 IL33 24275094 1054203 Negative_regulation ADAMTS1 IL33 24275094 1054204 Negative_regulation ADAMTS1 IL33 24275094 1054205 Negative_regulation ADAMTS1 IL33 24275094 1054206 Negative_regulation ADAMTS1 IL33 24275094 1054207 Negative_regulation ADAMTS1 IL33 24275094 1054252 Negative_regulation ADAMTS1 JUN 24275094 1054209 Negative_regulation ADAMTS1 MAPK1 24275094 1054210 Negative_regulation ADAMTS1 MAPK3 24275094 1054211 Negative_regulation ADAMTS1 MAPK8 24275094 1054212 Negative_regulation ADAMTS1 MAPK9 24275094 1054213 Negative_regulation ADAMTS1 OSM 16919164 106572 Negative_regulation ADAMTS1 OSM 25228841 1712836 Negative_regulation ADAMTS1 PI3 24275094 1054214 Negative_regulation ADAMTS1 PRG2 19445683 113320 Negative_regulation ADAMTS1 PRG3 19445683 113321 Negative_regulation ADAMTS1 PRG4 19445683 113322 Negative_regulation ADAMTS1 RBBP4 15899037 103453 Negative_regulation ADAMTS1 RBBP7 15899037 103454 Negative_regulation ADAMTS1 SMARCA4 23813473 1680857 Negative_regulation ADAMTS1 SULT2A1 24275094 1054202 Negative_regulation ADAMTS1 TIMP2 12718749 99775 Negative_regulation ADAMTS1 TIMP3 12718749 99776 Negative_regulation ADAMTS1 TIMP3 23675183 1064626 Negative_regulation ADAMTS1 TIMP3 24278441 2885924 Negative_regulation ADAMTS1 TNF 18387286 1731642 Negative_regulation ADAMTS1 VEGFA 24732590 2952156 Negative_regulation ADAMTS4 ADAMTS1 24275094 1054263 Negative_regulation ADAR NES 23982513 2092645 Negative_regulation ADCY1 CAPN8 23056924 140217 Negative_regulation ADCY1 RGS2 22802950 2663743 Negative_regulation ADCY1 S100B 23164356 1895664 Negative_regulation ADCY10 CAPN8 23056924 140203 Negative_regulation ADCY10 RGS2 22802950 2663742 Negative_regulation ADCY10 S100B 23164356 1895663 Negative_regulation ADCY2 CAPN8 23056924 140231 Negative_regulation ADCY2 RGS2 22802950 2663744 Negative_regulation ADCY2 S100B 23164356 1895665 Negative_regulation ADCY3 CAPN8 23056924 140245 Negative_regulation ADCY3 RGS2 22802950 2663745 Negative_regulation ADCY3 S100B 23164356 1895666 Negative_regulation ADCY4 CAPN8 23056924 140259 Negative_regulation ADCY4 RGS2 22802950 2663746 Negative_regulation ADCY4 S100B 23164356 1895667 Negative_regulation ADCY5 CAPN8 23056924 140273 Negative_regulation ADCY5 RGS2 22802950 2663747 Negative_regulation ADCY5 S100B 23164356 1895668 Negative_regulation ADCY6 CAPN8 23056924 140287 Negative_regulation ADCY6 RGS2 22802950 2663748 Negative_regulation ADCY6 S100B 23164356 1895669 Negative_regulation ADCY7 CAPN8 23056924 140301 Negative_regulation ADCY7 RGS2 22802950 2663749 Negative_regulation ADCY7 S100B 23164356 1895670 Negative_regulation ADCY8 CAPN8 23056924 140315 Negative_regulation ADCY8 RGS2 22802950 2663750 Negative_regulation ADCY8 S100B 23164356 1895671 Negative_regulation ADCY9 CAPN8 23056924 140329 Negative_regulation ADCY9 RGS2 22802950 2663751 Negative_regulation ADCY9 S100B 23164356 1895672 Negative_regulation ADH1A ADH1C 20617019 1075637 Negative_regulation ADH1C ADH1A 20617019 1075638 Negative_regulation ADH1C ZC3HAV1 18673560 323971 Negative_regulation ADH1C ZC3HAV1 18673560 323972 Negative_regulation ADH1C ZC3HAV1 23565060 2282526 Negative_regulation ADH4 CA12 944701 1465991 Negative_regulation ADH5 CA12 944701 1466005 Negative_regulation ADH6 CA12 944701 1466019 Negative_regulation ADH7 CA12 944701 1466033 Negative_regulation ADIPOQ TNF 19223612 729169 Negative_regulation ADIPOQ TNF 19875582 729351 Negative_regulation ADIPOQ TNF 20508825 1747458 Negative_regulation ADIPOQ TNF 21274300 1492162 Negative_regulation ADIPOQ TNF 21941676 1082280 Negative_regulation ADIPOQ TNF 21988829 1723921 Negative_regulation ADIPOQ TNF 22293775 1886005 Negative_regulation ADIPOQ TNF 22293775 1886008 Negative_regulation ADIPOQ TNF 22293775 1886009 Negative_regulation ADIPOQ TNF 22479202 2334385 Negative_regulation ADIPOQ TNF 22960344 737336 Negative_regulation ADIPOQ TNF 23251142 3076083 Negative_regulation ADIPOQ TNF 23259700 292698 Negative_regulation ADIPOQ TNF 23275933 730652 Negative_regulation ADIPOQ TNF 23381555 1140569 Negative_regulation ADIPOQ TNF 23381555 1140570 Negative_regulation ADIPOQ TNF 23381555 1140571 Negative_regulation ADIPOQ TNF 23381555 1140572 Negative_regulation ADIPOQ TNF 23381555 1140575 Negative_regulation ADIPOQ TNF 23381555 1140585 Negative_regulation ADIPOQ TNF 23381555 1140586 Negative_regulation ADIPOQ TNF 23864804 1712138 Negative_regulation ADIPOQ TNF 23864804 1712153 Negative_regulation ADIPOQ TNF 23919592 389874 Negative_regulation ADIPOQ TNF 24224162 184848 Negative_regulation ADIPOQ TNF 24455420 1152548 Negative_regulation ADIPOQ TNF 24466027 2912128 Negative_regulation ADIPOQ TNF 24886049 412611 Negative_regulation ADIPOQ TNF 25191587 1670076 Negative_regulation ADIPOQ TNF 25593737 1150295 Negative_regulation ADO NT5E 18404494 3088378 Negative_regulation ADRB2 EZH2 21532618 2139349 Negative_regulation ADRB2 IL13 20470412 396226 Negative_regulation ADRB2 IL13 20470412 396228 Negative_regulation ADRB2 NPY 20214824 328611 Negative_regulation ADRBK1 MIP 24465168 1085051 Negative_regulation AGER EPHB2 22449800 1718308 Negative_regulation AGER EPHB2 22449800 1718312 Negative_regulation AGER EPHB2 22449800 1718313 Negative_regulation AGR2 ADIPOQ 23861690 1156425 Negative_regulation AGR2 AIS1 22277572 469735 Negative_regulation AGR2 AIS2 22277572 469736 Negative_regulation AGR2 AIS3 22277572 469737 Negative_regulation AGR2 CDKN1A 8228821 1594584 Negative_regulation AGR2 CTNNB1 23213543 1718880 Negative_regulation AGR2 HDAC8 25011684 1508192 Negative_regulation AGR2 MED1 22496652 3056157 Negative_regulation AGR2 RASA1 8228821 1594585 Negative_regulation AGR2 SMAD4 22945649 2148399 Negative_regulation AGRP FOXO1 23462798 733736 Negative_regulation AGT TNF 24058780 1705522 Negative_regulation AGT TNF 24058780 1705560 Negative_regulation AGTR1 TNF 21884646 659994 Negative_regulation AGTR1 TNF 24391675 825078 Negative_regulation AGTR2 ID1 23304450 1080090 Negative_regulation AGTR2 TNF 20069129 1213493 Negative_regulation AHR EPHB2 24527405 136000 Negative_regulation AHR FAS 16618792 1540103 Negative_regulation AHR FAS 16618792 1540104 Negative_regulation AHR FAS 16618792 1540105 Negative_regulation AHR MUC16 19996156 811673 Negative_regulation AHR RGS2 25197168 1761997 Negative_regulation AHR SELL 21437035 1162381 Negative_regulation AHR SPON2 21684833 794397 Negative_regulation AHR STAT4 25045206 1760110 Negative_regulation AHR TNF 19707336 175516 Negative_regulation AHR TNF 21298084 2320958 Negative_regulation AHR TNF 21298084 2320979 Negative_regulation AHSA1 CTGF 24312401 2889182 Negative_regulation AHSA1 EPHB2 19727076 1983897 Negative_regulation AHSA1 EPHB2 20727231 466205 Negative_regulation AHSA1 EPHB2 21739608 776467 Negative_regulation AHSA1 EPHB2 22605923 1914323 Negative_regulation AHSA1 EPHB2 22675451 2648484 Negative_regulation AHSA1 EPHB2 22860116 2671701 Negative_regulation AHSA1 EPHB2 24052942 3165900 Negative_regulation AHSA1 EPHB2 24146543 1916416 Negative_regulation AHSA1 EPHB2 25155142 1917706 Negative_regulation AHSA1 EPHB2 25299270 174401 Negative_regulation AHSA1 EPHB2 25398056 3027485 Negative_regulation AHSA1 MAP2K6 19727076 1983903 Negative_regulation AHSA1 MAP2K6 20955562 120497 Negative_regulation AHSA1 TLR7 20832340 1040215 Negative_regulation AHSA1 TNF 15175101 523604 Negative_regulation AHSA1 TNF 20676807 694236 Negative_regulation AHSA1 TNF 24386004 825044 Negative_regulation AHSA1 TNF 24495480 131699 Negative_regulation AIM2 TNF 23630667 863999 Negative_regulation AK3 CCND1 22253692 2587600 Negative_regulation AKR1B1 TNF 25126080 965772 Negative_regulation AKR1C1 CCND1 24848372 2972404 Negative_regulation AKR1C3 CCND1 24848372 2972405 Negative_regulation AKT1 ALOX5 24844534 1651487 Negative_regulation AKT1 ANGPT1 22558265 2624914 Negative_regulation AKT1 ANGPT1 23554782 1226174 Negative_regulation AKT1 ANGPT1 23554782 1226186 Negative_regulation AKT1 ANGPT1 23554782 1226193 Negative_regulation AKT1 BPI 21218173 549337 Negative_regulation AKT1 BPI 22545124 2623468 Negative_regulation AKT1 CAPN8 23425388 275253 Negative_regulation AKT1 CAPN8 23425388 275347 Negative_regulation AKT1 CAPN8 23425388 275603 Negative_regulation AKT1 CAPN8 23425388 275856 Negative_regulation AKT1 CCND1 24330780 1870590 Negative_regulation AKT1 CCND1 24955027 680105 Negative_regulation AKT1 CEACAM6 25398131 3027597 Negative_regulation AKT1 CHI3L1 23972995 608944 Negative_regulation AKT1 CTGF 19152120 1478368 Negative_regulation AKT1 CTGF 19707545 2424404 Negative_regulation AKT1 CTGF 25368602 881327 Negative_regulation AKT1 EPHB2 11121444 1265873 Negative_regulation AKT1 EPHB2 18091994 2381400 Negative_regulation AKT1 EPHB2 19522012 3170525 Negative_regulation AKT1 EPHB2 20195469 2441832 Negative_regulation AKT1 EPHB2 21048967 2480312 Negative_regulation AKT1 EPHB2 21048967 2480318 Negative_regulation AKT1 EPHB2 22293957 1086463 Negative_regulation AKT1 EPHB2 22312244 1094809 Negative_regulation AKT1 EPHB2 22384148 2606711 Negative_regulation AKT1 EPHB2 22649371 874829 Negative_regulation AKT1 EPHB2 22701710 2652052 Negative_regulation AKT1 EPHB2 22777356 2147981 Negative_regulation AKT1 EPHB2 23211542 2181805 Negative_regulation AKT1 EPHB2 24155779 1240245 Negative_regulation AKT1 EPHB2 24391468 2285148 Negative_regulation AKT1 EPHB2 24533454 271662 Negative_regulation AKT1 EPHB2 24551245 2923432 Negative_regulation AKT1 EPHB2 24797725 2189709 Negative_regulation AKT1 EPHB2 24972137 1127947 Negative_regulation AKT1 EPHB2 25312253 3146135 Negative_regulation AKT1 EPHB2 25421240 1135056 Negative_regulation AKT1 EPHB2 25431423 741609 Negative_regulation AKT1 EPHB2 25431423 741617 Negative_regulation AKT1 EPHB2 25530619 1136255 Negative_regulation AKT1 FAS 11121444 1265866 Negative_regulation AKT1 FAS 18782442 111167 Negative_regulation AKT1 FAS 24999379 2229539 Negative_regulation AKT1 FBXO32 24765525 847692 Negative_regulation AKT1 FHL1 24952875 274104 Negative_regulation AKT1 FHL1 24952875 274114 Negative_regulation AKT1 FOXO1 18355401 1646184 Negative_regulation AKT1 FOXO1 20642839 1647295 Negative_regulation AKT1 FOXO1 21980390 2560025 Negative_regulation AKT1 FOXO1 21980390 2560162 Negative_regulation AKT1 FOXO1 22312004 1395078 Negative_regulation AKT1 FOXO1 22888331 903126 Negative_regulation AKT1 FOXO1 24062690 962236 Negative_regulation AKT1 FOXO1 25321482 578510 Negative_regulation AKT1 HBEGF 22792252 2661635 Negative_regulation AKT1 HBEGF 22984591 2689342 Negative_regulation AKT1 IFI27 16780593 579972 Negative_regulation AKT1 IFI27 23471028 1637686 Negative_regulation AKT1 INPP4B 21487159 2175784 Negative_regulation AKT1 INPP4B 25126743 2997983 Negative_regulation AKT1 INPP4B 25126743 2997984 Negative_regulation AKT1 INPP4B 25126743 2997998 Negative_regulation AKT1 INPP4B 25542038 3036096 Negative_regulation AKT1 KANK4 18458160 1351871 Negative_regulation AKT1 MAP2K6 20383279 2445499 Negative_regulation AKT1 MAP2K6 20383279 2445620 Negative_regulation AKT1 MAP2K6 21666717 2140141 Negative_regulation AKT1 MAP2K6 21666717 2140162 Negative_regulation AKT1 MAP2K6 22649371 874835 Negative_regulation AKT1 MAP2K6 22649371 874923 Negative_regulation AKT1 MAP2K6 22880048 2673629 Negative_regulation AKT1 MAP2K6 22880048 2673739 Negative_regulation AKT1 MAP2K6 23524590 218379 Negative_regulation AKT1 MAP2K6 24475138 2914880 Negative_regulation AKT1 MAP2K6 24970815 2194050 Negative_regulation AKT1 MAP2K6 24970815 2194051 Negative_regulation AKT1 MAP2K6 24970815 2194304 Negative_regulation AKT1 MAP2K6 24970815 2194366 Negative_regulation AKT1 RCAN1 19124655 1553318 Negative_regulation AKT1 SCGB3A1 21812955 260671 Negative_regulation AKT1 SPHK1 19956567 2432075 Negative_regulation AKT1 STK39 25105148 196044 Negative_regulation AKT1 TCN1 19668232 2126321 Negative_regulation AKT1 TCN1 20489726 546888 Negative_regulation AKT1 TCN1 20489726 546889 Negative_regulation AKT1 TCN1 20489726 546890 Negative_regulation AKT1 TCN1 20489726 546891 Negative_regulation AKT1 TCN1 20489726 546892 Negative_regulation AKT1 TCN1 20489726 546893 Negative_regulation AKT1 TCN1 20489726 546894 Negative_regulation AKT1 TCN1 20489726 546895 Negative_regulation AKT1 TCN1 20489726 546944 Negative_regulation AKT1 TCN1 20489726 546950 Negative_regulation AKT1 TCN1 20489726 546973 Negative_regulation AKT1 TCN1 20489726 546974 Negative_regulation AKT1 TCN1 20489726 546975 Negative_regulation AKT1 TCN1 20489726 546999 Negative_regulation AKT1 TCN1 20489726 547000 Negative_regulation AKT1 TCN1 20489726 547020 Negative_regulation AKT1 TCN1 20489726 547032 Negative_regulation AKT1 TCN1 22276165 2590260 Negative_regulation AKT1 TCN1 22590527 2640973 Negative_regulation AKT1 TCN1 22590527 2640999 Negative_regulation AKT1 TCN1 22590527 2641011 Negative_regulation AKT1 TCN1 23469174 2762563 Negative_regulation AKT1 TCN1 23977176 2838807 Negative_regulation AKT1 TCN1 23977176 2838813 Negative_regulation AKT1 TLR7 24367261 3065370 Negative_regulation AKT1 TLR7 24740015 2953896 Negative_regulation AKT1 TNF 19343194 2290471 Negative_regulation AKT1 TNF 19709445 1625571 Negative_regulation AKT1 TNF 21773023 1669801 Negative_regulation AKT1 TNF 22973882 1895460 Negative_regulation AKT1 TNF 23071583 2703122 Negative_regulation AKT1 TNF 23800251 1627046 Negative_regulation AKT1 TNF PMC3272755 99492 Negative_regulation AKT1 TNFSF10 23091403 3129162 Negative_regulation AKT1 TNFSF10 25000265 1128277 Negative_regulation AKT1 WIF1 20573255 1856514 Negative_regulation AKT1S1 FAS 18776140 706724 Negative_regulation AKT1S1 FOXO1 23800068 830165 Negative_regulation AKT2 ALOX5 24844534 1651488 Negative_regulation AKT2 ANGPT1 22558265 2624915 Negative_regulation AKT2 ANGPT1 23554782 1226175 Negative_regulation AKT2 ANGPT1 23554782 1226187 Negative_regulation AKT2 ANGPT1 23554782 1226194 Negative_regulation AKT2 BPI 21218173 549338 Negative_regulation AKT2 BPI 22545124 2623469 Negative_regulation AKT2 CAPN8 23425388 275267 Negative_regulation AKT2 CAPN8 23425388 275362 Negative_regulation AKT2 CAPN8 23425388 275618 Negative_regulation AKT2 CAPN8 23425388 275870 Negative_regulation AKT2 CCND1 24330780 1870592 Negative_regulation AKT2 CCND1 24955027 680107 Negative_regulation AKT2 CEACAM6 25398131 3027598 Negative_regulation AKT2 CHI3L1 23972995 608945 Negative_regulation AKT2 CTGF 19152120 1478369 Negative_regulation AKT2 CTGF 19707545 2424405 Negative_regulation AKT2 CTGF 25368602 881328 Negative_regulation AKT2 EPHB2 11121444 1265874 Negative_regulation AKT2 EPHB2 18091994 2381401 Negative_regulation AKT2 EPHB2 19522012 3170526 Negative_regulation AKT2 EPHB2 20195469 2441833 Negative_regulation AKT2 EPHB2 21048967 2480313 Negative_regulation AKT2 EPHB2 21048967 2480319 Negative_regulation AKT2 EPHB2 22293957 1086465 Negative_regulation AKT2 EPHB2 22312244 1094812 Negative_regulation AKT2 EPHB2 22384148 2606727 Negative_regulation AKT2 EPHB2 22649371 874838 Negative_regulation AKT2 EPHB2 22701710 2652053 Negative_regulation AKT2 EPHB2 22777356 2147984 Negative_regulation AKT2 EPHB2 23211542 2181807 Negative_regulation AKT2 EPHB2 24155779 1240247 Negative_regulation AKT2 EPHB2 24391468 2285149 Negative_regulation AKT2 EPHB2 24533454 271663 Negative_regulation AKT2 EPHB2 24551245 2923434 Negative_regulation AKT2 EPHB2 24797725 2189710 Negative_regulation AKT2 EPHB2 24972137 1127962 Negative_regulation AKT2 EPHB2 25312253 3146138 Negative_regulation AKT2 EPHB2 25421240 1135058 Negative_regulation AKT2 EPHB2 25431423 741610 Negative_regulation AKT2 EPHB2 25431423 741618 Negative_regulation AKT2 EPHB2 25530619 1136256 Negative_regulation AKT2 FAS 11121444 1265867 Negative_regulation AKT2 FAS 18782442 111169 Negative_regulation AKT2 FAS 24999379 2229540 Negative_regulation AKT2 FBXO32 24765525 847694 Negative_regulation AKT2 FHL1 24952875 274105 Negative_regulation AKT2 FHL1 24952875 274115 Negative_regulation AKT2 FOXO1 18355401 1646188 Negative_regulation AKT2 FOXO1 20642839 1647299 Negative_regulation AKT2 FOXO1 21980390 2560029 Negative_regulation AKT2 FOXO1 21980390 2560166 Negative_regulation AKT2 FOXO1 22312004 1395082 Negative_regulation AKT2 FOXO1 22888331 903130 Negative_regulation AKT2 FOXO1 25321482 578514 Negative_regulation AKT2 HBEGF 22792252 2661636 Negative_regulation AKT2 HBEGF 22984591 2689343 Negative_regulation AKT2 IFI27 23471028 1637688 Negative_regulation AKT2 INPP4B 21487159 2175785 Negative_regulation AKT2 INPP4B 25126743 2997985 Negative_regulation AKT2 INPP4B 25126743 2997986 Negative_regulation AKT2 INPP4B 25126743 2997999 Negative_regulation AKT2 INPP4B 25542038 3036098 Negative_regulation AKT2 KANK4 18458160 1351875 Negative_regulation AKT2 MAP2K6 20383279 2445511 Negative_regulation AKT2 MAP2K6 20383279 2445627 Negative_regulation AKT2 MAP2K6 21666717 2140148 Negative_regulation AKT2 MAP2K6 21666717 2140169 Negative_regulation AKT2 MAP2K6 22649371 874844 Negative_regulation AKT2 MAP2K6 22649371 874930 Negative_regulation AKT2 MAP2K6 22880048 2673636 Negative_regulation AKT2 MAP2K6 22880048 2673746 Negative_regulation AKT2 MAP2K6 23524590 218386 Negative_regulation AKT2 MAP2K6 24475138 2914887 Negative_regulation AKT2 MAP2K6 24970815 2194064 Negative_regulation AKT2 MAP2K6 24970815 2194065 Negative_regulation AKT2 MAP2K6 24970815 2194311 Negative_regulation AKT2 MAP2K6 24970815 2194373 Negative_regulation AKT2 MMP28 21960994 831890 Negative_regulation AKT2 MMP7 21960994 831905 Negative_regulation AKT2 RCAN1 19124655 1553319 Negative_regulation AKT2 SCGB3A1 21812955 260672 Negative_regulation AKT2 SPHK1 19956567 2432076 Negative_regulation AKT2 STK39 25105148 196059 Negative_regulation AKT2 TCN1 19668232 2126323 Negative_regulation AKT2 TCN1 20489726 546904 Negative_regulation AKT2 TCN1 20489726 546905 Negative_regulation AKT2 TCN1 20489726 546906 Negative_regulation AKT2 TCN1 20489726 546907 Negative_regulation AKT2 TCN1 20489726 546908 Negative_regulation AKT2 TCN1 20489726 546909 Negative_regulation AKT2 TCN1 20489726 546910 Negative_regulation AKT2 TCN1 20489726 546911 Negative_regulation AKT2 TCN1 20489726 546946 Negative_regulation AKT2 TCN1 20489726 546952 Negative_regulation AKT2 TCN1 20489726 546979 Negative_regulation AKT2 TCN1 20489726 546980 Negative_regulation AKT2 TCN1 20489726 546981 Negative_regulation AKT2 TCN1 20489726 547003 Negative_regulation AKT2 TCN1 20489726 547004 Negative_regulation AKT2 TCN1 20489726 547022 Negative_regulation AKT2 TCN1 20489726 547034 Negative_regulation AKT2 TCN1 22276165 2590262 Negative_regulation AKT2 TCN1 22590527 2640976 Negative_regulation AKT2 TCN1 22590527 2641003 Negative_regulation AKT2 TCN1 22590527 2641014 Negative_regulation AKT2 TCN1 23469174 2762565 Negative_regulation AKT2 TCN1 23977176 2838809 Negative_regulation AKT2 TCN1 23977176 2838815 Negative_regulation AKT2 TLR7 24367261 3065380 Negative_regulation AKT2 TLR7 24740015 2953906 Negative_regulation AKT2 TNF 19343194 2290472 Negative_regulation AKT2 TNF 19709445 1625573 Negative_regulation AKT2 TNF 21773023 1669802 Negative_regulation AKT2 TNF 22973882 1895461 Negative_regulation AKT2 TNF 23071583 2703123 Negative_regulation AKT2 TNF 23800251 1627047 Negative_regulation AKT2 TNF PMC3272755 99493 Negative_regulation AKT2 TNFSF10 23091403 3129165 Negative_regulation AKT2 TNFSF10 25000265 1128278 Negative_regulation AKT2 WIF1 20573255 1856515 Negative_regulation AKT3 ALOX5 24844534 1651489 Negative_regulation AKT3 ANGPT1 22558265 2624916 Negative_regulation AKT3 ANGPT1 23554782 1226176 Negative_regulation AKT3 ANGPT1 23554782 1226188 Negative_regulation AKT3 ANGPT1 23554782 1226195 Negative_regulation AKT3 BPI 21218173 549339 Negative_regulation AKT3 BPI 22545124 2623470 Negative_regulation AKT3 CAPN8 23425388 275281 Negative_regulation AKT3 CAPN8 23425388 275377 Negative_regulation AKT3 CAPN8 23425388 275633 Negative_regulation AKT3 CAPN8 23425388 275884 Negative_regulation AKT3 CCND1 24330780 1870594 Negative_regulation AKT3 CCND1 24955027 680109 Negative_regulation AKT3 CEACAM6 25398131 3027599 Negative_regulation AKT3 CHI3L1 23972995 608946 Negative_regulation AKT3 CTGF 19152120 1478370 Negative_regulation AKT3 CTGF 19707545 2424406 Negative_regulation AKT3 CTGF 25368602 881329 Negative_regulation AKT3 EPHB2 11121444 1265875 Negative_regulation AKT3 EPHB2 18091994 2381402 Negative_regulation AKT3 EPHB2 19522012 3170527 Negative_regulation AKT3 EPHB2 20195469 2441834 Negative_regulation AKT3 EPHB2 21048967 2480314 Negative_regulation AKT3 EPHB2 21048967 2480320 Negative_regulation AKT3 EPHB2 22293957 1086467 Negative_regulation AKT3 EPHB2 22312244 1094815 Negative_regulation AKT3 EPHB2 22384148 2606743 Negative_regulation AKT3 EPHB2 22649371 874847 Negative_regulation AKT3 EPHB2 22701710 2652054 Negative_regulation AKT3 EPHB2 22777356 2147987 Negative_regulation AKT3 EPHB2 23211542 2181809 Negative_regulation AKT3 EPHB2 24155779 1240249 Negative_regulation AKT3 EPHB2 24391468 2285150 Negative_regulation AKT3 EPHB2 24533454 271664 Negative_regulation AKT3 EPHB2 24551245 2923436 Negative_regulation AKT3 EPHB2 24797725 2189711 Negative_regulation AKT3 EPHB2 24972137 1127977 Negative_regulation AKT3 EPHB2 25312253 3146141 Negative_regulation AKT3 EPHB2 25421240 1135060 Negative_regulation AKT3 EPHB2 25431423 741611 Negative_regulation AKT3 EPHB2 25431423 741619 Negative_regulation AKT3 EPHB2 25530619 1136257 Negative_regulation AKT3 FAS 11121444 1265868 Negative_regulation AKT3 FAS 18782442 111171 Negative_regulation AKT3 FAS 24999379 2229541 Negative_regulation AKT3 FBXO32 24765525 847696 Negative_regulation AKT3 FHL1 24952875 274106 Negative_regulation AKT3 FHL1 24952875 274116 Negative_regulation AKT3 FOXO1 18355401 1646192 Negative_regulation AKT3 FOXO1 20642839 1647303 Negative_regulation AKT3 FOXO1 21980390 2560033 Negative_regulation AKT3 FOXO1 21980390 2560170 Negative_regulation AKT3 FOXO1 22312004 1395086 Negative_regulation AKT3 FOXO1 22888331 903134 Negative_regulation AKT3 FOXO1 25321482 578518 Negative_regulation AKT3 HBEGF 22792252 2661637 Negative_regulation AKT3 HBEGF 22984591 2689344 Negative_regulation AKT3 IFI27 23471028 1637690 Negative_regulation AKT3 INPP4B 21487159 2175786 Negative_regulation AKT3 INPP4B 25126743 2997987 Negative_regulation AKT3 INPP4B 25126743 2997988 Negative_regulation AKT3 INPP4B 25126743 2998000 Negative_regulation AKT3 INPP4B 25542038 3036100 Negative_regulation AKT3 KANK4 18458160 1351879 Negative_regulation AKT3 MAP2K6 20383279 2445523 Negative_regulation AKT3 MAP2K6 20383279 2445634 Negative_regulation AKT3 MAP2K6 21666717 2140155 Negative_regulation AKT3 MAP2K6 21666717 2140176 Negative_regulation AKT3 MAP2K6 22649371 874853 Negative_regulation AKT3 MAP2K6 22649371 874937 Negative_regulation AKT3 MAP2K6 22880048 2673643 Negative_regulation AKT3 MAP2K6 22880048 2673753 Negative_regulation AKT3 MAP2K6 23524590 218393 Negative_regulation AKT3 MAP2K6 24475138 2914894 Negative_regulation AKT3 MAP2K6 24970815 2194078 Negative_regulation AKT3 MAP2K6 24970815 2194079 Negative_regulation AKT3 MAP2K6 24970815 2194318 Negative_regulation AKT3 MAP2K6 24970815 2194380 Negative_regulation AKT3 RCAN1 19124655 1553320 Negative_regulation AKT3 SCGB3A1 21812955 260673 Negative_regulation AKT3 SPHK1 19956567 2432077 Negative_regulation AKT3 STK39 25105148 196074 Negative_regulation AKT3 TCN1 19668232 2126325 Negative_regulation AKT3 TCN1 20489726 546920 Negative_regulation AKT3 TCN1 20489726 546921 Negative_regulation AKT3 TCN1 20489726 546922 Negative_regulation AKT3 TCN1 20489726 546923 Negative_regulation AKT3 TCN1 20489726 546924 Negative_regulation AKT3 TCN1 20489726 546925 Negative_regulation AKT3 TCN1 20489726 546926 Negative_regulation AKT3 TCN1 20489726 546927 Negative_regulation AKT3 TCN1 20489726 546948 Negative_regulation AKT3 TCN1 20489726 546954 Negative_regulation AKT3 TCN1 20489726 546985 Negative_regulation AKT3 TCN1 20489726 546986 Negative_regulation AKT3 TCN1 20489726 546987 Negative_regulation AKT3 TCN1 20489726 547007 Negative_regulation AKT3 TCN1 20489726 547008 Negative_regulation AKT3 TCN1 20489726 547024 Negative_regulation AKT3 TCN1 20489726 547036 Negative_regulation AKT3 TCN1 22276165 2590264 Negative_regulation AKT3 TCN1 22590527 2640979 Negative_regulation AKT3 TCN1 22590527 2641007 Negative_regulation AKT3 TCN1 22590527 2641017 Negative_regulation AKT3 TCN1 23469174 2762567 Negative_regulation AKT3 TCN1 23977176 2838811 Negative_regulation AKT3 TCN1 23977176 2838817 Negative_regulation AKT3 TLR7 24367261 3065390 Negative_regulation AKT3 TLR7 24740015 2953916 Negative_regulation AKT3 TNF 19343194 2290473 Negative_regulation AKT3 TNF 19709445 1625575 Negative_regulation AKT3 TNF 21773023 1669803 Negative_regulation AKT3 TNF 22973882 1895462 Negative_regulation AKT3 TNF 23071583 2703124 Negative_regulation AKT3 TNF 23800251 1627048 Negative_regulation AKT3 TNF PMC3272755 99494 Negative_regulation AKT3 TNFSF10 23091403 3129168 Negative_regulation AKT3 TNFSF10 25000265 1128279 Negative_regulation AKT3 WIF1 20573255 1856516 Negative_regulation ALB CA12 19116015 1767948 Negative_regulation ALB CA12 23443105 1102554 Negative_regulation ALB CA12 944701 1466047 Negative_regulation ALB TNF 24718309 2950818 Negative_regulation ALDH1A2 EPHB2 19252500 1960629 Negative_regulation ALDH2 PTMS 25465468 3094896 Negative_regulation ALOX5 AKT1 24844534 1651490 Negative_regulation ALOX5 AKT2 24844534 1651491 Negative_regulation ALOX5 AKT3 24844534 1651492 Negative_regulation ALOX5 ALOX5AP 1469057 1302689 Negative_regulation ALOX5 ALOX5AP 18475524 1744198 Negative_regulation ALOX5 ALOX5AP 8245774 1594724 Negative_regulation ALOX5 CYSLTR1 PMC4033953 2245794 Negative_regulation ALOX5 GPX1 22216095 2584391 Negative_regulation ALOX5 HDAC1 23093607 2081828 Negative_regulation ALOX5 HDAC1 25402609 2160652 Negative_regulation ALOX5 HDAC2 23093607 2081829 Negative_regulation ALOX5 HDAC2 25402609 2160653 Negative_regulation ALOX5 KMT2A 25402609 2160721 Negative_regulation ALOX5 MMP3 21060724 1084117 Negative_regulation ALOX5 PLA2G4A 23015755 1807712 Negative_regulation ALOX5 PRDX2 23599172 2183049 Negative_regulation ALOX5 PTGS1 23770053 1498338 Negative_regulation ALOX5 PTGS2 17156456 107700 Negative_regulation ALOX5 PTGS2 22785226 1918950 Negative_regulation ALOX5 PTGS2 24064666 1920007 Negative_regulation ALOX5 RBBP4 23093607 2081830 Negative_regulation ALOX5 RBBP4 25402609 2160654 Negative_regulation ALOX5 RBBP7 23093607 2081831 Negative_regulation ALOX5 RBBP7 25402609 2160655 Negative_regulation ALOX5 RBL1 1469057 1302679 Negative_regulation ALOX5 RBL2 1469057 1302680 Negative_regulation ALOX5 TLR4 25116953 2996581 Negative_regulation ALOX5 TLR4 25116953 2996587 Negative_regulation ALOX5 TLR4 25116953 2996593 Negative_regulation ALOX5 TNF 23145181 2716261 Negative_regulation ALOX5 UGCG 19497113 113471 Negative_regulation ALPI EPHB2 23831571 2152778 Negative_regulation ALS3 RAB31 22848547 2669700 Negative_regulation AMH STK39 24053599 628688 Negative_regulation ANG ANGPT1 20805979 2471608 Negative_regulation ANGPT1 AMELX 20072701 1671832 Negative_regulation ANGPT1 AMELX 23577259 1497062 Negative_regulation ANGPT1 AMELX 24212958 499376 Negative_regulation ANGPT1 ANG 20805979 2471609 Negative_regulation ANGPT1 ANGPT1 24367525 2900125 Negative_regulation ANGPT1 ANGPT2 16611363 3096210 Negative_regulation ANGPT1 ANGPT2 17341311 279546 Negative_regulation ANGPT1 ANGPT2 19025590 659094 Negative_regulation ANGPT1 ANGPT2 19435476 659223 Negative_regulation ANGPT1 ANGPT2 19922791 613173 Negative_regulation ANGPT1 ANGPT2 20687922 855075 Negative_regulation ANGPT1 ANGPT2 21209923 2492454 Negative_regulation ANGPT1 ANGPT2 22496856 2617682 Negative_regulation ANGPT1 ANGPT2 22938389 3207769 Negative_regulation ANGPT1 ANGPT2 23734875 357377 Negative_regulation ANGPT1 ANGPT2 23826161 2810575 Negative_regulation ANGPT1 ANGPT2 24244628 2880995 Negative_regulation ANGPT1 ANGPT2 24367525 2900131 Negative_regulation ANGPT1 ANGPT2 24433482 1667540 Negative_regulation ANGPT1 ARG1 23840386 2812676 Negative_regulation ANGPT1 ARG2 23840386 2812677 Negative_regulation ANGPT1 DKK3 23765731 3080559 Negative_regulation ANGPT1 DKK3 23765731 3080575 Negative_regulation ANGPT1 DUSP1 24308939 1158554 Negative_regulation ANGPT1 DUSP10 24308939 1158555 Negative_regulation ANGPT1 DUSP11 24308939 1158556 Negative_regulation ANGPT1 DUSP12 24308939 1158557 Negative_regulation ANGPT1 DUSP13 24308939 1158549 Negative_regulation ANGPT1 DUSP14 24308939 1158545 Negative_regulation ANGPT1 DUSP15 24308939 1158544 Negative_regulation ANGPT1 DUSP16 24308939 1158546 Negative_regulation ANGPT1 DUSP18 24308939 1158547 Negative_regulation ANGPT1 DUSP19 24308939 1158548 Negative_regulation ANGPT1 DUSP2 24308939 1158558 Negative_regulation ANGPT1 DUSP21 24308939 1158550 Negative_regulation ANGPT1 DUSP22 24308939 1158543 Negative_regulation ANGPT1 DUSP23 24308939 1158551 Negative_regulation ANGPT1 DUSP26 24308939 1158553 Negative_regulation ANGPT1 DUSP27 24308939 1158552 Negative_regulation ANGPT1 DUSP28 24308939 1158566 Negative_regulation ANGPT1 DUSP3 24308939 1158559 Negative_regulation ANGPT1 DUSP4 24308939 1158560 Negative_regulation ANGPT1 DUSP5 24308939 1158561 Negative_regulation ANGPT1 DUSP5 24308939 1158918 Negative_regulation ANGPT1 DUSP6 24308939 1158562 Negative_regulation ANGPT1 DUSP7 24308939 1158563 Negative_regulation ANGPT1 DUSP8 24308939 1158564 Negative_regulation ANGPT1 DUSP9 24308939 1158565 Negative_regulation ANGPT1 EGLN1 23616286 780647 Negative_regulation ANGPT1 EGR1 24308939 1158782 Negative_regulation ANGPT1 ID1 24516656 2921361 Negative_regulation ANGPT1 IL6 19737862 1556179 Negative_regulation ANGPT1 IL6 24179334 3177087 Negative_regulation ANGPT1 JUN 24308939 1158567 Negative_regulation ANGPT1 KDR 20224655 1672016 Negative_regulation ANGPT1 MRXS5 12956885 3095072 Negative_regulation ANGPT1 MSC 20554518 1188171 Negative_regulation ANGPT1 PI3 24308939 1158919 Negative_regulation ANGPT1 PIK3C3 24642125 614210 Negative_regulation ANGPT1 PIK3CA 23765731 3080560 Negative_regulation ANGPT1 PIK3R1 23765731 3080561 Negative_regulation ANGPT1 PIK3R4 24642125 614211 Negative_regulation ANGPT1 PTPN6 22454630 832610 Negative_regulation ANGPT1 REG1A 22454630 832611 Negative_regulation ANGPT1 TIE1 19922791 613198 Negative_regulation ANGPT1 TIE1 19922791 613246 Negative_regulation ANGPT1 TIE1 23036162 660351 Negative_regulation ANGPT1 TIE1 23405099 2751799 Negative_regulation ANGPT1 TIE1 24308939 1158781 Negative_regulation ANGPT1 TIMP1 25412260 3029085 Negative_regulation ANGPT1 TIMP3 22792187 2661224 Negative_regulation ANGPT1 VDR 24084056 2118311 Negative_regulation ANGPT1 ZNF350 23991171 2841245 Negative_regulation ANGPT2 ANGPT1 19435476 659197 Negative_regulation ANGPT2 ANGPT1 22792187 2661188 Negative_regulation ANGPT2 ANGPT1 23049737 2699241 Negative_regulation ANGPT2 ANGPT1 23734875 357378 Negative_regulation ANGPT2 ANGPT1 24367525 2900126 Negative_regulation ANGPT2 ANGPT1 24433482 1667542 Negative_regulation ANGPT2 ANGPT1 24760505 2251939 Negative_regulation ANGPT2 ANKRD1 25089522 2994521 Negative_regulation ANGPT2 CCND1 20037604 8687 Negative_regulation ANGPT2 CLU 25148511 3002014 Negative_regulation ANGPT2 CLU 25148511 3002015 Negative_regulation ANGPT2 ID1 24516656 2921359 Negative_regulation ANGPT2 MMP28 22792188 2661235 Negative_regulation ANGPT2 MMP7 22792188 2661250 Negative_regulation ANGPT2 TNF 25125485 505190 Negative_regulation ANGPT4 ANGPT1 24367525 2900127 Negative_regulation ANK1 EPHB2 24023801 2843562 Negative_regulation ANK1 NFASC 8947556 1458121 Negative_regulation ANK2 EPHB2 24023801 2843564 Negative_regulation ANK2 NFASC 8947556 1458122 Negative_regulation ANK3 CAPN8 24155982 2871968 Negative_regulation ANK3 EPHB2 24023801 2843566 Negative_regulation ANK3 NFASC 8947556 1458123 Negative_regulation ANO1 CALM3 21642943 12812 Negative_regulation ANO1 CALM3 24420770 1611197 Negative_regulation ANO1 EPHB2 24639373 492638 Negative_regulation ANO1 MAP2K1 24639373 492639 Negative_regulation ANO1 MAP2K2 24639373 492640 Negative_regulation ANO1 MAP2K3 24639373 492641 Negative_regulation ANO1 MAP2K4 24639373 492642 Negative_regulation ANO1 MAP2K5 24639373 492643 Negative_regulation ANO1 MAP2K6 24639373 492644 Negative_regulation ANO1 MAP2K7 24639373 492645 Negative_regulation ANO1 RAF1 24639373 492646 Negative_regulation ANO1 TFP1 24420770 1611146 Negative_regulation ANO1 TFP1 24420770 1611147 Negative_regulation ANO1 TFP1 24420770 1611178 Negative_regulation ANPEP TNF 17106732 1643940 Negative_regulation ANXA1 TNF 14568984 1529234 Negative_regulation ANXA5 EPHB2 22844495 2668384 Negative_regulation ANXA5 TNF 21324111 121481 Negative_regulation ANXA5 TNF 21324111 121493 Negative_regulation ANXA6 EPHB2 22312244 1094818 Negative_regulation ANXA6 EPHB2 22537317 355849 Negative_regulation ANXA6 EPHB2 25431423 741612 Negative_regulation ANXA6 EPHB2 25431423 741620 Negative_regulation ANXA6 MAP2K6 21408212 2292318 Negative_regulation ANXA6 NES 19406170 1770203 Negative_regulation ANXA6 RAB31 23892275 18318 Negative_regulation ANXA6 TLR7 23421931 590880 Negative_regulation ANXA6 TNF 19946407 34363 Negative_regulation APC ALDH2 23468836 2759749 Negative_regulation APC ALDH2 23468836 2759752 Negative_regulation APC AXIN2 10330403 1246279 Negative_regulation APC F2R 21834973 659980 Negative_regulation APC F2R 23739325 1990496 Negative_regulation APCS ITGB2 24376655 2901736 Negative_regulation APITD1 SMN2 17548509 1340859 Negative_regulation APLN ANGPT1 22558265 2624885 Negative_regulation APOA1 EPHB2 20102334 651182 Negative_regulation APOA1 TNF 21988829 1723914 Negative_regulation APOB FOXA1 22238690 2587072 Negative_regulation APOB MAMLD1 20523870 1047081 Negative_regulation APOB PCSK9 23135270 1205604 Negative_regulation APOB PCSK9 23580362 749004 Negative_regulation APOB PCSK9 23936445 2830937 Negative_regulation APOB PLAT 21046291 665333 Negative_regulation APOBEC3G EPHB2 19371434 3117729 Negative_regulation APOE TNF 18678613 706668 Negative_regulation APOE TNF 21772670 1749358 Negative_regulation APOE TNF 21772670 1749368 Negative_regulation APOE TNF 24244577 2880454 Negative_regulation APOE TNF 24244577 2880457 Negative_regulation APP S100B 19668572 649432 Negative_regulation APP S100B 19668572 649433 Negative_regulation APP SORL1 16930455 1890595 Negative_regulation APP SORL1 16930455 1890640 Negative_regulation APP SORL1 16930455 1890641 Negative_regulation APP SORL1 22621900 1803313 Negative_regulation APP SORL1 22727043 406264 Negative_regulation APP SORL1 22727043 406265 Negative_regulation APP TNF 22279475 1685668 Negative_regulation AQP1 TNF 24369440 1755928 Negative_regulation AQP2 EPHB2 18431594 2242541 Negative_regulation AQP3 TNF 25161869 854089 Negative_regulation AQP5 TNF 24369440 1755929 Negative_regulation AQP5 TNF 24369440 1755947 Negative_regulation AQP5 TNF 24369440 1755949 Negative_regulation AR ABCG2 23383057 2747683 Negative_regulation AR FOXO1 23130204 1043714 Negative_regulation AR FOXO1 23614736 830031 Negative_regulation AR FOXO1 24591817 742899 Negative_regulation ARAF MAP2K6 19247477 2406569 Negative_regulation ARC EPHB2 24045785 3137110 Negative_regulation ARC EPHB2 24045785 3137111 Negative_regulation ARC EPHB2 24045785 3137211 Negative_regulation ARC TNF 22277195 1660834 Negative_regulation ARF6 MAP2K6 19247477 2406576 Negative_regulation ARG1 LBP 23517687 294301 Negative_regulation ARG1 TNF 23577028 1674547 Negative_regulation ARHGAP4 EPHB2 11425867 1271710 Negative_regulation ARHGEF15 EPHB2 23476809 2003070 Negative_regulation ARHGEF2 EPHB2 22593214 1803203 Negative_regulation ARHGEF2 F2R 20855497 1560265 Negative_regulation ARHGEF2 MAP2K6 22593214 1803209 Negative_regulation ARSA ACE 23976861 731500 Negative_regulation ARSA C12orf39 24137166 969819 Negative_regulation ARSA NAA10 22837307 723986 Negative_regulation ARSA NAA10 22837307 723987 Negative_regulation ARSA NAA11 22837307 724002 Negative_regulation ARSA NAA11 22837307 724003 Negative_regulation ARSA NAA15 22837307 724006 Negative_regulation ARSA NAA15 22837307 724007 Negative_regulation ARSA NAA16 22837307 724000 Negative_regulation ARSA NAA16 22837307 724001 Negative_regulation ARSA NAA20 22837307 723984 Negative_regulation ARSA NAA20 22837307 723985 Negative_regulation ARSA NAA25 22837307 723994 Negative_regulation ARSA NAA25 22837307 723995 Negative_regulation ARSA NAA30 22837307 723988 Negative_regulation ARSA NAA30 22837307 723989 Negative_regulation ARSA NAA35 22837307 723992 Negative_regulation ARSA NAA35 22837307 723993 Negative_regulation ARSA NAA38 22837307 723990 Negative_regulation ARSA NAA38 22837307 723991 Negative_regulation ARSA NAA40 22837307 723996 Negative_regulation ARSA NAA40 22837307 723997 Negative_regulation ARSA NAA50 22837307 724004 Negative_regulation ARSA NAA50 22837307 724005 Negative_regulation ARSA NAA60 22837307 723998 Negative_regulation ARSA NAA60 22837307 723999 Negative_regulation ARSA NOS3 25045211 1760204 Negative_regulation ARSA PAK1 24184502 154216 Negative_regulation ARSA PKN1 24184502 154217 Negative_regulation ARSA PTPN6 23390550 2750897 Negative_regulation ARSD KCNMB4 21837366 2009159 Negative_regulation ARSG FGFR3 24887294 1682687 Negative_regulation ATF2 EPHB2 20562914 2132677 Negative_regulation ATF3 EPHB2 20828393 481702 Negative_regulation ATF3 EPHB2 22870894 802990 Negative_regulation ATF3 EPHB2 25136830 2998969 Negative_regulation ATF3 MAP2K6 22751695 723533 Negative_regulation ATF4 EGLN3 21297970 2498928 Negative_regulation ATF4 EGLN3 24809345 2358877 Negative_regulation ATF4 TLR7 22454627 832542 Negative_regulation ATF4 TLR7 23750267 2801374 Negative_regulation ATF5 CREB3L2 20495567 1961059 Negative_regulation ATF6 PGC 24167585 2872245 Negative_regulation ATP2A2 CAPN8 21931829 2555010 Negative_regulation ATP5O CLU 23986700 858673 Negative_regulation ATP5O CTGF 23451286 2758552 Negative_regulation ATP5O EDN2 12437787 656273 Negative_regulation ATP5O GPR115 15799708 2258116 Negative_regulation ATP5O GPR132 15799708 2258105 Negative_regulation ATP5O GPR87 15799708 2258185 Negative_regulation ATP5O IL1B 16571116 1624877 Negative_regulation ATP5O JAG1 15028114 312876 Negative_regulation ATP5O TNF 18922887 84782 Negative_regulation ATP5O TNFSF10 23284789 2730983 Negative_regulation ATP5O UCA1 24993775 2171801 Negative_regulation ATP6AP2 ZBTB16 21541337 2516986 Negative_regulation ATP6V0D2 DCSTAMP 25352342 1887227 Negative_regulation AVP TNF 19440308 2416702 Negative_regulation AXIN2 APC 14551908 2255120 Negative_regulation AXIN2 APC 24086117 2298879 Negative_regulation AXIN2 APC 24162018 1938335 Negative_regulation AXIN2 BMP1 23831735 1023810 Negative_regulation AXIN2 BMP10 23831735 1023818 Negative_regulation AXIN2 BMP15 23831735 1023811 Negative_regulation AXIN2 BMP2 23831735 1023812 Negative_regulation AXIN2 BMP3 23831735 1023813 Negative_regulation AXIN2 BMP4 23831735 1023814 Negative_regulation AXIN2 BMP5 23831735 1023815 Negative_regulation AXIN2 BMP6 23831735 1023816 Negative_regulation AXIN2 BMP7 23831735 1023817 Negative_regulation AXIN2 DAB2 24474204 3081483 Negative_regulation AXIN2 DKK1 17984306 1547655 Negative_regulation AXIN2 DVL1 24065916 973385 Negative_regulation AXIN2 DVL1 25358879 665197 Negative_regulation AXIN2 DVL1 25632305 1021698 Negative_regulation AXIN2 DVL2 24065916 973386 Negative_regulation AXIN2 DVL2 25358879 665198 Negative_regulation AXIN2 DVL2 25632305 1021699 Negative_regulation AXIN2 DVL3 24065916 973387 Negative_regulation AXIN2 DVL3 25358879 665199 Negative_regulation AXIN2 DVL3 25632305 1021700 Negative_regulation AXIN2 FZD8 20087418 2437386 Negative_regulation AXIN2 HDAC2 23110995 3091538 Negative_regulation AXIN2 JUN 25505480 971909 Negative_regulation AXIN2 LATS2 23977200 2839189 Negative_regulation AXIN2 LRP6 21887268 2548973 Negative_regulation AXIN2 MYLIP 24474204 3081425 Negative_regulation AXIN2 MYLIP 24474204 3081493 Negative_regulation AXIN2 NOTCH1 21998560 2294827 Negative_regulation AXIN2 NOTCH2 21998560 2294828 Negative_regulation AXIN2 NOTCH3 21998560 2294829 Negative_regulation AXIN2 NOTCH4 21998560 2294830 Negative_regulation AXIN2 NPY4R 23016862 692466 Negative_regulation AXIN2 OSR1 24931004 1681317 Negative_regulation AXIN2 PKN1 24114839 1208485 Negative_regulation AXIN2 PKN2 24114839 1208486 Negative_regulation AXIN2 PLK1 23155463 2717652 Negative_regulation AXIN2 RPGR 20087418 2437385 Negative_regulation AXIN2 TBX22 21666721 2140192 Negative_regulation AXIN2 TCF12 22567304 86278 Negative_regulation AXIN2 TCF15 22567304 86279 Negative_regulation AXIN2 TCF19 22567304 86280 Negative_regulation AXIN2 TCF20 22567304 86281 Negative_regulation AXIN2 TCF21 22567304 86282 Negative_regulation AXIN2 TCF23 22567304 86286 Negative_regulation AXIN2 TCF24 22567304 86288 Negative_regulation AXIN2 TCF25 22567304 86287 Negative_regulation AXIN2 TCF3 22567304 86283 Negative_regulation AXIN2 TCF4 22567304 86284 Negative_regulation AXIN2 TCF7 22567304 86285 Negative_regulation AXIN2 TCF7L1 11524435 1274049 Negative_regulation AXIN2 TCF7L2 22540008 2623113 Negative_regulation AXIN2 TCF7L2 23966864 2348549 Negative_regulation AXIN2 TCF7L2 23966864 2348573 Negative_regulation AXIN2 TNKS 24975604 692805 Negative_regulation AXIN2 WNT1 23982808 1142040 Negative_regulation AXIN2 WNT1 24594309 522589 Negative_regulation AXIN2 WNT11 24594309 522590 Negative_regulation AXIN2 WNT16 24594309 522595 Negative_regulation AXIN2 WNT2 24594309 522591 Negative_regulation AXIN2 WNT3 24594309 522592 Negative_regulation AXIN2 WNT3A 24594309 522631 Negative_regulation AXIN2 WNT3A 24658359 2937736 Negative_regulation AXIN2 WNT4 24594309 522593 Negative_regulation AXIN2 WNT5A 24260410 2884085 Negative_regulation AXIN2 WNT6 24594309 522594 Negative_regulation AXIN2 WNT7A 22179044 1928047 Negative_regulation B2M TLR7 20379390 1214435 Negative_regulation BAAT PGC 22087241 2570696 Negative_regulation BAAT TNF 22297440 806715 Negative_regulation BACE1 PGC 24177050 31718 Negative_regulation BACE1 SORL1 16930455 1890642 Negative_regulation BACE1 SORL1 22621900 1803314 Negative_regulation BACE1 SORL1 22621900 1803315 Negative_regulation BACE1 TNF 22047170 1660186 Negative_regulation BACE2 HKDC1 23903356 728340 Negative_regulation BAMBI CTGF 21673687 436932 Negative_regulation BAMBI SCIN 21068720 1918078 Negative_regulation BAX ABCA4 25516716 1063629 Negative_regulation BAX CLU 21042904 3204946 Negative_regulation BAX EPHB2 19895680 1006871 Negative_regulation BAX EPHB2 20648037 1488759 Negative_regulation BAX EPHB2 21998736 2562281 Negative_regulation BAX FAS 11870542 420570 Negative_regulation BAX FAS 18523653 2390329 Negative_regulation BAX KRT38 12499352 1290327 Negative_regulation BAX KRT38 12499352 1290333 Negative_regulation BAX MAP2K6 21411864 2175655 Negative_regulation BAX MAP2K6 23085539 2181404 Negative_regulation BAX OSR1 24931004 1681318 Negative_regulation BCL10 CAPN8 23823868 2283237 Negative_regulation BCL10 CTGF 24637722 2934831 Negative_regulation BCL10 EPHB2 21048967 2480264 Negative_regulation BCL10 EPHB2 22396737 2608352 Negative_regulation BCL10 TNF 11696595 1521635 Negative_regulation BCL10 TNF 22396737 2608351 Negative_regulation BCL10 TNFSF10 20182517 984130 Negative_regulation BCL2 CAPN8 23274414 16664 Negative_regulation BCL2 CAPN8 23823868 2283251 Negative_regulation BCL2 CLU 25411798 1134560 Negative_regulation BCL2 CTGF 24637722 2934832 Negative_regulation BCL2 DAPK1 20145727 1065973 Negative_regulation BCL2 DAPK1 24710481 618718 Negative_regulation BCL2 EPHB2 23363601 1811551 Negative_regulation BCL2 EPHB2 23363601 1811555 Negative_regulation BCL2 EPHB2 24319338 1916505 Negative_regulation BCL2 EPHB2 25013376 1063069 Negative_regulation BCL2 FAS 22087285 2571239 Negative_regulation BCL2 FAS 22175008 1669858 Negative_regulation BCL2 FAS 23019424 636976 Negative_regulation BCL2 FAS 23202971 1098940 Negative_regulation BCL2 LGALS7B 21289092 1786211 Negative_regulation BCL2 RCAN1 25377251 1884311 Negative_regulation BCL2 RNASE1 23819055 3081250 Negative_regulation BCL2 RNASE7 23819055 3081258 Negative_regulation BCL2 STK39 11875716 420679 Negative_regulation BCL2 TLR7 PMC2756345 495797 Negative_regulation BCL2 TNF 11696595 1521637 Negative_regulation BCL2 TNF 14613529 3095433 Negative_regulation BCL2 TNF 17570844 233036 Negative_regulation BCL2 TNF 23429295 560427 Negative_regulation BCL2 TNF 24255667 843873 Negative_regulation BCL2 TNFSF10 20182517 984131 Negative_regulation BCL2 TNFSF10 22949823 1097870 Negative_regulation BCL2 TNFSF10 24113173 567641 Negative_regulation BCL2 TP63 24396276 679769 Negative_regulation BCL2A1 TNF 11696595 1521639 Negative_regulation BCL2L10 TNF 22514694 2619772 Negative_regulation BCL2L11 EPHB2 24651368 2936460 Negative_regulation BCL3 CAPN8 23823868 2283265 Negative_regulation BCL3 CTGF 24637722 2934833 Negative_regulation BCL3 TNF 11696595 1521641 Negative_regulation BCL3 TNFSF10 20182517 984132 Negative_regulation BCL5 CAPN8 23823868 2283195 Negative_regulation BCL5 CTGF 24637722 2934828 Negative_regulation BCL5 TNF 11696595 1521629 Negative_regulation BCL5 TNFSF10 20182517 984127 Negative_regulation BCL6 BPI 21911423 1565322 Negative_regulation BCL6 CAPN8 23823868 2283209 Negative_regulation BCL6 CTGF 24637722 2934829 Negative_regulation BCL6 EPHB2 23708665 2152376 Negative_regulation BCL6 FAS 12860928 1527832 Negative_regulation BCL6 TNF 11696595 1521631 Negative_regulation BCL6 TNFSF10 20182517 984128 Negative_regulation BCL9 CAPN8 23823868 2283223 Negative_regulation BCL9 CTGF 24637722 2934830 Negative_regulation BCL9 TNF 11696595 1521633 Negative_regulation BCL9 TNFSF10 20182517 984129 Negative_regulation BCR CD22 11994425 1523386 Negative_regulation BCR CD22 16630358 105900 Negative_regulation BCR CD22 19103880 1553161 Negative_regulation BCR CD22 22566885 899233 Negative_regulation BCR CD22 22566885 899234 Negative_regulation BCR CD22 22566885 899479 Negative_regulation BCR PECAM1 23185356 2719960 Negative_regulation BCRP1 MAP2K6 23320839 482832 Negative_regulation BCRP1 TNF 25540622 955073 Negative_regulation BCRP2 MAP2K6 23320839 482804 Negative_regulation BCRP2 TNF 25540622 955061 Negative_regulation BCRP3 MAP2K6 23320839 482811 Negative_regulation BCRP3 TNF 25540622 955064 Negative_regulation BCRP4 MAP2K6 23320839 482818 Negative_regulation BCRP4 TNF 25540622 955067 Negative_regulation BCRP5 MAP2K6 23320839 482825 Negative_regulation BCRP5 TNF 25540622 955070 Negative_regulation BCRP6 MAP2K6 23320839 482839 Negative_regulation BCRP6 TNF 25540622 955076 Negative_regulation BCRP7 MAP2K6 23320839 482846 Negative_regulation BCRP7 TNF 25540622 955079 Negative_regulation BCRP8 MAP2K6 23320839 482853 Negative_regulation BCRP8 TNF 25540622 955082 Negative_regulation BCRP9 MAP2K6 23320839 482860 Negative_regulation BCRP9 TNF 25540622 955085 Negative_regulation BDNF EPHB2 21562076 719194 Negative_regulation BDNF EPHB2 21562076 719195 Negative_regulation BDNF EPHB2 23700454 2796230 Negative_regulation BDNF MAP2K6 19390590 2415292 Negative_regulation BDNF PLAT 20162032 927762 Negative_regulation BDNF PLAT 24894914 1843113 Negative_regulation BDNF PLAT 25184365 3004818 Negative_regulation BDNF PLAT 25184365 3004821 Negative_regulation BDNF TNF 25184950 1129351 Negative_regulation BECN1 CAPN8 22496897 2617807 Negative_regulation BECN1 DAPK1 24710481 618717 Negative_regulation BGLAP FOXO1 25187705 1138328 Negative_regulation BGLAP TNF 18163903 1848455 Negative_regulation BGLAP TNF 24116278 204281 Negative_regulation BHLHE41 TP63 21263025 1385065 Negative_regulation BIRC2 TNFSF10 18606850 1353484 Negative_regulation BIRC3 TNF 19421137 2125105 Negative_regulation BLNK TP63 19876398 2430063 Negative_regulation BMF EPHB2 20861305 1782891 Negative_regulation BMF MAP2K6 22258404 554005 Negative_regulation BMP1 CTGF 20706631 2458241 Negative_regulation BMP1 EFNB1 24662724 1941119 Negative_regulation BMP1 EPHB2 21203442 2320604 Negative_regulation BMP1 EPHB2 22547091 603131 Negative_regulation BMP1 EPHB2 23591895 1936248 Negative_regulation BMP1 EPHB2 24586814 2927116 Negative_regulation BMP10 CTGF 20706631 2458249 Negative_regulation BMP10 EPHB2 21203442 2320612 Negative_regulation BMP10 EPHB2 22547091 603315 Negative_regulation BMP10 EPHB2 23591895 1936256 Negative_regulation BMP15 CTGF 20706631 2458242 Negative_regulation BMP15 EPHB2 21203442 2320605 Negative_regulation BMP15 EPHB2 22547091 603154 Negative_regulation BMP15 EPHB2 23591895 1936249 Negative_regulation BMP2 AXIN2 21220513 1384937 Negative_regulation BMP2 CHRDL1 18587495 1908150 Negative_regulation BMP2 CTGF 20706631 2458243 Negative_regulation BMP2 EPHB2 15691373 524141 Negative_regulation BMP2 EPHB2 21203442 2320606 Negative_regulation BMP2 EPHB2 22547091 603177 Negative_regulation BMP2 EPHB2 23591895 1936250 Negative_regulation BMP2 MAP2K6 22870983 288845 Negative_regulation BMP2 MAP2K6 22870983 288943 Negative_regulation BMP2 MSX1 23382810 2746288 Negative_regulation BMP2 WIF1 23560082 2776374 Negative_regulation BMP2 WIF1 23560082 2776649 Negative_regulation BMP2 WIF1 23560082 2776722 Negative_regulation BMP3 CTGF 20706631 2458244 Negative_regulation BMP3 EPHB2 21203442 2320607 Negative_regulation BMP3 EPHB2 22547091 603200 Negative_regulation BMP3 EPHB2 23591895 1936251 Negative_regulation BMP4 CTGF 20706631 2458245 Negative_regulation BMP4 EPHB2 21203442 2320608 Negative_regulation BMP4 EPHB2 22547091 603223 Negative_regulation BMP4 EPHB2 23591895 1936252 Negative_regulation BMP4 MSX1 23382810 2746296 Negative_regulation BMP5 CTGF 20706631 2458246 Negative_regulation BMP5 EPHB2 21203442 2320609 Negative_regulation BMP5 EPHB2 22547091 603246 Negative_regulation BMP5 EPHB2 23591895 1936253 Negative_regulation BMP6 CTGF 20706631 2458247 Negative_regulation BMP6 EPHB2 21203442 2320610 Negative_regulation BMP6 EPHB2 22547091 603269 Negative_regulation BMP6 EPHB2 23591895 1936254 Negative_regulation BMP7 CTGF 19152120 1478385 Negative_regulation BMP7 CTGF 20706631 2458248 Negative_regulation BMP7 EPHB2 21203442 2320611 Negative_regulation BMP7 EPHB2 22547091 603292 Negative_regulation BMP7 EPHB2 23591895 1936255 Negative_regulation BNIP3 TGM2 22458929 1698213 Negative_regulation BPI TLR8 23626859 2785151 Negative_regulation BPNT1 TCN1 22983389 16064 Negative_regulation BRAF CAPN8 23056924 139811 Negative_regulation BRAF EPHB2 21505228 2175847 Negative_regulation BRAF EPHB2 23006971 2181192 Negative_regulation BRAF EPHB2 25538140 1905523 Negative_regulation BRAF MAP2K6 17958888 1242751 Negative_regulation BRAF MAP2K6 21505228 2175868 Negative_regulation BRAF MAP2K6 23226069 2249743 Negative_regulation BRAF MAP2K6 23267331 960512 Negative_regulation BRAF MAP2K6 23826126 2810452 Negative_regulation BRAF MAP2K6 24810962 2190452 Negative_regulation BRAF MAP2K6 25344914 2206106 Negative_regulation BRAF MAP2K6 25435907 745944 Negative_regulation BRCA1 CCND1 18645607 1083727 Negative_regulation BRF1 EPHB2 20226026 375379 Negative_regulation BRMS1 TNF 21765477 2141256 Negative_regulation BRMS1L TNF 21765477 2141287 Negative_regulation BTG2 IL1B 24618842 2933375 Negative_regulation BTK EPHB2 24693884 484332 Negative_regulation BTK TNF 16749930 242022 Negative_regulation BTRC MAP2K6 25401222 2207190 Negative_regulation C22orf29 MAP2K6 24263101 569175 Negative_regulation C3 CFI 22259222 1913745 Negative_regulation C3 CFI 23112567 1915161 Negative_regulation C3 CFI 24369445 1755967 Negative_regulation C3 CFI 559720 1584522 Negative_regulation C4B SERPINA5 20308361 1557839 Negative_regulation C5 SCIN 17893203 1547200 Negative_regulation C5 TNF 2165128 1564030 Negative_regulation C5AR1 TLR7 21630250 808309 Negative_regulation C5AR1 TLR7 21630250 808330 Negative_regulation C5AR2 TLR7 21630250 808283 Negative_regulation CA1 ARSA 24708599 394929 Negative_regulation CA1 CA12 19668427 649330 Negative_regulation CA1 CA12 24959067 649835 Negative_regulation CA1 CA12 24966666 649848 Negative_regulation CA1 CA12 25061272 649861 Negative_regulation CA12 ACO1 22075242 2231443 Negative_regulation CA12 ADH4 944701 1465938 Negative_regulation CA12 ADH5 944701 1465939 Negative_regulation CA12 ADH6 944701 1465940 Negative_regulation CA12 ADH7 944701 1465941 Negative_regulation CA12 ALB 19116015 1767935 Negative_regulation CA12 ALB 23443105 1102541 Negative_regulation CA12 ALB 944701 1465942 Negative_regulation CA12 BID 21605352 3204366 Negative_regulation CA12 BID 21605352 3204379 Negative_regulation CA12 CA1 24300191 2247555 Negative_regulation CA12 CA1 24966670 2234881 Negative_regulation CA12 CA1 25210425 649884 Negative_regulation CA12 CFB 21040564 3099616 Negative_regulation CA12 GDF6 24618041 132041 Negative_regulation CA12 LTF 22075242 2231444 Negative_regulation CA12 MMP3 21201390 2862 Negative_regulation CA12 MMP3 22942690 1096942 Negative_regulation CA12 MT-CO2 3339089 1426407 Negative_regulation CA12 NPPB 9626761 3230221 Negative_regulation CA12 PGA3 23650502 2788790 Negative_regulation CA12 PGA4 23650502 2788791 Negative_regulation CA12 PGA5 23650502 2788792 Negative_regulation CA12 SERPINA4 PMC3909575 43 Negative_regulation CA12 TNFSF11 21955617 124077 Negative_regulation CA12 TPM1 23630428 731448 Negative_regulation CA12 TPM1 23650467 1488651 Negative_regulation CA12 TPM2 23630428 731449 Negative_regulation CA12 TPM2 23650467 1488652 Negative_regulation CA12 TPM3 23630428 731450 Negative_regulation CA12 TPM3 23650467 1488653 Negative_regulation CA12 TPM4 23630428 731451 Negative_regulation CA12 TPM4 23650467 1488654 Negative_regulation CA2 CA12 23300615 2734088 Negative_regulation CA2 CA12 23382857 2746623 Negative_regulation CA2 CAPN8 23734212 2799618 Negative_regulation CA2 CAPN8 24971566 2984700 Negative_regulation CA2 CD22 11956299 1523311 Negative_regulation CA2 CD22 11994425 1523382 Negative_regulation CA2 CD22 11994425 1523387 Negative_regulation CA2 CD22 11994426 1523390 Negative_regulation CA2 EDN2 12437787 656270 Negative_regulation CA2 EDN2 24470488 1611243 Negative_regulation CA2 F2R 8383691 1447821 Negative_regulation CA2 FAS 21477291 527151 Negative_regulation CA2 FOLR1 22558110 2624505 Negative_regulation CA2 GJB2 24465148 842088 Negative_regulation CA2 GPR115 15799708 2258023 Negative_regulation CA2 GPR132 15799708 2258012 Negative_regulation CA2 GPR87 15799708 2258092 Negative_regulation CA2 ITGB2 1346139 1297618 Negative_regulation CA2 MAP2K6 22248814 2177346 Negative_regulation CA2 MUC16 25197168 1761969 Negative_regulation CA2 MYH16 22912631 903764 Negative_regulation CA2 MYH3 22912631 903771 Negative_regulation CA2 PECAM1 23185356 2719983 Negative_regulation CA2 PTGER2 23638853 451462 Negative_regulation CA2 PTGER2 23638853 451463 Negative_regulation CA2 PTGER2 23638853 451478 Negative_regulation CA2 RASA3 9874690 1612994 Negative_regulation CA2 RGS2 20352235 142242 Negative_regulation CA2 RGS2 24470488 1611237 Negative_regulation CA2 RGS2 25197168 1762006 Negative_regulation CA2 TNF 20227109 523191 Negative_regulation CA9 EGLN3 25420773 1947402 Negative_regulation CALB1 CAPN8 24963283 842264 Negative_regulation CALCR TFPI2 22761571 3057404 Negative_regulation CALM3 CABP4 6086671 1429626 Negative_regulation CAMP MMP28 22336948 1630648 Negative_regulation CAMP MMP7 22336948 1630663 Negative_regulation CAPN8 ACTL6A 24811485 2190772 Negative_regulation CAPN8 ADCY1 23056924 140088 Negative_regulation CAPN8 ADCY10 23056924 140087 Negative_regulation CAPN8 ADCY2 23056924 140089 Negative_regulation CAPN8 ADCY3 23056924 140090 Negative_regulation CAPN8 ADCY4 23056924 140091 Negative_regulation CAPN8 ADCY5 23056924 140092 Negative_regulation CAPN8 ADCY6 23056924 140093 Negative_regulation CAPN8 ADCY7 23056924 140094 Negative_regulation CAPN8 ADCY8 23056924 140095 Negative_regulation CAPN8 ADCY9 23056924 140096 Negative_regulation CAPN8 AK2 8449989 1448910 Negative_regulation CAPN8 APOB 18624772 1478917 Negative_regulation CAPN8 ARID1A 24811485 2190771 Negative_regulation CAPN8 ASIC1 24023878 2843942 Negative_regulation CAPN8 ASIP 23593480 2781478 Negative_regulation CAPN8 BCL2 23593137 2779180 Negative_regulation CAPN8 BRAF 23056924 140083 Negative_regulation CAPN8 CA2 18624772 1478916 Negative_regulation CAPN8 CA2 21152086 2486142 Negative_regulation CAPN8 CA2 22190742 1799178 Negative_regulation CAPN8 CA3 18706097 291357 Negative_regulation CAPN8 CALB1 24963283 842276 Negative_regulation CAPN8 CALB1 24963283 842436 Negative_regulation CAPN8 CALB1 24963283 842437 Negative_regulation CAPN8 CAPN1 17880706 320795 Negative_regulation CAPN8 CAPN1 25110686 196197 Negative_regulation CAPN8 CAPN2 17880706 320796 Negative_regulation CAPN8 CAPN2 25110686 196198 Negative_regulation CAPN8 CAPNS1 25110686 196199 Negative_regulation CAPN8 CAST 17083274 3039377 Negative_regulation CAPN8 CAST 18706097 291385 Negative_regulation CAPN8 CAST 18706097 291427 Negative_regulation CAPN8 CAST 20233404 659453 Negative_regulation CAPN8 CAST 20379353 680162 Negative_regulation CAPN8 CAST 21156051 3111793 Negative_regulation CAPN8 CAST 21156051 3111821 Negative_regulation CAPN8 CAST 21670566 3079197 Negative_regulation CAPN8 CAST 21765948 2536626 Negative_regulation CAPN8 CAST 22046434 2567828 Negative_regulation CAPN8 CAST 22096592 2571824 Negative_regulation CAPN8 CAST 22542715 514374 Negative_regulation CAPN8 CAST 23374507 1728263 Negative_regulation CAPN8 CAST 23425388 275235 Negative_regulation CAPN8 CAST 23425388 275588 Negative_regulation CAPN8 CAST 23425388 275814 Negative_regulation CAPN8 CAST 23698771 1107116 Negative_regulation CAPN8 CAST 23781337 2009704 Negative_regulation CAPN8 CAST 24232452 1121525 Negative_regulation CAPN8 CAST 25575026 3037336 Negative_regulation CAPN8 CAST 9566966 1467135 Negative_regulation CAPN8 CAST 9566966 1467215 Negative_regulation CAPN8 CAST 9566966 1467216 Negative_regulation CAPN8 CAST 9566966 1467393 Negative_regulation CAPN8 CAST PMC2364211 450010 Negative_regulation CAPN8 CD3EAP 22470472 2614260 Negative_regulation CAPN8 CTSB 18299403 1549996 Negative_regulation CAPN8 CTSB 9566966 1467362 Negative_regulation CAPN8 CXCL10 10402474 1248134 Negative_regulation CAPN8 CXCL10 10402474 1248135 Negative_regulation CAPN8 CXCL9 10402474 1248567 Negative_regulation CAPN8 CYCS 21886605 928073 Negative_regulation CAPN8 CYCS 22056617 13617 Negative_regulation CAPN8 ECI1 21423701 2508249 Negative_regulation CAPN8 EPO 24344874 1667502 Negative_regulation CAPN8 FLNA 20937704 1560731 Negative_regulation CAPN8 IL8 PMC2173748 1474987 Negative_regulation CAPN8 KHSRP 18978948 2399917 Negative_regulation CAPN8 LGALS3 21368866 550645 Negative_regulation CAPN8 LGALS3 21368866 550646 Negative_regulation CAPN8 LGALS3 21368866 550666 Negative_regulation CAPN8 LGALS3 21368866 550723 Negative_regulation CAPN8 LOX 25309925 201316 Negative_regulation CAPN8 MBTPS1 22407449 87247 Negative_regulation CAPN8 MRE11A 23056924 140099 Negative_regulation CAPN8 MYLIP 23272113 2729599 Negative_regulation CAPN8 NA 22931549 2233471 Negative_regulation CAPN8 NFATC2 23039869 1895563 Negative_regulation CAPN8 NGF 19183810 2405151 Negative_regulation CAPN8 PARP1 23056924 140097 Negative_regulation CAPN8 PDGFB 24454980 2228063 Negative_regulation CAPN8 PF4 10402474 1248568 Negative_regulation CAPN8 PIK3CA PMC2173748 1474988 Negative_regulation CAPN8 PIK3R1 PMC2173748 1474989 Negative_regulation CAPN8 PPP3CA 23039869 1895564 Negative_regulation CAPN8 PPP3R1 23039869 1895565 Negative_regulation CAPN8 PRKACB 10402474 1248351 Negative_regulation CAPN8 PRKACB 23056924 140100 Negative_regulation CAPN8 PRKACG 10402474 1248352 Negative_regulation CAPN8 PRKACG 23056924 140101 Negative_regulation CAPN8 PRKAR1A 10402474 1248353 Negative_regulation CAPN8 PRKAR1A 23056924 140102 Negative_regulation CAPN8 PRKAR1B 10402474 1248354 Negative_regulation CAPN8 PRKAR1B 23056924 140103 Negative_regulation CAPN8 PRKAR2A 10402474 1248355 Negative_regulation CAPN8 PRKAR2A 23056924 140104 Negative_regulation CAPN8 PRKAR2B 10402474 1248356 Negative_regulation CAPN8 PRKAR2B 23056924 140105 Negative_regulation CAPN8 PRPH 22252275 1230108 Negative_regulation CAPN8 PRX 21850160 1912892 Negative_regulation CAPN8 RAD50 23056924 140106 Negative_regulation CAPN8 RB1 23717136 1614255 Negative_regulation CAPN8 RBMS1 23922702 2826249 Negative_regulation CAPN8 SALL1 24394804 1940166 Negative_regulation CAPN8 SALL1 24394804 1940275 Negative_regulation CAPN8 SMARCA4 24811485 2190764 Negative_regulation CAPN8 SMARCB1 24811485 2190765 Negative_regulation CAPN8 SMARCC1 24811485 2190766 Negative_regulation CAPN8 SMARCC2 24811485 2190767 Negative_regulation CAPN8 SMARCD1 24811485 2190768 Negative_regulation CAPN8 SMARCD2 24811485 2190769 Negative_regulation CAPN8 SMARCE1 24811485 2190770 Negative_regulation CAPN8 STAT3 22937084 2682931 Negative_regulation CAPN8 TAT 23951212 2833783 Negative_regulation CAPN8 TERF2 23056924 140084 Negative_regulation CAPN8 TERF2IP 23056924 140086 Negative_regulation CAPN8 XRCC5 23056924 140085 Negative_regulation CAPN8 XRCC6 23056924 140098 Negative_regulation CASP1 EPHB2 15266324 424570 Negative_regulation CASP1 EPHB2 21722370 260392 Negative_regulation CASP1 FAS 10727463 1514835 Negative_regulation CASP1 FAS 19487421 1554892 Negative_regulation CASP1 FAS 22084408 1566120 Negative_regulation CASP1 FAS 25114508 743185 Negative_regulation CASP1 FAS 9730899 1603604 Negative_regulation CASP1 FAS 9730899 1603605 Negative_regulation CASP1 IL1B 23970884 908636 Negative_regulation CASP1 KRT38 12668660 1291711 Negative_regulation CASP1 MAP2K6 15266324 424576 Negative_regulation CASP1 MUC16 24690311 272558 Negative_regulation CASP1 RAB31 19460165 252992 Negative_regulation CASP1 SMN2 19445707 282782 Negative_regulation CASP1 TNF 16115325 1036170 Negative_regulation CASP1 TNF 24066693 269775 Negative_regulation CASP1 TNFSF10 22174792 2581980 Negative_regulation CASP1 TNFSF10 24745479 474912 Negative_regulation CASP10 EPHB2 15266324 424578 Negative_regulation CASP10 EPHB2 21722370 260393 Negative_regulation CASP10 FAS 19487421 1554893 Negative_regulation CASP10 FAS 22084408 1566122 Negative_regulation CASP10 FAS 9730899 1603606 Negative_regulation CASP10 FAS 9730899 1603607 Negative_regulation CASP10 KRT38 12668660 1291714 Negative_regulation CASP10 MAP2K6 15266324 424584 Negative_regulation CASP10 MUC16 24690311 272560 Negative_regulation CASP10 RAB31 19460165 253019 Negative_regulation CASP10 SMN2 19445707 282792 Negative_regulation CASP10 TNF 16115325 1036171 Negative_regulation CASP10 TNF 24066693 269776 Negative_regulation CASP10 TNFSF10 22174792 2581982 Negative_regulation CASP10 TNFSF10 23533482 817808 Negative_regulation CASP10 TNFSF10 24745479 474914 Negative_regulation CASP12 EPHB2 15266324 424658 Negative_regulation CASP12 EPHB2 21722370 260403 Negative_regulation CASP12 FAS 19487421 1554903 Negative_regulation CASP12 FAS 22084408 1566142 Negative_regulation CASP12 FAS 9730899 1603626 Negative_regulation CASP12 FAS 9730899 1603627 Negative_regulation CASP12 KRT38 12668660 1291744 Negative_regulation CASP12 MAP2K6 15266324 424664 Negative_regulation CASP12 MUC16 24690311 272581 Negative_regulation CASP12 RAB31 19460165 253289 Negative_regulation CASP12 SMN2 19445707 282892 Negative_regulation CASP12 TNF 16115325 1036181 Negative_regulation CASP12 TNF 24066693 269787 Negative_regulation CASP12 TNFSF10 22174792 2582002 Negative_regulation CASP12 TNFSF10 24745479 474934 Negative_regulation CASP14 EPHB2 15266324 424586 Negative_regulation CASP14 EPHB2 21722370 260394 Negative_regulation CASP14 FAS 19487421 1554894 Negative_regulation CASP14 FAS 22084408 1566124 Negative_regulation CASP14 FAS 9730899 1603608 Negative_regulation CASP14 FAS 9730899 1603609 Negative_regulation CASP14 KRT38 12668660 1291717 Negative_regulation CASP14 MAP2K6 15266324 424592 Negative_regulation CASP14 MUC16 24690311 272562 Negative_regulation CASP14 RAB31 19460165 253046 Negative_regulation CASP14 SMN2 19445707 282802 Negative_regulation CASP14 TNF 16115325 1036172 Negative_regulation CASP14 TNF 24066693 269777 Negative_regulation CASP14 TNFSF10 22174792 2581984 Negative_regulation CASP14 TNFSF10 24745479 474916 Negative_regulation CASP16 EPHB2 15266324 424666 Negative_regulation CASP16 EPHB2 21722370 260404 Negative_regulation CASP16 FAS 19487421 1554904 Negative_regulation CASP16 FAS 22084408 1566144 Negative_regulation CASP16 FAS 9730899 1603638 Negative_regulation CASP16 FAS 9730899 1603639 Negative_regulation CASP16 KRT38 12668660 1291747 Negative_regulation CASP16 MAP2K6 15266324 424672 Negative_regulation CASP16 MUC16 24690311 272583 Negative_regulation CASP16 RAB31 19460165 253316 Negative_regulation CASP16 SMN2 19445707 282902 Negative_regulation CASP16 TNF 16115325 1036182 Negative_regulation CASP16 TNF 24066693 269788 Negative_regulation CASP16 TNFSF10 22174792 2582004 Negative_regulation CASP16 TNFSF10 24745479 474936 Negative_regulation CASP2 EPHB2 15266324 424594 Negative_regulation CASP2 EPHB2 21722370 260395 Negative_regulation CASP2 FAS 19487421 1554895 Negative_regulation CASP2 FAS 22084408 1566126 Negative_regulation CASP2 FAS 9730899 1603610 Negative_regulation CASP2 FAS 9730899 1603611 Negative_regulation CASP2 KRT38 12668660 1291720 Negative_regulation CASP2 MAP2K6 15266324 424600 Negative_regulation CASP2 MUC16 24690311 272564 Negative_regulation CASP2 RAB31 19460165 253073 Negative_regulation CASP2 SMN2 19445707 282812 Negative_regulation CASP2 TNF 16115325 1036173 Negative_regulation CASP2 TNF 24066693 269778 Negative_regulation CASP2 TNFSF10 22174792 2581986 Negative_regulation CASP2 TNFSF10 24745479 474918 Negative_regulation CASP3 ANGPT1 21113176 12117 Negative_regulation CASP3 ANGPT1 22454630 832606 Negative_regulation CASP3 ANGPT1 24308939 1158517 Negative_regulation CASP3 ANGPT1 24308939 1158702 Negative_regulation CASP3 ANGPT1 24308939 1158915 Negative_regulation CASP3 CAPN8 23425388 275332 Negative_regulation CASP3 CCND1 21304978 2501935 Negative_regulation CASP3 CCND1 23690679 742658 Negative_regulation CASP3 CLU 24717093 157221 Negative_regulation CASP3 EPHB2 15266324 424602 Negative_regulation CASP3 EPHB2 21722370 260396 Negative_regulation CASP3 EPHB2 21936896 1659746 Negative_regulation CASP3 EPHB2 24586814 2927112 Negative_regulation CASP3 EPHB2 24787014 574890 Negative_regulation CASP3 FAS 10601363 1513773 Negative_regulation CASP3 FAS 10727463 1514836 Negative_regulation CASP3 FAS 17162359 630479 Negative_regulation CASP3 FAS 19487421 1554896 Negative_regulation CASP3 FAS 20212524 1903518 Negative_regulation CASP3 FAS 22084408 1566128 Negative_regulation CASP3 FAS 9730899 1603612 Negative_regulation CASP3 FAS 9730899 1603613 Negative_regulation CASP3 FOXO1 21179458 2488041 Negative_regulation CASP3 GLP1R 24843641 1494459 Negative_regulation CASP3 IL1B 25055984 411320 Negative_regulation CASP3 IL1B 25055984 411321 Negative_regulation CASP3 ITGAL 23508943 906585 Negative_regulation CASP3 KRT38 12668660 1291723 Negative_regulation CASP3 KRT38 23166623 2718187 Negative_regulation CASP3 LAMB3 22673183 471570 Negative_regulation CASP3 LGALS7B 24515895 492442 Negative_regulation CASP3 MAOA 21236334 857689 Negative_regulation CASP3 MAP2K6 15266324 424608 Negative_regulation CASP3 MAP2K6 19701232 8052 Negative_regulation CASP3 MAP2K6 19834495 546431 Negative_regulation CASP3 MAP2K6 21798094 3160320 Negative_regulation CASP3 MAP2K6 24886705 1668149 Negative_regulation CASP3 MAP2K6 24939055 1508111 Negative_regulation CASP3 MMP28 12756268 1527188 Negative_regulation CASP3 MMP7 12756268 1527203 Negative_regulation CASP3 MMP7 20139113 513627 Negative_regulation CASP3 MUC16 24690311 272566 Negative_regulation CASP3 OSR1 24931004 1681262 Negative_regulation CASP3 PLAT 21576385 1563920 Negative_regulation CASP3 RAB31 19460165 253100 Negative_regulation CASP3 SMN2 19445707 282822 Negative_regulation CASP3 SPHK1 10545499 1251509 Negative_regulation CASP3 SPHK1 10545499 1251553 Negative_regulation CASP3 SPHK1 10545499 1251557 Negative_regulation CASP3 TNF 16115325 1036174 Negative_regulation CASP3 TNF 19641635 1909328 Negative_regulation CASP3 TNF 21324111 121480 Negative_regulation CASP3 TNF 21324111 121492 Negative_regulation CASP3 TNF 21740583 627018 Negative_regulation CASP3 TNF 21949832 2556774 Negative_regulation CASP3 TNF 24066693 269779 Negative_regulation CASP3 TNF 24283517 130120 Negative_regulation CASP3 TNF 25552899 743680 Negative_regulation CASP3 TNF 9034139 1600015 Negative_regulation CASP3 TNFSF10 22174792 2581988 Negative_regulation CASP3 TNFSF10 22723988 2655522 Negative_regulation CASP3 TNFSF10 24745479 474920 Negative_regulation CASP3 ZFP57 24722354 2951259 Negative_regulation CASP3 ZFP57 24722354 2951295 Negative_regulation CASP4 EPHB2 15266324 424610 Negative_regulation CASP4 EPHB2 21722370 260397 Negative_regulation CASP4 FAS 19487421 1554897 Negative_regulation CASP4 FAS 22084408 1566130 Negative_regulation CASP4 FAS 9730899 1603614 Negative_regulation CASP4 FAS 9730899 1603615 Negative_regulation CASP4 KRT38 12668660 1291726 Negative_regulation CASP4 MAP2K6 15266324 424616 Negative_regulation CASP4 MUC16 24690311 272568 Negative_regulation CASP4 RAB31 19460165 253127 Negative_regulation CASP4 SMN2 19445707 282832 Negative_regulation CASP4 TNF 16115325 1036175 Negative_regulation CASP4 TNF 24066693 269780 Negative_regulation CASP4 TNFSF10 22174792 2581990 Negative_regulation CASP4 TNFSF10 24745479 474922 Negative_regulation CASP5 EPHB2 15266324 424618 Negative_regulation CASP5 EPHB2 21722370 260398 Negative_regulation CASP5 FAS 19487421 1554898 Negative_regulation CASP5 FAS 22084408 1566132 Negative_regulation CASP5 FAS 9730899 1603616 Negative_regulation CASP5 FAS 9730899 1603617 Negative_regulation CASP5 KRT38 12668660 1291729 Negative_regulation CASP5 MAP2K6 15266324 424624 Negative_regulation CASP5 MUC16 24690311 272570 Negative_regulation CASP5 RAB31 19460165 253154 Negative_regulation CASP5 SMN2 19445707 282842 Negative_regulation CASP5 TNF 16115325 1036176 Negative_regulation CASP5 TNF 24066693 269781 Negative_regulation CASP5 TNFSF10 22174792 2581992 Negative_regulation CASP5 TNFSF10 24745479 474924 Negative_regulation CASP6 EPHB2 15266324 424626 Negative_regulation CASP6 EPHB2 21722370 260399 Negative_regulation CASP6 FAS 19487421 1554899 Negative_regulation CASP6 FAS 22084408 1566134 Negative_regulation CASP6 FAS 9730899 1603618 Negative_regulation CASP6 FAS 9730899 1603619 Negative_regulation CASP6 KRT38 12668660 1291732 Negative_regulation CASP6 MAP2K6 15266324 424632 Negative_regulation CASP6 MUC16 24690311 272572 Negative_regulation CASP6 RAB31 19460165 253181 Negative_regulation CASP6 SMN2 19445707 282852 Negative_regulation CASP6 TNF 16115325 1036177 Negative_regulation CASP6 TNF 24066693 269782 Negative_regulation CASP6 TNFSF10 22174792 2581994 Negative_regulation CASP6 TNFSF10 24745479 474926 Negative_regulation CASP7 ANGPT1 24308939 1158518 Negative_regulation CASP7 ANGPT1 24308939 1158703 Negative_regulation CASP7 ANGPT1 24308939 1158916 Negative_regulation CASP7 CCND1 21304978 2501937 Negative_regulation CASP7 EPHB2 15266324 424634 Negative_regulation CASP7 EPHB2 21722370 260400 Negative_regulation CASP7 FAS 19487421 1554900 Negative_regulation CASP7 FAS 22084408 1566136 Negative_regulation CASP7 FAS 9730899 1603620 Negative_regulation CASP7 FAS 9730899 1603621 Negative_regulation CASP7 KRT38 12668660 1291735 Negative_regulation CASP7 MAP2K6 15266324 424640 Negative_regulation CASP7 MUC16 24690311 272574 Negative_regulation CASP7 RAB31 19460165 253208 Negative_regulation CASP7 SMN2 19445707 282862 Negative_regulation CASP7 TNF 16115325 1036178 Negative_regulation CASP7 TNF 24066693 269783 Negative_regulation CASP7 TNFSF10 22174792 2581996 Negative_regulation CASP7 TNFSF10 24745479 474928 Negative_regulation CASP8 EPHB2 15266324 424642 Negative_regulation CASP8 EPHB2 21722370 260401 Negative_regulation CASP8 FAS 10601363 1513774 Negative_regulation CASP8 FAS 11208865 1518750 Negative_regulation CASP8 FAS 11818026 380679 Negative_regulation CASP8 FAS 19487421 1554901 Negative_regulation CASP8 FAS 21625644 2525255 Negative_regulation CASP8 FAS 21738161 1961546 Negative_regulation CASP8 FAS 21760870 2220403 Negative_regulation CASP8 FAS 22084408 1566138 Negative_regulation CASP8 FAS 9730899 1603622 Negative_regulation CASP8 FAS 9730899 1603623 Negative_regulation CASP8 KRT38 12668660 1291738 Negative_regulation CASP8 MAP2K6 15266324 424648 Negative_regulation CASP8 MAP2K6 15266324 424809 Negative_regulation CASP8 MUC16 24690311 272523 Negative_regulation CASP8 MUC16 24690311 272524 Negative_regulation CASP8 MUC16 24690311 272525 Negative_regulation CASP8 MUC16 24690311 272576 Negative_regulation CASP8 MUC16 24690311 272577 Negative_regulation CASP8 MUC16 24690311 272601 Negative_regulation CASP8 RAB31 19460165 253235 Negative_regulation CASP8 SMN2 19445707 282872 Negative_regulation CASP8 TLR7 23386613 1206384 Negative_regulation CASP8 TNF 11696595 1521649 Negative_regulation CASP8 TNF 15907209 248755 Negative_regulation CASP8 TNF 16115325 1036179 Negative_regulation CASP8 TNF 18638380 1722736 Negative_regulation CASP8 TNF 19641635 1909329 Negative_regulation CASP8 TNF 24066693 269784 Negative_regulation CASP8 TNF 24066693 269785 Negative_regulation CASP8 TNFSF10 21092294 1860272 Negative_regulation CASP8 TNFSF10 22174792 2581998 Negative_regulation CASP8 TNFSF10 23348591 559339 Negative_regulation CASP8 TNFSF10 23533482 817809 Negative_regulation CASP8 TNFSF10 24113173 567637 Negative_regulation CASP8 TNFSF10 24473171 1730543 Negative_regulation CASP8 TNFSF10 24745479 474930 Negative_regulation CASP9 EPHB2 15266324 424650 Negative_regulation CASP9 EPHB2 18339080 1727053 Negative_regulation CASP9 EPHB2 21219631 258373 Negative_regulation CASP9 EPHB2 21722370 260402 Negative_regulation CASP9 EPHB2 23657295 3135711 Negative_regulation CASP9 EPHB2 24376709 2901894 Negative_regulation CASP9 FAS 19487421 1554902 Negative_regulation CASP9 FAS 22084408 1566140 Negative_regulation CASP9 FAS 9730899 1603624 Negative_regulation CASP9 FAS 9730899 1603625 Negative_regulation CASP9 FOXO1 23610600 2115281 Negative_regulation CASP9 KRT38 12668660 1291741 Negative_regulation CASP9 MAP2K6 15266324 424656 Negative_regulation CASP9 MAP2K6 21637382 1686166 Negative_regulation CASP9 MMP28 20089176 283938 Negative_regulation CASP9 MMP28 25009698 206317 Negative_regulation CASP9 MMP7 20089176 283953 Negative_regulation CASP9 MMP7 25009698 206332 Negative_regulation CASP9 MUC16 24690311 272579 Negative_regulation CASP9 RAB31 19460165 253262 Negative_regulation CASP9 SMN2 19445707 282882 Negative_regulation CASP9 TNF 16115325 1036180 Negative_regulation CASP9 TNF 24066693 269786 Negative_regulation CASP9 TNFSF10 22174792 2582000 Negative_regulation CASP9 TNFSF10 24745479 474932 Negative_regulation CAT ALOX5 25642165 873027 Negative_regulation CAT FOXO1 22427991 2610956 Negative_regulation CAT FOXO1 23950968 2833043 Negative_regulation CAT FOXO1 23950968 2833058 Negative_regulation CAT FOXO1 24265619 962802 Negative_regulation CAT ID1 8045940 1444361 Negative_regulation CAT TNF 18475533 1744270 Negative_regulation CAT ZFP57 23418595 2754796 Negative_regulation CAV1 CTGF 22684333 541545 Negative_regulation CAV1 EPHB2 25109503 3114686 Negative_regulation CAV1 MIP 23234294 1665462 Negative_regulation CAV1 MMP28 22842734 15755 Negative_regulation CAV1 MMP7 22842734 15770 Negative_regulation CAV1 S100B 20827421 513028 Negative_regulation CAV1 TMEM100 22857383 3084807 Negative_regulation CAV1 TMEM156 22857383 3084825 Negative_regulation CAV1 TMEM211 22857383 3084905 Negative_regulation CAV1 TMEM213 22857383 3084842 Negative_regulation CBFA2T2 EPHB2 24058693 2848577 Negative_regulation CBFA2T2 PECAM1 20723025 1692092 Negative_regulation CBL FAS 23349502 725967 Negative_regulation CBR1 EPHB2 19476641 1897201 Negative_regulation CCL17 CCL19 21483789 2512196 Negative_regulation CCL17 S100A12 23638054 2787443 Negative_regulation CCL19 CCL17 21483789 2512197 Negative_regulation CCL2 ANO1 22973054 1807578 Negative_regulation CCL2 CCL17 23971044 183233 Negative_regulation CCL2 CHI3L1 24399973 963261 Negative_regulation CCL2 CLU 25029271 2990010 Negative_regulation CCL2 EFNB1 24098442 2856373 Negative_regulation CCL2 EPHB2 21789185 2538023 Negative_regulation CCL2 EPHB2 24789665 1886414 Negative_regulation CCL2 EPHB2 24826069 1917004 Negative_regulation CCL2 F2R 20697377 1717664 Negative_regulation CCL2 F2R 22992722 988754 Negative_regulation CCL2 F2R 8163952 1594361 Negative_regulation CCL2 MAP2K6 23198981 1665304 Negative_regulation CCL2 PTGER2 23936109 2829432 Negative_regulation CCL2 RGS2 21494556 2513023 Negative_regulation CCL2 RGS2 21494556 2513024 Negative_regulation CCL2 S100B 24084731 1113174 Negative_regulation CCL2 SMN2 22669976 1203598 Negative_regulation CCL2 TNF 18410682 110455 Negative_regulation CCL2 TNF 18472920 1743140 Negative_regulation CCL2 TNF 18472920 1743141 Negative_regulation CCL2 TNF 18472920 1743142 Negative_regulation CCL2 TNF 19116667 2404022 Negative_regulation CCL2 TNF 21310030 354379 Negative_regulation CCL2 TNF 21752263 123226 Negative_regulation CCL2 TNF 22479654 2371257 Negative_regulation CCL2 TNF 23285282 2733422 Negative_regulation CCL2 TNF 23285282 2733426 Negative_regulation CCL2 TNF 23390582 3134151 Negative_regulation CCL2 TNF 23663236 1666715 Negative_regulation CCL2 TNF 24348712 824563 Negative_regulation CCL20 TNF 23824685 2809243 Negative_regulation CCL22 CCL17 24534492 810324 Negative_regulation CCL3 ARSA 20228931 1037743 Negative_regulation CCL3 CCL17 23971044 183234 Negative_regulation CCL3 MUC16 21331365 632314 Negative_regulation CCL4 TNF 23390582 3134153 Negative_regulation CCL5 TNF 22396727 2608307 Negative_regulation CCL5 TNF 23717673 2798735 Negative_regulation CCL7 EFNB1 24098442 2856374 Negative_regulation CCL7 SMN2 22669976 1203601 Negative_regulation CCNA1 IFI27 20504359 1676876 Negative_regulation CCNA2 CDKN1C 16207381 298602 Negative_regulation CCNA2 TNF 24722330 2951164 Negative_regulation CCNB1 CCND1 23573134 818420 Negative_regulation CCNB1 EPHB2 24489919 2916732 Negative_regulation CCNB1 IFI27 20975996 2478734 Negative_regulation CCNB1 IFI27 22719783 814673 Negative_regulation CCNB1 MAP2K6 21170361 2320495 Negative_regulation CCNB2 IFI27 20975996 2478735 Negative_regulation CCNB3 IFI27 20975996 2478737 Negative_regulation CCNC MAP2K6 21242991 1900777 Negative_regulation CCND1 AIS1 22277572 469723 Negative_regulation CCND1 AIS2 22277572 469724 Negative_regulation CCND1 AIS3 22277572 469725 Negative_regulation CCND1 AK3 22253692 2587598 Negative_regulation CCND1 AKT1 16942622 279256 Negative_regulation CCND1 AKT1 20113529 1853254 Negative_regulation CCND1 AKT1 21559086 2518029 Negative_regulation CCND1 AKT1 22269172 313472 Negative_regulation CCND1 AKT1 22799881 265281 Negative_regulation CCND1 AKT1 23301080 2738097 Negative_regulation CCND1 AKT1 24040362 2846977 Negative_regulation CCND1 AKT1 24236150 2878738 Negative_regulation CCND1 AKT1 24330780 1870583 Negative_regulation CCND1 AKT1 24577313 1124423 Negative_regulation CCND1 AKT1 24690900 2947227 Negative_regulation CCND1 AKT1 24955027 680099 Negative_regulation CCND1 AKT1 25486524 2160772 Negative_regulation CCND1 AKT2 16942622 279257 Negative_regulation CCND1 AKT2 20113529 1853255 Negative_regulation CCND1 AKT2 21559086 2518030 Negative_regulation CCND1 AKT2 22269172 313473 Negative_regulation CCND1 AKT2 22799881 265282 Negative_regulation CCND1 AKT2 23301080 2738098 Negative_regulation CCND1 AKT2 24040362 2846978 Negative_regulation CCND1 AKT2 24236150 2878739 Negative_regulation CCND1 AKT2 24330780 1870584 Negative_regulation CCND1 AKT2 24577313 1124424 Negative_regulation CCND1 AKT2 24690900 2947228 Negative_regulation CCND1 AKT2 24955027 680100 Negative_regulation CCND1 AKT2 25486524 2160773 Negative_regulation CCND1 AKT3 16942622 279258 Negative_regulation CCND1 AKT3 20113529 1853256 Negative_regulation CCND1 AKT3 21559086 2518031 Negative_regulation CCND1 AKT3 22269172 313474 Negative_regulation CCND1 AKT3 22799881 265283 Negative_regulation CCND1 AKT3 23301080 2738099 Negative_regulation CCND1 AKT3 24040362 2846979 Negative_regulation CCND1 AKT3 24236150 2878740 Negative_regulation CCND1 AKT3 24330780 1870585 Negative_regulation CCND1 AKT3 24577313 1124425 Negative_regulation CCND1 AKT3 24690900 2947229 Negative_regulation CCND1 AKT3 24955027 680101 Negative_regulation CCND1 AKT3 25486524 2160774 Negative_regulation CCND1 AMACR 25473890 2207474 Negative_regulation CCND1 APC 20084116 2312682 Negative_regulation CCND1 APC 23024650 3075919 Negative_regulation CCND1 API5 20015364 1676603 Negative_regulation CCND1 APLP2 19433865 1165928 Negative_regulation CCND1 APPL1 19433865 1165927 Negative_regulation CCND1 ARHGEF2 19730435 785920 Negative_regulation CCND1 ARSA 19966835 8438 Negative_regulation CCND1 ATF3 16984628 370006 Negative_regulation CCND1 ATF3 16984628 370059 Negative_regulation CCND1 ATF3 16984628 370109 Negative_regulation CCND1 ATF3 24962785 297233 Negative_regulation CCND1 AVP 24572994 1142513 Negative_regulation CCND1 AXIN1 11739413 1277238 Negative_regulation CCND1 AXIN2 11739413 1277239 Negative_regulation CCND1 BANP 19799771 254307 Negative_regulation CCND1 BCL6 24282530 2886156 Negative_regulation CCND1 BHLHE40 23445622 734337 Negative_regulation CCND1 BHLHE41 18362934 430459 Negative_regulation CCND1 BMP2 21604139 1639755 Negative_regulation CCND1 BRD8 22276175 2590339 Negative_regulation CCND1 BTG1 20300194 2443651 Negative_regulation CCND1 BTG2 20300194 2443652 Negative_regulation CCND1 BTG3 20300194 2443653 Negative_regulation CCND1 BTG4 20300194 2443654 Negative_regulation CCND1 C3 6978374 1586742 Negative_regulation CCND1 C9orf3 23864022 1937183 Negative_regulation CCND1 CASP1 20576164 1856594 Negative_regulation CCND1 CASP10 20576164 1856595 Negative_regulation CCND1 CASP12 20576164 1856605 Negative_regulation CCND1 CASP14 20576164 1856596 Negative_regulation CCND1 CASP16 20576164 1856606 Negative_regulation CCND1 CASP2 20576164 1856597 Negative_regulation CCND1 CASP3 20576164 1856598 Negative_regulation CCND1 CASP3 21304978 2501939 Negative_regulation CCND1 CASP3 23690679 742659 Negative_regulation CCND1 CASP3 25051362 2196742 Negative_regulation CCND1 CASP4 20576164 1856599 Negative_regulation CCND1 CASP5 20576164 1856600 Negative_regulation CCND1 CASP6 20576164 1856601 Negative_regulation CCND1 CASP7 20576164 1856602 Negative_regulation CCND1 CASP7 21304978 2501940 Negative_regulation CCND1 CASP8 20576164 1856603 Negative_regulation CCND1 CASP9 20576164 1856604 Negative_regulation CCND1 CAV1 23598719 543263 Negative_regulation CCND1 CCNB1 23573134 818421 Negative_regulation CCND1 CCT 22253692 2587617 Negative_regulation CCND1 CD44 24257075 484101 Negative_regulation CCND1 CD59 24319687 185630 Negative_regulation CCND1 CDC42 22225989 405881 Negative_regulation CCND1 CDC73 19906718 2048293 Negative_regulation CCND1 CDC73 19906718 2048294 Negative_regulation CCND1 CDC73 19906718 2048308 Negative_regulation CCND1 CDC73 19906718 2048341 Negative_regulation CCND1 CDC73 19906718 2048343 Negative_regulation CCND1 CDC73 22043238 1239562 Negative_regulation CCND1 CDC73 25374962 3175603 Negative_regulation CCND1 CDH1 19015320 1361397 Negative_regulation CCND1 CDH11 22139084 2144748 Negative_regulation CCND1 CDH2 20011526 2433345 Negative_regulation CCND1 CDK2 24884804 1874319 Negative_regulation CCND1 CDK4 20398364 1853915 Negative_regulation CCND1 CDK4 23776433 2804247 Negative_regulation CCND1 CDK4 25156567 2198717 Negative_regulation CCND1 CDK6 25120649 2169249 Negative_regulation CCND1 CDKN1A 11309409 1269376 Negative_regulation CCND1 CDKN1A 16457690 459646 Negative_regulation CCND1 CDKN1A 17066513 3231292 Negative_regulation CCND1 CDKN1A 18665245 2214616 Negative_regulation CCND1 CDKN1A 20010939 434126 Negative_regulation CCND1 CDKN1A 20642839 1647223 Negative_regulation CCND1 CDKN1A 21931726 2554274 Negative_regulation CCND1 CDKN1A 22844494 2668372 Negative_regulation CCND1 CDKN1A 22860097 2671561 Negative_regulation CCND1 CDKN1A 22968658 788010 Negative_regulation CCND1 CDKN1A 23181557 292641 Negative_regulation CCND1 CDKN1A 23243436 816500 Negative_regulation CCND1 CDKN1A 23390492 2750680 Negative_regulation CCND1 CDKN1A 23861801 2820213 Negative_regulation CCND1 CDKN1A 24004818 1618316 Negative_regulation CCND1 CDKN1A 24006921 269670 Negative_regulation CCND1 CDKN1A 24324549 2890736 Negative_regulation CCND1 CDKN1A 24628936 539654 Negative_regulation CCND1 CDKN1A 25296971 2204231 Negative_regulation CCND1 CDKN1A 25309914 201075 Negative_regulation CCND1 CDKN1A 25410904 1884367 Negative_regulation CCND1 CDKN1A 25490312 3148099 Negative_regulation CCND1 CDKN1A 9864370 1473423 Negative_regulation CCND1 CDKN1B 12633504 479916 Negative_regulation CCND1 CDKN1B 20010939 434127 Negative_regulation CCND1 CDKN1B 21179458 2488027 Negative_regulation CCND1 CDKN1B 21179458 2488044 Negative_regulation CCND1 CDKN1B 21179458 2488045 Negative_regulation CCND1 CDKN1B 21209944 2492521 Negative_regulation CCND1 CDKN1B 24638095 607022 Negative_regulation CCND1 CDKN2A 10389982 414527 Negative_regulation CCND1 CDKN2A 11560992 1520832 Negative_regulation CCND1 CDKN2A 19777070 648532 Negative_regulation CCND1 CDKN2A 20157525 25453 Negative_regulation CCND1 CDKN2A 21843312 1505479 Negative_regulation CCND1 CDKN2A 22778947 1688852 Negative_regulation CCND1 CDKN2A 22860097 2671562 Negative_regulation CCND1 CDKN2A 22860097 2671565 Negative_regulation CCND1 CDKN2A 23843700 2249825 Negative_regulation CCND1 CDKN2A 24457962 571544 Negative_regulation CCND1 CDKN2B 24628936 539655 Negative_regulation CCND1 CDKN2B 25387678 454250 Negative_regulation CCND1 CDKN2D 25309971 579608 Negative_regulation CCND1 CDKN3 22844461 2668214 Negative_regulation CCND1 CEBPB 23515068 162125 Negative_regulation CCND1 CEND1 24312406 2889203 Negative_regulation CCND1 CEND1 24312406 2889213 Negative_regulation CCND1 CFH 23884889 728111 Negative_regulation CCND1 CHUK 16987412 384047 Negative_regulation CCND1 CIB1 11309409 1269375 Negative_regulation CCND1 CIB1 19115995 1503527 Negative_regulation CCND1 CIB1 20642839 1647221 Negative_regulation CCND1 CIB1 20865053 2475145 Negative_regulation CCND1 CIB1 23549262 1104719 Negative_regulation CCND1 CIB1 24004818 1618315 Negative_regulation CCND1 CRAT 10953010 1262075 Negative_regulation CCND1 CSE 22870237 2672085 Negative_regulation CCND1 CUL1 17407548 1846328 Negative_regulation CCND1 CYLD 19124656 1553490 Negative_regulation CCND1 CYLD 19124656 1553491 Negative_regulation CCND1 CYLD 19124656 1553530 Negative_regulation CCND1 CYLD 22832488 1631059 Negative_regulation CCND1 DAB2 22491013 771641 Negative_regulation CCND1 DACH1 21931791 2554561 Negative_regulation CCND1 DACT2 23349981 2744234 Negative_regulation CCND1 DDX21 25260534 475742 Negative_regulation CCND1 DIO1 24241350 18646 Negative_regulation CCND1 DIO1 24241350 18647 Negative_regulation CCND1 DIO2 24241350 18648 Negative_regulation CCND1 DIO2 24241350 18649 Negative_regulation CCND1 DIO3 24241350 18650 Negative_regulation CCND1 DIO3 24241350 18651 Negative_regulation CCND1 DUSP16 25077541 577813 Negative_regulation CCND1 DYRK1B 24312406 2889214 Negative_regulation CCND1 DYRK1B 24312406 2889260 Negative_regulation CCND1 E2F1 22768064 2659604 Negative_regulation CCND1 EBP 18283314 430028 Negative_regulation CCND1 EBP 19025630 480606 Negative_regulation CCND1 EGFR 19935697 2128205 Negative_regulation CCND1 EGFR 22056988 1987984 Negative_regulation CCND1 EGFR 24499623 1507749 Negative_regulation CCND1 EGR2 14757751 1305481 Negative_regulation CCND1 EGR2 14757751 1305495 Negative_regulation CCND1 EIF2S2 22253692 2587599 Negative_regulation CCND1 EIF4E 18498250 146232 Negative_regulation CCND1 EIF4EBP1 12633504 479917 Negative_regulation CCND1 EIF4EBP1 12633504 479918 Negative_regulation CCND1 EIF4EBP1 21904669 798969 Negative_regulation CCND1 EPHB2 11309409 1269495 Negative_regulation CCND1 EPHB2 16879721 1163598 Negative_regulation CCND1 EPHB2 19015320 1361399 Negative_regulation CCND1 EPHB2 19165201 431729 Negative_regulation CCND1 EPHB2 22470341 951468 Negative_regulation CCND1 EPHB2 24577313 1124422 Negative_regulation CCND1 EPX 24004818 1618325 Negative_regulation CCND1 ERBB3 23951180 2833665 Negative_regulation CCND1 ESR1 23351343 695272 Negative_regulation CCND1 ESR1 PMC3300818 477078 Negative_regulation CCND1 ETS1 23383271 2749836 Negative_regulation CCND1 FAM60A 22865885 1204251 Negative_regulation CCND1 FBN1 23690679 742660 Negative_regulation CCND1 FBXO31 19412162 1983374 Negative_regulation CCND1 FBXO31 19412162 1983382 Negative_regulation CCND1 FBXO31 25115392 2197734 Negative_regulation CCND1 FBXO31 25115392 2197746 Negative_regulation CCND1 FBXO31 25115392 2197747 Negative_regulation CCND1 FBXO4 19767775 2127060 Negative_regulation CCND1 FBXO4 21242966 2137418 Negative_regulation CCND1 FBXW7 17205132 2374352 Negative_regulation CCND1 FBXW8 17205132 2374313 Negative_regulation CCND1 FBXW8 17205132 2374314 Negative_regulation CCND1 FBXW8 17205132 2374315 Negative_regulation CCND1 FHIT 24396396 844001 Negative_regulation CCND1 FHIT 24396396 844002 Negative_regulation CCND1 FHIT 24396396 844003 Negative_regulation CCND1 FHL2 24736599 2953164 Negative_regulation CCND1 FMR1 20386739 2313467 Negative_regulation CCND1 FMR1 23640459 561713 Negative_regulation CCND1 FOXO1 20668652 2457215 Negative_regulation CCND1 FOXO1 20668652 2457255 Negative_regulation CCND1 FOXO1 23872064 145318 Negative_regulation CCND1 FOXO1 24112473 270041 Negative_regulation CCND1 FOXO3 20504360 256059 Negative_regulation CCND1 FOXO3 20668652 2457216 Negative_regulation CCND1 FOXO3 20668652 2457256 Negative_regulation CCND1 FOXO3 23872064 145319 Negative_regulation CCND1 FOXO4 20668652 2457217 Negative_regulation CCND1 FOXO4 20668652 2457257 Negative_regulation CCND1 FOXO4 23872064 145320 Negative_regulation CCND1 FOXO6 20668652 2457214 Negative_regulation CCND1 FOXO6 20668652 2457254 Negative_regulation CCND1 FOXO6 23872064 145317 Negative_regulation CCND1 FUT1 24056538 3137224 Negative_regulation CCND1 GADD45A 24322524 2118351 Negative_regulation CCND1 GAS5 24884417 273064 Negative_regulation CCND1 GDF11 24244313 2879262 Negative_regulation CCND1 GDF15 14757751 1305494 Negative_regulation CCND1 GJA1 24056538 3137225 Negative_regulation CCND1 GJA1 24056538 3137265 Negative_regulation CCND1 GLI1 23311706 391277 Negative_regulation CCND1 GLI1 25386960 3024889 Negative_regulation CCND1 GPRC5A 25621293 2174115 Negative_regulation CCND1 GSTP1 23426146 2163681 Negative_regulation CCND1 HACE1 23864022 1937094 Negative_regulation CCND1 HBP1 24895061 1483504 Negative_regulation CCND1 HDAC1 17407548 1846382 Negative_regulation CCND1 HDAC1 19479035 2417415 Negative_regulation CCND1 HDAC1 22639737 798279 Negative_regulation CCND1 HDAC1 22865885 1204252 Negative_regulation CCND1 HDAC1 23836985 2121366 Negative_regulation CCND1 HDAC1 24040263 2846299 Negative_regulation CCND1 HDAC2 17407548 1846383 Negative_regulation CCND1 HDAC2 22639737 798280 Negative_regulation CCND1 HDAC2 22865885 1204253 Negative_regulation CCND1 HDAC2 23836985 2121367 Negative_regulation CCND1 HES1 20936110 1672633 Negative_regulation CCND1 HES1 23691206 2794759 Negative_regulation CCND1 HEXIM1 23575664 161539 Negative_regulation CCND1 HIPK2 18644116 1503201 Negative_regulation CCND1 HIPK2 18644116 1503206 Negative_regulation CCND1 HLA-DRB1 21179458 2488028 Negative_regulation CCND1 HLA-DRB1 21179458 2488046 Negative_regulation CCND1 HLA-DRB1 21179458 2488047 Negative_regulation CCND1 HLA-DRB1 21179458 2488083 Negative_regulation CCND1 HLA-DRB1 21209944 2492522 Negative_regulation CCND1 HNRNPD 21799732 2538389 Negative_regulation CCND1 HPD 22403544 951090 Negative_regulation CCND1 HPR 20537156 1855704 Negative_regulation CCND1 HPR 21951911 482308 Negative_regulation CCND1 ID1 21955753 260966 Negative_regulation CCND1 IFI27 11309409 1269377 Negative_regulation CCND1 IFI27 19115995 1503528 Negative_regulation CCND1 IFI27 19602254 253747 Negative_regulation CCND1 IFI27 20504360 256060 Negative_regulation CCND1 IFI27 21209944 2492513 Negative_regulation CCND1 IFI27 23549262 1104720 Negative_regulation CCND1 IFI27 24006921 269671 Negative_regulation CCND1 IKBKB 16987412 384048 Negative_regulation CCND1 IKBKG 16987412 384049 Negative_regulation CCND1 IL8 25165728 1623139 Negative_regulation CCND1 ILK 11402061 1271034 Negative_regulation CCND1 ILK 11402061 1271036 Negative_regulation CCND1 ILK 12835312 1293325 Negative_regulation CCND1 ILK 12835312 1293383 Negative_regulation CCND1 ILK 19885839 1486052 Negative_regulation CCND1 INHBA 24628936 539656 Negative_regulation CCND1 IRF1 24119616 510283 Negative_regulation CCND1 ISL1 21829621 2542097 Negative_regulation CCND1 JARID2 18564434 323726 Negative_regulation CCND1 JUN 12631385 457637 Negative_regulation CCND1 JUN 16689993 1242556 Negative_regulation CCND1 JUN 22727408 265083 Negative_regulation CCND1 JUNB 16689993 1242558 Negative_regulation CCND1 KIDINS220 25410904 1884357 Negative_regulation CCND1 KIDINS220 25410904 1884368 Negative_regulation CCND1 KLF4 20514221 672526 Negative_regulation CCND1 KLF4 21687630 2528707 Negative_regulation CCND1 KLF5 24236150 2878757 Negative_regulation CCND1 KLF6 20126619 2439397 Negative_regulation CCND1 KRIT1 20668652 2457253 Negative_regulation CCND1 KRIT1 24291398 857918 Negative_regulation CCND1 LATS2 23977200 2839110 Negative_regulation CCND1 LATS2 23977200 2839181 Negative_regulation CCND1 LATS2 23977200 2839185 Negative_regulation CCND1 LBH 24093956 1869858 Negative_regulation CCND1 LBH 25557837 3149184 Negative_regulation CCND1 LEFTY1 25473455 1144958 Negative_regulation CCND1 LEFTY2 25473455 1144957 Negative_regulation CCND1 LILRB1 24281003 442573 Negative_regulation CCND1 LILRB1 24281003 442585 Negative_regulation CCND1 LILRB1 24570594 2122646 Negative_regulation CCND1 LMO4 19648968 2126229 Negative_regulation CCND1 MACC1 23573286 2778086 Negative_regulation CCND1 MAP2K7 11560992 1520844 Negative_regulation CCND1 MAPK1 11134071 1266031 Negative_regulation CCND1 MAPK1 17407548 1846335 Negative_regulation CCND1 MAPK1 19015320 1361400 Negative_regulation CCND1 MAPK1 19159010 1055261 Negative_regulation CCND1 MAPK1 20113529 1853257 Negative_regulation CCND1 MAPK1 21457229 451349 Negative_regulation CCND1 MAPK1 24766860 1507875 Negative_regulation CCND1 MAPK10 11134071 1266032 Negative_regulation CCND1 MAPK10 19015320 1361401 Negative_regulation CCND1 MAPK10 19159010 1055262 Negative_regulation CCND1 MAPK10 20113529 1853258 Negative_regulation CCND1 MAPK10 24766860 1507876 Negative_regulation CCND1 MAPK11 11134071 1266033 Negative_regulation CCND1 MAPK11 19015320 1361402 Negative_regulation CCND1 MAPK11 19159010 1055263 Negative_regulation CCND1 MAPK11 20113529 1853259 Negative_regulation CCND1 MAPK11 24766860 1507877 Negative_regulation CCND1 MAPK12 11134071 1266034 Negative_regulation CCND1 MAPK12 19015320 1361403 Negative_regulation CCND1 MAPK12 19159010 1055264 Negative_regulation CCND1 MAPK12 20113529 1853260 Negative_regulation CCND1 MAPK12 24766860 1507878 Negative_regulation CCND1 MAPK13 11134071 1266035 Negative_regulation CCND1 MAPK13 19015320 1361404 Negative_regulation CCND1 MAPK13 19159010 1055265 Negative_regulation CCND1 MAPK13 20113529 1853261 Negative_regulation CCND1 MAPK13 24766860 1507879 Negative_regulation CCND1 MAPK14 11134071 1266036 Negative_regulation CCND1 MAPK14 19015320 1361405 Negative_regulation CCND1 MAPK14 19159010 1055266 Negative_regulation CCND1 MAPK14 20113529 1853262 Negative_regulation CCND1 MAPK14 24766860 1507880 Negative_regulation CCND1 MAPK15 11134071 1266030 Negative_regulation CCND1 MAPK15 19015320 1361398 Negative_regulation CCND1 MAPK15 19159010 1055260 Negative_regulation CCND1 MAPK15 20113529 1853253 Negative_regulation CCND1 MAPK15 24766860 1507874 Negative_regulation CCND1 MAPK3 11134071 1266037 Negative_regulation CCND1 MAPK3 19015320 1361406 Negative_regulation CCND1 MAPK3 19159010 1055267 Negative_regulation CCND1 MAPK3 19818165 464753 Negative_regulation CCND1 MAPK3 20113529 1853263 Negative_regulation CCND1 MAPK3 21457229 451350 Negative_regulation CCND1 MAPK3 21887232 2548013 Negative_regulation CCND1 MAPK3 23187001 219781 Negative_regulation CCND1 MAPK3 24766860 1507881 Negative_regulation CCND1 MAPK3 24955027 680102 Negative_regulation CCND1 MAPK4 11134071 1266038 Negative_regulation CCND1 MAPK4 19015320 1361407 Negative_regulation CCND1 MAPK4 19159010 1055268 Negative_regulation CCND1 MAPK4 20113529 1853264 Negative_regulation CCND1 MAPK4 24766860 1507882 Negative_regulation CCND1 MAPK6 11134071 1266039 Negative_regulation CCND1 MAPK6 19015320 1361408 Negative_regulation CCND1 MAPK6 19159010 1055269 Negative_regulation CCND1 MAPK6 20113529 1853265 Negative_regulation CCND1 MAPK6 24766860 1507883 Negative_regulation CCND1 MAPK7 11134071 1266040 Negative_regulation CCND1 MAPK7 19015320 1361409 Negative_regulation CCND1 MAPK7 19159010 1055270 Negative_regulation CCND1 MAPK7 20113529 1853266 Negative_regulation CCND1 MAPK7 24766860 1507884 Negative_regulation CCND1 MAPK8 11134071 1266041 Negative_regulation CCND1 MAPK8 19015320 1361410 Negative_regulation CCND1 MAPK8 19159010 1055271 Negative_regulation CCND1 MAPK8 20113529 1853267 Negative_regulation CCND1 MAPK8 24766860 1507885 Negative_regulation CCND1 MAPK9 11134071 1266042 Negative_regulation CCND1 MAPK9 19015320 1361411 Negative_regulation CCND1 MAPK9 19159010 1055272 Negative_regulation CCND1 MAPK9 20113529 1853268 Negative_regulation CCND1 MAPK9 24766860 1507886 Negative_regulation CCND1 MCTS1 23645982 3188953 Negative_regulation CCND1 MIR145 23710609 483376 Negative_regulation CCND1 MIR296 21461395 1673111 Negative_regulation CCND1 MIR34B 24616890 1078468 Negative_regulation CCND1 MIR520B 22319632 2595646 Negative_regulation CCND1 MIR520B 22319632 2595656 Negative_regulation CCND1 MKNK1 24551240 2923424 Negative_regulation CCND1 MSC 21804822 1693388 Negative_regulation CCND1 MSI1 22428049 2611389 Negative_regulation CCND1 MST1 21423209 2138729 Negative_regulation CCND1 MT2A 23870553 1700164 Negative_regulation CCND1 MT2A 23870553 1700166 Negative_regulation CCND1 MT2A 23870553 1700168 Negative_regulation CCND1 MTA1 21209952 2492590 Negative_regulation CCND1 MTA2 21209952 2492591 Negative_regulation CCND1 MTA3 21209952 2492589 Negative_regulation CCND1 MTOR 20562900 9996 Negative_regulation CCND1 MTOR 20630061 256628 Negative_regulation CCND1 MYC 23776433 2804248 Negative_regulation CCND1 MYLIP 18695042 1354615 Negative_regulation CCND1 MYLIP 18695042 1354639 Negative_regulation CCND1 MYLIP 18695042 1354640 Negative_regulation CCND1 MYLIP 18701644 2035883 Negative_regulation CCND1 MYLIP 18701644 2035894 Negative_regulation CCND1 MYLIP 19881910 672071 Negative_regulation CCND1 MYLIP 19881910 672078 Negative_regulation CCND1 MYLIP 19881910 672081 Negative_regulation CCND1 MYLIP 20948989 2174556 Negative_regulation CCND1 MYLIP 20948989 2174562 Negative_regulation CCND1 MYLIP 21368870 550822 Negative_regulation CCND1 MYLIP 22260523 263255 Negative_regulation CCND1 MYLIP 22260523 263256 Negative_regulation CCND1 MYLIP 22308266 2179656 Negative_regulation CCND1 MYLIP 22319632 2595652 Negative_regulation CCND1 MYLIP 22382486 1639697 Negative_regulation CCND1 MYLIP 22723898 2655051 Negative_regulation CCND1 MYLIP 22911796 2676686 Negative_regulation CCND1 MYLIP 22912826 2679564 Negative_regulation CCND1 MYLIP 23383003 2747582 Negative_regulation CCND1 MYLIP 23383271 2749826 Negative_regulation CCND1 MYLIP 23383271 2749831 Negative_regulation CCND1 MYLIP 23383271 2749835 Negative_regulation CCND1 MYLIP 23383271 2749847 Negative_regulation CCND1 MYLIP 23383271 2749858 Negative_regulation CCND1 MYLIP 23383271 2749860 Negative_regulation CCND1 MYLIP 23383271 2749861 Negative_regulation CCND1 MYLIP 23451060 2757396 Negative_regulation CCND1 MYLIP 23533632 2770824 Negative_regulation CCND1 MYLIP 23558708 3126599 Negative_regulation CCND1 MYLIP 23640459 561715 Negative_regulation CCND1 MYLIP 23967867 1700266 Negative_regulation CCND1 MYLIP 24083596 269844 Negative_regulation CCND1 MYLIP 24098737 2859496 Negative_regulation CCND1 MYLIP 24191129 737426 Negative_regulation CCND1 MYLIP 24191129 737556 Negative_regulation CCND1 MYLIP 24470117 3081317 Negative_regulation CCND1 MYLIP 24505359 2920733 Negative_regulation CCND1 MYLIP 24564330 346932 Negative_regulation CCND1 MYLIP 24728149 2951810 Negative_regulation CCND1 MYLIP 24812632 190367 Negative_regulation CCND1 MYLIP 24936138 1085252 Negative_regulation CCND1 MYLIP 24991193 484737 Negative_regulation CCND1 MYLIP 24991193 484740 Negative_regulation CCND1 MYLIP 24991193 484746 Negative_regulation CCND1 MYLIP 24995320 194190 Negative_regulation CCND1 MYLIP 25379703 3023841 Negative_regulation CCND1 NEFH 20140245 2440156 Negative_regulation CCND1 NEFH 20140245 2440191 Negative_regulation CCND1 NF2 17924978 452635 Negative_regulation CCND1 NFKB1 22616941 336516 Negative_regulation CCND1 NFKB1 23515068 162126 Negative_regulation CCND1 NOTCH1 22570653 1673870 Negative_regulation CCND1 NOX1 20531308 2132517 Negative_regulation CCND1 NPM1 18625744 1551566 Negative_regulation CCND1 NPTX1 23259795 1699218 Negative_regulation CCND1 NR0B1 20421209 2053459 Negative_regulation CCND1 OGT 23029544 2698717 Negative_regulation CCND1 ORAOV1 20105337 1853219 Negative_regulation CCND1 OSR1 24931004 1681263 Negative_regulation CCND1 PAK3 24163148 728810 Negative_regulation CCND1 PAPSS1 17786207 2377981 Negative_regulation CCND1 PCNA 21092078 258050 Negative_regulation CCND1 PDCD4 24157866 568403 Negative_regulation CCND1 PDGFB 10662779 1255823 Negative_regulation CCND1 PDLIM7 24499623 1507667 Negative_regulation CCND1 PER1 23012497 454591 Negative_regulation CCND1 PER2 23012497 454592 Negative_regulation CCND1 PIK3CA 23591839 1105856 Negative_regulation CCND1 PIK3CA 24577313 1124462 Negative_regulation CCND1 PIK3R1 24577313 1124463 Negative_regulation CCND1 PIN1 12631385 457638 Negative_regulation CCND1 PIN1 20801874 1188436 Negative_regulation CCND1 PKN1 25335797 3071244 Negative_regulation CCND1 PLAC1 24304549 270626 Negative_regulation CCND1 PLSCR1 23259795 1699225 Negative_regulation CCND1 PMEL 24386256 2903363 Negative_regulation CCND1 PML 15837800 1319963 Negative_regulation CCND1 PMPCB 21436991 1221734 Negative_regulation CCND1 PMPCB 23974100 544262 Negative_regulation CCND1 PNKD 23542180 218433 Negative_regulation CCND1 POU5F1 23433354 267898 Negative_regulation CCND1 POU5F1 24946789 840739 Negative_regulation CCND1 PPARG 23865481 344243 Negative_regulation CCND1 PPIA 20047682 328077 Negative_regulation CCND1 PRDX2 16503970 1845100 Negative_regulation CCND1 PRDX2 16504004 1845102 Negative_regulation CCND1 PRDX2 16504004 1845103 Negative_regulation CCND1 PRDX2 16504004 1845173 Negative_regulation CCND1 PRDX2 16504004 1845180 Negative_regulation CCND1 PRDX2 20609221 1856731 Negative_regulation CCND1 PRDX2 20609221 1856742 Negative_regulation CCND1 PRDX2 24116279 204282 Negative_regulation CCND1 PRDX2 24130929 204566 Negative_regulation CCND1 PRDX2 24280698 2244887 Negative_regulation CCND1 PRDX2 24280698 2244889 Negative_regulation CCND1 PRDX2 24970821 2194488 Negative_regulation CCND1 PRINS 23344029 1101024 Negative_regulation CCND1 PRKAA1 19046439 1646463 Negative_regulation CCND1 PRKAA1 19046439 1646519 Negative_regulation CCND1 PRKAA1 20824095 2473694 Negative_regulation CCND1 PRKAA1 22194737 832306 Negative_regulation CCND1 PRKAA2 19046439 1646464 Negative_regulation CCND1 PRKAA2 19046439 1646520 Negative_regulation CCND1 PRKAA2 20824095 2473695 Negative_regulation CCND1 PRKAA2 22194737 832307 Negative_regulation CCND1 PRKAB1 19046439 1646465 Negative_regulation CCND1 PRKAB1 19046439 1646521 Negative_regulation CCND1 PRKAB1 20824095 2473696 Negative_regulation CCND1 PRKAB1 22194737 832308 Negative_regulation CCND1 PRKAB2 19046439 1646466 Negative_regulation CCND1 PRKAB2 19046439 1646522 Negative_regulation CCND1 PRKAB2 20824095 2473697 Negative_regulation CCND1 PRKAB2 22194737 832309 Negative_regulation CCND1 PRKAG1 19046439 1646467 Negative_regulation CCND1 PRKAG1 19046439 1646523 Negative_regulation CCND1 PRKAG1 20824095 2473698 Negative_regulation CCND1 PRKAG1 22194737 832310 Negative_regulation CCND1 PRKAG2 19046439 1646468 Negative_regulation CCND1 PRKAG2 19046439 1646524 Negative_regulation CCND1 PRKAG2 20824095 2473699 Negative_regulation CCND1 PRKAG2 22194737 832311 Negative_regulation CCND1 PRL 16677418 459822 Negative_regulation CCND1 PRL 24146212 477569 Negative_regulation CCND1 PSEN1 11266469 1269223 Negative_regulation CCND1 PTEN 11402061 1271032 Negative_regulation CCND1 PTEN 11402061 1271035 Negative_regulation CCND1 PTEN 11402061 1271037 Negative_regulation CCND1 PTEN 19384426 668855 Negative_regulation CCND1 PTEN 19384426 668881 Negative_regulation CCND1 PTEN 19707334 175474 Negative_regulation CCND1 PTEN 24858043 2155162 Negative_regulation CCND1 PTEN 25009983 2987599 Negative_regulation CCND1 PTEN 25202365 2169626 Negative_regulation CCND1 PTGER2 25327961 216528 Negative_regulation CCND1 PTGER2 25327961 216563 Negative_regulation CCND1 PTH 17319972 1645441 Negative_regulation CCND1 RAC1 24523791 1685714 Negative_regulation CCND1 RAD1 21695126 2529449 Negative_regulation CCND1 RAD17 21695126 2529450 Negative_regulation CCND1 RAD18 21695126 2529448 Negative_regulation CCND1 RAD21 21695126 2529451 Negative_regulation CCND1 RAD50 21695126 2529452 Negative_regulation CCND1 RAD51 21695126 2529453 Negative_regulation CCND1 RAD52 21695126 2529454 Negative_regulation CCND1 RANBP9 24312406 2889202 Negative_regulation CCND1 RARRES3 21858038 2545832 Negative_regulation CCND1 RASSF1 17692468 157387 Negative_regulation CCND1 RASSF1 22438769 1243122 Negative_regulation CCND1 RASSF1 22548173 1831166 Negative_regulation CCND1 RASSF1 22701175 1831320 Negative_regulation CCND1 RASSF1 22727408 265084 Negative_regulation CCND1 RB1 23776433 2804249 Negative_regulation CCND1 RB1 25490312 3148100 Negative_regulation CCND1 RB1 8175885 1445646 Negative_regulation CCND1 RB1 8175885 1445673 Negative_regulation CCND1 RB1CC1 22709873 1866091 Negative_regulation CCND1 RBBP4 17407548 1846384 Negative_regulation CCND1 RBBP4 22639737 798281 Negative_regulation CCND1 RBBP4 22865885 1204254 Negative_regulation CCND1 RBBP4 23836985 2121368 Negative_regulation CCND1 RBBP7 17407548 1846385 Negative_regulation CCND1 RBBP7 22639737 798282 Negative_regulation CCND1 RBBP7 22865885 1204255 Negative_regulation CCND1 RBBP7 23836985 2121369 Negative_regulation CCND1 RELA 22541644 3161053 Negative_regulation CCND1 RELA 22616941 336517 Negative_regulation CCND1 RELA 23515068 162127 Negative_regulation CCND1 RHO 16776827 3107312 Negative_regulation CCND1 RHOA 19527220 164040 Negative_regulation CCND1 RHOC 23382905 2746731 Negative_regulation CCND1 RNF146 24454854 2910157 Negative_regulation CCND1 RNMT 24419005 502745 Negative_regulation CCND1 ROCK1 19527220 164038 Negative_regulation CCND1 ROCK2 19527220 164039 Negative_regulation CCND1 RUNX2 21029421 466670 Negative_regulation CCND1 SAP18 22865885 1204248 Negative_regulation CCND1 SAP30 22865885 1204249 Negative_regulation CCND1 SEMA3A 25285016 2123510 Negative_regulation CCND1 SETD2 23300831 2736158 Negative_regulation CCND1 SFN 20642839 1647281 Negative_regulation CCND1 SFN 23927827 269599 Negative_regulation CCND1 SFRP5 25120720 2169593 Negative_regulation CCND1 SH3D19 18283314 430026 Negative_regulation CCND1 SHH 22799764 265250 Negative_regulation CCND1 SIN3A 22865885 1204250 Negative_regulation CCND1 SKP2 16504004 1845121 Negative_regulation CCND1 SKP2 17407548 1846327 Negative_regulation CCND1 SLC12A9 16457690 459645 Negative_regulation CCND1 SLC12A9 20010939 434125 Negative_regulation CCND1 SLC12A9 20642839 1647222 Negative_regulation CCND1 SLC12A9 23861801 2820212 Negative_regulation CCND1 SMAD1 24236150 2878642 Negative_regulation CCND1 SMAD1 24236150 2878741 Negative_regulation CCND1 SMAD2 24236150 2878643 Negative_regulation CCND1 SMAD2 24236150 2878742 Negative_regulation CCND1 SMAD3 19479035 2417365 Negative_regulation CCND1 SMAD3 24236150 2878644 Negative_regulation CCND1 SMAD3 24236150 2878743 Negative_regulation CCND1 SMAD4 24236150 2878645 Negative_regulation CCND1 SMAD4 24236150 2878744 Negative_regulation CCND1 SMAD4 24236150 2878759 Negative_regulation CCND1 SMAD5 24236150 2878646 Negative_regulation CCND1 SMAD5 24236150 2878745 Negative_regulation CCND1 SMAD6 24236150 2878647 Negative_regulation CCND1 SMAD6 24236150 2878746 Negative_regulation CCND1 SMAD7 24236150 2878648 Negative_regulation CCND1 SMAD7 24236150 2878747 Negative_regulation CCND1 SMAD9 24236150 2878649 Negative_regulation CCND1 SMAD9 24236150 2878748 Negative_regulation CCND1 SMARCA4 21102582 436230 Negative_regulation CCND1 SMARCB1 19503603 3044154 Negative_regulation CCND1 SMARCB1 22988546 941269 Negative_regulation CCND1 SNAI1 19124656 1553529 Negative_regulation CCND1 SOAT1 19888451 2430285 Negative_regulation CCND1 SOX2 22912670 2677272 Negative_regulation CCND1 SOX2 24946789 840738 Negative_regulation CCND1 SOX6 19479035 2417414 Negative_regulation CCND1 SOX6 21985497 305925 Negative_regulation CCND1 SOX6 24040263 2846297 Negative_regulation CCND1 SOX6 24040263 2846298 Negative_regulation CCND1 SOX7 23295859 2182076 Negative_regulation CCND1 SOX7 23295859 2182077 Negative_regulation CCND1 SOX7 24816720 2963007 Negative_regulation CCND1 SOX7 24816720 2963009 Negative_regulation CCND1 SOX7 24816720 2963010 Negative_regulation CCND1 SOX7 24816720 2963011 Negative_regulation CCND1 SOX9 17698607 1343169 Negative_regulation CCND1 SPAG11B 25327961 216607 Negative_regulation CCND1 SRC 24137325 2165456 Negative_regulation CCND1 SRC 24743777 504256 Negative_regulation CCND1 STAT1 22423663 1865268 Negative_regulation CCND1 STAT3 19523218 1625345 Negative_regulation CCND1 STAT3 21486470 286590 Negative_regulation CCND1 STAT3 22216901 1698096 Negative_regulation CCND1 STAT3 22216901 1698103 Negative_regulation CCND1 STAT3 22423663 1865269 Negative_regulation CCND1 STAT3 22427843 2610404 Negative_regulation CCND1 STAT3 24069553 1706821 Negative_regulation CCND1 STAT3 24155666 1061957 Negative_regulation CCND1 STAT3 24499623 1507666 Negative_regulation CCND1 STAT3 24499623 1507748 Negative_regulation CCND1 STK11 23861764 2819807 Negative_regulation CCND1 SULF1 24970807 2193960 Negative_regulation CCND1 SUV39H1 19906718 2048292 Negative_regulation CCND1 SUV39H1 19906718 2048310 Negative_regulation CCND1 SUV39H1 19906718 2048340 Negative_regulation CCND1 SUV39H1 23361235 806805 Negative_regulation CCND1 SUV39H1 24564251 346912 Negative_regulation CCND1 SYK 21394647 607602 Negative_regulation CCND1 SYT1 22541644 3161052 Negative_regulation CCND1 SYT1 25412312 579213 Negative_regulation CCND1 SYT1 25412312 579214 Negative_regulation CCND1 TCEAL1 22879971 2673354 Negative_regulation CCND1 TCEAL1 23050783 266520 Negative_regulation CCND1 TCF12 17637831 2377171 Negative_regulation CCND1 TCF12 22570653 1673745 Negative_regulation CCND1 TCF15 17637831 2377172 Negative_regulation CCND1 TCF15 22570653 1673746 Negative_regulation CCND1 TCF19 17637831 2377173 Negative_regulation CCND1 TCF19 22570653 1673747 Negative_regulation CCND1 TCF20 17637831 2377174 Negative_regulation CCND1 TCF20 22570653 1673748 Negative_regulation CCND1 TCF21 17637831 2377175 Negative_regulation CCND1 TCF21 22570653 1673749 Negative_regulation CCND1 TCF23 17637831 2377179 Negative_regulation CCND1 TCF23 22570653 1673760 Negative_regulation CCND1 TCF24 17637831 2377181 Negative_regulation CCND1 TCF24 22570653 1673762 Negative_regulation CCND1 TCF25 17637831 2377180 Negative_regulation CCND1 TCF25 22570653 1673761 Negative_regulation CCND1 TCF3 17637831 2377176 Negative_regulation CCND1 TCF3 22570653 1673750 Negative_regulation CCND1 TCF4 17637831 2377177 Negative_regulation CCND1 TCF4 22570653 1673751 Negative_regulation CCND1 TCF7 17637831 2377178 Negative_regulation CCND1 TCF7 22570653 1673752 Negative_regulation CCND1 TCHP 25502685 3033828 Negative_regulation CCND1 TGFBR2 25473455 1144956 Negative_regulation CCND1 TMED7 20504360 256057 Negative_regulation CCND1 TMED7 20642839 1647224 Negative_regulation CCND1 TMED7 20865053 2475146 Negative_regulation CCND1 TMED7 21179458 2488082 Negative_regulation CCND1 TMED7 21209944 2492502 Negative_regulation CCND1 TMED7 23883349 294556 Negative_regulation CCND1 TMED7 24004818 1618317 Negative_regulation CCND1 TMED7 25202365 2169625 Negative_regulation CCND1 TNC 15714209 425373 Negative_regulation CCND1 TNC 25138052 2198181 Negative_regulation CCND1 TNFSF10 21179458 2488026 Negative_regulation CCND1 TNFSF10 21209944 2492472 Negative_regulation CCND1 TNFSF10 21209944 2492486 Negative_regulation CCND1 TNFSF11 19237598 1364377 Negative_regulation CCND1 TOB1 20513747 1558426 Negative_regulation CCND1 TOB1 21677822 641220 Negative_regulation CCND1 TOB1 22158108 14201 Negative_regulation CCND1 TP53 18665245 2214598 Negative_regulation CCND1 TP53 18665245 2214615 Negative_regulation CCND1 TP53 22860097 2671560 Negative_regulation CCND1 TP53 24962785 297232 Negative_regulation CCND1 TRG 21144036 1647929 Negative_regulation CCND1 TRG 21144036 1647930 Negative_regulation CCND1 TRO 24091475 2184962 Negative_regulation CCND1 TSC22D3 19814803 1852070 Negative_regulation CCND1 TWIST1 23935727 843460 Negative_regulation CCND1 ULK1 21513503 291739 Negative_regulation CCND1 VEGFA 19358707 659156 Negative_regulation CCND1 VEGFA 24069553 1706822 Negative_regulation CCND1 WNK1 22616941 336515 Negative_regulation CCND1 WNK1 25412312 579211 Negative_regulation CCND1 WNT1 22570653 1673753 Negative_regulation CCND1 WNT1 24136230 568122 Negative_regulation CCND1 WNT1 25386960 3024882 Negative_regulation CCND1 WNT11 22570653 1673754 Negative_regulation CCND1 WNT11 25386960 3024883 Negative_regulation CCND1 WNT16 22570653 1673759 Negative_regulation CCND1 WNT16 25386960 3024888 Negative_regulation CCND1 WNT2 22570653 1673755 Negative_regulation CCND1 WNT2 25386960 3024884 Negative_regulation CCND1 WNT3 22570653 1673756 Negative_regulation CCND1 WNT3 25386960 3024885 Negative_regulation CCND1 WNT3A 22491013 771640 Negative_regulation CCND1 WNT3A 24273411 2122484 Negative_regulation CCND1 WNT4 22570653 1673757 Negative_regulation CCND1 WNT4 25386960 3024886 Negative_regulation CCND1 WNT6 22570653 1673758 Negative_regulation CCND1 WNT6 25386960 3024887 Negative_regulation CCND1 XPO1 16503970 1845081 Negative_regulation CCND1 XPO1 16503970 1845092 Negative_regulation CCND1 XPO1 16503970 1845097 Negative_regulation CCND1 XPO1 16504004 1845101 Negative_regulation CCND1 YBX1 23462806 440318 Negative_regulation CCND1 ZNF703 23991038 2840604 Negative_regulation CCND2 FOXO1 25321482 578468 Negative_regulation CCND2 FOXO1 25330112 3017214 Negative_regulation CCND3 IFI27 7629502 1591055 Negative_regulation CCND3 SPHK1 22563011 1033701 Negative_regulation CCNE1 CDKN1C 22211105 1058748 Negative_regulation CCNE1 IFI27 20504359 1676878 Negative_regulation CCNE1 IFI27 20876711 716607 Negative_regulation CCNE1 IFI27 22558078 2624238 Negative_regulation CCNE1 IFI27 23029392 2697101 Negative_regulation CCNE1 IFI27 25371703 656877 Negative_regulation CCNE2 IFI27 25371703 656879 Negative_regulation CCNG1 CCND1 17003776 428230 Negative_regulation CCNG1 EPHB2 21910869 3091302 Negative_regulation CCNG2 TP63 21263025 1385064 Negative_regulation CCNT1 PGC 23173091 976281 Negative_regulation CCNT1 RNASE1 17341462 2026614 Negative_regulation CCR2 FOXO1 22586579 722743 Negative_regulation CCR2 FOXO1 22586579 722765 Negative_regulation CCR2 TLR7 24466057 2912728 Negative_regulation CCR5 TNF 21508508 736860 Negative_regulation CCR7 TLR7 23935491 3063316 Negative_regulation CCR7 TNF 19277197 2407715 Negative_regulation CCR7 TNF 19277197 2407762 Negative_regulation CCR7 TNF 21731495 3052135 Negative_regulation CCT TNF 16403237 3106028 Negative_regulation CD14 APOB 20946675 1723328 Negative_regulation CD14 BPI 22429567 660209 Negative_regulation CD14 CAMP 23840194 908068 Negative_regulation CD14 CCK 25125801 1760487 Negative_regulation CD14 CD9 24040034 2845292 Negative_regulation CD14 CSF2 24083466 356492 Negative_regulation CD14 EPHB2 24083466 356498 Negative_regulation CD14 HNRNPF 22194898 2583318 Negative_regulation CD14 HNRNPH1 22194898 2583319 Negative_regulation CD14 IL4 24083466 356493 Negative_regulation CD14 LEP 23762319 2802990 Negative_regulation CD14 LEP 24192824 1121484 Negative_regulation CD14 LYL1 25035669 3205477 Negative_regulation CD14 MEIS1 17254313 232994 Negative_regulation CD14 PMEL 23259067 1719018 Negative_regulation CD14 PTBP1 22194898 2583320 Negative_regulation CD14 PTBP2 22194898 2583317 Negative_regulation CD14 RPE 23133491 816233 Negative_regulation CD14 SPI1 22879381 2080311 Negative_regulation CD14 TLR2 20011115 3045867 Negative_regulation CD14 TNF 25332099 607541 Negative_regulation CD14 TNFRSF9 23437083 2755515 Negative_regulation CD19 CD22 PMC3991031 2245477 Negative_regulation CD19 TP63 19876398 2430071 Negative_regulation CD2 MMP28 18629305 793255 Negative_regulation CD2 MMP7 18629305 793270 Negative_regulation CD209 CLU 25512691 3216621 Negative_regulation CD209 TLR7 16279841 2368535 Negative_regulation CD22 ENDOU 24344237 1574238 Negative_regulation CD24 NR2F1 23785296 2346926 Negative_regulation CD24 S100A7 23300877 2736919 Negative_regulation CD274 TNF 19451266 1554818 Negative_regulation CD274 TNF 22389764 3130464 Negative_regulation CD28 TLR7 22737174 636487 Negative_regulation CD28 TNF PMC3273158 99554 Negative_regulation CD36 PGC 23964012 781871 Negative_regulation CD36 TLR7 PMC3007784 1702471 Negative_regulation CD36 TNF 16104828 2368420 Negative_regulation CD36 TNF 19925655 327029 Negative_regulation CD3D TNF 23803414 3121917 Negative_regulation CD3E TNF 23803414 3121919 Negative_regulation CD3G TNF 23803414 3121921 Negative_regulation CD4 FAS 24130482 3064388 Negative_regulation CD4 FAS 25045210 1760187 Negative_regulation CD4 FAS 7540652 1590356 Negative_regulation CD4 FAS 9064331 1600257 Negative_regulation CD4 ITGAL 25414732 641076 Negative_regulation CD4 ITGB2 20065994 1041658 Negative_regulation CD4 MUC16 24204874 2874691 Negative_regulation CD4 NT5E 25242869 1762302 Negative_regulation CD4 TLR7 21124820 3050061 Negative_regulation CD40 CHI3L1 7595208 1590811 Negative_regulation CD40 MMP28 20921282 1560493 Negative_regulation CD40 MMP7 20921282 1560509 Negative_regulation CD40 TNF 24222935 1755100 Negative_regulation CD40 TNF 25071777 913377 Negative_regulation CD40LG TNF 24098562 2858174 Negative_regulation CD44 CCND1 24257075 484102 Negative_regulation CD44 FAS 8769429 1455892 Negative_regulation CD44 FAS 8769429 1455893 Negative_regulation CD47 TNFSF10 24303189 2251610 Negative_regulation CD55 FOXO1 23786484 32893 Negative_regulation CD6 TNF 23924897 1817704 Negative_regulation CD69 SELL 22096557 2571715 Negative_regulation CD79A CD22 16630358 105901 Negative_regulation CD79A CD22 22566885 899247 Negative_regulation CD79A CD22 22566885 899248 Negative_regulation CD79A CD22 22566885 899480 Negative_regulation CD79A PECAM1 23185356 2719963 Negative_regulation CD79A PIGR 14768948 629958 Negative_regulation CD79A PIGR 15559365 630325 Negative_regulation CD79A TNF 20016738 2114380 Negative_regulation CD79A TP63 19876398 2430076 Negative_regulation CD79B CD22 16630358 105902 Negative_regulation CD79B CD22 22566885 899261 Negative_regulation CD79B CD22 22566885 899262 Negative_regulation CD79B CD22 22566885 899481 Negative_regulation CD79B PECAM1 23185356 2719964 Negative_regulation CD79B TNF 7931065 1593190 Negative_regulation CD80 ITGAL 24904430 965214 Negative_regulation CD80 ITGB2 22737152 902010 Negative_regulation CD80 TLR7 20379390 1214365 Negative_regulation CD80 TLR7 23691339 1151658 Negative_regulation CD80 TNF 10899908 1516330 Negative_regulation CD83 TLR7 22193989 488272 Negative_regulation CD86 ITGAL 24904430 965217 Negative_regulation CD86 ITGB2 22737152 902011 Negative_regulation CD86 MAP2K6 21054882 2231176 Negative_regulation CD86 TLR7 20379390 1214379 Negative_regulation CD86 TLR7 22193989 488282 Negative_regulation CD86 TLR7 23936008 2828962 Negative_regulation CD86 TNF 10899908 1516331 Negative_regulation CD86 TNF 22566973 900659 Negative_regulation CD86 TNF 23781340 1497108 Negative_regulation CD86 TNF 25071777 913378 Negative_regulation CD8A FAS 7540652 1590357 Negative_regulation CD8A FAS 9064331 1600258 Negative_regulation CD8A GPR132 23094142 1669605 Negative_regulation CD8A NT5E 23125523 1225570 Negative_regulation CD8A NT5E 25242869 1762304 Negative_regulation CD8A SELL 15769185 2257997 Negative_regulation CD8A STK39 25339948 914678 Negative_regulation CD8A TLR7 21124820 3050072 Negative_regulation CD8A TNF 23874808 2822893 Negative_regulation CD8B FAS 9064331 1600259 Negative_regulation CD8B SELL 15769185 2257998 Negative_regulation CD8B TLR7 21124820 3050083 Negative_regulation CD9 MAP2K6 25200404 3145504 Negative_regulation CDC123 MAP2K6 22970192 2687681 Negative_regulation CDC123 RAB31 22848547 2669295 Negative_regulation CDC123 SLC6A2 11960554 368970 Negative_regulation CDC123 SLC6A2 15251038 277815 Negative_regulation CDC16 RAB31 22848547 2669322 Negative_regulation CDC16 SLC6A2 11960554 368971 Negative_regulation CDC16 SLC6A2 15251038 277816 Negative_regulation CDC20 RAB31 22848547 2669349 Negative_regulation CDC20 SLC6A2 11960554 368972 Negative_regulation CDC20 SLC6A2 15251038 277817 Negative_regulation CDC23 RAB31 22848547 2669376 Negative_regulation CDC23 SLC6A2 11960554 368973 Negative_regulation CDC23 SLC6A2 15251038 277818 Negative_regulation CDC26 RAB31 22848547 2669619 Negative_regulation CDC26 SLC6A2 11960554 368982 Negative_regulation CDC26 SLC6A2 15251038 277827 Negative_regulation CDC27 RAB31 22848547 2669403 Negative_regulation CDC27 SLC6A2 11960554 368974 Negative_regulation CDC27 SLC6A2 15251038 277819 Negative_regulation CDC34 RAB31 22848547 2669430 Negative_regulation CDC34 SLC6A2 11960554 368975 Negative_regulation CDC34 SLC6A2 15251038 277820 Negative_regulation CDC37 RAB31 22848547 2669457 Negative_regulation CDC37 SLC6A2 11960554 368976 Negative_regulation CDC37 SLC6A2 15251038 277821 Negative_regulation CDC37 TFPI2 18922470 1876986 Negative_regulation CDC40 RAB31 22848547 2669484 Negative_regulation CDC40 SLC6A2 11960554 368977 Negative_regulation CDC40 SLC6A2 15251038 277822 Negative_regulation CDC42 DAPK1 16476779 1327889 Negative_regulation CDC42 RAB31 22848547 2669511 Negative_regulation CDC42 SLC6A2 11960554 368978 Negative_regulation CDC42 SLC6A2 15251038 277823 Negative_regulation CDC45 RAB31 22848547 2669538 Negative_regulation CDC45 SLC6A2 11960554 368979 Negative_regulation CDC45 SLC6A2 15251038 277824 Negative_regulation CDC6 RAB31 22848547 2669565 Negative_regulation CDC6 SLC6A2 11960554 368980 Negative_regulation CDC6 SLC6A2 15251038 277825 Negative_regulation CDC7 RAB31 22848547 2669592 Negative_regulation CDC7 SLC6A2 11960554 368981 Negative_regulation CDC7 SLC6A2 15251038 277826 Negative_regulation CDC73 F2R PMC2756345 495992 Negative_regulation CDC73 LPCAT1 25415055 177534 Negative_regulation CDC73 RAB31 22848547 2669268 Negative_regulation CDC73 SLC6A2 11960554 368969 Negative_regulation CDC73 SLC6A2 15251038 277814 Negative_regulation CDC73 TNF 18472926 1743188 Negative_regulation CDC73 TNF 3119758 1580173 Negative_regulation CDCA5 NES 25329792 3016293 Negative_regulation CDH1 CEACAM6 25398131 3027591 Negative_regulation CDH1 CHI3L1 21991364 2561588 Negative_regulation CDH1 CLDN10 21619599 3112181 Negative_regulation CDH1 CTGF 20393144 713774 Negative_regulation CDH1 EPHB2 14623871 1301276 Negative_regulation CDH1 EPHB2 14623871 1301443 Negative_regulation CDH1 EPHB2 14623871 1301479 Negative_regulation CDH1 EPHB2 14623871 1301487 Negative_regulation CDH1 EPHB2 25216515 2199646 Negative_regulation CDH1 FOXA1 22391567 2146660 Negative_regulation CDH1 FOXA1 22590586 2642250 Negative_regulation CDH1 FOXA1 22590586 2642260 Negative_regulation CDH1 FOXA1 22590586 2642262 Negative_regulation CDH1 FOXQ1 23383267 2749811 Negative_regulation CDH1 FOXQ1 24312263 2888319 Negative_regulation CDH1 FOXQ1 25356753 2206483 Negative_regulation CDH1 FOXQ1 25356753 2206491 Negative_regulation CDH1 ID1 19951400 1006921 Negative_regulation CDH1 ID1 23320068 2739487 Negative_regulation CDH1 JAG1 17984306 1547479 Negative_regulation CDH1 MAP2K6 16365168 1326380 Negative_regulation CDH1 MAP2K6 23208503 2150290 Negative_regulation CDH1 MMP7 23173031 2719398 Negative_regulation CDH1 MMP7 25081188 840959 Negative_regulation CDH1 NEDD9 20808771 2471836 Negative_regulation CDH1 NEDD9 21829474 2541143 Negative_regulation CDH1 PLAU 22593767 1673875 Negative_regulation CDH1 TMPRSS4 24748857 1021862 Negative_regulation CDH1 TNF 20691079 257048 Negative_regulation CDH1 TNF 22426696 14547 Negative_regulation CDH1 TNF 22426696 14550 Negative_regulation CDH1 TNF 25143751 645513 Negative_regulation CDH1 VSNL1 22479362 2614926 Negative_regulation CDH1 WIF1 20573255 1856507 Negative_regulation CDH1 WIF1 20573255 1856508 Negative_regulation CDH1 WIF1 20573255 1856526 Negative_regulation CDH1 WNT7A 23284647 2730380 Negative_regulation CDH2 MAP2K6 23208503 2150297 Negative_regulation CDH2 MMP7 20139113 513566 Negative_regulation CDH2 WIF1 20573255 1856509 Negative_regulation CDH5 EPHB2 22837859 3086192 Negative_regulation CDH5 EPHB2 23157718 3207781 Negative_regulation CDH5 TNF 20871620 11958 Negative_regulation CDK1 CCND1 20334671 255659 Negative_regulation CDK1 CCND1 21124766 2484039 Negative_regulation CDK1 CCND1 22684298 541487 Negative_regulation CDK1 CCND1 22684298 541523 Negative_regulation CDK1 CCND1 22839099 265487 Negative_regulation CDK1 CCND1 23029062 2694392 Negative_regulation CDK1 CDKN1C 10390005 414561 Negative_regulation CDK1 CDKN1C 10424746 415039 Negative_regulation CDK1 CDKN1C 10698719 789654 Negative_regulation CDK1 CDKN1C 10944603 417391 Negative_regulation CDK1 CDKN1C 17020917 2023097 Negative_regulation CDK1 CDKN1C 17459161 3108261 Negative_regulation CDK1 CDKN1C 17505532 2376080 Negative_regulation CDK1 CDKN1C 20573229 2220857 Negative_regulation CDK1 CDKN1C 20596014 1985509 Negative_regulation CDK1 CDKN1C 21042410 2479579 Negative_regulation CDK1 CDKN1C 21497086 666107 Negative_regulation CDK1 CDKN1C 21504908 738958 Negative_regulation CDK1 CDKN1C 21801602 623865 Negative_regulation CDK1 CDKN1C 22920283 291071 Negative_regulation CDK1 CDKN1C 23231927 3226521 Negative_regulation CDK1 CDKN1C 24039437 2121622 Negative_regulation CDK1 CDKN1C 24389287 2186463 Negative_regulation CDK1 CDKN1C 25408871 608411 Negative_regulation CDK1 DAPK1 25226156 3007649 Negative_regulation CDK1 EPHB2 23609496 1105975 Negative_regulation CDK1 EPHB2 23936173 2829584 Negative_regulation CDK1 EPHB2 24489919 2916733 Negative_regulation CDK1 IFI27 11259087 418368 Negative_regulation CDK1 IFI27 11309409 1269382 Negative_regulation CDK1 IFI27 11309409 1269383 Negative_regulation CDK1 IFI27 14981092 1306351 Negative_regulation CDK1 IFI27 16759351 579665 Negative_regulation CDK1 IFI27 16759363 579742 Negative_regulation CDK1 IFI27 18060053 2381061 Negative_regulation CDK1 IFI27 18551186 3072501 Negative_regulation CDK1 IFI27 19079338 2124125 Negative_regulation CDK1 IFI27 19660140 584128 Negative_regulation CDK1 IFI27 19664228 584165 Negative_regulation CDK1 IFI27 20049729 774409 Negative_regulation CDK1 IFI27 20831799 375738 Negative_regulation CDK1 IFI27 20975996 2478736 Negative_regulation CDK1 IFI27 22087251 2570747 Negative_regulation CDK1 IFI27 22719783 814678 Negative_regulation CDK1 IFI27 22733130 2147440 Negative_regulation CDK1 IFI27 23130001 960182 Negative_regulation CDK1 IFI27 23409140 2753768 Negative_regulation CDK1 IFI27 23801714 727571 Negative_regulation CDK1 IFI27 23896637 1150366 Negative_regulation CDK1 IFI27 24586821 2927167 Negative_regulation CDK1 IFI27 24695788 2948364 Negative_regulation CDK1 IFI27 24955023 680047 Negative_regulation CDK1 IFI27 25141103 1129045 Negative_regulation CDK1 IFI27 25278894 954842 Negative_regulation CDK1 IFI27 25321482 578473 Negative_regulation CDK1 IFI27 25351620 1887132 Negative_regulation CDK1 IFI27 25392689 490154 Negative_regulation CDK1 IFI27 25565868 2123764 Negative_regulation CDK1 IFI27 9155043 446205 Negative_regulation CDK1 IFI27 PMC3871896 1136490 Negative_regulation CDK1 IFI27 PMC4033971 2245930 Negative_regulation CDK1 MAP2K6 23804146 799989 Negative_regulation CDK10 CCND1 20334671 255663 Negative_regulation CDK10 CCND1 21124766 2484043 Negative_regulation CDK10 CCND1 22684298 541489 Negative_regulation CDK10 CCND1 22684298 541525 Negative_regulation CDK10 CCND1 22839099 265491 Negative_regulation CDK10 CCND1 23029062 2694398 Negative_regulation CDK10 CDKN1C 10390005 414563 Negative_regulation CDK10 CDKN1C 10424746 415041 Negative_regulation CDK10 CDKN1C 10698719 789656 Negative_regulation CDK10 CDKN1C 10944603 417393 Negative_regulation CDK10 CDKN1C 17020917 2023099 Negative_regulation CDK10 CDKN1C 17459161 3108265 Negative_regulation CDK10 CDKN1C 17505532 2376082 Negative_regulation CDK10 CDKN1C 20573229 2220859 Negative_regulation CDK10 CDKN1C 20596014 1985511 Negative_regulation CDK10 CDKN1C 21042410 2479581 Negative_regulation CDK10 CDKN1C 21504908 738960 Negative_regulation CDK10 CDKN1C 21801602 623867 Negative_regulation CDK10 CDKN1C 22920283 291073 Negative_regulation CDK10 CDKN1C 23231927 3226523 Negative_regulation CDK10 CDKN1C 24039437 2121628 Negative_regulation CDK10 CDKN1C 24389287 2186465 Negative_regulation CDK10 CDKN1C 25408871 608413 Negative_regulation CDK10 DAPK1 25226156 3007653 Negative_regulation CDK10 EPHB2 23609496 1105977 Negative_regulation CDK10 EPHB2 23936173 2829586 Negative_regulation CDK10 IFI27 11259087 418370 Negative_regulation CDK10 IFI27 11309409 1269394 Negative_regulation CDK10 IFI27 11309409 1269395 Negative_regulation CDK10 IFI27 14981092 1306357 Negative_regulation CDK10 IFI27 18060053 2381063 Negative_regulation CDK10 IFI27 18551186 3072503 Negative_regulation CDK10 IFI27 19079338 2124129 Negative_regulation CDK10 IFI27 19660140 584130 Negative_regulation CDK10 IFI27 19664228 584169 Negative_regulation CDK10 IFI27 20049729 774413 Negative_regulation CDK10 IFI27 20831799 375742 Negative_regulation CDK10 IFI27 22087251 2570751 Negative_regulation CDK10 IFI27 22733130 2147442 Negative_regulation CDK10 IFI27 23801714 727577 Negative_regulation CDK10 IFI27 23896637 1150374 Negative_regulation CDK10 IFI27 24586821 2927171 Negative_regulation CDK10 IFI27 24695788 2948366 Negative_regulation CDK10 IFI27 24955023 680051 Negative_regulation CDK10 IFI27 25141103 1129047 Negative_regulation CDK10 IFI27 25278894 954844 Negative_regulation CDK10 IFI27 25321482 578477 Negative_regulation CDK10 IFI27 25351620 1887136 Negative_regulation CDK10 IFI27 25565868 2123768 Negative_regulation CDK10 IFI27 9155043 446207 Negative_regulation CDK10 IFI27 PMC3871896 1136498 Negative_regulation CDK10 IFI27 PMC4033971 2245932 Negative_regulation CDK10 MAP2K6 23804146 800003 Negative_regulation CDK12 CCND1 20334671 255686 Negative_regulation CDK12 CCND1 21124766 2484065 Negative_regulation CDK12 CCND1 22684298 541503 Negative_regulation CDK12 CCND1 22684298 541536 Negative_regulation CDK12 CCND1 22839099 265513 Negative_regulation CDK12 CCND1 23029062 2694431 Negative_regulation CDK12 CDKN1C 10390005 414574 Negative_regulation CDK12 CDKN1C 10424746 415054 Negative_regulation CDK12 CDKN1C 10698719 789667 Negative_regulation CDK12 CDKN1C 10944603 417404 Negative_regulation CDK12 CDKN1C 17020917 2023110 Negative_regulation CDK12 CDKN1C 17459161 3108287 Negative_regulation CDK12 CDKN1C 17505532 2376093 Negative_regulation CDK12 CDKN1C 20573229 2220870 Negative_regulation CDK12 CDKN1C 20596014 1985522 Negative_regulation CDK12 CDKN1C 21042410 2479593 Negative_regulation CDK12 CDKN1C 21504908 738971 Negative_regulation CDK12 CDKN1C 21801602 623878 Negative_regulation CDK12 CDKN1C 22920283 291084 Negative_regulation CDK12 CDKN1C 23231927 3226534 Negative_regulation CDK12 CDKN1C 24039437 2121661 Negative_regulation CDK12 CDKN1C 24389287 2186476 Negative_regulation CDK12 CDKN1C 25408871 608424 Negative_regulation CDK12 DAPK1 25226156 3007675 Negative_regulation CDK12 EPHB2 23609496 1105988 Negative_regulation CDK12 EPHB2 23936173 2829598 Negative_regulation CDK12 IFI27 11259087 418381 Negative_regulation CDK12 IFI27 11309409 1269460 Negative_regulation CDK12 IFI27 11309409 1269461 Negative_regulation CDK12 IFI27 14981092 1306390 Negative_regulation CDK12 IFI27 18060053 2381074 Negative_regulation CDK12 IFI27 18551186 3072514 Negative_regulation CDK12 IFI27 19079338 2124151 Negative_regulation CDK12 IFI27 19660140 584141 Negative_regulation CDK12 IFI27 19664228 584191 Negative_regulation CDK12 IFI27 20049729 774435 Negative_regulation CDK12 IFI27 20831799 375764 Negative_regulation CDK12 IFI27 22087251 2570773 Negative_regulation CDK12 IFI27 22733130 2147453 Negative_regulation CDK12 IFI27 23801714 727612 Negative_regulation CDK12 IFI27 23896637 1150418 Negative_regulation CDK12 IFI27 24586821 2927193 Negative_regulation CDK12 IFI27 24695788 2948377 Negative_regulation CDK12 IFI27 24955023 680073 Negative_regulation CDK12 IFI27 25141103 1129058 Negative_regulation CDK12 IFI27 25278894 954855 Negative_regulation CDK12 IFI27 25321482 578499 Negative_regulation CDK12 IFI27 25351620 1887158 Negative_regulation CDK12 IFI27 25565868 2123790 Negative_regulation CDK12 IFI27 9155043 446218 Negative_regulation CDK12 IFI27 PMC3871896 1136542 Negative_regulation CDK12 IFI27 PMC4033971 2245943 Negative_regulation CDK12 MAP2K6 23804146 800080 Negative_regulation CDK13 CCND1 20334671 255661 Negative_regulation CDK13 CCND1 21124766 2484041 Negative_regulation CDK13 CCND1 22684298 541488 Negative_regulation CDK13 CCND1 22684298 541524 Negative_regulation CDK13 CCND1 22839099 265489 Negative_regulation CDK13 CCND1 23029062 2694395 Negative_regulation CDK13 CDKN1C 10390005 414562 Negative_regulation CDK13 CDKN1C 10424746 415040 Negative_regulation CDK13 CDKN1C 10698719 789655 Negative_regulation CDK13 CDKN1C 10944603 417392 Negative_regulation CDK13 CDKN1C 17020917 2023098 Negative_regulation CDK13 CDKN1C 17459161 3108263 Negative_regulation CDK13 CDKN1C 17505532 2376081 Negative_regulation CDK13 CDKN1C 20573229 2220858 Negative_regulation CDK13 CDKN1C 20596014 1985510 Negative_regulation CDK13 CDKN1C 21042410 2479580 Negative_regulation CDK13 CDKN1C 21504908 738959 Negative_regulation CDK13 CDKN1C 21801602 623866 Negative_regulation CDK13 CDKN1C 22920283 291072 Negative_regulation CDK13 CDKN1C 23231927 3226522 Negative_regulation CDK13 CDKN1C 24039437 2121625 Negative_regulation CDK13 CDKN1C 24389287 2186464 Negative_regulation CDK13 CDKN1C 25408871 608412 Negative_regulation CDK13 DAPK1 25226156 3007651 Negative_regulation CDK13 EPHB2 23609496 1105976 Negative_regulation CDK13 EPHB2 23936173 2829585 Negative_regulation CDK13 IFI27 11259087 418369 Negative_regulation CDK13 IFI27 11309409 1269388 Negative_regulation CDK13 IFI27 11309409 1269389 Negative_regulation CDK13 IFI27 14981092 1306354 Negative_regulation CDK13 IFI27 18060053 2381062 Negative_regulation CDK13 IFI27 18551186 3072502 Negative_regulation CDK13 IFI27 19079338 2124127 Negative_regulation CDK13 IFI27 19660140 584129 Negative_regulation CDK13 IFI27 19664228 584167 Negative_regulation CDK13 IFI27 20049729 774411 Negative_regulation CDK13 IFI27 20831799 375740 Negative_regulation CDK13 IFI27 22087251 2570749 Negative_regulation CDK13 IFI27 22733130 2147441 Negative_regulation CDK13 IFI27 23801714 727574 Negative_regulation CDK13 IFI27 23896637 1150370 Negative_regulation CDK13 IFI27 24586821 2927169 Negative_regulation CDK13 IFI27 24695788 2948365 Negative_regulation CDK13 IFI27 24955023 680049 Negative_regulation CDK13 IFI27 25141103 1129046 Negative_regulation CDK13 IFI27 25278894 954843 Negative_regulation CDK13 IFI27 25321482 578475 Negative_regulation CDK13 IFI27 25351620 1887134 Negative_regulation CDK13 IFI27 25565868 2123766 Negative_regulation CDK13 IFI27 9155043 446206 Negative_regulation CDK13 IFI27 PMC3871896 1136494 Negative_regulation CDK13 IFI27 PMC4033971 2245931 Negative_regulation CDK13 MAP2K6 23804146 799996 Negative_regulation CDK14 CCND1 20334671 255694 Negative_regulation CDK14 CCND1 21124766 2484073 Negative_regulation CDK14 CCND1 22684298 541507 Negative_regulation CDK14 CCND1 22684298 541540 Negative_regulation CDK14 CCND1 22839099 265521 Negative_regulation CDK14 CCND1 23029062 2694443 Negative_regulation CDK14 CDKN1C 10390005 414578 Negative_regulation CDK14 CDKN1C 10424746 415058 Negative_regulation CDK14 CDKN1C 10698719 789671 Negative_regulation CDK14 CDKN1C 10944603 417408 Negative_regulation CDK14 CDKN1C 17020917 2023114 Negative_regulation CDK14 CDKN1C 17459161 3108295 Negative_regulation CDK14 CDKN1C 17505532 2376097 Negative_regulation CDK14 CDKN1C 20573229 2220874 Negative_regulation CDK14 CDKN1C 20596014 1985526 Negative_regulation CDK14 CDKN1C 21042410 2479597 Negative_regulation CDK14 CDKN1C 21504908 738975 Negative_regulation CDK14 CDKN1C 21801602 623882 Negative_regulation CDK14 CDKN1C 22920283 291088 Negative_regulation CDK14 CDKN1C 23231927 3226538 Negative_regulation CDK14 CDKN1C 24039437 2121673 Negative_regulation CDK14 CDKN1C 24389287 2186480 Negative_regulation CDK14 CDKN1C 25408871 608428 Negative_regulation CDK14 DAPK1 25226156 3007683 Negative_regulation CDK14 EPHB2 23609496 1105992 Negative_regulation CDK14 EPHB2 23936173 2829602 Negative_regulation CDK14 IFI27 11259087 418385 Negative_regulation CDK14 IFI27 11309409 1269484 Negative_regulation CDK14 IFI27 11309409 1269485 Negative_regulation CDK14 IFI27 14981092 1306402 Negative_regulation CDK14 IFI27 18060053 2381078 Negative_regulation CDK14 IFI27 18551186 3072518 Negative_regulation CDK14 IFI27 19079338 2124159 Negative_regulation CDK14 IFI27 19660140 584145 Negative_regulation CDK14 IFI27 19664228 584199 Negative_regulation CDK14 IFI27 20049729 774443 Negative_regulation CDK14 IFI27 20831799 375772 Negative_regulation CDK14 IFI27 22087251 2570781 Negative_regulation CDK14 IFI27 22733130 2147459 Negative_regulation CDK14 IFI27 23801714 727628 Negative_regulation CDK14 IFI27 23896637 1150436 Negative_regulation CDK14 IFI27 24586821 2927201 Negative_regulation CDK14 IFI27 24695788 2948381 Negative_regulation CDK14 IFI27 24955023 680085 Negative_regulation CDK14 IFI27 25141103 1129063 Negative_regulation CDK14 IFI27 25278894 954859 Negative_regulation CDK14 IFI27 25321482 578531 Negative_regulation CDK14 IFI27 25351620 1887166 Negative_regulation CDK14 IFI27 25565868 2123798 Negative_regulation CDK14 IFI27 9155043 446223 Negative_regulation CDK14 IFI27 PMC3871896 1136558 Negative_regulation CDK14 IFI27 PMC4033971 2245947 Negative_regulation CDK14 MAP2K6 23804146 800108 Negative_regulation CDK15 CCND1 20334671 255657 Negative_regulation CDK15 CCND1 21124766 2484037 Negative_regulation CDK15 CCND1 22684298 541483 Negative_regulation CDK15 CCND1 22684298 541521 Negative_regulation CDK15 CCND1 22839099 265485 Negative_regulation CDK15 CCND1 23029062 2694389 Negative_regulation CDK15 CDKN1C 10390005 414560 Negative_regulation CDK15 CDKN1C 10424746 415038 Negative_regulation CDK15 CDKN1C 10698719 789653 Negative_regulation CDK15 CDKN1C 10944603 417390 Negative_regulation CDK15 CDKN1C 17020917 2023096 Negative_regulation CDK15 CDKN1C 17459161 3108259 Negative_regulation CDK15 CDKN1C 17505532 2376079 Negative_regulation CDK15 CDKN1C 20573229 2220856 Negative_regulation CDK15 CDKN1C 20596014 1985508 Negative_regulation CDK15 CDKN1C 21042410 2479578 Negative_regulation CDK15 CDKN1C 21504908 738957 Negative_regulation CDK15 CDKN1C 21801602 623864 Negative_regulation CDK15 CDKN1C 22920283 291070 Negative_regulation CDK15 CDKN1C 23231927 3226520 Negative_regulation CDK15 CDKN1C 24039437 2121619 Negative_regulation CDK15 CDKN1C 24389287 2186462 Negative_regulation CDK15 CDKN1C 25408871 608410 Negative_regulation CDK15 DAPK1 25226156 3007647 Negative_regulation CDK15 EPHB2 23609496 1105974 Negative_regulation CDK15 EPHB2 23936173 2829583 Negative_regulation CDK15 IFI27 11259087 418367 Negative_regulation CDK15 IFI27 11309409 1269373 Negative_regulation CDK15 IFI27 11309409 1269374 Negative_regulation CDK15 IFI27 14981092 1306348 Negative_regulation CDK15 IFI27 18060053 2381060 Negative_regulation CDK15 IFI27 18551186 3072500 Negative_regulation CDK15 IFI27 19079338 2124123 Negative_regulation CDK15 IFI27 19660140 584127 Negative_regulation CDK15 IFI27 19664228 584163 Negative_regulation CDK15 IFI27 20049729 774407 Negative_regulation CDK15 IFI27 20831799 375735 Negative_regulation CDK15 IFI27 22087251 2570745 Negative_regulation CDK15 IFI27 22733130 2147439 Negative_regulation CDK15 IFI27 23801714 727567 Negative_regulation CDK15 IFI27 23896637 1150362 Negative_regulation CDK15 IFI27 24586821 2927165 Negative_regulation CDK15 IFI27 24695788 2948363 Negative_regulation CDK15 IFI27 24955023 680045 Negative_regulation CDK15 IFI27 25141103 1129044 Negative_regulation CDK15 IFI27 25278894 954841 Negative_regulation CDK15 IFI27 25321482 578471 Negative_regulation CDK15 IFI27 25351620 1887130 Negative_regulation CDK15 IFI27 25565868 2123762 Negative_regulation CDK15 IFI27 9155043 446204 Negative_regulation CDK15 IFI27 PMC3871896 1136486 Negative_regulation CDK15 IFI27 PMC4033971 2245929 Negative_regulation CDK15 MAP2K6 23804146 799982 Negative_regulation CDK16 CCND1 20334671 255688 Negative_regulation CDK16 CCND1 21124766 2484067 Negative_regulation CDK16 CCND1 22684298 541504 Negative_regulation CDK16 CCND1 22684298 541537 Negative_regulation CDK16 CCND1 22839099 265515 Negative_regulation CDK16 CCND1 23029062 2694434 Negative_regulation CDK16 CDKN1C 10390005 414575 Negative_regulation CDK16 CDKN1C 10424746 415055 Negative_regulation CDK16 CDKN1C 10698719 789668 Negative_regulation CDK16 CDKN1C 10944603 417405 Negative_regulation CDK16 CDKN1C 17020917 2023111 Negative_regulation CDK16 CDKN1C 17459161 3108289 Negative_regulation CDK16 CDKN1C 17505532 2376094 Negative_regulation CDK16 CDKN1C 20573229 2220871 Negative_regulation CDK16 CDKN1C 20596014 1985523 Negative_regulation CDK16 CDKN1C 21042410 2479594 Negative_regulation CDK16 CDKN1C 21504908 738972 Negative_regulation CDK16 CDKN1C 21801602 623879 Negative_regulation CDK16 CDKN1C 22920283 291085 Negative_regulation CDK16 CDKN1C 23231927 3226535 Negative_regulation CDK16 CDKN1C 24039437 2121664 Negative_regulation CDK16 CDKN1C 24389287 2186477 Negative_regulation CDK16 CDKN1C 25408871 608425 Negative_regulation CDK16 DAPK1 25226156 3007677 Negative_regulation CDK16 EPHB2 23609496 1105989 Negative_regulation CDK16 EPHB2 23936173 2829599 Negative_regulation CDK16 IFI27 11259087 418382 Negative_regulation CDK16 IFI27 11309409 1269466 Negative_regulation CDK16 IFI27 11309409 1269467 Negative_regulation CDK16 IFI27 14981092 1306393 Negative_regulation CDK16 IFI27 18060053 2381075 Negative_regulation CDK16 IFI27 18551186 3072515 Negative_regulation CDK16 IFI27 19079338 2124153 Negative_regulation CDK16 IFI27 19660140 584142 Negative_regulation CDK16 IFI27 19664228 584193 Negative_regulation CDK16 IFI27 20049729 774437 Negative_regulation CDK16 IFI27 20831799 375766 Negative_regulation CDK16 IFI27 22087251 2570775 Negative_regulation CDK16 IFI27 22733130 2147456 Negative_regulation CDK16 IFI27 23801714 727619 Negative_regulation CDK16 IFI27 23896637 1150424 Negative_regulation CDK16 IFI27 24586821 2927195 Negative_regulation CDK16 IFI27 24695788 2948378 Negative_regulation CDK16 IFI27 24955023 680079 Negative_regulation CDK16 IFI27 25141103 1129060 Negative_regulation CDK16 IFI27 25278894 954856 Negative_regulation CDK16 IFI27 25321482 578525 Negative_regulation CDK16 IFI27 25351620 1887160 Negative_regulation CDK16 IFI27 25565868 2123792 Negative_regulation CDK16 IFI27 9155043 446220 Negative_regulation CDK16 IFI27 PMC3871896 1136546 Negative_regulation CDK16 IFI27 PMC4033971 2245944 Negative_regulation CDK16 MAP2K6 23804146 800087 Negative_regulation CDK17 CCND1 20334671 255690 Negative_regulation CDK17 CCND1 21124766 2484069 Negative_regulation CDK17 CCND1 22684298 541505 Negative_regulation CDK17 CCND1 22684298 541538 Negative_regulation CDK17 CCND1 22839099 265517 Negative_regulation CDK17 CCND1 23029062 2694437 Negative_regulation CDK17 CDKN1C 10390005 414576 Negative_regulation CDK17 CDKN1C 10424746 415056 Negative_regulation CDK17 CDKN1C 10698719 789669 Negative_regulation CDK17 CDKN1C 10944603 417406 Negative_regulation CDK17 CDKN1C 17020917 2023112 Negative_regulation CDK17 CDKN1C 17459161 3108291 Negative_regulation CDK17 CDKN1C 17505532 2376095 Negative_regulation CDK17 CDKN1C 20573229 2220872 Negative_regulation CDK17 CDKN1C 20596014 1985524 Negative_regulation CDK17 CDKN1C 21042410 2479595 Negative_regulation CDK17 CDKN1C 21504908 738973 Negative_regulation CDK17 CDKN1C 21801602 623880 Negative_regulation CDK17 CDKN1C 22920283 291086 Negative_regulation CDK17 CDKN1C 23231927 3226536 Negative_regulation CDK17 CDKN1C 24039437 2121667 Negative_regulation CDK17 CDKN1C 24389287 2186478 Negative_regulation CDK17 CDKN1C 25408871 608426 Negative_regulation CDK17 DAPK1 25226156 3007679 Negative_regulation CDK17 EPHB2 23609496 1105990 Negative_regulation CDK17 EPHB2 23936173 2829600 Negative_regulation CDK17 IFI27 11259087 418383 Negative_regulation CDK17 IFI27 11309409 1269472 Negative_regulation CDK17 IFI27 11309409 1269473 Negative_regulation CDK17 IFI27 14981092 1306396 Negative_regulation CDK17 IFI27 18060053 2381076 Negative_regulation CDK17 IFI27 18551186 3072516 Negative_regulation CDK17 IFI27 19079338 2124155 Negative_regulation CDK17 IFI27 19660140 584143 Negative_regulation CDK17 IFI27 19664228 584195 Negative_regulation CDK17 IFI27 20049729 774439 Negative_regulation CDK17 IFI27 20831799 375768 Negative_regulation CDK17 IFI27 22087251 2570777 Negative_regulation CDK17 IFI27 22733130 2147457 Negative_regulation CDK17 IFI27 23801714 727622 Negative_regulation CDK17 IFI27 23896637 1150428 Negative_regulation CDK17 IFI27 24586821 2927197 Negative_regulation CDK17 IFI27 24695788 2948379 Negative_regulation CDK17 IFI27 24955023 680081 Negative_regulation CDK17 IFI27 25141103 1129061 Negative_regulation CDK17 IFI27 25278894 954857 Negative_regulation CDK17 IFI27 25321482 578527 Negative_regulation CDK17 IFI27 25351620 1887162 Negative_regulation CDK17 IFI27 25565868 2123794 Negative_regulation CDK17 IFI27 9155043 446221 Negative_regulation CDK17 IFI27 PMC3871896 1136550 Negative_regulation CDK17 IFI27 PMC4033971 2245945 Negative_regulation CDK17 MAP2K6 23804146 800094 Negative_regulation CDK18 CCND1 20334671 255692 Negative_regulation CDK18 CCND1 21124766 2484071 Negative_regulation CDK18 CCND1 22684298 541506 Negative_regulation CDK18 CCND1 22684298 541539 Negative_regulation CDK18 CCND1 22839099 265519 Negative_regulation CDK18 CCND1 23029062 2694440 Negative_regulation CDK18 CDKN1C 10390005 414577 Negative_regulation CDK18 CDKN1C 10424746 415057 Negative_regulation CDK18 CDKN1C 10698719 789670 Negative_regulation CDK18 CDKN1C 10944603 417407 Negative_regulation CDK18 CDKN1C 17020917 2023113 Negative_regulation CDK18 CDKN1C 17459161 3108293 Negative_regulation CDK18 CDKN1C 17505532 2376096 Negative_regulation CDK18 CDKN1C 20573229 2220873 Negative_regulation CDK18 CDKN1C 20596014 1985525 Negative_regulation CDK18 CDKN1C 21042410 2479596 Negative_regulation CDK18 CDKN1C 21504908 738974 Negative_regulation CDK18 CDKN1C 21801602 623881 Negative_regulation CDK18 CDKN1C 22920283 291087 Negative_regulation CDK18 CDKN1C 23231927 3226537 Negative_regulation CDK18 CDKN1C 24039437 2121670 Negative_regulation CDK18 CDKN1C 24389287 2186479 Negative_regulation CDK18 CDKN1C 25408871 608427 Negative_regulation CDK18 DAPK1 25226156 3007681 Negative_regulation CDK18 EPHB2 23609496 1105991 Negative_regulation CDK18 EPHB2 23936173 2829601 Negative_regulation CDK18 IFI27 11259087 418384 Negative_regulation CDK18 IFI27 11309409 1269478 Negative_regulation CDK18 IFI27 11309409 1269479 Negative_regulation CDK18 IFI27 14981092 1306399 Negative_regulation CDK18 IFI27 18060053 2381077 Negative_regulation CDK18 IFI27 18551186 3072517 Negative_regulation CDK18 IFI27 19079338 2124157 Negative_regulation CDK18 IFI27 19660140 584144 Negative_regulation CDK18 IFI27 19664228 584197 Negative_regulation CDK18 IFI27 20049729 774441 Negative_regulation CDK18 IFI27 20831799 375770 Negative_regulation CDK18 IFI27 22087251 2570779 Negative_regulation CDK18 IFI27 22733130 2147458 Negative_regulation CDK18 IFI27 23801714 727625 Negative_regulation CDK18 IFI27 23896637 1150432 Negative_regulation CDK18 IFI27 24586821 2927199 Negative_regulation CDK18 IFI27 24695788 2948380 Negative_regulation CDK18 IFI27 24955023 680083 Negative_regulation CDK18 IFI27 25141103 1129062 Negative_regulation CDK18 IFI27 25278894 954858 Negative_regulation CDK18 IFI27 25321482 578529 Negative_regulation CDK18 IFI27 25351620 1887164 Negative_regulation CDK18 IFI27 25565868 2123796 Negative_regulation CDK18 IFI27 9155043 446222 Negative_regulation CDK18 IFI27 PMC3871896 1136554 Negative_regulation CDK18 IFI27 PMC4033971 2245946 Negative_regulation CDK18 MAP2K6 23804146 800101 Negative_regulation CDK19 CCND1 20334671 255682 Negative_regulation CDK19 CCND1 21124766 2484061 Negative_regulation CDK19 CCND1 22684298 541501 Negative_regulation CDK19 CCND1 22684298 541534 Negative_regulation CDK19 CCND1 22839099 265509 Negative_regulation CDK19 CCND1 23029062 2694425 Negative_regulation CDK19 CDKN1C 10390005 414572 Negative_regulation CDK19 CDKN1C 10424746 415052 Negative_regulation CDK19 CDKN1C 10698719 789665 Negative_regulation CDK19 CDKN1C 10944603 417402 Negative_regulation CDK19 CDKN1C 17020917 2023108 Negative_regulation CDK19 CDKN1C 17459161 3108283 Negative_regulation CDK19 CDKN1C 17505532 2376091 Negative_regulation CDK19 CDKN1C 20573229 2220868 Negative_regulation CDK19 CDKN1C 20596014 1985520 Negative_regulation CDK19 CDKN1C 21042410 2479591 Negative_regulation CDK19 CDKN1C 21504908 738969 Negative_regulation CDK19 CDKN1C 21801602 623876 Negative_regulation CDK19 CDKN1C 22920283 291082 Negative_regulation CDK19 CDKN1C 23231927 3226532 Negative_regulation CDK19 CDKN1C 24039437 2121655 Negative_regulation CDK19 CDKN1C 24389287 2186474 Negative_regulation CDK19 CDKN1C 25408871 608422 Negative_regulation CDK19 DAPK1 25226156 3007671 Negative_regulation CDK19 EPHB2 23609496 1105986 Negative_regulation CDK19 EPHB2 23936173 2829596 Negative_regulation CDK19 IFI27 11259087 418379 Negative_regulation CDK19 IFI27 11309409 1269448 Negative_regulation CDK19 IFI27 11309409 1269449 Negative_regulation CDK19 IFI27 14981092 1306384 Negative_regulation CDK19 IFI27 18060053 2381072 Negative_regulation CDK19 IFI27 18551186 3072512 Negative_regulation CDK19 IFI27 19079338 2124147 Negative_regulation CDK19 IFI27 19660140 584139 Negative_regulation CDK19 IFI27 19664228 584187 Negative_regulation CDK19 IFI27 20049729 774431 Negative_regulation CDK19 IFI27 20831799 375760 Negative_regulation CDK19 IFI27 22087251 2570769 Negative_regulation CDK19 IFI27 22733130 2147451 Negative_regulation CDK19 IFI27 23801714 727606 Negative_regulation CDK19 IFI27 23896637 1150410 Negative_regulation CDK19 IFI27 24586821 2927189 Negative_regulation CDK19 IFI27 24695788 2948375 Negative_regulation CDK19 IFI27 24955023 680069 Negative_regulation CDK19 IFI27 25141103 1129056 Negative_regulation CDK19 IFI27 25278894 954853 Negative_regulation CDK19 IFI27 25321482 578495 Negative_regulation CDK19 IFI27 25351620 1887154 Negative_regulation CDK19 IFI27 25565868 2123786 Negative_regulation CDK19 IFI27 9155043 446216 Negative_regulation CDK19 IFI27 PMC3871896 1136534 Negative_regulation CDK19 IFI27 PMC4033971 2245941 Negative_regulation CDK19 MAP2K6 23804146 800066 Negative_regulation CDK2 CCND1 16595007 3083282 Negative_regulation CDK2 CCND1 20010939 434128 Negative_regulation CDK2 CCND1 20334671 255665 Negative_regulation CDK2 CCND1 21124766 2484045 Negative_regulation CDK2 CCND1 22684298 541490 Negative_regulation CDK2 CCND1 22684298 541526 Negative_regulation CDK2 CCND1 22839099 265493 Negative_regulation CDK2 CCND1 23029062 2694401 Negative_regulation CDK2 CCND1 24884804 1874320 Negative_regulation CDK2 CCND1 25109503 3114692 Negative_regulation CDK2 CDKN1C 10390005 414564 Negative_regulation CDK2 CDKN1C 10424746 415042 Negative_regulation CDK2 CDKN1C 10698719 789657 Negative_regulation CDK2 CDKN1C 10944603 417394 Negative_regulation CDK2 CDKN1C 16207381 298603 Negative_regulation CDK2 CDKN1C 17020917 2023100 Negative_regulation CDK2 CDKN1C 17459161 3108267 Negative_regulation CDK2 CDKN1C 17505532 2376083 Negative_regulation CDK2 CDKN1C 20105280 303611 Negative_regulation CDK2 CDKN1C 20573229 2220860 Negative_regulation CDK2 CDKN1C 20596014 1985512 Negative_regulation CDK2 CDKN1C 21042410 2479582 Negative_regulation CDK2 CDKN1C 21483429 1900862 Negative_regulation CDK2 CDKN1C 21483429 1900893 Negative_regulation CDK2 CDKN1C 21483429 1900894 Negative_regulation CDK2 CDKN1C 21504908 738961 Negative_regulation CDK2 CDKN1C 21801602 623868 Negative_regulation CDK2 CDKN1C 22211105 1058750 Negative_regulation CDK2 CDKN1C 22918239 541790 Negative_regulation CDK2 CDKN1C 22920283 291074 Negative_regulation CDK2 CDKN1C 23055977 959069 Negative_regulation CDK2 CDKN1C 23231927 3226524 Negative_regulation CDK2 CDKN1C 23470457 543091 Negative_regulation CDK2 CDKN1C 23479461 2182488 Negative_regulation CDK2 CDKN1C 24039437 2121631 Negative_regulation CDK2 CDKN1C 24224175 184947 Negative_regulation CDK2 CDKN1C 24389287 2186466 Negative_regulation CDK2 CDKN1C 25408871 608414 Negative_regulation CDK2 DAPK1 25226156 3007655 Negative_regulation CDK2 EPHB2 23609496 1105978 Negative_regulation CDK2 EPHB2 23936173 2829587 Negative_regulation CDK2 FAS 23017148 266310 Negative_regulation CDK2 FOXO1 21931533 2277062 Negative_regulation CDK2 IFI27 10188908 414134 Negative_regulation CDK2 IFI27 10389977 414447 Negative_regulation CDK2 IFI27 11259087 418371 Negative_regulation CDK2 IFI27 11309409 1269400 Negative_regulation CDK2 IFI27 11309409 1269401 Negative_regulation CDK2 IFI27 11381079 1270243 Negative_regulation CDK2 IFI27 14979923 458324 Negative_regulation CDK2 IFI27 14981092 1306360 Negative_regulation CDK2 IFI27 15603588 277965 Negative_regulation CDK2 IFI27 16759374 579874 Negative_regulation CDK2 IFI27 17088910 428306 Negative_regulation CDK2 IFI27 17088910 428349 Negative_regulation CDK2 IFI27 17088910 428358 Negative_regulation CDK2 IFI27 17764562 461010 Negative_regulation CDK2 IFI27 18060053 2381064 Negative_regulation CDK2 IFI27 18069898 2304624 Negative_regulation CDK2 IFI27 18182109 1891038 Negative_regulation CDK2 IFI27 18208615 480463 Negative_regulation CDK2 IFI27 18551186 3072504 Negative_regulation CDK2 IFI27 19079338 2124131 Negative_regulation CDK2 IFI27 19566963 583887 Negative_regulation CDK2 IFI27 19660140 584131 Negative_regulation CDK2 IFI27 19664228 584171 Negative_regulation CDK2 IFI27 19665013 698139 Negative_regulation CDK2 IFI27 19706164 1851290 Negative_regulation CDK2 IFI27 20049729 774415 Negative_regulation CDK2 IFI27 20359370 584764 Negative_regulation CDK2 IFI27 20504359 1676880 Negative_regulation CDK2 IFI27 20831799 375744 Negative_regulation CDK2 IFI27 20876711 716608 Negative_regulation CDK2 IFI27 21103079 2114975 Negative_regulation CDK2 IFI27 21182779 243896 Negative_regulation CDK2 IFI27 21197465 3127782 Negative_regulation CDK2 IFI27 21424700 1148115 Negative_regulation CDK2 IFI27 21526108 1685638 Negative_regulation CDK2 IFI27 21709748 3218252 Negative_regulation CDK2 IFI27 21827643 1862953 Negative_regulation CDK2 IFI27 21966251 678335 Negative_regulation CDK2 IFI27 22053771 334349 Negative_regulation CDK2 IFI27 22069713 3183562 Negative_regulation CDK2 IFI27 22087251 2570753 Negative_regulation CDK2 IFI27 22158041 2144801 Negative_regulation CDK2 IFI27 22219645 1913673 Negative_regulation CDK2 IFI27 22238675 2586900 Negative_regulation CDK2 IFI27 22479209 2334462 Negative_regulation CDK2 IFI27 22514746 2620020 Negative_regulation CDK2 IFI27 22577380 1072981 Negative_regulation CDK2 IFI27 22733130 2147443 Negative_regulation CDK2 IFI27 22932419 406793 Negative_regulation CDK2 IFI27 23029392 2697102 Negative_regulation CDK2 IFI27 23130001 960185 Negative_regulation CDK2 IFI27 23607100 181452 Negative_regulation CDK2 IFI27 23801714 727580 Negative_regulation CDK2 IFI27 23843721 648449 Negative_regulation CDK2 IFI27 23894465 2824811 Negative_regulation CDK2 IFI27 23896637 1150378 Negative_regulation CDK2 IFI27 24107298 2212319 Negative_regulation CDK2 IFI27 24179503 2166077 Negative_regulation CDK2 IFI27 24419005 502720 Negative_regulation CDK2 IFI27 24490161 186680 Negative_regulation CDK2 IFI27 24493742 2250583 Negative_regulation CDK2 IFI27 24586821 2927173 Negative_regulation CDK2 IFI27 24695788 2948367 Negative_regulation CDK2 IFI27 24811221 2190596 Negative_regulation CDK2 IFI27 24955023 680053 Negative_regulation CDK2 IFI27 25141103 1129048 Negative_regulation CDK2 IFI27 25278894 954845 Negative_regulation CDK2 IFI27 25299698 3014143 Negative_regulation CDK2 IFI27 25321482 578479 Negative_regulation CDK2 IFI27 25351620 1887138 Negative_regulation CDK2 IFI27 25565868 2123770 Negative_regulation CDK2 IFI27 7559780 1437317 Negative_regulation CDK2 IFI27 7577470 444050 Negative_regulation CDK2 IFI27 7642695 1438092 Negative_regulation CDK2 IFI27 8760794 1598726 Negative_regulation CDK2 IFI27 9155043 446208 Negative_regulation CDK2 IFI27 9218727 446391 Negative_regulation CDK2 IFI27 9472642 446901 Negative_regulation CDK2 IFI27 9679152 1469040 Negative_regulation CDK2 IFI27 PMC3871896 1136502 Negative_regulation CDK2 IFI27 PMC4033971 2245933 Negative_regulation CDK2 IFI27 PMC4185361 787281 Negative_regulation CDK2 MAP2K6 23804146 800010 Negative_regulation CDK2 S100B 25536222 3035755 Negative_regulation CDK20 CCND1 20334671 255684 Negative_regulation CDK20 CCND1 21124766 2484063 Negative_regulation CDK20 CCND1 22684298 541502 Negative_regulation CDK20 CCND1 22684298 541535 Negative_regulation CDK20 CCND1 22839099 265511 Negative_regulation CDK20 CCND1 23029062 2694428 Negative_regulation CDK20 CDKN1C 10390005 414573 Negative_regulation CDK20 CDKN1C 10424746 415053 Negative_regulation CDK20 CDKN1C 10698719 789666 Negative_regulation CDK20 CDKN1C 10944603 417403 Negative_regulation CDK20 CDKN1C 17020917 2023109 Negative_regulation CDK20 CDKN1C 17459161 3108285 Negative_regulation CDK20 CDKN1C 17505532 2376092 Negative_regulation CDK20 CDKN1C 20573229 2220869 Negative_regulation CDK20 CDKN1C 20596014 1985521 Negative_regulation CDK20 CDKN1C 21042410 2479592 Negative_regulation CDK20 CDKN1C 21504908 738970 Negative_regulation CDK20 CDKN1C 21801602 623877 Negative_regulation CDK20 CDKN1C 22920283 291083 Negative_regulation CDK20 CDKN1C 23231927 3226533 Negative_regulation CDK20 CDKN1C 24039437 2121658 Negative_regulation CDK20 CDKN1C 24389287 2186475 Negative_regulation CDK20 CDKN1C 25408871 608423 Negative_regulation CDK20 DAPK1 25226156 3007673 Negative_regulation CDK20 EPHB2 23609496 1105987 Negative_regulation CDK20 EPHB2 23936173 2829597 Negative_regulation CDK20 IFI27 11259087 418380 Negative_regulation CDK20 IFI27 11309409 1269454 Negative_regulation CDK20 IFI27 11309409 1269455 Negative_regulation CDK20 IFI27 14981092 1306387 Negative_regulation CDK20 IFI27 18060053 2381073 Negative_regulation CDK20 IFI27 18551186 3072513 Negative_regulation CDK20 IFI27 19079338 2124149 Negative_regulation CDK20 IFI27 19660140 584140 Negative_regulation CDK20 IFI27 19664228 584189 Negative_regulation CDK20 IFI27 20049729 774433 Negative_regulation CDK20 IFI27 20831799 375762 Negative_regulation CDK20 IFI27 22087251 2570771 Negative_regulation CDK20 IFI27 22733130 2147452 Negative_regulation CDK20 IFI27 23801714 727609 Negative_regulation CDK20 IFI27 23896637 1150414 Negative_regulation CDK20 IFI27 24586821 2927191 Negative_regulation CDK20 IFI27 24695788 2948376 Negative_regulation CDK20 IFI27 24955023 680071 Negative_regulation CDK20 IFI27 25141103 1129057 Negative_regulation CDK20 IFI27 25278894 954854 Negative_regulation CDK20 IFI27 25321482 578497 Negative_regulation CDK20 IFI27 25351620 1887156 Negative_regulation CDK20 IFI27 25565868 2123788 Negative_regulation CDK20 IFI27 9155043 446217 Negative_regulation CDK20 IFI27 PMC3871896 1136538 Negative_regulation CDK20 IFI27 PMC4033971 2245942 Negative_regulation CDK20 MAP2K6 23804146 800073 Negative_regulation CDK3 CCND1 20334671 255667 Negative_regulation CDK3 CCND1 21124766 2484047 Negative_regulation CDK3 CCND1 22684298 541494 Negative_regulation CDK3 CCND1 22684298 541527 Negative_regulation CDK3 CCND1 22839099 265495 Negative_regulation CDK3 CCND1 23029062 2694404 Negative_regulation CDK3 CDKN1C 10390005 414565 Negative_regulation CDK3 CDKN1C 10424746 415043 Negative_regulation CDK3 CDKN1C 10698719 789658 Negative_regulation CDK3 CDKN1C 10944603 417395 Negative_regulation CDK3 CDKN1C 17020917 2023101 Negative_regulation CDK3 CDKN1C 17459161 3108269 Negative_regulation CDK3 CDKN1C 17505532 2376084 Negative_regulation CDK3 CDKN1C 20573229 2220861 Negative_regulation CDK3 CDKN1C 20596014 1985513 Negative_regulation CDK3 CDKN1C 21042410 2479583 Negative_regulation CDK3 CDKN1C 21504908 738962 Negative_regulation CDK3 CDKN1C 21801602 623869 Negative_regulation CDK3 CDKN1C 22920283 291075 Negative_regulation CDK3 CDKN1C 23231927 3226525 Negative_regulation CDK3 CDKN1C 24039437 2121634 Negative_regulation CDK3 CDKN1C 24389287 2186467 Negative_regulation CDK3 CDKN1C 25408871 608415 Negative_regulation CDK3 DAPK1 25226156 3007657 Negative_regulation CDK3 EPHB2 23609496 1105979 Negative_regulation CDK3 EPHB2 23936173 2829588 Negative_regulation CDK3 IFI27 11259087 418372 Negative_regulation CDK3 IFI27 11309409 1269406 Negative_regulation CDK3 IFI27 11309409 1269407 Negative_regulation CDK3 IFI27 14981092 1306363 Negative_regulation CDK3 IFI27 18060053 2381065 Negative_regulation CDK3 IFI27 18551186 3072505 Negative_regulation CDK3 IFI27 19079338 2124133 Negative_regulation CDK3 IFI27 19660140 584132 Negative_regulation CDK3 IFI27 19664228 584173 Negative_regulation CDK3 IFI27 20049729 774417 Negative_regulation CDK3 IFI27 20831799 375746 Negative_regulation CDK3 IFI27 22087251 2570755 Negative_regulation CDK3 IFI27 22733130 2147444 Negative_regulation CDK3 IFI27 23801714 727583 Negative_regulation CDK3 IFI27 23896637 1150382 Negative_regulation CDK3 IFI27 24586821 2927175 Negative_regulation CDK3 IFI27 24695788 2948368 Negative_regulation CDK3 IFI27 24955023 680055 Negative_regulation CDK3 IFI27 25141103 1129049 Negative_regulation CDK3 IFI27 25278894 954846 Negative_regulation CDK3 IFI27 25321482 578481 Negative_regulation CDK3 IFI27 25351620 1887140 Negative_regulation CDK3 IFI27 25565868 2123772 Negative_regulation CDK3 IFI27 9155043 446209 Negative_regulation CDK3 IFI27 PMC3871896 1136506 Negative_regulation CDK3 IFI27 PMC4033971 2245934 Negative_regulation CDK3 MAP2K6 23804146 800017 Negative_regulation CDK4 CCND1 18764945 583279 Negative_regulation CDK4 CCND1 20334671 255669 Negative_regulation CDK4 CCND1 20398364 1853916 Negative_regulation CDK4 CCND1 21124766 2484049 Negative_regulation CDK4 CCND1 22684298 541495 Negative_regulation CDK4 CCND1 22684298 541528 Negative_regulation CDK4 CCND1 22839099 265497 Negative_regulation CDK4 CCND1 23029062 2694407 Negative_regulation CDK4 CCND1 23181557 292642 Negative_regulation CDK4 CCND1 24953629 1942808 Negative_regulation CDK4 CCND1 25109503 3114693 Negative_regulation CDK4 CDKN1C 10390005 414566 Negative_regulation CDK4 CDKN1C 10424746 415045 Negative_regulation CDK4 CDKN1C 10698719 789659 Negative_regulation CDK4 CDKN1C 10944603 417396 Negative_regulation CDK4 CDKN1C 16207381 298604 Negative_regulation CDK4 CDKN1C 17020917 2023102 Negative_regulation CDK4 CDKN1C 17459161 3108271 Negative_regulation CDK4 CDKN1C 17505532 2376085 Negative_regulation CDK4 CDKN1C 20573229 2220862 Negative_regulation CDK4 CDKN1C 20596014 1985514 Negative_regulation CDK4 CDKN1C 21042410 2479584 Negative_regulation CDK4 CDKN1C 21504908 738963 Negative_regulation CDK4 CDKN1C 21801602 623870 Negative_regulation CDK4 CDKN1C 22920283 291076 Negative_regulation CDK4 CDKN1C 23231927 3226526 Negative_regulation CDK4 CDKN1C 24039437 2121637 Negative_regulation CDK4 CDKN1C 24389287 2186468 Negative_regulation CDK4 CDKN1C 25206495 2004816 Negative_regulation CDK4 CDKN1C 25408871 608416 Negative_regulation CDK4 DAPK1 25226156 3007659 Negative_regulation CDK4 EPHB2 23609496 1105980 Negative_regulation CDK4 EPHB2 23936173 2829589 Negative_regulation CDK4 FAS 23017148 266311 Negative_regulation CDK4 IFI27 10576664 415587 Negative_regulation CDK4 IFI27 11259087 418373 Negative_regulation CDK4 IFI27 11309409 1269412 Negative_regulation CDK4 IFI27 11309409 1269413 Negative_regulation CDK4 IFI27 11381079 1270244 Negative_regulation CDK4 IFI27 14981092 1306366 Negative_regulation CDK4 IFI27 17092340 580173 Negative_regulation CDK4 IFI27 17092340 580221 Negative_regulation CDK4 IFI27 18060053 2381066 Negative_regulation CDK4 IFI27 18551186 3072506 Negative_regulation CDK4 IFI27 19079338 2124135 Negative_regulation CDK4 IFI27 19660140 584133 Negative_regulation CDK4 IFI27 19664228 584175 Negative_regulation CDK4 IFI27 20049729 774419 Negative_regulation CDK4 IFI27 20504359 1676882 Negative_regulation CDK4 IFI27 20831799 375748 Negative_regulation CDK4 IFI27 20948989 2174561 Negative_regulation CDK4 IFI27 21966251 678337 Negative_regulation CDK4 IFI27 22087251 2570757 Negative_regulation CDK4 IFI27 22733130 2147445 Negative_regulation CDK4 IFI27 23130001 960189 Negative_regulation CDK4 IFI27 23801714 727586 Negative_regulation CDK4 IFI27 23843721 648451 Negative_regulation CDK4 IFI27 23896637 1150386 Negative_regulation CDK4 IFI27 24179503 2166078 Negative_regulation CDK4 IFI27 24586821 2927177 Negative_regulation CDK4 IFI27 24695788 2948369 Negative_regulation CDK4 IFI27 24955023 680057 Negative_regulation CDK4 IFI27 25141103 1129050 Negative_regulation CDK4 IFI27 25278894 954847 Negative_regulation CDK4 IFI27 25321482 578483 Negative_regulation CDK4 IFI27 25351620 1887142 Negative_regulation CDK4 IFI27 25565868 2123774 Negative_regulation CDK4 IFI27 9155043 446210 Negative_regulation CDK4 IFI27 PMC3871896 1136510 Negative_regulation CDK4 IFI27 PMC4033971 2245935 Negative_regulation CDK4 MAP2K6 23804146 800024 Negative_regulation CDK4 OSR1 24931004 1681264 Negative_regulation CDK5 CCND1 20334671 255671 Negative_regulation CDK5 CCND1 21124766 2484051 Negative_regulation CDK5 CCND1 22684298 541496 Negative_regulation CDK5 CCND1 22684298 541529 Negative_regulation CDK5 CCND1 22839099 265499 Negative_regulation CDK5 CCND1 23029062 2694410 Negative_regulation CDK5 CDKN1C 10390005 414567 Negative_regulation CDK5 CDKN1C 10424746 415047 Negative_regulation CDK5 CDKN1C 10698719 789660 Negative_regulation CDK5 CDKN1C 10944603 417397 Negative_regulation CDK5 CDKN1C 17020917 2023103 Negative_regulation CDK5 CDKN1C 17459161 3108273 Negative_regulation CDK5 CDKN1C 17505532 2376086 Negative_regulation CDK5 CDKN1C 20573229 2220863 Negative_regulation CDK5 CDKN1C 20596014 1985515 Negative_regulation CDK5 CDKN1C 21042410 2479585 Negative_regulation CDK5 CDKN1C 21504908 738964 Negative_regulation CDK5 CDKN1C 21801602 623871 Negative_regulation CDK5 CDKN1C 22920283 291077 Negative_regulation CDK5 CDKN1C 23231927 3226527 Negative_regulation CDK5 CDKN1C 24039437 2121640 Negative_regulation CDK5 CDKN1C 24389287 2186469 Negative_regulation CDK5 CDKN1C 25408871 608417 Negative_regulation CDK5 DAPK1 25226156 3007661 Negative_regulation CDK5 EPHB2 17156427 279406 Negative_regulation CDK5 EPHB2 23609496 1105981 Negative_regulation CDK5 EPHB2 23936173 2829590 Negative_regulation CDK5 IFI27 11259087 418374 Negative_regulation CDK5 IFI27 11309409 1269418 Negative_regulation CDK5 IFI27 11309409 1269419 Negative_regulation CDK5 IFI27 14981092 1306369 Negative_regulation CDK5 IFI27 18060053 2381067 Negative_regulation CDK5 IFI27 18551186 3072507 Negative_regulation CDK5 IFI27 19079338 2124137 Negative_regulation CDK5 IFI27 19660140 584134 Negative_regulation CDK5 IFI27 19664228 584177 Negative_regulation CDK5 IFI27 20049729 774421 Negative_regulation CDK5 IFI27 20831799 375750 Negative_regulation CDK5 IFI27 22087251 2570759 Negative_regulation CDK5 IFI27 22733130 2147446 Negative_regulation CDK5 IFI27 23801714 727589 Negative_regulation CDK5 IFI27 23896637 1150390 Negative_regulation CDK5 IFI27 24586821 2927179 Negative_regulation CDK5 IFI27 24695788 2948370 Negative_regulation CDK5 IFI27 24955023 680059 Negative_regulation CDK5 IFI27 25141103 1129051 Negative_regulation CDK5 IFI27 25278894 954848 Negative_regulation CDK5 IFI27 25321482 578485 Negative_regulation CDK5 IFI27 25351620 1887144 Negative_regulation CDK5 IFI27 25565868 2123776 Negative_regulation CDK5 IFI27 9155043 446211 Negative_regulation CDK5 IFI27 PMC3871896 1136514 Negative_regulation CDK5 IFI27 PMC4033971 2245936 Negative_regulation CDK5 MAP2K6 23804146 800031 Negative_regulation CDK5 NES 21278733 1966514 Negative_regulation CDK5 TNF 23668392 1899767 Negative_regulation CDK5R1 CCND1 22833568 1806165 Negative_regulation CDK6 CCND1 20334671 255673 Negative_regulation CDK6 CCND1 21124766 2484053 Negative_regulation CDK6 CCND1 22684298 541497 Negative_regulation CDK6 CCND1 22684298 541530 Negative_regulation CDK6 CCND1 22839099 265501 Negative_regulation CDK6 CCND1 23029062 2694413 Negative_regulation CDK6 CCND1 23181557 292644 Negative_regulation CDK6 CCND1 24953629 1942810 Negative_regulation CDK6 CDKN1C 10390005 414568 Negative_regulation CDK6 CDKN1C 10424746 415048 Negative_regulation CDK6 CDKN1C 10698719 789661 Negative_regulation CDK6 CDKN1C 10944603 417398 Negative_regulation CDK6 CDKN1C 17020917 2023104 Negative_regulation CDK6 CDKN1C 17459161 3108275 Negative_regulation CDK6 CDKN1C 17505532 2376087 Negative_regulation CDK6 CDKN1C 20573229 2220864 Negative_regulation CDK6 CDKN1C 20596014 1985516 Negative_regulation CDK6 CDKN1C 21042410 2479586 Negative_regulation CDK6 CDKN1C 21504908 738965 Negative_regulation CDK6 CDKN1C 21801602 623872 Negative_regulation CDK6 CDKN1C 22920283 291078 Negative_regulation CDK6 CDKN1C 23231927 3226528 Negative_regulation CDK6 CDKN1C 24039437 2121643 Negative_regulation CDK6 CDKN1C 24389287 2186470 Negative_regulation CDK6 CDKN1C 25408871 608418 Negative_regulation CDK6 DAPK1 25226156 3007663 Negative_regulation CDK6 EPHB2 23609496 1105982 Negative_regulation CDK6 EPHB2 23936173 2829591 Negative_regulation CDK6 IFI27 11259087 418375 Negative_regulation CDK6 IFI27 11309409 1269424 Negative_regulation CDK6 IFI27 11309409 1269425 Negative_regulation CDK6 IFI27 14981092 1306372 Negative_regulation CDK6 IFI27 18060053 2381068 Negative_regulation CDK6 IFI27 18551186 3072508 Negative_regulation CDK6 IFI27 19079338 2124139 Negative_regulation CDK6 IFI27 19660140 584135 Negative_regulation CDK6 IFI27 19664228 584179 Negative_regulation CDK6 IFI27 20049729 774423 Negative_regulation CDK6 IFI27 20831799 375752 Negative_regulation CDK6 IFI27 22087251 2570761 Negative_regulation CDK6 IFI27 22733130 2147447 Negative_regulation CDK6 IFI27 23801714 727592 Negative_regulation CDK6 IFI27 23896637 1150394 Negative_regulation CDK6 IFI27 24586821 2927181 Negative_regulation CDK6 IFI27 24695788 2948371 Negative_regulation CDK6 IFI27 24955023 680061 Negative_regulation CDK6 IFI27 25141103 1129052 Negative_regulation CDK6 IFI27 25278894 954849 Negative_regulation CDK6 IFI27 25321482 578487 Negative_regulation CDK6 IFI27 25351620 1887146 Negative_regulation CDK6 IFI27 25565868 2123778 Negative_regulation CDK6 IFI27 9155043 446212 Negative_regulation CDK6 IFI27 PMC3871896 1136518 Negative_regulation CDK6 IFI27 PMC4033971 2245937 Negative_regulation CDK6 MAP2K6 23804146 800038 Negative_regulation CDK6 TFPI2 22761571 3057405 Negative_regulation CDK7 CCND1 20334671 255675 Negative_regulation CDK7 CCND1 21124766 2484055 Negative_regulation CDK7 CCND1 22684298 541498 Negative_regulation CDK7 CCND1 22684298 541531 Negative_regulation CDK7 CCND1 22839099 265503 Negative_regulation CDK7 CCND1 23029062 2694416 Negative_regulation CDK7 CDKN1C 10390005 414569 Negative_regulation CDK7 CDKN1C 10424746 415049 Negative_regulation CDK7 CDKN1C 10698719 789662 Negative_regulation CDK7 CDKN1C 10944603 417399 Negative_regulation CDK7 CDKN1C 17020917 2023105 Negative_regulation CDK7 CDKN1C 17459161 3108277 Negative_regulation CDK7 CDKN1C 17505532 2376088 Negative_regulation CDK7 CDKN1C 20573229 2220865 Negative_regulation CDK7 CDKN1C 20596014 1985517 Negative_regulation CDK7 CDKN1C 21042410 2479587 Negative_regulation CDK7 CDKN1C 21504908 738966 Negative_regulation CDK7 CDKN1C 21801602 623873 Negative_regulation CDK7 CDKN1C 22920283 291079 Negative_regulation CDK7 CDKN1C 23231927 3226529 Negative_regulation CDK7 CDKN1C 24039437 2121646 Negative_regulation CDK7 CDKN1C 24389287 2186471 Negative_regulation CDK7 CDKN1C 25408871 608419 Negative_regulation CDK7 DAPK1 25226156 3007665 Negative_regulation CDK7 EPHB2 23609496 1105983 Negative_regulation CDK7 EPHB2 23936173 2829592 Negative_regulation CDK7 IFI27 11259087 418376 Negative_regulation CDK7 IFI27 11309409 1269430 Negative_regulation CDK7 IFI27 11309409 1269431 Negative_regulation CDK7 IFI27 14981092 1306375 Negative_regulation CDK7 IFI27 18060053 2381069 Negative_regulation CDK7 IFI27 18551186 3072509 Negative_regulation CDK7 IFI27 19079338 2124141 Negative_regulation CDK7 IFI27 19660140 584136 Negative_regulation CDK7 IFI27 19664228 584181 Negative_regulation CDK7 IFI27 20049729 774425 Negative_regulation CDK7 IFI27 20831799 375754 Negative_regulation CDK7 IFI27 22087251 2570763 Negative_regulation CDK7 IFI27 22733130 2147448 Negative_regulation CDK7 IFI27 23801714 727595 Negative_regulation CDK7 IFI27 23896637 1150398 Negative_regulation CDK7 IFI27 24586821 2927183 Negative_regulation CDK7 IFI27 24695788 2948372 Negative_regulation CDK7 IFI27 24955023 680063 Negative_regulation CDK7 IFI27 25141103 1129053 Negative_regulation CDK7 IFI27 25278894 954850 Negative_regulation CDK7 IFI27 25321482 578489 Negative_regulation CDK7 IFI27 25351620 1887148 Negative_regulation CDK7 IFI27 25565868 2123780 Negative_regulation CDK7 IFI27 9155043 446213 Negative_regulation CDK7 IFI27 PMC3871896 1136522 Negative_regulation CDK7 IFI27 PMC4033971 2245938 Negative_regulation CDK7 MAP2K6 23804146 800045 Negative_regulation CDK8 CCND1 20334671 255677 Negative_regulation CDK8 CCND1 21124766 2484057 Negative_regulation CDK8 CCND1 22684298 541499 Negative_regulation CDK8 CCND1 22684298 541532 Negative_regulation CDK8 CCND1 22839099 265505 Negative_regulation CDK8 CCND1 23029062 2694419 Negative_regulation CDK8 CDKN1C 10390005 414570 Negative_regulation CDK8 CDKN1C 10424746 415050 Negative_regulation CDK8 CDKN1C 10698719 789663 Negative_regulation CDK8 CDKN1C 10944603 417400 Negative_regulation CDK8 CDKN1C 17020917 2023106 Negative_regulation CDK8 CDKN1C 17459161 3108279 Negative_regulation CDK8 CDKN1C 17505532 2376089 Negative_regulation CDK8 CDKN1C 20573229 2220866 Negative_regulation CDK8 CDKN1C 20596014 1985518 Negative_regulation CDK8 CDKN1C 21042410 2479588 Negative_regulation CDK8 CDKN1C 21504908 738967 Negative_regulation CDK8 CDKN1C 21801602 623874 Negative_regulation CDK8 CDKN1C 22920283 291080 Negative_regulation CDK8 CDKN1C 23231927 3226530 Negative_regulation CDK8 CDKN1C 24039437 2121649 Negative_regulation CDK8 CDKN1C 24389287 2186472 Negative_regulation CDK8 CDKN1C 25408871 608420 Negative_regulation CDK8 DAPK1 25226156 3007667 Negative_regulation CDK8 EPHB2 23609496 1105984 Negative_regulation CDK8 EPHB2 23936173 2829593 Negative_regulation CDK8 IFI27 11259087 418377 Negative_regulation CDK8 IFI27 11309409 1269436 Negative_regulation CDK8 IFI27 11309409 1269437 Negative_regulation CDK8 IFI27 14981092 1306378 Negative_regulation CDK8 IFI27 18060053 2381070 Negative_regulation CDK8 IFI27 18551186 3072510 Negative_regulation CDK8 IFI27 19079338 2124143 Negative_regulation CDK8 IFI27 19660140 584137 Negative_regulation CDK8 IFI27 19664228 584183 Negative_regulation CDK8 IFI27 20049729 774427 Negative_regulation CDK8 IFI27 20831799 375756 Negative_regulation CDK8 IFI27 22087251 2570765 Negative_regulation CDK8 IFI27 22733130 2147449 Negative_regulation CDK8 IFI27 23801714 727598 Negative_regulation CDK8 IFI27 23896637 1150402 Negative_regulation CDK8 IFI27 24586821 2927185 Negative_regulation CDK8 IFI27 24695788 2948373 Negative_regulation CDK8 IFI27 24955023 680065 Negative_regulation CDK8 IFI27 25141103 1129054 Negative_regulation CDK8 IFI27 25278894 954851 Negative_regulation CDK8 IFI27 25321482 578491 Negative_regulation CDK8 IFI27 25351620 1887150 Negative_regulation CDK8 IFI27 25565868 2123782 Negative_regulation CDK8 IFI27 9155043 446214 Negative_regulation CDK8 IFI27 PMC3871896 1136526 Negative_regulation CDK8 IFI27 PMC4033971 2245939 Negative_regulation CDK8 MAP2K6 21242991 1900784 Negative_regulation CDK8 MAP2K6 23804146 800052 Negative_regulation CDK9 CCND1 20334671 255679 Negative_regulation CDK9 CCND1 21124766 2484059 Negative_regulation CDK9 CCND1 22684298 541500 Negative_regulation CDK9 CCND1 22684298 541533 Negative_regulation CDK9 CCND1 22839099 265507 Negative_regulation CDK9 CCND1 23029062 2694422 Negative_regulation CDK9 CDKN1C 10390005 414571 Negative_regulation CDK9 CDKN1C 10424746 415051 Negative_regulation CDK9 CDKN1C 10698719 789664 Negative_regulation CDK9 CDKN1C 10944603 417401 Negative_regulation CDK9 CDKN1C 17020917 2023107 Negative_regulation CDK9 CDKN1C 17459161 3108281 Negative_regulation CDK9 CDKN1C 17505532 2376090 Negative_regulation CDK9 CDKN1C 20573229 2220867 Negative_regulation CDK9 CDKN1C 20596014 1985519 Negative_regulation CDK9 CDKN1C 21042410 2479589 Negative_regulation CDK9 CDKN1C 21504908 738968 Negative_regulation CDK9 CDKN1C 21801602 623875 Negative_regulation CDK9 CDKN1C 22920283 291081 Negative_regulation CDK9 CDKN1C 23231927 3226531 Negative_regulation CDK9 CDKN1C 24039437 2121652 Negative_regulation CDK9 CDKN1C 24389287 2186473 Negative_regulation CDK9 CDKN1C 25408871 608421 Negative_regulation CDK9 DAPK1 25226156 3007669 Negative_regulation CDK9 EPHB2 23609496 1105985 Negative_regulation CDK9 EPHB2 23936173 2829594 Negative_regulation CDK9 IFI27 11259087 418378 Negative_regulation CDK9 IFI27 11309409 1269442 Negative_regulation CDK9 IFI27 11309409 1269443 Negative_regulation CDK9 IFI27 14981092 1306381 Negative_regulation CDK9 IFI27 18060053 2381071 Negative_regulation CDK9 IFI27 18551186 3072511 Negative_regulation CDK9 IFI27 19079338 2124145 Negative_regulation CDK9 IFI27 19660140 584138 Negative_regulation CDK9 IFI27 19664228 584185 Negative_regulation CDK9 IFI27 20049729 774429 Negative_regulation CDK9 IFI27 20831799 375758 Negative_regulation CDK9 IFI27 22087251 2570767 Negative_regulation CDK9 IFI27 22733130 2147450 Negative_regulation CDK9 IFI27 23801714 727601 Negative_regulation CDK9 IFI27 23896637 1150406 Negative_regulation CDK9 IFI27 24586821 2927187 Negative_regulation CDK9 IFI27 24695788 2948374 Negative_regulation CDK9 IFI27 24955023 680067 Negative_regulation CDK9 IFI27 25141103 1129055 Negative_regulation CDK9 IFI27 25278894 954852 Negative_regulation CDK9 IFI27 25321482 578493 Negative_regulation CDK9 IFI27 25351620 1887152 Negative_regulation CDK9 IFI27 25565868 2123784 Negative_regulation CDK9 IFI27 9155043 446215 Negative_regulation CDK9 IFI27 PMC3871896 1136530 Negative_regulation CDK9 IFI27 PMC4033971 2245940 Negative_regulation CDK9 MAP2K6 23804146 800059 Negative_regulation CDK9 NR2F1 22651576 3112984 Negative_regulation CDK9 PGC 23173091 976282 Negative_regulation CDK9 RNASE1 17341462 2026617 Negative_regulation CDKN1A CAPN8 22432027 2611642 Negative_regulation CDKN1A CAPN8 22432027 2611670 Negative_regulation CDKN1A CCND1 16457690 459648 Negative_regulation CDKN1A CCND1 16512916 279074 Negative_regulation CDKN1A CCND1 16595007 3083285 Negative_regulation CDKN1A CCND1 18834508 583338 Negative_regulation CDKN1A CCND1 20334671 255681 Negative_regulation CDKN1A CCND1 20642839 1647227 Negative_regulation CDKN1A CCND1 20824095 2473724 Negative_regulation CDKN1A CCND1 21931726 2554275 Negative_regulation CDKN1A CCND1 22539978 2622735 Negative_regulation CDKN1A CCND1 22815774 2665999 Negative_regulation CDKN1A CCND1 22860097 2671580 Negative_regulation CDKN1A CCND1 22968658 788011 Negative_regulation CDKN1A CCND1 23181557 292646 Negative_regulation CDKN1A CCND1 23243436 816503 Negative_regulation CDKN1A CCND1 23390492 2750671 Negative_regulation CDKN1A CCND1 23390492 2750682 Negative_regulation CDKN1A CCND1 23390492 2750683 Negative_regulation CDKN1A CCND1 24004818 1618319 Negative_regulation CDKN1A CCND1 24006921 269672 Negative_regulation CDKN1A CCND1 24324549 2890737 Negative_regulation CDKN1A CCND1 24628936 539657 Negative_regulation CDKN1A CCND1 25296971 2204233 Negative_regulation CDKN1A CCND1 25309914 201076 Negative_regulation CDKN1A CCND1 PMC3300140 476963 Negative_regulation CDKN1A EPHB2 16351709 1844963 Negative_regulation CDKN1A EPHB2 16351709 1845034 Negative_regulation CDKN1A EPHB2 16879721 1163600 Negative_regulation CDKN1A EPHB2 21223585 258394 Negative_regulation CDKN1A EPHB2 21776388 1686265 Negative_regulation CDKN1A EPHB2 21904669 798918 Negative_regulation CDKN1A EPHB2 23155423 2717214 Negative_regulation CDKN1A EPHB2 23936173 2829595 Negative_regulation CDKN1A FAS 11870542 420569 Negative_regulation CDKN1A FAS 18523653 2390328 Negative_regulation CDKN1A HOXB2 20504375 1855518 Negative_regulation CDKN1A ID1 18092003 2381431 Negative_regulation CDKN1A ID1 18092003 2381432 Negative_regulation CDKN1A ID1 24620998 132056 Negative_regulation CDKN1A IFI27 23801714 727603 Negative_regulation CDKN1A IL1B 12928151 791899 Negative_regulation CDKN1A MAP2K6 10491389 1249434 Negative_regulation CDKN1A MAP2K6 16351709 1844969 Negative_regulation CDKN1A MAP2K6 16351709 1845040 Negative_regulation CDKN1A MAP2K6 20203690 546686 Negative_regulation CDKN1A MATN2 24691449 2947767 Negative_regulation CDKN1A OSR1 24931004 1681265 Negative_regulation CDKN1A OSR1 24931004 1681311 Negative_regulation CDKN1A TP63 24823795 2100837 Negative_regulation CDKN1B CCND1 12633504 479920 Negative_regulation CDKN1B CCND1 12633504 479942 Negative_regulation CDKN1B CCND1 21179458 2488029 Negative_regulation CDKN1B CCND1 21179458 2488048 Negative_regulation CDKN1B CCND1 21179458 2488049 Negative_regulation CDKN1B CCND1 21209944 2492523 Negative_regulation CDKN1B CDKN1C 17562792 1341257 Negative_regulation CDKN1B EGLN3 22087251 2570782 Negative_regulation CDKN1B EGLN3 23457600 2758969 Negative_regulation CDKN1B IFI27 25053875 1917166 Negative_regulation CDKN1B S100B 25536222 3035759 Negative_regulation CDKN1C BCL11A 23000964 1928615 Negative_regulation CDKN1C BCL11A 23000964 1928625 Negative_regulation CDKN1C BCL11B 22588081 771825 Negative_regulation CDKN1C CDKN1B 17562792 1341258 Negative_regulation CDKN1C DNMT1 24886104 3114604 Negative_regulation CDKN1C EWSR1 23329308 1734621 Negative_regulation CDKN1C EZH2 19340297 2411487 Negative_regulation CDKN1C EZH2 19340297 2411495 Negative_regulation CDKN1C EZH2 19340297 2411500 Negative_regulation CDKN1C FLI1 23329308 1734622 Negative_regulation CDKN1C HDAC1 24886104 3114605 Negative_regulation CDKN1C HDAC2 24886104 3114606 Negative_regulation CDKN1C HIST1H3H 19340297 2411501 Negative_regulation CDKN1C HLX 21547091 1683282 Negative_regulation CDKN1C ID2 19417068 2043693 Negative_regulation CDKN1C ID2 19417068 2043697 Negative_regulation CDKN1C INSM1 23000964 1928621 Negative_regulation CDKN1C KCNQ1OT1 15888726 2016390 Negative_regulation CDKN1C KCNQ1OT1 18958286 2399570 Negative_regulation CDKN1C KCNQ1OT1 23880895 606221 Negative_regulation CDKN1C MYLIP 21278784 12428 Negative_regulation CDKN1C MYLIP 21278784 12430 Negative_regulation CDKN1C MYLIP 21278784 12438 Negative_regulation CDKN1C MYLIP 22065734 514310 Negative_regulation CDKN1C MYLIP 25588980 1736381 Negative_regulation CDKN1C NOTCH1 21042410 2479633 Negative_regulation CDKN1C NOTCH2 21042410 2479634 Negative_regulation CDKN1C NOTCH3 21042410 2479635 Negative_regulation CDKN1C NOTCH4 21042410 2479636 Negative_regulation CDKN1C RBBP4 24886104 3114607 Negative_regulation CDKN1C RBBP7 24886104 3114608 Negative_regulation CDKN1C TP53 21042410 2479590 Negative_regulation CDKN1C TP53 21042410 2479598 Negative_regulation CDKN2A ID1 21836819 648290 Negative_regulation CDKN2A TLR7 23549168 543161 Negative_regulation CDKN2B CCND1 23320178 1065261 Negative_regulation CDKN2B CCND1 24628936 539659 Negative_regulation CDKN2B EPHB2 23237773 2181995 Negative_regulation CDO1 EPHB2 22298426 1799986 Negative_regulation CDO1 TNF 24553827 85148 Negative_regulation CEACAM5 CEACAM6 23941132 3113930 Negative_regulation CEACAM6 HNF1A 18028549 1848404 Negative_regulation CEACAM6 IL6 17764466 590511 Negative_regulation CEACAM6 LIF 22905257 2675845 Negative_regulation CEACAM6 SLC22A3 25398131 3027592 Negative_regulation CEBPD TNF 23525087 1958635 Negative_regulation CEBPZ EDN2 20388225 1891589 Negative_regulation CELF1 RNASE1 19443441 2046087 Negative_regulation CELF2 RNASE1 19443441 2046088 Negative_regulation CELF3 RNASE1 19443441 2046083 Negative_regulation CELF4 RNASE1 19443441 2046084 Negative_regulation CELF5 RNASE1 19443441 2046085 Negative_regulation CELF6 RNASE1 19443441 2046086 Negative_regulation CERS3 ELOVL4 23826266 2811877 Negative_regulation CFB CFI 23799019 2806687 Negative_regulation CFI CFB 23799019 2806688 Negative_regulation CFI PPP2CA 24395824 992896 Negative_regulation CFI PPP2R1A 24395824 992897 Negative_regulation CFI PPP2R2B 24395824 992898 Negative_regulation CFL1 IFI27 25452716 872539 Negative_regulation CFL1 IFI27 25452716 872542 Negative_regulation CFL2 IFI27 25452716 872540 Negative_regulation CFL2 IFI27 25452716 872543 Negative_regulation CFLAR FAS PMC2195999 1475379 Negative_regulation CFLAR TNFSF10 20663232 1857135 Negative_regulation CFLAR TNFSF10 25257790 1731037 Negative_regulation CFP TF 4040153 1583802 Negative_regulation CFTR CAPN8 23785472 2806287 Negative_regulation CFTR CAPN8 23785472 2806288 Negative_regulation CFTR CAPN8 23785472 2806305 Negative_regulation CFTR CAPN8 23785472 2806375 Negative_regulation CFTR MIP 21301926 1050351 Negative_regulation CFTR TNF 21301926 1050342 Negative_regulation CGA TNF 21179488 2488350 Negative_regulation CGB8 TNF 21179488 2488349 Negative_regulation CHAT TNF 23840379 2812656 Negative_regulation CHAT TNF 23840379 2812666 Negative_regulation CHAT WNT7A 25170755 3003896 Negative_regulation CHDH IL6R 24971337 193344 Negative_regulation CHGA RNASE1 25101113 896624 Negative_regulation CHGA RNASE7 25101113 896632 Negative_regulation CHI3L1 CTLA4 21403825 1219157 Negative_regulation CHI3L1 MYLIP 25358394 1946494 Negative_regulation CHI3L1 MYLIP 25358394 1946495 Negative_regulation CHI3L1 RELA 23451236 2758425 Negative_regulation CHI3L1 RELB 23451236 2758426 Negative_regulation CHI3L1 SCARNA5 24281168 501792 Negative_regulation CHI3L1 TNF 23451236 2758424 Negative_regulation CHI3L1 TRIAP1 21403825 1219158 Negative_regulation CHI3L1 VEGFA 23755018 961416 Negative_regulation CHKA GNE 24247149 545358 Negative_regulation CHKA GNE 24996846 274234 Negative_regulation CHKA MAP2K6 23085539 2181366 Negative_regulation CHUK EPHB2 22536447 2622522 Negative_regulation CHUK MAP2K6 22536447 2622528 Negative_regulation CHUK MAP2K6 23826126 2810284 Negative_regulation CHUK MMP28 22359588 2598026 Negative_regulation CHUK MMP7 22359588 2598042 Negative_regulation CHUK TNF 10359587 1511930 Negative_regulation CHUK TNF 22046421 2567708 Negative_regulation CHUK TNF 22351606 778110 Negative_regulation CHUK TNFSF10 20977779 257734 Negative_regulation CIB1 CCND1 10424746 415061 Negative_regulation CIB1 CCND1 19115995 1503529 Negative_regulation CIB1 CCND1 20642839 1647225 Negative_regulation CIB1 CCND1 20865053 2475147 Negative_regulation CIB1 CCND1 21909380 2551681 Negative_regulation CIB1 CCND1 23549262 1104722 Negative_regulation CIB1 CCND1 24004818 1618318 Negative_regulation CIB1 CDKN1C 17786216 2378014 Negative_regulation CIB1 EPHB2 17663798 320710 Negative_regulation CIB1 EPHB2 23237773 2181994 Negative_regulation CIB1 IFI27 14734530 1304591 Negative_regulation CISH CD14 21387014 2506175 Negative_regulation CISH JAG1 21124801 2484133 Negative_regulation CISH SYT8 22940675 1978132 Negative_regulation CKM TNF 24180420 3114225 Negative_regulation CLDN10 F11R 18039951 1547864 Negative_regulation CLDN10 F11R 18039951 1547865 Negative_regulation CLDN10 MAPK1 23430606 3184898 Negative_regulation CLDN10 MAPK10 23430606 3184899 Negative_regulation CLDN10 MAPK11 23430606 3184900 Negative_regulation CLDN10 MAPK12 23430606 3184901 Negative_regulation CLDN10 MAPK13 23430606 3184902 Negative_regulation CLDN10 MAPK14 23430606 3184903 Negative_regulation CLDN10 MAPK15 23430606 3184897 Negative_regulation CLDN10 MAPK3 23430606 3184904 Negative_regulation CLDN10 MAPK4 23430606 3184905 Negative_regulation CLDN10 MAPK6 23430606 3184906 Negative_regulation CLDN10 MAPK7 23430606 3184907 Negative_regulation CLDN10 MAPK8 23430606 3184908 Negative_regulation CLDN10 MAPK9 23430606 3184909 Negative_regulation CLDN10 MYLIP 22511979 2619170 Negative_regulation CLDN10 PAWR 24503536 571886 Negative_regulation CLDN10 TYR 22069652 3183258 Negative_regulation CLDN2 EPHB2 22767581 1805467 Negative_regulation CLDN2 EPHB2 22767581 1805472 Negative_regulation CLDN3 TNF 25096552 2252351 Negative_regulation CLDN4 TNF 25031428 1828838 Negative_regulation CLDN4 TNF 25031428 1828842 Negative_regulation CLDN5 PLAT 21151895 2485263 Negative_regulation CLDN5 TNF 20693346 716068 Negative_regulation CLDN5 TNF 23962089 1666961 Negative_regulation CLDN5 TNF 24992685 2986591 Negative_regulation CLTA TF 9314527 1463462 Negative_regulation CLTC TF 9314527 1463463 Negative_regulation CLU AR 25395862 2123721 Negative_regulation CLU CFB 21040564 3099626 Negative_regulation CLU CFTR 18368527 3086849 Negative_regulation CLU GP2 15987443 458885 Negative_regulation CLU GP2 18433489 361484 Negative_regulation CLU GP2 18433489 361486 Negative_regulation CLU GP2 18433489 361487 Negative_regulation CLU GP2 19903339 362371 Negative_regulation CLU GPR39 22545109 2623403 Negative_regulation CLU HDAC1 20920219 1859728 Negative_regulation CLU HDAC2 20920219 1859729 Negative_regulation CLU MECP2 20420693 386024 Negative_regulation CLU MECP2 20420693 386025 Negative_regulation CLU MYC 23362253 1206183 Negative_regulation CLU MYLIP 25038756 496514 Negative_regulation CLU NPPB 23189038 930858 Negative_regulation CLU PTGS2 25343247 3018995 Negative_regulation CLU SLC12A2 23144843 2714716 Negative_regulation CLU SLC12A2 24949446 192684 Negative_regulation CLU SLC12A5 24949446 192682 Negative_regulation CLU SLC12A7 24949446 192681 Negative_regulation CLU TGFB1 20981268 161972 Negative_regulation CLU TIMP3 23257616 31098 Negative_regulation CLU TP53 24672247 2122903 Negative_regulation CLU WNT1 17634137 1645546 Negative_regulation CLU WNT11 17634137 1645547 Negative_regulation CLU WNT16 17634137 1645552 Negative_regulation CLU WNT2 17634137 1645548 Negative_regulation CLU WNT3 17634137 1645549 Negative_regulation CLU WNT4 17634137 1645550 Negative_regulation CLU WNT6 17634137 1645551 Negative_regulation CMIP CCL17 23971044 183235 Negative_regulation CNR1 MAP2K6 22362764 1201310 Negative_regulation CNTF NES 25206670 2005528 Negative_regulation COA1 FAS 16969344 428135 Negative_regulation COA1 FAS 16969344 428141 Negative_regulation COA1 FAS 18410446 450673 Negative_regulation COA1 FAS 18509489 3072362 Negative_regulation COA1 FAS 23145054 2715515 Negative_regulation COA1 FOXO1 23532271 453326 Negative_regulation COA3 FAS 16969344 428137 Negative_regulation COA3 FAS 16969344 428150 Negative_regulation COA3 FAS 18410446 450675 Negative_regulation COA3 FAS 18509489 3072364 Negative_regulation COA3 FAS 23145054 2715517 Negative_regulation COA3 FOXO1 23532271 453328 Negative_regulation COA4 FAS 16969344 428136 Negative_regulation COA4 FAS 16969344 428148 Negative_regulation COA4 FAS 18410446 450674 Negative_regulation COA4 FAS 18509489 3072363 Negative_regulation COA4 FAS 23145054 2715516 Negative_regulation COA4 FOXO1 23532271 453327 Negative_regulation COA5 FAS 16969344 428138 Negative_regulation COA5 FAS 16969344 428152 Negative_regulation COA5 FAS 18410446 450676 Negative_regulation COA5 FAS 18509489 3072365 Negative_regulation COA5 FAS 23145054 2715518 Negative_regulation COA5 FOXO1 23532271 453329 Negative_regulation COA6 FAS 16969344 428134 Negative_regulation COA6 FAS 16969344 428139 Negative_regulation COA6 FAS 18410446 450672 Negative_regulation COA6 FAS 18509489 3072361 Negative_regulation COA6 FAS 23145054 2715514 Negative_regulation COA6 FOXO1 23532271 453325 Negative_regulation COG2 PCSK9 22998978 1724965 Negative_regulation COG2 PCSK9 23344002 1905707 Negative_regulation COG2 PCSK9 23663650 1726089 Negative_regulation COG2 PCSK9 24319689 185644 Negative_regulation COL17A1 AIRE 23781320 787390 Negative_regulation COL17A1 HDAC1 9660880 1468393 Negative_regulation COL17A1 PLEC 9660880 1468394 Negative_regulation COL1A1 CHI3L1 24281168 501797 Negative_regulation COL1A1 EPHB2 16774692 106033 Negative_regulation COL1A1 HBEGF 22330337 1717962 Negative_regulation COL1A1 TNF 1646205 1327765 Negative_regulation COL1A2 CHI3L1 24281168 501798 Negative_regulation COL1A2 CTGF 24088954 1709554 Negative_regulation COL1A2 EPHB2 16774692 106034 Negative_regulation COL1A2 TNF 1646205 1327766 Negative_regulation COL1A2 TNF 24088954 1709551 Negative_regulation COL2A1 CTGF 23951098 2833417 Negative_regulation COL2A1 MAP2K6 22289259 124739 Negative_regulation COL2A1 TNF 15642133 102072 Negative_regulation COL2A1 TNF 15642133 102086 Negative_regulation COL2A1 TNF 18182117 109789 Negative_regulation COL2A1 TNF 22455954 125284 Negative_regulation COL2A1 TNF 24458429 691975 Negative_regulation COL2A1 WNT7A 24479426 131668 Negative_regulation COL4A1 FOXO1 24145170 1411721 Negative_regulation COL4A2 FOXO1 24145170 1411722 Negative_regulation COL4A3 FOXO1 24145170 1411723 Negative_regulation COL4A4 FOXO1 24145170 1411724 Negative_regulation COL4A5 FOXO1 24145170 1411725 Negative_regulation COL4A6 FOXO1 24145170 1411726 Negative_regulation COPS5 S100A7 20955608 585862 Negative_regulation CPA4 PTGS2 24281339 2245136 Negative_regulation CPB1 ARSA 25506240 1078365 Negative_regulation CPB2 TCN1 19416536 227043 Negative_regulation CPE FOXO1 19767734 1960802 Negative_regulation CPE TNF 25126542 196649 Negative_regulation CPM LBP 7536794 1590171 Negative_regulation CPOX ARSA 20228931 1037741 Negative_regulation CPOX ARSA 22873782 1724885 Negative_regulation CPOX ARSA 23306703 835020 Negative_regulation CPOX ARSA 25238071 3008354 Negative_regulation CPOX ARSA PMC4036660 2246435 Negative_regulation CPOX TNF 19098937 6826 Negative_regulation CPOX TNF 23035900 1231288 Negative_regulation CPP MMP28 25157203 1605637 Negative_regulation CPP MMP7 25157203 1605652 Negative_regulation CPP PLAU 25258509 743267 Negative_regulation CPT1A FOXO1 22533991 264558 Negative_regulation CPT1B PGC 19435887 1165970 Negative_regulation CPT2 TNF 24646507 652064 Negative_regulation CRAT CCND1 10953010 1262077 Negative_regulation CRAT ID1 8045940 1444362 Negative_regulation CRAT TMEM100 10508860 1250985 Negative_regulation CRAT TMEM156 10508860 1251003 Negative_regulation CRAT TMEM211 10508860 1251083 Negative_regulation CRAT TMEM213 10508860 1251020 Negative_regulation CRAT TNF 18475533 1744272 Negative_regulation CREB1 CAPN8 23847533 858554 Negative_regulation CREB1 CCND1 23880895 606212 Negative_regulation CREB1 EPHB2 18036509 153744 Negative_regulation CREB1 EPHB2 19523204 1897233 Negative_regulation CREB1 FAS 22676303 1724575 Negative_regulation CREB1 GLP1R 21744074 733467 Negative_regulation CREB1 PTGER2 25327961 216529 Negative_regulation CREB1 PTGER2 25327961 216566 Negative_regulation CREB1 RASD1 21915321 2553254 Negative_regulation CREB1 RASD1 21915321 2553264 Negative_regulation CREB1 UCA1 24648007 2171562 Negative_regulation CREB3 CAPN8 23847533 858568 Negative_regulation CREB3 CCND1 23880895 606213 Negative_regulation CREB3 EPHB2 18036509 153746 Negative_regulation CREB3 EPHB2 19523204 1897234 Negative_regulation CREB3 FAS 22676303 1724576 Negative_regulation CREB3 GLP1R 21744074 733468 Negative_regulation CREB3 PTGER2 25327961 216567 Negative_regulation CREB3 RASD1 21915321 2553255 Negative_regulation CREB3 RASD1 21915321 2553265 Negative_regulation CREB3 UCA1 24648007 2171563 Negative_regulation CREB3L2 SOX9 24711445 1209112 Negative_regulation CREB5 CAPN8 23847533 858540 Negative_regulation CREB5 CCND1 23880895 606210 Negative_regulation CREB5 EPHB2 18036509 153742 Negative_regulation CREB5 EPHB2 19523204 1897232 Negative_regulation CREB5 FAS 22676303 1724572 Negative_regulation CREB5 GLP1R 21744074 733466 Negative_regulation CREB5 PTGER2 25327961 216564 Negative_regulation CREB5 RASD1 21915321 2553253 Negative_regulation CREB5 RASD1 21915321 2553263 Negative_regulation CREB5 UCA1 24648007 2171561 Negative_regulation CRH NES 19455148 1900382 Negative_regulation CRK CD14 20011115 3045834 Negative_regulation CRK EPHB2 22447027 1956926 Negative_regulation CRK EPHB2 22566886 899587 Negative_regulation CRK EPHB2 23898332 908492 Negative_regulation CRK EPHB2 24340098 2894999 Negative_regulation CRK EPHB2 24348728 824735 Negative_regulation CRK EPHB2 25165721 198115 Negative_regulation CRK EPHB2 PMC3760629 1606100 Negative_regulation CRK MAP2K6 22415879 721924 Negative_regulation CRK MAP2K6 24340098 2895005 Negative_regulation CRK MAP2K6 25165721 198122 Negative_regulation CRK TLR7 22091401 1831056 Negative_regulation CRK TNF 17342245 810708 Negative_regulation CRP CCND1 22367141 1735314 Negative_regulation CRP TNF 21244650 3099721 Negative_regulation CRP TNF 23847549 961626 Negative_regulation CRS AXIN2 23936395 2830255 Negative_regulation CRTC1 PPBP 22983004 541930 Negative_regulation CRTC1 SLC6A2 20947565 2057620 Negative_regulation CS TNF 22039445 2565447 Negative_regulation CSE SRGN 22046339 2566497 Negative_regulation CSE SRGN 24058553 2847957 Negative_regulation CSE SRGN 24058553 2847963 Negative_regulation CSE SRGN 24303182 2251597 Negative_regulation CSE SRGN 25050128 826478 Negative_regulation CSE SRGN 25404917 966647 Negative_regulation CSE SRGN 25415381 3029277 Negative_regulation CSF1 ABCG2 25295160 3208141 Negative_regulation CSF1 NEDD9 23180782 2082310 Negative_regulation CSF1 TNF 1375270 1528746 Negative_regulation CSF2 EPHB2 15743527 1036090 Negative_regulation CSF2 F2R 21464892 2510280 Negative_regulation CSF2 HBEGF 20946648 1859851 Negative_regulation CSF2 HBEGF 20946648 1859878 Negative_regulation CSF2 TLR7 25071732 927113 Negative_regulation CSF2 TNF 1375270 1528774 Negative_regulation CSF2 TNF 21485745 734858 Negative_regulation CSF2 TNF 22963460 1698828 Negative_regulation CSF3 ANGPT1 23036162 660339 Negative_regulation CSF3 ANGPT1 23036162 660341 Negative_regulation CSF3 ANGPT1 23171759 660382 Negative_regulation CSF3 CD14 1708813 1543154 Negative_regulation CSF3 TNF 1375270 1528749 Negative_regulation CSF3 TNF 1375270 1528775 Negative_regulation CSF3 TNF 25382983 1078362 Negative_regulation CSK TNF 19966777 1960915 Negative_regulation CSN2 CTGF 20497571 285136 Negative_regulation CSN3 CTGF 20497571 285132 Negative_regulation CSRP1 TNF 21686173 1091037 Negative_regulation CSRP1 TNF 25136585 197228 Negative_regulation CSRP2 EDN2 24674138 540028 Negative_regulation CST6 CFTR 15279681 315139 Negative_regulation CST6 CTSB 24357805 570676 Negative_regulation CST6 HDAC1 19503093 2125514 Negative_regulation CST6 HDAC1 19503093 2125521 Negative_regulation CST6 HDAC1 19503093 2125533 Negative_regulation CST6 HDAC10 19503093 2125512 Negative_regulation CST6 HDAC11 19503093 2125513 Negative_regulation CST6 HDAC2 19503093 2125515 Negative_regulation CST6 HDAC2 19503093 2125522 Negative_regulation CST6 HDAC2 19503093 2125534 Negative_regulation CST6 HDAC3 19503093 2125516 Negative_regulation CST6 HDAC4 19503093 2125507 Negative_regulation CST6 HDAC5 19503093 2125511 Negative_regulation CST6 HDAC6 19503093 2125508 Negative_regulation CST6 HDAC7 19503093 2125510 Negative_regulation CST6 HDAC8 19503093 2125506 Negative_regulation CST6 HDAC9 19503093 2125509 Negative_regulation CST6 MIF 18958170 2370246 Negative_regulation CST6 RBBP4 19503093 2125523 Negative_regulation CST6 RBBP4 19503093 2125535 Negative_regulation CST6 RBBP7 19503093 2125524 Negative_regulation CST6 RBBP7 19503093 2125536 Negative_regulation CST6 TBX2 24742492 2188904 Negative_regulation CST6 TBX2 24742492 2188907 Negative_regulation CST6 TBX2 24742492 2188914 Negative_regulation CST6 TIMP1 15642138 102342 Negative_regulation CTD PGC 20704745 801844 Negative_regulation CTGF ADM 19597528 7911 Negative_regulation CTGF AGTR2 24459483 746206 Negative_regulation CTGF AHSA1 19852794 1227770 Negative_regulation CTGF AKT1 19152120 1478364 Negative_regulation CTGF AKT1 19390991 1478573 Negative_regulation CTGF AKT2 19152120 1478365 Negative_regulation CTGF AKT2 19390991 1478574 Negative_regulation CTGF AKT3 19152120 1478366 Negative_regulation CTGF AKT3 19390991 1478575 Negative_regulation CTGF ANGPT2 21829546 2541666 Negative_regulation CTGF BMP1 21673687 436934 Negative_regulation CTGF BMP10 21673687 436942 Negative_regulation CTGF BMP15 21673687 436935 Negative_regulation CTGF BMP2 21673687 436936 Negative_regulation CTGF BMP3 21673687 436937 Negative_regulation CTGF BMP4 15466481 1312495 Negative_regulation CTGF BMP4 21673687 436938 Negative_regulation CTGF BMP5 21673687 436939 Negative_regulation CTGF BMP6 21673687 436940 Negative_regulation CTGF BMP7 21673687 436941 Negative_regulation CTGF CAGE1 20697347 2133482 Negative_regulation CTGF CAV1 22751431 541576 Negative_regulation CTGF CAV1 22751431 541578 Negative_regulation CTGF CAV1 25237397 856991 Negative_regulation CTGF CCL4 25310107 3014993 Negative_regulation CTGF CD109 22694813 126320 Negative_regulation CTGF CD109 22694813 126349 Negative_regulation CTGF CDA 24843491 1493355 Negative_regulation CTGF CFD 24415895 1916533 Negative_regulation CTGF CFD 24415895 1916560 Negative_regulation CTGF CFD 24415895 1916562 Negative_regulation CTGF COL1A2 24088954 1709557 Negative_regulation CTGF CXCL12 25121739 2997333 Negative_regulation CTGF ECM1 22586493 2640649 Negative_regulation CTGF ECM2 22586493 2640650 Negative_regulation CTGF EPHB2 17474984 656545 Negative_regulation CTGF EPHB2 25121739 2997350 Negative_regulation CTGF ETS1 16469114 104914 Negative_regulation CTGF ETS1 16469114 104915 Negative_regulation CTGF ETS1 16469114 104928 Negative_regulation CTGF ETS1 22539964 2622640 Negative_regulation CTGF FLI1 16469114 104916 Negative_regulation CTGF FLI1 16469114 104958 Negative_regulation CTGF FLI1 23041765 1086768 Negative_regulation CTGF FLI1 23663495 128402 Negative_regulation CTGF FRMD6 23593160 2779979 Negative_regulation CTGF HDAC1 23281659 856438 Negative_regulation CTGF HDAC2 23281659 856439 Negative_regulation CTGF HSPB1 21559318 804435 Negative_regulation CTGF IGF1 22563064 739559 Negative_regulation CTGF IL1A 19852794 1227669 Negative_regulation CTGF IL1A 20205862 397080 Negative_regulation CTGF ILK 22574216 2636106 Negative_regulation CTGF JUN 22212430 14230 Negative_regulation CTGF JUN 25121739 2997327 Negative_regulation CTGF KLF15 19152120 1478412 Negative_regulation CTGF LSS 21302282 1486055 Negative_regulation CTGF LTBP4 15466481 1312501 Negative_regulation CTGF MAP2K1 23946690 1716104 Negative_regulation CTGF MAPK3 22938209 533078 Negative_regulation CTGF MAPK3 23259759 856342 Negative_regulation CTGF MAPK3 24090133 537556 Negative_regulation CTGF MMP1 23041765 1086769 Negative_regulation CTGF MYLIP 21501375 32626 Negative_regulation CTGF MYLIP 21501375 32652 Negative_regulation CTGF MYLIP 21501375 32653 Negative_regulation CTGF MYLIP 23390502 2750816 Negative_regulation CTGF MYLIP 24212931 548492 Negative_regulation CTGF NOV 24722330 2951153 Negative_regulation CTGF NOV 24722330 2951157 Negative_regulation CTGF PI3 19152120 1478367 Negative_regulation CTGF PIK3CA 19390991 1478576 Negative_regulation CTGF PIK3R1 19390991 1478577 Negative_regulation CTGF PPARA 24678903 856899 Negative_regulation CTGF PPARA 25132338 19395 Negative_regulation CTGF PPARA 25132338 19423 Negative_regulation CTGF PPARA 25132338 19426 Negative_regulation CTGF PTGER2 20205862 397087 Negative_regulation CTGF PTGER2 25327961 216531 Negative_regulation CTGF PTGER2 25327961 216532 Negative_regulation CTGF PTGER2 25327961 216568 Negative_regulation CTGF PTGER4 20205862 397088 Negative_regulation CTGF PTX3 18274641 1741527 Negative_regulation CTGF PTX4 18274641 1741526 Negative_regulation CTGF RAC1 25121739 2997351 Negative_regulation CTGF RBBP4 23281659 856440 Negative_regulation CTGF RBBP7 23281659 856441 Negative_regulation CTGF RHO 23259677 856275 Negative_regulation CTGF RHO 24678903 856902 Negative_regulation CTGF ROCK1 23259677 856276 Negative_regulation CTGF ROCK1 24678903 856903 Negative_regulation CTGF ROCK2 23259677 856277 Negative_regulation CTGF ROCK2 24678903 856904 Negative_regulation CTGF SDC2 19214781 1478508 Negative_regulation CTGF SERPINA3 20299474 713172 Negative_regulation CTGF SERPINA3 20299474 713254 Negative_regulation CTGF SERPINA3 20299474 713255 Negative_regulation CTGF SERPINA3 20299474 713274 Negative_regulation CTGF SERPINE1 24762191 3114561 Negative_regulation CTGF SETD2 24040163 2846037 Negative_regulation CTGF SIL1 17042939 319214 Negative_regulation CTGF SMAD1 24090133 537667 Negative_regulation CTGF SMAD1 24090133 537716 Negative_regulation CTGF SMAD2 21152444 2487035 Negative_regulation CTGF SMAD2 21626291 616659 Negative_regulation CTGF SMAD2 23383241 2749612 Negative_regulation CTGF SMAD2 24090133 537668 Negative_regulation CTGF SMAD3 24090133 537669 Negative_regulation CTGF SMAD4 24090133 537670 Negative_regulation CTGF SMAD5 24090133 537671 Negative_regulation CTGF SMAD6 24090133 537672 Negative_regulation CTGF SMAD7 21152444 2487036 Negative_regulation CTGF SMAD7 24090133 537673 Negative_regulation CTGF SMAD9 24090133 537674 Negative_regulation CTGF SPAG11B 25327961 216608 Negative_regulation CTGF SRF 22563064 739553 Negative_regulation CTGF SRF 22563064 739558 Negative_regulation CTGF TAZ 25354978 1887230 Negative_regulation CTGF TAZ 25354978 1887231 Negative_regulation CTGF TAZ 25354978 1887240 Negative_regulation CTGF TGFB1 17333105 732690 Negative_regulation CTGF TGFB1 22675458 2648567 Negative_regulation CTGF TGFBR1 20507556 855044 Negative_regulation CTGF TGFBR1 23441194 2757014 Negative_regulation CTGF TGFBR3 22694813 126346 Negative_regulation CTGF TIMP1 23344030 1101048 Negative_regulation CTGF TIMP1 23755313 2371952 Negative_regulation CTGF TIMP1 24058760 1705026 Negative_regulation CTGF TIMP4 23755313 2371953 Negative_regulation CTGF TNF 19922639 117861 Negative_regulation CTGF TNF 19922639 117865 Negative_regulation CTGF TNF 19922639 117869 Negative_regulation CTGF TNF 19922639 117877 Negative_regulation CTGF VEGFA 24932681 2980388 Negative_regulation CTGF WNT1 20299474 713160 Negative_regulation CTGF WNT1 20299474 713161 Negative_regulation CTGF WNT11 20299474 713162 Negative_regulation CTGF WNT11 20299474 713163 Negative_regulation CTGF WNT16 20299474 713173 Negative_regulation CTGF WNT16 20299474 713174 Negative_regulation CTGF WNT2 20299474 713164 Negative_regulation CTGF WNT2 20299474 713165 Negative_regulation CTGF WNT3 20299474 713166 Negative_regulation CTGF WNT3 20299474 713167 Negative_regulation CTGF WNT4 20299474 713168 Negative_regulation CTGF WNT4 20299474 713169 Negative_regulation CTGF WNT6 20299474 713170 Negative_regulation CTGF WNT6 20299474 713171 Negative_regulation CTH SRGN 19718041 1931087 Negative_regulation CTNNAL1 LEF1 22359570 2597666 Negative_regulation CTNNAL1 TFAP2A 22359570 2597665 Negative_regulation CTNNB1 AXIN2 10507776 415483 Negative_regulation CTNNB1 AXIN2 24931005 2192481 Negative_regulation CTNNB1 TNFSF10 20661477 2456791 Negative_regulation CTR9 F2R PMC2756345 495993 Negative_regulation CTR9 LPCAT1 25415055 177536 Negative_regulation CTR9 TNF 18472926 1743189 Negative_regulation CTR9 TNF 3119758 1580174 Negative_regulation CTSB CAPN8 22898871 557445 Negative_regulation CTSB CAPN8 23074646 3131363 Negative_regulation CTSB CAPN8 9566966 1467376 Negative_regulation CTSB CST6 19503093 2125517 Negative_regulation CTSB CST6 19503093 2125529 Negative_regulation CTSB CST6 24357805 570678 Negative_regulation CTSB EPHB2 25375375 578927 Negative_regulation CTSB EPHB2 25375375 578930 Negative_regulation CTSB MMP28 21092330 481759 Negative_regulation CTSB MMP7 21092330 481774 Negative_regulation CTSC PLAT 25090090 2994826 Negative_regulation CTSD MAP2K6 24727858 2951744 Negative_regulation CTSG PLAT 20804552 1626135 Negative_regulation CTSH CST6 24996653 1502718 Negative_regulation CTSL CLU 21949677 2556149 Negative_regulation CTSL PLAU 8382511 444874 Negative_regulation CTSS EPHB2 25375375 578931 Negative_regulation CTSS ID1 19956687 2432393 Negative_regulation CUL1 CCND1 17407548 1846331 Negative_regulation CUL1 MAP2K6 25401222 2207199 Negative_regulation CX3CL1 TNF 22566871 899056 Negative_regulation CX3CL1 TNF 22566871 899065 Negative_regulation CXCL1 S1PR3 21887342 2549379 Negative_regulation CXCL10 TNF 18046562 1072325 Negative_regulation CXCL10 TNF 22022590 2563982 Negative_regulation CXCL10 TNF 23717673 2798736 Negative_regulation CXCL11 EPHB2 24586980 2928489 Negative_regulation CXCL11 EPHB2 24586980 2928490 Negative_regulation CXCL12 ANGPT1 22558265 2624901 Negative_regulation CXCL12 ANGPT1 22558265 2624918 Negative_regulation CXCL12 F2R 24834915 2970969 Negative_regulation CXCL12 NR2F1 24906407 273677 Negative_regulation CXCL12 S1PR3 19002266 2400305 Negative_regulation CXCL12 TNF 18371213 110340 Negative_regulation CXCL12 TNF 18371213 110341 Negative_regulation CXCL12 TNF 18371213 110342 Negative_regulation CXCL12 TNF 18371213 110343 Negative_regulation CXCL12 TNF 18371213 110350 Negative_regulation CXCL12 TNF 18371213 110354 Negative_regulation CXCL12 TNF 18371213 110358 Negative_regulation CXCL12 TNF 18371213 110362 Negative_regulation CXCL12 TNF 19484126 2417823 Negative_regulation CXCL12 TNF 22675496 2648969 Negative_regulation CXCL13 ANO1 22973054 1807579 Negative_regulation CXCL13 ANO1 22973054 1807580 Negative_regulation CXCL2 CHI3L1 24399973 963262 Negative_regulation CXCL2 IL1B 24618842 2933377 Negative_regulation CXCL9 TNF 11696601 1521794 Negative_regulation CXCR1 TNF 22152684 124439 Negative_regulation CXCR1 TNF 22152684 124441 Negative_regulation CXCR1 TNF 22152684 124448 Negative_regulation CXCR2 TNF 22152684 124440 Negative_regulation CXCR2 TNF 22152684 124443 Negative_regulation CXCR2 TNF 22152684 124449 Negative_regulation CXCR2 TNF 22745844 2371429 Negative_regulation CXCR4 ANGPT1 22558265 2624904 Negative_regulation CXCR4 ANGPT1 22558265 2624910 Negative_regulation CXCR4 EPHB2 21909361 2550678 Negative_regulation CXCR4 EPHB2 25514788 3034628 Negative_regulation CXCR4 EPHB2 25514788 3034629 Negative_regulation CXCR4 EPHB2 25514788 3034639 Negative_regulation CXCR4 EPHB2 25514788 3034657 Negative_regulation CXCR4 EPHB2 25514788 3034664 Negative_regulation CXCR4 EPHB2 25514788 3034667 Negative_regulation CXCR4 EPHB2 25514788 3034674 Negative_regulation CXCR4 EPHB2 25514788 3034686 Negative_regulation CXCR4 EPHB2 25514788 3034687 Negative_regulation CXCR4 EPHB2 25514788 3034700 Negative_regulation CXCR4 TNF 20699000 257072 Negative_regulation CXCR4 TNF 21508508 736862 Negative_regulation CXCR4 TNF 22723782 958061 Negative_regulation CYBA TNF 23983473 3209317 Negative_regulation CYBB TNF 23983473 3209319 Negative_regulation CYCS CAPN8 21886605 928088 Negative_regulation CYCS CAPN8 22056617 13632 Negative_regulation CYCS FAS 19654878 2422791 Negative_regulation CYCS LGALS7B 21289092 1786163 Negative_regulation CYCS MAP2K6 24096434 93514 Negative_regulation CYCS MMP28 21991395 2561760 Negative_regulation CYCS MMP28 22447225 14611 Negative_regulation CYCS MMP28 24256980 295272 Negative_regulation CYCS MMP28 25505905 23352 Negative_regulation CYCS MMP7 21991395 2561775 Negative_regulation CYCS MMP7 22447225 14626 Negative_regulation CYCS MMP7 24256980 295287 Negative_regulation CYCS MMP7 25505905 23369 Negative_regulation CYCS PGC 19435887 1165955 Negative_regulation CYCS TGM2 20665636 774902 Negative_regulation CYLD EPHB2 19124656 1553497 Negative_regulation CYLD PDE4B 23575688 1935962 Negative_regulation CYLD PDE4B 23575688 1935963 Negative_regulation CYLD PDE4B 23575688 1935976 Negative_regulation CYLD TNF 24098568 2858180 Negative_regulation CYP11B2 F2R 20204133 1213966 Negative_regulation CYP19A1 CCND1 24848372 2972403 Negative_regulation CYP1A1 MAP2K6 22111840 1864194 Negative_regulation CYP1A1 TNF 19835593 2232836 Negative_regulation CYP1A2 TNF 19835593 2232820 Negative_regulation CYP24A1 CYP27B1 24175086 647948 Negative_regulation CYP24A1 ESR1 23405058 2751389 Negative_regulation CYP24A1 HPD 21738762 2533692 Negative_regulation CYP24A1 PTH 24175086 647949 Negative_regulation CYP24A1 VDR 21179018 1903864 Negative_regulation CYP24A1 VDR 22084796 1154720 Negative_regulation CYP24A1 YY1 23700364 983775 Negative_regulation CYP24A1 YY1 23700364 983787 Negative_regulation CYP27B1 CYP24A1 24175086 647950 Negative_regulation CYP2E1 MAP2K6 25343014 3180575 Negative_regulation CYP7A1 TNF 16277680 104665 Negative_regulation CYP7A1 TNF 16277680 104666 Negative_regulation CYSLTR1 ALOX5 PMC4033953 2245793 Negative_regulation DANCR C12orf75 19531736 2046593 Negative_regulation DAPK1 C4BPA 22314197 834277 Negative_regulation DAPK1 CANX 21219631 258379 Negative_regulation DAPK1 DAPK2 23114086 625145 Negative_regulation DAPK1 EPHB2 24710474 618130 Negative_regulation DAPK1 HDAC1 22160140 2170605 Negative_regulation DAPK1 HDAC10 22160140 2170603 Negative_regulation DAPK1 HDAC11 22160140 2170604 Negative_regulation DAPK1 HDAC2 22160140 2170606 Negative_regulation DAPK1 HDAC3 22160140 2170607 Negative_regulation DAPK1 HDAC4 22160140 2170598 Negative_regulation DAPK1 HDAC5 22160140 2170602 Negative_regulation DAPK1 HDAC6 22160140 2170599 Negative_regulation DAPK1 HDAC7 22160140 2170601 Negative_regulation DAPK1 HDAC8 22160140 2170597 Negative_regulation DAPK1 HDAC9 22160140 2170600 Negative_regulation DAPK1 PRDX2 22160140 2170608 Negative_regulation DAPK1 RPS6 24710474 618128 Negative_regulation DAPK1 RPS6KA1 21219631 258378 Negative_regulation DAPK1 SRC 23175185 548166 Negative_regulation DAPK1 STK11 24710474 618129 Negative_regulation DAPK2 EPHB2 24710474 618133 Negative_regulation DAPK3 EPHB2 24710474 618136 Negative_regulation DBH MAOA 24116298 204431 Negative_regulation DBH WNT7A 25170755 3003897 Negative_regulation DCN TNF 19087346 3109108 Negative_regulation DCP2 TNF 21569625 1723644 Negative_regulation DCP2 TNF 24086143 2350894 Negative_regulation DDIT3 EGLN3 21085474 2482435 Negative_regulation DDIT3 FOXO1 24475223 2915271 Negative_regulation DDIT3 TLR7 20513765 1376520 Negative_regulation DDIT3 TLR7 22231169 1928174 Negative_regulation DDIT3 TLR7 22454627 832532 Negative_regulation DDX20 SMN2 21339974 1090497 Negative_regulation DDX20 SMN2 24210254 2008327 Negative_regulation DEFA1B RNASE1 12756231 1292643 Negative_regulation DEFA1B RNASE7 12756231 1292651 Negative_regulation DEFA1B TNF 20525314 119113 Negative_regulation DEFB4B CD14 23046822 1698886 Negative_regulation DFFB CLU 25180771 3004341 Negative_regulation DFFB FOXQ1 22761930 2659243 Negative_regulation DGCR14 F2R 23940457 2283785 Negative_regulation DHDDS MMP28 22303396 882177 Negative_regulation DHDDS MMP7 22303396 882192 Negative_regulation DHFR FOLR1 22403528 929901 Negative_regulation DHFR MSX1 24276168 2244561 Negative_regulation DHX58 TLR7 22185352 3214661 Negative_regulation DIABLO LGALS7B 21289092 1786164 Negative_regulation DIABLO MAP2K6 23056924 140490 Negative_regulation DIANPH GLP1R 23621921 381308 Negative_regulation DIANPH GLP1R 23621921 381311 Negative_regulation DIANPH SPON2 22235198 832499 Negative_regulation DICER1 RNASE1 21552258 1976195 Negative_regulation DICER1 RNASE1 21552258 1976231 Negative_regulation DICER1 RNASE7 21552258 1976204 Negative_regulation DICER1 RNASE7 21552258 1976240 Negative_regulation DIO1 SYNM 19138393 2112422 Negative_regulation DIO1 TNF 20808947 2473076 Negative_regulation DIO2 TNF 20808947 2473077 Negative_regulation DIO3 TNF 20808947 2473078 Negative_regulation DISC1 FAS 24204853 2874451 Negative_regulation DISC1 MUC16 24690311 272527 Negative_regulation DISC1 TNFSF10 23470529 560758 Negative_regulation DISC2 FAS 24204853 2874453 Negative_regulation DISC2 MUC16 24690311 272528 Negative_regulation DISC2 TNFSF10 23470529 560759 Negative_regulation DKC1 STAT4 21738677 2533230 Negative_regulation DKC1 TNF 21485744 734856 Negative_regulation DKC1 ZFP57 25032857 577202 Negative_regulation DKC1 ZFP57 25032857 577203 Negative_regulation DKC1 ZFP57 25032857 577331 Negative_regulation DKK1 CLU 23164821 1901010 Negative_regulation DKK1 RCAN1 21546446 1885496 Negative_regulation DKK1 TNF 24250816 2881716 Negative_regulation DKK1 TNF 24250816 2881728 Negative_regulation DKK1 TNF 25228904 914174 Negative_regulation DKK3 ANGPT1 23765731 3080558 Negative_regulation DLL1 JAG1 18665263 2394133 Negative_regulation DLL1 JAG1 19161597 302037 Negative_regulation DLL1 JAG1 22390640 124849 Negative_regulation DLL1 JAG1 22390640 124850 Negative_regulation DLL1 MAP2K6 21418646 305013 Negative_regulation DLL4 JAG1 22487493 3207565 Negative_regulation DLL4 JAG1 23967210 2834848 Negative_regulation DLX2 MSX1 16157866 2017599 Negative_regulation DMD CAPN8 24232452 1121539 Negative_regulation DMD PDE5A 24391598 963242 Negative_regulation DMD TNF 20814569 2473443 Negative_regulation DNAJC5 TNF 23806004 294426 Negative_regulation DNASE1 RNASE1 17212830 319295 Negative_regulation DNASE1 RNASE1 17704135 2028964 Negative_regulation DNASE1 RNASE1 18405378 365354 Negative_regulation DNASE1 RNASE1 20421948 3046654 Negative_regulation DNASE1 RNASE1 21804562 1921517 Negative_regulation DNASE1 RNASE1 22163032 2577859 Negative_regulation DNASE1 RNASE1 24714342 3141468 Negative_regulation DNASE1 RNASE1 24956304 1606550 Negative_regulation DNASE1 RNASE1 9271581 1601443 Negative_regulation DNASE1 RNASE7 17212830 319303 Negative_regulation DNASE1 RNASE7 17704135 2028972 Negative_regulation DNASE1 RNASE7 18405378 365362 Negative_regulation DNASE1 RNASE7 20421948 3046662 Negative_regulation DNASE1 RNASE7 21804562 1921525 Negative_regulation DNASE1 RNASE7 22163032 2577867 Negative_regulation DNASE1 RNASE7 24714342 3141476 Negative_regulation DNASE1 RNASE7 24956304 1606558 Negative_regulation DNASE1 RNASE7 9271581 1601451 Negative_regulation DNASE2 RNASE1 21804562 1921529 Negative_regulation DNASE2 RNASE1 9271581 1601455 Negative_regulation DNASE2 RNASE7 21804562 1921537 Negative_regulation DNASE2 RNASE7 9271581 1601463 Negative_regulation DNM1 CAPN8 17047312 1212384 Negative_regulation DNMT1 EPHB2 21941583 633229 Negative_regulation DNMT1 TNFSF10 21108789 1860317 Negative_regulation DNMT1 WNT7A 22403725 2609244 Negative_regulation DNMT3A EPHB2 24282625 2887144 Negative_regulation DOK5 MAP2K6 24551065 2922981 Negative_regulation DPP4 GLP1R 20412332 1072309 Negative_regulation DPP4 GLP1R 23818527 727635 Negative_regulation DPP4 GLP1R 25071725 880972 Negative_regulation DRD2 KLF9 22375010 1201493 Negative_regulation DUSP1 EPHB2 21547253 1749055 Negative_regulation DUSP1 EPHB2 25100999 954773 Negative_regulation DUSP6 EPHB2 19476641 1897202 Negative_regulation DYRK1B EPHB2 23311607 482666 Negative_regulation DYRK1B EPHB2 23311607 482687 Negative_regulation DYRK1B EPHB2 23311607 482688 Negative_regulation DYRK1B MAP2K6 23311607 482684 Negative_regulation DYRK1B MAP2K6 23311607 482694 Negative_regulation DYRK1B MAP2K6 23311607 482721 Negative_regulation E2F1 EPHB2 23902294 344722 Negative_regulation E2F1 IFI27 21566658 547250 Negative_regulation E2F1 IFI27 21566658 547258 Negative_regulation E2F1 UCA1 24876127 758397 Negative_regulation EBF1 ZFP57 21539723 3168882 Negative_regulation EBF1 ZFP57 23209378 2281044 Negative_regulation EBF1 ZFP57 23209378 2281080 Negative_regulation EBF1 ZFP57 23569325 1571325 Negative_regulation ECD JAG1 22509166 957018 Negative_regulation ECM1 CD14 19710907 2424816 Negative_regulation ECM1 CD14 23133375 3059955 Negative_regulation ECM1 CTGF 17224075 279448 Negative_regulation ECM1 CTGF 22511849 1914258 Negative_regulation ECM1 CTGF 22586493 2640652 Negative_regulation ECM1 CTGF 23750089 163595 Negative_regulation ECM1 CTGF 23946690 1716126 Negative_regulation ECM1 CTGF 23946690 1716127 Negative_regulation ECM1 CTGF 23950936 2832983 Negative_regulation ECM1 CTGF 23950936 2832995 Negative_regulation ECM1 CTGF 25057273 826498 Negative_regulation ECM1 MMP28 24070030 388694 Negative_regulation ECM1 MMP7 24070030 388709 Negative_regulation ECM1 PLAU 22131991 1673219 Negative_regulation ECM1 PLAU 23145071 2715584 Negative_regulation ECM1 TLR7 18612394 2392653 Negative_regulation ECM1 TNF 21189948 1713907 Negative_regulation ECM2 CD14 19710907 2424817 Negative_regulation ECM2 CD14 23133375 3059956 Negative_regulation ECM2 CTGF 17224075 279449 Negative_regulation ECM2 CTGF 22511849 1914259 Negative_regulation ECM2 CTGF 22586493 2640653 Negative_regulation ECM2 CTGF 23750089 163596 Negative_regulation ECM2 CTGF 23946690 1716128 Negative_regulation ECM2 CTGF 23946690 1716129 Negative_regulation ECM2 CTGF 23950936 2832984 Negative_regulation ECM2 CTGF 23950936 2832996 Negative_regulation ECM2 CTGF 25057273 826499 Negative_regulation ECM2 MMP28 24070030 388716 Negative_regulation ECM2 MMP7 24070030 388731 Negative_regulation ECM2 PLAU 22131991 1673221 Negative_regulation ECM2 PLAU 23145071 2715585 Negative_regulation ECM2 TLR7 18612394 2392663 Negative_regulation ECM2 TNF 21189948 1713911 Negative_regulation EDIL3 TNF 24416060 639487 Negative_regulation EDN1 EDN2 21461356 1674810 Negative_regulation EDN1 EPHB2 23139420 1205634 Negative_regulation EDN1 EPHB2 9679149 1468902 Negative_regulation EDN1 GPNMB 23884103 220659 Negative_regulation EDN1 TNF 23565184 2777065 Negative_regulation EDN1 TNF 24040253 2846237 Negative_regulation EDN2 ADM 21034462 3099610 Negative_regulation EDN2 ADRBK1 20705669 513714 Negative_regulation EDN2 CDC42 22128240 1913132 Negative_regulation EDN2 ECE1 24040226 2846200 Negative_regulation EDN2 EDN3 24040226 2846201 Negative_regulation EDN2 GAPDH 24282406 969851 Negative_regulation EDN2 MAPK3 18778461 274654 Negative_regulation EDN2 MME 21951628 805467 Negative_regulation EDN2 NPPA 25202235 932241 Negative_regulation EDN2 SETD2 22874467 834878 Negative_regulation EDNRB FHL1 24516350 1085057 Negative_regulation EEF1A2 SPHK1 25264785 3010749 Negative_regulation EFNB1 FAS 22545146 2623989 Negative_regulation EFNB1 FGFR1 19047466 1362054 Negative_regulation EFNB1 IFIT2 20565770 360376 Negative_regulation EFNB1 MYLIP 22232059 3171881 Negative_regulation EFNB1 PIK3CA 22879882 2672837 Negative_regulation EFNB1 PIK3R1 22879882 2672838 Negative_regulation EFNB1 PROX1 22232059 3171871 Negative_regulation EFNB1 PTPN13 22279592 2590837 Negative_regulation EFNB1 PTPN13 22279592 2590838 Negative_regulation EFNB1 SRC 22279592 2590854 Negative_regulation EFNB1 TNF 24098442 2856359 Negative_regulation EFNB1 TNF 24098442 2856362 Negative_regulation EFNB1 TNF 24098442 2856366 Negative_regulation EFNB1 TNF 24098442 2856368 Negative_regulation EFNB1 TNF 24098442 2856372 Negative_regulation EFNB1 TNF 24098442 2856378 Negative_regulation EFNB2 EFNB1 22403721 2609224 Negative_regulation EFNB2 FAS 22545146 2623990 Negative_regulation EFNB3 FAS 22545146 2623991 Negative_regulation EGF EPHB2 21258408 2137636 Negative_regulation EGF EPHB2 21364986 2504748 Negative_regulation EGF EPHB2 22675459 2648708 Negative_regulation EGF EPHB2 23083134 1867201 Negative_regulation EGF EPHB2 23752269 1905010 Negative_regulation EGF MAP2K6 16207364 996563 Negative_regulation EGF MAP2K6 23083134 1867207 Negative_regulation EGF RGS16 25568667 987486 Negative_regulation EGF RGS16 25568667 987492 Negative_regulation EGF SPHK1 16636149 1329357 Negative_regulation EGF TNF 21034435 3099593 Negative_regulation EGFR ABCG2 21731744 2532356 Negative_regulation EGFR BPI 21218173 549336 Negative_regulation EGFR CTGF 23175185 548178 Negative_regulation EGFR EPHB2 20195469 2441825 Negative_regulation EGFR EPHB2 21333004 404416 Negative_regulation EGFR EPHB2 22070864 291834 Negative_regulation EGFR EPHB2 23155381 2716922 Negative_regulation EGFR EPHB2 23342981 1030138 Negative_regulation EGFR EPHB2 23829771 410459 Negative_regulation EGFR EPHB2 24172289 314623 Negative_regulation EGFR HBEGF 22747893 1664301 Negative_regulation EGFR HBEGF 24013225 2153507 Negative_regulation EGFR HBEGF 25421240 1135179 Negative_regulation EGFR ID1 15599381 425173 Negative_regulation EGFR IL1B 23977375 2840134 Negative_regulation EGFR MAP2K6 21333004 404422 Negative_regulation EGFR MAP2K6 23143667 2172093 Negative_regulation EGFR MUC16 23408941 2752913 Negative_regulation EGFR S100A7 18320059 2384878 Negative_regulation EGFR S1PR3 16636149 1329279 Negative_regulation EGFR SPHK1 16636149 1329250 Negative_regulation EGFR SPHK1 16636149 1329320 Negative_regulation EGFR SPHK1 16636149 1329346 Negative_regulation EGFR SPHK1 16636149 1329359 Negative_regulation EGLN1 ANGPT1 18835934 707025 Negative_regulation EGLN1 ANGPT1 18835934 707042 Negative_regulation EGLN1 ANGPT1 23616286 780646 Negative_regulation EGLN1 ANGPT1 23737442 780959 Negative_regulation EGLN3 HIF1AN 20967267 2478623 Negative_regulation EGLN3 PAGR1 24755992 2957407 Negative_regulation EGLN3 PDC 24132642 2008998 Negative_regulation EGLN3 PPIE 20677832 156750 Negative_regulation EGLN3 SERPINB5 25578879 1879296 Negative_regulation EGLN3 SLC22A3 24367580 2900246 Negative_regulation EGLN3 VHL 21791076 1862879 Negative_regulation EGLN3 ZEB1 24367580 2900250 Negative_regulation EGR1 CTGF 23946690 1716123 Negative_regulation EGR1 EPHB2 24069530 750806 Negative_regulation EGR1 MMP28 22792188 2661264 Negative_regulation EGR1 MMP7 22792188 2661280 Negative_regulation EGR2 CCND1 14757751 1305483 Negative_regulation EGR2 CCND1 14757751 1305496 Negative_regulation EIF2A TLR7 22028783 2564304 Negative_regulation EIF2AK2 MAP2K6 21994558 3218445 Negative_regulation EIF2S2 CCND1 22253692 2587601 Negative_regulation EIF4E FOXO1 22476916 1238829 Negative_regulation EIF4E RNASE1 16699599 3039169 Negative_regulation ELANE MMP28 25255451 3010406 Negative_regulation ELANE MMP7 25255451 3010421 Negative_regulation ELAVL1 ITGAL 21206905 2491143 Negative_regulation ELAVL1 ITGAL 21206905 2491196 Negative_regulation ELL CAPN8 19183810 2405165 Negative_regulation ELL ELOVL4 21139992 1912418 Negative_regulation ELL FHL1 18611274 281575 Negative_regulation ELL FOXA1 22238690 2587085 Negative_regulation ELL HBEGF 22446737 1928268 Negative_regulation ELL ITGAL 22711877 1568397 Negative_regulation ELL MAP2K6 24649261 1884435 Negative_regulation ELL SRGN 20032306 1772590 Negative_regulation ELL TMOD1 12975349 1297050 Negative_regulation ELL TMOD1 12975349 1297084 Negative_regulation ELL TMOD1 20737540 694956 Negative_regulation ELL TMOD1 24866031 989403 Negative_regulation ELL TMOD1 7730404 1439778 Negative_regulation ELL TMOD1 7798317 1441657 Negative_regulation ELL TMOD1 7798317 1441685 Negative_regulation ELL TMOD1 7798317 1441706 Negative_regulation ELL TMOD1 7798317 1441730 Negative_regulation ELL TMOD1 7798317 1441770 Negative_regulation EMP1 EDIL3 24770423 2958523 Negative_regulation ENDOU CD22 24344237 1574237 Negative_regulation ENG CEACAM6 24735478 540369 Negative_regulation ENG PECAM1 8655583 1451939 Negative_regulation ENPP1 ENTPD1 24744886 2251751 Negative_regulation ENPP1 ENTPD2 24744886 2251752 Negative_regulation ENTPD1 ENPP1 24744886 2251762 Negative_regulation ENTPD2 ENPP1 24744886 2251769 Negative_regulation EPAS1 TNFSF10 24255707 2882010 Negative_regulation EPC1 ANGPT1 16189517 426350 Negative_regulation EPC1 EPHB2 25268972 3011845 Negative_regulation EPC1 ID1 18092003 2381434 Negative_regulation EPC1 ID1 23714001 1699829 Negative_regulation EPC1 ID1 24620998 132057 Negative_regulation EPC2 ANGPT1 16189517 426351 Negative_regulation EPC2 EPHB2 25268972 3011849 Negative_regulation EPC2 ID1 18092003 2381435 Negative_regulation EPC2 ID1 23714001 1699830 Negative_regulation EPC2 ID1 24620998 132058 Negative_regulation EPHA3 IFI27 18422703 608047 Negative_regulation EPHA3 TLR7 23469297 2371766 Negative_regulation EPHA8 RINL 22291991 2591648 Negative_regulation EPHB2 ABCC6 21935379 2555369 Negative_regulation EPHB2 ABI3 21223585 258398 Negative_regulation EPHB2 ACAD8 23424281 2281864 Negative_regulation EPHB2 ACD 23360994 1934900 Negative_regulation EPHB2 ACE 24330074 1482213 Negative_regulation EPHB2 ACE 25221602 1071119 Negative_regulation EPHB2 ACE 25310253 2118994 Negative_regulation EPHB2 ACE2 22693641 2651326 Negative_regulation EPHB2 ACO2 21887333 2549332 Negative_regulation EPHB2 ACR 23230390 1243156 Negative_regulation EPHB2 ACR 24103747 269994 Negative_regulation EPHB2 ACR 24103747 270010 Negative_regulation EPHB2 ACR 24103747 270011 Negative_regulation EPHB2 ACTL6A 24811485 2190637 Negative_regulation EPHB2 ACTL6A 24811485 2190934 Negative_regulation EPHB2 ADAM17 25013379 1063090 Negative_regulation EPHB2 ADCYAP1 23967296 2835521 Negative_regulation EPHB2 ADCYAP1 24098484 2856603 Negative_regulation EPHB2 ADI1 23933651 18442 Negative_regulation EPHB2 ADIPOQ 23935932 2828495 Negative_regulation EPHB2 ADIPOQ 23935932 2828496 Negative_regulation EPHB2 ADRBK1 23977191 2838872 Negative_regulation EPHB2 ADRBK1 23977191 2838876 Negative_regulation EPHB2 AGTR1 20814573 2473476 Negative_regulation EPHB2 AHR 24527405 135998 Negative_regulation EPHB2 AHSA1 15699069 1534506 Negative_regulation EPHB2 AHSA1 20107538 1037457 Negative_regulation EPHB2 AHSA1 20727231 466207 Negative_regulation EPHB2 AHSA1 21739608 776468 Negative_regulation EPHB2 AHSA1 22605923 1914325 Negative_regulation EPHB2 AHSA1 22769588 521322 Negative_regulation EPHB2 AHSA1 22860116 2671702 Negative_regulation EPHB2 AHSA1 23060802 959412 Negative_regulation EPHB2 AHSA1 23901045 1065534 Negative_regulation EPHB2 AHSA1 23991110 2840953 Negative_regulation EPHB2 AHSA1 24406729 1122928 Negative_regulation EPHB2 AHSA1 25155142 1917709 Negative_regulation EPHB2 AHSA1 25299270 174403 Negative_regulation EPHB2 AHSA1 25398056 3027486 Negative_regulation EPHB2 AKT1 12799645 422687 Negative_regulation EPHB2 AKT1 16365168 1326382 Negative_regulation EPHB2 AKT1 16365168 1326383 Negative_regulation EPHB2 AKT1 16365168 1326384 Negative_regulation EPHB2 AKT1 16365168 1326385 Negative_regulation EPHB2 AKT1 16365168 1326386 Negative_regulation EPHB2 AKT1 16365168 1326421 Negative_regulation EPHB2 AKT1 16365168 1326426 Negative_regulation EPHB2 AKT1 16365168 1326427 Negative_regulation EPHB2 AKT1 16365168 1326437 Negative_regulation EPHB2 AKT1 20042122 1852836 Negative_regulation EPHB2 AKT1 20195469 2441829 Negative_regulation EPHB2 AKT1 21278786 2137714 Negative_regulation EPHB2 AKT1 22293957 1086459 Negative_regulation EPHB2 AKT1 22384148 2606705 Negative_regulation EPHB2 AKT1 22403613 2608997 Negative_regulation EPHB2 AKT1 22403613 2609009 Negative_regulation EPHB2 AKT1 22477519 1238994 Negative_regulation EPHB2 AKT1 22668349 212845 Negative_regulation EPHB2 AKT1 22753894 1398729 Negative_regulation EPHB2 AKT1 23049696 2699101 Negative_regulation EPHB2 AKT1 23076254 605012 Negative_regulation EPHB2 AKT1 23133361 2297650 Negative_regulation EPHB2 AKT1 23549166 543153 Negative_regulation EPHB2 AKT1 24155779 1240241 Negative_regulation EPHB2 AKT1 24416349 2907927 Negative_regulation EPHB2 AKT1 24499258 34937 Negative_regulation EPHB2 AKT1 24533454 271659 Negative_regulation EPHB2 AKT1 24551245 2923428 Negative_regulation EPHB2 AKT1 24611016 2122733 Negative_regulation EPHB2 AKT1 25421240 1135052 Negative_regulation EPHB2 AKT1 25431423 741605 Negative_regulation EPHB2 AKT1 25431423 741613 Negative_regulation EPHB2 AKT1 25530619 1136252 Negative_regulation EPHB2 AKT1S1 23437362 2756626 Negative_regulation EPHB2 AKT2 12799645 422688 Negative_regulation EPHB2 AKT2 16365168 1326422 Negative_regulation EPHB2 AKT2 16365168 1326428 Negative_regulation EPHB2 AKT2 16365168 1326429 Negative_regulation EPHB2 AKT2 20042122 1852837 Negative_regulation EPHB2 AKT2 20195469 2441830 Negative_regulation EPHB2 AKT2 21278786 2137715 Negative_regulation EPHB2 AKT2 22293957 1086460 Negative_regulation EPHB2 AKT2 22384148 2606706 Negative_regulation EPHB2 AKT2 22403613 2608998 Negative_regulation EPHB2 AKT2 22403613 2609010 Negative_regulation EPHB2 AKT2 22477519 1238995 Negative_regulation EPHB2 AKT2 22668349 212846 Negative_regulation EPHB2 AKT2 22753894 1398730 Negative_regulation EPHB2 AKT2 23049696 2699102 Negative_regulation EPHB2 AKT2 23076254 605013 Negative_regulation EPHB2 AKT2 23133361 2297651 Negative_regulation EPHB2 AKT2 23549166 543154 Negative_regulation EPHB2 AKT2 24155779 1240242 Negative_regulation EPHB2 AKT2 24416349 2907928 Negative_regulation EPHB2 AKT2 24499258 34938 Negative_regulation EPHB2 AKT2 24533454 271660 Negative_regulation EPHB2 AKT2 24551245 2923429 Negative_regulation EPHB2 AKT2 24611016 2122734 Negative_regulation EPHB2 AKT2 25421240 1135053 Negative_regulation EPHB2 AKT2 25431423 741606 Negative_regulation EPHB2 AKT2 25431423 741614 Negative_regulation EPHB2 AKT2 25530619 1136253 Negative_regulation EPHB2 AKT3 12799645 422689 Negative_regulation EPHB2 AKT3 16365168 1326430 Negative_regulation EPHB2 AKT3 20042122 1852838 Negative_regulation EPHB2 AKT3 20195469 2441831 Negative_regulation EPHB2 AKT3 21278786 2137716 Negative_regulation EPHB2 AKT3 22293957 1086461 Negative_regulation EPHB2 AKT3 22384148 2606707 Negative_regulation EPHB2 AKT3 22403613 2608999 Negative_regulation EPHB2 AKT3 22403613 2609011 Negative_regulation EPHB2 AKT3 22477519 1238996 Negative_regulation EPHB2 AKT3 22668349 212847 Negative_regulation EPHB2 AKT3 22753894 1398731 Negative_regulation EPHB2 AKT3 23049696 2699103 Negative_regulation EPHB2 AKT3 23076254 605014 Negative_regulation EPHB2 AKT3 23133361 2297652 Negative_regulation EPHB2 AKT3 23549166 543155 Negative_regulation EPHB2 AKT3 24155779 1240243 Negative_regulation EPHB2 AKT3 24416349 2907929 Negative_regulation EPHB2 AKT3 24499258 34939 Negative_regulation EPHB2 AKT3 24533454 271661 Negative_regulation EPHB2 AKT3 24551245 2923430 Negative_regulation EPHB2 AKT3 24611016 2122735 Negative_regulation EPHB2 AKT3 25421240 1135054 Negative_regulation EPHB2 AKT3 25431423 741607 Negative_regulation EPHB2 AKT3 25431423 741615 Negative_regulation EPHB2 AKT3 25530619 1136254 Negative_regulation EPHB2 AKTIP 25593982 2172172 Negative_regulation EPHB2 AKTIP 25593982 2172173 Negative_regulation EPHB2 ALK 21799923 2539209 Negative_regulation EPHB2 ALPI 10525543 1251428 Negative_regulation EPHB2 ALPI 10525543 1251434 Negative_regulation EPHB2 ALPI 10525543 1251435 Negative_regulation EPHB2 ANGPT1 17341311 279565 Negative_regulation EPHB2 ANGPT1 23250359 725428 Negative_regulation EPHB2 ANGPT1 25009501 965404 Negative_regulation EPHB2 ANGPT2 17341311 279566 Negative_regulation EPHB2 ANGPT2 24358274 2899172 Negative_regulation EPHB2 ANO1 24639373 492647 Negative_regulation EPHB2 ANO6 24663380 2938046 Negative_regulation EPHB2 ANO6 24663380 2938047 Negative_regulation EPHB2 ANXA1 21635771 3084201 Negative_regulation EPHB2 ANXA6 23599172 2183031 Negative_regulation EPHB2 ANXA6 23599172 2183032 Negative_regulation EPHB2 ANXA6 25431423 741608 Negative_regulation EPHB2 ANXA6 25431423 741616 Negative_regulation EPHB2 APC 20403177 659536 Negative_regulation EPHB2 APC 20403177 659537 Negative_regulation EPHB2 APC 20403177 659546 Negative_regulation EPHB2 APC 20403177 659561 Negative_regulation EPHB2 APC 20403177 659562 Negative_regulation EPHB2 APC 23451122 2758042 Negative_regulation EPHB2 APH1B 19247475 2406536 Negative_regulation EPHB2 APH1B 19247475 2406548 Negative_regulation EPHB2 APOA1 20102334 651181 Negative_regulation EPHB2 ARC 24045785 3137109 Negative_regulation EPHB2 ARHGAP8 23155002 1809641 Negative_regulation EPHB2 ARID1A 24811485 2190636 Negative_regulation EPHB2 ARID1A 24811485 2190933 Negative_regulation EPHB2 ATG4B 24240988 1939523 Negative_regulation EPHB2 ATG4B 24240988 1939539 Negative_regulation EPHB2 ATG7 24240988 1939521 Negative_regulation EPHB2 ATL1 21831303 1659184 Negative_regulation EPHB2 ATL1 21831303 1659301 Negative_regulation EPHB2 ATL2 21831303 1659185 Negative_regulation EPHB2 ATL2 21831303 1659302 Negative_regulation EPHB2 ATL3 21831303 1659186 Negative_regulation EPHB2 ATL3 21831303 1659303 Negative_regulation EPHB2 ATM 18312689 1003641 Negative_regulation EPHB2 ATRX 21547158 3177183 Negative_regulation EPHB2 BANF1 22046349 2566516 Negative_regulation EPHB2 BANF1 22046349 2566722 Negative_regulation EPHB2 BANF1 22046349 2566770 Negative_regulation EPHB2 BANF1 23589723 818571 Negative_regulation EPHB2 BANP 17668048 2377273 Negative_regulation EPHB2 BCL10 22396737 2608347 Negative_regulation EPHB2 BCL2 23363601 1811553 Negative_regulation EPHB2 BCL2 23363601 1811561 Negative_regulation EPHB2 BCL2 23392177 559846 Negative_regulation EPHB2 BDKRB2 18036509 153703 Negative_regulation EPHB2 BDNF 17908330 384348 Negative_regulation EPHB2 BDNF 17908330 384350 Negative_regulation EPHB2 BDNF 19390590 2414848 Negative_regulation EPHB2 BDNF 20840753 1897670 Negative_regulation EPHB2 BDNF 22022520 2563532 Negative_regulation EPHB2 BDNF 23346360 3133970 Negative_regulation EPHB2 BDNF 23700454 2796231 Negative_regulation EPHB2 BDNF 23776632 2805339 Negative_regulation EPHB2 BDNF 24204683 2873273 Negative_regulation EPHB2 BECN1 23392177 559844 Negative_regulation EPHB2 BMP1 22547091 603338 Negative_regulation EPHB2 BMP10 22547091 603346 Negative_regulation EPHB2 BMP15 22547091 603339 Negative_regulation EPHB2 BMP2 22547091 603340 Negative_regulation EPHB2 BMP3 22547091 603341 Negative_regulation EPHB2 BMP4 22547091 603342 Negative_regulation EPHB2 BMP5 22547091 603343 Negative_regulation EPHB2 BMP6 22547091 603344 Negative_regulation EPHB2 BMP7 22124112 1566319 Negative_regulation EPHB2 BMP7 22547091 603345 Negative_regulation EPHB2 BMX 24312323 2888503 Negative_regulation EPHB2 BMX 24312323 2888520 Negative_regulation EPHB2 BPIFA1 19949542 672214 Negative_regulation EPHB2 BPIFA1 23472073 2763833 Negative_regulation EPHB2 BRAF 19804630 401969 Negative_regulation EPHB2 BRAF 20149136 2252476 Negative_regulation EPHB2 BRAF 21505228 2175848 Negative_regulation EPHB2 BRAF 21505228 2175911 Negative_regulation EPHB2 BRAF 22113612 1988014 Negative_regulation EPHB2 BRAF 23085539 2181368 Negative_regulation EPHB2 BRAF 23626542 514891 Negative_regulation EPHB2 BRAF 23658559 883839 Negative_regulation EPHB2 BRAF 23907581 3136582 Negative_regulation EPHB2 BRAF 25275294 2202560 Negative_regulation EPHB2 BRAF 25538140 1905526 Negative_regulation EPHB2 BSG 22870202 2672039 Negative_regulation EPHB2 BSG 25268615 1131320 Negative_regulation EPHB2 BTK 24693884 484333 Negative_regulation EPHB2 C1QA 20977756 379589 Negative_regulation EPHB2 C1QB 20977756 379590 Negative_regulation EPHB2 C4A 24789665 1886420 Negative_regulation EPHB2 CA2 11914123 276513 Negative_regulation EPHB2 CA2 12370087 225129 Negative_regulation EPHB2 CA2 24223965 2877504 Negative_regulation EPHB2 CA2 24687958 1575551 Negative_regulation EPHB2 CA2 25121483 2997209 Negative_regulation EPHB2 CA2 25324743 861299 Negative_regulation EPHB2 CA2 25420019 3029476 Negative_regulation EPHB2 CALM3 20071468 1772991 Negative_regulation EPHB2 CALM3 25093823 2995354 Negative_regulation EPHB2 CAMKK1 20802521 2135562 Negative_regulation EPHB2 CAMKK2 20802521 2135563 Negative_regulation EPHB2 CAMKK2 20802521 2135615 Negative_regulation EPHB2 CAMP 23549262 1104534 Negative_regulation EPHB2 CASP1 23685957 17653 Negative_regulation EPHB2 CASP10 23685957 17654 Negative_regulation EPHB2 CASP12 23685957 17664 Negative_regulation EPHB2 CASP14 23685957 17655 Negative_regulation EPHB2 CASP16 23685957 17665 Negative_regulation EPHB2 CASP2 23685957 17656 Negative_regulation EPHB2 CASP3 21936896 1659747 Negative_regulation EPHB2 CASP3 23685957 17657 Negative_regulation EPHB2 CASP3 24586814 2927113 Negative_regulation EPHB2 CASP4 23685957 17658 Negative_regulation EPHB2 CASP5 23685957 17659 Negative_regulation EPHB2 CASP6 23685957 17660 Negative_regulation EPHB2 CASP7 23685957 17661 Negative_regulation EPHB2 CASP8 23685957 17662 Negative_regulation EPHB2 CASP9 23685957 17663 Negative_regulation EPHB2 CAV1 21826216 2540884 Negative_regulation EPHB2 CAV1 22802909 2219343 Negative_regulation EPHB2 CAV1 24011378 3114059 Negative_regulation EPHB2 CAV1 24011378 3114060 Negative_regulation EPHB2 CAV1 24011378 3114119 Negative_regulation EPHB2 CAV1 24744103 494738 Negative_regulation EPHB2 CBL 24351824 1122122 Negative_regulation EPHB2 CBL 24351824 1122126 Negative_regulation EPHB2 CBR1 19476641 1897203 Negative_regulation EPHB2 CBR1 19476641 1897204 Negative_regulation EPHB2 CBR1 19476641 1897221 Negative_regulation EPHB2 CBR1 19476641 1897225 Negative_regulation EPHB2 CBR1 19476641 1897226 Negative_regulation EPHB2 CCL1 25222785 1045941 Negative_regulation EPHB2 CCL2 24789665 1886418 Negative_regulation EPHB2 CCL2 24826069 1917001 Negative_regulation EPHB2 CCL2 24826069 1917006 Negative_regulation EPHB2 CCL2 24826069 1917027 Negative_regulation EPHB2 CCL20 24979261 2985618 Negative_regulation EPHB2 CCNA2 25187756 484813 Negative_regulation EPHB2 CCND1 16879721 1163601 Negative_regulation EPHB2 CCND1 19015320 1361429 Negative_regulation EPHB2 CCND1 22833568 1806154 Negative_regulation EPHB2 CCR5 22506069 2618366 Negative_regulation EPHB2 CCR6 24979261 2985619 Negative_regulation EPHB2 CCR6 24979261 2985637 Negative_regulation EPHB2 CCT 25500121 479771 Negative_regulation EPHB2 CD151 20581856 10217 Negative_regulation EPHB2 CD151 20581856 10218 Negative_regulation EPHB2 CD160 18377664 1897037 Negative_regulation EPHB2 CD209 18282094 3040987 Negative_regulation EPHB2 CD4 23742646 3121880 Negative_regulation EPHB2 CD44 22870202 2672040 Negative_regulation EPHB2 CD44 25268615 1131321 Negative_regulation EPHB2 CDC42 21455314 2510241 Negative_regulation EPHB2 CDH1 19015320 1361430 Negative_regulation EPHB2 CDH1 24318272 2186005 Negative_regulation EPHB2 CDH1 25375090 2206992 Negative_regulation EPHB2 CDK5 17156427 279408 Negative_regulation EPHB2 CDKN1A 16351709 1844971 Negative_regulation EPHB2 CDKN1A 16879721 1163603 Negative_regulation EPHB2 CDKN1A 23155423 2717215 Negative_regulation EPHB2 CDKN1A 25309914 201077 Negative_regulation EPHB2 CDKN1A 9864370 1473424 Negative_regulation EPHB2 CDKN1B 19665013 698149 Negative_regulation EPHB2 CDKN1B 24563807 1242093 Negative_regulation EPHB2 CFP 23667670 2791209 Negative_regulation EPHB2 CHKA 21772273 1933148 Negative_regulation EPHB2 CHKA 21772273 1933171 Negative_regulation EPHB2 CHKA 21772273 1933180 Negative_regulation EPHB2 CHUK 23752269 1905011 Negative_regulation EPHB2 CLDN2 22767581 1805468 Negative_regulation EPHB2 CNP 17374144 299803 Negative_regulation EPHB2 CNP 25352084 1887200 Negative_regulation EPHB2 CNR1 21559295 2518072 Negative_regulation EPHB2 CNR1 23864865 3174120 Negative_regulation EPHB2 CNR1 25395834 743434 Negative_regulation EPHB2 CNTN2 25175936 493091 Negative_regulation EPHB2 CPOX 21294864 121402 Negative_regulation EPHB2 CREB1 18036509 153748 Negative_regulation EPHB2 CREB3 18036509 153749 Negative_regulation EPHB2 CREB5 18036509 153747 Negative_regulation EPHB2 CRK 20107538 1037455 Negative_regulation EPHB2 CRK 21738464 2294594 Negative_regulation EPHB2 CRK 22447027 1956929 Negative_regulation EPHB2 CRK 24340098 2895047 Negative_regulation EPHB2 CRK 24348728 824737 Negative_regulation EPHB2 CRK 25165721 198146 Negative_regulation EPHB2 CRK PMC3760629 1606130 Negative_regulation EPHB2 CSF1 23752925 611262 Negative_regulation EPHB2 CSF2 19426550 282376 Negative_regulation EPHB2 CSF2 23752925 611263 Negative_regulation EPHB2 CSK 24317039 1959506 Negative_regulation EPHB2 CSNK1A1 22303459 2594554 Negative_regulation EPHB2 CTGF 23175185 548187 Negative_regulation EPHB2 CTGF 23227240 2725725 Negative_regulation EPHB2 CTLA4 19783989 1953236 Negative_regulation EPHB2 CTLA4 23586039 181081 Negative_regulation EPHB2 CTSA 22103431 651466 Negative_regulation EPHB2 CUL1 23709168 96674 Negative_regulation EPHB2 CXCL10 25222785 1045942 Negative_regulation EPHB2 CXCL12 22319600 2595591 Negative_regulation EPHB2 CXCL12 23382784 3177268 Negative_regulation EPHB2 CXCL12 24598933 2931704 Negative_regulation EPHB2 CXCR2 23029099 2695238 Negative_regulation EPHB2 CXCR4 23133664 2713663 Negative_regulation EPHB2 CXCR4 23961808 483837 Negative_regulation EPHB2 CXCR4 25514788 3034689 Negative_regulation EPHB2 CYLD 17548520 1546295 Negative_regulation EPHB2 CYLD 17548520 1546303 Negative_regulation EPHB2 CYLD 25389768 3025152 Negative_regulation EPHB2 CYLD 25389768 3025153 Negative_regulation EPHB2 DAG1 20163697 526491 Negative_regulation EPHB2 DIAPH3 22593025 778657 Negative_regulation EPHB2 DLG4 23424281 2281819 Negative_regulation EPHB2 DLX4 20551949 434990 Negative_regulation EPHB2 DOK1 15611294 1534058 Negative_regulation EPHB2 DOK1 15699069 1534456 Negative_regulation EPHB2 DOK1 15699069 1534494 Negative_regulation EPHB2 DOK2 15611294 1534059 Negative_regulation EPHB2 DOK2 15699069 1534457 Negative_regulation EPHB2 DOK2 15699069 1534495 Negative_regulation EPHB2 DOK2 24255704 2881788 Negative_regulation EPHB2 DOK3 22761938 2659354 Negative_regulation EPHB2 DOK3 22761938 2659393 Negative_regulation EPHB2 DPP4 24755682 2957247 Negative_regulation EPHB2 DST 22470480 2614303 Negative_regulation EPHB2 DST 22991565 1498096 Negative_regulation EPHB2 DUSP1 19333377 2408916 Negative_regulation EPHB2 DUSP1 20953200 1961203 Negative_regulation EPHB2 DUSP1 23060802 959352 Negative_regulation EPHB2 DUSP1 23271975 2340618 Negative_regulation EPHB2 DUSP1 23823128 2808698 Negative_regulation EPHB2 DUSP1 24098442 2856375 Negative_regulation EPHB2 DUSP1 25100999 954775 Negative_regulation EPHB2 DUSP10 23271975 2340619 Negative_regulation EPHB2 DUSP11 23271975 2340620 Negative_regulation EPHB2 DUSP12 23271975 2340621 Negative_regulation EPHB2 DUSP13 23271975 2340613 Negative_regulation EPHB2 DUSP14 23271975 2340609 Negative_regulation EPHB2 DUSP15 23271975 2340608 Negative_regulation EPHB2 DUSP16 23271975 2340610 Negative_regulation EPHB2 DUSP18 23271975 2340611 Negative_regulation EPHB2 DUSP19 23271975 2340612 Negative_regulation EPHB2 DUSP2 23271975 2340622 Negative_regulation EPHB2 DUSP21 23271975 2340614 Negative_regulation EPHB2 DUSP22 23271975 2340607 Negative_regulation EPHB2 DUSP23 23271975 2340615 Negative_regulation EPHB2 DUSP26 23271975 2340617 Negative_regulation EPHB2 DUSP27 23271975 2340616 Negative_regulation EPHB2 DUSP28 23271975 2340630 Negative_regulation EPHB2 DUSP3 23271975 2340623 Negative_regulation EPHB2 DUSP4 23271975 2340624 Negative_regulation EPHB2 DUSP4 24658355 2188359 Negative_regulation EPHB2 DUSP5 19333377 2408917 Negative_regulation EPHB2 DUSP5 23271975 2340625 Negative_regulation EPHB2 DUSP5 24651368 2936458 Negative_regulation EPHB2 DUSP6 16012519 426300 Negative_regulation EPHB2 DUSP6 19476641 1897205 Negative_regulation EPHB2 DUSP6 19636436 1671446 Negative_regulation EPHB2 DUSP6 21165163 2174646 Negative_regulation EPHB2 DUSP6 21610072 1191758 Negative_regulation EPHB2 DUSP6 21698133 2324879 Negative_regulation EPHB2 DUSP6 21949697 2556386 Negative_regulation EPHB2 DUSP6 21998560 2294752 Negative_regulation EPHB2 DUSP6 23271975 2340626 Negative_regulation EPHB2 DUSP6 24099000 367272 Negative_regulation EPHB2 DUSP6 24260056 2166336 Negative_regulation EPHB2 DUSP6 24952610 1702186 Negative_regulation EPHB2 DUSP7 23271975 2340627 Negative_regulation EPHB2 DUSP8 23271975 2340628 Negative_regulation EPHB2 DUSP8 24099000 367273 Negative_regulation EPHB2 DUSP9 23271975 2340629 Negative_regulation EPHB2 DYNLL1 21461354 2001887 Negative_regulation EPHB2 EDN1 23139420 1205647 Negative_regulation EPHB2 EDN1 9679149 1468903 Negative_regulation EPHB2 EFNA1 22022520 2563548 Negative_regulation EPHB2 EFNA2 22022520 2563549 Negative_regulation EPHB2 EFNA3 22022520 2563550 Negative_regulation EPHB2 EFNA4 22022520 2563551 Negative_regulation EPHB2 EFNA5 22022520 2563533 Negative_regulation EPHB2 EFNA5 22022520 2563552 Negative_regulation EPHB2 EFNA5 22022520 2563554 Negative_regulation EPHB2 EFNA5 22022520 2563606 Negative_regulation EPHB2 EFNA5 22022520 2563616 Negative_regulation EPHB2 EFNA5 22022520 2563617 Negative_regulation EPHB2 EFNB2 12925710 1296087 Negative_regulation EPHB2 EGF 18158318 1548140 Negative_regulation EPHB2 EGF 18335055 2387152 Negative_regulation EPHB2 EGF 18662397 1242943 Negative_regulation EPHB2 EGF 19428336 153779 Negative_regulation EPHB2 EGF 21364986 2504749 Negative_regulation EPHB2 EGF 21829671 2542272 Negative_regulation EPHB2 EGF 22777356 2147978 Negative_regulation EPHB2 EGF 23162692 3131658 Negative_regulation EPHB2 EGF 24155779 1240240 Negative_regulation EPHB2 EGF 24155779 1240263 Negative_regulation EPHB2 EGF 24916153 399792 Negative_regulation EPHB2 EGF 25246767 743244 Negative_regulation EPHB2 EGF 25421240 1135051 Negative_regulation EPHB2 EGFL7 24647208 2936062 Negative_regulation EPHB2 EGFR 19804630 401964 Negative_regulation EPHB2 EGFR 21333004 404424 Negative_regulation EPHB2 EGFR 21461392 1052471 Negative_regulation EPHB2 EGFR 21961726 261096 Negative_regulation EPHB2 EGFR 22248929 2177365 Negative_regulation EPHB2 EGFR 22675028 1803709 Negative_regulation EPHB2 EGFR 22747893 1664268 Negative_regulation EPHB2 EGFR 22904641 490782 Negative_regulation EPHB2 EGFR 22984397 2688313 Negative_regulation EPHB2 EGFR 22984397 2688315 Negative_regulation EPHB2 EGFR 23009336 1866972 Negative_regulation EPHB2 EGFR 23155381 2716923 Negative_regulation EPHB2 EGFR 23272129 2729625 Negative_regulation EPHB2 EGFR 23342981 1030139 Negative_regulation EPHB2 EGFR 23907581 3136580 Negative_regulation EPHB2 EGFR 25364708 861531 Negative_regulation EPHB2 EGFR 25421240 1135128 Negative_regulation EPHB2 EMD 25393427 3026220 Negative_regulation EPHB2 EPHA1 19144211 463433 Negative_regulation EPHB2 EPHA1 22022520 2563609 Negative_regulation EPHB2 EPHA10 19144211 463432 Negative_regulation EPHB2 EPHA10 22022520 2563608 Negative_regulation EPHB2 EPHA2 18797457 431210 Negative_regulation EPHB2 EPHA2 19144211 463434 Negative_regulation EPHB2 EPHA2 22022520 2563610 Negative_regulation EPHB2 EPHA2 22916121 2680024 Negative_regulation EPHB2 EPHA3 19144211 463435 Negative_regulation EPHB2 EPHA3 22022520 2563611 Negative_regulation EPHB2 EPHA3 22144690 1394367 Negative_regulation EPHB2 EPHA4 19144211 463436 Negative_regulation EPHB2 EPHA4 22022520 2563612 Negative_regulation EPHB2 EPHA5 19144211 463437 Negative_regulation EPHB2 EPHA5 22022520 2563613 Negative_regulation EPHB2 EPHA6 19144211 463431 Negative_regulation EPHB2 EPHA6 22022520 2563607 Negative_regulation EPHB2 EPHA7 19144211 463438 Negative_regulation EPHB2 EPHA7 22022520 2563614 Negative_regulation EPHB2 EPHA8 19144211 463439 Negative_regulation EPHB2 EPHA8 22022520 2563615 Negative_regulation EPHB2 EPHB1 12925710 1296010 Negative_regulation EPHB2 EPHB4 25247423 2288175 Negative_regulation EPHB2 EPOR 23028796 2693070 Negative_regulation EPHB2 EPX 21415991 1764454 Negative_regulation EPHB2 ERAS 23907581 3136581 Negative_regulation EPHB2 ERBB2 10648571 1255589 Negative_regulation EPHB2 ERBB2 10648571 1255627 Negative_regulation EPHB2 ERBB2 10648571 1255629 Negative_regulation EPHB2 ERBB2 15210733 1310154 Negative_regulation EPHB2 ERBB2 19855434 2127729 Negative_regulation EPHB2 ERBB2 22777356 2148013 Negative_regulation EPHB2 ERBB2 24152442 1120659 Negative_regulation EPHB2 ERBB2 24374844 1681150 Negative_regulation EPHB2 ERF 21505453 436719 Negative_regulation EPHB2 ETS1 25203554 3006415 Negative_regulation EPHB2 ETS1 25294825 2105132 Negative_regulation EPHB2 ETS2 25203554 3006416 Negative_regulation EPHB2 EZR 22132106 2574116 Negative_regulation EPHB2 F2R 20855497 1560232 Negative_regulation EPHB2 FAIM2 24335530 1669171 Negative_regulation EPHB2 FBF1 25414766 206507 Negative_regulation EPHB2 FBLIM1 22843679 1204085 Negative_regulation EPHB2 FGF1 17553162 300186 Negative_regulation EPHB2 FGF1 24823357 1883815 Negative_regulation EPHB2 FGF1 9832563 1472168 Negative_regulation EPHB2 FGF10 17553162 300187 Negative_regulation EPHB2 FGF10 9832563 1472169 Negative_regulation EPHB2 FGF11 17553162 300188 Negative_regulation EPHB2 FGF11 9832563 1472170 Negative_regulation EPHB2 FGF12 17553162 300189 Negative_regulation EPHB2 FGF12 9832563 1472171 Negative_regulation EPHB2 FGF13 17553162 300190 Negative_regulation EPHB2 FGF13 9832563 1472172 Negative_regulation EPHB2 FGF14 17553162 300191 Negative_regulation EPHB2 FGF14 9832563 1472173 Negative_regulation EPHB2 FGF16 17553162 300192 Negative_regulation EPHB2 FGF16 9832563 1472174 Negative_regulation EPHB2 FGF17 17553162 300193 Negative_regulation EPHB2 FGF17 9832563 1472175 Negative_regulation EPHB2 FGF18 17553162 300194 Negative_regulation EPHB2 FGF18 23863940 1990732 Negative_regulation EPHB2 FGF18 9832563 1472176 Negative_regulation EPHB2 FGF19 17553162 300195 Negative_regulation EPHB2 FGF19 9832563 1472177 Negative_regulation EPHB2 FGF2 17553162 300196 Negative_regulation EPHB2 FGF2 23793469 31281 Negative_regulation EPHB2 FGF2 24827991 2969920 Negative_regulation EPHB2 FGF2 9832563 1472178 Negative_regulation EPHB2 FGF20 17553162 300197 Negative_regulation EPHB2 FGF20 9832563 1472179 Negative_regulation EPHB2 FGF21 17553162 300198 Negative_regulation EPHB2 FGF21 9832563 1472180 Negative_regulation EPHB2 FGF22 17553162 300199 Negative_regulation EPHB2 FGF22 9832563 1472181 Negative_regulation EPHB2 FGF23 17553162 300200 Negative_regulation EPHB2 FGF23 9832563 1472182 Negative_regulation EPHB2 FGF3 17553162 300201 Negative_regulation EPHB2 FGF3 9832563 1472183 Negative_regulation EPHB2 FGF4 17553162 300202 Negative_regulation EPHB2 FGF4 9832563 1472184 Negative_regulation EPHB2 FGF5 17553162 300203 Negative_regulation EPHB2 FGF5 9832563 1472185 Negative_regulation EPHB2 FGF6 17553162 300204 Negative_regulation EPHB2 FGF6 9832563 1472186 Negative_regulation EPHB2 FGF7 17553162 300205 Negative_regulation EPHB2 FGF7 9832563 1472187 Negative_regulation EPHB2 FGF8 17553162 300206 Negative_regulation EPHB2 FGF8 9832563 1472188 Negative_regulation EPHB2 FGF9 17553162 300207 Negative_regulation EPHB2 FGF9 9832563 1472189 Negative_regulation EPHB2 FGFR1 19047466 1361923 Negative_regulation EPHB2 FGFR1 19047466 1361924 Negative_regulation EPHB2 FGFR1 19047466 1361925 Negative_regulation EPHB2 FGFR1 19047466 1361926 Negative_regulation EPHB2 FGFR1 19047466 1362055 Negative_regulation EPHB2 FGFR1 24980830 2194849 Negative_regulation EPHB2 FGFR2 19047466 1361927 Negative_regulation EPHB2 FGFR2 19047466 1361928 Negative_regulation EPHB2 FGFR2 19047466 1361929 Negative_regulation EPHB2 FGFR3 19047466 1361930 Negative_regulation EPHB2 FGFR3 19047466 1361931 Negative_regulation EPHB2 FGFR3 19047466 1361932 Negative_regulation EPHB2 FGFR4 19047466 1361933 Negative_regulation EPHB2 FGFR4 19047466 1361934 Negative_regulation EPHB2 FGFR4 19047466 1361935 Negative_regulation EPHB2 FHL2 19925682 327063 Negative_regulation EPHB2 FLT4 24046321 703713 Negative_regulation EPHB2 FLVCR2 25500121 479772 Negative_regulation EPHB2 FLVCR2 25500121 479773 Negative_regulation EPHB2 FN1 9832564 1472231 Negative_regulation EPHB2 FOXO1 22477519 1238992 Negative_regulation EPHB2 FOXO3 22477519 1238993 Negative_regulation EPHB2 FOXO4 22477519 1238998 Negative_regulation EPHB2 FOXO6 22477519 1238991 Negative_regulation EPHB2 FPR1 24192910 1920116 Negative_regulation EPHB2 FPR2 23549262 1104635 Negative_regulation EPHB2 FRS2 22078327 261785 Negative_regulation EPHB2 FRS2 22235335 2585960 Negative_regulation EPHB2 FRS3 22078327 261784 Negative_regulation EPHB2 FST 24568636 1031455 Negative_regulation EPHB2 GAB1 19357636 1902988 Negative_regulation EPHB2 GAB1 21123182 1189552 Negative_regulation EPHB2 GABPA 21270272 717455 Negative_regulation EPHB2 GADD45B 18021443 384471 Negative_regulation EPHB2 GAPDH 21806815 354626 Negative_regulation EPHB2 GAPDH 22964641 2148664 Negative_regulation EPHB2 GAPDH 23139420 1205648 Negative_regulation EPHB2 GATA1 25149543 2198587 Negative_regulation EPHB2 GATA1 25149543 2198596 Negative_regulation EPHB2 GCK 19826475 2428600 Negative_regulation EPHB2 GDF15 24216995 500924 Negative_regulation EPHB2 GHR 24963636 2983414 Negative_regulation EPHB2 GLI1 24384722 570752 Negative_regulation EPHB2 GLI2 17227833 217561 Negative_regulation EPHB2 GLIPR2 23516513 2768184 Negative_regulation EPHB2 GNB2L1 23555900 2775763 Negative_regulation EPHB2 GPC4 24633815 3081939 Negative_regulation EPHB2 GPER1 24763086 2958125 Negative_regulation EPHB2 GPX3 25333265 2205621 Negative_regulation EPHB2 GPX3 25333265 2205628 Negative_regulation EPHB2 GPX3 25333265 2205629 Negative_regulation EPHB2 GRAP2 20107538 1037456 Negative_regulation EPHB2 GRAP2 21048967 2480294 Negative_regulation EPHB2 GRAP2 22605923 1914326 Negative_regulation EPHB2 GRAP2 23060802 959353 Negative_regulation EPHB2 GRAP2 23418602 2754830 Negative_regulation EPHB2 GRAP2 24348728 824738 Negative_regulation EPHB2 GRAP2 25165721 198148 Negative_regulation EPHB2 GRB2 24710474 618139 Negative_regulation EPHB2 GRB2 24775912 1874100 Negative_regulation EPHB2 GRK6 23497290 1867516 Negative_regulation EPHB2 GRK6 23497290 1867549 Negative_regulation EPHB2 GRM5 23489026 451442 Negative_regulation EPHB2 GSTM1 22867088 2233293 Negative_regulation EPHB2 GYS1 20700369 1911809 Negative_regulation EPHB2 GYS2 20700369 1911810 Negative_regulation EPHB2 GZMB 23118219 1205521 Negative_regulation EPHB2 HDAC1 23166712 2718713 Negative_regulation EPHB2 HDAC2 23166712 2718714 Negative_regulation EPHB2 HDAC6 24023871 2843838 Negative_regulation EPHB2 HGF 25383712 3024268 Negative_regulation EPHB2 HNF1B 25079440 1128791 Negative_regulation EPHB2 HPSE 19543297 7541 Negative_regulation EPHB2 HRAS 12516548 2001288 Negative_regulation EPHB2 HRAS 19804630 401923 Negative_regulation EPHB2 HRAS 19804630 401943 Negative_regulation EPHB2 HRAS 19877500 734747 Negative_regulation EPHB2 HRAS 20071468 1772928 Negative_regulation EPHB2 HRAS 20562914 2132657 Negative_regulation EPHB2 HRAS 20802521 2135564 Negative_regulation EPHB2 HRAS 20926686 1783317 Negative_regulation EPHB2 HRAS 21731751 2532406 Negative_regulation EPHB2 HRAS 21731751 2532422 Negative_regulation EPHB2 HRAS 22609986 1928319 Negative_regulation EPHB2 HRAS 22701199 2234540 Negative_regulation EPHB2 HRAS 24216703 500557 Negative_regulation EPHB2 HRAS 25275294 2202379 Negative_regulation EPHB2 HRAS 9314533 1463465 Negative_regulation EPHB2 HRAS 9432981 1602472 Negative_regulation EPHB2 HRG 24551596 947311 Negative_regulation EPHB2 HSP90AA1 23781121 1753379 Negative_regulation EPHB2 HTN3 24495360 1627719 Negative_regulation EPHB2 ICAM1 16430772 3106043 Negative_regulation EPHB2 IFIT2 20565770 360377 Negative_regulation EPHB2 IFNB1 22427889 2610581 Negative_regulation EPHB2 IGF1 21569410 291743 Negative_regulation EPHB2 IGF1 21595894 467789 Negative_regulation EPHB2 IGF1 21871133 1863069 Negative_regulation EPHB2 IGF1 24968248 3068295 Negative_regulation EPHB2 IGF1 24968248 3068314 Negative_regulation EPHB2 IGF1R 21505228 2175870 Negative_regulation EPHB2 IGFBP7 20158915 1504044 Negative_regulation EPHB2 IGFBP7 24201810 568983 Negative_regulation EPHB2 IKBKB 23752269 1905012 Negative_regulation EPHB2 IKBKG 23752269 1905013 Negative_regulation EPHB2 IL10 24260222 2882859 Negative_regulation EPHB2 IL1A 16207331 104234 Negative_regulation EPHB2 IL1A 16207331 104348 Negative_regulation EPHB2 IL1A 23675368 878485 Negative_regulation EPHB2 IL1A 25299270 174404 Negative_regulation EPHB2 IL21 24574581 1757516 Negative_regulation EPHB2 IL21 24574581 1757528 Negative_regulation EPHB2 IL23R 24351840 1122233 Negative_regulation EPHB2 IL6 21122157 1860403 Negative_regulation EPHB2 IL6 21871133 1863070 Negative_regulation EPHB2 IL6 21871133 1863082 Negative_regulation EPHB2 IL6 24789665 1886421 Negative_regulation EPHB2 IL8 23609496 1105971 Negative_regulation EPHB2 INPPL1 25383712 3024269 Negative_regulation EPHB2 INPPL1 25383712 3024282 Negative_regulation EPHB2 INPPL1 25383712 3024431 Negative_regulation EPHB2 INS 21044348 1891787 Negative_regulation EPHB2 INS 21998735 2562274 Negative_regulation EPHB2 INS 22031825 2565210 Negative_regulation EPHB2 INS 22978440 266292 Negative_regulation EPHB2 INS 24491031 1871717 Negative_regulation EPHB2 IRAK3 22761938 2659380 Negative_regulation EPHB2 IRS1 22477519 1238997 Negative_regulation EPHB2 IRS1 22788551 1230795 Negative_regulation EPHB2 ITGAM 23549262 1104674 Negative_regulation EPHB2 ITPKA 22384237 2607523 Negative_regulation EPHB2 JAK1 22567028 634393 Negative_regulation EPHB2 JAK2 22567028 634394 Negative_regulation EPHB2 JAK3 22567028 634395 Negative_regulation EPHB2 JUN 19144997 1991893 Negative_regulation EPHB2 JUN 23243430 816467 Negative_regulation EPHB2 JUN 25203554 3006417 Negative_regulation EPHB2 KCNJ3 21655370 454428 Negative_regulation EPHB2 KCNRG 20237900 3204922 Negative_regulation EPHB2 KDR 22941289 15969 Negative_regulation EPHB2 KIF26A 24466442 1654177 Negative_regulation EPHB2 KIF26A 24466442 1654193 Negative_regulation EPHB2 KITLG 22216034 22194 Negative_regulation EPHB2 KRAS 10471035 415098 Negative_regulation EPHB2 KRAS 19804630 401924 Negative_regulation EPHB2 KRAS 19804630 401944 Negative_regulation EPHB2 KRAS 19877500 734748 Negative_regulation EPHB2 KRAS 20071468 1772929 Negative_regulation EPHB2 KRAS 20562914 2132658 Negative_regulation EPHB2 KRAS 20802521 2135565 Negative_regulation EPHB2 KRAS 20926686 1783318 Negative_regulation EPHB2 KRAS 22701199 2234541 Negative_regulation EPHB2 KRAS 23724131 2799395 Negative_regulation EPHB2 KRAS 24071646 566567 Negative_regulation EPHB2 KRAS 24071646 566600 Negative_regulation EPHB2 KRAS 24348666 3204679 Negative_regulation EPHB2 KRAS 25275294 2202380 Negative_regulation EPHB2 KRAS 9314533 1463466 Negative_regulation EPHB2 KRAS 9432981 1602473 Negative_regulation EPHB2 KSR1 23267331 960623 Negative_regulation EPHB2 KSR2 24209692 517605 Negative_regulation EPHB2 LAMTOR3 22776333 532851 Negative_regulation EPHB2 LBH 24023871 2843839 Negative_regulation EPHB2 LBH 24023871 2843851 Negative_regulation EPHB2 LCK 12810687 1527632 Negative_regulation EPHB2 LCK 22413885 355160 Negative_regulation EPHB2 LIF 24643025 2935540 Negative_regulation EPHB2 LILRB1 24349829 478315 Negative_regulation EPHB2 LIN37 23908058 3227848 Negative_regulation EPHB2 LIN52 23908058 3227845 Negative_regulation EPHB2 LIN54 23908058 3227846 Negative_regulation EPHB2 LIN9 23908058 3227847 Negative_regulation EPHB2 LOX 19597471 2125644 Negative_regulation EPHB2 LOX 22438909 2612016 Negative_regulation EPHB2 LOX 23750284 2801484 Negative_regulation EPHB2 LOX 23750284 2801496 Negative_regulation EPHB2 LRP1 12499359 1290479 Negative_regulation EPHB2 LRP1 20644732 2456128 Negative_regulation EPHB2 LRP1 20644732 2456135 Negative_regulation EPHB2 LRP1 20644732 2456151 Negative_regulation EPHB2 LRPAP1 21368873 550838 Negative_regulation EPHB2 LRPAP1 23318582 610999 Negative_regulation EPHB2 LRPAP1 23318582 611036 Negative_regulation EPHB2 LRPAP1 23318582 611041 Negative_regulation EPHB2 LRPAP1 24349210 2897129 Negative_regulation EPHB2 LRRK2 22666358 2647876 Negative_regulation EPHB2 LUM 24367547 2900203 Negative_regulation EPHB2 LY9 24376606 2901389 Negative_regulation EPHB2 LYN 22731636 1866174 Negative_regulation EPHB2 MALT1 22396737 2608346 Negative_regulation EPHB2 MAP2K1 16351709 1844972 Negative_regulation EPHB2 MAP2K1 18060073 2381313 Negative_regulation EPHB2 MAP2K1 20181064 526503 Negative_regulation EPHB2 MAP2K1 20403177 659547 Negative_regulation EPHB2 MAP2K1 20868520 1859522 Negative_regulation EPHB2 MAP2K1 20886098 3048807 Negative_regulation EPHB2 MAP2K1 21347362 2503681 Negative_regulation EPHB2 MAP2K1 21776388 1686266 Negative_regulation EPHB2 MAP2K1 22564882 2180034 Negative_regulation EPHB2 MAP2K1 22941289 15970 Negative_regulation EPHB2 MAP2K1 24384722 570753 Negative_regulation EPHB2 MAP2K1 24810962 2190472 Negative_regulation EPHB2 MAP2K1 24917786 931956 Negative_regulation EPHB2 MAP2K1 25063862 1502735 Negative_regulation EPHB2 MAP2K1 25068118 3167130 Negative_regulation EPHB2 MAP2K1 25149543 2198597 Negative_regulation EPHB2 MAP2K1 25165721 198149 Negative_regulation EPHB2 MAP2K1 25226537 1130171 Negative_regulation EPHB2 MAP2K1 25500581 3033543 Negative_regulation EPHB2 MAP2K1 9432981 1602401 Negative_regulation EPHB2 MAP2K1 PMC4034031 2246251 Negative_regulation EPHB2 MAP2K2 16351709 1844973 Negative_regulation EPHB2 MAP2K2 20403177 659548 Negative_regulation EPHB2 MAP2K2 20868520 1859523 Negative_regulation EPHB2 MAP2K2 20886098 3048808 Negative_regulation EPHB2 MAP2K2 21347362 2503682 Negative_regulation EPHB2 MAP2K2 21776388 1686267 Negative_regulation EPHB2 MAP2K2 22564882 2180035 Negative_regulation EPHB2 MAP2K2 22941289 15971 Negative_regulation EPHB2 MAP2K2 24810962 2190473 Negative_regulation EPHB2 MAP2K2 24917786 931957 Negative_regulation EPHB2 MAP2K2 25149543 2198598 Negative_regulation EPHB2 MAP2K2 25165721 198150 Negative_regulation EPHB2 MAP2K2 25226537 1130172 Negative_regulation EPHB2 MAP2K3 16351709 1844974 Negative_regulation EPHB2 MAP2K3 20403177 659549 Negative_regulation EPHB2 MAP2K3 20868520 1859524 Negative_regulation EPHB2 MAP2K3 20886098 3048809 Negative_regulation EPHB2 MAP2K3 21347362 2503683 Negative_regulation EPHB2 MAP2K3 21776388 1686268 Negative_regulation EPHB2 MAP2K3 22564882 2180036 Negative_regulation EPHB2 MAP2K3 22941289 15972 Negative_regulation EPHB2 MAP2K3 24810962 2190474 Negative_regulation EPHB2 MAP2K3 24917786 931958 Negative_regulation EPHB2 MAP2K3 25149543 2198599 Negative_regulation EPHB2 MAP2K3 25165721 198151 Negative_regulation EPHB2 MAP2K3 25226537 1130173 Negative_regulation EPHB2 MAP2K4 16351709 1844975 Negative_regulation EPHB2 MAP2K4 20403177 659550 Negative_regulation EPHB2 MAP2K4 20868520 1859525 Negative_regulation EPHB2 MAP2K4 20886098 3048810 Negative_regulation EPHB2 MAP2K4 21347362 2503684 Negative_regulation EPHB2 MAP2K4 21776388 1686269 Negative_regulation EPHB2 MAP2K4 22564882 2180037 Negative_regulation EPHB2 MAP2K4 22941289 15973 Negative_regulation EPHB2 MAP2K4 24810962 2190475 Negative_regulation EPHB2 MAP2K4 24917786 931959 Negative_regulation EPHB2 MAP2K4 25149543 2198600 Negative_regulation EPHB2 MAP2K4 25165721 198152 Negative_regulation EPHB2 MAP2K4 25226537 1130174 Negative_regulation EPHB2 MAP2K5 16351709 1844976 Negative_regulation EPHB2 MAP2K5 20403177 659551 Negative_regulation EPHB2 MAP2K5 20868520 1859526 Negative_regulation EPHB2 MAP2K5 20886098 3048811 Negative_regulation EPHB2 MAP2K5 21347362 2503685 Negative_regulation EPHB2 MAP2K5 21776388 1686270 Negative_regulation EPHB2 MAP2K5 22564882 2180038 Negative_regulation EPHB2 MAP2K5 22941289 15974 Negative_regulation EPHB2 MAP2K5 24810962 2190476 Negative_regulation EPHB2 MAP2K5 24917786 931960 Negative_regulation EPHB2 MAP2K5 25149543 2198601 Negative_regulation EPHB2 MAP2K5 25165721 198153 Negative_regulation EPHB2 MAP2K5 25226537 1130175 Negative_regulation EPHB2 MAP2K6 16351709 1844977 Negative_regulation EPHB2 MAP2K6 20403177 659552 Negative_regulation EPHB2 MAP2K6 20868520 1859527 Negative_regulation EPHB2 MAP2K6 20886098 3048812 Negative_regulation EPHB2 MAP2K6 21347362 2503686 Negative_regulation EPHB2 MAP2K6 21776388 1686271 Negative_regulation EPHB2 MAP2K6 22564882 2180039 Negative_regulation EPHB2 MAP2K6 22941289 15975 Negative_regulation EPHB2 MAP2K6 24810962 2190477 Negative_regulation EPHB2 MAP2K6 24917786 931961 Negative_regulation EPHB2 MAP2K6 25149543 2198602 Negative_regulation EPHB2 MAP2K6 25165721 198154 Negative_regulation EPHB2 MAP2K6 25226537 1130176 Negative_regulation EPHB2 MAP2K7 16351709 1844978 Negative_regulation EPHB2 MAP2K7 20403177 659553 Negative_regulation EPHB2 MAP2K7 20868520 1859528 Negative_regulation EPHB2 MAP2K7 20886098 3048813 Negative_regulation EPHB2 MAP2K7 21347362 2503687 Negative_regulation EPHB2 MAP2K7 21776388 1686272 Negative_regulation EPHB2 MAP2K7 22564882 2180040 Negative_regulation EPHB2 MAP2K7 22941289 15976 Negative_regulation EPHB2 MAP2K7 24810962 2190478 Negative_regulation EPHB2 MAP2K7 24917786 931962 Negative_regulation EPHB2 MAP2K7 25149543 2198603 Negative_regulation EPHB2 MAP2K7 25165721 198155 Negative_regulation EPHB2 MAP2K7 25226537 1130177 Negative_regulation EPHB2 MAP3K10 25155142 1917710 Negative_regulation EPHB2 MAP3K3 24957684 2232027 Negative_regulation EPHB2 MAP3K6 24957684 2232028 Negative_regulation EPHB2 MAP3K8 22216021 696805 Negative_regulation EPHB2 MAPK1 17264880 2374596 Negative_regulation EPHB2 MAPK1 19821775 1236726 Negative_regulation EPHB2 MAPK1 20526329 1924842 Negative_regulation EPHB2 MAPK1 20529221 34736 Negative_regulation EPHB2 MAPK1 20593014 2454305 Negative_regulation EPHB2 MAPK1 21120149 860371 Negative_regulation EPHB2 MAPK1 21451502 1918215 Negative_regulation EPHB2 MAPK1 21505453 436720 Negative_regulation EPHB2 MAPK1 22447027 1956932 Negative_regulation EPHB2 MAPK1 22447027 1956933 Negative_regulation EPHB2 MAPK1 22567028 634396 Negative_regulation EPHB2 MAPK1 22675451 2648410 Negative_regulation EPHB2 MAPK1 23951028 2833278 Negative_regulation EPHB2 MAPK1 24340098 2895049 Negative_regulation EPHB2 MAPK1 24701244 825493 Negative_regulation EPHB2 MAPK1 25165721 198156 Negative_regulation EPHB2 MAPK1 25171101 3004187 Negative_regulation EPHB2 MAPK1 25372283 3022971 Negative_regulation EPHB2 MAPK1 PMC3760629 1606132 Negative_regulation EPHB2 MAPK10 17264880 2374597 Negative_regulation EPHB2 MAPK10 19821775 1236727 Negative_regulation EPHB2 MAPK10 20526329 1924843 Negative_regulation EPHB2 MAPK10 20529221 34737 Negative_regulation EPHB2 MAPK10 20593014 2454306 Negative_regulation EPHB2 MAPK10 21120149 860372 Negative_regulation EPHB2 MAPK10 21451502 1918216 Negative_regulation EPHB2 MAPK10 21505453 436721 Negative_regulation EPHB2 MAPK10 22447027 1956934 Negative_regulation EPHB2 MAPK10 22447027 1956935 Negative_regulation EPHB2 MAPK10 22567028 634397 Negative_regulation EPHB2 MAPK10 22675451 2648411 Negative_regulation EPHB2 MAPK10 23951028 2833279 Negative_regulation EPHB2 MAPK10 24340098 2895050 Negative_regulation EPHB2 MAPK10 24701244 825494 Negative_regulation EPHB2 MAPK10 25165721 198157 Negative_regulation EPHB2 MAPK10 25171101 3004188 Negative_regulation EPHB2 MAPK10 25372283 3022972 Negative_regulation EPHB2 MAPK10 PMC3760629 1606133 Negative_regulation EPHB2 MAPK11 17264880 2374598 Negative_regulation EPHB2 MAPK11 19821775 1236728 Negative_regulation EPHB2 MAPK11 20526329 1924844 Negative_regulation EPHB2 MAPK11 20529221 34738 Negative_regulation EPHB2 MAPK11 20593014 2454307 Negative_regulation EPHB2 MAPK11 21120149 860373 Negative_regulation EPHB2 MAPK11 21451502 1918217 Negative_regulation EPHB2 MAPK11 21505453 436722 Negative_regulation EPHB2 MAPK11 22447027 1956936 Negative_regulation EPHB2 MAPK11 22447027 1956937 Negative_regulation EPHB2 MAPK11 22567028 634398 Negative_regulation EPHB2 MAPK11 22675451 2648412 Negative_regulation EPHB2 MAPK11 23951028 2833280 Negative_regulation EPHB2 MAPK11 24340098 2895051 Negative_regulation EPHB2 MAPK11 24701244 825495 Negative_regulation EPHB2 MAPK11 25165721 198158 Negative_regulation EPHB2 MAPK11 25171101 3004189 Negative_regulation EPHB2 MAPK11 25372283 3022973 Negative_regulation EPHB2 MAPK11 PMC3760629 1606134 Negative_regulation EPHB2 MAPK12 17264880 2374599 Negative_regulation EPHB2 MAPK12 19821775 1236729 Negative_regulation EPHB2 MAPK12 20526329 1924845 Negative_regulation EPHB2 MAPK12 20529221 34739 Negative_regulation EPHB2 MAPK12 20593014 2454308 Negative_regulation EPHB2 MAPK12 21120149 860374 Negative_regulation EPHB2 MAPK12 21451502 1918218 Negative_regulation EPHB2 MAPK12 21505453 436723 Negative_regulation EPHB2 MAPK12 22447027 1956938 Negative_regulation EPHB2 MAPK12 22447027 1956939 Negative_regulation EPHB2 MAPK12 22567028 634399 Negative_regulation EPHB2 MAPK12 22675451 2648413 Negative_regulation EPHB2 MAPK12 23951028 2833281 Negative_regulation EPHB2 MAPK12 24340098 2895052 Negative_regulation EPHB2 MAPK12 24701244 825496 Negative_regulation EPHB2 MAPK12 25165721 198159 Negative_regulation EPHB2 MAPK12 25171101 3004190 Negative_regulation EPHB2 MAPK12 25372283 3022974 Negative_regulation EPHB2 MAPK12 PMC3760629 1606135 Negative_regulation EPHB2 MAPK13 17264880 2374600 Negative_regulation EPHB2 MAPK13 19821775 1236730 Negative_regulation EPHB2 MAPK13 20526329 1924846 Negative_regulation EPHB2 MAPK13 20529221 34740 Negative_regulation EPHB2 MAPK13 20593014 2454309 Negative_regulation EPHB2 MAPK13 21120149 860375 Negative_regulation EPHB2 MAPK13 21451502 1918219 Negative_regulation EPHB2 MAPK13 21505453 436724 Negative_regulation EPHB2 MAPK13 22447027 1956940 Negative_regulation EPHB2 MAPK13 22447027 1956941 Negative_regulation EPHB2 MAPK13 22567028 634400 Negative_regulation EPHB2 MAPK13 22675451 2648414 Negative_regulation EPHB2 MAPK13 23951028 2833282 Negative_regulation EPHB2 MAPK13 24340098 2895053 Negative_regulation EPHB2 MAPK13 24701244 825497 Negative_regulation EPHB2 MAPK13 25165721 198160 Negative_regulation EPHB2 MAPK13 25171101 3004191 Negative_regulation EPHB2 MAPK13 25372283 3022975 Negative_regulation EPHB2 MAPK13 PMC3760629 1606136 Negative_regulation EPHB2 MAPK14 17264880 2374601 Negative_regulation EPHB2 MAPK14 19821775 1236731 Negative_regulation EPHB2 MAPK14 20526329 1924847 Negative_regulation EPHB2 MAPK14 20529221 34741 Negative_regulation EPHB2 MAPK14 20593014 2454310 Negative_regulation EPHB2 MAPK14 21120149 860376 Negative_regulation EPHB2 MAPK14 21451502 1918220 Negative_regulation EPHB2 MAPK14 21505453 436725 Negative_regulation EPHB2 MAPK14 22447027 1956942 Negative_regulation EPHB2 MAPK14 22447027 1956943 Negative_regulation EPHB2 MAPK14 22567028 634401 Negative_regulation EPHB2 MAPK14 22675451 2648415 Negative_regulation EPHB2 MAPK14 23951028 2833283 Negative_regulation EPHB2 MAPK14 24340098 2895054 Negative_regulation EPHB2 MAPK14 24701244 825498 Negative_regulation EPHB2 MAPK14 25165721 198161 Negative_regulation EPHB2 MAPK14 25171101 3004192 Negative_regulation EPHB2 MAPK14 25372283 3022976 Negative_regulation EPHB2 MAPK14 PMC3760629 1606137 Negative_regulation EPHB2 MAPK15 17264880 2374595 Negative_regulation EPHB2 MAPK15 19821775 1236725 Negative_regulation EPHB2 MAPK15 20526329 1924841 Negative_regulation EPHB2 MAPK15 20529221 34735 Negative_regulation EPHB2 MAPK15 20593014 2454304 Negative_regulation EPHB2 MAPK15 21120149 860370 Negative_regulation EPHB2 MAPK15 21451502 1918214 Negative_regulation EPHB2 MAPK15 21505453 436718 Negative_regulation EPHB2 MAPK15 22447027 1956930 Negative_regulation EPHB2 MAPK15 22447027 1956931 Negative_regulation EPHB2 MAPK15 22567028 634392 Negative_regulation EPHB2 MAPK15 22675451 2648409 Negative_regulation EPHB2 MAPK15 23951028 2833277 Negative_regulation EPHB2 MAPK15 24340098 2895048 Negative_regulation EPHB2 MAPK15 24701244 825492 Negative_regulation EPHB2 MAPK15 25165721 198147 Negative_regulation EPHB2 MAPK15 25171101 3004186 Negative_regulation EPHB2 MAPK15 25372283 3022970 Negative_regulation EPHB2 MAPK15 PMC3760629 1606131 Negative_regulation EPHB2 MAPK3 14997206 424351 Negative_regulation EPHB2 MAPK3 17264880 2374602 Negative_regulation EPHB2 MAPK3 19531241 253542 Negative_regulation EPHB2 MAPK3 19821775 1236732 Negative_regulation EPHB2 MAPK3 20526329 1924848 Negative_regulation EPHB2 MAPK3 20529221 34742 Negative_regulation EPHB2 MAPK3 20593014 2454311 Negative_regulation EPHB2 MAPK3 21120149 860377 Negative_regulation EPHB2 MAPK3 21451502 1918221 Negative_regulation EPHB2 MAPK3 21505453 436726 Negative_regulation EPHB2 MAPK3 22447027 1956944 Negative_regulation EPHB2 MAPK3 22447027 1956945 Negative_regulation EPHB2 MAPK3 22567028 634402 Negative_regulation EPHB2 MAPK3 22675451 2648416 Negative_regulation EPHB2 MAPK3 23951028 2833284 Negative_regulation EPHB2 MAPK3 24340098 2895055 Negative_regulation EPHB2 MAPK3 24701244 825499 Negative_regulation EPHB2 MAPK3 24748172 2956014 Negative_regulation EPHB2 MAPK3 25165721 198162 Negative_regulation EPHB2 MAPK3 25171101 3004193 Negative_regulation EPHB2 MAPK3 25372283 3022977 Negative_regulation EPHB2 MAPK3 PMC3760629 1606138 Negative_regulation EPHB2 MAPK4 17264880 2374603 Negative_regulation EPHB2 MAPK4 19821775 1236733 Negative_regulation EPHB2 MAPK4 20526329 1924849 Negative_regulation EPHB2 MAPK4 20529221 34743 Negative_regulation EPHB2 MAPK4 20593014 2454312 Negative_regulation EPHB2 MAPK4 21120149 860378 Negative_regulation EPHB2 MAPK4 21451502 1918222 Negative_regulation EPHB2 MAPK4 21505453 436727 Negative_regulation EPHB2 MAPK4 22447027 1956946 Negative_regulation EPHB2 MAPK4 22447027 1956947 Negative_regulation EPHB2 MAPK4 22567028 634403 Negative_regulation EPHB2 MAPK4 22675451 2648417 Negative_regulation EPHB2 MAPK4 23951028 2833285 Negative_regulation EPHB2 MAPK4 24340098 2895056 Negative_regulation EPHB2 MAPK4 24701244 825500 Negative_regulation EPHB2 MAPK4 25165721 198163 Negative_regulation EPHB2 MAPK4 25171101 3004194 Negative_regulation EPHB2 MAPK4 25372283 3022978 Negative_regulation EPHB2 MAPK4 PMC3760629 1606139 Negative_regulation EPHB2 MAPK6 17264880 2374604 Negative_regulation EPHB2 MAPK6 19821775 1236734 Negative_regulation EPHB2 MAPK6 20526329 1924850 Negative_regulation EPHB2 MAPK6 20529221 34744 Negative_regulation EPHB2 MAPK6 20593014 2454313 Negative_regulation EPHB2 MAPK6 21120149 860379 Negative_regulation EPHB2 MAPK6 21451502 1918223 Negative_regulation EPHB2 MAPK6 21505453 436728 Negative_regulation EPHB2 MAPK6 22447027 1956948 Negative_regulation EPHB2 MAPK6 22447027 1956949 Negative_regulation EPHB2 MAPK6 22567028 634404 Negative_regulation EPHB2 MAPK6 22675451 2648418 Negative_regulation EPHB2 MAPK6 23951028 2833286 Negative_regulation EPHB2 MAPK6 24340098 2895057 Negative_regulation EPHB2 MAPK6 24701244 825501 Negative_regulation EPHB2 MAPK6 25165721 198164 Negative_regulation EPHB2 MAPK6 25171101 3004195 Negative_regulation EPHB2 MAPK6 25372283 3022979 Negative_regulation EPHB2 MAPK6 PMC3760629 1606140 Negative_regulation EPHB2 MAPK7 17264880 2374605 Negative_regulation EPHB2 MAPK7 19821775 1236735 Negative_regulation EPHB2 MAPK7 20526329 1924851 Negative_regulation EPHB2 MAPK7 20529221 34745 Negative_regulation EPHB2 MAPK7 20593014 2454314 Negative_regulation EPHB2 MAPK7 21120149 860380 Negative_regulation EPHB2 MAPK7 21451502 1918224 Negative_regulation EPHB2 MAPK7 21505453 436729 Negative_regulation EPHB2 MAPK7 22447027 1956950 Negative_regulation EPHB2 MAPK7 22447027 1956951 Negative_regulation EPHB2 MAPK7 22567028 634405 Negative_regulation EPHB2 MAPK7 22675451 2648419 Negative_regulation EPHB2 MAPK7 23951028 2833287 Negative_regulation EPHB2 MAPK7 24340098 2895058 Negative_regulation EPHB2 MAPK7 24701244 825502 Negative_regulation EPHB2 MAPK7 25165721 198165 Negative_regulation EPHB2 MAPK7 25171101 3004196 Negative_regulation EPHB2 MAPK7 25372283 3022980 Negative_regulation EPHB2 MAPK7 PMC3760629 1606141 Negative_regulation EPHB2 MAPK8 17264880 2374606 Negative_regulation EPHB2 MAPK8 19821775 1236736 Negative_regulation EPHB2 MAPK8 20526329 1924852 Negative_regulation EPHB2 MAPK8 20529221 34746 Negative_regulation EPHB2 MAPK8 20593014 2454315 Negative_regulation EPHB2 MAPK8 21120149 860381 Negative_regulation EPHB2 MAPK8 21451502 1918225 Negative_regulation EPHB2 MAPK8 21505453 436730 Negative_regulation EPHB2 MAPK8 22447027 1956952 Negative_regulation EPHB2 MAPK8 22447027 1956953 Negative_regulation EPHB2 MAPK8 22496888 2617744 Negative_regulation EPHB2 MAPK8 22567028 634406 Negative_regulation EPHB2 MAPK8 22675451 2648420 Negative_regulation EPHB2 MAPK8 23951028 2833288 Negative_regulation EPHB2 MAPK8 24340098 2895059 Negative_regulation EPHB2 MAPK8 24701244 825503 Negative_regulation EPHB2 MAPK8 25165721 198166 Negative_regulation EPHB2 MAPK8 25171101 3004197 Negative_regulation EPHB2 MAPK8 25372283 3022981 Negative_regulation EPHB2 MAPK8 PMC3760629 1606142 Negative_regulation EPHB2 MAPK9 17264880 2374607 Negative_regulation EPHB2 MAPK9 19821775 1236737 Negative_regulation EPHB2 MAPK9 20526329 1924853 Negative_regulation EPHB2 MAPK9 20529221 34747 Negative_regulation EPHB2 MAPK9 20593014 2454316 Negative_regulation EPHB2 MAPK9 21120149 860382 Negative_regulation EPHB2 MAPK9 21451502 1918226 Negative_regulation EPHB2 MAPK9 21505453 436731 Negative_regulation EPHB2 MAPK9 22447027 1956954 Negative_regulation EPHB2 MAPK9 22447027 1956955 Negative_regulation EPHB2 MAPK9 22567028 634407 Negative_regulation EPHB2 MAPK9 22675451 2648421 Negative_regulation EPHB2 MAPK9 23472073 2763834 Negative_regulation EPHB2 MAPK9 23951028 2833289 Negative_regulation EPHB2 MAPK9 24340098 2895060 Negative_regulation EPHB2 MAPK9 24701244 825504 Negative_regulation EPHB2 MAPK9 25165721 198167 Negative_regulation EPHB2 MAPK9 25171101 3004198 Negative_regulation EPHB2 MAPK9 25372283 3022982 Negative_regulation EPHB2 MAPK9 PMC3760629 1606143 Negative_regulation EPHB2 MAPKAPK2 24917786 931963 Negative_regulation EPHB2 MARK1 20855497 1560233 Negative_regulation EPHB2 MARK1 24929539 1234225 Negative_regulation EPHB2 MARK2 20855497 1560231 Negative_regulation EPHB2 MARK2 24929539 1234224 Negative_regulation EPHB2 MARK3 20855497 1560234 Negative_regulation EPHB2 MARK3 24929539 1234226 Negative_regulation EPHB2 MARK4 20855497 1560230 Negative_regulation EPHB2 MARK4 24929539 1234222 Negative_regulation EPHB2 MATK 21772273 1933173 Negative_regulation EPHB2 MBTPS1 17449940 1634825 Negative_regulation EPHB2 MCOLN1 24223965 2877503 Negative_regulation EPHB2 MDM2 21389118 1788931 Negative_regulation EPHB2 MDM2 23342042 2741715 Negative_regulation EPHB2 MED1 23424281 2281865 Negative_regulation EPHB2 MED12 23424281 2281851 Negative_regulation EPHB2 MED13 23424281 2281856 Negative_regulation EPHB2 MED14 23424281 2281858 Negative_regulation EPHB2 MED15 23424281 2281852 Negative_regulation EPHB2 MED17 23424281 2281860 Negative_regulation EPHB2 MED23 23424281 2281859 Negative_regulation EPHB2 MED24 23424281 2281857 Negative_regulation EPHB2 MED25 23424281 2281863 Negative_regulation EPHB2 MED26 23424281 2281861 Negative_regulation EPHB2 MED4 23424281 2281853 Negative_regulation EPHB2 MED6 23424281 2281854 Negative_regulation EPHB2 MED7 23424281 2281862 Negative_regulation EPHB2 MED8 23424281 2281855 Negative_regulation EPHB2 MEN1 20639902 2133008 Negative_regulation EPHB2 MET 23327903 2182153 Negative_regulation EPHB2 MET 23327903 2182158 Negative_regulation EPHB2 MET 23826330 2812056 Negative_regulation EPHB2 MET 24287743 502487 Negative_regulation EPHB2 MET 25057499 195507 Negative_regulation EPHB2 MIA 21368873 550839 Negative_regulation EPHB2 MIA 24349210 2897130 Negative_regulation EPHB2 MICE 22044622 124274 Negative_regulation EPHB2 MIR148A 23554686 1225986 Negative_regulation EPHB2 MIR148A 23554686 1225987 Negative_regulation EPHB2 MKNK1 24917786 931964 Negative_regulation EPHB2 MLST8 21278786 2137801 Negative_regulation EPHB2 MLST8 22668349 212843 Negative_regulation EPHB2 MLST8 23437362 2756625 Negative_regulation EPHB2 MLST8 24212820 498646 Negative_regulation EPHB2 MLST8 24212820 498785 Negative_regulation EPHB2 MLST8 24393708 2186574 Negative_regulation EPHB2 MMP1 21878106 3169083 Negative_regulation EPHB2 MMP1 24352036 1632404 Negative_regulation EPHB2 MMP10 21878106 3169084 Negative_regulation EPHB2 MMP11 21878106 3169085 Negative_regulation EPHB2 MMP12 21878106 3169086 Negative_regulation EPHB2 MMP13 21878106 3169087 Negative_regulation EPHB2 MMP14 21878106 3169088 Negative_regulation EPHB2 MMP14 24180670 270275 Negative_regulation EPHB2 MMP15 21878106 3169089 Negative_regulation EPHB2 MMP16 21878106 3169090 Negative_regulation EPHB2 MMP17 21878106 3169091 Negative_regulation EPHB2 MMP19 21878106 3169092 Negative_regulation EPHB2 MMP2 21878106 3169093 Negative_regulation EPHB2 MMP2 24376819 2902319 Negative_regulation EPHB2 MMP20 21878106 3169094 Negative_regulation EPHB2 MMP21 21878106 3169081 Negative_regulation EPHB2 MMP24 21878106 3169095 Negative_regulation EPHB2 MMP25 21878106 3169078 Negative_regulation EPHB2 MMP26 21878106 3169079 Negative_regulation EPHB2 MMP27 21878106 3169080 Negative_regulation EPHB2 MMP28 21878106 3169082 Negative_regulation EPHB2 MMP3 21878106 3169096 Negative_regulation EPHB2 MMP7 21878106 3169097 Negative_regulation EPHB2 MMP8 21878106 3169098 Negative_regulation EPHB2 MMP9 21878106 3169099 Negative_regulation EPHB2 MMP9 23183822 2181723 Negative_regulation EPHB2 MMP9 24376819 2902320 Negative_regulation EPHB2 MOCOS 11877481 1523105 Negative_regulation EPHB2 MPZ 24993693 1087515 Negative_regulation EPHB2 MTOR 21278786 2137717 Negative_regulation EPHB2 MTOR 21278786 2137718 Negative_regulation EPHB2 MTOR 21278786 2137803 Negative_regulation EPHB2 MTOR 21484200 1652965 Negative_regulation EPHB2 MTOR 22668349 212848 Negative_regulation EPHB2 MTOR 22851969 1674133 Negative_regulation EPHB2 MTOR 23392177 559845 Negative_regulation EPHB2 MTOR 23437362 2756585 Negative_regulation EPHB2 MTOR 23437362 2756586 Negative_regulation EPHB2 MTOR 23437362 2756593 Negative_regulation EPHB2 MTOR 23437362 2756594 Negative_regulation EPHB2 MTOR 23437362 2756628 Negative_regulation EPHB2 MTOR 23818927 820588 Negative_regulation EPHB2 MTOR 24212820 498648 Negative_regulation EPHB2 MTOR 24212820 498787 Negative_regulation EPHB2 MTOR 24212820 498803 Negative_regulation EPHB2 MTOR 24393708 2186576 Negative_regulation EPHB2 MTOR 24416349 2907930 Negative_regulation EPHB2 MTOR 24710474 618138 Negative_regulation EPHB2 MTOR 24714637 2950104 Negative_regulation EPHB2 MTOR 24810962 2190471 Negative_regulation EPHB2 MTOR 25180793 3004346 Negative_regulation EPHB2 MTOR 25180793 3004354 Negative_regulation EPHB2 MTOR 25295009 966039 Negative_regulation EPHB2 MYC 16899113 1845529 Negative_regulation EPHB2 MYLIP 22507670 125328 Negative_regulation EPHB2 MYLIP 22802911 2219428 Negative_regulation EPHB2 MYLIP 24009080 2184717 Negative_regulation EPHB2 MYLIP 24009080 2184720 Negative_regulation EPHB2 MYLIP 24009080 2184721 Negative_regulation EPHB2 MYLIP 24009080 2184724 Negative_regulation EPHB2 MYLIP 24009080 2184728 Negative_regulation EPHB2 MYLIP 24312276 2888371 Negative_regulation EPHB2 MYLIP 25058005 2992025 Negative_regulation EPHB2 MYLIP 25275294 2202347 Negative_regulation EPHB2 MYLIP 25275294 2202476 Negative_regulation EPHB2 MYLIP 25275294 2202518 Negative_regulation EPHB2 MYLIP 25275294 2202575 Negative_regulation EPHB2 MYLIP 25275294 2202632 Negative_regulation EPHB2 MYLIP 25352952 987300 Negative_regulation EPHB2 NA 18629305 793273 Negative_regulation EPHB2 NA 18629305 793380 Negative_regulation EPHB2 NA 20526329 1924854 Negative_regulation EPHB2 NA 22867088 2233301 Negative_regulation EPHB2 NA 23555655 2774712 Negative_regulation EPHB2 NA 25056546 1128668 Negative_regulation EPHB2 NA 25248126 3009295 Negative_regulation EPHB2 NCOA3 23388133 267739 Negative_regulation EPHB2 NCSTN 19247475 2406535 Negative_regulation EPHB2 NCSTN 19247475 2406547 Negative_regulation EPHB2 NDRG1 23287991 439733 Negative_regulation EPHB2 NELFCD 22238675 2586915 Negative_regulation EPHB2 NELFCD 22238675 2586975 Negative_regulation EPHB2 NELFCD 22238675 2587033 Negative_regulation EPHB2 NELFCD 22238675 2587053 Negative_regulation EPHB2 NENF 23805070 938214 Negative_regulation EPHB2 NF1 19901965 2128126 Negative_regulation EPHB2 NF1 21949657 2326443 Negative_regulation EPHB2 NF1 23723176 702932 Negative_regulation EPHB2 NF1 24278035 2353149 Negative_regulation EPHB2 NF1 25026295 2196398 Negative_regulation EPHB2 NF1 25535838 762924 Negative_regulation EPHB2 NF2 20890305 2136424 Negative_regulation EPHB2 NF2 20890305 2136425 Negative_regulation EPHB2 NF2 20890305 2136426 Negative_regulation EPHB2 NF2 24393766 2186640 Negative_regulation EPHB2 NFE2L2 21270272 717456 Negative_regulation EPHB2 NFE2L2 21270272 717465 Negative_regulation EPHB2 NFE2L2 21270272 717468 Negative_regulation EPHB2 NGFR 25149537 2198465 Negative_regulation EPHB2 NLRP12 24901306 2976806 Negative_regulation EPHB2 NM 24755316 784544 Negative_regulation EPHB2 NME1 24829611 1650684 Negative_regulation EPHB2 NOTCH1 18950493 524937 Negative_regulation EPHB2 NOTCH1 22074495 1863917 Negative_regulation EPHB2 NOTCH1 23908058 3227849 Negative_regulation EPHB2 NOTCH2 22074495 1863918 Negative_regulation EPHB2 NOTCH2 23908058 3227850 Negative_regulation EPHB2 NOTCH3 22074495 1863919 Negative_regulation EPHB2 NOTCH3 23908058 3227851 Negative_regulation EPHB2 NOTCH4 22074495 1863920 Negative_regulation EPHB2 NOTCH4 23908058 3227852 Negative_regulation EPHB2 NOV 19308688 495191 Negative_regulation EPHB2 NOV 19623482 1478579 Negative_regulation EPHB2 NOX1 19804648 1835286 Negative_regulation EPHB2 NOX1 19804648 1835287 Negative_regulation EPHB2 NOX1 19804648 1835288 Negative_regulation EPHB2 NOX1 19804648 1835289 Negative_regulation EPHB2 NOX1 24192910 1920117 Negative_regulation EPHB2 NOX3 19804648 1835290 Negative_regulation EPHB2 NOX3 19804648 1835291 Negative_regulation EPHB2 NOX3 19804648 1835292 Negative_regulation EPHB2 NOX3 19804648 1835293 Negative_regulation EPHB2 NOX4 18573911 1352967 Negative_regulation EPHB2 NOX4 19804648 1835294 Negative_regulation EPHB2 NOX4 19804648 1835295 Negative_regulation EPHB2 NOX4 19804648 1835296 Negative_regulation EPHB2 NOX4 19804648 1835297 Negative_regulation EPHB2 NOX5 19804648 1835282 Negative_regulation EPHB2 NOX5 19804648 1835283 Negative_regulation EPHB2 NOX5 19804648 1835284 Negative_regulation EPHB2 NOX5 19804648 1835285 Negative_regulation EPHB2 NPB 25093335 2995195 Negative_regulation EPHB2 NPY4R 21037577 1954566 Negative_regulation EPHB2 NPY6R 11956229 1280924 Negative_regulation EPHB2 NPY6R 11956229 1280925 Negative_regulation EPHB2 NPY6R 11956229 1280943 Negative_regulation EPHB2 NPY6R 14517202 1298841 Negative_regulation EPHB2 NPY6R 14517202 1298843 Negative_regulation EPHB2 NPY6R 18159242 2381573 Negative_regulation EPHB2 NPY6R 19254952 1165610 Negative_regulation EPHB2 NPY6R 20092633 284082 Negative_regulation EPHB2 NPY6R 22967907 1506575 Negative_regulation EPHB2 NPY6R PMC3284913 395647 Negative_regulation EPHB2 NQO1 24505400 2920794 Negative_regulation EPHB2 NR4A1 22648407 1203467 Negative_regulation EPHB2 NRAS 19804630 401925 Negative_regulation EPHB2 NRAS 19804630 401945 Negative_regulation EPHB2 NRAS 19877500 734749 Negative_regulation EPHB2 NRAS 20071468 1772930 Negative_regulation EPHB2 NRAS 20141835 516346 Negative_regulation EPHB2 NRAS 20562914 2132659 Negative_regulation EPHB2 NRAS 20802521 2135566 Negative_regulation EPHB2 NRAS 20926686 1783319 Negative_regulation EPHB2 NRAS 22701199 2234542 Negative_regulation EPHB2 NRAS 25275294 2202381 Negative_regulation EPHB2 NRAS 9314533 1463467 Negative_regulation EPHB2 NRAS 9432981 1602474 Negative_regulation EPHB2 NRN1 23066017 1205239 Negative_regulation EPHB2 NTRK1 22586581 722785 Negative_regulation EPHB2 NTRK1 24006492 1818264 Negative_regulation EPHB2 NTRK2 20156366 255288 Negative_regulation EPHB2 NTS 21961726 261157 Negative_regulation EPHB2 OPN1LW 21143914 1860543 Negative_regulation EPHB2 OPN1MW 21317295 717920 Negative_regulation EPHB2 PAK4 24312276 2888370 Negative_regulation EPHB2 PAK4 24471762 214366 Negative_regulation EPHB2 PAN2 23710442 181686 Negative_regulation EPHB2 PAN3 23710442 181687 Negative_regulation EPHB2 PARP1 24714091 1125919 Negative_regulation EPHB2 PARP10 24714091 1125914 Negative_regulation EPHB2 PARP11 24714091 1125911 Negative_regulation EPHB2 PARP12 24714091 1125912 Negative_regulation EPHB2 PARP14 24714091 1125923 Negative_regulation EPHB2 PARP15 24714091 1125917 Negative_regulation EPHB2 PARP16 24714091 1125915 Negative_regulation EPHB2 PARP2 24714091 1125921 Negative_regulation EPHB2 PARP3 24714091 1125922 Negative_regulation EPHB2 PARP4 24714091 1125920 Negative_regulation EPHB2 PARP6 24714091 1125918 Negative_regulation EPHB2 PARP8 24714091 1125916 Negative_regulation EPHB2 PARP9 24714091 1125913 Negative_regulation EPHB2 PAWR 23760770 1141776 Negative_regulation EPHB2 PAX6 23874217 2347524 Negative_regulation EPHB2 PCSK1 21853090 2543163 Negative_regulation EPHB2 PCSK1 21853090 2543199 Negative_regulation EPHB2 PCYT1A 24847227 861122 Negative_regulation EPHB2 PCYT1A 24847227 861123 Negative_regulation EPHB2 PCYT1A 24847227 861124 Negative_regulation EPHB2 PDGFRB 23686014 2117374 Negative_regulation EPHB2 PEA15 22105357 2144462 Negative_regulation EPHB2 PEA15 23552738 2156582 Negative_regulation EPHB2 PEBP1 17958888 1242722 Negative_regulation EPHB2 PEBP1 17958888 1242795 Negative_regulation EPHB2 PEBP1 20378935 27162 Negative_regulation EPHB2 PEBP1 22623902 3153310 Negative_regulation EPHB2 PECAM1 12177047 1286333 Negative_regulation EPHB2 PHKA2 22096562 2571717 Negative_regulation EPHB2 PHLDA1 18597688 251128 Negative_regulation EPHB2 PHLDA1 18597688 251129 Negative_regulation EPHB2 PHLDA1 18597688 251140 Negative_regulation EPHB2 PHLDA1 18597688 251142 Negative_regulation EPHB2 PHOSPHO1 24826069 1917028 Negative_regulation EPHB2 PHOSPHO2 24826069 1917029 Negative_regulation EPHB2 PI3 23776078 1572546 Negative_regulation EPHB2 PIK3CA 18091994 2381406 Negative_regulation EPHB2 PIK3CA 20712893 1858039 Negative_regulation EPHB2 PIK3CA 20712893 1858096 Negative_regulation EPHB2 PIK3CA 21278786 2137719 Negative_regulation EPHB2 PIK3CA 21278786 2137720 Negative_regulation EPHB2 PIK3CA 21278786 2137721 Negative_regulation EPHB2 PIK3CA 21725367 2140727 Negative_regulation EPHB2 PIK3CA 22477519 1238999 Negative_regulation EPHB2 PIK3CA 22668349 212849 Negative_regulation EPHB2 PIK3CA 22675451 2648300 Negative_regulation EPHB2 PIK3CA 23076254 605015 Negative_regulation EPHB2 PIK3CA 23727661 218535 Negative_regulation EPHB2 PIK3CA 23840272 820834 Negative_regulation EPHB2 PIK3CA 23986484 1487176 Negative_regulation EPHB2 PIK3CA 24071646 566568 Negative_regulation EPHB2 PIK3CA 24272818 2185573 Negative_regulation EPHB2 PIK3CA 24586357 2924397 Negative_regulation EPHB2 PIK3CA PMC3109490 927572 Negative_regulation EPHB2 PIK3R1 18091994 2381407 Negative_regulation EPHB2 PIK3R1 20712893 1858040 Negative_regulation EPHB2 PIK3R1 20712893 1858097 Negative_regulation EPHB2 PIK3R1 21278786 2137722 Negative_regulation EPHB2 PIK3R1 21278786 2137723 Negative_regulation EPHB2 PIK3R1 21278786 2137724 Negative_regulation EPHB2 PIK3R1 21725367 2140728 Negative_regulation EPHB2 PIK3R1 22477519 1239000 Negative_regulation EPHB2 PIK3R1 22668349 212850 Negative_regulation EPHB2 PIK3R1 22675451 2648301 Negative_regulation EPHB2 PIK3R1 23076254 605016 Negative_regulation EPHB2 PIK3R1 23727661 218536 Negative_regulation EPHB2 PIK3R1 23840272 820835 Negative_regulation EPHB2 PIK3R1 23986484 1487177 Negative_regulation EPHB2 PIK3R1 24071646 566569 Negative_regulation EPHB2 PIK3R1 24272818 2185574 Negative_regulation EPHB2 PIK3R1 24586357 2924398 Negative_regulation EPHB2 PIK3R1 PMC3109490 927573 Negative_regulation EPHB2 PKN1 21209852 2491421 Negative_regulation EPHB2 PLAU 23843896 3177319 Negative_regulation EPHB2 PLAUR 19242538 2406262 Negative_regulation EPHB2 PLAUR 19242538 2406265 Negative_regulation EPHB2 PLAUR 23843896 3177320 Negative_regulation EPHB2 PLD1 22105357 2144463 Negative_regulation EPHB2 PMPCB 23237212 625265 Negative_regulation EPHB2 PNLIP 25610476 827678 Negative_regulation EPHB2 POLDIP2 11305949 457127 Negative_regulation EPHB2 POLDIP2 20107538 1037428 Negative_regulation EPHB2 POLDIP2 23060802 959387 Negative_regulation EPHB2 POLDIP2 23670595 1106842 Negative_regulation EPHB2 POLDIP2 25068892 622533 Negative_regulation EPHB2 POT1 23360994 1934898 Negative_regulation EPHB2 PPFIA1 25414766 206508 Negative_regulation EPHB2 PPP1R1B 24204683 2873274 Negative_regulation EPHB2 PPP1R3A 24558305 1615147 Negative_regulation EPHB2 PPP2CA 17875674 1547014 Negative_regulation EPHB2 PPP2CA 19602257 385614 Negative_regulation EPHB2 PPP2CA 19897477 1167221 Negative_regulation EPHB2 PPP2CA 20356833 1186565 Negative_regulation EPHB2 PPP2CA 22114700 2573487 Negative_regulation EPHB2 PPP2CA 22739989 556420 Negative_regulation EPHB2 PPP2CA 23060802 959334 Negative_regulation EPHB2 PPP2CA 23060802 959354 Negative_regulation EPHB2 PPP2CA 23060802 959388 Negative_regulation EPHB2 PPP2CA 23427196 780087 Negative_regulation EPHB2 PPP2CA 24885237 1233656 Negative_regulation EPHB2 PPP2CA 24923411 132733 Negative_regulation EPHB2 PPP2CA 24923411 132736 Negative_regulation EPHB2 PPP2R1A 17875674 1547015 Negative_regulation EPHB2 PPP2R1A 19602257 385615 Negative_regulation EPHB2 PPP2R1A 19897477 1167222 Negative_regulation EPHB2 PPP2R1A 20356833 1186566 Negative_regulation EPHB2 PPP2R1A 22114700 2573488 Negative_regulation EPHB2 PPP2R1A 22739989 556421 Negative_regulation EPHB2 PPP2R1A 23060802 959335 Negative_regulation EPHB2 PPP2R1A 23060802 959355 Negative_regulation EPHB2 PPP2R1A 23060802 959389 Negative_regulation EPHB2 PPP2R1A 23427196 780088 Negative_regulation EPHB2 PPP2R1A 24885237 1233657 Negative_regulation EPHB2 PPP2R1A 24923411 132734 Negative_regulation EPHB2 PPP2R1A 24923411 132737 Negative_regulation EPHB2 PPP2R2B 17875674 1547016 Negative_regulation EPHB2 PPP2R2B 19602257 385616 Negative_regulation EPHB2 PPP2R2B 19897477 1167223 Negative_regulation EPHB2 PPP2R2B 20356833 1186567 Negative_regulation EPHB2 PPP2R2B 22114700 2573489 Negative_regulation EPHB2 PPP2R2B 22739989 556422 Negative_regulation EPHB2 PPP2R2B 23060802 959336 Negative_regulation EPHB2 PPP2R2B 23060802 959356 Negative_regulation EPHB2 PPP2R2B 23060802 959390 Negative_regulation EPHB2 PPP2R2B 23427196 780089 Negative_regulation EPHB2 PPP2R2B 24885237 1233658 Negative_regulation EPHB2 PPP2R2B 24923411 132735 Negative_regulation EPHB2 PPP2R2B 24923411 132738 Negative_regulation EPHB2 PRDM14 23670199 786265 Negative_regulation EPHB2 PRDX2 21969835 3172940 Negative_regulation EPHB2 PRDX2 23249388 341578 Negative_regulation EPHB2 PRDX2 23249388 341601 Negative_regulation EPHB2 PRDX2 23418492 2754186 Negative_regulation EPHB2 PRDX2 24204683 2873275 Negative_regulation EPHB2 PRH2 24795692 935550 Negative_regulation EPHB2 PRKAA1 22269797 1898930 Negative_regulation EPHB2 PRKAA1 22751115 2147835 Negative_regulation EPHB2 PRKAA1 24602453 1872567 Negative_regulation EPHB2 PRKAA1 24602453 1872714 Negative_regulation EPHB2 PRKAA1 24617546 214451 Negative_regulation EPHB2 PRKAA1 25045295 1712279 Negative_regulation EPHB2 PRKAA1 PMC4121617 1876077 Negative_regulation EPHB2 PRKAA2 22269797 1898931 Negative_regulation EPHB2 PRKAA2 22751115 2147836 Negative_regulation EPHB2 PRKAA2 24602453 1872568 Negative_regulation EPHB2 PRKAA2 24602453 1872715 Negative_regulation EPHB2 PRKAA2 24617546 214452 Negative_regulation EPHB2 PRKAA2 25045295 1712280 Negative_regulation EPHB2 PRKAA2 PMC4121617 1876078 Negative_regulation EPHB2 PRKAB1 22269797 1898932 Negative_regulation EPHB2 PRKAB1 22751115 2147837 Negative_regulation EPHB2 PRKAB1 24602453 1872569 Negative_regulation EPHB2 PRKAB1 24602453 1872716 Negative_regulation EPHB2 PRKAB1 24617546 214453 Negative_regulation EPHB2 PRKAB1 25045295 1712281 Negative_regulation EPHB2 PRKAB1 PMC4121617 1876079 Negative_regulation EPHB2 PRKAB2 22269797 1898933 Negative_regulation EPHB2 PRKAB2 22751115 2147838 Negative_regulation EPHB2 PRKAB2 24602453 1872570 Negative_regulation EPHB2 PRKAB2 24602453 1872717 Negative_regulation EPHB2 PRKAB2 24617546 214454 Negative_regulation EPHB2 PRKAB2 25045295 1712282 Negative_regulation EPHB2 PRKAB2 PMC4121617 1876080 Negative_regulation EPHB2 PRKACB 20971121 1642352 Negative_regulation EPHB2 PRKACB 21695205 2529748 Negative_regulation EPHB2 PRKACB 22384111 2603908 Negative_regulation EPHB2 PRKACB 22384111 2605807 Negative_regulation EPHB2 PRKACB 22384111 2605861 Negative_regulation EPHB2 PRKACB 24409147 953561 Negative_regulation EPHB2 PRKACB 24842369 1576255 Negative_regulation EPHB2 PRKACB 24842369 1576323 Negative_regulation EPHB2 PRKACG 20971121 1642353 Negative_regulation EPHB2 PRKACG 21695205 2529749 Negative_regulation EPHB2 PRKACG 22384111 2603909 Negative_regulation EPHB2 PRKACG 22384111 2605808 Negative_regulation EPHB2 PRKACG 22384111 2605862 Negative_regulation EPHB2 PRKACG 24409147 953562 Negative_regulation EPHB2 PRKACG 24842369 1576256 Negative_regulation EPHB2 PRKACG 24842369 1576324 Negative_regulation EPHB2 PRKAG1 22269797 1898934 Negative_regulation EPHB2 PRKAG1 22751115 2147839 Negative_regulation EPHB2 PRKAG1 24602453 1872571 Negative_regulation EPHB2 PRKAG1 24602453 1872718 Negative_regulation EPHB2 PRKAG1 24617546 214455 Negative_regulation EPHB2 PRKAG1 25045295 1712283 Negative_regulation EPHB2 PRKAG1 PMC4121617 1876081 Negative_regulation EPHB2 PRKAG2 22269797 1898935 Negative_regulation EPHB2 PRKAG2 22751115 2147840 Negative_regulation EPHB2 PRKAG2 24602453 1872572 Negative_regulation EPHB2 PRKAG2 24602453 1872719 Negative_regulation EPHB2 PRKAG2 24617546 214456 Negative_regulation EPHB2 PRKAG2 25045295 1712284 Negative_regulation EPHB2 PRKAG2 PMC4121617 1876082 Negative_regulation EPHB2 PRKAR1A 20971121 1642354 Negative_regulation EPHB2 PRKAR1A 21695205 2529750 Negative_regulation EPHB2 PRKAR1A 22384111 2603910 Negative_regulation EPHB2 PRKAR1A 22384111 2605809 Negative_regulation EPHB2 PRKAR1A 22384111 2605863 Negative_regulation EPHB2 PRKAR1A 24409147 953563 Negative_regulation EPHB2 PRKAR1A 24842369 1576257 Negative_regulation EPHB2 PRKAR1A 24842369 1576325 Negative_regulation EPHB2 PRKAR1B 20971121 1642355 Negative_regulation EPHB2 PRKAR1B 21695205 2529751 Negative_regulation EPHB2 PRKAR1B 22384111 2603911 Negative_regulation EPHB2 PRKAR1B 22384111 2605810 Negative_regulation EPHB2 PRKAR1B 22384111 2605864 Negative_regulation EPHB2 PRKAR1B 24409147 953564 Negative_regulation EPHB2 PRKAR1B 24842369 1576258 Negative_regulation EPHB2 PRKAR1B 24842369 1576326 Negative_regulation EPHB2 PRKAR2A 20971121 1642356 Negative_regulation EPHB2 PRKAR2A 21695205 2529752 Negative_regulation EPHB2 PRKAR2A 22384111 2603912 Negative_regulation EPHB2 PRKAR2A 22384111 2605811 Negative_regulation EPHB2 PRKAR2A 22384111 2605865 Negative_regulation EPHB2 PRKAR2A 24409147 953565 Negative_regulation EPHB2 PRKAR2A 24842369 1576259 Negative_regulation EPHB2 PRKAR2A 24842369 1576327 Negative_regulation EPHB2 PRKAR2B 20971121 1642357 Negative_regulation EPHB2 PRKAR2B 21695205 2529753 Negative_regulation EPHB2 PRKAR2B 22384111 2603913 Negative_regulation EPHB2 PRKAR2B 22384111 2605812 Negative_regulation EPHB2 PRKAR2B 22384111 2605866 Negative_regulation EPHB2 PRKAR2B 24409147 953566 Negative_regulation EPHB2 PRKAR2B 24842369 1576260 Negative_regulation EPHB2 PRKAR2B 24842369 1576328 Negative_regulation EPHB2 PRKCDBP 24069528 750696 Negative_regulation EPHB2 PRKCDBP 24069528 750746 Negative_regulation EPHB2 PSEN1 19247475 2406538 Negative_regulation EPHB2 PSEN1 19247475 2406550 Negative_regulation EPHB2 PSENEN 19247475 2406537 Negative_regulation EPHB2 PSENEN 19247475 2406549 Negative_regulation EPHB2 PSIP1 22046349 2566517 Negative_regulation EPHB2 PSIP1 22046349 2566723 Negative_regulation EPHB2 PSIP1 22046349 2566771 Negative_regulation EPHB2 PSIP1 23589723 818572 Negative_regulation EPHB2 PSMG1 24098484 2856604 Negative_regulation EPHB2 PTEN 9832564 1472252 Negative_regulation EPHB2 PTGDR2 21364986 2504801 Negative_regulation EPHB2 PTGER4 24842369 1576261 Negative_regulation EPHB2 PTK2 11149924 1267003 Negative_regulation EPHB2 PTK2 11956229 1280876 Negative_regulation EPHB2 PTK2 11956229 1280877 Negative_regulation EPHB2 PTK2 23286511 587801 Negative_regulation EPHB2 PTK6 23286511 587802 Negative_regulation EPHB2 PTK7 23286511 587803 Negative_regulation EPHB2 PTK7 24618420 539547 Negative_regulation EPHB2 PTP4A3 23929599 781759 Negative_regulation EPHB2 PTPN1 21123182 1189580 Negative_regulation EPHB2 PTPN1 PMC4212306 3206469 Negative_regulation EPHB2 PTPN11 11956229 1280883 Negative_regulation EPHB2 PTPN11 22235335 2585899 Negative_regulation EPHB2 PTPN11 22777356 2147979 Negative_regulation EPHB2 PTPN11 22777356 2148014 Negative_regulation EPHB2 PTPN11 25296975 2204277 Negative_regulation EPHB2 PTPN12 23237212 625266 Negative_regulation EPHB2 PTPN13 19734941 2126765 Negative_regulation EPHB2 PTPN13 PMC4261712 1049449 Negative_regulation EPHB2 PTPN22 23991106 2840941 Negative_regulation EPHB2 PTPN3 20353590 1625995 Negative_regulation EPHB2 PTPN6 14662744 1302165 Negative_regulation EPHB2 PTPN6 17420266 1545165 Negative_regulation EPHB2 PTPN6 19144997 1991894 Negative_regulation EPHB2 PTPRA 23826330 2812057 Negative_regulation EPHB2 PTX3 11897012 389925 Negative_regulation EPHB2 PTX3 21686182 1091086 Negative_regulation EPHB2 PTX3 22654837 876287 Negative_regulation EPHB2 PTX3 23549262 1104675 Negative_regulation EPHB2 PTX3 23805070 938215 Negative_regulation EPHB2 PTX3 24521094 539395 Negative_regulation EPHB2 PTX3 24743392 2955169 Negative_regulation EPHB2 PTX4 11897012 389924 Negative_regulation EPHB2 PTX4 21686182 1091085 Negative_regulation EPHB2 PTX4 22654837 876286 Negative_regulation EPHB2 PTX4 23549262 1104673 Negative_regulation EPHB2 PTX4 23805070 938213 Negative_regulation EPHB2 PTX4 24521094 539394 Negative_regulation EPHB2 PTX4 24743392 2955168 Negative_regulation EPHB2 RAB8A 20944813 1491970 Negative_regulation EPHB2 RAB8A 20944813 1492043 Negative_regulation EPHB2 RAC1 20711231 2133710 Negative_regulation EPHB2 RAC1 22384148 2606708 Negative_regulation EPHB2 RAC1 22693568 2650756 Negative_regulation EPHB2 RAC2 20711231 2133711 Negative_regulation EPHB2 RAC2 22693568 2650757 Negative_regulation EPHB2 RAC3 20711231 2133712 Negative_regulation EPHB2 RAC3 22693568 2650758 Negative_regulation EPHB2 RAD1 22662154 2647088 Negative_regulation EPHB2 RAD17 22662154 2647089 Negative_regulation EPHB2 RAD18 22662154 2647087 Negative_regulation EPHB2 RAD21 22662154 2647090 Negative_regulation EPHB2 RAD50 22662154 2647091 Negative_regulation EPHB2 RAD50 23360994 1934901 Negative_regulation EPHB2 RAD51 22662154 2647092 Negative_regulation EPHB2 RAD52 22662154 2647093 Negative_regulation EPHB2 RAF1 23549166 543152 Negative_regulation EPHB2 RAF1 23549166 543156 Negative_regulation EPHB2 RANBP9 23118896 2711942 Negative_regulation EPHB2 RANBP9 23118896 2711943 Negative_regulation EPHB2 RANBP9 23118896 2711978 Negative_regulation EPHB2 RANBP9 23118896 2711979 Negative_regulation EPHB2 RANBP9 23118896 2712009 Negative_regulation EPHB2 RANBP9 23118896 2712026 Negative_regulation EPHB2 RANBP9 23118896 2712041 Negative_regulation EPHB2 RASA1 23133361 2297653 Negative_regulation EPHB2 RASGRP1 22719950 2653878 Negative_regulation EPHB2 RASGRP1 22719950 2653887 Negative_regulation EPHB2 RASGRP3 24779681 1874133 Negative_regulation EPHB2 RASGRP3 24779681 1874134 Negative_regulation EPHB2 RASSF1 17692468 157413 Negative_regulation EPHB2 RBBP4 23166712 2718715 Negative_regulation EPHB2 RBBP7 23166712 2718716 Negative_regulation EPHB2 REL 20562914 2132684 Negative_regulation EPHB2 REL 20562914 2132731 Negative_regulation EPHB2 RET 15769183 2257990 Negative_regulation EPHB2 RET 21847121 437662 Negative_regulation EPHB2 RET 22941289 15977 Negative_regulation EPHB2 RGS16 16012519 426301 Negative_regulation EPHB2 RGS16 19636436 1671447 Negative_regulation EPHB2 RGS2 24743392 2955274 Negative_regulation EPHB2 RGS2 24743392 2955275 Negative_regulation EPHB2 RGS2 24743392 2955427 Negative_regulation EPHB2 RGS2 24743392 2955456 Negative_regulation EPHB2 RGS4 24743392 2955272 Negative_regulation EPHB2 RGS4 24743392 2955273 Negative_regulation EPHB2 RGS4 24743392 2955426 Negative_regulation EPHB2 RGS4 24743392 2955455 Negative_regulation EPHB2 RGS9 21852966 933497 Negative_regulation EPHB2 RHOA 21731751 2532423 Negative_regulation EPHB2 RHOA 24478700 858780 Negative_regulation EPHB2 RHOA 24478700 858781 Negative_regulation EPHB2 RHOA 24478700 858782 Negative_regulation EPHB2 RHOA 24478700 858789 Negative_regulation EPHB2 RHOA 24478700 858790 Negative_regulation EPHB2 RHOC 15969750 1844734 Negative_regulation EPHB2 RNF19A 21569377 1658372 Negative_regulation EPHB2 RNF19A 22563433 2626514 Negative_regulation EPHB2 RNF19A 22675451 2648408 Negative_regulation EPHB2 RNF19A 23060802 959338 Negative_regulation EPHB2 RNF19A 23277279 610806 Negative_regulation EPHB2 RNF19A 23577223 2225778 Negative_regulation EPHB2 RNF19A 25423094 3029895 Negative_regulation EPHB2 RNPEP 24748172 2956024 Negative_regulation EPHB2 ROCK1 22348054 2596679 Negative_regulation EPHB2 ROCK1 24091658 566672 Negative_regulation EPHB2 ROCK1 25538140 1905524 Negative_regulation EPHB2 ROCK2 22348054 2596680 Negative_regulation EPHB2 ROCK2 24091658 566673 Negative_regulation EPHB2 ROCK2 25538140 1905525 Negative_regulation EPHB2 RPGR 24672654 1024322 Negative_regulation EPHB2 RPL17 19783989 1953238 Negative_regulation EPHB2 RPL17 21408177 2507170 Negative_regulation EPHB2 RPS29 23237212 625263 Negative_regulation EPHB2 RPS3 21738525 922781 Negative_regulation EPHB2 RPTOR 21278786 2137802 Negative_regulation EPHB2 RPTOR 22668349 212844 Negative_regulation EPHB2 RPTOR 23437362 2756627 Negative_regulation EPHB2 RPTOR 24212820 498647 Negative_regulation EPHB2 RPTOR 24212820 498786 Negative_regulation EPHB2 RPTOR 24393708 2186575 Negative_regulation EPHB2 RRAS 24705357 1034808 Negative_regulation EPHB2 RUNX2 24531206 795213 Negative_regulation EPHB2 RYR2 25093823 2995353 Negative_regulation EPHB2 SAP18 23166712 2718710 Negative_regulation EPHB2 SAP30 23166712 2718711 Negative_regulation EPHB2 SEC13 23342042 2741712 Negative_regulation EPHB2 SEC62 23342042 2741713 Negative_regulation EPHB2 SEC63 23342042 2741714 Negative_regulation EPHB2 SELP 20977756 379588 Negative_regulation EPHB2 SERPINF1 24763086 2958126 Negative_regulation EPHB2 SETD2 23869238 2821187 Negative_regulation EPHB2 SFN 20642839 1647347 Negative_regulation EPHB2 SHC1 22020565 809892 Negative_regulation EPHB2 SHC1 23237212 625264 Negative_regulation EPHB2 SHOC2 22606262 2642604 Negative_regulation EPHB2 SHOC2 25514808 3034798 Negative_regulation EPHB2 SIN3A 23166712 2718712 Negative_regulation EPHB2 SIRPA 21886829 2547835 Negative_regulation EPHB2 SIRT1 22269797 1898903 Negative_regulation EPHB2 SKAP1 18320039 2384870 Negative_regulation EPHB2 SKP1 23709168 96673 Negative_regulation EPHB2 SLC12A9 16879721 1163602 Negative_regulation EPHB2 SLC33A1 23155382 2716979 Negative_regulation EPHB2 SLC33A1 23243430 816468 Negative_regulation EPHB2 SLC39A9 23505453 2766084 Negative_regulation EPHB2 SLC4A1 24842369 1576322 Negative_regulation EPHB2 SLC6A4 20439996 1375975 Negative_regulation EPHB2 SLC7A11 20100173 212579 Negative_regulation EPHB2 SLC9A1 22904641 490813 Negative_regulation EPHB2 SLCO3A1 24945726 2981562 Negative_regulation EPHB2 SLCO6A1 23318582 611035 Negative_regulation EPHB2 SLCO6A1 23318582 611040 Negative_regulation EPHB2 SMAD1 22614218 2170898 Negative_regulation EPHB2 SMAD2 22614218 2170899 Negative_regulation EPHB2 SMAD2 24533426 1636603 Negative_regulation EPHB2 SMAD3 22614218 2170900 Negative_regulation EPHB2 SMAD3 24533426 1636604 Negative_regulation EPHB2 SMAD4 20712893 1858038 Negative_regulation EPHB2 SMAD4 20712893 1858095 Negative_regulation EPHB2 SMAD4 22614218 2170901 Negative_regulation EPHB2 SMAD5 22614218 2170902 Negative_regulation EPHB2 SMAD6 22614218 2170903 Negative_regulation EPHB2 SMAD7 22614218 2170904 Negative_regulation EPHB2 SMAD9 22614218 2170905 Negative_regulation EPHB2 SMARCA2 24811485 2190629 Negative_regulation EPHB2 SMARCA4 24811485 2190630 Negative_regulation EPHB2 SMARCA4 24811485 2190926 Negative_regulation EPHB2 SMARCB1 24811485 2190631 Negative_regulation EPHB2 SMARCB1 24811485 2190927 Negative_regulation EPHB2 SMARCC1 24811485 2190632 Negative_regulation EPHB2 SMARCC1 24811485 2190928 Negative_regulation EPHB2 SMARCC2 24811485 2190633 Negative_regulation EPHB2 SMARCC2 24811485 2190929 Negative_regulation EPHB2 SMARCD1 24811485 2190634 Negative_regulation EPHB2 SMARCD1 24811485 2190930 Negative_regulation EPHB2 SMARCD2 24811485 2190931 Negative_regulation EPHB2 SMARCE1 24811485 2190635 Negative_regulation EPHB2 SMARCE1 24811485 2190932 Negative_regulation EPHB2 SMURF1 22396737 2608343 Negative_regulation EPHB2 SMURF2 22396737 2608344 Negative_regulation EPHB2 SNTG1 22945933 1399935 Negative_regulation EPHB2 SOAT1 22649371 874827 Negative_regulation EPHB2 SOCS1 12010564 98733 Negative_regulation EPHB2 SOCS3 21124310 1918082 Negative_regulation EPHB2 SOCS3 24260222 2882858 Negative_regulation EPHB2 SOD1 15123736 1308399 Negative_regulation EPHB2 SOD2 15123736 1308400 Negative_regulation EPHB2 SOD3 15123736 1308401 Negative_regulation EPHB2 SOS1 25397617 3027234 Negative_regulation EPHB2 SOX2 22885405 218167 Negative_regulation EPHB2 SOX9 22207314 30166 Negative_regulation EPHB2 SPHK1 24917786 931954 Negative_regulation EPHB2 SPHK1 24970177 208764 Negative_regulation EPHB2 SPHK2 24917786 931955 Negative_regulation EPHB2 SPP1 20868520 1859576 Negative_regulation EPHB2 SPP1 21406114 286551 Negative_regulation EPHB2 SPRED1 21364986 2504721 Negative_regulation EPHB2 SPRED2 14981116 1531627 Negative_regulation EPHB2 SPRED2 23169297 439639 Negative_regulation EPHB2 SPRED2 24099000 367271 Negative_regulation EPHB2 SPRY1 20813052 1858427 Negative_regulation EPHB2 SPRY1 21483770 2512056 Negative_regulation EPHB2 SPRY1 21483770 2512057 Negative_regulation EPHB2 SPRY1 21483770 2512062 Negative_regulation EPHB2 SPRY1 21709278 719553 Negative_regulation EPHB2 SPRY1 23469214 2763283 Negative_regulation EPHB2 SPRY1 24932220 1679395 Negative_regulation EPHB2 SPRY1 24932220 1679403 Negative_regulation EPHB2 SPRY1 24932220 1679407 Negative_regulation EPHB2 SPRY2 18335055 2387107 Negative_regulation EPHB2 SPRY2 18335055 2387125 Negative_regulation EPHB2 SPRY2 20459789 303955 Negative_regulation EPHB2 SPRY2 20813052 1858428 Negative_regulation EPHB2 SPRY2 21483770 2512058 Negative_regulation EPHB2 SPRY2 21909357 2550615 Negative_regulation EPHB2 SPRY2 24744103 494574 Negative_regulation EPHB2 SPRY2 24744103 494575 Negative_regulation EPHB2 SPRY2 24744103 494647 Negative_regulation EPHB2 SPRY2 24744103 494648 Negative_regulation EPHB2 SPRY2 24744103 494812 Negative_regulation EPHB2 SPRY2 24744103 494838 Negative_regulation EPHB2 SPRY2 24744103 494890 Negative_regulation EPHB2 SPRY3 20813052 1858429 Negative_regulation EPHB2 SPRY3 21483770 2512059 Negative_regulation EPHB2 SPRY4 20813052 1858430 Negative_regulation EPHB2 SPRY4 21483770 2512060 Negative_regulation EPHB2 SPRY4 23554919 2773773 Negative_regulation EPHB2 SPRY4 23554919 2773833 Negative_regulation EPHB2 SPRY4 23554919 2773867 Negative_regulation EPHB2 SPRY4 23554919 2773970 Negative_regulation EPHB2 SPRY4 23554919 2774041 Negative_regulation EPHB2 SPRY4 24744103 494649 Negative_regulation EPHB2 SPRY4 24744103 494813 Negative_regulation EPHB2 SRC 11897012 389920 Negative_regulation EPHB2 SRC 19152120 1478464 Negative_regulation EPHB2 SRC 19357636 1902987 Negative_regulation EPHB2 SRC 19602257 385592 Negative_regulation EPHB2 SRC 22675459 2648690 Negative_regulation EPHB2 SRC 23009336 1866971 Negative_regulation EPHB2 SRC 23601194 536010 Negative_regulation EPHB2 SRC 24839453 825907 Negative_regulation EPHB2 SREBF1 23153363 1725119 Negative_regulation EPHB2 SST 25009500 965393 Negative_regulation EPHB2 SSTR1 21589940 2523404 Negative_regulation EPHB2 SSTR5 25009500 965394 Negative_regulation EPHB2 STAB2 24586357 2924401 Negative_regulation EPHB2 STAB2 24586357 2924404 Negative_regulation EPHB2 STAT1 20861313 1783194 Negative_regulation EPHB2 STAT1 23741352 2800465 Negative_regulation EPHB2 STAT3 21625731 1161933 Negative_regulation EPHB2 STAT3 21871133 1863068 Negative_regulation EPHB2 STAT3 21871133 1863081 Negative_regulation EPHB2 STAT3 21909139 2142564 Negative_regulation EPHB2 STAT3 23781121 1753378 Negative_regulation EPHB2 STAT3 24288470 3155216 Negative_regulation EPHB2 STAT6 22032493 366657 Negative_regulation EPHB2 STIM1 24586666 2926122 Negative_regulation EPHB2 STS 23303125 558812 Negative_regulation EPHB2 SULF2 20707913 257090 Negative_regulation EPHB2 SULF2 20707913 257091 Negative_regulation EPHB2 SYK 22883599 292363 Negative_regulation EPHB2 TAAR6 22028782 2564193 Negative_regulation EPHB2 TAB2 22396737 2608345 Negative_regulation EPHB2 TACSTD2 22419550 778542 Negative_regulation EPHB2 TAT 24499258 34936 Negative_regulation EPHB2 TBC1D10C 23109291 779257 Negative_regulation EPHB2 TBC1D10C 23109291 779258 Negative_regulation EPHB2 TBC1D10C 23109291 779270 Negative_regulation EPHB2 TBX22 21217783 2137340 Negative_regulation EPHB2 TCF19 25211343 3006924 Negative_regulation EPHB2 TCL1B 24722758 2951639 Negative_regulation EPHB2 TDGF1P3 23133361 2297649 Negative_regulation EPHB2 TDGF1P3 23133361 2297666 Negative_regulation EPHB2 TDGF1P3 23133361 2297698 Negative_regulation EPHB2 TERF1 23360994 1934895 Negative_regulation EPHB2 TERF2 23360994 1934896 Negative_regulation EPHB2 TERF2IP 23360994 1934899 Negative_regulation EPHB2 TFPI 23508943 906536 Negative_regulation EPHB2 THEMIS 21189249 1190235 Negative_regulation EPHB2 THEMIS 24586531 2925380 Negative_regulation EPHB2 TIAF1 22534828 555441 Negative_regulation EPHB2 TIMP3 25226613 2199956 Negative_regulation EPHB2 TINF2 23360994 1934897 Negative_regulation EPHB2 TMED7 19015320 1361431 Negative_regulation EPHB2 TMED7 25412313 579219 Negative_regulation EPHB2 TNF 16207331 104233 Negative_regulation EPHB2 TNF 16207331 104265 Negative_regulation EPHB2 TNF 20802503 11718 Negative_regulation EPHB2 TNF 23800251 1627045 Negative_regulation EPHB2 TNF 24789665 1886419 Negative_regulation EPHB2 TNF 25593642 206980 Negative_regulation EPHB2 TNFAIP6 25088370 1668373 Negative_regulation EPHB2 TNFAIP6 25088370 1668439 Negative_regulation EPHB2 TNFRSF1B 25010044 2987695 Negative_regulation EPHB2 TNFRSF6B 22648407 1203399 Negative_regulation EPHB2 TNFRSF6B 22648407 1203466 Negative_regulation EPHB2 TNFSF11 24244809 204678 Negative_regulation EPHB2 TNFSF11 24244809 204706 Negative_regulation EPHB2 TNMD 18931684 1960464 Negative_regulation EPHB2 TP53 20421909 3176956 Negative_regulation EPHB2 TP53 20727231 466208 Negative_regulation EPHB2 TP53 25068118 3167135 Negative_regulation EPHB2 TRAF1 9432981 1602394 Negative_regulation EPHB2 TRAF1 9432981 1602460 Negative_regulation EPHB2 TRAF2 9432981 1602395 Negative_regulation EPHB2 TRAF2 9432981 1602461 Negative_regulation EPHB2 TRAF2 9432981 1602480 Negative_regulation EPHB2 TRAF3 24378539 1574369 Negative_regulation EPHB2 TRAF3 9432981 1602396 Negative_regulation EPHB2 TRAF3 9432981 1602462 Negative_regulation EPHB2 TRAF4 9432981 1602397 Negative_regulation EPHB2 TRAF4 9432981 1602463 Negative_regulation EPHB2 TRAF5 9432981 1602398 Negative_regulation EPHB2 TRAF5 9432981 1602464 Negative_regulation EPHB2 TRAF6 22396737 2608341 Negative_regulation EPHB2 TRAF6 9432981 1602399 Negative_regulation EPHB2 TRAF6 9432981 1602465 Negative_regulation EPHB2 TRAF7 9432981 1602400 Negative_regulation EPHB2 TRAF7 9432981 1602466 Negative_regulation EPHB2 TREM2 21861861 123783 Negative_regulation EPHB2 TRIB1 20406432 328836 Negative_regulation EPHB2 TRIB2 18952906 1051095 Negative_regulation EPHB2 TRPC5 19680266 546154 Negative_regulation EPHB2 TRPM7 24223965 2877505 Negative_regulation EPHB2 TSC22D3 22396737 2608325 Negative_regulation EPHB2 TSC22D3 25100999 954731 Negative_regulation EPHB2 TSC22D3 25100999 954774 Negative_regulation EPHB2 UBE2V1 22396737 2608342 Negative_regulation EPHB2 UBIAD1 23119142 518836 Negative_regulation EPHB2 UTS2R 20859543 3208905 Negative_regulation EPHB2 VAV1 11413196 1519512 Negative_regulation EPHB2 VAV1 25313137 2205098 Negative_regulation EPHB2 VAV3 23566222 1867793 Negative_regulation EPHB2 VEGFA 21505453 436717 Negative_regulation EPHB2 VEGFA 25268615 1131235 Negative_regulation EPHB2 VEGFA 9832563 1472166 Negative_regulation EPHB2 VEGFA 9832563 1472167 Negative_regulation EPHB2 VEGFC 23344023 1100625 Negative_regulation EPHB2 VIP 23549262 1104634 Negative_regulation EPHB2 VLDLR 11266465 1269091 Negative_regulation EPHB2 VTCN1 22238573 2586549 Negative_regulation EPHB2 VTN 23507864 179110 Negative_regulation EPHB2 WNK1 23573134 818426 Negative_regulation EPHB2 WNK1 23573134 818427 Negative_regulation EPHB2 WNK1 24929539 1234223 Negative_regulation EPHB2 WNT1 14979908 458221 Negative_regulation EPHB2 WNT1 20828404 1858759 Negative_regulation EPHB2 WNT1 22200028 2115841 Negative_regulation EPHB2 WNT1 22701736 2652414 Negative_regulation EPHB2 WNT11 22200028 2115842 Negative_regulation EPHB2 WNT11 22701736 2652415 Negative_regulation EPHB2 WNT16 22200028 2115847 Negative_regulation EPHB2 WNT16 22701736 2652420 Negative_regulation EPHB2 WNT2 22200028 2115843 Negative_regulation EPHB2 WNT2 22701736 2652416 Negative_regulation EPHB2 WNT3 22200028 2115844 Negative_regulation EPHB2 WNT3 22701736 2652417 Negative_regulation EPHB2 WNT4 22200028 2115845 Negative_regulation EPHB2 WNT4 22701736 2652418 Negative_regulation EPHB2 WNT5A 14979908 458222 Negative_regulation EPHB2 WNT5A 20828404 1858760 Negative_regulation EPHB2 WNT6 22200028 2115846 Negative_regulation EPHB2 WNT6 22701736 2652419 Negative_regulation EPHB2 ZC3H12A 24336080 570351 Negative_regulation EPHB2 ZFP1 24550733 2356816 Negative_regulation EPHB2 ZFP14 24550733 2356822 Negative_regulation EPHB2 ZFP2 24550733 2356819 Negative_regulation EPHB2 ZFP28 24550733 2356813 Negative_regulation EPHB2 ZFP3 24550733 2356807 Negative_regulation EPHB2 ZFP30 24550733 2356823 Negative_regulation EPHB2 ZFP36 24550733 2356808 Negative_regulation EPHB2 ZFP37 24550733 2356809 Negative_regulation EPHB2 ZFP41 24550733 2356820 Negative_regulation EPHB2 ZFP42 24550733 2356824 Negative_regulation EPHB2 ZFP57 24550733 2356814 Negative_regulation EPHB2 ZFP62 24550733 2356815 Negative_regulation EPHB2 ZFP64 24550733 2356812 Negative_regulation EPHB2 ZFP69 24550733 2356818 Negative_regulation EPHB2 ZFP82 24550733 2356821 Negative_regulation EPHB2 ZFP90 24550733 2356817 Negative_regulation EPHB2 ZFP91 24550733 2356811 Negative_regulation EPHB2 ZFP92 24550733 2356810 Negative_regulation EPHB2 ZGLP1 22412973 2609919 Negative_regulation EPHB2 ZIC1 22799764 265182 Negative_regulation EPHB2 ZRSR2 24587311 2929282 Negative_regulation EPHB2 ZYX 22456508 1801501 Negative_regulation EPHB6 TNF 24066693 269789 Negative_regulation EPO EPHB2 24493804 1574908 Negative_regulation EPO TNF 22094132 1768513 Negative_regulation EPO TNF 23472188 2764404 Negative_regulation EPS15 CTGF 25384022 3024586 Negative_regulation EPS15 RGS2 20135898 734800 Negative_regulation EPS8 CTGF 25384022 3024588 Negative_regulation EPS8 RGS2 20135898 734801 Negative_regulation EPX EGLN3 25392999 3025359 Negative_regulation EPX TNF 12793888 658483 Negative_regulation ERBB2 EPHB2 10648571 1255628 Negative_regulation ERBB2 EPHB2 18004277 1902447 Negative_regulation ERBB2 EPHB2 19855434 2127730 Negative_regulation ERBB2 EPHB2 22549178 438725 Negative_regulation ERCC1 FAS 20470393 1504193 Negative_regulation ERCC1 FAS 20470393 1504195 Negative_regulation ERCC1 FAS 20470393 1504196 Negative_regulation ERF MAP2K6 23509960 1666138 Negative_regulation ERG TNF 19460151 1625334 Negative_regulation ERVK-6 ANKRD1 24167575 2872139 Negative_regulation ERVK-6 CST6 10952775 417681 Negative_regulation ERVK-6 CST6 22802712 989703 Negative_regulation ERVK-6 CST6 22822455 3184073 Negative_regulation ERVK-6 MMP28 22414301 1675675 Negative_regulation ERVK-6 MMP7 22414301 1675690 Negative_regulation ERVK-6 MUC16 16817968 232088 Negative_regulation ERVK-6 TFPI2 17352822 1846263 Negative_regulation ERVK-6 TFPI2 19936309 1910106 Negative_regulation ERVK-6 TGM2 19584914 2421011 Negative_regulation ERVK-6 TNF 20690420 1142921 Negative_regulation ESD EPHB2 24710192 986316 Negative_regulation ESR1 KLF9 18783612 3096695 Negative_regulation ESR1 SPHK1 25153718 2198616 Negative_regulation ESRRA PGC 24904222 491418 Negative_regulation ETS1 CCND1 23383271 2749837 Negative_regulation ETS1 EPHB2 25203554 3006418 Negative_regulation ETS1 ID1 25009645 2169040 Negative_regulation ETS1 MAP2K6 25294825 2105138 Negative_regulation ETS1 SPHK1 21936950 1697757 Negative_regulation ETS2 EPHB2 25203554 3006419 Negative_regulation ETS2 ID1 25009645 2169041 Negative_regulation ETV7 CDH1 23029494 2698468 Negative_regulation ETV7 FANCA 25428364 2106754 Negative_regulation ETV7 FANCB 25428364 2106755 Negative_regulation ETV7 FANCC 25428364 2106756 Negative_regulation ETV7 FANCE 25428364 2106757 Negative_regulation ETV7 FANCF 25428364 2106758 Negative_regulation ETV7 FANCG 25428364 2106759 Negative_regulation ETV7 FANCM 25428364 2106753 Negative_regulation ETV7 MED15 22291956 2591520 Negative_regulation EXOSC10 TNF 21569625 1723647 Negative_regulation EXOSC10 TNF 24086143 2350901 Negative_regulation EXOSC2 TNF 21569625 1723640 Negative_regulation EXOSC2 TNF 24086143 2350886 Negative_regulation EXOSC4 TNF 21569625 1723642 Negative_regulation EXOSC4 TNF 24086143 2350890 Negative_regulation EZH2 CDKN1C 19340297 2411502 Negative_regulation EZH2 H3F3A 24894482 6109 Negative_regulation EZR CAPN8 22073041 923729 Negative_regulation EZR CAPN8 9566966 1467193 Negative_regulation EZR CAPN8 9566966 1467305 Negative_regulation F2R AHSA1 21029417 354060 Negative_regulation F2R APC 21834973 659979 Negative_regulation F2R CA2 8383691 1447822 Negative_regulation F2R EPHB2 20855497 1560236 Negative_regulation F2R F2RL3 24876677 1758983 Negative_regulation F2R HGF 24876677 1758973 Negative_regulation F2R HMGB1 24152910 220926 Negative_regulation F2R IL1A 16808851 1654916 Negative_regulation F2R IL4 21941675 1082214 Negative_regulation F2R MAPK3 21029417 354061 Negative_regulation F2R PTX3 24743392 2955400 Negative_regulation F2R PTX4 24743392 2955399 Negative_regulation F2R RGS2 24743392 2955255 Negative_regulation F2R RGS2 24743392 2955256 Negative_regulation F2R RGS2 24743392 2955266 Negative_regulation F2R RGS2 24743392 2955277 Negative_regulation F2R RGS2 24743392 2955484 Negative_regulation F2R RGS4 24743392 2955253 Negative_regulation F2R RGS4 24743392 2955254 Negative_regulation F2R RGS4 24743392 2955265 Negative_regulation F2R RGS4 24743392 2955276 Negative_regulation F2R RGS4 24743392 2955483 Negative_regulation F2R S100A8 20855497 1560235 Negative_regulation F2R S100A8 21747810 923205 Negative_regulation F2R TFAP2A 20936327 494131 Negative_regulation F2R TFPI 23320987 1617676 Negative_regulation F2R TNF 24453410 1756643 Negative_regulation F2R TXNDC17 8383691 1447816 Negative_regulation F2RL1 CTGF 19852794 1227671 Negative_regulation F2RL1 CTGF 19852794 1227759 Negative_regulation F2RL1 CTGF 19852794 1227767 Negative_regulation F2RL1 CTGF 19852794 1227771 Negative_regulation F2RL1 PLAU 23905544 473629 Negative_regulation F2RL1 TNF 24534191 1575075 Negative_regulation F2RL2 TNF 21667320 3211476 Negative_regulation F2RL3 F2R 24876677 1758984 Negative_regulation F3 ANXA5 22970290 2688051 Negative_regulation F3 CPB1 24717423 219410 Negative_regulation F3 CPB2 24717423 219411 Negative_regulation F3 SERPINB2 23826213 2811549 Negative_regulation F3 TFPI 20140262 2440294 Negative_regulation F7 TFPI2 18053161 370956 Negative_regulation F8 HES2 18218122 308341 Negative_regulation FABP4 TNF 19925655 327031 Negative_regulation FABP4 TNF 21093321 1040298 Negative_regulation FAH TNF 1989668 433967 Negative_regulation FAIM2 EPHB2 23029562 2698814 Negative_regulation FAM132A KLF9 PMC3717835 728954 Negative_regulation FANCA ETV7 25428364 2106763 Negative_regulation FANCB ETV7 25428364 2106766 Negative_regulation FANCC ETV7 25428364 2106769 Negative_regulation FANCE ETV7 25428364 2106772 Negative_regulation FANCF ETV7 25428364 2106775 Negative_regulation FANCG ETV7 25428364 2106778 Negative_regulation FANCM ETV7 25428364 2106760 Negative_regulation FAP MYH16 20223042 1029777 Negative_regulation FAP MYH3 20223042 1029784 Negative_regulation FAS ACACA 23770982 17947 Negative_regulation FAS ADIPOQ 24194895 2872567 Negative_regulation FAS AKT1 11457886 1519825 Negative_regulation FAS AKT1 18782442 111161 Negative_regulation FAS AKT1 19936232 2431762 Negative_regulation FAS AKT1 19936232 2431763 Negative_regulation FAS AKT1 19936232 2431777 Negative_regulation FAS AKT1 19936232 2431793 Negative_regulation FAS AKT1 22949843 1098054 Negative_regulation FAS AKT1 24894151 1874887 Negative_regulation FAS AKT1 24999379 2229536 Negative_regulation FAS AKT2 18782442 111162 Negative_regulation FAS AKT2 19936232 2431764 Negative_regulation FAS AKT2 19936232 2431765 Negative_regulation FAS AKT2 19936232 2431778 Negative_regulation FAS AKT2 19936232 2431794 Negative_regulation FAS AKT2 24894151 1874888 Negative_regulation FAS AKT2 24999379 2229537 Negative_regulation FAS AKT3 18782442 111163 Negative_regulation FAS AKT3 19936232 2431766 Negative_regulation FAS AKT3 19936232 2431767 Negative_regulation FAS AKT3 19936232 2431779 Negative_regulation FAS AKT3 19936232 2431795 Negative_regulation FAS AKT3 24894151 1874889 Negative_regulation FAS AKT3 24999379 2229538 Negative_regulation FAS ARHGEF2 25107365 1488247 Negative_regulation FAS ARHGEF2 25107365 1488248 Negative_regulation FAS BCL2 22087285 2571233 Negative_regulation FAS BCL2 22175008 1669857 Negative_regulation FAS BCL2 23019424 636975 Negative_regulation FAS BCL2L1 25049998 136715 Negative_regulation FAS BCL6 12860928 1527835 Negative_regulation FAS BHLHE40 18838394 2036774 Negative_regulation FAS BHLHE40 18838394 2036784 Negative_regulation FAS BHLHE41 18838394 2036706 Negative_regulation FAS BHLHE41 18838394 2036775 Negative_regulation FAS BIRC5 25049998 136714 Negative_regulation FAS BRD1 21750715 2535011 Negative_regulation FAS BRD1 21750715 2535034 Negative_regulation FAS BRPF1 21750715 2535013 Negative_regulation FAS BRPF1 21750715 2535036 Negative_regulation FAS BRPF3 21750715 2535014 Negative_regulation FAS BRPF3 21750715 2535037 Negative_regulation FAS CASP1 10893264 1259817 Negative_regulation FAS CASP1 15699214 1317860 Negative_regulation FAS CASP1 9730893 1603550 Negative_regulation FAS CASP1 9730893 1603563 Negative_regulation FAS CASP10 10893264 1259818 Negative_regulation FAS CASP10 15699214 1317861 Negative_regulation FAS CASP10 21049020 2480429 Negative_regulation FAS CASP10 21368896 551249 Negative_regulation FAS CASP10 9730893 1603551 Negative_regulation FAS CASP10 9730893 1603564 Negative_regulation FAS CASP12 10893264 1259828 Negative_regulation FAS CASP12 15699214 1317871 Negative_regulation FAS CASP12 9730893 1603561 Negative_regulation FAS CASP12 9730893 1603574 Negative_regulation FAS CASP14 10893264 1259819 Negative_regulation FAS CASP14 15699214 1317862 Negative_regulation FAS CASP14 9730893 1603552 Negative_regulation FAS CASP14 9730893 1603565 Negative_regulation FAS CASP16 10893264 1259829 Negative_regulation FAS CASP16 15699214 1317872 Negative_regulation FAS CASP16 9730893 1603562 Negative_regulation FAS CASP16 9730893 1603575 Negative_regulation FAS CASP2 10893264 1259820 Negative_regulation FAS CASP2 15699214 1317863 Negative_regulation FAS CASP2 9730893 1603553 Negative_regulation FAS CASP2 9730893 1603566 Negative_regulation FAS CASP3 10893264 1259821 Negative_regulation FAS CASP3 15699214 1317864 Negative_regulation FAS CASP3 20212524 1903517 Negative_regulation FAS CASP3 9730893 1603554 Negative_regulation FAS CASP3 9730893 1603567 Negative_regulation FAS CASP4 10893264 1259822 Negative_regulation FAS CASP4 15699214 1317865 Negative_regulation FAS CASP4 9730893 1603555 Negative_regulation FAS CASP4 9730893 1603568 Negative_regulation FAS CASP5 10893264 1259823 Negative_regulation FAS CASP5 15699214 1317866 Negative_regulation FAS CASP5 9730893 1603556 Negative_regulation FAS CASP5 9730893 1603569 Negative_regulation FAS CASP6 10893264 1259824 Negative_regulation FAS CASP6 15699214 1317867 Negative_regulation FAS CASP6 9730893 1603557 Negative_regulation FAS CASP6 9730893 1603570 Negative_regulation FAS CASP7 10893264 1259825 Negative_regulation FAS CASP7 15699214 1317868 Negative_regulation FAS CASP7 9730893 1603558 Negative_regulation FAS CASP7 9730893 1603571 Negative_regulation FAS CASP8 10893264 1259826 Negative_regulation FAS CASP8 15699214 1317869 Negative_regulation FAS CASP8 9730893 1603559 Negative_regulation FAS CASP8 9730893 1603572 Negative_regulation FAS CASP9 10893264 1259827 Negative_regulation FAS CASP9 15699214 1317870 Negative_regulation FAS CASP9 9730893 1603560 Negative_regulation FAS CASP9 9730893 1603573 Negative_regulation FAS CAT 23762486 2803687 Negative_regulation FAS CBL 23349502 725966 Negative_regulation FAS CCL21 15265234 380703 Negative_regulation FAS CD28 20815894 1504473 Negative_regulation FAS CD40 17225862 2374550 Negative_regulation FAS CD40 25117071 3205390 Negative_regulation FAS CD40 7595225 1590949 Negative_regulation FAS CD40 9683298 447471 Negative_regulation FAS CD40LG 9683298 447462 Negative_regulation FAS CD74 25304249 1510819 Negative_regulation FAS CD74 25304249 1510832 Negative_regulation FAS CDKN1A 11870542 420568 Negative_regulation FAS CFLAR 10601365 1513786 Negative_regulation FAS CFLAR 16720015 3228765 Negative_regulation FAS CFLAR 22875006 557320 Negative_regulation FAS CFLAR 22875006 557321 Negative_regulation FAS CFLAR PMC2195999 1475378 Negative_regulation FAS CISH 24024882 316810 Negative_regulation FAS CNOT6 24469038 2154624 Negative_regulation FAS COA1 17565694 320408 Negative_regulation FAS COA1 23145054 2715510 Negative_regulation FAS COA3 17565694 320410 Negative_regulation FAS COA3 23145054 2715512 Negative_regulation FAS COA4 17565694 320409 Negative_regulation FAS COA4 23145054 2715511 Negative_regulation FAS COA5 17565694 320411 Negative_regulation FAS COA5 23145054 2715513 Negative_regulation FAS COA6 17565694 320407 Negative_regulation FAS COA6 23145054 2715509 Negative_regulation FAS CPT1A 23659636 89809 Negative_regulation FAS CR2 22848207 902718 Negative_regulation FAS CTLA4 15007096 1531885 Negative_regulation FAS CTNNB1 24494192 3093976 Negative_regulation FAS CTSC 23876229 1726227 Negative_regulation FAS CX3CL1 24694544 1125792 Negative_regulation FAS CXCR4 25196285 3224079 Negative_regulation FAS DHX58 24551250 2372446 Negative_regulation FAS DNM2 24402972 492216 Negative_regulation FAS EPHB2 22046349 2566541 Negative_regulation FAS EPO 21760888 2535926 Negative_regulation FAS ERBB2 19696947 1671491 Negative_regulation FAS FAIM 15520226 1316202 Negative_regulation FAS FAIM2 23029562 2698781 Negative_regulation FAS FAS 16316466 383093 Negative_regulation FAS FAS 22038545 5131 Negative_regulation FAS FAS 24058807 1706248 Negative_regulation FAS FAS 25310648 1131918 Negative_regulation FAS FASLG 21298033 2499374 Negative_regulation FAS FASLG 25071022 2197466 Negative_regulation FAS FASLG 25101900 3068800 Negative_regulation FAS FASLG 25310648 1131919 Negative_regulation FAS FGF21 18840786 707101 Negative_regulation FAS FLOT2 24204853 2874489 Negative_regulation FAS G6PC 23213296 3153979 Negative_regulation FAS GIT1 21695141 2529527 Negative_regulation FAS HDAC1 24025359 479032 Negative_regulation FAS HDAC1 25013383 1063196 Negative_regulation FAS HDAC2 24025359 479033 Negative_regulation FAS HDAC2 25013383 1063197 Negative_regulation FAS HRAS 22046349 2566542 Negative_regulation FAS HSPB1 18493784 3091124 Negative_regulation FAS IGF1 19091070 352525 Negative_regulation FAS IL10 19756150 2426525 Negative_regulation FAS IL18BP 22891066 903443 Negative_regulation FAS IL6 19091070 352510 Negative_regulation FAS IL7 22194871 2583109 Negative_regulation FAS ING5 21750715 2535017 Negative_regulation FAS ING5 21750715 2535040 Negative_regulation FAS INPP5D 22297297 554148 Negative_regulation FAS INS 21569294 734126 Negative_regulation FAS IRF4 12566414 1525833 Negative_regulation FAS ITIH4 25196285 3224080 Negative_regulation FAS JUN 24058807 1706249 Negative_regulation FAS KAT6A 21750715 2535012 Negative_regulation FAS KAT6A 21750715 2535035 Negative_regulation FAS KAT6B 21750715 2535016 Negative_regulation FAS KAT6B 21750715 2535039 Negative_regulation FAS KAT7 21750715 2535015 Negative_regulation FAS KAT7 21750715 2535038 Negative_regulation FAS KLF6 24324791 2891185 Negative_regulation FAS KRAS 22046349 2566543 Negative_regulation FAS LEP 19727392 2425645 Negative_regulation FAS MAPK3 24894151 1874890 Negative_regulation FAS MARCH1 23300075 1206077 Negative_regulation FAS MARCH1 23300075 1206087 Negative_regulation FAS MARCH8 23300075 1206076 Negative_regulation FAS MEAF6 21750715 2535020 Negative_regulation FAS MEAF6 21750715 2535043 Negative_regulation FAS MET 23770982 17927 Negative_regulation FAS MLST8 18776140 706717 Negative_regulation FAS MS4A1 20815894 1504474 Negative_regulation FAS MSH2 11641530 1632777 Negative_regulation FAS MSH3 11641530 1632778 Negative_regulation FAS MSH4 11641530 1632779 Negative_regulation FAS MSH5 11641530 1632780 Negative_regulation FAS MSH6 11641530 1632781 Negative_regulation FAS MTOR 18776140 706719 Negative_regulation FAS MYLIP 22733138 2147698 Negative_regulation FAS MYLIP 23242178 477794 Negative_regulation FAS MYLIP 23950995 2833150 Negative_regulation FAS MYLIP 24300912 1939728 Negative_regulation FAS MYLIP 25071842 896464 Negative_regulation FAS MYLIP 25552935 1063950 Negative_regulation FAS MYLIP 25552935 1063952 Negative_regulation FAS NDRG2 22920753 266196 Negative_regulation FAS NFE2L2 24212662 498085 Negative_regulation FAS NGF 11980919 1282315 Negative_regulation FAS NOTCH1 16542414 298687 Negative_regulation FAS NOTCH2 16542414 298688 Negative_regulation FAS NOTCH3 16542414 298689 Negative_regulation FAS NOTCH4 16542414 298690 Negative_regulation FAS NRAS 22046349 2566544 Negative_regulation FAS NSRP1 21296756 2060630 Negative_regulation FAS OSR1 24931004 1681259 Negative_regulation FAS OSR1 24931004 1681310 Negative_regulation FAS PAK1 21708980 1389654 Negative_regulation FAS PAK2 21708980 1389655 Negative_regulation FAS PAK3 21708980 1389656 Negative_regulation FAS PAK4 21708980 1389652 Negative_regulation FAS PAK6 21708980 1389653 Negative_regulation FAS PAK7 21708980 1389651 Negative_regulation FAS PARVA 19667130 1367783 Negative_regulation FAS PCBD1 22979947 406957 Negative_regulation FAS PDCD4 23990362 728550 Negative_regulation FAS PEA15 21756247 3093047 Negative_regulation FAS PHF15 21750715 2535019 Negative_regulation FAS PHF15 21750715 2535042 Negative_regulation FAS PHF16 21750715 2535018 Negative_regulation FAS PHF16 21750715 2535041 Negative_regulation FAS PHF17 21750715 2535021 Negative_regulation FAS PHF17 21750715 2535044 Negative_regulation FAS PIK3CA 19384426 668885 Negative_regulation FAS PIK3CA 19936232 2431809 Negative_regulation FAS PIK3R1 19384426 668886 Negative_regulation FAS PIK3R1 19936232 2431810 Negative_regulation FAS POU5F1 25029550 2990154 Negative_regulation FAS PRKAA1 22243683 1724409 Negative_regulation FAS PRKAA1 22355282 936812 Negative_regulation FAS PRKAA1 23770982 17920 Negative_regulation FAS PRKAA1 23770982 17948 Negative_regulation FAS PRKAA1 24490657 295713 Negative_regulation FAS PRKAA2 22243683 1724410 Negative_regulation FAS PRKAA2 22355282 936813 Negative_regulation FAS PRKAA2 23770982 17921 Negative_regulation FAS PRKAA2 23770982 17949 Negative_regulation FAS PRKAA2 24490657 295714 Negative_regulation FAS PRKAB1 22243683 1724411 Negative_regulation FAS PRKAB1 22355282 936814 Negative_regulation FAS PRKAB1 23770982 17922 Negative_regulation FAS PRKAB1 23770982 17950 Negative_regulation FAS PRKAB1 24490657 295715 Negative_regulation FAS PRKAB2 22243683 1724412 Negative_regulation FAS PRKAB2 22355282 936815 Negative_regulation FAS PRKAB2 23770982 17923 Negative_regulation FAS PRKAB2 23770982 17951 Negative_regulation FAS PRKAB2 24490657 295716 Negative_regulation FAS PRKAG1 22243683 1724413 Negative_regulation FAS PRKAG1 22355282 936816 Negative_regulation FAS PRKAG1 23770982 17924 Negative_regulation FAS PRKAG1 23770982 17952 Negative_regulation FAS PRKAG1 24490657 295717 Negative_regulation FAS PRKAG2 22243683 1724414 Negative_regulation FAS PRKAG2 22355282 936817 Negative_regulation FAS PRKAG2 23770982 17925 Negative_regulation FAS PRKAG2 23770982 17953 Negative_regulation FAS PRKAG2 24490657 295718 Negative_regulation FAS PTEN 22949843 1098055 Negative_regulation FAS PTGS2 23552603 2156267 Negative_regulation FAS PTPN1 15723702 2112223 Negative_regulation FAS PTPN11 21118992 1783631 Negative_regulation FAS PTPN13 12605713 1843475 Negative_regulation FAS QRICH1 23019424 636973 Negative_regulation FAS QRICH2 23019424 636974 Negative_regulation FAS RAB8A 25259610 3010514 Negative_regulation FAS RAF1 16365167 1326369 Negative_regulation FAS RASA1 10769036 1257239 Negative_regulation FAS RBBP4 24025359 479034 Negative_regulation FAS RBBP4 25013383 1063198 Negative_regulation FAS RBBP7 24025359 479035 Negative_regulation FAS RBBP7 25013383 1063199 Negative_regulation FAS RETN 23710116 1753139 Negative_regulation FAS RETN 23710116 1753145 Negative_regulation FAS RETN 23710116 1753148 Negative_regulation FAS RHO 22830013 1689005 Negative_regulation FAS RHO 22830013 1689008 Negative_regulation FAS RHOA 18195107 1347904 Negative_regulation FAS RPTOR 18776140 706718 Negative_regulation FAS SERPINB3 22569330 1724562 Negative_regulation FAS SETD2 18838394 2036785 Negative_regulation FAS SNAP25 9449721 1602535 Negative_regulation FAS SPN 10601365 1513785 Negative_regulation FAS SREBF1 22966071 724686 Negative_regulation FAS STAT3 24058807 1706247 Negative_regulation FAS STRA13 18838394 2036798 Negative_regulation FAS TAC1 18094751 2381472 Negative_regulation FAS TAC3 18094751 2381473 Negative_regulation FAS TAC4 18094751 2381474 Negative_regulation FAS TET1 22507896 799402 Negative_regulation FAS TET2 22507896 799401 Negative_regulation FAS TLN1 19667130 1367782 Negative_regulation FAS TNFRSF1A 21850048 552445 Negative_regulation FAS TNFRSF1B 17254331 165993 Negative_regulation FAS TNFRSF1B 17254331 166003 Negative_regulation FAS TNFRSF1B 17254331 166011 Negative_regulation FAS TP53 12923319 1634225 Negative_regulation FAS TP53 17344317 2026669 Negative_regulation FAS TP53 24904906 950064 Negative_regulation FAS TP53 9841917 1604735 Negative_regulation FAS TRIP6 16880273 1331774 Negative_regulation FAS TSC22D4 23307490 779841 Negative_regulation FAS XIAP 14609433 3095297 Negative_regulation FAS YBX1 24885403 273230 Negative_regulation FAS YY1 25053986 986826 Negative_regulation FAS ZFYVE21 23382803 2746259 Negative_regulation FAS ZMAT3 24469038 2154621 Negative_regulation FAS ZMAT3 24469038 2154622 Negative_regulation FAS ZMAT3 24469038 2154625 Negative_regulation FASLG FAS 10579724 1253150 Negative_regulation FASLG FAS 11710833 420156 Negative_regulation FASLG FAS 12119351 1524248 Negative_regulation FASLG FAS 12177809 421998 Negative_regulation FASLG FAS 15569384 382398 Negative_regulation FASLG FAS 21298033 2499375 Negative_regulation FASLG FAS 22929310 1506546 Negative_regulation FASLG FAS 23152729 745750 Negative_regulation FASLG FAS 25270871 1886673 Negative_regulation FASLG FAS 25310648 1131920 Negative_regulation FASLG FAS 8760796 1598728 Negative_regulation FASLG FOXO1 20604938 329351 Negative_regulation FASLG MMP28 7500022 1587126 Negative_regulation FASLG MMP7 19267908 385421 Negative_regulation FASLG MMP7 7500022 1587141 Negative_regulation FASLG PTGER2 18648368 430771 Negative_regulation FASLG TNF 19641635 1909323 Negative_regulation FASLG TNF 21562052 1637162 Negative_regulation FASN CCND1 22751438 541620 Negative_regulation FASN FAS 22452877 2113188 Negative_regulation FASN FOXO1 23532271 453330 Negative_regulation FASN PGC 22087241 2570699 Negative_regulation FBXO32 ACVR2B 20856813 2474793 Negative_regulation FBXO32 ACVR2B 20856813 2474800 Negative_regulation FBXO32 AKT1 24237131 664984 Negative_regulation FBXO32 AKT1 25294954 1762725 Negative_regulation FBXO32 AKT2 24237131 664985 Negative_regulation FBXO32 AKT2 25294954 1762726 Negative_regulation FBXO32 AKT3 24237131 664986 Negative_regulation FBXO32 AKT3 25294954 1762727 Negative_regulation FBXO32 ATF4 22477519 1238970 Negative_regulation FBXO32 CRTC1 24237131 665010 Negative_regulation FBXO32 FOXO1 24971321 193320 Negative_regulation FBXO32 FOXO3 22586590 722918 Negative_regulation FBXO32 FOXO3 24971321 193321 Negative_regulation FBXO32 FOXO4 24971321 193322 Negative_regulation FBXO32 FOXO6 24971321 193319 Negative_regulation FBXO32 GRAP2 23046544 3161181 Negative_regulation FBXO32 HGF 24963862 2983465 Negative_regulation FBXO32 HOXA9 23589697 2121207 Negative_regulation FBXO32 IGF1 21475698 1238364 Negative_regulation FBXO32 IGF1 22207907 1238547 Negative_regulation FBXO32 IGF1 22974011 2113487 Negative_regulation FBXO32 IGF1 23497226 2113859 Negative_regulation FBXO32 IGF1 23512346 1606782 Negative_regulation FBXO32 IGF1 25294954 1762728 Negative_regulation FBXO32 IL1A 24180744 345800 Negative_regulation FBXO32 INS 22207907 1238548 Negative_regulation FBXO32 IRS1 23762056 1073576 Negative_regulation FBXO32 JUNB 20921137 1380121 Negative_regulation FBXO32 JUNB 20921137 1380122 Negative_regulation FBXO32 JUNB 20921137 1380123 Negative_regulation FBXO32 JUNB 20921137 1380144 Negative_regulation FBXO32 JUNB 23268536 740129 Negative_regulation FBXO32 JUNB 23665154 1054172 Negative_regulation FBXO32 JUNB 23665154 1054174 Negative_regulation FBXO32 LIF 24963862 2983466 Negative_regulation FBXO32 MSTN 24718581 2950864 Negative_regulation FBXO32 MYLIP 22477519 1238969 Negative_regulation FBXO32 PGC 24478779 910962 Negative_regulation FBXO32 PGC 25375380 578988 Negative_regulation FBXO32 PIK3CA 25294954 1762729 Negative_regulation FBXO32 PIK3R1 25294954 1762730 Negative_regulation FBXO32 RNF19A 23046544 3161217 Negative_regulation FBXO32 SMAD1 24237131 665110 Negative_regulation FBXO32 SMAD2 24237131 665111 Negative_regulation FBXO32 SMAD3 24237131 665112 Negative_regulation FBXO32 SMAD4 24237131 665113 Negative_regulation FBXO32 SMAD5 24237131 665114 Negative_regulation FBXO32 SMAD6 24145169 1411657 Negative_regulation FBXO32 SMAD6 24237131 665115 Negative_regulation FBXO32 SMAD7 24237131 665116 Negative_regulation FBXO32 SMAD9 24237131 665117 Negative_regulation FBXO32 SREBF1 23226416 2724652 Negative_regulation FBXO32 TNF 23378678 3611 Negative_regulation FBXO4 CCND1 21242966 2137417 Negative_regulation FCGR3A MMP28 23424655 2755084 Negative_regulation FCGR3A MMP7 23424655 2755099 Negative_regulation FFAR1 ID1 21940780 720690 Negative_regulation FGB ITGB2 21651795 3112235 Negative_regulation FGB PLAT 24275785 2244498 Negative_regulation FGB TNF 23208413 2110598 Negative_regulation FGF1 MAP2K6 23300662 2734309 Negative_regulation FGF1 MSX1 22383889 2331880 Negative_regulation FGF1 MSX1 22383889 2332545 Negative_regulation FGF10 MAP2K6 23300662 2734316 Negative_regulation FGF10 MSX1 22383889 2331882 Negative_regulation FGF11 MAP2K6 23300662 2734323 Negative_regulation FGF11 MSX1 22383889 2331884 Negative_regulation FGF12 MAP2K6 23300662 2734330 Negative_regulation FGF12 MSX1 22383889 2331886 Negative_regulation FGF13 MAP2K6 23300662 2734337 Negative_regulation FGF13 MSX1 22383889 2331888 Negative_regulation FGF14 MAP2K6 23300662 2734344 Negative_regulation FGF14 MSX1 22383889 2331890 Negative_regulation FGF16 MAP2K6 23300662 2734351 Negative_regulation FGF16 MSX1 22383889 2331892 Negative_regulation FGF17 MAP2K6 23300662 2734358 Negative_regulation FGF17 MSX1 22383889 2331894 Negative_regulation FGF18 MAP2K6 23300662 2734365 Negative_regulation FGF18 MSX1 22383889 2331896 Negative_regulation FGF18 MSX1 22383889 2332547 Negative_regulation FGF19 MAP2K6 23300662 2734372 Negative_regulation FGF19 MSX1 22383889 2331898 Negative_regulation FGF2 CHI3L1 20540736 1656242 Negative_regulation FGF2 EDN2 23469133 2762013 Negative_regulation FGF2 EPHB2 24827991 2969921 Negative_regulation FGF2 EPHB2 24980830 2194850 Negative_regulation FGF2 IFI27 23915242 1232468 Negative_regulation FGF2 MAP2K6 22870983 288847 Negative_regulation FGF2 MAP2K6 22870983 288957 Negative_regulation FGF2 MAP2K6 23300662 2734379 Negative_regulation FGF2 MAP2K6 23919458 294631 Negative_regulation FGF2 MSX1 22383889 2331900 Negative_regulation FGF2 PLAU 20414463 1672161 Negative_regulation FGF2 TNF 19014534 2232724 Negative_regulation FGF2 TNF 19014534 2232725 Negative_regulation FGF2 TNF 19014534 2232765 Negative_regulation FGF20 MAP2K6 23300662 2734386 Negative_regulation FGF20 MSX1 22383889 2331902 Negative_regulation FGF21 MAP2K6 23300662 2734393 Negative_regulation FGF21 MSX1 22383889 2331904 Negative_regulation FGF21 MSX1 22383889 2332549 Negative_regulation FGF21 PGC 24900988 192548 Negative_regulation FGF22 MAP2K6 23300662 2734400 Negative_regulation FGF22 MSX1 22383889 2331906 Negative_regulation FGF23 MAP2K6 23300662 2734407 Negative_regulation FGF23 MSX1 22383889 2331908 Negative_regulation FGF3 MAP2K6 23300662 2734414 Negative_regulation FGF3 MSX1 22383889 2331910 Negative_regulation FGF4 MAP2K6 23300662 2734421 Negative_regulation FGF4 MSX1 22383889 2331912 Negative_regulation FGF5 MAP2K6 23300662 2734428 Negative_regulation FGF5 MSX1 22383889 2331914 Negative_regulation FGF6 MAP2K6 23300662 2734435 Negative_regulation FGF6 MSX1 22383889 2331916 Negative_regulation FGF7 MAP2K6 23300662 2734442 Negative_regulation FGF7 MSX1 22383889 2331918 Negative_regulation FGF8 MAP2K6 23300662 2734449 Negative_regulation FGF8 MSX1 22383889 2331920 Negative_regulation FGF9 MAP2K6 23300662 2734456 Negative_regulation FGF9 MSX1 22383889 2331922 Negative_regulation FGFBP1 USF1 12086590 369017 Negative_regulation FGFBP1 USF2 12086590 369018 Negative_regulation FGFR1 CCND1 21176227 3226242 Negative_regulation FGFR1 EPHB2 24980830 2194852 Negative_regulation FGFR1 KLF9 20554758 1777902 Negative_regulation FGFR1 KLF9 20554758 1777903 Negative_regulation FGFR1 KLF9 20554758 1777917 Negative_regulation FGFR2 IL1B 23867201 2183665 Negative_regulation FGFR3 ALDH2 PMC4212304 3206216 Negative_regulation FGFR3 LBP 24219868 221094 Negative_regulation FGFR3 PGC 23716639 2088919 Negative_regulation FGFR3 PGC 24466039 2912191 Negative_regulation FHL1 ELL 18611274 281578 Negative_regulation FHL1 MYLIP 25272045 3011954 Negative_regulation FHL1 MYLIP 25272045 3011959 Negative_regulation FHL1 MYLIP 25272045 3011964 Negative_regulation FHL1 MYLIP 25272045 3011966 Negative_regulation FHL1 TCEA1 18611274 281577 Negative_regulation FHL2 EPHB2 19925682 327064 Negative_regulation FLG CA2 24116231 2865890 Negative_regulation FLG CA2 7678013 1438675 Negative_regulation FLG CDKN1A 24116231 2865883 Negative_regulation FLG CDKN1B 24116231 2865884 Negative_regulation FLG EGFR 24966027 94878 Negative_regulation FLG IL13 24069552 1706776 Negative_regulation FLG IL25 23657503 1632222 Negative_regulation FLG IL25 23657503 1632223 Negative_regulation FLG IL25 23657503 1632227 Negative_regulation FLG IL25 24991450 82483 Negative_regulation FLG IL4 24069552 1706777 Negative_regulation FLG IL4 24116291 204376 Negative_regulation FLG LOR 25010647 2988000 Negative_regulation FLG MAFB 21072181 2481236 Negative_regulation FLG OSM 25010647 2987998 Negative_regulation FLG PDZK1IP1 24116291 204398 Negative_regulation FLG SOX2 21072181 2481235 Negative_regulation FLNA CAPN8 23977256 2839491 Negative_regulation FLOT2 TNF 18475742 1746192 Negative_regulation FLT3 MAP2K6 21453545 1616419 Negative_regulation FN1 ANGPT1 24459518 746248 Negative_regulation FN1 CLDN10 23752226 1572352 Negative_regulation FN1 CLU 25148511 3002013 Negative_regulation FN1 IL1B 11132772 1737235 Negative_regulation FN1 PLAU 23018346 1735697 Negative_regulation FN1 TNF 11132772 1737234 Negative_regulation FN1 TNF 19358720 659158 Negative_regulation FN1 WIF1 20573255 1856513 Negative_regulation FNDC5 PGC 24999318 869619 Negative_regulation FOLR1 CAND1 23535663 1935799 Negative_regulation FOLR1 MTOR 20069122 1671634 Negative_regulation FOLR1 PRKACB 23967182 2834754 Negative_regulation FOLR1 PRKACG 23967182 2834755 Negative_regulation FOLR1 PRKAR1A 23967182 2834756 Negative_regulation FOLR1 PRKAR1B 23967182 2834757 Negative_regulation FOLR1 PRKAR2A 23967182 2834758 Negative_regulation FOLR1 PRKAR2B 23967182 2834759 Negative_regulation FOS CLDN10 23752226 1572379 Negative_regulation FOS EPHB2 19925682 327059 Negative_regulation FOS EPHB2 23843873 821188 Negative_regulation FOS EPHB2 23946780 2165334 Negative_regulation FOS EPHB2 24386331 2903521 Negative_regulation FOS RASD1 21915321 2553256 Negative_regulation FOS TNF 24304472 1482093 Negative_regulation FOS TNF 24304472 1482128 Negative_regulation FOXA1 ARX 22570716 2631383 Negative_regulation FOXA1 ARX 22570716 2631386 Negative_regulation FOXA1 CDH1 22391567 2146661 Negative_regulation FOXA1 CTCF 21151129 1949545 Negative_regulation FOXA1 ELF5 23300383 2281199 Negative_regulation FOXA1 ELF5 25080108 607206 Negative_regulation FOXA1 FOXA2 24093963 345448 Negative_regulation FOXA1 GATA3 24339902 2894135 Negative_regulation FOXA1 HTATIP2 24853420 576131 Negative_regulation FOXA1 INS 22238690 2587081 Negative_regulation FOXA1 KMT2A 24288367 2096304 Negative_regulation FOXA1 SMAD3 18003659 2031533 Negative_regulation FOXA1 SMAD3 18003659 2031534 Negative_regulation FOXA1 SMAD3 18003659 2031561 Negative_regulation FOXA2 FOXA1 22238690 2587070 Negative_regulation FOXA2 FOXO1 22013015 720929 Negative_regulation FOXO1 AKT1 18355401 1646175 Negative_regulation FOXO1 AKT1 18665269 2394196 Negative_regulation FOXO1 AKT1 19260765 2266196 Negative_regulation FOXO1 AKT1 19593385 2421343 Negative_regulation FOXO1 AKT1 20003317 1891506 Negative_regulation FOXO1 AKT1 20585550 2314858 Negative_regulation FOXO1 AKT1 20604938 329300 Negative_regulation FOXO1 AKT1 20604938 329320 Negative_regulation FOXO1 AKT1 20642839 1647234 Negative_regulation FOXO1 AKT1 20642839 1647286 Negative_regulation FOXO1 AKT1 21144036 1647943 Negative_regulation FOXO1 AKT1 21164222 28866 Negative_regulation FOXO1 AKT1 21179458 2488105 Negative_regulation FOXO1 AKT1 21179458 2488129 Negative_regulation FOXO1 AKT1 21179458 2488141 Negative_regulation FOXO1 AKT1 21179458 2488153 Negative_regulation FOXO1 AKT1 21209957 2492638 Negative_regulation FOXO1 AKT1 21266327 717071 Negative_regulation FOXO1 AKT1 21460183 1789209 Negative_regulation FOXO1 AKT1 21464441 718976 Negative_regulation FOXO1 AKT1 21825017 1564520 Negative_regulation FOXO1 AKT1 21966641 1238490 Negative_regulation FOXO1 AKT1 21980390 2560014 Negative_regulation FOXO1 AKT1 21980390 2560153 Negative_regulation FOXO1 AKT1 22087313 2571384 Negative_regulation FOXO1 AKT1 22156377 30049 Negative_regulation FOXO1 AKT1 22312004 1395071 Negative_regulation FOXO1 AKT1 22344295 1962140 Negative_regulation FOXO1 AKT1 22344295 1962143 Negative_regulation FOXO1 AKT1 22344295 1962157 Negative_regulation FOXO1 AKT1 22344295 1962158 Negative_regulation FOXO1 AKT1 22476916 1238790 Negative_regulation FOXO1 AKT1 22690213 1073143 Negative_regulation FOXO1 AKT1 22870349 696123 Negative_regulation FOXO1 AKT1 22888331 903119 Negative_regulation FOXO1 AKT1 22891897 2113402 Negative_regulation FOXO1 AKT1 23165483 2181655 Negative_regulation FOXO1 AKT1 23392169 559423 Negative_regulation FOXO1 AKT1 23463102 773136 Negative_regulation FOXO1 AKT1 23596569 943013 Negative_regulation FOXO1 AKT1 23614736 829928 Negative_regulation FOXO1 AKT1 23630664 943099 Negative_regulation FOXO1 AKT1 23712431 1572175 Negative_regulation FOXO1 AKT1 23786484 32901 Negative_regulation FOXO1 AKT1 23800068 830084 Negative_regulation FOXO1 AKT1 23805138 907943 Negative_regulation FOXO1 AKT1 23878308 1572867 Negative_regulation FOXO1 AKT1 23995784 2153388 Negative_regulation FOXO1 AKT1 24036443 1112496 Negative_regulation FOXO1 AKT1 24062690 962233 Negative_regulation FOXO1 AKT1 24116102 2865407 Negative_regulation FOXO1 AKT1 24150286 31664 Negative_regulation FOXO1 AKT1 24237131 665093 Negative_regulation FOXO1 AKT1 24240319 1964734 Negative_regulation FOXO1 AKT1 24376685 2901817 Negative_regulation FOXO1 AKT1 24376685 2901836 Negative_regulation FOXO1 AKT1 24474938 963432 Negative_regulation FOXO1 AKT1 24600396 964302 Negative_regulation FOXO1 AKT1 24765092 912276 Negative_regulation FOXO1 AKT1 24781012 1941793 Negative_regulation FOXO1 AKT1 24806995 3172244 Negative_regulation FOXO1 AKT1 24886245 1874793 Negative_regulation FOXO1 AKT1 25045345 694445 Negative_regulation FOXO1 AKT1 25162582 3002753 Negative_regulation FOXO1 AKT1 25162582 3002863 Negative_regulation FOXO1 AKT1 25162582 3002864 Negative_regulation FOXO1 AKT1 25222566 3007464 Negative_regulation FOXO1 AKT1 25321482 578503 Negative_regulation FOXO1 AKT1 25371820 1690098 Negative_regulation FOXO1 AKT1S1 23800068 830080 Negative_regulation FOXO1 AKT2 18355401 1646176 Negative_regulation FOXO1 AKT2 19260765 2266197 Negative_regulation FOXO1 AKT2 19593385 2421344 Negative_regulation FOXO1 AKT2 20003317 1891507 Negative_regulation FOXO1 AKT2 20419126 2447043 Negative_regulation FOXO1 AKT2 20585550 2314859 Negative_regulation FOXO1 AKT2 20604938 329301 Negative_regulation FOXO1 AKT2 20604938 329321 Negative_regulation FOXO1 AKT2 20642839 1647235 Negative_regulation FOXO1 AKT2 20642839 1647287 Negative_regulation FOXO1 AKT2 21144036 1647944 Negative_regulation FOXO1 AKT2 21164222 28867 Negative_regulation FOXO1 AKT2 21179458 2488106 Negative_regulation FOXO1 AKT2 21179458 2488130 Negative_regulation FOXO1 AKT2 21179458 2488142 Negative_regulation FOXO1 AKT2 21179458 2488154 Negative_regulation FOXO1 AKT2 21209957 2492639 Negative_regulation FOXO1 AKT2 21266327 717072 Negative_regulation FOXO1 AKT2 21460183 1789210 Negative_regulation FOXO1 AKT2 21464441 718977 Negative_regulation FOXO1 AKT2 21825017 1564521 Negative_regulation FOXO1 AKT2 21966641 1238491 Negative_regulation FOXO1 AKT2 21980390 2560015 Negative_regulation FOXO1 AKT2 21980390 2560154 Negative_regulation FOXO1 AKT2 22087313 2571385 Negative_regulation FOXO1 AKT2 22156377 30050 Negative_regulation FOXO1 AKT2 22312004 1395072 Negative_regulation FOXO1 AKT2 22344295 1962141 Negative_regulation FOXO1 AKT2 22344295 1962144 Negative_regulation FOXO1 AKT2 22344295 1962159 Negative_regulation FOXO1 AKT2 22344295 1962160 Negative_regulation FOXO1 AKT2 22359667 2598706 Negative_regulation FOXO1 AKT2 22476916 1238791 Negative_regulation FOXO1 AKT2 22690213 1073144 Negative_regulation FOXO1 AKT2 22870349 696124 Negative_regulation FOXO1 AKT2 22888331 903120 Negative_regulation FOXO1 AKT2 22891897 2113403 Negative_regulation FOXO1 AKT2 23165483 2181656 Negative_regulation FOXO1 AKT2 23392169 559424 Negative_regulation FOXO1 AKT2 23463102 773137 Negative_regulation FOXO1 AKT2 23596569 943014 Negative_regulation FOXO1 AKT2 23614736 829929 Negative_regulation FOXO1 AKT2 23630664 943100 Negative_regulation FOXO1 AKT2 23712431 1572176 Negative_regulation FOXO1 AKT2 23786484 32902 Negative_regulation FOXO1 AKT2 23800068 830085 Negative_regulation FOXO1 AKT2 23805138 907944 Negative_regulation FOXO1 AKT2 23878308 1572868 Negative_regulation FOXO1 AKT2 23995784 2153389 Negative_regulation FOXO1 AKT2 24036443 1112497 Negative_regulation FOXO1 AKT2 24116102 2865408 Negative_regulation FOXO1 AKT2 24150286 31665 Negative_regulation FOXO1 AKT2 24237131 665094 Negative_regulation FOXO1 AKT2 24240319 1964735 Negative_regulation FOXO1 AKT2 24376685 2901818 Negative_regulation FOXO1 AKT2 24376685 2901837 Negative_regulation FOXO1 AKT2 24474938 963433 Negative_regulation FOXO1 AKT2 24600396 964303 Negative_regulation FOXO1 AKT2 24765092 912277 Negative_regulation FOXO1 AKT2 24781012 1941794 Negative_regulation FOXO1 AKT2 24806995 3172245 Negative_regulation FOXO1 AKT2 24886245 1874794 Negative_regulation FOXO1 AKT2 25045345 694446 Negative_regulation FOXO1 AKT2 25162582 3002754 Negative_regulation FOXO1 AKT2 25162582 3002865 Negative_regulation FOXO1 AKT2 25162582 3002866 Negative_regulation FOXO1 AKT2 25222566 3007465 Negative_regulation FOXO1 AKT2 25321482 578504 Negative_regulation FOXO1 AKT2 25371820 1690099 Negative_regulation FOXO1 AKT3 18355401 1646177 Negative_regulation FOXO1 AKT3 19260765 2266198 Negative_regulation FOXO1 AKT3 19593385 2421345 Negative_regulation FOXO1 AKT3 20003317 1891508 Negative_regulation FOXO1 AKT3 20585550 2314860 Negative_regulation FOXO1 AKT3 20604938 329302 Negative_regulation FOXO1 AKT3 20604938 329322 Negative_regulation FOXO1 AKT3 20642839 1647236 Negative_regulation FOXO1 AKT3 20642839 1647288 Negative_regulation FOXO1 AKT3 21144036 1647945 Negative_regulation FOXO1 AKT3 21164222 28868 Negative_regulation FOXO1 AKT3 21179458 2488107 Negative_regulation FOXO1 AKT3 21179458 2488131 Negative_regulation FOXO1 AKT3 21179458 2488143 Negative_regulation FOXO1 AKT3 21179458 2488155 Negative_regulation FOXO1 AKT3 21209957 2492640 Negative_regulation FOXO1 AKT3 21266327 717073 Negative_regulation FOXO1 AKT3 21460183 1789211 Negative_regulation FOXO1 AKT3 21464441 718978 Negative_regulation FOXO1 AKT3 21825017 1564522 Negative_regulation FOXO1 AKT3 21966641 1238492 Negative_regulation FOXO1 AKT3 21980390 2560016 Negative_regulation FOXO1 AKT3 21980390 2560155 Negative_regulation FOXO1 AKT3 22087313 2571386 Negative_regulation FOXO1 AKT3 22156377 30051 Negative_regulation FOXO1 AKT3 22312004 1395073 Negative_regulation FOXO1 AKT3 22344295 1962142 Negative_regulation FOXO1 AKT3 22344295 1962145 Negative_regulation FOXO1 AKT3 22344295 1962161 Negative_regulation FOXO1 AKT3 22344295 1962162 Negative_regulation FOXO1 AKT3 22476916 1238792 Negative_regulation FOXO1 AKT3 22690213 1073145 Negative_regulation FOXO1 AKT3 22870349 696125 Negative_regulation FOXO1 AKT3 22888331 903121 Negative_regulation FOXO1 AKT3 22891897 2113404 Negative_regulation FOXO1 AKT3 23165483 2181657 Negative_regulation FOXO1 AKT3 23392169 559425 Negative_regulation FOXO1 AKT3 23463102 773138 Negative_regulation FOXO1 AKT3 23596569 943015 Negative_regulation FOXO1 AKT3 23614736 829930 Negative_regulation FOXO1 AKT3 23630664 943101 Negative_regulation FOXO1 AKT3 23712431 1572177 Negative_regulation FOXO1 AKT3 23786484 32903 Negative_regulation FOXO1 AKT3 23800068 830086 Negative_regulation FOXO1 AKT3 23805138 907945 Negative_regulation FOXO1 AKT3 23878308 1572869 Negative_regulation FOXO1 AKT3 23995784 2153390 Negative_regulation FOXO1 AKT3 24036443 1112498 Negative_regulation FOXO1 AKT3 24116102 2865409 Negative_regulation FOXO1 AKT3 24150286 31666 Negative_regulation FOXO1 AKT3 24237131 665095 Negative_regulation FOXO1 AKT3 24240319 1964736 Negative_regulation FOXO1 AKT3 24376685 2901819 Negative_regulation FOXO1 AKT3 24376685 2901838 Negative_regulation FOXO1 AKT3 24474938 963434 Negative_regulation FOXO1 AKT3 24600396 964304 Negative_regulation FOXO1 AKT3 24765092 912278 Negative_regulation FOXO1 AKT3 24781012 1941795 Negative_regulation FOXO1 AKT3 24806995 3172246 Negative_regulation FOXO1 AKT3 24886245 1874795 Negative_regulation FOXO1 AKT3 25045345 694447 Negative_regulation FOXO1 AKT3 25162582 3002755 Negative_regulation FOXO1 AKT3 25162582 3002867 Negative_regulation FOXO1 AKT3 25162582 3002868 Negative_regulation FOXO1 AKT3 25222566 3007466 Negative_regulation FOXO1 AKT3 25321482 578505 Negative_regulation FOXO1 AKT3 25371820 1690100 Negative_regulation FOXO1 ANGPT1 18355401 1646233 Negative_regulation FOXO1 ANGPT1 18355401 1646241 Negative_regulation FOXO1 ARF1 23469153 2762469 Negative_regulation FOXO1 ARF3 23469153 2762470 Negative_regulation FOXO1 ARF4 23469153 2762471 Negative_regulation FOXO1 ARF5 23469153 2762472 Negative_regulation FOXO1 ARF6 23469153 2762473 Negative_regulation FOXO1 BCR 22888331 903181 Negative_regulation FOXO1 CA2 24429466 2186785 Negative_regulation FOXO1 CALM3 24429466 2186786 Negative_regulation FOXO1 CASP3 21179458 2488054 Negative_regulation FOXO1 CASP3 21179458 2488095 Negative_regulation FOXO1 CCND1 23469153 2762466 Negative_regulation FOXO1 CCND1 23469153 2762506 Negative_regulation FOXO1 CCND1 24112473 270042 Negative_regulation FOXO1 CCND2 25330112 3017215 Negative_regulation FOXO1 CD55 23786484 32900 Negative_regulation FOXO1 CD79A 22888331 903182 Negative_regulation FOXO1 CD79B 22888331 903183 Negative_regulation FOXO1 CDK1 22280365 263349 Negative_regulation FOXO1 CDK4 23469153 2762467 Negative_regulation FOXO1 CDK4 23469153 2762502 Negative_regulation FOXO1 CDKN2A 23469153 2762468 Negative_regulation FOXO1 CFTR 25299696 1131866 Negative_regulation FOXO1 CRTC2 18831768 251648 Negative_regulation FOXO1 EGF 18000534 2380604 Negative_regulation FOXO1 EGFR 24586650 2925844 Negative_regulation FOXO1 EIF4E 22476916 1238834 Negative_regulation FOXO1 ELAVL1 23946796 2165373 Negative_regulation FOXO1 ELAVL1 23946796 2165374 Negative_regulation FOXO1 EPHB2 23277279 610842 Negative_regulation FOXO1 FLI1 23995784 2153329 Negative_regulation FOXO1 FLI1 23995784 2153360 Negative_regulation FOXO1 FLI1 23995784 2153361 Negative_regulation FOXO1 FOXL2 25423188 3030084 Negative_regulation FOXO1 FOXO1 22510882 771769 Negative_regulation FOXO1 FOXO3 22510882 771770 Negative_regulation FOXO1 FOXO3 25546383 3036502 Negative_regulation FOXO1 FOXO3 25546383 3036506 Negative_regulation FOXO1 FOXO3 25546383 3036508 Negative_regulation FOXO1 FOXO4 22510882 771771 Negative_regulation FOXO1 FOXO6 22510882 771768 Negative_regulation FOXO1 FOXP3 23878131 477837 Negative_regulation FOXO1 FST 25200144 216260 Negative_regulation FOXO1 GCK 25411594 1494727 Negative_regulation FOXO1 GYS1 21335550 1190788 Negative_regulation FOXO1 GYS2 21335550 1190789 Negative_regulation FOXO1 HCFC1 24250814 2881697 Negative_regulation FOXO1 HMGN3 22399922 3158674 Negative_regulation FOXO1 HNF4A 22399922 3158675 Negative_regulation FOXO1 IGF1 19043554 2306892 Negative_regulation FOXO1 IGF1 19749979 2310860 Negative_regulation FOXO1 IGF1 19943136 25093 Negative_regulation FOXO1 IGF1 20657733 2456369 Negative_regulation FOXO1 IGF1 21990145 29896 Negative_regulation FOXO1 IGF1 21991327 2561458 Negative_regulation FOXO1 IGF1 22870349 696126 Negative_regulation FOXO1 IGF1 23620761 2783339 Negative_regulation FOXO1 IGF1R 23906066 700754 Negative_regulation FOXO1 IGF2 19043554 2306893 Negative_regulation FOXO1 IKBKE 23349709 2742994 Negative_regulation FOXO1 IL7 24765092 912279 Negative_regulation FOXO1 INS 12908874 1162986 Negative_regulation FOXO1 INS 17531095 2013446 Negative_regulation FOXO1 INS 19043554 2306894 Negative_regulation FOXO1 INS 19371409 2112515 Negative_regulation FOXO1 INS 19651810 710771 Negative_regulation FOXO1 INS 19749979 2310861 Negative_regulation FOXO1 INS 19943136 25094 Negative_regulation FOXO1 INS 20028942 712427 Negative_regulation FOXO1 INS 20185816 712939 Negative_regulation FOXO1 INS 20657733 2456370 Negative_regulation FOXO1 INS 21152033 2485838 Negative_regulation FOXO1 INS 21335550 1190783 Negative_regulation FOXO1 INS 21990145 29897 Negative_regulation FOXO1 INS 22087313 2571387 Negative_regulation FOXO1 INS 22275878 2328855 Negative_regulation FOXO1 INS 22344295 1962154 Negative_regulation FOXO1 INS 22815850 2666432 Negative_regulation FOXO1 INS 22870349 696127 Negative_regulation FOXO1 INS 23056614 2702421 Negative_regulation FOXO1 INS 23468892 2759944 Negative_regulation FOXO1 INS 23614736 829931 Negative_regulation FOXO1 INS 23885240 961966 Negative_regulation FOXO1 INS 24039594 2349760 Negative_regulation FOXO1 INS 24150286 31646 Negative_regulation FOXO1 INS 24379407 1208830 Negative_regulation FOXO1 INS 24551104 2923032 Negative_regulation FOXO1 INS 24551104 2923057 Negative_regulation FOXO1 INS 24864265 191782 Negative_regulation FOXO1 INS 24864265 191795 Negative_regulation FOXO1 INS 25299696 1131857 Negative_regulation FOXO1 INS 25299696 1131858 Negative_regulation FOXO1 INS 25501330 1135654 Negative_regulation FOXO1 INSR 18728232 706699 Negative_regulation FOXO1 INSR 19767734 1960800 Negative_regulation FOXO1 IRS1 21991327 2561413 Negative_regulation FOXO1 IRS1 21991327 2561414 Negative_regulation FOXO1 IRS1 21991327 2561415 Negative_regulation FOXO1 IRS1 24159000 728677 Negative_regulation FOXO1 IRS2 24159000 728678 Negative_regulation FOXO1 JAK2 24977668 2194639 Negative_regulation FOXO1 JAK2 24977668 2194640 Negative_regulation FOXO1 JAK2 24977668 2194674 Negative_regulation FOXO1 JUNB 20921137 1380132 Negative_regulation FOXO1 KLF7 22399922 3158676 Negative_regulation FOXO1 KRIT1 20668652 2457218 Negative_regulation FOXO1 LATS2 24525530 1940627 Negative_regulation FOXO1 LEP 23533474 817785 Negative_regulation FOXO1 LGALS4 25329053 2365556 Negative_regulation FOXO1 MAFB 22399922 3158677 Negative_regulation FOXO1 MAP2K1 18355401 1646178 Negative_regulation FOXO1 MAP2K1 20642839 1647289 Negative_regulation FOXO1 MAP2K1 21980390 2560156 Negative_regulation FOXO1 MAPK8 21164222 28879 Negative_regulation FOXO1 MAPKAP1 22891897 2113399 Negative_regulation FOXO1 MAPKAP1 23783557 2117493 Negative_regulation FOXO1 MAPKAP1 23800068 830077 Negative_regulation FOXO1 MLST8 22891897 2113400 Negative_regulation FOXO1 MLST8 23614736 829982 Negative_regulation FOXO1 MLST8 23783557 2117494 Negative_regulation FOXO1 MLST8 23800068 830078 Negative_regulation FOXO1 MLST8 23800068 830079 Negative_regulation FOXO1 MLST8 23800068 830179 Negative_regulation FOXO1 MLST8 23800068 830210 Negative_regulation FOXO1 MTOR 22476916 1238835 Negative_regulation FOXO1 MTOR 22891897 2113405 Negative_regulation FOXO1 MTOR 23028409 2219962 Negative_regulation FOXO1 MTOR 23614736 829984 Negative_regulation FOXO1 MTOR 23783557 2117497 Negative_regulation FOXO1 MTOR 23800068 830087 Negative_regulation FOXO1 MTOR 23800068 830088 Negative_regulation FOXO1 MTOR 23800068 830181 Negative_regulation FOXO1 MTOR 23800068 830212 Negative_regulation FOXO1 MTOR 24454908 2910307 Negative_regulation FOXO1 MTOR 24757526 1491697 Negative_regulation FOXO1 MYC 24757526 1491705 Negative_regulation FOXO1 MYC 24977668 2194641 Negative_regulation FOXO1 MYC 24977668 2194642 Negative_regulation FOXO1 MYLIP 21170274 2487098 Negative_regulation FOXO1 MYLIP 21386132 29063 Negative_regulation FOXO1 MYLIP 21753893 645334 Negative_regulation FOXO1 MYLIP 21824387 3160479 Negative_regulation FOXO1 MYLIP 23029264 2695768 Negative_regulation FOXO1 MYLIP 23951320 2834196 Negative_regulation FOXO1 MYLIP 23951320 2834199 Negative_regulation FOXO1 MYLIP 24260486 2884610 Negative_regulation FOXO1 MYLIP 24260486 2884611 Negative_regulation FOXO1 MYLIP 24260486 2884625 Negative_regulation FOXO1 MYLIP 24627810 1691102 Negative_regulation FOXO1 MYLIP 25018733 965426 Negative_regulation FOXO1 NAV1 22400069 2608770 Negative_regulation FOXO1 NAV1 22400069 2608775 Negative_regulation FOXO1 NFATC1 21148296 1784449 Negative_regulation FOXO1 NFKB1 17531095 2013457 Negative_regulation FOXO1 NGF 12913110 1295258 Negative_regulation FOXO1 NLK 25329475 3016163 Negative_regulation FOXO1 OPN1LW 24379407 1208820 Negative_regulation FOXO1 OPN1LW 24379407 1208821 Negative_regulation FOXO1 OPN1LW 24379407 1208850 Negative_regulation FOXO1 PAK1 25335797 3071373 Negative_regulation FOXO1 PAX3 23469153 2762474 Negative_regulation FOXO1 PGC 25375380 578989 Negative_regulation FOXO1 PHOSPHO1 22156377 30047 Negative_regulation FOXO1 PHOSPHO2 22156377 30048 Negative_regulation FOXO1 PI3 23805138 907946 Negative_regulation FOXO1 PIK3CA 18000534 2380613 Negative_regulation FOXO1 PIK3CA 18978794 1951906 Negative_regulation FOXO1 PIK3CA 19043547 2306830 Negative_regulation FOXO1 PIK3CA 19043547 2306852 Negative_regulation FOXO1 PIK3CA 20089194 284060 Negative_regulation FOXO1 PIK3CA 20642839 1647237 Negative_regulation FOXO1 PIK3CA 21144036 1647946 Negative_regulation FOXO1 PIK3CA 21980390 2560017 Negative_regulation FOXO1 PIK3CA 22870349 696128 Negative_regulation FOXO1 PIK3CA 23028409 2219963 Negative_regulation FOXO1 PIK3CA 23630664 943102 Negative_regulation FOXO1 PIK3CA 23991359 20513 Negative_regulation FOXO1 PIK3CA 24036443 1112499 Negative_regulation FOXO1 PIK3CA 24357229 171304 Negative_regulation FOXO1 PIK3CA 24765092 912280 Negative_regulation FOXO1 PIK3CA 25157276 1240794 Negative_regulation FOXO1 PIK3CA 25157276 1240796 Negative_regulation FOXO1 PIK3R1 18000534 2380614 Negative_regulation FOXO1 PIK3R1 18978794 1951907 Negative_regulation FOXO1 PIK3R1 19043547 2306831 Negative_regulation FOXO1 PIK3R1 19043547 2306853 Negative_regulation FOXO1 PIK3R1 20089194 284061 Negative_regulation FOXO1 PIK3R1 20642839 1647238 Negative_regulation FOXO1 PIK3R1 21144036 1647947 Negative_regulation FOXO1 PIK3R1 21980390 2560018 Negative_regulation FOXO1 PIK3R1 22870349 696129 Negative_regulation FOXO1 PIK3R1 23028409 2219964 Negative_regulation FOXO1 PIK3R1 23630664 943103 Negative_regulation FOXO1 PIK3R1 23991359 20514 Negative_regulation FOXO1 PIK3R1 24036443 1112500 Negative_regulation FOXO1 PIK3R1 24357229 171305 Negative_regulation FOXO1 PIK3R1 24765092 912281 Negative_regulation FOXO1 PIK3R1 25157276 1240795 Negative_regulation FOXO1 PIK3R1 25157276 1240797 Negative_regulation FOXO1 POLDIP2 24159000 728715 Negative_regulation FOXO1 PPARA 23372643 2745601 Negative_regulation FOXO1 PPARG 22399922 3158678 Negative_regulation FOXO1 PRKACB 22510882 771761 Negative_regulation FOXO1 PRKACG 22510882 771762 Negative_regulation FOXO1 PRKAR1A 22510882 771763 Negative_regulation FOXO1 PRKAR1B 22510882 771764 Negative_regulation FOXO1 PRKAR2A 22510882 771765 Negative_regulation FOXO1 PRKAR2B 22510882 771766 Negative_regulation FOXO1 PRNP 23967259 2835432 Negative_regulation FOXO1 PRR5 23783557 2117496 Negative_regulation FOXO1 PRR5 23800068 830083 Negative_regulation FOXO1 PTEN 20519781 27343 Negative_regulation FOXO1 PTEN 21386132 29064 Negative_regulation FOXO1 PTEN 21980390 2560181 Negative_regulation FOXO1 PTEN 23638435 943401 Negative_regulation FOXO1 PTEN 25418061 1018820 Negative_regulation FOXO1 PTPN1 23737779 1073561 Negative_regulation FOXO1 RELA 17531095 2013458 Negative_regulation FOXO1 RENBP 20300563 1910596 Negative_regulation FOXO1 RHEB 22476916 1238833 Negative_regulation FOXO1 RICTOR 22891897 2113401 Negative_regulation FOXO1 RICTOR 23783557 2117495 Negative_regulation FOXO1 RICTOR 23800068 830081 Negative_regulation FOXO1 RPTOR 23614736 829983 Negative_regulation FOXO1 RPTOR 23800068 830082 Negative_regulation FOXO1 RPTOR 23800068 830180 Negative_regulation FOXO1 RPTOR 23800068 830211 Negative_regulation FOXO1 RUNX2 24479521 474450 Negative_regulation FOXO1 RYK 24960609 2286323 Negative_regulation FOXO1 SCGB1D4 20976250 2319428 Negative_regulation FOXO1 SCGB1D4 23271974 2340592 Negative_regulation FOXO1 SCGB1D4 23906066 700811 Negative_regulation FOXO1 SCGB1D4 23906066 700848 Negative_regulation FOXO1 SGK1 19209957 2266064 Negative_regulation FOXO1 SGK1 21164222 28865 Negative_regulation FOXO1 SGK1 22359667 2598705 Negative_regulation FOXO1 SGK1 23434669 1102223 Negative_regulation FOXO1 SGK1 23786484 32898 Negative_regulation FOXO1 SGK1 23786484 32899 Negative_regulation FOXO1 SH2B1 20868529 1647816 Negative_regulation FOXO1 SIK2 22662228 2647524 Negative_regulation FOXO1 SIRT1 20157548 25881 Negative_regulation FOXO1 SIRT1 23342163 2742618 Negative_regulation FOXO1 SIRT1 23884882 728051 Negative_regulation FOXO1 SIRT1 24040102 2845699 Negative_regulation FOXO1 SLC25A14 21460183 1789198 Negative_regulation FOXO1 SMAD3 25423188 3029944 Negative_regulation FOXO1 SOD1 18487450 705966 Negative_regulation FOXO1 SON 21460183 1789199 Negative_regulation FOXO1 SPDYA 22280365 263362 Negative_regulation FOXO1 SPDYA 22280365 263369 Negative_regulation FOXO1 SPRY1 23554919 2773834 Negative_regulation FOXO1 SPRY4 23554919 2773980 Negative_regulation FOXO1 STAT1 23401241 779866 Negative_regulation FOXO1 STAT3 21765927 2536265 Negative_regulation FOXO1 STK4 24525530 1940626 Negative_regulation FOXO1 TARDBP 25329970 2366543 Negative_regulation FOXO1 TCF7L2 22892353 521433 Negative_regulation FOXO1 TCF7L2 22934027 958523 Negative_regulation FOXO1 TNF 20300563 1910595 Negative_regulation FOXO1 TNFSF11 24781012 1941812 Negative_regulation FOXO1 TNK2 20333297 2444170 Negative_regulation FOXO1 TP53 24757526 1491691 Negative_regulation FOXO1 TSC22D3 23516608 2768716 Negative_regulation FOXO1 TSC22D3 23516608 2768723 Negative_regulation FOXO1 TSC22D3 23516608 2768727 Negative_regulation FOXO1 TST 22280365 263368 Negative_regulation FOXO1 USP7 24756567 3082169 Negative_regulation FOXO1 VAV1 21957439 2557179 Negative_regulation FOXO1 VEGFA 18000534 2380603 Negative_regulation FOXO1 XBP1 23277279 610791 Negative_regulation FOXO1 XBP1 23277279 610861 Negative_regulation FOXO1 XBP1 23277279 610869 Negative_regulation FOXO1 XBP1 23277279 610907 Negative_regulation FOXO1 XBP1 23572207 3158225 Negative_regulation FOXO1 XBP1 23572207 3158242 Negative_regulation FOXO1 ZGLP1 21716694 831716 Negative_regulation FOXO1 ZGLP1 22013015 720924 Negative_regulation FOXO1 ZGLP1 22013015 720936 Negative_regulation FOXO3 EPHB2 20885957 2475702 Negative_regulation FOXO3 EPHB2 21249150 2493171 Negative_regulation FOXO3 FBXO32 22586590 722919 Negative_regulation FOXO3 INPP4B 21487159 2175783 Negative_regulation FOXO3 PGC 21629705 1155181 Negative_regulation FOXO3 SPHK1 21625639 2525205 Negative_regulation FOXO3 TNFSF10 21209944 2492481 Negative_regulation FOXO3 TNFSF10 21209944 2492504 Negative_regulation FOXO3 TNFSF10 21209944 2492514 Negative_regulation FOXO3 TNFSF10 21209944 2492516 Negative_regulation FOXP3 EPHB2 25147435 1761198 Negative_regulation FOXP3 FOXO1 21603204 632622 Negative_regulation FOXP3 HBEGF 25264896 3010769 Negative_regulation FOXP3 ITGB2 25108241 1621231 Negative_regulation FOXP3 PLAU 23169000 1904603 Negative_regulation FOXP3 RORC 25621490 3038864 Negative_regulation FOXP3 TLR7 23593527 2371843 Negative_regulation FOXP3 TNF 23133752 97696 Negative_regulation FOXP3 TNF 23593527 2371841 Negative_regulation FOXP3 TNF 25387791 3146867 Negative_regulation FOXQ1 CDH1 25356753 2206492 Negative_regulation FRS2 EPHB2 22235335 2585904 Negative_regulation FSHB FOXO1 25423188 3029956 Negative_regulation FSHB FOXO1 25423188 3030040 Negative_regulation FSHB FOXO1 25423188 3030079 Negative_regulation FSHB FOXO1 25423188 3030085 Negative_regulation FSTL1 TNF 19966777 1960916 Negative_regulation FURIN MMP28 23936445 2830542 Negative_regulation FURIN MMP28 23936445 2830763 Negative_regulation FURIN MMP7 23936445 2830557 Negative_regulation FURIN MMP7 23936445 2830779 Negative_regulation FURIN PCSK9 23936445 2830764 Negative_regulation FUT1 HBEGF 22330337 1717965 Negative_regulation FUT1 HBEGF 22330337 1717970 Negative_regulation FUT1 ID1 22006249 616708 Negative_regulation FUT1 TLR7 20706677 979143 Negative_regulation FUT1 TNF 21768269 1564318 Negative_regulation FUT1 TNF 21768269 1564319 Negative_regulation FUT4 HNF1A 21203500 2320842 Negative_regulation FUT4 HNF4A 21203500 2320843 Negative_regulation FUT4 MYB 22709531 482569 Negative_regulation FUT7 FUT4 14597733 1529405 Negative_regulation FUT7 FUT4 14597733 1529421 Negative_regulation FXN PGC 23418481 2753994 Negative_regulation FZD4 CD82 23076981 1141283 Negative_regulation FZD4 DKK1 21552419 1057148 Negative_regulation FZD4 DKK4 18702828 143258 Negative_regulation FZD4 KREMEN1 21668411 149342 Negative_regulation FZD4 LRP1 22645520 873626 Negative_regulation FZD4 LRP10 22645520 873623 Negative_regulation FZD4 LRP11 22645520 873624 Negative_regulation FZD4 LRP12 22645520 873625 Negative_regulation FZD4 LRP2 22645520 873627 Negative_regulation FZD4 LRP3 22645520 873628 Negative_regulation FZD4 LRP4 22645520 873629 Negative_regulation FZD4 LRP5 22645520 873630 Negative_regulation FZD4 LRP6 22645520 873631 Negative_regulation FZD4 LRP8 22645520 873632 Negative_regulation FZD4 SLC9A3R1 20802536 2135772 Negative_regulation FZD4 WNT1 21668411 148896 Negative_regulation FZD4 WNT11 21668411 148897 Negative_regulation FZD4 WNT16 21668411 148902 Negative_regulation FZD4 WNT2 21668411 148898 Negative_regulation FZD4 WNT3 21668411 148899 Negative_regulation FZD4 WNT4 21668411 148900 Negative_regulation FZD4 WNT4 24178749 783309 Negative_regulation FZD4 WNT6 21668411 148901 Negative_regulation FZD5 KLF9 18783612 3096694 Negative_regulation G0S2 TNF 23499576 3204080 Negative_regulation G6PC EPHB2 22848439 2669013 Negative_regulation G6PC FOXO1 22860063 2671430 Negative_regulation G6PC FOXO1 23442260 1036514 Negative_regulation G6PC PGC 20864515 716602 Negative_regulation G6PC PGC 23442260 1036515 Negative_regulation GABPA EPHB2 24520207 650214 Negative_regulation GABPA MAP2K6 23187004 219808 Negative_regulation GADD45A EPHB2 25068118 3167136 Negative_regulation GADD45A FOXO1 24145170 1411727 Negative_regulation GAL GNE 20383336 2445905 Negative_regulation GAL TLR7 23202469 3221684 Negative_regulation GAL TLR7 23202469 3221702 Negative_regulation GAPDH EPHB2 22964641 2148628 Negative_regulation GAPDH EPHB2 22964641 2148653 Negative_regulation GAPDH EPHB2 22964641 2148665 Negative_regulation GAPDH EPHB2 22964641 2148674 Negative_regulation GAST IL1B 21445336 2509447 Negative_regulation GAST IL1B 21445336 2509449 Negative_regulation GATA1 FAS 11208865 1518751 Negative_regulation GATA1 ZFP57 21539723 3168912 Negative_regulation GATA2 CDKN1C 20877475 2272531 Negative_regulation GATA3 CTGF 12810687 1527670 Negative_regulation GATA3 EPHB2 16172258 1537771 Negative_regulation GATA3 IL1RL1 25115682 686558 Negative_regulation GATA3 RORC 25621490 3038863 Negative_regulation GATA3 STAT4 19808254 1556470 Negative_regulation GATA3 TNF 21611195 2523822 Negative_regulation GATA4 EPHB2 21702924 508538 Negative_regulation GATA4 MAP2K6 21702924 508544 Negative_regulation GBP3 MAP2K6 21306619 332324 Negative_regulation GC TNF 18854046 1727795 Negative_regulation GCG FOXO1 21283589 2496905 Negative_regulation GCG GLP1R 21731863 1044098 Negative_regulation GCG GLP1R 21876656 648750 Negative_regulation GCG GLP1R 23649520 727266 Negative_regulation GCG GPR115 22811709 1073287 Negative_regulation GCG GPR132 22811709 1073276 Negative_regulation GCG GPR87 22811709 1073357 Negative_regulation GCGR GLP1R 22701182 1151111 Negative_regulation GCGR GLP1R 23818527 727639 Negative_regulation GDF10 LBP 23971008 864233 Negative_regulation GDF15 G0S2 24039668 2844510 Negative_regulation GDF15 MMP28 18778487 384829 Negative_regulation GDF9 TNF 23565150 2777019 Negative_regulation GDI1 RAB31 21931684 2554053 Negative_regulation GDI2 RAB31 21931684 2554080 Negative_regulation GEMIN2 SMN2 21339974 1090441 Negative_regulation GEMIN2 SMN2 24210254 2008271 Negative_regulation GEMIN4 SMN2 21339974 1090469 Negative_regulation GEMIN4 SMN2 24210254 2008299 Negative_regulation GEMIN5 SMN2 21339974 1090476 Negative_regulation GEMIN5 SMN2 24210254 2008306 Negative_regulation GEMIN6 SMN2 21339974 1090483 Negative_regulation GEMIN6 SMN2 24210254 2008313 Negative_regulation GEMIN7 SMN2 21339974 1090490 Negative_regulation GEMIN7 SMN2 24210254 2008320 Negative_regulation GFAP JAG1 16820778 1901669 Negative_regulation GFAP NES 22650359 1506413 Negative_regulation GFAP NES 22650359 1506416 Negative_regulation GFAP NES 25206670 2005529 Negative_regulation GFAP TNF 19247457 1908999 Negative_regulation GGA1 MAOA 23170116 842657 Negative_regulation GGA2 MAOA 23170116 842655 Negative_regulation GGA3 MAOA 23170116 842656 Negative_regulation GH1 FOXA1 23284914 2731279 Negative_regulation GHR FOXO1 23614736 829995 Negative_regulation GHR FOXO1 23614736 829996 Negative_regulation GHR FOXO1 23614736 830023 Negative_regulation GHR TNF 18793716 613133 Negative_regulation GIP GLP1R 20215429 713028 Negative_regulation GIT1 FAS 21695141 2529528 Negative_regulation GJA1 EPHB2 21575204 286622 Negative_regulation GJA1 F2R 20936153 696692 Negative_regulation GJA1 F2R 22190975 633777 Negative_regulation GJA1 F2R 25309448 966251 Negative_regulation GJA1 MMP28 24002703 1880041 Negative_regulation GJA1 MMP7 24002703 1880069 Negative_regulation GJA1 S100B 18958191 860268 Negative_regulation GJA1 S100B 19225596 935823 Negative_regulation GJA1 TLR7 24236122 2878623 Negative_regulation GJA1 TNF 22590660 2371273 Negative_regulation GJA1 TNF 23755184 2801846 Negative_regulation GJA3 TNF 15159208 792145 Negative_regulation GJB2 GJB6 25386120 872032 Negative_regulation GJB2 KDM5B 23579952 1105436 Negative_regulation GJB2 KDM5B 23579952 1105437 Negative_regulation GJB2 KDM5B 23579952 1105442 Negative_regulation GJB2 KDM5B 23579952 1105443 Negative_regulation GJB2 KDM5B 23579952 1105444 Negative_regulation GJB2 MBD2 25018732 965412 Negative_regulation GJB2 NOS1 25013956 2988499 Negative_regulation GJB2 NOS2 25013956 2988500 Negative_regulation GJB2 NOS3 25013956 2988501 Negative_regulation GLI1 EPHB2 23097684 2181601 Negative_regulation GLI1 MAP2K6 23097684 2181607 Negative_regulation GLP1R DPP4 22761607 833204 Negative_regulation GLP1R DPP4 23818527 727636 Negative_regulation GLP1R DPP4 24499291 1072320 Negative_regulation GLP1R GCGR 22701182 1151112 Negative_regulation GLP1R GIPR 22412906 2609688 Negative_regulation GLP1R INS 23291632 1736424 Negative_regulation GLP1R LEPR 23284795 2731003 Negative_regulation GLP1R PDX1 18544709 706239 Negative_regulation GLP1R PRKAA1 24843641 1494212 Negative_regulation GLP1R PRKAA2 24843641 1494213 Negative_regulation GLP1R PRKAB1 24843641 1494214 Negative_regulation GLP1R PRKAB2 24843641 1494215 Negative_regulation GLP1R PRKAG1 24843641 1494216 Negative_regulation GLP1R PRKAG2 24843641 1494217 Negative_regulation GLP1R PTGER3 23349487 725741 Negative_regulation GLP1R SRGN 23825925 731495 Negative_regulation GLP1R ZGLP1 21430088 718899 Negative_regulation GLP1R ZGLP1 23825925 731494 Negative_regulation GLP1R ZGLP1 24302978 2887153 Negative_regulation GLUL MSX1 16046826 1212284 Negative_regulation GNE CHKA 24996846 274235 Negative_regulation GNE NEU1 19841673 2428905 Negative_regulation GNG10 FAS 22676303 1724577 Negative_regulation GNG10 FAS 22676303 1724641 Negative_regulation GNG10 FAS 22676303 1724682 Negative_regulation GNG11 FAS 22676303 1724578 Negative_regulation GNG11 FAS 22676303 1724642 Negative_regulation GNG11 FAS 22676303 1724683 Negative_regulation GNG12 FAS 22676303 1724573 Negative_regulation GNG12 FAS 22676303 1724639 Negative_regulation GNG12 FAS 22676303 1724680 Negative_regulation GNG13 FAS 22676303 1724571 Negative_regulation GNG13 FAS 22676303 1724638 Negative_regulation GNG13 FAS 22676303 1724679 Negative_regulation GNG2 FAS 22676303 1724579 Negative_regulation GNG2 FAS 22676303 1724643 Negative_regulation GNG2 FAS 22676303 1724684 Negative_regulation GNG3 FAS 22676303 1724580 Negative_regulation GNG3 FAS 22676303 1724644 Negative_regulation GNG3 FAS 22676303 1724685 Negative_regulation GNG4 FAS 22676303 1724581 Negative_regulation GNG4 FAS 22676303 1724645 Negative_regulation GNG4 FAS 22676303 1724686 Negative_regulation GNG5 FAS 22676303 1724582 Negative_regulation GNG5 FAS 22676303 1724646 Negative_regulation GNG5 FAS 22676303 1724687 Negative_regulation GNG7 FAS 22676303 1724583 Negative_regulation GNG7 FAS 22676303 1724647 Negative_regulation GNG7 FAS 22676303 1724688 Negative_regulation GNG8 FAS 22676303 1724574 Negative_regulation GNG8 FAS 22676303 1724640 Negative_regulation GNG8 FAS 22676303 1724681 Negative_regulation GNRH1 FOXO1 25423188 3030041 Negative_regulation GNRH1 TNF 25349479 731671 Negative_regulation GNRH2 TNF 25349479 731673 Negative_regulation GOLGA2 EPHB2 23325787 1810980 Negative_regulation GORASP1 EPHB2 18762583 1357042 Negative_regulation GORASP1 EPHB2 18762583 1357070 Negative_regulation GORASP1 MAP2K6 18762583 1357076 Negative_regulation GP2 CLU 15987443 458886 Negative_regulation GP2 CLU 18433489 361485 Negative_regulation GP2 CLU 18433489 361488 Negative_regulation GP2 CLU 18433489 361489 Negative_regulation GP2 CLU 19903339 362372 Negative_regulation GP6 PECAM1 23185356 2719997 Negative_regulation GPAM TNF 19925655 327030 Negative_regulation GPI PTGIS 21701627 745533 Negative_regulation GPI RGS2 24743392 2955258 Negative_regulation GPI SLC9A2 20011065 1213386 Negative_regulation GPI TNF 24739042 3114537 Negative_regulation GPNMB ABL1 23874106 2121506 Negative_regulation GPNMB BCR 23874106 2121502 Negative_regulation GPNMB CD79A 23874106 2121504 Negative_regulation GPNMB CD79B 23874106 2121505 Negative_regulation GPNMB DCP2 20352036 2220525 Negative_regulation GPNMB EXOSC10 20352036 2220528 Negative_regulation GPNMB EXOSC2 20352036 2220521 Negative_regulation GPNMB EXOSC4 20352036 2220523 Negative_regulation GPNMB FLCN 21209915 2492396 Negative_regulation GPNMB FLCN 21209915 2492422 Negative_regulation GPNMB FLCN 21209915 2492450 Negative_regulation GPNMB FNIP1 21209915 2492420 Negative_regulation GPNMB FNIP1 21209915 2492424 Negative_regulation GPNMB FNIP1 21209915 2492451 Negative_regulation GPNMB FNIP2 21209915 2492423 Negative_regulation GPNMB PARN 20352036 2220527 Negative_regulation GPNMB SRC 23874106 2121503 Negative_regulation GPNMB UPF1 20352036 2220529 Negative_regulation GPNMB UPF2 20352036 2220522 Negative_regulation GPNMB UPF3B 20352036 2220524 Negative_regulation GPNMB XRN1 20352036 2220526 Negative_regulation GPNMB XRN2 20352036 2220520 Negative_regulation GPR115 ARRB1 21843342 411901 Negative_regulation GPR115 DRD2 19320994 385472 Negative_regulation GPR115 GCG 22811709 1073234 Negative_regulation GPR115 PTCH1 19575820 1851064 Negative_regulation GPR115 PTCH1 24973920 1964160 Negative_regulation GPR115 PTX3 12615905 1526178 Negative_regulation GPR115 PTX3 21825019 1564665 Negative_regulation GPR115 PTX4 12615905 1526177 Negative_regulation GPR115 PTX4 21825019 1564664 Negative_regulation GPR115 RIC8A 19432969 362010 Negative_regulation GPR132 ARRB1 21843342 411890 Negative_regulation GPR132 ATP5O 6146631 1429810 Negative_regulation GPR132 CD8A 23094142 1669606 Negative_regulation GPR132 DRD2 19320994 385461 Negative_regulation GPR132 GCG 22811709 1073223 Negative_regulation GPR132 PTCH1 19575820 1851053 Negative_regulation GPR132 PTCH1 24973920 1964149 Negative_regulation GPR132 PTX3 12615905 1526156 Negative_regulation GPR132 PTX3 21825019 1564643 Negative_regulation GPR132 PTX4 12615905 1526155 Negative_regulation GPR132 PTX4 21825019 1564642 Negative_regulation GPR132 RIC8A 19432969 361999 Negative_regulation GPR87 ARRB1 21843342 411970 Negative_regulation GPR87 DRD2 19320994 385541 Negative_regulation GPR87 GCG 22811709 1073398 Negative_regulation GPR87 PTCH1 19575820 1851133 Negative_regulation GPR87 PTCH1 24973920 1964230 Negative_regulation GPR87 PTX3 12615905 1526316 Negative_regulation GPR87 PTX3 21825019 1564803 Negative_regulation GPR87 PTX4 12615905 1526315 Negative_regulation GPR87 PTX4 21825019 1564802 Negative_regulation GPR87 RIC8A 19432969 362079 Negative_regulation GPX1 ALOX5 25642165 873029 Negative_regulation GPX1 PGC 22742579 292148 Negative_regulation GPX1 TNF 24381587 23167 Negative_regulation GPX2 ALOX5 25642165 873030 Negative_regulation GPX2 TNF 24381587 23169 Negative_regulation GPX3 ALOX5 25642165 873031 Negative_regulation GPX3 TNF 24381587 23171 Negative_regulation GPX4 ALOX5 25642165 873032 Negative_regulation GPX4 TNF 24381587 23173 Negative_regulation GPX5 ALOX5 25642165 873033 Negative_regulation GPX5 TNF 24381587 23175 Negative_regulation GPX6 ALOX5 25642165 873034 Negative_regulation GPX6 TNF 24381587 23177 Negative_regulation GPX7 ALOX5 25642165 873035 Negative_regulation GPX7 TNF 24381587 23179 Negative_regulation GPX8 ALOX5 25642165 873028 Negative_regulation GPX8 TNF 24381587 23165 Negative_regulation GRAP2 EPHB2 20093365 1169050 Negative_regulation GRAP2 EPHB2 21048967 2480295 Negative_regulation GRAP2 EPHB2 22605923 1914328 Negative_regulation GRAP2 EPHB2 23418602 2754831 Negative_regulation GRAP2 EPHB2 24348728 824740 Negative_regulation GRAP2 EPHB2 25165721 198170 Negative_regulation GRAP2 EPHB2 25312253 3146144 Negative_regulation GRAP2 MAP2K6 23638878 1868137 Negative_regulation GRAP2 MAP2K6 24232636 2235867 Negative_regulation GRAP2 MAP2K6 25165721 198176 Negative_regulation GRAP2 STK39 17988378 392884 Negative_regulation GRAP2 TLR7 22720096 2654448 Negative_regulation GRAP2 TNF 22675384 814592 Negative_regulation GREB1 FOXA1 21878914 1904085 Negative_regulation GREB1 MAP2K6 24727858 2951737 Negative_regulation GRHL2 WNT7A 23284647 2730368 Negative_regulation GRHL2 WNT7A 23284647 2730381 Negative_regulation GRIA1 NES 23749147 1968425 Negative_regulation GRIA4 TNF 24344780 1667476 Negative_regulation GRIK2 RAB11A 23556457 3187406 Negative_regulation GRIN1 TCN1 24522697 3139787 Negative_regulation GRIN2A TCN1 24522697 3139784 Negative_regulation GRP EPHB2 23211542 2181811 Negative_regulation GYS1 EPHB2 20700369 1911811 Negative_regulation GYS1 FOXO1 21335550 1190790 Negative_regulation GYS1 MAP2K6 24936463 3167000 Negative_regulation GYS1 S100B 23533154 178289 Negative_regulation GYS2 EPHB2 20700369 1911812 Negative_regulation GYS2 FOXO1 21335550 1190791 Negative_regulation GYS2 MAP2K6 24936463 3167007 Negative_regulation GYS2 S100B 23533154 178290 Negative_regulation GZMB BPI 12186841 1524550 Negative_regulation H3F3A EZH2 24894482 6110 Negative_regulation HAMP TF 20467559 21506 Negative_regulation HAMP TNF 22998440 1231248 Negative_regulation HAMP TNF 22998440 1231260 Negative_regulation HAMP TNF 24286116 130131 Negative_regulation HAMP TNF 24286116 130132 Negative_regulation HAMP TNF 24286116 130146 Negative_regulation HAMP TNF 24286116 130160 Negative_regulation HAS1 HAS3 PMC2833623 134248 Negative_regulation HAS2 HAS3 22203782 1223618 Negative_regulation HAVCR1 EPHB2 20566714 1558510 Negative_regulation HAVCR2 TLR7 23967307 2835747 Negative_regulation HAVCR2 TLR7 23967307 2835979 Negative_regulation HAVCR2 TLR7 23967307 2835980 Negative_regulation HBD SPHK1 20634980 2455668 Negative_regulation HBEGF ADAM15 14993236 1306903 Negative_regulation HBEGF ADAM17 21386996 2506122 Negative_regulation HBEGF ADIPOQ 25110685 196158 Negative_regulation HBEGF AKT1 22792252 2661632 Negative_regulation HBEGF AKT2 22792252 2661633 Negative_regulation HBEGF AKT3 22792252 2661634 Negative_regulation HBEGF EDN1 20452970 1187753 Negative_regulation HBEGF EGF 22330337 1717969 Negative_regulation HBEGF EGFR 22157721 1717935 Negative_regulation HBEGF EGFR 25033458 2990297 Negative_regulation HBEGF F2RL1 24009895 1605694 Negative_regulation HBEGF FGF2 8349739 1447590 Negative_regulation HBEGF MAP2K1 22157721 1717813 Negative_regulation HBEGF MAP2K2 22157721 1717814 Negative_regulation HBEGF MYLIP 22362752 2072657 Negative_regulation HBEGF MYLIP 23437250 2756303 Negative_regulation HBEGF MYLIP 24136232 568217 Negative_regulation HBEGF MYLIP 24481448 571776 Negative_regulation HBEGF NOS1 23760291 1709465 Negative_regulation HBEGF NOS1 23760291 1709466 Negative_regulation HBEGF NOS1 23760291 1709470 Negative_regulation HBEGF NOS1 23760291 1709471 Negative_regulation HBEGF NPY6R 22747893 1664274 Negative_regulation HBEGF NRG1 22792252 2661568 Negative_regulation HBEGF PIK3CA 22157721 1717936 Negative_regulation HBEGF PIK3R1 22157721 1717937 Negative_regulation HBEGF PTN 16908672 1332020 Negative_regulation HBEGF PTN 16908672 1332050 Negative_regulation HBEGF RUNX2 24136232 568220 Negative_regulation HBEGF RUNX2 24136232 568221 Negative_regulation HBEGF S100A6 23029355 2696776 Negative_regulation HBEGF SLC22A3 20584780 1023276 Negative_regulation HBEGF SRC 22446737 1928269 Negative_regulation HCCS CCND1 19402906 1503675 Negative_regulation HDAC1 ALOX5 25402609 2160656 Negative_regulation HDAC1 CCND1 17407548 1846386 Negative_regulation HDAC1 CCND1 23836985 2121414 Negative_regulation HDAC1 CLU 23362253 1206176 Negative_regulation HDAC1 CST6 19503093 2125518 Negative_regulation HDAC1 CST6 19503093 2125525 Negative_regulation HDAC1 MMP28 15899037 103487 Negative_regulation HDAC1 MMP7 15899037 103503 Negative_regulation HDAC1 TLR7 22312110 1567083 Negative_regulation HDAC1 TNF 22022321 923681 Negative_regulation HDAC1 TNF 25136952 2999249 Negative_regulation HDAC1 TNFSF10 16930472 249684 Negative_regulation HDAC1 TNFSF10 20671809 2174377 Negative_regulation HDAC1 TNFSF10 21931726 2554263 Negative_regulation HDAC10 CST6 19503093 2125504 Negative_regulation HDAC10 TNF 22022321 923679 Negative_regulation HDAC10 TNFSF10 20671809 2174375 Negative_regulation HDAC11 CST6 19503093 2125505 Negative_regulation HDAC11 TNF 22022321 923680 Negative_regulation HDAC11 TNFSF10 20671809 2174376 Negative_regulation HDAC2 ALOX5 25402609 2160658 Negative_regulation HDAC2 CCND1 17407548 1846387 Negative_regulation HDAC2 CCND1 23836985 2121426 Negative_regulation HDAC2 CLU 23362253 1206177 Negative_regulation HDAC2 CST6 19503093 2125519 Negative_regulation HDAC2 CST6 19503093 2125526 Negative_regulation HDAC2 MMP28 15899037 103512 Negative_regulation HDAC2 MMP7 15899037 103528 Negative_regulation HDAC2 TLR7 22312110 1567093 Negative_regulation HDAC2 TNF 22022321 923682 Negative_regulation HDAC2 TNF 25136952 2999250 Negative_regulation HDAC2 TNFSF10 16930472 249685 Negative_regulation HDAC2 TNFSF10 20671809 2174378 Negative_regulation HDAC2 TNFSF10 21931726 2554264 Negative_regulation HDAC3 CST6 19503093 2125520 Negative_regulation HDAC3 TNF 22022321 923683 Negative_regulation HDAC3 TNFSF10 20671809 2174379 Negative_regulation HDAC4 CST6 19503093 2125499 Negative_regulation HDAC4 TNF 22022321 923674 Negative_regulation HDAC4 TNFSF10 20671809 2174370 Negative_regulation HDAC5 CST6 19503093 2125503 Negative_regulation HDAC5 TNF 22022321 923678 Negative_regulation HDAC5 TNFSF10 20671809 2174374 Negative_regulation HDAC6 CST6 19503093 2125500 Negative_regulation HDAC6 EPHB2 24023871 2843837 Negative_regulation HDAC6 EPHB2 24023871 2843891 Negative_regulation HDAC6 TNF 22022321 923675 Negative_regulation HDAC6 TNFSF10 20671809 2174371 Negative_regulation HDAC7 CST6 19503093 2125502 Negative_regulation HDAC7 TNF 22022321 923677 Negative_regulation HDAC7 TNFSF10 20671809 2174373 Negative_regulation HDAC8 AGR2 25011684 1508191 Negative_regulation HDAC8 CST6 19503093 2125498 Negative_regulation HDAC8 TNF 22022321 923673 Negative_regulation HDAC8 TNFSF10 20671809 2174369 Negative_regulation HDAC9 CST6 19503093 2125501 Negative_regulation HDAC9 TNF 22022321 923676 Negative_regulation HDAC9 TNFSF10 20671809 2174372 Negative_regulation HEPACAM2 TFPI2 22761571 3057406 Negative_regulation HES1 EPHB2 20652960 3170784 Negative_regulation HES1 FHL1 24952875 274080 Negative_regulation HES1 FOXO1 20567496 1056172 Negative_regulation HES1 TNF 23531541 1103924 Negative_regulation HES2 NOTCH1 19050759 2401649 Negative_regulation HES2 NOTCH1 24563863 187182 Negative_regulation HES2 NOTCH1 24832654 176959 Negative_regulation HES2 NOTCH2 19050759 2401650 Negative_regulation HES2 NOTCH2 24563863 187183 Negative_regulation HES2 NOTCH2 24832654 176960 Negative_regulation HES2 NOTCH3 19050759 2401651 Negative_regulation HES2 NOTCH3 24563863 187184 Negative_regulation HES2 NOTCH3 24832654 176961 Negative_regulation HES2 NOTCH4 19050759 2401652 Negative_regulation HES2 NOTCH4 24563863 187185 Negative_regulation HES2 NOTCH4 24832654 176962 Negative_regulation HES2 RBPJ 22971775 604887 Negative_regulation HES5 FHL1 24952875 274079 Negative_regulation HES5 NRARP 21795391 1792889 Negative_regulation HEXIM1 CCND1 23575664 161542 Negative_regulation HEXIM1 RNASE1 17341462 2026620 Negative_regulation HEY2 EPHB2 18545664 2390495 Negative_regulation HGF F2R 24876677 1758975 Negative_regulation HGF FAS PMC2243071 1475583 Negative_regulation HGF IFI27 23915242 1232470 Negative_regulation HGF NGFR 24632812 2934256 Negative_regulation HGF PLAU 17134505 312981 Negative_regulation HGF PLAU 8980383 445867 Negative_regulation HGF TNF 25119536 505046 Negative_regulation HHIP PDZK1 21653824 1791372 Negative_regulation HIF1A EGLN3 25161887 1888482 Negative_regulation HIST2H3C ITGAL 17325197 1544508 Negative_regulation HK2 CCND1 20721988 774922 Negative_regulation HLA-A TLR7 20379390 1214393 Negative_regulation HLA-DRA TLR7 23305363 693873 Negative_regulation HLA-DRA TLR7 23691339 1151668 Negative_regulation HLA-DRA TNF 22566973 900660 Negative_regulation HLA-DRB1 CCND1 21179458 2488030 Negative_regulation HLA-DRB1 CCND1 21179458 2488062 Negative_regulation HLA-DRB1 CCND1 21179458 2488063 Negative_regulation HLA-DRB1 CCND1 21179458 2488085 Negative_regulation HLA-DRB1 CCND1 21209944 2492524 Negative_regulation HLA-DRB1 EPHB2 21738740 2533583 Negative_regulation HLA-DRB1 EPHB2 22662193 2647200 Negative_regulation HLA-DRB1 MAP2K6 21738740 2533589 Negative_regulation HLA-DRB1 TLR7 23305363 693883 Negative_regulation HLA-DRB1 TLR7 23691339 1151678 Negative_regulation HLA-DRB1 TNF 22566973 900661 Negative_regulation HLA-DRB1 TNFSF10 22672528 482490 Negative_regulation HLA-DRB1 TNFSF10 23432760 267891 Negative_regulation HLF TNF 18854046 1727797 Negative_regulation HMGA2 EPHB2 23173060 2719471 Negative_regulation HMGB1 EPHB2 25019241 1943130 Negative_regulation HMGB1 F2R 24152910 220927 Negative_regulation HMGB1 TNF 23064724 16107 Negative_regulation HMGN3 FOXO1 22399922 3158673 Negative_regulation HMOX1 EPHB2 23826208 2811473 Negative_regulation HMOX1 F2R 22541814 125607 Negative_regulation HMOX1 F2R 22541814 125633 Negative_regulation HMOX1 FOXO1 24255720 2882081 Negative_regulation HMOX1 FOXO1 24255720 2882082 Negative_regulation HMOX1 TNF 18234118 110133 Negative_regulation HMOX1 TNF 18234118 110141 Negative_regulation HMOX1 TNF 19122672 6831 Negative_regulation HMOX1 TNF 22518295 1080016 Negative_regulation HMOX1 TNF 23285041 2732018 Negative_regulation HMOX1 TNF 23525626 1490466 Negative_regulation HNF4A CCND1 22751438 541604 Negative_regulation HNF4A CCND1 22751438 541605 Negative_regulation HNF4A CCND1 22751438 541609 Negative_regulation HNF4A CCND1 22751438 541610 Negative_regulation HNF4A CCND1 22751438 541611 Negative_regulation HNF4A CCND1 22895168 541738 Negative_regulation HNF4A FOXO1 22399922 3158679 Negative_regulation HNRNPF ABCG2 25111504 2996281 Negative_regulation HNRNPF CD14 21687418 922231 Negative_regulation HNRNPF CD14 23076328 3217280 Negative_regulation HNRNPF EPHB2 20967853 135153 Negative_regulation HNRNPF FAS 10523613 1512618 Negative_regulation HNRNPF HBEGF 22065991 2568213 Negative_regulation HNRNPF MAP2K6 18282094 3040925 Negative_regulation HNRNPF TLR7 18086320 109613 Negative_regulation HNRNPF TNF 21698207 2530802 Negative_regulation HNRNPF TNF 22279513 2219174 Negative_regulation HNRNPF TNF 25071777 913380 Negative_regulation HNRNPF TNF 25123797 368538 Negative_regulation HNRNPF TNF 9362532 1602033 Negative_regulation HNRNPH1 ABCG2 25111504 2996282 Negative_regulation HNRNPH1 CD14 21687418 922232 Negative_regulation HNRNPH1 CD14 23076328 3217284 Negative_regulation HNRNPH1 EPHB2 20967853 135154 Negative_regulation HNRNPH1 FAS 10523613 1512620 Negative_regulation HNRNPH1 HBEGF 22065991 2568214 Negative_regulation HNRNPH1 MAP2K6 18282094 3040932 Negative_regulation HNRNPH1 TLR7 18086320 109623 Negative_regulation HNRNPH1 TNF 21698207 2530803 Negative_regulation HNRNPH1 TNF 22279513 2219175 Negative_regulation HNRNPH1 TNF 25071777 913381 Negative_regulation HNRNPH1 TNF 25123797 368540 Negative_regulation HNRNPH1 TNF 9362532 1602034 Negative_regulation HOXA5 PLAU 23864708 1817016 Negative_regulation HOXB4 MAP2K6 11085749 1518024 Negative_regulation HP TNF 9792335 1763847 Negative_regulation HPX MMP28 16542425 249174 Negative_regulation HPX MMP7 16542425 249189 Negative_regulation HRAS CCND1 18834508 583301 Negative_regulation HRAS EPHB2 19492026 3397 Negative_regulation HRAS EPHB2 19953086 1903257 Negative_regulation HRAS EPHB2 22701199 2234546 Negative_regulation HRAS EPHB2 22745639 1068552 Negative_regulation HRAS EPHB2 25003010 3092912 Negative_regulation HRAS EPHB2 25275294 2202383 Negative_regulation HRAS IFI27 14680481 458013 Negative_regulation HRAS LGALS7B 23530091 2182791 Negative_regulation HRAS LGALS7B 23530091 2182792 Negative_regulation HRAS LGALS7B 23530091 2182793 Negative_regulation HRAS LGALS7B 23530091 2182794 Negative_regulation HRAS LGALS7B 23530091 2182829 Negative_regulation HRAS LGALS7B 23530091 2182861 Negative_regulation HRAS LGALS7B 23530091 2182862 Negative_regulation HRAS LGALS7B 23530091 2182893 Negative_regulation HRAS LGALS7B 23530091 2182903 Negative_regulation HRAS LGALS7B 23530091 2182915 Negative_regulation HRAS MAP2K6 21151481 2485013 Negative_regulation HRAS MAP2K6 24392017 2905186 Negative_regulation HRAS MAP2K6 24970815 2194248 Negative_regulation HRG MAP2K6 23308187 2738547 Negative_regulation HRK TNF 22514694 2619771 Negative_regulation HSD11B1 MAP2K6 24086653 2855427 Negative_regulation HSD11B2 INS 25133511 2998614 Negative_regulation HSD11B2 INS 25133511 2998618 Negative_regulation HSP90AA1 CAPN8 23425388 275392 Negative_regulation HSP90AA1 CAPN8 23425388 275648 Negative_regulation HSP90AA1 CAPN8 23425388 275898 Negative_regulation HSP90AA1 CAPN8 23425388 275912 Negative_regulation HSP90AA1 CAPN8 23565252 2777464 Negative_regulation HSP90AA1 COL17A1 23936217 2829663 Negative_regulation HSP90AA1 EPHB2 23781121 1753380 Negative_regulation HSP90AA1 STAT4 21738677 2533231 Negative_regulation HSP90AA1 TNF 21485744 734857 Negative_regulation HSP90AA1 ZFP57 25032857 577262 Negative_regulation HSP90AA1 ZFP57 25032857 577263 Negative_regulation HSP90AA1 ZFP57 25032857 577349 Negative_regulation HSP90AB1 CAPN8 18200806 3208520 Negative_regulation HSPB1 FAS 18493784 3091125 Negative_regulation HSPB1 SPHK1 24025642 1709535 Negative_regulation HSPD1 TNF 25552899 744062 Negative_regulation HSPG2 FAS 19487421 1555090 Negative_regulation HSPG2 MAP2K6 20924352 1903822 Negative_regulation HTR1A HES2 21619616 1835873 Negative_regulation HTR3A RIC3 20522555 1188061 Negative_regulation HTR3A RIC3 20522555 1188072 Negative_regulation IBD2 CD14 23730203 679418 Negative_regulation IBD2 CHI3L1 19259344 3231591 Negative_regulation IBD2 FAS 25045210 1760140 Negative_regulation IBD2 IL1B 23915129 359237 Negative_regulation IBD2 NT5E 23118501 1225288 Negative_regulation IBD2 TNF 10562322 1513162 Negative_regulation IBD2 TNF 12625840 312759 Negative_regulation IBD2 TNF 15694007 391930 Negative_regulation IBD2 TNF 16259632 1624808 Negative_regulation IBD2 TNF 21853060 2542949 Negative_regulation IBD2 TNF 24339869 2891296 Negative_regulation IBD3 CD14 23730203 679414 Negative_regulation IBD3 CHI3L1 19259344 3231587 Negative_regulation IBD3 FAS 25045210 1760132 Negative_regulation IBD3 IL1B 23915129 359229 Negative_regulation IBD3 NT5E 23118501 1225284 Negative_regulation IBD3 TNF 10562322 1513158 Negative_regulation IBD3 TNF 12625840 312755 Negative_regulation IBD3 TNF 15694007 391926 Negative_regulation IBD3 TNF 16259632 1624804 Negative_regulation IBD3 TNF 21853060 2542945 Negative_regulation IBD3 TNF 24339869 2891292 Negative_regulation IBD4 CD14 23730203 679419 Negative_regulation IBD4 CHI3L1 19259344 3231592 Negative_regulation IBD4 FAS 25045210 1760142 Negative_regulation IBD4 IL1B 23915129 359239 Negative_regulation IBD4 NT5E 23118501 1225289 Negative_regulation IBD4 TNF 10562322 1513163 Negative_regulation IBD4 TNF 12625840 312760 Negative_regulation IBD4 TNF 15694007 391931 Negative_regulation IBD4 TNF 16259632 1624809 Negative_regulation IBD4 TNF 21853060 2542950 Negative_regulation IBD4 TNF 24339869 2891297 Negative_regulation IBD5 CD14 23730203 679420 Negative_regulation IBD5 CHI3L1 19259344 3231593 Negative_regulation IBD5 FAS 25045210 1760144 Negative_regulation IBD5 IL1B 23915129 359241 Negative_regulation IBD5 NT5E 23118501 1225290 Negative_regulation IBD5 TNF 10562322 1513164 Negative_regulation IBD5 TNF 12625840 312761 Negative_regulation IBD5 TNF 15694007 391932 Negative_regulation IBD5 TNF 16259632 1624810 Negative_regulation IBD5 TNF 21853060 2542951 Negative_regulation IBD5 TNF 24339869 2891298 Negative_regulation IBD6 CD14 23730203 679421 Negative_regulation IBD6 CHI3L1 19259344 3231594 Negative_regulation IBD6 FAS 25045210 1760146 Negative_regulation IBD6 IL1B 23915129 359243 Negative_regulation IBD6 NT5E 23118501 1225291 Negative_regulation IBD6 TNF 10562322 1513165 Negative_regulation IBD6 TNF 12625840 312762 Negative_regulation IBD6 TNF 15694007 391933 Negative_regulation IBD6 TNF 16259632 1624811 Negative_regulation IBD6 TNF 21853060 2542952 Negative_regulation IBD6 TNF 24339869 2891299 Negative_regulation IBD7 CD14 23730203 679415 Negative_regulation IBD7 CHI3L1 19259344 3231588 Negative_regulation IBD7 FAS 25045210 1760134 Negative_regulation IBD7 IL1B 23915129 359231 Negative_regulation IBD7 NT5E 23118501 1225285 Negative_regulation IBD7 TNF 10562322 1513159 Negative_regulation IBD7 TNF 12625840 312756 Negative_regulation IBD7 TNF 15694007 391927 Negative_regulation IBD7 TNF 16259632 1624805 Negative_regulation IBD7 TNF 21853060 2542946 Negative_regulation IBD7 TNF 24339869 2891293 Negative_regulation IBD8 CD14 23730203 679416 Negative_regulation IBD8 CHI3L1 19259344 3231589 Negative_regulation IBD8 FAS 25045210 1760136 Negative_regulation IBD8 IL1B 23915129 359233 Negative_regulation IBD8 NT5E 23118501 1225286 Negative_regulation IBD8 TNF 10562322 1513160 Negative_regulation IBD8 TNF 12625840 312757 Negative_regulation IBD8 TNF 15694007 391928 Negative_regulation IBD8 TNF 16259632 1624806 Negative_regulation IBD8 TNF 21853060 2542947 Negative_regulation IBD8 TNF 24339869 2891294 Negative_regulation IBD9 CD14 23730203 679417 Negative_regulation IBD9 CHI3L1 19259344 3231590 Negative_regulation IBD9 FAS 25045210 1760138 Negative_regulation IBD9 IL1B 23915129 359235 Negative_regulation IBD9 NT5E 23118501 1225287 Negative_regulation IBD9 TNF 10562322 1513161 Negative_regulation IBD9 TNF 12625840 312758 Negative_regulation IBD9 TNF 15694007 391929 Negative_regulation IBD9 TNF 16259632 1624807 Negative_regulation IBD9 TNF 21853060 2542948 Negative_regulation IBD9 TNF 24339869 2891295 Negative_regulation ICAM1 ANGPT1 19435476 659214 Negative_regulation ICAM1 EPHB2 23098564 1231463 Negative_regulation ICAM1 HES2 24891765 1759460 Negative_regulation ICAM1 HES2 24891765 1759504 Negative_regulation ICAM1 ITGAL 25132734 1760500 Negative_regulation ICAM1 ITGAL 7680657 1438756 Negative_regulation ICAM1 ITGAL 7680657 1438757 Negative_regulation ICAM1 ITGB2 17078873 3116396 Negative_regulation ICAM1 ITGB2 20161849 1043915 Negative_regulation ICAM1 ITGB2 23097741 1728572 Negative_regulation ICAM1 PECAM1 18466611 392138 Negative_regulation ICAM1 SELL 21655059 1635371 Negative_regulation ICAM1 TNF 11532196 368605 Negative_regulation ICAM1 TNF 12003644 312745 Negative_regulation ICAM1 TNF 16104828 2368421 Negative_regulation ICAM1 TNF 21269478 508404 Negative_regulation ICAM1 TNF 21375761 1697084 Negative_regulation ICAM1 TNF 21808585 1682046 Negative_regulation ICAM1 TNF 22111033 730305 Negative_regulation ICAM1 TNF 22536886 291996 Negative_regulation ICAM1 TNF 22754320 1095962 Negative_regulation ICAM1 TNF 23130331 135991 Negative_regulation ICAM1 TNF 23136554 1060883 Negative_regulation ICAM1 TNF 23285282 2733425 Negative_regulation ICAM1 TNF 23285282 2733427 Negative_regulation ICAM1 TNF 23317476 1155714 Negative_regulation ICAM1 TNF 23671702 2792482 Negative_regulation ICAM1 TNF 23929007 87357 Negative_regulation ICAM1 TNF 24255667 843871 Negative_regulation ICAM1 TNF 24502696 1232949 Negative_regulation ICAM1 TNF 24649404 853722 Negative_regulation ICAM1 TNF 24884532 1701707 Negative_regulation ICAM1 TNF 25032222 194857 Negative_regulation ICAM1 TNF 25329155 3015908 Negative_regulation ICAM1 TNF 25541965 3035959 Negative_regulation ICAM1 TNF 25552899 743683 Negative_regulation ICAM1 TNF 7577463 444044 Negative_regulation ICAM1 TNF 7908214 444475 Negative_regulation ICAM1 TNF 9374368 446669 Negative_regulation ICAM2 ITGB2 24317296 1487269 Negative_regulation ICR1 TNF 6386027 443699 Negative_regulation ICR3 TNF 6386027 443700 Negative_regulation ICR4 TNF 6386027 443701 Negative_regulation ICR5 TNF 6386027 443702 Negative_regulation ID1 ACKR3 24256728 1991158 Negative_regulation ID1 ACVR1 23593444 2781393 Negative_regulation ID1 ATF3 20565867 1856217 Negative_regulation ID1 BMPR1A 22916109 2680013 Negative_regulation ID1 BMPR1A 23593444 2781392 Negative_regulation ID1 CCNA2 22139302 1879379 Negative_regulation ID1 CCNA2 22139302 1879431 Negative_regulation ID1 CCNA2 22139302 1879443 Negative_regulation ID1 DLL4 23531541 1103861 Negative_regulation ID1 DLX4 21297662 2137908 Negative_regulation ID1 FGF2 24256728 1991159 Negative_regulation ID1 FOXO3 20565867 1856202 Negative_regulation ID1 FOXO3 20565867 1856225 Negative_regulation ID1 FOXO3 20565867 1856254 Negative_regulation ID1 FOXO3 23259070 1719144 Negative_regulation ID1 INHBA 22082494 1643476 Negative_regulation ID1 INS 21940780 720685 Negative_regulation ID1 JAK1 17908914 1345072 Negative_regulation ID1 KLF17 19951400 1006920 Negative_regulation ID1 KLF17 19951400 1006922 Negative_regulation ID1 KLF17 19951400 1006924 Negative_regulation ID1 KLF17 21293053 2174738 Negative_regulation ID1 MIR381 25078608 2993650 Negative_regulation ID1 MYLIP 23802096 945534 Negative_regulation ID1 MYLIP 23991130 2841130 Negative_regulation ID1 NOG 25010525 3068625 Negative_regulation ID1 NOTCH1 22393458 2608285 Negative_regulation ID1 NOTCH1 24950189 2982097 Negative_regulation ID1 PTGS2 24659686 2188434 Negative_regulation ID1 SLC22A3 24687377 477588 Negative_regulation ID1 SMAD3 20565867 1856095 Negative_regulation ID1 SYCP2 22130070 553590 Negative_regulation ID1 TCF12 21765909 2536215 Negative_regulation ID1 TCF15 21765909 2536216 Negative_regulation ID1 TCF19 21765909 2536217 Negative_regulation ID1 TCF20 21765909 2536218 Negative_regulation ID1 TCF21 21765909 2536219 Negative_regulation ID1 TCF23 21765909 2536223 Negative_regulation ID1 TCF24 21765909 2536225 Negative_regulation ID1 TCF25 21765909 2536224 Negative_regulation ID1 TCF3 18489764 352173 Negative_regulation ID1 TCF3 21765909 2536220 Negative_regulation ID1 TCF4 21765909 2536221 Negative_regulation ID1 TCF7 21765909 2536222 Negative_regulation ID1 TGFB1I1 21996749 2143772 Negative_regulation ID1 TGFB1I1 21996749 2144125 Negative_regulation ID1 THOC5 24157873 568501 Negative_regulation ID1 TNF 23531541 1103860 Negative_regulation ID1 TNFAIP1 18315846 234228 Negative_regulation ID1 VEGFA 24256728 1991157 Negative_regulation ID1 ZNF382 21876767 2547459 Negative_regulation ID2 CDKN1C 19417068 2043694 Negative_regulation ID2 CDKN1C 19417068 2043698 Negative_regulation ID2 MMP7 16959035 249723 Negative_regulation ID3 EPHB2 11560990 1520818 Negative_regulation IDDM10 TNF 8920849 1599282 Negative_regulation IDDM11 TNF 8920849 1599283 Negative_regulation IDDM12 TNF 8920849 1599284 Negative_regulation IDDM13 TNF 8920849 1599285 Negative_regulation IDDM14 TNF 8920849 1599286 Negative_regulation IDDM15 TNF 8920849 1599287 Negative_regulation IDDM16 TNF 8920849 1599288 Negative_regulation IDDM17 TNF 8920849 1599289 Negative_regulation IDDM18 TNF 8920849 1599290 Negative_regulation IDDM2 TNF 8920849 1599291 Negative_regulation IDDM3 TNF 8920849 1599292 Negative_regulation IDDM4 TNF 8920849 1599293 Negative_regulation IDDM5 TNF 8920849 1599294 Negative_regulation IDDM6 TNF 8920849 1599295 Negative_regulation IDDM7 TNF 8920849 1599296 Negative_regulation IDDM8 TNF 8920849 1599297 Negative_regulation IDDM9 TNF 8920849 1599298 Negative_regulation IDE TNF 24740421 2954826 Negative_regulation IDH3A PGC 19435887 1165956 Negative_regulation IDH3B PGC 19435887 1165957 Negative_regulation IDH3G PGC 19435887 1165958 Negative_regulation IDO1 TLR7 22708060 4552 Negative_regulation IDO1 TNF 23924945 1109763 Negative_regulation IDO1 TNF 25123797 368542 Negative_regulation IDO2 TNF 23924945 1109762 Negative_regulation IFI16 TNF 19121222 112341 Negative_regulation IFI27 ABL1 24098519 2857985 Negative_regulation IFI27 AKT1 12057025 248242 Negative_regulation IFI27 AKT1 16780593 579925 Negative_regulation IFI27 AKT1 16780593 579945 Negative_regulation IFI27 AKT1 21266327 717074 Negative_regulation IFI27 AKT1 21297943 2498585 Negative_regulation IFI27 AKT1 22654768 957205 Negative_regulation IFI27 AKT1 22733130 2147645 Negative_regulation IFI27 AKT1 23232026 2181984 Negative_regulation IFI27 AKT1 23300741 2735789 Negative_regulation IFI27 AKT1 23471028 1637691 Negative_regulation IFI27 AKT1 23511556 440362 Negative_regulation IFI27 AKT1 25247710 3009196 Negative_regulation IFI27 AKT2 12057025 248243 Negative_regulation IFI27 AKT2 16780593 579926 Negative_regulation IFI27 AKT2 16780593 579946 Negative_regulation IFI27 AKT2 21266327 717075 Negative_regulation IFI27 AKT2 21297943 2498586 Negative_regulation IFI27 AKT2 22654768 957206 Negative_regulation IFI27 AKT2 22733130 2147646 Negative_regulation IFI27 AKT2 23232026 2181985 Negative_regulation IFI27 AKT2 23300741 2735790 Negative_regulation IFI27 AKT2 23471028 1637692 Negative_regulation IFI27 AKT2 23511556 440363 Negative_regulation IFI27 AKT2 25247710 3009197 Negative_regulation IFI27 AKT3 12057025 248244 Negative_regulation IFI27 AKT3 16780593 579927 Negative_regulation IFI27 AKT3 16780593 579947 Negative_regulation IFI27 AKT3 21266327 717076 Negative_regulation IFI27 AKT3 21297943 2498587 Negative_regulation IFI27 AKT3 22654768 957207 Negative_regulation IFI27 AKT3 22733130 2147647 Negative_regulation IFI27 AKT3 23232026 2181986 Negative_regulation IFI27 AKT3 23300741 2735791 Negative_regulation IFI27 AKT3 23471028 1637693 Negative_regulation IFI27 AKT3 23511556 440364 Negative_regulation IFI27 AKT3 25247710 3009198 Negative_regulation IFI27 APOBEC3G 23890083 378393 Negative_regulation IFI27 APOBEC3G 23890083 378435 Negative_regulation IFI27 BCR 24098519 2857983 Negative_regulation IFI27 BLM 24811221 2190597 Negative_regulation IFI27 BTRC 24502434 833959 Negative_regulation IFI27 CAND1 21119001 1784001 Negative_regulation IFI27 CASP1 21153858 1148041 Negative_regulation IFI27 CASP10 21153858 1148042 Negative_regulation IFI27 CASP12 21153858 1148052 Negative_regulation IFI27 CASP14 21153858 1148043 Negative_regulation IFI27 CASP16 21153858 1148053 Negative_regulation IFI27 CASP2 21153858 1148044 Negative_regulation IFI27 CASP3 21153858 1148045 Negative_regulation IFI27 CASP4 21153858 1148046 Negative_regulation IFI27 CASP5 21153858 1148047 Negative_regulation IFI27 CASP6 21153858 1148048 Negative_regulation IFI27 CASP7 21153858 1148049 Negative_regulation IFI27 CASP8 21153858 1148050 Negative_regulation IFI27 CASP9 21153858 1148051 Negative_regulation IFI27 CCNA2 18544709 706263 Negative_regulation IFI27 CCNA2 23071750 2703993 Negative_regulation IFI27 CCND1 17296798 1337105 Negative_regulation IFI27 CCND1 19115995 1503530 Negative_regulation IFI27 CCND1 20119532 672378 Negative_regulation IFI27 CCND1 20824095 2473726 Negative_regulation IFI27 CCND1 21209944 2492515 Negative_regulation IFI27 CCND1 23549262 1104724 Negative_regulation IFI27 CCND1 24006921 269674 Negative_regulation IFI27 CCND2 18382684 2387477 Negative_regulation IFI27 CCND3 18382684 2387478 Negative_regulation IFI27 CCNE1 20876711 716609 Negative_regulation IFI27 CDK2 20876711 716610 Negative_regulation IFI27 CDK2 21197465 3127810 Negative_regulation IFI27 CDK2 21423803 2508391 Negative_regulation IFI27 CDK2 21526108 1685640 Negative_regulation IFI27 CDK2 23071750 2703994 Negative_regulation IFI27 CDK2 25032860 577612 Negative_regulation IFI27 CDK2 25114575 2123256 Negative_regulation IFI27 CDK4 17092340 580222 Negative_regulation IFI27 CDKN1A 23801714 727616 Negative_regulation IFI27 CDKN1B 25053875 1917167 Negative_regulation IFI27 CIB1 19669214 1619247 Negative_regulation IFI27 CKS1B 22898779 700291 Negative_regulation IFI27 CKS1B 23029392 2697132 Negative_regulation IFI27 CNR1 21346174 717967 Negative_regulation IFI27 COMMD5 24515317 1652173 Negative_regulation IFI27 CPE 24006921 269675 Negative_regulation IFI27 CUL1 24502434 833960 Negative_regulation IFI27 DDX58 24727952 2951768 Negative_regulation IFI27 EFNB3 23303128 558838 Negative_regulation IFI27 EGF 23919615 290078 Negative_regulation IFI27 EGFR 20200561 1719548 Negative_regulation IFI27 ELF1 19672456 1213031 Negative_regulation IFI27 ELF2 19672456 1213032 Negative_regulation IFI27 ELF3 19672456 1213033 Negative_regulation IFI27 ELF4 19672456 1213034 Negative_regulation IFI27 ELF5 19672456 1213035 Negative_regulation IFI27 EPHB2 21904669 798919 Negative_regulation IFI27 EPHB2 23237773 2181996 Negative_regulation IFI27 ESR1 23351343 695275 Negative_regulation IFI27 EVPL 24098519 2857984 Negative_regulation IFI27 EZH2 25431950 2207374 Negative_regulation IFI27 FOXM1 20187950 1853653 Negative_regulation IFI27 FOXM1 23006512 1698858 Negative_regulation IFI27 FOXO3 11815629 1278645 Negative_regulation IFI27 FOXO3 19384426 668856 Negative_regulation IFI27 GADD45G 24820829 1045920 Negative_regulation IFI27 HDAC1 15033603 792088 Negative_regulation IFI27 HDAC1 15040315 792096 Negative_regulation IFI27 HDAC1 15040317 792104 Negative_regulation IFI27 HDAC1 24116279 204295 Negative_regulation IFI27 HDAC2 15033603 792089 Negative_regulation IFI27 HDAC2 15040315 792097 Negative_regulation IFI27 HDAC2 15040317 792105 Negative_regulation IFI27 HDAC2 24116279 204296 Negative_regulation IFI27 HDAC5 24346863 1065563 Negative_regulation IFI27 HNRNPU 19015320 1361621 Negative_regulation IFI27 HOXA9 23589697 2121208 Negative_regulation IFI27 ID1 23342268 491923 Negative_regulation IFI27 ID3 18069898 2304625 Negative_regulation IFI27 ID3 18069898 2304641 Negative_regulation IFI27 ID3 18069898 2304650 Negative_regulation IFI27 ID3 18069898 2304654 Negative_regulation IFI27 ID3 23342268 491924 Negative_regulation IFI27 IKBKE 23691078 2794280 Negative_regulation IFI27 IKBKE 23691078 2794296 Negative_regulation IFI27 IL8 25165728 1623140 Negative_regulation IFI27 INS 23896637 1150420 Negative_regulation IFI27 IRF4 23243601 2161930 Negative_regulation IFI27 LCK 18069898 2304626 Negative_regulation IFI27 LCK 18069898 2304644 Negative_regulation IFI27 LCK 18069898 2304651 Negative_regulation IFI27 LGALS3 24971481 548989 Negative_regulation IFI27 LGALS3 24971481 549035 Negative_regulation IFI27 MAP2K1 19015320 1361622 Negative_regulation IFI27 MAP2K2 19015320 1361623 Negative_regulation IFI27 MAP2K3 19015320 1361624 Negative_regulation IFI27 MAP2K4 19015320 1361625 Negative_regulation IFI27 MAP2K5 19015320 1361626 Negative_regulation IFI27 MAP2K6 19015320 1361627 Negative_regulation IFI27 MAP2K7 19015320 1361628 Negative_regulation IFI27 MAPK1 23762493 2804173 Negative_regulation IFI27 MAPK10 23762493 2804174 Negative_regulation IFI27 MAPK11 23762493 2804175 Negative_regulation IFI27 MAPK12 23762493 2804176 Negative_regulation IFI27 MAPK13 23762493 2804177 Negative_regulation IFI27 MAPK14 23762493 2804178 Negative_regulation IFI27 MAPK15 23762493 2804172 Negative_regulation IFI27 MAPK3 23762493 2804179 Negative_regulation IFI27 MAPK4 23762493 2804180 Negative_regulation IFI27 MAPK6 23762493 2804181 Negative_regulation IFI27 MAPK7 23762493 2804182 Negative_regulation IFI27 MAPK8 23762493 2804183 Negative_regulation IFI27 MAPK9 23762493 2804184 Negative_regulation IFI27 MIR221 22432036 2611728 Negative_regulation IFI27 MIR296 21461395 1673113 Negative_regulation IFI27 MTOR 20576128 256486 Negative_regulation IFI27 MTOR 21909123 13346 Negative_regulation IFI27 MTOR 23300741 2735792 Negative_regulation IFI27 MYC 19707334 175471 Negative_regulation IFI27 MYC 20426839 1854565 Negative_regulation IFI27 MYLIP 19107213 2402732 Negative_regulation IFI27 MYLIP 21552422 1057207 Negative_regulation IFI27 MYLIP 21645299 395471 Negative_regulation IFI27 MYLIP 22065734 514312 Negative_regulation IFI27 MYLIP 23074383 1239702 Negative_regulation IFI27 MYLIP 23890083 378436 Negative_regulation IFI27 MYLIP 23890083 378444 Negative_regulation IFI27 MYLIP 24137356 2165639 Negative_regulation IFI27 MYLIP 24662606 3223806 Negative_regulation IFI27 MYLIP 24727952 2951764 Negative_regulation IFI27 MYLIP 24727952 2951766 Negative_regulation IFI27 MYLIP 24727952 2951767 Negative_regulation IFI27 MYLIP 24970806 2193914 Negative_regulation IFI27 PARP1 24367566 2900225 Negative_regulation IFI27 PARP1 24367566 2900240 Negative_regulation IFI27 PAX3 PMC2364207 449978 Negative_regulation IFI27 PDGFB 21892199 13279 Negative_regulation IFI27 PDK1 23300741 2735793 Negative_regulation IFI27 PFKFB3 25032860 577590 Negative_regulation IFI27 PFKFB3 25032860 577591 Negative_regulation IFI27 PFKFB3 25032860 577592 Negative_regulation IFI27 PI3 20200561 1719456 Negative_regulation IFI27 PIK3CA 22733130 2147454 Negative_regulation IFI27 PIK3CA 22733130 2147648 Negative_regulation IFI27 PIK3CA 25247710 3009190 Negative_regulation IFI27 PIK3CA 9679152 1469041 Negative_regulation IFI27 PIK3R1 22733130 2147455 Negative_regulation IFI27 PIK3R1 22733130 2147649 Negative_regulation IFI27 PIK3R1 25247710 3009191 Negative_regulation IFI27 PIK3R1 9679152 1469042 Negative_regulation IFI27 POLDIP2 22404972 528390 Negative_regulation IFI27 PRKAA1 20170512 481467 Negative_regulation IFI27 PRKAA2 20170512 481468 Negative_regulation IFI27 PRKAB1 20170512 481469 Negative_regulation IFI27 PRKAB2 20170512 481470 Negative_regulation IFI27 PRKAG1 20170512 481471 Negative_regulation IFI27 PRKAG2 20170512 481472 Negative_regulation IFI27 PRMT6 22916108 2680000 Negative_regulation IFI27 PTBP1 24457952 571256 Negative_regulation IFI27 PTK7 24587299 2929238 Negative_regulation IFI27 RAD1 25061503 987032 Negative_regulation IFI27 RAD17 25061503 987033 Negative_regulation IFI27 RAD18 25061503 987031 Negative_regulation IFI27 RAD21 25061503 987034 Negative_regulation IFI27 RAD50 25061503 987035 Negative_regulation IFI27 RAD51 25061503 987036 Negative_regulation IFI27 RAD52 25061503 987037 Negative_regulation IFI27 RALA 23576547 1813471 Negative_regulation IFI27 RALB 23576547 1813472 Negative_regulation IFI27 RB1 24632684 1941047 Negative_regulation IFI27 RBBP4 15033603 792090 Negative_regulation IFI27 RBBP4 15040315 792098 Negative_regulation IFI27 RBBP4 15040317 792106 Negative_regulation IFI27 RBBP4 24116279 204297 Negative_regulation IFI27 RBBP7 15033603 792091 Negative_regulation IFI27 RBBP7 15040315 792099 Negative_regulation IFI27 RBBP7 15040317 792107 Negative_regulation IFI27 RBBP7 24116279 204298 Negative_regulation IFI27 REST 22665064 2147195 Negative_regulation IFI27 RHOA 25452716 872530 Negative_regulation IFI27 RPTOR 20576128 256485 Negative_regulation IFI27 RUNX2 21197465 3127809 Negative_regulation IFI27 SETD2 23203043 1099497 Negative_regulation IFI27 SF3B3 23951410 170566 Negative_regulation IFI27 SF3B3 23951410 170603 Negative_regulation IFI27 SIRT1 16596166 2302282 Negative_regulation IFI27 SKP1 24502434 833958 Negative_regulation IFI27 SKP2 12188931 277021 Negative_regulation IFI27 SKP2 12188931 277048 Negative_regulation IFI27 SKP2 15631990 1317544 Negative_regulation IFI27 SKP2 17088910 428335 Negative_regulation IFI27 SKP2 17296798 1337104 Negative_regulation IFI27 SKP2 19356250 3117717 Negative_regulation IFI27 SKP2 22279619 939642 Negative_regulation IFI27 SKP2 23029392 2697058 Negative_regulation IFI27 SKP2 23029392 2697131 Negative_regulation IFI27 SKP2 23437233 2756274 Negative_regulation IFI27 SKP2 24971481 548988 Negative_regulation IFI27 SP1 25099028 1702429 Negative_regulation IFI27 SRC 20200561 1719547 Negative_regulation IFI27 STAT3 23549262 1104723 Negative_regulation IFI27 STAT3 25412315 579354 Negative_regulation IFI27 STAT6 24401087 271080 Negative_regulation IFI27 SUMO1 18025037 2031598 Negative_regulation IFI27 TM4SF5 22427965 2610811 Negative_regulation IFI27 TMED7 17088910 428350 Negative_regulation IFI27 TMED7 25099287 3144976 Negative_regulation IFI27 TNF 19121222 112342 Negative_regulation IFI27 TOB1 20513747 1558427 Negative_regulation IFI27 TOB1 22710759 1140918 Negative_regulation IFI27 TP53 23230003 1570425 Negative_regulation IFI27 UCA1 24457952 571254 Negative_regulation IFI27 UCA1 24457952 571255 Negative_regulation IFI27 ULK1 21999842 1863708 Negative_regulation IFI27 ZNF703 21328542 775875 Negative_regulation IFI30 TNF 19121222 112343 Negative_regulation IFI35 TNF 19121222 112344 Negative_regulation IFI44 EPHB2 20090934 2437589 Negative_regulation IFI44 MIP 17233909 351840 Negative_regulation IFI44 NES 23145110 2715777 Negative_regulation IFI44 RGS2 18067675 461926 Negative_regulation IFI44 TNF 19121222 112339 Negative_regulation IFI6 TNF 19121222 112340 Negative_regulation IFN1@ OASL 23874199 3063130 Negative_regulation IFN1@ OASL 23874199 3063144 Negative_regulation IFN1@ OASL 23874199 3063146 Negative_regulation IFN1@ TLR7 21994626 3219451 Negative_regulation IFN1@ TLR7 22279442 923951 Negative_regulation IFN1@ TNF 20504321 3213162 Negative_regulation IFN1@ TNF 3110354 1580011 Negative_regulation IFNA1 ADRB2 23724117 2799021 Negative_regulation IFNA1 ADRB2 23724117 2799029 Negative_regulation IFNA1 ADRB2 23724117 2799034 Negative_regulation IFNAR1 TNF 21365015 2504970 Negative_regulation IFNB1 EPHB2 22427889 2610559 Negative_regulation IFNB1 EPHB2 22427889 2610582 Negative_regulation IFNB1 NEDD9 22427889 2610551 Negative_regulation IFNB1 NEDD9 22427889 2610552 Negative_regulation IFNB1 NEDD9 22427889 2610587 Negative_regulation IFNG ANGPT1 23171759 660383 Negative_regulation IFNG IL1B PMC4081846 651839 Negative_regulation IFNG TNF PMC4081846 651838 Negative_regulation IGF1 CDKN1C 17517131 300012 Negative_regulation IGF1 CDKN1C 17517131 300013 Negative_regulation IGF1 EPHB2 22289259 124704 Negative_regulation IGF1 FOXO1 19043554 2306899 Negative_regulation IGF1 FOXO1 23614736 829932 Negative_regulation IGF1 FOXO1 23614736 830024 Negative_regulation IGF1 FOXO1 24949430 192596 Negative_regulation IGF1 IGFBP1 12793901 457723 Negative_regulation IGF1 IGFBP1 17201918 460634 Negative_regulation IGF1 IGFBP1 21331285 1669726 Negative_regulation IGF1 IGFBP1 22291478 639652 Negative_regulation IGF1 IGFBP1 23650566 2789117 Negative_regulation IGF1 IGFBP1 23761784 878692 Negative_regulation IGF1 IGFBP1 23970935 822341 Negative_regulation IGF1 IGFBP1 23983688 1073736 Negative_regulation IGF1 IGFBP1 24558395 2923561 Negative_regulation IGF1 IGFBP1 24647478 2936184 Negative_regulation IGF1 IGFBP1 24790301 650037 Negative_regulation IGF1 IGFBP1 24887156 1508088 Negative_regulation IGF1 MAP2K6 19834495 546466 Negative_regulation IGF1 MAP2K6 21699731 1862519 Negative_regulation IGF1 MAP2K6 21699731 1862539 Negative_regulation IGF1 PGC 25136584 197216 Negative_regulation IGF1 RAB31 19460165 253343 Negative_regulation IGF1 TNF 14624679 658499 Negative_regulation IGF1 TNF 22207907 1238539 Negative_regulation IGF1 TNF 22246875 1920541 Negative_regulation IGF1 TNF 24381559 963197 Negative_regulation IGF1 TNF 25141822 1736215 Negative_regulation IGF1 TNFSF10 23091403 3129171 Negative_regulation IGF1R IGFBP1 23994953 3136915 Negative_regulation IGF1R TM4SF19 25344917 2206144 Negative_regulation IGF1R TM4SF19 25344917 2206315 Negative_regulation IGF2 FOXO1 19043554 2306904 Negative_regulation IGF2 FOXO1 24949430 192600 Negative_regulation IGF2 IGFBP1 12793901 457730 Negative_regulation IGF2 IGFBP1 23970935 822348 Negative_regulation IGF2 IGFBP1 23983688 1073744 Negative_regulation IGF2 IGFBP1 24647478 2936185 Negative_regulation IGFALS IGFBP1 23761784 878693 Negative_regulation IGFALS PGC 18464922 3072309 Negative_regulation IGFALS TNF 20195368 2441793 Negative_regulation IGFBP1 AKT1 23614736 830028 Negative_regulation IGFBP1 AKT1 24036443 1112501 Negative_regulation IGFBP1 AKT2 23614736 830029 Negative_regulation IGFBP1 AKT2 24036443 1112502 Negative_regulation IGFBP1 AKT3 23614736 830030 Negative_regulation IGFBP1 AKT3 24036443 1112503 Negative_regulation IGFBP1 CASP8 18221535 1003352 Negative_regulation IGFBP1 GLI3 24548465 539452 Negative_regulation IGFBP1 GLI3 24548465 539458 Negative_regulation IGFBP1 HCFC1 21909281 2326255 Negative_regulation IGFBP1 HES1 25397403 3027115 Negative_regulation IGFBP1 HMGA1 22355763 3130420 Negative_regulation IGFBP1 HMGA1 22355763 3130430 Negative_regulation IGFBP1 HOXA10 21814398 1636508 Negative_regulation IGFBP1 IFI16 18221535 1003375 Negative_regulation IGFBP1 IGF1 14668044 830324 Negative_regulation IGFBP1 IGF1 23761784 878695 Negative_regulation IGFBP1 IGF1 24887156 1508089 Negative_regulation IGFBP1 IGF2 14668044 830325 Negative_regulation IGFBP1 IGFALS 23761784 878696 Negative_regulation IGFBP1 IGFBP7 23028860 2693460 Negative_regulation IGFBP1 IL1A 21801462 3101310 Negative_regulation IGFBP1 INS 14668045 830414 Negative_regulation IGFBP1 INS 14668047 830496 Negative_regulation IGFBP1 INS 17953765 308406 Negative_regulation IGFBP1 INS 18234122 3096604 Negative_regulation IGFBP1 INS 18234122 3096605 Negative_regulation IGFBP1 INS 18234122 3096606 Negative_regulation IGFBP1 INS 18234122 3096620 Negative_regulation IGFBP1 INS 18234122 3096621 Negative_regulation IGFBP1 INS 18234122 3096627 Negative_regulation IGFBP1 INS 20216949 1489790 Negative_regulation IGFBP1 INS 20216949 1489867 Negative_regulation IGFBP1 INS 22237688 733520 Negative_regulation IGFBP1 INS 23186039 2113611 Negative_regulation IGFBP1 INS 23401790 1151205 Negative_regulation IGFBP1 INS 23557110 381297 Negative_regulation IGFBP1 INS 23557110 381298 Negative_regulation IGFBP1 INS 23557110 381303 Negative_regulation IGFBP1 INS 23668396 731824 Negative_regulation IGFBP1 INS 24386010 745868 Negative_regulation IGFBP1 INS 25309512 881195 Negative_regulation IGFBP1 INS 9662244 447291 Negative_regulation IGFBP1 INS PMC4088532 661278 Negative_regulation IGFBP1 MED1 18221535 1003377 Negative_regulation IGFBP1 MED10 18221535 1003371 Negative_regulation IGFBP1 MED11 18221535 1003374 Negative_regulation IGFBP1 MED13 18221535 1003358 Negative_regulation IGFBP1 MED13L 18221535 1003359 Negative_regulation IGFBP1 MED14 18221535 1003363 Negative_regulation IGFBP1 MED15 18221535 1003351 Negative_regulation IGFBP1 MED16 18221535 1003354 Negative_regulation IGFBP1 MED17 18221535 1003365 Negative_regulation IGFBP1 MED18 18221535 1003370 Negative_regulation IGFBP1 MED19 18221535 1003373 Negative_regulation IGFBP1 MED20 18221535 1003353 Negative_regulation IGFBP1 MED21 18221535 1003349 Negative_regulation IGFBP1 MED22 18221535 1003350 Negative_regulation IGFBP1 MED23 18221535 1003364 Negative_regulation IGFBP1 MED24 18221535 1003360 Negative_regulation IGFBP1 MED25 18221535 1003372 Negative_regulation IGFBP1 MED26 18221535 1003366 Negative_regulation IGFBP1 MED27 18221535 1003367 Negative_regulation IGFBP1 MED29 18221535 1003362 Negative_regulation IGFBP1 MED30 18221535 1003361 Negative_regulation IGFBP1 MED31 18221535 1003369 Negative_regulation IGFBP1 MED4 18221535 1003355 Negative_regulation IGFBP1 MED6 18221535 1003356 Negative_regulation IGFBP1 MED7 18221535 1003368 Negative_regulation IGFBP1 MED8 18221535 1003357 Negative_regulation IGFBP1 NOTCH1 25397403 3027116 Negative_regulation IGFBP1 NOTCH2 25397403 3027117 Negative_regulation IGFBP1 NOTCH3 25397403 3027118 Negative_regulation IGFBP1 NOTCH4 25397403 3027119 Negative_regulation IGFBP1 OPA1 18221535 1003376 Negative_regulation IGFBP1 PIK3CA 24036443 1112504 Negative_regulation IGFBP1 PIK3R1 24036443 1112505 Negative_regulation IGFBP1 SIRT1 17201918 460636 Negative_regulation IGFBP1 SIRT6 23075334 651622 Negative_regulation IGFBP1 STAT5B 23761784 878694 Negative_regulation IGFBP1 TIMP2 25289643 3012519 Negative_regulation IGFBP1 TP53 22674894 778741 Negative_regulation IGFBP2 IGFBP1 19840988 1035487 Negative_regulation IGFBP3 FOXA1 22879989 2673437 Negative_regulation IGFBP3 TNF 23383064 2747715 Negative_regulation IGFBP7 IGFBP1 23028860 2693461 Negative_regulation IGH ID1 8045940 1444365 Negative_regulation IGKV1-27 TNF 22958952 1920501 Negative_regulation IHH EPHB2 25003010 3092913 Negative_regulation IKBKB EPHB2 22536447 2622530 Negative_regulation IKBKB MAP2K6 22536447 2622536 Negative_regulation IKBKB MAP2K6 23826126 2810291 Negative_regulation IKBKB MMP28 22359588 2598049 Negative_regulation IKBKB MMP7 22359588 2598065 Negative_regulation IKBKB TNF 10359587 1511932 Negative_regulation IKBKB TNF 22046421 2567710 Negative_regulation IKBKB TNF 22351606 778111 Negative_regulation IKBKB TNFSF10 20977779 257736 Negative_regulation IKBKG EPHB2 22536447 2622538 Negative_regulation IKBKG MAP2K6 22536447 2622544 Negative_regulation IKBKG MAP2K6 23826126 2810298 Negative_regulation IKBKG MMP28 22359588 2598072 Negative_regulation IKBKG MMP7 22359588 2598088 Negative_regulation IKBKG TNF 10359587 1511934 Negative_regulation IKBKG TNF 16754954 1330287 Negative_regulation IKBKG TNF 22046421 2567712 Negative_regulation IKBKG TNF 22351606 778112 Negative_regulation IKBKG TNFSF10 20977779 257738 Negative_regulation IL10 ANGPT1 23036162 660340 Negative_regulation IL10 ANGPT1 23036162 660348 Negative_regulation IL10 ANGPT1 23171759 660384 Negative_regulation IL10 ARSA 21196646 3129477 Negative_regulation IL10 CD14 12391013 1525086 Negative_regulation IL10 CD14 17242961 810091 Negative_regulation IL10 CD14 20946675 1723251 Negative_regulation IL10 CD14 20946675 1723252 Negative_regulation IL10 CD14 20946675 1723305 Negative_regulation IL10 CST6 25275395 2372992 Negative_regulation IL10 EPHB2 18648505 2393011 Negative_regulation IL10 EPHB2 19667062 1555662 Negative_regulation IL10 EPHB2 20008527 1556956 Negative_regulation IL10 EPHB2 23104131 1962446 Negative_regulation IL10 EPHB2 24855454 1627894 Negative_regulation IL10 EPHB2 25166426 3003722 Negative_regulation IL10 FAS 9730890 1603534 Negative_regulation IL10 FAS 9730890 1603535 Negative_regulation IL10 FOXO1 19651810 710744 Negative_regulation IL10 FOXO1 24864265 191796 Negative_regulation IL10 MAOA 22747645 358576 Negative_regulation IL10 PLAT 3491174 1583127 Negative_regulation IL10 TLR7 20625435 2455098 Negative_regulation IL10 TLR7 21188217 1081600 Negative_regulation IL10 TLR7 22808181 2665011 Negative_regulation IL10 TLR7 22928050 2681704 Negative_regulation IL10 TLR7 25083184 1078058 Negative_regulation IL10 TLR7 25309919 201116 Negative_regulation IL10 TLR7 25368611 914922 Negative_regulation IL10 TNF 10408703 414813 Negative_regulation IL10 TNF 10408703 414814 Negative_regulation IL10 TNF 10408703 414815 Negative_regulation IL10 TNF 11577995 1737879 Negative_regulation IL10 TNF 11879539 98623 Negative_regulation IL10 TNF 16275760 1538137 Negative_regulation IL10 TNF 16275760 1538138 Negative_regulation IL10 TNF 16275760 1538139 Negative_regulation IL10 TNF 16275760 1538212 Negative_regulation IL10 TNF 16432252 1539316 Negative_regulation IL10 TNF 16432252 1539317 Negative_regulation IL10 TNF 18179717 991657 Negative_regulation IL10 TNF 18442421 1043610 Negative_regulation IL10 TNF 20016738 2114382 Negative_regulation IL10 TNF 20380750 291245 Negative_regulation IL10 TNF 21291387 668405 Negative_regulation IL10 TNF 21339324 1562646 Negative_regulation IL10 TNF 21345239 1697080 Negative_regulation IL10 TNF 22470449 2614189 Negative_regulation IL10 TNF 22693523 636264 Negative_regulation IL10 TNF 22848391 2668612 Negative_regulation IL10 TNF 22851816 1750157 Negative_regulation IL10 TNF 23078757 660371 Negative_regulation IL10 TNF 23240012 2727476 Negative_regulation IL10 TNF 23284599 2218899 Negative_regulation IL10 TNF 23494519 952899 Negative_regulation IL10 TNF 23533313 1751851 Negative_regulation IL10 TNF 23675368 878474 Negative_regulation IL10 TNF 23861957 2821017 Negative_regulation IL10 TNF 24093616 248025 Negative_regulation IL10 TNF 24093616 248026 Negative_regulation IL10 TNF 24391353 1756475 Negative_regulation IL10 TNF 24492460 1940527 Negative_regulation IL10 TNF 24492460 1940529 Negative_regulation IL10 TNF 24614867 2933156 Negative_regulation IL10 TNF 24870587 2975232 Negative_regulation IL10 TNF 24886513 132332 Negative_regulation IL10 TNF 24926878 2979836 Negative_regulation IL10 TNF 24970341 1668295 Negative_regulation IL10 TNF 25066324 314712 Negative_regulation IL10 TNF 25152735 965859 Negative_regulation IL10 TNF 25184950 1129354 Negative_regulation IL10 TNF 7964475 1593470 Negative_regulation IL10 TNF PMC2377328 2003581 Negative_regulation IL11 ARSA 21196646 3129478 Negative_regulation IL11 PLAT 3491174 1583128 Negative_regulation IL11 TNF 20380750 291247 Negative_regulation IL12A ALOX5 23613965 2782915 Negative_regulation IL12A CD14 15841259 810589 Negative_regulation IL12A EPHB2 18648505 2393356 Negative_regulation IL12A EPHB2 19291703 807613 Negative_regulation IL12A EPHB2 19667062 1555663 Negative_regulation IL12A EPHB2 21935379 2555372 Negative_regulation IL12A EPHB2 22537317 355833 Negative_regulation IL12A EPHB2 22537317 355850 Negative_regulation IL12A EPHB2 23133361 2297562 Negative_regulation IL12A FUT4 25180025 1761914 Negative_regulation IL12A GPNMB 18402690 315294 Negative_regulation IL12A MAP2K6 18282094 3040958 Negative_regulation IL12A NES 19406170 1770204 Negative_regulation IL12A STAT4 10704465 1514539 Negative_regulation IL12A STAT4 23386861 883433 Negative_regulation IL12A TLR7 16365150 1538999 Negative_regulation IL12A TLR7 18584038 3072575 Negative_regulation IL12A TLR7 18584038 3072655 Negative_regulation IL12A TLR7 18584038 3072790 Negative_regulation IL12A TLR7 18584038 3072791 Negative_regulation IL12A TLR7 19770272 1556341 Negative_regulation IL12A TLR7 20379390 1214407 Negative_regulation IL12A TLR7 23421931 590890 Negative_regulation IL12A TLR7 23787171 1666812 Negative_regulation IL12A TLR7 23967307 2836000 Negative_regulation IL12A TLR7 24489947 2917024 Negative_regulation IL12A TNF 11157054 1518372 Negative_regulation IL12A TNF 12223112 99401 Negative_regulation IL12A TNF 14568984 1529236 Negative_regulation IL12A TNF 18817542 352443 Negative_regulation IL12A TNF 19946407 34366 Negative_regulation IL12A TNF 22547990 3152599 Negative_regulation IL12A TNF 22547990 3152600 Negative_regulation IL12A TNF 22547990 3152637 Negative_regulation IL12A TNF 23049677 2698842 Negative_regulation IL12A TNF 23205044 135862 Negative_regulation IL12A TNF 24586980 2928685 Negative_regulation IL12A TNF 7722441 1591779 Negative_regulation IL12A TNFSF10 15841259 810599 Negative_regulation IL12A TP63 8551218 1595620 Negative_regulation IL12B ALOX5 23613965 2782916 Negative_regulation IL12B CD14 15841259 810590 Negative_regulation IL12B EPHB2 18648505 2393357 Negative_regulation IL12B EPHB2 19291703 807614 Negative_regulation IL12B EPHB2 19667062 1555665 Negative_regulation IL12B EPHB2 21935379 2555375 Negative_regulation IL12B EPHB2 22427889 2610561 Negative_regulation IL12B EPHB2 22537317 355835 Negative_regulation IL12B EPHB2 22537317 355851 Negative_regulation IL12B EPHB2 23133361 2297563 Negative_regulation IL12B FUT4 25180025 1761925 Negative_regulation IL12B GPNMB 18402690 315295 Negative_regulation IL12B MAP2K6 18282094 3040965 Negative_regulation IL12B NEDD9 22427889 2610555 Negative_regulation IL12B NEDD9 22427889 2610556 Negative_regulation IL12B NEDD9 22427889 2610575 Negative_regulation IL12B NES 19406170 1770205 Negative_regulation IL12B STAT4 10704465 1514540 Negative_regulation IL12B STAT4 23386861 883434 Negative_regulation IL12B TLR7 16365150 1539009 Negative_regulation IL12B TLR7 18584038 3072585 Negative_regulation IL12B TLR7 18584038 3072665 Negative_regulation IL12B TLR7 18584038 3072810 Negative_regulation IL12B TLR7 18584038 3072811 Negative_regulation IL12B TLR7 19770272 1556351 Negative_regulation IL12B TLR7 20379390 1214421 Negative_regulation IL12B TLR7 23421931 590900 Negative_regulation IL12B TLR7 23787171 1666822 Negative_regulation IL12B TLR7 23967307 2836016 Negative_regulation IL12B TLR7 24489947 2917027 Negative_regulation IL12B TNF 11157054 1518373 Negative_regulation IL12B TNF 12223112 99402 Negative_regulation IL12B TNF 14568984 1529238 Negative_regulation IL12B TNF 18817542 352445 Negative_regulation IL12B TNF 19946407 34369 Negative_regulation IL12B TNF 22547990 3152601 Negative_regulation IL12B TNF 22547990 3152602 Negative_regulation IL12B TNF 22547990 3152638 Negative_regulation IL12B TNF 23049677 2698843 Negative_regulation IL12B TNF 23205044 135864 Negative_regulation IL12B TNF 24586980 2928687 Negative_regulation IL12B TNF 7722441 1591780 Negative_regulation IL12B TNFSF10 15841259 810600 Negative_regulation IL12B TP63 8551218 1595622 Negative_regulation IL12RB1 STAT4 10952721 1516614 Negative_regulation IL12RB2 STAT4 10952721 1516615 Negative_regulation IL13 ARSA 21196646 3129479 Negative_regulation IL13 ARSA 21829647 2542222 Negative_regulation IL13 EPHB2 21989417 1041862 Negative_regulation IL13 IL1B 23087507 1047614 Negative_regulation IL13 PLAT 3491174 1583129 Negative_regulation IL13 RCAN1 19124655 1553321 Negative_regulation IL13 SERPINA5 19079223 1917713 Negative_regulation IL13 TCN1 23273971 3206804 Negative_regulation IL13 TNF 20380750 291249 Negative_regulation IL13 TNF 23087507 1047613 Negative_regulation IL15 ARSA 21196646 3129480 Negative_regulation IL15 PLAT 3491174 1583130 Negative_regulation IL15 TNF 20380750 291251 Negative_regulation IL15 TNF 23208733 779605 Negative_regulation IL16 ARSA 21196646 3129481 Negative_regulation IL16 PLAT 3491174 1583131 Negative_regulation IL16 TNF 20380750 291253 Negative_regulation IL17A FOXO1 21825017 1564523 Negative_regulation IL17A FOXO1 21825017 1564524 Negative_regulation IL17A FOXO1 21825017 1564525 Negative_regulation IL17A FUT4 25180025 1761881 Negative_regulation IL17A IFI27 21326316 988601 Negative_regulation IL17A PTGER2 21946663 1041833 Negative_regulation IL17A RORC 24611151 588846 Negative_regulation IL17A TNFSF10 23497038 1666087 Negative_regulation IL17A TNFSF10 23497038 1666088 Negative_regulation IL18 ARSA 21196646 3129482 Negative_regulation IL18 FAS 24115947 909163 Negative_regulation IL18 PLAT 3491174 1583132 Negative_regulation IL18 TNF 11489953 1520487 Negative_regulation IL18 TNF 16951494 1740569 Negative_regulation IL18 TNF 20380750 291255 Negative_regulation IL18 TNF 25580276 1491714 Negative_regulation IL19 ARSA 21196646 3129483 Negative_regulation IL19 PLAT 3491174 1583133 Negative_regulation IL19 TNF 20380750 291257 Negative_regulation IL1A ADAMTS1 18387286 1731644 Negative_regulation IL1A ADAMTS1 20645923 147862 Negative_regulation IL1A ARSA 20423518 290798 Negative_regulation IL1A ARSA 22412841 2609336 Negative_regulation IL1A CAPN8 24024155 3093316 Negative_regulation IL1A CAPN8 24024155 3093345 Negative_regulation IL1A CD14 20946675 1723255 Negative_regulation IL1A CD14 20946675 1723306 Negative_regulation IL1A CD14 20946675 1723329 Negative_regulation IL1A EPHB2 22114704 2573490 Negative_regulation IL1A FAS 10704145 1737011 Negative_regulation IL1A FAS 11104808 1518130 Negative_regulation IL1A FAS 24115947 909164 Negative_regulation IL1A FAS 25114508 743186 Negative_regulation IL1A FAS 25561921 1149708 Negative_regulation IL1A FOXO1 19651810 710711 Negative_regulation IL1A FOXO1 19651810 710745 Negative_regulation IL1A FOXO1 19651810 710746 Negative_regulation IL1A FOXO1 19651810 710772 Negative_regulation IL1A HES2 20937119 845872 Negative_regulation IL1A IL1B 24665406 3179120 Negative_regulation IL1A IL1R2 21941565 3172926 Negative_regulation IL1A IL1R2 23395675 1040895 Negative_regulation IL1A IL1R2 24670367 503831 Negative_regulation IL1A ITGAL 2969406 1579441 Negative_regulation IL1A MAP2K6 24238294 356535 Negative_regulation IL1A TLR7 15809356 1535355 Negative_regulation IL1A TLR7 24011352 297898 Negative_regulation IL1A TLR7 24966466 1759779 Negative_regulation IL1A TLR7 25071732 927053 Negative_regulation IL1A TNF 12453310 99433 Negative_regulation IL1A TNF 15142264 101181 Negative_regulation IL1A TNF 15228615 101624 Negative_regulation IL1A TNF 18475483 1743991 Negative_regulation IL1A TNF 21054849 1228714 Negative_regulation IL1A TNF 21663638 2112834 Negative_regulation IL1A TNF 21810260 1697639 Negative_regulation IL1A TNF 22069489 2569238 Negative_regulation IL1A TNF 22363816 2602089 Negative_regulation IL1A TNF 22698256 1724698 Negative_regulation IL1A TNF 23217022 1024646 Negative_regulation IL1A TNF 23320032 816984 Negative_regulation IL1A TNF 23346196 817068 Negative_regulation IL1A TNF 23637542 2121223 Negative_regulation IL1A TNF 23663236 1666722 Negative_regulation IL1A TNF 23667167 1637189 Negative_regulation IL1A TNF 23940760 2832284 Negative_regulation IL1A TNF 24278618 3180349 Negative_regulation IL1A TNF 24340123 2372328 Negative_regulation IL1A TNF 24864134 1758819 Negative_regulation IL1A TNF 24914105 1684433 Negative_regulation IL1A TNF 24926352 844216 Negative_regulation IL1A TNF 24992681 2986589 Negative_regulation IL1A TNF 25067987 694749 Negative_regulation IL1A TNF 25119884 2997147 Negative_regulation IL1A TNF 25580276 1491715 Negative_regulation IL1A TNF 7530759 1589868 Negative_regulation IL1A TNFSF10 24695582 2948271 Negative_regulation IL1A TP63 25119884 2997148 Negative_regulation IL1B ADAM17 22792188 2661283 Negative_regulation IL1B AKT1 23867201 2183672 Negative_regulation IL1B AKT2 23867201 2183666 Negative_regulation IL1B AKT2 23867201 2183673 Negative_regulation IL1B ANXA1 11132768 1737192 Negative_regulation IL1B CASP1 23970884 908637 Negative_regulation IL1B CASP1 24972036 2985174 Negative_regulation IL1B CASP10 24972036 2985175 Negative_regulation IL1B CASP12 24972036 2985185 Negative_regulation IL1B CASP14 24972036 2985176 Negative_regulation IL1B CASP16 24972036 2985186 Negative_regulation IL1B CASP2 24972036 2985177 Negative_regulation IL1B CASP3 24972036 2985178 Negative_regulation IL1B CASP4 24972036 2985179 Negative_regulation IL1B CASP5 24972036 2985180 Negative_regulation IL1B CASP6 24972036 2985181 Negative_regulation IL1B CASP7 24972036 2985182 Negative_regulation IL1B CASP8 24972036 2985183 Negative_regulation IL1B CASP9 24972036 2985184 Negative_regulation IL1B CDK9 24009751 2841590 Negative_regulation IL1B CEP104 PMC3242278 1702601 Negative_regulation IL1B CEP112 PMC3242278 1702613 Negative_regulation IL1B CEP120 PMC3242278 1702611 Negative_regulation IL1B CEP128 PMC3242278 1702599 Negative_regulation IL1B CEP135 PMC3242278 1702617 Negative_regulation IL1B CEP152 PMC3242278 1702619 Negative_regulation IL1B CEP164 PMC3242278 1702618 Negative_regulation IL1B CEP170 PMC3242278 1702614 Negative_regulation IL1B CEP19 PMC3242278 1702612 Negative_regulation IL1B CEP192 PMC3242278 1702604 Negative_regulation IL1B CEP250 PMC3242278 1702598 Negative_regulation IL1B CEP290 PMC3242278 1702615 Negative_regulation IL1B CEP350 PMC3242278 1702600 Negative_regulation IL1B CEP41 PMC3242278 1702597 Negative_regulation IL1B CEP44 PMC3242278 1702620 Negative_regulation IL1B CEP55 PMC3242278 1702596 Negative_regulation IL1B CEP57 PMC3242278 1702622 Negative_regulation IL1B CEP63 PMC3242278 1702608 Negative_regulation IL1B CEP68 PMC3242278 1702616 Negative_regulation IL1B CEP70 PMC3242278 1702621 Negative_regulation IL1B CEP72 PMC3242278 1702605 Negative_regulation IL1B CEP76 PMC3242278 1702606 Negative_regulation IL1B CEP78 PMC3242278 1702607 Negative_regulation IL1B CEP85 PMC3242278 1702603 Negative_regulation IL1B CEP89 PMC3242278 1702609 Negative_regulation IL1B CEP95 PMC3242278 1702602 Negative_regulation IL1B CEP97 PMC3242278 1702610 Negative_regulation IL1B CFTR 23977375 2840135 Negative_regulation IL1B CYTL1 21799806 2538509 Negative_regulation IL1B DEFA1 23390582 3134171 Negative_regulation IL1B DEFB103A 23390582 3134170 Negative_regulation IL1B FAS 10704145 1737012 Negative_regulation IL1B GAST 21445336 2509448 Negative_regulation IL1B IL10 22768094 2659707 Negative_regulation IL1B IL13 23087507 1047618 Negative_regulation IL1B IL17D PMC3332455 134785 Negative_regulation IL1B IL1R1 19654921 793574 Negative_regulation IL1B IL1RN 21223590 332118 Negative_regulation IL1B IL1RN 22389816 1152753 Negative_regulation IL1B IL2 19664246 1722887 Negative_regulation IL1B IL4 23087507 1047619 Negative_regulation IL1B IL6 24795767 825661 Negative_regulation IL1B IL6ST 24009751 2841591 Negative_regulation IL1B JUN 23755222 2802101 Negative_regulation IL1B MAPK3 19068145 112085 Negative_regulation IL1B MYLIP 19011694 2400850 Negative_regulation IL1B MYLIP 22286305 1962095 Negative_regulation IL1B MYLIP 23516523 2768203 Negative_regulation IL1B MYLIP 23516523 2768207 Negative_regulation IL1B MYLIP 23516523 2768212 Negative_regulation IL1B MYLIP 25076967 896474 Negative_regulation IL1B NFKB1 24009751 2841592 Negative_regulation IL1B NLRP12 PMC3194427 2236096 Negative_regulation IL1B NLRP3 23915129 359288 Negative_regulation IL1B NLRP7 23970884 908638 Negative_regulation IL1B NRG1 16823072 1075296 Negative_regulation IL1B OXA1L 22286305 1962096 Negative_regulation IL1B OXA1L 25076967 896475 Negative_regulation IL1B P2RX7 18404494 3089266 Negative_regulation IL1B P2RX7 24972036 2985187 Negative_regulation IL1B PLK1 25377254 1884321 Negative_regulation IL1B PPARA 19011694 2400862 Negative_regulation IL1B PTEN 23867201 2183674 Negative_regulation IL1B RELA 24009751 2841593 Negative_regulation IL1B RIPK2 22514692 2619730 Negative_regulation IL1B TGFB2 7540612 1436808 Negative_regulation IL1B TNF 22655000 2219177 Negative_regulation IL1B TNF 23087507 1047617 Negative_regulation IL1B TNFSF4 25377254 1884320 Negative_regulation IL1B TXNIP 23915129 359289 Negative_regulation IL1R1 IL1R2 24884937 1668105 Negative_regulation IL1R2 MIR17HG 23812098 1959031 Negative_regulation IL1R2 SIGIRR 22973499 1764556 Negative_regulation IL1R2 TCL1A 22405131 471315 Negative_regulation IL1R2 TCL1A 22405131 471320 Negative_regulation IL1RL1 GATA3 25115682 686561 Negative_regulation IL1RN IL1B 22389816 1152754 Negative_regulation IL1RN TNF 19851470 175897 Negative_regulation IL2 ARSA 21196646 3129484 Negative_regulation IL2 EPHB2 16172258 1537772 Negative_regulation IL2 EPHB2 8642312 1596844 Negative_regulation IL2 FAS 23391314 1049251 Negative_regulation IL2 IL1B 19664246 1722888 Negative_regulation IL2 IL1B PMC4081846 651842 Negative_regulation IL2 ITGAL 2569026 1577442 Negative_regulation IL2 ITGAL 2952751 1579182 Negative_regulation IL2 MAP2K6 10544198 1512906 Negative_regulation IL2 MMP28 20921282 1560533 Negative_regulation IL2 MMP7 20921282 1560549 Negative_regulation IL2 MUC16 24204874 2874733 Negative_regulation IL2 PLAT 3491174 1583134 Negative_regulation IL2 TMEM100 24344781 364643 Negative_regulation IL2 TMEM156 24344781 364661 Negative_regulation IL2 TMEM211 24344781 364741 Negative_regulation IL2 TMEM213 24344781 364678 Negative_regulation IL2 TNF 17179678 1634777 Negative_regulation IL2 TNF 20041187 2435944 Negative_regulation IL2 TNF 20380750 291259 Negative_regulation IL2 TNF 21915344 2553389 Negative_regulation IL2 TNF 21915344 2553406 Negative_regulation IL2 TNF 21915344 2553415 Negative_regulation IL2 TNF 22958596 1920495 Negative_regulation IL2 TNF 25101851 2995819 Negative_regulation IL2 TNF 25157248 913823 Negative_regulation IL2 TNF 25228909 627694 Negative_regulation IL2 TNF PMC4081846 651841 Negative_regulation IL20 ARSA 21196646 3129485 Negative_regulation IL20 PLAT 3491174 1583135 Negative_regulation IL20 TNF 20380750 291261 Negative_regulation IL21 ARSA 21196646 3129486 Negative_regulation IL21 PLAT 3491174 1583136 Negative_regulation IL21 TNF 20380750 291263 Negative_regulation IL22 ARSA 21196646 3129469 Negative_regulation IL22 FOXO1 21825017 1564516 Negative_regulation IL22 FOXO1 21825017 1564517 Negative_regulation IL22 FOXO1 21825017 1564518 Negative_regulation IL22 PLAT 3491174 1583119 Negative_regulation IL22 TNF 20380750 291229 Negative_regulation IL23A TLR7 23967307 2835960 Negative_regulation IL23R FOXO1 23467085 1990280 Negative_regulation IL24 ARSA 21196646 3129466 Negative_regulation IL24 PLAT 3491174 1583117 Negative_regulation IL24 TNF 20380750 291225 Negative_regulation IL25 ARSA 21196646 3129468 Negative_regulation IL25 PLAT 3491174 1583118 Negative_regulation IL25 TNF 20380750 291227 Negative_regulation IL26 ARSA 21196646 3129473 Negative_regulation IL26 PLAT 3491174 1583123 Negative_regulation IL26 TNF 20380750 291237 Negative_regulation IL27 ARSA 21196646 3129474 Negative_regulation IL27 PLAT 3491174 1583124 Negative_regulation IL27 TNF 20380750 291239 Negative_regulation IL3 ARSA 21196646 3129487 Negative_regulation IL3 PLAT 3491174 1583137 Negative_regulation IL3 TNF 20380750 291265 Negative_regulation IL3 TNF 22963460 1698829 Negative_regulation IL3 TNF 24072209 1735776 Negative_regulation IL3 TNF 2664067 1577682 Negative_regulation IL3 TNF 7530759 1589869 Negative_regulation IL31 ARSA 21196646 3129475 Negative_regulation IL31 PLAT 3491174 1583125 Negative_regulation IL31 TNF 20380750 291241 Negative_regulation IL32 ARSA 21196646 3129472 Negative_regulation IL32 PLAT 3491174 1583122 Negative_regulation IL32 TLR7 20615213 119683 Negative_regulation IL32 TNF 20380750 291235 Negative_regulation IL32 TNF 25386048 1763147 Negative_regulation IL33 ARSA 21196646 3129471 Negative_regulation IL33 HES2 24496315 1920334 Negative_regulation IL33 HES2 24496315 1920335 Negative_regulation IL33 HES2 24496315 1920336 Negative_regulation IL33 HES2 24496315 1920360 Negative_regulation IL33 IL1RL1 22574108 2631811 Negative_regulation IL33 PLAT 3491174 1583121 Negative_regulation IL33 TNF 20380750 291233 Negative_regulation IL33 TNF 22355383 2597442 Negative_regulation IL34 ARSA 21196646 3129476 Negative_regulation IL34 FUT4 23409120 2753566 Negative_regulation IL34 PLAT 3491174 1583126 Negative_regulation IL34 TNF 20380750 291243 Negative_regulation IL37 ARSA 21196646 3129470 Negative_regulation IL37 PLAT 3491174 1583120 Negative_regulation IL37 TNF 20380750 291231 Negative_regulation IL37 TNF 24733959 1758086 Negative_regulation IL4 AGR2 2332730 1570637 Negative_regulation IL4 ARSA 21196646 3129488 Negative_regulation IL4 ARSA 21829647 2542224 Negative_regulation IL4 EPHB2 16172258 1537773 Negative_regulation IL4 EPHB2 21989417 1041840 Negative_regulation IL4 EPHB2 21989417 1041874 Negative_regulation IL4 FUT4 25180025 1761936 Negative_regulation IL4 IL1B 23087507 1047621 Negative_regulation IL4 MAP2K6 16172258 1537779 Negative_regulation IL4 MAP2K6 16172258 1537816 Negative_regulation IL4 NES 19406170 1770201 Negative_regulation IL4 PLAT 3491174 1583138 Negative_regulation IL4 STAT4 23028408 2219935 Negative_regulation IL4 TMEM100 24344781 364813 Negative_regulation IL4 TMEM156 24344781 364831 Negative_regulation IL4 TMEM211 24344781 364911 Negative_regulation IL4 TMEM213 24344781 364848 Negative_regulation IL4 TNF 15169552 3104141 Negative_regulation IL4 TNF 20380750 291267 Negative_regulation IL4 TNF 22121382 1155932 Negative_regulation IL4 TNF 22693523 636274 Negative_regulation IL4 TNF 23049677 2698844 Negative_regulation IL4 TNF 24876883 825971 Negative_regulation IL4 TNF 25228909 627696 Negative_regulation IL5 ARSA 21196646 3129489 Negative_regulation IL5 EPHB2 22783258 902365 Negative_regulation IL5 MATN2 24895400 1487891 Negative_regulation IL5 PLAT 3491174 1583139 Negative_regulation IL5 TLR7 23533311 1751807 Negative_regulation IL5 TNF 15169552 3104142 Negative_regulation IL5 TNF 20380750 291269 Negative_regulation IL5 TNF 22963460 1698830 Negative_regulation IL6 ANGPT1 23036162 660349 Negative_regulation IL6 ANO1 22973054 1807581 Negative_regulation IL6 ARSA 21196646 3129490 Negative_regulation IL6 ARSA 23306703 835024 Negative_regulation IL6 ARSA 23306703 835025 Negative_regulation IL6 ARSA 24553063 2118526 Negative_regulation IL6 CD14 20946675 1723259 Negative_regulation IL6 CD14 20946675 1723260 Negative_regulation IL6 CD14 20946675 1723307 Negative_regulation IL6 CD14 20946675 1723330 Negative_regulation IL6 CD14 22852877 532915 Negative_regulation IL6 CLU 17634137 1645582 Negative_regulation IL6 CTGF 23227240 2725710 Negative_regulation IL6 EPHB2 10544198 1512847 Negative_regulation IL6 EPHB2 11034602 1517575 Negative_regulation IL6 EPHB2 18310089 505531 Negative_regulation IL6 EPHB2 21122157 1860325 Negative_regulation IL6 EPHB2 23405061 2751544 Negative_regulation IL6 EPHB2 23405061 2751669 Negative_regulation IL6 EPHB2 24191131 1754977 Negative_regulation IL6 EPHB2 24789665 1886424 Negative_regulation IL6 F2R 21464892 2510281 Negative_regulation IL6 FAS 25561921 1149709 Negative_regulation IL6 GPR115 23049242 1225035 Negative_regulation IL6 GPR115 24911523 2977792 Negative_regulation IL6 GPR132 23049242 1225024 Negative_regulation IL6 GPR132 24911523 2977781 Negative_regulation IL6 GPR87 23049242 1225104 Negative_regulation IL6 GPR87 24911523 2977861 Negative_regulation IL6 IL1B 12745542 1738307 Negative_regulation IL6 IL6R 23995732 1929399 Negative_regulation IL6 MAP2K6 11034602 1517581 Negative_regulation IL6 MAP2K6 18282094 3040972 Negative_regulation IL6 MAP2K6 21122157 1860334 Negative_regulation IL6 MAP2K6 24238294 356546 Negative_regulation IL6 NES 19406170 1770211 Negative_regulation IL6 NT5E 23118517 1225531 Negative_regulation IL6 PGC 23050972 89637 Negative_regulation IL6 PLAT 3491174 1583140 Negative_regulation IL6 RCAN1 19124655 1553322 Negative_regulation IL6 RCAN1 19124655 1553323 Negative_regulation IL6 S100B 24084731 1113175 Negative_regulation IL6 TF 23136551 1060840 Negative_regulation IL6 TLR7 12975352 1297195 Negative_regulation IL6 TLR7 17998391 1547771 Negative_regulation IL6 TLR7 19770272 1556361 Negative_regulation IL6 TLR7 21115688 1562045 Negative_regulation IL6 TLR7 21115688 1562057 Negative_regulation IL6 TLR7 21953341 90963 Negative_regulation IL6 TLR7 25071732 927055 Negative_regulation IL6 TLR7 25101057 881019 Negative_regulation IL6 TNF 11714394 98550 Negative_regulation IL6 TNF 12745542 1738306 Negative_regulation IL6 TNF 15744804 3230716 Negative_regulation IL6 TNF 18416823 1722693 Negative_regulation IL6 TNF 18472817 1741763 Negative_regulation IL6 TNF 18475570 1744338 Negative_regulation IL6 TNF 19116667 2404027 Negative_regulation IL6 TNF 20380750 291271 Negative_regulation IL6 TNF 20461197 2114544 Negative_regulation IL6 TNF 21116333 742413 Negative_regulation IL6 TNF 21291387 668406 Negative_regulation IL6 TNF 21810260 1697641 Negative_regulation IL6 TNF 21810263 1659157 Negative_regulation IL6 TNF 22069489 2569239 Negative_regulation IL6 TNF 22121130 91006 Negative_regulation IL6 TNF 22189182 1230026 Negative_regulation IL6 TNF 22189182 1230027 Negative_regulation IL6 TNF 22190977 633837 Negative_regulation IL6 TNF 22254027 2115981 Negative_regulation IL6 TNF 22351606 778113 Negative_regulation IL6 TNF 22474527 814131 Negative_regulation IL6 TNF 22698256 1724700 Negative_regulation IL6 TNF 22956783 1637606 Negative_regulation IL6 TNF 22998440 1231249 Negative_regulation IL6 TNF 23078757 660372 Negative_regulation IL6 TNF 23087507 1047623 Negative_regulation IL6 TNF 23346196 817069 Negative_regulation IL6 TNF 23346288 1243957 Negative_regulation IL6 TNF 23383221 2749528 Negative_regulation IL6 TNF 23420671 906047 Negative_regulation IL6 TNF 23481064 1045261 Negative_regulation IL6 TNF 23505537 2766828 Negative_regulation IL6 TNF 23663236 1666725 Negative_regulation IL6 TNF 23734186 2799532 Negative_regulation IL6 TNF 23798880 2248510 Negative_regulation IL6 TNF 23805284 2808158 Negative_regulation IL6 TNF 23826152 2810560 Negative_regulation IL6 TNF 23922826 2826779 Negative_regulation IL6 TNF 24137208 843519 Negative_regulation IL6 TNF 24914105 1684435 Negative_regulation IL6 TNF 24992681 2986590 Negative_regulation IL6 TNF 8760789 1598638 Negative_regulation IL6 TNF 9788898 798138 Negative_regulation IL6ST IL6R 23995732 1929400 Negative_regulation IL6ST NR2F1 22651576 3112986 Negative_regulation IL7 ARSA 21196646 3129491 Negative_regulation IL7 FOXO1 22908014 903687 Negative_regulation IL7 PLAT 3491174 1583141 Negative_regulation IL7 TNF 20380750 291273 Negative_regulation IL8 ANO1 22973054 1807573 Negative_regulation IL8 ANO1 22973054 1807582 Negative_regulation IL8 ANO1 22973054 1807583 Negative_regulation IL8 ANO1 22973054 1807590 Negative_regulation IL8 ARSA 21196646 3129492 Negative_regulation IL8 ARSA 24039842 2844896 Negative_regulation IL8 ARSA 24039842 2844905 Negative_regulation IL8 ARSA 24553063 2118527 Negative_regulation IL8 CD14 17242961 810094 Negative_regulation IL8 CD14 17242961 810095 Negative_regulation IL8 EPHB2 21789185 2538024 Negative_regulation IL8 EPHB2 22719918 2653737 Negative_regulation IL8 EPHB2 25013817 1622412 Negative_regulation IL8 FAS 25561921 1149710 Negative_regulation IL8 FOLR1 20525114 34450 Negative_regulation IL8 IL1B 23977375 2840136 Negative_regulation IL8 ITGB2 18475729 1745904 Negative_regulation IL8 JAG1 15028114 312871 Negative_regulation IL8 MIP 7500047 1588529 Negative_regulation IL8 PLAT 3491174 1583142 Negative_regulation IL8 RCAN1 19348862 158311 Negative_regulation IL8 RCAN1 19348862 158374 Negative_regulation IL8 RCAN1 19819266 158534 Negative_regulation IL8 TLR7 20505832 2451748 Negative_regulation IL8 TNF 12110141 99247 Negative_regulation IL8 TNF 12493069 658432 Negative_regulation IL8 TNF 19014534 2232729 Negative_regulation IL8 TNF 19014534 2232762 Negative_regulation IL8 TNF 20069129 1213498 Negative_regulation IL8 TNF 20380750 291275 Negative_regulation IL8 TNF 21092318 1626186 Negative_regulation IL8 TNF 21810260 1697643 Negative_regulation IL8 TNF 22014750 211762 Negative_regulation IL8 TNF 22254027 2115982 Negative_regulation IL8 TNF 22396727 2608309 Negative_regulation IL8 TNF 22655000 2219178 Negative_regulation IL8 TNF 23441175 2756989 Negative_regulation IL8 TNF 23505537 2766829 Negative_regulation IL8 TNF 23533479 817800 Negative_regulation IL8 TNF 23533479 817801 Negative_regulation IL8 TNF 23637609 3060925 Negative_regulation IL8 TNF 23770053 1498339 Negative_regulation IL8 TNF 23967134 2834560 Negative_regulation IL8 TNF 23967134 2834610 Negative_regulation IL8 TNF 23967134 2834637 Negative_regulation IL8 TNF 24517278 131833 Negative_regulation IL8 TNF 24818101 947830 Negative_regulation IL8 TNF 24864134 1758820 Negative_regulation IL8 TNF 24914105 1684437 Negative_regulation IL8 TNF 24920275 2213768 Negative_regulation IL8 TNF 25054074 1083008 Negative_regulation IL8 TNF 25352548 2105758 Negative_regulation IL8 TNF 8760789 1598639 Negative_regulation IL9 ARSA 21196646 3129493 Negative_regulation IL9 PLAT 3491174 1583143 Negative_regulation IL9 TNF 20380750 291277 Negative_regulation INHBA NES 23662125 818803 Negative_regulation INHBA TNF 22313861 3160937 Negative_regulation INS BLVRA 22493581 951470 Negative_regulation INS CAPN8 PMC2254125 1476791 Negative_regulation INS CD14 20064776 793858 Negative_regulation INS ENPP1 21573217 2522971 Negative_regulation INS ENPP1 24770645 828859 Negative_regulation INS EPHB2 19720798 711022 Negative_regulation INS EPHB2 21998735 2562275 Negative_regulation INS EPHB2 22745639 1068553 Negative_regulation INS FAS 22095690 1033500 Negative_regulation INS FAS 22847494 1150302 Negative_regulation INS FAS 23431266 2282009 Negative_regulation INS FOXO1 19043554 2306909 Negative_regulation INS FOXO1 19371409 2112497 Negative_regulation INS FOXO1 19651810 710769 Negative_regulation INS FOXO1 20426802 1723011 Negative_regulation INS FOXO1 21335550 1190765 Negative_regulation INS FOXO1 21335550 1190766 Negative_regulation INS FOXO1 21335550 1190767 Negative_regulation INS FOXO1 21335550 1190768 Negative_regulation INS FOXO1 21483870 2512481 Negative_regulation INS FOXO1 22275878 2328865 Negative_regulation INS FOXO1 24638142 2935090 Negative_regulation INS GLP1R 21731863 1044099 Negative_regulation INS GLP1R 21868791 719752 Negative_regulation INS GLP1R 22101168 13927 Negative_regulation INS GLP1R 22101168 13935 Negative_regulation INS GLP1R 23291632 1736425 Negative_regulation INS GLP1R 24951252 3126074 Negative_regulation INS GPR115 22815809 2666097 Negative_regulation INS GPR132 22815809 2666086 Negative_regulation INS GPR87 22815809 2666166 Negative_regulation INS ID1 21940780 720679 Negative_regulation INS ID1 21940780 720680 Negative_regulation INS ID1 21940780 720686 Negative_regulation INS ID1 21940780 720687 Negative_regulation INS ID1 21940780 720691 Negative_regulation INS ID1 21940780 720693 Negative_regulation INS IGFBP1 23983688 1073754 Negative_regulation INS IGFBP1 24386010 745869 Negative_regulation INS IL1B 7520478 1589488 Negative_regulation INS JAG1 21124801 2484128 Negative_regulation INS KRT38 23565276 2777725 Negative_regulation INS MMP28 20828387 508164 Negative_regulation INS MMP7 20828387 508179 Negative_regulation INS PGC 24843456 1493267 Negative_regulation INS PLAGL1 23560115 2776966 Negative_regulation INS STAT4 23939393 728372 Negative_regulation INS TGM2 1356992 1297644 Negative_regulation INS TLR7 24758278 1726863 Negative_regulation INS TNF 16864906 1740337 Negative_regulation INS TNF 17958881 507727 Negative_regulation INS TNF 19188427 707821 Negative_regulation INS TNF 19558671 1722867 Negative_regulation INS TNF 19597296 736296 Negative_regulation INS TNF 20007934 712158 Negative_regulation INS TNF 22276152 2590194 Negative_regulation INS TNF 22500980 355774 Negative_regulation INS TNF 22523688 1683310 Negative_regulation INS TNF 22550485 1072970 Negative_regulation INS TNF 22691241 126141 Negative_regulation INS TNF 22691241 126146 Negative_regulation INS TNF 22701472 833147 Negative_regulation INS TNF 22829955 2224565 Negative_regulation INS TNF 22942720 1097106 Negative_regulation INS TNF 23155382 2716989 Negative_regulation INS TNF 23300290 730000 Negative_regulation INS TNF 23590862 2113889 Negative_regulation INS TNF 23592916 1915848 Negative_regulation INS TNF 23671428 95354 Negative_regulation INS TNF 24101950 2227226 Negative_regulation INS TNF 24563869 1495678 Negative_regulation INS TNF 25258478 1762461 Negative_regulation INS TNF 25352752 1917434 Negative_regulation INS TNF 25352752 1917486 Negative_regulation INS TNF 25352752 1917498 Negative_regulation INS TNF 7530759 1589778 Negative_regulation INS TNF 7530759 1589871 Negative_regulation INS TNF 7530759 1589916 Negative_regulation INS TNF 7530759 1589917 Negative_regulation INS TNF 7530759 1589918 Negative_regulation INS TNF 7530759 1589923 Negative_regulation INS TNF 7530759 1589939 Negative_regulation INS TNF 9716913 702601 Negative_regulation INSR ENPP1 17849011 2378078 Negative_regulation INSR ENPP1 22043164 678342 Negative_regulation INSR ENPP1 23894607 2825428 Negative_regulation INSR IGFBP1 24194988 515035 Negative_regulation INSR IL1B 24618842 2933379 Negative_regulation INSR TNF 21960997 979955 Negative_regulation INSR TNF 25191587 1670075 Negative_regulation IPO11 MAP2K6 20041180 2435757 Negative_regulation IPO11 MAP2K6 20041180 2435831 Negative_regulation IPO13 MAP2K6 20041180 2435730 Negative_regulation IPO13 MAP2K6 20041180 2435807 Negative_regulation IPO4 MAP2K6 20041180 2435748 Negative_regulation IPO4 MAP2K6 20041180 2435823 Negative_regulation IPO5 MAP2K6 20041180 2435766 Negative_regulation IPO5 MAP2K6 20041180 2435839 Negative_regulation IPO7 MAP2K6 20041180 2435789 Negative_regulation IPO7 MAP2K6 20041180 2435847 Negative_regulation IPO8 MAP2K6 20041180 2435798 Negative_regulation IPO8 MAP2K6 20041180 2435855 Negative_regulation IPO9 MAP2K6 20041180 2435739 Negative_regulation IPO9 MAP2K6 20041180 2435815 Negative_regulation IRAK3 TLR7 21390243 1049792 Negative_regulation IRAK3 TLR7 22928050 2681783 Negative_regulation IRAK3 TLR7 22928050 2681922 Negative_regulation IRAK4 TNF 7931065 1593188 Negative_regulation IRF1 TNF 20615213 119675 Negative_regulation IRF6 TP63 24940735 2980714 Negative_regulation IRF6 TP63 24940735 2980722 Negative_regulation IRS1 EPHB2 19953085 1903254 Negative_regulation IRS1 FOXO1 PMC3357269 728866 Negative_regulation IRS1 GLP1R 24843644 1494478 Negative_regulation IRS1 IRS4 25003579 2195072 Negative_regulation IRS1 MAP2K6 21408212 2292325 Negative_regulation IRS1 TNF 19808894 711169 Negative_regulation IRS1 TNF 20184722 2112597 Negative_regulation IRS1 TNF 21558756 3079186 Negative_regulation IRS1 TNF 21960997 979956 Negative_regulation IRS1 TNF 22207907 1238543 Negative_regulation IRS1 TNF 22246875 1920543 Negative_regulation IRS1 TNF 22691241 126147 Negative_regulation IRS1 TNF 23022959 613803 Negative_regulation IRS1 TNF 23193206 729967 Negative_regulation IRS1 TNF 24101950 2227247 Negative_regulation IRS1 TNF 24481061 1123549 Negative_regulation IRS1 TNF 25352752 1917436 Negative_regulation IRS2 FOXO1 22477519 1239002 Negative_regulation IRS2 IRS4 25003579 2195073 Negative_regulation IRS2 TNF 22207907 1238544 Negative_regulation IRS2 TNF 23193206 729969 Negative_regulation IRS2 TNF 24101950 2227261 Negative_regulation IRS4 ANGPT2 21829546 2541674 Negative_regulation IRS4 ASB4 21955513 387321 Negative_regulation IRS4 IGF1 19534786 525654 Negative_regulation ISL1 MAP2K6 19077309 1994063 Negative_regulation ITCH EPHB2 24708812 1843038 Negative_regulation ITCH EPHB2 24708812 1843047 Negative_regulation ITCH EPHB2 24708812 1843050 Negative_regulation ITGAL ACD 20733035 1559670 Negative_regulation ITGAL APOE 18560564 2391327 Negative_regulation ITGAL CD53 24832104 2970520 Negative_regulation ITGAL CD81 12597781 350424 Negative_regulation ITGAL EDIL3 20157603 1037597 Negative_regulation ITGAL EDIL3 24416060 639489 Negative_regulation ITGAL EDN1 18029384 90722 Negative_regulation ITGAL ENPEP 16585266 1539889 Negative_regulation ITGAL GZMB 23935498 3063397 Negative_regulation ITGAL ICAM1 24945611 2981358 Negative_regulation ITGAL ICAM3 7518468 1435570 Negative_regulation ITGAL KIR3DL1 18818767 2396858 Negative_regulation ITGAL MRE11A 20733035 1559673 Negative_regulation ITGAL PARP1 20733035 1559671 Negative_regulation ITGAL POT1 20733035 1559668 Negative_regulation ITGAL PTX3 12566419 1525899 Negative_regulation ITGAL PTX4 12566419 1525898 Negative_regulation ITGAL RAD50 20733035 1559674 Negative_regulation ITGAL STK4 24040101 2845674 Negative_regulation ITGAL TERF1 20733035 1559664 Negative_regulation ITGAL TERF2 20733035 1559665 Negative_regulation ITGAL TERF2IP 20733035 1559669 Negative_regulation ITGAL TINF2 20733035 1559666 Negative_regulation ITGAL VCAM1 10224287 1511714 Negative_regulation ITGAL XRCC5 20733035 1559667 Negative_regulation ITGAL XRCC6 20733035 1559672 Negative_regulation ITGAM EPHB2 23549262 1104686 Negative_regulation ITGAM SELL 23667167 1637169 Negative_regulation ITGB1 ITGB2 19223596 708074 Negative_regulation ITGB2 ADIPOQ 23935932 2828501 Negative_regulation ITGB2 AKAP13 19277197 2407736 Negative_regulation ITGB2 AKAP13 19277197 2407764 Negative_regulation ITGB2 APOE 18560564 2391329 Negative_regulation ITGB2 CA2 1346139 1297619 Negative_regulation ITGB2 CBR1 1676048 1540590 Negative_regulation ITGB2 CCR7 10620605 1513829 Negative_regulation ITGB2 CCR7 24195963 988970 Negative_regulation ITGB2 ESAM 11097205 702043 Negative_regulation ITGB2 FGB 7744962 1440106 Negative_regulation ITGB2 GPI PMC2778879 391039 Negative_regulation ITGB2 GZMB 23935498 3063383 Negative_regulation ITGB2 H1F0 23935498 3063384 Negative_regulation ITGB2 ICAM1 17078873 3116397 Negative_regulation ITGB2 ICAM1 23097741 1728573 Negative_regulation ITGB2 IL4 16001979 3105084 Negative_regulation ITGB2 JAK2 24368807 1413101 Negative_regulation ITGB2 JAK3 24368807 1413102 Negative_regulation ITGB2 KIR3DL1 16203869 1538026 Negative_regulation ITGB2 MOK 21347371 2503706 Negative_regulation ITGB2 MYL2 25133611 2998719 Negative_regulation ITGB2 NUP153 18475516 1744147 Negative_regulation ITGB2 NUP153 18475516 1744148 Negative_regulation ITGB2 NUP153 18475516 1744156 Negative_regulation ITGB2 NUP153 18475518 1744176 Negative_regulation ITGB2 NUP153 18475518 1744177 Negative_regulation ITGB2 NUP153 18475518 1744185 Negative_regulation ITGB2 NUP210 18475516 1744145 Negative_regulation ITGB2 NUP210 18475516 1744146 Negative_regulation ITGB2 NUP210 18475516 1744155 Negative_regulation ITGB2 NUP210 18475518 1744174 Negative_regulation ITGB2 NUP210 18475518 1744175 Negative_regulation ITGB2 NUP210 18475518 1744184 Negative_regulation ITGB2 NUP214 18475516 1744149 Negative_regulation ITGB2 NUP214 18475516 1744150 Negative_regulation ITGB2 NUP214 18475516 1744157 Negative_regulation ITGB2 NUP214 18475518 1744178 Negative_regulation ITGB2 NUP214 18475518 1744179 Negative_regulation ITGB2 NUP214 18475518 1744186 Negative_regulation ITGB2 NUP62 18475516 1744151 Negative_regulation ITGB2 NUP62 18475516 1744152 Negative_regulation ITGB2 NUP62 18475516 1744158 Negative_regulation ITGB2 NUP62 18475518 1744180 Negative_regulation ITGB2 NUP62 18475518 1744181 Negative_regulation ITGB2 NUP62 18475518 1744187 Negative_regulation ITGB2 RANBP2 18475516 1744153 Negative_regulation ITGB2 RANBP2 18475516 1744154 Negative_regulation ITGB2 RANBP2 18475516 1744159 Negative_regulation ITGB2 RANBP2 18475518 1744182 Negative_regulation ITGB2 RANBP2 18475518 1744183 Negative_regulation ITGB2 RANBP2 18475518 1744188 Negative_regulation ITGB2 RHOH 18823547 524911 Negative_regulation ITGB2 STK4 25133611 2998718 Negative_regulation ITGB2 TFPI 23508943 906586 Negative_regulation ITIH4 TNF 25078297 1900292 Negative_regulation IVD MMP28 21801383 1652100 Negative_regulation IVL LAMB3 8647901 1451710 Negative_regulation JAG1 AGXT 21479216 2511185 Negative_regulation JAG1 ANGPT1 22558265 2624886 Negative_regulation JAG1 ANGPT1 22558265 2624911 Negative_regulation JAG1 ATP5O 15028114 312874 Negative_regulation JAG1 BACE1 25591666 3149655 Negative_regulation JAG1 BHLHE41 24997474 274243 Negative_regulation JAG1 CD46 23086448 1958063 Negative_regulation JAG1 CD46 23086448 1958106 Negative_regulation JAG1 DLL1 18665263 2394134 Negative_regulation JAG1 DLL1 19161597 302038 Negative_regulation JAG1 DLL1 22390640 124851 Negative_regulation JAG1 DLL1 22390640 124852 Negative_regulation JAG1 DLL4 25309874 948781 Negative_regulation JAG1 ERF 23630463 866826 Negative_regulation JAG1 HNRNPF 20479116 1558232 Negative_regulation JAG1 HNRNPH1 20479116 1558233 Negative_regulation JAG1 IL10 11304549 1519260 Negative_regulation JAG1 IL8 15028114 312873 Negative_regulation JAG1 LFNG 19161597 302039 Negative_regulation JAG1 LFNG 25255098 761887 Negative_regulation JAG1 MYLIP 21887253 2548196 Negative_regulation JAG1 MYLIP 21887253 2548873 Negative_regulation JAG1 MYLIP 22629283 882496 Negative_regulation JAG1 MYLIP 24659709 2188440 Negative_regulation JAG1 MYLIP 24659709 2188441 Negative_regulation JAG1 MYLIP 24659709 2188443 Negative_regulation JAG1 MYLIP 24659709 2188444 Negative_regulation JAG1 MYLIP 24659709 2188445 Negative_regulation JAG1 MYLIP 24694752 3141357 Negative_regulation JAG1 MYLIP 24694752 3141393 Negative_regulation JAG1 NOTCH1 25309874 948782 Negative_regulation JAG1 NOTCH2 25309874 948783 Negative_regulation JAG1 NOTCH3 25309874 948784 Negative_regulation JAG1 NOTCH4 25309874 948785 Negative_regulation JAG1 NPAT 16410827 2302155 Negative_regulation JAG1 OSR1 24931004 1681255 Negative_regulation JAG1 OSR1 24931004 1681278 Negative_regulation JAG1 PRDX2 24157878 568586 Negative_regulation JAG1 PRDX2 24456602 1482891 Negative_regulation JAG1 PTBP1 20479116 1558234 Negative_regulation JAG1 PTBP2 20479116 1558231 Negative_regulation JAG1 SOD1 20522599 714068 Negative_regulation JAG1 SOD1 20522599 714074 Negative_regulation JAG1 SOD1 25609923 744619 Negative_regulation JAG1 SOD2 20522599 714069 Negative_regulation JAG1 SOD2 20522599 714075 Negative_regulation JAG1 SOD3 20522599 714070 Negative_regulation JAG1 SOD3 20522599 714076 Negative_regulation JAG1 TLR3 20436665 2448785 Negative_regulation JAG1 TLR3 25025040 194656 Negative_regulation JAG1 TLR4 25025040 194657 Negative_regulation JAG1 UVRAG 23863842 2091419 Negative_regulation JAK1 EPHB2 22567028 634408 Negative_regulation JAK1 MAP2K6 20929579 1859762 Negative_regulation JAK1 MAP2K6 23300886 2737146 Negative_regulation JAK1 TLR7 23505488 2766212 Negative_regulation JAK1 TNF 22351606 778114 Negative_regulation JAK2 EPHB2 22567028 634409 Negative_regulation JAK2 MAP2K6 20929579 1859769 Negative_regulation JAK2 MAP2K6 23300886 2737153 Negative_regulation JAK2 TLR7 23505488 2766223 Negative_regulation JAK2 TNF 22351606 778115 Negative_regulation JAK3 EPHB2 22567028 634410 Negative_regulation JAK3 MAP2K6 20929579 1859776 Negative_regulation JAK3 MAP2K6 23300886 2737160 Negative_regulation JAK3 TLR7 23505488 2766234 Negative_regulation JAK3 TNF 22351606 778116 Negative_regulation JUN EPHB2 15123736 1308402 Negative_regulation JUN EPHB2 19432991 1850744 Negative_regulation JUN EPHB2 19961337 1237252 Negative_regulation JUN EPHB2 22125256 217457 Negative_regulation JUN EPHB2 22384111 2604162 Negative_regulation JUN EPHB2 23243430 816469 Negative_regulation JUN EPHB2 23843873 821190 Negative_regulation JUN EPHB2 23946780 2165336 Negative_regulation JUN EPHB2 23967228 2835120 Negative_regulation JUN EPHB2 24671046 3141191 Negative_regulation JUN EPHB2 25121739 2997352 Negative_regulation JUN EPHB2 25203554 3006420 Negative_regulation JUN EPHB2 8642312 1596845 Negative_regulation JUN FOXO1 23675967 536244 Negative_regulation JUN IL1B 22642771 1662987 Negative_regulation JUN MAP2K6 22125256 217463 Negative_regulation JUN TNF 20406462 1853945 Negative_regulation JUN TNF 20418897 9902 Negative_regulation JUN TNF 21152033 2485836 Negative_regulation JUN TNF 21915344 2553390 Negative_regulation JUN TNF 21915344 2553417 Negative_regulation JUN TNF 21915344 2553445 Negative_regulation JUN TNF 22199113 1045049 Negative_regulation JUN TNF 22690271 2224392 Negative_regulation JUN TNF 23784308 606107 Negative_regulation JUN TNF 23803414 3121927 Negative_regulation KARS GRIK2 22522402 1967680 Negative_regulation KAT2B CCND1 23880895 606214 Negative_regulation KAT8 HES2 23849347 660485 Negative_regulation KCNH4 EPHB2 24945272 2372803 Negative_regulation KCNK3 IYD 24586202 2357086 Negative_regulation KCNK3 KCNK2 15940829 2001660 Negative_regulation KCNK3 ST8SIA2 24743596 1823350 Negative_regulation KCNK6 KCNK2 15940829 2001663 Negative_regulation KDELR1 EPHB2 23325787 1810982 Negative_regulation KDELR2 EPHB2 23325787 1810984 Negative_regulation KDELR3 EPHB2 23325787 1810986 Negative_regulation KDR ANGPT1 23575676 1935912 Negative_regulation KDR ANGPT1 25371820 1690101 Negative_regulation KDR EPHB2 22941289 15978 Negative_regulation KDR RCAN1 20625401 2454984 Negative_regulation KHSRP EPHB2 22998978 1724988 Negative_regulation KL EPHB2 24386260 2903392 Negative_regulation KL TNF 21593200 719220 Negative_regulation KL TNF 22567283 1139556 Negative_regulation KLF15 TNF 24358263 2899147 Negative_regulation KLF2 EDN2 25599087 33752 Negative_regulation KLF2 FOXO1 21825017 1564593 Negative_regulation KLF2 KLF9 18406357 158149 Negative_regulation KLF4 ZFP57 24412312 615953 Negative_regulation KLF5 EGLN3 22905089 2675265 Negative_regulation KLF7 FOXO1 22399922 3158680 Negative_regulation KLF9 EDN1 18406357 158125 Negative_regulation KLF9 KLF2 18406357 158126 Negative_regulation KLF9 MYLIP 24349493 2898333 Negative_regulation KLF9 MYLIP 24397367 510524 Negative_regulation KLK5 TNF 24534191 1575080 Negative_regulation KLKB1 FOXA1 24875621 1942337 Negative_regulation KLKB1 TFPI2 18053161 370957 Negative_regulation KMT2A HES2 23849347 660499 Negative_regulation KMT2D HES2 23849347 660506 Negative_regulation KPNA3 EPHB2 21087211 148177 Negative_regulation KPNA3 EPHB2 21087211 148196 Negative_regulation KRAS CCND1 18834508 583302 Negative_regulation KRAS EPHB2 19492026 3398 Negative_regulation KRAS EPHB2 19953086 1903258 Negative_regulation KRAS EPHB2 22701199 2234548 Negative_regulation KRAS EPHB2 24071646 566579 Negative_regulation KRAS EPHB2 25003010 3092914 Negative_regulation KRAS EPHB2 25275294 2202397 Negative_regulation KRAS IFI27 14680481 458014 Negative_regulation KRAS LGALS7B 23530091 2182796 Negative_regulation KRAS LGALS7B 23530091 2182797 Negative_regulation KRAS LGALS7B 23530091 2182798 Negative_regulation KRAS LGALS7B 23530091 2182799 Negative_regulation KRAS LGALS7B 23530091 2182830 Negative_regulation KRAS LGALS7B 23530091 2182865 Negative_regulation KRAS LGALS7B 23530091 2182866 Negative_regulation KRAS LGALS7B 23530091 2182896 Negative_regulation KRAS LGALS7B 23530091 2182904 Negative_regulation KRAS LGALS7B 23530091 2182916 Negative_regulation KRAS MAP2K6 21151481 2485020 Negative_regulation KRAS MAP2K6 24392017 2905193 Negative_regulation KRAS MAP2K6 24970815 2194255 Negative_regulation KREMEN1 FZD4 21668411 149330 Negative_regulation KRR1 EPHB2 25352744 1917357 Negative_regulation KRT18 NES 23145110 2715779 Negative_regulation KRT38 EGF 2447102 1415696 Negative_regulation KRT38 EGFR 17178906 1335665 Negative_regulation KRT38 GPRC5D 21244661 1007680 Negative_regulation KRT38 KRT1 17668073 2377507 Negative_regulation KRT38 KRT10 17668073 2377508 Negative_regulation KRT38 KRT18 1697294 1333396 Negative_regulation KRT38 SLC22A3 23536778 2771659 Negative_regulation KRT38 VIM 23690850 819136 Negative_regulation KRT38 WNT1 23918954 1573230 Negative_regulation KRT38 WNT11 23918954 1573231 Negative_regulation KRT38 WNT16 23918954 1573236 Negative_regulation KRT38 WNT2 23918954 1573232 Negative_regulation KRT38 WNT3 23918954 1573233 Negative_regulation KRT38 WNT4 23918954 1573234 Negative_regulation KRT38 WNT6 23918954 1573235 Negative_regulation KRT5 EPHB2 23708665 2152379 Negative_regulation KRT8 WIF1 20573255 1856517 Negative_regulation KRTAP9-9 NES 9151683 1460088 Negative_regulation L1CAM IFI27 16780593 579973 Negative_regulation LAD1 ITGB2 22474478 634214 Negative_regulation LAD1 ITGB2 25165726 1623132 Negative_regulation LAMB3 ZIC1 21347233 2503397 Negative_regulation LANCL1 EPHB2 22537317 355836 Negative_regulation LANCL1 TLR7 18584038 3072675 Negative_regulation LAT FAS 19487421 1555089 Negative_regulation LBH CCND1 25557837 3149185 Negative_regulation LBP CAMP 23840194 908069 Negative_regulation LBP FGFR3 24219868 221095 Negative_regulation LBP HMGB1 21660935 808367 Negative_regulation LBP MYLIP 24741638 1621438 Negative_regulation LBP MYLIP 24741638 1621442 Negative_regulation LBP NOS2 23517687 294300 Negative_regulation LCK EPHB2 12810687 1527633 Negative_regulation LCK EPHB2 23071622 2703416 Negative_regulation LCK EPHB2 23874979 2823937 Negative_regulation LCT TFPI2 23703216 2088607 Negative_regulation LCT TNF 24490170 186729 Negative_regulation LDHD MAP2K6 22970192 2687688 Negative_regulation LDLR PCSK9 17328821 279520 Negative_regulation LDLR PCSK9 17971861 2380084 Negative_regulation LDLR PCSK9 19196236 146449 Negative_regulation LDLR PCSK9 19196236 146450 Negative_regulation LDLR PCSK9 21352602 1723469 Negative_regulation LDLR PCSK9 21513517 2112795 Negative_regulation LDLR PCSK9 21792295 742466 Negative_regulation LDLR PCSK9 21991404 1638798 Negative_regulation LDLR PCSK9 22461740 3229284 Negative_regulation LDLR PCSK9 22701100 657962 Negative_regulation LDLR PCSK9 22848640 2669912 Negative_regulation LDLR PCSK9 22848640 2669913 Negative_regulation LDLR PCSK9 22962999 1724920 Negative_regulation LDLR PCSK9 23135270 1205605 Negative_regulation LDLR PCSK9 23135270 1205606 Negative_regulation LDLR PCSK9 23135270 1205607 Negative_regulation LDLR PCSK9 23135270 1205610 Negative_regulation LDLR PCSK9 23997648 679587 Negative_regulation LDLR PCSK9 24115837 742803 Negative_regulation LDLR PCSK9 24115837 742815 Negative_regulation LDLR PCSK9 24252756 179019 Negative_regulation LDLR PCSK9 24252756 179026 Negative_regulation LDLR PCSK9 25042549 19265 Negative_regulation LDLR PCSK9 25042549 19285 Negative_regulation LEF1 OSR1 24931004 1681315 Negative_regulation LEF1 WIF1 20573255 1856518 Negative_regulation LEF1 WIF1 20573255 1856556 Negative_regulation LEFTY1 CCND1 25473455 1144967 Negative_regulation LEFTY2 CCND1 25473455 1144963 Negative_regulation LEO1 F2R PMC2756345 495996 Negative_regulation LEO1 LPCAT1 25415055 177542 Negative_regulation LEO1 TNF 18472926 1743192 Negative_regulation LEO1 TNF 3119758 1580177 Negative_regulation LEP CD14 24192824 1121490 Negative_regulation LEP EPHB2 23216800 2113711 Negative_regulation LEP EPHB2 23634146 2119888 Negative_regulation LEP MMP28 24202338 497530 Negative_regulation LEP MMP7 24202338 497545 Negative_regulation LEP TNF 19875582 729355 Negative_regulation LEP TNF 22373492 3179396 Negative_regulation LEP TNF 23343052 1036487 Negative_regulation LEP TNF 23383125 2748053 Negative_regulation LEP TNF 23565495 1044589 Negative_regulation LEPR CCND1 17274833 460657 Negative_regulation LGALS1 LGALS7B 23530091 2182801 Negative_regulation LGALS3 IFI27 24971481 549037 Negative_regulation LGALS7B AKTIP 23530091 2182847 Negative_regulation LGALS7B BCL2 21289092 1786214 Negative_regulation LGALS7B ELL 20053728 2051537 Negative_regulation LGALS7B HRAS 23530091 2182774 Negative_regulation LGALS7B HRAS 23530091 2182775 Negative_regulation LGALS7B HRAS 23530091 2182776 Negative_regulation LGALS7B HRAS 23530091 2182777 Negative_regulation LGALS7B HRAS 23530091 2182778 Negative_regulation LGALS7B HRAS 23530091 2182779 Negative_regulation LGALS7B HRAS 23530091 2182826 Negative_regulation LGALS7B HRAS 23530091 2182848 Negative_regulation LGALS7B HRAS 23530091 2182849 Negative_regulation LGALS7B HRAS 23530091 2182850 Negative_regulation LGALS7B HRAS 23530091 2182851 Negative_regulation LGALS7B HRAS 23530091 2182885 Negative_regulation LGALS7B HRAS 23530091 2182886 Negative_regulation LGALS7B KRAS 23530091 2182780 Negative_regulation LGALS7B KRAS 23530091 2182781 Negative_regulation LGALS7B KRAS 23530091 2182782 Negative_regulation LGALS7B KRAS 23530091 2182783 Negative_regulation LGALS7B KRAS 23530091 2182784 Negative_regulation LGALS7B KRAS 23530091 2182827 Negative_regulation LGALS7B KRAS 23530091 2182852 Negative_regulation LGALS7B KRAS 23530091 2182853 Negative_regulation LGALS7B KRAS 23530091 2182854 Negative_regulation LGALS7B KRAS 23530091 2182855 Negative_regulation LGALS7B KRAS 23530091 2182887 Negative_regulation LGALS7B KRAS 23530091 2182888 Negative_regulation LGALS7B LGALS1 23530091 2182785 Negative_regulation LGALS7B NRAS 23530091 2182786 Negative_regulation LGALS7B NRAS 23530091 2182787 Negative_regulation LGALS7B NRAS 23530091 2182788 Negative_regulation LGALS7B NRAS 23530091 2182789 Negative_regulation LGALS7B NRAS 23530091 2182790 Negative_regulation LGALS7B NRAS 23530091 2182828 Negative_regulation LGALS7B NRAS 23530091 2182856 Negative_regulation LGALS7B NRAS 23530091 2182857 Negative_regulation LGALS7B NRAS 23530091 2182858 Negative_regulation LGALS7B NRAS 23530091 2182859 Negative_regulation LGALS7B NRAS 23530091 2182889 Negative_regulation LGALS7B NRAS 23530091 2182890 Negative_regulation LGALS7B TCEA1 20053728 2051536 Negative_regulation LGALS7B TP53 23530091 2182825 Negative_regulation LGMN CST6 20074384 255197 Negative_regulation LGMN CST6 20074384 255200 Negative_regulation LGMN CST6 20074384 255201 Negative_regulation LGMN CST6 20074384 255204 Negative_regulation LGMN CST6 24742492 2188905 Negative_regulation LGMN CST6 24742492 2188906 Negative_regulation LGMN CST6 24742492 2188908 Negative_regulation LGMN CST6 24742492 2188913 Negative_regulation LHB FOXO1 23284914 2731280 Negative_regulation LHB FOXO1 25423188 3030042 Negative_regulation LHCGR PLAT 23565150 2777024 Negative_regulation LHX2 PLAU 23864708 1816982 Negative_regulation LHX2 PLAU 23864708 1816985 Negative_regulation LHX6 LHX4 25120431 869980 Negative_regulation LIF MAP2K6 24721906 2358146 Negative_regulation LIF MAP2K6 24957798 3142744 Negative_regulation LIN37 TNF 1375270 1528769 Negative_regulation LIN52 TNF 1375270 1528766 Negative_regulation LIN54 TNF 1375270 1528767 Negative_regulation LIN9 TNF 1375270 1528768 Negative_regulation LINC00284 LMNA 22574215 2632610 Negative_regulation LINC00341 LMNA 22574215 2632570 Negative_regulation LIPA FOXO1 24136225 568091 Negative_regulation LIPE TNF 24098322 2855794 Negative_regulation LIPG APOC1 25005712 297544 Negative_regulation LIPG MSTN 20161803 2440917 Negative_regulation LIPG NOS2 24415940 3065960 Negative_regulation LIPG NRIP1 22389706 2607990 Negative_regulation LIPG RAC1 23423567 726391 Negative_regulation LIPG TNF 16177180 2017703 Negative_regulation LMNA TNF 21738489 2325067 Negative_regulation LMO4 MAP2K6 19648968 2126241 Negative_regulation LMX1A MSX1 18826576 1832825 Negative_regulation LMX1A MSX1 23789101 169760 Negative_regulation LOR FLG 25010647 2988001 Negative_regulation LOX ALOX5 23181808 482646 Negative_regulation LOX EGLN3 25161887 1888483 Negative_regulation LOX EPHB2 23750284 2801488 Negative_regulation LOX TNF 23785354 878843 Negative_regulation LOX TNF 24971753 2985023 Negative_regulation LOX TNF 24971753 2985037 Negative_regulation LOX TNF 24971753 2985041 Negative_regulation LOX TNF 24971753 2985053 Negative_regulation LOX TNF 24971753 2985054 Negative_regulation LOX TNF 24971753 2985087 Negative_regulation LOX TNF 24971753 2985092 Negative_regulation LOX TNF 25229347 3007965 Negative_regulation LOX TNF 25229347 3007967 Negative_regulation LPA ANGPT1 19297368 513369 Negative_regulation LPA ANGPT1 19297368 513372 Negative_regulation LPA MMP28 23688423 314140 Negative_regulation LPA MMP7 23688423 314155 Negative_regulation LPA PLAT 21046291 665335 Negative_regulation LPCAT1 CDC73 23949154 441532 Negative_regulation LPCAT1 CTR9 23949154 441533 Negative_regulation LPCAT1 LEO1 23949154 441536 Negative_regulation LPCAT1 MPZ 23949154 441524 Negative_regulation LPCAT1 PAF1 23949154 441534 Negative_regulation LPCAT1 WDR61 23949154 441535 Negative_regulation LPL FAS 23056264 2700749 Negative_regulation LPL FAS 23056264 2700768 Negative_regulation LPL MIP 3279154 1580740 Negative_regulation LPL TNF 16106106 1740060 Negative_regulation LPL TNF 19925655 327032 Negative_regulation LPL TNF 22523688 1683312 Negative_regulation LPL TNF 22682420 126123 Negative_regulation LPL TNF 23526980 2769117 Negative_regulation LPL TNF 24733068 1126077 Negative_regulation LPL TNF 24790463 629888 Negative_regulation LPL TNF 3358907 443326 Negative_regulation LPL TNF 3390373 443338 Negative_regulation LPL TNF 3756079 443542 Negative_regulation LPL TNF 3760780 1583651 Negative_regulation LPO MMP28 25505905 23382 Negative_regulation LPO MMP7 25505905 23399 Negative_regulation LPP SNCAIP 21490799 1638249 Negative_regulation LRP1 PCSK9 20427281 1187565 Negative_regulation LRP1 PCSK9 23675525 2793516 Negative_regulation LRP1 PCSK9 25340851 3018944 Negative_regulation LRP1 TNFSF10 25276252 3085787 Negative_regulation LRP10 TNFSF10 25276252 3085784 Negative_regulation LRP11 TNFSF10 25276252 3085785 Negative_regulation LRP12 TNFSF10 25276252 3085786 Negative_regulation LRP2 TNFSF10 25276252 3085788 Negative_regulation LRP3 TNFSF10 25276252 3085789 Negative_regulation LRP4 TNFSF10 25276252 3085790 Negative_regulation LRP5 TNFSF10 25276252 3085791 Negative_regulation LRP6 OSR1 24931004 1681316 Negative_regulation LRP6 TNFSF10 25276252 3085792 Negative_regulation LRP8 PCSK9 24252756 179024 Negative_regulation LRP8 TNFSF10 25276252 3085793 Negative_regulation LRRK2 EPHB2 22666358 2647875 Negative_regulation LRRK2 RGS2 25071441 932191 Negative_regulation LRRN2 HOXB1 19602272 1994796 Negative_regulation LRRN2 SHH 19602272 1994795 Negative_regulation LSR ITGB2 14557414 1529183 Negative_regulation LTB ALOX5 25045574 1083002 Negative_regulation LTB MAP2K6 24634497 1624465 Negative_regulation LTB TLR7 24634497 1624513 Negative_regulation LTB TNF 1732411 1544491 Negative_regulation LTB4R ALOX5 24634497 1624469 Negative_regulation LY96 CD14 14517279 1529118 Negative_regulation LY96 MAP2K6 21909400 2551981 Negative_regulation MADCAM1 TNF 12625840 312746 Negative_regulation MADCAM1 TNF 16259632 1624793 Negative_regulation MAFB FOXO1 22399922 3158681 Negative_regulation MALT1 EPHB2 21048967 2480263 Negative_regulation MALT1 EPHB2 22396737 2608349 Negative_regulation MALT1 TNF 22396737 2608348 Negative_regulation MAML3 DVL2 23132247 703219 Negative_regulation MAML3 NOTCH1 17998388 1547704 Negative_regulation MAML3 NOTCH2 17998388 1547705 Negative_regulation MAML3 NOTCH3 17998388 1547706 Negative_regulation MAML3 NOTCH4 17998388 1547707 Negative_regulation MAOA DBH 24116298 204433 Negative_regulation MAOA GGA1 23170116 842662 Negative_regulation MAOA GGA1 23170116 842663 Negative_regulation MAOA GGA1 23170116 842672 Negative_regulation MAOA GGA1 23170116 842678 Negative_regulation MAOA GGA2 23170116 842658 Negative_regulation MAOA GGA2 23170116 842659 Negative_regulation MAOA GGA2 23170116 842670 Negative_regulation MAOA GGA2 23170116 842676 Negative_regulation MAOA GGA3 23170116 842660 Negative_regulation MAOA GGA3 23170116 842661 Negative_regulation MAOA GGA3 23170116 842671 Negative_regulation MAOA GGA3 23170116 842677 Negative_regulation MAOA IL6 22906985 1718402 Negative_regulation MAOA IL6 22906985 1718410 Negative_regulation MAOA IL6 22906985 1718411 Negative_regulation MAOA IL6 22906985 1718414 Negative_regulation MAOA MAOB 24116298 204434 Negative_regulation MAOA MYLIP 24244526 2880377 Negative_regulation MAOA SIRT1 24244526 2880379 Negative_regulation MAOA SP1 22906985 1718409 Negative_regulation MAOA TPH1 24403876 685035 Negative_regulation MAOA TPH2 24403876 685036 Negative_regulation MAOB MAOA 24116298 204436 Negative_regulation MAP1LC3A EPHB2 24212825 498941 Negative_regulation MAP1LC3A NES 20352102 2444791 Negative_regulation MAP2 F2R 24705212 985504 Negative_regulation MAP2K1 ANO1 24639373 492648 Negative_regulation MAP2K1 CCND1 22833568 1806155 Negative_regulation MAP2K1 EPHB2 15743527 1036038 Negative_regulation MAP2K1 EPHB2 16351709 1844980 Negative_regulation MAP2K1 EPHB2 19834602 2428783 Negative_regulation MAP2K1 EPHB2 21119656 436263 Negative_regulation MAP2K1 EPHB2 21286247 1028366 Negative_regulation MAP2K1 EPHB2 22564882 2180041 Negative_regulation MAP2K1 EPHB2 22737061 2296760 Negative_regulation MAP2K1 EPHB2 22941289 15979 Negative_regulation MAP2K1 EPHB2 23271975 2340600 Negative_regulation MAP2K1 EPHB2 23469098 2761442 Negative_regulation MAP2K1 EPHB2 24223928 2877388 Negative_regulation MAP2K1 EPHB2 24384722 570754 Negative_regulation MAP2K1 EPHB2 24392034 2905378 Negative_regulation MAP2K1 EPHB2 24810962 2190479 Negative_regulation MAP2K1 EPHB2 24917786 931967 Negative_regulation MAP2K1 EPHB2 25063862 1502736 Negative_regulation MAP2K1 EPHB2 25165721 198192 Negative_regulation MAP2K1 EPHB2 25514788 3034701 Negative_regulation MAP2K1 FOXO1 18355401 1646196 Negative_regulation MAP2K1 FOXO1 20642839 1647307 Negative_regulation MAP2K1 FOXO1 21980390 2560174 Negative_regulation MAP2K1 FOXO1 22477519 1239012 Negative_regulation MAP2K1 IFI27 19015320 1361631 Negative_regulation MAP2K1 MAP2K6 21151481 2485029 Negative_regulation MAP2K1 MAP2K6 21286247 1028372 Negative_regulation MAP2K1 MAP2K6 21391908 692069 Negative_regulation MAP2K1 MAP2K6 23826126 2810459 Negative_regulation MAP2K1 MAP2K6 24588908 1872335 Negative_regulation MAP2K1 MAP2K6 24588908 1872336 Negative_regulation MAP2K1 MAP2K6 24917786 931973 Negative_regulation MAP2K1 MAP2K6 PMC4108878 1702718 Negative_regulation MAP2K1 SPHK1 23818902 2119894 Negative_regulation MAP2K1 SPHK1 24917786 931965 Negative_regulation MAP2K1 TLR7 20832340 1040216 Negative_regulation MAP2K1 TNF 19808894 711171 Negative_regulation MAP2K1 TNF 19808894 711422 Negative_regulation MAP2K1 TNF 21731751 2532413 Negative_regulation MAP2K2 ANO1 24639373 492649 Negative_regulation MAP2K2 CCND1 22833568 1806156 Negative_regulation MAP2K2 EPHB2 16351709 1844982 Negative_regulation MAP2K2 EPHB2 19834602 2428784 Negative_regulation MAP2K2 EPHB2 21119656 436264 Negative_regulation MAP2K2 EPHB2 22564882 2180042 Negative_regulation MAP2K2 EPHB2 22737061 2296761 Negative_regulation MAP2K2 EPHB2 22941289 15980 Negative_regulation MAP2K2 EPHB2 23271975 2340601 Negative_regulation MAP2K2 EPHB2 23469098 2761443 Negative_regulation MAP2K2 EPHB2 24810962 2190480 Negative_regulation MAP2K2 EPHB2 24917786 931979 Negative_regulation MAP2K2 EPHB2 25165721 198208 Negative_regulation MAP2K2 EPHB2 25514788 3034702 Negative_regulation MAP2K2 FOXO1 22477519 1239022 Negative_regulation MAP2K2 IFI27 19015320 1361632 Negative_regulation MAP2K2 SPHK1 23818902 2119895 Negative_regulation MAP2K2 SPHK1 24917786 931977 Negative_regulation MAP2K2 TNF 19808894 711174 Negative_regulation MAP2K2 TNF 19808894 711424 Negative_regulation MAP2K2 TNF 21731751 2532414 Negative_regulation MAP2K3 ANO1 24639373 492650 Negative_regulation MAP2K3 CCND1 22833568 1806157 Negative_regulation MAP2K3 EPHB2 16351709 1844984 Negative_regulation MAP2K3 EPHB2 19834602 2428785 Negative_regulation MAP2K3 EPHB2 21119656 436265 Negative_regulation MAP2K3 EPHB2 22564882 2180043 Negative_regulation MAP2K3 EPHB2 22737061 2296762 Negative_regulation MAP2K3 EPHB2 22941289 15981 Negative_regulation MAP2K3 EPHB2 23271975 2340602 Negative_regulation MAP2K3 EPHB2 23469098 2761444 Negative_regulation MAP2K3 EPHB2 24810962 2190481 Negative_regulation MAP2K3 EPHB2 24917786 931985 Negative_regulation MAP2K3 EPHB2 25165721 198224 Negative_regulation MAP2K3 EPHB2 25514788 3034703 Negative_regulation MAP2K3 FOXO1 22477519 1239032 Negative_regulation MAP2K3 IFI27 19015320 1361633 Negative_regulation MAP2K3 SPHK1 23818902 2119896 Negative_regulation MAP2K3 SPHK1 24917786 931983 Negative_regulation MAP2K3 TNF 19808894 711177 Negative_regulation MAP2K3 TNF 19808894 711426 Negative_regulation MAP2K3 TNF 21731751 2532415 Negative_regulation MAP2K4 ANO1 24639373 492651 Negative_regulation MAP2K4 CCND1 22833568 1806158 Negative_regulation MAP2K4 EPHB2 16351709 1844986 Negative_regulation MAP2K4 EPHB2 19834602 2428786 Negative_regulation MAP2K4 EPHB2 21119656 436266 Negative_regulation MAP2K4 EPHB2 22564882 2180044 Negative_regulation MAP2K4 EPHB2 22737061 2296763 Negative_regulation MAP2K4 EPHB2 22941289 15982 Negative_regulation MAP2K4 EPHB2 23271975 2340603 Negative_regulation MAP2K4 EPHB2 23469098 2761445 Negative_regulation MAP2K4 EPHB2 24810962 2190482 Negative_regulation MAP2K4 EPHB2 24917786 931991 Negative_regulation MAP2K4 EPHB2 25165721 198240 Negative_regulation MAP2K4 EPHB2 25514788 3034704 Negative_regulation MAP2K4 FOXO1 22477519 1239042 Negative_regulation MAP2K4 IFI27 19015320 1361634 Negative_regulation MAP2K4 SPHK1 23818902 2119897 Negative_regulation MAP2K4 SPHK1 24917786 931989 Negative_regulation MAP2K4 TNF 19808894 711180 Negative_regulation MAP2K4 TNF 19808894 711428 Negative_regulation MAP2K4 TNF 21731751 2532416 Negative_regulation MAP2K5 ANO1 24639373 492652 Negative_regulation MAP2K5 CCND1 22833568 1806159 Negative_regulation MAP2K5 EPHB2 16351709 1844988 Negative_regulation MAP2K5 EPHB2 19834602 2428787 Negative_regulation MAP2K5 EPHB2 21119656 436267 Negative_regulation MAP2K5 EPHB2 22564882 2180045 Negative_regulation MAP2K5 EPHB2 22737061 2296764 Negative_regulation MAP2K5 EPHB2 22941289 15983 Negative_regulation MAP2K5 EPHB2 23271975 2340604 Negative_regulation MAP2K5 EPHB2 23469098 2761446 Negative_regulation MAP2K5 EPHB2 24810962 2190483 Negative_regulation MAP2K5 EPHB2 24917786 931997 Negative_regulation MAP2K5 EPHB2 25165721 198256 Negative_regulation MAP2K5 EPHB2 25514788 3034705 Negative_regulation MAP2K5 FOXO1 22477519 1239052 Negative_regulation MAP2K5 IFI27 19015320 1361635 Negative_regulation MAP2K5 SPHK1 23818902 2119898 Negative_regulation MAP2K5 SPHK1 24917786 931995 Negative_regulation MAP2K5 TNF 19808894 711183 Negative_regulation MAP2K5 TNF 19808894 711430 Negative_regulation MAP2K5 TNF 21731751 2532417 Negative_regulation MAP2K6 AKT1 21887372 2549608 Negative_regulation MAP2K6 AKT1 21887372 2549645 Negative_regulation MAP2K6 AKT1 22477519 1239064 Negative_regulation MAP2K6 AKT1 22880048 2673660 Negative_regulation MAP2K6 AKT1 22880048 2673770 Negative_regulation MAP2K6 AKT1 24003303 649811 Negative_regulation MAP2K6 AKT1 24970815 2194129 Negative_regulation MAP2K6 AKT2 21887372 2549609 Negative_regulation MAP2K6 AKT2 21887372 2549646 Negative_regulation MAP2K6 AKT2 22477519 1239065 Negative_regulation MAP2K6 AKT2 22880048 2673661 Negative_regulation MAP2K6 AKT2 22880048 2673771 Negative_regulation MAP2K6 AKT2 24003303 649812 Negative_regulation MAP2K6 AKT2 24970815 2194130 Negative_regulation MAP2K6 AKT3 21887372 2549610 Negative_regulation MAP2K6 AKT3 21887372 2549647 Negative_regulation MAP2K6 AKT3 22477519 1239066 Negative_regulation MAP2K6 AKT3 22880048 2673662 Negative_regulation MAP2K6 AKT3 22880048 2673772 Negative_regulation MAP2K6 AKT3 24003303 649813 Negative_regulation MAP2K6 AKT3 24970815 2194131 Negative_regulation MAP2K6 AMELX 24810962 2190148 Negative_regulation MAP2K6 AMELX 24810962 2190192 Negative_regulation MAP2K6 ANO1 24639373 492653 Negative_regulation MAP2K6 ANXA6 23599172 2183038 Negative_regulation MAP2K6 ARAF 19247477 2406583 Negative_regulation MAP2K6 AREG 20034375 1676724 Negative_regulation MAP2K6 ATF3 22053207 2568041 Negative_regulation MAP2K6 ATF3 22053207 2568059 Negative_regulation MAP2K6 ATF3 22751695 723526 Negative_regulation MAP2K6 ATG4B 24240988 1939529 Negative_regulation MAP2K6 BANF1 22046349 2566786 Negative_regulation MAP2K6 BCRP1 23320839 482911 Negative_regulation MAP2K6 BCRP2 23320839 482907 Negative_regulation MAP2K6 BCRP3 23320839 482908 Negative_regulation MAP2K6 BCRP4 23320839 482909 Negative_regulation MAP2K6 BCRP5 23320839 482910 Negative_regulation MAP2K6 BCRP6 23320839 482912 Negative_regulation MAP2K6 BCRP7 23320839 482913 Negative_regulation MAP2K6 BCRP8 23320839 482914 Negative_regulation MAP2K6 BCRP9 23320839 482915 Negative_regulation MAP2K6 BRAF 17958888 1242775 Negative_regulation MAP2K6 BRAF 21505228 2175876 Negative_regulation MAP2K6 BRAF 23085539 2181374 Negative_regulation MAP2K6 BRAF 24693430 155797 Negative_regulation MAP2K6 BRAF 24810962 2190460 Negative_regulation MAP2K6 BRAF 25344914 2206113 Negative_regulation MAP2K6 BRAF 25435907 745951 Negative_regulation MAP2K6 BRAP 23105109 1205466 Negative_regulation MAP2K6 BRD7 19949542 672201 Negative_regulation MAP2K6 CASP8 15266324 424816 Negative_regulation MAP2K6 CASP9 21637382 1686173 Negative_regulation MAP2K6 CAV1 24011378 3114071 Negative_regulation MAP2K6 CAV1 24011378 3114072 Negative_regulation MAP2K6 CAV1 24011378 3114081 Negative_regulation MAP2K6 CAV1 24011378 3114125 Negative_regulation MAP2K6 CCND1 22833568 1806160 Negative_regulation MAP2K6 CD24 22400115 154677 Negative_regulation MAP2K6 CDH1 24318272 2186011 Negative_regulation MAP2K6 CDH1 25375090 2206998 Negative_regulation MAP2K6 CDKN1A 16351709 1844989 Negative_regulation MAP2K6 CDKN1A 25309914 201083 Negative_regulation MAP2K6 CDKN1B 24563807 1242102 Negative_regulation MAP2K6 CHUK 23826126 2810318 Negative_regulation MAP2K6 CRK 16275761 1538238 Negative_regulation MAP2K6 CRK 24340098 2895131 Negative_regulation MAP2K6 CRK 25165721 198270 Negative_regulation MAP2K6 CRKL 16275761 1538239 Negative_regulation MAP2K6 CTLA4 22594466 1639780 Negative_regulation MAP2K6 CYP2E1 22028977 1078809 Negative_regulation MAP2K6 DCC 24009732 2841423 Negative_regulation MAP2K6 DPYD 20141835 516338 Negative_regulation MAP2K6 EGF 21666717 2140068 Negative_regulation MAP2K6 EGF 21666717 2140183 Negative_regulation MAP2K6 EGF 25246767 743250 Negative_regulation MAP2K6 EGFR 17663798 320708 Negative_regulation MAP2K6 EGFR 21333004 404430 Negative_regulation MAP2K6 EGFR 23143667 2172100 Negative_regulation MAP2K6 EPHB2 16351709 1844990 Negative_regulation MAP2K6 EPHB2 19834602 2428788 Negative_regulation MAP2K6 EPHB2 21119656 436268 Negative_regulation MAP2K6 EPHB2 22564882 2180046 Negative_regulation MAP2K6 EPHB2 22737061 2296765 Negative_regulation MAP2K6 EPHB2 22941289 15984 Negative_regulation MAP2K6 EPHB2 23271975 2340605 Negative_regulation MAP2K6 EPHB2 23469098 2761447 Negative_regulation MAP2K6 EPHB2 24810962 2190484 Negative_regulation MAP2K6 EPHB2 24917786 932003 Negative_regulation MAP2K6 EPHB2 25165721 198272 Negative_regulation MAP2K6 EPHB2 25514788 3034706 Negative_regulation MAP2K6 ERF 23509960 1666145 Negative_regulation MAP2K6 ETS1 25294825 2105150 Negative_regulation MAP2K6 ETS1 25294825 2105151 Negative_regulation MAP2K6 FGF1 22276221 2590603 Negative_regulation MAP2K6 FGF1 23300662 2734568 Negative_regulation MAP2K6 FGF10 22276221 2590604 Negative_regulation MAP2K6 FGF10 23300662 2734569 Negative_regulation MAP2K6 FGF11 22276221 2590605 Negative_regulation MAP2K6 FGF11 23300662 2734570 Negative_regulation MAP2K6 FGF12 22276221 2590606 Negative_regulation MAP2K6 FGF12 23300662 2734571 Negative_regulation MAP2K6 FGF13 22276221 2590607 Negative_regulation MAP2K6 FGF13 23300662 2734572 Negative_regulation MAP2K6 FGF14 22276221 2590608 Negative_regulation MAP2K6 FGF14 23300662 2734573 Negative_regulation MAP2K6 FGF16 22276221 2590609 Negative_regulation MAP2K6 FGF16 23300662 2734574 Negative_regulation MAP2K6 FGF17 22276221 2590610 Negative_regulation MAP2K6 FGF17 23300662 2734575 Negative_regulation MAP2K6 FGF18 22276221 2590611 Negative_regulation MAP2K6 FGF18 23300662 2734576 Negative_regulation MAP2K6 FGF19 22276221 2590612 Negative_regulation MAP2K6 FGF19 23300662 2734577 Negative_regulation MAP2K6 FGF2 21347602 3170147 Negative_regulation MAP2K6 FGF2 22276221 2590613 Negative_regulation MAP2K6 FGF2 23300662 2734578 Negative_regulation MAP2K6 FGF2 23919458 294638 Negative_regulation MAP2K6 FGF20 22276221 2590614 Negative_regulation MAP2K6 FGF20 23300662 2734579 Negative_regulation MAP2K6 FGF21 22276221 2590615 Negative_regulation MAP2K6 FGF21 23300662 2734580 Negative_regulation MAP2K6 FGF22 22276221 2590616 Negative_regulation MAP2K6 FGF22 23300662 2734581 Negative_regulation MAP2K6 FGF23 22276221 2590617 Negative_regulation MAP2K6 FGF23 23300662 2734582 Negative_regulation MAP2K6 FGF3 22276221 2590618 Negative_regulation MAP2K6 FGF3 23300662 2734583 Negative_regulation MAP2K6 FGF4 22276221 2590619 Negative_regulation MAP2K6 FGF4 23300662 2734584 Negative_regulation MAP2K6 FGF5 22276221 2590620 Negative_regulation MAP2K6 FGF5 23300662 2734585 Negative_regulation MAP2K6 FGF6 22276221 2590621 Negative_regulation MAP2K6 FGF6 23300662 2734586 Negative_regulation MAP2K6 FGF7 22276221 2590622 Negative_regulation MAP2K6 FGF7 23300662 2734587 Negative_regulation MAP2K6 FGF8 22276221 2590623 Negative_regulation MAP2K6 FGF8 23300662 2734588 Negative_regulation MAP2K6 FGF9 22276221 2590624 Negative_regulation MAP2K6 FGF9 23300662 2734589 Negative_regulation MAP2K6 FLT3 21453545 1616426 Negative_regulation MAP2K6 FOXO1 22477519 1239062 Negative_regulation MAP2K6 FOXO3 22477519 1239063 Negative_regulation MAP2K6 FOXO4 22477519 1239068 Negative_regulation MAP2K6 FOXO6 22477519 1239061 Negative_regulation MAP2K6 GATA1 25149543 2198593 Negative_regulation MAP2K6 GRAP2 25165721 198273 Negative_regulation MAP2K6 HPD 24058766 1705316 Negative_regulation MAP2K6 HRAS 12370245 1286893 Negative_regulation MAP2K6 HRAS 21151481 2485048 Negative_regulation MAP2K6 HRAS 24392017 2905210 Negative_regulation MAP2K6 HSPG2 20924352 1903829 Negative_regulation MAP2K6 IFI27 19015320 1361636 Negative_regulation MAP2K6 IGFBP7 20158915 1504050 Negative_regulation MAP2K6 IGFBP7 25212428 1685517 Negative_regulation MAP2K6 IKBKB 23826126 2810319 Negative_regulation MAP2K6 IKBKG 23826126 2810320 Negative_regulation MAP2K6 IL1A 19808894 711187 Negative_regulation MAP2K6 IL1A 19808894 711433 Negative_regulation MAP2K6 INS 19808894 711188 Negative_regulation MAP2K6 INS 22031825 2565217 Negative_regulation MAP2K6 IRS1 22477519 1239067 Negative_regulation MAP2K6 JAK1 23300886 2737177 Negative_regulation MAP2K6 JAK2 23300886 2737178 Negative_regulation MAP2K6 JAK3 23300886 2737179 Negative_regulation MAP2K6 KRAS 12370245 1286894 Negative_regulation MAP2K6 KRAS 21151481 2485049 Negative_regulation MAP2K6 KRAS 24392017 2905211 Negative_regulation MAP2K6 LBH 22039466 2565555 Negative_regulation MAP2K6 LCK 22413885 355166 Negative_regulation MAP2K6 LIF 21347602 3170148 Negative_regulation MAP2K6 LIF 21798094 3160327 Negative_regulation MAP2K6 LIF 24371807 3166235 Negative_regulation MAP2K6 LIF 24957798 3142751 Negative_regulation MAP2K6 MAP2K1 21151481 2485050 Negative_regulation MAP2K6 MAP2K1 24588908 1872343 Negative_regulation MAP2K6 MAP2K1 24917786 932004 Negative_regulation MAP2K6 MAP3K8 15699069 1534463 Negative_regulation MAP2K6 MAPK1 19156138 431664 Negative_regulation MAP2K6 MAPK1 19619605 833423 Negative_regulation MAP2K6 MAPK1 19852815 326733 Negative_regulation MAP2K6 MAPK1 23667660 2791068 Negative_regulation MAP2K6 MAPK1 24294133 3155360 Negative_regulation MAP2K6 MAPK1 24340098 2895133 Negative_regulation MAP2K6 MAPK1 25165721 198274 Negative_regulation MAP2K6 MAPK10 19156138 431665 Negative_regulation MAP2K6 MAPK10 19852815 326734 Negative_regulation MAP2K6 MAPK10 23667660 2791069 Negative_regulation MAP2K6 MAPK10 24294133 3155361 Negative_regulation MAP2K6 MAPK10 24340098 2895134 Negative_regulation MAP2K6 MAPK10 25165721 198275 Negative_regulation MAP2K6 MAPK11 19156138 431666 Negative_regulation MAP2K6 MAPK11 19852815 326735 Negative_regulation MAP2K6 MAPK11 23667660 2791070 Negative_regulation MAP2K6 MAPK11 24294133 3155362 Negative_regulation MAP2K6 MAPK11 24340098 2895135 Negative_regulation MAP2K6 MAPK11 25165721 198276 Negative_regulation MAP2K6 MAPK12 19156138 431667 Negative_regulation MAP2K6 MAPK12 19852815 326736 Negative_regulation MAP2K6 MAPK12 23667660 2791071 Negative_regulation MAP2K6 MAPK12 24294133 3155363 Negative_regulation MAP2K6 MAPK12 24340098 2895136 Negative_regulation MAP2K6 MAPK12 25165721 198277 Negative_regulation MAP2K6 MAPK13 19156138 431668 Negative_regulation MAP2K6 MAPK13 19852815 326737 Negative_regulation MAP2K6 MAPK13 23667660 2791072 Negative_regulation MAP2K6 MAPK13 24294133 3155364 Negative_regulation MAP2K6 MAPK13 24340098 2895137 Negative_regulation MAP2K6 MAPK13 25165721 198278 Negative_regulation MAP2K6 MAPK14 19156138 431669 Negative_regulation MAP2K6 MAPK14 19852815 326738 Negative_regulation MAP2K6 MAPK14 23667660 2791073 Negative_regulation MAP2K6 MAPK14 24294133 3155365 Negative_regulation MAP2K6 MAPK14 24340098 2895138 Negative_regulation MAP2K6 MAPK14 25165721 198279 Negative_regulation MAP2K6 MAPK15 19156138 431663 Negative_regulation MAP2K6 MAPK15 19852815 326732 Negative_regulation MAP2K6 MAPK15 23667660 2791067 Negative_regulation MAP2K6 MAPK15 24294133 3155359 Negative_regulation MAP2K6 MAPK15 24340098 2895132 Negative_regulation MAP2K6 MAPK15 25165721 198271 Negative_regulation MAP2K6 MAPK3 19156138 431670 Negative_regulation MAP2K6 MAPK3 19619605 833424 Negative_regulation MAP2K6 MAPK3 19852815 326739 Negative_regulation MAP2K6 MAPK3 21998720 2562227 Negative_regulation MAP2K6 MAPK3 22031842 2565325 Negative_regulation MAP2K6 MAPK3 23667660 2791074 Negative_regulation MAP2K6 MAPK3 23734197 2799584 Negative_regulation MAP2K6 MAPK3 24294133 3155366 Negative_regulation MAP2K6 MAPK3 24340098 2895139 Negative_regulation MAP2K6 MAPK3 25165721 198280 Negative_regulation MAP2K6 MAPK4 19156138 431671 Negative_regulation MAP2K6 MAPK4 19852815 326740 Negative_regulation MAP2K6 MAPK4 23667660 2791075 Negative_regulation MAP2K6 MAPK4 24294133 3155367 Negative_regulation MAP2K6 MAPK4 24340098 2895140 Negative_regulation MAP2K6 MAPK4 25165721 198281 Negative_regulation MAP2K6 MAPK6 19156138 431672 Negative_regulation MAP2K6 MAPK6 19852815 326741 Negative_regulation MAP2K6 MAPK6 23667660 2791076 Negative_regulation MAP2K6 MAPK6 24294133 3155368 Negative_regulation MAP2K6 MAPK6 24340098 2895141 Negative_regulation MAP2K6 MAPK6 25165721 198282 Negative_regulation MAP2K6 MAPK7 19156138 431673 Negative_regulation MAP2K6 MAPK7 19852815 326742 Negative_regulation MAP2K6 MAPK7 23667660 2791077 Negative_regulation MAP2K6 MAPK7 24294133 3155369 Negative_regulation MAP2K6 MAPK7 24340098 2895142 Negative_regulation MAP2K6 MAPK7 25165721 198283 Negative_regulation MAP2K6 MAPK8 19156138 431674 Negative_regulation MAP2K6 MAPK8 19852815 326743 Negative_regulation MAP2K6 MAPK8 23667660 2791078 Negative_regulation MAP2K6 MAPK8 24294133 3155370 Negative_regulation MAP2K6 MAPK8 24340098 2895143 Negative_regulation MAP2K6 MAPK8 25165721 198284 Negative_regulation MAP2K6 MAPK9 19156138 431675 Negative_regulation MAP2K6 MAPK9 19852815 326744 Negative_regulation MAP2K6 MAPK9 23667660 2791079 Negative_regulation MAP2K6 MAPK9 24294133 3155371 Negative_regulation MAP2K6 MAPK9 24340098 2895144 Negative_regulation MAP2K6 MAPK9 25165721 198285 Negative_regulation MAP2K6 MAPKAPK2 24917786 932005 Negative_regulation MAP2K6 ME2 23118220 1205538 Negative_regulation MAP2K6 METAP2 24498386 2919562 Negative_regulation MAP2K6 MKNK1 24917786 932006 Negative_regulation MAP2K6 MLN 25074438 1702411 Negative_regulation MAP2K6 MLST8 22808163 2664904 Negative_regulation MAP2K6 MMP9 19852815 326745 Negative_regulation MAP2K6 MSC 21750552 437094 Negative_regulation MAP2K6 MSC 21750552 437101 Negative_regulation MAP2K6 MSC 23085539 2181527 Negative_regulation MAP2K6 MSC 25051360 2196641 Negative_regulation MAP2K6 MSC 25344914 2205979 Negative_regulation MAP2K6 MTOR 21484200 1652979 Negative_regulation MAP2K6 MTOR 22401294 263975 Negative_regulation MAP2K6 MTOR 22808163 2664906 Negative_regulation MAP2K6 MTOR 23676467 2183303 Negative_regulation MAP2K6 MTOR 24212820 498809 Negative_regulation MAP2K6 MTOR 25180793 3004352 Negative_regulation MAP2K6 MTOR 25180793 3004360 Negative_regulation MAP2K6 MUC1 25245423 2201659 Negative_regulation MAP2K6 NF1 19901965 2128132 Negative_regulation MAP2K6 NF1 24709709 617168 Negative_regulation MAP2K6 NF1 25535838 762930 Negative_regulation MAP2K6 NPY4R 21811441 933322 Negative_regulation MAP2K6 NPY4R 23424645 2755042 Negative_regulation MAP2K6 NPY6R 22254061 2116056 Negative_regulation MAP2K6 NPY6R 22747893 1664243 Negative_regulation MAP2K6 NPY6R 24759913 2957832 Negative_regulation MAP2K6 NRAS 12370245 1286895 Negative_regulation MAP2K6 NRAS 20141835 516352 Negative_regulation MAP2K6 NRAS 21151481 2485051 Negative_regulation MAP2K6 NRAS 24392017 2905212 Negative_regulation MAP2K6 PDB1 24339963 2894426 Negative_regulation MAP2K6 PEBP1 20378935 27168 Negative_regulation MAP2K6 PEBP1 24209905 270383 Negative_regulation MAP2K6 PEBP1 24209905 270391 Negative_regulation MAP2K6 PEBP1 25435928 2170180 Negative_regulation MAP2K6 PHB 24096434 93500 Negative_regulation MAP2K6 PI3 20041180 2435775 Negative_regulation MAP2K6 PI3 23305385 127677 Negative_regulation MAP2K6 PIK3CA 15689238 382685 Negative_regulation MAP2K6 PIK3CA 20712893 1858067 Negative_regulation MAP2K6 PIK3CA 20712893 1858124 Negative_regulation MAP2K6 PIK3CA 21505228 2175841 Negative_regulation MAP2K6 PIK3CA 22477519 1239069 Negative_regulation MAP2K6 PIK3CA 22536370 2622127 Negative_regulation MAP2K6 PIK3CA 22860103 2671689 Negative_regulation MAP2K6 PIK3CA 23535559 1721087 Negative_regulation MAP2K6 PIK3CA 24272818 2185587 Negative_regulation MAP2K6 PIK3CA 24384723 570800 Negative_regulation MAP2K6 PIK3CA 24413464 3139277 Negative_regulation MAP2K6 PIK3CA 24807215 1941986 Negative_regulation MAP2K6 PIK3CA 24810962 2190149 Negative_regulation MAP2K6 PIK3CA 24810962 2190258 Negative_regulation MAP2K6 PIK3R1 15689238 382686 Negative_regulation MAP2K6 PIK3R1 20712893 1858068 Negative_regulation MAP2K6 PIK3R1 20712893 1858125 Negative_regulation MAP2K6 PIK3R1 21505228 2175842 Negative_regulation MAP2K6 PIK3R1 22477519 1239070 Negative_regulation MAP2K6 PIK3R1 22536370 2622128 Negative_regulation MAP2K6 PIK3R1 22860103 2671690 Negative_regulation MAP2K6 PIK3R1 23535559 1721088 Negative_regulation MAP2K6 PIK3R1 24272818 2185588 Negative_regulation MAP2K6 PIK3R1 24384723 570801 Negative_regulation MAP2K6 PIK3R1 24413464 3139278 Negative_regulation MAP2K6 PIK3R1 24810962 2190150 Negative_regulation MAP2K6 PIK3R1 24810962 2190259 Negative_regulation MAP2K6 PPM1D 23907458 564418 Negative_regulation MAP2K6 PRKACB 22384111 2603956 Negative_regulation MAP2K6 PRKACB 22384111 2605843 Negative_regulation MAP2K6 PRKACB 22384111 2605897 Negative_regulation MAP2K6 PRKACG 22384111 2603957 Negative_regulation MAP2K6 PRKACG 22384111 2605844 Negative_regulation MAP2K6 PRKACG 22384111 2605898 Negative_regulation MAP2K6 PRKAR1A 22384111 2603958 Negative_regulation MAP2K6 PRKAR1A 22384111 2605845 Negative_regulation MAP2K6 PRKAR1A 22384111 2605899 Negative_regulation MAP2K6 PRKAR1B 22384111 2603959 Negative_regulation MAP2K6 PRKAR1B 22384111 2605846 Negative_regulation MAP2K6 PRKAR1B 22384111 2605900 Negative_regulation MAP2K6 PRKAR2A 22384111 2603960 Negative_regulation MAP2K6 PRKAR2A 22384111 2605847 Negative_regulation MAP2K6 PRKAR2A 22384111 2605901 Negative_regulation MAP2K6 PRKAR2B 22384111 2603961 Negative_regulation MAP2K6 PRKAR2B 22384111 2605848 Negative_regulation MAP2K6 PRKAR2B 22384111 2605902 Negative_regulation MAP2K6 PSIP1 22046349 2566787 Negative_regulation MAP2K6 PTPN13 19734941 2126771 Negative_regulation MAP2K6 PTPN13 PMC4261712 1049455 Negative_regulation MAP2K6 PTPN3 20353590 1626002 Negative_regulation MAP2K6 PTX3 21686182 1091098 Negative_regulation MAP2K6 PTX4 21686182 1091097 Negative_regulation MAP2K6 RAF1 17958888 1242777 Negative_regulation MAP2K6 RANBP9 23118896 2711949 Negative_regulation MAP2K6 RICTOR 22808163 2664905 Negative_regulation MAP2K6 ROCK1 22195035 2583815 Negative_regulation MAP2K6 ROCK2 22195035 2583816 Negative_regulation MAP2K6 SCRIB 23359326 2744929 Negative_regulation MAP2K6 SH2B1 22539954 2622595 Negative_regulation MAP2K6 SIX1 22765220 471698 Negative_regulation MAP2K6 SLC25A16 20049713 774321 Negative_regulation MAP2K6 SLC25A16 22415236 438373 Negative_regulation MAP2K6 SLC25A16 22551296 1698317 Negative_regulation MAP2K6 SLC25A16 23658859 943521 Negative_regulation MAP2K6 SLC25A16 24339963 2894425 Negative_regulation MAP2K6 SLC25A16 24693430 155790 Negative_regulation MAP2K6 SLC25A16 24966667 743136 Negative_regulation MAP2K6 SLC25A16 24966667 743143 Negative_regulation MAP2K6 SLC25A16 25278770 2123317 Negative_regulation MAP2K6 SLC25A16 25344914 2205978 Negative_regulation MAP2K6 SMAD1 22614218 2170946 Negative_regulation MAP2K6 SMAD2 22614218 2170947 Negative_regulation MAP2K6 SMAD3 22614218 2170948 Negative_regulation MAP2K6 SMAD4 20712893 1858066 Negative_regulation MAP2K6 SMAD4 20712893 1858123 Negative_regulation MAP2K6 SMAD4 22614218 2170949 Negative_regulation MAP2K6 SMAD5 22614218 2170950 Negative_regulation MAP2K6 SMAD6 22614218 2170951 Negative_regulation MAP2K6 SMAD7 22614218 2170952 Negative_regulation MAP2K6 SMAD9 22614218 2170953 Negative_regulation MAP2K6 SPHK1 23818902 2119899 Negative_regulation MAP2K6 SPHK1 24917786 932001 Negative_regulation MAP2K6 SPHK2 24917786 932002 Negative_regulation MAP2K6 SPP1 20868520 1859585 Negative_regulation MAP2K6 SPRY1 11238463 1267795 Negative_regulation MAP2K6 SPRY2 11238463 1267796 Negative_regulation MAP2K6 SRC 22284833 805792 Negative_regulation MAP2K6 STAT3 24970815 2194332 Negative_regulation MAP2K6 STK3 22035226 528040 Negative_regulation MAP2K6 SULT1A1 16705314 427723 Negative_regulation MAP2K6 TGM5 21945811 159907 Negative_regulation MAP2K6 TNF 19808894 711186 Negative_regulation MAP2K6 TNF 19808894 711432 Negative_regulation MAP2K6 TNF 21731751 2532418 Negative_regulation MAP2K6 TREM2 21861861 123790 Negative_regulation MAP2K6 UCN 16705314 427724 Negative_regulation MAP2K6 USP15 23105109 1205390 Negative_regulation MAP2K6 VEGFA 23049945 2699884 Negative_regulation MAP2K6 WNT1 22701736 2652457 Negative_regulation MAP2K6 WNT11 22701736 2652458 Negative_regulation MAP2K6 WNT16 22701736 2652463 Negative_regulation MAP2K6 WNT2 22701736 2652459 Negative_regulation MAP2K6 WNT3 22701736 2652460 Negative_regulation MAP2K6 WNT4 22701736 2652461 Negative_regulation MAP2K6 WNT6 22701736 2652462 Negative_regulation MAP2K6 YWHAB 17958888 1242776 Negative_regulation MAP2K7 ANO1 24639373 492654 Negative_regulation MAP2K7 CCND1 22833568 1806161 Negative_regulation MAP2K7 EPHB2 16351709 1844992 Negative_regulation MAP2K7 EPHB2 19834602 2428789 Negative_regulation MAP2K7 EPHB2 21119656 436269 Negative_regulation MAP2K7 EPHB2 22564882 2180047 Negative_regulation MAP2K7 EPHB2 22737061 2296766 Negative_regulation MAP2K7 EPHB2 22941289 15985 Negative_regulation MAP2K7 EPHB2 23271975 2340606 Negative_regulation MAP2K7 EPHB2 23469098 2761448 Negative_regulation MAP2K7 EPHB2 24810962 2190485 Negative_regulation MAP2K7 EPHB2 24917786 932009 Negative_regulation MAP2K7 EPHB2 25165721 198288 Negative_regulation MAP2K7 EPHB2 25514788 3034707 Negative_regulation MAP2K7 FOXO1 22477519 1239072 Negative_regulation MAP2K7 IFI27 19015320 1361637 Negative_regulation MAP2K7 SPHK1 23818902 2119900 Negative_regulation MAP2K7 SPHK1 24917786 932007 Negative_regulation MAP2K7 TNF 19808894 711189 Negative_regulation MAP2K7 TNF 19808894 711434 Negative_regulation MAP2K7 TNF 21731751 2532419 Negative_regulation MAP3K10 EPHB2 25155142 1917712 Negative_regulation MAP3K5 TNF 22046421 2567714 Negative_regulation MAP3K5 TNF 24457959 571492 Negative_regulation MAP3K7 NEDD9 24980047 1576871 Negative_regulation MAP3K8 MAP2K6 15699069 1534470 Negative_regulation MAP3K8 NEDD9 23527104 2769478 Negative_regulation MAP3K8 NEDD9 24980047 1576872 Negative_regulation MAP3K8 TNF 15575964 1844339 Negative_regulation MAP3K9 MAP2K6 24849047 1942125 Negative_regulation MAPK1 ARSA 24039842 2844907 Negative_regulation MAPK1 CCND1 19015320 1361434 Negative_regulation MAPK1 CD14 20011115 3045913 Negative_regulation MAPK1 CTGF 19852794 1227673 Negative_regulation MAPK1 CTGF 19852794 1227674 Negative_regulation MAPK1 EPHB2 12769834 369116 Negative_regulation MAPK1 EPHB2 19047466 1362066 Negative_regulation MAPK1 EPHB2 19821775 1236738 Negative_regulation MAPK1 EPHB2 20093365 1169055 Negative_regulation MAPK1 EPHB2 20526329 1924855 Negative_regulation MAPK1 EPHB2 20593014 2454317 Negative_regulation MAPK1 EPHB2 21120149 860383 Negative_regulation MAPK1 EPHB2 21162728 2232975 Negative_regulation MAPK1 EPHB2 21317295 717830 Negative_regulation MAPK1 EPHB2 21317295 717904 Negative_regulation MAPK1 EPHB2 21685889 1926360 Negative_regulation MAPK1 EPHB2 22367739 778328 Negative_regulation MAPK1 EPHB2 22413885 355168 Negative_regulation MAPK1 EPHB2 22447027 1956956 Negative_regulation MAPK1 EPHB2 22447027 1956957 Negative_regulation MAPK1 EPHB2 22567028 634411 Negative_regulation MAPK1 EPHB2 22675451 2648422 Negative_regulation MAPK1 EPHB2 22675451 2648486 Negative_regulation MAPK1 EPHB2 22723883 2654995 Negative_regulation MAPK1 EPHB2 22952896 2684861 Negative_regulation MAPK1 EPHB2 24340098 2895161 Negative_regulation MAPK1 EPHB2 25165721 198303 Negative_regulation MAPK1 EPHB2 25372283 3022983 Negative_regulation MAPK1 EPHB2 PMC3760629 1606146 Negative_regulation MAPK1 F2R 21378407 2175427 Negative_regulation MAPK1 FAS 21477291 527153 Negative_regulation MAPK1 HBEGF 22984591 2689345 Negative_regulation MAPK1 MAP2K6 10769026 1257121 Negative_regulation MAPK1 MAP2K6 11034602 1517623 Negative_regulation MAPK1 MAP2K6 16103225 1323155 Negative_regulation MAPK1 MAP2K6 19619605 833432 Negative_regulation MAPK1 MAP2K6 19852815 326765 Negative_regulation MAPK1 MAP2K6 20955562 120501 Negative_regulation MAPK1 MAP2K6 22413885 355175 Negative_regulation MAPK1 MAP2K6 22415879 721932 Negative_regulation MAPK1 MAP2K6 22870983 288848 Negative_regulation MAPK1 MAP2K6 23390495 2750730 Negative_regulation MAPK1 MAP2K6 24232636 2235868 Negative_regulation MAPK1 MAP2K6 24294133 3155390 Negative_regulation MAPK1 MAP2K6 24340098 2895167 Negative_regulation MAPK1 MAP2K6 24588908 1872362 Negative_regulation MAPK1 MAP2K6 25165721 198310 Negative_regulation MAPK1 MAP2K6 25200404 3145376 Negative_regulation MAPK1 MUC16 22977714 646599 Negative_regulation MAPK1 NES 22419908 951387 Negative_regulation MAPK1 PECAM1 12177047 1286347 Negative_regulation MAPK1 PTGER2 25327961 216533 Negative_regulation MAPK1 RASD1 24817889 1070777 Negative_regulation MAPK1 RCAN1 19124655 1553324 Negative_regulation MAPK1 RGS2 18067675 461929 Negative_regulation MAPK1 RGS2 24743392 2955280 Negative_regulation MAPK1 RGS2 24743392 2955281 Negative_regulation MAPK1 RGS2 24743392 2955429 Negative_regulation MAPK1 RGS2 24743392 2955458 Negative_regulation MAPK1 SARM1 24505321 2920584 Negative_regulation MAPK1 SPHK1 20634980 2455776 Negative_regulation MAPK1 STK39 17988378 392899 Negative_regulation MAPK1 TLR7 22829768 3058218 Negative_regulation MAPK1 TNF 14613529 3095407 Negative_regulation MAPK1 TNF 15175101 523607 Negative_regulation MAPK1 TNF 21871121 1659612 Negative_regulation MAPK1 TNF 22675384 814608 Negative_regulation MAPK1 TNF 23784308 606084 Negative_regulation MAPK1 TNF 24304472 1482094 Negative_regulation MAPK1 TNF 24740309 2954639 Negative_regulation MAPK1 TNF 25364728 861725 Negative_regulation MAPK10 ARSA 24039842 2844909 Negative_regulation MAPK10 CCND1 19015320 1361437 Negative_regulation MAPK10 CD14 20011115 3045914 Negative_regulation MAPK10 CTGF 19852794 1227675 Negative_regulation MAPK10 CTGF 19852794 1227676 Negative_regulation MAPK10 EPHB2 19047466 1362067 Negative_regulation MAPK10 EPHB2 19821775 1236739 Negative_regulation MAPK10 EPHB2 20093365 1169060 Negative_regulation MAPK10 EPHB2 20526329 1924857 Negative_regulation MAPK10 EPHB2 20593014 2454318 Negative_regulation MAPK10 EPHB2 21120149 860384 Negative_regulation MAPK10 EPHB2 21162728 2232976 Negative_regulation MAPK10 EPHB2 21317295 717832 Negative_regulation MAPK10 EPHB2 21317295 717905 Negative_regulation MAPK10 EPHB2 21685889 1926361 Negative_regulation MAPK10 EPHB2 22367739 778329 Negative_regulation MAPK10 EPHB2 22413885 355177 Negative_regulation MAPK10 EPHB2 22447027 1956958 Negative_regulation MAPK10 EPHB2 22447027 1956959 Negative_regulation MAPK10 EPHB2 22567028 634412 Negative_regulation MAPK10 EPHB2 22675451 2648423 Negative_regulation MAPK10 EPHB2 22675451 2648487 Negative_regulation MAPK10 EPHB2 22723883 2654996 Negative_regulation MAPK10 EPHB2 22952896 2684862 Negative_regulation MAPK10 EPHB2 24340098 2895173 Negative_regulation MAPK10 EPHB2 25165721 198313 Negative_regulation MAPK10 EPHB2 25372283 3022984 Negative_regulation MAPK10 EPHB2 PMC3760629 1606149 Negative_regulation MAPK10 F2R 21378407 2175428 Negative_regulation MAPK10 FAS 21477291 527154 Negative_regulation MAPK10 MAP2K6 11034602 1517630 Negative_regulation MAPK10 MAP2K6 19852815 326772 Negative_regulation MAPK10 MAP2K6 20955562 120503 Negative_regulation MAPK10 MAP2K6 22413885 355184 Negative_regulation MAPK10 MAP2K6 22415879 721935 Negative_regulation MAPK10 MAP2K6 22870983 288849 Negative_regulation MAPK10 MAP2K6 23390495 2750737 Negative_regulation MAPK10 MAP2K6 24232636 2235869 Negative_regulation MAPK10 MAP2K6 24294133 3155398 Negative_regulation MAPK10 MAP2K6 24340098 2895179 Negative_regulation MAPK10 MAP2K6 24588908 1872369 Negative_regulation MAPK10 MAP2K6 25165721 198320 Negative_regulation MAPK10 MAP2K6 25200404 3145377 Negative_regulation MAPK10 MUC16 22977714 646600 Negative_regulation MAPK10 PTGER2 25327961 216534 Negative_regulation MAPK10 RASD1 24817889 1070778 Negative_regulation MAPK10 RCAN1 19124655 1553325 Negative_regulation MAPK10 RGS2 18067675 461930 Negative_regulation MAPK10 RGS2 24743392 2955284 Negative_regulation MAPK10 RGS2 24743392 2955285 Negative_regulation MAPK10 RGS2 24743392 2955431 Negative_regulation MAPK10 RGS2 24743392 2955460 Negative_regulation MAPK10 SARM1 24505321 2920585 Negative_regulation MAPK10 STK39 17988378 392914 Negative_regulation MAPK10 TLR7 22829768 3058228 Negative_regulation MAPK10 TNF 14613529 3095408 Negative_regulation MAPK10 TNF 15175101 523608 Negative_regulation MAPK10 TNF 21871121 1659613 Negative_regulation MAPK10 TNF 22675384 814610 Negative_regulation MAPK10 TNF 23784308 606085 Negative_regulation MAPK10 TNF 24304472 1482095 Negative_regulation MAPK10 TNF 24740309 2954640 Negative_regulation MAPK10 TNF 25364728 861726 Negative_regulation MAPK11 ARSA 24039842 2844911 Negative_regulation MAPK11 CCND1 19015320 1361440 Negative_regulation MAPK11 CD14 20011115 3045915 Negative_regulation MAPK11 CTGF 19852794 1227677 Negative_regulation MAPK11 CTGF 19852794 1227678 Negative_regulation MAPK11 EPHB2 19047466 1362068 Negative_regulation MAPK11 EPHB2 19821775 1236740 Negative_regulation MAPK11 EPHB2 20093365 1169065 Negative_regulation MAPK11 EPHB2 20526329 1924859 Negative_regulation MAPK11 EPHB2 20593014 2454319 Negative_regulation MAPK11 EPHB2 21120149 860385 Negative_regulation MAPK11 EPHB2 21162728 2232977 Negative_regulation MAPK11 EPHB2 21317295 717834 Negative_regulation MAPK11 EPHB2 21317295 717906 Negative_regulation MAPK11 EPHB2 21685889 1926362 Negative_regulation MAPK11 EPHB2 22367739 778330 Negative_regulation MAPK11 EPHB2 22413885 355186 Negative_regulation MAPK11 EPHB2 22447027 1956960 Negative_regulation MAPK11 EPHB2 22447027 1956961 Negative_regulation MAPK11 EPHB2 22567028 634413 Negative_regulation MAPK11 EPHB2 22675451 2648424 Negative_regulation MAPK11 EPHB2 22675451 2648488 Negative_regulation MAPK11 EPHB2 22723883 2654997 Negative_regulation MAPK11 EPHB2 22952896 2684863 Negative_regulation MAPK11 EPHB2 24340098 2895185 Negative_regulation MAPK11 EPHB2 25165721 198323 Negative_regulation MAPK11 EPHB2 25372283 3022985 Negative_regulation MAPK11 EPHB2 PMC3760629 1606152 Negative_regulation MAPK11 F2R 21378407 2175429 Negative_regulation MAPK11 FAS 21477291 527155 Negative_regulation MAPK11 MAP2K6 11034602 1517637 Negative_regulation MAPK11 MAP2K6 19852815 326779 Negative_regulation MAPK11 MAP2K6 20955562 120505 Negative_regulation MAPK11 MAP2K6 22413885 355193 Negative_regulation MAPK11 MAP2K6 22415879 721938 Negative_regulation MAPK11 MAP2K6 22870983 288850 Negative_regulation MAPK11 MAP2K6 23390495 2750744 Negative_regulation MAPK11 MAP2K6 24232636 2235870 Negative_regulation MAPK11 MAP2K6 24294133 3155406 Negative_regulation MAPK11 MAP2K6 24340098 2895191 Negative_regulation MAPK11 MAP2K6 24588908 1872376 Negative_regulation MAPK11 MAP2K6 25165721 198330 Negative_regulation MAPK11 MAP2K6 25200404 3145378 Negative_regulation MAPK11 MUC16 22977714 646601 Negative_regulation MAPK11 PTGER2 25327961 216535 Negative_regulation MAPK11 RASD1 24817889 1070779 Negative_regulation MAPK11 RCAN1 19124655 1553326 Negative_regulation MAPK11 RGS2 18067675 461931 Negative_regulation MAPK11 RGS2 24743392 2955288 Negative_regulation MAPK11 RGS2 24743392 2955289 Negative_regulation MAPK11 RGS2 24743392 2955433 Negative_regulation MAPK11 RGS2 24743392 2955462 Negative_regulation MAPK11 SARM1 24505321 2920586 Negative_regulation MAPK11 STK39 17988378 392929 Negative_regulation MAPK11 TLR7 22829768 3058238 Negative_regulation MAPK11 TNF 14613529 3095409 Negative_regulation MAPK11 TNF 15175101 523609 Negative_regulation MAPK11 TNF 21871121 1659614 Negative_regulation MAPK11 TNF 22675384 814612 Negative_regulation MAPK11 TNF 23784308 606086 Negative_regulation MAPK11 TNF 24304472 1482096 Negative_regulation MAPK11 TNF 24740309 2954641 Negative_regulation MAPK11 TNF 25364728 861727 Negative_regulation MAPK12 ARSA 24039842 2844913 Negative_regulation MAPK12 CCND1 19015320 1361443 Negative_regulation MAPK12 CD14 20011115 3045916 Negative_regulation MAPK12 CTGF 19852794 1227679 Negative_regulation MAPK12 CTGF 19852794 1227680 Negative_regulation MAPK12 EPHB2 19047466 1362069 Negative_regulation MAPK12 EPHB2 19821775 1236741 Negative_regulation MAPK12 EPHB2 20093365 1169070 Negative_regulation MAPK12 EPHB2 20526329 1924861 Negative_regulation MAPK12 EPHB2 20593014 2454320 Negative_regulation MAPK12 EPHB2 21120149 860386 Negative_regulation MAPK12 EPHB2 21162728 2232978 Negative_regulation MAPK12 EPHB2 21317295 717836 Negative_regulation MAPK12 EPHB2 21317295 717907 Negative_regulation MAPK12 EPHB2 21685889 1926363 Negative_regulation MAPK12 EPHB2 22367739 778331 Negative_regulation MAPK12 EPHB2 22413885 355195 Negative_regulation MAPK12 EPHB2 22447027 1956962 Negative_regulation MAPK12 EPHB2 22447027 1956963 Negative_regulation MAPK12 EPHB2 22567028 634414 Negative_regulation MAPK12 EPHB2 22675451 2648425 Negative_regulation MAPK12 EPHB2 22675451 2648489 Negative_regulation MAPK12 EPHB2 22723883 2654998 Negative_regulation MAPK12 EPHB2 22952896 2684864 Negative_regulation MAPK12 EPHB2 24340098 2895197 Negative_regulation MAPK12 EPHB2 25165721 198333 Negative_regulation MAPK12 EPHB2 25372283 3022986 Negative_regulation MAPK12 EPHB2 PMC3760629 1606155 Negative_regulation MAPK12 F2R 21378407 2175430 Negative_regulation MAPK12 FAS 21477291 527156 Negative_regulation MAPK12 MAP2K6 11034602 1517644 Negative_regulation MAPK12 MAP2K6 19852815 326786 Negative_regulation MAPK12 MAP2K6 20955562 120507 Negative_regulation MAPK12 MAP2K6 22413885 355202 Negative_regulation MAPK12 MAP2K6 22415879 721941 Negative_regulation MAPK12 MAP2K6 22870983 288851 Negative_regulation MAPK12 MAP2K6 23390495 2750751 Negative_regulation MAPK12 MAP2K6 24232636 2235871 Negative_regulation MAPK12 MAP2K6 24294133 3155414 Negative_regulation MAPK12 MAP2K6 24340098 2895203 Negative_regulation MAPK12 MAP2K6 24588908 1872383 Negative_regulation MAPK12 MAP2K6 25165721 198340 Negative_regulation MAPK12 MAP2K6 25200404 3145379 Negative_regulation MAPK12 MUC16 22977714 646602 Negative_regulation MAPK12 PTGER2 25327961 216536 Negative_regulation MAPK12 RASD1 24817889 1070780 Negative_regulation MAPK12 RCAN1 19124655 1553327 Negative_regulation MAPK12 RGS2 18067675 461932 Negative_regulation MAPK12 RGS2 24743392 2955292 Negative_regulation MAPK12 RGS2 24743392 2955293 Negative_regulation MAPK12 RGS2 24743392 2955435 Negative_regulation MAPK12 RGS2 24743392 2955464 Negative_regulation MAPK12 SARM1 24505321 2920587 Negative_regulation MAPK12 STK39 17988378 392944 Negative_regulation MAPK12 TLR7 22829768 3058248 Negative_regulation MAPK12 TNF 14613529 3095410 Negative_regulation MAPK12 TNF 15175101 523610 Negative_regulation MAPK12 TNF 21871121 1659615 Negative_regulation MAPK12 TNF 22675384 814614 Negative_regulation MAPK12 TNF 23784308 606087 Negative_regulation MAPK12 TNF 24304472 1482097 Negative_regulation MAPK12 TNF 24740309 2954642 Negative_regulation MAPK12 TNF 25364728 861728 Negative_regulation MAPK13 ARSA 24039842 2844915 Negative_regulation MAPK13 CCND1 19015320 1361446 Negative_regulation MAPK13 CD14 20011115 3045917 Negative_regulation MAPK13 CTGF 19852794 1227681 Negative_regulation MAPK13 CTGF 19852794 1227682 Negative_regulation MAPK13 EPHB2 19047466 1362070 Negative_regulation MAPK13 EPHB2 19821775 1236742 Negative_regulation MAPK13 EPHB2 20093365 1169075 Negative_regulation MAPK13 EPHB2 20526329 1924863 Negative_regulation MAPK13 EPHB2 20593014 2454321 Negative_regulation MAPK13 EPHB2 21120149 860387 Negative_regulation MAPK13 EPHB2 21162728 2232979 Negative_regulation MAPK13 EPHB2 21317295 717838 Negative_regulation MAPK13 EPHB2 21317295 717908 Negative_regulation MAPK13 EPHB2 21685889 1926364 Negative_regulation MAPK13 EPHB2 22367739 778332 Negative_regulation MAPK13 EPHB2 22413885 355204 Negative_regulation MAPK13 EPHB2 22447027 1956964 Negative_regulation MAPK13 EPHB2 22447027 1956965 Negative_regulation MAPK13 EPHB2 22567028 634415 Negative_regulation MAPK13 EPHB2 22675451 2648426 Negative_regulation MAPK13 EPHB2 22675451 2648490 Negative_regulation MAPK13 EPHB2 22723883 2654999 Negative_regulation MAPK13 EPHB2 22952896 2684865 Negative_regulation MAPK13 EPHB2 24340098 2895209 Negative_regulation MAPK13 EPHB2 25165721 198343 Negative_regulation MAPK13 EPHB2 25372283 3022987 Negative_regulation MAPK13 EPHB2 PMC3760629 1606158 Negative_regulation MAPK13 F2R 21378407 2175431 Negative_regulation MAPK13 FAS 21477291 527157 Negative_regulation MAPK13 MAP2K6 11034602 1517651 Negative_regulation MAPK13 MAP2K6 19852815 326793 Negative_regulation MAPK13 MAP2K6 20955562 120509 Negative_regulation MAPK13 MAP2K6 22413885 355211 Negative_regulation MAPK13 MAP2K6 22415879 721944 Negative_regulation MAPK13 MAP2K6 22870983 288852 Negative_regulation MAPK13 MAP2K6 23390495 2750758 Negative_regulation MAPK13 MAP2K6 24232636 2235872 Negative_regulation MAPK13 MAP2K6 24294133 3155422 Negative_regulation MAPK13 MAP2K6 24340098 2895215 Negative_regulation MAPK13 MAP2K6 24588908 1872390 Negative_regulation MAPK13 MAP2K6 25165721 198350 Negative_regulation MAPK13 MAP2K6 25200404 3145380 Negative_regulation MAPK13 MUC16 22977714 646603 Negative_regulation MAPK13 PTGER2 25327961 216537 Negative_regulation MAPK13 RASD1 24817889 1070781 Negative_regulation MAPK13 RCAN1 19124655 1553328 Negative_regulation MAPK13 RGS2 18067675 461933 Negative_regulation MAPK13 RGS2 24743392 2955296 Negative_regulation MAPK13 RGS2 24743392 2955297 Negative_regulation MAPK13 RGS2 24743392 2955437 Negative_regulation MAPK13 RGS2 24743392 2955466 Negative_regulation MAPK13 SARM1 24505321 2920588 Negative_regulation MAPK13 STK39 17988378 392959 Negative_regulation MAPK13 TLR7 22829768 3058258 Negative_regulation MAPK13 TNF 14613529 3095411 Negative_regulation MAPK13 TNF 15175101 523611 Negative_regulation MAPK13 TNF 21871121 1659616 Negative_regulation MAPK13 TNF 22675384 814616 Negative_regulation MAPK13 TNF 23784308 606088 Negative_regulation MAPK13 TNF 24304472 1482098 Negative_regulation MAPK13 TNF 24740309 2954643 Negative_regulation MAPK13 TNF 25364728 861729 Negative_regulation MAPK14 ARSA 24039842 2844917 Negative_regulation MAPK14 CCND1 19015320 1361449 Negative_regulation MAPK14 CD14 20011115 3045918 Negative_regulation MAPK14 CTGF 19852794 1227683 Negative_regulation MAPK14 CTGF 19852794 1227684 Negative_regulation MAPK14 EPHB2 19047466 1362071 Negative_regulation MAPK14 EPHB2 19821775 1236743 Negative_regulation MAPK14 EPHB2 20093365 1169080 Negative_regulation MAPK14 EPHB2 20526329 1924865 Negative_regulation MAPK14 EPHB2 20593014 2454322 Negative_regulation MAPK14 EPHB2 21120149 860388 Negative_regulation MAPK14 EPHB2 21162728 2232980 Negative_regulation MAPK14 EPHB2 21317295 717840 Negative_regulation MAPK14 EPHB2 21317295 717909 Negative_regulation MAPK14 EPHB2 21685889 1926365 Negative_regulation MAPK14 EPHB2 22367739 778333 Negative_regulation MAPK14 EPHB2 22413885 355213 Negative_regulation MAPK14 EPHB2 22447027 1956966 Negative_regulation MAPK14 EPHB2 22447027 1956967 Negative_regulation MAPK14 EPHB2 22567028 634416 Negative_regulation MAPK14 EPHB2 22675451 2648427 Negative_regulation MAPK14 EPHB2 22675451 2648491 Negative_regulation MAPK14 EPHB2 22723883 2655000 Negative_regulation MAPK14 EPHB2 22952896 2684866 Negative_regulation MAPK14 EPHB2 24340098 2895221 Negative_regulation MAPK14 EPHB2 25165721 198353 Negative_regulation MAPK14 EPHB2 25372283 3022988 Negative_regulation MAPK14 EPHB2 PMC3760629 1606161 Negative_regulation MAPK14 F2R 21378407 2175432 Negative_regulation MAPK14 FAS 21477291 527158 Negative_regulation MAPK14 MAP2K6 11034602 1517658 Negative_regulation MAPK14 MAP2K6 19852815 326800 Negative_regulation MAPK14 MAP2K6 20955562 120511 Negative_regulation MAPK14 MAP2K6 22413885 355220 Negative_regulation MAPK14 MAP2K6 22415879 721947 Negative_regulation MAPK14 MAP2K6 22870983 288853 Negative_regulation MAPK14 MAP2K6 23390495 2750765 Negative_regulation MAPK14 MAP2K6 24232636 2235873 Negative_regulation MAPK14 MAP2K6 24294133 3155430 Negative_regulation MAPK14 MAP2K6 24340098 2895227 Negative_regulation MAPK14 MAP2K6 24588908 1872397 Negative_regulation MAPK14 MAP2K6 25165721 198360 Negative_regulation MAPK14 MAP2K6 25200404 3145381 Negative_regulation MAPK14 MUC16 22977714 646604 Negative_regulation MAPK14 PTGER2 25327961 216538 Negative_regulation MAPK14 RASD1 24817889 1070782 Negative_regulation MAPK14 RCAN1 19124655 1553329 Negative_regulation MAPK14 RGS2 18067675 461934 Negative_regulation MAPK14 RGS2 24743392 2955300 Negative_regulation MAPK14 RGS2 24743392 2955301 Negative_regulation MAPK14 RGS2 24743392 2955439 Negative_regulation MAPK14 RGS2 24743392 2955468 Negative_regulation MAPK14 SARM1 24505321 2920589 Negative_regulation MAPK14 STK39 17988378 392974 Negative_regulation MAPK14 TLR7 22829768 3058268 Negative_regulation MAPK14 TNF 14613529 3095412 Negative_regulation MAPK14 TNF 15175101 523612 Negative_regulation MAPK14 TNF 21871121 1659617 Negative_regulation MAPK14 TNF 22675384 814618 Negative_regulation MAPK14 TNF 23784308 606089 Negative_regulation MAPK14 TNF 24304472 1482099 Negative_regulation MAPK14 TNF 24740309 2954644 Negative_regulation MAPK14 TNF 25364728 861730 Negative_regulation MAPK15 ARSA 24039842 2844904 Negative_regulation MAPK15 CCND1 19015320 1361426 Negative_regulation MAPK15 CD14 20011115 3045912 Negative_regulation MAPK15 CTGF 19852794 1227667 Negative_regulation MAPK15 CTGF 19852794 1227668 Negative_regulation MAPK15 EPHB2 19047466 1362065 Negative_regulation MAPK15 EPHB2 19821775 1236724 Negative_regulation MAPK15 EPHB2 20093365 1169045 Negative_regulation MAPK15 EPHB2 20526329 1924839 Negative_regulation MAPK15 EPHB2 20593014 2454303 Negative_regulation MAPK15 EPHB2 21120149 860369 Negative_regulation MAPK15 EPHB2 21162728 2232974 Negative_regulation MAPK15 EPHB2 21317295 717828 Negative_regulation MAPK15 EPHB2 21317295 717903 Negative_regulation MAPK15 EPHB2 21685889 1926359 Negative_regulation MAPK15 EPHB2 22367739 778314 Negative_regulation MAPK15 EPHB2 22413885 355151 Negative_regulation MAPK15 EPHB2 22447027 1956927 Negative_regulation MAPK15 EPHB2 22447027 1956928 Negative_regulation MAPK15 EPHB2 22567028 634391 Negative_regulation MAPK15 EPHB2 22675451 2648407 Negative_regulation MAPK15 EPHB2 22675451 2648485 Negative_regulation MAPK15 EPHB2 22723883 2654994 Negative_regulation MAPK15 EPHB2 22952896 2684860 Negative_regulation MAPK15 EPHB2 24340098 2895037 Negative_regulation MAPK15 EPHB2 25165721 198137 Negative_regulation MAPK15 EPHB2 25372283 3022969 Negative_regulation MAPK15 EPHB2 PMC3760629 1606115 Negative_regulation MAPK15 F2R 21378407 2175426 Negative_regulation MAPK15 FAS 21477291 527152 Negative_regulation MAPK15 MAP2K6 11034602 1517602 Negative_regulation MAPK15 MAP2K6 19852815 326660 Negative_regulation MAPK15 MAP2K6 20955562 120499 Negative_regulation MAPK15 MAP2K6 22413885 355158 Negative_regulation MAPK15 MAP2K6 22415879 721927 Negative_regulation MAPK15 MAP2K6 22870983 288846 Negative_regulation MAPK15 MAP2K6 23390495 2750723 Negative_regulation MAPK15 MAP2K6 24232636 2235866 Negative_regulation MAPK15 MAP2K6 24294133 3155291 Negative_regulation MAPK15 MAP2K6 24340098 2895043 Negative_regulation MAPK15 MAP2K6 24588908 1872355 Negative_regulation MAPK15 MAP2K6 25165721 198144 Negative_regulation MAPK15 MAP2K6 25200404 3145375 Negative_regulation MAPK15 MUC16 22977714 646598 Negative_regulation MAPK15 PTGER2 25327961 216530 Negative_regulation MAPK15 RASD1 24817889 1070776 Negative_regulation MAPK15 RCAN1 19124655 1553300 Negative_regulation MAPK15 RGS2 18067675 461928 Negative_regulation MAPK15 RGS2 24743392 2955270 Negative_regulation MAPK15 RGS2 24743392 2955271 Negative_regulation MAPK15 RGS2 24743392 2955425 Negative_regulation MAPK15 RGS2 24743392 2955454 Negative_regulation MAPK15 SARM1 24505321 2920583 Negative_regulation MAPK15 STK39 17988378 392869 Negative_regulation MAPK15 TLR7 22829768 3058208 Negative_regulation MAPK15 TNF 14613529 3095406 Negative_regulation MAPK15 TNF 15175101 523606 Negative_regulation MAPK15 TNF 21871121 1659611 Negative_regulation MAPK15 TNF 22675384 814590 Negative_regulation MAPK15 TNF 23784308 606083 Negative_regulation MAPK15 TNF 24304472 1482091 Negative_regulation MAPK15 TNF 24740309 2954638 Negative_regulation MAPK15 TNF 25364728 861724 Negative_regulation MAPK3 ANGPT1 17341311 279528 Negative_regulation MAPK3 ARSA 24039842 2844919 Negative_regulation MAPK3 CCND1 19015320 1361452 Negative_regulation MAPK3 CCND1 21887232 2548014 Negative_regulation MAPK3 CCND1 23187001 219782 Negative_regulation MAPK3 CCND1 24955027 680117 Negative_regulation MAPK3 CD14 19521507 3044167 Negative_regulation MAPK3 CD14 20011115 3045919 Negative_regulation MAPK3 CHI3L1 22211103 1058695 Negative_regulation MAPK3 CTGF 19852794 1227685 Negative_regulation MAPK3 CTGF 19852794 1227686 Negative_regulation MAPK3 CTGF 23259759 856343 Negative_regulation MAPK3 EFNB1 21795402 1793228 Negative_regulation MAPK3 EFNB1 24098442 2856369 Negative_regulation MAPK3 EPHB2 12769834 369117 Negative_regulation MAPK3 EPHB2 12925710 1296090 Negative_regulation MAPK3 EPHB2 19047466 1362072 Negative_regulation MAPK3 EPHB2 19821775 1236744 Negative_regulation MAPK3 EPHB2 20093365 1169085 Negative_regulation MAPK3 EPHB2 20526329 1924867 Negative_regulation MAPK3 EPHB2 20593014 2454323 Negative_regulation MAPK3 EPHB2 21120149 860389 Negative_regulation MAPK3 EPHB2 21162728 2232981 Negative_regulation MAPK3 EPHB2 21317295 717842 Negative_regulation MAPK3 EPHB2 21317295 717910 Negative_regulation MAPK3 EPHB2 21685889 1926366 Negative_regulation MAPK3 EPHB2 21795402 1793232 Negative_regulation MAPK3 EPHB2 22367739 778334 Negative_regulation MAPK3 EPHB2 22413885 355222 Negative_regulation MAPK3 EPHB2 22447027 1956968 Negative_regulation MAPK3 EPHB2 22447027 1956969 Negative_regulation MAPK3 EPHB2 22567028 634417 Negative_regulation MAPK3 EPHB2 22675451 2648428 Negative_regulation MAPK3 EPHB2 22675451 2648492 Negative_regulation MAPK3 EPHB2 22723883 2655001 Negative_regulation MAPK3 EPHB2 22952896 2684867 Negative_regulation MAPK3 EPHB2 23211542 2181817 Negative_regulation MAPK3 EPHB2 24066131 2851165 Negative_regulation MAPK3 EPHB2 24340098 2895233 Negative_regulation MAPK3 EPHB2 24748172 2956016 Negative_regulation MAPK3 EPHB2 25165721 198363 Negative_regulation MAPK3 EPHB2 25372283 3022989 Negative_regulation MAPK3 EPHB2 PMC3760629 1606164 Negative_regulation MAPK3 F2R 21378407 2175433 Negative_regulation MAPK3 FAS 21477291 527159 Negative_regulation MAPK3 GPR115 18777108 3090331 Negative_regulation MAPK3 GPR132 18777108 3090320 Negative_regulation MAPK3 GPR87 18777108 3090400 Negative_regulation MAPK3 HBEGF 22984591 2689346 Negative_regulation MAPK3 MAP2K6 10769026 1257128 Negative_regulation MAPK3 MAP2K6 11034602 1517665 Negative_regulation MAPK3 MAP2K6 12775357 1738583 Negative_regulation MAPK3 MAP2K6 15123736 1308394 Negative_regulation MAPK3 MAP2K6 16103225 1323162 Negative_regulation MAPK3 MAP2K6 19575782 283096 Negative_regulation MAPK3 MAP2K6 19619605 833439 Negative_regulation MAPK3 MAP2K6 19852815 326807 Negative_regulation MAPK3 MAP2K6 20955562 120513 Negative_regulation MAPK3 MAP2K6 22413885 355229 Negative_regulation MAPK3 MAP2K6 22415879 721950 Negative_regulation MAPK3 MAP2K6 22870983 288854 Negative_regulation MAPK3 MAP2K6 23311607 482729 Negative_regulation MAPK3 MAP2K6 23390495 2750772 Negative_regulation MAPK3 MAP2K6 23734197 2799591 Negative_regulation MAPK3 MAP2K6 24232636 2235874 Negative_regulation MAPK3 MAP2K6 24294133 3155439 Negative_regulation MAPK3 MAP2K6 24340098 2895239 Negative_regulation MAPK3 MAP2K6 24566153 1124286 Negative_regulation MAPK3 MAP2K6 24588908 1872404 Negative_regulation MAPK3 MAP2K6 25165721 198370 Negative_regulation MAPK3 MAP2K6 25200404 3145382 Negative_regulation MAPK3 MAP2K6 25330306 3017445 Negative_regulation MAPK3 MUC16 22977714 646605 Negative_regulation MAPK3 PLAU 19503095 2125545 Negative_regulation MAPK3 PTGER2 25327961 216539 Negative_regulation MAPK3 RASD1 24817889 1070783 Negative_regulation MAPK3 RCAN1 19124655 1553330 Negative_regulation MAPK3 RGS2 18067675 461935 Negative_regulation MAPK3 RGS2 24743392 2955304 Negative_regulation MAPK3 RGS2 24743392 2955305 Negative_regulation MAPK3 RGS2 24743392 2955402 Negative_regulation MAPK3 RGS2 24743392 2955441 Negative_regulation MAPK3 RGS2 24743392 2955470 Negative_regulation MAPK3 SARM1 24505321 2920590 Negative_regulation MAPK3 SPHK1 16636149 1329321 Negative_regulation MAPK3 SPHK1 16636149 1329361 Negative_regulation MAPK3 SPHK1 20634980 2455777 Negative_regulation MAPK3 SPHK1 21936950 1697758 Negative_regulation MAPK3 STK39 17988378 392989 Negative_regulation MAPK3 TLR7 22091401 1831066 Negative_regulation MAPK3 TLR7 22829768 3058278 Negative_regulation MAPK3 TNF 14613529 3095413 Negative_regulation MAPK3 TNF 15175101 523613 Negative_regulation MAPK3 TNF 18591389 706348 Negative_regulation MAPK3 TNF 18822184 3212648 Negative_regulation MAPK3 TNF 18822184 3212649 Negative_regulation MAPK3 TNF 18822184 3212650 Negative_regulation MAPK3 TNF 18822184 3212652 Negative_regulation MAPK3 TNF 18822184 3212653 Negative_regulation MAPK3 TNF 18822184 3212655 Negative_regulation MAPK3 TNF 19808894 711192 Negative_regulation MAPK3 TNF 19808894 711193 Negative_regulation MAPK3 TNF 19808894 711436 Negative_regulation MAPK3 TNF 20827314 979314 Negative_regulation MAPK3 TNF 21871121 1659618 Negative_regulation MAPK3 TNF 22675384 814620 Negative_regulation MAPK3 TNF 22919361 3153801 Negative_regulation MAPK3 TNF 23784308 606090 Negative_regulation MAPK3 TNF 24215724 538187 Negative_regulation MAPK3 TNF 24304472 1482100 Negative_regulation MAPK3 TNF 24304472 1482130 Negative_regulation MAPK3 TNF 24624056 938727 Negative_regulation MAPK3 TNF 24740309 2954645 Negative_regulation MAPK3 TNF 25364728 861731 Negative_regulation MAPK3 TNFSF10 23773282 483488 Negative_regulation MAPK4 ARSA 24039842 2844921 Negative_regulation MAPK4 CCND1 19015320 1361455 Negative_regulation MAPK4 CD14 20011115 3045920 Negative_regulation MAPK4 CTGF 19852794 1227687 Negative_regulation MAPK4 CTGF 19852794 1227688 Negative_regulation MAPK4 EPHB2 19047466 1362073 Negative_regulation MAPK4 EPHB2 19821775 1236745 Negative_regulation MAPK4 EPHB2 20093365 1169090 Negative_regulation MAPK4 EPHB2 20526329 1924869 Negative_regulation MAPK4 EPHB2 20593014 2454324 Negative_regulation MAPK4 EPHB2 21120149 860390 Negative_regulation MAPK4 EPHB2 21162728 2232982 Negative_regulation MAPK4 EPHB2 21317295 717844 Negative_regulation MAPK4 EPHB2 21317295 717911 Negative_regulation MAPK4 EPHB2 21685889 1926367 Negative_regulation MAPK4 EPHB2 22367739 778335 Negative_regulation MAPK4 EPHB2 22413885 355231 Negative_regulation MAPK4 EPHB2 22447027 1956970 Negative_regulation MAPK4 EPHB2 22447027 1956971 Negative_regulation MAPK4 EPHB2 22567028 634418 Negative_regulation MAPK4 EPHB2 22675451 2648429 Negative_regulation MAPK4 EPHB2 22675451 2648493 Negative_regulation MAPK4 EPHB2 22723883 2655002 Negative_regulation MAPK4 EPHB2 22952896 2684868 Negative_regulation MAPK4 EPHB2 24340098 2895245 Negative_regulation MAPK4 EPHB2 25165721 198373 Negative_regulation MAPK4 EPHB2 25372283 3022990 Negative_regulation MAPK4 EPHB2 PMC3760629 1606167 Negative_regulation MAPK4 F2R 21378407 2175434 Negative_regulation MAPK4 FAS 21477291 527160 Negative_regulation MAPK4 MAP2K6 11034602 1517672 Negative_regulation MAPK4 MAP2K6 19852815 326814 Negative_regulation MAPK4 MAP2K6 20955562 120515 Negative_regulation MAPK4 MAP2K6 22413885 355238 Negative_regulation MAPK4 MAP2K6 22415879 721953 Negative_regulation MAPK4 MAP2K6 22870983 288855 Negative_regulation MAPK4 MAP2K6 23390495 2750779 Negative_regulation MAPK4 MAP2K6 24232636 2235875 Negative_regulation MAPK4 MAP2K6 24294133 3155458 Negative_regulation MAPK4 MAP2K6 24340098 2895251 Negative_regulation MAPK4 MAP2K6 24588908 1872411 Negative_regulation MAPK4 MAP2K6 25165721 198380 Negative_regulation MAPK4 MAP2K6 25200404 3145383 Negative_regulation MAPK4 MUC16 22977714 646606 Negative_regulation MAPK4 PTGER2 25327961 216540 Negative_regulation MAPK4 RASD1 24817889 1070784 Negative_regulation MAPK4 RCAN1 19124655 1553331 Negative_regulation MAPK4 RGS2 18067675 461936 Negative_regulation MAPK4 RGS2 24743392 2955308 Negative_regulation MAPK4 RGS2 24743392 2955309 Negative_regulation MAPK4 RGS2 24743392 2955443 Negative_regulation MAPK4 RGS2 24743392 2955472 Negative_regulation MAPK4 SARM1 24505321 2920591 Negative_regulation MAPK4 STK39 17988378 393004 Negative_regulation MAPK4 TLR7 22829768 3058288 Negative_regulation MAPK4 TNF 14613529 3095414 Negative_regulation MAPK4 TNF 15175101 523614 Negative_regulation MAPK4 TNF 21871121 1659619 Negative_regulation MAPK4 TNF 22675384 814622 Negative_regulation MAPK4 TNF 23784308 606091 Negative_regulation MAPK4 TNF 24304472 1482101 Negative_regulation MAPK4 TNF 24740309 2954646 Negative_regulation MAPK4 TNF 25364728 861732 Negative_regulation MAPK6 ARSA 24039842 2844923 Negative_regulation MAPK6 CCND1 19015320 1361458 Negative_regulation MAPK6 CD14 20011115 3045921 Negative_regulation MAPK6 CTGF 19852794 1227689 Negative_regulation MAPK6 CTGF 19852794 1227690 Negative_regulation MAPK6 EPHB2 19047466 1362074 Negative_regulation MAPK6 EPHB2 19821775 1236746 Negative_regulation MAPK6 EPHB2 20093365 1169095 Negative_regulation MAPK6 EPHB2 20526329 1924871 Negative_regulation MAPK6 EPHB2 20593014 2454325 Negative_regulation MAPK6 EPHB2 21120149 860391 Negative_regulation MAPK6 EPHB2 21162728 2232983 Negative_regulation MAPK6 EPHB2 21317295 717846 Negative_regulation MAPK6 EPHB2 21317295 717912 Negative_regulation MAPK6 EPHB2 21685889 1926368 Negative_regulation MAPK6 EPHB2 22367739 778336 Negative_regulation MAPK6 EPHB2 22413885 355240 Negative_regulation MAPK6 EPHB2 22447027 1956972 Negative_regulation MAPK6 EPHB2 22447027 1956973 Negative_regulation MAPK6 EPHB2 22567028 634419 Negative_regulation MAPK6 EPHB2 22675451 2648430 Negative_regulation MAPK6 EPHB2 22675451 2648494 Negative_regulation MAPK6 EPHB2 22723883 2655003 Negative_regulation MAPK6 EPHB2 22952896 2684869 Negative_regulation MAPK6 EPHB2 24340098 2895257 Negative_regulation MAPK6 EPHB2 25165721 198383 Negative_regulation MAPK6 EPHB2 25372283 3022991 Negative_regulation MAPK6 EPHB2 PMC3760629 1606170 Negative_regulation MAPK6 F2R 21378407 2175435 Negative_regulation MAPK6 FAS 21477291 527161 Negative_regulation MAPK6 MAP2K6 11034602 1517679 Negative_regulation MAPK6 MAP2K6 19852815 326821 Negative_regulation MAPK6 MAP2K6 20955562 120517 Negative_regulation MAPK6 MAP2K6 22413885 355247 Negative_regulation MAPK6 MAP2K6 22415879 721956 Negative_regulation MAPK6 MAP2K6 22870983 288856 Negative_regulation MAPK6 MAP2K6 23390495 2750786 Negative_regulation MAPK6 MAP2K6 24232636 2235876 Negative_regulation MAPK6 MAP2K6 24294133 3155466 Negative_regulation MAPK6 MAP2K6 24340098 2895263 Negative_regulation MAPK6 MAP2K6 24588908 1872418 Negative_regulation MAPK6 MAP2K6 25165721 198390 Negative_regulation MAPK6 MAP2K6 25200404 3145384 Negative_regulation MAPK6 MUC16 22977714 646607 Negative_regulation MAPK6 PTGER2 25327961 216541 Negative_regulation MAPK6 RASD1 24817889 1070785 Negative_regulation MAPK6 RCAN1 19124655 1553332 Negative_regulation MAPK6 RGS2 18067675 461937 Negative_regulation MAPK6 RGS2 24743392 2955312 Negative_regulation MAPK6 RGS2 24743392 2955313 Negative_regulation MAPK6 RGS2 24743392 2955445 Negative_regulation MAPK6 RGS2 24743392 2955474 Negative_regulation MAPK6 SARM1 24505321 2920592 Negative_regulation MAPK6 STK39 17988378 393019 Negative_regulation MAPK6 TLR7 22829768 3058298 Negative_regulation MAPK6 TNF 14613529 3095415 Negative_regulation MAPK6 TNF 15175101 523615 Negative_regulation MAPK6 TNF 21871121 1659620 Negative_regulation MAPK6 TNF 22675384 814624 Negative_regulation MAPK6 TNF 23784308 606092 Negative_regulation MAPK6 TNF 24304472 1482102 Negative_regulation MAPK6 TNF 24740309 2954647 Negative_regulation MAPK6 TNF 25364728 861733 Negative_regulation MAPK7 ARSA 24039842 2844925 Negative_regulation MAPK7 CCND1 19015320 1361461 Negative_regulation MAPK7 CD14 20011115 3045922 Negative_regulation MAPK7 CTGF 19852794 1227691 Negative_regulation MAPK7 CTGF 19852794 1227692 Negative_regulation MAPK7 EPHB2 19047466 1362075 Negative_regulation MAPK7 EPHB2 19821775 1236747 Negative_regulation MAPK7 EPHB2 20093365 1169100 Negative_regulation MAPK7 EPHB2 20526329 1924873 Negative_regulation MAPK7 EPHB2 20593014 2454326 Negative_regulation MAPK7 EPHB2 21120149 860392 Negative_regulation MAPK7 EPHB2 21162728 2232984 Negative_regulation MAPK7 EPHB2 21317295 717848 Negative_regulation MAPK7 EPHB2 21317295 717913 Negative_regulation MAPK7 EPHB2 21685889 1926369 Negative_regulation MAPK7 EPHB2 22367739 778337 Negative_regulation MAPK7 EPHB2 22413885 355249 Negative_regulation MAPK7 EPHB2 22447027 1956974 Negative_regulation MAPK7 EPHB2 22447027 1956975 Negative_regulation MAPK7 EPHB2 22567028 634420 Negative_regulation MAPK7 EPHB2 22675451 2648431 Negative_regulation MAPK7 EPHB2 22675451 2648495 Negative_regulation MAPK7 EPHB2 22723883 2655004 Negative_regulation MAPK7 EPHB2 22952896 2684870 Negative_regulation MAPK7 EPHB2 24340098 2895269 Negative_regulation MAPK7 EPHB2 25165721 198393 Negative_regulation MAPK7 EPHB2 25372283 3022992 Negative_regulation MAPK7 EPHB2 PMC3760629 1606173 Negative_regulation MAPK7 F2R 21378407 2175436 Negative_regulation MAPK7 FAS 21477291 527162 Negative_regulation MAPK7 MAP2K6 11034602 1517686 Negative_regulation MAPK7 MAP2K6 19852815 326828 Negative_regulation MAPK7 MAP2K6 20955562 120519 Negative_regulation MAPK7 MAP2K6 22413885 355256 Negative_regulation MAPK7 MAP2K6 22415879 721959 Negative_regulation MAPK7 MAP2K6 22870983 288857 Negative_regulation MAPK7 MAP2K6 23390495 2750793 Negative_regulation MAPK7 MAP2K6 24232636 2235877 Negative_regulation MAPK7 MAP2K6 24294133 3155474 Negative_regulation MAPK7 MAP2K6 24340098 2895275 Negative_regulation MAPK7 MAP2K6 24588908 1872425 Negative_regulation MAPK7 MAP2K6 25165721 198400 Negative_regulation MAPK7 MAP2K6 25200404 3145385 Negative_regulation MAPK7 MUC16 22977714 646608 Negative_regulation MAPK7 PTGER2 25327961 216542 Negative_regulation MAPK7 RASD1 24817889 1070786 Negative_regulation MAPK7 RCAN1 19124655 1553333 Negative_regulation MAPK7 RGS2 18067675 461938 Negative_regulation MAPK7 RGS2 24743392 2955316 Negative_regulation MAPK7 RGS2 24743392 2955317 Negative_regulation MAPK7 RGS2 24743392 2955447 Negative_regulation MAPK7 RGS2 24743392 2955476 Negative_regulation MAPK7 SARM1 24505321 2920593 Negative_regulation MAPK7 STK39 17988378 393034 Negative_regulation MAPK7 TLR7 22829768 3058308 Negative_regulation MAPK7 TNF 14613529 3095416 Negative_regulation MAPK7 TNF 15175101 523616 Negative_regulation MAPK7 TNF 21871121 1659621 Negative_regulation MAPK7 TNF 22675384 814626 Negative_regulation MAPK7 TNF 23784308 606093 Negative_regulation MAPK7 TNF 24304472 1482103 Negative_regulation MAPK7 TNF 24740309 2954648 Negative_regulation MAPK7 TNF 25364728 861734 Negative_regulation MAPK7 WNT7A 24204697 2873399 Negative_regulation MAPK7 WNT7A 24204697 2873491 Negative_regulation MAPK8 ARSA 24039842 2844927 Negative_regulation MAPK8 CCND1 19015320 1361464 Negative_regulation MAPK8 CD14 20011115 3045923 Negative_regulation MAPK8 CTGF 19852794 1227693 Negative_regulation MAPK8 CTGF 19852794 1227694 Negative_regulation MAPK8 EPHB2 19047466 1362076 Negative_regulation MAPK8 EPHB2 19821775 1236748 Negative_regulation MAPK8 EPHB2 20093365 1169105 Negative_regulation MAPK8 EPHB2 20526329 1924875 Negative_regulation MAPK8 EPHB2 20593014 2454327 Negative_regulation MAPK8 EPHB2 21120149 860393 Negative_regulation MAPK8 EPHB2 21162728 2232985 Negative_regulation MAPK8 EPHB2 21317295 717850 Negative_regulation MAPK8 EPHB2 21317295 717914 Negative_regulation MAPK8 EPHB2 21685889 1926370 Negative_regulation MAPK8 EPHB2 22367739 778338 Negative_regulation MAPK8 EPHB2 22413885 355258 Negative_regulation MAPK8 EPHB2 22447027 1956976 Negative_regulation MAPK8 EPHB2 22447027 1956977 Negative_regulation MAPK8 EPHB2 22567028 634421 Negative_regulation MAPK8 EPHB2 22675451 2648432 Negative_regulation MAPK8 EPHB2 22675451 2648496 Negative_regulation MAPK8 EPHB2 22723883 2655005 Negative_regulation MAPK8 EPHB2 22952896 2684871 Negative_regulation MAPK8 EPHB2 24340098 2895281 Negative_regulation MAPK8 EPHB2 25165721 198403 Negative_regulation MAPK8 EPHB2 25372283 3022993 Negative_regulation MAPK8 EPHB2 PMC3760629 1606176 Negative_regulation MAPK8 F2R 21378407 2175437 Negative_regulation MAPK8 FAS 21477291 527163 Negative_regulation MAPK8 MAP2K6 11034602 1517693 Negative_regulation MAPK8 MAP2K6 19852815 326835 Negative_regulation MAPK8 MAP2K6 20955562 120521 Negative_regulation MAPK8 MAP2K6 22413885 355265 Negative_regulation MAPK8 MAP2K6 22415879 721962 Negative_regulation MAPK8 MAP2K6 22870983 288858 Negative_regulation MAPK8 MAP2K6 23390495 2750800 Negative_regulation MAPK8 MAP2K6 24232636 2235878 Negative_regulation MAPK8 MAP2K6 24294133 3155482 Negative_regulation MAPK8 MAP2K6 24340098 2895287 Negative_regulation MAPK8 MAP2K6 24588908 1872432 Negative_regulation MAPK8 MAP2K6 25165721 198410 Negative_regulation MAPK8 MAP2K6 25200404 3145386 Negative_regulation MAPK8 MUC16 22977714 646609 Negative_regulation MAPK8 NGFR 24632812 2934257 Negative_regulation MAPK8 PTGER2 25327961 216543 Negative_regulation MAPK8 RASD1 24817889 1070787 Negative_regulation MAPK8 RCAN1 19124655 1553334 Negative_regulation MAPK8 RGS2 18067675 461939 Negative_regulation MAPK8 RGS2 24743392 2955320 Negative_regulation MAPK8 RGS2 24743392 2955321 Negative_regulation MAPK8 RGS2 24743392 2955449 Negative_regulation MAPK8 RGS2 24743392 2955478 Negative_regulation MAPK8 SARM1 24505321 2920594 Negative_regulation MAPK8 STK39 17988378 393049 Negative_regulation MAPK8 TLR7 22829768 3058318 Negative_regulation MAPK8 TNF 14613529 3095417 Negative_regulation MAPK8 TNF 15175101 523617 Negative_regulation MAPK8 TNF 21871121 1659622 Negative_regulation MAPK8 TNF 22675384 814628 Negative_regulation MAPK8 TNF 23784308 606094 Negative_regulation MAPK8 TNF 24304472 1482104 Negative_regulation MAPK8 TNF 24740309 2954649 Negative_regulation MAPK8 TNF 25364728 861735 Negative_regulation MAPK8IP1 TNFSF10 21237154 828992 Negative_regulation MAPK9 ARSA 24039842 2844929 Negative_regulation MAPK9 CCND1 19015320 1361467 Negative_regulation MAPK9 CD14 20011115 3045924 Negative_regulation MAPK9 CTGF 19852794 1227695 Negative_regulation MAPK9 CTGF 19852794 1227696 Negative_regulation MAPK9 EPHB2 19047466 1362077 Negative_regulation MAPK9 EPHB2 19821775 1236749 Negative_regulation MAPK9 EPHB2 20093365 1169110 Negative_regulation MAPK9 EPHB2 20526329 1924877 Negative_regulation MAPK9 EPHB2 20593014 2454328 Negative_regulation MAPK9 EPHB2 21120149 860394 Negative_regulation MAPK9 EPHB2 21162728 2232986 Negative_regulation MAPK9 EPHB2 21317295 717852 Negative_regulation MAPK9 EPHB2 21317295 717915 Negative_regulation MAPK9 EPHB2 21685889 1926371 Negative_regulation MAPK9 EPHB2 22367739 778339 Negative_regulation MAPK9 EPHB2 22413885 355267 Negative_regulation MAPK9 EPHB2 22447027 1956978 Negative_regulation MAPK9 EPHB2 22447027 1956979 Negative_regulation MAPK9 EPHB2 22567028 634422 Negative_regulation MAPK9 EPHB2 22675451 2648433 Negative_regulation MAPK9 EPHB2 22675451 2648497 Negative_regulation MAPK9 EPHB2 22723883 2655006 Negative_regulation MAPK9 EPHB2 22952896 2684872 Negative_regulation MAPK9 EPHB2 23472073 2763835 Negative_regulation MAPK9 EPHB2 24340098 2895293 Negative_regulation MAPK9 EPHB2 25165721 198413 Negative_regulation MAPK9 EPHB2 25372283 3022994 Negative_regulation MAPK9 EPHB2 PMC3760629 1606179 Negative_regulation MAPK9 F2R 21378407 2175438 Negative_regulation MAPK9 FAS 21477291 527164 Negative_regulation MAPK9 MAP2K6 11034602 1517700 Negative_regulation MAPK9 MAP2K6 19852815 326842 Negative_regulation MAPK9 MAP2K6 20955562 120523 Negative_regulation MAPK9 MAP2K6 22413885 355274 Negative_regulation MAPK9 MAP2K6 22415879 721965 Negative_regulation MAPK9 MAP2K6 22870983 288859 Negative_regulation MAPK9 MAP2K6 23390495 2750807 Negative_regulation MAPK9 MAP2K6 24232636 2235879 Negative_regulation MAPK9 MAP2K6 24294133 3155490 Negative_regulation MAPK9 MAP2K6 24340098 2895299 Negative_regulation MAPK9 MAP2K6 24588908 1872439 Negative_regulation MAPK9 MAP2K6 25165721 198420 Negative_regulation MAPK9 MAP2K6 25200404 3145387 Negative_regulation MAPK9 MUC16 22977714 646610 Negative_regulation MAPK9 PTGER2 25327961 216544 Negative_regulation MAPK9 RASD1 24817889 1070788 Negative_regulation MAPK9 RCAN1 19124655 1553335 Negative_regulation MAPK9 RGS2 18067675 461940 Negative_regulation MAPK9 RGS2 24743392 2955324 Negative_regulation MAPK9 RGS2 24743392 2955325 Negative_regulation MAPK9 RGS2 24743392 2955451 Negative_regulation MAPK9 RGS2 24743392 2955480 Negative_regulation MAPK9 SARM1 24505321 2920595 Negative_regulation MAPK9 STK39 17988378 393064 Negative_regulation MAPK9 TLR7 22829768 3058328 Negative_regulation MAPK9 TNF 14613529 3095418 Negative_regulation MAPK9 TNF 15175101 523618 Negative_regulation MAPK9 TNF 21871121 1659623 Negative_regulation MAPK9 TNF 22675384 814630 Negative_regulation MAPK9 TNF 23784308 606095 Negative_regulation MAPK9 TNF 24304472 1482105 Negative_regulation MAPK9 TNF 24740309 2954650 Negative_regulation MAPK9 TNF 25364728 861736 Negative_regulation MAPKAP1 EPHB2 24212825 498956 Negative_regulation MAPKAP1 MAP2K6 24212825 498962 Negative_regulation MAPKAP1 TCN1 20489726 546882 Negative_regulation MAPKAPK2 EPHB2 24917786 932015 Negative_regulation MAPKAPK2 MAP2K6 24917786 932021 Negative_regulation MAPKAPK2 SPHK1 24917786 932013 Negative_regulation MARCH1 TLR7 21220452 1562340 Negative_regulation MARK1 EPHB2 20855497 1560238 Negative_regulation MARK2 EPHB2 20855497 1560229 Negative_regulation MARK3 EPHB2 20855497 1560240 Negative_regulation MARK4 EPHB2 20855497 1560225 Negative_regulation MAST1 TNF 25062998 1620028 Negative_regulation MAST2 TNF 25062998 1620031 Negative_regulation MAST3 TNF 25062998 1620034 Negative_regulation MAST4 TNF 25062998 1620037 Negative_regulation MATK EPHB2 21772273 1933164 Negative_regulation MBP IFI27 19665013 698146 Negative_regulation MBTPS1 SPHK1 20577214 1985416 Negative_regulation MBTPS1 SPHK1 20634980 2455715 Negative_regulation MBTPS1 SPHK1 24970177 208774 Negative_regulation MBTPS1 SPHK1 25109605 2171864 Negative_regulation MCL1 EPHB2 22751450 1720726 Negative_regulation MCL1 EPHB2 22751450 1720739 Negative_regulation MCL1 TNFSF10 21513580 1861963 Negative_regulation MCL1 TNFSF10 23773282 483489 Negative_regulation MCL1 TNFSF10 24434509 570874 Negative_regulation MDM2 EPHB2 23342042 2741731 Negative_regulation ME1 FAS 23208508 2150891 Negative_regulation MED1 EPHB2 21789185 2538065 Negative_regulation MED1 MAP2K6 21242991 1900854 Negative_regulation MED1 TNF 23670971 727350 Negative_regulation MED10 EPHB2 21789185 2538060 Negative_regulation MED10 TNF 23670971 727345 Negative_regulation MED11 EPHB2 21789185 2538063 Negative_regulation MED11 TNF 23670971 727348 Negative_regulation MED12 MAP2K6 21242991 1900763 Negative_regulation MED13 EPHB2 21789185 2538047 Negative_regulation MED13 MAP2K6 21242991 1900798 Negative_regulation MED13 TNF 23670971 727332 Negative_regulation MED13L EPHB2 21789185 2538048 Negative_regulation MED13L TNF 23670971 727333 Negative_regulation MED14 EPHB2 21789185 2538052 Negative_regulation MED14 MAP2K6 21242991 1900812 Negative_regulation MED14 TNF 23670971 727337 Negative_regulation MED15 EPHB2 21789185 2538041 Negative_regulation MED15 MAP2K6 21242991 1900770 Negative_regulation MED15 TNF 23670971 727326 Negative_regulation MED16 EPHB2 21789185 2538043 Negative_regulation MED16 TNF 23670971 727328 Negative_regulation MED17 EPHB2 21789185 2538054 Negative_regulation MED17 MAP2K6 21242991 1900826 Negative_regulation MED17 TNF 23670971 727339 Negative_regulation MED18 EPHB2 21789185 2538059 Negative_regulation MED18 TNF 23670971 727344 Negative_regulation MED19 EPHB2 21789185 2538062 Negative_regulation MED19 TNF 23670971 727347 Negative_regulation MED20 EPHB2 21789185 2538042 Negative_regulation MED20 TNF 23670971 727327 Negative_regulation MED21 EPHB2 21789185 2538039 Negative_regulation MED21 MAP2K6 21242991 1900756 Negative_regulation MED21 TNF 23670971 727324 Negative_regulation MED22 EPHB2 21789185 2538040 Negative_regulation MED22 TNF 23670971 727325 Negative_regulation MED23 EPHB2 21789185 2538053 Negative_regulation MED23 MAP2K6 21242991 1900819 Negative_regulation MED23 TNF 23670971 727338 Negative_regulation MED24 EPHB2 21789185 2538049 Negative_regulation MED24 MAP2K6 21242991 1900805 Negative_regulation MED24 TNF 23670971 727334 Negative_regulation MED25 EPHB2 21789185 2538061 Negative_regulation MED25 MAP2K6 21242991 1900847 Negative_regulation MED25 TNF 23670971 727346 Negative_regulation MED26 EPHB2 21789185 2538055 Negative_regulation MED26 MAP2K6 21242991 1900833 Negative_regulation MED26 TNF 23670971 727340 Negative_regulation MED27 EPHB2 21789185 2538056 Negative_regulation MED27 TNF 23670971 727341 Negative_regulation MED29 EPHB2 21789185 2538051 Negative_regulation MED29 TNF 23670971 727336 Negative_regulation MED30 EPHB2 21789185 2538050 Negative_regulation MED30 TNF 23670971 727335 Negative_regulation MED31 EPHB2 21789185 2538058 Negative_regulation MED31 TNF 23670971 727343 Negative_regulation MED4 EPHB2 21789185 2538044 Negative_regulation MED4 TNF 23670971 727329 Negative_regulation MED6 EPHB2 21789185 2538045 Negative_regulation MED6 MAP2K6 21242991 1900791 Negative_regulation MED6 TNF 23670971 727330 Negative_regulation MED7 EPHB2 21789185 2538057 Negative_regulation MED7 MAP2K6 21242991 1900840 Negative_regulation MED7 TNF 23670971 727342 Negative_regulation MED8 EPHB2 21789185 2538046 Negative_regulation MED8 TNF 23670971 727331 Negative_regulation MEF2C TNF 20967264 2478595 Negative_regulation MET CEACAM6 25398131 3027596 Negative_regulation MET EPHB2 23826330 2812060 Negative_regulation MET EPHB2 24287743 502489 Negative_regulation MET EPHB2 25057499 195511 Negative_regulation MET FAS PMC2243071 1475584 Negative_regulation MET TNF 25332857 3165774 Negative_regulation MFGE8 TLR7 19534815 1696313 Negative_regulation MFN2 TNF 24898700 1483516 Negative_regulation MGMT MMP7 23300791 2735965 Negative_regulation MGMT MMP7 23300791 2735966 Negative_regulation MGMT MMP7 23300791 2735977 Negative_regulation MGMT MMP7 23300791 2735978 Negative_regulation MIC12 HBEGF 21754948 812599 Negative_regulation MIC7 HBEGF 21754948 812600 Negative_regulation MIF TNF 11094508 658208 Negative_regulation MIP AIF1 21479220 2511192 Negative_regulation MIP AKT1 24009857 203917 Negative_regulation MIP AKT1 24009857 203926 Negative_regulation MIP AKT2 24009857 203918 Negative_regulation MIP AKT2 24009857 203927 Negative_regulation MIP AKT3 24009857 203919 Negative_regulation MIP AKT3 24009857 203928 Negative_regulation MIP APOA1 20846396 353592 Negative_regulation MIP APOE 20846396 353593 Negative_regulation MIP CD40 21592361 3119658 Negative_regulation MIP CD40 21592361 3119666 Negative_regulation MIP CFTR 21301926 1050345 Negative_regulation MIP CFTR 21301926 1050354 Negative_regulation MIP CFTR 24671173 2946580 Negative_regulation MIP CFTR 24671173 2946586 Negative_regulation MIP CRYGEP 24421998 1675319 Negative_regulation MIP CTSD 20614007 2454675 Negative_regulation MIP CYR61 24517278 131748 Negative_regulation MIP CYR61 24517278 131864 Negative_regulation MIP DST 22792369 2663515 Negative_regulation MIP ETS1 22294049 1918685 Negative_regulation MIP FOXE3 25347445 3019827 Negative_regulation MIP GJC1 17262012 1906252 Negative_regulation MIP HDAC3 23063365 608655 Negative_regulation MIP IFIT2 19108715 352533 Negative_regulation MIP IL10 21777484 3091282 Negative_regulation MIP IL10 21777484 3091288 Negative_regulation MIP IL10 22566778 3152676 Negative_regulation MIP IL10 23272193 2730122 Negative_regulation MIP IL12A 18809712 1552097 Negative_regulation MIP IL12B 18809712 1552098 Negative_regulation MIP IL18 18809712 1552099 Negative_regulation MIP IL1A 17145956 1543559 Negative_regulation MIP IL4 21777484 3091283 Negative_regulation MIP IL4 21777484 3091289 Negative_regulation MIP IL4 21777484 3091290 Negative_regulation MIP INS 20200310 729504 Negative_regulation MIP LBP 20846396 353606 Negative_regulation MIP LPL 3279154 1580741 Negative_regulation MIP MAPK1 19781090 1625764 Negative_regulation MIP MAPK10 19781090 1625765 Negative_regulation MIP MAPK11 19781090 1625766 Negative_regulation MIP MAPK12 19781090 1625767 Negative_regulation MIP MAPK13 19781090 1625768 Negative_regulation MIP MAPK14 19781090 1625769 Negative_regulation MIP MAPK15 19781090 1625763 Negative_regulation MIP MAPK3 19781090 1625770 Negative_regulation MIP MAPK4 19781090 1625771 Negative_regulation MIP MAPK6 19781090 1625772 Negative_regulation MIP MAPK7 19781090 1625773 Negative_regulation MIP MAPK8 19781090 1625774 Negative_regulation MIP MAPK9 19781090 1625775 Negative_regulation MIP MIPEP 24421998 1675320 Negative_regulation MIP PDLIM7 21592361 3119659 Negative_regulation MIP PDLIM7 21592361 3119667 Negative_regulation MIP PIK3CA 17101049 106759 Negative_regulation MIP PIK3CA 24009857 203929 Negative_regulation MIP PIK3R1 17101049 106760 Negative_regulation MIP PIK3R1 24009857 203930 Negative_regulation MIP PITX3 21698120 2530411 Negative_regulation MIP PTGS2 21479220 2511193 Negative_regulation MIP SERPING1 23991040 2840615 Negative_regulation MIP SF3B3 19665392 694864 Negative_regulation MIP SIRT1 24950067 2982040 Negative_regulation MIP SPAG11B 21298000 2499275 Negative_regulation MIP TNF 9400717 797368 Negative_regulation MIP TNFRSF9 20544034 2452658 Negative_regulation MIP TNPO1 10931794 789717 Negative_regulation MIP TNPO1 25347445 3019828 Negative_regulation MIP UCHL1 23717208 3061751 Negative_regulation MIR100HG C12orf75 19531736 2046595 Negative_regulation MITF EPHB2 16129781 1323438 Negative_regulation MITF EPHB2 18628967 2392846 Negative_regulation MITF EPHB2 22363147 88172 Negative_regulation MITF EPHB2 23736765 1729773 Negative_regulation MITF MAP2K6 25278770 2123338 Negative_regulation MKNK1 EPHB2 24917786 932026 Negative_regulation MKNK1 MAP2K6 24917786 932032 Negative_regulation MKNK1 SPHK1 24917786 932024 Negative_regulation MLKL TNF 23835476 611277 Negative_regulation MLST8 EPHB2 24212825 498964 Negative_regulation MLST8 EPHB2 24303063 2887898 Negative_regulation MLST8 FAS 18776140 706720 Negative_regulation MLST8 FAS 18776140 706723 Negative_regulation MLST8 FBXO32 24765525 847688 Negative_regulation MLST8 FOXO1 22870349 696207 Negative_regulation MLST8 FOXO1 22870349 696309 Negative_regulation MLST8 FOXO1 23614736 829972 Negative_regulation MLST8 FOXO1 23614736 830017 Negative_regulation MLST8 FOXO1 23800068 830070 Negative_regulation MLST8 FOXO1 23800068 830154 Negative_regulation MLST8 FOXO1 23800068 830155 Negative_regulation MLST8 FOXO1 23800068 830203 Negative_regulation MLST8 MAP2K6 22808163 2664873 Negative_regulation MLST8 MAP2K6 23242584 477355 Negative_regulation MLST8 MAP2K6 24212825 498970 Negative_regulation MLST8 TCN1 20489726 546884 Negative_regulation MLXIPL CCND1 22751438 541607 Negative_regulation MLXIPL CCND1 22751438 541608 Negative_regulation MLXIPL CCND1 22751438 541616 Negative_regulation MLXIPL CCND1 22895168 541737 Negative_regulation MLXIPL FOXO1 23056614 2702405 Negative_regulation MLXIPL FOXO1 23056614 2702414 Negative_regulation MLYCD ITGAL 1383383 1528853 Negative_regulation MME ANGPT1 23552514 1035955 Negative_regulation MME EDN2 21951628 805470 Negative_regulation MMP1 CTGF 23041765 1086771 Negative_regulation MMP1 EDN2 20105288 328452 Negative_regulation MMP1 EPHB2 12177784 421969 Negative_regulation MMP1 EPHB2 24352036 1632408 Negative_regulation MMP1 F2R 21591259 776148 Negative_regulation MMP1 FAS 21912551 1144746 Negative_regulation MMP1 IL1B 25562599 3037222 Negative_regulation MMP1 MMP28 21591259 776147 Negative_regulation MMP1 MMP28 21591259 776205 Negative_regulation MMP1 MMP28 24198787 962703 Negative_regulation MMP1 MMP7 17286208 1639466 Negative_regulation MMP1 MMP7 21591259 776163 Negative_regulation MMP1 MMP7 21591259 776220 Negative_regulation MMP1 MMP7 24198787 962718 Negative_regulation MMP1 PCSK9 23936445 2830623 Negative_regulation MMP1 TNF 19889233 3097644 Negative_regulation MMP1 TNF 22367096 650837 Negative_regulation MMP1 TNF 22675496 2648981 Negative_regulation MMP1 TNF 24062615 1628854 Negative_regulation MMP1 TSPAN1 10491398 1249944 Negative_regulation MMP1 TSPAN1 23840773 2816520 Negative_regulation MMP10 FAS 21912551 1144747 Negative_regulation MMP10 MMP28 18778487 384801 Negative_regulation MMP10 MMP7 17286208 1639467 Negative_regulation MMP10 PCSK9 23936445 2830631 Negative_regulation MMP10 TNF 19889233 3097645 Negative_regulation MMP10 TNF 22675496 2648983 Negative_regulation MMP10 TSPAN1 10491398 1249966 Negative_regulation MMP10 TSPAN1 23840773 2816542 Negative_regulation MMP11 FAS 21912551 1144748 Negative_regulation MMP11 MMP7 17286208 1639468 Negative_regulation MMP11 PCSK9 23936445 2830639 Negative_regulation MMP11 TNF 19889233 3097646 Negative_regulation MMP11 TNF 22675496 2648985 Negative_regulation MMP11 TSPAN1 10491398 1249988 Negative_regulation MMP11 TSPAN1 23840773 2816564 Negative_regulation MMP12 FAS 21912551 1144749 Negative_regulation MMP12 MMP28 23285156 2732659 Negative_regulation MMP12 MMP7 17286208 1639469 Negative_regulation MMP12 MMP7 23285156 2732674 Negative_regulation MMP12 PCSK9 23936445 2830647 Negative_regulation MMP12 TNF 19889233 3097647 Negative_regulation MMP12 TNF 22675496 2648987 Negative_regulation MMP12 TSPAN1 10491398 1250010 Negative_regulation MMP12 TSPAN1 23840773 2816586 Negative_regulation MMP13 FAS 21912551 1144750 Negative_regulation MMP13 MAP2K6 17576777 1546506 Negative_regulation MMP13 MMP28 23226927 1750974 Negative_regulation MMP13 MMP7 17286208 1639470 Negative_regulation MMP13 MMP7 23226927 1750989 Negative_regulation MMP13 PCSK9 23936445 2830655 Negative_regulation MMP13 TNF 19889233 3097648 Negative_regulation MMP13 TNF 22388073 14503 Negative_regulation MMP13 TNF 22675496 2648989 Negative_regulation MMP13 TSPAN1 10491398 1250032 Negative_regulation MMP13 TSPAN1 23840773 2816608 Negative_regulation MMP14 CAPN8 22407449 87010 Negative_regulation MMP14 CAPN8 22407449 87143 Negative_regulation MMP14 EPHB2 24180670 270276 Negative_regulation MMP14 FAS 21912551 1144751 Negative_regulation MMP14 MAP2K6 22310287 2146237 Negative_regulation MMP14 MMP28 24156018 492106 Negative_regulation MMP14 MMP7 17286208 1639471 Negative_regulation MMP14 MMP7 24156018 492121 Negative_regulation MMP14 PCSK9 23936445 2830663 Negative_regulation MMP14 TNF 19889233 3097649 Negative_regulation MMP14 TNF 22675496 2648991 Negative_regulation MMP14 TSPAN1 10491398 1250054 Negative_regulation MMP14 TSPAN1 23840773 2816630 Negative_regulation MMP15 FAS 21912551 1144752 Negative_regulation MMP15 MMP28 16151515 2301985 Negative_regulation MMP15 MMP7 16151515 2302000 Negative_regulation MMP15 MMP7 17286208 1639472 Negative_regulation MMP15 PCSK9 23936445 2830671 Negative_regulation MMP15 TNF 19889233 3097650 Negative_regulation MMP15 TNF 22675496 2648993 Negative_regulation MMP15 TSPAN1 10491398 1250076 Negative_regulation MMP15 TSPAN1 23840773 2816652 Negative_regulation MMP16 FAS 21912551 1144753 Negative_regulation MMP16 MMP28 16151515 2302007 Negative_regulation MMP16 MMP7 16151515 2302022 Negative_regulation MMP16 MMP7 17286208 1639473 Negative_regulation MMP16 PCSK9 23936445 2830679 Negative_regulation MMP16 TNF 19889233 3097651 Negative_regulation MMP16 TNF 22675496 2648995 Negative_regulation MMP16 TSPAN1 10491398 1250098 Negative_regulation MMP16 TSPAN1 23840773 2816674 Negative_regulation MMP17 FAS 21912551 1144754 Negative_regulation MMP17 MMP7 17286208 1639474 Negative_regulation MMP17 PCSK9 23936445 2830687 Negative_regulation MMP17 TNF 19889233 3097652 Negative_regulation MMP17 TNF 22675496 2648997 Negative_regulation MMP17 TSPAN1 10491398 1250120 Negative_regulation MMP17 TSPAN1 23840773 2816696 Negative_regulation MMP19 CLDN10 23752226 1572406 Negative_regulation MMP19 FAS 21912551 1144755 Negative_regulation MMP19 MMP7 17286208 1639475 Negative_regulation MMP19 PCSK9 23936445 2830695 Negative_regulation MMP19 TNF 19889233 3097653 Negative_regulation MMP19 TNF 22675496 2648999 Negative_regulation MMP19 TSPAN1 10491398 1250142 Negative_regulation MMP19 TSPAN1 23840773 2816718 Negative_regulation MMP2 ALOX5 22529515 1749689 Negative_regulation MMP2 CST6 24742492 2188912 Negative_regulation MMP2 EMP1 9459141 446786 Negative_regulation MMP2 EMP1 9459141 446789 Negative_regulation MMP2 EPHB2 20226009 255642 Negative_regulation MMP2 EPHB2 21569377 1658374 Negative_regulation MMP2 EPHB2 23710144 3154631 Negative_regulation MMP2 EPHB2 24351905 1730441 Negative_regulation MMP2 EPHB2 25184134 198735 Negative_regulation MMP2 FAS 21573233 2522994 Negative_regulation MMP2 FAS 21912551 1144756 Negative_regulation MMP2 ID1 23714001 1699831 Negative_regulation MMP2 MAP2K6 22310287 2146223 Negative_regulation MMP2 MMP28 18778487 384802 Negative_regulation MMP2 MMP28 23638054 2787362 Negative_regulation MMP2 MMP28 25136829 2998945 Negative_regulation MMP2 MMP28 25580270 848518 Negative_regulation MMP2 MMP7 17286208 1639476 Negative_regulation MMP2 MMP7 23638054 2787377 Negative_regulation MMP2 MMP7 25136829 2998960 Negative_regulation MMP2 MMP7 25580270 848533 Negative_regulation MMP2 PCSK9 23936445 2830703 Negative_regulation MMP2 PLAT 21679435 845878 Negative_regulation MMP2 PLAU 23457587 2758840 Negative_regulation MMP2 PLAU 25222667 1730972 Negative_regulation MMP2 TNF 11132772 1737230 Negative_regulation MMP2 TNF 12966436 423290 Negative_regulation MMP2 TNF 19281093 1071727 Negative_regulation MMP2 TNF 19889233 3097654 Negative_regulation MMP2 TNF 21067565 397478 Negative_regulation MMP2 TNF 21569377 1658329 Negative_regulation MMP2 TNF 21569377 1658330 Negative_regulation MMP2 TNF 21569377 1658334 Negative_regulation MMP2 TNF 21569377 1658335 Negative_regulation MMP2 TNF 21569377 1658338 Negative_regulation MMP2 TNF 21569377 1658342 Negative_regulation MMP2 TNF 22675496 2649001 Negative_regulation MMP2 TNF 24085323 1142192 Negative_regulation MMP2 TNFSF10 21209944 2492517 Negative_regulation MMP2 TNFSF10 21209944 2492519 Negative_regulation MMP2 TNFSF10 22962598 2686954 Negative_regulation MMP2 TSPAN1 10491398 1250164 Negative_regulation MMP2 TSPAN1 23840773 2816740 Negative_regulation MMP2 WIF1 20573255 1856519 Negative_regulation MMP20 FAS 21912551 1144757 Negative_regulation MMP20 MMP7 17286208 1639477 Negative_regulation MMP20 PCSK9 23936445 2830711 Negative_regulation MMP20 TNF 19889233 3097655 Negative_regulation MMP20 TNF 22675496 2649003 Negative_regulation MMP20 TSPAN1 10491398 1250186 Negative_regulation MMP20 TSPAN1 23840773 2816762 Negative_regulation MMP21 FAS 21912551 1144743 Negative_regulation MMP21 MMP7 17286208 1639464 Negative_regulation MMP21 PCSK9 23936445 2830584 Negative_regulation MMP21 TNF 19889233 3097642 Negative_regulation MMP21 TNF 22675496 2648977 Negative_regulation MMP21 TSPAN1 10491398 1249900 Negative_regulation MMP21 TSPAN1 23840773 2816476 Negative_regulation MMP24 FAS 21912551 1144758 Negative_regulation MMP24 MMP7 17286208 1639478 Negative_regulation MMP24 PCSK9 23936445 2830719 Negative_regulation MMP24 TNF 19889233 3097656 Negative_regulation MMP24 TNF 22675496 2649005 Negative_regulation MMP24 TSPAN1 10491398 1250208 Negative_regulation MMP24 TSPAN1 23840773 2816784 Negative_regulation MMP25 FAS 21912551 1144740 Negative_regulation MMP25 MMP7 17286208 1639461 Negative_regulation MMP25 PCSK9 23936445 2830560 Negative_regulation MMP25 TNF 19889233 3097639 Negative_regulation MMP25 TNF 22675496 2648971 Negative_regulation MMP25 TSPAN1 10491398 1249834 Negative_regulation MMP25 TSPAN1 23840773 2816410 Negative_regulation MMP26 FAS 21912551 1144741 Negative_regulation MMP26 MMP7 17286208 1639462 Negative_regulation MMP26 PCSK9 23936445 2830568 Negative_regulation MMP26 TNF 19889233 3097640 Negative_regulation MMP26 TNF 22675496 2648973 Negative_regulation MMP26 TSPAN1 10491398 1249856 Negative_regulation MMP26 TSPAN1 23840773 2816432 Negative_regulation MMP27 FAS 21912551 1144742 Negative_regulation MMP27 MMP7 17286208 1639463 Negative_regulation MMP27 PCSK9 23936445 2830576 Negative_regulation MMP27 TNF 19889233 3097641 Negative_regulation MMP27 TNF 22675496 2648975 Negative_regulation MMP27 TSPAN1 10491398 1249878 Negative_regulation MMP27 TSPAN1 23840773 2816454 Negative_regulation MMP28 A2M 22778955 1144592 Negative_regulation MMP28 ADCY1 23249435 398785 Negative_regulation MMP28 ADCY10 23249435 398784 Negative_regulation MMP28 ADCY2 23249435 398786 Negative_regulation MMP28 ADCY3 23249435 398787 Negative_regulation MMP28 ADCY4 23249435 398788 Negative_regulation MMP28 ADCY5 23249435 398789 Negative_regulation MMP28 ADCY6 23249435 398790 Negative_regulation MMP28 ADCY7 23249435 398791 Negative_regulation MMP28 ADCY8 23249435 398792 Negative_regulation MMP28 ADCY9 23249435 398793 Negative_regulation MMP28 ADIPOQ 24434628 840299 Negative_regulation MMP28 AKT1 23061721 533221 Negative_regulation MMP28 AKT1 25036034 1128437 Negative_regulation MMP28 AKT1 25147440 1761312 Negative_regulation MMP28 AKT2 23061721 533222 Negative_regulation MMP28 AKT2 25036034 1128438 Negative_regulation MMP28 AKT2 25147440 1761313 Negative_regulation MMP28 AKT3 23061721 533223 Negative_regulation MMP28 AKT3 25036034 1128439 Negative_regulation MMP28 AKT3 25147440 1761314 Negative_regulation MMP28 ARF6 20418905 2130838 Negative_regulation MMP28 BAX 24808916 825827 Negative_regulation MMP28 BCL2 11181702 1518612 Negative_regulation MMP28 BCL2 12756268 1527321 Negative_regulation MMP28 BNIP3 22292033 2592109 Negative_regulation MMP28 BSG 19664212 116314 Negative_regulation MMP28 CAPN2 22629380 2645384 Negative_regulation MMP28 CAPNS1 22629380 2645385 Negative_regulation MMP28 CASP1 12925707 1295723 Negative_regulation MMP28 CASP1 19715609 1851385 Negative_regulation MMP28 CASP1 24091661 566730 Negative_regulation MMP28 CASP1 24260080 2167148 Negative_regulation MMP28 CASP10 12925707 1295724 Negative_regulation MMP28 CASP10 19715609 1851386 Negative_regulation MMP28 CASP10 24091661 566731 Negative_regulation MMP28 CASP10 24260080 2167149 Negative_regulation MMP28 CASP12 12925707 1295734 Negative_regulation MMP28 CASP12 19715609 1851396 Negative_regulation MMP28 CASP12 24091661 566741 Negative_regulation MMP28 CASP12 24260080 2167159 Negative_regulation MMP28 CASP14 12925707 1295725 Negative_regulation MMP28 CASP14 19715609 1851387 Negative_regulation MMP28 CASP14 24091661 566732 Negative_regulation MMP28 CASP14 24260080 2167150 Negative_regulation MMP28 CASP16 12925707 1295735 Negative_regulation MMP28 CASP16 19715609 1851397 Negative_regulation MMP28 CASP16 24091661 566742 Negative_regulation MMP28 CASP16 24260080 2167160 Negative_regulation MMP28 CASP2 12925707 1295726 Negative_regulation MMP28 CASP2 19715609 1851388 Negative_regulation MMP28 CASP2 24091661 566733 Negative_regulation MMP28 CASP2 24260080 2167151 Negative_regulation MMP28 CASP3 12925707 1295727 Negative_regulation MMP28 CASP3 18629305 793247 Negative_regulation MMP28 CASP3 19715609 1851389 Negative_regulation MMP28 CASP3 24091661 566734 Negative_regulation MMP28 CASP3 24260080 2167152 Negative_regulation MMP28 CASP4 12925707 1295728 Negative_regulation MMP28 CASP4 19715609 1851390 Negative_regulation MMP28 CASP4 24091661 566735 Negative_regulation MMP28 CASP4 24260080 2167153 Negative_regulation MMP28 CASP5 12925707 1295729 Negative_regulation MMP28 CASP5 19715609 1851391 Negative_regulation MMP28 CASP5 24091661 566736 Negative_regulation MMP28 CASP5 24260080 2167154 Negative_regulation MMP28 CASP6 12925707 1295730 Negative_regulation MMP28 CASP6 19715609 1851392 Negative_regulation MMP28 CASP6 24091661 566737 Negative_regulation MMP28 CASP6 24260080 2167155 Negative_regulation MMP28 CASP7 12925707 1295731 Negative_regulation MMP28 CASP7 19715609 1851393 Negative_regulation MMP28 CASP7 24091661 566738 Negative_regulation MMP28 CASP7 24260080 2167156 Negative_regulation MMP28 CASP8 12925707 1295732 Negative_regulation MMP28 CASP8 19715609 1851394 Negative_regulation MMP28 CASP8 24091661 566739 Negative_regulation MMP28 CASP8 24260080 2167157 Negative_regulation MMP28 CASP9 12925707 1295733 Negative_regulation MMP28 CASP9 18629305 793248 Negative_regulation MMP28 CASP9 19715609 1851395 Negative_regulation MMP28 CASP9 24091661 566740 Negative_regulation MMP28 CASP9 24260080 2167158 Negative_regulation MMP28 CASP9 25009698 206312 Negative_regulation MMP28 CAV1 22842734 15750 Negative_regulation MMP28 CCNB1 19789215 811488 Negative_regulation MMP28 CCR7 19363519 7364 Negative_regulation MMP28 CD2 18629305 793249 Negative_regulation MMP28 CD2 18629305 793250 Negative_regulation MMP28 CD40 20921282 1560524 Negative_regulation MMP28 CD40 20921282 1560525 Negative_regulation MMP28 CDKN1A 24523890 2921843 Negative_regulation MMP28 CEBPA 18366750 322990 Negative_regulation MMP28 CHUK 22359588 2597996 Negative_regulation MMP28 CLASP1 24859005 1930782 Negative_regulation MMP28 CLASP2 24859005 1930781 Negative_regulation MMP28 CTSB 21092330 481753 Negative_regulation MMP28 CXCL12 22675496 2648978 Negative_regulation MMP28 CXCL13 21533157 2515267 Negative_regulation MMP28 CYCS 19636435 1212845 Negative_regulation MMP28 CYCS 19966836 8490 Negative_regulation MMP28 CYCS 25505905 23341 Negative_regulation MMP28 DHDDS 22303396 882172 Negative_regulation MMP28 ECM1 12011115 1283021 Negative_regulation MMP28 ECM2 12011115 1283022 Negative_regulation MMP28 EDN1 16503991 507431 Negative_regulation MMP28 EDNRB 25383546 3024180 Negative_regulation MMP28 ERVK-6 24455428 3151080 Negative_regulation MMP28 ETV1 21673681 436886 Negative_regulation MMP28 FAS 21912551 1144744 Negative_regulation MMP28 FASLG 7500022 1587148 Negative_regulation MMP28 FMR1 22685676 2002599 Negative_regulation MMP28 FN1 18001488 109373 Negative_regulation MMP28 FURIN 23936445 2830520 Negative_regulation MMP28 FURIN 23936445 2830593 Negative_regulation MMP28 GLRX 18560520 2390878 Negative_regulation MMP28 GLRX 18560520 2390968 Negative_regulation MMP28 GLRX 18560520 2391012 Negative_regulation MMP28 GLRX 18560520 2391056 Negative_regulation MMP28 GUCY2D 23940835 2236589 Negative_regulation MMP28 HDAC1 15899037 103415 Negative_regulation MMP28 HDAC1 21801383 1652096 Negative_regulation MMP28 HDAC1 24062615 1628553 Negative_regulation MMP28 HDAC2 15899037 103416 Negative_regulation MMP28 HDAC2 21801383 1652097 Negative_regulation MMP28 HDAC2 24062615 1628554 Negative_regulation MMP28 HPSE 19360105 2412763 Negative_regulation MMP28 HPSE 22590508 2640716 Negative_regulation MMP28 HPX 16542425 249169 Negative_regulation MMP28 IDO1 11375052 224768 Negative_regulation MMP28 IGF1 18513402 110898 Negative_regulation MMP28 IGF1 21637514 989523 Negative_regulation MMP28 IGF2 18513402 110899 Negative_regulation MMP28 IKBKB 22359588 2597997 Negative_regulation MMP28 IKBKG 22359588 2597998 Negative_regulation MMP28 IL10 24878845 2975473 Negative_regulation MMP28 IL1A 15535839 101916 Negative_regulation MMP28 IL2 20921282 1560526 Negative_regulation MMP28 IL33 23525523 1712105 Negative_regulation MMP28 INS 20828387 508159 Negative_regulation MMP28 ITGA2 21288331 855224 Negative_regulation MMP28 JUN 20964825 855139 Negative_regulation MMP28 JUN 9888461 448003 Negative_regulation MMP28 LEP 24202338 497525 Negative_regulation MMP28 LPO 25505905 23342 Negative_regulation MMP28 LTB 12516548 2001344 Negative_regulation MMP28 MCS 23342045 2741798 Negative_regulation MMP28 MIR146B 23510696 3169337 Negative_regulation MMP28 MMP1 11027427 417851 Negative_regulation MMP28 MMP1 24198787 962697 Negative_regulation MMP28 MMP10 18778487 384799 Negative_regulation MMP28 MMP12 17668061 2377340 Negative_regulation MMP28 MMP13 23226927 1750960 Negative_regulation MMP28 MMP19 17668061 2377341 Negative_regulation MMP28 MMP2 18778487 384800 Negative_regulation MMP28 MMP2 23638054 2787345 Negative_regulation MMP28 MMP2 23991045 2840692 Negative_regulation MMP28 MMP2 25136829 2998930 Negative_regulation MMP28 MMP2 25580270 848503 Negative_regulation MMP28 MMP3 17668061 2377342 Negative_regulation MMP28 MMP7 17286208 1639465 Negative_regulation MMP28 MMP9 18288287 3072025 Negative_regulation MMP28 MMP9 22848429 2668908 Negative_regulation MMP28 MMP9 23570271 1836563 Negative_regulation MMP28 MMP9 23945132 1481415 Negative_regulation MMP28 MMP9 24198787 962698 Negative_regulation MMP28 MMP9 24228622 359302 Negative_regulation MMP28 MOK 18511846 706139 Negative_regulation MMP28 MPST 23626836 2785017 Negative_regulation MMP28 MRC1 23937653 380301 Negative_regulation MMP28 MRC2 23937653 380300 Negative_regulation MMP28 MSLN 23694968 3135875 Negative_regulation MMP28 MTOR PMC4212306 3206535 Negative_regulation MMP28 MYLIP 24191129 737425 Negative_regulation MMP28 NOX1 23840100 1753540 Negative_regulation MMP28 NOX3 23840100 1753541 Negative_regulation MMP28 NOX4 23840100 1753542 Negative_regulation MMP28 NOX5 23840100 1753539 Negative_regulation MMP28 OPN1MW 22523714 1154731 Negative_regulation MMP28 PAEP 23185522 2721492 Negative_regulation MMP28 PCSK1 23936445 2830595 Negative_regulation MMP28 PCSK2 23936445 2830596 Negative_regulation MMP28 PCSK4 23936445 2830597 Negative_regulation MMP28 PCSK5 23936445 2830598 Negative_regulation MMP28 PCSK6 23936445 2830594 Negative_regulation MMP28 PCSK7 23936445 2830599 Negative_regulation MMP28 PCSK9 23936445 2830592 Negative_regulation MMP28 PDGFB 23226927 1750961 Negative_regulation MMP28 PIK3CA 23061721 533224 Negative_regulation MMP28 PIK3CA 25147440 1761315 Negative_regulation MMP28 PIK3R1 23061721 533225 Negative_regulation MMP28 PIK3R1 25147440 1761316 Negative_regulation MMP28 PIP 19765281 116720 Negative_regulation MMP28 PLOD2 20148173 2214669 Negative_regulation MMP28 PRDX2 22848731 2670230 Negative_regulation MMP28 PRG2 18205922 109860 Negative_regulation MMP28 PRG2 22529468 1047434 Negative_regulation MMP28 PRG3 18205922 109861 Negative_regulation MMP28 PRG3 22529468 1047435 Negative_regulation MMP28 PRG4 18205922 109862 Negative_regulation MMP28 PRG4 22529468 1047436 Negative_regulation MMP28 PTGS2 16831226 249472 Negative_regulation MMP28 PTGS2 23552603 2156163 Negative_regulation MMP28 RAD1 23840275 820979 Negative_regulation MMP28 RAD17 23840275 820980 Negative_regulation MMP28 RAD18 23840275 820978 Negative_regulation MMP28 RAD21 23840275 820981 Negative_regulation MMP28 RAD50 23840275 820982 Negative_regulation MMP28 RAD51 23840275 820983 Negative_regulation MMP28 RAD52 23840275 820984 Negative_regulation MMP28 RANBP9 23348590 559246 Negative_regulation MMP28 RANBP9 23348590 559270 Negative_regulation MMP28 RANBP9 23348590 559292 Negative_regulation MMP28 RBBP4 15899037 103417 Negative_regulation MMP28 RBBP4 21801383 1652098 Negative_regulation MMP28 RBBP4 24062615 1628555 Negative_regulation MMP28 RBBP7 15899037 103418 Negative_regulation MMP28 RBBP7 21801383 1652099 Negative_regulation MMP28 RBBP7 24062615 1628556 Negative_regulation MMP28 RECK 12100737 457375 Negative_regulation MMP28 RECK 18665171 430819 Negative_regulation MMP28 RECK 21731450 1091221 Negative_regulation MMP28 RECK 22048456 988698 Negative_regulation MMP28 RECK 22260435 263135 Negative_regulation MMP28 RECK 22260435 263136 Negative_regulation MMP28 RECK 22347664 1150677 Negative_regulation MMP28 RECK 22419890 1059916 Negative_regulation MMP28 RECK 23509776 180266 Negative_regulation MMP28 RECK 24376819 2902316 Negative_regulation MMP28 RECK 24765174 2168214 Negative_regulation MMP28 RECK 24891760 1759170 Negative_regulation MMP28 REG1A 23690852 819161 Negative_regulation MMP28 RHOA 20843370 1504486 Negative_regulation MMP28 S100A4 23922901 2827422 Negative_regulation MMP28 SDF2 23442825 87606 Negative_regulation MMP28 SDF4 23442825 87607 Negative_regulation MMP28 SERPINE1 23724005 2798864 Negative_regulation MMP28 SFN 23662110 818728 Negative_regulation MMP28 SFN 23983046 135639 Negative_regulation MMP28 SFN 23983046 135677 Negative_regulation MMP28 SIRT1 20920189 3111336 Negative_regulation MMP28 SLC12A9 24523890 2921842 Negative_regulation MMP28 SLC25A1 24471092 3077358 Negative_regulation MMP28 SLC25A27 22427795 2610125 Negative_regulation MMP28 SLC39A4 23857777 781388 Negative_regulation MMP28 SLC9A1 PMC2756345 496255 Negative_regulation MMP28 SPOCK1 18205922 109830 Negative_regulation MMP28 SRR 22629429 2646456 Negative_regulation MMP28 SSFA2 7537277 1436559 Negative_regulation MMP28 SSFA2 7537277 1436648 Negative_regulation MMP28 SSFA2 7537277 1436670 Negative_regulation MMP28 TGFB1I1 24811612 1159506 Negative_regulation MMP28 TGFB1I1 24811612 1159507 Negative_regulation MMP28 TGFBRAP1 17638420 2263210 Negative_regulation MMP28 TIMP1 10459021 1249144 Negative_regulation MMP28 TIMP1 12718745 99712 Negative_regulation MMP28 TIMP1 12718745 99738 Negative_regulation MMP28 TIMP1 12975354 1297233 Negative_regulation MMP28 TIMP1 15642138 102335 Negative_regulation MMP28 TIMP1 15701164 480151 Negative_regulation MMP28 TIMP1 16478544 365189 Negative_regulation MMP28 TIMP1 17668061 2377339 Negative_regulation MMP28 TIMP1 17980029 461763 Negative_regulation MMP28 TIMP1 19390643 1909173 Negative_regulation MMP28 TIMP1 19479048 2417518 Negative_regulation MMP28 TIMP1 19961576 854771 Negative_regulation MMP28 TIMP1 20148173 2214668 Negative_regulation MMP28 TIMP1 20169175 2001840 Negative_regulation MMP28 TIMP1 20540791 1855757 Negative_regulation MMP28 TIMP1 21092330 481752 Negative_regulation MMP28 TIMP1 21711826 519334 Negative_regulation MMP28 TIMP1 21923935 514834 Negative_regulation MMP28 TIMP1 22078297 1008876 Negative_regulation MMP28 TIMP1 22701711 2652111 Negative_regulation MMP28 TIMP1 22739984 556107 Negative_regulation MMP28 TIMP1 22937143 2683085 Negative_regulation MMP28 TIMP1 23018346 1735676 Negative_regulation MMP28 TIMP1 23185522 2721491 Negative_regulation MMP28 TIMP1 23750094 163605 Negative_regulation MMP28 TIMP1 23786632 1666778 Negative_regulation MMP28 TIMP1 23829630 294501 Negative_regulation MMP28 TIMP1 23873298 1108826 Negative_regulation MMP28 TIMP1 23986797 83147 Negative_regulation MMP28 TIMP1 24137341 2165511 Negative_regulation MMP28 TIMP1 24156369 138888 Negative_regulation MMP28 TIMP1 24156369 138910 Negative_regulation MMP28 TIMP1 24278882 1498571 Negative_regulation MMP28 TIMP1 24330623 270973 Negative_regulation MMP28 TIMP1 24475101 2914803 Negative_regulation MMP28 TIMP1 24616631 3156103 Negative_regulation MMP28 TIMP1 24616654 3156131 Negative_regulation MMP28 TIMP1 24675764 2372512 Negative_regulation MMP28 TIMP1 24733017 2952382 Negative_regulation MMP28 TIMP1 25107295 647580 Negative_regulation MMP28 TIMP1 25121738 2997264 Negative_regulation MMP28 TIMP1 25205985 90197 Negative_regulation MMP28 TIMP1 25557794 1605946 Negative_regulation MMP28 TIMP2 10682680 416304 Negative_regulation MMP28 TIMP2 10851027 1259210 Negative_regulation MMP28 TIMP2 12427868 1287863 Negative_regulation MMP28 TIMP2 17179989 428407 Negative_regulation MMP28 TIMP2 21349159 3206939 Negative_regulation MMP28 TIMP2 22048456 988699 Negative_regulation MMP28 TIMP2 22318811 3232870 Negative_regulation MMP28 TIMP2 22739984 556108 Negative_regulation MMP28 TIMP2 23300891 2737193 Negative_regulation MMP28 TIMP2 23598418 1105947 Negative_regulation MMP28 TIMP2 23894327 2824143 Negative_regulation MMP28 TIMP2 23970935 822403 Negative_regulation MMP28 TIMP2 23991045 2840691 Negative_regulation MMP28 TIMP2 24137341 2165512 Negative_regulation MMP28 TIMP2 24231999 1137897 Negative_regulation MMP28 TIMP2 24376839 2902408 Negative_regulation MMP28 TIMP2 24520285 2167597 Negative_regulation MMP28 TIMP2 25329658 3016250 Negative_regulation MMP28 TIMP3 21349159 3206940 Negative_regulation MMP28 TIMP3 22739984 556109 Negative_regulation MMP28 TIMP3 23509776 180267 Negative_regulation MMP28 TIMP3 24191129 737424 Negative_regulation MMP28 TIMP4 24733017 2952383 Negative_regulation MMP28 TIMP4 25114377 1760364 Negative_regulation MMP28 TLR9 24959259 2168921 Negative_regulation MMP28 TMED7 24690323 540135 Negative_regulation MMP28 TNF 19889233 3097643 Negative_regulation MMP28 TNF 22675496 2648979 Negative_regulation MMP28 TP53 24690323 540134 Negative_regulation MMP28 TSPAN1 10491398 1249922 Negative_regulation MMP28 TSPAN1 23840773 2816498 Negative_regulation MMP28 TSPAN10 10491398 1249931 Negative_regulation MMP28 TSPAN10 23840773 2816507 Negative_regulation MMP28 TSPAN11 10491398 1249933 Negative_regulation MMP28 TSPAN11 23840773 2816509 Negative_regulation MMP28 TSPAN12 10491398 1249926 Negative_regulation MMP28 TSPAN12 23840773 2816502 Negative_regulation MMP28 TSPAN13 10491398 1249927 Negative_regulation MMP28 TSPAN13 23840773 2816503 Negative_regulation MMP28 TSPAN14 10491398 1249929 Negative_regulation MMP28 TSPAN14 23840773 2816505 Negative_regulation MMP28 TSPAN15 10491398 1249928 Negative_regulation MMP28 TSPAN15 23840773 2816504 Negative_regulation MMP28 TSPAN16 10491398 1249932 Negative_regulation MMP28 TSPAN16 23840773 2816508 Negative_regulation MMP28 TSPAN17 10491398 1249919 Negative_regulation MMP28 TSPAN17 23840773 2816495 Negative_regulation MMP28 TSPAN18 10491398 1249924 Negative_regulation MMP28 TSPAN18 23840773 2816500 Negative_regulation MMP28 TSPAN19 10491398 1249934 Negative_regulation MMP28 TSPAN19 23840773 2816510 Negative_regulation MMP28 TSPAN2 10491398 1249923 Negative_regulation MMP28 TSPAN2 23840773 2816499 Negative_regulation MMP28 TSPAN3 10491398 1249920 Negative_regulation MMP28 TSPAN3 23840773 2816496 Negative_regulation MMP28 TSPAN31 10491398 1249913 Negative_regulation MMP28 TSPAN31 23840773 2816489 Negative_regulation MMP28 TSPAN32 10491398 1249918 Negative_regulation MMP28 TSPAN32 23840773 2816494 Negative_regulation MMP28 TSPAN33 10491398 1249930 Negative_regulation MMP28 TSPAN33 23840773 2816506 Negative_regulation MMP28 TSPAN4 10491398 1249917 Negative_regulation MMP28 TSPAN4 23840773 2816493 Negative_regulation MMP28 TSPAN5 10491398 1249921 Negative_regulation MMP28 TSPAN5 23840773 2816497 Negative_regulation MMP28 TSPAN6 10491398 1249916 Negative_regulation MMP28 TSPAN6 23840773 2816492 Negative_regulation MMP28 TSPAN7 10491398 1249914 Negative_regulation MMP28 TSPAN7 23840773 2816490 Negative_regulation MMP28 TSPAN8 10491398 1249915 Negative_regulation MMP28 TSPAN8 23840773 2816491 Negative_regulation MMP28 TSPAN9 10491398 1249925 Negative_regulation MMP28 TSPAN9 23840773 2816501 Negative_regulation MMP28 TYR 24243820 2185476 Negative_regulation MMP28 UCP2 17472436 2262953 Negative_regulation MMP28 VEGFA 22056617 13846 Negative_regulation MMP28 VEGFA 22848429 2668907 Negative_regulation MMP28 WNK1 22359588 2597995 Negative_regulation MMP28 WNK1 24238405 129941 Negative_regulation MMP3 ALOX5 21060724 1084118 Negative_regulation MMP3 CA12 21201390 2875 Negative_regulation MMP3 CA12 22942690 1096955 Negative_regulation MMP3 FAS 21912551 1144759 Negative_regulation MMP3 MMP28 24403829 1138128 Negative_regulation MMP3 MMP28 24403829 1138129 Negative_regulation MMP3 MMP7 17286208 1639479 Negative_regulation MMP3 MMP7 24403829 1138158 Negative_regulation MMP3 MMP7 24403829 1138159 Negative_regulation MMP3 PCSK9 23936445 2830727 Negative_regulation MMP3 TNF 19889233 3097657 Negative_regulation MMP3 TNF 22675496 2649007 Negative_regulation MMP3 TSPAN1 10491398 1250230 Negative_regulation MMP3 TSPAN1 23840773 2816806 Negative_regulation MMP7 A2M 22778955 1144607 Negative_regulation MMP7 ADCY1 23249435 398935 Negative_regulation MMP7 ADCY10 23249435 398934 Negative_regulation MMP7 ADCY2 23249435 398936 Negative_regulation MMP7 ADCY3 23249435 398937 Negative_regulation MMP7 ADCY4 23249435 398938 Negative_regulation MMP7 ADCY5 23249435 398939 Negative_regulation MMP7 ADCY6 23249435 398940 Negative_regulation MMP7 ADCY7 23249435 398941 Negative_regulation MMP7 ADCY8 23249435 398942 Negative_regulation MMP7 ADCY9 23249435 398943 Negative_regulation MMP7 ADIPOQ 24434628 840314 Negative_regulation MMP7 AKT1 23061721 533296 Negative_regulation MMP7 AKT1 25036034 1128482 Negative_regulation MMP7 AKT1 25147440 1761387 Negative_regulation MMP7 AKT2 23061721 533297 Negative_regulation MMP7 AKT2 25036034 1128483 Negative_regulation MMP7 AKT2 25147440 1761388 Negative_regulation MMP7 AKT3 23061721 533298 Negative_regulation MMP7 AKT3 25036034 1128484 Negative_regulation MMP7 AKT3 25147440 1761389 Negative_regulation MMP7 ARF6 20418905 2130853 Negative_regulation MMP7 ASCL1 23300791 2735980 Negative_regulation MMP7 ASCL1 23300791 2735987 Negative_regulation MMP7 BAX 24808916 825855 Negative_regulation MMP7 BCL2 11181702 1518627 Negative_regulation MMP7 BCL2 12756268 1527336 Negative_regulation MMP7 BNIP3 22292033 2592124 Negative_regulation MMP7 BSG 19664212 116329 Negative_regulation MMP7 CAPN2 22629380 2645414 Negative_regulation MMP7 CAPNS1 22629380 2645415 Negative_regulation MMP7 CASP1 12925707 1295918 Negative_regulation MMP7 CASP1 19715609 1851580 Negative_regulation MMP7 CASP1 24091661 566925 Negative_regulation MMP7 CASP1 24260080 2167356 Negative_regulation MMP7 CASP10 12925707 1295919 Negative_regulation MMP7 CASP10 19715609 1851581 Negative_regulation MMP7 CASP10 24091661 566926 Negative_regulation MMP7 CASP10 24260080 2167357 Negative_regulation MMP7 CASP12 12925707 1295929 Negative_regulation MMP7 CASP12 19715609 1851591 Negative_regulation MMP7 CASP12 24091661 566936 Negative_regulation MMP7 CASP12 24260080 2167367 Negative_regulation MMP7 CASP14 12925707 1295920 Negative_regulation MMP7 CASP14 19715609 1851582 Negative_regulation MMP7 CASP14 24091661 566927 Negative_regulation MMP7 CASP14 24260080 2167358 Negative_regulation MMP7 CASP16 12925707 1295930 Negative_regulation MMP7 CASP16 19715609 1851592 Negative_regulation MMP7 CASP16 24091661 566937 Negative_regulation MMP7 CASP16 24260080 2167368 Negative_regulation MMP7 CASP2 12925707 1295921 Negative_regulation MMP7 CASP2 19715609 1851583 Negative_regulation MMP7 CASP2 24091661 566928 Negative_regulation MMP7 CASP2 24260080 2167359 Negative_regulation MMP7 CASP3 12925707 1295922 Negative_regulation MMP7 CASP3 18629305 793330 Negative_regulation MMP7 CASP3 19715609 1851584 Negative_regulation MMP7 CASP3 24091661 566929 Negative_regulation MMP7 CASP3 24260080 2167360 Negative_regulation MMP7 CASP4 12925707 1295923 Negative_regulation MMP7 CASP4 19715609 1851585 Negative_regulation MMP7 CASP4 24091661 566930 Negative_regulation MMP7 CASP4 24260080 2167361 Negative_regulation MMP7 CASP5 12925707 1295924 Negative_regulation MMP7 CASP5 19715609 1851586 Negative_regulation MMP7 CASP5 24091661 566931 Negative_regulation MMP7 CASP5 24260080 2167362 Negative_regulation MMP7 CASP6 12925707 1295925 Negative_regulation MMP7 CASP6 19715609 1851587 Negative_regulation MMP7 CASP6 24091661 566932 Negative_regulation MMP7 CASP6 24260080 2167363 Negative_regulation MMP7 CASP7 12925707 1295926 Negative_regulation MMP7 CASP7 19715609 1851588 Negative_regulation MMP7 CASP7 24091661 566933 Negative_regulation MMP7 CASP7 24260080 2167364 Negative_regulation MMP7 CASP8 12925707 1295927 Negative_regulation MMP7 CASP8 19715609 1851589 Negative_regulation MMP7 CASP8 24091661 566934 Negative_regulation MMP7 CASP8 24260080 2167365 Negative_regulation MMP7 CASP9 12925707 1295928 Negative_regulation MMP7 CASP9 18629305 793331 Negative_regulation MMP7 CASP9 19715609 1851590 Negative_regulation MMP7 CASP9 24091661 566935 Negative_regulation MMP7 CASP9 24260080 2167366 Negative_regulation MMP7 CASP9 25009698 206349 Negative_regulation MMP7 CAV1 22842734 15787 Negative_regulation MMP7 CCNB1 19789215 811503 Negative_regulation MMP7 CCR7 19363519 7379 Negative_regulation MMP7 CD2 18629305 793332 Negative_regulation MMP7 CD2 18629305 793333 Negative_regulation MMP7 CD40 20921282 1560594 Negative_regulation MMP7 CD40 20921282 1560595 Negative_regulation MMP7 CDH11 22139084 2144749 Negative_regulation MMP7 CDKN1A 24523890 2921873 Negative_regulation MMP7 CEBPA 18366750 323005 Negative_regulation MMP7 CHUK 22359588 2598148 Negative_regulation MMP7 CLASP1 24859005 1930812 Negative_regulation MMP7 CLASP2 24859005 1930811 Negative_regulation MMP7 CSE 24284399 1121767 Negative_regulation MMP7 CTSB 21092330 481806 Negative_regulation MMP7 CXCL12 22675496 2649008 Negative_regulation MMP7 CXCL13 21533157 2515282 Negative_regulation MMP7 CYCS 19636435 1212860 Negative_regulation MMP7 CYCS 19966836 8505 Negative_regulation MMP7 CYCS 25505905 23433 Negative_regulation MMP7 DHDDS 22303396 882209 Negative_regulation MMP7 ECM1 12011115 1283051 Negative_regulation MMP7 ECM2 12011115 1283052 Negative_regulation MMP7 EDN1 16503991 507446 Negative_regulation MMP7 EDNRB 25383546 3024195 Negative_regulation MMP7 ERVK-6 24455428 3151095 Negative_regulation MMP7 ETV1 21673681 436901 Negative_regulation MMP7 ETV1 23076342 2171039 Negative_regulation MMP7 ETV1 23076342 2171040 Negative_regulation MMP7 FAS 21912551 1144760 Negative_regulation MMP7 FASLG 7500022 1587163 Negative_regulation MMP7 FMR1 22685676 2002614 Negative_regulation MMP7 FN1 18001488 109388 Negative_regulation MMP7 FST 24667650 442723 Negative_regulation MMP7 FST 24667650 442732 Negative_regulation MMP7 FURIN 23936445 2830535 Negative_regulation MMP7 FURIN 23936445 2830736 Negative_regulation MMP7 GLRX 18560520 2390893 Negative_regulation MMP7 GLRX 18560520 2390983 Negative_regulation MMP7 GLRX 18560520 2391027 Negative_regulation MMP7 GLRX 18560520 2391071 Negative_regulation MMP7 GUCY2D 23940835 2236604 Negative_regulation MMP7 HDAC1 15899037 103593 Negative_regulation MMP7 HDAC1 24062615 1628613 Negative_regulation MMP7 HDAC2 15899037 103594 Negative_regulation MMP7 HDAC2 24062615 1628614 Negative_regulation MMP7 HPSE 19360105 2412778 Negative_regulation MMP7 HPSE 22590508 2640731 Negative_regulation MMP7 HPX 16542425 249206 Negative_regulation MMP7 IDO1 11375052 224783 Negative_regulation MMP7 IGF1 18513402 110928 Negative_regulation MMP7 IGF1 21637514 989538 Negative_regulation MMP7 IGF2 18513402 110929 Negative_regulation MMP7 IKBKB 22359588 2598149 Negative_regulation MMP7 IKBKG 22359588 2598150 Negative_regulation MMP7 IL10 24878845 2975488 Negative_regulation MMP7 IL1A 15535839 101931 Negative_regulation MMP7 IL2 20921282 1560596 Negative_regulation MMP7 IL33 23525523 1712120 Negative_regulation MMP7 INS 20828387 508196 Negative_regulation MMP7 ITGA2 21288331 855239 Negative_regulation MMP7 JAG1 20584780 1023265 Negative_regulation MMP7 JUN 20964825 855154 Negative_regulation MMP7 JUN 9888461 448018 Negative_regulation MMP7 LEF1 25178368 136748 Negative_regulation MMP7 LEP 24202338 497562 Negative_regulation MMP7 LPO 25505905 23434 Negative_regulation MMP7 LTB 12516548 2001359 Negative_regulation MMP7 MAPK1 21814482 1057475 Negative_regulation MMP7 MAPK10 21814482 1057476 Negative_regulation MMP7 MAPK11 21814482 1057477 Negative_regulation MMP7 MAPK12 21814482 1057478 Negative_regulation MMP7 MAPK13 21814482 1057479 Negative_regulation MMP7 MAPK14 21814482 1057480 Negative_regulation MMP7 MAPK15 21814482 1057474 Negative_regulation MMP7 MAPK3 21814482 1057481 Negative_regulation MMP7 MAPK4 21814482 1057482 Negative_regulation MMP7 MAPK6 21814482 1057483 Negative_regulation MMP7 MAPK7 21814482 1057484 Negative_regulation MMP7 MAPK8 21814482 1057485 Negative_regulation MMP7 MAPK9 21814482 1057486 Negative_regulation MMP7 MCS 23342045 2741813 Negative_regulation MMP7 MIR146B 23510696 3169353 Negative_regulation MMP7 MMP1 11027427 417866 Negative_regulation MMP7 MMP1 17286208 1639485 Negative_regulation MMP7 MMP1 24198787 962747 Negative_regulation MMP7 MMP1 24336522 1820055 Negative_regulation MMP7 MMP10 17286208 1639486 Negative_regulation MMP7 MMP10 24336522 1820056 Negative_regulation MMP7 MMP11 17286208 1639487 Negative_regulation MMP7 MMP11 24336522 1820057 Negative_regulation MMP7 MMP12 17286208 1639488 Negative_regulation MMP7 MMP12 17668061 2377400 Negative_regulation MMP7 MMP12 24336522 1820058 Negative_regulation MMP7 MMP13 17286208 1639489 Negative_regulation MMP7 MMP13 23226927 1751011 Negative_regulation MMP7 MMP13 24336522 1820059 Negative_regulation MMP7 MMP14 17286208 1639490 Negative_regulation MMP7 MMP14 24336522 1820060 Negative_regulation MMP7 MMP15 17286208 1639491 Negative_regulation MMP7 MMP15 24336522 1820061 Negative_regulation MMP7 MMP16 17286208 1639492 Negative_regulation MMP7 MMP16 24336522 1820062 Negative_regulation MMP7 MMP17 17286208 1639493 Negative_regulation MMP7 MMP17 24336522 1820063 Negative_regulation MMP7 MMP19 17286208 1639494 Negative_regulation MMP7 MMP19 17668061 2377401 Negative_regulation MMP7 MMP19 24336522 1820064 Negative_regulation MMP7 MMP2 17286208 1639495 Negative_regulation MMP7 MMP2 23638054 2787383 Negative_regulation MMP7 MMP2 23991045 2840722 Negative_regulation MMP7 MMP2 24336522 1820065 Negative_regulation MMP7 MMP2 25136829 2998966 Negative_regulation MMP7 MMP2 25580270 848539 Negative_regulation MMP7 MMP20 17286208 1639496 Negative_regulation MMP7 MMP20 24336522 1820066 Negative_regulation MMP7 MMP21 17286208 1639483 Negative_regulation MMP7 MMP21 24336522 1820053 Negative_regulation MMP7 MMP24 17286208 1639497 Negative_regulation MMP7 MMP24 24336522 1820067 Negative_regulation MMP7 MMP25 17286208 1639480 Negative_regulation MMP7 MMP25 24336522 1820050 Negative_regulation MMP7 MMP26 17286208 1639481 Negative_regulation MMP7 MMP26 24336522 1820051 Negative_regulation MMP7 MMP27 17286208 1639482 Negative_regulation MMP7 MMP27 24336522 1820052 Negative_regulation MMP7 MMP28 17286208 1639484 Negative_regulation MMP7 MMP28 24336522 1820054 Negative_regulation MMP7 MMP3 17286208 1639498 Negative_regulation MMP7 MMP3 17668061 2377402 Negative_regulation MMP7 MMP3 24336522 1820068 Negative_regulation MMP7 MMP7 17286208 1639499 Negative_regulation MMP7 MMP7 24336522 1820069 Negative_regulation MMP7 MMP8 17286208 1639500 Negative_regulation MMP7 MMP8 24336522 1820070 Negative_regulation MMP7 MMP9 17286208 1639501 Negative_regulation MMP7 MMP9 18288287 3072040 Negative_regulation MMP7 MMP9 22848429 2668938 Negative_regulation MMP7 MMP9 23570271 1836578 Negative_regulation MMP7 MMP9 23945132 1481430 Negative_regulation MMP7 MMP9 24198787 962748 Negative_regulation MMP7 MMP9 24228622 359331 Negative_regulation MMP7 MMP9 24336522 1820071 Negative_regulation MMP7 MOK 18511846 706154 Negative_regulation MMP7 MPST 23626836 2785032 Negative_regulation MMP7 MRC1 23937653 380331 Negative_regulation MMP7 MRC2 23937653 380330 Negative_regulation MMP7 MSLN 23694968 3135890 Negative_regulation MMP7 MSLN 23694968 3136002 Negative_regulation MMP7 MTOR PMC4212306 3206550 Negative_regulation MMP7 MUC16 23694968 3136001 Negative_regulation MMP7 MYLIP 24191129 737461 Negative_regulation MMP7 MYLIP 24885920 1874564 Negative_regulation MMP7 NEFH 20140245 2440161 Negative_regulation MMP7 NEFH 20140245 2440192 Negative_regulation MMP7 NOX1 23840100 1753600 Negative_regulation MMP7 NOX3 23840100 1753601 Negative_regulation MMP7 NOX4 23840100 1753602 Negative_regulation MMP7 NOX5 23840100 1753599 Negative_regulation MMP7 OPN1MW 22523714 1154746 Negative_regulation MMP7 PAEP 23185522 2721522 Negative_regulation MMP7 PCSK1 23936445 2830738 Negative_regulation MMP7 PCSK2 23936445 2830739 Negative_regulation MMP7 PCSK4 23936445 2830740 Negative_regulation MMP7 PCSK5 23936445 2830741 Negative_regulation MMP7 PCSK6 23936445 2830737 Negative_regulation MMP7 PCSK7 23936445 2830742 Negative_regulation MMP7 PCSK9 23936445 2830735 Negative_regulation MMP7 PDGFB 23226927 1751012 Negative_regulation MMP7 PIK3CA 23061721 533299 Negative_regulation MMP7 PIK3CA 25147440 1761390 Negative_regulation MMP7 PIK3R1 23061721 533300 Negative_regulation MMP7 PIK3R1 25147440 1761391 Negative_regulation MMP7 PIP 19765281 116735 Negative_regulation MMP7 PLOD2 20148173 2214699 Negative_regulation MMP7 PRDX2 22848731 2670245 Negative_regulation MMP7 PRG2 18205922 109905 Negative_regulation MMP7 PRG2 22529468 1047479 Negative_regulation MMP7 PRG3 18205922 109906 Negative_regulation MMP7 PRG3 22529468 1047480 Negative_regulation MMP7 PRG4 18205922 109907 Negative_regulation MMP7 PRG4 22529468 1047481 Negative_regulation MMP7 PROM1 25340937 1142799 Negative_regulation MMP7 PTGS2 16831226 249487 Negative_regulation MMP7 PTGS2 16959035 249725 Negative_regulation MMP7 PTGS2 23552603 2156178 Negative_regulation MMP7 RAD1 23840275 821084 Negative_regulation MMP7 RAD17 23840275 821085 Negative_regulation MMP7 RAD18 23840275 821083 Negative_regulation MMP7 RAD21 23840275 821086 Negative_regulation MMP7 RAD50 23840275 821087 Negative_regulation MMP7 RAD51 23840275 821088 Negative_regulation MMP7 RAD52 23840275 821089 Negative_regulation MMP7 RANBP9 23348590 559261 Negative_regulation MMP7 RANBP9 23348590 559285 Negative_regulation MMP7 RANBP9 23348590 559307 Negative_regulation MMP7 RBBP4 15899037 103595 Negative_regulation MMP7 RBBP4 24062615 1628615 Negative_regulation MMP7 RBBP7 15899037 103596 Negative_regulation MMP7 RBBP7 24062615 1628616 Negative_regulation MMP7 RECK 12100737 457390 Negative_regulation MMP7 RECK 18665171 430834 Negative_regulation MMP7 RECK 21731450 1091236 Negative_regulation MMP7 RECK 22048456 988728 Negative_regulation MMP7 RECK 22260435 263165 Negative_regulation MMP7 RECK 22260435 263166 Negative_regulation MMP7 RECK 22347664 1150692 Negative_regulation MMP7 RECK 22419890 1059931 Negative_regulation MMP7 RECK 23509776 180296 Negative_regulation MMP7 RECK 24376819 2902359 Negative_regulation MMP7 RECK 24765174 2168229 Negative_regulation MMP7 RECK 24891760 1759187 Negative_regulation MMP7 REG1A 23690852 819177 Negative_regulation MMP7 RHOA 20843370 1504523 Negative_regulation MMP7 RNF146 24454854 2910160 Negative_regulation MMP7 S100A4 23922901 2827437 Negative_regulation MMP7 SDF2 23442825 87636 Negative_regulation MMP7 SDF4 23442825 87637 Negative_regulation MMP7 SERPINE1 23724005 2798879 Negative_regulation MMP7 SFN 23662110 818743 Negative_regulation MMP7 SFN 23983046 135655 Negative_regulation MMP7 SFN 23983046 135695 Negative_regulation MMP7 SIRT1 20920189 3111351 Negative_regulation MMP7 SLC12A9 24523890 2921872 Negative_regulation MMP7 SLC22A3 20584780 1023277 Negative_regulation MMP7 SLC25A1 24471092 3077373 Negative_regulation MMP7 SLC25A27 22427795 2610140 Negative_regulation MMP7 SLC39A4 23857777 781403 Negative_regulation MMP7 SLC9A1 PMC2756345 496273 Negative_regulation MMP7 SPOCK1 18205922 109845 Negative_regulation MMP7 SRR 22629429 2646471 Negative_regulation MMP7 SSFA2 7537277 1436574 Negative_regulation MMP7 SSFA2 7537277 1436663 Negative_regulation MMP7 SSFA2 7537277 1436685 Negative_regulation MMP7 TGFB1I1 24811612 1159537 Negative_regulation MMP7 TGFB1I1 24811612 1159538 Negative_regulation MMP7 TGFBRAP1 17638420 2263225 Negative_regulation MMP7 TIMP1 10459021 1249160 Negative_regulation MMP7 TIMP1 12718745 99727 Negative_regulation MMP7 TIMP1 12718745 99753 Negative_regulation MMP7 TIMP1 12975354 1297248 Negative_regulation MMP7 TIMP1 15642138 102359 Negative_regulation MMP7 TIMP1 15701164 480166 Negative_regulation MMP7 TIMP1 16478544 365204 Negative_regulation MMP7 TIMP1 16880790 427893 Negative_regulation MMP7 TIMP1 17668061 2377399 Negative_regulation MMP7 TIMP1 17980029 461778 Negative_regulation MMP7 TIMP1 19390643 1909188 Negative_regulation MMP7 TIMP1 19479048 2417533 Negative_regulation MMP7 TIMP1 19961576 854786 Negative_regulation MMP7 TIMP1 20148173 2214698 Negative_regulation MMP7 TIMP1 20169175 2001855 Negative_regulation MMP7 TIMP1 20540791 1855772 Negative_regulation MMP7 TIMP1 21092330 481805 Negative_regulation MMP7 TIMP1 21711826 519349 Negative_regulation MMP7 TIMP1 21923935 514849 Negative_regulation MMP7 TIMP1 22078297 1008891 Negative_regulation MMP7 TIMP1 22528051 615996 Negative_regulation MMP7 TIMP1 22701711 2652126 Negative_regulation MMP7 TIMP1 22739984 556152 Negative_regulation MMP7 TIMP1 22937143 2683100 Negative_regulation MMP7 TIMP1 23018346 1735691 Negative_regulation MMP7 TIMP1 23185522 2721521 Negative_regulation MMP7 TIMP1 23750094 163620 Negative_regulation MMP7 TIMP1 23786632 1666793 Negative_regulation MMP7 TIMP1 23829630 294517 Negative_regulation MMP7 TIMP1 23873298 1108841 Negative_regulation MMP7 TIMP1 23986797 83162 Negative_regulation MMP7 TIMP1 24137341 2165541 Negative_regulation MMP7 TIMP1 24156369 138903 Negative_regulation MMP7 TIMP1 24156369 138925 Negative_regulation MMP7 TIMP1 24278882 1498586 Negative_regulation MMP7 TIMP1 24330623 270988 Negative_regulation MMP7 TIMP1 24475101 2914818 Negative_regulation MMP7 TIMP1 24616631 3156118 Negative_regulation MMP7 TIMP1 24616654 3156146 Negative_regulation MMP7 TIMP1 24675764 2372527 Negative_regulation MMP7 TIMP1 24733017 2952412 Negative_regulation MMP7 TIMP1 25107295 647595 Negative_regulation MMP7 TIMP1 25121738 2997279 Negative_regulation MMP7 TIMP1 25205985 90212 Negative_regulation MMP7 TIMP1 25557794 1605961 Negative_regulation MMP7 TIMP2 10682680 416319 Negative_regulation MMP7 TIMP2 10851027 1259225 Negative_regulation MMP7 TIMP2 12427868 1287878 Negative_regulation MMP7 TIMP2 17179989 428422 Negative_regulation MMP7 TIMP2 21349159 3206969 Negative_regulation MMP7 TIMP2 22048456 988729 Negative_regulation MMP7 TIMP2 22318811 3232885 Negative_regulation MMP7 TIMP2 22739984 556153 Negative_regulation MMP7 TIMP2 23300891 2737208 Negative_regulation MMP7 TIMP2 23598418 1105962 Negative_regulation MMP7 TIMP2 23894327 2824158 Negative_regulation MMP7 TIMP2 23970935 822418 Negative_regulation MMP7 TIMP2 23991045 2840721 Negative_regulation MMP7 TIMP2 24137341 2165542 Negative_regulation MMP7 TIMP2 24231999 1137912 Negative_regulation MMP7 TIMP2 24376839 2902423 Negative_regulation MMP7 TIMP2 24520285 2167612 Negative_regulation MMP7 TIMP2 25329658 3016265 Negative_regulation MMP7 TIMP3 20498843 2451100 Negative_regulation MMP7 TIMP3 21349159 3206970 Negative_regulation MMP7 TIMP3 22739984 556154 Negative_regulation MMP7 TIMP3 23509776 180297 Negative_regulation MMP7 TIMP3 24191129 737460 Negative_regulation MMP7 TIMP4 24733017 2952413 Negative_regulation MMP7 TIMP4 25114377 1760381 Negative_regulation MMP7 TLR9 24959259 2168958 Negative_regulation MMP7 TMED7 24690323 540190 Negative_regulation MMP7 TNF 19889233 3097658 Negative_regulation MMP7 TNF 22675496 2649009 Negative_regulation MMP7 TP53 24690323 540189 Negative_regulation MMP7 TSPAN1 10491398 1250252 Negative_regulation MMP7 TSPAN1 23840773 2816828 Negative_regulation MMP7 TSPAN10 10491398 1250261 Negative_regulation MMP7 TSPAN10 23840773 2816837 Negative_regulation MMP7 TSPAN11 10491398 1250263 Negative_regulation MMP7 TSPAN11 23840773 2816839 Negative_regulation MMP7 TSPAN12 10491398 1250256 Negative_regulation MMP7 TSPAN12 23840773 2816832 Negative_regulation MMP7 TSPAN13 10491398 1250257 Negative_regulation MMP7 TSPAN13 23840773 2816833 Negative_regulation MMP7 TSPAN14 10491398 1250259 Negative_regulation MMP7 TSPAN14 23840773 2816835 Negative_regulation MMP7 TSPAN15 10491398 1250258 Negative_regulation MMP7 TSPAN15 23840773 2816834 Negative_regulation MMP7 TSPAN16 10491398 1250262 Negative_regulation MMP7 TSPAN16 23840773 2816838 Negative_regulation MMP7 TSPAN17 10491398 1250249 Negative_regulation MMP7 TSPAN17 23840773 2816825 Negative_regulation MMP7 TSPAN18 10491398 1250254 Negative_regulation MMP7 TSPAN18 23840773 2816830 Negative_regulation MMP7 TSPAN19 10491398 1250264 Negative_regulation MMP7 TSPAN19 23840773 2816840 Negative_regulation MMP7 TSPAN2 10491398 1250253 Negative_regulation MMP7 TSPAN2 23840773 2816829 Negative_regulation MMP7 TSPAN3 10491398 1250250 Negative_regulation MMP7 TSPAN3 23840773 2816826 Negative_regulation MMP7 TSPAN31 10491398 1250243 Negative_regulation MMP7 TSPAN31 23840773 2816819 Negative_regulation MMP7 TSPAN32 10491398 1250248 Negative_regulation MMP7 TSPAN32 23840773 2816824 Negative_regulation MMP7 TSPAN33 10491398 1250260 Negative_regulation MMP7 TSPAN33 23840773 2816836 Negative_regulation MMP7 TSPAN4 10491398 1250247 Negative_regulation MMP7 TSPAN4 23840773 2816823 Negative_regulation MMP7 TSPAN5 10491398 1250251 Negative_regulation MMP7 TSPAN5 23840773 2816827 Negative_regulation MMP7 TSPAN6 10491398 1250246 Negative_regulation MMP7 TSPAN6 23840773 2816822 Negative_regulation MMP7 TSPAN7 10491398 1250244 Negative_regulation MMP7 TSPAN7 23840773 2816820 Negative_regulation MMP7 TSPAN8 10491398 1250245 Negative_regulation MMP7 TSPAN8 23840773 2816821 Negative_regulation MMP7 TSPAN9 10491398 1250255 Negative_regulation MMP7 TSPAN9 23840773 2816831 Negative_regulation MMP7 TYR 24243820 2185492 Negative_regulation MMP7 UCP2 17472436 2262968 Negative_regulation MMP7 VEGFA 22056617 13861 Negative_regulation MMP7 VEGFA 22848429 2668937 Negative_regulation MMP7 WNK1 22359588 2598147 Negative_regulation MMP7 WNK1 24238405 129956 Negative_regulation MMP7 ZBTB33 24856827 222922 Negative_regulation MMP8 FAS 21912551 1144761 Negative_regulation MMP8 MMP7 17286208 1639502 Negative_regulation MMP8 PCSK9 23936445 2830743 Negative_regulation MMP8 TNF 19889233 3097659 Negative_regulation MMP8 TNF 22675496 2649011 Negative_regulation MMP8 TSPAN1 10491398 1250274 Negative_regulation MMP8 TSPAN1 23840773 2816850 Negative_regulation MMP9 ARSA 20137092 1722980 Negative_regulation MMP9 ARSA 20137092 1722981 Negative_regulation MMP9 ARSA 20137092 1722982 Negative_regulation MMP9 ARSA 20137092 1722985 Negative_regulation MMP9 CCND1 23383271 2749839 Negative_regulation MMP9 CHI3L1 21991364 2561589 Negative_regulation MMP9 CHI3L1 24399973 963263 Negative_regulation MMP9 EPHB2 22413009 2610075 Negative_regulation MMP9 EPHB2 23710144 3154645 Negative_regulation MMP9 EPHB2 24504172 2187101 Negative_regulation MMP9 EPHB2 25499743 476668 Negative_regulation MMP9 F2R 22992722 988756 Negative_regulation MMP9 F2R 23565108 935336 Negative_regulation MMP9 FAS 21912551 1144762 Negative_regulation MMP9 ID1 23714001 1699832 Negative_regulation MMP9 LBP 22438957 2612189 Negative_regulation MMP9 MAP2K6 12177807 421994 Negative_regulation MMP9 MAP2K6 19852815 326849 Negative_regulation MMP9 MMP28 18288287 3072046 Negative_regulation MMP9 MMP28 19664212 116336 Negative_regulation MMP9 MMP28 22848429 2668946 Negative_regulation MMP9 MMP28 23570271 1836584 Negative_regulation MMP9 MMP28 23800102 2111888 Negative_regulation MMP9 MMP28 24198787 962755 Negative_regulation MMP9 MMP7 17286208 1639503 Negative_regulation MMP9 MMP7 18288287 3072061 Negative_regulation MMP9 MMP7 19664212 116351 Negative_regulation MMP9 MMP7 22848429 2668961 Negative_regulation MMP9 MMP7 23570271 1836599 Negative_regulation MMP9 MMP7 23800102 2111903 Negative_regulation MMP9 MMP7 24198787 962770 Negative_regulation MMP9 PCSK9 23936445 2830751 Negative_regulation MMP9 PLAU 25222667 1730973 Negative_regulation MMP9 TLR7 23940584 2831856 Negative_regulation MMP9 TNF 19889233 3097660 Negative_regulation MMP9 TNF 22069489 2569240 Negative_regulation MMP9 TNF 22675496 2649013 Negative_regulation MMP9 TNF 22761606 3075864 Negative_regulation MMP9 TNF 23554800 1226275 Negative_regulation MMP9 TNF 23587438 1666160 Negative_regulation MMP9 TNF 23587438 1666507 Negative_regulation MMP9 TNF 24861337 653716 Negative_regulation MMP9 TNF 9743290 447878 Negative_regulation MMP9 TNF 9743290 447879 Negative_regulation MMP9 TNF 9743290 447880 Negative_regulation MMP9 TNF 9743290 447881 Negative_regulation MMP9 TNFSF10 21209944 2492518 Negative_regulation MMP9 TNFSF10 21209944 2492520 Negative_regulation MMP9 TSPAN1 10491398 1250296 Negative_regulation MMP9 TSPAN1 23840773 2816872 Negative_regulation MNAT1 MAP2K6 18282094 3040979 Negative_regulation MOCOS CCL17 24956472 2983096 Negative_regulation MOK CLU PMC4184146 2236346 Negative_regulation MOK EPHB2 24084731 1113176 Negative_regulation MOK ITGB2 21347371 2503707 Negative_regulation MOK S100B 20827311 512997 Negative_regulation MOK TNF 21749686 123219 Negative_regulation MOK TNF 24386004 825054 Negative_regulation MOS ITGB2 19175917 352564 Negative_regulation MPO ARSA 18475455 1743793 Negative_regulation MPO ARSA 18475455 1743814 Negative_regulation MPO ARSA 25045574 1083004 Negative_regulation MPO TNF 21232147 508360 Negative_regulation MPO TNF 23573127 818413 Negative_regulation MPP1 TNF 8691130 1598114 Negative_regulation MRC1 TNF 23937653 380290 Negative_regulation MRC2 TNF 23937653 380288 Negative_regulation MRE11A CAPN8 23056924 140371 Negative_regulation MSC IL1B 25562599 3037245 Negative_regulation MSC TNF 24391353 1756479 Negative_regulation MSC TNF 24614867 2933160 Negative_regulation MSH2 FAS 11641530 1632782 Negative_regulation MSH3 ABCG2 25330312 2373105 Negative_regulation MSH3 FAS 11641530 1632783 Negative_regulation MSH3 MAP2K6 23320839 482755 Negative_regulation MSH3 MAP2K6 23320839 482756 Negative_regulation MSH3 SRGN 19718041 1931089 Negative_regulation MSH4 FAS 11641530 1632784 Negative_regulation MSH5 FAS 11641530 1632785 Negative_regulation MSH6 FAS 11641530 1632786 Negative_regulation MSLN MUC16 17067392 1845707 Negative_regulation MSLN TNF 21880146 1863105 Negative_regulation MSN EPHB2 25406076 3028328 Negative_regulation MSTN PGC 23180446 1239159 Negative_regulation MSTN PGC 23665154 1054169 Negative_regulation MSX1 AMH 16968133 2261904 Negative_regulation MSX1 BARX1 23531410 399203 Negative_regulation MSX1 BMP1 22140629 3086064 Negative_regulation MSX1 BMP1 23382810 2746299 Negative_regulation MSX1 BMP10 22140629 3086072 Negative_regulation MSX1 BMP10 23382810 2746307 Negative_regulation MSX1 BMP15 22140629 3086065 Negative_regulation MSX1 BMP15 23382810 2746300 Negative_regulation MSX1 BMP2 20942943 1696792 Negative_regulation MSX1 BMP2 22140629 3086066 Negative_regulation MSX1 BMP2 23382810 2746301 Negative_regulation MSX1 BMP3 22140629 3086067 Negative_regulation MSX1 BMP3 23382810 2746302 Negative_regulation MSX1 BMP4 19266065 1055494 Negative_regulation MSX1 BMP4 22140629 3086068 Negative_regulation MSX1 BMP4 23382810 2746303 Negative_regulation MSX1 BMP4 24550718 2299730 Negative_regulation MSX1 BMP5 22140629 3086069 Negative_regulation MSX1 BMP5 23382810 2746304 Negative_regulation MSX1 BMP6 22140629 3086070 Negative_regulation MSX1 BMP6 23382810 2746305 Negative_regulation MSX1 BMP7 22140629 3086071 Negative_regulation MSX1 BMP7 23382810 2746306 Negative_regulation MSX1 BMPR1A 23316168 960746 Negative_regulation MSX1 DLX2 16157866 2017600 Negative_regulation MSX1 FGF2 24550718 2299731 Negative_regulation MSX1 FGF2 24550718 2300070 Negative_regulation MSX1 FGFR1 24550718 2300071 Negative_regulation MSX1 FGFR2 24550718 2300072 Negative_regulation MSX1 FGFR3 24550718 2300073 Negative_regulation MSX1 FGFR4 24550718 2300074 Negative_regulation MSX1 GYS1 21433221 3171435 Negative_regulation MSX1 GYS2 21433221 3171436 Negative_regulation MSX1 HOXB1 21433221 3171378 Negative_regulation MSX1 HOXB1 21433221 3171401 Negative_regulation MSX1 LMX1A 23789101 169762 Negative_regulation MSX1 MEF2C 23280066 409340 Negative_regulation MSX1 MEF2C 23280066 409347 Negative_regulation MSX1 MSX1 23383281 2750054 Negative_regulation MSX1 MSX2 23383281 2750055 Negative_regulation MSX1 SHH 17848995 2378067 Negative_regulation MSX1 SHOX2 23776616 2805041 Negative_regulation MSX1 SMAD1 22140629 3086073 Negative_regulation MSX1 SMAD1 22140629 3086074 Negative_regulation MSX1 SMAD2 22140629 3086075 Negative_regulation MSX1 SMAD2 22140629 3086076 Negative_regulation MSX1 SMAD3 22140629 3086077 Negative_regulation MSX1 SMAD3 22140629 3086078 Negative_regulation MSX1 SMAD4 22140629 3086079 Negative_regulation MSX1 SMAD4 22140629 3086080 Negative_regulation MSX1 SMAD5 22140629 3086081 Negative_regulation MSX1 SMAD5 22140629 3086082 Negative_regulation MSX1 SMAD6 22140629 3086083 Negative_regulation MSX1 SMAD6 22140629 3086084 Negative_regulation MSX1 SMAD7 22140629 3086085 Negative_regulation MSX1 SMAD7 22140629 3086086 Negative_regulation MSX1 SMAD9 22140629 3086087 Negative_regulation MSX1 SMAD9 22140629 3086088 Negative_regulation MSX1 WNT1 23789101 169761 Negative_regulation MSX1 WNT2 23383281 2750052 Negative_regulation MSX1 WNT7B 23383281 2750053 Negative_regulation MSX2 MSX1 23383281 2750058 Negative_regulation MT1H MAP2K6 25344914 2205988 Negative_regulation MT2A CCND1 23870553 1700165 Negative_regulation MTA1 CLDN10 23752226 1572433 Negative_regulation MTOR EPHB2 20860815 1859240 Negative_regulation MTOR EPHB2 21484200 1652966 Negative_regulation MTOR EPHB2 22159814 1140705 Negative_regulation MTOR EPHB2 23077579 2704794 Negative_regulation MTOR EPHB2 23077579 2704809 Negative_regulation MTOR EPHB2 24212825 498988 Negative_regulation MTOR EPHB2 24303063 2887901 Negative_regulation MTOR EPHB2 24710474 618140 Negative_regulation MTOR EPHB2 24714637 2950113 Negative_regulation MTOR FAS 18776140 706722 Negative_regulation MTOR FAS 18776140 706726 Negative_regulation MTOR FBXO32 24765525 847698 Negative_regulation MTOR FOLR1 20069122 1671638 Negative_regulation MTOR FOXO1 22476916 1238842 Negative_regulation MTOR FOXO1 22870349 696223 Negative_regulation MTOR FOXO1 22870349 696320 Negative_regulation MTOR FOXO1 23028409 2219969 Negative_regulation MTOR FOXO1 23614736 829992 Negative_regulation MTOR FOXO1 23614736 830019 Negative_regulation MTOR FOXO1 23800068 830094 Negative_regulation MTOR FOXO1 23800068 830183 Negative_regulation MTOR FOXO1 23800068 830184 Negative_regulation MTOR FOXO1 23800068 830217 Negative_regulation MTOR FOXO1 24454908 2910309 Negative_regulation MTOR INPP4B 25126743 2998001 Negative_regulation MTOR MAP2K6 21484200 1652972 Negative_regulation MTOR MAP2K6 22401294 263956 Negative_regulation MTOR MAP2K6 22808163 2664887 Negative_regulation MTOR MAP2K6 23242584 477371 Negative_regulation MTOR MAP2K6 23676467 2183296 Negative_regulation MTOR MAP2K6 24212825 498994 Negative_regulation MTOR MAP2K6 24367624 2900388 Negative_regulation MTOR RIC3 18591430 1353357 Negative_regulation MTOR RIC3 18591430 1353360 Negative_regulation MTOR STK39 20835268 11876 Negative_regulation MTOR STK39 23788913 657420 Negative_regulation MTOR TCN1 20489726 546936 Negative_regulation MTTER RNASE1 19906695 2048252 Negative_regulation MTTER RNASE7 19906695 2048260 Negative_regulation MUC1 AGR2 22945649 2148400 Negative_regulation MUC1 EPHB2 19503797 2418212 Negative_regulation MUC1 FOXQ1 25356753 2206484 Negative_regulation MUC1 RAB31 22792175 2661061 Negative_regulation MUC1 RAB31 22792175 2661079 Negative_regulation MUC1 RAB31 25472813 1486012 Negative_regulation MUC1 S100A7 23300877 2736920 Negative_regulation MUC1 TNF 22577246 1749707 Negative_regulation MUC1 TNF 22577246 1749833 Negative_regulation MUC1 TNF 23864879 638053 Negative_regulation MUC1 TNF 25125479 412867 Negative_regulation MUC12 EPHB2 19503797 2418213 Negative_regulation MUC12 TNF 22577246 1749709 Negative_regulation MUC12 TNF 22577246 1749835 Negative_regulation MUC13 EPHB2 19503797 2418214 Negative_regulation MUC13 TNF 22577246 1749711 Negative_regulation MUC13 TNF 22577246 1749837 Negative_regulation MUC15 EPHB2 19503797 2418206 Negative_regulation MUC15 TNF 22577246 1749695 Negative_regulation MUC15 TNF 22577246 1749821 Negative_regulation MUC16 AHR 19996156 811667 Negative_regulation MUC16 ATOH1 22719768 1143440 Negative_regulation MUC16 BMPR1B 24339876 2891323 Negative_regulation MUC16 BMPR1B 24339876 2891331 Negative_regulation MUC16 BMPR1B 24339876 2891468 Negative_regulation MUC16 CA2 11004201 1607049 Negative_regulation MUC16 CA2 21283816 2498377 Negative_regulation MUC16 CA2 25197168 1761984 Negative_regulation MUC16 CARD11 22303480 2595076 Negative_regulation MUC16 CLCA3P 22438829 2333789 Negative_regulation MUC16 EPHB2 19503797 2418207 Negative_regulation MUC16 GNAS 23403822 440209 Negative_regulation MUC16 HSPG2 22013477 695843 Negative_regulation MUC16 IL12A 22606349 2643346 Negative_regulation MUC16 IL12B 22606349 2643347 Negative_regulation MUC16 IL13 23283176 3225421 Negative_regulation MUC16 IL37 25375146 3070103 Negative_regulation MUC16 IL4 16551361 3106982 Negative_regulation MUC16 MAPK1 22977714 646586 Negative_regulation MUC16 MAPK10 22977714 646587 Negative_regulation MUC16 MAPK11 22977714 646588 Negative_regulation MUC16 MAPK12 22977714 646589 Negative_regulation MUC16 MAPK13 22977714 646590 Negative_regulation MUC16 MAPK14 22977714 646591 Negative_regulation MUC16 MAPK15 22977714 646585 Negative_regulation MUC16 MAPK3 22977714 646592 Negative_regulation MUC16 MAPK4 22977714 646593 Negative_regulation MUC16 MAPK6 22977714 646594 Negative_regulation MUC16 MAPK7 22977714 646595 Negative_regulation MUC16 MAPK8 22977714 646596 Negative_regulation MUC16 MAPK9 22977714 646597 Negative_regulation MUC16 MECOM 17029558 2303317 Negative_regulation MUC16 MUC1 24212946 499247 Negative_regulation MUC16 MUC5AC 20209152 2370672 Negative_regulation MUC16 MUC5AC 22577246 1749698 Negative_regulation MUC16 MUC5AC 22577246 1749791 Negative_regulation MUC16 MUC5AC 22577246 1749824 Negative_regulation MUC16 MYLIP 24204560 2872936 Negative_regulation MUC16 NKX2-1 23320163 3086813 Negative_regulation MUC16 NLRP6 24886810 1127317 Negative_regulation MUC16 NM 21785567 1222327 Negative_regulation MUC16 NOS1 9400742 797450 Negative_regulation MUC16 NOS2 9400742 797451 Negative_regulation MUC16 NOS3 9400742 797452 Negative_regulation MUC16 NPS 22355725 3130376 Negative_regulation MUC16 PPARA 18053220 3108706 Negative_regulation MUC16 PTGS2 22013477 695844 Negative_regulation MUC16 RABEPK 22606349 2643345 Negative_regulation MUC16 SNAP23 23162705 3184245 Negative_regulation MUC16 SPDEF 21203431 2490167 Negative_regulation MUC16 STAT6 21203431 2490166 Negative_regulation MUC16 TGFB1 15203548 1739522 Negative_regulation MUC16 TNF 22577246 1749697 Negative_regulation MUC16 TNF 22577246 1749823 Negative_regulation MUC16 TRPM5 23741618 749215 Negative_regulation MUC17 EPHB2 19503797 2418208 Negative_regulation MUC17 TNF 22577246 1749699 Negative_regulation MUC17 TNF 22577246 1749825 Negative_regulation MUC19 EPHB2 19503797 2418205 Negative_regulation MUC19 TNF 22577246 1749693 Negative_regulation MUC19 TNF 22577246 1749819 Negative_regulation MUC2 EPHB2 19503797 2418215 Negative_regulation MUC2 TNF 22577246 1749713 Negative_regulation MUC2 TNF 22577246 1749839 Negative_regulation MUC20 EPHB2 19503797 2418210 Negative_regulation MUC20 TNF 22577246 1749703 Negative_regulation MUC20 TNF 22577246 1749829 Negative_regulation MUC21 EPHB2 19503797 2418209 Negative_regulation MUC21 TNF 22577246 1749701 Negative_regulation MUC21 TNF 22577246 1749827 Negative_regulation MUC22 EPHB2 19503797 2418211 Negative_regulation MUC22 TNF 22577246 1749705 Negative_regulation MUC22 TNF 22577246 1749831 Negative_regulation MUC4 EPHB2 19503797 2418216 Negative_regulation MUC4 TNF 22577246 1749715 Negative_regulation MUC4 TNF 22577246 1749841 Negative_regulation MUC5AC EPHB2 23549814 3233597 Negative_regulation MUC5AC MUC16 20209152 2370684 Negative_regulation MUC5AC MUC16 22577246 1749719 Negative_regulation MUC5AC MUC16 22577246 1749803 Negative_regulation MUC5AC MUC16 22577246 1749845 Negative_regulation MUC5AC MUC16 24905583 2977357 Negative_regulation MUC5AC TNF 25398130 3027509 Negative_regulation MUC6 EPHB2 19503797 2418217 Negative_regulation MUC6 TNF 22577246 1749732 Negative_regulation MUC6 TNF 22577246 1749858 Negative_regulation MUC7 EPHB2 19503797 2418218 Negative_regulation MUC7 TNF 22577246 1749734 Negative_regulation MUC7 TNF 22577246 1749860 Negative_regulation MUC8 EPHB2 19503797 2418219 Negative_regulation MUC8 TNF 22577246 1749736 Negative_regulation MUC8 TNF 22577246 1749862 Negative_regulation MUSK PGC 24472348 1727106 Negative_regulation MX1 MX2 23384108 3101786 Negative_regulation MYC AXIN2 19262462 764066 Negative_regulation MYC EPHB2 15811177 1844544 Negative_regulation MYC EPHB2 16899113 1845530 Negative_regulation MYC EPHB2 24550252 752868 Negative_regulation MYC FHL1 24952875 274081 Negative_regulation MYC FHL1 24952875 274098 Negative_regulation MYC FOXO1 20604938 329306 Negative_regulation MYC FOXO1 20604938 329360 Negative_regulation MYC FOXO1 21835778 2065742 Negative_regulation MYC FOXO1 24672772 947572 Negative_regulation MYC FOXO1 24977668 2194653 Negative_regulation MYC IFI27 19707334 175473 Negative_regulation MYC MAP2K6 24550252 752874 Negative_regulation MYC NES 21304179 2174840 Negative_regulation MYC RNASE1 11734062 368689 Negative_regulation MYC RNASE7 11734062 368697 Negative_regulation MYCN NES 20651942 2174223 Negative_regulation MYH1 PGC 25136584 197217 Negative_regulation MYH16 CLN3 25353002 1888755 Negative_regulation MYH16 CNBP 21232131 1007517 Negative_regulation MYH16 EED 22771996 3187775 Negative_regulation MYH16 EZH2 22771996 3187776 Negative_regulation MYH16 HDAC1 22771996 3187777 Negative_regulation MYH16 HDAC2 22771996 3187778 Negative_regulation MYH16 ILK 10953009 1262057 Negative_regulation MYH16 INHBA 22621320 150620 Negative_regulation MYH16 INHBA 22621320 150657 Negative_regulation MYH16 MSTN 22621320 150656 Negative_regulation MYH16 RBBP4 22771996 3187779 Negative_regulation MYH16 RBBP7 22771996 3187780 Negative_regulation MYH16 SIX1 24852826 2359295 Negative_regulation MYH16 SUZ12 22771996 3187774 Negative_regulation MYH16 TRIM63 23024748 2689690 Negative_regulation MYH16 USP19 24595460 1239263 Negative_regulation MYH16 YY1 19906305 465062 Negative_regulation MYH16 YY1 22771996 3187773 Negative_regulation MYH2 TNF 24453411 1756651 Negative_regulation MYH2 TNF 24453411 1756652 Negative_regulation MYH2 TNF 24453411 1756658 Negative_regulation MYH3 CLN3 25353002 1888762 Negative_regulation MYH3 CNBP 21232131 1007524 Negative_regulation MYH3 EED 22771996 3187831 Negative_regulation MYH3 EZH2 22771996 3187832 Negative_regulation MYH3 HDAC1 22771996 3187833 Negative_regulation MYH3 HDAC2 22771996 3187834 Negative_regulation MYH3 ILK 10953009 1262064 Negative_regulation MYH3 INHBA 22621320 150627 Negative_regulation MYH3 INHBA 22621320 150671 Negative_regulation MYH3 MSTN 22621320 150670 Negative_regulation MYH3 RBBP4 22771996 3187835 Negative_regulation MYH3 RBBP7 22771996 3187836 Negative_regulation MYH3 SIX1 24852826 2359302 Negative_regulation MYH3 SUZ12 22771996 3187830 Negative_regulation MYH3 TRIM63 23024748 2689697 Negative_regulation MYH3 USP19 24595460 1239270 Negative_regulation MYH3 YY1 19906305 465069 Negative_regulation MYH3 YY1 22771996 3187829 Negative_regulation MYL1 OXTR 23948067 3102066 Negative_regulation MYL10 OXTR 23948067 3102052 Negative_regulation MYL2 OXTR 23948067 3102069 Negative_regulation MYL3 OXTR 23948067 3102072 Negative_regulation MYL4 OXTR 23948067 3102075 Negative_regulation MYL5 OXTR 23948067 3102078 Negative_regulation MYL6 OXTR 23948067 3102081 Negative_regulation MYL7 OXTR 23948067 3102049 Negative_regulation MYL9 OXTR 23948067 3102046 Negative_regulation MYLIP CCND1 19881910 672082 Negative_regulation MYLIP CCND1 23383271 2749848 Negative_regulation MYLIP CCND1 24991193 484738 Negative_regulation MYLIP CCND1 25132913 2229845 Negative_regulation MYLIP CDKN1C 21278784 12431 Negative_regulation MYLIP CHI3L1 25358394 1946496 Negative_regulation MYLIP CLU 25038756 496515 Negative_regulation MYLIP CTGF 23681229 561788 Negative_regulation MYLIP CTGF 25003330 2195004 Negative_regulation MYLIP EPHB2 20041145 2435473 Negative_regulation MYLIP EPHB2 22367739 778313 Negative_regulation MYLIP EPHB2 23469214 2763254 Negative_regulation MYLIP EPHB2 23552555 2155912 Negative_regulation MYLIP EPHB2 23633945 3060718 Negative_regulation MYLIP EPHB2 25275294 2202504 Negative_regulation MYLIP FAS 23166734 2718819 Negative_regulation MYLIP FAS 23166734 2718827 Negative_regulation MYLIP FHL1 25272045 3011958 Negative_regulation MYLIP FOXO1 23029264 2695767 Negative_regulation MYLIP IFI27 24727437 2188811 Negative_regulation MYLIP JAG1 21887253 2548195 Negative_regulation MYLIP JAG1 22629283 882495 Negative_regulation MYLIP MAP2K6 23552555 2155918 Negative_regulation MYLIP PLAU 23864708 1816981 Negative_regulation MYLIP PLAU 23864708 1817002 Negative_regulation MYLIP S100B 21709278 719554 Negative_regulation MYLIP TLR7 20041145 2435392 Negative_regulation MYLIP TLR7 22992343 1866872 Negative_regulation MYLIP TNF 21611196 2523832 Negative_regulation MYLIP TNF 23739951 605900 Negative_regulation MYLIP TNF 24113581 1113263 Negative_regulation MYLIP TNF 24885472 1701858 Negative_regulation MYLIP TNF 25175907 3114875 Negative_regulation MYLIP TNF 25175907 3114882 Negative_regulation MYLIP TNF 25268390 986563 Negative_regulation MYLIP TP63 24396276 679780 Negative_regulation MYLIP TP63 24457968 571687 Negative_regulation MYLIP WNT7A 23862015 170020 Negative_regulation MYLK TNF 21731751 2532421 Negative_regulation MYO10 EPHB2 24282625 2887141 Negative_regulation MYO16 EPHB2 24282625 2887140 Negative_regulation MYO19 EPHB2 24282625 2887139 Negative_regulation MYO5B TF 18687135 281662 Negative_regulation MYO6 EPHB2 24282625 2887142 Negative_regulation MYOC GPR115 24367514 2899949 Negative_regulation MYOC GPR132 24367514 2899938 Negative_regulation MYOC GPR87 24367514 2900018 Negative_regulation MYOCD EPHB2 20446923 651375 Negative_regulation MYOCD EPHB2 23855625 1232420 Negative_regulation MYOCD FOXO1 23554919 2773864 Negative_regulation MYOCD MAP2K6 23554919 2774018 Negative_regulation MYOCD TNF 25384061 3024729 Negative_regulation MYOG CCND1 8896599 1456863 Negative_regulation MYOG FOXO1 24551104 2923014 Negative_regulation MYOG FOXO1 24577092 572591 Negative_regulation NAALADL1 TNFSF10 24155891 2871138 Negative_regulation NAMPT TNF 21542902 1229079 Negative_regulation NANOG EPHB2 21194951 665997 Negative_regulation NANOG EPHB2 24643025 2935522 Negative_regulation NANOG EPHB2 24643025 2935523 Negative_regulation NANOG EPHB2 24643025 2935538 Negative_regulation NANOG ZFP57 24550733 2356356 Negative_regulation NANOS2 TNF 22022590 2563983 Negative_regulation NANOS3 TNF 24391884 2904797 Negative_regulation NAV1 FOXO1 22400069 2608769 Negative_regulation NAV1 FOXO1 22400069 2608774 Negative_regulation NAV1 FOXO1 22400069 2608784 Negative_regulation NAV1 FOXO1 22400069 2608791 Negative_regulation NBL1 TNF 7520469 1589450 Negative_regulation NCF1 TNF 21167936 857660 Negative_regulation NCOA3 MATN2 24691449 2947768 Negative_regulation NDOR1 MMP28 18629001 2392935 Negative_regulation NDOR1 MMP7 18629001 2392950 Negative_regulation NEDD9 ANAPC10 15144564 277496 Negative_regulation NEDD9 ANAPC10 15144564 277497 Negative_regulation NEDD9 ANAPC10 15144564 277528 Negative_regulation NEDD9 ANAPC10 15144564 277572 Negative_regulation NEDD9 APC 15144564 277551 Negative_regulation NEDD9 CDH1 15144564 277494 Negative_regulation NEDD9 CDH1 15144564 277495 Negative_regulation NEDD9 CDH1 15144564 277527 Negative_regulation NEDD9 DOCK3 25594051 2173936 Negative_regulation NEDD9 MLN 23441730 151336 Negative_regulation NEDD9 MYCN 22022577 2563932 Negative_regulation NEDD9 MYLIP 24426787 491119 Negative_regulation NEDD9 MYO10 22347397 2595818 Negative_regulation NEDD9 MYO16 22347397 2595817 Negative_regulation NEDD9 MYO19 22347397 2595816 Negative_regulation NEDD9 MYO6 22347397 2595819 Negative_regulation NEDD9 PLK1 23475109 605820 Negative_regulation NEDD9 RAC1 25594051 2173937 Negative_regulation NEDD9 RAC2 25594051 2173938 Negative_regulation NEDD9 RAC3 25594051 2173939 Negative_regulation NEDD9 SMAD3 15144564 277568 Negative_regulation NEDD9 SMAD3 15144564 277573 Negative_regulation NEDD9 SMURF2 20825672 585597 Negative_regulation NEDD9 SMURF2 20825672 585598 Negative_regulation NEDD9 SMURF2 20825672 585605 Negative_regulation NEDD9 SMURF2 20825672 585611 Negative_regulation NEDD9 SMURF2 20825672 585612 Negative_regulation NEDD9 WASF2 25594051 2173935 Negative_regulation NELFCD CD14 15975149 3105077 Negative_regulation NELFCD FAS 16618792 1540106 Negative_regulation NELFCD FAS 19487421 1555091 Negative_regulation NELFCD IL1RL1 21629437 672865 Negative_regulation NELFCD STAT4 10449525 1512279 Negative_regulation NELFCD STAT4 23990947 2840499 Negative_regulation NELFCD TLR7 16365150 1538989 Negative_regulation NELFCD TLR7 22927956 2681205 Negative_regulation NELFCD TNF 9151895 1601146 Negative_regulation NELFCD TNFSF10 23497038 1666077 Negative_regulation NELFCD TNFSF10 23497038 1666081 Negative_regulation NELFCD TNFSF10 23497038 1666082 Negative_regulation NELFCD TNFSF10 23497038 1666085 Negative_regulation NES APP 24232259 840047 Negative_regulation NES ARG1 21708948 1192326 Negative_regulation NES ARG2 21708948 1192327 Negative_regulation NES BMI1 22275880 929012 Negative_regulation NES CD40LG 18053121 384482 Negative_regulation NES CD46 25327364 3146168 Negative_regulation NES CDCA5 25329792 3016295 Negative_regulation NES CPEB1 25216517 2199694 Negative_regulation NES F2R 18053121 384484 Negative_regulation NES GFAP 22650359 1506414 Negative_regulation NES GFAP 22650359 1506417 Negative_regulation NES GRIN2A 23596395 866780 Negative_regulation NES IPO7 24490135 853676 Negative_regulation NES MYC 21304179 2174841 Negative_regulation NES MYLIP 23016664 387850 Negative_regulation NES MYLIP 23016664 387857 Negative_regulation NES MZF1 25436607 3030596 Negative_regulation NES PARP10 22176891 3214652 Negative_regulation NES PTPN11 22176891 3214653 Negative_regulation NES SETD2 25088159 412641 Negative_regulation NES TREH 25003205 2986946 Negative_regulation NES WT1 20066433 2242864 Negative_regulation NEUROD1 DAPK1 24853415 575989 Negative_regulation NEUROD1 EPHB2 21203386 2489614 Negative_regulation NEUROD1 EPHB2 24744103 494739 Negative_regulation NEUROD1 IFI27 21566658 547259 Negative_regulation NEUROD1 JAG1 22685423 2335916 Negative_regulation NEUROD1 MAP2K6 21203386 2489620 Negative_regulation NEUROD1 PGC 24843456 1493268 Negative_regulation NEUROD1 TMOD1 23638401 2236510 Negative_regulation NEUROD1 TNF 23236394 2726121 Negative_regulation NEUROD1 TNF 23236394 2726151 Negative_regulation NEUROD1 TNF 23236394 2726182 Negative_regulation NEUROD1 TNF 25109373 1483716 Negative_regulation NEUROD1 ZFP57 22735705 2079191 Negative_regulation NEUROD2 DAPK1 24853415 575990 Negative_regulation NEUROD2 EPHB2 21203386 2489622 Negative_regulation NEUROD2 EPHB2 24744103 494740 Negative_regulation NEUROD2 IFI27 21566658 547260 Negative_regulation NEUROD2 JAG1 22685423 2335918 Negative_regulation NEUROD2 MAP2K6 21203386 2489628 Negative_regulation NEUROD2 TMOD1 23638401 2236512 Negative_regulation NEUROD2 TNF 23236394 2726122 Negative_regulation NEUROD2 TNF 23236394 2726152 Negative_regulation NEUROD2 TNF 23236394 2726183 Negative_regulation NEUROD2 TNF 25109373 1483717 Negative_regulation NEUROD2 ZFP57 22735705 2079209 Negative_regulation NEUROD4 DAPK1 24853415 575987 Negative_regulation NEUROD4 EPHB2 21203386 2489598 Negative_regulation NEUROD4 EPHB2 24744103 494736 Negative_regulation NEUROD4 IFI27 21566658 547256 Negative_regulation NEUROD4 JAG1 22685423 2335912 Negative_regulation NEUROD4 MAP2K6 21203386 2489604 Negative_regulation NEUROD4 TMOD1 23638401 2236506 Negative_regulation NEUROD4 TNF 23236394 2726119 Negative_regulation NEUROD4 TNF 23236394 2726149 Negative_regulation NEUROD4 TNF 23236394 2726180 Negative_regulation NEUROD4 TNF 25109373 1483714 Negative_regulation NEUROD4 ZFP57 22735705 2079155 Negative_regulation NEUROD6 DAPK1 24853415 575988 Negative_regulation NEUROD6 EPHB2 21203386 2489606 Negative_regulation NEUROD6 EPHB2 24744103 494737 Negative_regulation NEUROD6 IFI27 21566658 547257 Negative_regulation NEUROD6 JAG1 22685423 2335914 Negative_regulation NEUROD6 MAP2K6 21203386 2489612 Negative_regulation NEUROD6 TMOD1 23638401 2236508 Negative_regulation NEUROD6 TNF 23236394 2726120 Negative_regulation NEUROD6 TNF 23236394 2726150 Negative_regulation NEUROD6 TNF 23236394 2726181 Negative_regulation NEUROD6 TNF 25109373 1483715 Negative_regulation NEUROD6 ZFP57 22735705 2079173 Negative_regulation NF2 CCND1 17924978 452637 Negative_regulation NF2 EPHB2 20890305 2136430 Negative_regulation NFASC ANK1 9151675 1459985 Negative_regulation NFASC ANK1 9660878 1468376 Negative_regulation NFASC ANK2 9151675 1459986 Negative_regulation NFASC ANK2 9660878 1468377 Negative_regulation NFASC ANK3 9151675 1459987 Negative_regulation NFASC ANK3 9660878 1468378 Negative_regulation NFAT5 EPHB2 25152734 965840 Negative_regulation NFATC1 CTGF 12810687 1527671 Negative_regulation NFATC1 RCAN1 19860902 526168 Negative_regulation NFATC1 TNF 23082080 816034 Negative_regulation NFATC2 CAPN8 23039869 1895585 Negative_regulation NFATC4 EPHB2 25514788 3034636 Negative_regulation NFE2L2 EDN2 23691261 2225837 Negative_regulation NFE2L2 EPHB2 21270272 717467 Negative_regulation NFIX SORL1 16930450 1890511 Negative_regulation NFKB1 ARSA 24039842 2844898 Negative_regulation NFKB1 ARSA 24039842 2844933 Negative_regulation NFKB1 GPR132 19602228 1897249 Negative_regulation NFKB1 LBP 1380063 1528800 Negative_regulation NFKB1 LBP 1380063 1528803 Negative_regulation NFKB1 SPHK1 20634980 2455693 Negative_regulation NFKB1 TLR7 23506673 1036634 Negative_regulation NFKB1 TLR7 PMC2756345 495796 Negative_regulation NFKB1 TM4SF19 25344917 2206150 Negative_regulation NFKB1 TNF 18834508 583303 Negative_regulation NFKB1 TNF 21539730 1626347 Negative_regulation NFKB1 TNF 21810263 1659158 Negative_regulation NFKB1 TNF 22375551 1230314 Negative_regulation NFKB1 TNF 22787387 742501 Negative_regulation NFKB1 TNF 23593011 2345222 Negative_regulation NFKB1 TNF 23634661 1666613 Negative_regulation NFKB1 TNF 23969857 564897 Negative_regulation NFKB1 TNF 23976842 742710 Negative_regulation NFKB1 TNF 24586568 2925504 Negative_regulation NFKB1 TNF 8655581 1451889 Negative_regulation NFKB1 TNF 9788890 798121 Negative_regulation NFKB1 ZFP57 24294107 679700 Negative_regulation NFKBIZ TNF 20374638 328786 Negative_regulation NGF EPHB2 21762482 387003 Negative_regulation NGF FAS 11980919 1282317 Negative_regulation NGF MAP2K6 21762482 387009 Negative_regulation NGF NGFR 1447305 1298722 Negative_regulation NGF NGFR 1671048 1329980 Negative_regulation NGF NGFR 8253850 1446430 Negative_regulation NGF TNF 23365678 2745512 Negative_regulation NGF TNF 24884664 1668097 Negative_regulation NGFR AKT1S1 23951412 170636 Negative_regulation NGFR FYN 22880054 2673779 Negative_regulation NGFR MLST8 23951412 170635 Negative_regulation NGFR MTOR 23951412 170638 Negative_regulation NGFR NGF 1447305 1298723 Negative_regulation NGFR NGF 1671048 1329981 Negative_regulation NGFR RPTOR 23951412 170637 Negative_regulation NGFR SOX10 22492709 2074590 Negative_regulation NGFR SYK 22880054 2673778 Negative_regulation NHP2L1 RNASE1 25060708 1018336 Negative_regulation NKRF ALOX5 24288682 185442 Negative_regulation NKX2-1 TNF 25303045 3014712 Negative_regulation NLN ZFP57 24846143 2972095 Negative_regulation NLRP3 IL1B 23915129 359283 Negative_regulation NM ITGB2 11457896 1519992 Negative_regulation NM ITGB2 11457896 1519993 Negative_regulation NM MUC16 21785567 1222342 Negative_regulation NM TNF 18475491 1744032 Negative_regulation NM TNF 18475491 1744033 Negative_regulation NM TNF 18475491 1744043 Negative_regulation NME1 EFNB1 23495724 1641645 Negative_regulation NME1 EPHB2 24829611 1650685 Negative_regulation NMNAT2 C9orf3 21144000 258300 Negative_regulation NMNAT2 FAS 25271157 1211026 Negative_regulation NMNAT2 TAP1 25271157 1211028 Negative_regulation NMNAT2 TAP2 25271157 1211027 Negative_regulation NMNAT2 TAP2 25271157 1211029 Negative_regulation NMU SYNM 4614857 443596 Negative_regulation NOD2 TCN1 21931826 2554963 Negative_regulation NOD2 TLR7 24658574 2937841 Negative_regulation NOD2 TNF 21779525 2115054 Negative_regulation NOP10 RNASE1 25060708 1018330 Negative_regulation NOP14 RNASE1 25060708 1018332 Negative_regulation NOP16 RNASE1 25060708 1018334 Negative_regulation NOP2 RNASE1 25060708 1018337 Negative_regulation NOP56 RNASE1 25060708 1018331 Negative_regulation NOP58 RNASE1 25060708 1018335 Negative_regulation NOP9 RNASE1 25060708 1018333 Negative_regulation NOS1 ANGPT1 22125558 1709957 Negative_regulation NOS1 CAPN8 24736629 2953386 Negative_regulation NOS1 EPHB2 19343212 3043666 Negative_regulation NOS1 EPHB2 19343212 3043667 Negative_regulation NOS1 EPHB2 19343212 3043688 Negative_regulation NOS1 EPHB2 19343212 3043689 Negative_regulation NOS1 EPHB2 19343212 3043690 Negative_regulation NOS1 EPHB2 19343212 3043698 Negative_regulation NOS1 S100B 25034944 1943559 Negative_regulation NOS1 TNF 12225613 658343 Negative_regulation NOS1 TNF 19098937 6827 Negative_regulation NOS1 TNF 22359588 2597946 Negative_regulation NOS1 TNF 23735240 1666749 Negative_regulation NOS1 TNF 24499158 2113950 Negative_regulation NOS1 TNF 24788542 2959137 Negative_regulation NOS2 EPHB2 25005778 297581 Negative_regulation NOS2 FBXO32 18461174 2388471 Negative_regulation NOS2 ID1 24749110 1022601 Negative_regulation NOS2 IL1B 22611495 154969 Negative_regulation NOS2 LBP 23517687 294303 Negative_regulation NOS2 S100B 25034944 1943560 Negative_regulation NOS2 TNF 12225613 658371 Negative_regulation NOS2 TNF 12417483 791239 Negative_regulation NOS2 TNF 15498105 390227 Negative_regulation NOS2 TNF 19098937 6828 Negative_regulation NOS2 TNF 22359588 2597948 Negative_regulation NOS2 TNF 22506619 451406 Negative_regulation NOS2 TNF 23035900 1231289 Negative_regulation NOS2 TNF 23531541 1103870 Negative_regulation NOS2 TNF 23717114 1614109 Negative_regulation NOS2 TNF 23717159 1614373 Negative_regulation NOS2 TNF 23970812 1754531 Negative_regulation NOS2 TNF 24499158 2113951 Negative_regulation NOS2 TNF 24788542 2959138 Negative_regulation NOS2 TNF 25141004 3000418 Negative_regulation NOS2 TNF 25314304 3015605 Negative_regulation NOS2 TNF 25352548 2105759 Negative_regulation NOS2 TNF 25435878 1074942 Negative_regulation NOS2 TNF 25587567 3157328 Negative_regulation NOS2 TNF 7530759 1589925 Negative_regulation NOS2 TNF 9883971 1764121 Negative_regulation NOS3 ANGPT1 18835934 707031 Negative_regulation NOS3 ANGPT1 22558265 2624917 Negative_regulation NOS3 CAPN8 23533715 1080939 Negative_regulation NOS3 EDN2 25599087 33756 Negative_regulation NOS3 EPHB2 25000310 216080 Negative_regulation NOS3 FOXO1 19584310 710414 Negative_regulation NOS3 FOXO1 19584310 710421 Negative_regulation NOS3 MAP2K6 19707375 175690 Negative_regulation NOS3 S100B 25034944 1943561 Negative_regulation NOS3 TNF 12225613 658399 Negative_regulation NOS3 TNF 19098937 6829 Negative_regulation NOS3 TNF 19118493 650999 Negative_regulation NOS3 TNF 19188427 707893 Negative_regulation NOS3 TNF 22359588 2597950 Negative_regulation NOS3 TNF 22802702 1714281 Negative_regulation NOS3 TNF 22802702 1714282 Negative_regulation NOS3 TNF 24304882 1709584 Negative_regulation NOS3 TNF 24499158 2113952 Negative_regulation NOS3 TNF 24719876 188784 Negative_regulation NOS3 TNF 24788542 2959139 Negative_regulation NOS3 TNF 25009787 3094655 Negative_regulation NOS3 TNF 25009787 3094664 Negative_regulation NOS3 TNF 9034139 1600013 Negative_regulation NOTCH1 AXIN2 21998560 2294790 Negative_regulation NOTCH1 EPHB2 15685243 425310 Negative_regulation NOTCH1 F2R 19165340 2404582 Negative_regulation NOTCH1 FHL1 24952875 274068 Negative_regulation NOTCH1 FOXO1 22117545 3169143 Negative_regulation NOTCH1 FOXO1 24979718 1942955 Negative_regulation NOTCH1 ID1 22393458 2608286 Negative_regulation NOTCH1 JAG1 20016694 1160869 Negative_regulation NOTCH1 JAG1 23967210 2834849 Negative_regulation NOTCH1 JAG1 24708907 6075 Negative_regulation NOTCH1 JAG1 25035811 1494844 Negative_regulation NOTCH1 JAG1 25309874 948786 Negative_regulation NOTCH1 KLF9 24349493 2898336 Negative_regulation NOTCH1 MAML3 17998388 1547710 Negative_regulation NOTCH1 MAML3 19508709 1850815 Negative_regulation NOTCH1 NR2F1 24349493 2898343 Negative_regulation NOTCH1 NRARP 21795391 1792894 Negative_regulation NOTCH1 NRARP 21795391 1792898 Negative_regulation NOTCH1 PLAU 22004682 1863732 Negative_regulation NOTCH1 TNF 20814569 2473427 Negative_regulation NOTCH1 TNF 20814569 2473428 Negative_regulation NOTCH1 TNF 20814569 2473441 Negative_regulation NOTCH1 TNF 20814569 2473442 Negative_regulation NOTCH1 TNF 20814569 2473444 Negative_regulation NOTCH1 TNF 20814569 2473448 Negative_regulation NOTCH1 TNF 20814569 2473449 Negative_regulation NOTCH1 TNF 20814569 2473450 Negative_regulation NOTCH1 TNF 20814569 2473466 Negative_regulation NOTCH1 TNF 20967264 2478602 Negative_regulation NOTCH1 TNF 23873298 1108844 Negative_regulation NOTCH1 TNF 24991087 1759992 Negative_regulation NOTCH2 AXIN2 21998560 2294802 Negative_regulation NOTCH2 EPHB2 15685243 425311 Negative_regulation NOTCH2 F2R 19165340 2404583 Negative_regulation NOTCH2 FHL1 24952875 274069 Negative_regulation NOTCH2 FOXO1 22117545 3169147 Negative_regulation NOTCH2 FOXO1 24979718 1942956 Negative_regulation NOTCH2 JAG1 20016694 1160870 Negative_regulation NOTCH2 JAG1 24708907 6076 Negative_regulation NOTCH2 JAG1 25035811 1494845 Negative_regulation NOTCH2 JAG1 25309874 948787 Negative_regulation NOTCH2 MAML3 17998388 1547713 Negative_regulation NOTCH2 MAML3 19508709 1850818 Negative_regulation NOTCH2 NR2F1 24349493 2898344 Negative_regulation NOTCH2 NRARP 21795391 1792895 Negative_regulation NOTCH2 NRARP 21795391 1792899 Negative_regulation NOTCH2 TNF 20814569 2473452 Negative_regulation NOTCH2 TNF 23531541 1103793 Negative_regulation NOTCH3 ANGPT1 22558265 2624887 Negative_regulation NOTCH3 ANGPT1 22558265 2624912 Negative_regulation NOTCH3 AXIN2 21998560 2294814 Negative_regulation NOTCH3 EPHB2 15685243 425312 Negative_regulation NOTCH3 F2R 19165340 2404584 Negative_regulation NOTCH3 FHL1 24952875 274070 Negative_regulation NOTCH3 FOXO1 22117545 3169151 Negative_regulation NOTCH3 FOXO1 24979718 1942957 Negative_regulation NOTCH3 JAG1 20016694 1160871 Negative_regulation NOTCH3 JAG1 22187650 1145458 Negative_regulation NOTCH3 JAG1 24708907 6077 Negative_regulation NOTCH3 JAG1 25035811 1494846 Negative_regulation NOTCH3 JAG1 25309874 948788 Negative_regulation NOTCH3 MAML3 17998388 1547716 Negative_regulation NOTCH3 MAML3 19508709 1850821 Negative_regulation NOTCH3 NR2F1 24349493 2898345 Negative_regulation NOTCH3 NRARP 21795391 1792896 Negative_regulation NOTCH3 NRARP 21795391 1792900 Negative_regulation NOTCH3 TNF 20814569 2473454 Negative_regulation NOTCH3 TNF 23531541 1103849 Negative_regulation NOTCH4 AXIN2 21998560 2294826 Negative_regulation NOTCH4 EPHB2 15685243 425313 Negative_regulation NOTCH4 F2R 19165340 2404585 Negative_regulation NOTCH4 FHL1 24952875 274071 Negative_regulation NOTCH4 FOXO1 22117545 3169155 Negative_regulation NOTCH4 FOXO1 24979718 1942958 Negative_regulation NOTCH4 JAG1 20016694 1160872 Negative_regulation NOTCH4 JAG1 24708907 6078 Negative_regulation NOTCH4 JAG1 25035811 1494847 Negative_regulation NOTCH4 JAG1 25309874 948789 Negative_regulation NOTCH4 MAML3 17998388 1547719 Negative_regulation NOTCH4 MAML3 19508709 1850824 Negative_regulation NOTCH4 NR2F1 24349493 2898346 Negative_regulation NOTCH4 NRARP 21795391 1792897 Negative_regulation NOTCH4 NRARP 21795391 1792901 Negative_regulation NOTCH4 TNF 20814569 2473456 Negative_regulation NOTCH4 TNF 23531541 1103795 Negative_regulation NOTCH4 TNF 23531541 1103925 Negative_regulation NOV FOXO1 23705021 2797492 Negative_regulation NOV TNF 24722330 2951158 Negative_regulation NOX1 ARSA 22829962 2224608 Negative_regulation NOX1 TNF 21645369 2111699 Negative_regulation NOX1 TNF 24396568 2227985 Negative_regulation NOX1 TNF 24396568 2227989 Negative_regulation NOX3 ARSA 22829962 2224609 Negative_regulation NOX3 TNF 21645369 2111700 Negative_regulation NOX3 TNF 24396568 2227986 Negative_regulation NOX3 TNF 24396568 2227990 Negative_regulation NOX4 ARSA 22829962 2224610 Negative_regulation NOX4 EPHB2 22140508 2574862 Negative_regulation NOX4 TNF 21645369 2111701 Negative_regulation NOX4 TNF 24396568 2227987 Negative_regulation NOX4 TNF 24396568 2227991 Negative_regulation NOX5 ARSA 22829962 2224607 Negative_regulation NOX5 TNF 21645369 2111698 Negative_regulation NOX5 TNF 24396568 2227984 Negative_regulation NOX5 TNF 24396568 2227988 Negative_regulation NPAT JAG1 16410827 2302156 Negative_regulation NPPA TNF 24369440 1755938 Negative_regulation NPPA TNF 24369440 1755939 Negative_regulation NPPA TNF 24369440 1755940 Negative_regulation NPR1 TNF 24369440 1755945 Negative_regulation NPS TNF 24642694 2935183 Negative_regulation NPY TUB 18183286 2382368 Negative_regulation NPY4R MAP2K6 21811441 933329 Negative_regulation NPY4R PCDH19 23600975 89799 Negative_regulation NPY4R PCDH8 23600975 89804 Negative_regulation NPY4R PPP1R1A 19200380 324790 Negative_regulation NPY4R TFPI2 24958351 1875083 Negative_regulation NR2F1 EED 23666625 2088353 Negative_regulation NR2F1 EZH2 23666625 2088354 Negative_regulation NR2F1 FGF1 18625063 2000466 Negative_regulation NR2F1 FGF10 18625063 2000467 Negative_regulation NR2F1 FGF11 18625063 2000468 Negative_regulation NR2F1 FGF12 18625063 2000469 Negative_regulation NR2F1 FGF13 18625063 2000470 Negative_regulation NR2F1 FGF14 18625063 2000471 Negative_regulation NR2F1 FGF16 18625063 2000472 Negative_regulation NR2F1 FGF17 18625063 2000473 Negative_regulation NR2F1 FGF18 18625063 2000474 Negative_regulation NR2F1 FGF19 18625063 2000475 Negative_regulation NR2F1 FGF2 18625063 2000476 Negative_regulation NR2F1 FGF20 18625063 2000477 Negative_regulation NR2F1 FGF21 18625063 2000478 Negative_regulation NR2F1 FGF22 18625063 2000479 Negative_regulation NR2F1 FGF23 18625063 2000480 Negative_regulation NR2F1 FGF3 18625063 2000481 Negative_regulation NR2F1 FGF4 18625063 2000482 Negative_regulation NR2F1 FGF5 18625063 2000483 Negative_regulation NR2F1 FGF6 18625063 2000484 Negative_regulation NR2F1 FGF7 18625063 2000485 Negative_regulation NR2F1 FGF8 18625063 2000233 Negative_regulation NR2F1 FGF8 18625063 2000486 Negative_regulation NR2F1 FGF9 18625063 2000487 Negative_regulation NR2F1 HDAC1 23666625 2088355 Negative_regulation NR2F1 HDAC2 23666625 2088356 Negative_regulation NR2F1 PGR 24212637 497867 Negative_regulation NR2F1 RBBP4 23666625 2088357 Negative_regulation NR2F1 RBBP7 23666625 2088358 Negative_regulation NR2F1 SUZ12 23666625 2088330 Negative_regulation NR2F1 SUZ12 23666625 2088352 Negative_regulation NR2F1 YY1 23666625 2088351 Negative_regulation NR3C1 TNF 23034049 3113193 Negative_regulation NR3C2 CD22 1847724 1551018 Negative_regulation NR3C2 ITGAL 2147949 1563308 Negative_regulation NR3C2 ITGAL 2562848 1577402 Negative_regulation NR4A1 FOXO1 24638142 2935092 Negative_regulation NR4A2 EPHB2 19522012 3170490 Negative_regulation NR4A2 EPHB2 19522012 3170531 Negative_regulation NR4A2 MSX1 18826576 1832827 Negative_regulation NR4A2 RASD1 21915321 2553222 Negative_regulation NR4A2 RASD1 21915321 2553271 Negative_regulation NR5A1 FOXO1 23675313 938083 Negative_regulation NRAS CCND1 18834508 583304 Negative_regulation NRAS EPHB2 19492026 3399 Negative_regulation NRAS EPHB2 19953086 1903259 Negative_regulation NRAS EPHB2 22701199 2234550 Negative_regulation NRAS EPHB2 25003010 3092915 Negative_regulation NRAS EPHB2 25275294 2202448 Negative_regulation NRAS IFI27 14680481 458015 Negative_regulation NRAS LGALS7B 23530091 2182802 Negative_regulation NRAS LGALS7B 23530091 2182803 Negative_regulation NRAS LGALS7B 23530091 2182804 Negative_regulation NRAS LGALS7B 23530091 2182805 Negative_regulation NRAS LGALS7B 23530091 2182831 Negative_regulation NRAS LGALS7B 23530091 2182869 Negative_regulation NRAS LGALS7B 23530091 2182870 Negative_regulation NRAS LGALS7B 23530091 2182899 Negative_regulation NRAS LGALS7B 23530091 2182905 Negative_regulation NRAS LGALS7B 23530091 2182917 Negative_regulation NRAS MAP2K6 21151481 2485061 Negative_regulation NRAS MAP2K6 24392017 2905221 Negative_regulation NRAS MAP2K6 24970815 2194262 Negative_regulation NRCAM NFASC 8922386 1457768 Negative_regulation NRF1 CCND1 20721988 774933 Negative_regulation NRF1 CCND1 24910535 1062975 Negative_regulation NRF1 PGC 24843413 1493129 Negative_regulation NRG1 EPHB2 24391468 2285151 Negative_regulation NRG1 TNF 23936190 2829635 Negative_regulation NRG2 EPHB2 24391468 2285152 Negative_regulation NRG3 EPHB2 24391468 2285153 Negative_regulation NRG4 EPHB2 24391468 2285147 Negative_regulation NRN1 EPHB2 23066017 1205238 Negative_regulation NRXN3 FOXQ1 23383267 2749799 Negative_regulation NRXN3 FOXQ1 23383267 2749813 Negative_regulation NRXN3 FOXQ1 23383267 2749815 Negative_regulation NT5E BRAP 1911182 431522 Negative_regulation NT5E GFI1 24131921 545093 Negative_regulation NT5E HIF1A 18404508 3089526 Negative_regulation NT5E IFNAR1 23149581 84943 Negative_regulation NT5E NT5M 24205323 2875948 Negative_regulation NT5E SETD2 18404475 3087788 Negative_regulation NT5E THY1 21151872 2485249 Negative_regulation NT5E TNF 23125525 1225594 Negative_regulation NT5M NT5E 24205323 2875947 Negative_regulation NTN1 UNC5B 19071062 691829 Negative_regulation NTRK2 NT5E 24758840 619698 Negative_regulation NTRK2 SORL1 23977241 2839404 Negative_regulation NTRK2 TGM2 23503168 2117285 Negative_regulation NTRK3 NT5E 24758840 619701 Negative_regulation NUP153 INPP4B 25126743 2998003 Negative_regulation NUP210 INPP4B 25126743 2998002 Negative_regulation NUP214 INPP4B 25126743 2998004 Negative_regulation NUP43 EPHB2 20090934 2437590 Negative_regulation NUP43 MIP 17233909 351841 Negative_regulation NUP43 RGS2 18067675 461927 Negative_regulation NUP43 TNF 24215724 538185 Negative_regulation NUP62 INPP4B 25126743 2998005 Negative_regulation OAS1 MX2 23384108 3101788 Negative_regulation OCLN EPHB2 20442784 2449120 Negative_regulation OCLN MMP7 20442866 3046769 Negative_regulation OCLN TNF 20693346 716066 Negative_regulation OCLN TNF 23924897 1817640 Negative_regulation OCLN TNF 23924897 1817701 Negative_regulation OCLN TNF 24992685 2986593 Negative_regulation OGG1 CAPN8 23868064 564104 Negative_regulation OLFM4 NDUFA13 21566745 3188845 Negative_regulation OLFM4 SMARCA4 25010414 2360338 Negative_regulation OLR1 FAS 21078775 1637442 Negative_regulation OPA1 EPHB2 21789185 2538064 Negative_regulation OPA1 TNF 23670971 727349 Negative_regulation OPN3 NR2F1 24058409 2847291 Negative_regulation OPN4 NR2F1 24058409 2847293 Negative_regulation OPN5 NR2F1 24058409 2847295 Negative_regulation ORM1 LBP 24743550 3066755 Negative_regulation ORM2 LBP 24743550 3066756 Negative_regulation OSM ADAMTS1 20645923 147881 Negative_regulation OSM STK39 PMC2750795 450350 Negative_regulation OSR1 COMT 19228412 143277 Negative_regulation OSR1 FOS 25226030 3007626 Negative_regulation OSR1 GEMIN4 21343295 1190836 Negative_regulation OSR1 MIR17HG 24068957 2350645 Negative_regulation OXA1L FAS 24691448 2947764 Negative_regulation OXA1L WNT7A 23862015 170023 Negative_regulation OXT NR2F1 22363799 2601970 Negative_regulation OXTR ESR1 21811473 972198 Negative_regulation OXTR ESR1 22375116 897459 Negative_regulation OXTR HDAC1 24030655 1076937 Negative_regulation OXTR HDAC10 24030655 1076935 Negative_regulation OXTR HDAC11 24030655 1076936 Negative_regulation OXTR HDAC2 24030655 1076938 Negative_regulation OXTR HDAC3 24030655 1076939 Negative_regulation OXTR HDAC4 24030655 1076930 Negative_regulation OXTR HDAC5 24030655 1076934 Negative_regulation OXTR HDAC6 24030655 1076931 Negative_regulation OXTR HDAC7 24030655 1076933 Negative_regulation OXTR HDAC8 24030655 1076929 Negative_regulation OXTR HDAC9 24030655 1076932 Negative_regulation OXTR MYL1 23948067 3102097 Negative_regulation OXTR MYL10 23948067 3102095 Negative_regulation OXTR MYL2 23948067 3102098 Negative_regulation OXTR MYL3 23948067 3102099 Negative_regulation OXTR MYL4 23948067 3102100 Negative_regulation OXTR MYL5 23948067 3102101 Negative_regulation OXTR MYL6 23948067 3102102 Negative_regulation OXTR MYL7 23948067 3102094 Negative_regulation OXTR MYL9 23948067 3102093 Negative_regulation OXTR MYLIP 22685266 787758 Negative_regulation OXTR PGR 15236653 3095806 Negative_regulation OXTR PPP1R12A 23948067 3102103 Negative_regulation OXTR RGS2 18067675 461883 Negative_regulation OXTR RGS2 18067675 461884 Negative_regulation OXTR RGS2 18067675 461885 Negative_regulation OXTR RGS2 18067675 461886 Negative_regulation OXTR RND3 23948067 3102096 Negative_regulation OXTR ZEB1 22028729 633356 Negative_regulation OXTR ZEB1 22028729 633462 Negative_regulation OXTR ZEB2 22028729 633357 Negative_regulation OXTR ZEB2 22028729 633463 Negative_regulation P2RX4 TNF 22547202 3090955 Negative_regulation P2RY12 ARSA 24281379 2245149 Negative_regulation P4HB TNF 8691130 1598116 Negative_regulation PAF1 F2R PMC2756345 495994 Negative_regulation PAF1 LPCAT1 25415055 177538 Negative_regulation PAF1 TNF 18472926 1743190 Negative_regulation PAF1 TNF 3119758 1580175 Negative_regulation PAFAH1B1 CAPN8 19734909 1960721 Negative_regulation PAFAH1B1 CAPN8 19734909 1960777 Negative_regulation PAFAH1B1 CAPN8 19734909 1960791 Negative_regulation PAGR1 MAP2K6 22970192 2687695 Negative_regulation PAH STK39 21533110 2514433 Negative_regulation PAK1 EPHB2 20195469 2441835 Negative_regulation PAK2 EPHB2 20195469 2441839 Negative_regulation PAK3 EPHB2 20195469 2441843 Negative_regulation PAK4 EPHB2 20195469 2441817 Negative_regulation PAK6 EPHB2 20195469 2441821 Negative_regulation PAK7 EPHB2 20195469 2441813 Negative_regulation PAM TNF 19966777 1960917 Negative_regulation PARK10 PGC 22916173 2680137 Negative_regulation PARK11 PGC 22916173 2680138 Negative_regulation PARK12 PGC 22916173 2680139 Negative_regulation PARK16 PGC 22916173 2680140 Negative_regulation PARK2 PGC 22916173 2680141 Negative_regulation PARK3 PGC 22916173 2680142 Negative_regulation PARK7 PGC 22916173 2680136 Negative_regulation PARK7 RAB31 23892275 18115 Negative_regulation PARK7 RAB31 23892275 18277 Negative_regulation PARN TNF 21569625 1723646 Negative_regulation PARN TNF 24086143 2350899 Negative_regulation PARP1 CAPN8 23056924 140343 Negative_regulation PARP1 FAS 9730899 1603635 Negative_regulation PARP1 ID1 20804590 1228615 Negative_regulation PARP1 MMP28 23110201 2707064 Negative_regulation PARP1 MMP7 23110201 2707079 Negative_regulation PARP1 OSR1 24931004 1681273 Negative_regulation PARP1 TNFSF10 23533807 1154024 Negative_regulation PARP1 TNFSF10 24434509 570869 Negative_regulation PARP10 FAS 9730899 1603630 Negative_regulation PARP10 ID1 20804590 1228610 Negative_regulation PARP10 OSR1 24931004 1681268 Negative_regulation PARP10 TNFSF10 23533807 1154019 Negative_regulation PARP10 TNFSF10 24434509 570864 Negative_regulation PARP11 FAS 9730899 1603603 Negative_regulation PARP11 ID1 20804590 1228607 Negative_regulation PARP11 OSR1 24931004 1681258 Negative_regulation PARP11 TNFSF10 23533807 1154016 Negative_regulation PARP11 TNFSF10 24434509 570861 Negative_regulation PARP12 FAS 9730899 1603628 Negative_regulation PARP12 ID1 20804590 1228608 Negative_regulation PARP12 OSR1 24931004 1681266 Negative_regulation PARP12 TNFSF10 23533807 1154017 Negative_regulation PARP12 TNFSF10 24434509 570862 Negative_regulation PARP14 FAS 9730899 1603641 Negative_regulation PARP14 ID1 20804590 1228619 Negative_regulation PARP14 OSR1 24931004 1681277 Negative_regulation PARP14 TNFSF10 23533807 1154028 Negative_regulation PARP14 TNFSF10 24434509 570873 Negative_regulation PARP15 FAS 9730899 1603633 Negative_regulation PARP15 ID1 20804590 1228613 Negative_regulation PARP15 OSR1 24931004 1681271 Negative_regulation PARP15 TNFSF10 23533807 1154022 Negative_regulation PARP15 TNFSF10 24434509 570867 Negative_regulation PARP16 FAS 9730899 1603631 Negative_regulation PARP16 ID1 20804590 1228611 Negative_regulation PARP16 OSR1 24931004 1681269 Negative_regulation PARP16 TNFSF10 23533807 1154020 Negative_regulation PARP16 TNFSF10 24434509 570865 Negative_regulation PARP2 FAS 9730899 1603637 Negative_regulation PARP2 ID1 20804590 1228617 Negative_regulation PARP2 OSR1 24931004 1681275 Negative_regulation PARP2 TNFSF10 23533807 1154026 Negative_regulation PARP2 TNFSF10 24434509 570871 Negative_regulation PARP3 FAS 9730899 1603640 Negative_regulation PARP3 ID1 20804590 1228618 Negative_regulation PARP3 OSR1 24931004 1681276 Negative_regulation PARP3 TNFSF10 23533807 1154027 Negative_regulation PARP3 TNFSF10 24434509 570872 Negative_regulation PARP4 FAS 9730899 1603636 Negative_regulation PARP4 ID1 20804590 1228616 Negative_regulation PARP4 OSR1 24931004 1681274 Negative_regulation PARP4 TNFSF10 23533807 1154025 Negative_regulation PARP4 TNFSF10 24434509 570870 Negative_regulation PARP6 FAS 9730899 1603634 Negative_regulation PARP6 ID1 20804590 1228614 Negative_regulation PARP6 OSR1 24931004 1681272 Negative_regulation PARP6 TNFSF10 23533807 1154023 Negative_regulation PARP6 TNFSF10 24434509 570868 Negative_regulation PARP8 FAS 9730899 1603632 Negative_regulation PARP8 ID1 20804590 1228612 Negative_regulation PARP8 OSR1 24931004 1681270 Negative_regulation PARP8 TNFSF10 23533807 1154021 Negative_regulation PARP8 TNFSF10 24434509 570866 Negative_regulation PARP9 FAS 9730899 1603629 Negative_regulation PARP9 ID1 20804590 1228609 Negative_regulation PARP9 OSR1 24931004 1681267 Negative_regulation PARP9 TNFSF10 23533807 1154018 Negative_regulation PARP9 TNFSF10 24434509 570863 Negative_regulation PAWR EPHB2 23760770 1141777 Negative_regulation PAX3 CCND1 23469153 2762475 Negative_regulation PAX3 CCND1 23469153 2762507 Negative_regulation PAX3 FOXO1 23469153 2762478 Negative_regulation PAX6 EPHB2 23874217 2347547 Negative_regulation PAX7 FOXO1 21143873 331781 Negative_regulation PAX7 TNF 25038756 496449 Negative_regulation PCBD1 FAS 10579724 1253151 Negative_regulation PCBD1 FAS 22979947 406958 Negative_regulation PCDH19 CTCF 22210889 2071189 Negative_regulation PCDH19 REST 20385576 2052929 Negative_regulation PCDH8 CTCF 22210889 2071194 Negative_regulation PCDH8 REST 20385576 2052934 Negative_regulation PCNA CCND1 16984628 370071 Negative_regulation PCNA CCND1 18648506 2393422 Negative_regulation PCNA CCND1 20631901 696672 Negative_regulation PCNA CCND1 21092078 258051 Negative_regulation PCNA CCND1 22276175 2590343 Negative_regulation PCNA CDKN1C 16207381 298605 Negative_regulation PCNA CDKN1C 17786216 2378015 Negative_regulation PCNA CDKN1C 21776388 1686284 Negative_regulation PCNA CDKN1C 22211105 1058720 Negative_regulation PCNA CDKN1C 22918239 541791 Negative_regulation PCNA CDKN1C 23000964 1928616 Negative_regulation PCNA CDKN1C 24224175 184948 Negative_regulation PCNA CDKN1C 24278753 3150651 Negative_regulation PCNA CTGF 23755163 2801572 Negative_regulation PCNA FAS 23017148 266312 Negative_regulation PCNA FOXO1 11277966 993991 Negative_regulation PCNA IFI27 10188908 414135 Negative_regulation PCNA IFI27 10389977 414448 Negative_regulation PCNA IFI27 11336477 418728 Negative_regulation PCNA IFI27 15201495 1634325 Negative_regulation PCNA IFI27 15603588 277984 Negative_regulation PCNA IFI27 16859513 460066 Negative_regulation PCNA IFI27 17092340 580174 Negative_regulation PCNA IFI27 17764562 461011 Negative_regulation PCNA IFI27 18069898 2304628 Negative_regulation PCNA IFI27 19602254 253748 Negative_regulation PCNA IFI27 19604372 1227237 Negative_regulation PCNA IFI27 19706164 1851292 Negative_regulation PCNA IFI27 21103079 2114976 Negative_regulation PCNA IFI27 21423803 2508392 Negative_regulation PCNA IFI27 22606274 2642681 Negative_regulation PCNA IFI27 22932419 406795 Negative_regulation PCNA IFI27 23409140 2753770 Negative_regulation PCNA IFI27 24419005 502722 Negative_regulation PCNA IFI27 24465590 2911189 Negative_regulation PCNA IFI27 24811221 2190598 Negative_regulation PCNA IFI27 25009787 3094640 Negative_regulation PCNA IFI27 25036575 496437 Negative_regulation PCNA IFI27 25141103 1129059 Negative_regulation PCNA IFI27 7559780 1437319 Negative_regulation PCNA IFI27 7577470 444052 Negative_regulation PCNA IFI27 7642695 1438094 Negative_regulation PCNA IFI27 7642695 1438095 Negative_regulation PCNA IFI27 8609171 1451031 Negative_regulation PCNA IFI27 8760794 1598727 Negative_regulation PCNA IFI27 8896600 1457021 Negative_regulation PCNA IFI27 8909543 1457387 Negative_regulation PCNA IFI27 8909543 1457388 Negative_regulation PCNA IFI27 9155043 446219 Negative_regulation PCNA IFI27 9166931 446226 Negative_regulation PCNA IFI27 9218727 446392 Negative_regulation PCNA IFI27 9365157 446663 Negative_regulation PCNA IFI27 9472642 446902 Negative_regulation PCSK1 MMP28 23936445 2830815 Negative_regulation PCSK1 MMP7 23936445 2830830 Negative_regulation PCSK2 MMP28 23936445 2830838 Negative_regulation PCSK2 MMP7 23936445 2830853 Negative_regulation PCSK4 MMP28 23936445 2830861 Negative_regulation PCSK4 MMP7 23936445 2830876 Negative_regulation PCSK5 MMP28 23936445 2830884 Negative_regulation PCSK5 MMP7 23936445 2830899 Negative_regulation PCSK6 MMP28 23936445 2830792 Negative_regulation PCSK6 MMP7 23936445 2830807 Negative_regulation PCSK7 MMP28 23936445 2830907 Negative_regulation PCSK7 MMP7 23936445 2830922 Negative_regulation PCSK9 AKT1S1 25110901 691687 Negative_regulation PCSK9 ANXA2 22848640 2669899 Negative_regulation PCSK9 ANXA2 22848640 2669900 Negative_regulation PCSK9 ANXA2 22848640 2669901 Negative_regulation PCSK9 ANXA2 22848640 2669910 Negative_regulation PCSK9 APOB 23400816 1206468 Negative_regulation PCSK9 EEF1A2 25426564 658120 Negative_regulation PCSK9 FURIN 23936445 2830622 Negative_regulation PCSK9 FXR1 21991404 1638794 Negative_regulation PCSK9 FXR1 25600226 143159 Negative_regulation PCSK9 FXR2 21991404 1638795 Negative_regulation PCSK9 FXR2 25600226 143160 Negative_regulation PCSK9 GCG 23298392 2113728 Negative_regulation PCSK9 HNF1A 19687008 1166604 Negative_regulation PCSK9 HNF1A 19687008 1166622 Negative_regulation PCSK9 HNF1A 25110901 691667 Negative_regulation PCSK9 LDLR 22848640 2669911 Negative_regulation PCSK9 LDLR 23226021 3209219 Negative_regulation PCSK9 LDLR 24115837 742802 Negative_regulation PCSK9 LDLR 24115837 742813 Negative_regulation PCSK9 MLST8 25110901 691675 Negative_regulation PCSK9 MLST8 25110901 691686 Negative_regulation PCSK9 MMP1 23936445 2830605 Negative_regulation PCSK9 MMP10 23936445 2830606 Negative_regulation PCSK9 MMP11 23936445 2830607 Negative_regulation PCSK9 MMP12 23936445 2830608 Negative_regulation PCSK9 MMP13 23936445 2830609 Negative_regulation PCSK9 MMP14 23936445 2830610 Negative_regulation PCSK9 MMP15 23936445 2830611 Negative_regulation PCSK9 MMP16 23936445 2830612 Negative_regulation PCSK9 MMP17 23936445 2830613 Negative_regulation PCSK9 MMP19 23936445 2830614 Negative_regulation PCSK9 MMP2 23936445 2830615 Negative_regulation PCSK9 MMP20 23936445 2830616 Negative_regulation PCSK9 MMP21 23936445 2830603 Negative_regulation PCSK9 MMP24 23936445 2830617 Negative_regulation PCSK9 MMP25 23936445 2830600 Negative_regulation PCSK9 MMP26 23936445 2830601 Negative_regulation PCSK9 MMP27 23936445 2830602 Negative_regulation PCSK9 MMP28 23936445 2830604 Negative_regulation PCSK9 MMP3 23936445 2830618 Negative_regulation PCSK9 MMP7 23936445 2830619 Negative_regulation PCSK9 MMP8 23936445 2830620 Negative_regulation PCSK9 MMP9 23936445 2830621 Negative_regulation PCSK9 MTOR 25110901 691677 Negative_regulation PCSK9 MTOR 25110901 691689 Negative_regulation PCSK9 RPTOR 25110901 691676 Negative_regulation PCSK9 RPTOR 25110901 691688 Negative_regulation PCSK9 SEC24A 23580231 748952 Negative_regulation PCSK9 SEC24A 23580231 748958 Negative_regulation PCSK9 SREBF2 18547436 1722726 Negative_regulation PCSK9 SREBF2 22355267 1059727 Negative_regulation PDC TLR7 21912648 2552530 Negative_regulation PDCD1 CLU 24672247 2122893 Negative_regulation PDCD1 MMP28 11250717 456471 Negative_regulation PDCD1 MMP7 11250717 456486 Negative_regulation PDCD1 TNF 12932288 99899 Negative_regulation PDCD1 TNF 1552286 1533904 Negative_regulation PDCD1 TNF 23285227 2733024 Negative_regulation PDCD1 TNF 7504062 1588772 Negative_regulation PDCD1 TNFSF10 18662397 1242886 Negative_regulation PDCD10 CLU 24672247 2122894 Negative_regulation PDCD10 MMP28 11250717 456493 Negative_regulation PDCD10 MMP7 11250717 456508 Negative_regulation PDCD10 TNF 12932288 99900 Negative_regulation PDCD10 TNF 1552286 1533905 Negative_regulation PDCD10 TNF 23285227 2733025 Negative_regulation PDCD10 TNF 7504062 1588773 Negative_regulation PDCD10 TNFSF10 18662397 1242888 Negative_regulation PDCD11 CLU 24672247 2122892 Negative_regulation PDCD11 MMP28 11250717 456449 Negative_regulation PDCD11 MMP7 11250717 456464 Negative_regulation PDCD11 TNF 12932288 99898 Negative_regulation PDCD11 TNF 1552286 1533903 Negative_regulation PDCD11 TNF 23285227 2733023 Negative_regulation PDCD11 TNF 7504062 1588771 Negative_regulation PDCD11 TNFSF10 18662397 1242884 Negative_regulation PDCD2 CLU 24672247 2122895 Negative_regulation PDCD2 MMP28 11250717 456515 Negative_regulation PDCD2 MMP7 11250717 456530 Negative_regulation PDCD2 TNF 12932288 99901 Negative_regulation PDCD2 TNF 1552286 1533906 Negative_regulation PDCD2 TNF 23285227 2733026 Negative_regulation PDCD2 TNF 7504062 1588774 Negative_regulation PDCD2 TNFSF10 18662397 1242890 Negative_regulation PDCD4 CLU 24672247 2122896 Negative_regulation PDCD4 MMP28 11250717 456537 Negative_regulation PDCD4 MMP7 11250717 456552 Negative_regulation PDCD4 TNF 12932288 99902 Negative_regulation PDCD4 TNF 1552286 1533907 Negative_regulation PDCD4 TNF 23285227 2733027 Negative_regulation PDCD4 TNF 7504062 1588775 Negative_regulation PDCD4 TNFSF10 18662397 1242892 Negative_regulation PDCD5 CLU 24672247 2122897 Negative_regulation PDCD5 MMP28 11250717 456559 Negative_regulation PDCD5 MMP7 11250717 456574 Negative_regulation PDCD5 TNF 12932288 99903 Negative_regulation PDCD5 TNF 1552286 1533908 Negative_regulation PDCD5 TNF 23285227 2733028 Negative_regulation PDCD5 TNF 7504062 1588776 Negative_regulation PDCD5 TNFSF10 18662397 1242894 Negative_regulation PDCD6 CLU 24672247 2122898 Negative_regulation PDCD6 MMP28 11250717 456581 Negative_regulation PDCD6 MMP7 11250717 456596 Negative_regulation PDCD6 TNF 12932288 99904 Negative_regulation PDCD6 TNF 1552286 1533909 Negative_regulation PDCD6 TNF 23285227 2733029 Negative_regulation PDCD6 TNF 7504062 1588777 Negative_regulation PDCD6 TNFSF10 18662397 1242896 Negative_regulation PDCD7 CLU 24672247 2122899 Negative_regulation PDCD7 MMP28 11250717 456603 Negative_regulation PDCD7 MMP7 11250717 456618 Negative_regulation PDCD7 TNF 12932288 99905 Negative_regulation PDCD7 TNF 1552286 1533910 Negative_regulation PDCD7 TNF 23285227 2733030 Negative_regulation PDCD7 TNF 7504062 1588778 Negative_regulation PDCD7 TNFSF10 18662397 1242898 Negative_regulation PDE3B TNF 23781214 878822 Negative_regulation PDE4B PDE4D 18044094 1071342 Negative_regulation PDE4D PDE4B 18044094 1071343 Negative_regulation PDE5A DMD 24391598 963243 Negative_regulation PDE6A CAPN8 24884644 389202 Negative_regulation PDE6B CAPN8 24884644 389216 Negative_regulation PDE6G CAPN8 24884644 389230 Negative_regulation PDE8B PDE10A 21152070 2486067 Negative_regulation PDHX TNF 24739042 3114536 Negative_regulation PDK1 TCN1 20489726 546965 Negative_regulation PDK4 FOXO1 23130316 730533 Negative_regulation PDK4 PGC 19435887 1165971 Negative_regulation PDLIM3 ACHE 22205996 2584046 Negative_regulation PDLIM7 ID1 21701587 2531207 Negative_regulation PDX1 FOXO1 20642839 1647378 Negative_regulation PDX1 FOXO1 21533167 2515313 Negative_regulation PDX1 FOXO1 21533167 2515314 Negative_regulation PDX1 FOXO1 22013015 720930 Negative_regulation PDX1 FOXO1 22384192 2607235 Negative_regulation PDX1 FOXO1 22384192 2607239 Negative_regulation PDX1 FOXO1 22384192 2607242 Negative_regulation PDX1 FOXO1 22384192 2607244 Negative_regulation PDX1 FOXO1 22384192 2607246 Negative_regulation PDX1 FOXO1 23424659 2755175 Negative_regulation PDX1 FOXO1 23533474 817784 Negative_regulation PDX1 FOXO1 24250814 2881699 Negative_regulation PDX1 FOXO1 24250814 2881706 Negative_regulation PDX1 PGC 23274887 725448 Negative_regulation PDX1 PGC 23274887 725470 Negative_regulation PDX1 PGC 23274887 725471 Negative_regulation PDZK1 SCARB1 19654867 2422722 Negative_regulation PEA15 EPHB2 23552738 2156581 Negative_regulation PECAM1 ACKR3 PMC3330033 1049438 Negative_regulation PECAM1 CXCL1 25261195 660760 Negative_regulation PECAM1 ENG 8655583 1451940 Negative_regulation PECAM1 GDNF 23758884 1868694 Negative_regulation PECAM1 GIF 23029004 2694109 Negative_regulation PECAM1 HGF 23622716 1617866 Negative_regulation PECAM1 KDR 22615904 2644168 Negative_regulation PECAM1 MICE 23251235 842897 Negative_regulation PECAM1 MYLIP 22792280 2661758 Negative_regulation PECAM1 NPY6R 18710921 1354890 Negative_regulation PECAM1 NPY6R 18710921 1354891 Negative_regulation PECAM1 PLAUR 21394106 487543 Negative_regulation PECAM1 PRKAA1 21876756 2547217 Negative_regulation PECAM1 PRKAA2 21876756 2547218 Negative_regulation PECAM1 PRKAB1 21876756 2547219 Negative_regulation PECAM1 PRKAB2 21876756 2547220 Negative_regulation PECAM1 PRKAG1 21876756 2547221 Negative_regulation PECAM1 PRKAG2 21876756 2547222 Negative_regulation PECAM1 PTPN11 23233201 1141328 Negative_regulation PECAM1 RASA1 10725328 1256538 Negative_regulation PECAM1 TNF 23029004 2694108 Negative_regulation PECAM1 VCAM1 22615904 2644167 Negative_regulation PECAM1 VIM 25261195 660759 Negative_regulation PER2 TNF 18854046 1727799 Negative_regulation PER2 TNF 24901009 1621713 Negative_regulation PER3 TNF 18854046 1727801 Negative_regulation PFN1 SMN2 22701806 2002701 Negative_regulation PFN2 SMN2 22701806 2002708 Negative_regulation PFN3 SMN2 22701806 2002687 Negative_regulation PFN4 SMN2 22701806 2002694 Negative_regulation PGC ACOT1 23226270 2724013 Negative_regulation PGC ADIPOR1 24843438 1493258 Negative_regulation PGC AKT1 24086476 2854335 Negative_regulation PGC AKT2 21297943 2498630 Negative_regulation PGC AKT2 24086476 2854336 Negative_regulation PGC AKT3 24086476 2854337 Negative_regulation PGC ANGPT2 23431467 1151255 Negative_regulation PGC ANGPTL3 25495645 216841 Negative_regulation PGC ATF6 23716639 2088909 Negative_regulation PGC CAMK1 20847946 3075363 Negative_regulation PGC CAMK1 20847946 3075420 Negative_regulation PGC CAMK4 20847946 3075364 Negative_regulation PGC CAMK4 20847946 3075421 Negative_regulation PGC CAPS 23968387 2233541 Negative_regulation PGC CAV1 24475013 2914591 Negative_regulation PGC CCNT1 22096235 2069575 Negative_regulation PGC CCNT2 22096235 2069576 Negative_regulation PGC CD36 23964012 781873 Negative_regulation PGC CORO2A 24492630 1940601 Negative_regulation PGC CREB1 22288011 2009380 Negative_regulation PGC CREB3 22288011 2009381 Negative_regulation PGC CREB5 22288011 2009379 Negative_regulation PGC CRIM1 22500113 1223981 Negative_regulation PGC DAZL 19865085 1983949 Negative_regulation PGC DND1 23773267 316802 Negative_regulation PGC DNMT3A 23029374 2696876 Negative_regulation PGC DNMT3B 23029374 2696877 Negative_regulation PGC DUSP1 20375469 27116 Negative_regulation PGC DUSP1 22415879 721800 Negative_regulation PGC DUSP1 22415879 722096 Negative_regulation PGC DUSP1 22415879 722252 Negative_regulation PGC DUSP1 22415879 722381 Negative_regulation PGC DUSP12 24152912 220956 Negative_regulation PGC EPS15 20532042 2452249 Negative_regulation PGC EPS8 20532042 2452250 Negative_regulation PGC ESRRA 24904222 491419 Negative_regulation PGC FBXO32 24478779 910965 Negative_regulation PGC FBXO32 25375380 578990 Negative_regulation PGC FIS1 22246294 1033615 Negative_regulation PGC FOXO1 25375380 579013 Negative_regulation PGC FOXO6 23639108 213489 Negative_regulation PGC FOXO6 23639108 213490 Negative_regulation PGC FOXO6 23639108 213491 Negative_regulation PGC FOXO6 23639108 213492 Negative_regulation PGC FOXO6 23639108 213500 Negative_regulation PGC FOXO6 23639108 213506 Negative_regulation PGC FOXO6 23639108 213507 Negative_regulation PGC FOXO6 23639108 213510 Negative_regulation PGC FOXO6 23639108 213517 Negative_regulation PGC FXN 20383327 2445900 Negative_regulation PGC GATA1 18974883 2399604 Negative_regulation PGC GATA2 18974883 2399605 Negative_regulation PGC GATA3 18974883 2399606 Negative_regulation PGC GATA4 18974883 2399607 Negative_regulation PGC GATA5 18974883 2399603 Negative_regulation PGC GATA6 18974883 2399608 Negative_regulation PGC GPS2 24492630 1940603 Negative_regulation PGC HDAC1 19366864 708288 Negative_regulation PGC HDAC1 23069623 724948 Negative_regulation PGC HDAC1 23861927 2820849 Negative_regulation PGC HDAC10 19366864 708286 Negative_regulation PGC HDAC11 19366864 708287 Negative_regulation PGC HDAC2 19366864 708289 Negative_regulation PGC HDAC2 23069623 724949 Negative_regulation PGC HDAC2 23861927 2820850 Negative_regulation PGC HDAC3 19366864 708290 Negative_regulation PGC HDAC3 24492630 1940604 Negative_regulation PGC HDAC4 19366864 708281 Negative_regulation PGC HDAC5 19366864 708285 Negative_regulation PGC HDAC5 24027504 861019 Negative_regulation PGC HDAC6 19366864 708282 Negative_regulation PGC HDAC7 19366864 708284 Negative_regulation PGC HDAC8 19366864 708280 Negative_regulation PGC HDAC9 19366864 708283 Negative_regulation PGC HIST1H3H 24322296 2096596 Negative_regulation PGC HK3 21072205 2481392 Negative_regulation PGC HTT 18464922 3072319 Negative_regulation PGC HTT 21211002 1891838 Negative_regulation PGC HTT 22071633 553438 Negative_regulation PGC HTT 24093018 858701 Negative_regulation PGC INS 18274626 3071729 Negative_regulation PGC INS 19366863 708263 Negative_regulation PGC INS 20936117 3075626 Negative_regulation PGC INS 21629705 1155257 Negative_regulation PGC INS 22590537 2641105 Negative_regulation PGC INS 22590537 2641149 Negative_regulation PGC INS 22590537 2641171 Negative_regulation PGC INS 23639108 213501 Negative_regulation PGC INS 24086476 2854338 Negative_regulation PGC KLF15 24167585 2872279 Negative_regulation PGC MAP2K1 18596912 3074274 Negative_regulation PGC MAP2K2 18596912 3074275 Negative_regulation PGC MAP2K3 18596912 3074276 Negative_regulation PGC MAP2K3 24843073 2252127 Negative_regulation PGC MAP2K4 18596912 3074277 Negative_regulation PGC MAP2K5 18596912 3074278 Negative_regulation PGC MAP2K6 18596912 3074279 Negative_regulation PGC MAP2K6 24843073 2252128 Negative_regulation PGC MAP2K7 18596912 3074280 Negative_regulation PGC MAPK1 23050972 89641 Negative_regulation PGC MAPK10 23050972 89642 Negative_regulation PGC MAPK11 23050972 89643 Negative_regulation PGC MAPK12 23050972 89644 Negative_regulation PGC MAPK13 23050972 89645 Negative_regulation PGC MAPK14 23050972 89646 Negative_regulation PGC MAPK15 23050972 89640 Negative_regulation PGC MAPK3 23050972 89647 Negative_regulation PGC MAPK4 23050972 89648 Negative_regulation PGC MAPK6 23050972 89649 Negative_regulation PGC MAPK7 23050972 89650 Negative_regulation PGC MAPK8 23050972 89651 Negative_regulation PGC MAPK9 23050972 89652 Negative_regulation PGC MYLIP 24086656 2855437 Negative_regulation PGC NA 24843073 2252131 Negative_regulation PGC NAMPT 25566462 1498446 Negative_regulation PGC NCOR1 24492630 1940605 Negative_regulation PGC NCOR2 24492630 1940606 Negative_regulation PGC NR0B1 16314306 2018576 Negative_regulation PGC NRD1 24492630 1940607 Negative_regulation PGC NRD1 24492630 1940608 Negative_regulation PGC NRIP1 22548174 1155565 Negative_regulation PGC POU5F1 21547058 1057110 Negative_regulation PGC PPARA 18952837 707132 Negative_regulation PGC PPARA 24086613 2855020 Negative_regulation PGC PREP 20864515 716599 Negative_regulation PGC PREP 23873833 701885 Negative_regulation PGC PRKAA1 18974883 2399645 Negative_regulation PGC PRKAA1 18974883 2399678 Negative_regulation PGC PRKAA1 20383170 9847 Negative_regulation PGC PRKAA1 20383327 2445875 Negative_regulation PGC PRKAA1 22359576 2597757 Negative_regulation PGC PRKAA1 22829833 1068709 Negative_regulation PGC PRKAA1 24843073 2252121 Negative_regulation PGC PRKAA1 24843073 2252139 Negative_regulation PGC PRKAA1 24843413 1493130 Negative_regulation PGC PRKAA2 18974883 2399646 Negative_regulation PGC PRKAA2 18974883 2399679 Negative_regulation PGC PRKAA2 20383170 9848 Negative_regulation PGC PRKAA2 20383327 2445876 Negative_regulation PGC PRKAA2 22359576 2597758 Negative_regulation PGC PRKAA2 22829833 1068710 Negative_regulation PGC PRKAA2 24843073 2252122 Negative_regulation PGC PRKAA2 24843073 2252140 Negative_regulation PGC PRKAA2 24843413 1493131 Negative_regulation PGC PRKAB1 18974883 2399647 Negative_regulation PGC PRKAB1 18974883 2399680 Negative_regulation PGC PRKAB1 20383170 9849 Negative_regulation PGC PRKAB1 20383327 2445877 Negative_regulation PGC PRKAB1 22359576 2597759 Negative_regulation PGC PRKAB1 22829833 1068711 Negative_regulation PGC PRKAB1 24843073 2252123 Negative_regulation PGC PRKAB1 24843073 2252141 Negative_regulation PGC PRKAB1 24843413 1493132 Negative_regulation PGC PRKAB2 18974883 2399648 Negative_regulation PGC PRKAB2 18974883 2399681 Negative_regulation PGC PRKAB2 20383170 9850 Negative_regulation PGC PRKAB2 20383327 2445878 Negative_regulation PGC PRKAB2 22359576 2597760 Negative_regulation PGC PRKAB2 22829833 1068712 Negative_regulation PGC PRKAB2 24843073 2252124 Negative_regulation PGC PRKAB2 24843073 2252142 Negative_regulation PGC PRKAB2 24843413 1493133 Negative_regulation PGC PRKACB 24733293 2952819 Negative_regulation PGC PRKACG 24733293 2952820 Negative_regulation PGC PRKAG1 18974883 2399649 Negative_regulation PGC PRKAG1 18974883 2399682 Negative_regulation PGC PRKAG1 20383170 9851 Negative_regulation PGC PRKAG1 20383327 2445879 Negative_regulation PGC PRKAG1 22359576 2597761 Negative_regulation PGC PRKAG1 22829833 1068713 Negative_regulation PGC PRKAG1 24843073 2252125 Negative_regulation PGC PRKAG1 24843073 2252143 Negative_regulation PGC PRKAG1 24843413 1493134 Negative_regulation PGC PRKAG2 18974883 2399650 Negative_regulation PGC PRKAG2 18974883 2399683 Negative_regulation PGC PRKAG2 20383170 9852 Negative_regulation PGC PRKAG2 20383327 2445880 Negative_regulation PGC PRKAG2 22359576 2597762 Negative_regulation PGC PRKAG2 22829833 1068714 Negative_regulation PGC PRKAG2 24843073 2252126 Negative_regulation PGC PRKAG2 24843073 2252144 Negative_regulation PGC PRKAG2 24843413 1493135 Negative_regulation PGC PRKAR1A 24733293 2952821 Negative_regulation PGC PRKAR1B 24733293 2952822 Negative_regulation PGC PRKAR2A 24733293 2952823 Negative_regulation PGC PRKAR2B 24733293 2952824 Negative_regulation PGC RB1 23895241 213847 Negative_regulation PGC RBBP4 23069623 724950 Negative_regulation PGC RBBP4 23861927 2820851 Negative_regulation PGC RBBP7 23069623 724951 Negative_regulation PGC RBBP7 23861927 2820852 Negative_regulation PGC RBL1 20713602 1378400 Negative_regulation PGC RBL1 20713602 1378406 Negative_regulation PGC RNF19A 24843073 2252120 Negative_regulation PGC RPS6KA5 21493629 1033389 Negative_regulation PGC SCD 18952837 707131 Negative_regulation PGC SETD2 21113404 3075679 Negative_regulation PGC SIRT1 21483036 29428 Negative_regulation PGC SIRT1 22096235 2069567 Negative_regulation PGC SIRT1 22096235 2069574 Negative_regulation PGC SIRT1 22548174 1155559 Negative_regulation PGC SIRT1 23874150 2283664 Negative_regulation PGC SIRT1 23874150 2283740 Negative_regulation PGC SIRT1 25192192 2245335 Negative_regulation PGC SIRT1 25465468 3094900 Negative_regulation PGC SIRT1 25566433 1498392 Negative_regulation PGC SIRT3 20157566 25934 Negative_regulation PGC SIRT3 20661474 2456756 Negative_regulation PGC SLC6A4 21493629 1033416 Negative_regulation PGC SOD1 18464922 3072303 Negative_regulation PGC SOD1 18487450 705967 Negative_regulation PGC SOD1 18487450 705974 Negative_regulation PGC TAF4 22288011 2009378 Negative_regulation PGC TANK 23342071 2741965 Negative_regulation PGC TBL1X 24492630 1940600 Negative_regulation PGC TBL1XR1 24492630 1940602 Negative_regulation PGC TCF12 18274626 3071718 Negative_regulation PGC TCF12 23242154 1099987 Negative_regulation PGC TCF15 18274626 3071719 Negative_regulation PGC TCF15 23242154 1099988 Negative_regulation PGC TCF19 18274626 3071720 Negative_regulation PGC TCF19 23242154 1099989 Negative_regulation PGC TCF20 18274626 3071721 Negative_regulation PGC TCF20 23242154 1099990 Negative_regulation PGC TCF21 18274626 3071722 Negative_regulation PGC TCF21 23242154 1099991 Negative_regulation PGC TCF23 18274626 3071726 Negative_regulation PGC TCF23 23242154 1099995 Negative_regulation PGC TCF24 18274626 3071728 Negative_regulation PGC TCF24 23242154 1099997 Negative_regulation PGC TCF25 18274626 3071727 Negative_regulation PGC TCF25 23242154 1099996 Negative_regulation PGC TCF3 18274626 3071723 Negative_regulation PGC TCF3 23242154 1099992 Negative_regulation PGC TCF4 18274626 3071724 Negative_regulation PGC TCF4 23242154 1099993 Negative_regulation PGC TCF7 18274626 3071725 Negative_regulation PGC TCF7 23242154 1099994 Negative_regulation PGC TGM2 20665636 774903 Negative_regulation PGC TNF 21234613 3302 Negative_regulation PGC TNF 24898700 1483517 Negative_regulation PGC TNF 24898700 1483521 Negative_regulation PGC TNFRSF12A 23342071 2741966 Negative_regulation PGC TNFRSF12A 23342071 2741981 Negative_regulation PGC TNFRSF12A 23342071 2741986 Negative_regulation PGC TNFSF12 23342071 2741980 Negative_regulation PGC TNFSF12 23342071 2741983 Negative_regulation PGC TNFSF12 23342071 2741984 Negative_regulation PGC TNFSF12 23342071 2741985 Negative_regulation PGC TNFSF12 23342071 2741995 Negative_regulation PGC TNFSF12 23342071 2741997 Negative_regulation PGC TNFSF12 23342071 2741998 Negative_regulation PGC TNFSF12 23835416 3163174 Negative_regulation PGC TNFSF12 23835416 3163175 Negative_regulation PGC TNFSF12 23835416 3163178 Negative_regulation PGC TNFSF12 23835416 3163179 Negative_regulation PGC TNFSF12 23835416 3163181 Negative_regulation PGC TNFSF12 24478779 910960 Negative_regulation PGC TNFSF12 24478779 910963 Negative_regulation PGC TNFSF12 24478779 910982 Negative_regulation PGC TNFSF12 24692845 1757843 Negative_regulation PGC TP53 23954639 590364 Negative_regulation PGC TP53 24472138 1727087 Negative_regulation PGC TP53 24563217 3081691 Negative_regulation PGC TP53 25375139 3023243 Negative_regulation PGC TRAF2 23342071 2741999 Negative_regulation PGC TRIM63 24478779 910964 Negative_regulation PGC TRPV4 23895241 213832 Negative_regulation PGC TWIST1 23093952 3075995 Negative_regulation PGC TWIST1 23093952 3076031 Negative_regulation PGC UCP1 22649390 875125 Negative_regulation PGC USF1 18974883 2399643 Negative_regulation PGC UTRN 24447845 3163265 Negative_regulation PGC WNT1 23469192 2763112 Negative_regulation PGC WNT11 23469192 2763113 Negative_regulation PGC WNT16 23469192 2763118 Negative_regulation PGC WNT2 23469192 2763114 Negative_regulation PGC WNT3 23469192 2763115 Negative_regulation PGC WNT4 23469192 2763116 Negative_regulation PGC WNT6 23469192 2763117 Negative_regulation PGC ZNF746 21708898 739043 Negative_regulation PGC ZNF746 21708898 739044 Negative_regulation PGC ZNF746 23304112 3076140 Negative_regulation PGC ZNF746 24223584 3076835 Negative_regulation PGC ZNF746 24935484 2221952 Negative_regulation PGC ZNF746 25099937 2995776 Negative_regulation PGC ZNF746 25548534 842542 Negative_regulation PGF ARSA 24672263 650222 Negative_regulation PGF TLR7 21176181 3099689 Negative_regulation PGLYRP4 LCK 22413885 355299 Negative_regulation PGM1 S100B 20672003 512959 Negative_regulation PGM1 S100B 20827422 513055 Negative_regulation PGM2 S100B 20672003 512960 Negative_regulation PGM2 S100B 20827422 513057 Negative_regulation PGM3 S100B 20672003 512961 Negative_regulation PGM3 S100B 20827422 513059 Negative_regulation PGM5 S100B 20672003 512962 Negative_regulation PGM5 S100B 20827422 513061 Negative_regulation PGP TNF 19176219 92160 Negative_regulation PGP TNF 20300455 1214085 Negative_regulation PGP TNFSF10 20663232 1857136 Negative_regulation PGP TNFSF10 20663232 1857178 Negative_regulation PGP TNFSF10 25276252 3085795 Negative_regulation PGR CCND1 24575359 86188 Negative_regulation PGR NR2F1 24212637 497869 Negative_regulation PHB MAP2K6 24096434 93507 Negative_regulation PHKA2 EPHB2 22096562 2571719 Negative_regulation PI15 LBP 24743550 3066757 Negative_regulation PI16 LBP 24743550 3066754 Negative_regulation PI3 CTGF 19152120 1478371 Negative_regulation PI3 EPHB2 23776078 1572547 Negative_regulation PI3 LBP 24743550 3066758 Negative_regulation PI3 MAP2K6 19924283 2431588 Negative_regulation PI3 MAP2K6 20041180 2435782 Negative_regulation PI3 MAP2K6 24031151 3230669 Negative_regulation PI3 TNF 24172336 410772 Negative_regulation PIGR EPHB2 21451502 1918227 Negative_regulation PIGR EPHB2 21451502 1918350 Negative_regulation PIGR EPHB2 21451502 1918353 Negative_regulation PIGR ERVK-6 20706611 1216013 Negative_regulation PIGR GRAP2 21451502 1918351 Negative_regulation PIGR MAPK1 21451502 1918411 Negative_regulation PIGR MAPK10 21451502 1918412 Negative_regulation PIGR MAPK11 21451502 1918413 Negative_regulation PIGR MAPK12 21451502 1918414 Negative_regulation PIGR MAPK13 21451502 1918415 Negative_regulation PIGR MAPK14 21451502 1918416 Negative_regulation PIGR MAPK15 21451502 1918410 Negative_regulation PIGR MAPK3 21451502 1918417 Negative_regulation PIGR MAPK4 21451502 1918418 Negative_regulation PIGR MAPK6 21451502 1918419 Negative_regulation PIGR MAPK7 21451502 1918420 Negative_regulation PIGR MAPK8 21451502 1918421 Negative_regulation PIGR MAPK9 21451502 1918422 Negative_regulation PIK3CA ANGPT1 23765731 3080562 Negative_regulation PIK3CA CAPN8 PMC2173748 1475009 Negative_regulation PIK3CA EPHB2 20225868 156613 Negative_regulation PIK3CA EPHB2 20712893 1858072 Negative_regulation PIK3CA EPHB2 20712893 1858129 Negative_regulation PIK3CA EPHB2 21048967 2480321 Negative_regulation PIK3CA EPHB2 21278786 2137738 Negative_regulation PIK3CA EPHB2 22566886 899588 Negative_regulation PIK3CA EPHB2 22675451 2648302 Negative_regulation PIK3CA EPHB2 23727661 218537 Negative_regulation PIK3CA EPHB2 23986484 1487081 Negative_regulation PIK3CA EPHB2 23986484 1487137 Negative_regulation PIK3CA EPHB2 23986484 1487138 Negative_regulation PIK3CA EPHB2 23986484 1487174 Negative_regulation PIK3CA EPHB2 24071646 566583 Negative_regulation PIK3CA FOXO1 21980390 2560042 Negative_regulation PIK3CA FOXO1 25157276 1240798 Negative_regulation PIK3CA INPP4B 25126743 2997989 Negative_regulation PIK3CA INPP4B 25126743 2997990 Negative_regulation PIK3CA ITGB2 21232086 1657677 Negative_regulation PIK3CA KANK4 18458160 1351891 Negative_regulation PIK3CA MAP2K6 20137073 1722969 Negative_regulation PIK3CA MAP2K6 20712893 1858079 Negative_regulation PIK3CA MAP2K6 20712893 1858136 Negative_regulation PIK3CA MAP2K6 22536370 2622136 Negative_regulation PIK3CA MAP2K6 23535559 1721096 Negative_regulation PIK3CA MAP2K6 24367624 2900396 Negative_regulation PIK3CA MAP2K6 24384723 570809 Negative_regulation PIK3CA MAP2K6 24413464 3139286 Negative_regulation PIK3CA MAP2K6 24810962 2190164 Negative_regulation PIK3CA MAP2K6 24810962 2190337 Negative_regulation PIK3CA MAP2K6 25344914 2206002 Negative_regulation PIK3CA MAP2K6 25344914 2206003 Negative_regulation PIK3CA PECAM1 20723025 1692093 Negative_regulation PIK3CA PECAM1 20723025 1692129 Negative_regulation PIK3CA SPHK1 20634980 2455671 Negative_regulation PIK3CA TCN1 19668232 2126327 Negative_regulation PIK3CA TLR7 24740015 2953926 Negative_regulation PIK3CA TM4SF19 25344917 2206156 Negative_regulation PIK3CA TSPAN1 10491398 1249581 Negative_regulation PIK3R1 ANGPT1 23765731 3080563 Negative_regulation PIK3R1 CAPN8 PMC2173748 1475023 Negative_regulation PIK3R1 EPHB2 20225868 156614 Negative_regulation PIK3R1 EPHB2 20712893 1858081 Negative_regulation PIK3R1 EPHB2 20712893 1858138 Negative_regulation PIK3R1 EPHB2 21048967 2480322 Negative_regulation PIK3R1 EPHB2 21278786 2137740 Negative_regulation PIK3R1 EPHB2 22566886 899589 Negative_regulation PIK3R1 EPHB2 22675451 2648303 Negative_regulation PIK3R1 EPHB2 23727661 218538 Negative_regulation PIK3R1 EPHB2 23986484 1487082 Negative_regulation PIK3R1 EPHB2 23986484 1487139 Negative_regulation PIK3R1 EPHB2 23986484 1487140 Negative_regulation PIK3R1 EPHB2 23986484 1487175 Negative_regulation PIK3R1 EPHB2 24071646 566587 Negative_regulation PIK3R1 FOXO1 21980390 2560046 Negative_regulation PIK3R1 FOXO1 25157276 1240799 Negative_regulation PIK3R1 INPP4B 25126743 2997991 Negative_regulation PIK3R1 INPP4B 25126743 2997992 Negative_regulation PIK3R1 ITGB2 21232086 1657678 Negative_regulation PIK3R1 KANK4 18458160 1351895 Negative_regulation PIK3R1 MAP2K6 20137073 1722976 Negative_regulation PIK3R1 MAP2K6 20712893 1858088 Negative_regulation PIK3R1 MAP2K6 20712893 1858145 Negative_regulation PIK3R1 MAP2K6 22536370 2622143 Negative_regulation PIK3R1 MAP2K6 23535559 1721103 Negative_regulation PIK3R1 MAP2K6 24367624 2900403 Negative_regulation PIK3R1 MAP2K6 24384723 570816 Negative_regulation PIK3R1 MAP2K6 24413464 3139293 Negative_regulation PIK3R1 MAP2K6 24810962 2190172 Negative_regulation PIK3R1 MAP2K6 24810962 2190349 Negative_regulation PIK3R1 MAP2K6 25344914 2206018 Negative_regulation PIK3R1 MAP2K6 25344914 2206019 Negative_regulation PIK3R1 PECAM1 20723025 1692094 Negative_regulation PIK3R1 PECAM1 20723025 1692130 Negative_regulation PIK3R1 SPHK1 20634980 2455672 Negative_regulation PIK3R1 TCN1 19668232 2126329 Negative_regulation PIK3R1 TLR7 24740015 2953936 Negative_regulation PIK3R1 TM4SF19 25344917 2206162 Negative_regulation PIK3R1 TSPAN1 10491398 1249603 Negative_regulation PIM1 CD14 21949737 2556421 Negative_regulation PIN1 TLR7 21743479 1955526 Negative_regulation PINK1 STK39 24244323 2879349 Negative_regulation PITX2 GJB2 23213439 168800 Negative_regulation PKD1 FHL1 24219103 151868 Negative_regulation PKD1 FHL1 24219103 151869 Negative_regulation PKD1 FHL1 24219103 152033 Negative_regulation PKD2 FHL1 24219103 151872 Negative_regulation PKD2 FHL1 24219103 151873 Negative_regulation PKD2 FHL1 24219103 152034 Negative_regulation PKD3 FHL1 24219103 151876 Negative_regulation PKD3 FHL1 24219103 151877 Negative_regulation PKD3 FHL1 24219103 152035 Negative_regulation PKLR CCND1 22751438 541621 Negative_regulation PKN1 MAP2K6 12732616 1292494 Negative_regulation PLA2G2A PLA2G4A 24391782 2904470 Negative_regulation PLA2G4A EPHB2 20403177 659563 Negative_regulation PLA2G4A MAP2K6 16048647 3105178 Negative_regulation PLA2G4A OXTR 22190926 1072859 Negative_regulation PLA2G4A PLA2G2A 24391782 2904471 Negative_regulation PLA2G4A TNF 24069158 2851515 Negative_regulation PLA2G4A TNF 24349530 2898437 Negative_regulation PLAGL1 ZFP57 23499433 850992 Negative_regulation PLAGL1 ZFP57 23499433 850997 Negative_regulation PLAGL1 ZFP57 23499433 850998 Negative_regulation PLAT ACLY 20425533 694235 Negative_regulation PLAT CPB2 23875049 2372002 Negative_regulation PLAT CRP 22244053 450742 Negative_regulation PLAT CTSG 20804552 1626136 Negative_regulation PLAT DLG4 23866919 1895814 Negative_regulation PLAT HCLS1 17576803 1341603 Negative_regulation PLAT HCLS1 17576803 1341637 Negative_regulation PLAT IL10 3491174 1583154 Negative_regulation PLAT IL11 3491174 1583155 Negative_regulation PLAT IL13 3491174 1583156 Negative_regulation PLAT IL15 3491174 1583157 Negative_regulation PLAT IL16 3491174 1583158 Negative_regulation PLAT IL18 3491174 1583159 Negative_regulation PLAT IL19 3491174 1583160 Negative_regulation PLAT IL1A 24827991 2969894 Negative_regulation PLAT IL2 3491174 1583161 Negative_regulation PLAT IL20 3491174 1583162 Negative_regulation PLAT IL21 3491174 1583163 Negative_regulation PLAT IL22 3491174 1583146 Negative_regulation PLAT IL24 3491174 1583144 Negative_regulation PLAT IL25 3491174 1583145 Negative_regulation PLAT IL26 3491174 1583150 Negative_regulation PLAT IL27 3491174 1583151 Negative_regulation PLAT IL2RB 17576803 1341611 Negative_regulation PLAT IL3 3491174 1583164 Negative_regulation PLAT IL31 3491174 1583152 Negative_regulation PLAT IL32 3491174 1583149 Negative_regulation PLAT IL33 3491174 1583148 Negative_regulation PLAT IL34 3491174 1583153 Negative_regulation PLAT IL37 3491174 1583147 Negative_regulation PLAT IL4 3491174 1583165 Negative_regulation PLAT IL5 3491174 1583166 Negative_regulation PLAT IL6 3491174 1583167 Negative_regulation PLAT IL7 3491174 1583168 Negative_regulation PLAT IL8 3491174 1583169 Negative_regulation PLAT IL9 3491174 1583170 Negative_regulation PLAT LEP 20671928 1747542 Negative_regulation PLAT LEP 21646388 719425 Negative_regulation PLAT LHCGR 23565150 2777025 Negative_regulation PLAT LRP1 23866919 1895800 Negative_regulation PLAT MAP6 10831618 1258179 Negative_regulation PLAT MAP6 25364620 1668527 Negative_regulation PLAT MAP6 25364620 1668528 Negative_regulation PLAT MAP6 25364620 1668531 Negative_regulation PLAT MAP6 25364620 1668532 Negative_regulation PLAT MAP6 25364620 1668533 Negative_regulation PLAT MSC 20140248 2440216 Negative_regulation PLAT NGFR 17576803 1341638 Negative_regulation PLAT PLAT 25368556 934401 Negative_regulation PLAT PLAU 22558080 2624244 Negative_regulation PLAT PLAU 23118509 1225503 Negative_regulation PLAT PLG 20158910 508108 Negative_regulation PLAT PLG 23118509 1225500 Negative_regulation PLAT PLG 23193360 1225608 Negative_regulation PLAT PLG 23936774 182547 Negative_regulation PLAT PLG 25386352 3092765 Negative_regulation PLAT RPL17 24383758 157138 Negative_regulation PLAT SERPINA1 22991657 627795 Negative_regulation PLAT SERPINA5 23118509 1225497 Negative_regulation PLAT SERPINB2 11044361 417976 Negative_regulation PLAT SERPINB2 16262900 3105749 Negative_regulation PLAT SERPINB2 21792312 454452 Negative_regulation PLAT SERPINE1 10725341 1256872 Negative_regulation PLAT SERPINE1 10817507 417098 Negative_regulation PLAT SERPINE1 10817507 417101 Negative_regulation PLAT SERPINE1 11044361 417975 Negative_regulation PLAT SERPINE1 14690546 507350 Negative_regulation PLAT SERPINE1 1721912 1336730 Negative_regulation PLAT SERPINE1 19171072 1625210 Negative_regulation PLAT SERPINE1 19997539 1709762 Negative_regulation PLAT SERPINE1 20140248 2440217 Negative_regulation PLAT SERPINE1 20140248 2440219 Negative_regulation PLAT SERPINE1 20407627 3208862 Negative_regulation PLAT SERPINE1 20532435 512567 Negative_regulation PLAT SERPINE1 21046291 665337 Negative_regulation PLAT SERPINE1 21281264 6580 Negative_regulation PLAT SERPINE1 21701678 2531349 Negative_regulation PLAT SERPINE1 21776339 1764516 Negative_regulation PLAT SERPINE1 21785728 1155320 Negative_regulation PLAT SERPINE1 21785728 1155329 Negative_regulation PLAT SERPINE1 21792312 454451 Negative_regulation PLAT SERPINE1 21998719 2562152 Negative_regulation PLAT SERPINE1 22069469 2569035 Negative_regulation PLAT SERPINE1 22096374 1628417 Negative_regulation PLAT SERPINE1 22384519 153551 Negative_regulation PLAT SERPINE1 22558080 2624243 Negative_regulation PLAT SERPINE1 22754528 951917 Negative_regulation PLAT SERPINE1 22892913 653325 Negative_regulation PLAT SERPINE1 22942700 1096969 Negative_regulation PLAT SERPINE1 22991657 627782 Negative_regulation PLAT SERPINE1 23047269 3125916 Negative_regulation PLAT SERPINE1 23145071 2715582 Negative_regulation PLAT SERPINE1 23173608 267060 Negative_regulation PLAT SERPINE1 23204984 684450 Negative_regulation PLAT SERPINE1 23573292 2778170 Negative_regulation PLAT SERPINE1 23573292 2778172 Negative_regulation PLAT SERPINE1 23751018 660434 Negative_regulation PLAT SERPINE1 23762501 1693188 Negative_regulation PLAT SERPINE1 23837050 843443 Negative_regulation PLAT SERPINE1 23890510 357403 Negative_regulation PLAT SERPINE1 23984168 515844 Negative_regulation PLAT SERPINE1 24009867 204109 Negative_regulation PLAT SERPINE1 24009867 204144 Negative_regulation PLAT SERPINE1 24124547 2866198 Negative_regulation PLAT SERPINE1 24130920 204443 Negative_regulation PLAT SERPINE1 24235858 1614618 Negative_regulation PLAT SERPINE1 24235858 1614626 Negative_regulation PLAT SERPINE1 24278711 3150247 Negative_regulation PLAT SERPINE1 24435163 512793 Negative_regulation PLAT SERPINE1 24465147 842087 Negative_regulation PLAT SERPINE1 24672668 1605751 Negative_regulation PLAT SERPINE1 24822208 190608 Negative_regulation PLAT SERPINE1 24825926 738436 Negative_regulation PLAT SERPINE1 24827991 2969895 Negative_regulation PLAT SERPINE1 24891849 1074250 Negative_regulation PLAT SERPINE1 25191587 1670073 Negative_regulation PLAT SERPINE1 25270030 1681526 Negative_regulation PLAT SERPINE1 25310015 3014949 Negative_regulation PLAT SERPINE1 25364620 1668529 Negative_regulation PLAT SERPINE1 25364620 1668530 Negative_regulation PLAT SERPINE1 25364620 1668534 Negative_regulation PLAT SERPINE1 25364620 1668535 Negative_regulation PLAT SERPINE1 25364620 1668536 Negative_regulation PLAT SERPINE1 PMC3837068 728980 Negative_regulation PLAT SERPINE2 25270030 1681527 Negative_regulation PLAT SERPINI1 18267959 1031635 Negative_regulation PLAT SERPINI1 18793432 310659 Negative_regulation PLAT SERPINI1 21569344 1697243 Negative_regulation PLAT SERPINI1 21569344 1697246 Negative_regulation PLAT SERPINI1 22654716 684389 Negative_regulation PLAT SERPINI1 23430930 937787 Negative_regulation PLAT SERPINI1 23658802 2790288 Negative_regulation PLAT SGTA 21975018 1892490 Negative_regulation PLAT SHH 23549381 1488972 Negative_regulation PLAT TFPI2 12147174 411419 Negative_regulation PLAT TFPI2 18053161 370958 Negative_regulation PLAT TGFB1 22162795 649969 Negative_regulation PLAT TIMP1 24718314 2950821 Negative_regulation PLAT TNF 18283548 86793 Negative_regulation PLAT TNFRSF1B 17576803 1341592 Negative_regulation PLAT TNFRSF1B 17576803 1341602 Negative_regulation PLAT TNFRSF1B 19225537 1719192 Negative_regulation PLAT VEGFA 20849640 389581 Negative_regulation PLAU AKT1 23597113 128341 Negative_regulation PLAU AKT2 23597113 128342 Negative_regulation PLAU AKT3 23597113 128343 Negative_regulation PLAU BRMS1 22356677 263640 Negative_regulation PLAU BSG 20824203 2473769 Negative_regulation PLAU BSG 22443116 264365 Negative_regulation PLAU BUD31 24505235 3177421 Negative_regulation PLAU CD44 23349823 2743382 Negative_regulation PLAU CDC42 20067638 255188 Negative_regulation PLAU CEBPA 18445634 2034434 Negative_regulation PLAU CRK 23597113 128339 Negative_regulation PLAU CTSB 10732768 416642 Negative_regulation PLAU CTSB 7547226 443892 Negative_regulation PLAU CTSB 8382511 444875 Negative_regulation PLAU CTSL 8382511 444876 Negative_regulation PLAU CXCL9 15617575 656481 Negative_regulation PLAU E2F1 23984088 1150953 Negative_regulation PLAU EDN2 8522616 1449755 Negative_regulation PLAU EGF 9744504 447912 Negative_regulation PLAU EGR1 15617575 656477 Negative_regulation PLAU EGR1 21283769 2498248 Negative_regulation PLAU EGR2 15617575 656478 Negative_regulation PLAU EGR3 15617575 656479 Negative_regulation PLAU EGR4 15617575 656480 Negative_regulation PLAU EPHB2 21798065 1505395 Negative_regulation PLAU EPHB2 23597113 128340 Negative_regulation PLAU EPHB2 23843896 3177322 Negative_regulation PLAU F2RL1 23905544 473632 Negative_regulation PLAU FGF2 20414463 1672162 Negative_regulation PLAU GDF9 23106040 647215 Negative_regulation PLAU HGF 22916069 1613809 Negative_regulation PLAU HRAS 10402467 1248047 Negative_regulation PLAU HRAS 23724131 2799110 Negative_regulation PLAU IGFBP3 24204158 2122329 Negative_regulation PLAU IL1RN 23597113 128196 Negative_regulation PLAU IL32 11259105 418488 Negative_regulation PLAU JUN 21798065 1505396 Negative_regulation PLAU JUN 22986534 2148780 Negative_regulation PLAU JUN 25200076 2104639 Negative_regulation PLAU KAT2B 23502002 2086231 Negative_regulation PLAU KRAS 23724131 2799111 Negative_regulation PLAU LBH 22172030 262890 Negative_regulation PLAU LRP1 8522616 1449756 Negative_regulation PLAU LRP1 8522616 1449757 Negative_regulation PLAU LRP10 8522616 1449748 Negative_regulation PLAU LRP10 8522616 1449749 Negative_regulation PLAU LRP11 8522616 1449750 Negative_regulation PLAU LRP11 8522616 1449751 Negative_regulation PLAU LRP12 8522616 1449753 Negative_regulation PLAU LRP12 8522616 1449754 Negative_regulation PLAU LRP2 8522616 1449758 Negative_regulation PLAU LRP2 8522616 1449759 Negative_regulation PLAU LRP3 8522616 1449760 Negative_regulation PLAU LRP3 8522616 1449761 Negative_regulation PLAU LRP4 8522616 1449762 Negative_regulation PLAU LRP4 8522616 1449763 Negative_regulation PLAU LRP5 8522616 1449764 Negative_regulation PLAU LRP5 8522616 1449765 Negative_regulation PLAU LRP6 8522616 1449766 Negative_regulation PLAU LRP6 8522616 1449767 Negative_regulation PLAU LRP8 8522616 1449768 Negative_regulation PLAU LRP8 8522616 1449769 Negative_regulation PLAU LRPAP1 11266465 1269124 Negative_regulation PLAU LRPAP1 8522616 1449707 Negative_regulation PLAU LRPAP1 8522616 1449708 Negative_regulation PLAU MAP2K1 10402467 1248048 Negative_regulation PLAU MAP2K1 21798065 1505397 Negative_regulation PLAU MAP2K2 21798065 1505398 Negative_regulation PLAU MAP2K3 21798065 1505399 Negative_regulation PLAU MAP2K4 21798065 1505400 Negative_regulation PLAU MAP2K5 21798065 1505401 Negative_regulation PLAU MAP2K6 21798065 1505402 Negative_regulation PLAU MAP2K7 21798065 1505403 Negative_regulation PLAU MAPK1 23349823 2743384 Negative_regulation PLAU MAPK1 23518876 2182685 Negative_regulation PLAU MAPK1 23724131 2799356 Negative_regulation PLAU MAPK10 23349823 2743385 Negative_regulation PLAU MAPK10 23518876 2182686 Negative_regulation PLAU MAPK10 23724131 2799357 Negative_regulation PLAU MAPK11 23349823 2743386 Negative_regulation PLAU MAPK11 23518876 2182687 Negative_regulation PLAU MAPK11 23724131 2799358 Negative_regulation PLAU MAPK12 23349823 2743387 Negative_regulation PLAU MAPK12 23518876 2182688 Negative_regulation PLAU MAPK12 23724131 2799359 Negative_regulation PLAU MAPK13 23349823 2743388 Negative_regulation PLAU MAPK13 23518876 2182689 Negative_regulation PLAU MAPK13 23724131 2799360 Negative_regulation PLAU MAPK14 23349823 2743389 Negative_regulation PLAU MAPK14 23518876 2182690 Negative_regulation PLAU MAPK14 23724131 2799361 Negative_regulation PLAU MAPK15 23349823 2743383 Negative_regulation PLAU MAPK15 23518876 2182684 Negative_regulation PLAU MAPK15 23724131 2799355 Negative_regulation PLAU MAPK3 23349823 2743390 Negative_regulation PLAU MAPK3 23518876 2182691 Negative_regulation PLAU MAPK3 23724131 2799362 Negative_regulation PLAU MAPK4 23349823 2743391 Negative_regulation PLAU MAPK4 23518876 2182692 Negative_regulation PLAU MAPK4 23724131 2799363 Negative_regulation PLAU MAPK6 23349823 2743392 Negative_regulation PLAU MAPK6 23518876 2182693 Negative_regulation PLAU MAPK6 23724131 2799364 Negative_regulation PLAU MAPK7 23349823 2743393 Negative_regulation PLAU MAPK7 23518876 2182694 Negative_regulation PLAU MAPK7 23724131 2799365 Negative_regulation PLAU MAPK8 23349823 2743394 Negative_regulation PLAU MAPK8 23518876 2182695 Negative_regulation PLAU MAPK8 23724131 2799366 Negative_regulation PLAU MAPK9 23349823 2743395 Negative_regulation PLAU MAPK9 23518876 2182696 Negative_regulation PLAU MAPK9 23724131 2799367 Negative_regulation PLAU MIEN1 19503095 2125546 Negative_regulation PLAU MIR23B 25192291 1129440 Negative_regulation PLAU MYLIP 23056551 2702262 Negative_regulation PLAU MYLIP 23459460 2342817 Negative_regulation PLAU MYLIP 23864708 1817004 Negative_regulation PLAU MYLIP 23864708 1817011 Negative_regulation PLAU MYLIP 24330766 1870576 Negative_regulation PLAU NFKB1 24213137 499587 Negative_regulation PLAU NOTCH1 22004682 1863734 Negative_regulation PLAU NOTCH1 22004682 1863735 Negative_regulation PLAU NOTCH2 22004682 1863736 Negative_regulation PLAU NOTCH3 22004682 1863737 Negative_regulation PLAU NOTCH4 22004682 1863738 Negative_regulation PLAU NRAS 23724131 2799112 Negative_regulation PLAU OXA1L 23864708 1817012 Negative_regulation PLAU PAF1 23502002 2086182 Negative_regulation PLAU PDCD4 25144746 3001242 Negative_regulation PLAU PIK3CA 17264880 2374610 Negative_regulation PLAU PIK3CA 17264880 2374619 Negative_regulation PLAU PIK3CA 23349823 2743396 Negative_regulation PLAU PIK3R1 17264880 2374611 Negative_regulation PLAU PIK3R1 17264880 2374620 Negative_regulation PLAU PIK3R1 23349823 2743397 Negative_regulation PLAU PLAT 23118509 1225505 Negative_regulation PLAU PLAUR 11257116 1267897 Negative_regulation PLAU PLAUR 19483730 2125494 Negative_regulation PLAU PLAUR 21535874 3207292 Negative_regulation PLAU PLAUR 24505235 3177422 Negative_regulation PLAU PLG 10206287 414199 Negative_regulation PLAU PLG 11556845 419889 Negative_regulation PLAU PLG 11953871 421540 Negative_regulation PLAU PLG 1661735 1328991 Negative_regulation PLAU PLG 23118509 1225501 Negative_regulation PLAU PLG 23936774 182548 Negative_regulation PLAU PLG 24129242 442092 Negative_regulation PLAU PPARA 18615182 3074312 Negative_regulation PLAU PRDX2 20609221 1856735 Negative_regulation PLAU PRDX2 20609221 1856746 Negative_regulation PLAU PRDX2 22291969 2591548 Negative_regulation PLAU RAC1 20067638 255189 Negative_regulation PLAU RELA 24213137 499588 Negative_regulation PLAU RPL17 24383758 157139 Negative_regulation PLAU SCN9A 23385179 2182202 Negative_regulation PLAU SERPINA5 23118509 1225498 Negative_regulation PLAU SERPINB2 11044361 417978 Negative_regulation PLAU SERPINB2 12617738 658454 Negative_regulation PLAU SERPINB2 1661735 1328990 Negative_regulation PLAU SERPINB2 19308679 495138 Negative_regulation PLAU SERPINB2 19442270 247671 Negative_regulation PLAU SERPINB2 2166055 1387621 Negative_regulation PLAU SERPINB2 21792312 454454 Negative_regulation PLAU SERPINB2 21800094 1991640 Negative_regulation PLAU SERPINB2 23118509 1225504 Negative_regulation PLAU SERPINB2 24129242 442091 Negative_regulation PLAU SERPINB2 24172014 1031449 Negative_regulation PLAU SERPINB2 24644264 492660 Negative_regulation PLAU SERPINB2 7947088 444496 Negative_regulation PLAU SERPINB2 9472634 446868 Negative_regulation PLAU SERPINE1 10098758 414093 Negative_regulation PLAU SERPINE1 10098758 414094 Negative_regulation PLAU SERPINE1 10390010 414596 Negative_regulation PLAU SERPINE1 10817495 417091 Negative_regulation PLAU SERPINE1 10817507 417099 Negative_regulation PLAU SERPINE1 11044361 417977 Negative_regulation PLAU SERPINE1 11250717 456442 Negative_regulation PLAU SERPINE1 11266468 1269203 Negative_regulation PLAU SERPINE1 11286474 418505 Negative_regulation PLAU SERPINE1 11437407 419165 Negative_regulation PLAU SERPINE1 11953898 421602 Negative_regulation PLAU SERPINE1 12615902 1526075 Negative_regulation PLAU SERPINE1 14761253 507353 Negative_regulation PLAU SERPINE1 16287709 1538356 Negative_regulation PLAU SERPINE1 16404434 426890 Negative_regulation PLAU SERPINE1 1661735 1328989 Negative_regulation PLAU SERPINE1 1721912 1336731 Negative_regulation PLAU SERPINE1 18452600 310055 Negative_regulation PLAU SERPINE1 18616803 251157 Negative_regulation PLAU SERPINE1 18922176 251684 Negative_regulation PLAU SERPINE1 18925475 1050810 Negative_regulation PLAU SERPINE1 19008962 2400777 Negative_regulation PLAU SERPINE1 19580651 659241 Negative_regulation PLAU SERPINE1 20407627 3208863 Negative_regulation PLAU SERPINE1 20976141 2479011 Negative_regulation PLAU SERPINE1 21701678 2531350 Negative_regulation PLAU SERPINE1 21789277 661411 Negative_regulation PLAU SERPINE1 21792312 454453 Negative_regulation PLAU SERPINE1 21800094 1991639 Negative_regulation PLAU SERPINE1 21966451 2558951 Negative_regulation PLAU SERPINE1 22131991 1673232 Negative_regulation PLAU SERPINE1 22276848 335758 Negative_regulation PLAU SERPINE1 22296682 263401 Negative_regulation PLAU SERPINE1 22447922 1492115 Negative_regulation PLAU SERPINE1 22470492 2614393 Negative_regulation PLAU SERPINE1 22496752 2617326 Negative_regulation PLAU SERPINE1 22659625 14868 Negative_regulation PLAU SERPINE1 22754528 951918 Negative_regulation PLAU SERPINE1 22802911 2219394 Negative_regulation PLAU SERPINE1 22933934 3092453 Negative_regulation PLAU SERPINE1 23097597 1225248 Negative_regulation PLAU SERPINE1 23145071 2715583 Negative_regulation PLAU SERPINE1 23536772 2771497 Negative_regulation PLAU SERPINE1 23762501 1693189 Negative_regulation PLAU SERPINE1 23951058 2833341 Negative_regulation PLAU SERPINE1 23951058 2833342 Negative_regulation PLAU SERPINE1 23951058 2833346 Negative_regulation PLAU SERPINE1 23984088 1150903 Negative_regulation PLAU SERPINE1 23984088 1151031 Negative_regulation PLAU SERPINE1 24120085 1667188 Negative_regulation PLAU SERPINE1 24129242 442090 Negative_regulation PLAU SERPINE1 24265642 3204661 Negative_regulation PLAU SERPINE1 24783193 189819 Negative_regulation PLAU SERPINE1 24822208 190609 Negative_regulation PLAU SERPINE1 25191587 1670074 Negative_regulation PLAU SERPINE1 2523891 1422897 Negative_regulation PLAU SERPINE1 25310015 3014950 Negative_regulation PLAU SERPINE1 3104349 1425787 Negative_regulation PLAU SERPINE1 8830783 1456545 Negative_regulation PLAU SERPINE1 8830783 1456559 Negative_regulation PLAU SERPINE1 9252196 446532 Negative_regulation PLAU SERPINE1 9472634 446859 Negative_regulation PLAU SERPINE1 9472634 446867 Negative_regulation PLAU SERPINE1 9472634 446874 Negative_regulation PLAU SERPINE1 9743288 447866 Negative_regulation PLAU SERPINE1 9743288 447867 Negative_regulation PLAU SERPINE1 9836475 447979 Negative_regulation PLAU SERPINE1 PMC4041408 745997 Negative_regulation PLAU SERPINE2 19951401 1020634 Negative_regulation PLAU SERPINI1 18793432 310660 Negative_regulation PLAU SETD2 24314144 222358 Negative_regulation PLAU SLC22A16 8522616 1449752 Negative_regulation PLAU SMAD4 20142997 481451 Negative_regulation PLAU SMAD4 23984088 1151025 Negative_regulation PLAU SMN1 23018346 1735669 Negative_regulation PLAU SRC 23843896 3177321 Negative_regulation PLAU ST14 23675430 2792860 Negative_regulation PLAU STAT1 24058752 1704852 Negative_regulation PLAU TCF12 23984088 1150943 Negative_regulation PLAU TCF15 23984088 1150944 Negative_regulation PLAU TCF19 23984088 1150945 Negative_regulation PLAU TCF20 23984088 1150946 Negative_regulation PLAU TCF21 23984088 1150947 Negative_regulation PLAU TCF23 23984088 1150951 Negative_regulation PLAU TCF24 23984088 1150954 Negative_regulation PLAU TCF25 23984088 1150952 Negative_regulation PLAU TCF3 23984088 1150948 Negative_regulation PLAU TCF4 23984088 1150949 Negative_regulation PLAU TCF7 23984088 1150950 Negative_regulation PLAU TEX101 25418358 174483 Negative_regulation PLAU TFPI 25222667 1730951 Negative_regulation PLAU TFPI 25222667 1730959 Negative_regulation PLAU TFPI2 18053161 370959 Negative_regulation PLAU TIMP1 23951091 2833413 Negative_regulation PLAU TIMP1 2465298 1417596 Negative_regulation PLAU TNFAIP8L2 24274578 1870372 Negative_regulation PLAU TNFAIP8L2 24274578 1870380 Negative_regulation PLAU TNFRSF6B 24107265 1870040 Negative_regulation PLAU TP53 25284615 1485298 Negative_regulation PLAU VIM 22792020 686360 Negative_regulation PLAUR EPHB2 19242538 2406263 Negative_regulation PLAUR EPHB2 19242538 2406266 Negative_regulation PLAUR EPHB2 23843896 3177324 Negative_regulation PLAUR PLAU 11257116 1267898 Negative_regulation PLAUR PLAU 19703758 1703363 Negative_regulation PLAUR PLAU 24505235 3177424 Negative_regulation PLAUR PLAU 9743521 1603809 Negative_regulation PLD1 SPHK1 21799019 1192607 Negative_regulation PLD1 TNF 22257771 3160831 Negative_regulation PLD2 SPHK1 21799019 1192609 Negative_regulation PLD3 SPHK1 21799019 1192599 Negative_regulation PLD4 SPHK1 21799019 1192601 Negative_regulation PLD5 SPHK1 21799019 1192603 Negative_regulation PLD6 SPHK1 21799019 1192605 Negative_regulation PLG F3 23118518 1225542 Negative_regulation PLG F3 23826213 2811567 Negative_regulation PLG PLAT 20931209 1072495 Negative_regulation PLG PLAT 21046291 665339 Negative_regulation PLG PLAT 22654716 684391 Negative_regulation PLG PLAT 23193360 1225609 Negative_regulation PLG PLAT 25520834 1630325 Negative_regulation PLG PLAU 10389993 414550 Negative_regulation PLG PLAU 10408848 414887 Negative_regulation PLG PLAU 10496354 415388 Negative_regulation PLG PLAU 10732775 416662 Negative_regulation PLG PLAU 11044361 417979 Negative_regulation PLG PLAU 11286474 418500 Negative_regulation PLG PLAU 11286474 418507 Negative_regulation PLG PLAU 16404434 426892 Negative_regulation PLG PLAU 17134505 312972 Negative_regulation PLG PLAU 18452600 310057 Negative_regulation PLG PLAU 1931618 431967 Negative_regulation PLG PLAU 20931209 1072496 Negative_regulation PLG PLAU 22276848 335761 Negative_regulation PLG PLAU 22991566 636949 Negative_regulation PLG PLAU 23701192 650473 Negative_regulation PLG PLAU 8297742 444688 Negative_regulation PLG PLAU 9192984 446382 Negative_regulation PLG PLAU 9303361 446601 Negative_regulation PLG PLAU 9635833 447096 Negative_regulation PLG PLAU 9635840 447106 Negative_regulation PLG PLAU 9652768 447286 Negative_regulation PLG PLAU 9743288 447862 Negative_regulation PLG PLAU 9743310 447900 Negative_regulation PLG PLAU 9836475 447980 Negative_regulation PLG PLAU PMC3272745 99443 Negative_regulation PLG PLAU PMC3850830 738732 Negative_regulation PLG TFPI2 18053161 370960 Negative_regulation PLG TFPI2 19759914 2426874 Negative_regulation PLG TFPI2 23497249 268031 Negative_regulation PLG TFPI2 23497249 268032 Negative_regulation PLG TNF 1714936 1543590 Negative_regulation PLG TNF 21773023 1669819 Negative_regulation PLG TNF 23423541 960830 Negative_regulation PLG TNF 23717597 2798464 Negative_regulation PLG TNF 24137243 843572 Negative_regulation PLG TNF 24744780 1074067 Negative_regulation PLG TNF 25110685 196163 Negative_regulation PLG TNF 25133669 2998732 Negative_regulation PLG TNF 3137305 1580326 Negative_regulation PLG TNF 8601593 1450646 Negative_regulation PLIN1 TNF 23740690 780974 Negative_regulation PLIN1 TNF 23781214 878823 Negative_regulation PLIN1 TNF 25325265 788386 Negative_regulation PLXNB1 EPHB2 19483722 2125452 Negative_regulation PLXNB1 EPHB2 19483722 2125453 Negative_regulation PLXNB1 EPHB2 19483722 2125470 Negative_regulation PNKD CCND1 23542180 218435 Negative_regulation PNLIP JAG1 23653565 2283034 Negative_regulation PNLIP JAG1 23653565 2283036 Negative_regulation PNOC MAP2K6 19390590 2415301 Negative_regulation PNPLA2 G0S2 23951308 2834129 Negative_regulation PODXL CD44 21342498 1861038 Negative_regulation PODXL LIMS1 21390327 2506428 Negative_regulation PODXL LIMS1 21390327 2506429 Negative_regulation PODXL LIMS1 21390327 2506439 Negative_regulation PODXL LIMS1 21390327 2506442 Negative_regulation PODXL TP53 19050011 2039113 Negative_regulation POLDIP2 EPHB2 23060802 959386 Negative_regulation POLDIP2 MAP2K6 25200404 3145374 Negative_regulation POLDIP2 TNF 16207331 104263 Negative_regulation POLDIP2 TNF 16207331 104264 Negative_regulation POMC EPHB2 19066310 707397 Negative_regulation POMC FOXO1 20020036 2434508 Negative_regulation POMC FOXO1 25343030 848249 Negative_regulation PON1 PLAU 22548179 1638934 Negative_regulation PON1 TNF 24124425 1685707 Negative_regulation POSTN JAG1 23166366 805574 Negative_regulation POT1 EPHB2 23360994 1934892 Negative_regulation POU2F3 EPHB2 25178105 1632722 Negative_regulation POU3F3 LINC00284 24936207 886414 Negative_regulation POU3F3 LINC00341 24936207 886374 Negative_regulation POU4F2 MAP2K6 21241485 467097 Negative_regulation POU5F1 ABCG2 23984394 183613 Negative_regulation POU5F1 EPHB2 23642364 615801 Negative_regulation POU5F1 TP63 24457968 571689 Negative_regulation PPARA FOXO1 17531095 2013465 Negative_regulation PPARA FOXO1 22152339 2112989 Negative_regulation PPARA TNF 15203881 830973 Negative_regulation PPARA TNF 24098322 2855797 Negative_regulation PPARA TNF 24466027 2912138 Negative_regulation PPARA TNF 24818164 1496418 Negative_regulation PPARA TNF 24818164 1496422 Negative_regulation PPARG FOXO1 21615920 397985 Negative_regulation PPARG FOXO1 22399922 3158682 Negative_regulation PPARG FOXO1 22510882 771779 Negative_regulation PPARG IL1B 20504330 329089 Negative_regulation PPAT FAS 23659636 89810 Negative_regulation PPBP IL6 23136963 412323 Negative_regulation PPBP IL6 23136963 412325 Negative_regulation PPBP IL6 23136963 412328 Negative_regulation PPBP IL6 23136963 412330 Negative_regulation PPBP IL6 23136963 412331 Negative_regulation PPBP TLR1 23136963 412314 Negative_regulation PPBP TLR1 23136963 412315 Negative_regulation PPBPP1 PPBP 25288925 2254567 Negative_regulation PPIF EPHB2 22675634 155182 Negative_regulation PPL TNF 16177180 2017694 Negative_regulation PPL TNF 16177180 2017701 Negative_regulation PPP1R12A OXTR 23948067 3102092 Negative_regulation PPP1R1B EPHB2 24204683 2873285 Negative_regulation PPP2CA EPHB2 19602257 385595 Negative_regulation PPP2CA EPHB2 19602257 385658 Negative_regulation PPP2CA EPHB2 23060802 959391 Negative_regulation PPP2R1A EPHB2 19602257 385597 Negative_regulation PPP2R1A EPHB2 19602257 385661 Negative_regulation PPP2R1A EPHB2 23060802 959392 Negative_regulation PPP2R2B EPHB2 19602257 385599 Negative_regulation PPP2R2B EPHB2 19602257 385664 Negative_regulation PPP2R2B EPHB2 23060802 959393 Negative_regulation PPP3CA RCAN1 19124655 1553389 Negative_regulation PPP3CA RCAN1 19458618 1983511 Negative_regulation PPP3CA RCAN1 19725972 1646658 Negative_regulation PPP3CA RCAN1 19725972 1646668 Negative_regulation PPP3CA RCAN1 19725972 1646685 Negative_regulation PPP3CA RCAN1 19860902 526169 Negative_regulation PPP3CA RCAN1 20145727 1065906 Negative_regulation PPP3CA RCAN1 20379369 1214257 Negative_regulation PPP3CA RCAN1 22397398 1661327 Negative_regulation PPP3CA RCAN1 22715383 2652769 Negative_regulation PPP3CA RCAN1 22848844 2002922 Negative_regulation PPP3CA RCAN1 23185487 2721139 Negative_regulation PPP3CA RCAN1 23825664 2809878 Negative_regulation PPP3CA RCAN1 24751678 2956072 Negative_regulation PPP3CB RCAN1 19458618 1983513 Negative_regulation PPP3CB RCAN1 19725972 1646669 Negative_regulation PPP3CB RCAN1 19725972 1646686 Negative_regulation PPP3CB RCAN1 19860902 526170 Negative_regulation PPP3CB RCAN1 23185487 2721140 Negative_regulation PPP3CB RCAN1 24751678 2956073 Negative_regulation PPP3CC RCAN1 19458618 1983515 Negative_regulation PPP3CC RCAN1 19725972 1646670 Negative_regulation PPP3CC RCAN1 19725972 1646687 Negative_regulation PPP3CC RCAN1 19860902 526171 Negative_regulation PPP3CC RCAN1 23185487 2721141 Negative_regulation PPP3CC RCAN1 24751678 2956074 Negative_regulation PPP3R1 RCAN1 19124655 1553390 Negative_regulation PPP3R1 RCAN1 19725972 1646659 Negative_regulation PPP3R1 RCAN1 20145727 1065907 Negative_regulation PPP3R1 RCAN1 20379369 1214258 Negative_regulation PPP3R1 RCAN1 22397398 1661328 Negative_regulation PPP3R1 RCAN1 22715383 2652770 Negative_regulation PPP3R1 RCAN1 22848844 2002923 Negative_regulation PPP3R1 RCAN1 23825664 2809879 Negative_regulation PPT1 FOXO1 21541341 2517039 Negative_regulation PRDM1 AXIN2 23335859 2281425 Negative_regulation PRDM8 HES2 19050759 2401680 Negative_regulation PRDX2 CCND1 16504004 1845104 Negative_regulation PRDX2 CCND1 16504004 1845174 Negative_regulation PRDX2 CCND1 16504004 1845181 Negative_regulation PRDX2 DAPK1 20048748 8910 Negative_regulation PRDX2 MMP28 22848731 2670257 Negative_regulation PRDX2 MMP7 22848731 2670272 Negative_regulation PREP PGC 20864515 716600 Negative_regulation PRG2 ADAMTS1 19445683 113329 Negative_regulation PRG2 F2R 24279676 856809 Negative_regulation PRG2 IGFBP1 15380039 101766 Negative_regulation PRG2 MMP28 18205922 109918 Negative_regulation PRG2 MMP28 22529468 1047492 Negative_regulation PRG2 MMP28 7629505 1591193 Negative_regulation PRG2 MMP7 18205922 109933 Negative_regulation PRG2 MMP7 22529468 1047507 Negative_regulation PRG2 MMP7 7629505 1591208 Negative_regulation PRG2 TNF 1730767 1337294 Negative_regulation PRG2 TNF 18001488 109436 Negative_regulation PRG2 TNF 19519926 113575 Negative_regulation PRG2 TNF 24458429 691981 Negative_regulation PRG3 ADAMTS1 19445683 113332 Negative_regulation PRG3 F2R 24279676 856810 Negative_regulation PRG3 IGFBP1 15380039 101775 Negative_regulation PRG3 MMP28 18205922 109940 Negative_regulation PRG3 MMP28 22529468 1047514 Negative_regulation PRG3 MMP28 7629505 1591215 Negative_regulation PRG3 MMP7 18205922 109955 Negative_regulation PRG3 MMP7 22529468 1047529 Negative_regulation PRG3 MMP7 7629505 1591230 Negative_regulation PRG3 TNF 1730767 1337295 Negative_regulation PRG3 TNF 18001488 109438 Negative_regulation PRG3 TNF 19519926 113576 Negative_regulation PRG3 TNF 24458429 691983 Negative_regulation PRG4 ADAMTS1 19445683 113335 Negative_regulation PRG4 F2R 24279676 856811 Negative_regulation PRG4 IGFBP1 15380039 101784 Negative_regulation PRG4 MMP28 18205922 109962 Negative_regulation PRG4 MMP28 22529468 1047536 Negative_regulation PRG4 MMP28 7629505 1591237 Negative_regulation PRG4 MMP7 18205922 109977 Negative_regulation PRG4 MMP7 22529468 1047551 Negative_regulation PRG4 MMP7 7629505 1591252 Negative_regulation PRG4 TNF 1730767 1337296 Negative_regulation PRG4 TNF 18001488 109440 Negative_regulation PRG4 TNF 19519926 113577 Negative_regulation PRG4 TNF 24458429 691985 Negative_regulation PRKAA1 CCND1 22194737 832312 Negative_regulation PRKAA1 EPHB2 22269797 1898943 Negative_regulation PRKAA1 EPHB2 22662165 2647131 Negative_regulation PRKAA1 FAS 23691481 478206 Negative_regulation PRKAA1 FAS 23770982 17957 Negative_regulation PRKAA1 FOXO1 21483870 2512483 Negative_regulation PRKAA1 TNF 25481457 3115133 Negative_regulation PRKAA2 CCND1 22194737 832313 Negative_regulation PRKAA2 EPHB2 22269797 1898946 Negative_regulation PRKAA2 EPHB2 22662165 2647132 Negative_regulation PRKAA2 FAS 23691481 478207 Negative_regulation PRKAA2 FAS 23770982 17959 Negative_regulation PRKAA2 FOXO1 21483870 2512485 Negative_regulation PRKAA2 TNF 25481457 3115134 Negative_regulation PRKAB1 CCND1 22194737 832314 Negative_regulation PRKAB1 EPHB2 22269797 1898949 Negative_regulation PRKAB1 EPHB2 22662165 2647133 Negative_regulation PRKAB1 FAS 23691481 478208 Negative_regulation PRKAB1 FAS 23770982 17961 Negative_regulation PRKAB1 FOXO1 21483870 2512487 Negative_regulation PRKAB1 TNF 25481457 3115135 Negative_regulation PRKAB2 CCND1 22194737 832315 Negative_regulation PRKAB2 EPHB2 22269797 1898952 Negative_regulation PRKAB2 EPHB2 22662165 2647134 Negative_regulation PRKAB2 FAS 23691481 478209 Negative_regulation PRKAB2 FAS 23770982 17963 Negative_regulation PRKAB2 FOXO1 21483870 2512489 Negative_regulation PRKAB2 TNF 25481457 3115136 Negative_regulation PRKACB CAPN8 23056924 140385 Negative_regulation PRKACB TNF 23071583 2703110 Negative_regulation PRKACB TNF 23082076 23916 Negative_regulation PRKACB TNF 23091522 1717470 Negative_regulation PRKACB TNF 24701420 86707 Negative_regulation PRKACG CAPN8 23056924 140399 Negative_regulation PRKACG TNF 23071583 2703111 Negative_regulation PRKACG TNF 23082076 23917 Negative_regulation PRKACG TNF 23091522 1717471 Negative_regulation PRKACG TNF 24701420 86708 Negative_regulation PRKAG1 CCND1 22194737 832316 Negative_regulation PRKAG1 EPHB2 22269797 1898955 Negative_regulation PRKAG1 EPHB2 22662165 2647135 Negative_regulation PRKAG1 FAS 23691481 478210 Negative_regulation PRKAG1 FAS 23770982 17965 Negative_regulation PRKAG1 FOXO1 21483870 2512491 Negative_regulation PRKAG1 TNF 25481457 3115137 Negative_regulation PRKAG2 CCND1 22194737 832317 Negative_regulation PRKAG2 EPHB2 22269797 1898958 Negative_regulation PRKAG2 EPHB2 22662165 2647136 Negative_regulation PRKAG2 FAS 23691481 478211 Negative_regulation PRKAG2 FAS 23770982 17967 Negative_regulation PRKAG2 FOXO1 21483870 2512493 Negative_regulation PRKAG2 TNF 25481457 3115138 Negative_regulation PRKAR1A CAPN8 23056924 140413 Negative_regulation PRKAR1A TNF 23071583 2703112 Negative_regulation PRKAR1A TNF 23082076 23918 Negative_regulation PRKAR1A TNF 23091522 1717472 Negative_regulation PRKAR1A TNF 24701420 86709 Negative_regulation PRKAR1B CAPN8 23056924 140427 Negative_regulation PRKAR1B TNF 23071583 2703113 Negative_regulation PRKAR1B TNF 23082076 23919 Negative_regulation PRKAR1B TNF 23091522 1717473 Negative_regulation PRKAR1B TNF 24701420 86710 Negative_regulation PRKAR2A CAPN8 23056924 140441 Negative_regulation PRKAR2A TNF 23071583 2703114 Negative_regulation PRKAR2A TNF 23082076 23920 Negative_regulation PRKAR2A TNF 23091522 1717474 Negative_regulation PRKAR2A TNF 24701420 86711 Negative_regulation PRKAR2B CAPN8 23056924 140455 Negative_regulation PRKAR2B TNF 23071583 2703115 Negative_regulation PRKAR2B TNF 23082076 23921 Negative_regulation PRKAR2B TNF 23091522 1717475 Negative_regulation PRKAR2B TNF 24701420 86712 Negative_regulation PRKCA IL1B 10704145 1737013 Negative_regulation PRKDC TNFSF10 21513580 1861782 Negative_regulation PRKDC TNFSF10 21513580 1861814 Negative_regulation PRL EPHB2 23708665 2152385 Negative_regulation PRL TNF 22470857 1044170 Negative_regulation PRNP FOXO1 23967259 2835434 Negative_regulation PROK1 CTGF 21098624 1035569 Negative_regulation PROM1 GPR87 23593389 2780808 Negative_regulation PROX1 EFNB1 22232059 3171874 Negative_regulation PRPH CAPN8 22252275 1230124 Negative_regulation PRPH NES 23675538 2793582 Negative_regulation PRS EDN2 23469133 2762014 Negative_regulation PSG1 SRGN 22754550 925102 Negative_regulation PSG11 SRGN 22754550 925103 Negative_regulation PSG2 SRGN 22754550 925104 Negative_regulation PSG3 SRGN 22754550 925105 Negative_regulation PSG4 SRGN 22754550 925106 Negative_regulation PSG5 SRGN 22754550 925107 Negative_regulation PSG6 SRGN 22754550 925108 Negative_regulation PSG7 SRGN 22754550 925109 Negative_regulation PSG8 SRGN 22754550 925110 Negative_regulation PSG9 SRGN 22754550 925111 Negative_regulation PTAFR F2R PMC2756345 495999 Negative_regulation PTBP1 ABCG2 25111504 2996283 Negative_regulation PTBP1 CD14 21687418 922233 Negative_regulation PTBP1 CD14 23076328 3217288 Negative_regulation PTBP1 EPHB2 20967853 135155 Negative_regulation PTBP1 EPHB2 22998978 1724989 Negative_regulation PTBP1 FAS 10523613 1512622 Negative_regulation PTBP1 HBEGF 22065991 2568215 Negative_regulation PTBP1 MAP2K6 18282094 3040939 Negative_regulation PTBP1 TLR7 18086320 109633 Negative_regulation PTBP1 TNF 21698207 2530804 Negative_regulation PTBP1 TNF 22279513 2219176 Negative_regulation PTBP1 TNF 25071777 913384 Negative_regulation PTBP1 TNF 25123797 368543 Negative_regulation PTBP1 TNF 9362532 1602035 Negative_regulation PTBP2 ABCG2 25111504 2996280 Negative_regulation PTBP2 CD14 21687418 922230 Negative_regulation PTBP2 CD14 23076328 3217276 Negative_regulation PTBP2 EPHB2 20967853 135152 Negative_regulation PTBP2 FAS 10523613 1512616 Negative_regulation PTBP2 HBEGF 22065991 2568212 Negative_regulation PTBP2 MAP2K6 18282094 3040918 Negative_regulation PTBP2 TLR7 18086320 109603 Negative_regulation PTBP2 TNF 21698207 2530801 Negative_regulation PTBP2 TNF 22279513 2219173 Negative_regulation PTBP2 TNF 25071777 913379 Negative_regulation PTBP2 TNF 25123797 368536 Negative_regulation PTBP2 TNF 9362532 1602032 Negative_regulation PTEN EPHB2 19881543 2127911 Negative_regulation PTEN EPHB2 19881543 2127976 Negative_regulation PTEN FOXO1 21980390 2560186 Negative_regulation PTEN FOXO1 23638435 943403 Negative_regulation PTEN TM4SF19 25344917 2206368 Negative_regulation PTGDR2 EPHB2 21364986 2504802 Negative_regulation PTGER2 HNRNPF 21444662 1563133 Negative_regulation PTGER2 HNRNPH1 21444662 1563134 Negative_regulation PTGER2 IL1A 25237386 1651016 Negative_regulation PTGER2 PTBP1 21444662 1563135 Negative_regulation PTGER2 PTBP2 21444662 1563132 Negative_regulation PTGER2 PTGER1 20939055 1237877 Negative_regulation PTGER2 PTGER4 23024463 1750601 Negative_regulation PTGER2 PTGS1 22022466 2563199 Negative_regulation PTGER2 SPAG11B 22654101 1203470 Negative_regulation PTGER4 PTGER2 23024463 1750603 Negative_regulation PTGER4 SLCO2A1 25505603 2248710 Negative_regulation PTGER4 SLCO2A1 25505603 2248711 Negative_regulation PTGES IL1B 15203568 1739641 Negative_regulation PTGES TNF 24198734 3155098 Negative_regulation PTGES TNF PMC2834086 134569 Negative_regulation PTGES3 STAT4 21738677 2533229 Negative_regulation PTGES3 TNF 21485744 734855 Negative_regulation PTGES3 ZFP57 25032857 577094 Negative_regulation PTGES3 ZFP57 25032857 577095 Negative_regulation PTGES3 ZFP57 25032857 577313 Negative_regulation PTGIS CRP 20425246 665327 Negative_regulation PTGS1 ALOX5 23770053 1498340 Negative_regulation PTGS1 ARSA 20529293 362675 Negative_regulation PTGS1 ARSA 22357572 412746 Negative_regulation PTGS1 ARSA 22920307 3204396 Negative_regulation PTGS1 ARSA 24604034 1045911 Negative_regulation PTGS1 ARSA 25031541 1162568 Negative_regulation PTGS1 IL1B 9927229 1764292 Negative_regulation PTGS2 ALOX5 22785226 1918951 Negative_regulation PTGS2 ALOX5 24516658 2921373 Negative_regulation PTGS2 ARSA 23431005 726602 Negative_regulation PTGS2 EPHB2 19821775 1236723 Negative_regulation PTGS2 EPHB2 22140508 2574863 Negative_regulation PTGS2 EPHB2 25005778 297582 Negative_regulation PTGS2 IL1B 11200365 1737603 Negative_regulation PTGS2 RCAN1 22397398 1661324 Negative_regulation PTGS2 TLR7 25083184 1078079 Negative_regulation PTGS2 TNF 11375052 224813 Negative_regulation PTGS2 TNF 15175101 523620 Negative_regulation PTGS2 TNF 15266333 424820 Negative_regulation PTGS2 TNF 16702604 1540322 Negative_regulation PTGS2 TNF 20953381 1748550 Negative_regulation PTGS2 TNF 22359588 2597952 Negative_regulation PTGS2 TNF 23675573 944097 Negative_regulation PTGS2 TNF 23717114 1614110 Negative_regulation PTGS2 TNF 23717159 1614374 Negative_regulation PTGS2 TNF 24386004 825052 Negative_regulation PTGS2 TNF 24499158 2113953 Negative_regulation PTGS2 TNF 25314304 3015609 Negative_regulation PTH CDKN1C 19144108 389825 Negative_regulation PTHLH CDKN1C 19144108 389826 Negative_regulation PTHLH EPHB2 25003010 3092916 Negative_regulation PTP4A3 EPHB2 23929599 781842 Negative_regulation PTPN1 PECAM1 20041871 92233 Negative_regulation PTPN11 EPHB2 11956229 1280896 Negative_regulation PTPN11 EPHB2 25296975 2204279 Negative_regulation PTPN11 TLR7 22566885 899508 Negative_regulation PTPN12 EPHB2 22319531 1067175 Negative_regulation PTPN22 RNASE1 23921629 2092188 Negative_regulation PTPN22 RNASE7 23921629 2092196 Negative_regulation PTPN5 MAP2K6 24847227 861140 Negative_regulation PTPN6 TLR7 22566885 899518 Negative_regulation PTX3 ID1 24749110 1022602 Negative_regulation PTX3 TNF 23531541 1103872 Negative_regulation PTX4 TNF 23531541 1103858 Negative_regulation PYY TNF 21394207 2506558 Negative_regulation QRICH1 TNF 25574232 845563 Negative_regulation QRICH2 TNF 25574232 845564 Negative_regulation RAB31 AKT1 20332342 713548 Negative_regulation RAB31 AKT2 20332342 713549 Negative_regulation RAB31 AKT3 20332342 713550 Negative_regulation RAB31 GDI1 19414611 1365858 Negative_regulation RAB31 GDI1 21931684 2554095 Negative_regulation RAB31 GDI1 23140504 1997922 Negative_regulation RAB31 GDI1 23181198 589546 Negative_regulation RAB31 GDI2 19414611 1365859 Negative_regulation RAB31 GDI2 21931684 2554096 Negative_regulation RAB31 GDI2 23181198 589547 Negative_regulation RAB31 INS 19590752 2421190 Negative_regulation RAB31 MUC1 22792175 2661078 Negative_regulation RAB31 PARK7 23892275 18139 Negative_regulation RAB31 PARK7 23892275 18328 Negative_regulation RAB31 PARK7 23892275 18436 Negative_regulation RAB31 RASA1 24569479 753223 Negative_regulation RAB31 SLC2A4 19590752 2421189 Negative_regulation RAB31 TBC1D4 20332342 713547 Negative_regulation RAB5C TNF 24708540 167592 Negative_regulation RAB7A FOXO1 25247581 1130855 Negative_regulation RAB7A RAB31 24569479 753136 Negative_regulation RAB7A TNF 24708540 167595 Negative_regulation RAB8A HBEGF 24376523 2901077 Negative_regulation RAB9A TP63 9230071 1461521 Negative_regulation RAC1 CAPN8 PMC2185599 1475200 Negative_regulation RAC1 CCND1 24523791 1685715 Negative_regulation RAC1 EPHB2 22384148 2606820 Negative_regulation RAC1 EPHB2 23208503 2150181 Negative_regulation RAC1 EPHB2 25123138 1129038 Negative_regulation RAC1 MAP2K6 23208503 2150187 Negative_regulation RAC1 NES 25371063 2172003 Negative_regulation RAC1 WNT7A 24711502 1418815 Negative_regulation RAC2 CAPN8 PMC2185599 1475214 Negative_regulation RAC3 CAPN8 PMC2185599 1475228 Negative_regulation RAD50 CAPN8 23056924 140469 Negative_regulation RAD50 EPHB2 23360994 1934902 Negative_regulation RAET1E GP2 23056001 904472 Negative_regulation RAET1E GP5 23056001 904473 Negative_regulation RAET1E GP6 23056001 904471 Negative_regulation RAET1E GP9 23056001 904474 Negative_regulation RAF1 ANO1 24639373 492655 Negative_regulation RAF1 EPHB2 18335053 2387103 Negative_regulation RAF1 EPHB2 22748295 406388 Negative_regulation RAF1 EPHB2 23554907 2773656 Negative_regulation RAF1 FAS 22830020 1831465 Negative_regulation RAF1 MAP2K6 17958888 1242786 Negative_regulation RAF1 MAP2K6 23554907 2773662 Negative_regulation RAG1 EPHB2 21966541 2559636 Negative_regulation RAG1 FOXO1 22908014 903688 Negative_regulation RAG1 FOXO1 23878308 1572808 Negative_regulation RAG2 EPHB2 21966541 2559639 Negative_regulation RAG2 FOXO1 22908014 903689 Negative_regulation RAG2 FOXO1 23878308 1572813 Negative_regulation RANBP2 INPP4B 25126743 2998006 Negative_regulation RANBP9 EPHB2 23118896 2711933 Negative_regulation RANBP9 MAP2K6 23118896 2711939 Negative_regulation RANBP9 MMP28 23348590 559224 Negative_regulation RANBP9 MMP7 23348590 559239 Negative_regulation RANGAP1 IFI27 15037602 1307552 Negative_regulation RAP1A EFNB1 19001122 1359691 Negative_regulation RAP1A EPHB2 19001122 1359693 Negative_regulation RARB NCL 22693611 2650942 Negative_regulation RARB NCL 22693611 2650946 Negative_regulation RARB TIMP3 18798999 480584 Negative_regulation RARB TIMP3 19835597 1852137 Negative_regulation RASA3 CA2 9874690 1612995 Negative_regulation RASD1 ESR1 22053771 334351 Negative_regulation RASD1 MYLIP 22053771 334323 Negative_regulation RASSF1 TNF 24327924 1831664 Negative_regulation RB1 CCND1 20113529 1853287 Negative_regulation RB1 CCND1 20721988 774931 Negative_regulation RB1 CCND1 21347341 3051198 Negative_regulation RB1 CCND1 22404972 528333 Negative_regulation RB1 CCND1 23259795 1699219 Negative_regulation RB1 CCND1 23383271 2749827 Negative_regulation RB1 CCND1 24876129 758421 Negative_regulation RB1 CCND1 25490312 3148105 Negative_regulation RB1 EPHB2 24330646 412496 Negative_regulation RB1 IFI27 17092340 580178 Negative_regulation RB1 IFI27 20504359 1676884 Negative_regulation RB1 PECAM1 24548763 809525 Negative_regulation RB1 PIGR 24699841 1886376 Negative_regulation RB1 TNF 25206809 2005939 Negative_regulation RBBP4 ALOX5 25402609 2160664 Negative_regulation RBBP4 CCND1 17407548 1846388 Negative_regulation RBBP4 CCND1 23836985 2121438 Negative_regulation RBBP4 CLU 23362253 1206178 Negative_regulation RBBP4 CST6 19503093 2125527 Negative_regulation RBBP4 MMP28 15899037 103613 Negative_regulation RBBP4 MMP7 15899037 103629 Negative_regulation RBBP4 TLR7 22312110 1567103 Negative_regulation RBBP4 TNF 25136952 2999251 Negative_regulation RBBP4 TNFSF10 16930472 249686 Negative_regulation RBBP4 TNFSF10 21931726 2554265 Negative_regulation RBBP5 HES2 23849347 660513 Negative_regulation RBBP7 ALOX5 25402609 2160666 Negative_regulation RBBP7 CCND1 17407548 1846389 Negative_regulation RBBP7 CCND1 23836985 2121450 Negative_regulation RBBP7 CLU 23362253 1206179 Negative_regulation RBBP7 CST6 19503093 2125528 Negative_regulation RBBP7 MMP28 15899037 103638 Negative_regulation RBBP7 MMP7 15899037 103654 Negative_regulation RBBP7 TLR7 22312110 1567113 Negative_regulation RBBP7 TNF 25136952 2999252 Negative_regulation RBBP7 TNFSF10 16930472 249687 Negative_regulation RBBP7 TNFSF10 21931726 2554266 Negative_regulation RBCK1 TNF 23104095 1958283 Negative_regulation RBP4 TNF 21808585 1682048 Negative_regulation RBP4 TNF 23460908 2759687 Negative_regulation RCAN1 AKT1 19124655 1553303 Negative_regulation RCAN1 AKT2 19124655 1553304 Negative_regulation RCAN1 AKT3 19124655 1553305 Negative_regulation RCAN1 ATF6 22536506 154802 Negative_regulation RCAN1 HDAC3 25144594 3001097 Negative_regulation RCAN1 MAPK1 19124655 1553306 Negative_regulation RCAN1 MAPK10 19124655 1553307 Negative_regulation RCAN1 MAPK11 19124655 1553308 Negative_regulation RCAN1 MAPK12 19124655 1553309 Negative_regulation RCAN1 MAPK13 19124655 1553310 Negative_regulation RCAN1 MAPK14 19124655 1553311 Negative_regulation RCAN1 MAPK15 19124655 1553302 Negative_regulation RCAN1 MAPK3 19124655 1553312 Negative_regulation RCAN1 MAPK4 19124655 1553313 Negative_regulation RCAN1 MAPK6 19124655 1553314 Negative_regulation RCAN1 MAPK7 19124655 1553315 Negative_regulation RCAN1 MAPK8 19124655 1553316 Negative_regulation RCAN1 MAPK9 19124655 1553317 Negative_regulation RCAN1 PPP3CA 19458618 1983505 Negative_regulation RCAN1 PPP3CB 19458618 1983506 Negative_regulation RCAN1 PPP3CC 19458618 1983507 Negative_regulation RCAN1 SYK 19124655 1553301 Negative_regulation RECK MMP28 18665171 430797 Negative_regulation RECK MMP28 22419890 1059894 Negative_regulation RECK MMP7 18665171 430812 Negative_regulation RECK MMP7 22419890 1059909 Negative_regulation REL MAP2K6 20802521 2135546 Negative_regulation REL TNF 21915344 2553423 Negative_regulation REL TNF 24024170 3093433 Negative_regulation REL TNF 24024170 3093437 Negative_regulation RELA ARSA 24039842 2844900 Negative_regulation RELA ARSA 24039842 2844935 Negative_regulation RELA ARSA 24553063 2118528 Negative_regulation RELA GPR132 19602228 1897250 Negative_regulation RELA LBP 1380063 1528801 Negative_regulation RELA LBP 1380063 1528804 Negative_regulation RELA SPHK1 20634980 2455694 Negative_regulation RELA TLR7 23506673 1036644 Negative_regulation RELA TLR7 PMC2756345 495798 Negative_regulation RELA TM4SF19 25344917 2206168 Negative_regulation RELA TNF 18834508 583305 Negative_regulation RELA TNF 21539730 1626348 Negative_regulation RELA TNF 21706061 2140622 Negative_regulation RELA TNF 21810263 1659159 Negative_regulation RELA TNF 22375551 1230315 Negative_regulation RELA TNF 22787387 742503 Negative_regulation RELA TNF 23593011 2345223 Negative_regulation RELA TNF 23634661 1666614 Negative_regulation RELA TNF 23969857 564898 Negative_regulation RELA TNF 23976842 742714 Negative_regulation RELA TNF 24586568 2925506 Negative_regulation RELA TNF 8655581 1451890 Negative_regulation RELA TNF 9788890 798122 Negative_regulation RELA ZFP57 24294107 679718 Negative_regulation REN RASD1 21247419 376270 Negative_regulation RENBP LBP 23094016 2705933 Negative_regulation RET EPHB2 15769183 2257991 Negative_regulation RET EPHB2 22941289 15986 Negative_regulation RETN TNF 19473519 1227117 Negative_regulation RETN TNF 19473519 1227144 Negative_regulation RETN TNF 21603279 1670228 Negative_regulation RGMA UNC5B 19273616 1364468 Negative_regulation RGS16 BIK 21610730 1933112 Negative_regulation RGS16 CRY1 21610730 1933113 Negative_regulation RGS2 C5 21829669 2542256 Negative_regulation RGS2 EDN1 22802950 2663759 Negative_regulation RGS2 FLT3 23936658 1719155 Negative_regulation RGS2 TAC1 22802950 2663763 Negative_regulation RGS2 TAC3 22802950 2663764 Negative_regulation RGS2 TAC4 22802950 2663765 Negative_regulation RGS2 WNT1 23755177 2801638 Negative_regulation RGS2 WNT11 23755177 2801639 Negative_regulation RGS2 WNT16 23755177 2801644 Negative_regulation RGS2 WNT2 23755177 2801640 Negative_regulation RGS2 WNT3 23755177 2801641 Negative_regulation RGS2 WNT4 23755177 2801642 Negative_regulation RGS2 WNT6 23755177 2801643 Negative_regulation RGS4 S1PR3 22545125 2623740 Negative_regulation RGS9 EPHB2 21852966 933496 Negative_regulation RHEB FOXO1 22476916 1238820 Negative_regulation RHO CAPN8 PMC2185599 1475186 Negative_regulation RHO CTGF 23259677 856272 Negative_regulation RHO MMP28 21591259 776125 Negative_regulation RHO MMP7 21591259 776140 Negative_regulation RHO RGS2 24743392 2955252 Negative_regulation RHO RGS2 24743392 2955264 Negative_regulation RHO S1PR3 21304987 2502041 Negative_regulation RHO TNF 21731751 2532410 Negative_regulation RHOA ANGPT1 21858121 2546408 Negative_regulation RHOA ANGPT1 23253477 1401583 Negative_regulation RHOA CAPN8 21049044 2480557 Negative_regulation RHOA CCND1 22070920 1863889 Negative_regulation RHOA EPHB2 22593214 1803194 Negative_regulation RHOA EPHB2 24478700 858783 Negative_regulation RHOA EPHB2 24478700 858784 Negative_regulation RHOA EPHB2 24478700 858785 Negative_regulation RHOA EPHB2 24478700 858791 Negative_regulation RHOA EPHB2 24478700 858792 Negative_regulation RHOA FAS 18195107 1347906 Negative_regulation RHOA GAB3 21118992 1783646 Negative_regulation RHOA IFI27 23029392 2697153 Negative_regulation RHOA IFI27 23430223 477445 Negative_regulation RHOA IFI27 23459844 942374 Negative_regulation RHOA IFI27 25452716 872532 Negative_regulation RHOA IFI27 25452716 872544 Negative_regulation RHOA KANK4 18458160 1351885 Negative_regulation RHOA KANK4 18458160 1351886 Negative_regulation RHOA KANK4 18458160 1352007 Negative_regulation RHOA KANK4 18458160 1352008 Negative_regulation RHOA KANK4 18458160 1352097 Negative_regulation RHOA KANK4 18458160 1352105 Negative_regulation RHOA MAP2K6 20380881 1881306 Negative_regulation RHOA MAP2K6 22593214 1803201 Negative_regulation RHOA MMP28 20843370 1504491 Negative_regulation RHOA MMP7 20843370 1504506 Negative_regulation RHOA RGS16 25568667 987493 Negative_regulation RHOA SLC6A2 18509476 2389884 Negative_regulation RHOA TNF 21731751 2532412 Negative_regulation RHOA UNC5B 19273616 1364443 Negative_regulation RHOA UNC5B 19273616 1364469 Negative_regulation RICTOR EPHB2 24212825 498972 Negative_regulation RICTOR MAP2K6 22808163 2664880 Negative_regulation RICTOR MAP2K6 24212825 498978 Negative_regulation RICTOR TCN1 20489726 546886 Negative_regulation RIPK2 IL1B 22514692 2619729 Negative_regulation RIPK3 EPHB2 25352744 1917355 Negative_regulation RIPK3 EPHB2 25352744 1917356 Negative_regulation RIPK3 TNF 21921917 1987943 Negative_regulation RIT2 IL1B 10704145 1737010 Negative_regulation RN7SK RNASE1 17341462 2026613 Negative_regulation RNASE1 ABI1 19635124 357989 Negative_regulation RNASE1 ABI2 19635124 357990 Negative_regulation RNASE1 ABI3 19635124 357991 Negative_regulation RNASE1 ACE 20230186 3206588 Negative_regulation RNASE1 ALB 23275570 2083880 Negative_regulation RNASE1 ALB 24864241 191577 Negative_regulation RNASE1 APOBEC3G 17942420 2030952 Negative_regulation RNASE1 ATP8A2 18557814 1889237 Negative_regulation RNASE1 CA2 22561375 2074990 Negative_regulation RNASE1 CA2 22561375 2075064 Negative_regulation RNASE1 CD6 22216069 2219138 Negative_regulation RNASE1 COIL 23616925 169605 Negative_regulation RNASE1 DDT 18611280 372329 Negative_regulation RNASE1 DNASE1 21904627 2550572 Negative_regulation RNASE1 EIF2AK2 25521494 3187109 Negative_regulation RNASE1 GPER1 22216069 2219139 Negative_regulation RNASE1 HCL1 16682442 2020863 Negative_regulation RNASE1 HCL1 18367476 2033707 Negative_regulation RNASE1 HCL1 18586823 2034946 Negative_regulation RNASE1 HCL1 19813215 1693254 Negative_regulation RNASE1 HCL1 19929881 2254204 Negative_regulation RNASE1 HCL1 20498841 2450931 Negative_regulation RNASE1 HCL1 21267069 2495265 Negative_regulation RNASE1 HCL1 22022266 3054008 Negative_regulation RNASE1 HCL1 22857387 337116 Negative_regulation RNASE1 HCL1 23074118 3232957 Negative_regulation RNASE1 HCL1 23620288 2087144 Negative_regulation RNASE1 HCL1 23620288 2087200 Negative_regulation RNASE1 HCL1 23620288 2087236 Negative_regulation RNASE1 HCL1 24157833 2094704 Negative_regulation RNASE1 HCL2 16682442 2020864 Negative_regulation RNASE1 HCL2 18367476 2033708 Negative_regulation RNASE1 HCL2 18586823 2034947 Negative_regulation RNASE1 HCL2 19813215 1693255 Negative_regulation RNASE1 HCL2 19929881 2254205 Negative_regulation RNASE1 HCL2 20498841 2450932 Negative_regulation RNASE1 HCL2 21267069 2495266 Negative_regulation RNASE1 HCL2 22022266 3054009 Negative_regulation RNASE1 HCL2 22857387 337117 Negative_regulation RNASE1 HCL2 23074118 3232958 Negative_regulation RNASE1 HCL2 23620288 2087145 Negative_regulation RNASE1 HCL2 23620288 2087201 Negative_regulation RNASE1 HCL2 23620288 2087237 Negative_regulation RNASE1 HCL2 24157833 2094705 Negative_regulation RNASE1 HCL3 16682442 2020865 Negative_regulation RNASE1 HCL3 18367476 2033709 Negative_regulation RNASE1 HCL3 18586823 2034948 Negative_regulation RNASE1 HCL3 19813215 1693256 Negative_regulation RNASE1 HCL3 19929881 2254206 Negative_regulation RNASE1 HCL3 20498841 2450933 Negative_regulation RNASE1 HCL3 21267069 2495267 Negative_regulation RNASE1 HCL3 22022266 3054010 Negative_regulation RNASE1 HCL3 22857387 337118 Negative_regulation RNASE1 HCL3 23074118 3232959 Negative_regulation RNASE1 HCL3 23620288 2087146 Negative_regulation RNASE1 HCL3 23620288 2087202 Negative_regulation RNASE1 HCL3 23620288 2087238 Negative_regulation RNASE1 HCL3 24157833 2094706 Negative_regulation RNASE1 KCNH4 20137095 375055 Negative_regulation RNASE1 MATN1 25232538 873182 Negative_regulation RNASE1 MCOLN1 18084035 2032274 Negative_regulation RNASE1 MTTER 18033800 2031917 Negative_regulation RNASE1 NEB 21124832 2484168 Negative_regulation RNASE1 NEB 22307085 771432 Negative_regulation RNASE1 NEB 22718970 2078758 Negative_regulation RNASE1 NEB 22718970 2078770 Negative_regulation RNASE1 NEB 22718970 2078771 Negative_regulation RNASE1 NEB 23663360 343516 Negative_regulation RNASE1 NEB 24157833 2094707 Negative_regulation RNASE1 NEB 24157833 2094755 Negative_regulation RNASE1 NEB 24985467 3124915 Negative_regulation RNASE1 NEB 25144653 2361796 Negative_regulation RNASE1 NEB 25342225 3146258 Negative_regulation RNASE1 NOP10 21747919 2534329 Negative_regulation RNASE1 NOP10 21747919 2534572 Negative_regulation RNASE1 NOP14 21747919 2534331 Negative_regulation RNASE1 NOP14 21747919 2534574 Negative_regulation RNASE1 NOP16 21747919 2534333 Negative_regulation RNASE1 NOP16 21747919 2534576 Negative_regulation RNASE1 NOP2 21747919 2534335 Negative_regulation RNASE1 NOP2 21747919 2534578 Negative_regulation RNASE1 NOP56 21747919 2534330 Negative_regulation RNASE1 NOP56 21747919 2534573 Negative_regulation RNASE1 NOP58 21747919 2534334 Negative_regulation RNASE1 NOP58 21747919 2534577 Negative_regulation RNASE1 NOP9 21747919 2534332 Negative_regulation RNASE1 NOP9 21747919 2534575 Negative_regulation RNASE1 OPN1MW 18828922 247648 Negative_regulation RNASE1 P4HB 23949117 3136820 Negative_regulation RNASE1 PAEP 19336414 2043046 Negative_regulation RNASE1 PAEP 23066505 746901 Negative_regulation RNASE1 PCNA 21245041 2060000 Negative_regulation RNASE1 PRX 23949117 3136819 Negative_regulation RNASE1 PSMD1 23047679 1934443 Negative_regulation RNASE1 RRBP1 21747919 2534571 Negative_regulation RNASE1 RRBP1 23910895 3201975 Negative_regulation RNASE1 SLC25A1 17130163 2024233 Negative_regulation RNASE1 SLC25A1 23966905 938258 Negative_regulation RNASE1 SNORD50A 17033699 173335 Negative_regulation RNASE1 SNORD50A 20364043 736484 Negative_regulation RNASE1 SNORD50A 21694443 736889 Negative_regulation RNASE1 SNORD50A 21694443 736890 Negative_regulation RNASE1 SNORD50A 22960330 737270 Negative_regulation RNASE1 TNMD 18069884 2289628 Negative_regulation RNASE1 UNG 20717113 435785 Negative_regulation RNASE1 UTP15 17130163 2024238 Negative_regulation RNASE1 UTP18 17130163 2024236 Negative_regulation RNASE1 UTP20 17130163 2024234 Negative_regulation RNASE1 UTP23 17130163 2024239 Negative_regulation RNASE1 UTP3 17130163 2024237 Negative_regulation RNASE1 UTP6 17130163 2024235 Negative_regulation RNASE1 ZC3HAV1 21085668 2482909 Negative_regulation RNASE7 ABI1 19635124 358013 Negative_regulation RNASE7 ABI2 19635124 358014 Negative_regulation RNASE7 ABI3 19635124 358015 Negative_regulation RNASE7 ACE 20230186 3206596 Negative_regulation RNASE7 ALB 23275570 2083888 Negative_regulation RNASE7 ALB 24864241 191585 Negative_regulation RNASE7 APOBEC3G 17942420 2030960 Negative_regulation RNASE7 ATP8A2 18557814 1889245 Negative_regulation RNASE7 CA2 22561375 2074998 Negative_regulation RNASE7 CA2 22561375 2075072 Negative_regulation RNASE7 CD6 22216069 2219154 Negative_regulation RNASE7 COIL 23616925 169613 Negative_regulation RNASE7 DDT 18611280 372337 Negative_regulation RNASE7 EIF2AK2 25521494 3187117 Negative_regulation RNASE7 GPER1 22216069 2219155 Negative_regulation RNASE7 HCL1 16682442 2020887 Negative_regulation RNASE7 HCL1 18367476 2033731 Negative_regulation RNASE7 HCL1 18586823 2034970 Negative_regulation RNASE7 HCL1 19813215 1693278 Negative_regulation RNASE7 HCL1 19929881 2254228 Negative_regulation RNASE7 HCL1 20498841 2450955 Negative_regulation RNASE7 HCL1 21267069 2495289 Negative_regulation RNASE7 HCL1 22022266 3054032 Negative_regulation RNASE7 HCL1 22857387 337140 Negative_regulation RNASE7 HCL1 23074118 3232982 Negative_regulation RNASE7 HCL1 23620288 2087168 Negative_regulation RNASE7 HCL1 23620288 2087224 Negative_regulation RNASE7 HCL1 23620288 2087260 Negative_regulation RNASE7 HCL1 24157833 2094736 Negative_regulation RNASE7 HCL2 16682442 2020888 Negative_regulation RNASE7 HCL2 18367476 2033732 Negative_regulation RNASE7 HCL2 18586823 2034971 Negative_regulation RNASE7 HCL2 19813215 1693279 Negative_regulation RNASE7 HCL2 19929881 2254229 Negative_regulation RNASE7 HCL2 20498841 2450956 Negative_regulation RNASE7 HCL2 21267069 2495290 Negative_regulation RNASE7 HCL2 22022266 3054033 Negative_regulation RNASE7 HCL2 22857387 337141 Negative_regulation RNASE7 HCL2 23074118 3232983 Negative_regulation RNASE7 HCL2 23620288 2087169 Negative_regulation RNASE7 HCL2 23620288 2087225 Negative_regulation RNASE7 HCL2 23620288 2087261 Negative_regulation RNASE7 HCL2 24157833 2094737 Negative_regulation RNASE7 HCL3 16682442 2020889 Negative_regulation RNASE7 HCL3 18367476 2033733 Negative_regulation RNASE7 HCL3 18586823 2034972 Negative_regulation RNASE7 HCL3 19813215 1693280 Negative_regulation RNASE7 HCL3 19929881 2254230 Negative_regulation RNASE7 HCL3 20498841 2450957 Negative_regulation RNASE7 HCL3 21267069 2495291 Negative_regulation RNASE7 HCL3 22022266 3054034 Negative_regulation RNASE7 HCL3 22857387 337142 Negative_regulation RNASE7 HCL3 23074118 3232984 Negative_regulation RNASE7 HCL3 23620288 2087170 Negative_regulation RNASE7 HCL3 23620288 2087226 Negative_regulation RNASE7 HCL3 23620288 2087262 Negative_regulation RNASE7 HCL3 24157833 2094738 Negative_regulation RNASE7 KCNH4 20137095 375063 Negative_regulation RNASE7 MATN1 25232538 873190 Negative_regulation RNASE7 MCOLN1 18084035 2032282 Negative_regulation RNASE7 MTTER 18033800 2031925 Negative_regulation RNASE7 MYLIP 23469087 2761395 Negative_regulation RNASE7 NEB 21124832 2484176 Negative_regulation RNASE7 NEB 22307085 771440 Negative_regulation RNASE7 NEB 22718970 2078766 Negative_regulation RNASE7 NEB 22718970 2078786 Negative_regulation RNASE7 NEB 22718970 2078787 Negative_regulation RNASE7 NEB 23663360 343524 Negative_regulation RNASE7 NEB 24157833 2094739 Negative_regulation RNASE7 NEB 24157833 2094763 Negative_regulation RNASE7 NEB 24985467 3124923 Negative_regulation RNASE7 NEB 25144653 2361804 Negative_regulation RNASE7 NEB 25342225 3146266 Negative_regulation RNASE7 NOP10 21747919 2534385 Negative_regulation RNASE7 NOP10 21747919 2534664 Negative_regulation RNASE7 NOP14 21747919 2534387 Negative_regulation RNASE7 NOP14 21747919 2534666 Negative_regulation RNASE7 NOP16 21747919 2534389 Negative_regulation RNASE7 NOP16 21747919 2534668 Negative_regulation RNASE7 NOP2 21747919 2534391 Negative_regulation RNASE7 NOP2 21747919 2534670 Negative_regulation RNASE7 NOP56 21747919 2534386 Negative_regulation RNASE7 NOP56 21747919 2534665 Negative_regulation RNASE7 NOP58 21747919 2534390 Negative_regulation RNASE7 NOP58 21747919 2534669 Negative_regulation RNASE7 NOP9 21747919 2534388 Negative_regulation RNASE7 NOP9 21747919 2534667 Negative_regulation RNASE7 PAEP 19336414 2043054 Negative_regulation RNASE7 PAEP 23066505 746909 Negative_regulation RNASE7 PCNA 21245041 2060008 Negative_regulation RNASE7 PSMD1 23047679 1934451 Negative_regulation RNASE7 RRBP1 21747919 2534663 Negative_regulation RNASE7 RRBP1 23910895 3201995 Negative_regulation RNASE7 SLC25A1 17130163 2024289 Negative_regulation RNASE7 SLC25A1 23966905 938266 Negative_regulation RNASE7 SNORD50A 17033699 173343 Negative_regulation RNASE7 SNORD50A 20364043 736492 Negative_regulation RNASE7 SNORD50A 21694443 736905 Negative_regulation RNASE7 SNORD50A 21694443 736906 Negative_regulation RNASE7 SNORD50A 22960330 737278 Negative_regulation RNASE7 TNMD 18069884 2289636 Negative_regulation RNASE7 UNG 20717113 435793 Negative_regulation RNASE7 UTP15 17130163 2024294 Negative_regulation RNASE7 UTP18 17130163 2024292 Negative_regulation RNASE7 UTP20 17130163 2024290 Negative_regulation RNASE7 UTP23 17130163 2024295 Negative_regulation RNASE7 UTP3 17130163 2024293 Negative_regulation RNASE7 UTP6 17130163 2024291 Negative_regulation RNASE7 ZC3HAV1 21085668 2482917 Negative_regulation RND1 UNC5B 19492039 2417963 Negative_regulation RND3 OXTR 23948067 3102063 Negative_regulation RNF19A CD14 20011115 3045911 Negative_regulation RNF19A CHI3L1 19930630 507961 Negative_regulation RNF19A CTGF 19852794 1227665 Negative_regulation RNF19A CTGF 19852794 1227666 Negative_regulation RNF19A CTGF 23227240 2725724 Negative_regulation RNF19A EPHB2 17205106 1054711 Negative_regulation RNF19A EPHB2 21569377 1658368 Negative_regulation RNF19A EPHB2 22675451 2648406 Negative_regulation RNF19A EPHB2 23277279 610805 Negative_regulation RNF19A EPHB2 23577223 2225777 Negative_regulation RNF19A EPHB2 25423094 3029893 Negative_regulation RNF19A MAP2K6 24232636 2235865 Negative_regulation RNF19A PTGER2 25327961 216527 Negative_regulation RNF19A TNF 14613529 3095405 Negative_regulation RNF19A TNF 16207331 104230 Negative_regulation RNF19A TNF 16207331 104231 Negative_regulation RNF19A TNF 18404427 3087213 Negative_regulation RNF19A TNF 23277816 1710356 Negative_regulation RNF19A TNF 25364728 861723 Negative_regulation RNF2 HES2 23849347 660450 Negative_regulation RNMT CCND1 24419005 502744 Negative_regulation ROCK1 CCND1 20459741 1855034 Negative_regulation ROCK1 CCND1 22070920 1863887 Negative_regulation ROCK1 CTGF 23259677 856273 Negative_regulation ROCK1 EPHB2 24091658 566670 Negative_regulation ROCK1 EPHB2 25538140 1905518 Negative_regulation ROCK1 MAP2K6 20380881 1881288 Negative_regulation ROCK1 MAP2K6 22213560 3171772 Negative_regulation ROCK1 MAP2K6 22213560 3171773 Negative_regulation ROCK1 MAP2K6 22213560 3171813 Negative_regulation ROCK2 CCND1 20459741 1855036 Negative_regulation ROCK2 CCND1 22070920 1863888 Negative_regulation ROCK2 CTGF 23259677 856274 Negative_regulation ROCK2 EPHB2 24091658 566671 Negative_regulation ROCK2 EPHB2 25538140 1905520 Negative_regulation ROCK2 MAP2K6 20380881 1881297 Negative_regulation ROCK2 MAP2K6 22213560 3171786 Negative_regulation ROCK2 MAP2K6 22213560 3171787 Negative_regulation ROCK2 MAP2K6 22213560 3171820 Negative_regulation ROR1 TNFSF10 23497038 1666073 Negative_regulation ROR1 TNFSF10 23497038 1666091 Negative_regulation ROR2 TNFSF10 23497038 1666075 Negative_regulation ROR2 TNFSF10 23497038 1666093 Negative_regulation RORC AHR 22888330 903074 Negative_regulation RORC FOXP3 25621490 3038862 Negative_regulation RORC GATA3 25621490 3038861 Negative_regulation RORC IL6 21131965 1954682 Negative_regulation RORC NOS1 23797095 1572594 Negative_regulation RORC OR2T1 23924903 1632312 Negative_regulation RPL17 TNF 25438012 2234105 Negative_regulation RPL23 IFI27 23316135 866463 Negative_regulation RPS6 IFI27 25412313 579217 Negative_regulation RPS6KA1 MAP2K6 23826126 2810445 Negative_regulation RPTOR EPHB2 23077579 2704793 Negative_regulation RPTOR EPHB2 23077579 2704808 Negative_regulation RPTOR EPHB2 24212825 498980 Negative_regulation RPTOR EPHB2 24303063 2887899 Negative_regulation RPTOR FAS 18776140 706721 Negative_regulation RPTOR FAS 18776140 706725 Negative_regulation RPTOR FBXO32 24765525 847690 Negative_regulation RPTOR FOXO1 22870349 696215 Negative_regulation RPTOR FOXO1 22870349 696315 Negative_regulation RPTOR FOXO1 23614736 829979 Negative_regulation RPTOR FOXO1 23614736 830018 Negative_regulation RPTOR FOXO1 23800068 830074 Negative_regulation RPTOR FOXO1 23800068 830169 Negative_regulation RPTOR FOXO1 23800068 830170 Negative_regulation RPTOR FOXO1 23800068 830207 Negative_regulation RPTOR MAP2K6 23242584 477363 Negative_regulation RPTOR MAP2K6 24212825 498986 Negative_regulation RRBP1 RNASE1 23910895 3201980 Negative_regulation RRBP1 RNASE7 23910895 3201988 Negative_regulation RRM2B TP63 24823795 2100834 Negative_regulation RRM2B TP63 24823795 2100836 Negative_regulation RUNX1 EPHB2 24681962 219076 Negative_regulation RUNX1 TNF 23762085 637566 Negative_regulation RUNX2 CCND1 16984628 370107 Negative_regulation RUNX2 EPHB2 24531206 795212 Negative_regulation RUNX2 FOXO1 25187705 1138329 Negative_regulation RUNX2 IFI27 21197465 3127749 Negative_regulation RUNX2 MAP2K6 15226309 1310522 Negative_regulation RUNX2 TNF 22396737 2608368 Negative_regulation RUNX2 TNF 23762085 637567 Negative_regulation RUNX2 TNF 24743742 573718 Negative_regulation RUNX2 TNF 24743742 573719 Negative_regulation RUNX2 TNF 24743742 573906 Negative_regulation RUNX2 TNF 24743742 573936 Negative_regulation RUNX2 ZFP57 21173110 1383337 Negative_regulation RUNX2 ZFP57 21173110 1383338 Negative_regulation RUNX2 ZFP57 21173110 1383567 Negative_regulation RUNX2 ZFP57 21173110 1383568 Negative_regulation RUNX2 ZFP57 21173110 1383569 Negative_regulation RUNX2 ZFP57 21173110 1383651 Negative_regulation RUNX2 ZFP57 21173110 1383652 Negative_regulation RUNX2 ZFP57 21173110 1383717 Negative_regulation RUNX2 ZFP57 21173110 1383736 Negative_regulation RUNX2 ZFP57 21173110 1383999 Negative_regulation RUNX2 ZFP57 21539723 3168942 Negative_regulation RUNX2 ZFP57 23209378 2281008 Negative_regulation RUNX2 ZFP57 23569325 1571118 Negative_regulation RUNX2 ZFP57 23569325 1571473 Negative_regulation RUNX2 ZFP57 PMC3010066 1477637 Negative_regulation RUNX3 TNF 23762085 637568 Negative_regulation S100A10 RNASE1 23123427 85338 Negative_regulation S100A10 RNASE7 23123427 85346 Negative_regulation S100A12 MAP2K6 22742729 1899205 Negative_regulation S100A4 TNF 10389988 414540 Negative_regulation S100A7 BRCA1 24556685 572223 Negative_regulation S100A7 ICAM1 23300877 2736925 Negative_regulation S100A7 IFNG 17986321 250446 Negative_regulation S100A7 IFNG 17986321 250447 Negative_regulation S100A7 IFNG 17986321 250470 Negative_regulation S100A7 IFNG 17986321 250473 Negative_regulation S100A7 IL13 22230654 3112890 Negative_regulation S100A7 IL4 22230654 3112889 Negative_regulation S100A7 IL4 22230654 3112891 Negative_regulation S100A7 IL4 22230654 3112899 Negative_regulation S100A7 STAT1 17986321 250465 Negative_regulation S100A7 STAT1 17986321 250472 Negative_regulation S100B ADCY1 23164356 1895654 Negative_regulation S100B ADCY10 23164356 1895653 Negative_regulation S100B ADCY2 23164356 1895655 Negative_regulation S100B ADCY3 23164356 1895656 Negative_regulation S100B ADCY4 23164356 1895657 Negative_regulation S100B ADCY5 23164356 1895658 Negative_regulation S100B ADCY6 23164356 1895659 Negative_regulation S100B ADCY7 23164356 1895660 Negative_regulation S100B ADCY8 23164356 1895661 Negative_regulation S100B ADCY9 23164356 1895662 Negative_regulation S100B APP 19668572 649431 Negative_regulation S100B CDK2 25536222 3035753 Negative_regulation S100B CDKN1B 25536222 3035754 Negative_regulation S100B EGF 20827421 513034 Negative_regulation S100B EN1 17362503 299794 Negative_regulation S100B GCG 20672003 512953 Negative_regulation S100B GSN 21936896 1659750 Negative_regulation S100B HOXC11 21654685 436845 Negative_regulation S100B INS 18840784 707093 Negative_regulation S100B INS 20631894 512949 Negative_regulation S100B INS 20631894 512951 Negative_regulation S100B INS 20672003 512955 Negative_regulation S100B INS 23705829 395955 Negative_regulation S100B MOK 20672051 512977 Negative_regulation S100B NCOA1 21654685 436846 Negative_regulation S100B NOS1 25034944 1943556 Negative_regulation S100B NOS2 25034944 1943557 Negative_regulation S100B NOS3 25034944 1943558 Negative_regulation S100B TP53 23259641 1665801 Negative_regulation S100B TP53 23259641 1665804 Negative_regulation S100G IL1B 25049477 136121 Negative_regulation S1PR3 LPA 21936950 1697760 Negative_regulation S1PR3 RGS4 22545125 2623741 Negative_regulation S1PR3 SPHK1 21887342 2549367 Negative_regulation SAA1 IL6R 20374625 3091218 Negative_regulation SAA1 RAB31 21603208 632712 Negative_regulation SAA1 TNF 24651840 2937267 Negative_regulation SALL1 CAPN8 24394804 1940152 Negative_regulation SALL1 CAPN8 24394804 1940261 Negative_regulation SALL1 RNASE1 22438882 2611799 Negative_regulation SALL1 RNASE7 22438882 2611807 Negative_regulation SAT1 TNF 23193206 729965 Negative_regulation SCARA3 ADIPOQ 19875582 729353 Negative_regulation SCARB1 PDZK1 19169357 2404646 Negative_regulation SCARB1 PDZK1 23936087 2829386 Negative_regulation SCARB1 TNF 19284653 2232798 Negative_regulation SCARB1 TNF 21988829 1723915 Negative_regulation SCD TNF 19925655 327028 Negative_regulation SCG2 EDN2 21955788 405610 Negative_regulation SCG3 EDN2 21955788 405616 Negative_regulation SCG5 EDN2 21955788 405613 Negative_regulation SCIN MYLIP 24280866 1721954 Negative_regulation SCIN SEA 24963913 2983481 Negative_regulation SCIN SEPP1 24963913 2983482 Negative_regulation SCN5A FOXO1 22400069 2608773 Negative_regulation SCN5A FOXO1 23393573 2751213 Negative_regulation SCRIB EPHB2 23359326 2744887 Negative_regulation SEA SCIN 24963913 2983479 Negative_regulation SEC13 EPHB2 23342042 2741782 Negative_regulation SEC14L2 PRODH 20403182 393318 Negative_regulation SEC62 EPHB2 23342042 2741786 Negative_regulation SEC63 EPHB2 23342042 2741790 Negative_regulation SELE ANGPT1 19435476 659213 Negative_regulation SELE ANGPT1 24376824 2902373 Negative_regulation SELE HES2 24891765 1759453 Negative_regulation SELE PECAM1 9314541 1463955 Negative_regulation SELE SELL 1374413 1297879 Negative_regulation SELE SELL 7682218 1438769 Negative_regulation SELE TNF 22014750 211759 Negative_regulation SELE TNF 23029004 2694106 Negative_regulation SELE TNF 23533479 817794 Negative_regulation SELE TNF 23533479 817795 Negative_regulation SELE TNF 23770053 1498335 Negative_regulation SELE TNF 23929007 87353 Negative_regulation SELE TNF 8386742 1595101 Negative_regulation SELL ADAM17 24602331 660684 Negative_regulation SELL AKT1S1 23183047 1570078 Negative_regulation SELL APC 25268140 3011348 Negative_regulation SELL BCR 22888331 903154 Negative_regulation SELL CALM3 19823572 2268689 Negative_regulation SELL CD69 18000535 2380707 Negative_regulation SELL CD69 23658623 2789211 Negative_regulation SELL CD79A 22888331 903155 Negative_regulation SELL CD79B 22888331 903156 Negative_regulation SELL CSRP1 23324174 856584 Negative_regulation SELL CTLA4 23752227 1572492 Negative_regulation SELL DIO1 21298111 2499856 Negative_regulation SELL DIO2 21298111 2499857 Negative_regulation SELL DIO3 21298111 2499858 Negative_regulation SELL EDN1 18029384 90721 Negative_regulation SELL EGF 7543141 1590420 Negative_regulation SELL FOXP3 18998771 2265393 Negative_regulation SELL FOXP3 18998771 2265394 Negative_regulation SELL FOXP3 18998771 2265396 Negative_regulation SELL FUT4 14597733 1529402 Negative_regulation SELL FUT4 14597733 1529403 Negative_regulation SELL FUT4 14597733 1529417 Negative_regulation SELL FUT4 14597733 1529420 Negative_regulation SELL FUT7 14597733 1529404 Negative_regulation SELL GALNS 9049258 1459434 Negative_regulation SELL GRP 23717139 1614282 Negative_regulation SELL HNRNPF 23632327 1919850 Negative_regulation SELL HNRNPH1 23632327 1919851 Negative_regulation SELL ICAM1 21655059 1635370 Negative_regulation SELL IL12A 23964275 908589 Negative_regulation SELL IL12B 23964275 908590 Negative_regulation SELL IL15 23240056 2727715 Negative_regulation SELL IL15 23819002 2371973 Negative_regulation SELL IL2 23240056 2727716 Negative_regulation SELL ITGAM 23834268 3113778 Negative_regulation SELL LCT PMC4070608 3206072 Negative_regulation SELL MCAT PMC4070608 3206071 Negative_regulation SELL MLST8 23183047 1570076 Negative_regulation SELL MLST8 23183047 1570077 Negative_regulation SELL MOK 23877042 1035737 Negative_regulation SELL MTOR 22937032 2682756 Negative_regulation SELL MTOR 23183047 1570081 Negative_regulation SELL MTOR 23183047 1570082 Negative_regulation SELL P2RX7 15899033 102748 Negative_regulation SELL PI3 22936933 903848 Negative_regulation SELL PIK3CA 22888331 903157 Negative_regulation SELL PIK3R1 22888331 903158 Negative_regulation SELL PTBP1 23632327 1919852 Negative_regulation SELL PTBP2 23632327 1919849 Negative_regulation SELL PTX3 9432978 1602385 Negative_regulation SELL PTX4 9432978 1602384 Negative_regulation SELL RPTOR 23183047 1570079 Negative_regulation SELL RPTOR 23183047 1570080 Negative_regulation SELP HES2 21042567 1078146 Negative_regulation SELP SELL 8909556 1457691 Negative_regulation SELP TNF 12003644 312744 Negative_regulation SELP TNF 21149548 1562253 Negative_regulation SEPP1 SCIN 24963913 2983480 Negative_regulation SEPP1 TNF 20976180 2479175 Negative_regulation SERP1 PLAU 18949070 2208042 Negative_regulation SERPINA1 TNF 20690420 1142922 Negative_regulation SERPINA10 SERPINA5 22675511 2649061 Negative_regulation SERPINA3 LBP 24743550 3066753 Negative_regulation SERPINA5 SERPINA10 22675511 2649065 Negative_regulation SERPINB2 F3 23826213 2811558 Negative_regulation SERPINB2 MUC16 16817968 232105 Negative_regulation SERPINB2 PLAT 16262900 3105748 Negative_regulation SERPINB2 PLAT 21792312 454449 Negative_regulation SERPINB2 PLAU 21792312 454450 Negative_regulation SERPINB2 PLAU 24644264 492659 Negative_regulation SERPINB5 F2R 21378407 2175476 Negative_regulation SERPINC1 CST6 23497084 394577 Negative_regulation SERPINE1 CLU 25148511 3002017 Negative_regulation SERPINE1 EPHB2 17474984 656546 Negative_regulation SERPINE1 PLAT 20140248 2440215 Negative_regulation SERPINE1 PLAT 20532435 512566 Negative_regulation SERPINE1 PLAT 21046291 665336 Negative_regulation SERPINE1 PLAT 21792312 454447 Negative_regulation SERPINE1 PLAT 23204984 684449 Negative_regulation SERPINE1 PLAT 23573292 2778169 Negative_regulation SERPINE1 PLAT 23573292 2778171 Negative_regulation SERPINE1 PLAT 25520834 1630323 Negative_regulation SERPINE1 PLAU 10098758 414091 Negative_regulation SERPINE1 PLAU 10098758 414092 Negative_regulation SERPINE1 PLAU 10390010 414595 Negative_regulation SERPINE1 PLAU 10817495 417090 Negative_regulation SERPINE1 PLAU 11266468 1269202 Negative_regulation SERPINE1 PLAU 11286474 418504 Negative_regulation SERPINE1 PLAU 11437407 419164 Negative_regulation SERPINE1 PLAU 16404434 426889 Negative_regulation SERPINE1 PLAU 21792312 454448 Negative_regulation SERPINE1 PLAU 22276848 335756 Negative_regulation SERPINE1 PLAU 22447922 1492114 Negative_regulation SERPINE1 PLAU 23984088 1151029 Negative_regulation SERPINE1 PLAU 24120085 1667186 Negative_regulation SERPINE1 PLAU 9472634 446857 Negative_regulation SERPINE1 PLAU 9836475 447978 Negative_regulation SERPINE1 PLAU PMC3850830 738730 Negative_regulation SERPINE1 TNF 21494547 2512956 Negative_regulation SERPINE1 TNF 23717597 2798461 Negative_regulation SERPINE1 TNF 24744780 1074066 Negative_regulation SERPINE1 TNF 25110685 196162 Negative_regulation SERPINE1 TNF 25133669 2998729 Negative_regulation SERPINF1 G0S2 24039668 2844511 Negative_regulation SERPINI1 PLAT 18267959 1031634 Negative_regulation SETD1A HES2 23849347 660492 Negative_regulation SETD2 ANGPT1 18835934 707036 Negative_regulation SETD2 EDN2 22874467 834883 Negative_regulation SETD2 EGLN3 19473554 113386 Negative_regulation SETD2 EGLN3 25010988 576856 Negative_regulation SETD2 EMP1 23334331 2151437 Negative_regulation SETD2 EPHB2 21544242 2517396 Negative_regulation SETD2 EPHB2 23869238 2821183 Negative_regulation SETD2 EPHB2 24556680 572159 Negative_regulation SETD2 FOXO1 21696576 260291 Negative_regulation SETD2 FOXO1 21696576 260293 Negative_regulation SETD2 HAS3 25147816 197800 Negative_regulation SETD2 IFI27 25412313 579218 Negative_regulation SETD2 IL1B 22269218 3101534 Negative_regulation SETD2 MAOA 25198178 3005969 Negative_regulation SETD2 PGC 22266669 721058 Negative_regulation SETD2 TNF 25051011 2991139 Negative_regulation SFN CCND1 23927827 269598 Negative_regulation SFTPB TUB 8707828 1453733 Negative_regulation SFXN1 EPHB2 25148033 3001308 Negative_regulation SGK1 FOXO1 19209957 2266062 Negative_regulation SH2B1 TNF 7669565 444124 Negative_regulation SHBG FOLR1 25222748 3007492 Negative_regulation SHBG TNF 19209274 3176890 Negative_regulation SHBG TNF 24058910 184116 Negative_regulation SHBG TNF 24386165 2902941 Negative_regulation SHC1 EPHB2 24349153 2896877 Negative_regulation SHH TMEM100 22046349 2566611 Negative_regulation SHH TMEM156 22046349 2566629 Negative_regulation SHH TMEM211 22046349 2566709 Negative_regulation SHH TMEM213 22046349 2566646 Negative_regulation SHOX2 MSX1 23776616 2805040 Negative_regulation SIGMAR1 TNF 18267009 352102 Negative_regulation SIL1 TNF 21286013 1635346 Negative_regulation SIRT1 ALDH2 24040162 2846024 Negative_regulation SIRT1 ALDH2 24040162 2846026 Negative_regulation SIRT1 ALDH2 24040162 2846029 Negative_regulation SIRT1 EPHB2 22269797 1898901 Negative_regulation SIRT1 FOXO1 23342163 2742617 Negative_regulation SIRT1 TNF 23805409 20464 Negative_regulation SIRT1 TNF 25479074 1135574 Negative_regulation SIRT1 TNF 25501750 3033757 Negative_regulation SIRT3 PGC 20661474 2456740 Negative_regulation SIX1 MAP2K6 22765220 471691 Negative_regulation SKP1 IFI27 19678939 481386 Negative_regulation SKP1 MAP2K6 25401222 2207181 Negative_regulation SKP2 CCND1 17296798 1337091 Negative_regulation SKP2 CCND1 17296798 1337103 Negative_regulation SKP2 CCND1 17407548 1846325 Negative_regulation SKP2 IFI27 19678939 481387 Negative_regulation SKP2 IFI27 23907123 543970 Negative_regulation SKP2 IFI27 24632684 1941045 Negative_regulation SLC12A2 TNF 24916922 1668185 Negative_regulation SLC12A9 CCND1 16457690 459647 Negative_regulation SLC12A9 CCND1 16512916 279072 Negative_regulation SLC12A9 CCND1 20642839 1647226 Negative_regulation SLC12A9 CCND1 22815774 2665998 Negative_regulation SLC12A9 EPHB2 16879721 1163599 Negative_regulation SLC16A3 INS 21779523 2115050 Negative_regulation SLC16A3 NA 23860378 543847 Negative_regulation SLC16A3 SH3BGRL2 22530001 2620869 Negative_regulation SLC1A2 EPHB2 23234294 1665465 Negative_regulation SLC1A2 MAP2K6 23234294 1665472 Negative_regulation SLC1A2 MIP 23234294 1665461 Negative_regulation SLC1A2 TNF 24836816 2971326 Negative_regulation SLC1A2 TNF 24966471 1759849 Negative_regulation SLC1A5 TNF 25574232 845562 Negative_regulation SLC22A3 CCND1 18945340 2001044 Negative_regulation SLC22A3 EPHB2 23544048 2773397 Negative_regulation SLC22A3 FOXA1 24093963 345444 Negative_regulation SLC22A3 FOXA1 24281218 502410 Negative_regulation SLC22A3 ID1 24687377 477587 Negative_regulation SLC22A3 JAG1 22363487 2599527 Negative_regulation SLC22A3 JAG1 22363487 2599570 Negative_regulation SLC22A3 JAG1 22792351 2663417 Negative_regulation SLC22A3 JAG1 23560082 2776375 Negative_regulation SLC22A3 KRT38 23536778 2771609 Negative_regulation SLC22A3 MMP28 22701711 2652186 Negative_regulation SLC22A3 MMP7 22701711 2652201 Negative_regulation SLC22A3 MUC16 21326240 436471 Negative_regulation SLC22A3 MUC16 21326240 436488 Negative_regulation SLC22A3 PIGR 22025622 1651589 Negative_regulation SLC22A3 PIGR 22025622 1651590 Negative_regulation SLC22A3 PIGR 22025622 1651640 Negative_regulation SLC22A3 PIGR 22025622 1651641 Negative_regulation SLC22A3 PIGR 22025622 1651688 Negative_regulation SLC22A3 WIF1 24755295 1873938 Negative_regulation SLC25A16 TNF 21731751 2532411 Negative_regulation SLC25A20 TLR7 19551144 2419910 Negative_regulation SLC27A2 FOXA1 22238690 2587073 Negative_regulation SLC27A5 TNF 11790894 735819 Negative_regulation SLC2A1 TNF 22691241 126144 Negative_regulation SLC2A2 FOXO1 22399922 3158672 Negative_regulation SLC2A2 FOXO1 22399922 3158694 Negative_regulation SLC2A4 PGC 25136584 197215 Negative_regulation SLC2A4 RAB31 19590752 2421188 Negative_regulation SLC2A4 RAB31 20332342 713450 Negative_regulation SLC2A4 TNF 24324517 824424 Negative_regulation SLC2A4 TNF 24349514 2898400 Negative_regulation SLC33A1 EPHB2 23243430 816471 Negative_regulation SLC33A1 EPHB2 23888175 1613847 Negative_regulation SLC40A1 TNF 25255103 3069559 Negative_regulation SLC6A2 ADIPOQ 18762578 1356504 Negative_regulation SLC6A2 ADIPOQ 18845253 686750 Negative_regulation SLC6A2 CRTC1 20947565 2057619 Negative_regulation SLC6A2 CRTC1 20947565 2057623 Negative_regulation SLC6A2 CRTC1 20947565 2057643 Negative_regulation SLC6A2 CRTC1 20947565 2057644 Negative_regulation SLC6A2 ESPL1 18762578 1356505 Negative_regulation SLC6A2 LPA 18827818 431398 Negative_regulation SLC6A2 NET1 24307893 980696 Negative_regulation SLC6A2 NPY6R 18762578 1356506 Negative_regulation SLC6A2 NPY6R 18845253 686751 Negative_regulation SLC6A2 SLC6A4 16022733 143176 Negative_regulation SLC9A1 EPHB2 22904641 490795 Negative_regulation SLC9A2 EGR1 24376510 2900970 Negative_regulation SLC9A2 EGR1 24376510 2900982 Negative_regulation SLC9A3 PDZK1 22848392 2668615 Negative_regulation SLCO2A1 ANXA6 22984583 2689262 Negative_regulation SLCO2A1 INS 24453411 1756649 Negative_regulation SLCO6A1 FAS 20470393 1504192 Negative_regulation SLCO6A1 FAS 20470393 1504194 Negative_regulation SLPI ANGPT1 23507924 179113 Negative_regulation SLPI NES 19696784 785907 Negative_regulation SLPI ZFP57 21173110 1383367 Negative_regulation SMAD1 ANGPT1 24877152 192114 Negative_regulation SMAD1 EPHB2 17325210 1337645 Negative_regulation SMAD1 ID1 20565867 1856098 Negative_regulation SMAD1 ID1 20565867 1856099 Negative_regulation SMAD1 ID1 20565867 1856168 Negative_regulation SMAD1 ID1 20565867 1856169 Negative_regulation SMAD1 PIGR 22025622 1651642 Negative_regulation SMAD2 ANGPT1 24459518 746250 Negative_regulation SMAD2 ANGPT1 24877152 192115 Negative_regulation SMAD2 CTGF 23383241 2749613 Negative_regulation SMAD2 EPHB2 24533426 1636605 Negative_regulation SMAD2 ID1 20565867 1856102 Negative_regulation SMAD2 ID1 20565867 1856103 Negative_regulation SMAD2 ID1 20565867 1856171 Negative_regulation SMAD2 ID1 20565867 1856172 Negative_regulation SMAD2 PIGR 22025622 1651643 Negative_regulation SMAD2 PIGR 22025622 1651644 Negative_regulation SMAD2 TNF 19087346 3109084 Negative_regulation SMAD3 ANGPT1 24459518 746252 Negative_regulation SMAD3 ANGPT1 24877152 192116 Negative_regulation SMAD3 CLU 25148511 3002016 Negative_regulation SMAD3 EPHB2 17474984 656568 Negative_regulation SMAD3 EPHB2 24533426 1636606 Negative_regulation SMAD3 ID1 20565867 1856106 Negative_regulation SMAD3 ID1 20565867 1856107 Negative_regulation SMAD3 ID1 20565867 1856174 Negative_regulation SMAD3 ID1 20565867 1856175 Negative_regulation SMAD3 PIGR 22025622 1651645 Negative_regulation SMAD3 PIGR 22025622 1651646 Negative_regulation SMAD3 TNF 22313861 3160939 Negative_regulation SMAD4 ANGPT1 24877152 192117 Negative_regulation SMAD4 EPHB2 20712893 1858041 Negative_regulation SMAD4 EPHB2 20712893 1858098 Negative_regulation SMAD4 ID1 20565867 1856110 Negative_regulation SMAD4 ID1 20565867 1856111 Negative_regulation SMAD4 ID1 20565867 1856177 Negative_regulation SMAD4 ID1 20565867 1856178 Negative_regulation SMAD4 MAP2K6 20712893 1858047 Negative_regulation SMAD4 MAP2K6 20712893 1858104 Negative_regulation SMAD4 PIGR 22025622 1651647 Negative_regulation SMAD5 ANGPT1 24877152 192118 Negative_regulation SMAD5 ID1 20565867 1856114 Negative_regulation SMAD5 ID1 20565867 1856115 Negative_regulation SMAD5 ID1 20565867 1856180 Negative_regulation SMAD5 ID1 20565867 1856181 Negative_regulation SMAD5 PIGR 22025622 1651648 Negative_regulation SMAD6 ANGPT1 24877152 192119 Negative_regulation SMAD6 ID1 20565867 1856118 Negative_regulation SMAD6 ID1 20565867 1856119 Negative_regulation SMAD6 ID1 20565867 1856183 Negative_regulation SMAD6 ID1 20565867 1856184 Negative_regulation SMAD6 MSX1 25615642 3038601 Negative_regulation SMAD6 PIGR 22025622 1651649 Negative_regulation SMAD7 ANGPT1 24877152 192120 Negative_regulation SMAD7 EPHB2 24533426 1636623 Negative_regulation SMAD7 ID1 20565867 1856122 Negative_regulation SMAD7 ID1 20565867 1856123 Negative_regulation SMAD7 ID1 20565867 1856186 Negative_regulation SMAD7 ID1 20565867 1856187 Negative_regulation SMAD7 PIGR 22025622 1651650 Negative_regulation SMAD9 ANGPT1 24877152 192121 Negative_regulation SMAD9 ID1 20565867 1856126 Negative_regulation SMAD9 ID1 20565867 1856127 Negative_regulation SMAD9 ID1 20565867 1856189 Negative_regulation SMAD9 ID1 20565867 1856190 Negative_regulation SMAD9 PIGR 22025622 1651651 Negative_regulation SMARCA4 UCA1 24993775 2171793 Negative_regulation SMARCA4 UCA1 24993775 2171805 Negative_regulation SMC2 ANGPT1 18835934 707043 Negative_regulation SMC2 FAS 21211039 1243680 Negative_regulation SMC3 ANGPT1 18835934 707047 Negative_regulation SMC3 FAS 21211039 1243688 Negative_regulation SMC4 ANGPT1 18835934 707044 Negative_regulation SMC4 FAS 21211039 1243682 Negative_regulation SMC5 ANGPT1 18835934 707045 Negative_regulation SMC5 FAS 21211039 1243684 Negative_regulation SMC6 ANGPT1 18835934 707046 Negative_regulation SMC6 FAS 21211039 1243686 Negative_regulation SMCP TNFSF10 21092273 1860265 Negative_regulation SMN1 CTGF 24853416 576005 Negative_regulation SMN1 EPHB2 21224849 768978 Negative_regulation SMN1 EPHB2 21224849 769084 Negative_regulation SMN1 EPHB2 24282625 2887138 Negative_regulation SMN1 HBEGF 22330337 1717961 Negative_regulation SMN1 PLAU 23018346 1735668 Negative_regulation SMN1 SMN2 18791638 2396432 Negative_regulation SMN1 SMN2 18941511 2398932 Negative_regulation SMN1 SMN2 18957104 385069 Negative_regulation SMN1 SMN2 21708901 739056 Negative_regulation SMN1 SMN2 21936964 3169124 Negative_regulation SMN1 SMN2 22701806 2002680 Negative_regulation SMN1 SMN2 23284781 2730946 Negative_regulation SMN1 SMN2 24405637 2221756 Negative_regulation SMN1 SMN2 25338097 3018542 Negative_regulation SMN1 TNF 20064200 118112 Negative_regulation SMN2 APITD1 17548509 1340856 Negative_regulation SMN2 ARG1 15743974 2015739 Negative_regulation SMN2 ARG2 15743974 2015740 Negative_regulation SMN2 BCL10 25075304 848821 Negative_regulation SMN2 DDX20 21339974 1090453 Negative_regulation SMN2 DDX20 24210254 2008283 Negative_regulation SMN2 GEMIN2 17640370 280471 Negative_regulation SMN2 GEMIN2 19915660 2430944 Negative_regulation SMN2 GEMIN2 21339974 1090447 Negative_regulation SMN2 GEMIN2 24210254 2008277 Negative_regulation SMN2 GEMIN4 21339974 1090449 Negative_regulation SMN2 GEMIN4 24210254 2008279 Negative_regulation SMN2 GEMIN5 21339974 1090450 Negative_regulation SMN2 GEMIN5 24210254 2008280 Negative_regulation SMN2 GEMIN6 21339974 1090451 Negative_regulation SMN2 GEMIN6 24210254 2008281 Negative_regulation SMN2 GEMIN7 21339974 1090452 Negative_regulation SMN2 GEMIN7 24210254 2008282 Negative_regulation SMN2 HDAC1 18971205 1031871 Negative_regulation SMN2 HDAC1 18971205 1031872 Negative_regulation SMN2 HDAC1 18971205 1031873 Negative_regulation SMN2 HDAC1 18971205 1031882 Negative_regulation SMN2 HDAC1 18971205 1031886 Negative_regulation SMN2 HDAC1 22291761 95023 Negative_regulation SMN2 HDAC1 25075304 848866 Negative_regulation SMN2 HDAC1 25642438 88116 Negative_regulation SMN2 HDAC10 18971205 1031869 Negative_regulation SMN2 HDAC11 18971205 1031870 Negative_regulation SMN2 HDAC2 18971205 1031874 Negative_regulation SMN2 HDAC2 18971205 1031875 Negative_regulation SMN2 HDAC2 18971205 1031876 Negative_regulation SMN2 HDAC2 18971205 1031883 Negative_regulation SMN2 HDAC2 18971205 1031887 Negative_regulation SMN2 HDAC2 22291761 95024 Negative_regulation SMN2 HDAC2 25075304 848867 Negative_regulation SMN2 HDAC2 25642438 88117 Negative_regulation SMN2 HDAC3 18971205 1031877 Negative_regulation SMN2 HDAC4 18971205 1031864 Negative_regulation SMN2 HDAC5 18971205 1031868 Negative_regulation SMN2 HDAC6 18971205 1031865 Negative_regulation SMN2 HDAC7 18971205 1031867 Negative_regulation SMN2 HDAC8 18971205 1031863 Negative_regulation SMN2 HDAC9 18971205 1031866 Negative_regulation SMN2 MALT1 25075304 848820 Negative_regulation SMN2 MECP2 18971205 1031890 Negative_regulation SMN2 PIEZO1 23615451 1813926 Negative_regulation SMN2 RBBP4 18971205 1031878 Negative_regulation SMN2 RBBP4 18971205 1031879 Negative_regulation SMN2 RBBP4 18971205 1031884 Negative_regulation SMN2 RBBP4 18971205 1031888 Negative_regulation SMN2 RBBP4 22291761 95025 Negative_regulation SMN2 RBBP4 25075304 848868 Negative_regulation SMN2 RBBP4 25642438 88118 Negative_regulation SMN2 RBBP7 18971205 1031880 Negative_regulation SMN2 RBBP7 18971205 1031881 Negative_regulation SMN2 RBBP7 18971205 1031885 Negative_regulation SMN2 RBBP7 18971205 1031889 Negative_regulation SMN2 RBBP7 22291761 95026 Negative_regulation SMN2 RBBP7 25075304 848869 Negative_regulation SMN2 RBBP7 25642438 88119 Negative_regulation SMN2 SMN2 21339974 1090448 Negative_regulation SMN2 SMN2 24210254 2008278 Negative_regulation SMN2 TAB2 25075304 848819 Negative_regulation SMN2 TRAF6 25075304 848817 Negative_regulation SMN2 UBE2V1 25075304 848818 Negative_regulation SMO TMEM100 23935925 2828288 Negative_regulation SMO TMEM156 23935925 2828306 Negative_regulation SMO TMEM211 23935925 2828386 Negative_regulation SMO TMEM213 23935925 2828323 Negative_regulation SMURF1 EPHB2 22396737 2608336 Negative_regulation SMURF1 TNF 22396737 2608335 Negative_regulation SMURF2 EPHB2 22396737 2608338 Negative_regulation SMURF2 TNF 22396737 2608337 Negative_regulation SMURF2 TNF 23969857 564896 Negative_regulation SNAI1 HBEGF 22592159 1630913 Negative_regulation SNAI1 TNF 23437179 2755923 Negative_regulation SNAI2 NEDD9 21829474 2541152 Negative_regulation SNAI2 PECAM1 21324930 738955 Negative_regulation SNAP23 SYT8 PMC2589129 3230383 Negative_regulation SNCA SNCAIP 18366718 359884 Negative_regulation SNCA SNCAIP 24829096 2970057 Negative_regulation SNCAIP SFTPA2 9214378 1461163 Negative_regulation SNCAIP SFTPA2 9214378 1461165 Negative_regulation SNORD87 IFI27 22098949 624198 Negative_regulation SNRPA SMN2 21339974 1090455 Negative_regulation SNRPA SMN2 24210254 2008285 Negative_regulation SNRPB SMN2 21339974 1090462 Negative_regulation SNRPB SMN2 24210254 2008292 Negative_regulation SOAT1 CCND1 19888451 2430282 Negative_regulation SOAT1 HES2 22530164 2232448 Negative_regulation SOAT1 TLR7 23505488 2766197 Negative_regulation SOCS1 ITGAL 22911848 2677082 Negative_regulation SOCS1 S100A7 15217486 458452 Negative_regulation SOCS1 S100A7 20955608 585861 Negative_regulation SOCS1 TLR7 20862390 979644 Negative_regulation SOCS1 TLR7 22566904 899826 Negative_regulation SOCS1 TLR7 24069550 1706659 Negative_regulation SOCS3 EPHB2 24260222 2882857 Negative_regulation SOCS3 IL1B 18989459 3042186 Negative_regulation SOCS3 TLR7 24069550 1706670 Negative_regulation SOD1 PGC 22742579 292147 Negative_regulation SOD1 TNF 12745546 1738366 Negative_regulation SOD1 TNF 24302863 3155495 Negative_regulation SOD1 TNF 24381587 23148 Negative_regulation SOD1 TNF 25120637 844972 Negative_regulation SOD1 TNF 7523104 796015 Negative_regulation SOD1 ZFP57 25071223 1502808 Negative_regulation SOD2 PGC 20383327 2445868 Negative_regulation SOD2 TNF 12745546 1738378 Negative_regulation SOD2 TNF 23078757 660367 Negative_regulation SOD2 TNF 24381587 23150 Negative_regulation SOD2 TNF 25120637 844973 Negative_regulation SOD2 TNF 7523104 796016 Negative_regulation SOD2 ZFP57 25071223 1502826 Negative_regulation SOD3 TNF 12745546 1738390 Negative_regulation SOD3 TNF 23187006 219812 Negative_regulation SOD3 TNF 24302863 3155496 Negative_regulation SOD3 TNF 24381587 23152 Negative_regulation SOD3 TNF 25120637 844974 Negative_regulation SOD3 TNF 7523104 796017 Negative_regulation SOD3 ZFP57 25071223 1502844 Negative_regulation SORL1 BDNF 23977241 2839400 Negative_regulation SORL1 GGA1 22621900 1803321 Negative_regulation SOS1 EPHB2 23365639 2745178 Negative_regulation SOS2 EPHB2 23365639 2745181 Negative_regulation SOST EPHB2 21723865 850878 Negative_regulation SOST EPHB2 23362266 1206190 Negative_regulation SOST EPHB2 23362266 1206191 Negative_regulation SOST EPHB2 23362266 1206211 Negative_regulation SOST EPHB2 23362266 1206212 Negative_regulation SOST MAP2K6 23362266 1206197 Negative_regulation SOX17 MAP2K6 22276221 2590652 Negative_regulation SOX2 ID1 24457967 571645 Negative_regulation SOX2 IFI27 23217425 615780 Negative_regulation SOX2 IFI27 23217425 615794 Negative_regulation SOX2 IFI27 23217425 615797 Negative_regulation SOX2 IFI27 23505216 1035351 Negative_regulation SOX2 MAP2K6 25340657 2366617 Negative_regulation SOX2 MAP2K6 25340657 2366709 Negative_regulation SOX4 EPHB2 23251334 2727753 Negative_regulation SOX4 EPHB2 23251334 2727787 Negative_regulation SOX4 MAP2K6 23251334 2727759 Negative_regulation SOX4 MAP2K6 23251334 2727795 Negative_regulation SOX6 EPHB2 25068118 3167129 Negative_regulation SOX7 CCND1 24816720 2963008 Negative_regulation SOX9 CTGF 19152120 1478436 Negative_regulation SOX9 EPHB2 20800688 2222146 Negative_regulation SOX9 MAP2K6 12105181 1284448 Negative_regulation SOX9 MAP2K6 20800688 2222152 Negative_regulation SOX9 TNF 18182117 109756 Negative_regulation SOX9 TNF 18182117 109786 Negative_regulation SOX9 TNF 18182117 109794 Negative_regulation SOX9 TNF 18182117 109797 Negative_regulation SP1 EPHB2 18852899 2397562 Negative_regulation SP1 FOXA1 23166858 3131695 Negative_regulation SP1 FOXO1 22477519 1238982 Negative_regulation SP1 IFI27 25099028 1702427 Negative_regulation SP100 CD14 20236452 659484 Negative_regulation SP8 NR2F1 20862356 2291760 Negative_regulation SPAG11B PTGER2 22654101 1203469 Negative_regulation SPAG8 EPHB2 22294469 135249 Negative_regulation SPC24 TUB 21573187 2522916 Negative_regulation SPC25 TUB 21573187 2522915 Negative_regulation SPHK1 ABCC1 21629665 2525377 Negative_regulation SPHK1 CERS1 22654794 875965 Negative_regulation SPHK1 CERS2 22654794 875964 Negative_regulation SPHK1 CERS3 22654794 875968 Negative_regulation SPHK1 CERS4 22654794 875966 Negative_regulation SPHK1 CERS5 22654794 875967 Negative_regulation SPHK1 CERS6 22654794 875969 Negative_regulation SPHK1 DHPS 15927078 3105009 Negative_regulation SPHK1 DHPS 20498849 2451158 Negative_regulation SPHK1 EGFR 25245676 2201805 Negative_regulation SPHK1 EPHB2 24917786 931934 Negative_regulation SPHK1 ETS1 21936950 1697755 Negative_regulation SPHK1 GPER1 16636149 1329248 Negative_regulation SPHK1 HBD 20634980 2455665 Negative_regulation SPHK1 HPR 24009836 203695 Negative_regulation SPHK1 HSPB1 24025642 1709534 Negative_regulation SPHK1 INS 24349009 2896555 Negative_regulation SPHK1 LPA 21936950 1697759 Negative_regulation SPHK1 MAP2K1 24917786 931935 Negative_regulation SPHK1 MAP2K2 24917786 931936 Negative_regulation SPHK1 MAP2K3 24917786 931937 Negative_regulation SPHK1 MAP2K4 24917786 931938 Negative_regulation SPHK1 MAP2K5 24917786 931939 Negative_regulation SPHK1 MAP2K6 24917786 931940 Negative_regulation SPHK1 MAP2K7 24917786 931941 Negative_regulation SPHK1 MAPK3 21936950 1697756 Negative_regulation SPHK1 MAPKAPK2 24917786 931942 Negative_regulation SPHK1 MBTPS1 16847102 1331288 Negative_regulation SPHK1 MBTPS1 24464131 1959651 Negative_regulation SPHK1 MBTPS1 24586752 2926289 Negative_regulation SPHK1 MBTPS1 25050888 2991101 Negative_regulation SPHK1 MBTPS1 PMC4273882 661379 Negative_regulation SPHK1 MKNK1 24917786 931943 Negative_regulation SPHK1 NPC1 25417698 1947371 Negative_regulation SPHK1 PAPSS1 23770847 2152604 Negative_regulation SPHK1 PAPSS1 24286034 207196 Negative_regulation SPHK1 PIK3CA 20634980 2455666 Negative_regulation SPHK1 PIK3CA 20634980 2455713 Negative_regulation SPHK1 PIK3CA 20634980 2455790 Negative_regulation SPHK1 PIK3R1 20634980 2455667 Negative_regulation SPHK1 PIK3R1 20634980 2455714 Negative_regulation SPHK1 PIK3R1 20634980 2455791 Negative_regulation SPHK1 S1PR3 21887342 2549366 Negative_regulation SPHK1 SGPP1 25383881 3024529 Negative_regulation SPHK1 SKI 24572701 652048 Negative_regulation SPHK1 SKIV2L 22061047 261709 Negative_regulation SPHK1 SKIV2L 22788716 3161138 Negative_regulation SPHK1 SKIV2L 24367685 2900562 Negative_regulation SPHK1 SKIV2L 24376889 2902702 Negative_regulation SPHK1 SKIV2L 24376889 2902704 Negative_regulation SPHK1 SKIV2L 24376889 2902705 Negative_regulation SPHK1 SKIV2L 25245676 2201747 Negative_regulation SPHK1 SPHK1 16636149 1329275 Negative_regulation SPHK1 SPHK1 24929359 1930897 Negative_regulation SPHK1 SPHK2 16636149 1329276 Negative_regulation SPHK1 SPHK2 24069553 1706807 Negative_regulation SPHK1 SPHK2 24929359 1930898 Negative_regulation SPHK1 SPHK2 25383881 3024530 Negative_regulation SPHK1 SPP1 10545499 1251547 Negative_regulation SPHK1 SPP2 10545499 1251548 Negative_regulation SPHK1 TP53 23028939 2693650 Negative_regulation SPHK1 TTC37 22788716 3161139 Negative_regulation SPHK1 TTC37 24367685 2900563 Negative_regulation SPHK1 WDR61 22788716 3161140 Negative_regulation SPHK1 WDR61 24367685 2900564 Negative_regulation SPHK2 EPHB2 24917786 931944 Negative_regulation SPHK2 MAP2K6 24917786 931950 Negative_regulation SPHK2 SPHK1 16636149 1329277 Negative_regulation SPN TNF 8391001 1448090 Negative_regulation SPP1 EPHB2 21406114 286528 Negative_regulation SPP1 SPHK1 10545499 1251512 Negative_regulation SPP1 SPHK1 10545499 1251549 Negative_regulation SPP1 SPHK1 10545499 1251563 Negative_regulation SPP1 TNF 24490170 186727 Negative_regulation SPP2 SPHK1 10545499 1251514 Negative_regulation SPP2 SPHK1 10545499 1251551 Negative_regulation SPP2 SPHK1 10545499 1251565 Negative_regulation SPRED2 MAP2K6 24970815 2194241 Negative_regulation SPRR1B SDCBP 25593999 2173507 Negative_regulation SPRR1B SDCBP 25593999 2173513 Negative_regulation SPRR3 JUN 24796531 2960566 Negative_regulation SPRY1 EPHB2 24932220 1679399 Negative_regulation SPRY4 MAP2K6 24970815 2194297 Negative_regulation SRC ANGPT1 22187650 1145417 Negative_regulation SRC CTGF 23175185 548163 Negative_regulation SRC CTGF 23175185 548177 Negative_regulation SRC CTGF 23175185 548186 Negative_regulation SRC EPHB2 24839453 825906 Negative_regulation SRC HBEGF 22446737 1928262 Negative_regulation SRC MAP2K6 22284833 805785 Negative_regulation SRC NEDD9 24058594 2848157 Negative_regulation SRC NEDD9 24058594 2848159 Negative_regulation SRC PLAU 23843896 3177317 Negative_regulation SRC TNF 24502696 1233362 Negative_regulation SREBF1 EPHB2 23153363 1725115 Negative_regulation SREBF1 FAS 24070020 1869750 Negative_regulation SREBF1 FBXO32 23226416 2724651 Negative_regulation SREBF1 FOXO1 25045276 645399 Negative_regulation SREBF1 TNF 21988829 1723918 Negative_regulation SREBF1 TNF 23800945 1606783 Negative_regulation SRF EPHB2 24945272 2372802 Negative_regulation SRF FOXO1 23554919 2773861 Negative_regulation SRGN INS 18200811 3208554 Negative_regulation SRP14 SMN2 23221635 2082644 Negative_regulation SRP19 SMN2 23221635 2082649 Negative_regulation SRP54 SMN2 23221635 2082654 Negative_regulation SRP68 SMN2 23221635 2082659 Negative_regulation SRP72 SMN2 23221635 2082664 Negative_regulation SRP9 SMN2 23221635 2082669 Negative_regulation SST EPHB2 21589940 2523401 Negative_regulation ST3 GNE 20383336 2445904 Negative_regulation STAT1 ARSA 24039842 2844937 Negative_regulation STAT1 ARSA 24039842 2844952 Negative_regulation STAT1 CCND1 22423663 1865264 Negative_regulation STAT1 EPHB2 19895680 1006864 Negative_regulation STAT1 EPHB2 20861313 1783193 Negative_regulation STAT1 LIPG 22253910 2588336 Negative_regulation STAT1 MAP2K6 20861313 1783188 Negative_regulation STAT1 STAT4 25400632 915164 Negative_regulation STAT1 TNF 25629010 865449 Negative_regulation STAT2 MAP2K6 22970192 2687673 Negative_regulation STAT3 ARSA 23306703 835019 Negative_regulation STAT3 CAPN8 25352693 1713474 Negative_regulation STAT3 CCND1 19554087 2420026 Negative_regulation STAT3 CCND1 22423663 1865266 Negative_regulation STAT3 CCND1 24743777 504255 Negative_regulation STAT3 CEACAM6 22905257 2675848 Negative_regulation STAT3 EPHB2 11034602 1517565 Negative_regulation STAT3 EPHB2 21347362 2503672 Negative_regulation STAT3 EPHB2 21871133 1863066 Negative_regulation STAT3 EPHB2 21871133 1863076 Negative_regulation STAT3 EPHB2 23781121 1753377 Negative_regulation STAT3 EPHB2 24288470 3155215 Negative_regulation STAT3 EPHB2 24312439 2889328 Negative_regulation STAT3 EPHB2 25383546 3024170 Negative_regulation STAT3 EPHB2 25383546 3024172 Negative_regulation STAT3 FOXO1 21765927 2536261 Negative_regulation STAT3 IFI27 23549262 1104718 Negative_regulation STAT3 MAP2K6 11034602 1517571 Negative_regulation STAT3 MAP2K6 21347362 2503678 Negative_regulation STAT3 MAP2K6 22319590 2595556 Negative_regulation STAT3 MAP2K6 24288470 3155225 Negative_regulation STAT3 MAP2K6 24312439 2889335 Negative_regulation STAT3 STAT4 24058755 1704877 Negative_regulation STAT3 STAT4 24069552 1706775 Negative_regulation STAT3 STAT4 25045206 1760108 Negative_regulation STAT3 TNF 22351606 778109 Negative_regulation STAT4 CD1D 20593019 2454362 Negative_regulation STAT4 DOK1 22514638 2619618 Negative_regulation STAT4 GATA3 16520391 1539665 Negative_regulation STAT4 GATA3 19808254 1556469 Negative_regulation STAT4 GATA3 21772714 1623925 Negative_regulation STAT4 GGT2 22729903 1832221 Negative_regulation STAT4 IFNR PMC4033917 2245634 Negative_regulation STAT4 IL12A 23386861 883431 Negative_regulation STAT4 IL12B 23386861 883432 Negative_regulation STAT4 IL12RB1 24391825 2904650 Negative_regulation STAT4 IL12RB2 24391825 2904651 Negative_regulation STAT4 IL21 12370258 1525008 Negative_regulation STAT4 IL21 12370258 1525009 Negative_regulation STAT4 IL4 16520391 1539666 Negative_regulation STAT4 PIAS4 24199193 184827 Negative_regulation STAT4 PIAS4 24252238 178784 Negative_regulation STAT4 PPP2CA 17875674 1547011 Negative_regulation STAT4 PPP2R1A 17875674 1547012 Negative_regulation STAT4 PPP2R2B 17875674 1547013 Negative_regulation STAT4 SOCS3 15535835 101844 Negative_regulation STAT4 SOCS3 22132325 1686778 Negative_regulation STAT4 SOCS3 22566904 899795 Negative_regulation STAT4 STAT1 25400632 915165 Negative_regulation STAT4 STAT4 22729903 1832220 Negative_regulation STAT4 STMN1 25007915 1943047 Negative_regulation STAT4 TYK2 22723949 2655356 Negative_regulation STAT5A CAPN8 25352693 1713488 Negative_regulation STAT5A EPHB2 12888825 423003 Negative_regulation STAT5A EPHB2 22649371 874917 Negative_regulation STAT5A MAP2K6 22649371 874825 Negative_regulation STAT5A STAT4 25045206 1760109 Negative_regulation STAT6 CAPN8 24707444 1490738 Negative_regulation STK10 IFI27 25294944 704827 Negative_regulation STK11 DAPK1 24710474 618124 Negative_regulation STK11 EPHB2 24710474 618127 Negative_regulation STK11 IFI27 25294944 704829 Negative_regulation STK16 IFI27 25294944 704831 Negative_regulation STK19 IFI27 25294944 704833 Negative_regulation STK24 IFI27 25294944 704835 Negative_regulation STK25 IFI27 25294944 704837 Negative_regulation STK3 IFI27 25294944 704839 Negative_regulation STK3 MAP2K6 22035226 528033 Negative_regulation STK31 IFI27 25294944 704841 Negative_regulation STK33 IFI27 25294944 704845 Negative_regulation STK35 IFI27 25294944 704847 Negative_regulation STK36 IFI27 25294944 704849 Negative_regulation STK38 IFI27 25294944 704853 Negative_regulation STK39 BRAF 22792460 622951 Negative_regulation STK39 GRAP2 17988378 392816 Negative_regulation STK39 IFI27 25294944 704851 Negative_regulation STK39 INS 23610527 731401 Negative_regulation STK39 MAPK1 17988378 392817 Negative_regulation STK39 MAPK10 17988378 392818 Negative_regulation STK39 MAPK11 17988378 392819 Negative_regulation STK39 MAPK12 17988378 392820 Negative_regulation STK39 MAPK13 17988378 392821 Negative_regulation STK39 MAPK14 17988378 392822 Negative_regulation STK39 MAPK15 17988378 392815 Negative_regulation STK39 MAPK3 17988378 392823 Negative_regulation STK39 MAPK4 17988378 392824 Negative_regulation STK39 MAPK6 17988378 392825 Negative_regulation STK39 MAPK7 17988378 392826 Negative_regulation STK39 MAPK8 17988378 392827 Negative_regulation STK39 MAPK9 17988378 392828 Negative_regulation STK39 MTOR 20835268 11861 Negative_regulation STK39 MTOR 23788913 657405 Negative_regulation STK39 PCNA 25294944 704852 Negative_regulation STK39 PIK3CA 19365570 1909073 Negative_regulation STK39 PIK3R1 19365570 1909074 Negative_regulation STK39 PTEN 23610527 731402 Negative_regulation STK39 SLC22A3 19604397 253811 Negative_regulation STK39 TSC1 23580196 740440 Negative_regulation STK4 IFI27 25294944 704843 Negative_regulation STK4 ITGAL 24040101 2845672 Negative_regulation STK40 IFI27 25294944 704855 Negative_regulation STRAP SMN2 21339974 1090504 Negative_regulation STRAP SMN2 24210254 2008334 Negative_regulation STS PLAGL1 24260468 2884376 Negative_regulation STX6 SYT8 PMC2589129 3230400 Negative_regulation SULT1A1 KLF9 18783612 3096696 Negative_regulation SUN2 LINC00284 21627841 286856 Negative_regulation SUN2 LINC00341 21627841 286816 Negative_regulation SYK EPHB2 24876949 141000 Negative_regulation SYK EPHB2 24876949 141001 Negative_regulation SYK RCAN1 19124655 1553298 Negative_regulation SYNM KIF11 24327603 2186123 Negative_regulation SYNM POU6F1 24667541 2938774 Negative_regulation SYNM TAPBP 25566128 972836 Negative_regulation SYNPO TNF 23840712 2816203 Negative_regulation SYNPO TNF 23840712 2816204 Negative_regulation SYNPO TNF 23840712 2816208 Negative_regulation SYNPO TNF 23840712 2816209 Negative_regulation SYNPO TNF 23840712 2816210 Negative_regulation SYP EPHB2 21076532 1674788 Negative_regulation SYP EPHB2 22144984 832237 Negative_regulation SYP NNMT 23764850 562411 Negative_regulation SYT1 ANKRD1 24434510 570878 Negative_regulation SYT1 ARSA 20137092 1722978 Negative_regulation SYT1 CD14 23704945 2797054 Negative_regulation SYT1 EPHB2 22286758 2146182 Negative_regulation SYT1 FAS 21364648 549822 Negative_regulation SYT1 IL1B 21539730 1626352 Negative_regulation SYT1 TCN1 23936501 2831120 Negative_regulation SYT1 TNF 11481030 312645 Negative_regulation SYT1 TNF 21539730 1626351 Negative_regulation SYT1 TNF 21572963 2520287 Negative_regulation SYT1 TNF 23637609 3060927 Negative_regulation SYT1 TNF 23861891 2820556 Negative_regulation SYT1 TNF 24283517 130089 Negative_regulation SYT1 TNF 24283517 130123 Negative_regulation SYT1 TNF 24371075 1704453 Negative_regulation SYT1 TNF 24614867 2933161 Negative_regulation SYT1 TNF 24614867 2933163 Negative_regulation SYT8 APP 24086147 2351130 Negative_regulation SYT8 APP 24086147 2351254 Negative_regulation SYT8 PPP3CA 24086147 2351131 Negative_regulation SYT8 PPP3CA 24086147 2351132 Negative_regulation SYT8 PPP3CB 24086147 2351133 Negative_regulation SYT8 PPP3CC 24086147 2351134 Negative_regulation SYT8 PPP3R1 24086147 2351135 Negative_regulation SYT8 WNT7B 16818724 1330979 Negative_regulation TAB1 NEDD9 24980047 1576869 Negative_regulation TAB2 EPHB2 21048967 2480262 Negative_regulation TAB2 EPHB2 22396737 2608340 Negative_regulation TAB2 TNF 22396737 2608339 Negative_regulation TAB3 IL1B 24936144 1085256 Negative_regulation TAF1 HES2 23849347 660457 Negative_regulation TAF6 HES2 23849347 660464 Negative_regulation TAF9 HES2 23849347 660471 Negative_regulation TANK TNF 16115325 1036144 Negative_regulation TANK TNF 23470535 560774 Negative_regulation TANK TNFSF10 18606850 1353453 Negative_regulation TAS2R38 CTGF 23750089 163597 Negative_regulation TCEA1 CAPN8 19183810 2405137 Negative_regulation TCEA1 ELOVL4 21139992 1912417 Negative_regulation TCEA1 FHL1 18611274 281573 Negative_regulation TCEA1 FOXA1 22238690 2587084 Negative_regulation TCEA1 HBEGF 22446737 1928265 Negative_regulation TCEA1 ITGAL 22711877 1568396 Negative_regulation TCEA1 MAP2K6 24649261 1884434 Negative_regulation TCEA1 SRGN 20032306 1772589 Negative_regulation TCEA1 TMOD1 12975349 1297041 Negative_regulation TCEA1 TMOD1 12975349 1297083 Negative_regulation TCEA1 TMOD1 20737540 694954 Negative_regulation TCEA1 TMOD1 24866031 989399 Negative_regulation TCEA1 TMOD1 7730404 1439774 Negative_regulation TCEA1 TMOD1 7798317 1441653 Negative_regulation TCEA1 TMOD1 7798317 1441677 Negative_regulation TCEA1 TMOD1 7798317 1441702 Negative_regulation TCEA1 TMOD1 7798317 1441710 Negative_regulation TCEA1 TMOD1 7798317 1441766 Negative_regulation TCF12 ARSA 20858269 1859043 Negative_regulation TCF12 AXIN2 22567304 86246 Negative_regulation TCF12 CCND1 22570653 1673717 Negative_regulation TCF12 CCND1 22751438 541593 Negative_regulation TCF12 CCND1 25143352 785251 Negative_regulation TCF12 CLU 25148511 3002002 Negative_regulation TCF12 EPHB2 21253577 3050480 Negative_regulation TCF12 EPHB2 22312244 1094642 Negative_regulation TCF12 FAS 19876397 2429855 Negative_regulation TCF12 FOXA1 18003659 2031539 Negative_regulation TCF12 FOXO1 21902831 3160697 Negative_regulation TCF12 FOXO1 21902831 3160765 Negative_regulation TCF12 FOXO1 22110478 832165 Negative_regulation TCF12 FOXO1 23737653 1753205 Negative_regulation TCF12 ID1 24369462 1073856 Negative_regulation TCF12 ID1 25115386 2197601 Negative_regulation TCF12 OSR1 24931004 1681233 Negative_regulation TCF12 OSR1 24931004 1681301 Negative_regulation TCF12 PCDH19 19956686 2311625 Negative_regulation TCF12 PCDH8 19956686 2311630 Negative_regulation TCF12 PLAU 23984088 1150922 Negative_regulation TCF12 TNF 21915344 2553378 Negative_regulation TCF12 TNF 21915344 2553434 Negative_regulation TCF12 TNF 22419908 951351 Negative_regulation TCF12 WIF1 20573255 1856498 Negative_regulation TCF12 WIF1 20573255 1856545 Negative_regulation TCF15 ARSA 20858269 1859044 Negative_regulation TCF15 AXIN2 22567304 86248 Negative_regulation TCF15 CCND1 22570653 1673719 Negative_regulation TCF15 CCND1 22751438 541594 Negative_regulation TCF15 CCND1 25143352 785252 Negative_regulation TCF15 CLU 25148511 3002003 Negative_regulation TCF15 EPHB2 21253577 3050483 Negative_regulation TCF15 EPHB2 22312244 1094644 Negative_regulation TCF15 FAS 19876397 2429861 Negative_regulation TCF15 FOXA1 18003659 2031541 Negative_regulation TCF15 FOXO1 21902831 3160698 Negative_regulation TCF15 FOXO1 21902831 3160766 Negative_regulation TCF15 FOXO1 22110478 832167 Negative_regulation TCF15 FOXO1 23737653 1753206 Negative_regulation TCF15 ID1 24369462 1073857 Negative_regulation TCF15 ID1 25115386 2197602 Negative_regulation TCF15 OSR1 24931004 1681235 Negative_regulation TCF15 OSR1 24931004 1681302 Negative_regulation TCF15 PCDH19 19956686 2311636 Negative_regulation TCF15 PCDH8 19956686 2311641 Negative_regulation TCF15 PLAU 23984088 1150924 Negative_regulation TCF15 TNF 21915344 2553379 Negative_regulation TCF15 TNF 21915344 2553435 Negative_regulation TCF15 TNF 22419908 951352 Negative_regulation TCF15 WIF1 20573255 1856499 Negative_regulation TCF15 WIF1 20573255 1856546 Negative_regulation TCF19 ARSA 20858269 1859045 Negative_regulation TCF19 AXIN2 22567304 86250 Negative_regulation TCF19 CCND1 22570653 1673721 Negative_regulation TCF19 CCND1 22751438 541595 Negative_regulation TCF19 CCND1 25143352 785253 Negative_regulation TCF19 CLU 25148511 3002004 Negative_regulation TCF19 EPHB2 21253577 3050486 Negative_regulation TCF19 EPHB2 22312244 1094646 Negative_regulation TCF19 FAS 19876397 2429867 Negative_regulation TCF19 FOXA1 18003659 2031543 Negative_regulation TCF19 FOXO1 21902831 3160699 Negative_regulation TCF19 FOXO1 21902831 3160767 Negative_regulation TCF19 FOXO1 22110478 832169 Negative_regulation TCF19 FOXO1 23737653 1753207 Negative_regulation TCF19 ID1 24369462 1073858 Negative_regulation TCF19 ID1 25115386 2197603 Negative_regulation TCF19 OSR1 24931004 1681237 Negative_regulation TCF19 OSR1 24931004 1681303 Negative_regulation TCF19 PCDH19 19956686 2311647 Negative_regulation TCF19 PCDH8 19956686 2311652 Negative_regulation TCF19 PLAU 23984088 1150926 Negative_regulation TCF19 TNF 21915344 2553380 Negative_regulation TCF19 TNF 21915344 2553436 Negative_regulation TCF19 TNF 22419908 951353 Negative_regulation TCF19 WIF1 20573255 1856500 Negative_regulation TCF19 WIF1 20573255 1856547 Negative_regulation TCF20 ARSA 20858269 1859046 Negative_regulation TCF20 AXIN2 22567304 86252 Negative_regulation TCF20 CCND1 22570653 1673723 Negative_regulation TCF20 CCND1 22751438 541596 Negative_regulation TCF20 CCND1 25143352 785254 Negative_regulation TCF20 CLU 25148511 3002005 Negative_regulation TCF20 EPHB2 21253577 3050489 Negative_regulation TCF20 EPHB2 22312244 1094648 Negative_regulation TCF20 FAS 19876397 2429873 Negative_regulation TCF20 FOXA1 18003659 2031545 Negative_regulation TCF20 FOXO1 21902831 3160700 Negative_regulation TCF20 FOXO1 21902831 3160768 Negative_regulation TCF20 FOXO1 22110478 832171 Negative_regulation TCF20 FOXO1 23737653 1753208 Negative_regulation TCF20 ID1 24369462 1073859 Negative_regulation TCF20 ID1 25115386 2197604 Negative_regulation TCF20 OSR1 24931004 1681239 Negative_regulation TCF20 OSR1 24931004 1681304 Negative_regulation TCF20 PCDH19 19956686 2311658 Negative_regulation TCF20 PCDH8 19956686 2311663 Negative_regulation TCF20 PLAU 23984088 1150928 Negative_regulation TCF20 TNF 21915344 2553381 Negative_regulation TCF20 TNF 21915344 2553437 Negative_regulation TCF20 TNF 22419908 951354 Negative_regulation TCF20 WIF1 20573255 1856501 Negative_regulation TCF20 WIF1 20573255 1856548 Negative_regulation TCF21 ARSA 20858269 1859047 Negative_regulation TCF21 AXIN2 22567304 86254 Negative_regulation TCF21 CCND1 22570653 1673725 Negative_regulation TCF21 CCND1 22751438 541597 Negative_regulation TCF21 CCND1 25143352 785255 Negative_regulation TCF21 CLU 25148511 3002006 Negative_regulation TCF21 EPHB2 21253577 3050492 Negative_regulation TCF21 EPHB2 22312244 1094650 Negative_regulation TCF21 FAS 19876397 2429879 Negative_regulation TCF21 FOXA1 18003659 2031547 Negative_regulation TCF21 FOXO1 21902831 3160701 Negative_regulation TCF21 FOXO1 21902831 3160769 Negative_regulation TCF21 FOXO1 22110478 832173 Negative_regulation TCF21 FOXO1 23737653 1753209 Negative_regulation TCF21 ID1 24369462 1073860 Negative_regulation TCF21 ID1 25115386 2197605 Negative_regulation TCF21 OSR1 24931004 1681241 Negative_regulation TCF21 OSR1 24931004 1681305 Negative_regulation TCF21 PCDH19 19956686 2311669 Negative_regulation TCF21 PCDH8 19956686 2311674 Negative_regulation TCF21 PLAU 23984088 1150930 Negative_regulation TCF21 TNF 21915344 2553382 Negative_regulation TCF21 TNF 21915344 2553438 Negative_regulation TCF21 TNF 22419908 951355 Negative_regulation TCF21 WIF1 20573255 1856502 Negative_regulation TCF21 WIF1 20573255 1856549 Negative_regulation TCF23 ARSA 20858269 1859051 Negative_regulation TCF23 AXIN2 22567304 86262 Negative_regulation TCF23 CCND1 22570653 1673765 Negative_regulation TCF23 CCND1 22751438 541601 Negative_regulation TCF23 CCND1 25143352 785259 Negative_regulation TCF23 CLU 25148511 3002010 Negative_regulation TCF23 EPHB2 21253577 3050504 Negative_regulation TCF23 EPHB2 22312244 1094658 Negative_regulation TCF23 FAS 19876397 2429903 Negative_regulation TCF23 FOXA1 18003659 2031555 Negative_regulation TCF23 FOXO1 21902831 3160705 Negative_regulation TCF23 FOXO1 21902831 3160773 Negative_regulation TCF23 FOXO1 22110478 832181 Negative_regulation TCF23 FOXO1 23737653 1753213 Negative_regulation TCF23 ID1 24369462 1073864 Negative_regulation TCF23 ID1 25115386 2197609 Negative_regulation TCF23 OSR1 24931004 1681249 Negative_regulation TCF23 OSR1 24931004 1681312 Negative_regulation TCF23 PCDH19 19956686 2311713 Negative_regulation TCF23 PCDH8 19956686 2311718 Negative_regulation TCF23 PLAU 23984088 1150938 Negative_regulation TCF23 TNF 21915344 2553386 Negative_regulation TCF23 TNF 21915344 2553442 Negative_regulation TCF23 TNF 22419908 951359 Negative_regulation TCF23 WIF1 20573255 1856510 Negative_regulation TCF23 WIF1 20573255 1856553 Negative_regulation TCF24 ARSA 20858269 1859053 Negative_regulation TCF24 AXIN2 22567304 86266 Negative_regulation TCF24 CCND1 22570653 1673769 Negative_regulation TCF24 CCND1 22751438 541603 Negative_regulation TCF24 CCND1 25143352 785261 Negative_regulation TCF24 CLU 25148511 3002012 Negative_regulation TCF24 EPHB2 21253577 3050510 Negative_regulation TCF24 EPHB2 22312244 1094662 Negative_regulation TCF24 FAS 19876397 2429915 Negative_regulation TCF24 FOXA1 18003659 2031559 Negative_regulation TCF24 FOXO1 21902831 3160707 Negative_regulation TCF24 FOXO1 21902831 3160775 Negative_regulation TCF24 FOXO1 22110478 832185 Negative_regulation TCF24 FOXO1 23737653 1753215 Negative_regulation TCF24 ID1 24369462 1073866 Negative_regulation TCF24 ID1 25115386 2197611 Negative_regulation TCF24 OSR1 24931004 1681253 Negative_regulation TCF24 OSR1 24931004 1681314 Negative_regulation TCF24 PCDH19 19956686 2311735 Negative_regulation TCF24 PCDH8 19956686 2311740 Negative_regulation TCF24 PLAU 23984088 1150942 Negative_regulation TCF24 TNF 21915344 2553388 Negative_regulation TCF24 TNF 21915344 2553444 Negative_regulation TCF24 TNF 22419908 951361 Negative_regulation TCF24 WIF1 20573255 1856512 Negative_regulation TCF24 WIF1 20573255 1856555 Negative_regulation TCF25 ARSA 20858269 1859052 Negative_regulation TCF25 AXIN2 22567304 86264 Negative_regulation TCF25 CCND1 22570653 1673767 Negative_regulation TCF25 CCND1 22751438 541602 Negative_regulation TCF25 CCND1 25143352 785260 Negative_regulation TCF25 CLU 25148511 3002011 Negative_regulation TCF25 EPHB2 21253577 3050507 Negative_regulation TCF25 EPHB2 22312244 1094660 Negative_regulation TCF25 FAS 19876397 2429909 Negative_regulation TCF25 FOXA1 18003659 2031557 Negative_regulation TCF25 FOXO1 21902831 3160706 Negative_regulation TCF25 FOXO1 21902831 3160774 Negative_regulation TCF25 FOXO1 22110478 832183 Negative_regulation TCF25 FOXO1 23737653 1753214 Negative_regulation TCF25 ID1 24369462 1073865 Negative_regulation TCF25 ID1 25115386 2197610 Negative_regulation TCF25 OSR1 24931004 1681251 Negative_regulation TCF25 OSR1 24931004 1681313 Negative_regulation TCF25 PCDH19 19956686 2311724 Negative_regulation TCF25 PCDH8 19956686 2311729 Negative_regulation TCF25 PLAU 23984088 1150940 Negative_regulation TCF25 TNF 21915344 2553387 Negative_regulation TCF25 TNF 21915344 2553443 Negative_regulation TCF25 TNF 22419908 951360 Negative_regulation TCF25 WIF1 20573255 1856511 Negative_regulation TCF25 WIF1 20573255 1856554 Negative_regulation TCF3 ARSA 20858269 1859048 Negative_regulation TCF3 AXIN2 22567304 86256 Negative_regulation TCF3 CCND1 22570653 1673727 Negative_regulation TCF3 CCND1 22751438 541598 Negative_regulation TCF3 CCND1 25143352 785256 Negative_regulation TCF3 CLU 25148511 3002007 Negative_regulation TCF3 EPHB2 21253577 3050495 Negative_regulation TCF3 EPHB2 22111016 1151824 Negative_regulation TCF3 EPHB2 22312244 1094652 Negative_regulation TCF3 FAS 19876397 2429885 Negative_regulation TCF3 FOXA1 18003659 2031549 Negative_regulation TCF3 FOXO1 21902831 3160702 Negative_regulation TCF3 FOXO1 21902831 3160770 Negative_regulation TCF3 FOXO1 22110478 832175 Negative_regulation TCF3 FOXO1 23737653 1753210 Negative_regulation TCF3 ID1 24369462 1073861 Negative_regulation TCF3 ID1 24429391 2186757 Negative_regulation TCF3 ID1 25115386 2197606 Negative_regulation TCF3 OSR1 24931004 1681243 Negative_regulation TCF3 OSR1 24931004 1681306 Negative_regulation TCF3 PCDH19 19956686 2311680 Negative_regulation TCF3 PCDH8 19956686 2311685 Negative_regulation TCF3 PLAU 23984088 1150932 Negative_regulation TCF3 TNF 21915344 2553383 Negative_regulation TCF3 TNF 21915344 2553439 Negative_regulation TCF3 TNF 22419908 951356 Negative_regulation TCF3 WIF1 20573255 1856503 Negative_regulation TCF3 WIF1 20573255 1856550 Negative_regulation TCF4 ARSA 20858269 1859049 Negative_regulation TCF4 AXIN2 22567304 86258 Negative_regulation TCF4 CCND1 22570653 1673729 Negative_regulation TCF4 CCND1 22751438 541599 Negative_regulation TCF4 CCND1 25143352 785257 Negative_regulation TCF4 CLU 25148511 3002008 Negative_regulation TCF4 EPHB2 21253577 3050498 Negative_regulation TCF4 EPHB2 22312244 1094654 Negative_regulation TCF4 FAS 19876397 2429891 Negative_regulation TCF4 FOXA1 18003659 2031551 Negative_regulation TCF4 FOXO1 21902831 3160703 Negative_regulation TCF4 FOXO1 21902831 3160771 Negative_regulation TCF4 FOXO1 22110478 832177 Negative_regulation TCF4 FOXO1 23737653 1753211 Negative_regulation TCF4 ID1 24369462 1073862 Negative_regulation TCF4 ID1 25115386 2197607 Negative_regulation TCF4 OSR1 24931004 1681245 Negative_regulation TCF4 OSR1 24931004 1681307 Negative_regulation TCF4 PCDH19 19956686 2311691 Negative_regulation TCF4 PCDH8 19956686 2311696 Negative_regulation TCF4 PLAU 23984088 1150934 Negative_regulation TCF4 TNF 21915344 2553384 Negative_regulation TCF4 TNF 21915344 2553440 Negative_regulation TCF4 TNF 22419908 951357 Negative_regulation TCF4 WIF1 20573255 1856504 Negative_regulation TCF4 WIF1 20573255 1856551 Negative_regulation TCF7 ARSA 20858269 1859050 Negative_regulation TCF7 AXIN2 22567304 86260 Negative_regulation TCF7 CCND1 22570653 1673731 Negative_regulation TCF7 CCND1 22751438 541600 Negative_regulation TCF7 CCND1 25143352 785258 Negative_regulation TCF7 CLU 25148511 3002009 Negative_regulation TCF7 EPHB2 21253577 3050501 Negative_regulation TCF7 EPHB2 22312244 1094656 Negative_regulation TCF7 FAS 19876397 2429897 Negative_regulation TCF7 FOXA1 18003659 2031553 Negative_regulation TCF7 FOXO1 21902831 3160704 Negative_regulation TCF7 FOXO1 21902831 3160772 Negative_regulation TCF7 FOXO1 22110478 832179 Negative_regulation TCF7 FOXO1 23737653 1753212 Negative_regulation TCF7 ID1 24369462 1073863 Negative_regulation TCF7 ID1 25115386 2197608 Negative_regulation TCF7 OSR1 24931004 1681247 Negative_regulation TCF7 OSR1 24931004 1681308 Negative_regulation TCF7 PCDH19 19956686 2311702 Negative_regulation TCF7 PCDH8 19956686 2311707 Negative_regulation TCF7 PLAU 23984088 1150936 Negative_regulation TCF7 TNF 21915344 2553385 Negative_regulation TCF7 TNF 21915344 2553441 Negative_regulation TCF7 TNF 22419908 951358 Negative_regulation TCF7 WIF1 20573255 1856505 Negative_regulation TCF7 WIF1 20573255 1856552 Negative_regulation TCF7 WNT7A 22179044 1928046 Negative_regulation TCF7L2 AXIN2 20122174 1853296 Negative_regulation TCF7L2 AXIN2 20122174 1853297 Negative_regulation TCF7L2 AXIN2 20122174 1853298 Negative_regulation TCF7L2 AXIN2 20122174 1853299 Negative_regulation TCF7L2 AXIN2 20122174 1853300 Negative_regulation TCF7L2 AXIN2 20122174 1853315 Negative_regulation TCF7L2 AXIN2 20122174 1853316 Negative_regulation TCF7L2 AXIN2 20122174 1853324 Negative_regulation TCF7L2 TNFSF10 20661477 2456790 Negative_regulation TCF7L2 TNFSF10 20661477 2456858 Negative_regulation TCN1 PIK3CA 22590527 2640995 Negative_regulation TCN1 PIK3R1 22590527 2640996 Negative_regulation TCN1 SHC1 8551221 1595737 Negative_regulation TDGF1P3 CD14 7535337 1590139 Negative_regulation TDGF1P3 TNF 18567623 451665 Negative_regulation TEC CHI3L1 22238378 2071483 Negative_regulation TECR FOXO1 24380076 864743 Negative_regulation TECR TNF 20824160 1911976 Negative_regulation TECR TNF 20824160 1911977 Negative_regulation TECR TNF 21473788 1658070 Negative_regulation TECR TNF 22031828 2565225 Negative_regulation TECR TNF 22031828 2565234 Negative_regulation TECR TNF 25013357 1498331 Negative_regulation TEF S100B 20672023 512965 Negative_regulation TERF1 EPHB2 23360994 1934889 Negative_regulation TERF2 CAPN8 23056924 139849 Negative_regulation TERF2 EPHB2 23360994 1934890 Negative_regulation TERF2IP CAPN8 23056924 140189 Negative_regulation TERF2IP EPHB2 23360994 1934893 Negative_regulation TERT STAT4 21738677 2533228 Negative_regulation TERT TNF 21485744 734854 Negative_regulation TERT ZFP57 25032857 577010 Negative_regulation TERT ZFP57 25032857 577011 Negative_regulation TERT ZFP57 25032857 577295 Negative_regulation TESC EPHB2 22852078 1689386 Negative_regulation TESC MAP2K6 22852078 1689392 Negative_regulation TET2 PGC 24322296 2096571 Negative_regulation TET2 PGC 24322296 2096591 Negative_regulation TET2 PGC 24322296 2096627 Negative_regulation TET3 PGC 24322296 2096605 Negative_regulation TET3 PGC 24322296 2096628 Negative_regulation TF AGTR2 3294861 1426254 Negative_regulation TF ATR 6309862 1431133 Negative_regulation TF CA2 2887575 1424387 Negative_regulation TF CNTN4 20360857 2444909 Negative_regulation TF CPZ 22272874 1660770 Negative_regulation TF CTBS 22272874 1660771 Negative_regulation TF DNM1 20551131 2054436 Negative_regulation TF DNM1 20551131 2054439 Negative_regulation TF DNM2 20551131 2054437 Negative_regulation TF DNM2 20551131 2054440 Negative_regulation TF DNM3 20551131 2054435 Negative_regulation TF DNM3 20551131 2054438 Negative_regulation TF EHD4 17233914 279486 Negative_regulation TF MTOR 17640392 1002335 Negative_regulation TF TMEM100 22857383 3084638 Negative_regulation TF TMEM101 22857383 3084704 Negative_regulation TF TMEM102 22857383 3084667 Negative_regulation TF TMEM104 22857383 3084647 Negative_regulation TF TMEM105 22857383 3084669 Negative_regulation TF TMEM107 22857383 3084684 Negative_regulation TF TMEM108 22857383 3084697 Negative_regulation TF TMEM109 22857383 3084706 Negative_regulation TF TMEM11 22857383 3084590 Negative_regulation TF TMEM110 22857383 3084718 Negative_regulation TF TMEM114 22857383 3084732 Negative_regulation TF TMEM115 22857383 3084712 Negative_regulation TF TMEM116 22857383 3084618 Negative_regulation TF TMEM117 22857383 3084626 Negative_regulation TF TMEM119 22857383 3084678 Negative_regulation TF TMEM121 22857383 3084600 Negative_regulation TF TMEM123 22857383 3084714 Negative_regulation TF TMEM125 22857383 3084692 Negative_regulation TF TMEM127 22857383 3084648 Negative_regulation TF TMEM128 22857383 3084689 Negative_regulation TF TMEM129 22857383 3084621 Negative_regulation TF TMEM130 22857383 3084629 Negative_regulation TF TMEM131 22857383 3084716 Negative_regulation TF TMEM133 22857383 3084612 Negative_regulation TF TMEM134 22857383 3084651 Negative_regulation TF TMEM135 22857383 3084652 Negative_regulation TF TMEM136 22857383 3084693 Negative_regulation TF TMEM138 22857383 3084671 Negative_regulation TF TMEM139 22857383 3084609 Negative_regulation TF TMEM140 22857383 3084606 Negative_regulation TF TMEM141 22857383 3084690 Negative_regulation TF TMEM143 22857383 3084636 Negative_regulation TF TMEM144 22857383 3084641 Negative_regulation TF TMEM145 22857383 3084670 Negative_regulation TF TMEM147 22857383 3084717 Negative_regulation TF TMEM154 22857383 3084662 Negative_regulation TF TMEM155 22857383 3084660 Negative_regulation TF TMEM156 22857383 3084656 Negative_regulation TF TMEM158 22857383 3084715 Negative_regulation TF TMEM159 22857383 3084713 Negative_regulation TF TMEM160 22857383 3084649 Negative_regulation TF TMEM163 22857383 3084628 Negative_regulation TF TMEM164 22857383 3084655 Negative_regulation TF TMEM165 22857383 3084720 Negative_regulation TF TMEM168 22857383 3084643 Negative_regulation TF TMEM169 22857383 3084620 Negative_regulation TF TMEM17 22857383 3084666 Negative_regulation TF TMEM171 22857383 3084672 Negative_regulation TF TMEM173 22857383 3084681 Negative_regulation TF TMEM174 22857383 3084687 Negative_regulation TF TMEM175 22857383 3084705 Negative_regulation TF TMEM177 22857383 3084685 Negative_regulation TF TMEM179 22857383 3084597 Negative_regulation TF TMEM18 22857383 3084625 Negative_regulation TF TMEM180 22857383 3084654 Negative_regulation TF TMEM181 22857383 3084601 Negative_regulation TF TMEM182 22857383 3084658 Negative_regulation TF TMEM186 22857383 3084615 Negative_regulation TF TMEM187 22857383 3084585 Negative_regulation TF TMEM189 22857383 3084589 Negative_regulation TF TMEM19 22857383 3084637 Negative_regulation TF TMEM190 22857383 3084711 Negative_regulation TF TMEM192 22857383 3084668 Negative_regulation TF TMEM196 22857383 3084610 Negative_regulation TF TMEM198 22857383 3084733 Negative_regulation TF TMEM199 22857383 3084593 Negative_regulation TF TMEM2 22857383 3084581 Negative_regulation TF TMEM201 22857383 3084735 Negative_regulation TF TMEM202 22857383 3084737 Negative_regulation TF TMEM203 22857383 3084691 Negative_regulation TF TMEM204 22857383 3084586 Negative_regulation TF TMEM205 22857383 3084710 Negative_regulation TF TMEM206 22857383 3084635 Negative_regulation TF TMEM207 22857383 3084734 Negative_regulation TF TMEM208 22857383 3084616 Negative_regulation TF TMEM209 22857383 3084607 Negative_regulation TF TMEM210 22857383 3084740 Negative_regulation TF TMEM211 22857383 3084736 Negative_regulation TF TMEM212 22857383 3084741 Negative_regulation TF TMEM213 22857383 3084673 Negative_regulation TF TMEM214 22857383 3084646 Negative_regulation TF TMEM215 22857383 3084739 Negative_regulation TF TMEM216 22857383 3084617 Negative_regulation TF TMEM217 22857383 3084602 Negative_regulation TF TMEM218 22857383 3084675 Negative_regulation TF TMEM219 22857383 3084623 Negative_regulation TF TMEM220 22857383 3084738 Negative_regulation TF TMEM221 22857383 3084608 Negative_regulation TF TMEM222 22857383 3084627 Negative_regulation TF TMEM223 22857383 3084698 Negative_regulation TF TMEM225 22857383 3084729 Negative_regulation TF TMEM230 22857383 3084588 Negative_regulation TF TMEM231 22857383 3084743 Negative_regulation TF TMEM232 22857383 3084744 Negative_regulation TF TMEM233 22857383 3084742 Negative_regulation TF TMEM234 22857383 3084708 Negative_regulation TF TMEM235 22857383 3084677 Negative_regulation TF TMEM236 22857383 3084611 Negative_regulation TF TMEM237 22857383 3084587 Negative_regulation TF TMEM238 22857383 3084745 Negative_regulation TF TMEM239 22857383 3084746 Negative_regulation TF TMEM240 22857383 3084622 Negative_regulation TF TMEM241 22857383 3084722 Negative_regulation TF TMEM242 22857383 3084592 Negative_regulation TF TMEM243 22857383 3084604 Negative_regulation TF TMEM244 22857383 3084603 Negative_regulation TF TMEM245 22857383 3084584 Negative_regulation TF TMEM246 22857383 3084686 Negative_regulation TF TMEM247 22857383 3084747 Negative_regulation TF TMEM248 22857383 3084631 Negative_regulation TF TMEM249 22857383 3084748 Negative_regulation TF TMEM25 22857383 3084645 Negative_regulation TF TMEM251 22857383 3084599 Negative_regulation TF TMEM252 22857383 3084700 Negative_regulation TF TMEM253 22857383 3084731 Negative_regulation TF TMEM254 22857383 3084642 Negative_regulation TF TMEM256 22857383 3084703 Negative_regulation TF TMEM257 22857383 3084639 Negative_regulation TF TMEM258 22857383 3084580 Negative_regulation TF TMEM259 22857383 3084591 Negative_regulation TF TMEM26 22857383 3084701 Negative_regulation TF TMEM260 22857383 3084598 Negative_regulation TF TMEM261 22857383 3084719 Negative_regulation TF TMEM27 22857383 3084709 Negative_regulation TF TMEM31 22857383 3084702 Negative_regulation TF TMEM33 22857383 3084633 Negative_regulation TF TMEM35 22857383 3084644 Negative_regulation TF TMEM37 22857383 3084594 Negative_regulation TF TMEM40 22857383 3084640 Negative_regulation TF TMEM42 22857383 3084696 Negative_regulation TF TMEM43 22857383 3084699 Negative_regulation TF TMEM44 22857383 3084619 Negative_regulation TF TMEM47 22857383 3084595 Negative_regulation TF TMEM5 22857383 3084583 Negative_regulation TF TMEM51 22857383 3084632 Negative_regulation TF TMEM52 22857383 3084680 Negative_regulation TF TMEM53 22857383 3084653 Negative_regulation TF TMEM54 22857383 3084613 Negative_regulation TF TMEM56 22857383 3084661 Negative_regulation TF TMEM57 22857383 3084634 Negative_regulation TF TMEM59 22857383 3084582 Negative_regulation TF TMEM60 22857383 3084605 Negative_regulation TF TMEM61 22857383 3084674 Negative_regulation TF TMEM62 22857383 3084657 Negative_regulation TF TMEM64 22857383 3084630 Negative_regulation TF TMEM65 22857383 3084624 Negative_regulation TF TMEM66 22857383 3084707 Negative_regulation TF TMEM67 22857383 3084695 Negative_regulation TF TMEM68 22857383 3084663 Negative_regulation TF TMEM69 22857383 3084682 Negative_regulation TF TMEM70 22857383 3084650 Negative_regulation TF TMEM71 22857383 3084664 Negative_regulation TF TMEM72 22857383 3084721 Negative_regulation TF TMEM74 22857383 3084659 Negative_regulation TF TMEM75 22857383 3084723 Negative_regulation TF TMEM78 22857383 3084724 Negative_regulation TF TMEM79 22857383 3084688 Negative_regulation TF TMEM80 22857383 3084676 Negative_regulation TF TMEM81 22857383 3084725 Negative_regulation TF TMEM82 22857383 3084726 Negative_regulation TF TMEM88 22857383 3084727 Negative_regulation TF TMEM89 22857383 3084728 Negative_regulation TF TMEM9 22857383 3084596 Negative_regulation TF TMEM91 22857383 3084730 Negative_regulation TF TMEM92 22857383 3084665 Negative_regulation TF TMEM95 22857383 3084679 Negative_regulation TF TMEM97 22857383 3084683 Negative_regulation TF TMEM98 22857383 3084614 Negative_regulation TF TMEM99 22857383 3084694 Negative_regulation TFAP2A MAP2K6 19701232 8045 Negative_regulation TFEB EPHB2 25375375 578932 Negative_regulation TFF3 TNF 24886810 1127309 Negative_regulation TFPI F3 20140262 2440285 Negative_regulation TFPI2 DNMT1 18053161 370970 Negative_regulation TFPI2 LCT 23703216 2088606 Negative_regulation TFPI2 MTOR 16953237 427982 Negative_regulation TFPI2 MTOR 21513566 1026047 Negative_regulation TFPI2 MTOR 21513566 1026053 Negative_regulation TGFBR1 CTGF 20195389 1478634 Negative_regulation TGFBR2 CCND1 25473455 1144953 Negative_regulation TGM2 ADAM11 19619546 850756 Negative_regulation TGM2 ADAM11 24098122 3064352 Negative_regulation TGM2 ADO 15279680 390103 Negative_regulation TGM2 CAV1 24236206 2878887 Negative_regulation TGM2 E2F1 23064266 1928646 Negative_regulation TGM2 E2F2 23064266 1928647 Negative_regulation TGM2 E2F3 23064266 1928648 Negative_regulation TGM2 E2F4 23064266 1928649 Negative_regulation TGM2 E2F5 23064266 1928650 Negative_regulation TGM2 E2F6 23064266 1928651 Negative_regulation TGM2 E2F7 23064266 1928644 Negative_regulation TGM2 E2F8 23064266 1928645 Negative_regulation TGM2 FCAR 22451718 1567868 Negative_regulation TGM2 HSF4 25009701 206367 Negative_regulation TGM2 HSF4 25009701 206390 Negative_regulation TGM2 IL4 20733031 1559611 Negative_regulation TGM2 MYCN 21698133 2324852 Negative_regulation TGM2 MYCN 21698133 2324853 Negative_regulation TGM2 MYLIP 22294552 2179639 Negative_regulation TH EPHB2 24260176 2882612 Negative_regulation THBD ARSA 20877628 2475400 Negative_regulation THBD EDN2 25599087 33748 Negative_regulation THBD TNF 12617738 658447 Negative_regulation THBD TNF 2499653 1577007 Negative_regulation THBD TNF 3137305 1580324 Negative_regulation THBS1 ADAMTS1 20546609 256259 Negative_regulation THBS1 ADAMTS1 20546609 256263 Negative_regulation THBS1 ADAMTS1 20546609 256267 Negative_regulation THBS1 ADAMTS1 20546609 256270 Negative_regulation THBS1 CTGF 23950936 2832982 Negative_regulation THBS1 EPHB2 21453480 855659 Negative_regulation THBS1 ID1 16594992 274377 Negative_regulation THBS1 MAP2K6 21453480 855665 Negative_regulation THRSP IL1B 20504330 329084 Negative_regulation TIE1 ANGPT1 17341311 279544 Negative_regulation TIE1 ANGPT1 19435476 659195 Negative_regulation TIE1 ANGPT1 19435476 659206 Negative_regulation TIE1 ANGPT1 21113176 12113 Negative_regulation TIE1 ANGPT1 22454630 832657 Negative_regulation TIE1 ANGPT1 23036162 660350 Negative_regulation TIE1 ANGPT1 23405099 2751796 Negative_regulation TIE1 ANGPT1 23405099 2751797 Negative_regulation TIE1 ANGPT1 24367525 2900129 Negative_regulation TIMP1 CTGF 23755313 2371934 Negative_regulation TIMP1 MMP28 23154389 548138 Negative_regulation TIMP1 MMP28 23484133 179674 Negative_regulation TIMP1 MMP28 23986797 83125 Negative_regulation TIMP1 MMP28 24278882 1498549 Negative_regulation TIMP1 MMP28 24675764 2372490 Negative_regulation TIMP1 MMP28 24859313 1143500 Negative_regulation TIMP1 MMP7 22528051 615995 Negative_regulation TIMP1 MMP7 23154389 548153 Negative_regulation TIMP1 MMP7 23484133 179689 Negative_regulation TIMP1 MMP7 23986797 83140 Negative_regulation TIMP1 MMP7 24278882 1498564 Negative_regulation TIMP1 MMP7 24675764 2372505 Negative_regulation TIMP1 TLR7 23223421 91302 Negative_regulation TIMP1 TNF 16106101 1740036 Negative_regulation TIMP1 TNF 22291799 95059 Negative_regulation TIMP1 TNF 22460094 1735348 Negative_regulation TIMP1 TNF 23967215 2834937 Negative_regulation TIMP1 TNF 24278882 1498544 Negative_regulation TIMP2 IGFBP1 25289643 3012517 Negative_regulation TIMP2 MMP28 24395652 3205322 Negative_regulation TIMP2 MMP7 23408109 843074 Negative_regulation TIMP2 MMP7 23408109 843075 Negative_regulation TIMP2 MMP7 23408109 843076 Negative_regulation TIMP2 MMP7 24395652 3205337 Negative_regulation TIMP2 TNF 16106101 1740037 Negative_regulation TIMP3 ADAMTS1 23071766 2704080 Negative_regulation TIMP3 CLU 23257616 31095 Negative_regulation TIMP3 IL1B 23717664 2798683 Negative_regulation TIMP4 CTGF 23755313 2371946 Negative_regulation TINF2 EPHB2 23360994 1934891 Negative_regulation TJP1 CAPN8 22931549 2233343 Negative_regulation TJP1 CAPN8 22931549 2233415 Negative_regulation TJP1 CTGF 23451286 2758551 Negative_regulation TJP1 EPHB2 24409324 2906896 Negative_regulation TJP1 TNF 17971210 3108443 Negative_regulation TJP1 TNF 19772664 313170 Negative_regulation TJP1 TNF 20693346 716067 Negative_regulation TJP2 TNF 19772664 313171 Negative_regulation TJP3 TNF 19772664 313172 Negative_regulation TLN1 ITGB2 22110576 2572229 Negative_regulation TLN2 ITGB2 22110576 2572237 Negative_regulation TLR1 CD14 21789185 2537933 Negative_regulation TLR1 MAP2K6 23405061 2751655 Negative_regulation TLR1 MMP28 18762577 1355991 Negative_regulation TLR1 MMP7 18762577 1356006 Negative_regulation TLR1 TMEM100 23429360 835118 Negative_regulation TLR1 TMEM156 23429360 835136 Negative_regulation TLR1 TMEM211 23429360 835216 Negative_regulation TLR1 TMEM213 23429360 835153 Negative_regulation TLR1 TNF 23497095 2236055 Negative_regulation TLR10 CD14 21789185 2537941 Negative_regulation TLR10 MMP28 18762577 1356167 Negative_regulation TLR10 MMP7 18762577 1356182 Negative_regulation TLR10 TMEM100 23429360 836470 Negative_regulation TLR10 TMEM156 23429360 836488 Negative_regulation TLR10 TMEM211 23429360 836568 Negative_regulation TLR10 TMEM213 23429360 836505 Negative_regulation TLR10 TNF 23497095 2236063 Negative_regulation TLR2 CD14 20011115 3045866 Negative_regulation TLR2 CD14 21789185 2537934 Negative_regulation TLR2 FOXO1 24265696 2884916 Negative_regulation TLR2 MAP2K6 15125785 369400 Negative_regulation TLR2 MAP2K6 15125785 369403 Negative_regulation TLR2 MMP28 18762577 1356013 Negative_regulation TLR2 MMP7 18762577 1356028 Negative_regulation TLR2 TLR7 23055935 3059658 Negative_regulation TLR2 TMEM100 23429360 835287 Negative_regulation TLR2 TMEM156 23429360 835305 Negative_regulation TLR2 TMEM211 23429360 835385 Negative_regulation TLR2 TMEM213 23429360 835322 Negative_regulation TLR2 TNF 16277694 104786 Negative_regulation TLR2 TNF 19966777 1960912 Negative_regulation TLR2 TNF 23497095 2236056 Negative_regulation TLR3 CD14 21789185 2537935 Negative_regulation TLR3 JAG1 25025040 194654 Negative_regulation TLR3 MMP28 18762577 1356035 Negative_regulation TLR3 MMP7 18762577 1356050 Negative_regulation TLR3 TMEM100 23429360 835456 Negative_regulation TLR3 TMEM156 23429360 835474 Negative_regulation TLR3 TMEM211 23429360 835554 Negative_regulation TLR3 TMEM213 23429360 835491 Negative_regulation TLR3 TNF 23497095 2236057 Negative_regulation TLR4 ALOX5 25116953 2996580 Negative_regulation TLR4 CAPN8 24489676 2915597 Negative_regulation TLR4 CAPN8 24489676 2915713 Negative_regulation TLR4 CD14 14517279 1529117 Negative_regulation TLR4 CD14 21789185 2537936 Negative_regulation TLR4 CLU 21970823 1659863 Negative_regulation TLR4 CLU 22768318 2660570 Negative_regulation TLR4 CLU 22768318 2660684 Negative_regulation TLR4 CLU 23635013 1480671 Negative_regulation TLR4 CLU 23635013 1480675 Negative_regulation TLR4 CLU 23635013 1480676 Negative_regulation TLR4 CLU 23649808 1405123 Negative_regulation TLR4 CLU 23690990 2793999 Negative_regulation TLR4 CLU 23936008 2828955 Negative_regulation TLR4 CLU 24058497 2847733 Negative_regulation TLR4 CLU 24387801 1162647 Negative_regulation TLR4 CLU 24445575 1940428 Negative_regulation TLR4 CLU 25342887 743392 Negative_regulation TLR4 CLU 25343247 3018989 Negative_regulation TLR4 CLU 25343247 3018990 Negative_regulation TLR4 CLU 25343247 3019004 Negative_regulation TLR4 CLU 25343247 3019005 Negative_regulation TLR4 CLU PMC4184146 2236345 Negative_regulation TLR4 EGLN3 25161887 1888481 Negative_regulation TLR4 EPHB2 21909400 2552023 Negative_regulation TLR4 EPHB2 21909400 2552031 Negative_regulation TLR4 FAS 24191253 184763 Negative_regulation TLR4 FOXO1 24265696 2884918 Negative_regulation TLR4 JAG1 25025040 194655 Negative_regulation TLR4 MAP2K6 21909400 2551974 Negative_regulation TLR4 MMP28 18762577 1356057 Negative_regulation TLR4 MMP7 18762577 1356072 Negative_regulation TLR4 TLR7 23840549 2815148 Negative_regulation TLR4 TMEM100 23429360 835625 Negative_regulation TLR4 TMEM156 23429360 835643 Negative_regulation TLR4 TMEM211 23429360 835723 Negative_regulation TLR4 TMEM213 23429360 835660 Negative_regulation TLR4 TNF 16277694 104787 Negative_regulation TLR4 TNF 16322770 3039072 Negative_regulation TLR4 TNF 19997599 2432943 Negative_regulation TLR4 TNF 22485093 956794 Negative_regulation TLR4 TNF 23497095 2236058 Negative_regulation TLR4 TNF 24345260 809487 Negative_regulation TLR5 CD14 21789185 2537937 Negative_regulation TLR5 MMP28 18762577 1356079 Negative_regulation TLR5 MMP7 18762577 1356094 Negative_regulation TLR5 TLR7 23055935 3059668 Negative_regulation TLR5 TMEM100 23429360 835794 Negative_regulation TLR5 TMEM156 23429360 835812 Negative_regulation TLR5 TMEM211 23429360 835892 Negative_regulation TLR5 TMEM213 23429360 835829 Negative_regulation TLR5 TNF 23497095 2236059 Negative_regulation TLR6 CD14 21789185 2537942 Negative_regulation TLR6 MMP28 18762577 1356189 Negative_regulation TLR6 MMP7 18762577 1356204 Negative_regulation TLR6 TMEM100 23429360 836639 Negative_regulation TLR6 TMEM156 23429360 836657 Negative_regulation TLR6 TMEM211 23429360 836737 Negative_regulation TLR6 TMEM213 23429360 836674 Negative_regulation TLR6 TNF 23497095 2236064 Negative_regulation TLR7 ABCA1 22315310 721108 Negative_regulation TLR7 ABCG1 22315310 721109 Negative_regulation TLR7 ACD 25118589 1944864 Negative_regulation TLR7 ADIPOQ 21960997 980026 Negative_regulation TLR7 AHR 19703987 1556076 Negative_regulation TLR7 AKT1 21738617 2532855 Negative_regulation TLR7 AKT1 21738617 2532983 Negative_regulation TLR7 AKT2 21738617 2532856 Negative_regulation TLR7 AKT2 21738617 2532984 Negative_regulation TLR7 AKT3 21738617 2532857 Negative_regulation TLR7 AKT3 21738617 2532985 Negative_regulation TLR7 BCL10 23799152 2807222 Negative_regulation TLR7 BCL2 21850221 2542632 Negative_regulation TLR7 BTK 23967355 2837709 Negative_regulation TLR7 CCDC88A 25610519 3225739 Negative_regulation TLR7 CD14 21789185 2537938 Negative_regulation TLR7 CD180 22661952 957266 Negative_regulation TLR7 CD200 22615569 3056798 Negative_regulation TLR7 CD200 22615569 3056799 Negative_regulation TLR7 CD200 22615569 3056800 Negative_regulation TLR7 CD80 23691339 1151638 Negative_regulation TLR7 CD86 24842926 1050032 Negative_regulation TLR7 CD9 22448280 2613596 Negative_regulation TLR7 CDC73 20976181 2479202 Negative_regulation TLR7 CDKN2A 23549168 543160 Negative_regulation TLR7 CISH 18268035 1549260 Negative_regulation TLR7 CISH 23078795 1617573 Negative_regulation TLR7 CLEC4A 24911430 1146444 Negative_regulation TLR7 CTR9 20976181 2479203 Negative_regulation TLR7 CTRL 22934974 3210470 Negative_regulation TLR7 CXCL10 23144947 2715079 Negative_regulation TLR7 DDX58 23223197 3221940 Negative_regulation TLR7 DEFB103B 21809339 808401 Negative_regulation TLR7 DES 24650925 1159374 Negative_regulation TLR7 DOK3 22761938 2659413 Negative_regulation TLR7 E2F1 23162766 2161671 Negative_regulation TLR7 HLA-DRA 23691339 1151639 Negative_regulation TLR7 HLA-DRB1 23691339 1151640 Negative_regulation TLR7 IARS 16230478 1538117 Negative_regulation TLR7 IARS 16230478 1538119 Negative_regulation TLR7 IARS 22934974 3210471 Negative_regulation TLR7 IARS 24303065 2887974 Negative_regulation TLR7 IARS 25203514 3006373 Negative_regulation TLR7 IFNAR2 19624844 116099 Negative_regulation TLR7 IGKV1-27 24459463 910845 Negative_regulation TLR7 IGKV1-27 24917867 913054 Negative_regulation TLR7 IKBKG 23825957 3062903 Negative_regulation TLR7 IL10 20625435 2455088 Negative_regulation TLR7 IL10 20625435 2455147 Negative_regulation TLR7 IL10 21464967 2510719 Negative_regulation TLR7 IL10 22928050 2681689 Negative_regulation TLR7 INPP5D 23078795 1617360 Negative_regulation TLR7 INS 18556339 729013 Negative_regulation TLR7 IRAK1 15767370 1534884 Negative_regulation TLR7 IRAK1 15767370 1534903 Negative_regulation TLR7 IRAK1 21188194 139520 Negative_regulation TLR7 IRAK1 22992343 1866840 Negative_regulation TLR7 IRAK1 23078795 1617540 Negative_regulation TLR7 IRAK2 12566418 1525890 Negative_regulation TLR7 IRAK2 19564352 1555313 Negative_regulation TLR7 IRAK2 22992343 1866841 Negative_regulation TLR7 IRAK3 15809356 1535393 Negative_regulation TLR7 IRAK3 15809356 1535420 Negative_regulation TLR7 IRAK3 21390243 1049782 Negative_regulation TLR7 IRAK3 22928050 2681688 Negative_regulation TLR7 IRAK3 22928050 2681773 Negative_regulation TLR7 IRAK3 22992343 1866837 Negative_regulation TLR7 IRAK3 24009773 2841755 Negative_regulation TLR7 IRAK4 17470642 1545444 Negative_regulation TLR7 IRAK4 17470642 1545445 Negative_regulation TLR7 IRAK4 17470642 1545516 Negative_regulation TLR7 IRAK4 17485511 1545708 Negative_regulation TLR7 IRAK4 21197425 979775 Negative_regulation TLR7 IRAK4 22992343 1866838 Negative_regulation TLR7 IRAK4 23994464 1051328 Negative_regulation TLR7 IRF4 19079230 1917729 Negative_regulation TLR7 IRF4 20886024 1748351 Negative_regulation TLR7 IRF4 20886024 1748375 Negative_regulation TLR7 ITGAM 23451151 2758266 Negative_regulation TLR7 LEO1 20976181 2479206 Negative_regulation TLR7 LILRA2 22479404 2615199 Negative_regulation TLR7 LTB 24634497 1624503 Negative_regulation TLR7 LY96 25415198 3224409 Negative_regulation TLR7 MALT1 23799152 2807221 Negative_regulation TLR7 MAPKAP1 24740015 2954418 Negative_regulation TLR7 MERTK 22957057 2686538 Negative_regulation TLR7 MERTK 24688608 2208356 Negative_regulation TLR7 MLST8 24740015 2954419 Negative_regulation TLR7 MMP1 18762577 1356102 Negative_regulation TLR7 MMP10 18762577 1356103 Negative_regulation TLR7 MMP11 18762577 1356104 Negative_regulation TLR7 MMP12 18762577 1356105 Negative_regulation TLR7 MMP13 18762577 1356106 Negative_regulation TLR7 MMP14 18762577 1356107 Negative_regulation TLR7 MMP15 18762577 1356108 Negative_regulation TLR7 MMP16 18762577 1356109 Negative_regulation TLR7 MMP17 18762577 1356110 Negative_regulation TLR7 MMP19 18762577 1356111 Negative_regulation TLR7 MMP2 18762577 1356112 Negative_regulation TLR7 MMP20 18762577 1356113 Negative_regulation TLR7 MMP21 18762577 1356100 Negative_regulation TLR7 MMP24 18762577 1356114 Negative_regulation TLR7 MMP25 18762577 1356097 Negative_regulation TLR7 MMP26 18762577 1356098 Negative_regulation TLR7 MMP27 18762577 1356099 Negative_regulation TLR7 MMP28 18762577 1356101 Negative_regulation TLR7 MMP3 18762577 1356115 Negative_regulation TLR7 MMP7 18762577 1356116 Negative_regulation TLR7 MMP8 18762577 1356117 Negative_regulation TLR7 MMP9 18762577 1356118 Negative_regulation TLR7 MMP9 23940584 2831846 Negative_regulation TLR7 MRE11A 25118589 1944017 Negative_regulation TLR7 MSH2 24009773 2841756 Negative_regulation TLR7 MSH3 24009773 2841757 Negative_regulation TLR7 MSH4 24009773 2841758 Negative_regulation TLR7 MSH5 24009773 2841759 Negative_regulation TLR7 MSH6 24009773 2841760 Negative_regulation TLR7 MTA1 25117662 2996833 Negative_regulation TLR7 MTA2 25117662 2996834 Negative_regulation TLR7 MTA3 25117662 2996832 Negative_regulation TLR7 MTOR 24740015 2954421 Negative_regulation TLR7 MYD88 22615780 2643638 Negative_regulation TLR7 MYD88 22661952 957267 Negative_regulation TLR7 MYLIP 20680494 1654653 Negative_regulation TLR7 MYLIP 21941583 633239 Negative_regulation TLR7 MYLIP 22518321 1079128 Negative_regulation TLR7 MYLIP 22684508 2075771 Negative_regulation TLR7 MYLIP 22992343 1866839 Negative_regulation TLR7 MYLIP 23078795 1617395 Negative_regulation TLR7 MYLIP 23448136 245418 Negative_regulation TLR7 MYLIP 23506673 1036546 Negative_regulation TLR7 MYLIP 24690917 2947293 Negative_regulation TLR7 MYLIP 24971086 896292 Negative_regulation TLR7 MYLIP 25484882 921404 Negative_regulation TLR7 NAALADL1 24236103 2878517 Negative_regulation TLR7 NDP 21964925 600375 Negative_regulation TLR7 NELFCD 21966467 2559018 Negative_regulation TLR7 NEU1 25187624 761426 Negative_regulation TLR7 NFKB1 23506673 1036619 Negative_regulation TLR7 NINJ1 PMC3504845 661142 Negative_regulation TLR7 NLRP12 23758787 1649490 Negative_regulation TLR7 NOD2 21750585 1918457 Negative_regulation TLR7 NOD2 22114704 2573535 Negative_regulation TLR7 NOD2 22737610 2161100 Negative_regulation TLR7 NOD2 24459463 910844 Negative_regulation TLR7 NOD2 25423082 3029831 Negative_regulation TLR7 NOD2 25423082 3029867 Negative_regulation TLR7 NOX1 20532218 3047241 Negative_regulation TLR7 NOX4 20532218 3047242 Negative_regulation TLR7 PAF1 20976181 2479204 Negative_regulation TLR7 PARP1 25118589 1944015 Negative_regulation TLR7 PDCD4 23078795 1617453 Negative_regulation TLR7 PIK3CA 20953381 1748430 Negative_regulation TLR7 PIK3CA 20953381 1748431 Negative_regulation TLR7 PIK3CA 21738617 2532858 Negative_regulation TLR7 PIK3CA 21738617 2532986 Negative_regulation TLR7 PIK3CA 22606294 2642968 Negative_regulation TLR7 PIK3CA 22737610 2161101 Negative_regulation TLR7 PIK3R1 20953381 1748432 Negative_regulation TLR7 PIK3R1 20953381 1748433 Negative_regulation TLR7 PIK3R1 21738617 2532859 Negative_regulation TLR7 PIK3R1 21738617 2532987 Negative_regulation TLR7 PIK3R1 22606294 2642969 Negative_regulation TLR7 PIK3R1 22737610 2161102 Negative_regulation TLR7 PIKFYVE 24040108 2845720 Negative_regulation TLR7 PIN1 21743479 1955520 Negative_regulation TLR7 PIN1 21743479 1955521 Negative_regulation TLR7 PKD1 22783258 902435 Negative_regulation TLR7 PLK1 24205328 2876005 Negative_regulation TLR7 POT1 25118589 1944862 Negative_regulation TLR7 PPARG 23559004 560956 Negative_regulation TLR7 PRKACB 18404494 3089333 Negative_regulation TLR7 PRKACG 18404494 3089334 Negative_regulation TLR7 PRKAR1A 18404494 3089335 Negative_regulation TLR7 PRKAR1B 18404494 3089336 Negative_regulation TLR7 PRKAR2A 18404494 3089337 Negative_regulation TLR7 PRKAR2B 18404494 3089338 Negative_regulation TLR7 PTPN6 20886024 1748352 Negative_regulation TLR7 RAC1 21098092 1561761 Negative_regulation TLR7 RAC2 21098092 1561762 Negative_regulation TLR7 RAC3 21098092 1561763 Negative_regulation TLR7 RAD50 25118589 1944018 Negative_regulation TLR7 RAD50 25118589 1944865 Negative_regulation TLR7 RASGRP1 25118589 1943900 Negative_regulation TLR7 RASGRP3 25118589 1944013 Negative_regulation TLR7 RELA 23506673 1036620 Negative_regulation TLR7 RICTOR 24740015 2954420 Negative_regulation TLR7 RNF216 20886024 1748350 Negative_regulation TLR7 SIGIRR 21544241 2517366 Negative_regulation TLR7 SIGIRR 21544241 2517376 Negative_regulation TLR7 SIGIRR 21639951 122822 Negative_regulation TLR7 SIGIRR 22661952 957265 Negative_regulation TLR7 SIGIRR 22973499 1764550 Negative_regulation TLR7 SIGLEC1 25187624 760593 Negative_regulation TLR7 SIGLEC1 25187624 760594 Negative_regulation TLR7 SIGLEC10 25187624 760597 Negative_regulation TLR7 SIGLEC10 25187624 760598 Negative_regulation TLR7 SIGLEC11 25187624 760599 Negative_regulation TLR7 SIGLEC11 25187624 760600 Negative_regulation TLR7 SIGLEC12 25187624 760595 Negative_regulation TLR7 SIGLEC12 25187624 760596 Negative_regulation TLR7 SIGLEC14 25187624 760605 Negative_regulation TLR7 SIGLEC14 25187624 760606 Negative_regulation TLR7 SIGLEC15 25187624 760603 Negative_regulation TLR7 SIGLEC15 25187624 760604 Negative_regulation TLR7 SIGLEC16 25187624 760601 Negative_regulation TLR7 SIGLEC16 25187624 760602 Negative_regulation TLR7 SIGLEC5 25187624 760583 Negative_regulation TLR7 SIGLEC5 25187624 760584 Negative_regulation TLR7 SIGLEC6 25187624 760585 Negative_regulation TLR7 SIGLEC6 25187624 760586 Negative_regulation TLR7 SIGLEC7 25187624 760587 Negative_regulation TLR7 SIGLEC7 25187624 760588 Negative_regulation TLR7 SIGLEC8 25187624 760589 Negative_regulation TLR7 SIGLEC8 25187624 760590 Negative_regulation TLR7 SIGLEC9 25187624 760591 Negative_regulation TLR7 SIGLEC9 25187624 760592 Negative_regulation TLR7 SOCS1 20862390 979445 Negative_regulation TLR7 SOCS1 20862390 979446 Negative_regulation TLR7 SOCS1 20862390 979634 Negative_regulation TLR7 SOCS1 22566904 899816 Negative_regulation TLR7 SOCS1 24069550 1706644 Negative_regulation TLR7 SOCS2 19779605 2427222 Negative_regulation TLR7 SOCS2 24489947 2917068 Negative_regulation TLR7 SOCS3 24069550 1706645 Negative_regulation TLR7 ST2 22661952 957263 Negative_regulation TLR7 ST2 23483993 2764975 Negative_regulation TLR7 SYK 24286216 130789 Negative_regulation TLR7 SYK 24286216 130821 Negative_regulation TLR7 TAB2 22661952 957264 Negative_regulation TLR7 TAB2 23799152 2807220 Negative_regulation TLR7 TANK 18411340 1550410 Negative_regulation TLR7 TBK1 22945920 1569292 Negative_regulation TLR7 TDGF1P3 22586164 91019 Negative_regulation TLR7 TERF1 25118589 1944859 Negative_regulation TLR7 TERF2 25118589 1944011 Negative_regulation TLR7 TERF2 25118589 1944860 Negative_regulation TLR7 TERF2IP 25118589 1944014 Negative_regulation TLR7 TERF2IP 25118589 1944863 Negative_regulation TLR7 TINF2 25118589 1944861 Negative_regulation TLR7 TLR2 19088911 2214829 Negative_regulation TLR7 TLR8 24904837 865217 Negative_regulation TLR7 TLR9 19325820 1087890 Negative_regulation TLR7 TLR9 24904837 865218 Negative_regulation TLR7 TMEM100 23429360 835963 Negative_regulation TLR7 TMEM101 23429360 836029 Negative_regulation TLR7 TMEM102 23429360 835992 Negative_regulation TLR7 TMEM104 23429360 835972 Negative_regulation TLR7 TMEM105 23429360 835994 Negative_regulation TLR7 TMEM107 23429360 836009 Negative_regulation TLR7 TMEM108 23429360 836022 Negative_regulation TLR7 TMEM109 23429360 836031 Negative_regulation TLR7 TMEM11 23429360 835915 Negative_regulation TLR7 TMEM110 23429360 836043 Negative_regulation TLR7 TMEM114 23429360 836057 Negative_regulation TLR7 TMEM115 23429360 836037 Negative_regulation TLR7 TMEM116 23429360 835943 Negative_regulation TLR7 TMEM117 23429360 835951 Negative_regulation TLR7 TMEM119 23429360 836003 Negative_regulation TLR7 TMEM121 23429360 835925 Negative_regulation TLR7 TMEM123 23429360 836039 Negative_regulation TLR7 TMEM125 23429360 836017 Negative_regulation TLR7 TMEM127 23429360 835973 Negative_regulation TLR7 TMEM128 23429360 836014 Negative_regulation TLR7 TMEM129 23429360 835946 Negative_regulation TLR7 TMEM130 23429360 835954 Negative_regulation TLR7 TMEM131 23429360 836041 Negative_regulation TLR7 TMEM133 23429360 835937 Negative_regulation TLR7 TMEM134 23429360 835976 Negative_regulation TLR7 TMEM135 23429360 835977 Negative_regulation TLR7 TMEM136 23429360 836018 Negative_regulation TLR7 TMEM138 23429360 835996 Negative_regulation TLR7 TMEM139 23429360 835934 Negative_regulation TLR7 TMEM140 23429360 835931 Negative_regulation TLR7 TMEM141 23429360 836015 Negative_regulation TLR7 TMEM143 23429360 835961 Negative_regulation TLR7 TMEM144 23429360 835966 Negative_regulation TLR7 TMEM145 23429360 835995 Negative_regulation TLR7 TMEM147 23429360 836042 Negative_regulation TLR7 TMEM154 23429360 835987 Negative_regulation TLR7 TMEM155 23429360 835985 Negative_regulation TLR7 TMEM156 23429360 835981 Negative_regulation TLR7 TMEM158 23429360 836040 Negative_regulation TLR7 TMEM159 23429360 836038 Negative_regulation TLR7 TMEM160 23429360 835974 Negative_regulation TLR7 TMEM163 23429360 835953 Negative_regulation TLR7 TMEM164 23429360 835980 Negative_regulation TLR7 TMEM165 23429360 836045 Negative_regulation TLR7 TMEM168 23429360 835968 Negative_regulation TLR7 TMEM169 23429360 835945 Negative_regulation TLR7 TMEM17 23429360 835991 Negative_regulation TLR7 TMEM171 23429360 835997 Negative_regulation TLR7 TMEM173 23429360 836006 Negative_regulation TLR7 TMEM174 23429360 836012 Negative_regulation TLR7 TMEM175 23429360 836030 Negative_regulation TLR7 TMEM177 23429360 836010 Negative_regulation TLR7 TMEM179 23429360 835922 Negative_regulation TLR7 TMEM18 23429360 835950 Negative_regulation TLR7 TMEM180 23429360 835979 Negative_regulation TLR7 TMEM181 23429360 835926 Negative_regulation TLR7 TMEM182 23429360 835983 Negative_regulation TLR7 TMEM186 23429360 835940 Negative_regulation TLR7 TMEM187 23429360 835910 Negative_regulation TLR7 TMEM189 23429360 835914 Negative_regulation TLR7 TMEM19 23429360 835962 Negative_regulation TLR7 TMEM190 23429360 836036 Negative_regulation TLR7 TMEM192 23429360 835993 Negative_regulation TLR7 TMEM196 23429360 835935 Negative_regulation TLR7 TMEM198 23429360 836058 Negative_regulation TLR7 TMEM199 23429360 835918 Negative_regulation TLR7 TMEM2 23429360 835906 Negative_regulation TLR7 TMEM201 23429360 836060 Negative_regulation TLR7 TMEM202 23429360 836062 Negative_regulation TLR7 TMEM203 23429360 836016 Negative_regulation TLR7 TMEM204 23429360 835911 Negative_regulation TLR7 TMEM205 23429360 836035 Negative_regulation TLR7 TMEM206 23429360 835960 Negative_regulation TLR7 TMEM207 23429360 836059 Negative_regulation TLR7 TMEM208 23429360 835941 Negative_regulation TLR7 TMEM209 23429360 835932 Negative_regulation TLR7 TMEM210 23429360 836065 Negative_regulation TLR7 TMEM211 23429360 836061 Negative_regulation TLR7 TMEM212 23429360 836066 Negative_regulation TLR7 TMEM213 23429360 835998 Negative_regulation TLR7 TMEM214 23429360 835971 Negative_regulation TLR7 TMEM215 23429360 836064 Negative_regulation TLR7 TMEM216 23429360 835942 Negative_regulation TLR7 TMEM217 23429360 835927 Negative_regulation TLR7 TMEM218 23429360 836000 Negative_regulation TLR7 TMEM219 23429360 835948 Negative_regulation TLR7 TMEM220 23429360 836063 Negative_regulation TLR7 TMEM221 23429360 835933 Negative_regulation TLR7 TMEM222 23429360 835952 Negative_regulation TLR7 TMEM223 23429360 836023 Negative_regulation TLR7 TMEM225 23429360 836054 Negative_regulation TLR7 TMEM230 23429360 835913 Negative_regulation TLR7 TMEM231 23429360 836068 Negative_regulation TLR7 TMEM232 23429360 836069 Negative_regulation TLR7 TMEM233 23429360 836067 Negative_regulation TLR7 TMEM234 23429360 836033 Negative_regulation TLR7 TMEM235 23429360 836002 Negative_regulation TLR7 TMEM236 23429360 835936 Negative_regulation TLR7 TMEM237 23429360 835912 Negative_regulation TLR7 TMEM238 23429360 836070 Negative_regulation TLR7 TMEM239 23429360 836071 Negative_regulation TLR7 TMEM240 23429360 835947 Negative_regulation TLR7 TMEM241 23429360 836047 Negative_regulation TLR7 TMEM242 23429360 835917 Negative_regulation TLR7 TMEM243 23429360 835929 Negative_regulation TLR7 TMEM244 23429360 835928 Negative_regulation TLR7 TMEM245 23429360 835909 Negative_regulation TLR7 TMEM246 23429360 836011 Negative_regulation TLR7 TMEM247 23429360 836072 Negative_regulation TLR7 TMEM248 23429360 835956 Negative_regulation TLR7 TMEM249 23429360 836073 Negative_regulation TLR7 TMEM25 23429360 835970 Negative_regulation TLR7 TMEM251 23429360 835924 Negative_regulation TLR7 TMEM252 23429360 836025 Negative_regulation TLR7 TMEM253 23429360 836056 Negative_regulation TLR7 TMEM254 23429360 835967 Negative_regulation TLR7 TMEM256 23429360 836028 Negative_regulation TLR7 TMEM257 23429360 835964 Negative_regulation TLR7 TMEM258 23429360 835905 Negative_regulation TLR7 TMEM259 23429360 835916 Negative_regulation TLR7 TMEM26 23429360 836026 Negative_regulation TLR7 TMEM260 23429360 835923 Negative_regulation TLR7 TMEM261 23429360 836044 Negative_regulation TLR7 TMEM27 23429360 836034 Negative_regulation TLR7 TMEM31 23429360 836027 Negative_regulation TLR7 TMEM33 23429360 835958 Negative_regulation TLR7 TMEM35 23429360 835969 Negative_regulation TLR7 TMEM37 23429360 835919 Negative_regulation TLR7 TMEM40 23429360 835965 Negative_regulation TLR7 TMEM42 23429360 836021 Negative_regulation TLR7 TMEM43 23429360 836024 Negative_regulation TLR7 TMEM44 23429360 835944 Negative_regulation TLR7 TMEM47 23429360 835920 Negative_regulation TLR7 TMEM5 23429360 835908 Negative_regulation TLR7 TMEM51 23429360 835957 Negative_regulation TLR7 TMEM52 23429360 836005 Negative_regulation TLR7 TMEM53 23429360 835978 Negative_regulation TLR7 TMEM54 23429360 835938 Negative_regulation TLR7 TMEM56 23429360 835986 Negative_regulation TLR7 TMEM57 23429360 835959 Negative_regulation TLR7 TMEM59 23429360 835907 Negative_regulation TLR7 TMEM60 23429360 835930 Negative_regulation TLR7 TMEM61 23429360 835999 Negative_regulation TLR7 TMEM62 23429360 835982 Negative_regulation TLR7 TMEM64 23429360 835955 Negative_regulation TLR7 TMEM65 23429360 835949 Negative_regulation TLR7 TMEM66 23429360 836032 Negative_regulation TLR7 TMEM67 23429360 836020 Negative_regulation TLR7 TMEM68 23429360 835988 Negative_regulation TLR7 TMEM69 23429360 836007 Negative_regulation TLR7 TMEM70 23429360 835975 Negative_regulation TLR7 TMEM71 23429360 835989 Negative_regulation TLR7 TMEM72 23429360 836046 Negative_regulation TLR7 TMEM74 23429360 835984 Negative_regulation TLR7 TMEM75 23429360 836048 Negative_regulation TLR7 TMEM78 23429360 836049 Negative_regulation TLR7 TMEM79 23429360 836013 Negative_regulation TLR7 TMEM80 23429360 836001 Negative_regulation TLR7 TMEM81 23429360 836050 Negative_regulation TLR7 TMEM82 23429360 836051 Negative_regulation TLR7 TMEM88 23429360 836052 Negative_regulation TLR7 TMEM89 23429360 836053 Negative_regulation TLR7 TMEM9 23429360 835921 Negative_regulation TLR7 TMEM91 23429360 836055 Negative_regulation TLR7 TMEM92 23429360 835990 Negative_regulation TLR7 TMEM95 23429360 836004 Negative_regulation TLR7 TMEM97 23429360 836008 Negative_regulation TLR7 TMEM98 23429360 835939 Negative_regulation TLR7 TMEM99 23429360 836019 Negative_regulation TLR7 TNF 23497095 2236060 Negative_regulation TLR7 TNFAIP3 18268035 1549236 Negative_regulation TLR7 TNFAIP3 20886024 1748349 Negative_regulation TLR7 TNIP1 23358229 2744769 Negative_regulation TLR7 TNIP2 23358229 2744770 Negative_regulation TLR7 TNIP3 23358229 2744771 Negative_regulation TLR7 TOLLIP 17615075 320479 Negative_regulation TLR7 TOLLIP 24459463 910843 Negative_regulation TLR7 TOLLIP 25101079 913626 Negative_regulation TLR7 TOLLIP 25478190 412943 Negative_regulation TLR7 TP53 21483755 2323100 Negative_regulation TLR7 TRAF3 23758787 1649489 Negative_regulation TLR7 TRAF6 18411340 1550411 Negative_regulation TLR7 TRAF6 20497537 362644 Negative_regulation TLR7 TRAF6 21188194 139519 Negative_regulation TLR7 TRAF6 21964925 600374 Negative_regulation TLR7 TRAF6 22992343 1866836 Negative_regulation TLR7 TRAF6 23799152 2807217 Negative_regulation TLR7 TRAM1 23078795 1617284 Negative_regulation TLR7 TRAM2 23078795 1617283 Negative_regulation TLR7 TRIM21 22479513 2615636 Negative_regulation TLR7 TRIM68 24999993 2986726 Negative_regulation TLR7 UBE2V1 23799152 2807218 Negative_regulation TLR7 UNC93B1 17452530 1339451 Negative_regulation TLR7 UNC93B1 17452530 1339740 Negative_regulation TLR7 UNC93B2 17452530 1339452 Negative_regulation TLR7 UNC93B2 17452530 1339741 Negative_regulation TLR7 UNC93B3 17452530 1339453 Negative_regulation TLR7 UNC93B3 17452530 1339742 Negative_regulation TLR7 UNC93B4 17452530 1339454 Negative_regulation TLR7 UNC93B4 17452530 1339743 Negative_regulation TLR7 UNC93B5 17452530 1339455 Negative_regulation TLR7 UNC93B5 17452530 1339744 Negative_regulation TLR7 UNC93B6 17452530 1339456 Negative_regulation TLR7 UNC93B6 17452530 1339745 Negative_regulation TLR7 UNC93B7 17452530 1339457 Negative_regulation TLR7 UNC93B7 17452530 1339746 Negative_regulation TLR7 UNC93B8 17452530 1339458 Negative_regulation TLR7 UNC93B8 17452530 1339747 Negative_regulation TLR7 USP2 23429360 838623 Negative_regulation TLR7 USP7 20454685 2449683 Negative_regulation TLR7 WDR61 20976181 2479205 Negative_regulation TLR7 WWP1 23799152 2807219 Negative_regulation TLR7 XRCC5 25118589 1944012 Negative_regulation TLR7 XRCC6 25118589 1944016 Negative_regulation TLR8 CD14 21789185 2537939 Negative_regulation TLR8 MMP28 18762577 1356123 Negative_regulation TLR8 MMP7 18762577 1356138 Negative_regulation TLR8 TMEM100 23429360 836132 Negative_regulation TLR8 TMEM156 23429360 836150 Negative_regulation TLR8 TMEM211 23429360 836230 Negative_regulation TLR8 TMEM213 23429360 836167 Negative_regulation TLR8 TNF 23497095 2236061 Negative_regulation TLR9 ADRB2 23724117 2799025 Negative_regulation TLR9 CD14 21789185 2537940 Negative_regulation TLR9 MMP28 18762577 1356145 Negative_regulation TLR9 MMP28 24959259 2168926 Negative_regulation TLR9 MMP7 18762577 1356160 Negative_regulation TLR9 MMP7 24959259 2168941 Negative_regulation TLR9 TLR7 22826712 902574 Negative_regulation TLR9 TLR7 23189270 863865 Negative_regulation TLR9 TLR7 24904837 865219 Negative_regulation TLR9 TMEM100 23429360 836301 Negative_regulation TLR9 TMEM156 23429360 836319 Negative_regulation TLR9 TMEM211 23429360 836399 Negative_regulation TLR9 TMEM213 23429360 836336 Negative_regulation TLR9 TNF 15631627 3104189 Negative_regulation TLR9 TNF 23497095 2236062 Negative_regulation TLR9 TNF 23752229 1572496 Negative_regulation TMED7 CCND1 10424746 415062 Negative_regulation TMED7 CCND1 16595007 3083286 Negative_regulation TMED7 CCND1 20642839 1647228 Negative_regulation TMED7 CCND1 20865053 2475148 Negative_regulation TMED7 CCND1 21179458 2488084 Negative_regulation TMED7 CCND1 21209944 2492503 Negative_regulation TMED7 CCND1 21909380 2551683 Negative_regulation TMED7 CCND1 24004818 1618320 Negative_regulation TMED7 CCND1 25202365 2169627 Negative_regulation TMED7 EGLN3 22087251 2570783 Negative_regulation TMED7 EPHB2 17663798 320714 Negative_regulation TMED7 EPHB2 19015320 1361413 Negative_regulation TMED7 IFI27 14734530 1304593 Negative_regulation TMED7 IFI27 20200561 1719455 Negative_regulation TMED7 IFI27 23801714 727615 Negative_regulation TMED7 IL1B 12928151 791900 Negative_regulation TMED7 MMP28 23785669 945494 Negative_regulation TMED7 MMP28 24690323 540140 Negative_regulation TMED7 MMP7 23785669 945509 Negative_regulation TMED7 MMP7 24690323 540155 Negative_regulation TMED7 SCGB3A1 PMC4233555 477216 Negative_regulation TMED7 UCA1 24457952 571303 Negative_regulation TMEM100 BST2 22163340 3220726 Negative_regulation TMEM100 CPB1 25489576 1235712 Negative_regulation TMEM100 CPB1 25489576 1236161 Negative_regulation TMEM100 CPB2 25489576 1235713 Negative_regulation TMEM100 CPB2 25489576 1236162 Negative_regulation TMEM100 ERBB2 21443808 397578 Negative_regulation TMEM100 IL2 24344781 364362 Negative_regulation TMEM100 IL4 24344781 364363 Negative_regulation TMEM100 PTCH1 21394208 2506630 Negative_regulation TMEM100 PTCH1 22025972 85723 Negative_regulation TMEM100 SHH 23351793 628283 Negative_regulation TMEM156 BST2 22163340 3220744 Negative_regulation TMEM156 CPB1 25489576 1235748 Negative_regulation TMEM156 CPB1 25489576 1236197 Negative_regulation TMEM156 CPB2 25489576 1235749 Negative_regulation TMEM156 CPB2 25489576 1236198 Negative_regulation TMEM156 ERBB2 21443808 397596 Negative_regulation TMEM156 IL2 24344781 364398 Negative_regulation TMEM156 IL4 24344781 364399 Negative_regulation TMEM156 PTCH1 21394208 2506648 Negative_regulation TMEM156 PTCH1 22025972 85741 Negative_regulation TMEM156 SHH 23351793 628301 Negative_regulation TMEM211 BST2 22163340 3220824 Negative_regulation TMEM211 CPB1 25489576 1235908 Negative_regulation TMEM211 CPB1 25489576 1236357 Negative_regulation TMEM211 CPB2 25489576 1235909 Negative_regulation TMEM211 CPB2 25489576 1236358 Negative_regulation TMEM211 ERBB2 21443808 397676 Negative_regulation TMEM211 IL2 24344781 364558 Negative_regulation TMEM211 IL4 24344781 364559 Negative_regulation TMEM211 PTCH1 21394208 2506728 Negative_regulation TMEM211 PTCH1 22025972 85821 Negative_regulation TMEM211 SHH 23351793 628381 Negative_regulation TMEM213 BST2 22163340 3220761 Negative_regulation TMEM213 CPB1 25489576 1235782 Negative_regulation TMEM213 CPB1 25489576 1236231 Negative_regulation TMEM213 CPB2 25489576 1235783 Negative_regulation TMEM213 CPB2 25489576 1236232 Negative_regulation TMEM213 ERBB2 21443808 397613 Negative_regulation TMEM213 IL2 24344781 364432 Negative_regulation TMEM213 IL4 24344781 364433 Negative_regulation TMEM213 PTCH1 21394208 2506665 Negative_regulation TMEM213 PTCH1 22025972 85758 Negative_regulation TMEM213 SHH 23351793 628318 Negative_regulation TMOD1 NEB 20498015 1376445 Negative_regulation TMOD1 NEB 22013379 1222793 Negative_regulation TMOD1 NEUROD1 23638401 2236504 Negative_regulation TMOD1 NEUROD2 23638401 2236505 Negative_regulation TMOD1 NEUROD4 23638401 2236502 Negative_regulation TMOD1 NEUROD6 23638401 2236503 Negative_regulation TMOD1 TMOD2 23638401 2236501 Negative_regulation TMOD1 TPM1 8163552 1445356 Negative_regulation TMOD1 TPM1 8408215 1448230 Negative_regulation TMOD1 TPM2 8163552 1445357 Negative_regulation TMOD1 TPM2 8408215 1448231 Negative_regulation TMOD1 TPM3 8163552 1445358 Negative_regulation TMOD1 TPM3 8408215 1448232 Negative_regulation TMOD1 TPM4 8163552 1445359 Negative_regulation TMOD1 TPM4 8408215 1448233 Negative_regulation TMOD1 TRIM32 22908310 1399541 Negative_regulation TMPRSS2 CCND1 19079343 2124207 Negative_regulation TMPRSS4 CDH1 24748857 1021861 Negative_regulation TMPRSS4 KAT5 23821596 992833 Negative_regulation TNF AATF 22933572 1807246 Negative_regulation TNF ABCC6 24603865 2932587 Negative_regulation TNF ACE2 22518292 1080012 Negative_regulation TNF ACE2 25152758 826755 Negative_regulation TNF ACSM3 20731855 659656 Negative_regulation TNF ACTL6A 24330807 1667463 Negative_regulation TNF ADA 22192852 124468 Negative_regulation TNF ADA 22864384 1727455 Negative_regulation TNF ADAM17 22319556 2595426 Negative_regulation TNF ADAM17 22319556 2595427 Negative_regulation TNF ADAM17 22319556 2595429 Negative_regulation TNF ADAM17 22319556 2595433 Negative_regulation TNF ADAM17 22319556 2595434 Negative_regulation TNF ADAM17 22389670 2607907 Negative_regulation TNF ADAM17 23251384 2728482 Negative_regulation TNF ADAM17 23341882 2741319 Negative_regulation TNF ADAM17 23979021 611334 Negative_regulation TNF ADAM17 24223177 2876613 Negative_regulation TNF ADAM17 25414771 206652 Negative_regulation TNF ADAMTS1 18387286 1731641 Negative_regulation TNF ADCY1 20068138 712630 Negative_regulation TNF ADCY10 20068138 712629 Negative_regulation TNF ADCY2 20068138 712631 Negative_regulation TNF ADCY3 20068138 712632 Negative_regulation TNF ADCY4 20068138 712633 Negative_regulation TNF ADCY5 20068138 712634 Negative_regulation TNF ADCY6 20068138 712635 Negative_regulation TNF ADCY7 20068138 712636 Negative_regulation TNF ADCY8 20068138 712637 Negative_regulation TNF ADCY9 20068138 712638 Negative_regulation TNF ADCYAP1 24856828 222934 Negative_regulation TNF ADIPOQ 20825686 400962 Negative_regulation TNF ADIPOQ 20840785 3213288 Negative_regulation TNF ADIPOQ 21143922 3111751 Negative_regulation TNF ADIPOQ 21352586 1723455 Negative_regulation TNF ADIPOQ 21586104 659901 Negative_regulation TNF ADIPOQ 21941676 1082278 Negative_regulation TNF ADIPOQ 21988829 1723920 Negative_regulation TNF ADIPOQ 22007173 950484 Negative_regulation TNF ADIPOQ 22272381 1082507 Negative_regulation TNF ADIPOQ 22347618 2116156 Negative_regulation TNF ADIPOQ 22701235 1047559 Negative_regulation TNF ADIPOQ 22848362 2668538 Negative_regulation TNF ADIPOQ 22969168 1750374 Negative_regulation TNF ADIPOQ 23275933 730653 Negative_regulation TNF ADIPOQ 23533302 1751749 Negative_regulation TNF ADIPOQ 23675368 878472 Negative_regulation TNF ADIPOQ 23781214 878818 Negative_regulation TNF ADIPOQ 23908975 649288 Negative_regulation TNF ADIPOQ 24369466 1073872 Negative_regulation TNF ADIPOQ 24455420 1152546 Negative_regulation TNF ADIPOQ 24455420 1152547 Negative_regulation TNF ADIPOQ 24466027 2912125 Negative_regulation TNF ADIPOQ 24744899 2251819 Negative_regulation TNF ADIPOQ 24936137 1085247 Negative_regulation TNF ADIPOQ 25566464 1498524 Negative_regulation TNF ADM 22859951 2670544 Negative_regulation TNF ADM 24348533 980714 Negative_regulation TNF ADM 24348533 980732 Negative_regulation TNF ADO 23897810 1207978 Negative_regulation TNF ADRB2 23724117 2799033 Negative_regulation TNF AGA 21317295 717810 Negative_regulation TNF AGTR1 21884646 659993 Negative_regulation TNF AGTR2 18500976 3108952 Negative_regulation TNF AHR 19707336 175515 Negative_regulation TNF AHR 21298084 2320978 Negative_regulation TNF AHR 21298084 2321018 Negative_regulation TNF AHR 24527450 186982 Negative_regulation TNF AHR 24527450 186998 Negative_regulation TNF AHR 25201625 541036 Negative_regulation TNF AHSA1 20644716 2455935 Negative_regulation TNF AHSA1 21314908 3209828 Negative_regulation TNF AHSA1 23549267 1104729 Negative_regulation TNF AHSA1 23549267 1104730 Negative_regulation TNF AHSA1 24386004 825046 Negative_regulation TNF AHSA1 25210730 3006613 Negative_regulation TNF AHSG 21418657 357042 Negative_regulation TNF AHSG 21747711 1091341 Negative_regulation TNF AKAP13 19277197 2407714 Negative_regulation TNF AKT1 22606294 2643001 Negative_regulation TNF AKT1 22606294 2643011 Negative_regulation TNF AKT1 22606294 2643014 Negative_regulation TNF AKT1 24206648 367411 Negative_regulation TNF AKT1 24206648 367422 Negative_regulation TNF AKT1 24516119 1574934 Negative_regulation TNF AKT1 24669186 742958 Negative_regulation TNF AKT1 24945834 2981612 Negative_regulation TNF AKT2 22606294 2643002 Negative_regulation TNF AKT2 22606294 2643012 Negative_regulation TNF AKT2 22606294 2643015 Negative_regulation TNF AKT2 24516119 1574935 Negative_regulation TNF AKT2 24669186 742959 Negative_regulation TNF AKT2 24945834 2981613 Negative_regulation TNF AKT3 22606294 2643003 Negative_regulation TNF AKT3 22606294 2643013 Negative_regulation TNF AKT3 22606294 2643016 Negative_regulation TNF AKT3 24516119 1574936 Negative_regulation TNF AKT3 24669186 742960 Negative_regulation TNF AKT3 24945834 2981614 Negative_regulation TNF ALB 21317295 717930 Negative_regulation TNF ANPEP 21912612 2552215 Negative_regulation TNF ANPEP 23762489 2803703 Negative_regulation TNF ANXA1 22011168 354795 Negative_regulation TNF ANXA6 22039070 1795990 Negative_regulation TNF AP5B1 23094196 1082716 Negative_regulation TNF APC 16168069 658593 Negative_regulation TNF APC 17101035 658795 Negative_regulation TNF APC 19774207 175893 Negative_regulation TNF APC 20398279 659533 Negative_regulation TNF APC 22645700 1082570 Negative_regulation TNF APC 9053444 1600140 Negative_regulation TNF APOA1 12110136 99153 Negative_regulation TNF APOA1 17162363 630503 Negative_regulation TNF APOB 20846396 353591 Negative_regulation TNF APOB 20946675 1723327 Negative_regulation TNF APOB 22956783 1637605 Negative_regulation TNF APOB 8920850 1599299 Negative_regulation TNF APOE 20182542 1213835 Negative_regulation TNF APOE 20613949 631916 Negative_regulation TNF APOE 21772670 1749346 Negative_regulation TNF APOE 24948358 1668260 Negative_regulation TNF ARG1 20811626 2473302 Negative_regulation TNF ARG1 22272040 1694257 Negative_regulation TNF ARG1 23577028 1674544 Negative_regulation TNF ARG2 20811626 2473303 Negative_regulation TNF ARID1A 24330807 1667462 Negative_regulation TNF ARSA 21196646 3129467 Negative_regulation TNF ARSA 22412841 2609335 Negative_regulation TNF ARSA 24553063 2118522 Negative_regulation TNF ASL 20052267 2370615 Negative_regulation TNF ASL 20052267 2370616 Negative_regulation TNF ATF2 21429205 626976 Negative_regulation TNF ATF3 24062788 822838 Negative_regulation TNF ATL1 21831303 1659166 Negative_regulation TNF ATL1 21831303 1659167 Negative_regulation TNF ATL1 21831303 1659168 Negative_regulation TNF ATL1 21831303 1659169 Negative_regulation TNF ATL1 21831303 1659170 Negative_regulation TNF ATL1 21831303 1659359 Negative_regulation TNF ATL1 21831303 1659360 Negative_regulation TNF ATL1 21831303 1659374 Negative_regulation TNF ATL1 21831303 1659393 Negative_regulation TNF ATL1 23555007 2774334 Negative_regulation TNF ATL2 21831303 1659171 Negative_regulation TNF ATL2 21831303 1659172 Negative_regulation TNF ATL2 21831303 1659173 Negative_regulation TNF ATL2 21831303 1659174 Negative_regulation TNF ATL2 21831303 1659175 Negative_regulation TNF ATL2 21831303 1659361 Negative_regulation TNF ATL2 21831303 1659362 Negative_regulation TNF ATL2 21831303 1659375 Negative_regulation TNF ATL2 21831303 1659394 Negative_regulation TNF ATL2 23555007 2774335 Negative_regulation TNF ATL3 21831303 1659176 Negative_regulation TNF ATL3 21831303 1659177 Negative_regulation TNF ATL3 21831303 1659178 Negative_regulation TNF ATL3 21831303 1659179 Negative_regulation TNF ATL3 21831303 1659180 Negative_regulation TNF ATL3 21831303 1659363 Negative_regulation TNF ATL3 21831303 1659364 Negative_regulation TNF ATL3 21831303 1659376 Negative_regulation TNF ATL3 21831303 1659395 Negative_regulation TNF ATL3 23555007 2774336 Negative_regulation TNF ATP5O 25073093 1128761 Negative_regulation TNF ATP8A2 17965763 810778 Negative_regulation TNF AVP 19440308 2416701 Negative_regulation TNF AXL 25344858 2205866 Negative_regulation TNF B2M 23418570 2754458 Negative_regulation TNF BAX 21966512 2559191 Negative_regulation TNF BCL10 9064324 1600225 Negative_regulation TNF BCL2 9064324 1600226 Negative_regulation TNF BCL3 24130828 2867264 Negative_regulation TNF BCL3 24130828 2867265 Negative_regulation TNF BCL3 24130828 2867270 Negative_regulation TNF BCL3 24130828 2867278 Negative_regulation TNF BCL3 24130828 2867279 Negative_regulation TNF BCL3 24130828 2867280 Negative_regulation TNF BCL3 24130828 2867283 Negative_regulation TNF BCL3 24416643 1707924 Negative_regulation TNF BCL3 24943108 356648 Negative_regulation TNF BDNF 21490702 1748858 Negative_regulation TNF BDNF 21490702 1748859 Negative_regulation TNF BDNF 21490702 1748865 Negative_regulation TNF BDNF 25184950 1129352 Negative_regulation TNF BMP2 24141610 453547 Negative_regulation TNF BPIFA1 24391738 2904304 Negative_regulation TNF BPNT1 19765281 117225 Negative_regulation TNF BRD1 22189182 1229998 Negative_regulation TNF BRD1 22189182 1229999 Negative_regulation TNF BST2 20485522 3046850 Negative_regulation TNF BTK 21611196 2523841 Negative_regulation TNF BTK 21611196 2523853 Negative_regulation TNF BTRC 9467064 797614 Negative_regulation TNF C1QTNF3 22837306 723977 Negative_regulation TNF C1QTNF3 23409033 2753304 Negative_regulation TNF C1QTNF3 24417980 510641 Negative_regulation TNF C4A 24789665 1886415 Negative_regulation TNF C5 2165128 1564026 Negative_regulation TNF C5 2165128 1564029 Negative_regulation TNF C5 23233853 905194 Negative_regulation TNF C5 24789665 1886416 Negative_regulation TNF C5AR1 23233853 905140 Negative_regulation TNF CA2 2536067 1577276 Negative_regulation TNF CALML3 25525303 1763342 Negative_regulation TNF CAMP 16503962 3106686 Negative_regulation TNF CAMP 24454930 2910394 Negative_regulation TNF CAPS 12426150 791468 Negative_regulation TNF CASP1 19997504 3045751 Negative_regulation TNF CASP1 21368763 1987166 Negative_regulation TNF CASP1 22075985 547592 Negative_regulation TNF CASP1 22848449 2669069 Negative_regulation TNF CASP1 23505386 2343636 Negative_regulation TNF CASP1 24577084 572472 Negative_regulation TNF CASP1 25268882 3011777 Negative_regulation TNF CASP1 9565639 1602743 Negative_regulation TNF CASP10 21368763 1987167 Negative_regulation TNF CASP10 22075985 547593 Negative_regulation TNF CASP10 22848449 2669070 Negative_regulation TNF CASP10 23505386 2343637 Negative_regulation TNF CASP10 24577084 572473 Negative_regulation TNF CASP10 25268882 3011778 Negative_regulation TNF CASP10 9565639 1602744 Negative_regulation TNF CASP12 21368763 1987177 Negative_regulation TNF CASP12 22075985 547603 Negative_regulation TNF CASP12 22848449 2669080 Negative_regulation TNF CASP12 23505386 2343647 Negative_regulation TNF CASP12 24577084 572483 Negative_regulation TNF CASP12 25268882 3011788 Negative_regulation TNF CASP12 9565639 1602754 Negative_regulation TNF CASP14 21368763 1987168 Negative_regulation TNF CASP14 22075985 547594 Negative_regulation TNF CASP14 22848449 2669071 Negative_regulation TNF CASP14 23505386 2343638 Negative_regulation TNF CASP14 24577084 572474 Negative_regulation TNF CASP14 25268882 3011779 Negative_regulation TNF CASP14 9565639 1602745 Negative_regulation TNF CASP16 21368763 1987178 Negative_regulation TNF CASP16 22075985 547604 Negative_regulation TNF CASP16 22848449 2669081 Negative_regulation TNF CASP16 23505386 2343648 Negative_regulation TNF CASP16 24577084 572484 Negative_regulation TNF CASP16 25268882 3011789 Negative_regulation TNF CASP16 9565639 1602755 Negative_regulation TNF CASP2 21368763 1987169 Negative_regulation TNF CASP2 22075985 547595 Negative_regulation TNF CASP2 22848449 2669072 Negative_regulation TNF CASP2 23505386 2343639 Negative_regulation TNF CASP2 24577084 572475 Negative_regulation TNF CASP2 25268882 3011780 Negative_regulation TNF CASP2 9565639 1602746 Negative_regulation TNF CASP3 19641635 1909326 Negative_regulation TNF CASP3 21368763 1987170 Negative_regulation TNF CASP3 22075985 547596 Negative_regulation TNF CASP3 22848449 2669073 Negative_regulation TNF CASP3 23505386 2343640 Negative_regulation TNF CASP3 24577084 572476 Negative_regulation TNF CASP3 25268882 3011781 Negative_regulation TNF CASP3 25552899 743678 Negative_regulation TNF CASP3 9565639 1602747 Negative_regulation TNF CASP4 21368763 1987171 Negative_regulation TNF CASP4 22075985 547597 Negative_regulation TNF CASP4 22848449 2669074 Negative_regulation TNF CASP4 23505386 2343641 Negative_regulation TNF CASP4 24577084 572477 Negative_regulation TNF CASP4 25268882 3011782 Negative_regulation TNF CASP4 9565639 1602748 Negative_regulation TNF CASP5 21368763 1987172 Negative_regulation TNF CASP5 22075985 547598 Negative_regulation TNF CASP5 22848449 2669075 Negative_regulation TNF CASP5 23505386 2343642 Negative_regulation TNF CASP5 24577084 572478 Negative_regulation TNF CASP5 25268882 3011783 Negative_regulation TNF CASP5 9565639 1602749 Negative_regulation TNF CASP6 21368763 1987173 Negative_regulation TNF CASP6 22075985 547599 Negative_regulation TNF CASP6 22848449 2669076 Negative_regulation TNF CASP6 23505386 2343643 Negative_regulation TNF CASP6 24577084 572479 Negative_regulation TNF CASP6 25268882 3011784 Negative_regulation TNF CASP6 9565639 1602750 Negative_regulation TNF CASP7 21368763 1987174 Negative_regulation TNF CASP7 22075985 547600 Negative_regulation TNF CASP7 22848449 2669077 Negative_regulation TNF CASP7 23505386 2343644 Negative_regulation TNF CASP7 24577084 572480 Negative_regulation TNF CASP7 25268882 3011785 Negative_regulation TNF CASP7 9565639 1602751 Negative_regulation TNF CASP8 19641635 1909327 Negative_regulation TNF CASP8 21368763 1987175 Negative_regulation TNF CASP8 22075985 547601 Negative_regulation TNF CASP8 22848449 2669078 Negative_regulation TNF CASP8 23505386 2343645 Negative_regulation TNF CASP8 24577084 572481 Negative_regulation TNF CASP8 25268882 3011786 Negative_regulation TNF CASP8 9565639 1602752 Negative_regulation TNF CASP9 21368763 1987176 Negative_regulation TNF CASP9 22075985 547602 Negative_regulation TNF CASP9 22848449 2669079 Negative_regulation TNF CASP9 23505386 2343646 Negative_regulation TNF CASP9 24577084 572482 Negative_regulation TNF CASP9 25268882 3011787 Negative_regulation TNF CASP9 9565639 1602753 Negative_regulation TNF CAT 18369465 3041033 Negative_regulation TNF CAT 19298665 3109371 Negative_regulation TNF CAT 19298665 3109372 Negative_regulation TNF CAT 22348221 1641572 Negative_regulation TNF CBR1 19476641 1897200 Negative_regulation TNF CBR1 19476641 1897223 Negative_regulation TNF CBR1 23818935 820659 Negative_regulation TNF CCK 22357963 721616 Negative_regulation TNF CCK 22357963 721617 Negative_regulation TNF CCK 22357963 721618 Negative_regulation TNF CCK 22357963 721620 Negative_regulation TNF CCK 24876883 825967 Negative_regulation TNF CCK PMC2213218 1605460 Negative_regulation TNF CCL19 19804625 117458 Negative_regulation TNF CCL2 18410682 110456 Negative_regulation TNF CCL2 19116667 2404024 Negative_regulation TNF CCL2 21752263 123229 Negative_regulation TNF CCL2 22069473 2569042 Negative_regulation TNF CCL2 23285282 2733423 Negative_regulation TNF CCL2 23663236 1666718 Negative_regulation TNF CCL2 24348712 824567 Negative_regulation TNF CCL3 17698589 1546795 Negative_regulation TNF CCNC 24741183 1047913 Negative_regulation TNF CCNG1 21283646 650488 Negative_regulation TNF CCNG1 23267358 905505 Negative_regulation TNF CCR7 19277197 2407713 Negative_regulation TNF CCR7 19277197 2407755 Negative_regulation TNF CCS 25375372 578808 Negative_regulation TNF CD14 12391013 1525085 Negative_regulation TNF CD14 17242961 810089 Negative_regulation TNF CD14 20419140 2447165 Negative_regulation TNF CD14 20946675 1723320 Negative_regulation TNF CD14 22194732 923853 Negative_regulation TNF CD14 22852877 532914 Negative_regulation TNF CD14 25332099 607540 Negative_regulation TNF CD14 7500012 1587102 Negative_regulation TNF CD2 25505551 1037372 Negative_regulation TNF CD274 18332181 1550113 Negative_regulation TNF CD274 21118528 659743 Negative_regulation TNF CD274 21418617 659874 Negative_regulation TNF CD274 24187568 639031 Negative_regulation TNF CD274 24324295 1755585 Negative_regulation TNF CD28 15833106 3104965 Negative_regulation TNF CD28 18670628 3041674 Negative_regulation TNF CD28 25041351 2251123 Negative_regulation TNF CD33 22500980 355773 Negative_regulation TNF CD33 22500980 355778 Negative_regulation TNF CD33 24391502 3065868 Negative_regulation TNF CD36 21949655 3053522 Negative_regulation TNF CD36 21949655 3053523 Negative_regulation TNF CD36 23734602 239841 Negative_regulation TNF CD3D 23803414 3121913 Negative_regulation TNF CD3E 23803414 3121914 Negative_regulation TNF CD3G 23803414 3121915 Negative_regulation TNF CD4 24936469 3167014 Negative_regulation TNF CD40 24155744 926295 Negative_regulation TNF CD40LG 24098562 2858173 Negative_regulation TNF CD44 15781582 1535038 Negative_regulation TNF CD44 15781582 1535092 Negative_regulation TNF CD44 25088370 1668372 Negative_regulation TNF CD46 22429752 660213 Negative_regulation TNF CD6 22340283 660182 Negative_regulation TNF CD6 22340283 660183 Negative_regulation TNF CD79A 20016738 2114378 Negative_regulation TNF CD79A 24648850 825384 Negative_regulation TNF CD86 22566973 900656 Negative_regulation TNF CDK19 24741183 1047918 Negative_regulation TNF CDK8 24741183 1047916 Negative_regulation TNF CEBPB 7530764 1589964 Negative_regulation TNF CFLAR 21307340 1786604 Negative_regulation TNF CFTR 21301926 1050341 Negative_regulation TNF CGA 25414772 206677 Negative_regulation TNF CHUK 20814569 2473438 Negative_regulation TNF CHUK 22046421 2567704 Negative_regulation TNF CHUK 25762184 1623427 Negative_regulation TNF CIDEA 17472743 656540 Negative_regulation TNF CIDEA 17472743 656543 Negative_regulation TNF CLDN3 25096552 2252349 Negative_regulation TNF CLEC4C 17850179 2263304 Negative_regulation TNF CLEC7A 16344862 3039082 Negative_regulation TNF CLEC7A 22235359 2371148 Negative_regulation TNF CLEC7A 22507600 313548 Negative_regulation TNF CLEC7A 23586068 181437 Negative_regulation TNF CLN3 23800945 1606789 Negative_regulation TNF CLN3 23800945 1606790 Negative_regulation TNF CLN3 23800945 1606804 Negative_regulation TNF CNR1 19305743 683311 Negative_regulation TNF CNR1 22204398 528173 Negative_regulation TNF CNR2 20098669 2437830 Negative_regulation TNF CNR2 22204398 528174 Negative_regulation TNF CNR2 22204398 528178 Negative_regulation TNF CNTN2 21345194 1504924 Negative_regulation TNF COG1 22408624 951340 Negative_regulation TNF COG2 22408624 951341 Negative_regulation TNF COG3 22408624 951335 Negative_regulation TNF COG4 22408624 951336 Negative_regulation TNF COG5 22408624 951334 Negative_regulation TNF COG6 22408624 951337 Negative_regulation TNF COG7 22408624 951338 Negative_regulation TNF COG8 22408624 951339 Negative_regulation TNF COL1A2 24088954 1709549 Negative_regulation TNF COQ2 20490320 1489916 Negative_regulation TNF COQ3 20490320 1489912 Negative_regulation TNF COQ4 20490320 1489913 Negative_regulation TNF COQ5 20490320 1489918 Negative_regulation TNF COQ6 20490320 1489914 Negative_regulation TNF COQ7 20490320 1489915 Negative_regulation TNF COQ9 20490320 1489917 Negative_regulation TNF CORO2A 23549795 3233070 Negative_regulation TNF CPB1 24386164 2902939 Negative_regulation TNF CPB2 24386164 2902940 Negative_regulation TNF CPN1 25253920 1762377 Negative_regulation TNF CPN1 25253920 1762385 Negative_regulation TNF CPOX 20862387 631930 Negative_regulation TNF CPOX 23035900 1231286 Negative_regulation TNF CPZ 2033366 1557961 Negative_regulation TNF CPZ 2033366 1557962 Negative_regulation TNF CPZ 2033366 1557964 Negative_regulation TNF CREB1 24225056 275969 Negative_regulation TNF CREB3 24225056 275970 Negative_regulation TNF CREB5 24225056 275968 Negative_regulation TNF CRH 25540945 1654247 Negative_regulation TNF CRISPLD2 23799041 2806718 Negative_regulation TNF CRK 15225374 101609 Negative_regulation TNF CRP 23407995 1050732 Negative_regulation TNF CRX 20803699 1050177 Negative_regulation TNF CSE 19515231 3109657 Negative_regulation TNF CSE 19515231 3109659 Negative_regulation TNF CSF1 1375270 1528745 Negative_regulation TNF CSF1 16356195 104874 Negative_regulation TNF CSF1R 20181277 118368 Negative_regulation TNF CSF1R 20181277 118372 Negative_regulation TNF CSF1R 20181277 118375 Negative_regulation TNF CSF2 18472950 1743274 Negative_regulation TNF CSF2 2165128 1564027 Negative_regulation TNF CSF2 22963460 1698825 Negative_regulation TNF CSF2 23586068 181380 Negative_regulation TNF CSF2 23586068 181418 Negative_regulation TNF CSF2 25387665 1050602 Negative_regulation TNF CSF3 18447905 356788 Negative_regulation TNF CSF3 18447905 356789 Negative_regulation TNF CSF3 18447905 356790 Negative_regulation TNF CSF3 22937076 2682811 Negative_regulation TNF CSF3 23209732 2722911 Negative_regulation TNF CSF3 25382983 1078361 Negative_regulation TNF CSK 24205328 2876001 Negative_regulation TNF CSK 24312681 2890707 Negative_regulation TNF CSN2 25006525 1152564 Negative_regulation TNF CSN3 25006525 1152563 Negative_regulation TNF CSPG4 18715114 2369401 Negative_regulation TNF CSPG5 18715114 2369402 Negative_regulation TNF CSRP1 21437087 731221 Negative_regulation TNF CSRP1 21686173 1091036 Negative_regulation TNF CSRP1 22778500 1750124 Negative_regulation TNF CSRP1 23407995 1050727 Negative_regulation TNF CTLA4 18534002 110954 Negative_regulation TNF CTLA4 19363483 1952342 Negative_regulation TNF CTLA4 19363483 1952365 Negative_regulation TNF CTLA4 24839355 1758667 Negative_regulation TNF CTNNBL1 19923857 2009225 Negative_regulation TNF CUL1 9467064 797615 Negative_regulation TNF CUX1 23805228 2807948 Negative_regulation TNF CX3CL1 22566871 899057 Negative_regulation TNF CX3CL1 22566871 899066 Negative_regulation TNF CX3CL1 22919540 1053556 Negative_regulation TNF CX3CR1 25152714 870968 Negative_regulation TNF CYLD 14676304 1530379 Negative_regulation TNF DAPK1 23880846 1108918 Negative_regulation TNF DCP2 18282094 3040854 Negative_regulation TNF DEFA1 23390582 3134167 Negative_regulation TNF DEFB103A 23390582 3134166 Negative_regulation TNF DEFB103B 20104491 808097 Negative_regulation TNF DEFB103B 20104491 808107 Negative_regulation TNF DEFB103B 20104491 808108 Negative_regulation TNF DEFB103B 20890434 1635293 Negative_regulation TNF DEFB103B 21809339 808390 Negative_regulation TNF DEFB103B 21809339 808391 Negative_regulation TNF DEFB103B 22389759 1675387 Negative_regulation TNF DEFB103B 22606066 3152812 Negative_regulation TNF DEFB103B 25187958 3004973 Negative_regulation TNF DHPS 20498849 2451124 Negative_regulation TNF DIABLO 21738708 2533446 Negative_regulation TNF DOCK3 21569552 1723635 Negative_regulation TNF DOCK3 21569552 1723637 Negative_regulation TNF DOK1 15699069 1534454 Negative_regulation TNF DOK1 15699069 1534492 Negative_regulation TNF DOK2 15699069 1534455 Negative_regulation TNF DOK2 15699069 1534493 Negative_regulation TNF DPP4 16277701 104850 Negative_regulation TNF DPP9 24920931 731599 Negative_regulation TNF DUSP1 20017901 353322 Negative_regulation TNF DUSP1 22315682 1687187 Negative_regulation TNF DUSP1 22540262 1899068 Negative_regulation TNF DUSP1 22540262 1899076 Negative_regulation TNF DUSP1 24265715 2885049 Negative_regulation TNF DUSP3 24901344 3068133 Negative_regulation TNF DUSP3 24901344 3068137 Negative_regulation TNF DYNLRB1 23638011 2786979 Negative_regulation TNF EDN1 24523936 2922092 Negative_regulation TNF EEF1A2 24445279 1940426 Negative_regulation TNF EHHADH 22049273 3102741 Negative_regulation TNF EIF2AK2 14979937 100179 Negative_regulation TNF EMD 23674918 629811 Negative_regulation TNF ENTPD2 25530618 1136242 Negative_regulation TNF EPGN 24444255 295657 Negative_regulation TNF EPHB2 19476641 1897229 Negative_regulation TNF EPHB2 20644716 2455936 Negative_regulation TNF EPHB2 21317295 717895 Negative_regulation TNF EPHB2 21451502 1918213 Negative_regulation TNF EPHB2 21853090 2543195 Negative_regulation TNF EPHB2 22384111 2604292 Negative_regulation TNF EPHB2 22455317 3210168 Negative_regulation TNF EPHB2 24191131 1754976 Negative_regulation TNF EPHB2 24191131 1754992 Negative_regulation TNF EPHB2 24789665 1886417 Negative_regulation TNF EPO 22043313 2566118 Negative_regulation TNF EPO 24350257 185853 Negative_regulation TNF EPO 24529189 1900132 Negative_regulation TNF ERBB2 22157714 1717764 Negative_regulation TNF ERP27 24385881 3155771 Negative_regulation TNF ERP29 24385881 3155769 Negative_regulation TNF ERP44 24385881 3155770 Negative_regulation TNF ETF1 10339451 789285 Negative_regulation TNF ETS1 22294049 1918684 Negative_regulation TNF EXOSC10 18282094 3040857 Negative_regulation TNF EXOSC2 18282094 3040850 Negative_regulation TNF EXOSC4 18282094 3040852 Negative_regulation TNF F11 19210794 365555 Negative_regulation TNF F11 19210794 365556 Negative_regulation TNF F11 19210794 365557 Negative_regulation TNF F2RL1 22175012 1686822 Negative_regulation TNF F2RL1 22731117 1663835 Negative_regulation TNF F2RL1 24534191 1575071 Negative_regulation TNF FANCD2 21912593 2552130 Negative_regulation TNF FANCD2 21912593 2552131 Negative_regulation TNF FANCD2 21912593 2552134 Negative_regulation TNF FANCD2 21912593 2552136 Negative_regulation TNF FAS 11581316 1521099 Negative_regulation TNF FAS 20703326 648134 Negative_regulation TNF FAS 25561921 1149707 Negative_regulation TNF FASLG 19641635 1909322 Negative_regulation TNF FASLG 21562052 1637161 Negative_regulation TNF FCN1 23884105 220672 Negative_regulation TNF FFAR4 23049242 1224918 Negative_regulation TNF FGB 23208413 2110597 Negative_regulation TNF FGFR3 18922179 1722749 Negative_regulation TNF FGFR3 21810260 1697635 Negative_regulation TNF FGFR3 22639569 930672 Negative_regulation TNF FGFR3 23023166 1023603 Negative_regulation TNF FGFR3 23691339 1151763 Negative_regulation TNF FGFR3 23936328 2829947 Negative_regulation TNF FGFR3 24733966 1758191 Negative_regulation TNF FGFR3 24914105 1684429 Negative_regulation TNF FGFR3 25197314 826840 Negative_regulation TNF FLOT2 18475487 1743994 Negative_regulation TNF FLOT2 18475487 1744013 Negative_regulation TNF FLOT2 23671449 95732 Negative_regulation TNF FMR1 PMC3301259 660918 Negative_regulation TNF FOS 23805228 2807960 Negative_regulation TNF FOS 24304472 1482124 Negative_regulation TNF FOS 24304472 1482148 Negative_regulation TNF FOXO1 24864265 191781 Negative_regulation TNF FUT1 25180025 1761900 Negative_regulation TNF FUT10 25180025 1761899 Negative_regulation TNF FUT11 25180025 1761898 Negative_regulation TNF FUT2 25180025 1761901 Negative_regulation TNF FUT3 25180025 1761902 Negative_regulation TNF FUT4 25180025 1761903 Negative_regulation TNF FUT5 25180025 1761904 Negative_regulation TNF FUT6 25180025 1761905 Negative_regulation TNF FUT7 25180025 1761906 Negative_regulation TNF FUT8 25180025 1761907 Negative_regulation TNF FUT9 25180025 1761908 Negative_regulation TNF FYN 19888448 2430217 Negative_regulation TNF GAL 23965627 1990869 Negative_regulation TNF GAS6 23533150 452335 Negative_regulation TNF GAST 22719247 3057135 Negative_regulation TNF GBP1 22692453 1918859 Negative_regulation TNF GDF15 16259055 3230771 Negative_regulation TNF GDF15 25541611 731146 Negative_regulation TNF GDF9 23565150 2777018 Negative_regulation TNF GFAP 19247457 1908998 Negative_regulation TNF GP2 10360649 414276 Negative_regulation TNF GP5 10360649 414277 Negative_regulation TNF GP6 10360649 414275 Negative_regulation TNF GP9 10360649 414278 Negative_regulation TNF GPI 22518279 1079938 Negative_regulation TNF GPI 22558080 2624246 Negative_regulation TNF GPNMB 18402690 315293 Negative_regulation TNF GPR1 23049242 1224972 Negative_regulation TNF GPR1 24911523 2977729 Negative_regulation TNF GPR101 23049242 1224928 Negative_regulation TNF GPR101 24911523 2977685 Negative_regulation TNF GPR107 23049242 1224933 Negative_regulation TNF GPR107 24911523 2977690 Negative_regulation TNF GPR108 23049242 1224932 Negative_regulation TNF GPR108 24911523 2977689 Negative_regulation TNF GPR110 23049242 1224938 Negative_regulation TNF GPR110 24911523 2977695 Negative_regulation TNF GPR111 23049242 1224939 Negative_regulation TNF GPR111 24911523 2977696 Negative_regulation TNF GPR112 23049242 1224940 Negative_regulation TNF GPR112 24911523 2977697 Negative_regulation TNF GPR113 23049242 1224937 Negative_regulation TNF GPR113 24911523 2977694 Negative_regulation TNF GPR114 23049242 1224941 Negative_regulation TNF GPR114 24911523 2977698 Negative_regulation TNF GPR115 23049242 1224942 Negative_regulation TNF GPR115 24911523 2977699 Negative_regulation TNF GPR116 23049242 1224943 Negative_regulation TNF GPR116 24911523 2977700 Negative_regulation TNF GPR119 23049242 1224944 Negative_regulation TNF GPR119 24911523 2977701 Negative_regulation TNF GPR12 23049242 1224973 Negative_regulation TNF GPR12 24911523 2977730 Negative_regulation TNF GPR123 23049242 1224925 Negative_regulation TNF GPR123 24911523 2977682 Negative_regulation TNF GPR124 23049242 1224934 Negative_regulation TNF GPR124 24911523 2977691 Negative_regulation TNF GPR125 23049242 1224926 Negative_regulation TNF GPR125 24911523 2977683 Negative_regulation TNF GPR126 23049242 1224927 Negative_regulation TNF GPR126 24911523 2977684 Negative_regulation TNF GPR128 23049242 1224945 Negative_regulation TNF GPR128 24911523 2977702 Negative_regulation TNF GPR132 23049242 1224931 Negative_regulation TNF GPR132 24911523 2977688 Negative_regulation TNF GPR133 23049242 1224946 Negative_regulation TNF GPR133 24911523 2977703 Negative_regulation TNF GPR135 23049242 1224947 Negative_regulation TNF GPR135 24911523 2977704 Negative_regulation TNF GPR137 23049242 1224965 Negative_regulation TNF GPR137 24911523 2977722 Negative_regulation TNF GPR139 23049242 1224948 Negative_regulation TNF GPR139 24911523 2977705 Negative_regulation TNF GPR141 23049242 1224949 Negative_regulation TNF GPR141 24911523 2977706 Negative_regulation TNF GPR142 23049242 1224950 Negative_regulation TNF GPR142 24911523 2977707 Negative_regulation TNF GPR143 23049242 1224951 Negative_regulation TNF GPR143 24911523 2977708 Negative_regulation TNF GPR144 23049242 1224936 Negative_regulation TNF GPR144 24911523 2977693 Negative_regulation TNF GPR146 23049242 1224953 Negative_regulation TNF GPR146 24911523 2977710 Negative_regulation TNF GPR148 23049242 1224957 Negative_regulation TNF GPR148 24911523 2977714 Negative_regulation TNF GPR149 23049242 1224959 Negative_regulation TNF GPR149 24911523 2977716 Negative_regulation TNF GPR15 23049242 1224974 Negative_regulation TNF GPR15 24911523 2977731 Negative_regulation TNF GPR150 23049242 1224960 Negative_regulation TNF GPR150 24911523 2977717 Negative_regulation TNF GPR151 23049242 1224958 Negative_regulation TNF GPR151 24911523 2977715 Negative_regulation TNF GPR152 23049242 1224956 Negative_regulation TNF GPR152 24911523 2977713 Negative_regulation TNF GPR153 23049242 1224955 Negative_regulation TNF GPR153 24911523 2977712 Negative_regulation TNF GPR155 23049242 1224954 Negative_regulation TNF GPR155 24911523 2977711 Negative_regulation TNF GPR156 23049242 1224952 Negative_regulation TNF GPR156 24911523 2977709 Negative_regulation TNF GPR157 23049242 1224961 Negative_regulation TNF GPR157 24911523 2977718 Negative_regulation TNF GPR158 23049242 1224962 Negative_regulation TNF GPR158 24911523 2977719 Negative_regulation TNF GPR160 23049242 1224963 Negative_regulation TNF GPR160 24911523 2977720 Negative_regulation TNF GPR161 23049242 1224964 Negative_regulation TNF GPR161 24911523 2977721 Negative_regulation TNF GPR162 23049242 1224929 Negative_regulation TNF GPR162 24911523 2977686 Negative_regulation TNF GPR17 23049242 1224975 Negative_regulation TNF GPR17 24911523 2977732 Negative_regulation TNF GPR171 23049242 1224967 Negative_regulation TNF GPR171 24911523 2977724 Negative_regulation TNF GPR173 23049242 1224935 Negative_regulation TNF GPR173 24911523 2977692 Negative_regulation TNF GPR174 23049242 1224968 Negative_regulation TNF GPR174 24911523 2977725 Negative_regulation TNF GPR176 23049242 1224971 Negative_regulation TNF GPR176 24911523 2977728 Negative_regulation TNF GPR179 23049242 1224970 Negative_regulation TNF GPR179 24911523 2977727 Negative_regulation TNF GPR18 23049242 1224976 Negative_regulation TNF GPR18 24911523 2977733 Negative_regulation TNF GPR180 23049242 1224966 Negative_regulation TNF GPR180 24911523 2977723 Negative_regulation TNF GPR182 23049242 1224923 Negative_regulation TNF GPR182 24911523 2977680 Negative_regulation TNF GPR183 23049242 1224969 Negative_regulation TNF GPR183 24911523 2977726 Negative_regulation TNF GPR19 23049242 1224977 Negative_regulation TNF GPR19 24911523 2977734 Negative_regulation TNF GPR20 23049242 1224978 Negative_regulation TNF GPR20 24911523 2977735 Negative_regulation TNF GPR21 23049242 1224979 Negative_regulation TNF GPR21 24911523 2977736 Negative_regulation TNF GPR22 23049242 1224980 Negative_regulation TNF GPR22 24911523 2977737 Negative_regulation TNF GPR25 23049242 1224981 Negative_regulation TNF GPR25 24911523 2977738 Negative_regulation TNF GPR26 23049242 1224982 Negative_regulation TNF GPR26 24911523 2977739 Negative_regulation TNF GPR27 23049242 1224983 Negative_regulation TNF GPR27 24911523 2977740 Negative_regulation TNF GPR3 23049242 1224984 Negative_regulation TNF GPR3 24911523 2977741 Negative_regulation TNF GPR31 23049242 1224985 Negative_regulation TNF GPR31 24911523 2977742 Negative_regulation TNF GPR32 23049242 1224986 Negative_regulation TNF GPR32 24911523 2977743 Negative_regulation TNF GPR33 23049242 1224987 Negative_regulation TNF GPR33 24911523 2977744 Negative_regulation TNF GPR34 23049242 1224988 Negative_regulation TNF GPR34 24911523 2977745 Negative_regulation TNF GPR35 23049242 1224989 Negative_regulation TNF GPR35 23922504 1145328 Negative_regulation TNF GPR35 24693337 2228565 Negative_regulation TNF GPR35 24911523 2977746 Negative_regulation TNF GPR36 23049242 1224990 Negative_regulation TNF GPR36 24911523 2977747 Negative_regulation TNF GPR37 23049242 1224991 Negative_regulation TNF GPR37 24911523 2977748 Negative_regulation TNF GPR39 23049242 1224992 Negative_regulation TNF GPR39 24911523 2977749 Negative_regulation TNF GPR4 23049242 1224993 Negative_regulation TNF GPR4 24911523 2977750 Negative_regulation TNF GPR42 23049242 1224994 Negative_regulation TNF GPR42 24911523 2977751 Negative_regulation TNF GPR45 23049242 1224995 Negative_regulation TNF GPR45 24911523 2977752 Negative_regulation TNF GPR50 23049242 1224996 Negative_regulation TNF GPR50 24911523 2977753 Negative_regulation TNF GPR52 23049242 1224997 Negative_regulation TNF GPR52 24911523 2977754 Negative_regulation TNF GPR55 23049242 1224998 Negative_regulation TNF GPR55 24911523 2977755 Negative_regulation TNF GPR56 23049242 1224999 Negative_regulation TNF GPR56 24911523 2977756 Negative_regulation TNF GPR6 23049242 1225000 Negative_regulation TNF GPR6 24911523 2977757 Negative_regulation TNF GPR61 23049242 1224920 Negative_regulation TNF GPR61 24911523 2977677 Negative_regulation TNF GPR62 23049242 1224921 Negative_regulation TNF GPR62 24911523 2977678 Negative_regulation TNF GPR63 23049242 1224922 Negative_regulation TNF GPR63 24911523 2977679 Negative_regulation TNF GPR64 23049242 1225001 Negative_regulation TNF GPR64 24911523 2977758 Negative_regulation TNF GPR65 19479052 2417570 Negative_regulation TNF GPR65 19479052 2417574 Negative_regulation TNF GPR65 23049242 1225002 Negative_regulation TNF GPR65 24911523 2977759 Negative_regulation TNF GPR68 19479052 2417571 Negative_regulation TNF GPR68 19479052 2417575 Negative_regulation TNF GPR68 23049242 1225003 Negative_regulation TNF GPR68 24911523 2977760 Negative_regulation TNF GPR75 23049242 1225005 Negative_regulation TNF GPR75 24911523 2977762 Negative_regulation TNF GPR78 23049242 1225006 Negative_regulation TNF GPR78 24911523 2977763 Negative_regulation TNF GPR79 23049242 1225007 Negative_regulation TNF GPR79 24911523 2977764 Negative_regulation TNF GPR82 23049242 1225008 Negative_regulation TNF GPR82 24911523 2977765 Negative_regulation TNF GPR83 23049242 1225004 Negative_regulation TNF GPR83 24911523 2977761 Negative_regulation TNF GPR84 23049242 1225009 Negative_regulation TNF GPR84 24911523 2977766 Negative_regulation TNF GPR85 23049242 1225010 Negative_regulation TNF GPR85 24911523 2977767 Negative_regulation TNF GPR87 23049242 1225011 Negative_regulation TNF GPR87 24911523 2977768 Negative_regulation TNF GPR88 23049242 1225012 Negative_regulation TNF GPR88 24911523 2977769 Negative_regulation TNF GPR97 23049242 1224924 Negative_regulation TNF GPR97 24911523 2977681 Negative_regulation TNF GPR98 23049242 1224930 Negative_regulation TNF GPR98 24911523 2977687 Negative_regulation TNF GPS2 23549795 3233072 Negative_regulation TNF GPX1 14960194 656445 Negative_regulation TNF GPX1 24381587 23158 Negative_regulation TNF GPX2 14960194 656446 Negative_regulation TNF GPX2 24381587 23159 Negative_regulation TNF GPX3 14960194 656447 Negative_regulation TNF GPX3 24381587 23160 Negative_regulation TNF GPX4 14960194 656448 Negative_regulation TNF GPX4 24381587 23161 Negative_regulation TNF GPX5 14960194 656449 Negative_regulation TNF GPX5 24381587 23162 Negative_regulation TNF GPX6 14960194 656450 Negative_regulation TNF GPX6 24381587 23163 Negative_regulation TNF GPX7 14960194 656451 Negative_regulation TNF GPX7 24381587 23164 Negative_regulation TNF GPX8 14960194 656444 Negative_regulation TNF GPX8 24381587 23157 Negative_regulation TNF GRAP2 22675384 814577 Negative_regulation TNF GRIA4 24344780 1667475 Negative_regulation TNF GTS 23431333 817284 Negative_regulation TNF GTS 25136575 197174 Negative_regulation TNF GTS 25136575 197175 Negative_regulation TNF HBZ 24068936 3064204 Negative_regulation TNF HCLS1 8666940 1597387 Negative_regulation TNF HDAC1 20419126 2447045 Negative_regulation TNF HDAC1 20579762 1619890 Negative_regulation TNF HDAC1 22022321 923670 Negative_regulation TNF HDAC10 22022321 923668 Negative_regulation TNF HDAC11 22022321 923669 Negative_regulation TNF HDAC2 20419126 2447046 Negative_regulation TNF HDAC2 22022321 923671 Negative_regulation TNF HDAC3 22022321 923672 Negative_regulation TNF HDAC3 23549795 3233073 Negative_regulation TNF HDAC4 22022321 923663 Negative_regulation TNF HDAC4 24086512 2854452 Negative_regulation TNF HDAC4 25187650 1830489 Negative_regulation TNF HDAC5 22022321 923667 Negative_regulation TNF HDAC6 22022321 923664 Negative_regulation TNF HDAC7 22022321 923666 Negative_regulation TNF HDAC8 22022321 923662 Negative_regulation TNF HDAC9 22022321 923665 Negative_regulation TNF HES1 20937119 845870 Negative_regulation TNF HES2 20937119 845865 Negative_regulation TNF HES3 20937119 845869 Negative_regulation TNF HES4 20937119 845868 Negative_regulation TNF HES5 20937119 845867 Negative_regulation TNF HES6 20937119 845866 Negative_regulation TNF HES7 20937119 845864 Negative_regulation TNF HGF 22536224 980463 Negative_regulation TNF HGF 23715119 1709394 Negative_regulation TNF HGF 25119536 505043 Negative_regulation TNF HGS 24857932 2973157 Negative_regulation TNF HIRA 24550644 1636180 Negative_regulation TNF HIST2H3A 19183807 2405074 Negative_regulation TNF HLA-DOA 8920867 1599469 Negative_regulation TNF HLA-DRA 22566973 900657 Negative_regulation TNF HLA-DRB1 22566973 900658 Negative_regulation TNF HLA-G 23418570 2754457 Negative_regulation TNF HMGB1 21660935 808368 Negative_regulation TNF HMGB1 23874764 2822477 Negative_regulation TNF HMGB1 24578610 1085064 Negative_regulation TNF HMOX1 14960194 656443 Negative_regulation TNF HMOX1 22518279 1079921 Negative_regulation TNF HMOX1 22518295 1080015 Negative_regulation TNF HMOX1 23066659 313667 Negative_regulation TNF HMOX1 23525626 1490459 Negative_regulation TNF HMOX1 24009860 204012 Negative_regulation TNF HMOX1 24009860 204015 Negative_regulation TNF HMOX1 24086665 2855464 Negative_regulation TNF HMOX1 24205091 2875301 Negative_regulation TNF HMOX1 24503248 1685556 Negative_regulation TNF HNRNPF 12437786 1733970 Negative_regulation TNF HNRNPF 12566416 1525874 Negative_regulation TNF HNRNPF 15197227 1532933 Negative_regulation TNF HNRNPF 18195069 1548409 Negative_regulation TNF HNRNPF 18817542 352438 Negative_regulation TNF HNRNPF 21102427 1719821 Negative_regulation TNF HNRNPF 22279513 2219170 Negative_regulation TNF HNRNPH1 12437786 1733971 Negative_regulation TNF HNRNPH1 12566416 1525875 Negative_regulation TNF HNRNPH1 15197227 1532934 Negative_regulation TNF HNRNPH1 18195069 1548410 Negative_regulation TNF HNRNPH1 18817542 352439 Negative_regulation TNF HNRNPH1 21102427 1719822 Negative_regulation TNF HNRNPH1 22279513 2219171 Negative_regulation TNF HPR 24069363 2853100 Negative_regulation TNF HSF1 25053922 1627944 Negative_regulation TNF HSF1 25053922 1627954 Negative_regulation TNF HSPB1 24705157 984788 Negative_regulation TNF HSPB3 23592916 1915844 Negative_regulation TNF HSPB3 23592916 1915845 Negative_regulation TNF HSPD1 22485093 956799 Negative_regulation TNF HSPD1 23762847 182059 Negative_regulation TNF HSPD1 25552899 744057 Negative_regulation TNF HSPE1 22485093 956800 Negative_regulation TNF IARS 18981239 1552724 Negative_regulation TNF IARS 18981239 1552727 Negative_regulation TNF IARS 23690658 1751923 Negative_regulation TNF ICAM1 21269478 508403 Negative_regulation TNF ICAM1 21808585 1682042 Negative_regulation TNF ICAM1 22111033 730304 Negative_regulation TNF ICAM1 23285282 2733424 Negative_regulation TNF ICAM1 23671702 2792481 Negative_regulation TNF ICAM1 23929007 87356 Negative_regulation TNF ICAM1 24502696 1232948 Negative_regulation TNF ICAM1 25552899 743679 Negative_regulation TNF ID1 20010941 434219 Negative_regulation TNF ID1 20010941 434228 Negative_regulation TNF ID1 20010941 434232 Negative_regulation TNF IDO1 24550603 1757514 Negative_regulation TNF IDO1 25215657 1484969 Negative_regulation TNF IFIH1 18617992 3041648 Negative_regulation TNF IFN1@ 3110354 1580010 Negative_regulation TNF IFNG 24130911 2372246 Negative_regulation TNF IGF1 21371294 1657912 Negative_regulation TNF IGF1 25141822 1736214 Negative_regulation TNF IGFBP3 23383064 2747714 Negative_regulation TNF IGFBP3 24904844 90630 Negative_regulation TNF IGFBP3 25268946 3011800 Negative_regulation TNF IGKV1-27 22958952 1920500 Negative_regulation TNF IGKV1-27 23042150 1957906 Negative_regulation TNF IGKV1-27 24658543 2937796 Negative_regulation TNF IGKV1-27 24747594 1126217 Negative_regulation TNF IGKV1-27 24917867 913053 Negative_regulation TNF IGKV6D-21 12110119 98931 Negative_regulation TNF IKBKB 20814569 2473439 Negative_regulation TNF IKBKB 22046421 2567705 Negative_regulation TNF IKBKB 25762184 1623428 Negative_regulation TNF IKBKG 20814569 2473440 Negative_regulation TNF IKBKG 22046421 2567706 Negative_regulation TNF IKBKG 25762184 1623429 Negative_regulation TNF IL10 10408703 414812 Negative_regulation TNF IL10 11213909 1737733 Negative_regulation TNF IL10 12417634 1525207 Negative_regulation TNF IL10 12782719 1527577 Negative_regulation TNF IL10 14651749 3095626 Negative_regulation TNF IL10 14680506 99981 Negative_regulation TNF IL10 15566620 658573 Negative_regulation TNF IL10 15566620 658574 Negative_regulation TNF IL10 15784144 3211705 Negative_regulation TNF IL10 15899058 103805 Negative_regulation TNF IL10 15987484 103937 Negative_regulation TNF IL10 16168063 400959 Negative_regulation TNF IL10 16275760 1538134 Negative_regulation TNF IL10 16275760 1538135 Negative_regulation TNF IL10 16275760 1538136 Negative_regulation TNF IL10 16275760 1538209 Negative_regulation TNF IL10 16432252 1539314 Negative_regulation TNF IL10 16432252 1539315 Negative_regulation TNF IL10 17179678 1634775 Negative_regulation TNF IL10 17953477 2289555 Negative_regulation TNF IL10 18179717 991655 Negative_regulation TNF IL10 18179717 991656 Negative_regulation TNF IL10 18179717 991659 Negative_regulation TNF IL10 18303205 1635000 Negative_regulation TNF IL10 18442421 1043609 Negative_regulation TNF IL10 18463695 3041255 Negative_regulation TNF IL10 18472950 1743275 Negative_regulation TNF IL10 18796724 1613407 Negative_regulation TNF IL10 18937852 356898 Negative_regulation TNF IL10 19232107 352652 Negative_regulation TNF IL10 19454012 659235 Negative_regulation TNF IL10 19707398 175797 Negative_regulation TNF IL10 19884981 1746724 Negative_regulation TNF IL10 20016738 2114379 Negative_regulation TNF IL10 20027315 2435313 Negative_regulation TNF IL10 20027315 2435315 Negative_regulation TNF IL10 20827340 2114621 Negative_regulation TNF IL10 21152121 1081462 Negative_regulation TNF IL10 21152121 1081476 Negative_regulation TNF IL10 21339324 1562645 Negative_regulation TNF IL10 21345239 1697079 Negative_regulation TNF IL10 21447195 627015 Negative_regulation TNF IL10 21457509 659884 Negative_regulation TNF IL10 21637453 989503 Negative_regulation TNF IL10 21654841 988681 Negative_regulation TNF IL10 21861861 123773 Negative_regulation TNF IL10 21949832 2556773 Negative_regulation TNF IL10 21949832 2556783 Negative_regulation TNF IL10 21978632 1697869 Negative_regulation TNF IL10 22038545 5132 Negative_regulation TNF IL10 22123833 1394054 Negative_regulation TNF IL10 22132181 2574275 Negative_regulation TNF IL10 22190849 1223557 Negative_regulation TNF IL10 22192790 124459 Negative_regulation TNF IL10 22359543 2597599 Negative_regulation TNF IL10 22470449 2614188 Negative_regulation TNF IL10 22558240 2624811 Negative_regulation TNF IL10 22566778 3152672 Negative_regulation TNF IL10 22609835 14863 Negative_regulation TNF IL10 22693523 636262 Negative_regulation TNF IL10 22737152 902012 Negative_regulation TNF IL10 22783343 1028666 Negative_regulation TNF IL10 22851816 1750156 Negative_regulation TNF IL10 22966811 366907 Negative_regulation TNF IL10 22973511 623080 Negative_regulation TNF IL10 22988544 3174638 Negative_regulation TNF IL10 23049677 2698845 Negative_regulation TNF IL10 23049703 2699104 Negative_regulation TNF IL10 23060880 904604 Negative_regulation TNF IL10 23078757 660369 Negative_regulation TNF IL10 23091436 1038788 Negative_regulation TNF IL10 23134700 339563 Negative_regulation TNF IL10 23251798 3086795 Negative_regulation TNF IL10 23272193 2730121 Negative_regulation TNF IL10 23272193 2730131 Negative_regulation TNF IL10 23284599 2218898 Negative_regulation TNF IL10 23382730 905943 Negative_regulation TNF IL10 23440124 1764676 Negative_regulation TNF IL10 23516562 2768469 Negative_regulation TNF IL10 23533313 1751850 Negative_regulation TNF IL10 23555077 180684 Negative_regulation TNF IL10 23658645 2789466 Negative_regulation TNF IL10 23675368 878473 Negative_regulation TNF IL10 23844248 2819622 Negative_regulation TNF IL10 23861957 2821016 Negative_regulation TNF IL10 23869227 2821176 Negative_regulation TNF IL10 23980096 1573510 Negative_regulation TNF IL10 23984434 1495397 Negative_regulation TNF IL10 24058765 1705131 Negative_regulation TNF IL10 24069337 2852804 Negative_regulation TNF IL10 24130911 2372247 Negative_regulation TNF IL10 24191131 1754993 Negative_regulation TNF IL10 24288682 185444 Negative_regulation TNF IL10 24302815 1755337 Negative_regulation TNF IL10 24349452 2898076 Negative_regulation TNF IL10 24349609 2227671 Negative_regulation TNF IL10 24378112 1726690 Negative_regulation TNF IL10 24385940 1039788 Negative_regulation TNF IL10 24385940 1039793 Negative_regulation TNF IL10 24466141 2913691 Negative_regulation TNF IL10 24466200 2913906 Negative_regulation TNF IL10 24585413 3081701 Negative_regulation TNF IL10 24676654 1764731 Negative_regulation TNF IL10 24742125 132248 Negative_regulation TNF IL10 24743880 3066776 Negative_regulation TNF IL10 24744897 2251798 Negative_regulation TNF IL10 24744897 2251799 Negative_regulation TNF IL10 24744897 2251805 Negative_regulation TNF IL10 24812442 1758469 Negative_regulation TNF IL10 24872677 743012 Negative_regulation TNF IL10 24970341 1668294 Negative_regulation TNF IL10 25049659 136169 Negative_regulation TNF IL10 25066324 314711 Negative_regulation TNF IL10 25152735 965858 Negative_regulation TNF IL10 25184950 1129353 Negative_regulation TNF IL10 25184950 1129355 Negative_regulation TNF IL10 25187652 1621076 Negative_regulation TNF IL10 25264742 1131186 Negative_regulation TNF IL10 25264742 1131188 Negative_regulation TNF IL10 25326018 1148491 Negative_regulation TNF IL10 25552899 744115 Negative_regulation TNF IL10 25552899 744132 Negative_regulation TNF IL10 25624918 2170451 Negative_regulation TNF IL10 7836910 1592381 Negative_regulation TNF IL10 7964475 1593469 Negative_regulation TNF IL10 8163935 1594288 Negative_regulation TNF IL10 8163939 1594352 Negative_regulation TNF IL10 8245792 1594742 Negative_regulation TNF IL10 8245792 1594748 Negative_regulation TNF IL10 8426121 1595212 Negative_regulation TNF IL10 8691149 1598508 Negative_regulation TNF IL10 8760809 1598835 Negative_regulation TNF IL11 11094428 98165 Negative_regulation TNF IL12A 15813981 1624699 Negative_regulation TNF IL12A 18817542 352440 Negative_regulation TNF IL12A 19712464 353084 Negative_regulation TNF IL12A 20205812 1625971 Negative_regulation TNF IL12A 21792574 3090852 Negative_regulation TNF IL12A 22547990 3152609 Negative_regulation TNF IL12A 23205044 135858 Negative_regulation TNF IL12A 23533314 1751868 Negative_regulation TNF IL12A 23980098 1573539 Negative_regulation TNF IL12A 24116222 2865855 Negative_regulation TNF IL12B 15813981 1624700 Negative_regulation TNF IL12B 18817542 352441 Negative_regulation TNF IL12B 19712464 353085 Negative_regulation TNF IL12B 20205812 1625972 Negative_regulation TNF IL12B 21792574 3090853 Negative_regulation TNF IL12B 22547990 3152610 Negative_regulation TNF IL12B 23205044 135859 Negative_regulation TNF IL12B 23533314 1751869 Negative_regulation TNF IL12B 23980098 1573540 Negative_regulation TNF IL12B 24116222 2865856 Negative_regulation TNF IL13 22623923 901032 Negative_regulation TNF IL13 23055975 958977 Negative_regulation TNF IL13 23087507 1047610 Negative_regulation TNF IL13 23554645 1225827 Negative_regulation TNF IL13 23554645 1225844 Negative_regulation TNF IL13 7836910 1592361 Negative_regulation TNF IL17A 19400960 1655732 Negative_regulation TNF IL17A 20169058 2370623 Negative_regulation TNF IL17A 20205812 1625973 Negative_regulation TNF IL17A 21235788 3213846 Negative_regulation TNF IL17A 22855687 902725 Negative_regulation TNF IL17A 23634300 3204457 Negative_regulation TNF IL17A 24586980 2928502 Negative_regulation TNF IL17A 24586980 2928684 Negative_regulation TNF IL18 11489953 1520486 Negative_regulation TNF IL19 21106488 1031249 Negative_regulation TNF IL1A 12454768 422135 Negative_regulation TNF IL1A 18472817 1741760 Negative_regulation TNF IL1A 18475483 1743989 Negative_regulation TNF IL1A 20380722 118648 Negative_regulation TNF IL1A 20463965 2449868 Negative_regulation TNF IL1A 21054849 1228713 Negative_regulation TNF IL1A 21477368 3112061 Negative_regulation TNF IL1A 21663638 2112833 Negative_regulation TNF IL1A 21810260 1697636 Negative_regulation TNF IL1A 22363816 2602088 Negative_regulation TNF IL1A 22474480 634218 Negative_regulation TNF IL1A 22698256 1724696 Negative_regulation TNF IL1A 22802905 2219272 Negative_regulation TNF IL1A 23320032 816983 Negative_regulation TNF IL1A 23346196 817066 Negative_regulation TNF IL1A 23663236 1666719 Negative_regulation TNF IL1A 23904473 91442 Negative_regulation TNF IL1A 24278618 3180348 Negative_regulation TNF IL1A 24490798 1667689 Negative_regulation TNF IL1A 24705157 984952 Negative_regulation TNF IL1A 24914105 1684430 Negative_regulation TNF IL1A 24926352 844215 Negative_regulation TNF IL1A 24992681 2986587 Negative_regulation TNF IL1A 25067987 694748 Negative_regulation TNF IL1A 25187652 1621077 Negative_regulation TNF IL1A 25364907 3021843 Negative_regulation TNF IL1B 23087507 1047611 Negative_regulation TNF IL1B 24722524 2372588 Negative_regulation TNF IL1RN 12823855 99875 Negative_regulation TNF IL1RN 18475483 1743990 Negative_regulation TNF IL1RN 19851470 175896 Negative_regulation TNF IL1RN 21599903 1658442 Negative_regulation TNF IL1RN 21871094 123903 Negative_regulation TNF IL1RN 22566778 3152656 Negative_regulation TNF IL1RN 24490798 1667690 Negative_regulation TNF IL1RN 24490798 1667691 Negative_regulation TNF IL1RN 24729739 20654 Negative_regulation TNF IL2 17179678 1634776 Negative_regulation TNF IL2 22958596 1920494 Negative_regulation TNF IL2 25228909 627692 Negative_regulation TNF IL2 PMC2557556 450084 Negative_regulation TNF IL21 24574581 1757515 Negative_regulation TNF IL3 22963460 1698826 Negative_regulation TNF IL32 21423208 2138714 Negative_regulation TNF IL33 22355383 2597441 Negative_regulation TNF IL37 20935647 1954496 Negative_regulation TNF IL37 24629023 1701458 Negative_regulation TNF IL37 24629023 1701503 Negative_regulation TNF IL37 24629023 1701506 Negative_regulation TNF IL37 24733959 1758090 Negative_regulation TNF IL37 25226272 3007708 Negative_regulation TNF IL4 12775355 1738483 Negative_regulation TNF IL4 14638848 1529832 Negative_regulation TNF IL4 14638848 1529833 Negative_regulation TNF IL4 14638848 1529834 Negative_regulation TNF IL4 14638848 1529865 Negative_regulation TNF IL4 14638848 1529866 Negative_regulation TNF IL4 14638848 1529867 Negative_regulation TNF IL4 14638848 1529868 Negative_regulation TNF IL4 14638848 1529881 Negative_regulation TNF IL4 14638848 1529882 Negative_regulation TNF IL4 14638848 1529894 Negative_regulation TNF IL4 14638848 1529900 Negative_regulation TNF IL4 14638848 1529908 Negative_regulation TNF IL4 14638848 1529910 Negative_regulation TNF IL4 14638848 1529915 Negative_regulation TNF IL4 14638848 1529918 Negative_regulation TNF IL4 14638848 1529919 Negative_regulation TNF IL4 15169552 3104139 Negative_regulation TNF IL4 16076403 3211743 Negative_regulation TNF IL4 16111485 1620406 Negative_regulation TNF IL4 17953477 2289556 Negative_regulation TNF IL4 18472842 1742223 Negative_regulation TNF IL4 18475655 1745175 Negative_regulation TNF IL4 18475657 1745190 Negative_regulation TNF IL4 18475724 1745784 Negative_regulation TNF IL4 20701773 1657096 Negative_regulation TNF IL4 20701773 1657106 Negative_regulation TNF IL4 20701773 1657123 Negative_regulation TNF IL4 21253484 632255 Negative_regulation TNF IL4 22121382 1155930 Negative_regulation TNF IL4 22693523 636263 Negative_regulation TNF IL4 23055975 958978 Negative_regulation TNF IL4 24681566 1960063 Negative_regulation TNF IL4 24757680 189533 Negative_regulation TNF IL4 24876883 825970 Negative_regulation TNF IL4 25097724 652287 Negative_regulation TNF IL4 25228909 627693 Negative_regulation TNF IL4 25387665 1050604 Negative_regulation TNF IL4 7836910 1592362 Negative_regulation TNF IL4 7836910 1592372 Negative_regulation TNF IL4 8113691 1594199 Negative_regulation TNF IL4 9814597 702733 Negative_regulation TNF IL5 15169552 3104140 Negative_regulation TNF IL5 22963460 1698827 Negative_regulation TNF IL5 23201770 2117076 Negative_regulation TNF IL6 11544173 790162 Negative_regulation TNF IL6 12467526 1738281 Negative_regulation TNF IL6 12775355 1738484 Negative_regulation TNF IL6 1310100 1528318 Negative_regulation TNF IL6 14668095 1739206 Negative_regulation TNF IL6 15025777 658515 Negative_regulation TNF IL6 15899058 103806 Negative_regulation TNF IL6 16259641 395239 Negative_regulation TNF IL6 18268916 1071546 Negative_regulation TNF IL6 18416823 1722692 Negative_regulation TNF IL6 18472817 1741761 Negative_regulation TNF IL6 18475433 1743414 Negative_regulation TNF IL6 18475433 1743416 Negative_regulation TNF IL6 18475475 1743890 Negative_regulation TNF IL6 18475557 1744317 Negative_regulation TNF IL6 18475557 1744321 Negative_regulation TNF IL6 18475570 1744337 Negative_regulation TNF IL6 18475695 1745398 Negative_regulation TNF IL6 18475695 1745399 Negative_regulation TNF IL6 18475724 1745847 Negative_regulation TNF IL6 19043563 1746402 Negative_regulation TNF IL6 19116667 2404025 Negative_regulation TNF IL6 19148295 1746433 Negative_regulation TNF IL6 20161729 2440510 Negative_regulation TNF IL6 20361002 2214376 Negative_regulation TNF IL6 20461197 2114543 Negative_regulation TNF IL6 21116333 742412 Negative_regulation TNF IL6 21253481 1748717 Negative_regulation TNF IL6 21255427 392305 Negative_regulation TNF IL6 21276212 508410 Negative_regulation TNF IL6 21294864 121394 Negative_regulation TNF IL6 21599903 1658443 Negative_regulation TNF IL6 21810260 1697637 Negative_regulation TNF IL6 21941676 1082279 Negative_regulation TNF IL6 22121130 91005 Negative_regulation TNF IL6 22189182 1230024 Negative_regulation TNF IL6 22189182 1230025 Negative_regulation TNF IL6 22254027 2115979 Negative_regulation TNF IL6 22272193 832505 Negative_regulation TNF IL6 22272381 1082515 Negative_regulation TNF IL6 22429752 660212 Negative_regulation TNF IL6 22474527 814130 Negative_regulation TNF IL6 22698256 1724697 Negative_regulation TNF IL6 22829443 3175627 Negative_regulation TNF IL6 22928086 2224807 Negative_regulation TNF IL6 22956783 1637604 Negative_regulation TNF IL6 23078757 660370 Negative_regulation TNF IL6 23087507 1047612 Negative_regulation TNF IL6 23136554 1060890 Negative_regulation TNF IL6 23346196 817067 Negative_regulation TNF IL6 23383221 2749527 Negative_regulation TNF IL6 23481064 1045260 Negative_regulation TNF IL6 23505537 2766826 Negative_regulation TNF IL6 23663236 1666720 Negative_regulation TNF IL6 23734186 2799531 Negative_regulation TNF IL6 23853427 1754086 Negative_regulation TNF IL6 24137208 843518 Negative_regulation TNF IL6 24563869 1495681 Negative_regulation TNF IL6 24681566 1960064 Negative_regulation TNF IL6 24722524 2372589 Negative_regulation TNF IL6 24733068 1126079 Negative_regulation TNF IL6 24772064 869142 Negative_regulation TNF IL6 24914105 1684431 Negative_regulation TNF IL6 24992681 2986588 Negative_regulation TNF IL6 25045212 1760208 Negative_regulation TNF IL6 25120616 844874 Negative_regulation TNF IL6 25202189 1682286 Negative_regulation TNF IL6 25264981 3010833 Negative_regulation TNF IL6 7530764 1589965 Negative_regulation TNF IL6 7931061 1593072 Negative_regulation TNF IL6 8180022 444619 Negative_regulation TNF IL6 8353036 444741 Negative_regulation TNF IL6 9888463 448056 Negative_regulation TNF IL8 12493069 658429 Negative_regulation TNF IL8 18410682 110457 Negative_regulation TNF IL8 21810260 1697638 Negative_regulation TNF IL8 22014750 211761 Negative_regulation TNF IL8 22254027 2115980 Negative_regulation TNF IL8 23505537 2766827 Negative_regulation TNF IL8 23533479 817798 Negative_regulation TNF IL8 23533479 817799 Negative_regulation TNF IL8 23770053 1498337 Negative_regulation TNF IL8 24205328 2876002 Negative_regulation TNF IL8 24914105 1684432 Negative_regulation TNF IL8 25054074 1083006 Negative_regulation TNF IL8 25352548 2105756 Negative_regulation TNF IL8 9839698 1764088 Negative_regulation TNF INHBA 22899878 1750214 Negative_regulation TNF INS 19558671 1722866 Negative_regulation TNF INS 21639905 1626378 Negative_regulation TNF INS 22536561 1920866 Negative_regulation TNF INS 22536561 1920867 Negative_regulation TNF INS 23155382 2716988 Negative_regulation TNF INS 23862164 1495357 Negative_regulation TNF INSR 22942720 1097112 Negative_regulation TNF INSRR 21791449 90910 Negative_regulation TNF IPO11 22035453 1229739 Negative_regulation TNF IPO11 22035453 1229740 Negative_regulation TNF IPO11 25322861 1886881 Negative_regulation TNF IPO13 22035453 1229733 Negative_regulation TNF IPO13 22035453 1229734 Negative_regulation TNF IPO13 25322861 1886878 Negative_regulation TNF IPO4 22035453 1229737 Negative_regulation TNF IPO4 22035453 1229738 Negative_regulation TNF IPO4 25322861 1886880 Negative_regulation TNF IPO5 22035453 1229741 Negative_regulation TNF IPO5 22035453 1229742 Negative_regulation TNF IPO5 25322861 1886882 Negative_regulation TNF IPO7 22035453 1229743 Negative_regulation TNF IPO7 22035453 1229744 Negative_regulation TNF IPO7 25322861 1886883 Negative_regulation TNF IPO8 22035453 1229745 Negative_regulation TNF IPO8 22035453 1229746 Negative_regulation TNF IPO8 25322861 1886884 Negative_regulation TNF IPO9 22035453 1229735 Negative_regulation TNF IPO9 22035453 1229736 Negative_regulation TNF IPO9 25322861 1886879 Negative_regulation TNF IRAK1 18759964 111132 Negative_regulation TNF IRAK1 22496647 3056088 Negative_regulation TNF IRAK1 24939082 1087411 Negative_regulation TNF IRAK3 23634235 2225813 Negative_regulation TNF IRAK3 25629008 865428 Negative_regulation TNF IRAK4 23527164 2769750 Negative_regulation TNF IRF1 19487420 1554884 Negative_regulation TNF IRF7 19934004 711876 Negative_regulation TNF IRF8 19487420 1554883 Negative_regulation TNF IRS1 22942720 1097113 Negative_regulation TNF ITCH 19262463 764083 Negative_regulation TNF ITGAM 23674977 1064310 Negative_regulation TNF ITIH4 25036364 2990691 Negative_regulation TNF ITLN1 22108456 508636 Negative_regulation TNF JUN 22199113 1045047 Negative_regulation TNF JUN 22690271 2224390 Negative_regulation TNF JUN 23755222 2802100 Negative_regulation TNF JUN 23803414 3121916 Negative_regulation TNF KHSRP 25352548 2105850 Negative_regulation TNF KIT 24206648 367423 Negative_regulation TNF KLF2 24228622 359359 Negative_regulation TNF KLF4 24470523 1159216 Negative_regulation TNF KLF4 24470523 1159217 Negative_regulation TNF KLF4 24470523 1159218 Negative_regulation TNF KLF4 24470523 1159225 Negative_regulation TNF KLF4 24470523 1159234 Negative_regulation TNF KLF4 24470523 1159238 Negative_regulation TNF KLF4 24470523 1159254 Negative_regulation TNF KLF4 24470523 1159262 Negative_regulation TNF KLK5 24534191 1575072 Negative_regulation TNF KLRC1 25251060 3010057 Negative_regulation TNF KLRG1 22891217 724143 Negative_regulation TNF LBP 20846396 353605 Negative_regulation TNF LBP 23437199 2756172 Negative_regulation TNF LBP 25025695 2989394 Negative_regulation TNF LGALS4 18612433 2392749 Negative_regulation TNF LGALS4 18612433 2392750 Negative_regulation TNF LGALS4 18612433 2392754 Negative_regulation TNF LGALS9 23118999 2712431 Negative_regulation TNF LGALS9 23139902 452313 Negative_regulation TNF LIF 20186338 2441704 Negative_regulation TNF LIF 24659953 869064 Negative_regulation TNF LIG1 20581853 10175 Negative_regulation TNF LIG1 23805245 2808011 Negative_regulation TNF LIG3 20581853 10176 Negative_regulation TNF LIG3 23805245 2808012 Negative_regulation TNF LIG4 20581853 10177 Negative_regulation TNF LIG4 23805245 2808013 Negative_regulation TNF LIM2 22297446 806720 Negative_regulation TNF LIN28A 25313561 3015262 Negative_regulation TNF LIN37 24711995 188535 Negative_regulation TNF LIN52 24711995 188532 Negative_regulation TNF LIN54 24711995 188533 Negative_regulation TNF LIN9 24711995 188534 Negative_regulation TNF LITAF 21984950 2561248 Negative_regulation TNF LOX 24971753 2985050 Negative_regulation TNF LPA 8920850 1599300 Negative_regulation TNF LPL 22028972 154556 Negative_regulation TNF LRRK2 23190742 1665197 Negative_regulation TNF LSS 22518279 1079927 Negative_regulation TNF LSS 22518279 1079934 Negative_regulation TNF LSS 22518279 1079939 Negative_regulation TNF LSS 22518279 1079972 Negative_regulation TNF LTA 19966777 1960879 Negative_regulation TNF LTA 19966777 1960906 Negative_regulation TNF LTA 24171786 1627697 Negative_regulation TNF LTA 3279996 443320 Negative_regulation TNF LTF 21042560 1912103 Negative_regulation TNF LTF 24816278 2962904 Negative_regulation TNF LYPLA1 19272168 1226966 Negative_regulation TNF MAGT1 24434512 570896 Negative_regulation TNF MAP2K1 18282094 3040946 Negative_regulation TNF MAP2K1 19232066 112920 Negative_regulation TNF MAP2K1 21054880 508233 Negative_regulation TNF MAP2K1 22069638 3182916 Negative_regulation TNF MAP2K1 22455317 3210169 Negative_regulation TNF MAP2K2 18282094 3040947 Negative_regulation TNF MAP2K3 18282094 3040948 Negative_regulation TNF MAP2K4 18282094 3040949 Negative_regulation TNF MAP2K5 18282094 3040950 Negative_regulation TNF MAP2K6 18282094 3040951 Negative_regulation TNF MAP2K7 18282094 3040952 Negative_regulation TNF MAP3K11 21194439 1657666 Negative_regulation TNF MAP3K5 22046421 2567707 Negative_regulation TNF MAP3K7 24434512 570897 Negative_regulation TNF MAP3K8 15575964 1844338 Negative_regulation TNF MAP3K8 15575964 1844346 Negative_regulation TNF MAPK1 15225374 101611 Negative_regulation TNF MAPK1 16581537 792575 Negative_regulation TNF MAPK1 17342245 810712 Negative_regulation TNF MAPK1 21451502 1918256 Negative_regulation TNF MAPK1 22455317 3210170 Negative_regulation TNF MAPK1 22675384 814578 Negative_regulation TNF MAPK1 22848503 2669167 Negative_regulation TNF MAPK1 23549267 1104733 Negative_regulation TNF MAPK1 23549267 1104734 Negative_regulation TNF MAPK1 23549267 1105199 Negative_regulation TNF MAPK1 23557259 3215516 Negative_regulation TNF MAPK1 24223607 639127 Negative_regulation TNF MAPK1 24523867 2921761 Negative_regulation TNF MAPK1 24982891 193531 Negative_regulation TNF MAPK1 25180066 2229976 Negative_regulation TNF MAPK1 25210730 3006615 Negative_regulation TNF MAPK10 15225374 101612 Negative_regulation TNF MAPK10 16581537 792576 Negative_regulation TNF MAPK10 17342245 810713 Negative_regulation TNF MAPK10 21451502 1918257 Negative_regulation TNF MAPK10 22455317 3210171 Negative_regulation TNF MAPK10 22675384 814579 Negative_regulation TNF MAPK10 22848503 2669168 Negative_regulation TNF MAPK10 23549267 1104735 Negative_regulation TNF MAPK10 23549267 1104736 Negative_regulation TNF MAPK10 23549267 1105200 Negative_regulation TNF MAPK10 23557259 3215517 Negative_regulation TNF MAPK10 24223607 639128 Negative_regulation TNF MAPK10 24523867 2921762 Negative_regulation TNF MAPK10 25180066 2229977 Negative_regulation TNF MAPK10 25210730 3006616 Negative_regulation TNF MAPK11 15225374 101613 Negative_regulation TNF MAPK11 16581537 792577 Negative_regulation TNF MAPK11 17342245 810714 Negative_regulation TNF MAPK11 21451502 1918258 Negative_regulation TNF MAPK11 22455317 3210172 Negative_regulation TNF MAPK11 22675384 814580 Negative_regulation TNF MAPK11 22848503 2669169 Negative_regulation TNF MAPK11 23549267 1104737 Negative_regulation TNF MAPK11 23549267 1104738 Negative_regulation TNF MAPK11 23549267 1105201 Negative_regulation TNF MAPK11 23557259 3215518 Negative_regulation TNF MAPK11 24223607 639129 Negative_regulation TNF MAPK11 24523867 2921763 Negative_regulation TNF MAPK11 25180066 2229978 Negative_regulation TNF MAPK11 25210730 3006617 Negative_regulation TNF MAPK12 15225374 101614 Negative_regulation TNF MAPK12 16581537 792578 Negative_regulation TNF MAPK12 17342245 810715 Negative_regulation TNF MAPK12 21451502 1918259 Negative_regulation TNF MAPK12 22455317 3210173 Negative_regulation TNF MAPK12 22675384 814581 Negative_regulation TNF MAPK12 22848503 2669170 Negative_regulation TNF MAPK12 23549267 1104739 Negative_regulation TNF MAPK12 23549267 1104740 Negative_regulation TNF MAPK12 23549267 1105202 Negative_regulation TNF MAPK12 23557259 3215519 Negative_regulation TNF MAPK12 24223607 639130 Negative_regulation TNF MAPK12 24523867 2921764 Negative_regulation TNF MAPK12 25180066 2229979 Negative_regulation TNF MAPK12 25210730 3006618 Negative_regulation TNF MAPK13 15225374 101615 Negative_regulation TNF MAPK13 16581537 792579 Negative_regulation TNF MAPK13 17342245 810716 Negative_regulation TNF MAPK13 21451502 1918260 Negative_regulation TNF MAPK13 22455317 3210174 Negative_regulation TNF MAPK13 22675384 814582 Negative_regulation TNF MAPK13 22848503 2669171 Negative_regulation TNF MAPK13 23549267 1104741 Negative_regulation TNF MAPK13 23549267 1104742 Negative_regulation TNF MAPK13 23549267 1105203 Negative_regulation TNF MAPK13 23557259 3215520 Negative_regulation TNF MAPK13 24223607 639131 Negative_regulation TNF MAPK13 24523867 2921765 Negative_regulation TNF MAPK13 25180066 2229980 Negative_regulation TNF MAPK13 25210730 3006619 Negative_regulation TNF MAPK14 15225374 101616 Negative_regulation TNF MAPK14 16581537 792580 Negative_regulation TNF MAPK14 17342245 810717 Negative_regulation TNF MAPK14 21451502 1918261 Negative_regulation TNF MAPK14 22455317 3210175 Negative_regulation TNF MAPK14 22675384 814583 Negative_regulation TNF MAPK14 22848503 2669172 Negative_regulation TNF MAPK14 23549267 1104743 Negative_regulation TNF MAPK14 23549267 1104744 Negative_regulation TNF MAPK14 23549267 1105204 Negative_regulation TNF MAPK14 23557259 3215521 Negative_regulation TNF MAPK14 24223607 639132 Negative_regulation TNF MAPK14 24523867 2921766 Negative_regulation TNF MAPK14 25180066 2229981 Negative_regulation TNF MAPK14 25210730 3006620 Negative_regulation TNF MAPK15 15225374 101610 Negative_regulation TNF MAPK15 16581537 792574 Negative_regulation TNF MAPK15 17342245 810711 Negative_regulation TNF MAPK15 21451502 1918255 Negative_regulation TNF MAPK15 22455317 3210167 Negative_regulation TNF MAPK15 22675384 814576 Negative_regulation TNF MAPK15 22848503 2669166 Negative_regulation TNF MAPK15 23549267 1104731 Negative_regulation TNF MAPK15 23549267 1104732 Negative_regulation TNF MAPK15 23549267 1105198 Negative_regulation TNF MAPK15 23557259 3215515 Negative_regulation TNF MAPK15 24223607 639126 Negative_regulation TNF MAPK15 24523867 2921760 Negative_regulation TNF MAPK15 25180066 2229975 Negative_regulation TNF MAPK15 25210730 3006614 Negative_regulation TNF MAPK3 15225374 101617 Negative_regulation TNF MAPK3 16581537 792581 Negative_regulation TNF MAPK3 17342245 810718 Negative_regulation TNF MAPK3 18822184 3212651 Negative_regulation TNF MAPK3 20827314 979313 Negative_regulation TNF MAPK3 21451502 1918262 Negative_regulation TNF MAPK3 22455317 3210176 Negative_regulation TNF MAPK3 22662179 2647141 Negative_regulation TNF MAPK3 22675384 814584 Negative_regulation TNF MAPK3 22848503 2669173 Negative_regulation TNF MAPK3 23549267 1104745 Negative_regulation TNF MAPK3 23549267 1104746 Negative_regulation TNF MAPK3 23549267 1105205 Negative_regulation TNF MAPK3 23557259 3215522 Negative_regulation TNF MAPK3 23663325 1154918 Negative_regulation TNF MAPK3 23671886 1495251 Negative_regulation TNF MAPK3 24223607 639133 Negative_regulation TNF MAPK3 24304472 1482125 Negative_regulation TNF MAPK3 24516119 1574938 Negative_regulation TNF MAPK3 24523867 2921767 Negative_regulation TNF MAPK3 24743742 573728 Negative_regulation TNF MAPK3 24982891 193532 Negative_regulation TNF MAPK3 25180066 2229982 Negative_regulation TNF MAPK3 25210730 3006621 Negative_regulation TNF MAPK4 15225374 101618 Negative_regulation TNF MAPK4 16581537 792582 Negative_regulation TNF MAPK4 17342245 810719 Negative_regulation TNF MAPK4 21451502 1918263 Negative_regulation TNF MAPK4 22455317 3210177 Negative_regulation TNF MAPK4 22675384 814585 Negative_regulation TNF MAPK4 22848503 2669174 Negative_regulation TNF MAPK4 23549267 1104747 Negative_regulation TNF MAPK4 23549267 1104748 Negative_regulation TNF MAPK4 23549267 1105206 Negative_regulation TNF MAPK4 23557259 3215523 Negative_regulation TNF MAPK4 24223607 639134 Negative_regulation TNF MAPK4 24523867 2921768 Negative_regulation TNF MAPK4 25180066 2229983 Negative_regulation TNF MAPK4 25210730 3006622 Negative_regulation TNF MAPK6 15225374 101619 Negative_regulation TNF MAPK6 16581537 792583 Negative_regulation TNF MAPK6 17342245 810720 Negative_regulation TNF MAPK6 21451502 1918264 Negative_regulation TNF MAPK6 22455317 3210178 Negative_regulation TNF MAPK6 22675384 814586 Negative_regulation TNF MAPK6 22848503 2669175 Negative_regulation TNF MAPK6 23549267 1104749 Negative_regulation TNF MAPK6 23549267 1104750 Negative_regulation TNF MAPK6 23549267 1105207 Negative_regulation TNF MAPK6 23557259 3215524 Negative_regulation TNF MAPK6 24223607 639135 Negative_regulation TNF MAPK6 24523867 2921769 Negative_regulation TNF MAPK6 25180066 2229984 Negative_regulation TNF MAPK6 25210730 3006623 Negative_regulation TNF MAPK7 15225374 101620 Negative_regulation TNF MAPK7 16581537 792584 Negative_regulation TNF MAPK7 17342245 810721 Negative_regulation TNF MAPK7 21451502 1918265 Negative_regulation TNF MAPK7 22455317 3210179 Negative_regulation TNF MAPK7 22675384 814587 Negative_regulation TNF MAPK7 22848503 2669176 Negative_regulation TNF MAPK7 23549267 1104751 Negative_regulation TNF MAPK7 23549267 1104752 Negative_regulation TNF MAPK7 23549267 1105208 Negative_regulation TNF MAPK7 23557259 3215525 Negative_regulation TNF MAPK7 24223607 639136 Negative_regulation TNF MAPK7 24523867 2921770 Negative_regulation TNF MAPK7 25180066 2229985 Negative_regulation TNF MAPK7 25210730 3006624 Negative_regulation TNF MAPK8 15225374 101621 Negative_regulation TNF MAPK8 16581537 792585 Negative_regulation TNF MAPK8 17342245 810722 Negative_regulation TNF MAPK8 21451502 1918266 Negative_regulation TNF MAPK8 22455317 3210180 Negative_regulation TNF MAPK8 22675384 814588 Negative_regulation TNF MAPK8 22848503 2669177 Negative_regulation TNF MAPK8 23549267 1104753 Negative_regulation TNF MAPK8 23549267 1104754 Negative_regulation TNF MAPK8 23549267 1105209 Negative_regulation TNF MAPK8 23557259 3215526 Negative_regulation TNF MAPK8 23587438 1666547 Negative_regulation TNF MAPK8 24223607 639137 Negative_regulation TNF MAPK8 24304472 1482132 Negative_regulation TNF MAPK8 24523867 2921771 Negative_regulation TNF MAPK8 25180066 2229986 Negative_regulation TNF MAPK8 25210730 3006625 Negative_regulation TNF MAPK9 15225374 101622 Negative_regulation TNF MAPK9 16581537 792586 Negative_regulation TNF MAPK9 17342245 810723 Negative_regulation TNF MAPK9 21451502 1918267 Negative_regulation TNF MAPK9 22455317 3210181 Negative_regulation TNF MAPK9 22675384 814589 Negative_regulation TNF MAPK9 22848503 2669178 Negative_regulation TNF MAPK9 23549267 1104755 Negative_regulation TNF MAPK9 23549267 1104756 Negative_regulation TNF MAPK9 23549267 1105210 Negative_regulation TNF MAPK9 23557259 3215527 Negative_regulation TNF MAPK9 23587438 1666548 Negative_regulation TNF MAPK9 24223607 639138 Negative_regulation TNF MAPK9 24523867 2921772 Negative_regulation TNF MAPK9 25180066 2229987 Negative_regulation TNF MAPK9 25210730 3006626 Negative_regulation TNF MAPKAPK2 20230629 402478 Negative_regulation TNF MAPKAPK2 22991685 1082645 Negative_regulation TNF MARCH8 23152062 558028 Negative_regulation TNF MBL2 21194488 354223 Negative_regulation TNF MBL2 21194488 354241 Negative_regulation TNF MBL2 23884105 220673 Negative_regulation TNF MBL2 24391778 2904451 Negative_regulation TNF MBL2 24391778 2904456 Negative_regulation TNF MBL2 7500012 1587103 Negative_regulation TNF ME2 19707466 175876 Negative_regulation TNF ME2 19707466 175877 Negative_regulation TNF ME2 25229058 199045 Negative_regulation TNF MED1 20454616 2449410 Negative_regulation TNF MED1 24741183 1047940 Negative_regulation TNF MED10 20454616 2449405 Negative_regulation TNF MED10 24741183 1047936 Negative_regulation TNF MED11 20454616 2449408 Negative_regulation TNF MED11 24741183 1047939 Negative_regulation TNF MED12 24741183 1047911 Negative_regulation TNF MED13 20454616 2449392 Negative_regulation TNF MED13 24741183 1047921 Negative_regulation TNF MED13L 20454616 2449393 Negative_regulation TNF MED13L 24741183 1047922 Negative_regulation TNF MED14 20454616 2449397 Negative_regulation TNF MED14 24741183 1047926 Negative_regulation TNF MED15 20454616 2449386 Negative_regulation TNF MED15 24741183 1047912 Negative_regulation TNF MED16 20454616 2449388 Negative_regulation TNF MED16 24741183 1047915 Negative_regulation TNF MED17 20454616 2449399 Negative_regulation TNF MED17 24741183 1047928 Negative_regulation TNF MED18 20454616 2449404 Negative_regulation TNF MED18 24741183 1047935 Negative_regulation TNF MED19 20454616 2449407 Negative_regulation TNF MED19 24741183 1047938 Negative_regulation TNF MED20 20454616 2449387 Negative_regulation TNF MED20 24741183 1047914 Negative_regulation TNF MED21 20454616 2449384 Negative_regulation TNF MED21 24741183 1047909 Negative_regulation TNF MED22 20454616 2449385 Negative_regulation TNF MED22 24741183 1047910 Negative_regulation TNF MED23 20454616 2449398 Negative_regulation TNF MED23 24741183 1047927 Negative_regulation TNF MED24 20454616 2449394 Negative_regulation TNF MED24 24741183 1047923 Negative_regulation TNF MED25 20454616 2449406 Negative_regulation TNF MED25 24741183 1047937 Negative_regulation TNF MED26 20454616 2449400 Negative_regulation TNF MED26 24741183 1047929 Negative_regulation TNF MED27 20454616 2449401 Negative_regulation TNF MED27 24741183 1047930 Negative_regulation TNF MED28 24741183 1047933 Negative_regulation TNF MED29 20454616 2449396 Negative_regulation TNF MED29 24741183 1047925 Negative_regulation TNF MED30 20454616 2449395 Negative_regulation TNF MED30 24741183 1047924 Negative_regulation TNF MED31 20454616 2449403 Negative_regulation TNF MED31 24741183 1047932 Negative_regulation TNF MED4 20454616 2449389 Negative_regulation TNF MED4 24741183 1047917 Negative_regulation TNF MED6 20454616 2449390 Negative_regulation TNF MED6 24741183 1047919 Negative_regulation TNF MED7 20454616 2449402 Negative_regulation TNF MED7 24741183 1047931 Negative_regulation TNF MED8 20454616 2449391 Negative_regulation TNF MED8 24741183 1047920 Negative_regulation TNF MED9 24741183 1047934 Negative_regulation TNF MET 20811626 2473304 Negative_regulation TNF MET 25060092 850500 Negative_regulation TNF MFGE8 22114683 2573407 Negative_regulation TNF MFGE8 22114683 2573418 Negative_regulation TNF MGAT5 22389815 1152752 Negative_regulation TNF MICE 24592323 847604 Negative_regulation TNF MIP 24454978 2228002 Negative_regulation TNF MIR146A 25187983 2372877 Negative_regulation TNF MIR223 22937006 2682675 Negative_regulation TNF MKL1 23305364 694094 Negative_regulation TNF MLST8 24516119 1574932 Negative_regulation TNF MME 25005778 297578 Negative_regulation TNF MME 25005778 297587 Negative_regulation TNF MMP1 23688423 314119 Negative_regulation TNF MMP10 23688423 314120 Negative_regulation TNF MMP11 23688423 314121 Negative_regulation TNF MMP12 23688423 314122 Negative_regulation TNF MMP12 25005778 297546 Negative_regulation TNF MMP13 22388073 14502 Negative_regulation TNF MMP13 23688423 314123 Negative_regulation TNF MMP13 23723167 780909 Negative_regulation TNF MMP14 23688423 314124 Negative_regulation TNF MMP14 25162582 3002859 Negative_regulation TNF MMP15 23688423 314125 Negative_regulation TNF MMP16 23688423 314126 Negative_regulation TNF MMP17 23688423 314127 Negative_regulation TNF MMP19 23688423 314128 Negative_regulation TNF MMP2 21573233 2523001 Negative_regulation TNF MMP2 21573233 2523011 Negative_regulation TNF MMP2 21573233 2523020 Negative_regulation TNF MMP2 23688423 314129 Negative_regulation TNF MMP20 23688423 314130 Negative_regulation TNF MMP21 23688423 314117 Negative_regulation TNF MMP24 23688423 314131 Negative_regulation TNF MMP25 23688423 314114 Negative_regulation TNF MMP26 23688423 314115 Negative_regulation TNF MMP27 23688423 314116 Negative_regulation TNF MMP28 23688423 314118 Negative_regulation TNF MMP3 23285075 2732386 Negative_regulation TNF MMP3 23688423 314132 Negative_regulation TNF MMP7 23688423 314133 Negative_regulation TNF MMP8 23688423 314134 Negative_regulation TNF MMP9 22761606 3075863 Negative_regulation TNF MMP9 23554800 1226274 Negative_regulation TNF MMP9 23587438 1666549 Negative_regulation TNF MMP9 23688423 314135 Negative_regulation TNF MMP9 24552146 295813 Negative_regulation TNF MOK 20672051 512978 Negative_regulation TNF MOK 24102034 1082927 Negative_regulation TNF MOK 24386004 825048 Negative_regulation TNF MOK 24625976 573000 Negative_regulation TNF MPO 21232147 508359 Negative_regulation TNF MPO 24090436 660557 Negative_regulation TNF MRXS5 25189717 626579 Negative_regulation TNF MSC 20169081 2441141 Negative_regulation TNF MSC 23227090 637102 Negative_regulation TNF MSC 23356521 3169293 Negative_regulation TNF MSC 23936322 2829933 Negative_regulation TNF MSH2 14612916 423797 Negative_regulation TNF MSH2 15104793 3095746 Negative_regulation TNF MSH2 20731841 381660 Negative_regulation TNF MSH2 23482896 935226 Negative_regulation TNF MSH2 23482896 935246 Negative_regulation TNF MSH3 14612916 423798 Negative_regulation TNF MSH3 15104793 3095747 Negative_regulation TNF MSH3 20731841 381661 Negative_regulation TNF MSH3 23482896 935227 Negative_regulation TNF MSH3 23482896 935247 Negative_regulation TNF MSH4 14612916 423799 Negative_regulation TNF MSH4 15104793 3095748 Negative_regulation TNF MSH4 20731841 381662 Negative_regulation TNF MSH4 23482896 935228 Negative_regulation TNF MSH4 23482896 935248 Negative_regulation TNF MSH5 14612916 423800 Negative_regulation TNF MSH5 15104793 3095749 Negative_regulation TNF MSH5 20731841 381663 Negative_regulation TNF MSH5 23482896 935229 Negative_regulation TNF MSH5 23482896 935249 Negative_regulation TNF MSH6 14612916 423801 Negative_regulation TNF MSH6 15104793 3095750 Negative_regulation TNF MSH6 20731841 381664 Negative_regulation TNF MSH6 23482896 935230 Negative_regulation TNF MSH6 23482896 935250 Negative_regulation TNF MSLN 21880146 1863104 Negative_regulation TNF MT-CO2 20497620 659616 Negative_regulation TNF MTA1 24692853 1757949 Negative_regulation TNF MTA2 24692853 1757950 Negative_regulation TNF MTA3 24692853 1757948 Negative_regulation TNF MTOR 24516119 1574937 Negative_regulation TNF MTX1 18354729 631087 Negative_regulation TNF MTX1 19019215 111991 Negative_regulation TNF MTX1 21339857 648052 Negative_regulation TNF MUC1 21655347 2370972 Negative_regulation TNF MUC1 24453426 1757027 Negative_regulation TNF MUC12 24453426 1757028 Negative_regulation TNF MUC13 24453426 1757029 Negative_regulation TNF MUC15 24453426 1757021 Negative_regulation TNF MUC16 24453426 1757022 Negative_regulation TNF MUC17 24453426 1757023 Negative_regulation TNF MUC19 24453426 1757020 Negative_regulation TNF MUC2 24453426 1757030 Negative_regulation TNF MUC20 24453426 1757025 Negative_regulation TNF MUC21 24453426 1757024 Negative_regulation TNF MUC22 24453426 1757026 Negative_regulation TNF MUC4 24453426 1757031 Negative_regulation TNF MUC6 24453426 1757032 Negative_regulation TNF MUC7 24453426 1757033 Negative_regulation TNF MUC8 24453426 1757034 Negative_regulation TNF MYD88 18650365 706633 Negative_regulation TNF MYD88 19675137 710823 Negative_regulation TNF MYD88 20396389 1747311 Negative_regulation TNF MYD88 21049294 665223 Negative_regulation TNF MYD88 21115688 1562056 Negative_regulation TNF MYD88 22144896 3054874 Negative_regulation TNF MYD88 23305364 694096 Negative_regulation TNF MYD88 23555964 2776288 Negative_regulation TNF MYD88 24595131 2930815 Negative_regulation TNF MYD88 25550115 1734384 Negative_regulation TNF MYLIP 18392144 1083697 Negative_regulation TNF MYLIP 19840932 1167002 Negative_regulation TNF MYLIP 21247879 2060228 Negative_regulation TNF MYLIP 21247879 2060230 Negative_regulation TNF MYLIP 21611196 2523829 Negative_regulation TNF MYLIP 21611196 2523830 Negative_regulation TNF MYLIP 21611196 2523831 Negative_regulation TNF MYLIP 21611196 2523844 Negative_regulation TNF MYLIP 21611196 2523845 Negative_regulation TNF MYLIP 21611196 2523854 Negative_regulation TNF MYLIP 21611196 2523864 Negative_regulation TNF MYLIP 21787439 123311 Negative_regulation TNF MYLIP 21962237 354706 Negative_regulation TNF MYLIP 22346770 1038433 Negative_regulation TNF MYLIP 22518321 1079156 Negative_regulation TNF MYLIP 22739741 1735551 Negative_regulation TNF MYLIP 22900099 2675235 Negative_regulation TNF MYLIP 22950459 1664992 Negative_regulation TNF MYLIP 22950459 1664996 Negative_regulation TNF MYLIP 22950459 1664997 Negative_regulation TNF MYLIP 22950459 1664999 Negative_regulation TNF MYLIP 22950459 1665000 Negative_regulation TNF MYLIP 22950459 1665005 Negative_regulation TNF MYLIP 22950459 1665008 Negative_regulation TNF MYLIP 22956783 1637603 Negative_regulation TNF MYLIP 23448104 1231967 Negative_regulation TNF MYLIP 23448136 245432 Negative_regulation TNF MYLIP 23516523 2768205 Negative_regulation TNF MYLIP 23516523 2768226 Negative_regulation TNF MYLIP 23633945 3060738 Negative_regulation TNF MYLIP 23638011 2786980 Negative_regulation TNF MYLIP 23979021 611301 Negative_regulation TNF MYLIP 23979021 611322 Negative_regulation TNF MYLIP 23979021 611325 Negative_regulation TNF MYLIP 24098322 2855798 Negative_regulation TNF MYLIP 24098322 2855800 Negative_regulation TNF MYLIP 24098322 2855801 Negative_regulation TNF MYLIP 24098322 2855802 Negative_regulation TNF MYLIP 24178713 3223573 Negative_regulation TNF MYLIP 24358114 2898539 Negative_regulation TNF MYLIP 24358127 2898569 Negative_regulation TNF MYLIP 24705038 2948710 Negative_regulation TNF MYLIP 24717937 1941384 Negative_regulation TNF MYLIP 24885472 1701848 Negative_regulation TNF MYLIP 24885472 1701856 Negative_regulation TNF MYLIP 24885472 1701857 Negative_regulation TNF MYLIP 24885472 1701866 Negative_regulation TNF MYLIP 24885472 1701873 Negative_regulation TNF MYLIP 25133393 2998481 Negative_regulation TNF MYLIP 25182190 381609 Negative_regulation TNF MYLIP 25268390 986561 Negative_regulation TNF MYLIP 25462570 3031232 Negative_regulation TNF NA 10704075 1736858 Negative_regulation TNF NA 14630568 830290 Negative_regulation TNF NA 15025765 658512 Negative_regulation TNF NA 15869713 1162703 Negative_regulation TNF NA 16630341 249336 Negative_regulation TNF NA 18369465 3041038 Negative_regulation TNF NA 18986521 1625139 Negative_regulation TNF NA 20420656 2232943 Negative_regulation TNF NA 20420656 2232944 Negative_regulation TNF NA 23181604 2233493 Negative_regulation TNF NA 23351387 695283 Negative_regulation TNF NA 23710319 1024285 Negative_regulation TNF NA 23936448 2830956 Negative_regulation TNF NA 23936448 2830957 Negative_regulation TNF NA 24048773 745680 Negative_regulation TNF NA 25165721 198432 Negative_regulation TNF NA 25248126 3009305 Negative_regulation TNF NAALADL1 22319556 2595431 Negative_regulation TNF NAMPT 20546557 3118937 Negative_regulation TNF NAPB 22723850 2654882 Negative_regulation TNF NAPB 22723850 2654883 Negative_regulation TNF NCAM1 19712464 353086 Negative_regulation TNF NCOR1 23549795 3233074 Negative_regulation TNF NFAT5 16027109 2016902 Negative_regulation TNF NFAT5 16027109 2016908 Negative_regulation TNF NFAT5 16027109 2016912 Negative_regulation TNF NFATC2 10952728 1516717 Negative_regulation TNF NFATC2 7650486 1591371 Negative_regulation TNF NFE2L2 25009785 3094568 Negative_regulation TNF NFKB1 11097212 702116 Negative_regulation TNF NFKB1 18822146 161148 Negative_regulation TNF NFKB1 18834508 583299 Negative_regulation TNF NFKB1 19257911 365626 Negative_regulation TNF NFKB1 22375551 1230312 Negative_regulation TNF NFKB1 22432004 2611478 Negative_regulation TNF NFKB1 23690819 637304 Negative_regulation TNF NFKB1 23976842 742708 Negative_regulation TNF NFKB1 24586568 2925502 Negative_regulation TNF NFKB1 PMC4291901 541431 Negative_regulation TNF NGF 23365678 2745511 Negative_regulation TNF NGF 24438745 131354 Negative_regulation TNF NLRP3 19196451 242367 Negative_regulation TNF NNAT 18591389 706316 Negative_regulation TNF NOD1 22203860 633931 Negative_regulation TNF NOD2 22203860 633932 Negative_regulation TNF NOD2 24319468 639229 Negative_regulation TNF NOD2 24722226 3066650 Negative_regulation TNF NOS1 11481030 312675 Negative_regulation TNF NOS1 22359588 2597938 Negative_regulation TNF NOS1 24499158 2113946 Negative_regulation TNF NOS1 24744897 2251796 Negative_regulation TNF NOS1 7520469 1589453 Negative_regulation TNF NOS2 22359588 2597939 Negative_regulation TNF NOS2 22715398 2652810 Negative_regulation TNF NOS2 22778500 1750125 Negative_regulation TNF NOS2 23035900 1231287 Negative_regulation TNF NOS2 23382985 2747508 Negative_regulation TNF NOS2 23781123 1753404 Negative_regulation TNF NOS2 23970812 1754528 Negative_regulation TNF NOS2 24009861 204019 Negative_regulation TNF NOS2 24499158 2113947 Negative_regulation TNF NOS2 25141004 3000417 Negative_regulation TNF NOS2 25314304 3015598 Negative_regulation TNF NOS2 25352548 2105757 Negative_regulation TNF NOS2 25435878 1074941 Negative_regulation TNF NOS2 9883971 1764120 Negative_regulation TNF NOS3 12172046 1632987 Negative_regulation TNF NOS3 22359588 2597940 Negative_regulation TNF NOS3 24499158 2113948 Negative_regulation TNF NOTCH1 24991087 1759990 Negative_regulation TNF NOTCH3 23531541 1103847 Negative_regulation TNF NOX1 16959029 1654952 Negative_regulation TNF NOX1 23887360 1905665 Negative_regulation TNF NOX1 24396568 2227981 Negative_regulation TNF NOX3 16959029 1654953 Negative_regulation TNF NOX3 23887360 1905666 Negative_regulation TNF NOX3 24396568 2227982 Negative_regulation TNF NOX4 16959029 1654954 Negative_regulation TNF NOX4 23887360 1905667 Negative_regulation TNF NOX4 24396568 2227983 Negative_regulation TNF NOX5 16959029 1654951 Negative_regulation TNF NOX5 23887360 1905664 Negative_regulation TNF NOX5 24396568 2227980 Negative_regulation TNF NPPA 24498225 2919018 Negative_regulation TNF NPPA PMC4095508 661343 Negative_regulation TNF NPS 24280677 2244851 Negative_regulation TNF NPY 16277701 104851 Negative_regulation TNF NPY 23011592 724871 Negative_regulation TNF NPY 25206918 2006446 Negative_regulation TNF NPY 25206918 2006447 Negative_regulation TNF NPY 25206918 2006532 Negative_regulation TNF NPY 25206918 2006642 Negative_regulation TNF NPY4R 23209344 1750752 Negative_regulation TNF NRG1 23936190 2829634 Negative_regulation TNF OCLN 23924897 1817700 Negative_regulation TNF OPA1 20454616 2449409 Negative_regulation TNF OPN1MW 19052649 1908491 Negative_regulation TNF OPN1MW 21244691 1657711 Negative_regulation TNF OPN1MW 21244691 1657715 Negative_regulation TNF OPN1MW 25105142 195965 Negative_regulation TNF OPTN 22675546 2649102 Negative_regulation TNF OPTN 22690120 1914501 Negative_regulation TNF OSM 24710357 2949656 Negative_regulation TNF P2RX7 17367517 1624963 Negative_regulation TNF P2RX7 23210974 356113 Negative_regulation TNF P4HB 18680601 658967 Negative_regulation TNF P4HB 18680601 658972 Negative_regulation TNF P4HB 18680601 658975 Negative_regulation TNF PAM 23284793 2730993 Negative_regulation TNF PAM 24205328 2876003 Negative_regulation TNF PAM 24312681 2890708 Negative_regulation TNF PARN 18282094 3040856 Negative_regulation TNF PC 18560532 793024 Negative_regulation TNF PCSK2 20587063 402697 Negative_regulation TNF PDAP1 22195011 2583750 Negative_regulation TNF PDE3B 23781214 878837 Negative_regulation TNF PDE4A 22830422 1866259 Negative_regulation TNF PDE4D 22830422 1866260 Negative_regulation TNF PDLIM7 16573838 33379 Negative_regulation TNF PDLIM7 16573838 33380 Negative_regulation TNF PDLIM7 16573838 33383 Negative_regulation TNF PDLIM7 16573838 33384 Negative_regulation TNF PDLIM7 16573838 33385 Negative_regulation TNF PDLIM7 16573838 33386 Negative_regulation TNF PDLIM7 16573838 33387 Negative_regulation TNF PDLIM7 16573838 33388 Negative_regulation TNF PDLIM7 18331642 1625042 Negative_regulation TNF PDLIM7 18331642 1625043 Negative_regulation TNF PDLIM7 18331642 1625044 Negative_regulation TNF PDLIM7 18331642 1625045 Negative_regulation TNF PDLIM7 18331642 1625047 Negative_regulation TNF PDLIM7 18331642 1625053 Negative_regulation TNF PDLIM7 24453421 1756806 Negative_regulation TNF PDLIM7 24832514 176869 Negative_regulation TNF PDLIM7 PMC1188257 2370120 Negative_regulation TNF PGC 23050972 89636 Negative_regulation TNF PGC 24898700 1483520 Negative_regulation TNF PGF 22778499 1750120 Negative_regulation TNF PI3 25332099 607576 Negative_regulation TNF PIK3CA 11879539 98621 Negative_regulation TNF PIK3CA 20011115 3045895 Negative_regulation TNF PIK3CA 21054880 508234 Negative_regulation TNF PIK3CA 22577260 88186 Negative_regulation TNF PIK3CA 23514422 1683625 Negative_regulation TNF PIK3CA 23921460 3217720 Negative_regulation TNF PIK3R1 11879539 98622 Negative_regulation TNF PIK3R1 20011115 3045896 Negative_regulation TNF PIK3R1 21054880 508235 Negative_regulation TNF PIK3R1 22577260 88187 Negative_regulation TNF PIK3R1 23514422 1683626 Negative_regulation TNF PIK3R1 23921460 3217721 Negative_regulation TNF PIM1 21949737 2556419 Negative_regulation TNF PLAU 24120085 1667184 Negative_regulation TNF PLAUR 8601593 1450657 Negative_regulation TNF PLD1 22257771 3160830 Negative_regulation TNF PLG 23423541 960826 Negative_regulation TNF PLG 24639953 865054 Negative_regulation TNF PLG 3137305 1580325 Negative_regulation TNF PLIN2 22427949 2610805 Negative_regulation TNF PLK1 20484576 1776839 Negative_regulation TNF PLK1 24205328 2876004 Negative_regulation TNF PMS1 23593410 2781149 Negative_regulation TNF PMS1 23593410 2781150 Negative_regulation TNF PMS1 23593410 2781151 Negative_regulation TNF PMS1 23593410 2781173 Negative_regulation TNF PMS1 23593410 2781203 Negative_regulation TNF PMS2 23593410 2781152 Negative_regulation TNF PMS2 23593410 2781153 Negative_regulation TNF PMS2 23593410 2781154 Negative_regulation TNF PMS2 23593410 2781174 Negative_regulation TNF PMS2 23593410 2781204 Negative_regulation TNF PNLIP 25610476 827665 Negative_regulation TNF POLDIP2 22069638 3182915 Negative_regulation TNF POLDIP2 22951730 1631367 Negative_regulation TNF POLG2 15289505 1533211 Negative_regulation TNF PPARA 18274631 3071751 Negative_regulation TNF PPARA 18645614 3074471 Negative_regulation TNF PPARA 20835345 1710236 Negative_regulation TNF PPARA 21687401 922045 Negative_regulation TNF PPARA 22043207 667932 Negative_regulation TNF PPARA 22131647 1749664 Negative_regulation TNF PPARA 22339770 1661054 Negative_regulation TNF PPARA 22537532 1662207 Negative_regulation TNF PPARA 22888436 1145758 Negative_regulation TNF PPARA 23056034 3075989 Negative_regulation TNF PPARA 24843689 1494573 Negative_regulation TNF PPARA PMC2118734 1605347 Negative_regulation TNF PPARG 22837927 1044244 Negative_regulation TNF PPP1R3A 24137309 843665 Negative_regulation TNF PPP1R3A 24137309 843669 Negative_regulation TNF PPP1R3A 24979747 2985665 Negative_regulation TNF PPP1R3A 25378990 1615505 Negative_regulation TNF PPP1R3A 25535474 1615574 Negative_regulation TNF PPP1R3A 25535474 1615575 Negative_regulation TNF PPP5C 25487878 3148035 Negative_regulation TNF PRDX1 25276170 96144 Negative_regulation TNF PRDX2 18504304 1551333 Negative_regulation TNF PRDX2 22768247 2660331 Negative_regulation TNF PRDX2 24039666 2844299 Negative_regulation TNF PRDX3 20716930 2222667 Negative_regulation TNF PRKAA1 23300870 2736906 Negative_regulation TNF PRKAA1 23525626 1490460 Negative_regulation TNF PRKAA1 25007068 1128301 Negative_regulation TNF PRKAA2 23300870 2736907 Negative_regulation TNF PRKAA2 23525626 1490461 Negative_regulation TNF PRKAA2 25007068 1128302 Negative_regulation TNF PRKAB1 23300870 2736908 Negative_regulation TNF PRKAB1 23525626 1490462 Negative_regulation TNF PRKAB1 25007068 1128303 Negative_regulation TNF PRKAB2 23300870 2736909 Negative_regulation TNF PRKAB2 23525626 1490463 Negative_regulation TNF PRKAB2 25007068 1128304 Negative_regulation TNF PRKACB 18568240 652497 Negative_regulation TNF PRKACB 18568240 652498 Negative_regulation TNF PRKACB 18568240 652553 Negative_regulation TNF PRKACB 19277197 2407756 Negative_regulation TNF PRKACB 22123833 1394055 Negative_regulation TNF PRKACB 22384111 2603896 Negative_regulation TNF PRKACB 22384111 2605795 Negative_regulation TNF PRKACB 22384111 2605796 Negative_regulation TNF PRKACB 22384111 2605855 Negative_regulation TNF PRKACB 23082076 23910 Negative_regulation TNF PRKACB 23091522 1717464 Negative_regulation TNF PRKACB 23551576 1480313 Negative_regulation TNF PRKACB 24701420 86701 Negative_regulation TNF PRKACG 18568240 652499 Negative_regulation TNF PRKACG 18568240 652500 Negative_regulation TNF PRKACG 18568240 652554 Negative_regulation TNF PRKACG 19277197 2407757 Negative_regulation TNF PRKACG 22123833 1394056 Negative_regulation TNF PRKACG 22384111 2603897 Negative_regulation TNF PRKACG 22384111 2605797 Negative_regulation TNF PRKACG 22384111 2605798 Negative_regulation TNF PRKACG 22384111 2605856 Negative_regulation TNF PRKACG 23082076 23911 Negative_regulation TNF PRKACG 23091522 1717465 Negative_regulation TNF PRKACG 23551576 1480314 Negative_regulation TNF PRKACG 24701420 86702 Negative_regulation TNF PRKAG1 23300870 2736910 Negative_regulation TNF PRKAG1 23525626 1490464 Negative_regulation TNF PRKAG1 25007068 1128305 Negative_regulation TNF PRKAG2 23300870 2736911 Negative_regulation TNF PRKAG2 23525626 1490465 Negative_regulation TNF PRKAG2 25007068 1128306 Negative_regulation TNF PRKAR1A 18568240 652501 Negative_regulation TNF PRKAR1A 18568240 652502 Negative_regulation TNF PRKAR1A 18568240 652555 Negative_regulation TNF PRKAR1A 19277197 2407758 Negative_regulation TNF PRKAR1A 22123833 1394057 Negative_regulation TNF PRKAR1A 22384111 2603898 Negative_regulation TNF PRKAR1A 22384111 2605799 Negative_regulation TNF PRKAR1A 22384111 2605800 Negative_regulation TNF PRKAR1A 22384111 2605857 Negative_regulation TNF PRKAR1A 23082076 23912 Negative_regulation TNF PRKAR1A 23091522 1717466 Negative_regulation TNF PRKAR1A 23551576 1480315 Negative_regulation TNF PRKAR1A 24701420 86703 Negative_regulation TNF PRKAR1B 18568240 652503 Negative_regulation TNF PRKAR1B 18568240 652504 Negative_regulation TNF PRKAR1B 18568240 652556 Negative_regulation TNF PRKAR1B 19277197 2407759 Negative_regulation TNF PRKAR1B 22123833 1394058 Negative_regulation TNF PRKAR1B 22384111 2603899 Negative_regulation TNF PRKAR1B 22384111 2605801 Negative_regulation TNF PRKAR1B 22384111 2605802 Negative_regulation TNF PRKAR1B 22384111 2605858 Negative_regulation TNF PRKAR1B 23082076 23913 Negative_regulation TNF PRKAR1B 23091522 1717467 Negative_regulation TNF PRKAR1B 23551576 1480316 Negative_regulation TNF PRKAR1B 24701420 86704 Negative_regulation TNF PRKAR2A 18568240 652505 Negative_regulation TNF PRKAR2A 18568240 652506 Negative_regulation TNF PRKAR2A 18568240 652557 Negative_regulation TNF PRKAR2A 19277197 2407760 Negative_regulation TNF PRKAR2A 22123833 1394059 Negative_regulation TNF PRKAR2A 22384111 2603900 Negative_regulation TNF PRKAR2A 22384111 2605803 Negative_regulation TNF PRKAR2A 22384111 2605804 Negative_regulation TNF PRKAR2A 22384111 2605859 Negative_regulation TNF PRKAR2A 23082076 23914 Negative_regulation TNF PRKAR2A 23091522 1717468 Negative_regulation TNF PRKAR2A 23551576 1480317 Negative_regulation TNF PRKAR2A 24701420 86705 Negative_regulation TNF PRKAR2B 18568240 652507 Negative_regulation TNF PRKAR2B 18568240 652508 Negative_regulation TNF PRKAR2B 18568240 652558 Negative_regulation TNF PRKAR2B 19277197 2407761 Negative_regulation TNF PRKAR2B 22123833 1394060 Negative_regulation TNF PRKAR2B 22384111 2603901 Negative_regulation TNF PRKAR2B 22384111 2605805 Negative_regulation TNF PRKAR2B 22384111 2605806 Negative_regulation TNF PRKAR2B 22384111 2605860 Negative_regulation TNF PRKAR2B 23082076 23915 Negative_regulation TNF PRKAR2B 23091522 1717469 Negative_regulation TNF PRKAR2B 23551576 1480318 Negative_regulation TNF PRKAR2B 24701420 86706 Negative_regulation TNF PRNP 23133614 2713198 Negative_regulation TNF PROS1 10231008 1049535 Negative_regulation TNF PSMA1 24699819 3066579 Negative_regulation TNF PSMA2 24699819 3066580 Negative_regulation TNF PSMA5 24699819 3066581 Negative_regulation TNF PSMA7 24699819 3066582 Negative_regulation TNF PSMB1 24699819 3066583 Negative_regulation TNF PSMB10 24699819 3066584 Negative_regulation TNF PSMB2 24699819 3066585 Negative_regulation TNF PSMB3 24699819 3066586 Negative_regulation TNF PSMB6 24699819 3066587 Negative_regulation TNF PSMB7 24699819 3066588 Negative_regulation TNF PSMB8 24699819 3066589 Negative_regulation TNF PSMB9 24699819 3066590 Negative_regulation TNF PSMC1 24699819 3066591 Negative_regulation TNF PSMC2 24699819 3066592 Negative_regulation TNF PSMC3 24699819 3066593 Negative_regulation TNF PSMC4 24699819 3066594 Negative_regulation TNF PSMC5 24699819 3066595 Negative_regulation TNF PSMC6 24699819 3066596 Negative_regulation TNF PSMD1 24699819 3066597 Negative_regulation TNF PSMD10 24699819 3066598 Negative_regulation TNF PSMD12 24699819 3066599 Negative_regulation TNF PSMD13 24699819 3066600 Negative_regulation TNF PSMD2 24699819 3066601 Negative_regulation TNF PSMD4 24699819 3066602 Negative_regulation TNF PSMD5 24699819 3066603 Negative_regulation TNF PSMD6 24699819 3066604 Negative_regulation TNF PSMD7 24699819 3066605 Negative_regulation TNF PSMD8 24699819 3066606 Negative_regulation TNF PSMD9 24699819 3066607 Negative_regulation TNF PSME1 24699819 3066608 Negative_regulation TNF PSME2 24699819 3066609 Negative_regulation TNF PSME3 24699819 3066610 Negative_regulation TNF PSMF1 24699819 3066611 Negative_regulation TNF PTBP1 12437786 1733972 Negative_regulation TNF PTBP1 12566416 1525876 Negative_regulation TNF PTBP1 15197227 1532935 Negative_regulation TNF PTBP1 18195069 1548411 Negative_regulation TNF PTBP1 18817542 352442 Negative_regulation TNF PTBP1 21102427 1719823 Negative_regulation TNF PTBP1 22279513 2219172 Negative_regulation TNF PTBP2 12437786 1733969 Negative_regulation TNF PTBP2 12566416 1525873 Negative_regulation TNF PTBP2 15197227 1532932 Negative_regulation TNF PTBP2 18195069 1548408 Negative_regulation TNF PTBP2 18817542 352437 Negative_regulation TNF PTBP2 21102427 1719820 Negative_regulation TNF PTBP2 22279513 2219169 Negative_regulation TNF PTEN 21627859 623738 Negative_regulation TNF PTGS2 11375052 224812 Negative_regulation TNF PTGS2 19931610 452513 Negative_regulation TNF PTGS2 20862387 631931 Negative_regulation TNF PTGS2 22359588 2597941 Negative_regulation TNF PTGS2 22474587 2009409 Negative_regulation TNF PTGS2 23451048 2757340 Negative_regulation TNF PTGS2 23935691 822209 Negative_regulation TNF PTGS2 24386004 825047 Negative_regulation TNF PTGS2 24499158 2113949 Negative_regulation TNF PTGS2 25314304 3015599 Negative_regulation TNF PTPN22 23433117 220396 Negative_regulation TNF PTPN7 24265715 2885030 Negative_regulation TNF PTPN7 24265715 2885031 Negative_regulation TNF PTPN7 24265715 2885058 Negative_regulation TNF PTPRC 18478117 2388657 Negative_regulation TNF PTX3 18568240 652509 Negative_regulation TNF PTX3 18568240 652559 Negative_regulation TNF PTX3 19430535 2416366 Negative_regulation TNF PTX3 20177491 1046995 Negative_regulation TNF PTX3 21167055 1626280 Negative_regulation TNF PTX3 21167055 1626281 Negative_regulation TNF PTX3 22319522 832514 Negative_regulation TNF PTX3 23593327 2780664 Negative_regulation TNF PTX3 24192345 295260 Negative_regulation TNF PTX3 24959559 1154638 Negative_regulation TNF PTX3 8936451 1030867 Negative_regulation TNF PTX4 18568240 652496 Negative_regulation TNF PTX4 18568240 652552 Negative_regulation TNF PTX4 19430535 2416365 Negative_regulation TNF PTX4 20177491 1046994 Negative_regulation TNF PTX4 21167055 1626278 Negative_regulation TNF PTX4 21167055 1626279 Negative_regulation TNF PTX4 22319522 832513 Negative_regulation TNF PTX4 23593327 2780663 Negative_regulation TNF PTX4 24192345 295259 Negative_regulation TNF PTX4 24959559 1154637 Negative_regulation TNF PTX4 8936451 1030866 Negative_regulation TNF RABEPK 15813981 1624698 Negative_regulation TNF RASSF1 22577551 1831223 Negative_regulation TNF RASSF1 23915220 1869414 Negative_regulation TNF RASSF1 24327924 1831663 Negative_regulation TNF RASSF1 24327924 1831666 Negative_regulation TNF RASSF1 24776599 514524 Negative_regulation TNF RB1 23717116 1614121 Negative_regulation TNF RB1 23717137 1614267 Negative_regulation TNF RB1 25206809 2005938 Negative_regulation TNF RB1 25206809 2005942 Negative_regulation TNF RB1 25206809 2005945 Negative_regulation TNF RBBP4 20419126 2447047 Negative_regulation TNF RBBP7 20419126 2447048 Negative_regulation TNF RBL2 23717114 1614114 Negative_regulation TNF RBM10 23675440 2792967 Negative_regulation TNF RBM5 20652022 2456173 Negative_regulation TNF RBMS1 22465950 14659 Negative_regulation TNF RBP4 21808585 1682043 Negative_regulation TNF RBPJ 22249448 1566860 Negative_regulation TNF RCAN1 19124655 1553299 Negative_regulation TNF RELA 11097212 702117 Negative_regulation TNF RELA 18822146 161149 Negative_regulation TNF RELA 18834508 583300 Negative_regulation TNF RELA 19257911 365627 Negative_regulation TNF RELA 22375551 1230313 Negative_regulation TNF RELA 22432004 2611479 Negative_regulation TNF RELA 23690819 637305 Negative_regulation TNF RELA 23976842 742709 Negative_regulation TNF RELA 24191131 1754984 Negative_regulation TNF RELA 24586568 2925503 Negative_regulation TNF RELA 24957606 2102191 Negative_regulation TNF RELA PMC4291901 541432 Negative_regulation TNF REM1 24367384 639388 Negative_regulation TNF RENBP 21499478 1722195 Negative_regulation TNF RETN 23710116 1753138 Negative_regulation TNF RICTOR 24516119 1574933 Negative_regulation TNF RIPK3 21921917 1987944 Negative_regulation TNF RIPK3 25136567 197163 Negative_regulation TNF RNF123 19262463 764084 Negative_regulation TNF RNF19A 17342245 810710 Negative_regulation TNF RNF19A 20011115 3045903 Negative_regulation TNF RNF19A 23277816 1710355 Negative_regulation TNF RNF19A 23549267 1105197 Negative_regulation TNF RNF19A 24982891 193530 Negative_regulation TNF RNGTT 25012519 297595 Negative_regulation TNF RNGTT 25012519 297596 Negative_regulation TNF RPE 23133491 816231 Negative_regulation TNF RPE 23133491 816232 Negative_regulation TNF RPE 23133491 816238 Negative_regulation TNF RPL17 21750671 3052228 Negative_regulation TNF RPL17 24690491 1667884 Negative_regulation TNF RPL17 25438012 2234108 Negative_regulation TNF RPL19 22074550 247899 Negative_regulation TNF RPL34 24989059 368513 Negative_regulation TNF RPL39 24989059 368514 Negative_regulation TNF RPS6KB1 24116273 204234 Negative_regulation TNF RTL1 23663457 3113640 Negative_regulation TNF RTL1 25409514 3028766 Negative_regulation TNF RTN4 23435238 3222295 Negative_regulation TNF RTN4 24967365 193104 Negative_regulation TNF S100A12 23638054 2787327 Negative_regulation TNF S100A12 23965627 1990867 Negative_regulation TNF S100A12 PMC4184146 2236333 Negative_regulation TNF S100A9 23133376 3059965 Negative_regulation TNF S100A9 PMC4184146 2236334 Negative_regulation TNF S1PR1 PMC4052545 2247017 Negative_regulation TNF SCN8A 16258197 1740207 Negative_regulation TNF SCN8A 22984582 2689223 Negative_regulation TNF SELE 22014750 211760 Negative_regulation TNF SELE 23533479 817796 Negative_regulation TNF SELE 23533479 817797 Negative_regulation TNF SELE 23770053 1498336 Negative_regulation TNF SERPINA4 20509975 256087 Negative_regulation TNF SERPINB6 15809354 1535343 Negative_regulation TNF SERPINB6 15809354 1535345 Negative_regulation TNF SERPINE1 22619730 1151096 Negative_regulation TNF SERPINE1 23717597 2798456 Negative_regulation TNF SERPINE1 24744780 1074063 Negative_regulation TNF SERPINE1 25110685 196160 Negative_regulation TNF SERPINE1 25133669 2998724 Negative_regulation TNF SERPINE1 25289075 845246 Negative_regulation TNF SERPINF1 18523656 1908070 Negative_regulation TNF SERPINF1 19247457 1908995 Negative_regulation TNF SERPINF1 19247457 1909002 Negative_regulation TNF SERPINF1 22570532 1224096 Negative_regulation TNF SERPINF1 25258680 1675222 Negative_regulation TNF SERPING1 23991040 2840611 Negative_regulation TNF SETBP1 22272213 813662 Negative_regulation TNF SETBP1 22272213 813670 Negative_regulation TNF SF1 21241498 788980 Negative_regulation TNF SFRP1 24339864 2891235 Negative_regulation TNF SFRP1 24339864 2891248 Negative_regulation TNF SFRP1 24339864 2891269 Negative_regulation TNF SFTPA2 22879717 88200 Negative_regulation TNF SFTPA2 24611014 3177127 Negative_regulation TNF SHBG 24058910 184117 Negative_regulation TNF SIGLEC9 24391502 3065874 Negative_regulation TNF SIL1 21286013 1635342 Negative_regulation TNF SIRT1 22069489 2569224 Negative_regulation TNF SIRT1 22069489 2569228 Negative_regulation TNF SIRT1 23805409 20463 Negative_regulation TNF SIRT1 24039666 2844486 Negative_regulation TNF SIRT1 24039666 2844493 Negative_regulation TNF SIRT1 25501750 3033756 Negative_regulation TNF SIRT2 24039666 2844485 Negative_regulation TNF SIRT2 24039666 2844492 Negative_regulation TNF SIRT3 24039666 2844487 Negative_regulation TNF SIRT3 24039666 2844494 Negative_regulation TNF SIRT4 24039666 2844488 Negative_regulation TNF SIRT4 24039666 2844495 Negative_regulation TNF SIRT5 24039666 2844489 Negative_regulation TNF SIRT5 24039666 2844496 Negative_regulation TNF SIRT6 19936064 2431678 Negative_regulation TNF SIRT6 24039666 2844490 Negative_regulation TNF SIRT6 24039666 2844497 Negative_regulation TNF SIRT7 24039666 2844491 Negative_regulation TNF SIRT7 24039666 2844498 Negative_regulation TNF SKP1 9467064 797613 Negative_regulation TNF SLAMF1 20672047 1747592 Negative_regulation TNF SLC1A2 24836816 2971327 Negative_regulation TNF SLC22A3 20051102 854919 Negative_regulation TNF SLC25A10 22723938 2655155 Negative_regulation TNF SLC25A3 22037734 1735158 Negative_regulation TNF SLC33A1 18500976 3108956 Negative_regulation TNF SLPI 10449524 1512269 Negative_regulation TNF SLPI 21356117 1626337 Negative_regulation TNF SMARCA2 24330807 1667455 Negative_regulation TNF SMARCA4 24330807 1667456 Negative_regulation TNF SMARCB1 24330807 1667457 Negative_regulation TNF SMARCC1 24330807 1667458 Negative_regulation TNF SMARCC2 24330807 1667459 Negative_regulation TNF SMARCD1 24330807 1667460 Negative_regulation TNF SMARCE1 24330807 1667461 Negative_regulation TNF SMPD1 23230083 1637637 Negative_regulation TNF SNAI2 23339680 3226548 Negative_regulation TNF SNAI2 23339680 3226549 Negative_regulation TNF SNORA73A 24260034 25031 Negative_regulation TNF SOCS1 22132325 1686779 Negative_regulation TNF SOCS1 23236370 2725992 Negative_regulation TNF SOCS3 19698101 362364 Negative_regulation TNF SOCS3 22500980 355779 Negative_regulation TNF SOD1 24381587 23154 Negative_regulation TNF SOD2 23078757 660368 Negative_regulation TNF SOD2 24381587 23155 Negative_regulation TNF SOD3 24381587 23156 Negative_regulation TNF SPAM1 11960552 276598 Negative_regulation TNF SPHK1 20498849 2451123 Negative_regulation TNF SPHK1 20498849 2451160 Negative_regulation TNF SPHK2 22654878 901073 Negative_regulation TNF SRL 17498286 274430 Negative_regulation TNF SRR 23853427 1754088 Negative_regulation TNF SST 23965627 1990868 Negative_regulation TNF SST 24280677 2244850 Negative_regulation TNF SST 24324897 1150654 Negative_regulation TNF SST 25530957 201946 Negative_regulation TNF SST 25530957 201948 Negative_regulation TNF ST3GAL4 16192669 1740119 Negative_regulation TNF STAT3 21552420 1057171 Negative_regulation TNF STAT3 22114683 2573411 Negative_regulation TNF STAT3 22174891 2582470 Negative_regulation TNF STAT3 22417709 125160 Negative_regulation TNF STAT3 22937006 2682689 Negative_regulation TNF STAT3 24101903 962360 Negative_regulation TNF STAT3 25092271 1087681 Negative_regulation TNF STAT3 25431115 3211265 Negative_regulation TNF STAT6 14638848 1529825 Negative_regulation TNF STAT6 14638848 1529826 Negative_regulation TNF STAT6 14638848 1529827 Negative_regulation TNF STAT6 14638848 1529828 Negative_regulation TNF STAT6 14638848 1529829 Negative_regulation TNF STAT6 14638848 1529863 Negative_regulation TNF STAT6 14638848 1529864 Negative_regulation TNF STAT6 14638848 1529877 Negative_regulation TNF STAT6 14638848 1529878 Negative_regulation TNF STAT6 14638848 1529879 Negative_regulation TNF STAT6 14638848 1529909 Negative_regulation TNF STAT6 14638848 1529913 Negative_regulation TNF STIM1 23272049 2729487 Negative_regulation TNF STK32C 24944768 2115566 Negative_regulation TNF STK32C 24944768 2115574 Negative_regulation TNF STMN4 25084093 2994025 Negative_regulation TNF SYK 22883599 292350 Negative_regulation TNF SYT1 12110141 99240 Negative_regulation TNF SYT1 22655058 2646738 Negative_regulation TNF SYT1 25211214 3069135 Negative_regulation TNF SYT1 25386181 915095 Negative_regulation TNF SYT10 25386181 915108 Negative_regulation TNF SYT11 25386181 915105 Negative_regulation TNF SYT12 25386181 915103 Negative_regulation TNF SYT13 25386181 915101 Negative_regulation TNF SYT14 25386181 915110 Negative_regulation TNF SYT15 25386181 915102 Negative_regulation TNF SYT16 25386181 915109 Negative_regulation TNF SYT17 25386181 915111 Negative_regulation TNF SYT2 25386181 915096 Negative_regulation TNF SYT3 25386181 915097 Negative_regulation TNF SYT4 25386181 915098 Negative_regulation TNF SYT5 25386181 915099 Negative_regulation TNF SYT6 25386181 915104 Negative_regulation TNF SYT7 25386181 915100 Negative_regulation TNF SYT8 25386181 915106 Negative_regulation TNF SYT9 25386181 915107 Negative_regulation TNF TAB1 24434512 570895 Negative_regulation TNF TAP2 22883599 292391 Negative_regulation TNF TAT 22582137 2112 Negative_regulation TNF TAT 23555964 2776286 Negative_regulation TNF TBCA 24250492 1149393 Negative_regulation TNF TBL1X 23549795 3233069 Negative_regulation TNF TBL1XR1 23155382 2716987 Negative_regulation TNF TBL1XR1 23549795 3233071 Negative_regulation TNF TBP 22247597 1490074 Negative_regulation TNF TBX2 17331607 1235063 Negative_regulation TNF TECR 22031828 2565224 Negative_regulation TNF TET1 19753301 2426488 Negative_regulation TNF TET2 19753301 2426486 Negative_regulation TNF TET3 19753301 2426487 Negative_regulation TNF TFPI PMC3332967 660999 Negative_regulation TNF TGFB1 3110354 1580012 Negative_regulation TNF TGFB1 3110354 1580014 Negative_regulation TNF TGFB1 7688028 1591539 Negative_regulation TNF TGM4 22291795 95033 Negative_regulation TNF TGM4 22291795 95040 Negative_regulation TNF THBD 19450727 1770213 Negative_regulation TNF THBS2 24376766 2902005 Negative_regulation TNF TIA1 24658545 2937813 Negative_regulation TNF TIA1 PMC3273100 99531 Negative_regulation TNF TIMP1 11438041 98441 Negative_regulation TNF TIMP1 21912706 2371038 Negative_regulation TNF TIMP1 22460094 1735351 Negative_regulation TNF TIMP1 22558080 2624245 Negative_regulation TNF TIMP1 24066058 2850757 Negative_regulation TNF TIMP1 24212940 499192 Negative_regulation TNF TIMP1 25136613 197306 Negative_regulation TNF TIMP2 24970341 1668314 Negative_regulation TNF TIMP3 17324256 320016 Negative_regulation TNF TIMP3 19581416 710362 Negative_regulation TNF TIMP3 25013379 1063091 Negative_regulation TNF TIRAP 23305364 694095 Negative_regulation TNF TKTL1 21931534 2277147 Negative_regulation TNF TLR1 16061725 1536962 Negative_regulation TNF TLR1 17998391 1547756 Negative_regulation TNF TLR1 18195069 1548406 Negative_regulation TNF TLR1 18584038 3072550 Negative_regulation TNF TLR1 18584038 3072750 Negative_regulation TNF TLR1 19770272 1556326 Negative_regulation TNF TLR1 23787171 1666797 Negative_regulation TNF TLR1 25101057 881004 Negative_regulation TNF TLR10 16061725 1536970 Negative_regulation TNF TLR10 17998391 1547764 Negative_regulation TNF TLR10 18584038 3072558 Negative_regulation TNF TLR10 18584038 3072758 Negative_regulation TNF TLR10 19770272 1556334 Negative_regulation TNF TLR10 23787171 1666805 Negative_regulation TNF TLR10 25101057 881012 Negative_regulation TNF TLR2 16061725 1536963 Negative_regulation TNF TLR2 17998391 1547757 Negative_regulation TNF TLR2 18195069 1548407 Negative_regulation TNF TLR2 18584038 3072551 Negative_regulation TNF TLR2 18584038 3072751 Negative_regulation TNF TLR2 19770272 1556327 Negative_regulation TNF TLR2 21049294 665222 Negative_regulation TNF TLR2 21483834 2512373 Negative_regulation TNF TLR2 21611196 2523843 Negative_regulation TNF TLR2 22701116 901636 Negative_regulation TNF TLR2 23176969 3179397 Negative_regulation TNF TLR2 23787171 1666798 Negative_regulation TNF TLR2 23852085 18074 Negative_regulation TNF TLR2 24391778 2904462 Negative_regulation TNF TLR2 24886142 368277 Negative_regulation TNF TLR2 25101057 881005 Negative_regulation TNF TLR3 15197227 1532929 Negative_regulation TNF TLR3 16061725 1536964 Negative_regulation TNF TLR3 17998391 1547758 Negative_regulation TNF TLR3 18584038 3072552 Negative_regulation TNF TLR3 18584038 3072752 Negative_regulation TNF TLR3 19122812 2404043 Negative_regulation TNF TLR3 19770272 1556328 Negative_regulation TNF TLR3 22131998 1703205 Negative_regulation TNF TLR3 23787171 1666799 Negative_regulation TNF TLR3 25101057 881006 Negative_regulation TNF TLR3 25206644 2005451 Negative_regulation TNF TLR4 15197227 1532930 Negative_regulation TNF TLR4 16061725 1536965 Negative_regulation TNF TLR4 16322770 3039073 Negative_regulation TNF TLR4 17242961 810088 Negative_regulation TNF TLR4 17998391 1547759 Negative_regulation TNF TLR4 18498620 352179 Negative_regulation TNF TLR4 18584038 3072553 Negative_regulation TNF TLR4 18584038 3072753 Negative_regulation TNF TLR4 19770272 1556329 Negative_regulation TNF TLR4 21483834 2512374 Negative_regulation TNF TLR4 21556316 1078176 Negative_regulation TNF TLR4 22485093 956798 Negative_regulation TNF TLR4 22685622 2224296 Negative_regulation TNF TLR4 22951730 1631214 Negative_regulation TNF TLR4 22951730 1631368 Negative_regulation TNF TLR4 23056598 2702360 Negative_regulation TNF TLR4 23108585 1022067 Negative_regulation TNF TLR4 23429360 838537 Negative_regulation TNF TLR4 23555964 2776287 Negative_regulation TNF TLR4 23645013 17638 Negative_regulation TNF TLR4 23762102 819851 Negative_regulation TNF TLR4 23787171 1666800 Negative_regulation TNF TLR4 24345260 809488 Negative_regulation TNF TLR4 24550893 926351 Negative_regulation TNF TLR4 24595131 2930814 Negative_regulation TNF TLR4 25101057 881007 Negative_regulation TNF TLR4 25120616 844877 Negative_regulation TNF TLR5 16061725 1536966 Negative_regulation TNF TLR5 17998391 1547760 Negative_regulation TNF TLR5 18584038 3072554 Negative_regulation TNF TLR5 18584038 3072754 Negative_regulation TNF TLR5 19461888 3043876 Negative_regulation TNF TLR5 19770272 1556330 Negative_regulation TNF TLR5 21483834 2512375 Negative_regulation TNF TLR5 23787171 1666801 Negative_regulation TNF TLR5 25101057 881008 Negative_regulation TNF TLR6 16061725 1536971 Negative_regulation TNF TLR6 17998391 1547765 Negative_regulation TNF TLR6 18584038 3072559 Negative_regulation TNF TLR6 18584038 3072759 Negative_regulation TNF TLR6 19770272 1556335 Negative_regulation TNF TLR6 23787171 1666806 Negative_regulation TNF TLR6 25101057 881013 Negative_regulation TNF TLR7 16061725 1536967 Negative_regulation TNF TLR7 17998391 1547761 Negative_regulation TNF TLR7 18584038 3072555 Negative_regulation TNF TLR7 18584038 3072755 Negative_regulation TNF TLR7 19770272 1556331 Negative_regulation TNF TLR7 21115688 1562043 Negative_regulation TNF TLR7 21115688 1562055 Negative_regulation TNF TLR7 23787171 1666802 Negative_regulation TNF TLR7 25101057 881009 Negative_regulation TNF TLR8 16061725 1536968 Negative_regulation TNF TLR8 17998391 1547762 Negative_regulation TNF TLR8 18584038 3072556 Negative_regulation TNF TLR8 18584038 3072756 Negative_regulation TNF TLR8 19770272 1556332 Negative_regulation TNF TLR8 23787171 1666803 Negative_regulation TNF TLR8 25101057 881010 Negative_regulation TNF TLR9 15197227 1532931 Negative_regulation TNF TLR9 16061725 1536969 Negative_regulation TNF TLR9 17998391 1547763 Negative_regulation TNF TLR9 18584038 3072557 Negative_regulation TNF TLR9 18584038 3072757 Negative_regulation TNF TLR9 19515231 3109638 Negative_regulation TNF TLR9 19770272 1556333 Negative_regulation TNF TLR9 21115688 1562044 Negative_regulation TNF TLR9 23787171 1666804 Negative_regulation TNF TLR9 24722226 3066649 Negative_regulation TNF TLR9 25101057 881011 Negative_regulation TNF TNFAIP1 23607009 515499 Negative_regulation TNF TNFAIP3 19262463 764082 Negative_regulation TNF TNFAIP3 22958952 1920499 Negative_regulation TNF TNFAIP6 22359280 778201 Negative_regulation TNF TNFAIP6 24979372 2985647 Negative_regulation TNF TNFAIP6 25088370 1668434 Negative_regulation TNF TNFAIP6 25562599 3037244 Negative_regulation TNF TNFRSF1A 16385659 3230829 Negative_regulation TNF TNFRSF1A 16385659 3230838 Negative_regulation TNF TNFRSF1A 21801431 123339 Negative_regulation TNF TNFRSF1A 22666474 2648197 Negative_regulation TNF TNFRSF1A 23341882 2741326 Negative_regulation TNF TNFRSF1B 17971210 3108464 Negative_regulation TNF TNFRSF1B 18171484 1655207 Negative_regulation TNF TNFRSF1B 18360618 3176735 Negative_regulation TNF TNFRSF1B 18922887 84787 Negative_regulation TNF TNFRSF1B 19225537 1719189 Negative_regulation TNF TNFRSF1B 19232066 112919 Negative_regulation TNF TNFRSF1B 19707339 175519 Negative_regulation TNF TNFRSF1B 19794002 729291 Negative_regulation TNF TNFRSF1B 20016797 2234789 Negative_regulation TNF TNFRSF1B 20711219 10877 Negative_regulation TNF TNFRSF1B 20712883 2236007 Negative_regulation TNF TNFRSF1B 20939923 2112694 Negative_regulation TNF TNFRSF1B 21436970 629847 Negative_regulation TNF TNFRSF1B 21436974 629867 Negative_regulation TNF TNFRSF1B 21494547 2512972 Negative_regulation TNF TNFRSF1B 21572800 1043970 Negative_regulation TNF TNFRSF1B 21909945 3126124 Negative_regulation TNF TNFRSF1B 21949655 3053560 Negative_regulation TNF TNFRSF1B 21949655 3053587 Negative_regulation TNF TNFRSF1B 22074550 247900 Negative_regulation TNF TNFRSF1B 22192852 124467 Negative_regulation TNF TNFRSF1B 22685633 1080055 Negative_regulation TNF TNFRSF1B 22761866 2658900 Negative_regulation TNF TNFRSF1B 22761866 2658901 Negative_regulation TNF TNFRSF1B 22761866 2658902 Negative_regulation TNF TNFRSF1B 22802951 2663769 Negative_regulation TNF TNFRSF1B 22802951 2663770 Negative_regulation TNF TNFRSF1B 22937436 515822 Negative_regulation TNF TNFRSF1B 22937439 515823 Negative_regulation TNF TNFRSF1B 23056066 95290 Negative_regulation TNF TNFRSF1B 23148339 412755 Negative_regulation TNF TNFRSF1B 23205324 696983 Negative_regulation TNF TNFRSF1B 23403473 842966 Negative_regulation TNF TNFRSF1B 23515267 629877 Negative_regulation TNF TNFRSF1B 23606968 1145857 Negative_regulation TNF TNFRSF1B 23606968 1145862 Negative_regulation TNF TNFRSF1B 23869169 2234832 Negative_regulation TNF TNFRSF1B 23980097 1573536 Negative_regulation TNF TNFRSF1B 23990845 822662 Negative_regulation TNF TNFRSF1B 24151518 638742 Negative_regulation TNF TNFRSF1B 24151520 638775 Negative_regulation TNF TNFRSF1B 24191219 515832 Negative_regulation TNF TNFRSF1B 24228147 1710365 Negative_regulation TNF TNFRSF1B 24288431 737709 Negative_regulation TNF TNFRSF1B 24312102 910107 Negative_regulation TNF TNFRSF1B 24403823 742891 Negative_regulation TNF TNFRSF1B 24453423 1756968 Negative_regulation TNF TNFRSF1B 24492505 1046502 Negative_regulation TNF TNFRSF1B 24665368 1151042 Negative_regulation TNF TNFRSF1B 24665368 1151043 Negative_regulation TNF TNFRSF1B 24695748 2948354 Negative_regulation TNF TNFRSF1B 24707429 515833 Negative_regulation TNF TNFRSF1B 24802997 2286276 Negative_regulation TNF TNFRSF1B 24803742 1758422 Negative_regulation TNF TNFRSF1B 24860653 847819 Negative_regulation TNF TNFRSF1B 25045210 1760186 Negative_regulation TNF TNFRSF1B 25071247 1044087 Negative_regulation TNF TNFRSF1B 25260027 3010722 Negative_regulation TNF TNFRSF1B 25260027 3010723 Negative_regulation TNF TNFRSF1B 25260027 3010726 Negative_regulation TNF TNFRSF1B 25324981 3092401 Negative_regulation TNF TNFRSF1B 25384035 3024616 Negative_regulation TNF TNFRSF1B 25501574 3033647 Negative_regulation TNF TNFRSF1B 25598884 1710397 Negative_regulation TNF TNFRSF1B 25624856 96191 Negative_regulation TNF TNFRSF1B 8691130 1598113 Negative_regulation TNF TNFRSF1B PMC2750202 450206 Negative_regulation TNF TNFRSF1B PMC4190932 2236355 Negative_regulation TNF TNFRSF4 14568982 1529213 Negative_regulation TNF TNFRSF4 22315115 623300 Negative_regulation TNF TNFRSF6B 22648407 1203404 Negative_regulation TNF TNFRSF6B 22648407 1203462 Negative_regulation TNF TNFRSF6B 22672288 355947 Negative_regulation TNF TNFRSF9 21747409 1041753 Negative_regulation TNF TNFRSF9 23437083 2755513 Negative_regulation TNF TNFRSF9 23437083 2755514 Negative_regulation TNF TNFSF4 22315115 623301 Negative_regulation TNF TRAF1 19966777 1960878 Negative_regulation TNF TRAF6 18759964 111131 Negative_regulation TNF TRAF6 22496647 3056087 Negative_regulation TNF TRAF6 24939082 1087410 Negative_regulation TNF TRD 19309495 3226017 Negative_regulation TNF TREM1 25505454 927446 Negative_regulation TNF TRIM21 23737876 843222 Negative_regulation TNF TRIM27 22829933 2667965 Negative_regulation TNF TSN 21232147 508364 Negative_regulation TNF TUBB4B 25157248 913822 Negative_regulation TNF TWIST1 16420668 996861 Negative_regulation TNF TWIST1 22891766 245150 Negative_regulation TNF TXN 18475455 1743792 Negative_regulation TNF TXNRD2 22648407 1203405 Negative_regulation TNF TXNRD2 22648407 1203463 Negative_regulation TNF UBAC1 19262463 764085 Negative_regulation TNF UBE2N 20613989 2454653 Negative_regulation TNF UCN 23874274 921885 Negative_regulation TNF UCN 25540945 1654245 Negative_regulation TNF UCN 25540945 1654248 Negative_regulation TNF UCN2 25540945 1654246 Negative_regulation TNF UCP2 22348126 2596986 Negative_regulation TNF UGCG 22984532 2688715 Negative_regulation TNF UPF1 18282094 3040858 Negative_regulation TNF UPF2 18282094 3040851 Negative_regulation TNF UPF3B 18282094 3040853 Negative_regulation TNF USP12 25071782 913472 Negative_regulation TNF VASP 25051011 2991151 Negative_regulation TNF VCAM1 21808585 1682041 Negative_regulation TNF VDR 24474104 85245 Negative_regulation TNF VEGFA 17718922 3108336 Negative_regulation TNF VIMP 23634235 2225809 Negative_regulation TNF VIP 14680506 99973 Negative_regulation TNF VIP 14680506 99982 Negative_regulation TNF VIP 15899028 102731 Negative_regulation TNF VIP 15899028 102735 Negative_regulation TNF VIP 15899059 103830 Negative_regulation TNF VIP 21477377 3112073 Negative_regulation TNF VIP 22126441 34859 Negative_regulation TNF VIP 22328918 2595661 Negative_regulation TNF VIP 22328918 2595662 Negative_regulation TNF VIP 22328918 2595665 Negative_regulation TNF WAS 22563255 1714093 Negative_regulation TNF WAS 22563255 1714095 Negative_regulation TNF WAS 23028423 2690500 Negative_regulation TNF WAS 24009860 203980 Negative_regulation TNF WAS 24009860 204001 Negative_regulation TNF WNK1 21573233 2523018 Negative_regulation TNF WNK1 23409033 2753305 Negative_regulation TNF WNT1 24286133 130236 Negative_regulation TNF WNT11 24286133 130237 Negative_regulation TNF WNT16 24286133 130242 Negative_regulation TNF WNT2 24286133 130238 Negative_regulation TNF WNT3 24286133 130239 Negative_regulation TNF WNT3A 24663056 1125497 Negative_regulation TNF WNT3A 24971753 2985086 Negative_regulation TNF WNT4 24286133 130240 Negative_regulation TNF WNT6 24286133 130241 Negative_regulation TNF WWP1 23799152 2807439 Negative_regulation TNF WWP1 23799152 2807464 Negative_regulation TNF XIAP 25100434 2118889 Negative_regulation TNF XRN1 18282094 3040855 Negative_regulation TNF XRN2 18282094 3040849 Negative_regulation TNF ZC3H12A 21115689 1562107 Negative_regulation TNF ZC3H12A 23185455 2721081 Negative_regulation TNF ZFP36 14638848 1529830 Negative_regulation TNF ZFP36 14638848 1529831 Negative_regulation TNF ZFP36 14638848 1529880 Negative_regulation TNF ZFP36 14638848 1529893 Negative_regulation TNF ZFP36 14638848 1529914 Negative_regulation TNF ZFP36 15535838 101909 Negative_regulation TNF ZFP36 18953406 2399142 Negative_regulation TNF ZFP36 20221403 2442717 Negative_regulation TNF ZFP36 23468959 2760286 Negative_regulation TNF ZFP36 23468959 2760290 Negative_regulation TNF ZFP36 23468959 2760300 Negative_regulation TNF ZFP36 24069363 2853116 Negative_regulation TNF ZFP36 24753411 2100536 Negative_regulation TNF ZFYVE9 23435238 3222296 Negative_regulation TNF ZGLP1 23862164 1495347 Negative_regulation TNF ZNF823 20105294 1696589 Negative_regulation TNFAIP1 ID1 18315846 234227 Negative_regulation TNFRSF10A TNFSF10 15007095 1531845 Negative_regulation TNFRSF10B MUC16 24690311 272552 Negative_regulation TNFRSF10B OSR1 24931004 1681309 Negative_regulation TNFRSF10D TNFSF10 24324958 185709 Negative_regulation TNFRSF11B TGM2 24265865 206048 Negative_regulation TNFRSF11B TGM2 24265865 206076 Negative_regulation TNFRSF11B TNF 17963332 3231323 Negative_regulation TNFRSF11B TNF 22611381 23028 Negative_regulation TNFRSF11B TNFSF10 23476694 817454 Negative_regulation TNFRSF1A TNF 18096615 2032379 Negative_regulation TNFRSF1A TNF 18822146 161146 Negative_regulation TNFRSF1A TNF 21754991 2535247 Negative_regulation TNFRSF1A TNF 21801431 123340 Negative_regulation TNFRSF1A TNF 22666474 2648198 Negative_regulation TNFRSF1A TNF 24069158 2851639 Negative_regulation TNFRSF1A TNF 24475180 2915169 Negative_regulation TNFRSF1A TNF 25242872 1762314 Negative_regulation TNFRSF1A TNF 8595164 445326 Negative_regulation TNFRSF1B TNF 23205324 696984 Negative_regulation TNFRSF6B TNF 22672288 355948 Negative_regulation TNFRSF6B TNFSF10 24204567 2873067 Negative_regulation TNFSF10 AKT1 22159760 2170477 Negative_regulation TNFSF10 AKT1 22159760 2170488 Negative_regulation TNFSF10 AKT1 23091403 3129159 Negative_regulation TNFSF10 AKT2 22159760 2170478 Negative_regulation TNFSF10 AKT2 22159760 2170489 Negative_regulation TNFSF10 AKT2 23091403 3129160 Negative_regulation TNFSF10 AKT3 22159760 2170479 Negative_regulation TNFSF10 AKT3 22159760 2170490 Negative_regulation TNFSF10 AKT3 23091403 3129161 Negative_regulation TNFSF10 BIRC2 18606850 1353464 Negative_regulation TNFSF10 BIRC2 24633224 2934763 Negative_regulation TNFSF10 BUD13 16709253 3107261 Negative_regulation TNFSF10 BUD31 16709253 3107262 Negative_regulation TNFSF10 CASP1 10725337 1256827 Negative_regulation TNFSF10 CASP1 20661477 2456830 Negative_regulation TNFSF10 CASP1 24577084 572485 Negative_regulation TNFSF10 CASP10 10725337 1256828 Negative_regulation TNFSF10 CASP10 20661477 2456831 Negative_regulation TNFSF10 CASP10 24577084 572486 Negative_regulation TNFSF10 CASP12 10725337 1256838 Negative_regulation TNFSF10 CASP12 20661477 2456841 Negative_regulation TNFSF10 CASP12 24577084 572496 Negative_regulation TNFSF10 CASP14 10725337 1256829 Negative_regulation TNFSF10 CASP14 20661477 2456832 Negative_regulation TNFSF10 CASP14 24577084 572487 Negative_regulation TNFSF10 CASP16 10725337 1256839 Negative_regulation TNFSF10 CASP16 20661477 2456842 Negative_regulation TNFSF10 CASP16 24577084 572497 Negative_regulation TNFSF10 CASP2 10725337 1256830 Negative_regulation TNFSF10 CASP2 20661477 2456833 Negative_regulation TNFSF10 CASP2 24577084 572488 Negative_regulation TNFSF10 CASP3 10725337 1256831 Negative_regulation TNFSF10 CASP3 20661477 2456834 Negative_regulation TNFSF10 CASP3 24577084 572489 Negative_regulation TNFSF10 CASP4 10725337 1256832 Negative_regulation TNFSF10 CASP4 20661477 2456835 Negative_regulation TNFSF10 CASP4 24577084 572490 Negative_regulation TNFSF10 CASP5 10725337 1256833 Negative_regulation TNFSF10 CASP5 20661477 2456836 Negative_regulation TNFSF10 CASP5 24577084 572491 Negative_regulation TNFSF10 CASP6 10725337 1256834 Negative_regulation TNFSF10 CASP6 20661477 2456837 Negative_regulation TNFSF10 CASP6 24577084 572492 Negative_regulation TNFSF10 CASP7 10725337 1256835 Negative_regulation TNFSF10 CASP7 20661477 2456838 Negative_regulation TNFSF10 CASP7 24577084 572493 Negative_regulation TNFSF10 CASP8 10725337 1256836 Negative_regulation TNFSF10 CASP8 20416058 1854450 Negative_regulation TNFSF10 CASP8 20661477 2456839 Negative_regulation TNFSF10 CASP8 24577084 572494 Negative_regulation TNFSF10 CASP9 10725337 1256837 Negative_regulation TNFSF10 CASP9 20661477 2456840 Negative_regulation TNFSF10 CASP9 24577084 572495 Negative_regulation TNFSF10 CCND1 21179458 2488025 Negative_regulation TNFSF10 CD47 24030154 566110 Negative_regulation TNFSF10 CFLAR 25257790 1731035 Negative_regulation TNFSF10 CSF2 10209050 1511634 Negative_regulation TNFSF10 CXCR4 19390584 1746576 Negative_regulation TNFSF10 DNMT1 21108789 1860316 Negative_regulation TNFSF10 FADD 17916240 1645792 Negative_regulation TNFSF10 FADD 21209944 2492511 Negative_regulation TNFSF10 FADD 21264287 2495210 Negative_regulation TNFSF10 FOXO1 20604938 329347 Negative_regulation TNFSF10 FOXO3 20604938 329348 Negative_regulation TNFSF10 FOXO4 20604938 329349 Negative_regulation TNFSF10 FOXO6 20604938 329346 Negative_regulation TNFSF10 HDAC1 16930472 249680 Negative_regulation TNFSF10 HDAC1 19547714 1671115 Negative_regulation TNFSF10 HDAC1 21931726 2554255 Negative_regulation TNFSF10 HDAC1 25054063 1623602 Negative_regulation TNFSF10 HDAC2 16930472 249681 Negative_regulation TNFSF10 HDAC2 19547714 1671116 Negative_regulation TNFSF10 HDAC2 21931726 2554256 Negative_regulation TNFSF10 HDAC2 25054063 1623603 Negative_regulation TNFSF10 HLA-DRB1 20087343 434318 Negative_regulation TNFSF10 HRAS 23470485 2182445 Negative_regulation TNFSF10 IL10 10209050 1511635 Negative_regulation TNFSF10 IL12A 11257133 1519063 Negative_regulation TNFSF10 IL12B 11257133 1519064 Negative_regulation TNFSF10 IL15 10209050 1511636 Negative_regulation TNFSF10 IL1A 10209050 1511637 Negative_regulation TNFSF10 IL3 10209050 1511638 Negative_regulation TNFSF10 IL6 10209050 1511639 Negative_regulation TNFSF10 IL8 23028975 2694052 Negative_regulation TNFSF10 IRF1 19404407 2415731 Negative_regulation TNFSF10 IRF1 19404407 2415764 Negative_regulation TNFSF10 IRF3 21829705 2542477 Negative_regulation TNFSF10 IRF3 21829705 2542481 Negative_regulation TNFSF10 IRF7 19404407 2415732 Negative_regulation TNFSF10 KRAS 23470485 2182446 Negative_regulation TNFSF10 MADD 21915099 770791 Negative_regulation TNFSF10 MET 24748276 2956032 Negative_regulation TNFSF10 NA 23536831 2773131 Negative_regulation TNFSF10 NFATC1 21603612 2523450 Negative_regulation TNFSF10 NFATC1 21603612 2523451 Negative_regulation TNFSF10 NFATC1 21603612 2523458 Negative_regulation TNFSF10 NFATC1 21603612 2523464 Negative_regulation TNFSF10 NFATC1 21603612 2523471 Negative_regulation TNFSF10 NFATC1 21603612 2523501 Negative_regulation TNFSF10 NFATC2 21603612 2523452 Negative_regulation TNFSF10 NFATC2 21603612 2523502 Negative_regulation TNFSF10 NFATC2 25299780 578216 Negative_regulation TNFSF10 NRAS 23470485 2182447 Negative_regulation TNFSF10 PI3 21603612 2523443 Negative_regulation TNFSF10 PI3 21603612 2523459 Negative_regulation TNFSF10 PIK3C3 21603612 2523472 Negative_regulation TNFSF10 PIK3R4 21603612 2523473 Negative_regulation TNFSF10 PRDX2 25593641 206979 Negative_regulation TNFSF10 PTEN 21603612 2523460 Negative_regulation TNFSF10 PTEN 21603612 2523474 Negative_regulation TNFSF10 PTEN 24905916 2977430 Negative_regulation TNFSF10 RBBP4 16930472 249682 Negative_regulation TNFSF10 RBBP4 19547714 1671117 Negative_regulation TNFSF10 RBBP4 21931726 2554257 Negative_regulation TNFSF10 RBBP4 25054063 1623604 Negative_regulation TNFSF10 RBBP7 16930472 249683 Negative_regulation TNFSF10 RBBP7 19547714 1671118 Negative_regulation TNFSF10 RBBP7 21931726 2554258 Negative_regulation TNFSF10 RBBP7 25054063 1623605 Negative_regulation TNFSF10 SP1 21603612 2523449 Negative_regulation TNFSF10 SP1 21603612 2523470 Negative_regulation TNFSF10 SP1 21603612 2523480 Negative_regulation TNFSF10 TANK 18606850 1353463 Negative_regulation TNFSF10 TLR7 19686596 3118098 Negative_regulation TNFSF10 TLR9 22159760 2170494 Negative_regulation TNFSF10 TNFRSF10A 18504532 1644042 Negative_regulation TNFSF10 TNFRSF10C 21756247 3093029 Negative_regulation TNFSF10 TNFRSF10D 21264287 2495212 Negative_regulation TNFSF10 TNFRSF10D 21756247 3093030 Negative_regulation TNFSF10 TNFRSF11B 17341304 108149 Negative_regulation TNFSF10 TNFRSF6B 24204567 2873068 Negative_regulation TNFSF10 TNFRSF6B 24204567 2873069 Negative_regulation TNFSF10 TNFRSF6B 24204567 2873070 Negative_regulation TNFSF10 TP53 22892844 478739 Negative_regulation TNFSF10 TRAF6 22719861 2653278 Negative_regulation TNFSF10 XIAP 25257790 1731036 Negative_regulation TNFSF11 EPHB2 22567280 622912 Negative_regulation TNFSF11 EPHB2 24066131 2851163 Negative_regulation TNFSF11 TNF 17963332 3231326 Negative_regulation TNFSF11 TNF 21401926 121886 Negative_regulation TNFSF11 TNF 25228904 914172 Negative_regulation TNFSF11 TNFSF10 24040204 2846137 Negative_regulation TNFSF11 ZFP57 23569325 1571228 Negative_regulation TNFSF13 CCND1 19291294 252550 Negative_regulation TNFSF8 TNF 22514694 2619770 Negative_regulation TNMD MAP2K6 22031842 2565318 Negative_regulation TNNT2 CA2 23810896 1156991 Negative_regulation TNNT2 CAT 21600015 1697385 Negative_regulation TNNT2 CAT 21600015 1697396 Negative_regulation TNNT2 MBNL1 21109529 2059062 Negative_regulation TNNT2 PTPN22 21600015 1697386 Negative_regulation TNNT2 PTPN22 21600015 1697397 Negative_regulation TNNT2 SOD1 21600015 1697384 Negative_regulation TNNT2 SOD1 21600015 1697395 Negative_regulation TNPO1 TNF 7500047 1588521 Negative_regulation TNPO1 TNFSF10 24695582 2948272 Negative_regulation TOP1 STK39 23349762 2743103 Negative_regulation TOP1 STK39 23349762 2743104 Negative_regulation TOP1 STK39 23349762 2743121 Negative_regulation TP53 ABCA4 25516716 1063628 Negative_regulation TP53 ABCG2 19107196 2402692 Negative_regulation TP53 AGR2 23029506 2698495 Negative_regulation TP53 AGR2 25003466 2986996 Negative_regulation TP53 CCND1 10376986 414408 Negative_regulation TP53 CCND1 18665245 2214610 Negative_regulation TP53 CCND1 24962785 297231 Negative_regulation TP53 CDKN1C 21042410 2479576 Negative_regulation TP53 EPHB2 18847491 251676 Negative_regulation TP53 EPHB2 20421909 3176955 Negative_regulation TP53 EPHB2 20727231 466206 Negative_regulation TP53 EPHB2 25068118 3167133 Negative_regulation TP53 EPHB2 25068118 3167134 Negative_regulation TP53 FAS 18523653 2390327 Negative_regulation TP53 FAS 24904906 950065 Negative_regulation TP53 FOXO1 24757526 1491687 Negative_regulation TP53 JAG1 24098521 2858059 Negative_regulation TP53 LGALS7B 25277199 2203322 Negative_regulation TP53 MAP2K6 21411864 2175645 Negative_regulation TP53 MAP2K6 23085539 2181397 Negative_regulation TP53 MAP2K6 23638878 1868130 Negative_regulation TP53 MMP28 24690323 540108 Negative_regulation TP53 MMP7 24690323 540123 Negative_regulation TP53 OSR1 24931004 1681260 Negative_regulation TP53 OSR1 24931004 1681261 Negative_regulation TP53 PLAU 23864708 1816994 Negative_regulation TP53 PLAU 23864708 1816995 Negative_regulation TP53 PLAU 23864708 1817001 Negative_regulation TP53 PLAU 23864708 1817014 Negative_regulation TP53 S100B 18211683 1848466 Negative_regulation TP53 S100B 21445240 2509315 Negative_regulation TP53 S100B 21445240 2509316 Negative_regulation TP53 S100B 23189031 2121091 Negative_regulation TP53 S100B 23259641 1665802 Negative_regulation TP53 TNF 24172336 410771 Negative_regulation TP53 TNF 24283517 130119 Negative_regulation TP53 TP63 24823795 2100835 Negative_regulation TP63 ADORA2A 19487420 1554854 Negative_regulation TP63 AKT1 23545251 2182983 Negative_regulation TP63 AKT1 23545251 2182986 Negative_regulation TP63 AKT2 23545251 2182984 Negative_regulation TP63 AKT2 23545251 2182987 Negative_regulation TP63 AKT3 23545251 2182985 Negative_regulation TP63 AKT3 23545251 2182988 Negative_regulation TP63 APC 23509806 180541 Negative_regulation TP63 C1orf228 23071691 2703736 Negative_regulation TP63 CCDC88A 15728240 1534773 Negative_regulation TP63 CD14 15841259 810588 Negative_regulation TP63 DEFB103B 21809339 808405 Negative_regulation TP63 DKC1 16022731 1844841 Negative_regulation TP63 FGFR2 23545251 2182974 Negative_regulation TP63 HNRNPF 23675302 3061399 Negative_regulation TP63 HNRNPH1 23675302 3061400 Negative_regulation TP63 HSP90AA1 16022731 1844842 Negative_regulation TP63 IL10 22479554 2615931 Negative_regulation TP63 IL10 22479554 2615937 Negative_regulation TP63 IL12A 23071691 2703737 Negative_regulation TP63 IL12A 24098413 2856187 Negative_regulation TP63 IL12B 23071691 2703738 Negative_regulation TP63 IL12B 24098413 2856188 Negative_regulation TP63 IL17D 23593003 3060690 Negative_regulation TP63 IRF6 21918538 1630509 Negative_regulation TP63 IRF6 24940735 2980713 Negative_regulation TP63 IRF6 24940735 2980721 Negative_regulation TP63 LANCL1 24098413 2856189 Negative_regulation TP63 MYCN 24556696 572361 Negative_regulation TP63 MYLIP 20485546 2450390 Negative_regulation TP63 MYLIP 24039884 2845014 Negative_regulation TP63 PDCD1LG2 23149662 1919534 Negative_regulation TP63 PLK1 23948487 2184112 Negative_regulation TP63 PRDX2 22073300 2569845 Negative_regulation TP63 PTBP1 23675302 3061401 Negative_regulation TP63 PTBP2 23675302 3061398 Negative_regulation TP63 PTGES3 16022731 1844840 Negative_regulation TP63 RETN 20591185 353484 Negative_regulation TP63 TERT 16022731 1844839 Negative_regulation TP63 TLR1 18584038 3072560 Negative_regulation TP63 TLR1 18584038 3072760 Negative_regulation TP63 TLR1 18584038 3072761 Negative_regulation TP63 TLR10 18584038 3072568 Negative_regulation TP63 TLR10 18584038 3072776 Negative_regulation TP63 TLR10 18584038 3072777 Negative_regulation TP63 TLR2 18584038 3072561 Negative_regulation TP63 TLR2 18584038 3072762 Negative_regulation TP63 TLR2 18584038 3072763 Negative_regulation TP63 TLR3 18584038 3072562 Negative_regulation TP63 TLR3 18584038 3072764 Negative_regulation TP63 TLR3 18584038 3072765 Negative_regulation TP63 TLR4 18584038 3072563 Negative_regulation TP63 TLR4 18584038 3072766 Negative_regulation TP63 TLR4 18584038 3072767 Negative_regulation TP63 TLR5 18584038 3072564 Negative_regulation TP63 TLR5 18584038 3072768 Negative_regulation TP63 TLR5 18584038 3072769 Negative_regulation TP63 TLR6 18584038 3072569 Negative_regulation TP63 TLR6 18584038 3072778 Negative_regulation TP63 TLR6 18584038 3072779 Negative_regulation TP63 TLR7 18584038 3072565 Negative_regulation TP63 TLR7 18584038 3072770 Negative_regulation TP63 TLR7 18584038 3072771 Negative_regulation TP63 TLR8 18584038 3072566 Negative_regulation TP63 TLR8 18584038 3072772 Negative_regulation TP63 TLR8 18584038 3072773 Negative_regulation TP63 TLR9 18584038 3072567 Negative_regulation TP63 TLR9 18584038 3072774 Negative_regulation TP63 TLR9 18584038 3072775 Negative_regulation TP63 TP53 22580601 2146904 Negative_regulation TP63 TSLP 19273626 1554299 Negative_regulation TP63 UVRAG 24621512 2933502 Negative_regulation TP63 YAP1 24621512 2933503 Negative_regulation TPM1 TMOD1 12975349 1297046 Negative_regulation TPM1 TMOD1 2380244 1405712 Negative_regulation TPM1 TMOD1 2380244 1405819 Negative_regulation TPM1 TMOD1 7798317 1441714 Negative_regulation TPM2 TMOD1 12975349 1297047 Negative_regulation TPM2 TMOD1 2380244 1405716 Negative_regulation TPM2 TMOD1 2380244 1405823 Negative_regulation TPM2 TMOD1 7798317 1441718 Negative_regulation TPM3 TMOD1 12975349 1297048 Negative_regulation TPM3 TMOD1 2380244 1405720 Negative_regulation TPM3 TMOD1 2380244 1405827 Negative_regulation TPM3 TMOD1 7798317 1441722 Negative_regulation TPM4 TMOD1 12975349 1297049 Negative_regulation TPM4 TMOD1 2380244 1405724 Negative_regulation TPM4 TMOD1 2380244 1405831 Negative_regulation TPM4 TMOD1 7798317 1441726 Negative_regulation TRADD FOXO1 20604938 329355 Negative_regulation TRAF1 TNF 11696595 1521648 Negative_regulation TRAF1 TNF 16115325 1036146 Negative_regulation TRAF1 TNF 24457959 571478 Negative_regulation TRAF2 TNF 24457959 571480 Negative_regulation TRAF3 TNF 24457959 571482 Negative_regulation TRAF4 TNF 24457959 571484 Negative_regulation TRAF5 TNF 24457959 571486 Negative_regulation TRAF6 EPHB2 21048967 2480260 Negative_regulation TRAF6 EPHB2 22396737 2608332 Negative_regulation TRAF6 TNF 22396737 2608331 Negative_regulation TRAF6 TNF 24457959 571488 Negative_regulation TRAF7 TNF 24457959 571490 Negative_regulation TRIB3 FOXO1 24490110 3151520 Negative_regulation TRIM63 FBXO32 23755187 2801869 Negative_regulation TRIM63 FOXO1 24647719 1239284 Negative_regulation TRIM63 FOXO1 24971321 193316 Negative_regulation TRIM63 PGC 24478779 910961 Negative_regulation TRPC6 HRH1 24709960 618007 Negative_regulation TRPC6 HRH1 24709960 618009 Negative_regulation TSC1 EPHB2 19079609 2402386 Negative_regulation TSC1 EPHB2 21738705 2533370 Negative_regulation TSC1 EPHB2 22880048 2673706 Negative_regulation TSC1 EPHB2 22888331 903211 Negative_regulation TSC1 EPHB2 24743740 573703 Negative_regulation TSC2 EPHB2 21738705 2533374 Negative_regulation TSC2 EPHB2 21834980 1697674 Negative_regulation TSC2 EPHB2 22888331 903215 Negative_regulation TSLP FLG 25171086 3004184 Negative_regulation TSPAN3 CLDN10 23752226 1572325 Negative_regulation TTN FHL1 24367651 2900458 Negative_regulation TWIST1 TNF 16831897 1541142 Negative_regulation TXNDC9 FOXO1 22654904 680306 Negative_regulation TXNIP FOXO1 24112473 270049 Negative_regulation TXNIP IL1B 23915129 359285 Negative_regulation TXNIP TLR7 23520550 2769085 Negative_regulation TYR TNF 23445687 294247 Negative_regulation UBE2V1 EPHB2 21048967 2480261 Negative_regulation UBE2V1 EPHB2 22396737 2608334 Negative_regulation UBE2V1 TNF 22396737 2608333 Negative_regulation UCA1 TBX3 24876127 758388 Negative_regulation UCA1 TBX3 24876127 758406 Negative_regulation UCP1 PGC 22035495 520084 Negative_regulation UCP1 PGC 22649390 875124 Negative_regulation UCP1 PGC 25566082 967307 Negative_regulation UCP1 TNF 24236066 2878337 Negative_regulation UCP2 FAS 24086674 2855499 Negative_regulation UCP2 PGC 22742515 212911 Negative_regulation UGCG FOXO1 22888331 903178 Negative_regulation UGCG TNF 23717489 2797855 Negative_regulation UGT1A6 UGT1A8 25530784 827542 Negative_regulation UGT1A8 UGT1A6 25530784 827543 Negative_regulation UNC119 CEACAM6 21489288 1835861 Negative_regulation UNC13D STAT4 24842371 1576359 Negative_regulation UNC13D STAT4 24842371 1576360 Negative_regulation UNC50 CEACAM6 21489288 1835862 Negative_regulation UNC5B AGAP2 21460185 1789243 Negative_regulation UNC5B AGAP2 21460185 1789312 Negative_regulation UNC5B AGAP2 21460185 1789313 Negative_regulation UNC5B AGAP2 21460185 1789351 Negative_regulation UNC5B AGAP2 21460185 1789369 Negative_regulation UNC5B AGAP2 23770988 18014 Negative_regulation UNC5B APLP2 22989406 1896465 Negative_regulation UNC79 CEACAM6 21489288 1835863 Negative_regulation UNC80 CEACAM6 21489288 1835864 Negative_regulation UPF1 TNF 21569625 1723648 Negative_regulation UPF1 TNF 24086143 2350903 Negative_regulation UPF2 TNF 21569625 1723641 Negative_regulation UPF2 TNF 24086143 2350888 Negative_regulation UPF3B TNF 21569625 1723643 Negative_regulation UPF3B TNF 24086143 2350892 Negative_regulation UPK1B FOXA1 22590586 2642251 Negative_regulation UPK3A FOXA1 22590586 2642252 Negative_regulation UPK3B FOXA1 22590586 2642253 Negative_regulation USP39 PCSK9 9606213 1467819 Negative_regulation USP9X NES 23861879 2820409 Negative_regulation UTRN PGC 24447845 3163264 Negative_regulation UVRAG TP63 24621512 2933501 Negative_regulation VASH1 TNF 22267953 2244393 Negative_regulation VASP TNF 25051011 2991128 Negative_regulation VASP TNF 25051011 2991131 Negative_regulation VASP TNF 25051011 2991132 Negative_regulation VASP TNF 25051011 2991133 Negative_regulation VASP TNF 25051011 2991134 Negative_regulation VASP TNF 25051011 2991137 Negative_regulation VASP TNF 25051011 2991138 Negative_regulation VASP TNF 25051011 2991140 Negative_regulation VASP TNF 25051011 2991147 Negative_regulation VASP TNF 25051011 2991157 Negative_regulation VAV1 ITGB2 16203869 1538028 Negative_regulation VCAM1 ARSA 20877628 2475396 Negative_regulation VCAM1 ARSA 20877628 2475399 Negative_regulation VCAM1 HES2 24891765 1759489 Negative_regulation VCAM1 HES2 24891765 1759497 Negative_regulation VCAM1 ITGAL 10224287 1511713 Negative_regulation VCAM1 ITGAL 7525599 1436316 Negative_regulation VCAM1 TNF 16702604 1540320 Negative_regulation VCAM1 TNF 21808585 1682044 Negative_regulation VCAM1 TNF 21872249 139268 Negative_regulation VCAM1 TNF 22754320 1095961 Negative_regulation VCAM1 TNF 23136554 1060880 Negative_regulation VCAM1 TNF 24102059 184494 Negative_regulation VCAM1 TNF 24148690 1726359 Negative_regulation VCAM1 TNF 24468053 1920527 Negative_regulation VCAM1 TNF 24516119 1575037 Negative_regulation VCAM1 TNF 25541965 3035958 Negative_regulation VDR KLF9 24616223 1416948 Negative_regulation VDR TLR7 23589715 980636 Negative_regulation VDR TLR7 24661536 290298 Negative_regulation VDR TNF 22880111 2674463 Negative_regulation VDR TNF 22880111 2674467 Negative_regulation VDR TNF 25222475 3007421 Negative_regulation VEGFA ADAMTS1 20619343 1731732 Negative_regulation VEGFA ANGPT1 18274606 831112 Negative_regulation VEGFA ANGPT1 18835934 707040 Negative_regulation VEGFA ANGPT1 22558265 2624902 Negative_regulation VEGFA ANGPT1 22558265 2624903 Negative_regulation VEGFA ANGPT1 22558265 2624913 Negative_regulation VEGFA ANGPT1 23036162 660342 Negative_regulation VEGFA ANGPT1 23036162 660345 Negative_regulation VEGFA ANGPT1 23036162 660346 Negative_regulation VEGFA ANGPT1 24376824 2902374 Negative_regulation VEGFA ARSA 21826202 2540778 Negative_regulation VEGFA ARSA 21826202 2540780 Negative_regulation VEGFA ARSA 21826202 2540781 Negative_regulation VEGFA ARSA 21826202 2540785 Negative_regulation VEGFA CCND1 19358707 659148 Negative_regulation VEGFA CCND1 19851352 487442 Negative_regulation VEGFA CCND1 24069553 1706819 Negative_regulation VEGFA CCND1 24800233 190026 Negative_regulation VEGFA CHI3L1 23755018 961413 Negative_regulation VEGFA CTGF 21535871 404669 Negative_regulation VEGFA CTGF 24932681 2980387 Negative_regulation VEGFA EGLN3 20978507 436088 Negative_regulation VEGFA EGLN3 22905089 2675267 Negative_regulation VEGFA EPHB2 18852899 2397636 Negative_regulation VEGFA EPHB2 21544242 2517392 Negative_regulation VEGFA FOXO1 21860419 2142149 Negative_regulation VEGFA FOXO1 22384192 2607234 Negative_regulation VEGFA MAP2K6 19812696 2428007 Negative_regulation VEGFA MMP28 11076665 418141 Negative_regulation VEGFA MMP28 22848429 2668881 Negative_regulation VEGFA MMP7 11076665 418156 Negative_regulation VEGFA MMP7 22848429 2668896 Negative_regulation VEGFA PLAT 22432023 2611602 Negative_regulation VEGFA PTGER2 22012553 494210 Negative_regulation VEGFA S100A7 23618129 3226607 Negative_regulation VEGFA TFPI2 23497249 268033 Negative_regulation VEGFA TLR7 25309919 201102 Negative_regulation VEGFA TNF 22158049 2144817 Negative_regulation VEGFA TNFSF10 21209944 2492512 Negative_regulation VEGFA ZFP57 15860771 2016220 Negative_regulation VEGFC EPHB2 23344023 1100624 Negative_regulation VIM CLDN10 23752226 1572298 Negative_regulation VIM EPHB2 23173060 2719470 Negative_regulation VIM EPHB2 24466305 2914175 Negative_regulation VIM FAS 11121444 1265869 Negative_regulation VIM OLFM4 24495253 1482920 Negative_regulation VIM PLAU 22792020 686359 Negative_regulation VIM WIF1 20573255 1856506 Negative_regulation VLDLR EPHB2 11266465 1269090 Negative_regulation VLDLR PCSK9 20427281 1187564 Negative_regulation VLDLR PCSK9 24252756 179023 Negative_regulation VSNL1 EGF 22479362 2614931 Negative_regulation VSNL1 EGF 22479362 2614937 Negative_regulation VSNL1 EGF 22479362 2614948 Negative_regulation VSNL1 MYLIP 23823624 2808820 Negative_regulation VWF HES2 22270471 1146760 Negative_regulation WDR18 MAP2K6 25051360 2196608 Negative_regulation WDR5 HES2 23849347 660478 Negative_regulation WDR61 F2R PMC2756345 495995 Negative_regulation WDR61 LPCAT1 25415055 177540 Negative_regulation WDR61 TNF 18472926 1743191 Negative_regulation WDR61 TNF 3119758 1580176 Negative_regulation WIF1 MYLIP 24755295 1873935 Negative_regulation WIF1 MYLIP 24755295 1873940 Negative_regulation WIF1 WNT1 20573255 1856565 Negative_regulation WIF1 WNT1 20844743 2474595 Negative_regulation WIF1 WNT1 22325146 1864945 Negative_regulation WIF1 WNT11 20573255 1856566 Negative_regulation WIF1 WNT11 20844743 2474596 Negative_regulation WIF1 WNT11 22325146 1864946 Negative_regulation WIF1 WNT16 20573255 1856571 Negative_regulation WIF1 WNT16 20844743 2474601 Negative_regulation WIF1 WNT16 22325146 1864951 Negative_regulation WIF1 WNT2 20573255 1856567 Negative_regulation WIF1 WNT2 20844743 2474597 Negative_regulation WIF1 WNT2 22325146 1864947 Negative_regulation WIF1 WNT3 20573255 1856568 Negative_regulation WIF1 WNT3 20844743 2474598 Negative_regulation WIF1 WNT3 22325146 1864948 Negative_regulation WIF1 WNT4 20573255 1856569 Negative_regulation WIF1 WNT4 20844743 2474599 Negative_regulation WIF1 WNT4 22325146 1864949 Negative_regulation WIF1 WNT6 20573255 1856570 Negative_regulation WIF1 WNT6 20844743 2474600 Negative_regulation WIF1 WNT6 22325146 1864950 Negative_regulation WNK1 ARSA 20137092 1722979 Negative_regulation WNK1 ARSA 24039842 2844931 Negative_regulation WNK1 CCND1 25412312 579210 Negative_regulation WNK1 EPHB2 23573134 818424 Negative_regulation WNK1 EPHB2 23573134 818425 Negative_regulation WNK1 EPHB2 23734186 2799530 Negative_regulation WNK1 FAS 21364648 549823 Negative_regulation WNK1 ID1 19002171 431444 Negative_regulation WNK1 MMP28 22359588 2598003 Negative_regulation WNK1 MMP7 22359588 2598019 Negative_regulation WNK1 TNF 15175101 523490 Negative_regulation WNK1 TNF 15175101 523690 Negative_regulation WNK1 TNF 21306441 1889360 Negative_regulation WNK1 TNF 21573233 2523015 Negative_regulation WNK1 TNF 21573233 2523019 Negative_regulation WNK1 TNF 21915344 2553422 Negative_regulation WNK1 TNF 22076152 2570315 Negative_regulation WNK1 TNF 23409033 2753306 Negative_regulation WNK1 TNF 23593410 2781155 Negative_regulation WNK1 TNF 24066693 269790 Negative_regulation WNK1 TNF 24864134 1758825 Negative_regulation WNT1 AXIN2 18986540 2001148 Negative_regulation WNT1 AXIN2 19909509 400615 Negative_regulation WNT1 AXIN2 21317451 2175076 Negative_regulation WNT1 AXIN2 21706018 1966875 Negative_regulation WNT1 AXIN2 22325146 1864753 Negative_regulation WNT1 AXIN2 22957046 2685851 Negative_regulation WNT1 AXIN2 22957046 2685852 Negative_regulation WNT1 AXIN2 22957046 2685853 Negative_regulation WNT1 AXIN2 22957046 2685854 Negative_regulation WNT1 AXIN2 22957046 2686268 Negative_regulation WNT1 AXIN2 22957046 2686374 Negative_regulation WNT1 AXIN2 22957046 2686389 Negative_regulation WNT1 AXIN2 22957046 2686390 Negative_regulation WNT1 AXIN2 23144924 2714870 Negative_regulation WNT1 AXIN2 23982808 1142037 Negative_regulation WNT1 AXIN2 24474204 3081433 Negative_regulation WNT1 AXIN2 24594309 522569 Negative_regulation WNT1 CCND1 22570653 1673733 Negative_regulation WNT1 CTGF 22438586 1801421 Negative_regulation WNT1 EPHB2 22701736 2652358 Negative_regulation WNT1 FOXO1 20928874 1237810 Negative_regulation WNT1 FOXO1 20942928 362754 Negative_regulation WNT1 FOXO1 21483041 29452 Negative_regulation WNT1 LHX4 22180728 2277937 Negative_regulation WNT1 MAP2K6 22248814 2177304 Negative_regulation WNT1 MAP2K6 22701736 2652364 Negative_regulation WNT1 MAP2K6 23670595 1106883 Negative_regulation WNT1 MSX1 22383889 2331866 Negative_regulation WNT1 MSX1 23789101 169759 Negative_regulation WNT1 RGS2 23755177 2801743 Negative_regulation WNT1 TNF 24286133 130166 Negative_regulation WNT1 TSPAN1 20837773 1379369 Negative_regulation WNT1 WIF1 20573255 1856558 Negative_regulation WNT1 WIF1 20844743 2474588 Negative_regulation WNT1 WIF1 21083932 330500 Negative_regulation WNT1 WIF1 22073235 2569611 Negative_regulation WNT1 WIF1 22447857 722493 Negative_regulation WNT1 WIF1 23639831 1881556 Negative_regulation WNT1 WIF1 24618337 1872969 Negative_regulation WNT1 WIF1 24632949 548619 Negative_regulation WNT1 WIF1 24632949 548620 Negative_regulation WNT1 WIF1 24978435 504723 Negative_regulation WNT11 AXIN2 18986540 2001150 Negative_regulation WNT11 AXIN2 19909509 400617 Negative_regulation WNT11 AXIN2 21317451 2175078 Negative_regulation WNT11 AXIN2 21706018 1966876 Negative_regulation WNT11 AXIN2 22325146 1864755 Negative_regulation WNT11 AXIN2 22957046 2685866 Negative_regulation WNT11 AXIN2 22957046 2685867 Negative_regulation WNT11 AXIN2 22957046 2685868 Negative_regulation WNT11 AXIN2 22957046 2685869 Negative_regulation WNT11 AXIN2 22957046 2686270 Negative_regulation WNT11 AXIN2 22957046 2686376 Negative_regulation WNT11 AXIN2 22957046 2686393 Negative_regulation WNT11 AXIN2 22957046 2686394 Negative_regulation WNT11 AXIN2 23144924 2714872 Negative_regulation WNT11 AXIN2 24474204 3081435 Negative_regulation WNT11 AXIN2 24594309 522571 Negative_regulation WNT11 CCND1 22570653 1673735 Negative_regulation WNT11 CTGF 22438586 1801422 Negative_regulation WNT11 EPHB2 22701736 2652366 Negative_regulation WNT11 FOXO1 20928874 1237814 Negative_regulation WNT11 FOXO1 20942928 362758 Negative_regulation WNT11 FOXO1 21483041 29456 Negative_regulation WNT11 LHX4 22180728 2277945 Negative_regulation WNT11 MAP2K6 22248814 2177311 Negative_regulation WNT11 MAP2K6 22701736 2652372 Negative_regulation WNT11 MAP2K6 23670595 1106890 Negative_regulation WNT11 MSX1 22383889 2331868 Negative_regulation WNT11 RGS2 23755177 2801745 Negative_regulation WNT11 TNF 24286133 130167 Negative_regulation WNT11 TSPAN1 20837773 1379392 Negative_regulation WNT11 WIF1 20573255 1856559 Negative_regulation WNT11 WIF1 20844743 2474589 Negative_regulation WNT11 WIF1 21083932 330502 Negative_regulation WNT11 WIF1 22073235 2569612 Negative_regulation WNT11 WIF1 22447857 722495 Negative_regulation WNT11 WIF1 23639831 1881559 Negative_regulation WNT11 WIF1 24618337 1872970 Negative_regulation WNT11 WIF1 24632949 548621 Negative_regulation WNT11 WIF1 24632949 548622 Negative_regulation WNT11 WIF1 24978435 504724 Negative_regulation WNT16 AXIN2 18986540 2001160 Negative_regulation WNT16 AXIN2 19909509 400627 Negative_regulation WNT16 AXIN2 21317451 2175088 Negative_regulation WNT16 AXIN2 21706018 1966881 Negative_regulation WNT16 AXIN2 22325146 1864765 Negative_regulation WNT16 AXIN2 22957046 2685941 Negative_regulation WNT16 AXIN2 22957046 2685942 Negative_regulation WNT16 AXIN2 22957046 2685943 Negative_regulation WNT16 AXIN2 22957046 2685944 Negative_regulation WNT16 AXIN2 22957046 2686280 Negative_regulation WNT16 AXIN2 22957046 2686386 Negative_regulation WNT16 AXIN2 22957046 2686413 Negative_regulation WNT16 AXIN2 22957046 2686414 Negative_regulation WNT16 AXIN2 23144924 2714882 Negative_regulation WNT16 AXIN2 24474204 3081445 Negative_regulation WNT16 AXIN2 24594309 522581 Negative_regulation WNT16 CCND1 22570653 1673763 Negative_regulation WNT16 CTGF 22438586 1801427 Negative_regulation WNT16 EPHB2 22701736 2652406 Negative_regulation WNT16 FOXO1 20928874 1237834 Negative_regulation WNT16 FOXO1 20942928 362778 Negative_regulation WNT16 FOXO1 21483041 29476 Negative_regulation WNT16 LHX4 22180728 2277985 Negative_regulation WNT16 MAP2K6 22248814 2177353 Negative_regulation WNT16 MAP2K6 22701736 2652412 Negative_regulation WNT16 MAP2K6 23670595 1106925 Negative_regulation WNT16 MSX1 22383889 2331878 Negative_regulation WNT16 RGS2 23755177 2801755 Negative_regulation WNT16 TNF 24286133 130172 Negative_regulation WNT16 TSPAN1 20837773 1379507 Negative_regulation WNT16 WIF1 20573255 1856564 Negative_regulation WNT16 WIF1 20844743 2474594 Negative_regulation WNT16 WIF1 21083932 330512 Negative_regulation WNT16 WIF1 22073235 2569617 Negative_regulation WNT16 WIF1 22447857 722505 Negative_regulation WNT16 WIF1 23639831 1881574 Negative_regulation WNT16 WIF1 24618337 1872975 Negative_regulation WNT16 WIF1 24632949 548631 Negative_regulation WNT16 WIF1 24632949 548632 Negative_regulation WNT16 WIF1 24978435 504729 Negative_regulation WNT2 AXIN2 18986540 2001152 Negative_regulation WNT2 AXIN2 19909509 400619 Negative_regulation WNT2 AXIN2 21317451 2175080 Negative_regulation WNT2 AXIN2 21706018 1966877 Negative_regulation WNT2 AXIN2 22325146 1864757 Negative_regulation WNT2 AXIN2 22957046 2685881 Negative_regulation WNT2 AXIN2 22957046 2685882 Negative_regulation WNT2 AXIN2 22957046 2685883 Negative_regulation WNT2 AXIN2 22957046 2685884 Negative_regulation WNT2 AXIN2 22957046 2686272 Negative_regulation WNT2 AXIN2 22957046 2686378 Negative_regulation WNT2 AXIN2 22957046 2686397 Negative_regulation WNT2 AXIN2 22957046 2686398 Negative_regulation WNT2 AXIN2 23144924 2714874 Negative_regulation WNT2 AXIN2 23341776 2341352 Negative_regulation WNT2 AXIN2 24474204 3081437 Negative_regulation WNT2 AXIN2 24594309 522573 Negative_regulation WNT2 CCND1 22570653 1673737 Negative_regulation WNT2 CTGF 22438586 1801423 Negative_regulation WNT2 EPHB2 22701736 2652374 Negative_regulation WNT2 FOXO1 20928874 1237818 Negative_regulation WNT2 FOXO1 20942928 362762 Negative_regulation WNT2 FOXO1 21483041 29460 Negative_regulation WNT2 LHX4 22180728 2277953 Negative_regulation WNT2 MAP2K6 22248814 2177318 Negative_regulation WNT2 MAP2K6 22701736 2652380 Negative_regulation WNT2 MAP2K6 23670595 1106897 Negative_regulation WNT2 MSX1 22383889 2331870 Negative_regulation WNT2 MSX1 23383281 2750047 Negative_regulation WNT2 RGS2 23755177 2801747 Negative_regulation WNT2 TNF 24286133 130168 Negative_regulation WNT2 TSPAN1 20837773 1379415 Negative_regulation WNT2 WIF1 20573255 1856560 Negative_regulation WNT2 WIF1 20844743 2474590 Negative_regulation WNT2 WIF1 21083932 330504 Negative_regulation WNT2 WIF1 22073235 2569613 Negative_regulation WNT2 WIF1 22447857 722497 Negative_regulation WNT2 WIF1 23639831 1881562 Negative_regulation WNT2 WIF1 24618337 1872971 Negative_regulation WNT2 WIF1 24632949 548623 Negative_regulation WNT2 WIF1 24632949 548624 Negative_regulation WNT2 WIF1 24978435 504725 Negative_regulation WNT3 AXIN2 18986540 2001154 Negative_regulation WNT3 AXIN2 19909509 400621 Negative_regulation WNT3 AXIN2 21317451 2175082 Negative_regulation WNT3 AXIN2 21706018 1966878 Negative_regulation WNT3 AXIN2 22325146 1864759 Negative_regulation WNT3 AXIN2 22957046 2685896 Negative_regulation WNT3 AXIN2 22957046 2685897 Negative_regulation WNT3 AXIN2 22957046 2685898 Negative_regulation WNT3 AXIN2 22957046 2685899 Negative_regulation WNT3 AXIN2 22957046 2686274 Negative_regulation WNT3 AXIN2 22957046 2686380 Negative_regulation WNT3 AXIN2 22957046 2686401 Negative_regulation WNT3 AXIN2 22957046 2686402 Negative_regulation WNT3 AXIN2 23144924 2714876 Negative_regulation WNT3 AXIN2 24474204 3081439 Negative_regulation WNT3 AXIN2 24594309 522575 Negative_regulation WNT3 CCND1 22570653 1673739 Negative_regulation WNT3 CTGF 22438586 1801424 Negative_regulation WNT3 EPHB2 22701736 2652382 Negative_regulation WNT3 FOXO1 20928874 1237822 Negative_regulation WNT3 FOXO1 20942928 362766 Negative_regulation WNT3 FOXO1 21483041 29464 Negative_regulation WNT3 LHX4 22180728 2277961 Negative_regulation WNT3 MAP2K6 22248814 2177325 Negative_regulation WNT3 MAP2K6 22701736 2652388 Negative_regulation WNT3 MAP2K6 23670595 1106904 Negative_regulation WNT3 MSX1 22383889 2331872 Negative_regulation WNT3 RGS2 23755177 2801749 Negative_regulation WNT3 TNF 24286133 130169 Negative_regulation WNT3 TSPAN1 20837773 1379438 Negative_regulation WNT3 WIF1 20573255 1856561 Negative_regulation WNT3 WIF1 20844743 2474591 Negative_regulation WNT3 WIF1 21083932 330506 Negative_regulation WNT3 WIF1 22073235 2569614 Negative_regulation WNT3 WIF1 22447857 722499 Negative_regulation WNT3 WIF1 23639831 1881565 Negative_regulation WNT3 WIF1 24618337 1872972 Negative_regulation WNT3 WIF1 24632949 548625 Negative_regulation WNT3 WIF1 24632949 548626 Negative_regulation WNT3 WIF1 24978435 504726 Negative_regulation WNT3A AXIN2 24594309 522625 Negative_regulation WNT3A CCND1 24273411 2122485 Negative_regulation WNT3A TNF 23922826 2826777 Negative_regulation WNT3A TNF 24971753 2985052 Negative_regulation WNT4 AXIN2 18986540 2001156 Negative_regulation WNT4 AXIN2 19909509 400623 Negative_regulation WNT4 AXIN2 21317451 2175084 Negative_regulation WNT4 AXIN2 21706018 1966879 Negative_regulation WNT4 AXIN2 22325146 1864761 Negative_regulation WNT4 AXIN2 22957046 2685911 Negative_regulation WNT4 AXIN2 22957046 2685912 Negative_regulation WNT4 AXIN2 22957046 2685913 Negative_regulation WNT4 AXIN2 22957046 2685914 Negative_regulation WNT4 AXIN2 22957046 2686276 Negative_regulation WNT4 AXIN2 22957046 2686382 Negative_regulation WNT4 AXIN2 22957046 2686405 Negative_regulation WNT4 AXIN2 22957046 2686406 Negative_regulation WNT4 AXIN2 23144924 2714878 Negative_regulation WNT4 AXIN2 24474204 3081441 Negative_regulation WNT4 AXIN2 24594309 522577 Negative_regulation WNT4 CCND1 22570653 1673741 Negative_regulation WNT4 CTGF 22438586 1801425 Negative_regulation WNT4 EPHB2 22701736 2652390 Negative_regulation WNT4 FOXO1 20928874 1237826 Negative_regulation WNT4 FOXO1 20942928 362770 Negative_regulation WNT4 FOXO1 21483041 29468 Negative_regulation WNT4 LHX4 22180728 2277969 Negative_regulation WNT4 MAP2K6 22248814 2177332 Negative_regulation WNT4 MAP2K6 22701736 2652396 Negative_regulation WNT4 MAP2K6 23670595 1106911 Negative_regulation WNT4 MSX1 22383889 2331874 Negative_regulation WNT4 RGS2 23755177 2801751 Negative_regulation WNT4 TNF 24286133 130170 Negative_regulation WNT4 TSPAN1 20837773 1379461 Negative_regulation WNT4 WIF1 20573255 1856562 Negative_regulation WNT4 WIF1 20844743 2474592 Negative_regulation WNT4 WIF1 21083932 330508 Negative_regulation WNT4 WIF1 22073235 2569615 Negative_regulation WNT4 WIF1 22447857 722501 Negative_regulation WNT4 WIF1 23639831 1881568 Negative_regulation WNT4 WIF1 24618337 1872973 Negative_regulation WNT4 WIF1 24632949 548627 Negative_regulation WNT4 WIF1 24632949 548628 Negative_regulation WNT4 WIF1 24978435 504727 Negative_regulation WNT5B MAP2K6 21418646 305006 Negative_regulation WNT6 AXIN2 18986540 2001158 Negative_regulation WNT6 AXIN2 19909509 400625 Negative_regulation WNT6 AXIN2 21317451 2175086 Negative_regulation WNT6 AXIN2 21706018 1966880 Negative_regulation WNT6 AXIN2 22325146 1864763 Negative_regulation WNT6 AXIN2 22957046 2685926 Negative_regulation WNT6 AXIN2 22957046 2685927 Negative_regulation WNT6 AXIN2 22957046 2685928 Negative_regulation WNT6 AXIN2 22957046 2685929 Negative_regulation WNT6 AXIN2 22957046 2686278 Negative_regulation WNT6 AXIN2 22957046 2686384 Negative_regulation WNT6 AXIN2 22957046 2686409 Negative_regulation WNT6 AXIN2 22957046 2686410 Negative_regulation WNT6 AXIN2 23144924 2714880 Negative_regulation WNT6 AXIN2 24474204 3081443 Negative_regulation WNT6 AXIN2 24594309 522579 Negative_regulation WNT6 CCND1 22570653 1673743 Negative_regulation WNT6 CTGF 22438586 1801426 Negative_regulation WNT6 EPHB2 22701736 2652398 Negative_regulation WNT6 FOXO1 20928874 1237830 Negative_regulation WNT6 FOXO1 20942928 362774 Negative_regulation WNT6 FOXO1 21483041 29472 Negative_regulation WNT6 LHX4 22180728 2277977 Negative_regulation WNT6 MAP2K6 22248814 2177339 Negative_regulation WNT6 MAP2K6 22701736 2652404 Negative_regulation WNT6 MAP2K6 23670595 1106918 Negative_regulation WNT6 MSX1 22383889 2331876 Negative_regulation WNT6 RGS2 23755177 2801753 Negative_regulation WNT6 TNF 24286133 130171 Negative_regulation WNT6 TSPAN1 20837773 1379484 Negative_regulation WNT6 WIF1 20573255 1856563 Negative_regulation WNT6 WIF1 20844743 2474593 Negative_regulation WNT6 WIF1 21083932 330510 Negative_regulation WNT6 WIF1 22073235 2569616 Negative_regulation WNT6 WIF1 22447857 722503 Negative_regulation WNT6 WIF1 23639831 1881571 Negative_regulation WNT6 WIF1 24618337 1872974 Negative_regulation WNT6 WIF1 24632949 548629 Negative_regulation WNT6 WIF1 24632949 548630 Negative_regulation WNT6 WIF1 24978435 504728 Negative_regulation WNT7A DES 16759992 792664 Negative_regulation WNT7A DKK1 25170755 3003861 Negative_regulation WNT7A DNMT3A 22403725 2609245 Negative_regulation WNT7A SFRP4 25170755 3003810 Negative_regulation WNT7A SFRP4 25170755 3003858 Negative_regulation WNT7B MSX1 23383281 2750050 Negative_regulation WNT8A MAP2K6 21418646 304999 Negative_regulation WTS F2R 23940457 2283800 Negative_regulation WWOX TNF 11960552 276583 Negative_regulation XIAP FOXO1 23653632 883828 Negative_regulation XIAP TNFSF10 20442774 2448910 Negative_regulation XIAP TNFSF10 20461078 434813 Negative_regulation XIAP TNFSF10 25257790 1731038 Negative_regulation XPO1 NES 11425870 1271808 Negative_regulation XRCC5 CAPN8 23056924 139863 Negative_regulation XRCC6 CAPN8 23056924 140357 Negative_regulation XRN1 TNF 21569625 1723645 Negative_regulation XRN1 TNF 24086143 2350896 Negative_regulation XRN2 TNF 21569625 1723639 Negative_regulation XRN2 TNF 24086143 2350884 Negative_regulation YAP1 EPHB2 23857250 2156929 Negative_regulation YAP1 MAP2K6 23857250 2156935 Negative_regulation YAP1 NES 21156173 850871 Negative_regulation YAP1 TP63 24621512 2933504 Negative_regulation YBX1 EPHB2 23967153 2834714 Negative_regulation YWHAB MAP2K6 17958888 1242758 Negative_regulation YWHAB MAP2K6 23226069 2249750 Negative_regulation YWHAH RASD1 21915321 2553260 Negative_regulation ZAP70 FAS 19487421 1555088 Negative_regulation ZBTB46 TLR7 24979752 2985701 Negative_regulation ZC3H12A EPHB2 20137095 375188 Negative_regulation ZC3H12A RNASE1 21115689 1562113 Negative_regulation ZC3H12A RNASE7 21115689 1562121 Negative_regulation ZEB1 EPHB2 24466305 2914174 Negative_regulation ZEB1 HBEGF 22592159 1630914 Negative_regulation ZEB2 TGM2 22655269 940654 Negative_regulation ZFP36 EPHB2 24069363 2853118 Negative_regulation ZFP36 EPHB2 24324544 2890720 Negative_regulation ZFP57 BMP1 21539723 3168462 Negative_regulation ZFP57 BMP10 21539723 3168470 Negative_regulation ZFP57 BMP15 21539723 3168463 Negative_regulation ZFP57 BMP2 21539723 3168464 Negative_regulation ZFP57 BMP3 21539723 3168465 Negative_regulation ZFP57 BMP4 21539723 3168466 Negative_regulation ZFP57 BMP5 21539723 3168467 Negative_regulation ZFP57 BMP6 21539723 3168468 Negative_regulation ZFP57 BMP7 21539723 3168469 Negative_regulation ZFP57 DKC1 25032857 577128 Negative_regulation ZFP57 DKC1 25032857 577129 Negative_regulation ZFP57 EBF1 23209378 2281026 Negative_regulation ZFP57 EBF1 23209378 2281062 Negative_regulation ZFP57 EBF1 23209380 2281098 Negative_regulation ZFP57 EBF1 23569325 1571136 Negative_regulation ZFP57 HDAC3 21173110 1383385 Negative_regulation ZFP57 HSP90AA1 25032857 577130 Negative_regulation ZFP57 HSP90AA1 25032857 577131 Negative_regulation ZFP57 MAPK3 24722354 2951187 Negative_regulation ZFP57 NFKB1 24294107 679671 Negative_regulation ZFP57 PTGES3 25032857 577126 Negative_regulation ZFP57 PTGES3 25032857 577127 Negative_regulation ZFP57 RELA 24294107 679672 Negative_regulation ZFP57 TERT 25032857 577124 Negative_regulation ZFP57 TERT 25032857 577125 Negative_regulation ZFP57 ZNF423 23762491 2804069 Negative_regulation ZNF148 ID1 25028095 1875794 Negative_regulation ZNF148 ID1 25028095 1875802 Negative_regulation ZNF148 ID1 25028095 1875813 Negative_regulation ZNF423 ZFP57 23762491 2804057 Negative_regulation ZNF703 IFI27 21328542 775874 Negative_regulation ZNF746 PGC 25099937 2995778 Negative_regulation ZYX EPHB2 22456508 1801500 Positive_regulation A4GALT TNF 16100442 1634625 Positive_regulation ABCA1 ARSA 20137092 1722989 Positive_regulation ABCA1 CAPN8 23634230 2785641 Positive_regulation ABCA1 CYP24A1 19787078 981265 Positive_regulation ABCA1 MAP2K6 23634230 2785518 Positive_regulation ABCA12 ABCG1 PMC4308859 135076 Positive_regulation ABCA12 CDC42 23829168 269316 Positive_regulation ABCA12 PAK1 23829168 269317 Positive_regulation ABCA12 TLR3 23353987 1632002 Positive_regulation ABCA12 TRG 19920924 742358 Positive_regulation ABCA12 YBX1 21423216 2138798 Positive_regulation ABCA4 ABCG1 PMC4308859 135082 Positive_regulation ABCA4 ACKR3 18268039 1549390 Positive_regulation ABCA4 CDC42 23829168 269340 Positive_regulation ABCA4 CLCN1 21423376 955164 Positive_regulation ABCA4 CXCR4 18268039 1549391 Positive_regulation ABCA4 EIF2AK2 23638202 2371863 Positive_regulation ABCA4 JAK1 23847761 945758 Positive_regulation ABCA4 KCNN4 25296378 1736729 Positive_regulation ABCA4 MTOR 23847761 945757 Positive_regulation ABCA4 PAK1 23829168 269341 Positive_regulation ABCA7 EPHB2 16908670 1331935 Positive_regulation ABCA7 EPHB2 16908670 1331936 Positive_regulation ABCA7 EPHB2 16908670 1331937 Positive_regulation ABCA7 EPHB2 16908670 1331949 Positive_regulation ABCB1 ABCG2 24040307 2846419 Positive_regulation ABCB1 ABCG2 24103790 626454 Positive_regulation ABCB1 ABCG2 24109177 742733 Positive_regulation ABCB1 EPHB2 23799854 440998 Positive_regulation ABCB1 FAS 11516336 994099 Positive_regulation ABCB1 FOXO1 20592766 2222452 Positive_regulation ABCB1 FOXO1 25566078 955128 Positive_regulation ABCB1 MX2 10070877 414018 Positive_regulation ABCB1 MX2 10070877 414023 Positive_regulation ABCB1 MX2 10070877 414024 Positive_regulation ABCB1 PLAU 19603017 432437 Positive_regulation ABCB1 PLAU 19603017 432442 Positive_regulation ABCB1 TNF 23642074 1666672 Positive_regulation ABCB11 ALOX5 25444678 590473 Positive_regulation ABCC1 ABCG2 24109177 742734 Positive_regulation ABCC1 EPHB2 22787275 1805507 Positive_regulation ABCC1 EPHB2 22787275 1805508 Positive_regulation ABCC1 MAP2K6 23320839 482785 Positive_regulation ABCC1 PLAU 19603017 432444 Positive_regulation ABCC6 TNF 21350659 217495 Positive_regulation ABCD1 TLR7 20827314 979334 Positive_regulation ABCD1 TNF 22530132 1079161 Positive_regulation ABCG1 ABCA12 PMC4308859 135088 Positive_regulation ABCG1 ABCA4 PMC4308859 135094 Positive_regulation ABCG1 MAP2K6 23634230 2785527 Positive_regulation ABCG2 ABCA3 21526180 2513884 Positive_regulation ABCG2 ABCB1 23028879 2693495 Positive_regulation ABCG2 ABCB1 24040307 2846423 Positive_regulation ABCG2 ABCC1 22545122 2623441 Positive_regulation ABCG2 ABL1 23259070 1719136 Positive_regulation ABCG2 AHR 25246735 1636197 Positive_regulation ABCG2 AHR 25246735 1636198 Positive_regulation ABCG2 AHR 25246735 1636200 Positive_regulation ABCG2 AKT1 21943250 734160 Positive_regulation ABCG2 AKT1 24391798 2904571 Positive_regulation ABCG2 AKT2 21943250 734161 Positive_regulation ABCG2 AKT2 24391798 2904572 Positive_regulation ABCG2 AKT3 21943250 734162 Positive_regulation ABCG2 AKT3 24391798 2904573 Positive_regulation ABCG2 BCR 23259070 1719135 Positive_regulation ABCG2 BCRP1 24523596 2249867 Positive_regulation ABCG2 BCRP2 24523596 2249863 Positive_regulation ABCG2 BCRP3 24523596 2249864 Positive_regulation ABCG2 BCRP4 24523596 2249865 Positive_regulation ABCG2 BCRP5 24523596 2249866 Positive_regulation ABCG2 BCRP6 24523596 2249868 Positive_regulation ABCG2 BCRP7 24523596 2249869 Positive_regulation ABCG2 BCRP8 24523596 2249870 Positive_regulation ABCG2 BCRP9 24523596 2249871 Positive_regulation ABCG2 BMI1 20625515 2455184 Positive_regulation ABCG2 BSG 25268615 1131336 Positive_regulation ABCG2 BTRC 22252524 3204983 Positive_regulation ABCG2 CAV1 22952907 2685004 Positive_regulation ABCG2 CD44 23368632 289277 Positive_regulation ABCG2 CD44 24124770 270075 Positive_regulation ABCG2 CDKN1A 24040307 2846422 Positive_regulation ABCG2 CSF3 22252524 3204984 Positive_regulation ABCG2 CUL1 22252524 3204985 Positive_regulation ABCG2 EGF 23009336 1867015 Positive_regulation ABCG2 EGFR 21731744 2532343 Positive_regulation ABCG2 EGFR 23009336 1867017 Positive_regulation ABCG2 ENO3 24454499 825096 Positive_regulation ABCG2 FOXM1 25213081 475628 Positive_regulation ABCG2 GABPA 24040073 2845430 Positive_regulation ABCG2 GIPC1 25469510 3031355 Positive_regulation ABCG2 GIPC2 25469510 3031356 Positive_regulation ABCG2 GIPC3 25469510 3031357 Positive_regulation ABCG2 GLI1 21625222 2139900 Positive_regulation ABCG2 GLI1 23557251 268248 Positive_regulation ABCG2 ISL1 25026296 2196409 Positive_regulation ABCG2 ISL2 25026296 2196408 Positive_regulation ABCG2 MAPK1 23226356 2724312 Positive_regulation ABCG2 MAPK10 23226356 2724313 Positive_regulation ABCG2 MAPK11 23226356 2724314 Positive_regulation ABCG2 MAPK12 23226356 2724315 Positive_regulation ABCG2 MAPK13 23226356 2724316 Positive_regulation ABCG2 MAPK14 23226356 2724317 Positive_regulation ABCG2 MAPK15 23226356 2724311 Positive_regulation ABCG2 MAPK3 23226356 2724318 Positive_regulation ABCG2 MAPK4 23226356 2724319 Positive_regulation ABCG2 MAPK6 23226356 2724320 Positive_regulation ABCG2 MAPK7 23226356 2724321 Positive_regulation ABCG2 MAPK8 23226356 2724322 Positive_regulation ABCG2 MAPK9 23226356 2724323 Positive_regulation ABCG2 MTOR 21512587 3128132 Positive_regulation ABCG2 MYLIP 20628378 435658 Positive_regulation ABCG2 MYLIP 22453125 438418 Positive_regulation ABCG2 MYLIP 24358977 1232715 Positive_regulation ABCG2 MYLIP 24454381 22631 Positive_regulation ABCG2 NANOG 21499299 2139024 Positive_regulation ABCG2 NANOG 21499299 2139037 Positive_regulation ABCG2 NFE2L2 24040073 2845434 Positive_regulation ABCG2 NKRF 24219920 833927 Positive_regulation ABCG2 OXA1L 20628378 435659 Positive_regulation ABCG2 PIK3CA 21943250 734163 Positive_regulation ABCG2 PIK3R1 21943250 734164 Positive_regulation ABCG2 PIM1 24040307 2846424 Positive_regulation ABCG2 PPARA 18288266 3071796 Positive_regulation ABCG2 PTEN 21943250 734165 Positive_regulation ABCG2 RUNX3 24040307 2846421 Positive_regulation ABCG2 SALL4 21526180 2513882 Positive_regulation ABCG2 SALL4 21526180 2513883 Positive_regulation ABCG2 SALL4 21526180 2513900 Positive_regulation ABCG2 SALL4 21526180 2513915 Positive_regulation ABCG2 SHBG 23028879 2693494 Positive_regulation ABCG2 SKP1 22252524 3204982 Positive_regulation ABCG2 SOX2 23009336 1867026 Positive_regulation ABCG2 SPP1 23935934 2828591 Positive_regulation ABI1 LIPG 21831845 1500637 Positive_regulation ABI1 TNF 22808230 2665190 Positive_regulation ABI1 TNF 22808230 2665199 Positive_regulation ABL1 ALOX5 19503090 1948722 Positive_regulation ABL1 EPHB2 14624253 2255215 Positive_regulation ABL1 PECAM1 23233201 1141369 Positive_regulation ABL1 TNF 22462553 1230500 Positive_regulation ACACA EPHB2 18651976 1897060 Positive_regulation ACACA FAS 24367387 824835 Positive_regulation ACACA LBP 25013763 194511 Positive_regulation ACACA SYNM 24381810 452473 Positive_regulation ACAD8 EPHB2 21559295 2518099 Positive_regulation ACAD8 EPHB2 21559295 2518116 Positive_regulation ACAD8 EPHB2 24045785 3137127 Positive_regulation ACAD8 EPHB2 24045785 3137192 Positive_regulation ACADM PGC 21904680 154551 Positive_regulation ACADM PGC 23012586 3229318 Positive_regulation ACADVL PGC 23093952 3076069 Positive_regulation ACAN ADAMTS1 17922907 109159 Positive_regulation ACAN ADAMTS1 22493487 1201709 Positive_regulation ACAN CTGF 19144181 112515 Positive_regulation ACAN CTGF 19152120 1478390 Positive_regulation ACAN CTGF 23951098 2833420 Positive_regulation ACAN MMP28 12718749 99781 Positive_regulation ACAN MMP28 18513402 110842 Positive_regulation ACAN MMP28 18513402 110872 Positive_regulation ACAN MMP28 22394620 124934 Positive_regulation ACAN MMP7 12718749 99796 Positive_regulation ACAN MMP7 18513402 110857 Positive_regulation ACAN MMP7 18513402 110887 Positive_regulation ACAN MMP7 22394620 124949 Positive_regulation ACAN TNF 15642133 102078 Positive_regulation ACAN TNF 15642133 102082 Positive_regulation ACAN TNF 15642133 102168 Positive_regulation ACD PECAM1 10725328 1256532 Positive_regulation ACD TNF 23342266 491909 Positive_regulation ACE EDN2 21085492 2482730 Positive_regulation ACE TNF 22649335 514886 Positive_regulation ACE UCA1 24876127 758398 Positive_regulation ACE2 FOXO1 21689484 404978 Positive_regulation ACKR3 EPHB2 21655198 2527624 Positive_regulation ACKR3 TNF 25084358 2994448 Positive_regulation ACKR3 TNF 25084358 2994452 Positive_regulation ACKR3 TNF 25084358 2994456 Positive_regulation ACKR3 TNF 25084358 2994459 Positive_regulation ACKR3 TNF 25084358 2994460 Positive_regulation ACKR3 TNF 25084358 2994462 Positive_regulation ACKR3 TNF 25084358 2994463 Positive_regulation ACP1 SRGN 4825245 1584412 Positive_regulation ACP2 ADAMTS1 22363291 956424 Positive_regulation ACP2 SRGN 4825245 1584413 Positive_regulation ACP5 SRGN 4825245 1584414 Positive_regulation ACP6 SRGN 4825245 1584415 Positive_regulation ACPP MMP28 20460372 1187869 Positive_regulation ACPP MMP7 20460372 1187884 Positive_regulation ACR RIC3 23950710 3063481 Positive_regulation ACR RIC3 23950710 3063483 Positive_regulation ACSM3 MIP 20731855 659652 Positive_regulation ACSM3 NNMT 23455543 1931965 Positive_regulation ACSM3 TNF 20731855 659650 Positive_regulation ACSM3 TNF 23904869 1641455 Positive_regulation ACSS1 FAS 24284429 1730417 Positive_regulation ACSS1 INS 22275878 2328859 Positive_regulation ACSS1 INS 22275878 2328869 Positive_regulation ACSS1 INS 22275878 2328872 Positive_regulation ACSS1 INS 22275878 2328881 Positive_regulation ACSS1 INS 22275878 2328893 Positive_regulation ACSS1 KLF15 20141633 315429 Positive_regulation ACSS1 KLF15 24600395 964294 Positive_regulation ACSS1 SIRT3 23868064 564092 Positive_regulation ACSS1 SIRT3 23888142 858654 Positive_regulation ACSS1 SLC27A1 22275878 2328887 Positive_regulation ACSS2 FAS 24284429 1730416 Positive_regulation ACSS3 FAS 24284429 1730418 Positive_regulation ACTB TNF 22761878 2659072 Positive_regulation ACTN4 F2R 21941675 1082232 Positive_regulation ACTR1A IFI27 22918948 1806770 Positive_regulation ACTR1A IFI27 22918948 1806855 Positive_regulation ACTR1A IFI27 22918948 1806856 Positive_regulation ACTR1A IFI27 22918948 1806880 Positive_regulation ACTR1A NES 15251038 277766 Positive_regulation ACTR2 EPHB2 22876286 2672630 Positive_regulation ACTR3 EPHB2 22876286 2672631 Positive_regulation AD5 TLR7 19008951 3042208 Positive_regulation ADAM10 EPHB2 22568950 518216 Positive_regulation ADAM10 HBEGF 21179550 2489109 Positive_regulation ADAM10 MMP28 24244825 205224 Positive_regulation ADAM10 MMP7 24244825 205239 Positive_regulation ADAM10 S100A7 19159013 2404518 Positive_regulation ADAM10 S100A7 19159013 2404519 Positive_regulation ADAM10 S100A7 19159013 2404521 Positive_regulation ADAM10 S100A7 19159013 2404522 Positive_regulation ADAM10 TNF 24520307 2167695 Positive_regulation ADAM10 TNF 24520307 2167696 Positive_regulation ADAM10 TNF 24520307 2167697 Positive_regulation ADAM10 TNF 24520307 2167698 Positive_regulation ADAM10 TNF 24520307 2167699 Positive_regulation ADAM10 TNF 24520307 2167700 Positive_regulation ADAM10 TNF 24520307 2167701 Positive_regulation ADAM10 TNF 24520307 2167702 Positive_regulation ADAM10 TNF 24520307 2167703 Positive_regulation ADAM11 HBEGF 21179550 2489111 Positive_regulation ADAM11 ITGAL 23590845 3121654 Positive_regulation ADAM11 MMP28 24244825 205246 Positive_regulation ADAM11 MMP7 24244825 205261 Positive_regulation ADAM11 TLR7 19703986 1556002 Positive_regulation ADAM11 TLR7 21326629 1239504 Positive_regulation ADAM11 TLR7 21559444 2519547 Positive_regulation ADAM11 TLR7 22953039 2233627 Positive_regulation ADAM11 TLR7 24098110 3064242 Positive_regulation ADAM11 TLR7 25222785 1045993 Positive_regulation ADAM11 TNF 11257135 1519087 Positive_regulation ADAM12 CTGF 22808268 2665299 Positive_regulation ADAM12 CTGF 22808268 2665301 Positive_regulation ADAM12 HBEGF 21179550 2489113 Positive_regulation ADAM12 MMP28 24244825 205268 Positive_regulation ADAM12 MMP7 24244825 205283 Positive_regulation ADAM15 HBEGF 21179550 2489115 Positive_regulation ADAM15 MMP28 24244825 205290 Positive_regulation ADAM15 MMP7 24244825 205305 Positive_regulation ADAM15 TNF 16277668 104591 Positive_regulation ADAM17 EPHB2 21386996 2506123 Positive_regulation ADAM17 EPHB2 23942551 728392 Positive_regulation ADAM17 HBEGF 21179550 2489117 Positive_regulation ADAM17 HBEGF 21386996 2506133 Positive_regulation ADAM17 IL1B 22792188 2661433 Positive_regulation ADAM17 MMP28 24244825 205312 Positive_regulation ADAM17 MMP28 25414771 206568 Positive_regulation ADAM17 MMP28 25414771 206658 Positive_regulation ADAM17 MMP7 24244825 205327 Positive_regulation ADAM17 MMP7 25414771 206583 Positive_regulation ADAM17 MMP7 25414771 206673 Positive_regulation ADAM17 TNF 23389627 1811760 Positive_regulation ADAM17 TNF 23389627 1811761 Positive_regulation ADAM17 TNF 23389627 1811762 Positive_regulation ADAM17 TNF 23389627 1811845 Positive_regulation ADAM17 TNF 23437303 2756407 Positive_regulation ADAM18 HBEGF 21179550 2489119 Positive_regulation ADAM18 MMP28 24244825 205334 Positive_regulation ADAM18 MMP7 24244825 205349 Positive_regulation ADAM19 HBEGF 21179550 2489121 Positive_regulation ADAM19 MMP28 24244825 205356 Positive_regulation ADAM19 MMP7 24244825 205371 Positive_regulation ADAM2 HBEGF 21179550 2489123 Positive_regulation ADAM2 MMP28 24244825 205378 Positive_regulation ADAM2 MMP7 24244825 205393 Positive_regulation ADAM20 HBEGF 21179550 2489125 Positive_regulation ADAM20 MMP28 24244825 205400 Positive_regulation ADAM20 MMP7 24244825 205415 Positive_regulation ADAM21 HBEGF 21179550 2489127 Positive_regulation ADAM21 MMP28 24244825 205422 Positive_regulation ADAM21 MMP7 24244825 205437 Positive_regulation ADAM22 HBEGF 21179550 2489129 Positive_regulation ADAM22 MMP28 24244825 205444 Positive_regulation ADAM22 MMP7 24244825 205459 Positive_regulation ADAM23 HBEGF 21179550 2489131 Positive_regulation ADAM23 MMP28 24244825 205466 Positive_regulation ADAM23 MMP7 24244825 205481 Positive_regulation ADAM28 HBEGF 21179550 2489133 Positive_regulation ADAM28 MMP28 24244825 205488 Positive_regulation ADAM28 MMP7 24244825 205503 Positive_regulation ADAM29 HBEGF 21179550 2489135 Positive_regulation ADAM29 MMP28 24244825 205510 Positive_regulation ADAM29 MMP7 24244825 205525 Positive_regulation ADAM30 HBEGF 21179550 2489137 Positive_regulation ADAM30 MMP28 24244825 205532 Positive_regulation ADAM30 MMP7 24244825 205547 Positive_regulation ADAM32 HBEGF 21179550 2489063 Positive_regulation ADAM32 MMP28 24244825 205202 Positive_regulation ADAM32 MMP7 24244825 205217 Positive_regulation ADAM33 HBEGF 21179550 2489061 Positive_regulation ADAM33 MMP28 24244825 205180 Positive_regulation ADAM33 MMP7 24244825 205195 Positive_regulation ADAM5 HBEGF 21179550 2489139 Positive_regulation ADAM5 MMP28 24244825 205554 Positive_regulation ADAM5 MMP7 24244825 205569 Positive_regulation ADAM6 HBEGF 21179550 2489141 Positive_regulation ADAM6 MMP28 24244825 205576 Positive_regulation ADAM6 MMP7 24244825 205591 Positive_regulation ADAM7 HBEGF 21179550 2489143 Positive_regulation ADAM7 MMP28 24244825 205598 Positive_regulation ADAM7 MMP7 24244825 205613 Positive_regulation ADAM8 HBEGF 21179550 2489145 Positive_regulation ADAM8 MMP28 24244825 205620 Positive_regulation ADAM8 MMP7 24244825 205635 Positive_regulation ADAM9 HBEGF 21179550 2489147 Positive_regulation ADAM9 MMP28 24244825 205642 Positive_regulation ADAM9 MMP7 24244825 205657 Positive_regulation ADAMTS1 ACAN 22493487 1201690 Positive_regulation ADAMTS1 ACP2 22363291 956425 Positive_regulation ADAMTS1 AHSA1 24275094 1054227 Positive_regulation ADAMTS1 CGA 23840095 1753420 Positive_regulation ADAMTS1 CGB8 23840095 1753419 Positive_regulation ADAMTS1 CRK 20619343 1731733 Positive_regulation ADAMTS1 EAF2 24260246 2883045 Positive_regulation ADAMTS1 EAF2 24260246 2883046 Positive_regulation ADAMTS1 ERG 20840749 257319 Positive_regulation ADAMTS1 FBLN1 21197111 1912508 Positive_regulation ADAMTS1 IL17A 23859810 694901 Positive_regulation ADAMTS1 IL17A 23977238 2839379 Positive_regulation ADAMTS1 IL17A 23977238 2839387 Positive_regulation ADAMTS1 IL17A 23977238 2839389 Positive_regulation ADAMTS1 IL17A 23977238 2839392 Positive_regulation ADAMTS1 IL17A 23977238 2839394 Positive_regulation ADAMTS1 IL1A 16919164 106553 Positive_regulation ADAMTS1 IL1A 16919164 106573 Positive_regulation ADAMTS1 IL1A 20619343 1731746 Positive_regulation ADAMTS1 IL1A 22454637 680242 Positive_regulation ADAMTS1 IL1A 24176075 1667234 Positive_regulation ADAMTS1 IL1A 25157407 3002489 Positive_regulation ADAMTS1 IL1A 25228841 1712808 Positive_regulation ADAMTS1 JUN 24275094 1054228 Positive_regulation ADAMTS1 MAPK1 20619343 1731693 Positive_regulation ADAMTS1 MAPK10 20619343 1731694 Positive_regulation ADAMTS1 MAPK11 20619343 1731695 Positive_regulation ADAMTS1 MAPK12 20619343 1731696 Positive_regulation ADAMTS1 MAPK13 20619343 1731697 Positive_regulation ADAMTS1 MAPK14 20619343 1731698 Positive_regulation ADAMTS1 MAPK15 20619343 1731692 Positive_regulation ADAMTS1 MAPK3 20619343 1731699 Positive_regulation ADAMTS1 MAPK3 24275094 1054229 Positive_regulation ADAMTS1 MAPK4 20619343 1731700 Positive_regulation ADAMTS1 MAPK6 20619343 1731701 Positive_regulation ADAMTS1 MAPK7 20619343 1731702 Positive_regulation ADAMTS1 MAPK8 20619343 1731703 Positive_regulation ADAMTS1 MAPK9 20619343 1731704 Positive_regulation ADAMTS1 NCAN 23071766 2704068 Positive_regulation ADAMTS1 OSM 16919164 106554 Positive_regulation ADAMTS1 OSM 16919164 106574 Positive_regulation ADAMTS1 PGF 20840749 257310 Positive_regulation ADAMTS1 PGF 20840749 257311 Positive_regulation ADAMTS1 PGF 20840749 257314 Positive_regulation ADAMTS1 PGF 20840749 257316 Positive_regulation ADAMTS1 PGF 20840749 257317 Positive_regulation ADAMTS1 PGF 20840749 257320 Positive_regulation ADAMTS1 POLDIP2 24275094 1054284 Positive_regulation ADAMTS1 SETD2 24213506 500385 Positive_regulation ADAMTS1 TNFSF15 23859810 694900 Positive_regulation ADAMTS1 VEGFA 23289900 1867411 Positive_regulation ADAMTS1 VEGFA 24213506 500393 Positive_regulation ADAMTS1 VEGFA 24732590 2952157 Positive_regulation ADAMTS1 WNT1 23856044 128717 Positive_regulation ADAMTS1 WNT11 23856044 128718 Positive_regulation ADAMTS1 WNT16 23856044 128723 Positive_regulation ADAMTS1 WNT2 23856044 128719 Positive_regulation ADAMTS1 WNT3 23856044 128720 Positive_regulation ADAMTS1 WNT4 23856044 128721 Positive_regulation ADAMTS1 WNT6 23856044 128722 Positive_regulation ADAMTS12 TNF 24876675 1758962 Positive_regulation ADAMTS18 TNF 24213506 500389 Positive_regulation ADAMTS4 TNF 17177994 107701 Positive_regulation ADAMTS4 TNF 17177994 107704 Positive_regulation ADAMTS4 TNF 17177994 107712 Positive_regulation ADAMTS4 TNF 19435506 113288 Positive_regulation ADAMTS4 TNF 23859810 694905 Positive_regulation ADAMTS4 TNF 24176075 1667254 Positive_regulation ADAMTS4 TNF 24595230 2930863 Positive_regulation ADAMTS4 TNF 25606593 133992 Positive_regulation ADAMTS5 TNF 17177994 107702 Positive_regulation ADAMTS5 TNF 17177994 107706 Positive_regulation ADAMTS5 TNF 25606593 133984 Positive_regulation ADAMTS7 TNF 24876675 1758964 Positive_regulation ADAMTS7 TNF 25133350 139378 Positive_regulation ADAMTS9 TNF 24213506 500388 Positive_regulation ADC TNF 1740664 1545111 Positive_regulation ADCY1 ADRB2 23229733 1140545 Positive_regulation ADCY1 GLP1R 21747826 831766 Positive_regulation ADCY1 GLP1R 22111033 730310 Positive_regulation ADCY1 GLP1R 22761607 833178 Positive_regulation ADCY1 GPR115 20862379 1216356 Positive_regulation ADCY1 GPR115 22384111 2604420 Positive_regulation ADCY1 GPR132 20862379 1216345 Positive_regulation ADCY1 GPR132 22384111 2604409 Positive_regulation ADCY1 GPR87 20862379 1216425 Positive_regulation ADCY1 GPR87 22384111 2604489 Positive_regulation ADCY1 PTGER2 20948178 3079145 Positive_regulation ADCY1 PTGER2 21681585 1615964 Positive_regulation ADCY1 PTGER2 22012553 494188 Positive_regulation ADCY1 PTGER2 22505934 1067631 Positive_regulation ADCY1 PTGER2 22522619 722669 Positive_regulation ADCY10 ADRB2 23229733 1140544 Positive_regulation ADCY10 GLP1R 21747826 831765 Positive_regulation ADCY10 GLP1R 22111033 730309 Positive_regulation ADCY10 GLP1R 22761607 833177 Positive_regulation ADCY10 GPR115 20862379 1216263 Positive_regulation ADCY10 GPR115 22384111 2604327 Positive_regulation ADCY10 GPR132 20862379 1216252 Positive_regulation ADCY10 GPR132 22384111 2604316 Positive_regulation ADCY10 GPR87 20862379 1216332 Positive_regulation ADCY10 GPR87 22384111 2604396 Positive_regulation ADCY10 PTGER2 20948178 3079143 Positive_regulation ADCY10 PTGER2 21681585 1615962 Positive_regulation ADCY10 PTGER2 22012553 494186 Positive_regulation ADCY10 PTGER2 22505934 1067630 Positive_regulation ADCY10 PTGER2 22522619 722667 Positive_regulation ADCY2 ADRB2 23229733 1140546 Positive_regulation ADCY2 GLP1R 21747826 831767 Positive_regulation ADCY2 GLP1R 22111033 730311 Positive_regulation ADCY2 GLP1R 22761607 833179 Positive_regulation ADCY2 GPR115 20862379 1216449 Positive_regulation ADCY2 GPR115 22384111 2604513 Positive_regulation ADCY2 GPR132 20862379 1216438 Positive_regulation ADCY2 GPR132 22384111 2604502 Positive_regulation ADCY2 GPR87 20862379 1216518 Positive_regulation ADCY2 GPR87 22384111 2604582 Positive_regulation ADCY2 PTGER2 20948178 3079147 Positive_regulation ADCY2 PTGER2 21681585 1615966 Positive_regulation ADCY2 PTGER2 22012553 494190 Positive_regulation ADCY2 PTGER2 22505934 1067632 Positive_regulation ADCY2 PTGER2 22522619 722671 Positive_regulation ADCY3 ADRB2 23229733 1140547 Positive_regulation ADCY3 GLP1R 21747826 831768 Positive_regulation ADCY3 GLP1R 22111033 730312 Positive_regulation ADCY3 GLP1R 22761607 833180 Positive_regulation ADCY3 GPR115 20862379 1216542 Positive_regulation ADCY3 GPR115 22384111 2604606 Positive_regulation ADCY3 GPR132 20862379 1216531 Positive_regulation ADCY3 GPR132 22384111 2604595 Positive_regulation ADCY3 GPR87 20862379 1216611 Positive_regulation ADCY3 GPR87 22384111 2604675 Positive_regulation ADCY3 PTGER2 20948178 3079149 Positive_regulation ADCY3 PTGER2 21681585 1615968 Positive_regulation ADCY3 PTGER2 22012553 494192 Positive_regulation ADCY3 PTGER2 22505934 1067633 Positive_regulation ADCY3 PTGER2 22522619 722673 Positive_regulation ADCY4 ADRB2 23229733 1140548 Positive_regulation ADCY4 GLP1R 21747826 831769 Positive_regulation ADCY4 GLP1R 22111033 730313 Positive_regulation ADCY4 GLP1R 22761607 833181 Positive_regulation ADCY4 GPR115 20862379 1216635 Positive_regulation ADCY4 GPR115 22384111 2604699 Positive_regulation ADCY4 GPR132 20862379 1216624 Positive_regulation ADCY4 GPR132 22384111 2604688 Positive_regulation ADCY4 GPR87 20862379 1216704 Positive_regulation ADCY4 GPR87 22384111 2604768 Positive_regulation ADCY4 PTGER2 20948178 3079151 Positive_regulation ADCY4 PTGER2 21681585 1615970 Positive_regulation ADCY4 PTGER2 22012553 494194 Positive_regulation ADCY4 PTGER2 22505934 1067634 Positive_regulation ADCY4 PTGER2 22522619 722675 Positive_regulation ADCY5 ADRB2 23229733 1140549 Positive_regulation ADCY5 GLP1R 21747826 831770 Positive_regulation ADCY5 GLP1R 22111033 730314 Positive_regulation ADCY5 GLP1R 22761607 833182 Positive_regulation ADCY5 GPR115 20862379 1216728 Positive_regulation ADCY5 GPR115 22384111 2604792 Positive_regulation ADCY5 GPR132 20862379 1216717 Positive_regulation ADCY5 GPR132 22384111 2604781 Positive_regulation ADCY5 GPR87 20862379 1216797 Positive_regulation ADCY5 GPR87 22384111 2604861 Positive_regulation ADCY5 PTGER2 20948178 3079153 Positive_regulation ADCY5 PTGER2 21681585 1615972 Positive_regulation ADCY5 PTGER2 22012553 494196 Positive_regulation ADCY5 PTGER2 22505934 1067635 Positive_regulation ADCY5 PTGER2 22522619 722677 Positive_regulation ADCY6 ADRB2 23229733 1140550 Positive_regulation ADCY6 GLP1R 21747826 831771 Positive_regulation ADCY6 GLP1R 22111033 730315 Positive_regulation ADCY6 GLP1R 22761607 833183 Positive_regulation ADCY6 GPR115 20862379 1216821 Positive_regulation ADCY6 GPR115 22384111 2604885 Positive_regulation ADCY6 GPR132 20862379 1216810 Positive_regulation ADCY6 GPR132 22384111 2604874 Positive_regulation ADCY6 GPR87 20862379 1216890 Positive_regulation ADCY6 GPR87 22384111 2604954 Positive_regulation ADCY6 PTGER2 20948178 3079155 Positive_regulation ADCY6 PTGER2 21681585 1615974 Positive_regulation ADCY6 PTGER2 22012553 494198 Positive_regulation ADCY6 PTGER2 22505934 1067636 Positive_regulation ADCY6 PTGER2 22522619 722679 Positive_regulation ADCY7 ADRB2 23229733 1140551 Positive_regulation ADCY7 GLP1R 21747826 831772 Positive_regulation ADCY7 GLP1R 22111033 730316 Positive_regulation ADCY7 GLP1R 22761607 833184 Positive_regulation ADCY7 GPR115 20862379 1216914 Positive_regulation ADCY7 GPR115 22384111 2604978 Positive_regulation ADCY7 GPR132 20862379 1216903 Positive_regulation ADCY7 GPR132 22384111 2604967 Positive_regulation ADCY7 GPR87 20862379 1216983 Positive_regulation ADCY7 GPR87 22384111 2605047 Positive_regulation ADCY7 PTGER2 20948178 3079157 Positive_regulation ADCY7 PTGER2 21681585 1615976 Positive_regulation ADCY7 PTGER2 22012553 494200 Positive_regulation ADCY7 PTGER2 22505934 1067637 Positive_regulation ADCY7 PTGER2 22522619 722681 Positive_regulation ADCY8 ADRB2 23229733 1140552 Positive_regulation ADCY8 GLP1R 21747826 831773 Positive_regulation ADCY8 GLP1R 22111033 730317 Positive_regulation ADCY8 GLP1R 22761607 833185 Positive_regulation ADCY8 GPR115 20862379 1217007 Positive_regulation ADCY8 GPR115 22384111 2605071 Positive_regulation ADCY8 GPR132 20862379 1216996 Positive_regulation ADCY8 GPR132 22384111 2605060 Positive_regulation ADCY8 GPR87 20862379 1217076 Positive_regulation ADCY8 GPR87 22384111 2605140 Positive_regulation ADCY8 PTGER2 20948178 3079159 Positive_regulation ADCY8 PTGER2 21681585 1615978 Positive_regulation ADCY8 PTGER2 22012553 494202 Positive_regulation ADCY8 PTGER2 22505934 1067638 Positive_regulation ADCY8 PTGER2 22522619 722683 Positive_regulation ADCY9 ADRB2 23229733 1140553 Positive_regulation ADCY9 GLP1R 21747826 831774 Positive_regulation ADCY9 GLP1R 22111033 730318 Positive_regulation ADCY9 GLP1R 22761607 833186 Positive_regulation ADCY9 GPR115 20862379 1217100 Positive_regulation ADCY9 GPR115 22384111 2605164 Positive_regulation ADCY9 GPR132 20862379 1217089 Positive_regulation ADCY9 GPR132 22384111 2605153 Positive_regulation ADCY9 GPR87 20862379 1217169 Positive_regulation ADCY9 GPR87 22384111 2605233 Positive_regulation ADCY9 PTGER2 20948178 3079161 Positive_regulation ADCY9 PTGER2 21681585 1615980 Positive_regulation ADCY9 PTGER2 22012553 494204 Positive_regulation ADCY9 PTGER2 22505934 1067639 Positive_regulation ADCY9 PTGER2 22522619 722685 Positive_regulation ADH4 ADH1C 20617019 1075640 Positive_regulation ADH4 ADH1C 20617019 1075658 Positive_regulation ADH4 ADH1C 22164338 1079050 Positive_regulation ADH5 ADH1C 20617019 1075642 Positive_regulation ADH5 ADH1C 20617019 1075660 Positive_regulation ADH5 ADH1C 22164338 1079052 Positive_regulation ADH6 ADH1C 20617019 1075644 Positive_regulation ADH6 ADH1C 20617019 1075662 Positive_regulation ADH6 ADH1C 22164338 1079054 Positive_regulation ADH7 ADH1C 20617019 1075646 Positive_regulation ADH7 ADH1C 20617019 1075664 Positive_regulation ADH7 ADH1C 22164338 1079056 Positive_regulation ADIPOQ EPHB2 23424645 2755045 Positive_regulation ADIPOQ EPHB2 23424645 2755068 Positive_regulation ADIPOQ EPHB2 23424645 2755072 Positive_regulation ADIPOQ MMP28 21194467 121274 Positive_regulation ADIPOQ MMP7 21194467 121290 Positive_regulation ADIPOQ PGC 22415879 721846 Positive_regulation ADIPOQ PGC 22415879 721847 Positive_regulation ADIPOQ PGC 22415879 722310 Positive_regulation ADIPOQ TNF 15689240 2112207 Positive_regulation ADIPOQ TNF 22509348 2618750 Positive_regulation ADIPOQ TNF 22509348 2618751 Positive_regulation ADIPOQ TNF 22977686 2115234 Positive_regulation ADIPOQ TNF 23381555 1140579 Positive_regulation ADIPOQ TNF 24369466 1073875 Positive_regulation ADIPOQ TNF 24416415 2908732 Positive_regulation ADIPOQ TNF 24416415 2908752 Positive_regulation ADIPOR1 PGC 21712952 2531438 Positive_regulation ADM MMP7 22359542 2597575 Positive_regulation ADM TNF 23918941 1407104 Positive_regulation ADM TNF 23918941 1407105 Positive_regulation ADO NT5E 18404494 3088440 Positive_regulation ADORA3 TNF 22682496 126134 Positive_regulation ADRB1 ADRB2 17570158 395251 Positive_regulation ADRB2 ADRB2 17570158 395252 Positive_regulation ADRB2 BDNF 15784142 1695144 Positive_regulation ADRB2 CREB1 25195734 153414 Positive_regulation ADRB2 EZH2 21532618 2139352 Positive_regulation ADRB2 GPRC5B 18442421 1043604 Positive_regulation ADRB2 STS 21179213 2487552 Positive_regulation ADRB2 TYR 22073124 2569277 Positive_regulation ADRB2 VEGFA 21517962 6680 Positive_regulation ADRB3 ADRB2 17570158 395253 Positive_regulation ADRBK1 CAPN8 24265619 962814 Positive_regulation ADRBK1 EPHB2 24265619 962818 Positive_regulation ADRBK1 EPHB2 24597858 1650572 Positive_regulation ADRBK1 EPHB2 24755316 784545 Positive_regulation AFF1 ALOX5 25402609 2160739 Positive_regulation AGA TNF 21317295 717818 Positive_regulation AGA TNF 21317295 717819 Positive_regulation AGA TNF 21317295 717932 Positive_regulation AGER EPHB2 22449800 1718314 Positive_regulation AGO2 PGC 22655115 2224224 Positive_regulation AGO2 PGC 22655115 2224229 Positive_regulation AGO2 TP63 20485546 2450381 Positive_regulation AGR2 AHR 23635006 473266 Positive_regulation AGR2 AREG 22605983 1095654 Positive_regulation AGR2 AREG 23635006 473255 Positive_regulation AGR2 AREG 25111734 2996331 Positive_regulation AGR2 CARD11 23129749 1569850 Positive_regulation AGR2 CD4 21143974 354180 Positive_regulation AGR2 CDKN1A 8228821 1594588 Positive_regulation AGR2 CTSB 24717913 2950417 Positive_regulation AGR2 CTSD 24717913 2950418 Positive_regulation AGR2 CYP19A1 23635006 473302 Positive_regulation AGR2 ERN1 24914235 1419733 Positive_regulation AGR2 HSP90AA1 23635006 473258 Positive_regulation AGR2 IL13 22518155 1143433 Positive_regulation AGR2 OTX2 24570397 171382 Positive_regulation AGR2 RASA1 8228821 1594589 Positive_regulation AGR2 SHH 23213390 168084 Positive_regulation AGR2 SMAD4 22945649 2148352 Positive_regulation AGR2 SMAD4 22945649 2148396 Positive_regulation AGR2 SOX2 20011520 2433314 Positive_regulation AGR2 SPDEF 23650437 1572116 Positive_regulation AGRP FOXO1 17684549 2377528 Positive_regulation AGRP FOXO1 23462798 733738 Positive_regulation AGRP FOXO1 23462798 733739 Positive_regulation AGRP FOXO1 23462798 733748 Positive_regulation AGRP FOXO1 23462798 733753 Positive_regulation AGRP FOXO1 23579596 937977 Positive_regulation AGRP FOXO1 23579596 938036 Positive_regulation AGRP FOXO1 23579596 938037 Positive_regulation AGRP FOXO1 24567900 1887700 Positive_regulation AGRP FOXO1 24798184 3141732 Positive_regulation AGRP FOXO1 25343030 848252 Positive_regulation AGRP FOXO1 25610880 1496874 Positive_regulation AGRP FOXO1 25610880 1496876 Positive_regulation AGRP IRS4 24567904 1887802 Positive_regulation AGT TNF 22500179 1143841 Positive_regulation AGTR1 EPHB2 24597858 1650573 Positive_regulation AGTR1 TNF 22815633 1914675 Positive_regulation AGTR2 LAMB3 24379661 1138008 Positive_regulation AGTR2 PGC 22013433 3075746 Positive_regulation AGTR2 TNFSF10 21237154 828996 Positive_regulation AGTR2 TNNT2 25134966 1234505 Positive_regulation AGXT TNF 23251471 2728663 Positive_regulation AHR AGR2 23635006 473267 Positive_regulation AHR CAPN8 25068070 1242137 Positive_regulation AHR CAPN8 25068070 1242163 Positive_regulation AHR EDN2 24117726 34100 Positive_regulation AHR EDN2 24117726 34112 Positive_regulation AHR FAS 21858153 2546663 Positive_regulation AHR FAS 23533402 1693730 Positive_regulation AHR FLG 24161567 1492787 Positive_regulation AHR MMP28 22500183 1156055 Positive_regulation AHR MMP7 22500183 1156070 Positive_regulation AHR MUC16 22500183 1156117 Positive_regulation AHR SELL 21437035 1162382 Positive_regulation AHR TLR7 19703987 1556065 Positive_regulation AHR TLR7 22355412 2597545 Positive_regulation AHR TLR7 25089623 2994583 Positive_regulation AHR TNF 20053303 118074 Positive_regulation AHR TNF 22500183 1156050 Positive_regulation AHR TNF 23056561 2702264 Positive_regulation AHR TNF 24312355 2888938 Positive_regulation AHR TNF 24905409 1127401 Positive_regulation AHR TNF 25360137 914912 Positive_regulation AHSA1 ABCG2 25111504 2996236 Positive_regulation AHSA1 CAPN8 24416390 2908279 Positive_regulation AHSA1 CST6 21253577 3050803 Positive_regulation AHSA1 CTGF 23227240 2725754 Positive_regulation AHSA1 CTGF 23227240 2725765 Positive_regulation AHSA1 EPHB2 17425807 320189 Positive_regulation AHSA1 EPHB2 17425807 320190 Positive_regulation AHSA1 EPHB2 19727076 1983906 Positive_regulation AHSA1 EPHB2 19765281 117157 Positive_regulation AHSA1 EPHB2 21738764 2533744 Positive_regulation AHSA1 EPHB2 23150750 2225143 Positive_regulation AHSA1 EPHB2 23389627 1811942 Positive_regulation AHSA1 EPHB2 24008724 1142101 Positive_regulation AHSA1 EPHB2 25374757 82619 Positive_regulation AHSA1 EPHB2 25502694 3033846 Positive_regulation AHSA1 FAS 16818723 1330941 Positive_regulation AHSA1 FAS 21975294 552993 Positive_regulation AHSA1 FAS 9362518 1464828 Positive_regulation AHSA1 FAS 9362518 1464842 Positive_regulation AHSA1 HBEGF 22259731 1146095 Positive_regulation AHSA1 IL1B 25543336 32372 Positive_regulation AHSA1 MAP2K6 19727076 1983912 Positive_regulation AHSA1 MAP2K6 20300552 1672037 Positive_regulation AHSA1 MAP2K6 20955562 120526 Positive_regulation AHSA1 MAP2K6 20955562 120637 Positive_regulation AHSA1 MAP2K6 22175015 1686878 Positive_regulation AHSA1 MAP2K6 9314533 1463471 Positive_regulation AHSA1 MIP 17233909 351788 Positive_regulation AHSA1 PGC 25367151 133794 Positive_regulation AHSA1 STK39 20187982 328573 Positive_regulation AHSA1 TLR7 21064192 775646 Positive_regulation AHSA1 TLR7 21488180 3232637 Positive_regulation AHSA1 TLR7 23554538 3669 Positive_regulation AHSA1 TLR7 25076949 913590 Positive_regulation AHSA1 TNF 11136824 1518295 Positive_regulation AHSA1 TNF 15781582 1535121 Positive_regulation AHSA1 TNF 18591389 706354 Positive_regulation AHSA1 TNF 19594939 313131 Positive_regulation AHSA1 TNF 19723340 1227371 Positive_regulation AHSA1 TNF 20070884 1852889 Positive_regulation AHSA1 TNF 20070884 1852900 Positive_regulation AHSA1 TNF 20070884 1852903 Positive_regulation AHSA1 TNF 20087353 434403 Positive_regulation AHSA1 TNF 20955562 120495 Positive_regulation AHSA1 TNF 21607062 950200 Positive_regulation AHSA1 TNF 22313861 3160899 Positive_regulation AHSA1 TNF 22720116 2224475 Positive_regulation AHSA1 TNF 23331383 1675459 Positive_regulation AHSA1 TNF 23401658 1915578 Positive_regulation AHSA1 TNF 23409033 2753311 Positive_regulation AHSA1 TNF 23437179 2755909 Positive_regulation AHSA1 TNF 23835476 611278 Positive_regulation AHSA1 TNF 24086560 2854643 Positive_regulation AHSA1 TNF 24707477 188414 Positive_regulation AHSA1 TNF 24707477 188415 Positive_regulation AHSA1 TNF 24707477 188458 Positive_regulation AHSA1 TNF 24743742 573775 Positive_regulation AHSA1 TNF 24743742 573776 Positive_regulation AHSA1 TNF 24743742 573860 Positive_regulation AHSA1 TNF 24743742 574027 Positive_regulation AHSA1 TNF 24743742 574028 Positive_regulation AHSA1 TNF 25002903 826395 Positive_regulation AHSA1 TNF 25566431 1498386 Positive_regulation AHSA1 TNFSF10 20062539 2436814 Positive_regulation AHSG TNF 18335040 2386931 Positive_regulation AHSG TNF 18335040 2386941 Positive_regulation AICDA FOXO1 18978794 1951886 Positive_regulation AICDA FOXO1 18978794 1951908 Positive_regulation AICDA TLR7 22473011 1933699 Positive_regulation AICDA TNF 23536776 2771515 Positive_regulation AIF1 TCN1 24735601 1667969 Positive_regulation AIF1 TCN1 24735601 1667982 Positive_regulation AIF1 TCN1 24735601 1667999 Positive_regulation AIF1 TNF 21317295 717901 Positive_regulation AIMP1 TNF 22140588 2371117 Positive_regulation AIRE EPHB2 21364986 2504704 Positive_regulation AIRE MAP2K6 21364986 2504711 Positive_regulation AIS1 NFASC 21382554 2010195 Positive_regulation AIS1 NFASC 21382554 2010200 Positive_regulation AIS2 NFASC 21382554 2010196 Positive_regulation AIS2 NFASC 21382554 2010201 Positive_regulation AIS3 NFASC 21382554 2010197 Positive_regulation AIS3 NFASC 21382554 2010202 Positive_regulation AKAP9 NES 15251038 277801 Positive_regulation AKR1B1 MYH16 19341503 1020530 Positive_regulation AKR1B1 MYH3 19341503 1020537 Positive_regulation AKR1B1 TNF 14630568 830289 Positive_regulation AKR1B1 TNF 25126080 965773 Positive_regulation AKT1 ABCG2 24603487 2931888 Positive_regulation AKT1 ABCG2 24603487 2931895 Positive_regulation AKT1 ALOX5 21297225 2174767 Positive_regulation AKT1 ANGPT1 18835934 707027 Positive_regulation AKT1 ANGPT1 19435476 659227 Positive_regulation AKT1 ANGPT1 21113176 12121 Positive_regulation AKT1 ANGPT1 21179479 2488300 Positive_regulation AKT1 ANGPT1 21779348 2536801 Positive_regulation AKT1 ANGPT1 22454630 832618 Positive_regulation AKT1 ANGPT1 22454630 832619 Positive_regulation AKT1 ANGPT1 22454630 832635 Positive_regulation AKT1 ANGPT1 22454630 832641 Positive_regulation AKT1 ANGPT1 22454630 832663 Positive_regulation AKT1 ANGPT1 22611498 1145658 Positive_regulation AKT1 ANGPT1 22792187 2661141 Positive_regulation AKT1 ANGPT1 23554782 1226212 Positive_regulation AKT1 ANGPT1 23653322 780692 Positive_regulation AKT1 ANGPT1 24013716 2842132 Positive_regulation AKT1 ANGPT1 24459518 746242 Positive_regulation AKT1 ANGPT1 25329960 3017078 Positive_regulation AKT1 ANGPT1 25371820 1690104 Positive_regulation AKT1 ARSA 19966835 8439 Positive_regulation AKT1 AXIN2 20578217 1237702 Positive_regulation AKT1 BPI 17060474 1543049 Positive_regulation AKT1 C1QTNF1 24827430 2969823 Positive_regulation AKT1 CAPN8 23425388 275486 Positive_regulation AKT1 CAPN8 23425388 275487 Positive_regulation AKT1 CAPN8 23425388 275704 Positive_regulation AKT1 CCND1 20049173 1671592 Positive_regulation AKT1 CCND1 21297902 496668 Positive_regulation AKT1 CCND1 22799881 265310 Positive_regulation AKT1 CCND1 24348821 2167421 Positive_regulation AKT1 CCND1 25047753 240833 Positive_regulation AKT1 CEACAM6 25398131 3027582 Positive_regulation AKT1 CHI3L1 19414556 1554751 Positive_regulation AKT1 CHI3L1 20224674 35539 Positive_regulation AKT1 CHI3L1 23840582 2815323 Positive_regulation AKT1 CHI3L1 23972995 608981 Positive_regulation AKT1 CHI3L1 23972995 608982 Positive_regulation AKT1 CHI3L1 23972995 609012 Positive_regulation AKT1 CHI3L1 24281168 501789 Positive_regulation AKT1 CLU 24156019 492156 Positive_regulation AKT1 CTGF 19152120 1478378 Positive_regulation AKT1 CTGF 21760921 2536009 Positive_regulation AKT1 CTGF 22491319 1933891 Positive_regulation AKT1 CTGF 23208610 1478671 Positive_regulation AKT1 CTGF 23208610 1478674 Positive_regulation AKT1 CTGF 23208610 1478677 Positive_regulation AKT1 CTGF 23755163 2801567 Positive_regulation AKT1 CTGF 25478966 3032185 Positive_regulation AKT1 DAPK1 24710474 618142 Positive_regulation AKT1 EDN2 24523730 3077089 Positive_regulation AKT1 EFNB1 22879882 2672849 Positive_regulation AKT1 EFNB1 23764850 562394 Positive_regulation AKT1 EPHB2 17915029 384373 Positive_regulation AKT1 EPHB2 18004277 1902404 Positive_regulation AKT1 EPHB2 18091994 2381397 Positive_regulation AKT1 EPHB2 18091994 2381403 Positive_regulation AKT1 EPHB2 18430238 247531 Positive_regulation AKT1 EPHB2 18852899 2397603 Positive_regulation AKT1 EPHB2 19039330 545809 Positive_regulation AKT1 EPHB2 20520761 2451881 Positive_regulation AKT1 EPHB2 20532039 2452212 Positive_regulation AKT1 EPHB2 20625388 2454931 Positive_regulation AKT1 EPHB2 20661223 2133167 Positive_regulation AKT1 EPHB2 21048967 2480315 Positive_regulation AKT1 EPHB2 21048967 2480323 Positive_regulation AKT1 EPHB2 21048967 2480330 Positive_regulation AKT1 EPHB2 22116303 438046 Positive_regulation AKT1 EPHB2 22159814 1140717 Positive_regulation AKT1 EPHB2 22254083 2116106 Positive_regulation AKT1 EPHB2 22558291 2625015 Positive_regulation AKT1 EPHB2 22649371 874955 Positive_regulation AKT1 EPHB2 22654833 876147 Positive_regulation AKT1 EPHB2 23213390 168013 Positive_regulation AKT1 EPHB2 23345981 3177038 Positive_regulation AKT1 EPHB2 23420122 2163412 Positive_regulation AKT1 EPHB2 23554919 2773878 Positive_regulation AKT1 EPHB2 23591770 3135519 Positive_regulation AKT1 EPHB2 23755222 2802110 Positive_regulation AKT1 EPHB2 23762063 1069283 Positive_regulation AKT1 EPHB2 24018888 1112429 Positive_regulation AKT1 EPHB2 24031151 3230671 Positive_regulation AKT1 EPHB2 24116164 2865623 Positive_regulation AKT1 EPHB2 24131623 270097 Positive_regulation AKT1 EPHB2 24155779 1240237 Positive_regulation AKT1 EPHB2 24168056 1700811 Positive_regulation AKT1 EPHB2 24321545 410807 Positive_regulation AKT1 EPHB2 24498405 2919619 Positive_regulation AKT1 EPHB2 24533454 271669 Positive_regulation AKT1 EPHB2 24699278 2948521 Positive_regulation AKT1 EPHB2 24721622 1679083 Positive_regulation AKT1 EPHB2 24739440 1679365 Positive_regulation AKT1 EPHB2 24744103 495047 Positive_regulation AKT1 EPHB2 24797725 2189712 Positive_regulation AKT1 EPHB2 24859236 2974817 Positive_regulation AKT1 EPHB2 24978597 2985578 Positive_regulation AKT1 EPHB2 25019090 1496469 Positive_regulation AKT1 EPHB2 25019090 1496470 Positive_regulation AKT1 EPHB2 25295009 966013 Positive_regulation AKT1 F2R 23236426 2726347 Positive_regulation AKT1 F2R 23239877 1205872 Positive_regulation AKT1 F2R 24385683 1756404 Positive_regulation AKT1 FAS 11121444 1265870 Positive_regulation AKT1 FAS 22824368 1724875 Positive_regulation AKT1 FAS 22824368 1724882 Positive_regulation AKT1 FHL1 24952875 274082 Positive_regulation AKT1 FOXO1 17997602 3040240 Positive_regulation AKT1 FOXO1 19108710 324548 Positive_regulation AKT1 FOXO1 20007934 712129 Positive_regulation AKT1 FOXO1 20139898 8980 Positive_regulation AKT1 FOXO1 20375467 26929 Positive_regulation AKT1 FOXO1 21295499 1040422 Positive_regulation AKT1 FOXO1 21335550 1190772 Positive_regulation AKT1 FOXO1 22312004 1395038 Positive_regulation AKT1 FOXO1 22649777 939926 Positive_regulation AKT1 FOXO1 23268536 740201 Positive_regulation AKT1 FOXO1 24015318 2842820 Positive_regulation AKT1 FOXO1 24490110 3151527 Positive_regulation AKT1 FOXO1 25271153 1211022 Positive_regulation AKT1 FUT4 23887626 564154 Positive_regulation AKT1 FUT4 23887626 564160 Positive_regulation AKT1 GAB3 16009726 1321433 Positive_regulation AKT1 GAB3 23805312 2808417 Positive_regulation AKT1 GLP1R 24843641 1494460 Positive_regulation AKT1 GPNMB 22891158 3131107 Positive_regulation AKT1 HBEGF 19470173 1503694 Positive_regulation AKT1 HBEGF 19935697 2128260 Positive_regulation AKT1 HBEGF 22496644 3056073 Positive_regulation AKT1 HBEGF 22873932 533018 Positive_regulation AKT1 HBEGF 24136232 568207 Positive_regulation AKT1 HES2 22004682 1863775 Positive_regulation AKT1 HES2 22004682 1863828 Positive_regulation AKT1 ID1 22139302 1879320 Positive_regulation AKT1 ID1 22139302 1879353 Positive_regulation AKT1 ID1 22139302 1879381 Positive_regulation AKT1 ID1 22139302 1879388 Positive_regulation AKT1 ID1 24970809 2193991 Positive_regulation AKT1 IFI27 21841827 2141883 Positive_regulation AKT1 IFI27 21841827 2141884 Positive_regulation AKT1 IFI27 23383273 2749913 Positive_regulation AKT1 INPP4B 21487159 2175787 Positive_regulation AKT1 INPP4B 22895072 478780 Positive_regulation AKT1 INPP4B 22895072 478795 Positive_regulation AKT1 INPP4B 24500884 492408 Positive_regulation AKT1 INPP4B 25126743 2997993 Positive_regulation AKT1 INPP4B 25542038 3036102 Positive_regulation AKT1 LAMB3 22673183 471573 Positive_regulation AKT1 LBP 25045414 2229622 Positive_regulation AKT1 MAP2K6 12838322 422759 Positive_regulation AKT1 MAP2K6 14577832 3095159 Positive_regulation AKT1 MAP2K6 18159242 2381551 Positive_regulation AKT1 MAP2K6 19917087 1676313 Positive_regulation AKT1 MAP2K6 20634980 2455746 Positive_regulation AKT1 MAP2K6 22854065 625051 Positive_regulation AKT1 MAP2K6 23112573 1915227 Positive_regulation AKT1 MAP2K6 23300886 2737063 Positive_regulation AKT1 MAP2K6 23300886 2737120 Positive_regulation AKT1 MAP2K6 24031151 3230677 Positive_regulation AKT1 MAP2K6 24036604 2184795 Positive_regulation AKT1 MAP2K6 24937142 851320 Positive_regulation AKT1 MAP2K6 24970815 2194387 Positive_regulation AKT1 MAP2K6 24978597 2985584 Positive_regulation AKT1 MMP28 22860018 2670936 Positive_regulation AKT1 MMP28 25421240 1135197 Positive_regulation AKT1 MMP7 22860018 2670951 Positive_regulation AKT1 MMP7 25421240 1135212 Positive_regulation AKT1 MUC16 23694968 3135782 Positive_regulation AKT1 NES 21682918 1862502 Positive_regulation AKT1 NGFR 21364635 549676 Positive_regulation AKT1 NGFR 22880054 2673799 Positive_regulation AKT1 NGFR 22880054 2673848 Positive_regulation AKT1 NGFR 22880054 2673849 Positive_regulation AKT1 NGFR 22880054 2673956 Positive_regulation AKT1 NNMT 23764850 562407 Positive_regulation AKT1 PECAM1 22724015 2655551 Positive_regulation AKT1 PGC 21629705 1155259 Positive_regulation AKT1 PLAT 23936774 182561 Positive_regulation AKT1 PLAT 25514242 1135682 Positive_regulation AKT1 PTGER2 19801995 8140 Positive_regulation AKT1 PTGER2 23575689 1935989 Positive_regulation AKT1 RCAN1 19124655 1553342 Positive_regulation AKT1 RGS16 25568667 987496 Positive_regulation AKT1 RGS2 25309327 871488 Positive_regulation AKT1 S1PR3 21887342 2549402 Positive_regulation AKT1 SLC28A1 23722537 562004 Positive_regulation AKT1 SLC28A1 23722537 562023 Positive_regulation AKT1 SPHK1 21625639 2525218 Positive_regulation AKT1 SPHK1 21625639 2525227 Positive_regulation AKT1 SPHK1 21625639 2525235 Positive_regulation AKT1 SPHK1 23732709 2156791 Positive_regulation AKT1 SPHK1 23732709 2156792 Positive_regulation AKT1 SPHK1 25109605 2171858 Positive_regulation AKT1 SPHK1 25109605 2171859 Positive_regulation AKT1 STK39 22402981 93062 Positive_regulation AKT1 STK39 24967401 193223 Positive_regulation AKT1 TCN1 20489726 546991 Positive_regulation AKT1 TCN1 20489726 547011 Positive_regulation AKT1 TCN1 20489726 547038 Positive_regulation AKT1 TGM2 22225906 469615 Positive_regulation AKT1 TLR7 15280422 1533127 Positive_regulation AKT1 TLR7 18227218 1548865 Positive_regulation AKT1 TLR7 22145029 2577296 Positive_regulation AKT1 TLR7 23166614 2718084 Positive_regulation AKT1 TLR7 24367261 3065405 Positive_regulation AKT1 TLR7 24740015 2953738 Positive_regulation AKT1 TLR7 24740015 2953739 Positive_regulation AKT1 TLR7 24740015 2954036 Positive_regulation AKT1 TM4SF19 25344917 2206174 Positive_regulation AKT1 TNF 11238593 1519018 Positive_regulation AKT1 TNF 15841081 425861 Positive_regulation AKT1 TNF 16872509 3107513 Positive_regulation AKT1 TNF 18443205 705802 Positive_regulation AKT1 TNF 19118493 651006 Positive_regulation AKT1 TNF 20482767 118970 Positive_regulation AKT1 TNF 20482767 118978 Positive_regulation AKT1 TNF 20836895 1657157 Positive_regulation AKT1 TNF 20836895 1657160 Positive_regulation AKT1 TNF 21386087 718466 Positive_regulation AKT1 TNF 21867555 1659538 Positive_regulation AKT1 TNF 21867555 1659558 Positive_regulation AKT1 TNF 21867555 1659601 Positive_regulation AKT1 TNF 22039465 2565523 Positive_regulation AKT1 TNF 22039465 2565539 Positive_regulation AKT1 TNF 22243518 1898893 Positive_regulation AKT1 TNF 22426696 14563 Positive_regulation AKT1 TNF 22426696 14566 Positive_regulation AKT1 TNF 22545132 2623892 Positive_regulation AKT1 TNF 22739986 556368 Positive_regulation AKT1 TNF 22837815 3131084 Positive_regulation AKT1 TNF 23028409 2219954 Positive_regulation AKT1 TNF 23071583 2702971 Positive_regulation AKT1 TNF 23071583 2702972 Positive_regulation AKT1 TNF 23071583 2702973 Positive_regulation AKT1 TNF 23071583 2702974 Positive_regulation AKT1 TNF 23071583 2702975 Positive_regulation AKT1 TNF 23071583 2703023 Positive_regulation AKT1 TNF 23071583 2703032 Positive_regulation AKT1 TNF 23071583 2703033 Positive_regulation AKT1 TNF 23071583 2703085 Positive_regulation AKT1 TNF 23071583 2703126 Positive_regulation AKT1 TNF 23071583 2703127 Positive_regulation AKT1 TNF 23071583 2703136 Positive_regulation AKT1 TNF 23071583 2703156 Positive_regulation AKT1 TNF 23150750 2225205 Positive_regulation AKT1 TNF 23293468 3179687 Positive_regulation AKT1 TNF 23437347 2756507 Positive_regulation AKT1 TNF 23437347 2756513 Positive_regulation AKT1 TNF 23437404 2756832 Positive_regulation AKT1 TNF 23437404 2756906 Positive_regulation AKT1 TNF 23437404 2756913 Positive_regulation AKT1 TNF 23789107 169890 Positive_regulation AKT1 TNF 24013271 2842019 Positive_regulation AKT1 TNF 24312381 2889124 Positive_regulation AKT1 TNF 24489443 1757398 Positive_regulation AKT1 TNF 24577082 572424 Positive_regulation AKT1 TNF 24586980 2928518 Positive_regulation AKT1 TNF 24586980 2928639 Positive_regulation AKT1 TNF 24669186 742931 Positive_regulation AKT1 TNF 24669186 742946 Positive_regulation AKT1 TNF 24669186 742947 Positive_regulation AKT1 TNF 24669186 742961 Positive_regulation AKT1 TNF 24676340 1087230 Positive_regulation AKT1 TNF 24714064 2949904 Positive_regulation AKT1 TNF 24868497 3179294 Positive_regulation AKT1 TNF 25114952 3156800 Positive_regulation AKT1 TNF 25114952 3156805 Positive_regulation AKT1 TNF 25114952 3156824 Positive_regulation AKT1 TNF 25132732 1760495 Positive_regulation AKT1 TNF 25162582 3002882 Positive_regulation AKT1 TNF 25162582 3002903 Positive_regulation AKT1 TNF 25162582 3002928 Positive_regulation AKT1 TNF 25162582 3002936 Positive_regulation AKT1 TNF 25162582 3002943 Positive_regulation AKT1 TNF 25352752 1917441 Positive_regulation AKT1 TNF 25352752 1917472 Positive_regulation AKT1 TNF PMC3272755 99489 Positive_regulation AKT1 TNFSF10 20839416 806598 Positive_regulation AKT1 TNFSF10 25003395 505004 Positive_regulation AKT1 TNFSF10 PMC2834064 134549 Positive_regulation AKT1 TP63 19517019 2419054 Positive_regulation AKT1 TP63 19517019 2419071 Positive_regulation AKT1 WNT7A 22179044 1928153 Positive_regulation AKT1 WNT7A 24287629 1939710 Positive_regulation AKT2 ABCG2 24603487 2931889 Positive_regulation AKT2 ABCG2 24603487 2931896 Positive_regulation AKT2 ALOX5 21297225 2174768 Positive_regulation AKT2 ANGPT1 18835934 707028 Positive_regulation AKT2 ANGPT1 19435476 659229 Positive_regulation AKT2 ANGPT1 21113176 12122 Positive_regulation AKT2 ANGPT1 21179479 2488302 Positive_regulation AKT2 ANGPT1 21779348 2536803 Positive_regulation AKT2 ANGPT1 22454630 832620 Positive_regulation AKT2 ANGPT1 22454630 832621 Positive_regulation AKT2 ANGPT1 22454630 832636 Positive_regulation AKT2 ANGPT1 22454630 832642 Positive_regulation AKT2 ANGPT1 22454630 832664 Positive_regulation AKT2 ANGPT1 22611498 1145659 Positive_regulation AKT2 ANGPT1 22792187 2661143 Positive_regulation AKT2 ANGPT1 23554782 1226213 Positive_regulation AKT2 ANGPT1 23653322 780694 Positive_regulation AKT2 ANGPT1 24013716 2842133 Positive_regulation AKT2 ANGPT1 24459518 746244 Positive_regulation AKT2 ANGPT1 25329960 3017081 Positive_regulation AKT2 ANGPT1 25371820 1690106 Positive_regulation AKT2 ARSA 19966835 8440 Positive_regulation AKT2 AXIN2 20578217 1237704 Positive_regulation AKT2 BPI 17060474 1543054 Positive_regulation AKT2 C1QTNF1 24827430 2969824 Positive_regulation AKT2 CAPN8 23425388 275514 Positive_regulation AKT2 CAPN8 23425388 275515 Positive_regulation AKT2 CAPN8 23425388 275719 Positive_regulation AKT2 CCND1 20049173 1671593 Positive_regulation AKT2 CCND1 21297902 496669 Positive_regulation AKT2 CCND1 22799881 265311 Positive_regulation AKT2 CCND1 24348821 2167422 Positive_regulation AKT2 CCND1 25047753 240849 Positive_regulation AKT2 CEACAM6 25398131 3027583 Positive_regulation AKT2 CHI3L1 19414556 1554752 Positive_regulation AKT2 CHI3L1 20224674 35540 Positive_regulation AKT2 CHI3L1 23840582 2815324 Positive_regulation AKT2 CHI3L1 23972995 608983 Positive_regulation AKT2 CHI3L1 23972995 608984 Positive_regulation AKT2 CHI3L1 23972995 609013 Positive_regulation AKT2 CHI3L1 24281168 501790 Positive_regulation AKT2 CLU 24156019 492157 Positive_regulation AKT2 CTGF 19152120 1478379 Positive_regulation AKT2 CTGF 22491319 1933894 Positive_regulation AKT2 CTGF 23208610 1478672 Positive_regulation AKT2 CTGF 23208610 1478675 Positive_regulation AKT2 CTGF 23208610 1478678 Positive_regulation AKT2 CTGF 23755163 2801568 Positive_regulation AKT2 CTGF 25478966 3032186 Positive_regulation AKT2 DAPK1 24710474 618145 Positive_regulation AKT2 EDN2 24523730 3077092 Positive_regulation AKT2 EFNB1 22879882 2672852 Positive_regulation AKT2 EFNB1 23764850 562397 Positive_regulation AKT2 EPHB2 17915029 384374 Positive_regulation AKT2 EPHB2 18004277 1902406 Positive_regulation AKT2 EPHB2 18091994 2381398 Positive_regulation AKT2 EPHB2 18091994 2381404 Positive_regulation AKT2 EPHB2 18430238 247545 Positive_regulation AKT2 EPHB2 18682746 2394865 Positive_regulation AKT2 EPHB2 18852899 2397604 Positive_regulation AKT2 EPHB2 19039330 545812 Positive_regulation AKT2 EPHB2 20520761 2451882 Positive_regulation AKT2 EPHB2 20532039 2452216 Positive_regulation AKT2 EPHB2 20625388 2454932 Positive_regulation AKT2 EPHB2 20661223 2133168 Positive_regulation AKT2 EPHB2 21048967 2480316 Positive_regulation AKT2 EPHB2 21048967 2480324 Positive_regulation AKT2 EPHB2 21048967 2480331 Positive_regulation AKT2 EPHB2 22116303 438047 Positive_regulation AKT2 EPHB2 22159814 1140722 Positive_regulation AKT2 EPHB2 22558291 2625017 Positive_regulation AKT2 EPHB2 22649371 874957 Positive_regulation AKT2 EPHB2 22654833 876149 Positive_regulation AKT2 EPHB2 23213390 168027 Positive_regulation AKT2 EPHB2 23345981 3177039 Positive_regulation AKT2 EPHB2 23420122 2163413 Positive_regulation AKT2 EPHB2 23554919 2773893 Positive_regulation AKT2 EPHB2 23591770 3135521 Positive_regulation AKT2 EPHB2 23755222 2802113 Positive_regulation AKT2 EPHB2 23762063 1069284 Positive_regulation AKT2 EPHB2 24018888 1112433 Positive_regulation AKT2 EPHB2 24031151 3230679 Positive_regulation AKT2 EPHB2 24116164 2865624 Positive_regulation AKT2 EPHB2 24131623 270100 Positive_regulation AKT2 EPHB2 24155779 1240238 Positive_regulation AKT2 EPHB2 24168056 1700814 Positive_regulation AKT2 EPHB2 24321545 410811 Positive_regulation AKT2 EPHB2 24498405 2919621 Positive_regulation AKT2 EPHB2 24533454 271671 Positive_regulation AKT2 EPHB2 24699278 2948535 Positive_regulation AKT2 EPHB2 24721622 1679087 Positive_regulation AKT2 EPHB2 24739440 1679366 Positive_regulation AKT2 EPHB2 24744103 495048 Positive_regulation AKT2 EPHB2 24797725 2189713 Positive_regulation AKT2 EPHB2 24859236 2974819 Positive_regulation AKT2 EPHB2 24978597 2985586 Positive_regulation AKT2 EPHB2 25019090 1496497 Positive_regulation AKT2 EPHB2 25019090 1496498 Positive_regulation AKT2 EPHB2 25295009 966018 Positive_regulation AKT2 F2R 23236426 2726348 Positive_regulation AKT2 F2R 24385683 1756406 Positive_regulation AKT2 FAS 11121444 1265871 Positive_regulation AKT2 FAS 22824368 1724876 Positive_regulation AKT2 FHL1 24952875 274083 Positive_regulation AKT2 FOXO1 17997602 3040242 Positive_regulation AKT2 FOXO1 19108710 324549 Positive_regulation AKT2 FOXO1 20007934 712133 Positive_regulation AKT2 FOXO1 20139898 8981 Positive_regulation AKT2 FOXO1 20375467 26933 Positive_regulation AKT2 FOXO1 21295499 1040426 Positive_regulation AKT2 FOXO1 21335550 1190773 Positive_regulation AKT2 FOXO1 22312004 1395042 Positive_regulation AKT2 FOXO1 22649777 939930 Positive_regulation AKT2 FOXO1 23268536 740202 Positive_regulation AKT2 FOXO1 24015318 2842821 Positive_regulation AKT2 FOXO1 24490110 3151528 Positive_regulation AKT2 FOXO1 25271153 1211023 Positive_regulation AKT2 FUT4 23887626 564155 Positive_regulation AKT2 FUT4 23887626 564163 Positive_regulation AKT2 GAB3 16009726 1321435 Positive_regulation AKT2 GAB3 23805312 2808421 Positive_regulation AKT2 GLP1R 24843641 1494461 Positive_regulation AKT2 HBEGF 19470173 1503696 Positive_regulation AKT2 HBEGF 19935697 2128261 Positive_regulation AKT2 HBEGF 22496644 3056074 Positive_regulation AKT2 HBEGF 22873932 533019 Positive_regulation AKT2 HBEGF 24136232 568208 Positive_regulation AKT2 HES2 22004682 1863782 Positive_regulation AKT2 HES2 22004682 1863835 Positive_regulation AKT2 ID1 22139302 1879323 Positive_regulation AKT2 ID1 22139302 1879356 Positive_regulation AKT2 ID1 22139302 1879382 Positive_regulation AKT2 ID1 22139302 1879389 Positive_regulation AKT2 ID1 24970809 2193992 Positive_regulation AKT2 IFI27 21841827 2141885 Positive_regulation AKT2 IFI27 21841827 2141886 Positive_regulation AKT2 IFI27 23383273 2749916 Positive_regulation AKT2 INPP4B 21487159 2175788 Positive_regulation AKT2 INPP4B 22895072 478781 Positive_regulation AKT2 INPP4B 22895072 478796 Positive_regulation AKT2 INPP4B 24500884 492409 Positive_regulation AKT2 INPP4B 25126743 2997994 Positive_regulation AKT2 INPP4B 25542038 3036104 Positive_regulation AKT2 LAMB3 22673183 471576 Positive_regulation AKT2 LBP 25045414 2229623 Positive_regulation AKT2 MAP2K6 12838322 422767 Positive_regulation AKT2 MAP2K6 14577832 3095181 Positive_regulation AKT2 MAP2K6 18159242 2381560 Positive_regulation AKT2 MAP2K6 18682746 2394871 Positive_regulation AKT2 MAP2K6 19917087 1676320 Positive_regulation AKT2 MAP2K6 20634980 2455755 Positive_regulation AKT2 MAP2K6 22854065 625071 Positive_regulation AKT2 MAP2K6 23112573 1915234 Positive_regulation AKT2 MAP2K6 23300886 2737071 Positive_regulation AKT2 MAP2K6 23300886 2737128 Positive_regulation AKT2 MAP2K6 24031151 3230685 Positive_regulation AKT2 MAP2K6 24036604 2184803 Positive_regulation AKT2 MAP2K6 24937142 851327 Positive_regulation AKT2 MAP2K6 24970815 2194394 Positive_regulation AKT2 MAP2K6 24978597 2985592 Positive_regulation AKT2 MMP28 22860018 2670958 Positive_regulation AKT2 MMP28 25421240 1135219 Positive_regulation AKT2 MMP7 22860018 2670973 Positive_regulation AKT2 MMP7 25421240 1135234 Positive_regulation AKT2 MUC16 23694968 3135784 Positive_regulation AKT2 NES 21682918 1862504 Positive_regulation AKT2 NGFR 21364635 549677 Positive_regulation AKT2 NGFR 22880054 2673801 Positive_regulation AKT2 NGFR 22880054 2673852 Positive_regulation AKT2 NGFR 22880054 2673853 Positive_regulation AKT2 NGFR 22880054 2673961 Positive_regulation AKT2 NNMT 23764850 562408 Positive_regulation AKT2 PECAM1 22724015 2655552 Positive_regulation AKT2 PGC 21629705 1155261 Positive_regulation AKT2 PLAT 23936774 182563 Positive_regulation AKT2 PLAT 25514242 1135683 Positive_regulation AKT2 PTGER2 19801995 8141 Positive_regulation AKT2 PTGER2 23575689 1935991 Positive_regulation AKT2 RCAN1 19124655 1553343 Positive_regulation AKT2 RGS16 25568667 987497 Positive_regulation AKT2 RGS2 25309327 871489 Positive_regulation AKT2 S1PR3 21887342 2549403 Positive_regulation AKT2 SLC28A1 23722537 562005 Positive_regulation AKT2 SLC28A1 23722537 562024 Positive_regulation AKT2 SPHK1 21625639 2525219 Positive_regulation AKT2 SPHK1 21625639 2525228 Positive_regulation AKT2 SPHK1 21625639 2525236 Positive_regulation AKT2 SPHK1 23732709 2156797 Positive_regulation AKT2 SPHK1 23732709 2156798 Positive_regulation AKT2 SPHK1 25109605 2171860 Positive_regulation AKT2 SPHK1 25109605 2171861 Positive_regulation AKT2 STK39 22402981 93079 Positive_regulation AKT2 STK39 24967401 193239 Positive_regulation AKT2 TCN1 20489726 546993 Positive_regulation AKT2 TCN1 20489726 547014 Positive_regulation AKT2 TCN1 20489726 547040 Positive_regulation AKT2 TGM2 22225906 469616 Positive_regulation AKT2 TLR7 15280422 1533137 Positive_regulation AKT2 TLR7 18227218 1548877 Positive_regulation AKT2 TLR7 22145029 2577306 Positive_regulation AKT2 TLR7 23166614 2718094 Positive_regulation AKT2 TLR7 24367261 3065415 Positive_regulation AKT2 TLR7 24740015 2953758 Positive_regulation AKT2 TLR7 24740015 2953759 Positive_regulation AKT2 TLR7 24740015 2954053 Positive_regulation AKT2 TM4SF19 25344917 2206180 Positive_regulation AKT2 TNF 11238593 1519019 Positive_regulation AKT2 TNF 15841081 425863 Positive_regulation AKT2 TNF 16872509 3107514 Positive_regulation AKT2 TNF 18443205 705805 Positive_regulation AKT2 TNF 19118493 651008 Positive_regulation AKT2 TNF 20482767 118972 Positive_regulation AKT2 TNF 20482767 118980 Positive_regulation AKT2 TNF 20836895 1657158 Positive_regulation AKT2 TNF 20836895 1657161 Positive_regulation AKT2 TNF 21386087 718481 Positive_regulation AKT2 TNF 21867555 1659539 Positive_regulation AKT2 TNF 21867555 1659559 Positive_regulation AKT2 TNF 21867555 1659602 Positive_regulation AKT2 TNF 22039465 2565524 Positive_regulation AKT2 TNF 22039465 2565540 Positive_regulation AKT2 TNF 22243518 1898894 Positive_regulation AKT2 TNF 22426696 14564 Positive_regulation AKT2 TNF 22426696 14567 Positive_regulation AKT2 TNF 22545132 2623894 Positive_regulation AKT2 TNF 22739986 556369 Positive_regulation AKT2 TNF 22837815 3131085 Positive_regulation AKT2 TNF 23028409 2219955 Positive_regulation AKT2 TNF 23071583 2702977 Positive_regulation AKT2 TNF 23071583 2702978 Positive_regulation AKT2 TNF 23071583 2702979 Positive_regulation AKT2 TNF 23071583 2702980 Positive_regulation AKT2 TNF 23071583 2702981 Positive_regulation AKT2 TNF 23071583 2703024 Positive_regulation AKT2 TNF 23071583 2703041 Positive_regulation AKT2 TNF 23071583 2703042 Positive_regulation AKT2 TNF 23071583 2703086 Positive_regulation AKT2 TNF 23071583 2703128 Positive_regulation AKT2 TNF 23071583 2703129 Positive_regulation AKT2 TNF 23071583 2703130 Positive_regulation AKT2 TNF 23071583 2703137 Positive_regulation AKT2 TNF 23071583 2703157 Positive_regulation AKT2 TNF 23150750 2225206 Positive_regulation AKT2 TNF 23293468 3179688 Positive_regulation AKT2 TNF 23437347 2756508 Positive_regulation AKT2 TNF 23437347 2756514 Positive_regulation AKT2 TNF 23437404 2756833 Positive_regulation AKT2 TNF 23437404 2756907 Positive_regulation AKT2 TNF 23437404 2756914 Positive_regulation AKT2 TNF 23789107 169891 Positive_regulation AKT2 TNF 23805905 1726149 Positive_regulation AKT2 TNF 24013271 2842020 Positive_regulation AKT2 TNF 24312381 2889125 Positive_regulation AKT2 TNF 24489443 1757399 Positive_regulation AKT2 TNF 24577082 572425 Positive_regulation AKT2 TNF 24586980 2928521 Positive_regulation AKT2 TNF 24586980 2928643 Positive_regulation AKT2 TNF 24669186 742932 Positive_regulation AKT2 TNF 24669186 742948 Positive_regulation AKT2 TNF 24669186 742949 Positive_regulation AKT2 TNF 24669186 742962 Positive_regulation AKT2 TNF 24676340 1087231 Positive_regulation AKT2 TNF 24714064 2949905 Positive_regulation AKT2 TNF 24868497 3179295 Positive_regulation AKT2 TNF 25114952 3156801 Positive_regulation AKT2 TNF 25114952 3156806 Positive_regulation AKT2 TNF 25114952 3156825 Positive_regulation AKT2 TNF 25132732 1760496 Positive_regulation AKT2 TNF 25162582 3002883 Positive_regulation AKT2 TNF 25162582 3002904 Positive_regulation AKT2 TNF 25162582 3002929 Positive_regulation AKT2 TNF 25162582 3002937 Positive_regulation AKT2 TNF 25162582 3002944 Positive_regulation AKT2 TNF 25352752 1917443 Positive_regulation AKT2 TNF 25352752 1917474 Positive_regulation AKT2 TNF PMC3272755 99490 Positive_regulation AKT2 TNFSF10 20839416 806599 Positive_regulation AKT2 TNFSF10 25003395 505005 Positive_regulation AKT2 TNFSF10 PMC2834064 134550 Positive_regulation AKT2 TP63 19517019 2419055 Positive_regulation AKT2 TP63 19517019 2419073 Positive_regulation AKT2 WNT7A 22179044 1928154 Positive_regulation AKT2 WNT7A 24287629 1939711 Positive_regulation AKT3 ABCG2 24603487 2931890 Positive_regulation AKT3 ABCG2 24603487 2931897 Positive_regulation AKT3 ALOX5 21297225 2174769 Positive_regulation AKT3 ANGPT1 18835934 707029 Positive_regulation AKT3 ANGPT1 19435476 659231 Positive_regulation AKT3 ANGPT1 21113176 12123 Positive_regulation AKT3 ANGPT1 21179479 2488304 Positive_regulation AKT3 ANGPT1 21779348 2536805 Positive_regulation AKT3 ANGPT1 22454630 832622 Positive_regulation AKT3 ANGPT1 22454630 832623 Positive_regulation AKT3 ANGPT1 22454630 832637 Positive_regulation AKT3 ANGPT1 22454630 832643 Positive_regulation AKT3 ANGPT1 22454630 832665 Positive_regulation AKT3 ANGPT1 22611498 1145660 Positive_regulation AKT3 ANGPT1 22792187 2661145 Positive_regulation AKT3 ANGPT1 23554782 1226214 Positive_regulation AKT3 ANGPT1 23653322 780696 Positive_regulation AKT3 ANGPT1 24013716 2842134 Positive_regulation AKT3 ANGPT1 24459518 746246 Positive_regulation AKT3 ANGPT1 25329960 3017084 Positive_regulation AKT3 ANGPT1 25371820 1690108 Positive_regulation AKT3 ARSA 19966835 8441 Positive_regulation AKT3 AXIN2 20578217 1237706 Positive_regulation AKT3 BPI 17060474 1543059 Positive_regulation AKT3 C1QTNF1 24827430 2969825 Positive_regulation AKT3 CAPN8 23425388 275542 Positive_regulation AKT3 CAPN8 23425388 275543 Positive_regulation AKT3 CAPN8 23425388 275734 Positive_regulation AKT3 CCND1 20049173 1671594 Positive_regulation AKT3 CCND1 21297902 496670 Positive_regulation AKT3 CCND1 22799881 265312 Positive_regulation AKT3 CCND1 24348821 2167423 Positive_regulation AKT3 CCND1 25047753 240865 Positive_regulation AKT3 CEACAM6 25398131 3027584 Positive_regulation AKT3 CHI3L1 19414556 1554753 Positive_regulation AKT3 CHI3L1 20224674 35541 Positive_regulation AKT3 CHI3L1 23840582 2815325 Positive_regulation AKT3 CHI3L1 23972995 608985 Positive_regulation AKT3 CHI3L1 23972995 608986 Positive_regulation AKT3 CHI3L1 23972995 609014 Positive_regulation AKT3 CHI3L1 24281168 501791 Positive_regulation AKT3 CLU 24156019 492158 Positive_regulation AKT3 CTGF 19152120 1478380 Positive_regulation AKT3 CTGF 22491319 1933897 Positive_regulation AKT3 CTGF 23208610 1478673 Positive_regulation AKT3 CTGF 23208610 1478676 Positive_regulation AKT3 CTGF 23208610 1478679 Positive_regulation AKT3 CTGF 23755163 2801569 Positive_regulation AKT3 CTGF 25478966 3032187 Positive_regulation AKT3 DAPK1 24710474 618148 Positive_regulation AKT3 EDN2 24523730 3077095 Positive_regulation AKT3 EFNB1 22879882 2672855 Positive_regulation AKT3 EFNB1 23764850 562400 Positive_regulation AKT3 EPHB2 17915029 384375 Positive_regulation AKT3 EPHB2 18004277 1902408 Positive_regulation AKT3 EPHB2 18091994 2381399 Positive_regulation AKT3 EPHB2 18091994 2381405 Positive_regulation AKT3 EPHB2 18430238 247559 Positive_regulation AKT3 EPHB2 18852899 2397605 Positive_regulation AKT3 EPHB2 19039330 545815 Positive_regulation AKT3 EPHB2 20520761 2451883 Positive_regulation AKT3 EPHB2 20532039 2452220 Positive_regulation AKT3 EPHB2 20625388 2454933 Positive_regulation AKT3 EPHB2 20661223 2133169 Positive_regulation AKT3 EPHB2 21048967 2480317 Positive_regulation AKT3 EPHB2 21048967 2480325 Positive_regulation AKT3 EPHB2 21048967 2480332 Positive_regulation AKT3 EPHB2 22116303 438048 Positive_regulation AKT3 EPHB2 22159814 1140727 Positive_regulation AKT3 EPHB2 22558291 2625019 Positive_regulation AKT3 EPHB2 22649371 874959 Positive_regulation AKT3 EPHB2 22654833 876151 Positive_regulation AKT3 EPHB2 23213390 168041 Positive_regulation AKT3 EPHB2 23345981 3177040 Positive_regulation AKT3 EPHB2 23420122 2163414 Positive_regulation AKT3 EPHB2 23554919 2773908 Positive_regulation AKT3 EPHB2 23591770 3135523 Positive_regulation AKT3 EPHB2 23755222 2802116 Positive_regulation AKT3 EPHB2 23762063 1069285 Positive_regulation AKT3 EPHB2 24018888 1112437 Positive_regulation AKT3 EPHB2 24031151 3230687 Positive_regulation AKT3 EPHB2 24116164 2865625 Positive_regulation AKT3 EPHB2 24131623 270103 Positive_regulation AKT3 EPHB2 24155779 1240239 Positive_regulation AKT3 EPHB2 24168056 1700817 Positive_regulation AKT3 EPHB2 24321545 410815 Positive_regulation AKT3 EPHB2 24498405 2919623 Positive_regulation AKT3 EPHB2 24533454 271673 Positive_regulation AKT3 EPHB2 24721622 1679091 Positive_regulation AKT3 EPHB2 24739440 1679367 Positive_regulation AKT3 EPHB2 24744103 495049 Positive_regulation AKT3 EPHB2 24797725 2189714 Positive_regulation AKT3 EPHB2 24859236 2974821 Positive_regulation AKT3 EPHB2 24978597 2985594 Positive_regulation AKT3 EPHB2 25019090 1496525 Positive_regulation AKT3 EPHB2 25019090 1496526 Positive_regulation AKT3 EPHB2 25295009 966023 Positive_regulation AKT3 F2R 23236426 2726349 Positive_regulation AKT3 F2R 23239877 1205874 Positive_regulation AKT3 F2R 24385683 1756408 Positive_regulation AKT3 FAS 11121444 1265872 Positive_regulation AKT3 FAS 22824368 1724877 Positive_regulation AKT3 FHL1 24952875 274084 Positive_regulation AKT3 FOXO1 17997602 3040244 Positive_regulation AKT3 FOXO1 19108710 324550 Positive_regulation AKT3 FOXO1 20007934 712137 Positive_regulation AKT3 FOXO1 20139898 8982 Positive_regulation AKT3 FOXO1 20375467 26937 Positive_regulation AKT3 FOXO1 21295499 1040430 Positive_regulation AKT3 FOXO1 21335550 1190774 Positive_regulation AKT3 FOXO1 22312004 1395046 Positive_regulation AKT3 FOXO1 22649777 939934 Positive_regulation AKT3 FOXO1 23268536 740203 Positive_regulation AKT3 FOXO1 24015318 2842822 Positive_regulation AKT3 FOXO1 24490110 3151529 Positive_regulation AKT3 FOXO1 25271153 1211024 Positive_regulation AKT3 FUT4 23887626 564156 Positive_regulation AKT3 FUT4 23887626 564166 Positive_regulation AKT3 GAB3 16009726 1321437 Positive_regulation AKT3 GAB3 23805312 2808425 Positive_regulation AKT3 GLP1R 24843641 1494462 Positive_regulation AKT3 HBEGF 19470173 1503698 Positive_regulation AKT3 HBEGF 19935697 2128262 Positive_regulation AKT3 HBEGF 22496644 3056075 Positive_regulation AKT3 HBEGF 22873932 533020 Positive_regulation AKT3 HBEGF 24136232 568209 Positive_regulation AKT3 HES2 22004682 1863789 Positive_regulation AKT3 HES2 22004682 1863842 Positive_regulation AKT3 ID1 22139302 1879326 Positive_regulation AKT3 ID1 22139302 1879359 Positive_regulation AKT3 ID1 22139302 1879383 Positive_regulation AKT3 ID1 22139302 1879390 Positive_regulation AKT3 ID1 24970809 2193993 Positive_regulation AKT3 IFI27 21841827 2141887 Positive_regulation AKT3 IFI27 21841827 2141888 Positive_regulation AKT3 IFI27 23383273 2749919 Positive_regulation AKT3 INPP4B 21487159 2175789 Positive_regulation AKT3 INPP4B 22895072 478782 Positive_regulation AKT3 INPP4B 22895072 478797 Positive_regulation AKT3 INPP4B 24500884 492410 Positive_regulation AKT3 INPP4B 25126743 2997995 Positive_regulation AKT3 INPP4B 25542038 3036106 Positive_regulation AKT3 LAMB3 22673183 471579 Positive_regulation AKT3 LBP 25045414 2229624 Positive_regulation AKT3 MAP2K6 12838322 422775 Positive_regulation AKT3 MAP2K6 14577832 3095203 Positive_regulation AKT3 MAP2K6 18159242 2381569 Positive_regulation AKT3 MAP2K6 19917087 1676327 Positive_regulation AKT3 MAP2K6 20634980 2455764 Positive_regulation AKT3 MAP2K6 22854065 625091 Positive_regulation AKT3 MAP2K6 23112573 1915241 Positive_regulation AKT3 MAP2K6 23300886 2737079 Positive_regulation AKT3 MAP2K6 23300886 2737136 Positive_regulation AKT3 MAP2K6 24031151 3230693 Positive_regulation AKT3 MAP2K6 24036604 2184811 Positive_regulation AKT3 MAP2K6 24937142 851334 Positive_regulation AKT3 MAP2K6 24970815 2194401 Positive_regulation AKT3 MAP2K6 24978597 2985600 Positive_regulation AKT3 MMP28 22860018 2670980 Positive_regulation AKT3 MMP28 25421240 1135241 Positive_regulation AKT3 MMP7 22860018 2670995 Positive_regulation AKT3 MMP7 25421240 1135256 Positive_regulation AKT3 MUC16 23694968 3135786 Positive_regulation AKT3 NES 21682918 1862506 Positive_regulation AKT3 NGFR 21364635 549678 Positive_regulation AKT3 NGFR 22880054 2673803 Positive_regulation AKT3 NGFR 22880054 2673856 Positive_regulation AKT3 NGFR 22880054 2673857 Positive_regulation AKT3 NGFR 22880054 2673966 Positive_regulation AKT3 NNMT 23764850 562409 Positive_regulation AKT3 PECAM1 22724015 2655553 Positive_regulation AKT3 PGC 21629705 1155263 Positive_regulation AKT3 PLAT 23936774 182565 Positive_regulation AKT3 PLAT 25514242 1135684 Positive_regulation AKT3 PTGER2 19801995 8142 Positive_regulation AKT3 PTGER2 23575689 1935993 Positive_regulation AKT3 RCAN1 19124655 1553344 Positive_regulation AKT3 RGS16 25568667 987498 Positive_regulation AKT3 RGS2 25309327 871490 Positive_regulation AKT3 S1PR3 21887342 2549404 Positive_regulation AKT3 SLC28A1 23722537 562006 Positive_regulation AKT3 SLC28A1 23722537 562025 Positive_regulation AKT3 SPHK1 21625639 2525220 Positive_regulation AKT3 SPHK1 21625639 2525229 Positive_regulation AKT3 SPHK1 21625639 2525237 Positive_regulation AKT3 SPHK1 23732709 2156803 Positive_regulation AKT3 SPHK1 23732709 2156804 Positive_regulation AKT3 SPHK1 25109605 2171862 Positive_regulation AKT3 SPHK1 25109605 2171863 Positive_regulation AKT3 STK39 22402981 93095 Positive_regulation AKT3 STK39 24967401 193255 Positive_regulation AKT3 TCN1 20489726 546995 Positive_regulation AKT3 TCN1 20489726 547017 Positive_regulation AKT3 TCN1 20489726 547042 Positive_regulation AKT3 TGM2 22225906 469617 Positive_regulation AKT3 TLR7 15280422 1533147 Positive_regulation AKT3 TLR7 18227218 1548889 Positive_regulation AKT3 TLR7 22145029 2577316 Positive_regulation AKT3 TLR7 23166614 2718104 Positive_regulation AKT3 TLR7 24367261 3065425 Positive_regulation AKT3 TLR7 24740015 2953778 Positive_regulation AKT3 TLR7 24740015 2953779 Positive_regulation AKT3 TLR7 24740015 2954070 Positive_regulation AKT3 TM4SF19 25344917 2206186 Positive_regulation AKT3 TNF 11238593 1519020 Positive_regulation AKT3 TNF 15841081 425865 Positive_regulation AKT3 TNF 16872509 3107515 Positive_regulation AKT3 TNF 18443205 705808 Positive_regulation AKT3 TNF 19118493 651010 Positive_regulation AKT3 TNF 20482767 118974 Positive_regulation AKT3 TNF 20482767 118982 Positive_regulation AKT3 TNF 20836895 1657159 Positive_regulation AKT3 TNF 20836895 1657162 Positive_regulation AKT3 TNF 21386087 718496 Positive_regulation AKT3 TNF 21867555 1659540 Positive_regulation AKT3 TNF 21867555 1659560 Positive_regulation AKT3 TNF 21867555 1659603 Positive_regulation AKT3 TNF 22039465 2565525 Positive_regulation AKT3 TNF 22039465 2565541 Positive_regulation AKT3 TNF 22243518 1898895 Positive_regulation AKT3 TNF 22426696 14565 Positive_regulation AKT3 TNF 22426696 14568 Positive_regulation AKT3 TNF 22545132 2623896 Positive_regulation AKT3 TNF 22739986 556370 Positive_regulation AKT3 TNF 22837815 3131086 Positive_regulation AKT3 TNF 23028409 2219956 Positive_regulation AKT3 TNF 23071583 2702983 Positive_regulation AKT3 TNF 23071583 2702984 Positive_regulation AKT3 TNF 23071583 2702985 Positive_regulation AKT3 TNF 23071583 2702986 Positive_regulation AKT3 TNF 23071583 2702987 Positive_regulation AKT3 TNF 23071583 2703025 Positive_regulation AKT3 TNF 23071583 2703050 Positive_regulation AKT3 TNF 23071583 2703051 Positive_regulation AKT3 TNF 23071583 2703087 Positive_regulation AKT3 TNF 23071583 2703131 Positive_regulation AKT3 TNF 23071583 2703132 Positive_regulation AKT3 TNF 23071583 2703133 Positive_regulation AKT3 TNF 23071583 2703138 Positive_regulation AKT3 TNF 23071583 2703158 Positive_regulation AKT3 TNF 23150750 2225207 Positive_regulation AKT3 TNF 23293468 3179689 Positive_regulation AKT3 TNF 23437347 2756509 Positive_regulation AKT3 TNF 23437347 2756515 Positive_regulation AKT3 TNF 23437404 2756834 Positive_regulation AKT3 TNF 23437404 2756908 Positive_regulation AKT3 TNF 23437404 2756915 Positive_regulation AKT3 TNF 23789107 169892 Positive_regulation AKT3 TNF 24013271 2842021 Positive_regulation AKT3 TNF 24312381 2889126 Positive_regulation AKT3 TNF 24489443 1757400 Positive_regulation AKT3 TNF 24577082 572426 Positive_regulation AKT3 TNF 24586980 2928524 Positive_regulation AKT3 TNF 24586980 2928647 Positive_regulation AKT3 TNF 24669186 742933 Positive_regulation AKT3 TNF 24669186 742950 Positive_regulation AKT3 TNF 24669186 742951 Positive_regulation AKT3 TNF 24669186 742963 Positive_regulation AKT3 TNF 24676340 1087232 Positive_regulation AKT3 TNF 24714064 2949906 Positive_regulation AKT3 TNF 24868497 3179296 Positive_regulation AKT3 TNF 25114952 3156802 Positive_regulation AKT3 TNF 25114952 3156807 Positive_regulation AKT3 TNF 25114952 3156826 Positive_regulation AKT3 TNF 25132732 1760497 Positive_regulation AKT3 TNF 25162582 3002884 Positive_regulation AKT3 TNF 25162582 3002905 Positive_regulation AKT3 TNF 25162582 3002930 Positive_regulation AKT3 TNF 25162582 3002938 Positive_regulation AKT3 TNF 25162582 3002945 Positive_regulation AKT3 TNF 25352752 1917445 Positive_regulation AKT3 TNF 25352752 1917476 Positive_regulation AKT3 TNF PMC3272755 99491 Positive_regulation AKT3 TNFSF10 20839416 806600 Positive_regulation AKT3 TNFSF10 25003395 505006 Positive_regulation AKT3 TNFSF10 PMC2834064 134551 Positive_regulation AKT3 TP63 19517019 2419056 Positive_regulation AKT3 TP63 19517019 2419075 Positive_regulation AKT3 WNT7A 22179044 1928155 Positive_regulation AKT3 WNT7A 24287629 1939712 Positive_regulation ALAS1 PGC 17047301 1212333 Positive_regulation ALAS1 PGC 24404437 3165679 Positive_regulation ALB TNF 17183656 2373750 Positive_regulation ALB TNF 25258680 1675221 Positive_regulation ALDH18A1 PRODH 25412179 3029051 Positive_regulation ALDH1A1 HRH1 25045085 492836 Positive_regulation ALDH1A1 HRH1 25045085 492839 Positive_regulation ALDH1A1 MUC16 24594504 2118538 Positive_regulation ALDH1A1 TLR7 19190084 1051232 Positive_regulation ALDH1A2 EPHB2 19252500 1960631 Positive_regulation ALDH1A2 EPHB2 19252500 1960646 Positive_regulation ALDH1A2 EPHB2 24788806 2959475 Positive_regulation ALDH1A2 TLR7 19190084 1051133 Positive_regulation ALDH1A2 TLR7 19190084 1051134 Positive_regulation ALDH1A2 TLR7 19190084 1051135 Positive_regulation ALDH1A2 TLR7 19252500 1960603 Positive_regulation ALDH1A2 TLR7 21738472 3052153 Positive_regulation ALDH1A2 TLR7 24788806 2959540 Positive_regulation ALDH2 GABPA 21249230 2494454 Positive_regulation ALDH2 HSP90AB1 25278902 965962 Positive_regulation ALDH2 NFE2L2 21249230 2494451 Positive_regulation ALDH2 SIRT1 24040162 2846025 Positive_regulation ALDH2 SIRT1 24040162 2846032 Positive_regulation ALDH2 SIRT3 22622703 142872 Positive_regulation ALDH2 SIRT3 24265619 962938 Positive_regulation ALDH2 TNF 18433489 361483 Positive_regulation ALK EPHB2 24715763 2249897 Positive_regulation ALMS1 NES 15251038 277802 Positive_regulation ALOX5 ABL1 19503090 1948712 Positive_regulation ALOX5 ABL1 19503090 1948720 Positive_regulation ALOX5 ABL1 19503090 1948721 Positive_regulation ALOX5 ABL1 19503090 1948726 Positive_regulation ALOX5 AFF1 25402609 2160677 Positive_regulation ALOX5 AFF1 25402609 2160717 Positive_regulation ALOX5 AFF1 25402609 2160737 Positive_regulation ALOX5 AFF1 25402609 2160742 Positive_regulation ALOX5 AKT1 25302946 3014697 Positive_regulation ALOX5 ALOX5 24475136 2914870 Positive_regulation ALOX5 ALOX5AP 1469057 1302681 Positive_regulation ALOX5 ALOX5AP 1469057 1302682 Positive_regulation ALOX5 ALOX5AP 1469057 1302683 Positive_regulation ALOX5 ALOX5AP 1469057 1302684 Positive_regulation ALOX5 ALOX5AP 1469057 1302690 Positive_regulation ALOX5 ALOX5AP 17692124 3083314 Positive_regulation ALOX5 ALOX5AP 18180307 1548192 Positive_regulation ALOX5 ALOX5AP 23874790 2822886 Positive_regulation ALOX5 ALOX5AP 24906007 2977461 Positive_regulation ALOX5 ALOX5AP 8245774 1594721 Positive_regulation ALOX5 ALOX5AP 8245774 1594725 Positive_regulation ALOX5 BCR 19503090 1948711 Positive_regulation ALOX5 BCR 19503090 1948716 Positive_regulation ALOX5 BCR 19503090 1948717 Positive_regulation ALOX5 BCR 19503090 1948723 Positive_regulation ALOX5 BLK 22797726 1951251 Positive_regulation ALOX5 CA2 2154526 1563678 Positive_regulation ALOX5 CA2 23146124 409288 Positive_regulation ALOX5 CA2 24971371 1621822 Positive_regulation ALOX5 CA2 25452755 921335 Positive_regulation ALOX5 CCNA2 22363611 2601198 Positive_regulation ALOX5 CD79A 19503090 1948718 Positive_regulation ALOX5 CD79A 19503090 1948724 Positive_regulation ALOX5 CD79B 19503090 1948719 Positive_regulation ALOX5 CD79B 19503090 1948725 Positive_regulation ALOX5 CDC73 8666909 1597086 Positive_regulation ALOX5 CSF2 16776669 641092 Positive_regulation ALOX5 CTNNBL1 2549166 1577300 Positive_regulation ALOX5 CTR9 8666909 1597087 Positive_regulation ALOX5 CYSLTR1 22259262 648101 Positive_regulation ALOX5 CYSLTR2 22259262 648102 Positive_regulation ALOX5 EDNRA 18472926 1743174 Positive_regulation ALOX5 ELL 25071589 965551 Positive_regulation ALOX5 ELL 25402609 2160724 Positive_regulation ALOX5 EPHB2 23015755 1807745 Positive_regulation ALOX5 IL1A 16859534 106342 Positive_regulation ALOX5 IL5 16776669 641087 Positive_regulation ALOX5 IL6 22277352 124681 Positive_regulation ALOX5 IL8 2549166 1577301 Positive_regulation ALOX5 KLRC1 19237603 1554195 Positive_regulation ALOX5 KMT2A 25402609 2160673 Positive_regulation ALOX5 KMT2A 25402609 2160674 Positive_regulation ALOX5 KMT2A 25402609 2160675 Positive_regulation ALOX5 KMT2A 25402609 2160676 Positive_regulation ALOX5 KMT2A 25402609 2160716 Positive_regulation ALOX5 KMT2A 25402609 2160727 Positive_regulation ALOX5 KMT2A 25402609 2160728 Positive_regulation ALOX5 KMT2A 25402609 2160729 Positive_regulation ALOX5 KMT2A 25402609 2160736 Positive_regulation ALOX5 KMT2A 25402609 2160741 Positive_regulation ALOX5 LEO1 8666909 1597090 Positive_regulation ALOX5 LTB 18475555 1744315 Positive_regulation ALOX5 LYN 22439792 651779 Positive_regulation ALOX5 MCOLN1 19065997 3208644 Positive_regulation ALOX5 MMP3 22022214 1084185 Positive_regulation ALOX5 PAF1 8666909 1597088 Positive_regulation ALOX5 PLG 21364954 2504560 Positive_regulation ALOX5 PRDX2 23093607 2081832 Positive_regulation ALOX5 PRDX2 25402609 2160678 Positive_regulation ALOX5 PRKACB 24991451 82486 Positive_regulation ALOX5 PRKACG 24991451 82487 Positive_regulation ALOX5 PRKAR1A 24991451 82488 Positive_regulation ALOX5 PRKAR1B 24991451 82489 Positive_regulation ALOX5 PRKAR2A 24991451 82490 Positive_regulation ALOX5 PRKAR2B 24991451 82491 Positive_regulation ALOX5 PTGS2 24064666 1920008 Positive_regulation ALOX5 RUNX1 24130502 2351858 Positive_regulation ALOX5 S100A12 24516701 1024305 Positive_regulation ALOX5 SMAD3 25402609 2160670 Positive_regulation ALOX5 SMAD3 25402609 2160671 Positive_regulation ALOX5 SMAD3 25402609 2160725 Positive_regulation ALOX5 SMAD4 25402609 2160672 Positive_regulation ALOX5 SMAD4 25402609 2160726 Positive_regulation ALOX5 SP1 20046412 3231732 Positive_regulation ALOX5 TCEA1 25071589 965550 Positive_regulation ALOX5 TCEA1 25402609 2160722 Positive_regulation ALOX5 TLR4 25116953 2996583 Positive_regulation ALOX5 TLR4 25116953 2996588 Positive_regulation ALOX5 TLR4 25116953 2996594 Positive_regulation ALOX5 TNF 19065997 3208647 Positive_regulation ALOX5 TRIM26 11544173 790165 Positive_regulation ALOX5 VDR 25402609 2160668 Positive_regulation ALOX5 VDR 25402609 2160669 Positive_regulation ALOX5 VDR 25402609 2160723 Positive_regulation ALOX5 WDR61 8666909 1597089 Positive_regulation ALOX5AP ALOX5 18180307 1548193 Positive_regulation ALOX5AP ALOX5 24906007 2977462 Positive_regulation ALOX5AP EPHB2 23015755 1807746 Positive_regulation ALPI EPHB2 23831571 2152762 Positive_regulation ALPI ITGB2 8104228 1594086 Positive_regulation ALPI MAP2K6 24928904 1487993 Positive_regulation ALPI PIWIL4 23093941 2338882 Positive_regulation ALPI TLR7 23603814 1962786 Positive_regulation ALPI TNF 16504042 278992 Positive_regulation ALPI TNF 25237759 2200364 Positive_regulation ALS2 CABP4 24651125 2936416 Positive_regulation ALS3 CABP4 24651125 2936421 Positive_regulation ALS5 CABP4 24651125 2936426 Positive_regulation ALS7 CABP4 24651125 2936411 Positive_regulation AMH IGFBP1 21931746 2554306 Positive_regulation AMPH CAPN8 24454278 938625 Positive_regulation ANAPC2 HBEGF 22873932 533060 Positive_regulation ANG EPHB2 19254952 1165601 Positive_regulation ANG PLAU 20805979 2471605 Positive_regulation ANG PLAU 20805979 2471611 Positive_regulation ANG PLAU 20805979 2471612 Positive_regulation ANG PLAU 20805979 2471617 Positive_regulation ANG PLAU 20805979 2471622 Positive_regulation ANG RGS2 22363752 2601793 Positive_regulation ANGPT1 ACE 16052213 426313 Positive_regulation ANGPT1 ACE 19337534 3208671 Positive_regulation ANGPT1 ACE 22518284 1079986 Positive_regulation ANGPT1 ACE 24459521 746277 Positive_regulation ANGPT1 ACE2 24384547 694670 Positive_regulation ANGPT1 ACE2 24459521 746276 Positive_regulation ANGPT1 AKT1 19771215 1685950 Positive_regulation ANGPT1 AKT1 22448202 3190569 Positive_regulation ANGPT1 AKT1 24106271 1208378 Positive_regulation ANGPT1 AKT1 25371820 1690110 Positive_regulation ANGPT1 AKT2 19771215 1685951 Positive_regulation ANGPT1 AKT2 22448202 3190570 Positive_regulation ANGPT1 AKT2 24106271 1208379 Positive_regulation ANGPT1 AKT2 25371820 1690111 Positive_regulation ANGPT1 AKT3 19771215 1685952 Positive_regulation ANGPT1 AKT3 22448202 3190571 Positive_regulation ANGPT1 AKT3 24106271 1208380 Positive_regulation ANGPT1 AKT3 25371820 1690112 Positive_regulation ANGPT1 ANGPT1 22190963 3172958 Positive_regulation ANGPT1 ANGPT2 17341311 279558 Positive_regulation ANGPT1 ANGPT2 19025590 659092 Positive_regulation ANGPT1 ANGPT2 20687922 855076 Positive_regulation ANGPT1 ANGPT2 22086358 2009032 Positive_regulation ANGPT1 ANGPT2 22086358 2009040 Positive_regulation ANGPT1 ANGPT2 22110737 2573109 Positive_regulation ANGPT1 ANGPT2 22550599 1153418 Positive_regulation ANGPT1 ANGPT2 22911790 2676632 Positive_regulation ANGPT1 ANGPT2 23532762 452326 Positive_regulation ANGPT1 ANGPT2 23613948 2782832 Positive_regulation ANGPT1 ANGPT2 23616286 780648 Positive_regulation ANGPT1 ANGPT2 24270910 453558 Positive_regulation ANGPT1 ANGPT2 24616654 3156159 Positive_regulation ANGPT1 ANGPT2 24959006 1759694 Positive_regulation ANGPT1 APLN 22558265 2624908 Positive_regulation ANGPT1 ARG1 23840386 2812678 Positive_regulation ANGPT1 ARG2 23840386 2812679 Positive_regulation ANGPT1 ARHGAP35 21858121 2546407 Positive_regulation ANGPT1 BMPR1A 22539968 2622656 Positive_regulation ANGPT1 COMP 22412941 2609864 Positive_regulation ANGPT1 CRK 24308939 1158468 Positive_regulation ANGPT1 CTSG 25249981 965953 Positive_regulation ANGPT1 CXCL12 22558265 2624899 Positive_regulation ANGPT1 CXCR4 22558265 2624900 Positive_regulation ANGPT1 DKK3 23765731 3080570 Positive_regulation ANGPT1 DLL4 23161900 91130 Positive_regulation ANGPT1 DUSP1 24308939 1158471 Positive_regulation ANGPT1 DUSP1 24308939 1158472 Positive_regulation ANGPT1 DUSP1 24308939 1158629 Positive_regulation ANGPT1 DUSP1 24308939 1158713 Positive_regulation ANGPT1 DUSP1 24308939 1158929 Positive_regulation ANGPT1 DUSP1 24308939 1158998 Positive_regulation ANGPT1 DUSP10 24308939 1158473 Positive_regulation ANGPT1 DUSP10 24308939 1158630 Positive_regulation ANGPT1 DUSP11 24308939 1158474 Positive_regulation ANGPT1 DUSP11 24308939 1158631 Positive_regulation ANGPT1 DUSP12 24308939 1158475 Positive_regulation ANGPT1 DUSP12 24308939 1158632 Positive_regulation ANGPT1 DUSP13 24308939 1158465 Positive_regulation ANGPT1 DUSP13 24308939 1158624 Positive_regulation ANGPT1 DUSP14 24308939 1158461 Positive_regulation ANGPT1 DUSP14 24308939 1158620 Positive_regulation ANGPT1 DUSP15 24308939 1158460 Positive_regulation ANGPT1 DUSP15 24308939 1158619 Positive_regulation ANGPT1 DUSP16 24308939 1158462 Positive_regulation ANGPT1 DUSP16 24308939 1158621 Positive_regulation ANGPT1 DUSP18 24308939 1158463 Positive_regulation ANGPT1 DUSP18 24308939 1158622 Positive_regulation ANGPT1 DUSP19 24308939 1158464 Positive_regulation ANGPT1 DUSP19 24308939 1158623 Positive_regulation ANGPT1 DUSP2 24308939 1158476 Positive_regulation ANGPT1 DUSP2 24308939 1158633 Positive_regulation ANGPT1 DUSP21 24308939 1158466 Positive_regulation ANGPT1 DUSP21 24308939 1158625 Positive_regulation ANGPT1 DUSP22 24308939 1158459 Positive_regulation ANGPT1 DUSP22 24308939 1158618 Positive_regulation ANGPT1 DUSP23 24308939 1158467 Positive_regulation ANGPT1 DUSP23 24308939 1158626 Positive_regulation ANGPT1 DUSP26 24308939 1158470 Positive_regulation ANGPT1 DUSP26 24308939 1158628 Positive_regulation ANGPT1 DUSP27 24308939 1158469 Positive_regulation ANGPT1 DUSP27 24308939 1158627 Positive_regulation ANGPT1 DUSP28 24308939 1158486 Positive_regulation ANGPT1 DUSP28 24308939 1158641 Positive_regulation ANGPT1 DUSP3 24308939 1158477 Positive_regulation ANGPT1 DUSP3 24308939 1158634 Positive_regulation ANGPT1 DUSP4 24308939 1158478 Positive_regulation ANGPT1 DUSP4 24308939 1158479 Positive_regulation ANGPT1 DUSP4 24308939 1158635 Positive_regulation ANGPT1 DUSP4 24308939 1158714 Positive_regulation ANGPT1 DUSP4 24308939 1158835 Positive_regulation ANGPT1 DUSP4 24308939 1158930 Positive_regulation ANGPT1 DUSP4 24308939 1158995 Positive_regulation ANGPT1 DUSP5 24308939 1158480 Positive_regulation ANGPT1 DUSP5 24308939 1158481 Positive_regulation ANGPT1 DUSP5 24308939 1158636 Positive_regulation ANGPT1 DUSP5 24308939 1158931 Positive_regulation ANGPT1 DUSP5 24308939 1158932 Positive_regulation ANGPT1 DUSP5 24308939 1158933 Positive_regulation ANGPT1 DUSP5 24308939 1158999 Positive_regulation ANGPT1 DUSP6 24308939 1158482 Positive_regulation ANGPT1 DUSP6 24308939 1158637 Positive_regulation ANGPT1 DUSP7 24308939 1158483 Positive_regulation ANGPT1 DUSP7 24308939 1158638 Positive_regulation ANGPT1 DUSP8 24308939 1158484 Positive_regulation ANGPT1 DUSP8 24308939 1158639 Positive_regulation ANGPT1 DUSP9 24308939 1158485 Positive_regulation ANGPT1 DUSP9 24308939 1158640 Positive_regulation ANGPT1 EFNB2 19071062 691834 Positive_regulation ANGPT1 EGR1 24308939 1158836 Positive_regulation ANGPT1 EPHB4 19071062 691835 Positive_regulation ANGPT1 FOXO1 20805979 2471632 Positive_regulation ANGPT1 FRZB 22325146 1865145 Positive_regulation ANGPT1 GDF15 23431498 1082754 Positive_regulation ANGPT1 GDF15 24433482 1667544 Positive_regulation ANGPT1 GLRX 22523530 2620025 Positive_regulation ANGPT1 GLRX 22523530 2620027 Positive_regulation ANGPT1 ID1 24516656 2921362 Positive_regulation ANGPT1 IL6 19737862 1556181 Positive_regulation ANGPT1 IL8 18320019 1212560 Positive_regulation ANGPT1 JUN 24308939 1158642 Positive_regulation ANGPT1 KLKB1 25249981 965954 Positive_regulation ANGPT1 MAPK3 21795402 1793236 Positive_regulation ANGPT1 MAPK3 21795402 1793241 Positive_regulation ANGPT1 MAPK3 22792187 2661148 Positive_regulation ANGPT1 MAPK3 24308939 1158487 Positive_regulation ANGPT1 MAPK3 24308939 1158934 Positive_regulation ANGPT1 MRXS5 12956885 3095076 Positive_regulation ANGPT1 MTOR 23919981 2184009 Positive_regulation ANGPT1 NEFL 22412941 2609862 Positive_regulation ANGPT1 NOS3 21270241 717361 Positive_regulation ANGPT1 NOS3 21270241 717362 Positive_regulation ANGPT1 NOS3 25371820 1690113 Positive_regulation ANGPT1 NOTCH1 23161900 91131 Positive_regulation ANGPT1 NOTCH1 23161900 91191 Positive_regulation ANGPT1 NOTCH2 23161900 91132 Positive_regulation ANGPT1 NOTCH3 22558265 2624909 Positive_regulation ANGPT1 NOTCH3 23161900 91133 Positive_regulation ANGPT1 NOTCH4 23161900 91134 Positive_regulation ANGPT1 NOTCH4 23161900 91192 Positive_regulation ANGPT1 PAH 19737862 1556176 Positive_regulation ANGPT1 PDGFRB 22087289 2571289 Positive_regulation ANGPT1 PDGFRB 23742074 1699972 Positive_regulation ANGPT1 PI3 19771215 1685953 Positive_regulation ANGPT1 PIK3CA 22448202 3190572 Positive_regulation ANGPT1 PIK3CA 23919981 2184010 Positive_regulation ANGPT1 PIK3CA 25371820 1690114 Positive_regulation ANGPT1 PIK3R1 22448202 3190573 Positive_regulation ANGPT1 PIK3R1 23919981 2184011 Positive_regulation ANGPT1 PIK3R1 25371820 1690115 Positive_regulation ANGPT1 PLAT 22432023 2611612 Positive_regulation ANGPT1 PLAU 20805979 2471625 Positive_regulation ANGPT1 PLAUR 20805979 2471626 Positive_regulation ANGPT1 POSTN 25369801 1887272 Positive_regulation ANGPT1 POSTN 25369801 1887278 Positive_regulation ANGPT1 PTPN6 22454630 832625 Positive_regulation ANGPT1 PTPRS 23213447 168837 Positive_regulation ANGPT1 RAC1 16157706 1324016 Positive_regulation ANGPT1 RASA1 24013716 2842137 Positive_regulation ANGPT1 REG1A 22454630 832626 Positive_regulation ANGPT1 REN 17583183 3208437 Positive_regulation ANGPT1 REN 21949629 1146578 Positive_regulation ANGPT1 REN 23756824 1735760 Positive_regulation ANGPT1 REN 24459521 746294 Positive_regulation ANGPT1 REN 25249981 965955 Positive_regulation ANGPT1 RHOA 25371820 1690103 Positive_regulation ANGPT1 SELP 25371820 1690124 Positive_regulation ANGPT1 SHH 20098680 2437848 Positive_regulation ANGPT1 SHH 20687922 855072 Positive_regulation ANGPT1 SHH 22432023 2611592 Positive_regulation ANGPT1 SHH 22432023 2611593 Positive_regulation ANGPT1 SHH 22432023 2611611 Positive_regulation ANGPT1 SHH 22432023 2611614 Positive_regulation ANGPT1 SHH 23894369 2824407 Positive_regulation ANGPT1 SHH 23894369 2824408 Positive_regulation ANGPT1 SHH 23894369 2824417 Positive_regulation ANGPT1 SHH 23894369 2824418 Positive_regulation ANGPT1 SHH 23894369 2824419 Positive_regulation ANGPT1 SHH 23894369 2824420 Positive_regulation ANGPT1 SHH 23894369 2824426 Positive_regulation ANGPT1 STAT5A 22792187 2661147 Positive_regulation ANGPT1 TAC1 24998254 19164 Positive_regulation ANGPT1 TAC1 24998254 19219 Positive_regulation ANGPT1 TAC3 24998254 19165 Positive_regulation ANGPT1 TAC3 24998254 19220 Positive_regulation ANGPT1 TAC4 24998254 19166 Positive_regulation ANGPT1 TAC4 24998254 19221 Positive_regulation ANGPT1 TEK 22190963 3172957 Positive_regulation ANGPT1 TET1 23554691 1226009 Positive_regulation ANGPT1 TET2 23554691 1226007 Positive_regulation ANGPT1 TET3 23554691 1226008 Positive_regulation ANGPT1 TIE1 11342585 1519393 Positive_regulation ANGPT1 TIE1 17341311 279551 Positive_regulation ANGPT1 TIE1 17341311 279557 Positive_regulation ANGPT1 TIE1 18835934 707034 Positive_regulation ANGPT1 TIE1 19451274 1366057 Positive_regulation ANGPT1 TIE1 19451274 1366058 Positive_regulation ANGPT1 TIE1 19451274 1366074 Positive_regulation ANGPT1 TIE1 19451274 1366075 Positive_regulation ANGPT1 TIE1 19821965 254314 Positive_regulation ANGPT1 TIE1 19922791 613174 Positive_regulation ANGPT1 TIE1 19922791 613175 Positive_regulation ANGPT1 TIE1 19922791 613199 Positive_regulation ANGPT1 TIE1 20414333 1672051 Positive_regulation ANGPT1 TIE1 20805979 2471631 Positive_regulation ANGPT1 TIE1 21270241 717370 Positive_regulation ANGPT1 TIE1 21378411 2175497 Positive_regulation ANGPT1 TIE1 21439064 1504937 Positive_regulation ANGPT1 TIE1 21779348 2536806 Positive_regulation ANGPT1 TIE1 22187650 1145424 Positive_regulation ANGPT1 TIE1 22343031 1651749 Positive_regulation ANGPT1 TIE1 22454630 832624 Positive_regulation ANGPT1 TIE1 23131162 653807 Positive_regulation ANGPT1 TIE1 24013716 2842136 Positive_regulation ANGPT1 TIE1 24145226 545109 Positive_regulation ANGPT1 TIE1 24308939 1158834 Positive_regulation ANGPT1 TIE1 24347761 1047893 Positive_regulation ANGPT1 TIE1 24606812 272268 Positive_regulation ANGPT1 TIE1 25371820 1690136 Positive_regulation ANGPT1 TNF 15642148 102422 Positive_regulation ANGPT1 VDR 24084056 2118313 Positive_regulation ANGPT1 VEGFA 18947376 111698 Positive_regulation ANGPT1 VEGFA 19435476 659194 Positive_regulation ANGPT1 VEGFA 25162491 3002618 Positive_regulation ANGPT1 WT1 24810959 2190125 Positive_regulation ANGPT2 ANGPT1 17341311 279560 Positive_regulation ANGPT2 ANGPT1 19025590 659093 Positive_regulation ANGPT2 ANGPT1 19435476 659221 Positive_regulation ANGPT2 ANGPT1 19863762 1163713 Positive_regulation ANGPT2 ANGPT1 22086358 2009033 Positive_regulation ANGPT2 ANGPT1 22110737 2573110 Positive_regulation ANGPT2 ANGPT1 22550599 1153419 Positive_regulation ANGPT2 ANGPT1 22792187 2661214 Positive_regulation ANGPT2 ANGPT1 22911790 2676633 Positive_regulation ANGPT2 ANGPT1 23613948 2782831 Positive_regulation ANGPT2 ANGPT1 23613948 2782833 Positive_regulation ANGPT2 ANGPT1 23637753 2785734 Positive_regulation ANGPT2 ANGPT1 24270910 453559 Positive_regulation ANGPT2 ANGPT1 24753650 89041 Positive_regulation ANGPT2 ANGPT1 24760505 2251940 Positive_regulation ANGPT2 ANGPT1 24959006 1759695 Positive_regulation ANGPT2 ANGPT1 25289295 2255035 Positive_regulation ANGPT2 CAPN8 18493299 2388950 Positive_regulation ANGPT2 CCL17 24634660 964481 Positive_regulation ANGPT2 CCND1 20037604 8640 Positive_regulation ANGPT2 CCND1 20037604 8692 Positive_regulation ANGPT2 CCND1 20037604 8693 Positive_regulation ANGPT2 CLU 25148511 3002029 Positive_regulation ANGPT2 CLU 25148511 3002030 Positive_regulation ANGPT2 CLU 25148511 3002036 Positive_regulation ANGPT2 CLU 25148511 3002039 Positive_regulation ANGPT2 CTGF 21941677 1082289 Positive_regulation ANGPT2 CTGF 25132338 19420 Positive_regulation ANGPT2 EPHB2 19132133 3074842 Positive_regulation ANGPT2 EPHB2 22310788 1710686 Positive_regulation ANGPT2 EPHB2 23243430 816461 Positive_regulation ANGPT2 EPHB2 23646205 2788770 Positive_regulation ANGPT2 EPHB2 23691054 2794173 Positive_regulation ANGPT2 EPHB2 23691054 2794182 Positive_regulation ANGPT2 EPHB2 24827991 2969913 Positive_regulation ANGPT2 FOXO1 18355401 1646231 Positive_regulation ANGPT2 FOXO1 19435476 659216 Positive_regulation ANGPT2 ID1 24516656 2921360 Positive_regulation ANGPT2 MAP2K6 15134586 274360 Positive_regulation ANGPT2 MMP28 23161900 91197 Positive_regulation ANGPT2 MMP28 24811612 1159607 Positive_regulation ANGPT2 MMP7 23161900 91212 Positive_regulation ANGPT2 MMP7 24811612 1159622 Positive_regulation ANGPT2 TNF 19416526 659187 Positive_regulation ANGPT2 TNF 19435476 659203 Positive_regulation ANGPT2 TNF 22500179 1143843 Positive_regulation ANGPT2 TNF 24433482 1667538 Positive_regulation ANGPTL3 PGC 25495645 216823 Positive_regulation ANGPTL4 EPHB2 23617883 1867921 Positive_regulation ANGPTL4 FAS 23056264 2700755 Positive_regulation ANGPTL4 FAS 23056264 2700756 Positive_regulation ANK1 EFNB1 24023801 2843578 Positive_regulation ANK1 EPHB2 24023801 2843582 Positive_regulation ANK2 EFNB1 24023801 2843586 Positive_regulation ANK2 EPHB2 24023801 2843590 Positive_regulation ANK3 EFNB1 24023801 2843594 Positive_regulation ANK3 EPHB2 24023801 2843598 Positive_regulation ANK3 NFASC 21382554 2010198 Positive_regulation ANK3 NFASC 9744885 1470803 Positive_regulation ANKRD1 ANGPT2 25089522 2994526 Positive_regulation ANKRD1 ANGPT2 25089522 2994527 Positive_regulation ANKRD1 IFIT2 22808421 3130954 Positive_regulation ANKRD1 IL1A 22808421 3130955 Positive_regulation ANKRD1 TNF 22808421 3130953 Positive_regulation ANKRD2 ANKRD1 22016770 2562480 Positive_regulation ANO1 BDKRB2 24277599 1610699 Positive_regulation ANO1 CA2 21642943 12810 Positive_regulation ANO1 CA2 21772822 955439 Positive_regulation ANO1 CA2 22912841 2679581 Positive_regulation ANO1 CA2 24081981 1610597 Positive_regulation ANO1 CA2 24081981 1610605 Positive_regulation ANO1 CA2 24081981 1610608 Positive_regulation ANO1 CA2 24396339 684882 Positive_regulation ANO1 CA2 24420770 1611153 Positive_regulation ANO1 CA2 24420770 1611154 Positive_regulation ANO1 CA2 24420770 1611155 Positive_regulation ANO1 CA2 24420770 1611169 Positive_regulation ANO1 CA2 24420770 1611180 Positive_regulation ANO1 CA2 24420770 1611186 Positive_regulation ANO1 CA2 24420770 1611187 Positive_regulation ANO1 CA2 24420770 1611220 Positive_regulation ANO1 CA2 24450308 1900104 Positive_regulation ANO1 CA2 24478713 963493 Positive_regulation ANO1 CA2 24478713 963494 Positive_regulation ANO1 CA2 24478713 963499 Positive_regulation ANO1 CA2 24489780 2916227 Positive_regulation ANO1 CA2 24489780 2916228 Positive_regulation ANO1 CA2 24489780 2916234 Positive_regulation ANO1 CA2 24489780 2916235 Positive_regulation ANO1 CA2 24489780 2916236 Positive_regulation ANO1 CA2 24551253 2372452 Positive_regulation ANO1 CA2 24901998 2977015 Positive_regulation ANO1 CA2 24901998 2977016 Positive_regulation ANO1 CA2 24901998 2977023 Positive_regulation ANO1 CA2 24901998 2977024 Positive_regulation ANO1 CA2 24901998 2977039 Positive_regulation ANO1 CA2 24901998 2977040 Positive_regulation ANO1 CA2 25117505 2996612 Positive_regulation ANO1 CALM3 21642943 12811 Positive_regulation ANO1 CALM3 21642943 12813 Positive_regulation ANO1 CALM3 24420770 1611156 Positive_regulation ANO1 CALM3 24420770 1611157 Positive_regulation ANO1 CALM3 24420770 1611170 Positive_regulation ANO1 CALM3 24420770 1611181 Positive_regulation ANO1 CALM3 24420770 1611188 Positive_regulation ANO1 CALM3 24420770 1611189 Positive_regulation ANO1 CALM3 24420770 1611200 Positive_regulation ANO1 CALM3 24420770 1611201 Positive_regulation ANO1 CALM3 24420770 1611221 Positive_regulation ANO1 CALM3 24901998 2977011 Positive_regulation ANO1 CALM3 24901998 2977017 Positive_regulation ANO1 CALM3 24901998 2977018 Positive_regulation ANO1 CALM3 24901998 2977025 Positive_regulation ANO1 CALM3 24901998 2977041 Positive_regulation ANO1 CALM3 24980701 759220 Positive_regulation ANO1 CALM3 24980701 759221 Positive_regulation ANO1 CALM3 24980701 759223 Positive_regulation ANO1 CD9 24420770 1611158 Positive_regulation ANO1 CD9 24489780 2916229 Positive_regulation ANO1 CFTR 24885604 359404 Positive_regulation ANO1 DSP 23676845 589630 Positive_regulation ANO1 ELL 24904627 970820 Positive_regulation ANO1 EPHA3 25117505 2996599 Positive_regulation ANO1 F2RL1 24277599 1610700 Positive_regulation ANO1 IL8 22973054 1807591 Positive_regulation ANO1 MCOLN1 24420770 1611152 Positive_regulation ANO1 MCOLN1 24489780 2916224 Positive_regulation ANO1 P2RX4 24391597 963241 Positive_regulation ANO1 PDGFB 25268501 3011491 Positive_regulation ANO1 SLC4A2 24478713 963498 Positive_regulation ANO1 TCEA1 24904627 970819 Positive_regulation ANO1 ZNF282 21423668 2322579 Positive_regulation ANP32A RNASE1 15983058 1320872 Positive_regulation ANPEP IL6R 17501984 300002 Positive_regulation ANPEP SYT8 19047463 1361908 Positive_regulation ANXA1 CAPN8 11489944 1520039 Positive_regulation ANXA1 CAPN8 19399237 1088219 Positive_regulation ANXA1 CAPN8 21902831 3160669 Positive_regulation ANXA1 NES 21278733 1966565 Positive_regulation ANXA1 TNF 14568984 1529242 Positive_regulation ANXA1 TNF 21736731 1898355 Positive_regulation ANXA2 NES 23226323 2724116 Positive_regulation ANXA2 NES 23226323 2724125 Positive_regulation ANXA2 NES 23226323 2724127 Positive_regulation ANXA2 NES 23434659 1101896 Positive_regulation ANXA2 PCSK9 22848640 2669935 Positive_regulation ANXA5 FAS 15144016 702431 Positive_regulation ANXA5 TNF 24927773 3102517 Positive_regulation ANXA5 TNFSF10 19421137 2125085 Positive_regulation ANXA6 ALOX5 23613965 2782919 Positive_regulation ANXA6 CAPN8 24611062 880443 Positive_regulation ANXA6 CCND1 24970389 411244 Positive_regulation ANXA6 EPHB2 16255777 1695471 Positive_regulation ANXA6 EPHB2 22122896 1704120 Positive_regulation ANXA6 EPHB2 22537317 355857 Positive_regulation ANXA6 EPHB2 22751450 1720720 Positive_regulation ANXA6 EPHB2 23853721 1689951 Positive_regulation ANXA6 EPHB2 24312679 2890639 Positive_regulation ANXA6 HBEGF 22984591 2689369 Positive_regulation ANXA6 IL1B 21729292 405043 Positive_regulation ANXA6 MAP2K6 16255777 1695477 Positive_regulation ANXA6 NES 25133189 196810 Positive_regulation ANXA6 RAB31 24165808 809000 Positive_regulation ANXA6 TLR7 15851485 1535697 Positive_regulation ANXA6 TLR7 15851485 1535698 Positive_regulation ANXA6 TLR7 18322684 487876 Positive_regulation ANXA6 TLR7 18322684 487960 Positive_regulation ANXA6 TLR7 22513098 125425 Positive_regulation ANXA6 TLR7 22815909 2666765 Positive_regulation ANXA6 TLR7 22927956 2681208 Positive_regulation ANXA6 TLR7 23189270 863858 Positive_regulation ANXA6 TLR7 23421931 590840 Positive_regulation ANXA6 TLR7 23421931 590910 Positive_regulation ANXA6 TLR7 23755218 2801978 Positive_regulation ANXA6 TLR7 23762309 2802934 Positive_regulation ANXA6 TNF 21591259 776238 Positive_regulation ANXA6 TNF 21829352 3052662 Positive_regulation ANXA6 TNF 24312355 2888913 Positive_regulation ANXA6 TNF 24330807 1667440 Positive_regulation ANXA6 TNF 24586980 2928562 Positive_regulation ANXA6 TP63 1357073 1528537 Positive_regulation ANXA6 TP63 23221473 3217381 Positive_regulation AOC3 SELL 8627168 1596143 Positive_regulation AOC3 SELL 8627168 1596144 Positive_regulation AOC3 SELL 9254657 1601432 Positive_regulation AP1B1 EPHB2 19724275 432705 Positive_regulation AP1B1 MAP2K6 19724275 432711 Positive_regulation AP1B1 TNF 19638230 401829 Positive_regulation AP1G1 EPHB2 19724275 432713 Positive_regulation AP1G1 MAP2K6 19724275 432719 Positive_regulation AP1G1 TNF 19638230 401830 Positive_regulation AP2B1 SYT8 22808098 2664650 Positive_regulation AP2M1 SYT8 22808098 2664669 Positive_regulation AP2S1 SYT8 22808098 2664688 Positive_regulation APAF1 FAS 18769617 2396032 Positive_regulation APAF1 TP63 20429941 328899 Positive_regulation APC ALDH2 23468836 2759750 Positive_regulation APC ALDH2 23468836 2759753 Positive_regulation APC AXIN2 10330403 1246270 Positive_regulation APC AXIN2 10330403 1246272 Positive_regulation APC AXIN2 10330403 1246281 Positive_regulation APC AXIN2 22645652 2208451 Positive_regulation APC CCND1 17407548 1846312 Positive_regulation APC EPHB2 20403177 659543 Positive_regulation APC F2R 12720558 658478 Positive_regulation APC F2R 16277710 658598 Positive_regulation APC F2R 17893198 1547104 Positive_regulation APC F2R 17893198 1547110 Positive_regulation APC F2R 18269690 658917 Positive_regulation APC F2R 18269690 658921 Positive_regulation APC F2R 22518344 1082543 Positive_regulation APC F2R 23717683 2798747 Positive_regulation APC F2R 23739325 1990497 Positive_regulation APC F2R 24152910 220924 Positive_regulation APC F2R 24733067 1126062 Positive_regulation APC FAS 19667130 1367781 Positive_regulation APC IFI27 23029392 2697078 Positive_regulation APC ITGAL 19901985 2430813 Positive_regulation APC ITGAL 22474478 634215 Positive_regulation APC ITGAL 24376655 2901689 Positive_regulation APC ITGAL 2952751 1579183 Positive_regulation APC ITGB2 7525839 1589663 Positive_regulation APC KRT38 24860547 880627 Positive_regulation APC TGM2 1003103 1511106 Positive_regulation APC TGM2 1003103 1511107 Positive_regulation APC TGM2 1003103 1511108 Positive_regulation APC TGM2 1003103 1511109 Positive_regulation APC TGM2 1003103 1511110 Positive_regulation APC TGM2 1003103 1511137 Positive_regulation APC TGM2 1003103 1511144 Positive_regulation APC TLR7 19171766 1553694 Positive_regulation APC TLR7 21892173 1955829 Positive_regulation APC TLR7 22461749 3229300 Positive_regulation APC TLR7 23908972 864189 Positive_regulation APC TLR7 24676425 3066565 Positive_regulation APC TLR7 24715890 912048 Positive_regulation APC TLR7 25486609 3032871 Positive_regulation APC TNF 15458574 350575 Positive_regulation APC TNF 19229322 3043329 Positive_regulation APC TNF 22879717 88203 Positive_regulation APC WNT7A 12716446 99636 Positive_regulation APC WNT7A 18652670 1891075 Positive_regulation APCS EPHB2 22163180 1729420 Positive_regulation APCS GPR115 20584999 715386 Positive_regulation APCS GPR132 20584999 715375 Positive_regulation APCS GPR87 20584999 715455 Positive_regulation APCS ITGB2 15955836 1536441 Positive_regulation APCS ITGB2 24376655 2901737 Positive_regulation APCS TLR7 12045249 1523556 Positive_regulation APCS TLR7 20525148 34492 Positive_regulation APCS TLR7 21612602 354500 Positive_regulation APCS TLR7 21747878 1710435 Positive_regulation APCS TLR7 21747878 1710462 Positive_regulation APCS TLR7 21861904 622126 Positive_regulation APCS TLR7 23970886 908651 Positive_regulation APCS TLR7 24130558 909218 Positive_regulation APCS TLR7 25101080 913643 Positive_regulation APCS TNF 10637268 1514136 Positive_regulation APCS TNF 10637268 1514140 Positive_regulation APLN EPHB2 21437254 2509136 Positive_regulation APLN EPHB2 21437254 2509148 Positive_regulation APLN GPR115 21410966 358193 Positive_regulation APLN GPR132 21410966 358182 Positive_regulation APLN GPR87 21410966 358262 Positive_regulation APLN TNF 22007137 1749421 Positive_regulation APLN TNF 22194660 3152360 Positive_regulation APLN TNF 23476106 1751692 Positive_regulation APLN TNF 23781214 878793 Positive_regulation APLP2 PCSK9 23430252 1206571 Positive_regulation APLP2 PCSK9 23430252 1206618 Positive_regulation APOA1 CD14 23781332 627801 Positive_regulation APOA1 EPHB2 20102334 651198 Positive_regulation APOB CD14 20946675 1723281 Positive_regulation APOB EPHB2 19158958 1908801 Positive_regulation APOB EPHB2 23144813 2714616 Positive_regulation APOB EPHB2 23144813 2714618 Positive_regulation APOB EPHB2 24428917 1726707 Positive_regulation APOB FAS 24382338 1726692 Positive_regulation APOB FOXO1 19584310 710415 Positive_regulation APOB G0S2 23951308 2834126 Positive_regulation APOB PCSK9 20423497 2112638 Positive_regulation APOB PCSK9 21232153 1723403 Positive_regulation APOB PCSK9 22355267 1059718 Positive_regulation APOB PCSK9 23329883 1084341 Positive_regulation APOB PCSK9 23344623 1905757 Positive_regulation APOB PCSK9 25172365 785276 Positive_regulation APOB PECAM1 23956504 1754503 Positive_regulation APOB TNF 23499576 3204119 Positive_regulation APOB TNF 23825600 2809792 Positive_regulation APOB TNF 24968272 1127941 Positive_regulation APOBEC3G EPHB2 19371434 3117743 Positive_regulation APOBEC3G RNASE1 17291161 3039460 Positive_regulation APOBEC3G RNASE1 18577210 3116954 Positive_regulation APOBEC3G RNASE1 19497112 3117929 Positive_regulation APOBEC3G RNASE7 17291161 3039468 Positive_regulation APOBEC3G RNASE7 18577210 3116962 Positive_regulation APOBEC3G TLR7 25352838 927346 Positive_regulation APOE EPHB2 22171672 1660370 Positive_regulation APOE IL1B 21112383 833404 Positive_regulation APOE PCSK9 23883163 1726234 Positive_regulation APOE TNF 18678613 706669 Positive_regulation APOE TNF 23843680 1753849 Positive_regulation APOM FOXA1 25144649 3001133 Positive_regulation APP ALOX5 22222029 1894618 Positive_regulation APP EPHB2 22103431 651467 Positive_regulation APP S100B 19668572 649435 Positive_regulation APP S100B 23866266 1666876 Positive_regulation APP S100B 23866266 1666892 Positive_regulation APP S100B 23866266 1666903 Positive_regulation APP SORL1 16930455 1890596 Positive_regulation APP SORL1 16930455 1890643 Positive_regulation APP SORL1 17620134 1890897 Positive_regulation APP SORL1 20368139 1031097 Positive_regulation APP SORL1 20937087 1891736 Positive_regulation APP SORL1 23429712 650712 Positive_regulation APP TNF 22047170 1660165 Positive_regulation APP TNF 22047170 1660166 Positive_regulation APP TNF 22047170 1660182 Positive_regulation APP TNF 22047170 1660188 Positive_regulation APP TNF 22047170 1660197 Positive_regulation APP TNF 22047170 1660198 Positive_regulation APP TNF 22276186 2590378 Positive_regulation APP TNF 25426144 695963 Positive_regulation AQP1 TNF 24369440 1755948 Positive_regulation AQP1 TNF 24369440 1755950 Positive_regulation AQP1 TNF 25371738 845396 Positive_regulation AQP2 EPHB2 18431594 2242542 Positive_regulation AQP4 EPHB2 23805198 2807743 Positive_regulation AQP4 IL1B 24074163 82899 Positive_regulation AQP4 TNF 18510734 1655524 Positive_regulation AR ADRB2 25629002 949773 Positive_regulation AR EPHB2 21829568 2541870 Positive_regulation AR EPHB2 22046506 1686733 Positive_regulation ARC EPHB2 24045785 3137126 Positive_regulation ARC EPHB2 24045785 3137159 Positive_regulation ARC EPHB2 24045785 3137164 Positive_regulation ARC EPHB2 24045785 3137210 Positive_regulation ARCN1 TNF 23384071 3113508 Positive_regulation ARCN1 TNF 24468053 1920528 Positive_regulation ARCN1 TNNT2 23315609 1027373 Positive_regulation AREG AGR2 22333441 313510 Positive_regulation AREG AGR2 22605983 1095655 Positive_regulation AREG AGR2 23635006 473256 Positive_regulation AREG AGR2 25111734 2996332 Positive_regulation AREG EPHB2 21258428 1030569 Positive_regulation AREG MIP 18955794 1635059 Positive_regulation AREG MMP28 21489260 362952 Positive_regulation AREG MMP28 25147440 1761684 Positive_regulation AREG MMP7 21489260 362967 Positive_regulation AREG MMP7 25147440 1761699 Positive_regulation AREG PLAU 23844004 2818956 Positive_regulation AREG SPHK1 21936950 1697751 Positive_regulation AREG TNF 20161853 1043924 Positive_regulation AREG TNF 23905066 3188202 Positive_regulation ARF1 TLR7 23162766 2161567 Positive_regulation ARF3 TLR7 23162766 2161577 Positive_regulation ARF4 TLR7 23162766 2161587 Positive_regulation ARF5 TLR7 23162766 2161597 Positive_regulation ARF6 EPHB2 20462959 1776134 Positive_regulation ARF6 TLR7 23162766 2161607 Positive_regulation ARFRP1 FOXO1 17010188 232454 Positive_regulation ARG1 EPHB2 21559295 2518097 Positive_regulation ARG1 EPHB2 21559295 2518114 Positive_regulation ARG1 LBP 23517687 294307 Positive_regulation ARG1 MMP28 19405959 463809 Positive_regulation ARG1 MMP7 19405959 463824 Positive_regulation ARG1 TLR7 20029630 1213439 Positive_regulation ARG1 TLR7 21246055 2492983 Positive_regulation ARG1 TLR7 22811737 636670 Positive_regulation ARG1 TLR7 25538892 949199 Positive_regulation ARG1 TNF 19696185 710964 Positive_regulation ARG1 TNF 22069588 3182551 Positive_regulation ARG1 TNF 23577028 1674553 Positive_regulation ARG2 EPHB2 21559295 2518098 Positive_regulation ARG2 EPHB2 21559295 2518115 Positive_regulation ARG2 MMP28 19405959 463831 Positive_regulation ARG2 MMP7 19405959 463846 Positive_regulation ARG2 TLR7 21869919 1680414 Positive_regulation ARG2 TLR7 22811737 636680 Positive_regulation ARG2 TNF 19696185 710967 Positive_regulation ARG2 TNF 22069588 3182553 Positive_regulation ARG2 TNFSF10 22194670 3152401 Positive_regulation ARHGAP35 ANGPT1 21858121 2546406 Positive_regulation ARHGEF1 TNF 21473788 1658065 Positive_regulation ARHGEF1 TNF 21473788 1658067 Positive_regulation ARHGEF1 TNF 21473788 1658073 Positive_regulation ARHGEF1 TNF 21473788 1658080 Positive_regulation ARHGEF15 EPHB2 23476809 2003071 Positive_regulation ARHGEF2 EPHB2 21572419 1925883 Positive_regulation ARHGEF2 EPHB2 21572419 1925884 Positive_regulation ARHGEF2 EPHB2 23389627 1811813 Positive_regulation ARHGEF2 TNF 20089843 1773455 Positive_regulation ARHGEF2 TNF 22491204 1704534 Positive_regulation ARHGEF2 TNF 22491204 1704535 Positive_regulation ARHGEF2 TNF 23389627 1811810 Positive_regulation ARHGEF2 TNF 23389627 1811928 Positive_regulation ARHGEF2 TNF 23389627 1811947 Positive_regulation ARHGEF7 MIP 22046194 633495 Positive_regulation ARHGEF7 MIP 23226201 2723570 Positive_regulation ARHGEF7 RAB31 18974049 1164857 Positive_regulation ARID1A TNF 16177180 2017706 Positive_regulation ARID1B EPHB2 21572418 1925864 Positive_regulation ARID1B EPHB2 21860657 813123 Positive_regulation ARID4B NES 24552625 2013108 Positive_regulation ARID4B TNF 7931061 1593047 Positive_regulation ARNTL PGC 23434656 1101840 Positive_regulation ARNTL PGC 23990898 2840352 Positive_regulation ARNTL PGC 23990898 2840353 Positive_regulation ARNTL PGC 23990898 2840355 Positive_regulation ARNTL PGC 24086613 2855022 Positive_regulation ARNTL PGC 24737872 786918 Positive_regulation ARNTL RORC 18454201 2305313 Positive_regulation ARNTL RORC 18454201 2305316 Positive_regulation ARNTL TNF 24901009 1621709 Positive_regulation ARPC1B EPHB2 22876286 2672632 Positive_regulation ARPC2 EPHB2 22876286 2672633 Positive_regulation ARPC3 EPHB2 22876286 2672634 Positive_regulation ARPC4 EPHB2 22876286 2672635 Positive_regulation ARPC5 EPHB2 22876286 2672636 Positive_regulation ARSA ARSD 23808632 622594 Positive_regulation ARSA CASP10 25061812 2992434 Positive_regulation ARSA EDC3 PMC2268108 1613131 Positive_regulation ARSA EDC4 PMC2268108 1613130 Positive_regulation ARSA GABBR2 22761875 2659000 Positive_regulation ARSA GAL 21151561 2485095 Positive_regulation ARSA HSPA2 23209833 2723349 Positive_regulation ARSA MAPK1 20339548 2444472 Positive_regulation ARSA MAPK10 20339548 2444473 Positive_regulation ARSA MAPK11 20339548 2444474 Positive_regulation ARSA MAPK12 20339548 2444475 Positive_regulation ARSA MAPK13 20339548 2444476 Positive_regulation ARSA MAPK14 20339548 2444477 Positive_regulation ARSA MAPK15 20339548 2444471 Positive_regulation ARSA MAPK3 20339548 2444478 Positive_regulation ARSA MAPK3 22761875 2659001 Positive_regulation ARSA MAPK3 22761875 2659026 Positive_regulation ARSA MAPK3 22761875 2659034 Positive_regulation ARSA MAPK3 22761875 2659043 Positive_regulation ARSA MAPK3 22761875 2659047 Positive_regulation ARSA MAPK4 20339548 2444479 Positive_regulation ARSA MAPK6 20339548 2444480 Positive_regulation ARSA MAPK7 20339548 2444481 Positive_regulation ARSA MAPK8 20339548 2444482 Positive_regulation ARSA MAPK9 20339548 2444483 Positive_regulation ARSA MGAT3 24184502 154232 Positive_regulation ARSA NA 25075522 2993133 Positive_regulation ARSA NOS3 25045211 1760205 Positive_regulation ARSA PTPN6 23390550 2750898 Positive_regulation ARSA RNF19A 20339548 2444470 Positive_regulation ARSA UGCG 22510431 2113216 Positive_regulation ARSA VEGFA 21826202 2540782 Positive_regulation ARSH MUC16 11834466 790252 Positive_regulation ARSH TNF 12676602 791626 Positive_regulation ART1 FAS 25520826 1630308 Positive_regulation ART3 FAS 25520826 1630309 Positive_regulation ART4 FAS 25520826 1630310 Positive_regulation ART5 FAS 25520826 1630307 Positive_regulation ASB4 RNF150 24586788 2926706 Positive_regulation ASCL1 MMP7 23300791 2735992 Positive_regulation ASIP EMP1 16685278 427686 Positive_regulation ASIP MMP28 19405959 463904 Positive_regulation ASIP MMP7 19405959 463919 Positive_regulation ASIP TNFSF10 23754197 1141765 Positive_regulation ASS1 TNF PMC2750797 450376 Positive_regulation ATF1 EPHB2 20051107 365750 Positive_regulation ATF1 EPHB2 24132149 1113497 Positive_regulation ATF2 EPHB2 14707112 1530540 Positive_regulation ATF2 EPHB2 20581861 2132792 Positive_regulation ATF2 EPHB2 23249971 1729611 Positive_regulation ATF2 TNF 12110129 99063 Positive_regulation ATF2 TNF 21264230 2494875 Positive_regulation ATF2 TNF 22313861 3160933 Positive_regulation ATF2 TNF 23789107 169960 Positive_regulation ATF2 TNF 24069158 2851340 Positive_regulation ATF2 TNF 24069158 2851492 Positive_regulation ATF2 TNF 24069158 2851653 Positive_regulation ATF2 TNF 24707477 188444 Positive_regulation ATF2 TNF 24707477 188474 Positive_regulation ATF2 TNF 8691131 1598169 Positive_regulation ATF3 CCND1 24222778 823979 Positive_regulation ATF3 EPHB2 22053207 2568045 Positive_regulation ATF3 EPHB2 22347845 929596 Positive_regulation ATF3 EPHB2 23028726 2692706 Positive_regulation ATF3 EPHB2 25136830 2998995 Positive_regulation ATF3 EPHB2 25136830 2999037 Positive_regulation ATF3 MAP2K6 25136830 2999040 Positive_regulation ATF3 TLR7 24317040 1959568 Positive_regulation ATF3 TLR7 24317040 1959588 Positive_regulation ATF3 TNF 22053207 2568026 Positive_regulation ATF3 TNF 22614010 2147051 Positive_regulation ATF4 TNF 25470819 3032058 Positive_regulation ATF4 TNF 25470819 3032063 Positive_regulation ATF5 CREB3L2 20495567 1961047 Positive_regulation ATF5 CREB3L2 20495567 1961061 Positive_regulation ATF5 CREB3L2 20495567 1961064 Positive_regulation ATF5 CREB3L2 21711675 519098 Positive_regulation ATF6 PGC 23716639 2088894 Positive_regulation ATF6 PGC 23716639 2088895 Positive_regulation ATF6 PGC 23716639 2088896 Positive_regulation ATF6 PGC 24167585 2872232 Positive_regulation ATF6 TNF 25093191 195673 Positive_regulation ATG10 FOXO1 22281705 547773 Positive_regulation ATG10 FOXO1 24474199 3081373 Positive_regulation ATG10 FOXO1 25375380 578999 Positive_regulation ATG12 FOXO1 22281705 547776 Positive_regulation ATG12 FOXO1 24474199 3081379 Positive_regulation ATG12 FOXO1 25375380 579002 Positive_regulation ATG13 FOXO1 22281705 547775 Positive_regulation ATG13 FOXO1 24474199 3081377 Positive_regulation ATG13 FOXO1 25375380 579001 Positive_regulation ATG14 FOXO1 22281705 547772 Positive_regulation ATG14 FOXO1 24474199 3081371 Positive_regulation ATG14 FOXO1 25375380 578998 Positive_regulation ATG3 CLU 25503391 1947692 Positive_regulation ATG3 CLU 25503391 1947693 Positive_regulation ATG3 CLU 25503391 1947707 Positive_regulation ATG3 FOXO1 22281705 547774 Positive_regulation ATG3 FOXO1 24474199 3081375 Positive_regulation ATG3 FOXO1 25375380 579000 Positive_regulation ATG4D CAPN8 24350057 946762 Positive_regulation ATG5 CAPN8 19572056 2220330 Positive_regulation ATG5 CAPN8 22770472 532828 Positive_regulation ATG5 CAPN8 23437349 2756526 Positive_regulation ATG5 CAPN8 23603984 17570 Positive_regulation ATG5 FOXO1 22281705 547777 Positive_regulation ATG5 FOXO1 24474199 3081381 Positive_regulation ATG5 FOXO1 25375380 579003 Positive_regulation ATG7 FOXO1 22281705 547771 Positive_regulation ATG7 FOXO1 24474199 3081369 Positive_regulation ATG7 FOXO1 25061009 3203869 Positive_regulation ATG7 FOXO1 25375380 578997 Positive_regulation ATM CCND1 23776433 2804268 Positive_regulation ATM CCND1 23776433 2804269 Positive_regulation ATM RAB31 21958360 1767702 Positive_regulation ATM TNF 20200974 1237361 Positive_regulation ATOH8 TF 24236640 450682 Positive_regulation ATOH8 TF 24236640 450703 Positive_regulation ATP2A2 CAPN8 24489676 2915806 Positive_regulation ATP2A2 EPHB2 22751695 723535 Positive_regulation ATP5B PGC 23093952 3076068 Positive_regulation ATP5J TNF 23555853 2775543 Positive_regulation ATP5O CLU 23986700 858674 Positive_regulation ATP5O EPHB2 21286276 667777 Positive_regulation ATP5O EPHB2 21286276 667778 Positive_regulation ATP5O IL1B 16571116 1624883 Positive_regulation ATP5O PKP1 20156963 1371300 Positive_regulation ATP5O PKP1 20156963 1371309 Positive_regulation ATP5O TMOD1 24367593 2900253 Positive_regulation ATP6V0D1 CAPN8 23241453 3188436 Positive_regulation ATP7A TLR7 22610140 1957337 Positive_regulation ATP7B FOXO1 22312004 1395097 Positive_regulation ATP8A2 RNASE1 21559015 436797 Positive_regulation ATP8A2 RNASE7 21559015 436805 Positive_regulation ATP8A2 TNF 12966434 423287 Positive_regulation ATP8A2 TNF 22477519 1238966 Positive_regulation ATP8A2 TNF 24941071 2980781 Positive_regulation ATP8A2 TNF 9184176 446250 Positive_regulation ATR EPHB2 22087839 681989 Positive_regulation ATR EPHB2 22087839 681992 Positive_regulation ATR TFPI2 20860841 526881 Positive_regulation ATRAID IFI27 22566872 899105 Positive_regulation ATRAID IFI27 23509459 1073477 Positive_regulation AURKA MAP2K6 25074438 1702347 Positive_regulation AURKA MAP2K6 25074438 1702373 Positive_regulation AXIN1 CCND1 24454854 2910194 Positive_regulation AXIN2 AKT1 20578217 1237716 Positive_regulation AXIN2 AKT2 20578217 1237717 Positive_regulation AXIN2 AKT3 20578217 1237718 Positive_regulation AXIN2 APC 11524435 1274076 Positive_regulation AXIN2 APC 14551908 2255046 Positive_regulation AXIN2 APC 14551908 2255047 Positive_regulation AXIN2 APC 14551908 2255063 Positive_regulation AXIN2 APC 14551908 2255064 Positive_regulation AXIN2 APC 14551908 2255110 Positive_regulation AXIN2 APC 14551908 2255112 Positive_regulation AXIN2 APC 14551908 2255116 Positive_regulation AXIN2 APC 14551908 2255118 Positive_regulation AXIN2 APC 21980324 1239555 Positive_regulation AXIN2 APC 24594309 522889 Positive_regulation AXIN2 APC 24722208 2951005 Positive_regulation AXIN2 APC PMC3352091 2214328 Positive_regulation AXIN2 AXIN1 24722208 2951006 Positive_regulation AXIN2 AXIN2 24722208 2951007 Positive_regulation AXIN2 BAAT 23638027 2787150 Positive_regulation AXIN2 BMP4 25544567 3167866 Positive_regulation AXIN2 CAPRIN2 18762581 1357012 Positive_regulation AXIN2 CCND1 24454854 2910198 Positive_regulation AXIN2 CCNE1 24454854 2910199 Positive_regulation AXIN2 CCNE2 24454854 2910200 Positive_regulation AXIN2 CD28 20862283 2475096 Positive_regulation AXIN2 CDK5 25364642 452611 Positive_regulation AXIN2 CTNNB1 24931005 2192254 Positive_regulation AXIN2 CTNND2 24834434 190695 Positive_regulation AXIN2 DAB2 22491013 771590 Positive_regulation AXIN2 DKK1 20161711 2440474 Positive_regulation AXIN2 DVL2 25024088 1943452 Positive_regulation AXIN2 DVL2 25074807 1488176 Positive_regulation AXIN2 GNA11 22957046 2686247 Positive_regulation AXIN2 GNA11 22957046 2686328 Positive_regulation AXIN2 GNA12 22957046 2686248 Positive_regulation AXIN2 GNA12 22957046 2686329 Positive_regulation AXIN2 GNA13 22957046 2686249 Positive_regulation AXIN2 GNA13 22957046 2686330 Positive_regulation AXIN2 GNA14 22957046 2686250 Positive_regulation AXIN2 GNA14 22957046 2686331 Positive_regulation AXIN2 GNA15 22957046 2686251 Positive_regulation AXIN2 GNA15 22957046 2686332 Positive_regulation AXIN2 GNAT1 25341494 475987 Positive_regulation AXIN2 GNB1 25341494 475988 Positive_regulation AXIN2 GNGT1 25341494 475989 Positive_regulation AXIN2 GNGT2 25341494 475990 Positive_regulation AXIN2 HDAC1 23110995 3091543 Positive_regulation AXIN2 HDAC2 23110995 3091544 Positive_regulation AXIN2 HECTD1 24594309 522966 Positive_regulation AXIN2 ID1 25544567 3167868 Positive_regulation AXIN2 INS 22473005 610503 Positive_regulation AXIN2 INS 22473005 610504 Positive_regulation AXIN2 INS 22473005 610505 Positive_regulation AXIN2 INS 22473005 610506 Positive_regulation AXIN2 INS 22473005 610527 Positive_regulation AXIN2 INS 24975604 692808 Positive_regulation AXIN2 ITPR1 25124032 1210365 Positive_regulation AXIN2 LRP6 21170416 2487302 Positive_regulation AXIN2 LRP6 21887268 2548975 Positive_regulation AXIN2 LRP6 24474204 3081488 Positive_regulation AXIN2 MBP 11524435 1274065 Positive_regulation AXIN2 MCU 25124032 1210364 Positive_regulation AXIN2 MMP27 24454854 2910197 Positive_regulation AXIN2 NKD1 19888210 1903113 Positive_regulation AXIN2 NKD1 19888210 1903133 Positive_regulation AXIN2 NKD2 19888210 1903134 Positive_regulation AXIN2 NOG 23831735 1023827 Positive_regulation AXIN2 NOTCH1 17984306 1547581 Positive_regulation AXIN2 NOTCH2 17984306 1547582 Positive_regulation AXIN2 NOTCH3 17984306 1547583 Positive_regulation AXIN2 NOTCH4 17984306 1547584 Positive_regulation AXIN2 OSR1 24931004 1681300 Positive_regulation AXIN2 OXSR1 24931004 1681324 Positive_regulation AXIN2 PDCD1 11739413 1277231 Positive_regulation AXIN2 PDCD10 11739413 1277232 Positive_regulation AXIN2 PDCD11 11739413 1277230 Positive_regulation AXIN2 PDCD2 11739413 1277233 Positive_regulation AXIN2 PDCD4 11739413 1277234 Positive_regulation AXIN2 PDCD5 11739413 1277235 Positive_regulation AXIN2 PDCD6 11739413 1277236 Positive_regulation AXIN2 PDCD7 11739413 1277237 Positive_regulation AXIN2 PIK3CA 20578217 1237719 Positive_regulation AXIN2 PIK3R1 20578217 1237720 Positive_regulation AXIN2 QRICH1 22957046 2686417 Positive_regulation AXIN2 QRICH2 22957046 2686418 Positive_regulation AXIN2 RBBP4 23110995 3091545 Positive_regulation AXIN2 RBBP7 23110995 3091546 Positive_regulation AXIN2 RNF146 21799911 2539149 Positive_regulation AXIN2 RNF146 24454854 2910145 Positive_regulation AXIN2 RNF146 24454854 2910169 Positive_regulation AXIN2 RNF146 24454854 2910202 Positive_regulation AXIN2 RSPO2 23596566 942903 Positive_regulation AXIN2 SOX2 24178749 783307 Positive_regulation AXIN2 TCF12 21998560 2294883 Positive_regulation AXIN2 TCF12 22427816 2610360 Positive_regulation AXIN2 TCF12 23638027 2787139 Positive_regulation AXIN2 TCF12 23966864 2348619 Positive_regulation AXIN2 TCF12 24489983 2228236 Positive_regulation AXIN2 TCF15 21998560 2294884 Positive_regulation AXIN2 TCF15 22427816 2610361 Positive_regulation AXIN2 TCF15 23638027 2787140 Positive_regulation AXIN2 TCF15 23966864 2348620 Positive_regulation AXIN2 TCF15 24489983 2228237 Positive_regulation AXIN2 TCF19 21998560 2294885 Positive_regulation AXIN2 TCF19 22427816 2610362 Positive_regulation AXIN2 TCF19 23638027 2787141 Positive_regulation AXIN2 TCF19 23966864 2348621 Positive_regulation AXIN2 TCF19 24489983 2228238 Positive_regulation AXIN2 TCF20 21998560 2294886 Positive_regulation AXIN2 TCF20 22427816 2610363 Positive_regulation AXIN2 TCF20 23638027 2787142 Positive_regulation AXIN2 TCF20 23966864 2348622 Positive_regulation AXIN2 TCF20 24489983 2228239 Positive_regulation AXIN2 TCF21 21998560 2294887 Positive_regulation AXIN2 TCF21 22427816 2610364 Positive_regulation AXIN2 TCF21 23638027 2787143 Positive_regulation AXIN2 TCF21 23966864 2348623 Positive_regulation AXIN2 TCF21 24489983 2228240 Positive_regulation AXIN2 TCF23 21998560 2294891 Positive_regulation AXIN2 TCF23 22427816 2610368 Positive_regulation AXIN2 TCF23 23638027 2787147 Positive_regulation AXIN2 TCF23 23966864 2348627 Positive_regulation AXIN2 TCF23 24489983 2228251 Positive_regulation AXIN2 TCF24 21998560 2294893 Positive_regulation AXIN2 TCF24 22427816 2610370 Positive_regulation AXIN2 TCF24 23638027 2787149 Positive_regulation AXIN2 TCF24 23966864 2348629 Positive_regulation AXIN2 TCF24 24489983 2228253 Positive_regulation AXIN2 TCF25 21998560 2294892 Positive_regulation AXIN2 TCF25 22427816 2610369 Positive_regulation AXIN2 TCF25 23638027 2787148 Positive_regulation AXIN2 TCF25 23966864 2348628 Positive_regulation AXIN2 TCF25 24489983 2228252 Positive_regulation AXIN2 TCF3 11524435 1274056 Positive_regulation AXIN2 TCF3 21998560 2294888 Positive_regulation AXIN2 TCF3 22427816 2610365 Positive_regulation AXIN2 TCF3 23638027 2787144 Positive_regulation AXIN2 TCF3 23966864 2348624 Positive_regulation AXIN2 TCF3 24489983 2228241 Positive_regulation AXIN2 TCF4 21998560 2294889 Positive_regulation AXIN2 TCF4 22427816 2610366 Positive_regulation AXIN2 TCF4 23638027 2787145 Positive_regulation AXIN2 TCF4 23966864 2348625 Positive_regulation AXIN2 TCF4 24489983 2228242 Positive_regulation AXIN2 TCF7 21998560 2294890 Positive_regulation AXIN2 TCF7 22427816 2610367 Positive_regulation AXIN2 TCF7 23638027 2787146 Positive_regulation AXIN2 TCF7 23966864 2348626 Positive_regulation AXIN2 TCF7 24489983 2228243 Positive_regulation AXIN2 TNFRSF19 23227175 2725608 Positive_regulation AXIN2 TNKS 20676117 10562 Positive_regulation AXIN2 TNKS 22473005 610515 Positive_regulation AXIN2 TNKS2 20676117 10563 Positive_regulation AXIN2 TNKS2 21799911 2539148 Positive_regulation AXIN2 TP53 20122174 1853322 Positive_regulation AXIN2 TP53 20122174 1853326 Positive_regulation AXIN2 TP53 24932313 2168553 Positive_regulation AXIN2 WNT1 14551908 2255096 Positive_regulation AXIN2 WNT1 14551908 2255097 Positive_regulation AXIN2 WNT1 17389914 2375622 Positive_regulation AXIN2 WNT1 17961224 1645824 Positive_regulation AXIN2 WNT1 17984306 1547660 Positive_regulation AXIN2 WNT1 19225568 2405947 Positive_regulation AXIN2 WNT1 19572019 2420856 Positive_regulation AXIN2 WNT1 21880181 624037 Positive_regulation AXIN2 WNT1 22022527 2563630 Positive_regulation AXIN2 WNT1 22319467 929521 Positive_regulation AXIN2 WNT1 22457761 2613641 Positive_regulation AXIN2 WNT1 22584113 290833 Positive_regulation AXIN2 WNT1 22859735 2080083 Positive_regulation AXIN2 WNT1 22859735 2080191 Positive_regulation AXIN2 WNT1 23144924 2714890 Positive_regulation AXIN2 WNT1 23144924 2714904 Positive_regulation AXIN2 WNT1 23638027 2787118 Positive_regulation AXIN2 WNT1 23778311 1721549 Positive_regulation AXIN2 WNT1 23778311 1721686 Positive_regulation AXIN2 WNT1 24260306 2883792 Positive_regulation AXIN2 WNT1 24489983 2228244 Positive_regulation AXIN2 WNT1 24594309 522725 Positive_regulation AXIN2 WNT1 24595031 2930487 Positive_regulation AXIN2 WNT1 24596510 657534 Positive_regulation AXIN2 WNT1 24931005 2192439 Positive_regulation AXIN2 WNT1 PMC2246947 1475964 Positive_regulation AXIN2 WNT11 14551908 2255098 Positive_regulation AXIN2 WNT11 14551908 2255099 Positive_regulation AXIN2 WNT11 17389914 2375623 Positive_regulation AXIN2 WNT11 17961224 1645825 Positive_regulation AXIN2 WNT11 17984306 1547661 Positive_regulation AXIN2 WNT11 19225568 2405948 Positive_regulation AXIN2 WNT11 19572019 2420857 Positive_regulation AXIN2 WNT11 21880181 624038 Positive_regulation AXIN2 WNT11 22022527 2563631 Positive_regulation AXIN2 WNT11 22319467 929522 Positive_regulation AXIN2 WNT11 22457761 2613642 Positive_regulation AXIN2 WNT11 22584113 290834 Positive_regulation AXIN2 WNT11 22859735 2080084 Positive_regulation AXIN2 WNT11 22859735 2080192 Positive_regulation AXIN2 WNT11 23144924 2714891 Positive_regulation AXIN2 WNT11 23144924 2714905 Positive_regulation AXIN2 WNT11 23638027 2787119 Positive_regulation AXIN2 WNT11 23778311 1721550 Positive_regulation AXIN2 WNT11 23778311 1721687 Positive_regulation AXIN2 WNT11 24260306 2883793 Positive_regulation AXIN2 WNT11 24489983 2228245 Positive_regulation AXIN2 WNT11 24594309 522726 Positive_regulation AXIN2 WNT11 24595031 2930488 Positive_regulation AXIN2 WNT11 24596510 657535 Positive_regulation AXIN2 WNT11 24931005 2192440 Positive_regulation AXIN2 WNT11 PMC2246947 1475965 Positive_regulation AXIN2 WNT16 14551908 2255108 Positive_regulation AXIN2 WNT16 14551908 2255109 Positive_regulation AXIN2 WNT16 17389914 2375628 Positive_regulation AXIN2 WNT16 17961224 1645830 Positive_regulation AXIN2 WNT16 17984306 1547667 Positive_regulation AXIN2 WNT16 19225568 2405953 Positive_regulation AXIN2 WNT16 19572019 2420862 Positive_regulation AXIN2 WNT16 21880181 624043 Positive_regulation AXIN2 WNT16 22022527 2563636 Positive_regulation AXIN2 WNT16 22319467 929527 Positive_regulation AXIN2 WNT16 22457761 2613647 Positive_regulation AXIN2 WNT16 22584113 290839 Positive_regulation AXIN2 WNT16 22859735 2080089 Positive_regulation AXIN2 WNT16 22859735 2080197 Positive_regulation AXIN2 WNT16 23144924 2714896 Positive_regulation AXIN2 WNT16 23144924 2714910 Positive_regulation AXIN2 WNT16 23638027 2787124 Positive_regulation AXIN2 WNT16 23778311 1721555 Positive_regulation AXIN2 WNT16 23778311 1721692 Positive_regulation AXIN2 WNT16 24260306 2883798 Positive_regulation AXIN2 WNT16 24489983 2228250 Positive_regulation AXIN2 WNT16 24594309 522731 Positive_regulation AXIN2 WNT16 24595031 2930493 Positive_regulation AXIN2 WNT16 24596510 657540 Positive_regulation AXIN2 WNT16 24931005 2192445 Positive_regulation AXIN2 WNT16 PMC2246947 1475970 Positive_regulation AXIN2 WNT2 14551908 2255100 Positive_regulation AXIN2 WNT2 14551908 2255101 Positive_regulation AXIN2 WNT2 17389914 2375624 Positive_regulation AXIN2 WNT2 17961224 1645826 Positive_regulation AXIN2 WNT2 17984306 1547662 Positive_regulation AXIN2 WNT2 19225568 2405949 Positive_regulation AXIN2 WNT2 19572019 2420858 Positive_regulation AXIN2 WNT2 21880181 624039 Positive_regulation AXIN2 WNT2 22022527 2563632 Positive_regulation AXIN2 WNT2 22319467 929523 Positive_regulation AXIN2 WNT2 22457761 2613643 Positive_regulation AXIN2 WNT2 22584113 290835 Positive_regulation AXIN2 WNT2 22859735 2080085 Positive_regulation AXIN2 WNT2 22859735 2080193 Positive_regulation AXIN2 WNT2 23144924 2714892 Positive_regulation AXIN2 WNT2 23144924 2714906 Positive_regulation AXIN2 WNT2 23638027 2787120 Positive_regulation AXIN2 WNT2 23778311 1721551 Positive_regulation AXIN2 WNT2 23778311 1721688 Positive_regulation AXIN2 WNT2 24260306 2883794 Positive_regulation AXIN2 WNT2 24489983 2228246 Positive_regulation AXIN2 WNT2 24594309 522727 Positive_regulation AXIN2 WNT2 24595031 2930489 Positive_regulation AXIN2 WNT2 24596510 657536 Positive_regulation AXIN2 WNT2 24931005 2192441 Positive_regulation AXIN2 WNT2 PMC2246947 1475966 Positive_regulation AXIN2 WNT3 14551908 2255102 Positive_regulation AXIN2 WNT3 14551908 2255103 Positive_regulation AXIN2 WNT3 17389914 2375625 Positive_regulation AXIN2 WNT3 17961224 1645827 Positive_regulation AXIN2 WNT3 17984306 1547663 Positive_regulation AXIN2 WNT3 18955553 1359454 Positive_regulation AXIN2 WNT3 19225568 2405950 Positive_regulation AXIN2 WNT3 19572019 2420859 Positive_regulation AXIN2 WNT3 21880181 624040 Positive_regulation AXIN2 WNT3 22022527 2563633 Positive_regulation AXIN2 WNT3 22319467 929524 Positive_regulation AXIN2 WNT3 22457761 2613644 Positive_regulation AXIN2 WNT3 22584113 290836 Positive_regulation AXIN2 WNT3 22859735 2080086 Positive_regulation AXIN2 WNT3 22859735 2080194 Positive_regulation AXIN2 WNT3 23144924 2714893 Positive_regulation AXIN2 WNT3 23144924 2714907 Positive_regulation AXIN2 WNT3 23638027 2787121 Positive_regulation AXIN2 WNT3 23778311 1721552 Positive_regulation AXIN2 WNT3 23778311 1721689 Positive_regulation AXIN2 WNT3 24162018 1938497 Positive_regulation AXIN2 WNT3 24260306 2883795 Positive_regulation AXIN2 WNT3 24489983 2228247 Positive_regulation AXIN2 WNT3 24594309 522728 Positive_regulation AXIN2 WNT3 24595031 2930490 Positive_regulation AXIN2 WNT3 24596510 657537 Positive_regulation AXIN2 WNT3 24931005 2192442 Positive_regulation AXIN2 WNT3 PMC2246947 1475967 Positive_regulation AXIN2 WNT3A 17961224 1645836 Positive_regulation AXIN2 WNT3A 17984306 1547642 Positive_regulation AXIN2 WNT3A 17984306 1547666 Positive_regulation AXIN2 WNT3A 19304756 2042841 Positive_regulation AXIN2 WNT3A 19479054 2417588 Positive_regulation AXIN2 WNT3A 20694829 599154 Positive_regulation AXIN2 WNT3A 21536751 1386699 Positive_regulation AXIN2 WNT3A 21536751 1386701 Positive_regulation AXIN2 WNT3A 21611174 2523781 Positive_regulation AXIN2 WNT3A 21611174 2523782 Positive_regulation AXIN2 WNT3A 21799911 2539181 Positive_regulation AXIN2 WNT3A 21875946 1391177 Positive_regulation AXIN2 WNT3A 22479388 2615048 Positive_regulation AXIN2 WNT3A 22928951 307643 Positive_regulation AXIN2 WNT3A 23400998 1402119 Positive_regulation AXIN2 WNT3A 23675479 2793249 Positive_regulation AXIN2 WNT3A 23831735 1023826 Positive_regulation AXIN2 WNT3A 24114839 1208422 Positive_regulation AXIN2 WNT3A 24114839 1208472 Positive_regulation AXIN2 WNT3A 24114839 1208487 Positive_regulation AXIN2 WNT3A 24130821 2867162 Positive_regulation AXIN2 WNT3A 24162018 1938498 Positive_regulation AXIN2 WNT3A 24733413 2952999 Positive_regulation AXIN2 WNT3A 24842792 2971819 Positive_regulation AXIN2 WNT3A 25544567 3167867 Positive_regulation AXIN2 WNT4 14551908 2255104 Positive_regulation AXIN2 WNT4 14551908 2255105 Positive_regulation AXIN2 WNT4 17389914 2375626 Positive_regulation AXIN2 WNT4 17961224 1645828 Positive_regulation AXIN2 WNT4 17984306 1547664 Positive_regulation AXIN2 WNT4 19225568 2405951 Positive_regulation AXIN2 WNT4 19572019 2420860 Positive_regulation AXIN2 WNT4 21880181 624041 Positive_regulation AXIN2 WNT4 22022527 2563634 Positive_regulation AXIN2 WNT4 22319467 929525 Positive_regulation AXIN2 WNT4 22457761 2613645 Positive_regulation AXIN2 WNT4 22584113 290837 Positive_regulation AXIN2 WNT4 22859735 2080087 Positive_regulation AXIN2 WNT4 22859735 2080195 Positive_regulation AXIN2 WNT4 23144924 2714894 Positive_regulation AXIN2 WNT4 23144924 2714908 Positive_regulation AXIN2 WNT4 23638027 2787122 Positive_regulation AXIN2 WNT4 23778311 1721553 Positive_regulation AXIN2 WNT4 23778311 1721690 Positive_regulation AXIN2 WNT4 24260306 2883796 Positive_regulation AXIN2 WNT4 24489983 2228248 Positive_regulation AXIN2 WNT4 24594309 522729 Positive_regulation AXIN2 WNT4 24595031 2930491 Positive_regulation AXIN2 WNT4 24596510 657538 Positive_regulation AXIN2 WNT4 24931005 2192443 Positive_regulation AXIN2 WNT4 PMC2246947 1475968 Positive_regulation AXIN2 WNT6 14551908 2255106 Positive_regulation AXIN2 WNT6 14551908 2255107 Positive_regulation AXIN2 WNT6 17389914 2375627 Positive_regulation AXIN2 WNT6 17961224 1645829 Positive_regulation AXIN2 WNT6 17984306 1547665 Positive_regulation AXIN2 WNT6 19225568 2405952 Positive_regulation AXIN2 WNT6 19572019 2420861 Positive_regulation AXIN2 WNT6 21880181 624042 Positive_regulation AXIN2 WNT6 22022527 2563635 Positive_regulation AXIN2 WNT6 22319467 929526 Positive_regulation AXIN2 WNT6 22457761 2613646 Positive_regulation AXIN2 WNT6 22584113 290838 Positive_regulation AXIN2 WNT6 22859735 2080088 Positive_regulation AXIN2 WNT6 22859735 2080196 Positive_regulation AXIN2 WNT6 23144924 2714895 Positive_regulation AXIN2 WNT6 23144924 2714909 Positive_regulation AXIN2 WNT6 23638027 2787123 Positive_regulation AXIN2 WNT6 23778311 1721554 Positive_regulation AXIN2 WNT6 23778311 1721691 Positive_regulation AXIN2 WNT6 24260306 2883797 Positive_regulation AXIN2 WNT6 24489983 2228249 Positive_regulation AXIN2 WNT6 24594309 522730 Positive_regulation AXIN2 WNT6 24595031 2930492 Positive_regulation AXIN2 WNT6 24596510 657539 Positive_regulation AXIN2 WNT6 24931005 2192444 Positive_regulation AXIN2 WNT6 PMC2246947 1475969 Positive_regulation AXIN2 WNT7A 22179044 1928053 Positive_regulation AXL EPHB2 22141136 2176868 Positive_regulation AXL TLR7 23071254 1569568 Positive_regulation AXL TLR7 23071254 1569584 Positive_regulation AXL TLR7 25344858 2205858 Positive_regulation AZU1 TNF 21794177 3084321 Positive_regulation B2M TLR7 20379390 1214549 Positive_regulation B2M TNF 24839609 1621579 Positive_regulation B2M TNF 8691131 1598172 Positive_regulation B3GALT4 TNF 16100442 1634623 Positive_regulation B3GALT4 TNF 16100442 1634640 Positive_regulation BAAT PGC 22087241 2570697 Positive_regulation BAAT TNF 22297440 806716 Positive_regulation BACE1 JAG1 25621019 83109 Positive_regulation BACE1 SORL1 16930455 1890644 Positive_regulation BACE1 TNF 22047170 1660171 Positive_regulation BACE1 TNF 22047170 1660172 Positive_regulation BACE1 TNF 22047170 1660173 Positive_regulation BACE1 TNF 22047170 1660184 Positive_regulation BACE1 TNF 22047170 1660189 Positive_regulation BACE1 TNF 22047170 1660193 Positive_regulation BACE1 TNF 22047170 1660199 Positive_regulation BACE1 TNF 23964211 921911 Positive_regulation BACE2 HKDC1 23903356 728341 Positive_regulation BAD EPHB2 24182354 270313 Positive_regulation BAD MAP2K6 22096607 2571972 Positive_regulation BAG6 NES 22558287 2625008 Positive_regulation BAI1 TNF 18039391 648963 Positive_regulation BAI2 TNF 18039391 648965 Positive_regulation BAI3 TNF 18039391 648967 Positive_regulation BAIAP2 F2R 21282462 1385193 Positive_regulation BAIAP2 KANK4 19171758 1363659 Positive_regulation BAIAP2 MAP2K6 19390590 2415282 Positive_regulation BAMBI CTGF 21673687 436928 Positive_regulation BAMBI CTGF 21673687 436944 Positive_regulation BAMBI TLR7 20706677 979176 Positive_regulation BANCR EPHB2 25013510 2169230 Positive_regulation BANCR MAP2K6 25013510 2169236 Positive_regulation BANF1 FAS 22046349 2566524 Positive_regulation BANF1 FAS 22046349 2566768 Positive_regulation BAX ANGPT1 23554782 1226180 Positive_regulation BAX ANGPT1 23554782 1226192 Positive_regulation BAX ANGPT1 23554782 1226196 Positive_regulation BAX ANGPT1 23554782 1226197 Positive_regulation BAX CAPN8 20122248 1853380 Positive_regulation BAX CAPN8 20122248 1853394 Positive_regulation BAX CAPN8 20300548 1066219 Positive_regulation BAX CAPN8 22272079 1092131 Positive_regulation BAX CAPN8 24886575 3124734 Positive_regulation BAX CCND1 25105148 196086 Positive_regulation BAX CLU 24156019 492148 Positive_regulation BAX CLU 25411798 1134562 Positive_regulation BAX CTGF 24637722 2934844 Positive_regulation BAX EPHB2 21998736 2562283 Positive_regulation BAX EPHB2 24885625 314697 Positive_regulation BAX FAS 23304518 1496964 Positive_regulation BAX FAS 23901269 1137732 Positive_regulation BAX FOLR1 23319948 1674350 Positive_regulation BAX FOXO1 17081294 1845827 Positive_regulation BAX FOXO1 17081294 1845845 Positive_regulation BAX ID1 23900621 1141954 Positive_regulation BAX KRT38 12499352 1290331 Positive_regulation BAX LBP 24595452 2931334 Positive_regulation BAX MMP28 18516228 3041454 Positive_regulation BAX MMP28 24705500 1730704 Positive_regulation BAX MMP28 24959718 2983141 Positive_regulation BAX MMP7 18516228 3041469 Positive_regulation BAX MMP7 23698793 3136074 Positive_regulation BAX MMP7 24705500 1730719 Positive_regulation BAX MMP7 24959718 2983156 Positive_regulation BAX PGC 25243473 3008543 Positive_regulation BAX TNF 18246321 1644003 Positive_regulation BAX TNF 21490804 1638339 Positive_regulation BAX TNF 23728723 17885 Positive_regulation BAX TNF 23728723 17899 Positive_regulation BAX TNFSF10 17965760 810768 Positive_regulation BAX TNFSF10 17965760 810770 Positive_regulation BAX TNFSF10 20646307 256701 Positive_regulation BAX TNFSF10 20646307 256709 Positive_regulation BAX TNFSF10 20646307 256720 Positive_regulation BAX TNFSF10 21513580 1861785 Positive_regulation BAX TNFSF10 21760983 497013 Positive_regulation BAX TNFSF10 22087287 2571284 Positive_regulation BAX TNFSF10 23190604 558172 Positive_regulation BAX TNFSF10 24113173 567633 Positive_regulation BAX TNFSF10 24113173 567639 Positive_regulation BAX TP63 20429941 328900 Positive_regulation BBC3 MAP2K6 24970815 2194140 Positive_regulation BCAN MMP28 23071766 2704092 Positive_regulation BCAN MMP7 23071766 2704107 Positive_regulation BCAP29 TLR7 24740015 2954006 Positive_regulation BCAP31 TLR7 24740015 2953982 Positive_regulation BCHE MAOA 22110357 841474 Positive_regulation BCL10 CAPN8 10953012 1262239 Positive_regulation BCL10 CAPN8 22366758 1967466 Positive_regulation BCL10 CAPN8 23823868 2283321 Positive_regulation BCL10 CD22 22128838 1616575 Positive_regulation BCL10 CTGF 24637722 2934837 Positive_regulation BCL10 CTGF 24637722 2934845 Positive_regulation BCL10 EPHB2 19161638 252270 Positive_regulation BCL10 EPHB2 19305426 2124962 Positive_regulation BCL10 EPHB2 21727189 1564261 Positive_regulation BCL10 FHL1 24952875 274111 Positive_regulation BCL10 FOXO1 17081294 1845838 Positive_regulation BCL10 MAP2K6 22668349 212877 Positive_regulation BCL10 TNF 11696595 1521622 Positive_regulation BCL10 TNF 21249202 2493439 Positive_regulation BCL10 TNF 21994790 3220500 Positive_regulation BCL10 TNF 23593410 2781200 Positive_regulation BCL10 TNFSF10 18992144 251776 Positive_regulation BCL10 TNFSF10 22675673 940821 Positive_regulation BCL10 TNFSF10 22719861 2653293 Positive_regulation BCL10 TNS1 25009550 970908 Positive_regulation BCL2 ABCA4 25516716 1063630 Positive_regulation BCL2 ARSA 24586486 2925127 Positive_regulation BCL2 CAPN8 10953012 1262253 Positive_regulation BCL2 CAPN8 22366758 1967480 Positive_regulation BCL2 CAPN8 23274414 16649 Positive_regulation BCL2 CAPN8 23274414 16692 Positive_regulation BCL2 CAPN8 23823868 2283335 Positive_regulation BCL2 CD22 22128838 1616576 Positive_regulation BCL2 CTGF 24637722 2934838 Positive_regulation BCL2 CTGF 24637722 2934846 Positive_regulation BCL2 EPHB2 10359585 1511910 Positive_regulation BCL2 EPHB2 19161638 252271 Positive_regulation BCL2 EPHB2 20462959 1776082 Positive_regulation BCL2 EPHB2 20462959 1776099 Positive_regulation BCL2 EPHB2 20462959 1776100 Positive_regulation BCL2 EPHB2 20462959 1776128 Positive_regulation BCL2 EPHB2 21727189 1564265 Positive_regulation BCL2 EPHB2 22770472 532794 Positive_regulation BCL2 EPHB2 23363601 1811563 Positive_regulation BCL2 FAS 10993919 1517300 Positive_regulation BCL2 FAS 20360925 652780 Positive_regulation BCL2 FAS 22694839 406241 Positive_regulation BCL2 FAS 23202971 1098985 Positive_regulation BCL2 FAS 23468852 2759851 Positive_regulation BCL2 FHL1 24952875 274112 Positive_regulation BCL2 FOXO1 17081294 1845840 Positive_regulation BCL2 FUT4 23468946 2760260 Positive_regulation BCL2 ID1 23900621 1141955 Positive_regulation BCL2 IFI27 16839413 249518 Positive_regulation BCL2 LBP 24454506 825100 Positive_regulation BCL2 LBP 24595452 2931335 Positive_regulation BCL2 MAP2K6 20462959 1776147 Positive_regulation BCL2 MAP2K6 22668349 212884 Positive_regulation BCL2 S100B 22227007 2008245 Positive_regulation BCL2 STK39 11875716 420694 Positive_regulation BCL2 TLR7 PMC2756345 495808 Positive_regulation BCL2 TNF 11696595 1521623 Positive_regulation BCL2 TNF 21249202 2493440 Positive_regulation BCL2 TNF 21994790 3220501 Positive_regulation BCL2 TNF 23339680 3226546 Positive_regulation BCL2 TNF 23339680 3226547 Positive_regulation BCL2 TNF 23339680 3226551 Positive_regulation BCL2 TNF 23593410 2781201 Positive_regulation BCL2 TNF 24676340 1087233 Positive_regulation BCL2 TNF 9782116 1604555 Positive_regulation BCL2 TNFSF10 18992144 251778 Positive_regulation BCL2 TNFSF10 22675673 940822 Positive_regulation BCL2 TNFSF10 24113173 567642 Positive_regulation BCL2A1 CAPN8 22745672 2655762 Positive_regulation BCL2A1 TNF 11696595 1521624 Positive_regulation BCL2A1 TNF 21994790 3220502 Positive_regulation BCL2L11 FOXO1 21858169 2546788 Positive_regulation BCL3 CAPN8 10953012 1262267 Positive_regulation BCL3 CAPN8 22366758 1967494 Positive_regulation BCL3 CAPN8 23823868 2283349 Positive_regulation BCL3 CCND1 20414373 1747455 Positive_regulation BCL3 CD22 22128838 1616577 Positive_regulation BCL3 CTGF 24637722 2934839 Positive_regulation BCL3 CTGF 24637722 2934847 Positive_regulation BCL3 EPHB2 19161638 252272 Positive_regulation BCL3 EPHB2 21727189 1564269 Positive_regulation BCL3 FHL1 24952875 274113 Positive_regulation BCL3 FOXO1 17081294 1845842 Positive_regulation BCL3 MAP2K6 22668349 212891 Positive_regulation BCL3 TNF 11696595 1521625 Positive_regulation BCL3 TNF 19191868 806532 Positive_regulation BCL3 TNF 19925655 327021 Positive_regulation BCL3 TNF 21994790 3220503 Positive_regulation BCL3 TNF 23593410 2781202 Positive_regulation BCL3 TNFSF10 18992144 251780 Positive_regulation BCL3 TNFSF10 22675673 940823 Positive_regulation BCL5 CAPN8 10953012 1262183 Positive_regulation BCL5 CAPN8 22366758 1967424 Positive_regulation BCL5 CAPN8 23823868 2283279 Positive_regulation BCL5 CD22 22128838 1616572 Positive_regulation BCL5 CTGF 24637722 2934834 Positive_regulation BCL5 CTGF 24637722 2934840 Positive_regulation BCL5 EPHB2 19161638 252267 Positive_regulation BCL5 EPHB2 21727189 1564249 Positive_regulation BCL5 FHL1 24952875 274107 Positive_regulation BCL5 FOXO1 17081294 1845829 Positive_regulation BCL5 MAP2K6 22668349 212856 Positive_regulation BCL5 TNF 11696595 1521619 Positive_regulation BCL5 TNF 21994790 3220497 Positive_regulation BCL5 TNF 23593410 2781197 Positive_regulation BCL5 TNFSF10 18992144 251765 Positive_regulation BCL5 TNFSF10 22675673 940810 Positive_regulation BCL6 CAPN8 10953012 1262197 Positive_regulation BCL6 CAPN8 22366758 1967438 Positive_regulation BCL6 CAPN8 23823868 2283293 Positive_regulation BCL6 CCND1 24917186 273858 Positive_regulation BCL6 CD22 22128838 1616573 Positive_regulation BCL6 CTGF 24637722 2934835 Positive_regulation BCL6 CTGF 24637722 2934841 Positive_regulation BCL6 EPHB2 19161638 252268 Positive_regulation BCL6 EPHB2 21727189 1564253 Positive_regulation BCL6 FHL1 24952875 274108 Positive_regulation BCL6 FOXO1 17081294 1845831 Positive_regulation BCL6 FOXO1 17997602 3040246 Positive_regulation BCL6 FOXO1 21911423 1565279 Positive_regulation BCL6 FOXO1 24977668 2194651 Positive_regulation BCL6 FOXO1 24977668 2194669 Positive_regulation BCL6 HBEGF 19337254 432029 Positive_regulation BCL6 HBEGF 19337254 432049 Positive_regulation BCL6 MAP2K6 22668349 212863 Positive_regulation BCL6 TNF 11696595 1521620 Positive_regulation BCL6 TNF 21994790 3220498 Positive_regulation BCL6 TNF 23593410 2781198 Positive_regulation BCL6 TNFSF10 18992144 251767 Positive_regulation BCL6 TNFSF10 22675673 940811 Positive_regulation BCL9 CAPN8 10953012 1262211 Positive_regulation BCL9 CAPN8 22366758 1967452 Positive_regulation BCL9 CAPN8 23823868 2283307 Positive_regulation BCL9 CD22 22128838 1616574 Positive_regulation BCL9 CTGF 24637722 2934836 Positive_regulation BCL9 CTGF 24637722 2934842 Positive_regulation BCL9 EPHB2 19161638 252269 Positive_regulation BCL9 EPHB2 21727189 1564257 Positive_regulation BCL9 FHL1 24952875 274109 Positive_regulation BCL9 FOXO1 17081294 1845833 Positive_regulation BCL9 MAP2K6 22668349 212870 Positive_regulation BCL9 TNF 11696595 1521621 Positive_regulation BCL9 TNF 21994790 3220499 Positive_regulation BCL9 TNF 23593410 2781199 Positive_regulation BCL9 TNFSF10 18992144 251769 Positive_regulation BCL9 TNFSF10 22675673 940812 Positive_regulation BCR ALOX5 19503090 1948713 Positive_regulation BCR CD22 10209047 1511611 Positive_regulation BCR CD22 20098688 2437864 Positive_regulation BCR CD22 20098688 2437872 Positive_regulation BCR CD22 22566885 899275 Positive_regulation BCR CD22 22566885 899474 Positive_regulation BCR CD22 8627166 1596115 Positive_regulation BCR EPHB2 16301744 1538421 Positive_regulation BCR EPHB2 20176802 1557424 Positive_regulation BCR EPHB2 23505453 2766089 Positive_regulation BCR EPHB2 24917786 932037 Positive_regulation BCR JAG1 22908014 903690 Positive_regulation BCR JAG1 23049531 904423 Positive_regulation BCR MAP2K6 24917786 932043 Positive_regulation BCR PECAM1 23233201 1141366 Positive_regulation BCR SPHK1 24917786 932035 Positive_regulation BCR TGM2 21310073 229315 Positive_regulation BCR TLR7 19591639 116064 Positive_regulation BCR TLR7 22473011 1933689 Positive_regulation BCR TLR7 22566885 899487 Positive_regulation BCR TLR7 23505586 2371778 Positive_regulation BCR TLR7 25132836 913786 Positive_regulation BCRP1 ABCG2 24523596 2249858 Positive_regulation BCRP1 MX2 22098950 624322 Positive_regulation BCRP1 TNF 23840097 1753431 Positive_regulation BCRP2 ABCG2 24523596 2249854 Positive_regulation BCRP2 MX2 22098950 624309 Positive_regulation BCRP2 TNF 23840097 1753423 Positive_regulation BCRP3 ABCG2 24523596 2249855 Positive_regulation BCRP3 MX2 22098950 624312 Positive_regulation BCRP3 TNF 23840097 1753425 Positive_regulation BCRP4 ABCG2 24523596 2249856 Positive_regulation BCRP4 MX2 22098950 624315 Positive_regulation BCRP4 TNF 23840097 1753427 Positive_regulation BCRP5 ABCG2 24523596 2249857 Positive_regulation BCRP5 MX2 22098950 624318 Positive_regulation BCRP5 TNF 23840097 1753429 Positive_regulation BCRP6 ABCG2 24523596 2249859 Positive_regulation BCRP6 MX2 22098950 624325 Positive_regulation BCRP6 TNF 23840097 1753433 Positive_regulation BCRP7 ABCG2 24523596 2249860 Positive_regulation BCRP7 MX2 22098950 624328 Positive_regulation BCRP7 TNF 23840097 1753435 Positive_regulation BCRP8 ABCG2 24523596 2249861 Positive_regulation BCRP8 MX2 22098950 624331 Positive_regulation BCRP8 TNF 23840097 1753437 Positive_regulation BCRP9 ABCG2 24523596 2249862 Positive_regulation BCRP9 MX2 22098950 624334 Positive_regulation BCRP9 TNF 23840097 1753439 Positive_regulation BDH1 TLR7 24863067 1576518 Positive_regulation BDH1 TLR7 24863067 1576540 Positive_regulation BDKRB2 MMP28 21729302 3101199 Positive_regulation BDKRB2 MMP7 21729302 3101214 Positive_regulation BDNF CAPN8 23785661 452467 Positive_regulation BDNF EPHB2 16762058 383246 Positive_regulation BDNF EPHB2 19039330 545799 Positive_regulation BDNF EPHB2 20154710 9460 Positive_regulation BDNF EPHB2 20156366 255308 Positive_regulation BDNF EPHB2 20162012 1089288 Positive_regulation BDNF EPHB2 21562076 719197 Positive_regulation BDNF EPHB2 21779235 928016 Positive_regulation BDNF EPHB2 22144984 832238 Positive_regulation BDNF EPHB2 22952960 2685520 Positive_regulation BDNF EPHB2 23211962 1488885 Positive_regulation BDNF EPHB2 23670594 1106783 Positive_regulation BDNF EPHB2 23914898 388654 Positive_regulation BDNF EPHB2 24391468 2285179 Positive_regulation BDNF EPHB2 24396335 684876 Positive_regulation BDNF EPHB2 25249941 932979 Positive_regulation BDNF EPHB2 25426952 3030350 Positive_regulation BDNF FAS 24860731 1694779 Positive_regulation BDNF MAP2K6 23865384 388520 Positive_regulation BDNF PLAT 18813339 2396830 Positive_regulation BDNF PLAT 23423137 3189924 Positive_regulation BDNF PLAT 23519010 937815 Positive_regulation BDNF PLAT 24126929 1901322 Positive_regulation BDNF PLAT 24647528 2936198 Positive_regulation BDNF PLAT 25184365 3004819 Positive_regulation BDNF TGM2 22007160 933852 Positive_regulation BDNF TNF 21755028 1081992 Positive_regulation BDNF TNF 21958434 1659840 Positive_regulation BDNF TNF 21958434 1659852 Positive_regulation BDNF TNF 24286133 130362 Positive_regulation BDP1 EPHB2 20226026 375374 Positive_regulation BECN1 CAPN8 21490676 551691 Positive_regulation BECN1 CAPN8 22496897 2617793 Positive_regulation BECN1 CAPN8 22496897 2617824 Positive_regulation BECN1 CAPN8 24350057 946748 Positive_regulation BECN1 CTGF 22684333 541556 Positive_regulation BECN1 DAPK1 22095288 547703 Positive_regulation BECN1 DAPK1 24710486 618794 Positive_regulation BECN1 DAPK1 25278778 1478768 Positive_regulation BECN1 EPHB2 23853725 1153307 Positive_regulation BECN1 EPHB2 24053190 295052 Positive_regulation BECN1 EPHB2 24603327 572631 Positive_regulation BECN1 MAP2K6 24603327 572637 Positive_regulation BECN1 TGM2 24434788 141890 Positive_regulation BEST1 ANO1 24162234 2243586 Positive_regulation BEST2 ANO1 24162234 2243588 Positive_regulation BEST3 ANO1 24162234 2243587 Positive_regulation BGLAP FOXO1 25187705 1138330 Positive_regulation BGLAP ID1 8045940 1444364 Positive_regulation BGLAP PTGER2 21723865 850886 Positive_regulation BID FAS 11980919 1282257 Positive_regulation BID FAS 23940767 2832349 Positive_regulation BID TNF 19060883 1983095 Positive_regulation BID TNF 19060883 1983099 Positive_regulation BID TNFSF10 23828551 2183552 Positive_regulation BIRC2 EPHB2 23831571 2152763 Positive_regulation BIRC2 TNF 21799887 2538961 Positive_regulation BIRC2 TNF 23437404 2756909 Positive_regulation BIRC2 TNFSF10 20062539 2436811 Positive_regulation BIRC2 TNFSF10 24442637 773643 Positive_regulation BIRC3 TLR7 23603814 1962797 Positive_regulation BIRC3 TNF 16332260 248989 Positive_regulation BIRC3 TNF 20576118 256475 Positive_regulation BIRC3 TNF 21430708 551395 Positive_regulation BIRC3 TNF 21799887 2538962 Positive_regulation BIRC3 TNF 23437404 2756910 Positive_regulation BIRC3 TNF 24595242 1124980 Positive_regulation BIRC3 TNFSF10 20062539 2436816 Positive_regulation BIRC3 TNFSF10 20661477 2456873 Positive_regulation BIRC3 TNFSF10 24303189 2251613 Positive_regulation BLM TNF 17205112 2374058 Positive_regulation BLM TNF 17205112 2374059 Positive_regulation BMF MAP2K6 22258404 554015 Positive_regulation BMI1 ID1 24572994 1142509 Positive_regulation BMI1 ID1 24572994 1142510 Positive_regulation BMI1 ID1 24572994 1142527 Positive_regulation BMP1 EFNB1 24662724 1941113 Positive_regulation BMP1 EPHB2 22547091 601307 Positive_regulation BMP1 EPHB2 24586814 2927114 Positive_regulation BMP1 ID1 24554596 2212933 Positive_regulation BMP1 ID1 24850914 2213421 Positive_regulation BMP1 IGFBP1 23650566 2789119 Positive_regulation BMP1 JAG1 23560082 2776830 Positive_regulation BMP1 MSX1 19913215 96230 Positive_regulation BMP1 MSX1 22140629 3086115 Positive_regulation BMP1 MSX1 24550838 963730 Positive_regulation BMP1 NEDD9 24554596 2213026 Positive_regulation BMP1 NPNT 21937601 703063 Positive_regulation BMP1 STK39 21789165 2537379 Positive_regulation BMP1 STK39 24339876 2891344 Positive_regulation BMP1 TF 21978626 2112926 Positive_regulation BMP1 TF 24409331 2906941 Positive_regulation BMP1 TNF 19439035 113292 Positive_regulation BMP1 TNF 24743742 573841 Positive_regulation BMP1 TP63 23986743 879155 Positive_regulation BMP10 EPHB2 22547091 601711 Positive_regulation BMP10 ID1 24554596 2212949 Positive_regulation BMP10 ID1 24850914 2213438 Positive_regulation BMP10 IGFBP1 23650566 2789135 Positive_regulation BMP10 JAG1 23560082 2776860 Positive_regulation BMP10 MSX1 19913215 96414 Positive_regulation BMP10 MSX1 22140629 3086123 Positive_regulation BMP10 MSX1 24550838 963843 Positive_regulation BMP10 NEDD9 24554596 2213042 Positive_regulation BMP10 NPNT 21937601 703071 Positive_regulation BMP10 STK39 21789165 2537625 Positive_regulation BMP10 STK39 24339876 2891464 Positive_regulation BMP10 TF 21978626 2112944 Positive_regulation BMP10 TF 24409331 2906974 Positive_regulation BMP10 TNF 19439035 113301 Positive_regulation BMP10 TNF 24743742 573862 Positive_regulation BMP10 TP63 23986743 879163 Positive_regulation BMP15 EPHB2 22547091 601352 Positive_regulation BMP15 ID1 24554596 2212935 Positive_regulation BMP15 ID1 24850914 2213423 Positive_regulation BMP15 IGFBP1 23650566 2789121 Positive_regulation BMP15 JAG1 23560082 2776832 Positive_regulation BMP15 MSX1 19913215 96253 Positive_regulation BMP15 MSX1 22140629 3086116 Positive_regulation BMP15 MSX1 24550838 963735 Positive_regulation BMP15 NEDD9 24554596 2213028 Positive_regulation BMP15 NPNT 21937601 703064 Positive_regulation BMP15 STK39 21789165 2537394 Positive_regulation BMP15 STK39 24339876 2891359 Positive_regulation BMP15 TF 21978626 2112928 Positive_regulation BMP15 TF 24409331 2906943 Positive_regulation BMP15 TNF 19439035 113293 Positive_regulation BMP15 TNF 24743742 573843 Positive_regulation BMP15 TP63 23986743 879156 Positive_regulation BMP2 ANGPT1 25329960 3017021 Positive_regulation BMP2 EPHB2 19139264 1363536 Positive_regulation BMP2 EPHB2 22547091 601397 Positive_regulation BMP2 EPHB2 24004875 3169702 Positive_regulation BMP2 ID1 22540193 245001 Positive_regulation BMP2 ID1 22815831 2666283 Positive_regulation BMP2 ID1 24459666 186644 Positive_regulation BMP2 ID1 24554596 2212937 Positive_regulation BMP2 ID1 24850914 2213425 Positive_regulation BMP2 IGFBP1 23650566 2789123 Positive_regulation BMP2 JAG1 23560082 2776834 Positive_regulation BMP2 JAG1 23560082 2776901 Positive_regulation BMP2 MAP2K6 22870983 288736 Positive_regulation BMP2 MAP2K6 22870983 288861 Positive_regulation BMP2 MAP2K6 22870983 288971 Positive_regulation BMP2 MSX1 19913215 96276 Positive_regulation BMP2 MSX1 22140629 3086117 Positive_regulation BMP2 MSX1 24550838 963740 Positive_regulation BMP2 NEDD9 24554596 2213030 Positive_regulation BMP2 NPNT 21937601 703065 Positive_regulation BMP2 NT5E 24018651 1675556 Positive_regulation BMP2 STK39 21789165 2537409 Positive_regulation BMP2 STK39 24339876 2891374 Positive_regulation BMP2 TF 21978626 2112930 Positive_regulation BMP2 TF 24409331 2906945 Positive_regulation BMP2 TNF 19439035 113294 Positive_regulation BMP2 TNF 22363102 1749678 Positive_regulation BMP2 TNF 22513174 125527 Positive_regulation BMP2 TNF 22870983 289026 Positive_regulation BMP2 TNF 24743742 573845 Positive_regulation BMP2 TNF 24743742 573846 Positive_regulation BMP2 TNF 24743742 573914 Positive_regulation BMP2 TNF 24743742 574080 Positive_regulation BMP2 TNF 24743742 574081 Positive_regulation BMP2 TNF 25228904 914149 Positive_regulation BMP2 TNF 25228904 914175 Positive_regulation BMP2 TNF 25248109 3009284 Positive_regulation BMP2 TP63 23986743 879157 Positive_regulation BMP3 EPHB2 22547091 601442 Positive_regulation BMP3 ID1 24554596 2212939 Positive_regulation BMP3 ID1 24850914 2213427 Positive_regulation BMP3 IGFBP1 23650566 2789125 Positive_regulation BMP3 JAG1 23560082 2776836 Positive_regulation BMP3 MSX1 19913215 96299 Positive_regulation BMP3 MSX1 22140629 3086118 Positive_regulation BMP3 MSX1 24550838 963745 Positive_regulation BMP3 NEDD9 24554596 2213032 Positive_regulation BMP3 NPNT 21937601 703066 Positive_regulation BMP3 STK39 21789165 2537424 Positive_regulation BMP3 STK39 24339876 2891389 Positive_regulation BMP3 TF 21978626 2112932 Positive_regulation BMP3 TF 24409331 2906947 Positive_regulation BMP3 TNF 19439035 113295 Positive_regulation BMP3 TNF 24743742 573849 Positive_regulation BMP3 TP63 23986743 879158 Positive_regulation BMP4 CTGF 15466481 1312503 Positive_regulation BMP4 EPHB2 22547091 601487 Positive_regulation BMP4 ID1 24554596 2212941 Positive_regulation BMP4 ID1 24850914 2213429 Positive_regulation BMP4 IGFBP1 23650566 2789127 Positive_regulation BMP4 JAG1 23560082 2776838 Positive_regulation BMP4 JAG1 24391519 2355277 Positive_regulation BMP4 MSX1 16157866 2017592 Positive_regulation BMP4 MSX1 18404215 2305200 Positive_regulation BMP4 MSX1 19913215 96322 Positive_regulation BMP4 MSX1 21829537 2541637 Positive_regulation BMP4 MSX1 22140629 3086119 Positive_regulation BMP4 MSX1 22629441 2646529 Positive_regulation BMP4 MSX1 23531410 399204 Positive_regulation BMP4 MSX1 24550718 2299754 Positive_regulation BMP4 MSX1 24550838 963750 Positive_regulation BMP4 MSX1 24883034 806162 Positive_regulation BMP4 MSX1 25101640 2995801 Positive_regulation BMP4 MSX1 25101640 2995803 Positive_regulation BMP4 NEDD9 24554596 2213034 Positive_regulation BMP4 NPNT 21937601 703067 Positive_regulation BMP4 STK39 21789165 2537439 Positive_regulation BMP4 STK39 24339876 2891404 Positive_regulation BMP4 TF 21978626 2112934 Positive_regulation BMP4 TF 24409331 2906949 Positive_regulation BMP4 TNF 16542506 105641 Positive_regulation BMP4 TNF 19439035 113296 Positive_regulation BMP4 TNF 24743742 573851 Positive_regulation BMP4 TP63 23316168 960727 Positive_regulation BMP4 TP63 23316168 960728 Positive_regulation BMP4 TP63 23986743 879159 Positive_regulation BMP5 EPHB2 22547091 601532 Positive_regulation BMP5 ID1 24554596 2212943 Positive_regulation BMP5 ID1 24850914 2213431 Positive_regulation BMP5 IGFBP1 23650566 2789129 Positive_regulation BMP5 JAG1 23560082 2776840 Positive_regulation BMP5 MSX1 19913215 96345 Positive_regulation BMP5 MSX1 22140629 3086120 Positive_regulation BMP5 MSX1 24550838 963755 Positive_regulation BMP5 NEDD9 24554596 2213036 Positive_regulation BMP5 NPNT 21937601 703068 Positive_regulation BMP5 STK39 21789165 2537454 Positive_regulation BMP5 STK39 24339876 2891419 Positive_regulation BMP5 TF 21978626 2112936 Positive_regulation BMP5 TF 24409331 2906951 Positive_regulation BMP5 TNF 19439035 113297 Positive_regulation BMP5 TNF 24743742 573853 Positive_regulation BMP5 TP63 23986743 879160 Positive_regulation BMP6 EPHB2 22547091 601577 Positive_regulation BMP6 ID1 15877825 350590 Positive_regulation BMP6 ID1 15877825 350591 Positive_regulation BMP6 ID1 15877825 350592 Positive_regulation BMP6 ID1 24554596 2212945 Positive_regulation BMP6 ID1 24850914 2213433 Positive_regulation BMP6 IGFBP1 23650566 2789131 Positive_regulation BMP6 JAG1 23560082 2776842 Positive_regulation BMP6 MSX1 19913215 96368 Positive_regulation BMP6 MSX1 22140629 3086121 Positive_regulation BMP6 MSX1 24550838 963760 Positive_regulation BMP6 NEDD9 24554596 2213038 Positive_regulation BMP6 NPNT 21937601 703069 Positive_regulation BMP6 STK39 21789165 2537469 Positive_regulation BMP6 STK39 24339876 2891434 Positive_regulation BMP6 TF 21978626 2112938 Positive_regulation BMP6 TF 24409331 2906953 Positive_regulation BMP6 TNF 19439035 113298 Positive_regulation BMP6 TNF 24743742 573855 Positive_regulation BMP6 TNF 25426114 915243 Positive_regulation BMP6 TP63 23986743 879161 Positive_regulation BMP7 CTGF 21673687 436927 Positive_regulation BMP7 CTGF 21673687 436943 Positive_regulation BMP7 CTGF 21986574 13488 Positive_regulation BMP7 EPHB2 22547091 601622 Positive_regulation BMP7 ID1 20974850 1188959 Positive_regulation BMP7 ID1 24554596 2212947 Positive_regulation BMP7 ID1 24850914 2213435 Positive_regulation BMP7 IGFBP1 23650566 2789133 Positive_regulation BMP7 JAG1 23560082 2776844 Positive_regulation BMP7 MMP28 23936322 2829914 Positive_regulation BMP7 MMP7 23936322 2829929 Positive_regulation BMP7 MSX1 19913215 96391 Positive_regulation BMP7 MSX1 22140629 3086122 Positive_regulation BMP7 MSX1 23316168 960729 Positive_regulation BMP7 MSX1 23316168 960737 Positive_regulation BMP7 MSX1 24550838 963765 Positive_regulation BMP7 NEDD9 24554596 2213040 Positive_regulation BMP7 NPNT 21937601 703070 Positive_regulation BMP7 STK39 21789165 2537484 Positive_regulation BMP7 STK39 24339876 2891449 Positive_regulation BMP7 TF 21978626 2112940 Positive_regulation BMP7 TF 24409331 2906955 Positive_regulation BMP7 TNF 19439035 113299 Positive_regulation BMP7 TNF 24743742 573857 Positive_regulation BMP7 TP63 23986743 879162 Positive_regulation BMPR1A ANGPT1 22539968 2622653 Positive_regulation BMPR1A ID1 17509151 1999795 Positive_regulation BMX F2R 21318117 2234218 Positive_regulation BNIP3 CTGF 22684333 541547 Positive_regulation BNIP3 CTGF 22684333 541557 Positive_regulation BOC CAPN8 21765948 2536598 Positive_regulation BPI CEBPA 24658030 2937316 Positive_regulation BPI INS 21266327 717055 Positive_regulation BPI PRPS1 22783227 925156 Positive_regulation BPI PRPS2 22783227 925157 Positive_regulation BPI TLR8 23626859 2785157 Positive_regulation BPIFA1 IFI27 23472073 2763824 Positive_regulation BPNT1 CD14 22570785 1688461 Positive_regulation BPNT1 EPHB2 17597926 162770 Positive_regulation BPNT1 EPHB2 22817771 471853 Positive_regulation BPNT1 EPHB2 22817771 471873 Positive_regulation BPNT1 EPHB2 22817771 471877 Positive_regulation BPNT1 F2R 21827709 1835929 Positive_regulation BPNT1 FOXO1 20028942 712396 Positive_regulation BPNT1 PIWIL4 20011505 2312061 Positive_regulation BPNT1 SCIN 24155741 879366 Positive_regulation BRAF EPHB2 18332218 1349867 Positive_regulation BRAF EPHB2 18335053 2387093 Positive_regulation BRAF EPHB2 19828018 1696418 Positive_regulation BRAF EPHB2 21203386 2489582 Positive_regulation BRAF EPHB2 23617957 1617864 Positive_regulation BRAF EPHB2 25344914 2206023 Positive_regulation BRAF MAP2K6 17958888 1242699 Positive_regulation BRAF MAP2K6 19828018 1696424 Positive_regulation BRAF MAP2K6 21203386 2489588 Positive_regulation BRAF MAP2K6 21383698 2138615 Positive_regulation BRAF MAP2K6 21411864 2175678 Positive_regulation BRAF MAP2K6 23085539 2181462 Positive_regulation BRAF MAP2K6 23642906 625562 Positive_regulation BRAF MAP2K6 23826126 2810473 Positive_regulation BRAF MAP2K6 24194739 909642 Positive_regulation BRAF MAP2K6 24810962 2190396 Positive_regulation BRAF MAP2K6 25074438 1702364 Positive_regulation BRAF MAP2K6 25228592 2200189 Positive_regulation BRAF MAP2K6 25228592 2200203 Positive_regulation BRAP TLR7 22484733 1957103 Positive_regulation BRCA1 CCND1 PMC3300725 477058 Positive_regulation BRCA1 NES 25594072 788850 Positive_regulation BRCA1 TP63 23863842 2091411 Positive_regulation BRD7 EPHB2 24404152 2906085 Positive_regulation BRF1 EPHB2 20226026 375373 Positive_regulation BRINP3 TNF 25251368 3010086 Positive_regulation BRINP3 TNF 25251368 3010087 Positive_regulation BRINP3 TNF 25251368 3010090 Positive_regulation BRMS1 TNF 21765477 2141248 Positive_regulation BRMS1 TNF 21765477 2141280 Positive_regulation BSG EPHB2 20107538 1037438 Positive_regulation BSG MMP28 16207318 104083 Positive_regulation BSG MMP28 16207318 104127 Positive_regulation BSG MMP28 20540754 3098475 Positive_regulation BSG MMP28 24281180 502110 Positive_regulation BSG MMP7 16207318 104098 Positive_regulation BSG MMP7 16207318 104142 Positive_regulation BSG MMP7 20540754 3098490 Positive_regulation BSG MMP7 24281180 502125 Positive_regulation BSG SLC16A3 20454640 1215236 Positive_regulation BSN HBEGF 20946648 1859868 Positive_regulation BSN WNT7A 25170755 3003885 Positive_regulation BST2 TNF 23240078 3131878 Positive_regulation BTK TLR7 25170774 3003952 Positive_regulation BTK TNFSF10 15007095 1531777 Positive_regulation BTRC ABCG2 22252524 3204978 Positive_regulation BTRC EPHB2 21559359 2518493 Positive_regulation BUD13 FOXO1 21689484 404980 Positive_regulation BUD31 FOXO1 21689484 404982 Positive_regulation C1orf228 TLR7 17485511 1545614 Positive_regulation C1orf228 TLR7 19609356 3044584 Positive_regulation C1orf228 TLR7 23162549 905011 Positive_regulation C1orf228 TLR7 24379524 1756087 Positive_regulation C1orf228 TNF 11157054 1518353 Positive_regulation C1orf228 TNF 25552899 744125 Positive_regulation C1orf228 TP63 23221473 3217378 Positive_regulation C1QA TNF 24252536 5828 Positive_regulation C1QB TNF 24252536 5830 Positive_regulation C1S TNF 22028815 2564412 Positive_regulation C3 CFI 21445332 2370064 Positive_regulation C3 CFI 21445332 2370066 Positive_regulation C3 CFI 21445332 2370067 Positive_regulation C3 CFI 21902819 2221027 Positive_regulation C3 CFI 23479095 1992531 Positive_regulation C3 CFI 24161035 3158331 Positive_regulation C3 CFI 24161037 3158340 Positive_regulation C3 CFI 25188723 216230 Positive_regulation C3 GPR115 24743347 2955087 Positive_regulation C3 GPR132 24743347 2955076 Positive_regulation C3 GPR87 24743347 2955156 Positive_regulation C3 IFI27 23760402 1721304 Positive_regulation C3 IFI27 25265036 3011120 Positive_regulation C3 TNF 22264230 124591 Positive_regulation C3 TNF 23840379 2812663 Positive_regulation C4A TNF 24789665 1886434 Positive_regulation C4B CFI 21445332 2370061 Positive_regulation C4B CFI 21445332 2370065 Positive_regulation C4B CFI 21445332 2370068 Positive_regulation C4B CFI 24161037 3158341 Positive_regulation C4B CFI 702059 1586830 Positive_regulation C4B CFI 702059 1586831 Positive_regulation C4B CFI 702059 1586832 Positive_regulation C4B IFI27 25265036 3011126 Positive_regulation C4B KCP 20657771 2456415 Positive_regulation C4B SERPINA5 20308361 1557841 Positive_regulation C4B TNF 23326670 3081102 Positive_regulation C4BPA CFI 7019379 1586824 Positive_regulation C4BPA F2R 21489985 1191350 Positive_regulation C5 EPHB2 24523571 1757458 Positive_regulation C5 EPHB2 24523571 1757463 Positive_regulation C5 SPHK1 22355325 2597220 Positive_regulation C5 TNF 20652897 774885 Positive_regulation C5 TNF 24711204 492727 Positive_regulation C5 TNF 3260938 1580647 Positive_regulation C5AR1 PLAU 20196869 118388 Positive_regulation C5AR2 EPHB2 24523571 1757464 Positive_regulation C5AR2 SPHK1 22355325 2597208 Positive_regulation C5AR2 SPHK1 22355325 2597213 Positive_regulation C9orf3 FAS 18715501 166121 Positive_regulation CA12 GDF6 24618041 132044 Positive_regulation CA12 MT-CO2 19333419 1088102 Positive_regulation CA12 SLC4A3 23297731 275199 Positive_regulation CA12 SLC9A1 23297731 275200 Positive_regulation CA12 SOST 24395179 478025 Positive_regulation CA12 TNFSF11 21955617 124090 Positive_regulation CA2 ABCA4 12093870 1523915 Positive_regulation CA2 ALOX5 25452755 921333 Positive_regulation CA2 ANO1 21642943 12807 Positive_regulation CA2 ANO1 24420770 1611149 Positive_regulation CA2 ANO1 24420770 1611150 Positive_regulation CA2 ANO1 24420770 1611217 Positive_regulation CA2 ANO1 24489780 2916226 Positive_regulation CA2 ANO1 24489780 2916233 Positive_regulation CA2 ANO1 24901998 2977021 Positive_regulation CA2 ANO1 24901998 2977022 Positive_regulation CA2 ANO1 24901998 2977038 Positive_regulation CA2 CAPN8 11121441 1265840 Positive_regulation CA2 CAPN8 11934353 389469 Positive_regulation CA2 CAPN8 12379807 1287172 Positive_regulation CA2 CAPN8 16776830 383424 Positive_regulation CA2 CAPN8 19693274 2424244 Positive_regulation CA2 CAPN8 20300548 1066193 Positive_regulation CA2 CAPN8 20878536 599492 Positive_regulation CA2 CAPN8 21390223 2506243 Positive_regulation CA2 CAPN8 21516125 2139163 Positive_regulation CA2 CAPN8 22232700 1394750 Positive_regulation CA2 CAPN8 22496638 3055942 Positive_regulation CA2 CAPN8 22496638 3055968 Positive_regulation CA2 CAPN8 22685624 2224348 Positive_regulation CA2 CAPN8 23596505 2781852 Positive_regulation CA2 CAPN8 23698771 1107130 Positive_regulation CA2 CAPN8 23840759 2816335 Positive_regulation CA2 CAPN8 24434516 570932 Positive_regulation CA2 CAPN8 24971566 2984714 Positive_regulation CA2 CD14 22719740 901953 Positive_regulation CA2 CD14 23898465 864147 Positive_regulation CA2 CTGF 24244587 2880488 Positive_regulation CA2 CYP24A1 23497279 268035 Positive_regulation CA2 EDN2 24470488 1611248 Positive_regulation CA2 EDN2 9413947 446776 Positive_regulation CA2 EDN2 PMC3016524 391064 Positive_regulation CA2 EPHB2 19432968 373107 Positive_regulation CA2 EPHB2 20858281 1859194 Positive_regulation CA2 EPHB2 23533483 817823 Positive_regulation CA2 EPHB2 23710457 181743 Positive_regulation CA2 EPHB2 24184055 1041133 Positive_regulation CA2 EPHB2 9763608 1604065 Positive_regulation CA2 F2R 21827709 1835924 Positive_regulation CA2 F2R 21827709 1835925 Positive_regulation CA2 F2R 21827709 1835926 Positive_regulation CA2 F2R 21827709 1835930 Positive_regulation CA2 F2R 21827709 1835932 Positive_regulation CA2 F2R 21827709 1835934 Positive_regulation CA2 F2R 23405206 2752028 Positive_regulation CA2 F2R 24321245 1842795 Positive_regulation CA2 F2R 24409095 2285220 Positive_regulation CA2 F2R 24860547 880593 Positive_regulation CA2 F2R 24943270 1942619 Positive_regulation CA2 F2R 25364818 3021833 Positive_regulation CA2 F2R 8642286 1596690 Positive_regulation CA2 FAS 21713032 2276632 Positive_regulation CA2 FAS 21713032 2276633 Positive_regulation CA2 FAS 21713032 2276634 Positive_regulation CA2 FAS 21713032 2276645 Positive_regulation CA2 FOXO1 21694754 2528989 Positive_regulation CA2 GJB2 20584891 1609779 Positive_regulation CA2 GJB2 24465148 842090 Positive_regulation CA2 GLP1R 19593440 2421481 Positive_regulation CA2 GLP1R 21716694 831646 Positive_regulation CA2 GLP1R 21716694 831717 Positive_regulation CA2 GLP1R 22611375 833069 Positive_regulation CA2 GLP1R 23094100 2706015 Positive_regulation CA2 GPR115 16009725 1321335 Positive_regulation CA2 GPR115 18454189 2388157 Positive_regulation CA2 GPR115 25302070 2114097 Positive_regulation CA2 GPR115 25598665 1716925 Positive_regulation CA2 GPR115 7843095 796534 Positive_regulation CA2 GPR132 16009725 1321324 Positive_regulation CA2 GPR132 18454189 2388146 Positive_regulation CA2 GPR132 25302070 2114086 Positive_regulation CA2 GPR132 25598665 1716914 Positive_regulation CA2 GPR132 7843095 796523 Positive_regulation CA2 GPR87 16009725 1321404 Positive_regulation CA2 GPR87 18454189 2388226 Positive_regulation CA2 GPR87 25302070 2114166 Positive_regulation CA2 GPR87 25598665 1716994 Positive_regulation CA2 GPR87 7843095 796603 Positive_regulation CA2 HRH1 24709960 618012 Positive_regulation CA2 ITGAL 2569026 1577444 Positive_regulation CA2 ITGAL 2569026 1577446 Positive_regulation CA2 ITGB2 2569026 1577445 Positive_regulation CA2 LPCAT1 22676268 229981 Positive_regulation CA2 LPCAT1 22676268 229991 Positive_regulation CA2 MAP2K6 21943104 387277 Positive_regulation CA2 MMP28 22536507 154834 Positive_regulation CA2 MMP7 22536507 154849 Positive_regulation CA2 PGC 24832661 177126 Positive_regulation CA2 RASA3 9874690 1612992 Positive_regulation CA2 RCAN1 22461792 680251 Positive_regulation CA2 RIC3 15824136 1319920 Positive_regulation CA2 RIC3 15824136 1319929 Positive_regulation CA2 RIC3 15824136 1319936 Positive_regulation CA2 RIC3 15824136 1319937 Positive_regulation CA2 RIC3 18591430 1353358 Positive_regulation CA2 RIC3 18591430 1353359 Positive_regulation CA2 RIC3 20522555 1188050 Positive_regulation CA2 S100B 20827311 512995 Positive_regulation CA2 S100B 24723847 931605 Positive_regulation CA2 S100B 24860604 980930 Positive_regulation CA2 S1PR3 21687504 950263 Positive_regulation CA2 SCIN 1331119 1297602 Positive_regulation CA2 SYT8 25206473 2004703 Positive_regulation CA2 TMOD1 10085296 1244336 Positive_regulation CA2 TMOD1 17630823 2289432 Positive_regulation CA2 TMOD1 1940850 1609349 Positive_regulation CA2 TMOD1 20584889 1609746 Positive_regulation CA2 TMOD1 21727195 1389793 Positive_regulation CA2 TMOD1 23401574 1610459 Positive_regulation CA2 TNF 1658188 1539817 Positive_regulation CA2 TNF 1658188 1539819 Positive_regulation CA2 TNF 19281093 1071724 Positive_regulation CA2 TNF 19695100 1897442 Positive_regulation CA2 TNF 19695100 1897452 Positive_regulation CA2 TNF 24278460 2885981 Positive_regulation CA2 TNF 24303157 2251411 Positive_regulation CA2 TNF 24466329 2914348 Positive_regulation CA2 TNF 24466329 2914350 Positive_regulation CA2 TNF 24466329 2914361 Positive_regulation CA2 TNF 24466329 2914365 Positive_regulation CA2 TNF 24475162 2915019 Positive_regulation CA2 TNF 24993127 396118 Positive_regulation CA2 TNF 25566088 967313 Positive_regulation CA7 TNF 23193206 729918 Positive_regulation CA7 TNF 23193206 729919 Positive_regulation CA8 ANKRD1 25089522 2994534 Positive_regulation CA8 TNF 22815752 2665964 Positive_regulation CAD EPHB2 19834610 2428791 Positive_regulation CAD EPHB2 19834610 2428792 Positive_regulation CAD EPHB2 19834610 2428793 Positive_regulation CADM1 IL1B 18472842 1742247 Positive_regulation CADM1 TNF 12823845 99838 Positive_regulation CADM1 TNF 18472842 1742245 Positive_regulation CADM1 TNF 19709415 365698 Positive_regulation CADM1 TNF 23728723 17884 Positive_regulation CADM1 TNF 23987139 412466 Positive_regulation CADM1 TNF 25517907 3035026 Positive_regulation CADM1 TNF 8315391 1594882 Positive_regulation CADM2 IL1B 18472842 1742239 Positive_regulation CADM2 TNF 18472842 1742237 Positive_regulation CADM2 TNF 19709415 365696 Positive_regulation CADM2 TNF 23728723 17881 Positive_regulation CADM2 TNF 23987139 412462 Positive_regulation CADM2 TNF 25517907 3035024 Positive_regulation CADM2 TNF 8315391 1594875 Positive_regulation CADM3 IL1B 18472842 1742235 Positive_regulation CADM3 TNF 18472842 1742233 Positive_regulation CADM3 TNF 19709415 365695 Positive_regulation CADM3 TNF 23728723 17880 Positive_regulation CADM3 TNF 23987139 412461 Positive_regulation CADM3 TNF 25517907 3035023 Positive_regulation CADM3 TNF 8315391 1594874 Positive_regulation CADM4 IL1B 18472842 1742243 Positive_regulation CADM4 TNF 18472842 1742241 Positive_regulation CADM4 TNF 19709415 365697 Positive_regulation CADM4 TNF 23728723 17882 Positive_regulation CADM4 TNF 23987139 412463 Positive_regulation CADM4 TNF 25517907 3035025 Positive_regulation CADM4 TNF 8315391 1594876 Positive_regulation CALCA GLP1R 20103558 729493 Positive_regulation CALCA GLP1R 22693487 833126 Positive_regulation CALCA GLP1R 22693487 833130 Positive_regulation CALCA GLP1R 22693487 833131 Positive_regulation CALCA NEDD9 25594051 2173952 Positive_regulation CALCR ITGB2 23959798 1880513 Positive_regulation CALD1 EDN2 18475617 1744667 Positive_regulation CALD1 MAP2K6 22363435 2599030 Positive_regulation CALM3 ANO1 21642943 12809 Positive_regulation CALM3 ANO1 24420770 1611151 Positive_regulation CALM3 ANO1 24420770 1611168 Positive_regulation CALM3 ANO1 24420770 1611219 Positive_regulation CALM3 TNF 17116732 1543370 Positive_regulation CALM3 TNF 17116732 1543372 Positive_regulation CALM3 TNF 22125674 2115072 Positive_regulation CALM3 TNF 22125674 2115076 Positive_regulation CALM3 TNF 23788975 657475 Positive_regulation CALM3 TNF 24222847 627871 Positive_regulation CALM3 TNF 24968272 1127938 Positive_regulation CALM3 TNF 24968272 1127943 Positive_regulation CALML3 MMP28 21591259 776173 Positive_regulation CALML3 MMP7 21591259 776188 Positive_regulation CALR FAS 23060904 882979 Positive_regulation CALR TNF 23651618 3085069 Positive_regulation CAMK2A F2R 21941675 1082224 Positive_regulation CAMKK1 EPHB2 20802521 2135516 Positive_regulation CAMKK2 EPHB2 20802521 2135519 Positive_regulation CAMP CD14 19607716 325815 Positive_regulation CAMP CD14 21049021 2480508 Positive_regulation CAMP CYP24A1 23424670 2755212 Positive_regulation CAMP CYP24A1 23805323 2808448 Positive_regulation CAMP EPHB2 21685939 2140296 Positive_regulation CAMP EPHB2 21685939 2140319 Positive_regulation CAMP EPHB2 23856934 1632264 Positive_regulation CAMP HBEGF 20195469 2441892 Positive_regulation CAMP LBP 21049021 2480509 Positive_regulation CAMP MMP28 22336948 1630670 Positive_regulation CAMP MMP7 22336948 1630685 Positive_regulation CAMP MUC16 19728885 365701 Positive_regulation CAMP TLR7 19703986 1555989 Positive_regulation CAMP TLR7 19703986 1555990 Positive_regulation CAMP TLR7 22286305 1962064 Positive_regulation CAMP TLR7 25089904 2994771 Positive_regulation CAMP TNF 20182640 631853 Positive_regulation CAMP TNF 21904619 2550528 Positive_regulation CAMP TNF 2549168 1577359 Positive_regulation CANX EPHB2 21219631 258376 Positive_regulation CANX EPHB2 21776388 1686273 Positive_regulation CANX EPHB2 22905122 2675381 Positive_regulation CANX EPHB2 24330599 388951 Positive_regulation CANX EPHB2 24330599 388960 Positive_regulation CANX EPHB2 24330599 388968 Positive_regulation CANX EPHB2 24552586 389099 Positive_regulation CANX MAP2K6 22979979 406995 Positive_regulation CANX MAP2K6 24159358 823172 Positive_regulation CANX PLAT 25514242 1135691 Positive_regulation CAPN1 CCND1 24999379 2229459 Positive_regulation CAPN1 EPHB2 20937704 1560788 Positive_regulation CAPN1 EPHB2 21048967 2480300 Positive_regulation CAPN1 EPHB2 24586666 2926110 Positive_regulation CAPN1 SMN2 22607171 150398 Positive_regulation CAPN1 TNF 19266085 1671045 Positive_regulation CAPN1 TNF 19266085 1671059 Positive_regulation CAPN1 TNF 22451727 1713289 Positive_regulation CAPN1 TNF 24026771 1890378 Positive_regulation CAPN10 CCND1 24999379 2229462 Positive_regulation CAPN10 EPHB2 20937704 1560802 Positive_regulation CAPN10 EPHB2 21048967 2480301 Positive_regulation CAPN10 EPHB2 24586666 2926111 Positive_regulation CAPN10 SMN2 22607171 150408 Positive_regulation CAPN10 TNF 19266085 1671046 Positive_regulation CAPN10 TNF 19266085 1671060 Positive_regulation CAPN10 TNF 22451727 1713290 Positive_regulation CAPN10 TNF 24026771 1890380 Positive_regulation CAPN11 CCND1 24999379 2229465 Positive_regulation CAPN11 EPHB2 20937704 1560816 Positive_regulation CAPN11 EPHB2 21048967 2480302 Positive_regulation CAPN11 EPHB2 24586666 2926112 Positive_regulation CAPN11 SMN2 22607171 150418 Positive_regulation CAPN11 TNF 19266085 1671047 Positive_regulation CAPN11 TNF 19266085 1671061 Positive_regulation CAPN11 TNF 22451727 1713291 Positive_regulation CAPN11 TNF 24026771 1890382 Positive_regulation CAPN12 CCND1 24999379 2229456 Positive_regulation CAPN12 EPHB2 20937704 1560774 Positive_regulation CAPN12 EPHB2 21048967 2480299 Positive_regulation CAPN12 EPHB2 24586666 2926109 Positive_regulation CAPN12 SMN2 22607171 150388 Positive_regulation CAPN12 TNF 19266085 1671044 Positive_regulation CAPN12 TNF 19266085 1671058 Positive_regulation CAPN12 TNF 22451727 1713288 Positive_regulation CAPN12 TNF 24026771 1890376 Positive_regulation CAPN13 CCND1 24999379 2229492 Positive_regulation CAPN13 EPHB2 20937704 1560928 Positive_regulation CAPN13 EPHB2 21048967 2480310 Positive_regulation CAPN13 EPHB2 24586666 2926120 Positive_regulation CAPN13 SMN2 22607171 150498 Positive_regulation CAPN13 TNF 19266085 1671055 Positive_regulation CAPN13 TNF 19266085 1671069 Positive_regulation CAPN13 TNF 22451727 1713299 Positive_regulation CAPN13 TNF 24026771 1890398 Positive_regulation CAPN14 CCND1 24999379 2229495 Positive_regulation CAPN14 EPHB2 20937704 1560942 Positive_regulation CAPN14 EPHB2 21048967 2480311 Positive_regulation CAPN14 EPHB2 24586666 2926121 Positive_regulation CAPN14 SMN2 22607171 150508 Positive_regulation CAPN14 TNF 19266085 1671056 Positive_regulation CAPN14 TNF 19266085 1671070 Positive_regulation CAPN14 TNF 22451727 1713300 Positive_regulation CAPN14 TNF 24026771 1890400 Positive_regulation CAPN15 CCND1 24999379 2229453 Positive_regulation CAPN15 EPHB2 20937704 1560760 Positive_regulation CAPN15 EPHB2 21048967 2480298 Positive_regulation CAPN15 EPHB2 24586666 2926108 Positive_regulation CAPN15 SMN2 22607171 150378 Positive_regulation CAPN15 TNF 19266085 1671043 Positive_regulation CAPN15 TNF 19266085 1671057 Positive_regulation CAPN15 TNF 22451727 1713287 Positive_regulation CAPN15 TNF 24026771 1890374 Positive_regulation CAPN2 CAPN8 16433929 298622 Positive_regulation CAPN2 CAPN8 18802475 1055023 Positive_regulation CAPN2 CCND1 24999379 2229468 Positive_regulation CAPN2 EPHB2 20847951 1672448 Positive_regulation CAPN2 EPHB2 20937704 1560830 Positive_regulation CAPN2 EPHB2 21048967 2480303 Positive_regulation CAPN2 EPHB2 22310287 2146239 Positive_regulation CAPN2 EPHB2 22319531 1067208 Positive_regulation CAPN2 EPHB2 22808288 2665368 Positive_regulation CAPN2 EPHB2 22815829 2666234 Positive_regulation CAPN2 EPHB2 24586666 2926113 Positive_regulation CAPN2 EPHB2 24611062 880332 Positive_regulation CAPN2 SMN2 22607171 150428 Positive_regulation CAPN2 TNF 19266085 1671048 Positive_regulation CAPN2 TNF 19266085 1671062 Positive_regulation CAPN2 TNF 22451727 1713292 Positive_regulation CAPN2 TNF 24026771 1890384 Positive_regulation CAPN3 CCND1 24999379 2229471 Positive_regulation CAPN3 EPHB2 20937704 1560844 Positive_regulation CAPN3 EPHB2 21048967 2480304 Positive_regulation CAPN3 EPHB2 24586666 2926114 Positive_regulation CAPN3 SMN2 22607171 150438 Positive_regulation CAPN3 TNF 19266085 1671049 Positive_regulation CAPN3 TNF 19266085 1671063 Positive_regulation CAPN3 TNF 22451727 1713293 Positive_regulation CAPN3 TNF 24026771 1890386 Positive_regulation CAPN5 CCND1 24999379 2229474 Positive_regulation CAPN5 EPHB2 20937704 1560858 Positive_regulation CAPN5 EPHB2 21048967 2480305 Positive_regulation CAPN5 EPHB2 24586666 2926115 Positive_regulation CAPN5 SMN2 22607171 150448 Positive_regulation CAPN5 TNF 19266085 1671050 Positive_regulation CAPN5 TNF 19266085 1671064 Positive_regulation CAPN5 TNF 22451727 1713294 Positive_regulation CAPN5 TNF 24026771 1890388 Positive_regulation CAPN6 CCND1 24999379 2229477 Positive_regulation CAPN6 EPHB2 20937704 1560872 Positive_regulation CAPN6 EPHB2 21048967 2480306 Positive_regulation CAPN6 EPHB2 24586666 2926116 Positive_regulation CAPN6 SMN2 22607171 150458 Positive_regulation CAPN6 TNF 19266085 1671051 Positive_regulation CAPN6 TNF 19266085 1671065 Positive_regulation CAPN6 TNF 22451727 1713295 Positive_regulation CAPN6 TNF 24026771 1890390 Positive_regulation CAPN7 CCND1 24999379 2229480 Positive_regulation CAPN7 EPHB2 20937704 1560886 Positive_regulation CAPN7 EPHB2 21048967 2480307 Positive_regulation CAPN7 EPHB2 24586666 2926117 Positive_regulation CAPN7 SMN2 22607171 150468 Positive_regulation CAPN7 TNF 19266085 1671052 Positive_regulation CAPN7 TNF 19266085 1671066 Positive_regulation CAPN7 TNF 22451727 1713296 Positive_regulation CAPN7 TNF 24026771 1890392 Positive_regulation CAPN8 ABCD1 24551180 2923293 Positive_regulation CAPN8 ACTL6A 24811485 2190898 Positive_regulation CAPN8 AHR 25068070 1242185 Positive_regulation CAPN8 ANGPT2 18493299 2388936 Positive_regulation CAPN8 ANXA1 11489944 1520025 Positive_regulation CAPN8 APOB 18624772 1478945 Positive_regulation CAPN8 ARID1A 24811485 2190897 Positive_regulation CAPN8 BAX 20122248 1853366 Positive_regulation CAPN8 BAX 24963283 842477 Positive_regulation CAPN8 BCL2 23274414 16678 Positive_regulation CAPN8 BPNT1 PMC2173748 1475037 Positive_regulation CAPN8 CA2 10790426 1515294 Positive_regulation CAPN8 CA2 11934353 389481 Positive_regulation CAPN8 CA2 12379807 1287158 Positive_regulation CAPN8 CA2 1378447 1297930 Positive_regulation CAPN8 CA2 14606958 523428 Positive_regulation CAPN8 CA2 16097482 2001737 Positive_regulation CAPN8 CA2 18624772 1478944 Positive_regulation CAPN8 CA2 18803809 1832761 Positive_regulation CAPN8 CA2 18803809 1832775 Positive_regulation CAPN8 CA2 18803809 1832803 Positive_regulation CAPN8 CA2 19517010 2418729 Positive_regulation CAPN8 CA2 19997503 3045731 Positive_regulation CAPN8 CA2 19997503 3045745 Positive_regulation CAPN8 CA2 20122248 1853339 Positive_regulation CAPN8 CA2 20300548 1066205 Positive_regulation CAPN8 CA2 20485565 3046896 Positive_regulation CAPN8 CA2 20485565 3046910 Positive_regulation CAPN8 CA2 20878536 599504 Positive_regulation CAPN8 CA2 20949071 3048927 Positive_regulation CAPN8 CA2 21152086 2486156 Positive_regulation CAPN8 CA2 21156051 3111807 Positive_regulation CAPN8 CA2 21410437 148431 Positive_regulation CAPN8 CA2 21516125 2139183 Positive_regulation CAPN8 CA2 21516125 2139296 Positive_regulation CAPN8 CA2 21633391 552230 Positive_regulation CAPN8 CA2 21633391 552244 Positive_regulation CAPN8 CA2 21687749 2232438 Positive_regulation CAPN8 CA2 21738275 1713150 Positive_regulation CAPN8 CA2 21765834 2119765 Positive_regulation CAPN8 CA2 22069558 3181611 Positive_regulation CAPN8 CA2 22069558 3181630 Positive_regulation CAPN8 CA2 22069648 3183033 Positive_regulation CAPN8 CA2 22069695 3183471 Positive_regulation CAPN8 CA2 22168362 137911 Positive_regulation CAPN8 CA2 22190742 1799245 Positive_regulation CAPN8 CA2 22232700 1394762 Positive_regulation CAPN8 CA2 22496638 3055954 Positive_regulation CAPN8 CA2 22563421 2626411 Positive_regulation CAPN8 CA2 22613960 1140876 Positive_regulation CAPN8 CA2 22654658 3056883 Positive_regulation CAPN8 CA2 22864302 15825 Positive_regulation CAPN8 CA2 22931549 2233457 Positive_regulation CAPN8 CA2 22967854 406901 Positive_regulation CAPN8 CA2 23208374 1099902 Positive_regulation CAPN8 CA2 23363708 1728249 Positive_regulation CAPN8 CA2 23551528 1480277 Positive_regulation CAPN8 CA2 23594099 1232015 Positive_regulation CAPN8 CA2 23594099 1232032 Positive_regulation CAPN8 CA2 23594099 1232049 Positive_regulation CAPN8 CA2 23596505 2781824 Positive_regulation CAPN8 CA2 23682710 89833 Positive_regulation CAPN8 CA2 23734212 2799632 Positive_regulation CAPN8 CA2 23772679 138648 Positive_regulation CAPN8 CA2 23840759 2816347 Positive_regulation CAPN8 CA2 23840759 2816361 Positive_regulation CAPN8 CA2 23847618 908111 Positive_regulation CAPN8 CA2 23940116 1407186 Positive_regulation CAPN8 CA2 24089642 2003247 Positive_regulation CAPN8 CA2 24259890 1682260 Positive_regulation CAPN8 CA2 24416390 2908251 Positive_regulation CAPN8 CA2 24567703 868779 Positive_regulation CAPN8 CA2 24624086 953652 Positive_regulation CAPN8 CA2 24707444 1490921 Positive_regulation CAPN8 CA2 24888514 3085537 Positive_regulation CAPN8 CA2 24902695 1896057 Positive_regulation CAPN8 CA2 24961530 452828 Positive_regulation CAPN8 CA2 24963283 842475 Positive_regulation CAPN8 CA2 25079291 620424 Positive_regulation CAPN8 CA2 25177270 871055 Positive_regulation CAPN8 CA2 25206508 2004905 Positive_regulation CAPN8 CA2 25309327 871484 Positive_regulation CAPN8 CA2 25341622 5416 Positive_regulation CAPN8 CA2 25352808 966552 Positive_regulation CAPN8 CA2 25364642 452584 Positive_regulation CAPN8 CA2 25489296 860238 Positive_regulation CAPN8 CA2 7595231 1591031 Positive_regulation CAPN8 CA2 9199173 1461115 Positive_regulation CAPN8 CA2 9456328 1466413 Positive_regulation CAPN8 CA2 PMC2063798 1474395 Positive_regulation CAPN8 CA2 PMC2246544 1475865 Positive_regulation CAPN8 CA2 PMC4055958 2247338 Positive_regulation CAPN8 CA3 18706097 291371 Positive_regulation CAPN8 CALB1 24963283 842476 Positive_regulation CAPN8 CAPN1 25110686 196239 Positive_regulation CAPN8 CAPN2 16433929 298630 Positive_regulation CAPN8 CAPN2 21368866 550690 Positive_regulation CAPN8 CAPN2 21368866 550747 Positive_regulation CAPN8 CAPN2 23977256 2839473 Positive_regulation CAPN8 CAPN2 25110686 196240 Positive_regulation CAPN8 CAPNS1 19734909 1960749 Positive_regulation CAPN8 CAPNS1 21368866 550691 Positive_regulation CAPN8 CAPNS1 21368866 550748 Positive_regulation CAPN8 CAPNS1 23977256 2839474 Positive_regulation CAPN8 CAPNS1 25110686 196241 Positive_regulation CAPN8 CASP1 15210727 1309648 Positive_regulation CAPN8 CASP1 9314540 1463698 Positive_regulation CAPN8 CASP10 15210727 1309649 Positive_regulation CAPN8 CASP10 9314540 1463699 Positive_regulation CAPN8 CASP12 15210727 1309659 Positive_regulation CAPN8 CASP12 22252275 1230166 Positive_regulation CAPN8 CASP12 9314540 1463709 Positive_regulation CAPN8 CASP14 15210727 1309650 Positive_regulation CAPN8 CASP14 9314540 1463700 Positive_regulation CAPN8 CASP16 15210727 1309660 Positive_regulation CAPN8 CASP16 9314540 1463710 Positive_regulation CAPN8 CASP2 15210727 1309651 Positive_regulation CAPN8 CASP2 9314540 1463701 Positive_regulation CAPN8 CASP3 15210727 1309652 Positive_regulation CAPN8 CASP3 23425388 275416 Positive_regulation CAPN8 CASP3 23425388 275417 Positive_regulation CAPN8 CASP3 23425388 275662 Positive_regulation CAPN8 CASP3 23425388 275769 Positive_regulation CAPN8 CASP3 9314540 1463702 Positive_regulation CAPN8 CASP4 15210727 1309653 Positive_regulation CAPN8 CASP4 9314540 1463703 Positive_regulation CAPN8 CASP5 15210727 1309654 Positive_regulation CAPN8 CASP5 9314540 1463704 Positive_regulation CAPN8 CASP6 15210727 1309655 Positive_regulation CAPN8 CASP6 9314540 1463705 Positive_regulation CAPN8 CASP7 15210727 1309656 Positive_regulation CAPN8 CASP7 9314540 1463706 Positive_regulation CAPN8 CASP8 15210727 1309657 Positive_regulation CAPN8 CASP8 9314540 1463707 Positive_regulation CAPN8 CASP9 15210727 1309658 Positive_regulation CAPN8 CASP9 22252275 1230165 Positive_regulation CAPN8 CASP9 9314540 1463708 Positive_regulation CAPN8 CAST 18710920 1354880 Positive_regulation CAPN8 CAST 19545424 1625441 Positive_regulation CAPN8 CAST 20233404 659467 Positive_regulation CAPN8 CAST 21765948 2536570 Positive_regulation CAPN8 CAST 22615919 2644294 Positive_regulation CAPN8 CAST 22745213 90588 Positive_regulation CAPN8 CAST 23374507 1728277 Positive_regulation CAPN8 CAST 23425388 275828 Positive_regulation CAPN8 CAST 23507938 588658 Positive_regulation CAPN8 CAST 23507938 588659 Positive_regulation CAPN8 CAST 9566966 1467149 Positive_regulation CAPN8 CAST 9566966 1467261 Positive_regulation CAPN8 CCND1 24999379 2229483 Positive_regulation CAPN8 CCND3 24999379 2229484 Positive_regulation CAPN8 CCNG1 24736629 2953402 Positive_regulation CAPN8 CDC25A 24999379 2229485 Positive_regulation CAPN8 CDK5 19151707 1922099 Positive_regulation CAPN8 CDK5 21902831 3160609 Positive_regulation CAPN8 CPA1 21516125 2139184 Positive_regulation CAPN8 CPA1 21516125 2139216 Positive_regulation CAPN8 CPA1 21516125 2139297 Positive_regulation CAPN8 CRK 21863137 933532 Positive_regulation CAPN8 CSF2 24067145 1900035 Positive_regulation CAPN8 CTSD 18299403 1550023 Positive_regulation CAPN8 CYCS 23865001 3092016 Positive_regulation CAPN8 DDX20 22607171 150485 Positive_regulation CAPN8 EGF 10402474 1248187 Positive_regulation CAPN8 EGF 10402474 1248188 Positive_regulation CAPN8 EGF 10402474 1248189 Positive_regulation CAPN8 EGF 10402474 1248395 Positive_regulation CAPN8 EGF 10402474 1248512 Positive_regulation CAPN8 EGF 10402474 1248538 Positive_regulation CAPN8 EGF 10402474 1248539 Positive_regulation CAPN8 EGF 10402474 1248585 Positive_regulation CAPN8 EGF 10402474 1248609 Positive_regulation CAPN8 EGF 10402474 1248610 Positive_regulation CAPN8 EGF 10402474 1248627 Positive_regulation CAPN8 EGF 10402474 1248655 Positive_regulation CAPN8 EGF 10402474 1248669 Positive_regulation CAPN8 EGF 12782716 1527541 Positive_regulation CAPN8 EGF 18332219 1350004 Positive_regulation CAPN8 EGF 23565252 2777478 Positive_regulation CAPN8 EGFR 10402474 1248190 Positive_regulation CAPN8 EGFR 10402474 1248396 Positive_regulation CAPN8 EPHB2 20937704 1560900 Positive_regulation CAPN8 EPHB2 21048967 2480308 Positive_regulation CAPN8 EPHB2 24586666 2926118 Positive_regulation CAPN8 FERMT3 23311633 409930 Positive_regulation CAPN8 FLNA 20937704 1560745 Positive_regulation CAPN8 GEMIN2 22607171 150477 Positive_regulation CAPN8 GEMIN4 22607171 150481 Positive_regulation CAPN8 GEMIN5 22607171 150482 Positive_regulation CAPN8 GEMIN6 22607171 150483 Positive_regulation CAPN8 GEMIN7 22607171 150484 Positive_regulation CAPN8 GZMB 9314540 1463711 Positive_regulation CAPN8 HSP90AA1 25575026 3037352 Positive_regulation CAPN8 IL1A 23395675 1040863 Positive_regulation CAPN8 IL1A 24022484 1208130 Positive_regulation CAPN8 KANK2 22407449 87219 Positive_regulation CAPN8 MAPK1 20937704 1560901 Positive_regulation CAPN8 MAPK1 25079291 620426 Positive_regulation CAPN8 MAPK1 25341622 5554 Positive_regulation CAPN8 MAPK10 20937704 1560902 Positive_regulation CAPN8 MAPK10 25079291 620427 Positive_regulation CAPN8 MAPK10 25341622 5555 Positive_regulation CAPN8 MAPK11 20937704 1560903 Positive_regulation CAPN8 MAPK11 25079291 620428 Positive_regulation CAPN8 MAPK11 25341622 5556 Positive_regulation CAPN8 MAPK12 20937704 1560904 Positive_regulation CAPN8 MAPK12 25079291 620429 Positive_regulation CAPN8 MAPK12 25341622 5557 Positive_regulation CAPN8 MAPK13 20937704 1560905 Positive_regulation CAPN8 MAPK13 25079291 620430 Positive_regulation CAPN8 MAPK13 25341622 5558 Positive_regulation CAPN8 MAPK14 20937704 1560906 Positive_regulation CAPN8 MAPK14 25079291 620431 Positive_regulation CAPN8 MAPK14 25341622 5559 Positive_regulation CAPN8 MAPK15 20937704 1560899 Positive_regulation CAPN8 MAPK15 25079291 620425 Positive_regulation CAPN8 MAPK15 25341622 5553 Positive_regulation CAPN8 MAPK3 20937704 1560907 Positive_regulation CAPN8 MAPK3 25079291 620432 Positive_regulation CAPN8 MAPK3 25206840 2006106 Positive_regulation CAPN8 MAPK3 25341622 5560 Positive_regulation CAPN8 MAPK4 20937704 1560908 Positive_regulation CAPN8 MAPK4 25079291 620433 Positive_regulation CAPN8 MAPK4 25341622 5561 Positive_regulation CAPN8 MAPK6 20937704 1560909 Positive_regulation CAPN8 MAPK6 25079291 620434 Positive_regulation CAPN8 MAPK6 25341622 5562 Positive_regulation CAPN8 MAPK7 20937704 1560910 Positive_regulation CAPN8 MAPK7 25079291 620435 Positive_regulation CAPN8 MAPK7 25341622 5563 Positive_regulation CAPN8 MAPK8 20937704 1560911 Positive_regulation CAPN8 MAPK8 25079291 620436 Positive_regulation CAPN8 MAPK8 25341622 5564 Positive_regulation CAPN8 MAPK9 20937704 1560912 Positive_regulation CAPN8 MAPK9 25079291 620437 Positive_regulation CAPN8 MAPK9 25341622 5565 Positive_regulation CAPN8 MBTPS1 22407449 87233 Positive_regulation CAPN8 MBTPS1 22407449 87261 Positive_regulation CAPN8 MCS 22163179 1729348 Positive_regulation CAPN8 MMP14 22407449 87092 Positive_regulation CAPN8 MMP9 24026771 1890395 Positive_regulation CAPN8 MPZ 21318163 2232197 Positive_regulation CAPN8 NISCH 25147502 870838 Positive_regulation CAPN8 PARP1 22405498 1230379 Positive_regulation CAPN8 PDGFB PMC3329082 3086492 Positive_regulation CAPN8 PIN1 19545424 1625396 Positive_regulation CAPN8 PIN1 19545424 1625504 Positive_regulation CAPN8 PRKAA1 25147502 870839 Positive_regulation CAPN8 PRKAA2 25147502 870840 Positive_regulation CAPN8 PRKAB1 25147502 870841 Positive_regulation CAPN8 PRKAB2 25147502 870842 Positive_regulation CAPN8 PRKAG1 25147502 870843 Positive_regulation CAPN8 PRKAG2 25147502 870844 Positive_regulation CAPN8 PTPRC 23936270 2829840 Positive_regulation CAPN8 RAC1 21912722 2223932 Positive_regulation CAPN8 RAC1 PMC2185599 1475287 Positive_regulation CAPN8 RAC2 PMC2185599 1475288 Positive_regulation CAPN8 RAC3 PMC2185599 1475289 Positive_regulation CAPN8 RHO PMC2185599 1475286 Positive_regulation CAPN8 ROCK1 12486114 1290163 Positive_regulation CAPN8 ROCK1 12486114 1290240 Positive_regulation CAPN8 ROCK2 12486114 1290164 Positive_regulation CAPN8 ROCK2 12486114 1290241 Positive_regulation CAPN8 RYR1 19198614 1960569 Positive_regulation CAPN8 SEMA6C 22496897 2617776 Positive_regulation CAPN8 SLC12A5 24567703 868780 Positive_regulation CAPN8 SLC9A1 12486114 1290165 Positive_regulation CAPN8 SMARCA4 24811485 2190890 Positive_regulation CAPN8 SMARCB1 24811485 2190891 Positive_regulation CAPN8 SMARCC1 24811485 2190892 Positive_regulation CAPN8 SMARCC2 24811485 2190893 Positive_regulation CAPN8 SMARCD1 24811485 2190894 Positive_regulation CAPN8 SMARCD2 24811485 2190895 Positive_regulation CAPN8 SMARCE1 24811485 2190896 Positive_regulation CAPN8 SMN2 22607171 150478 Positive_regulation CAPN8 SNRPA 22607171 150479 Positive_regulation CAPN8 SNRPB 22607171 150480 Positive_regulation CAPN8 SRC 12163473 1285579 Positive_regulation CAPN8 STRAP 22607171 150486 Positive_regulation CAPN8 STS 24963283 842340 Positive_regulation CAPN8 STS 24963283 842341 Positive_regulation CAPN8 STS 24963283 842385 Positive_regulation CAPN8 TNF 19266085 1671053 Positive_regulation CAPN8 TNF 19266085 1671067 Positive_regulation CAPN8 TNF 22451727 1713297 Positive_regulation CAPN8 TNF 24026771 1890394 Positive_regulation CAPN8 TRPM7 21152086 2486206 Positive_regulation CAPN8 TTN 22496611 1223899 Positive_regulation CAPN8 UGCG 22536436 2622476 Positive_regulation CAPN8 VEGFA 21049044 2480529 Positive_regulation CAPN8 VEGFA 21049044 2480543 Positive_regulation CAPN8 VEGFA 24886224 511573 Positive_regulation CAPN9 CCND1 24999379 2229486 Positive_regulation CAPN9 EPHB2 20937704 1560914 Positive_regulation CAPN9 EPHB2 21048967 2480309 Positive_regulation CAPN9 EPHB2 24586666 2926119 Positive_regulation CAPN9 SMN2 22607171 150488 Positive_regulation CAPN9 TNF 19266085 1671054 Positive_regulation CAPN9 TNF 19266085 1671068 Positive_regulation CAPN9 TNF 22451727 1713298 Positive_regulation CAPN9 TNF 24026771 1890396 Positive_regulation CAPNS1 EPHB2 20847951 1672449 Positive_regulation CAPNS1 EPHB2 22310287 2146240 Positive_regulation CAPNS1 EPHB2 24611062 880333 Positive_regulation CAPZA1 IFI27 22918948 1806764 Positive_regulation CAPZA1 IFI27 22918948 1806843 Positive_regulation CAPZA1 IFI27 22918948 1806844 Positive_regulation CAPZA1 IFI27 22918948 1806874 Positive_regulation CAPZB IFI27 22918948 1806766 Positive_regulation CAPZB IFI27 22918948 1806847 Positive_regulation CAPZB IFI27 22918948 1806848 Positive_regulation CAPZB IFI27 22918948 1806876 Positive_regulation CARD11 TLR7 22303480 2594875 Positive_regulation CASC3 EPHB2 25375375 578928 Positive_regulation CASP1 AXIN2 10496353 415379 Positive_regulation CASP1 CAPN8 15210727 1309684 Positive_regulation CASP1 CAPN8 22281016 1660845 Positive_regulation CASP1 CAPN8 9314540 1463736 Positive_regulation CASP1 CLDN10 22361748 554229 Positive_regulation CASP1 EPHB2 15266324 424674 Positive_regulation CASP1 EPHB2 21037797 2301652 Positive_regulation CASP1 EPHB2 23018309 653345 Positive_regulation CASP1 EPHB2 25013376 1063070 Positive_regulation CASP1 EPHB2 25606044 746813 Positive_regulation CASP1 FAS 10727454 1514576 Positive_regulation CASP1 FAS 10727463 1514837 Positive_regulation CASP1 FAS 11121439 1265813 Positive_regulation CASP1 FAS 11696559 1275977 Positive_regulation CASP1 FAS 11806838 3103616 Positive_regulation CASP1 FAS 12163562 1524366 Positive_regulation CASP1 FAS 12163562 1524462 Positive_regulation CASP1 FAS 12163562 1524493 Positive_regulation CASP1 FAS 14612908 423765 Positive_regulation CASP1 FAS 14738570 277395 Positive_regulation CASP1 FAS 15857508 365169 Positive_regulation CASP1 FAS 16365167 1326344 Positive_regulation CASP1 FAS 17295922 1651100 Positive_regulation CASP1 FAS 19876397 2429969 Positive_regulation CASP1 FAS 21083888 2231188 Positive_regulation CASP1 FAS 21212468 28923 Positive_regulation CASP1 FAS 21477291 527191 Positive_regulation CASP1 FAS 21569413 1723605 Positive_regulation CASP1 FAS 21625644 2525256 Positive_regulation CASP1 FAS 21629700 2525594 Positive_regulation CASP1 FAS 22084408 1566094 Positive_regulation CASP1 FAS 22859258 1086639 Positive_regulation CASP1 FAS 22876188 3058776 Positive_regulation CASP1 FAS 22942738 1097152 Positive_regulation CASP1 FAS 23029562 2698821 Positive_regulation CASP1 FAS 23618909 561685 Positive_regulation CASP1 FAS 23633472 2183097 Positive_regulation CASP1 FAS 23787996 548437 Positive_regulation CASP1 FAS 23935974 2828796 Positive_regulation CASP1 FAS 24157880 568613 Positive_regulation CASP1 FAS 24716143 1694447 Positive_regulation CASP1 FAS 25548754 219487 Positive_regulation CASP1 FAS 25594018 2173710 Positive_regulation CASP1 FAS 9730893 1603537 Positive_regulation CASP1 FAS 9730899 1603735 Positive_regulation CASP1 FAS 9730899 1603748 Positive_regulation CASP1 FAS 9730899 1603788 Positive_regulation CASP1 IFI27 21738161 1961552 Positive_regulation CASP1 IL1B 24701565 188181 Positive_regulation CASP1 MAP2K6 15266324 424680 Positive_regulation CASP1 MIP 21347304 2503542 Positive_regulation CASP1 MIP 25232720 2372941 Positive_regulation CASP1 MMP28 19547714 1671126 Positive_regulation CASP1 MMP28 20416058 1854148 Positive_regulation CASP1 MMP28 25250578 3009331 Positive_regulation CASP1 MMP28 25250578 3009617 Positive_regulation CASP1 MMP7 19547714 1671141 Positive_regulation CASP1 MMP7 20416058 1854163 Positive_regulation CASP1 MMP7 25250578 3009346 Positive_regulation CASP1 MMP7 25250578 3009632 Positive_regulation CASP1 SPHK1 24572701 652050 Positive_regulation CASP1 TLR7 20041168 3046104 Positive_regulation CASP1 TLR7 21533069 3051505 Positive_regulation CASP1 TLR7 22723924 2655085 Positive_regulation CASP1 TLR7 23762026 3061971 Positive_regulation CASP1 TNF 10727454 1514575 Positive_regulation CASP1 TNF 10839812 1515678 Positive_regulation CASP1 TNF 11381085 1270305 Positive_regulation CASP1 TNF 18625845 1353878 Positive_regulation CASP1 TNF 19440308 2416493 Positive_regulation CASP1 TNF 19440308 2416494 Positive_regulation CASP1 TNF 19440308 2416495 Positive_regulation CASP1 TNF 19440308 2416496 Positive_regulation CASP1 TNF 19440308 2416571 Positive_regulation CASP1 TNF 19440308 2416572 Positive_regulation CASP1 TNF 19440308 2416573 Positive_regulation CASP1 TNF 19440308 2416619 Positive_regulation CASP1 TNF 19440308 2416620 Positive_regulation CASP1 TNF 19440308 2416658 Positive_regulation CASP1 TNF 19440308 2416673 Positive_regulation CASP1 TNF 19440308 2416688 Positive_regulation CASP1 TNF 19440308 2416703 Positive_regulation CASP1 TNF 19440308 2416742 Positive_regulation CASP1 TNF 19440308 2416768 Positive_regulation CASP1 TNF 20200974 1237328 Positive_regulation CASP1 TNF 22036896 2176703 Positive_regulation CASP1 TNF 22089168 553459 Positive_regulation CASP1 TNF 22536153 3056415 Positive_regulation CASP1 TNF 22540228 1662221 Positive_regulation CASP1 TNF 22540228 1662236 Positive_regulation CASP1 TNF 22661946 951849 Positive_regulation CASP1 TNF 22864384 1727521 Positive_regulation CASP1 TNF 23264463 1810449 Positive_regulation CASP1 TNF 23383347 2750500 Positive_regulation CASP1 TNF 23386613 1206366 Positive_regulation CASP1 TNF 23659427 509808 Positive_regulation CASP1 TNF 23816559 625750 Positive_regulation CASP1 TNF 23940760 2832263 Positive_regulation CASP1 TNF 23940760 2832264 Positive_regulation CASP1 TNF 23940760 2832265 Positive_regulation CASP1 TNF 23940760 2832285 Positive_regulation CASP1 TNF 23940760 2832311 Positive_regulation CASP1 TNF 24028654 622238 Positive_regulation CASP1 TNF 24028654 622264 Positive_regulation CASP1 TNF 24762050 132295 Positive_regulation CASP1 TNF 24762050 132296 Positive_regulation CASP1 TNF 24762050 132297 Positive_regulation CASP1 TNF 24762050 132298 Positive_regulation CASP1 TNF 24762050 132299 Positive_regulation CASP1 TNF 24762050 132300 Positive_regulation CASP1 TNF 24762050 132310 Positive_regulation CASP1 TNF 24762050 132311 Positive_regulation CASP1 TNF 24762050 132314 Positive_regulation CASP1 TNF 24762050 132315 Positive_regulation CASP1 TNF 24762050 132318 Positive_regulation CASP1 TNF 24762050 132319 Positive_regulation CASP1 TNF 24762050 132323 Positive_regulation CASP1 TNF 24762050 132324 Positive_regulation CASP1 TNF 24762050 132325 Positive_regulation CASP1 TNF 24795644 964996 Positive_regulation CASP1 TNF 25285524 3012403 Positive_regulation CASP1 TNF 9565639 1602729 Positive_regulation CASP1 TNFSF10 19421137 2125089 Positive_regulation CASP1 TNFSF10 19547714 1671408 Positive_regulation CASP1 TNFSF10 19549337 1851016 Positive_regulation CASP1 TNFSF10 19820719 8251 Positive_regulation CASP1 TNFSF10 20442774 2448913 Positive_regulation CASP1 TNFSF10 21368859 550495 Positive_regulation CASP1 TNFSF10 21513580 1861720 Positive_regulation CASP1 TNFSF10 21513580 1861786 Positive_regulation CASP1 TNFSF10 21513580 1861829 Positive_regulation CASP1 TNFSF10 21513580 1861894 Positive_regulation CASP1 TNFSF10 21513580 1861908 Positive_regulation CASP1 TNFSF10 21586138 1862017 Positive_regulation CASP1 TNFSF10 21586138 1862018 Positive_regulation CASP1 TNFSF10 21801359 260638 Positive_regulation CASP1 TNFSF10 21899742 1863322 Positive_regulation CASP1 TNFSF10 22048166 553405 Positive_regulation CASP1 TNFSF10 22174792 2582006 Positive_regulation CASP1 TNFSF10 22213832 1882508 Positive_regulation CASP1 TNFSF10 22619505 1136916 Positive_regulation CASP1 TNFSF10 22662193 2647179 Positive_regulation CASP1 TNFSF10 22860037 2671191 Positive_regulation CASP1 TNFSF10 22876188 3058777 Positive_regulation CASP1 TNFSF10 23348585 559126 Positive_regulation CASP1 TNFSF10 23348588 559145 Positive_regulation CASP1 TNFSF10 23517112 268056 Positive_regulation CASP1 TNFSF10 23818254 781068 Positive_regulation CASP1 TNFSF10 24009855 203891 Positive_regulation CASP1 TNFSF10 24147007 2869106 Positive_regulation CASP1 TNFSF10 24147007 2869128 Positive_regulation CASP1 TNFSF10 24147007 2869144 Positive_regulation CASP1 TNFSF10 24147007 2869160 Positive_regulation CASP1 TNFSF10 24147007 2869182 Positive_regulation CASP1 TNFSF10 24147007 2869195 Positive_regulation CASP1 TNFSF10 24525736 572098 Positive_regulation CASP1 TNFSF10 24618889 2933407 Positive_regulation CASP1 TNFSF10 24648844 1070651 Positive_regulation CASP1 TNFSF10 24690311 272585 Positive_regulation CASP1 TNFSF10 24745479 474626 Positive_regulation CASP1 TNFSF10 24745479 474663 Positive_regulation CASP1 TNFSF10 24745479 474740 Positive_regulation CASP1 TNFSF10 24745479 474741 Positive_regulation CASP1 TNFSF10 24745479 474742 Positive_regulation CASP1 TNFSF10 24745479 474853 Positive_regulation CASP1 TNFSF10 24745479 474890 Positive_regulation CASP1 TNFSF10 25321472 578292 Positive_regulation CASP1 TP63 23703390 561950 Positive_regulation CASP1 TP63 23703390 561956 Positive_regulation CASP1 TP63 23703390 561957 Positive_regulation CASP10 ARSA 25061812 2992433 Positive_regulation CASP10 ARSA 25061812 2992541 Positive_regulation CASP10 CAPN8 15210727 1309698 Positive_regulation CASP10 CAPN8 22281016 1660859 Positive_regulation CASP10 CAPN8 9314540 1463750 Positive_regulation CASP10 CLDN10 22361748 554254 Positive_regulation CASP10 EPHB2 15266324 424682 Positive_regulation CASP10 EPHB2 21037797 2301653 Positive_regulation CASP10 EPHB2 23018309 653346 Positive_regulation CASP10 EPHB2 25013376 1063071 Positive_regulation CASP10 EPHB2 25606044 746815 Positive_regulation CASP10 FAS 10727454 1514578 Positive_regulation CASP10 FAS 11121439 1265814 Positive_regulation CASP10 FAS 11696559 1275979 Positive_regulation CASP10 FAS 12163562 1524367 Positive_regulation CASP10 FAS 12163562 1524463 Positive_regulation CASP10 FAS 12163562 1524494 Positive_regulation CASP10 FAS 14612908 423766 Positive_regulation CASP10 FAS 15857508 365170 Positive_regulation CASP10 FAS 16365167 1326345 Positive_regulation CASP10 FAS 17295922 1651102 Positive_regulation CASP10 FAS 21083888 2231191 Positive_regulation CASP10 FAS 21212468 28924 Positive_regulation CASP10 FAS 21477291 527192 Positive_regulation CASP10 FAS 21569413 1723607 Positive_regulation CASP10 FAS 21625644 2525257 Positive_regulation CASP10 FAS 21629700 2525595 Positive_regulation CASP10 FAS 22084408 1566096 Positive_regulation CASP10 FAS 22859258 1086640 Positive_regulation CASP10 FAS 22876188 3058778 Positive_regulation CASP10 FAS 22942738 1097154 Positive_regulation CASP10 FAS 23029562 2698822 Positive_regulation CASP10 FAS 23191987 357296 Positive_regulation CASP10 FAS 23618909 561686 Positive_regulation CASP10 FAS 23633472 2183098 Positive_regulation CASP10 FAS 23787996 548438 Positive_regulation CASP10 FAS 24157880 568614 Positive_regulation CASP10 FAS 24716143 1694449 Positive_regulation CASP10 FAS 24949464 192761 Positive_regulation CASP10 FAS 25548754 219488 Positive_regulation CASP10 FAS 25594018 2173711 Positive_regulation CASP10 FAS 9730893 1603538 Positive_regulation CASP10 FAS 9730899 1603736 Positive_regulation CASP10 FAS 9730899 1603749 Positive_regulation CASP10 FAS 9730899 1603789 Positive_regulation CASP10 MAP2K6 15266324 424688 Positive_regulation CASP10 MIP 21347304 2503543 Positive_regulation CASP10 MMP28 19547714 1671148 Positive_regulation CASP10 MMP28 20416058 1854171 Positive_regulation CASP10 MMP28 25250578 3009353 Positive_regulation CASP10 MMP28 25250578 3009639 Positive_regulation CASP10 MMP7 19547714 1671163 Positive_regulation CASP10 MMP7 20416058 1854186 Positive_regulation CASP10 MMP7 25250578 3009368 Positive_regulation CASP10 MMP7 25250578 3009654 Positive_regulation CASP10 SPHK1 24572701 652051 Positive_regulation CASP10 TLR7 23762026 3061983 Positive_regulation CASP10 TNF 10727454 1514577 Positive_regulation CASP10 TNF 10839812 1515679 Positive_regulation CASP10 TNF 11381085 1270306 Positive_regulation CASP10 TNF 18625845 1353879 Positive_regulation CASP10 TNF 19440308 2416497 Positive_regulation CASP10 TNF 19440308 2416498 Positive_regulation CASP10 TNF 19440308 2416499 Positive_regulation CASP10 TNF 19440308 2416500 Positive_regulation CASP10 TNF 19440308 2416574 Positive_regulation CASP10 TNF 19440308 2416575 Positive_regulation CASP10 TNF 19440308 2416576 Positive_regulation CASP10 TNF 19440308 2416621 Positive_regulation CASP10 TNF 19440308 2416622 Positive_regulation CASP10 TNF 19440308 2416659 Positive_regulation CASP10 TNF 19440308 2416674 Positive_regulation CASP10 TNF 19440308 2416689 Positive_regulation CASP10 TNF 19440308 2416704 Positive_regulation CASP10 TNF 19440308 2416743 Positive_regulation CASP10 TNF 19440308 2416769 Positive_regulation CASP10 TNF 20200974 1237329 Positive_regulation CASP10 TNF 22036896 2176704 Positive_regulation CASP10 TNF 22089168 553460 Positive_regulation CASP10 TNF 22540228 1662222 Positive_regulation CASP10 TNF 22540228 1662237 Positive_regulation CASP10 TNF 22864384 1727522 Positive_regulation CASP10 TNF 23191987 357295 Positive_regulation CASP10 TNF 23264463 1810450 Positive_regulation CASP10 TNF 23386613 1206367 Positive_regulation CASP10 TNF 23659427 509809 Positive_regulation CASP10 TNF 23816559 625751 Positive_regulation CASP10 TNF 24028654 622239 Positive_regulation CASP10 TNF 24028654 622265 Positive_regulation CASP10 TNF 24795644 964997 Positive_regulation CASP10 TNF 24949464 192760 Positive_regulation CASP10 TNF 25285524 3012404 Positive_regulation CASP10 TNF 9565639 1602730 Positive_regulation CASP10 TNFSF10 17718901 1645694 Positive_regulation CASP10 TNFSF10 19421137 2125090 Positive_regulation CASP10 TNFSF10 19547714 1671409 Positive_regulation CASP10 TNFSF10 19549337 1851017 Positive_regulation CASP10 TNFSF10 19820719 8252 Positive_regulation CASP10 TNFSF10 20442774 2448914 Positive_regulation CASP10 TNFSF10 21368859 550503 Positive_regulation CASP10 TNFSF10 21513580 1861722 Positive_regulation CASP10 TNFSF10 21513580 1861788 Positive_regulation CASP10 TNFSF10 21513580 1861832 Positive_regulation CASP10 TNFSF10 21513580 1861895 Positive_regulation CASP10 TNFSF10 21513580 1861911 Positive_regulation CASP10 TNFSF10 21586138 1862020 Positive_regulation CASP10 TNFSF10 21586138 1862021 Positive_regulation CASP10 TNFSF10 21801359 260639 Positive_regulation CASP10 TNFSF10 21899742 1863324 Positive_regulation CASP10 TNFSF10 22048166 553406 Positive_regulation CASP10 TNFSF10 22174792 2582008 Positive_regulation CASP10 TNFSF10 22213832 1882509 Positive_regulation CASP10 TNFSF10 22461781 924822 Positive_regulation CASP10 TNFSF10 22619505 1136918 Positive_regulation CASP10 TNFSF10 22662193 2647180 Positive_regulation CASP10 TNFSF10 22860037 2671192 Positive_regulation CASP10 TNFSF10 22876188 3058779 Positive_regulation CASP10 TNFSF10 23191987 357297 Positive_regulation CASP10 TNFSF10 23348585 559127 Positive_regulation CASP10 TNFSF10 23348588 559146 Positive_regulation CASP10 TNFSF10 23517112 268057 Positive_regulation CASP10 TNFSF10 23533482 817810 Positive_regulation CASP10 TNFSF10 23818254 781069 Positive_regulation CASP10 TNFSF10 24009855 203892 Positive_regulation CASP10 TNFSF10 24147007 2869107 Positive_regulation CASP10 TNFSF10 24147007 2869129 Positive_regulation CASP10 TNFSF10 24147007 2869145 Positive_regulation CASP10 TNFSF10 24147007 2869161 Positive_regulation CASP10 TNFSF10 24147007 2869183 Positive_regulation CASP10 TNFSF10 24147007 2869196 Positive_regulation CASP10 TNFSF10 24525736 572099 Positive_regulation CASP10 TNFSF10 24618889 2933408 Positive_regulation CASP10 TNFSF10 24648844 1070652 Positive_regulation CASP10 TNFSF10 24690311 272586 Positive_regulation CASP10 TNFSF10 24745479 474627 Positive_regulation CASP10 TNFSF10 24745479 474664 Positive_regulation CASP10 TNFSF10 24745479 474743 Positive_regulation CASP10 TNFSF10 24745479 474744 Positive_regulation CASP10 TNFSF10 24745479 474745 Positive_regulation CASP10 TNFSF10 24745479 474854 Positive_regulation CASP10 TNFSF10 24745479 474891 Positive_regulation CASP10 TNFSF10 25321472 578293 Positive_regulation CASP12 CAPN8 10953012 1262113 Positive_regulation CASP12 CAPN8 10953012 1262127 Positive_regulation CASP12 CAPN8 10953012 1262141 Positive_regulation CASP12 CAPN8 10953012 1262155 Positive_regulation CASP12 CAPN8 10953012 1262225 Positive_regulation CASP12 CAPN8 15210727 1309864 Positive_regulation CASP12 CAPN8 21633391 552261 Positive_regulation CASP12 CAPN8 22252275 1230198 Positive_regulation CASP12 CAPN8 22281016 1660999 Positive_regulation CASP12 CAPN8 22613960 1140890 Positive_regulation CASP12 CAPN8 23682710 89848 Positive_regulation CASP12 CAPN8 24106522 823083 Positive_regulation CASP12 CAPN8 25121098 196576 Positive_regulation CASP12 CAPN8 9314540 1463918 Positive_regulation CASP12 CLDN10 22361748 554518 Positive_regulation CASP12 EPHB2 15266324 424762 Positive_regulation CASP12 EPHB2 21037797 2301663 Positive_regulation CASP12 EPHB2 23018309 653356 Positive_regulation CASP12 EPHB2 25013376 1063081 Positive_regulation CASP12 EPHB2 25606044 746835 Positive_regulation CASP12 FAS 10727454 1514598 Positive_regulation CASP12 FAS 11121439 1265824 Positive_regulation CASP12 FAS 11696559 1275999 Positive_regulation CASP12 FAS 12163562 1524380 Positive_regulation CASP12 FAS 12163562 1524473 Positive_regulation CASP12 FAS 12163562 1524504 Positive_regulation CASP12 FAS 14612908 423776 Positive_regulation CASP12 FAS 15857508 365180 Positive_regulation CASP12 FAS 16365167 1326355 Positive_regulation CASP12 FAS 17295922 1651122 Positive_regulation CASP12 FAS 21083888 2231221 Positive_regulation CASP12 FAS 21212468 28934 Positive_regulation CASP12 FAS 21477291 527202 Positive_regulation CASP12 FAS 21569413 1723627 Positive_regulation CASP12 FAS 21625644 2525267 Positive_regulation CASP12 FAS 21629700 2525605 Positive_regulation CASP12 FAS 22084408 1566116 Positive_regulation CASP12 FAS 22859258 1086650 Positive_regulation CASP12 FAS 22876188 3058798 Positive_regulation CASP12 FAS 22942738 1097174 Positive_regulation CASP12 FAS 23029562 2698833 Positive_regulation CASP12 FAS 23618909 561696 Positive_regulation CASP12 FAS 23633472 2183108 Positive_regulation CASP12 FAS 23787996 548448 Positive_regulation CASP12 FAS 24157880 568624 Positive_regulation CASP12 FAS 24716143 1694469 Positive_regulation CASP12 FAS 25548754 219498 Positive_regulation CASP12 FAS 25594018 2173721 Positive_regulation CASP12 FAS 9730893 1603548 Positive_regulation CASP12 FAS 9730899 1603746 Positive_regulation CASP12 FAS 9730899 1603773 Positive_regulation CASP12 FAS 9730899 1603799 Positive_regulation CASP12 MAP2K6 15266324 424768 Positive_regulation CASP12 MIP 21347304 2503553 Positive_regulation CASP12 MMP28 19547714 1671368 Positive_regulation CASP12 MMP28 20416058 1854401 Positive_regulation CASP12 MMP28 25250578 3009573 Positive_regulation CASP12 MMP28 25250578 3009859 Positive_regulation CASP12 MMP7 19547714 1671383 Positive_regulation CASP12 MMP7 20416058 1854416 Positive_regulation CASP12 MMP7 25250578 3009588 Positive_regulation CASP12 MMP7 25250578 3009874 Positive_regulation CASP12 SPHK1 24572701 652061 Positive_regulation CASP12 TLR7 23762026 3062093 Positive_regulation CASP12 TNF 10727454 1514597 Positive_regulation CASP12 TNF 10839812 1515689 Positive_regulation CASP12 TNF 11381085 1270316 Positive_regulation CASP12 TNF 18625845 1353889 Positive_regulation CASP12 TNF 19440308 2416537 Positive_regulation CASP12 TNF 19440308 2416538 Positive_regulation CASP12 TNF 19440308 2416539 Positive_regulation CASP12 TNF 19440308 2416540 Positive_regulation CASP12 TNF 19440308 2416602 Positive_regulation CASP12 TNF 19440308 2416603 Positive_regulation CASP12 TNF 19440308 2416641 Positive_regulation CASP12 TNF 19440308 2416642 Positive_regulation CASP12 TNF 19440308 2416669 Positive_regulation CASP12 TNF 19440308 2416684 Positive_regulation CASP12 TNF 19440308 2416699 Positive_regulation CASP12 TNF 19440308 2416714 Positive_regulation CASP12 TNF 19440308 2416753 Positive_regulation CASP12 TNF 19440308 2416779 Positive_regulation CASP12 TNF 20200974 1237341 Positive_regulation CASP12 TNF 22036896 2176714 Positive_regulation CASP12 TNF 22089168 553470 Positive_regulation CASP12 TNF 22540228 1662234 Positive_regulation CASP12 TNF 22540228 1662247 Positive_regulation CASP12 TNF 22864384 1727532 Positive_regulation CASP12 TNF 23264463 1810460 Positive_regulation CASP12 TNF 23386613 1206377 Positive_regulation CASP12 TNF 23659427 509819 Positive_regulation CASP12 TNF 23696882 2795768 Positive_regulation CASP12 TNF 23816559 625761 Positive_regulation CASP12 TNF 24028654 622249 Positive_regulation CASP12 TNF 24028654 622275 Positive_regulation CASP12 TNF 24795644 965008 Positive_regulation CASP12 TNF 24920883 743109 Positive_regulation CASP12 TNF 25285524 3012414 Positive_regulation CASP12 TNF 25470819 3032056 Positive_regulation CASP12 TNF 25470819 3032061 Positive_regulation CASP12 TNF 9565639 1602740 Positive_regulation CASP12 TNFSF10 19421137 2125100 Positive_regulation CASP12 TNFSF10 19547714 1671420 Positive_regulation CASP12 TNFSF10 19549337 1851027 Positive_regulation CASP12 TNFSF10 19820719 8262 Positive_regulation CASP12 TNFSF10 20442774 2448924 Positive_regulation CASP12 TNFSF10 21368859 550583 Positive_regulation CASP12 TNFSF10 21513580 1861746 Positive_regulation CASP12 TNFSF10 21513580 1861808 Positive_regulation CASP12 TNFSF10 21513580 1861862 Positive_regulation CASP12 TNFSF10 21513580 1861905 Positive_regulation CASP12 TNFSF10 21513580 1861942 Positive_regulation CASP12 TNFSF10 21586138 1862051 Positive_regulation CASP12 TNFSF10 21586138 1862052 Positive_regulation CASP12 TNFSF10 21801359 260649 Positive_regulation CASP12 TNFSF10 21899742 1863344 Positive_regulation CASP12 TNFSF10 22048166 553416 Positive_regulation CASP12 TNFSF10 22174792 2582028 Positive_regulation CASP12 TNFSF10 22213832 1882519 Positive_regulation CASP12 TNFSF10 22613960 1140848 Positive_regulation CASP12 TNFSF10 22613960 1140861 Positive_regulation CASP12 TNFSF10 22619505 1136938 Positive_regulation CASP12 TNFSF10 22662193 2647190 Positive_regulation CASP12 TNFSF10 22860037 2671202 Positive_regulation CASP12 TNFSF10 22876188 3058799 Positive_regulation CASP12 TNFSF10 23348585 559137 Positive_regulation CASP12 TNFSF10 23348588 559162 Positive_regulation CASP12 TNFSF10 23517112 268067 Positive_regulation CASP12 TNFSF10 23818254 781079 Positive_regulation CASP12 TNFSF10 24009855 203902 Positive_regulation CASP12 TNFSF10 24147007 2869117 Positive_regulation CASP12 TNFSF10 24147007 2869139 Positive_regulation CASP12 TNFSF10 24147007 2869156 Positive_regulation CASP12 TNFSF10 24147007 2869171 Positive_regulation CASP12 TNFSF10 24147007 2869193 Positive_regulation CASP12 TNFSF10 24147007 2869206 Positive_regulation CASP12 TNFSF10 24525736 572111 Positive_regulation CASP12 TNFSF10 24618889 2933418 Positive_regulation CASP12 TNFSF10 24648844 1070662 Positive_regulation CASP12 TNFSF10 24690311 272597 Positive_regulation CASP12 TNFSF10 24745479 474659 Positive_regulation CASP12 TNFSF10 24745479 474723 Positive_regulation CASP12 TNFSF10 24745479 474790 Positive_regulation CASP12 TNFSF10 24745479 474791 Positive_regulation CASP12 TNFSF10 24745479 474875 Positive_regulation CASP12 TNFSF10 24745479 474910 Positive_regulation CASP12 TNFSF10 25321472 578329 Positive_regulation CASP14 CAPN8 15210727 1309712 Positive_regulation CASP14 CAPN8 22281016 1660873 Positive_regulation CASP14 CAPN8 9314540 1463764 Positive_regulation CASP14 CLDN10 22361748 554279 Positive_regulation CASP14 EPHB2 15266324 424690 Positive_regulation CASP14 EPHB2 21037797 2301654 Positive_regulation CASP14 EPHB2 23018309 653347 Positive_regulation CASP14 EPHB2 25013376 1063072 Positive_regulation CASP14 EPHB2 25606044 746817 Positive_regulation CASP14 FAS 10727454 1514580 Positive_regulation CASP14 FAS 11121439 1265815 Positive_regulation CASP14 FAS 11696559 1275981 Positive_regulation CASP14 FAS 12163562 1524368 Positive_regulation CASP14 FAS 12163562 1524464 Positive_regulation CASP14 FAS 12163562 1524495 Positive_regulation CASP14 FAS 14612908 423767 Positive_regulation CASP14 FAS 15857508 365171 Positive_regulation CASP14 FAS 16365167 1326346 Positive_regulation CASP14 FAS 17295922 1651104 Positive_regulation CASP14 FAS 21083888 2231194 Positive_regulation CASP14 FAS 21212468 28925 Positive_regulation CASP14 FAS 21477291 527193 Positive_regulation CASP14 FAS 21569413 1723609 Positive_regulation CASP14 FAS 21625644 2525258 Positive_regulation CASP14 FAS 21629700 2525596 Positive_regulation CASP14 FAS 22084408 1566098 Positive_regulation CASP14 FAS 22859258 1086641 Positive_regulation CASP14 FAS 22876188 3058780 Positive_regulation CASP14 FAS 22942738 1097156 Positive_regulation CASP14 FAS 23029562 2698823 Positive_regulation CASP14 FAS 23618909 561687 Positive_regulation CASP14 FAS 23633472 2183099 Positive_regulation CASP14 FAS 23787996 548439 Positive_regulation CASP14 FAS 24157880 568615 Positive_regulation CASP14 FAS 24716143 1694451 Positive_regulation CASP14 FAS 25548754 219489 Positive_regulation CASP14 FAS 25594018 2173712 Positive_regulation CASP14 FAS 9730893 1603539 Positive_regulation CASP14 FAS 9730899 1603737 Positive_regulation CASP14 FAS 9730899 1603750 Positive_regulation CASP14 FAS 9730899 1603790 Positive_regulation CASP14 MAP2K6 15266324 424696 Positive_regulation CASP14 MIP 21347304 2503544 Positive_regulation CASP14 MMP28 19547714 1671170 Positive_regulation CASP14 MMP28 20416058 1854194 Positive_regulation CASP14 MMP28 25250578 3009375 Positive_regulation CASP14 MMP28 25250578 3009661 Positive_regulation CASP14 MMP7 19547714 1671185 Positive_regulation CASP14 MMP7 20416058 1854209 Positive_regulation CASP14 MMP7 25250578 3009390 Positive_regulation CASP14 MMP7 25250578 3009676 Positive_regulation CASP14 SPHK1 24572701 652052 Positive_regulation CASP14 TLR7 23762026 3061993 Positive_regulation CASP14 TNF 10727454 1514579 Positive_regulation CASP14 TNF 10839812 1515680 Positive_regulation CASP14 TNF 11381085 1270307 Positive_regulation CASP14 TNF 18625845 1353880 Positive_regulation CASP14 TNF 19440308 2416501 Positive_regulation CASP14 TNF 19440308 2416502 Positive_regulation CASP14 TNF 19440308 2416503 Positive_regulation CASP14 TNF 19440308 2416504 Positive_regulation CASP14 TNF 19440308 2416577 Positive_regulation CASP14 TNF 19440308 2416578 Positive_regulation CASP14 TNF 19440308 2416579 Positive_regulation CASP14 TNF 19440308 2416623 Positive_regulation CASP14 TNF 19440308 2416624 Positive_regulation CASP14 TNF 19440308 2416660 Positive_regulation CASP14 TNF 19440308 2416675 Positive_regulation CASP14 TNF 19440308 2416690 Positive_regulation CASP14 TNF 19440308 2416705 Positive_regulation CASP14 TNF 19440308 2416744 Positive_regulation CASP14 TNF 19440308 2416770 Positive_regulation CASP14 TNF 20200974 1237330 Positive_regulation CASP14 TNF 22036896 2176705 Positive_regulation CASP14 TNF 22089168 553461 Positive_regulation CASP14 TNF 22540228 1662223 Positive_regulation CASP14 TNF 22540228 1662238 Positive_regulation CASP14 TNF 22864384 1727523 Positive_regulation CASP14 TNF 23264463 1810451 Positive_regulation CASP14 TNF 23386613 1206368 Positive_regulation CASP14 TNF 23659427 509810 Positive_regulation CASP14 TNF 23816559 625752 Positive_regulation CASP14 TNF 24028654 622240 Positive_regulation CASP14 TNF 24028654 622266 Positive_regulation CASP14 TNF 24795644 964998 Positive_regulation CASP14 TNF 25285524 3012405 Positive_regulation CASP14 TNF 9565639 1602731 Positive_regulation CASP14 TNFSF10 19421137 2125091 Positive_regulation CASP14 TNFSF10 19547714 1671410 Positive_regulation CASP14 TNFSF10 19549337 1851018 Positive_regulation CASP14 TNFSF10 19820719 8253 Positive_regulation CASP14 TNFSF10 20442774 2448915 Positive_regulation CASP14 TNFSF10 21368859 550511 Positive_regulation CASP14 TNFSF10 21513580 1861724 Positive_regulation CASP14 TNFSF10 21513580 1861790 Positive_regulation CASP14 TNFSF10 21513580 1861835 Positive_regulation CASP14 TNFSF10 21513580 1861896 Positive_regulation CASP14 TNFSF10 21513580 1861914 Positive_regulation CASP14 TNFSF10 21586138 1862023 Positive_regulation CASP14 TNFSF10 21586138 1862024 Positive_regulation CASP14 TNFSF10 21801359 260640 Positive_regulation CASP14 TNFSF10 21899742 1863326 Positive_regulation CASP14 TNFSF10 22048166 553407 Positive_regulation CASP14 TNFSF10 22174792 2582010 Positive_regulation CASP14 TNFSF10 22213832 1882510 Positive_regulation CASP14 TNFSF10 22619505 1136920 Positive_regulation CASP14 TNFSF10 22662193 2647181 Positive_regulation CASP14 TNFSF10 22860037 2671193 Positive_regulation CASP14 TNFSF10 22876188 3058781 Positive_regulation CASP14 TNFSF10 23348585 559128 Positive_regulation CASP14 TNFSF10 23348588 559147 Positive_regulation CASP14 TNFSF10 23517112 268058 Positive_regulation CASP14 TNFSF10 23818254 781070 Positive_regulation CASP14 TNFSF10 24009855 203893 Positive_regulation CASP14 TNFSF10 24147007 2869108 Positive_regulation CASP14 TNFSF10 24147007 2869130 Positive_regulation CASP14 TNFSF10 24147007 2869146 Positive_regulation CASP14 TNFSF10 24147007 2869162 Positive_regulation CASP14 TNFSF10 24147007 2869184 Positive_regulation CASP14 TNFSF10 24147007 2869197 Positive_regulation CASP14 TNFSF10 24525736 572100 Positive_regulation CASP14 TNFSF10 24618889 2933409 Positive_regulation CASP14 TNFSF10 24648844 1070653 Positive_regulation CASP14 TNFSF10 24690311 272587 Positive_regulation CASP14 TNFSF10 24745479 474628 Positive_regulation CASP14 TNFSF10 24745479 474665 Positive_regulation CASP14 TNFSF10 24745479 474746 Positive_regulation CASP14 TNFSF10 24745479 474747 Positive_regulation CASP14 TNFSF10 24745479 474748 Positive_regulation CASP14 TNFSF10 24745479 474855 Positive_regulation CASP14 TNFSF10 24745479 474892 Positive_regulation CASP14 TNFSF10 25321472 578294 Positive_regulation CASP16 CAPN8 15210727 1309878 Positive_regulation CASP16 CAPN8 22281016 1661013 Positive_regulation CASP16 CAPN8 9314540 1463932 Positive_regulation CASP16 CLDN10 22361748 554790 Positive_regulation CASP16 EPHB2 15266324 424770 Positive_regulation CASP16 EPHB2 21037797 2301664 Positive_regulation CASP16 EPHB2 23018309 653357 Positive_regulation CASP16 EPHB2 25013376 1063082 Positive_regulation CASP16 EPHB2 25606044 746837 Positive_regulation CASP16 FAS 10727454 1514600 Positive_regulation CASP16 FAS 11121439 1265825 Positive_regulation CASP16 FAS 11696559 1276001 Positive_regulation CASP16 FAS 12163562 1524381 Positive_regulation CASP16 FAS 12163562 1524474 Positive_regulation CASP16 FAS 12163562 1524505 Positive_regulation CASP16 FAS 14612908 423778 Positive_regulation CASP16 FAS 15857508 365181 Positive_regulation CASP16 FAS 16365167 1326356 Positive_regulation CASP16 FAS 17295922 1651124 Positive_regulation CASP16 FAS 21083888 2231224 Positive_regulation CASP16 FAS 21212468 28935 Positive_regulation CASP16 FAS 21477291 527203 Positive_regulation CASP16 FAS 21569413 1723629 Positive_regulation CASP16 FAS 21625644 2525268 Positive_regulation CASP16 FAS 21629700 2525606 Positive_regulation CASP16 FAS 22084408 1566118 Positive_regulation CASP16 FAS 22859258 1086651 Positive_regulation CASP16 FAS 22876188 3058800 Positive_regulation CASP16 FAS 22942738 1097176 Positive_regulation CASP16 FAS 23029562 2698834 Positive_regulation CASP16 FAS 23618909 561698 Positive_regulation CASP16 FAS 23633472 2183109 Positive_regulation CASP16 FAS 23787996 548449 Positive_regulation CASP16 FAS 24157880 568625 Positive_regulation CASP16 FAS 24716143 1694471 Positive_regulation CASP16 FAS 25548754 219499 Positive_regulation CASP16 FAS 25594018 2173722 Positive_regulation CASP16 FAS 9730893 1603549 Positive_regulation CASP16 FAS 9730899 1603747 Positive_regulation CASP16 FAS 9730899 1603774 Positive_regulation CASP16 FAS 9730899 1603800 Positive_regulation CASP16 MAP2K6 15266324 424776 Positive_regulation CASP16 MIP 21347304 2503554 Positive_regulation CASP16 MMP28 19547714 1671390 Positive_regulation CASP16 MMP28 20416058 1854424 Positive_regulation CASP16 MMP28 25250578 3009595 Positive_regulation CASP16 MMP28 25250578 3009881 Positive_regulation CASP16 MMP7 19547714 1671405 Positive_regulation CASP16 MMP7 20416058 1854439 Positive_regulation CASP16 MMP7 25250578 3009610 Positive_regulation CASP16 MMP7 25250578 3009896 Positive_regulation CASP16 SPHK1 24572701 652062 Positive_regulation CASP16 TLR7 23762026 3062103 Positive_regulation CASP16 TNF 10727454 1514599 Positive_regulation CASP16 TNF 10839812 1515692 Positive_regulation CASP16 TNF 11381085 1270317 Positive_regulation CASP16 TNF 18625845 1353890 Positive_regulation CASP16 TNF 19440308 2416541 Positive_regulation CASP16 TNF 19440308 2416542 Positive_regulation CASP16 TNF 19440308 2416543 Positive_regulation CASP16 TNF 19440308 2416544 Positive_regulation CASP16 TNF 19440308 2416604 Positive_regulation CASP16 TNF 19440308 2416605 Positive_regulation CASP16 TNF 19440308 2416643 Positive_regulation CASP16 TNF 19440308 2416644 Positive_regulation CASP16 TNF 19440308 2416670 Positive_regulation CASP16 TNF 19440308 2416685 Positive_regulation CASP16 TNF 19440308 2416700 Positive_regulation CASP16 TNF 19440308 2416715 Positive_regulation CASP16 TNF 19440308 2416754 Positive_regulation CASP16 TNF 19440308 2416780 Positive_regulation CASP16 TNF 20200974 1237342 Positive_regulation CASP16 TNF 22036896 2176715 Positive_regulation CASP16 TNF 22089168 553471 Positive_regulation CASP16 TNF 22540228 1662235 Positive_regulation CASP16 TNF 22540228 1662248 Positive_regulation CASP16 TNF 22864384 1727533 Positive_regulation CASP16 TNF 23264463 1810461 Positive_regulation CASP16 TNF 23386613 1206378 Positive_regulation CASP16 TNF 23659427 509820 Positive_regulation CASP16 TNF 23816559 625762 Positive_regulation CASP16 TNF 24028654 622250 Positive_regulation CASP16 TNF 24028654 622276 Positive_regulation CASP16 TNF 24795644 965009 Positive_regulation CASP16 TNF 25285524 3012415 Positive_regulation CASP16 TNF 9565639 1602741 Positive_regulation CASP16 TNFSF10 19421137 2125101 Positive_regulation CASP16 TNFSF10 19547714 1671421 Positive_regulation CASP16 TNFSF10 19549337 1851028 Positive_regulation CASP16 TNFSF10 19820719 8263 Positive_regulation CASP16 TNFSF10 20442774 2448925 Positive_regulation CASP16 TNFSF10 21368859 550593 Positive_regulation CASP16 TNFSF10 21513580 1861748 Positive_regulation CASP16 TNFSF10 21513580 1861810 Positive_regulation CASP16 TNFSF10 21513580 1861865 Positive_regulation CASP16 TNFSF10 21513580 1861906 Positive_regulation CASP16 TNFSF10 21513580 1861945 Positive_regulation CASP16 TNFSF10 21586138 1862054 Positive_regulation CASP16 TNFSF10 21586138 1862055 Positive_regulation CASP16 TNFSF10 21801359 260650 Positive_regulation CASP16 TNFSF10 21899742 1863346 Positive_regulation CASP16 TNFSF10 22048166 553417 Positive_regulation CASP16 TNFSF10 22174792 2582030 Positive_regulation CASP16 TNFSF10 22213832 1882520 Positive_regulation CASP16 TNFSF10 22619505 1136940 Positive_regulation CASP16 TNFSF10 22662193 2647191 Positive_regulation CASP16 TNFSF10 22860037 2671203 Positive_regulation CASP16 TNFSF10 22876188 3058801 Positive_regulation CASP16 TNFSF10 23348585 559138 Positive_regulation CASP16 TNFSF10 23348588 559163 Positive_regulation CASP16 TNFSF10 23517112 268068 Positive_regulation CASP16 TNFSF10 23818254 781080 Positive_regulation CASP16 TNFSF10 24009855 203903 Positive_regulation CASP16 TNFSF10 24147007 2869118 Positive_regulation CASP16 TNFSF10 24147007 2869140 Positive_regulation CASP16 TNFSF10 24147007 2869158 Positive_regulation CASP16 TNFSF10 24147007 2869172 Positive_regulation CASP16 TNFSF10 24147007 2869194 Positive_regulation CASP16 TNFSF10 24147007 2869208 Positive_regulation CASP16 TNFSF10 24525736 572115 Positive_regulation CASP16 TNFSF10 24618889 2933419 Positive_regulation CASP16 TNFSF10 24648844 1070663 Positive_regulation CASP16 TNFSF10 24690311 272598 Positive_regulation CASP16 TNFSF10 24745479 474660 Positive_regulation CASP16 TNFSF10 24745479 474724 Positive_regulation CASP16 TNFSF10 24745479 474792 Positive_regulation CASP16 TNFSF10 24745479 474793 Positive_regulation CASP16 TNFSF10 24745479 474876 Positive_regulation CASP16 TNFSF10 24745479 474911 Positive_regulation CASP16 TNFSF10 25321472 578330 Positive_regulation CASP2 CAPN8 15210727 1309726 Positive_regulation CASP2 CAPN8 22281016 1660887 Positive_regulation CASP2 CAPN8 9314540 1463778 Positive_regulation CASP2 CLDN10 22361748 554304 Positive_regulation CASP2 EPHB2 15266324 424698 Positive_regulation CASP2 EPHB2 21037797 2301655 Positive_regulation CASP2 EPHB2 23018309 653348 Positive_regulation CASP2 EPHB2 25013376 1063073 Positive_regulation CASP2 EPHB2 25606044 746819 Positive_regulation CASP2 FAS 10727454 1514582 Positive_regulation CASP2 FAS 11121439 1265816 Positive_regulation CASP2 FAS 11696559 1275983 Positive_regulation CASP2 FAS 12163562 1524369 Positive_regulation CASP2 FAS 12163562 1524465 Positive_regulation CASP2 FAS 12163562 1524496 Positive_regulation CASP2 FAS 14612908 423768 Positive_regulation CASP2 FAS 15857508 365172 Positive_regulation CASP2 FAS 16365167 1326347 Positive_regulation CASP2 FAS 17295922 1651106 Positive_regulation CASP2 FAS 21083888 2231197 Positive_regulation CASP2 FAS 21212468 28926 Positive_regulation CASP2 FAS 21477291 527194 Positive_regulation CASP2 FAS 21569413 1723611 Positive_regulation CASP2 FAS 21625644 2525259 Positive_regulation CASP2 FAS 21629700 2525597 Positive_regulation CASP2 FAS 22084408 1566100 Positive_regulation CASP2 FAS 22859258 1086642 Positive_regulation CASP2 FAS 22876188 3058782 Positive_regulation CASP2 FAS 22942738 1097158 Positive_regulation CASP2 FAS 23029562 2698824 Positive_regulation CASP2 FAS 23618909 561688 Positive_regulation CASP2 FAS 23633472 2183100 Positive_regulation CASP2 FAS 23787996 548440 Positive_regulation CASP2 FAS 24157880 568616 Positive_regulation CASP2 FAS 24716143 1694453 Positive_regulation CASP2 FAS 25548754 219490 Positive_regulation CASP2 FAS 25594018 2173713 Positive_regulation CASP2 FAS 9730893 1603540 Positive_regulation CASP2 FAS 9730899 1603738 Positive_regulation CASP2 FAS 9730899 1603751 Positive_regulation CASP2 FAS 9730899 1603791 Positive_regulation CASP2 MAP2K6 15266324 424704 Positive_regulation CASP2 MIP 21347304 2503545 Positive_regulation CASP2 MMP28 19547714 1671192 Positive_regulation CASP2 MMP28 20416058 1854217 Positive_regulation CASP2 MMP28 25250578 3009397 Positive_regulation CASP2 MMP28 25250578 3009683 Positive_regulation CASP2 MMP7 19547714 1671207 Positive_regulation CASP2 MMP7 20416058 1854232 Positive_regulation CASP2 MMP7 25250578 3009412 Positive_regulation CASP2 MMP7 25250578 3009698 Positive_regulation CASP2 SPHK1 24572701 652053 Positive_regulation CASP2 TLR7 23762026 3062003 Positive_regulation CASP2 TNF 10727454 1514581 Positive_regulation CASP2 TNF 10839812 1515681 Positive_regulation CASP2 TNF 11381085 1270308 Positive_regulation CASP2 TNF 18625845 1353881 Positive_regulation CASP2 TNF 19440308 2416505 Positive_regulation CASP2 TNF 19440308 2416506 Positive_regulation CASP2 TNF 19440308 2416507 Positive_regulation CASP2 TNF 19440308 2416508 Positive_regulation CASP2 TNF 19440308 2416580 Positive_regulation CASP2 TNF 19440308 2416581 Positive_regulation CASP2 TNF 19440308 2416582 Positive_regulation CASP2 TNF 19440308 2416625 Positive_regulation CASP2 TNF 19440308 2416626 Positive_regulation CASP2 TNF 19440308 2416661 Positive_regulation CASP2 TNF 19440308 2416676 Positive_regulation CASP2 TNF 19440308 2416691 Positive_regulation CASP2 TNF 19440308 2416706 Positive_regulation CASP2 TNF 19440308 2416745 Positive_regulation CASP2 TNF 19440308 2416771 Positive_regulation CASP2 TNF 20200974 1237331 Positive_regulation CASP2 TNF 21559479 2520068 Positive_regulation CASP2 TNF 22036896 2176706 Positive_regulation CASP2 TNF 22089168 553462 Positive_regulation CASP2 TNF 22540228 1662224 Positive_regulation CASP2 TNF 22540228 1662239 Positive_regulation CASP2 TNF 22864384 1727524 Positive_regulation CASP2 TNF 23264463 1810452 Positive_regulation CASP2 TNF 23386613 1206369 Positive_regulation CASP2 TNF 23659427 509811 Positive_regulation CASP2 TNF 23816559 625753 Positive_regulation CASP2 TNF 24028654 622241 Positive_regulation CASP2 TNF 24028654 622267 Positive_regulation CASP2 TNF 24795644 964999 Positive_regulation CASP2 TNF 25285524 3012406 Positive_regulation CASP2 TNF 9565639 1602732 Positive_regulation CASP2 TNFSF10 19421137 2125092 Positive_regulation CASP2 TNFSF10 19547714 1671411 Positive_regulation CASP2 TNFSF10 19549337 1851019 Positive_regulation CASP2 TNFSF10 19820719 8254 Positive_regulation CASP2 TNFSF10 20416058 1854446 Positive_regulation CASP2 TNFSF10 20442774 2448916 Positive_regulation CASP2 TNFSF10 21368859 550519 Positive_regulation CASP2 TNFSF10 21513580 1861726 Positive_regulation CASP2 TNFSF10 21513580 1861792 Positive_regulation CASP2 TNFSF10 21513580 1861838 Positive_regulation CASP2 TNFSF10 21513580 1861897 Positive_regulation CASP2 TNFSF10 21513580 1861917 Positive_regulation CASP2 TNFSF10 21586138 1862026 Positive_regulation CASP2 TNFSF10 21586138 1862027 Positive_regulation CASP2 TNFSF10 21801359 260641 Positive_regulation CASP2 TNFSF10 21899742 1863328 Positive_regulation CASP2 TNFSF10 22048166 553408 Positive_regulation CASP2 TNFSF10 22174792 2582012 Positive_regulation CASP2 TNFSF10 22213832 1882511 Positive_regulation CASP2 TNFSF10 22619505 1136922 Positive_regulation CASP2 TNFSF10 22662193 2647182 Positive_regulation CASP2 TNFSF10 22860037 2671194 Positive_regulation CASP2 TNFSF10 22876188 3058783 Positive_regulation CASP2 TNFSF10 23348585 559129 Positive_regulation CASP2 TNFSF10 23348588 559148 Positive_regulation CASP2 TNFSF10 23517112 268059 Positive_regulation CASP2 TNFSF10 23818254 781071 Positive_regulation CASP2 TNFSF10 24009855 203894 Positive_regulation CASP2 TNFSF10 24147007 2869109 Positive_regulation CASP2 TNFSF10 24147007 2869131 Positive_regulation CASP2 TNFSF10 24147007 2869147 Positive_regulation CASP2 TNFSF10 24147007 2869163 Positive_regulation CASP2 TNFSF10 24147007 2869185 Positive_regulation CASP2 TNFSF10 24147007 2869198 Positive_regulation CASP2 TNFSF10 24525736 572101 Positive_regulation CASP2 TNFSF10 24618889 2933410 Positive_regulation CASP2 TNFSF10 24648844 1070654 Positive_regulation CASP2 TNFSF10 24690311 272588 Positive_regulation CASP2 TNFSF10 24745479 474629 Positive_regulation CASP2 TNFSF10 24745479 474666 Positive_regulation CASP2 TNFSF10 24745479 474749 Positive_regulation CASP2 TNFSF10 24745479 474750 Positive_regulation CASP2 TNFSF10 24745479 474751 Positive_regulation CASP2 TNFSF10 24745479 474856 Positive_regulation CASP2 TNFSF10 24745479 474893 Positive_regulation CASP2 TNFSF10 25321472 578295 Positive_regulation CASP3 ANGPT1 23554782 1226178 Positive_regulation CASP3 ANGPT1 23554782 1226189 Positive_regulation CASP3 ANGPT1 23554782 1226190 Positive_regulation CASP3 ARSA 21826202 2540783 Positive_regulation CASP3 BPI 23472073 2763862 Positive_regulation CASP3 CAPN8 15210727 1309740 Positive_regulation CASP3 CAPN8 22281016 1660901 Positive_regulation CASP3 CAPN8 23028936 2693641 Positive_regulation CASP3 CAPN8 23425388 275295 Positive_regulation CASP3 CAPN8 23425388 275450 Positive_regulation CASP3 CAPN8 23425388 275451 Positive_regulation CASP3 CAPN8 23425388 275452 Positive_regulation CASP3 CAPN8 23425388 275684 Positive_regulation CASP3 CAPN8 23425388 275685 Positive_regulation CASP3 CAPN8 23425388 275791 Positive_regulation CASP3 CAPN8 23425388 275792 Positive_regulation CASP3 CAPN8 23467460 1713340 Positive_regulation CASP3 CAPN8 25352693 1713677 Positive_regulation CASP3 CAPN8 25355189 3165467 Positive_regulation CASP3 CAPN8 9314540 1463792 Positive_regulation CASP3 CCND1 24999379 2229489 Positive_regulation CASP3 CCND1 25051362 2196777 Positive_regulation CASP3 CLDN10 22361748 554329 Positive_regulation CASP3 CLDN10 22361748 554953 Positive_regulation CASP3 CLU 22848862 2234558 Positive_regulation CASP3 CTGF 23846227 564057 Positive_regulation CASP3 EGLN3 20978507 436085 Positive_regulation CASP3 EGLN3 20978507 436087 Positive_regulation CASP3 EGLN3 22898032 1506506 Positive_regulation CASP3 EPHB2 15266324 424706 Positive_regulation CASP3 EPHB2 21037797 2301656 Positive_regulation CASP3 EPHB2 23018309 653349 Positive_regulation CASP3 EPHB2 23470533 560770 Positive_regulation CASP3 EPHB2 23542180 218395 Positive_regulation CASP3 EPHB2 23961994 1700239 Positive_regulation CASP3 EPHB2 24624962 1921287 Positive_regulation CASP3 EPHB2 24755682 2957248 Positive_regulation CASP3 EPHB2 25013376 1063074 Positive_regulation CASP3 EPHB2 25206476 2004754 Positive_regulation CASP3 EPHB2 25606044 746821 Positive_regulation CASP3 FAS 10545499 1251511 Positive_regulation CASP3 FAS 10601363 1513775 Positive_regulation CASP3 FAS 10727454 1514584 Positive_regulation CASP3 FAS 10727463 1514838 Positive_regulation CASP3 FAS 11121439 1265817 Positive_regulation CASP3 FAS 11696559 1275985 Positive_regulation CASP3 FAS 11806838 3103617 Positive_regulation CASP3 FAS 12163562 1524370 Positive_regulation CASP3 FAS 12163562 1524466 Positive_regulation CASP3 FAS 12163562 1524497 Positive_regulation CASP3 FAS 12402161 422082 Positive_regulation CASP3 FAS 14612908 423769 Positive_regulation CASP3 FAS 14738570 277397 Positive_regulation CASP3 FAS 14738570 277399 Positive_regulation CASP3 FAS 14970175 1531355 Positive_regulation CASP3 FAS 15265234 380704 Positive_regulation CASP3 FAS 15730564 382734 Positive_regulation CASP3 FAS 15857508 365173 Positive_regulation CASP3 FAS 16009715 1536894 Positive_regulation CASP3 FAS 16009715 1536895 Positive_regulation CASP3 FAS 16365167 1326348 Positive_regulation CASP3 FAS 17295922 1651108 Positive_regulation CASP3 FAS 18044074 647599 Positive_regulation CASP3 FAS 18211685 658888 Positive_regulation CASP3 FAS 18782442 111206 Positive_regulation CASP3 FAS 19171757 1363630 Positive_regulation CASP3 FAS 19936232 2431820 Positive_regulation CASP3 FAS 20353915 806582 Positive_regulation CASP3 FAS 20358022 35591 Positive_regulation CASP3 FAS 21083888 2231200 Positive_regulation CASP3 FAS 21212468 28927 Positive_regulation CASP3 FAS 21477291 527195 Positive_regulation CASP3 FAS 21477291 527205 Positive_regulation CASP3 FAS 21569413 1723613 Positive_regulation CASP3 FAS 21625644 2525260 Positive_regulation CASP3 FAS 21629700 2525598 Positive_regulation CASP3 FAS 22084408 1566102 Positive_regulation CASP3 FAS 22272214 813683 Positive_regulation CASP3 FAS 22375159 3177198 Positive_regulation CASP3 FAS 22375159 3177202 Positive_regulation CASP3 FAS 22507896 799384 Positive_regulation CASP3 FAS 22859258 1086643 Positive_regulation CASP3 FAS 22876188 3058784 Positive_regulation CASP3 FAS 22916262 2680594 Positive_regulation CASP3 FAS 22942738 1097160 Positive_regulation CASP3 FAS 23029562 2698825 Positive_regulation CASP3 FAS 23103563 154190 Positive_regulation CASP3 FAS 23181119 842716 Positive_regulation CASP3 FAS 23358309 1684706 Positive_regulation CASP3 FAS 23372841 2746218 Positive_regulation CASP3 FAS 23577779 1480336 Positive_regulation CASP3 FAS 23577779 1480459 Positive_regulation CASP3 FAS 23618909 561689 Positive_regulation CASP3 FAS 23626522 866787 Positive_regulation CASP3 FAS 23633472 2183101 Positive_regulation CASP3 FAS 23690674 1753128 Positive_regulation CASP3 FAS 23787996 548441 Positive_regulation CASP3 FAS 24031135 3230609 Positive_regulation CASP3 FAS 24031135 3230610 Positive_regulation CASP3 FAS 24031135 3230611 Positive_regulation CASP3 FAS 24031135 3230612 Positive_regulation CASP3 FAS 24031135 3230613 Positive_regulation CASP3 FAS 24157880 568617 Positive_regulation CASP3 FAS 24622841 3081748 Positive_regulation CASP3 FAS 24716143 1694455 Positive_regulation CASP3 FAS 24874741 576527 Positive_regulation CASP3 FAS 25072848 2993053 Positive_regulation CASP3 FAS 25101900 3068801 Positive_regulation CASP3 FAS 25119573 2997129 Positive_regulation CASP3 FAS 25548754 219491 Positive_regulation CASP3 FAS 25594018 2173714 Positive_regulation CASP3 FAS 9730893 1603541 Positive_regulation CASP3 FAS 9730899 1603739 Positive_regulation CASP3 FAS 9730899 1603752 Positive_regulation CASP3 FAS 9730899 1603792 Positive_regulation CASP3 FHL1 24952875 274110 Positive_regulation CASP3 FOXO1 16157701 1323943 Positive_regulation CASP3 FOXO1 16157701 1323944 Positive_regulation CASP3 FOXO1 21179458 2488099 Positive_regulation CASP3 FOXO1 21402788 1385727 Positive_regulation CASP3 FOXO1 24633305 1963966 Positive_regulation CASP3 ID1 23900621 1141953 Positive_regulation CASP3 IFI27 18725974 2395781 Positive_regulation CASP3 IFI27 23449448 560451 Positive_regulation CASP3 ITGAL 17233909 351794 Positive_regulation CASP3 ITGB2 17233909 351795 Positive_regulation CASP3 LAMB3 22673183 471591 Positive_regulation CASP3 LBP 24595452 2931332 Positive_regulation CASP3 LGALS7B 23530091 2182914 Positive_regulation CASP3 MAOA 21236334 857691 Positive_regulation CASP3 MAP2K6 15266324 424712 Positive_regulation CASP3 MAP2K6 24023725 2843413 Positive_regulation CASP3 MAP2K6 24886705 1668157 Positive_regulation CASP3 MIP 21347304 2503546 Positive_regulation CASP3 MIP 21347304 2503579 Positive_regulation CASP3 MMP28 12756268 1527215 Positive_regulation CASP3 MMP28 18629305 793071 Positive_regulation CASP3 MMP28 19547714 1671214 Positive_regulation CASP3 MMP28 19966836 8451 Positive_regulation CASP3 MMP28 19966836 8513 Positive_regulation CASP3 MMP28 20111678 1089061 Positive_regulation CASP3 MMP28 20111678 1089149 Positive_regulation CASP3 MMP28 20416058 1854240 Positive_regulation CASP3 MMP28 21423690 812427 Positive_regulation CASP3 MMP28 21595920 1697322 Positive_regulation CASP3 MMP28 23202971 1098950 Positive_regulation CASP3 MMP28 23667640 2790846 Positive_regulation CASP3 MMP28 24244749 2881558 Positive_regulation CASP3 MMP28 24324518 824447 Positive_regulation CASP3 MMP28 25250578 3009419 Positive_regulation CASP3 MMP28 25250578 3009705 Positive_regulation CASP3 MMP28 25337568 1241544 Positive_regulation CASP3 MMP28 PMC3871853 1136406 Positive_regulation CASP3 MMP7 12756268 1527230 Positive_regulation CASP3 MMP7 18629305 793086 Positive_regulation CASP3 MMP7 19547714 1671229 Positive_regulation CASP3 MMP7 19966836 8466 Positive_regulation CASP3 MMP7 19966836 8528 Positive_regulation CASP3 MMP7 20111678 1089076 Positive_regulation CASP3 MMP7 20111678 1089164 Positive_regulation CASP3 MMP7 20139113 513628 Positive_regulation CASP3 MMP7 20416058 1854255 Positive_regulation CASP3 MMP7 21423690 812442 Positive_regulation CASP3 MMP7 21595920 1697337 Positive_regulation CASP3 MMP7 23202971 1098965 Positive_regulation CASP3 MMP7 23667640 2790862 Positive_regulation CASP3 MMP7 24244749 2881573 Positive_regulation CASP3 MMP7 24324518 824462 Positive_regulation CASP3 MMP7 25250578 3009434 Positive_regulation CASP3 MMP7 25250578 3009720 Positive_regulation CASP3 MMP7 25337568 1241559 Positive_regulation CASP3 MMP7 PMC3871853 1136421 Positive_regulation CASP3 OSR1 21203417 2489924 Positive_regulation CASP3 PGC 22266669 721059 Positive_regulation CASP3 PLAT 21291561 1891920 Positive_regulation CASP3 RCAN1 24751678 2956075 Positive_regulation CASP3 RCAN1 24751678 2956077 Positive_regulation CASP3 RCAN1 25377251 1884312 Positive_regulation CASP3 S100B 20672051 512989 Positive_regulation CASP3 SPHK1 24572701 652054 Positive_regulation CASP3 TCN1 23936501 2831130 Positive_regulation CASP3 TLR7 23762026 3062013 Positive_regulation CASP3 TNF 10727454 1514583 Positive_regulation CASP3 TNF 10732775 416665 Positive_regulation CASP3 TNF 10839812 1515682 Positive_regulation CASP3 TNF 11136825 1518326 Positive_regulation CASP3 TNF 11381085 1270309 Positive_regulation CASP3 TNF 11696595 1521644 Positive_regulation CASP3 TNF 12527749 1290509 Positive_regulation CASP3 TNF 12527749 1290510 Positive_regulation CASP3 TNF 14738570 277396 Positive_regulation CASP3 TNF 14960194 656452 Positive_regulation CASP3 TNF 17718922 3108333 Positive_regulation CASP3 TNF 17718922 3108342 Positive_regulation CASP3 TNF 18625845 1353882 Positive_regulation CASP3 TNF 18768084 1036339 Positive_regulation CASP3 TNF 19060883 1983096 Positive_regulation CASP3 TNF 19060883 1983100 Positive_regulation CASP3 TNF 19421137 2125106 Positive_regulation CASP3 TNF 19440308 2416509 Positive_regulation CASP3 TNF 19440308 2416510 Positive_regulation CASP3 TNF 19440308 2416511 Positive_regulation CASP3 TNF 19440308 2416512 Positive_regulation CASP3 TNF 19440308 2416583 Positive_regulation CASP3 TNF 19440308 2416584 Positive_regulation CASP3 TNF 19440308 2416585 Positive_regulation CASP3 TNF 19440308 2416627 Positive_regulation CASP3 TNF 19440308 2416628 Positive_regulation CASP3 TNF 19440308 2416662 Positive_regulation CASP3 TNF 19440308 2416677 Positive_regulation CASP3 TNF 19440308 2416692 Positive_regulation CASP3 TNF 19440308 2416707 Positive_regulation CASP3 TNF 19440308 2416746 Positive_regulation CASP3 TNF 19440308 2416772 Positive_regulation CASP3 TNF 19818125 3091169 Positive_regulation CASP3 TNF 20200974 1237332 Positive_regulation CASP3 TNF 20200974 1237333 Positive_regulation CASP3 TNF 20200974 1237358 Positive_regulation CASP3 TNF 20693346 716073 Positive_regulation CASP3 TNF 21029292 590578 Positive_regulation CASP3 TNF 21383695 2138580 Positive_regulation CASP3 TNF 21858054 2545933 Positive_regulation CASP3 TNF 21949832 2556775 Positive_regulation CASP3 TNF 22036896 2176707 Positive_regulation CASP3 TNF 22089168 553463 Positive_regulation CASP3 TNF 22101767 1961796 Positive_regulation CASP3 TNF 22203854 1155963 Positive_regulation CASP3 TNF 22314197 834278 Positive_regulation CASP3 TNF 22540228 1662225 Positive_regulation CASP3 TNF 22540228 1662226 Positive_regulation CASP3 TNF 22540228 1662240 Positive_regulation CASP3 TNF 22540228 1662249 Positive_regulation CASP3 TNF 22540228 1662251 Positive_regulation CASP3 TNF 22540228 1662253 Positive_regulation CASP3 TNF 22763408 1918935 Positive_regulation CASP3 TNF 22768286 2660443 Positive_regulation CASP3 TNF 22864384 1727525 Positive_regulation CASP3 TNF 23028840 2693186 Positive_regulation CASP3 TNF 23028840 2693189 Positive_regulation CASP3 TNF 23028840 2693191 Positive_regulation CASP3 TNF 23028840 2693192 Positive_regulation CASP3 TNF 23193206 729922 Positive_regulation CASP3 TNF 23193206 729923 Positive_regulation CASP3 TNF 23193206 729924 Positive_regulation CASP3 TNF 23193206 729925 Positive_regulation CASP3 TNF 23193206 729926 Positive_regulation CASP3 TNF 23202309 3184263 Positive_regulation CASP3 TNF 23264463 1810453 Positive_regulation CASP3 TNF 23328672 559021 Positive_regulation CASP3 TNF 23386613 1206370 Positive_regulation CASP3 TNF 23474627 31197 Positive_regulation CASP3 TNF 23476127 3154115 Positive_regulation CASP3 TNF 23659427 509812 Positive_regulation CASP3 TNF 23816559 625754 Positive_regulation CASP3 TNF 23882270 908317 Positive_regulation CASP3 TNF 24028654 622242 Positive_regulation CASP3 TNF 24028654 622268 Positive_regulation CASP3 TNF 24039713 2844591 Positive_regulation CASP3 TNF 24327924 1831672 Positive_regulation CASP3 TNF 24382946 3155668 Positive_regulation CASP3 TNF 24484528 856862 Positive_regulation CASP3 TNF 24638205 3223802 Positive_regulation CASP3 TNF 24739976 2118817 Positive_regulation CASP3 TNF 24795644 965000 Positive_regulation CASP3 TNF 24857910 1127038 Positive_regulation CASP3 TNF 25162582 3002957 Positive_regulation CASP3 TNF 25258680 1675233 Positive_regulation CASP3 TNF 25285524 3012407 Positive_regulation CASP3 TNF 25290670 3012576 Positive_regulation CASP3 TNF 25290670 3012581 Positive_regulation CASP3 TNF 25298670 2248185 Positive_regulation CASP3 TNF 25298670 2248186 Positive_regulation CASP3 TNF 25443632 762683 Positive_regulation CASP3 TNF 25443632 762687 Positive_regulation CASP3 TNF 25443632 762697 Positive_regulation CASP3 TNF 25502757 841169 Positive_regulation CASP3 TNF 25502757 841175 Positive_regulation CASP3 TNF 9034139 1600010 Positive_regulation CASP3 TNF 9034139 1600011 Positive_regulation CASP3 TNF 9565639 1602733 Positive_regulation CASP3 TNFSF10 17177999 480410 Positive_regulation CASP3 TNFSF10 19196465 112770 Positive_regulation CASP3 TNFSF10 19421137 2125084 Positive_regulation CASP3 TNFSF10 19421137 2125086 Positive_regulation CASP3 TNFSF10 19421137 2125093 Positive_regulation CASP3 TNFSF10 19421137 2125103 Positive_regulation CASP3 TNFSF10 19547714 1671412 Positive_regulation CASP3 TNFSF10 19549337 1851020 Positive_regulation CASP3 TNFSF10 19820719 8255 Positive_regulation CASP3 TNFSF10 19881910 672070 Positive_regulation CASP3 TNFSF10 19881910 672077 Positive_regulation CASP3 TNFSF10 20113484 1853240 Positive_regulation CASP3 TNFSF10 20230625 328667 Positive_regulation CASP3 TNFSF10 20230625 328669 Positive_regulation CASP3 TNFSF10 20398369 1853923 Positive_regulation CASP3 TNFSF10 20442774 2448917 Positive_regulation CASP3 TNFSF10 20646307 256710 Positive_regulation CASP3 TNFSF10 20661217 2133147 Positive_regulation CASP3 TNFSF10 20661217 2133149 Positive_regulation CASP3 TNFSF10 20663232 1857138 Positive_regulation CASP3 TNFSF10 20977779 257740 Positive_regulation CASP3 TNFSF10 21368859 550527 Positive_regulation CASP3 TNFSF10 21513580 1861728 Positive_regulation CASP3 TNFSF10 21513580 1861794 Positive_regulation CASP3 TNFSF10 21513580 1861841 Positive_regulation CASP3 TNFSF10 21513580 1861898 Positive_regulation CASP3 TNFSF10 21513580 1861920 Positive_regulation CASP3 TNFSF10 21586138 1862029 Positive_regulation CASP3 TNFSF10 21586138 1862030 Positive_regulation CASP3 TNFSF10 21801359 260642 Positive_regulation CASP3 TNFSF10 21801359 260664 Positive_regulation CASP3 TNFSF10 21801359 260667 Positive_regulation CASP3 TNFSF10 21824395 3112501 Positive_regulation CASP3 TNFSF10 21899742 1863330 Positive_regulation CASP3 TNFSF10 22048166 553351 Positive_regulation CASP3 TNFSF10 22048166 553360 Positive_regulation CASP3 TNFSF10 22048166 553374 Positive_regulation CASP3 TNFSF10 22048166 553409 Positive_regulation CASP3 TNFSF10 22048166 553419 Positive_regulation CASP3 TNFSF10 22174792 2582014 Positive_regulation CASP3 TNFSF10 22179661 1140760 Positive_regulation CASP3 TNFSF10 22179661 1140761 Positive_regulation CASP3 TNFSF10 22213832 1882512 Positive_regulation CASP3 TNFSF10 22613960 1140851 Positive_regulation CASP3 TNFSF10 22619505 1136924 Positive_regulation CASP3 TNFSF10 22662193 2647183 Positive_regulation CASP3 TNFSF10 22733138 2147704 Positive_regulation CASP3 TNFSF10 22733138 2147710 Positive_regulation CASP3 TNFSF10 22860037 2671195 Positive_regulation CASP3 TNFSF10 22876188 3058785 Positive_regulation CASP3 TNFSF10 22932446 834908 Positive_regulation CASP3 TNFSF10 23018355 1735707 Positive_regulation CASP3 TNFSF10 23289871 411589 Positive_regulation CASP3 TNFSF10 23348585 559130 Positive_regulation CASP3 TNFSF10 23348588 559149 Positive_regulation CASP3 TNFSF10 23348588 559150 Positive_regulation CASP3 TNFSF10 23348588 559151 Positive_regulation CASP3 TNFSF10 23348588 559152 Positive_regulation CASP3 TNFSF10 23348588 559178 Positive_regulation CASP3 TNFSF10 23348588 559179 Positive_regulation CASP3 TNFSF10 23348588 559182 Positive_regulation CASP3 TNFSF10 23370279 559378 Positive_regulation CASP3 TNFSF10 23370279 559379 Positive_regulation CASP3 TNFSF10 23370279 559384 Positive_regulation CASP3 TNFSF10 23370279 559388 Positive_regulation CASP3 TNFSF10 23470485 2182450 Positive_regulation CASP3 TNFSF10 23517112 268060 Positive_regulation CASP3 TNFSF10 23573148 818508 Positive_regulation CASP3 TNFSF10 23703388 561924 Positive_regulation CASP3 TNFSF10 23703388 561928 Positive_regulation CASP3 TNFSF10 23703388 561934 Positive_regulation CASP3 TNFSF10 23703388 561935 Positive_regulation CASP3 TNFSF10 23703388 561946 Positive_regulation CASP3 TNFSF10 23703388 561948 Positive_regulation CASP3 TNFSF10 23818254 781072 Positive_regulation CASP3 TNFSF10 23921681 1109718 Positive_regulation CASP3 TNFSF10 24009855 203895 Positive_regulation CASP3 TNFSF10 24147007 2869110 Positive_regulation CASP3 TNFSF10 24147007 2869132 Positive_regulation CASP3 TNFSF10 24147007 2869148 Positive_regulation CASP3 TNFSF10 24147007 2869164 Positive_regulation CASP3 TNFSF10 24147007 2869186 Positive_regulation CASP3 TNFSF10 24147007 2869199 Positive_regulation CASP3 TNFSF10 24525736 572102 Positive_regulation CASP3 TNFSF10 24603337 572760 Positive_regulation CASP3 TNFSF10 24618889 2933411 Positive_regulation CASP3 TNFSF10 24648844 1070655 Positive_regulation CASP3 TNFSF10 24667731 2939090 Positive_regulation CASP3 TNFSF10 24690311 272555 Positive_regulation CASP3 TNFSF10 24690311 272589 Positive_regulation CASP3 TNFSF10 24745479 474631 Positive_regulation CASP3 TNFSF10 24745479 474632 Positive_regulation CASP3 TNFSF10 24745479 474633 Positive_regulation CASP3 TNFSF10 24745479 474634 Positive_regulation CASP3 TNFSF10 24745479 474635 Positive_regulation CASP3 TNFSF10 24745479 474636 Positive_regulation CASP3 TNFSF10 24745479 474637 Positive_regulation CASP3 TNFSF10 24745479 474638 Positive_regulation CASP3 TNFSF10 24745479 474639 Positive_regulation CASP3 TNFSF10 24745479 474667 Positive_regulation CASP3 TNFSF10 24745479 474668 Positive_regulation CASP3 TNFSF10 24745479 474669 Positive_regulation CASP3 TNFSF10 24745479 474670 Positive_regulation CASP3 TNFSF10 24745479 474671 Positive_regulation CASP3 TNFSF10 24745479 474672 Positive_regulation CASP3 TNFSF10 24745479 474673 Positive_regulation CASP3 TNFSF10 24745479 474674 Positive_regulation CASP3 TNFSF10 24745479 474675 Positive_regulation CASP3 TNFSF10 24745479 474676 Positive_regulation CASP3 TNFSF10 24745479 474677 Positive_regulation CASP3 TNFSF10 24745479 474678 Positive_regulation CASP3 TNFSF10 24745479 474679 Positive_regulation CASP3 TNFSF10 24745479 474680 Positive_regulation CASP3 TNFSF10 24745479 474681 Positive_regulation CASP3 TNFSF10 24745479 474682 Positive_regulation CASP3 TNFSF10 24745479 474683 Positive_regulation CASP3 TNFSF10 24745479 474684 Positive_regulation CASP3 TNFSF10 24745479 474685 Positive_regulation CASP3 TNFSF10 24745479 474686 Positive_regulation CASP3 TNFSF10 24745479 474687 Positive_regulation CASP3 TNFSF10 24745479 474752 Positive_regulation CASP3 TNFSF10 24745479 474753 Positive_regulation CASP3 TNFSF10 24745479 474754 Positive_regulation CASP3 TNFSF10 24745479 474755 Positive_regulation CASP3 TNFSF10 24745479 474756 Positive_regulation CASP3 TNFSF10 24745479 474757 Positive_regulation CASP3 TNFSF10 24745479 474758 Positive_regulation CASP3 TNFSF10 24745479 474759 Positive_regulation CASP3 TNFSF10 24745479 474760 Positive_regulation CASP3 TNFSF10 24745479 474761 Positive_regulation CASP3 TNFSF10 24745479 474762 Positive_regulation CASP3 TNFSF10 24745479 474763 Positive_regulation CASP3 TNFSF10 24745479 474764 Positive_regulation CASP3 TNFSF10 24745479 474819 Positive_regulation CASP3 TNFSF10 24745479 474820 Positive_regulation CASP3 TNFSF10 24745479 474821 Positive_regulation CASP3 TNFSF10 24745479 474822 Positive_regulation CASP3 TNFSF10 24745479 474823 Positive_regulation CASP3 TNFSF10 24745479 474824 Positive_regulation CASP3 TNFSF10 24745479 474825 Positive_regulation CASP3 TNFSF10 24745479 474826 Positive_regulation CASP3 TNFSF10 24745479 474827 Positive_regulation CASP3 TNFSF10 24745479 474828 Positive_regulation CASP3 TNFSF10 24745479 474829 Positive_regulation CASP3 TNFSF10 24745479 474830 Positive_regulation CASP3 TNFSF10 24745479 474831 Positive_regulation CASP3 TNFSF10 24745479 474857 Positive_regulation CASP3 TNFSF10 24745479 474858 Positive_regulation CASP3 TNFSF10 24745479 474859 Positive_regulation CASP3 TNFSF10 24745479 474860 Positive_regulation CASP3 TNFSF10 24745479 474861 Positive_regulation CASP3 TNFSF10 24745479 474878 Positive_regulation CASP3 TNFSF10 24745479 474879 Positive_regulation CASP3 TNFSF10 24745479 474880 Positive_regulation CASP3 TNFSF10 24745479 474881 Positive_regulation CASP3 TNFSF10 24745479 474882 Positive_regulation CASP3 TNFSF10 24745479 474894 Positive_regulation CASP3 TNFSF10 24745479 474895 Positive_regulation CASP3 TNFSF10 24745479 474896 Positive_regulation CASP3 TNFSF10 24745479 474897 Positive_regulation CASP3 TNFSF10 24745479 474898 Positive_regulation CASP3 TNFSF10 24745479 474942 Positive_regulation CASP3 TNFSF10 24745479 474963 Positive_regulation CASP3 TNFSF10 24910845 948146 Positive_regulation CASP3 TNFSF10 24971369 1621812 Positive_regulation CASP3 TNFSF10 25321472 578296 Positive_regulation CASP3 TNFSF10 25349561 1147453 Positive_regulation CASP3 TNFSF10 25395862 2123722 Positive_regulation CASP3 TNFSF10 25398248 1018802 Positive_regulation CASP3 TNFSF10 25398248 1018804 Positive_regulation CASP3 TNFSF10 25398248 1018806 Positive_regulation CASP3 TP63 20429941 328920 Positive_regulation CASP3 UNC5B 21460185 1789340 Positive_regulation CASP3 UNC5B 24720832 1482997 Positive_regulation CASP3 UNC5B 24720832 1483008 Positive_regulation CASP3 ZFP57 24722354 2951277 Positive_regulation CASP4 CAPN8 15210727 1309754 Positive_regulation CASP4 CAPN8 21490804 1638363 Positive_regulation CASP4 CAPN8 22281016 1660915 Positive_regulation CASP4 CAPN8 9314540 1463806 Positive_regulation CASP4 CLDN10 22361748 554355 Positive_regulation CASP4 EPHB2 15266324 424714 Positive_regulation CASP4 EPHB2 21037797 2301657 Positive_regulation CASP4 EPHB2 23018309 653350 Positive_regulation CASP4 EPHB2 25013376 1063075 Positive_regulation CASP4 EPHB2 25606044 746823 Positive_regulation CASP4 FAS 10727454 1514586 Positive_regulation CASP4 FAS 11121439 1265818 Positive_regulation CASP4 FAS 11696559 1275987 Positive_regulation CASP4 FAS 12163562 1524371 Positive_regulation CASP4 FAS 12163562 1524467 Positive_regulation CASP4 FAS 12163562 1524498 Positive_regulation CASP4 FAS 14612908 423770 Positive_regulation CASP4 FAS 15857508 365174 Positive_regulation CASP4 FAS 16365167 1326349 Positive_regulation CASP4 FAS 17295922 1651110 Positive_regulation CASP4 FAS 21083888 2231203 Positive_regulation CASP4 FAS 21212468 28928 Positive_regulation CASP4 FAS 21477291 527196 Positive_regulation CASP4 FAS 21569413 1723615 Positive_regulation CASP4 FAS 21625644 2525261 Positive_regulation CASP4 FAS 21629700 2525599 Positive_regulation CASP4 FAS 22084408 1566104 Positive_regulation CASP4 FAS 22859258 1086644 Positive_regulation CASP4 FAS 22876188 3058786 Positive_regulation CASP4 FAS 22942738 1097162 Positive_regulation CASP4 FAS 23029562 2698826 Positive_regulation CASP4 FAS 23618909 561690 Positive_regulation CASP4 FAS 23633472 2183102 Positive_regulation CASP4 FAS 23787996 548442 Positive_regulation CASP4 FAS 24157880 568618 Positive_regulation CASP4 FAS 24716143 1694457 Positive_regulation CASP4 FAS 25548754 219492 Positive_regulation CASP4 FAS 25594018 2173715 Positive_regulation CASP4 FAS 9730893 1603542 Positive_regulation CASP4 FAS 9730899 1603740 Positive_regulation CASP4 FAS 9730899 1603753 Positive_regulation CASP4 FAS 9730899 1603793 Positive_regulation CASP4 MAP2K6 15266324 424720 Positive_regulation CASP4 MIP 21347304 2503547 Positive_regulation CASP4 MMP28 19547714 1671236 Positive_regulation CASP4 MMP28 20416058 1854263 Positive_regulation CASP4 MMP28 25250578 3009441 Positive_regulation CASP4 MMP28 25250578 3009727 Positive_regulation CASP4 MMP7 19547714 1671251 Positive_regulation CASP4 MMP7 20416058 1854278 Positive_regulation CASP4 MMP7 25250578 3009456 Positive_regulation CASP4 MMP7 25250578 3009742 Positive_regulation CASP4 SPHK1 24572701 652055 Positive_regulation CASP4 TLR7 23762026 3062023 Positive_regulation CASP4 TNF 10727454 1514585 Positive_regulation CASP4 TNF 10839812 1515683 Positive_regulation CASP4 TNF 11381085 1270310 Positive_regulation CASP4 TNF 18625845 1353883 Positive_regulation CASP4 TNF 19440308 2416513 Positive_regulation CASP4 TNF 19440308 2416514 Positive_regulation CASP4 TNF 19440308 2416515 Positive_regulation CASP4 TNF 19440308 2416516 Positive_regulation CASP4 TNF 19440308 2416586 Positive_regulation CASP4 TNF 19440308 2416587 Positive_regulation CASP4 TNF 19440308 2416588 Positive_regulation CASP4 TNF 19440308 2416629 Positive_regulation CASP4 TNF 19440308 2416630 Positive_regulation CASP4 TNF 19440308 2416663 Positive_regulation CASP4 TNF 19440308 2416678 Positive_regulation CASP4 TNF 19440308 2416693 Positive_regulation CASP4 TNF 19440308 2416708 Positive_regulation CASP4 TNF 19440308 2416747 Positive_regulation CASP4 TNF 19440308 2416773 Positive_regulation CASP4 TNF 20200974 1237334 Positive_regulation CASP4 TNF 22036896 2176708 Positive_regulation CASP4 TNF 22089168 553464 Positive_regulation CASP4 TNF 22540228 1662227 Positive_regulation CASP4 TNF 22540228 1662241 Positive_regulation CASP4 TNF 22864384 1727526 Positive_regulation CASP4 TNF 23264463 1810454 Positive_regulation CASP4 TNF 23386613 1206371 Positive_regulation CASP4 TNF 23659427 509813 Positive_regulation CASP4 TNF 23816559 625755 Positive_regulation CASP4 TNF 24028654 622243 Positive_regulation CASP4 TNF 24028654 622269 Positive_regulation CASP4 TNF 24795644 965001 Positive_regulation CASP4 TNF 25285524 3012408 Positive_regulation CASP4 TNF 9565639 1602734 Positive_regulation CASP4 TNFSF10 19421137 2125094 Positive_regulation CASP4 TNFSF10 19547714 1671413 Positive_regulation CASP4 TNFSF10 19549337 1851021 Positive_regulation CASP4 TNFSF10 19820719 8256 Positive_regulation CASP4 TNFSF10 20442774 2448918 Positive_regulation CASP4 TNFSF10 21368859 550535 Positive_regulation CASP4 TNFSF10 21513580 1861730 Positive_regulation CASP4 TNFSF10 21513580 1861796 Positive_regulation CASP4 TNFSF10 21513580 1861844 Positive_regulation CASP4 TNFSF10 21513580 1861899 Positive_regulation CASP4 TNFSF10 21513580 1861923 Positive_regulation CASP4 TNFSF10 21586138 1862032 Positive_regulation CASP4 TNFSF10 21586138 1862033 Positive_regulation CASP4 TNFSF10 21801359 260643 Positive_regulation CASP4 TNFSF10 21899742 1863332 Positive_regulation CASP4 TNFSF10 22048166 553410 Positive_regulation CASP4 TNFSF10 22174792 2582016 Positive_regulation CASP4 TNFSF10 22213832 1882513 Positive_regulation CASP4 TNFSF10 22619505 1136926 Positive_regulation CASP4 TNFSF10 22662193 2647184 Positive_regulation CASP4 TNFSF10 22860037 2671196 Positive_regulation CASP4 TNFSF10 22876188 3058787 Positive_regulation CASP4 TNFSF10 23348585 559131 Positive_regulation CASP4 TNFSF10 23348588 559153 Positive_regulation CASP4 TNFSF10 23517112 268061 Positive_regulation CASP4 TNFSF10 23818254 781073 Positive_regulation CASP4 TNFSF10 24009855 203896 Positive_regulation CASP4 TNFSF10 24147007 2869111 Positive_regulation CASP4 TNFSF10 24147007 2869133 Positive_regulation CASP4 TNFSF10 24147007 2869149 Positive_regulation CASP4 TNFSF10 24147007 2869165 Positive_regulation CASP4 TNFSF10 24147007 2869187 Positive_regulation CASP4 TNFSF10 24147007 2869200 Positive_regulation CASP4 TNFSF10 24525736 572103 Positive_regulation CASP4 TNFSF10 24618889 2933412 Positive_regulation CASP4 TNFSF10 24648844 1070656 Positive_regulation CASP4 TNFSF10 24690311 272590 Positive_regulation CASP4 TNFSF10 24745479 474640 Positive_regulation CASP4 TNFSF10 24745479 474691 Positive_regulation CASP4 TNFSF10 24745479 474766 Positive_regulation CASP4 TNFSF10 24745479 474767 Positive_regulation CASP4 TNFSF10 24745479 474862 Positive_regulation CASP4 TNFSF10 24745479 474899 Positive_regulation CASP4 TNFSF10 25321472 578310 Positive_regulation CASP5 CAPN8 15210727 1309768 Positive_regulation CASP5 CAPN8 22281016 1660929 Positive_regulation CASP5 CAPN8 9314540 1463820 Positive_regulation CASP5 CLDN10 22361748 554380 Positive_regulation CASP5 EPHB2 15266324 424722 Positive_regulation CASP5 EPHB2 21037797 2301658 Positive_regulation CASP5 EPHB2 23018309 653351 Positive_regulation CASP5 EPHB2 25013376 1063076 Positive_regulation CASP5 EPHB2 25606044 746825 Positive_regulation CASP5 FAS 10727454 1514588 Positive_regulation CASP5 FAS 11121439 1265819 Positive_regulation CASP5 FAS 11696559 1275989 Positive_regulation CASP5 FAS 12163562 1524372 Positive_regulation CASP5 FAS 12163562 1524468 Positive_regulation CASP5 FAS 12163562 1524499 Positive_regulation CASP5 FAS 14612908 423771 Positive_regulation CASP5 FAS 15857508 365175 Positive_regulation CASP5 FAS 16365167 1326350 Positive_regulation CASP5 FAS 17295922 1651112 Positive_regulation CASP5 FAS 21083888 2231206 Positive_regulation CASP5 FAS 21212468 28929 Positive_regulation CASP5 FAS 21477291 527197 Positive_regulation CASP5 FAS 21569413 1723617 Positive_regulation CASP5 FAS 21625644 2525262 Positive_regulation CASP5 FAS 21629700 2525600 Positive_regulation CASP5 FAS 22084408 1566106 Positive_regulation CASP5 FAS 22859258 1086645 Positive_regulation CASP5 FAS 22876188 3058788 Positive_regulation CASP5 FAS 22942738 1097164 Positive_regulation CASP5 FAS 23029562 2698827 Positive_regulation CASP5 FAS 23618909 561691 Positive_regulation CASP5 FAS 23633472 2183103 Positive_regulation CASP5 FAS 23787996 548443 Positive_regulation CASP5 FAS 24157880 568619 Positive_regulation CASP5 FAS 24716143 1694459 Positive_regulation CASP5 FAS 25548754 219493 Positive_regulation CASP5 FAS 25594018 2173716 Positive_regulation CASP5 FAS 9730893 1603543 Positive_regulation CASP5 FAS 9730899 1603741 Positive_regulation CASP5 FAS 9730899 1603754 Positive_regulation CASP5 FAS 9730899 1603794 Positive_regulation CASP5 MAP2K6 15266324 424728 Positive_regulation CASP5 MIP 21347304 2503548 Positive_regulation CASP5 MMP28 19547714 1671258 Positive_regulation CASP5 MMP28 20416058 1854286 Positive_regulation CASP5 MMP28 25250578 3009463 Positive_regulation CASP5 MMP28 25250578 3009749 Positive_regulation CASP5 MMP7 19547714 1671273 Positive_regulation CASP5 MMP7 20416058 1854301 Positive_regulation CASP5 MMP7 25250578 3009478 Positive_regulation CASP5 MMP7 25250578 3009764 Positive_regulation CASP5 SPHK1 24572701 652056 Positive_regulation CASP5 TLR7 23762026 3062033 Positive_regulation CASP5 TNF 10727454 1514587 Positive_regulation CASP5 TNF 10839812 1515684 Positive_regulation CASP5 TNF 11381085 1270311 Positive_regulation CASP5 TNF 18625845 1353884 Positive_regulation CASP5 TNF 19440308 2416517 Positive_regulation CASP5 TNF 19440308 2416518 Positive_regulation CASP5 TNF 19440308 2416519 Positive_regulation CASP5 TNF 19440308 2416520 Positive_regulation CASP5 TNF 19440308 2416589 Positive_regulation CASP5 TNF 19440308 2416590 Positive_regulation CASP5 TNF 19440308 2416591 Positive_regulation CASP5 TNF 19440308 2416631 Positive_regulation CASP5 TNF 19440308 2416632 Positive_regulation CASP5 TNF 19440308 2416664 Positive_regulation CASP5 TNF 19440308 2416679 Positive_regulation CASP5 TNF 19440308 2416694 Positive_regulation CASP5 TNF 19440308 2416709 Positive_regulation CASP5 TNF 19440308 2416748 Positive_regulation CASP5 TNF 19440308 2416774 Positive_regulation CASP5 TNF 20200974 1237335 Positive_regulation CASP5 TNF 22036896 2176709 Positive_regulation CASP5 TNF 22089168 553465 Positive_regulation CASP5 TNF 22540228 1662228 Positive_regulation CASP5 TNF 22540228 1662242 Positive_regulation CASP5 TNF 22864384 1727527 Positive_regulation CASP5 TNF 23264463 1810455 Positive_regulation CASP5 TNF 23386613 1206372 Positive_regulation CASP5 TNF 23659427 509814 Positive_regulation CASP5 TNF 23816559 625756 Positive_regulation CASP5 TNF 24028654 622244 Positive_regulation CASP5 TNF 24028654 622270 Positive_regulation CASP5 TNF 24795644 965002 Positive_regulation CASP5 TNF 25285524 3012409 Positive_regulation CASP5 TNF 9565639 1602735 Positive_regulation CASP5 TNFSF10 19421137 2125095 Positive_regulation CASP5 TNFSF10 19547714 1671414 Positive_regulation CASP5 TNFSF10 19549337 1851022 Positive_regulation CASP5 TNFSF10 19820719 8257 Positive_regulation CASP5 TNFSF10 20442774 2448919 Positive_regulation CASP5 TNFSF10 21368859 550543 Positive_regulation CASP5 TNFSF10 21513580 1861732 Positive_regulation CASP5 TNFSF10 21513580 1861798 Positive_regulation CASP5 TNFSF10 21513580 1861847 Positive_regulation CASP5 TNFSF10 21513580 1861900 Positive_regulation CASP5 TNFSF10 21513580 1861926 Positive_regulation CASP5 TNFSF10 21586138 1862035 Positive_regulation CASP5 TNFSF10 21586138 1862036 Positive_regulation CASP5 TNFSF10 21801359 260644 Positive_regulation CASP5 TNFSF10 21899742 1863334 Positive_regulation CASP5 TNFSF10 22048166 553411 Positive_regulation CASP5 TNFSF10 22174792 2582018 Positive_regulation CASP5 TNFSF10 22213832 1882514 Positive_regulation CASP5 TNFSF10 22619505 1136928 Positive_regulation CASP5 TNFSF10 22662193 2647185 Positive_regulation CASP5 TNFSF10 22860037 2671197 Positive_regulation CASP5 TNFSF10 22876188 3058789 Positive_regulation CASP5 TNFSF10 23348585 559132 Positive_regulation CASP5 TNFSF10 23348588 559154 Positive_regulation CASP5 TNFSF10 23517112 268062 Positive_regulation CASP5 TNFSF10 23818254 781074 Positive_regulation CASP5 TNFSF10 24009855 203897 Positive_regulation CASP5 TNFSF10 24147007 2869112 Positive_regulation CASP5 TNFSF10 24147007 2869134 Positive_regulation CASP5 TNFSF10 24147007 2869150 Positive_regulation CASP5 TNFSF10 24147007 2869166 Positive_regulation CASP5 TNFSF10 24147007 2869188 Positive_regulation CASP5 TNFSF10 24147007 2869201 Positive_regulation CASP5 TNFSF10 24525736 572104 Positive_regulation CASP5 TNFSF10 24618889 2933413 Positive_regulation CASP5 TNFSF10 24648844 1070657 Positive_regulation CASP5 TNFSF10 24690311 272591 Positive_regulation CASP5 TNFSF10 24745479 474641 Positive_regulation CASP5 TNFSF10 24745479 474692 Positive_regulation CASP5 TNFSF10 24745479 474768 Positive_regulation CASP5 TNFSF10 24745479 474769 Positive_regulation CASP5 TNFSF10 24745479 474863 Positive_regulation CASP5 TNFSF10 24745479 474900 Positive_regulation CASP5 TNFSF10 25321472 578311 Positive_regulation CASP6 CAPN8 15210727 1309782 Positive_regulation CASP6 CAPN8 22281016 1660943 Positive_regulation CASP6 CAPN8 9314540 1463834 Positive_regulation CASP6 CLDN10 22361748 554405 Positive_regulation CASP6 EPHB2 15266324 424730 Positive_regulation CASP6 EPHB2 21037797 2301659 Positive_regulation CASP6 EPHB2 23018309 653352 Positive_regulation CASP6 EPHB2 25013376 1063077 Positive_regulation CASP6 EPHB2 25606044 746827 Positive_regulation CASP6 FAS 10727454 1514590 Positive_regulation CASP6 FAS 11121439 1265820 Positive_regulation CASP6 FAS 11696559 1275991 Positive_regulation CASP6 FAS 12163562 1524373 Positive_regulation CASP6 FAS 12163562 1524469 Positive_regulation CASP6 FAS 12163562 1524500 Positive_regulation CASP6 FAS 14612908 423772 Positive_regulation CASP6 FAS 15857508 365176 Positive_regulation CASP6 FAS 16365167 1326351 Positive_regulation CASP6 FAS 17295922 1651114 Positive_regulation CASP6 FAS 21083888 2231209 Positive_regulation CASP6 FAS 21212468 28930 Positive_regulation CASP6 FAS 21477291 527198 Positive_regulation CASP6 FAS 21569413 1723619 Positive_regulation CASP6 FAS 21625644 2525263 Positive_regulation CASP6 FAS 21629700 2525601 Positive_regulation CASP6 FAS 22084408 1566108 Positive_regulation CASP6 FAS 22859258 1086646 Positive_regulation CASP6 FAS 22876188 3058790 Positive_regulation CASP6 FAS 22942738 1097166 Positive_regulation CASP6 FAS 23029562 2698828 Positive_regulation CASP6 FAS 23618909 561692 Positive_regulation CASP6 FAS 23633472 2183104 Positive_regulation CASP6 FAS 23787996 548444 Positive_regulation CASP6 FAS 24157880 568620 Positive_regulation CASP6 FAS 24716143 1694461 Positive_regulation CASP6 FAS 25548754 219494 Positive_regulation CASP6 FAS 25594018 2173717 Positive_regulation CASP6 FAS 9730893 1603544 Positive_regulation CASP6 FAS 9730899 1603742 Positive_regulation CASP6 FAS 9730899 1603755 Positive_regulation CASP6 FAS 9730899 1603795 Positive_regulation CASP6 MAP2K6 15266324 424736 Positive_regulation CASP6 MIP 21347304 2503549 Positive_regulation CASP6 MMP28 19547714 1671280 Positive_regulation CASP6 MMP28 20416058 1854309 Positive_regulation CASP6 MMP28 25250578 3009485 Positive_regulation CASP6 MMP28 25250578 3009771 Positive_regulation CASP6 MMP7 19547714 1671295 Positive_regulation CASP6 MMP7 20416058 1854324 Positive_regulation CASP6 MMP7 25250578 3009500 Positive_regulation CASP6 MMP7 25250578 3009786 Positive_regulation CASP6 SPHK1 24572701 652057 Positive_regulation CASP6 TLR7 23762026 3062043 Positive_regulation CASP6 TNF 10727454 1514589 Positive_regulation CASP6 TNF 10839812 1515685 Positive_regulation CASP6 TNF 11381085 1270312 Positive_regulation CASP6 TNF 18625845 1353885 Positive_regulation CASP6 TNF 19440308 2416521 Positive_regulation CASP6 TNF 19440308 2416522 Positive_regulation CASP6 TNF 19440308 2416523 Positive_regulation CASP6 TNF 19440308 2416524 Positive_regulation CASP6 TNF 19440308 2416592 Positive_regulation CASP6 TNF 19440308 2416593 Positive_regulation CASP6 TNF 19440308 2416594 Positive_regulation CASP6 TNF 19440308 2416633 Positive_regulation CASP6 TNF 19440308 2416634 Positive_regulation CASP6 TNF 19440308 2416665 Positive_regulation CASP6 TNF 19440308 2416680 Positive_regulation CASP6 TNF 19440308 2416695 Positive_regulation CASP6 TNF 19440308 2416710 Positive_regulation CASP6 TNF 19440308 2416749 Positive_regulation CASP6 TNF 19440308 2416775 Positive_regulation CASP6 TNF 20200974 1237336 Positive_regulation CASP6 TNF 22036896 2176710 Positive_regulation CASP6 TNF 22089168 553466 Positive_regulation CASP6 TNF 22540228 1662229 Positive_regulation CASP6 TNF 22540228 1662243 Positive_regulation CASP6 TNF 22864384 1727528 Positive_regulation CASP6 TNF 23264463 1810456 Positive_regulation CASP6 TNF 23386613 1206373 Positive_regulation CASP6 TNF 23659427 509815 Positive_regulation CASP6 TNF 23816559 625757 Positive_regulation CASP6 TNF 24028654 622245 Positive_regulation CASP6 TNF 24028654 622271 Positive_regulation CASP6 TNF 24795644 965003 Positive_regulation CASP6 TNF 25285524 3012410 Positive_regulation CASP6 TNF 9565639 1602736 Positive_regulation CASP6 TNFSF10 19421137 2125096 Positive_regulation CASP6 TNFSF10 19547714 1671415 Positive_regulation CASP6 TNFSF10 19549337 1851023 Positive_regulation CASP6 TNFSF10 19820719 8258 Positive_regulation CASP6 TNFSF10 20442774 2448920 Positive_regulation CASP6 TNFSF10 21368859 550551 Positive_regulation CASP6 TNFSF10 21513580 1861734 Positive_regulation CASP6 TNFSF10 21513580 1861800 Positive_regulation CASP6 TNFSF10 21513580 1861850 Positive_regulation CASP6 TNFSF10 21513580 1861901 Positive_regulation CASP6 TNFSF10 21513580 1861929 Positive_regulation CASP6 TNFSF10 21586138 1862038 Positive_regulation CASP6 TNFSF10 21586138 1862039 Positive_regulation CASP6 TNFSF10 21801359 260645 Positive_regulation CASP6 TNFSF10 21899742 1863336 Positive_regulation CASP6 TNFSF10 22048166 553412 Positive_regulation CASP6 TNFSF10 22174792 2582020 Positive_regulation CASP6 TNFSF10 22213832 1882515 Positive_regulation CASP6 TNFSF10 22619505 1136930 Positive_regulation CASP6 TNFSF10 22662193 2647186 Positive_regulation CASP6 TNFSF10 22860037 2671198 Positive_regulation CASP6 TNFSF10 22876188 3058791 Positive_regulation CASP6 TNFSF10 23348585 559133 Positive_regulation CASP6 TNFSF10 23348588 559155 Positive_regulation CASP6 TNFSF10 23517112 268063 Positive_regulation CASP6 TNFSF10 23818254 781075 Positive_regulation CASP6 TNFSF10 24009855 203898 Positive_regulation CASP6 TNFSF10 24147007 2869113 Positive_regulation CASP6 TNFSF10 24147007 2869135 Positive_regulation CASP6 TNFSF10 24147007 2869151 Positive_regulation CASP6 TNFSF10 24147007 2869167 Positive_regulation CASP6 TNFSF10 24147007 2869189 Positive_regulation CASP6 TNFSF10 24147007 2869202 Positive_regulation CASP6 TNFSF10 24525736 572105 Positive_regulation CASP6 TNFSF10 24618889 2933414 Positive_regulation CASP6 TNFSF10 24648844 1070658 Positive_regulation CASP6 TNFSF10 24690311 272592 Positive_regulation CASP6 TNFSF10 24745479 474642 Positive_regulation CASP6 TNFSF10 24745479 474693 Positive_regulation CASP6 TNFSF10 24745479 474770 Positive_regulation CASP6 TNFSF10 24745479 474771 Positive_regulation CASP6 TNFSF10 24745479 474864 Positive_regulation CASP6 TNFSF10 24745479 474901 Positive_regulation CASP6 TNFSF10 25321472 578312 Positive_regulation CASP7 CAPN8 15210727 1309796 Positive_regulation CASP7 CAPN8 22281016 1660957 Positive_regulation CASP7 CAPN8 9314540 1463848 Positive_regulation CASP7 CLDN10 22361748 554430 Positive_regulation CASP7 EPHB2 15266324 424738 Positive_regulation CASP7 EPHB2 21037797 2301660 Positive_regulation CASP7 EPHB2 23018309 653353 Positive_regulation CASP7 EPHB2 25013376 1063078 Positive_regulation CASP7 EPHB2 25606044 746829 Positive_regulation CASP7 FAS 10727454 1514592 Positive_regulation CASP7 FAS 11121439 1265821 Positive_regulation CASP7 FAS 11696559 1275993 Positive_regulation CASP7 FAS 12163562 1524374 Positive_regulation CASP7 FAS 12163562 1524470 Positive_regulation CASP7 FAS 12163562 1524501 Positive_regulation CASP7 FAS 14612908 423773 Positive_regulation CASP7 FAS 15857508 365177 Positive_regulation CASP7 FAS 16365167 1326352 Positive_regulation CASP7 FAS 17295922 1651116 Positive_regulation CASP7 FAS 18211685 658890 Positive_regulation CASP7 FAS 21083888 2231212 Positive_regulation CASP7 FAS 21212468 28931 Positive_regulation CASP7 FAS 21477291 527199 Positive_regulation CASP7 FAS 21569413 1723621 Positive_regulation CASP7 FAS 21625644 2525264 Positive_regulation CASP7 FAS 21629700 2525602 Positive_regulation CASP7 FAS 22084408 1566110 Positive_regulation CASP7 FAS 22859258 1086647 Positive_regulation CASP7 FAS 22876188 3058792 Positive_regulation CASP7 FAS 22942738 1097168 Positive_regulation CASP7 FAS 23029562 2698829 Positive_regulation CASP7 FAS 23103563 154191 Positive_regulation CASP7 FAS 23618909 561693 Positive_regulation CASP7 FAS 23633472 2183105 Positive_regulation CASP7 FAS 23787996 548445 Positive_regulation CASP7 FAS 24157880 568621 Positive_regulation CASP7 FAS 24716143 1694463 Positive_regulation CASP7 FAS 25101900 3068802 Positive_regulation CASP7 FAS 25548754 219495 Positive_regulation CASP7 FAS 25594018 2173718 Positive_regulation CASP7 FAS 9730893 1603545 Positive_regulation CASP7 FAS 9730899 1603743 Positive_regulation CASP7 FAS 9730899 1603756 Positive_regulation CASP7 FAS 9730899 1603796 Positive_regulation CASP7 MAP2K6 15266324 424744 Positive_regulation CASP7 MIP 21347304 2503550 Positive_regulation CASP7 MMP28 19547714 1671302 Positive_regulation CASP7 MMP28 20416058 1854332 Positive_regulation CASP7 MMP28 25250578 3009507 Positive_regulation CASP7 MMP28 25250578 3009793 Positive_regulation CASP7 MMP7 19547714 1671317 Positive_regulation CASP7 MMP7 20416058 1854347 Positive_regulation CASP7 MMP7 25250578 3009522 Positive_regulation CASP7 MMP7 25250578 3009808 Positive_regulation CASP7 SPHK1 24572701 652058 Positive_regulation CASP7 TLR7 23762026 3062053 Positive_regulation CASP7 TNF 10727454 1514591 Positive_regulation CASP7 TNF 10839812 1515686 Positive_regulation CASP7 TNF 11381085 1270313 Positive_regulation CASP7 TNF 18625845 1353886 Positive_regulation CASP7 TNF 19440308 2416525 Positive_regulation CASP7 TNF 19440308 2416526 Positive_regulation CASP7 TNF 19440308 2416527 Positive_regulation CASP7 TNF 19440308 2416528 Positive_regulation CASP7 TNF 19440308 2416595 Positive_regulation CASP7 TNF 19440308 2416596 Positive_regulation CASP7 TNF 19440308 2416597 Positive_regulation CASP7 TNF 19440308 2416635 Positive_regulation CASP7 TNF 19440308 2416636 Positive_regulation CASP7 TNF 19440308 2416666 Positive_regulation CASP7 TNF 19440308 2416681 Positive_regulation CASP7 TNF 19440308 2416696 Positive_regulation CASP7 TNF 19440308 2416711 Positive_regulation CASP7 TNF 19440308 2416750 Positive_regulation CASP7 TNF 19440308 2416776 Positive_regulation CASP7 TNF 20200974 1237337 Positive_regulation CASP7 TNF 20200974 1237338 Positive_regulation CASP7 TNF 20200974 1237359 Positive_regulation CASP7 TNF 20693346 716074 Positive_regulation CASP7 TNF 22036896 2176711 Positive_regulation CASP7 TNF 22089168 553467 Positive_regulation CASP7 TNF 22540228 1662230 Positive_regulation CASP7 TNF 22540228 1662244 Positive_regulation CASP7 TNF 22815752 2665965 Positive_regulation CASP7 TNF 22864384 1727529 Positive_regulation CASP7 TNF 23264463 1810457 Positive_regulation CASP7 TNF 23386613 1206374 Positive_regulation CASP7 TNF 23659427 509816 Positive_regulation CASP7 TNF 23816559 625758 Positive_regulation CASP7 TNF 24028654 622246 Positive_regulation CASP7 TNF 24028654 622272 Positive_regulation CASP7 TNF 24327924 1831673 Positive_regulation CASP7 TNF 24484528 856865 Positive_regulation CASP7 TNF 24795644 965004 Positive_regulation CASP7 TNF 25285524 3012411 Positive_regulation CASP7 TNF 9565639 1602737 Positive_regulation CASP7 TNFSF10 19196465 112771 Positive_regulation CASP7 TNFSF10 19421137 2125097 Positive_regulation CASP7 TNFSF10 19547714 1671416 Positive_regulation CASP7 TNFSF10 19549337 1851024 Positive_regulation CASP7 TNFSF10 19820719 8259 Positive_regulation CASP7 TNFSF10 20230625 328668 Positive_regulation CASP7 TNFSF10 20230625 328670 Positive_regulation CASP7 TNFSF10 20398369 1853924 Positive_regulation CASP7 TNFSF10 20442774 2448921 Positive_regulation CASP7 TNFSF10 21368859 550559 Positive_regulation CASP7 TNFSF10 21513580 1861736 Positive_regulation CASP7 TNFSF10 21513580 1861802 Positive_regulation CASP7 TNFSF10 21513580 1861853 Positive_regulation CASP7 TNFSF10 21513580 1861902 Positive_regulation CASP7 TNFSF10 21513580 1861932 Positive_regulation CASP7 TNFSF10 21586138 1862041 Positive_regulation CASP7 TNFSF10 21586138 1862042 Positive_regulation CASP7 TNFSF10 21801359 260646 Positive_regulation CASP7 TNFSF10 21899742 1863338 Positive_regulation CASP7 TNFSF10 22048166 553413 Positive_regulation CASP7 TNFSF10 22174792 2582022 Positive_regulation CASP7 TNFSF10 22213832 1882516 Positive_regulation CASP7 TNFSF10 22613960 1140852 Positive_regulation CASP7 TNFSF10 22619505 1136932 Positive_regulation CASP7 TNFSF10 22662193 2647187 Positive_regulation CASP7 TNFSF10 22860037 2671199 Positive_regulation CASP7 TNFSF10 22876188 3058793 Positive_regulation CASP7 TNFSF10 23348585 559134 Positive_regulation CASP7 TNFSF10 23348588 559156 Positive_regulation CASP7 TNFSF10 23517112 268064 Positive_regulation CASP7 TNFSF10 23818254 781076 Positive_regulation CASP7 TNFSF10 24009855 203899 Positive_regulation CASP7 TNFSF10 24147007 2869114 Positive_regulation CASP7 TNFSF10 24147007 2869136 Positive_regulation CASP7 TNFSF10 24147007 2869152 Positive_regulation CASP7 TNFSF10 24147007 2869168 Positive_regulation CASP7 TNFSF10 24147007 2869190 Positive_regulation CASP7 TNFSF10 24147007 2869203 Positive_regulation CASP7 TNFSF10 24525736 572106 Positive_regulation CASP7 TNFSF10 24525736 572107 Positive_regulation CASP7 TNFSF10 24525736 572108 Positive_regulation CASP7 TNFSF10 24618889 2933415 Positive_regulation CASP7 TNFSF10 24648844 1070659 Positive_regulation CASP7 TNFSF10 24690311 272593 Positive_regulation CASP7 TNFSF10 24745479 474644 Positive_regulation CASP7 TNFSF10 24745479 474645 Positive_regulation CASP7 TNFSF10 24745479 474646 Positive_regulation CASP7 TNFSF10 24745479 474647 Positive_regulation CASP7 TNFSF10 24745479 474648 Positive_regulation CASP7 TNFSF10 24745479 474649 Positive_regulation CASP7 TNFSF10 24745479 474650 Positive_regulation CASP7 TNFSF10 24745479 474651 Positive_regulation CASP7 TNFSF10 24745479 474652 Positive_regulation CASP7 TNFSF10 24745479 474653 Positive_regulation CASP7 TNFSF10 24745479 474694 Positive_regulation CASP7 TNFSF10 24745479 474695 Positive_regulation CASP7 TNFSF10 24745479 474696 Positive_regulation CASP7 TNFSF10 24745479 474697 Positive_regulation CASP7 TNFSF10 24745479 474698 Positive_regulation CASP7 TNFSF10 24745479 474699 Positive_regulation CASP7 TNFSF10 24745479 474700 Positive_regulation CASP7 TNFSF10 24745479 474701 Positive_regulation CASP7 TNFSF10 24745479 474702 Positive_regulation CASP7 TNFSF10 24745479 474703 Positive_regulation CASP7 TNFSF10 24745479 474704 Positive_regulation CASP7 TNFSF10 24745479 474705 Positive_regulation CASP7 TNFSF10 24745479 474706 Positive_regulation CASP7 TNFSF10 24745479 474707 Positive_regulation CASP7 TNFSF10 24745479 474708 Positive_regulation CASP7 TNFSF10 24745479 474709 Positive_regulation CASP7 TNFSF10 24745479 474710 Positive_regulation CASP7 TNFSF10 24745479 474772 Positive_regulation CASP7 TNFSF10 24745479 474773 Positive_regulation CASP7 TNFSF10 24745479 474774 Positive_regulation CASP7 TNFSF10 24745479 474775 Positive_regulation CASP7 TNFSF10 24745479 474776 Positive_regulation CASP7 TNFSF10 24745479 474777 Positive_regulation CASP7 TNFSF10 24745479 474778 Positive_regulation CASP7 TNFSF10 24745479 474779 Positive_regulation CASP7 TNFSF10 24745479 474780 Positive_regulation CASP7 TNFSF10 24745479 474781 Positive_regulation CASP7 TNFSF10 24745479 474782 Positive_regulation CASP7 TNFSF10 24745479 474783 Positive_regulation CASP7 TNFSF10 24745479 474835 Positive_regulation CASP7 TNFSF10 24745479 474836 Positive_regulation CASP7 TNFSF10 24745479 474837 Positive_regulation CASP7 TNFSF10 24745479 474838 Positive_regulation CASP7 TNFSF10 24745479 474839 Positive_regulation CASP7 TNFSF10 24745479 474840 Positive_regulation CASP7 TNFSF10 24745479 474841 Positive_regulation CASP7 TNFSF10 24745479 474842 Positive_regulation CASP7 TNFSF10 24745479 474843 Positive_regulation CASP7 TNFSF10 24745479 474844 Positive_regulation CASP7 TNFSF10 24745479 474845 Positive_regulation CASP7 TNFSF10 24745479 474865 Positive_regulation CASP7 TNFSF10 24745479 474866 Positive_regulation CASP7 TNFSF10 24745479 474867 Positive_regulation CASP7 TNFSF10 24745479 474868 Positive_regulation CASP7 TNFSF10 24745479 474883 Positive_regulation CASP7 TNFSF10 24745479 474884 Positive_regulation CASP7 TNFSF10 24745479 474885 Positive_regulation CASP7 TNFSF10 24745479 474902 Positive_regulation CASP7 TNFSF10 24745479 474903 Positive_regulation CASP7 TNFSF10 24745479 474904 Positive_regulation CASP7 TNFSF10 24745479 474905 Positive_regulation CASP7 TNFSF10 24745479 474906 Positive_regulation CASP7 TNFSF10 24745479 474948 Positive_regulation CASP7 TNFSF10 24745479 474966 Positive_regulation CASP7 TNFSF10 24910845 948147 Positive_regulation CASP7 TNFSF10 25321472 578313 Positive_regulation CASP7 TNFSF10 25398248 1018803 Positive_regulation CASP7 TNFSF10 25398248 1018805 Positive_regulation CASP7 TNFSF10 25398248 1018807 Positive_regulation CASP8 ANGPT1 23554782 1226179 Positive_regulation CASP8 ANGPT1 23554782 1226211 Positive_regulation CASP8 CAPN8 15210727 1309810 Positive_regulation CASP8 CAPN8 22281016 1660971 Positive_regulation CASP8 CAPN8 9314540 1463862 Positive_regulation CASP8 CLDN10 22361748 554455 Positive_regulation CASP8 CLU 25411798 1134561 Positive_regulation CASP8 CLU 25411798 1134565 Positive_regulation CASP8 EPHB2 15266324 424746 Positive_regulation CASP8 EPHB2 21037797 2301661 Positive_regulation CASP8 EPHB2 22564826 159950 Positive_regulation CASP8 EPHB2 23018309 653354 Positive_regulation CASP8 EPHB2 25013376 1063079 Positive_regulation CASP8 EPHB2 25606044 746831 Positive_regulation CASP8 FAS 10579724 1253157 Positive_regulation CASP8 FAS 10601363 1513776 Positive_regulation CASP8 FAS 10727454 1514594 Positive_regulation CASP8 FAS 11121439 1265822 Positive_regulation CASP8 FAS 11157988 1267371 Positive_regulation CASP8 FAS 11181697 1518437 Positive_regulation CASP8 FAS 11208865 1518752 Positive_regulation CASP8 FAS 11696559 1275995 Positive_regulation CASP8 FAS 11818026 380681 Positive_regulation CASP8 FAS 11980919 1282260 Positive_regulation CASP8 FAS 12163562 1524375 Positive_regulation CASP8 FAS 12163562 1524376 Positive_regulation CASP8 FAS 12163562 1524377 Positive_regulation CASP8 FAS 12163562 1524403 Positive_regulation CASP8 FAS 12163562 1524471 Positive_regulation CASP8 FAS 12163562 1524502 Positive_regulation CASP8 FAS 12495445 656277 Positive_regulation CASP8 FAS 14612908 423774 Positive_regulation CASP8 FAS 14960210 656461 Positive_regulation CASP8 FAS 15795317 1319322 Positive_regulation CASP8 FAS 15795317 1319357 Positive_regulation CASP8 FAS 15857508 365178 Positive_regulation CASP8 FAS 16009715 1536896 Positive_regulation CASP8 FAS 16009715 1536897 Positive_regulation CASP8 FAS 16009715 1536902 Positive_regulation CASP8 FAS 16129703 1537085 Positive_regulation CASP8 FAS 16365167 1326353 Positive_regulation CASP8 FAS 17295922 1651118 Positive_regulation CASP8 FAS 18190721 1646128 Positive_regulation CASP8 FAS 18725521 1551761 Positive_regulation CASP8 FAS 18769617 2396030 Positive_regulation CASP8 FAS 18925930 659067 Positive_regulation CASP8 FAS 19171757 1363631 Positive_regulation CASP8 FAS 19582140 2370432 Positive_regulation CASP8 FAS 19689281 681831 Positive_regulation CASP8 FAS 19876397 2429974 Positive_regulation CASP8 FAS 19936090 981590 Positive_regulation CASP8 FAS 20358022 35592 Positive_regulation CASP8 FAS 20953353 1748383 Positive_regulation CASP8 FAS 21083888 2231215 Positive_regulation CASP8 FAS 21118483 403464 Positive_regulation CASP8 FAS 21151158 12237 Positive_regulation CASP8 FAS 21212468 28932 Positive_regulation CASP8 FAS 21331282 934776 Positive_regulation CASP8 FAS 21368876 550936 Positive_regulation CASP8 FAS 21368876 550937 Positive_regulation CASP8 FAS 21477291 527200 Positive_regulation CASP8 FAS 21569413 1723623 Positive_regulation CASP8 FAS 21625644 2525265 Positive_regulation CASP8 FAS 21629700 2525603 Positive_regulation CASP8 FAS 21670490 2176159 Positive_regulation CASP8 FAS 21738161 1961547 Positive_regulation CASP8 FAS 21760870 2220406 Positive_regulation CASP8 FAS 22047640 1626432 Positive_regulation CASP8 FAS 22084408 1566112 Positive_regulation CASP8 FAS 22135505 3128234 Positive_regulation CASP8 FAS 22190004 553792 Positive_regulation CASP8 FAS 22272214 813686 Positive_regulation CASP8 FAS 22348197 497086 Positive_regulation CASP8 FAS 22507896 799385 Positive_regulation CASP8 FAS 22675349 1073057 Positive_regulation CASP8 FAS 22859258 1086648 Positive_regulation CASP8 FAS 22876188 3058794 Positive_regulation CASP8 FAS 22904669 1060594 Positive_regulation CASP8 FAS 22942738 1097170 Positive_regulation CASP8 FAS 22963678 1231246 Positive_regulation CASP8 FAS 22978358 3215095 Positive_regulation CASP8 FAS 23029562 2698830 Positive_regulation CASP8 FAS 23103563 154192 Positive_regulation CASP8 FAS 23181119 842718 Positive_regulation CASP8 FAS 23256595 3215199 Positive_regulation CASP8 FAS 23372841 2746219 Positive_regulation CASP8 FAS 23409788 410053 Positive_regulation CASP8 FAS 23468852 2759832 Positive_regulation CASP8 FAS 23470450 2117227 Positive_regulation CASP8 FAS 23554804 1226298 Positive_regulation CASP8 FAS 23618909 561694 Positive_regulation CASP8 FAS 23633472 2183106 Positive_regulation CASP8 FAS 23675144 1064520 Positive_regulation CASP8 FAS 23687616 3165308 Positive_regulation CASP8 FAS 23787996 548446 Positive_regulation CASP8 FAS 23935974 2828781 Positive_regulation CASP8 FAS 23983679 696932 Positive_regulation CASP8 FAS 24115947 909165 Positive_regulation CASP8 FAS 24148892 412480 Positive_regulation CASP8 FAS 24148892 412485 Positive_regulation CASP8 FAS 24157880 568622 Positive_regulation CASP8 FAS 24434519 570983 Positive_regulation CASP8 FAS 24434519 570984 Positive_regulation CASP8 FAS 24578682 938691 Positive_regulation CASP8 FAS 24603338 572766 Positive_regulation CASP8 FAS 24622841 3081749 Positive_regulation CASP8 FAS 24716143 1694465 Positive_regulation CASP8 FAS 24949464 192764 Positive_regulation CASP8 FAS 24980819 2194710 Positive_regulation CASP8 FAS 25072848 2993054 Positive_regulation CASP8 FAS 25548754 219496 Positive_regulation CASP8 FAS 25594018 2173719 Positive_regulation CASP8 FAS 9128256 1459891 Positive_regulation CASP8 FAS 9206994 1601252 Positive_regulation CASP8 FAS 9730893 1603546 Positive_regulation CASP8 FAS 9730899 1603744 Positive_regulation CASP8 FAS 9730899 1603757 Positive_regulation CASP8 FAS 9730899 1603797 Positive_regulation CASP8 ISM2 21544092 551887 Positive_regulation CASP8 MAP2K6 15266324 424752 Positive_regulation CASP8 MIP 21347304 2503551 Positive_regulation CASP8 MMP28 19547714 1671324 Positive_regulation CASP8 MMP28 20416058 1854355 Positive_regulation CASP8 MMP28 23752353 1729808 Positive_regulation CASP8 MMP28 24324518 824469 Positive_regulation CASP8 MMP28 24705500 1730609 Positive_regulation CASP8 MMP28 25250578 3009529 Positive_regulation CASP8 MMP28 25250578 3009815 Positive_regulation CASP8 MMP7 19547714 1671339 Positive_regulation CASP8 MMP7 20416058 1854370 Positive_regulation CASP8 MMP7 23752353 1729824 Positive_regulation CASP8 MMP7 24324518 824484 Positive_regulation CASP8 MMP7 24705500 1730624 Positive_regulation CASP8 MMP7 25250578 3009544 Positive_regulation CASP8 MMP7 25250578 3009830 Positive_regulation CASP8 PLAT 21291561 1891921 Positive_regulation CASP8 SPHK1 24572701 652059 Positive_regulation CASP8 TCN1 23936501 2831132 Positive_regulation CASP8 TLR7 23386613 1206394 Positive_regulation CASP8 TLR7 23762026 3062063 Positive_regulation CASP8 TNF 10727454 1514593 Positive_regulation CASP8 TNF 10839812 1515687 Positive_regulation CASP8 TNF 11381085 1270314 Positive_regulation CASP8 TNF 11696595 1521628 Positive_regulation CASP8 TNF 15138489 424516 Positive_regulation CASP8 TNF 15663790 3104261 Positive_regulation CASP8 TNF 16518473 3039119 Positive_regulation CASP8 TNF 18625845 1353887 Positive_regulation CASP8 TNF 18638380 1722733 Positive_regulation CASP8 TNF 18638380 1722742 Positive_regulation CASP8 TNF 18638380 1722744 Positive_regulation CASP8 TNF 19060883 1983101 Positive_regulation CASP8 TNF 19151749 2124336 Positive_regulation CASP8 TNF 19440308 2416529 Positive_regulation CASP8 TNF 19440308 2416530 Positive_regulation CASP8 TNF 19440308 2416531 Positive_regulation CASP8 TNF 19440308 2416532 Positive_regulation CASP8 TNF 19440308 2416598 Positive_regulation CASP8 TNF 19440308 2416599 Positive_regulation CASP8 TNF 19440308 2416637 Positive_regulation CASP8 TNF 19440308 2416638 Positive_regulation CASP8 TNF 19440308 2416667 Positive_regulation CASP8 TNF 19440308 2416682 Positive_regulation CASP8 TNF 19440308 2416697 Positive_regulation CASP8 TNF 19440308 2416712 Positive_regulation CASP8 TNF 19440308 2416751 Positive_regulation CASP8 TNF 19440308 2416777 Positive_regulation CASP8 TNF 19444304 487421 Positive_regulation CASP8 TNF 19689281 681830 Positive_regulation CASP8 TNF 19818125 3091170 Positive_regulation CASP8 TNF 20089176 283992 Positive_regulation CASP8 TNF 20200974 1237339 Positive_regulation CASP8 TNF 20920299 481704 Positive_regulation CASP8 TNF 20920299 481708 Positive_regulation CASP8 TNF 21103379 2483895 Positive_regulation CASP8 TNF 21307340 1786592 Positive_regulation CASP8 TNF 21368763 1987127 Positive_regulation CASP8 TNF 22036896 2176712 Positive_regulation CASP8 TNF 22089168 553468 Positive_regulation CASP8 TNF 22089168 553477 Positive_regulation CASP8 TNF 22101767 1961795 Positive_regulation CASP8 TNF 22101767 1961797 Positive_regulation CASP8 TNF 22297296 554124 Positive_regulation CASP8 TNF 22297296 554139 Positive_regulation CASP8 TNF 22297296 554140 Positive_regulation CASP8 TNF 22432009 2611568 Positive_regulation CASP8 TNF 22540228 1662231 Positive_regulation CASP8 TNF 22540228 1662232 Positive_regulation CASP8 TNF 22540228 1662245 Positive_regulation CASP8 TNF 22540228 1662250 Positive_regulation CASP8 TNF 22540228 1662252 Positive_regulation CASP8 TNF 22681760 264872 Positive_regulation CASP8 TNF 22768286 2660444 Positive_regulation CASP8 TNF 22864384 1727530 Positive_regulation CASP8 TNF 22973518 1079325 Positive_regulation CASP8 TNF 23193206 729931 Positive_regulation CASP8 TNF 23264463 1810416 Positive_regulation CASP8 TNF 23264463 1810428 Positive_regulation CASP8 TNF 23264463 1810429 Positive_regulation CASP8 TNF 23264463 1810458 Positive_regulation CASP8 TNF 23328672 559013 Positive_regulation CASP8 TNF 23328672 559030 Positive_regulation CASP8 TNF 23328672 559038 Positive_regulation CASP8 TNF 23386613 1206375 Positive_regulation CASP8 TNF 23386613 1206402 Positive_regulation CASP8 TNF 23527236 2770243 Positive_regulation CASP8 TNF 23630447 1061372 Positive_regulation CASP8 TNF 23659427 509817 Positive_regulation CASP8 TNF 23816559 625759 Positive_regulation CASP8 TNF 23828575 563890 Positive_regulation CASP8 TNF 23915963 1733937 Positive_regulation CASP8 TNF 24025841 1990953 Positive_regulation CASP8 TNF 24028654 622247 Positive_regulation CASP8 TNF 24028654 622273 Positive_regulation CASP8 TNF 24058525 2847790 Positive_regulation CASP8 TNF 24068862 1916346 Positive_regulation CASP8 TNF 24434519 570982 Positive_regulation CASP8 TNF 24535827 1416579 Positive_regulation CASP8 TNF 24554039 453633 Positive_regulation CASP8 TNF 24772178 825594 Positive_regulation CASP8 TNF 24795644 964969 Positive_regulation CASP8 TNF 24795644 965005 Positive_regulation CASP8 TNF 24949464 192763 Positive_regulation CASP8 TNF 25053988 986906 Positive_regulation CASP8 TNF 25053988 986908 Positive_regulation CASP8 TNF 25071782 913471 Positive_regulation CASP8 TNF 25216531 2199939 Positive_regulation CASP8 TNF 25285524 3012412 Positive_regulation CASP8 TNF 25328816 1243421 Positive_regulation CASP8 TNF 25431611 827034 Positive_regulation CASP8 TNF 25443632 762684 Positive_regulation CASP8 TNF 25443632 762688 Positive_regulation CASP8 TNF 25443632 762698 Positive_regulation CASP8 TNF 9128256 1459890 Positive_regulation CASP8 TNF 9565639 1602738 Positive_regulation CASP8 TNFSF10 12644829 422440 Positive_regulation CASP8 TNFSF10 12697056 365140 Positive_regulation CASP8 TNFSF10 12771998 422659 Positive_regulation CASP8 TNFSF10 16434995 426973 Positive_regulation CASP8 TNFSF10 17118156 384174 Positive_regulation CASP8 TNFSF10 17177999 480411 Positive_regulation CASP8 TNFSF10 17718901 1645695 Positive_regulation CASP8 TNFSF10 18590557 1848987 Positive_regulation CASP8 TNFSF10 19229339 2405966 Positive_regulation CASP8 TNFSF10 19421137 2125098 Positive_regulation CASP8 TNFSF10 19547714 1671417 Positive_regulation CASP8 TNFSF10 19549337 1851025 Positive_regulation CASP8 TNFSF10 19668227 2126282 Positive_regulation CASP8 TNFSF10 19820719 8260 Positive_regulation CASP8 TNFSF10 20003459 1852649 Positive_regulation CASP8 TNFSF10 20003459 1852667 Positive_regulation CASP8 TNFSF10 20062539 2436809 Positive_regulation CASP8 TNFSF10 20157422 1676826 Positive_regulation CASP8 TNFSF10 20308427 1373768 Positive_regulation CASP8 TNFSF10 20442774 2448922 Positive_regulation CASP8 TNFSF10 20646307 256699 Positive_regulation CASP8 TNFSF10 20646307 256716 Positive_regulation CASP8 TNFSF10 20661217 2133102 Positive_regulation CASP8 TNFSF10 20661477 2456806 Positive_regulation CASP8 TNFSF10 21092294 1860274 Positive_regulation CASP8 TNFSF10 21368859 550567 Positive_regulation CASP8 TNFSF10 21368884 551048 Positive_regulation CASP8 TNFSF10 21513580 1861738 Positive_regulation CASP8 TNFSF10 21513580 1861804 Positive_regulation CASP8 TNFSF10 21513580 1861856 Positive_regulation CASP8 TNFSF10 21513580 1861903 Positive_regulation CASP8 TNFSF10 21513580 1861935 Positive_regulation CASP8 TNFSF10 21513580 1861936 Positive_regulation CASP8 TNFSF10 21586138 1862044 Positive_regulation CASP8 TNFSF10 21586138 1862045 Positive_regulation CASP8 TNFSF10 21586138 1862046 Positive_regulation CASP8 TNFSF10 21586138 1862082 Positive_regulation CASP8 TNFSF10 21586138 1862087 Positive_regulation CASP8 TNFSF10 21687633 2528730 Positive_regulation CASP8 TNFSF10 21756247 3093062 Positive_regulation CASP8 TNFSF10 21789791 2176288 Positive_regulation CASP8 TNFSF10 21801359 260647 Positive_regulation CASP8 TNFSF10 21801359 260668 Positive_regulation CASP8 TNFSF10 21801359 260669 Positive_regulation CASP8 TNFSF10 21858177 2546815 Positive_regulation CASP8 TNFSF10 21899742 1863340 Positive_regulation CASP8 TNFSF10 21931726 2554267 Positive_regulation CASP8 TNFSF10 22048166 553414 Positive_regulation CASP8 TNFSF10 22174792 2582024 Positive_regulation CASP8 TNFSF10 22213832 1882517 Positive_regulation CASP8 TNFSF10 22435755 288448 Positive_regulation CASP8 TNFSF10 22448764 532653 Positive_regulation CASP8 TNFSF10 22619505 1136934 Positive_regulation CASP8 TNFSF10 22662193 2647188 Positive_regulation CASP8 TNFSF10 22681760 264873 Positive_regulation CASP8 TNFSF10 22735465 1140943 Positive_regulation CASP8 TNFSF10 22860037 2671200 Positive_regulation CASP8 TNFSF10 22876188 3058795 Positive_regulation CASP8 TNFSF10 22928011 2681314 Positive_regulation CASP8 TNFSF10 22932446 834909 Positive_regulation CASP8 TNFSF10 22932446 834913 Positive_regulation CASP8 TNFSF10 22942679 1096707 Positive_regulation CASP8 TNFSF10 23018355 1735708 Positive_regulation CASP8 TNFSF10 23096115 557880 Positive_regulation CASP8 TNFSF10 23239672 162666 Positive_regulation CASP8 TNFSF10 23254292 558419 Positive_regulation CASP8 TNFSF10 23254292 558420 Positive_regulation CASP8 TNFSF10 23289871 411590 Positive_regulation CASP8 TNFSF10 23300075 1206089 Positive_regulation CASP8 TNFSF10 23341781 2341460 Positive_regulation CASP8 TNFSF10 23348585 559123 Positive_regulation CASP8 TNFSF10 23348585 559135 Positive_regulation CASP8 TNFSF10 23348588 559157 Positive_regulation CASP8 TNFSF10 23348588 559158 Positive_regulation CASP8 TNFSF10 23348588 559159 Positive_regulation CASP8 TNFSF10 23348588 559160 Positive_regulation CASP8 TNFSF10 23348588 559180 Positive_regulation CASP8 TNFSF10 23348588 559181 Positive_regulation CASP8 TNFSF10 23348591 559340 Positive_regulation CASP8 TNFSF10 23348591 559341 Positive_regulation CASP8 TNFSF10 23365613 817255 Positive_regulation CASP8 TNFSF10 23370279 559380 Positive_regulation CASP8 TNFSF10 23409788 410093 Positive_regulation CASP8 TNFSF10 23429289 560241 Positive_regulation CASP8 TNFSF10 23432760 267888 Positive_regulation CASP8 TNFSF10 23441146 2756919 Positive_regulation CASP8 TNFSF10 23470485 2182451 Positive_regulation CASP8 TNFSF10 23470485 2182452 Positive_regulation CASP8 TNFSF10 23517112 268065 Positive_regulation CASP8 TNFSF10 23533482 817813 Positive_regulation CASP8 TNFSF10 23573148 818509 Positive_regulation CASP8 TNFSF10 23696862 2795599 Positive_regulation CASP8 TNFSF10 23703388 561930 Positive_regulation CASP8 TNFSF10 23703388 561936 Positive_regulation CASP8 TNFSF10 23703388 561945 Positive_regulation CASP8 TNFSF10 23818254 781077 Positive_regulation CASP8 TNFSF10 23874836 2823225 Positive_regulation CASP8 TNFSF10 24009855 203900 Positive_regulation CASP8 TNFSF10 24009855 203904 Positive_regulation CASP8 TNFSF10 24034452 399403 Positive_regulation CASP8 TNFSF10 24113173 567638 Positive_regulation CASP8 TNFSF10 24147007 2869104 Positive_regulation CASP8 TNFSF10 24147007 2869105 Positive_regulation CASP8 TNFSF10 24147007 2869115 Positive_regulation CASP8 TNFSF10 24147007 2869137 Positive_regulation CASP8 TNFSF10 24147007 2869153 Positive_regulation CASP8 TNFSF10 24147007 2869154 Positive_regulation CASP8 TNFSF10 24147007 2869169 Positive_regulation CASP8 TNFSF10 24147007 2869191 Positive_regulation CASP8 TNFSF10 24147007 2869204 Positive_regulation CASP8 TNFSF10 24287696 569420 Positive_regulation CASP8 TNFSF10 24287696 569436 Positive_regulation CASP8 TNFSF10 24287696 569442 Positive_regulation CASP8 TNFSF10 24369016 185971 Positive_regulation CASP8 TNFSF10 24392356 864787 Positive_regulation CASP8 TNFSF10 24525736 572109 Positive_regulation CASP8 TNFSF10 24603337 572761 Positive_regulation CASP8 TNFSF10 24610963 3709 Positive_regulation CASP8 TNFSF10 24610963 3711 Positive_regulation CASP8 TNFSF10 24618889 2933416 Positive_regulation CASP8 TNFSF10 24627686 1070437 Positive_regulation CASP8 TNFSF10 24648844 1070660 Positive_regulation CASP8 TNFSF10 24667731 2939091 Positive_regulation CASP8 TNFSF10 24690311 272530 Positive_regulation CASP8 TNFSF10 24690311 272531 Positive_regulation CASP8 TNFSF10 24690311 272532 Positive_regulation CASP8 TNFSF10 24690311 272533 Positive_regulation CASP8 TNFSF10 24690311 272557 Positive_regulation CASP8 TNFSF10 24690311 272594 Positive_regulation CASP8 TNFSF10 24690311 272595 Positive_regulation CASP8 TNFSF10 24690311 272602 Positive_regulation CASP8 TNFSF10 24709704 617063 Positive_regulation CASP8 TNFSF10 24745479 474654 Positive_regulation CASP8 TNFSF10 24745479 474655 Positive_regulation CASP8 TNFSF10 24745479 474656 Positive_regulation CASP8 TNFSF10 24745479 474657 Positive_regulation CASP8 TNFSF10 24745479 474711 Positive_regulation CASP8 TNFSF10 24745479 474712 Positive_regulation CASP8 TNFSF10 24745479 474713 Positive_regulation CASP8 TNFSF10 24745479 474714 Positive_regulation CASP8 TNFSF10 24745479 474715 Positive_regulation CASP8 TNFSF10 24745479 474716 Positive_regulation CASP8 TNFSF10 24745479 474785 Positive_regulation CASP8 TNFSF10 24745479 474786 Positive_regulation CASP8 TNFSF10 24745479 474787 Positive_regulation CASP8 TNFSF10 24745479 474848 Positive_regulation CASP8 TNFSF10 24745479 474849 Positive_regulation CASP8 TNFSF10 24745479 474869 Positive_regulation CASP8 TNFSF10 24745479 474870 Positive_regulation CASP8 TNFSF10 24745479 474871 Positive_regulation CASP8 TNFSF10 24745479 474872 Positive_regulation CASP8 TNFSF10 24745479 474886 Positive_regulation CASP8 TNFSF10 24745479 474907 Positive_regulation CASP8 TNFSF10 24823879 1126637 Positive_regulation CASP8 TNFSF10 24910845 948141 Positive_regulation CASP8 TNFSF10 24927176 2980174 Positive_regulation CASP8 TNFSF10 24995146 3151743 Positive_regulation CASP8 TNFSF10 25015549 2195777 Positive_regulation CASP8 TNFSF10 25259715 3010541 Positive_regulation CASP8 TNFSF10 25321472 578327 Positive_regulation CASP8 TNFSF10 25321472 578348 Positive_regulation CASP8 TNFSF10 PMC2243052 1475548 Positive_regulation CASP8 TP63 20429941 328921 Positive_regulation CASP9 CAPN8 15210727 1309824 Positive_regulation CASP9 CAPN8 22252275 1230179 Positive_regulation CASP9 CAPN8 22281016 1660985 Positive_regulation CASP9 CAPN8 25121098 196560 Positive_regulation CASP9 CAPN8 9314540 1463876 Positive_regulation CASP9 CCND1 25105148 196080 Positive_regulation CASP9 CLDN10 22361748 554480 Positive_regulation CASP9 EPHB2 15266324 424754 Positive_regulation CASP9 EPHB2 21037797 2301662 Positive_regulation CASP9 EPHB2 21219631 258377 Positive_regulation CASP9 EPHB2 21219631 258384 Positive_regulation CASP9 EPHB2 23018309 653355 Positive_regulation CASP9 EPHB2 23961994 1700240 Positive_regulation CASP9 EPHB2 25013376 1063080 Positive_regulation CASP9 EPHB2 25606044 746833 Positive_regulation CASP9 FAS 10727454 1514596 Positive_regulation CASP9 FAS 11121439 1265823 Positive_regulation CASP9 FAS 11696559 1275997 Positive_regulation CASP9 FAS 12163562 1524378 Positive_regulation CASP9 FAS 12163562 1524472 Positive_regulation CASP9 FAS 12163562 1524503 Positive_regulation CASP9 FAS 14612908 423775 Positive_regulation CASP9 FAS 15857508 365179 Positive_regulation CASP9 FAS 16365167 1326354 Positive_regulation CASP9 FAS 17295922 1651120 Positive_regulation CASP9 FAS 21083888 2231218 Positive_regulation CASP9 FAS 21212468 28933 Positive_regulation CASP9 FAS 21477291 527201 Positive_regulation CASP9 FAS 21569413 1723625 Positive_regulation CASP9 FAS 21625644 2525266 Positive_regulation CASP9 FAS 21629700 2525604 Positive_regulation CASP9 FAS 22084408 1566114 Positive_regulation CASP9 FAS 22272214 813689 Positive_regulation CASP9 FAS 22859258 1086649 Positive_regulation CASP9 FAS 22876188 3058796 Positive_regulation CASP9 FAS 22942738 1097172 Positive_regulation CASP9 FAS 23029562 2698832 Positive_regulation CASP9 FAS 23470450 2117228 Positive_regulation CASP9 FAS 23618909 561695 Positive_regulation CASP9 FAS 23633472 2183107 Positive_regulation CASP9 FAS 23787996 548447 Positive_regulation CASP9 FAS 24157880 568623 Positive_regulation CASP9 FAS 24716143 1694467 Positive_regulation CASP9 FAS 25072848 2993055 Positive_regulation CASP9 FAS 25548754 219497 Positive_regulation CASP9 FAS 25594018 2173720 Positive_regulation CASP9 FAS 9730893 1603547 Positive_regulation CASP9 FAS 9730899 1603745 Positive_regulation CASP9 FAS 9730899 1603772 Positive_regulation CASP9 FAS 9730899 1603798 Positive_regulation CASP9 FOXO1 23610600 2115286 Positive_regulation CASP9 MAP2K6 15266324 424760 Positive_regulation CASP9 MIP 21347304 2503552 Positive_regulation CASP9 MMP28 18629305 793093 Positive_regulation CASP9 MMP28 19547714 1671346 Positive_regulation CASP9 MMP28 19966836 8535 Positive_regulation CASP9 MMP28 20416058 1854378 Positive_regulation CASP9 MMP28 23752353 1729831 Positive_regulation CASP9 MMP28 24705500 1730631 Positive_regulation CASP9 MMP28 25250578 3009551 Positive_regulation CASP9 MMP28 25250578 3009837 Positive_regulation CASP9 MMP28 PMC3871853 1136428 Positive_regulation CASP9 MMP7 18629305 793108 Positive_regulation CASP9 MMP7 19547714 1671361 Positive_regulation CASP9 MMP7 19966836 8550 Positive_regulation CASP9 MMP7 20416058 1854393 Positive_regulation CASP9 MMP7 23752353 1729847 Positive_regulation CASP9 MMP7 24705500 1730646 Positive_regulation CASP9 MMP7 25250578 3009566 Positive_regulation CASP9 MMP7 25250578 3009852 Positive_regulation CASP9 MMP7 PMC3871853 1136443 Positive_regulation CASP9 SPHK1 24572701 652060 Positive_regulation CASP9 TLR7 23762026 3062073 Positive_regulation CASP9 TNF 10727454 1514595 Positive_regulation CASP9 TNF 10839812 1515688 Positive_regulation CASP9 TNF 11381085 1270315 Positive_regulation CASP9 TNF 18625845 1353888 Positive_regulation CASP9 TNF 19440308 2416533 Positive_regulation CASP9 TNF 19440308 2416534 Positive_regulation CASP9 TNF 19440308 2416535 Positive_regulation CASP9 TNF 19440308 2416536 Positive_regulation CASP9 TNF 19440308 2416600 Positive_regulation CASP9 TNF 19440308 2416601 Positive_regulation CASP9 TNF 19440308 2416639 Positive_regulation CASP9 TNF 19440308 2416640 Positive_regulation CASP9 TNF 19440308 2416668 Positive_regulation CASP9 TNF 19440308 2416683 Positive_regulation CASP9 TNF 19440308 2416698 Positive_regulation CASP9 TNF 19440308 2416713 Positive_regulation CASP9 TNF 19440308 2416752 Positive_regulation CASP9 TNF 19440308 2416778 Positive_regulation CASP9 TNF 20200974 1237340 Positive_regulation CASP9 TNF 21858054 2545934 Positive_regulation CASP9 TNF 22036896 2176713 Positive_regulation CASP9 TNF 22089168 553469 Positive_regulation CASP9 TNF 22540228 1662233 Positive_regulation CASP9 TNF 22540228 1662246 Positive_regulation CASP9 TNF 22864384 1727531 Positive_regulation CASP9 TNF 23193206 729933 Positive_regulation CASP9 TNF 23264463 1810459 Positive_regulation CASP9 TNF 23386613 1206376 Positive_regulation CASP9 TNF 23659427 509818 Positive_regulation CASP9 TNF 23816559 625760 Positive_regulation CASP9 TNF 24028654 622248 Positive_regulation CASP9 TNF 24028654 622274 Positive_regulation CASP9 TNF 24734070 1149649 Positive_regulation CASP9 TNF 24795644 965006 Positive_regulation CASP9 TNF 25216531 2199941 Positive_regulation CASP9 TNF 25285524 3012413 Positive_regulation CASP9 TNF 9565639 1602739 Positive_regulation CASP9 TNFSF10 19421137 2125099 Positive_regulation CASP9 TNFSF10 19547714 1671419 Positive_regulation CASP9 TNFSF10 19549337 1851026 Positive_regulation CASP9 TNFSF10 19820719 8261 Positive_regulation CASP9 TNFSF10 20442774 2448923 Positive_regulation CASP9 TNFSF10 20661477 2456807 Positive_regulation CASP9 TNFSF10 21368859 550575 Positive_regulation CASP9 TNFSF10 21513580 1861743 Positive_regulation CASP9 TNFSF10 21513580 1861806 Positive_regulation CASP9 TNFSF10 21513580 1861859 Positive_regulation CASP9 TNFSF10 21513580 1861904 Positive_regulation CASP9 TNFSF10 21513580 1861939 Positive_regulation CASP9 TNFSF10 21586138 1862048 Positive_regulation CASP9 TNFSF10 21586138 1862049 Positive_regulation CASP9 TNFSF10 21801359 260648 Positive_regulation CASP9 TNFSF10 21899742 1863342 Positive_regulation CASP9 TNFSF10 22048166 553415 Positive_regulation CASP9 TNFSF10 22174792 2582026 Positive_regulation CASP9 TNFSF10 22213832 1882518 Positive_regulation CASP9 TNFSF10 22619505 1136936 Positive_regulation CASP9 TNFSF10 22662193 2647189 Positive_regulation CASP9 TNFSF10 22860037 2671201 Positive_regulation CASP9 TNFSF10 22876188 3058797 Positive_regulation CASP9 TNFSF10 23091403 3129156 Positive_regulation CASP9 TNFSF10 23289871 411591 Positive_regulation CASP9 TNFSF10 23348585 559124 Positive_regulation CASP9 TNFSF10 23348585 559136 Positive_regulation CASP9 TNFSF10 23348588 559161 Positive_regulation CASP9 TNFSF10 23517112 268066 Positive_regulation CASP9 TNFSF10 23818254 781078 Positive_regulation CASP9 TNFSF10 24009855 203901 Positive_regulation CASP9 TNFSF10 24147007 2869116 Positive_regulation CASP9 TNFSF10 24147007 2869138 Positive_regulation CASP9 TNFSF10 24147007 2869155 Positive_regulation CASP9 TNFSF10 24147007 2869170 Positive_regulation CASP9 TNFSF10 24147007 2869192 Positive_regulation CASP9 TNFSF10 24147007 2869205 Positive_regulation CASP9 TNFSF10 24525736 572110 Positive_regulation CASP9 TNFSF10 24603337 572756 Positive_regulation CASP9 TNFSF10 24618889 2933417 Positive_regulation CASP9 TNFSF10 24648844 1070661 Positive_regulation CASP9 TNFSF10 24690311 272596 Positive_regulation CASP9 TNFSF10 24745479 474658 Positive_regulation CASP9 TNFSF10 24745479 474719 Positive_regulation CASP9 TNFSF10 24745479 474720 Positive_regulation CASP9 TNFSF10 24745479 474721 Positive_regulation CASP9 TNFSF10 24745479 474722 Positive_regulation CASP9 TNFSF10 24745479 474788 Positive_regulation CASP9 TNFSF10 24745479 474789 Positive_regulation CASP9 TNFSF10 24745479 474873 Positive_regulation CASP9 TNFSF10 24745479 474874 Positive_regulation CASP9 TNFSF10 24745479 474908 Positive_regulation CASP9 TNFSF10 25321472 578328 Positive_regulation CASP9 TNFSF10 25321472 578349 Positive_regulation CASP9 TNFSF10 25349561 1147454 Positive_regulation CASP9 TP63 20429941 328896 Positive_regulation CAST CAPN8 18706097 291399 Positive_regulation CAST CAPN8 22615919 2644306 Positive_regulation CAST CAPN8 22615919 2644323 Positive_regulation CASZ1 NGFR 21490919 2512586 Positive_regulation CAT CCND1 10953010 1262078 Positive_regulation CAT FOXO1 22454632 832691 Positive_regulation CAT FOXO1 23299244 1488930 Positive_regulation CAT FOXO1 23801966 961514 Positive_regulation CAT FOXO1 23950968 2833047 Positive_regulation CAT FOXO1 23950968 2833059 Positive_regulation CAT LBP 25045414 2229608 Positive_regulation CAT LBP 25045414 2229616 Positive_regulation CAT TNF 2109037 1561572 Positive_regulation CAT TNF 2193097 1565445 Positive_regulation CAT TNF 2193097 1565456 Positive_regulation CAV1 CAPN8 24624086 953664 Positive_regulation CAV1 EPHB2 19644556 1146850 Positive_regulation CAV1 EPHB2 23339737 534771 Positive_regulation CAV1 EPHB2 23339737 534780 Positive_regulation CAV1 PGC 24475013 2914587 Positive_regulation CAV1 S100B 20827421 513030 Positive_regulation CAV1 TNF 23383114 2748006 Positive_regulation CBFA2T2 ANGPT1 16157706 1324023 Positive_regulation CBFA2T2 PECAM1 20723025 1692074 Positive_regulation CBL NGFR 22880054 2673840 Positive_regulation CBX4 HBEGF 25033412 2372826 Positive_regulation CBX4 NEDD9 21670214 1389158 Positive_regulation CBX4 ZFP57 20808772 2471930 Positive_regulation CBX4 ZFP57 20808772 2471998 Positive_regulation CBX8 PLAU 22039516 2565741 Positive_regulation CBX8 TNF 22426696 14544 Positive_regulation CBX8 TNF 22426696 14545 Positive_regulation CBX8 TNF 22426696 14570 Positive_regulation CCBL1 LIPG 17497022 3071562 Positive_regulation CCBL2 LIPG 17497022 3071564 Positive_regulation CCDC19 IFI27 24976536 1483654 Positive_regulation CCDC19 IFI27 24976536 1483681 Positive_regulation CCDC88A JAG1 25610519 3225771 Positive_regulation CCDC88A NES 17403694 2027305 Positive_regulation CCK EPHB2 25427253 3030507 Positive_regulation CCK SRGN 21885869 719770 Positive_regulation CCL1 LINC00284 25431574 916609 Positive_regulation CCL1 LINC00341 25431574 916569 Positive_regulation CCL1 TLR7 19057661 3042840 Positive_regulation CCL1 TLR7 25222785 1045963 Positive_regulation CCL11 CCL17 23638129 2787752 Positive_regulation CCL11 TNF 24648846 1156516 Positive_regulation CCL15 MMP28 22147696 1200773 Positive_regulation CCL15 MMP7 22147696 1200788 Positive_regulation CCL17 ANGPT2 24634660 964480 Positive_regulation CCL17 CCL1 24278618 3180316 Positive_regulation CCL17 CCL11 23638129 2787754 Positive_regulation CCL17 CCL13 24278618 3180317 Positive_regulation CCL17 CCL2 24278618 3180318 Positive_regulation CCL17 CCL22 23284739 2730899 Positive_regulation CCL17 CCL24 23638129 2787755 Positive_regulation CCL17 CCL5 23951310 2834155 Positive_regulation CCL17 CCL5 24278618 3180319 Positive_regulation CCL17 CCR1 23951310 2834156 Positive_regulation CCL17 CCR4 23951310 2834157 Positive_regulation CCL17 CCR4 25546419 3036554 Positive_regulation CCL17 CCR5 23951310 2834158 Positive_regulation CCL17 HNRNPF 20049700 774293 Positive_regulation CCL17 HNRNPF 20694020 10660 Positive_regulation CCL17 HNRNPF 23437132 2755715 Positive_regulation CCL17 HNRNPH1 20049700 774294 Positive_regulation CCL17 HNRNPH1 20694020 10661 Positive_regulation CCL17 HNRNPH1 23437132 2755716 Positive_regulation CCL17 IL13 21789181 2537919 Positive_regulation CCL17 IL13 24131304 641134 Positive_regulation CCL17 IL17A 23140447 3113276 Positive_regulation CCL17 IL17A 24049650 1152272 Positive_regulation CCL17 IL2 23140447 3113277 Positive_regulation CCL17 IL22 21789181 2537917 Positive_regulation CCL17 IL33 22566963 900615 Positive_regulation CCL17 IL33 24363657 910287 Positive_regulation CCL17 IL4 23999500 1573550 Positive_regulation CCL17 IL4 23999500 1573564 Positive_regulation CCL17 IL4 24612750 356571 Positive_regulation CCL17 IL4 24646914 1125069 Positive_regulation CCL17 IL6 25136593 197249 Positive_regulation CCL17 PPP3CA 20174570 2313074 Positive_regulation CCL17 PTBP1 20049700 774295 Positive_regulation CCL17 PTBP1 20694020 10662 Positive_regulation CCL17 PTBP1 23437132 2755717 Positive_regulation CCL17 PTBP2 20049700 774292 Positive_regulation CCL17 PTBP2 20694020 10659 Positive_regulation CCL17 PTBP2 23437132 2755713 Positive_regulation CCL17 S100A12 25010197 2987898 Positive_regulation CCL17 STAT5A 23435120 1958566 Positive_regulation CCL17 STAT5A 23435120 1958567 Positive_regulation CCL17 TNF 23140447 3113275 Positive_regulation CCL17 TSLP 23435120 1958522 Positive_regulation CCL17 TSLP 23435120 1958556 Positive_regulation CCL17 TSLP 23437132 2755714 Positive_regulation CCL17 TSLP 24498539 1708761 Positive_regulation CCL17 TSLP 24744755 912163 Positive_regulation CCL17 TSLP 24748808 1162564 Positive_regulation CCL17 TSLP 25400924 1037349 Positive_regulation CCL18 CCL17 23999500 1573561 Positive_regulation CCL18 ITGAL 23999500 1573553 Positive_regulation CCL18 TLR7 25392121 1946644 Positive_regulation CCL18 TNF 16984635 351676 Positive_regulation CCL18 TNF 17875202 109075 Positive_regulation CCL18 TNF 17875202 109076 Positive_regulation CCL18 TNF 17875202 109080 Positive_regulation CCL18 TNF 17875202 109083 Positive_regulation CCL18 TNF 17875202 109087 Positive_regulation CCL18 TNF 17875202 109088 Positive_regulation CCL19 TNF 25473269 743500 Positive_regulation CCL19 TNF 9892622 1605085 Positive_regulation CCL19 TNF 9892622 1605092 Positive_regulation CCL2 ALOX5 24052903 20578 Positive_regulation CCL2 CHI3L1 22056877 2144447 Positive_regulation CCL2 CHI3L1 22056877 2144448 Positive_regulation CCL2 CHI3L1 22056877 2144451 Positive_regulation CCL2 CTGF 22586581 722792 Positive_regulation CCL2 EFNB1 24098442 2856376 Positive_regulation CCL2 EPHB2 21599982 527479 Positive_regulation CCL2 EPHB2 21789185 2537943 Positive_regulation CCL2 EPHB2 21966476 2559069 Positive_regulation CCL2 EPHB2 22736938 1914538 Positive_regulation CCL2 EPHB2 22736938 1914543 Positive_regulation CCL2 EPHB2 22736938 1914544 Positive_regulation CCL2 EPHB2 23216800 2113614 Positive_regulation CCL2 EPHB2 23216800 2113615 Positive_regulation CCL2 EPHB2 23271927 1714631 Positive_regulation CCL2 EPHB2 23349788 2743158 Positive_regulation CCL2 EPHB2 23542035 851005 Positive_regulation CCL2 EPHB2 23542035 851008 Positive_regulation CCL2 EPHB2 24782592 1758329 Positive_regulation CCL2 EPHB2 25166426 3003719 Positive_regulation CCL2 F2R 17480240 279748 Positive_regulation CCL2 F2R 18606855 1551547 Positive_regulation CCL2 F2R 18606855 1551548 Positive_regulation CCL2 F2R 18606855 1551549 Positive_regulation CCL2 F2R 18606855 1551552 Positive_regulation CCL2 F2R 21760880 2535367 Positive_regulation CCL2 F2R 22992722 988771 Positive_regulation CCL2 F2R 23919450 834020 Positive_regulation CCL2 F2R 24015257 2842544 Positive_regulation CCL2 F2R 24385683 1756394 Positive_regulation CCL2 F2R 24475094 2914735 Positive_regulation CCL2 F2R 24475094 2914739 Positive_regulation CCL2 F2R 24624928 511371 Positive_regulation CCL2 F2R 24927773 3102519 Positive_regulation CCL2 F2R 25313362 201342 Positive_regulation CCL2 F2R 8163952 1594360 Positive_regulation CCL2 FAS 16316466 383084 Positive_regulation CCL2 FAS 16316466 383087 Positive_regulation CCL2 FOXO1 24864265 191775 Positive_regulation CCL2 IL1B 20305745 2214361 Positive_regulation CCL2 IL1B 20414371 1215118 Positive_regulation CCL2 IL1B 23717664 2798671 Positive_regulation CCL2 IL1B 23717664 2798672 Positive_regulation CCL2 IL1B 23717664 2798684 Positive_regulation CCL2 IL1B 24489848 2916451 Positive_regulation CCL2 MIP 24381939 186009 Positive_regulation CCL2 MUC16 24101903 962386 Positive_regulation CCL2 PECAM1 22641100 1718340 Positive_regulation CCL2 PECAM1 22641100 1718379 Positive_regulation CCL2 PECAM1 22641100 1718398 Positive_regulation CCL2 PLAT 22425561 1881375 Positive_regulation CCL2 PLAT 22425561 1881376 Positive_regulation CCL2 RGS2 21494556 2513026 Positive_regulation CCL2 S100B 24084731 1113177 Positive_regulation CCL2 S100B PMC4070603 3206022 Positive_regulation CCL2 SMN2 22669976 1203484 Positive_regulation CCL2 SMN2 22669976 1203617 Positive_regulation CCL2 SMN2 22669976 1203636 Positive_regulation CCL2 STAT4 23542035 851038 Positive_regulation CCL2 TLR7 19047436 1552959 Positive_regulation CCL2 TLR7 19461888 3043871 Positive_regulation CCL2 TLR7 22218715 1885956 Positive_regulation CCL2 TLR7 22218715 1885977 Positive_regulation CCL2 TLR7 22692455 1918909 Positive_regulation CCL2 TLR7 23028609 2691847 Positive_regulation CCL2 TLR7 23049242 1224895 Positive_regulation CCL2 TLR7 23762283 2802879 Positive_regulation CCL2 TLR7 25070035 1875941 Positive_regulation CCL2 TLR7 25071732 926917 Positive_regulation CCL2 TLR7 25071732 926918 Positive_regulation CCL2 TLR7 25541965 3035922 Positive_regulation CCL2 TLR7 PMC4085409 661232 Positive_regulation CCL2 TLR7 PMC4085409 661242 Positive_regulation CCL2 TNF 11560995 1520924 Positive_regulation CCL2 TNF 14641910 317000 Positive_regulation CCL2 TNF 14641910 317001 Positive_regulation CCL2 TNF 15631627 3104183 Positive_regulation CCL2 TNF 16033640 3105161 Positive_regulation CCL2 TNF 16091136 3105632 Positive_regulation CCL2 TNF 16259055 3230766 Positive_regulation CCL2 TNF 16277688 104757 Positive_regulation CCL2 TNF 16316466 383086 Positive_regulation CCL2 TNF 16356198 104892 Positive_regulation CCL2 TNF 16356198 104901 Positive_regulation CCL2 TNF 17242164 1544197 Positive_regulation CCL2 TNF 18053220 3108721 Positive_regulation CCL2 TNF 18410682 110363 Positive_regulation CCL2 TNF 18410682 110367 Positive_regulation CCL2 TNF 18410682 110460 Positive_regulation CCL2 TNF 18472920 1743145 Positive_regulation CCL2 TNF 18472920 1743146 Positive_regulation CCL2 TNF 18472920 1743147 Positive_regulation CCL2 TNF 18472920 1743151 Positive_regulation CCL2 TNF 18475720 1745581 Positive_regulation CCL2 TNF 18558008 323722 Positive_regulation CCL2 TNF 18670628 3041678 Positive_regulation CCL2 TNF 18718021 2112416 Positive_regulation CCL2 TNF 19014446 1655593 Positive_regulation CCL2 TNF 1911209 431526 Positive_regulation CCL2 TNF 19116667 2404028 Positive_regulation CCL2 TNF 19132133 3074845 Positive_regulation CCL2 TNF 19351711 708227 Positive_regulation CCL2 TNF 19419583 252602 Positive_regulation CCL2 TNF 19513280 1491886 Positive_regulation CCL2 TNF 19668438 649343 Positive_regulation CCL2 TNF 19736220 811447 Positive_regulation CCL2 TNF 19736220 811450 Positive_regulation CCL2 TNF 19889233 3097638 Positive_regulation CCL2 TNF 20069129 1213489 Positive_regulation CCL2 TNF 20069129 1213495 Positive_regulation CCL2 TNF 20069129 1213497 Positive_regulation CCL2 TNF 20305745 2214360 Positive_regulation CCL2 TNF 20406462 1853941 Positive_regulation CCL2 TNF 20700422 3174624 Positive_regulation CCL2 TNF 20700422 3174625 Positive_regulation CCL2 TNF 21029292 590577 Positive_regulation CCL2 TNF 21029292 590580 Positive_regulation CCL2 TNF 21403844 506725 Positive_regulation CCL2 TNF 21845215 1669467 Positive_regulation CCL2 TNF 21867503 627374 Positive_regulation CCL2 TNF 22110387 1058541 Positive_regulation CCL2 TNF 22115311 1697985 Positive_regulation CCL2 TNF 22115311 1697987 Positive_regulation CCL2 TNF 22125674 2115070 Positive_regulation CCL2 TNF 22125674 2115074 Positive_regulation CCL2 TNF 22125674 2115075 Positive_regulation CCL2 TNF 22125674 2115077 Positive_regulation CCL2 TNF 22125674 2115080 Positive_regulation CCL2 TNF 22132330 1155366 Positive_regulation CCL2 TNF 22291719 1156028 Positive_regulation CCL2 TNF 22293775 1886006 Positive_regulation CCL2 TNF 22293775 1886010 Positive_regulation CCL2 TNF 22393384 2608055 Positive_regulation CCL2 TNF 22393384 2608057 Positive_regulation CCL2 TNF 22414048 1626493 Positive_regulation CCL2 TNF 22414048 1626494 Positive_regulation CCL2 TNF 22507528 1661621 Positive_regulation CCL2 TNF 22566778 3152658 Positive_regulation CCL2 TNF 22629114 645380 Positive_regulation CCL2 TNF 22701457 901679 Positive_regulation CCL2 TNF 22723832 2654709 Positive_regulation CCL2 TNF 22723832 2654737 Positive_regulation CCL2 TNF 22723832 2654772 Positive_regulation CCL2 TNF 22754320 1095963 Positive_regulation CCL2 TNF 22768975 1664334 Positive_regulation CCL2 TNF 22816003 2371455 Positive_regulation CCL2 TNF 22824914 834872 Positive_regulation CCL2 TNF 22824914 834874 Positive_regulation CCL2 TNF 22912822 2679369 Positive_regulation CCL2 TNF 22912822 2679370 Positive_regulation CCL2 TNF 23028874 2693484 Positive_regulation CCL2 TNF 23056947 1145836 Positive_regulation CCL2 TNF 23077623 2705025 Positive_regulation CCL2 TNF 23285282 2733420 Positive_regulation CCL2 TNF 23364987 3233054 Positive_regulation CCL2 TNF 23383064 2747761 Positive_regulation CCL2 TNF 23383064 2747766 Positive_regulation CCL2 TNF 23420676 2163527 Positive_regulation CCL2 TNF 23420676 2163528 Positive_regulation CCL2 TNF 23420676 2163529 Positive_regulation CCL2 TNF 23420676 2163561 Positive_regulation CCL2 TNF 23420676 2163562 Positive_regulation CCL2 TNF 23455155 2110744 Positive_regulation CCL2 TNF 23468966 2760303 Positive_regulation CCL2 TNF 23577023 3076687 Positive_regulation CCL2 TNF 23577023 3076688 Positive_regulation CCL2 TNF 23607100 181448 Positive_regulation CCL2 TNF 23607100 181453 Positive_regulation CCL2 TNF 23762160 820138 Positive_regulation CCL2 TNF 23762160 820141 Positive_regulation CCL2 TNF 23776651 2805362 Positive_regulation CCL2 TNF 23840908 2818789 Positive_regulation CCL2 TNF 23840908 2818794 Positive_regulation CCL2 TNF 23840908 2818812 Positive_regulation CCL2 TNF 23841502 367166 Positive_regulation CCL2 TNF 23861608 2220536 Positive_regulation CCL2 TNF 23878415 1754319 Positive_regulation CCL2 TNF 23878502 1916095 Positive_regulation CCL2 TNF 23908975 649283 Positive_regulation CCL2 TNF 24064574 2118061 Positive_regulation CCL2 TNF 24064574 2118062 Positive_regulation CCL2 TNF 24088372 2233549 Positive_regulation CCL2 TNF 24098382 2856020 Positive_regulation CCL2 TNF 24130892 2867507 Positive_regulation CCL2 TNF 24130892 2867517 Positive_regulation CCL2 TNF 24130892 2867526 Positive_regulation CCL2 TNF 24141950 1991005 Positive_regulation CCL2 TNF 24223177 2876610 Positive_regulation CCL2 TNF 24347831 1755870 Positive_regulation CCL2 TNF 24405660 1667531 Positive_regulation CCL2 TNF 24416415 2908728 Positive_regulation CCL2 TNF 24416415 2908745 Positive_regulation CCL2 TNF 24416415 2908750 Positive_regulation CCL2 TNF 24426777 1916718 Positive_regulation CCL2 TNF 24426777 1916719 Positive_regulation CCL2 TNF 24426777 1916727 Positive_regulation CCL2 TNF 24426777 1916728 Positive_regulation CCL2 TNF 24426777 1916731 Positive_regulation CCL2 TNF 24426777 1916732 Positive_regulation CCL2 TNF 24489848 2916450 Positive_regulation CCL2 TNF 24603712 2931967 Positive_regulation CCL2 TNF 24608713 2932836 Positive_regulation CCL2 TNF 24659953 869061 Positive_regulation CCL2 TNF 24920309 1668200 Positive_regulation CCL2 TNF 24931417 34216 Positive_regulation CCL2 TNF 24945146 2980854 Positive_regulation CCL2 TNF 24971321 193310 Positive_regulation CCL2 TNF 25009502 965405 Positive_regulation CCL2 TNF 25009785 3094569 Positive_regulation CCL2 TNF 25017038 1087519 Positive_regulation CCL2 TNF 25053922 1627947 Positive_regulation CCL2 TNF 25110549 2229769 Positive_regulation CCL2 TNF 25117537 2996613 Positive_regulation CCL2 TNF 25165721 198426 Positive_regulation CCL2 TNF 25229347 3007949 Positive_regulation CCL2 TNF 25229347 3007959 Positive_regulation CCL2 TNF 25229347 3007960 Positive_regulation CCL2 TNF 25229347 3007963 Positive_regulation CCL2 TNF 25229347 3007964 Positive_regulation CCL2 TNF 25229347 3007966 Positive_regulation CCL2 TNF 25269075 3011854 Positive_regulation CCL2 TNF 25317018 1636210 Positive_regulation CCL2 TNF 25317018 1636211 Positive_regulation CCL2 TNF 9792337 1763849 Positive_regulation CCL2 TNF PMC2222796 448418 Positive_regulation CCL2 TNF PMC3301465 660972 Positive_regulation CCL2 TNF PMC4036662 2246691 Positive_regulation CCL2 TP63 22606349 2643315 Positive_regulation CCL20 EPHB2 24436142 1023849 Positive_regulation CCL20 F2R 21029417 354055 Positive_regulation CCL20 F2R 21029417 354066 Positive_regulation CCL20 FOXO1 25226535 1130155 Positive_regulation CCL20 MAP2K6 19340288 2411462 Positive_regulation CCL20 TNF 21050487 3213360 Positive_regulation CCL20 TNF 21881590 1630490 Positive_regulation CCL20 TNF 21881590 1630491 Positive_regulation CCL20 TNF 21881590 1630492 Positive_regulation CCL20 TNF 21881590 1630493 Positive_regulation CCL20 TNF 21881590 1630504 Positive_regulation CCL20 TNF 21931826 2554969 Positive_regulation CCL20 TNF 23238132 651882 Positive_regulation CCL20 TNF 23238132 651883 Positive_regulation CCL20 TNF 23283206 3225499 Positive_regulation CCL20 TNF 23283206 3225500 Positive_regulation CCL20 TNF 23283206 3225530 Positive_regulation CCL20 TNF 23283206 3225534 Positive_regulation CCL20 TNF 23283206 3225560 Positive_regulation CCL20 TNF 23300534 2733674 Positive_regulation CCL20 TNF 23469071 2761188 Positive_regulation CCL20 TNF 23800251 1627018 Positive_regulation CCL20 TNF 23800251 1627049 Positive_regulation CCL20 TNF 23800251 1627131 Positive_regulation CCL20 TNF 24534191 1575090 Positive_regulation CCL20 TNF 24562309 1959946 Positive_regulation CCL20 TNF 24722370 2951371 Positive_regulation CCL20 TNF 24722370 2951375 Positive_regulation CCL20 TNF 24722370 2951379 Positive_regulation CCL21 EPHB2 21698152 2530440 Positive_regulation CCL21 ITGAL 24945611 2981345 Positive_regulation CCL21 ITGAL 24945611 2981351 Positive_regulation CCL21 TLR7 20617179 3047943 Positive_regulation CCL21 TNF 20126461 2438908 Positive_regulation CCL21 TNF 9892622 1605087 Positive_regulation CCL21 TNF 9892622 1605094 Positive_regulation CCL22 CCL17 22916101 2679901 Positive_regulation CCL22 CCL17 24534492 810325 Positive_regulation CCL23 MMP28 22147696 1200795 Positive_regulation CCL23 MMP7 22147696 1200810 Positive_regulation CCL23 TNF 10974036 1516920 Positive_regulation CCL23 TNF 10974036 1516924 Positive_regulation CCL23 TNF 23283206 3225503 Positive_regulation CCL23 TNF 23283206 3225504 Positive_regulation CCL23 TNF 23283206 3225531 Positive_regulation CCL23 TNF 23283206 3225536 Positive_regulation CCL23 TNF 23283206 3225563 Positive_regulation CCL23 TNF 23331383 1675455 Positive_regulation CCL23 TNF 23331383 1675523 Positive_regulation CCL23 TNF 23331383 1675525 Positive_regulation CCL23 TNF 23331383 1675527 Positive_regulation CCL24 CCL17 23638129 2787758 Positive_regulation CCL25 FOXO1 21539750 3226270 Positive_regulation CCL25 TNF 17653288 2377254 Positive_regulation CCL26 CCL17 23951310 2834163 Positive_regulation CCL26 TNF 23878502 1916091 Positive_regulation CCL27 CCL17 22916101 2679902 Positive_regulation CCL27 TNF 25097473 3070937 Positive_regulation CCL28 AGR2 22174895 2582473 Positive_regulation CCL28 TNF 23300534 2733678 Positive_regulation CCL28 TNF 23300534 2733686 Positive_regulation CCL3 EPHB2 21403648 1720202 Positive_regulation CCL3 TLR7 19564352 1555338 Positive_regulation CCL3 TNF 20634957 2455652 Positive_regulation CCL3 TNF 21049294 665224 Positive_regulation CCL3 TNF 22241983 3055377 Positive_regulation CCL4 FOXO1 24864265 191761 Positive_regulation CCL4 TNF 19668438 649344 Positive_regulation CCL4 TNF 24864265 191760 Positive_regulation CCL5 EPHB2 23326556 2740681 Positive_regulation CCL5 FOXO1 24864265 191776 Positive_regulation CCL5 IL1B 23717664 2798673 Positive_regulation CCL5 MMP28 20604932 119453 Positive_regulation CCL5 MMP7 20604932 119469 Positive_regulation CCL5 SPHK1 24464131 1959652 Positive_regulation CCL5 TLR7 25211222 3006788 Positive_regulation CCL5 TLR7 25392121 1946654 Positive_regulation CCL5 TNF 12559043 457604 Positive_regulation CCL5 TNF 14514472 1738989 Positive_regulation CCL5 TNF 14514472 1738990 Positive_regulation CCL5 TNF 14514472 1738991 Positive_regulation CCL5 TNF 14514472 1738993 Positive_regulation CCL5 TNF 14514472 1738994 Positive_regulation CCL5 TNF 14514472 1738995 Positive_regulation CCL5 TNF 16277688 104758 Positive_regulation CCL5 TNF 19934004 711831 Positive_regulation CCL5 TNF 20604932 119269 Positive_regulation CCL5 TNF 21298010 2499325 Positive_regulation CCL5 TNF 21855683 83493 Positive_regulation CCL5 TNF 22738652 1621039 Positive_regulation CCL5 TNF 23717673 2798737 Positive_regulation CCL5 TNF 23717673 2798739 Positive_regulation CCL5 TNF 24479486 1667595 Positive_regulation CCL5 TNF 24479486 1667597 Positive_regulation CCL5 TNF 24523572 1757471 Positive_regulation CCL5 TNF 24603712 2931968 Positive_regulation CCL5 TNF PMC3332453 134780 Positive_regulation CCL7 MIP 7507512 1588871 Positive_regulation CCL7 SMN2 22669976 1203620 Positive_regulation CCL7 SMN2 22669976 1203652 Positive_regulation CCL7 TNFSF10 22194670 3152396 Positive_regulation CCNA2 EPHB2 20526329 1924900 Positive_regulation CCNA2 ID1 22139302 1879317 Positive_regulation CCNA2 ID1 22139302 1879318 Positive_regulation CCNA2 ID1 22139302 1879350 Positive_regulation CCNA2 ID1 22139302 1879351 Positive_regulation CCNA2 ID1 22139302 1879394 Positive_regulation CCNA2 ID1 22139302 1879440 Positive_regulation CCNA2 ID1 22139302 1879458 Positive_regulation CCNA2 IFI27 18922157 1503343 Positive_regulation CCNA2 IFI27 23055977 959141 Positive_regulation CCNB1 EPHB2 23573134 818422 Positive_regulation CCNB1 EPHB2 23573134 818423 Positive_regulation CCNB1 EPHB2 23573134 818428 Positive_regulation CCNB1 EPHB2 24959718 2983159 Positive_regulation CCNB1 MAP2K6 11238451 1267572 Positive_regulation CCNB2 MAP2K6 11238451 1267579 Positive_regulation CCNC EDN2 9792333 1763663 Positive_regulation CCNC EPHB2 12769834 369122 Positive_regulation CCNC EPHB2 22216095 2584363 Positive_regulation CCNC EPHB2 22319481 860845 Positive_regulation CCNC EPHB2 22817771 471900 Positive_regulation CCNC EPHB2 24045785 3137170 Positive_regulation CCNC RCAN1 19124655 1553405 Positive_regulation CCNC TLR7 18584038 3072865 Positive_regulation CCNC TLR7 18584038 3073617 Positive_regulation CCNC TLR7 18815618 631483 Positive_regulation CCNC TLR7 20871832 1748016 Positive_regulation CCNC TLR7 22785227 1919013 Positive_regulation CCNC TNF 19712471 1625663 Positive_regulation CCNC TNF 22566867 899027 Positive_regulation CCNC TNF 23824685 2809183 Positive_regulation CCNC TNF 24300561 2247602 Positive_regulation CCNC TNF 24971461 2984430 Positive_regulation CCNC TNF 25275456 2373023 Positive_regulation CCNC TNF 3435705 443403 Positive_regulation CCNC TNF 7540649 1590322 Positive_regulation CCND1 ABCC6 21318168 1219126 Positive_regulation CCND1 ADAM10 21423681 798543 Positive_regulation CCND1 ADCY5 25077541 577794 Positive_regulation CCND1 ADCY5 25077541 577795 Positive_regulation CCND1 ADIPOQ 25051362 2196779 Positive_regulation CCND1 AGR2 20525379 465594 Positive_regulation CCND1 AHSA1 17407548 1846296 Positive_regulation CCND1 AHSA1 22404972 528331 Positive_regulation CCND1 AHSA1 22404972 528334 Positive_regulation CCND1 AHSA1 24189219 1120985 Positive_regulation CCND1 AKT1 11737885 457251 Positive_regulation CCND1 AKT1 17200689 1054614 Positive_regulation CCND1 AKT1 19183448 252343 Positive_regulation CCND1 AKT1 19814803 1852088 Positive_regulation CCND1 AKT1 19935697 2128263 Positive_regulation CCND1 AKT1 20414334 1066289 Positive_regulation CCND1 AKT1 21132000 12231 Positive_regulation CCND1 AKT1 21179458 2488070 Positive_regulation CCND1 AKT1 21297902 496661 Positive_regulation CCND1 AKT1 22269172 313478 Positive_regulation CCND1 AKT1 22799881 265284 Positive_regulation CCND1 AKT1 22799881 265307 Positive_regulation CCND1 AKT1 23300886 2737028 Positive_regulation CCND1 AKT1 23383245 2749748 Positive_regulation CCND1 AKT1 23511556 440339 Positive_regulation CCND1 AKT1 23511556 440365 Positive_regulation CCND1 AKT1 23552696 2156331 Positive_regulation CCND1 AKT1 23737653 1753227 Positive_regulation CCND1 AKT1 23895220 269522 Positive_regulation CCND1 AKT1 24223057 824098 Positive_regulation CCND1 AKT1 24276377 2244707 Positive_regulation CCND1 AKT1 24348821 2167418 Positive_regulation CCND1 AKT1 24577313 1124427 Positive_regulation CCND1 AKT1 24577313 1124472 Positive_regulation CCND1 AKT1 24690900 2947230 Positive_regulation CCND1 AKT1 24859236 2974778 Positive_regulation CCND1 AKT1 24904527 880725 Positive_regulation CCND1 AKT1 24970807 2193928 Positive_regulation CCND1 AKT1 25000529 2986897 Positive_regulation CCND1 AKT1 25036031 1128415 Positive_regulation CCND1 AKT1 25047753 240757 Positive_regulation CCND1 AKT1 25386348 3092750 Positive_regulation CCND1 AKT1 25486524 2160764 Positive_regulation CCND1 AKT1 25486524 2160775 Positive_regulation CCND1 AKT1 25486524 2160776 Positive_regulation CCND1 AKT2 11737885 457252 Positive_regulation CCND1 AKT2 17200689 1054615 Positive_regulation CCND1 AKT2 19183448 252344 Positive_regulation CCND1 AKT2 19814803 1852089 Positive_regulation CCND1 AKT2 19935697 2128264 Positive_regulation CCND1 AKT2 20414334 1066290 Positive_regulation CCND1 AKT2 21132000 12232 Positive_regulation CCND1 AKT2 21179458 2488071 Positive_regulation CCND1 AKT2 21297902 496662 Positive_regulation CCND1 AKT2 22269172 313479 Positive_regulation CCND1 AKT2 22799881 265285 Positive_regulation CCND1 AKT2 22799881 265308 Positive_regulation CCND1 AKT2 23300886 2737029 Positive_regulation CCND1 AKT2 23383245 2749749 Positive_regulation CCND1 AKT2 23511556 440340 Positive_regulation CCND1 AKT2 23511556 440366 Positive_regulation CCND1 AKT2 23552696 2156332 Positive_regulation CCND1 AKT2 23737653 1753228 Positive_regulation CCND1 AKT2 23895220 269523 Positive_regulation CCND1 AKT2 24223057 824099 Positive_regulation CCND1 AKT2 24276377 2244708 Positive_regulation CCND1 AKT2 24348821 2167419 Positive_regulation CCND1 AKT2 24577313 1124428 Positive_regulation CCND1 AKT2 24577313 1124473 Positive_regulation CCND1 AKT2 24690900 2947231 Positive_regulation CCND1 AKT2 24859236 2974779 Positive_regulation CCND1 AKT2 24970807 2193929 Positive_regulation CCND1 AKT2 25000529 2986898 Positive_regulation CCND1 AKT2 25036031 1128416 Positive_regulation CCND1 AKT2 25047753 240758 Positive_regulation CCND1 AKT2 25386348 3092751 Positive_regulation CCND1 AKT2 25486524 2160765 Positive_regulation CCND1 AKT2 25486524 2160777 Positive_regulation CCND1 AKT2 25486524 2160778 Positive_regulation CCND1 AKT3 11737885 457253 Positive_regulation CCND1 AKT3 17200689 1054616 Positive_regulation CCND1 AKT3 19183448 252345 Positive_regulation CCND1 AKT3 19814803 1852090 Positive_regulation CCND1 AKT3 19935697 2128265 Positive_regulation CCND1 AKT3 20414334 1066291 Positive_regulation CCND1 AKT3 21132000 12233 Positive_regulation CCND1 AKT3 21179458 2488072 Positive_regulation CCND1 AKT3 21297902 496663 Positive_regulation CCND1 AKT3 22269172 313480 Positive_regulation CCND1 AKT3 22799881 265286 Positive_regulation CCND1 AKT3 22799881 265309 Positive_regulation CCND1 AKT3 23300886 2737030 Positive_regulation CCND1 AKT3 23383245 2749750 Positive_regulation CCND1 AKT3 23511556 440341 Positive_regulation CCND1 AKT3 23511556 440367 Positive_regulation CCND1 AKT3 23552696 2156333 Positive_regulation CCND1 AKT3 23737653 1753229 Positive_regulation CCND1 AKT3 23895220 269524 Positive_regulation CCND1 AKT3 24223057 824100 Positive_regulation CCND1 AKT3 24276377 2244709 Positive_regulation CCND1 AKT3 24348821 2167420 Positive_regulation CCND1 AKT3 24577313 1124429 Positive_regulation CCND1 AKT3 24577313 1124474 Positive_regulation CCND1 AKT3 24690900 2947232 Positive_regulation CCND1 AKT3 24859236 2974780 Positive_regulation CCND1 AKT3 24970807 2193930 Positive_regulation CCND1 AKT3 25000529 2986899 Positive_regulation CCND1 AKT3 25036031 1128417 Positive_regulation CCND1 AKT3 25047753 240759 Positive_regulation CCND1 AKT3 25386348 3092752 Positive_regulation CCND1 AKT3 25486524 2160766 Positive_regulation CCND1 AKT3 25486524 2160779 Positive_regulation CCND1 AKT3 25486524 2160780 Positive_regulation CCND1 AMACR 25473890 2207476 Positive_regulation CCND1 ANGPT2 20037604 8636 Positive_regulation CCND1 ANGPT2 20037604 8637 Positive_regulation CCND1 ANGPT2 20037604 8688 Positive_regulation CCND1 ANGPT2 20037604 8689 Positive_regulation CCND1 ANGPT2 20037604 8701 Positive_regulation CCND1 ANO1 22912841 2679578 Positive_regulation CCND1 ANXA1 23549262 1104486 Positive_regulation CCND1 ANXA6 24970389 411240 Positive_regulation CCND1 APC 17407548 1846310 Positive_regulation CCND1 APP 11266469 1269219 Positive_regulation CCND1 ARF1 22860097 2671582 Positive_regulation CCND1 ARF3 22860097 2671583 Positive_regulation CCND1 ARF4 22860097 2671584 Positive_regulation CCND1 ARF5 22860097 2671585 Positive_regulation CCND1 ARF6 22860097 2671586 Positive_regulation CCND1 ARHGEF2 19730435 785916 Positive_regulation CCND1 ARHGEF2 19730435 785921 Positive_regulation CCND1 ARHGEF2 19730435 785933 Positive_regulation CCND1 ARHGEF2 19730435 785934 Positive_regulation CCND1 ARHGEF2 19730435 785935 Positive_regulation CCND1 ATF1 24708550 272608 Positive_regulation CCND1 ATF2 16984628 370054 Positive_regulation CCND1 ATF2 21429205 626978 Positive_regulation CCND1 ATF2 21429205 626981 Positive_regulation CCND1 ATF2 22404972 528336 Positive_regulation CCND1 ATF2 22919439 2224663 Positive_regulation CCND1 ATF2 22919439 2224666 Positive_regulation CCND1 ATF2 24708550 272609 Positive_regulation CCND1 ATF3 23591848 1105883 Positive_regulation CCND1 ATF3 23591848 1105884 Positive_regulation CCND1 ATF3 23591848 1105890 Positive_regulation CCND1 ATF3 23591848 1105891 Positive_regulation CCND1 ATF3 24222778 823978 Positive_regulation CCND1 ATF3 24708550 272610 Positive_regulation CCND1 ATF4 19851510 2429562 Positive_regulation CCND1 ATF4 24708550 272611 Positive_regulation CCND1 ATF5 24708550 272612 Positive_regulation CCND1 ATF6 24708550 272613 Positive_regulation CCND1 ATF7 24708550 272614 Positive_regulation CCND1 ATM 23776433 2804250 Positive_regulation CCND1 ATM 23776433 2804256 Positive_regulation CCND1 ATM 23776433 2804257 Positive_regulation CCND1 ATM 23776433 2804266 Positive_regulation CCND1 ATM 23776433 2804282 Positive_regulation CCND1 ATM 23776433 2804289 Positive_regulation CCND1 ATR 19903334 3091209 Positive_regulation CCND1 ATR 19903334 3091210 Positive_regulation CCND1 AXIN1 21711594 519058 Positive_regulation CCND1 AXIN1 24931005 2192190 Positive_regulation CCND1 AXIN2 21711594 519059 Positive_regulation CCND1 AXIN2 24931005 2192191 Positive_regulation CCND1 BCL10 18764945 583284 Positive_regulation CCND1 BCL2 19531256 464500 Positive_regulation CCND1 BCL2 24022053 1905799 Positive_regulation CCND1 BCL6 24282530 2886158 Positive_regulation CCND1 BCL6 24917186 273854 Positive_regulation CCND1 BCL6 24917186 273860 Positive_regulation CCND1 BCL6 24917186 273861 Positive_regulation CCND1 BCL6 24917186 273865 Positive_regulation CCND1 BCL6 24917186 273869 Positive_regulation CCND1 BCLAF1 22833098 557268 Positive_regulation CCND1 BEX2 20482821 1855187 Positive_regulation CCND1 BEX2 20482821 1855251 Positive_regulation CCND1 BEX2 20482821 1855267 Positive_regulation CCND1 BEX2 20482821 1855275 Positive_regulation CCND1 BMP1 16823072 1075276 Positive_regulation CCND1 BMP2 21604139 1639758 Positive_regulation CCND1 BRCA1 22431556 2179924 Positive_regulation CCND1 BRCA1 22431556 2179933 Positive_regulation CCND1 BRCA1 PMC3300725 477059 Positive_regulation CCND1 BRD2 24048450 1818619 Positive_regulation CCND1 BRD8 22276175 2590340 Positive_regulation CCND1 BTRC 17205132 2374354 Positive_regulation CCND1 C9orf3 23670595 1106859 Positive_regulation CCND1 CALM3 17092340 580163 Positive_regulation CCND1 CALM3 17092340 580179 Positive_regulation CCND1 CALM3 22020328 2144303 Positive_regulation CCND1 CAPN1 17407548 1846298 Positive_regulation CCND1 CAPN10 17407548 1846299 Positive_regulation CCND1 CAPN11 17407548 1846300 Positive_regulation CCND1 CAPN12 17407548 1846297 Positive_regulation CCND1 CAPN13 17407548 1846308 Positive_regulation CCND1 CAPN14 17407548 1846309 Positive_regulation CCND1 CAPN15 17407548 1846295 Positive_regulation CCND1 CAPN2 17407548 1846301 Positive_regulation CCND1 CAPN3 17407548 1846302 Positive_regulation CCND1 CAPN5 17407548 1846303 Positive_regulation CCND1 CAPN6 17407548 1846304 Positive_regulation CCND1 CAPN7 17407548 1846305 Positive_regulation CCND1 CAPN8 17407548 1846306 Positive_regulation CCND1 CAPN9 17407548 1846307 Positive_regulation CCND1 CARM1 19725955 302660 Positive_regulation CCND1 CARM1 19725955 302661 Positive_regulation CCND1 CARM1 19725955 302662 Positive_regulation CCND1 CARM1 19725955 302672 Positive_regulation CCND1 CARM1 19725955 302675 Positive_regulation CCND1 CARM1 19725955 302683 Positive_regulation CCND1 CASP3 23586056 181324 Positive_regulation CCND1 CASP3 24083380 1649979 Positive_regulation CCND1 CASP3 25051362 2196778 Positive_regulation CCND1 CAT 10953010 1262079 Positive_regulation CCND1 CAV1 23521716 1480102 Positive_regulation CCND1 CAV2 22229094 154619 Positive_regulation CCND1 CCAR2 21596782 2063192 Positive_regulation CCND1 CCDC19 24976536 1483698 Positive_regulation CCND1 CCL19 24915301 2979165 Positive_regulation CCND1 CCL19 24915301 2979166 Positive_regulation CCND1 CCL19 24915301 2979167 Positive_regulation CCND1 CCL19 24915301 2979168 Positive_regulation CCND1 CCL19 24915301 2979178 Positive_regulation CCND1 CCL19 24915301 2979179 Positive_regulation CCND1 CCL19 24915301 2979180 Positive_regulation CCND1 CCL21 21698152 2530520 Positive_regulation CCND1 CCL5 21930774 1391779 Positive_regulation CCND1 CCND1 17296798 1337094 Positive_regulation CCND1 CCND1 PMC4271004 1675268 Positive_regulation CCND1 CCND2 17134502 359548 Positive_regulation CCND1 CCND3 20113529 1853269 Positive_regulation CCND1 CCNE1 24356446 1820095 Positive_regulation CCND1 CCNE1 25047753 240755 Positive_regulation CCND1 CCNG1 PMC4185361 787282 Positive_regulation CCND1 CD2 20459685 1854908 Positive_regulation CCND1 CD4 19707583 2424542 Positive_regulation CCND1 CD44 17296798 1337095 Positive_regulation CCND1 CD44 17296798 1337117 Positive_regulation CCND1 CD44 19506034 1366824 Positive_regulation CCND1 CD44 19506034 1366825 Positive_regulation CCND1 CDC73 19906718 2048295 Positive_regulation CCND1 CDC73 24842573 2971782 Positive_regulation CCND1 CDK2 10376986 414410 Positive_regulation CCND1 CDK2 23075291 1867200 Positive_regulation CCND1 CDK2 23320178 1065263 Positive_regulation CCND1 CDK2 23320178 1065264 Positive_regulation CCND1 CDK2 8609171 1451006 Positive_regulation CCND1 CDK2 8609171 1451038 Positive_regulation CCND1 CDK2 9168007 797212 Positive_regulation CCND1 CDK4 16863592 580005 Positive_regulation CCND1 CDK4 17296798 1337096 Positive_regulation CCND1 CDK4 17407548 1846314 Positive_regulation CCND1 CDK4 17535444 300044 Positive_regulation CCND1 CDK4 25177151 454757 Positive_regulation CCND1 CDK5 21494687 2513525 Positive_regulation CCND1 CDK5 25104955 971467 Positive_regulation CCND1 CDK6 19863813 584384 Positive_regulation CCND1 CDK6 25120649 2169250 Positive_regulation CCND1 CDKN1A 10952788 417754 Positive_regulation CCND1 CDKN1A 11134071 1266105 Positive_regulation CCND1 CDKN1A 11259090 418391 Positive_regulation CCND1 CDKN1A 16879721 1163605 Positive_regulation CCND1 CDKN1A 17092340 580180 Positive_regulation CCND1 CDKN1A 17092340 580213 Positive_regulation CCND1 CDKN1A 17092340 580214 Positive_regulation CCND1 CDKN1A 19703290 1625538 Positive_regulation CCND1 CDKN1A 19828076 236134 Positive_regulation CCND1 CDKN1A 19828076 236138 Positive_regulation CCND1 CDKN1A 22481926 1673476 Positive_regulation CCND1 CDKN1A 22833098 557269 Positive_regulation CCND1 CDKN1A 22860097 2671566 Positive_regulation CCND1 CDKN1A 22860097 2671594 Positive_regulation CCND1 CDKN1A 23181557 292647 Positive_regulation CCND1 CDKN1A 23340319 2117183 Positive_regulation CCND1 CDKN1A 23344177 1905717 Positive_regulation CCND1 CDKN1A 23702334 363768 Positive_regulation CCND1 CDKN1A 23755177 2801662 Positive_regulation CCND1 CDKN1A 23786849 473330 Positive_regulation CCND1 CDKN1A 23843843 1238237 Positive_regulation CCND1 CDKN1A 24505435 2920889 Positive_regulation CCND1 CDKN1A 24505435 2920896 Positive_regulation CCND1 CDKN1A 24747418 2955862 Positive_regulation CCND1 CDKN1A 24926661 2979778 Positive_regulation CCND1 CDKN1A 25164084 1484582 Positive_regulation CCND1 CDKN1A 25477755 657795 Positive_regulation CCND1 CDKN1A 9864370 1473426 Positive_regulation CCND1 CDKN1A PMC3300260 476987 Positive_regulation CCND1 CDKN1B 19828076 236135 Positive_regulation CCND1 CDKN1B 19828076 236139 Positive_regulation CCND1 CDKN1B 23807222 563489 Positive_regulation CCND1 CDKN1B 24252239 178790 Positive_regulation CCND1 CDKN1B 24252239 178792 Positive_regulation CCND1 CDKN2A 22860097 2671567 Positive_regulation CCND1 CDKN2A 22860097 2671571 Positive_regulation CCND1 CDKN2A 22860097 2671573 Positive_regulation CCND1 CDKN2A 22860097 2671595 Positive_regulation CCND1 CDKN2A 22860097 2671596 Positive_regulation CCND1 CDKN2A 22988546 941270 Positive_regulation CCND1 CDKN2A 24741325 487757 Positive_regulation CCND1 CDKN2B 18021445 250611 Positive_regulation CCND1 CDKN2C 22548705 1865883 Positive_regulation CCND1 CEND1 24312406 2889206 Positive_regulation CCND1 CEND1 24312406 2889217 Positive_regulation CCND1 CEND1 24312406 2889226 Positive_regulation CCND1 CEND1 24312406 2889231 Positive_regulation CCND1 CIAPIN1 25000876 3082684 Positive_regulation CCND1 CISH 17200689 1054629 Positive_regulation CCND1 CISH 21858227 2546999 Positive_regulation CCND1 CNR2 20803555 1237764 Positive_regulation CCND1 CNTN2 20101207 2128677 Positive_regulation CCND1 CNTN2 20101207 2128678 Positive_regulation CCND1 CNTN2 20101207 2128685 Positive_regulation CCND1 CNTN2 20101207 2128692 Positive_regulation CCND1 CNTN2 20101207 2128740 Positive_regulation CCND1 CNTN2 20101207 2128743 Positive_regulation CCND1 CNTN2 22726420 336943 Positive_regulation CCND1 CPE 24006921 269676 Positive_regulation CCND1 CPE 24006921 269677 Positive_regulation CCND1 CPE 24006921 269678 Positive_regulation CCND1 CRABP1 15714209 425374 Positive_regulation CCND1 CREB1 11696562 1276066 Positive_regulation CCND1 CREB1 16984628 370052 Positive_regulation CCND1 CREB1 20101207 2128686 Positive_regulation CCND1 CREB1 24223660 843814 Positive_regulation CCND1 CREB1 24979279 2160540 Positive_regulation CCND1 CREB3 11696562 1276067 Positive_regulation CCND1 CREB3 16984628 370053 Positive_regulation CCND1 CREB3 20101207 2128687 Positive_regulation CCND1 CREB3 24223660 843815 Positive_regulation CCND1 CREB3 24979279 2160541 Positive_regulation CCND1 CREB5 11696562 1276065 Positive_regulation CCND1 CREB5 16984628 370051 Positive_regulation CCND1 CREB5 20101207 2128684 Positive_regulation CCND1 CREB5 24223660 843813 Positive_regulation CCND1 CREB5 24979279 2160539 Positive_regulation CCND1 CRK 22404972 528343 Positive_regulation CCND1 CRK 22404972 528363 Positive_regulation CCND1 CRTC2 20101207 2128679 Positive_regulation CCND1 CRYGEP 24915301 2979169 Positive_regulation CCND1 CSE 20429916 3110324 Positive_regulation CCND1 CSE 20429916 3110347 Positive_regulation CCND1 CSE 20429916 3110348 Positive_regulation CCND1 CSNK1A1 24073882 1490640 Positive_regulation CCND1 CTDP1 22792345 2663315 Positive_regulation CCND1 CTGF 22684333 541564 Positive_regulation CCND1 CTGF 22684333 541565 Positive_regulation CCND1 CTNNB1 24025394 3102119 Positive_regulation CCND1 CTNNB1 24194897 2872619 Positive_regulation CCND1 CTNNB1 24256736 1700936 Positive_regulation CCND1 CTNNB1 24339928 2894293 Positive_regulation CCND1 CTNND1 22276175 2590341 Positive_regulation CCND1 CTNND1 22276175 2590342 Positive_regulation CCND1 CTNND1 24979278 2160486 Positive_regulation CCND1 CTNND1 24979278 2160519 Positive_regulation CCND1 CUL1 17205132 2374355 Positive_regulation CCND1 CUL1 17205132 2374360 Positive_regulation CCND1 CUL7 17205132 2374359 Positive_regulation CCND1 CYLD 19124656 1553505 Positive_regulation CCND1 CYLD 19124656 1553506 Positive_regulation CCND1 CYLD 19124656 1553507 Positive_regulation CCND1 CYLD 19124656 1553508 Positive_regulation CCND1 CYLD 19124656 1553509 Positive_regulation CCND1 CYLD 19124656 1553539 Positive_regulation CCND1 CYLD 22832488 1631060 Positive_regulation CCND1 DACT1 22470507 2614481 Positive_regulation CCND1 DDRGK1 23675531 2793558 Positive_regulation CCND1 DDRGK1 23675531 2793560 Positive_regulation CCND1 DDRGK1 23675531 2793563 Positive_regulation CCND1 DHX9 22520625 521182 Positive_regulation CCND1 DNMT3A 22481891 989692 Positive_regulation CCND1 DNMT3B 22481891 989693 Positive_regulation CCND1 DST 23279634 1479175 Positive_regulation CCND1 DUSP16 25077541 577793 Positive_regulation CCND1 DUSP16 25077541 577847 Positive_regulation CCND1 DYRK1B 17407548 1846376 Positive_regulation CCND1 DYRK1B 17407548 1846390 Positive_regulation CCND1 E2F1 17535444 300048 Positive_regulation CCND1 E2F1 22768064 2659600 Positive_regulation CCND1 E2F1 23650533 2788890 Positive_regulation CCND1 E2F1 24171117 1151423 Positive_regulation CCND1 E2F1 PMC4185361 787286 Positive_regulation CCND1 E2F2 17535444 300049 Positive_regulation CCND1 E2F2 23650533 2788891 Positive_regulation CCND1 E2F2 PMC4185361 787287 Positive_regulation CCND1 E2F3 17535444 300050 Positive_regulation CCND1 E2F3 23650533 2788892 Positive_regulation CCND1 E2F3 PMC4185361 787288 Positive_regulation CCND1 E2F4 17535444 300051 Positive_regulation CCND1 E2F4 23650533 2788893 Positive_regulation CCND1 E2F4 PMC4185361 787289 Positive_regulation CCND1 E2F5 17535444 300052 Positive_regulation CCND1 E2F5 23650533 2788894 Positive_regulation CCND1 E2F5 PMC4185361 787290 Positive_regulation CCND1 E2F6 17535444 300053 Positive_regulation CCND1 E2F6 23650533 2788895 Positive_regulation CCND1 E2F6 PMC4185361 787291 Positive_regulation CCND1 E2F7 17535444 300046 Positive_regulation CCND1 E2F7 23650533 2788888 Positive_regulation CCND1 E2F7 PMC4185361 787284 Positive_regulation CCND1 E2F8 17535444 300047 Positive_regulation CCND1 E2F8 23650533 2788889 Positive_regulation CCND1 E2F8 PMC4185361 787285 Positive_regulation CCND1 EDA 24244705 2881301 Positive_regulation CCND1 EEF2K 22911754 2676261 Positive_regulation CCND1 EGF 16984645 279312 Positive_regulation CCND1 EGF 17997837 461876 Positive_regulation CCND1 EGF 20302655 1853813 Positive_regulation CCND1 EGF 22927910 2680877 Positive_regulation CCND1 EGF 22927910 2680878 Positive_regulation CCND1 EGF 22927910 2680879 Positive_regulation CCND1 EGF 22927910 2680880 Positive_regulation CCND1 EGF 22927910 2680946 Positive_regulation CCND1 EGF 22927910 2680947 Positive_regulation CCND1 EGF 22927910 2680958 Positive_regulation CCND1 EGF 22927910 2680959 Positive_regulation CCND1 EGF 22927910 2680960 Positive_regulation CCND1 EGF 22927910 2680964 Positive_regulation CCND1 EGF 22927910 2680984 Positive_regulation CCND1 EGF 22927910 2680985 Positive_regulation CCND1 EGF 22927910 2680986 Positive_regulation CCND1 EGF 22927910 2681024 Positive_regulation CCND1 EGF 22927910 2681025 Positive_regulation CCND1 EGF 22927910 2681040 Positive_regulation CCND1 EGF 23119170 1079510 Positive_regulation CCND1 EGF 23259795 1699227 Positive_regulation CCND1 EGF 23919615 290079 Positive_regulation CCND1 EGF 24311896 1755567 Positive_regulation CCND1 EGF 24311896 1755583 Positive_regulation CCND1 EGF 24340049 2894770 Positive_regulation CCND1 EGF 24972138 1128063 Positive_regulation CCND1 EGF 9508775 1466684 Positive_regulation CCND1 EGF PMC3870845 626677 Positive_regulation CCND1 EGFR 16434982 426963 Positive_regulation CCND1 EGFR 19529774 2419449 Positive_regulation CCND1 EGFR 19878607 1852291 Positive_regulation CCND1 EGFR 19935697 2128207 Positive_regulation CCND1 EGFR 19935697 2128208 Positive_regulation CCND1 EGFR 19935697 2128209 Positive_regulation CCND1 EGFR 19935697 2128210 Positive_regulation CCND1 EGFR 19935697 2128229 Positive_regulation CCND1 EGFR 19935697 2128232 Positive_regulation CCND1 EGFR 19935697 2128259 Positive_regulation CCND1 EGFR 19935697 2128293 Positive_regulation CCND1 EGFR 19935697 2128294 Positive_regulation CCND1 EGFR 19935697 2128326 Positive_regulation CCND1 EGFR 20092659 1504033 Positive_regulation CCND1 EGFR 20092659 1504035 Positive_regulation CCND1 EGFR 20302655 1853751 Positive_regulation CCND1 EGFR 21165163 2174645 Positive_regulation CCND1 EGFR 22056988 1987987 Positive_regulation CCND1 EGFR 22520625 521183 Positive_regulation CCND1 EGFR 22520625 521186 Positive_regulation CCND1 EGFR 22733137 2147697 Positive_regulation CCND1 EGFR 22927910 2680987 Positive_regulation CCND1 EGFR 23457600 2758965 Positive_regulation CCND1 EGFR 24311896 1755568 Positive_regulation CCND1 EGFR 24499623 1507687 Positive_regulation CCND1 EGFR 24499623 1507688 Positive_regulation CCND1 EGFR 24499623 1507727 Positive_regulation CCND1 EGFR 24499623 1507728 Positive_regulation CCND1 EGFR 24499623 1507729 Positive_regulation CCND1 EGFR 24499623 1507730 Positive_regulation CCND1 EGFR 24499623 1507752 Positive_regulation CCND1 EGFR 25045438 1615849 Positive_regulation CCND1 EGR1 22140445 2574750 Positive_regulation CCND1 EGR1 22140445 2574751 Positive_regulation CCND1 EHMT2 19906718 2048311 Positive_regulation CCND1 EIF4E 12633504 479944 Positive_regulation CCND1 EIF4E 18498250 146248 Positive_regulation CCND1 ELAVL1 21902831 3160611 Positive_regulation CCND1 ELAVL1 23242178 477781 Positive_regulation CCND1 ELL 20657652 2456290 Positive_regulation CCND1 EPCAM 24940735 2980718 Positive_regulation CCND1 EPHB2 10491389 1249389 Positive_regulation CCND1 EPHB2 16584539 459769 Positive_regulation CCND1 EPHB2 17205132 2374320 Positive_regulation CCND1 EPHB2 17205132 2374377 Positive_regulation CCND1 EPHB2 17319972 1645442 Positive_regulation CCND1 EPHB2 18404517 3089660 Positive_regulation CCND1 EPHB2 18404517 3089680 Positive_regulation CCND1 EPHB2 19165201 431730 Positive_regulation CCND1 EPHB2 19703290 1625530 Positive_regulation CCND1 EPHB2 19707375 175678 Positive_regulation CCND1 EPHB2 20300579 3075067 Positive_regulation CCND1 EPHB2 20422052 2448095 Positive_regulation CCND1 EPHB2 20531308 2132611 Positive_regulation CCND1 EPHB2 20567632 648133 Positive_regulation CCND1 EPHB2 21283538 2495568 Positive_regulation CCND1 EPHB2 21541658 616617 Positive_regulation CCND1 EPHB2 22235328 2585827 Positive_regulation CCND1 EPHB2 22799764 265232 Positive_regulation CCND1 EPHB2 22833568 1806084 Positive_regulation CCND1 EPHB2 23029062 2694446 Positive_regulation CCND1 EPHB2 23335926 905767 Positive_regulation CCND1 EPHB2 23542180 218396 Positive_regulation CCND1 EPHB2 23895220 269521 Positive_regulation CCND1 EPHB2 23965971 1110021 Positive_regulation CCND1 EPHB2 24276851 606686 Positive_regulation CCND1 EPHB2 24577313 1124426 Positive_regulation CCND1 EPHB2 24577313 1124471 Positive_regulation CCND1 EPHB2 24624361 947533 Positive_regulation CCND1 EPHB2 24970807 2193927 Positive_regulation CCND1 EPHB2 25015194 2195696 Positive_regulation CCND1 EPHB2 PMC2169457 1474879 Positive_regulation CCND1 EPO 24004818 1618331 Positive_regulation CCND1 EPX 24004818 1618326 Positive_regulation CCND1 ERBB2 19648968 2126216 Positive_regulation CCND1 ERBB2 21272329 586177 Positive_regulation CCND1 ERBB2 24765191 2168352 Positive_regulation CCND1 ERBB3 23951180 2833647 Positive_regulation CCND1 ERBB3 23951180 2833649 Positive_regulation CCND1 ERBB3 23951180 2833652 Positive_regulation CCND1 ERBB3 23951180 2833663 Positive_regulation CCND1 ESR1 10390005 414579 Positive_regulation CCND1 ESR1 10682656 416198 Positive_regulation CCND1 ESR1 10901378 417270 Positive_regulation CCND1 ESR1 16863592 580009 Positive_regulation CCND1 ESR1 23351343 695276 Positive_regulation CCND1 ESR1 23637611 2345580 Positive_regulation CCND1 ETS1 23383271 2749841 Positive_regulation CCND1 ETS1 23874775 2822500 Positive_regulation CCND1 ETS2 11259090 418387 Positive_regulation CCND1 EZH2 24362326 18860 Positive_regulation CCND1 EZH2 25038756 496451 Positive_regulation CCND1 F2R 17319972 1645276 Positive_regulation CCND1 F2RL1 25247240 1906006 Positive_regulation CCND1 FABP4 24312381 2889056 Positive_regulation CCND1 FABP4 24312381 2889059 Positive_regulation CCND1 FBXL2 22020328 2144290 Positive_regulation CCND1 FBXO31 19412162 1983375 Positive_regulation CCND1 FBXO31 19412162 1983379 Positive_regulation CCND1 FBXO31 19412162 1983383 Positive_regulation CCND1 FBXO31 19412162 1983385 Positive_regulation CCND1 FBXO4 17407548 1846289 Positive_regulation CCND1 FBXO4 19767775 2127061 Positive_regulation CCND1 FBXW8 17205132 2374316 Positive_regulation CCND1 FBXW8 17205132 2374317 Positive_regulation CCND1 FBXW8 17205132 2374375 Positive_regulation CCND1 FBXW8 17205132 2374405 Positive_regulation CCND1 FGF1 11257130 1268025 Positive_regulation CCND1 FGF1 11257130 1268474 Positive_regulation CCND1 FGF10 11257130 1268026 Positive_regulation CCND1 FGF10 11257130 1268475 Positive_regulation CCND1 FGF11 11257130 1268027 Positive_regulation CCND1 FGF11 11257130 1268476 Positive_regulation CCND1 FGF12 11257130 1268028 Positive_regulation CCND1 FGF12 11257130 1268477 Positive_regulation CCND1 FGF13 11257130 1268029 Positive_regulation CCND1 FGF13 11257130 1268478 Positive_regulation CCND1 FGF14 11257130 1268030 Positive_regulation CCND1 FGF14 11257130 1268479 Positive_regulation CCND1 FGF16 11257130 1268031 Positive_regulation CCND1 FGF16 11257130 1268480 Positive_regulation CCND1 FGF17 11257130 1268032 Positive_regulation CCND1 FGF17 11257130 1268481 Positive_regulation CCND1 FGF18 11257130 1268033 Positive_regulation CCND1 FGF18 11257130 1268482 Positive_regulation CCND1 FGF19 11257130 1268034 Positive_regulation CCND1 FGF19 11257130 1268483 Positive_regulation CCND1 FGF19 23285165 2732797 Positive_regulation CCND1 FGF19 23285165 2732799 Positive_regulation CCND1 FGF19 23285165 2732800 Positive_regulation CCND1 FGF19 23285165 2732801 Positive_regulation CCND1 FGF2 11257130 1268035 Positive_regulation CCND1 FGF2 11257130 1268484 Positive_regulation CCND1 FGF2 18404517 3089661 Positive_regulation CCND1 FGF2 18404517 3089662 Positive_regulation CCND1 FGF2 18404517 3089663 Positive_regulation CCND1 FGF2 18404517 3089683 Positive_regulation CCND1 FGF2 18404517 3089684 Positive_regulation CCND1 FGF2 18404517 3089692 Positive_regulation CCND1 FGF2 18404517 3089693 Positive_regulation CCND1 FGF2 18404517 3089694 Positive_regulation CCND1 FGF2 18404517 3089701 Positive_regulation CCND1 FGF2 18404517 3089702 Positive_regulation CCND1 FGF2 21394106 487510 Positive_regulation CCND1 FGF2 24503018 784368 Positive_regulation CCND1 FGF2 9314544 1464269 Positive_regulation CCND1 FGF20 11257130 1268036 Positive_regulation CCND1 FGF20 11257130 1268485 Positive_regulation CCND1 FGF21 11257130 1268037 Positive_regulation CCND1 FGF21 11257130 1268486 Positive_regulation CCND1 FGF22 11257130 1268038 Positive_regulation CCND1 FGF22 11257130 1268487 Positive_regulation CCND1 FGF23 11257130 1268039 Positive_regulation CCND1 FGF23 11257130 1268488 Positive_regulation CCND1 FGF23 18678710 1354315 Positive_regulation CCND1 FGF3 11257130 1268040 Positive_regulation CCND1 FGF3 11257130 1268489 Positive_regulation CCND1 FGF4 11257130 1268041 Positive_regulation CCND1 FGF4 11257130 1268490 Positive_regulation CCND1 FGF5 11257130 1268042 Positive_regulation CCND1 FGF5 11257130 1268491 Positive_regulation CCND1 FGF6 11257130 1268043 Positive_regulation CCND1 FGF6 11257130 1268492 Positive_regulation CCND1 FGF7 11257130 1268044 Positive_regulation CCND1 FGF7 11257130 1268493 Positive_regulation CCND1 FGF8 11257130 1268045 Positive_regulation CCND1 FGF8 11257130 1268494 Positive_regulation CCND1 FGF9 11257130 1268046 Positive_regulation CCND1 FGF9 11257130 1268495 Positive_regulation CCND1 FGFR1 22731805 471647 Positive_regulation CCND1 FGFR1 24503018 784369 Positive_regulation CCND1 FHIT 24396396 844010 Positive_regulation CCND1 FHL2 19018287 2401004 Positive_regulation CCND1 FHL2 23341242 3172094 Positive_regulation CCND1 FLI1 11259090 418395 Positive_regulation CCND1 FLT3LG 21048959 2480173 Positive_regulation CCND1 FN1 11134071 1265986 Positive_regulation CCND1 FN1 11134071 1266116 Positive_regulation CCND1 FOXM1 20154714 9473 Positive_regulation CCND1 FOXM1 20208560 2129245 Positive_regulation CCND1 FOXM1 23006512 1698876 Positive_regulation CCND1 FOXO1 21209944 2492506 Positive_regulation CCND1 FOXO1 22577380 1072983 Positive_regulation CCND1 FOXO3 21179458 2488086 Positive_regulation CCND1 FOXO3 21179458 2488087 Positive_regulation CCND1 FOXO3 21179458 2488088 Positive_regulation CCND1 FOXO3 21203424 2490117 Positive_regulation CCND1 FOXO3 22815774 2665991 Positive_regulation CCND1 FOXO3 24886554 1874859 Positive_regulation CCND1 GAS1 22276155 2590228 Positive_regulation CCND1 GAS5 24884417 273067 Positive_regulation CCND1 GAST 12189559 422003 Positive_regulation CCND1 GAST 12189559 422005 Positive_regulation CCND1 GAST 15798764 425447 Positive_regulation CCND1 GATA4 23558708 3126592 Positive_regulation CCND1 GATA4 23558708 3126603 Positive_regulation CCND1 GATA4 23558708 3126604 Positive_regulation CCND1 GATA4 23558708 3126605 Positive_regulation CCND1 GDNF 24603431 2357222 Positive_regulation CCND1 GEM 24460787 1507620 Positive_regulation CCND1 GGNBP2 17407548 1846370 Positive_regulation CCND1 GGNBP2 17407548 1846375 Positive_regulation CCND1 GGNBP2 24312406 2889249 Positive_regulation CCND1 GH1 11506493 419649 Positive_regulation CCND1 GHRH 25484899 1074958 Positive_regulation CCND1 GIP 24843404 1492967 Positive_regulation CCND1 GJA1 24056538 3137243 Positive_regulation CCND1 GJA1 24056538 3137248 Positive_regulation CCND1 GJA1 24056538 3137266 Positive_regulation CCND1 GLI1 22900095 2675216 Positive_regulation CCND1 GLI1 25386960 3024905 Positive_regulation CCND1 GLI2 24550888 880110 Positive_regulation CCND1 GLIS1 24598114 1618727 Positive_regulation CCND1 GLIS2 24598114 1618726 Positive_regulation CCND1 GLIS3 24598114 1618725 Positive_regulation CCND1 GNAQ 21773036 1690234 Positive_regulation CCND1 GNAT1 25341494 475982 Positive_regulation CCND1 GNB1 25341494 475983 Positive_regulation CCND1 GNGT1 25341494 475984 Positive_regulation CCND1 GNGT2 25341494 475985 Positive_regulation CCND1 GPER1 24481325 787948 Positive_regulation CCND1 GTF2B 22792345 2663316 Positive_regulation CCND1 GTF2F1 22792345 2663317 Positive_regulation CCND1 GTF2F2 22792345 2663318 Positive_regulation CCND1 GYS1 19412162 1983376 Positive_regulation CCND1 GYS2 19412162 1983377 Positive_regulation CCND1 HACE1 23864022 1937145 Positive_regulation CCND1 HDAC1 17407548 1846394 Positive_regulation CCND1 HDAC2 17407548 1846395 Positive_regulation CCND1 HDAC2 22132221 2574632 Positive_regulation CCND1 HDAC2 22132221 2574647 Positive_regulation CCND1 HGF 22404972 528335 Positive_regulation CCND1 HGF 23091735 1079454 Positive_regulation CCND1 HGF 24708550 272607 Positive_regulation CCND1 HIST1H2AI 24371278 2097207 Positive_regulation CCND1 HIST1H3H 24858818 2973603 Positive_regulation CCND1 HIST2H2AC 23637611 2345581 Positive_regulation CCND1 HM13 24192035 751164 Positive_regulation CCND1 HNRNPD 23242178 477782 Positive_regulation CCND1 HOXB4 22915992 1714337 Positive_regulation CCND1 HOXB4 22915992 1714342 Positive_regulation CCND1 HPR 20537156 1855699 Positive_regulation CCND1 HRAS 11237392 418361 Positive_regulation CCND1 HRAS 11250701 455663 Positive_regulation CCND1 HRAS 18834508 583307 Positive_regulation CCND1 HRAS 19384426 668900 Positive_regulation CCND1 HRAS 21541658 616618 Positive_regulation CCND1 HRAS 22973520 1079380 Positive_regulation CCND1 HRAS 23750284 2801500 Positive_regulation CCND1 HRAS 24454925 2910390 Positive_regulation CCND1 HRAS 24962785 297235 Positive_regulation CCND1 HSP90AA1 25296971 2204237 Positive_regulation CCND1 ID1 24137437 2165746 Positive_regulation CCND1 ID2 22835384 624957 Positive_regulation CCND1 ID2 22835384 624958 Positive_regulation CCND1 ID2 22835384 624959 Positive_regulation CCND1 ID2 22835384 624960 Positive_regulation CCND1 ID2 22835384 624961 Positive_regulation CCND1 ID2 22835384 624965 Positive_regulation CCND1 ID2 22835384 624967 Positive_regulation CCND1 ID2 22835384 624969 Positive_regulation CCND1 ID2 22835384 624971 Positive_regulation CCND1 IFI27 11381079 1270254 Positive_regulation CCND1 IFI27 19949542 672203 Positive_regulation CCND1 IFI27 23843843 1238238 Positive_regulation CCND1 IFI27 24098526 2858085 Positive_regulation CCND1 IFI27 25486097 3032733 Positive_regulation CCND1 IGF1 17200689 1054568 Positive_regulation CCND1 IGF1 19640308 253899 Positive_regulation CCND1 IGF1 19640308 253901 Positive_regulation CCND1 IGF1 19865540 1088910 Positive_regulation CCND1 IGF1 19865540 1088914 Positive_regulation CCND1 IGF1 22312289 1094912 Positive_regulation CCND1 IGF1 24212813 498592 Positive_regulation CCND1 IGF1 25344862 2205882 Positive_regulation CCND1 IGF1 8896599 1456865 Positive_regulation CCND1 IGF1R 24904523 935564 Positive_regulation CCND1 IHH 25170300 1063247 Positive_regulation CCND1 IL8 25165728 1623141 Positive_regulation CCND1 ILK 11402061 1270965 Positive_regulation CCND1 ILK 11402061 1270969 Positive_regulation CCND1 ILK 11402061 1271015 Positive_regulation CCND1 ILK 12835312 1293326 Positive_regulation CCND1 ILK 12835312 1293375 Positive_regulation CCND1 ILK 20565980 465631 Positive_regulation CCND1 ILK 20565980 465632 Positive_regulation CCND1 ILK 24024606 314601 Positive_regulation CCND1 ILKAP 24743186 2954851 Positive_regulation CCND1 ING1 21731648 2531923 Positive_regulation CCND1 INHBA 24628936 539633 Positive_regulation CCND1 INS 22253696 2587653 Positive_regulation CCND1 INS 22799881 265313 Positive_regulation CCND1 INS 23874448 2821353 Positive_regulation CCND1 INS 24870244 1991502 Positive_regulation CCND1 INS 24870244 1991503 Positive_regulation CCND1 INS 24870244 1991513 Positive_regulation CCND1 INSR 24303367 946611 Positive_regulation CCND1 IQGAP1 23145020 2715216 Positive_regulation CCND1 IQGAP1 23145020 2715217 Positive_regulation CCND1 IRS2 21532614 12715 Positive_regulation CCND1 ISL1 21829621 2542084 Positive_regulation CCND1 ISL1 21829621 2542094 Positive_regulation CCND1 ISL1 21829621 2542109 Positive_regulation CCND1 ISL1 21829621 2542113 Positive_regulation CCND1 ISL1 21829621 2542115 Positive_regulation CCND1 JAK1 23300886 2737031 Positive_regulation CCND1 JAK2 23300886 2737032 Positive_regulation CCND1 JAK2 23382981 2747444 Positive_regulation CCND1 JAK2 24913037 273784 Positive_regulation CCND1 JAK3 23300886 2737033 Positive_regulation CCND1 JUN 11257130 1268496 Positive_regulation CCND1 JUN 16689993 1242557 Positive_regulation CCND1 JUN 20482821 1855188 Positive_regulation CCND1 JUN 20482821 1855252 Positive_regulation CCND1 JUN 20482821 1855268 Positive_regulation CCND1 JUN 20482821 1855276 Positive_regulation CCND1 JUN 22727408 265085 Positive_regulation CCND1 JUN 22727408 265086 Positive_regulation CCND1 JUN 22832488 1631058 Positive_regulation CCND1 JUN 22904645 490821 Positive_regulation CCND1 JUN 23918007 2183993 Positive_regulation CCND1 JUN 23991421 183774 Positive_regulation CCND1 JUN 24345432 474132 Positive_regulation CCND1 JUN 24345432 474151 Positive_regulation CCND1 JUN 24797581 2189705 Positive_regulation CCND1 JUNB 11560992 1520833 Positive_regulation CCND1 JUND 24171117 1151424 Positive_regulation CCND1 KIDINS220 25410904 1884359 Positive_regulation CCND1 KIDINS220 25410904 1884370 Positive_regulation CCND1 KIN 25120685 2169291 Positive_regulation CCND1 KIN 25120685 2169293 Positive_regulation CCND1 KITLG 17205132 2374321 Positive_regulation CCND1 KL 18678710 1354316 Positive_regulation CCND1 KLF4 23024650 3075915 Positive_regulation CCND1 KLF4 23344177 1905718 Positive_regulation CCND1 KLF5 20037604 8615 Positive_regulation CCND1 KLF5 20037604 8616 Positive_regulation CCND1 KLF5 20037604 8617 Positive_regulation CCND1 KLF5 20037604 8618 Positive_regulation CCND1 KLF5 20037604 8638 Positive_regulation CCND1 KLF5 20037604 8639 Positive_regulation CCND1 KLF5 20037604 8682 Positive_regulation CCND1 KLF5 20037604 8690 Positive_regulation CCND1 KLF5 20037604 8691 Positive_regulation CCND1 KLF5 20037604 8702 Positive_regulation CCND1 KLF5 20037604 8703 Positive_regulation CCND1 KLF5 24236150 2878758 Positive_regulation CCND1 KLF5 25170806 1129298 Positive_regulation CCND1 KRAS 11237392 418362 Positive_regulation CCND1 KRAS 11250701 455664 Positive_regulation CCND1 KRAS 18834508 583308 Positive_regulation CCND1 KRAS 21364589 436530 Positive_regulation CCND1 KRAS 21541658 616619 Positive_regulation CCND1 KRAS 22973520 1079381 Positive_regulation CCND1 KRAS 23750284 2801501 Positive_regulation CCND1 KRAS 24454925 2910391 Positive_regulation CCND1 KRAS 24962785 297236 Positive_regulation CCND1 KRIT1 24291398 857906 Positive_regulation CCND1 LARS2 24722568 1125993 Positive_regulation CCND1 LEF1 11604417 1275702 Positive_regulation CCND1 LEF1 16990252 2022786 Positive_regulation CCND1 LEF1 22168911 3207478 Positive_regulation CCND1 LEF1 24651473 2936584 Positive_regulation CCND1 LEP 17274833 460658 Positive_regulation CCND1 LEP 21338489 1504910 Positive_regulation CCND1 LEP 22968658 788017 Positive_regulation CCND1 LEP 23300886 2737010 Positive_regulation CCND1 LEP 23300886 2737034 Positive_regulation CCND1 LGALS3 22024187 1505609 Positive_regulation CCND1 LGALS3 24971481 549050 Positive_regulation CCND1 LGR4 24455684 186308 Positive_regulation CCND1 LMO4 19648968 2126201 Positive_regulation CCND1 LMO4 19648968 2126217 Positive_regulation CCND1 LMO4 19648968 2126230 Positive_regulation CCND1 LMO4 19648968 2126232 Positive_regulation CCND1 LMO4 19648968 2126252 Positive_regulation CCND1 LMO4 23291272 506251 Positive_regulation CCND1 LRPAP1 21494687 2513527 Positive_regulation CCND1 LRPAP1 25104955 971469 Positive_regulation CCND1 LTF 23670595 1106860 Positive_regulation CCND1 MACC1 23573286 2778090 Positive_regulation CCND1 MALT1 18764945 583283 Positive_regulation CCND1 MAP2K1 16390551 3106013 Positive_regulation CCND1 MAP2K1 17092340 580223 Positive_regulation CCND1 MAP2K1 17449939 1634797 Positive_regulation CCND1 MAP2K1 22833568 1806085 Positive_regulation CCND1 MAP2K1 23300886 2737011 Positive_regulation CCND1 MAP2K1 23300886 2737035 Positive_regulation CCND1 MAP2K1 24577313 1124464 Positive_regulation CCND1 MAP2K1 24577313 1124475 Positive_regulation CCND1 MAP2K2 16390551 3106014 Positive_regulation CCND1 MAP2K2 17092340 580224 Positive_regulation CCND1 MAP2K2 17449939 1634798 Positive_regulation CCND1 MAP2K2 22833568 1806086 Positive_regulation CCND1 MAP2K2 23300886 2737012 Positive_regulation CCND1 MAP2K2 23300886 2737036 Positive_regulation CCND1 MAP2K2 24577313 1124465 Positive_regulation CCND1 MAP2K2 24577313 1124476 Positive_regulation CCND1 MAP2K3 16390551 3106015 Positive_regulation CCND1 MAP2K3 17092340 580225 Positive_regulation CCND1 MAP2K3 17449939 1634799 Positive_regulation CCND1 MAP2K3 22833568 1806087 Positive_regulation CCND1 MAP2K3 23300886 2737013 Positive_regulation CCND1 MAP2K3 23300886 2737037 Positive_regulation CCND1 MAP2K3 24577313 1124466 Positive_regulation CCND1 MAP2K3 24577313 1124477 Positive_regulation CCND1 MAP2K4 16390551 3106016 Positive_regulation CCND1 MAP2K4 17092340 580226 Positive_regulation CCND1 MAP2K4 17449939 1634800 Positive_regulation CCND1 MAP2K4 22833568 1806088 Positive_regulation CCND1 MAP2K4 23300886 2737014 Positive_regulation CCND1 MAP2K4 23300886 2737038 Positive_regulation CCND1 MAP2K4 24577313 1124467 Positive_regulation CCND1 MAP2K4 24577313 1124478 Positive_regulation CCND1 MAP2K5 16390551 3106017 Positive_regulation CCND1 MAP2K5 17092340 580227 Positive_regulation CCND1 MAP2K5 17449939 1634801 Positive_regulation CCND1 MAP2K5 22833568 1806089 Positive_regulation CCND1 MAP2K5 23300886 2737015 Positive_regulation CCND1 MAP2K5 23300886 2737039 Positive_regulation CCND1 MAP2K5 24577313 1124468 Positive_regulation CCND1 MAP2K5 24577313 1124479 Positive_regulation CCND1 MAP2K6 16390551 3106018 Positive_regulation CCND1 MAP2K6 17092340 580228 Positive_regulation CCND1 MAP2K6 17449939 1634802 Positive_regulation CCND1 MAP2K6 22833568 1806090 Positive_regulation CCND1 MAP2K6 23300886 2737016 Positive_regulation CCND1 MAP2K6 23300886 2737040 Positive_regulation CCND1 MAP2K6 24577313 1124469 Positive_regulation CCND1 MAP2K6 24577313 1124480 Positive_regulation CCND1 MAP2K7 16390551 3106019 Positive_regulation CCND1 MAP2K7 17092340 580229 Positive_regulation CCND1 MAP2K7 17449939 1634803 Positive_regulation CCND1 MAP2K7 22833568 1806091 Positive_regulation CCND1 MAP2K7 23300886 2737017 Positive_regulation CCND1 MAP2K7 23300886 2737041 Positive_regulation CCND1 MAP2K7 24577313 1124470 Positive_regulation CCND1 MAP2K7 24577313 1124481 Positive_regulation CCND1 MAP3K5 22654913 1068293 Positive_regulation CCND1 MAPK1 11134071 1266059 Positive_regulation CCND1 MAPK1 17205132 2374322 Positive_regulation CCND1 MAPK1 17205132 2374323 Positive_regulation CCND1 MAPK1 17205132 2374378 Positive_regulation CCND1 MAPK1 19159010 1055180 Positive_regulation CCND1 MAPK1 19159010 1055287 Positive_regulation CCND1 MAPK1 19935697 2128295 Positive_regulation CCND1 MAPK1 20429916 3110349 Positive_regulation CCND1 MAPK1 21457229 451351 Positive_regulation CCND1 MAPK1 22799764 265233 Positive_regulation CCND1 MAPK1 24276377 2244711 Positive_regulation CCND1 MAPK1 25047753 240760 Positive_regulation CCND1 MAPK10 11134071 1266060 Positive_regulation CCND1 MAPK10 17205132 2374324 Positive_regulation CCND1 MAPK10 17205132 2374325 Positive_regulation CCND1 MAPK10 17205132 2374379 Positive_regulation CCND1 MAPK10 19159010 1055181 Positive_regulation CCND1 MAPK10 19159010 1055288 Positive_regulation CCND1 MAPK10 19935697 2128296 Positive_regulation CCND1 MAPK10 22799764 265234 Positive_regulation CCND1 MAPK10 24276377 2244712 Positive_regulation CCND1 MAPK10 25047753 240761 Positive_regulation CCND1 MAPK11 11134071 1266061 Positive_regulation CCND1 MAPK11 17205132 2374326 Positive_regulation CCND1 MAPK11 17205132 2374327 Positive_regulation CCND1 MAPK11 17205132 2374380 Positive_regulation CCND1 MAPK11 17407548 1846311 Positive_regulation CCND1 MAPK11 17407548 1846371 Positive_regulation CCND1 MAPK11 17407548 1846396 Positive_regulation CCND1 MAPK11 19159010 1055182 Positive_regulation CCND1 MAPK11 19159010 1055289 Positive_regulation CCND1 MAPK11 19935697 2128297 Positive_regulation CCND1 MAPK11 22799764 265235 Positive_regulation CCND1 MAPK11 24189219 1120986 Positive_regulation CCND1 MAPK11 24189219 1120989 Positive_regulation CCND1 MAPK11 24276377 2244713 Positive_regulation CCND1 MAPK11 25047753 240762 Positive_regulation CCND1 MAPK12 11134071 1266062 Positive_regulation CCND1 MAPK12 17205132 2374328 Positive_regulation CCND1 MAPK12 17205132 2374329 Positive_regulation CCND1 MAPK12 17205132 2374381 Positive_regulation CCND1 MAPK12 19159010 1055183 Positive_regulation CCND1 MAPK12 19159010 1055290 Positive_regulation CCND1 MAPK12 19935697 2128298 Positive_regulation CCND1 MAPK12 22799764 265236 Positive_regulation CCND1 MAPK12 24276377 2244714 Positive_regulation CCND1 MAPK12 25047753 240763 Positive_regulation CCND1 MAPK13 11134071 1266063 Positive_regulation CCND1 MAPK13 17205132 2374330 Positive_regulation CCND1 MAPK13 17205132 2374331 Positive_regulation CCND1 MAPK13 17205132 2374382 Positive_regulation CCND1 MAPK13 19159010 1055184 Positive_regulation CCND1 MAPK13 19159010 1055291 Positive_regulation CCND1 MAPK13 19935697 2128299 Positive_regulation CCND1 MAPK13 22799764 265237 Positive_regulation CCND1 MAPK13 24276377 2244715 Positive_regulation CCND1 MAPK13 25047753 240764 Positive_regulation CCND1 MAPK14 11134071 1266064 Positive_regulation CCND1 MAPK14 17205132 2374332 Positive_regulation CCND1 MAPK14 17205132 2374333 Positive_regulation CCND1 MAPK14 17205132 2374383 Positive_regulation CCND1 MAPK14 19159010 1055185 Positive_regulation CCND1 MAPK14 19159010 1055292 Positive_regulation CCND1 MAPK14 19935697 2128300 Positive_regulation CCND1 MAPK14 22799764 265238 Positive_regulation CCND1 MAPK14 24276377 2244716 Positive_regulation CCND1 MAPK14 25047753 240765 Positive_regulation CCND1 MAPK15 11134071 1266058 Positive_regulation CCND1 MAPK15 17205132 2374318 Positive_regulation CCND1 MAPK15 17205132 2374319 Positive_regulation CCND1 MAPK15 17205132 2374376 Positive_regulation CCND1 MAPK15 19159010 1055179 Positive_regulation CCND1 MAPK15 19159010 1055286 Positive_regulation CCND1 MAPK15 19935697 2128292 Positive_regulation CCND1 MAPK15 22799764 265231 Positive_regulation CCND1 MAPK15 24276377 2244706 Positive_regulation CCND1 MAPK15 25047753 240756 Positive_regulation CCND1 MAPK3 11134071 1266065 Positive_regulation CCND1 MAPK3 17205132 2374334 Positive_regulation CCND1 MAPK3 17205132 2374335 Positive_regulation CCND1 MAPK3 17205132 2374384 Positive_regulation CCND1 MAPK3 17315398 3208167 Positive_regulation CCND1 MAPK3 19159010 1055186 Positive_regulation CCND1 MAPK3 19159010 1055293 Positive_regulation CCND1 MAPK3 19935697 2128301 Positive_regulation CCND1 MAPK3 20429916 3110350 Positive_regulation CCND1 MAPK3 21457229 451352 Positive_regulation CCND1 MAPK3 22253905 2588317 Positive_regulation CCND1 MAPK3 22404972 528373 Positive_regulation CCND1 MAPK3 22799764 265239 Positive_regulation CCND1 MAPK3 22912841 2679579 Positive_regulation CCND1 MAPK3 23187001 219784 Positive_regulation CCND1 MAPK3 23300886 2737042 Positive_regulation CCND1 MAPK3 23561040 412389 Positive_regulation CCND1 MAPK3 24276377 2244717 Positive_regulation CCND1 MAPK3 24962785 297237 Positive_regulation CCND1 MAPK3 25047753 240766 Positive_regulation CCND1 MAPK3 25093037 1650926 Positive_regulation CCND1 MAPK4 11134071 1266066 Positive_regulation CCND1 MAPK4 17205132 2374336 Positive_regulation CCND1 MAPK4 17205132 2374337 Positive_regulation CCND1 MAPK4 17205132 2374385 Positive_regulation CCND1 MAPK4 19159010 1055187 Positive_regulation CCND1 MAPK4 19159010 1055294 Positive_regulation CCND1 MAPK4 19935697 2128302 Positive_regulation CCND1 MAPK4 22799764 265240 Positive_regulation CCND1 MAPK4 24276377 2244718 Positive_regulation CCND1 MAPK4 25047753 240767 Positive_regulation CCND1 MAPK6 11134071 1266067 Positive_regulation CCND1 MAPK6 17205132 2374338 Positive_regulation CCND1 MAPK6 17205132 2374339 Positive_regulation CCND1 MAPK6 17205132 2374386 Positive_regulation CCND1 MAPK6 19159010 1055188 Positive_regulation CCND1 MAPK6 19159010 1055295 Positive_regulation CCND1 MAPK6 19935697 2128303 Positive_regulation CCND1 MAPK6 22799764 265241 Positive_regulation CCND1 MAPK6 24276377 2244719 Positive_regulation CCND1 MAPK6 25047753 240768 Positive_regulation CCND1 MAPK7 11134071 1266068 Positive_regulation CCND1 MAPK7 17205132 2374340 Positive_regulation CCND1 MAPK7 17205132 2374341 Positive_regulation CCND1 MAPK7 17205132 2374387 Positive_regulation CCND1 MAPK7 19159010 1055189 Positive_regulation CCND1 MAPK7 19159010 1055296 Positive_regulation CCND1 MAPK7 19935697 2128304 Positive_regulation CCND1 MAPK7 22799764 265242 Positive_regulation CCND1 MAPK7 24276377 2244720 Positive_regulation CCND1 MAPK7 25047753 240769 Positive_regulation CCND1 MAPK8 11134071 1266069 Positive_regulation CCND1 MAPK8 17205132 2374342 Positive_regulation CCND1 MAPK8 17205132 2374343 Positive_regulation CCND1 MAPK8 17205132 2374388 Positive_regulation CCND1 MAPK8 19159010 1055190 Positive_regulation CCND1 MAPK8 19159010 1055297 Positive_regulation CCND1 MAPK8 19935697 2128305 Positive_regulation CCND1 MAPK8 22799764 265243 Positive_regulation CCND1 MAPK8 24276377 2244721 Positive_regulation CCND1 MAPK8 25047753 240770 Positive_regulation CCND1 MAPK9 11134071 1266070 Positive_regulation CCND1 MAPK9 17205132 2374344 Positive_regulation CCND1 MAPK9 17205132 2374345 Positive_regulation CCND1 MAPK9 17205132 2374389 Positive_regulation CCND1 MAPK9 19159010 1055191 Positive_regulation CCND1 MAPK9 19159010 1055298 Positive_regulation CCND1 MAPK9 19935697 2128306 Positive_regulation CCND1 MAPK9 22799764 265244 Positive_regulation CCND1 MAPK9 24276377 2244722 Positive_regulation CCND1 MAPK9 25047753 240771 Positive_regulation CCND1 MAPKAP1 24931005 2192343 Positive_regulation CCND1 MATK 23800081 1481050 Positive_regulation CCND1 MCTS1 23211466 2181778 Positive_regulation CCND1 MCTS1 23645982 3188954 Positive_regulation CCND1 MIF 19703290 1625531 Positive_regulation CCND1 MIF 25015194 2195708 Positive_regulation CCND1 MIR15B 24995320 194191 Positive_regulation CCND1 MIR20A 21765466 2141154 Positive_regulation CCND1 MIR31 24779718 1874219 Positive_regulation CCND1 MIR31 24779718 1874220 Positive_regulation CCND1 MIR31 24779718 1874234 Positive_regulation CCND1 MIR499A 24040263 2846295 Positive_regulation CCND1 MIR499A 24040263 2846301 Positive_regulation CCND1 MLST8 22359572 2597708 Positive_regulation CCND1 MLST8 24212820 498818 Positive_regulation CCND1 MLST8 24931005 2192344 Positive_regulation CCND1 MLXIPL 22751438 541623 Positive_regulation CCND1 MPZ 17407548 1846333 Positive_regulation CCND1 MSC 23894393 2824481 Positive_regulation CCND1 MSI1 22428049 2611396 Positive_regulation CCND1 MST1 21423209 2138730 Positive_regulation CCND1 MST1 21423209 2138731 Positive_regulation CCND1 MST1 21423209 2138732 Positive_regulation CCND1 MST1 21423209 2138734 Positive_regulation CCND1 MST1 21423209 2138735 Positive_regulation CCND1 MSX2 22457812 2614036 Positive_regulation CCND1 MSX2 22697792 471624 Positive_regulation CCND1 MSX2 23593111 2779046 Positive_regulation CCND1 MT2A 23870553 1700167 Positive_regulation CCND1 MTA1 21595884 1505333 Positive_regulation CCND1 MTOR 18652687 323945 Positive_regulation CCND1 MTOR 21049085 2120724 Positive_regulation CCND1 MTOR 21903859 787753 Positive_regulation CCND1 MTOR 22359572 2597710 Positive_regulation CCND1 MTOR 23202971 1098987 Positive_regulation CCND1 MTOR 23382981 2747443 Positive_regulation CCND1 MTOR 24212820 498820 Positive_regulation CCND1 MTOR 24276377 2244710 Positive_regulation CCND1 MTOR 24688409 3156209 Positive_regulation CCND1 MTOR 24931005 2192346 Positive_regulation CCND1 MUC1 24979278 2160473 Positive_regulation CCND1 MUC1 24979278 2160474 Positive_regulation CCND1 MUC1 24979278 2160489 Positive_regulation CCND1 MUC1 24979278 2160500 Positive_regulation CCND1 MUC1 24979278 2160520 Positive_regulation CCND1 MUC1 24979278 2160523 Positive_regulation CCND1 MYBL2 20562917 2132770 Positive_regulation CCND1 MYC 11250701 455655 Positive_regulation CCND1 MYC 23344177 1905719 Positive_regulation CCND1 MYC 23907459 564486 Positive_regulation CCND1 MYC 24972138 1128048 Positive_regulation CCND1 MYC 24972138 1128058 Positive_regulation CCND1 MYC 24991193 484739 Positive_regulation CCND1 MYC 24991193 484741 Positive_regulation CCND1 MYC 24991193 484747 Positive_regulation CCND1 MYC 25047753 240772 Positive_regulation CCND1 MYLIP 18695042 1354613 Positive_regulation CCND1 MYLIP 18695042 1354616 Positive_regulation CCND1 MYLIP 18695042 1354627 Positive_regulation CCND1 MYLIP 18695042 1354628 Positive_regulation CCND1 MYLIP 18695042 1354632 Positive_regulation CCND1 MYLIP 18695042 1354633 Positive_regulation CCND1 MYLIP 18701644 2035887 Positive_regulation CCND1 MYLIP 18701644 2035895 Positive_regulation CCND1 MYLIP 18701644 2035897 Positive_regulation CCND1 MYLIP 18701644 2035900 Positive_regulation CCND1 MYLIP 20346098 465397 Positive_regulation CCND1 MYLIP 20868483 330151 Positive_regulation CCND1 MYLIP 20885820 672586 Positive_regulation CCND1 MYLIP 21203424 2490131 Positive_regulation CCND1 MYLIP 21765466 2141153 Positive_regulation CCND1 MYLIP 22113133 469062 Positive_regulation CCND1 MYLIP 22319632 2595654 Positive_regulation CCND1 MYLIP 22389628 2278524 Positive_regulation CCND1 MYLIP 22417299 1616610 Positive_regulation CCND1 MYLIP 22564414 1397751 Positive_regulation CCND1 MYLIP 22912826 2679561 Positive_regulation CCND1 MYLIP 22912826 2679568 Positive_regulation CCND1 MYLIP 22942717 1097073 Positive_regulation CCND1 MYLIP 22942717 1097079 Positive_regulation CCND1 MYLIP 22942717 1097081 Positive_regulation CCND1 MYLIP 23284982 2731410 Positive_regulation CCND1 MYLIP 23383003 2747575 Positive_regulation CCND1 MYLIP 23383003 2747578 Positive_regulation CCND1 MYLIP 23383003 2747586 Positive_regulation CCND1 MYLIP 23383271 2749852 Positive_regulation CCND1 MYLIP 23533632 2770826 Positive_regulation CCND1 MYLIP 23558708 3126590 Positive_regulation CCND1 MYLIP 23558708 3126591 Positive_regulation CCND1 MYLIP 23558708 3126613 Positive_regulation CCND1 MYLIP 23558708 3126616 Positive_regulation CCND1 MYLIP 23668930 625727 Positive_regulation CCND1 MYLIP 23717626 2798514 Positive_regulation CCND1 MYLIP 24013378 1111758 Positive_regulation CCND1 MYLIP 24495516 1701279 Positive_regulation CCND1 MYLIP 24606633 1872828 Positive_regulation CCND1 MYLIP 24917186 273870 Positive_regulation CCND1 MYLIP 24936138 1085250 Positive_regulation CCND1 MYLIP 24936138 1085251 Positive_regulation CCND1 MYLIP 24949940 2981985 Positive_regulation CCND1 MYLIP 24995320 194182 Positive_regulation CCND1 MYLIP 24995320 194183 Positive_regulation CCND1 MYLIP 24995320 194185 Positive_regulation CCND1 MYLIP 24995320 194188 Positive_regulation CCND1 MYLIP 25013381 1063116 Positive_regulation CCND1 MYLIP 25132913 2229840 Positive_regulation CCND1 MYLIP 25361006 2206587 Positive_regulation CCND1 MYLIP 25546234 3036475 Positive_regulation CCND1 MYLIP PMC4185361 787283 Positive_regulation CCND1 NA 24962785 297226 Positive_regulation CCND1 NBN 25486524 2160770 Positive_regulation CCND1 NCOA3 24130921 204449 Positive_regulation CCND1 NDRG2 24146910 2868235 Positive_regulation CCND1 NFKB1 12633504 479921 Positive_regulation CCND1 NFKB1 12633504 479922 Positive_regulation CCND1 NFKB1 12633504 479937 Positive_regulation CCND1 NGF 22509106 1914185 Positive_regulation CCND1 NGF 22509106 1914186 Positive_regulation CCND1 NOTCH1 11266469 1269220 Positive_regulation CCND1 NOTCH1 18838555 1358280 Positive_regulation CCND1 NOTCH1 21743488 2140748 Positive_regulation CCND1 NOTCH1 24024180 183847 Positive_regulation CCND1 NOTCH1 25566499 949571 Positive_regulation CCND1 NOTCH2 18838555 1358281 Positive_regulation CCND1 NOTCH2 25566499 949572 Positive_regulation CCND1 NOTCH3 18838555 1358282 Positive_regulation CCND1 NOTCH3 21743488 2140741 Positive_regulation CCND1 NOTCH3 21743488 2140749 Positive_regulation CCND1 NOTCH3 25566499 949573 Positive_regulation CCND1 NOTCH4 18838555 1358283 Positive_regulation CCND1 NOTCH4 25566499 949574 Positive_regulation CCND1 NOX1 23864022 1937192 Positive_regulation CCND1 NOX3 23864022 1937193 Positive_regulation CCND1 NOX4 23864022 1937194 Positive_regulation CCND1 NOX5 23864022 1937191 Positive_regulation CCND1 NPM1 18625744 1551567 Positive_regulation CCND1 NQO1 24460787 1507619 Positive_regulation CCND1 NQO2 24968355 2984287 Positive_regulation CCND1 NQO2 24968355 2984304 Positive_regulation CCND1 NQO2 24968355 2984315 Positive_regulation CCND1 NQO2 24968355 2984344 Positive_regulation CCND1 NR0B1 20421209 2053460 Positive_regulation CCND1 NR0B1 23118901 2712049 Positive_regulation CCND1 NR0B1 23118901 2712059 Positive_regulation CCND1 NR0B1 25337545 1241241 Positive_regulation CCND1 NR0B1 25337545 1241253 Positive_regulation CCND1 NR5A2 25514243 1135714 Positive_regulation CCND1 NRAS 11237392 418363 Positive_regulation CCND1 NRAS 11250701 455665 Positive_regulation CCND1 NRAS 18834508 583309 Positive_regulation CCND1 NRAS 21541658 616620 Positive_regulation CCND1 NRAS 22973520 1079382 Positive_regulation CCND1 NRAS 23750284 2801502 Positive_regulation CCND1 NRAS 24454925 2910392 Positive_regulation CCND1 NRAS 24962785 297238 Positive_regulation CCND1 NRG1 22111699 334580 Positive_regulation CCND1 OGT 23029544 2698718 Positive_regulation CCND1 OGT 25000257 2160559 Positive_regulation CCND1 OPN1LW 24305655 502529 Positive_regulation CCND1 ORAI3 24058448 2847553 Positive_regulation CCND1 OSR1 24931004 1681290 Positive_regulation CCND1 PAK1 18283314 430043 Positive_regulation CCND1 PAK1 23950862 2832645 Positive_regulation CCND1 PAK1 23950862 2832647 Positive_regulation CCND1 PAK7 23685956 17649 Positive_regulation CCND1 PARP1 20531415 434940 Positive_regulation CCND1 PARP1 23586056 181332 Positive_regulation CCND1 PARP10 20531415 434935 Positive_regulation CCND1 PARP10 23586056 181327 Positive_regulation CCND1 PARP11 20531415 434932 Positive_regulation CCND1 PARP11 23586056 181323 Positive_regulation CCND1 PARP12 20531415 434933 Positive_regulation CCND1 PARP12 23586056 181325 Positive_regulation CCND1 PARP14 20531415 434944 Positive_regulation CCND1 PARP14 23586056 181336 Positive_regulation CCND1 PARP15 20531415 434938 Positive_regulation CCND1 PARP15 23586056 181330 Positive_regulation CCND1 PARP16 20531415 434936 Positive_regulation CCND1 PARP16 23586056 181328 Positive_regulation CCND1 PARP2 20531415 434942 Positive_regulation CCND1 PARP2 23586056 181334 Positive_regulation CCND1 PARP3 20531415 434943 Positive_regulation CCND1 PARP3 23586056 181335 Positive_regulation CCND1 PARP4 20531415 434941 Positive_regulation CCND1 PARP4 23586056 181333 Positive_regulation CCND1 PARP6 20531415 434939 Positive_regulation CCND1 PARP6 23586056 181331 Positive_regulation CCND1 PARP8 20531415 434937 Positive_regulation CCND1 PARP8 23586056 181329 Positive_regulation CCND1 PARP9 20531415 434934 Positive_regulation CCND1 PARP9 23586056 181326 Positive_regulation CCND1 PAX6 24454925 2910387 Positive_regulation CCND1 PBX2 15798764 425450 Positive_regulation CCND1 PCNA 17020914 2023012 Positive_regulation CCND1 PCNA 23216744 472716 Positive_regulation CCND1 PCNA 23511556 440322 Positive_regulation CCND1 PCNA 25008066 1734705 Positive_regulation CCND1 PDCD4 24157866 568413 Positive_regulation CCND1 PDGFB 21513503 291741 Positive_regulation CCND1 PDGFB 22276222 2590693 Positive_regulation CCND1 PDGFB 22500182 1156037 Positive_regulation CCND1 PDGFB 22500182 1156038 Positive_regulation CCND1 PDGFB 22500182 1156039 Positive_regulation CCND1 PDGFB 22500182 1156040 Positive_regulation CCND1 PDGFB 22675370 1156203 Positive_regulation CCND1 PDGFB 24106713 184504 Positive_regulation CCND1 PDGFB 24853429 576283 Positive_regulation CCND1 PDGFB 25187834 845135 Positive_regulation CCND1 PDLIM7 22266808 1086450 Positive_regulation CCND1 PDLIM7 24499623 1507682 Positive_regulation CCND1 PDLIM7 24499623 1507683 Positive_regulation CCND1 PDLIM7 24499623 1507684 Positive_regulation CCND1 PDLIM7 24499623 1507685 Positive_regulation CCND1 PDLIM7 24499623 1507686 Positive_regulation CCND1 PDLIM7 24499623 1507725 Positive_regulation CCND1 PDLIM7 24499623 1507726 Positive_regulation CCND1 PDLIM7 24499623 1507751 Positive_regulation CCND1 PDLIM7 24499623 1507757 Positive_regulation CCND1 PDLIM7 24499623 1507766 Positive_regulation CCND1 PDLIM7 24499623 1507767 Positive_regulation CCND1 PELP1 17525794 2013929 Positive_regulation CCND1 PER2 18334030 1489046 Positive_regulation CCND1 PHIP 23118901 2712048 Positive_regulation CCND1 PHIP 23118901 2712057 Positive_regulation CCND1 PHIP 23118901 2712058 Positive_regulation CCND1 PI3 16984645 279313 Positive_regulation CCND1 PI3 23895220 269525 Positive_regulation CCND1 PIK3C3 21132000 12234 Positive_regulation CCND1 PIK3CA 21541658 616621 Positive_regulation CCND1 PIK3CA 22665999 3129102 Positive_regulation CCND1 PIK3CA 23300886 2737018 Positive_regulation CCND1 PIK3CA 23300886 2737043 Positive_regulation CCND1 PIK3CA 23760533 907600 Positive_regulation CCND1 PIK3CA 24303367 946612 Positive_regulation CCND1 PIK3CA 24577313 1124482 Positive_regulation CCND1 PIK3CA 24578720 3177499 Positive_regulation CCND1 PIK3CA 24904527 880726 Positive_regulation CCND1 PIK3R1 21541658 616622 Positive_regulation CCND1 PIK3R1 22665999 3129103 Positive_regulation CCND1 PIK3R1 23300886 2737019 Positive_regulation CCND1 PIK3R1 23300886 2737044 Positive_regulation CCND1 PIK3R1 23760533 907601 Positive_regulation CCND1 PIK3R1 24303367 946613 Positive_regulation CCND1 PIK3R1 24577313 1124483 Positive_regulation CCND1 PIK3R1 24578720 3177500 Positive_regulation CCND1 PIK3R1 24904527 880727 Positive_regulation CCND1 PIK3R4 21132000 12235 Positive_regulation CCND1 PIN1 12631385 457633 Positive_regulation CCND1 PIN1 12631385 457636 Positive_regulation CCND1 PIN1 12631385 457639 Positive_regulation CCND1 PIN1 21219594 3178231 Positive_regulation CCND1 PIN1 21219594 3178232 Positive_regulation CCND1 PIN1 21219594 3178258 Positive_regulation CCND1 PIN1 25160749 1234596 Positive_regulation CCND1 PIN1 25160749 1234598 Positive_regulation CCND1 PIN1 25160749 1234600 Positive_regulation CCND1 PINX1 24268029 1870338 Positive_regulation CCND1 PITX2 21902831 3160612 Positive_regulation CCND1 PITX2 23316168 960784 Positive_regulation CCND1 PKM 22056988 1987979 Positive_regulation CCND1 PKM 22056988 1987992 Positive_regulation CCND1 PKM 23070542 542310 Positive_regulation CCND1 PKM 23070542 542328 Positive_regulation CCND1 PKM 23178880 1928808 Positive_regulation CCND1 PLAC1 24304549 270627 Positive_regulation CCND1 PLN 25609920 744467 Positive_regulation CCND1 PLN 25609920 744468 Positive_regulation CCND1 PLN 25632222 745021 Positive_regulation CCND1 PML 15837800 1319961 Positive_regulation CCND1 POLDIP2 17407548 1846393 Positive_regulation CCND1 POLR2A 22792345 2663319 Positive_regulation CCND1 POLR2B 22792345 2663320 Positive_regulation CCND1 POLR2C 22792345 2663321 Positive_regulation CCND1 POLR2D 22792345 2663322 Positive_regulation CCND1 POLR2E 22792345 2663323 Positive_regulation CCND1 POLR2F 22792345 2663324 Positive_regulation CCND1 POLR2G 22792345 2663325 Positive_regulation CCND1 POLR2H 22792345 2663326 Positive_regulation CCND1 POLR2I 22792345 2663327 Positive_regulation CCND1 POLR2J 22792345 2663328 Positive_regulation CCND1 POLR2K 22792345 2663329 Positive_regulation CCND1 POLR2L 22792345 2663330 Positive_regulation CCND1 POU5F1 23433354 267899 Positive_regulation CCND1 POU5F1 24946789 840741 Positive_regulation CCND1 POU5F1 24946789 840745 Positive_regulation CCND1 PRDX2 16503970 1845083 Positive_regulation CCND1 PRDX2 16503970 1845086 Positive_regulation CCND1 PRDX2 16503970 1845087 Positive_regulation CCND1 PRDX2 16503970 1845088 Positive_regulation CCND1 PRDX2 16503970 1845094 Positive_regulation CCND1 PRDX2 16504004 1845105 Positive_regulation CCND1 PRDX2 16504004 1845106 Positive_regulation CCND1 PRDX2 16504004 1845107 Positive_regulation CCND1 PRDX2 16504004 1845108 Positive_regulation CCND1 PRDX2 16504004 1845109 Positive_regulation CCND1 PRDX2 16504004 1845110 Positive_regulation CCND1 PRDX2 16504004 1845111 Positive_regulation CCND1 PRDX2 16504004 1845112 Positive_regulation CCND1 PRDX2 16504004 1845113 Positive_regulation CCND1 PRDX2 16504004 1845124 Positive_regulation CCND1 PRDX2 16504004 1845127 Positive_regulation CCND1 PRDX2 16504004 1845128 Positive_regulation CCND1 PRDX2 16504004 1845129 Positive_regulation CCND1 PRDX2 16504004 1845135 Positive_regulation CCND1 PRDX2 16504004 1845136 Positive_regulation CCND1 PRDX2 16504004 1845137 Positive_regulation CCND1 PRDX2 16504004 1845175 Positive_regulation CCND1 PRDX2 16504004 1845176 Positive_regulation CCND1 PRDX2 16504004 1845177 Positive_regulation CCND1 PRDX2 16504004 1845178 Positive_regulation CCND1 PRDX2 16504004 1845182 Positive_regulation CCND1 PRDX2 16504004 1845183 Positive_regulation CCND1 PRDX2 16504004 1845184 Positive_regulation CCND1 PRDX2 16504004 1845188 Positive_regulation CCND1 PRDX2 16504004 1845189 Positive_regulation CCND1 PRDX2 16504004 1845190 Positive_regulation CCND1 PRDX2 16504004 1845191 Positive_regulation CCND1 PRDX2 16504004 1845195 Positive_regulation CCND1 PRDX2 16504004 1845196 Positive_regulation CCND1 PRDX2 16504004 1845200 Positive_regulation CCND1 PRDX2 16504004 1845201 Positive_regulation CCND1 PRDX2 16504004 1845205 Positive_regulation CCND1 PRDX2 17407548 1846282 Positive_regulation CCND1 PRDX2 17407548 1846315 Positive_regulation CCND1 PRDX2 17407548 1846336 Positive_regulation CCND1 PRDX2 17407548 1846339 Positive_regulation CCND1 PRDX2 17407548 1846391 Positive_regulation CCND1 PRINS 23344029 1101025 Positive_regulation CCND1 PRKAA1 24505341 2920670 Positive_regulation CCND1 PRKAA2 24505341 2920671 Positive_regulation CCND1 PRKAB1 24505341 2920672 Positive_regulation CCND1 PRKAB2 24505341 2920673 Positive_regulation CCND1 PRKAG1 24505341 2920674 Positive_regulation CCND1 PRKAG2 24505341 2920675 Positive_regulation CCND1 PRL 16677418 459801 Positive_regulation CCND1 PRL 16677418 459823 Positive_regulation CCND1 PRL 17338830 460725 Positive_regulation CCND1 PRL 19808898 787709 Positive_regulation CCND1 PRL 22276155 2590210 Positive_regulation CCND1 PRL 24913037 273785 Positive_regulation CCND1 PRLR 11381079 1270249 Positive_regulation CCND1 PSEN1 11266469 1269221 Positive_regulation CCND1 PSMA1 16504004 1845138 Positive_regulation CCND1 PSMA2 16504004 1845139 Positive_regulation CCND1 PSMA5 16504004 1845140 Positive_regulation CCND1 PSMA7 16504004 1845141 Positive_regulation CCND1 PSMB1 16504004 1845142 Positive_regulation CCND1 PSMB10 16504004 1845143 Positive_regulation CCND1 PSMB2 16504004 1845144 Positive_regulation CCND1 PSMB3 16504004 1845145 Positive_regulation CCND1 PSMB6 16504004 1845146 Positive_regulation CCND1 PSMB7 16504004 1845147 Positive_regulation CCND1 PSMB8 16504004 1845148 Positive_regulation CCND1 PSMB9 16504004 1845149 Positive_regulation CCND1 PSMC1 16504004 1845150 Positive_regulation CCND1 PSMC2 16504004 1845151 Positive_regulation CCND1 PSMC3 16504004 1845152 Positive_regulation CCND1 PSMC4 16504004 1845153 Positive_regulation CCND1 PSMC5 16504004 1845154 Positive_regulation CCND1 PSMC6 16504004 1845155 Positive_regulation CCND1 PSMD1 16504004 1845156 Positive_regulation CCND1 PSMD10 16504004 1845157 Positive_regulation CCND1 PSMD12 16504004 1845158 Positive_regulation CCND1 PSMD13 16504004 1845159 Positive_regulation CCND1 PSMD2 16504004 1845160 Positive_regulation CCND1 PSMD4 16504004 1845161 Positive_regulation CCND1 PSMD5 16504004 1845162 Positive_regulation CCND1 PSMD6 16504004 1845163 Positive_regulation CCND1 PSMD7 16504004 1845164 Positive_regulation CCND1 PSMD8 16504004 1845165 Positive_regulation CCND1 PSMD9 16504004 1845166 Positive_regulation CCND1 PSME1 16504004 1845167 Positive_regulation CCND1 PSME2 16504004 1845168 Positive_regulation CCND1 PSME3 16504004 1845169 Positive_regulation CCND1 PSME3 24281003 442578 Positive_regulation CCND1 PSMF1 16504004 1845170 Positive_regulation CCND1 PTEN 11402061 1270966 Positive_regulation CCND1 PTEN 19884989 3075009 Positive_regulation CCND1 PTEN 21904669 799054 Positive_regulation CCND1 PTEN 25009983 2987606 Positive_regulation CCND1 PTEN 25009983 2987651 Positive_regulation CCND1 PTGS2 17206280 2374498 Positive_regulation CCND1 PTGS2 21152316 1090436 Positive_regulation CCND1 PTHLH 24286177 130762 Positive_regulation CCND1 RAC1 20154721 2128996 Positive_regulation CCND1 RAC1 22225989 405883 Positive_regulation CCND1 RAC1 22443473 1865323 Positive_regulation CCND1 RAC1 23864022 1937148 Positive_regulation CCND1 RAC1 23864022 1937185 Positive_regulation CCND1 RAC1 23864022 1937195 Positive_regulation CCND1 RAC1 25610373 872964 Positive_regulation CCND1 RAC2 11435472 1519652 Positive_regulation CCND1 RAC2 22225989 405884 Positive_regulation CCND1 RAC3 22225989 405885 Positive_regulation CCND1 RAD1 25409181 3028379 Positive_regulation CCND1 RAD1 25409181 3028380 Positive_regulation CCND1 RAD1 25409181 3028381 Positive_regulation CCND1 RAD1 25409181 3028441 Positive_regulation CCND1 RAD1 25409181 3028507 Positive_regulation CCND1 RAD1 25409181 3028521 Positive_regulation CCND1 RAD1 25409181 3028535 Positive_regulation CCND1 RAD1 25409181 3028557 Positive_regulation CCND1 RAD17 25409181 3028382 Positive_regulation CCND1 RAD17 25409181 3028383 Positive_regulation CCND1 RAD17 25409181 3028384 Positive_regulation CCND1 RAD17 25409181 3028442 Positive_regulation CCND1 RAD17 25409181 3028508 Positive_regulation CCND1 RAD17 25409181 3028522 Positive_regulation CCND1 RAD17 25409181 3028536 Positive_regulation CCND1 RAD17 25409181 3028558 Positive_regulation CCND1 RAD18 25409181 3028376 Positive_regulation CCND1 RAD18 25409181 3028377 Positive_regulation CCND1 RAD18 25409181 3028378 Positive_regulation CCND1 RAD18 25409181 3028440 Positive_regulation CCND1 RAD18 25409181 3028506 Positive_regulation CCND1 RAD18 25409181 3028520 Positive_regulation CCND1 RAD18 25409181 3028534 Positive_regulation CCND1 RAD18 25409181 3028556 Positive_regulation CCND1 RAD21 25409181 3028385 Positive_regulation CCND1 RAD21 25409181 3028386 Positive_regulation CCND1 RAD21 25409181 3028387 Positive_regulation CCND1 RAD21 25409181 3028443 Positive_regulation CCND1 RAD21 25409181 3028509 Positive_regulation CCND1 RAD21 25409181 3028523 Positive_regulation CCND1 RAD21 25409181 3028537 Positive_regulation CCND1 RAD21 25409181 3028559 Positive_regulation CCND1 RAD50 25409181 3028388 Positive_regulation CCND1 RAD50 25409181 3028389 Positive_regulation CCND1 RAD50 25409181 3028390 Positive_regulation CCND1 RAD50 25409181 3028444 Positive_regulation CCND1 RAD50 25409181 3028510 Positive_regulation CCND1 RAD50 25409181 3028524 Positive_regulation CCND1 RAD50 25409181 3028538 Positive_regulation CCND1 RAD50 25409181 3028560 Positive_regulation CCND1 RAD51 25409181 3028391 Positive_regulation CCND1 RAD51 25409181 3028392 Positive_regulation CCND1 RAD51 25409181 3028393 Positive_regulation CCND1 RAD51 25409181 3028445 Positive_regulation CCND1 RAD51 25409181 3028511 Positive_regulation CCND1 RAD51 25409181 3028525 Positive_regulation CCND1 RAD51 25409181 3028539 Positive_regulation CCND1 RAD51 25409181 3028561 Positive_regulation CCND1 RAD52 25409181 3028394 Positive_regulation CCND1 RAD52 25409181 3028395 Positive_regulation CCND1 RAD52 25409181 3028396 Positive_regulation CCND1 RAD52 25409181 3028446 Positive_regulation CCND1 RAD52 25409181 3028512 Positive_regulation CCND1 RAD52 25409181 3028526 Positive_regulation CCND1 RAD52 25409181 3028540 Positive_regulation CCND1 RAD52 25409181 3028562 Positive_regulation CCND1 RALB 21714887 482230 Positive_regulation CCND1 RALB 21714887 482250 Positive_regulation CCND1 RANBP9 24312406 2889205 Positive_regulation CCND1 RANBP9 24312406 2889215 Positive_regulation CCND1 RANBP9 24312406 2889216 Positive_regulation CCND1 RANBP9 24312406 2889223 Positive_regulation CCND1 RANBP9 24312406 2889224 Positive_regulation CCND1 RANBP9 24312406 2889225 Positive_regulation CCND1 RANBP9 24312406 2889230 Positive_regulation CCND1 RANBP9 24312406 2889259 Positive_regulation CCND1 RASSF1 17692468 157389 Positive_regulation CCND1 RASSF1 20825665 403124 Positive_regulation CCND1 RASSF1 22548173 1831167 Positive_regulation CCND1 RB1 10682682 416341 Positive_regulation CCND1 RB1 20184742 255417 Positive_regulation CCND1 RB1 20224733 1055950 Positive_regulation CCND1 RB1 23672832 1676183 Positive_regulation CCND1 RB1 7640224 444113 Positive_regulation CCND1 RB1 8175885 1445647 Positive_regulation CCND1 RB1 8175885 1445674 Positive_regulation CCND1 RB1 8175885 1445675 Positive_regulation CCND1 RB1 8175885 1445679 Positive_regulation CCND1 RBBP4 17407548 1846397 Positive_regulation CCND1 RBBP7 17407548 1846398 Positive_regulation CCND1 RBL1 23624932 773226 Positive_regulation CCND1 RBP2 25015565 2195814 Positive_regulation CCND1 RBP2 25015565 2195815 Positive_regulation CCND1 RELA 22541644 3161055 Positive_regulation CCND1 RHO 16776827 3107313 Positive_regulation CCND1 RHO 16776827 3107315 Positive_regulation CCND1 RHO 19730435 785915 Positive_regulation CCND1 RHO 22225989 405882 Positive_regulation CCND1 RHO 23204112 1620011 Positive_regulation CCND1 RHO 25015194 2195707 Positive_regulation CCND1 RHO 25610373 872963 Positive_regulation CCND1 RHOA 11134071 1265987 Positive_regulation CCND1 RHOA 16776827 3107316 Positive_regulation CCND1 RHOA 24662938 503499 Positive_regulation CCND1 RHOC 23145020 2715218 Positive_regulation CCND1 RHOC 23145020 2715219 Positive_regulation CCND1 RICTOR 24931005 2192345 Positive_regulation CCND1 RNF146 24454854 2910148 Positive_regulation CCND1 RNF146 24454854 2910179 Positive_regulation CCND1 RNF146 24454854 2910180 Positive_regulation CCND1 RNF146 24454854 2910189 Positive_regulation CCND1 RNF19A 17407548 1846369 Positive_regulation CCND1 RNF19A 17407548 1846392 Positive_regulation CCND1 RNF19A 22404972 528362 Positive_regulation CCND1 RNF19A 24189219 1120988 Positive_regulation CCND1 ROCK1 23204112 1620012 Positive_regulation CCND1 ROCK2 23204112 1620013 Positive_regulation CCND1 RPAP1 22792345 2663314 Positive_regulation CCND1 RPTOR 22359572 2597709 Positive_regulation CCND1 RPTOR 24212820 498819 Positive_regulation CCND1 RUNX2 20726009 161284 Positive_regulation CCND1 RUNX2 24191129 737567 Positive_regulation CCND1 S100A8 25015565 2195817 Positive_regulation CCND1 S100A9 22860097 2671581 Positive_regulation CCND1 SENP1 24970135 207830 Positive_regulation CCND1 SENP1 24970135 207831 Positive_regulation CCND1 SENP1 24970135 207834 Positive_regulation CCND1 SHH 18811955 301871 Positive_regulation CCND1 SHH 19471603 1909216 Positive_regulation CCND1 SHH 21042410 2479607 Positive_regulation CCND1 SHH 22799764 265245 Positive_regulation CCND1 SHH 24451143 1123294 Positive_regulation CCND1 SIX1 23527134 2769582 Positive_regulation CCND1 SIX1 23527134 2769583 Positive_regulation CCND1 SIX1 23527134 2769587 Positive_regulation CCND1 SIX1 23527134 2769588 Positive_regulation CCND1 SIX1 23527134 2769591 Positive_regulation CCND1 SKIV2L 24970170 208654 Positive_regulation CCND1 SKP1 17205132 2374353 Positive_regulation CCND1 SKP2 16504004 1845122 Positive_regulation CCND1 SKP2 17205132 2374358 Positive_regulation CCND1 SLC12A9 16879721 1163604 Positive_regulation CCND1 SLC12A9 22481926 1673475 Positive_regulation CCND1 SLC12A9 25477755 657794 Positive_regulation CCND1 SLC20A1 19808898 787707 Positive_regulation CCND1 SLC20A1 19808898 787708 Positive_regulation CCND1 SLC30A9 17344318 2026691 Positive_regulation CCND1 SLC30A9 17344318 2026699 Positive_regulation CCND1 SLC30A9 17344318 2026701 Positive_regulation CCND1 SLPI 14641912 3095611 Positive_regulation CCND1 SLPI 18501024 1655516 Positive_regulation CCND1 SNAI1 19124656 1553538 Positive_regulation CCND1 SOX17 19479035 2417338 Positive_regulation CCND1 SOX17 19479035 2417356 Positive_regulation CCND1 SOX17 19479035 2417363 Positive_regulation CCND1 SOX17 19479035 2417392 Positive_regulation CCND1 SOX17 19479035 2417435 Positive_regulation CCND1 SOX17 19479035 2417455 Positive_regulation CCND1 SOX2 24946789 840740 Positive_regulation CCND1 SOX2 24946789 840744 Positive_regulation CCND1 SOX6 24040263 2846300 Positive_regulation CCND1 SOX6 24040263 2846304 Positive_regulation CCND1 SOX6 24040263 2846307 Positive_regulation CCND1 SOX6 24040263 2846309 Positive_regulation CCND1 SOX6 25023649 1702328 Positive_regulation CCND1 SOX9 17698607 1343188 Positive_regulation CCND1 SOX9 17698607 1343221 Positive_regulation CCND1 SOX9 19725955 302682 Positive_regulation CCND1 SP1 20224733 1055949 Positive_regulation CCND1 SP1 21554733 404871 Positive_regulation CCND1 SP1 22911796 2676660 Positive_regulation CCND1 SPHK1 22563011 1033702 Positive_regulation CCND1 SPRY1 20813052 1858379 Positive_regulation CCND1 SPRY1 23554919 2774043 Positive_regulation CCND1 SPRY1 23554919 2774044 Positive_regulation CCND1 SRC 22276155 2590222 Positive_regulation CCND1 SRC 22276155 2590230 Positive_regulation CCND1 SRC 22276155 2590232 Positive_regulation CCND1 SRC 22927910 2680873 Positive_regulation CCND1 SRC 22927910 2680874 Positive_regulation CCND1 SRC 22927910 2680957 Positive_regulation CCND1 SRC 22927910 2680982 Positive_regulation CCND1 SRC 22927910 2681023 Positive_regulation CCND1 SRC 23098208 472603 Positive_regulation CCND1 SRC 24137325 2165457 Positive_regulation CCND1 SRC 24137325 2165458 Positive_regulation CCND1 SRC 24137325 2165465 Positive_regulation CCND1 SRC 24743777 504261 Positive_regulation CCND1 SRF 21554733 404872 Positive_regulation CCND1 STAT3 19523218 1625346 Positive_regulation CCND1 STAT3 20712901 1858172 Positive_regulation CCND1 STAT3 21486470 286595 Positive_regulation CCND1 STAT3 21486470 286596 Positive_regulation CCND1 STAT3 21559255 1673145 Positive_regulation CCND1 STAT3 22216901 1698089 Positive_regulation CCND1 STAT3 22348037 2596576 Positive_regulation CCND1 STAT3 22754280 1224441 Positive_regulation CCND1 STAT3 22973518 1079312 Positive_regulation CCND1 STAT3 23061049 941349 Positive_regulation CCND1 STAT3 23426146 2163684 Positive_regulation CCND1 STAT3 23874455 2821374 Positive_regulation CCND1 STAT3 24199193 184786 Positive_regulation CCND1 STAT3 24499623 1507678 Positive_regulation CCND1 STAT3 24499623 1507679 Positive_regulation CCND1 STAT3 24499623 1507680 Positive_regulation CCND1 STAT3 24499623 1507681 Positive_regulation CCND1 STAT3 24499623 1507722 Positive_regulation CCND1 STAT3 24499623 1507723 Positive_regulation CCND1 STAT3 24499623 1507724 Positive_regulation CCND1 STAT3 24662938 503498 Positive_regulation CCND1 STAT3 24743777 504262 Positive_regulation CCND1 STAT3 24743778 504388 Positive_regulation CCND1 STAT3 24743778 504389 Positive_regulation CCND1 STAT3 24995504 504908 Positive_regulation CCND1 STAT3 25143751 645500 Positive_regulation CCND1 STAT3 25337545 1241246 Positive_regulation CCND1 STAT5A 19242540 2406323 Positive_regulation CCND1 STAT5A 19630967 464600 Positive_regulation CCND1 STAT5A 22276155 2590209 Positive_regulation CCND1 STAT5A 22276155 2590220 Positive_regulation CCND1 STAT5A 22315972 470734 Positive_regulation CCND1 STAT5A 22919439 2224662 Positive_regulation CCND1 STAT5A 22927910 2680875 Positive_regulation CCND1 STAT5A 22927910 2680876 Positive_regulation CCND1 STAT5A 22927910 2680945 Positive_regulation CCND1 STAT5A 22927910 2680963 Positive_regulation CCND1 STAT5A 24913037 273783 Positive_regulation CCND1 STAT5B 19630967 464601 Positive_regulation CCND1 STAT5B 22485142 2616770 Positive_regulation CCND1 STC2 23187001 219773 Positive_regulation CCND1 STC2 23187001 219774 Positive_regulation CCND1 STC2 23187001 219783 Positive_regulation CCND1 STK11 23861764 2819809 Positive_regulation CCND1 STS 24739942 2953671 Positive_regulation CCND1 SUMO2 24971752 2984955 Positive_regulation CCND1 SYT1 22432006 2611509 Positive_regulation CCND1 SYT1 22541644 3161054 Positive_regulation CCND1 SYT1 23402310 482996 Positive_regulation CCND1 SYT1 25412312 579215 Positive_regulation CCND1 TAB2 18764945 583282 Positive_regulation CCND1 TCEA1 20657652 2456289 Positive_regulation CCND1 TCF12 16990252 2022775 Positive_regulation CCND1 TCF12 19479035 2417384 Positive_regulation CCND1 TCF12 19826421 432881 Positive_regulation CCND1 TCF12 23864022 1937136 Positive_regulation CCND1 TCF12 24245549 2221630 Positive_regulation CCND1 TCF12 24656144 539693 Positive_regulation CCND1 TCF12 24979278 2160451 Positive_regulation CCND1 TCF12 24979278 2160452 Positive_regulation CCND1 TCF15 16990252 2022776 Positive_regulation CCND1 TCF15 19479035 2417385 Positive_regulation CCND1 TCF15 19826421 432882 Positive_regulation CCND1 TCF15 23864022 1937137 Positive_regulation CCND1 TCF15 24245549 2221631 Positive_regulation CCND1 TCF15 24656144 539694 Positive_regulation CCND1 TCF15 24979278 2160453 Positive_regulation CCND1 TCF15 24979278 2160454 Positive_regulation CCND1 TCF19 16990252 2022777 Positive_regulation CCND1 TCF19 19479035 2417386 Positive_regulation CCND1 TCF19 19826421 432883 Positive_regulation CCND1 TCF19 23864022 1937138 Positive_regulation CCND1 TCF19 24245549 2221632 Positive_regulation CCND1 TCF19 24656144 539695 Positive_regulation CCND1 TCF19 24979278 2160455 Positive_regulation CCND1 TCF19 24979278 2160456 Positive_regulation CCND1 TCF20 16990252 2022778 Positive_regulation CCND1 TCF20 19479035 2417387 Positive_regulation CCND1 TCF20 19826421 432884 Positive_regulation CCND1 TCF20 23864022 1937139 Positive_regulation CCND1 TCF20 24245549 2221633 Positive_regulation CCND1 TCF20 24656144 539696 Positive_regulation CCND1 TCF20 24979278 2160457 Positive_regulation CCND1 TCF20 24979278 2160458 Positive_regulation CCND1 TCF21 16990252 2022779 Positive_regulation CCND1 TCF21 19479035 2417388 Positive_regulation CCND1 TCF21 19826421 432885 Positive_regulation CCND1 TCF21 23864022 1937140 Positive_regulation CCND1 TCF21 24245549 2221634 Positive_regulation CCND1 TCF21 24656144 539697 Positive_regulation CCND1 TCF21 24979278 2160459 Positive_regulation CCND1 TCF21 24979278 2160460 Positive_regulation CCND1 TCF23 16990252 2022783 Positive_regulation CCND1 TCF23 19479035 2417393 Positive_regulation CCND1 TCF23 19826421 432889 Positive_regulation CCND1 TCF23 23864022 1937144 Positive_regulation CCND1 TCF23 24245549 2221638 Positive_regulation CCND1 TCF23 24656144 539701 Positive_regulation CCND1 TCF23 24979278 2160467 Positive_regulation CCND1 TCF23 24979278 2160468 Positive_regulation CCND1 TCF24 16990252 2022785 Positive_regulation CCND1 TCF24 19479035 2417395 Positive_regulation CCND1 TCF24 19826421 432891 Positive_regulation CCND1 TCF24 23864022 1937147 Positive_regulation CCND1 TCF24 24245549 2221640 Positive_regulation CCND1 TCF24 24656144 539703 Positive_regulation CCND1 TCF24 24979278 2160471 Positive_regulation CCND1 TCF24 24979278 2160472 Positive_regulation CCND1 TCF25 16990252 2022784 Positive_regulation CCND1 TCF25 19479035 2417394 Positive_regulation CCND1 TCF25 19826421 432890 Positive_regulation CCND1 TCF25 23864022 1937146 Positive_regulation CCND1 TCF25 24245549 2221639 Positive_regulation CCND1 TCF25 24656144 539702 Positive_regulation CCND1 TCF25 24979278 2160469 Positive_regulation CCND1 TCF25 24979278 2160470 Positive_regulation CCND1 TCF3 16990252 2022780 Positive_regulation CCND1 TCF3 19479035 2417389 Positive_regulation CCND1 TCF3 19826421 432886 Positive_regulation CCND1 TCF3 23864022 1937141 Positive_regulation CCND1 TCF3 24245549 2221635 Positive_regulation CCND1 TCF3 24656144 539698 Positive_regulation CCND1 TCF3 24979278 2160461 Positive_regulation CCND1 TCF3 24979278 2160462 Positive_regulation CCND1 TCF4 16990252 2022781 Positive_regulation CCND1 TCF4 19479035 2417390 Positive_regulation CCND1 TCF4 19826421 432887 Positive_regulation CCND1 TCF4 23864022 1937142 Positive_regulation CCND1 TCF4 24245549 2221636 Positive_regulation CCND1 TCF4 24656144 539699 Positive_regulation CCND1 TCF4 24979278 2160463 Positive_regulation CCND1 TCF4 24979278 2160464 Positive_regulation CCND1 TCF7 16990252 2022782 Positive_regulation CCND1 TCF7 19479035 2417391 Positive_regulation CCND1 TCF7 19826421 432888 Positive_regulation CCND1 TCF7 23864022 1937143 Positive_regulation CCND1 TCF7 24245549 2221637 Positive_regulation CCND1 TCF7 24656144 539700 Positive_regulation CCND1 TCF7 24979278 2160465 Positive_regulation CCND1 TCF7 24979278 2160466 Positive_regulation CCND1 TCF7L2 20548773 2452673 Positive_regulation CCND1 TCF7L2 23690679 742664 Positive_regulation CCND1 TEAD1 23720711 944263 Positive_regulation CCND1 TEAD2 23720711 944264 Positive_regulation CCND1 TEAD3 23720711 944265 Positive_regulation CCND1 TEAD4 23720711 944266 Positive_regulation CCND1 TFPT 24348764 843895 Positive_regulation CCND1 TMED7 11259090 418392 Positive_regulation CCND1 TMED7 11425869 1271736 Positive_regulation CCND1 TMED7 17092340 580215 Positive_regulation CCND1 TMED7 21209944 2492500 Positive_regulation CCND1 TMED7 23511556 440338 Positive_regulation CCND1 TNF 16987412 384045 Positive_regulation CCND1 TNF 16987412 384046 Positive_regulation CCND1 TNF 21221075 1717672 Positive_regulation CCND1 TNF 22768286 2660448 Positive_regulation CCND1 TNF 24013271 2842017 Positive_regulation CCND1 TNF 24016040 294970 Positive_regulation CCND1 TNF 24350291 185952 Positive_regulation CCND1 TNFSF12 20953353 1748391 Positive_regulation CCND1 TOB1 22158108 14204 Positive_regulation CCND1 TOB1 22158108 14211 Positive_regulation CCND1 TP53 11161387 418289 Positive_regulation CCND1 TP53 18237383 250708 Positive_regulation CCND1 TP53 22548705 1865876 Positive_regulation CCND1 TP53 23164821 1901011 Positive_regulation CCND1 TP53 23344177 1905716 Positive_regulation CCND1 TP53 23555779 2775307 Positive_regulation CCND1 TRAF6 18764945 583280 Positive_regulation CCND1 TRO 24091475 2184958 Positive_regulation CCND1 TSC22D3 19814803 1852031 Positive_regulation CCND1 TTC37 24970170 208655 Positive_regulation CCND1 TYR 22927910 2680983 Positive_regulation CCND1 TYR 24137325 2165466 Positive_regulation CCND1 UBE2V1 18764945 583281 Positive_regulation CCND1 UFL1 21494687 2513526 Positive_regulation CCND1 UFL1 25104955 971468 Positive_regulation CCND1 URGCP 24592121 657521 Positive_regulation CCND1 USP2 22069692 3183439 Positive_regulation CCND1 USP2 23236372 2726026 Positive_regulation CCND1 USP2 23236372 2726029 Positive_regulation CCND1 USP2 25121098 196518 Positive_regulation CCND1 VEGFA 25285016 2123511 Positive_regulation CCND1 VEGFC 25289059 845217 Positive_regulation CCND1 VEGFC 25289059 845231 Positive_regulation CCND1 VRK1 21179456 2488002 Positive_regulation CCND1 VRK1 21346188 1788593 Positive_regulation CCND1 VRK1 25310002 3014938 Positive_regulation CCND1 WDR61 24970170 208656 Positive_regulation CCND1 WNK1 22835384 624968 Positive_regulation CCND1 WNT1 11739413 1277240 Positive_regulation CCND1 WNT1 18218096 281105 Positive_regulation CCND1 WNT1 20459685 1854901 Positive_regulation CCND1 WNT1 20565980 465630 Positive_regulation CCND1 WNT1 20802536 2135932 Positive_regulation CCND1 WNT1 21888663 174580 Positive_regulation CCND1 WNT1 22298956 1059687 Positive_regulation CCND1 WNT1 22889244 1506462 Positive_regulation CCND1 WNT1 23772418 945462 Positive_regulation CCND1 WNT1 23844215 2819607 Positive_regulation CCND1 WNT1 24136230 568123 Positive_regulation CCND1 WNT1 24256736 1700929 Positive_regulation CCND1 WNT1 24324366 1084928 Positive_regulation CCND1 WNT1 24999833 2986685 Positive_regulation CCND1 WNT1 25386960 3024898 Positive_regulation CCND1 WNT1 25393427 3026800 Positive_regulation CCND1 WNT11 11739413 1277241 Positive_regulation CCND1 WNT11 18218096 281106 Positive_regulation CCND1 WNT11 20459685 1854902 Positive_regulation CCND1 WNT11 20802536 2135933 Positive_regulation CCND1 WNT11 21888663 174581 Positive_regulation CCND1 WNT11 22298956 1059688 Positive_regulation CCND1 WNT11 22889244 1506463 Positive_regulation CCND1 WNT11 23772418 945463 Positive_regulation CCND1 WNT11 23844215 2819608 Positive_regulation CCND1 WNT11 24256736 1700930 Positive_regulation CCND1 WNT11 24324366 1084929 Positive_regulation CCND1 WNT11 24999833 2986686 Positive_regulation CCND1 WNT11 25386960 3024899 Positive_regulation CCND1 WNT11 25393427 3026801 Positive_regulation CCND1 WNT16 11739413 1277246 Positive_regulation CCND1 WNT16 18218096 281111 Positive_regulation CCND1 WNT16 20459685 1854907 Positive_regulation CCND1 WNT16 20802536 2135938 Positive_regulation CCND1 WNT16 21888663 174586 Positive_regulation CCND1 WNT16 22298956 1059693 Positive_regulation CCND1 WNT16 22889244 1506468 Positive_regulation CCND1 WNT16 23772418 945468 Positive_regulation CCND1 WNT16 23844215 2819613 Positive_regulation CCND1 WNT16 24256736 1700935 Positive_regulation CCND1 WNT16 24324366 1084934 Positive_regulation CCND1 WNT16 24999833 2986691 Positive_regulation CCND1 WNT16 25386960 3024904 Positive_regulation CCND1 WNT16 25393427 3026806 Positive_regulation CCND1 WNT2 11739413 1277242 Positive_regulation CCND1 WNT2 18218096 281107 Positive_regulation CCND1 WNT2 20459685 1854903 Positive_regulation CCND1 WNT2 20802536 2135934 Positive_regulation CCND1 WNT2 21888663 174582 Positive_regulation CCND1 WNT2 22298956 1059689 Positive_regulation CCND1 WNT2 22889244 1506464 Positive_regulation CCND1 WNT2 23772418 945464 Positive_regulation CCND1 WNT2 23844215 2819609 Positive_regulation CCND1 WNT2 24256736 1700931 Positive_regulation CCND1 WNT2 24324366 1084930 Positive_regulation CCND1 WNT2 24999833 2986687 Positive_regulation CCND1 WNT2 25386960 3024900 Positive_regulation CCND1 WNT2 25393427 3026802 Positive_regulation CCND1 WNT3 11739413 1277243 Positive_regulation CCND1 WNT3 18218096 281108 Positive_regulation CCND1 WNT3 20459685 1854904 Positive_regulation CCND1 WNT3 20802536 2135935 Positive_regulation CCND1 WNT3 21888663 174583 Positive_regulation CCND1 WNT3 22298956 1059690 Positive_regulation CCND1 WNT3 22889244 1506465 Positive_regulation CCND1 WNT3 23772418 945465 Positive_regulation CCND1 WNT3 23844215 2819610 Positive_regulation CCND1 WNT3 24256736 1700932 Positive_regulation CCND1 WNT3 24324366 1084931 Positive_regulation CCND1 WNT3 24999833 2986688 Positive_regulation CCND1 WNT3 25386960 3024901 Positive_regulation CCND1 WNT3 25393427 3026803 Positive_regulation CCND1 WNT3A 18452624 1646335 Positive_regulation CCND1 WNT3A 19304756 2042840 Positive_regulation CCND1 WNT3A 22491013 771642 Positive_regulation CCND1 WNT3A 22876125 1914712 Positive_regulation CCND1 WNT3A 24273411 2122479 Positive_regulation CCND1 WNT3A 24273411 2122483 Positive_regulation CCND1 WNT3A 24273411 2122486 Positive_regulation CCND1 WNT4 11739413 1277244 Positive_regulation CCND1 WNT4 18218096 281109 Positive_regulation CCND1 WNT4 20459685 1854905 Positive_regulation CCND1 WNT4 20802536 2135936 Positive_regulation CCND1 WNT4 21888663 174584 Positive_regulation CCND1 WNT4 22298956 1059691 Positive_regulation CCND1 WNT4 22889244 1506466 Positive_regulation CCND1 WNT4 23772418 945466 Positive_regulation CCND1 WNT4 23844215 2819611 Positive_regulation CCND1 WNT4 24256736 1700933 Positive_regulation CCND1 WNT4 24324366 1084932 Positive_regulation CCND1 WNT4 24999833 2986689 Positive_regulation CCND1 WNT4 25386960 3024902 Positive_regulation CCND1 WNT4 25393427 3026804 Positive_regulation CCND1 WNT6 11739413 1277245 Positive_regulation CCND1 WNT6 18218096 281110 Positive_regulation CCND1 WNT6 20459685 1854906 Positive_regulation CCND1 WNT6 20802536 2135937 Positive_regulation CCND1 WNT6 21888663 174585 Positive_regulation CCND1 WNT6 22298956 1059692 Positive_regulation CCND1 WNT6 22889244 1506467 Positive_regulation CCND1 WNT6 23772418 945467 Positive_regulation CCND1 WNT6 23844215 2819612 Positive_regulation CCND1 WNT6 24256736 1700934 Positive_regulation CCND1 WNT6 24324366 1084933 Positive_regulation CCND1 WNT6 24999833 2986690 Positive_regulation CCND1 WNT6 25386960 3024903 Positive_regulation CCND1 WNT6 25393427 3026805 Positive_regulation CCND1 XBP1 22022578 2563953 Positive_regulation CCND1 XBP1 22022578 2563954 Positive_regulation CCND1 XPO1 16503970 1845082 Positive_regulation CCND1 XPO1 16503970 1845093 Positive_regulation CCND1 XPO1 16503970 1845098 Positive_regulation CCND1 XPO1 16504004 1845123 Positive_regulation CCND1 XPO1 16504004 1845133 Positive_regulation CCND1 XPO1 16504004 1845194 Positive_regulation CCND1 XPO1 17224055 580982 Positive_regulation CCND1 XPO1 19669224 1619360 Positive_regulation CCND1 YAP1 24779718 1874231 Positive_regulation CCND1 YAP1 24779718 1874235 Positive_regulation CCND1 YBX1 23462806 440319 Positive_regulation CCND1 YBX1 23462806 440320 Positive_regulation CCND1 ZGLP1 24843404 1492966 Positive_regulation CCND1 ZNF703 19330026 2124990 Positive_regulation CCND1 ZNF703 21635707 467838 Positive_regulation CCND2 CCND1 17134502 359549 Positive_regulation CCND2 FOXO1 24416423 2908957 Positive_regulation CCND2 HBEGF 19337254 432031 Positive_regulation CCND2 HBEGF 19337254 432039 Positive_regulation CCND2 HBEGF 22646534 264700 Positive_regulation CCND3 CCND1 20113529 1853270 Positive_regulation CCNE1 CCND1 18927618 2398442 Positive_regulation CCNE1 CCND1 25047753 240809 Positive_regulation CCNE1 EPHB2 19665013 698141 Positive_regulation CCNE1 IFI27 22417103 587247 Positive_regulation CCNF IFI27 22158041 2144786 Positive_regulation CCNG1 CCND1 16504004 1845171 Positive_regulation CCNG1 CCND1 23552696 2156338 Positive_regulation CCNG1 CDKN1C 22216119 2584402 Positive_regulation CCNG1 CTGF 24152728 1819396 Positive_regulation CCNG1 EPHB2 21910869 3091308 Positive_regulation CCNG1 IFI27 20200561 1719461 Positive_regulation CCNG1 S100B 25536222 3035752 Positive_regulation CCNG2 FOXA1 24564526 240544 Positive_regulation CCNH TNF 21062494 313323 Positive_regulation CCNT1 EPHB2 23658523 3061142 Positive_regulation CCNT1 JAG1 19015152 2037570 Positive_regulation CCNT1 RNASE1 22379134 2073086 Positive_regulation CCNT1 STK39 22860019 2671092 Positive_regulation CCNT2 RNASE1 22379134 2073087 Positive_regulation CCR2 F2R 22992722 988785 Positive_regulation CCR2 FOXO1 22586579 722747 Positive_regulation CCR2 FOXO1 22586579 722766 Positive_regulation CCR2 FOXO1 22586579 722774 Positive_regulation CCR2 FOXO1 22586579 722775 Positive_regulation CCR2 TLR7 PMC4085409 661270 Positive_regulation CCR2 TNF 19736220 811449 Positive_regulation CCR2 TNF 23758766 3121891 Positive_regulation CCR2 TNF 24384839 1122808 Positive_regulation CCR4 CCL17 19715610 3109783 Positive_regulation CCR4 CCL17 25546419 3036556 Positive_regulation CCR4 TNF PMC3007769 1702458 Positive_regulation CCR5 MIP 23217137 3121041 Positive_regulation CCR5 TLR7 23028330 3059478 Positive_regulation CCR5 TNF 14514472 1738992 Positive_regulation CCR5 TNF 21508508 736867 Positive_regulation CCR6 TLR7 23554682 1225965 Positive_regulation CCR6 TNF 24699535 2948640 Positive_regulation CCR7 EPHB2 21698152 2530446 Positive_regulation CCR7 FOXO1 22654881 901222 Positive_regulation CCR7 TLR7 18461564 807255 Positive_regulation CCR7 TLR7 18461564 807316 Positive_regulation CCR7 TLR7 18461564 807317 Positive_regulation CCR7 TLR7 18461564 807428 Positive_regulation CCR7 TLR7 18461564 807518 Positive_regulation CCR7 TLR7 22427987 2610852 Positive_regulation CCR7 TLR7 24586760 2926339 Positive_regulation CCR7 TLR7 25093709 34229 Positive_regulation CCR7 TNF 12186834 1524516 Positive_regulation CCR7 TNF 22951718 1631199 Positive_regulation CCR7 TNF 25200712 1041216 Positive_regulation CCR9 TNF 25248373 133585 Positive_regulation CD14 APOB 20946675 1723265 Positive_regulation CD14 CA2 22719740 901954 Positive_regulation CD14 CA2 23898465 864148 Positive_regulation CD14 CAMP 19607716 325816 Positive_regulation CD14 CASP1 23190696 127495 Positive_regulation CD14 CASP1 23190696 127498 Positive_regulation CD14 CD1A 24846008 2972082 Positive_regulation CD14 CD209 12515819 1525696 Positive_regulation CD14 CD83 21235824 354275 Positive_regulation CD14 CD8A 17678538 351930 Positive_regulation CD14 CD8B 17678538 351931 Positive_regulation CD14 CEBPA 22879381 2080313 Positive_regulation CD14 CRX 23166489 3060014 Positive_regulation CD14 CSF1 24651442 573466 Positive_regulation CD14 CSF1R 22879381 2080320 Positive_regulation CD14 CSF2 11686890 3103519 Positive_regulation CD14 CSF2 1708813 1543157 Positive_regulation CD14 CSF2 22355289 956385 Positive_regulation CD14 CSF2 23234315 1665484 Positive_regulation CD14 CSF2 23234315 1665485 Positive_regulation CD14 CSF2 23234315 1665486 Positive_regulation CD14 CSF2 23234315 1665499 Positive_regulation CD14 CSF2 23234315 1665500 Positive_regulation CD14 CSF2 23234315 1665501 Positive_regulation CD14 CSF2 23234315 1665508 Positive_regulation CD14 CSF2 23234315 1665509 Positive_regulation CD14 CSF2 23234315 1665513 Positive_regulation CD14 CSF3 17254313 232997 Positive_regulation CD14 CSN1S1 24083466 356496 Positive_regulation CD14 CYP24A1 23497279 268036 Positive_regulation CD14 DUT 22566960 900539 Positive_regulation CD14 GAL 24353831 2115395 Positive_regulation CD14 HCLS1 22879381 2080319 Positive_regulation CD14 HMGB1 20706656 1747785 Positive_regulation CD14 HMGB1 24321251 660630 Positive_regulation CD14 HMOX1 24651442 573468 Positive_regulation CD14 IL10 21314968 3209856 Positive_regulation CD14 IL10 23734330 2162391 Positive_regulation CD14 IL10 23734330 2162395 Positive_regulation CD14 IL10 25025695 2989303 Positive_regulation CD14 IL11 25025695 2989304 Positive_regulation CD14 IL12A 23223197 3221945 Positive_regulation CD14 IL12B 23223197 3221946 Positive_regulation CD14 IL13 25025695 2989305 Positive_regulation CD14 IL15 25025695 2989306 Positive_regulation CD14 IL16 25025695 2989307 Positive_regulation CD14 IL17A 20167120 118358 Positive_regulation CD14 IL17A 20167120 118364 Positive_regulation CD14 IL18 25025695 2989308 Positive_regulation CD14 IL19 25025695 2989309 Positive_regulation CD14 IL1A 20144206 19874 Positive_regulation CD14 IL1A 20946675 1723310 Positive_regulation CD14 IL1A 21352551 1626335 Positive_regulation CD14 IL1A PMC3508816 1702679 Positive_regulation CD14 IL2 25025695 2989310 Positive_regulation CD14 IL2 8418199 1595140 Positive_regulation CD14 IL20 25025695 2989311 Positive_regulation CD14 IL21 25025695 2989312 Positive_regulation CD14 IL22 25025695 2989295 Positive_regulation CD14 IL24 25025695 2989292 Positive_regulation CD14 IL25 25025695 2989294 Positive_regulation CD14 IL26 25025695 2989299 Positive_regulation CD14 IL27 25025695 2989300 Positive_regulation CD14 IL3 25025695 2989313 Positive_regulation CD14 IL31 25025695 2989301 Positive_regulation CD14 IL32 23190696 127467 Positive_regulation CD14 IL32 25025695 2989298 Positive_regulation CD14 IL33 23236253 983728 Positive_regulation CD14 IL33 25025695 2989297 Positive_regulation CD14 IL34 25025695 2989302 Positive_regulation CD14 IL37 25025695 2989296 Positive_regulation CD14 IL4 11686890 3103520 Positive_regulation CD14 IL4 23103943 1931878 Positive_regulation CD14 IL4 25025695 2989314 Positive_regulation CD14 IL4 25250025 914195 Positive_regulation CD14 IL5 25025695 2989315 Positive_regulation CD14 IL6 10075974 1511206 Positive_regulation CD14 IL6 20946675 1723311 Positive_regulation CD14 IL6 22566960 900525 Positive_regulation CD14 IL6 23803652 1108018 Positive_regulation CD14 IL6 24489448 1757429 Positive_regulation CD14 IL6 25025695 2989316 Positive_regulation CD14 IL6 25238263 2201153 Positive_regulation CD14 IL7 25025695 2989317 Positive_regulation CD14 IL8 25025695 2989318 Positive_regulation CD14 IL9 25025695 2989319 Positive_regulation CD14 ITGAM 12515819 1525697 Positive_regulation CD14 KLF13 23236253 983727 Positive_regulation CD14 LBP 1380063 1528807 Positive_regulation CD14 LBP 14979920 458310 Positive_regulation CD14 LBP 1708813 1543168 Positive_regulation CD14 LBP 21526997 1626343 Positive_regulation CD14 LBP 21804904 2219136 Positive_regulation CD14 LBP 23024464 1750608 Positive_regulation CD14 LBP 24743550 3066759 Positive_regulation CD14 LBP 25349574 1147456 Positive_regulation CD14 LBP 7505800 1588823 Positive_regulation CD14 LEP 23762319 2802991 Positive_regulation CD14 LRRK2 21738687 2533265 Positive_regulation CD14 LY96 20419140 2447169 Positive_regulation CD14 LY96 20419140 2447173 Positive_regulation CD14 LY96 23055710 1071985 Positive_regulation CD14 LY96 24602493 295931 Positive_regulation CD14 LY96 24971030 1140229 Positive_regulation CD14 LY96 25332099 607551 Positive_regulation CD14 MLYCD 25609892 1763561 Positive_regulation CD14 MMP9 22174822 2582294 Positive_regulation CD14 MYD88 25332099 607552 Positive_regulation CD14 NOD1 21785567 1222356 Positive_regulation CD14 NOS2 9792334 1763750 Positive_regulation CD14 NPM1 21724521 794401 Positive_regulation CD14 PI3 10587349 1513463 Positive_regulation CD14 PI3 10587349 1513464 Positive_regulation CD14 PI3 10587349 1513472 Positive_regulation CD14 SAA1 17997851 1625037 Positive_regulation CD14 SEPT4 7505800 1588824 Positive_regulation CD14 SLC5A1 23936392 2830225 Positive_regulation CD14 SPI1 22879381 2080318 Positive_regulation CD14 TDGF1P3 12515819 1525695 Positive_regulation CD14 TLR1 25024136 1577062 Positive_regulation CD14 TLR10 25024136 1577070 Positive_regulation CD14 TLR2 20011115 3045868 Positive_regulation CD14 TLR2 21633096 1992267 Positive_regulation CD14 TLR2 22566960 900538 Positive_regulation CD14 TLR2 24302927 910053 Positive_regulation CD14 TLR2 24349012 2896585 Positive_regulation CD14 TLR2 25024136 1577063 Positive_regulation CD14 TLR2 25161655 913918 Positive_regulation CD14 TLR2 25474158 2373481 Positive_regulation CD14 TLR3 21078886 1561457 Positive_regulation CD14 TLR3 25024136 1577064 Positive_regulation CD14 TLR4 20419140 2447168 Positive_regulation CD14 TLR4 20419140 2447172 Positive_regulation CD14 TLR4 22442690 2612925 Positive_regulation CD14 TLR4 23049772 2699446 Positive_regulation CD14 TLR4 23055710 1071984 Positive_regulation CD14 TLR4 23990939 2840476 Positive_regulation CD14 TLR4 24602493 295930 Positive_regulation CD14 TLR4 24708794 1667962 Positive_regulation CD14 TLR4 25024136 1577065 Positive_regulation CD14 TLR4 25071777 913399 Positive_regulation CD14 TLR4 25332099 607550 Positive_regulation CD14 TLR4 25421042 1887454 Positive_regulation CD14 TLR5 25024136 1577066 Positive_regulation CD14 TLR6 25024136 1577071 Positive_regulation CD14 TLR6 25161655 913919 Positive_regulation CD14 TLR7 21078886 1561458 Positive_regulation CD14 TLR7 25024136 1577067 Positive_regulation CD14 TLR8 25024136 1577068 Positive_regulation CD14 TLR9 25024136 1577069 Positive_regulation CD14 TNF 14960189 656441 Positive_regulation CD14 TNF 20144206 19873 Positive_regulation CD14 TNF 20946675 1723334 Positive_regulation CD14 TNF 21352551 1626334 Positive_regulation CD14 TNF 24489448 1757436 Positive_regulation CD14 TNF 25025695 2989293 Positive_regulation CD14 TNF PMC3168235 807053 Positive_regulation CD14 TSLP 23190696 127371 Positive_regulation CD14 TSLP 23190696 127384 Positive_regulation CD14 TSLP 23190696 127468 Positive_regulation CD14 VCAN 20706656 1747784 Positive_regulation CD14 VDR 10587349 1513462 Positive_regulation CD163 TNF 23326413 2740080 Positive_regulation CD163 TNF 23326413 2740081 Positive_regulation CD163 TNF 23326413 2740082 Positive_regulation CD163 TNF 23781295 2226304 Positive_regulation CD19 CD22 21826145 1144685 Positive_regulation CD19 TLR7 24740301 2954618 Positive_regulation CD19 TLR7 24740301 2954619 Positive_regulation CD19 TNF 20617141 1215579 Positive_regulation CD19 TNF 20617141 1215581 Positive_regulation CD1A CD14 24846008 2972083 Positive_regulation CD1B ID1 24572994 1142515 Positive_regulation CD1D FAS 22837759 902656 Positive_regulation CD2 EPHB2 18629305 793221 Positive_regulation CD2 EPHB2 18629305 793381 Positive_regulation CD207 TNF 12186835 1524520 Positive_regulation CD207 TNF 12186835 1524542 Positive_regulation CD207 TNF 12186835 1524544 Positive_regulation CD207 TNF 21410677 450514 Positive_regulation CD209 EPHB2 18282094 3040988 Positive_regulation CD209 TLR7 16279841 2368545 Positive_regulation CD209 TLR7 22427987 2610862 Positive_regulation CD209 TLR7 23762096 637776 Positive_regulation CD22 BCR 24344237 1574231 Positive_regulation CD22 BCR 8627166 1596117 Positive_regulation CD22 CD19 19707370 175625 Positive_regulation CD22 CXCL9 11994425 1523383 Positive_regulation CD22 IL4 1985119 1556570 Positive_regulation CD22 LYN 9547345 1602691 Positive_regulation CD22 PTPN6 8627166 1596133 Positive_regulation CD22 TLR3 22566885 899543 Positive_regulation CD22 TLR4 22566885 899544 Positive_regulation CD22 TLR9 22566885 899545 Positive_regulation CD22 TNF 1985119 1556569 Positive_regulation CD226 ITGAL 12913096 1528201 Positive_regulation CD226 ITGAL 22238634 2586746 Positive_regulation CD226 ITGB2 14676297 1529999 Positive_regulation CD226 ITGB2 14676297 1530006 Positive_regulation CD24 NR2F1 23785296 2346927 Positive_regulation CD24 PLAU 23864708 1817022 Positive_regulation CD24 S100A7 23300877 2736921 Positive_regulation CD24 S100A7 23300877 2736954 Positive_regulation CD24 TFPI2 PMC2756345 496058 Positive_regulation CD248 TNF 24555435 271761 Positive_regulation CD27 FAS 22837759 902648 Positive_regulation CD27 PECAM1 23054369 1654675 Positive_regulation CD274 EPHB2 23737812 637500 Positive_regulation CD274 EPHB2 24945934 2981748 Positive_regulation CD274 MAP2K6 20814675 488029 Positive_regulation CD274 MAP2K6 20814675 488064 Positive_regulation CD274 MAP2K6 23737812 637507 Positive_regulation CD274 TLR7 19294011 2214869 Positive_regulation CD274 TLR7 20814675 488083 Positive_regulation CD274 TLR7 22930672 3131223 Positive_regulation CD274 TLR7 24624132 911878 Positive_regulation CD274 TLR7 24739950 2953688 Positive_regulation CD274 TLR7 25093709 34249 Positive_regulation CD274 TNF 11094427 98124 Positive_regulation CD274 TNF 19451266 1554820 Positive_regulation CD274 TNF 19451266 1554821 Positive_regulation CD274 TNF 20814675 488022 Positive_regulation CD274 TNF 22067141 1660212 Positive_regulation CD274 TNF 22389764 3130458 Positive_regulation CD274 TNF 22389764 3130460 Positive_regulation CD274 TNF 22389764 3130461 Positive_regulation CD274 TNF 22389764 3130462 Positive_regulation CD274 TNF 22389764 3130463 Positive_regulation CD274 TNF 22389764 3130466 Positive_regulation CD274 TNF 22389764 3130467 Positive_regulation CD274 TNF 22389764 3130468 Positive_regulation CD274 TNF 22389764 3130474 Positive_regulation CD274 TNF 23533994 180666 Positive_regulation CD274 TNF 23882269 908245 Positive_regulation CD274 TNF 25125485 505186 Positive_regulation CD276 TLR7 12045249 1523601 Positive_regulation CD276 TLR7 22427987 2610872 Positive_regulation CD276 TLR7 22815909 2666713 Positive_regulation CD276 TLR7 24223593 1070221 Positive_regulation CD28 EPHB2 15833106 3104971 Positive_regulation CD28 EPHB2 24330710 538567 Positive_regulation CD28 EPHB2 24465689 2911417 Positive_regulation CD28 FAS 9815257 1604655 Positive_regulation CD28 HES2 20876311 1560378 Positive_regulation CD28 ITGAL 1569401 1534406 Positive_regulation CD28 ITGB2 9653089 1603140 Positive_regulation CD28 STAT4 24842371 1576364 Positive_regulation CD28 TNF 23077634 2705066 Positive_regulation CD28 TNFSF10 22412938 2609855 Positive_regulation CD28 TNFSF10 22412938 2609859 Positive_regulation CD33 TNF 22500980 355794 Positive_regulation CD34 CD14 21209798 1084119 Positive_regulation CD34 PECAM1 25051267 2287473 Positive_regulation CD34 TNF 7525840 1589670 Positive_regulation CD36 EPHB2 19343212 3043670 Positive_regulation CD36 FAS 15869703 2112236 Positive_regulation CD36 FOXO1 23130316 730561 Positive_regulation CD36 FOXO1 25045276 645410 Positive_regulation CD36 PGC 22272266 2589501 Positive_regulation CD36 RCAN1 24127415 783281 Positive_regulation CD36 RCAN1 24127415 783282 Positive_regulation CD36 TLR7 21949655 3053552 Positive_regulation CD36 TNF 21029292 590589 Positive_regulation CD36 TNF 21855683 83495 Positive_regulation CD36 TNF 22007304 1145367 Positive_regulation CD36 TNF 22349260 600637 Positive_regulation CD36 TNFSF10 24466325 2914329 Positive_regulation CD38 PECAM1 22720208 2160923 Positive_regulation CD38 TNF 18341691 3108818 Positive_regulation CD38 TNF 18341691 3108819 Positive_regulation CD38 TNF 18341691 3108820 Positive_regulation CD38 TNF 18341691 3108822 Positive_regulation CD38 TNF 18341691 3108823 Positive_regulation CD38 TNF 18341691 3108841 Positive_regulation CD38 TNF 18341691 3108856 Positive_regulation CD38 TNF 18341691 3108858 Positive_regulation CD38 TNF 23213344 1156366 Positive_regulation CD38 TNF 23213344 1156369 Positive_regulation CD38 TNF 23213344 1156370 Positive_regulation CD38 TNF 23213344 1156371 Positive_regulation CD38 TNF 25175907 3114884 Positive_regulation CD38 TNF 8627186 1596301 Positive_regulation CD3D EPHB2 9396757 1465231 Positive_regulation CD3D ITGB2 15477347 1533592 Positive_regulation CD3E EPHB2 9396757 1465232 Positive_regulation CD3E IL1B 20498845 2451117 Positive_regulation CD3E ITGB2 15477347 1533593 Positive_regulation CD3G EPHB2 9396757 1465233 Positive_regulation CD3G ITGB2 15477347 1533594 Positive_regulation CD4 CCND1 19707583 2424543 Positive_regulation CD4 CCND1 23151022 266838 Positive_regulation CD4 CD14 23226194 2723528 Positive_regulation CD4 EPHB2 23742646 3121853 Positive_regulation CD4 FAS 23021024 3215123 Positive_regulation CD4 FAS 23762329 2803027 Positive_regulation CD4 FAS 9334376 1601782 Positive_regulation CD4 ITGAL 25414732 641074 Positive_regulation CD4 ITGAL 25414732 641077 Positive_regulation CD4 JAG1 11581320 1521131 Positive_regulation CD4 JAG1 25317714 1764750 Positive_regulation CD4 MIP 7595201 1590756 Positive_regulation CD4 NT5E 23125523 1225571 Positive_regulation CD4 SELL 20126660 2439975 Positive_regulation CD4 SELL 7525854 1589722 Positive_regulation CD4 STAT4 10209051 1511650 Positive_regulation CD4 TCN1 22750193 1492594 Positive_regulation CD4 TLR7 20533427 774778 Positive_regulation CD4 TLR7 21251257 354290 Positive_regulation CD4 TLR7 21251257 354310 Positive_regulation CD4 TLR7 21912648 2552501 Positive_regulation CD4 TLR7 21998589 3053958 Positive_regulation CD4 TLR7 22206014 2584255 Positive_regulation CD4 TLR7 23028330 3059488 Positive_regulation CD4 TLR7 23935491 3063320 Positive_regulation CD4 TLR7 24133492 909233 Positive_regulation CD4 TMEM100 19478868 3043946 Positive_regulation CD4 TMEM156 19478868 3043964 Positive_regulation CD4 TMEM211 19478868 3044044 Positive_regulation CD4 TMEM213 19478868 3043981 Positive_regulation CD4 TNF 24795723 912563 Positive_regulation CD4 TNF 25500571 2373510 Positive_regulation CD4 TNF PMC3920362 3102777 Positive_regulation CD40 CHI3L1 7688786 1591573 Positive_regulation CD40 CHI3L1 9814595 702689 Positive_regulation CD40 EPHB2 19399172 2415458 Positive_regulation CD40 EPHB2 20100871 1557335 Positive_regulation CD40 EPHB2 21599982 527493 Positive_regulation CD40 EPHB2 25255446 2372971 Positive_regulation CD40 F2R 22096359 1628308 Positive_regulation CD40 FAS 16545138 249262 Positive_regulation CD40 FAS 17562816 1546356 Positive_regulation CD40 FAS 7595197 1590744 Positive_regulation CD40 FAS 8551247 1595974 Positive_regulation CD40 FAS 8551247 1595975 Positive_regulation CD40 FAS 8642300 1596780 Positive_regulation CD40 FAS 8691124 1598040 Positive_regulation CD40 FAS 9064343 1600341 Positive_regulation CD40 FAS 9064343 1600354 Positive_regulation CD40 FAS 9221764 1601329 Positive_regulation CD40 FAS 9683298 447463 Positive_regulation CD40 FAS 9683298 447464 Positive_regulation CD40 FAS 9683298 447465 Positive_regulation CD40 ITGAL 9314566 1601696 Positive_regulation CD40 ITGB2 23785403 2805730 Positive_regulation CD40 JAG1 22829976 218100 Positive_regulation CD40 MAP2K6 24194739 909649 Positive_regulation CD40 TLR7 18652679 352338 Positive_regulation CD40 TLR7 21494377 1037989 Positive_regulation CD40 TLR7 21773041 1496885 Positive_regulation CD40 TLR7 22125457 3152240 Positive_regulation CD40 TLR7 22193989 488195 Positive_regulation CD40 TLR7 22571761 125851 Positive_regulation CD40 TLR7 24523723 911005 Positive_regulation CD40 TLR7 24842926 1049980 Positive_regulation CD40 TNF 10075983 1511259 Positive_regulation CD40 TNF 10839815 1515751 Positive_regulation CD40 TNF 12823847 99840 Positive_regulation CD40 TNF 16104828 2368419 Positive_regulation CD40 TNF 17893200 1547185 Positive_regulation CD40 TNF 20100871 1557334 Positive_regulation CD40 TNF 20429874 1656232 Positive_regulation CD40 TNF 21286280 667795 Positive_regulation CD40 TNF 22110533 633563 Positive_regulation CD40 TNF 22547990 3152587 Positive_regulation CD40 TNF 22547990 3152592 Positive_regulation CD40 TNF 22547990 3152604 Positive_regulation CD40 TNF 22547990 3152608 Positive_regulation CD40 TNF 22547990 3152629 Positive_regulation CD40 TNF 23533792 1151618 Positive_regulation CD40 TNF 24341851 346168 Positive_regulation CD40 TNF 25375372 578822 Positive_regulation CD40 TNF PMC2833524 134183 Positive_regulation CD40 TNF PMC2833524 134187 Positive_regulation CD40 TNFSF10 24232092 569066 Positive_regulation CD40LG F2R 22096359 1628309 Positive_regulation CD40LG FAS 10075978 1511219 Positive_regulation CD40LG FAS 17562816 1546359 Positive_regulation CD40LG FAS PMC2062908 448327 Positive_regulation CD40LG TNF 20429874 1656233 Positive_regulation CD40LG TNF 20808842 2472751 Positive_regulation CD40LG TNF 21689404 3119735 Positive_regulation CD40LG TNF 23986761 908675 Positive_regulation CD40LG TNF 9841916 1604729 Positive_regulation CD44 EPHB2 23304519 1496999 Positive_regulation CD44 EPHB2 24180670 270277 Positive_regulation CD44 EPHB2 24180670 270279 Positive_regulation CD44 FAS 8769429 1455895 Positive_regulation CD44 HBEGF 17177600 2368918 Positive_regulation CD44 ID1 24572994 1142516 Positive_regulation CD44 ITGAL 7520473 1589470 Positive_regulation CD44 ITGB2 23750158 907366 Positive_regulation CD44 ITGB2 24376813 2902251 Positive_regulation CD44 MAP2K6 18793421 251507 Positive_regulation CD44 MMP28 21179550 2489068 Positive_regulation CD44 MMP7 21179550 2489105 Positive_regulation CD44 PECAM1 24312447 2889509 Positive_regulation CD44 PLAU 22621373 471547 Positive_regulation CD44 SELL 18391078 217645 Positive_regulation CD44 TNF 16831885 1331036 Positive_regulation CD44 TNF 19132087 2307207 Positive_regulation CD44 TNF 23762326 2803023 Positive_regulation CD44 TNF 23762326 2803024 Positive_regulation CD44 TNF 24809021 947827 Positive_regulation CD44 TNF 7507492 1435169 Positive_regulation CD46 F2R 18606855 1551550 Positive_regulation CD46 MMP28 23144765 2714563 Positive_regulation CD46 MMP7 23144765 2714578 Positive_regulation CD46 TNF 21845215 1669468 Positive_regulation CD47 TNF 21855683 83496 Positive_regulation CD47 TNF PMC2750202 450200 Positive_regulation CD5 FAS 22837759 902661 Positive_regulation CD53 ITGAL 24832104 2970521 Positive_regulation CD53 ITGB2 24832104 2970517 Positive_regulation CD55 CD14 23152895 2716577 Positive_regulation CD55 FOXO1 19749979 2310918 Positive_regulation CD55 FOXO1 20824162 2272318 Positive_regulation CD55 FOXO1 20975207 28360 Positive_regulation CD55 FOXO1 21909281 2326124 Positive_regulation CD55 FOXO1 23049887 2699772 Positive_regulation CD55 FOXO1 23284299 2340783 Positive_regulation CD55 FOXO1 24385923 2354742 Positive_regulation CD55 TNF 19225537 1719187 Positive_regulation CD55 TNF 24880953 1644593 Positive_regulation CD58 TLR7 18652679 352342 Positive_regulation CD59 TLR7 23584892 780388 Positive_regulation CD59 TNF 19225537 1719186 Positive_regulation CD6 CA12 24861853 804379 Positive_regulation CD63 ARSA 22187572 1155941 Positive_regulation CD63 ARSA 22187572 1155942 Positive_regulation CD63 F2R 20177584 1046996 Positive_regulation CD69 EPHB2 23758320 151516 Positive_regulation CD69 EPHB2 24201811 568992 Positive_regulation CD69 EPHB2 PMC2833665 134284 Positive_regulation CD69 ITGB2 18957484 90858 Positive_regulation CD69 TLR7 18382686 2387504 Positive_regulation CD69 TLR7 23448601 535765 Positive_regulation CD69 TNF 15743471 102499 Positive_regulation CD69 TNF 20508866 1910729 Positive_regulation CD69 TNF 23924945 1109771 Positive_regulation CD69 TNF PMC3273158 99555 Positive_regulation CD69 TNF PMC3300928 660908 Positive_regulation CD70 TLR7 22851815 1750146 Positive_regulation CD79A ALOX5 19503090 1948714 Positive_regulation CD79A CD22 10209047 1511612 Positive_regulation CD79A CD22 20098688 2437865 Positive_regulation CD79A CD22 20098688 2437877 Positive_regulation CD79A CD22 22566885 899288 Positive_regulation CD79A PECAM1 23233201 1141367 Positive_regulation CD79A PIGR 10510081 1512422 Positive_regulation CD79A PIGR 18955273 811111 Positive_regulation CD79A PIGR 21451502 1918228 Positive_regulation CD79A PIGR 23284753 2730932 Positive_regulation CD79A PIGR 23579770 1491612 Positive_regulation CD79A PIGR 25437806 2234104 Positive_regulation CD79A SRGN 19958557 365716 Positive_regulation CD79A TCN1 21326197 1918178 Positive_regulation CD79A TF 11514599 1520539 Positive_regulation CD79A TGM2 21310073 229322 Positive_regulation CD79A TGM2 24130874 2867436 Positive_regulation CD79A TLR7 23049531 904454 Positive_regulation CD79A TLR7 23690823 637319 Positive_regulation CD79A TLR7 24562309 1959941 Positive_regulation CD79A TNF 18475715 1745519 Positive_regulation CD79A TNF 19210794 365554 Positive_regulation CD79A TNF 21781305 247864 Positive_regulation CD79B ALOX5 19503090 1948715 Positive_regulation CD79B CD22 10209047 1511613 Positive_regulation CD79B CD22 20098688 2437866 Positive_regulation CD79B CD22 20098688 2437878 Positive_regulation CD79B CD22 22566885 899301 Positive_regulation CD79B PECAM1 23233201 1141368 Positive_regulation CD79B TGM2 21310073 229329 Positive_regulation CD80 CHI3L1 7500044 1588513 Positive_regulation CD80 TLR7 18509450 2389638 Positive_regulation CD80 TLR7 18652679 352343 Positive_regulation CD80 TLR7 19750096 793756 Positive_regulation CD80 TLR7 20379390 1214449 Positive_regulation CD80 TLR7 21494377 1038009 Positive_regulation CD80 TLR7 21587207 769673 Positive_regulation CD80 TLR7 24952610 1702181 Positive_regulation CD80 TLR7 25295753 3012736 Positive_regulation CD80 TNF 17893200 1547186 Positive_regulation CD80 TNF 22951585 1035630 Positive_regulation CD81 ITGAL 12597781 350431 Positive_regulation CD81 TNF 24259385 1029581 Positive_regulation CD83 MAP2K6 24194739 909656 Positive_regulation CD83 TLR7 21220452 1562371 Positive_regulation CD83 TLR7 23071254 1569627 Positive_regulation CD83 TLR7 25093709 34239 Positive_regulation CD83 TNF 21689404 3119742 Positive_regulation CD83 TNF 23071254 1569626 Positive_regulation CD83 TNF 25111504 2996284 Positive_regulation CD86 CHI3L1 7595208 1590805 Positive_regulation CD86 CHI3L1 7595208 1590809 Positive_regulation CD86 MAP2K6 21054882 2231183 Positive_regulation CD86 TLR7 19734906 1953134 Positive_regulation CD86 TLR7 19750096 793766 Positive_regulation CD86 TLR7 20379390 1214463 Positive_regulation CD86 TLR7 21220452 1562385 Positive_regulation CD86 TLR7 21494377 1038019 Positive_regulation CD86 TLR7 21773041 1496895 Positive_regulation CD86 TLR7 21912648 2552513 Positive_regulation CD86 TLR7 23071254 1569643 Positive_regulation CD86 TLR7 23936008 2828972 Positive_regulation CD86 TLR7 24523723 911015 Positive_regulation CD86 TLR7 24586760 2926319 Positive_regulation CD86 TLR7 24842926 1050010 Positive_regulation CD86 TNF 12186835 1524517 Positive_regulation CD86 TNF 17893200 1547187 Positive_regulation CD86 TNF 22951585 1035637 Positive_regulation CD86 TNF 23071254 1569642 Positive_regulation CD8A EPHB2 20967853 135160 Positive_regulation CD8A FAS 19011158 1051110 Positive_regulation CD8A FAS 21935389 2555574 Positive_regulation CD8A FAS 23021024 3215124 Positive_regulation CD8A FAS 24949464 192748 Positive_regulation CD8A FAS 8642317 1596893 Positive_regulation CD8A JAG1 25317714 1764751 Positive_regulation CD8A SERPINA5 23977133 2838475 Positive_regulation CD8A STAT4 23939393 728369 Positive_regulation CD8A STAT4 25336459 1733392 Positive_regulation CD8A TCN1 25560237 3037215 Positive_regulation CD8A TLR7 21494377 1038029 Positive_regulation CD8A TLR7 21998589 3053952 Positive_regulation CD8A TLR7 23935491 3063321 Positive_regulation CD8A TNF 10637268 1514133 Positive_regulation CD8A TNF 11293812 702201 Positive_regulation CD8A TNF 17616976 3039684 Positive_regulation CD8A TNF 18431484 2387646 Positive_regulation CD8A TNF 23874808 2822895 Positive_regulation CD8A TNF 24475103 2914823 Positive_regulation CD8A TNF 24527245 515482 Positive_regulation CD8B EPHB2 20967853 135162 Positive_regulation CD8B FAS 21935389 2555575 Positive_regulation CD8B FAS 23021024 3215125 Positive_regulation CD8B STAT4 23939393 728370 Positive_regulation CD8B TCN1 25560237 3037216 Positive_regulation CD8B TLR7 21494377 1038039 Positive_regulation CD8B TLR7 21998589 3053953 Positive_regulation CD8B TLR7 23935491 3063322 Positive_regulation CD8B TNF 10637268 1514134 Positive_regulation CD8B TNF 11293812 702205 Positive_regulation CD8B TNF 17616976 3039685 Positive_regulation CD8B TNF 18431484 2387647 Positive_regulation CD8B TNF 24475103 2914826 Positive_regulation CD8B TNF 24527245 515485 Positive_regulation CD9 EPHB2 23284657 2730392 Positive_regulation CD9 LRRN2 19602272 1994803 Positive_regulation CD9 MAP2K6 25200404 3145505 Positive_regulation CD99 EPHB2 24677094 1238085 Positive_regulation CDC123 CFI 20660629 1377840 Positive_regulation CDC123 CFI 21536748 1386620 Positive_regulation CDC123 GPR132 21966461 2558964 Positive_regulation CDC123 GPR132 21966461 2558992 Positive_regulation CDC123 SLC6A2 22383977 2602795 Positive_regulation CDC123 TNFSF10 22355661 3130226 Positive_regulation CDC123 TNFSF10 22355661 3130227 Positive_regulation CDC123 TNFSF10 22355661 3130229 Positive_regulation CDC123 TNFSF10 25601862 921723 Positive_regulation CDC123 TNFSF10 25601862 921724 Positive_regulation CDC123 TNFSF10 25601862 921725 Positive_regulation CDC123 TNFSF10 25601862 921726 Positive_regulation CDC123 TNFSF10 25601862 921740 Positive_regulation CDC16 CFI 20660629 1377842 Positive_regulation CDC16 CFI 21536748 1386622 Positive_regulation CDC16 GPR132 21966461 2558965 Positive_regulation CDC16 GPR132 21966461 2558993 Positive_regulation CDC16 SLC6A2 22383977 2602797 Positive_regulation CDC20 CFI 20660629 1377844 Positive_regulation CDC20 CFI 21536748 1386624 Positive_regulation CDC20 GPR132 21966461 2558966 Positive_regulation CDC20 GPR132 21966461 2558994 Positive_regulation CDC20 SLC6A2 22383977 2602799 Positive_regulation CDC23 CFI 20660629 1377846 Positive_regulation CDC23 CFI 21536748 1386626 Positive_regulation CDC23 GPR132 21966461 2558967 Positive_regulation CDC23 GPR132 21966461 2558995 Positive_regulation CDC23 SLC6A2 22383977 2602801 Positive_regulation CDC25B NES 25059436 308266 Positive_regulation CDC25C EPHB2 22238511 2295387 Positive_regulation CDC25C EPHB2 24023871 2843840 Positive_regulation CDC25C EPHB2 24023871 2843864 Positive_regulation CDC26 CFI 20660629 1377864 Positive_regulation CDC26 CFI 21536748 1386644 Positive_regulation CDC26 GPR132 21966461 2558990 Positive_regulation CDC26 GPR132 21966461 2559004 Positive_regulation CDC26 SLC6A2 22383977 2602819 Positive_regulation CDC27 CFI 20660629 1377848 Positive_regulation CDC27 CFI 21536748 1386628 Positive_regulation CDC27 GPR132 21966461 2558968 Positive_regulation CDC27 GPR132 21966461 2558996 Positive_regulation CDC27 SLC6A2 22383977 2602803 Positive_regulation CDC34 CFI 20660629 1377850 Positive_regulation CDC34 CFI 21536748 1386630 Positive_regulation CDC34 GPR132 21966461 2558969 Positive_regulation CDC34 GPR132 21966461 2558997 Positive_regulation CDC34 SLC6A2 22383977 2602805 Positive_regulation CDC37 CFI 20660629 1377852 Positive_regulation CDC37 CFI 21536748 1386632 Positive_regulation CDC37 GPR132 21966461 2558970 Positive_regulation CDC37 GPR132 21966461 2558998 Positive_regulation CDC37 SLC6A2 22383977 2602807 Positive_regulation CDC40 CFI 20660629 1377854 Positive_regulation CDC40 CFI 21536748 1386634 Positive_regulation CDC40 GPR132 21966461 2558971 Positive_regulation CDC40 GPR132 21966461 2558999 Positive_regulation CDC40 SLC6A2 22383977 2602809 Positive_regulation CDC42 ABCA12 23829168 269320 Positive_regulation CDC42 ABCA4 23829168 269326 Positive_regulation CDC42 CFI 20660629 1377856 Positive_regulation CDC42 CFI 21536748 1386636 Positive_regulation CDC42 CTGF 23902294 344720 Positive_regulation CDC42 EPHB2 19182796 1965177 Positive_regulation CDC42 EPHB2 19182796 1965183 Positive_regulation CDC42 EPHB2 24632816 2934274 Positive_regulation CDC42 FZD4 23593172 2780052 Positive_regulation CDC42 GPR132 21966461 2558972 Positive_regulation CDC42 GPR132 21966461 2559000 Positive_regulation CDC42 ITGB2 21206905 2491149 Positive_regulation CDC42 PLAU 12952933 1296523 Positive_regulation CDC42 PLAU 12952933 1296552 Positive_regulation CDC42 PLAU 20067638 255169 Positive_regulation CDC42 SLC6A2 22383977 2602811 Positive_regulation CDC42 TLR7 21098092 1561625 Positive_regulation CDC45 CFI 20660629 1377858 Positive_regulation CDC45 CFI 21536748 1386638 Positive_regulation CDC45 GPR132 21966461 2558973 Positive_regulation CDC45 GPR132 21966461 2559001 Positive_regulation CDC45 SLC6A2 22383977 2602813 Positive_regulation CDC6 CFI 20660629 1377860 Positive_regulation CDC6 CFI 21536748 1386640 Positive_regulation CDC6 GPR132 21966461 2558974 Positive_regulation CDC6 GPR132 21966461 2559002 Positive_regulation CDC6 SLC6A2 22383977 2602815 Positive_regulation CDC7 CFI 20660629 1377862 Positive_regulation CDC7 CFI 21536748 1386642 Positive_regulation CDC7 GPR132 21966461 2558975 Positive_regulation CDC7 GPR132 21966461 2559003 Positive_regulation CDC7 SLC6A2 22383977 2602817 Positive_regulation CDC73 ALOX5 8666909 1597091 Positive_regulation CDC73 CFI 20660629 1377838 Positive_regulation CDC73 CFI 21536748 1386618 Positive_regulation CDC73 F2R PMC2756345 496001 Positive_regulation CDC73 GPR115 21079759 3049471 Positive_regulation CDC73 GPR115 25375862 3023394 Positive_regulation CDC73 GPR132 21079759 3049460 Positive_regulation CDC73 GPR132 21966461 2558963 Positive_regulation CDC73 GPR132 21966461 2558991 Positive_regulation CDC73 GPR132 25375862 3023383 Positive_regulation CDC73 GPR87 21079759 3049540 Positive_regulation CDC73 GPR87 25375862 3023463 Positive_regulation CDC73 LPCAT1 21079759 3049444 Positive_regulation CDC73 LPCAT1 25415055 177544 Positive_regulation CDC73 SLC6A2 22383977 2602793 Positive_regulation CDC73 TNF 18475680 1745375 Positive_regulation CDC73 TNF 18475682 1745388 Positive_regulation CDC73 TNF 18475742 1746297 Positive_regulation CDC73 TNF 21082032 2482397 Positive_regulation CDC73 TNF 2137857 1562735 Positive_regulation CDC73 TNF 2137857 1562745 Positive_regulation CDC73 TNF 21860543 1749380 Positive_regulation CDC73 TNF 2659725 1577674 Positive_regulation CDC73 TNF 3049910 1579705 Positive_regulation CDC73 TNF 3049910 1579706 Positive_regulation CDC73 TNF 3049910 1579707 Positive_regulation CDC73 TNF 3049910 1579708 Positive_regulation CDC73 TNF 3049910 1579770 Positive_regulation CDC73 TNF 3049910 1579786 Positive_regulation CDC73 TNF 3049910 1579796 Positive_regulation CDC73 TNF 3049910 1579801 Positive_regulation CDC73 TNF 3119758 1580103 Positive_regulation CDC73 TNF 3119758 1580104 Positive_regulation CDC73 TNF 3119758 1580105 Positive_regulation CDC73 TNF 3119758 1580106 Positive_regulation CDC73 TNF 3119758 1580107 Positive_regulation CDC73 TNF 3119758 1580168 Positive_regulation CDC73 TNF 7516414 1589274 Positive_regulation CDC73 TNF 7516414 1589279 Positive_regulation CDC73 TNF 7516414 1589299 Positive_regulation CDC73 TNF 7516414 1589304 Positive_regulation CDCA5 CAPN8 20200223 1774904 Positive_regulation CDCA5 NES 21278733 1966530 Positive_regulation CDCA5 NES 21278733 1966539 Positive_regulation CDCA5 TLR7 15851485 1535931 Positive_regulation CDCA5 TNF 23700396 1039652 Positive_regulation CDCA5 TNF 24498195 2918917 Positive_regulation CDH1 ARSA 23146664 154199 Positive_regulation CDH1 ARSA 23146664 154201 Positive_regulation CDH1 ARSA 24184502 154209 Positive_regulation CDH1 ARSA 24184502 154210 Positive_regulation CDH1 ARSA 24184502 154218 Positive_regulation CDH1 ARSA 24184502 154229 Positive_regulation CDH1 ARSA 24184502 154240 Positive_regulation CDH1 ARSA 24184502 154242 Positive_regulation CDH1 AXIN2 25149539 2198495 Positive_regulation CDH1 CLDN10 21619599 3112205 Positive_regulation CDH1 CLU 22949882 1098128 Positive_regulation CDH1 CTGF 20393144 713771 Positive_regulation CDH1 CTGF 20393144 713776 Positive_regulation CDH1 CTGF 23750089 163593 Positive_regulation CDH1 CTGF 24550986 1074013 Positive_regulation CDH1 CTGF 24919189 2979603 Positive_regulation CDH1 EPHB2 14623871 1301342 Positive_regulation CDH1 EPHB2 14623871 1301343 Positive_regulation CDH1 EPHB2 24130883 2867461 Positive_regulation CDH1 EPHB2 24168056 1700769 Positive_regulation CDH1 FOXA1 22590586 2642261 Positive_regulation CDH1 FOXA1 22590586 2642263 Positive_regulation CDH1 FOXA1 22590586 2642264 Positive_regulation CDH1 GJB2 9722615 1470564 Positive_regulation CDH1 ID1 23320068 2739494 Positive_regulation CDH1 ID1 24137437 2165747 Positive_regulation CDH1 ID1 24137437 2165754 Positive_regulation CDH1 ID1 24347544 752266 Positive_regulation CDH1 MAP2K6 16365168 1326392 Positive_regulation CDH1 MAP2K6 23208503 2150362 Positive_regulation CDH1 MAP2K6 24708867 272683 Positive_regulation CDH1 MMP28 15668718 425243 Positive_regulation CDH1 MMP28 22593767 1673880 Positive_regulation CDH1 MMP7 15668718 425258 Positive_regulation CDH1 MMP7 21274443 1673079 Positive_regulation CDH1 MMP7 22593767 1673898 Positive_regulation CDH1 MMP7 22902510 834888 Positive_regulation CDH1 MMP7 23173031 2719400 Positive_regulation CDH1 MMP7 23698793 3136049 Positive_regulation CDH1 MSX1 21433221 3171214 Positive_regulation CDH1 NEDD9 21765937 2536541 Positive_regulation CDH1 NEDD9 24058594 2848131 Positive_regulation CDH1 NEDD9 24058594 2848152 Positive_regulation CDH1 PLAU 22593767 1673902 Positive_regulation CDH1 TNF 21410677 450512 Positive_regulation CDH1 VSNL1 22479362 2614951 Positive_regulation CDH1 WIF1 20573255 1856521 Positive_regulation CDH1 WIF1 20573255 1856527 Positive_regulation CDH1 WNT7A 22313908 263419 Positive_regulation CDH1 WNT7A 23284647 2730366 Positive_regulation CDH1 WNT7A 24204697 2873493 Positive_regulation CDH10 AXIN2 25149539 2198499 Positive_regulation CDH10 MAP2K6 23208503 2150372 Positive_regulation CDH10 MSX1 21433221 3171217 Positive_regulation CDH11 AXIN2 25149539 2198503 Positive_regulation CDH11 MAP2K6 23208503 2150382 Positive_regulation CDH11 MSX1 21433221 3171220 Positive_regulation CDH12 AXIN2 25149539 2198507 Positive_regulation CDH12 MAP2K6 23208503 2150392 Positive_regulation CDH12 MSX1 21433221 3171223 Positive_regulation CDH13 AXIN2 25149539 2198511 Positive_regulation CDH13 MAP2K6 23208503 2150402 Positive_regulation CDH13 MSX1 21433221 3171226 Positive_regulation CDH13 TNF 19159481 1655612 Positive_regulation CDH13 TNF 24580841 3169893 Positive_regulation CDH15 AXIN2 25149539 2198515 Positive_regulation CDH15 MAP2K6 23208503 2150412 Positive_regulation CDH15 MSX1 21433221 3171229 Positive_regulation CDH16 AXIN2 25149539 2198519 Positive_regulation CDH16 MAP2K6 23208503 2150422 Positive_regulation CDH16 MSX1 21433221 3171232 Positive_regulation CDH17 AXIN2 25149539 2198523 Positive_regulation CDH17 MAP2K6 23208503 2150432 Positive_regulation CDH17 MSX1 21433221 3171235 Positive_regulation CDH18 AXIN2 25149539 2198527 Positive_regulation CDH18 MAP2K6 23208503 2150442 Positive_regulation CDH18 MSX1 21433221 3171238 Positive_regulation CDH19 AXIN2 25149539 2198531 Positive_regulation CDH19 MAP2K6 23208503 2150452 Positive_regulation CDH19 MSX1 21433221 3171241 Positive_regulation CDH2 ANGPT1 21378411 2175496 Positive_regulation CDH2 ANGPT1 22190963 3172956 Positive_regulation CDH2 AXIN2 25149539 2198535 Positive_regulation CDH2 EPHB2 24465772 2911751 Positive_regulation CDH2 MAP2K6 23208503 2150462 Positive_regulation CDH2 MMP28 20139113 513520 Positive_regulation CDH2 MMP7 20139113 513535 Positive_regulation CDH2 MMP7 20139113 513580 Positive_regulation CDH2 MMP7 20139113 513626 Positive_regulation CDH2 MMP7 24400123 2905908 Positive_regulation CDH2 MSX1 21433221 3171244 Positive_regulation CDH2 PCDH19 22184198 1394561 Positive_regulation CDH2 TNF 23437179 2755940 Positive_regulation CDH2 WIF1 20573255 1856522 Positive_regulation CDH20 AXIN2 25149539 2198539 Positive_regulation CDH20 MAP2K6 23208503 2150472 Positive_regulation CDH20 MSX1 21433221 3171247 Positive_regulation CDH22 AXIN2 25149539 2198479 Positive_regulation CDH22 MAP2K6 23208503 2150322 Positive_regulation CDH22 MSX1 21433221 3171202 Positive_regulation CDH23 AXIN2 25149539 2198483 Positive_regulation CDH23 MAP2K6 23208503 2150332 Positive_regulation CDH23 MSX1 21433221 3171205 Positive_regulation CDH24 AXIN2 25149539 2198487 Positive_regulation CDH24 MAP2K6 23208503 2150342 Positive_regulation CDH24 MSX1 21433221 3171208 Positive_regulation CDH26 AXIN2 25149539 2198491 Positive_regulation CDH26 MAP2K6 23208503 2150352 Positive_regulation CDH26 MSX1 21433221 3171211 Positive_regulation CDH3 AXIN2 25149539 2198543 Positive_regulation CDH3 MAP2K6 23208503 2150482 Positive_regulation CDH3 MSX1 21433221 3171250 Positive_regulation CDH4 AXIN2 25149539 2198547 Positive_regulation CDH4 MAP2K6 23208503 2150492 Positive_regulation CDH4 MSX1 21433221 3171253 Positive_regulation CDH5 ANGPT1 23186009 660385 Positive_regulation CDH5 AXIN2 25149539 2198551 Positive_regulation CDH5 CHI3L1 23665676 2152218 Positive_regulation CDH5 CHI3L1 23665676 2152219 Positive_regulation CDH5 CHI3L1 23665676 2152231 Positive_regulation CDH5 MAP2K6 23208503 2150502 Positive_regulation CDH5 MMP28 20139113 513585 Positive_regulation CDH5 MMP7 20139113 513600 Positive_regulation CDH5 MSX1 21433221 3171256 Positive_regulation CDH5 TNF 20308428 1373820 Positive_regulation CDH5 TNF 20308428 1373832 Positive_regulation CDH5 TNF 20871620 11942 Positive_regulation CDH5 TNF 21569331 1229088 Positive_regulation CDH5 TNF 22144946 928810 Positive_regulation CDH5 TNF 22720111 2371293 Positive_regulation CDH6 AXIN2 25149539 2198555 Positive_regulation CDH6 ID1 24069422 2853340 Positive_regulation CDH6 ID1 24069422 2853343 Positive_regulation CDH6 MAP2K6 23208503 2150512 Positive_regulation CDH6 MSX1 21433221 3171259 Positive_regulation CDH7 AXIN2 25149539 2198559 Positive_regulation CDH7 MAP2K6 23208503 2150522 Positive_regulation CDH7 MSX1 21433221 3171262 Positive_regulation CDH8 AXIN2 25149539 2198563 Positive_regulation CDH8 MAP2K6 23208503 2150532 Positive_regulation CDH8 MSX1 21433221 3171265 Positive_regulation CDH9 AXIN2 25149539 2198567 Positive_regulation CDH9 MAP2K6 23208503 2150542 Positive_regulation CDH9 MSX1 21433221 3171268 Positive_regulation CDHR3 MAP3K11 24811194 1768826 Positive_regulation CDK1 CCND1 18700973 463066 Positive_regulation CDK1 CCND1 PMC2198854 1475391 Positive_regulation CDK1 EPHB2 19891779 464975 Positive_regulation CDK1 EPHB2 22087839 681991 Positive_regulation CDK1 EPHB2 23936173 2829604 Positive_regulation CDK1 ID1 24572994 1142518 Positive_regulation CDK1 IFI27 16759351 579666 Positive_regulation CDK1 IFI27 21606086 805436 Positive_regulation CDK1 IFI27 25392689 490149 Positive_regulation CDK1 IGFBP1 21795390 1792886 Positive_regulation CDK1 MAP2K6 10769017 1257039 Positive_regulation CDK1 MAP2K6 11238451 1267596 Positive_regulation CDK1 NES 15251038 277769 Positive_regulation CDK10 CCND1 18700973 463068 Positive_regulation CDK10 CCND1 PMC2198854 1475393 Positive_regulation CDK10 EPHB2 23936173 2829606 Positive_regulation CDK10 IFI27 21606086 805438 Positive_regulation CDK12 CCND1 18700973 463079 Positive_regulation CDK12 CCND1 PMC2198854 1475404 Positive_regulation CDK12 EPHB2 23936173 2829618 Positive_regulation CDK12 IFI27 21606086 805449 Positive_regulation CDK13 CCND1 18700973 463067 Positive_regulation CDK13 CCND1 PMC2198854 1475392 Positive_regulation CDK13 EPHB2 23936173 2829605 Positive_regulation CDK13 IFI27 21606086 805437 Positive_regulation CDK14 CCND1 18700973 463083 Positive_regulation CDK14 CCND1 PMC2198854 1475408 Positive_regulation CDK14 EPHB2 23936173 2829622 Positive_regulation CDK14 IFI27 21606086 805453 Positive_regulation CDK15 CCND1 18700973 463065 Positive_regulation CDK15 CCND1 PMC2198854 1475390 Positive_regulation CDK15 EPHB2 23936173 2829603 Positive_regulation CDK15 IFI27 21606086 805435 Positive_regulation CDK16 CCND1 18700973 463080 Positive_regulation CDK16 CCND1 PMC2198854 1475405 Positive_regulation CDK16 EPHB2 23936173 2829619 Positive_regulation CDK16 IFI27 21606086 805450 Positive_regulation CDK17 CCND1 18700973 463081 Positive_regulation CDK17 CCND1 PMC2198854 1475406 Positive_regulation CDK17 EPHB2 23936173 2829620 Positive_regulation CDK17 IFI27 21606086 805451 Positive_regulation CDK18 CCND1 18700973 463082 Positive_regulation CDK18 CCND1 PMC2198854 1475407 Positive_regulation CDK18 EPHB2 23936173 2829621 Positive_regulation CDK18 IFI27 21606086 805452 Positive_regulation CDK19 CCND1 18700973 463077 Positive_regulation CDK19 CCND1 PMC2198854 1475402 Positive_regulation CDK19 EDN2 9792333 1763678 Positive_regulation CDK19 EPHB2 12769834 369128 Positive_regulation CDK19 EPHB2 22216095 2584368 Positive_regulation CDK19 EPHB2 22817771 471920 Positive_regulation CDK19 EPHB2 23936173 2829616 Positive_regulation CDK19 IFI27 21606086 805447 Positive_regulation CDK19 RCAN1 19124655 1553410 Positive_regulation CDK19 TLR7 18584038 3072915 Positive_regulation CDK19 TLR7 18584038 3073667 Positive_regulation CDK19 TLR7 18815618 631565 Positive_regulation CDK19 TLR7 20871832 1748066 Positive_regulation CDK19 TLR7 22785227 1919069 Positive_regulation CDK19 TNF 22566867 899032 Positive_regulation CDK19 TNF 23824685 2809188 Positive_regulation CDK19 TNF 24300561 2247607 Positive_regulation CDK19 TNF 24971461 2984445 Positive_regulation CDK19 TNF 25275456 2373028 Positive_regulation CDK19 TNF 3435705 443408 Positive_regulation CDK19 TNF 7540649 1590327 Positive_regulation CDK2 CCND1 16863592 580008 Positive_regulation CDK2 CCND1 17521451 290857 Positive_regulation CDK2 CCND1 18700973 463069 Positive_regulation CDK2 CCND1 18927618 2398444 Positive_regulation CDK2 CCND1 21368870 550817 Positive_regulation CDK2 CCND1 22504904 14683 Positive_regulation CDK2 CCND1 23320178 1065265 Positive_regulation CDK2 CCND1 23320178 1065266 Positive_regulation CDK2 CCND1 23390492 2750674 Positive_regulation CDK2 CCND1 8609171 1451007 Positive_regulation CDK2 CCND1 8609171 1451039 Positive_regulation CDK2 CCND1 9026502 1459171 Positive_regulation CDK2 CCND1 PMC2198854 1475394 Positive_regulation CDK2 CDKN1C 23985559 2184704 Positive_regulation CDK2 EPHB2 17319972 1645286 Positive_regulation CDK2 EPHB2 19665013 698143 Positive_regulation CDK2 EPHB2 23936173 2829607 Positive_regulation CDK2 F2R 17319972 1645287 Positive_regulation CDK2 FAS 10075979 1511241 Positive_regulation CDK2 IFI27 17088910 428307 Positive_regulation CDK2 IFI27 17088910 428343 Positive_regulation CDK2 IFI27 17565690 1846555 Positive_regulation CDK2 IFI27 17724117 1343493 Positive_regulation CDK2 IFI27 18477650 505692 Positive_regulation CDK2 IFI27 18922157 1503344 Positive_regulation CDK2 IFI27 21255415 586049 Positive_regulation CDK2 IFI27 21606086 805439 Positive_regulation CDK2 IFI27 22417103 587252 Positive_regulation CDK2 IFI27 23055977 959144 Positive_regulation CDK2 IFI27 23843843 1238240 Positive_regulation CDK2 IFI27 24104967 442042 Positive_regulation CDK2 IFI27 9548727 1467109 Positive_regulation CDK2 MAP2K6 21079779 2481886 Positive_regulation CDK2 SPHK1 23028939 2693654 Positive_regulation CDK2 TNF 24013271 2842018 Positive_regulation CDK20 CCND1 18700973 463078 Positive_regulation CDK20 CCND1 PMC2198854 1475403 Positive_regulation CDK20 EPHB2 23936173 2829617 Positive_regulation CDK20 IFI27 21606086 805448 Positive_regulation CDK3 CCND1 18700973 463070 Positive_regulation CDK3 CCND1 PMC2198854 1475395 Positive_regulation CDK3 EPHB2 23936173 2829608 Positive_regulation CDK3 IFI27 21606086 805440 Positive_regulation CDK4 CCND1 16863592 580006 Positive_regulation CDK4 CCND1 17535444 300045 Positive_regulation CDK4 CCND1 17576439 686242 Positive_regulation CDK4 CCND1 18194538 250686 Positive_regulation CDK4 CCND1 18700973 463071 Positive_regulation CDK4 CCND1 18764945 583287 Positive_regulation CDK4 CCND1 19767775 2127062 Positive_regulation CDK4 CCND1 19865540 1088922 Positive_regulation CDK4 CCND1 21272329 586053 Positive_regulation CDK4 CCND1 21860617 696751 Positive_regulation CDK4 CCND1 22504904 14684 Positive_regulation CDK4 CCND1 22606291 2642824 Positive_regulation CDK4 CCND1 23028659 2692330 Positive_regulation CDK4 CCND1 23093837 1225144 Positive_regulation CDK4 CCND1 23181557 292648 Positive_regulation CDK4 CCND1 23390492 2750673 Positive_regulation CDK4 CCND1 23708653 2152337 Positive_regulation CDK4 CCND1 24444383 271280 Positive_regulation CDK4 CCND1 24849787 2972878 Positive_regulation CDK4 CCND1 24884417 273071 Positive_regulation CDK4 CCND1 24970807 2193958 Positive_regulation CDK4 CCND1 25344914 2206024 Positive_regulation CDK4 CCND1 PMC2198854 1475396 Positive_regulation CDK4 CCND1 PMC3300140 476960 Positive_regulation CDK4 CCND1 PMC4271004 1675269 Positive_regulation CDK4 CDKN1C 23985559 2184706 Positive_regulation CDK4 EPHB2 23936173 2829609 Positive_regulation CDK4 F2R 17319972 1645277 Positive_regulation CDK4 FAS 23237220 625272 Positive_regulation CDK4 HBEGF 22873932 533056 Positive_regulation CDK4 IFI27 11381079 1270255 Positive_regulation CDK4 IFI27 18477650 505694 Positive_regulation CDK4 IFI27 21606086 805441 Positive_regulation CDK4 IFI27 23843843 1238242 Positive_regulation CDK4 IFI27 25486097 3032734 Positive_regulation CDK4 MAP2K6 17092340 580235 Positive_regulation CDK4 OSR1 24931004 1681291 Positive_regulation CDK4 OSR1 24931004 1681320 Positive_regulation CDK4 TNF 24302570 752148 Positive_regulation CDK5 CAPN8 19151707 1922113 Positive_regulation CDK5 CAPN8 19151707 1922129 Positive_regulation CDK5 CAPN8 19419557 1891233 Positive_regulation CDK5 CAPN8 20508838 2001869 Positive_regulation CDK5 CAPN8 21902831 3160627 Positive_regulation CDK5 CAPN8 21943307 1892475 Positive_regulation CDK5 CAPN8 23759582 543510 Positive_regulation CDK5 CCND1 18700973 463072 Positive_regulation CDK5 CCND1 PMC2198854 1475397 Positive_regulation CDK5 EPHB2 20673369 1857783 Positive_regulation CDK5 EPHB2 23936173 2829610 Positive_regulation CDK5 EPHB2 24498195 2918895 Positive_regulation CDK5 EPHB2 24498195 2918901 Positive_regulation CDK5 EPHB2 24498195 2918905 Positive_regulation CDK5 EPHB2 24498195 2918919 Positive_regulation CDK5 IFI27 21566658 547252 Positive_regulation CDK5 IFI27 21606086 805442 Positive_regulation CDK5 NES 20174467 2441418 Positive_regulation CDK5 NES 21278733 1966517 Positive_regulation CDK5 NES 21278733 1966518 Positive_regulation CDK5 NES 21278733 1966533 Positive_regulation CDK5 NES 21278733 1966534 Positive_regulation CDK5 NES 21278733 1966540 Positive_regulation CDK5 NES 21346193 1788638 Positive_regulation CDK5 NES 21346193 1788640 Positive_regulation CDK5 TNF 21736731 1898344 Positive_regulation CDK5 TNF 21736731 1898358 Positive_regulation CDK5R1 CCND1 22833568 1806094 Positive_regulation CDK5RAP2 NES 15251038 277774 Positive_regulation CDK5RAP3 ANKRD1 23504458 1206655 Positive_regulation CDK6 CCND1 18700973 463073 Positive_regulation CDK6 CCND1 19863813 584385 Positive_regulation CDK6 CCND1 21272329 586054 Positive_regulation CDK6 CCND1 23028659 2692331 Positive_regulation CDK6 CCND1 23151022 266839 Positive_regulation CDK6 CCND1 23181557 292650 Positive_regulation CDK6 CCND1 25344914 2206025 Positive_regulation CDK6 CCND1 PMC2198854 1475398 Positive_regulation CDK6 EPHB2 23936173 2829611 Positive_regulation CDK6 HBEGF 22873932 533058 Positive_regulation CDK6 IFI27 21606086 805443 Positive_regulation CDK7 CCND1 18700973 463074 Positive_regulation CDK7 CCND1 PMC2198854 1475399 Positive_regulation CDK7 EPHB2 23936173 2829612 Positive_regulation CDK7 IFI27 21606086 805444 Positive_regulation CDK7 IFI27 24511319 825183 Positive_regulation CDK8 CCND1 18700973 463075 Positive_regulation CDK8 CCND1 PMC2198854 1475400 Positive_regulation CDK8 EDN2 9792333 1763672 Positive_regulation CDK8 EPHB2 12769834 369126 Positive_regulation CDK8 EPHB2 22216095 2584366 Positive_regulation CDK8 EPHB2 22319481 860847 Positive_regulation CDK8 EPHB2 22817771 471912 Positive_regulation CDK8 EPHB2 23936173 2829613 Positive_regulation CDK8 EPHB2 24045785 3137171 Positive_regulation CDK8 IFI27 21606086 805445 Positive_regulation CDK8 RCAN1 19124655 1553408 Positive_regulation CDK8 TLR7 18584038 3072895 Positive_regulation CDK8 TLR7 18584038 3073647 Positive_regulation CDK8 TLR7 18815618 631545 Positive_regulation CDK8 TLR7 20871832 1748046 Positive_regulation CDK8 TLR7 22785227 1919047 Positive_regulation CDK8 TNF 22566867 899030 Positive_regulation CDK8 TNF 23824685 2809186 Positive_regulation CDK8 TNF 24300561 2247605 Positive_regulation CDK8 TNF 24971461 2984439 Positive_regulation CDK8 TNF 25275456 2373026 Positive_regulation CDK8 TNF 3435705 443406 Positive_regulation CDK8 TNF 7540649 1590325 Positive_regulation CDK9 CCND1 18700973 463076 Positive_regulation CDK9 CCND1 PMC2198854 1475401 Positive_regulation CDK9 EPHB2 23658523 3061158 Positive_regulation CDK9 EPHB2 23936173 2829614 Positive_regulation CDK9 EPHB2 24643025 2935545 Positive_regulation CDK9 FAS 23056264 2700757 Positive_regulation CDK9 FAS 23056264 2700765 Positive_regulation CDK9 IFI27 21606086 805446 Positive_regulation CDK9 JAG1 19015152 2037571 Positive_regulation CDK9 MUC16 22132309 1680433 Positive_regulation CDK9 RNASE1 22379134 2073088 Positive_regulation CDK9 STAT4 25259790 3010670 Positive_regulation CDK9 STK39 22860019 2671116 Positive_regulation CDK9 TNF 24957606 2102193 Positive_regulation CDKN1A CAPN8 24886575 3124720 Positive_regulation CDKN1A CCND1 10952788 417702 Positive_regulation CDKN1A CCND1 10952788 417755 Positive_regulation CDKN1A CCND1 11134071 1266106 Positive_regulation CDKN1A CCND1 11161387 418291 Positive_regulation CDKN1A CCND1 11250701 455657 Positive_regulation CDKN1A CCND1 11259090 418393 Positive_regulation CDKN1A CCND1 17948060 763211 Positive_regulation CDKN1A CCND1 18237383 250710 Positive_regulation CDKN1A CCND1 20180967 584470 Positive_regulation CDKN1A CCND1 20576128 256483 Positive_regulation CDKN1A CCND1 20684793 1504430 Positive_regulation CDKN1A CCND1 20813052 1858381 Positive_regulation CDKN1A CCND1 22481926 1673478 Positive_regulation CDKN1A CCND1 22860097 2671569 Positive_regulation CDKN1A CCND1 22860097 2671572 Positive_regulation CDKN1A CCND1 22860097 2671587 Positive_regulation CDKN1A CCND1 23006512 1698860 Positive_regulation CDKN1A CCND1 23181557 292652 Positive_regulation CDKN1A CCND1 23300840 2736185 Positive_regulation CDKN1A CCND1 23340319 2117184 Positive_regulation CDKN1A CCND1 23344177 1905721 Positive_regulation CDKN1A CCND1 23390492 2750693 Positive_regulation CDKN1A CCND1 23390492 2750695 Positive_regulation CDKN1A CCND1 23755177 2801664 Positive_regulation CDKN1A CCND1 23843843 1238243 Positive_regulation CDKN1A CCND1 24438088 271174 Positive_regulation CDKN1A CCND1 24747418 2955863 Positive_regulation CDKN1A CCND1 25164084 1484583 Positive_regulation CDKN1A CCND1 25477755 657798 Positive_regulation CDKN1A CCND1 9864370 1473427 Positive_regulation CDKN1A CCND1 PMC3300260 476988 Positive_regulation CDKN1A CTGF 22684333 541550 Positive_regulation CDKN1A EPHB2 10491389 1249382 Positive_regulation CDKN1A EPHB2 10491389 1249383 Positive_regulation CDKN1A EPHB2 10491389 1249394 Positive_regulation CDKN1A EPHB2 10491389 1249395 Positive_regulation CDKN1A EPHB2 10491389 1249396 Positive_regulation CDKN1A EPHB2 10491389 1249411 Positive_regulation CDKN1A EPHB2 10491389 1249412 Positive_regulation CDKN1A EPHB2 10491389 1249417 Positive_regulation CDKN1A EPHB2 10491389 1249427 Positive_regulation CDKN1A EPHB2 11134071 1266110 Positive_regulation CDKN1A EPHB2 16351709 1844993 Positive_regulation CDKN1A EPHB2 16351709 1844994 Positive_regulation CDKN1A EPHB2 16351709 1844995 Positive_regulation CDKN1A EPHB2 16351709 1845002 Positive_regulation CDKN1A EPHB2 19068119 281915 Positive_regulation CDKN1A EPHB2 19068119 281941 Positive_regulation CDKN1A EPHB2 19068119 281942 Positive_regulation CDKN1A EPHB2 19068119 281944 Positive_regulation CDKN1A EPHB2 19703290 1625534 Positive_regulation CDKN1A EPHB2 20813052 1858395 Positive_regulation CDKN1A EPHB2 20855497 1560268 Positive_regulation CDKN1A EPHB2 20855497 1560269 Positive_regulation CDKN1A EPHB2 20855497 1560274 Positive_regulation CDKN1A EPHB2 23434831 1729670 Positive_regulation CDKN1A EPHB2 23542180 218397 Positive_regulation CDKN1A EPHB2 23573093 1069209 Positive_regulation CDKN1A EPHB2 23936173 2829615 Positive_regulation CDKN1A EPHB2 23991123 2841118 Positive_regulation CDKN1A EPHB2 9864370 1473428 Positive_regulation CDKN1A FOXO1 18312651 462652 Positive_regulation CDKN1A FOXO1 22123859 1394150 Positive_regulation CDKN1A FOXO1 23614736 830004 Positive_regulation CDKN1A FOXO1 24886245 1874791 Positive_regulation CDKN1A FOXO1 24891760 1759362 Positive_regulation CDKN1A ID1 20003244 254757 Positive_regulation CDKN1A ID1 20842131 435944 Positive_regulation CDKN1A ID1 22139302 1879319 Positive_regulation CDKN1A ID1 22139302 1879352 Positive_regulation CDKN1A ID1 22139302 1879407 Positive_regulation CDKN1A ID1 22139302 1879459 Positive_regulation CDKN1A ID1 23342268 491925 Positive_regulation CDKN1A ID1 23342268 491928 Positive_regulation CDKN1A ID1 23342268 491930 Positive_regulation CDKN1A ID1 23342268 491932 Positive_regulation CDKN1A ID1 23342268 491940 Positive_regulation CDKN1A ID1 23517130 268087 Positive_regulation CDKN1A IFI27 17565690 1846547 Positive_regulation CDKN1A IFI27 18477650 505695 Positive_regulation CDKN1A IFI27 19025580 1503409 Positive_regulation CDKN1A IFI27 22242193 2587433 Positive_regulation CDKN1A IFI27 24104967 442043 Positive_regulation CDKN1A IFI27 25609158 1511057 Positive_regulation CDKN1A IFI27 25609158 1511076 Positive_regulation CDKN1A JAG1 17325209 1337596 Positive_regulation CDKN1A MAP2K6 10491389 1249441 Positive_regulation CDKN1A MAP2K6 16351709 1845010 Positive_regulation CDKN1A MAP2K6 22531632 438565 Positive_regulation CDKN1A MAP2K6 24820097 2968870 Positive_regulation CDKN1A MATN2 24691449 2947769 Positive_regulation CDKN1A MATN2 24895400 1487947 Positive_regulation CDKN1A NGFR 23660869 3135735 Positive_regulation CDKN1A OSR1 24931004 1681292 Positive_regulation CDKN1A PLAU 21423677 798528 Positive_regulation CDKN1A PLAU 21592330 411496 Positive_regulation CDKN1A S100B 25536222 3035763 Positive_regulation CDKN1A TNF 17565690 1846525 Positive_regulation CDKN1A TNF 17565690 1846526 Positive_regulation CDKN1A TNF 17565690 1846527 Positive_regulation CDKN1A TNF 17565690 1846536 Positive_regulation CDKN1A TNF 17565690 1846537 Positive_regulation CDKN1A TNF 17565690 1846542 Positive_regulation CDKN1A TNF 17565690 1846543 Positive_regulation CDKN1A TNF 17565690 1846544 Positive_regulation CDKN1A TNF 17565690 1846551 Positive_regulation CDKN1A TNF 19580462 1236591 Positive_regulation CDKN1A TNF 21624135 1862320 Positive_regulation CDKN1A TNF 23122182 292593 Positive_regulation CDKN1A TNF 23263670 1100099 Positive_regulation CDKN1A TNF 24201806 568936 Positive_regulation CDKN1A TP63 20123734 2051931 Positive_regulation CDKN1A WIF1 24853424 576262 Positive_regulation CDKN1A WIF1 24853424 576268 Positive_regulation CDKN1B CCND1 20459741 1855043 Positive_regulation CDKN1B CCND1 23300840 2736186 Positive_regulation CDKN1B CCND1 23807222 563491 Positive_regulation CDKN1B CCND1 25352248 1999023 Positive_regulation CDKN1B CDKN1C 17559664 1999813 Positive_regulation CDKN1B F2R 17319972 1645278 Positive_regulation CDKN1B FOXO1 18312651 462665 Positive_regulation CDKN1B FOXO1 20668652 2457222 Positive_regulation CDKN1B FOXO1 20668652 2457240 Positive_regulation CDKN1B FOXO1 20668652 2457259 Positive_regulation CDKN1B FOXO1 22123859 1394154 Positive_regulation CDKN1B FOXO1 23872064 145322 Positive_regulation CDKN1B FOXO1 23874926 2823659 Positive_regulation CDKN1B ID1 20842131 435946 Positive_regulation CDKN1B IFI27 23853725 1153306 Positive_regulation CDKN1B TNF 17565690 1846530 Positive_regulation CDKN1C BCL11B 20824091 2473673 Positive_regulation CDKN1C BCL11B 22588081 771826 Positive_regulation CDKN1C BCL11B 25408871 608441 Positive_regulation CDKN1C CDKN1B 17559664 1999814 Positive_regulation CDKN1C CKAP4 19221586 2405777 Positive_regulation CDKN1C COPS2 23287466 542601 Positive_regulation CDKN1C COPS3 23287466 542598 Positive_regulation CDKN1C COPS4 23287466 542596 Positive_regulation CDKN1C COPS5 23287466 542599 Positive_regulation CDKN1C COPS6 23287466 542597 Positive_regulation CDKN1C COPS6 23470457 543093 Positive_regulation CDKN1C COPS8 23287466 542600 Positive_regulation CDKN1C E2F1 20824091 2473686 Positive_regulation CDKN1C EGR1 23087602 937487 Positive_regulation CDKN1C EZH2 19340297 2411489 Positive_regulation CDKN1C EZH2 19340297 2411490 Positive_regulation CDKN1C EZH2 19340297 2411496 Positive_regulation CDKN1C FHL2 19417068 2043671 Positive_regulation CDKN1C FHL2 19417068 2043681 Positive_regulation CDKN1C FHL2 19417068 2043695 Positive_regulation CDKN1C FHL2 19417068 2043700 Positive_regulation CDKN1C FOXL2 23029457 2697643 Positive_regulation CDKN1C FOXO3 18312651 462703 Positive_regulation CDKN1C H19 22844132 1641303 Positive_regulation CDKN1C HDAC1 19221586 2405792 Positive_regulation CDKN1C HDAC10 19221586 2405790 Positive_regulation CDKN1C HDAC11 19221586 2405791 Positive_regulation CDKN1C HDAC2 19221586 2405793 Positive_regulation CDKN1C HDAC3 19221586 2405794 Positive_regulation CDKN1C HDAC4 19221586 2405785 Positive_regulation CDKN1C HDAC5 19221586 2405789 Positive_regulation CDKN1C HDAC6 19221586 2405786 Positive_regulation CDKN1C HDAC7 19221586 2405788 Positive_regulation CDKN1C HDAC8 19221586 2405784 Positive_regulation CDKN1C HDAC9 19221586 2405787 Positive_regulation CDKN1C HRAS 20105280 303660 Positive_regulation CDKN1C IGF2 23154539 799600 Positive_regulation CDKN1C ING1 23472054 2282149 Positive_regulation CDKN1C INSM1 23000964 1928611 Positive_regulation CDKN1C INSM1 23000964 1928612 Positive_regulation CDKN1C INSM1 23000964 1928613 Positive_regulation CDKN1C ITSN2 23472054 2282150 Positive_regulation CDKN1C ITSN2 23472054 2282171 Positive_regulation CDKN1C JAG1 19816565 3045475 Positive_regulation CDKN1C KCNQ1OT1 20673338 243804 Positive_regulation CDKN1C KCNQ1OT1 22205991 2584030 Positive_regulation CDKN1C KRAS 20105280 303661 Positive_regulation CDKN1C MIR221 21278784 12421 Positive_regulation CDKN1C MYLIP 21278784 12427 Positive_regulation CDKN1C MYLIP 21278784 12432 Positive_regulation CDKN1C MYLIP 21278784 12433 Positive_regulation CDKN1C MYLIP 21278784 12434 Positive_regulation CDKN1C NAP1L1 25071868 803794 Positive_regulation CDKN1C NR4A2 23087602 937488 Positive_regulation CDKN1C NRAS 20105280 303662 Positive_regulation CDKN1C PCNA 17505532 2376110 Positive_regulation CDKN1C PCNA 24098681 2858295 Positive_regulation CDKN1C PRDX2 19340297 2411494 Positive_regulation CDKN1C PRDX2 19340297 2411497 Positive_regulation CDKN1C PRDX2 19340297 2411498 Positive_regulation CDKN1C PRDX2 19340297 2411503 Positive_regulation CDKN1C PROX1 20105280 303663 Positive_regulation CDKN1C SEC14L2 25374842 948814 Positive_regulation CDKN1C SIK1 20140255 2440222 Positive_regulation CDKN1C SKP2 23470457 543095 Positive_regulation CDKN1C SMARCB1 19221586 2405770 Positive_regulation CDKN1C SMARCB1 19221586 2405776 Positive_regulation CDKN1C SMARCB1 19221586 2405782 Positive_regulation CDKN1C SMARCB1 19221586 2405783 Positive_regulation CDKN1C TCF3 19417068 2043680 Positive_regulation CDKN1C XIST 24979243 1942954 Positive_regulation CDKN2A CCND1 22860097 2671574 Positive_regulation CDKN2A CCND1 22860097 2671597 Positive_regulation CDKN2A CCND1 22988546 941271 Positive_regulation CDKN2A CCND1 24212955 499345 Positive_regulation CDKN2A CCND1 24741325 487758 Positive_regulation CDKN2A CTGF 22684333 541551 Positive_regulation CDKN2A EPHB2 21836819 648251 Positive_regulation CDKN2A ID1 20842131 435929 Positive_regulation CDKN2A ID1 20842131 435930 Positive_regulation CDKN2A ID1 20842131 435939 Positive_regulation CDKN2A ID1 20842131 435942 Positive_regulation CDKN2A IL1B 23520533 2769034 Positive_regulation CDKN2A IL1B 24572376 131949 Positive_regulation CDKN2A MAP2K6 21836819 648257 Positive_regulation CDKN2A S100A7 25621169 1727229 Positive_regulation CDKN2A S100A7 25621169 1727244 Positive_regulation CDKN2A TNF 21187925 2489303 Positive_regulation CDKN2A TNF 21738489 2325070 Positive_regulation CDKN2B CCND1 18021445 250617 Positive_regulation CDKN2B CCND1 23300840 2736187 Positive_regulation CDKN2B EPHB2 23237773 2181998 Positive_regulation CDKN2B FOXO1 24891760 1759383 Positive_regulation CDO1 EPHB2 22298426 1799989 Positive_regulation CEACAM5 TNF 9820179 447956 Positive_regulation CEACAM6 COX10 21108829 286036 Positive_regulation CEACAM6 EDN1 18472935 1743246 Positive_regulation CEACAM6 IL6 17764466 590523 Positive_regulation CEACAM6 L1CAM PMC4212306 3206508 Positive_regulation CEACAM6 MAPK1 22905257 2675868 Positive_regulation CEACAM6 MAPK3 22905257 2675869 Positive_regulation CEACAM6 PAEP 18412945 250830 Positive_regulation CEACAM6 SCO1 21108829 286035 Positive_regulation CEACAM6 SEA 25050114 1226931 Positive_regulation CEACAM6 SLC22A3 25398131 3027580 Positive_regulation CEACAM6 SLC22A3 25398131 3027607 Positive_regulation CEACAM6 SRC 25398131 3027581 Positive_regulation CEACAM6 TRIM27 18336069 2264307 Positive_regulation CEACAM6 TRIM27 18336069 2264319 Positive_regulation CEACAM6 TRNAA1 19426454 235164 Positive_regulation CEACAM6 UNC80 18336069 2264305 Positive_regulation CEACAM6 UNC80 18336069 2264306 Positive_regulation CEACAM6 UNC80 18336069 2264313 Positive_regulation CEACAM6 UNC80 18336069 2264314 Positive_regulation CEACAM6 UNC80 18336069 2264318 Positive_regulation CEACAM6 UNC80 18336069 2264320 Positive_regulation CEBPA BPI 24658030 2937317 Positive_regulation CEBPA CD14 22879381 2080314 Positive_regulation CEBPA EPHB2 22035226 528002 Positive_regulation CEBPA FOXO1 23285067 2732377 Positive_regulation CEBPA FOXO1 23843680 1753847 Positive_regulation CEBPA RGS2 23936658 1719160 Positive_regulation CEBPA TNF 10098766 414109 Positive_regulation CEBPA TNF 10098766 414111 Positive_regulation CEBPB TLR7 17724128 1546884 Positive_regulation CEBPB TLR7 17724128 1546904 Positive_regulation CEBPB TNF 21283687 2497291 Positive_regulation CEBPB TNF 24330637 1703404 Positive_regulation CEBPB TNF 24330637 1703409 Positive_regulation CEBPD TNF 23525087 1958647 Positive_regulation CEBPD TNF 23725043 3207885 Positive_regulation CEL TNF 11790894 735818 Positive_regulation CELF1 RNASE1 19443441 2046144 Positive_regulation CENPJ NES 15251038 277770 Positive_regulation CEP135 NES 15251038 277792 Positive_regulation CEP152 NES 15251038 277796 Positive_regulation CEP164 NES 15251038 277794 Positive_regulation CEP192 NES 15251038 277779 Positive_regulation CEP250 NES 15251038 277772 Positive_regulation CEP290 NES 15251038 277790 Positive_regulation CEP57 NES 15251038 277800 Positive_regulation CEP63 NES 15251038 277785 Positive_regulation CEP70 NES 15251038 277799 Positive_regulation CEP72 NES 15251038 277781 Positive_regulation CEP76 NES 15251038 277783 Positive_regulation CEP78 NES 15251038 277784 Positive_regulation CETN2 NES 15251038 277773 Positive_regulation CETP LIPG 22431312 778566 Positive_regulation CFB TNF 22547990 3152628 Positive_regulation CFI C4BPA 7019379 1586825 Positive_regulation CFI CDK2 21690308 1389385 Positive_regulation CFL1 MAP2K6 24117811 1043124 Positive_regulation CFL1 NES 21682918 1862498 Positive_regulation CFL1 SCIN 24155741 879370 Positive_regulation CFL1 TNFSF10 20646307 256700 Positive_regulation CFL2 MAP2K6 24117811 1043134 Positive_regulation CFL2 NES 21682918 1862500 Positive_regulation CFL2 SCIN 24155741 879372 Positive_regulation CFLAR EPHB2 11157988 1267373 Positive_regulation CFLAR EPHB2 25019384 2988852 Positive_regulation CFLAR EPHB2 25025076 194748 Positive_regulation CFLAR FAS 24595238 1124490 Positive_regulation CFLAR MUC16 24690311 272534 Positive_regulation CFLAR MUC16 24690311 272535 Positive_regulation CFLAR TNF 15138489 424517 Positive_regulation CFLAR TNF 22089168 553478 Positive_regulation CFLAR TNFSF10 20062539 2436810 Positive_regulation CFLAR TNFSF10 20062539 2436818 Positive_regulation CFLAR TNFSF10 20663232 1857139 Positive_regulation CFLAR TNFSF10 22675673 940820 Positive_regulation CFLAR TNFSF10 22932446 834910 Positive_regulation CFLAR TNFSF10 22932446 834917 Positive_regulation CFLAR TNFSF10 24690311 272603 Positive_regulation CFP JAG1 6193221 1585020 Positive_regulation CFP JAG1 6193221 1585021 Positive_regulation CFP KRT38 12499352 1290329 Positive_regulation CFP RIC3 23586521 388451 Positive_regulation CFP RIC3 23586521 388452 Positive_regulation CFP TNF 24349220 2897189 Positive_regulation CFP TNF 24349220 2897191 Positive_regulation CFTR ANO1 24478713 963497 Positive_regulation CFTR CAPN8 23785472 2806333 Positive_regulation CFTR CAPN8 23785472 2806347 Positive_regulation CFTR FOXA1 25081205 2103522 Positive_regulation CFTR IL1B 22046295 2566413 Positive_regulation CFTR MIP 24671173 2946556 Positive_regulation CFTR MIP 24671173 2946577 Positive_regulation CFTR TNF 19847291 2429187 Positive_regulation CFTR TNF 19847291 2429241 Positive_regulation CGA EPHB2 25352775 939267 Positive_regulation CGA FOXO1 25423188 3030044 Positive_regulation CGB8 EPHB2 25352775 939266 Positive_regulation CGB8 FOXO1 25423188 3030043 Positive_regulation CGN TNF 20072622 2436882 Positive_regulation CH25H TLR7 24069554 1706875 Positive_regulation CHAF1A ETV7 22291956 2591498 Positive_regulation CHAF1B ETV7 22291956 2591499 Positive_regulation CHAT TNF 23840379 2812657 Positive_regulation CHAT TNF 23840379 2812658 Positive_regulation CHAT TNF 23840379 2812668 Positive_regulation CHAT WNT7A 25170755 3003826 Positive_regulation CHAT WNT7A 25170755 3003905 Positive_regulation CHDH PRODH 24410747 394814 Positive_regulation CHEK2 EPHB2 23839489 441238 Positive_regulation CHEK2 TNFSF10 21092294 1860276 Positive_regulation CHGA RNASE1 25101113 896636 Positive_regulation CHGA RNASE7 25101113 896644 Positive_regulation CHGA TNF 22470519 2614505 Positive_regulation CHI3L1 AKT1 23972995 608949 Positive_regulation CHI3L1 AKT2 23972995 608950 Positive_regulation CHI3L1 AKT3 23972995 608951 Positive_regulation CHI3L1 AVP 19662198 178050 Positive_regulation CHI3L1 CD80 7500044 1588514 Positive_regulation CHI3L1 CDH5 23665676 2152232 Positive_regulation CHI3L1 CRK 19930630 507962 Positive_regulation CHI3L1 CXCL2 24399973 963264 Positive_regulation CHI3L1 DNM1 25347775 3019987 Positive_regulation CHI3L1 DNM2 25347775 3019988 Positive_regulation CHI3L1 DNM3 25347775 3019986 Positive_regulation CHI3L1 EGFR 21274454 1218927 Positive_regulation CHI3L1 EGFR 21274454 1218928 Positive_regulation CHI3L1 EGFR 21274454 1219010 Positive_regulation CHI3L1 GORASP1 23226395 2724426 Positive_regulation CHI3L1 GORASP1 23226395 2724430 Positive_regulation CHI3L1 HSD17B4 22642467 275024 Positive_regulation CHI3L1 IL13 21915293 2552897 Positive_regulation CHI3L1 IL13 23283176 3225438 Positive_regulation CHI3L1 IL13 24416647 1708176 Positive_regulation CHI3L1 IL18 21915293 2552902 Positive_regulation CHI3L1 IL1A 20029652 178134 Positive_regulation CHI3L1 IL4 24416647 1708177 Positive_regulation CHI3L1 IL6 23840582 2815321 Positive_regulation CHI3L1 IL6 23840582 2815327 Positive_regulation CHI3L1 IL6 24373580 396447 Positive_regulation CHI3L1 IL6 24373580 396448 Positive_regulation CHI3L1 IL6 24958781 1159865 Positive_regulation CHI3L1 IL6 25132728 1760489 Positive_regulation CHI3L1 IL6 25358394 1946492 Positive_regulation CHI3L1 IL8 23755018 961418 Positive_regulation CHI3L1 LTB 7540655 1590366 Positive_regulation CHI3L1 MAPK1 22211103 1058697 Positive_regulation CHI3L1 MAPK1 23665676 2152239 Positive_regulation CHI3L1 MAPK1 23972995 608952 Positive_regulation CHI3L1 MAPK10 23972995 608953 Positive_regulation CHI3L1 MAPK11 23972995 608954 Positive_regulation CHI3L1 MAPK12 23972995 608955 Positive_regulation CHI3L1 MAPK13 23972995 608956 Positive_regulation CHI3L1 MAPK14 23972995 608957 Positive_regulation CHI3L1 MAPK15 23972995 608948 Positive_regulation CHI3L1 MAPK3 23665676 2152240 Positive_regulation CHI3L1 MAPK3 23755018 961348 Positive_regulation CHI3L1 MAPK3 23972995 608958 Positive_regulation CHI3L1 MAPK4 23972995 608959 Positive_regulation CHI3L1 MAPK6 23972995 608960 Positive_regulation CHI3L1 MAPK7 23972995 608961 Positive_regulation CHI3L1 MAPK8 23972995 608962 Positive_regulation CHI3L1 MAPK9 23972995 608963 Positive_regulation CHI3L1 MMP9 24399973 963265 Positive_regulation CHI3L1 MYLIP 25358394 1946497 Positive_regulation CHI3L1 PTHLH 19662198 178051 Positive_regulation CHI3L1 RELB 23451236 2758420 Positive_regulation CHI3L1 RELB 23451236 2758429 Positive_regulation CHI3L1 SCARNA5 24281168 501793 Positive_regulation CHI3L1 SDC1 23755018 961347 Positive_regulation CHI3L1 SHBG 22642467 275023 Positive_regulation CHI3L1 STAT6 24416647 1708175 Positive_regulation CHI3L1 SYT1 23226395 2724424 Positive_regulation CHI3L1 SYT1 23226395 2724425 Positive_regulation CHI3L1 SYT1 23226395 2724427 Positive_regulation CHI3L1 TNF 20029652 178133 Positive_regulation CHI3L1 TNF 24373580 396445 Positive_regulation CHI3L1 TNF 24373580 396446 Positive_regulation CHI3L1 TNF 24809021 947828 Positive_regulation CHI3L1 VEGFA 23755018 961417 Positive_regulation CHI3L1 VEGFA 23755018 961422 Positive_regulation CHI3L1 VEGFA 23755018 961423 Positive_regulation CHI3L1 VEGFA 24878721 2975422 Positive_regulation CHI3L1 VEGFA 24878721 2975424 Positive_regulation CHKA EPHB2 21772273 1933150 Positive_regulation CHKA EPHB2 21772273 1933151 Positive_regulation CHKA EPHB2 25166426 3003721 Positive_regulation CHKA MAP2K6 23085539 2181386 Positive_regulation CHRDL1 ASCL1 24360028 1998859 Positive_regulation CHRDL1 BMP2 19771160 2426920 Positive_regulation CHRDL1 BMP4 17173667 299119 Positive_regulation CHRDL1 HES5 24360028 1998858 Positive_regulation CHRDL1 NHLH1 24360028 1998860 Positive_regulation CHRFAM7A TNF 22916243 2680554 Positive_regulation CHST4 TNF 15752429 350583 Positive_regulation CHST4 TNF 15752429 350586 Positive_regulation CHST4 TNF 15752429 350587 Positive_regulation CHUK ABCG2 25111504 2996237 Positive_regulation CHUK EPHB2 22536447 2622493 Positive_regulation CHUK FOXO1 22649777 939897 Positive_regulation CHUK MAP2K6 22536447 2622499 Positive_regulation CHUK TLR7 19734906 1952890 Positive_regulation CHUK TLR7 19734906 1953018 Positive_regulation CHUK TLR7 20231379 1557674 Positive_regulation CHUK TLR7 20231379 1557758 Positive_regulation CHUK TLR7 21197425 979706 Positive_regulation CHUK TLR7 21874024 1955681 Positive_regulation CHUK TLR7 22095690 1033516 Positive_regulation CHUK TLR7 22984582 2689156 Positive_regulation CHUK TLR7 23508732 906436 Positive_regulation CHUK TLR7 23974100 544237 Positive_regulation CHUK TLR7 24130934 204574 Positive_regulation CHUK TNF 10359587 1511912 Positive_regulation CHUK TNF 10359587 1511913 Positive_regulation CHUK TNF 10359587 1511936 Positive_regulation CHUK TNF 10359587 1511942 Positive_regulation CHUK TNF 10748240 1515105 Positive_regulation CHUK TNF 11238593 1519029 Positive_regulation CHUK TNF 12426136 791300 Positive_regulation CHUK TNF 12426136 791301 Positive_regulation CHUK TNF 17374166 1036262 Positive_regulation CHUK TNF 17548520 1546323 Positive_regulation CHUK TNF 17925009 233618 Positive_regulation CHUK TNF 19343194 2290489 Positive_regulation CHUK TNF 19568602 3231629 Positive_regulation CHUK TNF 20087353 434405 Positive_regulation CHUK TNF 20087353 434411 Positive_regulation CHUK TNF 20205746 1656135 Positive_regulation CHUK TNF 20351780 2444539 Positive_regulation CHUK TNF 20351780 2444561 Positive_regulation CHUK TNF 20351780 2444570 Positive_regulation CHUK TNF 20351780 2444602 Positive_regulation CHUK TNF 20416113 402574 Positive_regulation CHUK TNF 20543835 1964780 Positive_regulation CHUK TNF 20671994 506631 Positive_regulation CHUK TNF 20695076 1142930 Positive_regulation CHUK TNF 21119000 1783911 Positive_regulation CHUK TNF 21119000 1783945 Positive_regulation CHUK TNF 21119000 1783962 Positive_regulation CHUK TNF 21342546 238014 Positive_regulation CHUK TNF 21342546 238030 Positive_regulation CHUK TNF 21342546 238042 Positive_regulation CHUK TNF 21399639 1955166 Positive_regulation CHUK TNF 21699726 1658633 Positive_regulation CHUK TNF 21729324 238217 Positive_regulation CHUK TNF 22069560 3181837 Positive_regulation CHUK TNF 22267916 983517 Positive_regulation CHUK TNF 22351606 778128 Positive_regulation CHUK TNF 22768286 2660402 Positive_regulation CHUK TNF 22768286 2660417 Positive_regulation CHUK TNF 22848449 2669105 Positive_regulation CHUK TNF 22991685 1082674 Positive_regulation CHUK TNF 23042150 1957928 Positive_regulation CHUK TNF 23071583 2702970 Positive_regulation CHUK TNF 23071583 2703083 Positive_regulation CHUK TNF 23071583 2703084 Positive_regulation CHUK TNF 23071583 2703125 Positive_regulation CHUK TNF 23104095 1958285 Positive_regulation CHUK TNF 23284617 2730269 Positive_regulation CHUK TNF 23284617 2730273 Positive_regulation CHUK TNF 23284617 2730276 Positive_regulation CHUK TNF 23419260 1637674 Positive_regulation CHUK TNF 23424624 2755006 Positive_regulation CHUK TNF 23437404 2756809 Positive_regulation CHUK TNF 23437404 2756916 Positive_regulation CHUK TNF 23603982 17459 Positive_regulation CHUK TNF 23603982 17476 Positive_regulation CHUK TNF 23690855 819194 Positive_regulation CHUK TNF 23770847 2152631 Positive_regulation CHUK TNF 24260470 2884426 Positive_regulation CHUK TNF 24386331 2903492 Positive_regulation CHUK TNF 24386331 2903531 Positive_regulation CHUK TNF 24386633 186128 Positive_regulation CHUK TNF 24487321 1959829 Positive_regulation CHUK TNF 24487321 1959853 Positive_regulation CHUK TNF 24487321 1959857 Positive_regulation CHUK TNF 24516376 2299608 Positive_regulation CHUK TNF 24911653 152853 Positive_regulation CHUK TNF 25134539 1883931 Positive_regulation CHUK TNF 25152696 1628008 Positive_regulation CHUK TNF 25229347 3007953 Positive_regulation CHUK TNF 25427002 3030381 Positive_regulation CHUK TNF 25530974 1496787 Positive_regulation CHUK TNF 25553117 3177737 Positive_regulation CHUK TNFSF10 22048166 553353 Positive_regulation CHUK TNFSF10 22672528 482520 Positive_regulation CIB1 EPHB2 23237773 2181997 Positive_regulation CIB1 FOXO1 21209944 2492507 Positive_regulation CIB1 FOXO1 21957439 2557169 Positive_regulation CIB1 FOXO1 24741631 1621412 Positive_regulation CIB1 IFI27 18477650 505690 Positive_regulation CIB1 TNF 23263670 1100098 Positive_regulation CISH CCND1 21244661 1007687 Positive_regulation CISH CD14 20011115 3045899 Positive_regulation CISH CD14 20011115 3045944 Positive_regulation CISH EPHB2 23178880 1928841 Positive_regulation CISH F2R 22731117 1663846 Positive_regulation CISH GPR115 19047197 1682414 Positive_regulation CISH GPR132 19047197 1682403 Positive_regulation CISH GPR87 19047197 1682483 Positive_regulation CISH JAG1 21124801 2484134 Positive_regulation CISH PCDH19 21115806 1383064 Positive_regulation CISH TLR7 22132325 1686772 Positive_regulation CISH TNF 21437087 731228 Positive_regulation CKAP2L TNF 24141950 1991011 Positive_regulation CKAP4 CDKN1C 19221586 2405775 Positive_regulation CKAP4 FOXO1 23906066 700758 Positive_regulation CKAP4 TP63 23420876 1570859 Positive_regulation CKAP4 TP63 24376853 2902498 Positive_regulation CKAP5 NES 15251038 277789 Positive_regulation CKS1B TNF 23255047 605220 Positive_regulation CLASP1 NES 15251038 277768 Positive_regulation CLDN1 TNF 20937153 257592 Positive_regulation CLDN1 TNF 21853060 2542973 Positive_regulation CLDN1 TNF 23082119 2705244 Positive_regulation CLDN1 TNF 25268969 3011817 Positive_regulation CLDN1 TP63 18648642 2393831 Positive_regulation CLDN1 TP63 18648642 2393833 Positive_regulation CLDN10 BMP1 23675417 2792621 Positive_regulation CLDN10 BMP10 23675417 2792629 Positive_regulation CLDN10 BMP15 23675417 2792622 Positive_regulation CLDN10 BMP2 23675417 2792623 Positive_regulation CLDN10 BMP3 23675417 2792624 Positive_regulation CLDN10 BMP4 23675417 2792625 Positive_regulation CLDN10 BMP5 23675417 2792626 Positive_regulation CLDN10 BMP6 23675417 2792627 Positive_regulation CLDN10 BMP7 23675417 2792628 Positive_regulation CLDN10 CASP1 22361748 554554 Positive_regulation CLDN10 CASP10 22361748 554555 Positive_regulation CLDN10 CASP12 22361748 554565 Positive_regulation CLDN10 CASP14 22361748 554556 Positive_regulation CLDN10 CASP16 22361748 554566 Positive_regulation CLDN10 CASP2 22361748 554557 Positive_regulation CLDN10 CASP3 22361748 554558 Positive_regulation CLDN10 CASP4 22361748 554559 Positive_regulation CLDN10 CASP5 22361748 554560 Positive_regulation CLDN10 CASP6 22361748 554561 Positive_regulation CLDN10 CASP7 22361748 554562 Positive_regulation CLDN10 CASP8 22361748 554563 Positive_regulation CLDN10 CASP9 22361748 554564 Positive_regulation CLDN10 ESRRG 22511979 2619180 Positive_regulation CLDN10 F11R 18039951 1547889 Positive_regulation CLDN10 F11R 18039951 1547890 Positive_regulation CLDN10 F11R 18039951 1547914 Positive_regulation CLDN10 F11R 22371556 1395816 Positive_regulation CLDN10 IL17A 24382972 639445 Positive_regulation CLDN10 IL17A 24886047 2231959 Positive_regulation CLDN10 MARVELD3 20028514 283806 Positive_regulation CLDN10 MYLIP 22511979 2619172 Positive_regulation CLDN10 MYLIP 22511979 2619179 Positive_regulation CLDN10 NQO1 24393524 222559 Positive_regulation CLDN10 OCLN 20375010 1186889 Positive_regulation CLDN10 OCLN 22361748 555023 Positive_regulation CLDN10 OCLN 23924897 1817643 Positive_regulation CLDN10 TJP1 21536752 1386760 Positive_regulation CLDN12 CLDN10 21372174 1788874 Positive_regulation CLDN18 EPHB2 22723883 2654993 Positive_regulation CLDN2 TNF 25031428 1828839 Positive_regulation CLDN4 CLDN10 22361748 554927 Positive_regulation CLDN4 PTGER2 25396731 3026986 Positive_regulation CLDN4 TNF 25096552 2252356 Positive_regulation CLDN5 TNF 20693346 716076 Positive_regulation CLEC1B TNF 23570314 1146278 Positive_regulation CLEC2D TLR7 24352438 1704372 Positive_regulation CLEC2D TLR7 24352438 1704373 Positive_regulation CLEC2D TLR7 24352438 1704402 Positive_regulation CLEC2D TLR7 24352438 1704425 Positive_regulation CLEC2D TLR7 24352438 1704445 Positive_regulation CLEC4A TNF 23656637 1666713 Positive_regulation CLEC4D TNF 22689578 1203823 Positive_regulation CLEC5A TNF 20212065 1557457 Positive_regulation CLEC5A TNF 24465901 2911888 Positive_regulation CLEC7A TNF 12719478 1526933 Positive_regulation CLEC7A TNF 15781585 1535163 Positive_regulation CLEC7A TNF 15998786 1536567 Positive_regulation CLEC7A TNF 19223162 691513 Positive_regulation CLEC7A TNF 25140116 1761040 Positive_regulation CLOCK TNF 24901009 1621714 Positive_regulation CLU AR 25395862 2123724 Positive_regulation CLU CA2 22319472 865870 Positive_regulation CLU CA2 24303140 2251357 Positive_regulation CLU CFTR 18368527 3086850 Positive_regulation CLU CR1 22989354 1665051 Positive_regulation CLU CSE 23155386 2716993 Positive_regulation CLU CSE 23155386 2716994 Positive_regulation CLU DPP10 22195697 1626466 Positive_regulation CLU DPP3 22195697 1626467 Positive_regulation CLU DPP4 22195697 1626468 Positive_regulation CLU DPP6 22195697 1626469 Positive_regulation CLU DPP7 22195697 1626463 Positive_regulation CLU DPP8 22195697 1626464 Positive_regulation CLU DPP9 22195697 1626465 Positive_regulation CLU FOXL2 21464964 2510702 Positive_regulation CLU FOXL2 21464964 2510707 Positive_regulation CLU GARS 23616745 930912 Positive_regulation CLU GAST 23805861 343934 Positive_regulation CLU GCM1 23189038 930859 Positive_regulation CLU GCM1 23189038 930860 Positive_regulation CLU GCM1 23189038 930863 Positive_regulation CLU GCM2 23189038 930861 Positive_regulation CLU GCM2 23189038 930862 Positive_regulation CLU GCM2 23189038 930864 Positive_regulation CLU GPR39 22545109 2623404 Positive_regulation CLU HNF1A 17634137 1645567 Positive_regulation CLU HRAS 24672247 2122900 Positive_regulation CLU HSF1 24156019 492152 Positive_regulation CLU HSF1 25138053 2198204 Positive_regulation CLU HSF1 25503391 1947701 Positive_regulation CLU HSPA5 23457489 2758649 Positive_regulation CLU HSPA5 25392688 490135 Positive_regulation CLU ID1 16677418 459813 Positive_regulation CLU IL6 17634137 1645583 Positive_regulation CLU IL6 21909877 495721 Positive_regulation CLU JUN 7490285 1435070 Positive_regulation CLU KLF4 21559189 1052525 Positive_regulation CLU KNG1 23579955 1105466 Positive_regulation CLU MYBL2 PMC2750202 450212 Positive_regulation CLU MYCN 23362253 1206180 Positive_regulation CLU MYCN 23362253 1206184 Positive_regulation CLU NOTCH1 25452709 939383 Positive_regulation CLU NOTCH2 25452709 939384 Positive_regulation CLU NOTCH3 25452709 939385 Positive_regulation CLU NOTCH4 25452709 939386 Positive_regulation CLU PTTG1 21464964 2510703 Positive_regulation CLU PTTG1 21464964 2510708 Positive_regulation CLU PTTG2 21464964 2510704 Positive_regulation CLU PTTG2 21464964 2510709 Positive_regulation CLU SAA1 22758629 668023 Positive_regulation CLU SAA2 22758629 668024 Positive_regulation CLU SAA4 22758629 668025 Positive_regulation CLU SLC12A2 21284844 1996610 Positive_regulation CLU SLC12A2 21284844 1996612 Positive_regulation CLU SLC12A2 23144843 2714715 Positive_regulation CLU SLC12A2 23144843 2714717 Positive_regulation CLU SLC12A2 24949446 192683 Positive_regulation CLU SLC12A2 25206759 2005884 Positive_regulation CLU SLC12A5 22065950 865859 Positive_regulation CLU SLC12A5 23596389 930884 Positive_regulation CLU SLC12A5 24097188 1963614 Positive_regulation CLU SLC12A5 24567703 868737 Positive_regulation CLU STAT1 18631387 1503197 Positive_regulation CLU TGFB1 20981268 161973 Positive_regulation CLU TLR4 24979331 1483701 Positive_regulation CLU VHL 24599003 1883355 Positive_regulation CLU WNT1 17634137 1645586 Positive_regulation CLU WNT11 17634137 1645587 Positive_regulation CLU WNT16 17634137 1645592 Positive_regulation CLU WNT2 17634137 1645588 Positive_regulation CLU WNT3 17634137 1645589 Positive_regulation CLU WNT4 17634137 1645590 Positive_regulation CLU WNT6 17634137 1645591 Positive_regulation CLU YBX1 24770864 2189490 Positive_regulation CLU YBX1 25503391 1947702 Positive_regulation CMIP TNF 23238132 651889 Positive_regulation CMIP TNF 23238132 651890 Positive_regulation CNGA1 MMP28 22699690 621561 Positive_regulation CNGA1 MMP7 22699690 621576 Positive_regulation CNN1 SPHK1 21629665 2525375 Positive_regulation CNR2 EPHB2 24312195 2888270 Positive_regulation CNTF EDN2 21637858 2526959 Positive_regulation CNTF NGFR 19267906 1655640 Positive_regulation CNTN2 CCND1 20101207 2128731 Positive_regulation CNTN2 CCND1 20101207 2128742 Positive_regulation CNTN2 TNFSF10 17907802 3039885 Positive_regulation CNTRL TP63 18627611 323778 Positive_regulation COA1 ACSS1 24278309 2885755 Positive_regulation COA1 FAS 18509489 3072367 Positive_regulation COA1 FAS 22348016 2596443 Positive_regulation COA1 FAS 24217114 501181 Positive_regulation COA1 FOXO1 23532271 453332 Positive_regulation COA3 ACSS1 24278309 2885757 Positive_regulation COA3 FAS 18509489 3072369 Positive_regulation COA3 FAS 22348016 2596445 Positive_regulation COA3 FAS 24217114 501185 Positive_regulation COA3 FOXO1 23532271 453334 Positive_regulation COA4 ACSS1 24278309 2885756 Positive_regulation COA4 FAS 18509489 3072368 Positive_regulation COA4 FAS 22348016 2596444 Positive_regulation COA4 FAS 24217114 501183 Positive_regulation COA4 FOXO1 23532271 453333 Positive_regulation COA5 ACSS1 24278309 2885758 Positive_regulation COA5 FAS 18509489 3072370 Positive_regulation COA5 FAS 22348016 2596446 Positive_regulation COA5 FAS 24217114 501187 Positive_regulation COA5 FOXO1 23532271 453335 Positive_regulation COA6 ACSS1 24278309 2885754 Positive_regulation COA6 FAS 18509489 3072366 Positive_regulation COA6 FAS 22348016 2596442 Positive_regulation COA6 FAS 24217114 501178 Positive_regulation COA6 FOXO1 23532271 453331 Positive_regulation COG2 PCSK9 20498851 2451198 Positive_regulation COG2 PCSK9 22848640 2669917 Positive_regulation COG2 PCSK9 22998978 1724966 Positive_regulation COG2 PCSK9 24115837 742805 Positive_regulation COG2 PCSK9 25042549 19288 Positive_regulation COG2 PCSK9 25110901 691671 Positive_regulation COG2 PCSK9 25470376 2119145 Positive_regulation COIL LAMB3 8647901 1451703 Positive_regulation COL10A1 CEACAM6 21627827 122590 Positive_regulation COL17A1 AIRE 23781320 787391 Positive_regulation COL17A1 HDAC1 9660880 1468395 Positive_regulation COL17A1 PLEC 9660880 1468396 Positive_regulation COL17A1 SOX9 22761195 2180370 Positive_regulation COL1A1 CAPN8 PMC3329082 3086506 Positive_regulation COL1A1 CTGF 16303051 524653 Positive_regulation COL1A1 CTGF 23663495 128403 Positive_regulation COL1A1 CTGF 24090133 537699 Positive_regulation COL1A1 CTGF 24937684 1127853 Positive_regulation COL1A1 EPHB2 23936252 2829708 Positive_regulation COL1A1 EPHB2 24011378 3114085 Positive_regulation COL1A1 EPHB2 24090133 537633 Positive_regulation COL1A1 F2R 24475094 2914736 Positive_regulation COL1A1 HBEGF 22984591 2689360 Positive_regulation COL1A1 HBEGF 22984591 2689370 Positive_regulation COL1A1 MAP2K6 24011378 3114091 Positive_regulation COL1A1 MAP2K6 24090133 537639 Positive_regulation COL1A1 MMP28 23945134 129010 Positive_regulation COL1A1 MMP7 23945134 129025 Positive_regulation COL1A1 TNF 25457675 805863 Positive_regulation COL1A2 CAPN8 PMC3329082 3086521 Positive_regulation COL1A2 CTGF 16303051 524654 Positive_regulation COL1A2 CTGF 23663495 128404 Positive_regulation COL1A2 CTGF 24090133 537702 Positive_regulation COL1A2 CTGF 24937684 1127854 Positive_regulation COL1A2 EPHB2 23936252 2829711 Positive_regulation COL1A2 EPHB2 24011378 3114093 Positive_regulation COL1A2 EPHB2 24090133 537641 Positive_regulation COL1A2 F2R 24475094 2914737 Positive_regulation COL1A2 HBEGF 22984591 2689361 Positive_regulation COL1A2 HBEGF 22984591 2689372 Positive_regulation COL1A2 ITGAL 25414732 641070 Positive_regulation COL1A2 MAP2K6 24011378 3114099 Positive_regulation COL1A2 MAP2K6 24090133 537647 Positive_regulation COL1A2 MMP28 23945134 129032 Positive_regulation COL1A2 MMP7 23945134 129047 Positive_regulation COL1A2 MMP7 24273653 2251292 Positive_regulation COL1A2 MMP7 24273653 2251299 Positive_regulation COL1A2 MMP7 24273653 2251300 Positive_regulation COL1A2 MMP7 24273653 2251303 Positive_regulation COL1A2 MMP7 24273653 2251309 Positive_regulation COL1A2 TNF 25457675 805864 Positive_regulation COL2A1 ADAMTS1 25003544 454078 Positive_regulation COL2A1 CEACAM6 21627827 122591 Positive_regulation COL2A1 CTGF 19144181 112498 Positive_regulation COL2A1 CTGF 20205862 397081 Positive_regulation COL2A1 CTGF 23555635 2774671 Positive_regulation COL2A1 CTGF 23951098 2833419 Positive_regulation COL2A1 MMP28 20021645 396989 Positive_regulation COL2A1 MMP28 21539724 122428 Positive_regulation COL2A1 MMP7 20021645 397004 Positive_regulation COL2A1 MMP7 21539724 122443 Positive_regulation COL2A1 TNF 15642133 102077 Positive_regulation COL3A1 ADAMTS1 23012495 178266 Positive_regulation COL3A1 MMP7 24273653 2251293 Positive_regulation COL4A1 PLAT 24026771 1890412 Positive_regulation COL4A2 PLAT 24026771 1890413 Positive_regulation COL4A3 PLAT 24026771 1890414 Positive_regulation COL4A3BP TNF 22419908 951350 Positive_regulation COL4A4 PLAT 24026771 1890415 Positive_regulation COL4A5 PLAT 24026771 1890416 Positive_regulation COL4A6 PLAT 24026771 1890417 Positive_regulation COMP TNF 19226472 112894 Positive_regulation COMP TNF 22264230 124592 Positive_regulation COP NES 20843328 1858935 Positive_regulation COPS5 S100A7 20955608 585858 Positive_regulation CORO2A PGC 23304112 3076118 Positive_regulation COX4I1 PGC 23285128 2732596 Positive_regulation COX5A PGC 19435887 1165966 Positive_regulation COX5A PGC 19435887 1165977 Positive_regulation COX7A1 PGC 23093952 3076067 Positive_regulation COX7A2L KANK4 25203404 3006364 Positive_regulation CP TNF 2439635 1574442 Positive_regulation CPA4 NEUROG3 24843545 1493536 Positive_regulation CPA4 PTF1A 24843545 1493537 Positive_regulation CPB1 TNF 24386164 2902929 Positive_regulation CPB2 TGM2 20421939 3046627 Positive_regulation CPB2 TNF 24386164 2902930 Positive_regulation CPE EPHB2 23977080 2838324 Positive_regulation CPE FOXO1 19767734 1960798 Positive_regulation CPLX1 PGC 25610371 872913 Positive_regulation CPOX IL1B 11132768 1737184 Positive_regulation CPOX IL1B 11132768 1737185 Positive_regulation CPOX IL1B 11132768 1737189 Positive_regulation CPOX IL1B 11132768 1737220 Positive_regulation CPOX IL1B PMC3007808 1702506 Positive_regulation CPOX PGC 23226091 2244447 Positive_regulation CPOX TNF 18955282 811118 Positive_regulation CPOX TNF 21955617 124052 Positive_regulation CPOX TNF 24379887 825004 Positive_regulation CPP EPHB2 19956756 2432680 Positive_regulation CPP EPHB2 24653683 921987 Positive_regulation CPP MAP2K6 24653683 921993 Positive_regulation CPP MMP28 25157203 1605598 Positive_regulation CPP MMP28 25157203 1605659 Positive_regulation CPP MMP7 25157203 1605613 Positive_regulation CPP MMP7 25157203 1605674 Positive_regulation CPP TNF 23577176 2778502 Positive_regulation CPP TNF 23577176 2778510 Positive_regulation CPT1A FAS 16969344 428154 Positive_regulation CPT1A FAS 24379011 2118401 Positive_regulation CPT1A FOXA1 22187655 1638865 Positive_regulation CPT1A FOXO1 22533991 264523 Positive_regulation CPT1A FOXO1 22533991 264524 Positive_regulation CPT1A FOXO1 22533991 264525 Positive_regulation CPT1A FOXO1 22533991 264556 Positive_regulation CPT1A PGC 23355796 1061211 Positive_regulation CPT1A PGC 25197313 826824 Positive_regulation CPT1B PGC 19435887 1165960 Positive_regulation CPT1B PGC 19435887 1165968 Positive_regulation CPT1B PGC 19435887 1165972 Positive_regulation CPT1B PGC 20682693 715838 Positive_regulation CPT1B PGC 21904680 154549 Positive_regulation CPT1B PGC 21904680 154553 Positive_regulation CPT2 PGC 23093952 3076013 Positive_regulation CPT2 PGC 23093952 3076033 Positive_regulation CR1 CLU 22989354 1665052 Positive_regulation CR1 TNF 21867543 290955 Positive_regulation CRAT TMEM100 10508860 1251154 Positive_regulation CRAT TMEM156 10508860 1251172 Positive_regulation CRAT TMEM211 10508860 1251252 Positive_regulation CRAT TMEM213 10508860 1251189 Positive_regulation CRAT TNF 2109037 1561573 Positive_regulation CRAT TNF 2193097 1565446 Positive_regulation CRAT TNF 2193097 1565449 Positive_regulation CREB1 ARSA 20640495 511691 Positive_regulation CREB1 CTGF 23902294 344709 Positive_regulation CREB1 CYP24A1 19015318 1361180 Positive_regulation CREB1 EPHB2 12969508 382312 Positive_regulation CREB1 EPHB2 18036509 153755 Positive_regulation CREB1 EPHB2 18487450 705990 Positive_regulation CREB1 EPHB2 19390691 2415413 Positive_regulation CREB1 EPHB2 19419557 1891242 Positive_regulation CREB1 EPHB2 19602257 385620 Positive_regulation CREB1 EPHB2 19917132 385860 Positive_regulation CREB1 EPHB2 19956756 2432686 Positive_regulation CREB1 EPHB2 20162032 927765 Positive_regulation CREB1 EPHB2 21151573 2485188 Positive_regulation CREB1 EPHB2 21151573 2485195 Positive_regulation CREB1 EPHB2 21912749 2002255 Positive_regulation CREB1 EPHB2 21994688 3219626 Positive_regulation CREB1 EPHB2 22022544 2563791 Positive_regulation CREB1 EPHB2 22028687 860528 Positive_regulation CREB1 EPHB2 22028687 860583 Positive_regulation CREB1 EPHB2 22116789 1987 Positive_regulation CREB1 EPHB2 22701758 2224470 Positive_regulation CREB1 EPHB2 22754300 1095925 Positive_regulation CREB1 EPHB2 22916239 2680319 Positive_regulation CREB1 EPHB2 22916239 2680357 Positive_regulation CREB1 EPHB2 22931352 1231156 Positive_regulation CREB1 EPHB2 23843874 821197 Positive_regulation CREB1 EPHB2 24129178 1113346 Positive_regulation CREB1 EPHB2 24312401 2889187 Positive_regulation CREB1 EPHB2 24336080 570431 Positive_regulation CREB1 EPHB2 24498195 2918902 Positive_regulation CREB1 EPHB2 24695790 2948420 Positive_regulation CREB1 EPHB2 24846311 2972226 Positive_regulation CREB1 EPHB2 25294025 349132 Positive_regulation CREB1 EPHB2 25302800 3014660 Positive_regulation CREB1 EPHB2 25365078 2206680 Positive_regulation CREB1 GLP1R 21744074 733470 Positive_regulation CREB1 GLP1R 23188390 733682 Positive_regulation CREB1 GPR115 24238363 221211 Positive_regulation CREB1 GPR132 24238363 221200 Positive_regulation CREB1 GPR87 24238363 221280 Positive_regulation CREB1 MAP2K6 16792806 383901 Positive_regulation CREB1 MAP2K6 19390691 2415419 Positive_regulation CREB1 MAP2K6 19419557 1891295 Positive_regulation CREB1 MAP2K6 19543489 1711663 Positive_regulation CREB1 MAP2K6 22022544 2563797 Positive_regulation CREB1 MAP2K6 23865384 388493 Positive_regulation CREB1 MAP2K6 23865384 388558 Positive_regulation CREB1 MAP2K6 24129178 1113355 Positive_regulation CREB1 MAP2K6 25294025 349138 Positive_regulation CREB1 MAP2K6 25302800 3014674 Positive_regulation CREB1 MAP2K6 25365078 2206686 Positive_regulation CREB1 PGC 18487450 706060 Positive_regulation CREB1 PGC 22035495 520087 Positive_regulation CREB1 PGC 22540007 2623103 Positive_regulation CREB1 PGC 22888430 1155583 Positive_regulation CREB1 PGC 22919323 3153781 Positive_regulation CREB1 PTGER2 25327961 216586 Positive_regulation CREB1 RASD1 21915321 2553240 Positive_regulation CREB1 TLR7 23800014 1232302 Positive_regulation CREB1 TLR7 24489729 2916135 Positive_regulation CREB1 TLR7 25351958 153463 Positive_regulation CREB1 TNF 22919361 3153835 Positive_regulation CREB1 TNF 24386331 2903653 Positive_regulation CREB1 TNF 24603712 2931976 Positive_regulation CREB1 TNF 24603712 2931981 Positive_regulation CREB1 UCA1 23725405 1618228 Positive_regulation CREB1 UCA1 24648007 2171565 Positive_regulation CREB3 ARSA 20640495 511694 Positive_regulation CREB3 CTGF 23902294 344710 Positive_regulation CREB3 CYP24A1 19015318 1361182 Positive_regulation CREB3 EPHB2 12969508 382313 Positive_regulation CREB3 EPHB2 18036509 153756 Positive_regulation CREB3 EPHB2 18487450 706004 Positive_regulation CREB3 EPHB2 19390691 2415421 Positive_regulation CREB3 EPHB2 19419557 1891243 Positive_regulation CREB3 EPHB2 19602257 385622 Positive_regulation CREB3 EPHB2 19917132 385862 Positive_regulation CREB3 EPHB2 19956756 2432687 Positive_regulation CREB3 EPHB2 20162032 927766 Positive_regulation CREB3 EPHB2 21151573 2485189 Positive_regulation CREB3 EPHB2 21912749 2002269 Positive_regulation CREB3 EPHB2 21994688 3219627 Positive_regulation CREB3 EPHB2 22022544 2563799 Positive_regulation CREB3 EPHB2 22028687 860535 Positive_regulation CREB3 EPHB2 22028687 860592 Positive_regulation CREB3 EPHB2 22116789 1997 Positive_regulation CREB3 EPHB2 22701758 2224471 Positive_regulation CREB3 EPHB2 22754300 1095927 Positive_regulation CREB3 EPHB2 22916239 2680337 Positive_regulation CREB3 EPHB2 22916239 2680358 Positive_regulation CREB3 EPHB2 22931352 1231157 Positive_regulation CREB3 EPHB2 23843874 821198 Positive_regulation CREB3 EPHB2 24129178 1113359 Positive_regulation CREB3 EPHB2 24336080 570432 Positive_regulation CREB3 EPHB2 24498195 2918903 Positive_regulation CREB3 EPHB2 24695790 2948421 Positive_regulation CREB3 EPHB2 24846311 2972227 Positive_regulation CREB3 EPHB2 25294025 349141 Positive_regulation CREB3 EPHB2 25302800 3014661 Positive_regulation CREB3 EPHB2 25365078 2206688 Positive_regulation CREB3 GLP1R 21744074 733471 Positive_regulation CREB3 GLP1R 23188390 733684 Positive_regulation CREB3 GPR115 24238363 221304 Positive_regulation CREB3 GPR132 24238363 221293 Positive_regulation CREB3 GPR87 24238363 221373 Positive_regulation CREB3 MAP2K6 16792806 383909 Positive_regulation CREB3 MAP2K6 19390691 2415427 Positive_regulation CREB3 MAP2K6 19419557 1891302 Positive_regulation CREB3 MAP2K6 19543489 1711683 Positive_regulation CREB3 MAP2K6 22022544 2563805 Positive_regulation CREB3 MAP2K6 23865384 388500 Positive_regulation CREB3 MAP2K6 23865384 388577 Positive_regulation CREB3 MAP2K6 24129178 1113368 Positive_regulation CREB3 MAP2K6 25294025 349147 Positive_regulation CREB3 MAP2K6 25302800 3014681 Positive_regulation CREB3 MAP2K6 25365078 2206694 Positive_regulation CREB3 PGC 18487450 706061 Positive_regulation CREB3 PGC 22035495 520088 Positive_regulation CREB3 PGC 22540007 2623104 Positive_regulation CREB3 PGC 22888430 1155584 Positive_regulation CREB3 PGC 22919323 3153782 Positive_regulation CREB3 PTGER2 25327961 216587 Positive_regulation CREB3 RASD1 21915321 2553241 Positive_regulation CREB3 TLR7 23800014 1232312 Positive_regulation CREB3 TLR7 24489729 2916145 Positive_regulation CREB3 TLR7 25351958 153475 Positive_regulation CREB3 TNF 22919361 3153836 Positive_regulation CREB3 TNF 24386331 2903654 Positive_regulation CREB3 TNF 24603712 2931977 Positive_regulation CREB3 TNF 24603712 2931982 Positive_regulation CREB3 UCA1 23725405 1618229 Positive_regulation CREB3 UCA1 24648007 2171566 Positive_regulation CREB3L2 HRAS 21711675 519083 Positive_regulation CREB3L2 KRAS 21711675 519084 Positive_regulation CREB3L2 MAPK1 21711675 519085 Positive_regulation CREB3L2 MAPK10 21711675 519086 Positive_regulation CREB3L2 MAPK11 21711675 519087 Positive_regulation CREB3L2 MAPK12 21711675 519088 Positive_regulation CREB3L2 MAPK13 21711675 519089 Positive_regulation CREB3L2 MAPK14 21711675 519090 Positive_regulation CREB3L2 MAPK15 21711675 519082 Positive_regulation CREB3L2 MAPK3 21711675 519091 Positive_regulation CREB3L2 MAPK4 21711675 519092 Positive_regulation CREB3L2 MAPK6 21711675 519093 Positive_regulation CREB3L2 MAPK7 21711675 519094 Positive_regulation CREB3L2 MAPK8 21711675 519095 Positive_regulation CREB3L2 MAPK9 21711675 519096 Positive_regulation CREB3L2 NRAS 21711675 519097 Positive_regulation CREB3L2 SOX9 24711445 1209099 Positive_regulation CREB3L2 SOX9 24711445 1209100 Positive_regulation CREB3L2 SOX9 24711445 1209106 Positive_regulation CREB3L2 SOX9 24711445 1209107 Positive_regulation CREB3L2 SOX9 24711445 1209108 Positive_regulation CREB3L2 SOX9 24711445 1209109 Positive_regulation CREB3L2 SOX9 24711445 1209113 Positive_regulation CREB3L2 SOX9 24711445 1209120 Positive_regulation CREB3L2 SOX9 24711445 1209121 Positive_regulation CREB3L2 SOX9 24711445 1209123 Positive_regulation CREB3L2 SOX9 24711445 1209127 Positive_regulation CREB3L2 SOX9 24711445 1209137 Positive_regulation CREB5 ARSA 20640495 511688 Positive_regulation CREB5 CTGF 23902294 344708 Positive_regulation CREB5 CYP24A1 19015318 1361178 Positive_regulation CREB5 EPHB2 12969508 382311 Positive_regulation CREB5 EPHB2 18036509 153754 Positive_regulation CREB5 EPHB2 18487450 705976 Positive_regulation CREB5 EPHB2 19390691 2415405 Positive_regulation CREB5 EPHB2 19419557 1891241 Positive_regulation CREB5 EPHB2 19602257 385618 Positive_regulation CREB5 EPHB2 19917132 385858 Positive_regulation CREB5 EPHB2 19956756 2432685 Positive_regulation CREB5 EPHB2 20162032 927764 Positive_regulation CREB5 EPHB2 21151573 2485187 Positive_regulation CREB5 EPHB2 21912749 2002241 Positive_regulation CREB5 EPHB2 21994688 3219625 Positive_regulation CREB5 EPHB2 22022544 2563783 Positive_regulation CREB5 EPHB2 22028687 860521 Positive_regulation CREB5 EPHB2 22028687 860574 Positive_regulation CREB5 EPHB2 22116789 1977 Positive_regulation CREB5 EPHB2 22701758 2224469 Positive_regulation CREB5 EPHB2 22754300 1095923 Positive_regulation CREB5 EPHB2 22916239 2680301 Positive_regulation CREB5 EPHB2 22916239 2680356 Positive_regulation CREB5 EPHB2 22931352 1231155 Positive_regulation CREB5 EPHB2 23843874 821196 Positive_regulation CREB5 EPHB2 24129178 1113333 Positive_regulation CREB5 EPHB2 24336080 570428 Positive_regulation CREB5 EPHB2 24498195 2918900 Positive_regulation CREB5 EPHB2 24695790 2948419 Positive_regulation CREB5 EPHB2 24846311 2972225 Positive_regulation CREB5 EPHB2 25294025 349123 Positive_regulation CREB5 EPHB2 25302800 3014659 Positive_regulation CREB5 EPHB2 25365078 2206672 Positive_regulation CREB5 GLP1R 21744074 733469 Positive_regulation CREB5 GLP1R 23188390 733680 Positive_regulation CREB5 GPR115 24238363 221118 Positive_regulation CREB5 GPR132 24238363 221107 Positive_regulation CREB5 GPR87 24238363 221187 Positive_regulation CREB5 MAP2K6 16792806 383893 Positive_regulation CREB5 MAP2K6 19390691 2415411 Positive_regulation CREB5 MAP2K6 19419557 1891288 Positive_regulation CREB5 MAP2K6 19543489 1711643 Positive_regulation CREB5 MAP2K6 22022544 2563789 Positive_regulation CREB5 MAP2K6 23865384 388486 Positive_regulation CREB5 MAP2K6 23865384 388539 Positive_regulation CREB5 MAP2K6 24129178 1113342 Positive_regulation CREB5 MAP2K6 25294025 349129 Positive_regulation CREB5 MAP2K6 25302800 3014667 Positive_regulation CREB5 MAP2K6 25365078 2206678 Positive_regulation CREB5 PGC 18487450 706059 Positive_regulation CREB5 PGC 22035495 520086 Positive_regulation CREB5 PGC 22540007 2623102 Positive_regulation CREB5 PGC 22888430 1155582 Positive_regulation CREB5 PGC 22919323 3153780 Positive_regulation CREB5 PTGER2 25327961 216585 Positive_regulation CREB5 RASD1 21915321 2553239 Positive_regulation CREB5 TLR7 23800014 1232292 Positive_regulation CREB5 TLR7 24489729 2916125 Positive_regulation CREB5 TLR7 25351958 153451 Positive_regulation CREB5 TNF 22919361 3153834 Positive_regulation CREB5 TNF 24386331 2903652 Positive_regulation CREB5 TNF 24603712 2931975 Positive_regulation CREB5 TNF 24603712 2931980 Positive_regulation CREB5 UCA1 23725405 1618227 Positive_regulation CREB5 UCA1 24648007 2171564 Positive_regulation CREBBP EPHB2 21572418 1925865 Positive_regulation CREBBP EPHB2 21860657 813144 Positive_regulation CREG1 EPHB2 24018888 1112416 Positive_regulation CREG1 EPHB2 24018888 1112417 Positive_regulation CREG1 EPHB2 24018888 1112418 Positive_regulation CRH EPHB2 24653683 921995 Positive_regulation CRH GPR115 22832404 3189051 Positive_regulation CRH GPR132 22832404 3189040 Positive_regulation CRH GPR87 22832404 3189121 Positive_regulation CRH NES 19455148 1900383 Positive_regulation CRH TNF 15025773 658514 Positive_regulation CRH TNF 18297215 652397 Positive_regulation CRH TNF 22028729 633465 Positive_regulation CRH TNF 2205054 3228963 Positive_regulation CRH TNF 22768175 2659982 Positive_regulation CRHR1 ENPP1 23168575 2235794 Positive_regulation CRK ANGPT1 24308939 1158437 Positive_regulation CRK CAPN8 21863137 933546 Positive_regulation CRK CCND1 22404972 528347 Positive_regulation CRK CD14 20011115 3045926 Positive_regulation CRK CHI3L1 19930630 507963 Positive_regulation CRK CTGF 19852794 1227776 Positive_regulation CRK CTGF 23227240 2725727 Positive_regulation CRK EPHB2 10477763 1249213 Positive_regulation CRK EPHB2 21488184 3232763 Positive_regulation CRK EPHB2 23320613 472755 Positive_regulation CRK EPHB2 23638878 1868107 Positive_regulation CRK EPHB2 24058693 2848578 Positive_regulation CRK EPHB2 24146543 1916414 Positive_regulation CRK FAS 9362518 1464797 Positive_regulation CRK FAS 9362518 1464798 Positive_regulation CRK FBXO32 23046544 3161176 Positive_regulation CRK IL1B 24049554 137221 Positive_regulation CRK MAP2K6 17576777 1546407 Positive_regulation CRK MAP2K6 20550965 158601 Positive_regulation CRK MAP2K6 22415879 721969 Positive_regulation CRK MAP2K6 22454693 814034 Positive_regulation CRK MAP2K6 23046544 3161177 Positive_regulation CRK MAP2K6 24553827 85139 Positive_regulation CRK MAP2K6 24771982 1758270 Positive_regulation CRK MAP2K6 9314533 1463470 Positive_regulation CRK MIP 19781090 1625705 Positive_regulation CRK MUC16 23694968 3135898 Positive_regulation CRK SPHK1 20498849 2451192 Positive_regulation CRK TLR7 18461564 807345 Positive_regulation CRK TLR7 21064192 775660 Positive_regulation CRK TLR7 22091401 1831076 Positive_regulation CRK TNF 17342245 810709 Positive_regulation CRK TNF 18591389 706343 Positive_regulation CRK TNF 19707336 175485 Positive_regulation CRK TNF 19723340 1227356 Positive_regulation CRK TNF 20070884 1852892 Positive_regulation CRK TNF 20070884 1852904 Positive_regulation CRK TNF 20070884 1852905 Positive_regulation CRK TNF 20529221 34771 Positive_regulation CRK TNF 21264230 2494874 Positive_regulation CRK TNF 21390243 1049711 Positive_regulation CRK TNF 21572963 2520311 Positive_regulation CRK TNF 22158049 2144818 Positive_regulation CRK TNF 22158049 2144849 Positive_regulation CRK TNF 22802702 1714251 Positive_regulation CRK TNF 22901757 126647 Positive_regulation CRK TNF 23152905 2716801 Positive_regulation CRK TNF 23389627 1811772 Positive_regulation CRK TNF 23536830 2773086 Positive_regulation CRK TNF 23603982 17482 Positive_regulation CRK TNF 23691498 181463 Positive_regulation CRK TNF 24049554 137220 Positive_regulation CRK TNF 24086560 2854639 Positive_regulation CRK TNF 24386331 2903610 Positive_regulation CRK TNF 24460683 240483 Positive_regulation CRK TNF 24487321 1959830 Positive_regulation CRK TNF 24487321 1959854 Positive_regulation CRK TNF 24826069 1917010 Positive_regulation CRK TNF 25239871 32265 Positive_regulation CRK TNFSF10 22462553 1230482 Positive_regulation CRK TNFSF10 22462553 1230501 Positive_regulation CRK TNS1 18776587 736219 Positive_regulation CROT EPHB2 21505228 2175881 Positive_regulation CROT FOXA1 22238690 2587075 Positive_regulation CROT MAP2K6 21505228 2175887 Positive_regulation CRP IL1B 24009648 2214725 Positive_regulation CRP LBP 24743550 3066761 Positive_regulation CRP TNF 16669999 3107223 Positive_regulation CRP TNF 17704137 2028985 Positive_regulation CRP TNF 17704137 2028986 Positive_regulation CRP TNF 17704137 2028991 Positive_regulation CRP TNF 17704137 2028992 Positive_regulation CRP TNF 17704137 2028993 Positive_regulation CRP TNF 17704137 2028995 Positive_regulation CRP TNF 17704137 2028996 Positive_regulation CRP TNF 17704137 2028997 Positive_regulation CRP TNF 17704137 2028998 Positive_regulation CRP TNF 18787704 2396367 Positive_regulation CRP TNF 22347541 1675377 Positive_regulation CRP TNF 23299528 439760 Positive_regulation CRP TNF 24363550 649818 Positive_regulation CRP TNF 24744504 1758196 Positive_regulation CRP TNF 24877058 191918 Positive_regulation CRP TNF 24957270 1702188 Positive_regulation CRP TNF 25105150 1496620 Positive_regulation CRP TNF 25109718 1045934 Positive_regulation CRP TNF PMC3273226 99574 Positive_regulation CRS EPHB2 22048896 3170174 Positive_regulation CRS EPHB2 23346300 2115252 Positive_regulation CRTC2 IFI27 24759584 137088 Positive_regulation CRTC2 PGC 24529027 3216221 Positive_regulation CRTC2 PGC 24529027 3216224 Positive_regulation CRTC2 PGC 24529027 3216225 Positive_regulation CRX CD14 23166489 3060016 Positive_regulation CRY2 EPHB2 24667437 2938712 Positive_regulation CRY2 TNF 24901009 1621708 Positive_regulation CRYGEP TNF 24064574 2118082 Positive_regulation CRYGEP TNFSF10 22194670 3152399 Positive_regulation CRYGEP ZFP57 23569325 1571491 Positive_regulation CS PGC 25136584 197221 Positive_regulation CSDE1 LAMB3 22160594 1798613 Positive_regulation CSDE1 TNF 23688423 314165 Positive_regulation CSDE1 TNF 9382882 1602111 Positive_regulation CSE CCND1 20429916 3110326 Positive_regulation CSE CCND1 20429916 3110351 Positive_regulation CSE EPHB2 24386310 2903429 Positive_regulation CSE EPHB2 25165413 1761846 Positive_regulation CSE SRGN 23945069 1481407 Positive_regulation CSE TNF 19293939 2408188 Positive_regulation CSE TNF 19515231 3109650 Positive_regulation CSE TNF 21738617 2532823 Positive_regulation CSF1 ABCG2 25295160 3208143 Positive_regulation CSF1 CD14 24083466 356490 Positive_regulation CSF1 EPHB2 18852899 2397580 Positive_regulation CSF1 EPHB2 18852899 2397668 Positive_regulation CSF1 EPHB2 22028782 2564169 Positive_regulation CSF1 EPHB2 22873932 532953 Positive_regulation CSF1 EPHB2 23752925 611264 Positive_regulation CSF1 F3 19773616 736322 Positive_regulation CSF1 LINC00284 25431574 917205 Positive_regulation CSF1 LINC00341 25431574 917165 Positive_regulation CSF1 MAP2K6 21738673 2533226 Positive_regulation CSF1 MAP2K6 22028782 2564175 Positive_regulation CSF1 MAP2K6 22873932 532959 Positive_regulation CSF1 NEDD9 23180782 2082329 Positive_regulation CSF1 TNF 11953891 421553 Positive_regulation CSF1 TNF 12745546 1738341 Positive_regulation CSF1 TNF 18472951 1743307 Positive_regulation CSF1 TNF 1911209 431530 Positive_regulation CSF1 TNF 1911209 431569 Positive_regulation CSF1 TNF 20212065 1557466 Positive_regulation CSF1 TNF 21266043 286093 Positive_regulation CSF1 TNF 22563430 2626507 Positive_regulation CSF1 TNF 23029275 2695925 Positive_regulation CSF1 TNF 23052657 2235658 Positive_regulation CSF1 TNF 23110133 2706585 Positive_regulation CSF1 TNF 23762085 637604 Positive_regulation CSF1 TNF 23762085 637606 Positive_regulation CSF1 TNF 23762085 637607 Positive_regulation CSF1 TNF 23762133 819966 Positive_regulation CSF1 TNF 23935927 2828475 Positive_regulation CSF1 TNF 24019592 3079929 Positive_regulation CSF1 TNF 24339952 2894369 Positive_regulation CSF1 TNF 24339952 2894370 Positive_regulation CSF1 TNF 24339952 2894374 Positive_regulation CSF1 TNF 24339952 2894376 Positive_regulation CSF1 TNF 24339952 2894382 Positive_regulation CSF1 TNF 24339952 2894386 Positive_regulation CSF1 TNF 24470972 1049869 Positive_regulation CSF1 TNF 2509625 1577154 Positive_regulation CSF1 TNF 8381656 444838 Positive_regulation CSF1R CD14 22879381 2080322 Positive_regulation CSF2 CA12 24391755 2904421 Positive_regulation CSF2 EPHB2 21682898 123010 Positive_regulation CSF2 EPHB2 23752925 611265 Positive_regulation CSF2 EPHB2 25032960 2990192 Positive_regulation CSF2 F2R 21464892 2510282 Positive_regulation CSF2 HBEGF 20946648 1859853 Positive_regulation CSF2 HBEGF 20946648 1859859 Positive_regulation CSF2 HBEGF 20946648 1859860 Positive_regulation CSF2 HBEGF 20946648 1859863 Positive_regulation CSF2 HBEGF 20946648 1859864 Positive_regulation CSF2 HBEGF 20946648 1859873 Positive_regulation CSF2 HBEGF 23888518 3185319 Positive_regulation CSF2 IL1B 11132773 1737244 Positive_regulation CSF2 IL1B 11132773 1737245 Positive_regulation CSF2 IL1B 11132773 1737246 Positive_regulation CSF2 IL1B 11132773 1737264 Positive_regulation CSF2 IL1B 11132773 1737265 Positive_regulation CSF2 IL1B 11132773 1737405 Positive_regulation CSF2 IL1B 9400742 797436 Positive_regulation CSF2 ITGB2 1717633 1543719 Positive_regulation CSF2 MIP 2478652 1576109 Positive_regulation CSF2 MMP7 25107295 647572 Positive_regulation CSF2 PLAU 15559369 630332 Positive_regulation CSF2 TCN1 22750193 1492586 Positive_regulation CSF2 TLR7 19426550 282606 Positive_regulation CSF2 TLR7 19426550 282659 Positive_regulation CSF2 TLR7 19426550 282675 Positive_regulation CSF2 TLR7 20821041 1491388 Positive_regulation CSF2 TLR7 24155889 2871013 Positive_regulation CSF2 TLR7 24155889 2871014 Positive_regulation CSF2 TLR7 25071732 926940 Positive_regulation CSF2 TLR7 25071732 926941 Positive_regulation CSF2 TLR7 25071732 927115 Positive_regulation CSF2 TNF 10385526 1247197 Positive_regulation CSF2 TNF 10385526 1247207 Positive_regulation CSF2 TNF 10385526 1247208 Positive_regulation CSF2 TNF 11132773 1737241 Positive_regulation CSF2 TNF 11132773 1737242 Positive_regulation CSF2 TNF 11132773 1737243 Positive_regulation CSF2 TNF 11132773 1737262 Positive_regulation CSF2 TNF 11132773 1737263 Positive_regulation CSF2 TNF 11132773 1737404 Positive_regulation CSF2 TNF 1328463 1528407 Positive_regulation CSF2 TNF 1328463 1528411 Positive_regulation CSF2 TNF 1328463 1528412 Positive_regulation CSF2 TNF 1328463 1528413 Positive_regulation CSF2 TNF 1328463 1528414 Positive_regulation CSF2 TNF 1328463 1528416 Positive_regulation CSF2 TNF 1328463 1528418 Positive_regulation CSF2 TNF 1375270 1528752 Positive_regulation CSF2 TNF 1375270 1528753 Positive_regulation CSF2 TNF 1375270 1528754 Positive_regulation CSF2 TNF 1375270 1528755 Positive_regulation CSF2 TNF 15857511 648854 Positive_regulation CSF2 TNF 15857511 648868 Positive_regulation CSF2 TNF 15857511 648869 Positive_regulation CSF2 TNF 1643416 702435 Positive_regulation CSF2 TNF 18472926 1743194 Positive_regulation CSF2 TNF 18472951 1743308 Positive_regulation CSF2 TNF 18475466 1743839 Positive_regulation CSF2 TNF 19118493 651000 Positive_regulation CSF2 TNF 19686583 116574 Positive_regulation CSF2 TNF 1972179 1556150 Positive_regulation CSF2 TNF 19788749 3110061 Positive_regulation CSF2 TNF 2007858 1557296 Positive_regulation CSF2 TNF 2022925 1557539 Positive_regulation CSF2 TNF 21079906 1644330 Positive_regulation CSF2 TNF 21106069 1621035 Positive_regulation CSF2 TNF 2183871 437503 Positive_regulation CSF2 TNF 21861862 123876 Positive_regulation CSF2 TNF 22615502 1044046 Positive_regulation CSF2 TNF 23352035 1506684 Positive_regulation CSF2 TNF 23554905 2773629 Positive_regulation CSF2 TNF 23935927 2828481 Positive_regulation CSF2 TNF 24311895 1755541 Positive_regulation CSF2 TNF 24446489 1574665 Positive_regulation CSF2 TNF 24446489 1574669 Positive_regulation CSF2 TNF 24446489 1574672 Positive_regulation CSF2 TNF 24446489 1574683 Positive_regulation CSF2 TNF 24453421 1756850 Positive_regulation CSF2 TNF 24479486 1667598 Positive_regulation CSF2 TNF 24489443 1757415 Positive_regulation CSF2 TNF 24587316 2929404 Positive_regulation CSF2 TNF 24995121 652240 Positive_regulation CSF2 TNF 25104881 1760300 Positive_regulation CSF2 TNF 2538549 1577292 Positive_regulation CSF2 TNF 25506346 921518 Positive_regulation CSF2 TNF 2647480 795283 Positive_regulation CSF2 TNF 2647480 795346 Positive_regulation CSF2 TNF 2659724 1577673 Positive_regulation CSF2 TNF 3049617 1425611 Positive_regulation CSF2 TNF 3351436 1581114 Positive_regulation CSF2 TNF 7500047 1588522 Positive_regulation CSF2 TNF 7530764 1589967 Positive_regulation CSF2 TNF 7530764 1589992 Positive_regulation CSF2 TNF 7679713 1591416 Positive_regulation CSF2 TNF 8381656 444839 Positive_regulation CSF2 TNF 8382509 444843 Positive_regulation CSF2 TNF 8478614 1595507 Positive_regulation CSF2 TNF 8478614 1595564 Positive_regulation CSF2 TNF 8601605 1450706 Positive_regulation CSF2 TNF 8676060 1597696 Positive_regulation CSF2 TNF 8676080 1597972 Positive_regulation CSF2 TNF 8855987 445732 Positive_regulation CSF2 TNF 9705607 1763610 Positive_regulation CSF2 TNF 9705607 1763640 Positive_regulation CSF2 TNF 9792334 1763755 Positive_regulation CSF2 TNF 9864375 1473483 Positive_regulation CSF3 ABCG2 22252524 3204979 Positive_regulation CSF3 EPHB2 24220695 442479 Positive_regulation CSF3 IL1B 20388227 845610 Positive_regulation CSF3 LBP 23437199 2756171 Positive_regulation CSF3 LBP 23437199 2756177 Positive_regulation CSF3 LBP 23437199 2756178 Positive_regulation CSF3 LBP 23437199 2756184 Positive_regulation CSF3 LBP 23437199 2756185 Positive_regulation CSF3 TLR7 20821041 1491391 Positive_regulation CSF3 TLR7 25386178 915039 Positive_regulation CSF3 TNF 11953891 421555 Positive_regulation CSF3 TNF 1373292 423497 Positive_regulation CSF3 TNF 18371213 110351 Positive_regulation CSF3 TNF 18371213 110361 Positive_regulation CSF3 TNF 21079906 1644332 Positive_regulation CSF3 TNF 24489443 1757416 Positive_regulation CSF3 TNF 2647480 795284 Positive_regulation CSF3 TNF 2647480 795348 Positive_regulation CSF3 TNF 7530764 1589993 Positive_regulation CSF3 TNF 7686211 1591502 Positive_regulation CSF3 TNF 8601605 1450712 Positive_regulation CSF3R IL1B 20388227 845612 Positive_regulation CSK EPHB2 21042538 2479707 Positive_regulation CSK EPHB2 22783258 902302 Positive_regulation CSK TLR7 12975352 1297209 Positive_regulation CSK TNF 19966777 1960923 Positive_regulation CSK TNF 24205328 2875991 Positive_regulation CSK TNF 24205328 2876074 Positive_regulation CSN2 CTGF 20497571 285105 Positive_regulation CSN2 CTGF 20497571 285113 Positive_regulation CSN2 CTGF 20497571 285114 Positive_regulation CSN2 CTGF 20497571 285115 Positive_regulation CSN2 CTGF 20497571 285116 Positive_regulation CSN2 CTGF 20497571 285125 Positive_regulation CSN2 CTGF 20497571 285131 Positive_regulation CSN2 CTGF 20497571 285145 Positive_regulation CSN2 TNF 20594364 465944 Positive_regulation CSN3 CTGF 20497571 285104 Positive_regulation CSN3 CTGF 20497571 285109 Positive_regulation CSN3 CTGF 20497571 285110 Positive_regulation CSN3 CTGF 20497571 285111 Positive_regulation CSN3 CTGF 20497571 285112 Positive_regulation CSN3 CTGF 20497571 285124 Positive_regulation CSN3 CTGF 20497571 285130 Positive_regulation CSN3 CTGF 20497571 285141 Positive_regulation CSNK1A1 AXIN2 25208568 1830681 Positive_regulation CSNK1D NES 15251038 277777 Positive_regulation CSNK1E NES 15251038 277778 Positive_regulation CSPG4 EPHB2 17591920 1341668 Positive_regulation CSPG4 ID1 18519801 706203 Positive_regulation CSPG5 ID1 18519801 706204 Positive_regulation CSRP1 LBP 20530747 729526 Positive_regulation CSRP1 LBP 24743550 3066762 Positive_regulation CSRP1 MAP2K6 23531147 1725677 Positive_regulation CSRP1 TNF 15456513 3177967 Positive_regulation CSRP1 TNF 17704137 2028990 Positive_regulation CSRP1 TNF 17704137 2028994 Positive_regulation CSRP1 TNF 17704137 2028999 Positive_regulation CSRP1 TNF 19503785 1746606 Positive_regulation CSRP1 TNF 21915138 805939 Positive_regulation CSRP1 TNF 22216303 2585481 Positive_regulation CSRP1 TNF 22566859 898996 Positive_regulation CSRP1 TNF 23940726 2832139 Positive_regulation CSRP1 TNF 23946727 695941 Positive_regulation CSRP1 TNF 24381940 186052 Positive_regulation CSRP1 TNF 25247574 1130837 Positive_regulation CSRP1 TNF 25609936 647933 Positive_regulation CSRP1 TNF 9192992 446386 Positive_regulation CST3 TNF 21253577 3050846 Positive_regulation CST6 AHSA1 21253577 3050813 Positive_regulation CST6 CFTR 15279681 315149 Positive_regulation CST6 CSTA 23599812 1641438 Positive_regulation CST6 CSTB 24978053 2985524 Positive_regulation CST6 PRDM9 25568937 2367850 Positive_regulation CST6 PRDX2 19503093 2125530 Positive_regulation CTBP1 EPHB2 21224849 769122 Positive_regulation CTBP1 EPHB2 21224849 769124 Positive_regulation CTBP1 EPHB2 21224849 769141 Positive_regulation CTBP1 EPHB2 24918976 620148 Positive_regulation CTBP1 MAP2K6 21224849 769130 Positive_regulation CTBP1 MAP2K6 21224849 769147 Positive_regulation CTBP1 PGC 22453831 1933604 Positive_regulation CTDP1 PGC 17389765 3071450 Positive_regulation CTDP1 TNF 21298084 2320999 Positive_regulation CTGF ACE 24459483 746207 Positive_regulation CTGF ADORA2A 23663495 128399 Positive_regulation CTGF AGTR2 24459483 746208 Positive_regulation CTGF AGTR2 24678903 856898 Positive_regulation CTGF AKT1 22491319 1933888 Positive_regulation CTGF AKT1 23755163 2801562 Positive_regulation CTGF AKT2 22491319 1933889 Positive_regulation CTGF AKT2 23755163 2801563 Positive_regulation CTGF AKT3 22491319 1933890 Positive_regulation CTGF AKT3 23755163 2801564 Positive_regulation CTGF AMOT 21224387 1190311 Positive_regulation CTGF AMOT 21224387 1190331 Positive_regulation CTGF AMOTL1 21224387 1190312 Positive_regulation CTGF AMOTL1 21224387 1190332 Positive_regulation CTGF ANG 22550475 3075852 Positive_regulation CTGF ANGPT2 21941677 1082287 Positive_regulation CTGF ANGPT2 25132338 19397 Positive_regulation CTGF ANGPT2 25132338 19419 Positive_regulation CTGF ARID1B 22978413 292446 Positive_regulation CTGF BCAR3 25499443 476551 Positive_regulation CTGF BECN1 22684333 541558 Positive_regulation CTGF BMP4 15466481 1312497 Positive_regulation CTGF BMP4 15466481 1312504 Positive_regulation CTGF BMP7 21986574 13489 Positive_regulation CTGF BNIP3 22684333 541559 Positive_regulation CTGF CA2 24244587 2880490 Positive_regulation CTGF CARD9 21436792 83409 Positive_regulation CTGF CASP3 23846227 564058 Positive_regulation CTGF CCL4 22978413 292440 Positive_regulation CTGF CCL4 25310107 3014989 Positive_regulation CTGF CCL4 25310107 3014991 Positive_regulation CTGF CCL4 25310107 3014994 Positive_regulation CTGF CCNA2 18789696 3190783 Positive_regulation CTGF CCNA2 21931747 2554319 Positive_regulation CTGF CCND1 22684333 541566 Positive_regulation CTGF CCND1 22684333 541567 Positive_regulation CTGF CDA 24843491 1493358 Positive_regulation CTGF CDH1 24919189 2979604 Positive_regulation CTGF CDKN1A 22684333 541552 Positive_regulation CTGF CDKN2A 22684333 541553 Positive_regulation CTGF CKAP4 22438586 1801406 Positive_regulation CTGF CKAP4 22438586 1801407 Positive_regulation CTGF CKAP4 22438586 1801408 Positive_regulation CTGF CKAP4 22438586 1801416 Positive_regulation CTGF CKAP4 22438586 1801419 Positive_regulation CTGF COL1A1 16303051 524656 Positive_regulation CTGF COL1A1 24090133 537705 Positive_regulation CTGF COL1A2 16303051 524657 Positive_regulation CTGF COL1A2 24090133 537706 Positive_regulation CTGF CREB1 23902294 344712 Positive_regulation CTGF CREB3 23902294 344713 Positive_regulation CTGF CREB5 23902294 344711 Positive_regulation CTGF CREBBP 22978413 292447 Positive_regulation CTGF CSE 23155386 2716995 Positive_regulation CTGF CSE 23155386 2716997 Positive_regulation CTGF CSF1 19144181 112455 Positive_regulation CTGF CXCL12 25121739 2997285 Positive_regulation CTGF CXCL12 25121739 2997286 Positive_regulation CTGF CXCL12 25121739 2997288 Positive_regulation CTGF CXCL12 25121739 2997317 Positive_regulation CTGF CXCL12 25121739 2997318 Positive_regulation CTGF CXCL12 25121739 2997320 Positive_regulation CTGF CXCL12 25121739 2997323 Positive_regulation CTGF CXCL12 25121739 2997324 Positive_regulation CTGF CXCL12 25121739 2997328 Positive_regulation CTGF CXCL12 25121739 2997329 Positive_regulation CTGF CXCL12 25121739 2997345 Positive_regulation CTGF CXCR2 22566952 900416 Positive_regulation CTGF DCN 24877152 192109 Positive_regulation CTGF DCN 24877152 192112 Positive_regulation CTGF DET1 24015303 2842808 Positive_regulation CTGF DST 22552965 794950 Positive_regulation CTGF DST 22552965 794954 Positive_regulation CTGF E2F1 23902294 344714 Positive_regulation CTGF E2F1 23902294 344812 Positive_regulation CTGF ECM1 17224075 279464 Positive_regulation CTGF ECM1 18789696 3190771 Positive_regulation CTGF ECM1 23946690 1716039 Positive_regulation CTGF ECM1 23946690 1716105 Positive_regulation CTGF ECM1 24558600 1154246 Positive_regulation CTGF ECM1 24637722 2934826 Positive_regulation CTGF ECM2 17224075 279465 Positive_regulation CTGF ECM2 18789696 3190772 Positive_regulation CTGF ECM2 23946690 1716040 Positive_regulation CTGF ECM2 23946690 1716106 Positive_regulation CTGF ECM2 24558600 1154247 Positive_regulation CTGF ECM2 24637722 2934827 Positive_regulation CTGF EDN1 17767742 109031 Positive_regulation CTGF EDN1 17767742 109032 Positive_regulation CTGF EDN1 17767742 109033 Positive_regulation CTGF EDN1 17767742 109034 Positive_regulation CTGF EDN1 17767742 109047 Positive_regulation CTGF EDN1 19014648 854649 Positive_regulation CTGF EDN1 20507556 855037 Positive_regulation CTGF EDN1 21611193 2523795 Positive_regulation CTGF EDN1 21941677 1082286 Positive_regulation CTGF EDN1 22028717 1144832 Positive_regulation CTGF EDN1 22212430 14247 Positive_regulation CTGF EDN1 22802915 2219501 Positive_regulation CTGF EDN1 24015303 2842727 Positive_regulation CTGF EDN1 25121739 2997321 Positive_regulation CTGF EDN2 17767742 109048 Positive_regulation CTGF EDN3 17767742 109049 Positive_regulation CTGF EEF1A2 19088845 2402442 Positive_regulation CTGF EGF 20697347 2133451 Positive_regulation CTGF EGF 20697347 2133452 Positive_regulation CTGF EGF 22135505 3128239 Positive_regulation CTGF EGFR 23175185 548164 Positive_regulation CTGF EGFR 23175185 548189 Positive_regulation CTGF EGR1 23304166 3173802 Positive_regulation CTGF ENG 20871866 1144664 Positive_regulation CTGF ENG 23437087 2755561 Positive_regulation CTGF EPHB2 15608389 1634441 Positive_regulation CTGF EPHB2 17474984 656547 Positive_regulation CTGF EPHB2 17474984 656556 Positive_regulation CTGF EPHB2 17474984 656567 Positive_regulation CTGF EPHB2 20858895 1188520 Positive_regulation CTGF EPHB2 21453480 855647 Positive_regulation CTGF EPHB2 22363806 2602028 Positive_regulation CTGF EPHB2 22363806 2602041 Positive_regulation CTGF EPHB2 22363806 2602044 Positive_regulation CTGF EPHB2 22922731 1086670 Positive_regulation CTGF EPHB2 22938209 533081 Positive_regulation CTGF EPHB2 23383241 2749615 Positive_regulation CTGF EPHB2 23383241 2749633 Positive_regulation CTGF EPHB2 24090133 537571 Positive_regulation CTGF EPS15 25384022 3024583 Positive_regulation CTGF EPS8 25384022 3024584 Positive_regulation CTGF ETS1 16469114 104917 Positive_regulation CTGF ETS1 16469114 104918 Positive_regulation CTGF ETS1 16469114 104919 Positive_regulation CTGF ETS1 16469114 104920 Positive_regulation CTGF ETS1 16469114 104925 Positive_regulation CTGF ETS1 16469114 104936 Positive_regulation CTGF ETS1 16469114 104945 Positive_regulation CTGF ETS1 16469114 104946 Positive_regulation CTGF ETS1 16469114 104955 Positive_regulation CTGF ETS1 22539964 2622610 Positive_regulation CTGF ETS1 22539964 2622611 Positive_regulation CTGF ETS1 22539964 2622612 Positive_regulation CTGF ETS1 22539964 2622627 Positive_regulation CTGF ETS1 22539964 2622628 Positive_regulation CTGF ETS1 22539964 2622629 Positive_regulation CTGF ETS1 22539964 2622639 Positive_regulation CTGF ETS1 22539964 2622641 Positive_regulation CTGF F7 11673116 790174 Positive_regulation CTGF FASLG 22135505 3128238 Positive_regulation CTGF FBN1 21655297 2527848 Positive_regulation CTGF FLI1 16469114 104947 Positive_regulation CTGF FLI1 16469114 104959 Positive_regulation CTGF FLI1 17767743 109058 Positive_regulation CTGF FLI1 23041765 1086775 Positive_regulation CTGF FN1 14668046 830422 Positive_regulation CTGF FN1 18789696 3190773 Positive_regulation CTGF FN1 19259423 488889 Positive_regulation CTGF FN1 19552800 3109694 Positive_regulation CTGF FN1 20497571 285118 Positive_regulation CTGF FN1 24558600 1154248 Positive_regulation CTGF FOXO1 19390991 1478571 Positive_regulation CTGF GPER1 23947803 473690 Positive_regulation CTGF GPER1 24481325 787949 Positive_regulation CTGF GRAP2 15608389 1634442 Positive_regulation CTGF GRAP2 20105289 508007 Positive_regulation CTGF GRAP2 22363806 2602042 Positive_regulation CTGF GRAP2 22363806 2602045 Positive_regulation CTGF HBEGF 22330337 1717963 Positive_regulation CTGF HBEGF 22330337 1717971 Positive_regulation CTGF HGF 20697347 2133453 Positive_regulation CTGF HGF 20697347 2133454 Positive_regulation CTGF HGF 20697347 2133471 Positive_regulation CTGF HMGB1 23696886 2795873 Positive_regulation CTGF HMGCR 11806848 3103648 Positive_regulation CTGF HNRNPF 21723222 981033 Positive_regulation CTGF HNRNPH1 21723222 981034 Positive_regulation CTGF HRAS 17474984 656557 Positive_regulation CTGF HRAS 18827908 3208612 Positive_regulation CTGF HRAS 24090133 537572 Positive_regulation CTGF IFI44 22938209 533070 Positive_regulation CTGF IGF1 21403897 506775 Positive_regulation CTGF IGF1 23690758 3076703 Positive_regulation CTGF IL13 22493582 956884 Positive_regulation CTGF IL13 22593760 900832 Positive_regulation CTGF IL13 22593760 900850 Positive_regulation CTGF IL13 23840855 2817974 Positive_regulation CTGF IL13 24173291 1023845 Positive_regulation CTGF IL1A 19852794 1227777 Positive_regulation CTGF IL6 23227240 2725732 Positive_regulation CTGF IL6 23227240 2725739 Positive_regulation CTGF IL6 23227240 2725746 Positive_regulation CTGF ILK 22574216 2636107 Positive_regulation CTGF JUN 22212430 14231 Positive_regulation CTGF JUN 22212430 14232 Positive_regulation CTGF JUN 22212430 14233 Positive_regulation CTGF JUN 22212430 14234 Positive_regulation CTGF JUN 22212430 14240 Positive_regulation CTGF JUN 22212430 14241 Positive_regulation CTGF JUN 22212430 14253 Positive_regulation CTGF JUN 23227240 2725747 Positive_regulation CTGF JUN 25121739 2997325 Positive_regulation CTGF JUN 25121739 2997330 Positive_regulation CTGF KLF15 23646205 2788756 Positive_regulation CTGF KRAS 17474984 656558 Positive_regulation CTGF KRAS 18827908 3208613 Positive_regulation CTGF KRAS 24090133 537573 Positive_regulation CTGF LAMP1 22684333 541560 Positive_regulation CTGF LPA 18702810 324006 Positive_regulation CTGF LPA 19152120 1478356 Positive_regulation CTGF LPA 19152120 1478377 Positive_regulation CTGF LPA 19152120 1478406 Positive_regulation CTGF LPA 19152120 1478407 Positive_regulation CTGF LPA 19152120 1478418 Positive_regulation CTGF LPA 21702955 260320 Positive_regulation CTGF LPA 22938209 533067 Positive_regulation CTGF LPA 22938209 533068 Positive_regulation CTGF LPA 22938209 533069 Positive_regulation CTGF LPA 22938209 533072 Positive_regulation CTGF LPA 22938209 533074 Positive_regulation CTGF LPA 22938209 533076 Positive_regulation CTGF LPA 23259815 856347 Positive_regulation CTGF LRP1 25514242 1135692 Positive_regulation CTGF LRP6 24455745 186424 Positive_regulation CTGF MAP1LC3A 22684333 541561 Positive_regulation CTGF MAP2K1 17474984 656559 Positive_regulation CTGF MAP2K1 21453480 855648 Positive_regulation CTGF MAP2K1 24090133 537574 Positive_regulation CTGF MAP2K2 17474984 656560 Positive_regulation CTGF MAP2K2 21453480 855649 Positive_regulation CTGF MAP2K2 24090133 537575 Positive_regulation CTGF MAP2K3 17474984 656561 Positive_regulation CTGF MAP2K3 21453480 855650 Positive_regulation CTGF MAP2K3 24090133 537576 Positive_regulation CTGF MAP2K4 17474984 656562 Positive_regulation CTGF MAP2K4 21453480 855651 Positive_regulation CTGF MAP2K4 24090133 537577 Positive_regulation CTGF MAP2K5 17474984 656563 Positive_regulation CTGF MAP2K5 21453480 855652 Positive_regulation CTGF MAP2K5 24090133 537578 Positive_regulation CTGF MAP2K6 17474984 656564 Positive_regulation CTGF MAP2K6 21453480 855653 Positive_regulation CTGF MAP2K6 24090133 537579 Positive_regulation CTGF MAP2K7 17474984 656565 Positive_regulation CTGF MAP2K7 21453480 855654 Positive_regulation CTGF MAP2K7 24090133 537580 Positive_regulation CTGF MAP3K5 23227240 2725740 Positive_regulation CTGF MAPK1 15608389 1634443 Positive_regulation CTGF MAPK1 21481241 332642 Positive_regulation CTGF MAPK1 21760921 2535980 Positive_regulation CTGF MAPK1 22363806 2602029 Positive_regulation CTGF MAPK1 22539964 2622613 Positive_regulation CTGF MAPK1 23383241 2749616 Positive_regulation CTGF MAPK1 24691542 2947949 Positive_regulation CTGF MAPK10 15608389 1634444 Positive_regulation CTGF MAPK10 21481241 332643 Positive_regulation CTGF MAPK10 22363806 2602030 Positive_regulation CTGF MAPK10 22539964 2622614 Positive_regulation CTGF MAPK10 23383241 2749617 Positive_regulation CTGF MAPK10 24691542 2947950 Positive_regulation CTGF MAPK11 15608389 1634445 Positive_regulation CTGF MAPK11 21481241 332644 Positive_regulation CTGF MAPK11 22363806 2602031 Positive_regulation CTGF MAPK11 22539964 2622615 Positive_regulation CTGF MAPK11 23383241 2749618 Positive_regulation CTGF MAPK11 24691542 2947951 Positive_regulation CTGF MAPK12 15608389 1634446 Positive_regulation CTGF MAPK12 21481241 332645 Positive_regulation CTGF MAPK12 22363806 2602032 Positive_regulation CTGF MAPK12 22539964 2622616 Positive_regulation CTGF MAPK12 23383241 2749619 Positive_regulation CTGF MAPK12 24691542 2947952 Positive_regulation CTGF MAPK13 15608389 1634447 Positive_regulation CTGF MAPK13 21481241 332646 Positive_regulation CTGF MAPK13 22363806 2602033 Positive_regulation CTGF MAPK13 22539964 2622617 Positive_regulation CTGF MAPK13 23383241 2749620 Positive_regulation CTGF MAPK13 24691542 2947953 Positive_regulation CTGF MAPK14 15608389 1634448 Positive_regulation CTGF MAPK14 21481241 332647 Positive_regulation CTGF MAPK14 22363806 2602034 Positive_regulation CTGF MAPK14 22539964 2622618 Positive_regulation CTGF MAPK14 23383241 2749621 Positive_regulation CTGF MAPK14 24691542 2947954 Positive_regulation CTGF MAPK15 15608389 1634440 Positive_regulation CTGF MAPK15 21481241 332641 Positive_regulation CTGF MAPK15 22363806 2602027 Positive_regulation CTGF MAPK15 22539964 2622609 Positive_regulation CTGF MAPK15 23383241 2749614 Positive_regulation CTGF MAPK15 24691542 2947948 Positive_regulation CTGF MAPK3 15608389 1634449 Positive_regulation CTGF MAPK3 21481241 332648 Positive_regulation CTGF MAPK3 21760921 2535981 Positive_regulation CTGF MAPK3 22363806 2602035 Positive_regulation CTGF MAPK3 22539964 2622619 Positive_regulation CTGF MAPK3 22586581 722789 Positive_regulation CTGF MAPK3 22938209 533073 Positive_regulation CTGF MAPK3 22938209 533075 Positive_regulation CTGF MAPK3 22938209 533079 Positive_regulation CTGF MAPK3 23383241 2749622 Positive_regulation CTGF MAPK3 24090133 537563 Positive_regulation CTGF MAPK3 24090133 537708 Positive_regulation CTGF MAPK3 24551846 187112 Positive_regulation CTGF MAPK3 24691542 2947955 Positive_regulation CTGF MAPK4 15608389 1634450 Positive_regulation CTGF MAPK4 21481241 332649 Positive_regulation CTGF MAPK4 22363806 2602036 Positive_regulation CTGF MAPK4 22539964 2622620 Positive_regulation CTGF MAPK4 23383241 2749623 Positive_regulation CTGF MAPK4 24691542 2947956 Positive_regulation CTGF MAPK6 15608389 1634451 Positive_regulation CTGF MAPK6 21481241 332650 Positive_regulation CTGF MAPK6 22363806 2602037 Positive_regulation CTGF MAPK6 22539964 2622621 Positive_regulation CTGF MAPK6 23383241 2749624 Positive_regulation CTGF MAPK6 24691542 2947957 Positive_regulation CTGF MAPK7 15608389 1634452 Positive_regulation CTGF MAPK7 21481241 332651 Positive_regulation CTGF MAPK7 22363806 2602038 Positive_regulation CTGF MAPK7 22539964 2622622 Positive_regulation CTGF MAPK7 23383241 2749625 Positive_regulation CTGF MAPK7 24691542 2947958 Positive_regulation CTGF MAPK8 15608389 1634453 Positive_regulation CTGF MAPK8 21481241 332652 Positive_regulation CTGF MAPK8 22363806 2602039 Positive_regulation CTGF MAPK8 22539964 2622623 Positive_regulation CTGF MAPK8 23383241 2749626 Positive_regulation CTGF MAPK8 24691542 2947959 Positive_regulation CTGF MAPK9 15608389 1634454 Positive_regulation CTGF MAPK9 21481241 332653 Positive_regulation CTGF MAPK9 22363806 2602040 Positive_regulation CTGF MAPK9 22539964 2622624 Positive_regulation CTGF MAPK9 23383241 2749627 Positive_regulation CTGF MAPK9 24691542 2947960 Positive_regulation CTGF MARCH8 25031653 1613683 Positive_regulation CTGF MED1 23755364 847462 Positive_regulation CTGF MED10 23755364 847456 Positive_regulation CTGF MED11 23755364 847459 Positive_regulation CTGF MED13 23755364 847443 Positive_regulation CTGF MED13L 23755364 847444 Positive_regulation CTGF MED14 23755364 847448 Positive_regulation CTGF MED15 23755364 847437 Positive_regulation CTGF MED16 23755364 847439 Positive_regulation CTGF MED17 23755364 847450 Positive_regulation CTGF MED18 23755364 847455 Positive_regulation CTGF MED19 23755364 847458 Positive_regulation CTGF MED20 23755364 847438 Positive_regulation CTGF MED21 23755364 847433 Positive_regulation CTGF MED22 23755364 847434 Positive_regulation CTGF MED23 23755364 847449 Positive_regulation CTGF MED24 23755364 847445 Positive_regulation CTGF MED25 23755364 847457 Positive_regulation CTGF MED26 23755364 847451 Positive_regulation CTGF MED27 23755364 847452 Positive_regulation CTGF MED29 23755364 847447 Positive_regulation CTGF MED30 23755364 847446 Positive_regulation CTGF MED31 23755364 847454 Positive_regulation CTGF MED4 23755364 847440 Positive_regulation CTGF MED6 23755364 847441 Positive_regulation CTGF MED7 23755364 847453 Positive_regulation CTGF MED8 23755364 847442 Positive_regulation CTGF MIR18A 21501375 32634 Positive_regulation CTGF MMP1 21098624 1035511 Positive_regulation CTGF MMP10 21098624 1035512 Positive_regulation CTGF MMP11 21098624 1035513 Positive_regulation CTGF MMP12 21098624 1035514 Positive_regulation CTGF MMP13 21098624 1035515 Positive_regulation CTGF MMP14 21098624 1035516 Positive_regulation CTGF MMP15 21098624 1035517 Positive_regulation CTGF MMP16 21098624 1035518 Positive_regulation CTGF MMP17 21098624 1035519 Positive_regulation CTGF MMP19 21098624 1035520 Positive_regulation CTGF MMP2 21098624 1035521 Positive_regulation CTGF MMP20 21098624 1035522 Positive_regulation CTGF MMP21 21098624 1035508 Positive_regulation CTGF MMP24 21098624 1035523 Positive_regulation CTGF MMP25 21098624 1035505 Positive_regulation CTGF MMP26 21098624 1035506 Positive_regulation CTGF MMP27 21098624 1035507 Positive_regulation CTGF MMP28 21098624 1035509 Positive_regulation CTGF MMP3 19152120 1478408 Positive_regulation CTGF MMP3 21098624 1035524 Positive_regulation CTGF MMP7 21098624 1035525 Positive_regulation CTGF MMP8 21098624 1035526 Positive_regulation CTGF MMP9 21098624 1035527 Positive_regulation CTGF MOK 18401458 831380 Positive_regulation CTGF MRXS5 22328559 1035575 Positive_regulation CTGF MRXS5 22328559 1035576 Positive_regulation CTGF MSC 19152120 1478409 Positive_regulation CTGF MUC1 20697347 2133455 Positive_regulation CTGF MUC1 20697347 2133456 Positive_regulation CTGF MUC1 20697347 2133457 Positive_regulation CTGF MUC1 20697347 2133483 Positive_regulation CTGF MYLIP 20062521 2312597 Positive_regulation CTGF MYLIP 21501375 32631 Positive_regulation CTGF MYLIP 21501375 32632 Positive_regulation CTGF MYLIP 21501375 32633 Positive_regulation CTGF MYLIP 21501375 32644 Positive_regulation CTGF MYLIP 21501375 32664 Positive_regulation CTGF MYLIP 21501375 32665 Positive_regulation CTGF MYLIP 21501375 32672 Positive_regulation CTGF MYLIP 23533592 2770763 Positive_regulation CTGF MYLIP 23681229 561812 Positive_regulation CTGF MYLIP 23998897 1481461 Positive_regulation CTGF NCOA3 22978413 292451 Positive_regulation CTGF NOV 21931747 2554316 Positive_regulation CTGF NOV 24722330 2951161 Positive_regulation CTGF NPHP4 21555462 1386894 Positive_regulation CTGF NR3C2 15608389 1634425 Positive_regulation CTGF NR3C2 15608389 1634455 Positive_regulation CTGF NRAS 17474984 656566 Positive_regulation CTGF NRAS 18827908 3208614 Positive_regulation CTGF NRAS 24090133 537581 Positive_regulation CTGF NTRK1 PMC3760629 1606220 Positive_regulation CTGF NUP43 22938209 533071 Positive_regulation CTGF OPA1 23755364 847461 Positive_regulation CTGF OXA1L 23998897 1481462 Positive_regulation CTGF PARP1 19152120 1478447 Positive_regulation CTGF PDGFB 20697347 2133458 Positive_regulation CTGF PDGFB 20697347 2133459 Positive_regulation CTGF PDGFB 20697347 2133480 Positive_regulation CTGF PGF 22328559 1035579 Positive_regulation CTGF PIAS2 20497571 285117 Positive_regulation CTGF PIK3CA 23755163 2801565 Positive_regulation CTGF PIK3R1 23755163 2801566 Positive_regulation CTGF PPP1CA 21909427 2552127 Positive_regulation CTGF PPP1CA 21909427 2552128 Positive_regulation CTGF PROK1 21098624 1035510 Positive_regulation CTGF PROK1 21098624 1035555 Positive_regulation CTGF PROK1 21098624 1035556 Positive_regulation CTGF PROK1 21098624 1035560 Positive_regulation CTGF PROK1 21098624 1035561 Positive_regulation CTGF PROK1 21098624 1035562 Positive_regulation CTGF PROK1 21098624 1035567 Positive_regulation CTGF PROK1 21098624 1035570 Positive_regulation CTGF PROK1 21098624 1035571 Positive_regulation CTGF PROK1 21098624 1035572 Positive_regulation CTGF PROK1 21098624 1035573 Positive_regulation CTGF PRR11 22911790 2676477 Positive_regulation CTGF PRR12 22911790 2676483 Positive_regulation CTGF PRR13 22911790 2676476 Positive_regulation CTGF PRR14 22911790 2676481 Positive_regulation CTGF PRR15 22911790 2676475 Positive_regulation CTGF PRR16 22911790 2676484 Positive_regulation CTGF PRR18 22911790 2676482 Positive_regulation CTGF PRR19 22911790 2676488 Positive_regulation CTGF PRR21 22911790 2676489 Positive_regulation CTGF PRR22 22911790 2676480 Positive_regulation CTGF PRR24 22911790 2676478 Positive_regulation CTGF PRR25 22911790 2676490 Positive_regulation CTGF PRR26 22911790 2676485 Positive_regulation CTGF PRR3 22911790 2676474 Positive_regulation CTGF PRR4 22911790 2676473 Positive_regulation CTGF PRR5 22911790 2676486 Positive_regulation CTGF PRR7 22911790 2676479 Positive_regulation CTGF PRR9 22911790 2676487 Positive_regulation CTGF PTBP1 21723222 981035 Positive_regulation CTGF PTBP2 21723222 981032 Positive_regulation CTGF PTGS2 25122504 2997928 Positive_regulation CTGF PTH 24049536 95877 Positive_regulation CTGF PTH 24049536 95878 Positive_regulation CTGF PTH 24049536 95880 Positive_regulation CTGF PTH 24049536 95881 Positive_regulation CTGF PTH 24049536 95883 Positive_regulation CTGF PTH 24049536 95884 Positive_regulation CTGF PTH 24049536 95885 Positive_regulation CTGF PTH 24049536 95888 Positive_regulation CTGF PTH 24049536 95889 Positive_regulation CTGF PTHLH 24551846 187113 Positive_regulation CTGF PTHLH 25147739 413803 Positive_regulation CTGF RAC1 20205862 397078 Positive_regulation CTGF RAC1 23856044 128773 Positive_regulation CTGF RAC1 23856044 128819 Positive_regulation CTGF RAC1 25121739 2997322 Positive_regulation CTGF RENBP 23946690 1716076 Positive_regulation CTGF RENBP 24634591 1716269 Positive_regulation CTGF RHOA 20858895 1188524 Positive_regulation CTGF RHOA 22942703 1096972 Positive_regulation CTGF RNF19A 24691542 2947947 Positive_regulation CTGF RUNX2 22966907 1866735 Positive_regulation CTGF SATB1 21629692 2525585 Positive_regulation CTGF SERPINF1 23055574 1750631 Positive_regulation CTGF SETD2 21288330 358166 Positive_regulation CTGF SETD2 21304949 2501835 Positive_regulation CTGF SETD2 21304949 2501837 Positive_regulation CTGF SETD2 22162692 1144838 Positive_regulation CTGF SETD2 22684333 541549 Positive_regulation CTGF SETD2 22684333 541570 Positive_regulation CTGF SETD2 22684333 541572 Positive_regulation CTGF SETD2 22684333 541574 Positive_regulation CTGF SETD2 22751431 541579 Positive_regulation CTGF SETD2 23481058 1045254 Positive_regulation CTGF SETD2 23947803 473689 Positive_regulation CTGF SFN 23050040 2225054 Positive_regulation CTGF SHOX 24887312 2975876 Positive_regulation CTGF SMAD1 16390551 3105991 Positive_regulation CTGF SMAD1 21541658 616623 Positive_regulation CTGF SMAD1 21760921 2535979 Positive_regulation CTGF SMAD1 21760921 2535989 Positive_regulation CTGF SMAD1 21931601 2553624 Positive_regulation CTGF SMAD1 22593760 900842 Positive_regulation CTGF SMAD1 23056332 2701200 Positive_regulation CTGF SMAD1 24090133 537707 Positive_regulation CTGF SMAD1 24090133 537717 Positive_regulation CTGF SMAD2 16390551 3105992 Positive_regulation CTGF SMAD2 21152444 2486996 Positive_regulation CTGF SMAD2 21541658 616624 Positive_regulation CTGF SMAD2 21931601 2553625 Positive_regulation CTGF SMAD2 22363627 2601344 Positive_regulation CTGF SMAD2 22593760 900843 Positive_regulation CTGF SMAD2 22978413 292448 Positive_regulation CTGF SMAD2 23056332 2701201 Positive_regulation CTGF SMAD2 24204381 3076833 Positive_regulation CTGF SMAD2 25132338 19406 Positive_regulation CTGF SMAD2 25132338 19430 Positive_regulation CTGF SMAD3 16390551 3105993 Positive_regulation CTGF SMAD3 16469114 104921 Positive_regulation CTGF SMAD3 16469114 104926 Positive_regulation CTGF SMAD3 16469114 104937 Positive_regulation CTGF SMAD3 17485510 1545553 Positive_regulation CTGF SMAD3 18274641 1741521 Positive_regulation CTGF SMAD3 18274641 1741528 Positive_regulation CTGF SMAD3 21541658 616625 Positive_regulation CTGF SMAD3 21931601 2553626 Positive_regulation CTGF SMAD3 22363627 2601345 Positive_regulation CTGF SMAD3 22593760 900844 Positive_regulation CTGF SMAD3 22802915 2219598 Positive_regulation CTGF SMAD3 22966907 1866736 Positive_regulation CTGF SMAD3 22978413 292449 Positive_regulation CTGF SMAD3 23056332 2701202 Positive_regulation CTGF SMAD3 23662065 3209302 Positive_regulation CTGF SMAD3 23755364 847460 Positive_regulation CTGF SMAD3 25132338 19407 Positive_regulation CTGF SMAD3 25132338 19431 Positive_regulation CTGF SMAD4 16390551 3105994 Positive_regulation CTGF SMAD4 18274641 1741522 Positive_regulation CTGF SMAD4 18274641 1741529 Positive_regulation CTGF SMAD4 21189948 1713903 Positive_regulation CTGF SMAD4 21541658 616626 Positive_regulation CTGF SMAD4 21931601 2553627 Positive_regulation CTGF SMAD4 22593760 900845 Positive_regulation CTGF SMAD4 22978413 292450 Positive_regulation CTGF SMAD4 23056332 2701203 Positive_regulation CTGF SMAD5 16390551 3105995 Positive_regulation CTGF SMAD5 21541658 616627 Positive_regulation CTGF SMAD5 21931601 2553628 Positive_regulation CTGF SMAD5 22593760 900846 Positive_regulation CTGF SMAD5 23056332 2701204 Positive_regulation CTGF SMAD6 16390551 3105996 Positive_regulation CTGF SMAD6 21541658 616628 Positive_regulation CTGF SMAD6 21931601 2553629 Positive_regulation CTGF SMAD6 22593760 900847 Positive_regulation CTGF SMAD6 23056332 2701205 Positive_regulation CTGF SMAD7 16390551 3105997 Positive_regulation CTGF SMAD7 16469114 104929 Positive_regulation CTGF SMAD7 21541658 616629 Positive_regulation CTGF SMAD7 21931601 2553630 Positive_regulation CTGF SMAD7 22593760 900848 Positive_regulation CTGF SMAD7 23056332 2701206 Positive_regulation CTGF SMAD7 24090133 537561 Positive_regulation CTGF SMAD7 24090133 537562 Positive_regulation CTGF SMAD9 16390551 3105998 Positive_regulation CTGF SMAD9 21541658 616630 Positive_regulation CTGF SMAD9 21931601 2553631 Positive_regulation CTGF SMAD9 22593760 900849 Positive_regulation CTGF SMAD9 23056332 2701207 Positive_regulation CTGF SMARCA4 22978413 292442 Positive_regulation CTGF SMARCC1 22978413 292443 Positive_regulation CTGF SMARCC2 22978413 292444 Positive_regulation CTGF SNAI1 21920318 700018 Positive_regulation CTGF SOX9 19152120 1478438 Positive_regulation CTGF SOX9 22072985 2327383 Positive_regulation CTGF SPP1 23055574 1750625 Positive_regulation CTGF SRC 19152120 1478439 Positive_regulation CTGF SRC 21760921 2535978 Positive_regulation CTGF SRC PMC3760629 1606219 Positive_regulation CTGF SRF 22563064 739556 Positive_regulation CTGF STAT6 22493582 956883 Positive_regulation CTGF SYT1 16303051 524655 Positive_regulation CTGF TAC1 23166366 805588 Positive_regulation CTGF TAC3 23166366 805589 Positive_regulation CTGF TAC4 23166366 805590 Positive_regulation CTGF TAZ 20972459 2136514 Positive_regulation CTGF TAZ 21224387 1190341 Positive_regulation CTGF TAZ 23755364 847435 Positive_regulation CTGF TAZ 25354978 1887236 Positive_regulation CTGF TAZ 25354978 1887237 Positive_regulation CTGF TAZ 25354978 1887243 Positive_regulation CTGF TAZ 25354978 1887244 Positive_regulation CTGF TAZ 25354978 1887247 Positive_regulation CTGF TAZ 25354978 1887248 Positive_regulation CTGF TAZ 25502757 841177 Positive_regulation CTGF TCF12 22072985 2327387 Positive_regulation CTGF TCF15 22072985 2327388 Positive_regulation CTGF TCF19 22072985 2327389 Positive_regulation CTGF TCF20 22072985 2327390 Positive_regulation CTGF TCF21 22072985 2327391 Positive_regulation CTGF TCF23 22072985 2327395 Positive_regulation CTGF TCF24 22072985 2327397 Positive_regulation CTGF TCF25 22072985 2327396 Positive_regulation CTGF TCF3 22072985 2327392 Positive_regulation CTGF TCF4 22072985 2327393 Positive_regulation CTGF TCF7 22072985 2327394 Positive_regulation CTGF TEAD1 23029054 2694339 Positive_regulation CTGF TEAD2 23029054 2694340 Positive_regulation CTGF TEAD3 23029054 2694341 Positive_regulation CTGF TEAD4 23029054 2694342 Positive_regulation CTGF TEAD4 23755364 847436 Positive_regulation CTGF TGFB1 17333105 732692 Positive_regulation CTGF TGFB1 19152120 1478351 Positive_regulation CTGF TGFB1 19152120 1478352 Positive_regulation CTGF TGFB1 19152120 1478353 Positive_regulation CTGF TGFB1 19152120 1478354 Positive_regulation CTGF TGFB1 19152120 1478355 Positive_regulation CTGF TGFB1 19152120 1478374 Positive_regulation CTGF TGFB1 19152120 1478375 Positive_regulation CTGF TGFB1 19152120 1478376 Positive_regulation CTGF TGFB1 19152120 1478404 Positive_regulation CTGF TGFB1 19152120 1478405 Positive_regulation CTGF TGFB1 19152120 1478414 Positive_regulation CTGF TGFB1 19152120 1478415 Positive_regulation CTGF TGFB1 19152120 1478416 Positive_regulation CTGF TGFB1 19152120 1478417 Positive_regulation CTGF TGFB1 19152120 1478440 Positive_regulation CTGF TGFB1 19152120 1478446 Positive_regulation CTGF TGFB1 19152120 1478465 Positive_regulation CTGF TGFB1 19152120 1478473 Positive_regulation CTGF TGFB1 22319435 2295473 Positive_regulation CTGF TGFB1 24015193 2842201 Positive_regulation CTGF TGFB1 25401052 692032 Positive_regulation CTGF TNF 18827908 3208611 Positive_regulation CTGF TNF 19922639 117856 Positive_regulation CTGF TNF 19922639 117857 Positive_regulation CTGF TNF 19922639 117862 Positive_regulation CTGF TNF 19922639 117863 Positive_regulation CTGF TNF 19922639 117866 Positive_regulation CTGF TNF 19922639 117867 Positive_regulation CTGF TNF 19922639 117875 Positive_regulation CTGF TNF 19922639 117878 Positive_regulation CTGF TNF 21266028 121377 Positive_regulation CTGF TNF 22675458 2648564 Positive_regulation CTGF TNF 22675458 2648568 Positive_regulation CTGF TNF 24015193 2842202 Positive_regulation CTGF TNF 24722330 2951167 Positive_regulation CTGF TNF 24734020 953852 Positive_regulation CTGF TNF 25125479 412868 Positive_regulation CTGF TRIM33 22978413 292445 Positive_regulation CTGF VAMP7 24880616 1964118 Positive_regulation CTGF VEGFA 11806848 3103646 Positive_regulation CTGF VEGFA 17333105 732688 Positive_regulation CTGF VEGFA 17333105 732693 Positive_regulation CTGF VEGFA 18628999 2392930 Positive_regulation CTGF VEGFA 21986574 13483 Positive_regulation CTGF VEGFA 22289291 450754 Positive_regulation CTGF VEGFA 22363445 2599075 Positive_regulation CTGF VEGFA 22911805 2676701 Positive_regulation CTGF VEGFA 24451141 1123101 Positive_regulation CTGF VEGFA 25071162 1577105 Positive_regulation CTGF VEGFA 25237397 856984 Positive_regulation CTGF VEGFA 25237397 856985 Positive_regulation CTGF VEGFA 25237397 856990 Positive_regulation CTGF VEGFA 25237397 856992 Positive_regulation CTGF VEGFA 25237397 856993 Positive_regulation CTGF VEGFA 25237397 856998 Positive_regulation CTGF WNT1 20299474 713175 Positive_regulation CTGF WNT1 20299474 713176 Positive_regulation CTGF WNT1 20299474 713177 Positive_regulation CTGF WNT1 20299474 713178 Positive_regulation CTGF WNT11 20299474 713179 Positive_regulation CTGF WNT11 20299474 713180 Positive_regulation CTGF WNT11 20299474 713181 Positive_regulation CTGF WNT11 20299474 713182 Positive_regulation CTGF WNT16 20299474 713199 Positive_regulation CTGF WNT16 20299474 713200 Positive_regulation CTGF WNT16 20299474 713201 Positive_regulation CTGF WNT16 20299474 713202 Positive_regulation CTGF WNT2 20299474 713183 Positive_regulation CTGF WNT2 20299474 713184 Positive_regulation CTGF WNT2 20299474 713185 Positive_regulation CTGF WNT2 20299474 713186 Positive_regulation CTGF WNT3 20299474 713187 Positive_regulation CTGF WNT3 20299474 713188 Positive_regulation CTGF WNT3 20299474 713189 Positive_regulation CTGF WNT3 20299474 713190 Positive_regulation CTGF WNT3A 20299474 713257 Positive_regulation CTGF WNT4 20299474 713191 Positive_regulation CTGF WNT4 20299474 713192 Positive_regulation CTGF WNT4 20299474 713193 Positive_regulation CTGF WNT4 20299474 713194 Positive_regulation CTGF WNT4 21549744 1733602 Positive_regulation CTGF WNT6 20299474 713195 Positive_regulation CTGF WNT6 20299474 713196 Positive_regulation CTGF WNT6 20299474 713197 Positive_regulation CTGF WNT6 20299474 713198 Positive_regulation CTGF ZEB1 25058589 2992103 Positive_regulation CTHRC1 EPHB2 24504172 2187109 Positive_regulation CTLA4 FAS 24677194 1029706 Positive_regulation CTNNA1 CHI3L1 23665676 2152220 Positive_regulation CTNNA1 TSPAN1 14691142 1302982 Positive_regulation CTNNA1 TSPAN1 14691142 1302983 Positive_regulation CTNNAL1 LEF1 22359570 2597670 Positive_regulation CTNNAL1 LEF1 22359570 2597671 Positive_regulation CTNNAL1 LEF1 22359570 2597672 Positive_regulation CTNNAL1 LEF1 22359570 2597681 Positive_regulation CTNNAL1 LEF1 22359570 2597687 Positive_regulation CTNNAL1 TFAP2A 22359570 2597667 Positive_regulation CTNNAL1 TFAP2A 22359570 2597668 Positive_regulation CTNNAL1 TFAP2A 22359570 2597669 Positive_regulation CTNNAL1 TFAP2A 22359570 2597680 Positive_regulation CTNNAL1 TFAP2A 22359570 2597686 Positive_regulation CTNNB1 AXIN2 24586908 2928381 Positive_regulation CTNNB1 AXIN2 24931005 2192241 Positive_regulation CTNNB1 FZD4 25374452 490093 Positive_regulation CTNNB1 OSR1 24931004 1681294 Positive_regulation CTNNB1 WNT7A 24287629 1939684 Positive_regulation CTNND1 CHI3L1 23665676 2152221 Positive_regulation CTNND1 EPHB2 10477763 1249217 Positive_regulation CTNND1 TSPAN1 14691142 1303026 Positive_regulation CTNND1 TSPAN1 14691142 1303027 Positive_regulation CTNND1 TUB 25193494 978607 Positive_regulation CTR9 ALOX5 8666909 1597093 Positive_regulation CTR9 F2R PMC2756345 496002 Positive_regulation CTR9 GPR115 21079759 3049564 Positive_regulation CTR9 GPR115 25375862 3023487 Positive_regulation CTR9 GPR132 21079759 3049553 Positive_regulation CTR9 GPR132 25375862 3023476 Positive_regulation CTR9 GPR87 21079759 3049633 Positive_regulation CTR9 GPR87 25375862 3023556 Positive_regulation CTR9 LPCAT1 21079759 3049445 Positive_regulation CTR9 LPCAT1 25415055 177546 Positive_regulation CTR9 TNF 18475680 1745376 Positive_regulation CTR9 TNF 18475682 1745389 Positive_regulation CTR9 TNF 18475742 1746298 Positive_regulation CTR9 TNF 21082032 2482398 Positive_regulation CTR9 TNF 2137857 1562736 Positive_regulation CTR9 TNF 2137857 1562747 Positive_regulation CTR9 TNF 21860543 1749383 Positive_regulation CTR9 TNF 2659725 1577675 Positive_regulation CTR9 TNF 3049910 1579716 Positive_regulation CTR9 TNF 3049910 1579717 Positive_regulation CTR9 TNF 3049910 1579718 Positive_regulation CTR9 TNF 3049910 1579719 Positive_regulation CTR9 TNF 3049910 1579773 Positive_regulation CTR9 TNF 3049910 1579787 Positive_regulation CTR9 TNF 3049910 1579797 Positive_regulation CTR9 TNF 3049910 1579802 Positive_regulation CTR9 TNF 3119758 1580113 Positive_regulation CTR9 TNF 3119758 1580114 Positive_regulation CTR9 TNF 3119758 1580115 Positive_regulation CTR9 TNF 3119758 1580116 Positive_regulation CTR9 TNF 3119758 1580117 Positive_regulation CTR9 TNF 3119758 1580169 Positive_regulation CTR9 TNF 7516414 1589275 Positive_regulation CTR9 TNF 7516414 1589280 Positive_regulation CTR9 TNF 7516414 1589300 Positive_regulation CTR9 TNF 7516414 1589305 Positive_regulation CTSB AGR2 24717913 2950407 Positive_regulation CTSB AGR2 24717913 2950414 Positive_regulation CTSB PLAU 20657647 2456284 Positive_regulation CTSB PLAU 21347260 2503464 Positive_regulation CTSB TNF 11381085 1270275 Positive_regulation CTSB TNF 11381085 1270276 Positive_regulation CTSB TNF 22069489 2569226 Positive_regulation CTSB TNF 22693552 2650656 Positive_regulation CTSC EPHB2 24376709 2901881 Positive_regulation CTSC PLAT 25090090 2994827 Positive_regulation CTSD AGR2 24717913 2950408 Positive_regulation CTSD AGR2 24717913 2950415 Positive_regulation CTSG F2R 24453410 1756634 Positive_regulation CTSG GPR115 9271589 1601522 Positive_regulation CTSG GPR132 9271589 1601511 Positive_regulation CTSG GPR87 9271589 1601591 Positive_regulation CTSG ITGB2 23940756 2832201 Positive_regulation CTSG TNF 21569464 1697265 Positive_regulation CTSK CTGF 19922639 117871 Positive_regulation CTSK TNF 23675440 2792961 Positive_regulation CTSL CAPN8 22315674 1669875 Positive_regulation CTSL CST6 23305363 693854 Positive_regulation CTSL MMP28 15579421 792177 Positive_regulation CTSL MMP7 15579421 792193 Positive_regulation CTSL PLAU 8382511 444877 Positive_regulation CTSS CAPN8 9456328 1466385 Positive_regulation CTSS TNF 11381085 1270277 Positive_regulation CTSS TNF 14651749 3095620 Positive_regulation CTSS TNF 15314073 1533238 Positive_regulation CTSS TNF 22844403 2668030 Positive_regulation CUL1 ABCG2 22252524 3204980 Positive_regulation CUL1 EPHB2 21559359 2518495 Positive_regulation CUL1 TNF 25071782 913482 Positive_regulation CX3CL1 EPHB2 19840952 513411 Positive_regulation CX3CL1 TNF 20041188 2436008 Positive_regulation CX3CL1 TNF 22096344 1628238 Positive_regulation CX3CL1 TNF 22566871 899062 Positive_regulation CX3CL1 TNF 22566871 899063 Positive_regulation CX3CL1 TNF 22566871 899067 Positive_regulation CX3CL1 TNF 22566871 899068 Positive_regulation CX3CL1 TNF 22566871 899071 Positive_regulation CX3CL1 TNF 22566871 899074 Positive_regulation CX3CL1 TNF 22943205 645667 Positive_regulation CX3CL1 TNF 23800251 1627053 Positive_regulation CX3CL1 TNF 24098382 2856021 Positive_regulation CX3CL1 TNF 24995121 652236 Positive_regulation CX3CL1 TNF 25353001 1888547 Positive_regulation CX3CR1 TLR7 25024136 1577057 Positive_regulation CXCL1 EPHB2 24223928 2877389 Positive_regulation CXCL1 S1PR3 21887342 2549374 Positive_regulation CXCL1 S1PR3 21887342 2549389 Positive_regulation CXCL1 TNF 19934004 711857 Positive_regulation CXCL1 TNF 23042150 1957909 Positive_regulation CXCL1 TNF 23042150 1957921 Positive_regulation CXCL1 TNF 23300534 2733679 Positive_regulation CXCL1 TNF 23554905 2773630 Positive_regulation CXCL1 TNF 23665907 1106594 Positive_regulation CXCL1 TNF 23665907 1106595 Positive_regulation CXCL1 TNF 23665907 1106611 Positive_regulation CXCL1 TNF 23665907 1106623 Positive_regulation CXCL1 TNF 23840908 2818798 Positive_regulation CXCL1 TNF 23840908 2818814 Positive_regulation CXCL1 TNF 23841502 367168 Positive_regulation CXCL1 TNF 24064574 2118083 Positive_regulation CXCL1 TNF 24580964 1667720 Positive_regulation CXCL1 TNF 24580964 1667721 Positive_regulation CXCL1 TNF 24580964 1667730 Positive_regulation CXCL1 TNF 24580964 1667733 Positive_regulation CXCL1 TNF 24580964 1667735 Positive_regulation CXCL1 TNF 24580964 1667736 Positive_regulation CXCL1 TNF 24580964 1667737 Positive_regulation CXCL1 TNF 24580964 1667738 Positive_regulation CXCL1 TNF 24595131 2930792 Positive_regulation CXCL1 TNF 24595131 2930793 Positive_regulation CXCL1 TNF 24595131 2930809 Positive_regulation CXCL1 TNF 24595131 2930819 Positive_regulation CXCL1 TP63 22606349 2643321 Positive_regulation CXCL10 ARSA 22333315 471144 Positive_regulation CXCL10 EDN2 22004287 3112804 Positive_regulation CXCL10 EPHB2 18221537 3212353 Positive_regulation CXCL10 EPHB2 23034049 3113213 Positive_regulation CXCL10 EPHB2 25415223 2207273 Positive_regulation CXCL10 MAP2K6 22046344 2566512 Positive_regulation CXCL10 SPHK1 24464131 1959658 Positive_regulation CXCL10 TLR7 19360120 3043729 Positive_regulation CXCL10 TLR7 20821041 1491402 Positive_regulation CXCL10 TLR7 22125636 2573647 Positive_regulation CXCL10 TLR7 23236482 2726572 Positive_regulation CXCL10 TLR7 23762283 2802889 Positive_regulation CXCL10 TLR7 23824215 2808913 Positive_regulation CXCL10 TLR7 25222785 1045973 Positive_regulation CXCL10 TNF 11879548 98690 Positive_regulation CXCL10 TNF 12167174 297854 Positive_regulation CXCL10 TNF 16033640 3105149 Positive_regulation CXCL10 TNF 16356198 104907 Positive_regulation CXCL10 TNF 16846531 106213 Positive_regulation CXCL10 TNF 16846531 106214 Positive_regulation CXCL10 TNF 17927586 1030468 Positive_regulation CXCL10 TNF 18046562 1072327 Positive_regulation CXCL10 TNF 18046562 1072328 Positive_regulation CXCL10 TNF 18046562 1072362 Positive_regulation CXCL10 TNF 18046562 1072372 Positive_regulation CXCL10 TNF 18489763 1727785 Positive_regulation CXCL10 TNF 18957084 1620496 Positive_regulation CXCL10 TNF 19197385 2405266 Positive_regulation CXCL10 TNF 19197385 2405267 Positive_regulation CXCL10 TNF 19197385 2405268 Positive_regulation CXCL10 TNF 19197385 2405270 Positive_regulation CXCL10 TNF 19197385 2405271 Positive_regulation CXCL10 TNF 19197385 2405273 Positive_regulation CXCL10 TNF 19442267 1696262 Positive_regulation CXCL10 TNF 19442267 1696263 Positive_regulation CXCL10 TNF 19442267 1696278 Positive_regulation CXCL10 TNF 19442267 1696279 Positive_regulation CXCL10 TNF 19442267 1696281 Positive_regulation CXCL10 TNF 19582151 2420923 Positive_regulation CXCL10 TNF 19686583 116595 Positive_regulation CXCL10 TNF 19934004 711832 Positive_regulation CXCL10 TNF 20495997 598963 Positive_regulation CXCL10 TNF 20733031 1559594 Positive_regulation CXCL10 TNF 21508508 736864 Positive_regulation CXCL10 TNF 21708014 123045 Positive_regulation CXCL10 TNF 21708014 123047 Positive_regulation CXCL10 TNF 21853018 2542822 Positive_regulation CXCL10 TNF 21857970 2544485 Positive_regulation CXCL10 TNF 21857970 2544503 Positive_regulation CXCL10 TNF 21857970 2544532 Positive_regulation CXCL10 TNF 22022590 2563976 Positive_regulation CXCL10 TNF 22022590 2563984 Positive_regulation CXCL10 TNF 22022590 2563985 Positive_regulation CXCL10 TNF 22110387 1058542 Positive_regulation CXCL10 TNF 22233170 354867 Positive_regulation CXCL10 TNF 22333315 471143 Positive_regulation CXCL10 TNF 22387292 84435 Positive_regulation CXCL10 TNF 22387292 84495 Positive_regulation CXCL10 TNF 22547990 3152639 Positive_regulation CXCL10 TNF 22860050 2671409 Positive_regulation CXCL10 TNF 23034049 3113181 Positive_regulation CXCL10 TNF 23034049 3113182 Positive_regulation CXCL10 TNF 23034049 3113186 Positive_regulation CXCL10 TNF 23034049 3113187 Positive_regulation CXCL10 TNF 23034049 3113188 Positive_regulation CXCL10 TNF 23034049 3113194 Positive_regulation CXCL10 TNF 23034049 3113196 Positive_regulation CXCL10 TNF 23078780 1665095 Positive_regulation CXCL10 TNF 23078780 1665101 Positive_regulation CXCL10 TNF 23227188 2725679 Positive_regulation CXCL10 TNF 23717673 2798738 Positive_regulation CXCL10 TNF 23717673 2798740 Positive_regulation CXCL10 TNF 23762160 820139 Positive_regulation CXCL10 TNF 23762160 820142 Positive_regulation CXCL10 TNF 23800251 1627051 Positive_regulation CXCL10 TNF 23824685 2809244 Positive_regulation CXCL10 TNF 23841502 367167 Positive_regulation CXCL10 TNF 23882269 908244 Positive_regulation CXCL10 TNF 23922745 2826362 Positive_regulation CXCL10 TNF 23922745 2826371 Positive_regulation CXCL10 TNF 23983678 3076721 Positive_regulation CXCL10 TNF 24064574 2118063 Positive_regulation CXCL10 TNF 24489443 1757414 Positive_regulation CXCL10 TNF 24516541 2921100 Positive_regulation CXCL10 TNF 24648846 1156512 Positive_regulation CXCL10 TNF 24648846 1156513 Positive_regulation CXCL10 TNF 24648846 1156527 Positive_regulation CXCL10 TNF 24648846 1156533 Positive_regulation CXCL10 TNF 24659862 1757637 Positive_regulation CXCL10 TNF 24659862 1757828 Positive_regulation CXCL10 TNF 24945146 2980861 Positive_regulation CXCL10 TNF 25214710 1762087 Positive_regulation CXCL10 TNF 25253920 1762386 Positive_regulation CXCL10 TNF 25431758 948889 Positive_regulation CXCL10 TP63 22606349 2643318 Positive_regulation CXCL11 EDN2 22004287 3112807 Positive_regulation CXCL11 TNF 12167174 297856 Positive_regulation CXCL11 TNF 16033640 3105151 Positive_regulation CXCL11 TNF 16033640 3105166 Positive_regulation CXCL11 TNF 19686583 116597 Positive_regulation CXCL11 TNF 19934004 711833 Positive_regulation CXCL11 TNF 22233170 354868 Positive_regulation CXCL11 TNF 24064574 2118064 Positive_regulation CXCL11 TNF 24516541 2921102 Positive_regulation CXCL11 TNF 24586980 2928508 Positive_regulation CXCL11 TNF 24586980 2928509 Positive_regulation CXCL11 TNF 24586980 2928510 Positive_regulation CXCL11 TNF 24586980 2928539 Positive_regulation CXCL11 TNF 24586980 2928540 Positive_regulation CXCL11 TNF 24586980 2928541 Positive_regulation CXCL11 TNF 25431758 948890 Positive_regulation CXCL12 ANGPT1 22558265 2624905 Positive_regulation CXCL12 CTGF 25121739 2997283 Positive_regulation CXCL12 EPHB2 20010845 1953418 Positive_regulation CXCL12 EPHB2 21045835 436123 Positive_regulation CXCL12 EPHB2 22412835 2609291 Positive_regulation CXCL12 EPHB2 22472349 1698235 Positive_regulation CXCL12 EPHB2 22472349 1698236 Positive_regulation CXCL12 EPHB2 23098564 1231465 Positive_regulation CXCL12 EPHB2 24058588 2848118 Positive_regulation CXCL12 EPHB2 24058588 2848120 Positive_regulation CXCL12 EPHB2 24886617 475000 Positive_regulation CXCL12 F2R 24834915 2970970 Positive_regulation CXCL12 HBEGF 20946648 1859848 Positive_regulation CXCL12 HBEGF 20946648 1859872 Positive_regulation CXCL12 HBEGF 20946648 1859879 Positive_regulation CXCL12 HBEGF 23888518 3185317 Positive_regulation CXCL12 ITGAL PMC3871424 1478216 Positive_regulation CXCL12 MMP28 22675496 2649019 Positive_regulation CXCL12 MMP28 24472670 411626 Positive_regulation CXCL12 MMP7 22675496 2649034 Positive_regulation CXCL12 MMP7 24472670 411641 Positive_regulation CXCL12 NR2F1 24906407 273669 Positive_regulation CXCL12 PLAU 23098564 1231472 Positive_regulation CXCL12 PTGER2 22934275 2161409 Positive_regulation CXCL12 S1PR3 19002266 2400310 Positive_regulation CXCL12 TCN1 24735601 1667965 Positive_regulation CXCL12 TCN1 24735601 1667966 Positive_regulation CXCL12 TCN1 24735601 1667967 Positive_regulation CXCL12 TCN1 24735601 1667972 Positive_regulation CXCL12 TCN1 24735601 1667973 Positive_regulation CXCL12 TCN1 24735601 1667990 Positive_regulation CXCL12 TCN1 24735601 1667991 Positive_regulation CXCL12 TCN1 24735601 1667994 Positive_regulation CXCL12 TCN1 24735601 1667995 Positive_regulation CXCL12 TCN1 24735601 1667998 Positive_regulation CXCL12 TCN1 24735601 1668006 Positive_regulation CXCL12 TCN1 24735601 1668007 Positive_regulation CXCL12 TNF 16507142 104995 Positive_regulation CXCL12 TNF 18371213 110344 Positive_regulation CXCL12 TNF 18371213 110360 Positive_regulation CXCL12 TNF 19934004 711838 Positive_regulation CXCL12 TNF 22675496 2649014 Positive_regulation CXCL12 TNF 24064574 2118069 Positive_regulation CXCL12 TNF 25774937 134112 Positive_regulation CXCL13 TNF 19934004 711834 Positive_regulation CXCL13 TNF 24064574 2118065 Positive_regulation CXCL13 TNFSF10 22194670 3152397 Positive_regulation CXCL14 TNF 19934004 711835 Positive_regulation CXCL14 TNF 24064574 2118066 Positive_regulation CXCL16 TNF 19415545 834008 Positive_regulation CXCL16 TNF 19690611 2424219 Positive_regulation CXCL16 TNF 19934004 711855 Positive_regulation CXCL16 TNF 20981357 1079646 Positive_regulation CXCL16 TNF 22879901 2672901 Positive_regulation CXCL16 TNF 22879901 2672906 Positive_regulation CXCL16 TNF 23056624 2702453 Positive_regulation CXCL16 TNF 23800251 1627121 Positive_regulation CXCL16 TNF 23800251 1627155 Positive_regulation CXCL16 TNF 23800251 1627175 Positive_regulation CXCL16 TNF 24064574 2118079 Positive_regulation CXCL16 TNF 24130892 2867510 Positive_regulation CXCL16 TNF 24130892 2867522 Positive_regulation CXCL16 TNF 24130892 2867529 Positive_regulation CXCL16 TNF 24460887 734560 Positive_regulation CXCL17 TNF 19934004 711856 Positive_regulation CXCL17 TNF 24064574 2118081 Positive_regulation CXCL2 CHI3L1 24399973 963259 Positive_regulation CXCL2 CHI3L1 24399973 963266 Positive_regulation CXCL2 TLR7 18584038 3072595 Positive_regulation CXCL2 TLR7 18584038 3072690 Positive_regulation CXCL2 TLR7 18584038 3072691 Positive_regulation CXCL2 TLR7 18584038 3073135 Positive_regulation CXCL2 TLR7 18584038 3073557 Positive_regulation CXCL2 TNF 19934004 711858 Positive_regulation CXCL2 TNF 20001970 147379 Positive_regulation CXCL2 TNF 23554905 2773632 Positive_regulation CXCL2 TNF 24064574 2118084 Positive_regulation CXCL2 TNF 24223177 2876611 Positive_regulation CXCL2 TNF 24590763 1575106 Positive_regulation CXCL3 F2R 21029417 354094 Positive_regulation CXCL3 F2R 21029417 354096 Positive_regulation CXCL3 TNF 19934004 711859 Positive_regulation CXCL3 TNF 24064574 2118085 Positive_regulation CXCL5 EPHB2 21682898 122979 Positive_regulation CXCL5 F2R 21029417 353990 Positive_regulation CXCL5 F2R 21029417 354068 Positive_regulation CXCL5 F2R 21029417 354090 Positive_regulation CXCL5 IL1B 19954533 2232844 Positive_regulation CXCL5 IL1B 21176181 3099682 Positive_regulation CXCL5 TNF 19934004 711836 Positive_regulation CXCL5 TNF 24064574 2118067 Positive_regulation CXCL5 TNF 24603712 2931987 Positive_regulation CXCL6 TNF 19686583 116569 Positive_regulation CXCL6 TNF 19934004 711837 Positive_regulation CXCL6 TNF 24064574 2118068 Positive_regulation CXCL9 ARSA 22333315 471145 Positive_regulation CXCL9 ARSA 22333315 471146 Positive_regulation CXCL9 CD22 11994425 1523384 Positive_regulation CXCL9 EDN2 22004287 3112819 Positive_regulation CXCL9 TLR7 15154616 630231 Positive_regulation CXCL9 TLR7 15154616 630270 Positive_regulation CXCL9 TLR7 23110209 2707093 Positive_regulation CXCL9 TNF 11696601 1521795 Positive_regulation CXCL9 TNF 12167174 297858 Positive_regulation CXCL9 TNF 15154616 630230 Positive_regulation CXCL9 TNF 16033640 3105159 Positive_regulation CXCL9 TNF 19686583 116601 Positive_regulation CXCL9 TNF 19934004 711862 Positive_regulation CXCL9 TNF 21203448 2490423 Positive_regulation CXCL9 TNF 21569348 363006 Positive_regulation CXCL9 TNF 21853018 2542827 Positive_regulation CXCL9 TNF 22233170 354869 Positive_regulation CXCL9 TNF 24064574 2118087 Positive_regulation CXCL9 TNF 24516541 2921104 Positive_regulation CXCL9 TNF 25251568 3010152 Positive_regulation CXCL9 TNF PMC3332453 134782 Positive_regulation CXCR2 PPBP 22850671 771970 Positive_regulation CXCR2 TNF 18268919 1071588 Positive_regulation CXCR2 TNF 19281078 1071696 Positive_regulation CXCR2 TNF 24613851 701444 Positive_regulation CXCR3 TNF 16603445 630432 Positive_regulation CXCR3 TNF 24613851 701445 Positive_regulation CXCR4 ANGPT1 22558265 2624907 Positive_regulation CXCR4 EPHB2 19106094 1165219 Positive_regulation CXCR4 EPHB2 23987636 1700325 Positive_regulation CXCR4 EPHB2 25514788 3034642 Positive_regulation CXCR4 EPHB2 25514788 3034675 Positive_regulation CXCR4 FOXO1 21143873 331791 Positive_regulation CXCR4 FOXO1 21143873 331797 Positive_regulation CXCR4 ID1 22139302 1879455 Positive_regulation CXCR4 MMP28 19363519 7322 Positive_regulation CXCR4 MMP28 24472670 411658 Positive_regulation CXCR4 MMP7 19363519 7337 Positive_regulation CXCR4 MMP7 24472670 411673 Positive_regulation CXCR4 PTGER2 20705717 1885358 Positive_regulation CXCR4 PTGER2 20705717 1885425 Positive_regulation CXCR4 PTGER2 20705717 1885426 Positive_regulation CXCR4 PTGER2 20705717 1885484 Positive_regulation CXCR4 S1PR3 25077607 2993398 Positive_regulation CXCR4 TLR7 22745793 2656533 Positive_regulation CXCR4 TNF 20142991 845597 Positive_regulation CXCR4 TNF 20596251 1911726 Positive_regulation CXCR4 TNF 20699000 257073 Positive_regulation CXCR4 TNF 20699000 257074 Positive_regulation CXCR4 TNF 20699000 257075 Positive_regulation CXCR4 TNF 20699000 257076 Positive_regulation CXCR4 TNF 20699000 257081 Positive_regulation CXCR4 TNF 21508508 736870 Positive_regulation CXCR4 TNF 23800251 1627156 Positive_regulation CXCR4 TNF 23986795 2220468 Positive_regulation CXCR4 TNF 24384839 1122810 Positive_regulation CXCR4 TNF 25196285 3224108 Positive_regulation CXCR4 TNF 25527973 1736357 Positive_regulation CXCR4 TNF 25527973 1736360 Positive_regulation CXCR5 EPHB2 23742646 3121846 Positive_regulation CXCR5 TNF 9892622 1605083 Positive_regulation CXCR6 TNF 19690611 2424220 Positive_regulation CYBB TNF 21845170 1076847 Positive_regulation CYBB TNF 23451244 2758436 Positive_regulation CYBB TNF 23691105 2794525 Positive_regulation CYBB TNF 23983473 3209351 Positive_regulation CYBB TNF 24396568 2228000 Positive_regulation CYBB TNF 8102388 1594064 Positive_regulation CYCS ARL4D 22927989 2681283 Positive_regulation CYCS CAPN8 23865001 3092030 Positive_regulation CYCS CCND1 25105148 196083 Positive_regulation CYCS EPHB2 23028726 2692705 Positive_regulation CYCS EPHB2 23470533 560768 Positive_regulation CYCS FAS 10075978 1511220 Positive_regulation CYCS FAS 18769617 2396031 Positive_regulation CYCS FAS 19001123 1359741 Positive_regulation CYCS FAS 23690674 1753129 Positive_regulation CYCS LGALS7B 21289092 1786159 Positive_regulation CYCS LGALS7B 21289092 1786165 Positive_regulation CYCS MIP 21347304 2503555 Positive_regulation CYCS MMP28 11602639 1521432 Positive_regulation CYCS MMP28 15312229 3115312 Positive_regulation CYCS MMP28 22096572 2571774 Positive_regulation CYCS MMP28 22833097 557213 Positive_regulation CYCS MMP28 23348590 559195 Positive_regulation CYCS MMP28 23861719 821400 Positive_regulation CYCS MMP28 24566142 1124147 Positive_regulation CYCS MMP28 25505905 23456 Positive_regulation CYCS MMP7 11602639 1521447 Positive_regulation CYCS MMP7 15312229 3115327 Positive_regulation CYCS MMP7 22096572 2571789 Positive_regulation CYCS MMP7 22833097 557228 Positive_regulation CYCS MMP7 23348590 559210 Positive_regulation CYCS MMP7 23861719 821415 Positive_regulation CYCS MMP7 24566142 1124163 Positive_regulation CYCS MMP7 25505905 23472 Positive_regulation CYCS PGC 19435887 1165959 Positive_regulation CYCS PGC 19435887 1165976 Positive_regulation CYCS PGC 22548174 1155567 Positive_regulation CYCS TGM2 20665636 774904 Positive_regulation CYCS TNF 10839812 1515690 Positive_regulation CYCS TNF 10839812 1515691 Positive_regulation CYCS TNF 21298033 2499372 Positive_regulation CYCS TNF 21490804 1638338 Positive_regulation CYCS TNF 21799887 2538960 Positive_regulation CYCS TNF 24817082 2963256 Positive_regulation CYCS TNF 24834056 965140 Positive_regulation CYCS TNF 25216531 2199943 Positive_regulation CYCS TNFSF10 17718901 1645603 Positive_regulation CYCS TNFSF10 22932446 834914 Positive_regulation CYCS TNFSF10 22932446 834916 Positive_regulation CYCS TNFSF10 23254290 558418 Positive_regulation CYCS TNFSF10 24603337 572757 Positive_regulation CYCS TNFSF10 25149175 2198228 Positive_regulation CYLD EPHB2 25389768 3025154 Positive_regulation CYLD PDE4B 23575688 1935964 Positive_regulation CYLD PDE4B 23575688 1935968 Positive_regulation CYLD PDE4B 23575688 1935969 Positive_regulation CYLD PDE4B 23575688 1935972 Positive_regulation CYLD TNF 21824392 519953 Positive_regulation CYLD TNF 24098568 2858187 Positive_regulation CYP11A1 TNF 20439544 1558182 Positive_regulation CYP11B1 TNF 20439544 1558180 Positive_regulation CYP17A1 MAMLD1 21559465 2519596 Positive_regulation CYP17A1 MAMLD1 21559465 2519599 Positive_regulation CYP17A1 MAMLD1 21559465 2519600 Positive_regulation CYP19A1 EPHB2 23875162 647276 Positive_regulation CYP19A1 TNF 19809499 2427868 Positive_regulation CYP19A1 TNF 19809499 2427869 Positive_regulation CYP19A1 TNF 19809499 2427870 Positive_regulation CYP19A1 TNF 19809499 2427871 Positive_regulation CYP19A1 TNF 19809499 2427877 Positive_regulation CYP19A1 TNF 19809499 2427879 Positive_regulation CYP19A1 TNF 19809499 2427883 Positive_regulation CYP19A1 TNF 19809499 2427885 Positive_regulation CYP19A1 TNF 19809499 2427887 Positive_regulation CYP19A1 TNF 22125453 3152137 Positive_regulation CYP1A1 IFI27 24351910 1730469 Positive_regulation CYP1A1 TNF 22866165 1239692 Positive_regulation CYP1B1 TNF 19835593 2232835 Positive_regulation CYP1B1 TNF 19835593 2232838 Positive_regulation CYP1B1 TNF 22866165 1239693 Positive_regulation CYP24A1 ABCA1 19787078 981264 Positive_regulation CYP24A1 AHSA1 19015318 1361159 Positive_regulation CYP24A1 CAMP 23424670 2755213 Positive_regulation CYP24A1 CAMP 23805323 2808449 Positive_regulation CYP24A1 CREB1 19015318 1361185 Positive_regulation CYP24A1 CREB3 19015318 1361186 Positive_regulation CYP24A1 CREB5 19015318 1361184 Positive_regulation CYP24A1 CYP27B1 20730630 616347 Positive_regulation CYP24A1 CYP27B1 20730630 616511 Positive_regulation CYP24A1 CYP27B1 20730630 616553 Positive_regulation CYP24A1 CYP27B1 20831823 257222 Positive_regulation CYP24A1 FGF23 20730630 616348 Positive_regulation CYP24A1 FGF23 20730630 616512 Positive_regulation CYP24A1 FGF23 20730630 616513 Positive_regulation CYP24A1 FGF23 20730630 616554 Positive_regulation CYP24A1 FGF23 21716585 1711962 Positive_regulation CYP24A1 FGF23 22359666 2598702 Positive_regulation CYP24A1 FGF23 23825530 2809528 Positive_regulation CYP24A1 FGF23 23857223 2117623 Positive_regulation CYP24A1 FGF23 24258305 787515 Positive_regulation CYP24A1 IGFBP3 24782782 964715 Positive_regulation CYP24A1 IL4 23595134 2117302 Positive_regulation CYP24A1 MAP2K1 22272032 1694223 Positive_regulation CYP24A1 MAP2K2 22272032 1694224 Positive_regulation CYP24A1 MAP2K3 22272032 1694225 Positive_regulation CYP24A1 MAP2K4 22272032 1694226 Positive_regulation CYP24A1 MAP2K5 22272032 1694227 Positive_regulation CYP24A1 MAP2K6 22272032 1694228 Positive_regulation CYP24A1 MAP2K7 22272032 1694229 Positive_regulation CYP24A1 MAPK1 19015318 1361161 Positive_regulation CYP24A1 MAPK1 22577546 1139574 Positive_regulation CYP24A1 MAPK10 19015318 1361162 Positive_regulation CYP24A1 MAPK10 22577546 1139575 Positive_regulation CYP24A1 MAPK11 19015318 1361163 Positive_regulation CYP24A1 MAPK11 22577546 1139576 Positive_regulation CYP24A1 MAPK12 19015318 1361164 Positive_regulation CYP24A1 MAPK12 22577546 1139577 Positive_regulation CYP24A1 MAPK13 19015318 1361165 Positive_regulation CYP24A1 MAPK13 22577546 1139578 Positive_regulation CYP24A1 MAPK14 19015318 1361166 Positive_regulation CYP24A1 MAPK14 22577546 1139579 Positive_regulation CYP24A1 MAPK15 19015318 1361160 Positive_regulation CYP24A1 MAPK15 22577546 1139573 Positive_regulation CYP24A1 MAPK3 19015318 1361167 Positive_regulation CYP24A1 MAPK3 22577546 1139580 Positive_regulation CYP24A1 MAPK4 19015318 1361168 Positive_regulation CYP24A1 MAPK4 22577546 1139581 Positive_regulation CYP24A1 MAPK6 19015318 1361169 Positive_regulation CYP24A1 MAPK6 22577546 1139582 Positive_regulation CYP24A1 MAPK7 19015318 1361170 Positive_regulation CYP24A1 MAPK7 22577546 1139583 Positive_regulation CYP24A1 MAPK8 19015318 1361171 Positive_regulation CYP24A1 MAPK8 22577546 1139584 Positive_regulation CYP24A1 MAPK9 19015318 1361172 Positive_regulation CYP24A1 MAPK9 22577546 1139585 Positive_regulation CYP24A1 NR1I2 19240808 2014606 Positive_regulation CYP24A1 NR1I2 19240808 2014607 Positive_regulation CYP24A1 PIM1 22720752 377706 Positive_regulation CYP24A1 PIM1 22720752 377707 Positive_regulation CYP24A1 PLEC 17074929 1543131 Positive_regulation CYP24A1 PTH 24175086 647954 Positive_regulation CYP24A1 RHOA 19015318 1360246 Positive_regulation CYP24A1 ROCK1 19015318 1360244 Positive_regulation CYP24A1 ROCK2 19015318 1360245 Positive_regulation CYP24A1 RPS6KA5 19015318 1361158 Positive_regulation CYP24A1 SENP1 24586832 2927222 Positive_regulation CYP24A1 SPP1 19015318 1361183 Positive_regulation CYP24A1 TLR1 21124742 2484015 Positive_regulation CYP24A1 TLR10 21124742 2484023 Positive_regulation CYP24A1 TLR2 21124742 2484016 Positive_regulation CYP24A1 TLR3 21124742 2484017 Positive_regulation CYP24A1 TLR4 21124742 2484018 Positive_regulation CYP24A1 TLR5 21124742 2484019 Positive_regulation CYP24A1 TLR6 21124742 2484024 Positive_regulation CYP24A1 TLR7 21124742 2484020 Positive_regulation CYP24A1 TLR8 21124742 2484021 Positive_regulation CYP24A1 TLR9 21124742 2484022 Positive_regulation CYP24A1 VDR 19240808 2014626 Positive_regulation CYP24A1 VDR 19240808 2014627 Positive_regulation CYP24A1 VDR 19787078 981267 Positive_regulation CYP24A1 VDR 21179018 1903865 Positive_regulation CYP24A1 VDR 22720752 377705 Positive_regulation CYP24A1 VDR 24729717 1162560 Positive_regulation CYP24A1 VDR 24782782 964714 Positive_regulation CYP26B1 TNF 21249211 2493459 Positive_regulation CYP27B1 CYP24A1 20730630 616349 Positive_regulation CYP27B1 CYP24A1 20730630 616555 Positive_regulation CYP27B1 CYP24A1 20831823 257223 Positive_regulation CYP27B1 TLR7 22286305 1962074 Positive_regulation CYP27B1 TLR7 22286305 1962102 Positive_regulation CYP27B1 TLR7 25089904 2994791 Positive_regulation CYP2A6 MAP2K6 22530035 2620982 Positive_regulation CYP2E1 ENPP1 23168575 2235797 Positive_regulation CYP2E1 TNF 24192824 1121482 Positive_regulation CYP2R1 CYP24A1 22649423 875518 Positive_regulation CYP3A CYP24A1 19015318 1361190 Positive_regulation CYP3A4 ABCA4 23391793 1045245 Positive_regulation CYP7A1 PGC 23964012 781875 Positive_regulation CYP7A1 PGC 23964012 781882 Positive_regulation CYP7A1 TNF 16277680 104626 Positive_regulation CYP7A1 TNF 16277680 104627 Positive_regulation CYP7A1 TNF 16277680 104628 Positive_regulation CYP7A1 TNF 16277680 104629 Positive_regulation CYP7A1 TNF 16277680 104630 Positive_regulation CYP7A1 TNF 16277680 104631 Positive_regulation CYP7A1 TNF 16277680 104632 Positive_regulation CYP7A1 TNF 16277680 104633 Positive_regulation CYP7A1 TNF 16277680 104634 Positive_regulation CYP7A1 TNF 16277680 104635 Positive_regulation CYP7A1 TNF 16277680 104667 Positive_regulation CYP7A1 TNF 16277680 104670 Positive_regulation CYP7A1 TNF 16277680 104671 Positive_regulation CYP7A1 TNF 16277680 104672 Positive_regulation CYP7A1 TNF 16277680 104688 Positive_regulation CYP7A1 TNF 16277680 104689 Positive_regulation CYP7A1 TNF 16277680 104690 Positive_regulation CYP7A1 TNF 16277680 104691 Positive_regulation CYP7A1 TNF 16277680 104692 Positive_regulation CYP7A1 TNF 16277680 104693 Positive_regulation CYP7A1 TNF 16277680 104696 Positive_regulation CYP7A1 TNF 16277680 104697 Positive_regulation CYP7A1 TNF 16277680 104698 Positive_regulation CYP7A1 TNF 16277680 104701 Positive_regulation CYP7A1 TNF 16277680 104702 Positive_regulation CYP7A1 TNF 16277680 104704 Positive_regulation CYP7A1 TNF 16277680 104705 Positive_regulation CYP7A1 TNF 16277680 104706 Positive_regulation CYR61 F2R 25407528 1134479 Positive_regulation CYR61 F3 23535544 3134655 Positive_regulation CYR61 MAP2K6 20663135 256848 Positive_regulation CYR61 TNF 17106732 1643937 Positive_regulation CYR61 TNF 17106732 1643942 Positive_regulation CYSLTR1 ALOX5 22259262 648099 Positive_regulation CYSLTR2 ALOX5 22259262 648100 Positive_regulation CYTIP MIP 25232720 2372943 Positive_regulation DAB1 EFNB1 23318582 610928 Positive_regulation DAB1 EPHB2 23318582 610930 Positive_regulation DAB1 EPHB2 23318582 610931 Positive_regulation DAG1 MMP28 16585265 1539870 Positive_regulation DAG1 MMP7 16585265 1539885 Positive_regulation DAP EPHB2 21042538 2479712 Positive_regulation DAP EPHB2 22870324 2672415 Positive_regulation DAP IFI27 17088910 428319 Positive_regulation DAP IFI27 17088910 428320 Positive_regulation DAPK1 AGAP2 21460185 1789359 Positive_regulation DAPK1 AKR1C4 22246465 2170834 Positive_regulation DAPK1 CA2 21408167 2507141 Positive_regulation DAPK1 CA2 24938416 3082525 Positive_regulation DAPK1 CALM3 21408167 2507142 Positive_regulation DAPK1 CALM3 24710477 618369 Positive_regulation DAPK1 CALM3 25309853 647292 Positive_regulation DAPK1 CDKN2A 22230750 3226420 Positive_regulation DAPK1 CEBPA 25140166 927253 Positive_regulation DAPK1 CTGF 23175185 548169 Positive_regulation DAPK1 MAPK1 23880846 1108915 Positive_regulation DAPK1 MYLIP 23717626 2798518 Positive_regulation DAPK1 NAB1 22160140 2170570 Positive_regulation DAPK1 NAB1 22160140 2170571 Positive_regulation DAPK1 NAB1 22160140 2170578 Positive_regulation DAPK1 NAB1 22160140 2170579 Positive_regulation DAPK1 NAB2 22160140 2170572 Positive_regulation DAPK1 NAB2 22160140 2170573 Positive_regulation DAPK1 NAB2 22160140 2170580 Positive_regulation DAPK1 NAB2 22160140 2170581 Positive_regulation DAPK1 PDCD1 22160140 2170524 Positive_regulation DAPK1 PDCD10 22160140 2170525 Positive_regulation DAPK1 PDCD11 22160140 2170523 Positive_regulation DAPK1 PDCD2 22160140 2170526 Positive_regulation DAPK1 PDCD4 22160140 2170527 Positive_regulation DAPK1 PDCD5 22160140 2170528 Positive_regulation DAPK1 PDCD6 22160140 2170529 Positive_regulation DAPK1 PDCD7 22160140 2170530 Positive_regulation DAPK1 PKD1 22095288 547639 Positive_regulation DAPK1 PKD1 22095288 547674 Positive_regulation DAPK1 PKD2 22095288 547640 Positive_regulation DAPK1 PKD2 22095288 547675 Positive_regulation DAPK1 PKD3 22095288 547641 Positive_regulation DAPK1 PKD3 22095288 547676 Positive_regulation DAPK1 PRDX2 20048748 8922 Positive_regulation DAPK1 PRDX2 20048748 8925 Positive_regulation DAPK1 TP53 24710481 618670 Positive_regulation DAPK1 UNC5B 15956977 426254 Positive_regulation DAPK1 UTRN 23880846 1108914 Positive_regulation DAPK2 CTGF 23175185 548170 Positive_regulation DAPK2 KRT38 23166623 2718190 Positive_regulation DAPK2 UNC5B 15956977 426255 Positive_regulation DAPK3 CTGF 23175185 548171 Positive_regulation DAPK3 UNC5B 15956977 426256 Positive_regulation DAXX FAS 14612908 423777 Positive_regulation DAXX FAS 15123887 1212208 Positive_regulation DBH FOXO1 25353004 1888786 Positive_regulation DBH FOXO1 25353004 1888788 Positive_regulation DBH FOXO1 25353004 1888790 Positive_regulation DBH WNT7A 25170755 3003827 Positive_regulation DBH WNT7A 25170755 3003906 Positive_regulation DCAF7 IFI27 21328542 775882 Positive_regulation DCN CTGF 24877152 192113 Positive_regulation DCP1A EPHB2 23637887 2786472 Positive_regulation DCP1A EPHB2 23637887 2786587 Positive_regulation DCP1A EPHB2 23637887 2786593 Positive_regulation DCP2 RNASE1 25200086 2104740 Positive_regulation DCP2 RNASE7 25200086 2104748 Positive_regulation DCT EPHB2 24129178 1113307 Positive_regulation DCT MAP2K6 24129178 1113313 Positive_regulation DCT TGM2 25009701 206384 Positive_regulation DCTN1 IFI27 22918948 1806774 Positive_regulation DCTN1 IFI27 22918948 1806863 Positive_regulation DCTN1 IFI27 22918948 1806864 Positive_regulation DCTN1 IFI27 22918948 1806884 Positive_regulation DCTN1 NES 15251038 277786 Positive_regulation DCTN2 IFI27 22918948 1806776 Positive_regulation DCTN2 IFI27 22918948 1806867 Positive_regulation DCTN2 IFI27 22918948 1806868 Positive_regulation DCTN2 IFI27 22918948 1806886 Positive_regulation DCTN2 NES 15251038 277787 Positive_regulation DCTN3 IFI27 22918948 1806778 Positive_regulation DCTN3 IFI27 22918948 1806871 Positive_regulation DCTN3 IFI27 22918948 1806872 Positive_regulation DCTN3 IFI27 22918948 1806888 Positive_regulation DCTN3 NES 15251038 277788 Positive_regulation DCTN4 IFI27 22918948 1806768 Positive_regulation DCTN4 IFI27 22918948 1806851 Positive_regulation DCTN4 IFI27 22918948 1806852 Positive_regulation DCTN4 IFI27 22918948 1806878 Positive_regulation DCTN6 IFI27 22918948 1806772 Positive_regulation DCTN6 IFI27 22918948 1806859 Positive_regulation DCTN6 IFI27 22918948 1806860 Positive_regulation DCTN6 IFI27 22918948 1806882 Positive_regulation DCX MAP2K6 23865384 388507 Positive_regulation DDC FOXA1 25249938 871284 Positive_regulation DDIT3 EGLN3 24809345 2358986 Positive_regulation DDIT3 TNFSF10 24525736 572096 Positive_regulation DDIT3 TNFSF10 24525736 572112 Positive_regulation DDIT3 TNFSF10 24525736 572113 Positive_regulation DDIT3 TNFSF10 24525736 572114 Positive_regulation DDIT4 FOXO1 24982916 193598 Positive_regulation DDIT4 MAP2K6 23272222 2730185 Positive_regulation DDX20 SMN2 17984321 1346215 Positive_regulation DDX20 SMN2 18791638 2396491 Positive_regulation DDX20 SMN2 20019802 2312150 Positive_regulation DDX20 SMN2 21339974 1090567 Positive_regulation DDX20 SMN2 21490958 2324096 Positive_regulation DDX20 SMN2 23615451 1813971 Positive_regulation DDX20 SMN2 23615451 1814142 Positive_regulation DDX20 SMN2 23631896 1881523 Positive_regulation DDX20 TNF 24237934 1481917 Positive_regulation DDX21 MAP2K6 25260534 475732 Positive_regulation DDX53 TNFSF10 21264227 2494871 Positive_regulation DDX58 TLR7 21079690 3049435 Positive_regulation DEFA1B JAG1 24971082 913145 Positive_regulation DEFB103B TNF 20104491 808100 Positive_regulation DEFB103B TNF 20104491 808101 Positive_regulation DEFB103B TNF 22389759 1675391 Positive_regulation DEFB103B TNF 25134478 1049876 Positive_regulation DEFB4A TLR7 19503839 2418572 Positive_regulation DEFB4A TLR7 19503839 2418601 Positive_regulation DEFB4A TLR7 19503839 2418633 Positive_regulation DEFB4A TLR7 22286305 1962086 Positive_regulation DEFB4A TLR7 24600406 964393 Positive_regulation DEFB4B EPHB2 22498979 3079523 Positive_regulation DEFB4B HBEGF 20195469 2441898 Positive_regulation DEFB4B TLR7 23554537 3620 Positive_regulation DEFB4B TLR7 23554537 3640 Positive_regulation DEFB4B TLR7 25079443 1128824 Positive_regulation DEFB4B TNF 11667978 3102821 Positive_regulation DEFB4B TNF 18362142 1163760 Positive_regulation DEFB4B TNF 22389759 1675389 Positive_regulation DEFB4B TNF 23555696 2774939 Positive_regulation DEFB4B TNF 25134478 1049872 Positive_regulation DEPDC1B EPHB2 25091805 1234411 Positive_regulation DEPDC1B EPHB2 25091805 1234502 Positive_regulation DERL1 TNF 19193236 365526 Positive_regulation DES FAS 22087162 1028602 Positive_regulation DES TNF 18519735 1352448 Positive_regulation DES TNF 24971321 193313 Positive_regulation DFFB MSX1 22254040 2115986 Positive_regulation DFFB PLAU 19500428 253511 Positive_regulation DGCR14 F2R 23940457 2283786 Positive_regulation DHH KRT38 18648544 2393605 Positive_regulation DHH PODXL 18648544 2393612 Positive_regulation DHX58 TNF 24455433 3151153 Positive_regulation DIABLO FAS 19001123 1359742 Positive_regulation DIABLO ITGB2 11097209 702096 Positive_regulation DIABLO LGALS7B 21289092 1786160 Positive_regulation DIABLO LGALS7B 21289092 1786166 Positive_regulation DIABLO TNF 21738708 2533439 Positive_regulation DIABLO TNFSF10 17718901 1645605 Positive_regulation DIABLO TNFSF10 19895686 254582 Positive_regulation DIABLO TNFSF10 19895686 254599 Positive_regulation DIABLO TNFSF10 21364655 549973 Positive_regulation DIABLO TNFSF10 21364655 549980 Positive_regulation DIABLO TNFSF10 21364655 550003 Positive_regulation DIABLO TNFSF10 21364655 550005 Positive_regulation DIABLO TNFSF10 22723988 2655528 Positive_regulation DIABLO TNFSF10 PMC2243052 1475549 Positive_regulation DIANPH SPON2 22235198 832500 Positive_regulation DIAPH1 EPHB2 23325789 1811330 Positive_regulation DICER1 RNASE1 15918769 2258374 Positive_regulation DIO1 TNF 20808947 2473079 Positive_regulation DIO2 TNF 20808947 2473080 Positive_regulation DIO3 EPHB2 19107595 1027478 Positive_regulation DIO3 TNF 20808947 2473081 Positive_regulation DISC1 EPHB2 25013758 194480 Positive_regulation DISC1 FAS 12163562 1524382 Positive_regulation DISC1 FAS 15795317 1319313 Positive_regulation DISC1 FAS 17130290 1335149 Positive_regulation DISC1 FAS 21151158 12240 Positive_regulation DISC1 FAS 23404198 93268 Positive_regulation DISC1 FAS 23584398 218460 Positive_regulation DISC1 FAS 23584398 218461 Positive_regulation DISC1 FAS 23584398 218476 Positive_regulation DISC1 FAS 23584398 218477 Positive_regulation DISC1 FAS 24204853 2874455 Positive_regulation DISC1 FAS 24204853 2874458 Positive_regulation DISC1 FAS 24204853 2874468 Positive_regulation DISC1 FAS 24639873 1070442 Positive_regulation DISC1 FAS 24874731 576372 Positive_regulation DISC1 FAS 25259610 3010528 Positive_regulation DISC1 TNFSF10 18992144 251757 Positive_regulation DISC1 TNFSF10 18992144 251771 Positive_regulation DISC1 TNFSF10 21049020 2480458 Positive_regulation DISC1 TNFSF10 21272366 258532 Positive_regulation DISC1 TNFSF10 21738740 2533575 Positive_regulation DISC1 TNFSF10 22348197 497087 Positive_regulation DISC1 TNFSF10 23190604 558162 Positive_regulation DISC1 TNFSF10 23429289 560239 Positive_regulation DISC1 TNFSF10 24948009 548925 Positive_regulation DISC1 TNFSF10 25379355 1243425 Positive_regulation DISC2 EPHB2 25013758 194481 Positive_regulation DISC2 FAS 12163562 1524383 Positive_regulation DISC2 FAS 15795317 1319314 Positive_regulation DISC2 FAS 17130290 1335150 Positive_regulation DISC2 FAS 21151158 12243 Positive_regulation DISC2 FAS 23404198 93270 Positive_regulation DISC2 FAS 23584398 218464 Positive_regulation DISC2 FAS 23584398 218465 Positive_regulation DISC2 FAS 23584398 218480 Positive_regulation DISC2 FAS 23584398 218481 Positive_regulation DISC2 FAS 24204853 2874456 Positive_regulation DISC2 FAS 24204853 2874459 Positive_regulation DISC2 FAS 24204853 2874469 Positive_regulation DISC2 FAS 24639873 1070443 Positive_regulation DISC2 FAS 24874731 576373 Positive_regulation DISC2 FAS 25259610 3010530 Positive_regulation DISC2 TNFSF10 18992144 251759 Positive_regulation DISC2 TNFSF10 18992144 251772 Positive_regulation DISC2 TNFSF10 21049020 2480460 Positive_regulation DISC2 TNFSF10 21272366 258533 Positive_regulation DISC2 TNFSF10 21738740 2533576 Positive_regulation DISC2 TNFSF10 22348197 497088 Positive_regulation DISC2 TNFSF10 23190604 558164 Positive_regulation DISC2 TNFSF10 23429289 560240 Positive_regulation DISC2 TNFSF10 24948009 548926 Positive_regulation DISC2 TNFSF10 25379355 1243426 Positive_regulation DKC1 JAG1 22351600 778077 Positive_regulation DKC1 JAG1 22351600 778094 Positive_regulation DKC1 JAG1 22351600 778103 Positive_regulation DKC1 JAG1 22351600 778107 Positive_regulation DKC1 MAP2K6 23409030 2753295 Positive_regulation DKC1 TNF 24580841 3169887 Positive_regulation DKC1 ZFP57 25032857 577403 Positive_regulation DKC1 ZFP57 25032857 577475 Positive_regulation DKK1 CCND1 24586847 2927335 Positive_regulation DKK1 CLU 23164821 1901013 Positive_regulation DKK1 TNF 19183433 112615 Positive_regulation DKK1 TNF 19439035 113291 Positive_regulation DKK1 TNF 19439035 113302 Positive_regulation DKK1 TNF 19497136 113474 Positive_regulation DKK1 TNF 21438671 6597 Positive_regulation DKK1 TNF 21438671 6602 Positive_regulation DKK1 TNF 21861862 123803 Positive_regulation DKK1 TNF 22477520 694252 Positive_regulation DKK1 TNF 23509994 380254 Positive_regulation DKK1 TNF 23709258 694292 Positive_regulation DKK1 TNF 24031147 3230649 Positive_regulation DKK1 TNF 24250816 2881723 Positive_regulation DKK1 TNF 24250816 2881724 Positive_regulation DKK1 TNF 24432364 131314 Positive_regulation DKK1 TNF 24592264 911243 Positive_regulation DKK1 TNF 24839355 1758670 Positive_regulation DKK1 TNF PMC3007788 1702487 Positive_regulation DKK1 TNF PMC3007788 1702492 Positive_regulation DLAT TLR7 17162370 630590 Positive_regulation DLD TNF 7519620 1436167 Positive_regulation DLG1 FAS 18070911 1346770 Positive_regulation DLG1 FAS 18070911 1346771 Positive_regulation DLG1 FAS 18070911 1346772 Positive_regulation DLG1 FAS 18070911 1346802 Positive_regulation DLG1 FAS 18070911 1346818 Positive_regulation DLG2 FAS 18070911 1346773 Positive_regulation DLG2 FAS 18070911 1346774 Positive_regulation DLG2 FAS 18070911 1346775 Positive_regulation DLG2 FAS 18070911 1346803 Positive_regulation DLG2 FAS 18070911 1346819 Positive_regulation DLG3 FAS 18070911 1346776 Positive_regulation DLG3 FAS 18070911 1346777 Positive_regulation DLG3 FAS 18070911 1346778 Positive_regulation DLG3 FAS 18070911 1346804 Positive_regulation DLG3 FAS 18070911 1346820 Positive_regulation DLG4 CAPN8 25393018 3025373 Positive_regulation DLG4 EPHB2 22832728 3189158 Positive_regulation DLG4 EPHB2 22832728 3189175 Positive_regulation DLG4 FAS 18070911 1346779 Positive_regulation DLG4 FAS 18070911 1346780 Positive_regulation DLG4 FAS 18070911 1346781 Positive_regulation DLG4 FAS 18070911 1346805 Positive_regulation DLG4 FAS 18070911 1346821 Positive_regulation DLG4 WNT7A 24223536 867765 Positive_regulation DLG4 WNT7A 24223536 867766 Positive_regulation DLG5 FAS 18070911 1346782 Positive_regulation DLG5 FAS 18070911 1346783 Positive_regulation DLG5 FAS 18070911 1346784 Positive_regulation DLG5 FAS 18070911 1346806 Positive_regulation DLG5 FAS 18070911 1346822 Positive_regulation DLL1 JAG1 18445292 301339 Positive_regulation DLL1 MAP2K6 21418646 305036 Positive_regulation DLL1 TLR7 22072963 3054556 Positive_regulation DLL1 TNF 22190977 633866 Positive_regulation DLL1 TNF 23531541 1103799 Positive_regulation DLL4 ANGPT1 21923938 3207413 Positive_regulation DLL4 ANGPT1 23161900 91129 Positive_regulation DLL4 JAG1 20016694 1160897 Positive_regulation DLL4 JAG1 23967210 2834855 Positive_regulation DLL4 TLR7 25610519 3225759 Positive_regulation DLX2 MSX1 24799899 1674614 Positive_regulation DM1 TNF 20885816 672562 Positive_regulation DMBT1 TNF 23238132 651893 Positive_regulation DMD TMOD1 12975349 1297003 Positive_regulation DMD TMOD1 12975349 1297072 Positive_regulation DMD TMOD1 21727195 1389794 Positive_regulation DMD TMOD1 24430868 1820490 Positive_regulation DMD TMOD1 24586196 2357070 Positive_regulation DMD TNF 20814569 2473445 Positive_regulation DMD TNNT2 24043862 1610592 Positive_regulation DMP1 CCND1 19671193 253935 Positive_regulation DMP1 EPHB2 21836819 648260 Positive_regulation DMP1 MAP2K6 21836819 648266 Positive_regulation DMP1 TGM2 23762828 182007 Positive_regulation DNAJC14 NT5E 21249176 3050353 Positive_regulation DNASE1 RNASE1 20087351 434391 Positive_regulation DNASE1 RNASE1 24722984 1209375 Positive_regulation DNASE1 RNASE7 20087351 434399 Positive_regulation DNASE1 RNASE7 24722984 1209383 Positive_regulation DNMT1 EPHB2 22559742 398586 Positive_regulation DNMT1 EPHB2 22559742 398596 Positive_regulation DNMT1 EPHB2 24358134 2898649 Positive_regulation DNMT1 STK39 21619587 243981 Positive_regulation DNMT1 TNF 21765477 2141232 Positive_regulation DNMT3A ANKRD1 25478012 803927 Positive_regulation DOK1 ANGPT1 24013716 2842145 Positive_regulation DOK2 ANGPT1 24013716 2842146 Positive_regulation DOK3 ANGPT1 24013716 2842141 Positive_regulation DOK4 ANGPT1 24013716 2842140 Positive_regulation DOK5 ANGPT1 24013716 2842139 Positive_regulation DOK5 MAP2K6 24551065 2922922 Positive_regulation DOK6 ANGPT1 24013716 2842144 Positive_regulation DOK7 ANGPT1 24013716 2842143 Positive_regulation DOLK TF 6470046 1433602 Positive_regulation DONSON FOXA1 23919967 2184008 Positive_regulation DONSON UGT1A7 22669291 650425 Positive_regulation DPAGT1 SYNM 24250714 824185 Positive_regulation DPM1 TNF 24152138 1232657 Positive_regulation DPM2 TNF 24152138 1232659 Positive_regulation DPM3 TNF 24152138 1232661 Positive_regulation DPP3 RAB31 22848547 2669646 Positive_regulation DPP3 RAB31 22848547 2669673 Positive_regulation DPP4 F3 22167343 142814 Positive_regulation DPP4 F3 22167343 142837 Positive_regulation DPP4 GLP1R 24148218 510372 Positive_regulation DPP4 TNF 19690650 178080 Positive_regulation DPP4 TNF 24920931 731596 Positive_regulation DPP4 TNF 24920931 731597 Positive_regulation DPP4 TNF 24920931 731598 Positive_regulation DPP4 TNF 24920931 731602 Positive_regulation DRG1 TCN1 24735601 1667978 Positive_regulation DRG1 TNF 18404427 3087215 Positive_regulation DRG1 TNF 20146792 1656093 Positive_regulation DRG2 TCN1 24735601 1667979 Positive_regulation DRG2 TNF 18404427 3087216 Positive_regulation DRG2 TNF 20146792 1656094 Positive_regulation DSC1 GJB2 24931423 1681365 Positive_regulation DSC1 GJB4 24931423 1681367 Positive_regulation DSC2 GJB2 24931423 1681372 Positive_regulation DSC2 GJB4 24931423 1681374 Positive_regulation DSC3 GJB2 24931423 1681379 Positive_regulation DSC3 GJB4 24931423 1681381 Positive_regulation DSG3 PKP1 24646797 1632643 Positive_regulation DSP PKP1 10747098 1257010 Positive_regulation DSP PKP1 24646797 1632644 Positive_regulation DSP SELL 17683640 411722 Positive_regulation DSPP NES 23258378 1143284 Positive_regulation DSPP TGM2 23762828 182008 Positive_regulation DST CTGF 22552965 794946 Positive_regulation DST EPHB2 19538739 1696320 Positive_regulation DSTN SCIN 24155741 879368 Positive_regulation DUOX1 TLR7 24455491 864919 Positive_regulation DUOX1 TLR7 24455491 864960 Positive_regulation DUOX2 TLR7 23349873 2743749 Positive_regulation DUOX2 TLR7 24455491 864909 Positive_regulation DUOX2 TLR7 24455491 864940 Positive_regulation DUSP1 ANGPT1 24308939 1158440 Positive_regulation DUSP1 ANGPT1 24308939 1158441 Positive_regulation DUSP1 ANGPT1 24308939 1158442 Positive_regulation DUSP1 ANGPT1 24308939 1158591 Positive_regulation DUSP1 ANGPT1 24308939 1158592 Positive_regulation DUSP1 ANGPT1 24308939 1158708 Positive_regulation DUSP1 ANGPT1 24308939 1158922 Positive_regulation DUSP1 ANGPT1 24308939 1158996 Positive_regulation DUSP1 ANGPT1 24308939 1159001 Positive_regulation DUSP1 EPHB2 11435472 1519581 Positive_regulation DUSP1 EPHB2 11435472 1519602 Positive_regulation DUSP1 EPHB2 18504304 1551362 Positive_regulation DUSP1 EPHB2 19897477 1167284 Positive_regulation DUSP1 EPHB2 20547488 1188117 Positive_regulation DUSP1 EPHB2 21253577 3050524 Positive_regulation DUSP1 EPHB2 21547253 1749057 Positive_regulation DUSP1 EPHB2 21647446 2527472 Positive_regulation DUSP1 EPHB2 22235371 1687007 Positive_regulation DUSP1 EPHB2 22701344 1060389 Positive_regulation DUSP1 EPHB2 23006971 2181243 Positive_regulation DUSP1 EPHB2 23861901 2820698 Positive_regulation DUSP1 EPHB2 24212770 498192 Positive_regulation DUSP1 EPHB2 24244156 3064955 Positive_regulation DUSP1 EPHB2 24244156 3064957 Positive_regulation DUSP1 EPHB2 24244156 3064958 Positive_regulation DUSP1 EPHB2 24244156 3064959 Positive_regulation DUSP1 EPHB2 25310910 810334 Positive_regulation DUSP1 TNF 24707477 188376 Positive_regulation DUSP1 TNF 24707477 188387 Positive_regulation DUSP1 TNF 24707477 188388 Positive_regulation DUSP1 TNF 24842373 1576396 Positive_regulation DUSP1 TNF 24887434 132700 Positive_regulation DUSP10 ANGPT1 24308939 1158443 Positive_regulation DUSP10 ANGPT1 24308939 1158594 Positive_regulation DUSP10 EPHB2 21647446 2527473 Positive_regulation DUSP10 EPHB2 23006971 2181244 Positive_regulation DUSP10 TLR7 21892172 1955770 Positive_regulation DUSP10 TNF 24707477 188377 Positive_regulation DUSP10 TNF 24707477 188389 Positive_regulation DUSP10 TNF 24707477 188390 Positive_regulation DUSP11 ANGPT1 24308939 1158444 Positive_regulation DUSP11 ANGPT1 24308939 1158596 Positive_regulation DUSP11 EPHB2 21647446 2527474 Positive_regulation DUSP11 EPHB2 23006971 2181245 Positive_regulation DUSP12 ANGPT1 24308939 1158445 Positive_regulation DUSP12 ANGPT1 24308939 1158598 Positive_regulation DUSP12 EPHB2 21647446 2527475 Positive_regulation DUSP12 EPHB2 23006971 2181246 Positive_regulation DUSP13 ANGPT1 24308939 1158434 Positive_regulation DUSP13 ANGPT1 24308939 1158581 Positive_regulation DUSP13 EPHB2 21647446 2527467 Positive_regulation DUSP13 EPHB2 23006971 2181238 Positive_regulation DUSP14 ANGPT1 24308939 1158430 Positive_regulation DUSP14 ANGPT1 24308939 1158573 Positive_regulation DUSP14 EPHB2 21647446 2527463 Positive_regulation DUSP14 EPHB2 23006971 2181234 Positive_regulation DUSP15 ANGPT1 24308939 1158429 Positive_regulation DUSP15 ANGPT1 24308939 1158571 Positive_regulation DUSP15 EPHB2 21647446 2527462 Positive_regulation DUSP15 EPHB2 23006971 2181233 Positive_regulation DUSP16 ANGPT1 24308939 1158431 Positive_regulation DUSP16 ANGPT1 24308939 1158575 Positive_regulation DUSP16 EPHB2 21647446 2527464 Positive_regulation DUSP16 EPHB2 23006971 2181235 Positive_regulation DUSP16 RGS2 25077541 577805 Positive_regulation DUSP16 RGS2 25077541 577818 Positive_regulation DUSP16 RGS2 25077541 577837 Positive_regulation DUSP18 ANGPT1 24308939 1158432 Positive_regulation DUSP18 ANGPT1 24308939 1158577 Positive_regulation DUSP18 EPHB2 21647446 2527465 Positive_regulation DUSP18 EPHB2 23006971 2181236 Positive_regulation DUSP19 ANGPT1 24308939 1158433 Positive_regulation DUSP19 ANGPT1 24308939 1158579 Positive_regulation DUSP19 EPHB2 21647446 2527466 Positive_regulation DUSP19 EPHB2 23006971 2181237 Positive_regulation DUSP2 ANGPT1 24308939 1158446 Positive_regulation DUSP2 ANGPT1 24308939 1158600 Positive_regulation DUSP2 EPHB2 21647446 2527476 Positive_regulation DUSP2 EPHB2 23006971 2181247 Positive_regulation DUSP2 EPHB2 24367002 1574284 Positive_regulation DUSP21 ANGPT1 24308939 1158435 Positive_regulation DUSP21 ANGPT1 24308939 1158583 Positive_regulation DUSP21 EPHB2 21647446 2527468 Positive_regulation DUSP21 EPHB2 23006971 2181239 Positive_regulation DUSP22 ANGPT1 24308939 1158428 Positive_regulation DUSP22 ANGPT1 24308939 1158569 Positive_regulation DUSP22 EPHB2 21647446 2527461 Positive_regulation DUSP22 EPHB2 23006971 2181232 Positive_regulation DUSP23 ANGPT1 24308939 1158436 Positive_regulation DUSP23 ANGPT1 24308939 1158585 Positive_regulation DUSP23 EPHB2 21647446 2527469 Positive_regulation DUSP23 EPHB2 23006971 2181240 Positive_regulation DUSP26 ANGPT1 24308939 1158439 Positive_regulation DUSP26 ANGPT1 24308939 1158589 Positive_regulation DUSP26 EPHB2 21647446 2527471 Positive_regulation DUSP26 EPHB2 23006971 2181242 Positive_regulation DUSP27 ANGPT1 24308939 1158438 Positive_regulation DUSP27 ANGPT1 24308939 1158587 Positive_regulation DUSP27 EPHB2 21647446 2527470 Positive_regulation DUSP27 EPHB2 23006971 2181241 Positive_regulation DUSP28 ANGPT1 24308939 1158458 Positive_regulation DUSP28 ANGPT1 24308939 1158616 Positive_regulation DUSP28 EPHB2 21647446 2527484 Positive_regulation DUSP28 EPHB2 23006971 2181255 Positive_regulation DUSP3 ANGPT1 24308939 1158447 Positive_regulation DUSP3 ANGPT1 24308939 1158602 Positive_regulation DUSP3 EPHB2 21647446 2527477 Positive_regulation DUSP3 EPHB2 23006971 2181248 Positive_regulation DUSP4 ANGPT1 24308939 1158448 Positive_regulation DUSP4 ANGPT1 24308939 1158449 Positive_regulation DUSP4 ANGPT1 24308939 1158450 Positive_regulation DUSP4 ANGPT1 24308939 1158604 Positive_regulation DUSP4 ANGPT1 24308939 1158710 Positive_regulation DUSP4 ANGPT1 24308939 1158820 Positive_regulation DUSP4 ANGPT1 24308939 1158924 Positive_regulation DUSP4 ANGPT1 24308939 1158942 Positive_regulation DUSP4 ANGPT1 24308939 1158994 Positive_regulation DUSP4 ANGPT1 24308939 1159002 Positive_regulation DUSP4 EPHB2 21647446 2527478 Positive_regulation DUSP4 EPHB2 23006971 2181249 Positive_regulation DUSP4 EPHB2 24658355 2188360 Positive_regulation DUSP5 ANGPT1 24308939 1158451 Positive_regulation DUSP5 ANGPT1 24308939 1158452 Positive_regulation DUSP5 ANGPT1 24308939 1158453 Positive_regulation DUSP5 ANGPT1 24308939 1158606 Positive_regulation DUSP5 ANGPT1 24308939 1158926 Positive_regulation DUSP5 ANGPT1 24308939 1158927 Positive_regulation DUSP5 ANGPT1 24308939 1158997 Positive_regulation DUSP5 ANGPT1 24308939 1159003 Positive_regulation DUSP5 EPHB2 19861649 505915 Positive_regulation DUSP5 EPHB2 21647446 2527479 Positive_regulation DUSP5 EPHB2 23006971 2181250 Positive_regulation DUSP5 EPHB2 23060802 959285 Positive_regulation DUSP5 FAS 19667130 1367780 Positive_regulation DUSP6 ANGPT1 24308939 1158454 Positive_regulation DUSP6 ANGPT1 24308939 1158608 Positive_regulation DUSP6 EPHB2 18321244 145538 Positive_regulation DUSP6 EPHB2 18321244 145539 Positive_regulation DUSP6 EPHB2 19578332 1931064 Positive_regulation DUSP6 EPHB2 19578332 1931065 Positive_regulation DUSP6 EPHB2 19861649 505908 Positive_regulation DUSP6 EPHB2 19897477 1167285 Positive_regulation DUSP6 EPHB2 21151572 2485149 Positive_regulation DUSP6 EPHB2 21647446 2527480 Positive_regulation DUSP6 EPHB2 21647446 2527487 Positive_regulation DUSP6 EPHB2 23006971 2181251 Positive_regulation DUSP6 EPHB2 23023500 1962429 Positive_regulation DUSP6 EPHB2 23823128 2808696 Positive_regulation DUSP6 MAP2K6 19390590 2414894 Positive_regulation DUSP6 TP63 23246965 2151189 Positive_regulation DUSP7 ANGPT1 24308939 1158455 Positive_regulation DUSP7 ANGPT1 24308939 1158610 Positive_regulation DUSP7 EPHB2 21647446 2527481 Positive_regulation DUSP7 EPHB2 23006971 2181252 Positive_regulation DUSP8 ANGPT1 24308939 1158456 Positive_regulation DUSP8 ANGPT1 24308939 1158612 Positive_regulation DUSP8 EPHB2 21647446 2527482 Positive_regulation DUSP8 EPHB2 23006971 2181253 Positive_regulation DUSP9 ANGPT1 24308939 1158457 Positive_regulation DUSP9 ANGPT1 24308939 1158614 Positive_regulation DUSP9 EPHB2 21647446 2527483 Positive_regulation DUSP9 EPHB2 23006971 2181254 Positive_regulation DUT CD14 22566960 900540 Positive_regulation DUX4 FBXO32 22053214 2568073 Positive_regulation DUX4 FBXO32 22053214 2568084 Positive_regulation DVL1 AXIN2 14734535 1305051 Positive_regulation DVL1 F2R PMC2756345 496059 Positive_regulation DVL1 FZD4 22645520 873898 Positive_regulation DVL1 FZD4 23738079 3081174 Positive_regulation DVL1 GPR132 21490931 2512743 Positive_regulation DVL1 WNT7A 23437169 2755894 Positive_regulation DVL1 WNT7A 24105999 702943 Positive_regulation DVL2 AXIN2 14734535 1305055 Positive_regulation DVL2 F2R PMC2756345 496060 Positive_regulation DVL2 FZD4 22645520 873925 Positive_regulation DVL2 FZD4 23738079 3081184 Positive_regulation DVL2 GPR132 21490931 2512745 Positive_regulation DVL3 AXIN2 14734535 1305059 Positive_regulation DVL3 F2R PMC2756345 496061 Positive_regulation DVL3 FZD4 22645520 873952 Positive_regulation DVL3 FZD4 23738079 3081194 Positive_regulation DVL3 GPR132 21490931 2512747 Positive_regulation DYNC1H1 NES 15251038 277797 Positive_regulation DYNC1I2 NES 15251038 277798 Positive_regulation DYNLL1 CLU 19597465 2125642 Positive_regulation DYNLL1 NES 15251038 277764 Positive_regulation DYNLRB1 TNF 23638011 2786960 Positive_regulation DYRK1B CCND1 17407548 1846378 Positive_regulation E2F1 CCND1 10725332 1256810 Positive_regulation E2F1 CCND1 15985168 312893 Positive_regulation E2F1 CCND1 17535444 300086 Positive_regulation E2F1 CCND1 18695042 1354618 Positive_regulation E2F1 CCND1 19823668 2268880 Positive_regulation E2F1 CCND1 19863813 584390 Positive_regulation E2F1 CCND1 21152316 1090430 Positive_regulation E2F1 CCND1 21364958 2504643 Positive_regulation E2F1 CCND1 22541644 3161075 Positive_regulation E2F1 CCND1 22761954 2659529 Positive_regulation E2F1 CCND1 22949827 1097914 Positive_regulation E2F1 CCND1 23440594 1137607 Positive_regulation E2F1 CCND1 24885920 1874622 Positive_regulation E2F1 CCND1 24971481 548963 Positive_regulation E2F1 CCND1 24987693 193651 Positive_regulation E2F1 CCND1 25409181 3028451 Positive_regulation E2F1 CTGF 23902294 344715 Positive_regulation E2F1 CTGF 23902294 344813 Positive_regulation E2F1 CTGF 23902294 344814 Positive_regulation E2F1 EPHB2 23902294 344716 Positive_regulation E2F1 IFI27 21566658 547263 Positive_regulation E2F1 IFI27 24976536 1483660 Positive_regulation E2F1 IFI27 24976536 1483688 Positive_regulation E2F1 UCA1 24876127 758399 Positive_regulation E2F2 CCND1 15985168 312895 Positive_regulation E2F2 CCND1 17535444 300090 Positive_regulation E2F2 CCND1 19823668 2268884 Positive_regulation E2F2 CCND1 19863813 584392 Positive_regulation E2F2 CCND1 21152316 1090431 Positive_regulation E2F2 CCND1 21364958 2504645 Positive_regulation E2F2 CCND1 22541644 3161076 Positive_regulation E2F2 CCND1 22761954 2659533 Positive_regulation E2F2 CCND1 22949827 1097915 Positive_regulation E2F2 CCND1 24885920 1874627 Positive_regulation E2F2 CCND1 24987693 193652 Positive_regulation E2F2 CCND1 25409181 3028453 Positive_regulation E2F3 CCND1 15985168 312897 Positive_regulation E2F3 CCND1 17535444 300094 Positive_regulation E2F3 CCND1 19823668 2268888 Positive_regulation E2F3 CCND1 19863813 584394 Positive_regulation E2F3 CCND1 21152316 1090432 Positive_regulation E2F3 CCND1 21364958 2504647 Positive_regulation E2F3 CCND1 22541644 3161077 Positive_regulation E2F3 CCND1 22761954 2659537 Positive_regulation E2F3 CCND1 22949827 1097916 Positive_regulation E2F3 CCND1 24885920 1874632 Positive_regulation E2F3 CCND1 24987693 193653 Positive_regulation E2F3 CCND1 25409181 3028455 Positive_regulation E2F4 CCND1 10725332 1256811 Positive_regulation E2F4 CCND1 15985168 312899 Positive_regulation E2F4 CCND1 17535444 300098 Positive_regulation E2F4 CCND1 19823668 2268892 Positive_regulation E2F4 CCND1 19863813 584396 Positive_regulation E2F4 CCND1 21152316 1090433 Positive_regulation E2F4 CCND1 21364958 2504649 Positive_regulation E2F4 CCND1 22541644 3161078 Positive_regulation E2F4 CCND1 22761954 2659541 Positive_regulation E2F4 CCND1 22949827 1097917 Positive_regulation E2F4 CCND1 24885920 1874637 Positive_regulation E2F4 CCND1 24987693 193654 Positive_regulation E2F4 CCND1 25409181 3028457 Positive_regulation E2F4 EPHB2 23919615 290065 Positive_regulation E2F4 EPHB2 23919615 290081 Positive_regulation E2F4 MAP2K6 23919615 290071 Positive_regulation E2F5 CCND1 15985168 312901 Positive_regulation E2F5 CCND1 17535444 300102 Positive_regulation E2F5 CCND1 19823668 2268896 Positive_regulation E2F5 CCND1 19863813 584398 Positive_regulation E2F5 CCND1 21152316 1090434 Positive_regulation E2F5 CCND1 21364958 2504651 Positive_regulation E2F5 CCND1 22541644 3161079 Positive_regulation E2F5 CCND1 22761954 2659545 Positive_regulation E2F5 CCND1 22949827 1097918 Positive_regulation E2F5 CCND1 24885920 1874642 Positive_regulation E2F5 CCND1 24987693 193655 Positive_regulation E2F5 CCND1 25409181 3028459 Positive_regulation E2F6 CCND1 15985168 312903 Positive_regulation E2F6 CCND1 17535444 300106 Positive_regulation E2F6 CCND1 19823668 2268900 Positive_regulation E2F6 CCND1 19863813 584400 Positive_regulation E2F6 CCND1 21152316 1090435 Positive_regulation E2F6 CCND1 21364958 2504653 Positive_regulation E2F6 CCND1 22541644 3161080 Positive_regulation E2F6 CCND1 22761954 2659549 Positive_regulation E2F6 CCND1 22949827 1097919 Positive_regulation E2F6 CCND1 24885920 1874647 Positive_regulation E2F6 CCND1 24987693 193656 Positive_regulation E2F6 CCND1 25409181 3028461 Positive_regulation E2F7 CCND1 15985168 312889 Positive_regulation E2F7 CCND1 17535444 300078 Positive_regulation E2F7 CCND1 19823668 2268872 Positive_regulation E2F7 CCND1 19863813 584386 Positive_regulation E2F7 CCND1 21152316 1090428 Positive_regulation E2F7 CCND1 21364958 2504639 Positive_regulation E2F7 CCND1 22541644 3161073 Positive_regulation E2F7 CCND1 22761954 2659521 Positive_regulation E2F7 CCND1 22949827 1097912 Positive_regulation E2F7 CCND1 24885920 1874612 Positive_regulation E2F7 CCND1 24987693 193649 Positive_regulation E2F7 CCND1 25409181 3028447 Positive_regulation E2F8 CCND1 15985168 312891 Positive_regulation E2F8 CCND1 17535444 300082 Positive_regulation E2F8 CCND1 19823668 2268876 Positive_regulation E2F8 CCND1 19863813 584388 Positive_regulation E2F8 CCND1 21152316 1090429 Positive_regulation E2F8 CCND1 21364958 2504641 Positive_regulation E2F8 CCND1 22541644 3161074 Positive_regulation E2F8 CCND1 22761954 2659525 Positive_regulation E2F8 CCND1 22949827 1097913 Positive_regulation E2F8 CCND1 24885920 1874617 Positive_regulation E2F8 CCND1 24987693 193650 Positive_regulation E2F8 CCND1 25409181 3028449 Positive_regulation EBF1 ZFP57 23569325 1571267 Positive_regulation EBI3 TNF 22438968 2612429 Positive_regulation EBI3 TNF 22438968 2612435 Positive_regulation EBI3 TNF 23285065 2732366 Positive_regulation EBP FOXO1 21915332 2553359 Positive_regulation EBR3 COL17A1 23028347 2338279 Positive_regulation EBR4 COL17A1 23028347 2338280 Positive_regulation ECD JAG1 22509166 957029 Positive_regulation ECI1 FOXO1 22997544 2224924 Positive_regulation ECM1 CCND1 11425869 1271739 Positive_regulation ECM1 CD14 19710907 2424818 Positive_regulation ECM1 CD14 23133375 3059957 Positive_regulation ECM1 CTGF 17224075 279450 Positive_regulation ECM1 CTGF 17224075 279451 Positive_regulation ECM1 CTGF 17224075 279460 Positive_regulation ECM1 CTGF 17224075 279466 Positive_regulation ECM1 CTGF 17224075 279468 Positive_regulation ECM1 CTGF 17767742 109035 Positive_regulation ECM1 CTGF 18789696 3190775 Positive_regulation ECM1 CTGF 22329991 1567353 Positive_regulation ECM1 CTGF 22363445 2599072 Positive_regulation ECM1 CTGF 22363445 2599076 Positive_regulation ECM1 CTGF 22363445 2599080 Positive_regulation ECM1 CTGF 22606234 2642435 Positive_regulation ECM1 CTGF 22824096 856045 Positive_regulation ECM1 CTGF 23750089 163598 Positive_regulation ECM1 CTGF 23946690 1716041 Positive_regulation ECM1 CTGF 23946690 1716107 Positive_regulation ECM1 CTGF 23946690 1716130 Positive_regulation ECM1 CTGF 23950936 2832985 Positive_regulation ECM1 CTGF 23950936 2832997 Positive_regulation ECM1 CTGF 24040163 2846065 Positive_regulation ECM1 CTGF 24558600 1154249 Positive_regulation ECM1 CTGF 25121739 2997299 Positive_regulation ECM1 CTGF 25237397 856999 Positive_regulation ECM1 EPHB2 19144181 112499 Positive_regulation ECM1 EPHB2 19144181 112516 Positive_regulation ECM1 EPHB2 23304519 1497003 Positive_regulation ECM1 EPHB2 25553258 82628 Positive_regulation ECM1 FAS 24065163 1730287 Positive_regulation ECM1 LAMB3 22536154 3056431 Positive_regulation ECM1 LAMB3 22536154 3056443 Positive_regulation ECM1 MAP2K6 19144181 112505 Positive_regulation ECM1 MAP2K6 19144181 112522 Positive_regulation ECM1 MMP28 12085210 421654 Positive_regulation ECM1 MMP28 19090960 112163 Positive_regulation ECM1 MMP28 19629173 2290572 Positive_regulation ECM1 MMP28 19849841 302711 Positive_regulation ECM1 MMP28 20140262 2440241 Positive_regulation ECM1 MMP28 20540754 3098373 Positive_regulation ECM1 MMP28 20551596 3078669 Positive_regulation ECM1 MMP28 22363545 2599707 Positive_regulation ECM1 MMP28 22767145 438915 Positive_regulation ECM1 MMP28 22943504 856087 Positive_regulation ECM1 MMP28 22952682 2683613 Positive_regulation ECM1 MMP28 23551430 1480181 Positive_regulation ECM1 MMP28 23586040 181275 Positive_regulation ECM1 MMP28 23798731 1405620 Positive_regulation ECM1 MMP28 23840773 2817389 Positive_regulation ECM1 MMP28 23874933 2823669 Positive_regulation ECM1 MMP28 23991045 2840734 Positive_regulation ECM1 MMP28 24070030 388738 Positive_regulation ECM1 MMP28 24347917 2248295 Positive_regulation ECM1 MMP28 24373218 131202 Positive_regulation ECM1 MMP28 24742302 276051 Positive_regulation ECM1 MMP28 24911051 2977515 Positive_regulation ECM1 MMP28 25545245 3036254 Positive_regulation ECM1 MMP28 8976186 1599621 Positive_regulation ECM1 MMP7 12085210 421669 Positive_regulation ECM1 MMP7 19090960 112178 Positive_regulation ECM1 MMP7 19629173 2290587 Positive_regulation ECM1 MMP7 19849841 302726 Positive_regulation ECM1 MMP7 20140262 2440256 Positive_regulation ECM1 MMP7 20540754 3098388 Positive_regulation ECM1 MMP7 20551596 3078685 Positive_regulation ECM1 MMP7 22363545 2599722 Positive_regulation ECM1 MMP7 22767145 438930 Positive_regulation ECM1 MMP7 22943504 856102 Positive_regulation ECM1 MMP7 22952682 2683628 Positive_regulation ECM1 MMP7 23551430 1480196 Positive_regulation ECM1 MMP7 23586040 181290 Positive_regulation ECM1 MMP7 23798731 1405635 Positive_regulation ECM1 MMP7 23840773 2817404 Positive_regulation ECM1 MMP7 23874933 2823684 Positive_regulation ECM1 MMP7 23991045 2840749 Positive_regulation ECM1 MMP7 24070030 388753 Positive_regulation ECM1 MMP7 24347917 2248310 Positive_regulation ECM1 MMP7 24373218 131217 Positive_regulation ECM1 MMP7 24742302 276066 Positive_regulation ECM1 MMP7 24911051 2977530 Positive_regulation ECM1 MMP7 24978435 504713 Positive_regulation ECM1 MMP7 25545245 3036269 Positive_regulation ECM1 MMP7 8976186 1599636 Positive_regulation ECM1 NPNT 21937601 703081 Positive_regulation ECM1 PLAU 16737540 480384 Positive_regulation ECM1 PLAU 18686734 1071626 Positive_regulation ECM1 PLAU 19820721 8267 Positive_regulation ECM1 PLAU 22131991 1673223 Positive_regulation ECM1 PLAU 23226636 1044346 Positive_regulation ECM1 PLAU 23243599 2161901 Positive_regulation ECM1 PLAU 24129242 442088 Positive_regulation ECM1 PLAU 25222667 1730987 Positive_regulation ECM1 PLAU 25295247 200729 Positive_regulation ECM1 PLAU PMC4041408 745999 Positive_regulation ECM1 SRGN 21880179 623909 Positive_regulation ECM1 TLR7 18612394 2392673 Positive_regulation ECM1 TNF 20843335 1626167 Positive_regulation ECM1 TNF 21189948 1713915 Positive_regulation ECM1 TNF 2199462 1392612 Positive_regulation ECM1 TNF 24312190 2888259 Positive_regulation ECM2 CCND1 11425869 1271740 Positive_regulation ECM2 CD14 19710907 2424819 Positive_regulation ECM2 CD14 23133375 3059958 Positive_regulation ECM2 CTGF 17224075 279452 Positive_regulation ECM2 CTGF 17224075 279453 Positive_regulation ECM2 CTGF 17224075 279461 Positive_regulation ECM2 CTGF 17224075 279467 Positive_regulation ECM2 CTGF 17224075 279469 Positive_regulation ECM2 CTGF 17767742 109038 Positive_regulation ECM2 CTGF 18789696 3190777 Positive_regulation ECM2 CTGF 22329991 1567354 Positive_regulation ECM2 CTGF 22363445 2599073 Positive_regulation ECM2 CTGF 22363445 2599077 Positive_regulation ECM2 CTGF 22363445 2599081 Positive_regulation ECM2 CTGF 22606234 2642436 Positive_regulation ECM2 CTGF 22824096 856048 Positive_regulation ECM2 CTGF 23750089 163599 Positive_regulation ECM2 CTGF 23946690 1716042 Positive_regulation ECM2 CTGF 23946690 1716108 Positive_regulation ECM2 CTGF 23946690 1716131 Positive_regulation ECM2 CTGF 23950936 2832986 Positive_regulation ECM2 CTGF 23950936 2832998 Positive_regulation ECM2 CTGF 24040163 2846066 Positive_regulation ECM2 CTGF 24558600 1154250 Positive_regulation ECM2 CTGF 25121739 2997300 Positive_regulation ECM2 CTGF 25237397 857000 Positive_regulation ECM2 EPHB2 19144181 112507 Positive_regulation ECM2 EPHB2 19144181 112524 Positive_regulation ECM2 EPHB2 23304519 1497007 Positive_regulation ECM2 EPHB2 25553258 82632 Positive_regulation ECM2 FAS 24065163 1730289 Positive_regulation ECM2 LAMB3 22536154 3056434 Positive_regulation ECM2 LAMB3 22536154 3056446 Positive_regulation ECM2 MAP2K6 19144181 112513 Positive_regulation ECM2 MAP2K6 19144181 112530 Positive_regulation ECM2 MMP28 12085210 421676 Positive_regulation ECM2 MMP28 19090960 112185 Positive_regulation ECM2 MMP28 19629173 2290594 Positive_regulation ECM2 MMP28 19849841 302733 Positive_regulation ECM2 MMP28 20140262 2440263 Positive_regulation ECM2 MMP28 20540754 3098395 Positive_regulation ECM2 MMP28 20551596 3078692 Positive_regulation ECM2 MMP28 22363545 2599729 Positive_regulation ECM2 MMP28 22767145 438937 Positive_regulation ECM2 MMP28 22943504 856109 Positive_regulation ECM2 MMP28 22952682 2683635 Positive_regulation ECM2 MMP28 23551430 1480203 Positive_regulation ECM2 MMP28 23586040 181297 Positive_regulation ECM2 MMP28 23798731 1405642 Positive_regulation ECM2 MMP28 23840773 2817411 Positive_regulation ECM2 MMP28 23874933 2823691 Positive_regulation ECM2 MMP28 23991045 2840758 Positive_regulation ECM2 MMP28 24070030 388760 Positive_regulation ECM2 MMP28 24347917 2248317 Positive_regulation ECM2 MMP28 24373218 131224 Positive_regulation ECM2 MMP28 24742302 276073 Positive_regulation ECM2 MMP28 24911051 2977537 Positive_regulation ECM2 MMP28 25545245 3036276 Positive_regulation ECM2 MMP28 8976186 1599643 Positive_regulation ECM2 MMP7 12085210 421691 Positive_regulation ECM2 MMP7 19090960 112200 Positive_regulation ECM2 MMP7 19629173 2290609 Positive_regulation ECM2 MMP7 19849841 302748 Positive_regulation ECM2 MMP7 20140262 2440278 Positive_regulation ECM2 MMP7 20540754 3098410 Positive_regulation ECM2 MMP7 20551596 3078708 Positive_regulation ECM2 MMP7 22363545 2599744 Positive_regulation ECM2 MMP7 22767145 438952 Positive_regulation ECM2 MMP7 22943504 856124 Positive_regulation ECM2 MMP7 22952682 2683650 Positive_regulation ECM2 MMP7 23551430 1480218 Positive_regulation ECM2 MMP7 23586040 181312 Positive_regulation ECM2 MMP7 23798731 1405657 Positive_regulation ECM2 MMP7 23840773 2817426 Positive_regulation ECM2 MMP7 23874933 2823706 Positive_regulation ECM2 MMP7 23991045 2840773 Positive_regulation ECM2 MMP7 24070030 388775 Positive_regulation ECM2 MMP7 24347917 2248332 Positive_regulation ECM2 MMP7 24373218 131239 Positive_regulation ECM2 MMP7 24742302 276088 Positive_regulation ECM2 MMP7 24911051 2977552 Positive_regulation ECM2 MMP7 24978435 504714 Positive_regulation ECM2 MMP7 25545245 3036291 Positive_regulation ECM2 MMP7 8976186 1599658 Positive_regulation ECM2 NPNT 21937601 703082 Positive_regulation ECM2 PLAU 16737540 480385 Positive_regulation ECM2 PLAU 18686734 1071627 Positive_regulation ECM2 PLAU 19820721 8268 Positive_regulation ECM2 PLAU 22131991 1673225 Positive_regulation ECM2 PLAU 23226636 1044347 Positive_regulation ECM2 PLAU 23243599 2161902 Positive_regulation ECM2 PLAU 24129242 442089 Positive_regulation ECM2 PLAU 25222667 1730989 Positive_regulation ECM2 PLAU 25295247 200730 Positive_regulation ECM2 PLAU PMC4041408 746000 Positive_regulation ECM2 SRGN 21880179 623910 Positive_regulation ECM2 TLR7 18612394 2392683 Positive_regulation ECM2 TNF 20843335 1626168 Positive_regulation ECM2 TNF 21189948 1713919 Positive_regulation ECM2 TNF 2199462 1392615 Positive_regulation ECM2 TNF 24312190 2888260 Positive_regulation EDA CCND1 24244705 2881302 Positive_regulation EDA TNF 15946381 3105039 Positive_regulation EDC3 ARSA PMC2268108 1613129 Positive_regulation EDC3 TF 13789454 1528793 Positive_regulation EDC4 ARSA PMC2268108 1613128 Positive_regulation EDC4 TF 13789454 1528792 Positive_regulation EDN1 CTGF 17767742 109026 Positive_regulation EDN1 CTGF 17767742 109042 Positive_regulation EDN1 CTGF 17767742 109043 Positive_regulation EDN1 CTGF 17767742 109056 Positive_regulation EDN1 CTGF 19014648 854650 Positive_regulation EDN1 CTGF 20507556 855038 Positive_regulation EDN1 CTGF 21611193 2523796 Positive_regulation EDN1 CTGF 21941677 1082288 Positive_regulation EDN1 CTGF 22028717 1144833 Positive_regulation EDN1 CTGF 22802915 2219512 Positive_regulation EDN1 CTGF 24015303 2842646 Positive_regulation EDN1 EDN2 21575165 392322 Positive_regulation EDN1 EDN2 8198971 444623 Positive_regulation EDN1 EPHB2 22073262 2569720 Positive_regulation EDN1 FOXO1 24077237 2118286 Positive_regulation EDN1 FOXO1 24494192 3093978 Positive_regulation EDN1 GPNMB 23884103 220660 Positive_regulation EDN1 IL1B 19077312 1727809 Positive_regulation EDN1 MAP2K6 22073262 2569727 Positive_regulation EDN1 MMP28 17767740 108957 Positive_regulation EDN1 MMP7 17767740 108972 Positive_regulation EDN1 RNASE1 21235798 3111904 Positive_regulation EDN1 RNASE7 21235798 3111912 Positive_regulation EDN1 SPHK1 23818902 2119919 Positive_regulation EDN1 TNF 15165288 1694922 Positive_regulation EDN1 TNF 17137491 379205 Positive_regulation EDN1 TNF 17497041 1741464 Positive_regulation EDN1 TNF 18195069 1548376 Positive_regulation EDN1 TNF 18475471 1743847 Positive_regulation EDN1 TNF 18475471 1743848 Positive_regulation EDN1 TNF 18475471 1743849 Positive_regulation EDN1 TNF 18475471 1743850 Positive_regulation EDN1 TNF 18475471 1743858 Positive_regulation EDN1 TNF 18475471 1743886 Positive_regulation EDN1 TNF 18475557 1744320 Positive_regulation EDN1 TNF 23565184 2777066 Positive_regulation EDN1 TNF 24040253 2846236 Positive_regulation EDN1 TNF 24040253 2846238 Positive_regulation EDN1 TNF 24040253 2846247 Positive_regulation EDN1 TNF 24040253 2846249 Positive_regulation EDN1 TNF 24040253 2846251 Positive_regulation EDN1 TNF 24130926 204546 Positive_regulation EDN1 TNF 24395887 1574422 Positive_regulation EDN1 TNF 24395887 1574423 Positive_regulation EDN1 TNF 24395887 1574425 Positive_regulation EDN1 TNF 24557580 1123954 Positive_regulation EDN1 TNF 25610703 1083548 Positive_regulation EDN2 ACE 21085492 2482733 Positive_regulation EDN2 AHSA1 18778461 274673 Positive_regulation EDN2 BMP6 16594992 274386 Positive_regulation EDN2 CNTF 21637858 2526961 Positive_regulation EDN2 CROT 20844572 1911979 Positive_regulation EDN2 CSF2 9687520 1603280 Positive_regulation EDN2 CXCL10 22004287 3112812 Positive_regulation EDN2 CXCL10 22004287 3112826 Positive_regulation EDN2 CXCL10 22004287 3112830 Positive_regulation EDN2 CXCL10 22004287 3112835 Positive_regulation EDN2 CXCL11 22004287 3112813 Positive_regulation EDN2 CXCL9 22004287 3112814 Positive_regulation EDN2 ECE1 10352019 1246644 Positive_regulation EDN2 EDN3 23691268 2225945 Positive_regulation EDN2 EDN3 24040226 2846188 Positive_regulation EDN2 EDNRB 21246034 2492878 Positive_regulation EDN2 EDNRB 24493934 1146035 Positive_regulation EDN2 EDNRB 25210474 1680338 Positive_regulation EDN2 FLOT2 19920963 2234783 Positive_regulation EDN2 GAPDH 24282406 969854 Positive_regulation EDN2 GNAQ 21773036 1690229 Positive_regulation EDN2 GP2 18200808 3208547 Positive_regulation EDN2 GP5 18200808 3208548 Positive_regulation EDN2 GP6 18200808 3208546 Positive_regulation EDN2 GP9 18200808 3208549 Positive_regulation EDN2 HNRNPF 18195069 1548276 Positive_regulation EDN2 HNRNPF 18195069 1548277 Positive_regulation EDN2 HNRNPF 18195069 1548278 Positive_regulation EDN2 HNRNPH1 18195069 1548279 Positive_regulation EDN2 HNRNPH1 18195069 1548280 Positive_regulation EDN2 HNRNPH1 18195069 1548281 Positive_regulation EDN2 IL1A 21477368 3112041 Positive_regulation EDN2 IL3 22838633 649212 Positive_regulation EDN2 IL5 16776669 641095 Positive_regulation EDN2 IL6 18195069 1548379 Positive_regulation EDN2 INS 14668049 830554 Positive_regulation EDN2 JAK2 22128240 1913121 Positive_regulation EDN2 LIF 19693290 1909469 Positive_regulation EDN2 LIF 20454693 1910711 Positive_regulation EDN2 LIF 23469133 2762024 Positive_regulation EDN2 MAPK1 18778461 274675 Positive_regulation EDN2 MAPK10 18778461 274676 Positive_regulation EDN2 MAPK11 18778461 274677 Positive_regulation EDN2 MAPK12 18778461 274678 Positive_regulation EDN2 MAPK13 18778461 274679 Positive_regulation EDN2 MAPK14 18778461 274680 Positive_regulation EDN2 MAPK15 18778461 274674 Positive_regulation EDN2 MAPK3 18778461 274681 Positive_regulation EDN2 MAPK4 18778461 274682 Positive_regulation EDN2 MAPK6 18778461 274683 Positive_regulation EDN2 MAPK7 18778461 274684 Positive_regulation EDN2 MAPK8 18778461 274685 Positive_regulation EDN2 MAPK9 18778461 274686 Positive_regulation EDN2 MET 25356505 1132902 Positive_regulation EDN2 MMP1 17767740 108980 Positive_regulation EDN2 MMP10 17767740 108981 Positive_regulation EDN2 MMP11 17767740 108982 Positive_regulation EDN2 MMP12 17767740 108983 Positive_regulation EDN2 MMP13 17767740 108984 Positive_regulation EDN2 MMP14 17767740 108985 Positive_regulation EDN2 MMP15 17767740 108986 Positive_regulation EDN2 MMP16 17767740 108987 Positive_regulation EDN2 MMP17 17767740 108988 Positive_regulation EDN2 MMP19 17767740 108989 Positive_regulation EDN2 MMP2 17767740 108990 Positive_regulation EDN2 MMP20 17767740 108991 Positive_regulation EDN2 MMP21 17767740 108978 Positive_regulation EDN2 MMP24 17767740 108992 Positive_regulation EDN2 MMP25 17767740 108975 Positive_regulation EDN2 MMP26 17767740 108976 Positive_regulation EDN2 MMP27 17767740 108977 Positive_regulation EDN2 MMP28 17767740 108979 Positive_regulation EDN2 MMP3 17767740 108993 Positive_regulation EDN2 MMP7 17767740 108994 Positive_regulation EDN2 MMP8 17767740 108995 Positive_regulation EDN2 MMP9 17767740 108996 Positive_regulation EDN2 NOS1 17285300 2242431 Positive_regulation EDN2 NOS1 20300455 1214080 Positive_regulation EDN2 PDGFB 8567727 1450398 Positive_regulation EDN2 PGF 14613533 3095528 Positive_regulation EDN2 PTBP1 18195069 1548282 Positive_regulation EDN2 PTBP1 18195069 1548283 Positive_regulation EDN2 PTBP1 18195069 1548284 Positive_regulation EDN2 PTBP2 18195069 1548273 Positive_regulation EDN2 PTBP2 18195069 1548274 Positive_regulation EDN2 PTBP2 18195069 1548275 Positive_regulation EDN2 RNASE1 21235798 3111916 Positive_regulation EDN2 RNASE10 21235798 3111922 Positive_regulation EDN2 RNASE11 21235798 3111921 Positive_regulation EDN2 RNASE12 21235798 3111926 Positive_regulation EDN2 RNASE13 21235798 3111927 Positive_regulation EDN2 RNASE2 21235798 3111917 Positive_regulation EDN2 RNASE3 21235798 3111918 Positive_regulation EDN2 RNASE4 21235798 3111919 Positive_regulation EDN2 RNASE6 21235798 3111920 Positive_regulation EDN2 RNASE7 21235798 3111924 Positive_regulation EDN2 RNASE8 21235798 3111923 Positive_regulation EDN2 RNASE9 21235798 3111925 Positive_regulation EDN2 ROCK1 24489801 2916304 Positive_regulation EDN2 ROCK2 24489801 2916305 Positive_regulation EDN2 RUNX2 20863401 1859304 Positive_regulation EDN2 SETD2 22874467 834879 Positive_regulation EDN2 SETD2 22874467 834880 Positive_regulation EDN2 SETD2 22874467 834881 Positive_regulation EDN2 SETD2 22874467 834884 Positive_regulation EDN2 SETD2 22874467 834885 Positive_regulation EDN2 SLC33A1 24472528 131437 Positive_regulation EDN2 SMARCAD1 20844572 1911978 Positive_regulation EDN2 SOX10 24040226 2846187 Positive_regulation EDN2 STAT1 22128240 1913120 Positive_regulation EDN2 TLR2 20525138 34477 Positive_regulation EDN2 TNF 18195069 1548378 Positive_regulation EDN2 TNF 18475471 1743851 Positive_regulation EDN2 TSLP 22838633 649211 Positive_regulation EDN2 TSLP 22838633 649218 Positive_regulation EDN2 TSLP 22838633 649219 Positive_regulation EDN2 TSLP 22838633 649227 Positive_regulation EDN2 TSPAN31 22291776 95030 Positive_regulation EDN2 VEGFA 24763822 2958447 Positive_regulation EDN2 VEGFA 24763822 2958452 Positive_regulation EDN2 VEGFA 24763822 2958455 Positive_regulation EDN2 VEGFA 24763822 2958457 Positive_regulation EDN3 MMP28 17767740 109001 Positive_regulation EDN3 MMP7 17767740 109016 Positive_regulation EDN3 RNASE1 21235798 3111928 Positive_regulation EDN3 RNASE7 21235798 3111936 Positive_regulation EDN3 TNF 18195069 1548380 Positive_regulation EDN3 TNF 18475471 1743852 Positive_regulation EDNRA EDN2 21808738 1145353 Positive_regulation EDNRA EDN2 25210474 1680341 Positive_regulation EDNRA EDN2 25342915 1140260 Positive_regulation EDNRB EDN2 24493934 1146038 Positive_regulation EDNRB EDN2 24747725 2955892 Positive_regulation EDNRB EDN2 25210474 1680345 Positive_regulation EDNRB EPHB2 25479176 3032198 Positive_regulation EDNRB FHL1 24516350 1085058 Positive_regulation EDNRB MAP2K6 25479176 3032204 Positive_regulation EDNRB TNF 19706169 274907 Positive_regulation EED TNF 24007266 1667012 Positive_regulation EED ZFP57 20808772 2472127 Positive_regulation EEF2K EPHB2 24478645 861074 Positive_regulation EFNA1 EFNB1 19001122 1359697 Positive_regulation EFNA1 EPHB2 19001122 1359699 Positive_regulation EFNA1 PLAU 10648567 1255405 Positive_regulation EFNA1 TNF 20224755 1672020 Positive_regulation EFNA1 TNF 24040255 2846266 Positive_regulation EFNA5 EPHB2 20824214 2474090 Positive_regulation EFNB1 DAB1 23318582 610935 Positive_regulation EFNB1 EFNA1 19001122 1359700 Positive_regulation EFNB1 EFNB1 22934060 958664 Positive_regulation EFNB1 EFNB2 22934060 958665 Positive_regulation EFNB1 EFNB3 22934060 958666 Positive_regulation EFNB1 EPHA1 25247423 2288139 Positive_regulation EFNB1 EPHA10 25247423 2288138 Positive_regulation EFNB1 EPHA2 25247423 2288140 Positive_regulation EFNB1 EPHA3 22144690 1394311 Positive_regulation EFNB1 EPHA3 25247423 2288141 Positive_regulation EFNB1 EPHA4 19001122 1359701 Positive_regulation EFNB1 EPHA4 24130906 2867674 Positive_regulation EFNB1 EPHA4 25247423 2288142 Positive_regulation EFNB1 EPHA5 25247423 2288143 Positive_regulation EFNB1 EPHA6 25247423 2288137 Positive_regulation EFNB1 EPHA7 25247423 2288144 Positive_regulation EFNB1 EPHA8 25247423 2288145 Positive_regulation EFNB1 EPHB1 22934060 958667 Positive_regulation EFNB1 EPHB1 25473648 1713017 Positive_regulation EFNB1 EPHB2 19001122 1359702 Positive_regulation EFNB1 EPHB2 19047466 1362056 Positive_regulation EFNB1 EPHB2 19047466 1362149 Positive_regulation EFNB1 EPHB2 22310282 2146193 Positive_regulation EFNB1 EPHB2 22934060 958668 Positive_regulation EFNB1 EPHB2 23318582 610936 Positive_regulation EFNB1 EPHB2 25473648 1713018 Positive_regulation EFNB1 EPHB3 22934060 958669 Positive_regulation EFNB1 EPHB3 25473648 1713019 Positive_regulation EFNB1 EPHB4 18797510 1084000 Positive_regulation EFNB1 EPHB4 22934060 958670 Positive_regulation EFNB1 EPHB4 25473648 1713020 Positive_regulation EFNB1 EPHB6 22934060 958671 Positive_regulation EFNB1 EPHB6 25473648 1713021 Positive_regulation EFNB1 ERBB2 22279592 2590846 Positive_regulation EFNB1 ERBB2 22279592 2590857 Positive_regulation EFNB1 IFIT2 20565770 360378 Positive_regulation EFNB1 IL1A 20979661 1897736 Positive_regulation EFNB1 IL1A 20979661 1897737 Positive_regulation EFNB1 IL1A 20979661 1897744 Positive_regulation EFNB1 IL1A 20979661 1897747 Positive_regulation EFNB1 MAPK1 23630663 943068 Positive_regulation EFNB1 MAPK3 23630663 943069 Positive_regulation EFNB1 PIK3CA 22879882 2672847 Positive_regulation EFNB1 PIK3R1 22879882 2672848 Positive_regulation EFNB1 PITX2 18541704 1352732 Positive_regulation EFNB1 PTPN13 22279592 2590842 Positive_regulation EFNB1 PTPN13 22279592 2590843 Positive_regulation EFNB1 PTPN13 22279592 2590849 Positive_regulation EFNB1 PTPN13 22279592 2590860 Positive_regulation EFNB1 PTPN13 22279592 2590865 Positive_regulation EFNB1 RGS3 18541704 1352729 Positive_regulation EFNB1 SRC 22279592 2590841 Positive_regulation EFNB1 SRC 22279592 2590845 Positive_regulation EFNB1 SRC 22279592 2590848 Positive_regulation EFNB1 SRC 22279592 2590855 Positive_regulation EFNB1 TYR 20565770 360384 Positive_regulation EFNB2 EPHB2 18694808 2012193 Positive_regulation EFNB2 EPHB2 21059214 1897752 Positive_regulation EFNB2 EPHB2 22310282 2146194 Positive_regulation EFNB2 EPHB2 23593160 2779957 Positive_regulation EFNB2 EPHB2 25473648 1713023 Positive_regulation EFNB3 EPHB2 22310282 2146195 Positive_regulation EFNB3 EPHB2 25473648 1713028 Positive_regulation EFS TNF 11238593 1518999 Positive_regulation EFS TNF 11238593 1519027 Positive_regulation EFS TNF 11238593 1519028 Positive_regulation EFTUD1 KCNK3 23497279 268038 Positive_regulation EGF CAPN8 10402474 1248413 Positive_regulation EGF CAPN8 PMC3329082 3086536 Positive_regulation EGF CAPN8 PMC3329082 3086560 Positive_regulation EGF CAPN8 PMC3329082 3086604 Positive_regulation EGF CCND1 22927910 2680887 Positive_regulation EGF CCND1 22927910 2680888 Positive_regulation EGF CCND1 23259795 1699228 Positive_regulation EGF CCND1 24311896 1755584 Positive_regulation EGF CTGF 22135505 3128241 Positive_regulation EGF EPHB2 11514590 1273901 Positive_regulation EGF EPHB2 11897012 389900 Positive_regulation EGF EPHB2 12204819 791205 Positive_regulation EGF EPHB2 12592371 422191 Positive_regulation EGF EPHB2 16365168 1326431 Positive_regulation EGF EPHB2 17284314 1645190 Positive_regulation EGF EPHB2 17668048 2377278 Positive_regulation EGF EPHB2 18004277 1902371 Positive_regulation EGF EPHB2 18218921 849395 Positive_regulation EGF EPHB2 18762583 1357057 Positive_regulation EGF EPHB2 19383130 525235 Positive_regulation EGF EPHB2 19383130 525237 Positive_regulation EGF EPHB2 20122271 1853399 Positive_regulation EGF EPHB2 20551953 435631 Positive_regulation EGF EPHB2 21364665 550098 Positive_regulation EGF EPHB2 21716849 1239518 Positive_regulation EGF EPHB2 21799663 2294617 Positive_regulation EGF EPHB2 21849472 1793449 Positive_regulation EGF EPHB2 21912543 680185 Positive_regulation EGF EPHB2 22193779 2177138 Positive_regulation EGF EPHB2 22701712 2652215 Positive_regulation EGF EPHB2 22873932 533030 Positive_regulation EGF EPHB2 22927910 2680891 Positive_regulation EGF EPHB2 22984397 2688294 Positive_regulation EGF EPHB2 23028692 2692512 Positive_regulation EGF EPHB2 23162692 3131667 Positive_regulation EGF EPHB2 23162692 3131669 Positive_regulation EGF EPHB2 23434660 1101903 Positive_regulation EGF EPHB2 23637902 2786614 Positive_regulation EGF EPHB2 23805861 343935 Positive_regulation EGF EPHB2 23821666 2090935 Positive_regulation EGF EPHB2 23833655 2165248 Positive_regulation EGF EPHB2 23907581 3136570 Positive_regulation EGF EPHB2 24479521 474447 Positive_regulation EGF EPHB2 24744103 494974 Positive_regulation EGF EPHB2 24916153 399781 Positive_regulation EGF EPHB2 24916153 399907 Positive_regulation EGF EPHB2 25364759 862478 Positive_regulation EGF EPHB2 25421240 1135061 Positive_regulation EGF EPHB2 25514808 3035000 Positive_regulation EGF F2R 11266444 1268636 Positive_regulation EGF HBEGF 19829704 2428763 Positive_regulation EGF HBEGF 23391100 342727 Positive_regulation EGF HBEGF 24396465 2167499 Positive_regulation EGF HBEGF 25344915 2206128 Positive_regulation EGF HBEGF 25364759 862477 Positive_regulation EGF HBEGF 7790364 1441080 Positive_regulation EGF ID1 25028095 1875743 Positive_regulation EGF MAP2K6 22873932 533036 Positive_regulation EGF MMP28 19375502 1731656 Positive_regulation EGF MMP28 21098624 1035532 Positive_regulation EGF MMP28 22346752 3055629 Positive_regulation EGF MMP28 23226927 1751021 Positive_regulation EGF MMP28 25237386 1650988 Positive_regulation EGF MMP7 21098624 1035547 Positive_regulation EGF MMP7 22346752 3055644 Positive_regulation EGF MMP7 23226927 1751036 Positive_regulation EGF MMP7 25237386 1651003 Positive_regulation EGF MUC16 23857061 1108545 Positive_regulation EGF NR2F1 24906407 273642 Positive_regulation EGF NR2F1 24906407 273657 Positive_regulation EGF NR2F1 24906407 273661 Positive_regulation EGF NR2F1 24906407 273667 Positive_regulation EGF S100A7 23300877 2736952 Positive_regulation EGF SPHK1 25309325 871469 Positive_regulation EGF TF 14757755 1305617 Positive_regulation EGF TF 2556406 1423169 Positive_regulation EGFR AGR2 23635006 473254 Positive_regulation EGFR CCND1 19935697 2128211 Positive_regulation EGFR CCND1 19935697 2128327 Positive_regulation EGFR CCND1 22927910 2680990 Positive_regulation EGFR CCND1 24499623 1507698 Positive_regulation EGFR CCND1 24499623 1507758 Positive_regulation EGFR CHI3L1 21274454 1218929 Positive_regulation EGFR CHI3L1 21274454 1218930 Positive_regulation EGFR CTGF 23175185 548165 Positive_regulation EGFR CTGF 23175185 548173 Positive_regulation EGFR CTGF 23175185 548183 Positive_regulation EGFR CTGF 23175185 548190 Positive_regulation EGFR EPHB2 11953870 421538 Positive_regulation EGFR EPHB2 14517202 1298844 Positive_regulation EGFR EPHB2 14623871 1301446 Positive_regulation EGFR EPHB2 19254952 1165611 Positive_regulation EGFR EPHB2 19626123 2421834 Positive_regulation EGFR EPHB2 19861649 505888 Positive_regulation EGFR EPHB2 20122271 1853404 Positive_regulation EGFR EPHB2 20877637 2475432 Positive_regulation EGFR EPHB2 21554739 397977 Positive_regulation EGFR EPHB2 21743488 2140766 Positive_regulation EGFR EPHB2 21927027 2142780 Positive_regulation EGFR EPHB2 22053213 2568067 Positive_regulation EGFR EPHB2 22077956 3091369 Positive_regulation EGFR EPHB2 22649008 778726 Positive_regulation EGFR EPHB2 22675459 2648586 Positive_regulation EGFR EPHB2 22904641 490816 Positive_regulation EGFR EPHB2 22967907 1506567 Positive_regulation EGFR EPHB2 22984397 2688268 Positive_regulation EGFR EPHB2 22988345 1750575 Positive_regulation EGFR EPHB2 23617763 268274 Positive_regulation EGFR EPHB2 23617883 1867926 Positive_regulation EGFR EPHB2 23821666 2090939 Positive_regulation EGFR EPHB2 23942551 728409 Positive_regulation EGFR EPHB2 23991110 2840955 Positive_regulation EGFR EPHB2 24124521 2865984 Positive_regulation EGFR EPHB2 24212818 498619 Positive_regulation EGFR EPHB2 24268047 1481982 Positive_regulation EGFR EPHB2 24304271 682469 Positive_regulation EGFR EPHB2 24655548 245863 Positive_regulation EGFR EPHB2 24763051 574230 Positive_regulation EGFR EPHB2 25356505 1132965 Positive_regulation EGFR EPHB2 25490205 3033046 Positive_regulation EGFR F2R 20723226 257124 Positive_regulation EGFR F2R 20723226 257138 Positive_regulation EGFR F2R 20723226 257140 Positive_regulation EGFR F2R 20723226 257141 Positive_regulation EGFR F2R 24215724 538105 Positive_regulation EGFR F2R 24215724 538106 Positive_regulation EGFR F2R 24215724 538196 Positive_regulation EGFR F2R 24215724 538197 Positive_regulation EGFR F2R 24215724 538198 Positive_regulation EGFR F2R 24215724 538219 Positive_regulation EGFR F2R 24215724 538252 Positive_regulation EGFR F2R 24215724 538297 Positive_regulation EGFR F2R 24385683 1756346 Positive_regulation EGFR F2R 24385683 1756373 Positive_regulation EGFR F2R 24385683 1756402 Positive_regulation EGFR FAS 23050157 1079429 Positive_regulation EGFR FAS 24212818 498634 Positive_regulation EGFR GPR115 11250708 456271 Positive_regulation EGFR GPR115 23451083 2757607 Positive_regulation EGFR GPR132 11250708 456260 Positive_regulation EGFR GPR132 23451083 2757596 Positive_regulation EGFR GPR87 11250708 456340 Positive_regulation EGFR GPR87 23451083 2757676 Positive_regulation EGFR HBEGF 11038170 1263708 Positive_regulation EGFR HBEGF 11250708 456342 Positive_regulation EGFR HBEGF 14597771 1299754 Positive_regulation EGFR HBEGF 14597771 1299851 Positive_regulation EGFR HBEGF 15827558 425505 Positive_regulation EGFR HBEGF 16908672 1332030 Positive_regulation EGFR HBEGF 18404512 3089608 Positive_regulation EGFR HBEGF 18949075 2208059 Positive_regulation EGFR HBEGF 19531065 3187189 Positive_regulation EGFR HBEGF 19574994 7664 Positive_regulation EGFR HBEGF 20139904 9342 Positive_regulation EGFR HBEGF 20195469 2441911 Positive_regulation EGFR HBEGF 20195469 2441963 Positive_regulation EGFR HBEGF 21946538 1961670 Positive_regulation EGFR HBEGF 21946538 1961671 Positive_regulation EGFR HBEGF 21946538 1961672 Positive_regulation EGFR HBEGF 21997136 437933 Positive_regulation EGFR HBEGF 22496644 3056072 Positive_regulation EGFR HBEGF 22747893 1664302 Positive_regulation EGFR HBEGF 23213380 167852 Positive_regulation EGFR HBEGF 23228038 409316 Positive_regulation EGFR HBEGF 23342005 2741605 Positive_regulation EGFR HBEGF 23344022 1100586 Positive_regulation EGFR HBEGF 23451083 2757725 Positive_regulation EGFR HBEGF 23472148 2764232 Positive_regulation EGFR HBEGF 23472148 2764233 Positive_regulation EGFR HBEGF 23589494 1404532 Positive_regulation EGFR HBEGF 23589494 1404533 Positive_regulation EGFR HBEGF 23589494 1404559 Positive_regulation EGFR HBEGF 23888518 3185316 Positive_regulation EGFR HBEGF 23991110 2840950 Positive_regulation EGFR HBEGF 24013225 2153505 Positive_regulation EGFR HBEGF 24013225 2153511 Positive_regulation EGFR HBEGF 24013225 2153513 Positive_regulation EGFR HBEGF 24071938 1112833 Positive_regulation EGFR HBEGF 24132149 1113457 Positive_regulation EGFR HBEGF 24304271 682472 Positive_regulation EGFR HBEGF 24498290 2919123 Positive_regulation EGFR HBEGF 24590763 1575105 Positive_regulation EGFR HBEGF 24952482 2192855 Positive_regulation EGFR HBEGF 25232008 1830860 Positive_regulation EGFR HBEGF 25232008 1830862 Positive_regulation EGFR HBEGF 25249545 2201892 Positive_regulation EGFR HBEGF 25261977 1510577 Positive_regulation EGFR HBEGF 25261977 1510691 Positive_regulation EGFR HBEGF 25356505 1133563 Positive_regulation EGFR HBEGF 25356505 1133622 Positive_regulation EGFR HBEGF 25421240 1135184 Positive_regulation EGFR HBEGF 25437333 2234080 Positive_regulation EGFR HBEGF 25437333 2234088 Positive_regulation EGFR HBEGF PMC3353448 35133 Positive_regulation EGFR HBEGF PMC3760629 1606196 Positive_regulation EGFR ID1 15599381 425166 Positive_regulation EGFR ID1 15599381 425167 Positive_regulation EGFR ID1 15599381 425171 Positive_regulation EGFR ID1 15599381 425174 Positive_regulation EGFR IL1B 22792188 2661284 Positive_regulation EGFR IL1B 23977375 2840165 Positive_regulation EGFR MAP2K6 20877637 2475438 Positive_regulation EGFR MAP2K6 22077956 3091378 Positive_regulation EGFR MAP2K6 23617883 1867934 Positive_regulation EGFR MAP2K6 24807215 1941994 Positive_regulation EGFR MATN2 24691449 2947771 Positive_regulation EGFR MMP28 20139904 9356 Positive_regulation EGFR MMP28 20139904 9403 Positive_regulation EGFR MMP28 21151531 1081347 Positive_regulation EGFR MMP28 22675459 2648633 Positive_regulation EGFR MMP28 22747893 1664250 Positive_regulation EGFR MMP28 22792188 2661452 Positive_regulation EGFR MMP28 23688423 313788 Positive_regulation EGFR MMP28 24132149 1113456 Positive_regulation EGFR MMP28 24215724 538296 Positive_regulation EGFR MMP28 24872356 2252193 Positive_regulation EGFR MMP28 24872356 2252240 Positive_regulation EGFR MMP28 25356505 1132926 Positive_regulation EGFR MMP28 25356505 1132927 Positive_regulation EGFR MMP7 20139904 9373 Positive_regulation EGFR MMP7 20139904 9418 Positive_regulation EGFR MMP7 21151531 1081363 Positive_regulation EGFR MMP7 22246855 1606850 Positive_regulation EGFR MMP7 22675459 2648648 Positive_regulation EGFR MMP7 22747893 1664265 Positive_regulation EGFR MMP7 22792188 2661468 Positive_regulation EGFR MMP7 23688423 313803 Positive_regulation EGFR MMP7 24132149 1113472 Positive_regulation EGFR MMP7 24215724 538313 Positive_regulation EGFR MMP7 24872356 2252209 Positive_regulation EGFR MMP7 24872356 2252255 Positive_regulation EGFR MMP7 25356505 1133050 Positive_regulation EGFR MMP7 25356505 1133051 Positive_regulation EGFR MMP7 25356505 1133052 Positive_regulation EGFR MUC16 21326240 436477 Positive_regulation EGFR MUC16 22701684 2651890 Positive_regulation EGFR MUC16 23319948 1674352 Positive_regulation EGFR NR2F1 24906407 273643 Positive_regulation EGFR NR2F1 24906407 273658 Positive_regulation EGFR NR2F1 24906407 273662 Positive_regulation EGFR PLAT 21576385 1563919 Positive_regulation EGFR PLAU 12556241 1843386 Positive_regulation EGFR PLAU 20868520 1859505 Positive_regulation EGFR PLAU 21822357 1749372 Positive_regulation EGFR PLAU 24340014 2894548 Positive_regulation EGFR PTGER2 22012553 494220 Positive_regulation EGFR PTGER2 22012553 494222 Positive_regulation EGFR RAB31 24265854 655050 Positive_regulation EGFR S100A7 18320059 2384874 Positive_regulation EGFR S100A7 18320059 2384879 Positive_regulation EGFR S100A7 18534028 463007 Positive_regulation EGFR S1PR3 16636149 1329263 Positive_regulation EGFR S1PR3 16636149 1329286 Positive_regulation EGFR S1PR3 16636149 1329323 Positive_regulation EGFR SPHK1 16636149 1329254 Positive_regulation EGFR SPHK1 16636149 1329255 Positive_regulation EGFR SPHK1 16636149 1329256 Positive_regulation EGFR SPHK1 16636149 1329284 Positive_regulation EGFR SPHK1 16636149 1329300 Positive_regulation EGFR SPHK1 16636149 1329301 Positive_regulation EGFR SPHK1 16636149 1329305 Positive_regulation EGFR SPHK1 16636149 1329306 Positive_regulation EGFR SPHK1 16636149 1329349 Positive_regulation EGFR SPHK1 24970177 208687 Positive_regulation EGFR SPHK1 24970177 208688 Positive_regulation EGFR SPHK1 24970177 208702 Positive_regulation EGFR SPHK1 25309325 871470 Positive_regulation EGFR TLR7 20195469 2441852 Positive_regulation EGFR TLR7 20195469 2441906 Positive_regulation EGFR TLR7 20195469 2441927 Positive_regulation EGFR TLR7 20195469 2441980 Positive_regulation EGFR TNF 11686870 3102968 Positive_regulation EGFR TNF 15841081 425525 Positive_regulation EGFR TNF 15841081 425860 Positive_regulation EGFR TNF 15841081 425895 Positive_regulation EGFR TNF 22988345 1750571 Positive_regulation EGFR TNF 22988345 1750574 Positive_regulation EGFR TNF 23389627 1811773 Positive_regulation EGFR TNF 23389627 1811774 Positive_regulation EGFR TNF 23389627 1811881 Positive_regulation EGFR TNF 23389627 1811882 Positive_regulation EGFR TNF 23389627 1811917 Positive_regulation EGFR TNF 23389627 1811957 Positive_regulation EGFR TNF 23651618 3085074 Positive_regulation EGFR TNF 23688423 313783 Positive_regulation EGFR TNF 23688423 314158 Positive_regulation EGFR TNF 23878744 1150842 Positive_regulation EGFR TNF 23905066 3188200 Positive_regulation EGFR TNF 25356505 1132915 Positive_regulation EGFR TNF 25398130 3027511 Positive_regulation EGFR TNF PMC2364207 449992 Positive_regulation EGFR TNFSF10 23840967 1154155 Positive_regulation EGLN1 ANGPT1 18835934 707033 Positive_regulation EGLN1 ANGPT1 18835934 707037 Positive_regulation EGLN1 ANGPT1 23616286 780642 Positive_regulation EGLN1 ANGPT1 24847274 965147 Positive_regulation EGLN2 TNF PMC4212304 3206279 Positive_regulation EGLN3 CDR1 24324362 1084927 Positive_regulation EGLN3 HIF1AN 20967267 2478619 Positive_regulation EGLN3 IFI27 22087251 2570784 Positive_regulation EGLN3 IL13 21464224 1563261 Positive_regulation EGLN3 PPIE 20677832 156741 Positive_regulation EGLN3 PPIE 20677832 156751 Positive_regulation EGLN3 SDHB 22888353 1068793 Positive_regulation EGLN3 SERPINB5 25578879 1879297 Positive_regulation EGLN3 SETD2 19308685 495169 Positive_regulation EGLN3 SETD2 21709315 2176247 Positive_regulation EGLN3 SETD2 24132642 2009001 Positive_regulation EGLN3 SETD2 24386269 2903414 Positive_regulation EGLN3 SETD2 25355043 786933 Positive_regulation EGLN3 SIAH1 18047745 226240 Positive_regulation EGLN3 SIAH1 24809345 2358959 Positive_regulation EGLN3 SIAH1 24809345 2358984 Positive_regulation EGLN3 SIAH2 18047745 226241 Positive_regulation EGLN3 SIAH2 24809345 2358960 Positive_regulation EGLN3 SLC22A3 24367580 2900247 Positive_regulation EGR1 CTGF 23946690 1716124 Positive_regulation EGR1 EPHB2 12177047 1286334 Positive_regulation EGR1 EPHB2 18315872 322360 Positive_regulation EGR1 EPHB2 18615184 3074349 Positive_regulation EGR1 EPHB2 19144181 112413 Positive_regulation EGR1 EPHB2 19144181 112557 Positive_regulation EGR1 EPHB2 19432968 373108 Positive_regulation EGR1 EPHB2 20190820 2129171 Positive_regulation EGR1 EPHB2 20507982 1188027 Positive_regulation EGR1 EPHB2 20827314 979353 Positive_regulation EGR1 EPHB2 21559295 2518082 Positive_regulation EGR1 EPHB2 23109291 779272 Positive_regulation EGR1 EPHB2 23202940 1098708 Positive_regulation EGR1 EPHB2 23284657 2730393 Positive_regulation EGR1 EPHB2 23469182 2762877 Positive_regulation EGR1 EPHB2 23482441 2162225 Positive_regulation EGR1 EPHB2 24023725 2843407 Positive_regulation EGR1 EPHB2 24089634 1160601 Positive_regulation EGR1 EPHB2 25004251 2195431 Positive_regulation EGR1 EPHB2 25004251 2195467 Positive_regulation EGR1 EPHB2 25004251 2195481 Positive_regulation EGR1 EPHB2 25243776 3008755 Positive_regulation EGR1 F3 23535544 3134656 Positive_regulation EGR1 IL1B 22792188 2661256 Positive_regulation EGR1 IL1B 22792188 2661291 Positive_regulation EGR1 IL1B 22792188 2661350 Positive_regulation EGR1 IL1B 22792188 2661351 Positive_regulation EGR1 IL1B 22792188 2661352 Positive_regulation EGR1 IL1B 22792188 2661434 Positive_regulation EGR1 IL1B 22792188 2661435 Positive_regulation EGR1 IL1B 22792188 2661436 Positive_regulation EGR1 IL1B 22792188 2661447 Positive_regulation EGR1 IL1B 23304166 3173806 Positive_regulation EGR1 LGALS7B 23658821 2790333 Positive_regulation EGR1 MAP2K6 19144181 112421 Positive_regulation EGR1 MAP2K6 19144181 112564 Positive_regulation EGR1 MAP2K6 19390590 2414904 Positive_regulation EGR1 MAP2K6 20190820 2129182 Positive_regulation EGR1 MAP2K6 20190820 2129183 Positive_regulation EGR1 MAP2K6 20663135 256857 Positive_regulation EGR1 MAP2K6 21109534 2059074 Positive_regulation EGR1 MAP2K6 22792188 2661442 Positive_regulation EGR1 MAP2K6 23202940 1098714 Positive_regulation EGR1 MMP28 22792188 2661302 Positive_regulation EGR1 MMP28 22792188 2661303 Positive_regulation EGR1 MMP7 22792188 2661383 Positive_regulation EGR1 MMP7 22792188 2661384 Positive_regulation EGR1 TLR7 19997504 3045757 Positive_regulation EGR1 TLR7 20862390 979540 Positive_regulation EGR1 TNF 15142264 101183 Positive_regulation EGR1 TNF 21619646 3214114 Positive_regulation EGR1 TNF 21736731 1898338 Positive_regulation EGR1 TNF 21736731 1898351 Positive_regulation EGR1 TNF 22455954 125291 Positive_regulation EGR1 TNF 25502753 3033877 Positive_regulation EGR1 TNF 9053449 1600191 Positive_regulation EGR1 TNFSF10 20087343 434328 Positive_regulation EGR2 EPHB2 22049075 1193848 Positive_regulation EGR2 MAP2K6 22049075 1193777 Positive_regulation EGR2 ZBTB16 22306690 1956562 Positive_regulation EHF TLR7 23185370 2720170 Positive_regulation EHMT2 ANKRD1 25478012 803886 Positive_regulation EIF2AK2 ABCA4 23638202 2371864 Positive_regulation EIF2AK2 ABCA4 23638202 2371865 Positive_regulation EIF2AK2 ABCA4 23638202 2371866 Positive_regulation EIF2AK2 ABCA4 23638202 2371867 Positive_regulation EIF2AK2 ABCA4 23638202 2371868 Positive_regulation EIF2AK2 ABCA4 23638202 2371869 Positive_regulation EIF2AK2 FAS 22174754 2581085 Positive_regulation EIF2AK2 FAS 25196936 1730945 Positive_regulation EIF2AK2 TLR7 20976225 2479509 Positive_regulation EIF2AK2 TLR7 20976225 2479551 Positive_regulation EIF2AK2 TNF 14979937 100124 Positive_regulation EIF2AK2 TNF 14979937 100178 Positive_regulation EIF2AK2 TNF 23990781 3063836 Positive_regulation EIF2AK2 TP63 23497334 3113553 Positive_regulation EIF3F FBXO32 20126553 2439295 Positive_regulation EIF3F FBXO32 20126553 2439304 Positive_regulation EIF3F FBXO32 23268536 740174 Positive_regulation EIF3F FBXO32 23354061 605334 Positive_regulation EIF3F FBXO32 23354061 605335 Positive_regulation EIF3F FBXO32 23354061 605349 Positive_regulation EIF3F FBXO32 23665154 1054170 Positive_regulation EIF3K KRT38 22590572 2641618 Positive_regulation EIF4E CAPN8 15908588 2016465 Positive_regulation EIF4E EPHB2 22122896 1704119 Positive_regulation EIF4E EPHB2 22122896 1704124 Positive_regulation EIF4E EPHB2 22267161 1967397 Positive_regulation EIF4E EPHB2 22319481 860825 Positive_regulation EIF4E TLR7 22610140 1957323 Positive_regulation EIF4E TNF 1658188 1539828 Positive_regulation EIF4EBP1 EPHB2 16255777 1695463 Positive_regulation EIF4EBP1 EPHB2 22530122 2009483 Positive_regulation EIF4EBP1 FOXO1 23614736 830013 Positive_regulation EIF4EBP1 FOXO1 24982916 193600 Positive_regulation EIF4EBP1 MAP2K6 16255777 1695469 Positive_regulation EIF4EBP1 MAP2K6 24339963 2894434 Positive_regulation EIF4G1 RNASE1 18490513 1352342 Positive_regulation EIF4G2 EPHB2 11425867 1271711 Positive_regulation EIF4G2 RNASE1 18490513 1352343 Positive_regulation EIF4G3 RNASE1 18490513 1352344 Positive_regulation EIF5A MAP2K6 23638878 1868042 Positive_regulation ELANE F2R 21209875 2491648 Positive_regulation ELAVL1 EPHB2 22879928 2673133 Positive_regulation ELAVL1 EPHB2 23840699 2816154 Positive_regulation ELAVL1 ITGAL 21206905 2491145 Positive_regulation ELAVL1 ITGAL 21206905 2491146 Positive_regulation ELAVL1 ITGAL 21206905 2491158 Positive_regulation ELAVL1 ITGAL 21206905 2491194 Positive_regulation ELAVL1 ITGAL 21206905 2491197 Positive_regulation ELAVL1 ITGB2 21206905 2491097 Positive_regulation ELAVL1 ITGB2 21206905 2491136 Positive_regulation ELAVL1 ITGB2 21206905 2491147 Positive_regulation ELAVL1 ITGB2 21206905 2491199 Positive_regulation ELAVL1 ITGB2 21206905 2491200 Positive_regulation ELK1 EPHB2 11309409 1269494 Positive_regulation ELK1 EPHB2 11309409 1269499 Positive_regulation ELK1 EPHB2 19432968 373109 Positive_regulation ELK1 EPHB2 21441990 936215 Positive_regulation ELK1 EPHB2 21441990 936235 Positive_regulation ELK1 EPHB2 21441990 936239 Positive_regulation ELK1 EPHB2 21441990 936245 Positive_regulation ELK1 EPHB2 21655091 2324687 Positive_regulation ELK1 EPHB2 23158473 1867277 Positive_regulation ELK1 EPHB2 23202940 1098725 Positive_regulation ELK1 EPHB2 23823477 590346 Positive_regulation ELK1 EPHB2 24145797 786330 Positive_regulation ELK1 EPHB2 25514431 3034547 Positive_regulation ELK1 EPHB2 25569773 2368071 Positive_regulation ELK1 IFI27 18069898 2304642 Positive_regulation ELK4 EPHB2 12204819 791198 Positive_regulation ELL CAPN8 24430868 1820485 Positive_regulation ELL CCND1 23786849 473335 Positive_regulation ELL CHI3L1 22238378 2071476 Positive_regulation ELL CHI3L1 22238378 2071486 Positive_regulation ELL CHI3L1 22238378 2071487 Positive_regulation ELL CHI3L1 22238378 2071489 Positive_regulation ELL CHI3L1 22238378 2071491 Positive_regulation ELL ELOVL4 21139992 1912420 Positive_regulation ELL ELOVL4 24569140 1637947 Positive_regulation ELL ELOVL4 24569140 1637948 Positive_regulation ELL ELOVL4 24569140 1637953 Positive_regulation ELL ELOVL4 24571530 361214 Positive_regulation ELL EPHB2 23741474 2801184 Positive_regulation ELL EPHB2 23741474 2801185 Positive_regulation ELL EPHB2 24260264 2883566 Positive_regulation ELL EPHB2 24444792 1881663 Positive_regulation ELL EPHB2 24587210 2929063 Positive_regulation ELL FAS 23409096 2753511 Positive_regulation ELL FOXO1 19555482 235796 Positive_regulation ELL GAB3 21217643 768929 Positive_regulation ELL ITGAL 22711877 1568392 Positive_regulation ELL ITGAL 22711877 1568393 Positive_regulation ELL ITGAL 22711877 1568399 Positive_regulation ELL KRT38 23565276 2777722 Positive_regulation ELL MAP2K6 24260264 2883575 Positive_regulation ELL MAP2K6 24444792 1881669 Positive_regulation ELL MAP2K6 24649261 1884437 Positive_regulation ELL MMP28 12975354 1297292 Positive_regulation ELL MMP28 25368556 934428 Positive_regulation ELL MMP7 12975354 1297307 Positive_regulation ELL MMP7 25368556 934443 Positive_regulation ELL MYH3 20948626 846399 Positive_regulation ELL NGFR 20156358 402376 Positive_regulation ELL NR2F1 25610373 872965 Positive_regulation ELL PGC 18974884 2399755 Positive_regulation ELL SARM1 21555464 1386913 Positive_regulation ELL SARM1 21555464 1386920 Positive_regulation ELL SARM1 25221470 939089 Positive_regulation ELL SMN2 25105137 195929 Positive_regulation ELL SRGN 20032306 1772592 Positive_regulation ELL SRGN 20032306 1772618 Positive_regulation ELL TMOD1 20737540 694951 Positive_regulation ELL TMOD1 22013379 1222803 Positive_regulation ELL TMOD1 7798317 1441669 Positive_regulation ELL TNF 20308428 1373847 Positive_regulation ELL TNF 20308428 1373854 Positive_regulation ELL TNF 22391038 1396092 Positive_regulation ELL TNF 22615129 1568236 Positive_regulation ELL TNF 22991685 1082684 Positive_regulation ELL TNF 23789107 169948 Positive_regulation ELL TNF 24205293 2875915 Positive_regulation ELL WNT7A 24167472 931336 Positive_regulation ELN CTGF 20205862 397082 Positive_regulation ELN MMP28 24946848 1087468 Positive_regulation ELN MMP7 24946848 1087483 Positive_regulation ELOVL4 CERS3 23826266 2811874 Positive_regulation ELOVL4 CERS3 23826266 2811878 Positive_regulation ELOVL4 HSD17B12 25003994 2987213 Positive_regulation EML4 EPHB2 24715763 2249894 Positive_regulation EMP1 MYC 16163395 2302026 Positive_regulation EMP1 MYC 20840765 257340 Positive_regulation EMP1 PON1 PMC2377328 2003557 Positive_regulation EMP1 SERPINA1 24743137 2954837 Positive_regulation EMP1 TMEM173 7490292 1435124 Positive_regulation EMP1 TNF 21966220 3209114 Positive_regulation EMP1 TNF 21966220 3209115 Positive_regulation EMP1 TNF 21966220 3209145 Positive_regulation EMP1 TNF 21966220 3209146 Positive_regulation EMP2 TNF 21966220 3209116 Positive_regulation EMP2 TNF 21966220 3209117 Positive_regulation EMP2 TNF 21966220 3209147 Positive_regulation EMP2 TNF 21966220 3209148 Positive_regulation EMP3 TNF 21966220 3209118 Positive_regulation EMP3 TNF 21966220 3209119 Positive_regulation EMP3 TNF 21966220 3209149 Positive_regulation EMP3 TNF 21966220 3209150 Positive_regulation EMR1 RGS2 21179467 2488190 Positive_regulation EMX2 NR2F1 20862356 2291765 Positive_regulation EN1 FOXA1 25249938 871286 Positive_regulation ENG CEACAM6 16115956 1323392 Positive_regulation ENG CEACAM6 24735478 540381 Positive_regulation ENG CEACAM6 PMC2254950 1477062 Positive_regulation ENG NES 24073285 2853657 Positive_regulation ENO1 CCND1 24884804 1874323 Positive_regulation ENO2 CCND1 24884804 1874325 Positive_regulation ENO2 EPHB2 15219238 523855 Positive_regulation ENO3 CCND1 24884804 1874327 Positive_regulation ENO4 CCND1 24884804 1874321 Positive_regulation ENPEP EPHB2 24499932 2299553 Positive_regulation ENPP1 FGF2 19247458 1909007 Positive_regulation ENPP1 INS 21573217 2522974 Positive_regulation ENPP1 SOST 25260930 413135 Positive_regulation ENPP2 IL1B 25049907 136659 Positive_regulation ENPP2 TNF 20356387 1853837 Positive_regulation ENPP2 TNF 20356387 1853840 Positive_regulation ENPP2 TNF 21765444 13140 Positive_regulation ENPP2 TNF 21765444 13141 Positive_regulation ENPP2 TNF 21765444 13147 Positive_regulation ENTPD1 NT5E 23897810 1207977 Positive_regulation ENTPD8 CA2 18404480 3087810 Positive_regulation ENTPD8 CA2 18404510 3089567 Positive_regulation EPC1 EPHB2 24755675 2957231 Positive_regulation EPC1 EPHB2 25268972 3011818 Positive_regulation EPC1 ID1 24620998 132061 Positive_regulation EPC2 EPHB2 24755675 2957235 Positive_regulation EPC2 EPHB2 25268972 3011825 Positive_regulation EPC2 ID1 24620998 132062 Positive_regulation EPCAM CCND1 24940735 2980717 Positive_regulation EPCAM TNF 24692847 1757852 Positive_regulation EPCAM TNF 24692847 1757855 Positive_regulation EPHA1 EFNB1 20824214 2474096 Positive_regulation EPHA1 EFNB1 25247423 2288155 Positive_regulation EPHA10 EFNB1 20824214 2474085 Positive_regulation EPHA10 EFNB1 25247423 2288135 Positive_regulation EPHA2 EFNB1 20824214 2474104 Positive_regulation EPHA2 EFNB1 25247423 2288157 Positive_regulation EPHA2 MMP28 24690323 540200 Positive_regulation EPHA2 MMP7 24690323 540215 Positive_regulation EPHA3 EFNB1 20824214 2474112 Positive_regulation EPHA3 EFNB1 22144690 1394359 Positive_regulation EPHA3 EFNB1 22144690 1394360 Positive_regulation EPHA3 EFNB1 22144690 1394361 Positive_regulation EPHA3 EFNB1 22144690 1394364 Positive_regulation EPHA3 EFNB1 25247423 2288159 Positive_regulation EPHA3 EPHB2 22144690 1394309 Positive_regulation EPHA3 IFI27 18422703 608048 Positive_regulation EPHA3 MIP 20846396 353608 Positive_regulation EPHA3 TLR7 20161797 2440896 Positive_regulation EPHA3 TNF 21115689 1562100 Positive_regulation EPHA3 TNF 21115689 1562131 Positive_regulation EPHA3 TNF 21800856 1651478 Positive_regulation EPHA3 TNF 24130812 2867008 Positive_regulation EPHA3 TNF 24130812 2867009 Positive_regulation EPHA3 TNF 24130812 2867010 Positive_regulation EPHA3 TNF 24467387 1651481 Positive_regulation EPHA4 EFNB1 19001122 1359704 Positive_regulation EPHA4 EFNB1 20824214 2474120 Positive_regulation EPHA4 EFNB1 24130906 2867675 Positive_regulation EPHA4 EFNB1 25247423 2288123 Positive_regulation EPHA4 EFNB1 25247423 2288161 Positive_regulation EPHA4 EFNB1 25247423 2288179 Positive_regulation EPHA4 EPHB2 19001122 1359705 Positive_regulation EPHA4 MMP28 19414612 1365875 Positive_regulation EPHA4 MMP28 19414612 1365902 Positive_regulation EPHA4 MMP28 19414612 1365926 Positive_regulation EPHA4 MMP7 19414612 1365890 Positive_regulation EPHA4 MMP7 19414612 1365917 Positive_regulation EPHA4 MMP7 19414612 1365941 Positive_regulation EPHA5 EFNB1 20824214 2474129 Positive_regulation EPHA5 EFNB1 25247423 2288163 Positive_regulation EPHA5 EPHB2 20824214 2474133 Positive_regulation EPHA6 EFNB1 20824214 2474077 Positive_regulation EPHA6 EFNB1 25247423 2288133 Positive_regulation EPHA7 EFNB1 20824214 2474139 Positive_regulation EPHA7 EFNB1 25247423 2288165 Positive_regulation EPHA8 EFNB1 20824214 2474147 Positive_regulation EPHA8 EFNB1 25247423 2288167 Positive_regulation EPHA8 RINL 22291991 2591616 Positive_regulation EPHA8 RINL 22291991 2591639 Positive_regulation EPHB1 EFNB1 19025592 1897125 Positive_regulation EPHB1 EFNB1 20824214 2474156 Positive_regulation EPHB1 EFNB1 21390298 2275252 Positive_regulation EPHB1 EFNB1 23143520 1967844 Positive_regulation EPHB1 EFNB1 25473648 1713032 Positive_regulation EPHB1 EPHB2 20824214 2474160 Positive_regulation EPHB1 EPHB2 21847105 1933281 Positive_regulation EPHB2 ABCA4 14676298 1530157 Positive_regulation EPHB2 ABCA4 14676298 1530158 Positive_regulation EPHB2 ABCC8 20549726 701641 Positive_regulation EPHB2 ABCC8 23932869 1065708 Positive_regulation EPHB2 ABL1 16009726 1321442 Positive_regulation EPHB2 ABL1 19829692 2428665 Positive_regulation EPHB2 ABL1 21979943 739125 Positive_regulation EPHB2 ABL1 24155950 2871734 Positive_regulation EPHB2 ACD 15026815 424437 Positive_regulation EPHB2 ACD 19137382 621167 Positive_regulation EPHB2 ACD 19804630 401975 Positive_regulation EPHB2 ACD 25118589 1944698 Positive_regulation EPHB2 ACD 25629002 949883 Positive_regulation EPHB2 ACE 24737988 3156483 Positive_regulation EPHB2 ACKR3 21655198 2527628 Positive_regulation EPHB2 ACKR3 21655198 2527635 Positive_regulation EPHB2 ACKR3 22472349 1698245 Positive_regulation EPHB2 ACKR3 22472349 1698248 Positive_regulation EPHB2 ACKR3 22472349 1698254 Positive_regulation EPHB2 ACKR3 24886617 474989 Positive_regulation EPHB2 ACO2 21887333 2549330 Positive_regulation EPHB2 ACP2 21998736 2562286 Positive_regulation EPHB2 ACP2 21998736 2562304 Positive_regulation EPHB2 ACP2 21998736 2562305 Positive_regulation EPHB2 ADAM17 23389627 1811784 Positive_regulation EPHB2 ADAM17 23389627 1811946 Positive_regulation EPHB2 ADAM17 23389627 1811964 Positive_regulation EPHB2 ADAM17 23942551 728411 Positive_regulation EPHB2 ADAM17 24097797 1034411 Positive_regulation EPHB2 ADCY2 21254404 775848 Positive_regulation EPHB2 ADCYAP1 20062533 2436710 Positive_regulation EPHB2 ADCYAP1 20093365 1168962 Positive_regulation EPHB2 ADI1 23933651 18443 Positive_regulation EPHB2 ADIPOQ 21390243 1049770 Positive_regulation EPHB2 ADIPOQ 21829524 2541605 Positive_regulation EPHB2 ADIPOQ 23424645 2755046 Positive_regulation EPHB2 ADIPOQ 23424645 2755070 Positive_regulation EPHB2 ADIPOQ 23424645 2755071 Positive_regulation EPHB2 ADIPOQ 23424645 2755073 Positive_regulation EPHB2 ADIPOQ 25051362 2196751 Positive_regulation EPHB2 ADM 23440494 2171271 Positive_regulation EPHB2 ADORA2B 18947405 361913 Positive_regulation EPHB2 ADRBK1 23977191 2838873 Positive_regulation EPHB2 ADRBK1 24597858 1650556 Positive_regulation EPHB2 AGA 21317295 717825 Positive_regulation EPHB2 AGA 21317295 717826 Positive_regulation EPHB2 AGK 15939762 1320796 Positive_regulation EPHB2 AGTR1 20814573 2473472 Positive_regulation EPHB2 AGTR1 20814573 2473478 Positive_regulation EPHB2 AGTR1 20886089 2476257 Positive_regulation EPHB2 AGTR1 20886089 2476270 Positive_regulation EPHB2 AGTR1 25473211 1636246 Positive_regulation EPHB2 AGTR2 24340072 2894832 Positive_regulation EPHB2 AGTR2 24827991 2969923 Positive_regulation EPHB2 AHSA1 17425807 320191 Positive_regulation EPHB2 AHSA1 17425807 320192 Positive_regulation EPHB2 AHSA1 22124112 1566320 Positive_regulation EPHB2 AHSA1 23389627 1811944 Positive_regulation EPHB2 AHSA1 23776632 2805340 Positive_regulation EPHB2 AHSA1 24008724 1142102 Positive_regulation EPHB2 AHSA1 25289117 1636387 Positive_regulation EPHB2 AHSA1 25360677 3021145 Positive_regulation EPHB2 AHSA1 25374757 82620 Positive_regulation EPHB2 AIP 25245034 541120 Positive_regulation EPHB2 AIRE 21364986 2504703 Positive_regulation EPHB2 AIRE 21364986 2504724 Positive_regulation EPHB2 AIRE 21364986 2504750 Positive_regulation EPHB2 AIRE 21364986 2504799 Positive_regulation EPHB2 AKT1 16365168 1326400 Positive_regulation EPHB2 AKT1 16365168 1326401 Positive_regulation EPHB2 AKT1 18159242 2381579 Positive_regulation EPHB2 AKT1 18852899 2397600 Positive_regulation EPHB2 AKT1 19039330 545804 Positive_regulation EPHB2 AKT1 20042122 1852839 Positive_regulation EPHB2 AKT1 20520761 2451861 Positive_regulation EPHB2 AKT1 20520761 2451878 Positive_regulation EPHB2 AKT1 20652960 3170729 Positive_regulation EPHB2 AKT1 20661223 2133164 Positive_regulation EPHB2 AKT1 20977782 3168090 Positive_regulation EPHB2 AKT1 21311715 2502476 Positive_regulation EPHB2 AKT1 21559368 2518949 Positive_regulation EPHB2 AKT1 22116303 438043 Positive_regulation EPHB2 AKT1 22118662 1864283 Positive_regulation EPHB2 AKT1 22159814 1140712 Positive_regulation EPHB2 AKT1 22649371 874785 Positive_regulation EPHB2 AKT1 22649371 874944 Positive_regulation EPHB2 AKT1 22649371 874945 Positive_regulation EPHB2 AKT1 22802915 2219536 Positive_regulation EPHB2 AKT1 23162692 3131681 Positive_regulation EPHB2 AKT1 23320105 2739635 Positive_regulation EPHB2 AKT1 23345981 3177033 Positive_regulation EPHB2 AKT1 23420122 2163409 Positive_regulation EPHB2 AKT1 23591770 3135514 Positive_regulation EPHB2 AKT1 23690850 818983 Positive_regulation EPHB2 AKT1 23700479 2796264 Positive_regulation EPHB2 AKT1 23874982 2823956 Positive_regulation EPHB2 AKT1 24065093 1112684 Positive_regulation EPHB2 AKT1 24116164 2865620 Positive_regulation EPHB2 AKT1 24131623 270093 Positive_regulation EPHB2 AKT1 24265816 2885235 Positive_regulation EPHB2 AKT1 24321545 410804 Positive_regulation EPHB2 AKT1 24520260 844109 Positive_regulation EPHB2 AKT1 24533454 271665 Positive_regulation EPHB2 AKT1 24575365 20590 Positive_regulation EPHB2 AKT1 24619402 2245277 Positive_regulation EPHB2 AKT1 24721622 1679077 Positive_regulation EPHB2 AKT1 24739440 1679362 Positive_regulation EPHB2 AKT1 24744103 495044 Positive_regulation EPHB2 AKT1 24957684 2232006 Positive_regulation EPHB2 AKT1 25268615 1131263 Positive_regulation EPHB2 AKT1 25554259 1736361 Positive_regulation EPHB2 AKT2 18159242 2381580 Positive_regulation EPHB2 AKT2 18852899 2397601 Positive_regulation EPHB2 AKT2 19039330 545805 Positive_regulation EPHB2 AKT2 20042122 1852840 Positive_regulation EPHB2 AKT2 20520761 2451862 Positive_regulation EPHB2 AKT2 20520761 2451879 Positive_regulation EPHB2 AKT2 20652960 3170730 Positive_regulation EPHB2 AKT2 20661223 2133165 Positive_regulation EPHB2 AKT2 20977782 3168091 Positive_regulation EPHB2 AKT2 21297943 2498607 Positive_regulation EPHB2 AKT2 21311715 2502477 Positive_regulation EPHB2 AKT2 21559368 2518950 Positive_regulation EPHB2 AKT2 22116303 438044 Positive_regulation EPHB2 AKT2 22118662 1864284 Positive_regulation EPHB2 AKT2 22159814 1140713 Positive_regulation EPHB2 AKT2 22649371 874786 Positive_regulation EPHB2 AKT2 22649371 874946 Positive_regulation EPHB2 AKT2 22649371 874947 Positive_regulation EPHB2 AKT2 22802915 2219537 Positive_regulation EPHB2 AKT2 23162692 3131682 Positive_regulation EPHB2 AKT2 23320105 2739636 Positive_regulation EPHB2 AKT2 23345981 3177034 Positive_regulation EPHB2 AKT2 23420122 2163410 Positive_regulation EPHB2 AKT2 23591770 3135515 Positive_regulation EPHB2 AKT2 23690850 818984 Positive_regulation EPHB2 AKT2 23700479 2796265 Positive_regulation EPHB2 AKT2 23874982 2823957 Positive_regulation EPHB2 AKT2 24065093 1112685 Positive_regulation EPHB2 AKT2 24116164 2865621 Positive_regulation EPHB2 AKT2 24131623 270094 Positive_regulation EPHB2 AKT2 24265816 2885236 Positive_regulation EPHB2 AKT2 24321545 410805 Positive_regulation EPHB2 AKT2 24520260 844110 Positive_regulation EPHB2 AKT2 24533454 271666 Positive_regulation EPHB2 AKT2 24575365 20591 Positive_regulation EPHB2 AKT2 24619402 2245278 Positive_regulation EPHB2 AKT2 24721622 1679078 Positive_regulation EPHB2 AKT2 24739440 1679363 Positive_regulation EPHB2 AKT2 24744103 495045 Positive_regulation EPHB2 AKT2 24957684 2232007 Positive_regulation EPHB2 AKT2 25268615 1131264 Positive_regulation EPHB2 AKT2 25554259 1736362 Positive_regulation EPHB2 AKT3 18159242 2381581 Positive_regulation EPHB2 AKT3 18852899 2397602 Positive_regulation EPHB2 AKT3 19039330 545806 Positive_regulation EPHB2 AKT3 20042122 1852841 Positive_regulation EPHB2 AKT3 20520761 2451863 Positive_regulation EPHB2 AKT3 20520761 2451880 Positive_regulation EPHB2 AKT3 20652960 3170731 Positive_regulation EPHB2 AKT3 20661223 2133166 Positive_regulation EPHB2 AKT3 20977782 3168092 Positive_regulation EPHB2 AKT3 21311715 2502478 Positive_regulation EPHB2 AKT3 21559368 2518951 Positive_regulation EPHB2 AKT3 22116303 438045 Positive_regulation EPHB2 AKT3 22118662 1864285 Positive_regulation EPHB2 AKT3 22159814 1140714 Positive_regulation EPHB2 AKT3 22649371 874787 Positive_regulation EPHB2 AKT3 22649371 874948 Positive_regulation EPHB2 AKT3 22649371 874949 Positive_regulation EPHB2 AKT3 22802915 2219538 Positive_regulation EPHB2 AKT3 23162692 3131683 Positive_regulation EPHB2 AKT3 23320105 2739637 Positive_regulation EPHB2 AKT3 23345981 3177035 Positive_regulation EPHB2 AKT3 23420122 2163411 Positive_regulation EPHB2 AKT3 23591770 3135516 Positive_regulation EPHB2 AKT3 23690850 818985 Positive_regulation EPHB2 AKT3 23700479 2796266 Positive_regulation EPHB2 AKT3 23874982 2823958 Positive_regulation EPHB2 AKT3 24065093 1112686 Positive_regulation EPHB2 AKT3 24116164 2865622 Positive_regulation EPHB2 AKT3 24131623 270095 Positive_regulation EPHB2 AKT3 24265816 2885237 Positive_regulation EPHB2 AKT3 24321545 410806 Positive_regulation EPHB2 AKT3 24520260 844111 Positive_regulation EPHB2 AKT3 24533454 271667 Positive_regulation EPHB2 AKT3 24575365 20592 Positive_regulation EPHB2 AKT3 24619402 2245279 Positive_regulation EPHB2 AKT3 24721622 1679079 Positive_regulation EPHB2 AKT3 24739440 1679364 Positive_regulation EPHB2 AKT3 24744103 495046 Positive_regulation EPHB2 AKT3 24957684 2232008 Positive_regulation EPHB2 AKT3 25268615 1131265 Positive_regulation EPHB2 AKT3 25554259 1736363 Positive_regulation EPHB2 ALB 21042558 1912079 Positive_regulation EPHB2 ALB 21042558 1912092 Positive_regulation EPHB2 ALB 22507553 1661679 Positive_regulation EPHB2 ALK 21799923 2539208 Positive_regulation EPHB2 ALK 22852078 1689202 Positive_regulation EPHB2 ALK 22928112 155591 Positive_regulation EPHB2 ALK 24281085 501636 Positive_regulation EPHB2 ALK 25380037 3023901 Positive_regulation EPHB2 ALOX5 25025775 2989408 Positive_regulation EPHB2 AMH 23853725 1153311 Positive_regulation EPHB2 ANG 19254952 1165594 Positive_regulation EPHB2 ANG 19254952 1165595 Positive_regulation EPHB2 ANG 19254952 1165596 Positive_regulation EPHB2 ANG 19254952 1165597 Positive_regulation EPHB2 ANG 19254952 1165606 Positive_regulation EPHB2 ANG 19254952 1165615 Positive_regulation EPHB2 ANG 19254952 1165616 Positive_regulation EPHB2 ANG 19254952 1165617 Positive_regulation EPHB2 ANG 19254952 1165623 Positive_regulation EPHB2 ANG 19254952 1165624 Positive_regulation EPHB2 ANG 19254952 1165625 Positive_regulation EPHB2 ANG 19254952 1165626 Positive_regulation EPHB2 ANG 19254952 1165636 Positive_regulation EPHB2 ANG 19254952 1165639 Positive_regulation EPHB2 ANG 19254952 1165641 Positive_regulation EPHB2 ANGPT1 17341311 279567 Positive_regulation EPHB2 ANGPT1 19435476 659225 Positive_regulation EPHB2 ANGPT1 23653322 780690 Positive_regulation EPHB2 ANGPT2 17341311 279568 Positive_regulation EPHB2 ANGPT2 20808802 2472401 Positive_regulation EPHB2 ANGPT2 21167049 403506 Positive_regulation EPHB2 ANGPT2 22310788 1710685 Positive_regulation EPHB2 ANGPT2 23243430 816458 Positive_regulation EPHB2 ANGPT2 23243430 816466 Positive_regulation EPHB2 ANGPT2 23653322 780691 Positive_regulation EPHB2 ANGPT2 23690667 1752062 Positive_regulation EPHB2 ANGPT2 23691054 2794169 Positive_regulation EPHB2 ANGPT2 23691054 2794185 Positive_regulation EPHB2 ANGPT2 24827991 2969898 Positive_regulation EPHB2 ANGPT2 24827991 2969901 Positive_regulation EPHB2 ANGPT2 24827991 2969924 Positive_regulation EPHB2 ANGPT2 25393475 579064 Positive_regulation EPHB2 ANXA1 21635771 3084215 Positive_regulation EPHB2 ANXA6 23599172 2183040 Positive_regulation EPHB2 ANXA6 23599172 2183041 Positive_regulation EPHB2 APC 20403177 659542 Positive_regulation EPHB2 APC 25538703 921541 Positive_regulation EPHB2 APCS 22163180 1729419 Positive_regulation EPHB2 APCS 23230324 1713305 Positive_regulation EPHB2 APLN 21437254 2509140 Positive_regulation EPHB2 APLN 21437254 2509160 Positive_regulation EPHB2 APLN 21437254 2509184 Positive_regulation EPHB2 APLN 24227918 1916423 Positive_regulation EPHB2 APLN 24227918 1916424 Positive_regulation EPHB2 APLN 24227918 1916442 Positive_regulation EPHB2 APLN 24227918 1916446 Positive_regulation EPHB2 APOB 19158958 1908799 Positive_regulation EPHB2 APOB 19158958 1908868 Positive_regulation EPHB2 APOB 19247493 2406629 Positive_regulation EPHB2 APOB 23144813 2714615 Positive_regulation EPHB2 APOB 23144813 2714617 Positive_regulation EPHB2 APOB 23738035 2226031 Positive_regulation EPHB2 APOB 24386260 2903398 Positive_regulation EPHB2 APOB 24428917 1726706 Positive_regulation EPHB2 APOE 17166269 1890780 Positive_regulation EPHB2 AQP5 18478076 2388524 Positive_regulation EPHB2 AQP5 PMC4034029 2246244 Positive_regulation EPHB2 AR 21829568 2541869 Positive_regulation EPHB2 ARC 24045785 3137125 Positive_regulation EPHB2 AREG 21258428 1030561 Positive_regulation EPHB2 AREG 21258428 1030562 Positive_regulation EPHB2 AREG 21258428 1030604 Positive_regulation EPHB2 AREG 21258428 1030606 Positive_regulation EPHB2 AREG 24124521 2865982 Positive_regulation EPHB2 AREG 24124521 2865993 Positive_regulation EPHB2 ARF1 22790194 3164413 Positive_regulation EPHB2 ARF6 19247477 2406587 Positive_regulation EPHB2 ARF6 20462959 1776079 Positive_regulation EPHB2 ARF6 20462959 1776080 Positive_regulation EPHB2 ARF6 20462959 1776081 Positive_regulation EPHB2 ARF6 20462959 1776094 Positive_regulation EPHB2 ARF6 20462959 1776122 Positive_regulation EPHB2 ARF6 20462959 1776131 Positive_regulation EPHB2 ARF6 20462959 1776132 Positive_regulation EPHB2 ARG1 23466993 1709244 Positive_regulation EPHB2 ARG2 23466993 1709245 Positive_regulation EPHB2 ARHGAP8 23155002 1809599 Positive_regulation EPHB2 ARHGAP8 23155002 1809600 Positive_regulation EPHB2 ARHGAP8 23155002 1809622 Positive_regulation EPHB2 ARHGAP8 23155002 1809645 Positive_regulation EPHB2 ARHGEF2 22456508 1801503 Positive_regulation EPHB2 ARHGEF2 23389627 1811787 Positive_regulation EPHB2 ARHGEF7 22216034 22195 Positive_regulation EPHB2 ARHGEF7 22438844 951434 Positive_regulation EPHB2 ARTN 21450093 1898049 Positive_regulation EPHB2 ARTN 21450093 1898050 Positive_regulation EPHB2 ASIC1 22216270 2585200 Positive_regulation EPHB2 ASIC1 24923411 132729 Positive_regulation EPHB2 ASIC2 22216270 2585205 Positive_regulation EPHB2 ASIC3 22216270 2585201 Positive_regulation EPHB2 ASIC3 24923411 132730 Positive_regulation EPHB2 ASIC4 22216270 2585204 Positive_regulation EPHB2 ASIC5 22216270 2585203 Positive_regulation EPHB2 ATF2 20562914 2132678 Positive_regulation EPHB2 ATF4 23637839 2786222 Positive_regulation EPHB2 ATF6 21841811 13249 Positive_regulation EPHB2 ATG4B 24240988 1939491 Positive_regulation EPHB2 ATG7 24240988 1939490 Positive_regulation EPHB2 ATG7 24240988 1939497 Positive_regulation EPHB2 ATP5O 24006492 1818269 Positive_regulation EPHB2 AVP 15685238 425287 Positive_regulation EPHB2 AXL 25337673 2205658 Positive_regulation EPHB2 BANF1 22046349 2566800 Positive_regulation EPHB2 BANF1 23589723 818585 Positive_regulation EPHB2 BANF1 23589723 818586 Positive_regulation EPHB2 BANF1 23589723 818587 Positive_regulation EPHB2 BANF1 23589723 818593 Positive_regulation EPHB2 BANF1 23589723 818594 Positive_regulation EPHB2 BANF1 23589723 818600 Positive_regulation EPHB2 BANF1 23589723 818603 Positive_regulation EPHB2 BCL10 23586039 180947 Positive_regulation EPHB2 BCL10 23586039 181091 Positive_regulation EPHB2 BCL2 21912551 1144763 Positive_regulation EPHB2 BCL2 23363601 1811562 Positive_regulation EPHB2 BCR 11410123 350244 Positive_regulation EPHB2 BCR 11514608 1520634 Positive_regulation EPHB2 BCR 12093870 1523966 Positive_regulation EPHB2 BCR 14676298 1530027 Positive_regulation EPHB2 BCR 14676298 1530028 Positive_regulation EPHB2 BCR 14676298 1530222 Positive_regulation EPHB2 BCR 14735164 424148 Positive_regulation EPHB2 BCR 16009726 1321439 Positive_regulation EPHB2 BCR 16129705 1537099 Positive_regulation EPHB2 BCR 16301744 1538422 Positive_regulation EPHB2 BCR 16301744 1538448 Positive_regulation EPHB2 BCR 16301744 1538449 Positive_regulation EPHB2 BCR 16818674 1541069 Positive_regulation EPHB2 BCR 17349631 850538 Positive_regulation EPHB2 BCR 19847197 1719406 Positive_regulation EPHB2 BCR 19847197 1719432 Positive_regulation EPHB2 BCR 19897477 1167293 Positive_regulation EPHB2 BCR 19897477 1167300 Positive_regulation EPHB2 BCR 21441934 1955179 Positive_regulation EPHB2 BCR 21441934 1955246 Positive_regulation EPHB2 BCR 21441934 1955265 Positive_regulation EPHB2 BCR 22037603 1956042 Positive_regulation EPHB2 BCR 23072591 266618 Positive_regulation EPHB2 BCR 23505453 2766094 Positive_regulation EPHB2 BCR 24027568 908831 Positive_regulation EPHB2 BCR 24155950 2871731 Positive_regulation EPHB2 BCR 24765092 912332 Positive_regulation EPHB2 BCR 24901342 2976828 Positive_regulation EPHB2 BCR 24917786 932049 Positive_regulation EPHB2 BCR 9763608 1604024 Positive_regulation EPHB2 BCR 9763608 1604025 Positive_regulation EPHB2 BCR 9763608 1604026 Positive_regulation EPHB2 BCR 9763608 1604059 Positive_regulation EPHB2 BCR 9763608 1604060 Positive_regulation EPHB2 BCR 9763608 1604066 Positive_regulation EPHB2 BCR 9763608 1604071 Positive_regulation EPHB2 BCR 9763608 1604072 Positive_regulation EPHB2 BCR 9763608 1604076 Positive_regulation EPHB2 BCR 9763608 1604087 Positive_regulation EPHB2 BDKRB2 18036509 153707 Positive_regulation EPHB2 BDKRB2 18036509 153753 Positive_regulation EPHB2 BDKRB2 23826374 2812305 Positive_regulation EPHB2 BDNF 19039330 545803 Positive_regulation EPHB2 BDNF 19383130 525227 Positive_regulation EPHB2 BDNF 19383130 525247 Positive_regulation EPHB2 BDNF 19383130 525249 Positive_regulation EPHB2 BDNF 19390590 2414854 Positive_regulation EPHB2 BDNF 20062052 1965922 Positive_regulation EPHB2 BDNF 20154710 9461 Positive_regulation EPHB2 BDNF 20156366 255290 Positive_regulation EPHB2 BDNF 20156366 255291 Positive_regulation EPHB2 BDNF 20156366 255309 Positive_regulation EPHB2 BDNF 20156366 255310 Positive_regulation EPHB2 BDNF 20162012 1089315 Positive_regulation EPHB2 BDNF 20300619 2443882 Positive_regulation EPHB2 BDNF 20840753 1897671 Positive_regulation EPHB2 BDNF 20935641 1966413 Positive_regulation EPHB2 BDNF 21306618 1657758 Positive_regulation EPHB2 BDNF 21562076 719198 Positive_regulation EPHB2 BDNF 21849472 1793433 Positive_regulation EPHB2 BDNF 21849472 1793434 Positive_regulation EPHB2 BDNF 21849472 1793435 Positive_regulation EPHB2 BDNF 21849472 1793436 Positive_regulation EPHB2 BDNF 21849472 1793450 Positive_regulation EPHB2 BDNF 21958434 1659844 Positive_regulation EPHB2 BDNF 21958434 1659845 Positive_regulation EPHB2 BDNF 21958434 1659855 Positive_regulation EPHB2 BDNF 22022520 2563534 Positive_regulation EPHB2 BDNF 22022520 2563535 Positive_regulation EPHB2 BDNF 22022520 2563547 Positive_regulation EPHB2 BDNF 22022520 2563583 Positive_regulation EPHB2 BDNF 22022520 2563588 Positive_regulation EPHB2 BDNF 22022520 2563618 Positive_regulation EPHB2 BDNF 22654715 684375 Positive_regulation EPHB2 BDNF 22701758 2224468 Positive_regulation EPHB2 BDNF 23211962 1488899 Positive_regulation EPHB2 BDNF 23424281 2281565 Positive_regulation EPHB2 BDNF 23424281 2281620 Positive_regulation EPHB2 BDNF 23424281 2281621 Positive_regulation EPHB2 BDNF 23424281 2281657 Positive_regulation EPHB2 BDNF 23424281 2281824 Positive_regulation EPHB2 BDNF 23424281 2281927 Positive_regulation EPHB2 BDNF 23700454 2796236 Positive_regulation EPHB2 BDNF 23788034 563178 Positive_regulation EPHB2 BDNF 23874483 2821387 Positive_regulation EPHB2 BDNF 23914898 388655 Positive_regulation EPHB2 BDNF 23999075 2235859 Positive_regulation EPHB2 BDNF 24204683 2873206 Positive_regulation EPHB2 BDNF 24300402 2247576 Positive_regulation EPHB2 BDNF 24303055 2887884 Positive_regulation EPHB2 BDNF 24391468 2285187 Positive_regulation EPHB2 BDNF 24394804 1940171 Positive_regulation EPHB2 BDNF 24394804 1940172 Positive_regulation EPHB2 BDNF 24394804 1940281 Positive_regulation EPHB2 BDNF 24396335 684877 Positive_regulation EPHB2 BDNF 24642701 2935213 Positive_regulation EPHB2 BDNF 25051506 1886547 Positive_regulation EPHB2 BDNF 25249941 932983 Positive_regulation EPHB2 BDNF 25642163 939549 Positive_regulation EPHB2 BECN1 23853725 1153310 Positive_regulation EPHB2 BECN1 24053190 295053 Positive_regulation EPHB2 BLM 23472066 2763773 Positive_regulation EPHB2 BMP1 23969729 441591 Positive_regulation EPHB2 BMP1 24586814 2927115 Positive_regulation EPHB2 BMP1 24586814 2927117 Positive_regulation EPHB2 BMP10 23969729 441599 Positive_regulation EPHB2 BMP15 23969729 441592 Positive_regulation EPHB2 BMP2 19821774 1236716 Positive_regulation EPHB2 BMP2 22778550 1224457 Positive_regulation EPHB2 BMP2 23969729 441593 Positive_regulation EPHB2 BMP2 24373581 1482330 Positive_regulation EPHB2 BMP3 23969729 441594 Positive_regulation EPHB2 BMP4 18310445 1497446 Positive_regulation EPHB2 BMP4 20130821 1065812 Positive_regulation EPHB2 BMP4 20130821 1065847 Positive_regulation EPHB2 BMP4 23969729 441595 Positive_regulation EPHB2 BMP5 23186552 127364 Positive_regulation EPHB2 BMP5 23969729 441596 Positive_regulation EPHB2 BMP6 23969729 441597 Positive_regulation EPHB2 BMP7 22778550 1224458 Positive_regulation EPHB2 BMP7 23969729 441598 Positive_regulation EPHB2 BRAF 15149544 241398 Positive_regulation EPHB2 BRAF 16129781 1323440 Positive_regulation EPHB2 BRAF 18332218 1349869 Positive_regulation EPHB2 BRAF 18332218 1349870 Positive_regulation EPHB2 BRAF 18332218 1349871 Positive_regulation EPHB2 BRAF 18332218 1349872 Positive_regulation EPHB2 BRAF 18332218 1349873 Positive_regulation EPHB2 BRAF 18332218 1349921 Positive_regulation EPHB2 BRAF 18335053 2386951 Positive_regulation EPHB2 BRAF 18335053 2386975 Positive_regulation EPHB2 BRAF 18335053 2387024 Positive_regulation EPHB2 BRAF 18335053 2387094 Positive_regulation EPHB2 BRAF 19124656 1553513 Positive_regulation EPHB2 BRAF 19124656 1553514 Positive_regulation EPHB2 BRAF 19603027 432452 Positive_regulation EPHB2 BRAF 19804630 401930 Positive_regulation EPHB2 BRAF 19828018 1696426 Positive_regulation EPHB2 BRAF 19878585 254532 Positive_regulation EPHB2 BRAF 19878585 254539 Positive_regulation EPHB2 BRAF 20141835 516325 Positive_regulation EPHB2 BRAF 20141835 516360 Positive_regulation EPHB2 BRAF 21081934 436212 Positive_regulation EPHB2 BRAF 21107320 1986758 Positive_regulation EPHB2 BRAF 21203386 2489590 Positive_regulation EPHB2 BRAF 21203386 2489697 Positive_regulation EPHB2 BRAF 21437184 2234271 Positive_regulation EPHB2 BRAF 21479172 2510938 Positive_regulation EPHB2 BRAF 21505228 2175845 Positive_regulation EPHB2 BRAF 21505228 2175846 Positive_regulation EPHB2 BRAF 21752278 527598 Positive_regulation EPHB2 BRAF 22113612 1988013 Positive_regulation EPHB2 BRAF 22529971 2620780 Positive_regulation EPHB2 BRAF 22909976 478879 Positive_regulation EPHB2 BRAF 23085539 2181414 Positive_regulation EPHB2 BRAF 23208503 2150110 Positive_regulation EPHB2 BRAF 23317446 267323 Positive_regulation EPHB2 BRAF 23617957 1617865 Positive_regulation EPHB2 BRAF 23907581 3136569 Positive_regulation EPHB2 BRAF 23907581 3136583 Positive_regulation EPHB2 BRAF 24817905 656810 Positive_regulation EPHB2 BRAF 24918056 853891 Positive_regulation EPHB2 BRCA1 22087839 682002 Positive_regulation EPHB2 BRI3 25436889 3030684 Positive_regulation EPHB2 BSG 20107538 1037440 Positive_regulation EPHB2 BSG 20847954 1747912 Positive_regulation EPHB2 BSG 20847954 1747952 Positive_regulation EPHB2 BSG 21989251 398221 Positive_regulation EPHB2 BSG 24073208 2853398 Positive_regulation EPHB2 BSG 24073208 2853400 Positive_regulation EPHB2 BTC 24629040 1701525 Positive_regulation EPHB2 BTK 11410123 350239 Positive_regulation EPHB2 BTRC 11435472 1519604 Positive_regulation EPHB2 BTRC 15149544 241500 Positive_regulation EPHB2 BTRC 21559359 2518498 Positive_regulation EPHB2 BTRC 23420868 2085668 Positive_regulation EPHB2 C10orf10 21253578 2494474 Positive_regulation EPHB2 C1GALT1 24758762 2189385 Positive_regulation EPHB2 C1QA 16908670 1331932 Positive_regulation EPHB2 C1QA 16908670 1331953 Positive_regulation EPHB2 C1QA 19484134 2417890 Positive_regulation EPHB2 C1QB 16908670 1331933 Positive_regulation EPHB2 C1QB 16908670 1331954 Positive_regulation EPHB2 C1QB 19484134 2417891 Positive_regulation EPHB2 C3 23077507 2704690 Positive_regulation EPHB2 C3 23077507 2704706 Positive_regulation EPHB2 C3 23284683 2730533 Positive_regulation EPHB2 C5 22355325 2597210 Positive_regulation EPHB2 C5 22355325 2597214 Positive_regulation EPHB2 C5 24523571 1757459 Positive_regulation EPHB2 C5 24789665 1886428 Positive_regulation EPHB2 C5AR2 22355325 2597211 Positive_regulation EPHB2 C7orf41 24681962 219074 Positive_regulation EPHB2 C7orf41 24681962 219075 Positive_regulation EPHB2 C7orf41 24681962 219079 Positive_regulation EPHB2 C7orf41 24681962 219083 Positive_regulation EPHB2 C7orf41 24681962 219090 Positive_regulation EPHB2 CA2 11914123 276466 Positive_regulation EPHB2 CA2 11914123 276515 Positive_regulation EPHB2 CA2 14577832 3095278 Positive_regulation EPHB2 CA2 16278666 426770 Positive_regulation EPHB2 CA2 16278666 426775 Positive_regulation EPHB2 CA2 18404483 3087902 Positive_regulation EPHB2 CA2 18404483 3087903 Positive_regulation EPHB2 CA2 18404483 3087904 Positive_regulation EPHB2 CA2 18404491 3088319 Positive_regulation EPHB2 CA2 19432968 373110 Positive_regulation EPHB2 CA2 19712465 525795 Positive_regulation EPHB2 CA2 20071468 1773036 Positive_regulation EPHB2 CA2 20858281 1859195 Positive_regulation EPHB2 CA2 20872847 3171045 Positive_regulation EPHB2 CA2 21441934 1955181 Positive_regulation EPHB2 CA2 21441934 1955182 Positive_regulation EPHB2 CA2 21441934 1955183 Positive_regulation EPHB2 CA2 21441934 1955184 Positive_regulation EPHB2 CA2 21441934 1955185 Positive_regulation EPHB2 CA2 21441934 1955186 Positive_regulation EPHB2 CA2 21441934 1955187 Positive_regulation EPHB2 CA2 21441934 1955188 Positive_regulation EPHB2 CA2 21441934 1955189 Positive_regulation EPHB2 CA2 21441934 1955217 Positive_regulation EPHB2 CA2 21441934 1955218 Positive_regulation EPHB2 CA2 21441934 1955221 Positive_regulation EPHB2 CA2 21441934 1955222 Positive_regulation EPHB2 CA2 21441934 1955223 Positive_regulation EPHB2 CA2 21441934 1955224 Positive_regulation EPHB2 CA2 21441934 1955230 Positive_regulation EPHB2 CA2 21441934 1955231 Positive_regulation EPHB2 CA2 21441934 1955232 Positive_regulation EPHB2 CA2 21441934 1955233 Positive_regulation EPHB2 CA2 21441934 1955240 Positive_regulation EPHB2 CA2 21441934 1955241 Positive_regulation EPHB2 CA2 21441934 1955247 Positive_regulation EPHB2 CA2 21441934 1955254 Positive_regulation EPHB2 CA2 21441934 1955260 Positive_regulation EPHB2 CA2 21441934 1955263 Positive_regulation EPHB2 CA2 21441934 1955266 Positive_regulation EPHB2 CA2 21441934 1955276 Positive_regulation EPHB2 CA2 21441934 1955283 Positive_regulation EPHB2 CA2 21779236 933154 Positive_regulation EPHB2 CA2 22412973 2609904 Positive_regulation EPHB2 CA2 22412973 2609913 Positive_regulation EPHB2 CA2 22412973 2609914 Positive_regulation EPHB2 CA2 22412973 2609925 Positive_regulation EPHB2 CA2 22412973 2609926 Positive_regulation EPHB2 CA2 22904641 490805 Positive_regulation EPHB2 CA2 23905065 3188185 Positive_regulation EPHB2 CA2 23928293 3169644 Positive_regulation EPHB2 CA2 23991110 2840947 Positive_regulation EPHB2 CA2 24106480 962482 Positive_regulation EPHB2 CA2 24223965 2877507 Positive_regulation EPHB2 CA2 24381634 825015 Positive_regulation EPHB2 CA2 24499932 2299567 Positive_regulation EPHB2 CA2 24687958 1575552 Positive_regulation EPHB2 CA2 24872832 825920 Positive_regulation EPHB2 CA2 24897022 1127364 Positive_regulation EPHB2 CA2 24897022 1127368 Positive_regulation EPHB2 CA2 25121483 2997210 Positive_regulation EPHB2 CA2 25420019 3029477 Positive_regulation EPHB2 CA2 9763608 1604067 Positive_regulation EPHB2 CALM3 19498419 7534 Positive_regulation EPHB2 CALM3 20071468 1772992 Positive_regulation EPHB2 CALM3 21092323 1657399 Positive_regulation EPHB2 CALM3 22904641 490806 Positive_regulation EPHB2 CALM3 24381634 825016 Positive_regulation EPHB2 CALM3 25093823 2995358 Positive_regulation EPHB2 CALM3 9128257 1459898 Positive_regulation EPHB2 CALML3 22356547 660188 Positive_regulation EPHB2 CAMK1 20859543 3208956 Positive_regulation EPHB2 CAMK1 20859543 3209023 Positive_regulation EPHB2 CAMK4 20859543 3208957 Positive_regulation EPHB2 CAMKK1 20802521 2135490 Positive_regulation EPHB2 CAMKK1 20802521 2135504 Positive_regulation EPHB2 CAMKK1 20802521 2135505 Positive_regulation EPHB2 CAMKK1 20802521 2135520 Positive_regulation EPHB2 CAMKK1 20802521 2135568 Positive_regulation EPHB2 CAMKK1 20802521 2135569 Positive_regulation EPHB2 CAMKK1 20859543 3208918 Positive_regulation EPHB2 CAMKK1 20859543 3208958 Positive_regulation EPHB2 CAMKK1 20859543 3208993 Positive_regulation EPHB2 CAMKK2 20802521 2135491 Positive_regulation EPHB2 CAMKK2 20802521 2135506 Positive_regulation EPHB2 CAMKK2 20802521 2135507 Positive_regulation EPHB2 CAMKK2 20802521 2135508 Positive_regulation EPHB2 CAMKK2 20802521 2135510 Positive_regulation EPHB2 CAMKK2 20802521 2135521 Positive_regulation EPHB2 CAMKK2 20802521 2135570 Positive_regulation EPHB2 CAMKK2 20802521 2135571 Positive_regulation EPHB2 CAMKK2 20802521 2135602 Positive_regulation EPHB2 CAMKK2 20802521 2135619 Positive_regulation EPHB2 CAMKK2 20859543 3208919 Positive_regulation EPHB2 CAMKK2 20859543 3208959 Positive_regulation EPHB2 CAMKK2 20859543 3208994 Positive_regulation EPHB2 CAMP 21685939 2140297 Positive_regulation EPHB2 CAMP 21685939 2140298 Positive_regulation EPHB2 CAMP 21685939 2140335 Positive_regulation EPHB2 CAMP 21685939 2140336 Positive_regulation EPHB2 CAMP 21685939 2140383 Positive_regulation EPHB2 CAMP 21685939 2140397 Positive_regulation EPHB2 CAMP 21685939 2140437 Positive_regulation EPHB2 CAMP 21685939 2140442 Positive_regulation EPHB2 CAMP 21685939 2140443 Positive_regulation EPHB2 CAMP 21685939 2140444 Positive_regulation EPHB2 CAMP 21685939 2140459 Positive_regulation EPHB2 CAMP 21685939 2140465 Positive_regulation EPHB2 CAMP 21685939 2140466 Positive_regulation EPHB2 CAMP 21685939 2140467 Positive_regulation EPHB2 CAMP 21685939 2140468 Positive_regulation EPHB2 CAMP 22498979 3079517 Positive_regulation EPHB2 CAPN1 24394804 1940177 Positive_regulation EPHB2 CAPN1 24394804 1940178 Positive_regulation EPHB2 CAPN10 24394804 1940179 Positive_regulation EPHB2 CAPN10 24394804 1940180 Positive_regulation EPHB2 CAPN11 24394804 1940181 Positive_regulation EPHB2 CAPN11 24394804 1940182 Positive_regulation EPHB2 CAPN12 24394804 1940175 Positive_regulation EPHB2 CAPN12 24394804 1940176 Positive_regulation EPHB2 CAPN13 24394804 1940197 Positive_regulation EPHB2 CAPN13 24394804 1940198 Positive_regulation EPHB2 CAPN14 24394804 1940199 Positive_regulation EPHB2 CAPN14 24394804 1940200 Positive_regulation EPHB2 CAPN15 24394804 1940173 Positive_regulation EPHB2 CAPN15 24394804 1940174 Positive_regulation EPHB2 CAPN2 24394804 1940183 Positive_regulation EPHB2 CAPN2 24394804 1940184 Positive_regulation EPHB2 CAPN3 24394804 1940185 Positive_regulation EPHB2 CAPN3 24394804 1940186 Positive_regulation EPHB2 CAPN5 24394804 1940187 Positive_regulation EPHB2 CAPN5 24394804 1940188 Positive_regulation EPHB2 CAPN6 24394804 1940189 Positive_regulation EPHB2 CAPN6 24394804 1940190 Positive_regulation EPHB2 CAPN7 24394804 1940191 Positive_regulation EPHB2 CAPN7 24394804 1940192 Positive_regulation EPHB2 CAPN8 24394804 1940193 Positive_regulation EPHB2 CAPN8 24394804 1940194 Positive_regulation EPHB2 CAPN9 24394804 1940195 Positive_regulation EPHB2 CAPN9 24394804 1940196 Positive_regulation EPHB2 CARD11 22303480 2594904 Positive_regulation EPHB2 CARD11 22303480 2594933 Positive_regulation EPHB2 CASC3 25375375 578929 Positive_regulation EPHB2 CASP1 21037797 2301665 Positive_regulation EPHB2 CASP10 21037797 2301666 Positive_regulation EPHB2 CASP12 21037797 2301676 Positive_regulation EPHB2 CASP14 21037797 2301667 Positive_regulation EPHB2 CASP16 21037797 2301677 Positive_regulation EPHB2 CASP2 21037797 2301668 Positive_regulation EPHB2 CASP3 21037797 2301669 Positive_regulation EPHB2 CASP3 22952505 1149772 Positive_regulation EPHB2 CASP3 24755682 2957252 Positive_regulation EPHB2 CASP3 25206476 2004756 Positive_regulation EPHB2 CASP4 21037797 2301670 Positive_regulation EPHB2 CASP5 21037797 2301671 Positive_regulation EPHB2 CASP6 21037797 2301672 Positive_regulation EPHB2 CASP7 21037797 2301673 Positive_regulation EPHB2 CASP7 22276931 3084406 Positive_regulation EPHB2 CASP8 18036509 153685 Positive_regulation EPHB2 CASP8 18036509 153739 Positive_regulation EPHB2 CASP8 21037797 2301674 Positive_regulation EPHB2 CASP8 24611016 2122754 Positive_regulation EPHB2 CASP9 21037797 2301675 Positive_regulation EPHB2 CASR 23717692 2798798 Positive_regulation EPHB2 CAV1 17893196 1547061 Positive_regulation EPHB2 CAV1 19644556 1146851 Positive_regulation EPHB2 CAV1 23339737 534781 Positive_regulation EPHB2 CAV2 22229094 154616 Positive_regulation EPHB2 CAV2 22229094 154620 Positive_regulation EPHB2 CAV2 22229094 154634 Positive_regulation EPHB2 CBFA2T2 19737390 526046 Positive_regulation EPHB2 CBL 20123962 1557354 Positive_regulation EPHB2 CCL19 24915301 2979181 Positive_regulation EPHB2 CCL2 24586454 2924939 Positive_regulation EPHB2 CCL2 24597858 1650555 Positive_regulation EPHB2 CCL2 24826069 1917002 Positive_regulation EPHB2 CCL20 21949768 2556468 Positive_regulation EPHB2 CCL20 24436142 1023848 Positive_regulation EPHB2 CCL20 24979261 2985628 Positive_regulation EPHB2 CCL21 21698152 2530450 Positive_regulation EPHB2 CCL21 21698152 2530451 Positive_regulation EPHB2 CCL21 22438908 2611899 Positive_regulation EPHB2 CCL21 22438908 2611906 Positive_regulation EPHB2 CCL3 21403648 1720198 Positive_regulation EPHB2 CCL3 21403648 1720201 Positive_regulation EPHB2 CCL5 22506069 2618367 Positive_regulation EPHB2 CCL5 23326556 2740679 Positive_regulation EPHB2 CCL5 23326556 2740683 Positive_regulation EPHB2 CCNA2 20526329 1924916 Positive_regulation EPHB2 CCNA2 20930261 28338 Positive_regulation EPHB2 CCNA2 25187756 484814 Positive_regulation EPHB2 CCNA2 25187756 484817 Positive_regulation EPHB2 CCNC 22027397 1660023 Positive_regulation EPHB2 CCND1 10491389 1249399 Positive_regulation EPHB2 CCND1 20300579 3075068 Positive_regulation EPHB2 CCND1 21494592 2513251 Positive_regulation EPHB2 CCND1 22833568 1806095 Positive_regulation EPHB2 CCND1 24624361 947534 Positive_regulation EPHB2 CCND1 9864370 1473429 Positive_regulation EPHB2 CCND1 PMC2169457 1474880 Positive_regulation EPHB2 CCNT1 23658523 3061173 Positive_regulation EPHB2 CCR1 22807925 902523 Positive_regulation EPHB2 CCR6 24979261 2985629 Positive_regulation EPHB2 CCR6 24979261 2985641 Positive_regulation EPHB2 CCR7 21698152 2530452 Positive_regulation EPHB2 CCR7 21698152 2530453 Positive_regulation EPHB2 CCR7 21698152 2530464 Positive_regulation EPHB2 CCR7 22438908 2611900 Positive_regulation EPHB2 CCR7 22438908 2611901 Positive_regulation EPHB2 CCR7 22438908 2611907 Positive_regulation EPHB2 CD14 20827308 979274 Positive_regulation EPHB2 CD151 20581856 10207 Positive_regulation EPHB2 CD151 20581856 10210 Positive_regulation EPHB2 CD151 20581856 10211 Positive_regulation EPHB2 CD151 20581856 10216 Positive_regulation EPHB2 CD151 20581856 10219 Positive_regulation EPHB2 CD151 23292489 1886115 Positive_regulation EPHB2 CD2 18629305 793222 Positive_regulation EPHB2 CD2 18629305 793342 Positive_regulation EPHB2 CD2 18629305 793349 Positive_regulation EPHB2 CD2 18629305 793350 Positive_regulation EPHB2 CD2 18629305 793382 Positive_regulation EPHB2 CD2 18629305 793383 Positive_regulation EPHB2 CD209 18282094 3040986 Positive_regulation EPHB2 CD209 18282094 3040989 Positive_regulation EPHB2 CD24 22731636 1866175 Positive_regulation EPHB2 CD244 24687958 1575506 Positive_regulation EPHB2 CD244 24687958 1575534 Positive_regulation EPHB2 CD28 15833106 3104946 Positive_regulation EPHB2 CD28 15833106 3104974 Positive_regulation EPHB2 CD28 17548520 1546307 Positive_regulation EPHB2 CD28 22912825 2679451 Positive_regulation EPHB2 CD28 23431403 2755369 Positive_regulation EPHB2 CD28 24317039 1959478 Positive_regulation EPHB2 CD28 24317039 1959479 Positive_regulation EPHB2 CD28 24330710 538572 Positive_regulation EPHB2 CD28 24378539 1574352 Positive_regulation EPHB2 CD28 24465689 2911418 Positive_regulation EPHB2 CD36 19343212 3043671 Positive_regulation EPHB2 CD3D 9396757 1465234 Positive_regulation EPHB2 CD3D 9396757 1465237 Positive_regulation EPHB2 CD3E 9396757 1465235 Positive_regulation EPHB2 CD3E 9396757 1465238 Positive_regulation EPHB2 CD3G 9396757 1465236 Positive_regulation EPHB2 CD3G 9396757 1465239 Positive_regulation EPHB2 CD4 12566420 1525900 Positive_regulation EPHB2 CD4 12566420 1525901 Positive_regulation EPHB2 CD40 14981114 1531580 Positive_regulation EPHB2 CD40 18490492 1551307 Positive_regulation EPHB2 CD40 19399172 2415441 Positive_regulation EPHB2 CD40 19399172 2415459 Positive_regulation EPHB2 CD40 20100871 1557340 Positive_regulation EPHB2 CD40 21674065 2528586 Positive_regulation EPHB2 CD40 23524590 218332 Positive_regulation EPHB2 CD40 25215539 3007070 Positive_regulation EPHB2 CD40 9432981 1602403 Positive_regulation EPHB2 CD40 9432981 1602404 Positive_regulation EPHB2 CD40 9432981 1602405 Positive_regulation EPHB2 CD40 9432981 1602406 Positive_regulation EPHB2 CD40 9432981 1602407 Positive_regulation EPHB2 CD40 9432981 1602408 Positive_regulation EPHB2 CD40 9432981 1602409 Positive_regulation EPHB2 CD40 9432981 1602420 Positive_regulation EPHB2 CD40 9432981 1602421 Positive_regulation EPHB2 CD40 9432981 1602422 Positive_regulation EPHB2 CD40 9432981 1602442 Positive_regulation EPHB2 CD40 9432981 1602444 Positive_regulation EPHB2 CD40 9432981 1602449 Positive_regulation EPHB2 CD40 9432981 1602468 Positive_regulation EPHB2 CD40 9432981 1602475 Positive_regulation EPHB2 CD40LG 23072591 266607 Positive_regulation EPHB2 CD44 21283538 2495584 Positive_regulation EPHB2 CD44 21541039 1090756 Positive_regulation EPHB2 CD44 23304519 1497012 Positive_regulation EPHB2 CD44 23720662 907153 Positive_regulation EPHB2 CD46 24465142 842027 Positive_regulation EPHB2 CD5 20123962 1557355 Positive_regulation EPHB2 CD69 23776480 2804604 Positive_regulation EPHB2 CD69 24201811 568993 Positive_regulation EPHB2 CD74 21283538 2495569 Positive_regulation EPHB2 CD74 21283538 2495578 Positive_regulation EPHB2 CD74 21283538 2495585 Positive_regulation EPHB2 CD74 23522304 483064 Positive_regulation EPHB2 CD74 23720662 907154 Positive_regulation EPHB2 CD79A 12093870 1523967 Positive_regulation EPHB2 CD79A 14676298 1530029 Positive_regulation EPHB2 CD79A 14676298 1530030 Positive_regulation EPHB2 CD79A 14676298 1530223 Positive_regulation EPHB2 CD79A 14735164 424149 Positive_regulation EPHB2 CD79A 16009726 1321440 Positive_regulation EPHB2 CD79A 16301744 1538450 Positive_regulation EPHB2 CD79A 16818674 1541070 Positive_regulation EPHB2 CD79A 17349631 850539 Positive_regulation EPHB2 CD79A 19847197 1719407 Positive_regulation EPHB2 CD79A 19897477 1167294 Positive_regulation EPHB2 CD79A 19897477 1167301 Positive_regulation EPHB2 CD79A 21441934 1955191 Positive_regulation EPHB2 CD79A 21441934 1955248 Positive_regulation EPHB2 CD79A 21441934 1955267 Positive_regulation EPHB2 CD79A 22037603 1956043 Positive_regulation EPHB2 CD79A 24155950 2871732 Positive_regulation EPHB2 CD79A 24765092 912333 Positive_regulation EPHB2 CD79A 9763608 1604027 Positive_regulation EPHB2 CD79A 9763608 1604028 Positive_regulation EPHB2 CD79A 9763608 1604029 Positive_regulation EPHB2 CD79A 9763608 1604073 Positive_regulation EPHB2 CD79A 9763608 1604078 Positive_regulation EPHB2 CD79B 12093870 1523968 Positive_regulation EPHB2 CD79B 14676298 1530031 Positive_regulation EPHB2 CD79B 14676298 1530032 Positive_regulation EPHB2 CD79B 14676298 1530224 Positive_regulation EPHB2 CD79B 14735164 424150 Positive_regulation EPHB2 CD79B 16009726 1321441 Positive_regulation EPHB2 CD79B 16301744 1538451 Positive_regulation EPHB2 CD79B 16818674 1541071 Positive_regulation EPHB2 CD79B 17349631 850540 Positive_regulation EPHB2 CD79B 19847197 1719408 Positive_regulation EPHB2 CD79B 19897477 1167295 Positive_regulation EPHB2 CD79B 19897477 1167302 Positive_regulation EPHB2 CD79B 21441934 1955192 Positive_regulation EPHB2 CD79B 21441934 1955249 Positive_regulation EPHB2 CD79B 21441934 1955268 Positive_regulation EPHB2 CD79B 22037603 1956044 Positive_regulation EPHB2 CD79B 24155950 2871733 Positive_regulation EPHB2 CD79B 24765092 912334 Positive_regulation EPHB2 CD79B 9763608 1604030 Positive_regulation EPHB2 CD79B 9763608 1604031 Positive_regulation EPHB2 CD79B 9763608 1604032 Positive_regulation EPHB2 CD79B 9763608 1604074 Positive_regulation EPHB2 CD79B 9763608 1604079 Positive_regulation EPHB2 CD86 24317039 1959511 Positive_regulation EPHB2 CDC123 23272129 2729623 Positive_regulation EPHB2 CDC123 23272129 2729624 Positive_regulation EPHB2 CDC25A 23272087 2729556 Positive_regulation EPHB2 CDC42 21455314 2510243 Positive_regulation EPHB2 CDC42 23028410 2219980 Positive_regulation EPHB2 CDC42 23986484 1487160 Positive_regulation EPHB2 CDC42 24279335 1700981 Positive_regulation EPHB2 CDC42 24352036 1632455 Positive_regulation EPHB2 CDC73 21298035 2499387 Positive_regulation EPHB2 CDC73 21298035 2499388 Positive_regulation EPHB2 CDC73 23911909 1637726 Positive_regulation EPHB2 CDC73 23911909 1637727 Positive_regulation EPHB2 CDC73 23911909 1637792 Positive_regulation EPHB2 CDC73 23911909 1637802 Positive_regulation EPHB2 CDC73 23911909 1637803 Positive_regulation EPHB2 CDC73 23911909 1637830 Positive_regulation EPHB2 CDC73 23911909 1637831 Positive_regulation EPHB2 CDC73 23911909 1637832 Positive_regulation EPHB2 CDC73 24886678 1618984 Positive_regulation EPHB2 CDC73 25261977 1510727 Positive_regulation EPHB2 CDH1 11696562 1276046 Positive_regulation EPHB2 CDH1 22543706 14708 Positive_regulation EPHB2 CDH1 22543706 14709 Positive_regulation EPHB2 CDH1 22543706 14726 Positive_regulation EPHB2 CDH1 22543706 14738 Positive_regulation EPHB2 CDH1 22543706 14766 Positive_regulation EPHB2 CDH1 22543706 14767 Positive_regulation EPHB2 CDH13 22427889 2610557 Positive_regulation EPHB2 CDH2 20011526 2433526 Positive_regulation EPHB2 CDH2 21720547 2531615 Positive_regulation EPHB2 CDH5 18606845 1353416 Positive_regulation EPHB2 CDK19 22027397 1660028 Positive_regulation EPHB2 CDK8 22027397 1660026 Positive_regulation EPHB2 CDK9 23658523 3061174 Positive_regulation EPHB2 CDK9 23933651 18445 Positive_regulation EPHB2 CDK9 24643025 2935549 Positive_regulation EPHB2 CDK9 PMC4041476 746001 Positive_regulation EPHB2 CDKN1A 10491389 1249384 Positive_regulation EPHB2 CDKN1A 10491389 1249385 Positive_regulation EPHB2 CDKN1A 11134071 1266111 Positive_regulation EPHB2 CDKN1A 16351709 1844997 Positive_regulation EPHB2 CDKN1A 19068119 281916 Positive_regulation EPHB2 CDKN1A 20813052 1858396 Positive_regulation EPHB2 CDKN1A 20855497 1560286 Positive_regulation EPHB2 CDKN1A 23006971 2181055 Positive_regulation EPHB2 CDKN1A 9864370 1473430 Positive_regulation EPHB2 CEBPA 22039370 1038349 Positive_regulation EPHB2 CEBPA 23737812 637534 Positive_regulation EPHB2 CFLAR 16115325 1036185 Positive_regulation EPHB2 CHGA 22536432 2622458 Positive_regulation EPHB2 CHI3L1 18794340 1552067 Positive_regulation EPHB2 CHI3L1 22056877 2144452 Positive_regulation EPHB2 CHI3L1 23972995 609011 Positive_regulation EPHB2 CHI3L1 25358394 1946490 Positive_regulation EPHB2 CHI3L1 25358394 1946493 Positive_regulation EPHB2 CHKA 21772273 1933152 Positive_regulation EPHB2 CHKA 21772273 1933181 Positive_regulation EPHB2 CHUK 19252739 2406679 Positive_regulation EPHB2 CHUK 23752269 1905014 Positive_regulation EPHB2 CHUK 23752269 1905042 Positive_regulation EPHB2 CIB1 22964641 2148666 Positive_regulation EPHB2 CISH 20920317 257406 Positive_regulation EPHB2 CISH 20920317 257409 Positive_regulation EPHB2 CISH 20920317 257412 Positive_regulation EPHB2 CISH 20920317 257413 Positive_regulation EPHB2 CLEC7A 22883599 292382 Positive_regulation EPHB2 CLN3 24058789 1705647 Positive_regulation EPHB2 CLN3 24058789 1705716 Positive_regulation EPHB2 CLN5 24058789 1705648 Positive_regulation EPHB2 CLN5 24058789 1705717 Positive_regulation EPHB2 CLN6 24058789 1705649 Positive_regulation EPHB2 CLN6 24058789 1705718 Positive_regulation EPHB2 CLN8 24058789 1705650 Positive_regulation EPHB2 CLN8 24058789 1705719 Positive_regulation EPHB2 CLN9 24058789 1705651 Positive_regulation EPHB2 CLN9 24058789 1705720 Positive_regulation EPHB2 CLPS 25324930 2115674 Positive_regulation EPHB2 CMT2B 21151572 2485164 Positive_regulation EPHB2 CNR1 22235275 2585725 Positive_regulation EPHB2 CNR1 24391536 938522 Positive_regulation EPHB2 CNR1 24587189 2929002 Positive_regulation EPHB2 CNTN2 25175936 493092 Positive_regulation EPHB2 CNTN2 25175936 493093 Positive_regulation EPHB2 CNTN2 25175936 493097 Positive_regulation EPHB2 CNTN2 25175936 493098 Positive_regulation EPHB2 CNTN2 25175936 493099 Positive_regulation EPHB2 COL1A1 24011378 3114036 Positive_regulation EPHB2 COL1A1 24352036 1632411 Positive_regulation EPHB2 COL1A2 24011378 3114037 Positive_regulation EPHB2 COL1A2 24352036 1632412 Positive_regulation EPHB2 COL4A1 22349827 2146390 Positive_regulation EPHB2 COL4A2 22349827 2146391 Positive_regulation EPHB2 COL4A3 22349827 2146392 Positive_regulation EPHB2 COL4A4 22349827 2146393 Positive_regulation EPHB2 COL4A5 22349827 2146394 Positive_regulation EPHB2 COL4A6 22349827 2146395 Positive_regulation EPHB2 CPE 23977080 2838312 Positive_regulation EPHB2 CPE 23977080 2838320 Positive_regulation EPHB2 CPOX 20842125 435923 Positive_regulation EPHB2 CPOX 20842125 435924 Positive_regulation EPHB2 CPOX 20842125 435925 Positive_regulation EPHB2 CPP 21960960 933804 Positive_regulation EPHB2 CREB1 19917132 385866 Positive_regulation EPHB2 CREB1 19956756 2432690 Positive_regulation EPHB2 CREB1 22754300 1095930 Positive_regulation EPHB2 CREB1 23482441 2162228 Positive_regulation EPHB2 CREB1 25365078 2206647 Positive_regulation EPHB2 CREB3 19917132 385867 Positive_regulation EPHB2 CREB3 19956756 2432691 Positive_regulation EPHB2 CREB3 22754300 1095931 Positive_regulation EPHB2 CREB3 23482441 2162229 Positive_regulation EPHB2 CREB3 25365078 2206648 Positive_regulation EPHB2 CREB5 19917132 385865 Positive_regulation EPHB2 CREB5 19956756 2432689 Positive_regulation EPHB2 CREB5 22754300 1095929 Positive_regulation EPHB2 CREB5 23482441 2162227 Positive_regulation EPHB2 CREB5 25365078 2206646 Positive_regulation EPHB2 CREG1 24018888 1112426 Positive_regulation EPHB2 CREG1 24018888 1112427 Positive_regulation EPHB2 CREG1 24018888 1112455 Positive_regulation EPHB2 CRH 22529971 2620796 Positive_regulation EPHB2 CRK 10477763 1249186 Positive_regulation EPHB2 CRK 10477763 1249221 Positive_regulation EPHB2 CRK 19426560 525596 Positive_regulation EPHB2 CRK 21488184 3232766 Positive_regulation EPHB2 CRK 22245064 613504 Positive_regulation EPHB2 CRK 23389627 1811785 Positive_regulation EPHB2 CRK 23389627 1811954 Positive_regulation EPHB2 CRK 24058693 2848579 Positive_regulation EPHB2 CRK 24146543 1916415 Positive_regulation EPHB2 CRKL 24805778 1883740 Positive_regulation EPHB2 CROT 15575964 1844357 Positive_regulation EPHB2 CROT 21107320 1986741 Positive_regulation EPHB2 CROT 21107320 1986757 Positive_regulation EPHB2 CROT 21505228 2175889 Positive_regulation EPHB2 CROT 24966667 743145 Positive_regulation EPHB2 CRS 23346300 2115256 Positive_regulation EPHB2 CRY2 24667437 2938713 Positive_regulation EPHB2 CSE 21738617 2532952 Positive_regulation EPHB2 CSE 23236317 3204604 Positive_regulation EPHB2 CSE 23236317 3204608 Positive_regulation EPHB2 CSE 25165413 1761847 Positive_regulation EPHB2 CSF1 10648566 1255384 Positive_regulation EPHB2 CSF1 18852899 2397599 Positive_regulation EPHB2 CSF1 22028782 2564118 Positive_regulation EPHB2 CSF1 22028782 2564119 Positive_regulation EPHB2 CSF1 22028782 2564120 Positive_regulation EPHB2 CSF1 22028782 2564151 Positive_regulation EPHB2 CSF1 22028782 2564177 Positive_regulation EPHB2 CSF1 22028782 2564194 Positive_regulation EPHB2 CSF1 22028782 2564205 Positive_regulation EPHB2 CSF1 22028782 2564241 Positive_regulation EPHB2 CSF1 22028782 2564242 Positive_regulation EPHB2 CSF1 22028782 2564243 Positive_regulation EPHB2 CSF1 22028782 2564252 Positive_regulation EPHB2 CSF1 22028782 2564268 Positive_regulation EPHB2 CSF1 22028782 2564286 Positive_regulation EPHB2 CSF1 22873932 532961 Positive_regulation EPHB2 CSF1 23162740 589253 Positive_regulation EPHB2 CSF1 23752925 611266 Positive_regulation EPHB2 CSF1 24669294 847610 Positive_regulation EPHB2 CSF1 24743235 2954900 Positive_regulation EPHB2 CSF1 24752325 2956566 Positive_regulation EPHB2 CSF1 25134536 1883920 Positive_regulation EPHB2 CSF1 25313137 2205085 Positive_regulation EPHB2 CSF1 25313137 2205096 Positive_regulation EPHB2 CSF2 19426550 282401 Positive_regulation EPHB2 CSF2 19727076 1983915 Positive_regulation EPHB2 CSF2 23752925 611267 Positive_regulation EPHB2 CSF2 23752925 611268 Positive_regulation EPHB2 CSF2 24009832 203605 Positive_regulation EPHB2 CSF3 21422169 1562928 Positive_regulation EPHB2 CSF3 24220695 442483 Positive_regulation EPHB2 CSF3 24220695 442493 Positive_regulation EPHB2 CSK 21042538 2479708 Positive_regulation EPHB2 CSK 22783258 902303 Positive_regulation EPHB2 CSK 24205328 2876019 Positive_regulation EPHB2 CSK 24317039 1959508 Positive_regulation EPHB2 CST3 19956729 2432661 Positive_regulation EPHB2 CTGF 16774692 106024 Positive_regulation EPHB2 CTGF 18789696 3190785 Positive_regulation EPHB2 CTGF 19852794 1227704 Positive_regulation EPHB2 CTGF 19922639 117868 Positive_regulation EPHB2 CTGF 20507556 855041 Positive_regulation EPHB2 CTGF 20858895 1188517 Positive_regulation EPHB2 CTGF 20858895 1188521 Positive_regulation EPHB2 CTGF 20858895 1188523 Positive_regulation EPHB2 CTGF 20858895 1188543 Positive_regulation EPHB2 CTGF 22135505 3128242 Positive_regulation EPHB2 CTGF 23227240 2725728 Positive_regulation EPHB2 CTGF 23383241 2749634 Positive_regulation EPHB2 CTGF 24637722 2934843 Positive_regulation EPHB2 CTGF 24637722 2934848 Positive_regulation EPHB2 CTLA4 19783989 1953237 Positive_regulation EPHB2 CTNND1 10477763 1249187 Positive_regulation EPHB2 CTNND1 10477763 1249222 Positive_regulation EPHB2 CTNND1 10477763 1249325 Positive_regulation EPHB2 CTR9 21298035 2499389 Positive_regulation EPHB2 CTR9 21298035 2499390 Positive_regulation EPHB2 CTR9 23911909 1637728 Positive_regulation EPHB2 CTR9 23911909 1637729 Positive_regulation EPHB2 CTR9 23911909 1637793 Positive_regulation EPHB2 CTR9 23911909 1637804 Positive_regulation EPHB2 CTR9 23911909 1637805 Positive_regulation EPHB2 CTR9 23911909 1637833 Positive_regulation EPHB2 CTR9 23911909 1637834 Positive_regulation EPHB2 CTR9 23911909 1637835 Positive_regulation EPHB2 CTR9 24886678 1618985 Positive_regulation EPHB2 CTR9 25261977 1510728 Positive_regulation EPHB2 CTSC 24376709 2901864 Positive_regulation EPHB2 CTSC 24376709 2901865 Positive_regulation EPHB2 CTSC 24376709 2901876 Positive_regulation EPHB2 CTSC 24376709 2901885 Positive_regulation EPHB2 CTSC 24376709 2901886 Positive_regulation EPHB2 CTSC 24376709 2901898 Positive_regulation EPHB2 CTSC 24376709 2901899 Positive_regulation EPHB2 CTSC 24376709 2901906 Positive_regulation EPHB2 CTSG 24860547 880614 Positive_regulation EPHB2 CUL1 11435472 1519605 Positive_regulation EPHB2 CUL1 11435472 1519619 Positive_regulation EPHB2 CUL1 14981116 1531615 Positive_regulation EPHB2 CUL1 15149544 241501 Positive_regulation EPHB2 CUL1 21559359 2518499 Positive_regulation EPHB2 CUL1 23420868 2085669 Positive_regulation EPHB2 CUL1 24715976 848805 Positive_regulation EPHB2 CX3CL1 19840952 513415 Positive_regulation EPHB2 CX3CL1 19840952 513416 Positive_regulation EPHB2 CX3CL1 19840952 513417 Positive_regulation EPHB2 CX3CL1 19840952 513418 Positive_regulation EPHB2 CX3CL1 19840952 513460 Positive_regulation EPHB2 CX3CL1 19840952 513469 Positive_regulation EPHB2 CX3CR1 19840952 513470 Positive_regulation EPHB2 CXCL10 25415223 2207277 Positive_regulation EPHB2 CXCL11 22916293 2680702 Positive_regulation EPHB2 CXCL11 24586980 2928630 Positive_regulation EPHB2 CXCL12 19106094 1165209 Positive_regulation EPHB2 CXCL12 19106094 1165220 Positive_regulation EPHB2 CXCL12 19106094 1165221 Positive_regulation EPHB2 CXCL12 19687226 1555806 Positive_regulation EPHB2 CXCL12 19687226 1555818 Positive_regulation EPHB2 CXCL12 20010845 1953423 Positive_regulation EPHB2 CXCL12 20010845 1953425 Positive_regulation EPHB2 CXCL12 20376365 2445441 Positive_regulation EPHB2 CXCL12 20376365 2445442 Positive_regulation EPHB2 CXCL12 20376365 2445468 Positive_regulation EPHB2 CXCL12 21045835 436127 Positive_regulation EPHB2 CXCL12 21483439 1720217 Positive_regulation EPHB2 CXCL12 21483439 1720219 Positive_regulation EPHB2 CXCL12 21483439 1720224 Positive_regulation EPHB2 CXCL12 21655198 2527634 Positive_regulation EPHB2 CXCL12 21892172 1955789 Positive_regulation EPHB2 CXCL12 22152016 469596 Positive_regulation EPHB2 CXCL12 22319600 2595589 Positive_regulation EPHB2 CXCL12 22319600 2595590 Positive_regulation EPHB2 CXCL12 22319600 2595592 Positive_regulation EPHB2 CXCL12 22336518 1724476 Positive_regulation EPHB2 CXCL12 22336518 1724493 Positive_regulation EPHB2 CXCL12 22336518 1724513 Positive_regulation EPHB2 CXCL12 22412835 2609292 Positive_regulation EPHB2 CXCL12 22916293 2680703 Positive_regulation EPHB2 CXCL12 23098564 1231467 Positive_regulation EPHB2 CXCL12 23251606 2729162 Positive_regulation EPHB2 CXCL12 23251606 2729168 Positive_regulation EPHB2 CXCL12 23308188 2738589 Positive_regulation EPHB2 CXCL12 23308188 2738609 Positive_regulation EPHB2 CXCL12 23308188 2738638 Positive_regulation EPHB2 CXCL12 23308188 2738675 Positive_regulation EPHB2 CXCL12 23308188 2738679 Positive_regulation EPHB2 CXCL12 23383139 2748099 Positive_regulation EPHB2 CXCL12 23497290 1867529 Positive_regulation EPHB2 CXCL12 23497290 1867543 Positive_regulation EPHB2 CXCL12 23497290 1867544 Positive_regulation EPHB2 CXCL12 23497290 1867552 Positive_regulation EPHB2 CXCL12 23561540 535957 Positive_regulation EPHB2 CXCL12 24058588 2848113 Positive_regulation EPHB2 CXCL12 24058588 2848114 Positive_regulation EPHB2 CXCL12 24058588 2848121 Positive_regulation EPHB2 CXCL12 24058588 2848122 Positive_regulation EPHB2 CXCL12 24091662 567286 Positive_regulation EPHB2 CXCL12 24091662 567287 Positive_regulation EPHB2 CXCL12 24091662 567290 Positive_regulation EPHB2 CXCL12 24091662 567291 Positive_regulation EPHB2 CXCL12 24091662 567300 Positive_regulation EPHB2 CXCL12 24390633 646099 Positive_regulation EPHB2 CXCL12 24390633 646103 Positive_regulation EPHB2 CXCL12 24598933 2931693 Positive_regulation EPHB2 CXCL12 24598933 2931694 Positive_regulation EPHB2 CXCL12 24598933 2931708 Positive_regulation EPHB2 CXCL12 24598933 2931723 Positive_regulation EPHB2 CXCL12 24886617 474988 Positive_regulation EPHB2 CXCL12 24886617 475002 Positive_regulation EPHB2 CXCL12 24938229 1883864 Positive_regulation EPHB2 CXCL12 24991762 576768 Positive_regulation EPHB2 CXCL12 25121739 2997337 Positive_regulation EPHB2 CXCL12 25312253 3146129 Positive_regulation EPHB2 CXCL12 25312253 3146130 Positive_regulation EPHB2 CXCL13 23800251 1627133 Positive_regulation EPHB2 CXCR1 21249198 2493282 Positive_regulation EPHB2 CXCR2 21249198 2493283 Positive_regulation EPHB2 CXCR2 24580964 1667725 Positive_regulation EPHB2 CXCR4 19106094 1165192 Positive_regulation EPHB2 CXCR4 19106094 1165210 Positive_regulation EPHB2 CXCR4 20010845 1953419 Positive_regulation EPHB2 CXCR4 20010845 1953426 Positive_regulation EPHB2 CXCR4 21483439 1720218 Positive_regulation EPHB2 CXCR4 22472349 1698249 Positive_regulation EPHB2 CXCR4 22807925 902524 Positive_regulation EPHB2 CXCR4 23133664 2713678 Positive_regulation EPHB2 CXCR4 23251606 2729163 Positive_regulation EPHB2 CXCR4 23251606 2729169 Positive_regulation EPHB2 CXCR4 23308188 2738586 Positive_regulation EPHB2 CXCR4 23308188 2738590 Positive_regulation EPHB2 CXCR4 23308188 2738595 Positive_regulation EPHB2 CXCR4 23308188 2738611 Positive_regulation EPHB2 CXCR4 23308188 2738612 Positive_regulation EPHB2 CXCR4 23308188 2738648 Positive_regulation EPHB2 CXCR4 23308188 2738676 Positive_regulation EPHB2 CXCR4 23308188 2738687 Positive_regulation EPHB2 CXCR4 23308188 2738688 Positive_regulation EPHB2 CXCR4 23308188 2738690 Positive_regulation EPHB2 CXCR4 23322021 1100503 Positive_regulation EPHB2 CXCR4 23758320 151508 Positive_regulation EPHB2 CXCR4 23758320 151517 Positive_regulation EPHB2 CXCR4 23961808 483819 Positive_regulation EPHB2 CXCR4 24091662 567280 Positive_regulation EPHB2 CXCR4 24184055 1041137 Positive_regulation EPHB2 CYCS 22952505 1149773 Positive_regulation EPHB2 CYLD 25389768 3025155 Positive_regulation EPHB2 CYP2C19 18618001 2305575 Positive_regulation EPHB2 CYSLTR1 18404483 3088166 Positive_regulation EPHB2 CYSLTR1 24253666 3138731 Positive_regulation EPHB2 DAB1 23318582 610941 Positive_regulation EPHB2 DAB1 23318582 610942 Positive_regulation EPHB2 DAG1 20163697 526492 Positive_regulation EPHB2 DAG1 20625412 1215624 Positive_regulation EPHB2 DAP 21042538 2479714 Positive_regulation EPHB2 DAP 25291178 3012678 Positive_regulation EPHB2 DBT 25295277 200798 Positive_regulation EPHB2 DDAH2 25121106 196647 Positive_regulation EPHB2 DDX20 22348054 2596639 Positive_regulation EPHB2 DEFB1 22498979 3079518 Positive_regulation EPHB2 DEPDC1B 25091805 1234424 Positive_regulation EPHB2 DEPDC1B 25091805 1234503 Positive_regulation EPHB2 DERL1 24667437 2938737 Positive_regulation EPHB2 DFFB 21939503 1863430 Positive_regulation EPHB2 DISC1 25013758 194483 Positive_regulation EPHB2 DISC2 25013758 194484 Positive_regulation EPHB2 DLG4 22832728 3189160 Positive_regulation EPHB2 DLK1 23840193 878942 Positive_regulation EPHB2 DLK1 23840193 878959 Positive_regulation EPHB2 DLK1 25566082 967309 Positive_regulation EPHB2 DNLZ 12821648 1293162 Positive_regulation EPHB2 DNLZ 12821648 1293206 Positive_regulation EPHB2 DNLZ 12821648 1293207 Positive_regulation EPHB2 DNLZ 12821648 1293231 Positive_regulation EPHB2 DNLZ 12821648 1293269 Positive_regulation EPHB2 DNM1 16787538 3096304 Positive_regulation EPHB2 DNM1 25302800 3014684 Positive_regulation EPHB2 DNM2 16787538 3096305 Positive_regulation EPHB2 DNM2 25302800 3014685 Positive_regulation EPHB2 DNM3 16787538 3096303 Positive_regulation EPHB2 DNM3 25302800 3014683 Positive_regulation EPHB2 DNMT1 24358134 2898650 Positive_regulation EPHB2 DOCK1 10477763 1249252 Positive_regulation EPHB2 DOK1 22514638 2619607 Positive_regulation EPHB2 DOK3 22761938 2659383 Positive_regulation EPHB2 DOK3 22761938 2659398 Positive_regulation EPHB2 DOK3 22761938 2659429 Positive_regulation EPHB2 DOK3 22761938 2659434 Positive_regulation EPHB2 DPP4 23805228 2807951 Positive_regulation EPHB2 DPP4 24755682 2957262 Positive_regulation EPHB2 DPT 21494377 1037957 Positive_regulation EPHB2 DRD1 22590645 2642372 Positive_regulation EPHB2 DRD2 24658464 2188408 Positive_regulation EPHB2 DRD2 24658464 2188409 Positive_regulation EPHB2 DST 19479013 793540 Positive_regulation EPHB2 DST 19538739 1696327 Positive_regulation EPHB2 DST 20870566 794147 Positive_regulation EPHB2 DST 20950447 788978 Positive_regulation EPHB2 DTX1 23451269 2758475 Positive_regulation EPHB2 DTX1 23566222 1867819 Positive_regulation EPHB2 DTX2 23566222 1867816 Positive_regulation EPHB2 DTX3 23566222 1867817 Positive_regulation EPHB2 DTX4 23566222 1867818 Positive_regulation EPHB2 DUSP1 19476641 1897214 Positive_regulation EPHB2 DUSP1 20935641 1966414 Positive_regulation EPHB2 DUSP1 21610072 1191627 Positive_regulation EPHB2 DUSP1 22235371 1687026 Positive_regulation EPHB2 DUSP1 23006971 2181267 Positive_regulation EPHB2 DUSP1 23226236 2723838 Positive_regulation EPHB2 DUSP1 23823128 2808694 Positive_regulation EPHB2 DUSP1 23861901 2820699 Positive_regulation EPHB2 DUSP1 24244156 3064956 Positive_regulation EPHB2 DUSP1 24244156 3064960 Positive_regulation EPHB2 DUSP1 24409315 2906864 Positive_regulation EPHB2 DUSP10 23006971 2181268 Positive_regulation EPHB2 DUSP11 23006971 2181269 Positive_regulation EPHB2 DUSP12 23006971 2181270 Positive_regulation EPHB2 DUSP13 23006971 2181262 Positive_regulation EPHB2 DUSP14 23006971 2181258 Positive_regulation EPHB2 DUSP15 23006971 2181257 Positive_regulation EPHB2 DUSP16 23006971 2181259 Positive_regulation EPHB2 DUSP18 23006971 2181260 Positive_regulation EPHB2 DUSP19 23006971 2181261 Positive_regulation EPHB2 DUSP2 23006971 2181271 Positive_regulation EPHB2 DUSP2 23060802 959397 Positive_regulation EPHB2 DUSP2 24367002 1574285 Positive_regulation EPHB2 DUSP2 24367002 1574290 Positive_regulation EPHB2 DUSP21 23006971 2181263 Positive_regulation EPHB2 DUSP22 23006971 2181256 Positive_regulation EPHB2 DUSP23 23006971 2181264 Positive_regulation EPHB2 DUSP26 23006971 2181266 Positive_regulation EPHB2 DUSP27 23006971 2181265 Positive_regulation EPHB2 DUSP28 23006971 2181279 Positive_regulation EPHB2 DUSP3 23006971 2181272 Positive_regulation EPHB2 DUSP4 23006971 2181273 Positive_regulation EPHB2 DUSP4 25372139 3022794 Positive_regulation EPHB2 DUSP5 19861649 505916 Positive_regulation EPHB2 DUSP5 23006971 2181274 Positive_regulation EPHB2 DUSP5 24651368 2936461 Positive_regulation EPHB2 DUSP6 19897477 1167224 Positive_regulation EPHB2 DUSP6 19897477 1167312 Positive_regulation EPHB2 DUSP6 21610072 1191628 Positive_regulation EPHB2 DUSP6 22769588 521321 Positive_regulation EPHB2 DUSP6 23006971 2181275 Positive_regulation EPHB2 DUSP6 23823128 2808695 Positive_regulation EPHB2 DUSP6 23823128 2808697 Positive_regulation EPHB2 DUSP7 23006971 2181276 Positive_regulation EPHB2 DUSP8 23006971 2181277 Positive_regulation EPHB2 DUSP9 23006971 2181278 Positive_regulation EPHB2 DYNLL1 21461354 2001888 Positive_regulation EPHB2 DYNLL1 21461354 2001889 Positive_regulation EPHB2 DYNLRB1 23755307 2802623 Positive_regulation EPHB2 ECM1 20507556 855012 Positive_regulation EPHB2 ECM1 21385341 259264 Positive_regulation EPHB2 ECM1 22802915 2219532 Positive_regulation EPHB2 ECM1 23304519 1497013 Positive_regulation EPHB2 ECM1 25499743 476614 Positive_regulation EPHB2 ECM2 20507556 855013 Positive_regulation EPHB2 ECM2 22802915 2219533 Positive_regulation EPHB2 ECM2 23304519 1497014 Positive_regulation EPHB2 EDC3 20479872 2450074 Positive_regulation EPHB2 EDC4 20479872 2450073 Positive_regulation EPHB2 EDN1 10330402 1246170 Positive_regulation EPHB2 EDN1 11897012 389913 Positive_regulation EPHB2 EDN1 12734570 173174 Positive_regulation EPHB2 EDN1 20507556 855014 Positive_regulation EPHB2 EDN1 20550706 402680 Positive_regulation EPHB2 EDN1 22043200 667829 Positive_regulation EPHB2 EDN1 22802915 2219534 Positive_regulation EPHB2 EDN1 24132149 1113425 Positive_regulation EPHB2 EDN1 24312288 2888392 Positive_regulation EPHB2 EDN1 24823877 1126532 Positive_regulation EPHB2 EDN1 24823877 1126563 Positive_regulation EPHB2 EDN1 24901342 2976844 Positive_regulation EPHB2 EDN1 9679149 1468948 Positive_regulation EPHB2 EDN2 10330402 1246171 Positive_regulation EPHB2 EDN3 10330402 1246172 Positive_regulation EPHB2 EDNRA 22802915 2219535 Positive_regulation EPHB2 EDNRA 24312288 2888391 Positive_regulation EPHB2 EFNA1 19001122 1359706 Positive_regulation EPHB2 EFNA1 20824214 2474161 Positive_regulation EPHB2 EFNA2 20824214 2474162 Positive_regulation EPHB2 EFNA3 20824214 2474163 Positive_regulation EPHB2 EFNA4 20824214 2474164 Positive_regulation EPHB2 EFNA5 20824214 2474165 Positive_regulation EPHB2 EFNA5 20824214 2474166 Positive_regulation EPHB2 EFNA5 20824214 2474167 Positive_regulation EPHB2 EFNA5 22022520 2563593 Positive_regulation EPHB2 EFNB1 19001122 1359707 Positive_regulation EPHB2 EFNB1 19025592 1897126 Positive_regulation EPHB2 EFNB1 19047466 1362057 Positive_regulation EPHB2 EFNB1 19047466 1362058 Positive_regulation EPHB2 EFNB1 19047466 1362059 Positive_regulation EPHB2 EFNB1 19047466 1362060 Positive_regulation EPHB2 EFNB1 19047466 1362061 Positive_regulation EPHB2 EFNB1 19047466 1362062 Positive_regulation EPHB2 EFNB1 19047466 1362150 Positive_regulation EPHB2 EFNB1 19047466 1362220 Positive_regulation EPHB2 EFNB1 19047466 1362221 Positive_regulation EPHB2 EFNB1 19047466 1362222 Positive_regulation EPHB2 EFNB1 20824214 2474168 Positive_regulation EPHB2 EFNB1 21390298 2275255 Positive_regulation EPHB2 EFNB1 22144690 1394362 Positive_regulation EPHB2 EFNB1 22879882 2672836 Positive_regulation EPHB2 EFNB1 22879882 2672868 Positive_regulation EPHB2 EFNB1 23143520 1967847 Positive_regulation EPHB2 EFNB1 23318582 610943 Positive_regulation EPHB2 EFNB1 23318582 611031 Positive_regulation EPHB2 EFNB1 23874863 2823386 Positive_regulation EPHB2 EFNB1 25247423 2288172 Positive_regulation EPHB2 EFNB1 25473648 1713035 Positive_regulation EPHB2 EFNB2 18694808 2012199 Positive_regulation EPHB2 EFNB2 20824214 2473973 Positive_regulation EPHB2 EFNB2 20824214 2474169 Positive_regulation EPHB2 EFNB2 21059214 1897757 Positive_regulation EPHB2 EFNB2 21390298 2275256 Positive_regulation EPHB2 EFNB2 23143520 1967848 Positive_regulation EPHB2 EFNB2 23593160 2779960 Positive_regulation EPHB2 EFNB2 25473648 1713036 Positive_regulation EPHB2 EFNB3 20824214 2474170 Positive_regulation EPHB2 EFNB3 21390298 2275257 Positive_regulation EPHB2 EFNB3 23143520 1967849 Positive_regulation EPHB2 EFNB3 23303128 558842 Positive_regulation EPHB2 EFNB3 25473648 1713037 Positive_regulation EPHB2 EGF 10330402 1246128 Positive_regulation EPHB2 EGF 11136824 1518277 Positive_regulation EPHB2 EGF 11257116 1267884 Positive_regulation EPHB2 EGF 11897012 389901 Positive_regulation EPHB2 EGF 11897012 389922 Positive_regulation EPHB2 EGF 11897012 389927 Positive_regulation EPHB2 EGF 12184796 389983 Positive_regulation EPHB2 EGF 12204819 791206 Positive_regulation EPHB2 EGF 12592371 422190 Positive_regulation EPHB2 EGF 12592371 422192 Positive_regulation EPHB2 EGF 14981116 1531639 Positive_regulation EPHB2 EGF 15870831 426085 Positive_regulation EPHB2 EGF 15939762 1320810 Positive_regulation EPHB2 EGF 16103225 1323198 Positive_regulation EPHB2 EGF 16189524 426352 Positive_regulation EPHB2 EGF 16271139 248970 Positive_regulation EPHB2 EGF 16280034 459491 Positive_regulation EPHB2 EGF 16301336 1325564 Positive_regulation EPHB2 EGF 16301336 1325573 Positive_regulation EPHB2 EGF 16365168 1326394 Positive_regulation EPHB2 EGF 16365168 1326395 Positive_regulation EPHB2 EGF 16365168 1326396 Positive_regulation EPHB2 EGF 16365168 1326397 Positive_regulation EPHB2 EGF 16365168 1326398 Positive_regulation EPHB2 EGF 16365168 1326399 Positive_regulation EPHB2 EGF 16365168 1326439 Positive_regulation EPHB2 EGF 16365168 1326441 Positive_regulation EPHB2 EGF 16709244 524750 Positive_regulation EPHB2 EGF 16984645 279372 Positive_regulation EPHB2 EGF 17211494 1083625 Positive_regulation EPHB2 EGF 17284314 1645193 Positive_regulation EPHB2 EGF 17692468 157415 Positive_regulation EPHB2 EGF 18004277 1902372 Positive_regulation EPHB2 EGF 18004277 1902373 Positive_regulation EPHB2 EGF 18004277 1902374 Positive_regulation EPHB2 EGF 18004277 1902375 Positive_regulation EPHB2 EGF 18004277 1902393 Positive_regulation EPHB2 EGF 18004277 1902394 Positive_regulation EPHB2 EGF 18004277 1902395 Positive_regulation EPHB2 EGF 18004277 1902396 Positive_regulation EPHB2 EGF 18004277 1902397 Positive_regulation EPHB2 EGF 18004277 1902423 Positive_regulation EPHB2 EGF 18004277 1902449 Positive_regulation EPHB2 EGF 18004277 1902450 Positive_regulation EPHB2 EGF 18004277 1902481 Positive_regulation EPHB2 EGF 18004277 1902492 Positive_regulation EPHB2 EGF 18004277 1902498 Positive_regulation EPHB2 EGF 18004277 1902509 Positive_regulation EPHB2 EGF 18218921 849396 Positive_regulation EPHB2 EGF 18335055 2387127 Positive_regulation EPHB2 EGF 18463697 2289728 Positive_regulation EPHB2 EGF 18573911 1352970 Positive_regulation EPHB2 EGF 18662397 1242944 Positive_regulation EPHB2 EGF 18762583 1357058 Positive_regulation EPHB2 EGF 18949068 2207853 Positive_regulation EPHB2 EGF 18949068 2207982 Positive_regulation EPHB2 EGF 19036157 463303 Positive_regulation EPHB2 EGF 19144211 463442 Positive_regulation EPHB2 EGF 19254952 1165612 Positive_regulation EPHB2 EGF 19254952 1165633 Positive_regulation EPHB2 EGF 19292901 401664 Positive_regulation EPHB2 EGF 19305741 682814 Positive_regulation EPHB2 EGF 19357636 1902899 Positive_regulation EPHB2 EGF 19357636 1902936 Positive_regulation EPHB2 EGF 19357636 1902994 Positive_regulation EPHB2 EGF 19357636 1902999 Positive_regulation EPHB2 EGF 19383130 525236 Positive_regulation EPHB2 EGF 19383130 525238 Positive_regulation EPHB2 EGF 19432968 373130 Positive_regulation EPHB2 EGF 19440307 2416443 Positive_regulation EPHB2 EGF 19517027 671869 Positive_regulation EPHB2 EGF 19551145 2419937 Positive_regulation EPHB2 EGF 19737390 526047 Positive_regulation EPHB2 EGF 19737390 526085 Positive_regulation EPHB2 EGF 19737390 526090 Positive_regulation EPHB2 EGF 19804630 401926 Positive_regulation EPHB2 EGF 19804630 401935 Positive_regulation EPHB2 EGF 19804630 401949 Positive_regulation EPHB2 EGF 19804630 401966 Positive_regulation EPHB2 EGF 19878579 283573 Positive_regulation EPHB2 EGF 19878579 283574 Positive_regulation EPHB2 EGF 19925682 327060 Positive_regulation EPHB2 EGF 20071468 1772934 Positive_regulation EPHB2 EGF 20071468 1772935 Positive_regulation EPHB2 EGF 20071468 1772993 Positive_regulation EPHB2 EGF 20071468 1773006 Positive_regulation EPHB2 EGF 20122271 1853408 Positive_regulation EPHB2 EGF 20126616 2439382 Positive_regulation EPHB2 EGF 20551953 435632 Positive_regulation EPHB2 EGF 20565814 526561 Positive_regulation EPHB2 EGF 20624904 1377600 Positive_regulation EPHB2 EGF 20700538 2458210 Positive_regulation EPHB2 EGF 20858895 1188544 Positive_regulation EPHB2 EGF 20967285 2478643 Positive_regulation EPHB2 EGF 20977782 3168106 Positive_regulation EPHB2 EGF 21087211 148187 Positive_regulation EPHB2 EGF 21123182 1189561 Positive_regulation EPHB2 EGF 21123182 1189564 Positive_regulation EPHB2 EGF 21151603 1912432 Positive_regulation EPHB2 EGF 21364665 550099 Positive_regulation EPHB2 EGF 21610072 1191629 Positive_regulation EPHB2 EGF 21610072 1191630 Positive_regulation EPHB2 EGF 21610072 1191631 Positive_regulation EPHB2 EGF 21610072 1191748 Positive_regulation EPHB2 EGF 21610072 1191753 Positive_regulation EPHB2 EGF 21610072 1191754 Positive_regulation EPHB2 EGF 21610072 1191755 Positive_regulation EPHB2 EGF 21716849 1239522 Positive_regulation EPHB2 EGF 21749705 1862845 Positive_regulation EPHB2 EGF 21765406 1931632 Positive_regulation EPHB2 EGF 21765406 1931633 Positive_regulation EPHB2 EGF 21799663 2294618 Positive_regulation EPHB2 EGF 21829671 2542258 Positive_regulation EPHB2 EGF 21829671 2542274 Positive_regulation EPHB2 EGF 21829671 2542275 Positive_regulation EPHB2 EGF 21849472 1793451 Positive_regulation EPHB2 EGF 21931179 29661 Positive_regulation EPHB2 EGF 21961726 261298 Positive_regulation EPHB2 EGF 22040803 3091361 Positive_regulation EPHB2 EGF 22042618 1392945 Positive_regulation EPHB2 EGF 22046349 2566527 Positive_regulation EPHB2 EGF 22088142 482407 Positive_regulation EPHB2 EGF 22193779 2177139 Positive_regulation EPHB2 EGF 22216034 22183 Positive_regulation EPHB2 EGF 22245064 613490 Positive_regulation EPHB2 EGF 22245064 613491 Positive_regulation EPHB2 EGF 22245064 613492 Positive_regulation EPHB2 EGF 22245064 613493 Positive_regulation EPHB2 EGF 22245064 613495 Positive_regulation EPHB2 EGF 22245064 613496 Positive_regulation EPHB2 EGF 22245064 613497 Positive_regulation EPHB2 EGF 22245064 613500 Positive_regulation EPHB2 EGF 22245064 613501 Positive_regulation EPHB2 EGF 22245064 613537 Positive_regulation EPHB2 EGF 22245064 613625 Positive_regulation EPHB2 EGF 22245064 613626 Positive_regulation EPHB2 EGF 22245064 613627 Positive_regulation EPHB2 EGF 22247000 777685 Positive_regulation EPHB2 EGF 22251451 469688 Positive_regulation EPHB2 EGF 22276155 2590223 Positive_regulation EPHB2 EGF 22276155 2590226 Positive_regulation EPHB2 EGF 22315058 438322 Positive_regulation EPHB2 EGF 22404972 528337 Positive_regulation EPHB2 EGF 22470391 1992753 Positive_regulation EPHB2 EGF 22528856 161524 Positive_regulation EPHB2 EGF 22675459 2648691 Positive_regulation EPHB2 EGF 22701712 2652216 Positive_regulation EPHB2 EGF 22701712 2652234 Positive_regulation EPHB2 EGF 22701712 2652239 Positive_regulation EPHB2 EGF 22701712 2652241 Positive_regulation EPHB2 EGF 22701712 2652242 Positive_regulation EPHB2 EGF 22701712 2652247 Positive_regulation EPHB2 EGF 22718907 1804767 Positive_regulation EPHB2 EGF 22777356 2147997 Positive_regulation EPHB2 EGF 22822368 1729492 Positive_regulation EPHB2 EGF 22822368 1729494 Positive_regulation EPHB2 EGF 22873932 533000 Positive_regulation EPHB2 EGF 22873932 533039 Positive_regulation EPHB2 EGF 22880131 2674545 Positive_regulation EPHB2 EGF 22904641 490797 Positive_regulation EPHB2 EGF 22920937 406783 Positive_regulation EPHB2 EGF 22920937 406785 Positive_regulation EPHB2 EGF 22927910 2680904 Positive_regulation EPHB2 EGF 22927910 2680994 Positive_regulation EPHB2 EGF 22967907 1506577 Positive_regulation EPHB2 EGF 22984397 2688295 Positive_regulation EPHB2 EGF 23028479 2691017 Positive_regulation EPHB2 EGF 23028692 2692510 Positive_regulation EPHB2 EGF 23028692 2692513 Positive_regulation EPHB2 EGF 23028692 2692518 Positive_regulation EPHB2 EGF 23060802 959341 Positive_regulation EPHB2 EGF 23109808 2121083 Positive_regulation EPHB2 EGF 23109808 2121086 Positive_regulation EPHB2 EGF 23133355 2297548 Positive_regulation EPHB2 EGF 23133759 1079512 Positive_regulation EPHB2 EGF 23144978 2715144 Positive_regulation EPHB2 EGF 23162692 3131668 Positive_regulation EPHB2 EGF 23162692 3131673 Positive_regulation EPHB2 EGF 23162692 3131684 Positive_regulation EPHB2 EGF 23267331 960514 Positive_regulation EPHB2 EGF 23383347 2750476 Positive_regulation EPHB2 EGF 23554171 780362 Positive_regulation EPHB2 EGF 23554919 2774045 Positive_regulation EPHB2 EGF 23559009 561046 Positive_regulation EPHB2 EGF 23559009 561047 Positive_regulation EPHB2 EGF 23559009 561092 Positive_regulation EPHB2 EGF 23613900 2782737 Positive_regulation EPHB2 EGF 23626807 2784846 Positive_regulation EPHB2 EGF 23637902 2786616 Positive_regulation EPHB2 EGF 23637902 2786620 Positive_regulation EPHB2 EGF 23670595 1106862 Positive_regulation EPHB2 EGF 23704935 2796661 Positive_regulation EPHB2 EGF 23754287 1207142 Positive_regulation EPHB2 EGF 23754287 1207150 Positive_regulation EPHB2 EGF 23800251 1627025 Positive_regulation EPHB2 EGF 23800251 1627060 Positive_regulation EPHB2 EGF 23800251 1627061 Positive_regulation EPHB2 EGF 23800251 1627062 Positive_regulation EPHB2 EGF 23800251 1627104 Positive_regulation EPHB2 EGF 23821666 2090937 Positive_regulation EPHB2 EGF 23825523 2809514 Positive_regulation EPHB2 EGF 23825523 2809517 Positive_regulation EPHB2 EGF 23833655 2165250 Positive_regulation EPHB2 EGF 23903585 3136539 Positive_regulation EPHB2 EGF 23903585 3136547 Positive_regulation EPHB2 EGF 23907581 3136571 Positive_regulation EPHB2 EGF 23907581 3136572 Positive_regulation EPHB2 EGF 23907581 3136573 Positive_regulation EPHB2 EGF 23907581 3136578 Positive_regulation EPHB2 EGF 23907581 3136586 Positive_regulation EPHB2 EGF 23908646 878995 Positive_regulation EPHB2 EGF 23908646 878996 Positive_regulation EPHB2 EGF 23911909 1637845 Positive_regulation EPHB2 EGF 23955284 161247 Positive_regulation EPHB2 EGF 23977387 2840257 Positive_regulation EPHB2 EGF 23990774 2298808 Positive_regulation EPHB2 EGF 24004716 473764 Positive_regulation EPHB2 EGF 24069528 750729 Positive_regulation EPHB2 EGF 24091658 566675 Positive_regulation EPHB2 EGF 24096486 2153883 Positive_regulation EPHB2 EGF 24124521 2865991 Positive_regulation EPHB2 EGF 24124521 2865992 Positive_regulation EPHB2 EGF 24155779 1240233 Positive_regulation EPHB2 EGF 24155779 1240250 Positive_regulation EPHB2 EGF 24155779 1240264 Positive_regulation EPHB2 EGF 24212795 498491 Positive_regulation EPHB2 EGF 24213113 499456 Positive_regulation EPHB2 EGF 24228035 3174180 Positive_regulation EPHB2 EGF 24240988 1939531 Positive_regulation EPHB2 EGF 24255704 2881793 Positive_regulation EPHB2 EGF 24321545 410793 Positive_regulation EPHB2 EGF 24434874 3158914 Positive_regulation EPHB2 EGF 24456610 484125 Positive_regulation EPHB2 EGF 24521094 539408 Positive_regulation EPHB2 EGF 24552586 389102 Positive_regulation EPHB2 EGF 24568222 1872208 Positive_regulation EPHB2 EGF 24568222 1872209 Positive_regulation EPHB2 EGF 24568222 1872213 Positive_regulation EPHB2 EGF 24577089 572559 Positive_regulation EPHB2 EGF 24586666 2926104 Positive_regulation EPHB2 EGF 24658031 2187633 Positive_regulation EPHB2 EGF 24667437 2938734 Positive_regulation EPHB2 EGF 24721622 1679074 Positive_regulation EPHB2 EGF 24721622 1679075 Positive_regulation EPHB2 EGF 24721622 1679294 Positive_regulation EPHB2 EGF 24744103 494843 Positive_regulation EPHB2 EGF 24744103 494898 Positive_regulation EPHB2 EGF 24775912 1874086 Positive_regulation EPHB2 EGF 24775912 1874102 Positive_regulation EPHB2 EGF 24820097 2968872 Positive_regulation EPHB2 EGF 24834259 979054 Positive_regulation EPHB2 EGF 24849047 1942127 Positive_regulation EPHB2 EGF 24849319 2972480 Positive_regulation EPHB2 EGF 24849319 2972485 Positive_regulation EPHB2 EGF 24885093 273141 Positive_regulation EPHB2 EGF 24886678 1618989 Positive_regulation EPHB2 EGF 24916153 399782 Positive_regulation EPHB2 EGF 24916153 399793 Positive_regulation EPHB2 EGF 24916153 399918 Positive_regulation EPHB2 EGF 24916153 399924 Positive_regulation EPHB2 EGF 24938229 1883866 Positive_regulation EPHB2 EGF 24957684 2232003 Positive_regulation EPHB2 EGF 24994965 650696 Positive_regulation EPHB2 EGF 25003232 2195000 Positive_regulation EPHB2 EGF 25009466 869647 Positive_regulation EPHB2 EGF 25009500 965397 Positive_regulation EPHB2 EGF 25051199 2991389 Positive_regulation EPHB2 EGF 25081058 612739 Positive_regulation EPHB2 EGF 25246767 743229 Positive_regulation EPHB2 EGF 25246767 743252 Positive_regulation EPHB2 EGF 25249457 704765 Positive_regulation EPHB2 EGF 25258648 1240851 Positive_regulation EPHB2 EGF 25258648 1240855 Positive_regulation EPHB2 EGF 25258648 1240864 Positive_regulation EPHB2 EGF 25258648 1240891 Positive_regulation EPHB2 EGF 25258648 1240901 Positive_regulation EPHB2 EGF 25258648 1240969 Positive_regulation EPHB2 EGF 25258648 1240981 Positive_regulation EPHB2 EGF 25278152 1946165 Positive_regulation EPHB2 EGF 25313137 2205086 Positive_regulation EPHB2 EGF 25333265 2205622 Positive_regulation EPHB2 EGF 25335797 3071190 Positive_regulation EPHB2 EGF 25364759 862479 Positive_regulation EPHB2 EGF 25421240 1135065 Positive_regulation EPHB2 EGF 25421240 1135066 Positive_regulation EPHB2 EGF 25421240 1135137 Positive_regulation EPHB2 EGF 25421240 1135192 Positive_regulation EPHB2 EGF 25499743 476615 Positive_regulation EPHB2 EGF 25514808 3034807 Positive_regulation EPHB2 EGF 25514808 3034812 Positive_regulation EPHB2 EGF 25514808 3035001 Positive_regulation EPHB2 EGF 25514808 3035006 Positive_regulation EPHB2 EGF 25514808 3035008 Positive_regulation EPHB2 EGFL7 24647208 2936068 Positive_regulation EPHB2 EGFL7 24647208 2936081 Positive_regulation EPHB2 EGFL7 24647208 2936089 Positive_regulation EPHB2 EGFR 11897012 389902 Positive_regulation EPHB2 EGFR 11897012 389914 Positive_regulation EPHB2 EGFR 14676298 1530033 Positive_regulation EPHB2 EGFR 15219238 523849 Positive_regulation EPHB2 EGFR 15305194 424883 Positive_regulation EPHB2 EGFR 15939762 1320797 Positive_regulation EPHB2 EGFR 17449939 1634804 Positive_regulation EPHB2 EGFR 17449939 1634805 Positive_regulation EPHB2 EGFR 17449939 1634822 Positive_regulation EPHB2 EGFR 17927446 2369134 Positive_regulation EPHB2 EGFR 18460189 2232692 Positive_regulation EPHB2 EGFR 19254952 1165591 Positive_regulation EPHB2 EGFR 19254952 1165592 Positive_regulation EPHB2 EGFR 19254952 1165593 Positive_regulation EPHB2 EGFR 19254952 1165604 Positive_regulation EPHB2 EGFR 19254952 1165605 Positive_regulation EPHB2 EGFR 19254952 1165613 Positive_regulation EPHB2 EGFR 19254952 1165614 Positive_regulation EPHB2 EGFR 19365582 1671107 Positive_regulation EPHB2 EGFR 19388902 590554 Positive_regulation EPHB2 EGFR 19563669 464529 Positive_regulation EPHB2 EGFR 19626123 2421835 Positive_regulation EPHB2 EGFR 19804630 401967 Positive_regulation EPHB2 EGFR 19840952 513419 Positive_regulation EPHB2 EGFR 19840952 513478 Positive_regulation EPHB2 EGFR 19935697 2128307 Positive_regulation EPHB2 EGFR 20122271 1853409 Positive_regulation EPHB2 EGFR 20422006 2447275 Positive_regulation EPHB2 EGFR 20828404 1858786 Positive_regulation EPHB2 EGFR 21092323 1657400 Positive_regulation EPHB2 EGFR 21179491 2488373 Positive_regulation EPHB2 EGFR 21203579 2273151 Positive_regulation EPHB2 EGFR 21258428 1030560 Positive_regulation EPHB2 EGFR 21258428 1030579 Positive_regulation EPHB2 EGFR 21258428 1030580 Positive_regulation EPHB2 EGFR 21258428 1030605 Positive_regulation EPHB2 EGFR 21347362 2503680 Positive_regulation EPHB2 EGFR 21445343 2509563 Positive_regulation EPHB2 EGFR 21461392 1052472 Positive_regulation EPHB2 EGFR 21595894 467797 Positive_regulation EPHB2 EGFR 21624123 1862246 Positive_regulation EPHB2 EGFR 21743488 2140767 Positive_regulation EPHB2 EGFR 21847121 437649 Positive_regulation EPHB2 EGFR 21961726 261111 Positive_regulation EPHB2 EGFR 21961726 261313 Positive_regulation EPHB2 EGFR 22043994 91919 Positive_regulation EPHB2 EGFR 22053213 2568068 Positive_regulation EPHB2 EGFR 22110740 2573120 Positive_regulation EPHB2 EGFR 22110740 2573138 Positive_regulation EPHB2 EGFR 22185378 1864572 Positive_regulation EPHB2 EGFR 22248929 2177366 Positive_regulation EPHB2 EGFR 22294553 777829 Positive_regulation EPHB2 EGFR 22294553 777830 Positive_regulation EPHB2 EGFR 22457794 2613742 Positive_regulation EPHB2 EGFR 22457794 2613743 Positive_regulation EPHB2 EGFR 22457794 2613763 Positive_regulation EPHB2 EGFR 22457794 2613767 Positive_regulation EPHB2 EGFR 22645717 939672 Positive_regulation EPHB2 EGFR 22701710 2652076 Positive_regulation EPHB2 EGFR 22747893 1664269 Positive_regulation EPHB2 EGFR 22758623 667981 Positive_regulation EPHB2 EGFR 22843679 1204089 Positive_regulation EPHB2 EGFR 22889873 2180647 Positive_regulation EPHB2 EGFR 22904641 490785 Positive_regulation EPHB2 EGFR 22904641 490817 Positive_regulation EPHB2 EGFR 22967907 1506555 Positive_regulation EPHB2 EGFR 22967907 1506571 Positive_regulation EPHB2 EGFR 22967907 1506578 Positive_regulation EPHB2 EGFR 22984397 2688269 Positive_regulation EPHB2 EGFR 22984397 2688285 Positive_regulation EPHB2 EGFR 22984397 2688296 Positive_regulation EPHB2 EGFR 22984397 2688306 Positive_regulation EPHB2 EGFR 22984397 2688314 Positive_regulation EPHB2 EGFR 22984397 2688317 Positive_regulation EPHB2 EGFR 22988345 1750576 Positive_regulation EPHB2 EGFR 22988500 1689646 Positive_regulation EPHB2 EGFR 23009336 1866983 Positive_regulation EPHB2 EGFR 23071748 2703896 Positive_regulation EPHB2 EGFR 23076445 2171056 Positive_regulation EPHB2 EGFR 23082072 2121077 Positive_regulation EPHB2 EGFR 23152903 2716784 Positive_regulation EPHB2 EGFR 23272129 2729627 Positive_regulation EPHB2 EGFR 23344022 1100587 Positive_regulation EPHB2 EGFR 23423570 726417 Positive_regulation EPHB2 EGFR 23449028 1102798 Positive_regulation EPHB2 EGFR 23552555 2155920 Positive_regulation EPHB2 EGFR 23554919 2774074 Positive_regulation EPHB2 EGFR 23617883 1867937 Positive_regulation EPHB2 EGFR 23617883 1867973 Positive_regulation EPHB2 EGFR 23663560 1868356 Positive_regulation EPHB2 EGFR 23762360 2803108 Positive_regulation EPHB2 EGFR 23762493 2804185 Positive_regulation EPHB2 EGFR 23800251 1627063 Positive_regulation EPHB2 EGFR 23821666 2090940 Positive_regulation EPHB2 EGFR 23829771 410477 Positive_regulation EPHB2 EGFR 23911909 1637812 Positive_regulation EPHB2 EGFR 23942551 728412 Positive_regulation EPHB2 EGFR 23991110 2840948 Positive_regulation EPHB2 EGFR 23991110 2840952 Positive_regulation EPHB2 EGFR 23991110 2840956 Positive_regulation EPHB2 EGFR 24015256 2842469 Positive_regulation EPHB2 EGFR 24168056 1700789 Positive_regulation EPHB2 EGFR 24220297 1920136 Positive_regulation EPHB2 EGFR 24260485 2884579 Positive_regulation EPHB2 EGFR 24267514 538438 Positive_regulation EPHB2 EGFR 24268047 1481983 Positive_regulation EPHB2 EGFR 24304271 682470 Positive_regulation EPHB2 EGFR 24340049 2894769 Positive_regulation EPHB2 EGFR 24349829 478324 Positive_regulation EPHB2 EGFR 24379833 2120025 Positive_regulation EPHB2 EGFR 24599172 2931855 Positive_regulation EPHB2 EGFR 24721622 1679076 Positive_regulation EPHB2 EGFR 24721622 1679156 Positive_regulation EPHB2 EGFR 24721622 1679179 Positive_regulation EPHB2 EGFR 24721622 1679239 Positive_regulation EPHB2 EGFR 24763051 574235 Positive_regulation EPHB2 EGFR 24816560 1487890 Positive_regulation EPHB2 EGFR 24843386 2168379 Positive_regulation EPHB2 EGFR 25068892 622527 Positive_regulation EPHB2 EGFR 25421240 1135027 Positive_regulation EPHB2 EGFR 25421240 1135067 Positive_regulation EPHB2 EGFR 25421240 1135138 Positive_regulation EPHB2 EGFR 25421240 1135139 Positive_regulation EPHB2 EGFR 25421240 1135259 Positive_regulation EPHB2 EGFR 25421240 1135260 Positive_regulation EPHB2 EGFR 25421240 1135267 Positive_regulation EPHB2 EGFR 25499743 476627 Positive_regulation EPHB2 EGR1 18315872 322373 Positive_regulation EPHB2 EGR1 18615184 3074355 Positive_regulation EPHB2 EGR1 19432968 373111 Positive_regulation EPHB2 EGR1 19956541 2432008 Positive_regulation EPHB2 EGR1 21298006 2499320 Positive_regulation EPHB2 EGR1 23284657 2730394 Positive_regulation EPHB2 EGR1 23468876 2759902 Positive_regulation EPHB2 EGR1 24312080 879564 Positive_regulation EPHB2 EGR2 22049075 1193850 Positive_regulation EPHB2 EHMT1 22412973 2609905 Positive_regulation EPHB2 EIF2AK1 23549262 1104715 Positive_regulation EPHB2 ELK1 14981092 1306411 Positive_regulation EPHB2 ELK1 19432968 373112 Positive_regulation EPHB2 ELK1 21258408 2137616 Positive_regulation EPHB2 EML4 22928112 155590 Positive_regulation EPHB2 ENPEP 24499932 2299552 Positive_regulation EPHB2 ENPEP 24499932 2299555 Positive_regulation EPHB2 ENPEP 24499932 2299560 Positive_regulation EPHB2 ENPEP 24499932 2299561 Positive_regulation EPHB2 EPCAM 22547929 1224076 Positive_regulation EPHB2 EPHA1 21559471 2519632 Positive_regulation EPHB2 EPHA1 22144690 1394324 Positive_regulation EPHB2 EPHA10 21559471 2519631 Positive_regulation EPHB2 EPHA10 22144690 1394323 Positive_regulation EPHB2 EPHA2 20130824 1671860 Positive_regulation EPHB2 EPHA2 21559471 2519633 Positive_regulation EPHB2 EPHA2 22144690 1394325 Positive_regulation EPHB2 EPHA2 22570727 2631474 Positive_regulation EPHB2 EPHA3 21559471 2519634 Positive_regulation EPHB2 EPHA3 22144690 1394310 Positive_regulation EPHB2 EPHA3 22144690 1394312 Positive_regulation EPHB2 EPHA3 22144690 1394326 Positive_regulation EPHB2 EPHA4 19001122 1359708 Positive_regulation EPHB2 EPHA4 21559471 2519635 Positive_regulation EPHB2 EPHA4 22144690 1394327 Positive_regulation EPHB2 EPHA5 20824214 2474171 Positive_regulation EPHB2 EPHA5 21559471 2519636 Positive_regulation EPHB2 EPHA5 22144690 1394328 Positive_regulation EPHB2 EPHA6 21559471 2519630 Positive_regulation EPHB2 EPHA6 22144690 1394322 Positive_regulation EPHB2 EPHA7 21559471 2519637 Positive_regulation EPHB2 EPHA7 22144690 1394329 Positive_regulation EPHB2 EPHA8 21559471 2519638 Positive_regulation EPHB2 EPHA8 22144690 1394330 Positive_regulation EPHB2 EPHB1 12925710 1296029 Positive_regulation EPHB2 EPHB1 12925710 1296030 Positive_regulation EPHB2 EPHB1 12925710 1296031 Positive_regulation EPHB2 EPHB1 12925710 1296051 Positive_regulation EPHB2 EPHB1 12925710 1296078 Positive_regulation EPHB2 EPHB1 12925710 1296085 Positive_regulation EPHB2 EPHB1 12925710 1296092 Positive_regulation EPHB2 EPHB1 12925710 1296102 Positive_regulation EPHB2 EPHB1 20824214 2474172 Positive_regulation EPHB2 EPHB4 25148033 3001314 Positive_regulation EPHB2 EPO 15149544 241399 Positive_regulation EPHB2 EPO 21860424 2142211 Positive_regulation EPHB2 EPO 21860424 2142215 Positive_regulation EPHB2 EPO 21860424 2142216 Positive_regulation EPHB2 EPO 21887333 2549329 Positive_regulation EPHB2 EPO 22384088 2603398 Positive_regulation EPHB2 EPO 22462028 507167 Positive_regulation EPHB2 EPO 22955851 439351 Positive_regulation EPHB2 EPO 23028796 2693071 Positive_regulation EPHB2 EPO 24416646 1708084 Positive_regulation EPHB2 EPOR 21860424 2142219 Positive_regulation EPHB2 EPOR 23028796 2693072 Positive_regulation EPHB2 EPX 15149544 241480 Positive_regulation EPHB2 EPX 19755525 711108 Positive_regulation EPHB2 EPX 20029368 1903284 Positive_regulation EPHB2 EPX 21415991 1764456 Positive_regulation EPHB2 EPX 21860424 2142210 Positive_regulation EPHB2 EPX 21860424 2142212 Positive_regulation EPHB2 EPX 22044999 1933379 Positive_regulation EPHB2 EPX 22044999 1933382 Positive_regulation EPHB2 EPX 24086539 2854583 Positive_regulation EPHB2 EPX 25374571 914990 Positive_regulation EPHB2 ERAS 18004277 1902510 Positive_regulation EPHB2 ERBB2 10648571 1255617 Positive_regulation EPHB2 ERBB2 15210733 1310106 Positive_regulation EPHB2 ERBB2 19855434 2127659 Positive_regulation EPHB2 ERBB2 20711231 2133591 Positive_regulation EPHB2 ERBB2 20711231 2133638 Positive_regulation EPHB2 ERBB2 20711231 2133667 Positive_regulation EPHB2 ERBB2 21278786 2137742 Positive_regulation EPHB2 ERBB2 21278786 2137743 Positive_regulation EPHB2 ERBB2 21278786 2137744 Positive_regulation EPHB2 ERBB2 21595894 467798 Positive_regulation EPHB2 ERBB2 21708009 260354 Positive_regulation EPHB2 ERBB2 21847121 437650 Positive_regulation EPHB2 ERBB2 21847121 437669 Positive_regulation EPHB2 ERBB2 22988345 1750577 Positive_regulation EPHB2 ERBB2 23369183 472824 Positive_regulation EPHB2 ERBB2 23369183 472833 Positive_regulation EPHB2 ERBB2 23369183 472839 Positive_regulation EPHB2 ERBB2 23803171 536508 Positive_regulation EPHB2 ERBB2 24009853 203863 Positive_regulation EPHB2 ERBB2 25221644 987067 Positive_regulation EPHB2 ERBB3 21847121 437651 Positive_regulation EPHB2 ERBB3 21847121 437670 Positive_regulation EPHB2 ERBB3 22768204 2660106 Positive_regulation EPHB2 ERBB3 23803171 536509 Positive_regulation EPHB2 ERBB3 25400118 2207131 Positive_regulation EPHB2 ERBB4 25177687 198453 Positive_regulation EPHB2 ERF 23527098 2769384 Positive_regulation EPHB2 ERF 23583981 1951404 Positive_regulation EPHB2 ERG 24504051 2187043 Positive_regulation EPHB2 ERVK-6 24860547 880613 Positive_regulation EPHB2 ETS1 21711453 2252492 Positive_regulation EPHB2 ETS1 24968297 2984149 Positive_regulation EPHB2 ETS1 25294825 2105154 Positive_regulation EPHB2 ETS1 25294825 2105155 Positive_regulation EPHB2 ETS1 25294825 2105186 Positive_regulation EPHB2 ETS1 25294825 2105197 Positive_regulation EPHB2 ETS1 25294825 2105202 Positive_regulation EPHB2 ETS2 24968297 2984150 Positive_regulation EPHB2 ETS2 25294825 2105156 Positive_regulation EPHB2 F2R 24743392 2955198 Positive_regulation EPHB2 F2R 24743392 2955330 Positive_regulation EPHB2 F2R 24743392 2955404 Positive_regulation EPHB2 F2RL1 22954301 1626674 Positive_regulation EPHB2 F2RL1 24084727 1113085 Positive_regulation EPHB2 F2RL1 24551046 2922769 Positive_regulation EPHB2 F2RL1 24860547 880597 Positive_regulation EPHB2 FAIM 15520226 1316196 Positive_regulation EPHB2 FAS 11121444 1265876 Positive_regulation EPHB2 FAS 15795317 1319324 Positive_regulation EPHB2 FAS 22046349 2566526 Positive_regulation EPHB2 FAS 23029562 2698762 Positive_regulation EPHB2 FAS 23412386 559945 Positive_regulation EPHB2 FAS 25068294 2992765 Positive_regulation EPHB2 FASLG 22247744 639743 Positive_regulation EPHB2 FASLG 23412386 559946 Positive_regulation EPHB2 FASLG 23598406 561396 Positive_regulation EPHB2 FBXW11 12177047 1286328 Positive_regulation EPHB2 FBXW11 12177047 1286329 Positive_regulation EPHB2 FBXW11 12177047 1286365 Positive_regulation EPHB2 FCGR3B 8551221 1595778 Positive_regulation EPHB2 FCN2 24586980 2928634 Positive_regulation EPHB2 FFAR4 18769551 3074585 Positive_regulation EPHB2 FGB 11121444 1265885 Positive_regulation EPHB2 FGF1 11449001 1272993 Positive_regulation EPHB2 FGF1 11449001 1272994 Positive_regulation EPHB2 FGF1 11449001 1272995 Positive_regulation EPHB2 FGF1 11449001 1272996 Positive_regulation EPHB2 FGF1 11449001 1272997 Positive_regulation EPHB2 FGF1 11449001 1273085 Positive_regulation EPHB2 FGF1 11449001 1273196 Positive_regulation EPHB2 FGF1 11449001 1273218 Positive_regulation EPHB2 FGF1 11449001 1273219 Positive_regulation EPHB2 FGF1 11449001 1273220 Positive_regulation EPHB2 FGF1 11449001 1273350 Positive_regulation EPHB2 FGF1 11449001 1273373 Positive_regulation EPHB2 FGF1 12952943 1296734 Positive_regulation EPHB2 FGF1 15630138 1534074 Positive_regulation EPHB2 FGF1 16009726 1321424 Positive_regulation EPHB2 FGF1 17553162 300208 Positive_regulation EPHB2 FGF1 18335055 2387128 Positive_regulation EPHB2 FGF1 19333377 2409556 Positive_regulation EPHB2 FGF1 19888221 433906 Positive_regulation EPHB2 FGF1 20422052 2447880 Positive_regulation EPHB2 FGF1 20652960 3170785 Positive_regulation EPHB2 FGF1 20652960 3170901 Positive_regulation EPHB2 FGF1 21048967 2480265 Positive_regulation EPHB2 FGF1 21152424 2486369 Positive_regulation EPHB2 FGF1 21364986 2504725 Positive_regulation EPHB2 FGF1 21364986 2504775 Positive_regulation EPHB2 FGF1 21816365 615291 Positive_regulation EPHB2 FGF1 21902831 3160635 Positive_regulation EPHB2 FGF1 22078327 261790 Positive_regulation EPHB2 FGF1 22078327 261794 Positive_regulation EPHB2 FGF1 22235335 2585915 Positive_regulation EPHB2 FGF1 22298785 1201028 Positive_regulation EPHB2 FGF1 23226437 2724797 Positive_regulation EPHB2 FGF1 24550718 2300024 Positive_regulation EPHB2 FGF1 24744103 494678 Positive_regulation EPHB2 FGF1 24744103 494899 Positive_regulation EPHB2 FGF1 24744103 494931 Positive_regulation EPHB2 FGF1 24744103 494998 Positive_regulation EPHB2 FGF1 24744103 495022 Positive_regulation EPHB2 FGF1 24824078 2969146 Positive_regulation EPHB2 FGF1 25171101 3004199 Positive_regulation EPHB2 FGF1 25514808 3034813 Positive_regulation EPHB2 FGF1 25526563 1136095 Positive_regulation EPHB2 FGF10 11449001 1272998 Positive_regulation EPHB2 FGF10 11449001 1272999 Positive_regulation EPHB2 FGF10 11449001 1273000 Positive_regulation EPHB2 FGF10 11449001 1273001 Positive_regulation EPHB2 FGF10 11449001 1273002 Positive_regulation EPHB2 FGF10 11449001 1273003 Positive_regulation EPHB2 FGF10 11449001 1273086 Positive_regulation EPHB2 FGF10 11449001 1273197 Positive_regulation EPHB2 FGF10 11449001 1273221 Positive_regulation EPHB2 FGF10 11449001 1273222 Positive_regulation EPHB2 FGF10 11449001 1273223 Positive_regulation EPHB2 FGF10 11449001 1273351 Positive_regulation EPHB2 FGF10 11449001 1273374 Positive_regulation EPHB2 FGF10 12952943 1296735 Positive_regulation EPHB2 FGF10 15630138 1534075 Positive_regulation EPHB2 FGF10 15972105 298225 Positive_regulation EPHB2 FGF10 17553162 300209 Positive_regulation EPHB2 FGF10 18335055 2387129 Positive_regulation EPHB2 FGF10 19333377 2409557 Positive_regulation EPHB2 FGF10 19888221 433907 Positive_regulation EPHB2 FGF10 20422052 2447881 Positive_regulation EPHB2 FGF10 20652960 3170786 Positive_regulation EPHB2 FGF10 20652960 3170902 Positive_regulation EPHB2 FGF10 21048967 2480266 Positive_regulation EPHB2 FGF10 21152424 2486370 Positive_regulation EPHB2 FGF10 21364986 2504726 Positive_regulation EPHB2 FGF10 21364986 2504776 Positive_regulation EPHB2 FGF10 21816365 615292 Positive_regulation EPHB2 FGF10 21902831 3160636 Positive_regulation EPHB2 FGF10 22078327 261795 Positive_regulation EPHB2 FGF10 22235335 2585916 Positive_regulation EPHB2 FGF10 22298785 1201029 Positive_regulation EPHB2 FGF10 22737238 2655711 Positive_regulation EPHB2 FGF10 23226437 2724798 Positive_regulation EPHB2 FGF10 24550718 2300025 Positive_regulation EPHB2 FGF10 24744103 494679 Positive_regulation EPHB2 FGF10 24744103 494900 Positive_regulation EPHB2 FGF10 24744103 494932 Positive_regulation EPHB2 FGF10 24744103 494999 Positive_regulation EPHB2 FGF10 24744103 495023 Positive_regulation EPHB2 FGF10 24824078 2969147 Positive_regulation EPHB2 FGF10 25171101 3004200 Positive_regulation EPHB2 FGF10 25514808 3034814 Positive_regulation EPHB2 FGF10 25526563 1136096 Positive_regulation EPHB2 FGF11 11449001 1273004 Positive_regulation EPHB2 FGF11 11449001 1273005 Positive_regulation EPHB2 FGF11 11449001 1273006 Positive_regulation EPHB2 FGF11 11449001 1273007 Positive_regulation EPHB2 FGF11 11449001 1273087 Positive_regulation EPHB2 FGF11 11449001 1273198 Positive_regulation EPHB2 FGF11 11449001 1273224 Positive_regulation EPHB2 FGF11 11449001 1273225 Positive_regulation EPHB2 FGF11 11449001 1273226 Positive_regulation EPHB2 FGF11 11449001 1273352 Positive_regulation EPHB2 FGF11 11449001 1273375 Positive_regulation EPHB2 FGF11 12952943 1296736 Positive_regulation EPHB2 FGF11 15630138 1534076 Positive_regulation EPHB2 FGF11 17553162 300210 Positive_regulation EPHB2 FGF11 18335055 2387130 Positive_regulation EPHB2 FGF11 19333377 2409558 Positive_regulation EPHB2 FGF11 19888221 433908 Positive_regulation EPHB2 FGF11 20422052 2447882 Positive_regulation EPHB2 FGF11 20652960 3170787 Positive_regulation EPHB2 FGF11 20652960 3170903 Positive_regulation EPHB2 FGF11 21048967 2480267 Positive_regulation EPHB2 FGF11 21152424 2486371 Positive_regulation EPHB2 FGF11 21364986 2504727 Positive_regulation EPHB2 FGF11 21364986 2504777 Positive_regulation EPHB2 FGF11 21816365 615293 Positive_regulation EPHB2 FGF11 21902831 3160637 Positive_regulation EPHB2 FGF11 22078327 261796 Positive_regulation EPHB2 FGF11 22235335 2585917 Positive_regulation EPHB2 FGF11 22298785 1201030 Positive_regulation EPHB2 FGF11 23226437 2724799 Positive_regulation EPHB2 FGF11 24550718 2300026 Positive_regulation EPHB2 FGF11 24744103 494680 Positive_regulation EPHB2 FGF11 24744103 494901 Positive_regulation EPHB2 FGF11 24744103 494933 Positive_regulation EPHB2 FGF11 24744103 495000 Positive_regulation EPHB2 FGF11 24744103 495024 Positive_regulation EPHB2 FGF11 24824078 2969148 Positive_regulation EPHB2 FGF11 25171101 3004201 Positive_regulation EPHB2 FGF11 25514808 3034815 Positive_regulation EPHB2 FGF11 25526563 1136097 Positive_regulation EPHB2 FGF12 11449001 1273008 Positive_regulation EPHB2 FGF12 11449001 1273009 Positive_regulation EPHB2 FGF12 11449001 1273010 Positive_regulation EPHB2 FGF12 11449001 1273011 Positive_regulation EPHB2 FGF12 11449001 1273088 Positive_regulation EPHB2 FGF12 11449001 1273199 Positive_regulation EPHB2 FGF12 11449001 1273227 Positive_regulation EPHB2 FGF12 11449001 1273228 Positive_regulation EPHB2 FGF12 11449001 1273229 Positive_regulation EPHB2 FGF12 11449001 1273353 Positive_regulation EPHB2 FGF12 11449001 1273376 Positive_regulation EPHB2 FGF12 12952943 1296737 Positive_regulation EPHB2 FGF12 15630138 1534077 Positive_regulation EPHB2 FGF12 17553162 300211 Positive_regulation EPHB2 FGF12 18335055 2387131 Positive_regulation EPHB2 FGF12 19333377 2409559 Positive_regulation EPHB2 FGF12 19888221 433909 Positive_regulation EPHB2 FGF12 20422052 2447883 Positive_regulation EPHB2 FGF12 20652960 3170788 Positive_regulation EPHB2 FGF12 20652960 3170904 Positive_regulation EPHB2 FGF12 21048967 2480268 Positive_regulation EPHB2 FGF12 21152424 2486372 Positive_regulation EPHB2 FGF12 21364986 2504728 Positive_regulation EPHB2 FGF12 21364986 2504778 Positive_regulation EPHB2 FGF12 21816365 615294 Positive_regulation EPHB2 FGF12 21902831 3160638 Positive_regulation EPHB2 FGF12 22078327 261797 Positive_regulation EPHB2 FGF12 22235335 2585918 Positive_regulation EPHB2 FGF12 22298785 1201031 Positive_regulation EPHB2 FGF12 23226437 2724800 Positive_regulation EPHB2 FGF12 24550718 2300027 Positive_regulation EPHB2 FGF12 24744103 494681 Positive_regulation EPHB2 FGF12 24744103 494902 Positive_regulation EPHB2 FGF12 24744103 494934 Positive_regulation EPHB2 FGF12 24744103 495001 Positive_regulation EPHB2 FGF12 24744103 495025 Positive_regulation EPHB2 FGF12 24824078 2969149 Positive_regulation EPHB2 FGF12 25171101 3004202 Positive_regulation EPHB2 FGF12 25514808 3034816 Positive_regulation EPHB2 FGF12 25526563 1136098 Positive_regulation EPHB2 FGF13 11449001 1273012 Positive_regulation EPHB2 FGF13 11449001 1273013 Positive_regulation EPHB2 FGF13 11449001 1273014 Positive_regulation EPHB2 FGF13 11449001 1273015 Positive_regulation EPHB2 FGF13 11449001 1273089 Positive_regulation EPHB2 FGF13 11449001 1273200 Positive_regulation EPHB2 FGF13 11449001 1273230 Positive_regulation EPHB2 FGF13 11449001 1273231 Positive_regulation EPHB2 FGF13 11449001 1273232 Positive_regulation EPHB2 FGF13 11449001 1273354 Positive_regulation EPHB2 FGF13 11449001 1273377 Positive_regulation EPHB2 FGF13 12952943 1296738 Positive_regulation EPHB2 FGF13 15630138 1534078 Positive_regulation EPHB2 FGF13 17553162 300212 Positive_regulation EPHB2 FGF13 18335055 2387132 Positive_regulation EPHB2 FGF13 19333377 2409560 Positive_regulation EPHB2 FGF13 19888221 433910 Positive_regulation EPHB2 FGF13 20422052 2447884 Positive_regulation EPHB2 FGF13 20652960 3170789 Positive_regulation EPHB2 FGF13 20652960 3170905 Positive_regulation EPHB2 FGF13 21048967 2480269 Positive_regulation EPHB2 FGF13 21152424 2486373 Positive_regulation EPHB2 FGF13 21364986 2504729 Positive_regulation EPHB2 FGF13 21364986 2504779 Positive_regulation EPHB2 FGF13 21816365 615295 Positive_regulation EPHB2 FGF13 21902831 3160639 Positive_regulation EPHB2 FGF13 22078327 261798 Positive_regulation EPHB2 FGF13 22235335 2585919 Positive_regulation EPHB2 FGF13 22298785 1201032 Positive_regulation EPHB2 FGF13 23226437 2724801 Positive_regulation EPHB2 FGF13 24550718 2300028 Positive_regulation EPHB2 FGF13 24744103 494682 Positive_regulation EPHB2 FGF13 24744103 494903 Positive_regulation EPHB2 FGF13 24744103 494935 Positive_regulation EPHB2 FGF13 24744103 495002 Positive_regulation EPHB2 FGF13 24744103 495026 Positive_regulation EPHB2 FGF13 24824078 2969150 Positive_regulation EPHB2 FGF13 25171101 3004203 Positive_regulation EPHB2 FGF13 25514808 3034817 Positive_regulation EPHB2 FGF13 25526563 1136099 Positive_regulation EPHB2 FGF14 11449001 1273016 Positive_regulation EPHB2 FGF14 11449001 1273017 Positive_regulation EPHB2 FGF14 11449001 1273018 Positive_regulation EPHB2 FGF14 11449001 1273019 Positive_regulation EPHB2 FGF14 11449001 1273090 Positive_regulation EPHB2 FGF14 11449001 1273201 Positive_regulation EPHB2 FGF14 11449001 1273233 Positive_regulation EPHB2 FGF14 11449001 1273234 Positive_regulation EPHB2 FGF14 11449001 1273235 Positive_regulation EPHB2 FGF14 11449001 1273355 Positive_regulation EPHB2 FGF14 11449001 1273378 Positive_regulation EPHB2 FGF14 12952943 1296739 Positive_regulation EPHB2 FGF14 15630138 1534079 Positive_regulation EPHB2 FGF14 17553162 300213 Positive_regulation EPHB2 FGF14 18335055 2387133 Positive_regulation EPHB2 FGF14 19333377 2409561 Positive_regulation EPHB2 FGF14 19888221 433911 Positive_regulation EPHB2 FGF14 20422052 2447885 Positive_regulation EPHB2 FGF14 20652960 3170790 Positive_regulation EPHB2 FGF14 20652960 3170906 Positive_regulation EPHB2 FGF14 21048967 2480270 Positive_regulation EPHB2 FGF14 21152424 2486374 Positive_regulation EPHB2 FGF14 21364986 2504730 Positive_regulation EPHB2 FGF14 21364986 2504780 Positive_regulation EPHB2 FGF14 21816365 615296 Positive_regulation EPHB2 FGF14 21902831 3160640 Positive_regulation EPHB2 FGF14 22078327 261799 Positive_regulation EPHB2 FGF14 22235335 2585920 Positive_regulation EPHB2 FGF14 22298785 1201033 Positive_regulation EPHB2 FGF14 23226437 2724802 Positive_regulation EPHB2 FGF14 24550718 2300029 Positive_regulation EPHB2 FGF14 24744103 494683 Positive_regulation EPHB2 FGF14 24744103 494904 Positive_regulation EPHB2 FGF14 24744103 494936 Positive_regulation EPHB2 FGF14 24744103 495003 Positive_regulation EPHB2 FGF14 24744103 495027 Positive_regulation EPHB2 FGF14 24824078 2969151 Positive_regulation EPHB2 FGF14 25171101 3004204 Positive_regulation EPHB2 FGF14 25514808 3034818 Positive_regulation EPHB2 FGF14 25526563 1136100 Positive_regulation EPHB2 FGF16 11449001 1273020 Positive_regulation EPHB2 FGF16 11449001 1273021 Positive_regulation EPHB2 FGF16 11449001 1273022 Positive_regulation EPHB2 FGF16 11449001 1273023 Positive_regulation EPHB2 FGF16 11449001 1273091 Positive_regulation EPHB2 FGF16 11449001 1273202 Positive_regulation EPHB2 FGF16 11449001 1273236 Positive_regulation EPHB2 FGF16 11449001 1273237 Positive_regulation EPHB2 FGF16 11449001 1273238 Positive_regulation EPHB2 FGF16 11449001 1273356 Positive_regulation EPHB2 FGF16 11449001 1273379 Positive_regulation EPHB2 FGF16 12952943 1296740 Positive_regulation EPHB2 FGF16 15630138 1534080 Positive_regulation EPHB2 FGF16 17553162 300214 Positive_regulation EPHB2 FGF16 18335055 2387134 Positive_regulation EPHB2 FGF16 19333377 2409562 Positive_regulation EPHB2 FGF16 19888221 433912 Positive_regulation EPHB2 FGF16 20422052 2447886 Positive_regulation EPHB2 FGF16 20652960 3170791 Positive_regulation EPHB2 FGF16 20652960 3170907 Positive_regulation EPHB2 FGF16 21048967 2480271 Positive_regulation EPHB2 FGF16 21152424 2486375 Positive_regulation EPHB2 FGF16 21364986 2504731 Positive_regulation EPHB2 FGF16 21364986 2504781 Positive_regulation EPHB2 FGF16 21816365 615297 Positive_regulation EPHB2 FGF16 21902831 3160641 Positive_regulation EPHB2 FGF16 22078327 261800 Positive_regulation EPHB2 FGF16 22235335 2585921 Positive_regulation EPHB2 FGF16 22298785 1201034 Positive_regulation EPHB2 FGF16 23226437 2724803 Positive_regulation EPHB2 FGF16 24550718 2300030 Positive_regulation EPHB2 FGF16 24744103 494684 Positive_regulation EPHB2 FGF16 24744103 494905 Positive_regulation EPHB2 FGF16 24744103 494937 Positive_regulation EPHB2 FGF16 24744103 495004 Positive_regulation EPHB2 FGF16 24744103 495028 Positive_regulation EPHB2 FGF16 24824078 2969152 Positive_regulation EPHB2 FGF16 25171101 3004205 Positive_regulation EPHB2 FGF16 25514808 3034819 Positive_regulation EPHB2 FGF16 25526563 1136101 Positive_regulation EPHB2 FGF17 11449001 1273024 Positive_regulation EPHB2 FGF17 11449001 1273025 Positive_regulation EPHB2 FGF17 11449001 1273026 Positive_regulation EPHB2 FGF17 11449001 1273027 Positive_regulation EPHB2 FGF17 11449001 1273092 Positive_regulation EPHB2 FGF17 11449001 1273203 Positive_regulation EPHB2 FGF17 11449001 1273239 Positive_regulation EPHB2 FGF17 11449001 1273240 Positive_regulation EPHB2 FGF17 11449001 1273241 Positive_regulation EPHB2 FGF17 11449001 1273357 Positive_regulation EPHB2 FGF17 11449001 1273380 Positive_regulation EPHB2 FGF17 12952943 1296741 Positive_regulation EPHB2 FGF17 15630138 1534081 Positive_regulation EPHB2 FGF17 17553162 300215 Positive_regulation EPHB2 FGF17 18335055 2387135 Positive_regulation EPHB2 FGF17 19333377 2409563 Positive_regulation EPHB2 FGF17 19888221 433913 Positive_regulation EPHB2 FGF17 20422052 2447887 Positive_regulation EPHB2 FGF17 20652960 3170792 Positive_regulation EPHB2 FGF17 20652960 3170908 Positive_regulation EPHB2 FGF17 21048967 2480272 Positive_regulation EPHB2 FGF17 21152424 2486376 Positive_regulation EPHB2 FGF17 21364986 2504732 Positive_regulation EPHB2 FGF17 21364986 2504782 Positive_regulation EPHB2 FGF17 21816365 615298 Positive_regulation EPHB2 FGF17 21902831 3160642 Positive_regulation EPHB2 FGF17 22078327 261801 Positive_regulation EPHB2 FGF17 22235335 2585922 Positive_regulation EPHB2 FGF17 22298785 1201035 Positive_regulation EPHB2 FGF17 23226437 2724804 Positive_regulation EPHB2 FGF17 24550718 2300031 Positive_regulation EPHB2 FGF17 24744103 494685 Positive_regulation EPHB2 FGF17 24744103 494906 Positive_regulation EPHB2 FGF17 24744103 494938 Positive_regulation EPHB2 FGF17 24744103 495005 Positive_regulation EPHB2 FGF17 24744103 495029 Positive_regulation EPHB2 FGF17 24824078 2969153 Positive_regulation EPHB2 FGF17 25171101 3004206 Positive_regulation EPHB2 FGF17 25514808 3034820 Positive_regulation EPHB2 FGF17 25526563 1136102 Positive_regulation EPHB2 FGF18 11449001 1273028 Positive_regulation EPHB2 FGF18 11449001 1273029 Positive_regulation EPHB2 FGF18 11449001 1273030 Positive_regulation EPHB2 FGF18 11449001 1273031 Positive_regulation EPHB2 FGF18 11449001 1273093 Positive_regulation EPHB2 FGF18 11449001 1273204 Positive_regulation EPHB2 FGF18 11449001 1273242 Positive_regulation EPHB2 FGF18 11449001 1273243 Positive_regulation EPHB2 FGF18 11449001 1273244 Positive_regulation EPHB2 FGF18 11449001 1273358 Positive_regulation EPHB2 FGF18 11449001 1273381 Positive_regulation EPHB2 FGF18 12952943 1296742 Positive_regulation EPHB2 FGF18 15630138 1534082 Positive_regulation EPHB2 FGF18 17553162 300216 Positive_regulation EPHB2 FGF18 18335055 2387136 Positive_regulation EPHB2 FGF18 19333377 2409564 Positive_regulation EPHB2 FGF18 19888221 433914 Positive_regulation EPHB2 FGF18 20422052 2447888 Positive_regulation EPHB2 FGF18 20652960 3170793 Positive_regulation EPHB2 FGF18 20652960 3170909 Positive_regulation EPHB2 FGF18 21048967 2480273 Positive_regulation EPHB2 FGF18 21152424 2486377 Positive_regulation EPHB2 FGF18 21364986 2504733 Positive_regulation EPHB2 FGF18 21364986 2504783 Positive_regulation EPHB2 FGF18 21816365 615299 Positive_regulation EPHB2 FGF18 21902831 3160643 Positive_regulation EPHB2 FGF18 22078327 261802 Positive_regulation EPHB2 FGF18 22235335 2585923 Positive_regulation EPHB2 FGF18 22298785 1201036 Positive_regulation EPHB2 FGF18 23226437 2724805 Positive_regulation EPHB2 FGF18 24550718 2300032 Positive_regulation EPHB2 FGF18 24744103 494686 Positive_regulation EPHB2 FGF18 24744103 494907 Positive_regulation EPHB2 FGF18 24744103 494939 Positive_regulation EPHB2 FGF18 24744103 495006 Positive_regulation EPHB2 FGF18 24744103 495030 Positive_regulation EPHB2 FGF18 24824078 2969154 Positive_regulation EPHB2 FGF18 25171101 3004207 Positive_regulation EPHB2 FGF18 25514808 3034821 Positive_regulation EPHB2 FGF18 25526563 1136103 Positive_regulation EPHB2 FGF19 11449001 1273032 Positive_regulation EPHB2 FGF19 11449001 1273033 Positive_regulation EPHB2 FGF19 11449001 1273034 Positive_regulation EPHB2 FGF19 11449001 1273035 Positive_regulation EPHB2 FGF19 11449001 1273094 Positive_regulation EPHB2 FGF19 11449001 1273205 Positive_regulation EPHB2 FGF19 11449001 1273245 Positive_regulation EPHB2 FGF19 11449001 1273246 Positive_regulation EPHB2 FGF19 11449001 1273247 Positive_regulation EPHB2 FGF19 11449001 1273359 Positive_regulation EPHB2 FGF19 11449001 1273382 Positive_regulation EPHB2 FGF19 12952943 1296743 Positive_regulation EPHB2 FGF19 15630138 1534083 Positive_regulation EPHB2 FGF19 17553162 300217 Positive_regulation EPHB2 FGF19 18335055 2387137 Positive_regulation EPHB2 FGF19 19333377 2409565 Positive_regulation EPHB2 FGF19 19888221 433915 Positive_regulation EPHB2 FGF19 20422052 2447889 Positive_regulation EPHB2 FGF19 20652960 3170794 Positive_regulation EPHB2 FGF19 20652960 3170910 Positive_regulation EPHB2 FGF19 21048967 2480274 Positive_regulation EPHB2 FGF19 21152424 2486378 Positive_regulation EPHB2 FGF19 21364986 2504734 Positive_regulation EPHB2 FGF19 21364986 2504784 Positive_regulation EPHB2 FGF19 21816365 615300 Positive_regulation EPHB2 FGF19 21902831 3160644 Positive_regulation EPHB2 FGF19 22078327 261803 Positive_regulation EPHB2 FGF19 22235335 2585924 Positive_regulation EPHB2 FGF19 22298785 1201037 Positive_regulation EPHB2 FGF19 23226437 2724806 Positive_regulation EPHB2 FGF19 24550718 2300033 Positive_regulation EPHB2 FGF19 24744103 494687 Positive_regulation EPHB2 FGF19 24744103 494908 Positive_regulation EPHB2 FGF19 24744103 494940 Positive_regulation EPHB2 FGF19 24744103 495007 Positive_regulation EPHB2 FGF19 24744103 495031 Positive_regulation EPHB2 FGF19 24824078 2969155 Positive_regulation EPHB2 FGF19 25171101 3004208 Positive_regulation EPHB2 FGF19 25514808 3034822 Positive_regulation EPHB2 FGF19 25526563 1136104 Positive_regulation EPHB2 FGF2 11449001 1273036 Positive_regulation EPHB2 FGF2 11449001 1273037 Positive_regulation EPHB2 FGF2 11449001 1273038 Positive_regulation EPHB2 FGF2 11449001 1273039 Positive_regulation EPHB2 FGF2 11449001 1273095 Positive_regulation EPHB2 FGF2 11449001 1273206 Positive_regulation EPHB2 FGF2 11449001 1273248 Positive_regulation EPHB2 FGF2 11449001 1273249 Positive_regulation EPHB2 FGF2 11449001 1273250 Positive_regulation EPHB2 FGF2 11449001 1273360 Positive_regulation EPHB2 FGF2 11449001 1273383 Positive_regulation EPHB2 FGF2 12069692 225068 Positive_regulation EPHB2 FGF2 12952943 1296744 Positive_regulation EPHB2 FGF2 12952943 1296745 Positive_regulation EPHB2 FGF2 12952943 1296746 Positive_regulation EPHB2 FGF2 12952943 1296777 Positive_regulation EPHB2 FGF2 12952943 1296782 Positive_regulation EPHB2 FGF2 12952943 1296799 Positive_regulation EPHB2 FGF2 12952943 1296805 Positive_regulation EPHB2 FGF2 15630138 1534084 Positive_regulation EPHB2 FGF2 15689238 382672 Positive_regulation EPHB2 FGF2 15689238 382673 Positive_regulation EPHB2 FGF2 15689238 382691 Positive_regulation EPHB2 FGF2 16009726 1321410 Positive_regulation EPHB2 FGF2 16009726 1321411 Positive_regulation EPHB2 FGF2 16009726 1321432 Positive_regulation EPHB2 FGF2 17553162 300218 Positive_regulation EPHB2 FGF2 18335055 2387138 Positive_regulation EPHB2 FGF2 18404483 3087988 Positive_regulation EPHB2 FGF2 19333377 2409566 Positive_regulation EPHB2 FGF2 19888221 433916 Positive_regulation EPHB2 FGF2 20422052 2447890 Positive_regulation EPHB2 FGF2 20652960 3170651 Positive_regulation EPHB2 FGF2 20652960 3170795 Positive_regulation EPHB2 FGF2 20652960 3170822 Positive_regulation EPHB2 FGF2 20652960 3170839 Positive_regulation EPHB2 FGF2 20652960 3170893 Positive_regulation EPHB2 FGF2 20652960 3170894 Positive_regulation EPHB2 FGF2 20652960 3170911 Positive_regulation EPHB2 FGF2 20657775 2456441 Positive_regulation EPHB2 FGF2 20657775 2456442 Positive_regulation EPHB2 FGF2 20813052 1858494 Positive_regulation EPHB2 FGF2 20886037 2476107 Positive_regulation EPHB2 FGF2 21037797 2301678 Positive_regulation EPHB2 FGF2 21037797 2301679 Positive_regulation EPHB2 FGF2 21048967 2480275 Positive_regulation EPHB2 FGF2 21152424 2486329 Positive_regulation EPHB2 FGF2 21152424 2486379 Positive_regulation EPHB2 FGF2 21224849 768983 Positive_regulation EPHB2 FGF2 21224849 769088 Positive_regulation EPHB2 FGF2 21224849 769117 Positive_regulation EPHB2 FGF2 21364986 2504735 Positive_regulation EPHB2 FGF2 21364986 2504785 Positive_regulation EPHB2 FGF2 21720547 2531611 Positive_regulation EPHB2 FGF2 21720547 2531612 Positive_regulation EPHB2 FGF2 21720547 2531613 Positive_regulation EPHB2 FGF2 21816365 615301 Positive_regulation EPHB2 FGF2 21902831 3160645 Positive_regulation EPHB2 FGF2 21906308 1505535 Positive_regulation EPHB2 FGF2 22078327 261791 Positive_regulation EPHB2 FGF2 22078327 261804 Positive_regulation EPHB2 FGF2 22235335 2585925 Positive_regulation EPHB2 FGF2 22294553 777954 Positive_regulation EPHB2 FGF2 22298785 1201038 Positive_regulation EPHB2 FGF2 22298785 1201039 Positive_regulation EPHB2 FGF2 22363548 2599999 Positive_regulation EPHB2 FGF2 22761819 2658576 Positive_regulation EPHB2 FGF2 23226437 2724807 Positive_regulation EPHB2 FGF2 23349801 2743220 Positive_regulation EPHB2 FGF2 23554919 2774046 Positive_regulation EPHB2 FGF2 23740825 135572 Positive_regulation EPHB2 FGF2 23793469 31282 Positive_regulation EPHB2 FGF2 23864770 1754272 Positive_regulation EPHB2 FGF2 23967228 2835088 Positive_regulation EPHB2 FGF2 24324705 2891127 Positive_regulation EPHB2 FGF2 24550718 2300034 Positive_regulation EPHB2 FGF2 24649403 853700 Positive_regulation EPHB2 FGF2 24735639 1668070 Positive_regulation EPHB2 FGF2 24735639 1668071 Positive_regulation EPHB2 FGF2 24744103 494688 Positive_regulation EPHB2 FGF2 24744103 494909 Positive_regulation EPHB2 FGF2 24744103 494941 Positive_regulation EPHB2 FGF2 24744103 495008 Positive_regulation EPHB2 FGF2 24744103 495032 Positive_regulation EPHB2 FGF2 24824078 2969156 Positive_regulation EPHB2 FGF2 24848261 2972374 Positive_regulation EPHB2 FGF2 24970807 2193931 Positive_regulation EPHB2 FGF2 24980830 2194853 Positive_regulation EPHB2 FGF2 25093198 3156796 Positive_regulation EPHB2 FGF2 25171101 3004209 Positive_regulation EPHB2 FGF2 25295214 1692974 Positive_regulation EPHB2 FGF2 25369078 3022213 Positive_regulation EPHB2 FGF2 25426952 3030354 Positive_regulation EPHB2 FGF2 25514808 3034823 Positive_regulation EPHB2 FGF2 25526563 1136105 Positive_regulation EPHB2 FGF2 9490736 1466642 Positive_regulation EPHB2 FGF2 9490736 1466643 Positive_regulation EPHB2 FGF2 9490736 1466644 Positive_regulation EPHB2 FGF2 9490736 1466645 Positive_regulation EPHB2 FGF2 9490736 1466646 Positive_regulation EPHB2 FGF2 9490736 1466647 Positive_regulation EPHB2 FGF2 PMC2750791 450273 Positive_regulation EPHB2 FGF20 11449001 1273040 Positive_regulation EPHB2 FGF20 11449001 1273041 Positive_regulation EPHB2 FGF20 11449001 1273042 Positive_regulation EPHB2 FGF20 11449001 1273043 Positive_regulation EPHB2 FGF20 11449001 1273096 Positive_regulation EPHB2 FGF20 11449001 1273207 Positive_regulation EPHB2 FGF20 11449001 1273251 Positive_regulation EPHB2 FGF20 11449001 1273252 Positive_regulation EPHB2 FGF20 11449001 1273253 Positive_regulation EPHB2 FGF20 11449001 1273361 Positive_regulation EPHB2 FGF20 11449001 1273384 Positive_regulation EPHB2 FGF20 12952943 1296747 Positive_regulation EPHB2 FGF20 15630138 1534085 Positive_regulation EPHB2 FGF20 17553162 300219 Positive_regulation EPHB2 FGF20 18335055 2387139 Positive_regulation EPHB2 FGF20 19333377 2409567 Positive_regulation EPHB2 FGF20 19888221 433917 Positive_regulation EPHB2 FGF20 20422052 2447891 Positive_regulation EPHB2 FGF20 20652960 3170796 Positive_regulation EPHB2 FGF20 20652960 3170912 Positive_regulation EPHB2 FGF20 21048967 2480276 Positive_regulation EPHB2 FGF20 21152424 2486380 Positive_regulation EPHB2 FGF20 21364986 2504736 Positive_regulation EPHB2 FGF20 21364986 2504786 Positive_regulation EPHB2 FGF20 21816365 615302 Positive_regulation EPHB2 FGF20 21902831 3160646 Positive_regulation EPHB2 FGF20 22078327 261805 Positive_regulation EPHB2 FGF20 22235335 2585926 Positive_regulation EPHB2 FGF20 22298785 1201040 Positive_regulation EPHB2 FGF20 23226437 2724808 Positive_regulation EPHB2 FGF20 24550718 2300035 Positive_regulation EPHB2 FGF20 24744103 494689 Positive_regulation EPHB2 FGF20 24744103 494910 Positive_regulation EPHB2 FGF20 24744103 494942 Positive_regulation EPHB2 FGF20 24744103 495009 Positive_regulation EPHB2 FGF20 24744103 495033 Positive_regulation EPHB2 FGF20 24824078 2969157 Positive_regulation EPHB2 FGF20 25171101 3004210 Positive_regulation EPHB2 FGF20 25514808 3034824 Positive_regulation EPHB2 FGF20 25526563 1136106 Positive_regulation EPHB2 FGF21 11449001 1273044 Positive_regulation EPHB2 FGF21 11449001 1273045 Positive_regulation EPHB2 FGF21 11449001 1273046 Positive_regulation EPHB2 FGF21 11449001 1273047 Positive_regulation EPHB2 FGF21 11449001 1273097 Positive_regulation EPHB2 FGF21 11449001 1273208 Positive_regulation EPHB2 FGF21 11449001 1273254 Positive_regulation EPHB2 FGF21 11449001 1273255 Positive_regulation EPHB2 FGF21 11449001 1273256 Positive_regulation EPHB2 FGF21 11449001 1273362 Positive_regulation EPHB2 FGF21 11449001 1273385 Positive_regulation EPHB2 FGF21 12952943 1296748 Positive_regulation EPHB2 FGF21 15630138 1534086 Positive_regulation EPHB2 FGF21 17553162 300220 Positive_regulation EPHB2 FGF21 18335055 2387140 Positive_regulation EPHB2 FGF21 19333377 2409568 Positive_regulation EPHB2 FGF21 19888221 433918 Positive_regulation EPHB2 FGF21 20422052 2447892 Positive_regulation EPHB2 FGF21 20652960 3170797 Positive_regulation EPHB2 FGF21 20652960 3170913 Positive_regulation EPHB2 FGF21 21048967 2480277 Positive_regulation EPHB2 FGF21 21152424 2486381 Positive_regulation EPHB2 FGF21 21364986 2504737 Positive_regulation EPHB2 FGF21 21364986 2504787 Positive_regulation EPHB2 FGF21 21816365 615303 Positive_regulation EPHB2 FGF21 21902831 3160647 Positive_regulation EPHB2 FGF21 22078327 261806 Positive_regulation EPHB2 FGF21 22235335 2585927 Positive_regulation EPHB2 FGF21 22298785 1201041 Positive_regulation EPHB2 FGF21 23209571 2722499 Positive_regulation EPHB2 FGF21 23226437 2724809 Positive_regulation EPHB2 FGF21 23301087 2738184 Positive_regulation EPHB2 FGF21 24550718 2300036 Positive_regulation EPHB2 FGF21 24744103 494690 Positive_regulation EPHB2 FGF21 24744103 494911 Positive_regulation EPHB2 FGF21 24744103 494943 Positive_regulation EPHB2 FGF21 24744103 495010 Positive_regulation EPHB2 FGF21 24744103 495034 Positive_regulation EPHB2 FGF21 24824078 2969158 Positive_regulation EPHB2 FGF21 24848261 2972378 Positive_regulation EPHB2 FGF21 25171101 3004211 Positive_regulation EPHB2 FGF21 25514808 3034825 Positive_regulation EPHB2 FGF21 25526563 1136107 Positive_regulation EPHB2 FGF22 11449001 1273048 Positive_regulation EPHB2 FGF22 11449001 1273049 Positive_regulation EPHB2 FGF22 11449001 1273050 Positive_regulation EPHB2 FGF22 11449001 1273051 Positive_regulation EPHB2 FGF22 11449001 1273098 Positive_regulation EPHB2 FGF22 11449001 1273209 Positive_regulation EPHB2 FGF22 11449001 1273257 Positive_regulation EPHB2 FGF22 11449001 1273258 Positive_regulation EPHB2 FGF22 11449001 1273259 Positive_regulation EPHB2 FGF22 11449001 1273363 Positive_regulation EPHB2 FGF22 11449001 1273386 Positive_regulation EPHB2 FGF22 12952943 1296749 Positive_regulation EPHB2 FGF22 15630138 1534087 Positive_regulation EPHB2 FGF22 17553162 300221 Positive_regulation EPHB2 FGF22 18335055 2387141 Positive_regulation EPHB2 FGF22 19333377 2409569 Positive_regulation EPHB2 FGF22 19888221 433919 Positive_regulation EPHB2 FGF22 20422052 2447893 Positive_regulation EPHB2 FGF22 20652960 3170798 Positive_regulation EPHB2 FGF22 20652960 3170914 Positive_regulation EPHB2 FGF22 21048967 2480278 Positive_regulation EPHB2 FGF22 21152424 2486382 Positive_regulation EPHB2 FGF22 21364986 2504738 Positive_regulation EPHB2 FGF22 21364986 2504788 Positive_regulation EPHB2 FGF22 21816365 615304 Positive_regulation EPHB2 FGF22 21902831 3160648 Positive_regulation EPHB2 FGF22 22078327 261807 Positive_regulation EPHB2 FGF22 22235335 2585928 Positive_regulation EPHB2 FGF22 22298785 1201042 Positive_regulation EPHB2 FGF22 23226437 2724810 Positive_regulation EPHB2 FGF22 24550718 2300037 Positive_regulation EPHB2 FGF22 24744103 494691 Positive_regulation EPHB2 FGF22 24744103 494912 Positive_regulation EPHB2 FGF22 24744103 494944 Positive_regulation EPHB2 FGF22 24744103 495011 Positive_regulation EPHB2 FGF22 24744103 495035 Positive_regulation EPHB2 FGF22 24824078 2969159 Positive_regulation EPHB2 FGF22 25171101 3004212 Positive_regulation EPHB2 FGF22 25514808 3034826 Positive_regulation EPHB2 FGF22 25526563 1136108 Positive_regulation EPHB2 FGF23 11449001 1273052 Positive_regulation EPHB2 FGF23 11449001 1273053 Positive_regulation EPHB2 FGF23 11449001 1273054 Positive_regulation EPHB2 FGF23 11449001 1273055 Positive_regulation EPHB2 FGF23 11449001 1273099 Positive_regulation EPHB2 FGF23 11449001 1273210 Positive_regulation EPHB2 FGF23 11449001 1273260 Positive_regulation EPHB2 FGF23 11449001 1273261 Positive_regulation EPHB2 FGF23 11449001 1273262 Positive_regulation EPHB2 FGF23 11449001 1273364 Positive_regulation EPHB2 FGF23 11449001 1273387 Positive_regulation EPHB2 FGF23 12952943 1296750 Positive_regulation EPHB2 FGF23 15630138 1534088 Positive_regulation EPHB2 FGF23 17553162 300222 Positive_regulation EPHB2 FGF23 18335055 2387142 Positive_regulation EPHB2 FGF23 19333377 2409570 Positive_regulation EPHB2 FGF23 19888221 433920 Positive_regulation EPHB2 FGF23 20422052 2447894 Positive_regulation EPHB2 FGF23 20652960 3170799 Positive_regulation EPHB2 FGF23 20652960 3170915 Positive_regulation EPHB2 FGF23 20730630 616518 Positive_regulation EPHB2 FGF23 21048967 2480279 Positive_regulation EPHB2 FGF23 21152424 2486383 Positive_regulation EPHB2 FGF23 21346724 1709680 Positive_regulation EPHB2 FGF23 21364986 2504739 Positive_regulation EPHB2 FGF23 21364986 2504789 Positive_regulation EPHB2 FGF23 21633782 477926 Positive_regulation EPHB2 FGF23 21633782 477932 Positive_regulation EPHB2 FGF23 21816365 615305 Positive_regulation EPHB2 FGF23 21902831 3160649 Positive_regulation EPHB2 FGF23 22078327 261808 Positive_regulation EPHB2 FGF23 22235335 2585929 Positive_regulation EPHB2 FGF23 22298785 1201043 Positive_regulation EPHB2 FGF23 23226437 2724811 Positive_regulation EPHB2 FGF23 24550718 2300038 Positive_regulation EPHB2 FGF23 24695641 2948300 Positive_regulation EPHB2 FGF23 24744103 494692 Positive_regulation EPHB2 FGF23 24744103 494913 Positive_regulation EPHB2 FGF23 24744103 494945 Positive_regulation EPHB2 FGF23 24744103 495012 Positive_regulation EPHB2 FGF23 24744103 495036 Positive_regulation EPHB2 FGF23 24824078 2969160 Positive_regulation EPHB2 FGF23 25171101 3004213 Positive_regulation EPHB2 FGF23 25514808 3034827 Positive_regulation EPHB2 FGF23 25526563 1136109 Positive_regulation EPHB2 FGF3 11449001 1273056 Positive_regulation EPHB2 FGF3 11449001 1273057 Positive_regulation EPHB2 FGF3 11449001 1273058 Positive_regulation EPHB2 FGF3 11449001 1273059 Positive_regulation EPHB2 FGF3 11449001 1273100 Positive_regulation EPHB2 FGF3 11449001 1273211 Positive_regulation EPHB2 FGF3 11449001 1273263 Positive_regulation EPHB2 FGF3 11449001 1273264 Positive_regulation EPHB2 FGF3 11449001 1273265 Positive_regulation EPHB2 FGF3 11449001 1273365 Positive_regulation EPHB2 FGF3 11449001 1273388 Positive_regulation EPHB2 FGF3 12952943 1296751 Positive_regulation EPHB2 FGF3 15630138 1534089 Positive_regulation EPHB2 FGF3 17553162 300223 Positive_regulation EPHB2 FGF3 18335055 2387143 Positive_regulation EPHB2 FGF3 19333377 2409571 Positive_regulation EPHB2 FGF3 19888221 433921 Positive_regulation EPHB2 FGF3 20422052 2447895 Positive_regulation EPHB2 FGF3 20652960 3170800 Positive_regulation EPHB2 FGF3 20652960 3170916 Positive_regulation EPHB2 FGF3 21048967 2480280 Positive_regulation EPHB2 FGF3 21152424 2486384 Positive_regulation EPHB2 FGF3 21364986 2504740 Positive_regulation EPHB2 FGF3 21364986 2504790 Positive_regulation EPHB2 FGF3 21816365 615306 Positive_regulation EPHB2 FGF3 21902831 3160650 Positive_regulation EPHB2 FGF3 22078327 261809 Positive_regulation EPHB2 FGF3 22235335 2585930 Positive_regulation EPHB2 FGF3 22298785 1201044 Positive_regulation EPHB2 FGF3 23226437 2724812 Positive_regulation EPHB2 FGF3 24550718 2300039 Positive_regulation EPHB2 FGF3 24744103 494693 Positive_regulation EPHB2 FGF3 24744103 494914 Positive_regulation EPHB2 FGF3 24744103 494946 Positive_regulation EPHB2 FGF3 24744103 495013 Positive_regulation EPHB2 FGF3 24744103 495037 Positive_regulation EPHB2 FGF3 24824078 2969161 Positive_regulation EPHB2 FGF3 25171101 3004214 Positive_regulation EPHB2 FGF3 25514808 3034828 Positive_regulation EPHB2 FGF3 25526563 1136110 Positive_regulation EPHB2 FGF4 11449001 1273060 Positive_regulation EPHB2 FGF4 11449001 1273061 Positive_regulation EPHB2 FGF4 11449001 1273062 Positive_regulation EPHB2 FGF4 11449001 1273063 Positive_regulation EPHB2 FGF4 11449001 1273101 Positive_regulation EPHB2 FGF4 11449001 1273212 Positive_regulation EPHB2 FGF4 11449001 1273266 Positive_regulation EPHB2 FGF4 11449001 1273267 Positive_regulation EPHB2 FGF4 11449001 1273268 Positive_regulation EPHB2 FGF4 11449001 1273366 Positive_regulation EPHB2 FGF4 11449001 1273389 Positive_regulation EPHB2 FGF4 12952943 1296752 Positive_regulation EPHB2 FGF4 15630138 1534090 Positive_regulation EPHB2 FGF4 17553162 300224 Positive_regulation EPHB2 FGF4 18335055 2387144 Positive_regulation EPHB2 FGF4 19333377 2409572 Positive_regulation EPHB2 FGF4 19888221 433922 Positive_regulation EPHB2 FGF4 20422052 2447896 Positive_regulation EPHB2 FGF4 20652960 3170801 Positive_regulation EPHB2 FGF4 20652960 3170917 Positive_regulation EPHB2 FGF4 21048967 2480281 Positive_regulation EPHB2 FGF4 21152424 2486385 Positive_regulation EPHB2 FGF4 21364986 2504741 Positive_regulation EPHB2 FGF4 21364986 2504791 Positive_regulation EPHB2 FGF4 21816365 615307 Positive_regulation EPHB2 FGF4 21902831 3160651 Positive_regulation EPHB2 FGF4 22078327 261810 Positive_regulation EPHB2 FGF4 22235335 2585931 Positive_regulation EPHB2 FGF4 22298785 1201045 Positive_regulation EPHB2 FGF4 22298785 1201046 Positive_regulation EPHB2 FGF4 23226437 2724813 Positive_regulation EPHB2 FGF4 23967228 2835113 Positive_regulation EPHB2 FGF4 23967228 2835115 Positive_regulation EPHB2 FGF4 23967228 2835116 Positive_regulation EPHB2 FGF4 24550718 2300040 Positive_regulation EPHB2 FGF4 24643025 2935528 Positive_regulation EPHB2 FGF4 24744103 494694 Positive_regulation EPHB2 FGF4 24744103 494915 Positive_regulation EPHB2 FGF4 24744103 494947 Positive_regulation EPHB2 FGF4 24744103 495014 Positive_regulation EPHB2 FGF4 24744103 495038 Positive_regulation EPHB2 FGF4 24824078 2969162 Positive_regulation EPHB2 FGF4 25171101 3004215 Positive_regulation EPHB2 FGF4 25514808 3034829 Positive_regulation EPHB2 FGF4 25526563 1136111 Positive_regulation EPHB2 FGF5 11449001 1273064 Positive_regulation EPHB2 FGF5 11449001 1273065 Positive_regulation EPHB2 FGF5 11449001 1273066 Positive_regulation EPHB2 FGF5 11449001 1273067 Positive_regulation EPHB2 FGF5 11449001 1273102 Positive_regulation EPHB2 FGF5 11449001 1273213 Positive_regulation EPHB2 FGF5 11449001 1273269 Positive_regulation EPHB2 FGF5 11449001 1273270 Positive_regulation EPHB2 FGF5 11449001 1273271 Positive_regulation EPHB2 FGF5 11449001 1273367 Positive_regulation EPHB2 FGF5 11449001 1273390 Positive_regulation EPHB2 FGF5 12952943 1296753 Positive_regulation EPHB2 FGF5 15630138 1534091 Positive_regulation EPHB2 FGF5 17553162 300225 Positive_regulation EPHB2 FGF5 18335055 2387145 Positive_regulation EPHB2 FGF5 19333377 2409573 Positive_regulation EPHB2 FGF5 19888221 433923 Positive_regulation EPHB2 FGF5 20422052 2447897 Positive_regulation EPHB2 FGF5 20652960 3170802 Positive_regulation EPHB2 FGF5 20652960 3170918 Positive_regulation EPHB2 FGF5 21048967 2480282 Positive_regulation EPHB2 FGF5 21152424 2486386 Positive_regulation EPHB2 FGF5 21364986 2504742 Positive_regulation EPHB2 FGF5 21364986 2504792 Positive_regulation EPHB2 FGF5 21816365 615308 Positive_regulation EPHB2 FGF5 21902831 3160652 Positive_regulation EPHB2 FGF5 22078327 261811 Positive_regulation EPHB2 FGF5 22235335 2585932 Positive_regulation EPHB2 FGF5 22298785 1201047 Positive_regulation EPHB2 FGF5 23226437 2724814 Positive_regulation EPHB2 FGF5 24550718 2300041 Positive_regulation EPHB2 FGF5 24744103 494695 Positive_regulation EPHB2 FGF5 24744103 494916 Positive_regulation EPHB2 FGF5 24744103 494948 Positive_regulation EPHB2 FGF5 24744103 495015 Positive_regulation EPHB2 FGF5 24744103 495039 Positive_regulation EPHB2 FGF5 24824078 2969163 Positive_regulation EPHB2 FGF5 25171101 3004216 Positive_regulation EPHB2 FGF5 25514808 3034830 Positive_regulation EPHB2 FGF5 25526563 1136112 Positive_regulation EPHB2 FGF6 11449001 1273068 Positive_regulation EPHB2 FGF6 11449001 1273069 Positive_regulation EPHB2 FGF6 11449001 1273070 Positive_regulation EPHB2 FGF6 11449001 1273071 Positive_regulation EPHB2 FGF6 11449001 1273103 Positive_regulation EPHB2 FGF6 11449001 1273214 Positive_regulation EPHB2 FGF6 11449001 1273272 Positive_regulation EPHB2 FGF6 11449001 1273273 Positive_regulation EPHB2 FGF6 11449001 1273274 Positive_regulation EPHB2 FGF6 11449001 1273368 Positive_regulation EPHB2 FGF6 11449001 1273391 Positive_regulation EPHB2 FGF6 12952943 1296754 Positive_regulation EPHB2 FGF6 15630138 1534092 Positive_regulation EPHB2 FGF6 17553162 300226 Positive_regulation EPHB2 FGF6 18335055 2387146 Positive_regulation EPHB2 FGF6 19333377 2409574 Positive_regulation EPHB2 FGF6 19888221 433924 Positive_regulation EPHB2 FGF6 20422052 2447898 Positive_regulation EPHB2 FGF6 20652960 3170803 Positive_regulation EPHB2 FGF6 20652960 3170919 Positive_regulation EPHB2 FGF6 21048967 2480283 Positive_regulation EPHB2 FGF6 21152424 2486387 Positive_regulation EPHB2 FGF6 21364986 2504743 Positive_regulation EPHB2 FGF6 21364986 2504793 Positive_regulation EPHB2 FGF6 21816365 615309 Positive_regulation EPHB2 FGF6 21902831 3160653 Positive_regulation EPHB2 FGF6 22078327 261812 Positive_regulation EPHB2 FGF6 22235335 2585933 Positive_regulation EPHB2 FGF6 22298785 1201048 Positive_regulation EPHB2 FGF6 23226437 2724815 Positive_regulation EPHB2 FGF6 24550718 2300042 Positive_regulation EPHB2 FGF6 24744103 494696 Positive_regulation EPHB2 FGF6 24744103 494917 Positive_regulation EPHB2 FGF6 24744103 494949 Positive_regulation EPHB2 FGF6 24744103 495016 Positive_regulation EPHB2 FGF6 24744103 495040 Positive_regulation EPHB2 FGF6 24824078 2969164 Positive_regulation EPHB2 FGF6 25171101 3004217 Positive_regulation EPHB2 FGF6 25514808 3034831 Positive_regulation EPHB2 FGF6 25526563 1136113 Positive_regulation EPHB2 FGF7 11449001 1273072 Positive_regulation EPHB2 FGF7 11449001 1273073 Positive_regulation EPHB2 FGF7 11449001 1273074 Positive_regulation EPHB2 FGF7 11449001 1273075 Positive_regulation EPHB2 FGF7 11449001 1273104 Positive_regulation EPHB2 FGF7 11449001 1273215 Positive_regulation EPHB2 FGF7 11449001 1273275 Positive_regulation EPHB2 FGF7 11449001 1273276 Positive_regulation EPHB2 FGF7 11449001 1273277 Positive_regulation EPHB2 FGF7 11449001 1273369 Positive_regulation EPHB2 FGF7 11449001 1273392 Positive_regulation EPHB2 FGF7 12952943 1296755 Positive_regulation EPHB2 FGF7 15630138 1534093 Positive_regulation EPHB2 FGF7 15972105 298226 Positive_regulation EPHB2 FGF7 17553162 300227 Positive_regulation EPHB2 FGF7 18335055 2387147 Positive_regulation EPHB2 FGF7 19333377 2409575 Positive_regulation EPHB2 FGF7 19888221 433925 Positive_regulation EPHB2 FGF7 20422052 2447899 Positive_regulation EPHB2 FGF7 20652960 3170804 Positive_regulation EPHB2 FGF7 20652960 3170920 Positive_regulation EPHB2 FGF7 21048967 2480284 Positive_regulation EPHB2 FGF7 21152424 2486330 Positive_regulation EPHB2 FGF7 21152424 2486388 Positive_regulation EPHB2 FGF7 21224849 769118 Positive_regulation EPHB2 FGF7 21364986 2504744 Positive_regulation EPHB2 FGF7 21364986 2504794 Positive_regulation EPHB2 FGF7 21816365 615310 Positive_regulation EPHB2 FGF7 21902831 3160654 Positive_regulation EPHB2 FGF7 22078327 261813 Positive_regulation EPHB2 FGF7 22235335 2585934 Positive_regulation EPHB2 FGF7 22298785 1201049 Positive_regulation EPHB2 FGF7 23226437 2724816 Positive_regulation EPHB2 FGF7 24124521 2865989 Positive_regulation EPHB2 FGF7 24550718 2300043 Positive_regulation EPHB2 FGF7 24744103 494697 Positive_regulation EPHB2 FGF7 24744103 494918 Positive_regulation EPHB2 FGF7 24744103 494950 Positive_regulation EPHB2 FGF7 24744103 495017 Positive_regulation EPHB2 FGF7 24744103 495041 Positive_regulation EPHB2 FGF7 24824078 2969165 Positive_regulation EPHB2 FGF7 25171101 3004218 Positive_regulation EPHB2 FGF7 25514808 3034832 Positive_regulation EPHB2 FGF7 25526563 1136114 Positive_regulation EPHB2 FGF8 11449001 1273076 Positive_regulation EPHB2 FGF8 11449001 1273077 Positive_regulation EPHB2 FGF8 11449001 1273078 Positive_regulation EPHB2 FGF8 11449001 1273079 Positive_regulation EPHB2 FGF8 11449001 1273105 Positive_regulation EPHB2 FGF8 11449001 1273216 Positive_regulation EPHB2 FGF8 11449001 1273278 Positive_regulation EPHB2 FGF8 11449001 1273279 Positive_regulation EPHB2 FGF8 11449001 1273280 Positive_regulation EPHB2 FGF8 11449001 1273370 Positive_regulation EPHB2 FGF8 11449001 1273393 Positive_regulation EPHB2 FGF8 12952943 1296756 Positive_regulation EPHB2 FGF8 15630138 1534094 Positive_regulation EPHB2 FGF8 17553162 300228 Positive_regulation EPHB2 FGF8 18335055 2387148 Positive_regulation EPHB2 FGF8 19333377 2409576 Positive_regulation EPHB2 FGF8 19888221 433926 Positive_regulation EPHB2 FGF8 20422052 2447900 Positive_regulation EPHB2 FGF8 20652960 3170805 Positive_regulation EPHB2 FGF8 20652960 3170921 Positive_regulation EPHB2 FGF8 21048967 2480285 Positive_regulation EPHB2 FGF8 21152424 2486389 Positive_regulation EPHB2 FGF8 21364986 2504745 Positive_regulation EPHB2 FGF8 21364986 2504795 Positive_regulation EPHB2 FGF8 21816365 615311 Positive_regulation EPHB2 FGF8 21902831 3160655 Positive_regulation EPHB2 FGF8 22078327 261814 Positive_regulation EPHB2 FGF8 22235335 2585935 Positive_regulation EPHB2 FGF8 22298785 1201050 Positive_regulation EPHB2 FGF8 23213390 168179 Positive_regulation EPHB2 FGF8 23226437 2724817 Positive_regulation EPHB2 FGF8 24550718 2300044 Positive_regulation EPHB2 FGF8 24744103 494698 Positive_regulation EPHB2 FGF8 24744103 494919 Positive_regulation EPHB2 FGF8 24744103 494951 Positive_regulation EPHB2 FGF8 24744103 495018 Positive_regulation EPHB2 FGF8 24744103 495042 Positive_regulation EPHB2 FGF8 24824078 2969166 Positive_regulation EPHB2 FGF8 25171101 3004219 Positive_regulation EPHB2 FGF8 25514808 3034833 Positive_regulation EPHB2 FGF8 25526563 1136115 Positive_regulation EPHB2 FGF9 11449001 1273080 Positive_regulation EPHB2 FGF9 11449001 1273081 Positive_regulation EPHB2 FGF9 11449001 1273082 Positive_regulation EPHB2 FGF9 11449001 1273083 Positive_regulation EPHB2 FGF9 11449001 1273106 Positive_regulation EPHB2 FGF9 11449001 1273217 Positive_regulation EPHB2 FGF9 11449001 1273281 Positive_regulation EPHB2 FGF9 11449001 1273282 Positive_regulation EPHB2 FGF9 11449001 1273283 Positive_regulation EPHB2 FGF9 11449001 1273371 Positive_regulation EPHB2 FGF9 11449001 1273394 Positive_regulation EPHB2 FGF9 12952943 1296757 Positive_regulation EPHB2 FGF9 15630138 1534095 Positive_regulation EPHB2 FGF9 17553162 300229 Positive_regulation EPHB2 FGF9 18335055 2387149 Positive_regulation EPHB2 FGF9 19333377 2409577 Positive_regulation EPHB2 FGF9 19888221 433927 Positive_regulation EPHB2 FGF9 20422052 2447901 Positive_regulation EPHB2 FGF9 20652960 3170806 Positive_regulation EPHB2 FGF9 20652960 3170922 Positive_regulation EPHB2 FGF9 21048967 2480286 Positive_regulation EPHB2 FGF9 21152424 2486390 Positive_regulation EPHB2 FGF9 21364986 2504746 Positive_regulation EPHB2 FGF9 21364986 2504796 Positive_regulation EPHB2 FGF9 21816365 615312 Positive_regulation EPHB2 FGF9 21902831 3160656 Positive_regulation EPHB2 FGF9 22078327 261815 Positive_regulation EPHB2 FGF9 22235335 2585936 Positive_regulation EPHB2 FGF9 22298785 1201051 Positive_regulation EPHB2 FGF9 23226437 2724818 Positive_regulation EPHB2 FGF9 24550718 2300045 Positive_regulation EPHB2 FGF9 24744103 494699 Positive_regulation EPHB2 FGF9 24744103 494920 Positive_regulation EPHB2 FGF9 24744103 494952 Positive_regulation EPHB2 FGF9 24744103 495019 Positive_regulation EPHB2 FGF9 24744103 495043 Positive_regulation EPHB2 FGF9 24824078 2969167 Positive_regulation EPHB2 FGF9 25171101 3004220 Positive_regulation EPHB2 FGF9 25514808 3034834 Positive_regulation EPHB2 FGF9 25526563 1136116 Positive_regulation EPHB2 FGFR1 19047466 1361940 Positive_regulation EPHB2 FGFR1 19047466 1361941 Positive_regulation EPHB2 FGFR1 20459789 303956 Positive_regulation EPHB2 FGFR1 21152424 2486341 Positive_regulation EPHB2 FGFR1 21720547 2531616 Positive_regulation EPHB2 FGFR1 22348054 2596640 Positive_regulation EPHB2 FGFR1 22761819 2658580 Positive_regulation EPHB2 FGFR1 23308088 2738406 Positive_regulation EPHB2 FGFR1 23388178 521827 Positive_regulation EPHB2 FGFR1 23583981 1951374 Positive_regulation EPHB2 FGFR1 24752320 2956521 Positive_regulation EPHB2 FGFR1 24848261 2972380 Positive_regulation EPHB2 FGFR1 24980830 2194857 Positive_regulation EPHB2 FGFR1 9400937 446702 Positive_regulation EPHB2 FGFR2 15972105 298227 Positive_regulation EPHB2 FGFR2 19047466 1361942 Positive_regulation EPHB2 FGFR2 20459789 303957 Positive_regulation EPHB2 FGFR2 21152424 2486342 Positive_regulation EPHB2 FGFR2 22247000 777633 Positive_regulation EPHB2 FGFR2 22247000 777686 Positive_regulation EPHB2 FGFR2 22348054 2596641 Positive_regulation EPHB2 FGFR2 22761819 2658581 Positive_regulation EPHB2 FGFR2 23308088 2738407 Positive_regulation EPHB2 FGFR2 24752320 2956522 Positive_regulation EPHB2 FGFR2 24968263 2984100 Positive_regulation EPHB2 FGFR3 19047466 1361943 Positive_regulation EPHB2 FGFR3 19088846 2402486 Positive_regulation EPHB2 FGFR3 19088846 2402487 Positive_regulation EPHB2 FGFR3 19088846 2402493 Positive_regulation EPHB2 FGFR3 19088846 2402498 Positive_regulation EPHB2 FGFR3 19088846 2402509 Positive_regulation EPHB2 FGFR3 20459789 303958 Positive_regulation EPHB2 FGFR3 21152424 2486343 Positive_regulation EPHB2 FGFR3 22348054 2596642 Positive_regulation EPHB2 FGFR3 22761819 2658582 Positive_regulation EPHB2 FGFR3 23308088 2738408 Positive_regulation EPHB2 FGFR3 23971049 183248 Positive_regulation EPHB2 FGFR3 24752320 2956523 Positive_regulation EPHB2 FGFR4 19047466 1361944 Positive_regulation EPHB2 FGFR4 20459789 303959 Positive_regulation EPHB2 FGFR4 21152424 2486344 Positive_regulation EPHB2 FGFR4 22348054 2596643 Positive_regulation EPHB2 FGFR4 22761819 2658583 Positive_regulation EPHB2 FGFR4 23308088 2738409 Positive_regulation EPHB2 FGFR4 24752320 2956524 Positive_regulation EPHB2 FHOD1 20550706 402691 Positive_regulation EPHB2 FIGF 22545097 2623336 Positive_regulation EPHB2 FIP1L1 24359404 538659 Positive_regulation EPHB2 FLT1 18931684 1960492 Positive_regulation EPHB2 FLT3 20698720 745670 Positive_regulation EPHB2 FLT3 21048955 2480105 Positive_regulation EPHB2 FLT3 21048955 2480133 Positive_regulation EPHB2 FLT3 23300935 2737538 Positive_regulation EPHB2 FLT3 23936658 1719161 Positive_regulation EPHB2 FLT3LG 21422499 2175735 Positive_regulation EPHB2 FLT4 22745786 2656454 Positive_regulation EPHB2 FN1 10385525 1247195 Positive_regulation EPHB2 FN1 10491389 1249386 Positive_regulation EPHB2 FN1 10491389 1249413 Positive_regulation EPHB2 FN1 19930650 526216 Positive_regulation EPHB2 FN1 19930650 526296 Positive_regulation EPHB2 FN1 21547158 3177184 Positive_regulation EPHB2 FN1 22349827 2146396 Positive_regulation EPHB2 FN1 22528856 161523 Positive_regulation EPHB2 FN1 23886475 687005 Positive_regulation EPHB2 FN1 24752318 2956501 Positive_regulation EPHB2 FOS 14735164 424165 Positive_regulation EPHB2 FOS 19956756 2432692 Positive_regulation EPHB2 FOS 20652960 3170895 Positive_regulation EPHB2 FOS 22399974 3158764 Positive_regulation EPHB2 FOS 22427889 2610576 Positive_regulation EPHB2 FOS 23524590 218365 Positive_regulation EPHB2 FOS 24743235 2954901 Positive_regulation EPHB2 FOS 25530786 827549 Positive_regulation EPHB2 FOXC2 23815774 380262 Positive_regulation EPHB2 FOXC2 23815774 380263 Positive_regulation EPHB2 FOXM1 21858223 2546973 Positive_regulation EPHB2 FOXM1 21858223 2546982 Positive_regulation EPHB2 FOXO1 20375467 26925 Positive_regulation EPHB2 FOXO1 21980390 2560209 Positive_regulation EPHB2 FOXO1 22649777 939908 Positive_regulation EPHB2 FOXO3 20375467 26926 Positive_regulation EPHB2 FOXO3 20858281 1859196 Positive_regulation EPHB2 FOXO3 21980390 2560210 Positive_regulation EPHB2 FOXO3 22649777 939909 Positive_regulation EPHB2 FOXO4 20375467 26927 Positive_regulation EPHB2 FOXO4 22649777 939910 Positive_regulation EPHB2 FOXO6 20375467 26924 Positive_regulation EPHB2 FOXO6 22649777 939907 Positive_regulation EPHB2 FPR1 24192910 1920118 Positive_regulation EPHB2 FPR1 24192910 1920122 Positive_regulation EPHB2 FPR2 23549262 1104647 Positive_regulation EPHB2 FRS2 16009726 1321423 Positive_regulation EPHB2 FRS2 18335055 2387126 Positive_regulation EPHB2 FRS2 20652960 3170650 Positive_regulation EPHB2 FRS2 20652960 3170900 Positive_regulation EPHB2 FRS2 22078327 261771 Positive_regulation EPHB2 FRS2 22078327 262682 Positive_regulation EPHB2 FRS2 22235335 2585961 Positive_regulation EPHB2 FRS3 22078327 261770 Positive_regulation EPHB2 FSHR 16787538 3096301 Positive_regulation EPHB2 FST 24568636 1031457 Positive_regulation EPHB2 FUT1 24495360 1627721 Positive_regulation EPHB2 FXYD1 23984088 1150957 Positive_regulation EPHB2 FXYD6 24715268 3081988 Positive_regulation EPHB2 FYN 22566861 899005 Positive_regulation EPHB2 FYN 22566861 899009 Positive_regulation EPHB2 FYN 22880054 2673953 Positive_regulation EPHB2 GAB1 12177047 1286338 Positive_regulation EPHB2 GAB1 17158954 1335294 Positive_regulation EPHB2 GAB1 17211494 1083628 Positive_regulation EPHB2 GAB1 19357636 1902995 Positive_regulation EPHB2 GAB1 21408212 2292257 Positive_regulation EPHB2 GAB2 19737390 526045 Positive_regulation EPHB2 GAB2 21552417 1057113 Positive_regulation EPHB2 GAB2 21552417 1057128 Positive_regulation EPHB2 GABBR1 21448293 2510023 Positive_regulation EPHB2 GABBR1 23908646 878991 Positive_regulation EPHB2 GABBR2 21448293 2510024 Positive_regulation EPHB2 GABBR2 23908646 878992 Positive_regulation EPHB2 GABPA 20482831 1656234 Positive_regulation EPHB2 GABPA 23637839 2786221 Positive_regulation EPHB2 GABPA 24024177 3093505 Positive_regulation EPHB2 GAP43 21853090 2543207 Positive_regulation EPHB2 GAS6 25337673 2205657 Positive_regulation EPHB2 GATA1 20824065 2473570 Positive_regulation EPHB2 GDF15 21798071 508584 Positive_regulation EPHB2 GDF15 22936174 1239113 Positive_regulation EPHB2 GDF15 24597762 152524 Positive_regulation EPHB2 GDF2 24670474 1125619 Positive_regulation EPHB2 GDF2 24670474 1125643 Positive_regulation EPHB2 GDNF 12370242 1286692 Positive_regulation EPHB2 GDNF 12370242 1286695 Positive_regulation EPHB2 GDNF 12370242 1286716 Positive_regulation EPHB2 GDNF 12370242 1286717 Positive_regulation EPHB2 GDNF 15769183 2257992 Positive_regulation EPHB2 GDNF 19649251 2422257 Positive_regulation EPHB2 GDNF 19649251 2422258 Positive_regulation EPHB2 GDNF 19649251 2422266 Positive_regulation EPHB2 GDNF 19649251 2422267 Positive_regulation EPHB2 GDNF 20422010 2447330 Positive_regulation EPHB2 GDNF 21450093 1898038 Positive_regulation EPHB2 GDNF 23468876 2759903 Positive_regulation EPHB2 GDNF 24603431 2357223 Positive_regulation EPHB2 GEMIN2 22348054 2596633 Positive_regulation EPHB2 GEMIN4 22348054 2596635 Positive_regulation EPHB2 GEMIN5 22348054 2596636 Positive_regulation EPHB2 GEMIN6 22348054 2596637 Positive_regulation EPHB2 GEMIN7 22348054 2596638 Positive_regulation EPHB2 GHITM 21909400 2551988 Positive_regulation EPHB2 GHITM 21909400 2551989 Positive_regulation EPHB2 GHITM 21909400 2552019 Positive_regulation EPHB2 GHITM 21909400 2552020 Positive_regulation EPHB2 GHITM 21909400 2552021 Positive_regulation EPHB2 GHITM 21909400 2552022 Positive_regulation EPHB2 GHR 22649371 874990 Positive_regulation EPHB2 GHR 23761784 878682 Positive_regulation EPHB2 GHSR 19262695 2406772 Positive_regulation EPHB2 GHSR 22514603 2619445 Positive_regulation EPHB2 GNAT1 20162012 1089707 Positive_regulation EPHB2 GNAT2 20162012 1089708 Positive_regulation EPHB2 GNAT3 20162012 1089706 Positive_regulation EPHB2 GNRH1 20585619 2291370 Positive_regulation EPHB2 GNRH1 20688134 1880917 Positive_regulation EPHB2 GNRH1 22235371 1686991 Positive_regulation EPHB2 GNRH1 22235371 1687008 Positive_regulation EPHB2 GNRH1 22235371 1687024 Positive_regulation EPHB2 GNRH1 22808094 2664304 Positive_regulation EPHB2 GNRH1 22808094 2664329 Positive_regulation EPHB2 GNRH1 23596387 938065 Positive_regulation EPHB2 GNRH1 24312080 879545 Positive_regulation EPHB2 GNRH1 24478760 879911 Positive_regulation EPHB2 GNRH1 25148070 2003488 Positive_regulation EPHB2 GNRH1 PMC2377328 2003635 Positive_regulation EPHB2 GNRH1 PMC2377328 2003663 Positive_regulation EPHB2 GNRHR 20688134 1880908 Positive_regulation EPHB2 GNRHR 22808094 2664328 Positive_regulation EPHB2 GNRHR 24482225 1208925 Positive_regulation EPHB2 GNRHR 24482225 1208926 Positive_regulation EPHB2 GNRHR 24482225 1208927 Positive_regulation EPHB2 GP1BA 23997795 822756 Positive_regulation EPHB2 GP1BB 23997795 822757 Positive_regulation EPHB2 GPC3 18413366 505639 Positive_regulation EPHB2 GPC4 24633815 3081945 Positive_regulation EPHB2 GPER1 21617769 3129715 Positive_regulation EPHB2 GPER1 22251451 469689 Positive_regulation EPHB2 GPER1 23458715 795144 Positive_regulation EPHB2 GPER1 24379833 2120008 Positive_regulation EPHB2 GPER1 24379833 2120021 Positive_regulation EPHB2 GPER1 24481325 787954 Positive_regulation EPHB2 GPR35 22511974 2619162 Positive_regulation EPHB2 GPR37 24244600 2880558 Positive_regulation EPHB2 GPR37L1 24244600 2880557 Positive_regulation EPHB2 GPR55 23869178 490882 Positive_regulation EPHB2 GPR55 23869178 490890 Positive_regulation EPHB2 GRAP2 17205106 1054719 Positive_regulation EPHB2 GRAP2 24058556 2847997 Positive_regulation EPHB2 GRAP2 24722483 2951439 Positive_regulation EPHB2 GRB2 18335055 2387150 Positive_regulation EPHB2 GRB2 18404483 3087906 Positive_regulation EPHB2 GRB2 20652960 3170732 Positive_regulation EPHB2 GRB2 20652960 3170923 Positive_regulation EPHB2 GRB2 20652960 3170928 Positive_regulation EPHB2 GRB2 21408212 2292258 Positive_regulation EPHB2 GRB2 24142503 2185072 Positive_regulation EPHB2 GRB2 24709879 617255 Positive_regulation EPHB2 GRB2 9763608 1604080 Positive_regulation EPHB2 GRB7 23285101 2732529 Positive_regulation EPHB2 GRB7 23285101 2732541 Positive_regulation EPHB2 GRB7 23285101 2732543 Positive_regulation EPHB2 GRIN2B 23341972 2741510 Positive_regulation EPHB2 GRIN2B 24391850 2904749 Positive_regulation EPHB2 GRIN2B 24391850 2904753 Positive_regulation EPHB2 GRIN2B 25070539 1901340 Positive_regulation EPHB2 GRIN2B 25100942 932200 Positive_regulation EPHB2 GRK1 23977191 2838879 Positive_regulation EPHB2 GRK4 23977191 2838881 Positive_regulation EPHB2 GRK5 23977191 2838882 Positive_regulation EPHB2 GRK6 23497290 1867545 Positive_regulation EPHB2 GRK6 23977191 2838883 Positive_regulation EPHB2 GRK7 23977191 2838880 Positive_regulation EPHB2 GRM1 23085756 2148928 Positive_regulation EPHB2 GRM1 23125836 952320 Positive_regulation EPHB2 GRM1 23433248 1899492 Positive_regulation EPHB2 GRM5 22267161 1967367 Positive_regulation EPHB2 GRM5 23125836 952323 Positive_regulation EPHB2 GRM5 23125836 952332 Positive_regulation EPHB2 GRM5 23181395 1665158 Positive_regulation EPHB2 GRM5 23433248 1899493 Positive_regulation EPHB2 GRM5 24653683 921986 Positive_regulation EPHB2 GRM7 21255632 2012084 Positive_regulation EPHB2 GRP 23211542 2181822 Positive_regulation EPHB2 GSTM1 22867088 2233277 Positive_regulation EPHB2 GSTM1 22867088 2233297 Positive_regulation EPHB2 GSTM1 22867088 2233305 Positive_regulation EPHB2 GYS1 24841081 2971496 Positive_regulation EPHB2 GYS2 24841081 2971497 Positive_regulation EPHB2 HAS1 23884081 1703461 Positive_regulation EPHB2 HAS1 23884081 1703463 Positive_regulation EPHB2 HAVCR1 20566714 1558511 Positive_regulation EPHB2 HBEGF 21386996 2506135 Positive_regulation EPHB2 HBEGF 22873932 532999 Positive_regulation EPHB2 HBEGF 22873932 533017 Positive_regulation EPHB2 HBEGF 22873932 533038 Positive_regulation EPHB2 HBEGF 23028692 2692517 Positive_regulation EPHB2 HBEGF 24136232 568205 Positive_regulation EPHB2 HBEGF 24136232 568206 Positive_regulation EPHB2 HBEGF PMC3760629 1606197 Positive_regulation EPHB2 HCRT 24391536 938521 Positive_regulation EPHB2 HCRTR1 24391536 938523 Positive_regulation EPHB2 HDAC1 16262446 2258785 Positive_regulation EPHB2 HDAC1 23166712 2718720 Positive_regulation EPHB2 HDAC2 16262446 2258786 Positive_regulation EPHB2 HDAC2 23166712 2718721 Positive_regulation EPHB2 HES1 18950493 524938 Positive_regulation EPHB2 HFE2 21625488 2524462 Positive_regulation EPHB2 HGF 15972796 2016757 Positive_regulation EPHB2 HGF 16646560 1711380 Positive_regulation EPHB2 HGF 17158954 1335323 Positive_regulation EPHB2 HGF 18218921 849397 Positive_regulation EPHB2 HGF 18795097 2396570 Positive_regulation EPHB2 HGF 19497102 1503741 Positive_regulation EPHB2 HGF 20926686 1783323 Positive_regulation EPHB2 HGF 20977782 3168132 Positive_regulation EPHB2 HGF 21496277 259555 Positive_regulation EPHB2 HGF 21680714 1791522 Positive_regulation EPHB2 HGF 21680714 1791528 Positive_regulation EPHB2 HGF 21680714 1791532 Positive_regulation EPHB2 HGF 21680714 1791533 Positive_regulation EPHB2 HGF 21680714 1791534 Positive_regulation EPHB2 HGF 21680714 1791535 Positive_regulation EPHB2 HGF 21680714 1791539 Positive_regulation EPHB2 HGF 21680714 1791540 Positive_regulation EPHB2 HGF 21680714 1791543 Positive_regulation EPHB2 HGF 21680714 1791544 Positive_regulation EPHB2 HGF 21680714 1791547 Positive_regulation EPHB2 HGF 21680714 1791548 Positive_regulation EPHB2 HGF 21680714 1791550 Positive_regulation EPHB2 HGF 21902831 3160710 Positive_regulation EPHB2 HGF 22629409 2645690 Positive_regulation EPHB2 HGF 22763439 1988824 Positive_regulation EPHB2 HGF 23028692 2692511 Positive_regulation EPHB2 HGF 23028692 2692514 Positive_regulation EPHB2 HGF 23028692 2692516 Positive_regulation EPHB2 HGF 23341789 496350 Positive_regulation EPHB2 HGF 23341789 496369 Positive_regulation EPHB2 HGF 23493885 176248 Positive_regulation EPHB2 HGF 23626807 2784825 Positive_regulation EPHB2 HGF 23626807 2784857 Positive_regulation EPHB2 HGF 23667593 2790719 Positive_regulation EPHB2 HGF 23878598 821642 Positive_regulation EPHB2 HGF 23878598 821646 Positive_regulation EPHB2 HGF 23878598 821648 Positive_regulation EPHB2 HGF 23878598 821649 Positive_regulation EPHB2 HGF 24223799 2877070 Positive_regulation EPHB2 HGF 24223799 2877074 Positive_regulation EPHB2 HGF 24287743 502467 Positive_regulation EPHB2 HGF 24287743 502493 Positive_regulation EPHB2 HGF 24517345 3163318 Positive_regulation EPHB2 HGF 24744103 494523 Positive_regulation EPHB2 HGF 24744103 494770 Positive_regulation EPHB2 HGF 24814316 701140 Positive_regulation EPHB2 HGF 24927123 2979906 Positive_regulation EPHB2 HGF 25534569 505415 Positive_regulation EPHB2 HGF 25574187 845464 Positive_regulation EPHB2 HGF 25593982 2172143 Positive_regulation EPHB2 HGF 25593982 2172180 Positive_regulation EPHB2 HGF 25593982 2172181 Positive_regulation EPHB2 HIST1H4E 21989417 1041868 Positive_regulation EPHB2 HIST2H3A 18053252 3212131 Positive_regulation EPHB2 HIST2H3A 18053252 3212132 Positive_regulation EPHB2 HIST3H3 21989417 1041867 Positive_regulation EPHB2 HK1 21085672 2483159 Positive_regulation EPHB2 HK1 21085672 2483192 Positive_regulation EPHB2 HK2 21085672 2483160 Positive_regulation EPHB2 HK2 21085672 2483193 Positive_regulation EPHB2 HK3 21085672 2483161 Positive_regulation EPHB2 HK3 21085672 2483194 Positive_regulation EPHB2 HMGB1 11257120 1267953 Positive_regulation EPHB2 HMGB1 17923528 1345114 Positive_regulation EPHB2 HMGB1 23392177 559847 Positive_regulation EPHB2 HMGB1 24603876 2932593 Positive_regulation EPHB2 HMGB1 24710477 618472 Positive_regulation EPHB2 HMGB1 25210949 1484872 Positive_regulation EPHB2 HMOX1 24999379 2229508 Positive_regulation EPHB2 HNF1B 25079440 1128765 Positive_regulation EPHB2 HNRNPF 18282094 3040943 Positive_regulation EPHB2 HNRNPF 24317039 1959483 Positive_regulation EPHB2 HNRNPF 24317039 1959484 Positive_regulation EPHB2 HNRNPF 24317039 1959485 Positive_regulation EPHB2 HNRNPF 24317039 1959514 Positive_regulation EPHB2 HNRNPH1 18282094 3040944 Positive_regulation EPHB2 HNRNPH1 24317039 1959486 Positive_regulation EPHB2 HNRNPH1 24317039 1959487 Positive_regulation EPHB2 HNRNPH1 24317039 1959488 Positive_regulation EPHB2 HNRNPH1 24317039 1959515 Positive_regulation EPHB2 HOMER1 22267161 1967364 Positive_regulation EPHB2 HOMER2 22267161 1967365 Positive_regulation EPHB2 HOMER3 22267161 1967366 Positive_regulation EPHB2 HOOK1 25331952 1211142 Positive_regulation EPHB2 HPSE 19305494 2408462 Positive_regulation EPHB2 HPSE 22773906 1914628 Positive_regulation EPHB2 HPSE 22773906 1914640 Positive_regulation EPHB2 HPSE 24551591 947307 Positive_regulation EPHB2 HRAS 12516548 2001295 Positive_regulation EPHB2 HRAS 12799645 422699 Positive_regulation EPHB2 HRAS 15969750 1844731 Positive_regulation EPHB2 HRAS 17319972 1645346 Positive_regulation EPHB2 HRAS 17449939 1634806 Positive_regulation EPHB2 HRAS 17449939 1634807 Positive_regulation EPHB2 HRAS 17498287 999291 Positive_regulation EPHB2 HRAS 17498287 999294 Positive_regulation EPHB2 HRAS 18030338 2381001 Positive_regulation EPHB2 HRAS 18335053 2386983 Positive_regulation EPHB2 HRAS 18404483 3088019 Positive_regulation EPHB2 HRAS 18404483 3088050 Positive_regulation EPHB2 HRAS 18463697 2289741 Positive_regulation EPHB2 HRAS 18925939 2000817 Positive_regulation EPHB2 HRAS 18949068 2207994 Positive_regulation EPHB2 HRAS 19015320 1361479 Positive_regulation EPHB2 HRAS 19025606 1646455 Positive_regulation EPHB2 HRAS 19025606 1646458 Positive_regulation EPHB2 HRAS 19063885 850714 Positive_regulation EPHB2 HRAS 19137382 621158 Positive_regulation EPHB2 HRAS 19137382 621168 Positive_regulation EPHB2 HRAS 19238206 2406124 Positive_regulation EPHB2 HRAS 19319189 2408574 Positive_regulation EPHB2 HRAS 19492026 3400 Positive_regulation EPHB2 HRAS 19682393 1646601 Positive_regulation EPHB2 HRAS 19707311 175376 Positive_regulation EPHB2 HRAS 19804630 401927 Positive_regulation EPHB2 HRAS 19804630 401950 Positive_regulation EPHB2 HRAS 19804630 401976 Positive_regulation EPHB2 HRAS 19804630 402001 Positive_regulation EPHB2 HRAS 19861649 505909 Positive_regulation EPHB2 HRAS 19878585 254550 Positive_regulation EPHB2 HRAS 20003375 254811 Positive_regulation EPHB2 HRAS 20071468 1772936 Positive_regulation EPHB2 HRAS 20071468 1772937 Positive_regulation EPHB2 HRAS 20071468 1772994 Positive_regulation EPHB2 HRAS 20071468 1773007 Positive_regulation EPHB2 HRAS 20141835 516319 Positive_regulation EPHB2 HRAS 20162012 1089709 Positive_regulation EPHB2 HRAS 20179705 1984092 Positive_regulation EPHB2 HRAS 20549726 701640 Positive_regulation EPHB2 HRAS 20562914 2132756 Positive_regulation EPHB2 HRAS 20562914 2132757 Positive_regulation EPHB2 HRAS 20628654 2455329 Positive_regulation EPHB2 HRAS 20663127 386300 Positive_regulation EPHB2 HRAS 20802521 2135572 Positive_regulation EPHB2 HRAS 21042537 2479649 Positive_regulation EPHB2 HRAS 21479172 2510913 Positive_regulation EPHB2 HRAS 21512581 2234286 Positive_regulation EPHB2 HRAS 21526160 2513802 Positive_regulation EPHB2 HRAS 21541658 616600 Positive_regulation EPHB2 HRAS 21731751 2532424 Positive_regulation EPHB2 HRAS 21731751 2532428 Positive_regulation EPHB2 HRAS 21731751 2532429 Positive_regulation EPHB2 HRAS 21731751 2532433 Positive_regulation EPHB2 HRAS 21756365 405129 Positive_regulation EPHB2 HRAS 21756365 405136 Positive_regulation EPHB2 HRAS 21831290 1505404 Positive_regulation EPHB2 HRAS 21980390 2560143 Positive_regulation EPHB2 HRAS 21994767 3220309 Positive_regulation EPHB2 HRAS 22105357 2144464 Positive_regulation EPHB2 HRAS 22319531 1067179 Positive_regulation EPHB2 HRAS 22363839 1687320 Positive_regulation EPHB2 HRAS 22384111 2605915 Positive_regulation EPHB2 HRAS 22384148 2607026 Positive_regulation EPHB2 HRAS 22419879 2120942 Positive_regulation EPHB2 HRAS 22523682 1687953 Positive_regulation EPHB2 HRAS 22920937 406782 Positive_regulation EPHB2 HRAS 22971289 472098 Positive_regulation EPHB2 HRAS 23412389 559973 Positive_regulation EPHB2 HRAS 23425254 3215210 Positive_regulation EPHB2 HRAS 23533771 1497058 Positive_regulation EPHB2 HRAS 23587357 734347 Positive_regulation EPHB2 HRAS 23626807 2784858 Positive_regulation EPHB2 HRAS 23690850 818986 Positive_regulation EPHB2 HRAS 23707528 614142 Positive_regulation EPHB2 HRAS 23738079 3081135 Positive_regulation EPHB2 HRAS 23741352 2800461 Positive_regulation EPHB2 HRAS 23758320 151518 Positive_regulation EPHB2 HRAS 23802073 2162519 Positive_regulation EPHB2 HRAS 23825558 2809657 Positive_regulation EPHB2 HRAS 23902637 536944 Positive_regulation EPHB2 HRAS 24220297 1920138 Positive_regulation EPHB2 HRAS 24231770 545244 Positive_regulation EPHB2 HRAS 24265712 2884984 Positive_regulation EPHB2 HRAS 24309939 570092 Positive_regulation EPHB2 HRAS 24330074 1482214 Positive_regulation EPHB2 HRAS 24396730 668236 Positive_regulation EPHB2 HRAS 24684778 1873582 Positive_regulation EPHB2 HRAS 24722482 840656 Positive_regulation EPHB2 HRAS 24994118 2194890 Positive_regulation EPHB2 HRAS 25099740 1651935 Positive_regulation EPHB2 HRAS 25275324 3012019 Positive_regulation EPHB2 HRAS 25397617 3027236 Positive_regulation EPHB2 HRAS 9432981 1602477 Positive_regulation EPHB2 HRAS PMC2173290 1474953 Positive_regulation EPHB2 HRG 18004277 1902376 Positive_regulation EPHB2 HRG 18004277 1902377 Positive_regulation EPHB2 HRG 18004277 1902378 Positive_regulation EPHB2 HRG 18004277 1902379 Positive_regulation EPHB2 HRG 18004277 1902398 Positive_regulation EPHB2 HRG 18004277 1902399 Positive_regulation EPHB2 HRG 18004277 1902400 Positive_regulation EPHB2 HRG 18004277 1902401 Positive_regulation EPHB2 HRG 18004277 1902402 Positive_regulation EPHB2 HRG 18004277 1902451 Positive_regulation EPHB2 HRG 18004277 1902452 Positive_regulation EPHB2 HRG 18004277 1902482 Positive_regulation EPHB2 HRG 18004277 1902488 Positive_regulation EPHB2 HRG 18004277 1902494 Positive_regulation EPHB2 HRG 18004277 1902511 Positive_regulation EPHB2 HRG 19552798 362289 Positive_regulation EPHB2 HRG 19878579 283575 Positive_regulation EPHB2 HRG 19878579 283576 Positive_regulation EPHB2 HRG 22627808 834549 Positive_regulation EPHB2 HRG 22627808 834559 Positive_regulation EPHB2 HRG 22768204 2660107 Positive_regulation EPHB2 HRG 23896512 2183723 Positive_regulation EPHB2 HSPB1 21364669 550148 Positive_regulation EPHB2 HSPG2 11250739 457026 Positive_regulation EPHB2 HSPG2 18404491 3088329 Positive_regulation EPHB2 HSPG2 18404491 3088337 Positive_regulation EPHB2 HSPG2 20071468 1773008 Positive_regulation EPHB2 HSPG2 20071468 1773080 Positive_regulation EPHB2 HSPG2 20981256 1217313 Positive_regulation EPHB2 HSPG2 22904641 490786 Positive_regulation EPHB2 HSPG2 22904641 490787 Positive_regulation EPHB2 HSPG2 22904641 490807 Positive_regulation EPHB2 HSPG2 23785422 2805765 Positive_regulation EPHB2 HSPG2 24586357 2924406 Positive_regulation EPHB2 HTR2A 18442977 1163763 Positive_regulation EPHB2 HTR2A 23372779 2746037 Positive_regulation EPHB2 HTR2B 19956756 2432683 Positive_regulation EPHB2 HTR7 22832728 3189188 Positive_regulation EPHB2 HTR7 25221471 871181 Positive_regulation EPHB2 IAPP 11602640 1521485 Positive_regulation EPHB2 IAPP 11602640 1521499 Positive_regulation EPHB2 IAPP 20870968 729569 Positive_regulation EPHB2 IAPP 20870968 729596 Positive_regulation EPHB2 IARS 22662132 2647042 Positive_regulation EPHB2 ICAM1 11121444 1265886 Positive_regulation EPHB2 ICAM1 16430772 3106044 Positive_regulation EPHB2 ICAM1 23434665 1101959 Positive_regulation EPHB2 ICAM2 11121444 1265887 Positive_regulation EPHB2 ICAM3 11121444 1265888 Positive_regulation EPHB2 ICAM4 11121444 1265889 Positive_regulation EPHB2 ICAM5 11121444 1265890 Positive_regulation EPHB2 ID2 24376712 2901915 Positive_regulation EPHB2 IER3 23704935 2796662 Positive_regulation EPHB2 IFI27 21114830 403439 Positive_regulation EPHB2 IFIT2 20565770 360379 Positive_regulation EPHB2 IFIT2 21853090 2543208 Positive_regulation EPHB2 IFITM1 20847954 1747913 Positive_regulation EPHB2 IFITM1 20847954 1747953 Positive_regulation EPHB2 IFNB1 22427889 2610573 Positive_regulation EPHB2 IFNG 21466707 3213972 Positive_regulation EPHB2 IFNGR1 24278569 3180057 Positive_regulation EPHB2 IGF1 12592371 422193 Positive_regulation EPHB2 IGF1 16365168 1326402 Positive_regulation EPHB2 IGF1 17622350 2377073 Positive_regulation EPHB2 IGF1 19039330 545807 Positive_regulation EPHB2 IGF1 19165200 431711 Positive_regulation EPHB2 IGF1 19834495 546419 Positive_regulation EPHB2 IGF1 21127754 2120733 Positive_regulation EPHB2 IGF1 21127754 2120742 Positive_regulation EPHB2 IGF1 21127754 2120753 Positive_regulation EPHB2 IGF1 21127754 2120757 Positive_regulation EPHB2 IGF1 21127754 2120758 Positive_regulation EPHB2 IGF1 21203386 2489698 Positive_regulation EPHB2 IGF1 21685939 2140438 Positive_regulation EPHB2 IGF1 21685939 2140445 Positive_regulation EPHB2 IGF1 21699731 1862523 Positive_regulation EPHB2 IGF1 21829671 2542276 Positive_regulation EPHB2 IGF1 21871133 1863072 Positive_regulation EPHB2 IGF1 21871133 1863090 Positive_regulation EPHB2 IGF1 21902831 3160657 Positive_regulation EPHB2 IGF1 21902831 3160711 Positive_regulation EPHB2 IGF1 22046506 1686734 Positive_regulation EPHB2 IGF1 22159423 1140658 Positive_regulation EPHB2 IGF1 22235273 2585711 Positive_regulation EPHB2 IGF1 22419908 951411 Positive_regulation EPHB2 IGF1 22470194 2179945 Positive_regulation EPHB2 IGF1 22536447 2622518 Positive_regulation EPHB2 IGF1 22586411 972457 Positive_regulation EPHB2 IGF1 22693602 2650847 Positive_regulation EPHB2 IGF1 22693602 2650848 Positive_regulation EPHB2 IGF1 23060802 959342 Positive_regulation EPHB2 IGF1 23082072 2121076 Positive_regulation EPHB2 IGF1 23082072 2121078 Positive_regulation EPHB2 IGF1 23267331 960515 Positive_regulation EPHB2 IGF1 23650507 2788820 Positive_regulation EPHB2 IGF1 23650573 851704 Positive_regulation EPHB2 IGF1 24188211 345803 Positive_regulation EPHB2 IGF1 24282611 2886422 Positive_regulation EPHB2 IGF1 24282611 2886461 Positive_regulation EPHB2 IGF1 24434591 787529 Positive_regulation EPHB2 IGF1 24434591 787530 Positive_regulation EPHB2 IGF1 24715976 848806 Positive_regulation EPHB2 IGF1 25054279 2991420 Positive_regulation EPHB2 IGF1 25295009 966102 Positive_regulation EPHB2 IGF1R 21278786 2137787 Positive_regulation EPHB2 IGF1R 21595894 467741 Positive_regulation EPHB2 IGF1R 21685939 2140337 Positive_regulation EPHB2 IGF1R 21685939 2140464 Positive_regulation EPHB2 IGF1R 22751693 723506 Positive_regulation EPHB2 IGF1R 24353828 2115353 Positive_regulation EPHB2 IGF1R 24384722 570750 Positive_regulation EPHB2 IGF1R 24970814 2194033 Positive_regulation EPHB2 IGF2 17988375 300880 Positive_regulation EPHB2 IGF2 17988375 300881 Positive_regulation EPHB2 IGF2 18413366 505640 Positive_regulation EPHB2 IGF2 20860815 1859248 Positive_regulation EPHB2 IGF2 20860815 1859254 Positive_regulation EPHB2 IGF2 21829671 2542277 Positive_regulation EPHB2 IGF2 21902831 3160658 Positive_regulation EPHB2 IGF2 21902831 3160712 Positive_regulation EPHB2 IGF2 22235273 2585712 Positive_regulation EPHB2 IGF2 22470194 2179946 Positive_regulation EPHB2 IGF2 23060802 959343 Positive_regulation EPHB2 IGF2 24282611 2886423 Positive_regulation EPHB2 IGF2 24932685 2980479 Positive_regulation EPHB2 IGFBP3 25601855 881532 Positive_regulation EPHB2 IGFBP5 23483937 2764796 Positive_regulation EPHB2 IGFBP5 23626478 1715091 Positive_regulation EPHB2 IGFBP5 23626478 1715094 Positive_regulation EPHB2 IGFBP6 25601855 881529 Positive_regulation EPHB2 IGFBP6 25601855 881534 Positive_regulation EPHB2 IGFBP6 25601855 881535 Positive_regulation EPHB2 IGKV1-12 21860608 1038263 Positive_regulation EPHB2 IKBKB 19252739 2406680 Positive_regulation EPHB2 IKBKB 23548063 367067 Positive_regulation EPHB2 IKBKB 23752269 1905015 Positive_regulation EPHB2 IKBKB 23752269 1905043 Positive_regulation EPHB2 IKBKG 19252739 2406681 Positive_regulation EPHB2 IKBKG 23752269 1905016 Positive_regulation EPHB2 IKBKG 23752269 1905044 Positive_regulation EPHB2 IL10 15841257 810578 Positive_regulation EPHB2 IL10 24260222 2882870 Positive_regulation EPHB2 IL10 24348050 2122498 Positive_regulation EPHB2 IL11 24348050 2122499 Positive_regulation EPHB2 IL11 25340554 3018707 Positive_regulation EPHB2 IL12A 15841257 810579 Positive_regulation EPHB2 IL12A 19426550 282627 Positive_regulation EPHB2 IL12A 21494377 1037958 Positive_regulation EPHB2 IL12A 24586980 2928635 Positive_regulation EPHB2 IL12B 15841257 810580 Positive_regulation EPHB2 IL12B 19426550 282628 Positive_regulation EPHB2 IL12B 21494377 1037959 Positive_regulation EPHB2 IL12B 24586980 2928636 Positive_regulation EPHB2 IL13 15907205 648916 Positive_regulation EPHB2 IL13 19116009 3109244 Positive_regulation EPHB2 IL13 24348050 2122500 Positive_regulation EPHB2 IL15 19237603 1554186 Positive_regulation EPHB2 IL15 19237603 1554199 Positive_regulation EPHB2 IL15 24348050 2122501 Positive_regulation EPHB2 IL15 25010048 2987745 Positive_regulation EPHB2 IL16 24348050 2122502 Positive_regulation EPHB2 IL17A 20976214 2479442 Positive_regulation EPHB2 IL17A 22171994 1864417 Positive_regulation EPHB2 IL17A 23202271 1958365 Positive_regulation EPHB2 IL17A 23202271 1958370 Positive_regulation EPHB2 IL17A 23956759 638346 Positive_regulation EPHB2 IL17A 24316750 3139088 Positive_regulation EPHB2 IL17A 24376862 2902564 Positive_regulation EPHB2 IL17A 24398084 131251 Positive_regulation EPHB2 IL17A 24586980 2928515 Positive_regulation EPHB2 IL17A 24586980 2928615 Positive_regulation EPHB2 IL17A 24586980 2928637 Positive_regulation EPHB2 IL17A 24586980 2928638 Positive_regulation EPHB2 IL17A 24892823 2975974 Positive_regulation EPHB2 IL17A 24892823 2976010 Positive_regulation EPHB2 IL17A 24980047 1576875 Positive_regulation EPHB2 IL18 20565717 119141 Positive_regulation EPHB2 IL18 22498979 3079519 Positive_regulation EPHB2 IL18 24348050 2122503 Positive_regulation EPHB2 IL19 24348050 2122504 Positive_regulation EPHB2 IL1A 10648566 1255386 Positive_regulation EPHB2 IL1A 10648566 1255387 Positive_regulation EPHB2 IL1A 10648566 1255388 Positive_regulation EPHB2 IL1A 10648566 1255398 Positive_regulation EPHB2 IL1A 10648566 1255399 Positive_regulation EPHB2 IL1A 10648566 1255400 Positive_regulation EPHB2 IL1A 11136824 1518278 Positive_regulation EPHB2 IL1A 12482999 1633737 Positive_regulation EPHB2 IL1A 16207331 104364 Positive_regulation EPHB2 IL1A 16209712 1844899 Positive_regulation EPHB2 IL1A 16209712 1844959 Positive_regulation EPHB2 IL1A 16504015 278974 Positive_regulation EPHB2 IL1A 16504015 278979 Positive_regulation EPHB2 IL1A 16740161 3107306 Positive_regulation EPHB2 IL1A 17105652 106839 Positive_regulation EPHB2 IL1A 17105652 106880 Positive_regulation EPHB2 IL1A 17386086 108164 Positive_regulation EPHB2 IL1A 17559674 108403 Positive_regulation EPHB2 IL1A 17559674 108436 Positive_regulation EPHB2 IL1A 19765281 117106 Positive_regulation EPHB2 IL1A 19808894 711201 Positive_regulation EPHB2 IL1A 19834602 2428790 Positive_regulation EPHB2 IL1A 19852794 1227705 Positive_regulation EPHB2 IL1A 20137095 375156 Positive_regulation EPHB2 IL1A 20137095 375162 Positive_regulation EPHB2 IL1A 20137095 375167 Positive_regulation EPHB2 IL1A 20137095 375174 Positive_regulation EPHB2 IL1A 20137095 375193 Positive_regulation EPHB2 IL1A 20195410 1711731 Positive_regulation EPHB2 IL1A 20830230 1711855 Positive_regulation EPHB2 IL1A 21232035 450967 Positive_regulation EPHB2 IL1A 21953341 90954 Positive_regulation EPHB2 IL1A 22219637 1913627 Positive_regulation EPHB2 IL1A 22824323 1664546 Positive_regulation EPHB2 IL1A 22909087 1626654 Positive_regulation EPHB2 IL1A 23396374 16825 Positive_regulation EPHB2 IL1A 23396374 16900 Positive_regulation EPHB2 IL1A 23549814 3233580 Positive_regulation EPHB2 IL1A 23549814 3233611 Positive_regulation EPHB2 IL1A 23827947 3136386 Positive_regulation EPHB2 IL1A 23847621 908164 Positive_regulation EPHB2 IL1A 23940616 2831881 Positive_regulation EPHB2 IL1A 23940616 2831882 Positive_regulation EPHB2 IL1A 23967327 2837428 Positive_regulation EPHB2 IL1A 23967327 2837430 Positive_regulation EPHB2 IL1A 24204851 2874429 Positive_regulation EPHB2 IL1A 24349175 2896995 Positive_regulation EPHB2 IL1A 24872832 825921 Positive_regulation EPHB2 IL1A 24923411 132744 Positive_regulation EPHB2 IL1A 25299270 174408 Positive_regulation EPHB2 IL1A 25299270 174416 Positive_regulation EPHB2 IL1A 25299270 174436 Positive_regulation EPHB2 IL1A PMC2833918 134429 Positive_regulation EPHB2 IL1RAP 20689814 2457833 Positive_regulation EPHB2 IL2 10545504 1251781 Positive_regulation EPHB2 IL2 17325202 1544675 Positive_regulation EPHB2 IL2 19025606 1646434 Positive_regulation EPHB2 IL2 23227982 534213 Positive_regulation EPHB2 IL2 24062984 946240 Positive_regulation EPHB2 IL2 24348050 2122505 Positive_regulation EPHB2 IL2 PMC3236909 3125399 Positive_regulation EPHB2 IL20 24348050 2122506 Positive_regulation EPHB2 IL21 23193414 1156318 Positive_regulation EPHB2 IL21 24348050 2122507 Positive_regulation EPHB2 IL22 21897855 2549854 Positive_regulation EPHB2 IL22 21897855 2549861 Positive_regulation EPHB2 IL22 21897855 2549862 Positive_regulation EPHB2 IL22 21897855 2549864 Positive_regulation EPHB2 IL22 23577040 1156410 Positive_regulation EPHB2 IL22 24348050 2122490 Positive_regulation EPHB2 IL24 24348050 2122488 Positive_regulation EPHB2 IL25 24348050 2122489 Positive_regulation EPHB2 IL26 24348050 2122494 Positive_regulation EPHB2 IL27 24348050 2122495 Positive_regulation EPHB2 IL27RA 22312192 1913965 Positive_regulation EPHB2 IL2RB 22666365 2647881 Positive_regulation EPHB2 IL2RB 22666365 2647882 Positive_regulation EPHB2 IL3 21706055 2140574 Positive_regulation EPHB2 IL3 21799948 1686419 Positive_regulation EPHB2 IL3 22873932 532962 Positive_regulation EPHB2 IL3 22873932 533055 Positive_regulation EPHB2 IL3 24348050 2122508 Positive_regulation EPHB2 IL31 24348050 2122496 Positive_regulation EPHB2 IL32 24348050 2122493 Positive_regulation EPHB2 IL33 20689814 2457832 Positive_regulation EPHB2 IL33 22246057 1086388 Positive_regulation EPHB2 IL33 22272250 2589424 Positive_regulation EPHB2 IL33 23418608 2754893 Positive_regulation EPHB2 IL33 23418608 2754911 Positive_regulation EPHB2 IL33 23418608 2754940 Positive_regulation EPHB2 IL33 24275094 1054259 Positive_regulation EPHB2 IL33 24275094 1054267 Positive_regulation EPHB2 IL33 24348050 2122492 Positive_regulation EPHB2 IL34 21861862 123850 Positive_regulation EPHB2 IL34 24348050 2122497 Positive_regulation EPHB2 IL37 24348050 2122491 Positive_regulation EPHB2 IL4 15907205 648917 Positive_regulation EPHB2 IL4 19426550 282629 Positive_regulation EPHB2 IL4 22761864 2658862 Positive_regulation EPHB2 IL4 22761864 2658895 Positive_regulation EPHB2 IL4 24348050 2122509 Positive_regulation EPHB2 IL5 24348050 2122510 Positive_regulation EPHB2 IL5 25121926 2997381 Positive_regulation EPHB2 IL5 25121926 2997414 Positive_regulation EPHB2 IL6 12010564 98800 Positive_regulation EPHB2 IL6 15210742 1533004 Positive_regulation EPHB2 IL6 19267906 1655650 Positive_regulation EPHB2 IL6 20830230 1711856 Positive_regulation EPHB2 IL6 21829524 2541565 Positive_regulation EPHB2 IL6 21829524 2541571 Positive_regulation EPHB2 IL6 21829524 2541577 Positive_regulation EPHB2 IL6 21829524 2541580 Positive_regulation EPHB2 IL6 21829524 2541581 Positive_regulation EPHB2 IL6 21829524 2541615 Positive_regulation EPHB2 IL6 21936900 1898458 Positive_regulation EPHB2 IL6 22269797 1898962 Positive_regulation EPHB2 IL6 22269797 1898963 Positive_regulation EPHB2 IL6 22269797 1898989 Positive_regulation EPHB2 IL6 22273495 1898997 Positive_regulation EPHB2 IL6 22319466 929206 Positive_regulation EPHB2 IL6 23342981 1030140 Positive_regulation EPHB2 IL6 24348050 2122511 Positive_regulation EPHB2 IL6 24533454 271668 Positive_regulation EPHB2 IL6 24913620 391461 Positive_regulation EPHB2 IL6 25473211 1636247 Positive_regulation EPHB2 IL6ST 11457894 1519965 Positive_regulation EPHB2 IL6ST 11457894 1519982 Positive_regulation EPHB2 IL6ST 12370259 1525025 Positive_regulation EPHB2 IL6ST 23933651 18446 Positive_regulation EPHB2 IL6ST 24612692 539530 Positive_regulation EPHB2 IL6ST 24643025 2935550 Positive_regulation EPHB2 IL6ST PMC4041476 746002 Positive_regulation EPHB2 IL7 17325202 1544676 Positive_regulation EPHB2 IL7 22046564 413352 Positive_regulation EPHB2 IL7 24348050 2122512 Positive_regulation EPHB2 IL8 19025606 1646435 Positive_regulation EPHB2 IL8 19709445 1625588 Positive_regulation EPHB2 IL8 23029099 2695231 Positive_regulation EPHB2 IL8 23800251 1627134 Positive_regulation EPHB2 IL8 24348050 2122513 Positive_regulation EPHB2 IL9 20169197 2441282 Positive_regulation EPHB2 IL9 24348050 2122514 Positive_regulation EPHB2 ILK 11696562 1276048 Positive_regulation EPHB2 INS 14568990 1299539 Positive_regulation EPHB2 INS 14568990 1299551 Positive_regulation EPHB2 INS 14568990 1299553 Positive_regulation EPHB2 INS 14568990 1299560 Positive_regulation EPHB2 INS 14568990 1299562 Positive_regulation EPHB2 INS 16365168 1326432 Positive_regulation EPHB2 INS 19108709 507893 Positive_regulation EPHB2 INS 19108709 507896 Positive_regulation EPHB2 INS 19108709 507910 Positive_regulation EPHB2 INS 19136652 707676 Positive_regulation EPHB2 INS 19357636 1902797 Positive_regulation EPHB2 INS 19357636 1902900 Positive_regulation EPHB2 INS 19357636 1902937 Positive_regulation EPHB2 INS 19357636 1902938 Positive_regulation EPHB2 INS 19357636 1902996 Positive_regulation EPHB2 INS 19357636 1903000 Positive_regulation EPHB2 INS 19590752 2421193 Positive_regulation EPHB2 INS 19648926 1971333 Positive_regulation EPHB2 INS 19808894 711409 Positive_regulation EPHB2 INS 19933999 711726 Positive_regulation EPHB2 INS 20333234 2313254 Positive_regulation EPHB2 INS 20807437 375721 Positive_regulation EPHB2 INS 21270272 717459 Positive_regulation EPHB2 INS 21270272 717464 Positive_regulation EPHB2 INS 21286247 1028349 Positive_regulation EPHB2 INS 21305007 2502228 Positive_regulation EPHB2 INS 21841811 13241 Positive_regulation EPHB2 INS 21841811 13263 Positive_regulation EPHB2 INS 21841811 13264 Positive_regulation EPHB2 INS 22031825 2565222 Positive_regulation EPHB2 INS 22111877 334585 Positive_regulation EPHB2 INS 22111877 334618 Positive_regulation EPHB2 INS 22111877 334619 Positive_regulation EPHB2 INS 22111877 334620 Positive_regulation EPHB2 INS 22111877 334747 Positive_regulation EPHB2 INS 22194983 2583598 Positive_regulation EPHB2 INS 22206009 2584139 Positive_regulation EPHB2 INS 22206009 2584140 Positive_regulation EPHB2 INS 22206009 2584144 Positive_regulation EPHB2 INS 22206009 2584154 Positive_regulation EPHB2 INS 22229094 154621 Positive_regulation EPHB2 INS 22229094 154626 Positive_regulation EPHB2 INS 22229094 154636 Positive_regulation EPHB2 INS 22389813 1152751 Positive_regulation EPHB2 INS 22470480 2614289 Positive_regulation EPHB2 INS 22470480 2614296 Positive_regulation EPHB2 INS 22470480 2614304 Positive_regulation EPHB2 INS 22649417 875449 Positive_regulation EPHB2 INS 22662132 2647033 Positive_regulation EPHB2 INS 22751693 723513 Positive_regulation EPHB2 INS 22763439 1988820 Positive_regulation EPHB2 INS 22961082 724525 Positive_regulation EPHB2 INS 22961086 724561 Positive_regulation EPHB2 INS 22961086 724562 Positive_regulation EPHB2 INS 22961086 724569 Positive_regulation EPHB2 INS 23024762 2689721 Positive_regulation EPHB2 INS 23024762 2689728 Positive_regulation EPHB2 INS 23112573 1915187 Positive_regulation EPHB2 INS 23112573 1915243 Positive_regulation EPHB2 INS 23237212 625267 Positive_regulation EPHB2 INS 23272222 2730193 Positive_regulation EPHB2 INS 23373726 96873 Positive_regulation EPHB2 INS 23437362 2756673 Positive_regulation EPHB2 INS 23437362 2756674 Positive_regulation EPHB2 INS 23437362 2756695 Positive_regulation EPHB2 INS 23468892 2760178 Positive_regulation EPHB2 INS 23561047 509487 Positive_regulation EPHB2 INS 23738035 2226032 Positive_regulation EPHB2 INS 23835326 727641 Positive_regulation EPHB2 INS 23847619 908123 Positive_regulation EPHB2 INS 24116164 2865615 Positive_regulation EPHB2 INS 24130927 204552 Positive_regulation EPHB2 INS 24276258 2244580 Positive_regulation EPHB2 INS 24282611 2886462 Positive_regulation EPHB2 INS 24391749 2904354 Positive_regulation EPHB2 INS 24423625 1727665 Positive_regulation EPHB2 INS 24423625 1727673 Positive_regulation EPHB2 INS 24423625 1727686 Positive_regulation EPHB2 INS 24434591 787592 Positive_regulation EPHB2 INS 24533136 2922375 Positive_regulation EPHB2 INS 24533136 2922382 Positive_regulation EPHB2 INS 24575362 20589 Positive_regulation EPHB2 INS 24575365 20593 Positive_regulation EPHB2 INS 24604418 1886296 Positive_regulation EPHB2 INS 24632852 2934392 Positive_regulation EPHB2 INS 24632852 2934401 Positive_regulation EPHB2 INS 24633815 3081946 Positive_regulation EPHB2 INS 24957684 2232009 Positive_regulation EPHB2 INS 24963636 2983411 Positive_regulation EPHB2 INS 25249538 2201855 Positive_regulation EPHB2 INS 25249545 2201889 Positive_regulation EPHB2 INS 25493642 3033419 Positive_regulation EPHB2 INS PMC3166768 2230818 Positive_regulation EPHB2 INSR 22403294 721701 Positive_regulation EPHB2 IPP 19888466 2430325 Positive_regulation EPHB2 IPP 19888466 2430328 Positive_regulation EPHB2 IQGAP1 17284314 1645194 Positive_regulation EPHB2 IQGAP3 24849319 2972484 Positive_regulation EPHB2 IQSEC1 22701712 2652226 Positive_regulation EPHB2 IRAK3 21390243 1049771 Positive_regulation EPHB2 IRS1 24818146 190388 Positive_regulation EPHB2 IRS2 21773024 1669822 Positive_regulation EPHB2 IRS2 21955917 621082 Positive_regulation EPHB2 ITCH 24708812 1843042 Positive_regulation EPHB2 ITCH 24708812 1843043 Positive_regulation EPHB2 ITCH 24708812 1843046 Positive_regulation EPHB2 ITGAL 23758320 151564 Positive_regulation EPHB2 ITGAM 24603876 2932594 Positive_regulation EPHB2 ITIH4 23742646 3121879 Positive_regulation EPHB2 ITK 24534190 1575052 Positive_regulation EPHB2 JAK1 20030801 526434 Positive_regulation EPHB2 JAK1 22347506 2596404 Positive_regulation EPHB2 JAK1 22649371 874788 Positive_regulation EPHB2 JAK1 24069558 1707279 Positive_regulation EPHB2 JAK2 19066310 707367 Positive_regulation EPHB2 JAK2 19066310 707368 Positive_regulation EPHB2 JAK2 20030801 526435 Positive_regulation EPHB2 JAK2 20838657 2272427 Positive_regulation EPHB2 JAK2 22347506 2596405 Positive_regulation EPHB2 JAK2 22649371 874789 Positive_regulation EPHB2 JAK2 22649371 874950 Positive_regulation EPHB2 JAK2 23216800 2113638 Positive_regulation EPHB2 JAK2 23383140 2748114 Positive_regulation EPHB2 JAK2 23761784 878690 Positive_regulation EPHB2 JAK2 24058789 1705652 Positive_regulation EPHB2 JAK2 24069558 1707280 Positive_regulation EPHB2 JAK3 20030801 526436 Positive_regulation EPHB2 JAK3 22347506 2596406 Positive_regulation EPHB2 JAK3 22649371 874790 Positive_regulation EPHB2 JAK3 24069558 1707281 Positive_regulation EPHB2 JMJD1C 24348429 972598 Positive_regulation EPHB2 JUN 11457888 1519846 Positive_regulation EPHB2 JUN 11506505 419684 Positive_regulation EPHB2 JUN 17105652 106840 Positive_regulation EPHB2 JUN 18983687 352495 Positive_regulation EPHB2 JUN 20868520 1859507 Positive_regulation EPHB2 JUN 21451502 1918229 Positive_regulation EPHB2 JUN 21887305 2549170 Positive_regulation EPHB2 JUN 21953341 90989 Positive_regulation EPHB2 JUN 22412999 2609993 Positive_regulation EPHB2 JUN 23060802 959361 Positive_regulation EPHB2 JUN 23150750 2225185 Positive_regulation EPHB2 JUN 23738035 2226033 Positive_regulation EPHB2 JUN 23912235 1109648 Positive_regulation EPHB2 JUN 23946780 2165321 Positive_regulation EPHB2 JUN 24987712 1622188 Positive_regulation EPHB2 JUN 25121739 2997338 Positive_regulation EPHB2 JUN 25250890 3010044 Positive_regulation EPHB2 JUN 25294825 2105157 Positive_regulation EPHB2 KCNH4 24049075 2093738 Positive_regulation EPHB2 KCNN4 25071444 869862 Positive_regulation EPHB2 KCNRG 20237900 3204923 Positive_regulation EPHB2 KDR 19114005 1503521 Positive_regulation EPHB2 KDR 19834490 546404 Positive_regulation EPHB2 KDR 20222950 255571 Positive_regulation EPHB2 KDR 23286511 587788 Positive_regulation EPHB2 KDR 23286511 587794 Positive_regulation EPHB2 KDR 23286511 587797 Positive_regulation EPHB2 KDR 23639442 700600 Positive_regulation EPHB2 KDR 23639442 700631 Positive_regulation EPHB2 KDR 23803732 543639 Positive_regulation EPHB2 KDR 24312323 2888512 Positive_regulation EPHB2 KDR 24358167 2898749 Positive_regulation EPHB2 KDR 24704994 806954 Positive_regulation EPHB2 KIDINS220 23999075 2235861 Positive_regulation EPHB2 KIF5B 25047660 1875852 Positive_regulation EPHB2 KIR2DS2 12591902 1526003 Positive_regulation EPHB2 KISS1R 18794340 1552069 Positive_regulation EPHB2 KISS1R 20886089 2476240 Positive_regulation EPHB2 KISS1R 20886089 2476241 Positive_regulation EPHB2 KISS1R 20886089 2476242 Positive_regulation EPHB2 KISS1R 20886089 2476243 Positive_regulation EPHB2 KISS1R 20886089 2476244 Positive_regulation EPHB2 KISS1R 20886089 2476245 Positive_regulation EPHB2 KISS1R 20886089 2476246 Positive_regulation EPHB2 KISS1R 20886089 2476271 Positive_regulation EPHB2 KISS1R 20886089 2476272 Positive_regulation EPHB2 KISS1R 20886089 2476273 Positive_regulation EPHB2 KIT 24713856 3141461 Positive_regulation EPHB2 KITLG 11435472 1519538 Positive_regulation EPHB2 KITLG 14981116 1531628 Positive_regulation EPHB2 KITLG 15149544 241476 Positive_regulation EPHB2 KITLG 23559126 838779 Positive_regulation EPHB2 KITLG 23709168 96675 Positive_regulation EPHB2 KL 21633782 477933 Positive_regulation EPHB2 KL 24695641 2948295 Positive_regulation EPHB2 KLRC1 19237603 1554174 Positive_regulation EPHB2 KLRC1 25291178 3012679 Positive_regulation EPHB2 KRAS 10471035 415100 Positive_regulation EPHB2 KRAS 12516548 2001296 Positive_regulation EPHB2 KRAS 15969750 1844732 Positive_regulation EPHB2 KRAS 17319972 1645347 Positive_regulation EPHB2 KRAS 17449939 1634808 Positive_regulation EPHB2 KRAS 17449939 1634809 Positive_regulation EPHB2 KRAS 17498287 999292 Positive_regulation EPHB2 KRAS 17498287 999295 Positive_regulation EPHB2 KRAS 18030338 2381002 Positive_regulation EPHB2 KRAS 18335053 2386984 Positive_regulation EPHB2 KRAS 18404483 3088020 Positive_regulation EPHB2 KRAS 18404483 3088051 Positive_regulation EPHB2 KRAS 18463697 2289742 Positive_regulation EPHB2 KRAS 18925939 2000818 Positive_regulation EPHB2 KRAS 18949068 2207995 Positive_regulation EPHB2 KRAS 19015320 1361480 Positive_regulation EPHB2 KRAS 19025606 1646456 Positive_regulation EPHB2 KRAS 19025606 1646459 Positive_regulation EPHB2 KRAS 19063885 850715 Positive_regulation EPHB2 KRAS 19137382 621159 Positive_regulation EPHB2 KRAS 19137382 621169 Positive_regulation EPHB2 KRAS 19238206 2406125 Positive_regulation EPHB2 KRAS 19492026 3401 Positive_regulation EPHB2 KRAS 19682393 1646602 Positive_regulation EPHB2 KRAS 19707311 175377 Positive_regulation EPHB2 KRAS 19804630 401928 Positive_regulation EPHB2 KRAS 19804630 401951 Positive_regulation EPHB2 KRAS 19804630 401977 Positive_regulation EPHB2 KRAS 19804630 402002 Positive_regulation EPHB2 KRAS 19861649 505910 Positive_regulation EPHB2 KRAS 19878585 254551 Positive_regulation EPHB2 KRAS 20003375 254812 Positive_regulation EPHB2 KRAS 20071468 1772938 Positive_regulation EPHB2 KRAS 20071468 1772939 Positive_regulation EPHB2 KRAS 20071468 1772995 Positive_regulation EPHB2 KRAS 20071468 1773009 Positive_regulation EPHB2 KRAS 20071468 1773010 Positive_regulation EPHB2 KRAS 20141835 516320 Positive_regulation EPHB2 KRAS 20162012 1089710 Positive_regulation EPHB2 KRAS 20179705 1984093 Positive_regulation EPHB2 KRAS 20532039 2452242 Positive_regulation EPHB2 KRAS 20549726 701642 Positive_regulation EPHB2 KRAS 20663127 386301 Positive_regulation EPHB2 KRAS 20802521 2135573 Positive_regulation EPHB2 KRAS 21042537 2479650 Positive_regulation EPHB2 KRAS 21364589 436531 Positive_regulation EPHB2 KRAS 21479172 2510914 Positive_regulation EPHB2 KRAS 21512581 2234287 Positive_regulation EPHB2 KRAS 21526160 2513803 Positive_regulation EPHB2 KRAS 21541658 616601 Positive_regulation EPHB2 KRAS 21756365 405130 Positive_regulation EPHB2 KRAS 21756365 405137 Positive_regulation EPHB2 KRAS 21831290 1505405 Positive_regulation EPHB2 KRAS 21980390 2560144 Positive_regulation EPHB2 KRAS 22102901 2572123 Positive_regulation EPHB2 KRAS 22319531 1067180 Positive_regulation EPHB2 KRAS 22327365 1928211 Positive_regulation EPHB2 KRAS 22363839 1687321 Positive_regulation EPHB2 KRAS 22384111 2605916 Positive_regulation EPHB2 KRAS 22384148 2607027 Positive_regulation EPHB2 KRAS 22419879 2120943 Positive_regulation EPHB2 KRAS 22523682 1687954 Positive_regulation EPHB2 KRAS 22971289 472099 Positive_regulation EPHB2 KRAS 23425254 3215211 Positive_regulation EPHB2 KRAS 23533771 1497059 Positive_regulation EPHB2 KRAS 23587357 734348 Positive_regulation EPHB2 KRAS 23626807 2784859 Positive_regulation EPHB2 KRAS 23690850 818987 Positive_regulation EPHB2 KRAS 23707528 614143 Positive_regulation EPHB2 KRAS 23741352 2800462 Positive_regulation EPHB2 KRAS 23758320 151519 Positive_regulation EPHB2 KRAS 23802073 2162520 Positive_regulation EPHB2 KRAS 23825558 2809658 Positive_regulation EPHB2 KRAS 23928793 3136656 Positive_regulation EPHB2 KRAS 24071646 566638 Positive_regulation EPHB2 KRAS 24071646 566646 Positive_regulation EPHB2 KRAS 24220297 1920139 Positive_regulation EPHB2 KRAS 24231770 545245 Positive_regulation EPHB2 KRAS 24265712 2884985 Positive_regulation EPHB2 KRAS 24330074 1482215 Positive_regulation EPHB2 KRAS 24396730 668237 Positive_regulation EPHB2 KRAS 24684778 1873583 Positive_regulation EPHB2 KRAS 24994118 2194891 Positive_regulation EPHB2 KRAS 25099740 1651936 Positive_regulation EPHB2 KRAS 25275324 3012020 Positive_regulation EPHB2 KRAS 25294825 2105196 Positive_regulation EPHB2 KRAS 25397617 3027237 Positive_regulation EPHB2 KRAS 9432981 1602478 Positive_regulation EPHB2 KRR1 21853090 2543202 Positive_regulation EPHB2 KRR1 22837689 1096626 Positive_regulation EPHB2 KSR1 21829671 2542278 Positive_regulation EPHB2 KSR1 21829671 2542286 Positive_regulation EPHB2 KSR1 21829671 2542295 Positive_regulation EPHB2 KSR1 22035226 528027 Positive_regulation EPHB2 KSR1 22206009 2584141 Positive_regulation EPHB2 KSR1 24918056 853893 Positive_regulation EPHB2 KSR1 24937142 851354 Positive_regulation EPHB2 L1CAM 22888955 734255 Positive_regulation EPHB2 LAMTOR2 17178906 1335619 Positive_regulation EPHB2 LAMTOR3 17178906 1335618 Positive_regulation EPHB2 LAMTOR3 19930650 526190 Positive_regulation EPHB2 LAMTOR3 19930650 526214 Positive_regulation EPHB2 LAMTOR3 19930650 526294 Positive_regulation EPHB2 LAMTOR3 22776333 532852 Positive_regulation EPHB2 LAMTOR3 23267331 960562 Positive_regulation EPHB2 LAT 12093866 1523720 Positive_regulation EPHB2 LAT 14624253 2255213 Positive_regulation EPHB2 LAT 22194750 1066963 Positive_regulation EPHB2 LBH 24023871 2843843 Positive_regulation EPHB2 LBH 24023871 2843844 Positive_regulation EPHB2 LBH 24023871 2843845 Positive_regulation EPHB2 LBH 24023871 2843846 Positive_regulation EPHB2 LBH 24023871 2843847 Positive_regulation EPHB2 LBH 24023871 2843857 Positive_regulation EPHB2 LBH 24023871 2843858 Positive_regulation EPHB2 LBH 24023871 2843859 Positive_regulation EPHB2 LBH 24023871 2843860 Positive_regulation EPHB2 LBH 24023871 2843861 Positive_regulation EPHB2 LBH 24023871 2843865 Positive_regulation EPHB2 LBH 24023871 2843866 Positive_regulation EPHB2 LBH 24023871 2843889 Positive_regulation EPHB2 LCK 10587355 1513511 Positive_regulation EPHB2 LCK 11956229 1280931 Positive_regulation EPHB2 LCK 11956229 1280951 Positive_regulation EPHB2 LCK 20126642 2439418 Positive_regulation EPHB2 LCK 20388118 147711 Positive_regulation EPHB2 LCK 22537596 3120146 Positive_regulation EPHB2 LCK 23071622 2703399 Positive_regulation EPHB2 LCK 23758320 151509 Positive_regulation EPHB2 LCK 23758320 151566 Positive_regulation EPHB2 LCK 24172637 3123964 Positive_regulation EPHB2 LCK PMC3236909 3125400 Positive_regulation EPHB2 LCP2 23758320 151510 Positive_regulation EPHB2 LCT 22039370 1038350 Positive_regulation EPHB2 LEO1 21298035 2499395 Positive_regulation EPHB2 LEO1 21298035 2499396 Positive_regulation EPHB2 LEO1 23911909 1637734 Positive_regulation EPHB2 LEO1 23911909 1637735 Positive_regulation EPHB2 LEO1 23911909 1637796 Positive_regulation EPHB2 LEO1 23911909 1637810 Positive_regulation EPHB2 LEO1 23911909 1637811 Positive_regulation EPHB2 LEO1 23911909 1637842 Positive_regulation EPHB2 LEO1 23911909 1637843 Positive_regulation EPHB2 LEO1 23911909 1637844 Positive_regulation EPHB2 LEO1 24886678 1618988 Positive_regulation EPHB2 LEO1 25261977 1510731 Positive_regulation EPHB2 LEP 19066310 707386 Positive_regulation EPHB2 LEP 19246598 708145 Positive_regulation EPHB2 LEP 19888448 2430226 Positive_regulation EPHB2 LEP 20870968 729597 Positive_regulation EPHB2 LEP 21286276 667793 Positive_regulation EPHB2 LEP 22690216 1674016 Positive_regulation EPHB2 LEP 23028384 3075922 Positive_regulation EPHB2 LEP 23028384 3075952 Positive_regulation EPHB2 LEP 23300886 2737138 Positive_regulation EPHB2 LEP 23308070 937557 Positive_regulation EPHB2 LEP 23308070 937561 Positive_regulation EPHB2 LEP 23308070 937576 Positive_regulation EPHB2 LEP 23308070 937604 Positive_regulation EPHB2 LEP 23308070 937605 Positive_regulation EPHB2 LEP 24340098 2894856 Positive_regulation EPHB2 LEP 24340098 2894963 Positive_regulation EPHB2 LEP 25177272 871150 Positive_regulation EPHB2 LEP 25403445 3147009 Positive_regulation EPHB2 LEP 25403445 3147010 Positive_regulation EPHB2 LEP 25403445 3147042 Positive_regulation EPHB2 LEP 25403445 3147053 Positive_regulation EPHB2 LEP 25403445 3147067 Positive_regulation EPHB2 LEP 25403445 3147075 Positive_regulation EPHB2 LEP PMC2833530 134197 Positive_regulation EPHB2 LGALS1 18794340 1552070 Positive_regulation EPHB2 LGALS1 20700538 2458213 Positive_regulation EPHB2 LGALS1 22237208 553910 Positive_regulation EPHB2 LGALS1 22237208 553919 Positive_regulation EPHB2 LGALS1 24788652 2959206 Positive_regulation EPHB2 LGALS1 24885890 273554 Positive_regulation EPHB2 LGALS8 23847619 908134 Positive_regulation EPHB2 LGALS8 25115182 361436 Positive_regulation EPHB2 LHCGR 24375413 1208768 Positive_regulation EPHB2 LIF 19267906 1655651 Positive_regulation EPHB2 LIF 22143885 1566343 Positive_regulation EPHB2 LIF 23642364 615800 Positive_regulation EPHB2 LIF 24710148 986012 Positive_regulation EPHB2 LIF 25340554 3018698 Positive_regulation EPHB2 LIF 25340554 3018708 Positive_regulation EPHB2 LILRB1 24349829 478296 Positive_regulation EPHB2 LILRB2 24096486 2153884 Positive_regulation EPHB2 LIMK1 21682918 1862484 Positive_regulation EPHB2 LIMK1 21682918 1862485 Positive_regulation EPHB2 LIN37 21931179 29662 Positive_regulation EPHB2 LIN52 21931179 29658 Positive_regulation EPHB2 LIN54 21931179 29659 Positive_regulation EPHB2 LIN9 21931179 29660 Positive_regulation EPHB2 LPA 11897012 389915 Positive_regulation EPHB2 LPA 15685238 425286 Positive_regulation EPHB2 LPA 15939762 1320814 Positive_regulation EPHB2 LPA 18404483 3088021 Positive_regulation EPHB2 LPA 18762583 1357059 Positive_regulation EPHB2 LPA 19077254 385112 Positive_regulation EPHB2 LPA 19077254 385121 Positive_regulation EPHB2 LPA 19077254 385141 Positive_regulation EPHB2 LPA 19742132 1088766 Positive_regulation EPHB2 LPA 19742132 1088793 Positive_regulation EPHB2 LPA 21209852 2491367 Positive_regulation EPHB2 LPA 21209852 2491368 Positive_regulation EPHB2 LPA 21209852 2491369 Positive_regulation EPHB2 LPA 21209852 2491370 Positive_regulation EPHB2 LPA 21209852 2491371 Positive_regulation EPHB2 LPA 21209852 2491372 Positive_regulation EPHB2 LPA 21209852 2491373 Positive_regulation EPHB2 LPA 21209852 2491401 Positive_regulation EPHB2 LPA 21209852 2491407 Positive_regulation EPHB2 LPA 21209852 2491408 Positive_regulation EPHB2 LPA 21209852 2491417 Positive_regulation EPHB2 LPA 21209852 2491422 Positive_regulation EPHB2 LPA 21209852 2491448 Positive_regulation EPHB2 LPA 21209852 2491449 Positive_regulation EPHB2 LPA 21209852 2491464 Positive_regulation EPHB2 LPA 21406114 286542 Positive_regulation EPHB2 LPA 21406114 286557 Positive_regulation EPHB2 LPA 21686182 1091055 Positive_regulation EPHB2 LPA 22639801 212813 Positive_regulation EPHB2 LPA 22639801 212814 Positive_regulation EPHB2 LPA 22639801 212816 Positive_regulation EPHB2 LPA 22904641 490808 Positive_regulation EPHB2 LPA 23145131 2716103 Positive_regulation EPHB2 LPA 23209312 1570350 Positive_regulation EPHB2 LPA 23326327 2739800 Positive_regulation EPHB2 LPA 23706742 517229 Positive_regulation EPHB2 LPA 23706742 517300 Positive_regulation EPHB2 LPA 24251962 1481944 Positive_regulation EPHB2 LPA 24744506 1758210 Positive_regulation EPHB2 LPA 24928086 273897 Positive_regulation EPHB2 LPA 24928086 273912 Positive_regulation EPHB2 LPA 24928086 273916 Positive_regulation EPHB2 LPA 24928086 273919 Positive_regulation EPHB2 LPA 24928086 273970 Positive_regulation EPHB2 LRP1 12821648 1293163 Positive_regulation EPHB2 LRP1 16908670 1331934 Positive_regulation EPHB2 LRP1 16908670 1331952 Positive_regulation EPHB2 LRP1 20644732 2456016 Positive_regulation EPHB2 LRP1 20644732 2456017 Positive_regulation EPHB2 LRP1 20644732 2456018 Positive_regulation EPHB2 LRP1 20644732 2456073 Positive_regulation EPHB2 LRP1 20644732 2456074 Positive_regulation EPHB2 LRP1 20644732 2456129 Positive_regulation EPHB2 LRP1 20644732 2456155 Positive_regulation EPHB2 LRP1 20644732 2456161 Positive_regulation EPHB2 LRP1 24805867 504520 Positive_regulation EPHB2 LRP10 12821648 1293159 Positive_regulation EPHB2 LRP11 12821648 1293160 Positive_regulation EPHB2 LRP12 12821648 1293161 Positive_regulation EPHB2 LRP2 12821648 1293164 Positive_regulation EPHB2 LRP3 12821648 1293165 Positive_regulation EPHB2 LRP4 12821648 1293166 Positive_regulation EPHB2 LRP5 12821648 1293167 Positive_regulation EPHB2 LRP5 20011526 2433527 Positive_regulation EPHB2 LRP6 12821648 1293168 Positive_regulation EPHB2 LRP8 12821648 1293169 Positive_regulation EPHB2 LRPPRC 17616983 2289422 Positive_regulation EPHB2 LTA 24971655 2984748 Positive_regulation EPHB2 LTB 15249579 1311076 Positive_regulation EPHB2 LTB 23569388 2121194 Positive_regulation EPHB2 LTB 23799854 440996 Positive_regulation EPHB2 LTB 24842369 1576329 Positive_regulation EPHB2 LTB4R2 23799854 440990 Positive_regulation EPHB2 LTB4R2 23799854 440995 Positive_regulation EPHB2 LTF 21610072 1191632 Positive_regulation EPHB2 LTF 21610072 1191633 Positive_regulation EPHB2 LTF 21610072 1191756 Positive_regulation EPHB2 LUM 24367547 2900208 Positive_regulation EPHB2 LYN 22731636 1866176 Positive_regulation EPHB2 MALT1 23586039 180946 Positive_regulation EPHB2 MALT1 23586039 181090 Positive_regulation EPHB2 MALT1 25479338 3032224 Positive_regulation EPHB2 MAP1LC3A 24240988 1939492 Positive_regulation EPHB2 MAP1LC3A 24240988 1939518 Positive_regulation EPHB2 MAP2K1 10330402 1246193 Positive_regulation EPHB2 MAP2K1 10477763 1249253 Positive_regulation EPHB2 MAP2K1 10477763 1249336 Positive_regulation EPHB2 MAP2K1 10648571 1255601 Positive_regulation EPHB2 MAP2K1 10648571 1255633 Positive_regulation EPHB2 MAP2K1 11309409 1269487 Positive_regulation EPHB2 MAP2K1 11425867 1271717 Positive_regulation EPHB2 MAP2K1 11435472 1519539 Positive_regulation EPHB2 MAP2K1 11435472 1519620 Positive_regulation EPHB2 MAP2K1 12370087 225130 Positive_regulation EPHB2 MAP2K1 14744999 1305408 Positive_regulation EPHB2 MAP2K1 14981092 1306412 Positive_regulation EPHB2 MAP2K1 15123736 1308382 Positive_regulation EPHB2 MAP2K1 15699069 1534482 Positive_regulation EPHB2 MAP2K1 16278666 426778 Positive_regulation EPHB2 MAP2K1 16351709 1845012 Positive_regulation EPHB2 MAP2K1 16365168 1326403 Positive_regulation EPHB2 MAP2K1 16787538 3096292 Positive_regulation EPHB2 MAP2K1 17178906 1335620 Positive_regulation EPHB2 MAP2K1 17631690 1896885 Positive_regulation EPHB2 MAP2K1 18159242 2381537 Positive_regulation EPHB2 MAP2K1 18332218 1349910 Positive_regulation EPHB2 MAP2K1 18335053 2386976 Positive_regulation EPHB2 MAP2K1 18404483 3087907 Positive_regulation EPHB2 MAP2K1 18404483 3088073 Positive_regulation EPHB2 MAP2K1 18460189 2232716 Positive_regulation EPHB2 MAP2K1 19018286 2400983 Positive_regulation EPHB2 MAP2K1 19182807 1952236 Positive_regulation EPHB2 MAP2K1 19252739 2406670 Positive_regulation EPHB2 MAP2K1 19252739 2406682 Positive_regulation EPHB2 MAP2K1 19383130 525240 Positive_regulation EPHB2 MAP2K1 19390590 2415319 Positive_regulation EPHB2 MAP2K1 19404317 1719326 Positive_regulation EPHB2 MAP2K1 19707375 175655 Positive_regulation EPHB2 MAP2K1 19878579 283632 Positive_regulation EPHB2 MAP2K1 20100173 212577 Positive_regulation EPHB2 MAP2K1 20100173 212582 Positive_regulation EPHB2 MAP2K1 20403177 659554 Positive_regulation EPHB2 MAP2K1 20462959 1776135 Positive_regulation EPHB2 MAP2K1 20711231 2133606 Positive_regulation EPHB2 MAP2K1 20818427 2136129 Positive_regulation EPHB2 MAP2K1 20819940 1379032 Positive_regulation EPHB2 MAP2K1 20838657 2272353 Positive_regulation EPHB2 MAP2K1 20868520 1859529 Positive_regulation EPHB2 MAP2K1 21278786 2137746 Positive_regulation EPHB2 MAP2K1 21278786 2137747 Positive_regulation EPHB2 MAP2K1 21365009 2504965 Positive_regulation EPHB2 MAP2K1 21386996 2506124 Positive_regulation EPHB2 MAP2K1 21505228 2175890 Positive_regulation EPHB2 MAP2K1 21505228 2175904 Positive_regulation EPHB2 MAP2K1 21505228 2175912 Positive_regulation EPHB2 MAP2K1 21505228 2175929 Positive_regulation EPHB2 MAP2K1 21559502 2520072 Positive_regulation EPHB2 MAP2K1 21642949 12876 Positive_regulation EPHB2 MAP2K1 21837281 2001959 Positive_regulation EPHB2 MAP2K1 21860067 2176431 Positive_regulation EPHB2 MAP2K1 21876842 2234355 Positive_regulation EPHB2 MAP2K1 22077956 3091382 Positive_regulation EPHB2 MAP2K1 22087839 681968 Positive_regulation EPHB2 MAP2K1 22087839 681976 Positive_regulation EPHB2 MAP2K1 22087839 682003 Positive_regulation EPHB2 MAP2K1 22091401 1831040 Positive_regulation EPHB2 MAP2K1 22159586 600516 Positive_regulation EPHB2 MAP2K1 22187659 1079057 Positive_regulation EPHB2 MAP2K1 22448169 3075834 Positive_regulation EPHB2 MAP2K1 22577355 2296709 Positive_regulation EPHB2 MAP2K1 22629454 2646572 Positive_regulation EPHB2 MAP2K1 22745804 2656646 Positive_regulation EPHB2 MAP2K1 22783258 902304 Positive_regulation EPHB2 MAP2K1 22808290 2665566 Positive_regulation EPHB2 MAP2K1 22870983 288875 Positive_regulation EPHB2 MAP2K1 22880048 2673696 Positive_regulation EPHB2 MAP2K1 23009336 1866992 Positive_regulation EPHB2 MAP2K1 23060802 959289 Positive_regulation EPHB2 MAP2K1 23060802 959405 Positive_regulation EPHB2 MAP2K1 23133759 1079513 Positive_regulation EPHB2 MAP2K1 23233790 1915349 Positive_regulation EPHB2 MAP2K1 23237773 2182000 Positive_regulation EPHB2 MAP2K1 23382384 1206233 Positive_regulation EPHB2 MAP2K1 23434660 1101904 Positive_regulation EPHB2 MAP2K1 23453810 1878022 Positive_regulation EPHB2 MAP2K1 23505453 2766114 Positive_regulation EPHB2 MAP2K1 23658559 883840 Positive_regulation EPHB2 MAP2K1 23675062 1064483 Positive_regulation EPHB2 MAP2K1 23704935 2796663 Positive_regulation EPHB2 MAP2K1 23704935 2796664 Positive_regulation EPHB2 MAP2K1 23762493 2804152 Positive_regulation EPHB2 MAP2K1 23782265 151701 Positive_regulation EPHB2 MAP2K1 23976985 2837979 Positive_regulation EPHB2 MAP2K1 24045785 3137162 Positive_regulation EPHB2 MAP2K1 24053798 290131 Positive_regulation EPHB2 MAP2K1 24086653 2855429 Positive_regulation EPHB2 MAP2K1 24223225 2876731 Positive_regulation EPHB2 MAP2K1 24416349 2907641 Positive_regulation EPHB2 MAP2K1 24550252 752939 Positive_regulation EPHB2 MAP2K1 24550252 752953 Positive_regulation EPHB2 MAP2K1 24550835 963552 Positive_regulation EPHB2 MAP2K1 24608898 2932849 Positive_regulation EPHB2 MAP2K1 24710474 618055 Positive_regulation EPHB2 MAP2K1 24823877 1126533 Positive_regulation EPHB2 MAP2K1 24849047 1942128 Positive_regulation EPHB2 MAP2K1 24937142 851308 Positive_regulation EPHB2 MAP2K1 24937142 851401 Positive_regulation EPHB2 MAP2K1 24980047 1576906 Positive_regulation EPHB2 MAP2K1 24991762 576769 Positive_regulation EPHB2 MAP2K1 25126479 212367 Positive_regulation EPHB2 MAP2K1 25226519 3007909 Positive_regulation EPHB2 MAP2K1 25479605 3032498 Positive_regulation EPHB2 MAP2K1 8996240 1599782 Positive_regulation EPHB2 MAP2K2 10477763 1249254 Positive_regulation EPHB2 MAP2K2 10477763 1249337 Positive_regulation EPHB2 MAP2K2 10648571 1255602 Positive_regulation EPHB2 MAP2K2 10648571 1255634 Positive_regulation EPHB2 MAP2K2 11309409 1269488 Positive_regulation EPHB2 MAP2K2 11435472 1519540 Positive_regulation EPHB2 MAP2K2 11435472 1519621 Positive_regulation EPHB2 MAP2K2 12370087 225131 Positive_regulation EPHB2 MAP2K2 14744999 1305409 Positive_regulation EPHB2 MAP2K2 14981092 1306413 Positive_regulation EPHB2 MAP2K2 15123736 1308383 Positive_regulation EPHB2 MAP2K2 15699069 1534483 Positive_regulation EPHB2 MAP2K2 16278666 426779 Positive_regulation EPHB2 MAP2K2 16351709 1845013 Positive_regulation EPHB2 MAP2K2 16365168 1326404 Positive_regulation EPHB2 MAP2K2 16787538 3096293 Positive_regulation EPHB2 MAP2K2 17631690 1896886 Positive_regulation EPHB2 MAP2K2 18159242 2381538 Positive_regulation EPHB2 MAP2K2 18332218 1349911 Positive_regulation EPHB2 MAP2K2 18335053 2386977 Positive_regulation EPHB2 MAP2K2 18404483 3087908 Positive_regulation EPHB2 MAP2K2 18404483 3088074 Positive_regulation EPHB2 MAP2K2 19018286 2400984 Positive_regulation EPHB2 MAP2K2 19383130 525241 Positive_regulation EPHB2 MAP2K2 19390590 2415320 Positive_regulation EPHB2 MAP2K2 19707375 175656 Positive_regulation EPHB2 MAP2K2 19878579 283633 Positive_regulation EPHB2 MAP2K2 20100173 212578 Positive_regulation EPHB2 MAP2K2 20100173 212583 Positive_regulation EPHB2 MAP2K2 20403177 659555 Positive_regulation EPHB2 MAP2K2 20462959 1776136 Positive_regulation EPHB2 MAP2K2 20818427 2136130 Positive_regulation EPHB2 MAP2K2 20819940 1379033 Positive_regulation EPHB2 MAP2K2 20868520 1859530 Positive_regulation EPHB2 MAP2K2 21278786 2137748 Positive_regulation EPHB2 MAP2K2 21365009 2504966 Positive_regulation EPHB2 MAP2K2 21386996 2506125 Positive_regulation EPHB2 MAP2K2 21505228 2175891 Positive_regulation EPHB2 MAP2K2 21505228 2175905 Positive_regulation EPHB2 MAP2K2 21505228 2175913 Positive_regulation EPHB2 MAP2K2 21505228 2175930 Positive_regulation EPHB2 MAP2K2 21559502 2520073 Positive_regulation EPHB2 MAP2K2 21642949 12877 Positive_regulation EPHB2 MAP2K2 21837281 2001960 Positive_regulation EPHB2 MAP2K2 21860067 2176432 Positive_regulation EPHB2 MAP2K2 21876842 2234356 Positive_regulation EPHB2 MAP2K2 22077956 3091383 Positive_regulation EPHB2 MAP2K2 22087839 681969 Positive_regulation EPHB2 MAP2K2 22087839 681977 Positive_regulation EPHB2 MAP2K2 22087839 682004 Positive_regulation EPHB2 MAP2K2 22091401 1831041 Positive_regulation EPHB2 MAP2K2 22159586 600517 Positive_regulation EPHB2 MAP2K2 22187659 1079058 Positive_regulation EPHB2 MAP2K2 22448169 3075835 Positive_regulation EPHB2 MAP2K2 22577355 2296710 Positive_regulation EPHB2 MAP2K2 22629454 2646573 Positive_regulation EPHB2 MAP2K2 22745804 2656647 Positive_regulation EPHB2 MAP2K2 22783258 902305 Positive_regulation EPHB2 MAP2K2 22870983 288876 Positive_regulation EPHB2 MAP2K2 22880048 2673697 Positive_regulation EPHB2 MAP2K2 23009336 1866993 Positive_regulation EPHB2 MAP2K2 23060802 959290 Positive_regulation EPHB2 MAP2K2 23060802 959406 Positive_regulation EPHB2 MAP2K2 23237773 2182001 Positive_regulation EPHB2 MAP2K2 23434660 1101905 Positive_regulation EPHB2 MAP2K2 23453810 1878023 Positive_regulation EPHB2 MAP2K2 23658559 883841 Positive_regulation EPHB2 MAP2K2 23675062 1064484 Positive_regulation EPHB2 MAP2K2 23704935 2796665 Positive_regulation EPHB2 MAP2K2 23704935 2796666 Positive_regulation EPHB2 MAP2K2 23762493 2804153 Positive_regulation EPHB2 MAP2K2 23782265 151702 Positive_regulation EPHB2 MAP2K2 23976985 2837980 Positive_regulation EPHB2 MAP2K2 24045785 3137163 Positive_regulation EPHB2 MAP2K2 24086653 2855430 Positive_regulation EPHB2 MAP2K2 24223225 2876732 Positive_regulation EPHB2 MAP2K2 24416349 2907642 Positive_regulation EPHB2 MAP2K2 24550252 752940 Positive_regulation EPHB2 MAP2K2 24550252 752954 Positive_regulation EPHB2 MAP2K2 24550835 963553 Positive_regulation EPHB2 MAP2K2 24608898 2932850 Positive_regulation EPHB2 MAP2K2 24710474 618056 Positive_regulation EPHB2 MAP2K2 24823877 1126534 Positive_regulation EPHB2 MAP2K2 24849047 1942129 Positive_regulation EPHB2 MAP2K2 24937142 851309 Positive_regulation EPHB2 MAP2K2 24937142 851402 Positive_regulation EPHB2 MAP2K2 25126479 212368 Positive_regulation EPHB2 MAP2K2 25226519 3007910 Positive_regulation EPHB2 MAP2K2 25479605 3032499 Positive_regulation EPHB2 MAP2K2 8996240 1599783 Positive_regulation EPHB2 MAP2K3 10477763 1249255 Positive_regulation EPHB2 MAP2K3 10477763 1249338 Positive_regulation EPHB2 MAP2K3 10648571 1255603 Positive_regulation EPHB2 MAP2K3 10648571 1255635 Positive_regulation EPHB2 MAP2K3 11309409 1269489 Positive_regulation EPHB2 MAP2K3 11435472 1519541 Positive_regulation EPHB2 MAP2K3 11435472 1519622 Positive_regulation EPHB2 MAP2K3 12370087 225132 Positive_regulation EPHB2 MAP2K3 14744999 1305410 Positive_regulation EPHB2 MAP2K3 14981092 1306414 Positive_regulation EPHB2 MAP2K3 15123736 1308384 Positive_regulation EPHB2 MAP2K3 15699069 1534484 Positive_regulation EPHB2 MAP2K3 16278666 426780 Positive_regulation EPHB2 MAP2K3 16365168 1326405 Positive_regulation EPHB2 MAP2K3 16787538 3096294 Positive_regulation EPHB2 MAP2K3 17631690 1896887 Positive_regulation EPHB2 MAP2K3 18159242 2381539 Positive_regulation EPHB2 MAP2K3 18332218 1349912 Positive_regulation EPHB2 MAP2K3 18335053 2386978 Positive_regulation EPHB2 MAP2K3 18404483 3087909 Positive_regulation EPHB2 MAP2K3 18404483 3088075 Positive_regulation EPHB2 MAP2K3 19018286 2400985 Positive_regulation EPHB2 MAP2K3 19252739 2406671 Positive_regulation EPHB2 MAP2K3 19383130 525242 Positive_regulation EPHB2 MAP2K3 19390590 2415321 Positive_regulation EPHB2 MAP2K3 19707375 175657 Positive_regulation EPHB2 MAP2K3 19878579 283634 Positive_regulation EPHB2 MAP2K3 20403177 659556 Positive_regulation EPHB2 MAP2K3 20462959 1776137 Positive_regulation EPHB2 MAP2K3 20818427 2136131 Positive_regulation EPHB2 MAP2K3 20819940 1379034 Positive_regulation EPHB2 MAP2K3 20868520 1859531 Positive_regulation EPHB2 MAP2K3 21278786 2137749 Positive_regulation EPHB2 MAP2K3 21386996 2506126 Positive_regulation EPHB2 MAP2K3 21505228 2175892 Positive_regulation EPHB2 MAP2K3 21505228 2175906 Positive_regulation EPHB2 MAP2K3 21505228 2175914 Positive_regulation EPHB2 MAP2K3 21505228 2175931 Positive_regulation EPHB2 MAP2K3 21559502 2520074 Positive_regulation EPHB2 MAP2K3 21642949 12878 Positive_regulation EPHB2 MAP2K3 21837281 2001961 Positive_regulation EPHB2 MAP2K3 21860067 2176433 Positive_regulation EPHB2 MAP2K3 21876842 2234357 Positive_regulation EPHB2 MAP2K3 22077956 3091384 Positive_regulation EPHB2 MAP2K3 22087839 681970 Positive_regulation EPHB2 MAP2K3 22087839 681978 Positive_regulation EPHB2 MAP2K3 22087839 682005 Positive_regulation EPHB2 MAP2K3 22091401 1831042 Positive_regulation EPHB2 MAP2K3 22159586 600518 Positive_regulation EPHB2 MAP2K3 22187659 1079059 Positive_regulation EPHB2 MAP2K3 22448169 3075836 Positive_regulation EPHB2 MAP2K3 22577355 2296711 Positive_regulation EPHB2 MAP2K3 22745804 2656648 Positive_regulation EPHB2 MAP2K3 22783258 902306 Positive_regulation EPHB2 MAP2K3 22870983 288877 Positive_regulation EPHB2 MAP2K3 22880048 2673698 Positive_regulation EPHB2 MAP2K3 23009336 1866994 Positive_regulation EPHB2 MAP2K3 23060802 959291 Positive_regulation EPHB2 MAP2K3 23060802 959407 Positive_regulation EPHB2 MAP2K3 23233790 1915350 Positive_regulation EPHB2 MAP2K3 23237773 2182002 Positive_regulation EPHB2 MAP2K3 23434660 1101906 Positive_regulation EPHB2 MAP2K3 23453810 1878024 Positive_regulation EPHB2 MAP2K3 23658559 883842 Positive_regulation EPHB2 MAP2K3 23675062 1064485 Positive_regulation EPHB2 MAP2K3 23704935 2796667 Positive_regulation EPHB2 MAP2K3 23704935 2796668 Positive_regulation EPHB2 MAP2K3 23762493 2804154 Positive_regulation EPHB2 MAP2K3 23782265 151703 Positive_regulation EPHB2 MAP2K3 23976985 2837981 Positive_regulation EPHB2 MAP2K3 24086653 2855431 Positive_regulation EPHB2 MAP2K3 24223225 2876733 Positive_regulation EPHB2 MAP2K3 24416349 2907643 Positive_regulation EPHB2 MAP2K3 24550252 752941 Positive_regulation EPHB2 MAP2K3 24550252 752955 Positive_regulation EPHB2 MAP2K3 24550835 963554 Positive_regulation EPHB2 MAP2K3 24608898 2932851 Positive_regulation EPHB2 MAP2K3 24710474 618057 Positive_regulation EPHB2 MAP2K3 24823877 1126535 Positive_regulation EPHB2 MAP2K3 24849047 1942130 Positive_regulation EPHB2 MAP2K3 24937142 851310 Positive_regulation EPHB2 MAP2K3 24937142 851403 Positive_regulation EPHB2 MAP2K3 25126479 212369 Positive_regulation EPHB2 MAP2K3 25226519 3007911 Positive_regulation EPHB2 MAP2K3 25479605 3032500 Positive_regulation EPHB2 MAP2K3 8996240 1599784 Positive_regulation EPHB2 MAP2K4 10477763 1249256 Positive_regulation EPHB2 MAP2K4 10477763 1249339 Positive_regulation EPHB2 MAP2K4 10648571 1255604 Positive_regulation EPHB2 MAP2K4 10648571 1255636 Positive_regulation EPHB2 MAP2K4 11309409 1269490 Positive_regulation EPHB2 MAP2K4 11435472 1519542 Positive_regulation EPHB2 MAP2K4 11435472 1519623 Positive_regulation EPHB2 MAP2K4 12370087 225133 Positive_regulation EPHB2 MAP2K4 14744999 1305411 Positive_regulation EPHB2 MAP2K4 14981092 1306415 Positive_regulation EPHB2 MAP2K4 15123736 1308385 Positive_regulation EPHB2 MAP2K4 15699069 1534485 Positive_regulation EPHB2 MAP2K4 16278666 426781 Positive_regulation EPHB2 MAP2K4 16365168 1326406 Positive_regulation EPHB2 MAP2K4 16787538 3096295 Positive_regulation EPHB2 MAP2K4 17631690 1896888 Positive_regulation EPHB2 MAP2K4 18159242 2381540 Positive_regulation EPHB2 MAP2K4 18332218 1349913 Positive_regulation EPHB2 MAP2K4 18335053 2386979 Positive_regulation EPHB2 MAP2K4 18404483 3087910 Positive_regulation EPHB2 MAP2K4 18404483 3088076 Positive_regulation EPHB2 MAP2K4 19018286 2400986 Positive_regulation EPHB2 MAP2K4 19252739 2406672 Positive_regulation EPHB2 MAP2K4 19383130 525243 Positive_regulation EPHB2 MAP2K4 19390590 2415322 Positive_regulation EPHB2 MAP2K4 19707375 175658 Positive_regulation EPHB2 MAP2K4 19878579 283635 Positive_regulation EPHB2 MAP2K4 20403177 659557 Positive_regulation EPHB2 MAP2K4 20462959 1776138 Positive_regulation EPHB2 MAP2K4 20818427 2136132 Positive_regulation EPHB2 MAP2K4 20819940 1379035 Positive_regulation EPHB2 MAP2K4 20868520 1859532 Positive_regulation EPHB2 MAP2K4 21278786 2137750 Positive_regulation EPHB2 MAP2K4 21386996 2506127 Positive_regulation EPHB2 MAP2K4 21505228 2175893 Positive_regulation EPHB2 MAP2K4 21505228 2175907 Positive_regulation EPHB2 MAP2K4 21505228 2175915 Positive_regulation EPHB2 MAP2K4 21505228 2175932 Positive_regulation EPHB2 MAP2K4 21559502 2520075 Positive_regulation EPHB2 MAP2K4 21642949 12879 Positive_regulation EPHB2 MAP2K4 21837281 2001962 Positive_regulation EPHB2 MAP2K4 21860067 2176434 Positive_regulation EPHB2 MAP2K4 21876842 2234358 Positive_regulation EPHB2 MAP2K4 22077956 3091385 Positive_regulation EPHB2 MAP2K4 22087839 681971 Positive_regulation EPHB2 MAP2K4 22087839 681979 Positive_regulation EPHB2 MAP2K4 22087839 682006 Positive_regulation EPHB2 MAP2K4 22091401 1831043 Positive_regulation EPHB2 MAP2K4 22159586 600519 Positive_regulation EPHB2 MAP2K4 22187659 1079060 Positive_regulation EPHB2 MAP2K4 22448169 3075837 Positive_regulation EPHB2 MAP2K4 22577355 2296712 Positive_regulation EPHB2 MAP2K4 22745804 2656649 Positive_regulation EPHB2 MAP2K4 22783258 902307 Positive_regulation EPHB2 MAP2K4 22870983 288878 Positive_regulation EPHB2 MAP2K4 22880048 2673699 Positive_regulation EPHB2 MAP2K4 23009336 1866995 Positive_regulation EPHB2 MAP2K4 23060802 959292 Positive_regulation EPHB2 MAP2K4 23060802 959408 Positive_regulation EPHB2 MAP2K4 23237773 2182003 Positive_regulation EPHB2 MAP2K4 23434660 1101907 Positive_regulation EPHB2 MAP2K4 23453810 1878025 Positive_regulation EPHB2 MAP2K4 23658559 883843 Positive_regulation EPHB2 MAP2K4 23675062 1064486 Positive_regulation EPHB2 MAP2K4 23704935 2796669 Positive_regulation EPHB2 MAP2K4 23704935 2796670 Positive_regulation EPHB2 MAP2K4 23762493 2804155 Positive_regulation EPHB2 MAP2K4 23782265 151704 Positive_regulation EPHB2 MAP2K4 23976985 2837982 Positive_regulation EPHB2 MAP2K4 24086653 2855432 Positive_regulation EPHB2 MAP2K4 24223225 2876734 Positive_regulation EPHB2 MAP2K4 24416349 2907644 Positive_regulation EPHB2 MAP2K4 24550252 752942 Positive_regulation EPHB2 MAP2K4 24550252 752956 Positive_regulation EPHB2 MAP2K4 24550835 963555 Positive_regulation EPHB2 MAP2K4 24608898 2932852 Positive_regulation EPHB2 MAP2K4 24710474 618058 Positive_regulation EPHB2 MAP2K4 24823877 1126536 Positive_regulation EPHB2 MAP2K4 24849047 1942131 Positive_regulation EPHB2 MAP2K4 24937142 851311 Positive_regulation EPHB2 MAP2K4 24937142 851404 Positive_regulation EPHB2 MAP2K4 25126479 212370 Positive_regulation EPHB2 MAP2K4 25226519 3007912 Positive_regulation EPHB2 MAP2K4 25479605 3032501 Positive_regulation EPHB2 MAP2K4 8996240 1599785 Positive_regulation EPHB2 MAP2K5 10477763 1249257 Positive_regulation EPHB2 MAP2K5 10477763 1249340 Positive_regulation EPHB2 MAP2K5 10648571 1255605 Positive_regulation EPHB2 MAP2K5 10648571 1255637 Positive_regulation EPHB2 MAP2K5 11309409 1269491 Positive_regulation EPHB2 MAP2K5 11435472 1519543 Positive_regulation EPHB2 MAP2K5 11435472 1519624 Positive_regulation EPHB2 MAP2K5 12370087 225134 Positive_regulation EPHB2 MAP2K5 14744999 1305412 Positive_regulation EPHB2 MAP2K5 14981092 1306416 Positive_regulation EPHB2 MAP2K5 15123736 1308386 Positive_regulation EPHB2 MAP2K5 15699069 1534486 Positive_regulation EPHB2 MAP2K5 16278666 426782 Positive_regulation EPHB2 MAP2K5 16365168 1326407 Positive_regulation EPHB2 MAP2K5 16787538 3096296 Positive_regulation EPHB2 MAP2K5 17631690 1896889 Positive_regulation EPHB2 MAP2K5 18159242 2381541 Positive_regulation EPHB2 MAP2K5 18332218 1349914 Positive_regulation EPHB2 MAP2K5 18335053 2386980 Positive_regulation EPHB2 MAP2K5 18404483 3087911 Positive_regulation EPHB2 MAP2K5 18404483 3088077 Positive_regulation EPHB2 MAP2K5 19018286 2400987 Positive_regulation EPHB2 MAP2K5 19383130 525244 Positive_regulation EPHB2 MAP2K5 19390590 2415323 Positive_regulation EPHB2 MAP2K5 19707375 175659 Positive_regulation EPHB2 MAP2K5 19878579 283636 Positive_regulation EPHB2 MAP2K5 20403177 659558 Positive_regulation EPHB2 MAP2K5 20462959 1776139 Positive_regulation EPHB2 MAP2K5 20818427 2136133 Positive_regulation EPHB2 MAP2K5 20819940 1379036 Positive_regulation EPHB2 MAP2K5 20868520 1859533 Positive_regulation EPHB2 MAP2K5 21278786 2137751 Positive_regulation EPHB2 MAP2K5 21386996 2506128 Positive_regulation EPHB2 MAP2K5 21505228 2175894 Positive_regulation EPHB2 MAP2K5 21505228 2175908 Positive_regulation EPHB2 MAP2K5 21505228 2175916 Positive_regulation EPHB2 MAP2K5 21505228 2175933 Positive_regulation EPHB2 MAP2K5 21559502 2520076 Positive_regulation EPHB2 MAP2K5 21642949 12880 Positive_regulation EPHB2 MAP2K5 21837281 2001963 Positive_regulation EPHB2 MAP2K5 21860067 2176435 Positive_regulation EPHB2 MAP2K5 21876842 2234359 Positive_regulation EPHB2 MAP2K5 22077956 3091386 Positive_regulation EPHB2 MAP2K5 22087839 681972 Positive_regulation EPHB2 MAP2K5 22087839 681980 Positive_regulation EPHB2 MAP2K5 22087839 682007 Positive_regulation EPHB2 MAP2K5 22091401 1831044 Positive_regulation EPHB2 MAP2K5 22159586 600520 Positive_regulation EPHB2 MAP2K5 22187659 1079061 Positive_regulation EPHB2 MAP2K5 22448169 3075838 Positive_regulation EPHB2 MAP2K5 22577355 2296713 Positive_regulation EPHB2 MAP2K5 22745804 2656650 Positive_regulation EPHB2 MAP2K5 22783258 902308 Positive_regulation EPHB2 MAP2K5 22870983 288879 Positive_regulation EPHB2 MAP2K5 22880048 2673700 Positive_regulation EPHB2 MAP2K5 23009336 1866996 Positive_regulation EPHB2 MAP2K5 23060802 959293 Positive_regulation EPHB2 MAP2K5 23060802 959409 Positive_regulation EPHB2 MAP2K5 23237773 2182004 Positive_regulation EPHB2 MAP2K5 23434660 1101908 Positive_regulation EPHB2 MAP2K5 23453810 1878026 Positive_regulation EPHB2 MAP2K5 23658559 883844 Positive_regulation EPHB2 MAP2K5 23675062 1064487 Positive_regulation EPHB2 MAP2K5 23704935 2796671 Positive_regulation EPHB2 MAP2K5 23704935 2796672 Positive_regulation EPHB2 MAP2K5 23762493 2804156 Positive_regulation EPHB2 MAP2K5 23782265 151705 Positive_regulation EPHB2 MAP2K5 23976985 2837983 Positive_regulation EPHB2 MAP2K5 24086653 2855433 Positive_regulation EPHB2 MAP2K5 24223225 2876735 Positive_regulation EPHB2 MAP2K5 24416349 2907645 Positive_regulation EPHB2 MAP2K5 24550252 752943 Positive_regulation EPHB2 MAP2K5 24550252 752957 Positive_regulation EPHB2 MAP2K5 24550835 963556 Positive_regulation EPHB2 MAP2K5 24608898 2932853 Positive_regulation EPHB2 MAP2K5 24710474 618059 Positive_regulation EPHB2 MAP2K5 24823877 1126537 Positive_regulation EPHB2 MAP2K5 24849047 1942132 Positive_regulation EPHB2 MAP2K5 24937142 851312 Positive_regulation EPHB2 MAP2K5 24937142 851405 Positive_regulation EPHB2 MAP2K5 25126479 212371 Positive_regulation EPHB2 MAP2K5 25226519 3007913 Positive_regulation EPHB2 MAP2K5 25479605 3032502 Positive_regulation EPHB2 MAP2K5 8996240 1599786 Positive_regulation EPHB2 MAP2K6 10330402 1246194 Positive_regulation EPHB2 MAP2K6 10477763 1249258 Positive_regulation EPHB2 MAP2K6 10477763 1249341 Positive_regulation EPHB2 MAP2K6 10648571 1255606 Positive_regulation EPHB2 MAP2K6 10648571 1255638 Positive_regulation EPHB2 MAP2K6 11309409 1269492 Positive_regulation EPHB2 MAP2K6 11435472 1519544 Positive_regulation EPHB2 MAP2K6 11435472 1519625 Positive_regulation EPHB2 MAP2K6 12370087 225135 Positive_regulation EPHB2 MAP2K6 14744999 1305413 Positive_regulation EPHB2 MAP2K6 14981092 1306417 Positive_regulation EPHB2 MAP2K6 15123736 1308387 Positive_regulation EPHB2 MAP2K6 15699069 1534487 Positive_regulation EPHB2 MAP2K6 16278666 426783 Positive_regulation EPHB2 MAP2K6 16365168 1326408 Positive_regulation EPHB2 MAP2K6 16787538 3096297 Positive_regulation EPHB2 MAP2K6 17631690 1896890 Positive_regulation EPHB2 MAP2K6 18159242 2381542 Positive_regulation EPHB2 MAP2K6 18332218 1349915 Positive_regulation EPHB2 MAP2K6 18335053 2386981 Positive_regulation EPHB2 MAP2K6 18404483 3087912 Positive_regulation EPHB2 MAP2K6 18404483 3088078 Positive_regulation EPHB2 MAP2K6 19018286 2400988 Positive_regulation EPHB2 MAP2K6 19383130 525245 Positive_regulation EPHB2 MAP2K6 19390590 2415324 Positive_regulation EPHB2 MAP2K6 19707375 175660 Positive_regulation EPHB2 MAP2K6 19878579 283637 Positive_regulation EPHB2 MAP2K6 20403177 659559 Positive_regulation EPHB2 MAP2K6 20462959 1776140 Positive_regulation EPHB2 MAP2K6 20818427 2136134 Positive_regulation EPHB2 MAP2K6 20819940 1379037 Positive_regulation EPHB2 MAP2K6 20868520 1859534 Positive_regulation EPHB2 MAP2K6 21278786 2137752 Positive_regulation EPHB2 MAP2K6 21386996 2506129 Positive_regulation EPHB2 MAP2K6 21505228 2175895 Positive_regulation EPHB2 MAP2K6 21505228 2175909 Positive_regulation EPHB2 MAP2K6 21505228 2175917 Positive_regulation EPHB2 MAP2K6 21505228 2175934 Positive_regulation EPHB2 MAP2K6 21559502 2520077 Positive_regulation EPHB2 MAP2K6 21642949 12881 Positive_regulation EPHB2 MAP2K6 21837281 2001964 Positive_regulation EPHB2 MAP2K6 21860067 2176436 Positive_regulation EPHB2 MAP2K6 21876842 2234360 Positive_regulation EPHB2 MAP2K6 22077956 3091387 Positive_regulation EPHB2 MAP2K6 22087839 681973 Positive_regulation EPHB2 MAP2K6 22087839 681981 Positive_regulation EPHB2 MAP2K6 22087839 682008 Positive_regulation EPHB2 MAP2K6 22091401 1831045 Positive_regulation EPHB2 MAP2K6 22159586 600521 Positive_regulation EPHB2 MAP2K6 22187659 1079062 Positive_regulation EPHB2 MAP2K6 22448169 3075839 Positive_regulation EPHB2 MAP2K6 22577355 2296714 Positive_regulation EPHB2 MAP2K6 22745804 2656651 Positive_regulation EPHB2 MAP2K6 22783258 902309 Positive_regulation EPHB2 MAP2K6 22870983 288880 Positive_regulation EPHB2 MAP2K6 22880048 2673701 Positive_regulation EPHB2 MAP2K6 23009336 1866997 Positive_regulation EPHB2 MAP2K6 23060802 959294 Positive_regulation EPHB2 MAP2K6 23060802 959410 Positive_regulation EPHB2 MAP2K6 23237773 2182005 Positive_regulation EPHB2 MAP2K6 23434660 1101909 Positive_regulation EPHB2 MAP2K6 23453810 1878027 Positive_regulation EPHB2 MAP2K6 23658559 883845 Positive_regulation EPHB2 MAP2K6 23675062 1064488 Positive_regulation EPHB2 MAP2K6 23704935 2796673 Positive_regulation EPHB2 MAP2K6 23704935 2796674 Positive_regulation EPHB2 MAP2K6 23762493 2804157 Positive_regulation EPHB2 MAP2K6 23782265 151706 Positive_regulation EPHB2 MAP2K6 23976985 2837984 Positive_regulation EPHB2 MAP2K6 24086653 2855434 Positive_regulation EPHB2 MAP2K6 24223225 2876736 Positive_regulation EPHB2 MAP2K6 24416349 2907646 Positive_regulation EPHB2 MAP2K6 24550252 752944 Positive_regulation EPHB2 MAP2K6 24550252 752958 Positive_regulation EPHB2 MAP2K6 24550835 963557 Positive_regulation EPHB2 MAP2K6 24608898 2932854 Positive_regulation EPHB2 MAP2K6 24710474 618060 Positive_regulation EPHB2 MAP2K6 24823877 1126538 Positive_regulation EPHB2 MAP2K6 24849047 1942133 Positive_regulation EPHB2 MAP2K6 24937142 851313 Positive_regulation EPHB2 MAP2K6 24937142 851406 Positive_regulation EPHB2 MAP2K6 25126479 212372 Positive_regulation EPHB2 MAP2K6 25226519 3007914 Positive_regulation EPHB2 MAP2K6 25479605 3032503 Positive_regulation EPHB2 MAP2K6 8996240 1599787 Positive_regulation EPHB2 MAP2K7 10477763 1249259 Positive_regulation EPHB2 MAP2K7 10477763 1249342 Positive_regulation EPHB2 MAP2K7 10648571 1255607 Positive_regulation EPHB2 MAP2K7 10648571 1255639 Positive_regulation EPHB2 MAP2K7 11309409 1269493 Positive_regulation EPHB2 MAP2K7 11435472 1519545 Positive_regulation EPHB2 MAP2K7 11435472 1519626 Positive_regulation EPHB2 MAP2K7 12370087 225136 Positive_regulation EPHB2 MAP2K7 14744999 1305414 Positive_regulation EPHB2 MAP2K7 14981092 1306418 Positive_regulation EPHB2 MAP2K7 15123736 1308388 Positive_regulation EPHB2 MAP2K7 15699069 1534488 Positive_regulation EPHB2 MAP2K7 16278666 426784 Positive_regulation EPHB2 MAP2K7 16365168 1326409 Positive_regulation EPHB2 MAP2K7 16787538 3096298 Positive_regulation EPHB2 MAP2K7 17631690 1896891 Positive_regulation EPHB2 MAP2K7 18159242 2381543 Positive_regulation EPHB2 MAP2K7 18332218 1349916 Positive_regulation EPHB2 MAP2K7 18335053 2386982 Positive_regulation EPHB2 MAP2K7 18404483 3087913 Positive_regulation EPHB2 MAP2K7 18404483 3088079 Positive_regulation EPHB2 MAP2K7 19018286 2400989 Positive_regulation EPHB2 MAP2K7 19383130 525246 Positive_regulation EPHB2 MAP2K7 19390590 2415325 Positive_regulation EPHB2 MAP2K7 19707375 175661 Positive_regulation EPHB2 MAP2K7 19878579 283638 Positive_regulation EPHB2 MAP2K7 20403177 659560 Positive_regulation EPHB2 MAP2K7 20462959 1776141 Positive_regulation EPHB2 MAP2K7 20818427 2136135 Positive_regulation EPHB2 MAP2K7 20819940 1379038 Positive_regulation EPHB2 MAP2K7 20868520 1859535 Positive_regulation EPHB2 MAP2K7 21278786 2137753 Positive_regulation EPHB2 MAP2K7 21386996 2506130 Positive_regulation EPHB2 MAP2K7 21505228 2175896 Positive_regulation EPHB2 MAP2K7 21505228 2175910 Positive_regulation EPHB2 MAP2K7 21505228 2175918 Positive_regulation EPHB2 MAP2K7 21505228 2175935 Positive_regulation EPHB2 MAP2K7 21559502 2520078 Positive_regulation EPHB2 MAP2K7 21642949 12882 Positive_regulation EPHB2 MAP2K7 21837281 2001965 Positive_regulation EPHB2 MAP2K7 21860067 2176437 Positive_regulation EPHB2 MAP2K7 21876842 2234361 Positive_regulation EPHB2 MAP2K7 22077956 3091388 Positive_regulation EPHB2 MAP2K7 22087839 681974 Positive_regulation EPHB2 MAP2K7 22087839 681982 Positive_regulation EPHB2 MAP2K7 22087839 682009 Positive_regulation EPHB2 MAP2K7 22091401 1831046 Positive_regulation EPHB2 MAP2K7 22159586 600522 Positive_regulation EPHB2 MAP2K7 22187659 1079063 Positive_regulation EPHB2 MAP2K7 22448169 3075840 Positive_regulation EPHB2 MAP2K7 22577355 2296715 Positive_regulation EPHB2 MAP2K7 22745804 2656652 Positive_regulation EPHB2 MAP2K7 22783258 902310 Positive_regulation EPHB2 MAP2K7 22870983 288881 Positive_regulation EPHB2 MAP2K7 22880048 2673702 Positive_regulation EPHB2 MAP2K7 23009336 1866998 Positive_regulation EPHB2 MAP2K7 23060802 959295 Positive_regulation EPHB2 MAP2K7 23060802 959411 Positive_regulation EPHB2 MAP2K7 23237773 2182006 Positive_regulation EPHB2 MAP2K7 23434660 1101910 Positive_regulation EPHB2 MAP2K7 23453810 1878028 Positive_regulation EPHB2 MAP2K7 23658559 883846 Positive_regulation EPHB2 MAP2K7 23675062 1064489 Positive_regulation EPHB2 MAP2K7 23704935 2796675 Positive_regulation EPHB2 MAP2K7 23704935 2796676 Positive_regulation EPHB2 MAP2K7 23762493 2804158 Positive_regulation EPHB2 MAP2K7 23782265 151707 Positive_regulation EPHB2 MAP2K7 23976985 2837985 Positive_regulation EPHB2 MAP2K7 24086653 2855435 Positive_regulation EPHB2 MAP2K7 24223225 2876737 Positive_regulation EPHB2 MAP2K7 24416349 2907647 Positive_regulation EPHB2 MAP2K7 24550252 752945 Positive_regulation EPHB2 MAP2K7 24550252 752959 Positive_regulation EPHB2 MAP2K7 24550835 963558 Positive_regulation EPHB2 MAP2K7 24608898 2932855 Positive_regulation EPHB2 MAP2K7 24710474 618061 Positive_regulation EPHB2 MAP2K7 24823877 1126539 Positive_regulation EPHB2 MAP2K7 24849047 1942134 Positive_regulation EPHB2 MAP2K7 24937142 851314 Positive_regulation EPHB2 MAP2K7 24937142 851407 Positive_regulation EPHB2 MAP2K7 25126479 212373 Positive_regulation EPHB2 MAP2K7 25161081 1498017 Positive_regulation EPHB2 MAP2K7 25226519 3007915 Positive_regulation EPHB2 MAP2K7 25479605 3032504 Positive_regulation EPHB2 MAP2K7 8996240 1599788 Positive_regulation EPHB2 MAP3K1 11352944 1270206 Positive_regulation EPHB2 MAP3K1 18420486 705497 Positive_regulation EPHB2 MAP3K1 22200028 2115801 Positive_regulation EPHB2 MAP3K10 22200028 2115802 Positive_regulation EPHB2 MAP3K11 22200028 2115803 Positive_regulation EPHB2 MAP3K11 23902710 2183915 Positive_regulation EPHB2 MAP3K12 22200028 2115804 Positive_regulation EPHB2 MAP3K13 22200028 2115805 Positive_regulation EPHB2 MAP3K13 23552557 2155966 Positive_regulation EPHB2 MAP3K13 23552557 2155967 Positive_regulation EPHB2 MAP3K14 22200028 2115806 Positive_regulation EPHB2 MAP3K15 22200028 2115800 Positive_regulation EPHB2 MAP3K19 22200028 2115799 Positive_regulation EPHB2 MAP3K2 22200028 2115807 Positive_regulation EPHB2 MAP3K3 22200028 2115808 Positive_regulation EPHB2 MAP3K3 24206648 367426 Positive_regulation EPHB2 MAP3K3 24957684 2232010 Positive_regulation EPHB2 MAP3K3 24957684 2232029 Positive_regulation EPHB2 MAP3K4 22200028 2115809 Positive_regulation EPHB2 MAP3K5 17389227 1338446 Positive_regulation EPHB2 MAP3K5 22197930 1951088 Positive_regulation EPHB2 MAP3K5 22200028 2115810 Positive_regulation EPHB2 MAP3K5 23696862 2795613 Positive_regulation EPHB2 MAP3K5 23696862 2795614 Positive_regulation EPHB2 MAP3K5 24849047 1942135 Positive_regulation EPHB2 MAP3K6 22200028 2115811 Positive_regulation EPHB2 MAP3K6 24957684 2232011 Positive_regulation EPHB2 MAP3K6 24957684 2232030 Positive_regulation EPHB2 MAP3K7 22200028 2115812 Positive_regulation EPHB2 MAP3K7 24550720 2300536 Positive_regulation EPHB2 MAP3K7 24801688 2961670 Positive_regulation EPHB2 MAP3K7 PMC2756345 495869 Positive_regulation EPHB2 MAP3K8 15575964 1844358 Positive_regulation EPHB2 MAP3K8 15699069 1534489 Positive_regulation EPHB2 MAP3K8 17935622 352067 Positive_regulation EPHB2 MAP3K8 19667062 1555560 Positive_regulation EPHB2 MAP3K8 19667062 1555561 Positive_regulation EPHB2 MAP3K8 19667062 1555562 Positive_regulation EPHB2 MAP3K8 19667062 1555563 Positive_regulation EPHB2 MAP3K8 19667062 1555674 Positive_regulation EPHB2 MAP3K8 19808894 711202 Positive_regulation EPHB2 MAP3K8 21107320 1986760 Positive_regulation EPHB2 MAP3K8 21267413 2495402 Positive_regulation EPHB2 MAP3K8 21346175 717988 Positive_regulation EPHB2 MAP3K8 21346175 718015 Positive_regulation EPHB2 MAP3K8 22200028 2115813 Positive_regulation EPHB2 MAP3K8 23557442 151363 Positive_regulation EPHB2 MAP3K8 24642963 2935456 Positive_regulation EPHB2 MAP3K8 25344914 2206026 Positive_regulation EPHB2 MAP3K9 22197930 1951089 Positive_regulation EPHB2 MAP3K9 22200028 2115814 Positive_regulation EPHB2 MAPK1 18578886 356852 Positive_regulation EPHB2 MAPK1 19047466 1361945 Positive_regulation EPHB2 MAPK1 19047466 1362081 Positive_regulation EPHB2 MAPK1 19047466 1362120 Positive_regulation EPHB2 MAPK1 19161638 252243 Positive_regulation EPHB2 MAPK1 19859561 2429727 Positive_regulation EPHB2 MAPK1 20819940 1379039 Positive_regulation EPHB2 MAPK1 20827342 2114709 Positive_regulation EPHB2 MAPK1 20827342 2114710 Positive_regulation EPHB2 MAPK1 21488184 3232768 Positive_regulation EPHB2 MAPK1 21559368 2518952 Positive_regulation EPHB2 MAPK1 21752268 260487 Positive_regulation EPHB2 MAPK1 21876711 813169 Positive_regulation EPHB2 MAPK1 22294469 135319 Positive_regulation EPHB2 MAPK1 22507553 1661680 Positive_regulation EPHB2 MAPK1 22675451 2648313 Positive_regulation EPHB2 MAPK1 23292489 1886117 Positive_regulation EPHB2 MAPK1 23613754 2782099 Positive_regulation EPHB2 MAPK1 23755370 945373 Positive_regulation EPHB2 MAPK1 23762493 2804203 Positive_regulation EPHB2 MAPK1 23951028 2833291 Positive_regulation EPHB2 MAPK1 24058556 2847998 Positive_regulation EPHB2 MAPK1 24098984 1726327 Positive_regulation EPHB2 MAPK1 24421891 2909279 Positive_regulation EPHB2 MAPK1 24741325 487706 Positive_regulation EPHB2 MAPK1 24862327 680599 Positive_regulation EPHB2 MAPK1 25258648 1240879 Positive_regulation EPHB2 MAPK1 25268615 1131266 Positive_regulation EPHB2 MAPK1 25299961 174457 Positive_regulation EPHB2 MAPK10 18578886 356853 Positive_regulation EPHB2 MAPK10 19047466 1361946 Positive_regulation EPHB2 MAPK10 19047466 1362082 Positive_regulation EPHB2 MAPK10 19047466 1362121 Positive_regulation EPHB2 MAPK10 19161638 252244 Positive_regulation EPHB2 MAPK10 19859561 2429728 Positive_regulation EPHB2 MAPK10 20819940 1379040 Positive_regulation EPHB2 MAPK10 20827342 2114711 Positive_regulation EPHB2 MAPK10 20827342 2114712 Positive_regulation EPHB2 MAPK10 21488184 3232769 Positive_regulation EPHB2 MAPK10 21559368 2518953 Positive_regulation EPHB2 MAPK10 21752268 260488 Positive_regulation EPHB2 MAPK10 21876711 813170 Positive_regulation EPHB2 MAPK10 22294469 135320 Positive_regulation EPHB2 MAPK10 22507553 1661681 Positive_regulation EPHB2 MAPK10 22675451 2648314 Positive_regulation EPHB2 MAPK10 23292489 1886118 Positive_regulation EPHB2 MAPK10 23755370 945374 Positive_regulation EPHB2 MAPK10 23762493 2804204 Positive_regulation EPHB2 MAPK10 23951028 2833292 Positive_regulation EPHB2 MAPK10 24058556 2847999 Positive_regulation EPHB2 MAPK10 24098984 1726328 Positive_regulation EPHB2 MAPK10 24421891 2909280 Positive_regulation EPHB2 MAPK10 24741325 487707 Positive_regulation EPHB2 MAPK10 24862327 680600 Positive_regulation EPHB2 MAPK10 25258648 1240880 Positive_regulation EPHB2 MAPK10 25268615 1131267 Positive_regulation EPHB2 MAPK10 25299961 174458 Positive_regulation EPHB2 MAPK11 18578886 356854 Positive_regulation EPHB2 MAPK11 19047466 1361947 Positive_regulation EPHB2 MAPK11 19047466 1362083 Positive_regulation EPHB2 MAPK11 19047466 1362122 Positive_regulation EPHB2 MAPK11 19161638 252245 Positive_regulation EPHB2 MAPK11 19859561 2429729 Positive_regulation EPHB2 MAPK11 20819940 1379041 Positive_regulation EPHB2 MAPK11 20827342 2114713 Positive_regulation EPHB2 MAPK11 20827342 2114714 Positive_regulation EPHB2 MAPK11 21488184 3232770 Positive_regulation EPHB2 MAPK11 21559368 2518954 Positive_regulation EPHB2 MAPK11 21752268 260489 Positive_regulation EPHB2 MAPK11 21876711 813171 Positive_regulation EPHB2 MAPK11 22294469 135321 Positive_regulation EPHB2 MAPK11 22507553 1661682 Positive_regulation EPHB2 MAPK11 22675451 2648315 Positive_regulation EPHB2 MAPK11 23292489 1886119 Positive_regulation EPHB2 MAPK11 23755370 945375 Positive_regulation EPHB2 MAPK11 23762493 2804205 Positive_regulation EPHB2 MAPK11 23951028 2833293 Positive_regulation EPHB2 MAPK11 24058556 2848000 Positive_regulation EPHB2 MAPK11 24098984 1726329 Positive_regulation EPHB2 MAPK11 24421891 2909281 Positive_regulation EPHB2 MAPK11 24741325 487708 Positive_regulation EPHB2 MAPK11 24862327 680601 Positive_regulation EPHB2 MAPK11 25258648 1240881 Positive_regulation EPHB2 MAPK11 25268615 1131268 Positive_regulation EPHB2 MAPK11 25299961 174459 Positive_regulation EPHB2 MAPK12 18578886 356855 Positive_regulation EPHB2 MAPK12 19047466 1361948 Positive_regulation EPHB2 MAPK12 19047466 1362084 Positive_regulation EPHB2 MAPK12 19047466 1362123 Positive_regulation EPHB2 MAPK12 19161638 252246 Positive_regulation EPHB2 MAPK12 19859561 2429730 Positive_regulation EPHB2 MAPK12 20819940 1379042 Positive_regulation EPHB2 MAPK12 20827342 2114715 Positive_regulation EPHB2 MAPK12 20827342 2114716 Positive_regulation EPHB2 MAPK12 21488184 3232771 Positive_regulation EPHB2 MAPK12 21559368 2518955 Positive_regulation EPHB2 MAPK12 21752268 260490 Positive_regulation EPHB2 MAPK12 21876711 813172 Positive_regulation EPHB2 MAPK12 22294469 135322 Positive_regulation EPHB2 MAPK12 22507553 1661683 Positive_regulation EPHB2 MAPK12 22675451 2648316 Positive_regulation EPHB2 MAPK12 23292489 1886120 Positive_regulation EPHB2 MAPK12 23755370 945376 Positive_regulation EPHB2 MAPK12 23762493 2804206 Positive_regulation EPHB2 MAPK12 23951028 2833294 Positive_regulation EPHB2 MAPK12 24058556 2848001 Positive_regulation EPHB2 MAPK12 24098984 1726330 Positive_regulation EPHB2 MAPK12 24421891 2909282 Positive_regulation EPHB2 MAPK12 24741325 487709 Positive_regulation EPHB2 MAPK12 24862327 680602 Positive_regulation EPHB2 MAPK12 25258648 1240882 Positive_regulation EPHB2 MAPK12 25268615 1131269 Positive_regulation EPHB2 MAPK12 25299961 174460 Positive_regulation EPHB2 MAPK13 18578886 356856 Positive_regulation EPHB2 MAPK13 19047466 1361949 Positive_regulation EPHB2 MAPK13 19047466 1362085 Positive_regulation EPHB2 MAPK13 19047466 1362124 Positive_regulation EPHB2 MAPK13 19161638 252247 Positive_regulation EPHB2 MAPK13 19859561 2429731 Positive_regulation EPHB2 MAPK13 20819940 1379043 Positive_regulation EPHB2 MAPK13 20827342 2114717 Positive_regulation EPHB2 MAPK13 20827342 2114718 Positive_regulation EPHB2 MAPK13 21488184 3232772 Positive_regulation EPHB2 MAPK13 21559368 2518956 Positive_regulation EPHB2 MAPK13 21752268 260491 Positive_regulation EPHB2 MAPK13 21876711 813173 Positive_regulation EPHB2 MAPK13 22294469 135323 Positive_regulation EPHB2 MAPK13 22507553 1661684 Positive_regulation EPHB2 MAPK13 22675451 2648317 Positive_regulation EPHB2 MAPK13 23292489 1886121 Positive_regulation EPHB2 MAPK13 23755370 945377 Positive_regulation EPHB2 MAPK13 23762493 2804207 Positive_regulation EPHB2 MAPK13 23951028 2833295 Positive_regulation EPHB2 MAPK13 24058556 2848002 Positive_regulation EPHB2 MAPK13 24098984 1726331 Positive_regulation EPHB2 MAPK13 24421891 2909283 Positive_regulation EPHB2 MAPK13 24741325 487710 Positive_regulation EPHB2 MAPK13 24862327 680603 Positive_regulation EPHB2 MAPK13 25258648 1240883 Positive_regulation EPHB2 MAPK13 25268615 1131270 Positive_regulation EPHB2 MAPK13 25299961 174461 Positive_regulation EPHB2 MAPK14 18578886 356857 Positive_regulation EPHB2 MAPK14 19047466 1361950 Positive_regulation EPHB2 MAPK14 19047466 1362086 Positive_regulation EPHB2 MAPK14 19047466 1362125 Positive_regulation EPHB2 MAPK14 19161638 252248 Positive_regulation EPHB2 MAPK14 19859561 2429732 Positive_regulation EPHB2 MAPK14 20819940 1379044 Positive_regulation EPHB2 MAPK14 20827342 2114719 Positive_regulation EPHB2 MAPK14 20827342 2114720 Positive_regulation EPHB2 MAPK14 21488184 3232773 Positive_regulation EPHB2 MAPK14 21559368 2518957 Positive_regulation EPHB2 MAPK14 21752268 260492 Positive_regulation EPHB2 MAPK14 21876711 813174 Positive_regulation EPHB2 MAPK14 22294469 135324 Positive_regulation EPHB2 MAPK14 22507553 1661685 Positive_regulation EPHB2 MAPK14 22675451 2648318 Positive_regulation EPHB2 MAPK14 23292489 1886122 Positive_regulation EPHB2 MAPK14 23755370 945378 Positive_regulation EPHB2 MAPK14 23762493 2804208 Positive_regulation EPHB2 MAPK14 23951028 2833296 Positive_regulation EPHB2 MAPK14 24058556 2848003 Positive_regulation EPHB2 MAPK14 24098984 1726332 Positive_regulation EPHB2 MAPK14 24421891 2909284 Positive_regulation EPHB2 MAPK14 24741325 487711 Positive_regulation EPHB2 MAPK14 24862327 680604 Positive_regulation EPHB2 MAPK14 25258648 1240884 Positive_regulation EPHB2 MAPK14 25268615 1131271 Positive_regulation EPHB2 MAPK14 25299961 174462 Positive_regulation EPHB2 MAPK15 18578886 356851 Positive_regulation EPHB2 MAPK15 19047466 1361939 Positive_regulation EPHB2 MAPK15 19047466 1362080 Positive_regulation EPHB2 MAPK15 19047466 1362119 Positive_regulation EPHB2 MAPK15 19161638 252242 Positive_regulation EPHB2 MAPK15 19859561 2429726 Positive_regulation EPHB2 MAPK15 20819940 1379031 Positive_regulation EPHB2 MAPK15 20827342 2114707 Positive_regulation EPHB2 MAPK15 20827342 2114708 Positive_regulation EPHB2 MAPK15 21488184 3232767 Positive_regulation EPHB2 MAPK15 21559368 2518948 Positive_regulation EPHB2 MAPK15 21752268 260486 Positive_regulation EPHB2 MAPK15 21876711 813168 Positive_regulation EPHB2 MAPK15 22294469 135318 Positive_regulation EPHB2 MAPK15 22507553 1661678 Positive_regulation EPHB2 MAPK15 22675451 2648312 Positive_regulation EPHB2 MAPK15 23292489 1886116 Positive_regulation EPHB2 MAPK15 23755370 945372 Positive_regulation EPHB2 MAPK15 23762493 2804202 Positive_regulation EPHB2 MAPK15 23951028 2833290 Positive_regulation EPHB2 MAPK15 24058556 2847996 Positive_regulation EPHB2 MAPK15 24098984 1726326 Positive_regulation EPHB2 MAPK15 24421891 2909278 Positive_regulation EPHB2 MAPK15 24741325 487705 Positive_regulation EPHB2 MAPK15 24862327 680598 Positive_regulation EPHB2 MAPK15 25258648 1240878 Positive_regulation EPHB2 MAPK15 25268615 1131262 Positive_regulation EPHB2 MAPK15 25299961 174456 Positive_regulation EPHB2 MAPK3 10725339 1256860 Positive_regulation EPHB2 MAPK3 18578886 356858 Positive_regulation EPHB2 MAPK3 19047466 1361951 Positive_regulation EPHB2 MAPK3 19047466 1362087 Positive_regulation EPHB2 MAPK3 19047466 1362126 Positive_regulation EPHB2 MAPK3 19161638 252249 Positive_regulation EPHB2 MAPK3 19859561 2429733 Positive_regulation EPHB2 MAPK3 20819940 1379045 Positive_regulation EPHB2 MAPK3 20827342 2114721 Positive_regulation EPHB2 MAPK3 20827342 2114722 Positive_regulation EPHB2 MAPK3 21488184 3232774 Positive_regulation EPHB2 MAPK3 21559368 2518958 Positive_regulation EPHB2 MAPK3 21752268 260493 Positive_regulation EPHB2 MAPK3 21876711 813175 Positive_regulation EPHB2 MAPK3 21876715 813257 Positive_regulation EPHB2 MAPK3 22174878 2582404 Positive_regulation EPHB2 MAPK3 22294469 135325 Positive_regulation EPHB2 MAPK3 22507553 1661686 Positive_regulation EPHB2 MAPK3 22675451 2648319 Positive_regulation EPHB2 MAPK3 22966240 636917 Positive_regulation EPHB2 MAPK3 23133759 1079514 Positive_regulation EPHB2 MAPK3 23292489 1886123 Positive_regulation EPHB2 MAPK3 23755370 945379 Positive_regulation EPHB2 MAPK3 23762493 2804209 Positive_regulation EPHB2 MAPK3 23951028 2833297 Positive_regulation EPHB2 MAPK3 24058556 2848004 Positive_regulation EPHB2 MAPK3 24098984 1726333 Positive_regulation EPHB2 MAPK3 24421891 2909285 Positive_regulation EPHB2 MAPK3 24710481 618600 Positive_regulation EPHB2 MAPK3 24741325 487712 Positive_regulation EPHB2 MAPK3 24862327 680605 Positive_regulation EPHB2 MAPK3 25258648 1240885 Positive_regulation EPHB2 MAPK3 25268615 1131272 Positive_regulation EPHB2 MAPK3 25299961 174463 Positive_regulation EPHB2 MAPK3 25496490 3115150 Positive_regulation EPHB2 MAPK4 18578886 356859 Positive_regulation EPHB2 MAPK4 19047466 1361952 Positive_regulation EPHB2 MAPK4 19047466 1362088 Positive_regulation EPHB2 MAPK4 19047466 1362127 Positive_regulation EPHB2 MAPK4 19161638 252250 Positive_regulation EPHB2 MAPK4 19859561 2429734 Positive_regulation EPHB2 MAPK4 20819940 1379046 Positive_regulation EPHB2 MAPK4 20827342 2114723 Positive_regulation EPHB2 MAPK4 20827342 2114724 Positive_regulation EPHB2 MAPK4 21488184 3232775 Positive_regulation EPHB2 MAPK4 21559368 2518959 Positive_regulation EPHB2 MAPK4 21752268 260494 Positive_regulation EPHB2 MAPK4 21876711 813176 Positive_regulation EPHB2 MAPK4 22294469 135326 Positive_regulation EPHB2 MAPK4 22507553 1661687 Positive_regulation EPHB2 MAPK4 22675451 2648320 Positive_regulation EPHB2 MAPK4 23292489 1886124 Positive_regulation EPHB2 MAPK4 23755370 945380 Positive_regulation EPHB2 MAPK4 23762493 2804210 Positive_regulation EPHB2 MAPK4 23951028 2833298 Positive_regulation EPHB2 MAPK4 24058556 2848005 Positive_regulation EPHB2 MAPK4 24098984 1726334 Positive_regulation EPHB2 MAPK4 24421891 2909286 Positive_regulation EPHB2 MAPK4 24741325 487713 Positive_regulation EPHB2 MAPK4 24862327 680606 Positive_regulation EPHB2 MAPK4 25258648 1240886 Positive_regulation EPHB2 MAPK4 25268615 1131273 Positive_regulation EPHB2 MAPK4 25299961 174464 Positive_regulation EPHB2 MAPK6 18578886 356860 Positive_regulation EPHB2 MAPK6 19047466 1361953 Positive_regulation EPHB2 MAPK6 19047466 1362089 Positive_regulation EPHB2 MAPK6 19047466 1362128 Positive_regulation EPHB2 MAPK6 19161638 252251 Positive_regulation EPHB2 MAPK6 19859561 2429735 Positive_regulation EPHB2 MAPK6 20819940 1379047 Positive_regulation EPHB2 MAPK6 20827342 2114725 Positive_regulation EPHB2 MAPK6 20827342 2114726 Positive_regulation EPHB2 MAPK6 21488184 3232776 Positive_regulation EPHB2 MAPK6 21559368 2518960 Positive_regulation EPHB2 MAPK6 21752268 260495 Positive_regulation EPHB2 MAPK6 21876711 813177 Positive_regulation EPHB2 MAPK6 22294469 135327 Positive_regulation EPHB2 MAPK6 22507553 1661688 Positive_regulation EPHB2 MAPK6 22675451 2648321 Positive_regulation EPHB2 MAPK6 23292489 1886125 Positive_regulation EPHB2 MAPK6 23755370 945381 Positive_regulation EPHB2 MAPK6 23762493 2804211 Positive_regulation EPHB2 MAPK6 23951028 2833299 Positive_regulation EPHB2 MAPK6 24058556 2848006 Positive_regulation EPHB2 MAPK6 24098984 1726335 Positive_regulation EPHB2 MAPK6 24421891 2909287 Positive_regulation EPHB2 MAPK6 24741325 487714 Positive_regulation EPHB2 MAPK6 24862327 680607 Positive_regulation EPHB2 MAPK6 25258648 1240887 Positive_regulation EPHB2 MAPK6 25268615 1131274 Positive_regulation EPHB2 MAPK6 25299961 174465 Positive_regulation EPHB2 MAPK7 18578886 356861 Positive_regulation EPHB2 MAPK7 19047466 1361954 Positive_regulation EPHB2 MAPK7 19047466 1362090 Positive_regulation EPHB2 MAPK7 19047466 1362129 Positive_regulation EPHB2 MAPK7 19161638 252252 Positive_regulation EPHB2 MAPK7 19859561 2429736 Positive_regulation EPHB2 MAPK7 20819940 1379048 Positive_regulation EPHB2 MAPK7 20827342 2114727 Positive_regulation EPHB2 MAPK7 20827342 2114728 Positive_regulation EPHB2 MAPK7 21488184 3232777 Positive_regulation EPHB2 MAPK7 21559368 2518961 Positive_regulation EPHB2 MAPK7 21752268 260496 Positive_regulation EPHB2 MAPK7 21876711 813178 Positive_regulation EPHB2 MAPK7 22294469 135328 Positive_regulation EPHB2 MAPK7 22507553 1661689 Positive_regulation EPHB2 MAPK7 22675451 2648322 Positive_regulation EPHB2 MAPK7 23292489 1886126 Positive_regulation EPHB2 MAPK7 23755370 945382 Positive_regulation EPHB2 MAPK7 23762493 2804212 Positive_regulation EPHB2 MAPK7 23951028 2833300 Positive_regulation EPHB2 MAPK7 24058556 2848007 Positive_regulation EPHB2 MAPK7 24098984 1726336 Positive_regulation EPHB2 MAPK7 24421891 2909288 Positive_regulation EPHB2 MAPK7 24741325 487715 Positive_regulation EPHB2 MAPK7 24862327 680608 Positive_regulation EPHB2 MAPK7 25258648 1240888 Positive_regulation EPHB2 MAPK7 25268615 1131275 Positive_regulation EPHB2 MAPK7 25299961 174466 Positive_regulation EPHB2 MAPK8 18578886 356862 Positive_regulation EPHB2 MAPK8 19047466 1361955 Positive_regulation EPHB2 MAPK8 19047466 1362091 Positive_regulation EPHB2 MAPK8 19047466 1362130 Positive_regulation EPHB2 MAPK8 19161638 252253 Positive_regulation EPHB2 MAPK8 19859561 2429737 Positive_regulation EPHB2 MAPK8 20819940 1379049 Positive_regulation EPHB2 MAPK8 20827342 2114729 Positive_regulation EPHB2 MAPK8 20827342 2114730 Positive_regulation EPHB2 MAPK8 21488184 3232778 Positive_regulation EPHB2 MAPK8 21559368 2518962 Positive_regulation EPHB2 MAPK8 21752268 260497 Positive_regulation EPHB2 MAPK8 21876711 813179 Positive_regulation EPHB2 MAPK8 22294469 135329 Positive_regulation EPHB2 MAPK8 22507553 1661690 Positive_regulation EPHB2 MAPK8 22675451 2648323 Positive_regulation EPHB2 MAPK8 23292489 1886127 Positive_regulation EPHB2 MAPK8 23755370 945383 Positive_regulation EPHB2 MAPK8 23762493 2804213 Positive_regulation EPHB2 MAPK8 23951028 2833301 Positive_regulation EPHB2 MAPK8 24058556 2848008 Positive_regulation EPHB2 MAPK8 24098984 1726337 Positive_regulation EPHB2 MAPK8 24421891 2909289 Positive_regulation EPHB2 MAPK8 24741325 487716 Positive_regulation EPHB2 MAPK8 24862327 680609 Positive_regulation EPHB2 MAPK8 25258648 1240889 Positive_regulation EPHB2 MAPK8 25268615 1131276 Positive_regulation EPHB2 MAPK8 25299961 174467 Positive_regulation EPHB2 MAPK9 18578886 356863 Positive_regulation EPHB2 MAPK9 19047466 1361956 Positive_regulation EPHB2 MAPK9 19047466 1362092 Positive_regulation EPHB2 MAPK9 19047466 1362131 Positive_regulation EPHB2 MAPK9 19161638 252254 Positive_regulation EPHB2 MAPK9 19859561 2429738 Positive_regulation EPHB2 MAPK9 20819940 1379050 Positive_regulation EPHB2 MAPK9 20827342 2114731 Positive_regulation EPHB2 MAPK9 20827342 2114732 Positive_regulation EPHB2 MAPK9 21488184 3232779 Positive_regulation EPHB2 MAPK9 21559368 2518963 Positive_regulation EPHB2 MAPK9 21752268 260498 Positive_regulation EPHB2 MAPK9 21876711 813180 Positive_regulation EPHB2 MAPK9 22294469 135330 Positive_regulation EPHB2 MAPK9 22507553 1661691 Positive_regulation EPHB2 MAPK9 22675451 2648324 Positive_regulation EPHB2 MAPK9 23292489 1886128 Positive_regulation EPHB2 MAPK9 23755370 945384 Positive_regulation EPHB2 MAPK9 23762493 2804214 Positive_regulation EPHB2 MAPK9 23951028 2833302 Positive_regulation EPHB2 MAPK9 24058556 2848009 Positive_regulation EPHB2 MAPK9 24098984 1726338 Positive_regulation EPHB2 MAPK9 24421891 2909290 Positive_regulation EPHB2 MAPK9 24741325 487717 Positive_regulation EPHB2 MAPK9 24862327 680610 Positive_regulation EPHB2 MAPK9 25258648 1240890 Positive_regulation EPHB2 MAPK9 25268615 1131277 Positive_regulation EPHB2 MAPK9 25299961 174468 Positive_regulation EPHB2 MAPKAPK3 22870894 802953 Positive_regulation EPHB2 MARK2 22206009 2584143 Positive_regulation EPHB2 MAT2B 24212770 498209 Positive_regulation EPHB2 MATK 21772273 1933153 Positive_regulation EPHB2 MATK 21772273 1933166 Positive_regulation EPHB2 MATK 21772273 1933176 Positive_regulation EPHB2 MATK 21772273 1933182 Positive_regulation EPHB2 MBOAT2 24205284 2875892 Positive_regulation EPHB2 MBP 23658734 2789999 Positive_regulation EPHB2 MBTPS1 16566826 480339 Positive_regulation EPHB2 MBTPS1 16566826 480340 Positive_regulation EPHB2 MBTPS1 16566826 480341 Positive_regulation EPHB2 MBTPS1 16566826 480342 Positive_regulation EPHB2 MBTPS1 16847102 1331293 Positive_regulation EPHB2 MBTPS1 17449940 1634824 Positive_regulation EPHB2 MBTPS1 17449940 1634826 Positive_regulation EPHB2 MBTPS1 17449940 1634827 Positive_regulation EPHB2 MBTPS1 17449940 1634828 Positive_regulation EPHB2 MBTPS1 19077254 385111 Positive_regulation EPHB2 MBTPS1 19077254 385120 Positive_regulation EPHB2 MBTPS1 19077254 385140 Positive_regulation EPHB2 MBTPS1 21686182 1091054 Positive_regulation EPHB2 MBTPS1 22363147 88168 Positive_regulation EPHB2 MBTPS1 23706742 517228 Positive_regulation EPHB2 MBTPS1 23706742 517299 Positive_regulation EPHB2 MBTPS1 24420784 1890488 Positive_regulation EPHB2 MBTPS1 24832383 152792 Positive_regulation EPHB2 MBTPS1 24855377 2122936 Positive_regulation EPHB2 MBTPS1 24970174 208680 Positive_regulation EPHB2 MBTPS1 24970177 208704 Positive_regulation EPHB2 MBTPS1 25147438 1761256 Positive_regulation EPHB2 MBTPS1 PMC4052545 2247025 Positive_regulation EPHB2 MC1R 21931793 2554565 Positive_regulation EPHB2 MCC 22842345 1957633 Positive_regulation EPHB2 MCHR1 23626585 878363 Positive_regulation EPHB2 MCL1 22403613 2609012 Positive_regulation EPHB2 MCL1 23056582 2702353 Positive_regulation EPHB2 MCL1 24327018 442631 Positive_regulation EPHB2 MCOLN1 24223965 2877506 Positive_regulation EPHB2 MCTS1 23211466 2181780 Positive_regulation EPHB2 MDK 25380037 3023902 Positive_regulation EPHB2 MED1 22027397 1660050 Positive_regulation EPHB2 MED10 22027397 1660046 Positive_regulation EPHB2 MED11 22027397 1660049 Positive_regulation EPHB2 MED12 22027397 1660021 Positive_regulation EPHB2 MED13 22027397 1660031 Positive_regulation EPHB2 MED13L 22027397 1660032 Positive_regulation EPHB2 MED14 22027397 1660036 Positive_regulation EPHB2 MED15 22027397 1660022 Positive_regulation EPHB2 MED16 22027397 1660025 Positive_regulation EPHB2 MED17 22027397 1660038 Positive_regulation EPHB2 MED18 22027397 1660045 Positive_regulation EPHB2 MED19 22027397 1660048 Positive_regulation EPHB2 MED20 22027397 1660024 Positive_regulation EPHB2 MED21 22027397 1660019 Positive_regulation EPHB2 MED22 22027397 1660020 Positive_regulation EPHB2 MED23 22027397 1660037 Positive_regulation EPHB2 MED24 22027397 1660033 Positive_regulation EPHB2 MED25 22027397 1660047 Positive_regulation EPHB2 MED26 22027397 1660039 Positive_regulation EPHB2 MED27 22027397 1660040 Positive_regulation EPHB2 MED28 22027397 1660043 Positive_regulation EPHB2 MED29 22027397 1660035 Positive_regulation EPHB2 MED30 22027397 1660034 Positive_regulation EPHB2 MED31 22027397 1660042 Positive_regulation EPHB2 MED4 22027397 1660027 Positive_regulation EPHB2 MED6 22027397 1660029 Positive_regulation EPHB2 MED7 22027397 1660041 Positive_regulation EPHB2 MED8 22027397 1660030 Positive_regulation EPHB2 MED9 22027397 1660044 Positive_regulation EPHB2 MERTK 23353780 218313 Positive_regulation EPHB2 MET 20462959 1776133 Positive_regulation EPHB2 MET 21847121 437671 Positive_regulation EPHB2 MET 22157681 1961832 Positive_regulation EPHB2 MET 22962472 162647 Positive_regulation EPHB2 MET 24263233 840058 Positive_regulation EPHB2 MET 24287743 502468 Positive_regulation EPHB2 MET 24709879 617273 Positive_regulation EPHB2 MET 24727648 2188846 Positive_regulation EPHB2 MET 24744103 494821 Positive_regulation EPHB2 MET 25057499 195516 Positive_regulation EPHB2 MET 25162296 3002593 Positive_regulation EPHB2 METAP2 22384111 2604283 Positive_regulation EPHB2 MIF 19703290 1625532 Positive_regulation EPHB2 MIF 20721355 1143768 Positive_regulation EPHB2 MIF 20805118 3091065 Positive_regulation EPHB2 MIF 21209875 2491653 Positive_regulation EPHB2 MIF 21283538 2495570 Positive_regulation EPHB2 MIF 21283538 2495571 Positive_regulation EPHB2 MIF 21283538 2495579 Positive_regulation EPHB2 MIF 21283538 2495580 Positive_regulation EPHB2 MIF 21283538 2495581 Positive_regulation EPHB2 MIF 21283538 2495586 Positive_regulation EPHB2 MIF 21283538 2495587 Positive_regulation EPHB2 MIF 21283538 2495593 Positive_regulation EPHB2 MIF 21283538 2495594 Positive_regulation EPHB2 MIF 21283538 2495596 Positive_regulation EPHB2 MIF 21283538 2495604 Positive_regulation EPHB2 MIF 23522304 483065 Positive_regulation EPHB2 MIF 25015194 2195709 Positive_regulation EPHB2 MIF PMC2833918 134432 Positive_regulation EPHB2 MIR330 24736727 2953498 Positive_regulation EPHB2 MITF 23261059 219939 Positive_regulation EPHB2 MITF 24129178 1113329 Positive_regulation EPHB2 MKKS 25101059 927157 Positive_regulation EPHB2 MKNK1 17622349 2376989 Positive_regulation EPHB2 MKNK1 19300492 3043441 Positive_regulation EPHB2 MLST8 22028687 860489 Positive_regulation EPHB2 MLST8 24212820 498687 Positive_regulation EPHB2 MLST8 24312679 2890609 Positive_regulation EPHB2 MLST8 25493642 3033416 Positive_regulation EPHB2 MMP1 18629305 793116 Positive_regulation EPHB2 MMP1 21878106 3169105 Positive_regulation EPHB2 MMP1 22262460 1799777 Positive_regulation EPHB2 MMP1 22262460 1799778 Positive_regulation EPHB2 MMP1 22262460 1799781 Positive_regulation EPHB2 MMP1 22262460 1799788 Positive_regulation EPHB2 MMP1 24352036 1632443 Positive_regulation EPHB2 MMP1 25421240 1135140 Positive_regulation EPHB2 MMP10 18629305 793117 Positive_regulation EPHB2 MMP10 21878106 3169106 Positive_regulation EPHB2 MMP10 25421240 1135141 Positive_regulation EPHB2 MMP11 18629305 793118 Positive_regulation EPHB2 MMP11 21878106 3169107 Positive_regulation EPHB2 MMP11 25421240 1135142 Positive_regulation EPHB2 MMP12 18629305 793119 Positive_regulation EPHB2 MMP12 21878106 3169108 Positive_regulation EPHB2 MMP12 25421240 1135143 Positive_regulation EPHB2 MMP13 18629305 793120 Positive_regulation EPHB2 MMP13 21878106 3169109 Positive_regulation EPHB2 MMP13 25121739 2997339 Positive_regulation EPHB2 MMP13 25421240 1135144 Positive_regulation EPHB2 MMP14 18629305 793121 Positive_regulation EPHB2 MMP14 21860412 2141945 Positive_regulation EPHB2 MMP14 21878106 3169110 Positive_regulation EPHB2 MMP14 24180670 270281 Positive_regulation EPHB2 MMP14 24180670 270287 Positive_regulation EPHB2 MMP14 25421240 1135145 Positive_regulation EPHB2 MMP15 18629305 793122 Positive_regulation EPHB2 MMP15 21878106 3169111 Positive_regulation EPHB2 MMP15 25421240 1135146 Positive_regulation EPHB2 MMP16 18629305 793123 Positive_regulation EPHB2 MMP16 21878106 3169112 Positive_regulation EPHB2 MMP16 25421240 1135147 Positive_regulation EPHB2 MMP17 18629305 793124 Positive_regulation EPHB2 MMP17 21878106 3169113 Positive_regulation EPHB2 MMP17 25421240 1135148 Positive_regulation EPHB2 MMP19 18629305 793125 Positive_regulation EPHB2 MMP19 21878106 3169114 Positive_regulation EPHB2 MMP19 25421240 1135149 Positive_regulation EPHB2 MMP2 18629305 793126 Positive_regulation EPHB2 MMP2 21878106 3169115 Positive_regulation EPHB2 MMP2 25421240 1135150 Positive_regulation EPHB2 MMP20 18629305 793127 Positive_regulation EPHB2 MMP20 21878106 3169116 Positive_regulation EPHB2 MMP20 25421240 1135151 Positive_regulation EPHB2 MMP21 18629305 793114 Positive_regulation EPHB2 MMP21 21878106 3169103 Positive_regulation EPHB2 MMP21 25421240 1135135 Positive_regulation EPHB2 MMP24 18629305 793128 Positive_regulation EPHB2 MMP24 21878106 3169117 Positive_regulation EPHB2 MMP24 25421240 1135152 Positive_regulation EPHB2 MMP25 18629305 793111 Positive_regulation EPHB2 MMP25 21878106 3169100 Positive_regulation EPHB2 MMP25 25421240 1135132 Positive_regulation EPHB2 MMP26 18629305 793112 Positive_regulation EPHB2 MMP26 21878106 3169101 Positive_regulation EPHB2 MMP26 25421240 1135133 Positive_regulation EPHB2 MMP27 18629305 793113 Positive_regulation EPHB2 MMP27 21878106 3169102 Positive_regulation EPHB2 MMP27 25421240 1135134 Positive_regulation EPHB2 MMP28 18629305 793115 Positive_regulation EPHB2 MMP28 21878106 3169104 Positive_regulation EPHB2 MMP28 25421240 1135136 Positive_regulation EPHB2 MMP3 18629305 793129 Positive_regulation EPHB2 MMP3 21878106 3169118 Positive_regulation EPHB2 MMP3 25421240 1135153 Positive_regulation EPHB2 MMP7 18629305 793130 Positive_regulation EPHB2 MMP7 21878106 3169119 Positive_regulation EPHB2 MMP7 25421240 1135154 Positive_regulation EPHB2 MMP8 18629305 793131 Positive_regulation EPHB2 MMP8 21878106 3169120 Positive_regulation EPHB2 MMP8 25421240 1135155 Positive_regulation EPHB2 MMP9 18629305 793132 Positive_regulation EPHB2 MMP9 20847954 1747914 Positive_regulation EPHB2 MMP9 20847954 1747915 Positive_regulation EPHB2 MMP9 21878106 3169121 Positive_regulation EPHB2 MMP9 22590514 2640934 Positive_regulation EPHB2 MMP9 23451269 2758484 Positive_regulation EPHB2 MMP9 24132149 1113449 Positive_regulation EPHB2 MMP9 24824968 2969532 Positive_regulation EPHB2 MMP9 25421240 1135156 Positive_regulation EPHB2 MMP9 25499743 476669 Positive_regulation EPHB2 MOCOS 11877481 1523106 Positive_regulation EPHB2 MOK 24952599 2192909 Positive_regulation EPHB2 MPL 20838657 2272428 Positive_regulation EPHB2 MRE11A 16787538 3096299 Positive_regulation EPHB2 MRE11A 19804630 401937 Positive_regulation EPHB2 MRE11A 23758320 151622 Positive_regulation EPHB2 MRE11A 23758320 151640 Positive_regulation EPHB2 MRXS5 19684611 8013 Positive_regulation EPHB2 MSK10 19052640 2401858 Positive_regulation EPHB2 MSK32 19052640 2401859 Positive_regulation EPHB2 MSK38 19052640 2401860 Positive_regulation EPHB2 MSK9 19052640 2401861 Positive_regulation EPHB2 MSLN 23694968 3135781 Positive_regulation EPHB2 MSLN 23694968 3135810 Positive_regulation EPHB2 MSLN 23694968 3135816 Positive_regulation EPHB2 MSX2 20682066 465994 Positive_regulation EPHB2 MTMR8 20815916 304187 Positive_regulation EPHB2 MTOR 20472883 2007905 Positive_regulation EPHB2 MTOR 21278786 2137745 Positive_regulation EPHB2 MTOR 22028687 860491 Positive_regulation EPHB2 MTOR 22159814 1140671 Positive_regulation EPHB2 MTOR 23077579 2704806 Positive_regulation EPHB2 MTOR 23818927 820589 Positive_regulation EPHB2 MTOR 24212820 498689 Positive_regulation EPHB2 MTOR 24312679 2890611 Positive_regulation EPHB2 MTOR 25344914 2206115 Positive_regulation EPHB2 MTOR 25364579 478548 Positive_regulation EPHB2 MTOR 25493642 3033418 Positive_regulation EPHB2 MTX1 22984629 2689654 Positive_regulation EPHB2 MUC1 17391532 3108047 Positive_regulation EPHB2 MUC1 22457794 2613744 Positive_regulation EPHB2 MUC1 22457794 2613745 Positive_regulation EPHB2 MUC1 22457794 2613746 Positive_regulation EPHB2 MUC1 22457794 2613759 Positive_regulation EPHB2 MUC1 22457794 2613769 Positive_regulation EPHB2 MUC1 24770886 2189518 Positive_regulation EPHB2 MUC12 17391532 3108048 Positive_regulation EPHB2 MUC13 17391532 3108049 Positive_regulation EPHB2 MUC15 17391532 3108041 Positive_regulation EPHB2 MUC16 17391532 3108042 Positive_regulation EPHB2 MUC16 23694968 3135780 Positive_regulation EPHB2 MUC17 17391532 3108043 Positive_regulation EPHB2 MUC19 17391532 3108040 Positive_regulation EPHB2 MUC2 17391532 3108050 Positive_regulation EPHB2 MUC20 17391532 3108045 Positive_regulation EPHB2 MUC21 17391532 3108044 Positive_regulation EPHB2 MUC22 17391532 3108046 Positive_regulation EPHB2 MUC4 17391532 3108051 Positive_regulation EPHB2 MUC6 17391532 3108052 Positive_regulation EPHB2 MUC7 17391532 3108053 Positive_regulation EPHB2 MUC8 17391532 3108054 Positive_regulation EPHB2 MYD88 20473309 1961031 Positive_regulation EPHB2 MYD88 20473309 1961042 Positive_regulation EPHB2 MYD88 20473309 1961043 Positive_regulation EPHB2 MYD88 20473309 1961044 Positive_regulation EPHB2 MYD88 23382911 2746743 Positive_regulation EPHB2 MYD88 25101851 2995835 Positive_regulation EPHB2 MYD88 PMC4072289 1623757 Positive_regulation EPHB2 MYL12B 23969997 839533 Positive_regulation EPHB2 MYLIP 20444294 1228413 Positive_regulation EPHB2 MYLIP 22162462 776972 Positive_regulation EPHB2 MYLIP 22507670 125405 Positive_regulation EPHB2 MYLIP 22876303 2672730 Positive_regulation EPHB2 MYLIP 23054677 1890312 Positive_regulation EPHB2 MYLIP 23469214 2763226 Positive_regulation EPHB2 MYLIP 23469214 2763238 Positive_regulation EPHB2 MYLIP 23469214 2763278 Positive_regulation EPHB2 MYLIP 23874686 2822006 Positive_regulation EPHB2 MYLIP 23874686 2822007 Positive_regulation EPHB2 MYLIP 24009080 2184722 Positive_regulation EPHB2 MYLIP 24009080 2184725 Positive_regulation EPHB2 MYLIP 24336080 570365 Positive_regulation EPHB2 MYLIP 24550252 752904 Positive_regulation EPHB2 MYLIP 24587182 2928996 Positive_regulation EPHB2 MYLIP 25058005 2992030 Positive_regulation EPHB2 MYLIP 25058005 2992047 Positive_regulation EPHB2 MYLIP 25058496 2360929 Positive_regulation EPHB2 MYLIP 25247240 1906168 Positive_regulation EPHB2 MYLIP 25275294 2202361 Positive_regulation EPHB2 MYLIP 25275294 2202462 Positive_regulation EPHB2 MYLIP 25275294 2202490 Positive_regulation EPHB2 MYLIP 25275294 2202532 Positive_regulation EPHB2 MYLIP 25275294 2202589 Positive_regulation EPHB2 MYLIP 25275294 2202617 Positive_regulation EPHB2 MYLIP 25352952 987301 Positive_regulation EPHB2 MYLIP 25396727 3026970 Positive_regulation EPHB2 MYLK 10747099 1257028 Positive_regulation EPHB2 MYLK 23969997 839534 Positive_regulation EPHB2 MYO10 24069528 750730 Positive_regulation EPHB2 MYO16 24069528 750728 Positive_regulation EPHB2 MYO19 24069528 750727 Positive_regulation EPHB2 MYO6 24069528 750731 Positive_regulation EPHB2 MYOCD 23855625 1232448 Positive_regulation EPHB2 MYOG 21048967 2480249 Positive_regulation EPHB2 NA 18629305 793384 Positive_regulation EPHB2 NACC1 16512905 383199 Positive_regulation EPHB2 NACC2 16512905 383200 Positive_regulation EPHB2 NBN 21208456 1228795 Positive_regulation EPHB2 NCAM1 25110505 3085912 Positive_regulation EPHB2 NCAM2 25110505 3085913 Positive_regulation EPHB2 NCK1 10477763 1249326 Positive_regulation EPHB2 NCK1 24670066 539887 Positive_regulation EPHB2 NCOA3 23388133 267740 Positive_regulation EPHB2 NCOA3 23388133 267751 Positive_regulation EPHB2 NCOA3 23388133 267761 Positive_regulation EPHB2 NDRG1 23717685 2798752 Positive_regulation EPHB2 NDUFB11 23268649 356168 Positive_regulation EPHB2 NEDD9 21829474 2541157 Positive_regulation EPHB2 NEDD9 21829474 2541161 Positive_regulation EPHB2 NELL2 24465772 2911730 Positive_regulation EPHB2 NELL2 24465772 2911737 Positive_regulation EPHB2 NELL2 24465772 2911743 Positive_regulation EPHB2 NELL2 24465772 2911750 Positive_regulation EPHB2 NENF 23805070 938227 Positive_regulation EPHB2 NEUROD1 23717400 2797563 Positive_regulation EPHB2 NEUROD1 24744103 494771 Positive_regulation EPHB2 NEUROD2 23717400 2797564 Positive_regulation EPHB2 NEUROD2 24744103 494772 Positive_regulation EPHB2 NEUROD4 23717400 2797561 Positive_regulation EPHB2 NEUROD4 24744103 494768 Positive_regulation EPHB2 NEUROD6 23717400 2797562 Positive_regulation EPHB2 NEUROD6 24744103 494769 Positive_regulation EPHB2 NF1 23145129 2715901 Positive_regulation EPHB2 NF1 24278035 2353138 Positive_regulation EPHB2 NF2 20163697 526483 Positive_regulation EPHB2 NFATC2 19724275 432704 Positive_regulation EPHB2 NFATC3 22298426 1800004 Positive_regulation EPHB2 NFE2L2 21270272 717460 Positive_regulation EPHB2 NFE2L2 21270272 717461 Positive_regulation EPHB2 NFE2L2 24846271 2972149 Positive_regulation EPHB2 NFKB1 24983623 2985726 Positive_regulation EPHB2 NGF 10477751 1249170 Positive_regulation EPHB2 NGF 11737890 457301 Positive_regulation EPHB2 NGF 12184796 389984 Positive_regulation EPHB2 NGF 14662744 1302186 Positive_regulation EPHB2 NGF 14981116 1531640 Positive_regulation EPHB2 NGF 17724123 1344126 Positive_regulation EPHB2 NGF 17724123 1344266 Positive_regulation EPHB2 NGF 18463697 2289730 Positive_regulation EPHB2 NGF 19292901 401665 Positive_regulation EPHB2 NGF 19357636 1902901 Positive_regulation EPHB2 NGF 19517027 671870 Positive_regulation EPHB2 NGF 19804630 401952 Positive_regulation EPHB2 NGF 19804630 401968 Positive_regulation EPHB2 NGF 19864463 1770369 Positive_regulation EPHB2 NGF 20300619 2443883 Positive_regulation EPHB2 NGF 20376360 2445397 Positive_regulation EPHB2 NGF 20376360 2445398 Positive_regulation EPHB2 NGF 20376360 2445399 Positive_regulation EPHB2 NGF 20376360 2445421 Positive_regulation EPHB2 NGF 21298006 2499321 Positive_regulation EPHB2 NGF 21412436 2507988 Positive_regulation EPHB2 NGF 21738764 2533726 Positive_regulation EPHB2 NGF 21849472 1793452 Positive_regulation EPHB2 NGF 22140566 2576810 Positive_regulation EPHB2 NGF 22384148 2606840 Positive_regulation EPHB2 NGF 22384148 2606841 Positive_regulation EPHB2 NGF 22384148 2606981 Positive_regulation EPHB2 NGF 22404972 528348 Positive_regulation EPHB2 NGF 22528856 161525 Positive_regulation EPHB2 NGF 22754300 1095932 Positive_regulation EPHB2 NGF 22931352 1231145 Positive_regulation EPHB2 NGF 23060802 959344 Positive_regulation EPHB2 NGF 23213379 167778 Positive_regulation EPHB2 NGF 23213379 167779 Positive_regulation EPHB2 NGF 23213379 167781 Positive_regulation EPHB2 NGF 23412386 559927 Positive_regulation EPHB2 NGF 23598414 561508 Positive_regulation EPHB2 NGF 23598414 561520 Positive_regulation EPHB2 NGF 23717400 2797565 Positive_regulation EPHB2 NGF 23999075 2235843 Positive_regulation EPHB2 NGF 23999075 2235844 Positive_regulation EPHB2 NGF 24006492 1818268 Positive_regulation EPHB2 NGF 24040018 2845234 Positive_regulation EPHB2 NGF 24119372 1651391 Positive_regulation EPHB2 NGF 24270184 1968739 Positive_regulation EPHB2 NGF 24386191 2902945 Positive_regulation EPHB2 NGF 24667437 2938716 Positive_regulation EPHB2 NGF 24992156 2301081 Positive_regulation EPHB2 NGF 25006578 194387 Positive_regulation EPHB2 NGF 25051506 1886548 Positive_regulation EPHB2 NGF 25149537 2198466 Positive_regulation EPHB2 NGF 25191523 588141 Positive_regulation EPHB2 NGF 25249457 704766 Positive_regulation EPHB2 NGF 25514808 3034799 Positive_regulation EPHB2 NGF 25514808 3034800 Positive_regulation EPHB2 NGF 25514808 3034808 Positive_regulation EPHB2 NGF 25514808 3034835 Positive_regulation EPHB2 NGF 25514808 3035002 Positive_regulation EPHB2 NGF 25514808 3035009 Positive_regulation EPHB2 NKX2-1 23155002 1809598 Positive_regulation EPHB2 NLRP6 22763455 1988838 Positive_regulation EPHB2 NLRP6 22763455 1988840 Positive_regulation EPHB2 NME1 24829611 1650628 Positive_regulation EPHB2 NME2 24829611 1650629 Positive_regulation EPHB2 NNAT 18591389 706330 Positive_regulation EPHB2 NNAT 18591389 706344 Positive_regulation EPHB2 NOD2 25090227 2995093 Positive_regulation EPHB2 NOS1 23227003 932706 Positive_regulation EPHB2 NOTCH1 22004682 1863748 Positive_regulation EPHB2 NOTCH1 24201804 568925 Positive_regulation EPHB2 NOTCH1 24201804 568930 Positive_regulation EPHB2 NOTCH1 25166211 3003686 Positive_regulation EPHB2 NOTCH2 22004682 1863749 Positive_regulation EPHB2 NOTCH2 25166211 3003687 Positive_regulation EPHB2 NOTCH3 22004682 1863750 Positive_regulation EPHB2 NOTCH3 25166211 3003688 Positive_regulation EPHB2 NOTCH4 22004682 1863751 Positive_regulation EPHB2 NOTCH4 25166211 3003689 Positive_regulation EPHB2 NOX1 19804648 1835304 Positive_regulation EPHB2 NOX1 19804648 1835305 Positive_regulation EPHB2 NOX1 19804648 1835306 Positive_regulation EPHB2 NOX1 19804648 1835307 Positive_regulation EPHB2 NOX1 19804648 1835308 Positive_regulation EPHB2 NOX1 19804648 1835309 Positive_regulation EPHB2 NOX1 19804648 1835323 Positive_regulation EPHB2 NOX1 19804648 1835327 Positive_regulation EPHB2 NOX1 22933112 724419 Positive_regulation EPHB2 NOX1 22934082 958795 Positive_regulation EPHB2 NOX1 24192910 1920119 Positive_regulation EPHB2 NOX1 24192910 1920123 Positive_regulation EPHB2 NOX3 19804648 1835310 Positive_regulation EPHB2 NOX3 19804648 1835311 Positive_regulation EPHB2 NOX3 19804648 1835312 Positive_regulation EPHB2 NOX3 19804648 1835313 Positive_regulation EPHB2 NOX3 19804648 1835314 Positive_regulation EPHB2 NOX3 19804648 1835315 Positive_regulation EPHB2 NOX3 19804648 1835324 Positive_regulation EPHB2 NOX3 19804648 1835328 Positive_regulation EPHB2 NOX3 22933112 724420 Positive_regulation EPHB2 NOX3 22934082 958796 Positive_regulation EPHB2 NOX4 18573911 1352971 Positive_regulation EPHB2 NOX4 19804648 1835316 Positive_regulation EPHB2 NOX4 19804648 1835317 Positive_regulation EPHB2 NOX4 19804648 1835318 Positive_regulation EPHB2 NOX4 19804648 1835319 Positive_regulation EPHB2 NOX4 19804648 1835320 Positive_regulation EPHB2 NOX4 19804648 1835321 Positive_regulation EPHB2 NOX4 19804648 1835325 Positive_regulation EPHB2 NOX4 19804648 1835329 Positive_regulation EPHB2 NOX4 22933112 724421 Positive_regulation EPHB2 NOX4 22934082 958797 Positive_regulation EPHB2 NOX5 19804648 1835298 Positive_regulation EPHB2 NOX5 19804648 1835299 Positive_regulation EPHB2 NOX5 19804648 1835300 Positive_regulation EPHB2 NOX5 19804648 1835301 Positive_regulation EPHB2 NOX5 19804648 1835302 Positive_regulation EPHB2 NOX5 19804648 1835303 Positive_regulation EPHB2 NOX5 19804648 1835322 Positive_regulation EPHB2 NOX5 19804648 1835326 Positive_regulation EPHB2 NOX5 22933112 724418 Positive_regulation EPHB2 NOX5 22934082 958794 Positive_regulation EPHB2 NPM1 22852078 1689203 Positive_regulation EPHB2 NPS 24624962 1921245 Positive_regulation EPHB2 NPY 18382618 831307 Positive_regulation EPHB2 NPY4R 23359326 2744880 Positive_regulation EPHB2 NPY6R 16674821 1624916 Positive_regulation EPHB2 NR2F1 24906407 273663 Positive_regulation EPHB2 NR3C1 22529971 2620797 Positive_regulation EPHB2 NR5A1 24312080 879565 Positive_regulation EPHB2 NRAS 12516548 2001297 Positive_regulation EPHB2 NRAS 15969750 1844733 Positive_regulation EPHB2 NRAS 17319972 1645348 Positive_regulation EPHB2 NRAS 17449939 1634810 Positive_regulation EPHB2 NRAS 17449939 1634811 Positive_regulation EPHB2 NRAS 17498287 999293 Positive_regulation EPHB2 NRAS 17498287 999296 Positive_regulation EPHB2 NRAS 18030338 2381003 Positive_regulation EPHB2 NRAS 18335053 2386985 Positive_regulation EPHB2 NRAS 18404483 3088022 Positive_regulation EPHB2 NRAS 18404483 3088052 Positive_regulation EPHB2 NRAS 18463697 2289743 Positive_regulation EPHB2 NRAS 18925939 2000819 Positive_regulation EPHB2 NRAS 18949068 2207996 Positive_regulation EPHB2 NRAS 19015320 1361481 Positive_regulation EPHB2 NRAS 19025606 1646457 Positive_regulation EPHB2 NRAS 19025606 1646460 Positive_regulation EPHB2 NRAS 19063885 850716 Positive_regulation EPHB2 NRAS 19137382 621160 Positive_regulation EPHB2 NRAS 19137382 621170 Positive_regulation EPHB2 NRAS 19238206 2406126 Positive_regulation EPHB2 NRAS 19492026 3402 Positive_regulation EPHB2 NRAS 19682393 1646603 Positive_regulation EPHB2 NRAS 19707311 175378 Positive_regulation EPHB2 NRAS 19804630 401929 Positive_regulation EPHB2 NRAS 19804630 401953 Positive_regulation EPHB2 NRAS 19804630 401978 Positive_regulation EPHB2 NRAS 19804630 402003 Positive_regulation EPHB2 NRAS 19861649 505911 Positive_regulation EPHB2 NRAS 19878585 254552 Positive_regulation EPHB2 NRAS 20003375 254813 Positive_regulation EPHB2 NRAS 20071468 1772940 Positive_regulation EPHB2 NRAS 20071468 1772941 Positive_regulation EPHB2 NRAS 20071468 1772996 Positive_regulation EPHB2 NRAS 20071468 1773011 Positive_regulation EPHB2 NRAS 20141835 516321 Positive_regulation EPHB2 NRAS 20149136 2252474 Positive_regulation EPHB2 NRAS 20162012 1089711 Positive_regulation EPHB2 NRAS 20179705 1984094 Positive_regulation EPHB2 NRAS 20549726 701643 Positive_regulation EPHB2 NRAS 20663127 386302 Positive_regulation EPHB2 NRAS 20802521 2135574 Positive_regulation EPHB2 NRAS 21042537 2479651 Positive_regulation EPHB2 NRAS 21479172 2510915 Positive_regulation EPHB2 NRAS 21512581 2234288 Positive_regulation EPHB2 NRAS 21526160 2513804 Positive_regulation EPHB2 NRAS 21541658 616602 Positive_regulation EPHB2 NRAS 21756365 405131 Positive_regulation EPHB2 NRAS 21756365 405138 Positive_regulation EPHB2 NRAS 21831290 1505406 Positive_regulation EPHB2 NRAS 21887333 2549335 Positive_regulation EPHB2 NRAS 21980390 2560145 Positive_regulation EPHB2 NRAS 22319531 1067181 Positive_regulation EPHB2 NRAS 22363839 1687322 Positive_regulation EPHB2 NRAS 22384111 2605917 Positive_regulation EPHB2 NRAS 22384148 2607028 Positive_regulation EPHB2 NRAS 22419879 2120944 Positive_regulation EPHB2 NRAS 22523682 1687955 Positive_regulation EPHB2 NRAS 22971289 472100 Positive_regulation EPHB2 NRAS 23425254 3215212 Positive_regulation EPHB2 NRAS 23533771 1497060 Positive_regulation EPHB2 NRAS 23587357 734349 Positive_regulation EPHB2 NRAS 23626807 2784860 Positive_regulation EPHB2 NRAS 23690850 818988 Positive_regulation EPHB2 NRAS 23707528 614144 Positive_regulation EPHB2 NRAS 23741352 2800463 Positive_regulation EPHB2 NRAS 23758320 151520 Positive_regulation EPHB2 NRAS 23802073 2162521 Positive_regulation EPHB2 NRAS 23825558 2809659 Positive_regulation EPHB2 NRAS 24220297 1920140 Positive_regulation EPHB2 NRAS 24231770 545246 Positive_regulation EPHB2 NRAS 24265712 2884986 Positive_regulation EPHB2 NRAS 24324645 2890969 Positive_regulation EPHB2 NRAS 24330074 1482216 Positive_regulation EPHB2 NRAS 24396730 668238 Positive_regulation EPHB2 NRAS 24684778 1873584 Positive_regulation EPHB2 NRAS 24994118 2194892 Positive_regulation EPHB2 NRAS 25099740 1651937 Positive_regulation EPHB2 NRAS 25275324 3012021 Positive_regulation EPHB2 NRAS 25397617 3027238 Positive_regulation EPHB2 NRAS 9432981 1602479 Positive_regulation EPHB2 NRCAM 24023801 2843571 Positive_regulation EPHB2 NRCAM 24023801 2843574 Positive_regulation EPHB2 NRCAM 24023801 2843646 Positive_regulation EPHB2 NRG1 22758623 667977 Positive_regulation EPHB2 NRG1 24391468 2285189 Positive_regulation EPHB2 NRG2 22758623 667978 Positive_regulation EPHB2 NRG2 24391468 2285190 Positive_regulation EPHB2 NRG3 22758623 667979 Positive_regulation EPHB2 NRG3 24391468 2285191 Positive_regulation EPHB2 NRG4 22758623 667976 Positive_regulation EPHB2 NRG4 24391468 2285188 Positive_regulation EPHB2 NRN1 23066017 1205244 Positive_regulation EPHB2 NRN1 23066017 1205255 Positive_regulation EPHB2 NRN1 23066017 1205267 Positive_regulation EPHB2 NRN1 23066017 1205268 Positive_regulation EPHB2 NRN1 24225021 388857 Positive_regulation EPHB2 NRP1 21828096 703053 Positive_regulation EPHB2 NRP1 23639442 700601 Positive_regulation EPHB2 NRP1 23639442 700605 Positive_regulation EPHB2 NRP1 23639442 700606 Positive_regulation EPHB2 NRP1 23639442 700625 Positive_regulation EPHB2 NRTN 21450093 1898045 Positive_regulation EPHB2 NRTN 21450093 1898058 Positive_regulation EPHB2 NRTN 21450093 1898060 Positive_regulation EPHB2 NTRK1 20093365 1169002 Positive_regulation EPHB2 NTRK1 21501463 332670 Positive_regulation EPHB2 NTRK1 22384148 2606842 Positive_regulation EPHB2 NTRK1 22586581 722780 Positive_regulation EPHB2 NTRK1 22586581 722781 Positive_regulation EPHB2 NTRK1 23091515 1717451 Positive_regulation EPHB2 NTRK1 25051506 1886549 Positive_regulation EPHB2 NTRK2 19383130 525228 Positive_regulation EPHB2 NTRK2 19383130 525250 Positive_regulation EPHB2 NTRK2 20156366 255292 Positive_regulation EPHB2 NTRK2 20156366 255293 Positive_regulation EPHB2 NTRK2 21849472 1793453 Positive_regulation EPHB2 NTRK2 21958434 1659856 Positive_regulation EPHB2 NTRK2 23670594 1106684 Positive_regulation EPHB2 NTRK2 24503862 2920012 Positive_regulation EPHB2 NTRK2 25051506 1886550 Positive_regulation EPHB2 NTS 21961726 261112 Positive_regulation EPHB2 NTS 21961726 261113 Positive_regulation EPHB2 NTS 21961726 261114 Positive_regulation EPHB2 NTS 21961726 261115 Positive_regulation EPHB2 NTS 21961726 261116 Positive_regulation EPHB2 NTS 21961726 261160 Positive_regulation EPHB2 NTS 21961726 261161 Positive_regulation EPHB2 NTS 21961726 261252 Positive_regulation EPHB2 NTS 21961726 261253 Positive_regulation EPHB2 NTS 21961726 261299 Positive_regulation EPHB2 NTS 21961726 261300 Positive_regulation EPHB2 NTS 21961726 261314 Positive_regulation EPHB2 NTS 21961726 261315 Positive_regulation EPHB2 NTS 21961726 261336 Positive_regulation EPHB2 NTS 21961726 261337 Positive_regulation EPHB2 NTS 22967907 1506592 Positive_regulation EPHB2 NTS 23437362 2756675 Positive_regulation EPHB2 NTS 23437362 2756676 Positive_regulation EPHB2 NTS 23437362 2756696 Positive_regulation EPHB2 NTS 25249538 2201856 Positive_regulation EPHB2 NTS 25249545 2201890 Positive_regulation EPHB2 NTS 25493642 3033420 Positive_regulation EPHB2 NUP50 23455463 1102836 Positive_regulation EPHB2 OPN1MW 21317295 717918 Positive_regulation EPHB2 OPN1MW 24204703 2874087 Positive_regulation EPHB2 OSBP 18348724 1891062 Positive_regulation EPHB2 OSBPL2 18404483 3087905 Positive_regulation EPHB2 OSM 16271139 248966 Positive_regulation EPHB2 OSM 16271139 248967 Positive_regulation EPHB2 OSM 16271139 248968 Positive_regulation EPHB2 OSM 24060241 3102145 Positive_regulation EPHB2 OXT 24916153 399783 Positive_regulation EPHB2 OXT 24916153 399893 Positive_regulation EPHB2 P2RX7 21941410 1749408 Positive_regulation EPHB2 P2RX7 21941410 1749409 Positive_regulation EPHB2 P2RX7 22163032 2577872 Positive_regulation EPHB2 P2RX7 23907465 564622 Positive_regulation EPHB2 P2RY1 18404483 3087815 Positive_regulation EPHB2 P2RY1 18404483 3087914 Positive_regulation EPHB2 P2RY1 21505453 436703 Positive_regulation EPHB2 P2RY1 21505453 436762 Positive_regulation EPHB2 P2RY1 24191147 867709 Positive_regulation EPHB2 P2RY12 18343032 2012037 Positive_regulation EPHB2 P2RY12 18404483 3087814 Positive_regulation EPHB2 P2RY12 22899962 814922 Positive_regulation EPHB2 P2RY2 18404483 3087816 Positive_regulation EPHB2 P2RY2 18404483 3087915 Positive_regulation EPHB2 P2RY2 18404483 3087916 Positive_regulation EPHB2 PAEP 23528948 3134503 Positive_regulation EPHB2 PAF1 21298035 2499391 Positive_regulation EPHB2 PAF1 21298035 2499392 Positive_regulation EPHB2 PAF1 23911909 1637730 Positive_regulation EPHB2 PAF1 23911909 1637731 Positive_regulation EPHB2 PAF1 23911909 1637794 Positive_regulation EPHB2 PAF1 23911909 1637806 Positive_regulation EPHB2 PAF1 23911909 1637807 Positive_regulation EPHB2 PAF1 23911909 1637836 Positive_regulation EPHB2 PAF1 23911909 1637837 Positive_regulation EPHB2 PAF1 23911909 1637838 Positive_regulation EPHB2 PAF1 24886678 1618986 Positive_regulation EPHB2 PAF1 25261977 1510729 Positive_regulation EPHB2 PAK1 11134074 1266134 Positive_regulation EPHB2 PAK1 11581314 1521030 Positive_regulation EPHB2 PAK1 12952943 1296758 Positive_regulation EPHB2 PAK1 19187548 525090 Positive_regulation EPHB2 PAK1 20195469 2441866 Positive_regulation EPHB2 PAK1 20711231 2133570 Positive_regulation EPHB2 PAK1 20711231 2133716 Positive_regulation EPHB2 PAK1 21072183 2481247 Positive_regulation EPHB2 PAK1 21209852 2491374 Positive_regulation EPHB2 PAK1 21829671 2542279 Positive_regulation EPHB2 PAK1 22096607 2571977 Positive_regulation EPHB2 PAK1 22096607 2571997 Positive_regulation EPHB2 PAK1 23162742 589292 Positive_regulation EPHB2 PAK1 24324645 2890977 Positive_regulation EPHB2 PAK1 25335797 3071191 Positive_regulation EPHB2 PAK1 25335797 3071231 Positive_regulation EPHB2 PAK2 11134074 1266135 Positive_regulation EPHB2 PAK2 11581314 1521031 Positive_regulation EPHB2 PAK2 12952943 1296759 Positive_regulation EPHB2 PAK2 19187548 525091 Positive_regulation EPHB2 PAK2 20195469 2441867 Positive_regulation EPHB2 PAK2 20711231 2133571 Positive_regulation EPHB2 PAK2 20711231 2133717 Positive_regulation EPHB2 PAK2 21072183 2481248 Positive_regulation EPHB2 PAK2 22096607 2571978 Positive_regulation EPHB2 PAK2 23162742 589293 Positive_regulation EPHB2 PAK2 25379771 3023858 Positive_regulation EPHB2 PAK3 11134074 1266136 Positive_regulation EPHB2 PAK3 11581314 1521032 Positive_regulation EPHB2 PAK3 12952943 1296760 Positive_regulation EPHB2 PAK3 19187548 525092 Positive_regulation EPHB2 PAK3 20195469 2441868 Positive_regulation EPHB2 PAK3 20711231 2133572 Positive_regulation EPHB2 PAK3 20711231 2133718 Positive_regulation EPHB2 PAK3 21072183 2481249 Positive_regulation EPHB2 PAK3 22096607 2571979 Positive_regulation EPHB2 PAK3 23162742 589294 Positive_regulation EPHB2 PAK4 11134074 1266132 Positive_regulation EPHB2 PAK4 11581314 1521028 Positive_regulation EPHB2 PAK4 12952943 1296732 Positive_regulation EPHB2 PAK4 19187548 525088 Positive_regulation EPHB2 PAK4 20195469 2441864 Positive_regulation EPHB2 PAK4 20711231 2133568 Positive_regulation EPHB2 PAK4 20711231 2133714 Positive_regulation EPHB2 PAK4 21072183 2481245 Positive_regulation EPHB2 PAK4 22096607 2571975 Positive_regulation EPHB2 PAK4 23162742 589290 Positive_regulation EPHB2 PAK4 24471762 214343 Positive_regulation EPHB2 PAK6 11134074 1266133 Positive_regulation EPHB2 PAK6 11581314 1521029 Positive_regulation EPHB2 PAK6 12952943 1296733 Positive_regulation EPHB2 PAK6 19187548 525089 Positive_regulation EPHB2 PAK6 20195469 2441865 Positive_regulation EPHB2 PAK6 20711231 2133569 Positive_regulation EPHB2 PAK6 20711231 2133715 Positive_regulation EPHB2 PAK6 21072183 2481246 Positive_regulation EPHB2 PAK6 22096607 2571976 Positive_regulation EPHB2 PAK6 23162742 589291 Positive_regulation EPHB2 PAK7 11134074 1266131 Positive_regulation EPHB2 PAK7 11581314 1521027 Positive_regulation EPHB2 PAK7 12952943 1296731 Positive_regulation EPHB2 PAK7 19187548 525087 Positive_regulation EPHB2 PAK7 20195469 2441863 Positive_regulation EPHB2 PAK7 20711231 2133567 Positive_regulation EPHB2 PAK7 20711231 2133713 Positive_regulation EPHB2 PAK7 21072183 2481244 Positive_regulation EPHB2 PAK7 22096607 2571974 Positive_regulation EPHB2 PAK7 23162742 589289 Positive_regulation EPHB2 PAM 21042538 2479709 Positive_regulation EPHB2 PAM 22783258 902311 Positive_regulation EPHB2 PAM 24205328 2876020 Positive_regulation EPHB2 PAPSS1 22312298 1094929 Positive_regulation EPHB2 PARP1 16787538 3096290 Positive_regulation EPHB2 PARP1 19804630 401934 Positive_regulation EPHB2 PARP1 19891779 464974 Positive_regulation EPHB2 PARP1 19891779 464976 Positive_regulation EPHB2 PARP1 23758320 151620 Positive_regulation EPHB2 PARP1 23758320 151638 Positive_regulation EPHB2 PARP1 24350055 946645 Positive_regulation EPHB2 PARP1 24586933 2928422 Positive_regulation EPHB2 PARP1 24611016 2122762 Positive_regulation EPHB2 PARP1 25089620 2994557 Positive_regulation EPHB2 PARP1 25089620 2994565 Positive_regulation EPHB2 PARP10 24611016 2122757 Positive_regulation EPHB2 PARP11 24611016 2122753 Positive_regulation EPHB2 PARP12 24611016 2122755 Positive_regulation EPHB2 PARP14 24611016 2122766 Positive_regulation EPHB2 PARP15 24611016 2122760 Positive_regulation EPHB2 PARP16 24611016 2122758 Positive_regulation EPHB2 PARP2 24611016 2122764 Positive_regulation EPHB2 PARP3 24611016 2122765 Positive_regulation EPHB2 PARP4 24611016 2122763 Positive_regulation EPHB2 PARP6 24611016 2122761 Positive_regulation EPHB2 PARP8 24611016 2122759 Positive_regulation EPHB2 PARP9 24611016 2122756 Positive_regulation EPHB2 PARVA 15353548 1311978 Positive_regulation EPHB2 PBRM1 18053252 3212133 Positive_regulation EPHB2 PCMT1 21841813 13269 Positive_regulation EPHB2 PCYT1A 24847227 861126 Positive_regulation EPHB2 PCYT1A 24847227 861127 Positive_regulation EPHB2 PCYT1A 24847227 861128 Positive_regulation EPHB2 PCYT1A 24847227 861131 Positive_regulation EPHB2 PDC 21364884 2504363 Positive_regulation EPHB2 PDCD4 23469214 2763268 Positive_regulation EPHB2 PDE4D 20819076 148118 Positive_regulation EPHB2 PDE6D 20979602 3111542 Positive_regulation EPHB2 PDGFA 24403605 1820412 Positive_regulation EPHB2 PDGFB 17591920 1341664 Positive_regulation EPHB2 PDGFB 17591920 1341674 Positive_regulation EPHB2 PDGFB 17987121 2380291 Positive_regulation EPHB2 PDGFB 21537407 730245 Positive_regulation EPHB2 PDGFB 22315595 1673237 Positive_regulation EPHB2 PDGFB 22315595 1673267 Positive_regulation EPHB2 PDGFB 22315595 1673282 Positive_regulation EPHB2 PDGFB 23198981 1665403 Positive_regulation EPHB2 PDGFB 23457620 2759190 Positive_regulation EPHB2 PDGFB 23457620 2759203 Positive_regulation EPHB2 PDGFB 24580756 295917 Positive_regulation EPHB2 PDGFB 24732420 2952100 Positive_regulation EPHB2 PDGFRB 18312689 1003644 Positive_regulation EPHB2 PDGFRB 18312689 1003648 Positive_regulation EPHB2 PDGFRB 18312689 1003649 Positive_regulation EPHB2 PDGFRB 18312689 1003656 Positive_regulation EPHB2 PDGFRB 19718435 2425427 Positive_regulation EPHB2 PDGFRB 22984590 2689335 Positive_regulation EPHB2 PDGFRB 23686014 2117379 Positive_regulation EPHB2 PDK1 21779235 928015 Positive_regulation EPHB2 PDK4 24457597 2186880 Positive_regulation EPHB2 PDLIM7 14981114 1531610 Positive_regulation EPHB2 PDLIM7 18490492 1551308 Positive_regulation EPHB2 PDLIM7 21975125 3214404 Positive_regulation EPHB2 PDLIM7 22649786 940150 Positive_regulation EPHB2 PDLIM7 22880054 2673933 Positive_regulation EPHB2 PDLIM7 24759913 2957826 Positive_regulation EPHB2 PEA15 19917132 385839 Positive_regulation EPHB2 PEA15 19917132 385848 Positive_regulation EPHB2 PEA15 22813067 380994 Positive_regulation EPHB2 PEBP1 17958888 1242796 Positive_regulation EPHB2 PEBP1 22860010 2670752 Positive_regulation EPHB2 PEBP1 25147739 413828 Positive_regulation EPHB2 PECAM1 12177047 1286330 Positive_regulation EPHB2 PER2 25268972 3011832 Positive_regulation EPHB2 PFN1 21049052 2480581 Positive_regulation EPHB2 PFN1 21049052 2480603 Positive_regulation EPHB2 PFN2 21049052 2480582 Positive_regulation EPHB2 PFN2 21049052 2480604 Positive_regulation EPHB2 PFN3 21049052 2480579 Positive_regulation EPHB2 PFN3 21049052 2480601 Positive_regulation EPHB2 PFN4 21049052 2480580 Positive_regulation EPHB2 PFN4 21049052 2480602 Positive_regulation EPHB2 PGC 17987121 2380292 Positive_regulation EPHB2 PGF 11914123 276467 Positive_regulation EPHB2 PGF 11914123 276512 Positive_regulation EPHB2 PGF 11914123 276516 Positive_regulation EPHB2 PGF 20551949 434991 Positive_regulation EPHB2 PGF 22967907 1506556 Positive_regulation EPHB2 PGF 22967907 1506596 Positive_regulation EPHB2 PGP 21249198 2493284 Positive_regulation EPHB2 PHB 24096434 93457 Positive_regulation EPHB2 PHB 24568222 1872214 Positive_regulation EPHB2 PHB 24568222 1872215 Positive_regulation EPHB2 PHKA2 11149924 1266995 Positive_regulation EPHB2 PHKA2 11149924 1266997 Positive_regulation EPHB2 PHKA2 16606672 1540052 Positive_regulation EPHB2 PHKA2 18404483 3087917 Positive_regulation EPHB2 PHKA2 18404483 3088149 Positive_regulation EPHB2 PHLDA1 18597688 251130 Positive_regulation EPHB2 PHLDA1 18597688 251131 Positive_regulation EPHB2 PHLDA1 18597688 251144 Positive_regulation EPHB2 PHLDA1 18597688 251147 Positive_regulation EPHB2 PHLDA1 22961087 724579 Positive_regulation EPHB2 PI3 11435472 1519606 Positive_regulation EPHB2 PI3 11435472 1519607 Positive_regulation EPHB2 PI3 12556972 422147 Positive_regulation EPHB2 PI3 18004277 1902483 Positive_regulation EPHB2 PI3 18404483 3087817 Positive_regulation EPHB2 PI3 19804648 1835330 Positive_regulation EPHB2 PI3 20544025 2452607 Positive_regulation EPHB2 PI3 21401944 304787 Positive_regulation EPHB2 PI3 21779235 928011 Positive_regulation EPHB2 PI3 22984590 2689299 Positive_regulation EPHB2 PI3 23216800 2113639 Positive_regulation EPHB2 PI3 23320105 2739638 Positive_regulation EPHB2 PI3 23320105 2739645 Positive_regulation EPHB2 PI3 23971004 946135 Positive_regulation EPHB2 PI3 24520260 844112 Positive_regulation EPHB2 PIAS4 24002598 441801 Positive_regulation EPHB2 PIK3C3 24917448 3216324 Positive_regulation EPHB2 PIK3CA 12482999 1633917 Positive_regulation EPHB2 PIK3CA 14997210 424378 Positive_regulation EPHB2 PIK3CA 15149544 241502 Positive_regulation EPHB2 PIK3CA 16103225 1323252 Positive_regulation EPHB2 PIK3CA 16255777 1695458 Positive_regulation EPHB2 PIK3CA 17722974 2289465 Positive_regulation EPHB2 PIK3CA 18159242 2381544 Positive_regulation EPHB2 PIK3CA 18224247 3373 Positive_regulation EPHB2 PIK3CA 18404465 3087723 Positive_regulation EPHB2 PIK3CA 19804648 1835331 Positive_regulation EPHB2 PIK3CA 19878579 283639 Positive_regulation EPHB2 PIK3CA 20472883 2007906 Positive_regulation EPHB2 PIK3CA 21048967 2480328 Positive_regulation EPHB2 PIK3CA 21209852 2491375 Positive_regulation EPHB2 PIK3CA 21209852 2491376 Positive_regulation EPHB2 PIK3CA 21209852 2491450 Positive_regulation EPHB2 PIK3CA 21278786 2137754 Positive_regulation EPHB2 PIK3CA 21311715 2502479 Positive_regulation EPHB2 PIK3CA 21629786 2525660 Positive_regulation EPHB2 PIK3CA 21980400 2560298 Positive_regulation EPHB2 PIK3CA 22438844 951435 Positive_regulation EPHB2 PIK3CA 22649371 874791 Positive_regulation EPHB2 PIK3CA 22649371 874951 Positive_regulation EPHB2 PIK3CA 22649371 874952 Positive_regulation EPHB2 PIK3CA 22745786 2656472 Positive_regulation EPHB2 PIK3CA 22879882 2672812 Positive_regulation EPHB2 PIK3CA 22879882 2672830 Positive_regulation EPHB2 PIK3CA 22879882 2672832 Positive_regulation EPHB2 PIK3CA 22879882 2672834 Positive_regulation EPHB2 PIK3CA 22879882 2672869 Positive_regulation EPHB2 PIK3CA 23162692 3131685 Positive_regulation EPHB2 PIK3CA 23292489 1886129 Positive_regulation EPHB2 PIK3CA 23308188 2738680 Positive_regulation EPHB2 PIK3CA 23345981 3177036 Positive_regulation EPHB2 PIK3CA 23418602 2754850 Positive_regulation EPHB2 PIK3CA 23437362 2756703 Positive_regulation EPHB2 PIK3CA 23459844 942319 Positive_regulation EPHB2 PIK3CA 23505453 2766115 Positive_regulation EPHB2 PIK3CA 23591770 3135517 Positive_regulation EPHB2 PIK3CA 23680019 3215592 Positive_regulation EPHB2 PIK3CA 24071646 566647 Positive_regulation EPHB2 PIK3CA 24272818 2185591 Positive_regulation EPHB2 PIK3CA 24304619 809466 Positive_regulation EPHB2 PIK3CA 24575365 20594 Positive_regulation EPHB2 PIK3CA 24586357 2924399 Positive_regulation EPHB2 PIK3CA 24795729 912597 Positive_regulation EPHB2 PIK3CA 25099740 1651938 Positive_regulation EPHB2 PIK3CA 25258648 1240856 Positive_regulation EPHB2 PIK3CA 25421240 1135028 Positive_regulation EPHB2 PIK3CA 25452812 845460 Positive_regulation EPHB2 PIK3R1 12482999 1633918 Positive_regulation EPHB2 PIK3R1 14997210 424379 Positive_regulation EPHB2 PIK3R1 15149544 241503 Positive_regulation EPHB2 PIK3R1 16103225 1323253 Positive_regulation EPHB2 PIK3R1 16255777 1695459 Positive_regulation EPHB2 PIK3R1 17722974 2289466 Positive_regulation EPHB2 PIK3R1 18159242 2381545 Positive_regulation EPHB2 PIK3R1 18224247 3374 Positive_regulation EPHB2 PIK3R1 18404465 3087724 Positive_regulation EPHB2 PIK3R1 19804648 1835332 Positive_regulation EPHB2 PIK3R1 19878579 283640 Positive_regulation EPHB2 PIK3R1 20472883 2007907 Positive_regulation EPHB2 PIK3R1 21048967 2480329 Positive_regulation EPHB2 PIK3R1 21209852 2491377 Positive_regulation EPHB2 PIK3R1 21209852 2491378 Positive_regulation EPHB2 PIK3R1 21209852 2491451 Positive_regulation EPHB2 PIK3R1 21278786 2137755 Positive_regulation EPHB2 PIK3R1 21311715 2502480 Positive_regulation EPHB2 PIK3R1 21629786 2525661 Positive_regulation EPHB2 PIK3R1 21980400 2560299 Positive_regulation EPHB2 PIK3R1 22438844 951436 Positive_regulation EPHB2 PIK3R1 22649371 874792 Positive_regulation EPHB2 PIK3R1 22649371 874953 Positive_regulation EPHB2 PIK3R1 22649371 874954 Positive_regulation EPHB2 PIK3R1 22745786 2656473 Positive_regulation EPHB2 PIK3R1 22879882 2672813 Positive_regulation EPHB2 PIK3R1 22879882 2672831 Positive_regulation EPHB2 PIK3R1 22879882 2672833 Positive_regulation EPHB2 PIK3R1 22879882 2672835 Positive_regulation EPHB2 PIK3R1 22879882 2672870 Positive_regulation EPHB2 PIK3R1 23162692 3131686 Positive_regulation EPHB2 PIK3R1 23292489 1886130 Positive_regulation EPHB2 PIK3R1 23308188 2738681 Positive_regulation EPHB2 PIK3R1 23345981 3177037 Positive_regulation EPHB2 PIK3R1 23418602 2754851 Positive_regulation EPHB2 PIK3R1 23437362 2756704 Positive_regulation EPHB2 PIK3R1 23459844 942320 Positive_regulation EPHB2 PIK3R1 23505453 2766116 Positive_regulation EPHB2 PIK3R1 23591770 3135518 Positive_regulation EPHB2 PIK3R1 23680019 3215593 Positive_regulation EPHB2 PIK3R1 24071646 566648 Positive_regulation EPHB2 PIK3R1 24272818 2185592 Positive_regulation EPHB2 PIK3R1 24304619 809467 Positive_regulation EPHB2 PIK3R1 24575365 20595 Positive_regulation EPHB2 PIK3R1 24586357 2924400 Positive_regulation EPHB2 PIK3R1 24795729 912598 Positive_regulation EPHB2 PIK3R1 25258648 1240857 Positive_regulation EPHB2 PIK3R1 25421240 1135029 Positive_regulation EPHB2 PIK3R1 25452812 845461 Positive_regulation EPHB2 PIK3R4 24917448 3216325 Positive_regulation EPHB2 PIM1 21860423 2142193 Positive_regulation EPHB2 PIM1 23455493 2182255 Positive_regulation EPHB2 PIP 22817771 471854 Positive_regulation EPHB2 PKD1 21993393 553283 Positive_regulation EPHB2 PKD2 21993393 553284 Positive_regulation EPHB2 PKD3 21993393 553285 Positive_regulation EPHB2 PKN1 12952943 1296778 Positive_regulation EPHB2 PKN1 12952943 1296800 Positive_regulation EPHB2 PKN1 19317917 1005825 Positive_regulation EPHB2 PKN1 19317917 1005887 Positive_regulation EPHB2 PKN1 23162740 589255 Positive_regulation EPHB2 PKN1 24324645 2890939 Positive_regulation EPHB2 PLAU 10402467 1248038 Positive_regulation EPHB2 PLAU 10402467 1248058 Positive_regulation EPHB2 PLAU 10402467 1248059 Positive_regulation EPHB2 PLAU 11266465 1269097 Positive_regulation EPHB2 PLAU 11266465 1269098 Positive_regulation EPHB2 PLAU 11266465 1269099 Positive_regulation EPHB2 PLAU 11266465 1269106 Positive_regulation EPHB2 PLAU 11266465 1269111 Positive_regulation EPHB2 PLAU 11266465 1269122 Positive_regulation EPHB2 PLAU 11266465 1269126 Positive_regulation EPHB2 PLAU 12865932 422931 Positive_regulation EPHB2 PLAU 12865932 422932 Positive_regulation EPHB2 PLAU 12865932 422933 Positive_regulation EPHB2 PLAU 12865932 422946 Positive_regulation EPHB2 PLAU 12865932 422955 Positive_regulation EPHB2 PLAU 12865932 422956 Positive_regulation EPHB2 PLAU 12865932 422957 Positive_regulation EPHB2 PLAU 12865932 422964 Positive_regulation EPHB2 PLAU 16504015 278976 Positive_regulation EPHB2 PLAU 20868520 1859508 Positive_regulation EPHB2 PLAU 21798065 1505382 Positive_regulation EPHB2 PLAU 24971065 965305 Positive_regulation EPHB2 PLAUR 10508858 1250914 Positive_regulation EPHB2 PLAUR 10508858 1250919 Positive_regulation EPHB2 PLAUR 12865932 422934 Positive_regulation EPHB2 PLAUR 12865932 422935 Positive_regulation EPHB2 PLAUR 12865932 422936 Positive_regulation EPHB2 PLAUR 12865932 422947 Positive_regulation EPHB2 PLAUR 16504015 278977 Positive_regulation EPHB2 PLAUR 19242538 2406261 Positive_regulation EPHB2 PLAUR 19242538 2406264 Positive_regulation EPHB2 PLAUR 19483730 2125492 Positive_regulation EPHB2 PLAUR 20644732 2456136 Positive_regulation EPHB2 PLAUR 21798065 1505383 Positive_regulation EPHB2 PLAUR 21798065 1505384 Positive_regulation EPHB2 PLAUR 21998707 2562077 Positive_regulation EPHB2 PLAUR 23076139 518465 Positive_regulation EPHB2 PLAUR 23549262 1104716 Positive_regulation EPHB2 PLAUR 23797476 2156898 Positive_regulation EPHB2 PLAUR 23797476 2156911 Positive_regulation EPHB2 PLD1 20231899 2443186 Positive_regulation EPHB2 PLD1 20231899 2443253 Positive_regulation EPHB2 PLD1 20231899 2443286 Positive_regulation EPHB2 PLD1 20231899 2443449 Positive_regulation EPHB2 PLD1 20231899 2443462 Positive_regulation EPHB2 PLD1 20231899 2443463 Positive_regulation EPHB2 PLD1 20462959 1776095 Positive_regulation EPHB2 PLD1 20981256 1217314 Positive_regulation EPHB2 PLD1 21254404 775803 Positive_regulation EPHB2 PLD1 23989060 839921 Positive_regulation EPHB2 PLD2 20231899 2443187 Positive_regulation EPHB2 PLD2 20231899 2443254 Positive_regulation EPHB2 PLD2 20462959 1776096 Positive_regulation EPHB2 PLD2 20981256 1217315 Positive_regulation EPHB2 PLD2 21254404 775804 Positive_regulation EPHB2 PLD2 23989060 839922 Positive_regulation EPHB2 PLD3 20231899 2443182 Positive_regulation EPHB2 PLD3 20231899 2443249 Positive_regulation EPHB2 PLD3 20462959 1776090 Positive_regulation EPHB2 PLD3 20981256 1217309 Positive_regulation EPHB2 PLD3 21254404 775799 Positive_regulation EPHB2 PLD3 23989060 839917 Positive_regulation EPHB2 PLD4 20231899 2443183 Positive_regulation EPHB2 PLD4 20231899 2443250 Positive_regulation EPHB2 PLD4 20462959 1776091 Positive_regulation EPHB2 PLD4 20981256 1217310 Positive_regulation EPHB2 PLD4 21254404 775800 Positive_regulation EPHB2 PLD4 23989060 839918 Positive_regulation EPHB2 PLD5 20231899 2443184 Positive_regulation EPHB2 PLD5 20231899 2443251 Positive_regulation EPHB2 PLD5 20462959 1776092 Positive_regulation EPHB2 PLD5 20981256 1217311 Positive_regulation EPHB2 PLD5 21254404 775801 Positive_regulation EPHB2 PLD5 23989060 839919 Positive_regulation EPHB2 PLD6 20231899 2443185 Positive_regulation EPHB2 PLD6 20231899 2443252 Positive_regulation EPHB2 PLD6 20462959 1776093 Positive_regulation EPHB2 PLD6 20981256 1217312 Positive_regulation EPHB2 PLD6 21254404 775802 Positive_regulation EPHB2 PLD6 23989060 839920 Positive_regulation EPHB2 PLEC 24015256 2842470 Positive_regulation EPHB2 PLEC 24499192 367680 Positive_regulation EPHB2 PLG 23875077 1615815 Positive_regulation EPHB2 PLG 23984088 1150958 Positive_regulation EPHB2 PLXNA4 21098092 1561610 Positive_regulation EPHB2 PNKD 18931684 1960475 Positive_regulation EPHB2 POLDIP2 20565717 119143 Positive_regulation EPHB2 POLDIP2 22294469 135317 Positive_regulation EPHB2 POLDIP2 22966240 636916 Positive_regulation EPHB2 POLDIP2 23389627 1811955 Positive_regulation EPHB2 PON1 24722398 3066679 Positive_regulation EPHB2 PON1 24722398 3066680 Positive_regulation EPHB2 POT1 15026815 424435 Positive_regulation EPHB2 POT1 19137382 621165 Positive_regulation EPHB2 POT1 19804630 401973 Positive_regulation EPHB2 POT1 25118589 1944696 Positive_regulation EPHB2 POT1 25629002 949881 Positive_regulation EPHB2 POU2F1 24717932 1023908 Positive_regulation EPHB2 POU2F1 24717932 1023922 Positive_regulation EPHB2 POU2F1 24717932 1023940 Positive_regulation EPHB2 POU5F1 24643025 2935529 Positive_regulation EPHB2 POU5F1 24643025 2935551 Positive_regulation EPHB2 POU5F1 24643025 2935552 Positive_regulation EPHB2 POU5F1 24643025 2935563 Positive_regulation EPHB2 PPM1A 22384250 2607579 Positive_regulation EPHB2 PPM1A 23903585 3136540 Positive_regulation EPHB2 PPM1A 23903585 3136555 Positive_regulation EPHB2 PPM1D 23369183 472834 Positive_regulation EPHB2 PPP1R1B 21808606 933208 Positive_regulation EPHB2 PPP1R1B 21863137 933509 Positive_regulation EPHB2 PPP1R1B 22590645 2642373 Positive_regulation EPHB2 PPP2CA 17875674 1547023 Positive_regulation EPHB2 PPP2CA 22739989 556417 Positive_regulation EPHB2 PPP2CA 24860782 947847 Positive_regulation EPHB2 PPP2CA 24885237 1233650 Positive_regulation EPHB2 PPP2CA 24937142 851355 Positive_regulation EPHB2 PPP2R1A 17875674 1547024 Positive_regulation EPHB2 PPP2R1A 22739989 556418 Positive_regulation EPHB2 PPP2R1A 24860782 947848 Positive_regulation EPHB2 PPP2R1A 24885237 1233651 Positive_regulation EPHB2 PPP2R1A 24937142 851356 Positive_regulation EPHB2 PPP2R2B 17875674 1547025 Positive_regulation EPHB2 PPP2R2B 22739989 556419 Positive_regulation EPHB2 PPP2R2B 24860782 947849 Positive_regulation EPHB2 PPP2R2B 24885237 1233652 Positive_regulation EPHB2 PPP2R2B 24937142 851357 Positive_regulation EPHB2 PPP3CA 14623863 1301027 Positive_regulation EPHB2 PPP3CA 14624253 2255190 Positive_regulation EPHB2 PPP3CB 14623863 1301028 Positive_regulation EPHB2 PPP3CC 14623863 1301029 Positive_regulation EPHB2 PPP3R1 14624253 2255191 Positive_regulation EPHB2 PPP5C 20870566 794146 Positive_regulation EPHB2 PRDX2 23951179 2833637 Positive_regulation EPHB2 PRDX2 23951179 2833643 Positive_regulation EPHB2 PRKAA1 20231899 2443206 Positive_regulation EPHB2 PRKAA1 20231899 2443287 Positive_regulation EPHB2 PRKAA1 20231899 2443464 Positive_regulation EPHB2 PRKAA1 22269797 1898976 Positive_regulation EPHB2 PRKAA1 22511782 1203218 Positive_regulation EPHB2 PRKAA1 22751115 2147847 Positive_regulation EPHB2 PRKAA1 24710474 618078 Positive_regulation EPHB2 PRKAA2 20231899 2443207 Positive_regulation EPHB2 PRKAA2 20231899 2443288 Positive_regulation EPHB2 PRKAA2 20231899 2443465 Positive_regulation EPHB2 PRKAA2 22269797 1898977 Positive_regulation EPHB2 PRKAA2 22511782 1203219 Positive_regulation EPHB2 PRKAA2 22751115 2147848 Positive_regulation EPHB2 PRKAA2 24710474 618079 Positive_regulation EPHB2 PRKAB1 20231899 2443208 Positive_regulation EPHB2 PRKAB1 20231899 2443289 Positive_regulation EPHB2 PRKAB1 20231899 2443466 Positive_regulation EPHB2 PRKAB1 22269797 1898978 Positive_regulation EPHB2 PRKAB1 22511782 1203220 Positive_regulation EPHB2 PRKAB1 22751115 2147849 Positive_regulation EPHB2 PRKAB1 24710474 618080 Positive_regulation EPHB2 PRKAB2 20231899 2443209 Positive_regulation EPHB2 PRKAB2 20231899 2443290 Positive_regulation EPHB2 PRKAB2 20231899 2443467 Positive_regulation EPHB2 PRKAB2 22269797 1898979 Positive_regulation EPHB2 PRKAB2 22511782 1203221 Positive_regulation EPHB2 PRKAB2 22751115 2147850 Positive_regulation EPHB2 PRKAB2 24710474 618081 Positive_regulation EPHB2 PRKACB 16091148 524439 Positive_regulation EPHB2 PRKACB 19419557 1891215 Positive_regulation EPHB2 PRKACB 19558693 253700 Positive_regulation EPHB2 PRKACB 19664265 1897299 Positive_regulation EPHB2 PRKACB 21595896 1229199 Positive_regulation EPHB2 PRKACB 21647396 858430 Positive_regulation EPHB2 PRKACB 21808606 933209 Positive_regulation EPHB2 PRKACB 22666216 876707 Positive_regulation EPHB2 PRKACB 22666216 876708 Positive_regulation EPHB2 PRKACB 22666628 2232486 Positive_regulation EPHB2 PRKACB 22675028 1803711 Positive_regulation EPHB2 PRKACB 22927932 2681075 Positive_regulation EPHB2 PRKACB 23056062 1156219 Positive_regulation EPHB2 PRKACB 24409147 953567 Positive_regulation EPHB2 PRKACB 25221471 871182 Positive_regulation EPHB2 PRKACB 25629002 949884 Positive_regulation EPHB2 PRKACG 16091148 524440 Positive_regulation EPHB2 PRKACG 19419557 1891216 Positive_regulation EPHB2 PRKACG 19558693 253701 Positive_regulation EPHB2 PRKACG 19664265 1897300 Positive_regulation EPHB2 PRKACG 21595896 1229200 Positive_regulation EPHB2 PRKACG 21647396 858431 Positive_regulation EPHB2 PRKACG 21808606 933210 Positive_regulation EPHB2 PRKACG 22666216 876709 Positive_regulation EPHB2 PRKACG 22666216 876710 Positive_regulation EPHB2 PRKACG 22666628 2232487 Positive_regulation EPHB2 PRKACG 22675028 1803712 Positive_regulation EPHB2 PRKACG 22927932 2681076 Positive_regulation EPHB2 PRKACG 23056062 1156220 Positive_regulation EPHB2 PRKACG 24409147 953568 Positive_regulation EPHB2 PRKACG 25221471 871183 Positive_regulation EPHB2 PRKACG 25629002 949885 Positive_regulation EPHB2 PRKAG1 20231899 2443210 Positive_regulation EPHB2 PRKAG1 20231899 2443291 Positive_regulation EPHB2 PRKAG1 20231899 2443468 Positive_regulation EPHB2 PRKAG1 22269797 1898980 Positive_regulation EPHB2 PRKAG1 22511782 1203222 Positive_regulation EPHB2 PRKAG1 22751115 2147851 Positive_regulation EPHB2 PRKAG1 24710474 618082 Positive_regulation EPHB2 PRKAG2 20231899 2443211 Positive_regulation EPHB2 PRKAG2 20231899 2443292 Positive_regulation EPHB2 PRKAG2 20231899 2443469 Positive_regulation EPHB2 PRKAG2 22269797 1898981 Positive_regulation EPHB2 PRKAG2 22511782 1203223 Positive_regulation EPHB2 PRKAG2 22751115 2147852 Positive_regulation EPHB2 PRKAG2 24710474 618083 Positive_regulation EPHB2 PRKAR1A 16091148 524441 Positive_regulation EPHB2 PRKAR1A 19419557 1891217 Positive_regulation EPHB2 PRKAR1A 19558693 253702 Positive_regulation EPHB2 PRKAR1A 19664265 1897301 Positive_regulation EPHB2 PRKAR1A 21595896 1229201 Positive_regulation EPHB2 PRKAR1A 21647396 858432 Positive_regulation EPHB2 PRKAR1A 21808606 933211 Positive_regulation EPHB2 PRKAR1A 22666216 876711 Positive_regulation EPHB2 PRKAR1A 22666216 876712 Positive_regulation EPHB2 PRKAR1A 22666628 2232488 Positive_regulation EPHB2 PRKAR1A 22675028 1803713 Positive_regulation EPHB2 PRKAR1A 22927932 2681077 Positive_regulation EPHB2 PRKAR1A 23056062 1156221 Positive_regulation EPHB2 PRKAR1A 24409147 953569 Positive_regulation EPHB2 PRKAR1A 25221471 871184 Positive_regulation EPHB2 PRKAR1A 25629002 949886 Positive_regulation EPHB2 PRKAR1B 16091148 524442 Positive_regulation EPHB2 PRKAR1B 19419557 1891218 Positive_regulation EPHB2 PRKAR1B 19558693 253703 Positive_regulation EPHB2 PRKAR1B 19664265 1897302 Positive_regulation EPHB2 PRKAR1B 21595896 1229202 Positive_regulation EPHB2 PRKAR1B 21647396 858433 Positive_regulation EPHB2 PRKAR1B 21808606 933212 Positive_regulation EPHB2 PRKAR1B 22666216 876713 Positive_regulation EPHB2 PRKAR1B 22666216 876714 Positive_regulation EPHB2 PRKAR1B 22666628 2232489 Positive_regulation EPHB2 PRKAR1B 22675028 1803714 Positive_regulation EPHB2 PRKAR1B 22927932 2681078 Positive_regulation EPHB2 PRKAR1B 23056062 1156222 Positive_regulation EPHB2 PRKAR1B 24409147 953570 Positive_regulation EPHB2 PRKAR1B 25221471 871185 Positive_regulation EPHB2 PRKAR1B 25629002 949887 Positive_regulation EPHB2 PRKAR2A 16091148 524443 Positive_regulation EPHB2 PRKAR2A 19419557 1891219 Positive_regulation EPHB2 PRKAR2A 19558693 253704 Positive_regulation EPHB2 PRKAR2A 19664265 1897303 Positive_regulation EPHB2 PRKAR2A 21595896 1229203 Positive_regulation EPHB2 PRKAR2A 21647396 858434 Positive_regulation EPHB2 PRKAR2A 21808606 933213 Positive_regulation EPHB2 PRKAR2A 22666216 876715 Positive_regulation EPHB2 PRKAR2A 22666216 876716 Positive_regulation EPHB2 PRKAR2A 22666628 2232490 Positive_regulation EPHB2 PRKAR2A 22675028 1803715 Positive_regulation EPHB2 PRKAR2A 22927932 2681079 Positive_regulation EPHB2 PRKAR2A 23056062 1156223 Positive_regulation EPHB2 PRKAR2A 24409147 953571 Positive_regulation EPHB2 PRKAR2A 25221471 871186 Positive_regulation EPHB2 PRKAR2A 25629002 949888 Positive_regulation EPHB2 PRKAR2B 16091148 524444 Positive_regulation EPHB2 PRKAR2B 19419557 1891220 Positive_regulation EPHB2 PRKAR2B 19558693 253705 Positive_regulation EPHB2 PRKAR2B 19664265 1897304 Positive_regulation EPHB2 PRKAR2B 21595896 1229204 Positive_regulation EPHB2 PRKAR2B 21647396 858435 Positive_regulation EPHB2 PRKAR2B 21808606 933214 Positive_regulation EPHB2 PRKAR2B 22666216 876717 Positive_regulation EPHB2 PRKAR2B 22666216 876718 Positive_regulation EPHB2 PRKAR2B 22666628 2232491 Positive_regulation EPHB2 PRKAR2B 22675028 1803716 Positive_regulation EPHB2 PRKAR2B 22927932 2681080 Positive_regulation EPHB2 PRKAR2B 23056062 1156224 Positive_regulation EPHB2 PRKAR2B 24409147 953572 Positive_regulation EPHB2 PRKAR2B 25221471 871187 Positive_regulation EPHB2 PRKAR2B 25629002 949889 Positive_regulation EPHB2 PRKCA 20444294 1228416 Positive_regulation EPHB2 PRKCA 21525937 551830 Positive_regulation EPHB2 PRKCA 23593400 2780896 Positive_regulation EPHB2 PRKCDBP 24069528 750697 Positive_regulation EPHB2 PRKCDBP 24069528 750712 Positive_regulation EPHB2 PRKCDBP 24069528 750722 Positive_regulation EPHB2 PRKCDBP 24069528 750732 Positive_regulation EPHB2 PRKCDBP 24069528 750755 Positive_regulation EPHB2 PRKCDBP 24069528 750765 Positive_regulation EPHB2 PRKCDBP 24069530 750805 Positive_regulation EPHB2 PRL 23369183 472825 Positive_regulation EPHB2 PRL 24004716 473765 Positive_regulation EPHB2 PRL 24004716 473778 Positive_regulation EPHB2 PRL 24004716 473782 Positive_regulation EPHB2 PRL 24004716 473783 Positive_regulation EPHB2 PRL 24004716 473786 Positive_regulation EPHB2 PRLR 23775766 727512 Positive_regulation EPHB2 PRTN3 22842228 1951282 Positive_regulation EPHB2 PSIP1 22046349 2566801 Positive_regulation EPHB2 PSIP1 23589723 818588 Positive_regulation EPHB2 PSIP1 23589723 818589 Positive_regulation EPHB2 PSIP1 23589723 818590 Positive_regulation EPHB2 PSIP1 23589723 818595 Positive_regulation EPHB2 PSIP1 23589723 818596 Positive_regulation EPHB2 PSIP1 23589723 818601 Positive_regulation EPHB2 PSIP1 23589723 818604 Positive_regulation EPHB2 PSMB9 24759913 2957834 Positive_regulation EPHB2 PSMG1 24098484 2856605 Positive_regulation EPHB2 PSMG1 24098484 2856606 Positive_regulation EPHB2 PTAFR 24721622 1679157 Positive_regulation EPHB2 PTAFR 24721622 1679180 Positive_regulation EPHB2 PTAFR 24721622 1679240 Positive_regulation EPHB2 PTBP1 18282094 3040945 Positive_regulation EPHB2 PTBP1 24317039 1959489 Positive_regulation EPHB2 PTBP1 24317039 1959490 Positive_regulation EPHB2 PTBP1 24317039 1959491 Positive_regulation EPHB2 PTBP1 24317039 1959516 Positive_regulation EPHB2 PTBP2 18282094 3040942 Positive_regulation EPHB2 PTBP2 24317039 1959480 Positive_regulation EPHB2 PTBP2 24317039 1959481 Positive_regulation EPHB2 PTBP2 24317039 1959482 Positive_regulation EPHB2 PTBP2 24317039 1959513 Positive_regulation EPHB2 PTCH1 24014739 787828 Positive_regulation EPHB2 PTEN 22666537 3130610 Positive_regulation EPHB2 PTEN 24957684 2232012 Positive_regulation EPHB2 PTEN 25058005 2992011 Positive_regulation EPHB2 PTEN 25058005 2992012 Positive_regulation EPHB2 PTEN 25058005 2992031 Positive_regulation EPHB2 PTEN 25301264 841041 Positive_regulation EPHB2 PTGER4 23482441 2162230 Positive_regulation EPHB2 PTGER4 24842369 1576303 Positive_regulation EPHB2 PTGER4 24842369 1576313 Positive_regulation EPHB2 PTGS2 23935760 843484 Positive_regulation EPHB2 PTGS2 24551170 2923246 Positive_regulation EPHB2 PTH 22470391 1992772 Positive_regulation EPHB2 PTH 24396730 668239 Positive_regulation EPHB2 PTH1R 23300710 2735595 Positive_regulation EPHB2 PTH1R 23300710 2735596 Positive_regulation EPHB2 PTK2 22327365 1928209 Positive_regulation EPHB2 PTK2 22761938 2659275 Positive_regulation EPHB2 PTK2 22937096 2682937 Positive_regulation EPHB2 PTK2 23873298 1108845 Positive_regulation EPHB2 PTK2 9864370 1473418 Positive_regulation EPHB2 PTK2 9864370 1473431 Positive_regulation EPHB2 PTK2B 25594051 2173954 Positive_regulation EPHB2 PTK6 22761938 2659276 Positive_regulation EPHB2 PTK6 23873298 1108846 Positive_regulation EPHB2 PTK7 22761938 2659277 Positive_regulation EPHB2 PTK7 23873298 1108847 Positive_regulation EPHB2 PTN 25380037 3023903 Positive_regulation EPHB2 PTN 25617851 3038794 Positive_regulation EPHB2 PTP4A3 23929599 781863 Positive_regulation EPHB2 PTPN1 21123182 1189579 Positive_regulation EPHB2 PTPN11 11136824 1518285 Positive_regulation EPHB2 PTPN11 11136824 1518290 Positive_regulation EPHB2 PTPN11 11956229 1280879 Positive_regulation EPHB2 PTPN11 11956229 1280932 Positive_regulation EPHB2 PTPN11 11956229 1280947 Positive_regulation EPHB2 PTPN11 11956229 1280952 Positive_regulation EPHB2 PTPN11 12177047 1286335 Positive_regulation EPHB2 PTPN11 17211494 1083629 Positive_regulation EPHB2 PTPN11 17616983 2289423 Positive_regulation EPHB2 PTPN11 18335055 2387151 Positive_regulation EPHB2 PTPN11 19737390 526079 Positive_regulation EPHB2 PTPN11 21552417 1057129 Positive_regulation EPHB2 PTPN11 21829671 2542280 Positive_regulation EPHB2 PTPN11 22216034 22196 Positive_regulation EPHB2 PTPN11 22235335 2585900 Positive_regulation EPHB2 PTPN11 22777356 2147991 Positive_regulation EPHB2 PTPN11 22777356 2147998 Positive_regulation EPHB2 PTPN11 22777356 2147999 Positive_regulation EPHB2 PTPN11 22777356 2148005 Positive_regulation EPHB2 PTPN11 22777356 2148020 Positive_regulation EPHB2 PTPN11 23165317 2181651 Positive_regulation EPHB2 PTPN11 23308070 937577 Positive_regulation EPHB2 PTPN11 23863940 1990721 Positive_regulation EPHB2 PTPN11 25003010 3092926 Positive_regulation EPHB2 PTPN11 25003010 3092930 Positive_regulation EPHB2 PTPN11 25220640 19696 Positive_regulation EPHB2 PTPN11 25364578 478481 Positive_regulation EPHB2 PTPN11 25522349 2301583 Positive_regulation EPHB2 PTPN11 25535838 762892 Positive_regulation EPHB2 PTPN13 19734941 2126773 Positive_regulation EPHB2 PTPN13 PMC4261712 1049457 Positive_regulation EPHB2 PTPN22 23991106 2840936 Positive_regulation EPHB2 PTPN22 23991106 2840944 Positive_regulation EPHB2 PTPN22 24131623 270096 Positive_regulation EPHB2 PTPRR 17224080 1645038 Positive_regulation EPHB2 PTX3 12821648 1293208 Positive_regulation EPHB2 PTX3 15753205 1534824 Positive_regulation EPHB2 PTX3 22447027 1956998 Positive_regulation EPHB2 PTX3 24069221 2852208 Positive_regulation EPHB2 PTX3 24743392 2955199 Positive_regulation EPHB2 PTX4 12821648 1293205 Positive_regulation EPHB2 PTX4 15753205 1534823 Positive_regulation EPHB2 PTX4 22447027 1956997 Positive_regulation EPHB2 PTX4 24069221 2852207 Positive_regulation EPHB2 PTX4 24743392 2955197 Positive_regulation EPHB2 PVR 16216929 1324755 Positive_regulation EPHB2 PXN 19885391 2269668 Positive_regulation EPHB2 PXN 22028449 788580 Positive_regulation EPHB2 PXN 22028449 788597 Positive_regulation EPHB2 RAB10 22852067 3184173 Positive_regulation EPHB2 RAB11A 23535298 543134 Positive_regulation EPHB2 RAB11A 23535298 543142 Positive_regulation EPHB2 RAB12 22852067 3184172 Positive_regulation EPHB2 RAB13 22852067 3184174 Positive_regulation EPHB2 RAB14 22852067 3184161 Positive_regulation EPHB2 RAB15 22852067 3184168 Positive_regulation EPHB2 RAB17 22852067 3184160 Positive_regulation EPHB2 RAB18 22852067 3184156 Positive_regulation EPHB2 RAB19 22852067 3184166 Positive_regulation EPHB2 RAB20 22852067 3184163 Positive_regulation EPHB2 RAB21 22852067 3184164 Positive_regulation EPHB2 RAB23 22852067 3184158 Positive_regulation EPHB2 RAB24 22852067 3184175 Positive_regulation EPHB2 RAB25 22852067 3184162 Positive_regulation EPHB2 RAB26 22852067 3184157 Positive_regulation EPHB2 RAB28 22852067 3184176 Positive_regulation EPHB2 RAB30 22852067 3184177 Positive_regulation EPHB2 RAB31 22852067 3184178 Positive_regulation EPHB2 RAB32 22852067 3184179 Positive_regulation EPHB2 RAB34 22852067 3184159 Positive_regulation EPHB2 RAB35 22852067 3184180 Positive_regulation EPHB2 RAB36 22852067 3184181 Positive_regulation EPHB2 RAB37 22852067 3184171 Positive_regulation EPHB2 RAB38 22852067 3184182 Positive_regulation EPHB2 RAB41 22852067 3184165 Positive_regulation EPHB2 RAB42 22852067 3184170 Positive_regulation EPHB2 RAB43 22852067 3184167 Positive_regulation EPHB2 RAB44 22852067 3184169 Positive_regulation EPHB2 RAB7A 21151572 2485165 Positive_regulation EPHB2 RAC1 11581314 1521053 Positive_regulation EPHB2 RAC1 11980921 1282392 Positive_regulation EPHB2 RAC1 16606672 1540053 Positive_regulation EPHB2 RAC1 19015320 1361482 Positive_regulation EPHB2 RAC1 22511753 1203203 Positive_regulation EPHB2 RAC1 22701712 2652227 Positive_regulation EPHB2 RAC1 22842228 1951283 Positive_regulation EPHB2 RAC1 23006971 2181056 Positive_regulation EPHB2 RAC1 23049742 2699242 Positive_regulation EPHB2 RAC1 23389627 1811788 Positive_regulation EPHB2 RAC1 23389627 1811789 Positive_regulation EPHB2 RAC1 23389627 1811790 Positive_regulation EPHB2 RAC1 23389627 1811883 Positive_regulation EPHB2 RAC1 23986484 1487161 Positive_regulation EPHB2 RAC1 24722482 840658 Positive_regulation EPHB2 RAC2 11581314 1521054 Positive_regulation EPHB2 RAC2 11980921 1282393 Positive_regulation EPHB2 RAC2 16606672 1540054 Positive_regulation EPHB2 RAC2 22511753 1203204 Positive_regulation EPHB2 RAC2 23006971 2181057 Positive_regulation EPHB2 RAC2 23389627 1811791 Positive_regulation EPHB2 RAC2 23389627 1811792 Positive_regulation EPHB2 RAC2 23389627 1811793 Positive_regulation EPHB2 RAC2 23389627 1811884 Positive_regulation EPHB2 RAC2 23986484 1487162 Positive_regulation EPHB2 RAC3 11581314 1521055 Positive_regulation EPHB2 RAC3 11980921 1282394 Positive_regulation EPHB2 RAC3 16606672 1540055 Positive_regulation EPHB2 RAC3 22511753 1203205 Positive_regulation EPHB2 RAC3 23006971 2181058 Positive_regulation EPHB2 RAC3 23389627 1811794 Positive_regulation EPHB2 RAC3 23389627 1811795 Positive_regulation EPHB2 RAC3 23389627 1811796 Positive_regulation EPHB2 RAC3 23389627 1811885 Positive_regulation EPHB2 RAC3 23986484 1487163 Positive_regulation EPHB2 RAD1 24416349 2907648 Positive_regulation EPHB2 RAD17 24416349 2907649 Positive_regulation EPHB2 RAD18 24416349 2907640 Positive_regulation EPHB2 RAD21 24416349 2907650 Positive_regulation EPHB2 RAD50 15026815 424438 Positive_regulation EPHB2 RAD50 16787538 3096300 Positive_regulation EPHB2 RAD50 19137382 621171 Positive_regulation EPHB2 RAD50 19804630 401938 Positive_regulation EPHB2 RAD50 19804630 401979 Positive_regulation EPHB2 RAD50 23758320 151623 Positive_regulation EPHB2 RAD50 23758320 151641 Positive_regulation EPHB2 RAD50 24416349 2907651 Positive_regulation EPHB2 RAD50 25118589 1944699 Positive_regulation EPHB2 RAD50 25629002 949890 Positive_regulation EPHB2 RAD51 22211105 1058743 Positive_regulation EPHB2 RAD51 24416349 2907652 Positive_regulation EPHB2 RAD52 24416349 2907653 Positive_regulation EPHB2 RAF1 10725339 1256861 Positive_regulation EPHB2 RAF1 11157055 1518381 Positive_regulation EPHB2 RAF1 11157055 1518411 Positive_regulation EPHB2 RAF1 11157988 1267369 Positive_regulation EPHB2 RAF1 11157988 1267375 Positive_regulation EPHB2 RAF1 16115325 1036186 Positive_regulation EPHB2 RAF1 17214889 580968 Positive_regulation EPHB2 RAF1 18335053 2387025 Positive_regulation EPHB2 RAF1 18355401 1646237 Positive_regulation EPHB2 RAF1 18404483 3087918 Positive_regulation EPHB2 RAF1 18404483 3088080 Positive_regulation EPHB2 RAF1 20711231 2133607 Positive_regulation EPHB2 RAF1 21860067 2176438 Positive_regulation EPHB2 RAF1 22384111 2605918 Positive_regulation EPHB2 RAF1 22384111 2605919 Positive_regulation EPHB2 RAF1 23085539 2181415 Positive_regulation EPHB2 RAF1 23118896 2711960 Positive_regulation EPHB2 RAF1 23209424 2340105 Positive_regulation EPHB2 RAF1 23412386 559913 Positive_regulation EPHB2 RAF1 23554919 2773846 Positive_regulation EPHB2 RAF1 23690850 818989 Positive_regulation EPHB2 RAF1 23970928 822293 Positive_regulation EPHB2 RAF1 24667437 2938714 Positive_regulation EPHB2 RAF1 25277181 2203052 Positive_regulation EPHB2 RANBP9 23118896 2712042 Positive_regulation EPHB2 RAPGEF2 17724123 1344125 Positive_regulation EPHB2 RASA1 24937142 851408 Positive_regulation EPHB2 RASD2 16507103 225498 Positive_regulation EPHB2 RASGRF1 22028687 860511 Positive_regulation EPHB2 RASGRF1 22232579 860802 Positive_regulation EPHB2 RASGRF1 24499932 2299568 Positive_regulation EPHB2 RASGRF2 22028687 860512 Positive_regulation EPHB2 RASGRF2 22232579 860803 Positive_regulation EPHB2 RASGRP1 17190838 1543854 Positive_regulation EPHB2 RASGRP1 17190838 1543886 Positive_regulation EPHB2 RASGRP1 21441934 1955194 Positive_regulation EPHB2 RASGRP1 21441934 1955195 Positive_regulation EPHB2 RASGRP1 21441934 1955196 Positive_regulation EPHB2 RASGRP1 21441934 1955197 Positive_regulation EPHB2 RASGRP1 21441934 1955279 Positive_regulation EPHB2 RASGRP1 22028687 860513 Positive_regulation EPHB2 RASGRP1 22719950 2653885 Positive_regulation EPHB2 RASGRP1 22719950 2653886 Positive_regulation EPHB2 RASGRP1 22719950 2653888 Positive_regulation EPHB2 RASGRP1 22719950 2653890 Positive_regulation EPHB2 RASGRP1 23308188 2738591 Positive_regulation EPHB2 RASGRP1 23308188 2738596 Positive_regulation EPHB2 RASGRP1 23308188 2738613 Positive_regulation EPHB2 RASGRP1 23308188 2738614 Positive_regulation EPHB2 RASGRP1 23308188 2738649 Positive_regulation EPHB2 RASGRP1 23308188 2738682 Positive_regulation EPHB2 RASGRP1 23308188 2738691 Positive_regulation EPHB2 RASGRP1 24027568 908795 Positive_regulation EPHB2 RASGRP1 24027568 908796 Positive_regulation EPHB2 RASGRP1 24027568 908849 Positive_regulation EPHB2 RASGRP1 24336796 752218 Positive_regulation EPHB2 RASGRP1 25118589 1945193 Positive_regulation EPHB2 RASGRP2 21441934 1955198 Positive_regulation EPHB2 RASGRP2 21441934 1955280 Positive_regulation EPHB2 RASGRP2 24027568 908797 Positive_regulation EPHB2 RASGRP2 24027568 908850 Positive_regulation EPHB2 RASGRP2 25118589 1945194 Positive_regulation EPHB2 RASGRP3 21441934 1955190 Positive_regulation EPHB2 RASGRP3 21441934 1955277 Positive_regulation EPHB2 RASGRP3 22640752 125999 Positive_regulation EPHB2 RASGRP3 23308188 2738610 Positive_regulation EPHB2 RASGRP3 23308188 2738647 Positive_regulation EPHB2 RASGRP3 24027568 908793 Positive_regulation EPHB2 RASGRP3 24027568 908847 Positive_regulation EPHB2 RASGRP3 24779681 1874150 Positive_regulation EPHB2 RASGRP3 25118589 1945191 Positive_regulation EPHB2 RASGRP4 21441934 1955193 Positive_regulation EPHB2 RASGRP4 21441934 1955278 Positive_regulation EPHB2 RASGRP4 24027568 908794 Positive_regulation EPHB2 RASGRP4 24027568 908848 Positive_regulation EPHB2 RASGRP4 25118589 1945192 Positive_regulation EPHB2 RASSF5 23847621 908163 Positive_regulation EPHB2 RBBP4 16262446 2258787 Positive_regulation EPHB2 RBBP4 23166712 2718722 Positive_regulation EPHB2 RBBP7 16262446 2258788 Positive_regulation EPHB2 RBBP7 23166712 2718723 Positive_regulation EPHB2 RBMS1 25144469 1736708 Positive_regulation EPHB2 RBP4 24604418 1886297 Positive_regulation EPHB2 REL 15606917 1734101 Positive_regulation EPHB2 REL 20562914 2132664 Positive_regulation EPHB2 REL 20562914 2132689 Positive_regulation EPHB2 REL 20562914 2132736 Positive_regulation EPHB2 REL 20562914 2132758 Positive_regulation EPHB2 REL 20802521 2135470 Positive_regulation EPHB2 REL 20802521 2135471 Positive_regulation EPHB2 REL 20802521 2135472 Positive_regulation EPHB2 REL 20802521 2135511 Positive_regulation EPHB2 REL 20802521 2135522 Positive_regulation EPHB2 RELA 24983623 2985727 Positive_regulation EPHB2 RELN 23318582 610944 Positive_regulation EPHB2 RELN 23318582 610945 Positive_regulation EPHB2 RELN 23318582 610946 Positive_regulation EPHB2 RELN 23318582 610947 Positive_regulation EPHB2 RELN 23318582 610948 Positive_regulation EPHB2 RELN 23318582 610985 Positive_regulation EPHB2 RELN 23318582 610987 Positive_regulation EPHB2 RELN 23318582 610991 Positive_regulation EPHB2 RELN 23318582 611002 Positive_regulation EPHB2 RELN 23318582 611007 Positive_regulation EPHB2 RELN 23318582 611015 Positive_regulation EPHB2 RELN 23318582 611032 Positive_regulation EPHB2 RELN 23318582 611042 Positive_regulation EPHB2 RELN 23318582 611046 Positive_regulation EPHB2 RENBP 22293957 1086469 Positive_regulation EPHB2 RENBP 23348924 1101285 Positive_regulation EPHB2 RET 19649251 2422279 Positive_regulation EPHB2 RET 20386724 2271319 Positive_regulation EPHB2 RET 22751117 2147888 Positive_regulation EPHB2 RET 23527856 220399 Positive_regulation EPHB2 RET 24014739 787829 Positive_regulation EPHB2 RET 25047660 1875853 Positive_regulation EPHB2 RGS16 21610730 1933104 Positive_regulation EPHB2 RGS2 24743392 2955331 Positive_regulation EPHB2 RGS4 24743392 2955329 Positive_regulation EPHB2 RHO 23049538 3075981 Positive_regulation EPHB2 RHO 23986484 1487159 Positive_regulation EPHB2 RHO 25121106 196640 Positive_regulation EPHB2 RHOA 18404483 3087989 Positive_regulation EPHB2 RHOA 20858895 1188525 Positive_regulation EPHB2 RHOA 20858895 1188526 Positive_regulation EPHB2 RHOA 21731751 2532404 Positive_regulation EPHB2 RHOA 21731751 2532425 Positive_regulation EPHB2 RHOA 21731751 2532430 Positive_regulation EPHB2 RHOA 21731751 2532431 Positive_regulation EPHB2 RHOA 21731751 2532434 Positive_regulation EPHB2 RHOA 23251606 2729164 Positive_regulation EPHB2 RHOA 23389627 1811786 Positive_regulation EPHB2 RHOA 23389627 1811850 Positive_regulation EPHB2 RHOA 23696743 3061594 Positive_regulation EPHB2 RHOA 24478700 858786 Positive_regulation EPHB2 RHOA 24722482 840657 Positive_regulation EPHB2 RHOA 24839453 825903 Positive_regulation EPHB2 RHOA 25365944 2206700 Positive_regulation EPHB2 RHOC 15969750 1844735 Positive_regulation EPHB2 RIPK2 25090227 2995092 Positive_regulation EPHB2 RNF19A 17105652 106838 Positive_regulation EPHB2 RNF19A 22675451 2648311 Positive_regulation EPHB2 RNF19A 22933112 724435 Positive_regulation EPHB2 RNF19A 23079107 409272 Positive_regulation EPHB2 RNF19A 23389627 1811945 Positive_regulation EPHB2 RNF19A 24421891 2909277 Positive_regulation EPHB2 ROCK1 22348054 2596663 Positive_regulation EPHB2 ROCK1 24885257 290325 Positive_regulation EPHB2 ROCK1 25121106 196641 Positive_regulation EPHB2 ROCK2 22348054 2596664 Positive_regulation EPHB2 ROCK2 24885257 290326 Positive_regulation EPHB2 ROCK2 25121106 196642 Positive_regulation EPHB2 RPGR 24040053 2845368 Positive_regulation EPHB2 RPGR 24672654 1024323 Positive_regulation EPHB2 RPS10 20162012 1089316 Positive_regulation EPHB2 RPS11 20162012 1089317 Positive_regulation EPHB2 RPS12 20162012 1089318 Positive_regulation EPHB2 RPS13 20162012 1089319 Positive_regulation EPHB2 RPS14 20162012 1089320 Positive_regulation EPHB2 RPS15 20162012 1089321 Positive_regulation EPHB2 RPS16 20162012 1089322 Positive_regulation EPHB2 RPS17 20162012 1089323 Positive_regulation EPHB2 RPS18 20162012 1089324 Positive_regulation EPHB2 RPS19 20162012 1089325 Positive_regulation EPHB2 RPS2 20162012 1089326 Positive_regulation EPHB2 RPS20 20162012 1089327 Positive_regulation EPHB2 RPS21 20162012 1089328 Positive_regulation EPHB2 RPS23 20162012 1089329 Positive_regulation EPHB2 RPS24 20162012 1089330 Positive_regulation EPHB2 RPS25 20162012 1089331 Positive_regulation EPHB2 RPS26 20162012 1089332 Positive_regulation EPHB2 RPS27 20162012 1089333 Positive_regulation EPHB2 RPS28 20162012 1089334 Positive_regulation EPHB2 RPS29 20162012 1089335 Positive_regulation EPHB2 RPS3 20162012 1089336 Positive_regulation EPHB2 RPS5 20162012 1089337 Positive_regulation EPHB2 RPS6 20162012 1089338 Positive_regulation EPHB2 RPS6KA1 21219631 258385 Positive_regulation EPHB2 RPS6KA3 19917132 385847 Positive_regulation EPHB2 RPS6KA3 19917132 385864 Positive_regulation EPHB2 RPS6KA5 19956756 2432688 Positive_regulation EPHB2 RPS7 20162012 1089339 Positive_regulation EPHB2 RPS8 20162012 1089340 Positive_regulation EPHB2 RPS9 20162012 1089341 Positive_regulation EPHB2 RPTOR 22028687 860490 Positive_regulation EPHB2 RPTOR 22159814 1140670 Positive_regulation EPHB2 RPTOR 23077579 2704805 Positive_regulation EPHB2 RPTOR 24212820 498688 Positive_regulation EPHB2 RPTOR 24312679 2890610 Positive_regulation EPHB2 RPTOR 25493642 3033417 Positive_regulation EPHB2 RRAS 24705357 1034809 Positive_regulation EPHB2 RRM1 23922955 2827777 Positive_regulation EPHB2 RRM1 23922955 2827802 Positive_regulation EPHB2 RRM1 23922955 2827803 Positive_regulation EPHB2 RYR2 25093823 2995357 Positive_regulation EPHB2 S100A12 22145886 1898722 Positive_regulation EPHB2 S100A12 22145886 1898768 Positive_regulation EPHB2 S100A4 24952599 2192908 Positive_regulation EPHB2 S100A4 24952599 2192925 Positive_regulation EPHB2 S100A8 19426560 525595 Positive_regulation EPHB2 S100A8 20855497 1560220 Positive_regulation EPHB2 S100A8 20855497 1560281 Positive_regulation EPHB2 S100A8 20855497 1560285 Positive_regulation EPHB2 S100A8 21698158 2530570 Positive_regulation EPHB2 S100A8 22312430 2595187 Positive_regulation EPHB2 S100A8 24133496 909261 Positive_regulation EPHB2 S100A9 23267331 960561 Positive_regulation EPHB2 S100B 24084731 1113178 Positive_regulation EPHB2 S1PR1 21977292 1028032 Positive_regulation EPHB2 S1PR1 24798342 2189740 Positive_regulation EPHB2 S1PR1 25147438 1761253 Positive_regulation EPHB2 S1PR2 25147438 1761255 Positive_regulation EPHB2 S1PR3 25147438 1761254 Positive_regulation EPHB2 SAA1 22069745 3183791 Positive_regulation EPHB2 SAA1 22610094 1203378 Positive_regulation EPHB2 SALL1 24394804 1940280 Positive_regulation EPHB2 SALL1 24394804 1940282 Positive_regulation EPHB2 SAP18 23166712 2718717 Positive_regulation EPHB2 SAP30 23166712 2718718 Positive_regulation EPHB2 SCARNA5 23029099 2695230 Positive_regulation EPHB2 SCARNA5 23029099 2695234 Positive_regulation EPHB2 SCARNA5 23029099 2695255 Positive_regulation EPHB2 SCCPDH 22343628 1201272 Positive_regulation EPHB2 SCD 22745828 2656755 Positive_regulation EPHB2 SCG2 23586068 181428 Positive_regulation EPHB2 SCG3 23586068 181430 Positive_regulation EPHB2 SCG5 23586068 181429 Positive_regulation EPHB2 SCGB2B3P 24687958 1575555 Positive_regulation EPHB2 SCRG1 24413464 3139251 Positive_regulation EPHB2 SCRG1 24413464 3139252 Positive_regulation EPHB2 SCRIB 23359326 2744879 Positive_regulation EPHB2 SCRIB 23359326 2744899 Positive_regulation EPHB2 SDC1 23304519 1497011 Positive_regulation EPHB2 SDC2 21246051 2492964 Positive_regulation EPHB2 SDC2 25526563 1136094 Positive_regulation EPHB2 SDC4 18789696 3190784 Positive_regulation EPHB2 SDC4 21453480 855657 Positive_regulation EPHB2 SDC4 21453480 855669 Positive_regulation EPHB2 SDCBP 18794340 1552066 Positive_regulation EPHB2 SDF2 24598933 2931709 Positive_regulation EPHB2 SDF4 24598933 2931710 Positive_regulation EPHB2 SEA 22110388 1058557 Positive_regulation EPHB2 SEC13 24763048 574153 Positive_regulation EPHB2 SEC14L2 23519612 2086280 Positive_regulation EPHB2 SEC62 24763048 574154 Positive_regulation EPHB2 SEC63 24763048 574155 Positive_regulation EPHB2 SEMA4D 15210733 1310158 Positive_regulation EPHB2 SEMA4D 15210733 1310159 Positive_regulation EPHB2 SEMA4D 15210733 1310210 Positive_regulation EPHB2 SEMA4D 15210733 1310278 Positive_regulation EPHB2 SEMA4D 24841081 2971521 Positive_regulation EPHB2 SEPP1 21040561 330424 Positive_regulation EPHB2 SERPINE1 11266465 1269094 Positive_regulation EPHB2 SERPINE1 11266465 1269095 Positive_regulation EPHB2 SERPINE1 11266465 1269096 Positive_regulation EPHB2 SERPINE1 11266465 1269105 Positive_regulation EPHB2 SERPINE1 11266465 1269125 Positive_regulation EPHB2 SERPINE1 16504015 278975 Positive_regulation EPHB2 SETBP1 25025775 2989435 Positive_regulation EPHB2 SETD2 18852899 2397598 Positive_regulation EPHB2 SETD2 24069057 822967 Positive_regulation EPHB2 SETD2 25412313 579220 Positive_regulation EPHB2 SFTPB 22511974 2619163 Positive_regulation EPHB2 SFTPC 21876704 3172849 Positive_regulation EPHB2 SFTPC 22069745 3183805 Positive_regulation EPHB2 SFTPC 22127053 834078 Positive_regulation EPHB2 SFTPC 22127053 834079 Positive_regulation EPHB2 SFTPC 22127053 834106 Positive_regulation EPHB2 SGPP1 24212770 498212 Positive_regulation EPHB2 SGPP2 22610094 1203379 Positive_regulation EPHB2 SH3GL2 21849472 1793437 Positive_regulation EPHB2 SH3GL2 21849472 1793438 Positive_regulation EPHB2 SH3GL2 21849472 1793439 Positive_regulation EPHB2 SH3GL2 21849472 1793440 Positive_regulation EPHB2 SH3GL2 21849472 1793441 Positive_regulation EPHB2 SH3GL2 21849472 1793462 Positive_regulation EPHB2 SH3GL2 24736727 2953497 Positive_regulation EPHB2 SHANK3 15569713 1316947 Positive_regulation EPHB2 SHC1 15210733 1310279 Positive_regulation EPHB2 SHC1 18404483 3087899 Positive_regulation EPHB2 SHC1 18606845 1353415 Positive_regulation EPHB2 SHC1 22649417 875378 Positive_regulation EPHB2 SHC1 22662132 2647041 Positive_regulation EPHB2 SHC1 24818146 190387 Positive_regulation EPHB2 SHC1 9400937 446701 Positive_regulation EPHB2 SHC1 9763608 1604077 Positive_regulation EPHB2 SHH 22046349 2566525 Positive_regulation EPHB2 SHH 23429478 169323 Positive_regulation EPHB2 SHH 23429478 169331 Positive_regulation EPHB2 SHH 23429478 169336 Positive_regulation EPHB2 SHH 23677624 1639721 Positive_regulation EPHB2 SHH 24133411 867651 Positive_regulation EPHB2 SHH 24740159 2954536 Positive_regulation EPHB2 SHOC2 25514808 3034806 Positive_regulation EPHB2 SHOC2 25514808 3035007 Positive_regulation EPHB2 SIGMAR1 23593332 2780683 Positive_regulation EPHB2 SIK3 21860608 1038278 Positive_regulation EPHB2 SIN3A 16262446 2258784 Positive_regulation EPHB2 SIN3A 23166712 2718719 Positive_regulation EPHB2 SIRPA 21886829 2547833 Positive_regulation EPHB2 SIRT1 18320031 2384852 Positive_regulation EPHB2 SIRT1 18320031 2384853 Positive_regulation EPHB2 SIRT1 18320031 2384859 Positive_regulation EPHB2 SIRT1 21698133 2324844 Positive_regulation EPHB2 SIRT1 21698133 2324845 Positive_regulation EPHB2 SIRT1 24410795 1482544 Positive_regulation EPHB2 SIRT1 24410795 1482545 Positive_regulation EPHB2 SIRT1 24410795 1482577 Positive_regulation EPHB2 SIX1 22765220 471676 Positive_regulation EPHB2 SIX1 22765220 471677 Positive_regulation EPHB2 SIX1 22765220 471678 Positive_regulation EPHB2 SIX1 22765220 471709 Positive_regulation EPHB2 SIX1 22765220 471710 Positive_regulation EPHB2 SIX1 22765220 471728 Positive_regulation EPHB2 SIX1 22765220 471729 Positive_regulation EPHB2 SIX1 22765220 471748 Positive_regulation EPHB2 SIX1 22945933 1399925 Positive_regulation EPHB2 SKAP1 24368808 1413432 Positive_regulation EPHB2 SKP1 11435472 1519603 Positive_regulation EPHB2 SKP1 11435472 1519618 Positive_regulation EPHB2 SKP1 14981116 1531614 Positive_regulation EPHB2 SKP1 15149544 241499 Positive_regulation EPHB2 SKP1 21559359 2518497 Positive_regulation EPHB2 SKP1 23420868 2085667 Positive_regulation EPHB2 SKP1 24715976 848804 Positive_regulation EPHB2 SKP2 22279619 939657 Positive_regulation EPHB2 SLAMF1 22049305 3220619 Positive_regulation EPHB2 SLAMF7 18794340 1552068 Positive_regulation EPHB2 SLC22A3 24060241 3102144 Positive_regulation EPHB2 SLC22A3 24168056 1700788 Positive_regulation EPHB2 SLC22A3 24168056 1700820 Positive_regulation EPHB2 SLC25A16 21829637 2542219 Positive_regulation EPHB2 SLC25A16 24130864 2867421 Positive_regulation EPHB2 SLC27A5 23742646 3121878 Positive_regulation EPHB2 SLC28A1 23722537 562022 Positive_regulation EPHB2 SLC33A1 17319972 1645349 Positive_regulation EPHB2 SLC33A1 18487452 706124 Positive_regulation EPHB2 SLC33A1 18487452 706125 Positive_regulation EPHB2 SLC33A1 18487452 706126 Positive_regulation EPHB2 SLC33A1 18487452 706127 Positive_regulation EPHB2 SLC33A1 18487452 706130 Positive_regulation EPHB2 SLC33A1 18487452 706131 Positive_regulation EPHB2 SLC33A1 19246543 2042210 Positive_regulation EPHB2 SLC33A1 19254952 1165598 Positive_regulation EPHB2 SLC33A1 19254952 1165599 Positive_regulation EPHB2 SLC33A1 19254952 1165607 Positive_regulation EPHB2 SLC33A1 19254952 1165608 Positive_regulation EPHB2 SLC33A1 19254952 1165618 Positive_regulation EPHB2 SLC33A1 19254952 1165619 Positive_regulation EPHB2 SLC33A1 19254952 1165620 Positive_regulation EPHB2 SLC33A1 19254952 1165621 Positive_regulation EPHB2 SLC33A1 19254952 1165637 Positive_regulation EPHB2 SLC33A1 19254952 1165638 Positive_regulation EPHB2 SLC33A1 19254952 1165640 Positive_regulation EPHB2 SLC33A1 21167049 403507 Positive_regulation EPHB2 SLC33A1 21802439 934541 Positive_regulation EPHB2 SLC33A1 22904641 490809 Positive_regulation EPHB2 SLC33A1 23155382 2716981 Positive_regulation EPHB2 SLC33A1 24827991 2969909 Positive_regulation EPHB2 SLC33A1 24827991 2969925 Positive_regulation EPHB2 SLC33A1 24918049 853800 Positive_regulation EPHB2 SLC33A1 24982885 193511 Positive_regulation EPHB2 SLC39A6 22110740 2573119 Positive_regulation EPHB2 SLC39A6 22110740 2573126 Positive_regulation EPHB2 SLC4A1 24842369 1576312 Positive_regulation EPHB2 SLC9A1 22904641 490793 Positive_regulation EPHB2 SLC9A1 22904641 490801 Positive_regulation EPHB2 SLC9A1 22904641 490803 Positive_regulation EPHB2 SLC9A1 22904641 490814 Positive_regulation EPHB2 SLCO3A1 24945726 2981546 Positive_regulation EPHB2 SLCO3A1 24945726 2981559 Positive_regulation EPHB2 SMAD2 23696886 2795861 Positive_regulation EPHB2 SMAD3 23696886 2795862 Positive_regulation EPHB2 SMAD7 24090133 537582 Positive_regulation EPHB2 SMN2 22348054 2596634 Positive_regulation EPHB2 SNAI1 19124656 1553515 Positive_regulation EPHB2 SNAI2 14623871 1301472 Positive_regulation EPHB2 SNAI2 21829474 2541149 Positive_regulation EPHB2 SND1 24918049 853798 Positive_regulation EPHB2 SND1 24918049 853799 Positive_regulation EPHB2 SOAT1 20030801 526433 Positive_regulation EPHB2 SOCS3 24260222 2882869 Positive_regulation EPHB2 SOS1 15833106 3104972 Positive_regulation EPHB2 SOS1 18404483 3087900 Positive_regulation EPHB2 SOS1 24027568 908789 Positive_regulation EPHB2 SOS1 24027568 908790 Positive_regulation EPHB2 SOS1 25397617 3027235 Positive_regulation EPHB2 SOS1 8879209 1599179 Positive_regulation EPHB2 SOS2 15833106 3104973 Positive_regulation EPHB2 SOS2 18404483 3087901 Positive_regulation EPHB2 SOS2 24027568 908791 Positive_regulation EPHB2 SOS2 24027568 908792 Positive_regulation EPHB2 SOS2 8879209 1599180 Positive_regulation EPHB2 SOX18 23549166 543151 Positive_regulation EPHB2 SOX2 22885405 218164 Positive_regulation EPHB2 SOX2 22885405 218168 Positive_regulation EPHB2 SOX2 24643025 2935527 Positive_regulation EPHB2 SOX2 24643025 2935547 Positive_regulation EPHB2 SOX2 24643025 2935548 Positive_regulation EPHB2 SOX9 23840193 878941 Positive_regulation EPHB2 SP1 17916230 3108417 Positive_regulation EPHB2 SP1 18852899 2397597 Positive_regulation EPHB2 SP1 21829524 2541576 Positive_regulation EPHB2 SPAM1 11960552 276596 Positive_regulation EPHB2 SPAM1 11960552 276597 Positive_regulation EPHB2 SPAM1 11960552 276610 Positive_regulation EPHB2 SPAM1 11960552 276611 Positive_regulation EPHB2 SPAM1 11960552 276627 Positive_regulation EPHB2 SPHK1 16847102 1331292 Positive_regulation EPHB2 SPHK1 22563011 1033703 Positive_regulation EPHB2 SPHK1 24970177 208794 Positive_regulation EPHB2 SPN 24260485 2884578 Positive_regulation EPHB2 SPP1 20868520 1859506 Positive_regulation EPHB2 SPP1 23935934 2828584 Positive_regulation EPHB2 SPP1 23935934 2828590 Positive_regulation EPHB2 SPP1 24810160 2190001 Positive_regulation EPHB2 SPP1 24944898 1888025 Positive_regulation EPHB2 SPP1 24944898 1888041 Positive_regulation EPHB2 SPRED1 21364986 2504702 Positive_regulation EPHB2 SPRED1 25324472 32303 Positive_regulation EPHB2 SPRY1 23166773 2718914 Positive_regulation EPHB2 SPRY1 23199150 804635 Positive_regulation EPHB2 SPRY1 23469214 2763246 Positive_regulation EPHB2 SPRY1 23469214 2763267 Positive_regulation EPHB2 SPRY1 23554919 2773976 Positive_regulation EPHB2 SPRY1 24250280 2299043 Positive_regulation EPHB2 SPRY2 22666537 3130609 Positive_regulation EPHB2 SPRY2 23199150 804636 Positive_regulation EPHB2 SPRY2 24250280 2299044 Positive_regulation EPHB2 SPRY2 24744103 494840 Positive_regulation EPHB2 SPRY3 23199150 804637 Positive_regulation EPHB2 SPRY3 24250280 2299045 Positive_regulation EPHB2 SPRY4 23199150 804638 Positive_regulation EPHB2 SPRY4 23554919 2773875 Positive_regulation EPHB2 SPRY4 24250280 2299046 Positive_regulation EPHB2 SRC 11897012 389921 Positive_regulation EPHB2 SRC 12925710 1296084 Positive_regulation EPHB2 SRC 16606672 1540051 Positive_regulation EPHB2 SRC 17158954 1335293 Positive_regulation EPHB2 SRC 17319972 1645306 Positive_regulation EPHB2 SRC 17897439 461268 Positive_regulation EPHB2 SRC 18404483 3088148 Positive_regulation EPHB2 SRC 18460189 2232690 Positive_regulation EPHB2 SRC 18494562 2264552 Positive_regulation EPHB2 SRC 18494562 2264554 Positive_regulation EPHB2 SRC 19254952 1165630 Positive_regulation EPHB2 SRC 19305428 2124971 Positive_regulation EPHB2 SRC 19357636 1902993 Positive_regulation EPHB2 SRC 19602257 385588 Positive_regulation EPHB2 SRC 19602257 385593 Positive_regulation EPHB2 SRC 19602257 385601 Positive_regulation EPHB2 SRC 19602257 385665 Positive_regulation EPHB2 SRC 19943942 385869 Positive_regulation EPHB2 SRC 20038977 1910314 Positive_regulation EPHB2 SRC 20644732 2456160 Positive_regulation EPHB2 SRC 20863376 1859277 Positive_regulation EPHB2 SRC 21401944 304786 Positive_regulation EPHB2 SRC 21429240 1030058 Positive_regulation EPHB2 SRC 21505453 436761 Positive_regulation EPHB2 SRC 21599982 527409 Positive_regulation EPHB2 SRC 21599982 527410 Positive_regulation EPHB2 SRC 21765460 2140997 Positive_regulation EPHB2 SRC 21776388 1686280 Positive_regulation EPHB2 SRC 22238675 2587016 Positive_regulation EPHB2 SRC 23009336 1866982 Positive_regulation EPHB2 SRC 23942551 728410 Positive_regulation EPHB2 SRC 24751948 2956195 Positive_regulation EPHB2 SRC 25396727 3026969 Positive_regulation EPHB2 SRC 25541943 3035859 Positive_regulation EPHB2 SRC 25566074 955116 Positive_regulation EPHB2 SRC 9864370 1473411 Positive_regulation EPHB2 SRF 25354194 3020448 Positive_regulation EPHB2 SST 21589940 2523403 Positive_regulation EPHB2 SST 24416361 2907961 Positive_regulation EPHB2 SSTR1 22651821 1648792 Positive_regulation EPHB2 SSTR4 22651821 1648793 Positive_regulation EPHB2 SSX2 24787708 2958692 Positive_regulation EPHB2 ST5 23935508 2347824 Positive_regulation EPHB2 STAB2 24586357 2924393 Positive_regulation EPHB2 STAB2 24586357 2924402 Positive_regulation EPHB2 STAR 24945345 2981106 Positive_regulation EPHB2 STAT1 21526200 2514084 Positive_regulation EPHB2 STAT1 22110388 1058558 Positive_regulation EPHB2 STAT1 24821075 1087357 Positive_regulation EPHB2 STAT2 24821075 1087358 Positive_regulation EPHB2 STAT3 21103345 2483803 Positive_regulation EPHB2 STAT3 21909139 2142520 Positive_regulation EPHB2 STAT3 22937006 2682709 Positive_regulation EPHB2 STAT3 24058789 1705646 Positive_regulation EPHB2 STAT3 24058789 1705739 Positive_regulation EPHB2 STAT3 24201804 568916 Positive_regulation EPHB2 STAT3 24260222 2882868 Positive_regulation EPHB2 STAT3 24745366 132281 Positive_regulation EPHB2 STAT3 24959088 2123133 Positive_regulation EPHB2 STAT5A 23369183 472832 Positive_regulation EPHB2 STIM1 21441934 1955180 Positive_regulation EPHB2 STIM1 22298426 1800003 Positive_regulation EPHB2 STIP1 25010044 2987693 Positive_regulation EPHB2 STS 24096434 93494 Positive_regulation EPHB2 SUB1 14735164 424151 Positive_regulation EPHB2 SUB1 19930650 526191 Positive_regulation EPHB2 SUB1 19930650 526215 Positive_regulation EPHB2 SUB1 19930650 526295 Positive_regulation EPHB2 SUMF1 20643830 1559494 Positive_regulation EPHB2 SYK 11250739 457025 Positive_regulation EPHB2 SYK 21687747 922415 Positive_regulation EPHB2 SYK 21687806 922512 Positive_regulation EPHB2 SYK 22719740 901956 Positive_regulation EPHB2 SYK 22880054 2673952 Positive_regulation EPHB2 SYK 22883599 292380 Positive_regulation EPHB2 SYK 23170196 1764598 Positive_regulation EPHB2 SYK 23424645 2755069 Positive_regulation EPHB2 SYN1 17105652 106834 Positive_regulation EPHB2 SYN2 17105652 106835 Positive_regulation EPHB2 SYN3 17105652 106836 Positive_regulation EPHB2 SYNGAP1 22558107 2624478 Positive_regulation EPHB2 SYNM 23243430 816465 Positive_regulation EPHB2 TAB1 17205106 1054712 Positive_regulation EPHB2 TAB1 24550720 2300535 Positive_regulation EPHB2 TAB1 24801688 2961669 Positive_regulation EPHB2 TAB2 23586039 180945 Positive_regulation EPHB2 TAB2 23586039 181089 Positive_regulation EPHB2 TAC1 20544512 2106936 Positive_regulation EPHB2 TAC3 20544512 2106937 Positive_regulation EPHB2 TAC4 20544512 2106938 Positive_regulation EPHB2 TANK 24217713 2157715 Positive_regulation EPHB2 TANK 9432981 1602448 Positive_regulation EPHB2 TAT 22039370 1038347 Positive_regulation EPHB2 TAT 23555914 2775924 Positive_regulation EPHB2 TAT 24409324 2906892 Positive_regulation EPHB2 TBCA 18445299 1897041 Positive_regulation EPHB2 TBCA 23181395 1665155 Positive_regulation EPHB2 TBCA 23181395 1665156 Positive_regulation EPHB2 TBCA 23181395 1665157 Positive_regulation EPHB2 TBCA 24498195 2918897 Positive_regulation EPHB2 TBCA 24498195 2918920 Positive_regulation EPHB2 TBK1 24217713 2157716 Positive_regulation EPHB2 TBX5 12177047 1286326 Positive_regulation EPHB2 TBX5 12177047 1286327 Positive_regulation EPHB2 TBX5 12177047 1286337 Positive_regulation EPHB2 TBX5 12177047 1286350 Positive_regulation EPHB2 TBX5 12177047 1286354 Positive_regulation EPHB2 TCF12 20809979 386523 Positive_regulation EPHB2 TCF12 21264226 2494830 Positive_regulation EPHB2 TCF12 24852887 3157610 Positive_regulation EPHB2 TCF12 24945726 2981547 Positive_regulation EPHB2 TCF15 20809979 386524 Positive_regulation EPHB2 TCF15 21264226 2494831 Positive_regulation EPHB2 TCF15 24852887 3157611 Positive_regulation EPHB2 TCF15 24945726 2981548 Positive_regulation EPHB2 TCF19 20809979 386525 Positive_regulation EPHB2 TCF19 21264226 2494832 Positive_regulation EPHB2 TCF19 24852887 3157612 Positive_regulation EPHB2 TCF19 24945726 2981549 Positive_regulation EPHB2 TCF20 20809979 386526 Positive_regulation EPHB2 TCF20 21264226 2494833 Positive_regulation EPHB2 TCF20 24852887 3157613 Positive_regulation EPHB2 TCF20 24945726 2981550 Positive_regulation EPHB2 TCF21 20809979 386527 Positive_regulation EPHB2 TCF21 21264226 2494834 Positive_regulation EPHB2 TCF21 24852887 3157614 Positive_regulation EPHB2 TCF21 24945726 2981551 Positive_regulation EPHB2 TCF23 20809979 386531 Positive_regulation EPHB2 TCF23 21264226 2494838 Positive_regulation EPHB2 TCF23 24852887 3157618 Positive_regulation EPHB2 TCF23 24945726 2981555 Positive_regulation EPHB2 TCF24 20809979 386533 Positive_regulation EPHB2 TCF24 21264226 2494840 Positive_regulation EPHB2 TCF24 24852887 3157620 Positive_regulation EPHB2 TCF24 24945726 2981557 Positive_regulation EPHB2 TCF25 20809979 386532 Positive_regulation EPHB2 TCF25 21264226 2494839 Positive_regulation EPHB2 TCF25 24852887 3157619 Positive_regulation EPHB2 TCF25 24945726 2981556 Positive_regulation EPHB2 TCF3 20809979 386528 Positive_regulation EPHB2 TCF3 21264226 2494835 Positive_regulation EPHB2 TCF3 24852887 3157615 Positive_regulation EPHB2 TCF3 24945726 2981552 Positive_regulation EPHB2 TCF4 20809979 386529 Positive_regulation EPHB2 TCF4 21264226 2494836 Positive_regulation EPHB2 TCF4 24852887 3157616 Positive_regulation EPHB2 TCF4 24945726 2981553 Positive_regulation EPHB2 TCF7 20809979 386530 Positive_regulation EPHB2 TCF7 21264226 2494837 Positive_regulation EPHB2 TCF7 24852887 3157617 Positive_regulation EPHB2 TCF7 24945726 2981554 Positive_regulation EPHB2 TDGF1 18197245 2382448 Positive_regulation EPHB2 TERF1 15026815 424432 Positive_regulation EPHB2 TERF1 19137382 621162 Positive_regulation EPHB2 TERF1 19804630 401970 Positive_regulation EPHB2 TERF1 25118589 1944693 Positive_regulation EPHB2 TERF1 25629002 949878 Positive_regulation EPHB2 TERF2 15026815 424433 Positive_regulation EPHB2 TERF2 16787538 3096287 Positive_regulation EPHB2 TERF2 19137382 621163 Positive_regulation EPHB2 TERF2 19804630 401931 Positive_regulation EPHB2 TERF2 19804630 401971 Positive_regulation EPHB2 TERF2 23758320 151617 Positive_regulation EPHB2 TERF2 23758320 151635 Positive_regulation EPHB2 TERF2 25118589 1944694 Positive_regulation EPHB2 TERF2 25629002 949879 Positive_regulation EPHB2 TERF2IP 15026815 424436 Positive_regulation EPHB2 TERF2IP 16787538 3096289 Positive_regulation EPHB2 TERF2IP 19137382 621166 Positive_regulation EPHB2 TERF2IP 19804630 401933 Positive_regulation EPHB2 TERF2IP 19804630 401974 Positive_regulation EPHB2 TERF2IP 23758320 151619 Positive_regulation EPHB2 TERF2IP 23758320 151637 Positive_regulation EPHB2 TERF2IP 25118589 1944697 Positive_regulation EPHB2 TERF2IP 25629002 949882 Positive_regulation EPHB2 TFAP2A 19701232 8038 Positive_regulation EPHB2 TFF3 24978043 2985479 Positive_regulation EPHB2 TGFB1 22111877 334583 Positive_regulation EPHB2 TGFB1 22111877 334584 Positive_regulation EPHB2 TGFB1 22111877 334616 Positive_regulation EPHB2 TGFB1 22111877 334617 Positive_regulation EPHB2 TGFB1 24957684 2232002 Positive_regulation EPHB2 THBS1 21453480 855655 Positive_regulation EPHB2 THEMIS 21189249 1190228 Positive_regulation EPHB2 THEMIS 21189249 1190236 Positive_regulation EPHB2 THPO 19619605 833443 Positive_regulation EPHB2 TIAM1 20824214 2474003 Positive_regulation EPHB2 TIAM2 20824214 2474004 Positive_regulation EPHB2 TIE1 19435476 659224 Positive_regulation EPHB2 TIE1 25072663 1943764 Positive_regulation EPHB2 TIMP1 22327365 1928207 Positive_regulation EPHB2 TIMP1 22327365 1928208 Positive_regulation EPHB2 TIMP1 22327365 1928210 Positive_regulation EPHB2 TIMP2 24970341 1668281 Positive_regulation EPHB2 TINF2 15026815 424434 Positive_regulation EPHB2 TINF2 19137382 621164 Positive_regulation EPHB2 TINF2 19804630 401972 Positive_regulation EPHB2 TINF2 25118589 1944695 Positive_regulation EPHB2 TINF2 25629002 949880 Positive_regulation EPHB2 TLR1 17935622 352057 Positive_regulation EPHB2 TLR1 19667062 1555549 Positive_regulation EPHB2 TLR1 22253793 2587938 Positive_regulation EPHB2 TLR1 22253793 2587979 Positive_regulation EPHB2 TLR1 22253793 2587999 Positive_regulation EPHB2 TLR1 22763455 1988842 Positive_regulation EPHB2 TLR1 22927911 2681044 Positive_regulation EPHB2 TLR1 24980047 1576824 Positive_regulation EPHB2 TLR10 17935622 352065 Positive_regulation EPHB2 TLR10 19667062 1555558 Positive_regulation EPHB2 TLR10 22253793 2587946 Positive_regulation EPHB2 TLR10 22253793 2587987 Positive_regulation EPHB2 TLR10 22253793 2588007 Positive_regulation EPHB2 TLR10 22763455 1988850 Positive_regulation EPHB2 TLR10 22927911 2681052 Positive_regulation EPHB2 TLR10 24980047 1576832 Positive_regulation EPHB2 TLR2 17935622 352058 Positive_regulation EPHB2 TLR2 19252500 1960615 Positive_regulation EPHB2 TLR2 19252500 1960632 Positive_regulation EPHB2 TLR2 19252500 1960638 Positive_regulation EPHB2 TLR2 19252500 1960640 Positive_regulation EPHB2 TLR2 19667062 1555550 Positive_regulation EPHB2 TLR2 21321383 2175420 Positive_regulation EPHB2 TLR2 21674065 2528585 Positive_regulation EPHB2 TLR2 21998707 2562076 Positive_regulation EPHB2 TLR2 22253793 2587939 Positive_regulation EPHB2 TLR2 22253793 2587980 Positive_regulation EPHB2 TLR2 22253793 2588000 Positive_regulation EPHB2 TLR2 22763455 1988843 Positive_regulation EPHB2 TLR2 22927911 2681045 Positive_regulation EPHB2 TLR2 23133361 2297579 Positive_regulation EPHB2 TLR2 24980047 1576825 Positive_regulation EPHB2 TLR2 25525300 1763264 Positive_regulation EPHB2 TLR3 17935622 352059 Positive_regulation EPHB2 TLR3 19667062 1555551 Positive_regulation EPHB2 TLR3 21860608 1038247 Positive_regulation EPHB2 TLR3 22253793 2587940 Positive_regulation EPHB2 TLR3 22253793 2587981 Positive_regulation EPHB2 TLR3 22253793 2588001 Positive_regulation EPHB2 TLR3 22763455 1988844 Positive_regulation EPHB2 TLR3 22927911 2681046 Positive_regulation EPHB2 TLR3 24980047 1576826 Positive_regulation EPHB2 TLR4 12117640 791164 Positive_regulation EPHB2 TLR4 15575964 1844356 Positive_regulation EPHB2 TLR4 15767367 1534847 Positive_regulation EPHB2 TLR4 17935622 352060 Positive_regulation EPHB2 TLR4 19169268 6913 Positive_regulation EPHB2 TLR4 19399172 2415460 Positive_regulation EPHB2 TLR4 19667062 1555552 Positive_regulation EPHB2 TLR4 19667062 1555553 Positive_regulation EPHB2 TLR4 20827308 979273 Positive_regulation EPHB2 TLR4 21321383 2175415 Positive_regulation EPHB2 TLR4 21321383 2175419 Positive_regulation EPHB2 TLR4 22253793 2587941 Positive_regulation EPHB2 TLR4 22253793 2587982 Positive_regulation EPHB2 TLR4 22253793 2588002 Positive_regulation EPHB2 TLR4 22610140 1957421 Positive_regulation EPHB2 TLR4 22763455 1988845 Positive_regulation EPHB2 TLR4 22883599 292381 Positive_regulation EPHB2 TLR4 22927911 2681047 Positive_regulation EPHB2 TLR4 24980047 1576827 Positive_regulation EPHB2 TLR4 25101851 2995834 Positive_regulation EPHB2 TLR5 17935622 352061 Positive_regulation EPHB2 TLR5 19667062 1555554 Positive_regulation EPHB2 TLR5 22253793 2587942 Positive_regulation EPHB2 TLR5 22253793 2587983 Positive_regulation EPHB2 TLR5 22253793 2588003 Positive_regulation EPHB2 TLR5 22763455 1988846 Positive_regulation EPHB2 TLR5 22927911 2681048 Positive_regulation EPHB2 TLR5 24980047 1576828 Positive_regulation EPHB2 TLR6 17935622 352066 Positive_regulation EPHB2 TLR6 19667062 1555559 Positive_regulation EPHB2 TLR6 22253793 2587947 Positive_regulation EPHB2 TLR6 22253793 2587988 Positive_regulation EPHB2 TLR6 22253793 2588008 Positive_regulation EPHB2 TLR6 22763455 1988851 Positive_regulation EPHB2 TLR6 22927911 2681053 Positive_regulation EPHB2 TLR6 24980047 1576833 Positive_regulation EPHB2 TLR7 17935622 352062 Positive_regulation EPHB2 TLR7 19667062 1555555 Positive_regulation EPHB2 TLR7 22253793 2587943 Positive_regulation EPHB2 TLR7 22253793 2587984 Positive_regulation EPHB2 TLR7 22253793 2588004 Positive_regulation EPHB2 TLR7 22763455 1988847 Positive_regulation EPHB2 TLR7 22927911 2681049 Positive_regulation EPHB2 TLR7 24980047 1576829 Positive_regulation EPHB2 TLR8 17935622 352063 Positive_regulation EPHB2 TLR8 19667062 1555556 Positive_regulation EPHB2 TLR8 22253793 2587944 Positive_regulation EPHB2 TLR8 22253793 2587985 Positive_regulation EPHB2 TLR8 22253793 2588005 Positive_regulation EPHB2 TLR8 22763455 1988848 Positive_regulation EPHB2 TLR8 22927911 2681050 Positive_regulation EPHB2 TLR8 24980047 1576830 Positive_regulation EPHB2 TLR9 17935622 352064 Positive_regulation EPHB2 TLR9 19667062 1555557 Positive_regulation EPHB2 TLR9 22253793 2587945 Positive_regulation EPHB2 TLR9 22253793 2587986 Positive_regulation EPHB2 TLR9 22253793 2588006 Positive_regulation EPHB2 TLR9 22763455 1988849 Positive_regulation EPHB2 TLR9 22927911 2681051 Positive_regulation EPHB2 TLR9 23109291 779259 Positive_regulation EPHB2 TLR9 23109291 779260 Positive_regulation EPHB2 TLR9 24980047 1576831 Positive_regulation EPHB2 TMBIM6 24894176 682712 Positive_regulation EPHB2 TMBIM6 24894176 682715 Positive_regulation EPHB2 TNF 11136824 1518276 Positive_regulation EPHB2 TNF 16207331 104237 Positive_regulation EPHB2 TNF 16207331 104268 Positive_regulation EPHB2 TNF 17105652 106837 Positive_regulation EPHB2 TNF 17567906 370619 Positive_regulation EPHB2 TNF 19594939 313132 Positive_regulation EPHB2 TNF 19808894 711200 Positive_regulation EPHB2 TNF 19955213 1771476 Positive_regulation EPHB2 TNF 20624904 1377599 Positive_regulation EPHB2 TNF 20830230 1711854 Positive_regulation EPHB2 TNF 21345249 121578 Positive_regulation EPHB2 TNF 21853090 2543196 Positive_regulation EPHB2 TNF 22046506 1686737 Positive_regulation EPHB2 TNF 22140576 2576894 Positive_regulation EPHB2 TNF 22396737 2608328 Positive_regulation EPHB2 TNF 22396737 2608329 Positive_regulation EPHB2 TNF 22396737 2608330 Positive_regulation EPHB2 TNF 22396737 2608353 Positive_regulation EPHB2 TNF 22396737 2608455 Positive_regulation EPHB2 TNF 22396737 2608460 Positive_regulation EPHB2 TNF 22408456 1095214 Positive_regulation EPHB2 TNF 22482044 661511 Positive_regulation EPHB2 TNF 22837815 3131083 Positive_regulation EPHB2 TNF 22988345 1750573 Positive_regulation EPHB2 TNF 23071583 2703143 Positive_regulation EPHB2 TNF 23150750 2225204 Positive_regulation EPHB2 TNF 23152905 2716800 Positive_regulation EPHB2 TNF 23213344 1156367 Positive_regulation EPHB2 TNF 23389627 1811782 Positive_regulation EPHB2 TNF 23389627 1811783 Positive_regulation EPHB2 TNF 23389627 1811849 Positive_regulation EPHB2 TNF 23389627 1811953 Positive_regulation EPHB2 TNF 23651618 3085075 Positive_regulation EPHB2 TNF 23691498 181464 Positive_regulation EPHB2 TNF 23784308 606109 Positive_regulation EPHB2 TNF 23844119 2819476 Positive_regulation EPHB2 TNF 23861891 2820569 Positive_regulation EPHB2 TNF 24086560 2854635 Positive_regulation EPHB2 TNF 24086560 2854644 Positive_regulation EPHB2 TNF 24086560 2854645 Positive_regulation EPHB2 TNF 24352036 1632442 Positive_regulation EPHB2 TNF 24386331 2903613 Positive_regulation EPHB2 TNF 24495480 131697 Positive_regulation EPHB2 TNF 24586980 2928513 Positive_regulation EPHB2 TNF 24586980 2928614 Positive_regulation EPHB2 TNF 24586980 2928631 Positive_regulation EPHB2 TNF 24586980 2928632 Positive_regulation EPHB2 TNF 24603712 2931983 Positive_regulation EPHB2 TNF 24826069 1917011 Positive_regulation EPHB2 TNF 9400710 797302 Positive_regulation EPHB2 TNFRSF11B 24267510 1678915 Positive_regulation EPHB2 TNFRSF13C 23453634 1040934 Positive_regulation EPHB2 TNFRSF25 24453414 1756720 Positive_regulation EPHB2 TNFRSF6B 22672288 355951 Positive_regulation EPHB2 TNFRSF8 22852078 1689347 Positive_regulation EPHB2 TNFRSF9 22039370 1038348 Positive_regulation EPHB2 TNFRSF9 23874982 2823955 Positive_regulation EPHB2 TNFRSF9 23874982 2823967 Positive_regulation EPHB2 TNFRSF9 23874982 2824003 Positive_regulation EPHB2 TNFSF10 20839416 806597 Positive_regulation EPHB2 TNFSF10 21463519 1861160 Positive_regulation EPHB2 TNFSF10 22719861 2653311 Positive_regulation EPHB2 TNFSF10 25013758 194482 Positive_regulation EPHB2 TNFSF11 16606672 1540042 Positive_regulation EPHB2 TNFSF11 16987426 106647 Positive_regulation EPHB2 TNFSF11 16987426 106666 Positive_regulation EPHB2 TNFSF11 16987426 106667 Positive_regulation EPHB2 TNFSF11 21861861 123792 Positive_regulation EPHB2 TNFSF11 22416217 1714089 Positive_regulation EPHB2 TNFSF11 22558291 2625013 Positive_regulation EPHB2 TNFSF11 22558291 2625021 Positive_regulation EPHB2 TNFSF11 23243450 816599 Positive_regulation EPHB2 TNFSF11 23509596 817529 Positive_regulation EPHB2 TNFSF11 23509596 817537 Positive_regulation EPHB2 TNFSF11 23680047 294369 Positive_regulation EPHB2 TNFSF11 23692684 294395 Positive_regulation EPHB2 TNFSF11 23762163 820148 Positive_regulation EPHB2 TNFSF11 23762163 820191 Positive_regulation EPHB2 TNFSF11 23762163 820192 Positive_regulation EPHB2 TNFSF11 23762163 820198 Positive_regulation EPHB2 TNFSF11 23762163 820199 Positive_regulation EPHB2 TNFSF11 23762163 820203 Positive_regulation EPHB2 TNFSF11 24119769 1700738 Positive_regulation EPHB2 TNFSF11 24174976 823613 Positive_regulation EPHB2 TNFSF11 24314143 222331 Positive_regulation EPHB2 TNFSF11 24314143 222346 Positive_regulation EPHB2 TNFSF11 24324641 2890913 Positive_regulation EPHB2 TNFSF11 24324641 2890917 Positive_regulation EPHB2 TNFSF11 24324641 2890918 Positive_regulation EPHB2 TNFSF11 24340030 2894729 Positive_regulation EPHB2 TNFSF11 24370273 271015 Positive_regulation EPHB2 TNFSF11 24444335 295667 Positive_regulation EPHB2 TNFSF11 24444335 295668 Positive_regulation EPHB2 TNFSF11 24444335 295683 Positive_regulation EPHB2 TNFSF11 24444335 295687 Positive_regulation EPHB2 TNFSF11 24558484 2923891 Positive_regulation EPHB2 TNFSF11 24586466 2925020 Positive_regulation EPHB2 TNFSF11 24781012 1941802 Positive_regulation EPHB2 TNFSF11 24886323 411125 Positive_regulation EPHB2 TNFSF11 25134536 1883918 Positive_regulation EPHB2 TNFSF11 25134536 1883919 Positive_regulation EPHB2 TNFSF11 25134536 1883921 Positive_regulation EPHB2 TNFSF11 25221602 1071121 Positive_regulation EPHB2 TNFSF11 25421321 1731528 Positive_regulation EPHB2 TNFSF13B 16301744 1538423 Positive_regulation EPHB2 TNFSF13B 16301744 1538462 Positive_regulation EPHB2 TNFSF13B 16301744 1538466 Positive_regulation EPHB2 TNFSF13B 16301744 1538468 Positive_regulation EPHB2 TNFSF13B 16301744 1538470 Positive_regulation EPHB2 TNFSF13B 23453634 1040899 Positive_regulation EPHB2 TNFSF13B 23453634 1040910 Positive_regulation EPHB2 TNFSF13B 23620746 2783273 Positive_regulation EPHB2 TNFSF15 24453414 1756721 Positive_regulation EPHB2 TNMD 18931684 1960474 Positive_regulation EPHB2 TNNI3K 23472207 2764557 Positive_regulation EPHB2 TNNI3K 23472207 2764567 Positive_regulation EPHB2 TNPO1 22211090 1084200 Positive_regulation EPHB2 TNPO1 22211090 1084202 Positive_regulation EPHB2 TP53 18847491 251679 Positive_regulation EPHB2 TP53 20190820 2129187 Positive_regulation EPHB2 TP53 20190820 2129188 Positive_regulation EPHB2 TP53 20727231 466212 Positive_regulation EPHB2 TP53 21422497 29150 Positive_regulation EPHB2 TP53 22842735 15813 Positive_regulation EPHB2 TP53 23342042 2741758 Positive_regulation EPHB2 TP53 23559009 561045 Positive_regulation EPHB2 TP53 23844043 2819132 Positive_regulation EPHB2 TP53 24250280 2299030 Positive_regulation EPHB2 TP53 25028057 174393 Positive_regulation EPHB2 TP53 25068118 3167128 Positive_regulation EPHB2 TPO 16834459 2368833 Positive_regulation EPHB2 TPO 20838657 2272426 Positive_regulation EPHB2 TPO 23060884 904635 Positive_regulation EPHB2 TPO 24086539 2854582 Positive_regulation EPHB2 TPO 24407241 570855 Positive_regulation EPHB2 TRAF2 9432981 1602481 Positive_regulation EPHB2 TRAF3 21078888 1561518 Positive_regulation EPHB2 TRAF3 24378539 1574370 Positive_regulation EPHB2 TRAF3 25010048 2987744 Positive_regulation EPHB2 TRAF3 9432981 1602450 Positive_regulation EPHB2 TRAF3 9432981 1602483 Positive_regulation EPHB2 TRAF3IP2 23042150 1957923 Positive_regulation EPHB2 TRAF3IP2 24586980 2928514 Positive_regulation EPHB2 TRAF3IP2 24586980 2928633 Positive_regulation EPHB2 TRAF3IP2 24892823 2976009 Positive_regulation EPHB2 TRAF5 9432981 1602451 Positive_regulation EPHB2 TRAF6 20100871 1557341 Positive_regulation EPHB2 TRAF6 23586039 180943 Positive_regulation EPHB2 TRAF6 23586039 181087 Positive_regulation EPHB2 TRAF6 9432981 1602410 Positive_regulation EPHB2 TRAF6 9432981 1602423 Positive_regulation EPHB2 TRAF6 9432981 1602424 Positive_regulation EPHB2 TRAF6 9432981 1602452 Positive_regulation EPHB2 TRAF6 9432981 1602469 Positive_regulation EPHB2 TRAF6 9432981 1602476 Positive_regulation EPHB2 TRAPPC4 24717932 1023907 Positive_regulation EPHB2 TRAPPC4 24717932 1023934 Positive_regulation EPHB2 TRAPPC4 24717932 1023935 Positive_regulation EPHB2 TRAPPC4 24717932 1023942 Positive_regulation EPHB2 TREM2 15728241 1534816 Positive_regulation EPHB2 TREM2 24395130 1890465 Positive_regulation EPHB2 TRH 21464994 2510796 Positive_regulation EPHB2 TRIP4 16908670 1331931 Positive_regulation EPHB2 TRNAI1 21042538 2479713 Positive_regulation EPHB2 TRPC1 19680266 546194 Positive_regulation EPHB2 TRPC2 19680266 546195 Positive_regulation EPHB2 TRPC3 19680266 546196 Positive_regulation EPHB2 TRPC4 19680266 546197 Positive_regulation EPHB2 TRPC5 19680266 546160 Positive_regulation EPHB2 TRPC5 19680266 546198 Positive_regulation EPHB2 TRPC6 19680266 546199 Positive_regulation EPHB2 TRPC7 19680266 546200 Positive_regulation EPHB2 TRPM7 24223965 2877502 Positive_regulation EPHB2 TRPM7 24223965 2877508 Positive_regulation EPHB2 TRPV1 16412244 1896765 Positive_regulation EPHB2 TRPV1 17603899 1896884 Positive_regulation EPHB2 TRPV1 22216270 2585202 Positive_regulation EPHB2 TRPV1 23097675 816053 Positive_regulation EPHB2 TRPV1 24381558 963168 Positive_regulation EPHB2 TSC22D3 22396737 2608456 Positive_regulation EPHB2 TTC1 22069568 3182017 Positive_regulation EPHB2 TTC12 22069568 3182026 Positive_regulation EPHB2 TTC13 22069568 3182037 Positive_regulation EPHB2 TTC14 22069568 3182027 Positive_regulation EPHB2 TTC16 22069568 3182038 Positive_regulation EPHB2 TTC17 22069568 3182030 Positive_regulation EPHB2 TTC18 22069568 3182042 Positive_regulation EPHB2 TTC19 22069568 3182034 Positive_regulation EPHB2 TTC22 22069568 3182035 Positive_regulation EPHB2 TTC23 22069568 3182031 Positive_regulation EPHB2 TTC24 22069568 3182043 Positive_regulation EPHB2 TTC25 22069568 3182029 Positive_regulation EPHB2 TTC26 22069568 3182024 Positive_regulation EPHB2 TTC27 22069568 3182033 Positive_regulation EPHB2 TTC28 22069568 3182039 Positive_regulation EPHB2 TTC29 22069568 3182040 Positive_regulation EPHB2 TTC3 22069568 3182018 Positive_regulation EPHB2 TTC31 22069568 3182032 Positive_regulation EPHB2 TTC32 22069568 3182044 Positive_regulation EPHB2 TTC33 22069568 3182041 Positive_regulation EPHB2 TTC34 22069568 3182046 Positive_regulation EPHB2 TTC36 22069568 3182045 Positive_regulation EPHB2 TTC37 22069568 3182025 Positive_regulation EPHB2 TTC38 22069568 3182036 Positive_regulation EPHB2 TTC4 22069568 3182019 Positive_regulation EPHB2 TTC40 22069568 3182028 Positive_regulation EPHB2 TTC5 22069568 3182020 Positive_regulation EPHB2 TTC6 22069568 3182021 Positive_regulation EPHB2 TTC8 22069568 3182022 Positive_regulation EPHB2 TTC9 22069568 3182023 Positive_regulation EPHB2 TYR 18460189 2232691 Positive_regulation EPHB2 TYR 21124310 1918114 Positive_regulation EPHB2 TYR 22013440 680192 Positive_regulation EPHB2 TYR 24201804 568917 Positive_regulation EPHB2 TYR 24503862 2920011 Positive_regulation EPHB2 TYR 24763051 574234 Positive_regulation EPHB2 UBE2V1 23586039 180944 Positive_regulation EPHB2 UBE2V1 23586039 181088 Positive_regulation EPHB2 UNC119 23535298 543123 Positive_regulation EPHB2 UNC119 23535298 543141 Positive_regulation EPHB2 UTP15 18404483 3088102 Positive_regulation EPHB2 UTP18 18404483 3088100 Positive_regulation EPHB2 UTP20 18404483 3088098 Positive_regulation EPHB2 UTP23 18404483 3088103 Positive_regulation EPHB2 UTP3 18404483 3088101 Positive_regulation EPHB2 UTP6 18404483 3088099 Positive_regulation EPHB2 UTS2 20859543 3208916 Positive_regulation EPHB2 UTS2 20859543 3208917 Positive_regulation EPHB2 UTS2 20859543 3208955 Positive_regulation EPHB2 UTS2 20859543 3208987 Positive_regulation EPHB2 UTS2 20859543 3208992 Positive_regulation EPHB2 UTS2 20859543 3209011 Positive_regulation EPHB2 UTS2R 20859543 3208920 Positive_regulation EPHB2 UTS2R 20859543 3208921 Positive_regulation EPHB2 UTS2R 20859543 3208922 Positive_regulation EPHB2 UTS2R 20859543 3208923 Positive_regulation EPHB2 UTS2R 20859543 3208937 Positive_regulation EPHB2 UTS2R 20859543 3208960 Positive_regulation EPHB2 UTS2R 20859543 3208961 Positive_regulation EPHB2 UTS2R 20859543 3209002 Positive_regulation EPHB2 UTS2R 20859543 3209004 Positive_regulation EPHB2 VAV1 11413196 1519513 Positive_regulation EPHB2 VAV1 11413196 1519517 Positive_regulation EPHB2 VAV1 16709244 524758 Positive_regulation EPHB2 VAV1 16709244 524763 Positive_regulation EPHB2 VAV1 16709244 524764 Positive_regulation EPHB2 VAV1 23342133 2742528 Positive_regulation EPHB2 VAV1 23758320 151507 Positive_regulation EPHB2 VAV2 21625594 2524974 Positive_regulation EPHB2 VAV3 23566222 1867797 Positive_regulation EPHB2 VAV3 23566222 1867815 Positive_regulation EPHB2 VCAM1 24253666 3138730 Positive_regulation EPHB2 VCP 24667437 2938736 Positive_regulation EPHB2 VEGFA 10646893 416022 Positive_regulation EPHB2 VEGFA 11927607 1280792 Positive_regulation EPHB2 VEGFA 11961297 1632909 Positive_regulation EPHB2 VEGFA 11961297 1632910 Positive_regulation EPHB2 VEGFA 12069692 225061 Positive_regulation EPHB2 VEGFA 12177047 1286351 Positive_regulation EPHB2 VEGFA 12925710 1296028 Positive_regulation EPHB2 VEGFA 12925710 1296091 Positive_regulation EPHB2 VEGFA 12925710 1296099 Positive_regulation EPHB2 VEGFA 12952943 1296729 Positive_regulation EPHB2 VEGFA 12952943 1296730 Positive_regulation EPHB2 VEGFA 12952943 1296781 Positive_regulation EPHB2 VEGFA 12952943 1296804 Positive_regulation EPHB2 VEGFA 16982804 1334076 Positive_regulation EPHB2 VEGFA 16982804 1334105 Positive_regulation EPHB2 VEGFA 17459161 3108297 Positive_regulation EPHB2 VEGFA 18334941 1907955 Positive_regulation EPHB2 VEGFA 18391074 1351081 Positive_regulation EPHB2 VEGFA 18391074 1351115 Positive_regulation EPHB2 VEGFA 18391074 1351123 Positive_regulation EPHB2 VEGFA 18852899 2397581 Positive_regulation EPHB2 VEGFA 19325845 1087964 Positive_regulation EPHB2 VEGFA 19424491 2415992 Positive_regulation EPHB2 VEGFA 19424491 2415996 Positive_regulation EPHB2 VEGFA 19424491 2415997 Positive_regulation EPHB2 VEGFA 19834490 546403 Positive_regulation EPHB2 VEGFA 20222950 255570 Positive_regulation EPHB2 VEGFA 20657775 2456439 Positive_regulation EPHB2 VEGFA 20700512 2458133 Positive_regulation EPHB2 VEGFA 20813052 1858493 Positive_regulation EPHB2 VEGFA 21507243 3207164 Positive_regulation EPHB2 VEGFA 21507243 3207199 Positive_regulation EPHB2 VEGFA 21507243 3207255 Positive_regulation EPHB2 VEGFA 21625731 1161941 Positive_regulation EPHB2 VEGFA 21756365 405112 Positive_regulation EPHB2 VEGFA 21756365 405113 Positive_regulation EPHB2 VEGFA 21756365 405114 Positive_regulation EPHB2 VEGFA 21756365 405115 Positive_regulation EPHB2 VEGFA 21756365 405128 Positive_regulation EPHB2 VEGFA 21828096 703023 Positive_regulation EPHB2 VEGFA 21828096 703030 Positive_regulation EPHB2 VEGFA 22294553 777964 Positive_regulation EPHB2 VEGFA 22350787 477334 Positive_regulation EPHB2 VEGFA 22363548 2600000 Positive_regulation EPHB2 VEGFA 23639442 700598 Positive_regulation EPHB2 VEGFA 23639442 700599 Positive_regulation EPHB2 VEGFA 23639442 700603 Positive_regulation EPHB2 VEGFA 23639442 700604 Positive_regulation EPHB2 VEGFA 23639442 700614 Positive_regulation EPHB2 VEGFA 23639442 700615 Positive_regulation EPHB2 VEGFA 23639442 700616 Positive_regulation EPHB2 VEGFA 23639442 700624 Positive_regulation EPHB2 VEGFA 23639442 700627 Positive_regulation EPHB2 VEGFA 23803732 543633 Positive_regulation EPHB2 VEGFA 23803732 543635 Positive_regulation EPHB2 VEGFA 23803732 543637 Positive_regulation EPHB2 VEGFA 23815774 380278 Positive_regulation EPHB2 VEGFA 24018888 1112425 Positive_regulation EPHB2 VEGFA 24312323 2888507 Positive_regulation EPHB2 VEGFA 24312323 2888522 Positive_regulation EPHB2 VEGFA 24419232 506348 Positive_regulation EPHB2 VEGFA 24489709 2916085 Positive_regulation EPHB2 VEGFA 24586357 2924392 Positive_regulation EPHB2 VEGFA 24647208 2936058 Positive_regulation EPHB2 VEGFA 24647208 2936067 Positive_regulation EPHB2 VEGFA 24647208 2936080 Positive_regulation EPHB2 VEGFA 24647208 2936088 Positive_regulation EPHB2 VEGFA 24672735 3151535 Positive_regulation EPHB2 VEGFA 24696529 738377 Positive_regulation EPHB2 VEGFA 24744103 494599 Positive_regulation EPHB2 VEGFA 24744103 494820 Positive_regulation EPHB2 VEGFA 24756564 3082111 Positive_regulation EPHB2 VEGFA 24756564 3082120 Positive_regulation EPHB2 VEGFA 24923411 132739 Positive_regulation EPHB2 VEGFA 24938229 1883865 Positive_regulation EPHB2 VEGFA 24970177 208770 Positive_regulation EPHB2 VEGFA 25145356 612791 Positive_regulation EPHB2 VEGFA 25197665 198882 Positive_regulation EPHB2 VEGFA 25369078 3022211 Positive_regulation EPHB2 VEGFA 25369078 3022212 Positive_regulation EPHB2 VEGFC 20625388 2454920 Positive_regulation EPHB2 VEGFC 20625388 2454927 Positive_regulation EPHB2 VEGFC 22745786 2656453 Positive_regulation EPHB2 VEGFC 22745786 2656471 Positive_regulation EPHB2 VEGFC 23344023 1100626 Positive_regulation EPHB2 VEGFC 24046321 703711 Positive_regulation EPHB2 VEGFC 24046321 703714 Positive_regulation EPHB2 VEGFC 24046321 703717 Positive_regulation EPHB2 VEGFC 25383712 3024286 Positive_regulation EPHB2 VIM 20515451 2112672 Positive_regulation EPHB2 VIM 23690850 819075 Positive_regulation EPHB2 VIMP 24667437 2938738 Positive_regulation EPHB2 VIP 23549262 1104646 Positive_regulation EPHB2 VIPR1 23549262 1104318 Positive_regulation EPHB2 VLDLR 11266465 1269110 Positive_regulation EPHB2 VLDLR 23318582 611030 Positive_regulation EPHB2 WAS 21441990 936224 Positive_regulation EPHB2 WASL 19419567 525432 Positive_regulation EPHB2 WDR61 21298035 2499393 Positive_regulation EPHB2 WDR61 21298035 2499394 Positive_regulation EPHB2 WDR61 23911909 1637732 Positive_regulation EPHB2 WDR61 23911909 1637733 Positive_regulation EPHB2 WDR61 23911909 1637795 Positive_regulation EPHB2 WDR61 23911909 1637808 Positive_regulation EPHB2 WDR61 23911909 1637809 Positive_regulation EPHB2 WDR61 23911909 1637839 Positive_regulation EPHB2 WDR61 23911909 1637840 Positive_regulation EPHB2 WDR61 23911909 1637841 Positive_regulation EPHB2 WDR61 24886678 1618987 Positive_regulation EPHB2 WDR61 25261977 1510730 Positive_regulation EPHB2 WNT1 17897439 461269 Positive_regulation EPHB2 WNT1 19144211 463451 Positive_regulation EPHB2 WNT1 19349579 1364804 Positive_regulation EPHB2 WNT1 19664193 464656 Positive_regulation EPHB2 WNT1 20011526 2433379 Positive_regulation EPHB2 WNT1 23613959 2782853 Positive_regulation EPHB2 WNT1 24103789 626398 Positive_regulation EPHB2 WNT1 24735639 1668063 Positive_regulation EPHB2 WNT11 19144211 463452 Positive_regulation EPHB2 WNT11 19664193 464657 Positive_regulation EPHB2 WNT11 20011526 2433380 Positive_regulation EPHB2 WNT11 23613959 2782854 Positive_regulation EPHB2 WNT11 24103789 626399 Positive_regulation EPHB2 WNT11 24735639 1668064 Positive_regulation EPHB2 WNT16 19144211 463457 Positive_regulation EPHB2 WNT16 19664193 464662 Positive_regulation EPHB2 WNT16 20011526 2433386 Positive_regulation EPHB2 WNT16 23613959 2782859 Positive_regulation EPHB2 WNT16 24103789 626404 Positive_regulation EPHB2 WNT16 24735639 1668069 Positive_regulation EPHB2 WNT2 19144211 463453 Positive_regulation EPHB2 WNT2 19664193 464658 Positive_regulation EPHB2 WNT2 20011526 2433381 Positive_regulation EPHB2 WNT2 23613959 2782855 Positive_regulation EPHB2 WNT2 24103789 626400 Positive_regulation EPHB2 WNT2 24735639 1668065 Positive_regulation EPHB2 WNT3 19144211 463454 Positive_regulation EPHB2 WNT3 19664193 464659 Positive_regulation EPHB2 WNT3 20011526 2433382 Positive_regulation EPHB2 WNT3 23613959 2782856 Positive_regulation EPHB2 WNT3 24103789 626401 Positive_regulation EPHB2 WNT3 24735639 1668066 Positive_regulation EPHB2 WNT3A 20011526 2433357 Positive_regulation EPHB2 WNT3A 20011526 2433385 Positive_regulation EPHB2 WNT3A 22966240 636915 Positive_regulation EPHB2 WNT4 19144211 463455 Positive_regulation EPHB2 WNT4 19664193 464660 Positive_regulation EPHB2 WNT4 20011526 2433383 Positive_regulation EPHB2 WNT4 23613959 2782857 Positive_regulation EPHB2 WNT4 24103789 626402 Positive_regulation EPHB2 WNT4 24735639 1668067 Positive_regulation EPHB2 WNT5A 22073312 2569894 Positive_regulation EPHB2 WNT5A 23764954 838984 Positive_regulation EPHB2 WNT5A 24524196 484243 Positive_regulation EPHB2 WNT6 19144211 463456 Positive_regulation EPHB2 WNT6 19664193 464661 Positive_regulation EPHB2 WNT6 20011526 2433384 Positive_regulation EPHB2 WNT6 23613959 2782858 Positive_regulation EPHB2 WNT6 24103789 626403 Positive_regulation EPHB2 WNT6 24735639 1668068 Positive_regulation EPHB2 XIAP 23928917 3136690 Positive_regulation EPHB2 XRCC5 16787538 3096288 Positive_regulation EPHB2 XRCC5 19804630 401932 Positive_regulation EPHB2 XRCC5 23758320 151618 Positive_regulation EPHB2 XRCC5 23758320 151636 Positive_regulation EPHB2 XRCC6 16787538 3096291 Positive_regulation EPHB2 XRCC6 19804630 401936 Positive_regulation EPHB2 XRCC6 23758320 151621 Positive_regulation EPHB2 XRCC6 23758320 151639 Positive_regulation EPHB2 YWHAB 11157988 1267374 Positive_regulation EPHB2 YWHAB 16129781 1323441 Positive_regulation EPHB2 YWHAB 18332218 1349874 Positive_regulation EPHB2 YWHAB 18335053 2386952 Positive_regulation EPHB2 YWHAB 21081934 436213 Positive_regulation EPHB2 YWHAB 21107320 1986759 Positive_regulation EPHB2 YWHAB 22529971 2620781 Positive_regulation EPHB2 YWHAB 23970928 822292 Positive_regulation EPHB2 YWHAB 24918056 853892 Positive_regulation EPHB2 ZAP70 12591907 1526034 Positive_regulation EPHB2 ZAP70 21037577 1954560 Positive_regulation EPHB2 ZAP70 24596147 753316 Positive_regulation EPHB2 ZAP70 24876949 141010 Positive_regulation EPHB2 ZC3H12A 24336080 570366 Positive_regulation EPHB2 ZGLP1 21833779 3310 Positive_regulation EPHB2 ZGLP1 22412973 2609906 Positive_regulation EPHB2 ZGLP1 22412973 2609907 Positive_regulation EPHB2 ZGLP1 22412973 2609908 Positive_regulation EPHB2 ZGLP1 22412973 2609909 Positive_regulation EPHB2 ZGLP1 22412973 2609910 Positive_regulation EPHB2 ZGLP1 22412973 2609915 Positive_regulation EPHB2 ZGLP1 22412973 2609916 Positive_regulation EPHB2 ZGLP1 22412973 2609921 Positive_regulation EPHB2 ZGLP1 22412973 2609922 Positive_regulation EPHB2 ZGLP1 22412973 2609923 Positive_regulation EPHB2 ZGLP1 22412973 2609927 Positive_regulation EPHB2 ZGLP1 22412973 2609928 Positive_regulation EPHB2 ZGLP1 22412973 2609930 Positive_regulation EPHB2 ZGLP1 22412973 2609931 Positive_regulation EPHB2 ZGLP1 24416433 2909112 Positive_regulation EPHB3 EFNB1 19025592 1897127 Positive_regulation EPHB3 EFNB1 20824214 2474178 Positive_regulation EPHB3 EFNB1 21390298 2275258 Positive_regulation EPHB3 EFNB1 23143520 1967850 Positive_regulation EPHB3 EFNB1 25473648 1713038 Positive_regulation EPHB4 EFNB1 19025592 1897128 Positive_regulation EPHB4 EFNB1 20824214 2474186 Positive_regulation EPHB4 EFNB1 21390298 2275261 Positive_regulation EPHB4 EFNB1 23143520 1967853 Positive_regulation EPHB4 EFNB1 25247423 2288169 Positive_regulation EPHB4 EFNB1 25473648 1713041 Positive_regulation EPHB4 EPHB2 25148033 3001315 Positive_regulation EPHB6 EFNB1 19025592 1897129 Positive_regulation EPHB6 EFNB1 20824214 2474194 Positive_regulation EPHB6 EFNB1 21390298 2275264 Positive_regulation EPHB6 EFNB1 23143520 1967856 Positive_regulation EPHB6 EFNB1 25473648 1713044 Positive_regulation EPO EPHB2 24416646 1708089 Positive_regulation EPO STK39 21994618 3219152 Positive_regulation EPO TNF 22394384 1661320 Positive_regulation EPOR EPHB2 22482061 1065192 Positive_regulation EPS15 CTGF 25384022 3024590 Positive_regulation EPS15 FUT4 23100020 1768438 Positive_regulation EPS15 PGC 20532042 2452245 Positive_regulation EPS15 RGS2 20135898 734802 Positive_regulation EPS8 CTGF 25384022 3024592 Positive_regulation EPS8 FUT4 23100020 1768449 Positive_regulation EPS8 PGC 20532042 2452246 Positive_regulation EPS8 RGS2 20135898 734803 Positive_regulation EPX EPHB2 21686182 1091060 Positive_regulation EPX EPHB2 21686182 1091061 Positive_regulation EPX EPHB2 21860424 2142213 Positive_regulation EPX EPHB2 21887333 2549336 Positive_regulation EPX RNASE1 21235798 3111940 Positive_regulation EPX RNASE7 21235798 3111948 Positive_regulation EPX S1PR3 21686182 1091058 Positive_regulation EPX TNF 17392570 1740591 Positive_regulation ERBB2 CCND1 21272329 586178 Positive_regulation ERBB2 EFNB1 22279592 2590850 Positive_regulation ERBB2 EPHB2 14623871 1301447 Positive_regulation ERBB2 EPHB2 15210733 1310113 Positive_regulation ERBB2 EPHB2 22649008 778727 Positive_regulation ERBB2 EPHB2 22988345 1750578 Positive_regulation ERBB2 F2R 24215724 538108 Positive_regulation ERBB2 F2R 24215724 538201 Positive_regulation ERBB2 F2R 24215724 538253 Positive_regulation ERBB2 HBEGF 22792252 2661667 Positive_regulation ERBB2 MMP28 18778487 384833 Positive_regulation ERBB2 MMP28 22318515 1988218 Positive_regulation ERBB2 MMP7 22318515 1988233 Positive_regulation ERBB2 PLAU 24709902 617312 Positive_regulation ERBB2 TMEM100 25137062 2999945 Positive_regulation ERBB2 TMEM156 25137062 2999963 Positive_regulation ERBB2 TMEM211 25137062 3000043 Positive_regulation ERBB2 TMEM213 25137062 2999980 Positive_regulation ERBB2 TNF 21386087 718839 Positive_regulation ERBB2 TNF 22157714 1717766 Positive_regulation ERBB2 TNF 22295219 1064955 Positive_regulation ERBB2 TNF 22482061 1065184 Positive_regulation ERBB3 EPHB2 24918976 620149 Positive_regulation ERBB3 FOXO1 22248929 2177369 Positive_regulation ERBB3 FOXO1 22248929 2177370 Positive_regulation ERBB3 MMP28 18778487 384849 Positive_regulation ERBB3 TNF 21386087 718840 Positive_regulation ERBB4 HBEGF 21946538 1961673 Positive_regulation ERBB4 HBEGF 23589494 1404534 Positive_regulation ERBB4 HBEGF 24071938 1112835 Positive_regulation ERBB4 HBEGF 24396465 2167500 Positive_regulation ERBB4 MMP28 20860838 466515 Positive_regulation ERBB4 MMP7 20860838 466530 Positive_regulation ERBB4 TNF 22157714 1717767 Positive_regulation ERC1 MMP28 22303396 882073 Positive_regulation ERC1 MMP7 22303396 882088 Positive_regulation ERC2 MMP28 22303396 882106 Positive_regulation ERC2 MMP7 22303396 882121 Positive_regulation ERC2 TUB 21573187 2522921 Positive_regulation EREG SPHK1 21936950 1697750 Positive_regulation EREG TNF 20161853 1043921 Positive_regulation EREG TNF 23826119 2810225 Positive_regulation ERF EPHB2 24168056 1700808 Positive_regulation ERG EPHB2 24504051 2187044 Positive_regulation ERG MAP2K6 21306619 332331 Positive_regulation ERLIN2 RNASE1 22681620 264828 Positive_regulation ERLIN2 RNASE7 22681620 264836 Positive_regulation ERN1 PGC 24167585 2872229 Positive_regulation ERN1 RNASE1 25520620 872734 Positive_regulation ERN1 RNASE7 25520620 872742 Positive_regulation ERN1 TLR7 20513765 1376540 Positive_regulation ERN1 TLR7 22125500 2327893 Positive_regulation ERN1 TLR7 22194844 2582904 Positive_regulation ERN1 TLR7 24387801 1162658 Positive_regulation ERN1 TLR7 24987391 926832 Positive_regulation ERN1 TLR7 25120559 896724 Positive_regulation ERN1 TNF 25530974 1496789 Positive_regulation ERVK-6 EPHB2 19144181 112405 Positive_regulation ERVK-6 EPHB2 19144181 112490 Positive_regulation ERVK-6 MAP2K6 19144181 112411 Positive_regulation ERVK-6 MAP2K6 19144181 112496 Positive_regulation ERVK-6 TNF 17047310 1212358 Positive_regulation ERVK-6 TNF 23403612 843008 Positive_regulation ERVW-1 TNF 22163338 3220667 Positive_regulation ESAT TNF 22523581 2620396 Positive_regulation ESAT TNF 22523581 2620397 Positive_regulation ESAT TNF 22523581 2620429 Positive_regulation ESD EPHB2 24710192 986093 Positive_regulation ESR1 CCND1 10390005 414580 Positive_regulation ESR1 CCND1 10682656 416199 Positive_regulation ESR1 CCND1 10901378 417273 Positive_regulation ESR1 CCND1 10953010 1262073 Positive_regulation ESR1 CCND1 25177151 454758 Positive_regulation ESR1 FOXA1 19405945 463789 Positive_regulation ESR1 IL1B 16842617 249520 Positive_regulation ESR1 SPHK1 25153718 2198617 Positive_regulation ESRRA PGC 18174917 2014021 Positive_regulation ETS1 ANGPT1 25329960 3017036 Positive_regulation ETS1 ANGPT1 25329960 3017122 Positive_regulation ETS1 CCND1 23383271 2749842 Positive_regulation ETS1 CTGF 16774692 106025 Positive_regulation ETS1 CTGF 22539964 2622625 Positive_regulation ETS1 EPHB2 15972796 2016770 Positive_regulation ETS1 EPHB2 17105652 106841 Positive_regulation ETS1 EPHB2 17105652 106842 Positive_regulation ETS1 EPHB2 17105652 106881 Positive_regulation ETS1 EPHB2 17105652 106997 Positive_regulation ETS1 EPHB2 24968297 2984151 Positive_regulation ETS1 EPHB2 25210949 1484877 Positive_regulation ETS1 EPHB2 25210949 1484882 Positive_regulation ETS1 EPHB2 25210949 1484885 Positive_regulation ETS1 EPHB2 25210949 1484891 Positive_regulation ETS1 EPHB2 25294825 2105210 Positive_regulation ETS1 MAP2K6 21167057 466978 Positive_regulation ETS1 MMP28 22971289 472105 Positive_regulation ETS1 MMP7 22971289 472125 Positive_regulation ETS1 PLAU 23724131 2799380 Positive_regulation ETS2 EPHB2 24968297 2984155 Positive_regulation ETS2 PLAU 23724131 2799381 Positive_regulation ETS2 TNF 19405951 113147 Positive_regulation ETS2 TNF 23789107 169887 Positive_regulation ETS2 TNF 23789107 169888 Positive_regulation ETS2 UCA1 24069250 2852280 Positive_regulation ETS2 UCA1 24069250 2852281 Positive_regulation ETV1 EPHB2 10424744 415033 Positive_regulation ETV4 EPHB2 21087211 148180 Positive_regulation ETV4 EPHB2 24287743 502469 Positive_regulation ETV4 EPHB2 24642271 1873202 Positive_regulation ETV5 EPHB2 21087211 148182 Positive_regulation ETV6 FOXO1 17010188 232453 Positive_regulation ETV7 ATR 25428364 2106788 Positive_regulation ETV7 ETV6 22291956 2591506 Positive_regulation ETV7 IL12A 25126585 1622898 Positive_regulation ETV7 IL12B 25126585 1622899 Positive_regulation ETV7 MED15 22291956 2591505 Positive_regulation ETV7 MED15 22291956 2591521 Positive_regulation EXD1 GLP1R 22438981 2612715 Positive_regulation EXD2 GLP1R 22438981 2612713 Positive_regulation EXD3 GLP1R 22438981 2612714 Positive_regulation EXOSC10 RNASE1 25200086 2104776 Positive_regulation EXOSC10 RNASE7 25200086 2104784 Positive_regulation EXOSC2 RNASE1 25200086 2104692 Positive_regulation EXOSC2 RNASE7 25200086 2104700 Positive_regulation EXOSC4 RNASE1 25200086 2104716 Positive_regulation EXOSC4 RNASE7 25200086 2104724 Positive_regulation EYA1 EPHB2 23251383 2727872 Positive_regulation EYA1 EPHB2 23251383 2728039 Positive_regulation EYA1 OSR1 23560233 85989 Positive_regulation EYA2 EPHB2 23251383 2727886 Positive_regulation EYA2 EPHB2 23251383 2728040 Positive_regulation EYA3 EPHB2 23251383 2727900 Positive_regulation EYA3 EPHB2 23251383 2728041 Positive_regulation EYA4 EPHB2 23251383 2727914 Positive_regulation EYA4 EPHB2 23251383 2728042 Positive_regulation EZH2 EPHB2 22948084 2180714 Positive_regulation EZH2 EPHB2 24168056 1700773 Positive_regulation EZH2 MAP2K6 22948084 2180720 Positive_regulation EZH2 TNF 20814569 2473458 Positive_regulation EZH2 TNF 22963717 472075 Positive_regulation EZH2 ZFP57 20808772 2472145 Positive_regulation EZR CAPN8 22073041 923743 Positive_regulation EZR CAPN8 22073041 923771 Positive_regulation EZR CAPN8 22073041 923799 Positive_regulation EZR CAPN8 9566966 1467244 Positive_regulation EZR CAPN8 9566966 1467245 Positive_regulation EZR CAPN8 9566966 1467319 Positive_regulation EZR CAPN8 9566966 1467407 Positive_regulation EZR EPHB2 23755307 2802612 Positive_regulation EZR PDZK1 20237154 1775200 Positive_regulation EZR PDZK1 20237154 1775204 Positive_regulation EZR PODXL 19889841 1770852 Positive_regulation EZR TSPAN1 21961047 2557441 Positive_regulation F11 HES2 20876311 1560389 Positive_regulation F12 TNF 22952837 2684254 Positive_regulation F2 F3 13006400 3228242 Positive_regulation F2 F3 13006400 3228243 Positive_regulation F2 F3 13006400 3228244 Positive_regulation F2 F3 14873922 1607816 Positive_regulation F2 F3 15431697 3228671 Positive_regulation F2 F3 15431697 3228673 Positive_regulation F2 F3 19732447 2234900 Positive_regulation F2 F3 24987614 89199 Positive_regulation F2 MUC16 20805935 515081 Positive_regulation F2 TNF 24728278 2951813 Positive_regulation F2R ABCC8 24829611 1650761 Positive_regulation F2R AHSA1 21029417 354070 Positive_regulation F2R APC 15969748 1695388 Positive_regulation F2R APC 16277710 658597 Positive_regulation F2R APC 17893198 1547100 Positive_regulation F2R APC 17893198 1547102 Positive_regulation F2R APC 18269690 658916 Positive_regulation F2R APC 18269690 658920 Positive_regulation F2R APC 19922636 3178026 Positive_regulation F2R APC 20804552 1626155 Positive_regulation F2R APC 21834973 659976 Positive_regulation F2R APC 21834973 659978 Positive_regulation F2R APC 22017971 660079 Positive_regulation F2R APC 22355515 2235754 Positive_regulation F2R APC 23448515 660406 Positive_regulation F2R APC 24733067 1126061 Positive_regulation F2R APC 25313362 201329 Positive_regulation F2R ARHGEF1 15899034 102765 Positive_regulation F2R CA1 20875131 1897685 Positive_regulation F2R CA2 21827709 1835927 Positive_regulation F2R CA2 21827709 1835928 Positive_regulation F2R CA2 21827709 1835933 Positive_regulation F2R CA2 24321245 1842796 Positive_regulation F2R CA2 24860547 880598 Positive_regulation F2R CA2 8642286 1596691 Positive_regulation F2R CCL2 21760880 2535636 Positive_regulation F2R CCL2 22992722 988786 Positive_regulation F2R CCL2 24015257 2842545 Positive_regulation F2R CCL2 24475094 2914738 Positive_regulation F2R CCL2 24624928 511372 Positive_regulation F2R CCL2 24927773 3102520 Positive_regulation F2R CCNC 21134286 1696917 Positive_regulation F2R CISH 22731117 1663847 Positive_regulation F2R CTNND1 19917775 1556770 Positive_regulation F2R CTSG 19948715 805355 Positive_regulation F2R CYR61 25407528 1134481 Positive_regulation F2R DAPK1 24860424 931899 Positive_regulation F2R DAPK2 24860424 931900 Positive_regulation F2R DAPK3 24860424 931901 Positive_regulation F2R DLEU1 22992722 988767 Positive_regulation F2R DLEU2 22992722 988768 Positive_regulation F2R DLEU7 22992722 988769 Positive_regulation F2R DVL1 PMC2756345 496062 Positive_regulation F2R DVL2 PMC2756345 496063 Positive_regulation F2R DVL3 PMC2756345 496064 Positive_regulation F2R ECM1 21966428 2557695 Positive_regulation F2R ECM2 21966428 2557696 Positive_regulation F2R EGFR 24215724 538109 Positive_regulation F2R EGFR 24215724 538255 Positive_regulation F2R EGFR 24385683 1756355 Positive_regulation F2R EGFR 24385683 1756375 Positive_regulation F2R ELANE 21209875 2491649 Positive_regulation F2R ELANE 25313362 201328 Positive_regulation F2R EPHB2 17319972 1645307 Positive_regulation F2R ERBB2 24215724 538110 Positive_regulation F2R ERBB2 24215724 538256 Positive_regulation F2R ERVK-6 22072823 1713184 Positive_regulation F2R F10 22072823 1713185 Positive_regulation F2R F10 24215724 538202 Positive_regulation F2R F2RL1 12720558 658475 Positive_regulation F2R F2RL1 22731117 1663843 Positive_regulation F2R F2RL1 24043563 646064 Positive_regulation F2R F2RL1 24062581 2250348 Positive_regulation F2R F2RL1 24215724 538127 Positive_regulation F2R F2RL1 24215724 538203 Positive_regulation F2R F2RL1 24278684 3150075 Positive_regulation F2R F2RL2 20350296 1995263 Positive_regulation F2R F2RL3 19948715 805356 Positive_regulation F2R F2RL3 21721170 29564 Positive_regulation F2R F2RL3 24453410 1756644 Positive_regulation F2R F2RL3 25407528 1134482 Positive_regulation F2R F7 22072823 1713186 Positive_regulation F2R FOSL1 21966428 2557705 Positive_regulation F2R GP6 23986721 962068 Positive_regulation F2R GRK1 21760880 2535400 Positive_regulation F2R GRK1 21760880 2535401 Positive_regulation F2R GRK1 21760880 2535635 Positive_regulation F2R GRK1 21760880 2535893 Positive_regulation F2R GRK4 21760880 2535404 Positive_regulation F2R GRK4 21760880 2535405 Positive_regulation F2R GRK4 21760880 2535640 Positive_regulation F2R GRK4 21760880 2535895 Positive_regulation F2R GRK5 21760880 2535406 Positive_regulation F2R GRK5 21760880 2535407 Positive_regulation F2R GRK5 21760880 2535641 Positive_regulation F2R GRK5 21760880 2535896 Positive_regulation F2R GRK6 21760880 2535408 Positive_regulation F2R GRK6 21760880 2535409 Positive_regulation F2R GRK6 21760880 2535642 Positive_regulation F2R GRK6 21760880 2535897 Positive_regulation F2R GRK7 21760880 2535402 Positive_regulation F2R GRK7 21760880 2535403 Positive_regulation F2R GRK7 21760880 2535637 Positive_regulation F2R GRK7 21760880 2535894 Positive_regulation F2R GTPBP1 23986721 962087 Positive_regulation F2R HGF 24927773 3102521 Positive_regulation F2R ICAM1 24624928 511373 Positive_regulation F2R IL12A 24015257 2842546 Positive_regulation F2R IL12B 24015257 2842547 Positive_regulation F2R IL1A 16808851 1654914 Positive_regulation F2R IL1A 19852794 1227706 Positive_regulation F2R IL1A 19852794 1227761 Positive_regulation F2R IL1A 19852794 1227778 Positive_regulation F2R IL6 24015257 2842550 Positive_regulation F2R IL8 21760880 2535643 Positive_regulation F2R IL8 24876677 1758990 Positive_regulation F2R IL8 25061982 2992601 Positive_regulation F2R JUN 21966428 2557706 Positive_regulation F2R KLK1 24043563 646065 Positive_regulation F2R KLK14 24043563 646066 Positive_regulation F2R KLK2 24043563 646067 Positive_regulation F2R KLK4 24043563 646068 Positive_regulation F2R KLK6 21464892 2510275 Positive_regulation F2R LGALS3 21966428 2557677 Positive_regulation F2R LGALS3 21966428 2557678 Positive_regulation F2R LGALS3 21966428 2557679 Positive_regulation F2R LGALS3 21966428 2557680 Positive_regulation F2R LGALS3 21966428 2557697 Positive_regulation F2R LGALS3 21966428 2557707 Positive_regulation F2R MAPK1 21760880 2535644 Positive_regulation F2R MAPK1 24215724 538257 Positive_regulation F2R MAPK10 21760880 2535645 Positive_regulation F2R MAPK10 24215724 538258 Positive_regulation F2R MAPK11 21760880 2535646 Positive_regulation F2R MAPK11 24215724 538259 Positive_regulation F2R MAPK12 21760880 2535647 Positive_regulation F2R MAPK12 24215724 538260 Positive_regulation F2R MAPK13 21760880 2535648 Positive_regulation F2R MAPK13 24215724 538261 Positive_regulation F2R MAPK14 21760880 2535649 Positive_regulation F2R MAPK14 24215724 538262 Positive_regulation F2R MAPK15 21760880 2535639 Positive_regulation F2R MAPK15 24215724 538254 Positive_regulation F2R MAPK3 21029417 354071 Positive_regulation F2R MAPK3 21029417 354160 Positive_regulation F2R MAPK3 21760880 2535650 Positive_regulation F2R MAPK3 21760880 2535826 Positive_regulation F2R MAPK3 24215724 538263 Positive_regulation F2R MAPK4 21760880 2535651 Positive_regulation F2R MAPK4 24215724 538264 Positive_regulation F2R MAPK6 21760880 2535652 Positive_regulation F2R MAPK6 24215724 538265 Positive_regulation F2R MAPK7 21760880 2535653 Positive_regulation F2R MAPK7 24215724 538266 Positive_regulation F2R MAPK8 21760880 2535654 Positive_regulation F2R MAPK8 24215724 538267 Positive_regulation F2R MAPK9 21760880 2535655 Positive_regulation F2R MAPK9 24215724 538268 Positive_regulation F2R MBTPS1 22482044 661516 Positive_regulation F2R MED1 10662791 1514275 Positive_regulation F2R MED1 21134286 1696929 Positive_regulation F2R MED10 21134286 1696928 Positive_regulation F2R MED12 10662791 1514269 Positive_regulation F2R MED12 21134286 1696916 Positive_regulation F2R MED13 21134286 1696921 Positive_regulation F2R MED14 10662791 1514273 Positive_regulation F2R MED14 21134286 1696924 Positive_regulation F2R MED16 10662791 1514270 Positive_regulation F2R MED16 21134286 1696918 Positive_regulation F2R MED17 10662791 1514274 Positive_regulation F2R MED17 21134286 1696925 Positive_regulation F2R MED21 21134286 1696914 Positive_regulation F2R MED24 10662791 1514271 Positive_regulation F2R MED24 21134286 1696922 Positive_regulation F2R MED27 21134286 1696926 Positive_regulation F2R MED31 21134286 1696927 Positive_regulation F2R MED4 21134286 1696919 Positive_regulation F2R MED6 21134286 1696920 Positive_regulation F2R MET 25386346 3092729 Positive_regulation F2R MIF 21209875 2491645 Positive_regulation F2R MIF 24876677 1759031 Positive_regulation F2R MMP1 19734937 2126737 Positive_regulation F2R MMP1 19734937 2126741 Positive_regulation F2R MMP1 19734937 2126742 Positive_regulation F2R MMP1 19734937 2126752 Positive_regulation F2R MMP1 19734937 2126759 Positive_regulation F2R MMP1 19734937 2126763 Positive_regulation F2R MMP1 20559570 2453158 Positive_regulation F2R MMP1 21318117 2234223 Positive_regulation F2R MMP1 21591259 776191 Positive_regulation F2R MMP1 21591259 776197 Positive_regulation F2R MMP1 21591259 776198 Positive_regulation F2R MMP1 21591259 776200 Positive_regulation F2R MMP1 21591259 776224 Positive_regulation F2R MMP1 21966428 2557681 Positive_regulation F2R MMP1 21966428 2557682 Positive_regulation F2R MMP1 21966428 2557698 Positive_regulation F2R MMP1 22086466 453001 Positive_regulation F2R MMP1 22992722 988758 Positive_regulation F2R MMP1 22992722 988759 Positive_regulation F2R MMP1 22992722 988760 Positive_regulation F2R MMP1 22992722 988770 Positive_regulation F2R MMP1 22992722 988775 Positive_regulation F2R MMP1 22992722 988787 Positive_regulation F2R MMP1 23217186 267192 Positive_regulation F2R MMP1 23675494 2793352 Positive_regulation F2R MMP1 23675494 2793355 Positive_regulation F2R MMP1 23675494 2793358 Positive_regulation F2R MMP1 23889169 213828 Positive_regulation F2R MMP1 24384839 1122806 Positive_regulation F2R MMP1 24860547 880623 Positive_regulation F2R MMP13 24385683 1756376 Positive_regulation F2R MMP13 24860547 880652 Positive_regulation F2R MMP13 25313362 201340 Positive_regulation F2R MMP2 23675494 2793353 Positive_regulation F2R MMP2 23675494 2793356 Positive_regulation F2R MMP3 21331154 2232282 Positive_regulation F2R MMP9 24876677 1758991 Positive_regulation F2R P2RX1 23986721 962070 Positive_regulation F2R P2RY1 23125832 873282 Positive_regulation F2R P2RY1 23986721 962071 Positive_regulation F2R P2RY12 23986721 962069 Positive_regulation F2R PAGR1 23300803 2736043 Positive_regulation F2R PARD3 22731117 1663838 Positive_regulation F2R PARD6A 20350296 1995262 Positive_regulation F2R PAWR 24043563 646069 Positive_regulation F2R PAWR 24860547 880599 Positive_regulation F2R PDGFRB 24215724 538220 Positive_regulation F2R PLAT 25604482 3149714 Positive_regulation F2R PLG 23097597 1225249 Positive_regulation F2R PLG 23125522 1225544 Positive_regulation F2R POLDIP2 21029417 354127 Positive_regulation F2R POLDIP2 21760880 2535638 Positive_regulation F2R PPP2CA 24829611 1650762 Positive_regulation F2R PPP2R1A 24829611 1650763 Positive_regulation F2R PPP2R2B 24829611 1650764 Positive_regulation F2R PROC 15665396 735929 Positive_regulation F2R PROC 17480240 279746 Positive_regulation F2R PROC 24152910 220916 Positive_regulation F2R PROC 24215724 538221 Positive_regulation F2R PROCR 17893198 1547103 Positive_regulation F2R PTAFR 23448515 660407 Positive_regulation F2R PTGS2 24927773 3102522 Positive_regulation F2R PTX3 24743392 2955406 Positive_regulation F2R PTX4 24743392 2955405 Positive_regulation F2R RHOA 23949634 1109815 Positive_regulation F2R S1PR1 22482044 661517 Positive_regulation F2R SHH 25386346 3092728 Positive_regulation F2R SLC22A3 23919450 834025 Positive_regulation F2R SLC2A4RG 15899034 102764 Positive_regulation F2R SOCS3 22731117 1663849 Positive_regulation F2R ST14 22518344 1082541 Positive_regulation F2R STK11 22545229 3163552 Positive_regulation F2R STK11 23940457 2283787 Positive_regulation F2R STK11 23940457 2283795 Positive_regulation F2R TAOK2 23940457 2283788 Positive_regulation F2R TFAP2A 20936327 494132 Positive_regulation F2R TFPI 23320987 1617678 Positive_regulation F2R THRA 10662791 1514268 Positive_regulation F2R THRA 21134286 1696915 Positive_regulation F2R THRAP3 10662791 1514272 Positive_regulation F2R THRAP3 21134286 1696923 Positive_regulation F2R TNF 24453410 1756646 Positive_regulation F2R TNF 24876677 1759030 Positive_regulation F2R TXNDC17 8383691 1447818 Positive_regulation F2RL1 EPHB2 24084727 1113087 Positive_regulation F2RL1 EPHB2 24084727 1113105 Positive_regulation F2RL1 F2R 17705868 351943 Positive_regulation F2RL1 F2R 21029417 353993 Positive_regulation F2RL1 F2R 24062581 2250349 Positive_regulation F2RL1 F2R 24215724 538128 Positive_regulation F2RL1 F2R 24215724 538129 Positive_regulation F2RL1 F2R 24215724 538205 Positive_regulation F2RL1 F2R 24860547 880624 Positive_regulation F2RL1 F2R 25364818 3021837 Positive_regulation F2RL1 TNF 16571116 1624880 Positive_regulation F2RL1 TNF 19414552 1554720 Positive_regulation F2RL1 TNF 19852794 1227785 Positive_regulation F2RL1 TNF 24876677 1759032 Positive_regulation F2RL1 TNF 24876677 1759041 Positive_regulation F2RL2 KRT38 24860547 880625 Positive_regulation F2RL3 F2R 17705868 351944 Positive_regulation F2RL3 F2R 21134286 1696931 Positive_regulation F2RL3 F2R 22731117 1663841 Positive_regulation F2RL3 F2R 25407528 1134483 Positive_regulation F2RL3 TNF 24876677 1759035 Positive_regulation F2RL3 TNF 24876677 1759045 Positive_regulation F2RL3 TNFSF10 24795528 1062773 Positive_regulation F3 CISH 7500026 1587201 Positive_regulation F3 CPB1 24717423 219428 Positive_regulation F3 CPB2 24717423 219429 Positive_regulation F3 CSF1 19773616 736323 Positive_regulation F3 DPP4 22167343 142815 Positive_regulation F3 DPP4 22167343 142838 Positive_regulation F3 F2 15431697 3228672 Positive_regulation F3 F2 15431697 3228674 Positive_regulation F3 F2R 22167343 142821 Positive_regulation F3 NOX1 22167343 142822 Positive_regulation F3 NOX3 22167343 142823 Positive_regulation F3 NOX4 22167343 142824 Positive_regulation F3 NOX5 22167343 142820 Positive_regulation F3 RENBP 15203887 830986 Positive_regulation F3 TNF 3753996 1583650 Positive_regulation F3 VEGFA 18293091 86798 Positive_regulation F7 CTGF 11673116 790176 Positive_regulation F8 TNF 25422582 743483 Positive_regulation F9 EPHB2 25076890 515686 Positive_regulation F9 MAP2K6 25076890 515692 Positive_regulation FABP1 FAS 15869703 2112238 Positive_regulation FABP1 FAS 19725974 310830 Positive_regulation FABP1 FAS 22776158 312087 Positive_regulation FABP1 FAS 23284658 2730396 Positive_regulation FABP1 FOXO1 22997544 2224932 Positive_regulation FABP12 FAS 15869703 2112237 Positive_regulation FABP12 FAS 19725974 310829 Positive_regulation FABP12 FAS 22776158 312086 Positive_regulation FABP12 FAS 23284658 2730395 Positive_regulation FABP12 FOXO1 22997544 2224928 Positive_regulation FABP2 FAS 15869703 2112239 Positive_regulation FABP2 FAS 19725974 310831 Positive_regulation FABP2 FAS 22776158 312088 Positive_regulation FABP2 FAS 23284658 2730397 Positive_regulation FABP2 FOXO1 22997544 2224936 Positive_regulation FABP3 FAS 15869703 2112240 Positive_regulation FABP3 FAS 19725974 310832 Positive_regulation FABP3 FAS 22776158 312089 Positive_regulation FABP3 FAS 23284658 2730398 Positive_regulation FABP3 FOXO1 22997544 2224940 Positive_regulation FABP4 EPHB2 25325755 1638185 Positive_regulation FABP4 FAS 15869703 2112241 Positive_regulation FABP4 FAS 19725974 310833 Positive_regulation FABP4 FAS 22776158 312090 Positive_regulation FABP4 FAS 23284658 2730399 Positive_regulation FABP4 FOXO1 22121495 1082407 Positive_regulation FABP4 FOXO1 22997544 2224944 Positive_regulation FABP4 FOXO1 23620761 2783311 Positive_regulation FABP4 PGC 23236470 2726518 Positive_regulation FABP4 TLR7 20652007 1747481 Positive_regulation FABP5 FAS 15869703 2112242 Positive_regulation FABP5 FAS 19725974 310834 Positive_regulation FABP5 FAS 22776158 312091 Positive_regulation FABP5 FAS 23284658 2730400 Positive_regulation FABP5 FOXO1 22997544 2224948 Positive_regulation FABP5 S100A7 20500888 411794 Positive_regulation FABP6 FAS 15869703 2112243 Positive_regulation FABP6 FAS 19725974 310835 Positive_regulation FABP6 FAS 22776158 312092 Positive_regulation FABP6 FAS 23284658 2730401 Positive_regulation FABP6 FOXO1 22997544 2224952 Positive_regulation FABP7 FAS 15869703 2112244 Positive_regulation FABP7 FAS 19725974 310836 Positive_regulation FABP7 FAS 22776158 312093 Positive_regulation FABP7 FAS 23284658 2730402 Positive_regulation FABP7 FOXO1 22997544 2224956 Positive_regulation FABP7 JAG1 21078177 358131 Positive_regulation FABP7 NR2F1 20111703 2438543 Positive_regulation FABP9 FAS 15869703 2112245 Positive_regulation FABP9 FAS 19725974 310837 Positive_regulation FABP9 FAS 22776158 312094 Positive_regulation FABP9 FAS 23284658 2730403 Positive_regulation FABP9 FOXO1 22997544 2224960 Positive_regulation FADD FAS 10839812 1515698 Positive_regulation FADD FAS 19118384 1983116 Positive_regulation FADD FAS 22361748 554974 Positive_regulation FADD FAS 22474531 814134 Positive_regulation FADD FAS 23935974 2828798 Positive_regulation FADD TNF 19373245 546129 Positive_regulation FADD TNF 21307340 1786593 Positive_regulation FADD TNFSF10 18992144 251773 Positive_regulation FADD TNFSF10 23365613 817256 Positive_regulation FAH TNF 1911180 431519 Positive_regulation FAH TNF 1989668 433968 Positive_regulation FAIM2 EPHB2 23029562 2698761 Positive_regulation FAIM2 EPHB2 23029562 2698784 Positive_regulation FAIM2 EPHB2 23029562 2698785 Positive_regulation FAIM2 EPHB2 23029562 2698815 Positive_regulation FAIM2 EPHB2 23029562 2698816 Positive_regulation FAIM2 EPHB2 23029562 2698837 Positive_regulation FAIM2 EPHB2 23029562 2698838 Positive_regulation FAIM2 FAS 23029562 2698760 Positive_regulation FAIM2 FAS 23029562 2698778 Positive_regulation FAIM2 FAS 23029562 2698782 Positive_regulation FAIM2 FAS 23029562 2698783 Positive_regulation FAIM2 FAS 23029562 2698836 Positive_regulation FAIM3 CHI3L1 19414556 1554750 Positive_regulation FAM65B FOXO1 25330112 3017204 Positive_regulation FAM65B MFI2 21190562 1860635 Positive_regulation FANCA STAT4 21826217 2540977 Positive_regulation FANCC SELL 22675617 86521 Positive_regulation FANCE SELL 22675617 86523 Positive_regulation FAP MYH16 20223042 1029791 Positive_regulation FAP MYH3 20223042 1029798 Positive_regulation FAS ACACA 22956916 2338240 Positive_regulation FAS ACACA 24058537 2847899 Positive_regulation FAS ACACA 24367387 824834 Positive_regulation FAS ACSS1 24284429 1730414 Positive_regulation FAS ACSS2 24284429 1730413 Positive_regulation FAS ACSS3 24284429 1730415 Positive_regulation FAS AHR 21858153 2546661 Positive_regulation FAS AHR 22951985 557650 Positive_regulation FAS AHR 23533402 1693728 Positive_regulation FAS AKT1 19936232 2431768 Positive_regulation FAS AKT1 19936232 2431769 Positive_regulation FAS AKT1 19936232 2431796 Positive_regulation FAS AKT1 19936232 2431801 Positive_regulation FAS AKT1 22824368 1724869 Positive_regulation FAS AKT1 22824368 1724881 Positive_regulation FAS AKT1S1 23676995 589634 Positive_regulation FAS AKT2 19936232 2431770 Positive_regulation FAS AKT2 19936232 2431771 Positive_regulation FAS AKT2 19936232 2431797 Positive_regulation FAS AKT2 19936232 2431802 Positive_regulation FAS AKT2 22824368 1724870 Positive_regulation FAS AKT3 19936232 2431772 Positive_regulation FAS AKT3 19936232 2431773 Positive_regulation FAS AKT3 19936232 2431798 Positive_regulation FAS AKT3 19936232 2431803 Positive_regulation FAS AKT3 22824368 1724871 Positive_regulation FAS ANGPT1 23250359 725426 Positive_regulation FAS ANGPT2 21131996 12193 Positive_regulation FAS APOB 24062611 1754758 Positive_regulation FAS ARG1 24025841 1990941 Positive_regulation FAS ARG2 24025841 1990942 Positive_regulation FAS ARHGEF2 25107365 1488249 Positive_regulation FAS ARHGEF2 25107365 1488250 Positive_regulation FAS ATG7 22540380 264589 Positive_regulation FAS BANF1 22046349 2566519 Positive_regulation FAS BANF1 22046349 2566766 Positive_regulation FAS BAX 23304518 1496963 Positive_regulation FAS BAX 23901269 1137731 Positive_regulation FAS BCAP31 12668660 1291749 Positive_regulation FAS BCL2 10993919 1517298 Positive_regulation FAS BCL2 20360925 652779 Positive_regulation FAS BCL2 22694839 406240 Positive_regulation FAS BCL2 23468852 2759831 Positive_regulation FAS BECN1 22540380 264586 Positive_regulation FAS BHLHE41 18838394 2036719 Positive_regulation FAS BRCA1 25594018 2173726 Positive_regulation FAS BRCA1 25594018 2173731 Positive_regulation FAS C9orf3 18715501 166120 Positive_regulation FAS C9orf3 22389673 2607917 Positive_regulation FAS CA2 21713032 2276630 Positive_regulation FAS CA2 24778996 3188208 Positive_regulation FAS CA2 9529322 1602583 Positive_regulation FAS CASP1 11806838 3103614 Positive_regulation FAS CASP1 17286612 32446 Positive_regulation FAS CASP1 18516228 3041473 Positive_regulation FAS CASP1 22221539 1651301 Positive_regulation FAS CASP1 8655577 1451786 Positive_regulation FAS CASP1 9730899 1603721 Positive_regulation FAS CASP10 17286612 32447 Positive_regulation FAS CASP10 18516228 3041474 Positive_regulation FAS CASP10 21049020 2480430 Positive_regulation FAS CASP10 21368896 551250 Positive_regulation FAS CASP10 21368896 551252 Positive_regulation FAS CASP10 23211670 1099937 Positive_regulation FAS CASP10 9730899 1603722 Positive_regulation FAS CASP12 17286612 32457 Positive_regulation FAS CASP12 18516228 3041484 Positive_regulation FAS CASP12 9730899 1603733 Positive_regulation FAS CASP14 17286612 32448 Positive_regulation FAS CASP14 18516228 3041475 Positive_regulation FAS CASP14 9730899 1603723 Positive_regulation FAS CASP16 17286612 32458 Positive_regulation FAS CASP16 18516228 3041485 Positive_regulation FAS CASP16 9730899 1603734 Positive_regulation FAS CASP2 17286612 32449 Positive_regulation FAS CASP2 18516228 3041476 Positive_regulation FAS CASP2 9730899 1603724 Positive_regulation FAS CASP3 11806838 3103615 Positive_regulation FAS CASP3 14738570 277398 Positive_regulation FAS CASP3 17286612 32450 Positive_regulation FAS CASP3 18516228 3041477 Positive_regulation FAS CASP3 20358022 35589 Positive_regulation FAS CASP3 21331284 1680360 Positive_regulation FAS CASP3 23181119 842712 Positive_regulation FAS CASP3 23211670 1099938 Positive_regulation FAS CASP3 23358309 1684705 Positive_regulation FAS CASP3 23372841 2746216 Positive_regulation FAS CASP3 24380387 271030 Positive_regulation FAS CASP3 25003395 504991 Positive_regulation FAS CASP3 25072848 2993050 Positive_regulation FAS CASP3 9730899 1603725 Positive_regulation FAS CASP4 17286612 32451 Positive_regulation FAS CASP4 18516228 3041478 Positive_regulation FAS CASP4 9730899 1603726 Positive_regulation FAS CASP5 17286612 32452 Positive_regulation FAS CASP5 18516228 3041479 Positive_regulation FAS CASP5 9730899 1603727 Positive_regulation FAS CASP6 17286612 32453 Positive_regulation FAS CASP6 18516228 3041480 Positive_regulation FAS CASP6 9730899 1603728 Positive_regulation FAS CASP7 17286612 32454 Positive_regulation FAS CASP7 18516228 3041481 Positive_regulation FAS CASP7 9730899 1603729 Positive_regulation FAS CASP8 12495445 656276 Positive_regulation FAS CASP8 14577831 3095114 Positive_regulation FAS CASP8 14960210 656460 Positive_regulation FAS CASP8 15795317 1319321 Positive_regulation FAS CASP8 17286612 32455 Positive_regulation FAS CASP8 18516228 3041482 Positive_regulation FAS CASP8 18925930 659066 Positive_regulation FAS CASP8 20358022 35590 Positive_regulation FAS CASP8 21368876 550935 Positive_regulation FAS CASP8 21654827 552289 Positive_regulation FAS CASP8 21911424 1565334 Positive_regulation FAS CASP8 22540380 264588 Positive_regulation FAS CASP8 22675349 1073056 Positive_regulation FAS CASP8 22978358 3215093 Positive_regulation FAS CASP8 23181119 842713 Positive_regulation FAS CASP8 23372841 2746217 Positive_regulation FAS CASP8 23468852 2759830 Positive_regulation FAS CASP8 23584398 218451 Positive_regulation FAS CASP8 23940767 2832344 Positive_regulation FAS CASP8 24578682 938690 Positive_regulation FAS CASP8 25072848 2993051 Positive_regulation FAS CASP8 9206994 1601251 Positive_regulation FAS CASP8 9730899 1603730 Positive_regulation FAS CASP8 9730899 1603731 Positive_regulation FAS CASP9 10839799 1515555 Positive_regulation FAS CASP9 17286612 32456 Positive_regulation FAS CASP9 18516228 3041483 Positive_regulation FAS CASP9 25072848 2993052 Positive_regulation FAS CASP9 9730899 1603732 Positive_regulation FAS CAV1 25202343 2169598 Positive_regulation FAS CBL 23349502 725968 Positive_regulation FAS CCL4 23243434 816498 Positive_regulation FAS CCL4 23374533 2113853 Positive_regulation FAS CCNG1 23908786 3092573 Positive_regulation FAS CD1D 22837759 902645 Positive_regulation FAS CD27 22837759 902644 Positive_regulation FAS CD28 20815894 1504475 Positive_regulation FAS CD3D 7530763 1589955 Positive_regulation FAS CD3D 9396757 1465240 Positive_regulation FAS CD3E 7530763 1589956 Positive_regulation FAS CD3E 9396757 1465241 Positive_regulation FAS CD3G 7530763 1589957 Positive_regulation FAS CD3G 9396757 1465242 Positive_regulation FAS CD4 22177276 1630008 Positive_regulation FAS CD40 12860928 1527855 Positive_regulation FAS CD40 16545138 249263 Positive_regulation FAS CD40 17225862 2374554 Positive_regulation FAS CD40 17562816 1546357 Positive_regulation FAS CD40 22194871 2582992 Positive_regulation FAS CD40 22848207 902687 Positive_regulation FAS CD40 25117071 3205378 Positive_regulation FAS CD40 7519240 1589378 Positive_regulation FAS CD40 7595197 1590741 Positive_regulation FAS CD40 7595197 1590742 Positive_regulation FAS CD40 7595197 1590743 Positive_regulation FAS CD40 7595197 1590745 Positive_regulation FAS CD40 7595197 1590746 Positive_regulation FAS CD40 7595197 1590747 Positive_regulation FAS CD40 7595225 1590950 Positive_regulation FAS CD40 7595225 1590969 Positive_regulation FAS CD40 7595225 1590971 Positive_regulation FAS CD40 8551247 1595976 Positive_regulation FAS CD40 8551247 1595977 Positive_regulation FAS CD40 8642300 1596781 Positive_regulation FAS CD40 8691124 1598041 Positive_regulation FAS CD40 9064343 1600343 Positive_regulation FAS CD40 9064343 1600344 Positive_regulation FAS CD40 9064343 1600345 Positive_regulation FAS CD40 9064343 1600356 Positive_regulation FAS CD40 9064343 1600357 Positive_regulation FAS CD40 9064343 1600358 Positive_regulation FAS CD40 9221764 1601322 Positive_regulation FAS CD40 9221764 1601323 Positive_regulation FAS CD40 9221764 1601330 Positive_regulation FAS CD40 9221764 1601331 Positive_regulation FAS CD40 9683298 447466 Positive_regulation FAS CD40 9683298 447467 Positive_regulation FAS CD40 9683298 447468 Positive_regulation FAS CD40 9683298 447472 Positive_regulation FAS CD40 9683298 447473 Positive_regulation FAS CD40LG 12860928 1527838 Positive_regulation FAS CD40LG 17562816 1546358 Positive_regulation FAS CD40LG 22848207 902688 Positive_regulation FAS CD40LG 22848207 902705 Positive_regulation FAS CD40LG 7595225 1590951 Positive_regulation FAS CD40LG 7595225 1590972 Positive_regulation FAS CD40LG 9064343 1600346 Positive_regulation FAS CD40LG 9064343 1600363 Positive_regulation FAS CD40LG 9683298 447470 Positive_regulation FAS CD40LG PMC2062908 448326 Positive_regulation FAS CD5 22837759 902646 Positive_regulation FAS CD74 25304249 1510815 Positive_regulation FAS CD8A 21107637 599701 Positive_regulation FAS CD8A 23091461 959472 Positive_regulation FAS CD8B 21107637 599702 Positive_regulation FAS CD8B 23091461 959473 Positive_regulation FAS CDKN1A 9472635 446881 Positive_regulation FAS CFLAR 22203854 1155954 Positive_regulation FAS CFLAR 22348197 497092 Positive_regulation FAS CFLAR 22875006 557322 Positive_regulation FAS CFLAR 25379355 1243450 Positive_regulation FAS CISH 24024882 316811 Positive_regulation FAS CNOT6 24469038 2154626 Positive_regulation FAS CNR1 22334255 2119368 Positive_regulation FAS CNTNAP1 10769036 1257223 Positive_regulation FAS COA1 22348016 2596438 Positive_regulation FAS COA1 23762027 3062308 Positive_regulation FAS COA1 24040277 2846341 Positive_regulation FAS COA1 25045276 645406 Positive_regulation FAS COA1 25198467 3006008 Positive_regulation FAS COA3 22348016 2596440 Positive_regulation FAS COA3 23762027 3062310 Positive_regulation FAS COA3 24040277 2846343 Positive_regulation FAS COA3 25045276 645408 Positive_regulation FAS COA3 25198467 3006010 Positive_regulation FAS COA4 22348016 2596439 Positive_regulation FAS COA4 23762027 3062309 Positive_regulation FAS COA4 24040277 2846342 Positive_regulation FAS COA4 25045276 645407 Positive_regulation FAS COA4 25198467 3006009 Positive_regulation FAS COA5 22348016 2596441 Positive_regulation FAS COA5 23762027 3062311 Positive_regulation FAS COA5 24040277 2846344 Positive_regulation FAS COA5 25045276 645409 Positive_regulation FAS COA5 25198467 3006011 Positive_regulation FAS COA6 22348016 2596437 Positive_regulation FAS COA6 23762027 3062307 Positive_regulation FAS COA6 24040277 2846340 Positive_regulation FAS COA6 25045276 645405 Positive_regulation FAS COA6 25198467 3006007 Positive_regulation FAS CPB1 24386164 2902935 Positive_regulation FAS CPB2 24386164 2902936 Positive_regulation FAS CPE 21779520 2115020 Positive_regulation FAS CPT1A 24379011 2118399 Positive_regulation FAS CR2 22848207 902719 Positive_regulation FAS CSF1 22479263 1993340 Positive_regulation FAS CTLA4 24677194 1029692 Positive_regulation FAS CXCR4 25196285 3224082 Positive_regulation FAS DAXX 15123887 1212206 Positive_regulation FAS DES 22087162 1028601 Positive_regulation FAS DES 23060697 2247870 Positive_regulation FAS DISC1 12163562 1524393 Positive_regulation FAS DISC1 23404198 93264 Positive_regulation FAS DISC2 12163562 1524394 Positive_regulation FAS DISC2 23404198 93265 Positive_regulation FAS DLG1 18070911 1346796 Positive_regulation FAS DLG1 18070911 1346813 Positive_regulation FAS DLG2 18070911 1346797 Positive_regulation FAS DLG2 18070911 1346814 Positive_regulation FAS DLG3 18070911 1346798 Positive_regulation FAS DLG3 18070911 1346815 Positive_regulation FAS DLG4 18070911 1346799 Positive_regulation FAS DLG4 18070911 1346816 Positive_regulation FAS DLG5 18070911 1346800 Positive_regulation FAS DLG5 18070911 1346817 Positive_regulation FAS DST 22403704 2609152 Positive_regulation FAS ECM1 1691191 1332156 Positive_regulation FAS ECM1 24065163 1730253 Positive_regulation FAS ECM1 24065163 1730283 Positive_regulation FAS ECM1 24859005 1930770 Positive_regulation FAS ECM2 1691191 1332157 Positive_regulation FAS ECM2 24065163 1730254 Positive_regulation FAS ECM2 24065163 1730284 Positive_regulation FAS ECM2 24859005 1930771 Positive_regulation FAS EGF 22046349 2566520 Positive_regulation FAS EGF 23762063 1069289 Positive_regulation FAS EGFR 19032775 1005299 Positive_regulation FAS EGFR 24212818 498631 Positive_regulation FAS EIF2AK2 22174754 2581084 Positive_regulation FAS EIF2AK2 25196936 1730918 Positive_regulation FAS EPAS1 21869830 547462 Positive_regulation FAS EPHB2 22046349 2566521 Positive_regulation FAS ERBB2 PMC4233553 477204 Positive_regulation FAS ERBB2 PMC4233553 477206 Positive_regulation FAS ESR1 9841917 1604739 Positive_regulation FAS EZR 16365167 1326365 Positive_regulation FAS EZR 16365167 1326374 Positive_regulation FAS F2RL3 24795528 1062770 Positive_regulation FAS FADD 10839812 1515696 Positive_regulation FAS FADD 22361748 554950 Positive_regulation FAS FADD 22859258 1086653 Positive_regulation FAS FAH 23275493 992723 Positive_regulation FAS FAH 23275493 992724 Positive_regulation FAS FAS 10601365 1513782 Positive_regulation FAS FAS 10839799 1515554 Positive_regulation FAS FAS 16080799 248876 Positive_regulation FAS FAS 18070911 1346801 Positive_regulation FAS FAS 19118384 1983115 Positive_regulation FAS FAS 19196465 112759 Positive_regulation FAS FAS 22084408 1566074 Positive_regulation FAS FAS 22963678 1231247 Positive_regulation FAS FAS 23285096 2732516 Positive_regulation FAS FAS 23372642 2745533 Positive_regulation FAS FAS 24499503 350224 Positive_regulation FAS FAS 9683298 447469 Positive_regulation FAS FASLG 10408413 414722 Positive_regulation FAS FASLG 10574243 415554 Positive_regulation FAS FASLG 10579724 1253137 Positive_regulation FAS FASLG 10579724 1253160 Positive_regulation FAS FASLG 10579724 1253165 Positive_regulation FAS FASLG 10601365 1513783 Positive_regulation FAS FASLG 10662780 1255837 Positive_regulation FAS FASLG 10864195 417146 Positive_regulation FAS FASLG 11034606 1517723 Positive_regulation FAS FASLG 11097206 702059 Positive_regulation FAS FASLG 11104808 1518132 Positive_regulation FAS FASLG 11157988 1267365 Positive_regulation FAS FASLG 11747320 420378 Positive_regulation FAS FASLG 12045239 1523499 Positive_regulation FAS FASLG 12110144 99303 Positive_regulation FAS FASLG 12932288 99924 Positive_regulation FAS FASLG 14609433 3095296 Positive_regulation FAS FASLG 14612908 423764 Positive_regulation FAS FASLG 14651748 3095616 Positive_regulation FAS FASLG 15038834 382349 Positive_regulation FAS FASLG 15123887 1212189 Positive_regulation FAS FASLG 15795317 1319312 Positive_regulation FAS FASLG 15795317 1319316 Positive_regulation FAS FASLG 15795317 1319317 Positive_regulation FAS FASLG 15795317 1319319 Positive_regulation FAS FASLG 15795317 1319320 Positive_regulation FAS FASLG 15795317 1319326 Positive_regulation FAS FASLG 16080799 248877 Positive_regulation FAS FASLG 16277676 104618 Positive_regulation FAS FASLG 17225862 2374555 Positive_regulation FAS FASLG 17295922 1651098 Positive_regulation FAS FASLG 19055752 1849889 Positive_regulation FAS FASLG 19064696 1553009 Positive_regulation FAS FASLG 19266094 2406961 Positive_regulation FAS FASLG 19794494 1983921 Positive_regulation FAS FASLG 19955213 1771477 Positive_regulation FAS FASLG 20140201 2440059 Positive_regulation FAS FASLG 20359743 2252725 Positive_regulation FAS FASLG 20956499 716764 Positive_regulation FAS FASLG 20979658 1723393 Positive_regulation FAS FASLG 21258649 2244117 Positive_regulation FAS FASLG 21264287 2495207 Positive_regulation FAS FASLG 21760870 2220405 Positive_regulation FAS FASLG 21912551 1144737 Positive_regulation FAS FASLG 22022540 2563751 Positive_regulation FAS FASLG 22084408 1566076 Positive_regulation FAS FASLG 22087287 2571279 Positive_regulation FAS FASLG 22135505 3128235 Positive_regulation FAS FASLG 22279281 1048045 Positive_regulation FAS FASLG 22375159 3177197 Positive_regulation FAS FASLG 22540380 264587 Positive_regulation FAS FASLG 22577260 88183 Positive_regulation FAS FASLG 22577260 88184 Positive_regulation FAS FASLG 22737174 636390 Positive_regulation FAS FASLG 22778762 636615 Positive_regulation FAS FASLG 22778762 636618 Positive_regulation FAS FASLG 22824368 1724867 Positive_regulation FAS FASLG 22859258 1086652 Positive_regulation FAS FASLG 22916262 2680583 Positive_regulation FAS FASLG 23191987 357282 Positive_regulation FAS FASLG 23191987 357290 Positive_regulation FAS FASLG 23358309 1684702 Positive_regulation FAS FASLG 23374533 2113854 Positive_regulation FAS FASLG 23408968 2753078 Positive_regulation FAS FASLG 23412386 559940 Positive_regulation FAS FASLG 23412386 559943 Positive_regulation FAS FASLG 23429285 559990 Positive_regulation FAS FASLG 23578204 1678689 Positive_regulation FAS FASLG 23741982 3215692 Positive_regulation FAS FASLG 23762085 637547 Positive_regulation FAS FASLG 23840967 1154173 Positive_regulation FAS FASLG 23977985 220688 Positive_regulation FAS FASLG 24212818 498630 Positive_regulation FAS FASLG 24658576 2937856 Positive_regulation FAS FASLG 24676213 2946898 Positive_regulation FAS FASLG 25579087 1736375 Positive_regulation FAS FASLG 7595225 1590970 Positive_regulation FAS FASLG 8642300 1596779 Positive_regulation FAS FASLG 8760796 1598729 Positive_regulation FAS FASLG 9547332 1602599 Positive_regulation FAS FASLG 9892626 1605116 Positive_regulation FAS FAT1 23275493 992725 Positive_regulation FAS FFAR4 25076939 880998 Positive_regulation FAS FLOT2 24204853 2874473 Positive_regulation FAS FN1 25314577 3015621 Positive_regulation FAS FOXL2 24240106 1685251 Positive_regulation FAS FOXO3 18312651 462639 Positive_regulation FAS FOXP3 22905732 356041 Positive_regulation FAS FXR1 24872814 1074157 Positive_regulation FAS FXR2 24872814 1074158 Positive_regulation FAS G6PD 25272231 1131550 Positive_regulation FAS GLI3 24044691 294976 Positive_regulation FAS GLMN 22916262 2680585 Positive_regulation FAS GLMN 23840967 1154193 Positive_regulation FAS GNRH1 24622841 3081732 Positive_regulation FAS GNRH1 24622841 3081733 Positive_regulation FAS GNRH1 24622841 3081747 Positive_regulation FAS GNRH1 24622841 3081756 Positive_regulation FAS GNRH1 24622841 3081757 Positive_regulation FAS GNRH1 24622841 3081759 Positive_regulation FAS GRAP2 9362518 1464796 Positive_regulation FAS HLA-DRB1 22681760 264864 Positive_regulation FAS HMGB1 20565784 1626058 Positive_regulation FAS HMGB1 20565784 1626059 Positive_regulation FAS HMGB1 20565784 1626060 Positive_regulation FAS HMGB1 20565784 1626061 Positive_regulation FAS HMGB1 20565784 1626062 Positive_regulation FAS HMGB1 20565784 1626063 Positive_regulation FAS HMGB1 20565784 1626064 Positive_regulation FAS HMGB1 20565784 1626076 Positive_regulation FAS HMGB1 20565784 1626077 Positive_regulation FAS HMGB1 20565784 1626087 Positive_regulation FAS HMGB1 20565784 1626088 Positive_regulation FAS HMGB1 20565784 1626089 Positive_regulation FAS HMGB1 20565784 1626096 Positive_regulation FAS HOXB4 22915992 1714338 Positive_regulation FAS HRAS 11710833 420157 Positive_regulation FAS HS3ST2 22916262 2680586 Positive_regulation FAS IAPP 23607096 181444 Positive_regulation FAS IFN1@ 22084408 1566077 Positive_regulation FAS IFNG 15899041 103696 Positive_regulation FAS IFNG 17162364 630559 Positive_regulation FAS IFNG 18474096 110749 Positive_regulation FAS IKBKB 21850048 552439 Positive_regulation FAS IKBKB 21850048 552440 Positive_regulation FAS IL10 15512788 831015 Positive_regulation FAS IL10 17162368 630584 Positive_regulation FAS IL11 15512788 831016 Positive_regulation FAS IL12A 22448123 3128313 Positive_regulation FAS IL12A 23762085 637548 Positive_regulation FAS IL12A 24514955 488379 Positive_regulation FAS IL12B 19390568 487391 Positive_regulation FAS IL12B 22448123 3128314 Positive_regulation FAS IL12B 23762085 637549 Positive_regulation FAS IL12B 24514955 488380 Positive_regulation FAS IL13 15512788 831017 Positive_regulation FAS IL15 15512788 831018 Positive_regulation FAS IL16 15512788 831019 Positive_regulation FAS IL18 15512788 831020 Positive_regulation FAS IL18 23577265 1154668 Positive_regulation FAS IL18 23762085 637550 Positive_regulation FAS IL18 24115947 909160 Positive_regulation FAS IL19 15512788 831021 Positive_regulation FAS IL1A 10704145 1737014 Positive_regulation FAS IL1A 10704145 1737015 Positive_regulation FAS IL1A 15292926 424857 Positive_regulation FAS IL1A 15762980 1162698 Positive_regulation FAS IL1A 20565784 1626078 Positive_regulation FAS IL1A 21251296 1697021 Positive_regulation FAS IL1A 21869830 547463 Positive_regulation FAS IL1A 21869830 547477 Positive_regulation FAS IL1A 24663217 2938015 Positive_regulation FAS IL1A 9334358 1601702 Positive_regulation FAS IL1A 9334358 1601703 Positive_regulation FAS IL1B 10704145 1737016 Positive_regulation FAS IL1B 10704145 1737017 Positive_regulation FAS IL1B 21120077 1046260 Positive_regulation FAS IL2 15512788 831022 Positive_regulation FAS IL2 19487421 1555049 Positive_regulation FAS IL2 7504062 1588761 Positive_regulation FAS IL2 8642275 1596521 Positive_regulation FAS IL20 15512788 831023 Positive_regulation FAS IL21 15512788 831024 Positive_regulation FAS IL22 15512788 831007 Positive_regulation FAS IL23A 19390568 487390 Positive_regulation FAS IL24 15512788 831005 Positive_regulation FAS IL25 15512788 831006 Positive_regulation FAS IL26 15512788 831011 Positive_regulation FAS IL27 15512788 831012 Positive_regulation FAS IL3 15512788 831025 Positive_regulation FAS IL31 15512788 831013 Positive_regulation FAS IL32 15512788 831010 Positive_regulation FAS IL33 15512788 831009 Positive_regulation FAS IL34 15512788 831014 Positive_regulation FAS IL37 15512788 831008 Positive_regulation FAS IL4 15512788 831026 Positive_regulation FAS IL4 9064343 1600359 Positive_regulation FAS IL5 15512788 831027 Positive_regulation FAS IL6 15512788 831028 Positive_regulation FAS IL7 15512788 831029 Positive_regulation FAS IL7 22194871 2582993 Positive_regulation FAS IL7 22194871 2583058 Positive_regulation FAS IL7 22194871 2583059 Positive_regulation FAS IL7 22194871 2583060 Positive_regulation FAS IL7 22194871 2583061 Positive_regulation FAS IL7 22194871 2583064 Positive_regulation FAS IL7 22194871 2583065 Positive_regulation FAS IL7 22194871 2583066 Positive_regulation FAS IL7 22194871 2583071 Positive_regulation FAS IL7 22194871 2583072 Positive_regulation FAS IL7 22194871 2583073 Positive_regulation FAS IL7 22194871 2583074 Positive_regulation FAS IL7 22194871 2583077 Positive_regulation FAS IL7 22194871 2583078 Positive_regulation FAS IL7 22194871 2583104 Positive_regulation FAS IL7 22194871 2583105 Positive_regulation FAS IL7 22382400 805184 Positive_regulation FAS IL7 24603698 3066367 Positive_regulation FAS IL7R 21679413 1697483 Positive_regulation FAS IL8 15512788 831030 Positive_regulation FAS IL8 21120077 1046261 Positive_regulation FAS IL9 15512788 831031 Positive_regulation FAS INS 21471514 719050 Positive_regulation FAS INS 22022575 2563902 Positive_regulation FAS INS 22966071 724677 Positive_regulation FAS INS 23405244 2752480 Positive_regulation FAS INS 23474483 726811 Positive_regulation FAS INS 23691094 2794392 Positive_regulation FAS INS 24026559 730228 Positive_regulation FAS INS 24458133 840358 Positive_regulation FAS INS 24949486 1496455 Positive_regulation FAS INS 24970128 207268 Positive_regulation FAS INSIG1 21843373 1229505 Positive_regulation FAS IRF4 12566414 1525834 Positive_regulation FAS ITIH4 25196285 3224083 Positive_regulation FAS JUN 19806201 2427729 Positive_regulation FAS JUN 24058807 1706252 Positive_regulation FAS KCNK2 24586773 2926358 Positive_regulation FAS KLK3 23880932 1729983 Positive_regulation FAS KRAS 10662780 1255844 Positive_regulation FAS KRAS 11710833 420158 Positive_regulation FAS KRR1 21423395 955219 Positive_regulation FAS KRR1 24336086 570500 Positive_regulation FAS LBP 25013763 194510 Positive_regulation FAS LPA 24744506 1758224 Positive_regulation FAS LPAR6 25285406 2160617 Positive_regulation FAS LY75 24677194 1029693 Positive_regulation FAS LY86 24677194 1029690 Positive_regulation FAS LY9 24677194 1029694 Positive_regulation FAS LY96 24677194 1029691 Positive_regulation FAS LYN 9064343 1600347 Positive_regulation FAS MAP3K12 19270737 2407348 Positive_regulation FAS MAP3K12 19270737 2407352 Positive_regulation FAS MAP3K5 15123887 1212207 Positive_regulation FAS MAP3K5 25594018 2173732 Positive_regulation FAS MAPK1 20573240 1856437 Positive_regulation FAS MAPK1 9396757 1465243 Positive_regulation FAS MAPK10 20573240 1856438 Positive_regulation FAS MAPK11 20573240 1856439 Positive_regulation FAS MAPK12 20573240 1856440 Positive_regulation FAS MAPK13 20573240 1856441 Positive_regulation FAS MAPK14 20573240 1856442 Positive_regulation FAS MAPK15 20573240 1856436 Positive_regulation FAS MAPK3 20573240 1856443 Positive_regulation FAS MAPK3 24324514 824421 Positive_regulation FAS MAPK3 9396757 1465244 Positive_regulation FAS MAPK4 20573240 1856444 Positive_regulation FAS MAPK6 20573240 1856445 Positive_regulation FAS MAPK7 20573240 1856446 Positive_regulation FAS MAPK8 20573240 1856447 Positive_regulation FAS MAPK9 20573240 1856448 Positive_regulation FAS MAPRE3 23712260 1405203 Positive_regulation FAS MED1 22194871 2583107 Positive_regulation FAS MED10 22194871 2583100 Positive_regulation FAS MED11 22194871 2583103 Positive_regulation FAS MED13 22194871 2583087 Positive_regulation FAS MED13L 22194871 2583088 Positive_regulation FAS MED14 22194871 2583092 Positive_regulation FAS MED15 22194871 2583081 Positive_regulation FAS MED16 22194871 2583083 Positive_regulation FAS MED17 22194871 2583094 Positive_regulation FAS MED18 22194871 2583099 Positive_regulation FAS MED19 22194871 2583102 Positive_regulation FAS MED20 22194871 2583082 Positive_regulation FAS MED21 22194871 2583079 Positive_regulation FAS MED22 22194871 2583080 Positive_regulation FAS MED23 22194871 2583093 Positive_regulation FAS MED24 22194871 2583089 Positive_regulation FAS MED25 22194871 2583101 Positive_regulation FAS MED26 22194871 2583095 Positive_regulation FAS MED27 22194871 2583096 Positive_regulation FAS MED29 22194871 2583091 Positive_regulation FAS MED30 22194871 2583090 Positive_regulation FAS MED31 22194871 2583098 Positive_regulation FAS MED4 22194871 2583084 Positive_regulation FAS MED6 22194871 2583085 Positive_regulation FAS MED7 22194871 2583097 Positive_regulation FAS MED8 22194871 2583086 Positive_regulation FAS MICE 25013763 194502 Positive_regulation FAS MLST8 23676995 589633 Positive_regulation FAS MLXIPL 22111040 730340 Positive_regulation FAS MMP9 16316466 383091 Positive_regulation FAS MS4A1 20815894 1504476 Positive_regulation FAS MSH2 11641530 1632787 Positive_regulation FAS MSH3 11641530 1632788 Positive_regulation FAS MSH4 11641530 1632789 Positive_regulation FAS MSH5 11641530 1632790 Positive_regulation FAS MSH6 11641530 1632791 Positive_regulation FAS MT-CO2 22509351 2618753 Positive_regulation FAS MTOR 23676995 589636 Positive_regulation FAS MTOR PMC4233553 477207 Positive_regulation FAS MYL2 23551528 1480247 Positive_regulation FAS MYL2 23551528 1480248 Positive_regulation FAS MYLIP 23166734 2718790 Positive_regulation FAS MYLIP 23242178 477796 Positive_regulation FAS MYLIP 23922812 2826717 Positive_regulation FAS MYLIP 23950995 2833151 Positive_regulation FAS MYLIP 25552935 1063941 Positive_regulation FAS MYLIP 25552935 1063946 Positive_regulation FAS MYLK 20037648 2435343 Positive_regulation FAS NAALADL1 20399848 452516 Positive_regulation FAS NDRG2 22920753 266197 Positive_regulation FAS NFATC2IP 23170112 842635 Positive_regulation FAS NFYA 21614092 552107 Positive_regulation FAS NFYB 21614092 552108 Positive_regulation FAS NFYC 21614092 552109 Positive_regulation FAS NGF 24600432 935537 Positive_regulation FAS NOS1 22824368 1724872 Positive_regulation FAS NOS2 22110764 2573324 Positive_regulation FAS NOS2 22824368 1724873 Positive_regulation FAS NOS3 22824368 1724874 Positive_regulation FAS NOTCH1 16542414 298691 Positive_regulation FAS NOTCH2 16542414 298692 Positive_regulation FAS NOTCH3 16542414 298693 Positive_regulation FAS NOTCH4 16542414 298694 Positive_regulation FAS NRAS 11710833 420159 Positive_regulation FAS NSRP1 21296756 2060631 Positive_regulation FAS NUB1 25337562 1241415 Positive_regulation FAS OPA1 22194871 2583106 Positive_regulation FAS ORAI1 22654884 901503 Positive_regulation FAS OSBP 24970128 207269 Positive_regulation FAS OSR1 24931004 1681288 Positive_regulation FAS P2RX7 23618909 561680 Positive_regulation FAS PAK4 20719960 1781992 Positive_regulation FAS PARVA 19667130 1367785 Positive_regulation FAS PFN1 17940506 429593 Positive_regulation FAS PFN1 17940506 429594 Positive_regulation FAS PIK3CA 19798413 2427437 Positive_regulation FAS PIK3CA 19798413 2427438 Positive_regulation FAS PIK3CA 19798413 2427585 Positive_regulation FAS PIK3CA 19798413 2427589 Positive_regulation FAS PIK3CA PMC4233553 477208 Positive_regulation FAS PIK3R1 19798413 2427439 Positive_regulation FAS PIK3R1 19798413 2427440 Positive_regulation FAS PIK3R1 19798413 2427586 Positive_regulation FAS PIK3R1 19798413 2427590 Positive_regulation FAS PIK3R1 PMC4233553 477209 Positive_regulation FAS PLA2G1B 25538730 897142 Positive_regulation FAS PLEC 20702585 1779846 Positive_regulation FAS PML 23526763 942755 Positive_regulation FAS POLDIP2 24324514 824420 Positive_regulation FAS PPARA 22977681 2115205 Positive_regulation FAS PPARA 23193424 816277 Positive_regulation FAS PRDX2 23640463 561722 Positive_regulation FAS PRDX2 23640463 561724 Positive_regulation FAS PRKAA1 24490657 295689 Positive_regulation FAS PRKAA1 25049694 136339 Positive_regulation FAS PRKAA2 24490657 295690 Positive_regulation FAS PRKAA2 25049694 136340 Positive_regulation FAS PRKAB1 24490657 295691 Positive_regulation FAS PRKAB1 25049694 136341 Positive_regulation FAS PRKAB2 24490657 295692 Positive_regulation FAS PRKAB2 25049694 136342 Positive_regulation FAS PRKACB PMC4118455 809613 Positive_regulation FAS PRKACG PMC4118455 809614 Positive_regulation FAS PRKAG1 24490657 295693 Positive_regulation FAS PRKAG1 25049694 136343 Positive_regulation FAS PRKAG2 24490657 295694 Positive_regulation FAS PRKAG2 25049694 136344 Positive_regulation FAS PRKAR1A PMC4118455 809615 Positive_regulation FAS PRKAR1B PMC4118455 809616 Positive_regulation FAS PRKAR2A PMC4118455 809617 Positive_regulation FAS PRKAR2B PMC4118455 809618 Positive_regulation FAS PSIP1 22046349 2566522 Positive_regulation FAS PSIP1 22046349 2566767 Positive_regulation FAS PTBP1 24957602 2102140 Positive_regulation FAS PTEN 22949843 1098052 Positive_regulation FAS PTEN 22949843 1098060 Positive_regulation FAS PTEN 25003395 504992 Positive_regulation FAS PTK2 24683541 187630 Positive_regulation FAS PTK6 24683541 187631 Positive_regulation FAS PTK7 24683541 187632 Positive_regulation FAS PTPN11 21118992 1783687 Positive_regulation FAS PTPN12 22194823 2582766 Positive_regulation FAS PUM1 24901238 3068129 Positive_regulation FAS PXN 20030821 507966 Positive_regulation FAS RAC1 11259103 418413 Positive_regulation FAS RAC1 16492808 1327967 Positive_regulation FAS RAC1 22880146 143909 Positive_regulation FAS RAC1 24632816 2934273 Positive_regulation FAS RAF1 11157988 1267358 Positive_regulation FAS RAF1 16365167 1326357 Positive_regulation FAS RAF1 16365167 1326370 Positive_regulation FAS RAF1 16365167 1326373 Positive_regulation FAS RASA1 10769036 1257224 Positive_regulation FAS RASA1 10769036 1257244 Positive_regulation FAS RB1 24800165 2163161 Positive_regulation FAS RELA 10075983 1511257 Positive_regulation FAS RELA 23264905 2162151 Positive_regulation FAS RHO 19075110 1362413 Positive_regulation FAS RHO 22514537 957094 Positive_regulation FAS RHOA 19075110 1362414 Positive_regulation FAS RHOA 22500172 1067452 Positive_regulation FAS RHOC 23825001 2809331 Positive_regulation FAS RIPK2 24658576 2937875 Positive_regulation FAS RIPK3 21423395 955218 Positive_regulation FAS RIPK3 24336086 570499 Positive_regulation FAS RNF19A 9362518 1464832 Positive_regulation FAS ROCK1 18955552 1359440 Positive_regulation FAS ROCK1 18955552 1359444 Positive_regulation FAS ROCK1 20037648 2435341 Positive_regulation FAS ROCK1 22505938 1067903 Positive_regulation FAS ROCK1 22830013 1689006 Positive_regulation FAS ROCK2 18955552 1359441 Positive_regulation FAS ROCK2 18955552 1359445 Positive_regulation FAS ROCK2 20037648 2435342 Positive_regulation FAS ROCK2 22505938 1067904 Positive_regulation FAS ROCK2 22830013 1689007 Positive_regulation FAS RPTOR 23676995 589635 Positive_regulation FAS RRM1 24957602 2102138 Positive_regulation FAS RRM2 24957602 2102139 Positive_regulation FAS SCD 22413010 2610086 Positive_regulation FAS SETD8 22117221 770919 Positive_regulation FAS SHH 22046349 2566518 Positive_regulation FAS SIM2 24040277 2846360 Positive_regulation FAS SLC25A16 22087285 2571243 Positive_regulation FAS SLC25A16 22087285 2571265 Positive_regulation FAS SNTG1 23453597 700522 Positive_regulation FAS SP1 19936232 2431799 Positive_regulation FAS SP3 19936232 2431800 Positive_regulation FAS SRC 22291036 1394921 Positive_regulation FAS SRC 23453597 700509 Positive_regulation FAS SREBF1 18838394 2036725 Positive_regulation FAS SREBF1 20041157 2435607 Positive_regulation FAS SREBF1 20173757 9475 Positive_regulation FAS SREBF1 20173757 9478 Positive_regulation FAS SREBF1 20173757 9482 Positive_regulation FAS SREBF1 20205889 2112622 Positive_regulation FAS SREBF1 22111040 730339 Positive_regulation FAS SREBF1 22370853 1140328 Positive_regulation FAS SREBF1 22570770 1669926 Positive_regulation FAS SREBF1 22844333 814861 Positive_regulation FAS SREBF1 22977681 2115204 Positive_regulation FAS SREBF1 23304111 3076102 Positive_regulation FAS SREBF1 23431342 817289 Positive_regulation FAS SREBF1 23737763 980660 Positive_regulation FAS SREBF1 23874950 2823745 Positive_regulation FAS SREBF1 24067358 3137275 Positive_regulation FAS SREBF1 24454838 2910135 Positive_regulation FAS SREBF1 24520358 2921495 Positive_regulation FAS SREBF1 24625548 2933796 Positive_regulation FAS SREBF1 24625548 2933799 Positive_regulation FAS SREBF1 24678767 1726822 Positive_regulation FAS SREBF1 24843688 1494551 Positive_regulation FAS SREBF1 25250914 1131016 Positive_regulation FAS STAT1 15296508 523866 Positive_regulation FAS STAT1 22221539 1651300 Positive_regulation FAS STAT3 24058807 1706251 Positive_regulation FAS STAT3 24743777 504244 Positive_regulation FAS STIM1 22654884 901502 Positive_regulation FAS STIP1 23977369 2840072 Positive_regulation FAS SULT2A1 25250309 873196 Positive_regulation FAS TAT 25196285 3224103 Positive_regulation FAS TBCE 23091461 959471 Positive_regulation FAS TCF12 14979919 458296 Positive_regulation FAS TCF15 14979919 458297 Positive_regulation FAS TCF19 14979919 458298 Positive_regulation FAS TCF20 14979919 458299 Positive_regulation FAS TCF21 14979919 458300 Positive_regulation FAS TCF23 14979919 458304 Positive_regulation FAS TCF24 14979919 458306 Positive_regulation FAS TCF25 14979919 458305 Positive_regulation FAS TCF3 14979919 458301 Positive_regulation FAS TCF4 14979919 458302 Positive_regulation FAS TCF7 14979919 458303 Positive_regulation FAS TIA1 24682828 2099672 Positive_regulation FAS TIA1 7544399 1590535 Positive_regulation FAS TIMP3 19090960 112203 Positive_regulation FAS TLN1 19667130 1367784 Positive_regulation FAS TLN1 23375895 666727 Positive_regulation FAS TLN1 23468527 1812675 Positive_regulation FAS TLN2 23375895 666729 Positive_regulation FAS TLR4 20964825 855119 Positive_regulation FAS TLR4 23349502 725973 Positive_regulation FAS TLR4 23805400 20271 Positive_regulation FAS TLR4 24101950 2227228 Positive_regulation FAS TNF 10075983 1511260 Positive_regulation FAS TNF 10209037 1511462 Positive_regulation FAS TNF 10684857 1514495 Positive_regulation FAS TNF 10864195 417145 Positive_regulation FAS TNF 11581316 1521083 Positive_regulation FAS TNF 11581316 1521084 Positive_regulation FAS TNF 11581316 1521097 Positive_regulation FAS TNF 11581316 1521100 Positive_regulation FAS TNF 11581316 1521102 Positive_regulation FAS TNF 11581316 1521104 Positive_regulation FAS TNF 12932288 99906 Positive_regulation FAS TNF 12932288 99907 Positive_regulation FAS TNF 16941746 3230868 Positive_regulation FAS TNF 17254331 165995 Positive_regulation FAS TNF 17254331 166001 Positive_regulation FAS TNF 17764548 108946 Positive_regulation FAS TNF 18226185 109994 Positive_regulation FAS TNF 18474096 110748 Positive_regulation FAS TNF 20185810 712897 Positive_regulation FAS TNF 20358022 35579 Positive_regulation FAS TNF 21850048 552435 Positive_regulation FAS TNF 21850048 552436 Positive_regulation FAS TNF 21850048 552455 Positive_regulation FAS TNF 21949656 3053589 Positive_regulation FAS TNF 22707768 1044062 Positive_regulation FAS TNF 22824096 856057 Positive_regulation FAS TNF 22929310 1506547 Positive_regulation FAS TNF 22929310 1506548 Positive_regulation FAS TNF 23191987 357288 Positive_regulation FAS TNF 23372642 2745532 Positive_regulation FAS TNF 23741982 3215690 Positive_regulation FAS TNF 23762085 637546 Positive_regulation FAS TNF 23762085 637569 Positive_regulation FAS TNF 23762085 637574 Positive_regulation FAS TNF 24465826 2911826 Positive_regulation FAS TNF 24574904 3156044 Positive_regulation FAS TNF 24574904 3156049 Positive_regulation FAS TNF 9449720 1602533 Positive_regulation FAS TNF 9467064 797623 Positive_regulation FAS TNF PMC4053802 2247156 Positive_regulation FAS TNFRSF10B 22084408 1566073 Positive_regulation FAS TNFRSF1A 17254331 166008 Positive_regulation FAS TNFRSF1A 21850048 552437 Positive_regulation FAS TNFRSF1A 21850048 552438 Positive_regulation FAS TNFRSF1A 21850048 552446 Positive_regulation FAS TNFRSF1A 21850048 552452 Positive_regulation FAS TNFRSF1B 17254331 165994 Positive_regulation FAS TNFRSF1B 17254331 165996 Positive_regulation FAS TNFRSF1B 17254331 166002 Positive_regulation FAS TNFRSF1B 17254331 166004 Positive_regulation FAS TNFRSF1B 17254331 166005 Positive_regulation FAS TNFRSF1B 17254331 166009 Positive_regulation FAS TNFSF10 22084408 1566075 Positive_regulation FAS TNFSF10 22087287 2571278 Positive_regulation FAS TNFSF10 22194871 2583057 Positive_regulation FAS TNFSF10 23191987 357289 Positive_regulation FAS TNFSF10 23741982 3215691 Positive_regulation FAS TNFSF10 25197653 198811 Positive_regulation FAS TNFSF11 23300516 2733557 Positive_regulation FAS TNFSF13 22545112 2623409 Positive_regulation FAS TNFSF13B 11015437 1517310 Positive_regulation FAS TNMD 23825001 2809330 Positive_regulation FAS TOP1 22066019 2568839 Positive_regulation FAS TP53 11747320 420379 Positive_regulation FAS TP53 11870542 420574 Positive_regulation FAS TP53 12923319 1634228 Positive_regulation FAS TP53 14609433 3095305 Positive_regulation FAS TP53 15038834 382343 Positive_regulation FAS TP53 15038834 382344 Positive_regulation FAS TP53 15038834 382347 Positive_regulation FAS TP53 15559377 630342 Positive_regulation FAS TP53 16709241 1845262 Positive_regulation FAS TP53 20957096 1090323 Positive_regulation FAS TP53 21364648 549816 Positive_regulation FAS TP53 21509038 551804 Positive_regulation FAS TP53 21509038 551809 Positive_regulation FAS TP53 21614092 552104 Positive_regulation FAS TP53 21614092 552106 Positive_regulation FAS TP53 21824395 3112498 Positive_regulation FAS TP53 22474491 814053 Positive_regulation FAS TP53 22474491 814054 Positive_regulation FAS TP53 22951985 557649 Positive_regulation FAS TP53 23060884 904636 Positive_regulation FAS TP53 23166734 2718849 Positive_regulation FAS TP53 23404198 93263 Positive_regulation FAS TP53 23894460 2824805 Positive_regulation FAS TP53 24622841 3081730 Positive_regulation FAS TP53 24622841 3081731 Positive_regulation FAS TP53 24622841 3081746 Positive_regulation FAS TP53 25337543 1241225 Positive_regulation FAS TP53 9472635 446880 Positive_regulation FAS TP53 9841917 1604736 Positive_regulation FAS TP53 9841917 1604737 Positive_regulation FAS TP53 9841917 1604738 Positive_regulation FAS TP53 9841917 1604741 Positive_regulation FAS TP53 9841917 1604742 Positive_regulation FAS TP53 9841917 1604743 Positive_regulation FAS TP53 9841917 1604744 Positive_regulation FAS TP53 9841917 1604745 Positive_regulation FAS TP53 9841917 1604747 Positive_regulation FAS TP53 9841917 1604749 Positive_regulation FAS TP53 9841917 1604752 Positive_regulation FAS TRAF3 9221764 1601324 Positive_regulation FAS TRIM26 16080799 248882 Positive_regulation FAS TRIP6 16880273 1331776 Positive_regulation FAS TXN 23264905 2162150 Positive_regulation FAS UGCG 22022575 2563901 Positive_regulation FAS UGCG 22022575 2563903 Positive_regulation FAS USF1 18838394 2036726 Positive_regulation FAS USP2 18755030 324117 Positive_regulation FAS USP2 18755030 324122 Positive_regulation FAS VCL 18056416 1346753 Positive_regulation FAS VCL 18056416 1346758 Positive_regulation FAS VCL 23375895 666726 Positive_regulation FAS VCL 23375895 666728 Positive_regulation FAS VCL 23375895 666769 Positive_regulation FAS VCL 23468527 1812676 Positive_regulation FAS VCL 25033086 2990211 Positive_regulation FAS VEGFB 24448490 784297 Positive_regulation FAS WNK1 19644561 1212945 Positive_regulation FAS YME1L1 25104883 1760310 Positive_regulation FAS ZMAT3 24469038 2154627 Positive_regulation FAS ZMAT3 24469038 2154628 Positive_regulation FAS ZMAT3 24469038 2154635 Positive_regulation FAS ZMAT3 24469038 2154640 Positive_regulation FASLG ANGPT1 23554782 1226177 Positive_regulation FASLG ANGPT1 23554782 1226210 Positive_regulation FASLG EPHB2 23598406 561395 Positive_regulation FASLG EPHB2 24337492 2171527 Positive_regulation FASLG FAS 10330437 1511763 Positive_regulation FASLG FAS 10579724 1253138 Positive_regulation FASLG FAS 10579724 1253161 Positive_regulation FASLG FAS 10839301 417144 Positive_regulation FASLG FAS 11747320 420380 Positive_regulation FASLG FAS 12610520 422249 Positive_regulation FASLG FAS 15038834 382350 Positive_regulation FASLG FAS 15123887 1212190 Positive_regulation FASLG FAS 15148335 1532702 Positive_regulation FASLG FAS 16080799 248878 Positive_regulation FASLG FAS 16186185 1537911 Positive_regulation FASLG FAS 17225862 2374557 Positive_regulation FASLG FAS 17295922 1651099 Positive_regulation FASLG FAS 19055752 1849890 Positive_regulation FASLG FAS 19064696 1553010 Positive_regulation FASLG FAS 19955213 1771478 Positive_regulation FASLG FAS 20140201 2440060 Positive_regulation FASLG FAS 21258649 2244118 Positive_regulation FASLG FAS 22084408 1566083 Positive_regulation FASLG FAS 22737174 636391 Positive_regulation FASLG FAS 22778762 636616 Positive_regulation FASLG FAS 22824368 1724868 Positive_regulation FASLG FAS 22829769 3058764 Positive_regulation FASLG FAS 23009687 412226 Positive_regulation FASLG FAS 23191987 357283 Positive_regulation FASLG FAS 23191987 357293 Positive_regulation FASLG FAS 23285096 2732517 Positive_regulation FASLG FAS 23358309 1684703 Positive_regulation FASLG FAS 23374533 2113855 Positive_regulation FASLG FAS 23408968 2753079 Positive_regulation FASLG FAS 23412386 559941 Positive_regulation FASLG FAS 23412386 559944 Positive_regulation FASLG FAS 23762085 637552 Positive_regulation FASLG FAS 23762085 637578 Positive_regulation FASLG FAS 24122010 18561 Positive_regulation FASLG FAS 24212818 498632 Positive_regulation FASLG FAS 24658576 2937857 Positive_regulation FASLG FAS 25177675 1051039 Positive_regulation FASLG FAS 7544399 1590536 Positive_regulation FASLG FAS 8760796 1598730 Positive_regulation FASLG FAS 9547332 1602600 Positive_regulation FASLG FAS 9892626 1605118 Positive_regulation FASLG FOXO1 16336649 656497 Positive_regulation FASLG FOXO1 25093037 1650945 Positive_regulation FASLG GRIK2 23949220 564815 Positive_regulation FASLG GRIK2 23949220 564818 Positive_regulation FASLG MAP2K6 20868529 1647830 Positive_regulation FASLG MMP28 16457714 1242322 Positive_regulation FASLG MMP28 23698793 3136026 Positive_regulation FASLG MMP7 16457714 1242337 Positive_regulation FASLG MMP7 16571143 3107188 Positive_regulation FASLG MMP7 16571143 3107190 Positive_regulation FASLG MMP7 23698793 3136018 Positive_regulation FASLG MMP7 23698793 3136019 Positive_regulation FASLG MMP7 23698793 3136041 Positive_regulation FASLG MMP7 23698793 3136070 Positive_regulation FASLG MMP7 23698793 3136072 Positive_regulation FASLG MMP7 24741325 487734 Positive_regulation FASLG TNF 10209037 1511463 Positive_regulation FASLG TNF 14613529 3095434 Positive_regulation FASLG TNF 16941746 3230869 Positive_regulation FASLG TNF 20529219 34671 Positive_regulation FASLG TNF 21298033 2499371 Positive_regulation FASLG TNF 21298033 2499376 Positive_regulation FASLG TNF 21850212 1239535 Positive_regulation FASLG TNF 22653829 1680800 Positive_regulation FASLG TNF 23762085 637551 Positive_regulation FASLG TNF 23762085 637577 Positive_regulation FASLG TNF 24465826 2911827 Positive_regulation FASLG TNF 24574904 3156045 Positive_regulation FASLG TNF 24574904 3156050 Positive_regulation FASLG TNF 24667392 2938709 Positive_regulation FASLG TNF 9126933 1601100 Positive_regulation FASLG TNFSF10 22084408 1566084 Positive_regulation FASLG TNFSF10 22087287 2571281 Positive_regulation FASLG TNFSF10 24367142 3079932 Positive_regulation FASLG TNFSF10 24610963 3712 Positive_regulation FASN FOXO1 23056614 2702418 Positive_regulation FASN FOXO1 23532271 453336 Positive_regulation FASN MAP2K6 19935796 434039 Positive_regulation FASN TNFSF10 23348588 559164 Positive_regulation FAT1 TNFSF10 24442637 773623 Positive_regulation FAT3 DCHS2 25340762 2366728 Positive_regulation FBN1 CTGF 21655297 2527849 Positive_regulation FBN1 CTGF 24558600 1154264 Positive_regulation FBXO31 CCND1 19412162 1983378 Positive_regulation FBXO31 CCND1 19412162 1983384 Positive_regulation FBXO32 ACVR2B 20856813 2474795 Positive_regulation FBXO32 AHSA1 23071610 2703218 Positive_regulation FBXO32 AHSA1 23071610 2703219 Positive_regulation FBXO32 AHSA1 25566431 1498389 Positive_regulation FBXO32 AKT1 20856813 2474796 Positive_regulation FBXO32 AKT1 22476916 1238802 Positive_regulation FBXO32 AKT1 22690213 1073156 Positive_regulation FBXO32 AKT1 23499576 3204100 Positive_regulation FBXO32 AKT1 24382946 3155672 Positive_regulation FBXO32 AKT1 PMC3332414 134761 Positive_regulation FBXO32 AKT2 20856813 2474797 Positive_regulation FBXO32 AKT2 22476916 1238803 Positive_regulation FBXO32 AKT2 22690213 1073157 Positive_regulation FBXO32 AKT2 23499576 3204101 Positive_regulation FBXO32 AKT2 24382946 3155673 Positive_regulation FBXO32 AKT3 20856813 2474798 Positive_regulation FBXO32 AKT3 22476916 1238804 Positive_regulation FBXO32 AKT3 22690213 1073158 Positive_regulation FBXO32 AKT3 23499576 3204102 Positive_regulation FBXO32 AKT3 24382946 3155674 Positive_regulation FBXO32 CBL 23762056 1073568 Positive_regulation FBXO32 CRK 22477519 1238895 Positive_regulation FBXO32 CRK 22701436 958014 Positive_regulation FBXO32 CRK 23046544 3161175 Positive_regulation FBXO32 DUX4 22053214 2568071 Positive_regulation FBXO32 DUX4 22053214 2568082 Positive_regulation FBXO32 EEF1A2 21267417 742447 Positive_regulation FBXO32 EPHB2 25436606 3030588 Positive_regulation FBXO32 FOXO1 20379369 1214264 Positive_regulation FBXO32 FOXO1 21460183 1789193 Positive_regulation FBXO32 FOXO1 21483870 2512532 Positive_regulation FBXO32 FOXO1 21798082 3160120 Positive_regulation FBXO32 FOXO1 22476916 1238800 Positive_regulation FBXO32 FOXO1 23555761 2775253 Positive_regulation FBXO32 FOXO1 24107265 1870062 Positive_regulation FBXO32 FOXO1 24454908 2910306 Positive_regulation FBXO32 FOXO1 24551104 2923043 Positive_regulation FBXO32 FOXO1 24971321 193328 Positive_regulation FBXO32 FOXO1 24982916 193596 Positive_regulation FBXO32 FOXO1 25032690 2990177 Positive_regulation FBXO32 FOXO1 25276226 1651028 Positive_regulation FBXO32 FOXO1 25294954 1762716 Positive_regulation FBXO32 FOXO3 20379369 1214265 Positive_regulation FBXO32 FOXO3 20921137 1380126 Positive_regulation FBXO32 FOXO3 21460183 1789194 Positive_regulation FBXO32 FOXO3 21483870 2512552 Positive_regulation FBXO32 FOXO3 21798082 3160121 Positive_regulation FBXO32 FOXO3 21876808 1155334 Positive_regulation FBXO32 FOXO3 22476916 1238801 Positive_regulation FBXO32 FOXO3 22586590 722913 Positive_regulation FBXO32 FOXO3 23011132 1934372 Positive_regulation FBXO32 FOXO3 23268536 740142 Positive_regulation FBXO32 FOXO3 23374633 245344 Positive_regulation FBXO32 FOXO3 23762056 1073580 Positive_regulation FBXO32 FOXO3 23922868 2826917 Positive_regulation FBXO32 FOXO3 24107265 1870063 Positive_regulation FBXO32 FOXO3 24971321 193329 Positive_regulation FBXO32 FOXO3 24982916 193597 Positive_regulation FBXO32 FOXO3 25032690 2990178 Positive_regulation FBXO32 FOXO3 25163459 1239300 Positive_regulation FBXO32 FOXO4 20379369 1214266 Positive_regulation FBXO32 FOXO4 21460183 1789195 Positive_regulation FBXO32 FOXO4 21798082 3160122 Positive_regulation FBXO32 FOXO4 22476916 1238805 Positive_regulation FBXO32 FOXO4 24107265 1870064 Positive_regulation FBXO32 FOXO4 24971321 193330 Positive_regulation FBXO32 FOXO6 20379369 1214263 Positive_regulation FBXO32 FOXO6 21460183 1789192 Positive_regulation FBXO32 FOXO6 21798082 3160119 Positive_regulation FBXO32 FOXO6 22476916 1238799 Positive_regulation FBXO32 FOXO6 24107265 1870061 Positive_regulation FBXO32 FOXO6 24971321 193327 Positive_regulation FBXO32 GRAP2 23046544 3161182 Positive_regulation FBXO32 HGF 24963862 2983469 Positive_regulation FBXO32 HGF 24963862 2983470 Positive_regulation FBXO32 HSPB1 24629011 1650610 Positive_regulation FBXO32 IGF1 22974011 2113489 Positive_regulation FBXO32 IGF1 23762056 1073569 Positive_regulation FBXO32 IGF1 PMC3332414 134762 Positive_regulation FBXO32 IL1A 22084407 1566026 Positive_regulation FBXO32 IL1A 24180744 345801 Positive_regulation FBXO32 IL6 22082477 682538 Positive_regulation FBXO32 MAPK1 21187332 1384645 Positive_regulation FBXO32 MAPK1 22082477 682608 Positive_regulation FBXO32 MAPK1 22701436 958016 Positive_regulation FBXO32 MAPK1 23046544 3161190 Positive_regulation FBXO32 MAPK1 23046544 3161220 Positive_regulation FBXO32 MAPK10 21187332 1384646 Positive_regulation FBXO32 MAPK10 22082477 682609 Positive_regulation FBXO32 MAPK10 22701436 958017 Positive_regulation FBXO32 MAPK10 23046544 3161191 Positive_regulation FBXO32 MAPK10 23046544 3161221 Positive_regulation FBXO32 MAPK11 21187332 1384647 Positive_regulation FBXO32 MAPK11 22082477 682610 Positive_regulation FBXO32 MAPK11 22701436 958018 Positive_regulation FBXO32 MAPK11 23046544 3161192 Positive_regulation FBXO32 MAPK11 23046544 3161222 Positive_regulation FBXO32 MAPK12 21187332 1384648 Positive_regulation FBXO32 MAPK12 22082477 682611 Positive_regulation FBXO32 MAPK12 22701436 958019 Positive_regulation FBXO32 MAPK12 23046544 3161193 Positive_regulation FBXO32 MAPK12 23046544 3161223 Positive_regulation FBXO32 MAPK13 21187332 1384649 Positive_regulation FBXO32 MAPK13 22082477 682612 Positive_regulation FBXO32 MAPK13 22701436 958020 Positive_regulation FBXO32 MAPK13 23046544 3161194 Positive_regulation FBXO32 MAPK13 23046544 3161224 Positive_regulation FBXO32 MAPK14 21187332 1384650 Positive_regulation FBXO32 MAPK14 22082477 682613 Positive_regulation FBXO32 MAPK14 22701436 958021 Positive_regulation FBXO32 MAPK14 23046544 3161195 Positive_regulation FBXO32 MAPK14 23046544 3161225 Positive_regulation FBXO32 MAPK15 21187332 1384644 Positive_regulation FBXO32 MAPK15 22082477 682607 Positive_regulation FBXO32 MAPK15 22701436 958015 Positive_regulation FBXO32 MAPK15 23046544 3161189 Positive_regulation FBXO32 MAPK15 23046544 3161219 Positive_regulation FBXO32 MAPK3 21187332 1384651 Positive_regulation FBXO32 MAPK3 22082477 682614 Positive_regulation FBXO32 MAPK3 22701436 958022 Positive_regulation FBXO32 MAPK3 23046544 3161196 Positive_regulation FBXO32 MAPK3 23046544 3161226 Positive_regulation FBXO32 MAPK4 21187332 1384652 Positive_regulation FBXO32 MAPK4 22082477 682615 Positive_regulation FBXO32 MAPK4 22701436 958023 Positive_regulation FBXO32 MAPK4 23046544 3161197 Positive_regulation FBXO32 MAPK4 23046544 3161227 Positive_regulation FBXO32 MAPK6 21187332 1384653 Positive_regulation FBXO32 MAPK6 22082477 682616 Positive_regulation FBXO32 MAPK6 22701436 958024 Positive_regulation FBXO32 MAPK6 23046544 3161198 Positive_regulation FBXO32 MAPK6 23046544 3161228 Positive_regulation FBXO32 MAPK7 21187332 1384654 Positive_regulation FBXO32 MAPK7 22082477 682617 Positive_regulation FBXO32 MAPK7 22701436 958025 Positive_regulation FBXO32 MAPK7 23046544 3161199 Positive_regulation FBXO32 MAPK7 23046544 3161229 Positive_regulation FBXO32 MAPK8 21187332 1384655 Positive_regulation FBXO32 MAPK8 22082477 682618 Positive_regulation FBXO32 MAPK8 22701436 958026 Positive_regulation FBXO32 MAPK8 23046544 3161200 Positive_regulation FBXO32 MAPK8 23046544 3161230 Positive_regulation FBXO32 MAPK9 21187332 1384656 Positive_regulation FBXO32 MAPK9 22082477 682619 Positive_regulation FBXO32 MAPK9 22701436 958027 Positive_regulation FBXO32 MAPK9 23046544 3161201 Positive_regulation FBXO32 MAPK9 23046544 3161231 Positive_regulation FBXO32 MPI 23437325 2756459 Positive_regulation FBXO32 MSTN 24765525 847650 Positive_regulation FBXO32 MSTN 24963862 2983475 Positive_regulation FBXO32 MSTN 25399751 694298 Positive_regulation FBXO32 MYOG 21264243 2494881 Positive_regulation FBXO32 MYOG 24718581 2950865 Positive_regulation FBXO32 NOS1 23268536 740143 Positive_regulation FBXO32 NR3C1 25163459 1239301 Positive_regulation FBXO32 PIK3CA PMC3332414 134763 Positive_regulation FBXO32 PIK3R1 PMC3332414 134764 Positive_regulation FBXO32 POLDIP2 22082477 682606 Positive_regulation FBXO32 POLDIP2 23046544 3161173 Positive_regulation FBXO32 PPARGC1A 22477519 1238977 Positive_regulation FBXO32 PRKAA1 20522589 713920 Positive_regulation FBXO32 PRKAA1 24811453 2962840 Positive_regulation FBXO32 PRKAA1 25625009 3163425 Positive_regulation FBXO32 PRKAA2 20522589 713921 Positive_regulation FBXO32 PRKAA2 24811453 2962841 Positive_regulation FBXO32 PRKAA2 25625009 3163426 Positive_regulation FBXO32 PRKAB1 20522589 713922 Positive_regulation FBXO32 PRKAB1 24811453 2962842 Positive_regulation FBXO32 PRKAB1 25625009 3163427 Positive_regulation FBXO32 PRKAB2 20522589 713923 Positive_regulation FBXO32 PRKAB2 24811453 2962843 Positive_regulation FBXO32 PRKAB2 25625009 3163428 Positive_regulation FBXO32 PRKAG1 20522589 713924 Positive_regulation FBXO32 PRKAG1 24811453 2962844 Positive_regulation FBXO32 PRKAG1 25625009 3163429 Positive_regulation FBXO32 PRKAG2 20522589 713925 Positive_regulation FBXO32 PRKAG2 24811453 2962845 Positive_regulation FBXO32 PRKAG2 25625009 3163430 Positive_regulation FBXO32 RNF19A 23046544 3161171 Positive_regulation FBXO32 RNF19A 23046544 3161172 Positive_regulation FBXO32 RNF19A 23046544 3161185 Positive_regulation FBXO32 RNF19A 23046544 3161218 Positive_regulation FBXO32 RNF19A 23046544 3161246 Positive_regulation FBXO32 SIRT1 22476871 1238657 Positive_regulation FBXO32 SMAD3 24765525 847700 Positive_regulation FBXO32 SREBF1 23226416 2724655 Positive_regulation FBXO32 STK4 23374633 245343 Positive_regulation FBXO32 STK4 23374633 245380 Positive_regulation FBXO32 TCF12 18167544 2382239 Positive_regulation FBXO32 TCF12 19108710 324581 Positive_regulation FBXO32 TCF15 18167544 2382240 Positive_regulation FBXO32 TCF15 19108710 324582 Positive_regulation FBXO32 TCF19 18167544 2382241 Positive_regulation FBXO32 TCF19 19108710 324583 Positive_regulation FBXO32 TCF20 18167544 2382242 Positive_regulation FBXO32 TCF20 19108710 324584 Positive_regulation FBXO32 TCF21 18167544 2382243 Positive_regulation FBXO32 TCF21 19108710 324585 Positive_regulation FBXO32 TCF23 18167544 2382247 Positive_regulation FBXO32 TCF23 19108710 324589 Positive_regulation FBXO32 TCF24 18167544 2382249 Positive_regulation FBXO32 TCF24 19108710 324591 Positive_regulation FBXO32 TCF25 18167544 2382248 Positive_regulation FBXO32 TCF25 19108710 324590 Positive_regulation FBXO32 TCF3 18167544 2382244 Positive_regulation FBXO32 TCF3 19108710 324586 Positive_regulation FBXO32 TCF3 23762056 1073579 Positive_regulation FBXO32 TCF4 18167544 2382245 Positive_regulation FBXO32 TCF4 19108710 324587 Positive_regulation FBXO32 TCF7 18167544 2382246 Positive_regulation FBXO32 TCF7 19108710 324588 Positive_regulation FBXO32 TLR4 22477519 1238894 Positive_regulation FBXO32 TNF 18461174 2388472 Positive_regulation FBXO32 TNF 18461174 2388475 Positive_regulation FBXO32 TNF 22257771 3160822 Positive_regulation FBXO32 TNF 23378678 3609 Positive_regulation FBXO32 TNF 23378678 3612 Positive_regulation FBXO32 TNF 23499576 3204099 Positive_regulation FBXO32 TNF 25566431 1498390 Positive_regulation FBXO32 TNFSF12 22082477 682604 Positive_regulation FBXO32 TNFSF12 22082477 682605 Positive_regulation FBXO32 TNFSF12 24478779 910967 Positive_regulation FBXO32 TRAF6 21187332 1384524 Positive_regulation FBXO32 TRAF6 21187332 1384548 Positive_regulation FBXO32 TRAF6 21187332 1384658 Positive_regulation FBXO32 TRAF6 23665154 1054167 Positive_regulation FBXO32 TRIM63 23046544 3161188 Positive_regulation FBXO32 TUFM 19462004 2417187 Positive_regulation FBXO32 UGCG 21562755 733260 Positive_regulation FBXO32 UGCG 23516508 2768169 Positive_regulation FBXO38 NES 16990251 2022672 Positive_regulation FBXW11 TNF 25071782 913481 Positive_regulation FCER2 TNF 21526166 2513806 Positive_regulation FCER2 TNF 22666666 1920917 Positive_regulation FCGR1A TLR7 20478071 118947 Positive_regulation FCGR3A CEACAM6 25050114 1226928 Positive_regulation FCGR3A TNF 11850593 1632895 Positive_regulation FCGR3A TNF 2137855 1562724 Positive_regulation FCGR3A TNF 2831292 1578485 Positive_regulation FCGR3B EPHB2 8551221 1595780 Positive_regulation FCGRT TNF 20019892 1910304 Positive_regulation FCGRT TNF 20886282 1491452 Positive_regulation FCN2 TNF 24586980 2928516 Positive_regulation FCN2 TNF 24586980 2928551 Positive_regulation FCN2 TNF 24586980 2928552 Positive_regulation FCN2 TNF 24586980 2928553 Positive_regulation FCN2 TNF 24586980 2928680 Positive_regulation FDPS TNF 24179562 2372295 Positive_regulation FEV ARSA 20358028 35607 Positive_regulation FEV ARSA 21461252 35686 Positive_regulation FFAR1 FAS 21088697 936171 Positive_regulation FFAR4 FAS 21088697 936168 Positive_regulation FFAR4 FAS 24674717 1667858 Positive_regulation FFAR4 FAS 25076939 880995 Positive_regulation FFAR4 FAS 25076939 880996 Positive_regulation FFAR4 FAS 25076939 880999 Positive_regulation FGB ANGPT1 24013716 2842159 Positive_regulation FGB ITGB2 7744962 1440107 Positive_regulation FGB PLAT 10831618 1258177 Positive_regulation FGB PLAU 23481605 1732226 Positive_regulation FGB TNF 23208413 2110584 Positive_regulation FGB TNF 7519620 1436161 Positive_regulation FGD3 HOPX 24493799 1574859 Positive_regulation FGF1 EPHB2 11449001 1273107 Positive_regulation FGF1 EPHB2 11449001 1273284 Positive_regulation FGF1 EPHB2 19333377 2409578 Positive_regulation FGF1 EPHB2 21418646 305176 Positive_regulation FGF1 EPHB2 22235335 2585937 Positive_regulation FGF1 EPHB2 23213390 168089 Positive_regulation FGF1 EPHB2 24744103 494700 Positive_regulation FGF1 EPHB2 24744103 494773 Positive_regulation FGF1 EPHB2 24744103 494845 Positive_regulation FGF1 FGFBP1 22111880 1864204 Positive_regulation FGF1 IFI27 12177046 1286067 Positive_regulation FGF1 MSX1 19913215 96424 Positive_regulation FGF1 MSX1 22383889 2332092 Positive_regulation FGF1 MSX1 24550838 963848 Positive_regulation FGF1 PLAU 1645739 1327467 Positive_regulation FGF1 TNF 10704075 1736863 Positive_regulation FGF10 EPHB2 11449001 1273108 Positive_regulation FGF10 EPHB2 11449001 1273285 Positive_regulation FGF10 EPHB2 19333377 2409579 Positive_regulation FGF10 EPHB2 21418646 305180 Positive_regulation FGF10 EPHB2 22235335 2585938 Positive_regulation FGF10 EPHB2 23213390 168093 Positive_regulation FGF10 EPHB2 24744103 494701 Positive_regulation FGF10 EPHB2 24744103 494774 Positive_regulation FGF10 EPHB2 24744103 494847 Positive_regulation FGF10 FGFBP1 22111880 1864205 Positive_regulation FGF10 IFI27 12177046 1286068 Positive_regulation FGF10 MSX1 19913215 96434 Positive_regulation FGF10 MSX1 22383889 2332094 Positive_regulation FGF10 MSX1 24550838 963853 Positive_regulation FGF10 PLAU 1645739 1327468 Positive_regulation FGF11 EPHB2 11449001 1273109 Positive_regulation FGF11 EPHB2 11449001 1273286 Positive_regulation FGF11 EPHB2 19333377 2409580 Positive_regulation FGF11 EPHB2 21418646 305184 Positive_regulation FGF11 EPHB2 22235335 2585939 Positive_regulation FGF11 EPHB2 23213390 168097 Positive_regulation FGF11 EPHB2 24744103 494702 Positive_regulation FGF11 EPHB2 24744103 494775 Positive_regulation FGF11 EPHB2 24744103 494849 Positive_regulation FGF11 FGFBP1 22111880 1864206 Positive_regulation FGF11 IFI27 12177046 1286069 Positive_regulation FGF11 MSX1 19913215 96444 Positive_regulation FGF11 MSX1 22383889 2332096 Positive_regulation FGF11 MSX1 24550838 963858 Positive_regulation FGF11 PLAU 1645739 1327469 Positive_regulation FGF12 EPHB2 11449001 1273110 Positive_regulation FGF12 EPHB2 11449001 1273287 Positive_regulation FGF12 EPHB2 19333377 2409581 Positive_regulation FGF12 EPHB2 21418646 305188 Positive_regulation FGF12 EPHB2 22235335 2585940 Positive_regulation FGF12 EPHB2 23213390 168101 Positive_regulation FGF12 EPHB2 24744103 494703 Positive_regulation FGF12 EPHB2 24744103 494776 Positive_regulation FGF12 EPHB2 24744103 494851 Positive_regulation FGF12 FGFBP1 22111880 1864207 Positive_regulation FGF12 IFI27 12177046 1286070 Positive_regulation FGF12 MSX1 19913215 96454 Positive_regulation FGF12 MSX1 22383889 2332098 Positive_regulation FGF12 MSX1 24550838 963863 Positive_regulation FGF12 PLAU 1645739 1327470 Positive_regulation FGF13 EPHB2 11449001 1273111 Positive_regulation FGF13 EPHB2 11449001 1273288 Positive_regulation FGF13 EPHB2 19333377 2409582 Positive_regulation FGF13 EPHB2 21418646 305192 Positive_regulation FGF13 EPHB2 22235335 2585941 Positive_regulation FGF13 EPHB2 23213390 168105 Positive_regulation FGF13 EPHB2 24744103 494704 Positive_regulation FGF13 EPHB2 24744103 494777 Positive_regulation FGF13 EPHB2 24744103 494853 Positive_regulation FGF13 FGFBP1 22111880 1864208 Positive_regulation FGF13 IFI27 12177046 1286071 Positive_regulation FGF13 MSX1 19913215 96464 Positive_regulation FGF13 MSX1 22383889 2332100 Positive_regulation FGF13 MSX1 24550838 963868 Positive_regulation FGF13 PLAU 1645739 1327471 Positive_regulation FGF14 EPHB2 11449001 1273112 Positive_regulation FGF14 EPHB2 11449001 1273289 Positive_regulation FGF14 EPHB2 19333377 2409583 Positive_regulation FGF14 EPHB2 21418646 305196 Positive_regulation FGF14 EPHB2 22235335 2585942 Positive_regulation FGF14 EPHB2 23213390 168109 Positive_regulation FGF14 EPHB2 24744103 494705 Positive_regulation FGF14 EPHB2 24744103 494778 Positive_regulation FGF14 EPHB2 24744103 494855 Positive_regulation FGF14 FGFBP1 22111880 1864209 Positive_regulation FGF14 IFI27 12177046 1286072 Positive_regulation FGF14 MSX1 19913215 96474 Positive_regulation FGF14 MSX1 22383889 2332102 Positive_regulation FGF14 MSX1 24550838 963873 Positive_regulation FGF14 PLAU 1645739 1327472 Positive_regulation FGF16 EPHB2 11449001 1273113 Positive_regulation FGF16 EPHB2 11449001 1273290 Positive_regulation FGF16 EPHB2 19333377 2409584 Positive_regulation FGF16 EPHB2 21418646 305200 Positive_regulation FGF16 EPHB2 22235335 2585943 Positive_regulation FGF16 EPHB2 23213390 168113 Positive_regulation FGF16 EPHB2 24744103 494706 Positive_regulation FGF16 EPHB2 24744103 494779 Positive_regulation FGF16 EPHB2 24744103 494857 Positive_regulation FGF16 FGFBP1 22111880 1864210 Positive_regulation FGF16 IFI27 12177046 1286073 Positive_regulation FGF16 MSX1 19913215 96484 Positive_regulation FGF16 MSX1 22383889 2332104 Positive_regulation FGF16 MSX1 24550838 963878 Positive_regulation FGF16 PLAU 1645739 1327473 Positive_regulation FGF17 EPHB2 11449001 1273114 Positive_regulation FGF17 EPHB2 11449001 1273291 Positive_regulation FGF17 EPHB2 19333377 2409585 Positive_regulation FGF17 EPHB2 21418646 305204 Positive_regulation FGF17 EPHB2 22235335 2585944 Positive_regulation FGF17 EPHB2 23213390 168117 Positive_regulation FGF17 EPHB2 24744103 494707 Positive_regulation FGF17 EPHB2 24744103 494780 Positive_regulation FGF17 EPHB2 24744103 494859 Positive_regulation FGF17 FGFBP1 22111880 1864211 Positive_regulation FGF17 IFI27 12177046 1286074 Positive_regulation FGF17 MSX1 19913215 96494 Positive_regulation FGF17 MSX1 22383889 2332106 Positive_regulation FGF17 MSX1 24550838 963883 Positive_regulation FGF17 PLAU 1645739 1327474 Positive_regulation FGF18 EPHB2 11449001 1273115 Positive_regulation FGF18 EPHB2 11449001 1273292 Positive_regulation FGF18 EPHB2 19333377 2409586 Positive_regulation FGF18 EPHB2 21418646 305208 Positive_regulation FGF18 EPHB2 22235335 2585945 Positive_regulation FGF18 EPHB2 23213390 168121 Positive_regulation FGF18 EPHB2 24744103 494708 Positive_regulation FGF18 EPHB2 24744103 494781 Positive_regulation FGF18 EPHB2 24744103 494861 Positive_regulation FGF18 FGFBP1 22111880 1864212 Positive_regulation FGF18 IFI27 12177046 1286075 Positive_regulation FGF18 MSX1 19913215 96504 Positive_regulation FGF18 MSX1 22383889 2332108 Positive_regulation FGF18 MSX1 24550838 963888 Positive_regulation FGF18 PLAU 1645739 1327475 Positive_regulation FGF19 EPHB2 11449001 1273116 Positive_regulation FGF19 EPHB2 11449001 1273293 Positive_regulation FGF19 EPHB2 19333377 2409587 Positive_regulation FGF19 EPHB2 21418646 305212 Positive_regulation FGF19 EPHB2 22235335 2585946 Positive_regulation FGF19 EPHB2 23213390 168125 Positive_regulation FGF19 EPHB2 24744103 494709 Positive_regulation FGF19 EPHB2 24744103 494782 Positive_regulation FGF19 EPHB2 24744103 494863 Positive_regulation FGF19 FGFBP1 22111880 1864213 Positive_regulation FGF19 IFI27 12177046 1286076 Positive_regulation FGF19 MSX1 19913215 96514 Positive_regulation FGF19 MSX1 22383889 2332110 Positive_regulation FGF19 MSX1 24550838 963893 Positive_regulation FGF19 PLAU 1645739 1327476 Positive_regulation FGF2 ANGPT1 21637825 2526696 Positive_regulation FGF2 ANGPT1 22409996 124963 Positive_regulation FGF2 CCND1 24503018 784370 Positive_regulation FGF2 EDN2 23469133 2762015 Positive_regulation FGF2 EDN2 23469133 2762016 Positive_regulation FGF2 EDN2 23469133 2762017 Positive_regulation FGF2 ENPP1 19247458 1909008 Positive_regulation FGF2 EPHB2 11449001 1273117 Positive_regulation FGF2 EPHB2 11449001 1273294 Positive_regulation FGF2 EPHB2 19333377 2409588 Positive_regulation FGF2 EPHB2 19597471 2125659 Positive_regulation FGF2 EPHB2 20886037 2476108 Positive_regulation FGF2 EPHB2 21418646 305216 Positive_regulation FGF2 EPHB2 22235335 2585947 Positive_regulation FGF2 EPHB2 22298785 1201052 Positive_regulation FGF2 EPHB2 23071632 2703615 Positive_regulation FGF2 EPHB2 23213390 168129 Positive_regulation FGF2 EPHB2 23793469 31283 Positive_regulation FGF2 EPHB2 23967228 2835090 Positive_regulation FGF2 EPHB2 24194720 962687 Positive_regulation FGF2 EPHB2 24744103 494710 Positive_regulation FGF2 EPHB2 24744103 494783 Positive_regulation FGF2 EPHB2 24744103 494865 Positive_regulation FGF2 EPHB2 24827991 2969850 Positive_regulation FGF2 EPHB2 24848261 2972375 Positive_regulation FGF2 EPHB2 24980830 2194854 Positive_regulation FGF2 EPHB2 25210890 3006730 Positive_regulation FGF2 FGFBP1 22111880 1864214 Positive_regulation FGF2 FGFBP1 22111880 1864273 Positive_regulation FGF2 IFI27 12177046 1286077 Positive_regulation FGF2 MAP2K6 19597471 2125665 Positive_regulation FGF2 MAP2K6 20886037 2476114 Positive_regulation FGF2 MAP2K6 22870983 288751 Positive_regulation FGF2 MAP2K6 22870983 288883 Positive_regulation FGF2 MAP2K6 22870983 288986 Positive_regulation FGF2 MMP28 23227251 2725770 Positive_regulation FGF2 MMP28 24260208 2882646 Positive_regulation FGF2 MMP28 8554978 445134 Positive_regulation FGF2 MMP7 16286510 1325430 Positive_regulation FGF2 MMP7 23227251 2725789 Positive_regulation FGF2 MMP7 24260208 2882665 Positive_regulation FGF2 MMP7 8554978 445149 Positive_regulation FGF2 MSX1 19913215 96524 Positive_regulation FGF2 MSX1 22383889 2332112 Positive_regulation FGF2 MSX1 24550838 963898 Positive_regulation FGF2 PLAU 1645739 1327477 Positive_regulation FGF2 S100B 22276098 2589896 Positive_regulation FGF2 S100B 22276098 2589897 Positive_regulation FGF2 S100B 22276098 2589898 Positive_regulation FGF2 S100B 22276098 2589943 Positive_regulation FGF2 S100B 22276098 2589944 Positive_regulation FGF2 S100B 22276098 2589953 Positive_regulation FGF2 S100B 22276098 2589954 Positive_regulation FGF2 S100B 22276098 2589955 Positive_regulation FGF2 TNF 19014534 2232732 Positive_regulation FGF2 TNF 19014534 2232733 Positive_regulation FGF2 TNF 19467159 3117922 Positive_regulation FGF2 TNF 8601593 1450639 Positive_regulation FGF20 EPHB2 11449001 1273118 Positive_regulation FGF20 EPHB2 11449001 1273295 Positive_regulation FGF20 EPHB2 19333377 2409589 Positive_regulation FGF20 EPHB2 21418646 305220 Positive_regulation FGF20 EPHB2 22235335 2585948 Positive_regulation FGF20 EPHB2 23213390 168133 Positive_regulation FGF20 EPHB2 24744103 494711 Positive_regulation FGF20 EPHB2 24744103 494784 Positive_regulation FGF20 EPHB2 24744103 494867 Positive_regulation FGF20 FGFBP1 22111880 1864215 Positive_regulation FGF20 IFI27 12177046 1286078 Positive_regulation FGF20 MSX1 19913215 96534 Positive_regulation FGF20 MSX1 22383889 2332114 Positive_regulation FGF20 MSX1 24550838 963903 Positive_regulation FGF20 PLAU 1645739 1327478 Positive_regulation FGF21 EPHB2 11449001 1273119 Positive_regulation FGF21 EPHB2 11449001 1273296 Positive_regulation FGF21 EPHB2 19333377 2409590 Positive_regulation FGF21 EPHB2 21418646 305224 Positive_regulation FGF21 EPHB2 22235335 2585949 Positive_regulation FGF21 EPHB2 23213390 168137 Positive_regulation FGF21 EPHB2 24744103 494712 Positive_regulation FGF21 EPHB2 24744103 494785 Positive_regulation FGF21 EPHB2 24744103 494869 Positive_regulation FGF21 EPHB2 24848261 2972379 Positive_regulation FGF21 FGFBP1 22111880 1864216 Positive_regulation FGF21 GLP1R 24052894 20560 Positive_regulation FGF21 IFI27 12177046 1286079 Positive_regulation FGF21 MSX1 19913215 96544 Positive_regulation FGF21 MSX1 22383889 2332116 Positive_regulation FGF21 MSX1 24550838 963908 Positive_regulation FGF21 PGC 20730630 616141 Positive_regulation FGF21 PGC 21331285 1669714 Positive_regulation FGF21 PGC 21331285 1669716 Positive_regulation FGF21 PGC 24744913 2251862 Positive_regulation FGF21 PLAU 1645739 1327479 Positive_regulation FGF22 EPHB2 11449001 1273120 Positive_regulation FGF22 EPHB2 11449001 1273297 Positive_regulation FGF22 EPHB2 19333377 2409591 Positive_regulation FGF22 EPHB2 21418646 305228 Positive_regulation FGF22 EPHB2 22235335 2585950 Positive_regulation FGF22 EPHB2 23213390 168141 Positive_regulation FGF22 EPHB2 24744103 494713 Positive_regulation FGF22 EPHB2 24744103 494786 Positive_regulation FGF22 EPHB2 24744103 494871 Positive_regulation FGF22 FGFBP1 22111880 1864217 Positive_regulation FGF22 IFI27 12177046 1286080 Positive_regulation FGF22 MSX1 19913215 96554 Positive_regulation FGF22 MSX1 22383889 2332118 Positive_regulation FGF22 MSX1 24550838 963913 Positive_regulation FGF22 PLAU 1645739 1327480 Positive_regulation FGF23 CYP24A1 20730630 616407 Positive_regulation FGF23 CYP24A1 20730630 616556 Positive_regulation FGF23 EPHB2 11449001 1273121 Positive_regulation FGF23 EPHB2 11449001 1273298 Positive_regulation FGF23 EPHB2 19333377 2409592 Positive_regulation FGF23 EPHB2 21418646 305232 Positive_regulation FGF23 EPHB2 22235335 2585951 Positive_regulation FGF23 EPHB2 23213390 168145 Positive_regulation FGF23 EPHB2 24695641 2948301 Positive_regulation FGF23 EPHB2 24744103 494714 Positive_regulation FGF23 EPHB2 24744103 494787 Positive_regulation FGF23 EPHB2 24744103 494873 Positive_regulation FGF23 FGFBP1 22111880 1864218 Positive_regulation FGF23 IFI27 12177046 1286081 Positive_regulation FGF23 MSX1 19913215 96564 Positive_regulation FGF23 MSX1 22383889 2332120 Positive_regulation FGF23 MSX1 24550838 963918 Positive_regulation FGF23 PLAU 1645739 1327481 Positive_regulation FGF3 EPHB2 11449001 1273122 Positive_regulation FGF3 EPHB2 11449001 1273299 Positive_regulation FGF3 EPHB2 19333377 2409593 Positive_regulation FGF3 EPHB2 21418646 305236 Positive_regulation FGF3 EPHB2 22235335 2585952 Positive_regulation FGF3 EPHB2 23213390 168149 Positive_regulation FGF3 EPHB2 24744103 494715 Positive_regulation FGF3 EPHB2 24744103 494788 Positive_regulation FGF3 EPHB2 24744103 494875 Positive_regulation FGF3 FGFBP1 22111880 1864219 Positive_regulation FGF3 IFI27 12177046 1286082 Positive_regulation FGF3 MSX1 19913215 96574 Positive_regulation FGF3 MSX1 22383889 2332122 Positive_regulation FGF3 MSX1 24550838 963923 Positive_regulation FGF3 PLAU 1645739 1327482 Positive_regulation FGF4 EPHB2 11449001 1273123 Positive_regulation FGF4 EPHB2 11449001 1273300 Positive_regulation FGF4 EPHB2 19333377 2409594 Positive_regulation FGF4 EPHB2 21418646 305240 Positive_regulation FGF4 EPHB2 22235335 2585953 Positive_regulation FGF4 EPHB2 23213390 168153 Positive_regulation FGF4 EPHB2 23967228 2835118 Positive_regulation FGF4 EPHB2 24643025 2935531 Positive_regulation FGF4 EPHB2 24643025 2935556 Positive_regulation FGF4 EPHB2 24744103 494716 Positive_regulation FGF4 EPHB2 24744103 494789 Positive_regulation FGF4 EPHB2 24744103 494877 Positive_regulation FGF4 EPHB2 24752320 2956555 Positive_regulation FGF4 FGFBP1 22111880 1864220 Positive_regulation FGF4 IFI27 12177046 1286083 Positive_regulation FGF4 MSX1 19913215 96584 Positive_regulation FGF4 MSX1 22383889 2332124 Positive_regulation FGF4 MSX1 24550838 963928 Positive_regulation FGF4 PLAU 1645739 1327483 Positive_regulation FGF5 EPHB2 11449001 1273124 Positive_regulation FGF5 EPHB2 11449001 1273301 Positive_regulation FGF5 EPHB2 19333377 2409595 Positive_regulation FGF5 EPHB2 21418646 305244 Positive_regulation FGF5 EPHB2 22235335 2585954 Positive_regulation FGF5 EPHB2 23213390 168157 Positive_regulation FGF5 EPHB2 24744103 494717 Positive_regulation FGF5 EPHB2 24744103 494790 Positive_regulation FGF5 EPHB2 24744103 494879 Positive_regulation FGF5 FGFBP1 22111880 1864221 Positive_regulation FGF5 IFI27 12177046 1286084 Positive_regulation FGF5 MSX1 19913215 96594 Positive_regulation FGF5 MSX1 22383889 2332126 Positive_regulation FGF5 MSX1 24550838 963933 Positive_regulation FGF5 PLAU 1645739 1327484 Positive_regulation FGF6 EPHB2 11449001 1273125 Positive_regulation FGF6 EPHB2 11449001 1273302 Positive_regulation FGF6 EPHB2 19333377 2409596 Positive_regulation FGF6 EPHB2 21418646 305248 Positive_regulation FGF6 EPHB2 22235335 2585955 Positive_regulation FGF6 EPHB2 23213390 168161 Positive_regulation FGF6 EPHB2 24744103 494718 Positive_regulation FGF6 EPHB2 24744103 494791 Positive_regulation FGF6 EPHB2 24744103 494881 Positive_regulation FGF6 FGFBP1 22111880 1864222 Positive_regulation FGF6 IFI27 12177046 1286085 Positive_regulation FGF6 MSX1 19913215 96604 Positive_regulation FGF6 MSX1 22383889 2332128 Positive_regulation FGF6 MSX1 24550838 963938 Positive_regulation FGF6 PLAU 1645739 1327485 Positive_regulation FGF7 EPHB2 11449001 1273126 Positive_regulation FGF7 EPHB2 11449001 1273303 Positive_regulation FGF7 EPHB2 15972105 298228 Positive_regulation FGF7 EPHB2 19333377 2409597 Positive_regulation FGF7 EPHB2 21418646 305252 Positive_regulation FGF7 EPHB2 22235335 2585956 Positive_regulation FGF7 EPHB2 23213390 168165 Positive_regulation FGF7 EPHB2 24124521 2865990 Positive_regulation FGF7 EPHB2 24744103 494719 Positive_regulation FGF7 EPHB2 24744103 494792 Positive_regulation FGF7 EPHB2 24744103 494883 Positive_regulation FGF7 FGFBP1 22111880 1864223 Positive_regulation FGF7 IFI27 12177046 1286086 Positive_regulation FGF7 MSX1 19913215 96614 Positive_regulation FGF7 MSX1 22383889 2332130 Positive_regulation FGF7 MSX1 24550838 963943 Positive_regulation FGF7 PLAU 1645739 1327486 Positive_regulation FGF8 EPHB2 11449001 1273127 Positive_regulation FGF8 EPHB2 11449001 1273304 Positive_regulation FGF8 EPHB2 19333377 2409598 Positive_regulation FGF8 EPHB2 21418646 305256 Positive_regulation FGF8 EPHB2 22235335 2585957 Positive_regulation FGF8 EPHB2 23213390 168169 Positive_regulation FGF8 EPHB2 24744103 494720 Positive_regulation FGF8 EPHB2 24744103 494793 Positive_regulation FGF8 EPHB2 24744103 494885 Positive_regulation FGF8 FGFBP1 22111880 1864224 Positive_regulation FGF8 IFI27 12177046 1286087 Positive_regulation FGF8 MSX1 19913215 96624 Positive_regulation FGF8 MSX1 22383889 2332132 Positive_regulation FGF8 MSX1 24550838 963948 Positive_regulation FGF8 PLAU 1645739 1327487 Positive_regulation FGF9 EPHB2 11449001 1273128 Positive_regulation FGF9 EPHB2 11449001 1273305 Positive_regulation FGF9 EPHB2 19333377 2409599 Positive_regulation FGF9 EPHB2 21418646 305260 Positive_regulation FGF9 EPHB2 22235335 2585958 Positive_regulation FGF9 EPHB2 23213390 168173 Positive_regulation FGF9 EPHB2 24744103 494721 Positive_regulation FGF9 EPHB2 24744103 494794 Positive_regulation FGF9 EPHB2 24744103 494887 Positive_regulation FGF9 FGFBP1 22111880 1864225 Positive_regulation FGF9 IFI27 12177046 1286088 Positive_regulation FGF9 MSX1 19913215 96634 Positive_regulation FGF9 MSX1 22383889 2332134 Positive_regulation FGF9 MSX1 23176204 533674 Positive_regulation FGF9 MSX1 24550838 963953 Positive_regulation FGF9 PLAU 1645739 1327488 Positive_regulation FGFR1 CCND1 19330026 2124989 Positive_regulation FGFR1 CCND1 19330026 2124993 Positive_regulation FGFR1 CCND1 19330026 2125000 Positive_regulation FGFR1 CCND1 24503018 784371 Positive_regulation FGFR1 EPHB2 23583981 1951376 Positive_regulation FGFR1 EPHB2 24752320 2956556 Positive_regulation FGFR1 EPHB2 24848261 2972376 Positive_regulation FGFR1 FZD4 25277175 2202885 Positive_regulation FGFR1 HRH1 23497494 1998402 Positive_regulation FGFR1 KLF9 20554758 1777905 Positive_regulation FGFR1 KLF9 20554758 1777906 Positive_regulation FGFR1 KLF9 20554758 1777907 Positive_regulation FGFR1 KLF9 20554758 1777911 Positive_regulation FGFR1 KLF9 20554758 1777912 Positive_regulation FGFR1 KLF9 20554758 1777918 Positive_regulation FGFR1 MAP2K6 17277739 1906323 Positive_regulation FGFR1 MMP28 23227251 2725796 Positive_regulation FGFR1 MMP28 24260208 2882672 Positive_regulation FGFR1 MMP7 23227251 2725811 Positive_regulation FGFR1 MMP7 24260208 2882687 Positive_regulation FGFR1 S100B 22276098 2589814 Positive_regulation FGFR1 S100B 22276098 2589899 Positive_regulation FGFR1 S100B 22276098 2589900 Positive_regulation FGFR1 S100B 22276098 2589901 Positive_regulation FGFR1 S100B 22276098 2589945 Positive_regulation FGFR1 S100B 22276098 2589946 Positive_regulation FGFR1 S100B 22276098 2589956 Positive_regulation FGFR1 S100B 22276098 2589957 Positive_regulation FGFR1 S100B 22276098 2589958 Positive_regulation FGFR1OP NES 15251038 277767 Positive_regulation FGFR2 EPHB2 15972105 298229 Positive_regulation FGFR2 EPHB2 24752320 2956557 Positive_regulation FGFR2 MAP2K6 17277739 1906330 Positive_regulation FGFR2 MMP28 23227251 2725818 Positive_regulation FGFR2 MMP28 24260208 2882694 Positive_regulation FGFR2 MMP7 23227251 2725833 Positive_regulation FGFR2 MMP7 24260208 2882709 Positive_regulation FGFR3 ALDH2 PMC4212304 3206233 Positive_regulation FGFR3 ALDH2 PMC4212304 3206270 Positive_regulation FGFR3 EPHB2 19088846 2402494 Positive_regulation FGFR3 EPHB2 19088846 2402499 Positive_regulation FGFR3 EPHB2 21559295 2518096 Positive_regulation FGFR3 EPHB2 24752320 2956558 Positive_regulation FGFR3 MAP2K6 17277739 1906337 Positive_regulation FGFR3 MMP28 23227251 2725840 Positive_regulation FGFR3 MMP28 24260208 2882716 Positive_regulation FGFR3 MMP7 23227251 2725855 Positive_regulation FGFR3 MMP7 24260208 2882731 Positive_regulation FGFR3 NES 21278733 1966522 Positive_regulation FGFR3 NES 21278733 1966535 Positive_regulation FGFR3 TNF 22723832 2654766 Positive_regulation FGFR3 TNF 22723832 2654770 Positive_regulation FGFR4 EPHB2 24752320 2956559 Positive_regulation FGFR4 FOXO1 21253475 3127967 Positive_regulation FGFR4 MAP2K6 17277739 1906344 Positive_regulation FGFR4 MMP28 23227251 2725862 Positive_regulation FGFR4 MMP28 24260208 2882738 Positive_regulation FGFR4 MMP7 23227251 2725877 Positive_regulation FGFR4 MMP7 24260208 2882753 Positive_regulation FGL2 TNF 21750671 3052224 Positive_regulation FGR TNF 24395887 1574420 Positive_regulation FGR TNF 7519620 1436168 Positive_regulation FGR TNF 7519620 1436169 Positive_regulation FHL1 ACD 16351711 231765 Positive_regulation FHL1 CRTC1 22068328 1904099 Positive_regulation FHL1 FAR1 18670649 2305640 Positive_regulation FHL1 FHL2 20529219 34659 Positive_regulation FHL1 FHL3 20529219 34660 Positive_regulation FHL1 FURIN 21880124 366548 Positive_regulation FHL1 LGALS4 20230615 1007130 Positive_regulation FHL1 POT1 16351711 231763 Positive_regulation FHL1 RAD50 16351711 231766 Positive_regulation FHL1 TERF1 16351711 231760 Positive_regulation FHL1 TERF2 16351711 231761 Positive_regulation FHL1 TERF2IP 16351711 231764 Positive_regulation FHL1 TINF2 16351711 231762 Positive_regulation FHOD1 STK39 24086398 2854020 Positive_regulation FIGF PPBP 20652010 1672286 Positive_regulation FIGF TLR7 25580369 1490974 Positive_regulation FIGF TNF 23243599 2161899 Positive_regulation FIP1L1 EPHB2 24359404 538658 Positive_regulation FKBP10 TNF 21368763 1987129 Positive_regulation FKBP11 TNF 21368763 1987131 Positive_regulation FKBP14 TNF 21368763 1987133 Positive_regulation FKBP15 TNF 21368763 1987135 Positive_regulation FKBP2 TNF 21368763 1987137 Positive_regulation FKBP3 TNF 21368763 1987139 Positive_regulation FKBP4 TNF 21368763 1987141 Positive_regulation FKBP5 TNF 21368763 1987143 Positive_regulation FKBP6 TNF 21368763 1987145 Positive_regulation FKBP7 TNF 21368763 1987147 Positive_regulation FKBP8 TNF 21368763 1987149 Positive_regulation FKBP9 TNF 21368763 1987151 Positive_regulation FLG AHR 24161567 1492788 Positive_regulation FLG AQP3 24260356 2883982 Positive_regulation FLG CA2 1691191 1332155 Positive_regulation FLG CA2 7678013 1438671 Positive_regulation FLG CA2 7678013 1438673 Positive_regulation FLG ETS1 21915322 2553292 Positive_regulation FLG IL17A 24116291 204389 Positive_regulation FLG IL22 24116291 204403 Positive_regulation FLG IL4 24116291 204377 Positive_regulation FLG MAFB 21072181 2481239 Positive_regulation FLG RCHY1 23235527 1631911 Positive_regulation FLG TGM1 24116231 2865894 Positive_regulation FLI1 CTGF 21760921 2535982 Positive_regulation FLI1 EPHB2 15972796 2016772 Positive_regulation FLI1 KRT38 18648544 2393681 Positive_regulation FLI1 PODXL 18648544 2393688 Positive_regulation FLNA CAPN8 23977256 2839505 Positive_regulation FLNA CAPN8 25220605 3145783 Positive_regulation FLT1 EPHB2 18931684 1960493 Positive_regulation FLT1 EPHB2 19834490 546394 Positive_regulation FLT3 EPHB2 20698720 745672 Positive_regulation FLT3LG TLR7 25003083 647429 Positive_regulation FLT4 TNF 24124909 1667201 Positive_regulation FMR1 CCND1 23640459 561709 Positive_regulation FN1 ANGPT1 16157706 1324024 Positive_regulation FN1 ANGPT1 24013716 2842160 Positive_regulation FN1 CLU 25148511 3002018 Positive_regulation FN1 CLU 25148511 3002019 Positive_regulation FN1 CTGF 14668046 830424 Positive_regulation FN1 CTGF 14668046 830427 Positive_regulation FN1 CTGF 17579708 2376561 Positive_regulation FN1 CTGF 18401458 831379 Positive_regulation FN1 CTGF 18789696 3190779 Positive_regulation FN1 CTGF 19214781 1478507 Positive_regulation FN1 CTGF 19259423 488890 Positive_regulation FN1 CTGF 20497571 285106 Positive_regulation FN1 CTGF 20497571 285119 Positive_regulation FN1 CTGF 20497571 285120 Positive_regulation FN1 CTGF 21152444 2487089 Positive_regulation FN1 CTGF 21760921 2536008 Positive_regulation FN1 CTGF 23946690 1716061 Positive_regulation FN1 CTGF 23950936 2832992 Positive_regulation FN1 CTGF 23950936 2832993 Positive_regulation FN1 CTGF 24015303 2842659 Positive_regulation FN1 CTGF 24348987 2896526 Positive_regulation FN1 CTGF 24348987 2896527 Positive_regulation FN1 CTGF 24558600 1154251 Positive_regulation FN1 CTGF 24705265 985532 Positive_regulation FN1 ID1 24970809 2193986 Positive_regulation FN1 ID1 25028095 1875767 Positive_regulation FN1 ITGAL 9298996 1463461 Positive_regulation FN1 LAMB3 9852164 1472526 Positive_regulation FN1 MAP2K6 24752320 2956549 Positive_regulation FN1 MMP28 23259712 856299 Positive_regulation FN1 MMP7 23259712 856314 Positive_regulation FN1 S100B 24324515 824422 Positive_regulation FN1 TNF 18053242 1695762 Positive_regulation FN1 TNF 18053242 1695765 Positive_regulation FN1 TNF 22426696 14548 Positive_regulation FN1 TNF 22461911 2614084 Positive_regulation FN1 TNF 23133440 904847 Positive_regulation FN1 TNF 24977073 1154288 Positive_regulation FN1 TNF 7806579 1441879 Positive_regulation FN1 WIF1 20573255 1856523 Positive_regulation FNDC5 PGC 22237023 1988071 Positive_regulation FNDC5 PGC 23593248 2780462 Positive_regulation FNDC5 PGC 23593248 2780463 Positive_regulation FNDC5 PGC 24298283 1073823 Positive_regulation FNDC5 PGC 24864142 1074133 Positive_regulation FNDC5 PGC 24864142 1074136 Positive_regulation FNDC5 PGC 24999318 869616 Positive_regulation FNDC5 PGC 24999318 869620 Positive_regulation FNDC5 PGC 25057322 1613721 Positive_regulation FNDC5 PGC 25517117 3035012 Positive_regulation FNTA MAP2K6 19404317 1719336 Positive_regulation FNTB MAP2K6 19404317 1719343 Positive_regulation FOLH1 AGR2 22457627 3055904 Positive_regulation FOLR1 FUBP1 20485488 2271768 Positive_regulation FOLR1 GTF2B 20485488 2271769 Positive_regulation FOLR1 PARP1 20069122 1671727 Positive_regulation FOLR1 PARP10 20069122 1671722 Positive_regulation FOLR1 PARP11 20069122 1671719 Positive_regulation FOLR1 PARP12 20069122 1671720 Positive_regulation FOLR1 PARP14 20069122 1671731 Positive_regulation FOLR1 PARP15 20069122 1671725 Positive_regulation FOLR1 PARP16 20069122 1671723 Positive_regulation FOLR1 PARP2 20069122 1671729 Positive_regulation FOLR1 PARP3 20069122 1671730 Positive_regulation FOLR1 PARP4 20069122 1671728 Positive_regulation FOLR1 PARP6 20069122 1671726 Positive_regulation FOLR1 PARP8 20069122 1671724 Positive_regulation FOLR1 PARP9 20069122 1671721 Positive_regulation FOLR1 PHKA2 23946717 2298766 Positive_regulation FOLR1 PHKA2 25268481 3011479 Positive_regulation FOLR1 PHKA2 25268481 3011483 Positive_regulation FOLR1 PKM 22140559 2576685 Positive_regulation FOLR1 PKM 22922757 1931679 Positive_regulation FOLR1 PRKACB 23967182 2834748 Positive_regulation FOLR1 PRKACG 23967182 2834749 Positive_regulation FOLR1 PRKAR1A 23967182 2834750 Positive_regulation FOLR1 PRKAR1B 23967182 2834751 Positive_regulation FOLR1 PRKAR2A 23967182 2834752 Positive_regulation FOLR1 PRKAR2B 23967182 2834753 Positive_regulation FOLR1 RNF20 21811414 2325617 Positive_regulation FOLR1 SLC22A12 20453258 27294 Positive_regulation FOLR1 SLC22A12 24155978 2871928 Positive_regulation FOS EFNB1 22879882 2672829 Positive_regulation FOS EPHB2 10648566 1255389 Positive_regulation FOS EPHB2 14735164 424166 Positive_regulation FOS EPHB2 19789270 2047813 Positive_regulation FOS EPHB2 19925682 327061 Positive_regulation FOS EPHB2 19956756 2432693 Positive_regulation FOS EPHB2 20652960 3170897 Positive_regulation FOS EPHB2 22399974 3158765 Positive_regulation FOS EPHB2 22427889 2610577 Positive_regulation FOS EPHB2 22427889 2610589 Positive_regulation FOS EPHB2 22564826 159966 Positive_regulation FOS EPHB2 23365596 817149 Positive_regulation FOS EPHB2 23633945 3060773 Positive_regulation FOS EPHB2 23843873 821192 Positive_regulation FOS EPHB2 23946780 2165345 Positive_regulation FOS EPHB2 24086787 2372160 Positive_regulation FOS EPHB2 24116275 204248 Positive_regulation FOS EPHB2 24444335 295677 Positive_regulation FOS EPHB2 24737575 810059 Positive_regulation FOS EPHB2 24743235 2954903 Positive_regulation FOS EPHB2 25068118 3167132 Positive_regulation FOS MAP2K6 16390551 3106025 Positive_regulation FOS MAP2K6 21960960 933831 Positive_regulation FOS MAP2K6 24116275 204254 Positive_regulation FOS MAP2K6 24820097 2968878 Positive_regulation FOS NEDD9 22427889 2610578 Positive_regulation FOS TCN1 24735601 1667970 Positive_regulation FOS TCN1 24735601 1667984 Positive_regulation FOS TCN1 24735601 1668001 Positive_regulation FOS TNF 19925655 327020 Positive_regulation FOS TNF 20504330 329095 Positive_regulation FOS TNF 23319874 841742 Positive_regulation FOS TNF 23674902 629804 Positive_regulation FOS TNF 24069158 2851338 Positive_regulation FOS TNF 24069158 2851488 Positive_regulation FOS TNF 24069158 2851603 Positive_regulation FOS TNF 24386331 2903535 Positive_regulation FOS TNF 24386331 2903657 Positive_regulation FOS TNF 24386331 2903658 Positive_regulation FOSB TNF 15142264 101172 Positive_regulation FOSL1 EPHB2 17254320 249965 Positive_regulation FOSL1 EPHB2 22438909 2612024 Positive_regulation FOSL1 EPHB2 25325755 1638184 Positive_regulation FOSL1 MMP28 17537262 2232614 Positive_regulation FOSL1 MMP7 17537262 2232629 Positive_regulation FOSL1 TNF PMC3007750 1702436 Positive_regulation FOSL2 EPHB2 10648566 1255391 Positive_regulation FOSL2 EPHB2 22438909 2612025 Positive_regulation FOSL2 EPHB2 23807221 563441 Positive_regulation FOSL2 TNF 15142264 101173 Positive_regulation FOXA1 CDH1 22590586 2642257 Positive_regulation FOXA1 CDH1 24512546 271512 Positive_regulation FOXA1 CREB1 23469012 2760634 Positive_regulation FOXA1 CTCF 22142239 334827 Positive_regulation FOXA1 EIF2AK4 23692540 32782 Positive_regulation FOXA1 ELF5 23534926 472933 Positive_regulation FOXA1 EPHB2 22817771 471874 Positive_regulation FOXA1 ERBB2 22391567 2146658 Positive_regulation FOXA1 ESR1 23845084 344174 Positive_regulation FOXA1 FOXA2 18973680 324321 Positive_regulation FOXA1 FOXA2 25081205 2103525 Positive_regulation FOXA1 FOXA3 24971943 2985130 Positive_regulation FOXA1 GATA3 23845084 344175 Positive_regulation FOXA1 GATA3 25364741 862391 Positive_regulation FOXA1 GATA3 25364741 862394 Positive_regulation FOXA1 GREB1 21878914 1904082 Positive_regulation FOXA1 HNF1A 24963715 2983457 Positive_regulation FOXA1 HNF4A 24122008 18556 Positive_regulation FOXA1 IGF1 23118920 2712153 Positive_regulation FOXA1 KDM4B 23723241 2088930 Positive_regulation FOXA1 KDM4B 23723241 2088950 Positive_regulation FOXA1 KDM4B 23723241 2088961 Positive_regulation FOXA1 KMT2A 24288367 2096298 Positive_regulation FOXA1 KMT2A 24288367 2096299 Positive_regulation FOXA1 KMT2A 24288367 2096300 Positive_regulation FOXA1 KMT2A 24288367 2096301 Positive_regulation FOXA1 KMT2A 24288367 2096305 Positive_regulation FOXA1 KMT2A 24288367 2096306 Positive_regulation FOXA1 KMT2A 24288367 2096308 Positive_regulation FOXA1 NFATC3 24964096 2983515 Positive_regulation FOXA1 NOTO 23383217 2749518 Positive_regulation FOXA1 SHH 22988464 3173591 Positive_regulation FOXA1 SHH 23383217 2749511 Positive_regulation FOXA1 SOX17 19479035 2417350 Positive_regulation FOXA1 TBX1 24039608 2349890 Positive_regulation FOXA1 TBX10 24039608 2349891 Positive_regulation FOXA1 TBX15 24039608 2349892 Positive_regulation FOXA1 TBX18 24039608 2349893 Positive_regulation FOXA1 TBX19 24039608 2349894 Positive_regulation FOXA1 TBX2 24039608 2349895 Positive_regulation FOXA1 TBX20 24039608 2349896 Positive_regulation FOXA1 TBX21 24039608 2349897 Positive_regulation FOXA1 TBX22 24039608 2349898 Positive_regulation FOXA1 TBX3 24039608 2349899 Positive_regulation FOXA1 TBX4 24039608 2349900 Positive_regulation FOXA1 TBX5 24039608 2349901 Positive_regulation FOXA1 TBX6 24039608 2349902 Positive_regulation FOXA1 TP53 22383394 2179740 Positive_regulation FOXA1 UCP1 22238690 2587077 Positive_regulation FOXA1 XBP1 23845084 344173 Positive_regulation FOXA1 ZNF217 24962896 347812 Positive_regulation FOXA2 FOXA1 24963715 2983459 Positive_regulation FOXA2 FOXO1 18523562 2389972 Positive_regulation FOXA2 FOXO1 23372643 2745596 Positive_regulation FOXC1 PODXL 25485314 579622 Positive_regulation FOXC2 EPHB2 23815774 380264 Positive_regulation FOXD3 MSX1 23284303 2340843 Positive_regulation FOXD3 MSX1 23284303 2340844 Positive_regulation FOXK1 TNF 18472820 1741847 Positive_regulation FOXM1 EPHB2 21858223 2546974 Positive_regulation FOXM1 EPHB2 21858223 2546980 Positive_regulation FOXM1 EPHB2 21858223 2546984 Positive_regulation FOXM1 MAP2K6 23240008 2727363 Positive_regulation FOXM1 MAP2K6 23386997 942136 Positive_regulation FOXM1 TNF 25101278 195811 Positive_regulation FOXN1 KRT38 22808421 3131006 Positive_regulation FOXO1 ABL1 21911423 1565291 Positive_regulation FOXO1 ABL1 23935640 3174131 Positive_regulation FOXO1 ABL1 24806995 3172232 Positive_regulation FOXO1 ACTR2 24039594 2349696 Positive_regulation FOXO1 ACTR3 24039594 2349697 Positive_regulation FOXO1 AGRP 24798184 3141733 Positive_regulation FOXO1 AHSA1 20716932 2222695 Positive_regulation FOXO1 AKT1 12844367 298065 Positive_regulation FOXO1 AKT1 14668045 830415 Positive_regulation FOXO1 AKT1 17997602 3040236 Positive_regulation FOXO1 AKT1 18000534 2380566 Positive_regulation FOXO1 AKT1 18355401 1646208 Positive_regulation FOXO1 AKT1 18443203 705777 Positive_regulation FOXO1 AKT1 18620552 1163636 Positive_regulation FOXO1 AKT1 19108710 324545 Positive_regulation FOXO1 AKT1 19365547 2412820 Positive_regulation FOXO1 AKT1 19808258 1556492 Positive_regulation FOXO1 AKT1 20007934 712120 Positive_regulation FOXO1 AKT1 20007934 712149 Positive_regulation FOXO1 AKT1 20139898 8974 Positive_regulation FOXO1 AKT1 20139898 8975 Positive_regulation FOXO1 AKT1 20139898 8983 Positive_regulation FOXO1 AKT1 20567500 2453166 Positive_regulation FOXO1 AKT1 20567500 2453183 Positive_regulation FOXO1 AKT1 20642839 1647323 Positive_regulation FOXO1 AKT1 20657036 27574 Positive_regulation FOXO1 AKT1 20657733 2456382 Positive_regulation FOXO1 AKT1 21144036 1647953 Positive_regulation FOXO1 AKT1 21179458 2488117 Positive_regulation FOXO1 AKT1 21209957 2492632 Positive_regulation FOXO1 AKT1 21209957 2492644 Positive_regulation FOXO1 AKT1 21266327 717107 Positive_regulation FOXO1 AKT1 21266327 717132 Positive_regulation FOXO1 AKT1 21317453 2175267 Positive_regulation FOXO1 AKT1 21335550 1190769 Positive_regulation FOXO1 AKT1 21537415 730258 Positive_regulation FOXO1 AKT1 21699736 2112843 Positive_regulation FOXO1 AKT1 21798082 3160100 Positive_regulation FOXO1 AKT1 21911423 1565288 Positive_regulation FOXO1 AKT1 21957439 2557176 Positive_regulation FOXO1 AKT1 21966641 1238447 Positive_regulation FOXO1 AKT1 22102829 2327667 Positive_regulation FOXO1 AKT1 22312004 1395031 Positive_regulation FOXO1 AKT1 22363451 2599149 Positive_regulation FOXO1 AKT1 22363451 2599169 Positive_regulation FOXO1 AKT1 22400069 2608788 Positive_regulation FOXO1 AKT1 22400069 2608792 Positive_regulation FOXO1 AKT1 22412893 2609564 Positive_regulation FOXO1 AKT1 22477519 1238915 Positive_regulation FOXO1 AKT1 22621320 150569 Positive_regulation FOXO1 AKT1 22649777 939913 Positive_regulation FOXO1 AKT1 22666216 876680 Positive_regulation FOXO1 AKT1 22848439 2669021 Positive_regulation FOXO1 AKT1 22870349 696151 Positive_regulation FOXO1 AKT1 22876196 2337389 Positive_regulation FOXO1 AKT1 22891897 2113409 Positive_regulation FOXO1 AKT1 23091640 2705843 Positive_regulation FOXO1 AKT1 23202496 3221810 Positive_regulation FOXO1 AKT1 23268536 740198 Positive_regulation FOXO1 AKT1 23382542 1570779 Positive_regulation FOXO1 AKT1 23392169 559404 Positive_regulation FOXO1 AKT1 23499576 3204108 Positive_regulation FOXO1 AKT1 23638435 943379 Positive_regulation FOXO1 AKT1 23644504 1958902 Positive_regulation FOXO1 AKT1 23661003 561750 Positive_regulation FOXO1 AKT1 23706767 625734 Positive_regulation FOXO1 AKT1 23786484 32934 Positive_regulation FOXO1 AKT1 23786484 33094 Positive_regulation FOXO1 AKT1 23786484 33095 Positive_regulation FOXO1 AKT1 23835113 1726171 Positive_regulation FOXO1 AKT1 23878308 1572766 Positive_regulation FOXO1 AKT1 23878308 1572857 Positive_regulation FOXO1 AKT1 23887651 1109347 Positive_regulation FOXO1 AKT1 23906066 700815 Positive_regulation FOXO1 AKT1 23940660 2831956 Positive_regulation FOXO1 AKT1 23995784 2153336 Positive_regulation FOXO1 AKT1 23995784 2153337 Positive_regulation FOXO1 AKT1 23995784 2153392 Positive_regulation FOXO1 AKT1 24041262 510230 Positive_regulation FOXO1 AKT1 24077633 18517 Positive_regulation FOXO1 AKT1 24116102 2865416 Positive_regulation FOXO1 AKT1 24159000 728729 Positive_regulation FOXO1 AKT1 24238363 221953 Positive_regulation FOXO1 AKT1 24240319 1964746 Positive_regulation FOXO1 AKT1 24260486 2884618 Positive_regulation FOXO1 AKT1 24376685 2901805 Positive_regulation FOXO1 AKT1 24457952 571268 Positive_regulation FOXO1 AKT1 24527269 3188086 Positive_regulation FOXO1 AKT1 24550841 964125 Positive_regulation FOXO1 AKT1 24575365 20609 Positive_regulation FOXO1 AKT1 24765092 912300 Positive_regulation FOXO1 AKT1 24806995 3172256 Positive_regulation FOXO1 AKT1 24843827 589696 Positive_regulation FOXO1 AKT1 24843827 589712 Positive_regulation FOXO1 AKT1 24864265 191784 Positive_regulation FOXO1 AKT1 24876677 1758992 Positive_regulation FOXO1 AKT1 24944899 1888143 Positive_regulation FOXO1 AKT1 24948874 1063050 Positive_regulation FOXO1 AKT1 24964141 2983521 Positive_regulation FOXO1 AKT1 25061609 195529 Positive_regulation FOXO1 AKT1 25140191 2114070 Positive_regulation FOXO1 AKT1 25152703 694657 Positive_regulation FOXO1 AKT1 25157276 1240801 Positive_regulation FOXO1 AKT1 25162582 3002790 Positive_regulation FOXO1 AKT1 25162582 3002899 Positive_regulation FOXO1 AKT1 25250333 200030 Positive_regulation FOXO1 AKT1 25329475 3016141 Positive_regulation FOXO1 AKT1 25512691 3216609 Positive_regulation FOXO1 AKT1 25530976 1496818 Positive_regulation FOXO1 AKT1 25610711 478662 Positive_regulation FOXO1 AKT2 12844367 298066 Positive_regulation FOXO1 AKT2 14668045 830416 Positive_regulation FOXO1 AKT2 17997602 3040237 Positive_regulation FOXO1 AKT2 18000534 2380567 Positive_regulation FOXO1 AKT2 18355401 1646209 Positive_regulation FOXO1 AKT2 18443203 705778 Positive_regulation FOXO1 AKT2 19108710 324546 Positive_regulation FOXO1 AKT2 19365547 2412821 Positive_regulation FOXO1 AKT2 20007934 712121 Positive_regulation FOXO1 AKT2 20007934 712150 Positive_regulation FOXO1 AKT2 20139898 8976 Positive_regulation FOXO1 AKT2 20139898 8977 Positive_regulation FOXO1 AKT2 20139898 8984 Positive_regulation FOXO1 AKT2 20567500 2453167 Positive_regulation FOXO1 AKT2 20567500 2453184 Positive_regulation FOXO1 AKT2 20642839 1647324 Positive_regulation FOXO1 AKT2 20657036 27575 Positive_regulation FOXO1 AKT2 20657733 2456383 Positive_regulation FOXO1 AKT2 21144036 1647954 Positive_regulation FOXO1 AKT2 21179458 2488118 Positive_regulation FOXO1 AKT2 21209957 2492633 Positive_regulation FOXO1 AKT2 21209957 2492645 Positive_regulation FOXO1 AKT2 21266327 717108 Positive_regulation FOXO1 AKT2 21266327 717133 Positive_regulation FOXO1 AKT2 21317453 2175268 Positive_regulation FOXO1 AKT2 21335550 1190770 Positive_regulation FOXO1 AKT2 21460183 1789180 Positive_regulation FOXO1 AKT2 21460183 1789196 Positive_regulation FOXO1 AKT2 21537415 730259 Positive_regulation FOXO1 AKT2 21699736 2112844 Positive_regulation FOXO1 AKT2 21798082 3160101 Positive_regulation FOXO1 AKT2 21911423 1565289 Positive_regulation FOXO1 AKT2 21957439 2557177 Positive_regulation FOXO1 AKT2 21966641 1238448 Positive_regulation FOXO1 AKT2 22102829 2327668 Positive_regulation FOXO1 AKT2 22312004 1395032 Positive_regulation FOXO1 AKT2 22363451 2599150 Positive_regulation FOXO1 AKT2 22363451 2599170 Positive_regulation FOXO1 AKT2 22400069 2608789 Positive_regulation FOXO1 AKT2 22400069 2608793 Positive_regulation FOXO1 AKT2 22477519 1238916 Positive_regulation FOXO1 AKT2 22621320 150570 Positive_regulation FOXO1 AKT2 22649777 939914 Positive_regulation FOXO1 AKT2 22666216 876681 Positive_regulation FOXO1 AKT2 22848439 2669022 Positive_regulation FOXO1 AKT2 22870349 696152 Positive_regulation FOXO1 AKT2 22876196 2337390 Positive_regulation FOXO1 AKT2 22888331 903208 Positive_regulation FOXO1 AKT2 22888331 903230 Positive_regulation FOXO1 AKT2 22891897 2113410 Positive_regulation FOXO1 AKT2 23091640 2705844 Positive_regulation FOXO1 AKT2 23202496 3221811 Positive_regulation FOXO1 AKT2 23268536 740199 Positive_regulation FOXO1 AKT2 23382542 1570780 Positive_regulation FOXO1 AKT2 23392169 559405 Positive_regulation FOXO1 AKT2 23499576 3204109 Positive_regulation FOXO1 AKT2 23638435 943380 Positive_regulation FOXO1 AKT2 23644504 1958903 Positive_regulation FOXO1 AKT2 23661003 561751 Positive_regulation FOXO1 AKT2 23706767 625735 Positive_regulation FOXO1 AKT2 23786484 32935 Positive_regulation FOXO1 AKT2 23786484 33096 Positive_regulation FOXO1 AKT2 23786484 33097 Positive_regulation FOXO1 AKT2 23835113 1726172 Positive_regulation FOXO1 AKT2 23878308 1572767 Positive_regulation FOXO1 AKT2 23878308 1572858 Positive_regulation FOXO1 AKT2 23887651 1109348 Positive_regulation FOXO1 AKT2 23906066 700816 Positive_regulation FOXO1 AKT2 23940660 2831957 Positive_regulation FOXO1 AKT2 23995784 2153338 Positive_regulation FOXO1 AKT2 23995784 2153339 Positive_regulation FOXO1 AKT2 23995784 2153393 Positive_regulation FOXO1 AKT2 24041262 510231 Positive_regulation FOXO1 AKT2 24077633 18518 Positive_regulation FOXO1 AKT2 24116102 2865417 Positive_regulation FOXO1 AKT2 24159000 728730 Positive_regulation FOXO1 AKT2 24194850 2872514 Positive_regulation FOXO1 AKT2 24238363 221954 Positive_regulation FOXO1 AKT2 24240319 1964747 Positive_regulation FOXO1 AKT2 24260486 2884619 Positive_regulation FOXO1 AKT2 24376685 2901806 Positive_regulation FOXO1 AKT2 24457952 571269 Positive_regulation FOXO1 AKT2 24527269 3188087 Positive_regulation FOXO1 AKT2 24550841 964126 Positive_regulation FOXO1 AKT2 24575365 20610 Positive_regulation FOXO1 AKT2 24765092 912301 Positive_regulation FOXO1 AKT2 24806995 3172257 Positive_regulation FOXO1 AKT2 24843827 589697 Positive_regulation FOXO1 AKT2 24843827 589713 Positive_regulation FOXO1 AKT2 24864265 191785 Positive_regulation FOXO1 AKT2 24876677 1758993 Positive_regulation FOXO1 AKT2 24944899 1888144 Positive_regulation FOXO1 AKT2 24948874 1063051 Positive_regulation FOXO1 AKT2 24964141 2983522 Positive_regulation FOXO1 AKT2 25061609 195530 Positive_regulation FOXO1 AKT2 25140191 2114071 Positive_regulation FOXO1 AKT2 25152703 694658 Positive_regulation FOXO1 AKT2 25162582 3002791 Positive_regulation FOXO1 AKT2 25162582 3002900 Positive_regulation FOXO1 AKT2 25250333 200031 Positive_regulation FOXO1 AKT2 25329475 3016142 Positive_regulation FOXO1 AKT2 25530976 1496819 Positive_regulation FOXO1 AKT2 25610711 478663 Positive_regulation FOXO1 AKT3 12844367 298067 Positive_regulation FOXO1 AKT3 14668045 830417 Positive_regulation FOXO1 AKT3 17997602 3040238 Positive_regulation FOXO1 AKT3 18000534 2380568 Positive_regulation FOXO1 AKT3 18355401 1646210 Positive_regulation FOXO1 AKT3 18443203 705779 Positive_regulation FOXO1 AKT3 19108710 324547 Positive_regulation FOXO1 AKT3 19365547 2412822 Positive_regulation FOXO1 AKT3 20007934 712122 Positive_regulation FOXO1 AKT3 20007934 712151 Positive_regulation FOXO1 AKT3 20139898 8978 Positive_regulation FOXO1 AKT3 20139898 8979 Positive_regulation FOXO1 AKT3 20139898 8985 Positive_regulation FOXO1 AKT3 20567500 2453168 Positive_regulation FOXO1 AKT3 20567500 2453185 Positive_regulation FOXO1 AKT3 20642839 1647325 Positive_regulation FOXO1 AKT3 20657036 27576 Positive_regulation FOXO1 AKT3 20657733 2456384 Positive_regulation FOXO1 AKT3 21144036 1647955 Positive_regulation FOXO1 AKT3 21179458 2488119 Positive_regulation FOXO1 AKT3 21209957 2492634 Positive_regulation FOXO1 AKT3 21209957 2492646 Positive_regulation FOXO1 AKT3 21266327 717109 Positive_regulation FOXO1 AKT3 21266327 717134 Positive_regulation FOXO1 AKT3 21317453 2175269 Positive_regulation FOXO1 AKT3 21335550 1190771 Positive_regulation FOXO1 AKT3 21460183 1789181 Positive_regulation FOXO1 AKT3 21537415 730260 Positive_regulation FOXO1 AKT3 21699736 2112845 Positive_regulation FOXO1 AKT3 21798082 3160102 Positive_regulation FOXO1 AKT3 21911423 1565290 Positive_regulation FOXO1 AKT3 21957439 2557178 Positive_regulation FOXO1 AKT3 21966641 1238449 Positive_regulation FOXO1 AKT3 22102829 2327669 Positive_regulation FOXO1 AKT3 22312004 1395033 Positive_regulation FOXO1 AKT3 22363451 2599151 Positive_regulation FOXO1 AKT3 22363451 2599171 Positive_regulation FOXO1 AKT3 22400069 2608790 Positive_regulation FOXO1 AKT3 22400069 2608794 Positive_regulation FOXO1 AKT3 22477519 1238917 Positive_regulation FOXO1 AKT3 22621320 150571 Positive_regulation FOXO1 AKT3 22649777 939915 Positive_regulation FOXO1 AKT3 22666216 876682 Positive_regulation FOXO1 AKT3 22848439 2669023 Positive_regulation FOXO1 AKT3 22870349 696153 Positive_regulation FOXO1 AKT3 22876196 2337391 Positive_regulation FOXO1 AKT3 22891897 2113411 Positive_regulation FOXO1 AKT3 23091640 2705845 Positive_regulation FOXO1 AKT3 23202496 3221812 Positive_regulation FOXO1 AKT3 23268536 740200 Positive_regulation FOXO1 AKT3 23382542 1570781 Positive_regulation FOXO1 AKT3 23392169 559406 Positive_regulation FOXO1 AKT3 23499576 3204110 Positive_regulation FOXO1 AKT3 23638435 943381 Positive_regulation FOXO1 AKT3 23644504 1958904 Positive_regulation FOXO1 AKT3 23661003 561752 Positive_regulation FOXO1 AKT3 23706767 625736 Positive_regulation FOXO1 AKT3 23786484 32936 Positive_regulation FOXO1 AKT3 23786484 33098 Positive_regulation FOXO1 AKT3 23786484 33099 Positive_regulation FOXO1 AKT3 23835113 1726173 Positive_regulation FOXO1 AKT3 23878308 1572768 Positive_regulation FOXO1 AKT3 23878308 1572859 Positive_regulation FOXO1 AKT3 23887651 1109349 Positive_regulation FOXO1 AKT3 23906066 700817 Positive_regulation FOXO1 AKT3 23940660 2831958 Positive_regulation FOXO1 AKT3 23995784 2153340 Positive_regulation FOXO1 AKT3 23995784 2153341 Positive_regulation FOXO1 AKT3 23995784 2153394 Positive_regulation FOXO1 AKT3 24041262 510232 Positive_regulation FOXO1 AKT3 24077633 18519 Positive_regulation FOXO1 AKT3 24116102 2865418 Positive_regulation FOXO1 AKT3 24159000 728731 Positive_regulation FOXO1 AKT3 24238363 221955 Positive_regulation FOXO1 AKT3 24240319 1964748 Positive_regulation FOXO1 AKT3 24260486 2884620 Positive_regulation FOXO1 AKT3 24376685 2901807 Positive_regulation FOXO1 AKT3 24457952 571270 Positive_regulation FOXO1 AKT3 24527269 3188088 Positive_regulation FOXO1 AKT3 24550841 964127 Positive_regulation FOXO1 AKT3 24575365 20611 Positive_regulation FOXO1 AKT3 24765092 912302 Positive_regulation FOXO1 AKT3 24806995 3172258 Positive_regulation FOXO1 AKT3 24843827 589698 Positive_regulation FOXO1 AKT3 24843827 589714 Positive_regulation FOXO1 AKT3 24864265 191786 Positive_regulation FOXO1 AKT3 24876677 1758994 Positive_regulation FOXO1 AKT3 24944899 1888145 Positive_regulation FOXO1 AKT3 24948874 1063052 Positive_regulation FOXO1 AKT3 24964141 2983523 Positive_regulation FOXO1 AKT3 25061609 195531 Positive_regulation FOXO1 AKT3 25140191 2114072 Positive_regulation FOXO1 AKT3 25152703 694659 Positive_regulation FOXO1 AKT3 25162582 3002792 Positive_regulation FOXO1 AKT3 25162582 3002901 Positive_regulation FOXO1 AKT3 25250333 200032 Positive_regulation FOXO1 AKT3 25329475 3016143 Positive_regulation FOXO1 AKT3 25530976 1496820 Positive_regulation FOXO1 AKT3 25610711 478664 Positive_regulation FOXO1 ANGPT1 20805979 2471624 Positive_regulation FOXO1 ANGPT1 20805979 2471630 Positive_regulation FOXO1 ANGPT2 18355401 1646230 Positive_regulation FOXO1 ANGPT2 18355401 1646242 Positive_regulation FOXO1 ANGPT2 19435476 659215 Positive_regulation FOXO1 ANGPTL2 23781214 878784 Positive_regulation FOXO1 ANPEP 24836538 2971280 Positive_regulation FOXO1 ANPEP 24836538 2971289 Positive_regulation FOXO1 ANPEP 24836538 2971293 Positive_regulation FOXO1 ANPEP 24836538 2971297 Positive_regulation FOXO1 ANPEP 24836538 2971299 Positive_regulation FOXO1 ANPEP 24836538 2971300 Positive_regulation FOXO1 ANPEP 24836538 2971303 Positive_regulation FOXO1 ANPEP 24836538 2971304 Positive_regulation FOXO1 ANPEP 24836538 2971305 Positive_regulation FOXO1 APC 22675309 957660 Positive_regulation FOXO1 APPL1 22666216 876676 Positive_regulation FOXO1 APPL1 22666216 876679 Positive_regulation FOXO1 ARHGEF7 19651810 710747 Positive_regulation FOXO1 ARHGEF7 19651810 710757 Positive_regulation FOXO1 ARPC1B 24039594 2349698 Positive_regulation FOXO1 ARPC2 24039594 2349699 Positive_regulation FOXO1 ARPC3 24039594 2349700 Positive_regulation FOXO1 ARPC4 24039594 2349701 Positive_regulation FOXO1 ARPC5 24039594 2349702 Positive_regulation FOXO1 ATF4 25517766 1018952 Positive_regulation FOXO1 ATP7B 22312004 1395093 Positive_regulation FOXO1 BAX 17081294 1845825 Positive_regulation FOXO1 BCR 17208518 3203978 Positive_regulation FOXO1 BCR 21911423 1565287 Positive_regulation FOXO1 BCR 23935640 3174130 Positive_regulation FOXO1 BCR 24806995 3172229 Positive_regulation FOXO1 BPNT1 20028942 712400 Positive_regulation FOXO1 CA2 25088745 1943824 Positive_regulation FOXO1 CASP9 23610600 2115288 Positive_regulation FOXO1 CCDC88A 25043713 1943634 Positive_regulation FOXO1 CCL25 20565782 1676885 Positive_regulation FOXO1 CCL25 20565782 1676892 Positive_regulation FOXO1 CCL25 20565782 1676904 Positive_regulation FOXO1 CCL25 20565782 1676908 Positive_regulation FOXO1 CCL25 20565782 1676914 Positive_regulation FOXO1 CCL25 21539750 3226271 Positive_regulation FOXO1 CCL25 21539750 3226273 Positive_regulation FOXO1 CCND1 23469153 2762484 Positive_regulation FOXO1 CCND2 24416423 2908959 Positive_regulation FOXO1 CCNT1 21423649 2275328 Positive_regulation FOXO1 CCR9 20565782 1676886 Positive_regulation FOXO1 CCR9 20565782 1676893 Positive_regulation FOXO1 CCR9 21539750 3226274 Positive_regulation FOXO1 CD28 19363483 1952349 Positive_regulation FOXO1 CD36 23130316 730562 Positive_regulation FOXO1 CD36 25045276 645411 Positive_regulation FOXO1 CD55 17447841 3039583 Positive_regulation FOXO1 CD55 19749979 2310921 Positive_regulation FOXO1 CD55 20824162 2272307 Positive_regulation FOXO1 CD55 20975207 28363 Positive_regulation FOXO1 CD55 21909281 2326127 Positive_regulation FOXO1 CD55 23049887 2699775 Positive_regulation FOXO1 CD55 23284299 2340786 Positive_regulation FOXO1 CD55 23300463 2340965 Positive_regulation FOXO1 CD55 24385923 2354745 Positive_regulation FOXO1 CD79A 24806995 3172230 Positive_regulation FOXO1 CD79B 24806995 3172231 Positive_regulation FOXO1 CDK2 23995784 2153331 Positive_regulation FOXO1 CDK2 23995784 2153332 Positive_regulation FOXO1 CDK2 23995784 2153333 Positive_regulation FOXO1 CDK4 23469153 2762485 Positive_regulation FOXO1 CDK4 23469153 2762486 Positive_regulation FOXO1 CDK4 23469153 2762487 Positive_regulation FOXO1 CDK4 23469153 2762492 Positive_regulation FOXO1 CDK4 23469153 2762504 Positive_regulation FOXO1 CDK4 23469153 2762512 Positive_regulation FOXO1 CDK4 23469153 2762514 Positive_regulation FOXO1 CDK4 23469153 2762516 Positive_regulation FOXO1 CDK9 21423649 2275329 Positive_regulation FOXO1 CDKN1A 18312651 462678 Positive_regulation FOXO1 CDKN1B 18312651 462679 Positive_regulation FOXO1 CHUK 20567500 2453205 Positive_regulation FOXO1 CHUK 22570785 1688281 Positive_regulation FOXO1 CHUK 22649777 939911 Positive_regulation FOXO1 CHUK 23035900 1231290 Positive_regulation FOXO1 CPT1A 22533991 264537 Positive_regulation FOXO1 CREB1 24379407 1208853 Positive_regulation FOXO1 CREB1 24379407 1208860 Positive_regulation FOXO1 CREB3 24379407 1208854 Positive_regulation FOXO1 CREB3 24379407 1208861 Positive_regulation FOXO1 CREB5 24379407 1208852 Positive_regulation FOXO1 CREB5 24379407 1208859 Positive_regulation FOXO1 CTLA4 15492127 1533757 Positive_regulation FOXO1 CTLA4 15492127 1533798 Positive_regulation FOXO1 DUSP6 22848439 2669008 Positive_regulation FOXO1 DUSP6 22848439 2669019 Positive_regulation FOXO1 E2F1 20405009 2446626 Positive_regulation FOXO1 ECI1 22997544 2224963 Positive_regulation FOXO1 EDN1 24745009 189168 Positive_regulation FOXO1 EGF 18000534 2380609 Positive_regulation FOXO1 EGF 18355401 1646229 Positive_regulation FOXO1 EGFR 22242005 2328359 Positive_regulation FOXO1 EIF2AK2 20685959 1779529 Positive_regulation FOXO1 EIF2AK2 23202496 3221813 Positive_regulation FOXO1 ELAVL1 23946796 2165361 Positive_regulation FOXO1 ELAVL1 23946796 2165362 Positive_regulation FOXO1 ELAVL1 23946796 2165363 Positive_regulation FOXO1 ELAVL1 23946796 2165364 Positive_regulation FOXO1 ELAVL1 23946796 2165365 Positive_regulation FOXO1 ELAVL1 23946796 2165370 Positive_regulation FOXO1 ELAVL1 23946796 2165372 Positive_regulation FOXO1 ELAVL1 23946796 2165375 Positive_regulation FOXO1 ELAVL1 23946796 2165376 Positive_regulation FOXO1 ELAVL1 23946796 2165380 Positive_regulation FOXO1 EPHB2 21980390 2560211 Positive_regulation FOXO1 EPHB2 22242005 2328360 Positive_regulation FOXO1 EPHB2 22649777 939912 Positive_regulation FOXO1 EPHB2 23277279 610844 Positive_regulation FOXO1 EPHB2 23277279 610909 Positive_regulation FOXO1 ESR1 25321482 578469 Positive_regulation FOXO1 FABP1 22997544 2224965 Positive_regulation FOXO1 FABP12 22997544 2224964 Positive_regulation FOXO1 FABP2 22997544 2224966 Positive_regulation FOXO1 FABP3 22997544 2224967 Positive_regulation FOXO1 FABP4 22997544 2224968 Positive_regulation FOXO1 FABP5 22997544 2224969 Positive_regulation FOXO1 FABP6 22997544 2224970 Positive_regulation FOXO1 FABP7 22997544 2224971 Positive_regulation FOXO1 FABP9 22997544 2224972 Positive_regulation FOXO1 FAM65B 25330112 3017205 Positive_regulation FOXO1 FBXO32 18047744 226233 Positive_regulation FOXO1 FBXO32 25294954 1762718 Positive_regulation FOXO1 FBXO32 25625009 3163485 Positive_regulation FOXO1 FLI1 23995784 2153334 Positive_regulation FOXO1 FLI1 23995784 2153335 Positive_regulation FOXO1 FLI1 23995784 2153364 Positive_regulation FOXO1 FLI1 23995784 2153365 Positive_regulation FOXO1 FLI1 23995784 2153376 Positive_regulation FOXO1 FLI1 23995784 2153382 Positive_regulation FOXO1 FLI1 23995784 2153383 Positive_regulation FOXO1 FLI1 23995784 2153391 Positive_regulation FOXO1 FOXA2 18523562 2389971 Positive_regulation FOXO1 FOXL2 25423188 3030086 Positive_regulation FOXO1 FOXO1 20642839 1647356 Positive_regulation FOXO1 FOXO1 21179458 2488010 Positive_regulation FOXO1 FOXO1 21980390 2560212 Positive_regulation FOXO1 FOXO1 22555369 14817 Positive_regulation FOXO1 FOXO1 23555761 2775260 Positive_regulation FOXO1 FOXO1 23800068 830114 Positive_regulation FOXO1 FOXO1 25136826 2998913 Positive_regulation FOXO1 FOXO3 20642839 1647357 Positive_regulation FOXO1 FOXO3 21179458 2488011 Positive_regulation FOXO1 FOXO3 21179458 2488012 Positive_regulation FOXO1 FOXO3 21179458 2488076 Positive_regulation FOXO1 FOXO3 21980390 2560213 Positive_regulation FOXO1 FOXO3 22555369 14818 Positive_regulation FOXO1 FOXO3 22848740 2670317 Positive_regulation FOXO1 FOXO3 23800068 830253 Positive_regulation FOXO1 FOXO3 24265696 2884924 Positive_regulation FOXO1 FOXO3 24265696 2884925 Positive_regulation FOXO1 FOXO3 25546383 3036505 Positive_regulation FOXO1 FOXO4 20642839 1647358 Positive_regulation FOXO1 FOXO4 21179458 2488013 Positive_regulation FOXO1 FOXO4 21980390 2560214 Positive_regulation FOXO1 FOXO4 22555369 14819 Positive_regulation FOXO1 FOXO6 22555369 14816 Positive_regulation FOXO1 FOXP3 20439537 1558153 Positive_regulation FOXO1 FOXP3 23878131 477838 Positive_regulation FOXO1 FXR1 22577560 1639171 Positive_regulation FOXO1 FXR2 22577560 1639172 Positive_regulation FOXO1 G6PC 21304897 2500033 Positive_regulation FOXO1 GADD45A 25400915 1036983 Positive_regulation FOXO1 GCG 22934027 958494 Positive_regulation FOXO1 GCG 24379407 1208825 Positive_regulation FOXO1 GCG 24379407 1208849 Positive_regulation FOXO1 GCG 24379407 1208855 Positive_regulation FOXO1 GRAP2 20300563 1910588 Positive_regulation FOXO1 GRAP2 20716932 2222693 Positive_regulation FOXO1 GRAP2 24159000 728764 Positive_regulation FOXO1 GSK3B 24931005 2192482 Positive_regulation FOXO1 HCFC1 18828672 2265089 Positive_regulation FOXO1 HCFC1 21909281 2326075 Positive_regulation FOXO1 HCFC2 21909281 2326074 Positive_regulation FOXO1 HDAC1 25329053 2365584 Positive_regulation FOXO1 HDAC4 22662228 2647533 Positive_regulation FOXO1 HGF 22081023 1961787 Positive_regulation FOXO1 HMOX1 21699736 2112838 Positive_regulation FOXO1 HMOX1 22454632 832695 Positive_regulation FOXO1 HMOX1 22454632 832738 Positive_regulation FOXO1 HMOX1 24115839 742825 Positive_regulation FOXO1 HMOX1 24224047 2877994 Positive_regulation FOXO1 HMOX1 24255720 2882042 Positive_regulation FOXO1 HOXA10 15200677 3095788 Positive_regulation FOXO1 HSF1 20007934 712123 Positive_regulation FOXO1 HSP90B1 25369332 3022708 Positive_regulation FOXO1 IFI27 24112473 270047 Positive_regulation FOXO1 IGF1 14668045 830418 Positive_regulation FOXO1 IGF1 21990145 29905 Positive_regulation FOXO1 IGF1 21991327 2561459 Positive_regulation FOXO1 IGF1 22621320 150572 Positive_regulation FOXO1 IGF1 22870349 696154 Positive_regulation FOXO1 IGF1 23614736 830048 Positive_regulation FOXO1 IGF1 23906066 700767 Positive_regulation FOXO1 IGF1 24069505 2226967 Positive_regulation FOXO1 IGF1 24244197 2352904 Positive_regulation FOXO1 IGF1 24968248 3068287 Positive_regulation FOXO1 IGF1 24968248 3068299 Positive_regulation FOXO1 IGF1R 23906066 700832 Positive_regulation FOXO1 IGF2 23906066 700768 Positive_regulation FOXO1 IGFBP1 23614736 830014 Positive_regulation FOXO1 IKBKB 20567500 2453206 Positive_regulation FOXO1 IKBKB 22570785 1688282 Positive_regulation FOXO1 IKBKB 22649777 939916 Positive_regulation FOXO1 IKBKB 23035900 1231291 Positive_regulation FOXO1 IKBKG 20567500 2453207 Positive_regulation FOXO1 IKBKG 22570785 1688283 Positive_regulation FOXO1 IKBKG 22649777 939917 Positive_regulation FOXO1 IKBKG 23035900 1231292 Positive_regulation FOXO1 IL1A 22084407 1566027 Positive_regulation FOXO1 IL2 22532866 2621809 Positive_regulation FOXO1 IL7 15353558 1533343 Positive_regulation FOXO1 IL7 15353558 1533409 Positive_regulation FOXO1 IL7 22363451 2599117 Positive_regulation FOXO1 IL7 22363451 2599156 Positive_regulation FOXO1 IL7 22363451 2599181 Positive_regulation FOXO1 IL7 24765092 912303 Positive_regulation FOXO1 INS 12908874 1162990 Positive_regulation FOXO1 INS 12967350 3095102 Positive_regulation FOXO1 INS 12974982 1163019 Positive_regulation FOXO1 INS 17531095 2013438 Positive_regulation FOXO1 INS 18299344 1349443 Positive_regulation FOXO1 INS 19651810 710732 Positive_regulation FOXO1 INS 19651810 710738 Positive_regulation FOXO1 INS 19651810 710770 Positive_regulation FOXO1 INS 19727444 2425695 Positive_regulation FOXO1 INS 19755527 711120 Positive_regulation FOXO1 INS 19769782 659339 Positive_regulation FOXO1 INS 20028942 712374 Positive_regulation FOXO1 INS 20028942 712375 Positive_regulation FOXO1 INS 20028942 712386 Positive_regulation FOXO1 INS 20028942 712406 Positive_regulation FOXO1 INS 20028942 712407 Positive_regulation FOXO1 INS 20028942 712420 Positive_regulation FOXO1 INS 20103705 712850 Positive_regulation FOXO1 INS 20185816 712942 Positive_regulation FOXO1 INS 20216949 1489791 Positive_regulation FOXO1 INS 20216949 1489792 Positive_regulation FOXO1 INS 20216949 1489873 Positive_regulation FOXO1 INS 20299475 713288 Positive_regulation FOXO1 INS 20567500 2453186 Positive_regulation FOXO1 INS 20664791 3048189 Positive_regulation FOXO1 INS 20664791 3048192 Positive_regulation FOXO1 INS 20851344 621786 Positive_regulation FOXO1 INS 21119640 1932304 Positive_regulation FOXO1 INS 21152033 2485819 Positive_regulation FOXO1 INS 21152033 2485828 Positive_regulation FOXO1 INS 21283589 2496908 Positive_regulation FOXO1 INS 21335550 1190784 Positive_regulation FOXO1 INS 21346174 717969 Positive_regulation FOXO1 INS 21346725 1709692 Positive_regulation FOXO1 INS 21464441 719013 Positive_regulation FOXO1 INS 21464441 719015 Positive_regulation FOXO1 INS 21980302 2326763 Positive_regulation FOXO1 INS 21990145 29906 Positive_regulation FOXO1 INS 22140505 2574834 Positive_regulation FOXO1 INS 22253608 2328811 Positive_regulation FOXO1 INS 22344295 1962146 Positive_regulation FOXO1 INS 22500143 3152555 Positive_regulation FOXO1 INS 22590537 2641133 Positive_regulation FOXO1 INS 22654825 876082 Positive_regulation FOXO1 INS 22688333 723160 Positive_regulation FOXO1 INS 22688333 723165 Positive_regulation FOXO1 INS 22815850 2666426 Positive_regulation FOXO1 INS 22815850 2666433 Positive_regulation FOXO1 INS 22870349 696155 Positive_regulation FOXO1 INS 22876196 2337392 Positive_regulation FOXO1 INS 22933111 724415 Positive_regulation FOXO1 INS 23056614 2702409 Positive_regulation FOXO1 INS 23110872 2113562 Positive_regulation FOXO1 INS 23349480 725604 Positive_regulation FOXO1 INS 23356701 89712 Positive_regulation FOXO1 INS 23356701 89719 Positive_regulation FOXO1 INS 23394097 692639 Positive_regulation FOXO1 INS 23397118 1606764 Positive_regulation FOXO1 INS 23442260 1036526 Positive_regulation FOXO1 INS 23493568 726900 Positive_regulation FOXO1 INS 23554788 1226235 Positive_regulation FOXO1 INS 23614736 829939 Positive_regulation FOXO1 INS 23614736 830049 Positive_regulation FOXO1 INS 23695665 1936696 Positive_regulation FOXO1 INS 23760991 2235660 Positive_regulation FOXO1 INS 23835343 727925 Positive_regulation FOXO1 INS 23878722 749569 Positive_regulation FOXO1 INS 23906066 700769 Positive_regulation FOXO1 INS 24069505 2226968 Positive_regulation FOXO1 INS 24159000 728688 Positive_regulation FOXO1 INS 24159000 728689 Positive_regulation FOXO1 INS 24159000 728759 Positive_regulation FOXO1 INS 24159000 728765 Positive_regulation FOXO1 INS 24244197 2352905 Positive_regulation FOXO1 INS 24489697 2916065 Positive_regulation FOXO1 INS 24490110 3151518 Positive_regulation FOXO1 INS 24551104 2923033 Positive_regulation FOXO1 INS 24551104 2923034 Positive_regulation FOXO1 INS 24551104 2923059 Positive_regulation FOXO1 INS 24843827 589718 Positive_regulation FOXO1 INS 24843827 589768 Positive_regulation FOXO1 INS 24949430 192604 Positive_regulation FOXO1 INS 24968248 3068300 Positive_regulation FOXO1 INS 25061609 195532 Positive_regulation FOXO1 INS 25136826 2998910 Positive_regulation FOXO1 INS 25136826 2998924 Positive_regulation FOXO1 INS 25143800 2229922 Positive_regulation FOXO1 INS 25299696 1131859 Positive_regulation FOXO1 INS 25343030 848190 Positive_regulation FOXO1 INS 25423188 3030107 Positive_regulation FOXO1 INSR 19767734 1960801 Positive_regulation FOXO1 INSR 23878722 749554 Positive_regulation FOXO1 INSR 24586650 2925836 Positive_regulation FOXO1 INSR 25426412 854301 Positive_regulation FOXO1 IRS1 20028942 712434 Positive_regulation FOXO1 IRS1 21991327 2561417 Positive_regulation FOXO1 IRS1 21991327 2561418 Positive_regulation FOXO1 IRS1 24159000 728690 Positive_regulation FOXO1 IRS1 24159000 728718 Positive_regulation FOXO1 IRS2 20028942 712435 Positive_regulation FOXO1 IRS2 23614736 830050 Positive_regulation FOXO1 IRS2 24159000 728691 Positive_regulation FOXO1 IRS2 24159000 728719 Positive_regulation FOXO1 JUN 20844315 28288 Positive_regulation FOXO1 JUNB 20921137 1380137 Positive_regulation FOXO1 KL 21076180 28784 Positive_regulation FOXO1 KLF2 24155966 2871829 Positive_regulation FOXO1 KLF2 24162775 1959284 Positive_regulation FOXO1 KLF2 24996903 3124998 Positive_regulation FOXO1 KRIT1 20668652 2457225 Positive_regulation FOXO1 KRIT1 20668652 2457226 Positive_regulation FOXO1 KRIT1 20668652 2457227 Positive_regulation FOXO1 KRIT1 20668652 2457228 Positive_regulation FOXO1 KRIT1 20668652 2457229 Positive_regulation FOXO1 KRIT1 20668652 2457242 Positive_regulation FOXO1 KRIT1 20668652 2457246 Positive_regulation FOXO1 KRIT1 20668652 2457247 Positive_regulation FOXO1 KRIT1 20668652 2457248 Positive_regulation FOXO1 KSR1 22242005 2328478 Positive_regulation FOXO1 LATS2 24525530 1940649 Positive_regulation FOXO1 LATS2 24525530 1940657 Positive_regulation FOXO1 LEP 24675731 2946777 Positive_regulation FOXO1 LEP 24675731 2946781 Positive_regulation FOXO1 LEP 24944903 1888208 Positive_regulation FOXO1 LEP 25343030 848191 Positive_regulation FOXO1 LGALS4 23853709 749526 Positive_regulation FOXO1 LIG1 22715401 2652864 Positive_regulation FOXO1 LIG3 22715401 2652865 Positive_regulation FOXO1 LIG4 22715401 2652866 Positive_regulation FOXO1 LPL 24520982 2113985 Positive_regulation FOXO1 MAOA 21267416 2495409 Positive_regulation FOXO1 MAP3K4 25400915 1036984 Positive_regulation FOXO1 MAPK1 22242005 2328361 Positive_regulation FOXO1 MAPK1 22715401 2652867 Positive_regulation FOXO1 MAPK1 23071610 2703234 Positive_regulation FOXO1 MAPK1 23533577 2770593 Positive_regulation FOXO1 MAPK1 24551104 2923045 Positive_regulation FOXO1 MAPK10 22242005 2328362 Positive_regulation FOXO1 MAPK10 23071610 2703235 Positive_regulation FOXO1 MAPK10 23533577 2770594 Positive_regulation FOXO1 MAPK10 24551104 2923046 Positive_regulation FOXO1 MAPK11 22242005 2328363 Positive_regulation FOXO1 MAPK11 23071610 2703236 Positive_regulation FOXO1 MAPK11 23533577 2770595 Positive_regulation FOXO1 MAPK11 24551104 2923047 Positive_regulation FOXO1 MAPK12 22242005 2328364 Positive_regulation FOXO1 MAPK12 23071610 2703237 Positive_regulation FOXO1 MAPK12 23533577 2770596 Positive_regulation FOXO1 MAPK12 24551104 2923048 Positive_regulation FOXO1 MAPK13 22242005 2328365 Positive_regulation FOXO1 MAPK13 23071610 2703238 Positive_regulation FOXO1 MAPK13 23533577 2770597 Positive_regulation FOXO1 MAPK13 24551104 2923049 Positive_regulation FOXO1 MAPK14 22242005 2328366 Positive_regulation FOXO1 MAPK14 23071610 2703239 Positive_regulation FOXO1 MAPK14 23533577 2770598 Positive_regulation FOXO1 MAPK14 24551104 2923050 Positive_regulation FOXO1 MAPK15 22242005 2328358 Positive_regulation FOXO1 MAPK15 23071610 2703233 Positive_regulation FOXO1 MAPK15 23533577 2770592 Positive_regulation FOXO1 MAPK15 24551104 2923044 Positive_regulation FOXO1 MAPK3 22242005 2328367 Positive_regulation FOXO1 MAPK3 23071610 2703240 Positive_regulation FOXO1 MAPK3 23533577 2770599 Positive_regulation FOXO1 MAPK3 24551104 2923051 Positive_regulation FOXO1 MAPK4 22242005 2328368 Positive_regulation FOXO1 MAPK4 23071610 2703241 Positive_regulation FOXO1 MAPK4 23533577 2770600 Positive_regulation FOXO1 MAPK4 24551104 2923052 Positive_regulation FOXO1 MAPK6 22242005 2328369 Positive_regulation FOXO1 MAPK6 23071610 2703242 Positive_regulation FOXO1 MAPK6 23533577 2770601 Positive_regulation FOXO1 MAPK6 24551104 2923053 Positive_regulation FOXO1 MAPK7 22242005 2328370 Positive_regulation FOXO1 MAPK7 23071610 2703243 Positive_regulation FOXO1 MAPK7 23533577 2770602 Positive_regulation FOXO1 MAPK7 24551104 2923054 Positive_regulation FOXO1 MAPK8 22242005 2328371 Positive_regulation FOXO1 MAPK8 23071610 2703244 Positive_regulation FOXO1 MAPK8 23533577 2770603 Positive_regulation FOXO1 MAPK8 24551104 2923055 Positive_regulation FOXO1 MAPK9 22242005 2328372 Positive_regulation FOXO1 MAPK9 23071610 2703245 Positive_regulation FOXO1 MAPK9 23533577 2770604 Positive_regulation FOXO1 MAPK9 24551104 2923056 Positive_regulation FOXO1 MAPKAP1 19209957 2266032 Positive_regulation FOXO1 MAPKAP1 22891897 2113406 Positive_regulation FOXO1 MAPKAP1 23812589 1990641 Positive_regulation FOXO1 MAPKAPK5 23878308 1572769 Positive_regulation FOXO1 MAPKAPK5 23878308 1572876 Positive_regulation FOXO1 MBD2 25329053 2365605 Positive_regulation FOXO1 MDM2 18665269 2394176 Positive_regulation FOXO1 MDM2 18665269 2394227 Positive_regulation FOXO1 MECP2 25329053 2365585 Positive_regulation FOXO1 MED23 25223702 612820 Positive_regulation FOXO1 MED23 25223702 612821 Positive_regulation FOXO1 MLST8 19209957 2266033 Positive_regulation FOXO1 MLST8 22473959 1568004 Positive_regulation FOXO1 MLST8 22891897 2113407 Positive_regulation FOXO1 MLST8 23183047 1570017 Positive_regulation FOXO1 MLST8 23183047 1570212 Positive_regulation FOXO1 MLST8 23644504 1958900 Positive_regulation FOXO1 MLST8 23812589 1990642 Positive_regulation FOXO1 MLST8 24255720 2882067 Positive_regulation FOXO1 MLST8 24740015 2954375 Positive_regulation FOXO1 MLST8 24806995 3172268 Positive_regulation FOXO1 MMP14 25162582 3002902 Positive_regulation FOXO1 MSTN 19586544 325509 Positive_regulation FOXO1 MSTN 21966641 1238470 Positive_regulation FOXO1 MSTN 22621320 150640 Positive_regulation FOXO1 MSTN 25221510 859480 Positive_regulation FOXO1 MSTN 25399751 694300 Positive_regulation FOXO1 MTOR 19209957 2266036 Positive_regulation FOXO1 MTOR 22473959 1568006 Positive_regulation FOXO1 MTOR 22891897 2113412 Positive_regulation FOXO1 MTOR 23183047 1570019 Positive_regulation FOXO1 MTOR 23183047 1570214 Positive_regulation FOXO1 MTOR 23349709 2743003 Positive_regulation FOXO1 MTOR 23644504 1958905 Positive_regulation FOXO1 MTOR 23812589 1990645 Positive_regulation FOXO1 MTOR 24255720 2882069 Positive_regulation FOXO1 MTOR 24740015 2954377 Positive_regulation FOXO1 MTOR 24806995 3172270 Positive_regulation FOXO1 MYLIP 21203424 2490125 Positive_regulation FOXO1 MYLIP 21203465 2490501 Positive_regulation FOXO1 MYLIP 21824387 3160481 Positive_regulation FOXO1 MYLIP 21920043 260926 Positive_regulation FOXO1 MYLIP 22475820 1709015 Positive_regulation FOXO1 MYLIP 22911744 2676058 Positive_regulation FOXO1 MYLIP 22911744 2676062 Positive_regulation FOXO1 MYLIP 22911744 2676064 Positive_regulation FOXO1 MYLIP 23029264 2695765 Positive_regulation FOXO1 MYLIP 23029264 2695769 Positive_regulation FOXO1 MYLIP 23748164 31279 Positive_regulation FOXO1 MYLIP 23946815 2165419 Positive_regulation FOXO1 MYLIP 23951320 2834192 Positive_regulation FOXO1 MYLIP 23951320 2834193 Positive_regulation FOXO1 MYLIP 24009212 781945 Positive_regulation FOXO1 MYLIP 24009212 781948 Positive_regulation FOXO1 MYLIP 24260486 2884612 Positive_regulation FOXO1 MYLIP 24260486 2884617 Positive_regulation FOXO1 MYLIP 24900964 192393 Positive_regulation FOXO1 MYLIP 25394902 476020 Positive_regulation FOXO1 NANOG 25369332 3022710 Positive_regulation FOXO1 NAV1 22400069 2608786 Positive_regulation FOXO1 NFATC1 21148296 1784455 Positive_regulation FOXO1 NOTCH1 21804540 1961624 Positive_regulation FOXO1 NOX4 21965295 1795282 Positive_regulation FOXO1 NOX4 21965295 1795283 Positive_regulation FOXO1 NPY 24798184 3141734 Positive_regulation FOXO1 NRP1 18000534 2380569 Positive_regulation FOXO1 OPN1LW 24379407 1208826 Positive_regulation FOXO1 OPN1LW 24379407 1208827 Positive_regulation FOXO1 OTC 24787138 2958659 Positive_regulation FOXO1 PAX3 22533991 264554 Positive_regulation FOXO1 PAX3 23206814 3161253 Positive_regulation FOXO1 PAX3 23799156 2807581 Positive_regulation FOXO1 PAX3 23799156 2807583 Positive_regulation FOXO1 PAX3 24453992 2355649 Positive_regulation FOXO1 PAX3 24453992 2355650 Positive_regulation FOXO1 PDCD4 23878722 749582 Positive_regulation FOXO1 PDK1 19808258 1556493 Positive_regulation FOXO1 PDK1 21694754 2528988 Positive_regulation FOXO1 PDK1 21694754 2528990 Positive_regulation FOXO1 PDK1 22586579 722757 Positive_regulation FOXO1 PDK1 22586579 722769 Positive_regulation FOXO1 PDK1 23393571 2751166 Positive_regulation FOXO1 PDK1 23393571 2751174 Positive_regulation FOXO1 PDK4 22911820 2676933 Positive_regulation FOXO1 PDX1 22563476 2626854 Positive_regulation FOXO1 PEA15 22281705 547804 Positive_regulation FOXO1 PGC 17531095 2013453 Positive_regulation FOXO1 PGC 24837835 1126956 Positive_regulation FOXO1 PI3 19765303 1851936 Positive_regulation FOXO1 PI3 20139898 8986 Positive_regulation FOXO1 PI3 23533577 2770605 Positive_regulation FOXO1 PIK3CA 15353558 1533344 Positive_regulation FOXO1 PIK3CA 15353558 1533410 Positive_regulation FOXO1 PIK3CA 18000534 2380570 Positive_regulation FOXO1 PIK3CA 18000534 2380615 Positive_regulation FOXO1 PIK3CA 18355401 1646211 Positive_regulation FOXO1 PIK3CA 19043547 2306822 Positive_regulation FOXO1 PIK3CA 20642839 1647326 Positive_regulation FOXO1 PIK3CA 20657733 2456385 Positive_regulation FOXO1 PIK3CA 21144036 1647956 Positive_regulation FOXO1 PIK3CA 21980390 2560215 Positive_regulation FOXO1 PIK3CA 22477519 1238918 Positive_regulation FOXO1 PIK3CA 22570785 1688284 Positive_regulation FOXO1 PIK3CA 22621320 150573 Positive_regulation FOXO1 PIK3CA 22666216 876683 Positive_regulation FOXO1 PIK3CA 22870349 696156 Positive_regulation FOXO1 PIK3CA 23392169 559407 Positive_regulation FOXO1 PIK3CA 23565490 1044487 Positive_regulation FOXO1 PIK3CA 23638435 943382 Positive_regulation FOXO1 PIK3CA 23995784 2153395 Positive_regulation FOXO1 PIK3CA 24024143 3093161 Positive_regulation FOXO1 PIK3CA 24024143 3093201 Positive_regulation FOXO1 PIK3CA 24765092 912304 Positive_regulation FOXO1 PIK3CA 24876677 1758995 Positive_regulation FOXO1 PIK3CA 25343030 848192 Positive_regulation FOXO1 PIK3R1 15353558 1533345 Positive_regulation FOXO1 PIK3R1 15353558 1533411 Positive_regulation FOXO1 PIK3R1 18000534 2380571 Positive_regulation FOXO1 PIK3R1 18000534 2380616 Positive_regulation FOXO1 PIK3R1 18355401 1646212 Positive_regulation FOXO1 PIK3R1 19043547 2306823 Positive_regulation FOXO1 PIK3R1 20642839 1647327 Positive_regulation FOXO1 PIK3R1 20657733 2456386 Positive_regulation FOXO1 PIK3R1 21144036 1647957 Positive_regulation FOXO1 PIK3R1 21980390 2560216 Positive_regulation FOXO1 PIK3R1 22477519 1238919 Positive_regulation FOXO1 PIK3R1 22570785 1688285 Positive_regulation FOXO1 PIK3R1 22621320 150574 Positive_regulation FOXO1 PIK3R1 22666216 876684 Positive_regulation FOXO1 PIK3R1 22870349 696157 Positive_regulation FOXO1 PIK3R1 23392169 559408 Positive_regulation FOXO1 PIK3R1 23565490 1044488 Positive_regulation FOXO1 PIK3R1 23638435 943383 Positive_regulation FOXO1 PIK3R1 23995784 2153396 Positive_regulation FOXO1 PIK3R1 24024143 3093162 Positive_regulation FOXO1 PIK3R1 24024143 3093202 Positive_regulation FOXO1 PIK3R1 24765092 912305 Positive_regulation FOXO1 PIK3R1 24876677 1758996 Positive_regulation FOXO1 PIK3R1 25343030 848193 Positive_regulation FOXO1 PLSCR4 25369332 3022709 Positive_regulation FOXO1 POLDIP2 20300563 1910603 Positive_regulation FOXO1 PPARA 23372643 2745602 Positive_regulation FOXO1 PPARG 21615920 397986 Positive_regulation FOXO1 PPP2CA 20685959 1779526 Positive_regulation FOXO1 PPP2CA 23202496 3221817 Positive_regulation FOXO1 PPP2CA 23950968 2833055 Positive_regulation FOXO1 PPP2R1A 20685959 1779527 Positive_regulation FOXO1 PPP2R1A 23202496 3221818 Positive_regulation FOXO1 PPP2R1A 23950968 2833056 Positive_regulation FOXO1 PPP2R2B 20685959 1779528 Positive_regulation FOXO1 PPP2R2B 23202496 3221819 Positive_regulation FOXO1 PPP2R2B 23950968 2833057 Positive_regulation FOXO1 PRKAA1 20581852 10154 Positive_regulation FOXO1 PRKAA1 23028378 2338673 Positive_regulation FOXO1 PRKAA1 23055713 1072017 Positive_regulation FOXO1 PRKAA1 23248639 883226 Positive_regulation FOXO1 PRKAA1 23825542 2809544 Positive_regulation FOXO1 PRKAA1 24385923 2354755 Positive_regulation FOXO1 PRKAA1 24454908 2910320 Positive_regulation FOXO1 PRKAA1 25625009 3163437 Positive_regulation FOXO1 PRKAA2 20581852 10155 Positive_regulation FOXO1 PRKAA2 23028378 2338674 Positive_regulation FOXO1 PRKAA2 23055713 1072018 Positive_regulation FOXO1 PRKAA2 23248639 883227 Positive_regulation FOXO1 PRKAA2 23825542 2809545 Positive_regulation FOXO1 PRKAA2 24385923 2354756 Positive_regulation FOXO1 PRKAA2 24454908 2910321 Positive_regulation FOXO1 PRKAA2 25625009 3163438 Positive_regulation FOXO1 PRKAB1 20581852 10156 Positive_regulation FOXO1 PRKAB1 23028378 2338675 Positive_regulation FOXO1 PRKAB1 23055713 1072019 Positive_regulation FOXO1 PRKAB1 23248639 883228 Positive_regulation FOXO1 PRKAB1 23825542 2809546 Positive_regulation FOXO1 PRKAB1 24385923 2354757 Positive_regulation FOXO1 PRKAB1 24454908 2910322 Positive_regulation FOXO1 PRKAB1 25625009 3163439 Positive_regulation FOXO1 PRKAB2 20581852 10157 Positive_regulation FOXO1 PRKAB2 23028378 2338676 Positive_regulation FOXO1 PRKAB2 23055713 1072020 Positive_regulation FOXO1 PRKAB2 23248639 883229 Positive_regulation FOXO1 PRKAB2 23825542 2809547 Positive_regulation FOXO1 PRKAB2 24385923 2354758 Positive_regulation FOXO1 PRKAB2 24454908 2910323 Positive_regulation FOXO1 PRKAB2 25625009 3163440 Positive_regulation FOXO1 PRKAG1 20581852 10158 Positive_regulation FOXO1 PRKAG1 23028378 2338677 Positive_regulation FOXO1 PRKAG1 23055713 1072021 Positive_regulation FOXO1 PRKAG1 23248639 883230 Positive_regulation FOXO1 PRKAG1 23825542 2809548 Positive_regulation FOXO1 PRKAG1 24385923 2354759 Positive_regulation FOXO1 PRKAG1 24454908 2910324 Positive_regulation FOXO1 PRKAG1 25625009 3163441 Positive_regulation FOXO1 PRKAG2 20581852 10159 Positive_regulation FOXO1 PRKAG2 23028378 2338678 Positive_regulation FOXO1 PRKAG2 23055713 1072022 Positive_regulation FOXO1 PRKAG2 23248639 883231 Positive_regulation FOXO1 PRKAG2 23825542 2809549 Positive_regulation FOXO1 PRKAG2 24385923 2354760 Positive_regulation FOXO1 PRKAG2 24454908 2910325 Positive_regulation FOXO1 PRKAG2 25625009 3163442 Positive_regulation FOXO1 PRR5 19209957 2266035 Positive_regulation FOXO1 PRR5 23812589 1990644 Positive_regulation FOXO1 PTEN 20519781 27347 Positive_regulation FOXO1 PTEN 21179458 2488032 Positive_regulation FOXO1 PTEN 24376685 2901830 Positive_regulation FOXO1 PTEN 24962166 1702256 Positive_regulation FOXO1 PTMS 24525530 1940620 Positive_regulation FOXO1 RAB7A 22622703 142856 Positive_regulation FOXO1 RAB7A 24265619 962934 Positive_regulation FOXO1 RAG1 23878308 1572860 Positive_regulation FOXO1 RAG2 23878308 1572861 Positive_regulation FOXO1 RBP4 21804540 1961578 Positive_regulation FOXO1 REL 24380076 864735 Positive_regulation FOXO1 RENBP 17447841 3039584 Positive_regulation FOXO1 RENBP 20300563 1910589 Positive_regulation FOXO1 RENBP 20300563 1910590 Positive_regulation FOXO1 RENBP 20300563 1910594 Positive_regulation FOXO1 RET 25254335 3167420 Positive_regulation FOXO1 RICTOR 19209957 2266034 Positive_regulation FOXO1 RICTOR 22473959 1568005 Positive_regulation FOXO1 RICTOR 22891897 2113408 Positive_regulation FOXO1 RICTOR 23644504 1958901 Positive_regulation FOXO1 RICTOR 23812589 1990643 Positive_regulation FOXO1 RICTOR 24255720 2882068 Positive_regulation FOXO1 RICTOR 24740015 2954376 Positive_regulation FOXO1 RICTOR 24806995 3172269 Positive_regulation FOXO1 RICTOR 24944899 1888076 Positive_regulation FOXO1 RNF19A 24159000 728745 Positive_regulation FOXO1 RPTOR 23183047 1570018 Positive_regulation FOXO1 RPTOR 23183047 1570213 Positive_regulation FOXO1 RUNX1 21765927 2536278 Positive_regulation FOXO1 S1PR1 25330112 3017200 Positive_regulation FOXO1 SCGB1D4 20975207 28364 Positive_regulation FOXO1 SCGB1D4 22016799 2562877 Positive_regulation FOXO1 SCGB1D4 23028355 2338330 Positive_regulation FOXO1 SCGB1D4 23271974 2340597 Positive_regulation FOXO1 SCGB1D4 23906066 700814 Positive_regulation FOXO1 SCGB1D4 24115839 742828 Positive_regulation FOXO1 SCN5A 23393573 2751192 Positive_regulation FOXO1 SETD2 23183047 1569926 Positive_regulation FOXO1 SETD2 23183047 1570016 Positive_regulation FOXO1 SETD2 23183047 1570211 Positive_regulation FOXO1 SETD2 24556689 572295 Positive_regulation FOXO1 SFN 20642839 1647255 Positive_regulation FOXO1 SFN 20642839 1647256 Positive_regulation FOXO1 SFN 20642839 1647322 Positive_regulation FOXO1 SFN 20642839 1647341 Positive_regulation FOXO1 SFN 20642839 1647355 Positive_regulation FOXO1 SFN 20642839 1647372 Positive_regulation FOXO1 SFN 20642839 1647402 Positive_regulation FOXO1 SFN 21804859 813009 Positive_regulation FOXO1 SFN 23799914 1678806 Positive_regulation FOXO1 SGK1 20657733 2456364 Positive_regulation FOXO1 SGK1 20657733 2456381 Positive_regulation FOXO1 SGK1 23467085 1990282 Positive_regulation FOXO1 SGK1 23786484 32932 Positive_regulation FOXO1 SGK1 23786484 32933 Positive_regulation FOXO1 SGK1 23786484 33092 Positive_regulation FOXO1 SGK1 23786484 33093 Positive_regulation FOXO1 SGK1 23786484 33230 Positive_regulation FOXO1 SGK1 23786484 33260 Positive_regulation FOXO1 SGK1 24429466 2186829 Positive_regulation FOXO1 SGTA 19007433 226808 Positive_regulation FOXO1 SIK2 22662228 2647534 Positive_regulation FOXO1 SIN3A 25329053 2365583 Positive_regulation FOXO1 SIRT1 18781224 1054976 Positive_regulation FOXO1 SIRT1 18849969 1982954 Positive_regulation FOXO1 SIRT1 20020036 2434502 Positive_regulation FOXO1 SIRT1 20020036 2434725 Positive_regulation FOXO1 SIRT1 20716932 2222692 Positive_regulation FOXO1 SIRT1 21087523 1696908 Positive_regulation FOXO1 SIRT1 21566744 3188811 Positive_regulation FOXO1 SIRT1 21614150 1057219 Positive_regulation FOXO1 SIRT1 21766030 1155297 Positive_regulation FOXO1 SIRT1 22110478 832208 Positive_regulation FOXO1 SIRT1 22156377 30036 Positive_regulation FOXO1 SIRT1 23285067 2732378 Positive_regulation FOXO1 SIRT1 23342163 2742615 Positive_regulation FOXO1 SIRT1 23843680 1753848 Positive_regulation FOXO1 SIRT1 24009212 781949 Positive_regulation FOXO1 SIRT1 24040102 2845681 Positive_regulation FOXO1 SIRT1 24040102 2845696 Positive_regulation FOXO1 SIRT1 24069505 2226983 Positive_regulation FOXO1 SIRT1 24069505 2226995 Positive_regulation FOXO1 SIRT1 24199159 730962 Positive_regulation FOXO1 SIRT1 24379901 2227819 Positive_regulation FOXO1 SIRT1 24567900 1887689 Positive_regulation FOXO1 SIRT1 24843626 1494162 Positive_regulation FOXO1 SIRT1 24889822 1483437 Positive_regulation FOXO1 SIRT1 25114706 826608 Positive_regulation FOXO1 SIRT1 25610880 1496873 Positive_regulation FOXO1 SIRT2 21566744 3188789 Positive_regulation FOXO1 SIRT2 21566744 3188810 Positive_regulation FOXO1 SIRT3 24454908 2910302 Positive_regulation FOXO1 SKP2 18665269 2394200 Positive_regulation FOXO1 SLC2A4RG 25043713 1943633 Positive_regulation FOXO1 SMAD2 22621320 150612 Positive_regulation FOXO1 SMAD2 22621320 150641 Positive_regulation FOXO1 SMAD3 22621320 150613 Positive_regulation FOXO1 SMAD3 22621320 150642 Positive_regulation FOXO1 SMAD6 24145169 1411669 Positive_regulation FOXO1 SMARCA2 25329053 2365581 Positive_regulation FOXO1 SMARCE1 25329053 2365582 Positive_regulation FOXO1 SMG1 18836529 2397345 Positive_regulation FOXO1 SOD2 15492127 1533797 Positive_regulation FOXO1 SOX2 25369332 3022707 Positive_regulation FOXO1 SP1 21765927 2536279 Positive_regulation FOXO1 SP1 21980390 2560195 Positive_regulation FOXO1 SPDYA 22280365 263360 Positive_regulation FOXO1 SPDYA 22280365 263382 Positive_regulation FOXO1 SPP1 24944898 1888019 Positive_regulation FOXO1 SPRY1 23554919 2773794 Positive_regulation FOXO1 SPRY1 23554919 2773847 Positive_regulation FOXO1 SPRY1 23554919 2773988 Positive_regulation FOXO1 SPRY4 23554919 2773795 Positive_regulation FOXO1 SREBF1 24681808 2188645 Positive_regulation FOXO1 STAT1 23401241 779862 Positive_regulation FOXO1 STAT3 16287709 1538350 Positive_regulation FOXO1 STAT3 17684549 2377529 Positive_regulation FOXO1 STK3 24224013 2877821 Positive_regulation FOXO1 STK4 17907808 2304415 Positive_regulation FOXO1 STK4 19956688 2432395 Positive_regulation FOXO1 STK4 21249150 2493153 Positive_regulation FOXO1 STK4 21249150 2493203 Positive_regulation FOXO1 STK4 24146615 3064628 Positive_regulation FOXO1 STK4 24224013 2877822 Positive_regulation FOXO1 SUPT5H 21423649 2275327 Positive_regulation FOXO1 TARDBP 25329970 2366494 Positive_regulation FOXO1 TCF12 21980390 2560104 Positive_regulation FOXO1 TCF15 21980390 2560105 Positive_regulation FOXO1 TCF19 21980390 2560106 Positive_regulation FOXO1 TCF20 21980390 2560107 Positive_regulation FOXO1 TCF21 21980390 2560108 Positive_regulation FOXO1 TCF23 21980390 2560112 Positive_regulation FOXO1 TCF24 21980390 2560114 Positive_regulation FOXO1 TCF25 21980390 2560113 Positive_regulation FOXO1 TCF3 20543837 1953879 Positive_regulation FOXO1 TCF3 21980390 2560109 Positive_regulation FOXO1 TCF3 22665574 1568306 Positive_regulation FOXO1 TCF4 21980390 2560110 Positive_regulation FOXO1 TCF7 21980390 2560111 Positive_regulation FOXO1 TCF7L2 22892353 521442 Positive_regulation FOXO1 TCF7L2 22934027 958528 Positive_regulation FOXO1 TGFB1 22281705 547803 Positive_regulation FOXO1 TIE1 20805979 2471629 Positive_regulation FOXO1 TIMP3 23401241 779863 Positive_regulation FOXO1 TIMP3 23401241 779867 Positive_regulation FOXO1 TIMP3 23401241 779868 Positive_regulation FOXO1 TLR1 24740015 2953841 Positive_regulation FOXO1 TLR1 24740015 2954365 Positive_regulation FOXO1 TLR10 24740015 2953849 Positive_regulation FOXO1 TLR10 24740015 2954373 Positive_regulation FOXO1 TLR2 24740015 2953842 Positive_regulation FOXO1 TLR2 24740015 2954366 Positive_regulation FOXO1 TLR3 24740015 2953843 Positive_regulation FOXO1 TLR3 24740015 2954367 Positive_regulation FOXO1 TLR4 24740015 2953844 Positive_regulation FOXO1 TLR4 24740015 2954368 Positive_regulation FOXO1 TLR5 24740015 2953845 Positive_regulation FOXO1 TLR5 24740015 2954369 Positive_regulation FOXO1 TLR6 24740015 2953850 Positive_regulation FOXO1 TLR6 24740015 2954374 Positive_regulation FOXO1 TLR7 24740015 2953846 Positive_regulation FOXO1 TLR7 24740015 2954370 Positive_regulation FOXO1 TLR8 24740015 2953847 Positive_regulation FOXO1 TLR8 24740015 2954371 Positive_regulation FOXO1 TLR9 24740015 2953848 Positive_regulation FOXO1 TLR9 24740015 2954372 Positive_regulation FOXO1 TMEM135 21151927 2485360 Positive_regulation FOXO1 TMEM135 21151927 2485366 Positive_regulation FOXO1 TNF 19168598 707801 Positive_regulation FOXO1 TNF 19168598 707802 Positive_regulation FOXO1 TNF 19168598 707803 Positive_regulation FOXO1 TNF 19168598 707804 Positive_regulation FOXO1 TNF 20200974 1237343 Positive_regulation FOXO1 TNF 20200974 1237357 Positive_regulation FOXO1 TNF 20200974 1237360 Positive_regulation FOXO1 TNF 20300563 1910585 Positive_regulation FOXO1 TNF 20300563 1910586 Positive_regulation FOXO1 TNF 20300563 1910587 Positive_regulation FOXO1 TNF 20300563 1910597 Positive_regulation FOXO1 TNF 20300563 1910602 Positive_regulation FOXO1 TNF 22454632 832688 Positive_regulation FOXO1 TNF 22454632 832737 Positive_regulation FOXO1 TNF 23484152 179739 Positive_regulation FOXO1 TNF 23499576 3204107 Positive_regulation FOXO1 TNF 24864265 191778 Positive_regulation FOXO1 TNF 24864265 191783 Positive_regulation FOXO1 TNF 24971753 2985025 Positive_regulation FOXO1 TNF 25162582 3002803 Positive_regulation FOXO1 TNF 25162582 3002946 Positive_regulation FOXO1 TNF 25162582 3002956 Positive_regulation FOXO1 TNF 25226535 1130156 Positive_regulation FOXO1 TNFRSF9 23874982 2823968 Positive_regulation FOXO1 TNFSF11 24781012 1941824 Positive_regulation FOXO1 TNFSF11 24836538 2971302 Positive_regulation FOXO1 TNFSF13B 17060474 1543041 Positive_regulation FOXO1 TNK2 20333297 2444175 Positive_regulation FOXO1 TRIM63 18047744 226232 Positive_regulation FOXO1 TRIM63 23555761 2775264 Positive_regulation FOXO1 TRIM63 25294954 1762717 Positive_regulation FOXO1 TRIM63 25625009 3163484 Positive_regulation FOXO1 TSC22D3 23516608 2768728 Positive_regulation FOXO1 TST 22280365 263359 Positive_regulation FOXO1 TST 22280365 263381 Positive_regulation FOXO1 TXNIP 24112473 270030 Positive_regulation FOXO1 UGCG 23154295 2110539 Positive_regulation FOXO1 USP13 24270891 1930377 Positive_regulation FOXO1 VAV1 21957439 2557183 Positive_regulation FOXO1 VEGFA 18000534 2380608 Positive_regulation FOXO1 WAS 22156377 29990 Positive_regulation FOXO1 WAS 22156377 29991 Positive_regulation FOXO1 WAS 22156377 30066 Positive_regulation FOXO1 WAS 22156377 30074 Positive_regulation FOXO1 WNT3A 24466091 2913267 Positive_regulation FOXO1 XBP1 23277279 610794 Positive_regulation FOXO1 XBP1 23277279 610795 Positive_regulation FOXO1 XBP1 23277279 610796 Positive_regulation FOXO1 XBP1 23277279 610797 Positive_regulation FOXO1 XBP1 23277279 610808 Positive_regulation FOXO1 XBP1 23277279 610809 Positive_regulation FOXO1 XBP1 23277279 610843 Positive_regulation FOXO1 XBP1 23277279 610863 Positive_regulation FOXO1 XBP1 23277279 610870 Positive_regulation FOXO1 XBP1 23277279 610871 Positive_regulation FOXO1 XBP1 23277279 610876 Positive_regulation FOXO1 XBP1 23277279 610877 Positive_regulation FOXO1 XBP1 23277279 610925 Positive_regulation FOXO1 XBP1 23277279 610926 Positive_regulation FOXO1 XBP1 23572207 3158226 Positive_regulation FOXO1 XBP1 23572207 3158241 Positive_regulation FOXO1 XBP1 23572207 3158246 Positive_regulation FOXO1 XBP1 24339733 1062290 Positive_regulation FOXO1 XBP1 24683410 1226791 Positive_regulation FOXO1 XBP1 25216759 1896295 Positive_regulation FOXO1 ZGLP1 22013015 720939 Positive_regulation FOXO3 EPHB2 20858281 1859197 Positive_regulation FOXO3 EPHB2 21980390 2560217 Positive_regulation FOXO3 EPHB2 22242005 2328375 Positive_regulation FOXO3 EPHB2 22649777 939919 Positive_regulation FOXO3 FAS 18312651 462641 Positive_regulation FOXO3 FBXO32 18047744 226235 Positive_regulation FOXO3 FBXO32 21483870 2512554 Positive_regulation FOXO3 FBXO32 25625009 3163487 Positive_regulation FOXO3 FOXO1 20642839 1647360 Positive_regulation FOXO3 FOXO1 21179458 2488015 Positive_regulation FOXO3 FOXO1 21179458 2488016 Positive_regulation FOXO3 FOXO1 21980390 2560218 Positive_regulation FOXO3 FOXO1 23555761 2775261 Positive_regulation FOXO3 FOXO1 23800068 830115 Positive_regulation FOXO3 FOXO1 24265696 2884926 Positive_regulation FOXO3 FOXO1 24757526 1491700 Positive_regulation FOXO3 FOXO1 25136826 2998914 Positive_regulation FOXO3 FOXO1 25546383 3036503 Positive_regulation FOXO3 IFI27 14734530 1304598 Positive_regulation FOXO3 IFI27 23259070 1719097 Positive_regulation FOXO3 IFI27 23691078 2794268 Positive_regulation FOXO3 IFI27 23907123 543973 Positive_regulation FOXO3 PGC 24801481 2961423 Positive_regulation FOXO3 SPHK1 21625639 2525202 Positive_regulation FOXO3 SPHK1 21625639 2525206 Positive_regulation FOXO3 SPHK1 21625639 2525208 Positive_regulation FOXO3 SPHK1 21625639 2525209 Positive_regulation FOXO3 SPHK1 21625639 2525216 Positive_regulation FOXO3 SPHK1 21625639 2525217 Positive_regulation FOXO3 SPHK1 21625639 2525226 Positive_regulation FOXO3 SPHK1 25109605 2171856 Positive_regulation FOXO3 SPHK1 25109605 2171857 Positive_regulation FOXO3 TNF 23499576 3204111 Positive_regulation FOXO3 TNFSF10 23828551 2183555 Positive_regulation FOXO4 EPHB2 22242005 2328398 Positive_regulation FOXO4 EPHB2 22649777 939946 Positive_regulation FOXO4 FBXO32 18047744 226237 Positive_regulation FOXO4 FBXO32 25625009 3163489 Positive_regulation FOXO4 FOXO1 20642839 1647364 Positive_regulation FOXO4 FOXO1 21179458 2488021 Positive_regulation FOXO4 FOXO1 21980390 2560223 Positive_regulation FOXO4 FOXO1 23555761 2775262 Positive_regulation FOXO4 FOXO1 23800068 830142 Positive_regulation FOXO4 FOXO1 24757526 1491701 Positive_regulation FOXO4 FOXO1 25136826 2998915 Positive_regulation FOXO4 TNF 23499576 3204115 Positive_regulation FOXO4 TNF 23840100 1753481 Positive_regulation FOXO6 EPHB2 22242005 2328345 Positive_regulation FOXO6 EPHB2 22649777 939901 Positive_regulation FOXO6 FBXO32 18047744 226231 Positive_regulation FOXO6 FBXO32 25625009 3163483 Positive_regulation FOXO6 FOXO1 20642839 1647352 Positive_regulation FOXO6 FOXO1 21179458 2488006 Positive_regulation FOXO6 FOXO1 21980390 2560204 Positive_regulation FOXO6 FOXO1 23555761 2775259 Positive_regulation FOXO6 FOXO1 23800068 830104 Positive_regulation FOXO6 FOXO1 25136826 2998912 Positive_regulation FOXO6 PGC 23639108 213493 Positive_regulation FOXO6 PGC 23639108 213502 Positive_regulation FOXO6 PGC 23639108 213513 Positive_regulation FOXO6 TNF 23499576 3204103 Positive_regulation FOXP3 EPHB2 20967853 135172 Positive_regulation FOXP3 FOXO1 20439537 1558142 Positive_regulation FOXP3 FOXO1 20439537 1558155 Positive_regulation FOXP3 FOXO1 21390257 2506363 Positive_regulation FOXP3 FOXO1 22550535 634384 Positive_regulation FOXP3 HES2 20876311 1560339 Positive_regulation FOXP3 HES2 20876311 1560340 Positive_regulation FOXP3 HES2 20876311 1560341 Positive_regulation FOXP3 HES2 20876311 1560404 Positive_regulation FOXP3 HES2 22110392 1058602 Positive_regulation FOXP3 HES2 22262943 1223709 Positive_regulation FOXP3 HES2 23053394 3158183 Positive_regulation FOXP3 IFI27 21326316 988595 Positive_regulation FOXP3 PLAU 23169000 1904604 Positive_regulation FOXP3 RORC 22259252 1628426 Positive_regulation FOXP3 RORC 22259252 1628427 Positive_regulation FOXP3 TCN1 23964850 3210564 Positive_regulation FOXP3 TCN1 23964850 3210565 Positive_regulation FOXP3 TCN1 23964850 3210566 Positive_regulation FOXP3 TLR7 19204112 1554061 Positive_regulation FOXP3 TLR7 25147831 1623114 Positive_regulation FOXP3 TNF 19343213 3043703 Positive_regulation FOXP3 TNF 24193319 3138593 Positive_regulation FOXQ1 KDM3A 22581778 2075297 Positive_regulation FOXQ1 KDM3A 22581778 2075298 Positive_regulation FOXQ1 KDM3A 22581778 2075308 Positive_regulation FOXQ1 S100A4 25356753 2206495 Positive_regulation FOXQ1 VIM 25356753 2206496 Positive_regulation FPR1 TNF 12930553 658493 Positive_regulation FRS2 EPHB2 20032303 1772533 Positive_regulation FSCN1 TNF 24857932 2973153 Positive_regulation FSCN1 TNF 24857932 2973159 Positive_regulation FSHB FOXO1 25423188 3030068 Positive_regulation FSHR EPHB2 22666216 876686 Positive_regulation FST MSX1 23316168 960730 Positive_regulation FSTL1 TNF 18195069 1548431 Positive_regulation FSTL1 TNF 19966777 1960924 Positive_regulation FSTL1 TNF 24347831 1755753 Positive_regulation FSTL1 TNF 24347831 1755788 Positive_regulation FSTL1 TNF 24347831 1755830 Positive_regulation FSTL1 TNF 24347831 1755865 Positive_regulation FSTL1 TNF 25093709 34347 Positive_regulation FTH1 TNF 25255103 3069561 Positive_regulation FTH1 TNF 2921280 1424435 Positive_regulation FUBP1 FOLR1 20485488 2271770 Positive_regulation FURIN MMP28 11044366 418075 Positive_regulation FURIN MMP7 11044366 418090 Positive_regulation FUS PCSK9 9606213 1467800 Positive_regulation FUT1 CD14 20548789 2452770 Positive_regulation FUT1 CD14 23259611 856257 Positive_regulation FUT1 CTGF 23441194 2757015 Positive_regulation FUT1 HBEGF 22330337 1717967 Positive_regulation FUT1 HBEGF 22330337 1717972 Positive_regulation FUT1 ID1 23383338 2750423 Positive_regulation FUT1 ITGAL 24749071 3166656 Positive_regulation FUT1 ITGB2 22762001 413489 Positive_regulation FUT1 TLR7 20706677 979153 Positive_regulation FUT1 TLR7 20706677 979186 Positive_regulation FUT1 TLR7 23882270 908323 Positive_regulation FUT1 TNF 21626291 616648 Positive_regulation FUT1 TNF 21626291 616649 Positive_regulation FUT1 TNF 21768269 1564320 Positive_regulation FUT1 TNF 22661952 957361 Positive_regulation FUT1 TNF 23882270 908330 Positive_regulation FUT1 TNF 24066058 2850763 Positive_regulation FUT1 TNF 24978432 504608 Positive_regulation FUT4 AKT1 23887626 564157 Positive_regulation FUT4 AKT2 23887626 564158 Positive_regulation FUT4 AKT3 23887626 564159 Positive_regulation FUT4 FUT7 8666674 1452114 Positive_regulation FUT4 HNF1A 21203500 2320864 Positive_regulation FUT4 HNF1A 24069312 2852694 Positive_regulation FUT4 HNF4A 21203500 2320865 Positive_regulation FUT4 MYB 22709531 482570 Positive_regulation FXN PGC 23418481 2753995 Positive_regulation FXR1 EPHB2 23104131 1962440 Positive_regulation FXR1 PGC 21857965 2544439 Positive_regulation FXR1 PGC 21857965 2544444 Positive_regulation FXR1 PGC 22577560 1639173 Positive_regulation FXR2 EPHB2 23104131 1962442 Positive_regulation FXR2 PGC 21857965 2544440 Positive_regulation FXR2 PGC 21857965 2544445 Positive_regulation FXR2 PGC 22577560 1639174 Positive_regulation FXYD1 EPHB2 23984088 1150959 Positive_regulation FXYD1 PLAU 20976186 2479438 Positive_regulation FXYD1 TNF 24367694 2900585 Positive_regulation FXYD1 TNF 24367694 2900588 Positive_regulation FYB ITGAL 22672517 532749 Positive_regulation FYN NEDD9 11097209 702085 Positive_regulation FYN NGFR 22880054 2673806 Positive_regulation FZD4 CDC42 23593172 2780065 Positive_regulation FZD4 DVL1 22645520 874074 Positive_regulation FZD4 DVL2 22645520 874075 Positive_regulation FZD4 DVL3 22645520 874076 Positive_regulation FZD4 ERG 24739220 484373 Positive_regulation FZD4 ERG 24948871 1063028 Positive_regulation FZD4 FZD9 23401003 1402289 Positive_regulation FZD4 LGR5 24349440 2897999 Positive_regulation FZD4 LRP1 22645520 874078 Positive_regulation FZD4 LRP10 22645520 874071 Positive_regulation FZD4 LRP11 22645520 874073 Positive_regulation FZD4 LRP12 22645520 874077 Positive_regulation FZD4 LRP2 22645520 874079 Positive_regulation FZD4 LRP3 22645520 874080 Positive_regulation FZD4 LRP4 22645520 874081 Positive_regulation FZD4 LRP5 22645520 874082 Positive_regulation FZD4 LRP5 23469146 2762134 Positive_regulation FZD4 LRP6 22645520 874083 Positive_regulation FZD4 LRP6 23469146 2762135 Positive_regulation FZD4 LRP8 22645520 874084 Positive_regulation FZD4 MYLIP 25018733 965451 Positive_regulation FZD4 NDP 20652025 2456176 Positive_regulation FZD4 RSPO1 24349440 2897998 Positive_regulation FZD4 SLC9A3R1 20802536 2135905 Positive_regulation FZD4 SOX9 25277175 2202886 Positive_regulation FZD4 WNT1 17386109 279578 Positive_regulation FZD4 WNT1 17897439 461318 Positive_regulation FZD4 WNT1 19473496 464409 Positive_regulation FZD4 WNT1 21668411 149134 Positive_regulation FZD4 WNT1 22019198 2252810 Positive_regulation FZD4 WNT1 22372892 238360 Positive_regulation FZD4 WNT1 22645520 874065 Positive_regulation FZD4 WNT1 23401003 1402282 Positive_regulation FZD4 WNT1 24132329 3138034 Positive_regulation FZD4 WNT1 24252524 538368 Positive_regulation FZD4 WNT1 24455745 186501 Positive_regulation FZD4 WNT11 17386109 279579 Positive_regulation FZD4 WNT11 17897439 461319 Positive_regulation FZD4 WNT11 21668411 149135 Positive_regulation FZD4 WNT11 22019198 2252811 Positive_regulation FZD4 WNT11 22372892 238361 Positive_regulation FZD4 WNT11 22645520 874066 Positive_regulation FZD4 WNT11 23401003 1402283 Positive_regulation FZD4 WNT11 24132329 3138035 Positive_regulation FZD4 WNT11 24252524 538369 Positive_regulation FZD4 WNT11 24455745 186502 Positive_regulation FZD4 WNT16 17386109 279584 Positive_regulation FZD4 WNT16 17897439 461324 Positive_regulation FZD4 WNT16 21668411 149140 Positive_regulation FZD4 WNT16 22019198 2252816 Positive_regulation FZD4 WNT16 22372892 238366 Positive_regulation FZD4 WNT16 22645520 874072 Positive_regulation FZD4 WNT16 23401003 1402288 Positive_regulation FZD4 WNT16 24132329 3138040 Positive_regulation FZD4 WNT16 24252524 538374 Positive_regulation FZD4 WNT16 24455745 186507 Positive_regulation FZD4 WNT2 17386109 279580 Positive_regulation FZD4 WNT2 17386109 279592 Positive_regulation FZD4 WNT2 17897439 461320 Positive_regulation FZD4 WNT2 21668411 149136 Positive_regulation FZD4 WNT2 22019198 2252812 Positive_regulation FZD4 WNT2 22372892 238362 Positive_regulation FZD4 WNT2 22645520 874067 Positive_regulation FZD4 WNT2 23401003 1402284 Positive_regulation FZD4 WNT2 24132329 3138036 Positive_regulation FZD4 WNT2 24252524 538370 Positive_regulation FZD4 WNT2 24455745 186503 Positive_regulation FZD4 WNT3 17386109 279581 Positive_regulation FZD4 WNT3 17897439 461321 Positive_regulation FZD4 WNT3 21668411 149137 Positive_regulation FZD4 WNT3 22019198 2252813 Positive_regulation FZD4 WNT3 22372892 238363 Positive_regulation FZD4 WNT3 22645520 874068 Positive_regulation FZD4 WNT3 23401003 1402285 Positive_regulation FZD4 WNT3 24132329 3138037 Positive_regulation FZD4 WNT3 24252524 538371 Positive_regulation FZD4 WNT3 24455745 186504 Positive_regulation FZD4 WNT3A 19672307 2423683 Positive_regulation FZD4 WNT3A 20957030 2477707 Positive_regulation FZD4 WNT3A 24349440 2897997 Positive_regulation FZD4 WNT4 17386109 279582 Positive_regulation FZD4 WNT4 17897439 461322 Positive_regulation FZD4 WNT4 21668411 149138 Positive_regulation FZD4 WNT4 22019198 2252814 Positive_regulation FZD4 WNT4 22372892 238364 Positive_regulation FZD4 WNT4 22645520 874069 Positive_regulation FZD4 WNT4 23401003 1402286 Positive_regulation FZD4 WNT4 24132329 3138038 Positive_regulation FZD4 WNT4 24252524 538372 Positive_regulation FZD4 WNT4 24455745 186505 Positive_regulation FZD4 WNT6 17386109 279583 Positive_regulation FZD4 WNT6 17897439 461323 Positive_regulation FZD4 WNT6 21668411 149139 Positive_regulation FZD4 WNT6 22019198 2252815 Positive_regulation FZD4 WNT6 22372892 238365 Positive_regulation FZD4 WNT6 22645520 874070 Positive_regulation FZD4 WNT6 23401003 1402287 Positive_regulation FZD4 WNT6 24132329 3138039 Positive_regulation FZD4 WNT6 24252524 538373 Positive_regulation FZD4 WNT6 24455745 186506 Positive_regulation FZD7 WNT7A 22179044 1928034 Positive_regulation FZD9 FZD4 23401003 1402333 Positive_regulation G0S2 INS 24440819 159652 Positive_regulation G6PC FOXO1 21304897 2500034 Positive_regulation G6PC FOXO1 21559261 3128190 Positive_regulation G6PC FOXO1 21804540 1961579 Positive_regulation G6PC FOXO1 21804540 1961587 Positive_regulation G6PC FOXO1 21804540 1961625 Positive_regulation G6PC FOXO1 21804540 1961630 Positive_regulation G6PC FOXO1 22577560 1639175 Positive_regulation G6PC FOXO1 23442260 1036518 Positive_regulation G6PC FOXO1 25136826 2998911 Positive_regulation G6PC FOXO1 25222566 3007463 Positive_regulation G6PC PGC 20393151 713809 Positive_regulation G6PC PGC 23274887 725472 Positive_regulation G6PC PGC 23442260 1036519 Positive_regulation G6PC PGC 23442260 1036522 Positive_regulation GAB1 EPHB2 17158954 1335297 Positive_regulation GAB1 PECAM1 20723025 1692076 Positive_regulation GAB2 STK39 21994618 3219322 Positive_regulation GAB2 STK39 21994618 3219372 Positive_regulation GAB3 CSF1 22216034 22238 Positive_regulation GAB3 IL6 20689230 3079083 Positive_regulation GAB3 PTPN11 21687723 922315 Positive_regulation GAB3 VASP 21041447 1381587 Positive_regulation GAB3 VEGFA 23805312 2808379 Positive_regulation GABARAPL1 CAPN8 24350057 946776 Positive_regulation GABBR1 EPHB2 23908646 878993 Positive_regulation GABBR2 EPHB2 23908646 878994 Positive_regulation GABPA CCND1 18959794 1616168 Positive_regulation GABPA EPHB2 23738323 181941 Positive_regulation GABPA EPHB2 23762139 820040 Positive_regulation GABPA EPHB2 24737944 842097 Positive_regulation GABPA EPHB2 24839356 1758767 Positive_regulation GABPA EPHB2 25007817 1128331 Positive_regulation GABPA EPHB2 25353254 1731133 Positive_regulation GABPA EPHB2 25353254 1731150 Positive_regulation GABPA LBP 25045414 2229604 Positive_regulation GABPA LBP 25045414 2229617 Positive_regulation GABPA LBP 25045414 2229620 Positive_regulation GABPA LBP 25045414 2229621 Positive_regulation GABPA LBP 25045414 2229625 Positive_regulation GABPA LBP 25045414 2229628 Positive_regulation GABPA PGC 20491655 147796 Positive_regulation GABPA PGC 22072942 1091853 Positive_regulation GADD45A EPHB2 21286247 1028327 Positive_regulation GADD45A FOXO1 18086917 1347170 Positive_regulation GADD45A FOXO1 21835778 2065746 Positive_regulation GADD45A FOXO1 22454632 832698 Positive_regulation GADD45A FOXO1 24145170 1411728 Positive_regulation GADD45A MAP2K6 21286247 1028337 Positive_regulation GADD45A TNF 22253905 2588320 Positive_regulation GADD45A TNF 22719951 2653892 Positive_regulation GADD45A TNF 23681232 561820 Positive_regulation GADD45B TNF 18789159 1646386 Positive_regulation GADD45B TNF 21738489 2325078 Positive_regulation GADD45G TNF 25248126 3009307 Positive_regulation GAL CTGF 22684333 541568 Positive_regulation GAL GNE 20383336 2445907 Positive_regulation GAL KRT38 20582323 2271950 Positive_regulation GAL KRT38 20582323 2271953 Positive_regulation GAL LGALS7B 21624158 1234852 Positive_regulation GAL SELL 10330415 1246423 Positive_regulation GALT TNF 16100442 1634478 Positive_regulation GALT TNF 23304632 1082731 Positive_regulation GAP43 EPHB2 22931352 1231158 Positive_regulation GAP43 NES 23938193 510175 Positive_regulation GAPDH EPHB2 23603840 2183073 Positive_regulation GAPDH RNASE1 19528073 2046530 Positive_regulation GAPDH RNASE7 19528073 2046538 Positive_regulation GAPDH TNF 24990076 742255 Positive_regulation GARS EPHB2 23427196 780082 Positive_regulation GAS1 EMP1 10704443 1256231 Positive_regulation GAST CCND1 15798764 425451 Positive_regulation GAST CCND1 22276155 2590211 Positive_regulation GAST HBEGF 25346875 2231112 Positive_regulation GAST JAG1 23805861 343860 Positive_regulation GAST PGC 12698190 422482 Positive_regulation GAST SLC38A3 9041688 3230203 Positive_regulation GATA1 FAS 11208865 1518753 Positive_regulation GATA1 FOXO1 23271974 2340545 Positive_regulation GATA1 MAP2K6 23717580 2798244 Positive_regulation GATA2 FHL1 19075112 1362570 Positive_regulation GATA2 FOXO1 23271974 2340549 Positive_regulation GATA3 FOXO1 23271974 2340553 Positive_regulation GATA3 HES2 20876311 1560396 Positive_regulation GATA3 STAT4 20499411 3231816 Positive_regulation GATA3 STAT4 23345540 2209511 Positive_regulation GATA3 ZFP57 23684985 1040967 Positive_regulation GATA3 ZFP57 23684985 1040990 Positive_regulation GATA4 EPHB2 21702924 508546 Positive_regulation GATA4 EPHB2 21702924 508547 Positive_regulation GATA4 EPHB2 22257425 508859 Positive_regulation GATA4 FOXA1 24963715 2983456 Positive_regulation GATA4 FOXO1 23271974 2340557 Positive_regulation GATA4 MAP2K6 21702924 508558 Positive_regulation GATA4 MAP2K6 21702924 508559 Positive_regulation GATA4 MAP2K6 22257425 508865 Positive_regulation GATA5 FOXO1 23271974 2340541 Positive_regulation GATA6 FOXO1 23271974 2340561 Positive_regulation GBP1 TNF 17822540 395878 Positive_regulation GBP1 TNF 23186538 3215193 Positive_regulation GC TNF 22225630 124575 Positive_regulation GC TNF 22225630 124582 Positive_regulation GCG ADRB2 22013013 720893 Positive_regulation GCG FOXA1 17907808 2304408 Positive_regulation GCG FOXO1 24379407 1208856 Positive_regulation GCG GLP1R 22438981 2612718 Positive_regulation GCG GLP1R 23649520 727267 Positive_regulation GCG GLP1R 24712679 451615 Positive_regulation GCG PGC 24147136 2870896 Positive_regulation GCG TNF 3351436 1581117 Positive_regulation GCG TSPAN1 23840313 2812576 Positive_regulation GCHFR CAPN8 19830249 1213131 Positive_regulation GCHFR CAPN8 20200223 1774825 Positive_regulation GCHFR CAPN8 20200223 1774840 Positive_regulation GCHFR CAPN8 20200223 1774919 Positive_regulation GCHFR CAPN8 20711428 2459085 Positive_regulation GCHFR CAPN8 22792491 2002862 Positive_regulation GCHFR CAPN8 25093719 2995282 Positive_regulation GCHFR CCND1 22833568 1806166 Positive_regulation GCHFR IFI27 21566658 547254 Positive_regulation GCHFR NES 19668434 649340 Positive_regulation GCHFR NES 21278733 1966566 Positive_regulation GCHFR TLR7 24379524 1756097 Positive_regulation GCHFR TNF 21736731 1898346 Positive_regulation GCHFR TNF 21736731 1898347 Positive_regulation GCHFR TNF 21736731 1898352 Positive_regulation GCK LBP 25045414 2229609 Positive_regulation GCNT2 TNF 24624332 3094232 Positive_regulation GDAP1L1 PGC 24480485 452243 Positive_regulation GDF10 TNF 19617892 7916 Positive_regulation GDF15 MMP28 18778487 384832 Positive_regulation GDF2 ID1 25393508 1134136 Positive_regulation GDNF EPHB2 19649251 2422259 Positive_regulation GDNF EPHB2 19649251 2422270 Positive_regulation GDNF EPHB2 23151666 1086783 Positive_regulation GDNF NPNT 22613833 1397799 Positive_regulation GDNF TNF 23151666 1086782 Positive_regulation GEMIN2 CAPN8 21209906 2491956 Positive_regulation GEMIN2 SMN2 17984321 1346053 Positive_regulation GEMIN2 SMN2 18791638 2396435 Positive_regulation GEMIN2 SMN2 20019802 2312080 Positive_regulation GEMIN2 SMN2 21339974 1090511 Positive_regulation GEMIN2 SMN2 21490958 2323983 Positive_regulation GEMIN2 SMN2 23615451 1813936 Positive_regulation GEMIN2 SMN2 23615451 1814014 Positive_regulation GEMIN2 SMN2 23631896 1881383 Positive_regulation GEMIN2 TNF 24237934 1481899 Positive_regulation GEMIN4 SMN2 17984321 1346151 Positive_regulation GEMIN4 SMN2 18791638 2396463 Positive_regulation GEMIN4 SMN2 20019802 2312130 Positive_regulation GEMIN4 SMN2 21339974 1090539 Positive_regulation GEMIN4 SMN2 21490958 2324068 Positive_regulation GEMIN4 SMN2 23615451 1813954 Positive_regulation GEMIN4 SMN2 23615451 1814078 Positive_regulation GEMIN4 SMN2 23631896 1881483 Positive_regulation GEMIN5 CAPN8 21209906 2491984 Positive_regulation GEMIN5 SMN2 17984321 1346167 Positive_regulation GEMIN5 SMN2 18791638 2396470 Positive_regulation GEMIN5 SMN2 20019802 2312135 Positive_regulation GEMIN5 SMN2 21339974 1090546 Positive_regulation GEMIN5 SMN2 21490958 2324075 Positive_regulation GEMIN5 SMN2 23615451 1813958 Positive_regulation GEMIN5 SMN2 23615451 1814094 Positive_regulation GEMIN5 SMN2 23631896 1881493 Positive_regulation GEMIN6 SMN2 17984321 1346183 Positive_regulation GEMIN6 SMN2 18791638 2396477 Positive_regulation GEMIN6 SMN2 20019802 2312140 Positive_regulation GEMIN6 SMN2 21339974 1090553 Positive_regulation GEMIN6 SMN2 21490958 2324082 Positive_regulation GEMIN6 SMN2 23615451 1813963 Positive_regulation GEMIN6 SMN2 23615451 1814110 Positive_regulation GEMIN6 SMN2 23631896 1881503 Positive_regulation GEMIN7 SMN2 17984321 1346199 Positive_regulation GEMIN7 SMN2 18791638 2396484 Positive_regulation GEMIN7 SMN2 20019802 2312145 Positive_regulation GEMIN7 SMN2 21339974 1090560 Positive_regulation GEMIN7 SMN2 21490958 2324089 Positive_regulation GEMIN7 SMN2 23615451 1813967 Positive_regulation GEMIN7 SMN2 23615451 1814126 Positive_regulation GEMIN7 SMN2 23631896 1881513 Positive_regulation GEN1 NES 25209024 1945970 Positive_regulation GFAP CTGF 22511849 1914260 Positive_regulation GFAP JAG1 23759991 1107727 Positive_regulation GFAP NES 21304179 2174843 Positive_regulation GFAP NES 22650359 1506415 Positive_regulation GFAP S100B 23259641 1665803 Positive_regulation GFAP TCN1 24735601 1667971 Positive_regulation GFAP TCN1 24735601 1667987 Positive_regulation GFAP TCN1 24735601 1667988 Positive_regulation GFAP TCN1 24735601 1668004 Positive_regulation GFAP TNF 20003262 1655811 Positive_regulation GGNBP2 CCND1 17407548 1846372 Positive_regulation GGNBP2 CCND1 17407548 1846377 Positive_regulation GH1 TMEM100 22500953 355658 Positive_regulation GH1 TMEM156 22500953 355676 Positive_regulation GH1 TMEM211 22500953 355757 Positive_regulation GH1 TMEM213 22500953 355693 Positive_regulation GHITM EPHB2 21909400 2551986 Positive_regulation GHR EMP1 25101218 1708815 Positive_regulation GHR EPHB2 22649371 874994 Positive_regulation GHSR EPHB2 19262695 2406773 Positive_regulation GIF TNF 18474096 110750 Positive_regulation GIF TNF 19088872 2219128 Positive_regulation GIF TNF 24648814 1712222 Positive_regulation GIF TNF 8318425 444696 Positive_regulation GIP CCND1 24843404 1492970 Positive_regulation GIPR GLP1R 22412906 2609683 Positive_regulation GJA1 EFNB1 16968134 2261908 Positive_regulation GJA1 IFI27 24056538 3137233 Positive_regulation GJA1 TLR7 24236122 2878633 Positive_regulation GJA1 TNF 22096383 1030534 Positive_regulation GJA1 TNF 23737642 1753152 Positive_regulation GJA1 TNF 24236122 2878617 Positive_regulation GJA1 TNF 24236122 2878638 Positive_regulation GJA1 TNF 25301274 1763023 Positive_regulation GJB2 CDH1 9722615 1470565 Positive_regulation GJB2 DSC1 24931423 1681387 Positive_regulation GJB2 DSC2 24931423 1681388 Positive_regulation GJB2 DSC3 24931423 1681389 Positive_regulation GJB2 GJB1 23590695 1683795 Positive_regulation GJB2 MBD2 23579952 1105438 Positive_regulation GJB2 MT-CO2 24847209 869325 Positive_regulation GJB4 DSC1 24931423 1681393 Positive_regulation GJB4 DSC2 24931423 1681394 Positive_regulation GJB4 DSC3 24931423 1681395 Positive_regulation GK PGC 24172199 828850 Positive_regulation GLA TNF 22829921 2667897 Positive_regulation GLB1 FOXO1 23874301 961634 Positive_regulation GLB1 MGAM 19761587 313154 Positive_regulation GLI1 CCND1 17408503 401055 Positive_regulation GLI1 EPHB2 20865152 2291851 Positive_regulation GLI1 EPHB2 20865152 2291883 Positive_regulation GLI1 EPHB2 21860067 2176439 Positive_regulation GLI1 EPHB2 23900341 2183749 Positive_regulation GLI1 EPHB2 23935925 2828399 Positive_regulation GLI1 MAP2K6 20941789 775407 Positive_regulation GLI1 MAP2K6 20941789 775408 Positive_regulation GLI1 MAP2K6 20941789 775510 Positive_regulation GLI1 MAP2K6 21860067 2176445 Positive_regulation GLI1 MAP2K6 23436775 780171 Positive_regulation GLI1 MAP2K6 23900341 2183755 Positive_regulation GLI1 MAP2K6 23935925 2828408 Positive_regulation GLI1 MAP2K6 23935925 2828435 Positive_regulation GLI1 MAP2K6 24852887 3157796 Positive_regulation GLI1 STK39 24810746 2962740 Positive_regulation GLMN FAS 23840967 1154194 Positive_regulation GLP1R CALCA 22693487 833127 Positive_regulation GLP1R EXD1 22438981 2612721 Positive_regulation GLP1R EXD2 22438981 2612719 Positive_regulation GLP1R EXD3 22438981 2612720 Positive_regulation GLP1R GCG 22438981 2612722 Positive_regulation GLP1R GCG 24712679 451616 Positive_regulation GLP1R GCK 23284795 2731008 Positive_regulation GLP1R HMOX1 20364157 9781 Positive_regulation GLP1R IFI44 24843641 1494254 Positive_regulation GLP1R INS 19592625 729250 Positive_regulation GLP1R INS 20823098 716467 Positive_regulation GLP1R INS 22666230 833109 Positive_regulation GLP1R INS 25413047 733862 Positive_regulation GLP1R ISL1 23193182 725129 Positive_regulation GLP1R ISL1 23518338 699064 Positive_regulation GLP1R LEPR 22249232 1140324 Positive_regulation GLP1R MAFA 24843642 1494464 Positive_regulation GLP1R MAPK1 24843641 1494257 Positive_regulation GLP1R MAPK10 24843641 1494258 Positive_regulation GLP1R MAPK11 24843641 1494259 Positive_regulation GLP1R MAPK12 24843641 1494260 Positive_regulation GLP1R MAPK13 24843641 1494261 Positive_regulation GLP1R MAPK14 24843641 1494262 Positive_regulation GLP1R MAPK15 24843641 1494256 Positive_regulation GLP1R MAPK3 24843641 1494263 Positive_regulation GLP1R MAPK4 24843641 1494264 Positive_regulation GLP1R MAPK6 24843641 1494265 Positive_regulation GLP1R MAPK7 24843641 1494266 Positive_regulation GLP1R MAPK8 24843641 1494267 Positive_regulation GLP1R MAPK9 24843641 1494268 Positive_regulation GLP1R NPAS4 23656887 727307 Positive_regulation GLP1R NPPA 25061556 1888235 Positive_regulation GLP1R NUP43 24843641 1494255 Positive_regulation GLP1R PAEP 25553112 3177731 Positive_regulation GLP1R PDX1 18544709 706246 Positive_regulation GLP1R PIK3CA 19151742 6834 Positive_regulation GLP1R PIK3R1 19151742 6835 Positive_regulation GLP1R PRKACB 24148218 510373 Positive_regulation GLP1R PRKACG 24148218 510374 Positive_regulation GLP1R PRKAR1A 24148218 510375 Positive_regulation GLP1R PRKAR1B 24148218 510376 Positive_regulation GLP1R PRKAR2A 24148218 510377 Positive_regulation GLP1R PRKAR2B 24148218 510378 Positive_regulation GLP1R SLC33A1 24592256 880188 Positive_regulation GLP1R TCF12 24302978 2887166 Positive_regulation GLP1R TCF15 24302978 2887167 Positive_regulation GLP1R TCF19 24302978 2887168 Positive_regulation GLP1R TCF20 24302978 2887169 Positive_regulation GLP1R TCF21 24302978 2887170 Positive_regulation GLP1R TCF23 24302978 2887174 Positive_regulation GLP1R TCF24 24302978 2887176 Positive_regulation GLP1R TCF25 24302978 2887175 Positive_regulation GLP1R TCF3 24302978 2887171 Positive_regulation GLP1R TCF4 24302978 2887172 Positive_regulation GLP1R TCF7 24302978 2887173 Positive_regulation GLP1R ZGLP1 19861722 1167094 Positive_regulation GLP1R ZGLP1 21251280 508373 Positive_regulation GLP1R ZGLP1 21744074 733472 Positive_regulation GLP1R ZGLP1 21935440 2555811 Positive_regulation GLP1R ZGLP1 22111033 730308 Positive_regulation GLP1R ZGLP1 22120969 14049 Positive_regulation GLP1R ZGLP1 22120969 14064 Positive_regulation GLP1R ZGLP1 22132774 508644 Positive_regulation GLP1R ZGLP1 22649424 875801 Positive_regulation GLP1R ZGLP1 22754566 1073201 Positive_regulation GLP1R ZGLP1 22780564 2119352 Positive_regulation GLP1R ZGLP1 22885388 1619931 Positive_regulation GLP1R ZGLP1 23209191 725186 Positive_regulation GLP1R ZGLP1 23284795 2731007 Positive_regulation GLP1R ZGLP1 23469279 2763660 Positive_regulation GLP1R ZGLP1 23737653 1753223 Positive_regulation GLP1R ZGLP1 24195794 221010 Positive_regulation GLP1R ZGLP1 24307763 1755502 Positive_regulation GLP1R ZGLP1 24327600 787519 Positive_regulation GLP1R ZGLP1 24587221 2929082 Positive_regulation GLP1R ZGLP1 24795698 880568 Positive_regulation GLP1R ZGLP1 24843641 1494202 Positive_regulation GLP1R ZGLP1 PMC4033979 2245948 Positive_regulation GLS EPHB2 21085672 2482926 Positive_regulation GLS TNF 22534375 125571 Positive_regulation GLS TNF 22534375 125572 Positive_regulation GLS TNF 22534375 125581 Positive_regulation GLS TNF 22534375 125583 Positive_regulation GLS TNF 22534375 125586 Positive_regulation GLS TNF 22534375 125588 Positive_regulation GLS TNF 22534375 125590 Positive_regulation GLS TNF 22655214 1052862 Positive_regulation GLS TNF 22919405 636865 Positive_regulation GLS TNF 23493580 3175279 Positive_regulation GLTSCR2 TCN1 9126921 1601059 Positive_regulation GLYCAM1 TNF 22880094 2674207 Positive_regulation GNAI3 TNF 24751948 2956183 Positive_regulation GNB1 RGS2 23755177 2801645 Positive_regulation GNB2L1 TNF 24007266 1667013 Positive_regulation GNG10 FAS 22676303 1724672 Positive_regulation GNG10 PGC 22590537 2641176 Positive_regulation GNG11 FAS 22676303 1724673 Positive_regulation GNG11 PGC 22590537 2641177 Positive_regulation GNG12 FAS 22676303 1724670 Positive_regulation GNG12 PGC 22590537 2641173 Positive_regulation GNG13 FAS 22676303 1724669 Positive_regulation GNG13 PGC 22590537 2641172 Positive_regulation GNG2 FAS 22676303 1724674 Positive_regulation GNG2 PGC 22590537 2641178 Positive_regulation GNG2 RGS2 23755177 2801646 Positive_regulation GNG3 FAS 22676303 1724675 Positive_regulation GNG3 PGC 22590537 2641179 Positive_regulation GNG4 FAS 22676303 1724676 Positive_regulation GNG4 PGC 22590537 2641180 Positive_regulation GNG5 FAS 22676303 1724677 Positive_regulation GNG5 PGC 22590537 2641181 Positive_regulation GNG7 FAS 22676303 1724678 Positive_regulation GNG7 PGC 22590537 2641182 Positive_regulation GNG8 FAS 22676303 1724671 Positive_regulation GNG8 PGC 22590537 2641174 Positive_regulation GNRH1 FAS 24622841 3081738 Positive_regulation GNRHR EPHB2 23248618 877649 Positive_regulation GOLGA2 EPHB2 11425867 1271712 Positive_regulation GORASP1 EPHB2 18762583 1357044 Positive_regulation GORASP1 EPHB2 18762583 1357047 Positive_regulation GORASP1 EPHB2 24312472 2889518 Positive_regulation GORASP1 MAP2K6 18762583 1357054 Positive_regulation GORASP1 TNF 19893201 736357 Positive_regulation GORASP2 EPHB2 21152094 2486254 Positive_regulation GOT1 SYNM 24250714 824186 Positive_regulation GOT2 SYNM 24250714 824187 Positive_regulation GP2 IL1B 23286246 2111797 Positive_regulation GP2 ITGAL 16445864 3096156 Positive_regulation GP2 ITGB2 16445864 3096157 Positive_regulation GP2 ITGB2 2564418 1577415 Positive_regulation GP2 MMP28 25117565 2996641 Positive_regulation GP2 MMP7 25117565 2996656 Positive_regulation GP2 TNF 19434244 646161 Positive_regulation GP2 TNF 22837985 940960 Positive_regulation GP2 TNF 23853427 1754072 Positive_regulation GP5 IL1B 23286246 2111799 Positive_regulation GP5 ITGAL 16445864 3096158 Positive_regulation GP5 ITGB2 16445864 3096159 Positive_regulation GP5 ITGB2 2564418 1577417 Positive_regulation GP5 MMP28 25117565 2996663 Positive_regulation GP5 MMP7 25117565 2996678 Positive_regulation GP5 TNF 19434244 646163 Positive_regulation GP5 TNF 22837985 940962 Positive_regulation GP5 TNF 23853427 1754074 Positive_regulation GP6 F2R 23986721 962061 Positive_regulation GP6 IL1B 23286246 2111795 Positive_regulation GP6 ITGAL 16445864 3096154 Positive_regulation GP6 ITGB2 16445864 3096155 Positive_regulation GP6 ITGB2 2564418 1577413 Positive_regulation GP6 MMP28 25117565 2996619 Positive_regulation GP6 MMP7 25117565 2996634 Positive_regulation GP6 TNF 19434244 646159 Positive_regulation GP6 TNF 22837985 940958 Positive_regulation GP6 TNF 23853427 1754070 Positive_regulation GP9 IL1B 23286246 2111801 Positive_regulation GP9 ITGAL 16445864 3096160 Positive_regulation GP9 ITGB2 16445864 3096161 Positive_regulation GP9 ITGB2 2564418 1577419 Positive_regulation GP9 MMP28 25117565 2996685 Positive_regulation GP9 MMP7 25117565 2996700 Positive_regulation GP9 TNF 19434244 646165 Positive_regulation GP9 TNF 22837985 940964 Positive_regulation GP9 TNF 23853427 1754076 Positive_regulation GPBAR1 TNF 24755711 2957311 Positive_regulation GPBAR1 TNF 24755711 2957325 Positive_regulation GPBAR1 TNF 24755711 2957332 Positive_regulation GPER1 CCND1 24474947 879900 Positive_regulation GPER1 CCND1 24481325 787951 Positive_regulation GPER1 CTGF 24481325 787952 Positive_regulation GPHA2 GPR115 22984600 2689413 Positive_regulation GPHA2 GPR132 22984600 2689402 Positive_regulation GPHA2 GPR87 22984600 2689482 Positive_regulation GPHN CAPN8 24782709 869163 Positive_regulation GPHN EPHB2 24782709 869150 Positive_regulation GPI CA12 12451049 1607388 Positive_regulation GPI EPHB2 24385109 1880235 Positive_regulation GPI HES2 18218122 308332 Positive_regulation GPI MAP2K6 23531147 1725699 Positive_regulation GPI PTGIS 23520554 2769098 Positive_regulation GPI SLC9A2 20011065 1213388 Positive_regulation GPI SLCO2A1 25152926 3157056 Positive_regulation GPI TNF 18534002 110953 Positive_regulation GPI TNF 20193084 1727969 Positive_regulation GPI TNF 22131998 1703262 Positive_regulation GPI TNF 23755184 2801847 Positive_regulation GPNMB EDN1 23884103 220661 Positive_regulation GPNMB EDN1 23884103 220667 Positive_regulation GPNMB FLCN 21209915 2492399 Positive_regulation GPNMB FLCN 21209915 2492445 Positive_regulation GPNMB IFNG 23251410 2728576 Positive_regulation GPNMB MITF 22912767 2679215 Positive_regulation GPNMB MITF 22912767 2679231 Positive_regulation GPNMB TCF12 21635717 122679 Positive_regulation GPNMB TCF12 22912767 2679204 Positive_regulation GPNMB TCF15 21635717 122680 Positive_regulation GPNMB TCF15 22912767 2679205 Positive_regulation GPNMB TCF19 21635717 122681 Positive_regulation GPNMB TCF19 22912767 2679206 Positive_regulation GPNMB TCF20 21635717 122682 Positive_regulation GPNMB TCF20 22912767 2679207 Positive_regulation GPNMB TCF21 21635717 122683 Positive_regulation GPNMB TCF21 22912767 2679208 Positive_regulation GPNMB TCF23 21635717 122687 Positive_regulation GPNMB TCF23 22912767 2679212 Positive_regulation GPNMB TCF24 21635717 122689 Positive_regulation GPNMB TCF24 22912767 2679214 Positive_regulation GPNMB TCF25 21635717 122688 Positive_regulation GPNMB TCF25 22912767 2679213 Positive_regulation GPNMB TCF3 21635717 122684 Positive_regulation GPNMB TCF3 22912767 2679209 Positive_regulation GPNMB TCF4 21635717 122685 Positive_regulation GPNMB TCF4 22912767 2679210 Positive_regulation GPNMB TCF7 21635717 122686 Positive_regulation GPNMB TCF7 22912767 2679211 Positive_regulation GPNMB TFE3 21209915 2492397 Positive_regulation GPNMB TFE3 21209915 2492398 Positive_regulation GPNMB TFE3 21209915 2492425 Positive_regulation GPNMB TFE3 21209915 2492444 Positive_regulation GPR1 EPHB2 20162012 1089713 Positive_regulation GPR1 FOXO1 22933111 724367 Positive_regulation GPR1 ITGAL 10620605 1513894 Positive_regulation GPR1 TNF 22570668 634897 Positive_regulation GPR101 EPHB2 20162012 1089399 Positive_regulation GPR101 FOXO1 22933111 724323 Positive_regulation GPR101 ITGAL 10620605 1513850 Positive_regulation GPR101 TNF 22570668 634760 Positive_regulation GPR107 EPHB2 20162012 1089434 Positive_regulation GPR107 FOXO1 22933111 724328 Positive_regulation GPR107 ITGAL 10620605 1513855 Positive_regulation GPR107 TNF 22570668 634765 Positive_regulation GPR108 EPHB2 20162012 1089427 Positive_regulation GPR108 FOXO1 22933111 724327 Positive_regulation GPR108 ITGAL 10620605 1513854 Positive_regulation GPR108 TNF 22570668 634764 Positive_regulation GPR110 EPHB2 20162012 1089469 Positive_regulation GPR110 FOXO1 22933111 724333 Positive_regulation GPR110 ITGAL 10620605 1513860 Positive_regulation GPR110 TNF 22570668 634770 Positive_regulation GPR111 EPHB2 20162012 1089476 Positive_regulation GPR111 FOXO1 22933111 724334 Positive_regulation GPR111 ITGAL 10620605 1513861 Positive_regulation GPR111 TNF 22570668 634771 Positive_regulation GPR112 EPHB2 20162012 1089483 Positive_regulation GPR112 FOXO1 22933111 724335 Positive_regulation GPR112 ITGAL 10620605 1513862 Positive_regulation GPR112 TNF 22570668 634772 Positive_regulation GPR113 EPHB2 20162012 1089462 Positive_regulation GPR113 FOXO1 22933111 724332 Positive_regulation GPR113 GPR115 23009096 313660 Positive_regulation GPR113 ITGAL 10620605 1513859 Positive_regulation GPR113 TNF 22570668 634769 Positive_regulation GPR114 EPHB2 20162012 1089490 Positive_regulation GPR114 FOXO1 22933111 724336 Positive_regulation GPR114 ITGAL 10620605 1513863 Positive_regulation GPR114 TNF 22570668 634773 Positive_regulation GPR115 ACE 21927577 1057761 Positive_regulation GPR115 AKT1 20093365 1168709 Positive_regulation GPR115 AKT2 20093365 1168710 Positive_regulation GPR115 AKT3 20093365 1168711 Positive_regulation GPR115 C3 21589858 2523048 Positive_regulation GPR115 C5 25170421 247332 Positive_regulation GPR115 C5AR1 PMC2874285 35039 Positive_regulation GPR115 CA2 18454189 2388245 Positive_regulation GPR115 CA2 23887203 144418 Positive_regulation GPR115 CALCA 22936925 877022 Positive_regulation GPR115 EGF 24339877 2891742 Positive_regulation GPR115 EGFR 23451083 2757533 Positive_regulation GPR115 EPHB2 20162012 1089497 Positive_regulation GPR115 ESAM 22464650 624670 Positive_regulation GPR115 FOXO1 22933111 724337 Positive_regulation GPR115 GNAT1 20162012 1089498 Positive_regulation GPR115 GNAT2 20162012 1089499 Positive_regulation GPR115 GNAT3 20162012 1089496 Positive_regulation GPR115 GNB1 23242998 1810222 Positive_regulation GPR115 GNG2 23242998 1810223 Positive_regulation GPR115 GNRH1 20585619 2291393 Positive_regulation GPR115 HRAS 20162012 1089500 Positive_regulation GPR115 IGFBP5 23483937 2764765 Positive_regulation GPR115 IL1A 23900079 1034273 Positive_regulation GPR115 ITGAL 10620605 1513864 Positive_regulation GPR115 KRAS 20162012 1089501 Positive_regulation GPR115 LHCGR 24061539 1905113 Positive_regulation GPR115 LPA 22065949 928297 Positive_regulation GPR115 LPA 22065949 928485 Positive_regulation GPR115 LPA 25313141 2205166 Positive_regulation GPR115 MAP3K7 22590573 2642078 Positive_regulation GPR115 MAPK3 19575782 283295 Positive_regulation GPR115 MBTPS1 22065949 928296 Positive_regulation GPR115 MBTPS1 22065949 928484 Positive_regulation GPR115 MOCOS 24466442 1654097 Positive_regulation GPR115 MTOR 25295009 966072 Positive_regulation GPR115 NPS 20535358 1653647 Positive_regulation GPR115 NPS 22216302 2585397 Positive_regulation GPR115 NPS 24915894 3211557 Positive_regulation GPR115 NRAS 20162012 1089502 Positive_regulation GPR115 PARK10 24339877 2891740 Positive_regulation GPR115 PARK11 24339877 2891741 Positive_regulation GPR115 PARK12 24339877 2891743 Positive_regulation GPR115 PARK16 24339877 2891744 Positive_regulation GPR115 PARK2 24339877 2891745 Positive_regulation GPR115 PARK3 24339877 2891746 Positive_regulation GPR115 PARK7 24339877 2891739 Positive_regulation GPR115 PGF 17760987 3096499 Positive_regulation GPR115 PLD1 24995811 1765041 Positive_regulation GPR115 PLD2 24995811 1765042 Positive_regulation GPR115 PLD3 24995811 1765037 Positive_regulation GPR115 PLD4 24995811 1765038 Positive_regulation GPR115 PLD5 24995811 1765039 Positive_regulation GPR115 PLD6 24995811 1765040 Positive_regulation GPR115 RAB4A 24785348 619802 Positive_regulation GPR115 RASGRF1 11134081 1266204 Positive_regulation GPR115 RASGRF2 11134081 1266205 Positive_regulation GPR115 RGS5 17315600 3208198 Positive_regulation GPR115 RIC8A 19432969 362103 Positive_regulation GPR115 SRC 23887203 144417 Positive_regulation GPR115 STAT3 24995504 504824 Positive_regulation GPR115 TNF 22570668 634774 Positive_regulation GPR115 TRIB1 12537564 995134 Positive_regulation GPR115 VEGFA 17726541 2377842 Positive_regulation GPR115 VEGFA 22464650 624669 Positive_regulation GPR115 VEGFA 24339877 2891738 Positive_regulation GPR115 WAS 22529814 951593 Positive_regulation GPR115 ZGLP1 24148218 510401 Positive_regulation GPR115 ZGLP1 25325271 788415 Positive_regulation GPR116 EPHB2 20162012 1089504 Positive_regulation GPR116 FOXO1 22933111 724338 Positive_regulation GPR116 ITGAL 10620605 1513865 Positive_regulation GPR116 TNF 22570668 634775 Positive_regulation GPR119 EPHB2 20162012 1089511 Positive_regulation GPR119 FOXO1 22933111 724339 Positive_regulation GPR119 ITGAL 10620605 1513866 Positive_regulation GPR119 TNF 22570668 634776 Positive_regulation GPR12 EPHB2 20162012 1089720 Positive_regulation GPR12 FOXO1 22933111 724368 Positive_regulation GPR12 ITGAL 10620605 1513895 Positive_regulation GPR12 TNF 22570668 634898 Positive_regulation GPR123 EPHB2 20162012 1089378 Positive_regulation GPR123 FOXO1 22933111 724320 Positive_regulation GPR123 ITGAL 10620605 1513847 Positive_regulation GPR123 TNF 22570668 634757 Positive_regulation GPR124 EPHB2 20162012 1089441 Positive_regulation GPR124 FOXO1 22933111 724329 Positive_regulation GPR124 ITGAL 10620605 1513856 Positive_regulation GPR124 TNF 22570668 634766 Positive_regulation GPR125 EPHB2 20162012 1089385 Positive_regulation GPR125 FOXO1 22933111 724321 Positive_regulation GPR125 ITGAL 10620605 1513848 Positive_regulation GPR125 TNF 22570668 634758 Positive_regulation GPR126 EPHB2 20162012 1089392 Positive_regulation GPR126 FOXO1 22933111 724322 Positive_regulation GPR126 ITGAL 10620605 1513849 Positive_regulation GPR126 TNF 22570668 634759 Positive_regulation GPR128 EPHB2 20162012 1089518 Positive_regulation GPR128 FOXO1 22933111 724340 Positive_regulation GPR128 ITGAL 10620605 1513867 Positive_regulation GPR128 TNF 22570668 634777 Positive_regulation GPR132 ACE 21927577 1057750 Positive_regulation GPR132 AKT1 20093365 1168676 Positive_regulation GPR132 AKT2 20093365 1168677 Positive_regulation GPR132 AKT3 20093365 1168678 Positive_regulation GPR132 C3 21589858 2523037 Positive_regulation GPR132 C5 25170421 247321 Positive_regulation GPR132 C5AR1 PMC2874285 35028 Positive_regulation GPR132 CA2 18454189 2388234 Positive_regulation GPR132 CA2 23887203 144396 Positive_regulation GPR132 CALCA 22936925 877011 Positive_regulation GPR132 CDC123 21966461 2558977 Positive_regulation GPR132 CDC16 21966461 2558978 Positive_regulation GPR132 CDC20 21966461 2558979 Positive_regulation GPR132 CDC23 21966461 2558980 Positive_regulation GPR132 CDC26 21966461 2558989 Positive_regulation GPR132 CDC27 21966461 2558981 Positive_regulation GPR132 CDC34 21966461 2558982 Positive_regulation GPR132 CDC37 21966461 2558983 Positive_regulation GPR132 CDC40 21966461 2558984 Positive_regulation GPR132 CDC42 21966461 2558985 Positive_regulation GPR132 CDC45 21966461 2558986 Positive_regulation GPR132 CDC6 21966461 2558987 Positive_regulation GPR132 CDC7 21966461 2558988 Positive_regulation GPR132 CDC73 21966461 2558976 Positive_regulation GPR132 EGF 24339877 2891643 Positive_regulation GPR132 EGFR 23451083 2757522 Positive_regulation GPR132 EPHB2 20162012 1089420 Positive_regulation GPR132 ESAM 22464650 624648 Positive_regulation GPR132 FOXO1 22933111 724326 Positive_regulation GPR132 GNAT1 20162012 1089421 Positive_regulation GPR132 GNAT2 20162012 1089422 Positive_regulation GPR132 GNAT3 20162012 1089419 Positive_regulation GPR132 GNB1 23242998 1810200 Positive_regulation GPR132 GNG2 23242998 1810201 Positive_regulation GPR132 GNRH1 20585619 2291382 Positive_regulation GPR132 HRAS 20162012 1089423 Positive_regulation GPR132 IGFBP5 23483937 2764754 Positive_regulation GPR132 IL1A 23900079 1034262 Positive_regulation GPR132 ITGAL 10620605 1513853 Positive_regulation GPR132 KRAS 20162012 1089424 Positive_regulation GPR132 LHCGR 24061539 1905102 Positive_regulation GPR132 LPA 22065949 928275 Positive_regulation GPR132 LPA 22065949 928463 Positive_regulation GPR132 LPA 25313141 2205155 Positive_regulation GPR132 MAP3K7 22590573 2642066 Positive_regulation GPR132 MAPK3 19575782 283284 Positive_regulation GPR132 MBTPS1 22065949 928274 Positive_regulation GPR132 MBTPS1 22065949 928462 Positive_regulation GPR132 MOCOS 24466442 1654086 Positive_regulation GPR132 MTOR 25295009 966061 Positive_regulation GPR132 NPS 20535358 1653636 Positive_regulation GPR132 NPS 22216302 2585386 Positive_regulation GPR132 NPS 24915894 3211546 Positive_regulation GPR132 NRAS 20162012 1089425 Positive_regulation GPR132 PARK10 24339877 2891641 Positive_regulation GPR132 PARK11 24339877 2891642 Positive_regulation GPR132 PARK12 24339877 2891644 Positive_regulation GPR132 PARK16 24339877 2891645 Positive_regulation GPR132 PARK2 24339877 2891646 Positive_regulation GPR132 PARK3 24339877 2891647 Positive_regulation GPR132 PARK7 24339877 2891640 Positive_regulation GPR132 PGF 17760987 3096488 Positive_regulation GPR132 PLD1 24995811 1764975 Positive_regulation GPR132 PLD2 24995811 1764976 Positive_regulation GPR132 PLD3 24995811 1764971 Positive_regulation GPR132 PLD4 24995811 1764972 Positive_regulation GPR132 PLD5 24995811 1764973 Positive_regulation GPR132 PLD6 24995811 1764974 Positive_regulation GPR132 RAB4A 24785348 619791 Positive_regulation GPR132 RASGRF1 11134081 1266182 Positive_regulation GPR132 RASGRF2 11134081 1266183 Positive_regulation GPR132 RGS5 17315600 3208187 Positive_regulation GPR132 RIC8A 19432969 362092 Positive_regulation GPR132 SRC 23887203 144395 Positive_regulation GPR132 STAT3 24995504 504813 Positive_regulation GPR132 TNF 22570668 634763 Positive_regulation GPR132 TRIB1 12537564 995123 Positive_regulation GPR132 VEGFA 17726541 2377831 Positive_regulation GPR132 VEGFA 22464650 624647 Positive_regulation GPR132 VEGFA 24339877 2891639 Positive_regulation GPR132 WAS 22529814 951582 Positive_regulation GPR132 ZGLP1 24148218 510390 Positive_regulation GPR132 ZGLP1 25325271 788404 Positive_regulation GPR133 EPHB2 20162012 1089525 Positive_regulation GPR133 FOXO1 22933111 724341 Positive_regulation GPR133 ITGAL 10620605 1513868 Positive_regulation GPR133 TNF 22570668 634778 Positive_regulation GPR135 EPHB2 20162012 1089532 Positive_regulation GPR135 FOXO1 22933111 724342 Positive_regulation GPR135 ITGAL 10620605 1513869 Positive_regulation GPR135 TNF 22570668 634779 Positive_regulation GPR137 EPHB2 20162012 1089658 Positive_regulation GPR137 FOXO1 22933111 724360 Positive_regulation GPR137 ITGAL 10620605 1513887 Positive_regulation GPR137 TNF 22570668 634797 Positive_regulation GPR139 EPHB2 20162012 1089539 Positive_regulation GPR139 FOXO1 22933111 724343 Positive_regulation GPR139 ITGAL 10620605 1513870 Positive_regulation GPR139 TNF 22570668 634780 Positive_regulation GPR141 EPHB2 20162012 1089546 Positive_regulation GPR141 FOXO1 22933111 724344 Positive_regulation GPR141 ITGAL 10620605 1513871 Positive_regulation GPR141 TNF 22570668 634781 Positive_regulation GPR142 EPHB2 20162012 1089553 Positive_regulation GPR142 FOXO1 22933111 724345 Positive_regulation GPR142 ITGAL 10620605 1513872 Positive_regulation GPR142 TNF 22570668 634782 Positive_regulation GPR143 EPHB2 20162012 1089560 Positive_regulation GPR143 FOXO1 22933111 724346 Positive_regulation GPR143 ITGAL 10620605 1513873 Positive_regulation GPR143 TNF 22570668 634783 Positive_regulation GPR144 EPHB2 20162012 1089455 Positive_regulation GPR144 FOXO1 22933111 724331 Positive_regulation GPR144 ITGAL 10620605 1513858 Positive_regulation GPR144 TNF 22570668 634768 Positive_regulation GPR146 EPHB2 20162012 1089574 Positive_regulation GPR146 FOXO1 22933111 724348 Positive_regulation GPR146 ITGAL 10620605 1513875 Positive_regulation GPR146 TNF 22570668 634785 Positive_regulation GPR148 EPHB2 20162012 1089602 Positive_regulation GPR148 FOXO1 22933111 724352 Positive_regulation GPR148 ITGAL 10620605 1513879 Positive_regulation GPR148 TNF 22570668 634789 Positive_regulation GPR149 EPHB2 20162012 1089616 Positive_regulation GPR149 FOXO1 22933111 724354 Positive_regulation GPR149 ITGAL 10620605 1513881 Positive_regulation GPR149 TNF 22570668 634791 Positive_regulation GPR15 EPHB2 20162012 1089727 Positive_regulation GPR15 FOXO1 22933111 724369 Positive_regulation GPR15 ITGAL 10620605 1513896 Positive_regulation GPR15 TNF 22570668 634899 Positive_regulation GPR150 EPHB2 20162012 1089623 Positive_regulation GPR150 FOXO1 22933111 724355 Positive_regulation GPR150 ITGAL 10620605 1513882 Positive_regulation GPR150 TNF 22570668 634792 Positive_regulation GPR151 EPHB2 20162012 1089609 Positive_regulation GPR151 FOXO1 22933111 724353 Positive_regulation GPR151 ITGAL 10620605 1513880 Positive_regulation GPR151 TNF 22570668 634790 Positive_regulation GPR152 EPHB2 20162012 1089595 Positive_regulation GPR152 FOXO1 22933111 724351 Positive_regulation GPR152 ITGAL 10620605 1513878 Positive_regulation GPR152 TNF 22570668 634788 Positive_regulation GPR153 EPHB2 20162012 1089588 Positive_regulation GPR153 FOXO1 22933111 724350 Positive_regulation GPR153 ITGAL 10620605 1513877 Positive_regulation GPR153 TNF 22570668 634787 Positive_regulation GPR155 EPHB2 20162012 1089581 Positive_regulation GPR155 FOXO1 22933111 724349 Positive_regulation GPR155 ITGAL 10620605 1513876 Positive_regulation GPR155 TNF 22570668 634786 Positive_regulation GPR156 EPHB2 20162012 1089567 Positive_regulation GPR156 FOXO1 22933111 724347 Positive_regulation GPR156 ITGAL 10620605 1513874 Positive_regulation GPR156 TNF 22570668 634784 Positive_regulation GPR157 EPHB2 20162012 1089630 Positive_regulation GPR157 FOXO1 22933111 724356 Positive_regulation GPR157 ITGAL 10620605 1513883 Positive_regulation GPR157 TNF 22570668 634793 Positive_regulation GPR158 EPHB2 20162012 1089637 Positive_regulation GPR158 FOXO1 22933111 724357 Positive_regulation GPR158 ITGAL 10620605 1513884 Positive_regulation GPR158 TNF 22570668 634794 Positive_regulation GPR160 EPHB2 20162012 1089644 Positive_regulation GPR160 FOXO1 22933111 724358 Positive_regulation GPR160 ITGAL 10620605 1513885 Positive_regulation GPR160 TNF 22570668 634795 Positive_regulation GPR161 EPHB2 20162012 1089651 Positive_regulation GPR161 FOXO1 22933111 724359 Positive_regulation GPR161 ITGAL 10620605 1513886 Positive_regulation GPR161 TNF 22570668 634796 Positive_regulation GPR162 EPHB2 20162012 1089406 Positive_regulation GPR162 FOXO1 22933111 724324 Positive_regulation GPR162 ITGAL 10620605 1513851 Positive_regulation GPR162 TNF 22570668 634761 Positive_regulation GPR17 EPHB2 20162012 1089734 Positive_regulation GPR17 FOXO1 22933111 724370 Positive_regulation GPR17 ITGAL 10620605 1513897 Positive_regulation GPR17 TNF 22570668 634900 Positive_regulation GPR171 EPHB2 20162012 1089672 Positive_regulation GPR171 FOXO1 22933111 724362 Positive_regulation GPR171 ITGAL 10620605 1513889 Positive_regulation GPR171 TNF 22570668 634892 Positive_regulation GPR173 EPHB2 20162012 1089448 Positive_regulation GPR173 FOXO1 22933111 724330 Positive_regulation GPR173 ITGAL 10620605 1513857 Positive_regulation GPR173 TNF 22570668 634767 Positive_regulation GPR174 EPHB2 20162012 1089679 Positive_regulation GPR174 FOXO1 22933111 724363 Positive_regulation GPR174 ITGAL 10620605 1513890 Positive_regulation GPR174 TNF 22570668 634893 Positive_regulation GPR176 EPHB2 20162012 1089700 Positive_regulation GPR176 FOXO1 22933111 724366 Positive_regulation GPR176 ITGAL 10620605 1513893 Positive_regulation GPR176 TNF 22570668 634896 Positive_regulation GPR179 EPHB2 20162012 1089693 Positive_regulation GPR179 FOXO1 22933111 724365 Positive_regulation GPR179 ITGAL 10620605 1513892 Positive_regulation GPR179 TNF 22570668 634895 Positive_regulation GPR18 EPHB2 20162012 1089741 Positive_regulation GPR18 FOXO1 22933111 724371 Positive_regulation GPR18 ITGAL 10620605 1513898 Positive_regulation GPR18 TNF 22570668 634901 Positive_regulation GPR180 EPHB2 20162012 1089665 Positive_regulation GPR180 FOXO1 22933111 724361 Positive_regulation GPR180 ITGAL 10620605 1513888 Positive_regulation GPR180 TNF 22570668 634891 Positive_regulation GPR182 EPHB2 20162012 1089364 Positive_regulation GPR182 FOXO1 22933111 724318 Positive_regulation GPR182 ITGAL 10620605 1513845 Positive_regulation GPR182 TNF 22570668 634755 Positive_regulation GPR183 EPHB2 20162012 1089686 Positive_regulation GPR183 FOXO1 22933111 724364 Positive_regulation GPR183 ITGAL 10620605 1513891 Positive_regulation GPR183 TNF 22570668 634894 Positive_regulation GPR19 EPHB2 20162012 1089748 Positive_regulation GPR19 FOXO1 22933111 724372 Positive_regulation GPR19 ITGAL 10620605 1513899 Positive_regulation GPR19 TNF 22570668 634902 Positive_regulation GPR20 EPHB2 20162012 1089755 Positive_regulation GPR20 FOXO1 22933111 724373 Positive_regulation GPR20 ITGAL 10620605 1513900 Positive_regulation GPR20 TNF 22570668 634903 Positive_regulation GPR21 EPHB2 20162012 1089762 Positive_regulation GPR21 FOXO1 22933111 724374 Positive_regulation GPR21 ITGAL 10620605 1513901 Positive_regulation GPR21 TNF 22570668 634904 Positive_regulation GPR22 EPHB2 20162012 1089769 Positive_regulation GPR22 FOXO1 22933111 724375 Positive_regulation GPR22 ITGAL 10620605 1513902 Positive_regulation GPR22 TNF 22570668 634905 Positive_regulation GPR25 EPHB2 20162012 1089776 Positive_regulation GPR25 FOXO1 22933111 724376 Positive_regulation GPR25 ITGAL 10620605 1513903 Positive_regulation GPR25 TNF 22570668 634906 Positive_regulation GPR26 EPHB2 20162012 1089783 Positive_regulation GPR26 FOXO1 22933111 724377 Positive_regulation GPR26 ITGAL 10620605 1513904 Positive_regulation GPR26 TNF 22570668 634907 Positive_regulation GPR27 EPHB2 20162012 1089790 Positive_regulation GPR27 FOXO1 22933111 724378 Positive_regulation GPR27 ITGAL 10620605 1513905 Positive_regulation GPR27 TNF 22570668 634908 Positive_regulation GPR3 EPHB2 20162012 1089797 Positive_regulation GPR3 FOXO1 22933111 724379 Positive_regulation GPR3 ITGAL 10620605 1513906 Positive_regulation GPR3 TNF 22570668 634909 Positive_regulation GPR31 EPHB2 20162012 1089804 Positive_regulation GPR31 FOXO1 22933111 724380 Positive_regulation GPR31 ITGAL 10620605 1513907 Positive_regulation GPR31 TNF 22570668 634910 Positive_regulation GPR32 EPHB2 20162012 1089811 Positive_regulation GPR32 FOXO1 22933111 724381 Positive_regulation GPR32 ITGAL 10620605 1513908 Positive_regulation GPR32 TNF 22570668 634911 Positive_regulation GPR33 EPHB2 20162012 1089818 Positive_regulation GPR33 FOXO1 22933111 724382 Positive_regulation GPR33 ITGAL 10620605 1513909 Positive_regulation GPR33 TNF 22570668 634912 Positive_regulation GPR34 EPHB2 20162012 1089825 Positive_regulation GPR34 FOXO1 22933111 724383 Positive_regulation GPR34 ITGAL 10620605 1513910 Positive_regulation GPR34 TNF 22570668 634913 Positive_regulation GPR35 EPHB2 20162012 1089832 Positive_regulation GPR35 FOXO1 22933111 724384 Positive_regulation GPR35 ITGAL 10620605 1513911 Positive_regulation GPR35 TNF 22570668 634914 Positive_regulation GPR36 EPHB2 20162012 1089839 Positive_regulation GPR36 FOXO1 22933111 724385 Positive_regulation GPR36 ITGAL 10620605 1513912 Positive_regulation GPR36 TNF 22570668 634915 Positive_regulation GPR37 EPHB2 20162012 1089846 Positive_regulation GPR37 EPHB2 24244600 2880559 Positive_regulation GPR37 FOXO1 22933111 724386 Positive_regulation GPR37 ITGAL 10620605 1513913 Positive_regulation GPR37 TNF 22570668 634916 Positive_regulation GPR37L1 EPHB2 24244600 2880556 Positive_regulation GPR39 EPHB2 20162012 1089853 Positive_regulation GPR39 FOXO1 22933111 724387 Positive_regulation GPR39 ITGAL 10620605 1513914 Positive_regulation GPR39 TNF 22570668 634917 Positive_regulation GPR4 EPHB2 20162012 1089860 Positive_regulation GPR4 FOXO1 22933111 724388 Positive_regulation GPR4 ITGAL 10620605 1513915 Positive_regulation GPR4 TNF 22570668 634918 Positive_regulation GPR42 EPHB2 20162012 1089867 Positive_regulation GPR42 FOXO1 22933111 724389 Positive_regulation GPR42 ITGAL 10620605 1513916 Positive_regulation GPR42 TNF 22570668 634919 Positive_regulation GPR45 EPHB2 20162012 1089874 Positive_regulation GPR45 FOXO1 22933111 724390 Positive_regulation GPR45 ITGAL 10620605 1513917 Positive_regulation GPR45 TNF 22570668 634920 Positive_regulation GPR50 EPHB2 20162012 1089881 Positive_regulation GPR50 FOXO1 22933111 724391 Positive_regulation GPR50 ITGAL 10620605 1513918 Positive_regulation GPR50 TNF 22570668 634921 Positive_regulation GPR52 EPHB2 20162012 1089888 Positive_regulation GPR52 FOXO1 22933111 724392 Positive_regulation GPR52 ITGAL 10620605 1513919 Positive_regulation GPR52 TNF 22570668 634922 Positive_regulation GPR55 EPHB2 20162012 1089895 Positive_regulation GPR55 FOXO1 22933111 724393 Positive_regulation GPR55 ITGAL 10620605 1513920 Positive_regulation GPR55 TNF 22570668 634923 Positive_regulation GPR56 EPHB2 20162012 1089902 Positive_regulation GPR56 FOXO1 22933111 724394 Positive_regulation GPR56 ITGAL 10620605 1513921 Positive_regulation GPR56 TNF 22570668 634924 Positive_regulation GPR6 EPHB2 20162012 1089909 Positive_regulation GPR6 FOXO1 22933111 724395 Positive_regulation GPR6 ITGAL 10620605 1513922 Positive_regulation GPR6 TNF 22570668 634925 Positive_regulation GPR61 EPHB2 20162012 1089343 Positive_regulation GPR61 FOXO1 22933111 724315 Positive_regulation GPR61 ITGAL 10620605 1513842 Positive_regulation GPR61 TNF 22570668 634752 Positive_regulation GPR62 EPHB2 20162012 1089350 Positive_regulation GPR62 FOXO1 22933111 724316 Positive_regulation GPR62 ITGAL 10620605 1513843 Positive_regulation GPR62 TNF 22570668 634753 Positive_regulation GPR63 EPHB2 20162012 1089357 Positive_regulation GPR63 FOXO1 22933111 724317 Positive_regulation GPR63 ITGAL 10620605 1513844 Positive_regulation GPR63 TNF 22570668 634754 Positive_regulation GPR64 EPHB2 20162012 1089916 Positive_regulation GPR64 FOXO1 22933111 724396 Positive_regulation GPR64 ITGAL 10620605 1513923 Positive_regulation GPR64 TNF 22570668 634926 Positive_regulation GPR65 EPHB2 20162012 1089923 Positive_regulation GPR65 FOXO1 22933111 724397 Positive_regulation GPR65 ITGAL 10620605 1513924 Positive_regulation GPR65 TNF 22570668 634927 Positive_regulation GPR68 CTGF 24244587 2880492 Positive_regulation GPR68 EPHB2 20162012 1089930 Positive_regulation GPR68 FOXO1 22933111 724398 Positive_regulation GPR68 ITGAL 10620605 1513925 Positive_regulation GPR68 MUC16 25197168 1762012 Positive_regulation GPR68 TNF 22570668 634928 Positive_regulation GPR75 EPHB2 20162012 1089944 Positive_regulation GPR75 FOXO1 22933111 724400 Positive_regulation GPR75 ITGAL 10620605 1513927 Positive_regulation GPR75 TNF 22570668 634930 Positive_regulation GPR78 EPHB2 20162012 1089951 Positive_regulation GPR78 FOXO1 22933111 724401 Positive_regulation GPR78 ITGAL 10620605 1513928 Positive_regulation GPR78 TNF 22570668 634931 Positive_regulation GPR79 EPHB2 20162012 1089958 Positive_regulation GPR79 FOXO1 22933111 724402 Positive_regulation GPR79 ITGAL 10620605 1513929 Positive_regulation GPR79 TNF 22570668 634932 Positive_regulation GPR82 EPHB2 20162012 1089965 Positive_regulation GPR82 FOXO1 22933111 724403 Positive_regulation GPR82 ITGAL 10620605 1513930 Positive_regulation GPR82 TNF 22570668 634933 Positive_regulation GPR83 EPHB2 20162012 1089937 Positive_regulation GPR83 FOXO1 22933111 724399 Positive_regulation GPR83 ITGAL 10620605 1513926 Positive_regulation GPR83 TNF 22570668 634929 Positive_regulation GPR84 EPHB2 20162012 1089972 Positive_regulation GPR84 FOXO1 22933111 724404 Positive_regulation GPR84 ITGAL 10620605 1513931 Positive_regulation GPR84 TNF 22570668 634934 Positive_regulation GPR84 TNF 24828675 2970000 Positive_regulation GPR85 EPHB2 20162012 1089979 Positive_regulation GPR85 FOXO1 22933111 724405 Positive_regulation GPR85 ITGAL 10620605 1513932 Positive_regulation GPR85 TNF 22570668 634935 Positive_regulation GPR87 ACE 21927577 1057830 Positive_regulation GPR87 AKT1 20093365 1168952 Positive_regulation GPR87 AKT2 20093365 1168953 Positive_regulation GPR87 AKT3 20093365 1168954 Positive_regulation GPR87 C3 21589858 2523117 Positive_regulation GPR87 C5 25170421 247401 Positive_regulation GPR87 C5AR1 PMC2874285 35108 Positive_regulation GPR87 CA2 18454189 2388314 Positive_regulation GPR87 CA2 23887203 144556 Positive_regulation GPR87 CALCA 22936925 877091 Positive_regulation GPR87 EGF 24339877 2892388 Positive_regulation GPR87 EGFR 23451083 2757718 Positive_regulation GPR87 EPHB2 20162012 1089986 Positive_regulation GPR87 ESAM 22464650 624808 Positive_regulation GPR87 FOXO1 22933111 724406 Positive_regulation GPR87 GNAT1 20162012 1089987 Positive_regulation GPR87 GNAT2 20162012 1089988 Positive_regulation GPR87 GNAT3 20162012 1089985 Positive_regulation GPR87 GNB1 23242998 1810360 Positive_regulation GPR87 GNG2 23242998 1810361 Positive_regulation GPR87 GNRH1 20585619 2291462 Positive_regulation GPR87 HRAS 20162012 1089989 Positive_regulation GPR87 IGFBP5 23483937 2764860 Positive_regulation GPR87 IL1A 23900079 1034342 Positive_regulation GPR87 ITGAL 10620605 1513933 Positive_regulation GPR87 KRAS 20162012 1089990 Positive_regulation GPR87 LHCGR 24061539 1905182 Positive_regulation GPR87 LPA 22065949 928435 Positive_regulation GPR87 LPA 22065949 928624 Positive_regulation GPR87 LPA 25313141 2205235 Positive_regulation GPR87 MAP3K7 22590573 2642150 Positive_regulation GPR87 MAPK3 19575782 283364 Positive_regulation GPR87 MBTPS1 22065949 928434 Positive_regulation GPR87 MBTPS1 22065949 928623 Positive_regulation GPR87 MOCOS 24466442 1654166 Positive_regulation GPR87 MTOR 25295009 966142 Positive_regulation GPR87 NPS 20535358 1653716 Positive_regulation GPR87 NPS 22216302 2585467 Positive_regulation GPR87 NPS 24915894 3211626 Positive_regulation GPR87 NRAS 20162012 1089991 Positive_regulation GPR87 PARK10 24339877 2892386 Positive_regulation GPR87 PARK11 24339877 2892387 Positive_regulation GPR87 PARK12 24339877 2892389 Positive_regulation GPR87 PARK16 24339877 2892390 Positive_regulation GPR87 PARK2 24339877 2892391 Positive_regulation GPR87 PARK3 24339877 2892392 Positive_regulation GPR87 PARK7 24339877 2892385 Positive_regulation GPR87 PGF 17760987 3096568 Positive_regulation GPR87 PLD1 24995811 1765734 Positive_regulation GPR87 PLD2 24995811 1765735 Positive_regulation GPR87 PLD3 24995811 1765730 Positive_regulation GPR87 PLD4 24995811 1765731 Positive_regulation GPR87 PLD5 24995811 1765732 Positive_regulation GPR87 PLD6 24995811 1765733 Positive_regulation GPR87 RAB4A 24785348 619871 Positive_regulation GPR87 RASGRF1 11134081 1266342 Positive_regulation GPR87 RASGRF2 11134081 1266343 Positive_regulation GPR87 RGS5 17315600 3208267 Positive_regulation GPR87 RIC8A 19432969 362172 Positive_regulation GPR87 SRC 23887203 144555 Positive_regulation GPR87 STAT3 24995504 504893 Positive_regulation GPR87 TNF 22570668 634936 Positive_regulation GPR87 TRIB1 12537564 995203 Positive_regulation GPR87 VEGFA 17726541 2377911 Positive_regulation GPR87 VEGFA 22464650 624807 Positive_regulation GPR87 VEGFA 24339877 2892384 Positive_regulation GPR87 WAS 22529814 951662 Positive_regulation GPR87 ZGLP1 24148218 510470 Positive_regulation GPR87 ZGLP1 25325271 788484 Positive_regulation GPR88 EPHB2 20162012 1089993 Positive_regulation GPR88 FOXO1 22933111 724407 Positive_regulation GPR88 ITGAL 10620605 1513934 Positive_regulation GPR88 TNF 22570668 634937 Positive_regulation GPR97 EPHB2 20162012 1089371 Positive_regulation GPR97 FOXO1 22933111 724319 Positive_regulation GPR97 ITGAL 10620605 1513846 Positive_regulation GPR97 TNF 22570668 634756 Positive_regulation GPR98 EPHB2 20162012 1089413 Positive_regulation GPR98 FOXO1 22933111 724325 Positive_regulation GPR98 ITGAL 10620605 1513852 Positive_regulation GPR98 TNF 22570668 634762 Positive_regulation GPS2 PGC 23304112 3076121 Positive_regulation GPX1 FOXO1 20716932 2222673 Positive_regulation GPX1 PGC 22563483 2626875 Positive_regulation GPX1 PGC 25071841 896347 Positive_regulation GPX1 SRGN 24238102 1870262 Positive_regulation GPX1 TNF 23300968 2737750 Positive_regulation GPX2 FOXO1 20716932 2222675 Positive_regulation GPX2 PGC 22563483 2626876 Positive_regulation GPX2 PGC 25071841 896348 Positive_regulation GPX2 TNF 23300968 2737751 Positive_regulation GPX3 FOXO1 20716932 2222677 Positive_regulation GPX3 PGC 22563483 2626877 Positive_regulation GPX3 PGC 25071841 896349 Positive_regulation GPX3 TNF 23300968 2737752 Positive_regulation GPX4 FOXO1 20716932 2222679 Positive_regulation GPX4 PGC 22563483 2626878 Positive_regulation GPX4 PGC 25071841 896350 Positive_regulation GPX4 TNF 23300968 2737753 Positive_regulation GPX5 FOXO1 20716932 2222681 Positive_regulation GPX5 PGC 22563483 2626879 Positive_regulation GPX5 PGC 25071841 896351 Positive_regulation GPX5 TNF 23300968 2737754 Positive_regulation GPX6 FOXO1 20716932 2222683 Positive_regulation GPX6 PGC 22563483 2626880 Positive_regulation GPX6 PGC 25071841 896352 Positive_regulation GPX6 TNF 23300968 2737755 Positive_regulation GPX7 FOXO1 20716932 2222685 Positive_regulation GPX7 PGC 22563483 2626881 Positive_regulation GPX7 PGC 25071841 896353 Positive_regulation GPX7 TNF 23300968 2737756 Positive_regulation GPX8 FOXO1 20716932 2222670 Positive_regulation GPX8 PGC 22563483 2626874 Positive_regulation GPX8 PGC 25071841 896346 Positive_regulation GPX8 TNF 23300968 2737749 Positive_regulation GRAP2 CHI3L1 22056877 2144453 Positive_regulation GRAP2 EPHB2 20111592 2438462 Positive_regulation GRAP2 EPHB2 21048967 2480296 Positive_regulation GRAP2 EPHB2 22114704 2573498 Positive_regulation GRAP2 EPHB2 24727794 2951722 Positive_regulation GRAP2 FAS 9362518 1464801 Positive_regulation GRAP2 ID1 18489764 352169 Positive_regulation GRAP2 MAP2K6 10330402 1246196 Positive_regulation GRAP2 MAP2K6 20026657 1369843 Positive_regulation GRAP2 MAP2K6 20955562 120641 Positive_regulation GRAP2 MAP2K6 21829386 2325918 Positive_regulation GRAP2 MAP2K6 22175015 1686880 Positive_regulation GRAP2 MAP2K6 22569127 771783 Positive_regulation GRAP2 MAP2K6 22870983 288901 Positive_regulation GRAP2 MAP2K6 24526913 3155953 Positive_regulation GRAP2 S100B 22227007 2008241 Positive_regulation GRAP2 TNF 10385526 1247198 Positive_regulation GRAP2 TNF 15642133 102085 Positive_regulation GRAP2 TNF 16207331 104365 Positive_regulation GRAP2 TNF 20070884 1852902 Positive_regulation GRAP2 TNF 20615213 119593 Positive_regulation GRAP2 TNF 21386087 718511 Positive_regulation GRAP2 TNF 23468959 2760294 Positive_regulation GRAP2 TNF 23626383 1046743 Positive_regulation GRAP2 TNF 24098801 2864935 Positive_regulation GRAP2 TNF 24223057 824097 Positive_regulation GRAP2 TNF 24352036 1632444 Positive_regulation GRAP2 TNF 24489443 1757401 Positive_regulation GRAP2 TNF 24743742 573941 Positive_regulation GRAP2 TNFSF10 22462553 1230484 Positive_regulation GRB10 F2R 22952817 2684161 Positive_regulation GRB14 F2R 22952817 2684162 Positive_regulation GRB2 EPHB2 18404483 3087922 Positive_regulation GRB2 EPHB2 24142503 2185076 Positive_regulation GRB2 EPHB2 24709879 617256 Positive_regulation GRB2 EPHB2 24957684 2232035 Positive_regulation GRB2 F2R 22952817 2684163 Positive_regulation GRB2 MAP2K6 18404483 3087928 Positive_regulation GRB2 MAP2K6 24709879 617262 Positive_regulation GRB7 F2R 22952817 2684164 Positive_regulation GREB1 FOXA1 21878914 1904080 Positive_regulation GRHL2 WNT7A 23284647 2730367 Positive_regulation GRHL2 WNT7A 23284647 2730375 Positive_regulation GRHL2 WNT7A 23284647 2730376 Positive_regulation GRIA1 MMP28 24853857 2973035 Positive_regulation GRIA1 MMP28 24853857 2973057 Positive_regulation GRIA1 MMP28 24853857 2973123 Positive_regulation GRIA1 MMP7 24853857 2973050 Positive_regulation GRIA1 MMP7 24853857 2973072 Positive_regulation GRIA1 MMP7 24853857 2973138 Positive_regulation GRIA1 NES 23749147 1968427 Positive_regulation GRIK2 CA2 23556457 3187402 Positive_regulation GRIK2 CUL3 25141211 1766253 Positive_regulation GRIK2 FASLG 23949220 564816 Positive_regulation GRIK2 HSPG2 23556457 3187403 Positive_regulation GRIK2 KLHL13 25141211 1766251 Positive_regulation GRIK2 KLHL17 25141211 1766252 Positive_regulation GRIK2 KLHL9 25141211 1766250 Positive_regulation GRIK2 NETO2 23236500 2726724 Positive_regulation GRIK2 PTS 23556457 3187407 Positive_regulation GRIK2 RAB11A 23556457 3187400 Positive_regulation GRIK2 RAB11A 23556457 3187408 Positive_regulation GRIK2 RAB17 24895134 1209558 Positive_regulation GRIK2 RAB17 24895134 1209559 Positive_regulation GRIK2 RAB17 24895134 1209560 Positive_regulation GRIK2 RAB17 24895134 1209569 Positive_regulation GRIK2 RAB17 24895134 1209571 Positive_regulation GRIK2 RAB17 24895134 1209572 Positive_regulation GRIK2 STX4 24895134 1209556 Positive_regulation GRIK2 STX4 24895134 1209557 Positive_regulation GRIN2A EPHB2 20661302 2456583 Positive_regulation GRIN2B CAPN8 19529798 2419472 Positive_regulation GRIN2B CAPN8 25393018 3025387 Positive_regulation GRIN2B EPHB2 20661302 2456584 Positive_regulation GRIN2B EPHB2 23050197 2232557 Positive_regulation GRIN2B EPHB2 23341972 2741515 Positive_regulation GRK1 EPHB2 23977191 2838877 Positive_regulation GRK1 F2R 21760880 2535578 Positive_regulation GRK1 F2R 21760880 2535813 Positive_regulation GRK4 EPHB2 23977191 2838884 Positive_regulation GRK4 F2R 21760880 2535659 Positive_regulation GRK4 F2R 21760880 2535829 Positive_regulation GRK5 EPHB2 23977191 2838885 Positive_regulation GRK5 F2R 21760880 2535677 Positive_regulation GRK5 F2R 21760880 2535834 Positive_regulation GRK6 EPHB2 23977191 2838886 Positive_regulation GRK6 F2R 21760880 2535695 Positive_regulation GRK6 F2R 21760880 2535839 Positive_regulation GRK7 EPHB2 23977191 2838878 Positive_regulation GRK7 F2R 21760880 2535608 Positive_regulation GRK7 F2R 21760880 2535823 Positive_regulation GRM1 EPHB2 22347189 950761 Positive_regulation GRM2 TNF 24768662 3102640 Positive_regulation GRM5 EPHB2 22347189 950763 Positive_regulation GRN JAG1 19015152 2037579 Positive_regulation GRN STK39 22860019 2671137 Positive_regulation GRN TLR7 23239020 1890364 Positive_regulation GRN TNF 21863317 1644769 Positive_regulation GSK3B WNT7A 24287629 1939685 Positive_regulation GSPT1 CCND1 21955753 260967 Positive_regulation GSPT1 CCND1 23383245 2749735 Positive_regulation GSPT1 EPHB2 22235328 2585825 Positive_regulation GSPT1 ID1 25028095 1875724 Positive_regulation GSPT1 ID1 25028095 1875725 Positive_regulation GSPT1 ID1 25028095 1875726 Positive_regulation GSPT1 ID1 25028095 1875727 Positive_regulation GSPT1 ID1 25028095 1875728 Positive_regulation GSPT1 ID1 25028095 1875750 Positive_regulation GSPT1 ID1 25028095 1875758 Positive_regulation GSPT1 ID1 25028095 1875791 Positive_regulation GSPT1 ID1 25028095 1875798 Positive_regulation GSPT1 ID1 25028095 1875812 Positive_regulation GSPT2 CCND1 21955753 260968 Positive_regulation GSPT2 CCND1 23383245 2749736 Positive_regulation GSPT2 EPHB2 22235328 2585826 Positive_regulation GSTA4 EPHB2 22207314 30164 Positive_regulation GTF2B FOLR1 20485488 2271771 Positive_regulation GTF2B ITGB2 24047317 3122253 Positive_regulation GTF2B PGC 17389765 3071451 Positive_regulation GTF2B TNF 21298084 2321000 Positive_regulation GTF2B TNF 22904091 2080652 Positive_regulation GTF2B TNF 8666922 1597189 Positive_regulation GTF2F1 PGC 17389765 3071452 Positive_regulation GTF2F1 TNF 21298084 2321001 Positive_regulation GTF2F2 PGC 17389765 3071453 Positive_regulation GTF2F2 TNF 21298084 2321002 Positive_regulation GUCY2D S100B 24723847 931611 Positive_regulation GUCY2D S100B 24723847 931614 Positive_regulation GUCY2D S100B 24723847 931617 Positive_regulation GUCY2D S100B 24808824 931816 Positive_regulation GUCY2D S100B 25071437 932103 Positive_regulation GUCY2D S100B 25071437 932110 Positive_regulation GUCY2D S100B 25071437 932111 Positive_regulation GYS1 EDN2 24523730 3077098 Positive_regulation GYS1 EPHB2 24841081 2971504 Positive_regulation GYS1 S100B 23533154 178291 Positive_regulation GYS2 EDN2 24523730 3077101 Positive_regulation GYS2 EPHB2 24841081 2971510 Positive_regulation GYS2 S100B 23533154 178292 Positive_regulation GZMB CAPN8 9314540 1463946 Positive_regulation GZMB MAP2K6 24795729 912642 Positive_regulation GZMB TNF 23483844 863987 Positive_regulation GZMB TNF 24638205 3223803 Positive_regulation H1F0 CCND1 21347341 3051194 Positive_regulation H2AFX TNFSF10 21092294 1860277 Positive_regulation HAAO TNF 24979620 2985651 Positive_regulation HAL ZFP57 21695267 2530111 Positive_regulation HAMP TF 20066043 21499 Positive_regulation HAMP TF 20631898 21561 Positive_regulation HAMP TF 20631898 21571 Positive_regulation HAMP TF 21283739 2497544 Positive_regulation HAMP TF 21978626 2112942 Positive_regulation HAMP TF 24236640 450692 Positive_regulation HAMP TF 24616700 953631 Positive_regulation HAMP TNF 18625622 90745 Positive_regulation HAMP TNF 22998440 1231262 Positive_regulation HAMP TNF 23028567 2691359 Positive_regulation HAMP TNF 24286116 130134 Positive_regulation HAS1 EPHB2 24704994 806955 Positive_regulation HAS2 PLAU 24023701 2843340 Positive_regulation HAS3 EGF 21429221 1861121 Positive_regulation HAS3 EGF 21429221 1861124 Positive_regulation HAS3 EGF 21429221 1861126 Positive_regulation HAS3 EGF 21429221 1861127 Positive_regulation HAS3 ERBB2 21429221 1861125 Positive_regulation HAS3 IL1A 20619343 1731744 Positive_regulation HAS3 IL1A 20619343 1731754 Positive_regulation HAS3 IL1A 21263749 806629 Positive_regulation HAS3 IL1A 21263749 806630 Positive_regulation HAS3 IL1A 21263749 806631 Positive_regulation HAS3 IL1A 21263749 806632 Positive_regulation HAUS2 NES 15251038 277780 Positive_regulation HAVCR2 TLR7 24339828 910245 Positive_regulation HAVCR2 TNF 23213314 1039531 Positive_regulation HAVCR2 TNF 23450201 906147 Positive_regulation HAVCR2 TNF 24289479 1667388 Positive_regulation HBD IL1B 22438960 2612193 Positive_regulation HBD MAP2K6 20634980 2455809 Positive_regulation HBD SPHK1 20634980 2455675 Positive_regulation HBD SPHK1 20634980 2455676 Positive_regulation HBD SPHK1 20634980 2455677 Positive_regulation HBD SPHK1 20634980 2455704 Positive_regulation HBD SPHK1 20634980 2455724 Positive_regulation HBD SPHK1 20634980 2455780 Positive_regulation HBD TLR7 20634980 2455686 Positive_regulation HBD TNF 16219107 3105715 Positive_regulation HBD TNF 20182640 631854 Positive_regulation HBD TNF 23649937 161221 Positive_regulation HBD TNF 23762096 637764 Positive_regulation HBEGF ADAM10 12927027 457936 Positive_regulation HBEGF ADAM10 21179550 2489155 Positive_regulation HBEGF ADAM10 22754566 1073192 Positive_regulation HBEGF ADAM10 23888518 3185268 Positive_regulation HBEGF ADAM10 25261977 1510627 Positive_regulation HBEGF ADAM10 25261977 1510628 Positive_regulation HBEGF ADAM10 25261977 1510788 Positive_regulation HBEGF ADAM11 21179550 2489156 Positive_regulation HBEGF ADAM11 23888518 3185269 Positive_regulation HBEGF ADAM11 25261977 1510629 Positive_regulation HBEGF ADAM11 25261977 1510630 Positive_regulation HBEGF ADAM11 25261977 1510789 Positive_regulation HBEGF ADAM12 21179550 2489157 Positive_regulation HBEGF ADAM12 23451083 2757560 Positive_regulation HBEGF ADAM12 23589494 1404530 Positive_regulation HBEGF ADAM12 23888518 3185270 Positive_regulation HBEGF ADAM12 25261977 1510631 Positive_regulation HBEGF ADAM12 25261977 1510632 Positive_regulation HBEGF ADAM12 25261977 1510790 Positive_regulation HBEGF ADAM15 14993236 1306906 Positive_regulation HBEGF ADAM15 21179550 2489158 Positive_regulation HBEGF ADAM15 23888518 3185271 Positive_regulation HBEGF ADAM15 25261977 1510633 Positive_regulation HBEGF ADAM15 25261977 1510634 Positive_regulation HBEGF ADAM15 25261977 1510791 Positive_regulation HBEGF ADAM17 21179550 2489159 Positive_regulation HBEGF ADAM17 21386996 2506132 Positive_regulation HBEGF ADAM17 21386996 2506134 Positive_regulation HBEGF ADAM17 23888518 3185272 Positive_regulation HBEGF ADAM17 25232008 1830858 Positive_regulation HBEGF ADAM17 25261977 1510635 Positive_regulation HBEGF ADAM17 25261977 1510636 Positive_regulation HBEGF ADAM17 25261977 1510792 Positive_regulation HBEGF ADAM17 25285155 857003 Positive_regulation HBEGF ADAM17 25384035 3024636 Positive_regulation HBEGF ADAM18 21179550 2489160 Positive_regulation HBEGF ADAM18 23888518 3185273 Positive_regulation HBEGF ADAM18 25261977 1510637 Positive_regulation HBEGF ADAM18 25261977 1510638 Positive_regulation HBEGF ADAM18 25261977 1510793 Positive_regulation HBEGF ADAM19 21179550 2489161 Positive_regulation HBEGF ADAM19 23888518 3185274 Positive_regulation HBEGF ADAM19 25261977 1510639 Positive_regulation HBEGF ADAM19 25261977 1510640 Positive_regulation HBEGF ADAM19 25261977 1510794 Positive_regulation HBEGF ADAM2 21179550 2489162 Positive_regulation HBEGF ADAM2 23888518 3185275 Positive_regulation HBEGF ADAM2 25261977 1510641 Positive_regulation HBEGF ADAM2 25261977 1510642 Positive_regulation HBEGF ADAM2 25261977 1510795 Positive_regulation HBEGF ADAM20 21179550 2489163 Positive_regulation HBEGF ADAM20 23888518 3185276 Positive_regulation HBEGF ADAM20 25261977 1510643 Positive_regulation HBEGF ADAM20 25261977 1510644 Positive_regulation HBEGF ADAM20 25261977 1510796 Positive_regulation HBEGF ADAM21 21179550 2489164 Positive_regulation HBEGF ADAM21 23888518 3185277 Positive_regulation HBEGF ADAM21 25261977 1510645 Positive_regulation HBEGF ADAM21 25261977 1510646 Positive_regulation HBEGF ADAM21 25261977 1510797 Positive_regulation HBEGF ADAM22 21179550 2489165 Positive_regulation HBEGF ADAM22 23888518 3185278 Positive_regulation HBEGF ADAM22 25261977 1510647 Positive_regulation HBEGF ADAM22 25261977 1510648 Positive_regulation HBEGF ADAM22 25261977 1510798 Positive_regulation HBEGF ADAM23 21179550 2489166 Positive_regulation HBEGF ADAM23 23888518 3185279 Positive_regulation HBEGF ADAM23 25261977 1510649 Positive_regulation HBEGF ADAM23 25261977 1510650 Positive_regulation HBEGF ADAM23 25261977 1510799 Positive_regulation HBEGF ADAM28 21179550 2489167 Positive_regulation HBEGF ADAM28 23888518 3185280 Positive_regulation HBEGF ADAM28 25261977 1510651 Positive_regulation HBEGF ADAM28 25261977 1510652 Positive_regulation HBEGF ADAM28 25261977 1510800 Positive_regulation HBEGF ADAM29 21179550 2489168 Positive_regulation HBEGF ADAM29 23888518 3185281 Positive_regulation HBEGF ADAM29 25261977 1510653 Positive_regulation HBEGF ADAM29 25261977 1510654 Positive_regulation HBEGF ADAM29 25261977 1510801 Positive_regulation HBEGF ADAM30 21179550 2489169 Positive_regulation HBEGF ADAM30 23888518 3185282 Positive_regulation HBEGF ADAM30 25261977 1510655 Positive_regulation HBEGF ADAM30 25261977 1510656 Positive_regulation HBEGF ADAM30 25261977 1510802 Positive_regulation HBEGF ADAM32 21179550 2489154 Positive_regulation HBEGF ADAM32 23888518 3185267 Positive_regulation HBEGF ADAM32 25261977 1510625 Positive_regulation HBEGF ADAM32 25261977 1510626 Positive_regulation HBEGF ADAM32 25261977 1510787 Positive_regulation HBEGF ADAM33 21179550 2489153 Positive_regulation HBEGF ADAM33 23888518 3185266 Positive_regulation HBEGF ADAM33 25261977 1510623 Positive_regulation HBEGF ADAM33 25261977 1510624 Positive_regulation HBEGF ADAM33 25261977 1510786 Positive_regulation HBEGF ADAM5 21179550 2489170 Positive_regulation HBEGF ADAM5 23888518 3185283 Positive_regulation HBEGF ADAM5 25261977 1510657 Positive_regulation HBEGF ADAM5 25261977 1510658 Positive_regulation HBEGF ADAM5 25261977 1510803 Positive_regulation HBEGF ADAM6 21179550 2489171 Positive_regulation HBEGF ADAM6 23888518 3185284 Positive_regulation HBEGF ADAM6 25261977 1510659 Positive_regulation HBEGF ADAM6 25261977 1510660 Positive_regulation HBEGF ADAM6 25261977 1510804 Positive_regulation HBEGF ADAM7 21179550 2489172 Positive_regulation HBEGF ADAM7 23888518 3185285 Positive_regulation HBEGF ADAM7 25261977 1510661 Positive_regulation HBEGF ADAM7 25261977 1510662 Positive_regulation HBEGF ADAM7 25261977 1510805 Positive_regulation HBEGF ADAM8 21179550 2489173 Positive_regulation HBEGF ADAM8 23888518 3185286 Positive_regulation HBEGF ADAM8 25261977 1510663 Positive_regulation HBEGF ADAM8 25261977 1510664 Positive_regulation HBEGF ADAM8 25261977 1510806 Positive_regulation HBEGF ADAM9 21179550 2489174 Positive_regulation HBEGF ADAM9 23888518 3185287 Positive_regulation HBEGF ADAM9 25261977 1510665 Positive_regulation HBEGF ADAM9 25261977 1510666 Positive_regulation HBEGF ADAM9 25261977 1510807 Positive_regulation HBEGF AKT1 24887420 2975889 Positive_regulation HBEGF AKT2 24887420 2975890 Positive_regulation HBEGF AKT3 24887420 2975891 Positive_regulation HBEGF ANXA6 22984591 2689367 Positive_regulation HBEGF BACE2 7876316 1442375 Positive_regulation HBEGF BACE2 7876316 1442379 Positive_regulation HBEGF BCL6 19337254 432033 Positive_regulation HBEGF BSN 20946648 1859870 Positive_regulation HBEGF CA2 25342939 685342 Positive_regulation HBEGF CAMP 20195469 2441899 Positive_regulation HBEGF CCK 20584780 1023286 Positive_regulation HBEGF CCND2 19337254 432034 Positive_regulation HBEGF CD44 17177600 2368921 Positive_regulation HBEGF CD44 21687519 950350 Positive_regulation HBEGF CD9 7876316 1442374 Positive_regulation HBEGF CD9 7876316 1442378 Positive_regulation HBEGF CDC73 25261977 1510737 Positive_regulation HBEGF CDC73 25261977 1510781 Positive_regulation HBEGF COL1A1 22984591 2689362 Positive_regulation HBEGF COL1A2 22984591 2689363 Positive_regulation HBEGF CSF2 20946648 1859854 Positive_regulation HBEGF CSF2 20946648 1859866 Positive_regulation HBEGF CSF2 20946648 1859867 Positive_regulation HBEGF CSF2 20946648 1859871 Positive_regulation HBEGF CSF2 20946648 1859875 Positive_regulation HBEGF CSF2 23888518 3185321 Positive_regulation HBEGF CSF2 23888518 3185330 Positive_regulation HBEGF CSF2 25033458 2990302 Positive_regulation HBEGF CTR9 25261977 1510738 Positive_regulation HBEGF CTR9 25261977 1510782 Positive_regulation HBEGF CXCL12 20946648 1859849 Positive_regulation HBEGF CXCL12 20946648 1859850 Positive_regulation HBEGF CXCL12 20946648 1859865 Positive_regulation HBEGF CXCL12 20946648 1859874 Positive_regulation HBEGF CXCL12 20946648 1859876 Positive_regulation HBEGF CXCL12 20946648 1859877 Positive_regulation HBEGF CXCL12 20946648 1859880 Positive_regulation HBEGF CXCL12 23888518 3185320 Positive_regulation HBEGF DEFB4B 20195469 2441900 Positive_regulation HBEGF EDN1 20452970 1187721 Positive_regulation HBEGF EDN1 20452970 1187741 Positive_regulation HBEGF EDN1 20452970 1187768 Positive_regulation HBEGF EGF 14597776 1299860 Positive_regulation HBEGF EGF 22852097 1154752 Positive_regulation HBEGF EGF 23029355 2696792 Positive_regulation HBEGF EGF 23391100 342726 Positive_regulation HBEGF EGF 23472148 2764229 Positive_regulation HBEGF EGF 25102001 1766131 Positive_regulation HBEGF EGF 25364759 862476 Positive_regulation HBEGF EGFR 23342005 2741603 Positive_regulation HBEGF EGFR 23451083 2757724 Positive_regulation HBEGF EGFR 23589494 1404531 Positive_regulation HBEGF EGFR 23589494 1404558 Positive_regulation HBEGF EGFR 23760291 1709467 Positive_regulation HBEGF EGFR 23888518 3185315 Positive_regulation HBEGF EGFR 23888518 3185822 Positive_regulation HBEGF EGFR 24952482 2192853 Positive_regulation HBEGF EGFR 25033458 2990298 Positive_regulation HBEGF EGFR 25232008 1830859 Positive_regulation HBEGF EGFR 25232008 1830861 Positive_regulation HBEGF EGFR 25356505 1133561 Positive_regulation HBEGF EGFR 25356505 1133620 Positive_regulation HBEGF EGFR 25437333 2234084 Positive_regulation HBEGF EGFR PMC3353448 35131 Positive_regulation HBEGF EGFR PMC3760629 1606182 Positive_regulation HBEGF EPHB2 22873932 533022 Positive_regulation HBEGF EPHB2 PMC3760629 1606183 Positive_regulation HBEGF F12 17177600 2368922 Positive_regulation HBEGF F2RL1 24009895 1605695 Positive_regulation HBEGF FUT1 22330337 1717966 Positive_regulation HBEGF GAST 20584780 1023266 Positive_regulation HBEGF GAST 20584780 1023281 Positive_regulation HBEGF GAST 25346875 2231110 Positive_regulation HBEGF GAST PMC2557557 450134 Positive_regulation HBEGF GPER1 24289103 474092 Positive_regulation HBEGF IFI44 24887420 2975887 Positive_regulation HBEGF IL1A 22911722 2675965 Positive_regulation HBEGF IL1A 22911722 2675966 Positive_regulation HBEGF IL1A 22911722 2675968 Positive_regulation HBEGF IL1A 22911722 2675970 Positive_regulation HBEGF IL1A 22911722 2675971 Positive_regulation HBEGF IL1A 22911722 2675974 Positive_regulation HBEGF INS 25060396 492926 Positive_regulation HBEGF ITGAX 22911108 3058809 Positive_regulation HBEGF JUN 25060396 492934 Positive_regulation HBEGF LEO1 25261977 1510741 Positive_regulation HBEGF LEO1 25261977 1510785 Positive_regulation HBEGF LEP 23792587 478975 Positive_regulation HBEGF LPA 20139904 9344 Positive_regulation HBEGF MAP2K1 22873932 533023 Positive_regulation HBEGF MAP2K1 25437333 2234085 Positive_regulation HBEGF MAP2K2 22873932 533024 Positive_regulation HBEGF MAP2K3 22873932 533025 Positive_regulation HBEGF MAP2K4 22873932 533026 Positive_regulation HBEGF MAP2K5 22873932 533027 Positive_regulation HBEGF MAP2K6 22873932 533028 Positive_regulation HBEGF MAP2K7 22873932 533029 Positive_regulation HBEGF MAPK1 15817123 1844556 Positive_regulation HBEGF MAPK1 15817123 1844633 Positive_regulation HBEGF MAPK1 PMC3760629 1606184 Positive_regulation HBEGF MAPK10 15817123 1844557 Positive_regulation HBEGF MAPK10 15817123 1844634 Positive_regulation HBEGF MAPK10 PMC3760629 1606185 Positive_regulation HBEGF MAPK11 15817123 1844558 Positive_regulation HBEGF MAPK11 15817123 1844635 Positive_regulation HBEGF MAPK11 PMC3760629 1606186 Positive_regulation HBEGF MAPK12 15817123 1844559 Positive_regulation HBEGF MAPK12 15817123 1844636 Positive_regulation HBEGF MAPK12 PMC3760629 1606187 Positive_regulation HBEGF MAPK13 15817123 1844560 Positive_regulation HBEGF MAPK13 15817123 1844637 Positive_regulation HBEGF MAPK13 PMC3760629 1606188 Positive_regulation HBEGF MAPK14 15817123 1844561 Positive_regulation HBEGF MAPK14 15817123 1844638 Positive_regulation HBEGF MAPK14 PMC3760629 1606189 Positive_regulation HBEGF MAPK15 15817123 1844555 Positive_regulation HBEGF MAPK15 15817123 1844632 Positive_regulation HBEGF MAPK15 PMC3760629 1606181 Positive_regulation HBEGF MAPK3 15817123 1844562 Positive_regulation HBEGF MAPK3 15817123 1844639 Positive_regulation HBEGF MAPK3 PMC3760629 1606190 Positive_regulation HBEGF MAPK4 15817123 1844563 Positive_regulation HBEGF MAPK4 15817123 1844640 Positive_regulation HBEGF MAPK4 PMC3760629 1606191 Positive_regulation HBEGF MAPK6 15817123 1844564 Positive_regulation HBEGF MAPK6 15817123 1844641 Positive_regulation HBEGF MAPK6 PMC3760629 1606192 Positive_regulation HBEGF MAPK7 15817123 1844565 Positive_regulation HBEGF MAPK7 15817123 1844642 Positive_regulation HBEGF MAPK7 PMC3760629 1606193 Positive_regulation HBEGF MAPK8 15817123 1844566 Positive_regulation HBEGF MAPK8 15817123 1844643 Positive_regulation HBEGF MAPK8 PMC3760629 1606194 Positive_regulation HBEGF MAPK9 15817123 1844567 Positive_regulation HBEGF MAPK9 15817123 1844644 Positive_regulation HBEGF MAPK9 PMC3760629 1606195 Positive_regulation HBEGF MMP1 17177600 2368934 Positive_regulation HBEGF MMP1 17177600 2368956 Positive_regulation HBEGF MMP1 21179550 2489175 Positive_regulation HBEGF MMP1 23213380 167835 Positive_regulation HBEGF MMP1 25261977 1510540 Positive_regulation HBEGF MMP10 17177600 2368935 Positive_regulation HBEGF MMP10 17177600 2368957 Positive_regulation HBEGF MMP10 21179550 2489176 Positive_regulation HBEGF MMP10 23213380 167836 Positive_regulation HBEGF MMP10 25261977 1510541 Positive_regulation HBEGF MMP11 17177600 2368936 Positive_regulation HBEGF MMP11 17177600 2368958 Positive_regulation HBEGF MMP11 21179550 2489177 Positive_regulation HBEGF MMP11 23213380 167837 Positive_regulation HBEGF MMP11 25261977 1510542 Positive_regulation HBEGF MMP12 17177600 2368937 Positive_regulation HBEGF MMP12 17177600 2368959 Positive_regulation HBEGF MMP12 21179550 2489178 Positive_regulation HBEGF MMP12 23213380 167838 Positive_regulation HBEGF MMP12 25261977 1510543 Positive_regulation HBEGF MMP13 17177600 2368938 Positive_regulation HBEGF MMP13 17177600 2368960 Positive_regulation HBEGF MMP13 21179550 2489179 Positive_regulation HBEGF MMP13 23213380 167839 Positive_regulation HBEGF MMP13 25261977 1510544 Positive_regulation HBEGF MMP14 17177600 2368939 Positive_regulation HBEGF MMP14 17177600 2368961 Positive_regulation HBEGF MMP14 18949075 2208051 Positive_regulation HBEGF MMP14 21179550 2489180 Positive_regulation HBEGF MMP14 23213380 167840 Positive_regulation HBEGF MMP14 25261977 1510545 Positive_regulation HBEGF MMP15 17177600 2368940 Positive_regulation HBEGF MMP15 17177600 2368962 Positive_regulation HBEGF MMP15 21179550 2489181 Positive_regulation HBEGF MMP15 23213380 167841 Positive_regulation HBEGF MMP15 25261977 1510546 Positive_regulation HBEGF MMP16 17177600 2368941 Positive_regulation HBEGF MMP16 17177600 2368963 Positive_regulation HBEGF MMP16 21179550 2489182 Positive_regulation HBEGF MMP16 23213380 167842 Positive_regulation HBEGF MMP16 25261977 1510547 Positive_regulation HBEGF MMP17 17177600 2368942 Positive_regulation HBEGF MMP17 17177600 2368964 Positive_regulation HBEGF MMP17 21179550 2489183 Positive_regulation HBEGF MMP17 23213380 167843 Positive_regulation HBEGF MMP17 25261977 1510548 Positive_regulation HBEGF MMP19 17177600 2368943 Positive_regulation HBEGF MMP19 17177600 2368965 Positive_regulation HBEGF MMP19 21179550 2489184 Positive_regulation HBEGF MMP19 23213380 167844 Positive_regulation HBEGF MMP19 25261977 1510549 Positive_regulation HBEGF MMP2 17177600 2368944 Positive_regulation HBEGF MMP2 17177600 2368966 Positive_regulation HBEGF MMP2 21179550 2489185 Positive_regulation HBEGF MMP2 23213380 167845 Positive_regulation HBEGF MMP2 24013225 2153508 Positive_regulation HBEGF MMP2 25261977 1510550 Positive_regulation HBEGF MMP20 17177600 2368945 Positive_regulation HBEGF MMP20 17177600 2368967 Positive_regulation HBEGF MMP20 21179550 2489186 Positive_regulation HBEGF MMP20 23213380 167846 Positive_regulation HBEGF MMP20 25261977 1510551 Positive_regulation HBEGF MMP21 17177600 2368932 Positive_regulation HBEGF MMP21 17177600 2368954 Positive_regulation HBEGF MMP21 21179550 2489151 Positive_regulation HBEGF MMP21 23213380 167833 Positive_regulation HBEGF MMP21 25261977 1510538 Positive_regulation HBEGF MMP24 17177600 2368946 Positive_regulation HBEGF MMP24 17177600 2368968 Positive_regulation HBEGF MMP24 21179550 2489187 Positive_regulation HBEGF MMP24 23213380 167847 Positive_regulation HBEGF MMP24 25261977 1510552 Positive_regulation HBEGF MMP25 17177600 2368929 Positive_regulation HBEGF MMP25 17177600 2368951 Positive_regulation HBEGF MMP25 21179550 2489148 Positive_regulation HBEGF MMP25 23213380 167830 Positive_regulation HBEGF MMP25 25261977 1510535 Positive_regulation HBEGF MMP26 17177600 2368930 Positive_regulation HBEGF MMP26 17177600 2368952 Positive_regulation HBEGF MMP26 21179550 2489149 Positive_regulation HBEGF MMP26 23213380 167831 Positive_regulation HBEGF MMP26 25261977 1510536 Positive_regulation HBEGF MMP27 17177600 2368931 Positive_regulation HBEGF MMP27 17177600 2368953 Positive_regulation HBEGF MMP27 21179550 2489150 Positive_regulation HBEGF MMP27 23213380 167832 Positive_regulation HBEGF MMP27 25261977 1510537 Positive_regulation HBEGF MMP28 17177600 2368933 Positive_regulation HBEGF MMP28 17177600 2368955 Positive_regulation HBEGF MMP28 21179550 2489152 Positive_regulation HBEGF MMP28 23213380 167834 Positive_regulation HBEGF MMP28 25261977 1510539 Positive_regulation HBEGF MMP3 17177600 2368947 Positive_regulation HBEGF MMP3 17177600 2368969 Positive_regulation HBEGF MMP3 21179550 2489188 Positive_regulation HBEGF MMP3 23213380 167848 Positive_regulation HBEGF MMP3 25261977 1510553 Positive_regulation HBEGF MMP7 17177600 2368948 Positive_regulation HBEGF MMP7 17177600 2368970 Positive_regulation HBEGF MMP7 20584780 1023267 Positive_regulation HBEGF MMP7 21179550 2489189 Positive_regulation HBEGF MMP7 23213380 167849 Positive_regulation HBEGF MMP7 25261977 1510554 Positive_regulation HBEGF MMP8 17177600 2368949 Positive_regulation HBEGF MMP8 17177600 2368971 Positive_regulation HBEGF MMP8 21179550 2489190 Positive_regulation HBEGF MMP8 23213380 167850 Positive_regulation HBEGF MMP8 25261977 1510555 Positive_regulation HBEGF MMP9 17177600 2368950 Positive_regulation HBEGF MMP9 17177600 2368972 Positive_regulation HBEGF MMP9 21179550 2489191 Positive_regulation HBEGF MMP9 23213380 167851 Positive_regulation HBEGF MMP9 24013225 2153509 Positive_regulation HBEGF MMP9 25261977 1510556 Positive_regulation HBEGF MST1 25186587 1768395 Positive_regulation HBEGF MTOR 22984591 2689364 Positive_regulation HBEGF MTOR 22984591 2689366 Positive_regulation HBEGF MYLIP 22319602 2595595 Positive_regulation HBEGF MYLIP 23437250 2756304 Positive_regulation HBEGF NGF 25510766 3233796 Positive_regulation HBEGF NOTCH1 25566499 949530 Positive_regulation HBEGF NOTCH2 25566499 949531 Positive_regulation HBEGF NOTCH3 25566499 949532 Positive_regulation HBEGF NOTCH4 25566499 949533 Positive_regulation HBEGF NTS 25249545 2201857 Positive_regulation HBEGF NUP43 24887420 2975888 Positive_regulation HBEGF OXA1L 22319602 2595596 Positive_regulation HBEGF PAF1 25261977 1510739 Positive_regulation HBEGF PAF1 25261977 1510783 Positive_regulation HBEGF PLAU 18599586 83815 Positive_regulation HBEGF PRB1 23029355 2696793 Positive_regulation HBEGF PRB2 23029355 2696794 Positive_regulation HBEGF PRB3 23029355 2696795 Positive_regulation HBEGF PRB4 23029355 2696796 Positive_regulation HBEGF PRL PMC4233545 477200 Positive_regulation HBEGF RALA 21179550 2489032 Positive_regulation HBEGF RSPO1 22157721 1717839 Positive_regulation HBEGF RUNX2 24136232 568202 Positive_regulation HBEGF RUNX2 24136232 568203 Positive_regulation HBEGF RUNX2 24136232 568204 Positive_regulation HBEGF RUNX2 24136232 568223 Positive_regulation HBEGF S100A6 23029355 2696791 Positive_regulation HBEGF SDC2 8349739 1447591 Positive_regulation HBEGF SLC39A6 22110740 2573135 Positive_regulation HBEGF SP1 25060396 492923 Positive_regulation HBEGF SP1 25060396 492925 Positive_regulation HBEGF SP1 25060396 492933 Positive_regulation HBEGF SRC 23209895 1689854 Positive_regulation HBEGF SRC 23213380 167783 Positive_regulation HBEGF SRC 23991110 2840949 Positive_regulation HBEGF SRC 25342939 685341 Positive_regulation HBEGF TP63 25186587 1768394 Positive_regulation HBEGF VEGFA 10188881 414122 Positive_regulation HBEGF WDR61 25261977 1510740 Positive_regulation HBEGF WDR61 25261977 1510784 Positive_regulation HBEGF WNT1 22157721 1717832 Positive_regulation HBEGF WNT11 22157721 1717833 Positive_regulation HBEGF WNT16 22157721 1717838 Positive_regulation HBEGF WNT2 22157721 1717834 Positive_regulation HBEGF WNT3 22157721 1717835 Positive_regulation HBEGF WNT4 22157721 1717836 Positive_regulation HBEGF WNT6 22157721 1717837 Positive_regulation HCCS CCND1 19402906 1503676 Positive_regulation HCG11 PTGER2 20705717 1885321 Positive_regulation HCG14 PTGER2 20705717 1885323 Positive_regulation HCG15 PTGER2 20705717 1885325 Positive_regulation HCG16 PTGER2 20705717 1885331 Positive_regulation HCG17 PTGER2 20705717 1885371 Positive_regulation HCG18 PTGER2 20705717 1885369 Positive_regulation HCG20 PTGER2 20705717 1885365 Positive_regulation HCG21 PTGER2 20705717 1885367 Positive_regulation HCG22 PTGER2 20705717 1885361 Positive_regulation HCG23 PTGER2 20705717 1885327 Positive_regulation HCG24 PTGER2 20705717 1885339 Positive_regulation HCG25 PTGER2 20705717 1885329 Positive_regulation HCG26 PTGER2 20705717 1885363 Positive_regulation HCG27 PTGER2 20705717 1885359 Positive_regulation HCG4 PTGER2 20705717 1885333 Positive_regulation HCG8 PTGER2 20705717 1885335 Positive_regulation HCG9 PTGER2 20705717 1885337 Positive_regulation HCLS1 CTGF 19214781 1478530 Positive_regulation HCLS1 NGFR 21904642 2223759 Positive_regulation HCLS1 NGFR 23880857 1109101 Positive_regulation HCLS1 TNF 19570027 137294 Positive_regulation HDAC1 EPHB2 16262446 2258789 Positive_regulation HDAC1 FOXO1 25329053 2365592 Positive_regulation HDAC1 NES 24552625 2013144 Positive_regulation HDAC1 PGC 22453831 1933608 Positive_regulation HDAC1 TNF 21234331 1218425 Positive_regulation HDAC1 TNF 24707477 188391 Positive_regulation HDAC1 TNF 24707477 188392 Positive_regulation HDAC1 TNF 7931061 1593055 Positive_regulation HDAC1 ZFP57 20808772 2472163 Positive_regulation HDAC2 EPHB2 16262446 2258790 Positive_regulation HDAC2 NES 24552625 2013153 Positive_regulation HDAC2 PGC 22453831 1933609 Positive_regulation HDAC2 TNF 21234331 1218427 Positive_regulation HDAC2 TNF 24707477 188393 Positive_regulation HDAC2 TNF 24707477 188394 Positive_regulation HDAC2 TNF 7931061 1593057 Positive_regulation HDAC2 ZFP57 20808772 2472181 Positive_regulation HDAC3 PGC 23304112 3076127 Positive_regulation HDAC3 RCAN1 25144594 3001109 Positive_regulation HDAC3 ZFP57 21173110 1383625 Positive_regulation HDAC4 FOXO1 22662228 2647528 Positive_regulation HDAC4 FOXO1 25357003 2367200 Positive_regulation HDAC6 NEDD9 19836940 686867 Positive_regulation HECTD3 TNFSF10 24287696 569430 Positive_regulation HES1 EPHB2 18950493 524939 Positive_regulation HES1 EPHB2 20652960 3170736 Positive_regulation HES1 FOXO1 20567496 1056167 Positive_regulation HES1 FOXO1 20567496 1056177 Positive_regulation HES1 JAG1 19839776 1236865 Positive_regulation HES1 JAG1 23704950 2797093 Positive_regulation HES1 JAG1 23773282 483502 Positive_regulation HES1 JAG1 24659709 2188439 Positive_regulation HES1 JAG1 24708907 6065 Positive_regulation HES1 MAML3 21716644 936393 Positive_regulation HES1 MAP2K6 24392017 2905172 Positive_regulation HES1 TNF 21242294 1562405 Positive_regulation HES1 TNF 22190977 633811 Positive_regulation HES1 TNF 22190977 633812 Positive_regulation HES1 TNF 22190977 633838 Positive_regulation HES1 TNF 22190977 633868 Positive_regulation HES1 TNF 23236394 2726159 Positive_regulation HES2 EDN1 18218122 308321 Positive_regulation HES2 FIP1L1 23662039 3188972 Positive_regulation HES2 FIP1L1 25431951 2207376 Positive_regulation HES2 FOXP3 20876311 1560312 Positive_regulation HES2 FOXP3 20876311 1560313 Positive_regulation HES2 FOXP3 22110392 1058595 Positive_regulation HES2 FOXP3 23053394 3158176 Positive_regulation HES2 GATA3 20876311 1560376 Positive_regulation HES2 GPI 18218122 308322 Positive_regulation HES2 NOTCH1 19050759 2401606 Positive_regulation HES2 NOTCH1 19087347 301942 Positive_regulation HES2 NOTCH1 19936191 667333 Positive_regulation HES2 NOTCH1 20628604 2455241 Positive_regulation HES2 NOTCH1 21151987 2485622 Positive_regulation HES2 NOTCH1 21443795 1835817 Positive_regulation HES2 NOTCH1 21586122 305593 Positive_regulation HES2 NOTCH1 21834989 3207343 Positive_regulation HES2 NOTCH1 21915302 2553094 Positive_regulation HES2 NOTCH1 23226563 2725481 Positive_regulation HES2 NOTCH1 24023676 2843254 Positive_regulation HES2 NOTCH1 24563863 187210 Positive_regulation HES2 NOTCH2 19050759 2401607 Positive_regulation HES2 NOTCH2 19087347 301943 Positive_regulation HES2 NOTCH2 19936191 667334 Positive_regulation HES2 NOTCH2 20628604 2455242 Positive_regulation HES2 NOTCH2 21151987 2485623 Positive_regulation HES2 NOTCH2 21443795 1835818 Positive_regulation HES2 NOTCH2 21586122 305594 Positive_regulation HES2 NOTCH2 21834989 3207344 Positive_regulation HES2 NOTCH2 21915302 2553095 Positive_regulation HES2 NOTCH2 24023676 2843255 Positive_regulation HES2 NOTCH2 24563863 187211 Positive_regulation HES2 NOTCH3 19050759 2401608 Positive_regulation HES2 NOTCH3 19087347 301944 Positive_regulation HES2 NOTCH3 19936191 667335 Positive_regulation HES2 NOTCH3 20628604 2455243 Positive_regulation HES2 NOTCH3 21151987 2485624 Positive_regulation HES2 NOTCH3 21443795 1835819 Positive_regulation HES2 NOTCH3 21586122 305595 Positive_regulation HES2 NOTCH3 21834989 3207345 Positive_regulation HES2 NOTCH3 21915302 2553096 Positive_regulation HES2 NOTCH3 24023676 2843256 Positive_regulation HES2 NOTCH3 24563863 187212 Positive_regulation HES2 NOTCH4 19050759 2401609 Positive_regulation HES2 NOTCH4 19087347 301945 Positive_regulation HES2 NOTCH4 19936191 667336 Positive_regulation HES2 NOTCH4 20628604 2455244 Positive_regulation HES2 NOTCH4 21151987 2485625 Positive_regulation HES2 NOTCH4 21443795 1835820 Positive_regulation HES2 NOTCH4 21586122 305596 Positive_regulation HES2 NOTCH4 21834989 3207346 Positive_regulation HES2 NOTCH4 21915302 2553097 Positive_regulation HES2 NOTCH4 24023676 2843257 Positive_regulation HES2 NOTCH4 24563863 187213 Positive_regulation HES2 RBPJ 20628604 2455240 Positive_regulation HES2 RBPJ 22971775 604894 Positive_regulation HES2 RBPJ 24479731 1618652 Positive_regulation HES2 SMAD2 20876311 1560314 Positive_regulation HES2 SMAD3 20876311 1560315 Positive_regulation HES2 VWF 25425769 1160698 Positive_regulation HES5 CCND1 24791612 3203939 Positive_regulation HES5 JAG1 21843347 1229459 Positive_regulation HES5 JAG1 21843347 1229478 Positive_regulation HES5 MAML3 21716644 936389 Positive_regulation HES6 CCND1 24791612 3203938 Positive_regulation HEY1 JAG1 19839776 1236863 Positive_regulation HEY1 JAG1 23158439 358842 Positive_regulation HEY1 PECAM1 18663143 1354146 Positive_regulation HEY2 JAG1 21843347 1229480 Positive_regulation HEY2 PECAM1 18663143 1354149 Positive_regulation HFE TF 22629388 2645435 Positive_regulation HFE TF 23848204 91967 Positive_regulation HGF CCND1 24708550 272615 Positive_regulation HGF CD14 22309608 263413 Positive_regulation HGF EPHB2 18218921 849398 Positive_regulation HGF EPHB2 23028692 2692515 Positive_regulation HGF EPHB2 23341789 496357 Positive_regulation HGF EPHB2 23878598 821643 Positive_regulation HGF EPHB2 24168056 1700798 Positive_regulation HGF EPHB2 24223799 2877071 Positive_regulation HGF EPHB2 24287743 502494 Positive_regulation HGF EPHB2 24655548 245865 Positive_regulation HGF EPHB2 24814316 701141 Positive_regulation HGF F2R 24927773 3102523 Positive_regulation HGF FOXO1 22081023 1961788 Positive_regulation HGF ID1 21068842 1986655 Positive_regulation HGF MAP2K6 25337673 2205702 Positive_regulation HGF MMP28 19375502 1731657 Positive_regulation HGF MMP28 20551596 3078716 Positive_regulation HGF MMP7 20551596 3078731 Positive_regulation HGF PLAU 11953898 421604 Positive_regulation HGF PLAU 16646560 1711381 Positive_regulation HGF PLAU 17134505 312982 Positive_regulation HGF PLAU 17785520 1344452 Positive_regulation HGF PLAU 18691255 806239 Positive_regulation HGF PLAU 20509929 1228452 Positive_regulation HGF PLAU 20551596 3078658 Positive_regulation HGF PLAU 24710554 619640 Positive_regulation HGF PLAU 25268161 505260 Positive_regulation HGF PLAU 8980383 445866 Positive_regulation HGF PLAU 8980383 445868 Positive_regulation HGF TNF 20161853 1043922 Positive_regulation HGF TNF 20200161 1169708 Positive_regulation HGF TNF 20551596 3078647 Positive_regulation HGF TNF 25762184 1623426 Positive_regulation HGF TNF 8980383 445863 Positive_regulation HGF TNFSF10 18992144 251775 Positive_regulation HHIP PDZK1 21653824 1791359 Positive_regulation HIF1A TLR7 25134687 1049892 Positive_regulation HIF1A TNF 12378005 1633006 Positive_regulation HIST1H1C TNF 19696893 3045173 Positive_regulation HIST1H3H CST6 25568937 2367840 Positive_regulation HIST1H3H EPHB2 25254549 2364770 Positive_regulation HIST1H3H UCA1 24876127 758400 Positive_regulation HIST2H2AC CCND1 23637611 2345582 Positive_regulation HIST2H3C ITGAL 17325197 1544509 Positive_regulation HIST3H3 TNF 21857970 2544490 Positive_regulation HIVEP3 HBEGF 24136232 568198 Positive_regulation HIVEP3 HBEGF 24136232 568199 Positive_regulation HIVEP3 TNF 25228904 914150 Positive_regulation HIVEP3 TNF 25228904 914185 Positive_regulation HK1 EPHB2 21085672 2483170 Positive_regulation HK1 EPHB2 21085672 2483204 Positive_regulation HK1 EPHB2 21085672 2483301 Positive_regulation HK2 EPHB2 21085672 2483171 Positive_regulation HK2 EPHB2 21085672 2483205 Positive_regulation HK2 EPHB2 21085672 2483219 Positive_regulation HK2 EPHB2 21085672 2483302 Positive_regulation HK3 EPHB2 21085672 2483172 Positive_regulation HK3 EPHB2 21085672 2483206 Positive_regulation HK3 EPHB2 21085672 2483303 Positive_regulation HLA-A TLR7 20379390 1214487 Positive_regulation HLA-A TNF 1512545 1532294 Positive_regulation HLA-A TNF 18475587 1744465 Positive_regulation HLA-A TNF 18475699 1745443 Positive_regulation HLA-A TNF 1869591 1354843 Positive_regulation HLA-A TNF 1985121 1556571 Positive_regulation HLA-A TNF 2110813 436253 Positive_regulation HLA-A TNF 2170559 1564098 Positive_regulation HLA-A TNF 2258696 1568155 Positive_regulation HLA-A TNF 2258704 1568218 Positive_regulation HLA-A TNF 2258704 1568219 Positive_regulation HLA-A TNF 2450953 1574921 Positive_regulation HLA-A TNF 2450953 1574931 Positive_regulation HLA-A TNF 2504878 1577091 Positive_regulation HLA-A TNF 2921280 1424434 Positive_regulation HLA-A TNF 2921280 1424436 Positive_regulation HLA-A TNF 3049617 1425612 Positive_regulation HLA-A TNF 3138247 1425884 Positive_regulation HLA-A TNF 3309124 1580904 Positive_regulation HLA-A TNF 3491174 1583090 Positive_regulation HLA-A TNF 3655656 1583602 Positive_regulation HLA-A TNF 3772296 1583654 Positive_regulation HLA-A TNF 8478614 1595566 Positive_regulation HLA-A TNF 8691131 1598150 Positive_regulation HLA-B TNF 23698783 1107293 Positive_regulation HLA-DRA JAG1 25317714 1764752 Positive_regulation HLA-DRA TLR7 17918201 807183 Positive_regulation HLA-DRA TLR7 18509450 2389648 Positive_regulation HLA-DRA TLR7 21587207 769684 Positive_regulation HLA-DRA TLR7 23800014 1232213 Positive_regulation HLA-DRA TLR7 25295753 3012746 Positive_regulation HLA-DRA TNF 16368009 412654 Positive_regulation HLA-DRA TNF 7931066 1593222 Positive_regulation HLA-DRA TNF 9236189 1601334 Positive_regulation HLA-DRB1 EPHB2 21738740 2533591 Positive_regulation HLA-DRB1 FAS 22087285 2571276 Positive_regulation HLA-DRB1 FOXO1 21209944 2492510 Positive_regulation HLA-DRB1 JAG1 25317714 1764753 Positive_regulation HLA-DRB1 MAP2K6 21738740 2533597 Positive_regulation HLA-DRB1 MAP2K6 22892844 478756 Positive_regulation HLA-DRB1 NR2F1 22007304 1145374 Positive_regulation HLA-DRB1 OSR1 24931004 1681297 Positive_regulation HLA-DRB1 TLR7 17918201 807193 Positive_regulation HLA-DRB1 TLR7 18509450 2389658 Positive_regulation HLA-DRB1 TLR7 21587207 769694 Positive_regulation HLA-DRB1 TLR7 23800014 1232224 Positive_regulation HLA-DRB1 TLR7 25295753 3012756 Positive_regulation HLA-DRB1 TNF 16368009 412655 Positive_regulation HLA-DRB1 TNF 17592646 250173 Positive_regulation HLA-DRB1 TNF 23191987 357300 Positive_regulation HLA-DRB1 TNF 7931066 1593226 Positive_regulation HLA-DRB1 TNF 9236189 1601336 Positive_regulation HLA-DRB1 TNFSF10 16502485 3230845 Positive_regulation HLA-DRB1 TNFSF10 19352384 432057 Positive_regulation HLA-DRB1 TNFSF10 19352384 432058 Positive_regulation HLA-DRB1 TNFSF10 20113484 1853222 Positive_regulation HLA-DRB1 TNFSF10 20663232 1857146 Positive_regulation HLA-DRB1 TNFSF10 21092294 1860270 Positive_regulation HLA-DRB1 TNFSF10 21209944 2492509 Positive_regulation HLA-DRB1 TNFSF10 21483830 2512305 Positive_regulation HLA-DRB1 TNFSF10 21513580 1861783 Positive_regulation HLA-DRB1 TNFSF10 21513580 1861812 Positive_regulation HLA-DRB1 TNFSF10 21513580 1861887 Positive_regulation HLA-DRB1 TNFSF10 21513580 1861948 Positive_regulation HLA-DRB1 TNFSF10 22087287 2571282 Positive_regulation HLA-DRB1 TNFSF10 22213832 1882542 Positive_regulation HLA-DRB1 TNFSF10 22619505 1136914 Positive_regulation HLA-DRB1 TNFSF10 22666346 2647868 Positive_regulation HLA-DRB1 TNFSF10 22672528 482491 Positive_regulation HLA-DRB1 TNFSF10 22681760 264868 Positive_regulation HLA-DRB1 TNFSF10 22909995 2180674 Positive_regulation HLA-DRB1 TNFSF10 23191987 357301 Positive_regulation HLA-DRB1 TNFSF10 23327610 177629 Positive_regulation HLA-DRB1 TNFSF10 23432760 267892 Positive_regulation HLA-DRB1 TNFSF10 24324958 185710 Positive_regulation HLA-DRB1 TNFSF10 24481457 571858 Positive_regulation HLA-DRB1 TNFSF10 25015549 2195771 Positive_regulation HLA-DRB1 TNFSF10 25015549 2195775 Positive_regulation HLA-DRB1 TNFSF10 25015549 2195790 Positive_regulation HLA-DRB1 TNFSF10 25026275 2195848 Positive_regulation HLA-G TNF 24839609 1621573 Positive_regulation HMG20A PGC 22453831 1933610 Positive_regulation HMG20B PGC 22453831 1933611 Positive_regulation HMGA2 CTGF 23950932 2832796 Positive_regulation HMGA2 MAP2K6 23950932 2832794 Positive_regulation HMGB1 CD14 20706656 1747788 Positive_regulation HMGB1 CD14 24321251 660633 Positive_regulation HMGB1 FAS 20565784 1626066 Positive_regulation HMGB1 FAS 20565784 1626067 Positive_regulation HMGB1 FAS 20565784 1626068 Positive_regulation HMGB1 FAS 20565784 1626069 Positive_regulation HMGB1 FAS 20565784 1626070 Positive_regulation HMGB1 FAS 20565784 1626071 Positive_regulation HMGB1 FAS 20565784 1626072 Positive_regulation HMGB1 FAS 20565784 1626073 Positive_regulation HMGB1 FAS 20565784 1626080 Positive_regulation HMGB1 FAS 20565784 1626081 Positive_regulation HMGB1 FAS 20565784 1626082 Positive_regulation HMGB1 FAS 20565784 1626090 Positive_regulation HMGB1 FAS 20565784 1626091 Positive_regulation HMGB1 FAS 20565784 1626092 Positive_regulation HMGB1 FAS 20565784 1626094 Positive_regulation HMGB1 FAS 20565784 1626095 Positive_regulation HMGB1 FAS 20565784 1626097 Positive_regulation HMGB1 MAP2K6 24058610 2848262 Positive_regulation HMGB1 TLR7 22709825 1663480 Positive_regulation HMGB1 TNF 10952726 1516710 Positive_regulation HMGB1 TNF 16354107 2368633 Positive_regulation HMGB1 TNF 17397533 108192 Positive_regulation HMGB1 TNF 18288272 1741538 Positive_regulation HMGB1 TNF 18346273 110178 Positive_regulation HMGB1 TNF 18346273 110181 Positive_regulation HMGB1 TNF 18346273 110186 Positive_regulation HMGB1 TNF 18582368 110996 Positive_regulation HMGB1 TNF 19064698 1553024 Positive_regulation HMGB1 TNF 21040547 1657244 Positive_regulation HMGB1 TNF 21365018 1912721 Positive_regulation HMGB1 TNF 21406085 313378 Positive_regulation HMGB1 TNF 21406085 313379 Positive_regulation HMGB1 TNF 21406085 313382 Positive_regulation HMGB1 TNF 21406085 313384 Positive_regulation HMGB1 TNF 21507210 3129601 Positive_regulation HMGB1 TNF 21915243 2552646 Positive_regulation HMGB1 TNF 22563397 2626274 Positive_regulation HMGB1 TNF 22778498 1750068 Positive_regulation HMGB1 TNF 23209806 2723128 Positive_regulation HMGB1 TNF 23349558 6674 Positive_regulation HMGB1 TNF 23403473 842968 Positive_regulation HMGB1 TNF 23414442 1666065 Positive_regulation HMGB1 TNF 23414442 1666067 Positive_regulation HMGB1 TNF 23414442 1666068 Positive_regulation HMGB1 TNF 23554654 1225872 Positive_regulation HMGB1 TNF 23626809 2784864 Positive_regulation HMGB1 TNF 23738324 181975 Positive_regulation HMGB1 TNF 23864765 1754267 Positive_regulation HMGB1 TNF 24031744 454292 Positive_regulation HMGB1 TNF 25187820 845004 Positive_regulation HMGB1 TNF 25187820 845005 Positive_regulation HMGB2 TNF 24158500 857059 Positive_regulation HMGCR MAP2K6 19404317 1719350 Positive_regulation HMGCS2 FOXA1 22187655 1638866 Positive_regulation HMGCS2 FOXA1 22238690 2587076 Positive_regulation HMOX1 ANGPT1 18835934 707039 Positive_regulation HMOX1 BPI 19272177 1227021 Positive_regulation HMOX1 EPHB2 23569422 1084493 Positive_regulation HMOX1 EPHB2 23762139 820023 Positive_regulation HMOX1 EPHB2 23762139 820043 Positive_regulation HMOX1 EPHB2 23826208 2811492 Positive_regulation HMOX1 EPHB2 24219867 221088 Positive_regulation HMOX1 EPHB2 24599172 2931857 Positive_regulation HMOX1 EPHB2 24839356 1758773 Positive_regulation HMOX1 EPHB2 24862327 680615 Positive_regulation HMOX1 EPHB2 24999379 2229510 Positive_regulation HMOX1 EPHB2 25133186 196785 Positive_regulation HMOX1 F2R 22541814 125611 Positive_regulation HMOX1 F2R 22541814 125612 Positive_regulation HMOX1 F2R 22541814 125624 Positive_regulation HMOX1 FOXO1 21699736 2112839 Positive_regulation HMOX1 FOXO1 22454632 832702 Positive_regulation HMOX1 FOXO1 22454632 832739 Positive_regulation HMOX1 FOXO1 24115839 742826 Positive_regulation HMOX1 FOXO1 24255720 2882043 Positive_regulation HMOX1 FOXO1 24255720 2882044 Positive_regulation HMOX1 FOXO1 24255720 2882046 Positive_regulation HMOX1 FOXO1 24255720 2882047 Positive_regulation HMOX1 FOXO1 24255720 2882051 Positive_regulation HMOX1 FOXO1 24255720 2882052 Positive_regulation HMOX1 FOXO1 24255720 2882053 Positive_regulation HMOX1 FOXO1 24255720 2882056 Positive_regulation HMOX1 FOXO1 24255720 2882057 Positive_regulation HMOX1 FOXO1 24255720 2882058 Positive_regulation HMOX1 FOXO1 24255720 2882073 Positive_regulation HMOX1 FOXO1 24255720 2882076 Positive_regulation HMOX1 FOXO1 24633152 2934667 Positive_regulation HMOX1 FOXO1 24633152 2934697 Positive_regulation HMOX1 GLP1R 20364157 9811 Positive_regulation HMOX1 GLP1R 20364157 9814 Positive_regulation HMOX1 GLP1R 20364157 9822 Positive_regulation HMOX1 LBP 25045414 2229610 Positive_regulation HMOX1 LBP 25045414 2229618 Positive_regulation HMOX1 PGC 22563483 2626893 Positive_regulation HMOX1 PGC 24350287 185932 Positive_regulation HMOX1 TLR7 21987655 1565626 Positive_regulation HMOX1 TLR7 22586396 951779 Positive_regulation HMOX1 TNF 14657222 1529928 Positive_regulation HMOX1 TNF 18234118 110116 Positive_regulation HMOX1 TNF 18234118 110134 Positive_regulation HMOX1 TNF 21307400 2174860 Positive_regulation HMOX1 TNF 24212776 498329 Positive_regulation HMOX1 TNF 24212776 498367 Positive_regulation HMOX1 TNF 24456852 2233576 Positive_regulation HMOX1 TNF 24755677 2957239 Positive_regulation HMOX1 TNF 25255103 3069563 Positive_regulation HNF1A FOXA1 24963715 2983454 Positive_regulation HNF1A NR2F1 22007304 1145369 Positive_regulation HNF1A OSR1 24931004 1681279 Positive_regulation HNF4A CCND1 22751438 541613 Positive_regulation HNF4A CCND1 22951541 541915 Positive_regulation HNF4A EPHB2 21799848 2538564 Positive_regulation HNF4A FOXA1 24122008 18557 Positive_regulation HNF4A FOXA1 24963715 2983461 Positive_regulation HNF4A NR2F1 22007304 1145376 Positive_regulation HNF4A PGC 24837835 1126957 Positive_regulation HNRNPA1 EPHB2 25324306 2105398 Positive_regulation HNRNPA1 MAP2K6 25324306 2105405 Positive_regulation HNRNPA1 RNASE1 17371836 1338424 Positive_regulation HNRNPA1 RNASE1 19656952 2047027 Positive_regulation HNRNPA1 RNASE7 17371836 1338432 Positive_regulation HNRNPA1 UCA1 24876127 758408 Positive_regulation HNRNPD LAMB3 22160594 1798616 Positive_regulation HNRNPD TNF 23688423 314166 Positive_regulation HNRNPD TNF 9382882 1602112 Positive_regulation HNRNPF CCL17 24701375 2163122 Positive_regulation HNRNPF EDN2 18195069 1548301 Positive_regulation HNRNPF EDN2 18195069 1548302 Positive_regulation HNRNPF EDN2 18195069 1548303 Positive_regulation HNRNPF EDN2 18195069 1548304 Positive_regulation HNRNPF EDN2 18195069 1548383 Positive_regulation HNRNPF EDN2 18195077 1548751 Positive_regulation HNRNPF EPHB2 20967853 135143 Positive_regulation HNRNPF EPHB2 20967853 135144 Positive_regulation HNRNPF EPHB2 20967853 135145 Positive_regulation HNRNPF EPHB2 20967853 135157 Positive_regulation HNRNPF EPHB2 20967853 135166 Positive_regulation HNRNPF EPHB2 20967853 135167 Positive_regulation HNRNPF EPHB2 20967853 135176 Positive_regulation HNRNPF EPHB2 23526794 3149822 Positive_regulation HNRNPF EPHB2 23526794 3149827 Positive_regulation HNRNPF EPHB2 25111504 2996233 Positive_regulation HNRNPF FAS 11104808 1518123 Positive_regulation HNRNPF ITGAL 23221473 3217409 Positive_regulation HNRNPF ITGB2 21980488 2560922 Positive_regulation HNRNPF ITGB2 22238634 2586754 Positive_regulation HNRNPF ITGB2 22238634 2586755 Positive_regulation HNRNPF MAP2K6 21544193 2517139 Positive_regulation HNRNPF MIP 10562317 1513062 Positive_regulation HNRNPF PTGER2 24024207 183893 Positive_regulation HNRNPF TCN1 22750193 1492604 Positive_regulation HNRNPF TLR7 12045249 1523576 Positive_regulation HNRNPF TLR7 15492123 1533698 Positive_regulation HNRNPF TLR7 15795237 1535257 Positive_regulation HNRNPF TLR7 15851485 1535667 Positive_regulation HNRNPF TLR7 17296788 1544348 Positive_regulation HNRNPF TLR7 17296788 1544441 Positive_regulation HNRNPF TLR7 17535975 1546257 Positive_regulation HNRNPF TLR7 17535975 1546262 Positive_regulation HNRNPF TLR7 17535975 1546266 Positive_regulation HNRNPF TLR7 17954572 1547370 Positive_regulation HNRNPF TLR7 17954572 1547377 Positive_regulation HNRNPF TLR7 18086320 109653 Positive_regulation HNRNPF TLR7 18458113 1550652 Positive_regulation HNRNPF TLR7 18458113 1550653 Positive_regulation HNRNPF TLR7 18458113 1550654 Positive_regulation HNRNPF TLR7 18458113 1550758 Positive_regulation HNRNPF TLR7 18533024 352265 Positive_regulation HNRNPF TLR7 19204112 1553901 Positive_regulation HNRNPF TLR7 19204112 1554014 Positive_regulation HNRNPF TLR7 19259329 1146822 Positive_regulation HNRNPF TLR7 19294011 2214899 Positive_regulation HNRNPF TLR7 19476613 113388 Positive_regulation HNRNPF TLR7 19476613 113396 Positive_regulation HNRNPF TLR7 19557165 3044241 Positive_regulation HNRNPF TLR7 19635859 1555470 Positive_regulation HNRNPF TLR7 19667062 1555569 Positive_regulation HNRNPF TLR7 19703986 1555958 Positive_regulation HNRNPF TLR7 19808251 1556436 Positive_regulation HNRNPF TLR7 20021667 1696506 Positive_regulation HNRNPF TLR7 20021667 1696531 Positive_regulation HNRNPF TLR7 20021667 1696537 Positive_regulation HNRNPF TLR7 20308362 1557867 Positive_regulation HNRNPF TLR7 20379390 1214286 Positive_regulation HNRNPF TLR7 20379390 1214326 Positive_regulation HNRNPF TLR7 20379390 1214501 Positive_regulation HNRNPF TLR7 20379390 1214583 Positive_regulation HNRNPF TLR7 20379390 1214636 Positive_regulation HNRNPF TLR7 20533427 774748 Positive_regulation HNRNPF TLR7 20533427 774802 Positive_regulation HNRNPF TLR7 20617179 3047853 Positive_regulation HNRNPF TLR7 20808670 1635242 Positive_regulation HNRNPF TLR7 21059854 1561245 Positive_regulation HNRNPF TLR7 21059854 1561285 Positive_regulation HNRNPF TLR7 21059854 1561325 Positive_regulation HNRNPF TLR7 21059854 1561365 Positive_regulation HNRNPF TLR7 21555485 1563695 Positive_regulation HNRNPF TLR7 21706041 12990 Positive_regulation HNRNPF TLR7 21738472 3052177 Positive_regulation HNRNPF TLR7 21743479 1955598 Positive_regulation HNRNPF TLR7 22019834 1955983 Positive_regulation HNRNPF TLR7 22125457 3152165 Positive_regulation HNRNPF TLR7 22125457 3152264 Positive_regulation HNRNPF TLR7 22190970 633667 Positive_regulation HNRNPF TLR7 22193989 488226 Positive_regulation HNRNPF TLR7 22383883 3055769 Positive_regulation HNRNPF TLR7 22399974 3158732 Positive_regulation HNRNPF TLR7 22566954 900436 Positive_regulation HNRNPF TLR7 22737174 636453 Positive_regulation HNRNPF TLR7 22984435 2688561 Positive_regulation HNRNPF TLR7 23112799 904824 Positive_regulation HNRNPF TLR7 23162764 2161537 Positive_regulation HNRNPF TLR7 23202469 3221629 Positive_regulation HNRNPF TLR7 23202469 3221630 Positive_regulation HNRNPF TLR7 23202493 3221729 Positive_regulation HNRNPF TLR7 23221477 3217462 Positive_regulation HNRNPF TLR7 23223197 3221953 Positive_regulation HNRNPF TLR7 23227255 2725927 Positive_regulation HNRNPF TLR7 23300676 2734632 Positive_regulation HNRNPF TLR7 23484075 179337 Positive_regulation HNRNPF TLR7 23497717 128071 Positive_regulation HNRNPF TLR7 23557436 359135 Positive_regulation HNRNPF TLR7 23593527 2371853 Positive_regulation HNRNPF TLR7 23630623 2785363 Positive_regulation HNRNPF TLR7 23653115 1919878 Positive_regulation HNRNPF TLR7 23690937 2793841 Positive_regulation HNRNPF TLR7 23691339 1151738 Positive_regulation HNRNPF TLR7 23762810 2162438 Positive_regulation HNRNPF TLR7 23781253 637858 Positive_regulation HNRNPF TLR7 24020520 1869602 Positive_regulation HNRNPF TLR7 24204367 909763 Positive_regulation HNRNPF TLR7 24228229 2162695 Positive_regulation HNRNPF TLR7 24335833 1736531 Positive_regulation HNRNPF TLR7 24482744 2162890 Positive_regulation HNRNPF TLR7 24647761 2936336 Positive_regulation HNRNPF TLR7 24705920 2949252 Positive_regulation HNRNPF TLR7 24847328 912700 Positive_regulation HNRNPF TLR7 24847328 912760 Positive_regulation HNRNPF TLR7 25084094 2994072 Positive_regulation HNRNPF TLR7 25084094 2994073 Positive_regulation HNRNPF TLR7 25084094 2994137 Positive_regulation HNRNPF TLR7 25093822 2995298 Positive_regulation HNRNPF TLR7 25111504 2996255 Positive_regulation HNRNPF TLR7 25177709 1623158 Positive_regulation HNRNPF TLR7 25317131 2006746 Positive_regulation HNRNPF TLR7 25317131 2006786 Positive_regulation HNRNPF TLR7 25429207 3216498 Positive_regulation HNRNPF TLR7 25505783 873219 Positive_regulation HNRNPF TLR7 25615690 3070811 Positive_regulation HNRNPF TLR7 PMC2767622 3125133 Positive_regulation HNRNPF TNF 11304549 1519265 Positive_regulation HNRNPF TNF 11686890 3103554 Positive_regulation HNRNPF TNF 11781361 1522109 Positive_regulation HNRNPF TNF 11927638 1523216 Positive_regulation HNRNPF TNF 11927638 1523230 Positive_regulation HNRNPF TNF 12486107 1525643 Positive_regulation HNRNPF TNF 14734523 1530714 Positive_regulation HNRNPF TNF 16847068 1541179 Positive_regulation HNRNPF TNF 16847068 1541187 Positive_regulation HNRNPF TNF 17101734 1543262 Positive_regulation HNRNPF TNF 18039949 1547839 Positive_regulation HNRNPF TNF 18466643 110709 Positive_regulation HNRNPF TNF 19001481 811147 Positive_regulation HNRNPF TNF 19715582 353109 Positive_regulation HNRNPF TNF 20672047 1747579 Positive_regulation HNRNPF TNF 20827419 1216238 Positive_regulation HNRNPF TNF 21527026 649080 Positive_regulation HNRNPF TNF 21658276 508495 Positive_regulation HNRNPF TNF 21980488 2560920 Positive_regulation HNRNPF TNF 22547990 3152595 Positive_regulation HNRNPF TNF 22566829 898644 Positive_regulation HNRNPF TNF 22645622 636181 Positive_regulation HNRNPF TNF 22951718 1631177 Positive_regulation HNRNPF TNF 23627732 1699525 Positive_regulation HNRNPF TNF 23671392 2121274 Positive_regulation HNRNPF TNF 24094416 1041424 Positive_regulation HNRNPF TNF 24453940 2285316 Positive_regulation HNRNPF TNF 24667171 222853 Positive_regulation HNRNPF TNF 25111185 2996191 Positive_regulation HNRNPF TNF 25123797 368547 Positive_regulation HNRNPF TNF 25189159 1142718 Positive_regulation HNRNPF TNF 25435303 3147452 Positive_regulation HNRNPF TNF 25609892 1763563 Positive_regulation HNRNPF TNF 7561684 1590654 Positive_regulation HNRNPF TNF 9529318 1602572 Positive_regulation HNRNPF TNF 9670049 1603242 Positive_regulation HNRNPF TNF 9670049 1603243 Positive_regulation HNRNPF TNF PMC2150969 1605354 Positive_regulation HNRNPF TNFSF10 23170271 2161759 Positive_regulation HNRNPF TP63 16818672 1541009 Positive_regulation HNRNPF TP63 25371910 1623329 Positive_regulation HNRNPF TP63 25552899 743693 Positive_regulation HNRNPH1 CCL17 24701375 2163124 Positive_regulation HNRNPH1 EDN2 18195069 1548313 Positive_regulation HNRNPH1 EDN2 18195069 1548314 Positive_regulation HNRNPH1 EDN2 18195069 1548315 Positive_regulation HNRNPH1 EDN2 18195069 1548316 Positive_regulation HNRNPH1 EDN2 18195069 1548386 Positive_regulation HNRNPH1 EDN2 18195077 1548754 Positive_regulation HNRNPH1 EPHB2 20967853 135146 Positive_regulation HNRNPH1 EPHB2 20967853 135147 Positive_regulation HNRNPH1 EPHB2 20967853 135148 Positive_regulation HNRNPH1 EPHB2 20967853 135158 Positive_regulation HNRNPH1 EPHB2 20967853 135168 Positive_regulation HNRNPH1 EPHB2 20967853 135169 Positive_regulation HNRNPH1 EPHB2 20967853 135177 Positive_regulation HNRNPH1 EPHB2 23526794 3149823 Positive_regulation HNRNPH1 EPHB2 23526794 3149828 Positive_regulation HNRNPH1 EPHB2 25111504 2996234 Positive_regulation HNRNPH1 FAS 11104808 1518124 Positive_regulation HNRNPH1 ITGAL 23221473 3217410 Positive_regulation HNRNPH1 ITGB2 21980488 2560926 Positive_regulation HNRNPH1 ITGB2 22238634 2586756 Positive_regulation HNRNPH1 ITGB2 22238634 2586757 Positive_regulation HNRNPH1 ITGB2 22238634 2586758 Positive_regulation HNRNPH1 MAP2K6 21544193 2517140 Positive_regulation HNRNPH1 MIP 10562317 1513063 Positive_regulation HNRNPH1 PTGER2 24024207 183895 Positive_regulation HNRNPH1 TCN1 22750193 1492605 Positive_regulation HNRNPH1 TLR7 12045249 1523586 Positive_regulation HNRNPH1 TLR7 15492123 1533708 Positive_regulation HNRNPH1 TLR7 15795237 1535267 Positive_regulation HNRNPH1 TLR7 15851485 1535677 Positive_regulation HNRNPH1 TLR7 17296788 1544359 Positive_regulation HNRNPH1 TLR7 17296788 1544451 Positive_regulation HNRNPH1 TLR7 17535975 1546258 Positive_regulation HNRNPH1 TLR7 17535975 1546263 Positive_regulation HNRNPH1 TLR7 17535975 1546267 Positive_regulation HNRNPH1 TLR7 17954572 1547372 Positive_regulation HNRNPH1 TLR7 17954572 1547378 Positive_regulation HNRNPH1 TLR7 18086320 109663 Positive_regulation HNRNPH1 TLR7 18458113 1550683 Positive_regulation HNRNPH1 TLR7 18458113 1550684 Positive_regulation HNRNPH1 TLR7 18458113 1550685 Positive_regulation HNRNPH1 TLR7 18458113 1550768 Positive_regulation HNRNPH1 TLR7 18533024 352275 Positive_regulation HNRNPH1 TLR7 19204112 1553914 Positive_regulation HNRNPH1 TLR7 19204112 1554026 Positive_regulation HNRNPH1 TLR7 19259329 1146832 Positive_regulation HNRNPH1 TLR7 19294011 2214909 Positive_regulation HNRNPH1 TLR7 19476613 113389 Positive_regulation HNRNPH1 TLR7 19476613 113397 Positive_regulation HNRNPH1 TLR7 19557165 3044251 Positive_regulation HNRNPH1 TLR7 19635859 1555480 Positive_regulation HNRNPH1 TLR7 19667062 1555581 Positive_regulation HNRNPH1 TLR7 19703986 1555968 Positive_regulation HNRNPH1 TLR7 19808251 1556446 Positive_regulation HNRNPH1 TLR7 20021667 1696507 Positive_regulation HNRNPH1 TLR7 20021667 1696532 Positive_regulation HNRNPH1 TLR7 20021667 1696538 Positive_regulation HNRNPH1 TLR7 20308362 1557877 Positive_regulation HNRNPH1 TLR7 20379390 1214296 Positive_regulation HNRNPH1 TLR7 20379390 1214336 Positive_regulation HNRNPH1 TLR7 20379390 1214511 Positive_regulation HNRNPH1 TLR7 20379390 1214593 Positive_regulation HNRNPH1 TLR7 20379390 1214646 Positive_regulation HNRNPH1 TLR7 20533427 774758 Positive_regulation HNRNPH1 TLR7 20533427 774812 Positive_regulation HNRNPH1 TLR7 20617179 3047863 Positive_regulation HNRNPH1 TLR7 20808670 1635252 Positive_regulation HNRNPH1 TLR7 21059854 1561255 Positive_regulation HNRNPH1 TLR7 21059854 1561295 Positive_regulation HNRNPH1 TLR7 21059854 1561335 Positive_regulation HNRNPH1 TLR7 21059854 1561375 Positive_regulation HNRNPH1 TLR7 21555485 1563705 Positive_regulation HNRNPH1 TLR7 21706041 13000 Positive_regulation HNRNPH1 TLR7 21738472 3052187 Positive_regulation HNRNPH1 TLR7 21743479 1955599 Positive_regulation HNRNPH1 TLR7 22019834 1955996 Positive_regulation HNRNPH1 TLR7 22125457 3152175 Positive_regulation HNRNPH1 TLR7 22125457 3152274 Positive_regulation HNRNPH1 TLR7 22190970 633677 Positive_regulation HNRNPH1 TLR7 22193989 488236 Positive_regulation HNRNPH1 TLR7 22383883 3055779 Positive_regulation HNRNPH1 TLR7 22399974 3158743 Positive_regulation HNRNPH1 TLR7 22566954 900446 Positive_regulation HNRNPH1 TLR7 22737174 636463 Positive_regulation HNRNPH1 TLR7 22984435 2688571 Positive_regulation HNRNPH1 TLR7 23112799 904825 Positive_regulation HNRNPH1 TLR7 23162764 2161547 Positive_regulation HNRNPH1 TLR7 23202469 3221649 Positive_regulation HNRNPH1 TLR7 23202469 3221650 Positive_regulation HNRNPH1 TLR7 23202493 3221730 Positive_regulation HNRNPH1 TLR7 23221477 3217472 Positive_regulation HNRNPH1 TLR7 23223197 3221955 Positive_regulation HNRNPH1 TLR7 23227255 2725937 Positive_regulation HNRNPH1 TLR7 23300676 2734642 Positive_regulation HNRNPH1 TLR7 23484075 179347 Positive_regulation HNRNPH1 TLR7 23497717 128072 Positive_regulation HNRNPH1 TLR7 23557436 359145 Positive_regulation HNRNPH1 TLR7 23593527 2371854 Positive_regulation HNRNPH1 TLR7 23630623 2785373 Positive_regulation HNRNPH1 TLR7 23653115 1919888 Positive_regulation HNRNPH1 TLR7 23690937 2793851 Positive_regulation HNRNPH1 TLR7 23691339 1151748 Positive_regulation HNRNPH1 TLR7 23762810 2162448 Positive_regulation HNRNPH1 TLR7 23781253 637868 Positive_regulation HNRNPH1 TLR7 24020520 1869612 Positive_regulation HNRNPH1 TLR7 24204367 909773 Positive_regulation HNRNPH1 TLR7 24228229 2162705 Positive_regulation HNRNPH1 TLR7 24335833 1736542 Positive_regulation HNRNPH1 TLR7 24482744 2162900 Positive_regulation HNRNPH1 TLR7 24647761 2936346 Positive_regulation HNRNPH1 TLR7 24705920 2949262 Positive_regulation HNRNPH1 TLR7 24847328 912710 Positive_regulation HNRNPH1 TLR7 24847328 912770 Positive_regulation HNRNPH1 TLR7 25084094 2994092 Positive_regulation HNRNPH1 TLR7 25084094 2994093 Positive_regulation HNRNPH1 TLR7 25084094 2994147 Positive_regulation HNRNPH1 TLR7 25093822 2995300 Positive_regulation HNRNPH1 TLR7 25111504 2996265 Positive_regulation HNRNPH1 TLR7 25177709 1623168 Positive_regulation HNRNPH1 TLR7 25317131 2006756 Positive_regulation HNRNPH1 TLR7 25317131 2006796 Positive_regulation HNRNPH1 TLR7 25429207 3216508 Positive_regulation HNRNPH1 TLR7 25505783 873229 Positive_regulation HNRNPH1 TLR7 25615690 3070821 Positive_regulation HNRNPH1 TLR7 PMC2767622 3125143 Positive_regulation HNRNPH1 TNF 11304549 1519267 Positive_regulation HNRNPH1 TNF 11686890 3103557 Positive_regulation HNRNPH1 TNF 11781361 1522110 Positive_regulation HNRNPH1 TNF 11927638 1523218 Positive_regulation HNRNPH1 TNF 11927638 1523232 Positive_regulation HNRNPH1 TNF 12486107 1525644 Positive_regulation HNRNPH1 TNF 14734523 1530715 Positive_regulation HNRNPH1 TNF 16847068 1541180 Positive_regulation HNRNPH1 TNF 16847068 1541188 Positive_regulation HNRNPH1 TNF 17101734 1543263 Positive_regulation HNRNPH1 TNF 18039949 1547840 Positive_regulation HNRNPH1 TNF 18466643 110715 Positive_regulation HNRNPH1 TNF 19001481 811149 Positive_regulation HNRNPH1 TNF 19715582 353111 Positive_regulation HNRNPH1 TNF 20672047 1747580 Positive_regulation HNRNPH1 TNF 20827419 1216239 Positive_regulation HNRNPH1 TNF 21527026 649082 Positive_regulation HNRNPH1 TNF 21658276 508496 Positive_regulation HNRNPH1 TNF 21980488 2560924 Positive_regulation HNRNPH1 TNF 22547990 3152596 Positive_regulation HNRNPH1 TNF 22566829 898645 Positive_regulation HNRNPH1 TNF 22645622 636182 Positive_regulation HNRNPH1 TNF 22951718 1631179 Positive_regulation HNRNPH1 TNF 23627732 1699526 Positive_regulation HNRNPH1 TNF 23671392 2121279 Positive_regulation HNRNPH1 TNF 24094416 1041428 Positive_regulation HNRNPH1 TNF 24453940 2285317 Positive_regulation HNRNPH1 TNF 24667171 222856 Positive_regulation HNRNPH1 TNF 25111185 2996192 Positive_regulation HNRNPH1 TNF 25123797 368549 Positive_regulation HNRNPH1 TNF 25189159 1142719 Positive_regulation HNRNPH1 TNF 25435303 3147453 Positive_regulation HNRNPH1 TNF 25609892 1763564 Positive_regulation HNRNPH1 TNF 7561684 1590655 Positive_regulation HNRNPH1 TNF 9529318 1602574 Positive_regulation HNRNPH1 TNF 9670049 1603247 Positive_regulation HNRNPH1 TNF 9670049 1603248 Positive_regulation HNRNPH1 TNF PMC2150969 1605355 Positive_regulation HNRNPH1 TNFSF10 23170271 2161760 Positive_regulation HNRNPH1 TP63 16818672 1541014 Positive_regulation HNRNPH1 TP63 25371910 1623332 Positive_regulation HNRNPH1 TP63 25552899 743697 Positive_regulation HNRNPK ANGPT1 24642125 614202 Positive_regulation HNRNPK ANGPT1 24642125 614208 Positive_regulation HNRNPK ANGPT1 24642125 614214 Positive_regulation HNRNPK MMP28 24885469 273253 Positive_regulation HNRNPR SMN2 23383159 2748559 Positive_regulation HNRNPR SMN2 25338097 3018558 Positive_regulation HOMER1 EPHB2 22347189 950740 Positive_regulation HOMER2 EPHB2 22347189 950742 Positive_regulation HOMER3 EPHB2 22347189 950744 Positive_regulation HOXB1 MSX1 21433221 3171294 Positive_regulation HOXB1 MSX1 21433221 3171422 Positive_regulation HOXB1 MSX1 21433221 3171423 Positive_regulation HOXB1 MSX1 25136598 197272 Positive_regulation HOXB13 FOXA1 25206306 2249925 Positive_regulation HOXB2 EGR2 16504111 298670 Positive_regulation HOXB2 EGR2 19208226 1994687 Positive_regulation HOXB2 EGR2 8922394 1457848 Positive_regulation HOXB2 HOXB1 23408898 2342532 Positive_regulation HOXB2 MAFB 16504111 298671 Positive_regulation HOXB2 MAFB 19208226 1994688 Positive_regulation HOXB3 PLAU 10648567 1255407 Positive_regulation HOXB4 CCND1 22915992 1714343 Positive_regulation HOXC4 TLR7 22473011 1933709 Positive_regulation HOXD-AS1 EPHB2 25522241 349976 Positive_regulation HP TNF 9792335 1763820 Positive_regulation HPD PGC 20393151 713802 Positive_regulation HPD TNF 22523581 2620402 Positive_regulation HPD TNF 22523581 2620439 Positive_regulation HPS1 TNF 24852692 3211522 Positive_regulation HPSE EPHB2 23300607 2734075 Positive_regulation HPSE PPBP 20652010 1672287 Positive_regulation HPSE2 AGR2 18616802 1616159 Positive_regulation HRAS CD14 20150966 1213524 Positive_regulation HRAS DGKI 25233099 3008238 Positive_regulation HRAS DGKI 25233099 3008245 Positive_regulation HRAS EFNB1 24868497 3179257 Positive_regulation HRAS EPHB2 17498287 999297 Positive_regulation HRAS EPHB2 18404483 3088056 Positive_regulation HRAS EPHB2 18463697 2289744 Positive_regulation HRAS EPHB2 19015320 1361484 Positive_regulation HRAS EPHB2 19652721 2422715 Positive_regulation HRAS EPHB2 19682393 1646620 Positive_regulation HRAS EPHB2 19826415 2127389 Positive_regulation HRAS EPHB2 21980390 2560146 Positive_regulation HRAS EPHB2 22319531 1067182 Positive_regulation HRAS EPHB2 22384111 2604059 Positive_regulation HRAS EPHB2 22567280 622836 Positive_regulation HRAS EPHB2 22920937 406780 Positive_regulation HRAS EPHB2 23060802 959296 Positive_regulation HRAS EPHB2 23617883 1867939 Positive_regulation HRAS EPHB2 23825558 2809633 Positive_regulation HRAS EPHB2 23908058 3227797 Positive_regulation HRAS EPHB2 23908058 3227798 Positive_regulation HRAS EPHB2 23908058 3227877 Positive_regulation HRAS EPHB2 24141185 1113551 Positive_regulation HRAS EPHB2 24312439 2889382 Positive_regulation HRAS EPHB2 24330074 1482217 Positive_regulation HRAS EPHB2 24684778 1873585 Positive_regulation HRAS EPHB2 24743024 2189214 Positive_regulation HRAS EPHB2 24943349 365048 Positive_regulation HRAS EPHB2 24957684 2232038 Positive_regulation HRAS EPHB2 24994118 2194893 Positive_regulation HRAS EPHB2 25003010 3092917 Positive_regulation HRAS EPHB2 8089186 1444668 Positive_regulation HRAS FOXA1 24073287 2853734 Positive_regulation HRAS FOXA1 24073287 2853740 Positive_regulation HRAS FOXO1 20375467 26941 Positive_regulation HRAS FOXO1 24265619 962911 Positive_regulation HRAS HBEGF 23888518 3185327 Positive_regulation HRAS LBP 20150966 1213525 Positive_regulation HRAS MAP2K6 17498287 999303 Positive_regulation HRAS MAP2K6 17892597 1645758 Positive_regulation HRAS MAP2K6 21072183 2481273 Positive_regulation HRAS MAP2K6 21307646 2223265 Positive_regulation HRAS MAP2K6 21307646 2223586 Positive_regulation HRAS MAP2K6 22384111 2604065 Positive_regulation HRAS MAP2K6 23060802 959302 Positive_regulation HRAS MAP2K6 23825558 2809639 Positive_regulation HRAS MAP2K6 23908058 3227809 Positive_regulation HRAS MAP2K6 23908058 3227810 Positive_regulation HRAS MAP2K6 23908058 3227883 Positive_regulation HRAS MAP2K6 24312439 2889388 Positive_regulation HRAS MAP2K6 24684778 1873591 Positive_regulation HRAS NGFR 25243118 199113 Positive_regulation HRAS PLAU 24971065 965306 Positive_regulation HRAS RASSF10 22500174 1067474 Positive_regulation HRAS TNF 24058780 1705537 Positive_regulation HRES1 CAPN8 19151707 1922144 Positive_regulation HRES1 CAPN8 23759582 543524 Positive_regulation HRG EPHB2 18004277 1902383 Positive_regulation HRG EPHB2 19552798 362294 Positive_regulation HRG MAP2K6 22216327 2585631 Positive_regulation HRH1 ETS1 23209876 3131763 Positive_regulation HRH1 HRH2 20879044 3231901 Positive_regulation HRH1 HRH2 24817841 869319 Positive_regulation HRH1 HRH4 22272324 2589578 Positive_regulation HRH1 IL10 20879044 3231902 Positive_regulation HRH1 IL13 17903241 3108362 Positive_regulation HRH1 IL13 17903241 3108364 Positive_regulation HRH1 JUN 23209876 3131756 Positive_regulation HRH1 PARP1 23209876 3131760 Positive_regulation HRH1 TLR4 25139109 1843250 Positive_regulation HRH1 TNF 24648846 1156521 Positive_regulation HRH1 TRPV1 21655234 2527754 Positive_regulation HRH4 MAP2K6 22569158 1662283 Positive_regulation HRH4 TLR7 23532396 1050490 Positive_regulation HSD11B2 MAPK1 25229504 3008049 Positive_regulation HSD11B2 MAPK10 25229504 3008050 Positive_regulation HSD11B2 MAPK11 25229504 3008051 Positive_regulation HSD11B2 MAPK12 25229504 3008052 Positive_regulation HSD11B2 MAPK13 25229504 3008053 Positive_regulation HSD11B2 MAPK14 25229504 3008054 Positive_regulation HSD11B2 MAPK15 25229504 3008048 Positive_regulation HSD11B2 MAPK3 25229504 3008055 Positive_regulation HSD11B2 MAPK4 25229504 3008056 Positive_regulation HSD11B2 MAPK6 25229504 3008057 Positive_regulation HSD11B2 MAPK7 25229504 3008058 Positive_regulation HSD11B2 MAPK8 25229504 3008059 Positive_regulation HSD11B2 MAPK9 25229504 3008060 Positive_regulation HSD11B2 SP1 25229504 3008045 Positive_regulation HSD17B12 GRIK2 23556457 3187399 Positive_regulation HSD17B12 TNF 22783260 902483 Positive_regulation HSF1 CLU 25138053 2198205 Positive_regulation HSF1 CLU 25138053 2198212 Positive_regulation HSF1 CLU 25503391 1947703 Positive_regulation HSF1 FOXO1 20007934 712141 Positive_regulation HSF1 TNF 24485322 694907 Positive_regulation HSF2 TNF 24485322 694908 Positive_regulation HSF4 DAPK1 24464042 1968772 Positive_regulation HSF4 EPHB2 21208456 1228796 Positive_regulation HSF4 TNF 24485322 694909 Positive_regulation HSF5 TNF 24485322 694906 Positive_regulation HSP90AA1 CAPN8 23425388 275570 Positive_regulation HSP90AA1 CAPN8 23425388 275571 Positive_regulation HSP90AA1 CAPN8 23425388 275842 Positive_regulation HSP90AA1 ETV7 22540023 2107026 Positive_regulation HSP90AA1 JAG1 22351600 778078 Positive_regulation HSP90AA1 JAG1 22351600 778095 Positive_regulation HSP90AA1 JAG1 22351600 778104 Positive_regulation HSP90AA1 JAG1 22351600 778108 Positive_regulation HSP90AA1 MAP2K6 23409030 2753302 Positive_regulation HSP90AA1 NES 15251038 277803 Positive_regulation HSP90AA1 PLAU 19715605 283394 Positive_regulation HSP90AA1 TFPI2 18922470 1876985 Positive_regulation HSP90AA1 TNF 19715605 283392 Positive_regulation HSP90AA1 TNF 22004293 379819 Positive_regulation HSP90AA1 TNF 24580841 3169888 Positive_regulation HSP90AA1 ZFP57 25032857 577421 Positive_regulation HSP90AA1 ZFP57 25032857 577493 Positive_regulation HSP90AB1 PLAT 20553606 256285 Positive_regulation HSP90B1 ETV7 22505622 991913 Positive_regulation HSP90B1 FOXO1 25369332 3022704 Positive_regulation HSPA1A TNF 24213112 499424 Positive_regulation HSPA1B PGC 22453831 1933612 Positive_regulation HSPA5 CAPN8 22069639 3182984 Positive_regulation HSPA5 CLU 23457489 2758641 Positive_regulation HSPA5 CLU 23457489 2758643 Positive_regulation HSPA5 CLU 23457489 2758644 Positive_regulation HSPA5 EPHB2 25403445 3147059 Positive_regulation HSPA5 PGC 22771762 842570 Positive_regulation HSPA5 PGC 22771762 842576 Positive_regulation HSPA5 PGC 24167585 2872231 Positive_regulation HSPA5 TNF 22430489 1567802 Positive_regulation HSPA5 TNF 24387801 1162646 Positive_regulation HSPA5 TNF 25470819 3032057 Positive_regulation HSPA5 TNF 25470819 3032062 Positive_regulation HSPA5 TNF PMC3273066 99511 Positive_regulation HSPA8 TNF 20683885 1237736 Positive_regulation HSPB1 EPHB2 21364669 550155 Positive_regulation HSPB1 TNF 10231001 1049487 Positive_regulation HSPB1 TNF 18472818 1741826 Positive_regulation HSPB1 TNF 23852020 1108382 Positive_regulation HSPB1 TNF 24213112 499425 Positive_regulation HSPB1 TNF 24705157 984838 Positive_regulation HSPB1 TNF 8418204 1595152 Positive_regulation HSPB11 TNF 24213112 499420 Positive_regulation HSPB2 TNF 24213112 499426 Positive_regulation HSPB3 TNF 14624693 658504 Positive_regulation HSPB3 TNF 15588496 1031033 Positive_regulation HSPB3 TNF 16911805 319141 Positive_regulation HSPB3 TNF 16948847 319167 Positive_regulation HSPB3 TNF 17996095 321122 Positive_regulation HSPB3 TNF 19169254 1948686 Positive_regulation HSPB3 TNF 19292917 112973 Positive_regulation HSPB3 TNF 19442267 1696100 Positive_regulation HSPB3 TNF 19794059 711138 Positive_regulation HSPB3 TNF 19794059 711139 Positive_regulation HSPB3 TNF 19835638 117471 Positive_regulation HSPB3 TNF 19835638 117472 Positive_regulation HSPB3 TNF 20585575 2453994 Positive_regulation HSPB3 TNF 20606885 1043928 Positive_regulation HSPB3 TNF 20617138 1215573 Positive_regulation HSPB3 TNF 22220267 1702852 Positive_regulation HSPB3 TNF 22507528 1661588 Positive_regulation HSPB3 TNF 23134590 482614 Positive_regulation HSPB3 TNF 23226040 2249656 Positive_regulation HSPB3 TNF 23251221 637112 Positive_regulation HSPB3 TNF 23576877 1628489 Positive_regulation HSPB3 TNF 23576877 1628496 Positive_regulation HSPB3 TNF 23885264 1226322 Positive_regulation HSPB3 TNF 23889801 344656 Positive_regulation HSPB3 TNF 24023678 2843310 Positive_regulation HSPB3 TNF 24212632 497859 Positive_regulation HSPB3 TNF 24213112 499427 Positive_regulation HSPB3 TNF 24587287 2929227 Positive_regulation HSPB3 TNF 24651473 2936581 Positive_regulation HSPB3 TNF 24688608 2208336 Positive_regulation HSPB3 TNF 24959724 2983186 Positive_regulation HSPB3 TNF 24971370 1621820 Positive_regulation HSPB3 TNF 25050625 2991018 Positive_regulation HSPB3 TNF 25098626 3227952 Positive_regulation HSPB3 TNF 25344771 349444 Positive_regulation HSPB6 TNF 24213112 499421 Positive_regulation HSPB7 TNF 24213112 499428 Positive_regulation HSPB8 TNF 24213112 499422 Positive_regulation HSPB9 TNF 24213112 499423 Positive_regulation HSPD1 MMP28 23956742 1146930 Positive_regulation HSPD1 MMP7 23956742 1146945 Positive_regulation HSPD1 TNF 18021431 3108679 Positive_regulation HSPD1 TNF 20946675 1723324 Positive_regulation HSPD1 TNF 23924945 1109758 Positive_regulation HSPD1 TNF 23956742 1146925 Positive_regulation HSPD1 TNF 25258643 826954 Positive_regulation HSPG2 EPHB2 18404491 3088338 Positive_regulation HSPG2 EPHB2 22904641 490788 Positive_regulation HSPG2 FAS 22942738 1097219 Positive_regulation HSPG2 FZD4 23764852 562603 Positive_regulation HSPG2 GPR115 15928401 1608207 Positive_regulation HSPG2 GPR115 18404494 3088515 Positive_regulation HSPG2 GPR115 18404494 3088516 Positive_regulation HSPG2 GPR115 18404494 3088517 Positive_regulation HSPG2 GPR115 19578389 7821 Positive_regulation HSPG2 GPR132 15928401 1608196 Positive_regulation HSPG2 GPR132 18404494 3088482 Positive_regulation HSPG2 GPR132 18404494 3088483 Positive_regulation HSPG2 GPR132 18404494 3088484 Positive_regulation HSPG2 GPR132 19578389 7810 Positive_regulation HSPG2 GPR87 15928401 1608276 Positive_regulation HSPG2 GPR87 18404494 3088722 Positive_regulation HSPG2 GPR87 18404494 3088723 Positive_regulation HSPG2 GPR87 18404494 3088724 Positive_regulation HSPG2 GPR87 19578389 7890 Positive_regulation HSPG2 OXTR 22190926 1072845 Positive_regulation HSPG2 OXTR 25132821 965782 Positive_regulation HSPG2 TLR7 24498214 2918977 Positive_regulation HSPG2 TNF 1658188 1539809 Positive_regulation HSPG2 TNF 1658188 1539810 Positive_regulation HSPG2 TNF 1658188 1539818 Positive_regulation HSPG2 TNF 8027185 1444187 Positive_regulation HSPG2 TNF 8760826 1598974 Positive_regulation HSPG2 TNF 8760826 1598982 Positive_regulation HSPG2 TNF 8760826 1598991 Positive_regulation HSPG2 TNF 8760826 1598993 Positive_regulation HTN3 SCARA3 24723138 1832360 Positive_regulation HTR1A VSNL1 24465966 2912030 Positive_regulation HTR3A RIC3 20522555 1188040 Positive_regulation HTR3A RIC3 20522555 1188041 Positive_regulation HTR3A RIC3 20522555 1188042 Positive_regulation HTR3A RIC3 20522555 1188051 Positive_regulation HTR3A RIC3 20522555 1188053 Positive_regulation HTR3A RIC3 20522555 1188054 Positive_regulation HTR3A RIC3 20522555 1188059 Positive_regulation HTR3A RIC3 20522555 1188063 Positive_regulation HTR3A RIC3 20522555 1188064 Positive_regulation HTR3B RIC3 20522555 1188043 Positive_regulation HTR3B RIC3 20522555 1188044 Positive_regulation HTRA2 TNS1 25206509 2004912 Positive_regulation HTRA2 TNS1 25206509 2004925 Positive_regulation HYAL2 TNF 11960552 276619 Positive_regulation IAPP EPHB2 25427253 3030508 Positive_regulation IAPP TNF 21935471 2556061 Positive_regulation IARS FOXO1 20028942 712432 Positive_regulation IARS FOXO1 23801714 727560 Positive_regulation IARS FOXO1 23802099 945594 Positive_regulation IARS GLP1R 24843641 1494269 Positive_regulation IARS IFI27 20622167 715504 Positive_regulation IBD2 ARSA 18475455 1743824 Positive_regulation IBD2 CD14 23730203 679426 Positive_regulation IBD2 CHI3L1 19259344 3231599 Positive_regulation IBD2 FAS 25045210 1760158 Positive_regulation IBD2 IL1B 23915129 359253 Positive_regulation IBD2 MUC16 24040367 2847051 Positive_regulation IBD2 TNF 10562322 1513170 Positive_regulation IBD2 TNF 12486099 1525529 Positive_regulation IBD2 TNF 12486099 1525530 Positive_regulation IBD2 TNF 12486099 1525531 Positive_regulation IBD2 TNF 12486099 1525532 Positive_regulation IBD2 TNF 12486099 1525533 Positive_regulation IBD2 TNF 12486099 1525534 Positive_regulation IBD2 TNF 12486099 1525586 Positive_regulation IBD2 TNF 12625840 312767 Positive_regulation IBD2 TNF 15694007 391938 Positive_regulation IBD2 TNF 16259632 1624816 Positive_regulation IBD2 TNF 21853060 2542957 Positive_regulation IBD2 TNF 23414097 1479999 Positive_regulation IBD2 TNF 24339869 2891304 Positive_regulation IBD3 ARSA 18475455 1743816 Positive_regulation IBD3 CD14 23730203 679422 Positive_regulation IBD3 CHI3L1 19259344 3231595 Positive_regulation IBD3 FAS 25045210 1760150 Positive_regulation IBD3 IL1B 23915129 359245 Positive_regulation IBD3 MUC16 24040367 2846991 Positive_regulation IBD3 TNF 10562322 1513166 Positive_regulation IBD3 TNF 12486099 1525497 Positive_regulation IBD3 TNF 12486099 1525498 Positive_regulation IBD3 TNF 12486099 1525499 Positive_regulation IBD3 TNF 12486099 1525500 Positive_regulation IBD3 TNF 12486099 1525501 Positive_regulation IBD3 TNF 12486099 1525502 Positive_regulation IBD3 TNF 12486099 1525582 Positive_regulation IBD3 TNF 12625840 312763 Positive_regulation IBD3 TNF 15694007 391934 Positive_regulation IBD3 TNF 16259632 1624812 Positive_regulation IBD3 TNF 21853060 2542953 Positive_regulation IBD3 TNF 23414097 1479995 Positive_regulation IBD3 TNF 24339869 2891300 Positive_regulation IBD4 ARSA 18475455 1743826 Positive_regulation IBD4 CD14 23730203 679427 Positive_regulation IBD4 CHI3L1 19259344 3231600 Positive_regulation IBD4 FAS 25045210 1760160 Positive_regulation IBD4 IL1B 23915129 359255 Positive_regulation IBD4 MUC16 24040367 2847066 Positive_regulation IBD4 TNF 10562322 1513171 Positive_regulation IBD4 TNF 12486099 1525537 Positive_regulation IBD4 TNF 12486099 1525538 Positive_regulation IBD4 TNF 12486099 1525539 Positive_regulation IBD4 TNF 12486099 1525540 Positive_regulation IBD4 TNF 12486099 1525541 Positive_regulation IBD4 TNF 12486099 1525542 Positive_regulation IBD4 TNF 12486099 1525587 Positive_regulation IBD4 TNF 12625840 312768 Positive_regulation IBD4 TNF 15694007 391939 Positive_regulation IBD4 TNF 16259632 1624817 Positive_regulation IBD4 TNF 21853060 2542958 Positive_regulation IBD4 TNF 23414097 1480000 Positive_regulation IBD4 TNF 24339869 2891305 Positive_regulation IBD5 ARSA 18475455 1743828 Positive_regulation IBD5 CD14 23730203 679428 Positive_regulation IBD5 CHI3L1 19259344 3231601 Positive_regulation IBD5 FAS 25045210 1760162 Positive_regulation IBD5 IL1B 23915129 359257 Positive_regulation IBD5 MUC16 24040367 2847081 Positive_regulation IBD5 TNF 10562322 1513172 Positive_regulation IBD5 TNF 12486099 1525545 Positive_regulation IBD5 TNF 12486099 1525546 Positive_regulation IBD5 TNF 12486099 1525547 Positive_regulation IBD5 TNF 12486099 1525548 Positive_regulation IBD5 TNF 12486099 1525549 Positive_regulation IBD5 TNF 12486099 1525550 Positive_regulation IBD5 TNF 12486099 1525588 Positive_regulation IBD5 TNF 12625840 312769 Positive_regulation IBD5 TNF 15694007 391940 Positive_regulation IBD5 TNF 16259632 1624818 Positive_regulation IBD5 TNF 21853060 2542959 Positive_regulation IBD5 TNF 23414097 1480001 Positive_regulation IBD5 TNF 24339869 2891306 Positive_regulation IBD6 ARSA 18475455 1743830 Positive_regulation IBD6 CD14 23730203 679429 Positive_regulation IBD6 CHI3L1 19259344 3231602 Positive_regulation IBD6 FAS 25045210 1760164 Positive_regulation IBD6 IL1B 23915129 359259 Positive_regulation IBD6 MUC16 24040367 2847096 Positive_regulation IBD6 TNF 10562322 1513173 Positive_regulation IBD6 TNF 12486099 1525553 Positive_regulation IBD6 TNF 12486099 1525554 Positive_regulation IBD6 TNF 12486099 1525555 Positive_regulation IBD6 TNF 12486099 1525556 Positive_regulation IBD6 TNF 12486099 1525557 Positive_regulation IBD6 TNF 12486099 1525558 Positive_regulation IBD6 TNF 12486099 1525589 Positive_regulation IBD6 TNF 12625840 312770 Positive_regulation IBD6 TNF 15694007 391941 Positive_regulation IBD6 TNF 16259632 1624819 Positive_regulation IBD6 TNF 21853060 2542960 Positive_regulation IBD6 TNF 23414097 1480002 Positive_regulation IBD6 TNF 24339869 2891307 Positive_regulation IBD7 ARSA 18475455 1743818 Positive_regulation IBD7 CD14 23730203 679423 Positive_regulation IBD7 CHI3L1 19259344 3231596 Positive_regulation IBD7 FAS 25045210 1760152 Positive_regulation IBD7 IL1B 23915129 359247 Positive_regulation IBD7 MUC16 24040367 2847006 Positive_regulation IBD7 TNF 10562322 1513167 Positive_regulation IBD7 TNF 12486099 1525505 Positive_regulation IBD7 TNF 12486099 1525506 Positive_regulation IBD7 TNF 12486099 1525507 Positive_regulation IBD7 TNF 12486099 1525508 Positive_regulation IBD7 TNF 12486099 1525509 Positive_regulation IBD7 TNF 12486099 1525510 Positive_regulation IBD7 TNF 12486099 1525583 Positive_regulation IBD7 TNF 12625840 312764 Positive_regulation IBD7 TNF 15694007 391935 Positive_regulation IBD7 TNF 16259632 1624813 Positive_regulation IBD7 TNF 21853060 2542954 Positive_regulation IBD7 TNF 23414097 1479996 Positive_regulation IBD7 TNF 24339869 2891301 Positive_regulation IBD8 ARSA 18475455 1743820 Positive_regulation IBD8 CD14 23730203 679424 Positive_regulation IBD8 CHI3L1 19259344 3231597 Positive_regulation IBD8 FAS 25045210 1760154 Positive_regulation IBD8 IL1B 23915129 359249 Positive_regulation IBD8 MUC16 24040367 2847021 Positive_regulation IBD8 TNF 10562322 1513168 Positive_regulation IBD8 TNF 12486099 1525513 Positive_regulation IBD8 TNF 12486099 1525514 Positive_regulation IBD8 TNF 12486099 1525515 Positive_regulation IBD8 TNF 12486099 1525516 Positive_regulation IBD8 TNF 12486099 1525517 Positive_regulation IBD8 TNF 12486099 1525518 Positive_regulation IBD8 TNF 12486099 1525584 Positive_regulation IBD8 TNF 12625840 312765 Positive_regulation IBD8 TNF 15694007 391936 Positive_regulation IBD8 TNF 16259632 1624814 Positive_regulation IBD8 TNF 21853060 2542955 Positive_regulation IBD8 TNF 23414097 1479997 Positive_regulation IBD8 TNF 24339869 2891302 Positive_regulation IBD9 ARSA 18475455 1743822 Positive_regulation IBD9 CD14 23730203 679425 Positive_regulation IBD9 CHI3L1 19259344 3231598 Positive_regulation IBD9 FAS 25045210 1760156 Positive_regulation IBD9 IL1B 23915129 359251 Positive_regulation IBD9 MUC16 24040367 2847036 Positive_regulation IBD9 TNF 10562322 1513169 Positive_regulation IBD9 TNF 12486099 1525521 Positive_regulation IBD9 TNF 12486099 1525522 Positive_regulation IBD9 TNF 12486099 1525523 Positive_regulation IBD9 TNF 12486099 1525524 Positive_regulation IBD9 TNF 12486099 1525525 Positive_regulation IBD9 TNF 12486099 1525526 Positive_regulation IBD9 TNF 12486099 1525585 Positive_regulation IBD9 TNF 12625840 312766 Positive_regulation IBD9 TNF 15694007 391937 Positive_regulation IBD9 TNF 16259632 1624815 Positive_regulation IBD9 TNF 21853060 2542956 Positive_regulation IBD9 TNF 23414097 1479998 Positive_regulation IBD9 TNF 24339869 2891303 Positive_regulation ICAM1 ARSA 20877628 2475397 Positive_regulation ICAM1 CHI3L1 7513010 1589123 Positive_regulation ICAM1 EPHB2 21686182 1091104 Positive_regulation ICAM1 EPHB2 23098564 1231470 Positive_regulation ICAM1 EPHB2 23626475 1715043 Positive_regulation ICAM1 F2R 1385447 1298491 Positive_regulation ICAM1 F2R 24624928 511374 Positive_regulation ICAM1 FAS 16316466 383089 Positive_regulation ICAM1 GLP1R 24428883 510666 Positive_regulation ICAM1 IL1B 10958382 1737143 Positive_regulation ICAM1 IL1B 12537603 3103814 Positive_regulation ICAM1 IL1B 22249085 3129496 Positive_regulation ICAM1 IL1B 23130331 135990 Positive_regulation ICAM1 IL1B 25530684 1763480 Positive_regulation ICAM1 ITGAL 11259095 418401 Positive_regulation ICAM1 ITGAL 1717493 1335615 Positive_regulation ICAM1 ITGAL 22311617 808537 Positive_regulation ICAM1 ITGAL 22952790 2684069 Positive_regulation ICAM1 ITGAL 7518468 1435571 Positive_regulation ICAM1 ITGAL 9298996 1463453 Positive_regulation ICAM1 ITGAL 9314566 1601698 Positive_regulation ICAM1 ITGB2 1346139 1297620 Positive_regulation ICAM1 ITGB2 15566616 658549 Positive_regulation ICAM1 ITGB2 18957484 90860 Positive_regulation ICAM1 ITGB2 21970746 354728 Positive_regulation ICAM1 ITGB2 24945611 2981341 Positive_regulation ICAM1 MAP2K6 16780590 249458 Positive_regulation ICAM1 SELL 8879206 1599146 Positive_regulation ICAM1 TLR7 18509450 2389668 Positive_regulation ICAM1 TNF 10362102 414324 Positive_regulation ICAM1 TNF 10704051 1736816 Positive_regulation ICAM1 TNF 10748240 1515094 Positive_regulation ICAM1 TNF 10958382 1737142 Positive_regulation ICAM1 TNF 11132773 1737247 Positive_regulation ICAM1 TNF 11133391 789756 Positive_regulation ICAM1 TNF 11532196 368606 Positive_regulation ICAM1 TNF 11532196 368607 Positive_regulation ICAM1 TNF 11532196 368608 Positive_regulation ICAM1 TNF 11532196 368609 Positive_regulation ICAM1 TNF 11532196 368610 Positive_regulation ICAM1 TNF 11532196 368612 Positive_regulation ICAM1 TNF 11532196 368613 Positive_regulation ICAM1 TNF 11532196 368614 Positive_regulation ICAM1 TNF 11667965 3102807 Positive_regulation ICAM1 TNF 11667965 3102811 Positive_regulation ICAM1 TNF 11817671 1737998 Positive_regulation ICAM1 TNF 11817671 1738006 Positive_regulation ICAM1 TNF 11817671 1738007 Positive_regulation ICAM1 TNF 12117643 791165 Positive_regulation ICAM1 TNF 12398773 658427 Positive_regulation ICAM1 TNF 12438420 1525222 Positive_regulation ICAM1 TNF 12537603 3103813 Positive_regulation ICAM1 TNF 12581499 1738304 Positive_regulation ICAM1 TNF 12723975 99822 Positive_regulation ICAM1 TNF 12810688 1527676 Positive_regulation ICAM1 TNF 1370496 1297715 Positive_regulation ICAM1 TNF 1383376 1528831 Positive_regulation ICAM1 TNF 1385447 1298493 Positive_regulation ICAM1 TNF 14583784 423746 Positive_regulation ICAM1 TNF 15144561 648844 Positive_regulation ICAM1 TNF 15203563 1739609 Positive_regulation ICAM1 TNF 15642148 102419 Positive_regulation ICAM1 TNF 15694007 391921 Positive_regulation ICAM1 TNF 15809354 1535342 Positive_regulation ICAM1 TNF 15809354 1535344 Positive_regulation ICAM1 TNF 15890069 274367 Positive_regulation ICAM1 TNF 15890069 274368 Positive_regulation ICAM1 TNF 15890069 274369 Positive_regulation ICAM1 TNF 15899029 102745 Positive_regulation ICAM1 TNF 16091140 1624746 Positive_regulation ICAM1 TNF 16091140 1624761 Positive_regulation ICAM1 TNF 16104828 2368415 Positive_regulation ICAM1 TNF 16316466 383088 Positive_regulation ICAM1 TNF 16430772 3106035 Positive_regulation ICAM1 TNF 16445864 3096173 Positive_regulation ICAM1 TNF 16518473 3039120 Positive_regulation ICAM1 TNF 16595000 274394 Positive_regulation ICAM1 TNF 16595000 274396 Positive_regulation ICAM1 TNF 16803639 106172 Positive_regulation ICAM1 TNF 16803639 106173 Positive_regulation ICAM1 TNF 17242961 810073 Positive_regulation ICAM1 TNF 17383656 1143484 Positive_regulation ICAM1 TNF 17383656 1143486 Positive_regulation ICAM1 TNF 1740664 1545116 Positive_regulation ICAM1 TNF 17498286 274423 Positive_regulation ICAM1 TNF 17498286 274424 Positive_regulation ICAM1 TNF 17498286 274432 Positive_regulation ICAM1 TNF 17498286 274435 Positive_regulation ICAM1 TNF 17603905 3091144 Positive_regulation ICAM1 TNF 18096615 2032338 Positive_regulation ICAM1 TNF 18096615 2032339 Positive_regulation ICAM1 TNF 18096615 2032366 Positive_regulation ICAM1 TNF 18096615 2032377 Positive_regulation ICAM1 TNF 18096615 2032381 Positive_regulation ICAM1 TNF 18096615 2032382 Positive_regulation ICAM1 TNF 18289377 2112391 Positive_regulation ICAM1 TNF 18466611 392136 Positive_regulation ICAM1 TNF 18472926 1743195 Positive_regulation ICAM1 TNF 18472928 1743242 Positive_regulation ICAM1 TNF 18472928 1743243 Positive_regulation ICAM1 TNF 18475479 1743981 Positive_regulation ICAM1 TNF 18568424 3090166 Positive_regulation ICAM1 TNF 18931039 707113 Positive_regulation ICAM1 TNF 18931039 707118 Positive_regulation ICAM1 TNF 19228707 513366 Positive_regulation ICAM1 TNF 19351711 708251 Positive_regulation ICAM1 TNF 19570245 3179382 Positive_regulation ICAM1 TNF 19668442 649346 Positive_regulation ICAM1 TNF 19707438 175840 Positive_regulation ICAM1 TNF 19707438 175843 Positive_regulation ICAM1 TNF 19736220 811445 Positive_regulation ICAM1 TNF 19736220 811446 Positive_regulation ICAM1 TNF 19997621 2432996 Positive_regulation ICAM1 TNF 19997623 2311930 Positive_regulation ICAM1 TNF 20181103 1625961 Positive_regulation ICAM1 TNF 20386708 2446394 Positive_regulation ICAM1 TNF 20418897 9879 Positive_regulation ICAM1 TNF 20418897 9880 Positive_regulation ICAM1 TNF 20418897 9881 Positive_regulation ICAM1 TNF 20418897 9882 Positive_regulation ICAM1 TNF 20418897 9896 Positive_regulation ICAM1 TNF 20418897 9897 Positive_regulation ICAM1 TNF 20418897 9903 Positive_regulation ICAM1 TNF 20418897 9904 Positive_regulation ICAM1 TNF 20418897 9906 Positive_regulation ICAM1 TNF 20418897 9907 Positive_regulation ICAM1 TNF 20418897 9922 Positive_regulation ICAM1 TNF 20418897 9923 Positive_regulation ICAM1 TNF 20463823 1078134 Positive_regulation ICAM1 TNF 20565944 626878 Positive_regulation ICAM1 TNF 20604932 119350 Positive_regulation ICAM1 TNF 20652897 774887 Positive_regulation ICAM1 TNF 20661281 2456548 Positive_regulation ICAM1 TNF 20700422 3174628 Positive_regulation ICAM1 TNF 20700422 3174629 Positive_regulation ICAM1 TNF 20700422 3174630 Positive_regulation ICAM1 TNF 20836881 508206 Positive_regulation ICAM1 TNF 20868490 1651266 Positive_regulation ICAM1 TNF 20871618 11891 Positive_regulation ICAM1 TNF 20871620 11959 Positive_regulation ICAM1 TNF 21029292 590584 Positive_regulation ICAM1 TNF 21060724 1084116 Positive_regulation ICAM1 TNF 21152396 1912447 Positive_regulation ICAM1 TNF 21169918 1734804 Positive_regulation ICAM1 TNF 21172007 331849 Positive_regulation ICAM1 TNF 21203448 2490420 Positive_regulation ICAM1 TNF 21261956 3111978 Positive_regulation ICAM1 TNF 21264293 2495222 Positive_regulation ICAM1 TNF 21295490 3157824 Positive_regulation ICAM1 TNF 21436966 629843 Positive_regulation ICAM1 TNF 21436966 629844 Positive_regulation ICAM1 TNF 21436966 629845 Positive_regulation ICAM1 TNF 21436966 629846 Positive_regulation ICAM1 TNF 21468165 1071855 Positive_regulation ICAM1 TNF 21572963 2520267 Positive_regulation ICAM1 TNF 21572963 2520268 Positive_regulation ICAM1 TNF 21572963 2520272 Positive_regulation ICAM1 TNF 21572963 2520273 Positive_regulation ICAM1 TNF 21572963 2520309 Positive_regulation ICAM1 TNF 21572963 2520312 Positive_regulation ICAM1 TNF 21572963 2520315 Positive_regulation ICAM1 TNF 21572963 2520316 Positive_regulation ICAM1 TNF 21698053 1084165 Positive_regulation ICAM1 TNF 21786155 733480 Positive_regulation ICAM1 TNF 21788407 1564371 Positive_regulation ICAM1 TNF 21808585 1682054 Positive_regulation ICAM1 TNF 21843342 411975 Positive_regulation ICAM1 TNF 21843342 411976 Positive_regulation ICAM1 TNF 21863241 809877 Positive_regulation ICAM1 TNF 21904602 2550392 Positive_regulation ICAM1 TNF 21966155 1681778 Positive_regulation ICAM1 TNF 21970746 354737 Positive_regulation ICAM1 TNF 21980488 2560956 Positive_regulation ICAM1 TNF 21995855 627406 Positive_regulation ICAM1 TNF 21995855 627407 Positive_regulation ICAM1 TNF 21995855 627408 Positive_regulation ICAM1 TNF 21995855 627411 Positive_regulation ICAM1 TNF 22013533 1145400 Positive_regulation ICAM1 TNF 22028734 813417 Positive_regulation ICAM1 TNF 22043276 2565966 Positive_regulation ICAM1 TNF 22048166 553354 Positive_regulation ICAM1 TNF 22048166 553355 Positive_regulation ICAM1 TNF 22048166 553421 Positive_regulation ICAM1 TNF 22125674 2115079 Positive_regulation ICAM1 TNF 22128776 1724154 Positive_regulation ICAM1 TNF 22128776 1724157 Positive_regulation ICAM1 TNF 22128776 1724161 Positive_regulation ICAM1 TNF 22128776 1724164 Positive_regulation ICAM1 TNF 22129197 1229978 Positive_regulation ICAM1 TNF 22146102 1733718 Positive_regulation ICAM1 TNF 22195011 2583749 Positive_regulation ICAM1 TNF 22279375 2248278 Positive_regulation ICAM1 TNF 22291719 1156029 Positive_regulation ICAM1 TNF 22474520 814113 Positive_regulation ICAM1 TNF 22536224 980460 Positive_regulation ICAM1 TNF 22536886 291986 Positive_regulation ICAM1 TNF 22536886 291987 Positive_regulation ICAM1 TNF 22536886 291994 Positive_regulation ICAM1 TNF 22536886 291995 Positive_regulation ICAM1 TNF 22536886 291999 Positive_regulation ICAM1 TNF 22536886 292002 Positive_regulation ICAM1 TNF 22536886 292005 Positive_regulation ICAM1 TNF 22547990 3152617 Positive_regulation ICAM1 TNF 22551254 292012 Positive_regulation ICAM1 TNF 22696684 1803881 Positive_regulation ICAM1 TNF 22754320 1095966 Positive_regulation ICAM1 TNF 22822401 952074 Positive_regulation ICAM1 TNF 22837985 940966 Positive_regulation ICAM1 TNF 22941285 15931 Positive_regulation ICAM1 TNF 22966430 3086791 Positive_regulation ICAM1 TNF 23049757 2699415 Positive_regulation ICAM1 TNF 23049757 2699416 Positive_regulation ICAM1 TNF 23049757 2699417 Positive_regulation ICAM1 TNF 23049757 2699418 Positive_regulation ICAM1 TNF 23049757 2699419 Positive_regulation ICAM1 TNF 23049757 2699421 Positive_regulation ICAM1 TNF 23049757 2699422 Positive_regulation ICAM1 TNF 23049757 2699423 Positive_regulation ICAM1 TNF 23049757 2699424 Positive_regulation ICAM1 TNF 23049757 2699425 Positive_regulation ICAM1 TNF 23049757 2699426 Positive_regulation ICAM1 TNF 23049757 2699427 Positive_regulation ICAM1 TNF 23049757 2699428 Positive_regulation ICAM1 TNF 23049757 2699429 Positive_regulation ICAM1 TNF 23049757 2699430 Positive_regulation ICAM1 TNF 23049757 2699431 Positive_regulation ICAM1 TNF 23049757 2699432 Positive_regulation ICAM1 TNF 23049757 2699433 Positive_regulation ICAM1 TNF 23049757 2699434 Positive_regulation ICAM1 TNF 23049757 2699435 Positive_regulation ICAM1 TNF 23049757 2699436 Positive_regulation ICAM1 TNF 23049757 2699437 Positive_regulation ICAM1 TNF 23049757 2699438 Positive_regulation ICAM1 TNF 23071583 2703026 Positive_regulation ICAM1 TNF 23091349 1225111 Positive_regulation ICAM1 TNF 23130241 1043806 Positive_regulation ICAM1 TNF 23130331 135989 Positive_regulation ICAM1 TNF 23130331 135994 Positive_regulation ICAM1 TNF 23136554 1060887 Positive_regulation ICAM1 TNF 23170190 1764594 Positive_regulation ICAM1 TNF 23173923 381202 Positive_regulation ICAM1 TNF 23236421 2726338 Positive_regulation ICAM1 TNF 23243449 816587 Positive_regulation ICAM1 TNF 23243449 816590 Positive_regulation ICAM1 TNF 23264465 1810491 Positive_regulation ICAM1 TNF 23264465 1810503 Positive_regulation ICAM1 TNF 23284977 2731373 Positive_regulation ICAM1 TNF 23285008 2731509 Positive_regulation ICAM1 TNF 23285008 2731512 Positive_regulation ICAM1 TNF 23285008 2731516 Positive_regulation ICAM1 TNF 23285008 2731520 Positive_regulation ICAM1 TNF 23285008 2731524 Positive_regulation ICAM1 TNF 23285008 2731530 Positive_regulation ICAM1 TNF 23285282 2733421 Positive_regulation ICAM1 TNF 23300448 3060287 Positive_regulation ICAM1 TNF 23317476 1155718 Positive_regulation ICAM1 TNF 23317476 1155719 Positive_regulation ICAM1 TNF 23317476 1155720 Positive_regulation ICAM1 TNF 23317476 1155721 Positive_regulation ICAM1 TNF 23317476 1155722 Positive_regulation ICAM1 TNF 23317476 1155729 Positive_regulation ICAM1 TNF 23383064 2747720 Positive_regulation ICAM1 TNF 23505517 2766407 Positive_regulation ICAM1 TNF 23527096 2769360 Positive_regulation ICAM1 TNF 23527096 2769365 Positive_regulation ICAM1 TNF 23533479 817807 Positive_regulation ICAM1 TNF 23592916 1915851 Positive_regulation ICAM1 TNF 23592916 1915852 Positive_regulation ICAM1 TNF 23592916 1915859 Positive_regulation ICAM1 TNF 23592916 1915860 Positive_regulation ICAM1 TNF 23592916 1915861 Positive_regulation ICAM1 TNF 23671702 2792475 Positive_regulation ICAM1 TNF 23671702 2792476 Positive_regulation ICAM1 TNF 23671702 2792477 Positive_regulation ICAM1 TNF 23671702 2792486 Positive_regulation ICAM1 TNF 23671702 2792487 Positive_regulation ICAM1 TNF 23671702 2792488 Positive_regulation ICAM1 TNF 23671702 2792501 Positive_regulation ICAM1 TNF 23671702 2792502 Positive_regulation ICAM1 TNF 23671702 2792503 Positive_regulation ICAM1 TNF 23671702 2792506 Positive_regulation ICAM1 TNF 23671702 2792507 Positive_regulation ICAM1 TNF 23671702 2792511 Positive_regulation ICAM1 TNF 23671702 2792512 Positive_regulation ICAM1 TNF 23671702 2792514 Positive_regulation ICAM1 TNF 23671702 2792515 Positive_regulation ICAM1 TNF 23671702 2792517 Positive_regulation ICAM1 TNF 23671702 2792521 Positive_regulation ICAM1 TNF 23685129 3209466 Positive_regulation ICAM1 TNF 23690670 1752084 Positive_regulation ICAM1 TNF 23718910 536342 Positive_regulation ICAM1 TNF 23728723 17876 Positive_regulation ICAM1 TNF 23728723 17877 Positive_regulation ICAM1 TNF 23728723 17883 Positive_regulation ICAM1 TNF 23728723 17894 Positive_regulation ICAM1 TNF 23728723 17895 Positive_regulation ICAM1 TNF 23728723 17897 Positive_regulation ICAM1 TNF 23770053 1498342 Positive_regulation ICAM1 TNF 23770053 1498345 Positive_regulation ICAM1 TNF 23789107 169893 Positive_regulation ICAM1 TNF 23789107 169894 Positive_regulation ICAM1 TNF 23789107 169941 Positive_regulation ICAM1 TNF 23789107 169942 Positive_regulation ICAM1 TNF 23789107 169950 Positive_regulation ICAM1 TNF 23878502 1916068 Positive_regulation ICAM1 TNF 23878502 1916069 Positive_regulation ICAM1 TNF 23878502 1916070 Positive_regulation ICAM1 TNF 23878502 1916098 Positive_regulation ICAM1 TNF 23884101 220655 Positive_regulation ICAM1 TNF 23884101 220656 Positive_regulation ICAM1 TNF 23895132 1726242 Positive_regulation ICAM1 TNF 23912327 2117650 Positive_regulation ICAM1 TNF 23929007 87355 Positive_regulation ICAM1 TNF 23929007 87359 Positive_regulation ICAM1 TNF 23929007 87361 Positive_regulation ICAM1 TNF 23972823 1666977 Positive_regulation ICAM1 TNF 23972823 1666978 Positive_regulation ICAM1 TNF 23972823 1666979 Positive_regulation ICAM1 TNF 23977989 220702 Positive_regulation ICAM1 TNF 23977989 220703 Positive_regulation ICAM1 TNF 23977989 220704 Positive_regulation ICAM1 TNF 23977989 220705 Positive_regulation ICAM1 TNF 23977989 220706 Positive_regulation ICAM1 TNF 23977989 220714 Positive_regulation ICAM1 TNF 23977989 220715 Positive_regulation ICAM1 TNF 23977989 220716 Positive_regulation ICAM1 TNF 23977989 220717 Positive_regulation ICAM1 TNF 23977989 220718 Positive_regulation ICAM1 TNF 23977989 220719 Positive_regulation ICAM1 TNF 23977989 220720 Positive_regulation ICAM1 TNF 23977989 220721 Positive_regulation ICAM1 TNF 23977989 220722 Positive_regulation ICAM1 TNF 23977989 220725 Positive_regulation ICAM1 TNF 23977989 220726 Positive_regulation ICAM1 TNF 23977989 220727 Positive_regulation ICAM1 TNF 23977989 220728 Positive_regulation ICAM1 TNF 23987139 412464 Positive_regulation ICAM1 TNF 23987139 412465 Positive_regulation ICAM1 TNF 23988189 732584 Positive_regulation ICAM1 TNF 23991146 2841167 Positive_regulation ICAM1 TNF 24069252 2852295 Positive_regulation ICAM1 TNF 24069252 2852328 Positive_regulation ICAM1 TNF 24080027 1728353 Positive_regulation ICAM1 TNF 24080027 1728354 Positive_regulation ICAM1 TNF 24098382 2856013 Positive_regulation ICAM1 TNF 24106604 1764612 Positive_regulation ICAM1 TNF 24116032 2864991 Positive_regulation ICAM1 TNF 24228622 359341 Positive_regulation ICAM1 TNF 24228622 359349 Positive_regulation ICAM1 TNF 24237643 1728467 Positive_regulation ICAM1 TNF 24237643 1728469 Positive_regulation ICAM1 TNF 24286322 222131 Positive_regulation ICAM1 TNF 24311895 1755540 Positive_regulation ICAM1 TNF 24312346 2888814 Positive_regulation ICAM1 TNF 24312346 2888817 Positive_regulation ICAM1 TNF 24312436 2889326 Positive_regulation ICAM1 TNF 24327798 1755588 Positive_regulation ICAM1 TNF 24371374 1755979 Positive_regulation ICAM1 TNF 24371453 824993 Positive_regulation ICAM1 TNF 24428883 510665 Positive_regulation ICAM1 TNF 24479486 1667591 Positive_regulation ICAM1 TNF 24479486 1667599 Positive_regulation ICAM1 TNF 24482647 95964 Positive_regulation ICAM1 TNF 24490631 131692 Positive_regulation ICAM1 TNF 24502696 1233151 Positive_regulation ICAM1 TNF 24502696 1233152 Positive_regulation ICAM1 TNF 24502696 1233254 Positive_regulation ICAM1 TNF 24551209 2923349 Positive_regulation ICAM1 TNF 24563688 2924006 Positive_regulation ICAM1 TNF 24603712 2931978 Positive_regulation ICAM1 TNF 24612782 295941 Positive_regulation ICAM1 TNF 24649404 853723 Positive_regulation ICAM1 TNF 24649404 853726 Positive_regulation ICAM1 TNF 24649404 853727 Positive_regulation ICAM1 TNF 24649404 853732 Positive_regulation ICAM1 TNF 24649404 853737 Positive_regulation ICAM1 TNF 24651155 3066387 Positive_regulation ICAM1 TNF 24707183 3177141 Positive_regulation ICAM1 TNF 24752205 2956458 Positive_regulation ICAM1 TNF 24752205 2956459 Positive_regulation ICAM1 TNF 24752205 2956461 Positive_regulation ICAM1 TNF 24864133 1758812 Positive_regulation ICAM1 TNF 24882978 88406 Positive_regulation ICAM1 TNF 24887557 2975925 Positive_regulation ICAM1 TNF 24887557 2975926 Positive_regulation ICAM1 TNF 24887557 2975927 Positive_regulation ICAM1 TNF 24887557 2975929 Positive_regulation ICAM1 TNF 24887557 2975930 Positive_regulation ICAM1 TNF 24887557 2975931 Positive_regulation ICAM1 TNF 24887557 2975932 Positive_regulation ICAM1 TNF 24891765 1759472 Positive_regulation ICAM1 TNF 24940033 1917051 Positive_regulation ICAM1 TNF 24940033 1917052 Positive_regulation ICAM1 TNF 24940033 1917053 Positive_regulation ICAM1 TNF 24940033 1917054 Positive_regulation ICAM1 TNF 24940033 1917055 Positive_regulation ICAM1 TNF 24940033 1917056 Positive_regulation ICAM1 TNF 24940033 1917057 Positive_regulation ICAM1 TNF 24940033 1917077 Positive_regulation ICAM1 TNF 24940033 1917079 Positive_regulation ICAM1 TNF 24940033 1917080 Positive_regulation ICAM1 TNF 24940033 1917084 Positive_regulation ICAM1 TNF 24967146 3151702 Positive_regulation ICAM1 TNF 24970122 207224 Positive_regulation ICAM1 TNF 24970122 207225 Positive_regulation ICAM1 TNF 24970122 207226 Positive_regulation ICAM1 TNF 24970122 207227 Positive_regulation ICAM1 TNF 24979620 2985652 Positive_regulation ICAM1 TNF 24979620 2985654 Positive_regulation ICAM1 TNF 24980747 1576950 Positive_regulation ICAM1 TNF 24987732 3156723 Positive_regulation ICAM1 TNF 24991819 2986317 Positive_regulation ICAM1 TNF 25003339 2986962 Positive_regulation ICAM1 TNF 25003339 2986964 Positive_regulation ICAM1 TNF 25025040 194664 Positive_regulation ICAM1 TNF 25032222 194858 Positive_regulation ICAM1 TNF 25032222 194859 Positive_regulation ICAM1 TNF 25032222 194860 Positive_regulation ICAM1 TNF 25032222 194861 Positive_regulation ICAM1 TNF 25032222 194862 Positive_regulation ICAM1 TNF 25032222 194869 Positive_regulation ICAM1 TNF 25032222 194872 Positive_regulation ICAM1 TNF 25032222 194873 Positive_regulation ICAM1 TNF 25032222 194874 Positive_regulation ICAM1 TNF 25032222 194876 Positive_regulation ICAM1 TNF 25032222 194881 Positive_regulation ICAM1 TNF 25032222 194883 Positive_regulation ICAM1 TNF 25032222 194884 Positive_regulation ICAM1 TNF 25152696 1628024 Positive_regulation ICAM1 TNF 25177551 865272 Positive_regulation ICAM1 TNF 25239871 32262 Positive_regulation ICAM1 TNF 25258680 1675225 Positive_regulation ICAM1 TNF 25258680 1675235 Positive_regulation ICAM1 TNF 25265022 3011105 Positive_regulation ICAM1 TNF 25328285 1763077 Positive_regulation ICAM1 TNF 25329155 3015904 Positive_regulation ICAM1 TNF 25352747 1917425 Positive_regulation ICAM1 TNF 25379003 1615508 Positive_regulation ICAM1 TNF 25379003 1615510 Positive_regulation ICAM1 TNF 25379003 1615511 Positive_regulation ICAM1 TNF 25379003 1615514 Positive_regulation ICAM1 TNF 25379003 1615528 Positive_regulation ICAM1 TNF 25470819 3032059 Positive_regulation ICAM1 TNF 25470819 3032064 Positive_regulation ICAM1 TNF 25470819 3032066 Positive_regulation ICAM1 TNF 25525444 827361 Positive_regulation ICAM1 TNF 25530974 1496795 Positive_regulation ICAM1 TNF 3128630 1580271 Positive_regulation ICAM1 TNF 3134364 1425871 Positive_regulation ICAM1 TNF 7520473 1589464 Positive_regulation ICAM1 TNF 7520473 1589465 Positive_regulation ICAM1 TNF 7520473 1589466 Positive_regulation ICAM1 TNF 7520473 1589467 Positive_regulation ICAM1 TNF 7520473 1589472 Positive_regulation ICAM1 TNF 7536156 796068 Positive_regulation ICAM1 TNF 7540655 1590372 Positive_regulation ICAM1 TNF 7593174 1437469 Positive_regulation ICAM1 TNF 7705312 796399 Positive_regulation ICAM1 TNF 7716973 3230164 Positive_regulation ICAM1 TNF 7908214 444476 Positive_regulation ICAM1 TNF 8315391 1594877 Positive_regulation ICAM1 TNF 8386742 1595092 Positive_regulation ICAM1 TNF 8386742 1595095 Positive_regulation ICAM1 TNF 8666939 1597346 Positive_regulation ICAM1 TNF 9400717 797371 Positive_regulation ICAM1 TNF 9400721 797400 Positive_regulation ICAM1 TNF 9400742 797437 Positive_regulation ICAM1 TNF 9400742 797438 Positive_regulation ICAM1 TNF 9788898 798139 Positive_regulation ICAM1 TNF 9788898 798140 Positive_regulation ICAM1 TNF 9788898 798141 Positive_regulation ICAM1 TNF 9832561 1472138 Positive_regulation ICAM1 TNF PMC2669563 3179423 Positive_regulation ICAM1 TNFSF10 21562052 1637159 Positive_regulation ICAM1 TNFSF10 22048166 553295 Positive_regulation ICAM1 TNFSF10 22048166 553296 Positive_regulation ICAM1 TNFSF10 22048166 553297 Positive_regulation ICAM1 TNFSF10 22048166 553298 Positive_regulation ICAM1 TNFSF10 22048166 553422 Positive_regulation ICAM2 ITGB2 24317296 1487271 Positive_regulation ICAM2 ITGB2 7744962 1440108 Positive_regulation ICAM2 TNF 18096615 2032368 Positive_regulation ICAM2 TNF 19351711 708252 Positive_regulation ICAM2 TNF 20463823 1078135 Positive_regulation ICAM2 TNF 21172007 331850 Positive_regulation ICAM2 TNF 21904602 2550393 Positive_regulation ICAM2 TNF 23091349 1225112 Positive_regulation ICAM2 TNF 24371374 1755980 Positive_regulation ICAM2 TNF 24940033 1917062 Positive_regulation ICAM2 TNF 25265022 3011106 Positive_regulation ICAM2 TNF 8315391 1594878 Positive_regulation ICAM2 TNF 9400717 797372 Positive_regulation ICAM3 ITGAL 7518468 1435572 Positive_regulation ICAM3 ITGAL 7901223 1443336 Positive_regulation ICAM3 ITGB2 7905020 1592895 Positive_regulation ICAM3 TNF 18096615 2032370 Positive_regulation ICAM3 TNF 19351711 708253 Positive_regulation ICAM3 TNF 20463823 1078136 Positive_regulation ICAM3 TNF 21172007 331851 Positive_regulation ICAM3 TNF 21904602 2550394 Positive_regulation ICAM3 TNF 23091349 1225113 Positive_regulation ICAM3 TNF 24371374 1755981 Positive_regulation ICAM3 TNF 24940033 1917065 Positive_regulation ICAM3 TNF 25265022 3011107 Positive_regulation ICAM3 TNF 8315391 1594879 Positive_regulation ICAM3 TNF 9400717 797373 Positive_regulation ICAM4 TNF 18096615 2032372 Positive_regulation ICAM4 TNF 19351711 708254 Positive_regulation ICAM4 TNF 20463823 1078137 Positive_regulation ICAM4 TNF 21172007 331852 Positive_regulation ICAM4 TNF 21904602 2550395 Positive_regulation ICAM4 TNF 23091349 1225114 Positive_regulation ICAM4 TNF 24371374 1755982 Positive_regulation ICAM4 TNF 24940033 1917068 Positive_regulation ICAM4 TNF 25265022 3011108 Positive_regulation ICAM4 TNF 8315391 1594880 Positive_regulation ICAM4 TNF 9400717 797374 Positive_regulation ICAM5 MMP28 17682049 1343003 Positive_regulation ICAM5 MMP28 23844251 2819630 Positive_regulation ICAM5 MMP28 24853857 2973079 Positive_regulation ICAM5 MMP7 17682049 1343019 Positive_regulation ICAM5 MMP7 23844251 2819645 Positive_regulation ICAM5 MMP7 24853857 2973094 Positive_regulation ICAM5 TNF 18096615 2032374 Positive_regulation ICAM5 TNF 19351711 708255 Positive_regulation ICAM5 TNF 20463823 1078138 Positive_regulation ICAM5 TNF 21172007 331853 Positive_regulation ICAM5 TNF 21904602 2550396 Positive_regulation ICAM5 TNF 23091349 1225115 Positive_regulation ICAM5 TNF 24371374 1755983 Positive_regulation ICAM5 TNF 24940033 1917071 Positive_regulation ICAM5 TNF 25265022 3011109 Positive_regulation ICAM5 TNF 8315391 1594881 Positive_regulation ICAM5 TNF 9400717 797375 Positive_regulation ICK FOXA1 20459822 1855046 Positive_regulation ICK FOXA1 20459822 1855047 Positive_regulation ICOS EPHB2 24378539 1574357 Positive_regulation ICOS EPHB2 24378539 1574358 Positive_regulation ICOSLG TNF 11094427 98123 Positive_regulation ICOSLG TNF 22567028 634387 Positive_regulation ID1 ABL1 22204395 262996 Positive_regulation ID1 ACKR3 24256728 1991174 Positive_regulation ID1 ACVR1 23593444 2781404 Positive_regulation ID1 ACVR1 23593444 2781406 Positive_regulation ID1 ACVRL1 16594992 274382 Positive_regulation ID1 ACVRL1 25393508 1134143 Positive_regulation ID1 AKT1 22139302 1879362 Positive_regulation ID1 AKT1 22139302 1879402 Positive_regulation ID1 AKT1 22139302 1879415 Positive_regulation ID1 AKT1 22139302 1879450 Positive_regulation ID1 AKT2 22139302 1879363 Positive_regulation ID1 AKT2 22139302 1879403 Positive_regulation ID1 AKT2 22139302 1879416 Positive_regulation ID1 AKT2 22139302 1879451 Positive_regulation ID1 AKT3 22139302 1879364 Positive_regulation ID1 AKT3 22139302 1879404 Positive_regulation ID1 AKT3 22139302 1879417 Positive_regulation ID1 AKT3 22139302 1879452 Positive_regulation ID1 BCR 22204395 262993 Positive_regulation ID1 BMI1 24572994 1142512 Positive_regulation ID1 BMP1 17509151 1999731 Positive_regulation ID1 BMP1 22540193 244960 Positive_regulation ID1 BMP1 22540193 245009 Positive_regulation ID1 BMP1 22540193 245018 Positive_regulation ID1 BMP1 22573038 555536 Positive_regulation ID1 BMP1 23675417 2792553 Positive_regulation ID1 BMP1 23675417 2792819 Positive_regulation ID1 BMP1 24160469 1870154 Positive_regulation ID1 BMP1 24224048 2877997 Positive_regulation ID1 BMP1 24227947 1716241 Positive_regulation ID1 BMP1 24347544 752247 Positive_regulation ID1 BMP1 24508480 699131 Positive_regulation ID1 BMP1 24554596 2212951 Positive_regulation ID1 BMP1 24554596 2212952 Positive_regulation ID1 BMP1 24554596 2213099 Positive_regulation ID1 BMP1 24850914 2213439 Positive_regulation ID1 BMP1 25010525 3068578 Positive_regulation ID1 BMP1 25010525 3068626 Positive_regulation ID1 BMP1 PMC3332507 134881 Positive_regulation ID1 BMP10 17509151 1999739 Positive_regulation ID1 BMP10 22540193 244968 Positive_regulation ID1 BMP10 22540193 245017 Positive_regulation ID1 BMP10 22540193 245026 Positive_regulation ID1 BMP10 22573038 555544 Positive_regulation ID1 BMP10 23675417 2792561 Positive_regulation ID1 BMP10 23675417 2792827 Positive_regulation ID1 BMP10 24160469 1870162 Positive_regulation ID1 BMP10 24224048 2878005 Positive_regulation ID1 BMP10 24227947 1716249 Positive_regulation ID1 BMP10 24347544 752255 Positive_regulation ID1 BMP10 24508480 699139 Positive_regulation ID1 BMP10 24554596 2212967 Positive_regulation ID1 BMP10 24554596 2212968 Positive_regulation ID1 BMP10 24554596 2213107 Positive_regulation ID1 BMP10 24850914 2213447 Positive_regulation ID1 BMP10 25010525 3068586 Positive_regulation ID1 BMP10 25010525 3068634 Positive_regulation ID1 BMP10 PMC3332507 134889 Positive_regulation ID1 BMP15 17509151 1999732 Positive_regulation ID1 BMP15 22540193 244961 Positive_regulation ID1 BMP15 22540193 245010 Positive_regulation ID1 BMP15 22540193 245019 Positive_regulation ID1 BMP15 22573038 555537 Positive_regulation ID1 BMP15 23675417 2792554 Positive_regulation ID1 BMP15 23675417 2792820 Positive_regulation ID1 BMP15 24160469 1870155 Positive_regulation ID1 BMP15 24224048 2877998 Positive_regulation ID1 BMP15 24227947 1716242 Positive_regulation ID1 BMP15 24347544 752248 Positive_regulation ID1 BMP15 24508480 699132 Positive_regulation ID1 BMP15 24554596 2212953 Positive_regulation ID1 BMP15 24554596 2212954 Positive_regulation ID1 BMP15 24554596 2213100 Positive_regulation ID1 BMP15 24850914 2213440 Positive_regulation ID1 BMP15 25010525 3068579 Positive_regulation ID1 BMP15 25010525 3068627 Positive_regulation ID1 BMP15 PMC3332507 134882 Positive_regulation ID1 BMP2 17509151 1999733 Positive_regulation ID1 BMP2 21998639 2561814 Positive_regulation ID1 BMP2 22410100 124979 Positive_regulation ID1 BMP2 22540193 244962 Positive_regulation ID1 BMP2 22540193 244981 Positive_regulation ID1 BMP2 22540193 245004 Positive_regulation ID1 BMP2 22540193 245011 Positive_regulation ID1 BMP2 22540193 245020 Positive_regulation ID1 BMP2 22573038 555538 Positive_regulation ID1 BMP2 22815831 2666285 Positive_regulation ID1 BMP2 23675417 2792555 Positive_regulation ID1 BMP2 23675417 2792821 Positive_regulation ID1 BMP2 23864860 1069735 Positive_regulation ID1 BMP2 24160469 1870156 Positive_regulation ID1 BMP2 24205156 2875524 Positive_regulation ID1 BMP2 24224048 2877999 Positive_regulation ID1 BMP2 24227947 1716243 Positive_regulation ID1 BMP2 24312319 2888502 Positive_regulation ID1 BMP2 24347544 752249 Positive_regulation ID1 BMP2 24459666 186645 Positive_regulation ID1 BMP2 24508480 699133 Positive_regulation ID1 BMP2 24554596 2212955 Positive_regulation ID1 BMP2 24554596 2212956 Positive_regulation ID1 BMP2 24554596 2213101 Positive_regulation ID1 BMP2 24850914 2213441 Positive_regulation ID1 BMP2 24914764 1127408 Positive_regulation ID1 BMP2 24970809 2193996 Positive_regulation ID1 BMP2 25010525 3068580 Positive_regulation ID1 BMP2 25010525 3068628 Positive_regulation ID1 BMP2 25010525 3068644 Positive_regulation ID1 BMP2 7798324 1441801 Positive_regulation ID1 BMP2 PMC3332507 134883 Positive_regulation ID1 BMP3 17509151 1999734 Positive_regulation ID1 BMP3 22540193 244963 Positive_regulation ID1 BMP3 22540193 245012 Positive_regulation ID1 BMP3 22540193 245021 Positive_regulation ID1 BMP3 22573038 555539 Positive_regulation ID1 BMP3 23675417 2792556 Positive_regulation ID1 BMP3 23675417 2792822 Positive_regulation ID1 BMP3 24160469 1870157 Positive_regulation ID1 BMP3 24224048 2878000 Positive_regulation ID1 BMP3 24227947 1716244 Positive_regulation ID1 BMP3 24347544 752250 Positive_regulation ID1 BMP3 24508480 699134 Positive_regulation ID1 BMP3 24554596 2212957 Positive_regulation ID1 BMP3 24554596 2212958 Positive_regulation ID1 BMP3 24554596 2213102 Positive_regulation ID1 BMP3 24850914 2213442 Positive_regulation ID1 BMP3 25010525 3068581 Positive_regulation ID1 BMP3 25010525 3068629 Positive_regulation ID1 BMP3 PMC3332507 134884 Positive_regulation ID1 BMP4 17509151 1999735 Positive_regulation ID1 BMP4 19290061 2408095 Positive_regulation ID1 BMP4 20187934 1676849 Positive_regulation ID1 BMP4 20187934 1676850 Positive_regulation ID1 BMP4 21949000 720829 Positive_regulation ID1 BMP4 21996749 2143791 Positive_regulation ID1 BMP4 21996749 2143945 Positive_regulation ID1 BMP4 21996749 2144036 Positive_regulation ID1 BMP4 22540193 244964 Positive_regulation ID1 BMP4 22540193 245013 Positive_regulation ID1 BMP4 22540193 245022 Positive_regulation ID1 BMP4 22573038 555540 Positive_regulation ID1 BMP4 22821565 2079794 Positive_regulation ID1 BMP4 23675417 2792557 Positive_regulation ID1 BMP4 23675417 2792823 Positive_regulation ID1 BMP4 23840733 2816252 Positive_regulation ID1 BMP4 24116187 2865767 Positive_regulation ID1 BMP4 24116187 2865771 Positive_regulation ID1 BMP4 24160469 1870158 Positive_regulation ID1 BMP4 24224048 2878001 Positive_regulation ID1 BMP4 24227947 1716245 Positive_regulation ID1 BMP4 24347544 752251 Positive_regulation ID1 BMP4 24508480 699135 Positive_regulation ID1 BMP4 24554596 2212959 Positive_regulation ID1 BMP4 24554596 2212960 Positive_regulation ID1 BMP4 24554596 2213103 Positive_regulation ID1 BMP4 24850914 2213443 Positive_regulation ID1 BMP4 25010525 3068582 Positive_regulation ID1 BMP4 25010525 3068630 Positive_regulation ID1 BMP4 PMC3332507 134885 Positive_regulation ID1 BMP5 17509151 1999736 Positive_regulation ID1 BMP5 22540193 244965 Positive_regulation ID1 BMP5 22540193 245014 Positive_regulation ID1 BMP5 22540193 245023 Positive_regulation ID1 BMP5 22573038 555541 Positive_regulation ID1 BMP5 23675417 2792558 Positive_regulation ID1 BMP5 23675417 2792824 Positive_regulation ID1 BMP5 24160469 1870159 Positive_regulation ID1 BMP5 24224048 2878002 Positive_regulation ID1 BMP5 24227947 1716246 Positive_regulation ID1 BMP5 24347544 752252 Positive_regulation ID1 BMP5 24508480 699136 Positive_regulation ID1 BMP5 24554596 2212961 Positive_regulation ID1 BMP5 24554596 2212962 Positive_regulation ID1 BMP5 24554596 2213104 Positive_regulation ID1 BMP5 24850914 2213444 Positive_regulation ID1 BMP5 25010525 3068583 Positive_regulation ID1 BMP5 25010525 3068631 Positive_regulation ID1 BMP5 PMC3332507 134886 Positive_regulation ID1 BMP6 15877825 350603 Positive_regulation ID1 BMP6 15877825 350604 Positive_regulation ID1 BMP6 17509151 1999737 Positive_regulation ID1 BMP6 22540193 244966 Positive_regulation ID1 BMP6 22540193 245015 Positive_regulation ID1 BMP6 22540193 245024 Positive_regulation ID1 BMP6 22573038 555542 Positive_regulation ID1 BMP6 23675417 2792559 Positive_regulation ID1 BMP6 23675417 2792825 Positive_regulation ID1 BMP6 24160469 1870160 Positive_regulation ID1 BMP6 24224048 2878003 Positive_regulation ID1 BMP6 24227947 1716247 Positive_regulation ID1 BMP6 24347544 752253 Positive_regulation ID1 BMP6 24508480 699137 Positive_regulation ID1 BMP6 24554596 2212963 Positive_regulation ID1 BMP6 24554596 2212964 Positive_regulation ID1 BMP6 24554596 2213105 Positive_regulation ID1 BMP6 24850914 2213445 Positive_regulation ID1 BMP6 25010525 3068584 Positive_regulation ID1 BMP6 25010525 3068632 Positive_regulation ID1 BMP6 PMC3332507 134887 Positive_regulation ID1 BMP7 17509151 1999738 Positive_regulation ID1 BMP7 20011660 2434286 Positive_regulation ID1 BMP7 20974850 1188962 Positive_regulation ID1 BMP7 22540193 244967 Positive_regulation ID1 BMP7 22540193 245016 Positive_regulation ID1 BMP7 22540193 245025 Positive_regulation ID1 BMP7 22573038 555543 Positive_regulation ID1 BMP7 22964636 2148560 Positive_regulation ID1 BMP7 23675417 2792560 Positive_regulation ID1 BMP7 23675417 2792826 Positive_regulation ID1 BMP7 24116187 2865739 Positive_regulation ID1 BMP7 24116187 2865763 Positive_regulation ID1 BMP7 24116187 2865768 Positive_regulation ID1 BMP7 24116187 2865772 Positive_regulation ID1 BMP7 24160469 1870161 Positive_regulation ID1 BMP7 24224048 2878004 Positive_regulation ID1 BMP7 24227947 1716248 Positive_regulation ID1 BMP7 24347544 752254 Positive_regulation ID1 BMP7 24508480 699138 Positive_regulation ID1 BMP7 24554596 2212965 Positive_regulation ID1 BMP7 24554596 2212966 Positive_regulation ID1 BMP7 24554596 2213106 Positive_regulation ID1 BMP7 24850914 2213446 Positive_regulation ID1 BMP7 25010525 3068585 Positive_regulation ID1 BMP7 25010525 3068633 Positive_regulation ID1 BMP7 PMC3332507 134888 Positive_regulation ID1 BMPR1A 17509151 1999796 Positive_regulation ID1 BMPR1A 20187934 1676852 Positive_regulation ID1 BMPR1A 22916109 2680015 Positive_regulation ID1 BMPR1A 23593444 2781403 Positive_regulation ID1 BMPR1A 23593444 2781405 Positive_regulation ID1 BTG2 24744701 869121 Positive_regulation ID1 CALM3 17183645 2373622 Positive_regulation ID1 CD79A 22204395 262994 Positive_regulation ID1 CD79B 22204395 262995 Positive_regulation ID1 CDH6 24069422 2853341 Positive_regulation ID1 CDKN1A 23517130 268088 Positive_regulation ID1 CXCL12 24256728 1991134 Positive_regulation ID1 CXCL12 24256728 1991151 Positive_regulation ID1 CXCL12 24256728 1991160 Positive_regulation ID1 EGF 25028095 1875744 Positive_regulation ID1 EGF 25028095 1875783 Positive_regulation ID1 EGF 25028095 1875784 Positive_regulation ID1 FOXO3 20565867 1856216 Positive_regulation ID1 FOXO3 20565867 1856219 Positive_regulation ID1 GDF2 23669347 1034165 Positive_regulation ID1 GDF2 23669347 1034166 Positive_regulation ID1 GDF2 23669347 1034167 Positive_regulation ID1 GDF2 23977991 220735 Positive_regulation ID1 GDF2 24670474 1125585 Positive_regulation ID1 GDF2 25393508 1134137 Positive_regulation ID1 GDF3 20950440 1504585 Positive_regulation ID1 GSPT1 25028095 1875730 Positive_regulation ID1 GSPT1 25028095 1875741 Positive_regulation ID1 GSPT1 25028095 1875752 Positive_regulation ID1 GSPT1 25028095 1875760 Positive_regulation ID1 GSPT1 25028095 1875793 Positive_regulation ID1 GSPT1 25028095 1875800 Positive_regulation ID1 HEY1 19855400 1960858 Positive_regulation ID1 ID3 PMC3329082 3086540 Positive_regulation ID1 KLF17 19951400 1006923 Positive_regulation ID1 KRT27 24705254 1951702 Positive_regulation ID1 MAGEA1 21876767 2547460 Positive_regulation ID1 MAP3K7 19536134 764656 Positive_regulation ID1 MCAM 22272201 1067122 Positive_regulation ID1 MET PMC4053215 477165 Positive_regulation ID1 MYLIP 22821565 2079795 Positive_regulation ID1 NOTCH1 19508709 1850853 Positive_regulation ID1 NOTCH1 19508709 1850865 Positive_regulation ID1 NOTCH1 19508709 1850885 Positive_regulation ID1 NOTCH1 19508709 1850909 Positive_regulation ID1 NOTCH1 24950189 2982052 Positive_regulation ID1 NOTCH1 24950189 2982085 Positive_regulation ID1 NOTCH2 19508709 1850854 Positive_regulation ID1 NOTCH2 19508709 1850866 Positive_regulation ID1 NOTCH2 19508709 1850886 Positive_regulation ID1 NOTCH2 19508709 1850910 Positive_regulation ID1 NOTCH2 24950189 2982053 Positive_regulation ID1 NOTCH2 24950189 2982086 Positive_regulation ID1 NOTCH3 19508709 1850855 Positive_regulation ID1 NOTCH3 19508709 1850867 Positive_regulation ID1 NOTCH3 19508709 1850887 Positive_regulation ID1 NOTCH3 19508709 1850911 Positive_regulation ID1 NOTCH3 24950189 2982054 Positive_regulation ID1 NOTCH3 24950189 2982087 Positive_regulation ID1 NOTCH4 19508709 1850856 Positive_regulation ID1 NOTCH4 19508709 1850868 Positive_regulation ID1 NOTCH4 19508709 1850888 Positive_regulation ID1 NOTCH4 19508709 1850912 Positive_regulation ID1 NOTCH4 24950189 2982055 Positive_regulation ID1 NOTCH4 24950189 2982088 Positive_regulation ID1 PDLIM7 20565867 1856130 Positive_regulation ID1 PDLIM7 20565867 1856131 Positive_regulation ID1 PDLIM7 20565867 1856132 Positive_regulation ID1 PDLIM7 20565867 1856133 Positive_regulation ID1 PDLIM7 20565867 1856134 Positive_regulation ID1 PDLIM7 20565867 1856135 Positive_regulation ID1 PDLIM7 20565867 1856138 Positive_regulation ID1 PDLIM7 20565867 1856139 Positive_regulation ID1 PDLIM7 20565867 1856199 Positive_regulation ID1 PDLIM7 20565867 1856200 Positive_regulation ID1 PDLIM7 20565867 1856213 Positive_regulation ID1 PDLIM7 20565867 1856234 Positive_regulation ID1 PDLIM7 20565867 1856264 Positive_regulation ID1 PDLIM7 20565867 1856265 Positive_regulation ID1 PDLIM7 25010525 3068575 Positive_regulation ID1 PIK3CA 22139302 1879365 Positive_regulation ID1 PIK3CA 22139302 1879405 Positive_regulation ID1 PIK3CA 22139302 1879418 Positive_regulation ID1 PIK3CA 22139302 1879453 Positive_regulation ID1 PIK3R1 22139302 1879366 Positive_regulation ID1 PIK3R1 22139302 1879406 Positive_regulation ID1 PIK3R1 22139302 1879419 Positive_regulation ID1 PIK3R1 22139302 1879454 Positive_regulation ID1 PRKACB 23166790 2719169 Positive_regulation ID1 PRKACG 23166790 2719170 Positive_regulation ID1 PRKAR1A 23166790 2719171 Positive_regulation ID1 PRKAR1B 23166790 2719172 Positive_regulation ID1 PRKAR2A 23166790 2719173 Positive_regulation ID1 PRKAR2B 23166790 2719174 Positive_regulation ID1 PTGS2 24659686 2188435 Positive_regulation ID1 PTGS2 24659686 2188436 Positive_regulation ID1 PTGS2 24659686 2188437 Positive_regulation ID1 PTGS2 24659686 2188438 Positive_regulation ID1 SETD2 20003244 254760 Positive_regulation ID1 SLC22A3 23555842 2775523 Positive_regulation ID1 SLC22A3 24970809 2193984 Positive_regulation ID1 SMAD1 21996749 2144128 Positive_regulation ID1 SMAD1 22348410 174960 Positive_regulation ID1 SMAD1 22748179 336976 Positive_regulation ID1 SMAD1 23028567 2691338 Positive_regulation ID1 SMAD1 24760515 2252008 Positive_regulation ID1 SMAD1 25010525 3068543 Positive_regulation ID1 SMAD1 25534700 3148990 Positive_regulation ID1 SMAD2 22348410 174961 Positive_regulation ID1 SMAD3 20565867 1856136 Positive_regulation ID1 SMAD3 22348410 174962 Positive_regulation ID1 SMAD3 22509103 1914183 Positive_regulation ID1 SMAD4 20974850 1188963 Positive_regulation ID1 SMAD4 22348410 174963 Positive_regulation ID1 SMAD4 24554596 2213108 Positive_regulation ID1 SMAD5 21996749 2144129 Positive_regulation ID1 SMAD5 22348410 174964 Positive_regulation ID1 SMAD5 22748179 336977 Positive_regulation ID1 SMAD5 23028567 2691339 Positive_regulation ID1 SMAD5 24760515 2252009 Positive_regulation ID1 SMAD6 22348410 174965 Positive_regulation ID1 SMAD7 22348410 174966 Positive_regulation ID1 SMAD9 22348410 174967 Positive_regulation ID1 SRC 24457967 571677 Positive_regulation ID1 STMN3 25028095 1875729 Positive_regulation ID1 STMN3 25028095 1875740 Positive_regulation ID1 STMN3 25028095 1875751 Positive_regulation ID1 STMN3 25028095 1875759 Positive_regulation ID1 STMN3 25028095 1875792 Positive_regulation ID1 STMN3 25028095 1875799 Positive_regulation ID1 TAB1 19536134 764655 Positive_regulation ID1 TCF12 20565867 1856204 Positive_regulation ID1 TCF12 21765909 2536226 Positive_regulation ID1 TCF15 20565867 1856205 Positive_regulation ID1 TCF15 21765909 2536227 Positive_regulation ID1 TCF19 20565867 1856206 Positive_regulation ID1 TCF19 21765909 2536228 Positive_regulation ID1 TCF20 20565867 1856207 Positive_regulation ID1 TCF20 21765909 2536229 Positive_regulation ID1 TCF21 20565867 1856208 Positive_regulation ID1 TCF21 21765909 2536230 Positive_regulation ID1 TCF23 20565867 1856212 Positive_regulation ID1 TCF23 21765909 2536234 Positive_regulation ID1 TCF24 20565867 1856215 Positive_regulation ID1 TCF24 21765909 2536236 Positive_regulation ID1 TCF25 20565867 1856214 Positive_regulation ID1 TCF25 21765909 2536235 Positive_regulation ID1 TCF3 20565867 1856209 Positive_regulation ID1 TCF3 21765909 2536231 Positive_regulation ID1 TCF4 20565867 1856210 Positive_regulation ID1 TCF4 21765909 2536232 Positive_regulation ID1 TCF7 20565867 1856211 Positive_regulation ID1 TCF7 21765909 2536233 Positive_regulation ID1 TMPRSS6 24376517 2901018 Positive_regulation ID1 TNF 24620998 132063 Positive_regulation ID1 TNF 24620998 132067 Positive_regulation ID1 TP53 16966095 792741 Positive_regulation ID1 TP53 24438529 346360 Positive_regulation ID1 VEGFA 16594992 274381 Positive_regulation ID1 VEGFA 22139302 1879329 Positive_regulation ID1 VEGFA 22139302 1879401 Positive_regulation ID1 VEGFA 22139302 1879414 Positive_regulation ID1 VEGFA 22139302 1879432 Positive_regulation ID2 CCND1 22835384 624963 Positive_regulation ID2 CCND1 22835384 624966 Positive_regulation ID2 FAS 17565694 320403 Positive_regulation ID2 IL1B PMC2834047 134477 Positive_regulation ID3 EPHB2 11560990 1520822 Positive_regulation ID3 EPHB2 20062533 2436768 Positive_regulation ID3 FAS 17565694 320404 Positive_regulation ID3 ID1 23342268 491920 Positive_regulation ID3 ID1 PMC3329082 3086541 Positive_regulation ID4 ID1 24904883 452941 Positive_regulation IDDM10 TNF 8064245 1593959 Positive_regulation IDDM11 TNF 8064245 1593960 Positive_regulation IDDM12 TNF 8064245 1593961 Positive_regulation IDDM13 TNF 8064245 1593962 Positive_regulation IDDM14 TNF 8064245 1593963 Positive_regulation IDDM15 TNF 8064245 1593964 Positive_regulation IDDM16 TNF 8064245 1593965 Positive_regulation IDDM17 TNF 8064245 1593966 Positive_regulation IDDM18 TNF 8064245 1593967 Positive_regulation IDDM2 TNF 8064245 1593968 Positive_regulation IDDM3 TNF 8064245 1593969 Positive_regulation IDDM4 TNF 8064245 1593970 Positive_regulation IDDM5 TNF 8064245 1593971 Positive_regulation IDDM6 TNF 8064245 1593972 Positive_regulation IDDM7 TNF 8064245 1593973 Positive_regulation IDDM8 TNF 8064245 1593974 Positive_regulation IDDM9 TNF 8064245 1593975 Positive_regulation IDH3A PGC 19435887 1165961 Positive_regulation IDH3B PGC 19435887 1165962 Positive_regulation IDH3G PGC 19435887 1165963 Positive_regulation IDO1 CCL17 24592266 911273 Positive_regulation IDO1 TLR7 22593757 900796 Positive_regulation IDO1 TLR7 22708060 4562 Positive_regulation IDO1 TLR7 24455433 3151206 Positive_regulation IDO1 TLR7 PMC2767783 3125187 Positive_regulation IDO1 TMEM100 24987708 1622057 Positive_regulation IDO1 TMEM156 24987708 1622075 Positive_regulation IDO1 TMEM211 24987708 1622155 Positive_regulation IDO1 TMEM213 24987708 1622092 Positive_regulation IDO1 TNF 18062806 321222 Positive_regulation IDO1 TNF 18466643 110721 Positive_regulation IDO1 TNF 21810259 1659110 Positive_regulation IDO1 TNF 22837645 1145303 Positive_regulation IDO1 TNF 23882269 908246 Positive_regulation IDO1 TNF 24147117 2869673 Positive_regulation IDO1 TNF 24561546 1736129 Positive_regulation IDO1 TNF 24567701 938656 Positive_regulation IDO1 TNF 24567701 938681 Positive_regulation IDO1 TNF 25003339 2986963 Positive_regulation IDO1 TNF 25123797 368551 Positive_regulation IDO1 TNF 25237578 1150249 Positive_regulation IDO2 TLR7 24455433 3151205 Positive_regulation IDO2 TNF 18062806 321218 Positive_regulation IER3 EPHB2 23704935 2796657 Positive_regulation IER3 EPHB2 23704935 2796677 Positive_regulation IER3 TNF 19570030 137526 Positive_regulation IFFO1 MUC16 22163280 2578050 Positive_regulation IFI16 TLR7 25276842 1623288 Positive_regulation IFI27 ABL1 14680481 457988 Positive_regulation IFI27 ABL1 20200561 1719546 Positive_regulation IFI27 ABL1 24098519 2857941 Positive_regulation IFI27 ABL1 24098519 2857991 Positive_regulation IFI27 ADPRH 21836819 648250 Positive_regulation IFI27 AKT1 16780593 579932 Positive_regulation IFI27 AKT1 16780593 579933 Positive_regulation IFI27 AKT1 17407586 1846424 Positive_regulation IFI27 AKT1 20170512 481460 Positive_regulation IFI27 AKT1 20200561 1719543 Positive_regulation IFI27 AKT1 21841827 2141889 Positive_regulation IFI27 AKT1 22466454 30585 Positive_regulation IFI27 AKT1 22733130 2147498 Positive_regulation IFI27 AKT1 22733130 2147650 Positive_regulation IFI27 AKT1 22830017 623067 Positive_regulation IFI27 AKT1 23300741 2735808 Positive_regulation IFI27 AKT1 23300741 2735818 Positive_regulation IFI27 AKT1 23383273 2749921 Positive_regulation IFI27 AKT1 23819440 3113722 Positive_regulation IFI27 AKT1 24457952 571277 Positive_regulation IFI27 AKT1 24481416 2012024 Positive_regulation IFI27 AKT1 24759584 137090 Positive_regulation IFI27 AKT1 25533015 2119302 Positive_regulation IFI27 AKT2 16780593 579934 Positive_regulation IFI27 AKT2 17407586 1846425 Positive_regulation IFI27 AKT2 20170512 481461 Positive_regulation IFI27 AKT2 20200561 1719544 Positive_regulation IFI27 AKT2 21297943 2498619 Positive_regulation IFI27 AKT2 21841827 2141890 Positive_regulation IFI27 AKT2 22466454 30586 Positive_regulation IFI27 AKT2 22733130 2147499 Positive_regulation IFI27 AKT2 22733130 2147651 Positive_regulation IFI27 AKT2 22830017 623068 Positive_regulation IFI27 AKT2 23300741 2735809 Positive_regulation IFI27 AKT2 23383273 2749922 Positive_regulation IFI27 AKT2 23819440 3113723 Positive_regulation IFI27 AKT2 24457952 571278 Positive_regulation IFI27 AKT2 24481416 2012025 Positive_regulation IFI27 AKT2 24759584 137091 Positive_regulation IFI27 AKT2 25533015 2119303 Positive_regulation IFI27 AKT3 16780593 579935 Positive_regulation IFI27 AKT3 17407586 1846426 Positive_regulation IFI27 AKT3 20170512 481462 Positive_regulation IFI27 AKT3 20200561 1719545 Positive_regulation IFI27 AKT3 21841827 2141891 Positive_regulation IFI27 AKT3 21869924 798834 Positive_regulation IFI27 AKT3 22466454 30587 Positive_regulation IFI27 AKT3 22733130 2147500 Positive_regulation IFI27 AKT3 22733130 2147652 Positive_regulation IFI27 AKT3 22830017 623069 Positive_regulation IFI27 AKT3 23300741 2735810 Positive_regulation IFI27 AKT3 23383273 2749923 Positive_regulation IFI27 AKT3 23819440 3113724 Positive_regulation IFI27 AKT3 24457952 571279 Positive_regulation IFI27 AKT3 24481416 2012026 Positive_regulation IFI27 AKT3 24759584 137092 Positive_regulation IFI27 AKT3 25533015 2119304 Positive_regulation IFI27 APC 21552325 3051761 Positive_regulation IFI27 APC 23029392 2697065 Positive_regulation IFI27 APC 23029392 2697141 Positive_regulation IFI27 APC 24502434 833965 Positive_regulation IFI27 APOBEC3G 23890083 378432 Positive_regulation IFI27 ATOH1 23409082 2753490 Positive_regulation IFI27 BCL10 19356250 3117713 Positive_regulation IFI27 BCL10 23974114 544505 Positive_regulation IFI27 BCL2 16839413 249514 Positive_regulation IFI27 BCL2 16839413 249519 Positive_regulation IFI27 BCL2 23974114 544506 Positive_regulation IFI27 BCL3 23974114 544507 Positive_regulation IFI27 BCL5 23974114 544502 Positive_regulation IFI27 BCL6 23974114 544503 Positive_regulation IFI27 BCL9 23974114 544504 Positive_regulation IFI27 BCR 14680481 457985 Positive_regulation IFI27 BCR 20200561 1719540 Positive_regulation IFI27 BCR 21244694 527087 Positive_regulation IFI27 BCR 24098519 2857939 Positive_regulation IFI27 BCR 24098519 2857989 Positive_regulation IFI27 BPIFA1 23472073 2763825 Positive_regulation IFI27 BST2 23853598 3063073 Positive_regulation IFI27 BTRC 25271736 3011908 Positive_regulation IFI27 CA8 24870804 2975256 Positive_regulation IFI27 CASP1 17986353 461832 Positive_regulation IFI27 CASP1 19669214 1619249 Positive_regulation IFI27 CASP1 21738161 1961553 Positive_regulation IFI27 CASP1 23386784 176166 Positive_regulation IFI27 CASP10 17986353 461833 Positive_regulation IFI27 CASP10 23386784 176167 Positive_regulation IFI27 CASP12 17986353 461843 Positive_regulation IFI27 CASP12 23386784 176177 Positive_regulation IFI27 CASP14 17986353 461834 Positive_regulation IFI27 CASP14 23386784 176168 Positive_regulation IFI27 CASP16 17986353 461844 Positive_regulation IFI27 CASP16 23386784 176178 Positive_regulation IFI27 CASP2 17986353 461835 Positive_regulation IFI27 CASP2 23386784 176169 Positive_regulation IFI27 CASP3 17986353 461836 Positive_regulation IFI27 CASP3 18725974 2395783 Positive_regulation IFI27 CASP3 20453882 2132153 Positive_regulation IFI27 CASP3 23386784 176170 Positive_regulation IFI27 CASP3 23449448 560453 Positive_regulation IFI27 CASP4 17986353 461837 Positive_regulation IFI27 CASP4 23386784 176171 Positive_regulation IFI27 CASP5 17986353 461838 Positive_regulation IFI27 CASP5 23386784 176172 Positive_regulation IFI27 CASP6 17986353 461839 Positive_regulation IFI27 CASP6 23386784 176173 Positive_regulation IFI27 CASP7 17986353 461840 Positive_regulation IFI27 CASP7 23386784 176174 Positive_regulation IFI27 CASP8 17986353 461841 Positive_regulation IFI27 CASP8 23386784 176175 Positive_regulation IFI27 CASP9 17986353 461842 Positive_regulation IFI27 CASP9 23386784 176176 Positive_regulation IFI27 CCDC19 24976536 1483664 Positive_regulation IFI27 CCDC19 24976536 1483689 Positive_regulation IFI27 CCNA2 18544709 706265 Positive_regulation IFI27 CCNB1 23006512 1698862 Positive_regulation IFI27 CCND1 11250701 455660 Positive_regulation IFI27 CCND1 21677822 641225 Positive_regulation IFI27 CCND1 23006512 1698863 Positive_regulation IFI27 CCND1 23843843 1238249 Positive_regulation IFI27 CCND1 24098526 2858086 Positive_regulation IFI27 CCND1 25109503 3114694 Positive_regulation IFI27 CCND1 25486097 3032736 Positive_regulation IFI27 CCND2 11250701 455661 Positive_regulation IFI27 CCND2 22577380 1072984 Positive_regulation IFI27 CCND3 23907123 543969 Positive_regulation IFI27 CCNE1 22417103 587253 Positive_regulation IFI27 CCNT1 20492666 1855382 Positive_regulation IFI27 CD79A 20200561 1719541 Positive_regulation IFI27 CD79A 21244694 527088 Positive_regulation IFI27 CD79B 20200561 1719542 Positive_regulation IFI27 CD79B 21244694 527089 Positive_regulation IFI27 CDC34 19384426 668878 Positive_regulation IFI27 CDH1 23029392 2697139 Positive_regulation IFI27 CDH1 24502434 833964 Positive_regulation IFI27 CDH1 9679152 1469027 Positive_regulation IFI27 CDK16 25593992 2172359 Positive_regulation IFI27 CDK2 20492666 1855383 Positive_regulation IFI27 CDK2 20975996 2478741 Positive_regulation IFI27 CDK2 22417103 587254 Positive_regulation IFI27 CDK2 22918246 541823 Positive_regulation IFI27 CDK2 23006512 1698864 Positive_regulation IFI27 CDK2 23843843 1238250 Positive_regulation IFI27 CDK4 22577380 1072985 Positive_regulation IFI27 CDK4 23843843 1238251 Positive_regulation IFI27 CDK4 25486097 3032737 Positive_regulation IFI27 CDK5 21566658 547255 Positive_regulation IFI27 CDK5 25520935 203484 Positive_regulation IFI27 CDK7 24511319 825184 Positive_regulation IFI27 CDK9 20492666 1855384 Positive_regulation IFI27 CDKN1A 17088910 428321 Positive_regulation IFI27 CDKN1A 17088910 428322 Positive_regulation IFI27 CDKN1A 17088910 428353 Positive_regulation IFI27 CDKN1A 17088910 428374 Positive_regulation IFI27 CDKN1A 19267931 3109319 Positive_regulation IFI27 CDKN1A 21986579 13542 Positive_regulation IFI27 CDKN1A 22242193 2587434 Positive_regulation IFI27 CDKN1A 24358021 2285077 Positive_regulation IFI27 CDKN1A 24401087 271095 Positive_regulation IFI27 CDKN1B 22918246 541824 Positive_regulation IFI27 CFL1 23509459 1073479 Positive_regulation IFI27 CIB1 15603588 277979 Positive_regulation IFI27 CIB1 19343060 7163 Positive_regulation IFI27 CKS1B 21677822 641226 Positive_regulation IFI27 CKS1B 22898779 700287 Positive_regulation IFI27 CKS1B 23029392 2697099 Positive_regulation IFI27 CNR1 21346174 717973 Positive_regulation IFI27 CNTN2 17535428 3116557 Positive_regulation IFI27 CNTN2 19356250 3117695 Positive_regulation IFI27 CNTN2 19356250 3117696 Positive_regulation IFI27 CNTN2 19356250 3117711 Positive_regulation IFI27 CNTN2 21552325 3051781 Positive_regulation IFI27 CNTN2 21552325 3051789 Positive_regulation IFI27 CNTN2 21552325 3051790 Positive_regulation IFI27 CRTC2 24759584 137089 Positive_regulation IFI27 CUL1 19384426 668879 Positive_regulation IFI27 CUL1 22558406 2625579 Positive_regulation IFI27 CUL1 25271736 3011909 Positive_regulation IFI27 CYP1A1 24351910 1730470 Positive_regulation IFI27 DAP 17088910 428323 Positive_regulation IFI27 DAP 17088910 428324 Positive_regulation IFI27 DAP 17088910 428339 Positive_regulation IFI27 DAP 17088910 428361 Positive_regulation IFI27 DAP 17088910 428362 Positive_regulation IFI27 DCAF7 21328542 775883 Positive_regulation IFI27 DND1 23890083 378410 Positive_regulation IFI27 DND1 23890083 378434 Positive_regulation IFI27 E2F1 24976536 1483665 Positive_regulation IFI27 E2F1 24976536 1483690 Positive_regulation IFI27 EGF 23919615 290092 Positive_regulation IFI27 EGFR 14680481 457986 Positive_regulation IFI27 EGFR 23829771 410494 Positive_regulation IFI27 EGR2 14757751 1305473 Positive_regulation IFI27 EPHB2 21114830 403440 Positive_regulation IFI27 EPHB2 23029392 2697060 Positive_regulation IFI27 EPHB2 23029392 2697150 Positive_regulation IFI27 EPHB2 23237773 2181999 Positive_regulation IFI27 EPHB2 23762493 2804199 Positive_regulation IFI27 ERBB2 14680481 457987 Positive_regulation IFI27 ERBB2 17129383 460145 Positive_regulation IFI27 ESR1 23351343 695279 Positive_regulation IFI27 EVPL 24098519 2857940 Positive_regulation IFI27 EVPL 24098519 2857990 Positive_regulation IFI27 EZH2 21765901 2536186 Positive_regulation IFI27 FARP2 24811221 2190582 Positive_regulation IFI27 FGF1 12177046 1286089 Positive_regulation IFI27 FGF10 12177046 1286090 Positive_regulation IFI27 FGF11 12177046 1286091 Positive_regulation IFI27 FGF12 12177046 1286092 Positive_regulation IFI27 FGF13 12177046 1286093 Positive_regulation IFI27 FGF14 12177046 1286094 Positive_regulation IFI27 FGF16 12177046 1286095 Positive_regulation IFI27 FGF17 12177046 1286096 Positive_regulation IFI27 FGF18 12177046 1286097 Positive_regulation IFI27 FGF19 12177046 1286098 Positive_regulation IFI27 FGF2 12177046 1286099 Positive_regulation IFI27 FGF20 12177046 1286100 Positive_regulation IFI27 FGF21 12177046 1286101 Positive_regulation IFI27 FGF22 12177046 1286102 Positive_regulation IFI27 FGF23 12177046 1286103 Positive_regulation IFI27 FGF3 12177046 1286104 Positive_regulation IFI27 FGF4 12177046 1286105 Positive_regulation IFI27 FGF5 12177046 1286106 Positive_regulation IFI27 FGF6 12177046 1286107 Positive_regulation IFI27 FGF7 12177046 1286108 Positive_regulation IFI27 FGF8 12177046 1286109 Positive_regulation IFI27 FGF9 12177046 1286110 Positive_regulation IFI27 FOXO1 21957439 2557173 Positive_regulation IFI27 FOXO1 24112473 270048 Positive_regulation IFI27 FOXO1 24457952 571275 Positive_regulation IFI27 FOXO1 24741631 1621413 Positive_regulation IFI27 FOXO3 11815629 1278647 Positive_regulation IFI27 FOXO3 14734530 1304600 Positive_regulation IFI27 FOXO3 20504360 256061 Positive_regulation IFI27 FOXO3 20661471 2456699 Positive_regulation IFI27 FOXO3 21179458 2488080 Positive_regulation IFI27 FOXO3 21957439 2557174 Positive_regulation IFI27 FOXO3 23259070 1719098 Positive_regulation IFI27 FOXO3 23691078 2794269 Positive_regulation IFI27 FOXO3 23691078 2794282 Positive_regulation IFI27 FOXO3 23691078 2794298 Positive_regulation IFI27 FOXO3 23840429 2812814 Positive_regulation IFI27 FOXO3 23907123 543974 Positive_regulation IFI27 FOXO3 24457952 571276 Positive_regulation IFI27 FOXO4 21957439 2557175 Positive_regulation IFI27 FOXO4 24457952 571280 Positive_regulation IFI27 FOXO6 21957439 2557172 Positive_regulation IFI27 FOXO6 24457952 571274 Positive_regulation IFI27 GOT2 23077520 2704721 Positive_regulation IFI27 GPR3 19526062 2419430 Positive_regulation IFI27 GRN 20492666 1855385 Positive_regulation IFI27 GSTM3 25202346 2169607 Positive_regulation IFI27 HEPACAM 20226097 411792 Positive_regulation IFI27 HES1 23365582 3173823 Positive_regulation IFI27 HGF 22028694 956084 Positive_regulation IFI27 HGF 24426773 1916680 Positive_regulation IFI27 HRAS 14680481 458090 Positive_regulation IFI27 HRAS 20414333 1672117 Positive_regulation IFI27 IAPP 17088910 428346 Positive_regulation IFI27 IARS 20622167 715505 Positive_regulation IFI27 ID3 18069898 2304637 Positive_regulation IFI27 ID3 18069898 2304645 Positive_regulation IFI27 ID3 18069898 2304652 Positive_regulation IFI27 ID3 18069898 2304655 Positive_regulation IFI27 ID3 23342268 491921 Positive_regulation IFI27 IFNG 23940519 2831307 Positive_regulation IFI27 IGFBP7 23388612 660397 Positive_regulation IFI27 IL2 12107831 421836 Positive_regulation IFI27 IL2 15059264 100901 Positive_regulation IFI27 IL4 8760794 1598714 Positive_regulation IFI27 IL6 15583018 1533982 Positive_regulation IFI27 IL8 25165728 1623142 Positive_regulation IFI27 IRF9 24065129 773309 Positive_regulation IFI27 JUN 21892199 13280 Positive_regulation IFI27 JUN 24976536 1483666 Positive_regulation IFI27 JUN 24976536 1483691 Positive_regulation IFI27 KAT2B 22547391 2074910 Positive_regulation IFI27 KAT2B 22547391 2074918 Positive_regulation IFI27 KAT2B 22547391 2074925 Positive_regulation IFI27 KAT2B 22547391 2074930 Positive_regulation IFI27 KIN 25120685 2169295 Positive_regulation IFI27 KITLG 10555750 415536 Positive_regulation IFI27 KITLG 24788701 2959235 Positive_regulation IFI27 KMT2A 22916108 2679997 Positive_regulation IFI27 KMT2A 25267403 612944 Positive_regulation IFI27 KRAS 14680481 458091 Positive_regulation IFI27 KRAS 20414333 1672118 Positive_regulation IFI27 LBH 24093956 1869844 Positive_regulation IFI27 LGALS3 24971481 548968 Positive_regulation IFI27 LGALS3 24971481 548969 Positive_regulation IFI27 LGALS3 24971481 548993 Positive_regulation IFI27 MALT1 19356250 3117712 Positive_regulation IFI27 MAP2K1 21114830 403441 Positive_regulation IFI27 MAP2K2 21114830 403442 Positive_regulation IFI27 MAP2K3 21114830 403443 Positive_regulation IFI27 MAP2K4 21114830 403444 Positive_regulation IFI27 MAP2K5 21114830 403445 Positive_regulation IFI27 MAP2K6 21114830 403446 Positive_regulation IFI27 MAP2K7 21114830 403447 Positive_regulation IFI27 MAPK1 11560992 1520860 Positive_regulation IFI27 MAPK1 20414333 1672119 Positive_regulation IFI27 MAPK1 23029392 2697066 Positive_regulation IFI27 MAPK10 11560992 1520861 Positive_regulation IFI27 MAPK10 20414333 1672120 Positive_regulation IFI27 MAPK10 23029392 2697067 Positive_regulation IFI27 MAPK11 11560992 1520862 Positive_regulation IFI27 MAPK11 20414333 1672121 Positive_regulation IFI27 MAPK11 23029392 2697068 Positive_regulation IFI27 MAPK12 11560992 1520863 Positive_regulation IFI27 MAPK12 20414333 1672122 Positive_regulation IFI27 MAPK12 23029392 2697069 Positive_regulation IFI27 MAPK13 11560992 1520864 Positive_regulation IFI27 MAPK13 20414333 1672123 Positive_regulation IFI27 MAPK13 23029392 2697070 Positive_regulation IFI27 MAPK14 11560992 1520865 Positive_regulation IFI27 MAPK14 20414333 1672124 Positive_regulation IFI27 MAPK14 23029392 2697071 Positive_regulation IFI27 MAPK15 11560992 1520859 Positive_regulation IFI27 MAPK15 20414333 1672116 Positive_regulation IFI27 MAPK15 23029392 2697064 Positive_regulation IFI27 MAPK3 11560992 1520866 Positive_regulation IFI27 MAPK3 12935295 1843622 Positive_regulation IFI27 MAPK3 20414333 1672125 Positive_regulation IFI27 MAPK3 23029392 2697072 Positive_regulation IFI27 MAPK3 23476673 1144027 Positive_regulation IFI27 MAPK3 23762493 2804200 Positive_regulation IFI27 MAPK4 11560992 1520867 Positive_regulation IFI27 MAPK4 20414333 1672126 Positive_regulation IFI27 MAPK4 23029392 2697073 Positive_regulation IFI27 MAPK6 11560992 1520868 Positive_regulation IFI27 MAPK6 20414333 1672127 Positive_regulation IFI27 MAPK6 23029392 2697074 Positive_regulation IFI27 MAPK7 11560992 1520869 Positive_regulation IFI27 MAPK7 20414333 1672128 Positive_regulation IFI27 MAPK7 23029392 2697075 Positive_regulation IFI27 MAPK8 11560992 1520870 Positive_regulation IFI27 MAPK8 20414333 1672129 Positive_regulation IFI27 MAPK8 23029392 2697076 Positive_regulation IFI27 MAPK9 11560992 1520871 Positive_regulation IFI27 MAPK9 20414333 1672130 Positive_regulation IFI27 MAPK9 23029392 2697077 Positive_regulation IFI27 MLST8 22733130 2147496 Positive_regulation IFI27 MLST8 22733130 2147619 Positive_regulation IFI27 MLST8 22733130 2147640 Positive_regulation IFI27 MTOR 20170512 481463 Positive_regulation IFI27 MTOR 22733130 2147501 Positive_regulation IFI27 MTOR 22733130 2147621 Positive_regulation IFI27 MTOR 22733130 2147642 Positive_regulation IFI27 MTOR 23300741 2735811 Positive_regulation IFI27 MTOR 23389114 809958 Positive_regulation IFI27 MUC4 23136569 1713785 Positive_regulation IFI27 MYC 11250701 455662 Positive_regulation IFI27 MYC 24976536 1483667 Positive_regulation IFI27 MYC 24976536 1483692 Positive_regulation IFI27 MYC 25392689 490150 Positive_regulation IFI27 MYLIP 18701644 2035888 Positive_regulation IFI27 MYLIP 20948989 2174558 Positive_regulation IFI27 MYLIP 21909123 13302 Positive_regulation IFI27 MYLIP 22086949 2069448 Positive_regulation IFI27 MYLIP 23409140 2753757 Positive_regulation IFI27 MYLIP 23890083 378433 Positive_regulation IFI27 MYLIP 24137356 2165636 Positive_regulation IFI27 MYLIP 24314651 3216471 Positive_regulation IFI27 MYLIP 24727437 2188824 Positive_regulation IFI27 MYLIP 25435958 2170284 Positive_regulation IFI27 NEDD4 21986318 3079220 Positive_regulation IFI27 NELFCD 24588000 187349 Positive_regulation IFI27 NFATC1 20049729 774445 Positive_regulation IFI27 NFATC1 21148296 1784369 Positive_regulation IFI27 NFATC1 21148296 1784422 Positive_regulation IFI27 NFATC1 22696685 1803912 Positive_regulation IFI27 NFATC4 21148296 1784370 Positive_regulation IFI27 NFATC4 21148296 1784423 Positive_regulation IFI27 NFATC4 22696685 1803913 Positive_regulation IFI27 NME1 19123928 1994576 Positive_regulation IFI27 NME1 19123928 1994654 Positive_regulation IFI27 NOTCH1 25323114 1886966 Positive_regulation IFI27 NOTCH2 25323114 1886967 Positive_regulation IFI27 NOTCH3 25323114 1886968 Positive_regulation IFI27 NOTCH4 25323114 1886969 Positive_regulation IFI27 NR4A1 25269081 3011879 Positive_regulation IFI27 NRAS 14680481 458093 Positive_regulation IFI27 NRAS 20414333 1672131 Positive_regulation IFI27 PARP1 24367566 2900230 Positive_regulation IFI27 PCNA 19383130 525229 Positive_regulation IFI27 PCNA 19457236 463979 Positive_regulation IFI27 PCNA 20492666 1855386 Positive_regulation IFI27 PCNA 23511556 440327 Positive_regulation IFI27 PCNA 23696836 2795382 Positive_regulation IFI27 PCNA 24023847 2843808 Positive_regulation IFI27 PCNA 24083250 184401 Positive_regulation IFI27 PCNA 24886442 3114623 Positive_regulation IFI27 PCNA 25109503 3114695 Positive_regulation IFI27 PDCD4 22272332 2589640 Positive_regulation IFI27 PDIA3 23843843 1238252 Positive_regulation IFI27 PDK1 23300741 2735812 Positive_regulation IFI27 PFKFB3 25032860 577609 Positive_regulation IFI27 PI3 20200561 1719458 Positive_regulation IFI27 PIK3CA 14680481 458019 Positive_regulation IFI27 PIK3CA 16780593 579936 Positive_regulation IFI27 PIK3CA 20170512 481464 Positive_regulation IFI27 PIK3CA 22733130 2147502 Positive_regulation IFI27 PIK3CA 22733130 2147503 Positive_regulation IFI27 PIK3CA 22733130 2147594 Positive_regulation IFI27 PIK3CA 22733130 2147653 Positive_regulation IFI27 PIK3CA 24578720 3177507 Positive_regulation IFI27 PIK3CA 25247710 3009194 Positive_regulation IFI27 PIK3R1 14680481 458020 Positive_regulation IFI27 PIK3R1 16780593 579937 Positive_regulation IFI27 PIK3R1 20170512 481465 Positive_regulation IFI27 PIK3R1 22733130 2147504 Positive_regulation IFI27 PIK3R1 22733130 2147505 Positive_regulation IFI27 PIK3R1 22733130 2147595 Positive_regulation IFI27 PIK3R1 22733130 2147654 Positive_regulation IFI27 PIK3R1 24578720 3177508 Positive_regulation IFI27 PIK3R1 25247710 3009195 Positive_regulation IFI27 PMPCA 21762531 357047 Positive_regulation IFI27 PPP2CA 24307892 980693 Positive_regulation IFI27 PPP2R1A 24307892 980694 Positive_regulation IFI27 PPP2R2B 24307892 980695 Positive_regulation IFI27 PRDX2 17999998 2031390 Positive_regulation IFI27 PRDX2 24157878 568605 Positive_regulation IFI27 PRDX2 24456602 1482908 Positive_regulation IFI27 PRKAA1 17623090 1847647 Positive_regulation IFI27 PRKAA1 22272173 3152490 Positive_regulation IFI27 PRKAA1 22897928 266110 Positive_regulation IFI27 PRKAA1 24710481 618637 Positive_regulation IFI27 PRKAA2 17623090 1847648 Positive_regulation IFI27 PRKAA2 22272173 3152491 Positive_regulation IFI27 PRKAA2 22897928 266111 Positive_regulation IFI27 PRKAA2 24710481 618638 Positive_regulation IFI27 PRKAB1 17623090 1847649 Positive_regulation IFI27 PRKAB1 22272173 3152492 Positive_regulation IFI27 PRKAB1 22897928 266112 Positive_regulation IFI27 PRKAB1 24710481 618639 Positive_regulation IFI27 PRKAB2 17623090 1847650 Positive_regulation IFI27 PRKAB2 22272173 3152493 Positive_regulation IFI27 PRKAB2 22897928 266113 Positive_regulation IFI27 PRKAB2 24710481 618640 Positive_regulation IFI27 PRKAG1 17623090 1847651 Positive_regulation IFI27 PRKAG1 22272173 3152494 Positive_regulation IFI27 PRKAG1 22897928 266114 Positive_regulation IFI27 PRKAG1 24710481 618641 Positive_regulation IFI27 PRKAG2 17623090 1847652 Positive_regulation IFI27 PRKAG2 22272173 3152495 Positive_regulation IFI27 PRKAG2 22897928 266115 Positive_regulation IFI27 PRKAG2 24710481 618642 Positive_regulation IFI27 PTEN 21148296 1784371 Positive_regulation IFI27 PTEN 23472073 2763855 Positive_regulation IFI27 PTEN 23936141 2829499 Positive_regulation IFI27 PTHLH 20876711 716613 Positive_regulation IFI27 QKI 19517016 2418933 Positive_regulation IFI27 QKI 20631256 1779037 Positive_regulation IFI27 RAD1 23075476 472500 Positive_regulation IFI27 RAD17 23075476 472501 Positive_regulation IFI27 RAD18 23075476 472499 Positive_regulation IFI27 RAD21 23075476 472502 Positive_regulation IFI27 RAD50 23075476 472503 Positive_regulation IFI27 RAD51 23075476 472504 Positive_regulation IFI27 RAD52 23075476 472505 Positive_regulation IFI27 RALA 23576547 1813436 Positive_regulation IFI27 RALA 23576547 1813437 Positive_regulation IFI27 RALB 23576547 1813438 Positive_regulation IFI27 RALBP1 23576547 1813439 Positive_regulation IFI27 RALBP1 23576547 1813440 Positive_regulation IFI27 RASSF1 21249150 2493155 Positive_regulation IFI27 RASSF1 21249150 2493165 Positive_regulation IFI27 RASSF1 21249150 2493173 Positive_regulation IFI27 RB1 22666376 2647893 Positive_regulation IFI27 RBL2 22417103 587255 Positive_regulation IFI27 RBX1 19384426 668880 Positive_regulation IFI27 REST 22665064 2147210 Positive_regulation IFI27 RET 23509459 1073480 Positive_regulation IFI27 RHOA 14680481 458092 Positive_regulation IFI27 RHOA 23118862 2711866 Positive_regulation IFI27 RHOA 23181102 842703 Positive_regulation IFI27 RICTOR 22733130 2147497 Positive_regulation IFI27 RICTOR 22733130 2147620 Positive_regulation IFI27 RICTOR 22733130 2147641 Positive_regulation IFI27 RNF112 24359566 1232748 Positive_regulation IFI27 RNU12-2P 25486097 3032735 Positive_regulation IFI27 SCML2 24358021 2285076 Positive_regulation IFI27 SETD2 20514219 672450 Positive_regulation IFI27 SETD2 20706634 2458264 Positive_regulation IFI27 SETD2 21103079 2114978 Positive_regulation IFI27 SETD2 24858415 607106 Positive_regulation IFI27 SF3B1 24811221 2190581 Positive_regulation IFI27 SF3B1 25569246 3037287 Positive_regulation IFI27 SF3B3 23951410 170567 Positive_regulation IFI27 SF3B3 23951410 170568 Positive_regulation IFI27 SFN 23476648 1674518 Positive_regulation IFI27 SKP1 22558406 2625577 Positive_regulation IFI27 SKP1 25271736 3011906 Positive_regulation IFI27 SKP2 11250752 457078 Positive_regulation IFI27 SKP2 11425869 1271731 Positive_regulation IFI27 SKP2 12188931 277026 Positive_regulation IFI27 SKP2 12188931 277027 Positive_regulation IFI27 SKP2 17724117 1343447 Positive_regulation IFI27 SKP2 17724117 1343494 Positive_regulation IFI27 SKP2 17724117 1343495 Positive_regulation IFI27 SKP2 17724117 1343505 Positive_regulation IFI27 SKP2 18268034 1549044 Positive_regulation IFI27 SKP2 20525401 313240 Positive_regulation IFI27 SKP2 21255415 586039 Positive_regulation IFI27 SKP2 21423803 2508400 Positive_regulation IFI27 SKP2 22279619 939613 Positive_regulation IFI27 SKP2 22279619 939645 Positive_regulation IFI27 SKP2 22558406 2625578 Positive_regulation IFI27 SKP2 23029392 2697059 Positive_regulation IFI27 SKP2 23029392 2697098 Positive_regulation IFI27 SKP2 23029392 2697144 Positive_regulation IFI27 SKP2 23077551 2704776 Positive_regulation IFI27 SKP2 23226679 941573 Positive_regulation IFI27 SKP2 23255047 605201 Positive_regulation IFI27 SKP2 23409140 2753792 Positive_regulation IFI27 SKP2 23437233 2756273 Positive_regulation IFI27 SKP2 23720603 3680 Positive_regulation IFI27 SKP2 23974100 544264 Positive_regulation IFI27 SKP2 24083250 184400 Positive_regulation IFI27 SKP2 24971481 548966 Positive_regulation IFI27 SKP2 24971481 548967 Positive_regulation IFI27 SKP2 24971481 548992 Positive_regulation IFI27 SKP2 24971481 549002 Positive_regulation IFI27 SKP2 24971481 549045 Positive_regulation IFI27 SKP2 25000203 2986806 Positive_regulation IFI27 SKP2 25032860 577614 Positive_regulation IFI27 SKP2 25271736 3011907 Positive_regulation IFI27 SOCS1 18534028 463019 Positive_regulation IFI27 SP1 24401087 271084 Positive_regulation IFI27 SRC 23829771 410493 Positive_regulation IFI27 STAT1 24065129 773307 Positive_regulation IFI27 STAT2 24065129 773308 Positive_regulation IFI27 STAT6 24401087 271058 Positive_regulation IFI27 STAT6 24401087 271059 Positive_regulation IFI27 STAT6 24401087 271060 Positive_regulation IFI27 STAT6 24401087 271061 Positive_regulation IFI27 STAT6 24401087 271062 Positive_regulation IFI27 STAT6 24401087 271063 Positive_regulation IFI27 STAT6 24401087 271085 Positive_regulation IFI27 STAT6 24401087 271094 Positive_regulation IFI27 STK11 24710481 618636 Positive_regulation IFI27 TAB2 19356250 3117710 Positive_regulation IFI27 TCF12 24741631 1621377 Positive_regulation IFI27 TCF15 24741631 1621378 Positive_regulation IFI27 TCF19 24741631 1621379 Positive_regulation IFI27 TCF20 24741631 1621380 Positive_regulation IFI27 TCF21 24741631 1621381 Positive_regulation IFI27 TCF23 24741631 1621385 Positive_regulation IFI27 TCF24 24741631 1621387 Positive_regulation IFI27 TCF25 24741631 1621386 Positive_regulation IFI27 TCF3 24741631 1621382 Positive_regulation IFI27 TCF4 24741631 1621383 Positive_regulation IFI27 TCF7 24741631 1621384 Positive_regulation IFI27 TMED7 15603588 277980 Positive_regulation IFI27 TMED7 17088910 428360 Positive_regulation IFI27 TMED7 19267931 3109320 Positive_regulation IFI27 TMED7 19343060 7164 Positive_regulation IFI27 TMED7 21841827 2141906 Positive_regulation IFI27 TMED7 22558406 2625560 Positive_regulation IFI27 TMED7 23029392 2697109 Positive_regulation IFI27 TMED7 23029392 2697140 Positive_regulation IFI27 TMED7 24401087 271096 Positive_regulation IFI27 TMED7 25452716 872541 Positive_regulation IFI27 TNF 17565690 1846539 Positive_regulation IFI27 TNF 17565690 1846550 Positive_regulation IFI27 TNF 23263670 1100100 Positive_regulation IFI27 TNFSF10 24727952 2951765 Positive_regulation IFI27 TNFSF10 24727952 2951770 Positive_regulation IFI27 TNFSF10 24970806 2193917 Positive_regulation IFI27 TNFSF10 24970806 2193918 Positive_regulation IFI27 TNFSF10 24970806 2193921 Positive_regulation IFI27 TP53 21639915 259978 Positive_regulation IFI27 TP53 22272332 2589644 Positive_regulation IFI27 TP53 25371703 656894 Positive_regulation IFI27 TRAF6 19356250 3117708 Positive_regulation IFI27 TSC1 20170512 481459 Positive_regulation IFI27 TXNIP 20584310 465812 Positive_regulation IFI27 TYK2 22723949 2655367 Positive_regulation IFI27 UBE2V1 19356250 3117709 Positive_regulation IFI27 UCA1 24457952 571258 Positive_regulation IFI27 UMOD 21558273 1191382 Positive_regulation IFI27 VDR 17999998 2031376 Positive_regulation IFI27 VDR 20808524 672537 Positive_regulation IFI35 TNFSF10 24978043 2985505 Positive_regulation IFI44 CTGF 19852794 1227774 Positive_regulation IFI44 EPHB2 21909400 2552033 Positive_regulation IFI44 FAS 16818723 1330942 Positive_regulation IFI44 MAP2K6 22864984 616763 Positive_regulation IFI44 MMP28 23688423 313720 Positive_regulation IFI44 MMP28 23688423 314183 Positive_regulation IFI44 MMP7 23688423 313735 Positive_regulation IFI44 MMP7 23688423 314199 Positive_regulation IFI44 TNF 23688423 314178 Positive_regulation IFI44 TNF 24069158 2851531 Positive_regulation IFIH1 TLR7 21079690 3049434 Positive_regulation IFIT1 TNF 23626859 2785155 Positive_regulation IFIT2 EPHB2 21368873 550840 Positive_regulation IFIT2 TNF 19108715 352538 Positive_regulation IFIT2 TNF 23626859 2785156 Positive_regulation IFIT3 TNF 22322095 1882592 Positive_regulation IFIT5 TNF 7519620 1436160 Positive_regulation IFIT5 TNF 7519620 1436166 Positive_regulation IFIT5 TNF 7519620 1436172 Positive_regulation IFIT5 TNF 7519620 1436179 Positive_regulation IFITM1 EPHB2 20847954 1747918 Positive_regulation IFITM1 EPHB2 20847954 1747955 Positive_regulation IFITM2 TNF 17822540 395883 Positive_regulation IFN1@ FAS 22084408 1566087 Positive_regulation IFN1@ SELL 7506267 1435151 Positive_regulation IFN1@ TLR7 19047436 1552951 Positive_regulation IFN1@ TLR7 19624844 116092 Positive_regulation IFN1@ TLR7 20975040 1561041 Positive_regulation IFN1@ TLR7 21994554 3218435 Positive_regulation IFN1@ TLR7 21994626 3219408 Positive_regulation IFN1@ TLR7 21994626 3219409 Positive_regulation IFN1@ TLR7 21994626 3219444 Positive_regulation IFN1@ TLR7 21994626 3219460 Positive_regulation IFN1@ TLR7 21994626 3219505 Positive_regulation IFN1@ TLR7 21994626 3219524 Positive_regulation IFN1@ TLR7 23717310 907021 Positive_regulation IFN1@ TLR7 24058799 1706059 Positive_regulation IFN1@ TLR7 24497833 3066111 Positive_regulation IFN1@ TLR7 24586760 2926312 Positive_regulation IFN1@ TLR7 24586760 2926324 Positive_regulation IFN1@ TLR7 25157202 1761776 Positive_regulation IFN1@ TLR7 25157202 1761777 Positive_regulation IFN1@ TLR7 25203514 3006380 Positive_regulation IFN1@ TLR7 25205049 1920451 Positive_regulation IFN1@ TNF 2258703 1568215 Positive_regulation IFN1@ TNF 2450953 1574922 Positive_regulation IFN1@ TNFSF10 22084408 1566088 Positive_regulation IFNA1 TLR7 17589564 2376611 Positive_regulation IFNA1 TLR7 25356432 87749 Positive_regulation IFNA1 TNF 19476613 113411 Positive_regulation IFNA10 TLR7 17589564 2376612 Positive_regulation IFNA10 TLR7 25356432 87759 Positive_regulation IFNA10 TNF 19476613 113414 Positive_regulation IFNA13 TLR7 17589564 2376613 Positive_regulation IFNA13 TLR7 25356432 87769 Positive_regulation IFNA13 TNF 19476613 113417 Positive_regulation IFNA14 TLR7 17589564 2376614 Positive_regulation IFNA14 TLR7 25356432 87779 Positive_regulation IFNA14 TNF 19476613 113420 Positive_regulation IFNA16 TLR7 17589564 2376615 Positive_regulation IFNA16 TLR7 25356432 87789 Positive_regulation IFNA16 TNF 19476613 113423 Positive_regulation IFNA17 TLR7 17589564 2376616 Positive_regulation IFNA17 TLR7 25356432 87799 Positive_regulation IFNA17 TNF 19476613 113426 Positive_regulation IFNA2 TLR7 17589564 2376617 Positive_regulation IFNA2 TLR7 25356432 87809 Positive_regulation IFNA2 TNF 19476613 113429 Positive_regulation IFNA2 TNF 3049910 1579785 Positive_regulation IFNA21 TLR7 17589564 2376618 Positive_regulation IFNA21 TLR7 25356432 87819 Positive_regulation IFNA21 TNF 19476613 113432 Positive_regulation IFNA4 TLR7 17589564 2376619 Positive_regulation IFNA4 TLR7 25084355 2994386 Positive_regulation IFNA4 TLR7 25356432 87829 Positive_regulation IFNA4 TNF 19476613 113435 Positive_regulation IFNA5 TLR7 17589564 2376620 Positive_regulation IFNA5 TLR7 25356432 87839 Positive_regulation IFNA5 TNF 19476613 113438 Positive_regulation IFNA6 TLR7 17589564 2376621 Positive_regulation IFNA6 TLR7 25356432 87849 Positive_regulation IFNA6 TNF 19476613 113441 Positive_regulation IFNA7 TLR7 17589564 2376622 Positive_regulation IFNA7 TLR7 25356432 87859 Positive_regulation IFNA7 TNF 19476613 113444 Positive_regulation IFNA8 TLR7 17589564 2376623 Positive_regulation IFNA8 TLR7 25356432 87869 Positive_regulation IFNA8 TNF 19476613 113447 Positive_regulation IFNAR1 TNF 21365015 2504971 Positive_regulation IFNB1 EPHB2 22427889 2610574 Positive_regulation IFNB1 IL1B 22039457 2565512 Positive_regulation IFNB1 TLR7 17935622 352048 Positive_regulation IFNB1 TLR7 24270516 1959387 Positive_regulation IFNB1 TNF 20361029 2370711 Positive_regulation IFNB1 TNF 20361029 2370716 Positive_regulation IFNB1 TNF 20361029 2370717 Positive_regulation IFNB1 TNF 3166905 443300 Positive_regulation IFNG FAS 17162364 630560 Positive_regulation IFNG IL1B 24791137 1916888 Positive_regulation IFNG STAT4 18803832 111217 Positive_regulation IFNG STAT4 24062747 909024 Positive_regulation IFNG STAT4 24415943 2355298 Positive_regulation IFNG TLR7 24734221 865078 Positive_regulation IFNG TNF 18475620 1744850 Positive_regulation IFNG TNF 20361029 2370719 Positive_regulation IFNG TNF 20361029 2370721 Positive_regulation IFNG TNF 20361029 2370723 Positive_regulation IFNG TNF 2183871 437505 Positive_regulation IFNG TNF 22235301 2585773 Positive_regulation IFNG TNF 23013558 395945 Positive_regulation IFNG TNF 23091569 2215000 Positive_regulation IFNG TNF 24791137 1916887 Positive_regulation IFNG TNFSF10 24978043 2985509 Positive_regulation IFNG-AS1 STAT4 23720660 907048 Positive_regulation IFNL1 TLR7 24286242 130877 Positive_regulation IFNL1 TLR7 24286242 130930 Positive_regulation IFNL1 TNF 23974516 18471 Positive_regulation IFNL1 TNF 24286242 130913 Positive_regulation IFNL3 TNF 24116050 2865056 Positive_regulation IFNR TNF 10389988 414541 Positive_regulation IFNR TNF 24845203 3142043 Positive_regulation IGF1 ARSG 22194889 2583268 Positive_regulation IGF1 ARSG 22194889 2583269 Positive_regulation IGF1 CCND1 19640308 253898 Positive_regulation IGF1 CCND1 19640308 253900 Positive_regulation IGF1 CCND1 19640308 253902 Positive_regulation IGF1 CCND1 19865540 1088915 Positive_regulation IGF1 CCND1 8896599 1456868 Positive_regulation IGF1 CTGF 23555635 2774666 Positive_regulation IGF1 CTGF 23555635 2774672 Positive_regulation IGF1 EPHB2 12592371 422194 Positive_regulation IGF1 EPHB2 16103225 1323254 Positive_regulation IGF1 EPHB2 19707373 175631 Positive_regulation IGF1 EPHB2 21127754 2120749 Positive_regulation IGF1 EPHB2 21203386 2489699 Positive_regulation IGF1 EPHB2 22693602 2650856 Positive_regulation IGF1 EPHB2 23650573 851708 Positive_regulation IGF1 EPHB2 24282611 2886463 Positive_regulation IGF1 EPHB2 25054279 2991421 Positive_regulation IGF1 FBXO32 23762056 1073571 Positive_regulation IGF1 FOXA1 22879989 2673439 Positive_regulation IGF1 FOXO1 21143873 331759 Positive_regulation IGF1 FOXO1 23614736 830007 Positive_regulation IGF1 FOXO1 23614736 830051 Positive_regulation IGF1 FOXO1 23844554 473446 Positive_regulation IGF1 FOXO1 23844554 473524 Positive_regulation IGF1 FOXO1 23844554 473574 Positive_regulation IGF1 FOXO1 24244197 2352921 Positive_regulation IGF1 FOXO1 24968248 3068304 Positive_regulation IGF1 IGFBP1 11461068 419240 Positive_regulation IGF1 IGFBP1 14668047 830511 Positive_regulation IGF1 IGFBP1 20924377 436054 Positive_regulation IGF1 IGFBP1 22363400 2598822 Positive_regulation IGF1 IGFBP1 23383064 2747721 Positive_regulation IGF1 IGFBP1 24899777 175100 Positive_regulation IGF1 IGFBP1 25218581 3176564 Positive_regulation IGF1 IGFBP1 25218581 3176677 Positive_regulation IGF1 IGFBP1 7514606 1435419 Positive_regulation IGF1 LBP 23894366 2824405 Positive_regulation IGF1 MAP2K6 19707373 175637 Positive_regulation IGF1 MAP2K6 19834495 546442 Positive_regulation IGF1 MAP2K6 24282611 2886469 Positive_regulation IGF1 MMP28 19375502 1731658 Positive_regulation IGF1 PGC 23180446 1239160 Positive_regulation IGF1 SMN2 22669976 1203668 Positive_regulation IGF1 SPHK1 24468113 5987 Positive_regulation IGF1 TM4SF19 25344917 2206322 Positive_regulation IGF1 TNF 14624693 658505 Positive_regulation IGF1 TNF 22997483 1750589 Positive_regulation IGF1 TNF 23271367 1100121 Positive_regulation IGF1 TNF 25013674 1143394 Positive_regulation IGF1 TNFSF10 24885194 1874452 Positive_regulation IGF1 WNT7A 22179044 1928052 Positive_regulation IGF1R ARSA 22761875 2659040 Positive_regulation IGF1R EPHB2 23382729 878036 Positive_regulation IGF1R EPHB2 24384722 570751 Positive_regulation IGF1R FOXO1 23638435 943384 Positive_regulation IGF1R IL1B 25344917 2206199 Positive_regulation IGF1R MAP2K6 21505228 2175854 Positive_regulation IGF1R MAP2K6 22747855 1866208 Positive_regulation IGF1R MAP2K6 23382729 878045 Positive_regulation IGF1R MMP28 25356505 1133673 Positive_regulation IGF1R MMP7 25356505 1133688 Positive_regulation IGF1R SLC6A2 21284875 258622 Positive_regulation IGF1R TM4SF19 25344917 2206194 Positive_regulation IGF1R TM4SF19 25344917 2206356 Positive_regulation IGF2 ADAMTS1 24962328 2193163 Positive_regulation IGF2 CTGF 23555635 2774667 Positive_regulation IGF2 CTGF 23555635 2774673 Positive_regulation IGF2 EPHB2 20860815 1859253 Positive_regulation IGF2 EPHB2 20860815 1859259 Positive_regulation IGF2 FOXO1 23844554 473456 Positive_regulation IGF2 FOXO1 23844554 473528 Positive_regulation IGF2 FOXO1 23844554 473581 Positive_regulation IGF2 IGFBP1 20924377 436062 Positive_regulation IGF2 IGFBP1 22363400 2598830 Positive_regulation IGF2 IGFBP1 23383064 2747728 Positive_regulation IGF2 IGFBP1 25218581 3176684 Positive_regulation IGF2 IGFBP1 7514606 1435420 Positive_regulation IGF2 TNF 25013674 1143395 Positive_regulation IGF2 TNFSF10 24885194 1874453 Positive_regulation IGF2R RAB31 25472813 1486017 Positive_regulation IGFALS GPNMB 22891158 3131109 Positive_regulation IGFALS PGC 18464922 3072311 Positive_regulation IGFALS PGC 21771318 1892378 Positive_regulation IGFALS TNF 20195368 2441794 Positive_regulation IGFBP1 AHR 24509627 3139731 Positive_regulation IGFBP1 AKT1 23614736 830040 Positive_regulation IGFBP1 AKT2 23614736 830041 Positive_regulation IGFBP1 AKT3 23614736 830042 Positive_regulation IGFBP1 ANGPTL3 24886724 3169973 Positive_regulation IGFBP1 CDK1 21795390 1792887 Positive_regulation IGFBP1 CES2 25397403 3027145 Positive_regulation IGFBP1 COMT 23236253 983736 Positive_regulation IGFBP1 ECM1 7683690 1438808 Positive_regulation IGFBP1 ECM2 7683690 1438809 Positive_regulation IGFBP1 EGF 8595162 445308 Positive_regulation IGFBP1 ERVK-6 10459021 1249133 Positive_regulation IGFBP1 FOXO1 22510882 771772 Positive_regulation IGFBP1 FOXO1 22510882 771780 Positive_regulation IGFBP1 FOXO1 23349855 2743545 Positive_regulation IGFBP1 FOXO1 23614736 830015 Positive_regulation IGFBP1 GH1 24194988 515046 Positive_regulation IGFBP1 HCFC1 21909281 2326258 Positive_regulation IGFBP1 HMGA1 22355763 3130403 Positive_regulation IGFBP1 HMGA1 22355763 3130421 Positive_regulation IGFBP1 HOXA10 21814398 1636509 Positive_regulation IGFBP1 IGF1 12546279 1078026 Positive_regulation IGFBP1 IGF1 22363400 2598837 Positive_regulation IGFBP1 IGF1 24778626 880542 Positive_regulation IGFBP1 IGF1 24899777 175102 Positive_regulation IGFBP1 IGF1 25218581 3176571 Positive_regulation IGFBP1 IGF1 25218581 3176613 Positive_regulation IGFBP1 IGF1 25218581 3176698 Positive_regulation IGFBP1 IGF2 22363400 2598838 Positive_regulation IGFBP1 IGF2 24886724 3169974 Positive_regulation IGFBP1 IGF2 25218581 3176699 Positive_regulation IGFBP1 IGFBP7 23028860 2693464 Positive_regulation IGFBP1 INS 14668045 830409 Positive_regulation IGFBP1 INS 14668047 830497 Positive_regulation IGFBP1 INS 17692117 389815 Positive_regulation IGFBP1 INS 17939336 1711397 Positive_regulation IGFBP1 INS 18234122 3096607 Positive_regulation IGFBP1 INS 20216949 1489869 Positive_regulation IGFBP1 INS 20216949 1489876 Positive_regulation IGFBP1 INS 22493645 1491761 Positive_regulation IGFBP1 INS 22950808 266229 Positive_regulation IGFBP1 INS 24204984 2875083 Positive_regulation IGFBP1 INS 24600406 964408 Positive_regulation IGFBP1 INS 24829560 880574 Positive_regulation IGFBP1 INS 24904693 640843 Positive_regulation IGFBP1 INS 9662244 447292 Positive_regulation IGFBP1 MTOR 15350195 369616 Positive_regulation IGFBP1 MTOR 20216949 1489875 Positive_regulation IGFBP1 PRDX2 24710473 3141444 Positive_regulation IGFBP1 SETD2 18769480 2395898 Positive_regulation IGFBP1 SETD2 21931746 2554311 Positive_regulation IGFBP1 SETD2 24574272 135762 Positive_regulation IGFBP1 SIL1 17042939 319212 Positive_regulation IGFBP3 FOXA1 22879989 2673398 Positive_regulation IGFBP3 FOXA1 22879989 2673399 Positive_regulation IGFBP3 FOXA1 22879989 2673432 Positive_regulation IGFBP3 MMP28 24358328 2899545 Positive_regulation IGFBP3 MMP7 24358328 2899560 Positive_regulation IGFBP3 PLAU 24386080 2902781 Positive_regulation IGFBP3 TNF 14624679 658500 Positive_regulation IGFBP3 TNF 23383064 2747735 Positive_regulation IGFBP3 TNF 23864804 1712141 Positive_regulation IGFBP3 TNF 24964199 2983532 Positive_regulation IGFBP3 TNF 25073020 2993127 Positive_regulation IGFBP5 MAP2K6 24551065 2922942 Positive_regulation IGFBP7 IGFBP1 23028860 2693465 Positive_regulation IGKV1-27 TLR7 21750679 2325136 Positive_regulation IGKV1-27 TNF 17620405 1341827 Positive_regulation IGKV1-27 TNF 17620405 1341832 Positive_regulation IGKV1-27 TNF 17620405 1341844 Positive_regulation IGKV1-27 TNF 19826422 432902 Positive_regulation IGKV1-27 TNF 19826422 432903 Positive_regulation IGKV1-27 TNF 19826422 432922 Positive_regulation IGKV1-27 TNF 19826422 432923 Positive_regulation IGKV1-27 TNF 19826422 432924 Positive_regulation IGKV1-27 TNF 19826422 432927 Positive_regulation IGKV1-27 TNF 19826422 432931 Positive_regulation IGKV1-27 TNF 21151899 2485274 Positive_regulation IGKV1-27 TNF 21151899 2485275 Positive_regulation IGKV1-27 TNF 21151899 2485276 Positive_regulation IGKV1-27 TNF 21242294 1562407 Positive_regulation IGKV1-27 TNF 21488180 3232424 Positive_regulation IGKV1-27 TNF 21754991 2535249 Positive_regulation IGKV1-27 TNF 22507528 1661589 Positive_regulation IGKV1-27 TNF 22507528 1661615 Positive_regulation IGKV1-27 TNF 24479486 1667592 Positive_regulation IGKV1-27 TNF 24489933 2916930 Positive_regulation IGKV1-27 TNF 24595242 1124983 Positive_regulation IGKV1-27 TNF 24741605 1621316 Positive_regulation IGKV1-27 TNF 24971461 2984511 Positive_regulation IHH EPHB2 25003010 3092918 Positive_regulation IKBKB ABCG2 25111504 2996238 Positive_regulation IKBKB EPHB2 22536447 2622501 Positive_regulation IKBKB FOXO1 22649777 939938 Positive_regulation IKBKB MAP2K6 22536447 2622507 Positive_regulation IKBKB TLR7 19734906 1952904 Positive_regulation IKBKB TLR7 19734906 1953035 Positive_regulation IKBKB TLR7 20231379 1557687 Positive_regulation IKBKB TLR7 20231379 1557768 Positive_regulation IKBKB TLR7 21197425 979717 Positive_regulation IKBKB TLR7 21874024 1955691 Positive_regulation IKBKB TLR7 22095690 1033526 Positive_regulation IKBKB TLR7 22984582 2689166 Positive_regulation IKBKB TLR7 23508732 906446 Positive_regulation IKBKB TLR7 23974100 544247 Positive_regulation IKBKB TLR7 24130934 204584 Positive_regulation IKBKB TNF 10359587 1511916 Positive_regulation IKBKB TNF 10359587 1511917 Positive_regulation IKBKB TNF 10359587 1511938 Positive_regulation IKBKB TNF 10359587 1511944 Positive_regulation IKBKB TNF 10748240 1515108 Positive_regulation IKBKB TNF 11238593 1519030 Positive_regulation IKBKB TNF 12426136 791329 Positive_regulation IKBKB TNF 12426136 791330 Positive_regulation IKBKB TNF 16177180 2017711 Positive_regulation IKBKB TNF 17374166 1036263 Positive_regulation IKBKB TNF 17548520 1546324 Positive_regulation IKBKB TNF 17925009 233619 Positive_regulation IKBKB TNF 19343194 2290490 Positive_regulation IKBKB TNF 19568602 3231630 Positive_regulation IKBKB TNF 19640296 325843 Positive_regulation IKBKB TNF 19640296 325846 Positive_regulation IKBKB TNF 20087353 434406 Positive_regulation IKBKB TNF 20087353 434412 Positive_regulation IKBKB TNF 20205746 1656136 Positive_regulation IKBKB TNF 20351780 2444542 Positive_regulation IKBKB TNF 20351780 2444562 Positive_regulation IKBKB TNF 20351780 2444571 Positive_regulation IKBKB TNF 20351780 2444603 Positive_regulation IKBKB TNF 20416113 402579 Positive_regulation IKBKB TNF 20543835 1964781 Positive_regulation IKBKB TNF 20671994 506632 Positive_regulation IKBKB TNF 20695076 1142941 Positive_regulation IKBKB TNF 21119000 1783914 Positive_regulation IKBKB TNF 21119000 1783947 Positive_regulation IKBKB TNF 21119000 1783970 Positive_regulation IKBKB TNF 21342546 238015 Positive_regulation IKBKB TNF 21342546 238031 Positive_regulation IKBKB TNF 21342546 238043 Positive_regulation IKBKB TNF 21399639 1955167 Positive_regulation IKBKB TNF 21699726 1658634 Positive_regulation IKBKB TNF 21729324 238218 Positive_regulation IKBKB TNF 22069560 3181839 Positive_regulation IKBKB TNF 22267916 983518 Positive_regulation IKBKB TNF 22351606 778142 Positive_regulation IKBKB TNF 22768286 2660403 Positive_regulation IKBKB TNF 22768286 2660420 Positive_regulation IKBKB TNF 22848449 2669106 Positive_regulation IKBKB TNF 22991685 1082675 Positive_regulation IKBKB TNF 23042150 1957929 Positive_regulation IKBKB TNF 23071583 2702989 Positive_regulation IKBKB TNF 23071583 2703088 Positive_regulation IKBKB TNF 23071583 2703089 Positive_regulation IKBKB TNF 23071583 2703134 Positive_regulation IKBKB TNF 23104095 1958288 Positive_regulation IKBKB TNF 23284617 2730270 Positive_regulation IKBKB TNF 23284617 2730274 Positive_regulation IKBKB TNF 23284617 2730277 Positive_regulation IKBKB TNF 23419260 1637676 Positive_regulation IKBKB TNF 23424624 2755007 Positive_regulation IKBKB TNF 23437404 2756813 Positive_regulation IKBKB TNF 23437404 2756917 Positive_regulation IKBKB TNF 23603982 17460 Positive_regulation IKBKB TNF 23603982 17477 Positive_regulation IKBKB TNF 23690855 819196 Positive_regulation IKBKB TNF 23770847 2152634 Positive_regulation IKBKB TNF 24260470 2884427 Positive_regulation IKBKB TNF 24386331 2903502 Positive_regulation IKBKB TNF 24386331 2903540 Positive_regulation IKBKB TNF 24386633 186129 Positive_regulation IKBKB TNF 24487321 1959832 Positive_regulation IKBKB TNF 24487321 1959855 Positive_regulation IKBKB TNF 24487321 1959859 Positive_regulation IKBKB TNF 24516376 2299609 Positive_regulation IKBKB TNF 24911653 152855 Positive_regulation IKBKB TNF 25134539 1883932 Positive_regulation IKBKB TNF 25152696 1628009 Positive_regulation IKBKB TNF 25229347 3007955 Positive_regulation IKBKB TNF 25427002 3030382 Positive_regulation IKBKB TNF 25530974 1496790 Positive_regulation IKBKB TNF 25553117 3177738 Positive_regulation IKBKB TNFSF10 22048166 553356 Positive_regulation IKBKB TNFSF10 22672528 482521 Positive_regulation IKBKG ABCG2 25111504 2996239 Positive_regulation IKBKG EPHB2 22536447 2622509 Positive_regulation IKBKG FOXO1 22649777 939942 Positive_regulation IKBKG MAP2K6 22536447 2622515 Positive_regulation IKBKG TLR7 19734906 1952916 Positive_regulation IKBKG TLR7 19734906 1953051 Positive_regulation IKBKG TLR7 20231379 1557700 Positive_regulation IKBKG TLR7 20231379 1557778 Positive_regulation IKBKG TLR7 21197425 979728 Positive_regulation IKBKG TLR7 21874024 1955701 Positive_regulation IKBKG TLR7 22095690 1033536 Positive_regulation IKBKG TLR7 22984582 2689176 Positive_regulation IKBKG TLR7 23508732 906456 Positive_regulation IKBKG TLR7 23974100 544257 Positive_regulation IKBKG TLR7 24130934 204594 Positive_regulation IKBKG TNF 10359587 1511920 Positive_regulation IKBKG TNF 10359587 1511921 Positive_regulation IKBKG TNF 10359587 1511940 Positive_regulation IKBKG TNF 10359587 1511946 Positive_regulation IKBKG TNF 10748240 1515111 Positive_regulation IKBKG TNF 11238593 1519031 Positive_regulation IKBKG TNF 12426136 791358 Positive_regulation IKBKG TNF 12426136 791359 Positive_regulation IKBKG TNF 17374166 1036264 Positive_regulation IKBKG TNF 17548520 1546325 Positive_regulation IKBKG TNF 17925009 233620 Positive_regulation IKBKG TNF 19343194 2290491 Positive_regulation IKBKG TNF 19568602 3231631 Positive_regulation IKBKG TNF 20087353 434407 Positive_regulation IKBKG TNF 20087353 434413 Positive_regulation IKBKG TNF 20205746 1656137 Positive_regulation IKBKG TNF 20351780 2444545 Positive_regulation IKBKG TNF 20351780 2444563 Positive_regulation IKBKG TNF 20351780 2444572 Positive_regulation IKBKG TNF 20351780 2444604 Positive_regulation IKBKG TNF 20416113 402584 Positive_regulation IKBKG TNF 20484576 1776875 Positive_regulation IKBKG TNF 20543835 1964782 Positive_regulation IKBKG TNF 20671994 506633 Positive_regulation IKBKG TNF 20695076 1142952 Positive_regulation IKBKG TNF 21119000 1783917 Positive_regulation IKBKG TNF 21119000 1783949 Positive_regulation IKBKG TNF 21119000 1783974 Positive_regulation IKBKG TNF 21342546 238016 Positive_regulation IKBKG TNF 21342546 238032 Positive_regulation IKBKG TNF 21342546 238044 Positive_regulation IKBKG TNF 21399639 1955168 Positive_regulation IKBKG TNF 21699726 1658635 Positive_regulation IKBKG TNF 21729324 238219 Positive_regulation IKBKG TNF 22069560 3181841 Positive_regulation IKBKG TNF 22267916 983519 Positive_regulation IKBKG TNF 22351606 778143 Positive_regulation IKBKG TNF 22768286 2660404 Positive_regulation IKBKG TNF 22768286 2660421 Positive_regulation IKBKG TNF 22848449 2669107 Positive_regulation IKBKG TNF 22991685 1082676 Positive_regulation IKBKG TNF 23042150 1957930 Positive_regulation IKBKG TNF 23071583 2702990 Positive_regulation IKBKG TNF 23071583 2703090 Positive_regulation IKBKG TNF 23071583 2703091 Positive_regulation IKBKG TNF 23071583 2703135 Positive_regulation IKBKG TNF 23104095 1958273 Positive_regulation IKBKG TNF 23104095 1958290 Positive_regulation IKBKG TNF 23284617 2730271 Positive_regulation IKBKG TNF 23284617 2730275 Positive_regulation IKBKG TNF 23284617 2730278 Positive_regulation IKBKG TNF 23419260 1637678 Positive_regulation IKBKG TNF 23424624 2755008 Positive_regulation IKBKG TNF 23437404 2756817 Positive_regulation IKBKG TNF 23437404 2756918 Positive_regulation IKBKG TNF 23603982 17461 Positive_regulation IKBKG TNF 23603982 17478 Positive_regulation IKBKG TNF 23690855 819197 Positive_regulation IKBKG TNF 23770847 2152637 Positive_regulation IKBKG TNF 24260470 2884428 Positive_regulation IKBKG TNF 24386331 2903503 Positive_regulation IKBKG TNF 24386331 2903541 Positive_regulation IKBKG TNF 24386633 186130 Positive_regulation IKBKG TNF 24446482 1415322 Positive_regulation IKBKG TNF 24487321 1959833 Positive_regulation IKBKG TNF 24487321 1959856 Positive_regulation IKBKG TNF 24487321 1959861 Positive_regulation IKBKG TNF 24516376 2299610 Positive_regulation IKBKG TNF 24911653 152857 Positive_regulation IKBKG TNF 25134539 1883933 Positive_regulation IKBKG TNF 25134539 1883936 Positive_regulation IKBKG TNF 25152696 1628010 Positive_regulation IKBKG TNF 25229347 3007957 Positive_regulation IKBKG TNF 25427002 3030383 Positive_regulation IKBKG TNF 25530974 1496791 Positive_regulation IKBKG TNF 25553117 3177739 Positive_regulation IKBKG TNFSF10 22048166 553357 Positive_regulation IKBKG TNFSF10 22672528 482522 Positive_regulation IL10 CD14 17242961 810080 Positive_regulation IL10 CD14 17242961 810099 Positive_regulation IL10 CD14 20946675 1723270 Positive_regulation IL10 CD14 20946675 1723271 Positive_regulation IL10 CD14 22442690 2613030 Positive_regulation IL10 CD14 24165011 3123879 Positive_regulation IL10 CD14 25025695 2989330 Positive_regulation IL10 CEACAM6 23554642 1225816 Positive_regulation IL10 CEACAM6 23554642 1225819 Positive_regulation IL10 CHI3L1 21714862 123067 Positive_regulation IL10 CST6 22072824 1713239 Positive_regulation IL10 CST6 25275395 2373004 Positive_regulation IL10 EPHB2 15841257 810581 Positive_regulation IL10 EPHB2 17664287 1546713 Positive_regulation IL10 EPHB2 18648505 2393014 Positive_regulation IL10 EPHB2 19667062 1555678 Positive_regulation IL10 EPHB2 19667062 1555679 Positive_regulation IL10 EPHB2 20008527 1556953 Positive_regulation IL10 EPHB2 22566973 900643 Positive_regulation IL10 EPHB2 22969768 904220 Positive_regulation IL10 EPHB2 22969768 904247 Positive_regulation IL10 EPHB2 23667643 2790921 Positive_regulation IL10 EPHB2 23853721 1689952 Positive_regulation IL10 EPHB2 23901045 1065492 Positive_regulation IL10 EPHB2 24191131 1754978 Positive_regulation IL10 EPHB2 24191131 1754998 Positive_regulation IL10 EPHB2 24191131 1755002 Positive_regulation IL10 EPHB2 24480801 840374 Positive_regulation IL10 EPHB2 24855454 1627913 Positive_regulation IL10 FAS 9730890 1603536 Positive_regulation IL10 IL1B 20498845 2451119 Positive_regulation IL10 IL1B PMC137244 660840 Positive_regulation IL10 JAG1 20856680 2474680 Positive_regulation IL10 JAG1 23335969 2741147 Positive_regulation IL10 JAG1 7905018 1592873 Positive_regulation IL10 LBP 22442690 2613031 Positive_regulation IL10 LBP 25025695 2989331 Positive_regulation IL10 MAP2K6 19534815 1696305 Positive_regulation IL10 MAP2K6 19646904 1040086 Positive_regulation IL10 MAP2K6 23901045 1065498 Positive_regulation IL10 MAP2K6 24855454 1627907 Positive_regulation IL10 MIP 20544034 2452626 Positive_regulation IL10 MUC16 21331365 632328 Positive_regulation IL10 MUC16 21331365 632367 Positive_regulation IL10 NGFR 22880054 2673970 Positive_regulation IL10 NGFR 22880054 2674014 Positive_regulation IL10 PTGER2 25098409 2995465 Positive_regulation IL10 RNF150 23847409 649686 Positive_regulation IL10 S100A7 22230654 3112895 Positive_regulation IL10 SRGN 16551363 3107021 Positive_regulation IL10 SRGN 16551363 3107022 Positive_regulation IL10 SRGN 16551363 3107024 Positive_regulation IL10 STAT4 19646904 1040094 Positive_regulation IL10 STAT4 19646904 1040113 Positive_regulation IL10 STAT4 19646904 1040126 Positive_regulation IL10 STAT4 22566914 900001 Positive_regulation IL10 STAT4 22969768 904238 Positive_regulation IL10 STK39 23800014 1232282 Positive_regulation IL10 TLR7 11686880 3103156 Positive_regulation IL10 TLR7 12391011 1525077 Positive_regulation IL10 TLR7 17485512 1545788 Positive_regulation IL10 TLR7 17485512 1545921 Positive_regulation IL10 TLR7 17893200 1547131 Positive_regulation IL10 TLR7 17918201 807203 Positive_regulation IL10 TLR7 18195076 1548711 Positive_regulation IL10 TLR7 18322684 487990 Positive_regulation IL10 TLR7 19204112 1554042 Positive_regulation IL10 TLR7 19519922 113484 Positive_regulation IL10 TLR7 19667062 1555594 Positive_regulation IL10 TLR7 19667062 1555700 Positive_regulation IL10 TLR7 20625435 2455127 Positive_regulation IL10 TLR7 20625435 2455157 Positive_regulation IL10 TLR7 20672047 1747588 Positive_regulation IL10 TLR7 20821041 1491412 Positive_regulation IL10 TLR7 20837696 1560143 Positive_regulation IL10 TLR7 20862346 979375 Positive_regulation IL10 TLR7 21152080 2486080 Positive_regulation IL10 TLR7 21152080 2486087 Positive_regulation IL10 TLR7 21188217 1081622 Positive_regulation IL10 TLR7 21533209 2515514 Positive_regulation IL10 TLR7 22053215 2568117 Positive_regulation IL10 TLR7 22197976 1956470 Positive_regulation IL10 TLR7 22526791 94528 Positive_regulation IL10 TLR7 22556042 1050661 Positive_regulation IL10 TLR7 22556042 1050685 Positive_regulation IL10 TLR7 22556042 1050717 Positive_regulation IL10 TLR7 22563430 2626468 Positive_regulation IL10 TLR7 22563430 2626469 Positive_regulation IL10 TLR7 22563430 2626483 Positive_regulation IL10 TLR7 22563430 2626493 Positive_regulation IL10 TLR7 22649499 2646628 Positive_regulation IL10 TLR7 22737608 2161024 Positive_regulation IL10 TLR7 22745643 1713993 Positive_regulation IL10 TLR7 22768144 2659893 Positive_regulation IL10 TLR7 22815909 2666677 Positive_regulation IL10 TLR7 22880012 2673566 Positive_regulation IL10 TLR7 22911108 3058837 Positive_regulation IL10 TLR7 22927956 2681209 Positive_regulation IL10 TLR7 23028609 2691906 Positive_regulation IL10 TLR7 23194300 356090 Positive_regulation IL10 TLR7 23209848 2371635 Positive_regulation IL10 TLR7 23408948 2752966 Positive_regulation IL10 TLR7 23724100 2799001 Positive_regulation IL10 TLR7 23826189 2810733 Positive_regulation IL10 TLR7 23826189 2810739 Positive_regulation IL10 TLR7 24191131 1754988 Positive_regulation IL10 TLR7 24191131 1754997 Positive_regulation IL10 TLR7 24330199 596355 Positive_regulation IL10 TLR7 24330710 538596 Positive_regulation IL10 TLR7 25010048 2987723 Positive_regulation IL10 TLR7 25071732 927098 Positive_regulation IL10 TLR7 25071732 927129 Positive_regulation IL10 TLR7 25083184 1078068 Positive_regulation IL10 TLR7 25093709 34304 Positive_regulation IL10 TLR7 25112836 1619083 Positive_regulation IL10 TLR7 25157202 1761778 Positive_regulation IL10 TLR7 25309919 201184 Positive_regulation IL10 TLR7 25368611 914932 Positive_regulation IL10 TLR7 25386178 915051 Positive_regulation IL10 TLR7 25392121 1946634 Positive_regulation IL10 TLR7 25538892 949188 Positive_regulation IL10 TLR7 25566514 865348 Positive_regulation IL10 TLR7 PMC3242235 1702561 Positive_regulation IL10 TNF 10408703 414816 Positive_regulation IL10 TNF 10408703 414817 Positive_regulation IL10 TNF 10408703 414818 Positive_regulation IL10 TNF 10408703 414819 Positive_regulation IL10 TNF 10408703 414853 Positive_regulation IL10 TNF 11094448 98184 Positive_regulation IL10 TNF 11577995 1737880 Positive_regulation IL10 TNF 11781361 1522112 Positive_regulation IL10 TNF 11879539 98597 Positive_regulation IL10 TNF 12002297 1708901 Positive_regulation IL10 TNF 12110137 99167 Positive_regulation IL10 TNF 12575899 1843403 Positive_regulation IL10 TNF 1311016 1528329 Positive_regulation IL10 TNF 15059265 100922 Positive_regulation IL10 TNF 15770065 1740015 Positive_regulation IL10 TNF 1586593 426049 Positive_regulation IL10 TNF 1643416 702473 Positive_regulation IL10 TNF 16859503 106276 Positive_regulation IL10 TNF 1692079 1542184 Positive_regulation IL10 TNF 1717633 1543721 Positive_regulation IL10 TNF 18475440 1743768 Positive_regulation IL10 TNF 1911209 431571 Positive_regulation IL10 TNF 19451266 1554828 Positive_regulation IL10 TNF 19701461 2424383 Positive_regulation IL10 TNF 19742190 1048178 Positive_regulation IL10 TNF 19936089 981549 Positive_regulation IL10 TNF 20051129 3110167 Positive_regulation IL10 TNF 2007858 1557298 Positive_regulation IL10 TNF 20194223 3126168 Positive_regulation IL10 TNF 2022925 1557577 Positive_regulation IL10 TNF 2022925 1557605 Positive_regulation IL10 TNF 20370890 1723010 Positive_regulation IL10 TNF 2039696 434759 Positive_regulation IL10 TNF 20544034 2452623 Positive_regulation IL10 TNF 20798882 1670089 Positive_regulation IL10 TNF 20808962 2473136 Positive_regulation IL10 TNF 21170379 2487261 Positive_regulation IL10 TNF 21245929 2492849 Positive_regulation IL10 TNF 21291387 668410 Positive_regulation IL10 TNF 21314968 3209858 Positive_regulation IL10 TNF 21410959 121893 Positive_regulation IL10 TNF 21738265 1713139 Positive_regulation IL10 TNF 21829352 3052668 Positive_regulation IL10 TNF 2183871 437506 Positive_regulation IL10 TNF 2183871 437571 Positive_regulation IL10 TNF 2183871 437572 Positive_regulation IL10 TNF 2183871 437615 Positive_regulation IL10 TNF 21904602 2550402 Positive_regulation IL10 TNF 22028806 2564405 Positive_regulation IL10 TNF 22056617 13641 Positive_regulation IL10 TNF 22095690 1033506 Positive_regulation IL10 TNF 22110376 1058210 Positive_regulation IL10 TNF 22125677 2115084 Positive_regulation IL10 TNF 22272381 1082511 Positive_regulation IL10 TNF 22359634 2598640 Positive_regulation IL10 TNF 22363214 3055731 Positive_regulation IL10 TNF 22457616 3055877 Positive_regulation IL10 TNF 22518279 1079959 Positive_regulation IL10 TNF 22530124 2009502 Positive_regulation IL10 TNF 22545014 3152563 Positive_regulation IL10 TNF 22547990 3152631 Positive_regulation IL10 TNF 22556042 1050694 Positive_regulation IL10 TNF 2258696 1568193 Positive_regulation IL10 TNF 22615502 1044049 Positive_regulation IL10 TNF 22844426 2668146 Positive_regulation IL10 TNF 22879986 2673391 Positive_regulation IL10 TNF 22880012 2673565 Positive_regulation IL10 TNF 22909062 3214973 Positive_regulation IL10 TNF 22916219 2680212 Positive_regulation IL10 TNF 23008734 636968 Positive_regulation IL10 TNF 23029434 2697377 Positive_regulation IL10 TNF 23082146 2705290 Positive_regulation IL10 TNF 23173923 381123 Positive_regulation IL10 TNF 23227067 3204540 Positive_regulation IL10 TNF 23316193 905649 Positive_regulation IL10 TNF 23509800 180373 Positive_regulation IL10 TNF 23509825 180601 Positive_regulation IL10 TNF 23555865 2775701 Positive_regulation IL10 TNF 23680127 3204398 Positive_regulation IL10 TNF 2373990 1572268 Positive_regulation IL10 TNF 23798880 2248511 Positive_regulation IL10 TNF 23861894 2820587 Positive_regulation IL10 TNF 23869227 2821180 Positive_regulation IL10 TNF 23902576 308347 Positive_regulation IL10 TNF 23908975 649294 Positive_regulation IL10 TNF 24015193 2842203 Positive_regulation IL10 TNF 2406363 1573699 Positive_regulation IL10 TNF 24130911 2372250 Positive_regulation IL10 TNF 24187561 638999 Positive_regulation IL10 TNF 24212943 499210 Positive_regulation IL10 TNF 24492460 1940528 Positive_regulation IL10 TNF 24492460 1940530 Positive_regulation IL10 TNF 24651069 2372473 Positive_regulation IL10 TNF 24655411 19995 Positive_regulation IL10 TNF 24722226 3066654 Positive_regulation IL10 TNF 24804272 1621486 Positive_regulation IL10 TNF 24911280 2977600 Positive_regulation IL10 TNF 24943108 356642 Positive_regulation IL10 TNF 24971344 193370 Positive_regulation IL10 TNF 2499653 1576988 Positive_regulation IL10 TNF 25085377 88955 Positive_regulation IL10 TNF 25329163 3015914 Positive_regulation IL10 TNF 25566088 967314 Positive_regulation IL10 TNF 25566439 1498414 Positive_regulation IL10 TNF 25629008 865421 Positive_regulation IL10 TNF 2642531 1577565 Positive_regulation IL10 TNF 2659724 1577654 Positive_regulation IL10 TNF 2769183 1577879 Positive_regulation IL10 TNF 2785398 442921 Positive_regulation IL10 TNF 2803928 443142 Positive_regulation IL10 TNF 2833558 1578533 Positive_regulation IL10 TNF 3049617 1425468 Positive_regulation IL10 TNF 3049617 1425469 Positive_regulation IL10 TNF 3049617 1425576 Positive_regulation IL10 TNF 3049617 1425577 Positive_regulation IL10 TNF 3110354 1580052 Positive_regulation IL10 TNF 3137305 1580365 Positive_regulation IL10 TNF 3143799 1580420 Positive_regulation IL10 TNF 3290384 1580786 Positive_regulation IL10 TNF 3309124 1580905 Positive_regulation IL10 TNF 3309124 1580959 Positive_regulation IL10 TNF 3316469 1581019 Positive_regulation IL10 TNF 3411293 1581185 Positive_regulation IL10 TNF 3435706 443500 Positive_regulation IL10 TNF 3491174 1583091 Positive_regulation IL10 TNF 3494807 1583253 Positive_regulation IL10 TNF 3494807 1583254 Positive_regulation IL10 TNF 3494807 1583329 Positive_regulation IL10 TNF 3572302 1583468 Positive_regulation IL10 TNF 3598461 1583526 Positive_regulation IL10 TNF 3598461 1583561 Positive_regulation IL10 TNF 3819645 1583703 Positive_regulation IL10 TNF 7964475 1593460 Positive_regulation IL10 TNF 7964475 1593461 Positive_regulation IL10 TNF 7964475 1593462 Positive_regulation IL10 TNF 7964475 1593463 Positive_regulation IL10 TNF 7964475 1593468 Positive_regulation IL10 TNF 7964475 1593471 Positive_regulation IL10 TNF 7964475 1593472 Positive_regulation IL10 TNF 8163935 1594284 Positive_regulation IL10 TNF 8426121 1595195 Positive_regulation IL10 TNF 8478614 1595545 Positive_regulation IL10 TNF PMC2188223 1605394 Positive_regulation IL10RA TNF 23569462 1240030 Positive_regulation IL10RB TNF 23569462 1240031 Positive_regulation IL11 CD14 25025695 2989332 Positive_regulation IL11 EPHB2 25340554 3018710 Positive_regulation IL11 LBP 25025695 2989333 Positive_regulation IL11 TLR7 11686880 3103166 Positive_regulation IL11 TNF 11094428 98168 Positive_regulation IL11 TNF 11132773 1737248 Positive_regulation IL11 TNF 1311016 1528330 Positive_regulation IL11 TNF 1586593 426050 Positive_regulation IL11 TNF 1643416 702474 Positive_regulation IL11 TNF 1692079 1542185 Positive_regulation IL11 TNF 1717633 1543722 Positive_regulation IL11 TNF 18475440 1743769 Positive_regulation IL11 TNF 1911209 431572 Positive_regulation IL11 TNF 19742190 1048179 Positive_regulation IL11 TNF 19936089 981551 Positive_regulation IL11 TNF 2007858 1557299 Positive_regulation IL11 TNF 2022925 1557578 Positive_regulation IL11 TNF 2022925 1557606 Positive_regulation IL11 TNF 2039696 434760 Positive_regulation IL11 TNF 20808962 2473137 Positive_regulation IL11 TNF 21829352 3052700 Positive_regulation IL11 TNF 2183871 437507 Positive_regulation IL11 TNF 2183871 437573 Positive_regulation IL11 TNF 2183871 437574 Positive_regulation IL11 TNF 2183871 437616 Positive_regulation IL11 TNF 2258696 1568194 Positive_regulation IL11 TNF 2373990 1572269 Positive_regulation IL11 TNF 2406363 1573700 Positive_regulation IL11 TNF 2499653 1576989 Positive_regulation IL11 TNF 2642531 1577566 Positive_regulation IL11 TNF 2659724 1577655 Positive_regulation IL11 TNF 2769183 1577880 Positive_regulation IL11 TNF 2785398 442922 Positive_regulation IL11 TNF 2803928 443143 Positive_regulation IL11 TNF 2833558 1578534 Positive_regulation IL11 TNF 3049617 1425470 Positive_regulation IL11 TNF 3049617 1425471 Positive_regulation IL11 TNF 3049617 1425578 Positive_regulation IL11 TNF 3049617 1425579 Positive_regulation IL11 TNF 3110354 1580053 Positive_regulation IL11 TNF 3137305 1580366 Positive_regulation IL11 TNF 3143799 1580421 Positive_regulation IL11 TNF 3290384 1580787 Positive_regulation IL11 TNF 3309124 1580906 Positive_regulation IL11 TNF 3309124 1580960 Positive_regulation IL11 TNF 3316469 1581020 Positive_regulation IL11 TNF 3411293 1581186 Positive_regulation IL11 TNF 3435706 443501 Positive_regulation IL11 TNF 3491174 1583092 Positive_regulation IL11 TNF 3494807 1583255 Positive_regulation IL11 TNF 3494807 1583256 Positive_regulation IL11 TNF 3494807 1583330 Positive_regulation IL11 TNF 3572302 1583469 Positive_regulation IL11 TNF 3598461 1583527 Positive_regulation IL11 TNF 3598461 1583562 Positive_regulation IL11 TNF 3819645 1583704 Positive_regulation IL11 TNF 8426121 1595196 Positive_regulation IL11 TNF 8478614 1595546 Positive_regulation IL11 TNF 8676079 1597970 Positive_regulation IL11 TNF PMC2188223 1605395 Positive_regulation IL12A ALOX5 12417634 1525197 Positive_regulation IL12A ALOX5 23613965 2782920 Positive_regulation IL12A CCL17 22737174 636387 Positive_regulation IL12A CD14 15841259 810592 Positive_regulation IL12A CD14 23223197 3221947 Positive_regulation IL12A EPHB2 15841257 810584 Positive_regulation IL12A EPHB2 18648505 2393171 Positive_regulation IL12A EPHB2 18648505 2393251 Positive_regulation IL12A EPHB2 19667062 1555602 Positive_regulation IL12A EPHB2 19667062 1555681 Positive_regulation IL12A EPHB2 19667062 1555728 Positive_regulation IL12A EPHB2 22537317 355842 Positive_regulation IL12A EPHB2 22537317 355860 Positive_regulation IL12A EPHB2 23853721 1689953 Positive_regulation IL12A ETV7 25126585 1622929 Positive_regulation IL12A F2R 24015257 2842548 Positive_regulation IL12A FAS 23762085 637558 Positive_regulation IL12A FAS 24514955 488381 Positive_regulation IL12A FOXO1 24864265 191800 Positive_regulation IL12A IL1B 23209897 97730 Positive_regulation IL12A MUC16 25120285 1760429 Positive_regulation IL12A NES 25133189 196812 Positive_regulation IL12A RAB31 24165808 809029 Positive_regulation IL12A RORC 24453425 1756974 Positive_regulation IL12A STAT4 10587348 1513265 Positive_regulation IL12A STAT4 11034602 1517714 Positive_regulation IL12A STAT4 11405550 1737798 Positive_regulation IL12A STAT4 15526047 2368211 Positive_regulation IL12A STAT4 15699073 1534514 Positive_regulation IL12A STAT4 16520391 1539675 Positive_regulation IL12A STAT4 16717115 1540377 Positive_regulation IL12A STAT4 16717115 1540378 Positive_regulation IL12A STAT4 18803832 111218 Positive_regulation IL12A STAT4 20018088 395455 Positive_regulation IL12A STAT4 20479986 1090096 Positive_regulation IL12A STAT4 20956546 1561002 Positive_regulation IL12A STAT4 21603246 648197 Positive_regulation IL12A STAT4 21635716 122596 Positive_regulation IL12A STAT4 21695280 2324813 Positive_regulation IL12A STAT4 21884628 1490574 Positive_regulation IL12A STAT4 22110388 1058560 Positive_regulation IL12A STAT4 22493582 956819 Positive_regulation IL12A STAT4 22493582 956909 Positive_regulation IL12A STAT4 22729903 1832226 Positive_regulation IL12A STAT4 23285134 2732624 Positive_regulation IL12A STAT4 23555662 2774770 Positive_regulation IL12A STAT4 24058746 1704740 Positive_regulation IL12A STAT4 24058793 1705875 Positive_regulation IL12A STAT4 24058793 1705926 Positive_regulation IL12A STAT4 24058795 1705941 Positive_regulation IL12A STAT4 24058795 1705957 Positive_regulation IL12A STAT4 24097067 1951590 Positive_regulation IL12A STAT4 24188121 1728464 Positive_regulation IL12A STAT4 24363024 488374 Positive_regulation IL12A STAT4 24416649 1708326 Positive_regulation IL12A STAT4 24455433 3151156 Positive_regulation IL12A STAT4 25259790 3010645 Positive_regulation IL12A STAT4 7722452 1591967 Positive_regulation IL12A STAT4 7722452 1591979 Positive_regulation IL12A STAT4 8666939 1597347 Positive_regulation IL12A STAT4 9120388 1600991 Positive_regulation IL12A STAT4 9120388 1600992 Positive_regulation IL12A STAT4 9120388 1601023 Positive_regulation IL12A STAT4 9120388 1601027 Positive_regulation IL12A STAT4 9743537 1603894 Positive_regulation IL12A TLR7 12045249 1523543 Positive_regulation IL12A TLR7 12515808 1525665 Positive_regulation IL12A TLR7 12719479 1526956 Positive_regulation IL12A TLR7 15492123 1533655 Positive_regulation IL12A TLR7 15851485 1535732 Positive_regulation IL12A TLR7 15851485 1535733 Positive_regulation IL12A TLR7 15851485 1535734 Positive_regulation IL12A TLR7 15851485 1535735 Positive_regulation IL12A TLR7 15851485 1535941 Positive_regulation IL12A TLR7 16330816 1538756 Positive_regulation IL12A TLR7 16365150 1539029 Positive_regulation IL12A TLR7 16542467 105089 Positive_regulation IL12A TLR7 17371930 1544843 Positive_regulation IL12A TLR7 17371930 1544844 Positive_regulation IL12A TLR7 17371930 1544934 Positive_regulation IL12A TLR7 17371930 1544964 Positive_regulation IL12A TLR7 17371930 1544989 Positive_regulation IL12A TLR7 17485511 1545624 Positive_regulation IL12A TLR7 17485512 1545864 Positive_regulation IL12A TLR7 18086320 109596 Positive_regulation IL12A TLR7 18195076 1548723 Positive_regulation IL12A TLR7 18322684 487887 Positive_regulation IL12A TLR7 18322684 487970 Positive_regulation IL12A TLR7 18411340 1550349 Positive_regulation IL12A TLR7 18442421 1043630 Positive_regulation IL12A TLR7 18461564 807265 Positive_regulation IL12A TLR7 18461564 807355 Positive_regulation IL12A TLR7 18461564 807438 Positive_regulation IL12A TLR7 18461564 807478 Positive_regulation IL12A TLR7 18490488 1551188 Positive_regulation IL12A TLR7 18584038 3074217 Positive_regulation IL12A TLR7 19077314 1727834 Positive_regulation IL12A TLR7 19108028 3231544 Positive_regulation IL12A TLR7 19325820 1087885 Positive_regulation IL12A TLR7 19430534 2416172 Positive_regulation IL12A TLR7 19430534 2416173 Positive_regulation IL12A TLR7 19430534 2416252 Positive_regulation IL12A TLR7 19430534 2416301 Positive_regulation IL12A TLR7 19609356 3044595 Positive_regulation IL12A TLR7 19667062 1555718 Positive_regulation IL12A TLR7 19667062 1555719 Positive_regulation IL12A TLR7 19737867 1556195 Positive_regulation IL12A TLR7 19766674 1042555 Positive_regulation IL12A TLR7 19881508 1953383 Positive_regulation IL12A TLR7 20193084 1727927 Positive_regulation IL12A TLR7 20204070 1213918 Positive_regulation IL12A TLR7 20379390 1214521 Positive_regulation IL12A TLR7 20479986 1090137 Positive_regulation IL12A TLR7 20929569 403166 Positive_regulation IL12A TLR7 20934454 1042636 Positive_regulation IL12A TLR7 21060840 2480840 Positive_regulation IL12A TLR7 21060840 2480907 Positive_regulation IL12A TLR7 21060840 2480971 Positive_regulation IL12A TLR7 21124820 3050093 Positive_regulation IL12A TLR7 21152080 2486107 Positive_regulation IL12A TLR7 21314903 3209789 Positive_regulation IL12A TLR7 21494377 1038049 Positive_regulation IL12A TLR7 21499439 178160 Positive_regulation IL12A TLR7 21533209 2515545 Positive_regulation IL12A TLR7 21994612 3218933 Positive_regulation IL12A TLR7 22110383 1058512 Positive_regulation IL12A TLR7 22116297 1050372 Positive_regulation IL12A TLR7 22243920 357085 Positive_regulation IL12A TLR7 22427987 2610882 Positive_regulation IL12A TLR7 22513098 125435 Positive_regulation IL12A TLR7 22523644 1680593 Positive_regulation IL12A TLR7 22566937 900265 Positive_regulation IL12A TLR7 22570785 1688522 Positive_regulation IL12A TLR7 22661952 957523 Positive_regulation IL12A TLR7 22815909 2666775 Positive_regulation IL12A TLR7 22863292 366851 Positive_regulation IL12A TLR7 22927956 2681210 Positive_regulation IL12A TLR7 23061052 863704 Positive_regulation IL12A TLR7 23071254 1569658 Positive_regulation IL12A TLR7 23133361 2297608 Positive_regulation IL12A TLR7 23162549 904949 Positive_regulation IL12A TLR7 23162550 905039 Positive_regulation IL12A TLR7 23189270 863860 Positive_regulation IL12A TLR7 23197922 88261 Positive_regulation IL12A TLR7 23209848 2371645 Positive_regulation IL12A TLR7 23221473 3217389 Positive_regulation IL12A TLR7 23299509 1022893 Positive_regulation IL12A TLR7 23396449 2085557 Positive_regulation IL12A TLR7 23408948 2752976 Positive_regulation IL12A TLR7 23421931 590850 Positive_regulation IL12A TLR7 23421931 590920 Positive_regulation IL12A TLR7 23429360 838519 Positive_regulation IL12A TLR7 23448601 535777 Positive_regulation IL12A TLR7 23557436 359069 Positive_regulation IL12A TLR7 23675302 3061424 Positive_regulation IL12A TLR7 23735002 2231715 Positive_regulation IL12A TLR7 23755218 2801993 Positive_regulation IL12A TLR7 23755218 2801994 Positive_regulation IL12A TLR7 23758787 1649602 Positive_regulation IL12A TLR7 23762309 2802944 Positive_regulation IL12A TLR7 23787171 1666842 Positive_regulation IL12A TLR7 23800014 1232235 Positive_regulation IL12A TLR7 23940256 1573346 Positive_regulation IL12A TLR7 23940791 2832481 Positive_regulation IL12A TLR7 23951210 2833756 Positive_regulation IL12A TLR7 23967307 2835782 Positive_regulation IL12A TLR7 23967307 2836099 Positive_regulation IL12A TLR7 23967307 2836100 Positive_regulation IL12A TLR7 23967307 2836190 Positive_regulation IL12A TLR7 24058791 1705806 Positive_regulation IL12A TLR7 24098413 2856207 Positive_regulation IL12A TLR7 24130498 3064588 Positive_regulation IL12A TLR7 24155889 2871038 Positive_regulation IL12A TLR7 24178712 3223563 Positive_regulation IL12A TLR7 24224170 184912 Positive_regulation IL12A TLR7 24282405 909971 Positive_regulation IL12A TLR7 24379524 1756110 Positive_regulation IL12A TLR7 24379524 1756144 Positive_regulation IL12A TLR7 24489947 2917034 Positive_regulation IL12A TLR7 24523723 911025 Positive_regulation IL12A TLR7 24708419 1043499 Positive_regulation IL12A TLR7 24802102 2961887 Positive_regulation IL12A TLR7 24842926 1049990 Positive_regulation IL12A TLR7 24884741 1701751 Positive_regulation IL12A TLR7 24910635 913036 Positive_regulation IL12A TLR7 25071732 926957 Positive_regulation IL12A TLR7 25133189 196835 Positive_regulation IL12A TLR7 25157202 1761779 Positive_regulation IL12A TLR7 25392121 1946664 Positive_regulation IL12A TLR7 25429207 3216518 Positive_regulation IL12A TLR7 25548411 1713703 Positive_regulation IL12A TLR7 25550115 1734404 Positive_regulation IL12A TLR7 PMC4126180 787229 Positive_regulation IL12A TNF 10049946 1511174 Positive_regulation IL12A TNF 10880525 1516051 Positive_regulation IL12A TNF 11157054 1518354 Positive_regulation IL12A TNF 11157054 1518363 Positive_regulation IL12A TNF 11157054 1518376 Positive_regulation IL12A TNF 11157054 1518379 Positive_regulation IL12A TNF 11854360 1522976 Positive_regulation IL12A TNF 12486107 1525656 Positive_regulation IL12A TNF 14568984 1529245 Positive_regulation IL12A TNF 16258194 1740192 Positive_regulation IL12A TNF 17616976 3039686 Positive_regulation IL12A TNF 17927586 1030470 Positive_regulation IL12A TNF 18086320 109721 Positive_regulation IL12A TNF 18990205 1670771 Positive_regulation IL12A TNF 19156221 2219130 Positive_regulation IL12A TNF 20051129 3110170 Positive_regulation IL12A TNF 20193084 1727970 Positive_regulation IL12A TNF 20831789 366064 Positive_regulation IL12A TNF 21199955 1562319 Positive_regulation IL12A TNF 21298010 2499328 Positive_regulation IL12A TNF 21591259 776247 Positive_regulation IL12A TNF 21829352 3052705 Positive_regulation IL12A TNF 22438968 2612431 Positive_regulation IL12A TNF 22438968 2612436 Positive_regulation IL12A TNF 22506098 1680497 Positive_regulation IL12A TNF 22547990 3152621 Positive_regulation IL12A TNF 22547990 3152633 Positive_regulation IL12A TNF 22621311 2233192 Positive_regulation IL12A TNF 22977683 2115210 Positive_regulation IL12A TNF 23008734 636969 Positive_regulation IL12A TNF 23441175 2756992 Positive_regulation IL12A TNF 23509806 180533 Positive_regulation IL12A TNF 23680127 3204399 Positive_regulation IL12A TNF 23696826 2795299 Positive_regulation IL12A TNF 23760057 2117438 Positive_regulation IL12A TNF 23762085 637557 Positive_regulation IL12A TNF 23762085 637582 Positive_regulation IL12A TNF 23865742 357386 Positive_regulation IL12A TNF 23951210 2833717 Positive_regulation IL12A TNF 23967134 2834647 Positive_regulation IL12A TNF 23967134 2834649 Positive_regulation IL12A TNF 24365457 367474 Positive_regulation IL12A TNF 24406319 840210 Positive_regulation IL12A TNF 24475289 2915445 Positive_regulation IL12A TNF 24578639 3156064 Positive_regulation IL12A TNF 24586980 2928527 Positive_regulation IL12A TNF 24586980 2928528 Positive_regulation IL12A TNF 24586980 2928564 Positive_regulation IL12A TNF 24586980 2928565 Positive_regulation IL12A TNF 24586980 2928566 Positive_regulation IL12A TNF 24586980 2928567 Positive_regulation IL12A TNF 24586980 2928568 Positive_regulation IL12A TNF 24586980 2928681 Positive_regulation IL12A TNF 24614867 2933158 Positive_regulation IL12A TNF 25253920 1762397 Positive_regulation IL12A TNF 25371910 1623348 Positive_regulation IL12A TNF 25384035 3024623 Positive_regulation IL12A TNF 25552899 744126 Positive_regulation IL12A TNF 7722441 1591781 Positive_regulation IL12A TNF 7869050 1592801 Positive_regulation IL12A TNF 8102388 1594061 Positive_regulation IL12A TNF 9104810 1600613 Positive_regulation IL12A TNF 9104810 1600619 Positive_regulation IL12A TNF 9104810 1600620 Positive_regulation IL12A TNF 9348319 1601946 Positive_regulation IL12A TNF 9348319 1601948 Positive_regulation IL12A TNF 9841916 1604733 Positive_regulation IL12A TNFSF10 11257133 1519057 Positive_regulation IL12A TNFSF10 11257133 1519058 Positive_regulation IL12A TNFSF10 11257133 1519069 Positive_regulation IL12A TNFSF10 11257133 1519075 Positive_regulation IL12A TNFSF10 24232092 569067 Positive_regulation IL12A TNFSF10 24367714 2372346 Positive_regulation IL12A TNFSF10 25356750 3020646 Positive_regulation IL12A TP63 14699082 1530524 Positive_regulation IL12A TP63 23221473 3217393 Positive_regulation IL12A TP63 23226202 2723589 Positive_regulation IL12B ALOX5 12417634 1525198 Positive_regulation IL12B ALOX5 23613965 2782921 Positive_regulation IL12B CCL17 22737174 636388 Positive_regulation IL12B CD14 15841259 810594 Positive_regulation IL12B CD14 23223197 3221948 Positive_regulation IL12B EPHB2 15841257 810586 Positive_regulation IL12B EPHB2 18648505 2393186 Positive_regulation IL12B EPHB2 18648505 2393266 Positive_regulation IL12B EPHB2 19667062 1555607 Positive_regulation IL12B EPHB2 19667062 1555684 Positive_regulation IL12B EPHB2 19667062 1555751 Positive_regulation IL12B EPHB2 22537317 355845 Positive_regulation IL12B EPHB2 22537317 355863 Positive_regulation IL12B EPHB2 23853721 1689954 Positive_regulation IL12B EPHB2 23901045 1065501 Positive_regulation IL12B EPHB2 25593648 207072 Positive_regulation IL12B ETV7 25126585 1622937 Positive_regulation IL12B F2R 24015257 2842549 Positive_regulation IL12B FAS 19390568 487398 Positive_regulation IL12B FAS 23762085 637561 Positive_regulation IL12B FAS 24514955 488382 Positive_regulation IL12B FOXO1 24864265 191801 Positive_regulation IL12B IL1B 23209897 97733 Positive_regulation IL12B MAP2K6 23901045 1065508 Positive_regulation IL12B MUC16 25120285 1760444 Positive_regulation IL12B NES 25133189 196814 Positive_regulation IL12B RAB31 24165808 809057 Positive_regulation IL12B RORC 24453425 1756977 Positive_regulation IL12B RORC 25566265 921704 Positive_regulation IL12B STAT4 10587348 1513266 Positive_regulation IL12B STAT4 11034602 1517715 Positive_regulation IL12B STAT4 11405550 1737800 Positive_regulation IL12B STAT4 15526047 2368212 Positive_regulation IL12B STAT4 15699073 1534515 Positive_regulation IL12B STAT4 16520391 1539676 Positive_regulation IL12B STAT4 16717115 1540379 Positive_regulation IL12B STAT4 16717115 1540380 Positive_regulation IL12B STAT4 18803832 111219 Positive_regulation IL12B STAT4 20018088 395456 Positive_regulation IL12B STAT4 20479986 1090097 Positive_regulation IL12B STAT4 20956546 1561003 Positive_regulation IL12B STAT4 21603246 648198 Positive_regulation IL12B STAT4 21635716 122597 Positive_regulation IL12B STAT4 21695280 2324814 Positive_regulation IL12B STAT4 21884628 1490576 Positive_regulation IL12B STAT4 22110388 1058561 Positive_regulation IL12B STAT4 22493582 956820 Positive_regulation IL12B STAT4 22493582 956910 Positive_regulation IL12B STAT4 22729903 1832227 Positive_regulation IL12B STAT4 23285134 2732626 Positive_regulation IL12B STAT4 23469228 2763561 Positive_regulation IL12B STAT4 23469228 2763589 Positive_regulation IL12B STAT4 23555662 2774771 Positive_regulation IL12B STAT4 24058746 1704741 Positive_regulation IL12B STAT4 24058793 1705877 Positive_regulation IL12B STAT4 24058793 1705927 Positive_regulation IL12B STAT4 24058795 1705942 Positive_regulation IL12B STAT4 24058795 1705959 Positive_regulation IL12B STAT4 24097067 1951591 Positive_regulation IL12B STAT4 24188121 1728465 Positive_regulation IL12B STAT4 24363024 488375 Positive_regulation IL12B STAT4 24416649 1708327 Positive_regulation IL12B STAT4 24455433 3151157 Positive_regulation IL12B STAT4 24600449 911325 Positive_regulation IL12B STAT4 25259790 3010647 Positive_regulation IL12B STAT4 7722452 1591970 Positive_regulation IL12B STAT4 7722452 1591980 Positive_regulation IL12B STAT4 8666939 1597348 Positive_regulation IL12B STAT4 9120388 1600995 Positive_regulation IL12B STAT4 9120388 1600996 Positive_regulation IL12B STAT4 9120388 1601024 Positive_regulation IL12B STAT4 9120388 1601028 Positive_regulation IL12B STAT4 9743537 1603896 Positive_regulation IL12B TLR7 12045249 1523544 Positive_regulation IL12B TLR7 12515808 1525675 Positive_regulation IL12B TLR7 12719479 1526966 Positive_regulation IL12B TLR7 15492123 1533665 Positive_regulation IL12B TLR7 15851485 1535778 Positive_regulation IL12B TLR7 15851485 1535779 Positive_regulation IL12B TLR7 15851485 1535780 Positive_regulation IL12B TLR7 15851485 1535781 Positive_regulation IL12B TLR7 15851485 1535951 Positive_regulation IL12B TLR7 16330816 1538757 Positive_regulation IL12B TLR7 16365150 1539039 Positive_regulation IL12B TLR7 16542467 105099 Positive_regulation IL12B TLR7 17371930 1544863 Positive_regulation IL12B TLR7 17371930 1544864 Positive_regulation IL12B TLR7 17371930 1544944 Positive_regulation IL12B TLR7 17371930 1544974 Positive_regulation IL12B TLR7 17371930 1544999 Positive_regulation IL12B TLR7 17485511 1545634 Positive_regulation IL12B TLR7 17485512 1545874 Positive_regulation IL12B TLR7 17786191 2377944 Positive_regulation IL12B TLR7 18086320 109597 Positive_regulation IL12B TLR7 18195076 1548735 Positive_regulation IL12B TLR7 18322684 487898 Positive_regulation IL12B TLR7 18322684 487980 Positive_regulation IL12B TLR7 18411340 1550359 Positive_regulation IL12B TLR7 18442421 1043640 Positive_regulation IL12B TLR7 18461564 807277 Positive_regulation IL12B TLR7 18461564 807365 Positive_regulation IL12B TLR7 18461564 807448 Positive_regulation IL12B TLR7 18461564 807488 Positive_regulation IL12B TLR7 18490488 1551208 Positive_regulation IL12B TLR7 18584038 3074227 Positive_regulation IL12B TLR7 18762568 1551871 Positive_regulation IL12B TLR7 18779348 1551928 Positive_regulation IL12B TLR7 19077314 1727844 Positive_regulation IL12B TLR7 19108028 3231554 Positive_regulation IL12B TLR7 19325820 1087886 Positive_regulation IL12B TLR7 19430534 2416192 Positive_regulation IL12B TLR7 19430534 2416193 Positive_regulation IL12B TLR7 19430534 2416255 Positive_regulation IL12B TLR7 19430534 2416313 Positive_regulation IL12B TLR7 19609356 3044606 Positive_regulation IL12B TLR7 19667062 1555741 Positive_regulation IL12B TLR7 19667062 1555742 Positive_regulation IL12B TLR7 19737867 1556205 Positive_regulation IL12B TLR7 19766674 1042565 Positive_regulation IL12B TLR7 19881508 1953393 Positive_regulation IL12B TLR7 20193084 1727937 Positive_regulation IL12B TLR7 20204070 1213929 Positive_regulation IL12B TLR7 20379390 1214535 Positive_regulation IL12B TLR7 20479986 1090147 Positive_regulation IL12B TLR7 20929569 403185 Positive_regulation IL12B TLR7 20934454 1042647 Positive_regulation IL12B TLR7 21060840 2480851 Positive_regulation IL12B TLR7 21060840 2480917 Positive_regulation IL12B TLR7 21060840 2480981 Positive_regulation IL12B TLR7 21124820 3050094 Positive_regulation IL12B TLR7 21152080 2486109 Positive_regulation IL12B TLR7 21188221 1081688 Positive_regulation IL12B TLR7 21314903 3209800 Positive_regulation IL12B TLR7 21494377 1038059 Positive_regulation IL12B TLR7 21499439 178170 Positive_regulation IL12B TLR7 21533209 2515555 Positive_regulation IL12B TLR7 21994612 3218944 Positive_regulation IL12B TLR7 22110383 1058522 Positive_regulation IL12B TLR7 22116297 1050384 Positive_regulation IL12B TLR7 22164330 97566 Positive_regulation IL12B TLR7 22243920 357086 Positive_regulation IL12B TLR7 22417709 125091 Positive_regulation IL12B TLR7 22427987 2610892 Positive_regulation IL12B TLR7 22513098 125445 Positive_regulation IL12B TLR7 22523644 1680608 Positive_regulation IL12B TLR7 22566937 900276 Positive_regulation IL12B TLR7 22570785 1688532 Positive_regulation IL12B TLR7 22661952 957534 Positive_regulation IL12B TLR7 22815909 2666785 Positive_regulation IL12B TLR7 22863292 366861 Positive_regulation IL12B TLR7 22927956 2681211 Positive_regulation IL12B TLR7 23061052 863715 Positive_regulation IL12B TLR7 23071254 1569669 Positive_regulation IL12B TLR7 23133361 2297618 Positive_regulation IL12B TLR7 23162549 904960 Positive_regulation IL12B TLR7 23162550 905049 Positive_regulation IL12B TLR7 23189270 863862 Positive_regulation IL12B TLR7 23197922 88262 Positive_regulation IL12B TLR7 23209848 2371655 Positive_regulation IL12B TLR7 23221473 3217400 Positive_regulation IL12B TLR7 23299509 1022903 Positive_regulation IL12B TLR7 23382974 2747373 Positive_regulation IL12B TLR7 23396449 2085558 Positive_regulation IL12B TLR7 23408948 2752986 Positive_regulation IL12B TLR7 23421931 590860 Positive_regulation IL12B TLR7 23421931 590930 Positive_regulation IL12B TLR7 23429360 838529 Positive_regulation IL12B TLR7 23448601 535787 Positive_regulation IL12B TLR7 23557436 359079 Positive_regulation IL12B TLR7 23675302 3061434 Positive_regulation IL12B TLR7 23735002 2231729 Positive_regulation IL12B TLR7 23755218 2802018 Positive_regulation IL12B TLR7 23755218 2802019 Positive_regulation IL12B TLR7 23755218 2802020 Positive_regulation IL12B TLR7 23755218 2802088 Positive_regulation IL12B TLR7 23758787 1649612 Positive_regulation IL12B TLR7 23762309 2802954 Positive_regulation IL12B TLR7 23787171 1666852 Positive_regulation IL12B TLR7 23800014 1232246 Positive_regulation IL12B TLR7 23940256 1573356 Positive_regulation IL12B TLR7 23940791 2832482 Positive_regulation IL12B TLR7 23951210 2833766 Positive_regulation IL12B TLR7 23967307 2835795 Positive_regulation IL12B TLR7 23967307 2836119 Positive_regulation IL12B TLR7 23967307 2836120 Positive_regulation IL12B TLR7 23967307 2836203 Positive_regulation IL12B TLR7 24058791 1705816 Positive_regulation IL12B TLR7 24098413 2856217 Positive_regulation IL12B TLR7 24130498 3064599 Positive_regulation IL12B TLR7 24155889 2871048 Positive_regulation IL12B TLR7 24178712 3223564 Positive_regulation IL12B TLR7 24224170 184922 Positive_regulation IL12B TLR7 24282405 909981 Positive_regulation IL12B TLR7 24379524 1756120 Positive_regulation IL12B TLR7 24379524 1756155 Positive_regulation IL12B TLR7 24386404 2903866 Positive_regulation IL12B TLR7 24489947 2917036 Positive_regulation IL12B TLR7 24523723 911035 Positive_regulation IL12B TLR7 24708419 1043509 Positive_regulation IL12B TLR7 24802102 2961888 Positive_regulation IL12B TLR7 24842926 1050000 Positive_regulation IL12B TLR7 24884741 1701756 Positive_regulation IL12B TLR7 24910635 913037 Positive_regulation IL12B TLR7 25071732 926967 Positive_regulation IL12B TLR7 25133189 196845 Positive_regulation IL12B TLR7 25157202 1761780 Positive_regulation IL12B TLR7 25429207 3216528 Positive_regulation IL12B TLR7 25548411 1713713 Positive_regulation IL12B TLR7 25550115 1734415 Positive_regulation IL12B TLR7 PMC4126180 787240 Positive_regulation IL12B TNF 10049946 1511175 Positive_regulation IL12B TNF 10880525 1516052 Positive_regulation IL12B TNF 11157054 1518355 Positive_regulation IL12B TNF 11157054 1518364 Positive_regulation IL12B TNF 11157054 1518377 Positive_regulation IL12B TNF 11157054 1518380 Positive_regulation IL12B TNF 12486107 1525657 Positive_regulation IL12B TNF 14568984 1529248 Positive_regulation IL12B TNF 16258194 1740193 Positive_regulation IL12B TNF 17306038 107824 Positive_regulation IL12B TNF 17616976 3039687 Positive_regulation IL12B TNF 17927586 1030471 Positive_regulation IL12B TNF 18086320 109722 Positive_regulation IL12B TNF 18990205 1670773 Positive_regulation IL12B TNF 19156221 2219131 Positive_regulation IL12B TNF 19815670 3126155 Positive_regulation IL12B TNF 20051129 3110173 Positive_regulation IL12B TNF 20193084 1727972 Positive_regulation IL12B TNF 20831789 366065 Positive_regulation IL12B TNF 21199955 1562320 Positive_regulation IL12B TNF 21298010 2499331 Positive_regulation IL12B TNF 21591259 776252 Positive_regulation IL12B TNF 21829352 3052710 Positive_regulation IL12B TNF 22506098 1680499 Positive_regulation IL12B TNF 22547990 3152623 Positive_regulation IL12B TNF 22547990 3152635 Positive_regulation IL12B TNF 22621311 2233193 Positive_regulation IL12B TNF 22977683 2115213 Positive_regulation IL12B TNF 23008734 636970 Positive_regulation IL12B TNF 23316190 905575 Positive_regulation IL12B TNF 23441175 2756995 Positive_regulation IL12B TNF 23509806 180535 Positive_regulation IL12B TNF 23680127 3204400 Positive_regulation IL12B TNF 23696826 2795300 Positive_regulation IL12B TNF 23760057 2117439 Positive_regulation IL12B TNF 23762085 637560 Positive_regulation IL12B TNF 23762085 637583 Positive_regulation IL12B TNF 23865742 357387 Positive_regulation IL12B TNF 23951210 2833718 Positive_regulation IL12B TNF 23967134 2834648 Positive_regulation IL12B TNF 23967134 2834650 Positive_regulation IL12B TNF 24023721 2843397 Positive_regulation IL12B TNF 24365457 367476 Positive_regulation IL12B TNF 24406319 840211 Positive_regulation IL12B TNF 24475289 2915447 Positive_regulation IL12B TNF 24578639 3156065 Positive_regulation IL12B TNF 24586980 2928530 Positive_regulation IL12B TNF 24586980 2928531 Positive_regulation IL12B TNF 24586980 2928572 Positive_regulation IL12B TNF 24586980 2928573 Positive_regulation IL12B TNF 24586980 2928574 Positive_regulation IL12B TNF 24586980 2928575 Positive_regulation IL12B TNF 24586980 2928576 Positive_regulation IL12B TNF 24586980 2928682 Positive_regulation IL12B TNF 24614867 2933159 Positive_regulation IL12B TNF 25105894 2996098 Positive_regulation IL12B TNF 25253920 1762398 Positive_regulation IL12B TNF 25371910 1623349 Positive_regulation IL12B TNF 25384035 3024624 Positive_regulation IL12B TNF 25552899 744127 Positive_regulation IL12B TNF 7722441 1591782 Positive_regulation IL12B TNF 7869050 1592802 Positive_regulation IL12B TNF 8102388 1594062 Positive_regulation IL12B TNF 9104810 1600614 Positive_regulation IL12B TNF 9104810 1600621 Positive_regulation IL12B TNF 9104810 1600622 Positive_regulation IL12B TNF 9348319 1601947 Positive_regulation IL12B TNF 9348319 1601949 Positive_regulation IL12B TNF 9841916 1604734 Positive_regulation IL12B TNFSF10 11257133 1519059 Positive_regulation IL12B TNFSF10 11257133 1519060 Positive_regulation IL12B TNFSF10 11257133 1519070 Positive_regulation IL12B TNFSF10 11257133 1519076 Positive_regulation IL12B TNFSF10 24232092 569068 Positive_regulation IL12B TNFSF10 24367714 2372347 Positive_regulation IL12B TNFSF10 25356750 3020648 Positive_regulation IL12B TP63 14699082 1530525 Positive_regulation IL12B TP63 23221473 3217404 Positive_regulation IL12B TP63 23226202 2723594 Positive_regulation IL12RB1 STAT4 10952721 1516648 Positive_regulation IL12RB1 STAT4 16542429 3175821 Positive_regulation IL12RB2 STAT4 10952721 1516649 Positive_regulation IL12RB2 STAT4 16542429 3175822 Positive_regulation IL13 CD14 25025695 2989334 Positive_regulation IL13 CHI3L1 23972995 609015 Positive_regulation IL13 CHI3L1 24416647 1708186 Positive_regulation IL13 CTGF 22593760 900837 Positive_regulation IL13 CTGF 22593760 900851 Positive_regulation IL13 CTGF 24173291 1023846 Positive_regulation IL13 CTGF 24376766 2902008 Positive_regulation IL13 EPHB2 15833106 3104951 Positive_regulation IL13 LBP 25025695 2989335 Positive_regulation IL13 MMP7 24279676 856807 Positive_regulation IL13 MUC16 18794337 1552020 Positive_regulation IL13 MUC16 21655064 1635401 Positive_regulation IL13 MUC16 25398130 3027533 Positive_regulation IL13 PLAU 9635840 447107 Positive_regulation IL13 TCN1 23382928 2746813 Positive_regulation IL13 TLR7 11686880 3103176 Positive_regulation IL13 TNF 1311016 1528331 Positive_regulation IL13 TNF 1586593 426051 Positive_regulation IL13 TNF 1643416 702475 Positive_regulation IL13 TNF 1692079 1542186 Positive_regulation IL13 TNF 1717633 1543723 Positive_regulation IL13 TNF 18475440 1743770 Positive_regulation IL13 TNF 1911209 431573 Positive_regulation IL13 TNF 19281078 1071692 Positive_regulation IL13 TNF 19281078 1071694 Positive_regulation IL13 TNF 19742190 1048180 Positive_regulation IL13 TNF 19936089 981553 Positive_regulation IL13 TNF 19951425 353233 Positive_regulation IL13 TNF 2007858 1557300 Positive_regulation IL13 TNF 2022925 1557579 Positive_regulation IL13 TNF 2022925 1557607 Positive_regulation IL13 TNF 2039696 434761 Positive_regulation IL13 TNF 20808962 2473138 Positive_regulation IL13 TNF 21298010 2499334 Positive_regulation IL13 TNF 21829352 3052715 Positive_regulation IL13 TNF 2183871 437508 Positive_regulation IL13 TNF 2183871 437575 Positive_regulation IL13 TNF 2183871 437576 Positive_regulation IL13 TNF 2183871 437617 Positive_regulation IL13 TNF 2258696 1568195 Positive_regulation IL13 TNF 2373990 1572270 Positive_regulation IL13 TNF 2406363 1573701 Positive_regulation IL13 TNF 24143891 3190715 Positive_regulation IL13 TNF 24286242 130917 Positive_regulation IL13 TNF 24688608 2208337 Positive_regulation IL13 TNF 2499653 1576990 Positive_regulation IL13 TNF 2642531 1577567 Positive_regulation IL13 TNF 2659724 1577656 Positive_regulation IL13 TNF 2769183 1577881 Positive_regulation IL13 TNF 2785398 442923 Positive_regulation IL13 TNF 2803928 443144 Positive_regulation IL13 TNF 2833558 1578535 Positive_regulation IL13 TNF 3049617 1425472 Positive_regulation IL13 TNF 3049617 1425473 Positive_regulation IL13 TNF 3049617 1425580 Positive_regulation IL13 TNF 3049617 1425581 Positive_regulation IL13 TNF 3110354 1580054 Positive_regulation IL13 TNF 3137305 1580367 Positive_regulation IL13 TNF 3143799 1580422 Positive_regulation IL13 TNF 3290384 1580788 Positive_regulation IL13 TNF 3309124 1580907 Positive_regulation IL13 TNF 3309124 1580961 Positive_regulation IL13 TNF 3316469 1581021 Positive_regulation IL13 TNF 3411293 1581187 Positive_regulation IL13 TNF 3435706 443502 Positive_regulation IL13 TNF 3491174 1583093 Positive_regulation IL13 TNF 3494807 1583257 Positive_regulation IL13 TNF 3494807 1583258 Positive_regulation IL13 TNF 3494807 1583331 Positive_regulation IL13 TNF 3572302 1583470 Positive_regulation IL13 TNF 3598461 1583528 Positive_regulation IL13 TNF 3598461 1583563 Positive_regulation IL13 TNF 3819645 1583705 Positive_regulation IL13 TNF 8426121 1595197 Positive_regulation IL13 TNF 8478614 1595547 Positive_regulation IL13 TNF PMC2188223 1605396 Positive_regulation IL15 CD14 25025695 2989336 Positive_regulation IL15 EPHB2 19237603 1554187 Positive_regulation IL15 EPHB2 19237603 1554200 Positive_regulation IL15 LBP 25025695 2989337 Positive_regulation IL15 TLR7 11686880 3103186 Positive_regulation IL15 TLR7 18458113 1550798 Positive_regulation IL15 TLR7 18458113 1550818 Positive_regulation IL15 TLR7 24911430 1146461 Positive_regulation IL15 TNF 11219394 98359 Positive_regulation IL15 TNF 1311016 1528332 Positive_regulation IL15 TNF 15225362 101356 Positive_regulation IL15 TNF 15686595 3115416 Positive_regulation IL15 TNF 1586593 426052 Positive_regulation IL15 TNF 1643416 702476 Positive_regulation IL15 TNF 1692079 1542187 Positive_regulation IL15 TNF 1717633 1543724 Positive_regulation IL15 TNF 18475440 1743771 Positive_regulation IL15 TNF 1911209 431574 Positive_regulation IL15 TNF 19742190 1048181 Positive_regulation IL15 TNF 19934004 711860 Positive_regulation IL15 TNF 19934004 711866 Positive_regulation IL15 TNF 19936089 981555 Positive_regulation IL15 TNF 2007858 1557301 Positive_regulation IL15 TNF 2022925 1557580 Positive_regulation IL15 TNF 2022925 1557608 Positive_regulation IL15 TNF 2039696 434762 Positive_regulation IL15 TNF 20808962 2473139 Positive_regulation IL15 TNF 21829352 3052720 Positive_regulation IL15 TNF 2183871 437509 Positive_regulation IL15 TNF 2183871 437577 Positive_regulation IL15 TNF 2183871 437578 Positive_regulation IL15 TNF 2183871 437618 Positive_regulation IL15 TNF 21881590 1630496 Positive_regulation IL15 TNF 22547986 3152579 Positive_regulation IL15 TNF 2258696 1568196 Positive_regulation IL15 TNF 22615502 1044052 Positive_regulation IL15 TNF 23049531 904428 Positive_regulation IL15 TNF 2373990 1572271 Positive_regulation IL15 TNF 23950892 2832722 Positive_regulation IL15 TNF 2406363 1573702 Positive_regulation IL15 TNF 24391825 2904648 Positive_regulation IL15 TNF 2499653 1576991 Positive_regulation IL15 TNF 25548436 1763509 Positive_regulation IL15 TNF 2642531 1577568 Positive_regulation IL15 TNF 2659724 1577657 Positive_regulation IL15 TNF 2769183 1577882 Positive_regulation IL15 TNF 2785398 442924 Positive_regulation IL15 TNF 2803928 443145 Positive_regulation IL15 TNF 2833558 1578536 Positive_regulation IL15 TNF 3049617 1425474 Positive_regulation IL15 TNF 3049617 1425475 Positive_regulation IL15 TNF 3049617 1425582 Positive_regulation IL15 TNF 3049617 1425583 Positive_regulation IL15 TNF 3110354 1580055 Positive_regulation IL15 TNF 3137305 1580368 Positive_regulation IL15 TNF 3143799 1580423 Positive_regulation IL15 TNF 3290384 1580789 Positive_regulation IL15 TNF 3309124 1580908 Positive_regulation IL15 TNF 3309124 1580962 Positive_regulation IL15 TNF 3316469 1581022 Positive_regulation IL15 TNF 3411293 1581188 Positive_regulation IL15 TNF 3435706 443503 Positive_regulation IL15 TNF 3491174 1583094 Positive_regulation IL15 TNF 3494807 1583259 Positive_regulation IL15 TNF 3494807 1583260 Positive_regulation IL15 TNF 3494807 1583332 Positive_regulation IL15 TNF 3572302 1583471 Positive_regulation IL15 TNF 3598461 1583529 Positive_regulation IL15 TNF 3598461 1583564 Positive_regulation IL15 TNF 3819645 1583706 Positive_regulation IL15 TNF 8426121 1595198 Positive_regulation IL15 TNF 8478614 1595548 Positive_regulation IL15 TNF 8478614 1595565 Positive_regulation IL15 TNF PMC2188223 1605397 Positive_regulation IL15 TNF PMC2834061 134539 Positive_regulation IL15 TNF PMC2834061 134540 Positive_regulation IL15 TNF PMC2834061 134541 Positive_regulation IL15 TNF PMC2834061 134544 Positive_regulation IL16 CD14 25025695 2989338 Positive_regulation IL16 LBP 25025695 2989339 Positive_regulation IL16 TLR7 11686880 3103196 Positive_regulation IL16 TNF 1311016 1528333 Positive_regulation IL16 TNF 1586593 426053 Positive_regulation IL16 TNF 1643416 702477 Positive_regulation IL16 TNF 1692079 1542188 Positive_regulation IL16 TNF 1717633 1543725 Positive_regulation IL16 TNF 18475440 1743772 Positive_regulation IL16 TNF 1911209 431575 Positive_regulation IL16 TNF 19742190 1048182 Positive_regulation IL16 TNF 19936089 981557 Positive_regulation IL16 TNF 2007858 1557302 Positive_regulation IL16 TNF 2022925 1557581 Positive_regulation IL16 TNF 2022925 1557609 Positive_regulation IL16 TNF 2039696 434763 Positive_regulation IL16 TNF 20808962 2473140 Positive_regulation IL16 TNF 21829352 3052725 Positive_regulation IL16 TNF 2183871 437510 Positive_regulation IL16 TNF 2183871 437579 Positive_regulation IL16 TNF 2183871 437580 Positive_regulation IL16 TNF 2183871 437619 Positive_regulation IL16 TNF 2258696 1568197 Positive_regulation IL16 TNF 2373990 1572272 Positive_regulation IL16 TNF 2406363 1573703 Positive_regulation IL16 TNF 2499653 1576992 Positive_regulation IL16 TNF 2642531 1577569 Positive_regulation IL16 TNF 2659724 1577658 Positive_regulation IL16 TNF 2769183 1577883 Positive_regulation IL16 TNF 2785398 442925 Positive_regulation IL16 TNF 2803928 443146 Positive_regulation IL16 TNF 2833558 1578537 Positive_regulation IL16 TNF 3049617 1425476 Positive_regulation IL16 TNF 3049617 1425477 Positive_regulation IL16 TNF 3049617 1425584 Positive_regulation IL16 TNF 3049617 1425585 Positive_regulation IL16 TNF 3110354 1580056 Positive_regulation IL16 TNF 3137305 1580369 Positive_regulation IL16 TNF 3143799 1580424 Positive_regulation IL16 TNF 3290384 1580790 Positive_regulation IL16 TNF 3309124 1580909 Positive_regulation IL16 TNF 3309124 1580963 Positive_regulation IL16 TNF 3316469 1581023 Positive_regulation IL16 TNF 3411293 1581189 Positive_regulation IL16 TNF 3435706 443504 Positive_regulation IL16 TNF 3491174 1583095 Positive_regulation IL16 TNF 3494807 1583261 Positive_regulation IL16 TNF 3494807 1583262 Positive_regulation IL16 TNF 3494807 1583333 Positive_regulation IL16 TNF 3572302 1583472 Positive_regulation IL16 TNF 3598461 1583530 Positive_regulation IL16 TNF 3598461 1583565 Positive_regulation IL16 TNF 3819645 1583707 Positive_regulation IL16 TNF 8426121 1595199 Positive_regulation IL16 TNF 8478614 1595549 Positive_regulation IL16 TNF PMC2188223 1605398 Positive_regulation IL17A ADAMTS1 23859810 694902 Positive_regulation IL17A ADAMTS1 23977238 2839390 Positive_regulation IL17A CAPN8 22046434 2567772 Positive_regulation IL17A CAPN8 22046434 2567842 Positive_regulation IL17A CD14 PMC3508816 1702682 Positive_regulation IL17A EPHB2 20976214 2479443 Positive_regulation IL17A EPHB2 23956759 638347 Positive_regulation IL17A EPHB2 24376862 2902581 Positive_regulation IL17A FOXO1 21825017 1564539 Positive_regulation IL17A FOXO1 21825017 1564585 Positive_regulation IL17A FUT4 25180025 1761892 Positive_regulation IL17A HES2 23935505 3063417 Positive_regulation IL17A IL1B 18591407 1551458 Positive_regulation IL17A IL1B 24221190 3126133 Positive_regulation IL17A JAG1 24435677 809079 Positive_regulation IL17A MAP2K6 24400116 2905768 Positive_regulation IL17A MIP 20544034 2452630 Positive_regulation IL17A MIP 21699708 1626386 Positive_regulation IL17A MIP 21747807 923185 Positive_regulation IL17A MUC16 21695271 2530173 Positive_regulation IL17A MUC16 23342289 82663 Positive_regulation IL17A MUC16 25398130 3027548 Positive_regulation IL17A PTGER2 19273625 1554272 Positive_regulation IL17A PTGER2 21946663 1041835 Positive_regulation IL17A RNASE7 23555696 2774906 Positive_regulation IL17A RNASE7 23555696 2774915 Positive_regulation IL17A RNASE7 23555696 2774916 Positive_regulation IL17A RNASE7 23555696 2774924 Positive_regulation IL17A RNASE7 23555696 2774932 Positive_regulation IL17A RNASE7 23555696 2774933 Positive_regulation IL17A RNASE7 24747887 2955896 Positive_regulation IL17A RORC 19188499 1553747 Positive_regulation IL17A RORC 21131965 1954686 Positive_regulation IL17A RORC 21825017 1564538 Positive_regulation IL17A RORC 21825017 1564552 Positive_regulation IL17A RORC 22473038 1957037 Positive_regulation IL17A RORC 24362892 1959634 Positive_regulation IL17A RORC 24395888 1574427 Positive_regulation IL17A RORC 24611151 588852 Positive_regulation IL17A RORC 24611151 588853 Positive_regulation IL17A RORC 25405356 3027963 Positive_regulation IL17A S100A7 23193414 1156329 Positive_regulation IL17A S100A7 23197904 88217 Positive_regulation IL17A S100A7 23555696 2774914 Positive_regulation IL17A S100A7 25140116 1761017 Positive_regulation IL17A STAT4 20454646 1215276 Positive_regulation IL17A TCN1 22750193 1492587 Positive_regulation IL17A TLR7 20374638 328767 Positive_regulation IL17A TLR7 21533209 2515566 Positive_regulation IL17A TLR7 22417709 125237 Positive_regulation IL17A TLR7 23316190 905562 Positive_regulation IL17A TLR7 23505568 2767101 Positive_regulation IL17A TLR7 24358364 2899745 Positive_regulation IL17A TLR7 24740301 2954621 Positive_regulation IL17A TLR7 24740301 2954632 Positive_regulation IL17A TNF 11299057 98395 Positive_regulation IL17A TNF 16818675 1541091 Positive_regulation IL17A TNF 17306038 107828 Positive_regulation IL17A TNF 19519923 113493 Positive_regulation IL17A TNF 19627579 116160 Positive_regulation IL17A TNF 19627579 116161 Positive_regulation IL17A TNF 19759900 2426561 Positive_regulation IL17A TNF 19851470 175898 Positive_regulation IL17A TNF 20101303 1043908 Positive_regulation IL17A TNF 20374638 328796 Positive_regulation IL17A TNF 20544034 2452627 Positive_regulation IL17A TNF 21235788 3213850 Positive_regulation IL17A TNF 21294856 291666 Positive_regulation IL17A TNF 21294864 121428 Positive_regulation IL17A TNF 21801431 123341 Positive_regulation IL17A TNF 22855687 902731 Positive_regulation IL17A TNF 23028407 2219743 Positive_regulation IL17A TNF 23063332 1040702 Positive_regulation IL17A TNF 23063332 1040705 Positive_regulation IL17A TNF 23197904 88225 Positive_regulation IL17A TNF 23301223 89174 Positive_regulation IL17A TNF 23349929 2744081 Positive_regulation IL17A TNF 23515267 629879 Positive_regulation IL17A TNF 23977238 2839383 Positive_regulation IL17A TNF 23977238 2839397 Positive_regulation IL17A TNF 23991210 2841275 Positive_regulation IL17A TNF 24084730 1113168 Positive_regulation IL17A TNF 24086143 2350936 Positive_regulation IL17A TNF 24086143 2350942 Positive_regulation IL17A TNF 24221190 3126132 Positive_regulation IL17A TNF 24302815 1755339 Positive_regulation IL17A TNF 24358317 2899534 Positive_regulation IL17A TNF 24385944 1039805 Positive_regulation IL17A TNF 24465207 3066057 Positive_regulation IL17A TNF 24744681 3156526 Positive_regulation IL17A TNF 24788826 2959742 Positive_regulation IL17A TNF 24868166 2122981 Positive_regulation IL17A TNF 25295284 1623299 Positive_regulation IL17A TP63 18936235 1552471 Positive_regulation IL17A TP63 20176803 1557441 Positive_regulation IL17A ZBTB16 22473038 1957038 Positive_regulation IL17B IL1B 25152827 1083035 Positive_regulation IL17B TNF 25152827 1083034 Positive_regulation IL17C IL1B 25152827 1083037 Positive_regulation IL17C RNASE7 23555696 2774918 Positive_regulation IL17C TNF 25152827 1083036 Positive_regulation IL17D F2R 23384341 660393 Positive_regulation IL17D TLR7 22911108 3058854 Positive_regulation IL17D TNFSF10 24155891 2871149 Positive_regulation IL17D TNFSF10 24155891 2871150 Positive_regulation IL17D TNFSF10 24155891 2871151 Positive_regulation IL17D TNFSF10 24155891 2871181 Positive_regulation IL17F TLR7 23505568 2767090 Positive_regulation IL18 CD14 25025695 2989340 Positive_regulation IL18 FAS 22891066 903444 Positive_regulation IL18 FAS 23762085 637564 Positive_regulation IL18 FAS 24115947 909161 Positive_regulation IL18 IL1B 19954533 2232850 Positive_regulation IL18 IL1B 23915129 359218 Positive_regulation IL18 IL1B 25436109 1161838 Positive_regulation IL18 LBP 25025695 2989341 Positive_regulation IL18 MIP 14970180 1531403 Positive_regulation IL18 STAT4 10190904 1511378 Positive_regulation IL18 STAT4 20053303 118057 Positive_regulation IL18 TLR7 11686880 3103206 Positive_regulation IL18 TLR7 18195076 1548591 Positive_regulation IL18 TLR7 18195076 1548636 Positive_regulation IL18 TLR7 19461888 3043851 Positive_regulation IL18 TLR7 21994762 3220175 Positive_regulation IL18 TLR7 22216838 660105 Positive_regulation IL18 TLR7 23484118 179465 Positive_regulation IL18 TLR7 23484118 179486 Positive_regulation IL18 TNF 11094408 98052 Positive_regulation IL18 TNF 11489953 1520477 Positive_regulation IL18 TNF 11489953 1520478 Positive_regulation IL18 TNF 11489953 1520485 Positive_regulation IL18 TNF 11489953 1520490 Positive_regulation IL18 TNF 11879550 98717 Positive_regulation IL18 TNF 11879550 98723 Positive_regulation IL18 TNF 12110119 98932 Positive_regulation IL18 TNF 12110156 99323 Positive_regulation IL18 TNF 1311016 1528334 Positive_regulation IL18 TNF 1396471 791930 Positive_regulation IL18 TNF 15285802 1654728 Positive_regulation IL18 TNF 1586593 426054 Positive_regulation IL18 TNF 16258194 1740194 Positive_regulation IL18 TNF 1643416 702478 Positive_regulation IL18 TNF 16563174 105644 Positive_regulation IL18 TNF 1692079 1542189 Positive_regulation IL18 TNF 1717633 1543726 Positive_regulation IL18 TNF 18226185 109995 Positive_regulation IL18 TNF 18475440 1743773 Positive_regulation IL18 TNF 1911209 431576 Positive_regulation IL18 TNF 19742190 1048183 Positive_regulation IL18 TNF 19936089 981559 Positive_regulation IL18 TNF 2007858 1557303 Positive_regulation IL18 TNF 2022925 1557582 Positive_regulation IL18 TNF 2022925 1557610 Positive_regulation IL18 TNF 2039696 434764 Positive_regulation IL18 TNF 20808962 2473141 Positive_regulation IL18 TNF 21829352 3052730 Positive_regulation IL18 TNF 2183871 437511 Positive_regulation IL18 TNF 2183871 437581 Positive_regulation IL18 TNF 2183871 437582 Positive_regulation IL18 TNF 2183871 437620 Positive_regulation IL18 TNF 22536153 3056420 Positive_regulation IL18 TNF 2258696 1568198 Positive_regulation IL18 TNF 22596175 729812 Positive_regulation IL18 TNF 22596175 729815 Positive_regulation IL18 TNF 23441175 2756998 Positive_regulation IL18 TNF 23696826 2795301 Positive_regulation IL18 TNF 2373990 1572273 Positive_regulation IL18 TNF 23762085 637563 Positive_regulation IL18 TNF 23762085 637584 Positive_regulation IL18 TNF 23915129 359217 Positive_regulation IL18 TNF 2406363 1573704 Positive_regulation IL18 TNF 24762050 132312 Positive_regulation IL18 TNF 24762050 132313 Positive_regulation IL18 TNF 24762050 132320 Positive_regulation IL18 TNF 24762050 132326 Positive_regulation IL18 TNF 2499653 1576993 Positive_regulation IL18 TNF 2642531 1577570 Positive_regulation IL18 TNF 2659724 1577659 Positive_regulation IL18 TNF 2769183 1577884 Positive_regulation IL18 TNF 2785398 442926 Positive_regulation IL18 TNF 2803928 443147 Positive_regulation IL18 TNF 2833558 1578538 Positive_regulation IL18 TNF 3049617 1425478 Positive_regulation IL18 TNF 3049617 1425479 Positive_regulation IL18 TNF 3049617 1425586 Positive_regulation IL18 TNF 3049617 1425587 Positive_regulation IL18 TNF 3110354 1580057 Positive_regulation IL18 TNF 3137305 1580370 Positive_regulation IL18 TNF 3143799 1580425 Positive_regulation IL18 TNF 3290384 1580791 Positive_regulation IL18 TNF 3309124 1580910 Positive_regulation IL18 TNF 3309124 1580964 Positive_regulation IL18 TNF 3316469 1581024 Positive_regulation IL18 TNF 3411293 1581190 Positive_regulation IL18 TNF 3435706 443505 Positive_regulation IL18 TNF 3491174 1583096 Positive_regulation IL18 TNF 3494807 1583263 Positive_regulation IL18 TNF 3494807 1583264 Positive_regulation IL18 TNF 3494807 1583334 Positive_regulation IL18 TNF 3572302 1583473 Positive_regulation IL18 TNF 3598461 1583531 Positive_regulation IL18 TNF 3598461 1583566 Positive_regulation IL18 TNF 3819645 1583708 Positive_regulation IL18 TNF 8426121 1595200 Positive_regulation IL18 TNF 8478614 1595550 Positive_regulation IL18 TNF PMC2188223 1605399 Positive_regulation IL18 TNFSF10 11257133 1519066 Positive_regulation IL18 TNFSF10 25356750 3020650 Positive_regulation IL18BP TNF 24762050 132321 Positive_regulation IL18R1 IL1B 23717664 2798680 Positive_regulation IL18RAP IL1B 23717664 2798681 Positive_regulation IL19 CD14 25025695 2989342 Positive_regulation IL19 LBP 25025695 2989343 Positive_regulation IL19 TLR7 11686880 3103216 Positive_regulation IL19 TNF 1311016 1528335 Positive_regulation IL19 TNF 1586593 426055 Positive_regulation IL19 TNF 1643416 702479 Positive_regulation IL19 TNF 1692079 1542190 Positive_regulation IL19 TNF 1717633 1543727 Positive_regulation IL19 TNF 18475440 1743774 Positive_regulation IL19 TNF 1911209 431577 Positive_regulation IL19 TNF 19742190 1048184 Positive_regulation IL19 TNF 19936089 981561 Positive_regulation IL19 TNF 2007858 1557304 Positive_regulation IL19 TNF 2022925 1557583 Positive_regulation IL19 TNF 2022925 1557611 Positive_regulation IL19 TNF 2039696 434765 Positive_regulation IL19 TNF 20808962 2473142 Positive_regulation IL19 TNF 21829352 3052735 Positive_regulation IL19 TNF 2183871 437512 Positive_regulation IL19 TNF 2183871 437583 Positive_regulation IL19 TNF 2183871 437584 Positive_regulation IL19 TNF 2183871 437621 Positive_regulation IL19 TNF 2258696 1568199 Positive_regulation IL19 TNF 22844641 1082591 Positive_regulation IL19 TNF 23468852 2759825 Positive_regulation IL19 TNF 23468852 2759836 Positive_regulation IL19 TNF 2373990 1572274 Positive_regulation IL19 TNF 2406363 1573705 Positive_regulation IL19 TNF 2499653 1576994 Positive_regulation IL19 TNF 2642531 1577571 Positive_regulation IL19 TNF 2659724 1577660 Positive_regulation IL19 TNF 2769183 1577885 Positive_regulation IL19 TNF 2785398 442927 Positive_regulation IL19 TNF 2803928 443148 Positive_regulation IL19 TNF 2833558 1578539 Positive_regulation IL19 TNF 3049617 1425480 Positive_regulation IL19 TNF 3049617 1425481 Positive_regulation IL19 TNF 3049617 1425588 Positive_regulation IL19 TNF 3049617 1425589 Positive_regulation IL19 TNF 3110354 1580058 Positive_regulation IL19 TNF 3137305 1580371 Positive_regulation IL19 TNF 3143799 1580426 Positive_regulation IL19 TNF 3290384 1580792 Positive_regulation IL19 TNF 3309124 1580911 Positive_regulation IL19 TNF 3309124 1580965 Positive_regulation IL19 TNF 3316469 1581025 Positive_regulation IL19 TNF 3411293 1581191 Positive_regulation IL19 TNF 3435706 443506 Positive_regulation IL19 TNF 3491174 1583097 Positive_regulation IL19 TNF 3494807 1583265 Positive_regulation IL19 TNF 3494807 1583266 Positive_regulation IL19 TNF 3494807 1583335 Positive_regulation IL19 TNF 3572302 1583474 Positive_regulation IL19 TNF 3598461 1583532 Positive_regulation IL19 TNF 3598461 1583567 Positive_regulation IL19 TNF 3819645 1583709 Positive_regulation IL19 TNF 8426121 1595201 Positive_regulation IL19 TNF 8478614 1595551 Positive_regulation IL19 TNF PMC2188223 1605400 Positive_regulation IL1A ADAMTS1 20645923 147900 Positive_regulation IL1A ADAMTS1 22454637 680244 Positive_regulation IL1A ANGPT1 24563688 2923989 Positive_regulation IL1A ANKRD1 22808421 3130956 Positive_regulation IL1A ARSA 25045211 1760201 Positive_regulation IL1A AXIN2 10496353 415381 Positive_regulation IL1A CAPN8 21106488 1031236 Positive_regulation IL1A CAPN8 24022484 1208145 Positive_regulation IL1A CAPN8 24022484 1208161 Positive_regulation IL1A CAPN8 24024155 3093330 Positive_regulation IL1A CD14 12061425 1738149 Positive_regulation IL1A CD14 20946675 1723275 Positive_regulation IL1A CD14 20946675 1723314 Positive_regulation IL1A CD14 20946675 1723335 Positive_regulation IL1A CD14 21352551 1626336 Positive_regulation IL1A CD14 22489138 1095385 Positive_regulation IL1A CD14 24278676 3150027 Positive_regulation IL1A CD14 PMC3508816 1702685 Positive_regulation IL1A CHI3L1 20029652 178135 Positive_regulation IL1A CTGF 24015193 2842206 Positive_regulation IL1A EDN2 24117726 34106 Positive_regulation IL1A EFNB1 20979661 1897741 Positive_regulation IL1A EFNB1 20979661 1897742 Positive_regulation IL1A EFNB1 20979661 1897745 Positive_regulation IL1A EPHB2 11136824 1518279 Positive_regulation IL1A EPHB2 12482999 1633207 Positive_regulation IL1A EPHB2 12482999 1633208 Positive_regulation IL1A EPHB2 12482999 1633753 Positive_regulation IL1A EPHB2 14613528 3177960 Positive_regulation IL1A EPHB2 16504015 278978 Positive_regulation IL1A EPHB2 20137095 375158 Positive_regulation IL1A EPHB2 20137095 375168 Positive_regulation IL1A EPHB2 20137095 375175 Positive_regulation IL1A EPHB2 20830230 1711857 Positive_regulation IL1A EPHB2 21319222 1022035 Positive_regulation IL1A EPHB2 22114704 2573491 Positive_regulation IL1A EPHB2 22615852 2643868 Positive_regulation IL1A EPHB2 22806180 1644454 Positive_regulation IL1A EPHB2 22824323 1664549 Positive_regulation IL1A EPHB2 22867088 2233224 Positive_regulation IL1A EPHB2 23271927 1714652 Positive_regulation IL1A EPHB2 23300722 2735643 Positive_regulation IL1A EPHB2 23549814 3233613 Positive_regulation IL1A EPHB2 23878744 1150832 Positive_regulation IL1A EPHB2 23901045 1065510 Positive_regulation IL1A EPHB2 23956505 1754518 Positive_regulation IL1A EPHB2 24349206 2897072 Positive_regulation IL1A EPHB2 24722253 2951098 Positive_regulation IL1A EPHB2 25166426 3003723 Positive_regulation IL1A EPHB2 25598661 1716874 Positive_regulation IL1A F2R 19852794 1227765 Positive_regulation IL1A F2R 19852794 1227783 Positive_regulation IL1A FAS 10704145 1737018 Positive_regulation IL1A FAS 15292926 424858 Positive_regulation IL1A FAS 15762980 1162699 Positive_regulation IL1A FAS 20565784 1626083 Positive_regulation IL1A FAS 21251296 1697022 Positive_regulation IL1A FAS 9334358 1601704 Positive_regulation IL1A FAS 9334376 1601784 Positive_regulation IL1A FOXO1 19651810 710714 Positive_regulation IL1A FOXO1 19651810 710715 Positive_regulation IL1A FOXO1 19651810 710716 Positive_regulation IL1A FOXO1 19651810 710717 Positive_regulation IL1A FOXO1 19651810 710718 Positive_regulation IL1A FOXO1 19651810 710719 Positive_regulation IL1A FOXO1 19651810 710720 Positive_regulation IL1A FOXO1 19651810 710721 Positive_regulation IL1A FOXO1 19651810 710722 Positive_regulation IL1A FOXO1 19651810 710723 Positive_regulation IL1A FOXO1 19651810 710729 Positive_regulation IL1A FOXO1 19651810 710733 Positive_regulation IL1A FOXO1 19651810 710739 Positive_regulation IL1A FOXO1 19651810 710740 Positive_regulation IL1A FOXO1 19651810 710748 Positive_regulation IL1A FOXO1 19651810 710749 Positive_regulation IL1A FOXO1 19651810 710754 Positive_regulation IL1A FOXO1 19651810 710755 Positive_regulation IL1A FOXO1 19651810 710764 Positive_regulation IL1A FOXO1 19651810 710765 Positive_regulation IL1A FOXO1 19651810 710767 Positive_regulation IL1A FOXO1 19651810 710774 Positive_regulation IL1A FOXO1 20426802 1723012 Positive_regulation IL1A FOXO1 22084407 1566029 Positive_regulation IL1A FOXO1 24864265 191774 Positive_regulation IL1A FOXO1 24864265 191787 Positive_regulation IL1A IL1B 22039457 2565516 Positive_regulation IL1A IL1B 23936458 2830975 Positive_regulation IL1A IL1B 24156755 380456 Positive_regulation IL1A IL1B 24618842 2933384 Positive_regulation IL1A IL1R2 10637275 1514179 Positive_regulation IL1A IL1R2 20847813 1747870 Positive_regulation IL1A JAG1 21637390 1038172 Positive_regulation IL1A LBP 23125878 1641424 Positive_regulation IL1A LBP 7504060 1588755 Positive_regulation IL1A MAP2K6 12482999 1633214 Positive_regulation IL1A MAP2K6 12482999 1633759 Positive_regulation IL1A MAP2K6 21319222 1022041 Positive_regulation IL1A MAP2K6 23901045 1065516 Positive_regulation IL1A MAP2K6 23956505 1754524 Positive_regulation IL1A MIP 11085746 1517929 Positive_regulation IL1A MIP 21811611 2539724 Positive_regulation IL1A MIP 24058610 2848247 Positive_regulation IL1A MMP28 17096856 1695563 Positive_regulation IL1A MMP28 19309495 3226028 Positive_regulation IL1A MMP28 19375502 1731659 Positive_regulation IL1A MMP28 19567787 2251165 Positive_regulation IL1A MMP28 19919704 117796 Positive_regulation IL1A MMP28 20799933 119765 Positive_regulation IL1A MMP28 21151531 1081312 Positive_regulation IL1A MMP28 21217769 12324 Positive_regulation IL1A MMP28 23342250 491482 Positive_regulation IL1A MMP28 23342250 491483 Positive_regulation IL1A MMP28 23342250 491484 Positive_regulation IL1A MMP28 24817792 1758486 Positive_regulation IL1A MMP7 17096856 1695578 Positive_regulation IL1A MMP7 17760968 108942 Positive_regulation IL1A MMP7 19309495 3226043 Positive_regulation IL1A MMP7 19567787 2251180 Positive_regulation IL1A MMP7 19919704 117811 Positive_regulation IL1A MMP7 20799933 119780 Positive_regulation IL1A MMP7 21151531 1081329 Positive_regulation IL1A MMP7 21217769 12339 Positive_regulation IL1A MMP7 23342250 491528 Positive_regulation IL1A MMP7 23342250 491529 Positive_regulation IL1A MMP7 23342250 491530 Positive_regulation IL1A MMP7 24817792 1758501 Positive_regulation IL1A PLAU 22710193 2253028 Positive_regulation IL1A PLAU 22963460 1698820 Positive_regulation IL1A PLAU 23502002 2086215 Positive_regulation IL1A PLAU 23502002 2086222 Positive_regulation IL1A PLAU PMC2834060 134531 Positive_regulation IL1A PPBP 23136963 412326 Positive_regulation IL1A PTGER2 25237386 1651013 Positive_regulation IL1A PTGER2 25237386 1651024 Positive_regulation IL1A RCAN1 22397398 1661326 Positive_regulation IL1A RORC 24013901 2842174 Positive_regulation IL1A S100A7 23193414 1156331 Positive_regulation IL1A S100A7 25010647 2987985 Positive_regulation IL1A S100B 19292913 1695979 Positive_regulation IL1A S100B 19292913 1695985 Positive_regulation IL1A S100B 20508809 512947 Positive_regulation IL1A S100B 20827421 513002 Positive_regulation IL1A S100B 20862385 513126 Positive_regulation IL1A S100B 20862385 513134 Positive_regulation IL1A S100B 22022205 1628171 Positive_regulation IL1A S100B 23866266 1666886 Positive_regulation IL1A SPHK1 21310085 1657771 Positive_regulation IL1A SPHK1 24464131 1959676 Positive_regulation IL1A SPHK1 24464131 1959677 Positive_regulation IL1A TLR7 14699082 1530512 Positive_regulation IL1A TLR7 19150378 3206775 Positive_regulation IL1A TLR7 19212823 3090550 Positive_regulation IL1A TLR7 19461888 3043861 Positive_regulation IL1A TLR7 19503839 2418616 Positive_regulation IL1A TLR7 19826485 2428632 Positive_regulation IL1A TLR7 20383149 1953832 Positive_regulation IL1A TLR7 20495003 1187965 Positive_regulation IL1A TLR7 20495003 1187974 Positive_regulation IL1A TLR7 20929569 403339 Positive_regulation IL1A TLR7 21085613 3049996 Positive_regulation IL1A TLR7 21152080 2486092 Positive_regulation IL1A TLR7 21188221 1081699 Positive_regulation IL1A TLR7 21533209 2515524 Positive_regulation IL1A TLR7 21733175 1658663 Positive_regulation IL1A TLR7 21887254 2548883 Positive_regulation IL1A TLR7 21994762 3220185 Positive_regulation IL1A TLR7 22164330 97567 Positive_regulation IL1A TLR7 22206014 2584242 Positive_regulation IL1A TLR7 22216838 660115 Positive_regulation IL1A TLR7 22291094 1567001 Positive_regulation IL1A TLR7 22389743 2371240 Positive_regulation IL1A TLR7 22484733 1957093 Positive_regulation IL1A TLR7 22484733 1957164 Positive_regulation IL1A TLR7 22484733 1957204 Positive_regulation IL1A TLR7 22513098 125455 Positive_regulation IL1A TLR7 22529966 2620765 Positive_regulation IL1A TLR7 22530722 3210218 Positive_regulation IL1A TLR7 22611515 1082562 Positive_regulation IL1A TLR7 22649499 2646598 Positive_regulation IL1A TLR7 22751696 723562 Positive_regulation IL1A TLR7 22751696 723563 Positive_regulation IL1A TLR7 22751696 723564 Positive_regulation IL1A TLR7 22751696 723565 Positive_regulation IL1A TLR7 22751696 723657 Positive_regulation IL1A TLR7 22751696 723677 Positive_regulation IL1A TLR7 22751696 723697 Positive_regulation IL1A TLR7 22802904 2219240 Positive_regulation IL1A TLR7 22919647 863463 Positive_regulation IL1A TLR7 22937165 2683155 Positive_regulation IL1A TLR7 23028609 2691858 Positive_regulation IL1A TLR7 23036692 126940 Positive_regulation IL1A TLR7 23055923 3059533 Positive_regulation IL1A TLR7 23110254 746936 Positive_regulation IL1A TLR7 23110254 746950 Positive_regulation IL1A TLR7 23239947 3229359 Positive_regulation IL1A TLR7 23382974 2747402 Positive_regulation IL1A TLR7 23557436 359089 Positive_regulation IL1A TLR7 23570314 1146311 Positive_regulation IL1A TLR7 23633957 3060874 Positive_regulation IL1A TLR7 23658628 2789264 Positive_regulation IL1A TLR7 23658628 2789276 Positive_regulation IL1A TLR7 23666718 780742 Positive_regulation IL1A TLR7 23762026 3062126 Positive_regulation IL1A TLR7 23762309 2802964 Positive_regulation IL1A TLR7 23839215 1732397 Positive_regulation IL1A TLR7 23898332 908477 Positive_regulation IL1A TLR7 23937571 357434 Positive_regulation IL1A TLR7 24011352 297910 Positive_regulation IL1A TLR7 24011352 297921 Positive_regulation IL1A TLR7 24178712 3223565 Positive_regulation IL1A TLR7 24204973 2875041 Positive_regulation IL1A TLR7 24204973 2875059 Positive_regulation IL1A TLR7 24204973 2875060 Positive_regulation IL1A TLR7 24205068 2875189 Positive_regulation IL1A TLR7 24205068 2875204 Positive_regulation IL1A TLR7 24224170 184932 Positive_regulation IL1A TLR7 24285369 3138857 Positive_regulation IL1A TLR7 24352507 1940002 Positive_regulation IL1A TLR7 24367258 3065322 Positive_regulation IL1A TLR7 24400125 2905912 Positive_regulation IL1A TLR7 24533162 2922430 Positive_regulation IL1A TLR7 24886384 3124693 Positive_regulation IL1A TLR7 24911430 1146421 Positive_regulation IL1A TLR7 24911430 1146434 Positive_regulation IL1A TLR7 24942685 1043313 Positive_regulation IL1A TLR7 24966466 1759790 Positive_regulation IL1A TLR7 24987391 926844 Positive_regulation IL1A TLR7 25071732 927022 Positive_regulation IL1A TLR7 25071732 927064 Positive_regulation IL1A TLR7 25136575 197188 Positive_regulation IL1A TLR7 25161655 913891 Positive_regulation IL1A TLR7 25340046 950134 Positive_regulation IL1A TLR7 25340046 950167 Positive_regulation IL1A TLR7 25485543 3032614 Positive_regulation IL1A TLR7 25486008 3032721 Positive_regulation IL1A TLR7 25541965 3035942 Positive_regulation IL1A TLR7 PMC3194144 134675 Positive_regulation IL1A TNF 10377187 1512015 Positive_regulation IL1A TNF 10748240 1515104 Positive_regulation IL1A TNF 11219393 98351 Positive_regulation IL1A TNF 12106499 98927 Positive_regulation IL1A TNF 12391014 1525087 Positive_regulation IL1A TNF 12437786 1733981 Positive_regulation IL1A TNF 12493071 658442 Positive_regulation IL1A TNF 15142264 101190 Positive_regulation IL1A TNF 15142268 101203 Positive_regulation IL1A TNF 15180890 101214 Positive_regulation IL1A TNF 15611291 1534043 Positive_regulation IL1A TNF 15642143 102396 Positive_regulation IL1A TNF 15642151 102480 Positive_regulation IL1A TNF 1586593 426010 Positive_regulation IL1A TNF 1586593 426056 Positive_regulation IL1A TNF 1586593 426057 Positive_regulation IL1A TNF 1586593 426070 Positive_regulation IL1A TNF 15946381 3105034 Positive_regulation IL1A TNF 16277688 104759 Positive_regulation IL1A TNF 16277701 104845 Positive_regulation IL1A TNF 16567387 1539749 Positive_regulation IL1A TNF 16800873 1722653 Positive_regulation IL1A TNF 16818675 1541125 Positive_regulation IL1A TNF 16859503 106265 Positive_regulation IL1A TNF 16859534 106333 Positive_regulation IL1A TNF 17177994 107708 Positive_regulation IL1A TNF 17965763 810774 Positive_regulation IL1A TNF 18472950 1743293 Positive_regulation IL1A TNF 18475439 1743642 Positive_regulation IL1A TNF 18475468 1743846 Positive_regulation IL1A TNF 18475483 1743984 Positive_regulation IL1A TNF 18475680 1745380 Positive_regulation IL1A TNF 18475682 1745393 Positive_regulation IL1A TNF 18475751 1746332 Positive_regulation IL1A TNF 18523535 1733573 Positive_regulation IL1A TNF 18591389 706356 Positive_regulation IL1A TNF 19065997 3208645 Positive_regulation IL1A TNF 19198593 1952249 Positive_regulation IL1A TNF 19435506 113224 Positive_regulation IL1A TNF 19435506 113225 Positive_regulation IL1A TNF 19463182 352905 Positive_regulation IL1A TNF 19672457 1746655 Positive_regulation IL1A TNF 19918368 1136661 Positive_regulation IL1A TNF 19922639 117872 Positive_regulation IL1A TNF 20049078 1022001 Positive_regulation IL1A TNF 20142991 845598 Positive_regulation IL1A TNF 20156727 809183 Positive_regulation IL1A TNF 20165718 1497208 Positive_regulation IL1A TNF 20693346 716062 Positive_regulation IL1A TNF 20836881 508209 Positive_regulation IL1A TNF 20975042 1561074 Positive_regulation IL1A TNF 21079906 1644335 Positive_regulation IL1A TNF 21131967 1954735 Positive_regulation IL1A TNF 21131967 1954740 Positive_regulation IL1A TNF 21278785 12441 Positive_regulation IL1A TNF 21321416 1044979 Positive_regulation IL1A TNF 21424610 1668501 Positive_regulation IL1A TNF 21445283 3177014 Positive_regulation IL1A TNF 21694944 1140167 Positive_regulation IL1A TNF 21696573 1658624 Positive_regulation IL1A TNF 21808655 813055 Positive_regulation IL1A TNF 21860543 1749395 Positive_regulation IL1A TNF 21896197 396364 Positive_regulation IL1A TNF 21977313 799199 Positive_regulation IL1A TNF 21978632 1697866 Positive_regulation IL1A TNF 22002242 488151 Positive_regulation IL1A TNF 22069489 2569233 Positive_regulation IL1A TNF 22096364 1628322 Positive_regulation IL1A TNF 22322095 1882595 Positive_regulation IL1A TNF 22347541 1675378 Positive_regulation IL1A TNF 22471522 150148 Positive_regulation IL1A TNF 22500177 1144845 Positive_regulation IL1A TNF 22547986 3152575 Positive_regulation IL1A TNF 22547990 3152625 Positive_regulation IL1A TNF 22655170 1703035 Positive_regulation IL1A TNF 22661946 951851 Positive_regulation IL1A TNF 22682420 126127 Positive_regulation IL1A TNF 22761877 2659058 Positive_regulation IL1A TNF 22768286 2660405 Positive_regulation IL1A TNF 22768286 2660436 Positive_regulation IL1A TNF 22802918 2218969 Positive_regulation IL1A TNF 22816003 2371458 Positive_regulation IL1A TNF 22929089 1036453 Positive_regulation IL1A TNF 23028407 2219745 Positive_regulation IL1A TNF 23072510 126985 Positive_regulation IL1A TNF 23072510 126998 Positive_regulation IL1A TNF 23118903 2712088 Positive_regulation IL1A TNF 23208413 2110588 Positive_regulation IL1A TNF 23484099 179441 Positive_regulation IL1A TNF 23488692 3129578 Positive_regulation IL1A TNF 23509754 180087 Positive_regulation IL1A TNF 23516523 2768199 Positive_regulation IL1A TNF 23567618 1642644 Positive_regulation IL1A TNF 23631691 3215583 Positive_regulation IL1A TNF 23634700 1666644 Positive_regulation IL1A TNF 23680172 1626984 Positive_regulation IL1A TNF 23762085 637585 Positive_regulation IL1A TNF 23840908 2818816 Positive_regulation IL1A TNF 23840908 2818818 Positive_regulation IL1A TNF 23840908 2818822 Positive_regulation IL1A TNF 23843682 1754004 Positive_regulation IL1A TNF 23924945 1109764 Positive_regulation IL1A TNF 23940760 2832268 Positive_regulation IL1A TNF 23940760 2832269 Positive_regulation IL1A TNF 23940760 2832270 Positive_regulation IL1A TNF 23940760 2832271 Positive_regulation IL1A TNF 23940760 2832291 Positive_regulation IL1A TNF 23940760 2832312 Positive_regulation IL1A TNF 23940775 2832354 Positive_regulation IL1A TNF 23962134 1050797 Positive_regulation IL1A TNF 23970974 1154563 Positive_regulation IL1A TNF 23971042 183223 Positive_regulation IL1A TNF 23986795 2220455 Positive_regulation IL1A TNF 24058610 2848244 Positive_regulation IL1A TNF 24073392 1078394 Positive_regulation IL1A TNF 24073392 1078396 Positive_regulation IL1A TNF 24137421 2165709 Positive_regulation IL1A TNF 24141610 453548 Positive_regulation IL1A TNF 24141950 1991013 Positive_regulation IL1A TNF 24156755 380455 Positive_regulation IL1A TNF 24171032 638788 Positive_regulation IL1A TNF 24175110 1053776 Positive_regulation IL1A TNF 24192345 295263 Positive_regulation IL1A TNF 24223987 2877535 Positive_regulation IL1A TNF 24228622 359357 Positive_regulation IL1A TNF 24228622 359366 Positive_regulation IL1A TNF 24283517 130104 Positive_regulation IL1A TNF 24283517 130105 Positive_regulation IL1A TNF 24283517 130106 Positive_regulation IL1A TNF 24283517 130107 Positive_regulation IL1A TNF 24283517 130113 Positive_regulation IL1A TNF 24283517 130127 Positive_regulation IL1A TNF 24314293 314637 Positive_regulation IL1A TNF 24330807 1667426 Positive_regulation IL1A TNF 24330827 1667474 Positive_regulation IL1A TNF 24339952 2894384 Positive_regulation IL1A TNF 24339952 2894385 Positive_regulation IL1A TNF 24348193 3155620 Positive_regulation IL1A TNF 24379884 1148600 Positive_regulation IL1A TNF 24397846 139164 Positive_regulation IL1A TNF 24453977 3066012 Positive_regulation IL1A TNF 24471106 3077386 Positive_regulation IL1A TNF 24495480 131696 Positive_regulation IL1A TNF 2450953 1574923 Positive_regulation IL1A TNF 24594641 2929966 Positive_regulation IL1A TNF 24595131 2930795 Positive_regulation IL1A TNF 24595131 2930796 Positive_regulation IL1A TNF 24595131 2930820 Positive_regulation IL1A TNF 24648814 1712229 Positive_regulation IL1A TNF 24669186 742964 Positive_regulation IL1A TNF 24762050 132322 Positive_regulation IL1A TNF 24788542 2959141 Positive_regulation IL1A TNF 24819928 2968859 Positive_regulation IL1A TNF 24830946 2970371 Positive_regulation IL1A TNF 24864134 1758814 Positive_regulation IL1A TNF 24864134 1758815 Positive_regulation IL1A TNF 24864134 1758821 Positive_regulation IL1A TNF 24864134 1758823 Positive_regulation IL1A TNF 24864134 1758827 Positive_regulation IL1A TNF 24864134 1758831 Positive_regulation IL1A TNF 24864134 1758833 Positive_regulation IL1A TNF 24864134 1758835 Positive_regulation IL1A TNF 24864134 1758836 Positive_regulation IL1A TNF 24885494 396633 Positive_regulation IL1A TNF 24920275 2213776 Positive_regulation IL1A TNF 24971321 193311 Positive_regulation IL1A TNF 25057505 1622518 Positive_regulation IL1A TNF 25071589 965546 Positive_regulation IL1A TNF 25093709 34313 Positive_regulation IL1A TNF 25104881 1760304 Positive_regulation IL1A TNF 25120672 2169283 Positive_regulation IL1A TNF 25143751 645498 Positive_regulation IL1A TNF 25248126 3009300 Positive_regulation IL1A TNF 25289073 845243 Positive_regulation IL1A TNF 25501329 1135633 Positive_regulation IL1A TNF 25506235 1629230 Positive_regulation IL1A TNF 25544854 827550 Positive_regulation IL1A TNF 25552899 744128 Positive_regulation IL1A TNF 25614712 1763570 Positive_regulation IL1A TNF 2647895 1577614 Positive_regulation IL1A TNF 2950198 1579172 Positive_regulation IL1A TNF 3011946 1579628 Positive_regulation IL1A TNF 3351436 1581145 Positive_regulation IL1A TNF 3491174 1583098 Positive_regulation IL1A TNF 3491174 1583110 Positive_regulation IL1A TNF 3494807 1583288 Positive_regulation IL1A TNF 3494807 1583289 Positive_regulation IL1A TNF 3494807 1583291 Positive_regulation IL1A TNF 3494807 1583336 Positive_regulation IL1A TNF 3598461 1583533 Positive_regulation IL1A TNF 3598461 1583544 Positive_regulation IL1A TNF 3598461 1583545 Positive_regulation IL1A TNF 7530759 1589784 Positive_regulation IL1A TNF 9314541 1463953 Positive_regulation IL1A TNF PMC2833524 134184 Positive_regulation IL1A TNF PMC2911611 1053886 Positive_regulation IL1A TNFSF10 22194670 3152400 Positive_regulation IL1A TNFSF10 PMC2833857 134394 Positive_regulation IL1A WNT7A 23965253 129064 Positive_regulation IL1A WNT7A 24479426 131632 Positive_regulation IL1B ACHE 23671623 2792250 Positive_regulation IL1B ADAM17 22792188 2661287 Positive_regulation IL1B ADCY1 16571116 1624896 Positive_regulation IL1B ADCY10 16571116 1624895 Positive_regulation IL1B ADCY2 16571116 1624897 Positive_regulation IL1B ADCY3 16571116 1624898 Positive_regulation IL1B ADCY4 16571116 1624899 Positive_regulation IL1B ADCY5 16571116 1624900 Positive_regulation IL1B ADCY6 16571116 1624901 Positive_regulation IL1B ADCY7 16571116 1624902 Positive_regulation IL1B ADCY8 16571116 1624903 Positive_regulation IL1B ADCY9 16571116 1624904 Positive_regulation IL1B AHSA1 21202091 2899 Positive_regulation IL1B AKT1 23867201 2183667 Positive_regulation IL1B AKT2 23867201 2183668 Positive_regulation IL1B AKT2 23867201 2183675 Positive_regulation IL1B AKT3 23867201 2183669 Positive_regulation IL1B BMP7 19011694 2400852 Positive_regulation IL1B BMP7 19011694 2400865 Positive_regulation IL1B CADM1 18472842 1742258 Positive_regulation IL1B CADM2 18472842 1742256 Positive_regulation IL1B CADM3 18472842 1742255 Positive_regulation IL1B CADM4 18472842 1742257 Positive_regulation IL1B CASP1 20380728 3098260 Positive_regulation IL1B CASP1 23049756 2699333 Positive_regulation IL1B CASP1 23970884 908641 Positive_regulation IL1B CASP1 23977202 2839225 Positive_regulation IL1B CASP1 24350678 410832 Positive_regulation IL1B CASP1 24427758 647390 Positive_regulation IL1B CASP1 24701565 188184 Positive_regulation IL1B CASP1 24972036 2985190 Positive_regulation IL1B CASP10 24972036 2985191 Positive_regulation IL1B CASP12 24972036 2985201 Positive_regulation IL1B CASP14 24972036 2985192 Positive_regulation IL1B CASP16 24972036 2985202 Positive_regulation IL1B CASP2 24972036 2985193 Positive_regulation IL1B CASP3 24972036 2985194 Positive_regulation IL1B CASP4 24972036 2985195 Positive_regulation IL1B CASP5 24972036 2985196 Positive_regulation IL1B CASP6 24972036 2985197 Positive_regulation IL1B CASP7 24972036 2985198 Positive_regulation IL1B CASP8 24972036 2985199 Positive_regulation IL1B CASP9 24972036 2985200 Positive_regulation IL1B CCL2 20305745 2214363 Positive_regulation IL1B CCL2 23717664 2798675 Positive_regulation IL1B CD14 17242961 810081 Positive_regulation IL1B CDK9 24009751 2841594 Positive_regulation IL1B CDKN2A 23520533 2769035 Positive_regulation IL1B CDKN2A 24572376 131950 Positive_regulation IL1B CFTR 16571116 1624894 Positive_regulation IL1B CSF1 19773616 736327 Positive_regulation IL1B CSF2 11132773 1737266 Positive_regulation IL1B CSF2 11132773 1737267 Positive_regulation IL1B CSF3 20388227 845613 Positive_regulation IL1B CSF3R 20388227 845614 Positive_regulation IL1B CXCL5 19954533 2232846 Positive_regulation IL1B EDN1 19954533 2232847 Positive_regulation IL1B EGFR 22792188 2661228 Positive_regulation IL1B EGFR 22792188 2661257 Positive_regulation IL1B EGFR 22792188 2661292 Positive_regulation IL1B ESX1 23649713 3158264 Positive_regulation IL1B FAS 10704145 1737019 Positive_regulation IL1B FAS 21120077 1046262 Positive_regulation IL1B GP2 23286246 2111807 Positive_regulation IL1B GP5 23286246 2111808 Positive_regulation IL1B GP6 23286246 2111806 Positive_regulation IL1B GP9 23286246 2111809 Positive_regulation IL1B HLA-A 16162034 2368497 Positive_regulation IL1B HSPA1A 24213112 499442 Positive_regulation IL1B HSPB1 24213112 499443 Positive_regulation IL1B HSPB11 24213112 499438 Positive_regulation IL1B HSPB2 24213112 499444 Positive_regulation IL1B HSPB3 24213112 499445 Positive_regulation IL1B HSPB6 24213112 499439 Positive_regulation IL1B HSPB7 24213112 499446 Positive_regulation IL1B HSPB8 24213112 499440 Positive_regulation IL1B HSPB9 24213112 499441 Positive_regulation IL1B ICAM1 25530684 1763481 Positive_regulation IL1B IFNB1 22039457 2565519 Positive_regulation IL1B IFNG 23293538 490861 Positive_regulation IL1B IFNG 24791137 1916890 Positive_regulation IL1B IGF1R 25344917 2206200 Positive_regulation IL1B IL10 22384122 2605978 Positive_regulation IL1B IL10 24465555 2910744 Positive_regulation IL1B IL10 PMC137244 660841 Positive_regulation IL1B IL11 22384122 2605979 Positive_regulation IL1B IL12A 23209897 97736 Positive_regulation IL1B IL12B 23164360 1231820 Positive_regulation IL1B IL12B 23209897 97737 Positive_regulation IL1B IL13 22384122 2605980 Positive_regulation IL1B IL15 22384122 2605981 Positive_regulation IL1B IL16 22384122 2605982 Positive_regulation IL1B IL17A 18591407 1551461 Positive_regulation IL1B IL17A 24221190 3126134 Positive_regulation IL1B IL17B 25152827 1083038 Positive_regulation IL1B IL17C 25152827 1083039 Positive_regulation IL1B IL18 21569399 1697258 Positive_regulation IL1B IL18 22384122 2605983 Positive_regulation IL1B IL18 23915129 359219 Positive_regulation IL1B IL19 22384122 2605984 Positive_regulation IL1B IL1A 22039457 2565520 Positive_regulation IL1B IL1A 23936458 2830986 Positive_regulation IL1B IL1A 24156755 380458 Positive_regulation IL1B IL1A 24618842 2933385 Positive_regulation IL1B IL1RN 25332697 88966 Positive_regulation IL1B IL2 22384122 2605985 Positive_regulation IL1B IL20 22384122 2605986 Positive_regulation IL1B IL21 22384122 2605987 Positive_regulation IL1B IL22 22384122 2605970 Positive_regulation IL1B IL23A 23164360 1231819 Positive_regulation IL1B IL23A 23209897 97735 Positive_regulation IL1B IL24 22384122 2605968 Positive_regulation IL1B IL25 22384122 2605969 Positive_regulation IL1B IL26 22384122 2605974 Positive_regulation IL1B IL26 23055831 2280417 Positive_regulation IL1B IL26 23055831 2280442 Positive_regulation IL1B IL27 22384122 2605975 Positive_regulation IL1B IL3 22384122 2605988 Positive_regulation IL1B IL31 22384122 2605976 Positive_regulation IL1B IL32 22384122 2605973 Positive_regulation IL1B IL33 22384122 2605972 Positive_regulation IL1B IL34 22384122 2605977 Positive_regulation IL1B IL37 22384122 2605971 Positive_regulation IL1B IL37 25375146 3070123 Positive_regulation IL1B IL4 22384122 2605989 Positive_regulation IL1B IL5 22384122 2605990 Positive_regulation IL1B IL6 17162354 630464 Positive_regulation IL1B IL6 22229105 1082426 Positive_regulation IL1B IL6 22384122 2605991 Positive_regulation IL1B IL6 23055831 2280447 Positive_regulation IL1B IL6 25346723 881269 Positive_regulation IL1B IL6 25530684 1763482 Positive_regulation IL1B IL6ST 24009751 2841595 Positive_regulation IL1B IL7 22384122 2605992 Positive_regulation IL1B IL8 22384122 2605993 Positive_regulation IL1B IL9 22384122 2605994 Positive_regulation IL1B INS 25377254 1884328 Positive_regulation IL1B JUN 19534809 253617 Positive_regulation IL1B JUN 23755222 2802105 Positive_regulation IL1B LGR4 24066001 1028801 Positive_regulation IL1B LGR5 24066001 1028803 Positive_regulation IL1B LGR6 24066001 1028802 Positive_regulation IL1B MAP3K7 20680494 1654490 Positive_regulation IL1B MIR146A 21694443 736913 Positive_regulation IL1B MMP1 20368140 1031119 Positive_regulation IL1B MMP12 22039457 2565521 Positive_regulation IL1B MMP13 19011694 2400871 Positive_regulation IL1B MMP14 20368140 1031120 Positive_regulation IL1B MMP3 20368140 1031121 Positive_regulation IL1B MMP9 12061424 1738145 Positive_regulation IL1B MMP9 20368140 1031122 Positive_regulation IL1B MMP9 22039457 2565522 Positive_regulation IL1B MMP9 22432004 2611481 Positive_regulation IL1B MMP9 23922722 2826287 Positive_regulation IL1B MSC 25562599 3037225 Positive_regulation IL1B MTX1 22984629 2689655 Positive_regulation IL1B MYD88 24400890 1482477 Positive_regulation IL1B MYLIP 19011694 2400853 Positive_regulation IL1B MYLIP 22536485 139673 Positive_regulation IL1B NAMPT 23198120 1615786 Positive_regulation IL1B NFKB1 12745547 1738448 Positive_regulation IL1B NFKB1 19534809 253618 Positive_regulation IL1B NFKB1 24009751 2841596 Positive_regulation IL1B NFKB1 24400890 1482478 Positive_regulation IL1B NFKB1 25344917 2206330 Positive_regulation IL1B NFKB1 25436109 1161793 Positive_regulation IL1B NFKB1 8642348 1596996 Positive_regulation IL1B NFKB1 9839693 1764068 Positive_regulation IL1B NLRC4 18811943 324180 Positive_regulation IL1B NLRP1 23970884 908640 Positive_regulation IL1B NLRP12 PMC3194427 2236097 Positive_regulation IL1B NLRP3 21740493 590606 Positive_regulation IL1B NLRP3 24701565 188185 Positive_regulation IL1B NOD1 20470404 402597 Positive_regulation IL1B NOD2 20949035 2477504 Positive_regulation IL1B NOS1 15040812 350451 Positive_regulation IL1B NOS1 18472818 1741819 Positive_regulation IL1B NOS2 11200365 1737604 Positive_regulation IL1B NOS2 18472818 1741820 Positive_regulation IL1B NOS2 7530759 1589919 Positive_regulation IL1B NOS3 18472818 1741821 Positive_regulation IL1B NOX4 24145286 2185080 Positive_regulation IL1B NPY 25221996 3007280 Positive_regulation IL1B P2RX4 18553155 3089814 Positive_regulation IL1B P2RX7 18404494 3089270 Positive_regulation IL1B P2RX7 24972036 2985203 Positive_regulation IL1B PI3 22737250 2655714 Positive_regulation IL1B PIK3CA 25344917 2206331 Positive_regulation IL1B PIK3R1 25344917 2206332 Positive_regulation IL1B PLA2G4A 18475724 1745697 Positive_regulation IL1B PLAA 10780577 3228156 Positive_regulation IL1B PLAU 24040137 2846001 Positive_regulation IL1B PPARA 19011694 2400854 Positive_regulation IL1B PQBP1 22355401 2597499 Positive_regulation IL1B PTEN 23867201 2183676 Positive_regulation IL1B PTGDS 19094210 112261 Positive_regulation IL1B PTGES 23437094 2755571 Positive_regulation IL1B PTGS1 9836494 1764018 Positive_regulation IL1B PTGS2 11200365 1737605 Positive_regulation IL1B PTGS2 11200365 1737606 Positive_regulation IL1B PTGS2 14627219 1049558 Positive_regulation IL1B PTGS2 15040812 350452 Positive_regulation IL1B PTGS2 24889212 34072 Positive_regulation IL1B PTGS2 9927229 1764211 Positive_regulation IL1B PTGS2 9927229 1764324 Positive_regulation IL1B REL 21283787 3051000 Positive_regulation IL1B RELA 12745547 1738449 Positive_regulation IL1B RELA 19534809 253619 Positive_regulation IL1B RELA 24009751 2841597 Positive_regulation IL1B RELA 24400890 1482479 Positive_regulation IL1B RELA 25344917 2206333 Positive_regulation IL1B RELA 25436109 1161794 Positive_regulation IL1B RELA 8642348 1596997 Positive_regulation IL1B RELA 9839693 1764069 Positive_regulation IL1B RNF19A 22605923 1914329 Positive_regulation IL1B SAA1 12857601 1738641 Positive_regulation IL1B SERPINE1 22220265 1764534 Positive_regulation IL1B SGCG 20419126 2447044 Positive_regulation IL1B SMAD7 21445336 2509450 Positive_regulation IL1B SMAD7 24791137 1916891 Positive_regulation IL1B SOD1 15512788 831032 Positive_regulation IL1B SOD1 22683550 30691 Positive_regulation IL1B SOD2 15512788 831033 Positive_regulation IL1B SOD2 24885568 365027 Positive_regulation IL1B SOD3 15512788 831034 Positive_regulation IL1B SPESP1 24330735 3210794 Positive_regulation IL1B SPI1 23936458 2831019 Positive_regulation IL1B SPI1 23936458 2831021 Positive_regulation IL1B STAT1 25024400 1637291 Positive_regulation IL1B STAT3 22558380 2625422 Positive_regulation IL1B STS 23970884 908639 Positive_regulation IL1B STS 23977202 2839227 Positive_regulation IL1B STS 24701565 188183 Positive_regulation IL1B SYK 21740493 590605 Positive_regulation IL1B TAS2R38 25562599 3037242 Positive_regulation IL1B TBCA 17196111 1896872 Positive_regulation IL1B TLR1 22286305 1962107 Positive_regulation IL1B TLR1 23936458 2830976 Positive_regulation IL1B TLR1 PMC3952087 2236170 Positive_regulation IL1B TLR10 22286305 1962115 Positive_regulation IL1B TLR10 23936458 2830984 Positive_regulation IL1B TLR10 PMC3952087 2236178 Positive_regulation IL1B TLR2 20948855 847206 Positive_regulation IL1B TLR2 20949035 2477503 Positive_regulation IL1B TLR2 22286305 1962108 Positive_regulation IL1B TLR2 23936458 2830977 Positive_regulation IL1B TLR2 24669209 685256 Positive_regulation IL1B TLR2 25076967 896478 Positive_regulation IL1B TLR2 PMC3952087 2236171 Positive_regulation IL1B TLR3 22286305 1962109 Positive_regulation IL1B TLR3 23936458 2830978 Positive_regulation IL1B TLR3 PMC3952087 2236172 Positive_regulation IL1B TLR4 22286305 1962110 Positive_regulation IL1B TLR4 23936458 2830979 Positive_regulation IL1B TLR4 23936458 2831023 Positive_regulation IL1B TLR4 24400890 1482476 Positive_regulation IL1B TLR4 24669209 685257 Positive_regulation IL1B TLR4 25182709 660749 Positive_regulation IL1B TLR4 PMC3952087 2236173 Positive_regulation IL1B TLR5 22286305 1962111 Positive_regulation IL1B TLR5 23936458 2830980 Positive_regulation IL1B TLR5 PMC3952087 2236174 Positive_regulation IL1B TLR6 22286305 1962116 Positive_regulation IL1B TLR6 23936458 2830985 Positive_regulation IL1B TLR6 PMC3952087 2236179 Positive_regulation IL1B TLR7 22286305 1962112 Positive_regulation IL1B TLR7 23936458 2830981 Positive_regulation IL1B TLR7 PMC3952087 2236175 Positive_regulation IL1B TLR8 22286305 1962113 Positive_regulation IL1B TLR8 23936458 2830982 Positive_regulation IL1B TLR8 PMC3952087 2236176 Positive_regulation IL1B TLR9 22286305 1962114 Positive_regulation IL1B TLR9 23936458 2830983 Positive_regulation IL1B TLR9 PMC3952087 2236177 Positive_regulation IL1B TM4SF4 25344917 2206310 Positive_regulation IL1B TNF 19198593 1952248 Positive_regulation IL1B TNF 21569399 1697251 Positive_regulation IL1B TNF 21569399 1697257 Positive_regulation IL1B TNF 22235301 2585774 Positive_regulation IL1B TNF 23055831 2280446 Positive_regulation IL1B TNF 24098382 2856022 Positive_regulation IL1B TNF 24156755 380457 Positive_regulation IL1B TNF 24628956 347062 Positive_regulation IL1B TNF 25165721 198427 Positive_regulation IL1B TNFSF11 21708014 123052 Positive_regulation IL1B TYR 22792188 2661446 Positive_regulation IL1B VCAM1 12537603 3103822 Positive_regulation IL1B VCAM1 18472842 1742254 Positive_regulation IL1B VDR 23762029 3062319 Positive_regulation IL1B VEGFC 23717664 2798676 Positive_regulation IL1R1 IL1B 23717664 2798664 Positive_regulation IL1R1 IL1B 23717664 2798665 Positive_regulation IL1R1 IL1B 23717664 2798682 Positive_regulation IL1R1 IL1B 25436109 1161795 Positive_regulation IL1R1 IL1R2 23847618 908119 Positive_regulation IL1R1 TLR7 18268042 1549428 Positive_regulation IL1R1 TLR7 23760366 2211842 Positive_regulation IL1R1 TLR7 24752299 1575939 Positive_regulation IL1R1 TNF 19435506 113226 Positive_regulation IL1R1 TNF 23251037 1751083 Positive_regulation IL1R2 IL10 22642771 1662494 Positive_regulation IL1R2 IL11 22642771 1662495 Positive_regulation IL1R2 IL13 18475738 1745918 Positive_regulation IL1R2 IL13 22642771 1662496 Positive_regulation IL1R2 IL15 22642771 1662497 Positive_regulation IL1R2 IL16 22642771 1662498 Positive_regulation IL1R2 IL18 22642771 1662499 Positive_regulation IL1R2 IL19 22642771 1662500 Positive_regulation IL1R2 IL1A 25071776 913367 Positive_regulation IL1R2 IL1B 23717664 2798666 Positive_regulation IL1R2 IL1B 23717664 2798667 Positive_regulation IL1R2 IL2 22642771 1662501 Positive_regulation IL1R2 IL20 22642771 1662502 Positive_regulation IL1R2 IL21 22642771 1662503 Positive_regulation IL1R2 IL22 22642771 1662486 Positive_regulation IL1R2 IL24 22642771 1662484 Positive_regulation IL1R2 IL25 22642771 1662485 Positive_regulation IL1R2 IL26 22642771 1662490 Positive_regulation IL1R2 IL27 22642771 1662491 Positive_regulation IL1R2 IL3 22642771 1662504 Positive_regulation IL1R2 IL31 22642771 1662492 Positive_regulation IL1R2 IL32 22642771 1662489 Positive_regulation IL1R2 IL33 22642771 1662488 Positive_regulation IL1R2 IL34 22642771 1662493 Positive_regulation IL1R2 IL37 22642771 1662487 Positive_regulation IL1R2 IL4 19401759 2415567 Positive_regulation IL1R2 IL4 22642771 1662505 Positive_regulation IL1R2 IL5 22642771 1662506 Positive_regulation IL1R2 IL6 22642771 1662507 Positive_regulation IL1R2 IL7 22642771 1662508 Positive_regulation IL1R2 IL8 22642771 1662509 Positive_regulation IL1R2 IL9 22642771 1662510 Positive_regulation IL1R2 TCL1A 22405131 471317 Positive_regulation IL1R2 TCL1A 22405131 471324 Positive_regulation IL1RAP IL1B 25436109 1161796 Positive_regulation IL1RL1 CYP24A1 23497279 268037 Positive_regulation IL1RL1 IL33 24933019 2980537 Positive_regulation IL1RL1 IL4 24832045 176602 Positive_regulation IL1RL1 STAT6 24832045 176601 Positive_regulation IL1RN ANGPT1 24563688 2923995 Positive_regulation IL1RN ANGPT1 24563688 2923996 Positive_regulation IL1RN ANGPT1 24563688 2923997 Positive_regulation IL1RN AXIN2 10496353 415382 Positive_regulation IL1RN IL1B 15203568 1739688 Positive_regulation IL1RN IL1B 15203568 1739696 Positive_regulation IL1RN IL1B 23049596 636988 Positive_regulation IL1RN IL1B 23717664 2798668 Positive_regulation IL1RN IL1B 23717664 2798669 Positive_regulation IL1RN LAMB3 23024638 925224 Positive_regulation IL1RN MAP2K6 24855454 1627899 Positive_regulation IL1RN TLR7 25071732 927029 Positive_regulation IL1RN TLR7 25071732 927108 Positive_regulation IL1RN TNF 1386877 1528870 Positive_regulation IL1RN TNF 15142263 101160 Positive_regulation IL1RN TNF 19435506 113227 Positive_regulation IL1RN TNF 20798882 1670090 Positive_regulation IL1RN TNF 22095690 1033507 Positive_regulation IL1RN TNF 23861894 2820588 Positive_regulation IL1RN TNF 23908975 649296 Positive_regulation IL1RN TNF 25229476 3008039 Positive_regulation IL2 ARSA 18475590 1744476 Positive_regulation IL2 CAPN8 24961530 452856 Positive_regulation IL2 CD14 25025695 2989344 Positive_regulation IL2 EPHB2 15833106 3104955 Positive_regulation IL2 EPHB2 16172258 1537835 Positive_regulation IL2 EPHB2 19025606 1646436 Positive_regulation IL2 EPHB2 22719740 901958 Positive_regulation IL2 EPHB2 23227982 534214 Positive_regulation IL2 EPHB2 23874109 2121511 Positive_regulation IL2 EPHB2 8642312 1596846 Positive_regulation IL2 EPHB2 9362525 1601981 Positive_regulation IL2 EPHB2 PMC3236909 3125403 Positive_regulation IL2 F2R 21464892 2510298 Positive_regulation IL2 FAS 11104808 1518137 Positive_regulation IL2 FAS 12610520 422251 Positive_regulation IL2 FOXO1 22532866 2621810 Positive_regulation IL2 IFI27 15059264 100902 Positive_regulation IL2 ITGAL 14676297 1530013 Positive_regulation IL2 ITGAL 2569026 1577443 Positive_regulation IL2 ITGB2 1717633 1543733 Positive_regulation IL2 ITGB2 23864893 821535 Positive_regulation IL2 ITGB2 23864893 821536 Positive_regulation IL2 ITGB2 23864893 821537 Positive_regulation IL2 ITGB2 2569026 1577447 Positive_regulation IL2 ITGB2 7519245 1589407 Positive_regulation IL2 JAG1 2965740 1579438 Positive_regulation IL2 LBP 19672466 1670831 Positive_regulation IL2 LBP 19672466 1670833 Positive_regulation IL2 LBP 20046845 1670890 Positive_regulation IL2 LBP 20046845 1670892 Positive_regulation IL2 LBP 25025695 2989345 Positive_regulation IL2 LBP 25552899 744112 Positive_regulation IL2 MAP2K6 10544198 1512867 Positive_regulation IL2 NEDD9 PMC2833882 134411 Positive_regulation IL2 NEDD9 PMC2833901 134426 Positive_regulation IL2 PDE4B 23451206 2758374 Positive_regulation IL2 PDE4B 23451206 2758376 Positive_regulation IL2 STAT4 20104254 1910516 Positive_regulation IL2 TLR7 11686880 3103226 Positive_regulation IL2 TLR7 20546588 1036364 Positive_regulation IL2 TLR7 22984435 2688581 Positive_regulation IL2 TLR7 23800014 1232257 Positive_regulation IL2 TNF 10732751 416380 Positive_regulation IL2 TNF 1311016 1528336 Positive_regulation IL2 TNF 1328463 1528415 Positive_regulation IL2 TNF 1328463 1528417 Positive_regulation IL2 TNF 1402671 1528906 Positive_regulation IL2 TNF 1586593 426058 Positive_regulation IL2 TNF 1643416 702480 Positive_regulation IL2 TNF 1692079 1542191 Positive_regulation IL2 TNF 1717633 1543728 Positive_regulation IL2 TNF 1733448 428967 Positive_regulation IL2 TNF 18475440 1743775 Positive_regulation IL2 TNF 18475462 1743837 Positive_regulation IL2 TNF 1911209 431578 Positive_regulation IL2 TNF 19434244 646261 Positive_regulation IL2 TNF 19742190 1048185 Positive_regulation IL2 TNF 19936089 981563 Positive_regulation IL2 TNF 2007858 1557305 Positive_regulation IL2 TNF 2022925 1557584 Positive_regulation IL2 TNF 2022925 1557612 Positive_regulation IL2 TNF 2039696 434766 Positive_regulation IL2 TNF 2056282 1558508 Positive_regulation IL2 TNF 20808962 2473143 Positive_regulation IL2 TNF 21159177 354207 Positive_regulation IL2 TNF 2170559 1564092 Positive_regulation IL2 TNF 2170559 1564099 Positive_regulation IL2 TNF 21829352 3052740 Positive_regulation IL2 TNF 2183871 437513 Positive_regulation IL2 TNF 2183871 437585 Positive_regulation IL2 TNF 2183871 437586 Positive_regulation IL2 TNF 2183871 437622 Positive_regulation IL2 TNF 2183871 437623 Positive_regulation IL2 TNF 22523581 2620404 Positive_regulation IL2 TNF 22523581 2620405 Positive_regulation IL2 TNF 2258696 1568200 Positive_regulation IL2 TNF 23704321 3126200 Positive_regulation IL2 TNF 2373990 1572275 Positive_regulation IL2 TNF 23801992 907932 Positive_regulation IL2 TNF 23903060 828797 Positive_regulation IL2 TNF 2406363 1573706 Positive_regulation IL2 TNF 24587225 2929138 Positive_regulation IL2 TNF 2499653 1576995 Positive_regulation IL2 TNF 25090613 2995130 Positive_regulation IL2 TNF 2642531 1577572 Positive_regulation IL2 TNF 2659724 1577661 Positive_regulation IL2 TNF 2769183 1577886 Positive_regulation IL2 TNF 2785398 442928 Positive_regulation IL2 TNF 2785398 442938 Positive_regulation IL2 TNF 2803928 443149 Positive_regulation IL2 TNF 2833558 1578540 Positive_regulation IL2 TNF 2903211 1578642 Positive_regulation IL2 TNF 3049617 1425482 Positive_regulation IL2 TNF 3049617 1425483 Positive_regulation IL2 TNF 3049617 1425590 Positive_regulation IL2 TNF 3049617 1425591 Positive_regulation IL2 TNF 3110354 1580059 Positive_regulation IL2 TNF 3137305 1580372 Positive_regulation IL2 TNF 3143799 1580427 Positive_regulation IL2 TNF 3290384 1580793 Positive_regulation IL2 TNF 3309124 1580912 Positive_regulation IL2 TNF 3309124 1580966 Positive_regulation IL2 TNF 3316469 1581026 Positive_regulation IL2 TNF 3411293 1581192 Positive_regulation IL2 TNF 3435706 443507 Positive_regulation IL2 TNF 3491174 1583099 Positive_regulation IL2 TNF 3494807 1583267 Positive_regulation IL2 TNF 3494807 1583268 Positive_regulation IL2 TNF 3494807 1583337 Positive_regulation IL2 TNF 3498791 1583388 Positive_regulation IL2 TNF 3498791 1583389 Positive_regulation IL2 TNF 3572302 1583475 Positive_regulation IL2 TNF 3598461 1583534 Positive_regulation IL2 TNF 3598461 1583568 Positive_regulation IL2 TNF 3819645 1583710 Positive_regulation IL2 TNF 8064232 1593940 Positive_regulation IL2 TNF 8426121 1595202 Positive_regulation IL2 TNF 8478614 1595552 Positive_regulation IL2 TNF 9652754 447277 Positive_regulation IL2 TNF PMC2188223 1605401 Positive_regulation IL2 TNF PMC3301785 660983 Positive_regulation IL20 CD14 25025695 2989346 Positive_regulation IL20 LBP 25025695 2989347 Positive_regulation IL20 TLR7 11686880 3103236 Positive_regulation IL20 TNF 1311016 1528337 Positive_regulation IL20 TNF 1586593 426059 Positive_regulation IL20 TNF 1643416 702481 Positive_regulation IL20 TNF 1692079 1542192 Positive_regulation IL20 TNF 1717633 1543734 Positive_regulation IL20 TNF 18475440 1743776 Positive_regulation IL20 TNF 1911209 431579 Positive_regulation IL20 TNF 19742190 1048186 Positive_regulation IL20 TNF 19936089 981565 Positive_regulation IL20 TNF 2007858 1557306 Positive_regulation IL20 TNF 2022925 1557585 Positive_regulation IL20 TNF 2022925 1557613 Positive_regulation IL20 TNF 2039696 434767 Positive_regulation IL20 TNF 20808962 2473144 Positive_regulation IL20 TNF 21829352 3052745 Positive_regulation IL20 TNF 2183871 437514 Positive_regulation IL20 TNF 2183871 437587 Positive_regulation IL20 TNF 2183871 437588 Positive_regulation IL20 TNF 2183871 437624 Positive_regulation IL20 TNF 2258696 1568201 Positive_regulation IL20 TNF 2373990 1572276 Positive_regulation IL20 TNF 2406363 1573707 Positive_regulation IL20 TNF 2499653 1576996 Positive_regulation IL20 TNF 2642531 1577573 Positive_regulation IL20 TNF 2659724 1577662 Positive_regulation IL20 TNF 2769183 1577887 Positive_regulation IL20 TNF 2785398 442929 Positive_regulation IL20 TNF 2803928 443150 Positive_regulation IL20 TNF 2833558 1578541 Positive_regulation IL20 TNF 3049617 1425484 Positive_regulation IL20 TNF 3049617 1425485 Positive_regulation IL20 TNF 3049617 1425592 Positive_regulation IL20 TNF 3049617 1425593 Positive_regulation IL20 TNF 3110354 1580060 Positive_regulation IL20 TNF 3137305 1580373 Positive_regulation IL20 TNF 3143799 1580428 Positive_regulation IL20 TNF 3290384 1580794 Positive_regulation IL20 TNF 3309124 1580913 Positive_regulation IL20 TNF 3309124 1580967 Positive_regulation IL20 TNF 3316469 1581027 Positive_regulation IL20 TNF 3411293 1581193 Positive_regulation IL20 TNF 3435706 443508 Positive_regulation IL20 TNF 3491174 1583100 Positive_regulation IL20 TNF 3494807 1583269 Positive_regulation IL20 TNF 3494807 1583270 Positive_regulation IL20 TNF 3494807 1583338 Positive_regulation IL20 TNF 3572302 1583476 Positive_regulation IL20 TNF 3598461 1583535 Positive_regulation IL20 TNF 3598461 1583569 Positive_regulation IL20 TNF 3819645 1583711 Positive_regulation IL20 TNF 8426121 1595203 Positive_regulation IL20 TNF 8478614 1595553 Positive_regulation IL20 TNF PMC2188223 1605402 Positive_regulation IL21 CD14 25025695 2989348 Positive_regulation IL21 EPHB2 23193414 1156319 Positive_regulation IL21 LBP 25025695 2989349 Positive_regulation IL21 NT5E 24664100 2938108 Positive_regulation IL21 TLR7 11686880 3103246 Positive_regulation IL21 TLR7 25251568 3010163 Positive_regulation IL21 TNF 1311016 1528338 Positive_regulation IL21 TNF 1586593 426060 Positive_regulation IL21 TNF 1643416 702482 Positive_regulation IL21 TNF 1692079 1542193 Positive_regulation IL21 TNF 1717633 1543735 Positive_regulation IL21 TNF 18475440 1743777 Positive_regulation IL21 TNF 1911209 431580 Positive_regulation IL21 TNF 19742190 1048187 Positive_regulation IL21 TNF 19936089 981567 Positive_regulation IL21 TNF 2007858 1557307 Positive_regulation IL21 TNF 2022925 1557586 Positive_regulation IL21 TNF 2022925 1557614 Positive_regulation IL21 TNF 2039696 434768 Positive_regulation IL21 TNF 20808962 2473145 Positive_regulation IL21 TNF 21829352 3052750 Positive_regulation IL21 TNF 2183871 437515 Positive_regulation IL21 TNF 2183871 437589 Positive_regulation IL21 TNF 2183871 437590 Positive_regulation IL21 TNF 2183871 437625 Positive_regulation IL21 TNF 2258696 1568202 Positive_regulation IL21 TNF 2373990 1572277 Positive_regulation IL21 TNF 2406363 1573708 Positive_regulation IL21 TNF 2499653 1576997 Positive_regulation IL21 TNF 25251568 3010170 Positive_regulation IL21 TNF 2642531 1577574 Positive_regulation IL21 TNF 2659724 1577663 Positive_regulation IL21 TNF 2769183 1577888 Positive_regulation IL21 TNF 2785398 442930 Positive_regulation IL21 TNF 2803928 443151 Positive_regulation IL21 TNF 2833558 1578542 Positive_regulation IL21 TNF 3049617 1425486 Positive_regulation IL21 TNF 3049617 1425487 Positive_regulation IL21 TNF 3049617 1425594 Positive_regulation IL21 TNF 3049617 1425595 Positive_regulation IL21 TNF 3110354 1580061 Positive_regulation IL21 TNF 3137305 1580374 Positive_regulation IL21 TNF 3143799 1580429 Positive_regulation IL21 TNF 3290384 1580795 Positive_regulation IL21 TNF 3309124 1580914 Positive_regulation IL21 TNF 3309124 1580968 Positive_regulation IL21 TNF 3316469 1581028 Positive_regulation IL21 TNF 3411293 1581194 Positive_regulation IL21 TNF 3435706 443509 Positive_regulation IL21 TNF 3491174 1583101 Positive_regulation IL21 TNF 3494807 1583271 Positive_regulation IL21 TNF 3494807 1583272 Positive_regulation IL21 TNF 3494807 1583339 Positive_regulation IL21 TNF 3572302 1583477 Positive_regulation IL21 TNF 3598461 1583536 Positive_regulation IL21 TNF 3598461 1583570 Positive_regulation IL21 TNF 3819645 1583712 Positive_regulation IL21 TNF 8426121 1595204 Positive_regulation IL21 TNF 8478614 1595554 Positive_regulation IL21 TNF PMC2188223 1605403 Positive_regulation IL22 CD14 25025695 2989286 Positive_regulation IL22 EPHB2 21897855 2549863 Positive_regulation IL22 FOXO1 21825017 1564532 Positive_regulation IL22 FOXO1 21825017 1564582 Positive_regulation IL22 LBP 18389070 631100 Positive_regulation IL22 LBP 25025695 2989287 Positive_regulation IL22 RORC 21825017 1564531 Positive_regulation IL22 RORC 23798999 2806662 Positive_regulation IL22 S100A7 23197904 88214 Positive_regulation IL22 S100A7 25010647 2987983 Positive_regulation IL22 S100A7 25140116 1761015 Positive_regulation IL22 TLR7 11686880 3103049 Positive_regulation IL22 TLR7 24358364 2899732 Positive_regulation IL22 TLR7 24740301 2954615 Positive_regulation IL22 TLR7 24740301 2954631 Positive_regulation IL22 TNF 1311016 1528321 Positive_regulation IL22 TNF 1586593 426041 Positive_regulation IL22 TNF 1643416 702465 Positive_regulation IL22 TNF 1692079 1542176 Positive_regulation IL22 TNF 16982811 1542467 Positive_regulation IL22 TNF 1717633 1543708 Positive_regulation IL22 TNF 18475440 1743760 Positive_regulation IL22 TNF 1911209 431562 Positive_regulation IL22 TNF 19742190 1048170 Positive_regulation IL22 TNF 19936089 981531 Positive_regulation IL22 TNF 2007858 1557289 Positive_regulation IL22 TNF 2022925 1557569 Positive_regulation IL22 TNF 2022925 1557597 Positive_regulation IL22 TNF 2039696 434751 Positive_regulation IL22 TNF 20808962 2473128 Positive_regulation IL22 TNF 21829352 3052622 Positive_regulation IL22 TNF 2183871 437496 Positive_regulation IL22 TNF 2183871 437555 Positive_regulation IL22 TNF 2183871 437556 Positive_regulation IL22 TNF 2183871 437607 Positive_regulation IL22 TNF 2258696 1568185 Positive_regulation IL22 TNF 23197904 88222 Positive_regulation IL22 TNF 2373990 1572260 Positive_regulation IL22 TNF 2406363 1573691 Positive_regulation IL22 TNF 24465207 3066055 Positive_regulation IL22 TNF 24623532 1050582 Positive_regulation IL22 TNF 2499653 1576980 Positive_regulation IL22 TNF 2642531 1577557 Positive_regulation IL22 TNF 2659724 1577646 Positive_regulation IL22 TNF 2769183 1577871 Positive_regulation IL22 TNF 2785398 442913 Positive_regulation IL22 TNF 2803928 443134 Positive_regulation IL22 TNF 2833558 1578525 Positive_regulation IL22 TNF 3049617 1425452 Positive_regulation IL22 TNF 3049617 1425453 Positive_regulation IL22 TNF 3049617 1425560 Positive_regulation IL22 TNF 3049617 1425561 Positive_regulation IL22 TNF 3110354 1580044 Positive_regulation IL22 TNF 3137305 1580357 Positive_regulation IL22 TNF 3143799 1580412 Positive_regulation IL22 TNF 3290384 1580778 Positive_regulation IL22 TNF 3309124 1580896 Positive_regulation IL22 TNF 3309124 1580951 Positive_regulation IL22 TNF 3316469 1581011 Positive_regulation IL22 TNF 3411293 1581177 Positive_regulation IL22 TNF 3435706 443492 Positive_regulation IL22 TNF 3491174 1583082 Positive_regulation IL22 TNF 3494807 1583237 Positive_regulation IL22 TNF 3494807 1583238 Positive_regulation IL22 TNF 3494807 1583321 Positive_regulation IL22 TNF 3572302 1583460 Positive_regulation IL22 TNF 3598461 1583518 Positive_regulation IL22 TNF 3598461 1583553 Positive_regulation IL22 TNF 3819645 1583695 Positive_regulation IL22 TNF 8426121 1595187 Positive_regulation IL22 TNF 8478614 1595537 Positive_regulation IL22 TNF PMC2188223 1605386 Positive_regulation IL23A CCL17 22737174 636381 Positive_regulation IL23A EPHB2 23901045 1065484 Positive_regulation IL23A EPHB2 25593648 207047 Positive_regulation IL23A FAS 19390568 487394 Positive_regulation IL23A IL1B 23209897 97724 Positive_regulation IL23A MAP2K6 23901045 1065490 Positive_regulation IL23A RORC 25566265 921699 Positive_regulation IL23A STAT4 21635716 122595 Positive_regulation IL23A STAT4 23469228 2763558 Positive_regulation IL23A STAT4 23469228 2763585 Positive_regulation IL23A STAT4 24600449 911321 Positive_regulation IL23A TLR7 17786191 2377934 Positive_regulation IL23A TLR7 18490488 1551168 Positive_regulation IL23A TLR7 18762568 1551861 Positive_regulation IL23A TLR7 18779348 1551917 Positive_regulation IL23A TLR7 21188221 1081673 Positive_regulation IL23A TLR7 22164330 97555 Positive_regulation IL23A TLR7 22417709 125063 Positive_regulation IL23A TLR7 23382974 2747363 Positive_regulation IL23A TLR7 23755218 2801963 Positive_regulation IL23A TLR7 23755218 2801964 Positive_regulation IL23A TLR7 23755218 2802078 Positive_regulation IL23A TLR7 23940256 1573336 Positive_regulation IL23A TLR7 23967307 2835770 Positive_regulation IL23A TLR7 23967307 2836054 Positive_regulation IL23A TLR7 23967307 2836055 Positive_regulation IL23A TLR7 23967307 2836175 Positive_regulation IL23A TLR7 24386404 2903863 Positive_regulation IL23A TLR7 24802102 2961885 Positive_regulation IL23A TNF 17306038 107818 Positive_regulation IL23A TNF 19815670 3126154 Positive_regulation IL23A TNF 21881590 1630494 Positive_regulation IL23A TNF 21881590 1630495 Positive_regulation IL23A TNF 21881590 1630505 Positive_regulation IL23A TNF 23316190 905572 Positive_regulation IL23A TNF 24023721 2843395 Positive_regulation IL23A TNF 24614867 2933157 Positive_regulation IL23A TNF 25105894 2996096 Positive_regulation IL23A TNF 25384035 3024621 Positive_regulation IL23R FOXO1 23467085 1990281 Positive_regulation IL23R RORC 24586521 2925286 Positive_regulation IL23R RORC 24611151 588854 Positive_regulation IL24 CD14 25025695 2989280 Positive_regulation IL24 FAS 17274815 1846150 Positive_regulation IL24 LBP 25025695 2989281 Positive_regulation IL24 MMP7 24270662 1632367 Positive_regulation IL24 TLR7 11686880 3103029 Positive_regulation IL24 TNF 1311016 1528319 Positive_regulation IL24 TNF 1586593 426011 Positive_regulation IL24 TNF 1643416 702436 Positive_regulation IL24 TNF 1692079 1542147 Positive_regulation IL24 TNF 1717633 1543679 Positive_regulation IL24 TNF 18475440 1743731 Positive_regulation IL24 TNF 1911209 431532 Positive_regulation IL24 TNF 19742190 1048168 Positive_regulation IL24 TNF 19936089 981527 Positive_regulation IL24 TNF 2007858 1557259 Positive_regulation IL24 TNF 2022925 1557540 Positive_regulation IL24 TNF 2022925 1557595 Positive_regulation IL24 TNF 2039696 434722 Positive_regulation IL24 TNF 20808962 2473126 Positive_regulation IL24 TNF 21829352 3052582 Positive_regulation IL24 TNF 2183871 437465 Positive_regulation IL24 TNF 2183871 437523 Positive_regulation IL24 TNF 2183871 437524 Positive_regulation IL24 TNF 2183871 437605 Positive_regulation IL24 TNF 2258696 1568156 Positive_regulation IL24 TNF 2373990 1572231 Positive_regulation IL24 TNF 2406363 1573662 Positive_regulation IL24 TNF 24949467 192780 Positive_regulation IL24 TNF 2499653 1576951 Positive_regulation IL24 TNF 2642531 1577528 Positive_regulation IL24 TNF 2659724 1577617 Positive_regulation IL24 TNF 2769183 1577842 Positive_regulation IL24 TNF 2785398 442884 Positive_regulation IL24 TNF 2803928 443132 Positive_regulation IL24 TNF 2833558 1578496 Positive_regulation IL24 TNF 3049617 1425420 Positive_regulation IL24 TNF 3049617 1425421 Positive_regulation IL24 TNF 3049617 1425422 Positive_regulation IL24 TNF 3049617 1425502 Positive_regulation IL24 TNF 3049617 1425503 Positive_regulation IL24 TNF 3110354 1580015 Positive_regulation IL24 TNF 3137305 1580328 Positive_regulation IL24 TNF 3143799 1580383 Positive_regulation IL24 TNF 3290384 1580749 Positive_regulation IL24 TNF 3309124 1580867 Positive_regulation IL24 TNF 3309124 1580922 Positive_regulation IL24 TNF 3316469 1580982 Positive_regulation IL24 TNF 3411293 1581148 Positive_regulation IL24 TNF 3435706 443463 Positive_regulation IL24 TNF 3491174 1583053 Positive_regulation IL24 TNF 3494807 1583179 Positive_regulation IL24 TNF 3494807 1583180 Positive_regulation IL24 TNF 3494807 1583292 Positive_regulation IL24 TNF 3572302 1583431 Positive_regulation IL24 TNF 3598461 1583489 Positive_regulation IL24 TNF 3598461 1583551 Positive_regulation IL24 TNF 3819645 1583666 Positive_regulation IL24 TNF 8426121 1595158 Positive_regulation IL24 TNF 8478614 1595508 Positive_regulation IL24 TNF PMC2188223 1605357 Positive_regulation IL25 CD14 25025695 2989284 Positive_regulation IL25 LBP 25025695 2989285 Positive_regulation IL25 TLR7 11686880 3103039 Positive_regulation IL25 TNF 1311016 1528320 Positive_regulation IL25 TNF 1586593 426040 Positive_regulation IL25 TNF 1643416 702464 Positive_regulation IL25 TNF 1692079 1542175 Positive_regulation IL25 TNF 1717633 1543707 Positive_regulation IL25 TNF 18475440 1743759 Positive_regulation IL25 TNF 1911209 431561 Positive_regulation IL25 TNF 19742190 1048169 Positive_regulation IL25 TNF 19936089 981529 Positive_regulation IL25 TNF 2007858 1557288 Positive_regulation IL25 TNF 2022925 1557568 Positive_regulation IL25 TNF 2022925 1557596 Positive_regulation IL25 TNF 2039696 434750 Positive_regulation IL25 TNF 20808962 2473127 Positive_regulation IL25 TNF 21829352 3052617 Positive_regulation IL25 TNF 2183871 437495 Positive_regulation IL25 TNF 2183871 437553 Positive_regulation IL25 TNF 2183871 437554 Positive_regulation IL25 TNF 2183871 437606 Positive_regulation IL25 TNF 2258696 1568184 Positive_regulation IL25 TNF 2373990 1572259 Positive_regulation IL25 TNF 2406363 1573690 Positive_regulation IL25 TNF 2499653 1576979 Positive_regulation IL25 TNF 2642531 1577556 Positive_regulation IL25 TNF 2659724 1577645 Positive_regulation IL25 TNF 2769183 1577870 Positive_regulation IL25 TNF 2785398 442912 Positive_regulation IL25 TNF 2803928 443133 Positive_regulation IL25 TNF 2833558 1578524 Positive_regulation IL25 TNF 3049617 1425450 Positive_regulation IL25 TNF 3049617 1425451 Positive_regulation IL25 TNF 3049617 1425558 Positive_regulation IL25 TNF 3049617 1425559 Positive_regulation IL25 TNF 3110354 1580043 Positive_regulation IL25 TNF 3137305 1580356 Positive_regulation IL25 TNF 3143799 1580411 Positive_regulation IL25 TNF 3290384 1580777 Positive_regulation IL25 TNF 3309124 1580895 Positive_regulation IL25 TNF 3309124 1580950 Positive_regulation IL25 TNF 3316469 1581010 Positive_regulation IL25 TNF 3411293 1581176 Positive_regulation IL25 TNF 3435706 443491 Positive_regulation IL25 TNF 3491174 1583081 Positive_regulation IL25 TNF 3494807 1583235 Positive_regulation IL25 TNF 3494807 1583236 Positive_regulation IL25 TNF 3494807 1583320 Positive_regulation IL25 TNF 3572302 1583459 Positive_regulation IL25 TNF 3598461 1583517 Positive_regulation IL25 TNF 3598461 1583552 Positive_regulation IL25 TNF 3819645 1583694 Positive_regulation IL25 TNF 8426121 1595186 Positive_regulation IL25 TNF 8478614 1595536 Positive_regulation IL25 TNF PMC2188223 1605385 Positive_regulation IL26 CD14 25025695 2989322 Positive_regulation IL26 IL1B 23055831 2280423 Positive_regulation IL26 IL1B 23055831 2280440 Positive_regulation IL26 LBP 25025695 2989323 Positive_regulation IL26 TLR7 11686880 3103116 Positive_regulation IL26 TNF 1311016 1528325 Positive_regulation IL26 TNF 1586593 426045 Positive_regulation IL26 TNF 1643416 702469 Positive_regulation IL26 TNF 1692079 1542180 Positive_regulation IL26 TNF 1717633 1543712 Positive_regulation IL26 TNF 18475440 1743764 Positive_regulation IL26 TNF 1911209 431566 Positive_regulation IL26 TNF 19742190 1048174 Positive_regulation IL26 TNF 19936089 981539 Positive_regulation IL26 TNF 2007858 1557293 Positive_regulation IL26 TNF 2022925 1557573 Positive_regulation IL26 TNF 2022925 1557601 Positive_regulation IL26 TNF 2039696 434755 Positive_regulation IL26 TNF 20808962 2473132 Positive_regulation IL26 TNF 21829352 3052642 Positive_regulation IL26 TNF 2183871 437500 Positive_regulation IL26 TNF 2183871 437563 Positive_regulation IL26 TNF 2183871 437564 Positive_regulation IL26 TNF 2183871 437611 Positive_regulation IL26 TNF 2258696 1568189 Positive_regulation IL26 TNF 23055831 2280439 Positive_regulation IL26 TNF 2373990 1572264 Positive_regulation IL26 TNF 2406363 1573695 Positive_regulation IL26 TNF 2499653 1576984 Positive_regulation IL26 TNF 2642531 1577561 Positive_regulation IL26 TNF 2659724 1577650 Positive_regulation IL26 TNF 2769183 1577875 Positive_regulation IL26 TNF 2785398 442917 Positive_regulation IL26 TNF 2803928 443138 Positive_regulation IL26 TNF 2833558 1578529 Positive_regulation IL26 TNF 3049617 1425460 Positive_regulation IL26 TNF 3049617 1425461 Positive_regulation IL26 TNF 3049617 1425568 Positive_regulation IL26 TNF 3049617 1425569 Positive_regulation IL26 TNF 3110354 1580048 Positive_regulation IL26 TNF 3137305 1580361 Positive_regulation IL26 TNF 3143799 1580416 Positive_regulation IL26 TNF 3290384 1580782 Positive_regulation IL26 TNF 3309124 1580900 Positive_regulation IL26 TNF 3309124 1580955 Positive_regulation IL26 TNF 3316469 1581015 Positive_regulation IL26 TNF 3411293 1581181 Positive_regulation IL26 TNF 3435706 443496 Positive_regulation IL26 TNF 3491174 1583086 Positive_regulation IL26 TNF 3494807 1583245 Positive_regulation IL26 TNF 3494807 1583246 Positive_regulation IL26 TNF 3494807 1583325 Positive_regulation IL26 TNF 3572302 1583464 Positive_regulation IL26 TNF 3598461 1583522 Positive_regulation IL26 TNF 3598461 1583557 Positive_regulation IL26 TNF 3819645 1583699 Positive_regulation IL26 TNF 8426121 1595191 Positive_regulation IL26 TNF 8478614 1595541 Positive_regulation IL26 TNF PMC2188223 1605390 Positive_regulation IL27 CD14 25025695 2989324 Positive_regulation IL27 LBP 25025695 2989325 Positive_regulation IL27 TLR7 11686880 3103126 Positive_regulation IL27 TNF 1311016 1528326 Positive_regulation IL27 TNF 1586593 426046 Positive_regulation IL27 TNF 1643416 702470 Positive_regulation IL27 TNF 1692079 1542181 Positive_regulation IL27 TNF 1717633 1543713 Positive_regulation IL27 TNF 18475440 1743765 Positive_regulation IL27 TNF 1911209 431567 Positive_regulation IL27 TNF 19742190 1048175 Positive_regulation IL27 TNF 19936089 981541 Positive_regulation IL27 TNF 2007858 1557294 Positive_regulation IL27 TNF 2022925 1557574 Positive_regulation IL27 TNF 2022925 1557602 Positive_regulation IL27 TNF 2039696 434756 Positive_regulation IL27 TNF 20808962 2473133 Positive_regulation IL27 TNF 21829352 3052647 Positive_regulation IL27 TNF 2183871 437501 Positive_regulation IL27 TNF 2183871 437565 Positive_regulation IL27 TNF 2183871 437566 Positive_regulation IL27 TNF 2183871 437612 Positive_regulation IL27 TNF 2258696 1568190 Positive_regulation IL27 TNF 2373990 1572265 Positive_regulation IL27 TNF 2406363 1573696 Positive_regulation IL27 TNF 2499653 1576985 Positive_regulation IL27 TNF 2642531 1577562 Positive_regulation IL27 TNF 2659724 1577651 Positive_regulation IL27 TNF 2769183 1577876 Positive_regulation IL27 TNF 2785398 442918 Positive_regulation IL27 TNF 2803928 443139 Positive_regulation IL27 TNF 2833558 1578530 Positive_regulation IL27 TNF 3049617 1425462 Positive_regulation IL27 TNF 3049617 1425463 Positive_regulation IL27 TNF 3049617 1425570 Positive_regulation IL27 TNF 3049617 1425571 Positive_regulation IL27 TNF 3110354 1580049 Positive_regulation IL27 TNF 3137305 1580362 Positive_regulation IL27 TNF 3143799 1580417 Positive_regulation IL27 TNF 3290384 1580783 Positive_regulation IL27 TNF 3309124 1580901 Positive_regulation IL27 TNF 3309124 1580956 Positive_regulation IL27 TNF 3316469 1581016 Positive_regulation IL27 TNF 3411293 1581182 Positive_regulation IL27 TNF 3435706 443497 Positive_regulation IL27 TNF 3491174 1583087 Positive_regulation IL27 TNF 3494807 1583247 Positive_regulation IL27 TNF 3494807 1583248 Positive_regulation IL27 TNF 3494807 1583326 Positive_regulation IL27 TNF 3572302 1583465 Positive_regulation IL27 TNF 3598461 1583523 Positive_regulation IL27 TNF 3598461 1583558 Positive_regulation IL27 TNF 3819645 1583700 Positive_regulation IL27 TNF 8426121 1595192 Positive_regulation IL27 TNF 8478614 1595542 Positive_regulation IL27 TNF PMC2188223 1605391 Positive_regulation IL2RA EPHB2 23586039 181269 Positive_regulation IL2RA EPHB2 23758320 151521 Positive_regulation IL2RA EPHB2 23758320 151522 Positive_regulation IL2RA MMP28 19509016 708887 Positive_regulation IL2RA MMP7 19509016 708902 Positive_regulation IL2RA STAT4 25336459 1733400 Positive_regulation IL2RA TNF 10637276 1514182 Positive_regulation IL2RA TNF 15289505 1533210 Positive_regulation IL2RA TNF 21124839 2484182 Positive_regulation IL2RA TNF 2831292 1578482 Positive_regulation IL2RA TNF 8691130 1598091 Positive_regulation IL2RB NGFR 21519548 85486 Positive_regulation IL2RB TNF 19570027 137360 Positive_regulation IL2RB TNF 19570027 137471 Positive_regulation IL2RB TNF 19570027 137480 Positive_regulation IL2RG TNF 24740375 2954698 Positive_regulation IL3 CD14 25025695 2989350 Positive_regulation IL3 EPHB2 22873932 532963 Positive_regulation IL3 LBP 25025695 2989351 Positive_regulation IL3 TLR7 11686880 3103256 Positive_regulation IL3 TNF 1311016 1528339 Positive_regulation IL3 TNF 1586593 426061 Positive_regulation IL3 TNF 1643416 702483 Positive_regulation IL3 TNF 1692079 1542194 Positive_regulation IL3 TNF 1717633 1543736 Positive_regulation IL3 TNF 18475440 1743778 Positive_regulation IL3 TNF 1911209 431581 Positive_regulation IL3 TNF 19742190 1048188 Positive_regulation IL3 TNF 19936089 981569 Positive_regulation IL3 TNF 2007858 1557308 Positive_regulation IL3 TNF 2022925 1557587 Positive_regulation IL3 TNF 2022925 1557615 Positive_regulation IL3 TNF 2039696 434769 Positive_regulation IL3 TNF 20808962 2473146 Positive_regulation IL3 TNF 21829352 3052755 Positive_regulation IL3 TNF 2183871 437516 Positive_regulation IL3 TNF 2183871 437591 Positive_regulation IL3 TNF 2183871 437592 Positive_regulation IL3 TNF 2183871 437626 Positive_regulation IL3 TNF 2258696 1568203 Positive_regulation IL3 TNF 2373990 1572278 Positive_regulation IL3 TNF 2406363 1573709 Positive_regulation IL3 TNF 2499653 1576998 Positive_regulation IL3 TNF 2642531 1577575 Positive_regulation IL3 TNF 2659724 1577664 Positive_regulation IL3 TNF 2769183 1577889 Positive_regulation IL3 TNF 2785398 442931 Positive_regulation IL3 TNF 2803928 443152 Positive_regulation IL3 TNF 2833558 1578543 Positive_regulation IL3 TNF 3049617 1425488 Positive_regulation IL3 TNF 3049617 1425489 Positive_regulation IL3 TNF 3049617 1425596 Positive_regulation IL3 TNF 3049617 1425597 Positive_regulation IL3 TNF 3110354 1580062 Positive_regulation IL3 TNF 3137305 1580375 Positive_regulation IL3 TNF 3143799 1580430 Positive_regulation IL3 TNF 3290384 1580796 Positive_regulation IL3 TNF 3309124 1580915 Positive_regulation IL3 TNF 3309124 1580969 Positive_regulation IL3 TNF 3316469 1581029 Positive_regulation IL3 TNF 3411293 1581195 Positive_regulation IL3 TNF 3435706 443510 Positive_regulation IL3 TNF 3491174 1583102 Positive_regulation IL3 TNF 3494807 1583273 Positive_regulation IL3 TNF 3494807 1583274 Positive_regulation IL3 TNF 3494807 1583340 Positive_regulation IL3 TNF 3572302 1583478 Positive_regulation IL3 TNF 3598461 1583537 Positive_regulation IL3 TNF 3598461 1583571 Positive_regulation IL3 TNF 3819645 1583713 Positive_regulation IL3 TNF 8426121 1595205 Positive_regulation IL3 TNF 8478614 1595555 Positive_regulation IL3 TNF PMC2188223 1605404 Positive_regulation IL3 TNFSF10 24367714 2372348 Positive_regulation IL31 CD14 25025695 2989326 Positive_regulation IL31 LBP 25025695 2989327 Positive_regulation IL31 TLR7 11686880 3103136 Positive_regulation IL31 TNF 1311016 1528327 Positive_regulation IL31 TNF 1586593 426047 Positive_regulation IL31 TNF 1643416 702471 Positive_regulation IL31 TNF 1692079 1542182 Positive_regulation IL31 TNF 1717633 1543714 Positive_regulation IL31 TNF 18475440 1743766 Positive_regulation IL31 TNF 1911209 431568 Positive_regulation IL31 TNF 19742190 1048176 Positive_regulation IL31 TNF 19936089 981543 Positive_regulation IL31 TNF 2007858 1557295 Positive_regulation IL31 TNF 2022925 1557575 Positive_regulation IL31 TNF 2022925 1557603 Positive_regulation IL31 TNF 2039696 434757 Positive_regulation IL31 TNF 20808962 2473134 Positive_regulation IL31 TNF 21829352 3052652 Positive_regulation IL31 TNF 2183871 437502 Positive_regulation IL31 TNF 2183871 437567 Positive_regulation IL31 TNF 2183871 437568 Positive_regulation IL31 TNF 2183871 437613 Positive_regulation IL31 TNF 2258696 1568191 Positive_regulation IL31 TNF 2373990 1572266 Positive_regulation IL31 TNF 23970959 140854 Positive_regulation IL31 TNF 2406363 1573697 Positive_regulation IL31 TNF 2499653 1576986 Positive_regulation IL31 TNF 2642531 1577563 Positive_regulation IL31 TNF 2659724 1577652 Positive_regulation IL31 TNF 2769183 1577877 Positive_regulation IL31 TNF 2785398 442919 Positive_regulation IL31 TNF 2803928 443140 Positive_regulation IL31 TNF 2833558 1578531 Positive_regulation IL31 TNF 3049617 1425464 Positive_regulation IL31 TNF 3049617 1425465 Positive_regulation IL31 TNF 3049617 1425572 Positive_regulation IL31 TNF 3049617 1425573 Positive_regulation IL31 TNF 3110354 1580050 Positive_regulation IL31 TNF 3137305 1580363 Positive_regulation IL31 TNF 3143799 1580418 Positive_regulation IL31 TNF 3290384 1580784 Positive_regulation IL31 TNF 3309124 1580902 Positive_regulation IL31 TNF 3309124 1580957 Positive_regulation IL31 TNF 3316469 1581017 Positive_regulation IL31 TNF 3411293 1581183 Positive_regulation IL31 TNF 3435706 443498 Positive_regulation IL31 TNF 3491174 1583088 Positive_regulation IL31 TNF 3494807 1583249 Positive_regulation IL31 TNF 3494807 1583250 Positive_regulation IL31 TNF 3494807 1583327 Positive_regulation IL31 TNF 3572302 1583466 Positive_regulation IL31 TNF 3598461 1583524 Positive_regulation IL31 TNF 3598461 1583559 Positive_regulation IL31 TNF 3819645 1583701 Positive_regulation IL31 TNF 8426121 1595193 Positive_regulation IL31 TNF 8478614 1595543 Positive_regulation IL31 TNF PMC2188223 1605392 Positive_regulation IL32 CD14 23190696 127471 Positive_regulation IL32 CD14 25025695 2989320 Positive_regulation IL32 LBP 25025695 2989321 Positive_regulation IL32 MIP 16903774 2368848 Positive_regulation IL32 MIP 22613074 125960 Positive_regulation IL32 TLR7 11686880 3103106 Positive_regulation IL32 TLR7 20615213 119584 Positive_regulation IL32 TLR7 20615213 119693 Positive_regulation IL32 TNF 1311016 1528324 Positive_regulation IL32 TNF 1586593 426044 Positive_regulation IL32 TNF 1643416 702468 Positive_regulation IL32 TNF 1692079 1542179 Positive_regulation IL32 TNF 1717633 1543711 Positive_regulation IL32 TNF 18475440 1743763 Positive_regulation IL32 TNF 1911209 431565 Positive_regulation IL32 TNF 19742190 1048173 Positive_regulation IL32 TNF 19922639 117880 Positive_regulation IL32 TNF 19936089 981537 Positive_regulation IL32 TNF 2007858 1557292 Positive_regulation IL32 TNF 2022925 1557572 Positive_regulation IL32 TNF 2022925 1557600 Positive_regulation IL32 TNF 2039696 434754 Positive_regulation IL32 TNF 20615213 119666 Positive_regulation IL32 TNF 20615213 119670 Positive_regulation IL32 TNF 20808962 2473131 Positive_regulation IL32 TNF 21829352 3052637 Positive_regulation IL32 TNF 2183871 437499 Positive_regulation IL32 TNF 2183871 437561 Positive_regulation IL32 TNF 2183871 437562 Positive_regulation IL32 TNF 2183871 437610 Positive_regulation IL32 TNF 2258696 1568188 Positive_regulation IL32 TNF 23148518 640131 Positive_regulation IL32 TNF 23148681 127281 Positive_regulation IL32 TNF 23190696 127470 Positive_regulation IL32 TNF 23703385 561853 Positive_regulation IL32 TNF 2373990 1572263 Positive_regulation IL32 TNF 2406363 1573694 Positive_regulation IL32 TNF 24884781 357560 Positive_regulation IL32 TNF 24884781 357561 Positive_regulation IL32 TNF 24884781 357568 Positive_regulation IL32 TNF 24884781 357574 Positive_regulation IL32 TNF 2499653 1576983 Positive_regulation IL32 TNF 25332857 3165779 Positive_regulation IL32 TNF 25332857 3165811 Positive_regulation IL32 TNF 25386048 1763146 Positive_regulation IL32 TNF 2642531 1577560 Positive_regulation IL32 TNF 2659724 1577649 Positive_regulation IL32 TNF 2769183 1577874 Positive_regulation IL32 TNF 2785398 442916 Positive_regulation IL32 TNF 2803928 443137 Positive_regulation IL32 TNF 2833558 1578528 Positive_regulation IL32 TNF 3049617 1425458 Positive_regulation IL32 TNF 3049617 1425459 Positive_regulation IL32 TNF 3049617 1425566 Positive_regulation IL32 TNF 3049617 1425567 Positive_regulation IL32 TNF 3110354 1580047 Positive_regulation IL32 TNF 3137305 1580360 Positive_regulation IL32 TNF 3143799 1580415 Positive_regulation IL32 TNF 3290384 1580781 Positive_regulation IL32 TNF 3309124 1580899 Positive_regulation IL32 TNF 3309124 1580954 Positive_regulation IL32 TNF 3316469 1581014 Positive_regulation IL32 TNF 3411293 1581180 Positive_regulation IL32 TNF 3435706 443495 Positive_regulation IL32 TNF 3491174 1583085 Positive_regulation IL32 TNF 3494807 1583243 Positive_regulation IL32 TNF 3494807 1583244 Positive_regulation IL32 TNF 3494807 1583324 Positive_regulation IL32 TNF 3572302 1583463 Positive_regulation IL32 TNF 3598461 1583521 Positive_regulation IL32 TNF 3598461 1583556 Positive_regulation IL32 TNF 3819645 1583698 Positive_regulation IL32 TNF 8426121 1595190 Positive_regulation IL32 TNF 8478614 1595540 Positive_regulation IL32 TNF PMC2188223 1605389 Positive_regulation IL33 CAPN8 21106488 1031222 Positive_regulation IL33 CCL17 22566963 900617 Positive_regulation IL33 CD14 25025695 2989290 Positive_regulation IL33 EPHB2 22246057 1086367 Positive_regulation IL33 EPHB2 22246057 1086368 Positive_regulation IL33 EPHB2 23418608 2754890 Positive_regulation IL33 EPHB2 23418608 2754891 Positive_regulation IL33 EPHB2 23418608 2754900 Positive_regulation IL33 HES2 24496315 1920353 Positive_regulation IL33 IL1B 24151520 638779 Positive_regulation IL33 LBP 25025695 2989291 Positive_regulation IL33 MUC16 21695271 2530142 Positive_regulation IL33 TLR7 11686880 3103096 Positive_regulation IL33 TLR7 23169007 808709 Positive_regulation IL33 TLR7 23653627 906973 Positive_regulation IL33 TNF 1311016 1528323 Positive_regulation IL33 TNF 1586593 426043 Positive_regulation IL33 TNF 1643416 702467 Positive_regulation IL33 TNF 1692079 1542178 Positive_regulation IL33 TNF 1717633 1543710 Positive_regulation IL33 TNF 18475440 1743762 Positive_regulation IL33 TNF 1911209 431564 Positive_regulation IL33 TNF 19519923 113520 Positive_regulation IL33 TNF 19742190 1048172 Positive_regulation IL33 TNF 19936089 981535 Positive_regulation IL33 TNF 2007858 1557291 Positive_regulation IL33 TNF 2022925 1557571 Positive_regulation IL33 TNF 2022925 1557599 Positive_regulation IL33 TNF 2039696 434753 Positive_regulation IL33 TNF 20808962 2473130 Positive_regulation IL33 TNF 21829352 3052632 Positive_regulation IL33 TNF 2183871 437498 Positive_regulation IL33 TNF 2183871 437559 Positive_regulation IL33 TNF 2183871 437560 Positive_regulation IL33 TNF 2183871 437609 Positive_regulation IL33 TNF 22246057 1086362 Positive_regulation IL33 TNF 22246057 1086363 Positive_regulation IL33 TNF 22246057 1086364 Positive_regulation IL33 TNF 22246057 1086391 Positive_regulation IL33 TNF 22246057 1086392 Positive_regulation IL33 TNF 22246057 1086402 Positive_regulation IL33 TNF 22566963 900597 Positive_regulation IL33 TNF 22566963 900618 Positive_regulation IL33 TNF 2258696 1568187 Positive_regulation IL33 TNF 23062310 856172 Positive_regulation IL33 TNF 23301222 89164 Positive_regulation IL33 TNF 23418608 2754888 Positive_regulation IL33 TNF 23418608 2754889 Positive_regulation IL33 TNF 23418608 2754899 Positive_regulation IL33 TNF 23418608 2754909 Positive_regulation IL33 TNF 23418608 2754910 Positive_regulation IL33 TNF 23567618 1642604 Positive_regulation IL33 TNF 23567618 1642610 Positive_regulation IL33 TNF 23567618 1642613 Positive_regulation IL33 TNF 23567618 1642619 Positive_regulation IL33 TNF 23567618 1642646 Positive_regulation IL33 TNF 23567618 1642650 Positive_regulation IL33 TNF 23675190 1064654 Positive_regulation IL33 TNF 2373990 1572262 Positive_regulation IL33 TNF 23967327 2837410 Positive_regulation IL33 TNF 23967327 2837432 Positive_regulation IL33 TNF 2406363 1573693 Positive_regulation IL33 TNF 24151520 638776 Positive_regulation IL33 TNF 24151520 638777 Positive_regulation IL33 TNF 24314293 314636 Positive_regulation IL33 TNF 24551140 2923179 Positive_regulation IL33 TNF 24692848 1757883 Positive_regulation IL33 TNF 24822215 190620 Positive_regulation IL33 TNF 2499653 1576982 Positive_regulation IL33 TNF 25032216 194828 Positive_regulation IL33 TNF 2642531 1577559 Positive_regulation IL33 TNF 2659724 1577648 Positive_regulation IL33 TNF 2769183 1577873 Positive_regulation IL33 TNF 2785398 442915 Positive_regulation IL33 TNF 2803928 443136 Positive_regulation IL33 TNF 2833558 1578527 Positive_regulation IL33 TNF 3049617 1425456 Positive_regulation IL33 TNF 3049617 1425457 Positive_regulation IL33 TNF 3049617 1425564 Positive_regulation IL33 TNF 3049617 1425565 Positive_regulation IL33 TNF 3110354 1580046 Positive_regulation IL33 TNF 3137305 1580359 Positive_regulation IL33 TNF 3143799 1580414 Positive_regulation IL33 TNF 3290384 1580780 Positive_regulation IL33 TNF 3309124 1580898 Positive_regulation IL33 TNF 3309124 1580953 Positive_regulation IL33 TNF 3316469 1581013 Positive_regulation IL33 TNF 3411293 1581179 Positive_regulation IL33 TNF 3435706 443494 Positive_regulation IL33 TNF 3491174 1583084 Positive_regulation IL33 TNF 3494807 1583241 Positive_regulation IL33 TNF 3494807 1583242 Positive_regulation IL33 TNF 3494807 1583323 Positive_regulation IL33 TNF 3572302 1583462 Positive_regulation IL33 TNF 3598461 1583520 Positive_regulation IL33 TNF 3598461 1583555 Positive_regulation IL33 TNF 3819645 1583697 Positive_regulation IL33 TNF 8426121 1595189 Positive_regulation IL33 TNF 8478614 1595539 Positive_regulation IL33 TNF PMC2188223 1605388 Positive_regulation IL33 TNF PMC2874290 35112 Positive_regulation IL34 CD14 25025695 2989328 Positive_regulation IL34 FUT4 23409120 2753568 Positive_regulation IL34 LBP 25025695 2989329 Positive_regulation IL34 TLR7 11686880 3103146 Positive_regulation IL34 TNF 1311016 1528328 Positive_regulation IL34 TNF 1586593 426048 Positive_regulation IL34 TNF 1643416 702472 Positive_regulation IL34 TNF 1692079 1542183 Positive_regulation IL34 TNF 1717633 1543720 Positive_regulation IL34 TNF 18475440 1743767 Positive_regulation IL34 TNF 1911209 431570 Positive_regulation IL34 TNF 19742190 1048177 Positive_regulation IL34 TNF 19936089 981547 Positive_regulation IL34 TNF 2007858 1557297 Positive_regulation IL34 TNF 2022925 1557576 Positive_regulation IL34 TNF 2022925 1557604 Positive_regulation IL34 TNF 2039696 434758 Positive_regulation IL34 TNF 20808962 2473135 Positive_regulation IL34 TNF 21829352 3052657 Positive_regulation IL34 TNF 2183871 437504 Positive_regulation IL34 TNF 2183871 437569 Positive_regulation IL34 TNF 2183871 437570 Positive_regulation IL34 TNF 2183871 437614 Positive_regulation IL34 TNF 2258696 1568192 Positive_regulation IL34 TNF 2373990 1572267 Positive_regulation IL34 TNF 2406363 1573698 Positive_regulation IL34 TNF 24339952 2894352 Positive_regulation IL34 TNF 24339952 2894372 Positive_regulation IL34 TNF 24339952 2894378 Positive_regulation IL34 TNF 24339952 2894383 Positive_regulation IL34 TNF 24970360 1886467 Positive_regulation IL34 TNF 2499653 1576987 Positive_regulation IL34 TNF 2642531 1577564 Positive_regulation IL34 TNF 2659724 1577653 Positive_regulation IL34 TNF 2769183 1577878 Positive_regulation IL34 TNF 2785398 442920 Positive_regulation IL34 TNF 2803928 443141 Positive_regulation IL34 TNF 2833558 1578532 Positive_regulation IL34 TNF 3049617 1425466 Positive_regulation IL34 TNF 3049617 1425467 Positive_regulation IL34 TNF 3049617 1425574 Positive_regulation IL34 TNF 3049617 1425575 Positive_regulation IL34 TNF 3110354 1580051 Positive_regulation IL34 TNF 3137305 1580364 Positive_regulation IL34 TNF 3143799 1580419 Positive_regulation IL34 TNF 3290384 1580785 Positive_regulation IL34 TNF 3309124 1580903 Positive_regulation IL34 TNF 3309124 1580958 Positive_regulation IL34 TNF 3316469 1581018 Positive_regulation IL34 TNF 3411293 1581184 Positive_regulation IL34 TNF 3435706 443499 Positive_regulation IL34 TNF 3491174 1583089 Positive_regulation IL34 TNF 3494807 1583251 Positive_regulation IL34 TNF 3494807 1583252 Positive_regulation IL34 TNF 3494807 1583328 Positive_regulation IL34 TNF 3572302 1583467 Positive_regulation IL34 TNF 3598461 1583525 Positive_regulation IL34 TNF 3598461 1583560 Positive_regulation IL34 TNF 3819645 1583702 Positive_regulation IL34 TNF 8426121 1595194 Positive_regulation IL34 TNF 8478614 1595544 Positive_regulation IL34 TNF PMC2188223 1605393 Positive_regulation IL36B TNF 16646978 105910 Positive_regulation IL36B TNF 16646978 105931 Positive_regulation IL37 CD14 25025695 2989288 Positive_regulation IL37 LBP 25025695 2989289 Positive_regulation IL37 TLR7 11686880 3103059 Positive_regulation IL37 TLR7 20935647 1954488 Positive_regulation IL37 TLR7 20935647 1954514 Positive_regulation IL37 TLR7 25226272 3007695 Positive_regulation IL37 TNF 1311016 1528322 Positive_regulation IL37 TNF 1586593 426042 Positive_regulation IL37 TNF 1643416 702466 Positive_regulation IL37 TNF 1692079 1542177 Positive_regulation IL37 TNF 1717633 1543709 Positive_regulation IL37 TNF 18475440 1743761 Positive_regulation IL37 TNF 1911209 431563 Positive_regulation IL37 TNF 19742190 1048171 Positive_regulation IL37 TNF 19936089 981533 Positive_regulation IL37 TNF 2007858 1557290 Positive_regulation IL37 TNF 2022925 1557570 Positive_regulation IL37 TNF 2022925 1557598 Positive_regulation IL37 TNF 2039696 434752 Positive_regulation IL37 TNF 20808962 2473129 Positive_regulation IL37 TNF 20935647 1954513 Positive_regulation IL37 TNF 21829352 3052627 Positive_regulation IL37 TNF 2183871 437497 Positive_regulation IL37 TNF 2183871 437557 Positive_regulation IL37 TNF 2183871 437558 Positive_regulation IL37 TNF 2183871 437608 Positive_regulation IL37 TNF 2258696 1568186 Positive_regulation IL37 TNF 2373990 1572261 Positive_regulation IL37 TNF 2406363 1573692 Positive_regulation IL37 TNF 2499653 1576981 Positive_regulation IL37 TNF 25214710 1762093 Positive_regulation IL37 TNF 2642531 1577558 Positive_regulation IL37 TNF 2659724 1577647 Positive_regulation IL37 TNF 2769183 1577872 Positive_regulation IL37 TNF 2785398 442914 Positive_regulation IL37 TNF 2803928 443135 Positive_regulation IL37 TNF 2833558 1578526 Positive_regulation IL37 TNF 3049617 1425454 Positive_regulation IL37 TNF 3049617 1425455 Positive_regulation IL37 TNF 3049617 1425562 Positive_regulation IL37 TNF 3049617 1425563 Positive_regulation IL37 TNF 3110354 1580045 Positive_regulation IL37 TNF 3137305 1580358 Positive_regulation IL37 TNF 3143799 1580413 Positive_regulation IL37 TNF 3290384 1580779 Positive_regulation IL37 TNF 3309124 1580897 Positive_regulation IL37 TNF 3309124 1580952 Positive_regulation IL37 TNF 3316469 1581012 Positive_regulation IL37 TNF 3411293 1581178 Positive_regulation IL37 TNF 3435706 443493 Positive_regulation IL37 TNF 3491174 1583083 Positive_regulation IL37 TNF 3494807 1583239 Positive_regulation IL37 TNF 3494807 1583240 Positive_regulation IL37 TNF 3494807 1583322 Positive_regulation IL37 TNF 3572302 1583461 Positive_regulation IL37 TNF 3598461 1583519 Positive_regulation IL37 TNF 3598461 1583554 Positive_regulation IL37 TNF 3819645 1583696 Positive_regulation IL37 TNF 8426121 1595188 Positive_regulation IL37 TNF 8478614 1595538 Positive_regulation IL37 TNF PMC2188223 1605387 Positive_regulation IL4 ALOX5 12235216 1524886 Positive_regulation IL4 ARSA 21829647 2542226 Positive_regulation IL4 CCL17 23999500 1573555 Positive_regulation IL4 CD14 25025695 2989352 Positive_regulation IL4 CHI3L1 24416647 1708189 Positive_regulation IL4 EPHB2 20826917 736522 Positive_regulation IL4 EPHB2 21989417 1041843 Positive_regulation IL4 EPHB2 21989417 1041844 Positive_regulation IL4 EPHB2 21989417 1041845 Positive_regulation IL4 EPHB2 21989417 1041846 Positive_regulation IL4 EPHB2 21989417 1041847 Positive_regulation IL4 EPHB2 21989417 1041848 Positive_regulation IL4 EPHB2 21989417 1041863 Positive_regulation IL4 EPHB2 21989417 1041875 Positive_regulation IL4 ITGAL 1402683 1528918 Positive_regulation IL4 JAG1 18665263 2394139 Positive_regulation IL4 LBP 23517687 294304 Positive_regulation IL4 LBP 25025695 2989353 Positive_regulation IL4 MIP 18955794 1635057 Positive_regulation IL4 MIP 20544034 2452638 Positive_regulation IL4 MUC16 15203548 1739562 Positive_regulation IL4 MUC16 20725596 3225154 Positive_regulation IL4 MUC16 21695271 2530188 Positive_regulation IL4 NES 19406170 1770202 Positive_regulation IL4 RORC 22473038 1957040 Positive_regulation IL4 RORC 24453425 1756980 Positive_regulation IL4 STAT4 9743537 1603898 Positive_regulation IL4 TCN1 7595220 1590907 Positive_regulation IL4 TLR7 11686880 3103266 Positive_regulation IL4 TLR7 21364926 2504469 Positive_regulation IL4 TLR7 21533209 2515576 Positive_regulation IL4 TLR7 23194300 356092 Positive_regulation IL4 TNF 11748272 1521969 Positive_regulation IL4 TNF 1311016 1528340 Positive_regulation IL4 TNF 14638848 1529848 Positive_regulation IL4 TNF 15144561 648847 Positive_regulation IL4 TNF 15770065 1740016 Positive_regulation IL4 TNF 1586593 426062 Positive_regulation IL4 TNF 1643416 702484 Positive_regulation IL4 TNF 1692079 1542195 Positive_regulation IL4 TNF 1717633 1543737 Positive_regulation IL4 TNF 18475440 1743779 Positive_regulation IL4 TNF 1911209 431582 Positive_regulation IL4 TNF 19281078 1071693 Positive_regulation IL4 TNF 19281078 1071695 Positive_regulation IL4 TNF 19742190 1048189 Positive_regulation IL4 TNF 19936089 981571 Positive_regulation IL4 TNF 2007858 1557309 Positive_regulation IL4 TNF 2022925 1557588 Positive_regulation IL4 TNF 2022925 1557616 Positive_regulation IL4 TNF 2039696 434770 Positive_regulation IL4 TNF 20544034 2452635 Positive_regulation IL4 TNF 20733031 1559600 Positive_regulation IL4 TNF 20808962 2473147 Positive_regulation IL4 TNF 21106069 1621037 Positive_regulation IL4 TNF 21829284 1146057 Positive_regulation IL4 TNF 21829352 3052760 Positive_regulation IL4 TNF 2183871 437517 Positive_regulation IL4 TNF 2183871 437593 Positive_regulation IL4 TNF 2183871 437594 Positive_regulation IL4 TNF 2183871 437627 Positive_regulation IL4 TNF 22457616 3055884 Positive_regulation IL4 TNF 22547990 3152584 Positive_regulation IL4 TNF 2258696 1568204 Positive_regulation IL4 TNF 2373990 1572279 Positive_regulation IL4 TNF 2406363 1573710 Positive_regulation IL4 TNF 24550673 1138206 Positive_regulation IL4 TNF 24655411 19997 Positive_regulation IL4 TNF 24688608 2208338 Positive_regulation IL4 TNF 2499653 1576999 Positive_regulation IL4 TNF 25101851 2995825 Positive_regulation IL4 TNF 2642531 1577576 Positive_regulation IL4 TNF 2659724 1577665 Positive_regulation IL4 TNF 2677211 1577819 Positive_regulation IL4 TNF 2769183 1577890 Positive_regulation IL4 TNF 2785398 442932 Positive_regulation IL4 TNF 2803928 443153 Positive_regulation IL4 TNF 2833558 1578544 Positive_regulation IL4 TNF 3049617 1425490 Positive_regulation IL4 TNF 3049617 1425491 Positive_regulation IL4 TNF 3049617 1425598 Positive_regulation IL4 TNF 3049617 1425599 Positive_regulation IL4 TNF 3110354 1580063 Positive_regulation IL4 TNF 3137305 1580376 Positive_regulation IL4 TNF 3143799 1580431 Positive_regulation IL4 TNF 3290384 1580797 Positive_regulation IL4 TNF 3309124 1580916 Positive_regulation IL4 TNF 3309124 1580970 Positive_regulation IL4 TNF 3316469 1581030 Positive_regulation IL4 TNF 3411293 1581196 Positive_regulation IL4 TNF 3435706 443511 Positive_regulation IL4 TNF 3491174 1583103 Positive_regulation IL4 TNF 3494807 1583275 Positive_regulation IL4 TNF 3494807 1583276 Positive_regulation IL4 TNF 3494807 1583341 Positive_regulation IL4 TNF 3572302 1583479 Positive_regulation IL4 TNF 3598461 1583538 Positive_regulation IL4 TNF 3598461 1583572 Positive_regulation IL4 TNF 3819645 1583714 Positive_regulation IL4 TNF 8426121 1595206 Positive_regulation IL4 TNF 8478614 1595556 Positive_regulation IL4 TNF 9126933 1601102 Positive_regulation IL4 TNF PMC2188223 1605405 Positive_regulation IL4 ZBTB16 22473038 1957041 Positive_regulation IL4I1 RORC 24151516 638703 Positive_regulation IL5 CD14 25025695 2989354 Positive_regulation IL5 IL1B 11132773 1737250 Positive_regulation IL5 LBP 25025695 2989355 Positive_regulation IL5 MATN2 24895400 1487892 Positive_regulation IL5 MATN2 24895400 1487948 Positive_regulation IL5 TCN1 22750193 1492588 Positive_regulation IL5 TLR7 11686880 3103276 Positive_regulation IL5 TLR7 23533311 1751818 Positive_regulation IL5 TNF 11132773 1737249 Positive_regulation IL5 TNF 1311016 1528341 Positive_regulation IL5 TNF 1586593 426063 Positive_regulation IL5 TNF 1643416 702485 Positive_regulation IL5 TNF 1692079 1542196 Positive_regulation IL5 TNF 1717633 1543738 Positive_regulation IL5 TNF 18475440 1743780 Positive_regulation IL5 TNF 1911209 431583 Positive_regulation IL5 TNF 19742190 1048190 Positive_regulation IL5 TNF 19936089 981573 Positive_regulation IL5 TNF 2007858 1557310 Positive_regulation IL5 TNF 2022925 1557589 Positive_regulation IL5 TNF 2022925 1557617 Positive_regulation IL5 TNF 2039696 434771 Positive_regulation IL5 TNF 20808962 2473148 Positive_regulation IL5 TNF 21829352 3052765 Positive_regulation IL5 TNF 2183871 437518 Positive_regulation IL5 TNF 2183871 437595 Positive_regulation IL5 TNF 2183871 437596 Positive_regulation IL5 TNF 2183871 437628 Positive_regulation IL5 TNF 2258696 1568205 Positive_regulation IL5 TNF 23342266 491910 Positive_regulation IL5 TNF 2373990 1572280 Positive_regulation IL5 TNF 2406363 1573711 Positive_regulation IL5 TNF 24587316 2929405 Positive_regulation IL5 TNF 24651069 2372474 Positive_regulation IL5 TNF 2499653 1577000 Positive_regulation IL5 TNF 2642531 1577577 Positive_regulation IL5 TNF 2659724 1577666 Positive_regulation IL5 TNF 2769183 1577891 Positive_regulation IL5 TNF 2785398 442933 Positive_regulation IL5 TNF 2803928 443154 Positive_regulation IL5 TNF 2833558 1578545 Positive_regulation IL5 TNF 3049617 1425492 Positive_regulation IL5 TNF 3049617 1425493 Positive_regulation IL5 TNF 3049617 1425600 Positive_regulation IL5 TNF 3049617 1425601 Positive_regulation IL5 TNF 3110354 1580064 Positive_regulation IL5 TNF 3137305 1580377 Positive_regulation IL5 TNF 3143799 1580432 Positive_regulation IL5 TNF 3290384 1580798 Positive_regulation IL5 TNF 3309124 1580917 Positive_regulation IL5 TNF 3309124 1580971 Positive_regulation IL5 TNF 3316469 1581031 Positive_regulation IL5 TNF 3411293 1581197 Positive_regulation IL5 TNF 3435706 443512 Positive_regulation IL5 TNF 3491174 1583104 Positive_regulation IL5 TNF 3494807 1583277 Positive_regulation IL5 TNF 3494807 1583278 Positive_regulation IL5 TNF 3494807 1583342 Positive_regulation IL5 TNF 3572302 1583480 Positive_regulation IL5 TNF 3598461 1583539 Positive_regulation IL5 TNF 3598461 1583573 Positive_regulation IL5 TNF 3819645 1583715 Positive_regulation IL5 TNF 8426121 1595207 Positive_regulation IL5 TNF 8478614 1595557 Positive_regulation IL5 TNF 9207003 1601262 Positive_regulation IL5 TNF PMC2188223 1605406 Positive_regulation IL6 ALOX5 18475433 1743413 Positive_regulation IL6 ALOX5 22277352 124682 Positive_regulation IL6 CAPN8 22046434 2567806 Positive_regulation IL6 CAPN8 22046434 2567807 Positive_regulation IL6 CAPN8 22046434 2567808 Positive_regulation IL6 CD14 10075974 1511207 Positive_regulation IL6 CD14 12061425 1738150 Positive_regulation IL6 CD14 17242961 810082 Positive_regulation IL6 CD14 18475735 1745914 Positive_regulation IL6 CD14 20946675 1723278 Positive_regulation IL6 CD14 20946675 1723317 Positive_regulation IL6 CD14 20946675 1723337 Positive_regulation IL6 CD14 23803652 1108022 Positive_regulation IL6 CD14 24138989 410764 Positive_regulation IL6 CD14 24278676 3150028 Positive_regulation IL6 CD14 24489448 1757430 Positive_regulation IL6 CD14 25025695 2989356 Positive_regulation IL6 CD14 7500012 1587098 Positive_regulation IL6 CD14 7500012 1587099 Positive_regulation IL6 CEACAM6 23554642 1225817 Positive_regulation IL6 CEACAM6 23554642 1225818 Positive_regulation IL6 CEACAM6 23554642 1225820 Positive_regulation IL6 CHI3L1 8642284 1596633 Positive_regulation IL6 CLU 17634137 1645584 Positive_regulation IL6 CTGF 23227240 2725706 Positive_regulation IL6 CTGF 23227240 2725707 Positive_regulation IL6 CTGF 23227240 2725712 Positive_regulation IL6 CTGF 23227240 2725713 Positive_regulation IL6 CTGF 23227240 2725718 Positive_regulation IL6 CTGF 23227240 2725719 Positive_regulation IL6 CTGF 23227240 2725720 Positive_regulation IL6 CTGF 23227240 2725729 Positive_regulation IL6 CTGF 23227240 2725733 Positive_regulation IL6 CTGF 23227240 2725734 Positive_regulation IL6 CTGF 23227240 2725735 Positive_regulation IL6 CTGF 23227240 2725736 Positive_regulation IL6 CTGF 23227240 2725741 Positive_regulation IL6 CTGF 23227240 2725742 Positive_regulation IL6 CTGF 23227240 2725749 Positive_regulation IL6 CTGF 23227240 2725762 Positive_regulation IL6 EDN2 18195069 1548326 Positive_regulation IL6 EDN2 18195069 1548327 Positive_regulation IL6 EDN2 18195069 1548328 Positive_regulation IL6 EDN2 18195069 1548329 Positive_regulation IL6 EDN2 18195069 1548390 Positive_regulation IL6 EDN2 18195069 1548391 Positive_regulation IL6 EDN2 18195069 1548465 Positive_regulation IL6 EDN2 21375761 1697088 Positive_regulation IL6 EPHB2 15210742 1533005 Positive_regulation IL6 EPHB2 19133134 1625203 Positive_regulation IL6 EPHB2 19348674 1625305 Positive_regulation IL6 EPHB2 20161729 2440509 Positive_regulation IL6 EPHB2 20830230 1711859 Positive_regulation IL6 EPHB2 21054880 508236 Positive_regulation IL6 EPHB2 21122157 1860346 Positive_regulation IL6 EPHB2 21122157 1860366 Positive_regulation IL6 EPHB2 21829524 2541566 Positive_regulation IL6 EPHB2 22096605 2571919 Positive_regulation IL6 EPHB2 22736938 1914549 Positive_regulation IL6 EPHB2 22736938 1914556 Positive_regulation IL6 EPHB2 23300722 2735648 Positive_regulation IL6 EPHB2 23343403 127789 Positive_regulation IL6 EPHB2 23396374 16955 Positive_regulation IL6 EPHB2 23405061 2751548 Positive_regulation IL6 EPHB2 23554896 2773619 Positive_regulation IL6 EPHB2 23936328 2829942 Positive_regulation IL6 EPHB2 24191131 1755001 Positive_regulation IL6 EPHB2 24404333 206104 Positive_regulation IL6 EPHB2 24421891 2909255 Positive_regulation IL6 EPHB2 24566135 1124039 Positive_regulation IL6 EPHB2 24566135 1124041 Positive_regulation IL6 EPHB2 24782592 1758330 Positive_regulation IL6 EPHB2 24913620 391432 Positive_regulation IL6 EPHB2 25390332 3025248 Positive_regulation IL6 F2R 17480240 279749 Positive_regulation IL6 F2R 21464892 2510284 Positive_regulation IL6 F2R 24015257 2842551 Positive_regulation IL6 F2R 25313362 201343 Positive_regulation IL6 FAS 23305094 1725206 Positive_regulation IL6 FOXO1 20426802 1723013 Positive_regulation IL6 FOXO1 24864265 191802 Positive_regulation IL6 GAB3 20689230 3079089 Positive_regulation IL6 ID1 20010941 434213 Positive_regulation IL6 ID1 20010941 434216 Positive_regulation IL6 IL1B 12745542 1738310 Positive_regulation IL6 IL1B 12745542 1738311 Positive_regulation IL6 IL1B 16126496 1049562 Positive_regulation IL6 IL1B 16126496 1049563 Positive_regulation IL6 IL1B 17162354 630471 Positive_regulation IL6 IL1B 18472850 1742279 Positive_regulation IL6 IL1B 21729870 2064266 Positive_regulation IL6 IL1B 22611374 833064 Positive_regulation IL6 IL1B 24489848 2916455 Positive_regulation IL6 IL1B 24715926 515395 Positive_regulation IL6 IL1B 25346723 881270 Positive_regulation IL6 IL1B 25436109 1161819 Positive_regulation IL6 IL1B 25530684 1763483 Positive_regulation IL6 IL1B 25530684 1763484 Positive_regulation IL6 IL1B 9400742 797440 Positive_regulation IL6 IL1B PMC3242278 1702650 Positive_regulation IL6 IL6R 20671912 1747529 Positive_regulation IL6 IL6R 22421340 1718690 Positive_regulation IL6 IL6R 23995732 1929401 Positive_regulation IL6 IL6R 24501689 2163025 Positive_regulation IL6 IL6R 25276782 200268 Positive_regulation IL6 JAG1 21637390 1038173 Positive_regulation IL6 JAG1 25147739 413724 Positive_regulation IL6 LAMB3 23024638 925228 Positive_regulation IL6 LBP 23125878 1641425 Positive_regulation IL6 LBP 23803652 1108023 Positive_regulation IL6 LBP 25025695 2989357 Positive_regulation IL6 LBP 7500012 1587101 Positive_regulation IL6 LINC00284 25431574 915414 Positive_regulation IL6 LINC00284 25431574 917801 Positive_regulation IL6 LINC00341 25431574 915374 Positive_regulation IL6 LINC00341 25431574 917761 Positive_regulation IL6 MAP2K6 10544198 1512874 Positive_regulation IL6 MAP2K6 21054880 508247 Positive_regulation IL6 MAP2K6 21122157 1860355 Positive_regulation IL6 MAP2K6 21122157 1860375 Positive_regulation IL6 MAP2K6 24400116 2905769 Positive_regulation IL6 MIP 10931794 789721 Positive_regulation IL6 MIP 21747807 923190 Positive_regulation IL6 MIP 22899878 1750203 Positive_regulation IL6 MIP 24058610 2848249 Positive_regulation IL6 MIP 24376630 2901547 Positive_regulation IL6 MUC16 17352829 3107915 Positive_regulation IL6 MUC16 21331365 632383 Positive_regulation IL6 MUC16 21695271 2530203 Positive_regulation IL6 NT5E 24987392 913201 Positive_regulation IL6 PGC 23050972 89639 Positive_regulation IL6 PGC 23240005 2727184 Positive_regulation IL6 PTGER2 21209948 2492563 Positive_regulation IL6 PTGER2 23331485 1675536 Positive_regulation IL6 PTGER2 25229003 82545 Positive_regulation IL6 PTGER2 25229003 82614 Positive_regulation IL6 RNASE1 21953341 90927 Positive_regulation IL6 RNASE7 21953341 90935 Positive_regulation IL6 RORC 24013901 2842176 Positive_regulation IL6 RORC 24453425 1756985 Positive_regulation IL6 S100A7 22230654 3112893 Positive_regulation IL6 S100B 20862385 513135 Positive_regulation IL6 S100B 24084731 1113179 Positive_regulation IL6 S100B PMC4070603 3206025 Positive_regulation IL6 TLR7 11686880 3103286 Positive_regulation IL6 TLR7 16542467 105109 Positive_regulation IL6 TLR7 17485511 1545644 Positive_regulation IL6 TLR7 17485512 1545931 Positive_regulation IL6 TLR7 17850179 2263321 Positive_regulation IL6 TLR7 17895997 2378764 Positive_regulation IL6 TLR7 18066067 1951733 Positive_regulation IL6 TLR7 18227218 1548901 Positive_regulation IL6 TLR7 18268037 1549345 Positive_regulation IL6 TLR7 18268037 1549346 Positive_regulation IL6 TLR7 18779348 1551939 Positive_regulation IL6 TLR7 19047436 1552969 Positive_regulation IL6 TLR7 19108028 3231564 Positive_regulation IL6 TLR7 19183807 2405112 Positive_regulation IL6 TLR7 19325820 1087888 Positive_regulation IL6 TLR7 19363483 1952389 Positive_regulation IL6 TLR7 19363483 1952390 Positive_regulation IL6 TLR7 19430534 2416212 Positive_regulation IL6 TLR7 19430534 2416213 Positive_regulation IL6 TLR7 19430534 2416258 Positive_regulation IL6 TLR7 19430534 2416325 Positive_regulation IL6 TLR7 19564352 1555348 Positive_regulation IL6 TLR7 19668221 1952748 Positive_regulation IL6 TLR7 19703985 1555924 Positive_regulation IL6 TLR7 19806220 2427831 Positive_regulation IL6 TLR7 20457757 1558223 Positive_regulation IL6 TLR7 20584912 1377109 Positive_regulation IL6 TLR7 20617179 3047873 Positive_regulation IL6 TLR7 20628526 1747467 Positive_regulation IL6 TLR7 20680494 1654643 Positive_regulation IL6 TLR7 20703784 1491338 Positive_regulation IL6 TLR7 20706689 1747843 Positive_regulation IL6 TLR7 20837769 1379101 Positive_regulation IL6 TLR7 20877569 2475374 Positive_regulation IL6 TLR7 21098092 1561841 Positive_regulation IL6 TLR7 21115688 1562049 Positive_regulation IL6 TLR7 21115688 1562061 Positive_regulation IL6 TLR7 21188217 1081632 Positive_regulation IL6 TLR7 21533209 2515534 Positive_regulation IL6 TLR7 21789039 979912 Positive_regulation IL6 TLR7 21829730 2542564 Positive_regulation IL6 TLR7 21829730 2542584 Positive_regulation IL6 TLR7 21912648 2552558 Positive_regulation IL6 TLR7 21953341 90973 Positive_regulation IL6 TLR7 21994612 3218955 Positive_regulation IL6 TLR7 22125636 2573648 Positive_regulation IL6 TLR7 22164330 97568 Positive_regulation IL6 TLR7 22218461 1086217 Positive_regulation IL6 TLR7 22484733 1957123 Positive_regulation IL6 TLR7 22484733 1957194 Positive_regulation IL6 TLR7 22513098 125465 Positive_regulation IL6 TLR7 22523644 1680623 Positive_regulation IL6 TLR7 22661952 957545 Positive_regulation IL6 TLR7 22726246 3214724 Positive_regulation IL6 TLR7 22726246 3214745 Positive_regulation IL6 TLR7 22751696 723607 Positive_regulation IL6 TLR7 22751696 723608 Positive_regulation IL6 TLR7 22751696 723609 Positive_regulation IL6 TLR7 22751696 723610 Positive_regulation IL6 TLR7 22751696 723611 Positive_regulation IL6 TLR7 22751696 723667 Positive_regulation IL6 TLR7 22751696 723687 Positive_regulation IL6 TLR7 22751696 723712 Positive_regulation IL6 TLR7 22751696 723713 Positive_regulation IL6 TLR7 22802904 2219250 Positive_regulation IL6 TLR7 22876243 902879 Positive_regulation IL6 TLR7 22883744 1664723 Positive_regulation IL6 TLR7 23049242 1224905 Positive_regulation IL6 TLR7 23061052 863726 Positive_regulation IL6 TLR7 23061052 863759 Positive_regulation IL6 TLR7 23071254 1569680 Positive_regulation IL6 TLR7 23239947 3229369 Positive_regulation IL6 TLR7 23460827 2759541 Positive_regulation IL6 TLR7 23506673 1036585 Positive_regulation IL6 TLR7 23557436 359104 Positive_regulation IL6 TLR7 23557436 359105 Positive_regulation IL6 TLR7 23758787 1649622 Positive_regulation IL6 TLR7 23762309 2802974 Positive_regulation IL6 TLR7 23824215 2808927 Positive_regulation IL6 TLR7 23824215 2808947 Positive_regulation IL6 TLR7 23867654 839157 Positive_regulation IL6 TLR7 23898332 908487 Positive_regulation IL6 TLR7 23935250 1754413 Positive_regulation IL6 TLR7 23967108 2834494 Positive_regulation IL6 TLR7 24009850 203837 Positive_regulation IL6 TLR7 24178712 3223566 Positive_regulation IL6 TLR7 24191131 1754983 Positive_regulation IL6 TLR7 24191131 1754999 Positive_regulation IL6 TLR7 24205068 2875199 Positive_regulation IL6 TLR7 24205068 2875206 Positive_regulation IL6 TLR7 24224170 184942 Positive_regulation IL6 TLR7 24282429 639160 Positive_regulation IL6 TLR7 24379524 1756166 Positive_regulation IL6 TLR7 24505352 2920697 Positive_regulation IL6 TLR7 24533162 2922440 Positive_regulation IL6 TLR7 24586553 2925448 Positive_regulation IL6 TLR7 24609617 1050571 Positive_regulation IL6 TLR7 24692849 1757911 Positive_regulation IL6 TLR7 24740301 2954633 Positive_regulation IL6 TLR7 24758719 1483074 Positive_regulation IL6 TLR7 24824830 2969477 Positive_regulation IL6 TLR7 24987391 926855 Positive_regulation IL6 TLR7 25071732 927071 Positive_regulation IL6 TLR7 25071732 927072 Positive_regulation IL6 TLR7 25101057 881039 Positive_regulation IL6 TLR7 25112836 1619093 Positive_regulation IL6 TLR7 25136575 197189 Positive_regulation IL6 TLR7 25276832 200405 Positive_regulation IL6 TLR7 25386178 915063 Positive_regulation IL6 TLR7 25541965 3035952 Positive_regulation IL6 TLR7 25550115 1734379 Positive_regulation IL6 TLR7 25550115 1734426 Positive_regulation IL6 TLR7 PMC3194144 134685 Positive_regulation IL6 TLR7 PMC3242235 1702551 Positive_regulation IL6 TNF 10027341 414002 Positive_regulation IL6 TNF 10027341 414003 Positive_regulation IL6 TNF 10190904 1511395 Positive_regulation IL6 TNF 10385526 1247199 Positive_regulation IL6 TNF 10385526 1247209 Positive_regulation IL6 TNF 10385526 1247210 Positive_regulation IL6 TNF 10487610 415296 Positive_regulation IL6 TNF 10931794 789727 Positive_regulation IL6 TNF 11136824 1518265 Positive_regulation IL6 TNF 11136824 1518266 Positive_regulation IL6 TNF 11136824 1518267 Positive_regulation IL6 TNF 11136824 1518268 Positive_regulation IL6 TNF 11136824 1518286 Positive_regulation IL6 TNF 11136824 1518291 Positive_regulation IL6 TNF 11136824 1518296 Positive_regulation IL6 TNF 11136824 1518297 Positive_regulation IL6 TNF 11178114 98209 Positive_regulation IL6 TNF 11263437 418490 Positive_regulation IL6 TNF 11748361 1632822 Positive_regulation IL6 TNF 12417483 791241 Positive_regulation IL6 TNF 12437786 1733982 Positive_regulation IL6 TNF 12718745 99730 Positive_regulation IL6 TNF 12745542 1738308 Positive_regulation IL6 TNF 12745542 1738309 Positive_regulation IL6 TNF 12745542 1738312 Positive_regulation IL6 TNF 12745542 1738313 Positive_regulation IL6 TNF 1311016 1528342 Positive_regulation IL6 TNF 1373292 423498 Positive_regulation IL6 TNF 14562010 423594 Positive_regulation IL6 TNF 14676433 1634290 Positive_regulation IL6 TNF 15121507 792125 Positive_regulation IL6 TNF 1512542 1532293 Positive_regulation IL6 TNF 15574198 3177972 Positive_regulation IL6 TNF 15611291 1534044 Positive_regulation IL6 TNF 15642135 102292 Positive_regulation IL6 TNF 15642135 102296 Positive_regulation IL6 TNF 15642135 102299 Positive_regulation IL6 TNF 15642135 102302 Positive_regulation IL6 TNF 15642148 102412 Positive_regulation IL6 TNF 15642151 102481 Positive_regulation IL6 TNF 1586593 426064 Positive_regulation IL6 TNF 15899029 102746 Positive_regulation IL6 TNF 15899050 103766 Positive_regulation IL6 TNF 16185356 3105671 Positive_regulation IL6 TNF 16185356 3105686 Positive_regulation IL6 TNF 16258194 1740195 Positive_regulation IL6 TNF 16259641 395240 Positive_regulation IL6 TNF 16277680 104694 Positive_regulation IL6 TNF 16277688 104760 Positive_regulation IL6 TNF 1643416 702486 Positive_regulation IL6 TNF 16675414 792631 Positive_regulation IL6 TNF 16684367 105985 Positive_regulation IL6 TNF 16684367 105986 Positive_regulation IL6 TNF 16759367 3225860 Positive_regulation IL6 TNF 16800873 1722655 Positive_regulation IL6 TNF 16803639 106174 Positive_regulation IL6 TNF 16864908 1740380 Positive_regulation IL6 TNF 16899109 106538 Positive_regulation IL6 TNF 16899109 106539 Positive_regulation IL6 TNF 1692079 1542197 Positive_regulation IL6 TNF 17042956 106700 Positive_regulation IL6 TNF 17042956 106701 Positive_regulation IL6 TNF 17042956 106703 Positive_regulation IL6 TNF 17042956 106717 Positive_regulation IL6 TNF 17042956 106718 Positive_regulation IL6 TNF 1717633 1543739 Positive_regulation IL6 TNF 17183659 2373756 Positive_regulation IL6 TNF 17965763 810776 Positive_regulation IL6 TNF 18039391 648962 Positive_regulation IL6 TNF 18046869 1071352 Positive_regulation IL6 TNF 18066067 1951727 Positive_regulation IL6 TNF 18176779 1769624 Positive_regulation IL6 TNF 18410682 110463 Positive_regulation IL6 TNF 18472819 1741831 Positive_regulation IL6 TNF 18472819 1741842 Positive_regulation IL6 TNF 18472926 1743204 Positive_regulation IL6 TNF 18475439 1743663 Positive_regulation IL6 TNF 18475440 1743781 Positive_regulation IL6 TNF 18475475 1743891 Positive_regulation IL6 TNF 18475475 1743892 Positive_regulation IL6 TNF 18475552 1744312 Positive_regulation IL6 TNF 18475559 1744328 Positive_regulation IL6 TNF 18475591 1744503 Positive_regulation IL6 TNF 18475629 1744954 Positive_regulation IL6 TNF 18475738 1745976 Positive_regulation IL6 TNF 18475748 1746328 Positive_regulation IL6 TNF 18475825 1767020 Positive_regulation IL6 TNF 18670628 3041679 Positive_regulation IL6 TNF 18695743 1083728 Positive_regulation IL6 TNF 18822143 143269 Positive_regulation IL6 TNF 1911209 431531 Positive_regulation IL6 TNF 1911209 431584 Positive_regulation IL6 TNF 19116667 2404029 Positive_regulation IL6 TNF 19148295 1746429 Positive_regulation IL6 TNF 19197385 2405269 Positive_regulation IL6 TNF 19226472 112818 Positive_regulation IL6 TNF 19226472 112819 Positive_regulation IL6 TNF 19351711 708256 Positive_regulation IL6 TNF 19476661 3096961 Positive_regulation IL6 TNF 19575800 3109724 Positive_regulation IL6 TNF 19575800 3109727 Positive_regulation IL6 TNF 19575800 3109731 Positive_regulation IL6 TNF 19575800 3109732 Positive_regulation IL6 TNF 19672457 1746656 Positive_regulation IL6 TNF 19686583 116579 Positive_regulation IL6 TNF 19701194 1923914 Positive_regulation IL6 TNF 19707336 175488 Positive_regulation IL6 TNF 19742190 1048191 Positive_regulation IL6 TNF 19745053 2047660 Positive_regulation IL6 TNF 19745053 2047661 Positive_regulation IL6 TNF 19745053 2047662 Positive_regulation IL6 TNF 19851470 175900 Positive_regulation IL6 TNF 19922639 117873 Positive_regulation IL6 TNF 19936089 981575 Positive_regulation IL6 TNF 2007858 1557311 Positive_regulation IL6 TNF 20126618 2439384 Positive_regulation IL6 TNF 20142991 845599 Positive_regulation IL6 TNF 20150970 1213777 Positive_regulation IL6 TNF 20193084 1727974 Positive_regulation IL6 TNF 20205746 1656115 Positive_regulation IL6 TNF 20205746 1656116 Positive_regulation IL6 TNF 20205746 1656117 Positive_regulation IL6 TNF 20205746 1656118 Positive_regulation IL6 TNF 20205746 1656119 Positive_regulation IL6 TNF 20205746 1656120 Positive_regulation IL6 TNF 20205746 1656121 Positive_regulation IL6 TNF 20205746 1656122 Positive_regulation IL6 TNF 20205746 1656123 Positive_regulation IL6 TNF 20205746 1656124 Positive_regulation IL6 TNF 20205746 1656132 Positive_regulation IL6 TNF 20205746 1656133 Positive_regulation IL6 TNF 20205746 1656141 Positive_regulation IL6 TNF 20205746 1656142 Positive_regulation IL6 TNF 20205746 1656143 Positive_regulation IL6 TNF 20205746 1656154 Positive_regulation IL6 TNF 20205746 1656156 Positive_regulation IL6 TNF 20205746 1656157 Positive_regulation IL6 TNF 20205746 1656162 Positive_regulation IL6 TNF 20205746 1656163 Positive_regulation IL6 TNF 2022925 1557590 Positive_regulation IL6 TNF 2022925 1557618 Positive_regulation IL6 TNF 20370892 118627 Positive_regulation IL6 TNF 2039696 434772 Positive_regulation IL6 TNF 20482813 118997 Positive_regulation IL6 TNF 20550728 659624 Positive_regulation IL6 TNF 20808669 1635226 Positive_regulation IL6 TNF 20808962 2473149 Positive_regulation IL6 TNF 20827308 979275 Positive_regulation IL6 TNF 20827308 979292 Positive_regulation IL6 TNF 20830230 1711863 Positive_regulation IL6 TNF 20877569 2475384 Positive_regulation IL6 TNF 20936184 1217177 Positive_regulation IL6 TNF 20953204 11982 Positive_regulation IL6 TNF 20953204 11983 Positive_regulation IL6 TNF 20953204 11984 Positive_regulation IL6 TNF 20953204 11985 Positive_regulation IL6 TNF 20953204 11986 Positive_regulation IL6 TNF 20953204 11987 Positive_regulation IL6 TNF 20953204 11988 Positive_regulation IL6 TNF 20953204 11989 Positive_regulation IL6 TNF 20953204 11990 Positive_regulation IL6 TNF 20953204 11997 Positive_regulation IL6 TNF 20953899 645851 Positive_regulation IL6 TNF 21029292 590579 Positive_regulation IL6 TNF 21029292 590585 Positive_regulation IL6 TNF 21080950 380922 Positive_regulation IL6 TNF 21122092 508298 Positive_regulation IL6 TNF 21122092 508300 Positive_regulation IL6 TNF 21131967 1954741 Positive_regulation IL6 TNF 21152179 1028875 Positive_regulation IL6 TNF 21244650 3099724 Positive_regulation IL6 TNF 21245598 91581 Positive_regulation IL6 TNF 21253481 1748716 Positive_regulation IL6 TNF 21261967 1723437 Positive_regulation IL6 TNF 21276223 508418 Positive_regulation IL6 TNF 21278785 12442 Positive_regulation IL6 TNF 21291387 668411 Positive_regulation IL6 TNF 21294864 121387 Positive_regulation IL6 TNF 21306632 2233027 Positive_regulation IL6 TNF 21394207 2506559 Positive_regulation IL6 TNF 21418620 1697091 Positive_regulation IL6 TNF 21424610 1668502 Positive_regulation IL6 TNF 21445283 3177015 Positive_regulation IL6 TNF 21483750 2512035 Positive_regulation IL6 TNF 21515850 719160 Positive_regulation IL6 TNF 21515850 719163 Positive_regulation IL6 TNF 21629785 2525653 Positive_regulation IL6 TNF 21637744 2525865 Positive_regulation IL6 TNF 21637744 2525925 Positive_regulation IL6 TNF 21679434 379782 Positive_regulation IL6 TNF 21682888 1658617 Positive_regulation IL6 TNF 21687569 661406 Positive_regulation IL6 TNF 21774820 732046 Positive_regulation IL6 TNF 21779146 731304 Positive_regulation IL6 TNF 21810263 1659160 Positive_regulation IL6 TNF 21829352 3052771 Positive_regulation IL6 TNF 2183871 437519 Positive_regulation IL6 TNF 2183871 437597 Positive_regulation IL6 TNF 2183871 437598 Positive_regulation IL6 TNF 2183871 437629 Positive_regulation IL6 TNF 21880146 1863097 Positive_regulation IL6 TNF 21966220 3209120 Positive_regulation IL6 TNF 21966220 3209121 Positive_regulation IL6 TNF 21976971 1136780 Positive_regulation IL6 TNF 21991434 23577 Positive_regulation IL6 TNF 22069489 2569188 Positive_regulation IL6 TNF 22069489 2569234 Positive_regulation IL6 TNF 22072820 1713170 Positive_regulation IL6 TNF 22110478 832187 Positive_regulation IL6 TNF 22115362 212642 Positive_regulation IL6 TNF 22125453 3152138 Positive_regulation IL6 TNF 22132201 2574539 Positive_regulation IL6 TNF 22132201 2574542 Positive_regulation IL6 TNF 22190977 633813 Positive_regulation IL6 TNF 22190977 633814 Positive_regulation IL6 TNF 22190977 633839 Positive_regulation IL6 TNF 22190977 633840 Positive_regulation IL6 TNF 22190977 633847 Positive_regulation IL6 TNF 22190977 633848 Positive_regulation IL6 TNF 22190977 633858 Positive_regulation IL6 TNF 22190977 633859 Positive_regulation IL6 TNF 22190977 633871 Positive_regulation IL6 TNF 22272193 832506 Positive_regulation IL6 TNF 22293775 1886007 Positive_regulation IL6 TNF 22293775 1886011 Positive_regulation IL6 TNF 22348126 2596987 Positive_regulation IL6 TNF 22351606 778144 Positive_regulation IL6 TNF 22351606 778179 Positive_regulation IL6 TNF 22351606 778188 Positive_regulation IL6 TNF 22370853 1140524 Positive_regulation IL6 TNF 22454687 813908 Positive_regulation IL6 TNF 22470484 2614311 Positive_regulation IL6 TNF 22474487 634262 Positive_regulation IL6 TNF 22506098 1680501 Positive_regulation IL6 TNF 22546471 125670 Positive_regulation IL6 TNF 22547990 3152597 Positive_regulation IL6 TNF 22547990 3152607 Positive_regulation IL6 TNF 22550612 2234537 Positive_regulation IL6 TNF 2258696 1568206 Positive_regulation IL6 TNF 22611374 833063 Positive_regulation IL6 TNF 22615828 2643793 Positive_regulation IL6 TNF 22642790 1663031 Positive_regulation IL6 TNF 22642871 1663049 Positive_regulation IL6 TNF 22654787 875808 Positive_regulation IL6 TNF 22660185 518323 Positive_regulation IL6 TNF 22661946 951852 Positive_regulation IL6 TNF 22682420 126129 Positive_regulation IL6 TNF 22723938 2655213 Positive_regulation IL6 TNF 22768286 2660406 Positive_regulation IL6 TNF 22768286 2660437 Positive_regulation IL6 TNF 22816003 2371459 Positive_regulation IL6 TNF 22816003 2371460 Positive_regulation IL6 TNF 22816003 2371466 Positive_regulation IL6 TNF 22816003 2371475 Positive_regulation IL6 TNF 22816003 2371476 Positive_regulation IL6 TNF 22824914 834873 Positive_regulation IL6 TNF 22851816 1750159 Positive_regulation IL6 TNF 22870358 1710352 Positive_regulation IL6 TNF 22891067 903448 Positive_regulation IL6 TNF 22935594 30830 Positive_regulation IL6 TNF 23028407 2219749 Positive_regulation IL6 TNF 23028840 2693187 Positive_regulation IL6 TNF 23028840 2693188 Positive_regulation IL6 TNF 23028840 2693190 Positive_regulation IL6 TNF 23042150 1957910 Positive_regulation IL6 TNF 23049531 904435 Positive_regulation IL6 TNF 23072510 126986 Positive_regulation IL6 TNF 23072510 126991 Positive_regulation IL6 TNF 23072510 126999 Positive_regulation IL6 TNF 2307935 1569749 Positive_regulation IL6 TNF 2307935 1569752 Positive_regulation IL6 TNF 23091492 1072665 Positive_regulation IL6 TNF 23104095 1958293 Positive_regulation IL6 TNF 23104095 1958294 Positive_regulation IL6 TNF 23118903 2712090 Positive_regulation IL6 TNF 23136547 1084289 Positive_regulation IL6 TNF 23136547 1084290 Positive_regulation IL6 TNF 23136554 1060870 Positive_regulation IL6 TNF 23208413 2110589 Positive_regulation IL6 TNF 23236394 2726131 Positive_regulation IL6 TNF 23236394 2726169 Positive_regulation IL6 TNF 23236394 2726175 Positive_regulation IL6 TNF 23240012 2727502 Positive_regulation IL6 TNF 23267346 877761 Positive_regulation IL6 TNF 23271367 1100124 Positive_regulation IL6 TNF 23281897 409356 Positive_regulation IL6 TNF 23285227 2733022 Positive_regulation IL6 TNF 23285227 2733031 Positive_regulation IL6 TNF 23285323 1492777 Positive_regulation IL6 TNF 23335978 2741182 Positive_regulation IL6 TNF 23363614 127888 Positive_regulation IL6 TNF 23363614 127890 Positive_regulation IL6 TNF 23363614 127891 Positive_regulation IL6 TNF 23365595 817125 Positive_regulation IL6 TNF 23365744 97747 Positive_regulation IL6 TNF 23383221 2749529 Positive_regulation IL6 TNF 23401697 637244 Positive_regulation IL6 TNF 23476694 817457 Positive_regulation IL6 TNF 23509435 3154519 Positive_regulation IL6 TNF 23509754 180088 Positive_regulation IL6 TNF 23516523 2768222 Positive_regulation IL6 TNF 23520506 2768954 Positive_regulation IL6 TNF 23527096 2769366 Positive_regulation IL6 TNF 23563706 1962726 Positive_regulation IL6 TNF 23573152 818522 Positive_regulation IL6 TNF 23631691 3215584 Positive_regulation IL6 TNF 23649808 1405114 Positive_regulation IL6 TNF 23649808 1405121 Positive_regulation IL6 TNF 23663457 3113615 Positive_regulation IL6 TNF 23717702 2371924 Positive_regulation IL6 TNF 2373990 1572281 Positive_regulation IL6 TNF 23776651 2805363 Positive_regulation IL6 TNF 23784308 606096 Positive_regulation IL6 TNF 23784308 606110 Positive_regulation IL6 TNF 23784308 606153 Positive_regulation IL6 TNF 23784308 606155 Positive_regulation IL6 TNF 23784308 606158 Positive_regulation IL6 TNF 23784308 606164 Positive_regulation IL6 TNF 23788036 563191 Positive_regulation IL6 TNF 23799152 2807428 Positive_regulation IL6 TNF 23799152 2807456 Positive_regulation IL6 TNF 23799152 2807457 Positive_regulation IL6 TNF 23799152 2807462 Positive_regulation IL6 TNF 23799152 2807466 Positive_regulation IL6 TNF 23835341 727901 Positive_regulation IL6 TNF 23840908 2818806 Positive_regulation IL6 TNF 23840908 2818807 Positive_regulation IL6 TNF 23843796 2119926 Positive_regulation IL6 TNF 23853724 1152203 Positive_regulation IL6 TNF 23864770 1754277 Positive_regulation IL6 TNF 23878415 1754320 Positive_regulation IL6 TNF 23878502 1916094 Positive_regulation IL6 TNF 23901303 1968892 Positive_regulation IL6 TNF 23908975 649284 Positive_regulation IL6 TNF 23922826 2826781 Positive_regulation IL6 TNF 23935933 2828582 Positive_regulation IL6 TNF 23956643 1920756 Positive_regulation IL6 TNF 23967134 2834645 Positive_regulation IL6 TNF 23970974 1154564 Positive_regulation IL6 TNF 23974516 18472 Positive_regulation IL6 TNF 23986795 2220456 Positive_regulation IL6 TNF 23990568 1624260 Positive_regulation IL6 TNF 24015193 2842204 Positive_regulation IL6 TNF 24062615 1628845 Positive_regulation IL6 TNF 24062615 1628893 Positive_regulation IL6 TNF 2406363 1573712 Positive_regulation IL6 TNF 24086143 2350919 Positive_regulation IL6 TNF 24098382 2856012 Positive_regulation IL6 TNF 24098382 2856017 Positive_regulation IL6 TNF 24106699 184497 Positive_regulation IL6 TNF 24116032 2864983 Positive_regulation IL6 TNF 24137500 2867764 Positive_regulation IL6 TNF 24138989 410763 Positive_regulation IL6 TNF 24141610 453549 Positive_regulation IL6 TNF 24171032 638787 Positive_regulation IL6 TNF 24171032 638789 Positive_regulation IL6 TNF 24237643 1728471 Positive_regulation IL6 TNF 24244348 2879475 Positive_regulation IL6 TNF 24244348 2879485 Positive_regulation IL6 TNF 24244348 2879510 Positive_regulation IL6 TNF 24244348 2879511 Positive_regulation IL6 TNF 24244348 2879527 Positive_regulation IL6 TNF 24244348 2879542 Positive_regulation IL6 TNF 24244809 204676 Positive_regulation IL6 TNF 24286116 130163 Positive_regulation IL6 TNF 24289089 131071 Positive_regulation IL6 TNF 24289470 3227944 Positive_regulation IL6 TNF 24303127 2251352 Positive_regulation IL6 TNF 24311895 1755542 Positive_regulation IL6 TNF 24314293 314638 Positive_regulation IL6 TNF 24339952 2894363 Positive_regulation IL6 TNF 24339952 2894380 Positive_regulation IL6 TNF 24339952 2894388 Positive_regulation IL6 TNF 24346288 442642 Positive_regulation IL6 TNF 24346288 442660 Positive_regulation IL6 TNF 24347831 1755872 Positive_regulation IL6 TNF 24348193 3155621 Positive_regulation IL6 TNF 24381940 186046 Positive_regulation IL6 TNF 24381940 186047 Positive_regulation IL6 TNF 24426777 1916712 Positive_regulation IL6 TNF 24426777 1916713 Positive_regulation IL6 TNF 24426777 1916722 Positive_regulation IL6 TNF 24426777 1916723 Positive_regulation IL6 TNF 24426777 1916725 Positive_regulation IL6 TNF 24426777 1916729 Positive_regulation IL6 TNF 24426777 1916730 Positive_regulation IL6 TNF 24426777 1916734 Positive_regulation IL6 TNF 24426777 1916735 Positive_regulation IL6 TNF 24426777 1916736 Positive_regulation IL6 TNF 24426777 1916738 Positive_regulation IL6 TNF 24434316 1045859 Positive_regulation IL6 TNF 24455420 1152545 Positive_regulation IL6 TNF 24466027 2912135 Positive_regulation IL6 TNF 24471106 3077387 Positive_regulation IL6 TNF 24479486 1667593 Positive_regulation IL6 TNF 24479486 1667594 Positive_regulation IL6 TNF 24489848 2916454 Positive_regulation IL6 TNF 24489848 2916473 Positive_regulation IL6 TNF 24491163 380492 Positive_regulation IL6 TNF 24519204 653618 Positive_regulation IL6 TNF 24563869 1495680 Positive_regulation IL6 TNF 24563869 1495683 Positive_regulation IL6 TNF 24563869 1495684 Positive_regulation IL6 TNF 24586810 2927090 Positive_regulation IL6 TNF 24586810 2927092 Positive_regulation IL6 TNF 24603712 2931988 Positive_regulation IL6 TNF 24624094 964457 Positive_regulation IL6 TNF 24642694 2935185 Positive_regulation IL6 TNF 24647690 2936311 Positive_regulation IL6 TNF 24648797 1712215 Positive_regulation IL6 TNF 24659862 1757640 Positive_regulation IL6 TNF 24659862 1757830 Positive_regulation IL6 TNF 24661782 368187 Positive_regulation IL6 TNF 24669186 742965 Positive_regulation IL6 TNF 24683547 187714 Positive_regulation IL6 TNF 24705157 984790 Positive_regulation IL6 TNF 24705157 984844 Positive_regulation IL6 TNF 24758719 1483070 Positive_regulation IL6 TNF 24758719 1483071 Positive_regulation IL6 TNF 24758719 1483072 Positive_regulation IL6 TNF 24758719 1483073 Positive_regulation IL6 TNF 24758719 1483135 Positive_regulation IL6 TNF 24758719 1483136 Positive_regulation IL6 TNF 24758719 1483137 Positive_regulation IL6 TNF 24758719 1483143 Positive_regulation IL6 TNF 24758719 1483144 Positive_regulation IL6 TNF 24758719 1483145 Positive_regulation IL6 TNF 24758719 1483160 Positive_regulation IL6 TNF 24758719 1483175 Positive_regulation IL6 TNF 24762063 401047 Positive_regulation IL6 TNF 24852285 2972952 Positive_regulation IL6 TNF 24885494 396636 Positive_regulation IL6 TNF 24887434 132701 Positive_regulation IL6 TNF 24936153 1627922 Positive_regulation IL6 TNF 24944768 2115572 Positive_regulation IL6 TNF 24945146 2980868 Positive_regulation IL6 TNF 24957270 1702191 Positive_regulation IL6 TNF 24971321 193312 Positive_regulation IL6 TNF 2499653 1577001 Positive_regulation IL6 TNF 2499657 1577009 Positive_regulation IL6 TNF 2499657 1577011 Positive_regulation IL6 TNF 24999379 2229500 Positive_regulation IL6 TNF 25017038 1087520 Positive_regulation IL6 TNF 25019059 948429 Positive_regulation IL6 TNF 25026958 1668339 Positive_regulation IL6 TNF 25026958 1668340 Positive_regulation IL6 TNF 25104881 1760307 Positive_regulation IL6 TNF 25123797 368563 Positive_regulation IL6 TNF 25127062 2998159 Positive_regulation IL6 TNF 25143751 645499 Positive_regulation IL6 TNF 25198511 3006087 Positive_regulation IL6 TNF 25229347 3007950 Positive_regulation IL6 TNF 25229347 3007951 Positive_regulation IL6 TNF 25229347 3007961 Positive_regulation IL6 TNF 25229347 3007962 Positive_regulation IL6 TNF 25239871 32263 Positive_regulation IL6 TNF 25250322 199952 Positive_regulation IL6 TNF 25289073 845244 Positive_regulation IL6 TNF 25343247 3019006 Positive_regulation IL6 TNF 25409436 3028679 Positive_regulation IL6 TNF 25479074 1135576 Positive_regulation IL6 TNF 25501329 1135634 Positive_regulation IL6 TNF 25506235 1629231 Positive_regulation IL6 TNF 25538747 2007481 Positive_regulation IL6 TNF 25566463 1498521 Positive_regulation IL6 TNF 25614712 1763568 Positive_regulation IL6 TNF 2642531 1577578 Positive_regulation IL6 TNF 2659724 1577667 Positive_regulation IL6 TNF 2769183 1577892 Positive_regulation IL6 TNF 2783334 1577906 Positive_regulation IL6 TNF 2785398 442934 Positive_regulation IL6 TNF 2803928 443155 Positive_regulation IL6 TNF 2833558 1578546 Positive_regulation IL6 TNF 3049617 1425494 Positive_regulation IL6 TNF 3049617 1425495 Positive_regulation IL6 TNF 3049617 1425602 Positive_regulation IL6 TNF 3049617 1425603 Positive_regulation IL6 TNF 3110354 1580065 Positive_regulation IL6 TNF 3137305 1580378 Positive_regulation IL6 TNF 3143799 1580433 Positive_regulation IL6 TNF 3290384 1580799 Positive_regulation IL6 TNF 3309124 1580918 Positive_regulation IL6 TNF 3309124 1580972 Positive_regulation IL6 TNF 3316469 1581032 Positive_regulation IL6 TNF 3411293 1581198 Positive_regulation IL6 TNF 3435706 443513 Positive_regulation IL6 TNF 3491174 1583105 Positive_regulation IL6 TNF 3494807 1583279 Positive_regulation IL6 TNF 3494807 1583280 Positive_regulation IL6 TNF 3494807 1583343 Positive_regulation IL6 TNF 3572302 1583481 Positive_regulation IL6 TNF 3598461 1583540 Positive_regulation IL6 TNF 3598461 1583574 Positive_regulation IL6 TNF 3819645 1583716 Positive_regulation IL6 TNF 7530764 1589990 Positive_regulation IL6 TNF 7577463 444045 Positive_regulation IL6 TNF 7595192 1590716 Positive_regulation IL6 TNF 7629516 1591292 Positive_regulation IL6 TNF 7929565 1443623 Positive_regulation IL6 TNF 8145042 1594267 Positive_regulation IL6 TNF 8381656 444840 Positive_regulation IL6 TNF 8426121 1595208 Positive_regulation IL6 TNF 8478614 1595558 Positive_regulation IL6 TNF 8551238 1595904 Positive_regulation IL6 TNF 8551238 1595905 Positive_regulation IL6 TNF 8551238 1595907 Positive_regulation IL6 TNF 9271590 1601626 Positive_regulation IL6 TNF 9400742 797439 Positive_regulation IL6 TNF 9788898 798142 Positive_regulation IL6 TNF 9788898 798143 Positive_regulation IL6 TNF 9814601 702740 Positive_regulation IL6 TNF 9864375 1473484 Positive_regulation IL6 TNF PMC2188223 1605407 Positive_regulation IL6 TNF PMC2834114 134582 Positive_regulation IL6 TNF PMC2834114 134586 Positive_regulation IL6 TNF PMC3301465 660976 Positive_regulation IL6 TNF PMC3952452 2236257 Positive_regulation IL6 TNF PMC4033969 2245916 Positive_regulation IL6 TNF PMC4212306 3206485 Positive_regulation IL6 TP63 23945602 1729992 Positive_regulation IL6R IL6 24501689 2163026 Positive_regulation IL6R IL6ST 22421340 1718692 Positive_regulation IL6R IL6ST 24710148 986028 Positive_regulation IL6R JAK1 24467886 474309 Positive_regulation IL6R JAK2 24467886 474310 Positive_regulation IL6R JAK3 24467886 474311 Positive_regulation IL6R MYLIP 22942733 1097142 Positive_regulation IL6R TREX1 19787081 981277 Positive_regulation IL6R TREX1 24312573 2889867 Positive_regulation IL6R VAV2 23935450 2283771 Positive_regulation IL6R VAV3 23935450 2283772 Positive_regulation IL6ST EPHB2 24643025 2935560 Positive_regulation IL6ST FAS 23056264 2700758 Positive_regulation IL6ST FAS 23056264 2700766 Positive_regulation IL6ST IL6R 23995732 1929403 Positive_regulation IL6ST MUC16 22132309 1680448 Positive_regulation IL6ST STAT4 24058793 1705879 Positive_regulation IL6ST STAT4 25259790 3010649 Positive_regulation IL6ST STAT4 25259790 3010677 Positive_regulation IL6ST TNF 24244348 2879529 Positive_regulation IL6ST TNF 24244348 2879531 Positive_regulation IL7 CD14 25025695 2989358 Positive_regulation IL7 FAS 22194871 2583062 Positive_regulation IL7 FAS 22194871 2583063 Positive_regulation IL7 FAS 22194871 2583067 Positive_regulation IL7 FAS 22194871 2583068 Positive_regulation IL7 FAS 22194871 2583075 Positive_regulation IL7 FOXO1 15353558 1533361 Positive_regulation IL7 FOXO1 18978794 1951882 Positive_regulation IL7 FOXO1 22363451 2599158 Positive_regulation IL7 FOXO1 22654881 901223 Positive_regulation IL7 FOXO1 24324706 2891131 Positive_regulation IL7 LBP 25025695 2989359 Positive_regulation IL7 TLR7 11686880 3103296 Positive_regulation IL7 TLR7 24740301 2954629 Positive_regulation IL7 TNF 1311016 1528343 Positive_regulation IL7 TNF 1586593 426065 Positive_regulation IL7 TNF 16356195 104881 Positive_regulation IL7 TNF 1643416 702487 Positive_regulation IL7 TNF 1692079 1542199 Positive_regulation IL7 TNF 1717633 1543740 Positive_regulation IL7 TNF 18475440 1743782 Positive_regulation IL7 TNF 1911209 431585 Positive_regulation IL7 TNF 19742190 1048192 Positive_regulation IL7 TNF 19936089 981577 Positive_regulation IL7 TNF 2007858 1557252 Positive_regulation IL7 TNF 2007858 1557313 Positive_regulation IL7 TNF 2022925 1557591 Positive_regulation IL7 TNF 2022925 1557619 Positive_regulation IL7 TNF 2039696 434773 Positive_regulation IL7 TNF 20808962 2473150 Positive_regulation IL7 TNF 21829352 3052803 Positive_regulation IL7 TNF 2183871 437520 Positive_regulation IL7 TNF 2183871 437599 Positive_regulation IL7 TNF 2183871 437600 Positive_regulation IL7 TNF 2183871 437630 Positive_regulation IL7 TNF 2258696 1568207 Positive_regulation IL7 TNF 23136547 1084293 Positive_regulation IL7 TNF 23576878 1628506 Positive_regulation IL7 TNF 2373990 1572282 Positive_regulation IL7 TNF 2406363 1573713 Positive_regulation IL7 TNF 24339952 2894365 Positive_regulation IL7 TNF 24562309 1959955 Positive_regulation IL7 TNF 2499653 1577002 Positive_regulation IL7 TNF 2642531 1577579 Positive_regulation IL7 TNF 2659724 1577668 Positive_regulation IL7 TNF 2769183 1577893 Positive_regulation IL7 TNF 2785398 442935 Positive_regulation IL7 TNF 2803928 443156 Positive_regulation IL7 TNF 2833558 1578547 Positive_regulation IL7 TNF 3049617 1425496 Positive_regulation IL7 TNF 3049617 1425497 Positive_regulation IL7 TNF 3049617 1425604 Positive_regulation IL7 TNF 3049617 1425605 Positive_regulation IL7 TNF 3110354 1580066 Positive_regulation IL7 TNF 3137305 1580379 Positive_regulation IL7 TNF 3143799 1580434 Positive_regulation IL7 TNF 3290384 1580800 Positive_regulation IL7 TNF 3309124 1580919 Positive_regulation IL7 TNF 3309124 1580973 Positive_regulation IL7 TNF 3316469 1581033 Positive_regulation IL7 TNF 3411293 1581199 Positive_regulation IL7 TNF 3435706 443514 Positive_regulation IL7 TNF 3491174 1583106 Positive_regulation IL7 TNF 3494807 1583281 Positive_regulation IL7 TNF 3494807 1583282 Positive_regulation IL7 TNF 3494807 1583344 Positive_regulation IL7 TNF 3572302 1583482 Positive_regulation IL7 TNF 3598461 1583541 Positive_regulation IL7 TNF 3598461 1583575 Positive_regulation IL7 TNF 3819645 1583717 Positive_regulation IL7 TNF 8426121 1595209 Positive_regulation IL7 TNF 8478614 1595559 Positive_regulation IL7 TNF 9652754 447278 Positive_regulation IL7 TNF PMC2188223 1605408 Positive_regulation IL7R FAS 19011158 1051111 Positive_regulation IL7R MAML3 19349467 1554425 Positive_regulation IL7R MAML3 19349467 1554477 Positive_regulation IL8 ANGPT1 18320019 1212562 Positive_regulation IL8 ANGPT1 24563688 2923990 Positive_regulation IL8 ANGPT1 24563688 2924010 Positive_regulation IL8 ANO1 22973054 1807584 Positive_regulation IL8 CCND1 24086675 2855502 Positive_regulation IL8 CD14 10449523 1512268 Positive_regulation IL8 CD14 17242961 810084 Positive_regulation IL8 CD14 17242961 810102 Positive_regulation IL8 CD14 17242961 810103 Positive_regulation IL8 CD14 21352551 1626321 Positive_regulation IL8 CD14 21994762 3220191 Positive_regulation IL8 CD14 22518341 1082540 Positive_regulation IL8 CD14 25025695 2989360 Positive_regulation IL8 CHI3L1 22056877 2144449 Positive_regulation IL8 CHI3L1 22056877 2144450 Positive_regulation IL8 CHI3L1 22056877 2144454 Positive_regulation IL8 CHI3L1 23388501 1920504 Positive_regulation IL8 CHI3L1 23755018 961419 Positive_regulation IL8 CHI3L1 24729664 1758063 Positive_regulation IL8 CHI3L1 24729664 1758080 Positive_regulation IL8 CHI3L1 25358394 1946498 Positive_regulation IL8 EPHB2 16164755 3105666 Positive_regulation IL8 EPHB2 19025606 1646437 Positive_regulation IL8 EPHB2 19133134 1625204 Positive_regulation IL8 EPHB2 20529221 34789 Positive_regulation IL8 EPHB2 21130993 139226 Positive_regulation IL8 EPHB2 21192810 366203 Positive_regulation IL8 EPHB2 21192810 366204 Positive_regulation IL8 EPHB2 21192810 366206 Positive_regulation IL8 EPHB2 21451502 1918305 Positive_regulation IL8 EPHB2 21451502 1918328 Positive_regulation IL8 EPHB2 21599982 527412 Positive_regulation IL8 EPHB2 21599982 527507 Positive_regulation IL8 EPHB2 21789185 2537980 Positive_regulation IL8 EPHB2 21860608 1038265 Positive_regulation IL8 EPHB2 22867088 2233233 Positive_regulation IL8 EPHB2 22867088 2233315 Positive_regulation IL8 EPHB2 23029099 2695233 Positive_regulation IL8 EPHB2 23401699 637249 Positive_regulation IL8 EPHB2 23945675 2118006 Positive_regulation IL8 EPHB2 24587311 2929286 Positive_regulation IL8 EPHB2 24647471 2936140 Positive_regulation IL8 EPHB2 25121739 2997346 Positive_regulation IL8 EPHB2 25398056 3027498 Positive_regulation IL8 F2R 16696869 279163 Positive_regulation IL8 F2R 17480240 279750 Positive_regulation IL8 F2R 21760880 2535467 Positive_regulation IL8 F2R 21941675 1082274 Positive_regulation IL8 FAS 15289496 1311359 Positive_regulation IL8 FAS 15289496 1311367 Positive_regulation IL8 FAS 17971210 3108463 Positive_regulation IL8 FAS 20454998 1668921 Positive_regulation IL8 FAS 21120077 1046263 Positive_regulation IL8 FAS 23967134 2834579 Positive_regulation IL8 FAS 23967134 2834601 Positive_regulation IL8 FAS 23967134 2834606 Positive_regulation IL8 FAS 23967134 2834608 Positive_regulation IL8 FAS 23967134 2834652 Positive_regulation IL8 FAS 25278779 1478815 Positive_regulation IL8 HBEGF 24555532 3114320 Positive_regulation IL8 IL1B 16126496 1049564 Positive_regulation IL8 IL1B 18472850 1742280 Positive_regulation IL8 IL1B 18553155 3090089 Positive_regulation IL8 IL1B 21176181 3099683 Positive_regulation IL8 IL1B 23977375 2840172 Positive_regulation IL8 IL1B 24489848 2916457 Positive_regulation IL8 IL1B 24618842 2933387 Positive_regulation IL8 IL1B 25530684 1763485 Positive_regulation IL8 IL1B 25530684 1763486 Positive_regulation IL8 IL1B 9400742 797441 Positive_regulation IL8 ITGAL 23379382 412361 Positive_regulation IL8 ITGB2 1708813 1543170 Positive_regulation IL8 ITGB2 18472819 1741834 Positive_regulation IL8 ITGB2 1969919 1555842 Positive_regulation IL8 ITGB2 7722453 1592031 Positive_regulation IL8 ITGB2 7744962 1440115 Positive_regulation IL8 ITGB2 8270858 1594760 Positive_regulation IL8 ITGB2 8340753 1594924 Positive_regulation IL8 ITGB2 8691134 1598409 Positive_regulation IL8 ITGB2 8769427 1455875 Positive_regulation IL8 LBP 21352551 1626325 Positive_regulation IL8 LBP 21352551 1626327 Positive_regulation IL8 LBP 25025695 2989361 Positive_regulation IL8 LINC00284 25431574 918400 Positive_regulation IL8 LINC00341 25431574 918360 Positive_regulation IL8 MAP2K6 24598028 272051 Positive_regulation IL8 MIP 20846396 353597 Positive_regulation IL8 MIP 20846396 353604 Positive_regulation IL8 MIP 21687657 2528760 Positive_regulation IL8 MIP 21931324 1720403 Positive_regulation IL8 MIP 25006230 1733065 Positive_regulation IL8 MMP7 23941552 1507117 Positive_regulation IL8 MUC16 9041687 3230189 Positive_regulation IL8 PGC 25367151 133802 Positive_regulation IL8 RCAN1 19348862 158339 Positive_regulation IL8 RCAN1 19819266 158536 Positive_regulation IL8 RCAN1 19819266 158537 Positive_regulation IL8 RCAN1 19819266 158554 Positive_regulation IL8 RCAN1 19819266 158570 Positive_regulation IL8 S100A7 22230654 3112894 Positive_regulation IL8 S100A7 22230654 3112896 Positive_regulation IL8 TLR7 11686880 3103306 Positive_regulation IL8 TLR7 18053251 3212100 Positive_regulation IL8 TLR7 19527497 3109675 Positive_regulation IL8 TLR7 19745516 1624067 Positive_regulation IL8 TLR7 20383325 2445826 Positive_regulation IL8 TLR7 20505832 2451758 Positive_regulation IL8 TLR7 20584912 1377119 Positive_regulation IL8 TLR7 20617179 3047883 Positive_regulation IL8 TLR7 20948655 846420 Positive_regulation IL8 TLR7 21108806 1626199 Positive_regulation IL8 TLR7 21556316 1078213 Positive_regulation IL8 TLR7 22218461 1086232 Positive_regulation IL8 TLR7 22513098 125475 Positive_regulation IL8 TLR7 22558189 2624563 Positive_regulation IL8 TLR7 22726246 3214734 Positive_regulation IL8 TLR7 23061052 863736 Positive_regulation IL8 TLR7 23298379 366929 Positive_regulation IL8 TLR7 23483986 2764934 Positive_regulation IL8 TLR7 23824215 2808937 Positive_regulation IL8 TLR7 23824215 2808957 Positive_regulation IL8 TLR7 24164922 399417 Positive_regulation IL8 TLR7 24164922 399439 Positive_regulation IL8 TLR7 24164922 399471 Positive_regulation IL8 TLR7 24285369 3138868 Positive_regulation IL8 TLR7 24498214 2918988 Positive_regulation IL8 TLR7 24847326 912680 Positive_regulation IL8 TLR7 24886274 357585 Positive_regulation IL8 TLR7 25071732 926978 Positive_regulation IL8 TLR7 25071732 927082 Positive_regulation IL8 TLR7 25089120 1627983 Positive_regulation IL8 TLR7 25089120 1627984 Positive_regulation IL8 TLR7 25136336 927191 Positive_regulation IL8 TLR7 25161655 913901 Positive_regulation IL8 TLR7 25276832 200415 Positive_regulation IL8 TLR7 25595212 3211339 Positive_regulation IL8 TLR7 PMC3194144 134696 Positive_regulation IL8 TNF 11178114 98210 Positive_regulation IL8 TNF 11686888 3103511 Positive_regulation IL8 TNF 11879548 98692 Positive_regulation IL8 TNF 12377104 316931 Positive_regulation IL8 TNF 12718745 99732 Positive_regulation IL8 TNF 1311016 1528344 Positive_regulation IL8 TNF 14651748 3095618 Positive_regulation IL8 TNF 15642151 102482 Positive_regulation IL8 TNF 15826301 224734 Positive_regulation IL8 TNF 15857511 648855 Positive_regulation IL8 TNF 15857511 648870 Positive_regulation IL8 TNF 1586593 426066 Positive_regulation IL8 TNF 16091140 1624747 Positive_regulation IL8 TNF 16091140 1624762 Positive_regulation IL8 TNF 16185356 3105672 Positive_regulation IL8 TNF 16185356 3105673 Positive_regulation IL8 TNF 16185356 3105688 Positive_regulation IL8 TNF 16191192 318561 Positive_regulation IL8 TNF 16259055 3230767 Positive_regulation IL8 TNF 16356198 104896 Positive_regulation IL8 TNF 1643416 702488 Positive_regulation IL8 TNF 16759367 3225862 Positive_regulation IL8 TNF 16846531 106208 Positive_regulation IL8 TNF 16864907 1740340 Positive_regulation IL8 TNF 16864908 1740381 Positive_regulation IL8 TNF 16864908 1740382 Positive_regulation IL8 TNF 1692079 1542200 Positive_regulation IL8 TNF 1717633 1543741 Positive_regulation IL8 TNF 17183659 2373757 Positive_regulation IL8 TNF 17342240 810707 Positive_regulation IL8 TNF 17388785 590489 Positive_regulation IL8 TNF 17388785 590490 Positive_regulation IL8 TNF 17620405 1341828 Positive_regulation IL8 TNF 17620405 1341833 Positive_regulation IL8 TNF 17620405 1341845 Positive_regulation IL8 TNF 18289377 2112395 Positive_regulation IL8 TNF 18321393 356784 Positive_regulation IL8 TNF 18405381 352156 Positive_regulation IL8 TNF 18410682 110366 Positive_regulation IL8 TNF 18410682 110436 Positive_regulation IL8 TNF 18410682 110464 Positive_regulation IL8 TNF 18472819 1741832 Positive_regulation IL8 TNF 18472819 1741843 Positive_regulation IL8 TNF 18472842 1742218 Positive_regulation IL8 TNF 18475440 1743783 Positive_regulation IL8 TNF 18475491 1744038 Positive_regulation IL8 TNF 18475637 1745102 Positive_regulation IL8 TNF 18475680 1745381 Positive_regulation IL8 TNF 18475682 1745394 Positive_regulation IL8 TNF 18475720 1745582 Positive_regulation IL8 TNF 18475720 1745584 Positive_regulation IL8 TNF 18475727 1745859 Positive_regulation IL8 TNF 18475727 1745895 Positive_regulation IL8 TNF 18475825 1767021 Positive_regulation IL8 TNF 18556683 1035462 Positive_regulation IL8 TNF 19014534 2232737 Positive_regulation IL8 TNF 19014534 2232738 Positive_regulation IL8 TNF 19014534 2232739 Positive_regulation IL8 TNF 19014534 2232783 Positive_regulation IL8 TNF 19014534 2232786 Positive_regulation IL8 TNF 1911209 431586 Positive_regulation IL8 TNF 19281072 1071665 Positive_regulation IL8 TNF 19308690 495329 Positive_regulation IL8 TNF 19434244 646262 Positive_regulation IL8 TNF 19442267 1696280 Positive_regulation IL8 TNF 19487419 1554843 Positive_regulation IL8 TNF 19575800 3109733 Positive_regulation IL8 TNF 19621073 2370522 Positive_regulation IL8 TNF 1969919 1555846 Positive_regulation IL8 TNF 19707336 175489 Positive_regulation IL8 TNF 19709445 1625549 Positive_regulation IL8 TNF 19709445 1625559 Positive_regulation IL8 TNF 19709445 1625560 Positive_regulation IL8 TNF 19718408 3231703 Positive_regulation IL8 TNF 19742190 1048193 Positive_regulation IL8 TNF 19788749 3110062 Positive_regulation IL8 TNF 19847291 2429188 Positive_regulation IL8 TNF 19847291 2429217 Positive_regulation IL8 TNF 19936089 981579 Positive_regulation IL8 TNF 20069129 1213491 Positive_regulation IL8 TNF 20069129 1213496 Positive_regulation IL8 TNF 2007858 1557314 Positive_regulation IL8 TNF 20126618 2439385 Positive_regulation IL8 TNF 20139906 9439 Positive_regulation IL8 TNF 20158898 1696599 Positive_regulation IL8 TNF 20161853 1043923 Positive_regulation IL8 TNF 2022925 1557592 Positive_regulation IL8 TNF 2022925 1557620 Positive_regulation IL8 TNF 2039696 434774 Positive_regulation IL8 TNF 20454998 1668918 Positive_regulation IL8 TNF 20454998 1668920 Positive_regulation IL8 TNF 20508788 1710314 Positive_regulation IL8 TNF 20626862 3110846 Positive_regulation IL8 TNF 20803037 3175155 Positive_regulation IL8 TNF 20808962 2473151 Positive_regulation IL8 TNF 20830230 1711865 Positive_regulation IL8 TNF 20936184 1217176 Positive_regulation IL8 TNF 20936184 1217178 Positive_regulation IL8 TNF 20936184 1217179 Positive_regulation IL8 TNF 21188217 1081639 Positive_regulation IL8 TNF 21261967 1723438 Positive_regulation IL8 TNF 21295490 3157825 Positive_regulation IL8 TNF 21306441 1889364 Positive_regulation IL8 TNF 21451502 1918304 Positive_regulation IL8 TNF 21468084 12594 Positive_regulation IL8 TNF 21494373 1037918 Positive_regulation IL8 TNF 21496221 229357 Positive_regulation IL8 TNF 21496221 229359 Positive_regulation IL8 TNF 21686188 1091117 Positive_regulation IL8 TNF 21765616 1749298 Positive_regulation IL8 TNF 21829352 3052808 Positive_regulation IL8 TNF 2183871 437521 Positive_regulation IL8 TNF 2183871 437601 Positive_regulation IL8 TNF 2183871 437602 Positive_regulation IL8 TNF 2183871 437631 Positive_regulation IL8 TNF 21906391 508609 Positive_regulation IL8 TNF 21931826 2554970 Positive_regulation IL8 TNF 21949653 3053473 Positive_regulation IL8 TNF 21976971 1136781 Positive_regulation IL8 TNF 22032685 3112846 Positive_regulation IL8 TNF 22069653 3183321 Positive_regulation IL8 TNF 22072820 1713172 Positive_regulation IL8 TNF 22096348 1628251 Positive_regulation IL8 TNF 22203854 1155982 Positive_regulation IL8 TNF 22235301 2585775 Positive_regulation IL8 TNF 22235381 1082470 Positive_regulation IL8 TNF 22235381 1082471 Positive_regulation IL8 TNF 22235381 1082472 Positive_regulation IL8 TNF 22235381 1082473 Positive_regulation IL8 TNF 22235381 1082479 Positive_regulation IL8 TNF 22235381 1082480 Positive_regulation IL8 TNF 22254077 2116091 Positive_regulation IL8 TNF 22291719 1156030 Positive_regulation IL8 TNF 22414102 682235 Positive_regulation IL8 TNF 22414102 682237 Positive_regulation IL8 TNF 22479607 2616272 Positive_regulation IL8 TNF 22506098 1680503 Positive_regulation IL8 TNF 22534338 398568 Positive_regulation IL8 TNF 22577250 1749930 Positive_regulation IL8 TNF 2258696 1568208 Positive_regulation IL8 TNF 22727020 1663595 Positive_regulation IL8 TNF 22761877 2659060 Positive_regulation IL8 TNF 22768286 2660407 Positive_regulation IL8 TNF 22768286 2660438 Positive_regulation IL8 TNF 22815893 2666604 Positive_regulation IL8 TNF 22891766 245228 Positive_regulation IL8 TNF 22891766 245229 Positive_regulation IL8 TNF 22899878 1750206 Positive_regulation IL8 TNF 22924051 636874 Positive_regulation IL8 TNF 22988345 1750568 Positive_regulation IL8 TNF 23065264 1832229 Positive_regulation IL8 TNF 23251142 3076084 Positive_regulation IL8 TNF 23326019 1751328 Positive_regulation IL8 TNF 23328126 725585 Positive_regulation IL8 TNF 23354937 1624060 Positive_regulation IL8 TNF 23403612 843010 Positive_regulation IL8 TNF 23516523 2768229 Positive_regulation IL8 TNF 23533479 817805 Positive_regulation IL8 TNF 23557437 2233522 Positive_regulation IL8 TNF 23557437 2233523 Positive_regulation IL8 TNF 23637609 3060926 Positive_regulation IL8 TNF 23637609 3060937 Positive_regulation IL8 TNF 23637609 3060940 Positive_regulation IL8 TNF 23637609 3060941 Positive_regulation IL8 TNF 2373990 1572283 Positive_regulation IL8 TNF 23800251 1627032 Positive_regulation IL8 TNF 23800251 1627033 Positive_regulation IL8 TNF 23800251 1627034 Positive_regulation IL8 TNF 23800251 1627079 Positive_regulation IL8 TNF 23800251 1627141 Positive_regulation IL8 TNF 23835341 727905 Positive_regulation IL8 TNF 23841502 367164 Positive_regulation IL8 TNF 23841502 367165 Positive_regulation IL8 TNF 23841502 367169 Positive_regulation IL8 TNF 23841502 367170 Positive_regulation IL8 TNF 23841502 367172 Positive_regulation IL8 TNF 23841502 367173 Positive_regulation IL8 TNF 23841502 367174 Positive_regulation IL8 TNF 23878502 1916099 Positive_regulation IL8 TNF 23935691 822184 Positive_regulation IL8 TNF 23935691 822194 Positive_regulation IL8 TNF 23935691 822211 Positive_regulation IL8 TNF 23935933 2828566 Positive_regulation IL8 TNF 23935933 2828569 Positive_regulation IL8 TNF 23935933 2828583 Positive_regulation IL8 TNF 23940786 2832444 Positive_regulation IL8 TNF 23967134 2834575 Positive_regulation IL8 TNF 23967134 2834576 Positive_regulation IL8 TNF 23967134 2834577 Positive_regulation IL8 TNF 23967134 2834578 Positive_regulation IL8 TNF 23967134 2834599 Positive_regulation IL8 TNF 23967134 2834600 Positive_regulation IL8 TNF 23967134 2834605 Positive_regulation IL8 TNF 23967134 2834620 Positive_regulation IL8 TNF 23967134 2834621 Positive_regulation IL8 TNF 23967134 2834636 Positive_regulation IL8 TNF 23967134 2834641 Positive_regulation IL8 TNF 23967134 2834646 Positive_regulation IL8 TNF 23967134 2834651 Positive_regulation IL8 TNF 23967134 2834653 Positive_regulation IL8 TNF 23967134 2834654 Positive_regulation IL8 TNF 23974516 18473 Positive_regulation IL8 TNF 24030221 623344 Positive_regulation IL8 TNF 24030221 623347 Positive_regulation IL8 TNF 24030221 623348 Positive_regulation IL8 TNF 24030221 623351 Positive_regulation IL8 TNF 24030221 623352 Positive_regulation IL8 TNF 2406363 1573714 Positive_regulation IL8 TNF 24086143 2350908 Positive_regulation IL8 TNF 24098801 2864936 Positive_regulation IL8 TNF 24156363 2233552 Positive_regulation IL8 TNF 24289089 131072 Positive_regulation IL8 TNF 24311895 1755543 Positive_regulation IL8 TNF 24318398 697087 Positive_regulation IL8 TNF 24348661 1714028 Positive_regulation IL8 TNF 24349530 2898416 Positive_regulation IL8 TNF 24349530 2898425 Positive_regulation IL8 TNF 24349530 2898428 Positive_regulation IL8 TNF 24349530 2898429 Positive_regulation IL8 TNF 24349530 2898438 Positive_regulation IL8 TNF 24349530 2898445 Positive_regulation IL8 TNF 24385684 1756436 Positive_regulation IL8 TNF 24454477 639507 Positive_regulation IL8 TNF 24455739 186399 Positive_regulation IL8 TNF 24455739 186400 Positive_regulation IL8 TNF 24455739 186401 Positive_regulation IL8 TNF 24455739 186402 Positive_regulation IL8 TNF 24455739 186403 Positive_regulation IL8 TNF 24455739 186404 Positive_regulation IL8 TNF 24455739 186406 Positive_regulation IL8 TNF 24455739 186407 Positive_regulation IL8 TNF 24476550 1651482 Positive_regulation IL8 TNF 24489848 2916456 Positive_regulation IL8 TNF 24499192 367807 Positive_regulation IL8 TNF 24499192 367813 Positive_regulation IL8 TNF 24516470 696968 Positive_regulation IL8 TNF 24517278 131757 Positive_regulation IL8 TNF 24517278 131758 Positive_regulation IL8 TNF 24517278 131759 Positive_regulation IL8 TNF 24517278 131836 Positive_regulation IL8 TNF 24517278 131853 Positive_regulation IL8 TNF 24517278 131873 Positive_regulation IL8 TNF 24517278 131886 Positive_regulation IL8 TNF 24551209 2923348 Positive_regulation IL8 TNF 24586678 2926126 Positive_regulation IL8 TNF 24586752 2926275 Positive_regulation IL8 TNF 24586752 2926282 Positive_regulation IL8 TNF 24586752 2926291 Positive_regulation IL8 TNF 24586752 2926299 Positive_regulation IL8 TNF 24646914 1125075 Positive_regulation IL8 TNF 24669186 742966 Positive_regulation IL8 TNF 24830946 2970372 Positive_regulation IL8 TNF 24830946 2970373 Positive_regulation IL8 TNF 24830946 2970402 Positive_regulation IL8 TNF 24864134 1758816 Positive_regulation IL8 TNF 24864134 1758817 Positive_regulation IL8 TNF 24864134 1758818 Positive_regulation IL8 TNF 24864134 1758822 Positive_regulation IL8 TNF 24864134 1758824 Positive_regulation IL8 TNF 24864134 1758828 Positive_regulation IL8 TNF 24864134 1758832 Positive_regulation IL8 TNF 24864134 1758834 Positive_regulation IL8 TNF 24864134 1758837 Positive_regulation IL8 TNF 24864134 1758838 Positive_regulation IL8 TNF 24901008 1621680 Positive_regulation IL8 TNF 24901008 1621687 Positive_regulation IL8 TNF 24920275 2213777 Positive_regulation IL8 TNF 24936153 1627918 Positive_regulation IL8 TNF 24945146 2980875 Positive_regulation IL8 TNF 24989059 368512 Positive_regulation IL8 TNF 2499653 1577003 Positive_regulation IL8 TNF 25013674 1143398 Positive_regulation IL8 TNF 25015002 357672 Positive_regulation IL8 TNF 25015002 357679 Positive_regulation IL8 TNF 25037020 505014 Positive_regulation IL8 TNF 25053922 1627948 Positive_regulation IL8 TNF 25071589 965547 Positive_regulation IL8 TNF 25110464 1627995 Positive_regulation IL8 TNF 25123797 368564 Positive_regulation IL8 TNF 25143751 645509 Positive_regulation IL8 TNF 25165691 198099 Positive_regulation IL8 TNF 25239871 32264 Positive_regulation IL8 TNF 25250322 199953 Positive_regulation IL8 TNF 25333927 3018019 Positive_regulation IL8 TNF 25349560 1147406 Positive_regulation IL8 TNF 25479074 1135577 Positive_regulation IL8 TNF 2549166 1577312 Positive_regulation IL8 TNF 25501329 1135635 Positive_regulation IL8 TNF 25501580 3033656 Positive_regulation IL8 TNF 25558168 142129 Positive_regulation IL8 TNF 2642531 1577580 Positive_regulation IL8 TNF 2647892 1577586 Positive_regulation IL8 TNF 2659724 1577669 Positive_regulation IL8 TNF 2769183 1577894 Positive_regulation IL8 TNF 2785398 442936 Positive_regulation IL8 TNF 2803928 443157 Positive_regulation IL8 TNF 2833558 1578548 Positive_regulation IL8 TNF 2926331 1578679 Positive_regulation IL8 TNF 3049617 1425498 Positive_regulation IL8 TNF 3049617 1425499 Positive_regulation IL8 TNF 3049617 1425606 Positive_regulation IL8 TNF 3049617 1425607 Positive_regulation IL8 TNF 3110354 1580067 Positive_regulation IL8 TNF 3137305 1580380 Positive_regulation IL8 TNF 3143799 1580435 Positive_regulation IL8 TNF 3260265 1580609 Positive_regulation IL8 TNF 3260265 1580613 Positive_regulation IL8 TNF 3290384 1580801 Positive_regulation IL8 TNF 3309124 1580920 Positive_regulation IL8 TNF 3309124 1580974 Positive_regulation IL8 TNF 3316469 1581034 Positive_regulation IL8 TNF 3411293 1581200 Positive_regulation IL8 TNF 3435706 443515 Positive_regulation IL8 TNF 3491174 1583107 Positive_regulation IL8 TNF 3494807 1583283 Positive_regulation IL8 TNF 3494807 1583284 Positive_regulation IL8 TNF 3494807 1583345 Positive_regulation IL8 TNF 3572302 1583483 Positive_regulation IL8 TNF 3598461 1583542 Positive_regulation IL8 TNF 3598461 1583576 Positive_regulation IL8 TNF 3819645 1583718 Positive_regulation IL8 TNF 7500047 1588523 Positive_regulation IL8 TNF 7500047 1588524 Positive_regulation IL8 TNF 7500047 1588530 Positive_regulation IL8 TNF 7513008 1589104 Positive_regulation IL8 TNF 7595221 1590919 Positive_regulation IL8 TNF 7669585 444131 Positive_regulation IL8 TNF 7679713 1591415 Positive_regulation IL8 TNF 8064229 1593930 Positive_regulation IL8 TNF 8064229 1593931 Positive_regulation IL8 TNF 8354170 796832 Positive_regulation IL8 TNF 8382509 444845 Positive_regulation IL8 TNF 8426121 1595210 Positive_regulation IL8 TNF 8478614 1595560 Positive_regulation IL8 TNF 9539011 797723 Positive_regulation IL8 TNF 9547339 1602655 Positive_regulation IL8 TNF 9547339 1602658 Positive_regulation IL8 TNF 9839698 1764089 Positive_regulation IL8 TNF 9839698 1764097 Positive_regulation IL8 TNF 9883969 1764117 Positive_regulation IL8 TNF PMC2188223 1605409 Positive_regulation IL8 TNF PMC2834114 134583 Positive_regulation IL8 TNF PMC2834114 134588 Positive_regulation IL8 TNF PMC3273219 99572 Positive_regulation IL8 TNF PMC3301465 660977 Positive_regulation IL8 TNF PMC3663404 1731559 Positive_regulation IL8 TNF PMC4033969 2245917 Positive_regulation IL8 TNF PMC4212306 3206360 Positive_regulation IL8 TNF PMC4212306 3206486 Positive_regulation IL8 TNFSF10 21562052 1637160 Positive_regulation IL8 TNFSF10 23096115 557881 Positive_regulation IL9 CD14 25025695 2989362 Positive_regulation IL9 LBP 25025695 2989363 Positive_regulation IL9 MUC16 20053303 118088 Positive_regulation IL9 PECAM1 23819059 1150800 Positive_regulation IL9 TLR7 11686880 3103316 Positive_regulation IL9 TLR7 21983833 1955909 Positive_regulation IL9 TLR7 22783250 902102 Positive_regulation IL9 TNF 1311016 1528345 Positive_regulation IL9 TNF 1586593 426067 Positive_regulation IL9 TNF 1643416 702489 Positive_regulation IL9 TNF 1692079 1542201 Positive_regulation IL9 TNF 1717633 1543742 Positive_regulation IL9 TNF 18475440 1743784 Positive_regulation IL9 TNF 1911209 431587 Positive_regulation IL9 TNF 19742190 1048194 Positive_regulation IL9 TNF 19936089 981581 Positive_regulation IL9 TNF 2007858 1557315 Positive_regulation IL9 TNF 2022925 1557593 Positive_regulation IL9 TNF 2022925 1557621 Positive_regulation IL9 TNF 2039696 434775 Positive_regulation IL9 TNF 20808962 2473152 Positive_regulation IL9 TNF 21829352 3052813 Positive_regulation IL9 TNF 2183871 437522 Positive_regulation IL9 TNF 2183871 437603 Positive_regulation IL9 TNF 2183871 437604 Positive_regulation IL9 TNF 2183871 437632 Positive_regulation IL9 TNF 2258696 1568209 Positive_regulation IL9 TNF 2373990 1572284 Positive_regulation IL9 TNF 2406363 1573715 Positive_regulation IL9 TNF 2499653 1577004 Positive_regulation IL9 TNF 2642531 1577581 Positive_regulation IL9 TNF 2659724 1577670 Positive_regulation IL9 TNF 2769183 1577895 Positive_regulation IL9 TNF 2785398 442937 Positive_regulation IL9 TNF 2803928 443158 Positive_regulation IL9 TNF 2833558 1578549 Positive_regulation IL9 TNF 3049617 1425500 Positive_regulation IL9 TNF 3049617 1425501 Positive_regulation IL9 TNF 3049617 1425608 Positive_regulation IL9 TNF 3049617 1425609 Positive_regulation IL9 TNF 3110354 1580068 Positive_regulation IL9 TNF 3137305 1580381 Positive_regulation IL9 TNF 3143799 1580436 Positive_regulation IL9 TNF 3290384 1580802 Positive_regulation IL9 TNF 3309124 1580921 Positive_regulation IL9 TNF 3309124 1580975 Positive_regulation IL9 TNF 3316469 1581035 Positive_regulation IL9 TNF 3411293 1581201 Positive_regulation IL9 TNF 3435706 443516 Positive_regulation IL9 TNF 3491174 1583108 Positive_regulation IL9 TNF 3494807 1583285 Positive_regulation IL9 TNF 3494807 1583286 Positive_regulation IL9 TNF 3494807 1583346 Positive_regulation IL9 TNF 3572302 1583484 Positive_regulation IL9 TNF 3598461 1583543 Positive_regulation IL9 TNF 3598461 1583577 Positive_regulation IL9 TNF 3819645 1583719 Positive_regulation IL9 TNF 8426121 1595211 Positive_regulation IL9 TNF 8478614 1595561 Positive_regulation IL9 TNF PMC2188223 1605410 Positive_regulation ILK ANKRD1 PMC4033950 2245723 Positive_regulation ILK CCND1 20565980 465633 Positive_regulation ILK PLAU 23645983 3188968 Positive_regulation ING1 CDKN1C 23472054 2282151 Positive_regulation INHBA CCND1 24628936 539600 Positive_regulation INHBA NES 22132182 2574314 Positive_regulation INHBA TNF 22313861 3160878 Positive_regulation INHBA TNF 22313861 3160879 Positive_regulation INHBA TNF 22313861 3160880 Positive_regulation INHBA TNF 22313861 3160881 Positive_regulation INHBA TNF 22313861 3160882 Positive_regulation INHBA TNF 22313861 3160908 Positive_regulation INHBA TNF 22313861 3160948 Positive_regulation INHBA TNF 22313861 3160949 Positive_regulation INHBA TNF 22313861 3160972 Positive_regulation INHBA TNF 22313861 3161019 Positive_regulation INHBA TNF 22313861 3161021 Positive_regulation INHBA TNF 22313861 3161025 Positive_regulation INHBA TNF 22476871 1238666 Positive_regulation INHBA TNF 23956746 1073666 Positive_regulation INHBA TNF 24899891 1074253 Positive_regulation INHBB CNP 17374144 299876 Positive_regulation INPP4B EPHB2 22895072 478778 Positive_regulation INPP4B EPHB2 22895072 478783 Positive_regulation INPP4B EPHB2 22895072 478798 Positive_regulation INPP4B EPHB2 22895072 478802 Positive_regulation INPP4B EPHB2 22895072 478814 Positive_regulation INPP4B GRAP2 22895072 478815 Positive_regulation INPP4B INPP4A 22895072 478810 Positive_regulation INS ACSS1 22275878 2328875 Positive_regulation INS ARSG 22194889 2583270 Positive_regulation INS EDN2 23573411 1080989 Positive_regulation INS ENPP1 21573217 2522973 Positive_regulation INS ENPP1 21573217 2522975 Positive_regulation INS EPHB2 19502418 708723 Positive_regulation INS EPHB2 21286247 1028345 Positive_regulation INS EPHB2 22649417 875450 Positive_regulation INS EPHB2 22662132 2647035 Positive_regulation INS EPHB2 22875989 1806409 Positive_regulation INS EPHB2 23112573 1915251 Positive_regulation INS EPHB2 23468892 2760179 Positive_regulation INS EPHB2 23969997 839421 Positive_regulation INS EPHB2 24130927 204553 Positive_regulation INS EPHB2 24282611 2886471 Positive_regulation INS EPHB2 24324549 2890732 Positive_regulation INS EPHB2 24324549 2890734 Positive_regulation INS EPHB2 24533136 2922370 Positive_regulation INS EPHB2 24575365 20596 Positive_regulation INS EPHB2 25114508 743196 Positive_regulation INS FAS 22966071 724680 Positive_regulation INS FOXO1 12967350 3095106 Positive_regulation INS FOXO1 18506144 430616 Positive_regulation INS FOXO1 20028942 712390 Positive_regulation INS FOXO1 20650821 1031177 Positive_regulation INS FOXO1 20664791 3048190 Positive_regulation INS FOXO1 21209957 2492629 Positive_regulation INS FOXO1 21335550 1190775 Positive_regulation INS FOXO1 21335550 1190776 Positive_regulation INS FOXO1 21335550 1190785 Positive_regulation INS FOXO1 21483870 2512499 Positive_regulation INS FOXO1 22344295 1962147 Positive_regulation INS FOXO1 22586579 722751 Positive_regulation INS FOXO1 22815850 2666427 Positive_regulation INS FOXO1 22923651 724218 Positive_regulation INS FOXO1 23462798 733750 Positive_regulation INS FOXO1 23614736 830052 Positive_regulation INS FOXO1 23734095 938126 Positive_regulation INS FOXO1 23737653 1753203 Positive_regulation INS FOXO1 23878722 749572 Positive_regulation INS FOXO1 23885240 961970 Positive_regulation INS FOXO1 24244124 2298993 Positive_regulation INS FOXO1 24244197 2352937 Positive_regulation INS FOXO1 24490110 3151519 Positive_regulation INS FOXO1 24609035 741031 Positive_regulation INS FOXO1 24843827 589769 Positive_regulation INS FOXO1 24968248 3068308 Positive_regulation INS FOXO1 25136826 2998925 Positive_regulation INS FOXO1 25257998 1767509 Positive_regulation INS G0S2 23951308 2834134 Positive_regulation INS GLP1R 20215429 713032 Positive_regulation INS GLP1R 20215429 713033 Positive_regulation INS GLP1R 20582183 1046617 Positive_regulation INS GLP1R 20823098 716468 Positive_regulation INS GLP1R 21731863 1044100 Positive_regulation INS GLP1R 21876656 648755 Positive_regulation INS GLP1R 22101168 13930 Positive_regulation INS GLP1R 22101168 13936 Positive_regulation INS GLP1R 22666230 833110 Positive_regulation INS GLP1R 22776039 731710 Positive_regulation INS GLP1R 22776039 731744 Positive_regulation INS GLP1R 22776039 731750 Positive_regulation INS GLP1R 22776039 731756 Positive_regulation INS GLP1R 22776039 731757 Positive_regulation INS GLP1R 22776039 731758 Positive_regulation INS GLP1R 23341736 2234802 Positive_regulation INS GLP1R 23349500 725946 Positive_regulation INS GLP1R 23578994 727064 Positive_regulation INS GLP1R 23882044 730201 Positive_regulation INS GLP1R 24244813 204867 Positive_regulation INS GLP1R 24695667 2948309 Positive_regulation INS GLP1R 24695667 2948310 Positive_regulation INS GLP1R 24695667 2948312 Positive_regulation INS GLP1R 24843641 1494270 Positive_regulation INS GLP1R 25413047 733863 Positive_regulation INS HBEGF 25060396 492928 Positive_regulation INS ID1 21940780 720681 Positive_regulation INS ID1 21940780 720682 Positive_regulation INS ID1 21940780 720688 Positive_regulation INS IGFBP1 21984534 776817 Positive_regulation INS IGFBP1 24204984 2875084 Positive_regulation INS IGFBP1 24829560 880576 Positive_regulation INS IL1B 25377254 1884332 Positive_regulation INS IRS4 24567904 1887818 Positive_regulation INS KRT38 23166623 2718173 Positive_regulation INS MAP2K6 24282611 2886477 Positive_regulation INS NES 24600221 1138209 Positive_regulation INS NMNAT2 21998399 720867 Positive_regulation INS PCSK9 19687008 1166615 Positive_regulation INS PDE8B 21152070 2486068 Positive_regulation INS PGC 21629705 1155264 Positive_regulation INS STAT4 23939393 728373 Positive_regulation INS TGM2 1356992 1297651 Positive_regulation INS TGM2 19859528 2269635 Positive_regulation INS TLR7 24758278 1726873 Positive_regulation INS TNF 17971205 507799 Positive_regulation INS TNF 19188427 707840 Positive_regulation INS TNF 19188427 707939 Positive_regulation INS TNF 19558671 1722868 Positive_regulation INS TNF 22691241 126152 Positive_regulation INS TNF 22942720 1097107 Positive_regulation INS TNF 22942720 1097108 Positive_regulation INS TNF 22942720 1097109 Positive_regulation INS TNF 23056223 2700724 Positive_regulation INS TNF 23193206 729940 Positive_regulation INS TNF 23383064 2747716 Positive_regulation INS TNF 23437347 2756510 Positive_regulation INS TNF 24466329 2914362 Positive_regulation INS TNF 24575371 20612 Positive_regulation INS TNF 24692847 1757849 Positive_regulation INS TNF 24741627 1621358 Positive_regulation INS TNF 24966659 1917101 Positive_regulation INS TNF 25258478 1762462 Positive_regulation INS TNF 25309049 1763060 Positive_regulation INS TNF 25352752 1917447 Positive_regulation INS TNF 25421245 1135272 Positive_regulation INS TUB 22966070 724647 Positive_regulation INS TUB 22966070 724648 Positive_regulation INS TUB 22966070 724649 Positive_regulation INS TUB 25031889 788255 Positive_regulation INSR EPHB2 21119656 436259 Positive_regulation INSR FOXO1 23844554 473464 Positive_regulation INSR FOXO1 23878722 749557 Positive_regulation INSR FOXO1 23878722 749576 Positive_regulation INSR FOXO1 24489697 2916061 Positive_regulation INSR TNF 22654787 875805 Positive_regulation INSR TNF 25352752 1917448 Positive_regulation INSRR TNF 1385447 1298495 Positive_regulation INTS2 CTGF 22045431 737000 Positive_regulation IPO11 TNF 21399639 1955144 Positive_regulation IPO13 TNF 21399639 1955141 Positive_regulation IPO4 TNF 21399639 1955143 Positive_regulation IPO5 TNF 21399639 1955145 Positive_regulation IPO7 TNF 21399639 1955146 Positive_regulation IPO8 TNF 21399639 1955147 Positive_regulation IPO9 TNF 21399639 1955142 Positive_regulation IQGAP1 SPHK1 21304987 2502024 Positive_regulation IQGAP3 EPHB2 24849319 2972487 Positive_regulation IRAK1 TLR7 17485511 1545579 Positive_regulation IRAK1 TLR7 17485511 1545580 Positive_regulation IRAK1 TLR7 17485511 1545758 Positive_regulation IRAK1 TLR7 21743479 1955544 Positive_regulation IRAK1 TLR7 21743479 1955545 Positive_regulation IRAK1 TLR7 21743479 1955609 Positive_regulation IRAK1 TLR7 23508732 906466 Positive_regulation IRAK1 TLR7 24744784 1074093 Positive_regulation IRAK1 TNF 22623923 900962 Positive_regulation IRAK1 TNF 23104095 1958275 Positive_regulation IRAK1 TNF 23680172 1626981 Positive_regulation IRAK1BP1 TLR7 18268037 1549317 Positive_regulation IRAK1BP1 TLR7 18268037 1549330 Positive_regulation IRAK1BP1 TLR7 PMC2271012 1605522 Positive_regulation IRAK2 TLR7 18606009 1655554 Positive_regulation IRAK2 TNF 22623923 900963 Positive_regulation IRAK3 EPHB2 21390243 1049767 Positive_regulation IRAK3 EPHB2 22928050 2681886 Positive_regulation IRAK3 TLR7 22928050 2681736 Positive_regulation IRAK3 TLR7 22928050 2681795 Positive_regulation IRAK3 TLR7 22928050 2681841 Positive_regulation IRAK3 TLR7 22928050 2681903 Positive_regulation IRAK3 TLR7 22928050 2681943 Positive_regulation IRAK3 TLR7 22928050 2681979 Positive_regulation IRAK3 TLR7 22928050 2682000 Positive_regulation IRAK3 TLR7 22928050 2682030 Positive_regulation IRAK3 TLR7 23776703 2805651 Positive_regulation IRAK3 TLR7 23776703 2805662 Positive_regulation IRAK3 TNF 20585389 2453857 Positive_regulation IRAK3 TNF 21390243 1049801 Positive_regulation IRAK3 TNF 22623923 900960 Positive_regulation IRAK4 TLR7 17485511 1545748 Positive_regulation IRAK4 TLR7 17893200 1547159 Positive_regulation IRAK4 TLR7 22876248 902994 Positive_regulation IRAK4 TLR7 23565116 906725 Positive_regulation IRAK4 TNF 22623923 900961 Positive_regulation IRF1 TLR7 15851485 1535805 Positive_regulation IRF1 TLR7 15851485 1535961 Positive_regulation IRF1 TLR7 20694832 1027735 Positive_regulation IRF1 TLR7 20929569 403205 Positive_regulation IRF1 TLR7 21633096 1992297 Positive_regulation IRF1 TLR7 24464131 1959721 Positive_regulation IRF1 TLR7 25170774 3003966 Positive_regulation IRF1 TNF 19687227 1555824 Positive_regulation IRF1 TNF 19934004 711871 Positive_regulation IRF1 TNF 20615213 119677 Positive_regulation IRF1 TNF 21992116 1697925 Positive_regulation IRF1 TNF 23626590 906835 Positive_regulation IRF1 TNF 23807161 441014 Positive_regulation IRF1 TNF 23807161 441015 Positive_regulation IRF1 TNF 23807161 441017 Positive_regulation IRF1 TNF 24464131 1959720 Positive_regulation IRF1 TNF 24464131 1959784 Positive_regulation IRF1 TNF 24516119 1574974 Positive_regulation IRF1 TNF PMC3990328 1623671 Positive_regulation IRF2 MYH16 9490737 1466666 Positive_regulation IRF2 MYH3 9490737 1466673 Positive_regulation IRF2 TLR7 20694832 1027745 Positive_regulation IRF2 TLR7 20929569 403215 Positive_regulation IRF2 TLR7 21633096 1992307 Positive_regulation IRF3 TLR7 15767367 1534863 Positive_regulation IRF3 TLR7 18268035 1549093 Positive_regulation IRF3 TLR7 20694832 1027755 Positive_regulation IRF3 TLR7 20929569 403225 Positive_regulation IRF3 TLR7 21488180 3232628 Positive_regulation IRF3 TLR7 21625524 2524689 Positive_regulation IRF3 TLR7 21633096 1992317 Positive_regulation IRF3 TLR7 21964925 600356 Positive_regulation IRF3 TLR7 22208359 1660538 Positive_regulation IRF3 TLR7 22414065 398551 Positive_regulation IRF3 TLR7 22997518 24983 Positive_regulation IRF3 TLR7 23305364 693929 Positive_regulation IRF3 TLR7 23532979 1732290 Positive_regulation IRF3 TLR7 23532979 1732291 Positive_regulation IRF3 TLR7 24270516 1959395 Positive_regulation IRF3 TLR7 24708794 1667938 Positive_regulation IRF3 TLR7 25101271 195745 Positive_regulation IRF3 TLR7 25140116 1761062 Positive_regulation IRF3 TNF 19753301 2426485 Positive_regulation IRF3 TNF 23626590 906836 Positive_regulation IRF3 TNFSF10 24369016 185969 Positive_regulation IRF4 EPHB2 24765092 912344 Positive_regulation IRF4 FOXO1 23835343 727936 Positive_regulation IRF4 TLR7 20694832 1027765 Positive_regulation IRF4 TLR7 20929569 403235 Positive_regulation IRF4 TLR7 21633096 1992327 Positive_regulation IRF5 TLR7 19430534 2416260 Positive_regulation IRF5 TLR7 19430534 2416261 Positive_regulation IRF5 TLR7 20672047 1747589 Positive_regulation IRF5 TLR7 20694832 1027775 Positive_regulation IRF5 TLR7 20929569 403245 Positive_regulation IRF5 TLR7 21253574 3050372 Positive_regulation IRF5 TLR7 21253574 3050373 Positive_regulation IRF5 TLR7 21253574 3050374 Positive_regulation IRF5 TLR7 21253574 3050429 Positive_regulation IRF5 TLR7 21253574 3050430 Positive_regulation IRF5 TLR7 21253574 3050431 Positive_regulation IRF5 TLR7 21253574 3050460 Positive_regulation IRF5 TLR7 21396113 121752 Positive_regulation IRF5 TLR7 21633096 1992337 Positive_regulation IRF5 TLR7 22649649 4038 Positive_regulation IRF5 TLR7 23514422 1683695 Positive_regulation IRF5 TLR7 24453413 1756686 Positive_regulation IRF5 TLR7 25084355 2994325 Positive_regulation IRF5 TLR7 25084355 2994371 Positive_regulation IRF5 TLR7 25084355 2994419 Positive_regulation IRF5 TNF 19430534 2416333 Positive_regulation IRF6 TLR7 20694832 1027785 Positive_regulation IRF6 TLR7 20929569 403255 Positive_regulation IRF6 TLR7 21633096 1992347 Positive_regulation IRF6 TP63 24940735 2980719 Positive_regulation IRF6 TP63 24940735 2980723 Positive_regulation IRF7 OASL 24393529 222598 Positive_regulation IRF7 OASL 24393529 222600 Positive_regulation IRF7 OASL 24393529 222602 Positive_regulation IRF7 TLR7 15851485 1535988 Positive_regulation IRF7 TLR7 17935622 352046 Positive_regulation IRF7 TLR7 19430534 2416263 Positive_regulation IRF7 TLR7 19801985 1953255 Positive_regulation IRF7 TLR7 20548099 1376777 Positive_regulation IRF7 TLR7 20668674 2457306 Positive_regulation IRF7 TLR7 20694832 1027795 Positive_regulation IRF7 TLR7 20929569 403265 Positive_regulation IRF7 TLR7 21092113 1043685 Positive_regulation IRF7 TLR7 21197425 979827 Positive_regulation IRF7 TLR7 21488180 3232630 Positive_regulation IRF7 TLR7 21633096 1992357 Positive_regulation IRF7 TLR7 21743479 1955570 Positive_regulation IRF7 TLR7 21743479 1955602 Positive_regulation IRF7 TLR7 21826793 776592 Positive_regulation IRF7 TLR7 21893536 2250063 Positive_regulation IRF7 TLR7 21994560 3218477 Positive_regulation IRF7 TLR7 21994609 3218892 Positive_regulation IRF7 TLR7 21994785 3220455 Positive_regulation IRF7 TLR7 22570745 1024148 Positive_regulation IRF7 TLR7 22649649 4039 Positive_regulation IRF7 TLR7 22661952 957513 Positive_regulation IRF7 TLR7 22952664 2683551 Positive_regulation IRF7 TLR7 23305364 694090 Positive_regulation IRF7 TLR7 23435233 3222263 Positive_regulation IRF7 TLR7 23758787 1649740 Positive_regulation IRF7 TLR7 24489947 2917049 Positive_regulation IRF7 TLR7 24708794 1667940 Positive_regulation IRF7 TLR7 24892454 653889 Positive_regulation IRF7 TLR7 25101271 195756 Positive_regulation IRF7 TLR7 25140116 1761066 Positive_regulation IRF7 TLR7 25294957 1762975 Positive_regulation IRF7 TNF 18617992 3041643 Positive_regulation IRF7 TNF 18617992 3041651 Positive_regulation IRF7 TNF 19934004 711861 Positive_regulation IRF7 TNF 19934004 711872 Positive_regulation IRF7 TNFSF10 24369016 185970 Positive_regulation IRF8 EPHB2 24765092 912339 Positive_regulation IRF8 TLR7 20694832 1027725 Positive_regulation IRF8 TLR7 20929569 403155 Positive_regulation IRF8 TLR7 21633096 1992287 Positive_regulation IRF8 TLR7 22610140 1957372 Positive_regulation IRF8 TLR7 24155889 2871028 Positive_regulation IRF9 STAT4 25309545 914600 Positive_regulation IRF9 TLR7 20694832 1027805 Positive_regulation IRF9 TLR7 20929569 403275 Positive_regulation IRF9 TLR7 21633096 1992367 Positive_regulation IRG1 MSX1 22254040 2115987 Positive_regulation IRS1 EPHB2 19953085 1903255 Positive_regulation IRS1 TNF 20023693 8556 Positive_regulation IRS1 TNF 21386087 718320 Positive_regulation IRS1 TNF 21386087 718321 Positive_regulation IRS1 TNF 22234148 1641017 Positive_regulation IRS1 TNF 22691241 126143 Positive_regulation IRS1 TNF 22823902 732153 Positive_regulation IRS1 TNF 22919275 1224830 Positive_regulation IRS1 TNF 22942720 1097121 Positive_regulation IRS1 TNF 23781214 878821 Positive_regulation IRS1 TNF 24101950 2227290 Positive_regulation IRS1 TNF 24386594 86027 Positive_regulation IRS1 TNF 24481061 1123554 Positive_regulation IRS1 TNF 25352752 1917489 Positive_regulation IRS1 TNF 25352752 1917494 Positive_regulation IRS1 WNT7A 22179044 1928143 Positive_regulation IRS2 EPHB2 22477519 1239082 Positive_regulation IRS2 FOXO1 21933986 720636 Positive_regulation IRS2 FOXO1 22384192 2607228 Positive_regulation IRS2 FOXO1 23202496 3221821 Positive_regulation IRS2 FOXO1 23614736 830053 Positive_regulation IRS2 MAP2K6 22477519 1239088 Positive_regulation IRS2 TNF 24101950 2227304 Positive_regulation IRS4 ASB3 23901248 1916150 Positive_regulation IRS4 ASB4 21955513 387325 Positive_regulation IRS4 ASB4 21955513 387326 Positive_regulation IRS4 ASB4 21955513 387332 Positive_regulation IRS4 ASB9 23901248 1916151 Positive_regulation IRS4 IRS1 17156427 279434 Positive_regulation IRS4 TRB 24886479 3124697 Positive_regulation ISG15 TLR7 24708794 1667946 Positive_regulation ISG20 TLR7 24708794 1667956 Positive_regulation ISL1 CCND1 21829621 2542086 Positive_regulation ISL1 MAP2K6 19077309 1994071 Positive_regulation ISM2 CASP8 21544092 551889 Positive_regulation ITCH EPHB2 24708812 1843039 Positive_regulation ITCH EPHB2 24708812 1843040 Positive_regulation ITCH EPHB2 24708812 1843041 Positive_regulation ITCH EPHB2 24708812 1843048 Positive_regulation ITCH EPHB2 24708812 1843051 Positive_regulation ITCH HRH1 18667087 1897065 Positive_regulation ITCH TLR7 23216829 1899479 Positive_regulation ITCH TLR7 24795573 933992 Positive_regulation ITCH TNF 22507528 1661613 Positive_regulation ITGA2B HES2 21906324 89052 Positive_regulation ITGA4 ITGAL 7532681 1590060 Positive_regulation ITGA4 ITGB2 7532681 1590058 Positive_regulation ITGA5 FOXO1 24864265 191779 Positive_regulation ITGA9 MYLIP 24803669 2100785 Positive_regulation ITGAD ITGB2 PMC2323483 1733590 Positive_regulation ITGAE TLR7 25024136 1577077 Positive_regulation ITGAL ACD 20733035 1559702 Positive_regulation ITGAL C5 2565948 1577438 Positive_regulation ITGAL CA2 7510713 1435250 Positive_regulation ITGAL CAPN1 20479866 2449906 Positive_regulation ITGAL CAPN1 22046434 2567867 Positive_regulation ITGAL CAPN10 20479866 2449907 Positive_regulation ITGAL CAPN10 22046434 2567868 Positive_regulation ITGAL CAPN11 20479866 2449908 Positive_regulation ITGAL CAPN11 22046434 2567869 Positive_regulation ITGAL CAPN12 20479866 2449905 Positive_regulation ITGAL CAPN12 22046434 2567866 Positive_regulation ITGAL CAPN13 20479866 2449916 Positive_regulation ITGAL CAPN13 22046434 2567877 Positive_regulation ITGAL CAPN14 20479866 2449917 Positive_regulation ITGAL CAPN14 22046434 2567878 Positive_regulation ITGAL CAPN15 20479866 2449904 Positive_regulation ITGAL CAPN15 22046434 2567865 Positive_regulation ITGAL CAPN2 20479866 2449909 Positive_regulation ITGAL CAPN2 22046434 2567870 Positive_regulation ITGAL CAPN3 20479866 2449910 Positive_regulation ITGAL CAPN3 22046434 2567871 Positive_regulation ITGAL CAPN5 20479866 2449911 Positive_regulation ITGAL CAPN5 22046434 2567872 Positive_regulation ITGAL CAPN6 20479866 2449912 Positive_regulation ITGAL CAPN6 22046434 2567873 Positive_regulation ITGAL CAPN7 20479866 2449913 Positive_regulation ITGAL CAPN7 22046434 2567874 Positive_regulation ITGAL CAPN8 20479866 2449914 Positive_regulation ITGAL CAPN8 22046434 2567875 Positive_regulation ITGAL CAPN9 20479866 2449915 Positive_regulation ITGAL CAPN9 22046434 2567876 Positive_regulation ITGAL CCL18 23999500 1573557 Positive_regulation ITGAL CCL21 10620605 1513830 Positive_regulation ITGAL CCL21 24945611 2981346 Positive_regulation ITGAL CCL21 24945611 2981353 Positive_regulation ITGAL CCL21 24945611 2981361 Positive_regulation ITGAL CD14 7535337 1590140 Positive_regulation ITGAL CD2 1560035 1317363 Positive_regulation ITGAL CD226 12913096 1528202 Positive_regulation ITGAL CD226 14676297 1529991 Positive_regulation ITGAL CD226 14676297 1529992 Positive_regulation ITGAL CD226 14676297 1530007 Positive_regulation ITGAL CD226 14676297 1530008 Positive_regulation ITGAL CD244 24445602 1042515 Positive_regulation ITGAL CD244 25475707 3147861 Positive_regulation ITGAL CD28 1569401 1534408 Positive_regulation ITGAL CD40 25324844 914640 Positive_regulation ITGAL CD47 24006483 1817983 Positive_regulation ITGAL CD47 24006483 1817984 Positive_regulation ITGAL CD47 24006483 1817985 Positive_regulation ITGAL CD47 24006483 1818010 Positive_regulation ITGAL CD53 24832104 2970510 Positive_regulation ITGAL CD53 24832104 2970514 Positive_regulation ITGAL CD53 24832104 2970522 Positive_regulation ITGAL CD53 24832104 2970526 Positive_regulation ITGAL CD81 12597781 350426 Positive_regulation ITGAL CELP 8920885 1599489 Positive_regulation ITGAL COL1A2 25414732 641071 Positive_regulation ITGAL CXCL12 18195072 1548557 Positive_regulation ITGAL CXCL12 24368807 1413130 Positive_regulation ITGAL CXCL12 24368807 1413268 Positive_regulation ITGAL CXCL12 PMC3871424 1478217 Positive_regulation ITGAL F11R 15136589 1532310 Positive_regulation ITGAL FYB 22291096 1567041 Positive_regulation ITGAL GPR1 10620605 1513987 Positive_regulation ITGAL GPR101 10620605 1513943 Positive_regulation ITGAL GPR107 10620605 1513948 Positive_regulation ITGAL GPR108 10620605 1513947 Positive_regulation ITGAL GPR110 10620605 1513953 Positive_regulation ITGAL GPR111 10620605 1513954 Positive_regulation ITGAL GPR112 10620605 1513955 Positive_regulation ITGAL GPR113 10620605 1513952 Positive_regulation ITGAL GPR114 10620605 1513956 Positive_regulation ITGAL GPR115 10620605 1513957 Positive_regulation ITGAL GPR116 10620605 1513958 Positive_regulation ITGAL GPR119 10620605 1513959 Positive_regulation ITGAL GPR12 10620605 1513988 Positive_regulation ITGAL GPR123 10620605 1513940 Positive_regulation ITGAL GPR124 10620605 1513949 Positive_regulation ITGAL GPR125 10620605 1513941 Positive_regulation ITGAL GPR126 10620605 1513942 Positive_regulation ITGAL GPR128 10620605 1513960 Positive_regulation ITGAL GPR132 10620605 1513946 Positive_regulation ITGAL GPR133 10620605 1513961 Positive_regulation ITGAL GPR135 10620605 1513962 Positive_regulation ITGAL GPR137 10620605 1513980 Positive_regulation ITGAL GPR139 10620605 1513963 Positive_regulation ITGAL GPR141 10620605 1513964 Positive_regulation ITGAL GPR142 10620605 1513965 Positive_regulation ITGAL GPR143 10620605 1513966 Positive_regulation ITGAL GPR144 10620605 1513951 Positive_regulation ITGAL GPR146 10620605 1513968 Positive_regulation ITGAL GPR148 10620605 1513972 Positive_regulation ITGAL GPR149 10620605 1513974 Positive_regulation ITGAL GPR15 10620605 1513989 Positive_regulation ITGAL GPR150 10620605 1513975 Positive_regulation ITGAL GPR151 10620605 1513973 Positive_regulation ITGAL GPR152 10620605 1513971 Positive_regulation ITGAL GPR153 10620605 1513970 Positive_regulation ITGAL GPR155 10620605 1513969 Positive_regulation ITGAL GPR156 10620605 1513967 Positive_regulation ITGAL GPR157 10620605 1513976 Positive_regulation ITGAL GPR158 10620605 1513977 Positive_regulation ITGAL GPR160 10620605 1513978 Positive_regulation ITGAL GPR161 10620605 1513979 Positive_regulation ITGAL GPR162 10620605 1513944 Positive_regulation ITGAL GPR17 10620605 1513990 Positive_regulation ITGAL GPR171 10620605 1513982 Positive_regulation ITGAL GPR173 10620605 1513950 Positive_regulation ITGAL GPR174 10620605 1513983 Positive_regulation ITGAL GPR176 10620605 1513986 Positive_regulation ITGAL GPR179 10620605 1513985 Positive_regulation ITGAL GPR18 10620605 1513991 Positive_regulation ITGAL GPR180 10620605 1513981 Positive_regulation ITGAL GPR182 10620605 1513938 Positive_regulation ITGAL GPR183 10620605 1513984 Positive_regulation ITGAL GPR19 10620605 1513992 Positive_regulation ITGAL GPR20 10620605 1513993 Positive_regulation ITGAL GPR21 10620605 1513994 Positive_regulation ITGAL GPR22 10620605 1513995 Positive_regulation ITGAL GPR25 10620605 1513996 Positive_regulation ITGAL GPR26 10620605 1513997 Positive_regulation ITGAL GPR27 10620605 1513998 Positive_regulation ITGAL GPR3 10620605 1513999 Positive_regulation ITGAL GPR31 10620605 1514000 Positive_regulation ITGAL GPR32 10620605 1514001 Positive_regulation ITGAL GPR33 10620605 1514002 Positive_regulation ITGAL GPR34 10620605 1514003 Positive_regulation ITGAL GPR35 10620605 1514004 Positive_regulation ITGAL GPR36 10620605 1514005 Positive_regulation ITGAL GPR37 10620605 1514006 Positive_regulation ITGAL GPR39 10620605 1514007 Positive_regulation ITGAL GPR4 10620605 1514008 Positive_regulation ITGAL GPR42 10620605 1514009 Positive_regulation ITGAL GPR45 10620605 1514010 Positive_regulation ITGAL GPR50 10620605 1514011 Positive_regulation ITGAL GPR52 10620605 1514012 Positive_regulation ITGAL GPR55 10620605 1514013 Positive_regulation ITGAL GPR56 10620605 1514014 Positive_regulation ITGAL GPR6 10620605 1514015 Positive_regulation ITGAL GPR61 10620605 1513935 Positive_regulation ITGAL GPR62 10620605 1513936 Positive_regulation ITGAL GPR63 10620605 1513937 Positive_regulation ITGAL GPR64 10620605 1514016 Positive_regulation ITGAL GPR65 10620605 1514017 Positive_regulation ITGAL GPR68 10620605 1514018 Positive_regulation ITGAL GPR75 10620605 1514020 Positive_regulation ITGAL GPR78 10620605 1514021 Positive_regulation ITGAL GPR79 10620605 1514022 Positive_regulation ITGAL GPR82 10620605 1514023 Positive_regulation ITGAL GPR83 10620605 1514019 Positive_regulation ITGAL GPR84 10620605 1514024 Positive_regulation ITGAL GPR85 10620605 1514025 Positive_regulation ITGAL GPR87 10620605 1514026 Positive_regulation ITGAL GPR88 10620605 1514027 Positive_regulation ITGAL GPR97 10620605 1513939 Positive_regulation ITGAL GPR98 10620605 1513945 Positive_regulation ITGAL ICAM1 12885870 1528141 Positive_regulation ITGAL ICAM1 18195072 1548554 Positive_regulation ITGAL ICAM1 22952790 2684070 Positive_regulation ITGAL ICAM1 24945611 2981359 Positive_regulation ITGAL ICAM1 7520448 1436244 Positive_regulation ITGAL ICAM2 7520448 1436245 Positive_regulation ITGAL ICAM3 7520448 1436246 Positive_regulation ITGAL ICAM4 7520448 1436247 Positive_regulation ITGAL ICAM5 7520448 1436248 Positive_regulation ITGAL IL1A 1874787 1355271 Positive_regulation ITGAL IL2 14676297 1530014 Positive_regulation ITGAL IL4 1402683 1528919 Positive_regulation ITGAL ITGA4 7532681 1590061 Positive_regulation ITGAL ITGAM 21909384 2551706 Positive_regulation ITGAL ITGB1 7532681 1590062 Positive_regulation ITGAL ITGB2 18079697 763276 Positive_regulation ITGAL ITGB2 22952790 2684071 Positive_regulation ITGAL ITIH4 20890395 3218193 Positive_regulation ITGAL ITIH4 21284901 1697051 Positive_regulation ITGAL ITIH4 21850260 2542737 Positive_regulation ITGAL ITIH4 21850260 2542738 Positive_regulation ITGAL JAK1 24368807 1413132 Positive_regulation ITGAL JAK2 24368807 1413133 Positive_regulation ITGAL JAK3 24368807 1413134 Positive_regulation ITGAL KLRAP1 24832104 2970515 Positive_regulation ITGAL LCP2 22291096 1567034 Positive_regulation ITGAL LCP2 22291096 1567042 Positive_regulation ITGAL LRPAP1 10725328 1256660 Positive_regulation ITGAL MCOLN1 1346139 1297621 Positive_regulation ITGAL MRE11A 20733035 1559705 Positive_regulation ITGAL MUC7 1370839 1297786 Positive_regulation ITGAL MYH9 18195072 1548539 Positive_regulation ITGAL NAPA 11259095 418399 Positive_regulation ITGAL NOS2 14657223 1529947 Positive_regulation ITGAL NRG1 18159252 2381632 Positive_regulation ITGAL PARP1 20733035 1559703 Positive_regulation ITGAL PDLIM7 24068937 3064206 Positive_regulation ITGAL POT1 20733035 1559700 Positive_regulation ITGAL PTPRC 8018541 444521 Positive_regulation ITGAL RAC1 21206905 2491152 Positive_regulation ITGAL RAC2 21206905 2491153 Positive_regulation ITGAL RAC2 25101192 3151839 Positive_regulation ITGAL RAD50 20733035 1559706 Positive_regulation ITGAL RFX1 21192791 121201 Positive_regulation ITGAL SELE 1710227 1334817 Positive_regulation ITGAL SELPLG 23994464 1051385 Positive_regulation ITGAL SELPLG 24312591 2889918 Positive_regulation ITGAL STK4 22412158 1567779 Positive_regulation ITGAL SYK 18045459 352096 Positive_regulation ITGAL TERF1 20733035 1559696 Positive_regulation ITGAL TERF2 20733035 1559697 Positive_regulation ITGAL TERF2IP 20733035 1559701 Positive_regulation ITGAL TINF2 20733035 1559698 Positive_regulation ITGAL TNF 11178120 98258 Positive_regulation ITGAL TNF 11178120 98259 Positive_regulation ITGAL TNF 21970746 354723 Positive_regulation ITGAL TNF 2565948 1577437 Positive_regulation ITGAL VAV1 12885870 1528134 Positive_regulation ITGAL VAV1 12885870 1528140 Positive_regulation ITGAL VAV1 24368807 1413131 Positive_regulation ITGAL VAV1 24368807 1413269 Positive_regulation ITGAL VEGFA 24955234 523147 Positive_regulation ITGAL XRCC5 20733035 1559699 Positive_regulation ITGAL XRCC6 20733035 1559704 Positive_regulation ITGAM CD14 21731671 2532002 Positive_regulation ITGAM ITGAL 21909384 2551707 Positive_regulation ITGAM ITGB2 23959798 1880546 Positive_regulation ITGAM MAP2K6 23825585 2809725 Positive_regulation ITGAM PECAM1 22850671 771966 Positive_regulation ITGAM S100B 20827421 513006 Positive_regulation ITGAM SELL 11283159 1519231 Positive_regulation ITGAM SELL 11817675 1738024 Positive_regulation ITGAM SELL 20082712 1656070 Positive_regulation ITGAM TLR7 19343210 3043628 Positive_regulation ITGAM TLR7 23573259 2778022 Positive_regulation ITGAM TLR7 24386204 2903233 Positive_regulation ITGAM TNF 12930553 658491 Positive_regulation ITGAM TNF 16879738 106491 Positive_regulation ITGAM TNF 18475516 1744136 Positive_regulation ITGAM TNF 18475518 1744165 Positive_regulation ITGAM TNF 2165128 1564033 Positive_regulation ITGAM TNF 21876832 1082211 Positive_regulation ITGAM TNF 23924945 1109772 Positive_regulation ITGAV FAS 20953353 1748405 Positive_regulation ITGAV FOXO1 24864265 191780 Positive_regulation ITGB1 ITGAL 7532681 1590063 Positive_regulation ITGB1 ITGB2 7532681 1590059 Positive_regulation ITGB1 TLR7 25351958 153507 Positive_regulation ITGB2 ACD 17692468 157354 Positive_regulation ITGB2 ACD 20733035 1559632 Positive_regulation ITGB2 ACD 24376655 2901743 Positive_regulation ITGB2 C5 18475516 1744139 Positive_regulation ITGB2 C5 18475516 1744161 Positive_regulation ITGB2 C5 18475518 1744168 Positive_regulation ITGB2 C5 18475518 1744190 Positive_regulation ITGB2 C5 2565948 1577440 Positive_regulation ITGB2 C5 9883968 1764116 Positive_regulation ITGB2 CA2 16216891 1538067 Positive_regulation ITGB2 CA2 7510713 1435240 Positive_regulation ITGB2 CA2 9298996 1463455 Positive_regulation ITGB2 CA2 9456328 1466417 Positive_regulation ITGB2 CALCR 23959798 1880516 Positive_regulation ITGB2 CCL21 24368807 1413241 Positive_regulation ITGB2 CCL21 24945611 2981356 Positive_regulation ITGB2 CCR7 10620605 1513831 Positive_regulation ITGB2 CD1B 7744962 1440116 Positive_regulation ITGB2 CD2 21469116 808256 Positive_regulation ITGB2 CD226 14676297 1529993 Positive_regulation ITGB2 CD226 14676297 1529994 Positive_regulation ITGB2 CD226 14676297 1530009 Positive_regulation ITGB2 CD226 21469116 808257 Positive_regulation ITGB2 CD244 22693444 3057068 Positive_regulation ITGB2 CD28 22888329 903069 Positive_regulation ITGB2 CD28 24376655 2901712 Positive_regulation ITGB2 CD40 22166355 1234870 Positive_regulation ITGB2 CD40 23785403 2805704 Positive_regulation ITGB2 CD40 23785403 2805707 Positive_regulation ITGB2 CD40 25324844 914641 Positive_regulation ITGB2 CD40LG 22701645 2651602 Positive_regulation ITGB2 CD40LG 23785403 2805697 Positive_regulation ITGB2 CD40LG 23785403 2805698 Positive_regulation ITGB2 CD40LG 23785403 2805708 Positive_regulation ITGB2 CD40LG 23785403 2805728 Positive_regulation ITGB2 CD44 23750158 907369 Positive_regulation ITGB2 CD44 24376813 2902253 Positive_regulation ITGB2 CD53 24832104 2970516 Positive_regulation ITGB2 CD53 24832104 2970519 Positive_regulation ITGB2 CD69 18957484 90862 Positive_regulation ITGB2 CD99 18521343 3127575 Positive_regulation ITGB2 CDC73 1717478 1335497 Positive_regulation ITGB2 CDC73 18475624 1744914 Positive_regulation ITGB2 CDC73 18475624 1744915 Positive_regulation ITGB2 CDC73 19865173 1983950 Positive_regulation ITGB2 CDC73 25344627 1722474 Positive_regulation ITGB2 CEACAM8 24740105 2954526 Positive_regulation ITGB2 CPB1 18475516 1744163 Positive_regulation ITGB2 CPB1 18475518 1744192 Positive_regulation ITGB2 CPB2 18475516 1744164 Positive_regulation ITGB2 CPB2 18475518 1744193 Positive_regulation ITGB2 CRK 12370241 1286604 Positive_regulation ITGB2 CSE 21651795 3112233 Positive_regulation ITGB2 CTLA4 24376655 2901713 Positive_regulation ITGB2 CTR9 1717478 1335498 Positive_regulation ITGB2 CTR9 18475624 1744916 Positive_regulation ITGB2 CTR9 18475624 1744917 Positive_regulation ITGB2 CTR9 19865173 1983951 Positive_regulation ITGB2 CTR9 25344627 1722475 Positive_regulation ITGB2 CTSG 23940756 2832203 Positive_regulation ITGB2 CXCL1 21970746 354725 Positive_regulation ITGB2 CXCL1 21970746 354730 Positive_regulation ITGB2 CXCL12 17576779 1546533 Positive_regulation ITGB2 CXCL12 18195072 1548540 Positive_regulation ITGB2 CXCL12 24368807 1413135 Positive_regulation ITGB2 ELAVL1 21206905 2491148 Positive_regulation ITGB2 FERMT3 22701459 901711 Positive_regulation ITGB2 GNB1 9432978 1602386 Positive_regulation ITGB2 GNG2 9432978 1602387 Positive_regulation ITGB2 HMGB1 19292913 1695940 Positive_regulation ITGB2 HMGB1 21457506 659880 Positive_regulation ITGB2 HMGB1 24603876 2932591 Positive_regulation ITGB2 HNRNPF 21847125 437701 Positive_regulation ITGB2 HNRNPH1 21847125 437702 Positive_regulation ITGB2 ICAM1 18957484 90863 Positive_regulation ITGB2 ICAM1 22140490 2574831 Positive_regulation ITGB2 ICAM1 7510713 1435241 Positive_regulation ITGB2 ICAM1 7595194 1590729 Positive_regulation ITGB2 ICAM1 7744962 1440117 Positive_regulation ITGB2 ICAM2 1676048 1540591 Positive_regulation ITGB2 ICAM2 17233909 351811 Positive_regulation ITGB2 ICAM2 7744962 1440109 Positive_regulation ITGB2 ICAM3 17233909 351812 Positive_regulation ITGB2 IL1A 20386708 2446402 Positive_regulation ITGB2 IL2 2569026 1577448 Positive_regulation ITGB2 IL4 16001979 3105088 Positive_regulation ITGB2 IL8 16091140 1624791 Positive_regulation ITGB2 IL8 18278555 87507 Positive_regulation ITGB2 IL8 18278555 87508 Positive_regulation ITGB2 IL8 1969919 1555843 Positive_regulation ITGB2 IL8 1969919 1555844 Positive_regulation ITGB2 IL8 1969919 1555848 Positive_regulation ITGB2 IL8 1969919 1555850 Positive_regulation ITGB2 IL8 21515675 1191374 Positive_regulation ITGB2 ITGAL 11259095 418402 Positive_regulation ITGB2 ITGAL 18079697 763277 Positive_regulation ITGB2 ITGAL 22952790 2684072 Positive_regulation ITGB2 ITGAL 24376655 2901693 Positive_regulation ITGB2 ITGAL 7510713 1435252 Positive_regulation ITGB2 ITGAM 25036109 2990562 Positive_regulation ITGB2 ITIH4 21850260 2542739 Positive_regulation ITGB2 JAK2 24368807 1413137 Positive_regulation ITGB2 JAK2 24368807 1413138 Positive_regulation ITGB2 JAK3 24368807 1413139 Positive_regulation ITGB2 JAK3 24368807 1413140 Positive_regulation ITGB2 KLRB1 24832104 2970523 Positive_regulation ITGB2 LCP1 24438191 1871481 Positive_regulation ITGB2 LEO1 1717478 1335501 Positive_regulation ITGB2 LEO1 18475624 1744922 Positive_regulation ITGB2 LEO1 18475624 1744923 Positive_regulation ITGB2 LEO1 19865173 1983954 Positive_regulation ITGB2 LEO1 25344627 1722478 Positive_regulation ITGB2 LTB 17957240 2379720 Positive_regulation ITGB2 LTB 21649921 1243705 Positive_regulation ITGB2 LTB 21876832 1082213 Positive_regulation ITGB2 LTB 25344627 1722479 Positive_regulation ITGB2 MAP2K3 21206905 2491098 Positive_regulation ITGB2 MAPK1 12370241 1286606 Positive_regulation ITGB2 MAPK10 12370241 1286607 Positive_regulation ITGB2 MAPK11 12370241 1286608 Positive_regulation ITGB2 MAPK12 12370241 1286609 Positive_regulation ITGB2 MAPK13 12370241 1286610 Positive_regulation ITGB2 MAPK14 12370241 1286611 Positive_regulation ITGB2 MAPK15 12370241 1286605 Positive_regulation ITGB2 MAPK3 12370241 1286612 Positive_regulation ITGB2 MAPK4 12370241 1286613 Positive_regulation ITGB2 MAPK6 12370241 1286614 Positive_regulation ITGB2 MAPK7 12370241 1286615 Positive_regulation ITGB2 MAPK8 12370241 1286616 Positive_regulation ITGB2 MAPK9 12370241 1286617 Positive_regulation ITGB2 MCOLN1 9298996 1463454 Positive_regulation ITGB2 MMP9 11097210 702109 Positive_regulation ITGB2 MOK 19426472 525467 Positive_regulation ITGB2 MPO 23508943 906591 Positive_regulation ITGB2 MYL2 25133611 2998722 Positive_regulation ITGB2 NM 20119709 1644265 Positive_regulation ITGB2 NPY6R 16216891 1538068 Positive_regulation ITGB2 NRG1 18159252 2381633 Positive_regulation ITGB2 PAF1 1717478 1335499 Positive_regulation ITGB2 PAF1 18475624 1744918 Positive_regulation ITGB2 PAF1 18475624 1744919 Positive_regulation ITGB2 PAF1 19865173 1983952 Positive_regulation ITGB2 PAF1 25344627 1722476 Positive_regulation ITGB2 PDB1 2565948 1577436 Positive_regulation ITGB2 PDLIM7 24068937 3064205 Positive_regulation ITGB2 PIK3CA 22347375 2595749 Positive_regulation ITGB2 PIK3CA 23935932 2828518 Positive_regulation ITGB2 PIK3R1 22347375 2595750 Positive_regulation ITGB2 PIK3R1 23935932 2828519 Positive_regulation ITGB2 PLD1 22654882 901236 Positive_regulation ITGB2 POT1 17692468 157352 Positive_regulation ITGB2 POT1 20733035 1559630 Positive_regulation ITGB2 POT1 24376655 2901741 Positive_regulation ITGB2 PTBP1 21847125 437703 Positive_regulation ITGB2 PTBP2 21847125 437700 Positive_regulation ITGB2 RAB11A 22701657 2651612 Positive_regulation ITGB2 RAC1 21206905 2491099 Positive_regulation ITGB2 RAC1 21206905 2491137 Positive_regulation ITGB2 RAC1 22654882 901229 Positive_regulation ITGB2 RAC2 21206905 2491100 Positive_regulation ITGB2 RAC2 21206905 2491138 Positive_regulation ITGB2 RAD50 17692468 157355 Positive_regulation ITGB2 RAD50 20733035 1559633 Positive_regulation ITGB2 RAD50 24376655 2901744 Positive_regulation ITGB2 RASGRP2 17576779 1546534 Positive_regulation ITGB2 RHOA 22654882 901228 Positive_regulation ITGB2 RHOA 22654882 901235 Positive_regulation ITGB2 S100A9 12137245 1738160 Positive_regulation ITGB2 S100A9 12396471 1738252 Positive_regulation ITGB2 S100B 20827421 513007 Positive_regulation ITGB2 SELE 1315317 1297505 Positive_regulation ITGB2 SELE 1378450 1297954 Positive_regulation ITGB2 SELE 1378450 1297958 Positive_regulation ITGB2 SELE 1378450 1297959 Positive_regulation ITGB2 SELE 21835035 1626401 Positive_regulation ITGB2 SELE 23750158 907367 Positive_regulation ITGB2 SELL 11817675 1738025 Positive_regulation ITGB2 SELP 12208882 1524773 Positive_regulation ITGB2 SELPLG 23750158 907368 Positive_regulation ITGB2 SOD1 23959798 1880533 Positive_regulation ITGB2 SOD1 23959798 1880539 Positive_regulation ITGB2 SOD1 25423296 3030119 Positive_regulation ITGB2 SOD2 23959798 1880540 Positive_regulation ITGB2 SOD3 23959798 1880541 Positive_regulation ITGB2 SRC 12885870 1528147 Positive_regulation ITGB2 SRC 22110576 2572169 Positive_regulation ITGB2 SRC 22110576 2572245 Positive_regulation ITGB2 SRC 22496642 3056033 Positive_regulation ITGB2 STK4 25133611 2998721 Positive_regulation ITGB2 SYK 12885870 1528148 Positive_regulation ITGB2 SYK 22496642 3056034 Positive_regulation ITGB2 TAZ 20972459 2136515 Positive_regulation ITGB2 TERF1 17692468 157349 Positive_regulation ITGB2 TERF1 20733035 1559627 Positive_regulation ITGB2 TERF1 24376655 2901738 Positive_regulation ITGB2 TERF2 17692468 157350 Positive_regulation ITGB2 TERF2 20733035 1559628 Positive_regulation ITGB2 TERF2 24376655 2901739 Positive_regulation ITGB2 TERF2IP 17692468 157353 Positive_regulation ITGB2 TERF2IP 20733035 1559631 Positive_regulation ITGB2 TERF2IP 24376655 2901742 Positive_regulation ITGB2 TINF2 17692468 157351 Positive_regulation ITGB2 TINF2 20733035 1559629 Positive_regulation ITGB2 TINF2 24376655 2901740 Positive_regulation ITGB2 TLN1 22701459 901710 Positive_regulation ITGB2 TNF 18472868 1742308 Positive_regulation ITGB2 TNF 2165128 1564034 Positive_regulation ITGB2 TNF 21876832 1082212 Positive_regulation ITGB2 TNF 21970746 354724 Positive_regulation ITGB2 TNF 21970746 354729 Positive_regulation ITGB2 TNF 2565948 1577439 Positive_regulation ITGB2 TNF 8666673 1452090 Positive_regulation ITGB2 TRAF3IP2 22693444 3057067 Positive_regulation ITGB2 TRG 9836498 1764063 Positive_regulation ITGB2 VAV1 24368807 1413136 Positive_regulation ITGB2 WDR61 1717478 1335500 Positive_regulation ITGB2 WDR61 18475624 1744920 Positive_regulation ITGB2 WDR61 18475624 1744921 Positive_regulation ITGB2 WDR61 19865173 1983953 Positive_regulation ITGB2 WDR61 25344627 1722477 Positive_regulation ITGB2 YAP1 23857250 2156961 Positive_regulation ITGB2 ZAP70 12885870 1528149 Positive_regulation ITGB2 ZAP70 9732296 1470770 Positive_regulation ITGB2 ZAP70 9732296 1470771 Positive_regulation ITGB8 FAS 20953353 1748406 Positive_regulation ITIH4 MMP28 22132194 2574427 Positive_regulation ITIH4 MMP28 22132194 2574428 Positive_regulation ITIH4 MMP7 22132194 2574457 Positive_regulation ITIH4 MMP7 22132194 2574458 Positive_regulation ITIH4 TNF 23986795 2220469 Positive_regulation ITIH4 TNF 24278714 3150255 Positive_regulation ITM2B TNF 23987141 345026 Positive_regulation ITPR1 TNF 24056707 18481 Positive_regulation ITSN2 CDKN1C 23472054 2282152 Positive_regulation ITSN2 CDKN1C 23472054 2282172 Positive_regulation IVD MMP28 21801383 1652101 Positive_regulation IVL TGM2 2466642 795225 Positive_regulation JAG1 ANGPT2 24098521 2858066 Positive_regulation JAG1 BACE1 25591666 3149660 Positive_regulation JAG1 BMP6 21605425 404941 Positive_regulation JAG1 BRCA1 23863842 2091379 Positive_regulation JAG1 BRCA1 23863842 2091390 Positive_regulation JAG1 BRCA1 23863842 2091391 Positive_regulation JAG1 BRCA1 23863842 2091402 Positive_regulation JAG1 BRCA1 23863842 2091426 Positive_regulation JAG1 C19orf10 22692775 665257 Positive_regulation JAG1 CA2 24239355 609203 Positive_regulation JAG1 CCDC88A 25610519 3225773 Positive_regulation JAG1 CCND1 23554857 2773593 Positive_regulation JAG1 CCNT1 19015152 2037585 Positive_regulation JAG1 CD40 22829976 218101 Positive_regulation JAG1 CD46 23086448 1958066 Positive_regulation JAG1 CD46 23086448 1958243 Positive_regulation JAG1 CDK9 19015152 2037586 Positive_regulation JAG1 CSF2 22390640 124919 Positive_regulation JAG1 CTNNB1 23646120 2788098 Positive_regulation JAG1 DKC1 22351600 778084 Positive_regulation JAG1 DKC1 22351600 778085 Positive_regulation JAG1 DKC1 22351600 778098 Positive_regulation JAG1 DLL1 22390640 124920 Positive_regulation JAG1 DLL1 22558446 2626037 Positive_regulation JAG1 DLL3 22558446 2626038 Positive_regulation JAG1 DLL4 20016694 1160903 Positive_regulation JAG1 DLL4 22558446 2626039 Positive_regulation JAG1 EGF 23613900 2782725 Positive_regulation JAG1 EGF 23901284 2121524 Positive_regulation JAG1 EPHB2 25164432 1484768 Positive_regulation JAG1 ERF 23630463 866827 Positive_regulation JAG1 ERF 23630463 866829 Positive_regulation JAG1 EZR 20209125 2442278 Positive_regulation JAG1 FGF1 24465223 2355711 Positive_regulation JAG1 FGF10 24465223 2355712 Positive_regulation JAG1 FGF11 24465223 2355713 Positive_regulation JAG1 FGF12 24465223 2355714 Positive_regulation JAG1 FGF13 24465223 2355715 Positive_regulation JAG1 FGF14 24465223 2355716 Positive_regulation JAG1 FGF16 24465223 2355717 Positive_regulation JAG1 FGF17 24465223 2355718 Positive_regulation JAG1 FGF18 24465223 2355719 Positive_regulation JAG1 FGF19 24465223 2355720 Positive_regulation JAG1 FGF2 24465223 2355721 Positive_regulation JAG1 FGF20 24465223 2355722 Positive_regulation JAG1 FGF21 24465223 2355723 Positive_regulation JAG1 FGF22 24465223 2355724 Positive_regulation JAG1 FGF23 24465223 2355725 Positive_regulation JAG1 FGF3 24465223 2355726 Positive_regulation JAG1 FGF4 24465223 2355727 Positive_regulation JAG1 FGF5 24465223 2355728 Positive_regulation JAG1 FGF6 24465223 2355729 Positive_regulation JAG1 FGF7 24465223 2355730 Positive_regulation JAG1 FGF8 24465223 2355731 Positive_regulation JAG1 FGF9 24465223 2355732 Positive_regulation JAG1 GAST 23544109 2773470 Positive_regulation JAG1 GAST 23544109 2773471 Positive_regulation JAG1 GAST 25384047 3024712 Positive_regulation JAG1 GDF2 21764776 2065043 Positive_regulation JAG1 GDF2 21764776 2065084 Positive_regulation JAG1 GDF2 21764776 2065085 Positive_regulation JAG1 GDF2 24896812 2976223 Positive_regulation JAG1 GRM5 21547712 1653178 Positive_regulation JAG1 GRN 19015152 2037594 Positive_regulation JAG1 HES1 23704950 2797095 Positive_regulation JAG1 HES1 23773282 483503 Positive_regulation JAG1 HNRNPF 20479116 1558257 Positive_regulation JAG1 HNRNPH1 20479116 1558258 Positive_regulation JAG1 HSP90AA1 22351600 778086 Positive_regulation JAG1 HSP90AA1 22351600 778087 Positive_regulation JAG1 HSP90AA1 22351600 778099 Positive_regulation JAG1 ID4 21293053 2174736 Positive_regulation JAG1 IGFALS 25609923 744874 Positive_regulation JAG1 IL1A 15028114 312868 Positive_regulation JAG1 IL1A 23495140 780223 Positive_regulation JAG1 IL1A 23495140 780224 Positive_regulation JAG1 IL1A 23495140 780231 Positive_regulation JAG1 IL1A 23495140 780233 Positive_regulation JAG1 IL1A 23495140 780234 Positive_regulation JAG1 IL1A 23495140 780235 Positive_regulation JAG1 IL1A 24043949 2122028 Positive_regulation JAG1 IL1RN 23495140 780232 Positive_regulation JAG1 IL22 25303370 219396 Positive_regulation JAG1 IL6 23799116 2807133 Positive_regulation JAG1 IL6 PMC4070608 3206178 Positive_regulation JAG1 IL8 PMC4070608 3206179 Positive_regulation JAG1 KDM4A 24886710 475119 Positive_regulation JAG1 KLF4 21242971 2137448 Positive_regulation JAG1 MET 22110593 2572308 Positive_regulation JAG1 MFN2 23797661 1107812 Positive_regulation JAG1 MIR335 24885481 273337 Positive_regulation JAG1 MYLIP 21857907 2544264 Positive_regulation JAG1 MYLIP 21887253 2548874 Positive_regulation JAG1 MYLIP 21887253 2548875 Positive_regulation JAG1 MYLIP 22113133 469063 Positive_regulation JAG1 MYLIP 22363487 2599552 Positive_regulation JAG1 MYLIP 22363487 2599566 Positive_regulation JAG1 MYLIP 22363487 2599572 Positive_regulation JAG1 MYLIP 23768087 268938 Positive_regulation JAG1 MYLIP 24694752 3141347 Positive_regulation JAG1 MYLIP 25009466 869663 Positive_regulation JAG1 MYLIP 25018733 965452 Positive_regulation JAG1 NELFCD 19159481 1655614 Positive_regulation JAG1 NFKB1 19936191 667320 Positive_regulation JAG1 NFKB1 21843347 1229481 Positive_regulation JAG1 NOTCH1 10748227 1515058 Positive_regulation JAG1 NOTCH1 16604164 2013473 Positive_regulation JAG1 NOTCH1 17984306 1547606 Positive_regulation JAG1 NOTCH1 18194540 242222 Positive_regulation JAG1 NOTCH1 19015735 2400928 Positive_regulation JAG1 NOTCH1 20691079 257034 Positive_regulation JAG1 NOTCH1 21549007 259704 Positive_regulation JAG1 NOTCH1 22110751 2573270 Positive_regulation JAG1 NOTCH1 22390640 124861 Positive_regulation JAG1 NOTCH1 22390640 124862 Positive_regulation JAG1 NOTCH1 22487493 3207570 Positive_regulation JAG1 NOTCH1 22509166 957036 Positive_regulation JAG1 NOTCH1 22715413 2652997 Positive_regulation JAG1 NOTCH1 22937766 2236031 Positive_regulation JAG1 NOTCH1 23056328 2701187 Positive_regulation JAG1 NOTCH1 23086448 1958244 Positive_regulation JAG1 NOTCH1 23530123 1570920 Positive_regulation JAG1 NOTCH1 23533807 1154031 Positive_regulation JAG1 NOTCH1 23646120 2788099 Positive_regulation JAG1 NOTCH1 23759991 1107687 Positive_regulation JAG1 NOTCH1 24172068 474014 Positive_regulation JAG1 NOTCH1 24317268 1703497 Positive_regulation JAG1 NOTCH1 24465223 2355664 Positive_regulation JAG1 NOTCH1 24961530 452865 Positive_regulation JAG1 NOTCH1 25049796 136467 Positive_regulation JAG1 NOTCH2 16604164 2013474 Positive_regulation JAG1 NOTCH2 17984306 1547607 Positive_regulation JAG1 NOTCH2 19015735 2400929 Positive_regulation JAG1 NOTCH2 21549007 259705 Positive_regulation JAG1 NOTCH2 22110751 2573271 Positive_regulation JAG1 NOTCH2 22390640 124863 Positive_regulation JAG1 NOTCH2 22390640 124864 Positive_regulation JAG1 NOTCH2 22487493 3207571 Positive_regulation JAG1 NOTCH2 22509166 957037 Positive_regulation JAG1 NOTCH2 22715413 2652998 Positive_regulation JAG1 NOTCH2 22937766 2236032 Positive_regulation JAG1 NOTCH2 23056328 2701188 Positive_regulation JAG1 NOTCH2 23086448 1958245 Positive_regulation JAG1 NOTCH2 23530123 1570921 Positive_regulation JAG1 NOTCH2 23646120 2788100 Positive_regulation JAG1 NOTCH2 23759991 1107688 Positive_regulation JAG1 NOTCH2 24172068 474015 Positive_regulation JAG1 NOTCH2 24317268 1703498 Positive_regulation JAG1 NOTCH2 24465223 2355665 Positive_regulation JAG1 NOTCH2 24961530 452866 Positive_regulation JAG1 NOTCH2 25049796 136468 Positive_regulation JAG1 NOTCH3 16604164 2013475 Positive_regulation JAG1 NOTCH3 17984306 1547608 Positive_regulation JAG1 NOTCH3 19015735 2400930 Positive_regulation JAG1 NOTCH3 20953350 2174563 Positive_regulation JAG1 NOTCH3 20953350 2174564 Positive_regulation JAG1 NOTCH3 21193734 717025 Positive_regulation JAG1 NOTCH3 21549007 259706 Positive_regulation JAG1 NOTCH3 21549007 259712 Positive_regulation JAG1 NOTCH3 22087289 2571293 Positive_regulation JAG1 NOTCH3 22110751 2573272 Positive_regulation JAG1 NOTCH3 22487493 3207572 Positive_regulation JAG1 NOTCH3 22509166 957038 Positive_regulation JAG1 NOTCH3 22715413 2652999 Positive_regulation JAG1 NOTCH3 22937766 2236033 Positive_regulation JAG1 NOTCH3 23056328 2701189 Positive_regulation JAG1 NOTCH3 23086448 1958246 Positive_regulation JAG1 NOTCH3 23158439 358844 Positive_regulation JAG1 NOTCH3 23530123 1570922 Positive_regulation JAG1 NOTCH3 23646120 2788101 Positive_regulation JAG1 NOTCH3 23759991 1107689 Positive_regulation JAG1 NOTCH3 24172068 474016 Positive_regulation JAG1 NOTCH3 24317268 1703499 Positive_regulation JAG1 NOTCH3 24465223 2355666 Positive_regulation JAG1 NOTCH3 24961530 452867 Positive_regulation JAG1 NOTCH3 25049796 136469 Positive_regulation JAG1 NOTCH4 16604164 2013476 Positive_regulation JAG1 NOTCH4 17984306 1547609 Positive_regulation JAG1 NOTCH4 19015735 2400931 Positive_regulation JAG1 NOTCH4 21549007 259707 Positive_regulation JAG1 NOTCH4 22110751 2573273 Positive_regulation JAG1 NOTCH4 22487493 3207573 Positive_regulation JAG1 NOTCH4 22509166 957039 Positive_regulation JAG1 NOTCH4 22715413 2653000 Positive_regulation JAG1 NOTCH4 22937766 2236034 Positive_regulation JAG1 NOTCH4 23056328 2701190 Positive_regulation JAG1 NOTCH4 23086448 1958247 Positive_regulation JAG1 NOTCH4 23530123 1570923 Positive_regulation JAG1 NOTCH4 23646120 2788102 Positive_regulation JAG1 NOTCH4 23759991 1107690 Positive_regulation JAG1 NOTCH4 24172068 474017 Positive_regulation JAG1 NOTCH4 24317268 1703500 Positive_regulation JAG1 NOTCH4 24465223 2355667 Positive_regulation JAG1 NOTCH4 24961530 452868 Positive_regulation JAG1 NOTCH4 25049796 136470 Positive_regulation JAG1 NPS 24493925 1138179 Positive_regulation JAG1 NUMB 21122105 1996602 Positive_regulation JAG1 PML 23455394 1720914 Positive_regulation JAG1 PSENEN 23300864 2736335 Positive_regulation JAG1 PTBP1 20479116 1558259 Positive_regulation JAG1 PTBP2 20479116 1558256 Positive_regulation JAG1 PTGES3 22351600 778082 Positive_regulation JAG1 PTGES3 22351600 778083 Positive_regulation JAG1 PTGES3 22351600 778097 Positive_regulation JAG1 PTH 24198511 3172390 Positive_regulation JAG1 RARA 23455394 1720915 Positive_regulation JAG1 RBPJ 22249448 1566893 Positive_regulation JAG1 REL 22166355 1234871 Positive_regulation JAG1 RELA 19936191 667321 Positive_regulation JAG1 RELA 21843347 1229482 Positive_regulation JAG1 RELA 22166355 1234872 Positive_regulation JAG1 RNASE1 19015152 2037580 Positive_regulation JAG1 RNASE10 19015152 2037588 Positive_regulation JAG1 RNASE11 19015152 2037587 Positive_regulation JAG1 RNASE12 19015152 2037592 Positive_regulation JAG1 RNASE13 19015152 2037593 Positive_regulation JAG1 RNASE2 19015152 2037581 Positive_regulation JAG1 RNASE3 19015152 2037582 Positive_regulation JAG1 RNASE4 19015152 2037583 Positive_regulation JAG1 RNASE6 19015152 2037584 Positive_regulation JAG1 RNASE7 19015152 2037590 Positive_regulation JAG1 RNASE8 19015152 2037589 Positive_regulation JAG1 RNASE9 19015152 2037591 Positive_regulation JAG1 RNASEH1 23355612 2084939 Positive_regulation JAG1 RPL10 22943452 828041 Positive_regulation JAG1 RPL11 22943452 828042 Positive_regulation JAG1 RPL12 22943452 828043 Positive_regulation JAG1 RPL13 22943452 828044 Positive_regulation JAG1 RPL14 22943452 828045 Positive_regulation JAG1 RPL15 22943452 828046 Positive_regulation JAG1 RPL17 22943452 828047 Positive_regulation JAG1 RPL18 22943452 828048 Positive_regulation JAG1 RPL19 22943452 828049 Positive_regulation JAG1 RPL21 22943452 828050 Positive_regulation JAG1 RPL22 22943452 828051 Positive_regulation JAG1 RPL23 22943452 828052 Positive_regulation JAG1 RPL24 22943452 828053 Positive_regulation JAG1 RPL26 22943452 828054 Positive_regulation JAG1 RPL27 22943452 828055 Positive_regulation JAG1 RPL28 22943452 828056 Positive_regulation JAG1 RPL29 22943452 828057 Positive_regulation JAG1 RPL3 22943452 828058 Positive_regulation JAG1 RPL30 22943452 828059 Positive_regulation JAG1 RPL31 22943452 828060 Positive_regulation JAG1 RPL32 22943452 828061 Positive_regulation JAG1 RPL34 22943452 828062 Positive_regulation JAG1 RPL35 22943452 828063 Positive_regulation JAG1 RPL36 22943452 828074 Positive_regulation JAG1 RPL37 22943452 828064 Positive_regulation JAG1 RPL38 22943452 828065 Positive_regulation JAG1 RPL39 22943452 828066 Positive_regulation JAG1 RPL4 22943452 828067 Positive_regulation JAG1 RPL41 22943452 828068 Positive_regulation JAG1 RPL5 22943452 828069 Positive_regulation JAG1 RPL6 22943452 828070 Positive_regulation JAG1 RPL7 22943452 828071 Positive_regulation JAG1 RPL8 22943452 828072 Positive_regulation JAG1 RPL9 22943452 828073 Positive_regulation JAG1 SETD2 PMC4212306 3206363 Positive_regulation JAG1 SHH 19839776 1236850 Positive_regulation JAG1 SHH 19839776 1236867 Positive_regulation JAG1 SHH 19839776 1236892 Positive_regulation JAG1 SHH 23028429 2690510 Positive_regulation JAG1 SLC22A3 20098718 2438130 Positive_regulation JAG1 SMAD7 24791137 1916875 Positive_regulation JAG1 SNAI2 17984306 1547522 Positive_regulation JAG1 SNAI2 17984306 1547523 Positive_regulation JAG1 SNX17 25408867 608116 Positive_regulation JAG1 SNX17 25408867 608117 Positive_regulation JAG1 SNX17 25408867 608143 Positive_regulation JAG1 SNX17 25408867 608165 Positive_regulation JAG1 SNX17 25408867 608166 Positive_regulation JAG1 SNX17 25408867 608169 Positive_regulation JAG1 SNX17 25408867 608178 Positive_regulation JAG1 SOS1 23613664 2345445 Positive_regulation JAG1 SOS2 23613664 2345446 Positive_regulation JAG1 SOX2 24465223 2355663 Positive_regulation JAG1 TCF12 20150991 1161077 Positive_regulation JAG1 TCF15 20150991 1161078 Positive_regulation JAG1 TCF19 20150991 1161079 Positive_regulation JAG1 TCF20 20150991 1161080 Positive_regulation JAG1 TCF21 20150991 1161081 Positive_regulation JAG1 TCF23 20150991 1161085 Positive_regulation JAG1 TCF24 20150991 1161087 Positive_regulation JAG1 TCF25 20150991 1161086 Positive_regulation JAG1 TCF3 20150991 1161082 Positive_regulation JAG1 TCF4 20150991 1161083 Positive_regulation JAG1 TCF7 20150991 1161084 Positive_regulation JAG1 TCF7L2 21437251 2509044 Positive_regulation JAG1 TERT 22351600 778079 Positive_regulation JAG1 TERT 22351600 778080 Positive_regulation JAG1 TERT 22351600 778081 Positive_regulation JAG1 TERT 22351600 778096 Positive_regulation JAG1 TLR3 20436665 2448787 Positive_regulation JAG1 TLR4 20436665 2448794 Positive_regulation JAG1 TLR4 24810405 2962605 Positive_regulation JAG1 TNF 22249448 1566872 Positive_regulation JAG1 TNF 22487493 3207579 Positive_regulation JAG1 TNF 23531541 1103926 Positive_regulation JAG1 TNFSF11 24317268 1703506 Positive_regulation JAG1 TP53 24098521 2858041 Positive_regulation JAG1 TP53 24098521 2858067 Positive_regulation JAG1 TP53 24098521 2858073 Positive_regulation JAG1 UGCG 11015435 1517308 Positive_regulation JAG1 UGCG 23049531 904422 Positive_regulation JAG1 UVRAG 23863842 2091423 Positive_regulation JAG1 VEGFA 20016694 1160902 Positive_regulation JAG1 WNK1 24970818 2194437 Positive_regulation JAG1 WNT1 23646120 2788091 Positive_regulation JAG1 WNT1 23772628 1043005 Positive_regulation JAG1 WNT11 23646120 2788092 Positive_regulation JAG1 WNT11 23772628 1043006 Positive_regulation JAG1 WNT16 23646120 2788097 Positive_regulation JAG1 WNT16 23772628 1043011 Positive_regulation JAG1 WNT2 23646120 2788093 Positive_regulation JAG1 WNT2 23772628 1043007 Positive_regulation JAG1 WNT3 23646120 2788094 Positive_regulation JAG1 WNT3 23772628 1043008 Positive_regulation JAG1 WNT4 23646120 2788095 Positive_regulation JAG1 WNT4 23772628 1043009 Positive_regulation JAG1 WNT6 23646120 2788096 Positive_regulation JAG1 WNT6 23772628 1043010 Positive_regulation JAG2 JAG1 24708907 6073 Positive_regulation JAG2 TNF 22190977 633860 Positive_regulation JAG2 TNF 23531541 1103845 Positive_regulation JAK1 ABCA4 23847761 945773 Positive_regulation JAK1 CEACAM6 24069556 1706901 Positive_regulation JAK1 EPHB2 20030801 526450 Positive_regulation JAK1 EPHB2 24069558 1707287 Positive_regulation JAK1 GPR115 24662938 503230 Positive_regulation JAK1 GPR132 24662938 503219 Positive_regulation JAK1 GPR87 24662938 503299 Positive_regulation JAK1 ID1 22475005 174987 Positive_regulation JAK1 IL6R 24467886 474313 Positive_regulation JAK1 JAG1 24968269 1127929 Positive_regulation JAK1 MAP2K6 25254972 3069504 Positive_regulation JAK1 PLAU 23984088 1150908 Positive_regulation JAK1 TNF 22115362 212643 Positive_regulation JAK1 TNF 22351606 778146 Positive_regulation JAK1 TNF 24244348 2879532 Positive_regulation JAK1 TNF 25400510 1628054 Positive_regulation JAK2 CCND1 23382981 2747446 Positive_regulation JAK2 EDN2 22128240 1913124 Positive_regulation JAK2 EPHB2 20030801 526454 Positive_regulation JAK2 EPHB2 23216800 2113650 Positive_regulation JAK2 EPHB2 23469088 2761419 Positive_regulation JAK2 EPHB2 24069558 1707291 Positive_regulation JAK2 GPR115 24662938 503323 Positive_regulation JAK2 GPR132 24662938 503312 Positive_regulation JAK2 GPR87 24662938 503392 Positive_regulation JAK2 ID1 22475005 174988 Positive_regulation JAK2 IL6R 24467886 474315 Positive_regulation JAK2 JAG1 24968269 1127930 Positive_regulation JAK2 MAP2K6 25254972 3069515 Positive_regulation JAK2 RORC 24611151 588849 Positive_regulation JAK2 TLR7 20862390 979586 Positive_regulation JAK2 TNF 22115362 212644 Positive_regulation JAK2 TNF 22351606 778147 Positive_regulation JAK2 TNF 24244348 2879533 Positive_regulation JAK2 TNF 25400510 1628056 Positive_regulation JAK3 EPHB2 20030801 526458 Positive_regulation JAK3 EPHB2 24069558 1707298 Positive_regulation JAK3 GPR115 24662938 503417 Positive_regulation JAK3 GPR132 24662938 503406 Positive_regulation JAK3 GPR87 24662938 503486 Positive_regulation JAK3 ID1 22475005 174989 Positive_regulation JAK3 IL6R 24467886 474317 Positive_regulation JAK3 JAG1 24968269 1127931 Positive_regulation JAK3 MAP2K6 25254972 3069526 Positive_regulation JAK3 TNF 22115362 212645 Positive_regulation JAK3 TNF 22351606 778148 Positive_regulation JAK3 TNF 24244348 2879534 Positive_regulation JAK3 TNF 25400510 1628058 Positive_regulation JDP2 LGALS7B 23530091 2182812 Positive_regulation JPH2 CAPN8 24958777 1159850 Positive_regulation JUN CCND1 21179427 1912470 Positive_regulation JUN CCND1 23918007 2183994 Positive_regulation JUN CTGF 22212430 14235 Positive_regulation JUN CTGF 22212430 14236 Positive_regulation JUN CTGF 22212430 14254 Positive_regulation JUN CTGF 23227240 2725744 Positive_regulation JUN CTGF 23227240 2725750 Positive_regulation JUN CTGF 23227240 2725757 Positive_regulation JUN CTGF 23227240 2725758 Positive_regulation JUN CTGF 23681229 561789 Positive_regulation JUN CTGF 23681229 561806 Positive_regulation JUN EDN2 24265756 2885151 Positive_regulation JUN EPHB2 10648566 1255393 Positive_regulation JUN EPHB2 11457888 1519849 Positive_regulation JUN EPHB2 11506505 419685 Positive_regulation JUN EPHB2 12177047 1286336 Positive_regulation JUN EPHB2 15067018 1307766 Positive_regulation JUN EPHB2 15123736 1308403 Positive_regulation JUN EPHB2 15455051 1629452 Positive_regulation JUN EPHB2 16277698 104803 Positive_regulation JUN EPHB2 16464248 231821 Positive_regulation JUN EPHB2 17105652 106852 Positive_regulation JUN EPHB2 17940620 3228773 Positive_regulation JUN EPHB2 18983687 352496 Positive_regulation JUN EPHB2 19961337 1237254 Positive_regulation JUN EPHB2 20051107 365748 Positive_regulation JUN EPHB2 20802521 2135512 Positive_regulation JUN EPHB2 20858281 1859192 Positive_regulation JUN EPHB2 20858281 1859199 Positive_regulation JUN EPHB2 20858281 1859223 Positive_regulation JUN EPHB2 21258428 1030549 Positive_regulation JUN EPHB2 21345173 137727 Positive_regulation JUN EPHB2 21451502 1918231 Positive_regulation JUN EPHB2 21992677 1626429 Positive_regulation JUN EPHB2 22294553 777988 Positive_regulation JUN EPHB2 22384111 2604284 Positive_regulation JUN EPHB2 22384197 2607317 Positive_regulation JUN EPHB2 22675627 1688635 Positive_regulation JUN EPHB2 22969768 904233 Positive_regulation JUN EPHB2 23060802 959368 Positive_regulation JUN EPHB2 23082080 816032 Positive_regulation JUN EPHB2 23150750 2225186 Positive_regulation JUN EPHB2 23226069 2249757 Positive_regulation JUN EPHB2 23300995 2737821 Positive_regulation JUN EPHB2 23349788 2743153 Positive_regulation JUN EPHB2 23469214 2763279 Positive_regulation JUN EPHB2 23646205 2788772 Positive_regulation JUN EPHB2 23738035 2226040 Positive_regulation JUN EPHB2 23762330 2803033 Positive_regulation JUN EPHB2 23840429 2812812 Positive_regulation JUN EPHB2 23843873 821194 Positive_regulation JUN EPHB2 23912235 1109649 Positive_regulation JUN EPHB2 23929599 781625 Positive_regulation JUN EPHB2 23929599 781846 Positive_regulation JUN EPHB2 23946768 2165315 Positive_regulation JUN EPHB2 23946780 2165323 Positive_regulation JUN EPHB2 23946780 2165346 Positive_regulation JUN EPHB2 24086787 2372186 Positive_regulation JUN EPHB2 24116275 204256 Positive_regulation JUN EPHB2 24216995 500923 Positive_regulation JUN EPHB2 24278338 2885777 Positive_regulation JUN EPHB2 24312401 2889188 Positive_regulation JUN EPHB2 24416064 825081 Positive_regulation JUN EPHB2 24416064 825082 Positive_regulation JUN EPHB2 24736215 3223859 Positive_regulation JUN EPHB2 24739671 540390 Positive_regulation JUN EPHB2 24944898 1888038 Positive_regulation JUN EPHB2 24987712 1622189 Positive_regulation JUN EPHB2 25077945 2993616 Positive_regulation JUN EPHB2 25101306 1622640 Positive_regulation JUN EPHB2 25101306 1622641 Positive_regulation JUN EPHB2 25121739 2997342 Positive_regulation JUN EPHB2 25250890 3010045 Positive_regulation JUN EPHB2 8089186 1444670 Positive_regulation JUN EPHB2 8642312 1596847 Positive_regulation JUN EPHB2 PMC4036659 2246431 Positive_regulation JUN F2R 24385683 1756410 Positive_regulation JUN FAS 23029562 2698817 Positive_regulation JUN FAS 23760585 945437 Positive_regulation JUN FAS 24058807 1706253 Positive_regulation JUN FOXO1 23675967 536248 Positive_regulation JUN FOXO1 24633305 1963970 Positive_regulation JUN IFI27 24976536 1483670 Positive_regulation JUN IFI27 24976536 1483694 Positive_regulation JUN IL1B 18472873 1742426 Positive_regulation JUN IRS4 19539371 1718773 Positive_regulation JUN MAP2K6 15067018 1307695 Positive_regulation JUN MAP2K6 16390551 3106010 Positive_regulation JUN MAP2K6 22294553 777994 Positive_regulation JUN MAP2K6 23150750 2225192 Positive_regulation JUN MAP2K6 23929599 781631 Positive_regulation JUN MAP2K6 23936765 946067 Positive_regulation JUN MAP2K6 24116275 204262 Positive_regulation JUN MAP2K6 24671046 3141199 Positive_regulation JUN MMP28 15770046 1739815 Positive_regulation JUN MMP28 24212934 499140 Positive_regulation JUN MMP28 24976858 1650861 Positive_regulation JUN MMP28 25205949 90028 Positive_regulation JUN MMP7 15770046 1739830 Positive_regulation JUN MMP7 24212934 499158 Positive_regulation JUN MMP7 24976858 1650876 Positive_regulation JUN MMP7 25205949 90043 Positive_regulation JUN S100A7 20955608 585864 Positive_regulation JUN S100B 19292913 1695981 Positive_regulation JUN S100B 19292913 1695987 Positive_regulation JUN S100B 20862385 513136 Positive_regulation JUN SPRR3 24796531 2960565 Positive_regulation JUN SYNM 21776245 1075809 Positive_regulation JUN TLR7 12925671 1528211 Positive_regulation JUN TLR7 19668221 1952709 Positive_regulation JUN TLR7 19668221 1952710 Positive_regulation JUN TLR7 19668221 1952823 Positive_regulation JUN TLR7 19682366 326184 Positive_regulation JUN TLR7 21390243 1049717 Positive_regulation JUN TMPRSS4 24748857 1021867 Positive_regulation JUN TNF 10359574 1511807 Positive_regulation JUN TNF 10359574 1511808 Positive_regulation JUN TNF 10974006 1262670 Positive_regulation JUN TNF 10974006 1262671 Positive_regulation JUN TNF 11684708 1275857 Positive_regulation JUN TNF 12110129 99059 Positive_regulation JUN TNF 12110129 99062 Positive_regulation JUN TNF 12366867 350318 Positive_regulation JUN TNF 14624679 658498 Positive_regulation JUN TNF 15043753 3095696 Positive_regulation JUN TNF 15987479 103927 Positive_regulation JUN TNF 16359550 3105941 Positive_regulation JUN TNF 16359550 3105942 Positive_regulation JUN TNF 16359550 3105949 Positive_regulation JUN TNF 16606437 658630 Positive_regulation JUN TNF 17498300 401109 Positive_regulation JUN TNF 18341691 3108813 Positive_regulation JUN TNF 18341691 3108814 Positive_regulation JUN TNF 18341691 3108857 Positive_regulation JUN TNF 18341691 3108861 Positive_regulation JUN TNF 18472873 1742425 Positive_regulation JUN TNF 18687144 323981 Positive_regulation JUN TNF 19000313 390647 Positive_regulation JUN TNF 19281093 1071726 Positive_regulation JUN TNF 19292913 1695988 Positive_regulation JUN TNF 19473519 1227128 Positive_regulation JUN TNF 19473519 1227142 Positive_regulation JUN TNF 19473519 1227149 Positive_regulation JUN TNF 19723340 1227340 Positive_regulation JUN TNF 19723340 1227343 Positive_regulation JUN TNF 20011512 2433220 Positive_regulation JUN TNF 20406462 1853947 Positive_regulation JUN TNF 20418897 9883 Positive_regulation JUN TNF 20418897 9898 Positive_regulation JUN TNF 20936779 1964429 Positive_regulation JUN TNF 20979618 3213358 Positive_regulation JUN TNF 21115689 1562091 Positive_regulation JUN TNF 21115689 1562092 Positive_regulation JUN TNF 21345249 121579 Positive_regulation JUN TNF 21542902 1229082 Positive_regulation JUN TNF 21837268 1082178 Positive_regulation JUN TNF 22096345 1628244 Positive_regulation JUN TNF 22235182 3152436 Positive_regulation JUN TNF 22313861 3160921 Positive_regulation JUN TNF 22359588 2597978 Positive_regulation JUN TNF 22618772 722985 Positive_regulation JUN TNF 22649286 3153529 Positive_regulation JUN TNF 22768286 2660439 Positive_regulation JUN TNF 23002036 724855 Positive_regulation JUN TNF 23072510 126987 Positive_regulation JUN TNF 23072510 127028 Positive_regulation JUN TNF 23072510 127031 Positive_regulation JUN TNF 23272249 2730243 Positive_regulation JUN TNF 23437179 2755911 Positive_regulation JUN TNF 23482819 89197 Positive_regulation JUN TNF 23577023 3076678 Positive_regulation JUN TNF 23696882 2795773 Positive_regulation JUN TNF 23762091 637747 Positive_regulation JUN TNF 23784308 606101 Positive_regulation JUN TNF 23784308 606161 Positive_regulation JUN TNF 23844119 2819459 Positive_regulation JUN TNF 24004852 803472 Positive_regulation JUN TNF 24069158 2851339 Positive_regulation JUN TNF 24069158 2851490 Positive_regulation JUN TNF 24069158 2851519 Positive_regulation JUN TNF 24069158 2851537 Positive_regulation JUN TNF 24069158 2851604 Positive_regulation JUN TNF 24069158 2851605 Positive_regulation JUN TNF 24069158 2851643 Positive_regulation JUN TNF 24069158 2851668 Positive_regulation JUN TNF 24198657 1614417 Positive_regulation JUN TNF 24256769 1700941 Positive_regulation JUN TNF 24256769 1700942 Positive_regulation JUN TNF 24256769 1700943 Positive_regulation JUN TNF 24256769 1700945 Positive_regulation JUN TNF 24307884 3155506 Positive_regulation JUN TNF 24423080 538869 Positive_regulation JUN TNF 24516606 2921183 Positive_regulation JUN TNF 24587316 2929421 Positive_regulation JUN TNF 24587316 2929422 Positive_regulation JUN TNF 24587316 2929428 Positive_regulation JUN TNF 24595242 1124982 Positive_regulation JUN TNF 24660115 3126263 Positive_regulation JUN TNF 24707477 188307 Positive_regulation JUN TNF 24707477 188431 Positive_regulation JUN TNF 24707477 188460 Positive_regulation JUN TNF 24707477 188461 Positive_regulation JUN TNF 25009774 3094511 Positive_regulation JUN TNF 25116848 2118925 Positive_regulation JUN TNF 25215307 1623260 Positive_regulation JUN TNF 25337566 1241529 Positive_regulation JUN TNF 25526629 3035137 Positive_regulation JUN TNF 25552899 743713 Positive_regulation JUN TNF 8691131 1598157 Positive_regulation JUN TNF 8691131 1598226 Positive_regulation JUN TNF 8922393 1457847 Positive_regulation JUN TNF 9788898 798144 Positive_regulation JUN TNF PMC2833605 134239 Positive_regulation JUNB EPHB2 10648566 1255395 Positive_regulation JUNB EPHB2 22443687 291878 Positive_regulation JUNB FOXO1 20921137 1380140 Positive_regulation JUNB MAP2K6 22852078 1689209 Positive_regulation JUNB TNF 15142264 101176 Positive_regulation JUNB TNF 23328670 558966 Positive_regulation JUND EPHB2 17940620 3228775 Positive_regulation JUND EPHB2 20051107 365751 Positive_regulation JUND TNF 15142264 101177 Positive_regulation JUP CHI3L1 23665676 2152222 Positive_regulation JUP TSPAN1 14691142 1303070 Positive_regulation JUP TSPAN1 14691142 1303071 Positive_regulation KAL1 PLAU 24189182 787854 Positive_regulation KALRN EPHB2 24851087 685304 Positive_regulation KANK4 AKT1 18458160 1351959 Positive_regulation KANK4 AKT2 18458160 1351960 Positive_regulation KANK4 AKT3 18458160 1351961 Positive_regulation KANK4 BAIAP2 19171758 1363651 Positive_regulation KANK4 BAIAP2 19171758 1363655 Positive_regulation KANK4 COX7A2L 25203404 3006367 Positive_regulation KANK4 EGF 18458160 1352083 Positive_regulation KANK4 INS 18458160 1352084 Positive_regulation KANK4 PIK3CA 18458160 1351962 Positive_regulation KANK4 PIK3R1 18458160 1351963 Positive_regulation KARS TNF 24312579 2889883 Positive_regulation KAT2B FOXA1 22125492 2327877 Positive_regulation KAT2B FOXA1 24073287 2853730 Positive_regulation KAT2B FOXA1 24073287 2853733 Positive_regulation KAT2B IFI27 22547391 2074911 Positive_regulation KAT2B IFI27 22547391 2074926 Positive_regulation KAT2B TGM2 22944909 1890295 Positive_regulation KAT2B TLR7 22216977 1660630 Positive_regulation KAT2B TLR7 22312110 1567193 Positive_regulation KAT2B TLR7 22312110 1567194 Positive_regulation KAT2B TLR7 22312110 1567262 Positive_regulation KAT2B TLR7 22388040 1956598 Positive_regulation KAT2B TLR7 23525517 2162341 Positive_regulation KAT2B TNF 19052667 162863 Positive_regulation KCNE1 MYLIP 24386485 2904023 Positive_regulation KCNE1 P2RY4 16266433 524650 Positive_regulation KCNH2 KRT38 18648544 2393734 Positive_regulation KCNH2 PODXL 18648544 2393741 Positive_regulation KCNH4 EPHB2 14707112 1530537 Positive_regulation KCNH4 EPHB2 17664338 1342593 Positive_regulation KCNH4 EPHB2 19917132 385863 Positive_regulation KCNH4 EPHB2 19960006 8359 Positive_regulation KCNH4 EPHB2 20137095 375081 Positive_regulation KCNH4 EPHB2 21441990 936228 Positive_regulation KCNH4 EPHB2 21441990 936237 Positive_regulation KCNH4 EPHB2 21655091 2324656 Positive_regulation KCNH4 EPHB2 21655091 2324676 Positive_regulation KCNH4 EPHB2 21655091 2324705 Positive_regulation KCNH4 EPHB2 21655091 2324708 Positive_regulation KCNH4 EPHB2 24130510 2352017 Positive_regulation KCNH4 EPHB2 24386331 2903481 Positive_regulation KCNH4 EPHB2 24849319 2972486 Positive_regulation KCNH4 EPHB2 25569773 2368072 Positive_regulation KCNH4 MAP2K6 21960960 933838 Positive_regulation KCNH4 TNF 24386331 2903631 Positive_regulation KCNH8 EPHB2 10587355 1513542 Positive_regulation KCNH8 EPHB2 11309409 1269486 Positive_regulation KCNH8 EPHB2 12204819 791196 Positive_regulation KCNH8 EPHB2 17940620 3228771 Positive_regulation KCNH8 MAP2K6 21441990 936251 Positive_regulation KCNK3 EFTUD1 23497279 268039 Positive_regulation KCNK3 GABBR1 21569387 1229093 Positive_regulation KCNK3 GABBR2 21569387 1229094 Positive_regulation KCNK3 STX6 24743596 1823354 Positive_regulation KCNK3 VAMP3 24743596 1823355 Positive_regulation KCNK3 VTI1A 24743596 1823356 Positive_regulation KCNMA1 RORC 24129162 1920098 Positive_regulation KCNMA1 TNF 24129162 1920095 Positive_regulation KCNN4 EPHB2 25071444 869864 Positive_regulation KCNN4 MAP2K6 25071444 869853 Positive_regulation KCNN4 MAP2K6 25071444 869860 Positive_regulation KCNN4 MAP2K6 25071444 869872 Positive_regulation KCNN4 TLR7 20808895 3048433 Positive_regulation KCNQ1 KCNE1 21576273 1682631 Positive_regulation KCNQ1 KCNE1 22529812 951567 Positive_regulation KCNQ1 KCNE1 24478792 885754 Positive_regulation KCNQ1OT1 CDKN1C 23243085 1641312 Positive_regulation KCTD10 TNF 25401743 3027717 Positive_regulation KCTD10 TNF 25401743 3027788 Positive_regulation KDM1A PGC 22453831 1933607 Positive_regulation KDR CHI3L1 24883044 484404 Positive_regulation KDR EPHB2 19478883 2290545 Positive_regulation KDR EPHB2 23286511 587789 Positive_regulation KDR EPHB2 23286511 587790 Positive_regulation KDR EPHB2 23573229 2777928 Positive_regulation KDR EPHB2 23803732 543640 Positive_regulation KDR MMP28 25226613 2200016 Positive_regulation KDR MMP7 25226613 2200031 Positive_regulation KDR PECAM1 23776627 2805303 Positive_regulation KDR RCAN1 20625401 2454993 Positive_regulation KDR TNF 16277668 104594 Positive_regulation KDR TNF 16277668 104604 Positive_regulation KDR TNF 16277668 104609 Positive_regulation KDR TNF 16872509 3107476 Positive_regulation KDR TNF 24101875 629882 Positive_regulation KFM FAS 23634948 1726072 Positive_regulation KHDRBS1 EPHB2 18183298 2382386 Positive_regulation KHDRBS1 EPHB2 24287914 1121855 Positive_regulation KHDRBS1 EPHB2 24287914 1121865 Positive_regulation KHDRBS1 EPHB2 24830689 137141 Positive_regulation KHDRBS1 RNASE1 17371836 1338411 Positive_regulation KHDRBS1 RNASE7 17371836 1338419 Positive_regulation KHSRP TNF 19570027 137299 Positive_regulation KHSRP TNF 19570027 137472 Positive_regulation KHSRP TNF 22615562 3056745 Positive_regulation KHSRP TNF 22615562 3056762 Positive_regulation KHSRP TNF 24086143 2350912 Positive_regulation KIF11 RAB31 19653898 1833660 Positive_regulation KIF12 RAB31 19653898 1833579 Positive_regulation KIF14 RAB31 19653898 1833498 Positive_regulation KIF15 RAB31 19653898 1833417 Positive_regulation KIF17 RAB31 19653898 1833471 Positive_regulation KIF19 RAB31 19653898 1833606 Positive_regulation KIF1A RAB31 19653898 1833795 Positive_regulation KIF1A SYT8 22808098 2664551 Positive_regulation KIF22 RAB31 19653898 1833714 Positive_regulation KIF23 RAB31 19653898 1833741 Positive_regulation KIF24 RAB31 19653898 1833525 Positive_regulation KIF25 RAB31 19653898 1833687 Positive_regulation KIF27 RAB31 19653898 1833444 Positive_regulation KIF3A AXIN2 22473005 610593 Positive_regulation KIF6 RAB31 19653898 1833552 Positive_regulation KIF7 RAB31 19653898 1833633 Positive_regulation KIF9 RAB31 19653898 1833390 Positive_regulation KIN CCND1 25120685 2169296 Positive_regulation KIN IFI27 25120685 2169298 Positive_regulation KIR3DL1 FOXO1 22400069 2608787 Positive_regulation KIR3DL1 TLR7 21860586 1222467 Positive_regulation KIT EPHB2 24744103 494522 Positive_regulation KITLG IFI27 10555750 415539 Positive_regulation KITLG TNF 25062998 1620058 Positive_regulation KL EPHB2 24695641 2948297 Positive_regulation KL FOXO1 20844314 27695 Positive_regulation KLC1 TNF 10851018 1258311 Positive_regulation KLC1 TNF 10851018 1258313 Positive_regulation KLC1 TNF 10851018 1258429 Positive_regulation KLC2 TNF 10851018 1258308 Positive_regulation KLC2 TNF 10851018 1258312 Positive_regulation KLC2 TNF 10851018 1258426 Positive_regulation KLC3 TNF 10851018 1258309 Positive_regulation KLC3 TNF 10851018 1258427 Positive_regulation KLC4 TNF 10851018 1258310 Positive_regulation KLC4 TNF 10851018 1258428 Positive_regulation KLF2 FOXO1 20948623 846324 Positive_regulation KLF2 FOXO1 22563336 1709965 Positive_regulation KLF2 FOXO1 24155966 2871815 Positive_regulation KLF2 FOXO1 24155966 2871832 Positive_regulation KLF2 FOXO1 24162775 1959285 Positive_regulation KLF2 FOXO1 24996903 3124999 Positive_regulation KLF4 CCND1 23344177 1905725 Positive_regulation KLF4 TNF 25473217 88432 Positive_regulation KLF5 CCND1 20037604 8683 Positive_regulation KLF5 EGLN3 22905089 2675268 Positive_regulation KLF5 MAP2K6 19390590 2414860 Positive_regulation KLF8 EPHB2 21887232 2548000 Positive_regulation KLF9 MYLIP 24349493 2898351 Positive_regulation KLF9 NR2F1 24349493 2898337 Positive_regulation KLF9 NR2F1 24349493 2898347 Positive_regulation KLF9 NR2F1 24349493 2898352 Positive_regulation KLHDC7B TNF 22590687 3221123 Positive_regulation KLHDC7B TNF 25565867 2123745 Positive_regulation KLK3 ARSA 22566901 899728 Positive_regulation KLK3 EPHB2 22046506 1686732 Positive_regulation KLK3 FOXA1 24875621 1942336 Positive_regulation KLK3 MMP7 23658864 3225871 Positive_regulation KLK3 SPHK1 19956567 2432081 Positive_regulation KLK4 MMP28 23451143 2758228 Positive_regulation KLK4 MMP7 23451143 2758243 Positive_regulation KLK4 PLAU 23451143 2758249 Positive_regulation KLK5 TNF 19414552 1554726 Positive_regulation KLKB1 TNF 12110127 99044 Positive_regulation KLRAP1 PLAU 25310588 3015098 Positive_regulation KLRAP1 STAT4 25329659 3069672 Positive_regulation KLRB1 RORC 24223933 2877409 Positive_regulation KLRC1 ALOX5 19237603 1554197 Positive_regulation KLRC1 TNF 16507118 104966 Positive_regulation KLRC1 TNF 19409079 113164 Positive_regulation KLRC1 TNF 23505535 2766772 Positive_regulation KMT2A ALOX5 25402609 2160738 Positive_regulation KMT2A FOXA1 24288367 2096302 Positive_regulation KNG1 F3 632748 1585725 Positive_regulation KNTC1 CCND1 20072636 1670905 Positive_regulation KPNA3 EPHB2 21087211 148189 Positive_regulation KRAS CD14 20150966 1213526 Positive_regulation KRAS DGKI 25233099 3008239 Positive_regulation KRAS DGKI 25233099 3008246 Positive_regulation KRAS EFNB1 24868497 3179262 Positive_regulation KRAS EPHB2 17498287 999305 Positive_regulation KRAS EPHB2 18404483 3088057 Positive_regulation KRAS EPHB2 18463697 2289745 Positive_regulation KRAS EPHB2 19015320 1361498 Positive_regulation KRAS EPHB2 19652721 2422717 Positive_regulation KRAS EPHB2 19682393 1646625 Positive_regulation KRAS EPHB2 19826415 2127390 Positive_regulation KRAS EPHB2 21980390 2560147 Positive_regulation KRAS EPHB2 22319531 1067183 Positive_regulation KRAS EPHB2 22384111 2604080 Positive_regulation KRAS EPHB2 22567280 622850 Positive_regulation KRAS EPHB2 23060802 959304 Positive_regulation KRAS EPHB2 23617883 1867941 Positive_regulation KRAS EPHB2 23825558 2809641 Positive_regulation KRAS EPHB2 23908058 3227813 Positive_regulation KRAS EPHB2 23908058 3227814 Positive_regulation KRAS EPHB2 23908058 3227885 Positive_regulation KRAS EPHB2 24071646 566658 Positive_regulation KRAS EPHB2 24141185 1113552 Positive_regulation KRAS EPHB2 24330074 1482218 Positive_regulation KRAS EPHB2 24684778 1873593 Positive_regulation KRAS EPHB2 24743024 2189220 Positive_regulation KRAS EPHB2 24761768 273035 Positive_regulation KRAS EPHB2 24943349 365049 Positive_regulation KRAS EPHB2 24957684 2232041 Positive_regulation KRAS EPHB2 24994118 2194894 Positive_regulation KRAS EPHB2 25003010 3092919 Positive_regulation KRAS FOXA1 24073287 2853735 Positive_regulation KRAS FOXA1 24073287 2853741 Positive_regulation KRAS FOXO1 20375467 26945 Positive_regulation KRAS FOXO1 24265619 962915 Positive_regulation KRAS HBEGF 23888518 3185328 Positive_regulation KRAS LBP 20150966 1213527 Positive_regulation KRAS MAP2K6 17498287 999311 Positive_regulation KRAS MAP2K6 17892597 1645765 Positive_regulation KRAS MAP2K6 21072183 2481281 Positive_regulation KRAS MAP2K6 21307646 2223272 Positive_regulation KRAS MAP2K6 21307646 2223593 Positive_regulation KRAS MAP2K6 22384111 2604086 Positive_regulation KRAS MAP2K6 23060802 959310 Positive_regulation KRAS MAP2K6 23825558 2809647 Positive_regulation KRAS MAP2K6 23908058 3227825 Positive_regulation KRAS MAP2K6 23908058 3227826 Positive_regulation KRAS MAP2K6 23908058 3227891 Positive_regulation KRAS MAP2K6 24684778 1873599 Positive_regulation KRAS NGFR 25243118 199114 Positive_regulation KRAS PLAU 24971065 965307 Positive_regulation KRAS RASSF10 22500174 1067485 Positive_regulation KRAS TNF 24058780 1705541 Positive_regulation KRR1 FAS 21423395 955220 Positive_regulation KRR1 FAS 24336086 570501 Positive_regulation KRR1 TNF 19373245 546130 Positive_regulation KRR1 TNF 21670490 2176161 Positive_regulation KRR1 TNF 22297296 554147 Positive_regulation KRR1 TNF 23104095 1958271 Positive_regulation KRR1 TNF 23760205 605929 Positive_regulation KRR1 TNF 23835476 611275 Positive_regulation KRR1 TNF 24328763 451541 Positive_regulation KRR1 TNF 24876678 1759075 Positive_regulation KRR1 TNF 24959724 2983185 Positive_regulation KRR1 TNF 24991764 576779 Positive_regulation KRR1 TNF 25025000 1235446 Positive_regulation KRR1 TNFSF10 23096115 557874 Positive_regulation KRT1 FLG 21267458 2495512 Positive_regulation KRT1 TGM2 24278578 3180138 Positive_regulation KRT1 TP63 20808887 2317846 Positive_regulation KRT10 FLG 21267458 2495513 Positive_regulation KRT10 TGM2 24278578 3180140 Positive_regulation KRT12 FLG 21267458 2495514 Positive_regulation KRT12 TGM2 24278578 3180142 Positive_regulation KRT13 FLG 21267458 2495515 Positive_regulation KRT13 TGM2 24278578 3180144 Positive_regulation KRT14 FLG 21267458 2495516 Positive_regulation KRT14 MAOA 19691856 362359 Positive_regulation KRT14 MAOA 20805891 2471592 Positive_regulation KRT14 TGM2 24278578 3180146 Positive_regulation KRT15 FLG 21267458 2495517 Positive_regulation KRT15 TGM2 24278578 3180148 Positive_regulation KRT16 FLG 21267458 2495518 Positive_regulation KRT16 TGM2 24278578 3180150 Positive_regulation KRT16 TNF 17074928 1543106 Positive_regulation KRT17 FLG 21267458 2495519 Positive_regulation KRT17 TGM2 24278578 3180152 Positive_regulation KRT18 EMP1 16685278 427680 Positive_regulation KRT18 EMP1 16685278 427681 Positive_regulation KRT18 FLG 21267458 2495520 Positive_regulation KRT18 TGM2 24278578 3180154 Positive_regulation KRT19 FLG 21267458 2495521 Positive_regulation KRT19 TGM2 24278578 3180156 Positive_regulation KRT2 FLG 21267458 2495523 Positive_regulation KRT2 TGM2 24278578 3180160 Positive_regulation KRT20 FLG 21267458 2495495 Positive_regulation KRT20 TGM2 24278578 3180104 Positive_regulation KRT222 FLG 21267458 2495500 Positive_regulation KRT222 TGM2 24278578 3180114 Positive_regulation KRT23 FLG 21267458 2495522 Positive_regulation KRT23 TGM2 24278578 3180158 Positive_regulation KRT24 FLG 21267458 2495493 Positive_regulation KRT24 TGM2 24278578 3180100 Positive_regulation KRT25 FLG 21267458 2495507 Positive_regulation KRT25 TGM2 24278578 3180128 Positive_regulation KRT26 FLG 21267458 2495508 Positive_regulation KRT26 TGM2 24278578 3180130 Positive_regulation KRT27 FLG 21267458 2495509 Positive_regulation KRT27 TGM2 24278578 3180132 Positive_regulation KRT28 FLG 21267458 2495510 Positive_regulation KRT28 TGM2 24278578 3180134 Positive_regulation KRT3 FLG 21267458 2495524 Positive_regulation KRT3 TGM2 24278578 3180162 Positive_regulation KRT31 FLG 21267458 2495530 Positive_regulation KRT31 TGM2 24278578 3180174 Positive_regulation KRT32 FLG 21267458 2495531 Positive_regulation KRT32 TGM2 24278578 3180176 Positive_regulation KRT34 FLG 21267458 2495532 Positive_regulation KRT34 TGM2 24278578 3180178 Positive_regulation KRT35 FLG 21267458 2495533 Positive_regulation KRT35 RIC3 20522555 1188068 Positive_regulation KRT35 TGM2 24278578 3180180 Positive_regulation KRT36 FLG 21267458 2495534 Positive_regulation KRT36 TGM2 24278578 3180182 Positive_regulation KRT37 FLG 21267458 2495535 Positive_regulation KRT37 TGM2 24278578 3180184 Positive_regulation KRT38 ADIPOQ 23096717 1631460 Positive_regulation KRT38 ADIPOQ 23096717 1631560 Positive_regulation KRT38 AHSA1 17535969 1340584 Positive_regulation KRT38 AHSA1 17535969 1340635 Positive_regulation KRT38 DAPK2 23166623 2718191 Positive_regulation KRT38 DNAJB1 23650580 851792 Positive_regulation KRT38 EGF 2447102 1415646 Positive_regulation KRT38 EGFR 17178906 1335715 Positive_regulation KRT38 EIF3K 22590572 2641663 Positive_regulation KRT38 ELL 23565276 2777724 Positive_regulation KRT38 FLCN 23139756 2713862 Positive_regulation KRT38 FLG 21267458 2495536 Positive_regulation KRT38 FLI1 18648544 2393790 Positive_regulation KRT38 FOXN1 22808421 3131056 Positive_regulation KRT38 FOXN1 23696871 2795696 Positive_regulation KRT38 GAL 20582323 2271952 Positive_regulation KRT38 IFNG 23130241 1043769 Positive_regulation KRT38 KCNH2 18648544 2393791 Positive_regulation KRT38 KRT6B 2459129 1416825 Positive_regulation KRT38 MBS1 16365160 1326054 Positive_regulation KRT38 MYLIP 24451143 1123341 Positive_regulation KRT38 PRL 24853682 1050112 Positive_regulation KRT38 RNF19A 17535969 1340685 Positive_regulation KRT38 SFTPC 24244820 204953 Positive_regulation KRT38 SFTPC 24244820 205055 Positive_regulation KRT38 SFTPC 24278578 3180185 Positive_regulation KRT38 SFTPC 24278578 3180292 Positive_regulation KRT38 SOAT1 7500028 1588358 Positive_regulation KRT38 TCEA1 23565276 2777723 Positive_regulation KRT38 TCF12 24965658 3143241 Positive_regulation KRT38 TCF12 7500028 1588359 Positive_regulation KRT38 TCF15 24965658 3143242 Positive_regulation KRT38 TCF15 7500028 1588360 Positive_regulation KRT38 TCF19 24965658 3143243 Positive_regulation KRT38 TCF19 7500028 1588361 Positive_regulation KRT38 TCF20 24965658 3143244 Positive_regulation KRT38 TCF20 7500028 1588362 Positive_regulation KRT38 TCF21 24965658 3143245 Positive_regulation KRT38 TCF21 7500028 1588363 Positive_regulation KRT38 TCF23 24965658 3143249 Positive_regulation KRT38 TCF23 7500028 1588367 Positive_regulation KRT38 TCF24 24965658 3143251 Positive_regulation KRT38 TCF24 7500028 1588369 Positive_regulation KRT38 TCF25 24965658 3143250 Positive_regulation KRT38 TCF25 7500028 1588368 Positive_regulation KRT38 TCF3 24965658 3143246 Positive_regulation KRT38 TCF3 7500028 1588364 Positive_regulation KRT38 TCF4 24965658 3143247 Positive_regulation KRT38 TCF4 7500028 1588365 Positive_regulation KRT38 TCF7 24965658 3143248 Positive_regulation KRT38 TCF7 7500028 1588366 Positive_regulation KRT38 TGM2 24278578 3180186 Positive_regulation KRT38 TRH 24023889 2844082 Positive_regulation KRT38 TRIM4 21977036 1086023 Positive_regulation KRT38 VIM 1710225 1334765 Positive_regulation KRT38 WNT1 14610062 1300839 Positive_regulation KRT38 WNT11 14610062 1300840 Positive_regulation KRT38 WNT16 14610062 1300845 Positive_regulation KRT38 WNT2 14610062 1300841 Positive_regulation KRT38 WNT3 14610062 1300842 Positive_regulation KRT38 WNT4 14610062 1300843 Positive_regulation KRT38 WNT6 14610062 1300844 Positive_regulation KRT39 FLG 21267458 2495511 Positive_regulation KRT39 TGM2 24278578 3180136 Positive_regulation KRT4 FLG 21267458 2495525 Positive_regulation KRT4 TGM2 24278578 3180164 Positive_regulation KRT40 FLG 21267458 2495498 Positive_regulation KRT40 TGM2 24278578 3180110 Positive_regulation KRT5 FLG 21267458 2495526 Positive_regulation KRT5 TGM2 24278578 3180166 Positive_regulation KRT7 FLG 21267458 2495527 Positive_regulation KRT7 TGM2 24278578 3180168 Positive_regulation KRT71 FLG 21267458 2495502 Positive_regulation KRT71 TGM2 24278578 3180118 Positive_regulation KRT72 FLG 21267458 2495506 Positive_regulation KRT72 TGM2 24278578 3180126 Positive_regulation KRT73 FLG 21267458 2495503 Positive_regulation KRT73 TGM2 24278578 3180120 Positive_regulation KRT74 FLG 21267458 2495504 Positive_regulation KRT74 TGM2 24278578 3180122 Positive_regulation KRT75 FLG 21267458 2495497 Positive_regulation KRT75 TGM2 24278578 3180108 Positive_regulation KRT76 FLG 21267458 2495496 Positive_regulation KRT76 TGM2 24278578 3180106 Positive_regulation KRT77 FLG 21267458 2495494 Positive_regulation KRT77 TGM2 24278578 3180102 Positive_regulation KRT78 FLG 21267458 2495501 Positive_regulation KRT78 TGM2 24278578 3180116 Positive_regulation KRT79 FLG 21267458 2495505 Positive_regulation KRT79 TGM2 24278578 3180124 Positive_regulation KRT8 FLG 21267458 2495528 Positive_regulation KRT8 TGM2 24278578 3180170 Positive_regulation KRT8 WIF1 20573255 1856524 Positive_regulation KRT80 FLG 21267458 2495499 Positive_regulation KRT80 TGM2 24278578 3180112 Positive_regulation KRT81 FLG 21267458 2495537 Positive_regulation KRT81 TGM2 24278578 3180188 Positive_regulation KRT82 FLG 21267458 2495538 Positive_regulation KRT82 TGM2 24278578 3180190 Positive_regulation KRT83 FLG 21267458 2495539 Positive_regulation KRT83 TGM2 24278578 3180192 Positive_regulation KRT84 FLG 21267458 2495540 Positive_regulation KRT84 TGM2 24278578 3180194 Positive_regulation KRT85 FLG 21267458 2495541 Positive_regulation KRT85 TGM2 24278578 3180196 Positive_regulation KRT86 FLG 21267458 2495542 Positive_regulation KRT86 TGM2 24278578 3180198 Positive_regulation KRT9 FLG 21267458 2495529 Positive_regulation KRT9 TGM2 24278578 3180172 Positive_regulation KRTAP9-9 NES 9151683 1460067 Positive_regulation KRTAP9-9 NES 9151683 1460068 Positive_regulation KRTAP9-9 NES 9151683 1460089 Positive_regulation KRTAP9-9 NES 9151683 1460131 Positive_regulation KRTAP9-9 NES 9151683 1460304 Positive_regulation KSR1 EPHB2 23267331 960624 Positive_regulation KSR1 F2R 24829611 1650749 Positive_regulation KTN1 MAP2K6 21379332 2292190 Positive_regulation L1CAM EPHB2 19609353 2309902 Positive_regulation L1CAM EPHB2 22888955 734256 Positive_regulation LAG3 TNF 12110136 99163 Positive_regulation LAMA4 LAMA3 24971943 2985131 Positive_regulation LAMA5 PLAT 9531563 1466743 Positive_regulation LAMA5 PLAT 9531563 1466755 Positive_regulation LAMB1 EPHB2 22904067 2080402 Positive_regulation LAMB2 PLAT 9531563 1466745 Positive_regulation LAMB2 PLAT 9531563 1466757 Positive_regulation LAMB3 AKT1 22673183 471584 Positive_regulation LAMB3 AKT2 22673183 471585 Positive_regulation LAMB3 AKT3 22673183 471586 Positive_regulation LAMB3 CDC42 24352036 1632447 Positive_regulation LAMB3 EGF 16483354 3106683 Positive_regulation LAMB3 LGALS3 22073258 2569713 Positive_regulation LAMB3 LPA 9852164 1472520 Positive_regulation LAMB3 MYLIP 23159910 2181644 Positive_regulation LAMB3 MYLIP 23159910 2181646 Positive_regulation LAMB3 MYLIP 23320911 267329 Positive_regulation LAMB3 MYLIP 23483249 1141570 Positive_regulation LAMB3 MYLIP 23773282 483530 Positive_regulation LAMB3 MYLIP 24091622 441999 Positive_regulation LAMB3 RHO 8648297 1612683 Positive_regulation LAMB3 RHOA 9852164 1472523 Positive_regulation LAMB3 SKP1 24613287 94773 Positive_regulation LAMB3 SKP2 24613287 94774 Positive_regulation LAMB3 SMAD4 18664273 251259 Positive_regulation LAMB3 SMAD4 20307265 1853815 Positive_regulation LAMB3 SMAD4 20307265 1853821 Positive_regulation LAMB3 SNAI2 22531633 438665 Positive_regulation LAMB3 ZEB1 22531633 438666 Positive_regulation LAMB3 ZEB1 24212644 497878 Positive_regulation LAMC2 TNF 24990076 742214 Positive_regulation LAMC2 TNF 24990076 742254 Positive_regulation LAMC2 TNF 24990076 742256 Positive_regulation LAMC2 TNF 24990076 742260 Positive_regulation LAMC3 PLAT 9531563 1466747 Positive_regulation LAMC3 PLAT 9531563 1466759 Positive_regulation LAMP1 CTGF 22684333 541562 Positive_regulation LAMTOR3 MAP2K6 19930650 526230 Positive_regulation LAMTOR3 MAP2K6 19930650 526271 Positive_regulation LANCL1 EPHB2 22537317 355847 Positive_regulation LANCL1 TLR7 18584038 3074237 Positive_regulation LANCL1 TLR7 19430534 2416233 Positive_regulation LANCL1 TLR7 19430534 2416234 Positive_regulation LANCL1 TLR7 19430534 2416264 Positive_regulation LANCL1 TLR7 22427987 2610902 Positive_regulation LANCL1 TLR7 22570785 1688542 Positive_regulation LANCL1 TLR7 22661952 957556 Positive_regulation LANCL1 TLR7 23735002 2231743 Positive_regulation LANCL1 TNF 22506098 1680505 Positive_regulation LAP3 TLR7 25196483 3224173 Positive_regulation LAT EPHB2 12093866 1523719 Positive_regulation LAT EPHB2 14624253 2255209 Positive_regulation LAT PECAM1 20723025 1692075 Positive_regulation LATS1 FAS 22830020 1831466 Positive_regulation LBH EPHB2 24023871 2843841 Positive_regulation LBH EPHB2 24023871 2843842 Positive_regulation LBH EPHB2 24023871 2843855 Positive_regulation LBH EPHB2 24023871 2843856 Positive_regulation LBH IFI27 24093956 1869826 Positive_regulation LBP AMPH 23497014 343039 Positive_regulation LBP CAT 25045414 2229612 Positive_regulation LBP CSF3 23437199 2756174 Positive_regulation LBP CSF3 23437199 2756175 Positive_regulation LBP CSF3 23437199 2756176 Positive_regulation LBP CSF3 23437199 2756179 Positive_regulation LBP CSF3 23437199 2756180 Positive_regulation LBP CSF3 23437199 2756181 Positive_regulation LBP CSF3 23437199 2756182 Positive_regulation LBP CSF3 23437199 2756183 Positive_regulation LBP CSF3 23437199 2756186 Positive_regulation LBP CSF3 23437199 2756187 Positive_regulation LBP CSF3 23437199 2756188 Positive_regulation LBP CSF3 23437199 2756189 Positive_regulation LBP FPR2 21181483 810391 Positive_regulation LBP GABPA 25045414 2229619 Positive_regulation LBP GABPA 25045414 2229629 Positive_regulation LBP HMGB1 21660935 808364 Positive_regulation LBP HMOX1 24400114 2905763 Positive_regulation LBP HMOX1 25045414 2229613 Positive_regulation LBP IL10 25025695 2989375 Positive_regulation LBP IL11 25025695 2989376 Positive_regulation LBP IL13 25025695 2989377 Positive_regulation LBP IL15 25025695 2989378 Positive_regulation LBP IL16 25025695 2989379 Positive_regulation LBP IL18 25025695 2989380 Positive_regulation LBP IL19 25025695 2989381 Positive_regulation LBP IL1A 23125878 1641426 Positive_regulation LBP IL2 25025695 2989382 Positive_regulation LBP IL2 25552899 744114 Positive_regulation LBP IL20 25025695 2989383 Positive_regulation LBP IL21 25025695 2989384 Positive_regulation LBP IL22 18389070 631101 Positive_regulation LBP IL22 25025695 2989367 Positive_regulation LBP IL24 25025695 2989364 Positive_regulation LBP IL25 25025695 2989366 Positive_regulation LBP IL26 25025695 2989371 Positive_regulation LBP IL27 25025695 2989372 Positive_regulation LBP IL3 25025695 2989385 Positive_regulation LBP IL31 25025695 2989373 Positive_regulation LBP IL32 25025695 2989370 Positive_regulation LBP IL33 25025695 2989369 Positive_regulation LBP IL34 25025695 2989374 Positive_regulation LBP IL37 25025695 2989368 Positive_regulation LBP IL4 23517687 294305 Positive_regulation LBP IL4 25025695 2989386 Positive_regulation LBP IL5 25025695 2989387 Positive_regulation LBP IL6 23125878 1641427 Positive_regulation LBP IL6 23803652 1108024 Positive_regulation LBP IL6 25025695 2989388 Positive_regulation LBP IL7 25025695 2989389 Positive_regulation LBP IL8 25025695 2989390 Positive_regulation LBP IL9 25025695 2989391 Positive_regulation LBP LY96 23055710 1071990 Positive_regulation LBP LY96 24602493 295935 Positive_regulation LBP NFE2L2 25045414 2229605 Positive_regulation LBP NFE2L2 25045414 2229630 Positive_regulation LBP SOD2 25045414 2229611 Positive_regulation LBP TDGF1P3 1708813 1543158 Positive_regulation LBP TDGF1P3 1708813 1543163 Positive_regulation LBP TLR4 22442690 2612948 Positive_regulation LBP TLR4 23055710 1071989 Positive_regulation LBP TLR4 24602493 295934 Positive_regulation LBP TNF 25025695 2989365 Positive_regulation LCK EPHB2 14757743 1530887 Positive_regulation LCK EPHB2 21152094 2486260 Positive_regulation LCK EPHB2 21422171 1562973 Positive_regulation LCK EPHB2 23071622 2703400 Positive_regulation LCK EPHB2 23317458 534721 Positive_regulation LCK EPHB2 23317458 534723 Positive_regulation LCK EPHB2 23317458 534724 Positive_regulation LCK EPHB2 23317458 534730 Positive_regulation LCK EPHB2 23801991 907925 Positive_regulation LCK EPHB2 23874979 2823936 Positive_regulation LCN2 CAPN8 20200223 1774854 Positive_regulation LCN2 CAPN8 20200223 1774871 Positive_regulation LCN2 CAPN8 20200223 1774939 Positive_regulation LCN2 CAPN8 24497730 163725 Positive_regulation LCN2 IL1B 24742531 2188918 Positive_regulation LCN2 TLR7 21274449 632297 Positive_regulation LCN2 TNF 18475709 1745493 Positive_regulation LCN2 TNF 19390610 2308791 Positive_regulation LCN2 TNF 23238132 651896 Positive_regulation LCN2 TNF 24742531 2188917 Positive_regulation LCN2 TNF 25326017 1148460 Positive_regulation LCN2 TNF 25467539 3147771 Positive_regulation LCN2 TNF 25467539 3147777 Positive_regulation LDHD HBEGF 20946648 1859857 Positive_regulation LDLR EPHB2 19283084 3043426 Positive_regulation LDLR EPHB2 20953398 811820 Positive_regulation LDLR PCSK9 17328821 279517 Positive_regulation LDLR PCSK9 17328821 279518 Positive_regulation LDLR PCSK9 17328821 279519 Positive_regulation LDLR PCSK9 17328821 279521 Positive_regulation LDLR PCSK9 17328821 279522 Positive_regulation LDLR PCSK9 17328821 279524 Positive_regulation LDLR PCSK9 17328821 279525 Positive_regulation LDLR PCSK9 17328821 279526 Positive_regulation LDLR PCSK9 17940607 2379707 Positive_regulation LDLR PCSK9 17971861 2380085 Positive_regulation LDLR PCSK9 19196236 146452 Positive_regulation LDLR PCSK9 20423497 2112632 Positive_regulation LDLR PCSK9 20498851 2451194 Positive_regulation LDLR PCSK9 20498851 2451195 Positive_regulation LDLR PCSK9 20498851 2451197 Positive_regulation LDLR PCSK9 21352602 1723470 Positive_regulation LDLR PCSK9 21625524 2524702 Positive_regulation LDLR PCSK9 21773052 1638408 Positive_regulation LDLR PCSK9 21792295 742468 Positive_regulation LDLR PCSK9 22355267 1059724 Positive_regulation LDLR PCSK9 22764087 1637530 Positive_regulation LDLR PCSK9 22764087 1637531 Positive_regulation LDLR PCSK9 22764087 1637532 Positive_regulation LDLR PCSK9 22764087 1637533 Positive_regulation LDLR PCSK9 22764087 1637534 Positive_regulation LDLR PCSK9 22764087 1637535 Positive_regulation LDLR PCSK9 22764087 1637537 Positive_regulation LDLR PCSK9 22764087 1637539 Positive_regulation LDLR PCSK9 22848640 2669936 Positive_regulation LDLR PCSK9 23115612 668232 Positive_regulation LDLR PCSK9 23115612 668233 Positive_regulation LDLR PCSK9 23115612 668235 Positive_regulation LDLR PCSK9 23221464 1727542 Positive_regulation LDLR PCSK9 23430252 1206574 Positive_regulation LDLR PCSK9 23430252 1206575 Positive_regulation LDLR PCSK9 23430252 1206593 Positive_regulation LDLR PCSK9 23430252 1206594 Positive_regulation LDLR PCSK9 23430252 1206595 Positive_regulation LDLR PCSK9 23675525 2793507 Positive_regulation LDLR PCSK9 23675525 2793508 Positive_regulation LDLR PCSK9 23675525 2793509 Positive_regulation LDLR PCSK9 23675525 2793524 Positive_regulation LDLR PCSK9 23951290 2834117 Positive_regulation LDLR PCSK9 23951290 2834118 Positive_regulation LDLR PCSK9 23951290 2834119 Positive_regulation LDLR PCSK9 23951290 2834120 Positive_regulation LDLR PCSK9 24115837 742807 Positive_regulation LDLR PCSK9 24115837 742808 Positive_regulation LDLR PCSK9 24115837 742809 Positive_regulation LDLR PCSK9 24115837 742824 Positive_regulation LDLR PCSK9 24252756 179020 Positive_regulation LDLR PCSK9 24278757 3150674 Positive_regulation LDLR PCSK9 24278757 3150678 Positive_regulation LDLR PCSK9 24278757 3150690 Positive_regulation LDLR PCSK9 24278757 3150691 Positive_regulation LDLR PCSK9 24296664 1637906 Positive_regulation LDLR PCSK9 24296664 1637909 Positive_regulation LDLR PCSK9 24460800 510718 Positive_regulation LDLR PCSK9 24533584 1726725 Positive_regulation LDLR PCSK9 24901470 2976870 Positive_regulation LDLR PCSK9 24921629 2300861 Positive_regulation LDLR PCSK9 25003069 731085 Positive_regulation LDLR PCSK9 25042549 19266 Positive_regulation LDLR PCSK9 25042549 19283 Positive_regulation LDLR PCSK9 25064003 1726993 Positive_regulation LDLR PCSK9 25172365 785277 Positive_regulation LDLR PCSK9 25426564 658126 Positive_regulation LDLR PCSK9 PMC2794151 2106903 Positive_regulation LDLR PLAT 18813339 2396826 Positive_regulation LDLR TNF 23484158 179770 Positive_regulation LDLR TNF 25276058 1762686 Positive_regulation LEF1 CCND1 24651473 2936585 Positive_regulation LEF1 OSR1 24931004 1681298 Positive_regulation LEF1 TNF 24479486 1667596 Positive_regulation LEF1 WNT7A 25170755 3003851 Positive_regulation LEMD1 PSMB9 22612225 150528 Positive_regulation LEO1 ALOX5 8666909 1597099 Positive_regulation LEO1 F2R PMC2756345 496006 Positive_regulation LEO1 GPR115 21079759 3049843 Positive_regulation LEO1 GPR115 25375862 3023766 Positive_regulation LEO1 GPR132 21079759 3049832 Positive_regulation LEO1 GPR132 25375862 3023755 Positive_regulation LEO1 GPR87 21079759 3049912 Positive_regulation LEO1 GPR87 25375862 3023835 Positive_regulation LEO1 LPCAT1 21079759 3049448 Positive_regulation LEO1 LPCAT1 25415055 177552 Positive_regulation LEO1 TNF 18475680 1745379 Positive_regulation LEO1 TNF 18475682 1745392 Positive_regulation LEO1 TNF 18475742 1746301 Positive_regulation LEO1 TNF 21082032 2482401 Positive_regulation LEO1 TNF 2137857 1562739 Positive_regulation LEO1 TNF 2137857 1562753 Positive_regulation LEO1 TNF 21860543 1749392 Positive_regulation LEO1 TNF 2659725 1577678 Positive_regulation LEO1 TNF 3049910 1579749 Positive_regulation LEO1 TNF 3049910 1579750 Positive_regulation LEO1 TNF 3049910 1579751 Positive_regulation LEO1 TNF 3049910 1579752 Positive_regulation LEO1 TNF 3049910 1579782 Positive_regulation LEO1 TNF 3049910 1579790 Positive_regulation LEO1 TNF 3049910 1579800 Positive_regulation LEO1 TNF 3049910 1579805 Positive_regulation LEO1 TNF 3119758 1580143 Positive_regulation LEO1 TNF 3119758 1580144 Positive_regulation LEO1 TNF 3119758 1580145 Positive_regulation LEO1 TNF 3119758 1580146 Positive_regulation LEO1 TNF 3119758 1580147 Positive_regulation LEO1 TNF 3119758 1580172 Positive_regulation LEO1 TNF 7516414 1589278 Positive_regulation LEO1 TNF 7516414 1589283 Positive_regulation LEO1 TNF 7516414 1589303 Positive_regulation LEO1 TNF 7516414 1589308 Positive_regulation LEP CCND1 17274833 460659 Positive_regulation LEP CCND1 23300886 2737048 Positive_regulation LEP EPHB2 19066310 707370 Positive_regulation LEP EPHB2 19066310 707371 Positive_regulation LEP EPHB2 19066310 707372 Positive_regulation LEP EPHB2 19066310 707387 Positive_regulation LEP EPHB2 19066310 707388 Positive_regulation LEP EPHB2 19066310 707405 Positive_regulation LEP EPHB2 19066310 707424 Positive_regulation LEP EPHB2 23028384 3075924 Positive_regulation LEP EPHB2 23028384 3075954 Positive_regulation LEP EPHB2 23216800 2113657 Positive_regulation LEP EPHB2 23216800 2113658 Positive_regulation LEP EPHB2 25352831 881316 Positive_regulation LEP EPHB2 25352831 881320 Positive_regulation LEP EPHB2 25403445 3147030 Positive_regulation LEP EPHB2 25403445 3147047 Positive_regulation LEP EPHB2 25506547 1888884 Positive_regulation LEP FOXO1 24675731 2946778 Positive_regulation LEP HRH1 20642857 402706 Positive_regulation LEP MAP2K6 23056265 2700820 Positive_regulation LEP MMP28 21826146 1144695 Positive_regulation LEP MMP7 21826146 1144710 Positive_regulation LEP MUC16 24714276 88521 Positive_regulation LEP PGC 20532036 2452168 Positive_regulation LEP PGC 25514415 1135749 Positive_regulation LEP TNF 17472433 2369016 Positive_regulation LEP TNF 17540037 312988 Positive_regulation LEP TNF 20414465 1747456 Positive_regulation LEP TNF 20607056 1681553 Positive_regulation LEP TNF 21243519 1491587 Positive_regulation LEP TNF 21655142 1075793 Positive_regulation LEP TNF 21960997 980056 Positive_regulation LEP TNF 22048440 3126125 Positive_regulation LEP TNF 22096344 1628222 Positive_regulation LEP TNF 22312273 1094878 Positive_regulation LEP TNF 22313574 1724435 Positive_regulation LEP TNF 22518191 1143861 Positive_regulation LEP TNF 22911724 2675989 Positive_regulation LEP TNF 22911724 2675990 Positive_regulation LEP TNF 23343052 1036502 Positive_regulation LEP TNF 23565493 1044582 Positive_regulation LEP TNF 24132155 1113516 Positive_regulation LEP TNF 24202338 497515 Positive_regulation LEP TNF 24455420 1152551 Positive_regulation LEP TNF 24676492 453655 Positive_regulation LEP TNF 24683394 3070932 Positive_regulation LEP TNF 24757680 189545 Positive_regulation LEP TNF 24786095 1126316 Positive_regulation LEP TNF 25047119 2990885 Positive_regulation LEP TNF 8996253 1599927 Positive_regulation LEP TUB 22966070 724651 Positive_regulation LEP TUB 22966070 724652 Positive_regulation LEPR CCND1 17274833 460660 Positive_regulation LEPR GLP1R 22249232 1140325 Positive_regulation LGALS1 EPHB2 20700538 2458214 Positive_regulation LGALS1 LGALS7B 23530091 2182876 Positive_regulation LGALS1 SUSD2 25351403 3146320 Positive_regulation LGALS1 TNF 12966436 423288 Positive_regulation LGALS3 IFI27 24971481 548972 Positive_regulation LGALS3 IFI27 24971481 548973 Positive_regulation LGALS4 LGALS7B 21624158 1234856 Positive_regulation LGALS7B AKTIP 23530091 2182815 Positive_regulation LGALS7B AKTIP 23530091 2182874 Positive_regulation LGALS7B AKTIP 23530091 2182901 Positive_regulation LGALS7B AKTIP 23530091 2182902 Positive_regulation LGALS7B AKTIP 23530091 2182906 Positive_regulation LGALS7B BCL2 21289092 1786158 Positive_regulation LGALS7B BCL2 21289092 1786167 Positive_regulation LGALS7B CEBPA 24789216 2960207 Positive_regulation LGALS7B DBP 24260025 2284346 Positive_regulation LGALS7B GAL 21624158 1234848 Positive_regulation LGALS7B GC 24260025 2284351 Positive_regulation LGALS7B HRAS 23530091 2182833 Positive_regulation LGALS7B HRAS 23530091 2182834 Positive_regulation LGALS7B KRAS 23530091 2182835 Positive_regulation LGALS7B LGALS1 23530091 2182875 Positive_regulation LGALS7B LGALS3 21624158 1234849 Positive_regulation LGALS7B LGALS4 21131977 1975786 Positive_regulation LGALS7B LGALS4 21624158 1234850 Positive_regulation LGALS7B LGALS4 21624158 1234851 Positive_regulation LGALS7B MMP9 24515895 492440 Positive_regulation LGALS7B NRAS 23530091 2182836 Positive_regulation LGALS7B PSMD4 25264624 3010733 Positive_regulation LGALS7B RPGR 21289092 1786169 Positive_regulation LGALS7B TCF12 24515895 492429 Positive_regulation LGALS7B TCF15 24515895 492430 Positive_regulation LGALS7B TCF19 24515895 492431 Positive_regulation LGALS7B TCF20 24515895 492432 Positive_regulation LGALS7B TCF21 24515895 492433 Positive_regulation LGALS7B TCF23 24515895 492437 Positive_regulation LGALS7B TCF24 24515895 492439 Positive_regulation LGALS7B TCF25 24515895 492438 Positive_regulation LGALS7B TCF3 24515895 492434 Positive_regulation LGALS7B TCF4 24515895 492435 Positive_regulation LGALS7B TCF7 24515895 492436 Positive_regulation LGALS7B TP53 19698150 3083645 Positive_regulation LGALS7B TP53 23530091 2182813 Positive_regulation LGALS7B TP53 23530091 2182814 Positive_regulation LGALS7B TP53 23530091 2182832 Positive_regulation LGALS7B TP53 23530091 2182873 Positive_regulation LGALS7B TP53 23967302 2835652 Positive_regulation LGALS7B TP53 23967302 2835653 Positive_regulation LGALS7B TP53 23967302 2835654 Positive_regulation LGALS7B TP53 23967302 2835655 Positive_regulation LGALS7B TP53 23967302 2835656 Positive_regulation LGALS7B TP53 23967302 2835657 Positive_regulation LGALS7B TP53 23967302 2835659 Positive_regulation LGALS7B TP53 23967302 2835661 Positive_regulation LGALS7B TP53 23967302 2835662 Positive_regulation LGALS7B TP53 23967302 2835663 Positive_regulation LGALS7B TP53 23967302 2835664 Positive_regulation LGALS7B TP53 23967302 2835667 Positive_regulation LGALS7B TP53 23967302 2835668 Positive_regulation LGALS7B TP53 25277199 2203317 Positive_regulation LGALS7B TP53 25277199 2203321 Positive_regulation LGALS7B TP53 25277199 2203324 Positive_regulation LGALS9 IL1B 16749930 242023 Positive_regulation LGALS9 TLR7 23967307 2836134 Positive_regulation LGI1 NES 24633211 2934720 Positive_regulation LGI2 NES 24633211 2934717 Positive_regulation LGI3 NES 24633211 2934718 Positive_regulation LGI4 NES 24633211 2934719 Positive_regulation LGMN CST6 20074384 255203 Positive_regulation LGR4 IL1B 24066001 1028796 Positive_regulation LGR5 IL1B 24066001 1028800 Positive_regulation LGR6 IL1B 24066001 1028798 Positive_regulation LHCGR EPHB2 24375413 1208772 Positive_regulation LHX2 PLAU 23864708 1816977 Positive_regulation LHX2 PLAU 23864708 1816986 Positive_regulation LHX2 PLAU 23864708 1816987 Positive_regulation LHX2 PLAU 23864708 1816991 Positive_regulation LHX2 PLAU 23864708 1816996 Positive_regulation LHX2 PLAU 23864708 1817024 Positive_regulation LHX4 GABPA 23766854 2226183 Positive_regulation LHX4 ISL1 25120431 869988 Positive_regulation LIF EDN2 19693290 1909470 Positive_regulation LIF EDN2 20454693 1910714 Positive_regulation LIF EDN2 23372671 2745722 Positive_regulation LIF EPHB2 16271139 248971 Positive_regulation LIF EPHB2 22143885 1566348 Positive_regulation LIF EPHB2 24710148 986014 Positive_regulation LIF EPHB2 25119572 2997124 Positive_regulation LIF EPHB2 25340554 3018712 Positive_regulation LIF IL1B 25436109 1161820 Positive_regulation LIF MAP2K6 21798094 3160304 Positive_regulation LIF MAP2K6 22143885 1566356 Positive_regulation LIF MAP2K6 25604210 3149706 Positive_regulation LIF STK39 9298977 1463121 Positive_regulation LIF TNF 21637744 2525867 Positive_regulation LIF TNF 21637744 2525927 Positive_regulation LIF TNF 23236394 2726147 Positive_regulation LIF TNF 23236394 2726148 Positive_regulation LIF TNF 23236394 2726170 Positive_regulation LIF TNF 23236394 2726171 Positive_regulation LIF TNF 23236394 2726176 Positive_regulation LIF TNF 23236394 2726177 Positive_regulation LIF TNF 24008729 565098 Positive_regulation LIF TNF 24008729 565099 Positive_regulation LIF TNF 24008729 565100 Positive_regulation LIF TNF 24008729 565101 Positive_regulation LIF TNF 24008729 565102 Positive_regulation LIF TNF 24008729 565103 Positive_regulation LIF TNF 24008729 565104 Positive_regulation LIF TNF 24008729 565421 Positive_regulation LIF TNF 24008729 565422 Positive_regulation LIF TNF 24008729 565423 Positive_regulation LIF TNF 24244348 2879476 Positive_regulation LIF TNF PMC3273219 99573 Positive_regulation LIG4 FHL1 21785140 2065635 Positive_regulation LILRA4 TLR7 24586760 2926310 Positive_regulation LILRA4 TLR7 24586760 2926311 Positive_regulation LILRB1 EPHB2 24349829 478299 Positive_regulation LILRB2 TLR7 19860908 353158 Positive_regulation LILRB4 TLR7 19860908 353168 Positive_regulation LIMS1 NES 21390327 2506438 Positive_regulation LIN37 AXIN2 21814488 2276966 Positive_regulation LIN37 TNF 25368492 1636244 Positive_regulation LIN52 AXIN2 21814488 2276958 Positive_regulation LIN52 TNF 25368492 1636241 Positive_regulation LIN54 AXIN2 21814488 2276960 Positive_regulation LIN54 TNF 25368492 1636242 Positive_regulation LIN9 AXIN2 21814488 2276964 Positive_regulation LIN9 TNF 25368492 1636243 Positive_regulation LINC00284 E2F4 21436991 1219452 Positive_regulation LINC00284 LMNA 22574215 2633206 Positive_regulation LINC00284 LMNB1 24895011 215017 Positive_regulation LINC00284 LMNB2 24895011 215018 Positive_regulation LINC00284 RBL2 21436991 1219453 Positive_regulation LINC00284 SUN1 24667841 2942001 Positive_regulation LINC00284 SUN2 24667841 2941999 Positive_regulation LINC00284 SUN3 24667841 2942002 Positive_regulation LINC00284 SUN5 24667841 2942000 Positive_regulation LINC00341 E2F4 21436991 1219372 Positive_regulation LINC00341 LMNA 22574215 2633166 Positive_regulation LINC00341 LMNB1 24895011 214937 Positive_regulation LINC00341 LMNB2 24895011 214938 Positive_regulation LINC00341 RBL2 21436991 1219373 Positive_regulation LINC00341 SUN1 24667841 2941841 Positive_regulation LINC00341 SUN2 24667841 2941839 Positive_regulation LINC00341 SUN3 24667841 2941842 Positive_regulation LINC00341 SUN5 24667841 2941840 Positive_regulation LIPA FOXO1 24136225 568089 Positive_regulation LIPA FOXO1 24136225 568090 Positive_regulation LIPA FOXO1 24136225 568092 Positive_regulation LIPE PGC 21904680 154550 Positive_regulation LIPE TNF 16106106 1740059 Positive_regulation LIPE TNF 24475180 2915166 Positive_regulation LIPG ACVR2B 20856813 2474788 Positive_regulation LIPG CETP 22431312 778567 Positive_regulation LIPG CPA1 25353002 1888746 Positive_regulation LIPG INS 18523577 2389979 Positive_regulation LIPG INS 19073774 707515 Positive_regulation LIPG INS 19136654 707791 Positive_regulation LIPG INS 20661274 2456485 Positive_regulation LIPG INS 20661274 2456487 Positive_regulation LIPG INS 23423567 726358 Positive_regulation LIPG INS 23620811 2783516 Positive_regulation LIPG INS 23671593 2792220 Positive_regulation LIPG INS 23671593 2792221 Positive_regulation LIPG TNF 16177180 2017695 Positive_regulation LIPG TNF 16177180 2017704 Positive_regulation LMNA PRODH 24039956 2845126 Positive_regulation LMNB1 MAP2K6 22496421 1801948 Positive_regulation LMX1A FOXA1 25249938 871288 Positive_regulation LMX1A MSX1 18826576 1832830 Positive_regulation LMX1B FOXA1 25249938 871290 Positive_regulation LOR EPHB2 17449939 1634812 Positive_regulation LOX CTGF 22363622 2601303 Positive_regulation LOX TNF 24971753 2985056 Positive_regulation LPA ANGPT1 19297368 513370 Positive_regulation LPA CTGF 19152120 1478410 Positive_regulation LPA CTGF 23259815 856348 Positive_regulation LPA EPHB2 18762583 1357061 Positive_regulation LPA EPHB2 19077254 385114 Positive_regulation LPA EPHB2 19742132 1088768 Positive_regulation LPA EPHB2 21209852 2491379 Positive_regulation LPA EPHB2 21209852 2491380 Positive_regulation LPA EPHB2 21209852 2491409 Positive_regulation LPA EPHB2 21209852 2491468 Positive_regulation LPA EPHB2 21406114 286547 Positive_regulation LPA EPHB2 21686182 1091068 Positive_regulation LPA EPHB2 22493518 1568033 Positive_regulation LPA EPHB2 23706742 517251 Positive_regulation LPA EPHB2 24928086 273902 Positive_regulation LPA MMP28 21151531 1081370 Positive_regulation LPA MMP28 25356505 1133160 Positive_regulation LPA MMP7 21151531 1081386 Positive_regulation LPA MMP7 25356505 1133193 Positive_regulation LPA PCSK9 21232153 1723404 Positive_regulation LPA PCSK9 23329883 1084342 Positive_regulation LPA PCSK9 25600226 143168 Positive_regulation LPA TNF 20356387 1853838 Positive_regulation LPA TNF 20356387 1853841 Positive_regulation LPA TNF 21765444 13139 Positive_regulation LPA TNF 21765444 13145 Positive_regulation LPA TNF 23499576 3204120 Positive_regulation LPAR1 MMP28 25356505 1132846 Positive_regulation LPAR1 MMP28 25356505 1132847 Positive_regulation LPAR1 MMP7 25356505 1132895 Positive_regulation LPAR1 MMP7 25356505 1132896 Positive_regulation LPAR1 TNF 25356505 1132837 Positive_regulation LPAR2 EPHB2 21406114 286493 Positive_regulation LPAR2 EPHB2 21406114 286494 Positive_regulation LPAR2 EPHB2 21406114 286568 Positive_regulation LPAR2 EPHB2 21686182 1091052 Positive_regulation LPAR3 EPHB2 21686182 1091042 Positive_regulation LPCAT1 CA2 22676268 229982 Positive_regulation LPCAT1 CA2 22676268 229985 Positive_regulation LPCAT1 CA2 22676268 229987 Positive_regulation LPCAT1 CA2 22676268 229992 Positive_regulation LPCAT2 LPCAT1 22296727 1899026 Positive_regulation LPCAT2 LPCAT1 24742674 1209403 Positive_regulation LPCAT3 TNF 17965763 810771 Positive_regulation LPCAT3 TNF 22183712 1146755 Positive_regulation LPIN1 PGC 17612398 300676 Positive_regulation LPIN1 PGC 19753306 2426497 Positive_regulation LPIN1 PGC 21857965 2544432 Positive_regulation LPIN1 PGC 21857965 2544438 Positive_regulation LPIN1 PGC 21857965 2544443 Positive_regulation LPIN1 PGC 23236470 2726517 Positive_regulation LPL FOXO1 17531095 2013466 Positive_regulation LPL FOXO1 23443131 1102639 Positive_regulation LPL FOXO1 24520982 2113987 Positive_regulation LPL GLP1R 24843404 1492981 Positive_regulation LPL GLP1R 24843641 1494203 Positive_regulation LPL MMP28 15670333 278047 Positive_regulation LPL MMP7 15670333 278062 Positive_regulation LPL TNF 20670429 1723190 Positive_regulation LPL TNF 22682420 126131 Positive_regulation LPL TNF 24966707 1235315 Positive_regulation LPL TNF 7577459 444039 Positive_regulation LRG1 TNF 25246736 1636205 Positive_regulation LRP1 CTGF 19214781 1478531 Positive_regulation LRP1 CTGF 25514242 1135695 Positive_regulation LRP1 CTGF 25514242 1135696 Positive_regulation LRP1 EPHB2 16908670 1331941 Positive_regulation LRP1 EPHB2 16908670 1331942 Positive_regulation LRP1 EPHB2 16908670 1331943 Positive_regulation LRP1 EPHB2 16908670 1331951 Positive_regulation LRP1 FZD4 22645520 874199 Positive_regulation LRP1 PCSK9 22848640 2669928 Positive_regulation LRP1 PCSK9 23675525 2793511 Positive_regulation LRP1 PCSK9 23675525 2793512 Positive_regulation LRP1 PCSK9 23675525 2793513 Positive_regulation LRP1 PCSK9 23675525 2793517 Positive_regulation LRP1 PCSK9 23675525 2793518 Positive_regulation LRP1 PCSK9 23675525 2793519 Positive_regulation LRP1 PCSK9 23675525 2793520 Positive_regulation LRP1 PCSK9 23675525 2793525 Positive_regulation LRP1 PCSK9 23675525 2793527 Positive_regulation LRP1 PCSK9 25340851 3018946 Positive_regulation LRP1 PLAT 23866919 1895816 Positive_regulation LRP10 CTGF 19214781 1478526 Positive_regulation LRP10 FZD4 22645520 873835 Positive_regulation LRP11 CTGF 19214781 1478527 Positive_regulation LRP11 FZD4 22645520 873878 Positive_regulation LRP12 CTGF 19214781 1478529 Positive_regulation LRP12 FZD4 22645520 873979 Positive_regulation LRP2 CLU 25158045 986437 Positive_regulation LRP2 CTGF 19214781 1478532 Positive_regulation LRP2 FZD4 22645520 874219 Positive_regulation LRP3 CTGF 19214781 1478533 Positive_regulation LRP3 FZD4 22645520 874239 Positive_regulation LRP4 CTGF 19214781 1478534 Positive_regulation LRP4 FZD4 22645520 874259 Positive_regulation LRP5 AXIN2 22022411 2563024 Positive_regulation LRP5 AXIN2 23778311 1721638 Positive_regulation LRP5 AXIN2 24931005 2192380 Positive_regulation LRP5 CTGF 19214781 1478535 Positive_regulation LRP5 FZD4 22645520 874279 Positive_regulation LRP5 WNT7A 24479426 131589 Positive_regulation LRP6 AXIN2 22357953 1486780 Positive_regulation LRP6 AXIN2 24474204 3081486 Positive_regulation LRP6 CTGF 19214781 1478536 Positive_regulation LRP6 CTGF 24455745 186426 Positive_regulation LRP6 EPHB2 22558232 2624706 Positive_regulation LRP6 EPHB2 22558232 2624781 Positive_regulation LRP6 EPHB2 22558232 2624791 Positive_regulation LRP6 FZD4 22372892 238413 Positive_regulation LRP6 FZD4 22645520 874299 Positive_regulation LRP6 OSR1 24931004 1681299 Positive_regulation LRP8 CTGF 19214781 1478537 Positive_regulation LRP8 FZD4 22645520 874319 Positive_regulation LRRC31 RLN1 15707501 308802 Positive_regulation LRRC31 RLN2 15707501 308803 Positive_regulation LRRC31 RLN3 15707501 308804 Positive_regulation LRRC55 RLN1 15707501 308859 Positive_regulation LRRC55 RLN2 15707501 308860 Positive_regulation LRRC55 RLN3 15707501 308861 Positive_regulation LRRC7 F2R 21941675 1082240 Positive_regulation LRRK2 CD14 21738687 2533266 Positive_regulation LRRK2 RGS2 25071441 932190 Positive_regulation LRRK2 TLR7 22723946 2655273 Positive_regulation LRRK2 TLR7 25071441 932182 Positive_regulation LRRK2 TNS1 25206509 2004917 Positive_regulation LRRK2 TNS1 25206509 2004929 Positive_regulation LRRN2 HOXB1 19602272 1994773 Positive_regulation LRRN2 HOXB1 19602272 1994774 Positive_regulation LRRN2 HOXB1 19602272 1994775 Positive_regulation LRRN2 HOXB1 19602272 1994783 Positive_regulation LRRN2 HOXB1 19602272 1994787 Positive_regulation LRRN2 HOXB1 19602272 1994799 Positive_regulation LRRN2 HOXB1 19602272 1994800 Positive_regulation LRRN2 SHH 19602272 1994771 Positive_regulation LRRN2 SHH 19602272 1994772 Positive_regulation LRRN2 SHH 19602272 1994782 Positive_regulation LRRN2 SHH 19602272 1994797 Positive_regulation LRRN2 SHH 19602272 1994798 Positive_regulation LSS ETV7 24357328 740821 Positive_regulation LSS ETV7 24357328 740823 Positive_regulation LST1 TNF 25400582 966610 Positive_regulation LTA ALOX5 23194405 388259 Positive_regulation LTA CD14 19847289 2429159 Positive_regulation LTA EPHB2 24971655 2984750 Positive_regulation LTA TNF 22183712 1146757 Positive_regulation LTA TNF 23031213 3113152 Positive_regulation LTA TNF 24069456 2853352 Positive_regulation LTA TNF 25057505 1622529 Positive_regulation LTA TNF 3279996 443322 Positive_regulation LTA TNF 3435705 443394 Positive_regulation LTA TNF 3888244 443555 Positive_regulation LTB ALOX5 15998790 1536603 Positive_regulation LTB ALOX5 19503090 1948727 Positive_regulation LTB ALOX5 21896202 358367 Positive_regulation LTB ALOX5 23991239 2372085 Positive_regulation LTB ALOX5 24465039 694689 Positive_regulation LTB ALOX5 24889202 1576559 Positive_regulation LTB ALOX5 25045574 1083000 Positive_regulation LTB ALOX5 25045574 1083001 Positive_regulation LTB ALOX5 25045574 1083003 Positive_regulation LTB ARSA 23638194 2371858 Positive_regulation LTB EPHB2 23799854 440997 Positive_regulation LTB IL1B 9836494 1764023 Positive_regulation LTB LBP 7513013 1589125 Positive_regulation LTB MAP2K6 24634497 1624476 Positive_regulation LTB TLR7 24634497 1624533 Positive_regulation LTB TNF 1460427 1529614 Positive_regulation LTB TNF 18472956 1743393 Positive_regulation LTB TNF 18472956 1743401 Positive_regulation LTB TNF 2659725 1577679 Positive_regulation LTB4R2 EPHB2 23799854 440994 Positive_regulation LTF EPHB2 15932641 382978 Positive_regulation LTF EPHB2 22675451 2648436 Positive_regulation LTF EPHB2 23346360 3133971 Positive_regulation LTF MAP2K6 16966424 1333171 Positive_regulation LTF PPBP 18519646 1551407 Positive_regulation LTF TF 24376607 2901404 Positive_regulation LY75 FAS 24677194 1029713 Positive_regulation LY75 TNF 15743491 102699 Positive_regulation LY86 FAS 24677194 1029700 Positive_regulation LY86 TNF 15743491 102691 Positive_regulation LY9 FAS 24677194 1029716 Positive_regulation LY9 TNF 15743491 102701 Positive_regulation LY96 CD14 14517279 1529120 Positive_regulation LY96 CD14 14517279 1529127 Positive_regulation LY96 CD14 20388715 1187034 Positive_regulation LY96 CD14 20419140 2447170 Positive_regulation LY96 CD14 20419140 2447174 Positive_regulation LY96 CD14 20978830 1050610 Positive_regulation LY96 CD14 23055710 1071986 Positive_regulation LY96 CD14 24244872 2233904 Positive_regulation LY96 CD14 24602493 295932 Positive_regulation LY96 CD14 24971030 1140230 Positive_regulation LY96 CD14 25332099 607553 Positive_regulation LY96 CD14 25360682 3021148 Positive_regulation LY96 FAS 24677194 1029703 Positive_regulation LY96 LBP 23055710 1071987 Positive_regulation LY96 LBP 24602493 295933 Positive_regulation LY96 LBP 25184525 3004852 Positive_regulation LY96 TNF 15743491 102693 Positive_regulation LY96 TNF 24064574 2118060 Positive_regulation LYN MIP 20380698 3118837 Positive_regulation LYN MIP 20380698 3118844 Positive_regulation LYRM1 TNF 22110480 832221 Positive_regulation LYZ IL1B 22724024 2655606 Positive_regulation LYZ IL1B 22724024 2655609 Positive_regulation LYZ TNF 18475501 1744091 Positive_regulation LYZ TNF 18475501 1744096 Positive_regulation LYZ TNF 22724024 2655608 Positive_regulation MAA TNF 15826301 224729 Positive_regulation MADCAM1 TNF 11481030 312663 Positive_regulation MADCAM1 TNF 11481030 312664 Positive_regulation MADCAM1 TNF 11481030 312665 Positive_regulation MADCAM1 TNF 11481030 312686 Positive_regulation MADCAM1 TNF 12003644 312735 Positive_regulation MADCAM1 TNF 12003644 312736 Positive_regulation MADCAM1 TNF 12003644 312739 Positive_regulation MADCAM1 TNF 12625840 312751 Positive_regulation MADCAM1 TNF 12625840 312752 Positive_regulation MADCAM1 TNF 15694007 391922 Positive_regulation MADCAM1 TNF 15694007 391923 Positive_regulation MADCAM1 TNF 15694007 391950 Positive_regulation MADCAM1 TNF 16259632 1624799 Positive_regulation MADCAM1 TNF 16259632 1624800 Positive_regulation MADCAM1 TNF 17868448 392099 Positive_regulation MADCAM1 TNF 17868448 392100 Positive_regulation MADCAM1 TNF 17868448 392101 Positive_regulation MADCAM1 TNF 17868448 392102 Positive_regulation MADCAM1 TNF 17868448 392109 Positive_regulation MADCAM1 TNF 17868448 392110 Positive_regulation MADCAM1 TNF 17868448 392111 Positive_regulation MADCAM1 TNF 17868448 392114 Positive_regulation MADCAM1 TNF 17868448 392115 Positive_regulation MADCAM1 TNF 21373262 1490003 Positive_regulation MADCAM1 TNF 21373262 1490004 Positive_regulation MADCAM1 TNF 24562309 1959947 Positive_regulation MADCAM1 TNF 24646507 652069 Positive_regulation MADD RAB31 19653898 1833768 Positive_regulation MAF MIP 17262012 1906280 Positive_regulation MAFA EPHB2 19502418 708722 Positive_regulation MAGEE1 EDN2 23533305 1751779 Positive_regulation MAGI1 TNF 12061424 1738143 Positive_regulation MAK MAP2K6 25188365 2362673 Positive_regulation MAL TLR7 20652007 1747491 Positive_regulation MAL TLR7 24624130 911867 Positive_regulation MALT1 AGR2 21396111 527128 Positive_regulation MALT1 EPHB2 19305426 2124961 Positive_regulation MALT1 TNFSF10 22719861 2653290 Positive_regulation MALT1 TNS1 25009550 970907 Positive_regulation MAML1 LINC00284 24013378 1111261 Positive_regulation MAML1 LINC00341 24013378 1111221 Positive_regulation MAML3 HES1 21716644 936386 Positive_regulation MAML3 HES5 21716644 936385 Positive_regulation MAML3 NOTCH1 23284900 2731172 Positive_regulation MAML3 NOTCH2 23284900 2731173 Positive_regulation MAML3 NOTCH3 23284900 2731174 Positive_regulation MAML3 NOTCH4 23284900 2731175 Positive_regulation MAMLD1 KTN1 22719628 3164 Positive_regulation MAMLD1 SNCA 20624440 2008411 Positive_regulation MAMLD1 TMEM245 22719628 3163 Positive_regulation MAOA ARNTL 25395965 3085969 Positive_regulation MAOA BCHE 22110357 841472 Positive_regulation MAOA CA2 17868476 384297 Positive_regulation MAOA CA2 17868476 384298 Positive_regulation MAOA CA2 24292328 3138914 Positive_regulation MAOA CLOCK 25395965 3085966 Positive_regulation MAOA FOXO1 21267416 2495410 Positive_regulation MAOA IL6 22906985 1718403 Positive_regulation MAOA IL6 22906985 1718404 Positive_regulation MAOA IL6 22906985 1718412 Positive_regulation MAOA IL6 22906985 1718415 Positive_regulation MAOA MYLIP 24244526 2880376 Positive_regulation MAOA SIRT1 24244526 2880380 Positive_regulation MAOA SRY 21695109 2276413 Positive_regulation MAOA TCF12 25395965 3085957 Positive_regulation MAOA TCF15 25395965 3085958 Positive_regulation MAOA TCF19 25395965 3085959 Positive_regulation MAOA TCF20 25395965 3085960 Positive_regulation MAOA TCF21 25395965 3085961 Positive_regulation MAOA TCF23 25395965 3085965 Positive_regulation MAOA TCF24 25395965 3085968 Positive_regulation MAOA TCF25 25395965 3085967 Positive_regulation MAOA TCF3 25395965 3085962 Positive_regulation MAOA TCF4 25395965 3085963 Positive_regulation MAOA TCF7 25395965 3085964 Positive_regulation MAOA TMBIM6 24292328 3138909 Positive_regulation MAOA TMBIM6 24292328 3138918 Positive_regulation MAOB PGC 22246294 1033618 Positive_regulation MAP1LC3A CLU 25503391 1947694 Positive_regulation MAP1LC3A CLU 25503391 1947695 Positive_regulation MAP1LC3A CLU 25503391 1947708 Positive_regulation MAP1LC3A CTGF 22684333 541563 Positive_regulation MAP1LC3A EPHB2 19448671 2125311 Positive_regulation MAP1LC3A EPHB2 20368806 2444975 Positive_regulation MAP1LC3A EPHB2 24212825 498942 Positive_regulation MAP1LC3A FOXO1 21798082 3160152 Positive_regulation MAP1LC3A RAB31 23892275 18166 Positive_regulation MAP1LC3A RAB31 23892275 18372 Positive_regulation MAP1LC3A TLR7 24818040 3151670 Positive_regulation MAP1LC3A TNF 22257771 3160817 Positive_regulation MAP1LC3A TNF 23936437 2830438 Positive_regulation MAP1LC3A TNF 24751948 2956194 Positive_regulation MAP1LC3A TNF 24751948 2956196 Positive_regulation MAP2 EPHB2 17984326 1346307 Positive_regulation MAP2 EPHB2 17984326 1346320 Positive_regulation MAP2 F2R 24705212 985505 Positive_regulation MAP2 WNT7A 25170755 3003883 Positive_regulation MAP2K1 CCND1 22833568 1806096 Positive_regulation MAP2K1 CD14 20150966 1213528 Positive_regulation MAP2K1 CD14 20827308 979277 Positive_regulation MAP2K1 CTGF 16774692 106026 Positive_regulation MAP2K1 CTGF 24637722 2934849 Positive_regulation MAP2K1 CTGF 24637722 2934856 Positive_regulation MAP2K1 EPHB2 10330402 1246198 Positive_regulation MAP2K1 EPHB2 10477763 1249344 Positive_regulation MAP2K1 EPHB2 11309409 1269500 Positive_regulation MAP2K1 EPHB2 11425867 1271715 Positive_regulation MAP2K1 EPHB2 11425867 1271716 Positive_regulation MAP2K1 EPHB2 16351709 1845015 Positive_regulation MAP2K1 EPHB2 17474984 656569 Positive_regulation MAP2K1 EPHB2 18332218 1349878 Positive_regulation MAP2K1 EPHB2 19682393 1646613 Positive_regulation MAP2K1 EPHB2 19707375 175662 Positive_regulation MAP2K1 EPHB2 20838657 2272354 Positive_regulation MAP2K1 EPHB2 21860657 813159 Positive_regulation MAP2K1 EPHB2 22077956 3091389 Positive_regulation MAP2K1 EPHB2 22753777 477715 Positive_regulation MAP2K1 EPHB2 23453810 1878058 Positive_regulation MAP2K1 EPHB2 23617883 1867943 Positive_regulation MAP2K1 EPHB2 23782265 151708 Positive_regulation MAP2K1 EPHB2 24416349 2907654 Positive_regulation MAP2K1 EPHB2 24516336 2249839 Positive_regulation MAP2K1 EPHB2 24608898 2932856 Positive_regulation MAP2K1 EPHB2 25013907 2988108 Positive_regulation MAP2K1 EPHB2 25126479 212374 Positive_regulation MAP2K1 EPHB2 25514788 3034677 Positive_regulation MAP2K1 EPHB2 8996240 1599789 Positive_regulation MAP2K1 EPHB2 8996240 1599818 Positive_regulation MAP2K1 HBEGF 22873932 533001 Positive_regulation MAP2K1 HBEGF 22873932 533040 Positive_regulation MAP2K1 HBEGF 25342939 685345 Positive_regulation MAP2K1 IFI27 21114830 403448 Positive_regulation MAP2K1 LBP 20150966 1213529 Positive_regulation MAP2K1 MAP2K6 12876277 1294748 Positive_regulation MAP2K1 MAP2K6 22069624 3182811 Positive_regulation MAP2K1 MAP2K6 23524590 218341 Positive_regulation MAP2K1 MAP2K6 23826126 2810480 Positive_regulation MAP2K1 MUC16 17391532 3108057 Positive_regulation MAP2K1 TLR7 20832340 1040224 Positive_regulation MAP2K1 TLR7 22577336 3128485 Positive_regulation MAP2K1 TNF 19808894 711205 Positive_regulation MAP2K1 TNF 19808894 711206 Positive_regulation MAP2K1 TNF 19808894 711388 Positive_regulation MAP2K1 TNF 20624904 1377601 Positive_regulation MAP2K1 TNF 23150750 2225208 Positive_regulation MAP2K2 CCND1 22833568 1806097 Positive_regulation MAP2K2 CD14 20827308 979279 Positive_regulation MAP2K2 CTGF 16774692 106027 Positive_regulation MAP2K2 CTGF 24637722 2934850 Positive_regulation MAP2K2 CTGF 24637722 2934857 Positive_regulation MAP2K2 EPHB2 10477763 1249345 Positive_regulation MAP2K2 EPHB2 11309409 1269501 Positive_regulation MAP2K2 EPHB2 16351709 1845017 Positive_regulation MAP2K2 EPHB2 17474984 656571 Positive_regulation MAP2K2 EPHB2 18332218 1349882 Positive_regulation MAP2K2 EPHB2 19682393 1646614 Positive_regulation MAP2K2 EPHB2 19707375 175663 Positive_regulation MAP2K2 EPHB2 21860657 813160 Positive_regulation MAP2K2 EPHB2 22077956 3091390 Positive_regulation MAP2K2 EPHB2 22753777 477716 Positive_regulation MAP2K2 EPHB2 23617883 1867945 Positive_regulation MAP2K2 EPHB2 23782265 151709 Positive_regulation MAP2K2 EPHB2 24416349 2907655 Positive_regulation MAP2K2 EPHB2 24516336 2249840 Positive_regulation MAP2K2 EPHB2 24608898 2932857 Positive_regulation MAP2K2 EPHB2 25013907 2988109 Positive_regulation MAP2K2 EPHB2 25126479 212375 Positive_regulation MAP2K2 EPHB2 25514788 3034678 Positive_regulation MAP2K2 EPHB2 8996240 1599790 Positive_regulation MAP2K2 EPHB2 8996240 1599819 Positive_regulation MAP2K2 HBEGF 22873932 533003 Positive_regulation MAP2K2 HBEGF 22873932 533042 Positive_regulation MAP2K2 HBEGF 25342939 685346 Positive_regulation MAP2K2 IFI27 21114830 403449 Positive_regulation MAP2K2 MAP2K6 23524590 218349 Positive_regulation MAP2K2 MMP28 22318515 1988240 Positive_regulation MAP2K2 MMP7 22318515 1988255 Positive_regulation MAP2K2 MUC16 17391532 3108072 Positive_regulation MAP2K2 TLR7 20832340 1040225 Positive_regulation MAP2K2 TLR7 22577336 3128496 Positive_regulation MAP2K2 TNF 19808894 711211 Positive_regulation MAP2K2 TNF 19808894 711212 Positive_regulation MAP2K2 TNF 19808894 711390 Positive_regulation MAP2K2 TNF 20624904 1377603 Positive_regulation MAP2K3 CCND1 22833568 1806098 Positive_regulation MAP2K3 CD14 20827308 979281 Positive_regulation MAP2K3 CTGF 16774692 106028 Positive_regulation MAP2K3 CTGF 24637722 2934851 Positive_regulation MAP2K3 CTGF 24637722 2934858 Positive_regulation MAP2K3 EPHB2 10477763 1249346 Positive_regulation MAP2K3 EPHB2 11309409 1269502 Positive_regulation MAP2K3 EPHB2 17474984 656573 Positive_regulation MAP2K3 EPHB2 18332218 1349886 Positive_regulation MAP2K3 EPHB2 19682393 1646615 Positive_regulation MAP2K3 EPHB2 19707375 175664 Positive_regulation MAP2K3 EPHB2 21860657 813161 Positive_regulation MAP2K3 EPHB2 22077956 3091391 Positive_regulation MAP2K3 EPHB2 22753777 477717 Positive_regulation MAP2K3 EPHB2 23617883 1867947 Positive_regulation MAP2K3 EPHB2 23782265 151710 Positive_regulation MAP2K3 EPHB2 24416349 2907656 Positive_regulation MAP2K3 EPHB2 24516336 2249841 Positive_regulation MAP2K3 EPHB2 24608898 2932858 Positive_regulation MAP2K3 EPHB2 25013907 2988110 Positive_regulation MAP2K3 EPHB2 25126479 212376 Positive_regulation MAP2K3 EPHB2 25514788 3034679 Positive_regulation MAP2K3 EPHB2 8996240 1599791 Positive_regulation MAP2K3 EPHB2 8996240 1599820 Positive_regulation MAP2K3 HBEGF 22873932 533005 Positive_regulation MAP2K3 HBEGF 22873932 533044 Positive_regulation MAP2K3 HBEGF 25342939 685347 Positive_regulation MAP2K3 IFI27 21114830 403450 Positive_regulation MAP2K3 ITGB2 21206905 2491101 Positive_regulation MAP2K3 MAP2K6 20463961 2449816 Positive_regulation MAP2K3 MAP2K6 20955562 120642 Positive_regulation MAP2K3 MUC16 17391532 3108087 Positive_regulation MAP2K3 TLR7 20832340 1040226 Positive_regulation MAP2K3 TLR7 22577336 3128507 Positive_regulation MAP2K3 TNF 19808894 711217 Positive_regulation MAP2K3 TNF 19808894 711218 Positive_regulation MAP2K3 TNF 19808894 711392 Positive_regulation MAP2K3 TNF 20624904 1377605 Positive_regulation MAP2K4 CCND1 22833568 1806099 Positive_regulation MAP2K4 CD14 20827308 979283 Positive_regulation MAP2K4 CTGF 16774692 106029 Positive_regulation MAP2K4 CTGF 24637722 2934852 Positive_regulation MAP2K4 CTGF 24637722 2934859 Positive_regulation MAP2K4 EPHB2 10477763 1249347 Positive_regulation MAP2K4 EPHB2 11309409 1269503 Positive_regulation MAP2K4 EPHB2 17474984 656575 Positive_regulation MAP2K4 EPHB2 18332218 1349890 Positive_regulation MAP2K4 EPHB2 19682393 1646616 Positive_regulation MAP2K4 EPHB2 19707375 175665 Positive_regulation MAP2K4 EPHB2 21860657 813162 Positive_regulation MAP2K4 EPHB2 22077956 3091392 Positive_regulation MAP2K4 EPHB2 22753777 477718 Positive_regulation MAP2K4 EPHB2 23617883 1867949 Positive_regulation MAP2K4 EPHB2 23782265 151711 Positive_regulation MAP2K4 EPHB2 24416349 2907657 Positive_regulation MAP2K4 EPHB2 24516336 2249842 Positive_regulation MAP2K4 EPHB2 24608898 2932859 Positive_regulation MAP2K4 EPHB2 25013907 2988111 Positive_regulation MAP2K4 EPHB2 25126479 212377 Positive_regulation MAP2K4 EPHB2 25514788 3034680 Positive_regulation MAP2K4 EPHB2 8996240 1599792 Positive_regulation MAP2K4 EPHB2 8996240 1599821 Positive_regulation MAP2K4 HBEGF 22873932 533007 Positive_regulation MAP2K4 HBEGF 22873932 533046 Positive_regulation MAP2K4 HBEGF 25342939 685348 Positive_regulation MAP2K4 IFI27 21114830 403451 Positive_regulation MAP2K4 MAP2K6 20550965 158593 Positive_regulation MAP2K4 MAP2K6 23046544 3161179 Positive_regulation MAP2K4 MAP2K6 24771982 1758272 Positive_regulation MAP2K4 MMP28 22353730 124764 Positive_regulation MAP2K4 MMP7 22353730 124779 Positive_regulation MAP2K4 MUC16 17391532 3108102 Positive_regulation MAP2K4 PLAU 24466137 2913680 Positive_regulation MAP2K4 TLR7 20832340 1040227 Positive_regulation MAP2K4 TLR7 22577336 3128518 Positive_regulation MAP2K4 TNF 19808894 711223 Positive_regulation MAP2K4 TNF 19808894 711224 Positive_regulation MAP2K4 TNF 19808894 711394 Positive_regulation MAP2K4 TNF 20624904 1377607 Positive_regulation MAP2K4 TNF 24842373 1576398 Positive_regulation MAP2K4 TNF 24842373 1576399 Positive_regulation MAP2K5 CCND1 22833568 1806100 Positive_regulation MAP2K5 CD14 20827308 979285 Positive_regulation MAP2K5 CTGF 16774692 106030 Positive_regulation MAP2K5 CTGF 24637722 2934853 Positive_regulation MAP2K5 CTGF 24637722 2934860 Positive_regulation MAP2K5 EPHB2 10477763 1249348 Positive_regulation MAP2K5 EPHB2 11309409 1269504 Positive_regulation MAP2K5 EPHB2 17474984 656577 Positive_regulation MAP2K5 EPHB2 18332218 1349894 Positive_regulation MAP2K5 EPHB2 19682393 1646617 Positive_regulation MAP2K5 EPHB2 19707375 175666 Positive_regulation MAP2K5 EPHB2 21860657 813163 Positive_regulation MAP2K5 EPHB2 22077956 3091393 Positive_regulation MAP2K5 EPHB2 22753777 477719 Positive_regulation MAP2K5 EPHB2 23617883 1867951 Positive_regulation MAP2K5 EPHB2 23782265 151712 Positive_regulation MAP2K5 EPHB2 24416349 2907658 Positive_regulation MAP2K5 EPHB2 24516336 2249843 Positive_regulation MAP2K5 EPHB2 24608898 2932860 Positive_regulation MAP2K5 EPHB2 25013907 2988112 Positive_regulation MAP2K5 EPHB2 25126479 212378 Positive_regulation MAP2K5 EPHB2 25514788 3034681 Positive_regulation MAP2K5 EPHB2 8996240 1599793 Positive_regulation MAP2K5 EPHB2 8996240 1599822 Positive_regulation MAP2K5 HBEGF 22873932 533009 Positive_regulation MAP2K5 HBEGF 22873932 533048 Positive_regulation MAP2K5 HBEGF 25342939 685349 Positive_regulation MAP2K5 IFI27 21114830 403452 Positive_regulation MAP2K5 MUC16 17391532 3108117 Positive_regulation MAP2K5 TLR7 20832340 1040228 Positive_regulation MAP2K5 TLR7 22577336 3128529 Positive_regulation MAP2K5 TNF 19808894 711229 Positive_regulation MAP2K5 TNF 19808894 711230 Positive_regulation MAP2K5 TNF 19808894 711396 Positive_regulation MAP2K5 TNF 20624904 1377609 Positive_regulation MAP2K6 ACD 25118589 1944741 Positive_regulation MAP2K6 ACPP 22563495 2626932 Positive_regulation MAP2K6 ADAM17 24097797 1034417 Positive_regulation MAP2K6 AHSA1 20300552 1672039 Positive_regulation MAP2K6 AHSA1 9314533 1463472 Positive_regulation MAP2K6 AIRE 21364986 2504719 Positive_regulation MAP2K6 AKT1 12838322 422798 Positive_regulation MAP2K6 AKT1 14577832 3095232 Positive_regulation MAP2K6 AKT1 21738574 2532754 Positive_regulation MAP2K6 AKT1 22802915 2219581 Positive_regulation MAP2K6 AKT1 23039341 1867188 Positive_regulation MAP2K6 AKT1 23986655 931110 Positive_regulation MAP2K6 AKT1 24036604 2184839 Positive_regulation MAP2K6 AKT1 24312008 868004 Positive_regulation MAP2K6 AKT1S1 23624914 2152132 Positive_regulation MAP2K6 AKT2 12838322 422799 Positive_regulation MAP2K6 AKT2 14577832 3095233 Positive_regulation MAP2K6 AKT2 21738574 2532755 Positive_regulation MAP2K6 AKT2 22802915 2219582 Positive_regulation MAP2K6 AKT2 23039341 1867189 Positive_regulation MAP2K6 AKT2 23986655 931111 Positive_regulation MAP2K6 AKT2 24036604 2184840 Positive_regulation MAP2K6 AKT2 24312008 868005 Positive_regulation MAP2K6 AKT3 12838322 422800 Positive_regulation MAP2K6 AKT3 14577832 3095234 Positive_regulation MAP2K6 AKT3 21738574 2532756 Positive_regulation MAP2K6 AKT3 22802915 2219583 Positive_regulation MAP2K6 AKT3 23039341 1867190 Positive_regulation MAP2K6 AKT3 23986655 931112 Positive_regulation MAP2K6 AKT3 24036604 2184841 Positive_regulation MAP2K6 AKT3 24312008 868006 Positive_regulation MAP2K6 ALK 22852078 1689221 Positive_regulation MAP2K6 ANXA6 23599172 2183047 Positive_regulation MAP2K6 APLN 24227918 1916436 Positive_regulation MAP2K6 APP 24481061 1123555 Positive_regulation MAP2K6 ARG1 22348022 2596467 Positive_regulation MAP2K6 ARG2 22348022 2596468 Positive_regulation MAP2K6 AURKA 25074438 1702355 Positive_regulation MAP2K6 AURKA 25074438 1702399 Positive_regulation MAP2K6 BCR 24917786 932055 Positive_regulation MAP2K6 BRAF 15149544 241437 Positive_regulation MAP2K6 BRAF 16846534 459995 Positive_regulation MAP2K6 BRAF 17958888 1242718 Positive_regulation MAP2K6 BRAF 18332218 1349895 Positive_regulation MAP2K6 BRAF 18332218 1349896 Positive_regulation MAP2K6 BRAF 19828018 1696432 Positive_regulation MAP2K6 BRAF 20141835 516331 Positive_regulation MAP2K6 BRAF 20141835 516366 Positive_regulation MAP2K6 BRAF 21203386 2489596 Positive_regulation MAP2K6 BRAF 21437184 2234277 Positive_regulation MAP2K6 BRAF 21479172 2510944 Positive_regulation MAP2K6 BRAF 22035226 528013 Positive_regulation MAP2K6 BRAF 22529971 2620792 Positive_regulation MAP2K6 BRAF 22753777 477712 Positive_regulation MAP2K6 BRAF 23085539 2181445 Positive_regulation MAP2K6 BRAF 23208503 2150116 Positive_regulation MAP2K6 BRAF 24810962 2190425 Positive_regulation MAP2K6 BRAF 24817905 656816 Positive_regulation MAP2K6 BRAF 24918056 853909 Positive_regulation MAP2K6 BRAF 24937142 851419 Positive_regulation MAP2K6 BRAF 25074438 1702398 Positive_regulation MAP2K6 BRAF 25228592 2200196 Positive_regulation MAP2K6 BRAF 25228592 2200210 Positive_regulation MAP2K6 BRAF 25505733 948936 Positive_regulation MAP2K6 BRD7 19949542 672210 Positive_regulation MAP2K6 CA2 18404483 3087953 Positive_regulation MAP2K6 CA2 22043200 667813 Positive_regulation MAP2K6 CARD11 22303480 2594939 Positive_regulation MAP2K6 CASP3 24023725 2843420 Positive_regulation MAP2K6 CCL5 22506069 2618360 Positive_regulation MAP2K6 CCNA2 25187756 484823 Positive_regulation MAP2K6 CCNB1 11238451 1267681 Positive_regulation MAP2K6 CCNB2 11238451 1267682 Positive_regulation MAP2K6 CCND1 22833568 1806101 Positive_regulation MAP2K6 CD14 20827308 979287 Positive_regulation MAP2K6 CD24 22400115 154697 Positive_regulation MAP2K6 CD274 20814675 488036 Positive_regulation MAP2K6 CD40 23524590 218354 Positive_regulation MAP2K6 CDC73 8642312 1596834 Positive_regulation MAP2K6 CDH1 22543706 14715 Positive_regulation MAP2K6 CDH1 22543706 14732 Positive_regulation MAP2K6 CDH1 22543706 14747 Positive_regulation MAP2K6 CDH1 22543706 14778 Positive_regulation MAP2K6 CDH1 22543706 14779 Positive_regulation MAP2K6 CDK1 11238451 1267683 Positive_regulation MAP2K6 CDK1 20026657 1369839 Positive_regulation MAP2K6 CDK2 20026657 1369840 Positive_regulation MAP2K6 CDK9 22035226 528052 Positive_regulation MAP2K6 CDKN1A 23006971 2181085 Positive_regulation MAP2K6 COL1A1 24011378 3114048 Positive_regulation MAP2K6 COL1A2 24011378 3114049 Positive_regulation MAP2K6 CREB1 25365078 2206665 Positive_regulation MAP2K6 CREB3 25365078 2206666 Positive_regulation MAP2K6 CREB5 25365078 2206664 Positive_regulation MAP2K6 CRK 20550965 158603 Positive_regulation MAP2K6 CRK 24553827 85146 Positive_regulation MAP2K6 CROT 21107320 1986747 Positive_regulation MAP2K6 CROT 21505228 2175902 Positive_regulation MAP2K6 CSF1 22028782 2564131 Positive_regulation MAP2K6 CSF1 22028782 2564132 Positive_regulation MAP2K6 CSF1 22028782 2564157 Positive_regulation MAP2K6 CSF1 22028782 2564183 Positive_regulation MAP2K6 CSF1 22028782 2564211 Positive_regulation MAP2K6 CSF1 22028782 2564249 Positive_regulation MAP2K6 CSF1 22028782 2564259 Positive_regulation MAP2K6 CSF1 22028782 2564274 Positive_regulation MAP2K6 CSF1 22028782 2564292 Positive_regulation MAP2K6 CSF1 22873932 532974 Positive_regulation MAP2K6 CSF2 20838657 2272405 Positive_regulation MAP2K6 CSF2 24040362 2846948 Positive_regulation MAP2K6 CTGF 16774692 106031 Positive_regulation MAP2K6 CTGF 24637722 2934854 Positive_regulation MAP2K6 CTGF 24637722 2934861 Positive_regulation MAP2K6 CTR9 8642312 1596835 Positive_regulation MAP2K6 CUL4A 23272222 2730202 Positive_regulation MAP2K6 CXCL12 23840250 820705 Positive_regulation MAP2K6 CXCR4 23840250 820706 Positive_regulation MAP2K6 CYP2E1 22028977 1078814 Positive_regulation MAP2K6 DAG1 20625412 1215630 Positive_regulation MAP2K6 DERL1 24667437 2938755 Positive_regulation MAP2K6 DLK1 23840193 878954 Positive_regulation MAP2K6 DLK1 23840193 878965 Positive_regulation MAP2K6 DPYS 20161735 2440535 Positive_regulation MAP2K6 DPYS 20161735 2440543 Positive_regulation MAP2K6 DUSP6 19897477 1167245 Positive_regulation MAP2K6 ECM1 20507556 855030 Positive_regulation MAP2K6 ECM1 22802915 2219577 Positive_regulation MAP2K6 ECM2 20507556 855031 Positive_regulation MAP2K6 ECM2 22802915 2219578 Positive_regulation MAP2K6 EDN1 20507556 855032 Positive_regulation MAP2K6 EDN1 22802915 2219579 Positive_regulation MAP2K6 EDN1 24823877 1126569 Positive_regulation MAP2K6 EDNRA 22802915 2219580 Positive_regulation MAP2K6 EGF 11238463 1267804 Positive_regulation MAP2K6 EGF 11461094 419506 Positive_regulation MAP2K6 EGF 15870831 426096 Positive_regulation MAP2K6 EGF 18004277 1902507 Positive_regulation MAP2K6 EGF 18335053 2387087 Positive_regulation MAP2K6 EGF 19357636 1902948 Positive_regulation MAP2K6 EGF 20624904 1377612 Positive_regulation MAP2K6 EGF 22873932 533012 Positive_regulation MAP2K6 EGF 22873932 533051 Positive_regulation MAP2K6 EGF 22905119 2675288 Positive_regulation MAP2K6 EGF 23105109 1205417 Positive_regulation MAP2K6 EGF 23105109 1205452 Positive_regulation MAP2K6 EGF 23955284 161253 Positive_regulation MAP2K6 EGF 24240988 1939537 Positive_regulation MAP2K6 EGF 25246767 743235 Positive_regulation MAP2K6 EGF 25246767 743258 Positive_regulation MAP2K6 EGF 25514808 3034951 Positive_regulation MAP2K6 EGFR 18460189 2232710 Positive_regulation MAP2K6 EGFR 21534086 1693964 Positive_regulation MAP2K6 EGFR 22043994 91925 Positive_regulation MAP2K6 EGFR 22294553 777855 Positive_regulation MAP2K6 EGFR 22294553 777856 Positive_regulation MAP2K6 EGFR 22645717 939681 Positive_regulation MAP2K6 EGFR 22984397 2688291 Positive_regulation MAP2K6 EGFR 22984397 2688302 Positive_regulation MAP2K6 EGFR 22984397 2688323 Positive_regulation MAP2K6 EGFR 22988500 1689652 Positive_regulation MAP2K6 EGFR 23076445 2171062 Positive_regulation MAP2K6 EGFR 23344022 1100596 Positive_regulation MAP2K6 EGFR 23552555 2155926 Positive_regulation MAP2K6 EGFR 23554829 818337 Positive_regulation MAP2K6 EGFR 23617883 1867952 Positive_regulation MAP2K6 EGFR 23762360 2803120 Positive_regulation MAP2K6 EGFR 24807215 1942007 Positive_regulation MAP2K6 EGR1 23468876 2759914 Positive_regulation MAP2K6 EIF2AK2 23202496 3221820 Positive_regulation MAP2K6 EPHB2 10330402 1246213 Positive_regulation MAP2K6 EPHB2 10477763 1249349 Positive_regulation MAP2K6 EPHB2 11309409 1269505 Positive_regulation MAP2K6 EPHB2 17474984 656579 Positive_regulation MAP2K6 EPHB2 18332218 1349898 Positive_regulation MAP2K6 EPHB2 19682393 1646618 Positive_regulation MAP2K6 EPHB2 19707375 175667 Positive_regulation MAP2K6 EPHB2 21860657 813164 Positive_regulation MAP2K6 EPHB2 22077956 3091394 Positive_regulation MAP2K6 EPHB2 22753777 477720 Positive_regulation MAP2K6 EPHB2 23617883 1867953 Positive_regulation MAP2K6 EPHB2 23782265 151713 Positive_regulation MAP2K6 EPHB2 24416349 2907659 Positive_regulation MAP2K6 EPHB2 24516336 2249844 Positive_regulation MAP2K6 EPHB2 24608898 2932861 Positive_regulation MAP2K6 EPHB2 25013907 2988113 Positive_regulation MAP2K6 EPHB2 25126479 212379 Positive_regulation MAP2K6 EPHB2 25514788 3034682 Positive_regulation MAP2K6 EPHB2 8996240 1599794 Positive_regulation MAP2K6 EPHB2 8996240 1599823 Positive_regulation MAP2K6 EPO 15149544 241438 Positive_regulation MAP2K6 EPX 15149544 241486 Positive_regulation MAP2K6 ERBB2 21576761 2175963 Positive_regulation MAP2K6 ERBB2 25193864 2199061 Positive_regulation MAP2K6 FAS 9362518 1464802 Positive_regulation MAP2K6 FGF1 23145076 2715710 Positive_regulation MAP2K6 FGF1 23226437 2724929 Positive_regulation MAP2K6 FGF1 25514808 3034952 Positive_regulation MAP2K6 FGF10 23145076 2715711 Positive_regulation MAP2K6 FGF10 23226437 2724930 Positive_regulation MAP2K6 FGF10 25514808 3034953 Positive_regulation MAP2K6 FGF11 23145076 2715712 Positive_regulation MAP2K6 FGF11 23226437 2724931 Positive_regulation MAP2K6 FGF11 25514808 3034954 Positive_regulation MAP2K6 FGF12 23145076 2715713 Positive_regulation MAP2K6 FGF12 23226437 2724932 Positive_regulation MAP2K6 FGF12 25514808 3034955 Positive_regulation MAP2K6 FGF13 23145076 2715714 Positive_regulation MAP2K6 FGF13 23226437 2724933 Positive_regulation MAP2K6 FGF13 25514808 3034956 Positive_regulation MAP2K6 FGF14 23145076 2715715 Positive_regulation MAP2K6 FGF14 23226437 2724934 Positive_regulation MAP2K6 FGF14 25514808 3034957 Positive_regulation MAP2K6 FGF16 23145076 2715716 Positive_regulation MAP2K6 FGF16 23226437 2724935 Positive_regulation MAP2K6 FGF16 25514808 3034958 Positive_regulation MAP2K6 FGF17 23145076 2715717 Positive_regulation MAP2K6 FGF17 23226437 2724936 Positive_regulation MAP2K6 FGF17 25514808 3034959 Positive_regulation MAP2K6 FGF18 23145076 2715718 Positive_regulation MAP2K6 FGF18 23226437 2724937 Positive_regulation MAP2K6 FGF18 25514808 3034960 Positive_regulation MAP2K6 FGF19 23145076 2715719 Positive_regulation MAP2K6 FGF19 23226437 2724938 Positive_regulation MAP2K6 FGF19 25514808 3034961 Positive_regulation MAP2K6 FGF2 20886037 2476121 Positive_regulation MAP2K6 FGF2 22294553 777962 Positive_regulation MAP2K6 FGF2 23145076 2715720 Positive_regulation MAP2K6 FGF2 23226437 2724939 Positive_regulation MAP2K6 FGF2 23349801 2743273 Positive_regulation MAP2K6 FGF2 24649403 853706 Positive_regulation MAP2K6 FGF2 24880876 1964771 Positive_regulation MAP2K6 FGF2 25295214 1692981 Positive_regulation MAP2K6 FGF2 25514808 3034962 Positive_regulation MAP2K6 FGF20 23145076 2715721 Positive_regulation MAP2K6 FGF20 23226437 2724940 Positive_regulation MAP2K6 FGF20 25514808 3034963 Positive_regulation MAP2K6 FGF21 23145076 2715722 Positive_regulation MAP2K6 FGF21 23226437 2724941 Positive_regulation MAP2K6 FGF21 25514808 3034964 Positive_regulation MAP2K6 FGF22 23145076 2715723 Positive_regulation MAP2K6 FGF22 23226437 2724942 Positive_regulation MAP2K6 FGF22 25514808 3034965 Positive_regulation MAP2K6 FGF23 23145076 2715724 Positive_regulation MAP2K6 FGF23 23226437 2724943 Positive_regulation MAP2K6 FGF23 25514808 3034966 Positive_regulation MAP2K6 FGF3 23145076 2715725 Positive_regulation MAP2K6 FGF3 23226437 2724944 Positive_regulation MAP2K6 FGF3 25514808 3034967 Positive_regulation MAP2K6 FGF4 23145076 2715726 Positive_regulation MAP2K6 FGF4 23213424 168759 Positive_regulation MAP2K6 FGF4 23226437 2724945 Positive_regulation MAP2K6 FGF4 25514808 3034968 Positive_regulation MAP2K6 FGF5 23145076 2715727 Positive_regulation MAP2K6 FGF5 23226437 2724946 Positive_regulation MAP2K6 FGF5 25514808 3034969 Positive_regulation MAP2K6 FGF6 23145076 2715728 Positive_regulation MAP2K6 FGF6 23226437 2724947 Positive_regulation MAP2K6 FGF6 25514808 3034970 Positive_regulation MAP2K6 FGF7 23145076 2715729 Positive_regulation MAP2K6 FGF7 23226437 2724948 Positive_regulation MAP2K6 FGF7 25514808 3034971 Positive_regulation MAP2K6 FGF8 23145076 2715730 Positive_regulation MAP2K6 FGF8 23226437 2724949 Positive_regulation MAP2K6 FGF8 25514808 3034972 Positive_regulation MAP2K6 FGF9 23145076 2715731 Positive_regulation MAP2K6 FGF9 23226437 2724950 Positive_regulation MAP2K6 FGF9 25514808 3034973 Positive_regulation MAP2K6 FGFR1 17277739 1906366 Positive_regulation MAP2K6 FGFR2 17277739 1906367 Positive_regulation MAP2K6 FGFR3 17277739 1906368 Positive_regulation MAP2K6 FGFR4 17277739 1906369 Positive_regulation MAP2K6 FIGF 21693010 468395 Positive_regulation MAP2K6 FLT4 22745786 2656466 Positive_regulation MAP2K6 FN1 24489856 2916520 Positive_regulation MAP2K6 FNTA 19404317 1719367 Positive_regulation MAP2K6 FNTB 19404317 1719368 Positive_regulation MAP2K6 GAB1 21408212 2292273 Positive_regulation MAP2K6 GABPA 24260034 25050 Positive_regulation MAP2K6 GDF15 21798071 508590 Positive_regulation MAP2K6 GDNF 23468876 2759915 Positive_regulation MAP2K6 GNAQ 22808163 2664928 Positive_regulation MAP2K6 GNRH1 22808094 2664335 Positive_regulation MAP2K6 GNRHR 20688134 1880914 Positive_regulation MAP2K6 GRAP2 10330402 1246214 Positive_regulation MAP2K6 GRAP2 22569127 771784 Positive_regulation MAP2K6 GRB2 18404483 3087954 Positive_regulation MAP2K6 GRB2 18521338 3127500 Positive_regulation MAP2K6 GRB2 21408212 2292274 Positive_regulation MAP2K6 GRB2 24709879 617269 Positive_regulation MAP2K6 GRB2 24775912 1874110 Positive_regulation MAP2K6 HBEGF 22873932 533011 Positive_regulation MAP2K6 HBEGF 22873932 533050 Positive_regulation MAP2K6 HBEGF 25342939 685350 Positive_regulation MAP2K6 HGF 16275761 1538253 Positive_regulation MAP2K6 HGF 23267331 960608 Positive_regulation MAP2K6 HMGB1 24058610 2848269 Positive_regulation MAP2K6 HMGCR 19404317 1719369 Positive_regulation MAP2K6 HNRNPF 21544193 2517155 Positive_regulation MAP2K6 HNRNPH1 21544193 2517156 Positive_regulation MAP2K6 HRAS 17498287 999328 Positive_regulation MAP2K6 HRAS 19238206 2406142 Positive_regulation MAP2K6 HRAS 19319189 2408580 Positive_regulation MAP2K6 HRAS 19707311 175394 Positive_regulation MAP2K6 HRAS 20003375 254834 Positive_regulation MAP2K6 HRAS 20071468 1772957 Positive_regulation MAP2K6 HRAS 21072183 2481299 Positive_regulation MAP2K6 HRAS 21403829 2234259 Positive_regulation MAP2K6 HRAS 21479172 2510931 Positive_regulation MAP2K6 HRAS 21831290 1505422 Positive_regulation MAP2K6 HRAS 21994767 3220316 Positive_regulation MAP2K6 HRAS 22463874 1506290 Positive_regulation MAP2K6 HRAS 22971289 472147 Positive_regulation MAP2K6 HRAS 23587357 734365 Positive_regulation MAP2K6 HRAS 23675062 1064418 Positive_regulation MAP2K6 HRAS 23758320 151538 Positive_regulation MAP2K6 HRAS 23825558 2809675 Positive_regulation MAP2K6 HRAS 24223225 2876753 Positive_regulation MAP2K6 HRAS 24231770 545262 Positive_regulation MAP2K6 HRAS 24265712 2885002 Positive_regulation MAP2K6 HRAS 24643257 2285899 Positive_regulation MAP2K6 HRAS 24684778 1873616 Positive_regulation MAP2K6 HRAS 25478577 201734 Positive_regulation MAP2K6 HRG 18004277 1902414 Positive_regulation MAP2K6 HRG 18004277 1902517 Positive_regulation MAP2K6 HRG 22216327 2585638 Positive_regulation MAP2K6 HRH4 22569158 1662293 Positive_regulation MAP2K6 HSPG2 20071468 1773086 Positive_regulation MAP2K6 ICAM1 16780590 249459 Positive_regulation MAP2K6 IFI27 21114830 403453 Positive_regulation MAP2K6 IGF1 22470194 2179957 Positive_regulation MAP2K6 IGF1 24282611 2886440 Positive_regulation MAP2K6 IGF1 24282611 2886489 Positive_regulation MAP2K6 IGF1 24507165 1770092 Positive_regulation MAP2K6 IGF1R 21505228 2175861 Positive_regulation MAP2K6 IGF1R 24353828 2115359 Positive_regulation MAP2K6 IGF2 22470194 2179958 Positive_regulation MAP2K6 IGF2 24282611 2886441 Positive_regulation MAP2K6 IGFBP5 24551065 2922949 Positive_regulation MAP2K6 IGKV6D-21 23840250 820707 Positive_regulation MAP2K6 IL17A 16504032 392048 Positive_regulation MAP2K6 IL1A 19808894 711237 Positive_regulation MAP2K6 IL1A 19808894 711238 Positive_regulation MAP2K6 IL1A 19808894 711399 Positive_regulation MAP2K6 IL1A 20380881 1881313 Positive_regulation MAP2K6 IL1A 20955562 120288 Positive_regulation MAP2K6 IL1A 20955562 120289 Positive_regulation MAP2K6 IL1A 20955562 120290 Positive_regulation MAP2K6 IL1A 20955562 120359 Positive_regulation MAP2K6 IL1A 20955562 120697 Positive_regulation MAP2K6 IL1A 21408212 2292224 Positive_regulation MAP2K6 IL2 17623099 320680 Positive_regulation MAP2K6 IL3 22873932 532975 Positive_regulation MAP2K6 IL5 25121926 2997422 Positive_regulation MAP2K6 IL6 23093834 1225130 Positive_regulation MAP2K6 IL6ST 22035226 528053 Positive_regulation MAP2K6 IL8 24598028 272063 Positive_regulation MAP2K6 INS 18521338 3127501 Positive_regulation MAP2K6 INS 19808894 711239 Positive_regulation MAP2K6 INS 19808894 711417 Positive_regulation MAP2K6 INS 21286247 1028360 Positive_regulation MAP2K6 INS 23437362 2756605 Positive_regulation MAP2K6 INS 23847619 908129 Positive_regulation MAP2K6 INS 24282611 2886490 Positive_regulation MAP2K6 INS 24434591 787605 Positive_regulation MAP2K6 INTS6 17895999 2378822 Positive_regulation MAP2K6 INTS6 17895999 2378859 Positive_regulation MAP2K6 IRS1 18521338 3127502 Positive_regulation MAP2K6 JAK1 23567618 1642640 Positive_regulation MAP2K6 JAK1 24312008 868007 Positive_regulation MAP2K6 JAK2 24312008 868008 Positive_regulation MAP2K6 JAK3 24312008 868009 Positive_regulation MAP2K6 JUN 22606284 2642733 Positive_regulation MAP2K6 JUN 23150750 2225200 Positive_regulation MAP2K6 JUN 24671046 3141206 Positive_regulation MAP2K6 JUN 24803988 2228876 Positive_regulation MAP2K6 KCNN4 25071444 869881 Positive_regulation MAP2K6 KDR 20222950 255583 Positive_regulation MAP2K6 KRAS 17498287 999329 Positive_regulation MAP2K6 KRAS 19238206 2406143 Positive_regulation MAP2K6 KRAS 19707311 175395 Positive_regulation MAP2K6 KRAS 20003375 254835 Positive_regulation MAP2K6 KRAS 20071468 1772958 Positive_regulation MAP2K6 KRAS 21072183 2481300 Positive_regulation MAP2K6 KRAS 21403829 2234260 Positive_regulation MAP2K6 KRAS 21479172 2510932 Positive_regulation MAP2K6 KRAS 21699731 1862548 Positive_regulation MAP2K6 KRAS 21831290 1505423 Positive_regulation MAP2K6 KRAS 22102901 2572129 Positive_regulation MAP2K6 KRAS 22327365 1928217 Positive_regulation MAP2K6 KRAS 22463874 1506291 Positive_regulation MAP2K6 KRAS 22971289 472148 Positive_regulation MAP2K6 KRAS 23587357 734366 Positive_regulation MAP2K6 KRAS 23675062 1064419 Positive_regulation MAP2K6 KRAS 23758320 151539 Positive_regulation MAP2K6 KRAS 23825558 2809676 Positive_regulation MAP2K6 KRAS 24172537 1735827 Positive_regulation MAP2K6 KRAS 24223225 2876754 Positive_regulation MAP2K6 KRAS 24231770 545263 Positive_regulation MAP2K6 KRAS 24265712 2885003 Positive_regulation MAP2K6 KRAS 24643257 2285900 Positive_regulation MAP2K6 KRAS 24684778 1873617 Positive_regulation MAP2K6 KRAS 25478577 201735 Positive_regulation MAP2K6 KSR1 23105109 1205418 Positive_regulation MAP2K6 KSR1 24918056 853911 Positive_regulation MAP2K6 KSR1 24937142 851379 Positive_regulation MAP2K6 LAMTOR3 19930650 526259 Positive_regulation MAP2K6 LAMTOR3 19930650 526290 Positive_regulation MAP2K6 LAMTOR3 19930650 526308 Positive_regulation MAP2K6 LAMTOR3 22776333 532877 Positive_regulation MAP2K6 LEO1 8642312 1596838 Positive_regulation MAP2K6 LEP 23967295 2835501 Positive_regulation MAP2K6 LEP 24371782 1718787 Positive_regulation MAP2K6 LGALS1 21364631 549459 Positive_regulation MAP2K6 LIF 21798094 3160311 Positive_regulation MAP2K6 LIF 22143885 1566364 Positive_regulation MAP2K6 LPA 18404483 3088028 Positive_regulation MAP2K6 MAP2K1 12876277 1294759 Positive_regulation MAP2K6 MAP2K1 22069624 3182815 Positive_regulation MAP2K6 MAP2K1 22606284 2642734 Positive_regulation MAP2K6 MAP2K3 20463961 2449817 Positive_regulation MAP2K6 MAP2K3 20955562 120643 Positive_regulation MAP2K6 MAP2K4 20550965 158594 Positive_regulation MAP2K6 MAP2K4 24771982 1758273 Positive_regulation MAP2K6 MAP2K7 20550965 158595 Positive_regulation MAP2K6 MAP3K1 22852078 1689491 Positive_regulation MAP2K6 MAP3K10 22852078 1689492 Positive_regulation MAP2K6 MAP3K11 22852078 1689493 Positive_regulation MAP2K6 MAP3K11 23552557 2155971 Positive_regulation MAP2K6 MAP3K12 22852078 1689494 Positive_regulation MAP2K6 MAP3K13 22852078 1689495 Positive_regulation MAP2K6 MAP3K13 23552557 2155972 Positive_regulation MAP2K6 MAP3K13 23552557 2155973 Positive_regulation MAP2K6 MAP3K14 22852078 1689496 Positive_regulation MAP2K6 MAP3K15 22852078 1689490 Positive_regulation MAP2K6 MAP3K19 22852078 1689489 Positive_regulation MAP2K6 MAP3K2 22852078 1689497 Positive_regulation MAP2K6 MAP3K3 22852078 1689498 Positive_regulation MAP2K6 MAP3K4 22852078 1689499 Positive_regulation MAP2K6 MAP3K5 19749799 2127009 Positive_regulation MAP2K6 MAP3K5 20550965 158600 Positive_regulation MAP2K6 MAP3K5 20550965 158604 Positive_regulation MAP2K6 MAP3K5 20550965 158605 Positive_regulation MAP2K6 MAP3K5 21368773 988676 Positive_regulation MAP2K6 MAP3K5 22028977 1078801 Positive_regulation MAP2K6 MAP3K5 22852078 1689500 Positive_regulation MAP2K6 MAP3K5 24849047 1942141 Positive_regulation MAP2K6 MAP3K5 25435878 1074872 Positive_regulation MAP2K6 MAP3K6 22852078 1689501 Positive_regulation MAP2K6 MAP3K7 21902831 3160719 Positive_regulation MAP2K6 MAP3K7 22496778 2617451 Positive_regulation MAP2K6 MAP3K7 22566960 900558 Positive_regulation MAP2K6 MAP3K7 22649774 939780 Positive_regulation MAP2K6 MAP3K7 22852078 1689502 Positive_regulation MAP2K6 MAP3K8 19808894 711240 Positive_regulation MAP2K6 MAP3K8 22852078 1689503 Positive_regulation MAP2K6 MAP3K8 24634165 492636 Positive_regulation MAP2K6 MAP3K9 22852078 1689504 Positive_regulation MAP2K6 MAPK1 10330402 1246215 Positive_regulation MAP2K6 MAPK1 16048647 3105266 Positive_regulation MAP2K6 MAPK1 17425806 225605 Positive_regulation MAP2K6 MAPK1 17525795 2013981 Positive_regulation MAP2K6 MAPK1 18949068 2208024 Positive_regulation MAP2K6 MAPK1 19159010 1055360 Positive_regulation MAP2K6 MAPK1 19426550 282481 Positive_regulation MAP2K6 MAPK1 22028883 2564864 Positive_regulation MAP2K6 MAPK1 22870983 289000 Positive_regulation MAP2K6 MAPK1 23936348 2830064 Positive_regulation MAP2K6 MAPK1 24803988 2228877 Positive_regulation MAP2K6 MAPK1 24853429 576305 Positive_regulation MAP2K6 MAPK1 25364728 861756 Positive_regulation MAP2K6 MAPK10 10330402 1246216 Positive_regulation MAP2K6 MAPK10 16048647 3105267 Positive_regulation MAP2K6 MAPK10 17525795 2013982 Positive_regulation MAP2K6 MAPK10 19159010 1055361 Positive_regulation MAP2K6 MAPK10 19426550 282482 Positive_regulation MAP2K6 MAPK10 22028883 2564865 Positive_regulation MAP2K6 MAPK10 22870983 289001 Positive_regulation MAP2K6 MAPK10 23936348 2830065 Positive_regulation MAP2K6 MAPK10 24803988 2228878 Positive_regulation MAP2K6 MAPK10 25364728 861757 Positive_regulation MAP2K6 MAPK11 10330402 1246217 Positive_regulation MAP2K6 MAPK11 16048647 3105268 Positive_regulation MAP2K6 MAPK11 17525795 2013983 Positive_regulation MAP2K6 MAPK11 19159010 1055362 Positive_regulation MAP2K6 MAPK11 19426550 282483 Positive_regulation MAP2K6 MAPK11 22028883 2564866 Positive_regulation MAP2K6 MAPK11 22870983 289002 Positive_regulation MAP2K6 MAPK11 23936348 2830066 Positive_regulation MAP2K6 MAPK11 24803988 2228879 Positive_regulation MAP2K6 MAPK11 25364728 861758 Positive_regulation MAP2K6 MAPK12 10330402 1246218 Positive_regulation MAP2K6 MAPK12 16048647 3105269 Positive_regulation MAP2K6 MAPK12 17525795 2013984 Positive_regulation MAP2K6 MAPK12 19159010 1055363 Positive_regulation MAP2K6 MAPK12 19426550 282484 Positive_regulation MAP2K6 MAPK12 22028883 2564867 Positive_regulation MAP2K6 MAPK12 22870983 289003 Positive_regulation MAP2K6 MAPK12 23936348 2830067 Positive_regulation MAP2K6 MAPK12 24803988 2228880 Positive_regulation MAP2K6 MAPK12 25364728 861759 Positive_regulation MAP2K6 MAPK13 10330402 1246219 Positive_regulation MAP2K6 MAPK13 16048647 3105270 Positive_regulation MAP2K6 MAPK13 17525795 2013985 Positive_regulation MAP2K6 MAPK13 19159010 1055364 Positive_regulation MAP2K6 MAPK13 19426550 282485 Positive_regulation MAP2K6 MAPK13 22028883 2564868 Positive_regulation MAP2K6 MAPK13 22870983 289004 Positive_regulation MAP2K6 MAPK13 23936348 2830068 Positive_regulation MAP2K6 MAPK13 24803988 2228881 Positive_regulation MAP2K6 MAPK13 25364728 861760 Positive_regulation MAP2K6 MAPK14 10330402 1246220 Positive_regulation MAP2K6 MAPK14 16048647 3105271 Positive_regulation MAP2K6 MAPK14 17525795 2013986 Positive_regulation MAP2K6 MAPK14 19159010 1055365 Positive_regulation MAP2K6 MAPK14 19426550 282486 Positive_regulation MAP2K6 MAPK14 22028883 2564869 Positive_regulation MAP2K6 MAPK14 22870983 289005 Positive_regulation MAP2K6 MAPK14 23936348 2830069 Positive_regulation MAP2K6 MAPK14 24803988 2228882 Positive_regulation MAP2K6 MAPK14 25364728 861761 Positive_regulation MAP2K6 MAPK15 10330402 1246212 Positive_regulation MAP2K6 MAPK15 16048647 3105265 Positive_regulation MAP2K6 MAPK15 17525795 2013980 Positive_regulation MAP2K6 MAPK15 19159010 1055359 Positive_regulation MAP2K6 MAPK15 19426550 282480 Positive_regulation MAP2K6 MAPK15 22028883 2564863 Positive_regulation MAP2K6 MAPK15 22870983 288999 Positive_regulation MAP2K6 MAPK15 23936348 2830063 Positive_regulation MAP2K6 MAPK15 24803988 2228875 Positive_regulation MAP2K6 MAPK15 25364728 861755 Positive_regulation MAP2K6 MAPK3 10330402 1246221 Positive_regulation MAP2K6 MAPK3 16048647 3105272 Positive_regulation MAP2K6 MAPK3 17525795 2013987 Positive_regulation MAP2K6 MAPK3 18949068 2208025 Positive_regulation MAP2K6 MAPK3 19159010 1055366 Positive_regulation MAP2K6 MAPK3 19426550 282487 Positive_regulation MAP2K6 MAPK3 19575782 283013 Positive_regulation MAP2K6 MAPK3 22028883 2564870 Positive_regulation MAP2K6 MAPK3 22140566 2576739 Positive_regulation MAP2K6 MAPK3 22870983 289006 Positive_regulation MAP2K6 MAPK3 23936348 2830070 Positive_regulation MAP2K6 MAPK3 24062636 938307 Positive_regulation MAP2K6 MAPK3 24710481 618613 Positive_regulation MAP2K6 MAPK3 24803988 2228883 Positive_regulation MAP2K6 MAPK3 24853429 576306 Positive_regulation MAP2K6 MAPK3 25133186 196783 Positive_regulation MAP2K6 MAPK3 25364728 861762 Positive_regulation MAP2K6 MAPK4 10330402 1246222 Positive_regulation MAP2K6 MAPK4 16048647 3105273 Positive_regulation MAP2K6 MAPK4 17525795 2013988 Positive_regulation MAP2K6 MAPK4 19159010 1055367 Positive_regulation MAP2K6 MAPK4 19426550 282488 Positive_regulation MAP2K6 MAPK4 22028883 2564871 Positive_regulation MAP2K6 MAPK4 22870983 289007 Positive_regulation MAP2K6 MAPK4 23936348 2830071 Positive_regulation MAP2K6 MAPK4 24803988 2228884 Positive_regulation MAP2K6 MAPK4 25364728 861763 Positive_regulation MAP2K6 MAPK6 10330402 1246223 Positive_regulation MAP2K6 MAPK6 16048647 3105274 Positive_regulation MAP2K6 MAPK6 17525795 2013989 Positive_regulation MAP2K6 MAPK6 19159010 1055368 Positive_regulation MAP2K6 MAPK6 19426550 282489 Positive_regulation MAP2K6 MAPK6 22028883 2564872 Positive_regulation MAP2K6 MAPK6 22870983 289008 Positive_regulation MAP2K6 MAPK6 23936348 2830072 Positive_regulation MAP2K6 MAPK6 24803988 2228885 Positive_regulation MAP2K6 MAPK6 25364728 861764 Positive_regulation MAP2K6 MAPK7 10330402 1246224 Positive_regulation MAP2K6 MAPK7 16048647 3105275 Positive_regulation MAP2K6 MAPK7 17525795 2013990 Positive_regulation MAP2K6 MAPK7 19159010 1055369 Positive_regulation MAP2K6 MAPK7 19426550 282490 Positive_regulation MAP2K6 MAPK7 22028883 2564873 Positive_regulation MAP2K6 MAPK7 22870983 289009 Positive_regulation MAP2K6 MAPK7 23936348 2830073 Positive_regulation MAP2K6 MAPK7 24803988 2228886 Positive_regulation MAP2K6 MAPK7 25364728 861765 Positive_regulation MAP2K6 MAPK8 10330402 1246225 Positive_regulation MAP2K6 MAPK8 16048647 3105276 Positive_regulation MAP2K6 MAPK8 17525795 2013991 Positive_regulation MAP2K6 MAPK8 19159010 1055370 Positive_regulation MAP2K6 MAPK8 19426550 282491 Positive_regulation MAP2K6 MAPK8 22028883 2564874 Positive_regulation MAP2K6 MAPK8 22870983 289010 Positive_regulation MAP2K6 MAPK8 23936348 2830074 Positive_regulation MAP2K6 MAPK8 24803988 2228887 Positive_regulation MAP2K6 MAPK8 25364728 861766 Positive_regulation MAP2K6 MAPK9 10330402 1246226 Positive_regulation MAP2K6 MAPK9 16048647 3105277 Positive_regulation MAP2K6 MAPK9 17525795 2013992 Positive_regulation MAP2K6 MAPK9 19159010 1055371 Positive_regulation MAP2K6 MAPK9 19426550 282492 Positive_regulation MAP2K6 MAPK9 22028883 2564875 Positive_regulation MAP2K6 MAPK9 22362764 1201294 Positive_regulation MAP2K6 MAPK9 22870983 289011 Positive_regulation MAP2K6 MAPK9 23936348 2830075 Positive_regulation MAP2K6 MAPK9 24803988 2228888 Positive_regulation MAP2K6 MAPK9 25364728 861767 Positive_regulation MAP2K6 MET 16275761 1538254 Positive_regulation MAP2K6 MET 22745804 2656644 Positive_regulation MAP2K6 MET 24709879 617282 Positive_regulation MAP2K6 MET 24807215 1942008 Positive_regulation MAP2K6 METAP2 22384111 2604290 Positive_regulation MAP2K6 MLST8 23624914 2152131 Positive_regulation MAP2K6 MOCOS 21586168 404919 Positive_regulation MAP2K6 MTOR 21666717 2140075 Positive_regulation MAP2K6 MTOR 23624914 2152134 Positive_regulation MAP2K6 MTOR 24041012 746123 Positive_regulation MAP2K6 MTOR 24810962 2190426 Positive_regulation MAP2K6 MTOR 24810962 2190491 Positive_regulation MAP2K6 MTOR 24939055 1508146 Positive_regulation MAP2K6 MTOR 25180793 3004367 Positive_regulation MAP2K6 MUC1 17391532 3108137 Positive_regulation MAP2K6 MUC1 25245423 2201669 Positive_regulation MAP2K6 MUC12 17391532 3108138 Positive_regulation MAP2K6 MUC13 17391532 3108139 Positive_regulation MAP2K6 MUC15 17391532 3108131 Positive_regulation MAP2K6 MUC16 17391532 3108132 Positive_regulation MAP2K6 MUC17 17391532 3108133 Positive_regulation MAP2K6 MUC19 17391532 3108130 Positive_regulation MAP2K6 MUC2 17391532 3108140 Positive_regulation MAP2K6 MUC20 17391532 3108135 Positive_regulation MAP2K6 MUC21 17391532 3108134 Positive_regulation MAP2K6 MUC22 17391532 3108136 Positive_regulation MAP2K6 MUC4 17391532 3108141 Positive_regulation MAP2K6 MUC6 17391532 3108142 Positive_regulation MAP2K6 MUC7 17391532 3108143 Positive_regulation MAP2K6 MUC8 17391532 3108144 Positive_regulation MAP2K6 MYLIP 23054677 1890321 Positive_regulation MAP2K6 MYLIP 24550252 752910 Positive_regulation MAP2K6 NCK1 24670066 539893 Positive_regulation MAP2K6 NFKB1 16491824 1710832 Positive_regulation MAP2K6 NGF 20376360 2445405 Positive_regulation MAP2K6 NGF 20376360 2445427 Positive_regulation MAP2K6 NGF 22754300 1095899 Positive_regulation MAP2K6 NGF 22931352 1231151 Positive_regulation MAP2K6 NGF 23772401 852290 Positive_regulation MAP2K6 NGF 23772401 852832 Positive_regulation MAP2K6 NGF 24667437 2938722 Positive_regulation MAP2K6 NPM1 22852078 1689222 Positive_regulation MAP2K6 NPPA 20802223 2253133 Positive_regulation MAP2K6 NPPA 20802223 2253134 Positive_regulation MAP2K6 NPPA 20802223 2253151 Positive_regulation MAP2K6 NPPA 20802223 2253168 Positive_regulation MAP2K6 NPPA 20802223 2253171 Positive_regulation MAP2K6 NPPA 20802223 2253172 Positive_regulation MAP2K6 NRAS 17498287 999330 Positive_regulation MAP2K6 NRAS 19238206 2406144 Positive_regulation MAP2K6 NRAS 19707311 175396 Positive_regulation MAP2K6 NRAS 20003375 254836 Positive_regulation MAP2K6 NRAS 20071468 1772959 Positive_regulation MAP2K6 NRAS 21072183 2481301 Positive_regulation MAP2K6 NRAS 21403829 2234261 Positive_regulation MAP2K6 NRAS 21479172 2510933 Positive_regulation MAP2K6 NRAS 21505228 2175941 Positive_regulation MAP2K6 NRAS 21831290 1505424 Positive_regulation MAP2K6 NRAS 22463874 1506292 Positive_regulation MAP2K6 NRAS 22475322 264500 Positive_regulation MAP2K6 NRAS 22971289 472149 Positive_regulation MAP2K6 NRAS 23587357 734367 Positive_regulation MAP2K6 NRAS 23675062 1064420 Positive_regulation MAP2K6 NRAS 23758320 151540 Positive_regulation MAP2K6 NRAS 23825558 2809677 Positive_regulation MAP2K6 NRAS 24223225 2876755 Positive_regulation MAP2K6 NRAS 24231770 545264 Positive_regulation MAP2K6 NRAS 24265712 2885004 Positive_regulation MAP2K6 NRAS 24643257 2285901 Positive_regulation MAP2K6 NRAS 24684778 1873618 Positive_regulation MAP2K6 NRAS 25478577 201736 Positive_regulation MAP2K6 NRTN 21450093 1897982 Positive_regulation MAP2K6 NTS 23437362 2756606 Positive_regulation MAP2K6 PAF1 8642312 1596836 Positive_regulation MAP2K6 PAK1 19015320 1361336 Positive_regulation MAP2K6 PAK1 22776333 532878 Positive_regulation MAP2K6 PAK1 24962779 2193196 Positive_regulation MAP2K6 PAK2 19015320 1361337 Positive_regulation MAP2K6 PAK3 19015320 1361338 Positive_regulation MAP2K6 PAK4 19015320 1361334 Positive_regulation MAP2K6 PAK4 24471762 214349 Positive_regulation MAP2K6 PAK6 19015320 1361335 Positive_regulation MAP2K6 PAK6 23125951 589153 Positive_regulation MAP2K6 PAK7 19015320 1361333 Positive_regulation MAP2K6 PARP1 23209876 3131742 Positive_regulation MAP2K6 PDGFRB 22039466 2565564 Positive_regulation MAP2K6 PDK1 16705314 427702 Positive_regulation MAP2K6 PEBP1 22860010 2670758 Positive_regulation MAP2K6 PEBP1 25147739 413834 Positive_regulation MAP2K6 PHKA2 18404483 3087955 Positive_regulation MAP2K6 PHKA2 18404483 3088161 Positive_regulation MAP2K6 PHKA2 20049170 1671541 Positive_regulation MAP2K6 PI3 11435472 1519587 Positive_regulation MAP2K6 PI3 12838322 422801 Positive_regulation MAP2K6 PI3 15067018 1307703 Positive_regulation MAP2K6 PI3 21401944 304799 Positive_regulation MAP2K6 PI3 24901342 2976834 Positive_regulation MAP2K6 PIK3CA 15149544 241514 Positive_regulation MAP2K6 PIK3CA 18321244 145755 Positive_regulation MAP2K6 PIK3CA 18404465 3087741 Positive_regulation MAP2K6 PIK3CA 20003467 1503969 Positive_regulation MAP2K6 PIK3CA 21258407 2137601 Positive_regulation MAP2K6 PIK3CA 22140566 2576740 Positive_regulation MAP2K6 PIK3CA 22594466 1639792 Positive_regulation MAP2K6 PIK3CA 22860103 2671659 Positive_regulation MAP2K6 PIK3CA 22860103 2671675 Positive_regulation MAP2K6 PIK3CA 23039341 1867191 Positive_regulation MAP2K6 PIK3CA 23125836 952465 Positive_regulation MAP2K6 PIK3CA 23977080 2838294 Positive_regulation MAP2K6 PIK3CA 23986655 931113 Positive_regulation MAP2K6 PIK3CA 24036604 2184842 Positive_regulation MAP2K6 PIK3CA 24041012 746124 Positive_regulation MAP2K6 PIK3CA 24272818 2185605 Positive_regulation MAP2K6 PIK3CA 24312008 868010 Positive_regulation MAP2K6 PIK3CA 24577313 1124440 Positive_regulation MAP2K6 PIK3CA 24795729 912609 Positive_regulation MAP2K6 PIK3CA 24810962 2190427 Positive_regulation MAP2K6 PIK3CA 24939055 1508147 Positive_regulation MAP2K6 PIK3R1 15149544 241515 Positive_regulation MAP2K6 PIK3R1 18321244 145756 Positive_regulation MAP2K6 PIK3R1 18404465 3087742 Positive_regulation MAP2K6 PIK3R1 20003467 1503970 Positive_regulation MAP2K6 PIK3R1 21258407 2137602 Positive_regulation MAP2K6 PIK3R1 22140566 2576741 Positive_regulation MAP2K6 PIK3R1 22594466 1639793 Positive_regulation MAP2K6 PIK3R1 22860103 2671660 Positive_regulation MAP2K6 PIK3R1 22860103 2671676 Positive_regulation MAP2K6 PIK3R1 23039341 1867192 Positive_regulation MAP2K6 PIK3R1 23125836 952466 Positive_regulation MAP2K6 PIK3R1 23977080 2838295 Positive_regulation MAP2K6 PIK3R1 23986655 931114 Positive_regulation MAP2K6 PIK3R1 24036604 2184843 Positive_regulation MAP2K6 PIK3R1 24041012 746125 Positive_regulation MAP2K6 PIK3R1 24272818 2185606 Positive_regulation MAP2K6 PIK3R1 24312008 868011 Positive_regulation MAP2K6 PIK3R1 24577313 1124441 Positive_regulation MAP2K6 PIK3R1 24795729 912610 Positive_regulation MAP2K6 PIK3R1 24810962 2190428 Positive_regulation MAP2K6 PIK3R1 24939055 1508148 Positive_regulation MAP2K6 PKN1 19317917 1005831 Positive_regulation MAP2K6 PKN1 19317917 1005893 Positive_regulation MAP2K6 PKN1 21494665 2513483 Positive_regulation MAP2K6 PNKD 23542180 218410 Positive_regulation MAP2K6 POLDIP2 22069624 3182814 Positive_regulation MAP2K6 POT1 25118589 1944739 Positive_regulation MAP2K6 POU5F1 19777066 2427212 Positive_regulation MAP2K6 PPP2CA 19897477 1167246 Positive_regulation MAP2K6 PPP2CA 24937142 851380 Positive_regulation MAP2K6 PPP2R1A 19897477 1167247 Positive_regulation MAP2K6 PPP2R1A 24937142 851381 Positive_regulation MAP2K6 PPP2R2B 19897477 1167248 Positive_regulation MAP2K6 PPP2R2B 24937142 851382 Positive_regulation MAP2K6 PPP3CA 14623863 1301045 Positive_regulation MAP2K6 PPP3CB 14623863 1301046 Positive_regulation MAP2K6 PPP3CC 14623863 1301047 Positive_regulation MAP2K6 PRKACB 19664265 1897335 Positive_regulation MAP2K6 PRKACB 21510868 1861608 Positive_regulation MAP2K6 PRKACB 22022509 2563446 Positive_regulation MAP2K6 PRKACG 19664265 1897336 Positive_regulation MAP2K6 PRKACG 21510868 1861609 Positive_regulation MAP2K6 PRKACG 22022509 2563447 Positive_regulation MAP2K6 PRKAR1A 19664265 1897337 Positive_regulation MAP2K6 PRKAR1A 21510868 1861610 Positive_regulation MAP2K6 PRKAR1A 22022509 2563448 Positive_regulation MAP2K6 PRKAR1B 19664265 1897338 Positive_regulation MAP2K6 PRKAR1B 21510868 1861611 Positive_regulation MAP2K6 PRKAR1B 22022509 2563449 Positive_regulation MAP2K6 PRKAR2A 19664265 1897339 Positive_regulation MAP2K6 PRKAR2A 21510868 1861612 Positive_regulation MAP2K6 PRKAR2A 22022509 2563450 Positive_regulation MAP2K6 PRKAR2B 19664265 1897340 Positive_regulation MAP2K6 PRKAR2B 21510868 1861613 Positive_regulation MAP2K6 PRKAR2B 22022509 2563451 Positive_regulation MAP2K6 PRKCA 21525937 551838 Positive_regulation MAP2K6 PTBP1 21544193 2517157 Positive_regulation MAP2K6 PTBP2 21544193 2517154 Positive_regulation MAP2K6 PTGFR 19812696 2428024 Positive_regulation MAP2K6 PTPN11 25535838 762920 Positive_regulation MAP2K6 PTPN13 19734941 2126779 Positive_regulation MAP2K6 PTPN13 PMC4261712 1049463 Positive_regulation MAP2K6 PVR 16216929 1324761 Positive_regulation MAP2K6 RAC1 19015320 1361339 Positive_regulation MAP2K6 RAC1 19015320 1361729 Positive_regulation MAP2K6 RAC1 23006971 2181086 Positive_regulation MAP2K6 RAC1 23734197 2799573 Positive_regulation MAP2K6 RAC1 24086766 2855752 Positive_regulation MAP2K6 RAC2 23006971 2181087 Positive_regulation MAP2K6 RAC3 23006971 2181088 Positive_regulation MAP2K6 RAD50 25118589 1944742 Positive_regulation MAP2K6 RAF1 16846534 459988 Positive_regulation MAP2K6 RAF1 17922568 2289521 Positive_regulation MAP2K6 RAF1 18282094 3040898 Positive_regulation MAP2K6 RAF1 19018286 2401001 Positive_regulation MAP2K6 RAF1 20054438 175953 Positive_regulation MAP2K6 RAF1 22035226 528014 Positive_regulation MAP2K6 RAF1 22073013 1729130 Positive_regulation MAP2K6 RAF1 22384111 2605925 Positive_regulation MAP2K6 RAF1 22463874 1506301 Positive_regulation MAP2K6 RAF1 23085539 2181446 Positive_regulation MAP2K6 RAF1 23094148 1689761 Positive_regulation MAP2K6 RAF1 23118896 2711966 Positive_regulation MAP2K6 RAF1 23365487 1751370 Positive_regulation MAP2K6 RAF1 23843700 2249832 Positive_regulation MAP2K6 RAF1 23970928 822305 Positive_regulation MAP2K6 RAF1 25411776 3028827 Positive_regulation MAP2K6 RAF1 7722458 1592037 Positive_regulation MAP2K6 RALA 20003375 254837 Positive_regulation MAP2K6 RASA1 24937142 851420 Positive_regulation MAP2K6 REG3A 22563495 2626905 Positive_regulation MAP2K6 REG3A 22563495 2626922 Positive_regulation MAP2K6 RELA 16491824 1710833 Positive_regulation MAP2K6 RIT1 24469055 2154654 Positive_regulation MAP2K6 RIT1 24469055 2154655 Positive_regulation MAP2K6 RIT1 24469055 2154678 Positive_regulation MAP2K6 RNF19A 20300552 1672035 Positive_regulation MAP2K6 ROCK1 19077254 385162 Positive_regulation MAP2K6 RPTOR 23624914 2152133 Positive_regulation MAP2K6 RRM1 23922955 2827809 Positive_regulation MAP2K6 S100A8 24133496 909269 Positive_regulation MAP2K6 SCRIB 23359326 2744936 Positive_regulation MAP2K6 SH2B1 20868529 1647849 Positive_regulation MAP2K6 SH2B1 20868529 1647850 Positive_regulation MAP2K6 SHC1 18404483 3087952 Positive_regulation MAP2K6 SIX1 22765220 471684 Positive_regulation MAP2K6 SIX1 22765220 471716 Positive_regulation MAP2K6 SIX1 22765220 471735 Positive_regulation MAP2K6 SKIV2L 23818902 2119913 Positive_regulation MAP2K6 SLC22A3 21383698 2138593 Positive_regulation MAP2K6 SMAD3 17474984 656580 Positive_regulation MAP2K6 SMAD7 24090133 537588 Positive_regulation MAP2K6 SOAT1 24312008 868003 Positive_regulation MAP2K6 SOS1 18521338 3127498 Positive_regulation MAP2K6 SOS2 18521338 3127499 Positive_regulation MAP2K6 SOX9 23840193 878953 Positive_regulation MAP2K6 SPRY1 24970815 2194195 Positive_regulation MAP2K6 SPRY2 24970815 2194196 Positive_regulation MAP2K6 SPRY3 24970815 2194197 Positive_regulation MAP2K6 SPRY4 24970815 2194198 Positive_regulation MAP2K6 SRC 12876277 1294758 Positive_regulation MAP2K6 SRC 18404483 3088160 Positive_regulation MAP2K6 SRC 18460189 2232708 Positive_regulation MAP2K6 SRC 18573916 1353086 Positive_regulation MAP2K6 SRC 21049052 2480617 Positive_regulation MAP2K6 SRC 21401944 304798 Positive_regulation MAP2K6 SRC 25478577 201733 Positive_regulation MAP2K6 STAT3 21909139 2142526 Positive_regulation MAP2K6 STAT3 23251519 2728743 Positive_regulation MAP2K6 STAT6 25071444 869836 Positive_regulation MAP2K6 STS 24096434 93490 Positive_regulation MAP2K6 SUB1 19930650 526260 Positive_regulation MAP2K6 SUB1 19930650 526291 Positive_regulation MAP2K6 SUB1 19930650 526309 Positive_regulation MAP2K6 SULT1A3 25071492 861197 Positive_regulation MAP2K6 SWAP70 23555004 2774185 Positive_regulation MAP2K6 TAB1 22496778 2617450 Positive_regulation MAP2K6 TAB1 22566960 900557 Positive_regulation MAP2K6 TAT 20380698 3118891 Positive_regulation MAP2K6 TAT 24742347 3124347 Positive_regulation MAP2K6 TCF12 24852887 3157679 Positive_regulation MAP2K6 TCF15 24852887 3157680 Positive_regulation MAP2K6 TCF19 24852887 3157681 Positive_regulation MAP2K6 TCF20 24852887 3157682 Positive_regulation MAP2K6 TCF21 24852887 3157683 Positive_regulation MAP2K6 TCF23 24852887 3157687 Positive_regulation MAP2K6 TCF24 24852887 3157689 Positive_regulation MAP2K6 TCF25 24852887 3157688 Positive_regulation MAP2K6 TCF3 24852887 3157684 Positive_regulation MAP2K6 TCF4 24852887 3157685 Positive_regulation MAP2K6 TCF7 24852887 3157686 Positive_regulation MAP2K6 TERF1 25118589 1944736 Positive_regulation MAP2K6 TERF2 25118589 1944737 Positive_regulation MAP2K6 TERF2IP 25118589 1944740 Positive_regulation MAP2K6 TES 20802223 2253170 Positive_regulation MAP2K6 TGFA 23752269 1905040 Positive_regulation MAP2K6 TINF2 25118589 1944738 Positive_regulation MAP2K6 TLR1 22577336 3128534 Positive_regulation MAP2K6 TLR10 22577336 3128543 Positive_regulation MAP2K6 TLR2 22577336 3128535 Positive_regulation MAP2K6 TLR3 22577336 3128536 Positive_regulation MAP2K6 TLR4 20827308 979286 Positive_regulation MAP2K6 TLR4 22577336 3128537 Positive_regulation MAP2K6 TLR5 22577336 3128538 Positive_regulation MAP2K6 TLR6 22577336 3128544 Positive_regulation MAP2K6 TLR7 20832340 1040229 Positive_regulation MAP2K6 TLR7 22577336 3128540 Positive_regulation MAP2K6 TLR8 22577336 3128541 Positive_regulation MAP2K6 TLR9 22577336 3128542 Positive_regulation MAP2K6 TNF 19808894 711235 Positive_regulation MAP2K6 TNF 19808894 711236 Positive_regulation MAP2K6 TNF 19808894 711398 Positive_regulation MAP2K6 TNF 20624904 1377611 Positive_regulation MAP2K6 TNFRSF8 22852078 1689360 Positive_regulation MAP2K6 TNFSF11 21861861 123798 Positive_regulation MAP2K6 TNFSF11 22577336 3128539 Positive_regulation MAP2K6 TP53 20190820 2129204 Positive_regulation MAP2K6 TP53 20190820 2129205 Positive_regulation MAP2K6 TP53 20190820 2129206 Positive_regulation MAP2K6 TP53 21422497 29163 Positive_regulation MAP2K6 TRAF6 12186654 994890 Positive_regulation MAP2K6 TYR 18460189 2232709 Positive_regulation MAP2K6 USP15 23105109 1205473 Positive_regulation MAP2K6 VCP 24667437 2938754 Positive_regulation MAP2K6 VEGFA 11238463 1267780 Positive_regulation MAP2K6 VEGFA 20222950 255582 Positive_regulation MAP2K6 VEGFA 21998580 3053750 Positive_regulation MAP2K6 VEGFA 22294553 777970 Positive_regulation MAP2K6 VEGFA 23028860 2693473 Positive_regulation MAP2K6 VEGFA 25212428 1685527 Positive_regulation MAP2K6 VEGFC 21693010 468394 Positive_regulation MAP2K6 VEGFC 22745786 2656465 Positive_regulation MAP2K6 VGF 19388902 590563 Positive_regulation MAP2K6 VIMP 24667437 2938756 Positive_regulation MAP2K6 WDR61 8642312 1596837 Positive_regulation MAP2K6 WWOX 23459853 942397 Positive_regulation MAP2K6 YWHAB 17958888 1242719 Positive_regulation MAP2K6 YWHAB 18332218 1349897 Positive_regulation MAP2K6 YWHAB 19018286 2401000 Positive_regulation MAP2K6 YWHAB 20054438 175952 Positive_regulation MAP2K6 YWHAB 22529971 2620793 Positive_regulation MAP2K6 YWHAB 23970928 822304 Positive_regulation MAP2K6 YWHAB 24918056 853910 Positive_regulation MAP2K6 YWHAB 25074438 1702400 Positive_regulation MAP2K7 CCND1 22833568 1806102 Positive_regulation MAP2K7 CD14 20827308 979289 Positive_regulation MAP2K7 CTGF 16774692 106032 Positive_regulation MAP2K7 CTGF 24637722 2934855 Positive_regulation MAP2K7 CTGF 24637722 2934862 Positive_regulation MAP2K7 EPHB2 10477763 1249350 Positive_regulation MAP2K7 EPHB2 11309409 1269506 Positive_regulation MAP2K7 EPHB2 17474984 656581 Positive_regulation MAP2K7 EPHB2 18332218 1349902 Positive_regulation MAP2K7 EPHB2 19682393 1646619 Positive_regulation MAP2K7 EPHB2 19707375 175668 Positive_regulation MAP2K7 EPHB2 21860657 813165 Positive_regulation MAP2K7 EPHB2 22077956 3091395 Positive_regulation MAP2K7 EPHB2 22753777 477721 Positive_regulation MAP2K7 EPHB2 23617883 1867955 Positive_regulation MAP2K7 EPHB2 23782265 151714 Positive_regulation MAP2K7 EPHB2 24416349 2907660 Positive_regulation MAP2K7 EPHB2 24516336 2249845 Positive_regulation MAP2K7 EPHB2 24608898 2932862 Positive_regulation MAP2K7 EPHB2 25013907 2988114 Positive_regulation MAP2K7 EPHB2 25126479 212380 Positive_regulation MAP2K7 EPHB2 25514788 3034683 Positive_regulation MAP2K7 EPHB2 8996240 1599795 Positive_regulation MAP2K7 EPHB2 8996240 1599824 Positive_regulation MAP2K7 FAS 9362518 1464834 Positive_regulation MAP2K7 HBEGF 22873932 533013 Positive_regulation MAP2K7 HBEGF 22873932 533052 Positive_regulation MAP2K7 HBEGF 25342939 685351 Positive_regulation MAP2K7 IFI27 21114830 403454 Positive_regulation MAP2K7 MAP2K6 20550965 158597 Positive_regulation MAP2K7 MUC16 17391532 3108147 Positive_regulation MAP2K7 TLR7 20832340 1040230 Positive_regulation MAP2K7 TLR7 22577336 3128551 Positive_regulation MAP2K7 TNF 19808894 711241 Positive_regulation MAP2K7 TNF 19808894 711242 Positive_regulation MAP2K7 TNF 19808894 711400 Positive_regulation MAP2K7 TNF 20624904 1377613 Positive_regulation MAP3K1 AXIN2 11739413 1277191 Positive_regulation MAP3K11 SLC38A3 20637111 1647219 Positive_regulation MAP3K11 TNF 19918265 609842 Positive_regulation MAP3K11 TNF 19918265 609843 Positive_regulation MAP3K11 TNF 19918265 609844 Positive_regulation MAP3K11 TNF 19918265 609845 Positive_regulation MAP3K11 TNF 19918265 609846 Positive_regulation MAP3K11 TNF 19918265 609847 Positive_regulation MAP3K11 TNF 19918265 609870 Positive_regulation MAP3K11 TNF 19918265 609871 Positive_regulation MAP3K11 TNF 19918265 609872 Positive_regulation MAP3K11 TNF 19918265 609885 Positive_regulation MAP3K11 TNF 19918265 609892 Positive_regulation MAP3K11 TNF 19918265 609901 Positive_regulation MAP3K11 TNF 19918265 609902 Positive_regulation MAP3K11 TNF 19918265 609903 Positive_regulation MAP3K11 TNF 19918265 609910 Positive_regulation MAP3K11 TNF 19918265 609911 Positive_regulation MAP3K11 TNF 19918265 609924 Positive_regulation MAP3K11 TNF 19918265 609925 Positive_regulation MAP3K11 TNF 19918265 609931 Positive_regulation MAP3K11 TNF 19918265 609932 Positive_regulation MAP3K11 TNF 19918265 609933 Positive_regulation MAP3K11 TNF 19918265 609935 Positive_regulation MAP3K12 TNF 24949464 192753 Positive_regulation MAP3K5 CTGF 23227240 2725722 Positive_regulation MAP3K5 CTGF 23227240 2725730 Positive_regulation MAP3K5 CTGF 23227240 2725737 Positive_regulation MAP3K5 FAS 15123887 1212191 Positive_regulation MAP3K5 FAS 22719792 814724 Positive_regulation MAP3K5 TFPI2 16953237 427985 Positive_regulation MAP3K5 TFPI2 22654913 1068288 Positive_regulation MAP3K5 TNF 19389260 525275 Positive_regulation MAP3K5 TNF 22111877 334716 Positive_regulation MAP3K5 TNF 22151968 238314 Positive_regulation MAP3K5 TNF 22719792 814723 Positive_regulation MAP3K5 TNF 23696882 2795777 Positive_regulation MAP3K5 TNF 24284943 1939665 Positive_regulation MAP3K5 TNF 24723994 2228584 Positive_regulation MAP3K5 TNFSF10 23696862 2795592 Positive_regulation MAP3K7 STK39 21488180 3232618 Positive_regulation MAP3K7 TLR7 19234607 2406034 Positive_regulation MAP3K7 TLR7 19234607 2406055 Positive_regulation MAP3K7 TLR7 19234607 2406081 Positive_regulation MAP3K7 TLR7 19234607 2406082 Positive_regulation MAP3K7 TLR7 23527104 2769421 Positive_regulation MAP3K7 TLR7 23527104 2769422 Positive_regulation MAP3K7 TLR7 23760366 2211857 Positive_regulation MAP3K7 TLR7 23760366 2211858 Positive_regulation MAP3K7 TLR7 24498425 2919829 Positive_regulation MAP3K7 TLR7 24498425 2919862 Positive_regulation MAP3K7 TLR7 24586659 2926044 Positive_regulation MAP3K7 TNF 20585657 2454216 Positive_regulation MAP3K7 TNF 22069560 3181843 Positive_regulation MAP3K7 TNF 22313861 3160931 Positive_regulation MAP3K7 TNF 23300658 2734298 Positive_regulation MAP3K7 TNF 23300658 2734302 Positive_regulation MAP3K7 TNF 23331383 1675497 Positive_regulation MAP3K7 TNF 23472066 2763775 Positive_regulation MAP3K7 TNF 23844119 2819461 Positive_regulation MAP3K7 TNF 23844119 2819471 Positive_regulation MAP3K7 TNF 23844119 2819479 Positive_regulation MAP3K7 TNF 24386633 186131 Positive_regulation MAP3K7 TNF 24487321 1959834 Positive_regulation MAP3K7 TNF 24535827 1416514 Positive_regulation MAP3K7 TNF 24535827 1416515 Positive_regulation MAP3K7 TNF 24535827 1416605 Positive_regulation MAP3K7 TNF 25221541 881116 Positive_regulation MAP3K7 TNFSF10 19421137 2125073 Positive_regulation MAP3K7 TNFSF10 19421137 2125076 Positive_regulation MAP3K7 TNFSF10 19421137 2125079 Positive_regulation MAP3K7 TNFSF10 19421137 2125088 Positive_regulation MAP3K7 TNFSF10 20062539 2436819 Positive_regulation MAP3K8 EPHB2 19667062 1555613 Positive_regulation MAP3K8 EPHB2 19667062 1555614 Positive_regulation MAP3K8 EPHB2 19667062 1555615 Positive_regulation MAP3K8 EPHB2 19667062 1555687 Positive_regulation MAP3K8 EPHB2 21267413 2495403 Positive_regulation MAP3K8 NEDD9 24980047 1576863 Positive_regulation MAP3K8 TLR7 23527104 2769442 Positive_regulation MAP3K8 TLR7 23527104 2769443 Positive_regulation MAP3K8 TNF 19808894 711259 Positive_regulation MAP3K8 TNF 19808894 711260 Positive_regulation MAP3K8 TNF 19808894 711261 Positive_regulation MAP3K8 TNF 19808894 711438 Positive_regulation MAP3K8 TNF 24642963 2935454 Positive_regulation MAP4K2 TNF 17925029 320864 Positive_regulation MAP4K4 TNF 18671879 323967 Positive_regulation MAP4K4 TNF 22816003 2371454 Positive_regulation MAP4K4 TNF 22816003 2371468 Positive_regulation MAP4K4 TNF 22816003 2371469 Positive_regulation MAP4K4 TNF 24244164 3064991 Positive_regulation MAPK1 ALOX5 22363611 2601199 Positive_regulation MAPK1 ALOX5 25025775 2989409 Positive_regulation MAPK1 ANGPT1 22187650 1145443 Positive_regulation MAPK1 ANGPT1 24013716 2842147 Positive_regulation MAPK1 ANGPT1 25329960 3017087 Positive_regulation MAPK1 ARSA 20339548 2444458 Positive_regulation MAPK1 ARSA 20339548 2444486 Positive_regulation MAPK1 ARSA 20640495 511700 Positive_regulation MAPK1 CAPN8 24416390 2908307 Positive_regulation MAPK1 CCND1 22220184 1155991 Positive_regulation MAPK1 CCND1 25047753 240881 Positive_regulation MAPK1 CD14 20011115 3045928 Positive_regulation MAPK1 CD14 20150966 1213530 Positive_regulation MAPK1 CD14 21387014 2506181 Positive_regulation MAPK1 CD14 24376813 2902211 Positive_regulation MAPK1 CEACAM6 22905257 2675870 Positive_regulation MAPK1 CHI3L1 22211103 1058700 Positive_regulation MAPK1 CHI3L1 23755018 961362 Positive_regulation MAPK1 CHI3L1 23972995 608987 Positive_regulation MAPK1 CHI3L1 23972995 608988 Positive_regulation MAPK1 CHI3L1 24729664 1758066 Positive_regulation MAPK1 CTGF 21760921 2535984 Positive_regulation MAPK1 CTGF 21760921 2535985 Positive_regulation MAPK1 CTGF 21760921 2535994 Positive_regulation MAPK1 CTGF 21760921 2536000 Positive_regulation MAPK1 CTGF 21760921 2536010 Positive_regulation MAPK1 CTGF 21760921 2536013 Positive_regulation MAPK1 CTGF 22135505 3128243 Positive_regulation MAPK1 CTGF 22918238 541769 Positive_regulation MAPK1 CTGF 23383241 2749635 Positive_regulation MAPK1 CTGF 23946690 1716062 Positive_regulation MAPK1 CTGF 25514242 1135697 Positive_regulation MAPK1 CYP24A1 22577546 1139586 Positive_regulation MAPK1 EDN2 12369712 1077797 Positive_regulation MAPK1 EDN2 24695532 2948221 Positive_regulation MAPK1 EPHB2 11783444 2001207 Positive_regulation MAPK1 EPHB2 18578886 356864 Positive_regulation MAPK1 EPHB2 19047466 1361957 Positive_regulation MAPK1 EPHB2 19047466 1361958 Positive_regulation MAPK1 EPHB2 19047466 1361959 Positive_regulation MAPK1 EPHB2 19047466 1362093 Positive_regulation MAPK1 EPHB2 19047466 1362094 Positive_regulation MAPK1 EPHB2 19047466 1362132 Positive_regulation MAPK1 EPHB2 19107595 1027480 Positive_regulation MAPK1 EPHB2 19272185 1227045 Positive_regulation MAPK1 EPHB2 19357636 1902950 Positive_regulation MAPK1 EPHB2 20100173 212585 Positive_regulation MAPK1 EPHB2 20559500 1090225 Positive_regulation MAPK1 EPHB2 21488184 3232780 Positive_regulation MAPK1 EPHB2 21488184 3232781 Positive_regulation MAPK1 EPHB2 21876711 813181 Positive_regulation MAPK1 EPHB2 22294469 135331 Positive_regulation MAPK1 EPHB2 22507553 1661693 Positive_regulation MAPK1 EPHB2 22675451 2648325 Positive_regulation MAPK1 EPHB2 22719861 2653313 Positive_regulation MAPK1 EPHB2 22723883 2655008 Positive_regulation MAPK1 EPHB2 22741533 381917 Positive_regulation MAPK1 EPHB2 22951718 1631187 Positive_regulation MAPK1 EPHB2 23383241 2749636 Positive_regulation MAPK1 EPHB2 23388501 1920505 Positive_regulation MAPK1 EPHB2 23738323 181917 Positive_regulation MAPK1 EPHB2 23826208 2811460 Positive_regulation MAPK1 EPHB2 24058777 1705456 Positive_regulation MAPK1 EPHB2 24098984 1726339 Positive_regulation MAPK1 EPHB2 24823621 1624662 Positive_regulation MAPK1 EPHB2 24885161 396501 Positive_regulation MAPK1 EPHB2 24978597 2985602 Positive_regulation MAPK1 EPHB2 25299961 174469 Positive_regulation MAPK1 F2R 15940829 2001638 Positive_regulation MAPK1 F2R 21378407 2175453 Positive_regulation MAPK1 F2R 21760880 2535479 Positive_regulation MAPK1 F2R 21760880 2535741 Positive_regulation MAPK1 F2R 21845431 3158094 Positive_regulation MAPK1 F2R 24215724 538270 Positive_regulation MAPK1 F2R 24278684 3150063 Positive_regulation MAPK1 F2R 24743392 2955201 Positive_regulation MAPK1 F2R 24743392 2955333 Positive_regulation MAPK1 F2R 24743392 2955407 Positive_regulation MAPK1 F2R 24860547 880667 Positive_regulation MAPK1 FAS 11259103 418436 Positive_regulation MAPK1 FAS 14970175 1531118 Positive_regulation MAPK1 FAS 19487421 1555052 Positive_regulation MAPK1 FAS 19564926 1055584 Positive_regulation MAPK1 FAS 20573240 1856424 Positive_regulation MAPK1 FAS 20573240 1856450 Positive_regulation MAPK1 FAS 21477291 527139 Positive_regulation MAPK1 FAS 21975294 552670 Positive_regulation MAPK1 FAS 21975294 552671 Positive_regulation MAPK1 FAS 21975294 552672 Positive_regulation MAPK1 FAS 21975294 552673 Positive_regulation MAPK1 FAS 21975294 552674 Positive_regulation MAPK1 FAS 21975294 552675 Positive_regulation MAPK1 FAS 21975294 552786 Positive_regulation MAPK1 FAS 21975294 552787 Positive_regulation MAPK1 FAS 21975294 552788 Positive_regulation MAPK1 FAS 21975294 552880 Positive_regulation MAPK1 FAS 21975294 552881 Positive_regulation MAPK1 FAS 21975294 552882 Positive_regulation MAPK1 FAS 21975294 553009 Positive_regulation MAPK1 FAS 23029562 2698766 Positive_regulation MAPK1 FAS 23029562 2698787 Positive_regulation MAPK1 FAS 23852022 1108456 Positive_regulation MAPK1 FAS 25196936 1730921 Positive_regulation MAPK1 FAS 9362518 1464803 Positive_regulation MAPK1 FAS 9396757 1465251 Positive_regulation MAPK1 FBXO32 22082477 682628 Positive_regulation MAPK1 FBXO32 23046544 3161233 Positive_regulation MAPK1 FOXO1 20375467 26949 Positive_regulation MAPK1 GLP1R 23536825 2773057 Positive_regulation MAPK1 GPR115 22570668 634960 Positive_regulation MAPK1 GPR132 22570668 634949 Positive_regulation MAPK1 GPR87 22570668 635029 Positive_regulation MAPK1 HBEGF 15817123 1844594 Positive_regulation MAPK1 HBEGF 15817123 1844681 Positive_regulation MAPK1 HBEGF 22259731 1146097 Positive_regulation MAPK1 HBEGF 22792252 2661655 Positive_regulation MAPK1 HBEGF 22984591 2689347 Positive_regulation MAPK1 HBEGF PMC3760629 1606198 Positive_regulation MAPK1 IFI27 11560992 1520872 Positive_regulation MAPK1 ITGB2 21206905 2491102 Positive_regulation MAPK1 ITGB2 21850266 2542742 Positive_regulation MAPK1 ITGB2 23508943 906506 Positive_regulation MAPK1 LBP 20150966 1213531 Positive_regulation MAPK1 MAP2K6 10330402 1246228 Positive_regulation MAPK1 MAP2K6 10477763 1249229 Positive_regulation MAPK1 MAP2K6 10737387 416956 Positive_regulation MAPK1 MAP2K6 11259103 418438 Positive_regulation MAPK1 MAP2K6 12117640 791046 Positive_regulation MAPK1 MAP2K6 14981092 1306425 Positive_regulation MAPK1 MAP2K6 15353558 1533371 Positive_regulation MAPK1 MAP2K6 15946381 3105047 Positive_regulation MAPK1 MAP2K6 15946381 3105065 Positive_regulation MAPK1 MAP2K6 16048647 3105296 Positive_regulation MAPK1 MAP2K6 16103225 1323174 Positive_regulation MAPK1 MAP2K6 17425806 225612 Positive_regulation MAPK1 MAP2K6 17525795 2013993 Positive_regulation MAPK1 MAP2K6 17576777 1546421 Positive_regulation MAPK1 MAP2K6 18949068 2208033 Positive_regulation MAPK1 MAP2K6 18955270 810916 Positive_regulation MAPK1 MAP2K6 19159010 1055154 Positive_regulation MAPK1 MAP2K6 19159010 1055372 Positive_regulation MAPK1 MAP2K6 19426550 282511 Positive_regulation MAPK1 MAP2K6 19668516 649411 Positive_regulation MAPK1 MAP2K6 20221403 2442583 Positive_regulation MAPK1 MAP2K6 20463961 2449777 Positive_regulation MAPK1 MAP2K6 20802223 2253135 Positive_regulation MAPK1 MAP2K6 20955562 120535 Positive_regulation MAPK1 MAP2K6 20955562 120645 Positive_regulation MAPK1 MAP2K6 21345249 121617 Positive_regulation MAPK1 MAP2K6 21699731 1862555 Positive_regulation MAPK1 MAP2K6 22028883 2564894 Positive_regulation MAPK1 MAP2K6 22069624 3182819 Positive_regulation MAPK1 MAP2K6 22159586 600541 Positive_regulation MAPK1 MAP2K6 22245064 613543 Positive_regulation MAPK1 MAP2K6 22315658 1702860 Positive_regulation MAPK1 MAP2K6 22359624 2598490 Positive_regulation MAPK1 MAP2K6 22415879 721992 Positive_regulation MAPK1 MAP2K6 22415879 722322 Positive_regulation MAPK1 MAP2K6 22529896 2620544 Positive_regulation MAPK1 MAP2K6 22606284 2642699 Positive_regulation MAPK1 MAP2K6 22649371 874811 Positive_regulation MAPK1 MAP2K6 22740774 490677 Positive_regulation MAPK1 MAP2K6 22870983 288764 Positive_regulation MAPK1 MAP2K6 22870983 288903 Positive_regulation MAPK1 MAP2K6 22870983 289012 Positive_regulation MAPK1 MAP2K6 23115639 2711447 Positive_regulation MAPK1 MAP2K6 23166686 2718462 Positive_regulation MAPK1 MAP2K6 23535559 1721121 Positive_regulation MAPK1 MAP2K6 23772401 852320 Positive_regulation MAPK1 MAP2K6 23936348 2830094 Positive_regulation MAPK1 MAP2K6 24566153 1124312 Positive_regulation MAPK1 MAP2K6 24586913 2928388 Positive_regulation MAPK1 MAP2K6 24717932 1023928 Positive_regulation MAPK1 MAP2K6 24792484 2960438 Positive_regulation MAPK1 MAP2K6 24853429 576314 Positive_regulation MAPK1 MAP2K6 25364728 861769 Positive_regulation MAPK1 MAP2K6 25479605 3032510 Positive_regulation MAPK1 MAP2K6 9700154 1469427 Positive_regulation MAPK1 MIP 17233909 351814 Positive_regulation MAPK1 MIP 19781090 1625735 Positive_regulation MAPK1 MIP 21977329 1082344 Positive_regulation MAPK1 MMP28 18778487 384786 Positive_regulation MAPK1 MMP28 20667128 1857672 Positive_regulation MAPK1 MMP28 23688423 313810 Positive_regulation MAPK1 MMP28 23688423 314255 Positive_regulation MAPK1 MMP28 23878609 821728 Positive_regulation MAPK1 MMP28 25520932 202988 Positive_regulation MAPK1 MMP7 20667128 1857687 Positive_regulation MAPK1 MMP7 23688423 313825 Positive_regulation MAPK1 MMP7 23688423 314271 Positive_regulation MAPK1 MMP7 23878609 821744 Positive_regulation MAPK1 MMP7 25520932 203003 Positive_regulation MAPK1 MUC16 17029558 2302985 Positive_regulation MAPK1 MUC16 23694968 3135904 Positive_regulation MAPK1 NES 21682918 1862508 Positive_regulation MAPK1 NES 22419908 951388 Positive_regulation MAPK1 NGFR 22880054 2673859 Positive_regulation MAPK1 NGFR 25243118 199115 Positive_regulation MAPK1 NR2F1 24906407 273645 Positive_regulation MAPK1 OXTR 22190926 1072833 Positive_regulation MAPK1 PLAU 23724131 2799115 Positive_regulation MAPK1 PLAU 23724131 2799382 Positive_regulation MAPK1 PTGER2 25327961 216571 Positive_regulation MAPK1 RCAN1 19124655 1553349 Positive_regulation MAPK1 RCAN1 19124655 1553469 Positive_regulation MAPK1 RGS2 24743392 2955334 Positive_regulation MAPK1 S100A7 19159013 2404524 Positive_regulation MAPK1 S100B 22276098 2589815 Positive_regulation MAPK1 S100B 23259641 1665761 Positive_regulation MAPK1 S100B 23259641 1665775 Positive_regulation MAPK1 S100B 23259641 1665789 Positive_regulation MAPK1 SCGB3A1 22289642 335842 Positive_regulation MAPK1 SLC6A2 18509476 2389895 Positive_regulation MAPK1 SPHK1 16847102 1331294 Positive_regulation MAPK1 SPHK1 20498849 2451130 Positive_regulation MAPK1 SPHK1 20498849 2451165 Positive_regulation MAPK1 SPHK1 25245676 2201749 Positive_regulation MAPK1 SPHK1 25245676 2201750 Positive_regulation MAPK1 TLR7 17371930 1544900 Positive_regulation MAPK1 TLR7 19043549 3042343 Positive_regulation MAPK1 TLR7 19043549 3042487 Positive_regulation MAPK1 TLR7 19371402 733911 Positive_regulation MAPK1 TLR7 19685283 495352 Positive_regulation MAPK1 TLR7 20832340 1040231 Positive_regulation MAPK1 TLR7 21633096 1992377 Positive_regulation MAPK1 TLR7 21743791 1028405 Positive_regulation MAPK1 TLR7 21943110 2231307 Positive_regulation MAPK1 TLR7 22110382 1058283 Positive_regulation MAPK1 TLR7 22216226 2584788 Positive_regulation MAPK1 TLR7 22829768 3058349 Positive_regulation MAPK1 TLR7 23202320 3184631 Positive_regulation MAPK1 TLR7 23305364 693940 Positive_regulation MAPK1 TLR7 23521892 3215278 Positive_regulation MAPK1 TLR7 23527104 2769459 Positive_regulation MAPK1 TLR7 23527104 2769488 Positive_regulation MAPK1 TLR7 23603814 1962809 Positive_regulation MAPK1 TLR7 23760366 2211872 Positive_regulation MAPK1 TLR7 23840534 2814947 Positive_regulation MAPK1 TLR7 24489933 2916781 Positive_regulation MAPK1 TLR7 24603716 2932021 Positive_regulation MAPK1 TLR7 24772440 189676 Positive_regulation MAPK1 TLR7 24800851 2960994 Positive_regulation MAPK1 TLR7 25177436 646936 Positive_regulation MAPK1 TNF 11015442 1517380 Positive_regulation MAPK1 TNF 11015442 1517418 Positive_regulation MAPK1 TNF 11015442 1517431 Positive_regulation MAPK1 TNF 11015442 1517444 Positive_regulation MAPK1 TNF 14613529 3095421 Positive_regulation MAPK1 TNF 15157285 277597 Positive_regulation MAPK1 TNF 15642133 102173 Positive_regulation MAPK1 TNF 15781582 1535123 Positive_regulation MAPK1 TNF 15841081 425526 Positive_regulation MAPK1 TNF 15841081 425527 Positive_regulation MAPK1 TNF 15841081 425867 Positive_regulation MAPK1 TNF 16100442 1634487 Positive_regulation MAPK1 TNF 16100442 1634627 Positive_regulation MAPK1 TNF 16207331 104238 Positive_regulation MAPK1 TNF 16207331 104271 Positive_regulation MAPK1 TNF 16207331 104272 Positive_regulation MAPK1 TNF 16207331 104311 Positive_regulation MAPK1 TNF 16207331 104312 Positive_regulation MAPK1 TNF 16207331 104350 Positive_regulation MAPK1 TNF 16207342 104514 Positive_regulation MAPK1 TNF 16207342 104566 Positive_regulation MAPK1 TNF 17283208 1544254 Positive_regulation MAPK1 TNF 17342245 810726 Positive_regulation MAPK1 TNF 18096615 2032340 Positive_regulation MAPK1 TNF 18404427 3087181 Positive_regulation MAPK1 TNF 18410682 110437 Positive_regulation MAPK1 TNF 19343193 1746541 Positive_regulation MAPK1 TNF 19442267 1696266 Positive_regulation MAPK1 TNF 19707336 175491 Positive_regulation MAPK1 TNF 19723340 1227344 Positive_regulation MAPK1 TNF 19723340 1227359 Positive_regulation MAPK1 TNF 19723340 1227373 Positive_regulation MAPK1 TNF 20157567 26206 Positive_regulation MAPK1 TNF 20157567 26444 Positive_regulation MAPK1 TNF 20308428 1373857 Positive_regulation MAPK1 TNF 20418897 9884 Positive_regulation MAPK1 TNF 20529221 34773 Positive_regulation MAPK1 TNF 20615213 119624 Positive_regulation MAPK1 TNF 20644550 10418 Positive_regulation MAPK1 TNF 20844314 27771 Positive_regulation MAPK1 TNF 20844314 28234 Positive_regulation MAPK1 TNF 20871620 11944 Positive_regulation MAPK1 TNF 21386087 718526 Positive_regulation MAPK1 TNF 21423395 955223 Positive_regulation MAPK1 TNF 21485745 734902 Positive_regulation MAPK1 TNF 21572963 2520295 Positive_regulation MAPK1 TNF 21837268 1082179 Positive_regulation MAPK1 TNF 21867555 1659574 Positive_regulation MAPK1 TNF 21871121 1659625 Positive_regulation MAPK1 TNF 22082477 682545 Positive_regulation MAPK1 TNF 22194685 3055226 Positive_regulation MAPK1 TNF 22802702 1714253 Positive_regulation MAPK1 TNF 22802702 1714266 Positive_regulation MAPK1 TNF 22802702 1714299 Positive_regulation MAPK1 TNF 22988345 1750556 Positive_regulation MAPK1 TNF 23028407 2219753 Positive_regulation MAPK1 TNF 23071583 2703144 Positive_regulation MAPK1 TNF 23071583 2703165 Positive_regulation MAPK1 TNF 23152905 2716803 Positive_regulation MAPK1 TNF 23190711 1665173 Positive_regulation MAPK1 TNF 23282009 1665850 Positive_regulation MAPK1 TNF 23326019 1751329 Positive_regulation MAPK1 TNF 23331383 1675499 Positive_regulation MAPK1 TNF 23533994 180654 Positive_regulation MAPK1 TNF 23626383 1046745 Positive_regulation MAPK1 TNF 23671702 2792489 Positive_regulation MAPK1 TNF 23671702 2792508 Positive_regulation MAPK1 TNF 23688423 314250 Positive_regulation MAPK1 TNF 23690670 1752150 Positive_regulation MAPK1 TNF 23755184 2801834 Positive_regulation MAPK1 TNF 23784308 606111 Positive_regulation MAPK1 TNF 23784308 606126 Positive_regulation MAPK1 TNF 23967215 2834984 Positive_regulation MAPK1 TNF 23977119 2838446 Positive_regulation MAPK1 TNF 24008729 565158 Positive_regulation MAPK1 TNF 24008729 565506 Positive_regulation MAPK1 TNF 24013271 2842022 Positive_regulation MAPK1 TNF 24024042 2003207 Positive_regulation MAPK1 TNF 24039713 2844610 Positive_regulation MAPK1 TNF 24039713 2844646 Positive_regulation MAPK1 TNF 24069158 2851368 Positive_regulation MAPK1 TNF 24069158 2851538 Positive_regulation MAPK1 TNF 24069158 2851539 Positive_regulation MAPK1 TNF 24086560 2854623 Positive_regulation MAPK1 TNF 24101950 2227318 Positive_regulation MAPK1 TNF 24244348 2879492 Positive_regulation MAPK1 TNF 24266983 240385 Positive_regulation MAPK1 TNF 24285913 737676 Positive_regulation MAPK1 TNF 24307884 3155523 Positive_regulation MAPK1 TNF 24377382 3225642 Positive_regulation MAPK1 TNF 24423080 538870 Positive_regulation MAPK1 TNF 24460683 240485 Positive_regulation MAPK1 TNF 24487321 1959835 Positive_regulation MAPK1 TNF 24489443 1757402 Positive_regulation MAPK1 TNF 24502696 1233038 Positive_regulation MAPK1 TNF 24502696 1233061 Positive_regulation MAPK1 TNF 24502696 1233108 Positive_regulation MAPK1 TNF 24502696 1233109 Positive_regulation MAPK1 TNF 24502696 1233153 Positive_regulation MAPK1 TNF 24502696 1233154 Positive_regulation MAPK1 TNF 24502696 1233217 Positive_regulation MAPK1 TNF 24502696 1233258 Positive_regulation MAPK1 TNF 24502696 1233291 Positive_regulation MAPK1 TNF 24587316 2929409 Positive_regulation MAPK1 TNF 24614867 2933180 Positive_regulation MAPK1 TNF 24616552 1757555 Positive_regulation MAPK1 TNF 24707477 188308 Positive_regulation MAPK1 TNF 24707477 188432 Positive_regulation MAPK1 TNF 24707477 188462 Positive_regulation MAPK1 TNF 24758719 1483146 Positive_regulation MAPK1 TNF 24773466 34202 Positive_regulation MAPK1 TNF 24821138 2969094 Positive_regulation MAPK1 TNF 24886088 347465 Positive_regulation MAPK1 TNF 25090227 2995080 Positive_regulation MAPK1 TNF 25110549 2229785 Positive_regulation MAPK1 TNF 25114952 3156811 Positive_regulation MAPK1 TNF 25114952 3156827 Positive_regulation MAPK1 TNF 25152756 826687 Positive_regulation MAPK1 TNF 25196285 3224109 Positive_regulation MAPK1 TNF 25206704 2005722 Positive_regulation MAPK1 TNF 25435878 1074929 Positive_regulation MAPK1 TNF 7525608 1436374 Positive_regulation MAPK1 TNF 7530764 1589995 Positive_regulation MAPK1 TNF 8562342 445244 Positive_regulation MAPK1 TNF 8666946 1597665 Positive_regulation MAPK1 TNFSF10 22462553 1230457 Positive_regulation MAPK1 TNFSF10 22719861 2653312 Positive_regulation MAPK1 TNFSF10 24143232 2868024 Positive_regulation MAPK10 ALOX5 22363611 2601200 Positive_regulation MAPK10 ALOX5 25025775 2989410 Positive_regulation MAPK10 ANGPT1 24013716 2842148 Positive_regulation MAPK10 ANGPT1 25329960 3017090 Positive_regulation MAPK10 ARSA 20339548 2444459 Positive_regulation MAPK10 ARSA 20339548 2444487 Positive_regulation MAPK10 CAPN8 24416390 2908321 Positive_regulation MAPK10 CCND1 22220184 1155992 Positive_regulation MAPK10 CCND1 25047753 240889 Positive_regulation MAPK10 CD14 20011115 3045929 Positive_regulation MAPK10 CD14 21387014 2506182 Positive_regulation MAPK10 CD14 24376813 2902214 Positive_regulation MAPK10 CHI3L1 23755018 961365 Positive_regulation MAPK10 CHI3L1 23972995 608989 Positive_regulation MAPK10 CHI3L1 23972995 608990 Positive_regulation MAPK10 CHI3L1 24729664 1758067 Positive_regulation MAPK10 CTGF 22135505 3128244 Positive_regulation MAPK10 CTGF 22918238 541770 Positive_regulation MAPK10 CTGF 23383241 2749637 Positive_regulation MAPK10 CTGF 23946690 1716063 Positive_regulation MAPK10 CYP24A1 22577546 1139587 Positive_regulation MAPK10 EDN2 12369712 1077800 Positive_regulation MAPK10 EDN2 24695532 2948224 Positive_regulation MAPK10 EPHB2 11783444 2001208 Positive_regulation MAPK10 EPHB2 18578886 356865 Positive_regulation MAPK10 EPHB2 19047466 1361960 Positive_regulation MAPK10 EPHB2 19047466 1361961 Positive_regulation MAPK10 EPHB2 19047466 1361962 Positive_regulation MAPK10 EPHB2 19047466 1362095 Positive_regulation MAPK10 EPHB2 19047466 1362096 Positive_regulation MAPK10 EPHB2 19047466 1362133 Positive_regulation MAPK10 EPHB2 19107595 1027482 Positive_regulation MAPK10 EPHB2 19357636 1902952 Positive_regulation MAPK10 EPHB2 20100173 212586 Positive_regulation MAPK10 EPHB2 21488184 3232782 Positive_regulation MAPK10 EPHB2 21488184 3232783 Positive_regulation MAPK10 EPHB2 21876711 813182 Positive_regulation MAPK10 EPHB2 22294469 135332 Positive_regulation MAPK10 EPHB2 22507553 1661699 Positive_regulation MAPK10 EPHB2 22675451 2648328 Positive_regulation MAPK10 EPHB2 22719861 2653315 Positive_regulation MAPK10 EPHB2 22723883 2655009 Positive_regulation MAPK10 EPHB2 22741533 381919 Positive_regulation MAPK10 EPHB2 22951718 1631188 Positive_regulation MAPK10 EPHB2 23383241 2749638 Positive_regulation MAPK10 EPHB2 23388501 1920506 Positive_regulation MAPK10 EPHB2 23738323 181919 Positive_regulation MAPK10 EPHB2 23826208 2811461 Positive_regulation MAPK10 EPHB2 24098984 1726340 Positive_regulation MAPK10 EPHB2 24823621 1624663 Positive_regulation MAPK10 EPHB2 24885161 396502 Positive_regulation MAPK10 EPHB2 24978597 2985603 Positive_regulation MAPK10 EPHB2 25299961 174470 Positive_regulation MAPK10 F2R 21378407 2175454 Positive_regulation MAPK10 F2R 21760880 2535485 Positive_regulation MAPK10 F2R 21760880 2535747 Positive_regulation MAPK10 F2R 21845431 3158095 Positive_regulation MAPK10 F2R 24215724 538271 Positive_regulation MAPK10 F2R 24278684 3150064 Positive_regulation MAPK10 F2R 24743392 2955204 Positive_regulation MAPK10 F2R 24743392 2955336 Positive_regulation MAPK10 F2R 24743392 2955408 Positive_regulation MAPK10 F2R 24860547 880670 Positive_regulation MAPK10 FAS 11259103 418439 Positive_regulation MAPK10 FAS 14970175 1531119 Positive_regulation MAPK10 FAS 19487421 1555054 Positive_regulation MAPK10 FAS 19564926 1055585 Positive_regulation MAPK10 FAS 20573240 1856425 Positive_regulation MAPK10 FAS 20573240 1856451 Positive_regulation MAPK10 FAS 21477291 527140 Positive_regulation MAPK10 FAS 21975294 552676 Positive_regulation MAPK10 FAS 21975294 552677 Positive_regulation MAPK10 FAS 21975294 552678 Positive_regulation MAPK10 FAS 21975294 552679 Positive_regulation MAPK10 FAS 21975294 552680 Positive_regulation MAPK10 FAS 21975294 552681 Positive_regulation MAPK10 FAS 21975294 552789 Positive_regulation MAPK10 FAS 21975294 552790 Positive_regulation MAPK10 FAS 21975294 552791 Positive_regulation MAPK10 FAS 21975294 552886 Positive_regulation MAPK10 FAS 21975294 552887 Positive_regulation MAPK10 FAS 21975294 552888 Positive_regulation MAPK10 FAS 21975294 553023 Positive_regulation MAPK10 FAS 23029562 2698767 Positive_regulation MAPK10 FAS 23029562 2698788 Positive_regulation MAPK10 FAS 23852022 1108457 Positive_regulation MAPK10 FAS 25196936 1730923 Positive_regulation MAPK10 FAS 9362518 1464805 Positive_regulation MAPK10 FBXO32 22082477 682631 Positive_regulation MAPK10 FBXO32 23046544 3161234 Positive_regulation MAPK10 FOXO1 20375467 26953 Positive_regulation MAPK10 GLP1R 23536825 2773058 Positive_regulation MAPK10 GPR115 22570668 635053 Positive_regulation MAPK10 GPR132 22570668 635042 Positive_regulation MAPK10 GPR87 22570668 635122 Positive_regulation MAPK10 HBEGF 15817123 1844597 Positive_regulation MAPK10 HBEGF 15817123 1844683 Positive_regulation MAPK10 HBEGF 22259731 1146098 Positive_regulation MAPK10 HBEGF 22792252 2661656 Positive_regulation MAPK10 HBEGF PMC3760629 1606199 Positive_regulation MAPK10 IFI27 11560992 1520874 Positive_regulation MAPK10 ITGB2 21206905 2491104 Positive_regulation MAPK10 ITGB2 23508943 906508 Positive_regulation MAPK10 MAP2K6 10330402 1246230 Positive_regulation MAPK10 MAP2K6 10737387 416963 Positive_regulation MAPK10 MAP2K6 11259103 418441 Positive_regulation MAPK10 MAP2K6 12117640 791053 Positive_regulation MAPK10 MAP2K6 14981092 1306433 Positive_regulation MAPK10 MAP2K6 16048647 3105303 Positive_regulation MAPK10 MAP2K6 17525795 2013994 Positive_regulation MAPK10 MAP2K6 17576777 1546428 Positive_regulation MAPK10 MAP2K6 18955270 810929 Positive_regulation MAPK10 MAP2K6 19159010 1055155 Positive_regulation MAPK10 MAP2K6 19159010 1055373 Positive_regulation MAPK10 MAP2K6 19426550 282518 Positive_regulation MAPK10 MAP2K6 20221403 2442585 Positive_regulation MAPK10 MAP2K6 20463961 2449779 Positive_regulation MAPK10 MAP2K6 20802223 2253136 Positive_regulation MAPK10 MAP2K6 20955562 120539 Positive_regulation MAPK10 MAP2K6 20955562 120647 Positive_regulation MAPK10 MAP2K6 21345249 121624 Positive_regulation MAPK10 MAP2K6 22028883 2564901 Positive_regulation MAPK10 MAP2K6 22159586 600548 Positive_regulation MAPK10 MAP2K6 22245064 613550 Positive_regulation MAPK10 MAP2K6 22359624 2598498 Positive_regulation MAPK10 MAP2K6 22415879 721997 Positive_regulation MAPK10 MAP2K6 22415879 722327 Positive_regulation MAPK10 MAP2K6 22529896 2620551 Positive_regulation MAPK10 MAP2K6 22740774 490684 Positive_regulation MAPK10 MAP2K6 22870983 288765 Positive_regulation MAPK10 MAP2K6 22870983 288904 Positive_regulation MAPK10 MAP2K6 22870983 289013 Positive_regulation MAPK10 MAP2K6 23115639 2711449 Positive_regulation MAPK10 MAP2K6 23166686 2718469 Positive_regulation MAPK10 MAP2K6 23535559 1721130 Positive_regulation MAPK10 MAP2K6 23772401 852359 Positive_regulation MAPK10 MAP2K6 23936348 2830101 Positive_regulation MAPK10 MAP2K6 24566153 1124319 Positive_regulation MAPK10 MAP2K6 24792484 2960445 Positive_regulation MAPK10 MAP2K6 25364728 861771 Positive_regulation MAPK10 MAP2K6 25479605 3032517 Positive_regulation MAPK10 MAP2K6 9700154 1469434 Positive_regulation MAPK10 MIP 19781090 1625736 Positive_regulation MAPK10 MIP 21977329 1082345 Positive_regulation MAPK10 MMP28 18778487 384787 Positive_regulation MAPK10 MMP28 23688423 313832 Positive_regulation MAPK10 MMP28 23688423 314279 Positive_regulation MAPK10 MMP28 23878609 821751 Positive_regulation MAPK10 MMP28 25520932 203010 Positive_regulation MAPK10 MMP7 23688423 313847 Positive_regulation MAPK10 MMP7 23688423 314295 Positive_regulation MAPK10 MMP7 23878609 821767 Positive_regulation MAPK10 MMP7 25520932 203025 Positive_regulation MAPK10 MUC16 17029558 2303001 Positive_regulation MAPK10 MUC16 23694968 3135907 Positive_regulation MAPK10 NGFR 22880054 2673861 Positive_regulation MAPK10 NR2F1 24906407 273646 Positive_regulation MAPK10 OXTR 22190926 1072834 Positive_regulation MAPK10 PLAU 23724131 2799117 Positive_regulation MAPK10 PLAU 23724131 2799383 Positive_regulation MAPK10 PTGER2 25327961 216572 Positive_regulation MAPK10 RCAN1 19124655 1553350 Positive_regulation MAPK10 RCAN1 19124655 1553470 Positive_regulation MAPK10 RGS2 24743392 2955337 Positive_regulation MAPK10 S100B 22276098 2589817 Positive_regulation MAPK10 S100B 23259641 1665762 Positive_regulation MAPK10 S100B 23259641 1665776 Positive_regulation MAPK10 S100B 23259641 1665790 Positive_regulation MAPK10 SCGB3A1 22289642 335843 Positive_regulation MAPK10 SLC6A2 18509476 2389896 Positive_regulation MAPK10 SPHK1 16847102 1331296 Positive_regulation MAPK10 SPHK1 20498849 2451131 Positive_regulation MAPK10 SPHK1 20498849 2451166 Positive_regulation MAPK10 TLR7 19043549 3042353 Positive_regulation MAPK10 TLR7 19043549 3042497 Positive_regulation MAPK10 TLR7 19371402 733921 Positive_regulation MAPK10 TLR7 19685283 495362 Positive_regulation MAPK10 TLR7 20832340 1040232 Positive_regulation MAPK10 TLR7 21633096 1992387 Positive_regulation MAPK10 TLR7 21743791 1028415 Positive_regulation MAPK10 TLR7 21943110 2231317 Positive_regulation MAPK10 TLR7 22110382 1058293 Positive_regulation MAPK10 TLR7 22216226 2584798 Positive_regulation MAPK10 TLR7 22829768 3058359 Positive_regulation MAPK10 TLR7 23202320 3184642 Positive_regulation MAPK10 TLR7 23305364 693950 Positive_regulation MAPK10 TLR7 23521892 3215288 Positive_regulation MAPK10 TLR7 23603814 1962821 Positive_regulation MAPK10 TLR7 23760366 2211882 Positive_regulation MAPK10 TLR7 23840534 2814957 Positive_regulation MAPK10 TLR7 24489933 2916791 Positive_regulation MAPK10 TLR7 24603716 2932031 Positive_regulation MAPK10 TLR7 24772440 189686 Positive_regulation MAPK10 TLR7 24800851 2961004 Positive_regulation MAPK10 TLR7 25177436 646946 Positive_regulation MAPK10 TNF 11015442 1517382 Positive_regulation MAPK10 TNF 11015442 1517419 Positive_regulation MAPK10 TNF 11015442 1517432 Positive_regulation MAPK10 TNF 11015442 1517445 Positive_regulation MAPK10 TNF 14613529 3095422 Positive_regulation MAPK10 TNF 15157285 277598 Positive_regulation MAPK10 TNF 15642133 102175 Positive_regulation MAPK10 TNF 15781582 1535124 Positive_regulation MAPK10 TNF 15841081 425528 Positive_regulation MAPK10 TNF 15841081 425529 Positive_regulation MAPK10 TNF 15841081 425868 Positive_regulation MAPK10 TNF 16100442 1634499 Positive_regulation MAPK10 TNF 16100442 1634628 Positive_regulation MAPK10 TNF 16207331 104239 Positive_regulation MAPK10 TNF 16207331 104273 Positive_regulation MAPK10 TNF 16207331 104274 Positive_regulation MAPK10 TNF 16207331 104314 Positive_regulation MAPK10 TNF 16207331 104315 Positive_regulation MAPK10 TNF 16207331 104351 Positive_regulation MAPK10 TNF 16207342 104515 Positive_regulation MAPK10 TNF 16207342 104567 Positive_regulation MAPK10 TNF 17283208 1544255 Positive_regulation MAPK10 TNF 17342245 810727 Positive_regulation MAPK10 TNF 18096615 2032342 Positive_regulation MAPK10 TNF 18404427 3087182 Positive_regulation MAPK10 TNF 18410682 110438 Positive_regulation MAPK10 TNF 19343193 1746542 Positive_regulation MAPK10 TNF 19442267 1696267 Positive_regulation MAPK10 TNF 19707336 175493 Positive_regulation MAPK10 TNF 19723340 1227345 Positive_regulation MAPK10 TNF 19723340 1227360 Positive_regulation MAPK10 TNF 19723340 1227374 Positive_regulation MAPK10 TNF 20157567 26209 Positive_regulation MAPK10 TNF 20157567 26445 Positive_regulation MAPK10 TNF 20308428 1373858 Positive_regulation MAPK10 TNF 20418897 9885 Positive_regulation MAPK10 TNF 20529221 34774 Positive_regulation MAPK10 TNF 20615213 119627 Positive_regulation MAPK10 TNF 20644550 10419 Positive_regulation MAPK10 TNF 20844314 27772 Positive_regulation MAPK10 TNF 20844314 28235 Positive_regulation MAPK10 TNF 20871620 11945 Positive_regulation MAPK10 TNF 21386087 718528 Positive_regulation MAPK10 TNF 21423395 955225 Positive_regulation MAPK10 TNF 21485745 734904 Positive_regulation MAPK10 TNF 21572963 2520296 Positive_regulation MAPK10 TNF 21837268 1082180 Positive_regulation MAPK10 TNF 21867555 1659575 Positive_regulation MAPK10 TNF 21871121 1659626 Positive_regulation MAPK10 TNF 22082477 682547 Positive_regulation MAPK10 TNF 22194685 3055227 Positive_regulation MAPK10 TNF 22802702 1714254 Positive_regulation MAPK10 TNF 22802702 1714267 Positive_regulation MAPK10 TNF 22802702 1714300 Positive_regulation MAPK10 TNF 22988345 1750557 Positive_regulation MAPK10 TNF 23028407 2219757 Positive_regulation MAPK10 TNF 23071583 2703145 Positive_regulation MAPK10 TNF 23071583 2703166 Positive_regulation MAPK10 TNF 23152905 2716804 Positive_regulation MAPK10 TNF 23190711 1665174 Positive_regulation MAPK10 TNF 23282009 1665851 Positive_regulation MAPK10 TNF 23326019 1751330 Positive_regulation MAPK10 TNF 23331383 1675501 Positive_regulation MAPK10 TNF 23533994 180655 Positive_regulation MAPK10 TNF 23626383 1046747 Positive_regulation MAPK10 TNF 23671702 2792490 Positive_regulation MAPK10 TNF 23688423 314274 Positive_regulation MAPK10 TNF 23690670 1752152 Positive_regulation MAPK10 TNF 23755184 2801835 Positive_regulation MAPK10 TNF 23784308 606112 Positive_regulation MAPK10 TNF 23784308 606128 Positive_regulation MAPK10 TNF 23967215 2834987 Positive_regulation MAPK10 TNF 23977119 2838447 Positive_regulation MAPK10 TNF 24008729 565159 Positive_regulation MAPK10 TNF 24008729 565507 Positive_regulation MAPK10 TNF 24024042 2003208 Positive_regulation MAPK10 TNF 24069158 2851373 Positive_regulation MAPK10 TNF 24069158 2851540 Positive_regulation MAPK10 TNF 24069158 2851541 Positive_regulation MAPK10 TNF 24086560 2854624 Positive_regulation MAPK10 TNF 24101950 2227319 Positive_regulation MAPK10 TNF 24244348 2879493 Positive_regulation MAPK10 TNF 24266983 240386 Positive_regulation MAPK10 TNF 24285913 737677 Positive_regulation MAPK10 TNF 24307884 3155524 Positive_regulation MAPK10 TNF 24377382 3225643 Positive_regulation MAPK10 TNF 24423080 538871 Positive_regulation MAPK10 TNF 24460683 240486 Positive_regulation MAPK10 TNF 24487321 1959836 Positive_regulation MAPK10 TNF 24489443 1757403 Positive_regulation MAPK10 TNF 24502696 1233039 Positive_regulation MAPK10 TNF 24502696 1233062 Positive_regulation MAPK10 TNF 24502696 1233110 Positive_regulation MAPK10 TNF 24502696 1233111 Positive_regulation MAPK10 TNF 24502696 1233155 Positive_regulation MAPK10 TNF 24502696 1233156 Positive_regulation MAPK10 TNF 24502696 1233218 Positive_regulation MAPK10 TNF 24502696 1233260 Positive_regulation MAPK10 TNF 24502696 1233292 Positive_regulation MAPK10 TNF 24587316 2929410 Positive_regulation MAPK10 TNF 24614867 2933181 Positive_regulation MAPK10 TNF 24616552 1757556 Positive_regulation MAPK10 TNF 24707477 188313 Positive_regulation MAPK10 TNF 24707477 188433 Positive_regulation MAPK10 TNF 24707477 188463 Positive_regulation MAPK10 TNF 24758719 1483147 Positive_regulation MAPK10 TNF 24773466 34203 Positive_regulation MAPK10 TNF 24821138 2969095 Positive_regulation MAPK10 TNF 24886088 347466 Positive_regulation MAPK10 TNF 25090227 2995081 Positive_regulation MAPK10 TNF 25110549 2229786 Positive_regulation MAPK10 TNF 25114952 3156812 Positive_regulation MAPK10 TNF 25114952 3156828 Positive_regulation MAPK10 TNF 25152756 826689 Positive_regulation MAPK10 TNF 25196285 3224110 Positive_regulation MAPK10 TNF 25206704 2005723 Positive_regulation MAPK10 TNF 25435878 1074930 Positive_regulation MAPK10 TNF 7525608 1436375 Positive_regulation MAPK10 TNF 7530764 1589996 Positive_regulation MAPK10 TNF 8562342 445245 Positive_regulation MAPK10 TNF 8666946 1597666 Positive_regulation MAPK10 TNFSF10 22462553 1230458 Positive_regulation MAPK10 TNFSF10 22719861 2653314 Positive_regulation MAPK11 ALOX5 22363611 2601201 Positive_regulation MAPK11 ALOX5 25025775 2989411 Positive_regulation MAPK11 ANGPT1 24013716 2842149 Positive_regulation MAPK11 ANGPT1 25329960 3017093 Positive_regulation MAPK11 ARSA 20339548 2444460 Positive_regulation MAPK11 ARSA 20339548 2444488 Positive_regulation MAPK11 CAPN8 24416390 2908335 Positive_regulation MAPK11 CCND1 22220184 1155993 Positive_regulation MAPK11 CCND1 25047753 240897 Positive_regulation MAPK11 CD14 20011115 3045930 Positive_regulation MAPK11 CD14 21387014 2506183 Positive_regulation MAPK11 CD14 24376813 2902217 Positive_regulation MAPK11 CHI3L1 23755018 961368 Positive_regulation MAPK11 CHI3L1 23972995 608991 Positive_regulation MAPK11 CHI3L1 23972995 608992 Positive_regulation MAPK11 CHI3L1 24729664 1758068 Positive_regulation MAPK11 CTGF 22135505 3128245 Positive_regulation MAPK11 CTGF 22918238 541771 Positive_regulation MAPK11 CTGF 23383241 2749639 Positive_regulation MAPK11 CTGF 23946690 1716064 Positive_regulation MAPK11 CYP24A1 22577546 1139588 Positive_regulation MAPK11 EDN2 12369712 1077803 Positive_regulation MAPK11 EDN2 24695532 2948227 Positive_regulation MAPK11 EPHB2 11783444 2001209 Positive_regulation MAPK11 EPHB2 18578886 356866 Positive_regulation MAPK11 EPHB2 19047466 1361963 Positive_regulation MAPK11 EPHB2 19047466 1361964 Positive_regulation MAPK11 EPHB2 19047466 1361965 Positive_regulation MAPK11 EPHB2 19047466 1362097 Positive_regulation MAPK11 EPHB2 19047466 1362098 Positive_regulation MAPK11 EPHB2 19047466 1362134 Positive_regulation MAPK11 EPHB2 19107595 1027484 Positive_regulation MAPK11 EPHB2 19357636 1902954 Positive_regulation MAPK11 EPHB2 20100173 212587 Positive_regulation MAPK11 EPHB2 21488184 3232784 Positive_regulation MAPK11 EPHB2 21488184 3232785 Positive_regulation MAPK11 EPHB2 21876711 813183 Positive_regulation MAPK11 EPHB2 22294469 135333 Positive_regulation MAPK11 EPHB2 22507553 1661705 Positive_regulation MAPK11 EPHB2 22675451 2648331 Positive_regulation MAPK11 EPHB2 22719861 2653317 Positive_regulation MAPK11 EPHB2 22723883 2655010 Positive_regulation MAPK11 EPHB2 22741533 381921 Positive_regulation MAPK11 EPHB2 22951718 1631189 Positive_regulation MAPK11 EPHB2 23383241 2749640 Positive_regulation MAPK11 EPHB2 23388501 1920507 Positive_regulation MAPK11 EPHB2 23738323 181921 Positive_regulation MAPK11 EPHB2 23826208 2811462 Positive_regulation MAPK11 EPHB2 24098984 1726341 Positive_regulation MAPK11 EPHB2 24823621 1624664 Positive_regulation MAPK11 EPHB2 24885161 396503 Positive_regulation MAPK11 EPHB2 24978597 2985604 Positive_regulation MAPK11 EPHB2 25299961 174471 Positive_regulation MAPK11 F2R 21378407 2175455 Positive_regulation MAPK11 F2R 21760880 2535491 Positive_regulation MAPK11 F2R 21760880 2535753 Positive_regulation MAPK11 F2R 21845431 3158096 Positive_regulation MAPK11 F2R 24215724 538272 Positive_regulation MAPK11 F2R 24278684 3150065 Positive_regulation MAPK11 F2R 24743392 2955207 Positive_regulation MAPK11 F2R 24743392 2955339 Positive_regulation MAPK11 F2R 24743392 2955409 Positive_regulation MAPK11 F2R 24860547 880673 Positive_regulation MAPK11 FAS 11259103 418442 Positive_regulation MAPK11 FAS 14970175 1531120 Positive_regulation MAPK11 FAS 19487421 1555056 Positive_regulation MAPK11 FAS 19564926 1055586 Positive_regulation MAPK11 FAS 20573240 1856426 Positive_regulation MAPK11 FAS 20573240 1856452 Positive_regulation MAPK11 FAS 21477291 527141 Positive_regulation MAPK11 FAS 21975294 552682 Positive_regulation MAPK11 FAS 21975294 552683 Positive_regulation MAPK11 FAS 21975294 552684 Positive_regulation MAPK11 FAS 21975294 552685 Positive_regulation MAPK11 FAS 21975294 552686 Positive_regulation MAPK11 FAS 21975294 552687 Positive_regulation MAPK11 FAS 21975294 552792 Positive_regulation MAPK11 FAS 21975294 552793 Positive_regulation MAPK11 FAS 21975294 552794 Positive_regulation MAPK11 FAS 21975294 552892 Positive_regulation MAPK11 FAS 21975294 552893 Positive_regulation MAPK11 FAS 21975294 552894 Positive_regulation MAPK11 FAS 21975294 553037 Positive_regulation MAPK11 FAS 23029562 2698768 Positive_regulation MAPK11 FAS 23029562 2698789 Positive_regulation MAPK11 FAS 23852022 1108458 Positive_regulation MAPK11 FAS 25196936 1730925 Positive_regulation MAPK11 FAS 9362518 1464807 Positive_regulation MAPK11 FBXO32 22082477 682634 Positive_regulation MAPK11 FBXO32 23046544 3161235 Positive_regulation MAPK11 FOXO1 20375467 26957 Positive_regulation MAPK11 GLP1R 23536825 2773059 Positive_regulation MAPK11 GPR115 22570668 635146 Positive_regulation MAPK11 GPR132 22570668 635135 Positive_regulation MAPK11 GPR87 22570668 635215 Positive_regulation MAPK11 HBEGF 15817123 1844600 Positive_regulation MAPK11 HBEGF 15817123 1844685 Positive_regulation MAPK11 HBEGF 22259731 1146099 Positive_regulation MAPK11 HBEGF 22792252 2661657 Positive_regulation MAPK11 HBEGF PMC3760629 1606200 Positive_regulation MAPK11 IFI27 11560992 1520876 Positive_regulation MAPK11 ITGB2 21206905 2491106 Positive_regulation MAPK11 ITGB2 23508943 906510 Positive_regulation MAPK11 MAP2K6 10330402 1246232 Positive_regulation MAPK11 MAP2K6 10737387 416970 Positive_regulation MAPK11 MAP2K6 11259103 418444 Positive_regulation MAPK11 MAP2K6 12117640 791060 Positive_regulation MAPK11 MAP2K6 14981092 1306441 Positive_regulation MAPK11 MAP2K6 16048647 3105310 Positive_regulation MAPK11 MAP2K6 17525795 2013995 Positive_regulation MAPK11 MAP2K6 17576777 1546435 Positive_regulation MAPK11 MAP2K6 18955270 810942 Positive_regulation MAPK11 MAP2K6 19159010 1055156 Positive_regulation MAPK11 MAP2K6 19159010 1055374 Positive_regulation MAPK11 MAP2K6 19426550 282525 Positive_regulation MAPK11 MAP2K6 20221403 2442587 Positive_regulation MAPK11 MAP2K6 20463961 2449781 Positive_regulation MAPK11 MAP2K6 20802223 2253137 Positive_regulation MAPK11 MAP2K6 20955562 120543 Positive_regulation MAPK11 MAP2K6 20955562 120649 Positive_regulation MAPK11 MAP2K6 21345249 121631 Positive_regulation MAPK11 MAP2K6 22028883 2564908 Positive_regulation MAPK11 MAP2K6 22159586 600555 Positive_regulation MAPK11 MAP2K6 22245064 613557 Positive_regulation MAPK11 MAP2K6 22359624 2598506 Positive_regulation MAPK11 MAP2K6 22415879 722002 Positive_regulation MAPK11 MAP2K6 22415879 722332 Positive_regulation MAPK11 MAP2K6 22529896 2620558 Positive_regulation MAPK11 MAP2K6 22740774 490691 Positive_regulation MAPK11 MAP2K6 22870983 288766 Positive_regulation MAPK11 MAP2K6 22870983 288905 Positive_regulation MAPK11 MAP2K6 22870983 289014 Positive_regulation MAPK11 MAP2K6 23115639 2711451 Positive_regulation MAPK11 MAP2K6 23166686 2718476 Positive_regulation MAPK11 MAP2K6 23535559 1721139 Positive_regulation MAPK11 MAP2K6 23772401 852398 Positive_regulation MAPK11 MAP2K6 23936348 2830108 Positive_regulation MAPK11 MAP2K6 24566153 1124326 Positive_regulation MAPK11 MAP2K6 24792484 2960452 Positive_regulation MAPK11 MAP2K6 25364728 861773 Positive_regulation MAPK11 MAP2K6 25479605 3032524 Positive_regulation MAPK11 MAP2K6 9700154 1469441 Positive_regulation MAPK11 MIP 19781090 1625737 Positive_regulation MAPK11 MIP 21977329 1082346 Positive_regulation MAPK11 MMP28 18778487 384788 Positive_regulation MAPK11 MMP28 23688423 313854 Positive_regulation MAPK11 MMP28 23688423 314303 Positive_regulation MAPK11 MMP28 23878609 821774 Positive_regulation MAPK11 MMP28 25520932 203032 Positive_regulation MAPK11 MMP7 23688423 313869 Positive_regulation MAPK11 MMP7 23688423 314319 Positive_regulation MAPK11 MMP7 23878609 821790 Positive_regulation MAPK11 MMP7 25520932 203047 Positive_regulation MAPK11 MUC16 17029558 2303017 Positive_regulation MAPK11 MUC16 23694968 3135910 Positive_regulation MAPK11 NGFR 22880054 2673863 Positive_regulation MAPK11 NR2F1 24906407 273647 Positive_regulation MAPK11 OXTR 22190926 1072835 Positive_regulation MAPK11 PLAU 23724131 2799119 Positive_regulation MAPK11 PLAU 23724131 2799384 Positive_regulation MAPK11 PTGER2 25327961 216573 Positive_regulation MAPK11 RCAN1 19124655 1553351 Positive_regulation MAPK11 RCAN1 19124655 1553471 Positive_regulation MAPK11 RGS2 24743392 2955340 Positive_regulation MAPK11 S100B 22276098 2589819 Positive_regulation MAPK11 S100B 23259641 1665763 Positive_regulation MAPK11 S100B 23259641 1665777 Positive_regulation MAPK11 S100B 23259641 1665791 Positive_regulation MAPK11 SCGB3A1 22289642 335844 Positive_regulation MAPK11 SLC6A2 18509476 2389897 Positive_regulation MAPK11 SPHK1 16847102 1331298 Positive_regulation MAPK11 SPHK1 20498849 2451132 Positive_regulation MAPK11 SPHK1 20498849 2451167 Positive_regulation MAPK11 TLR7 19043549 3042363 Positive_regulation MAPK11 TLR7 19043549 3042507 Positive_regulation MAPK11 TLR7 19371402 733931 Positive_regulation MAPK11 TLR7 19685283 495372 Positive_regulation MAPK11 TLR7 20832340 1040233 Positive_regulation MAPK11 TLR7 21633096 1992397 Positive_regulation MAPK11 TLR7 21743791 1028425 Positive_regulation MAPK11 TLR7 21943110 2231327 Positive_regulation MAPK11 TLR7 22110382 1058303 Positive_regulation MAPK11 TLR7 22216226 2584808 Positive_regulation MAPK11 TLR7 22829768 3058369 Positive_regulation MAPK11 TLR7 23202320 3184653 Positive_regulation MAPK11 TLR7 23305364 693960 Positive_regulation MAPK11 TLR7 23521892 3215298 Positive_regulation MAPK11 TLR7 23603814 1962833 Positive_regulation MAPK11 TLR7 23760366 2211892 Positive_regulation MAPK11 TLR7 23840534 2814967 Positive_regulation MAPK11 TLR7 24489933 2916801 Positive_regulation MAPK11 TLR7 24603716 2932041 Positive_regulation MAPK11 TLR7 24772440 189696 Positive_regulation MAPK11 TLR7 24800851 2961014 Positive_regulation MAPK11 TLR7 25177436 646956 Positive_regulation MAPK11 TNF 11015442 1517384 Positive_regulation MAPK11 TNF 11015442 1517420 Positive_regulation MAPK11 TNF 11015442 1517433 Positive_regulation MAPK11 TNF 11015442 1517446 Positive_regulation MAPK11 TNF 14613529 3095423 Positive_regulation MAPK11 TNF 15157285 277599 Positive_regulation MAPK11 TNF 15642133 102177 Positive_regulation MAPK11 TNF 15781582 1535125 Positive_regulation MAPK11 TNF 15841081 425530 Positive_regulation MAPK11 TNF 15841081 425531 Positive_regulation MAPK11 TNF 15841081 425869 Positive_regulation MAPK11 TNF 16100442 1634511 Positive_regulation MAPK11 TNF 16100442 1634629 Positive_regulation MAPK11 TNF 16207331 104240 Positive_regulation MAPK11 TNF 16207331 104275 Positive_regulation MAPK11 TNF 16207331 104276 Positive_regulation MAPK11 TNF 16207331 104317 Positive_regulation MAPK11 TNF 16207331 104318 Positive_regulation MAPK11 TNF 16207331 104352 Positive_regulation MAPK11 TNF 16207342 104516 Positive_regulation MAPK11 TNF 16207342 104568 Positive_regulation MAPK11 TNF 17283208 1544256 Positive_regulation MAPK11 TNF 17342245 810728 Positive_regulation MAPK11 TNF 18096615 2032344 Positive_regulation MAPK11 TNF 18404427 3087183 Positive_regulation MAPK11 TNF 18410682 110439 Positive_regulation MAPK11 TNF 19343193 1746543 Positive_regulation MAPK11 TNF 19442267 1696268 Positive_regulation MAPK11 TNF 19707336 175495 Positive_regulation MAPK11 TNF 19723340 1227346 Positive_regulation MAPK11 TNF 19723340 1227361 Positive_regulation MAPK11 TNF 19723340 1227375 Positive_regulation MAPK11 TNF 20157567 26212 Positive_regulation MAPK11 TNF 20157567 26446 Positive_regulation MAPK11 TNF 20308428 1373859 Positive_regulation MAPK11 TNF 20418897 9886 Positive_regulation MAPK11 TNF 20529221 34775 Positive_regulation MAPK11 TNF 20615213 119630 Positive_regulation MAPK11 TNF 20644550 10420 Positive_regulation MAPK11 TNF 20844314 27773 Positive_regulation MAPK11 TNF 20844314 28236 Positive_regulation MAPK11 TNF 20871620 11946 Positive_regulation MAPK11 TNF 21386087 718530 Positive_regulation MAPK11 TNF 21423395 955227 Positive_regulation MAPK11 TNF 21485745 734906 Positive_regulation MAPK11 TNF 21572963 2520297 Positive_regulation MAPK11 TNF 21837268 1082181 Positive_regulation MAPK11 TNF 21867555 1659576 Positive_regulation MAPK11 TNF 21871121 1659627 Positive_regulation MAPK11 TNF 22082477 682549 Positive_regulation MAPK11 TNF 22194685 3055228 Positive_regulation MAPK11 TNF 22802702 1714255 Positive_regulation MAPK11 TNF 22802702 1714268 Positive_regulation MAPK11 TNF 22802702 1714301 Positive_regulation MAPK11 TNF 22988345 1750558 Positive_regulation MAPK11 TNF 23028407 2219761 Positive_regulation MAPK11 TNF 23071583 2703146 Positive_regulation MAPK11 TNF 23071583 2703167 Positive_regulation MAPK11 TNF 23152905 2716805 Positive_regulation MAPK11 TNF 23190711 1665175 Positive_regulation MAPK11 TNF 23282009 1665852 Positive_regulation MAPK11 TNF 23326019 1751331 Positive_regulation MAPK11 TNF 23331383 1675503 Positive_regulation MAPK11 TNF 23533994 180656 Positive_regulation MAPK11 TNF 23626383 1046749 Positive_regulation MAPK11 TNF 23671702 2792491 Positive_regulation MAPK11 TNF 23688423 314298 Positive_regulation MAPK11 TNF 23690670 1752154 Positive_regulation MAPK11 TNF 23755184 2801836 Positive_regulation MAPK11 TNF 23784308 606113 Positive_regulation MAPK11 TNF 23784308 606130 Positive_regulation MAPK11 TNF 23967215 2834990 Positive_regulation MAPK11 TNF 23977119 2838448 Positive_regulation MAPK11 TNF 24008729 565160 Positive_regulation MAPK11 TNF 24008729 565508 Positive_regulation MAPK11 TNF 24024042 2003209 Positive_regulation MAPK11 TNF 24069158 2851378 Positive_regulation MAPK11 TNF 24069158 2851542 Positive_regulation MAPK11 TNF 24069158 2851543 Positive_regulation MAPK11 TNF 24086560 2854625 Positive_regulation MAPK11 TNF 24101950 2227320 Positive_regulation MAPK11 TNF 24244348 2879494 Positive_regulation MAPK11 TNF 24266983 240387 Positive_regulation MAPK11 TNF 24285913 737678 Positive_regulation MAPK11 TNF 24307884 3155525 Positive_regulation MAPK11 TNF 24377382 3225644 Positive_regulation MAPK11 TNF 24423080 538872 Positive_regulation MAPK11 TNF 24460683 240487 Positive_regulation MAPK11 TNF 24487321 1959837 Positive_regulation MAPK11 TNF 24489443 1757404 Positive_regulation MAPK11 TNF 24502696 1233040 Positive_regulation MAPK11 TNF 24502696 1233063 Positive_regulation MAPK11 TNF 24502696 1233112 Positive_regulation MAPK11 TNF 24502696 1233113 Positive_regulation MAPK11 TNF 24502696 1233157 Positive_regulation MAPK11 TNF 24502696 1233158 Positive_regulation MAPK11 TNF 24502696 1233219 Positive_regulation MAPK11 TNF 24502696 1233262 Positive_regulation MAPK11 TNF 24502696 1233293 Positive_regulation MAPK11 TNF 24587316 2929411 Positive_regulation MAPK11 TNF 24614867 2933182 Positive_regulation MAPK11 TNF 24616552 1757557 Positive_regulation MAPK11 TNF 24707477 188318 Positive_regulation MAPK11 TNF 24707477 188434 Positive_regulation MAPK11 TNF 24707477 188464 Positive_regulation MAPK11 TNF 24758719 1483148 Positive_regulation MAPK11 TNF 24773466 34204 Positive_regulation MAPK11 TNF 24821138 2969096 Positive_regulation MAPK11 TNF 24886088 347467 Positive_regulation MAPK11 TNF 25090227 2995082 Positive_regulation MAPK11 TNF 25110549 2229787 Positive_regulation MAPK11 TNF 25114952 3156813 Positive_regulation MAPK11 TNF 25114952 3156829 Positive_regulation MAPK11 TNF 25152756 826691 Positive_regulation MAPK11 TNF 25196285 3224111 Positive_regulation MAPK11 TNF 25206704 2005724 Positive_regulation MAPK11 TNF 25435878 1074931 Positive_regulation MAPK11 TNF 7525608 1436376 Positive_regulation MAPK11 TNF 7530764 1589997 Positive_regulation MAPK11 TNF 8562342 445246 Positive_regulation MAPK11 TNF 8666946 1597667 Positive_regulation MAPK11 TNFSF10 22462553 1230459 Positive_regulation MAPK11 TNFSF10 22719861 2653316 Positive_regulation MAPK12 ALOX5 22363611 2601202 Positive_regulation MAPK12 ALOX5 25025775 2989412 Positive_regulation MAPK12 ANGPT1 24013716 2842150 Positive_regulation MAPK12 ANGPT1 25329960 3017096 Positive_regulation MAPK12 ARSA 20339548 2444461 Positive_regulation MAPK12 ARSA 20339548 2444489 Positive_regulation MAPK12 CAPN8 24416390 2908349 Positive_regulation MAPK12 CCND1 22220184 1155994 Positive_regulation MAPK12 CCND1 25047753 240905 Positive_regulation MAPK12 CD14 20011115 3045931 Positive_regulation MAPK12 CD14 21387014 2506184 Positive_regulation MAPK12 CD14 24376813 2902220 Positive_regulation MAPK12 CHI3L1 23755018 961371 Positive_regulation MAPK12 CHI3L1 23972995 608993 Positive_regulation MAPK12 CHI3L1 23972995 608994 Positive_regulation MAPK12 CHI3L1 24729664 1758069 Positive_regulation MAPK12 CTGF 22135505 3128246 Positive_regulation MAPK12 CTGF 22918238 541772 Positive_regulation MAPK12 CTGF 23383241 2749641 Positive_regulation MAPK12 CTGF 23946690 1716065 Positive_regulation MAPK12 CYP24A1 22577546 1139589 Positive_regulation MAPK12 EDN2 12369712 1077806 Positive_regulation MAPK12 EDN2 24695532 2948230 Positive_regulation MAPK12 EPHB2 11783444 2001210 Positive_regulation MAPK12 EPHB2 18578886 356867 Positive_regulation MAPK12 EPHB2 19047466 1361966 Positive_regulation MAPK12 EPHB2 19047466 1361967 Positive_regulation MAPK12 EPHB2 19047466 1361968 Positive_regulation MAPK12 EPHB2 19047466 1362099 Positive_regulation MAPK12 EPHB2 19047466 1362100 Positive_regulation MAPK12 EPHB2 19047466 1362135 Positive_regulation MAPK12 EPHB2 19107595 1027486 Positive_regulation MAPK12 EPHB2 19357636 1902956 Positive_regulation MAPK12 EPHB2 20100173 212588 Positive_regulation MAPK12 EPHB2 21488184 3232786 Positive_regulation MAPK12 EPHB2 21488184 3232787 Positive_regulation MAPK12 EPHB2 21876711 813184 Positive_regulation MAPK12 EPHB2 22294469 135334 Positive_regulation MAPK12 EPHB2 22507553 1661711 Positive_regulation MAPK12 EPHB2 22675451 2648334 Positive_regulation MAPK12 EPHB2 22719861 2653319 Positive_regulation MAPK12 EPHB2 22723883 2655011 Positive_regulation MAPK12 EPHB2 22741533 381923 Positive_regulation MAPK12 EPHB2 22951718 1631190 Positive_regulation MAPK12 EPHB2 23383241 2749642 Positive_regulation MAPK12 EPHB2 23388501 1920508 Positive_regulation MAPK12 EPHB2 23738323 181923 Positive_regulation MAPK12 EPHB2 23826208 2811463 Positive_regulation MAPK12 EPHB2 24098984 1726342 Positive_regulation MAPK12 EPHB2 24823621 1624665 Positive_regulation MAPK12 EPHB2 24885161 396504 Positive_regulation MAPK12 EPHB2 24978597 2985605 Positive_regulation MAPK12 EPHB2 25299961 174472 Positive_regulation MAPK12 F2R 21378407 2175456 Positive_regulation MAPK12 F2R 21760880 2535497 Positive_regulation MAPK12 F2R 21760880 2535759 Positive_regulation MAPK12 F2R 21845431 3158097 Positive_regulation MAPK12 F2R 24215724 538273 Positive_regulation MAPK12 F2R 24278684 3150066 Positive_regulation MAPK12 F2R 24743392 2955210 Positive_regulation MAPK12 F2R 24743392 2955342 Positive_regulation MAPK12 F2R 24743392 2955410 Positive_regulation MAPK12 F2R 24860547 880676 Positive_regulation MAPK12 FAS 11259103 418445 Positive_regulation MAPK12 FAS 14970175 1531121 Positive_regulation MAPK12 FAS 19487421 1555058 Positive_regulation MAPK12 FAS 19564926 1055587 Positive_regulation MAPK12 FAS 20573240 1856427 Positive_regulation MAPK12 FAS 20573240 1856453 Positive_regulation MAPK12 FAS 21477291 527142 Positive_regulation MAPK12 FAS 21975294 552688 Positive_regulation MAPK12 FAS 21975294 552689 Positive_regulation MAPK12 FAS 21975294 552690 Positive_regulation MAPK12 FAS 21975294 552691 Positive_regulation MAPK12 FAS 21975294 552692 Positive_regulation MAPK12 FAS 21975294 552693 Positive_regulation MAPK12 FAS 21975294 552795 Positive_regulation MAPK12 FAS 21975294 552796 Positive_regulation MAPK12 FAS 21975294 552797 Positive_regulation MAPK12 FAS 21975294 552898 Positive_regulation MAPK12 FAS 21975294 552899 Positive_regulation MAPK12 FAS 21975294 552900 Positive_regulation MAPK12 FAS 21975294 553051 Positive_regulation MAPK12 FAS 23029562 2698769 Positive_regulation MAPK12 FAS 23029562 2698790 Positive_regulation MAPK12 FAS 23852022 1108459 Positive_regulation MAPK12 FAS 25196936 1730927 Positive_regulation MAPK12 FAS 9362518 1464809 Positive_regulation MAPK12 FBXO32 22082477 682637 Positive_regulation MAPK12 FBXO32 23046544 3161236 Positive_regulation MAPK12 FOXO1 20375467 26961 Positive_regulation MAPK12 GLP1R 23536825 2773060 Positive_regulation MAPK12 GPR115 22570668 635239 Positive_regulation MAPK12 GPR132 22570668 635228 Positive_regulation MAPK12 GPR87 22570668 635308 Positive_regulation MAPK12 HBEGF 15817123 1844603 Positive_regulation MAPK12 HBEGF 15817123 1844687 Positive_regulation MAPK12 HBEGF 22259731 1146100 Positive_regulation MAPK12 HBEGF 22792252 2661658 Positive_regulation MAPK12 HBEGF PMC3760629 1606201 Positive_regulation MAPK12 IFI27 11560992 1520878 Positive_regulation MAPK12 ITGB2 21206905 2491108 Positive_regulation MAPK12 ITGB2 23508943 906512 Positive_regulation MAPK12 MAP2K6 10330402 1246234 Positive_regulation MAPK12 MAP2K6 10737387 416977 Positive_regulation MAPK12 MAP2K6 11259103 418447 Positive_regulation MAPK12 MAP2K6 12117640 791067 Positive_regulation MAPK12 MAP2K6 14981092 1306449 Positive_regulation MAPK12 MAP2K6 16048647 3105317 Positive_regulation MAPK12 MAP2K6 17525795 2013996 Positive_regulation MAPK12 MAP2K6 17576777 1546442 Positive_regulation MAPK12 MAP2K6 18955270 810955 Positive_regulation MAPK12 MAP2K6 19159010 1055157 Positive_regulation MAPK12 MAP2K6 19159010 1055375 Positive_regulation MAPK12 MAP2K6 19426550 282532 Positive_regulation MAPK12 MAP2K6 20221403 2442589 Positive_regulation MAPK12 MAP2K6 20463961 2449783 Positive_regulation MAPK12 MAP2K6 20802223 2253138 Positive_regulation MAPK12 MAP2K6 20955562 120547 Positive_regulation MAPK12 MAP2K6 20955562 120651 Positive_regulation MAPK12 MAP2K6 21345249 121638 Positive_regulation MAPK12 MAP2K6 22028883 2564915 Positive_regulation MAPK12 MAP2K6 22159586 600562 Positive_regulation MAPK12 MAP2K6 22245064 613564 Positive_regulation MAPK12 MAP2K6 22359624 2598514 Positive_regulation MAPK12 MAP2K6 22415879 722007 Positive_regulation MAPK12 MAP2K6 22415879 722337 Positive_regulation MAPK12 MAP2K6 22529896 2620565 Positive_regulation MAPK12 MAP2K6 22740774 490698 Positive_regulation MAPK12 MAP2K6 22870983 288767 Positive_regulation MAPK12 MAP2K6 22870983 288906 Positive_regulation MAPK12 MAP2K6 22870983 289015 Positive_regulation MAPK12 MAP2K6 23115639 2711453 Positive_regulation MAPK12 MAP2K6 23166686 2718483 Positive_regulation MAPK12 MAP2K6 23535559 1721148 Positive_regulation MAPK12 MAP2K6 23772401 852437 Positive_regulation MAPK12 MAP2K6 23936348 2830115 Positive_regulation MAPK12 MAP2K6 24566153 1124333 Positive_regulation MAPK12 MAP2K6 24792484 2960459 Positive_regulation MAPK12 MAP2K6 25364728 861775 Positive_regulation MAPK12 MAP2K6 25479605 3032531 Positive_regulation MAPK12 MAP2K6 9700154 1469448 Positive_regulation MAPK12 MIP 19781090 1625738 Positive_regulation MAPK12 MIP 21977329 1082347 Positive_regulation MAPK12 MMP28 18778487 384789 Positive_regulation MAPK12 MMP28 23688423 313876 Positive_regulation MAPK12 MMP28 23688423 314327 Positive_regulation MAPK12 MMP28 23878609 821797 Positive_regulation MAPK12 MMP28 25520932 203054 Positive_regulation MAPK12 MMP7 23688423 313891 Positive_regulation MAPK12 MMP7 23688423 314343 Positive_regulation MAPK12 MMP7 23878609 821813 Positive_regulation MAPK12 MMP7 25520932 203069 Positive_regulation MAPK12 MUC16 17029558 2303033 Positive_regulation MAPK12 MUC16 23694968 3135913 Positive_regulation MAPK12 NGFR 22880054 2673865 Positive_regulation MAPK12 NR2F1 24906407 273648 Positive_regulation MAPK12 OXTR 22190926 1072836 Positive_regulation MAPK12 PLAU 23724131 2799121 Positive_regulation MAPK12 PLAU 23724131 2799385 Positive_regulation MAPK12 PTGER2 25327961 216574 Positive_regulation MAPK12 RCAN1 19124655 1553352 Positive_regulation MAPK12 RCAN1 19124655 1553472 Positive_regulation MAPK12 RGS2 24743392 2955343 Positive_regulation MAPK12 S100B 22276098 2589821 Positive_regulation MAPK12 S100B 23259641 1665764 Positive_regulation MAPK12 S100B 23259641 1665778 Positive_regulation MAPK12 S100B 23259641 1665792 Positive_regulation MAPK12 SCGB3A1 22289642 335845 Positive_regulation MAPK12 SLC6A2 18509476 2389898 Positive_regulation MAPK12 SPHK1 16847102 1331300 Positive_regulation MAPK12 SPHK1 20498849 2451133 Positive_regulation MAPK12 SPHK1 20498849 2451168 Positive_regulation MAPK12 TLR7 19043549 3042373 Positive_regulation MAPK12 TLR7 19043549 3042517 Positive_regulation MAPK12 TLR7 19371402 733941 Positive_regulation MAPK12 TLR7 19685283 495382 Positive_regulation MAPK12 TLR7 20832340 1040234 Positive_regulation MAPK12 TLR7 21633096 1992407 Positive_regulation MAPK12 TLR7 21743791 1028435 Positive_regulation MAPK12 TLR7 21943110 2231337 Positive_regulation MAPK12 TLR7 22110382 1058313 Positive_regulation MAPK12 TLR7 22216226 2584818 Positive_regulation MAPK12 TLR7 22829768 3058379 Positive_regulation MAPK12 TLR7 23202320 3184664 Positive_regulation MAPK12 TLR7 23305364 693970 Positive_regulation MAPK12 TLR7 23521892 3215308 Positive_regulation MAPK12 TLR7 23603814 1962845 Positive_regulation MAPK12 TLR7 23760366 2211902 Positive_regulation MAPK12 TLR7 23840534 2814977 Positive_regulation MAPK12 TLR7 24489933 2916811 Positive_regulation MAPK12 TLR7 24603716 2932051 Positive_regulation MAPK12 TLR7 24772440 189706 Positive_regulation MAPK12 TLR7 24800851 2961024 Positive_regulation MAPK12 TLR7 25177436 646966 Positive_regulation MAPK12 TNF 11015442 1517386 Positive_regulation MAPK12 TNF 11015442 1517421 Positive_regulation MAPK12 TNF 11015442 1517434 Positive_regulation MAPK12 TNF 11015442 1517447 Positive_regulation MAPK12 TNF 14613529 3095424 Positive_regulation MAPK12 TNF 15157285 277600 Positive_regulation MAPK12 TNF 15642133 102179 Positive_regulation MAPK12 TNF 15781582 1535126 Positive_regulation MAPK12 TNF 15841081 425532 Positive_regulation MAPK12 TNF 15841081 425533 Positive_regulation MAPK12 TNF 15841081 425870 Positive_regulation MAPK12 TNF 16100442 1634523 Positive_regulation MAPK12 TNF 16100442 1634630 Positive_regulation MAPK12 TNF 16207331 104241 Positive_regulation MAPK12 TNF 16207331 104277 Positive_regulation MAPK12 TNF 16207331 104278 Positive_regulation MAPK12 TNF 16207331 104320 Positive_regulation MAPK12 TNF 16207331 104321 Positive_regulation MAPK12 TNF 16207331 104353 Positive_regulation MAPK12 TNF 16207342 104517 Positive_regulation MAPK12 TNF 16207342 104569 Positive_regulation MAPK12 TNF 17283208 1544257 Positive_regulation MAPK12 TNF 17342245 810729 Positive_regulation MAPK12 TNF 18096615 2032346 Positive_regulation MAPK12 TNF 18404427 3087184 Positive_regulation MAPK12 TNF 18410682 110440 Positive_regulation MAPK12 TNF 19343193 1746544 Positive_regulation MAPK12 TNF 19442267 1696269 Positive_regulation MAPK12 TNF 19707336 175497 Positive_regulation MAPK12 TNF 19723340 1227347 Positive_regulation MAPK12 TNF 19723340 1227362 Positive_regulation MAPK12 TNF 19723340 1227376 Positive_regulation MAPK12 TNF 20157567 26215 Positive_regulation MAPK12 TNF 20157567 26447 Positive_regulation MAPK12 TNF 20308428 1373860 Positive_regulation MAPK12 TNF 20418897 9887 Positive_regulation MAPK12 TNF 20529221 34776 Positive_regulation MAPK12 TNF 20615213 119633 Positive_regulation MAPK12 TNF 20644550 10421 Positive_regulation MAPK12 TNF 20844314 27774 Positive_regulation MAPK12 TNF 20844314 28237 Positive_regulation MAPK12 TNF 20871620 11947 Positive_regulation MAPK12 TNF 21386087 718532 Positive_regulation MAPK12 TNF 21423395 955229 Positive_regulation MAPK12 TNF 21485745 734908 Positive_regulation MAPK12 TNF 21572963 2520298 Positive_regulation MAPK12 TNF 21837268 1082182 Positive_regulation MAPK12 TNF 21867555 1659577 Positive_regulation MAPK12 TNF 21871121 1659628 Positive_regulation MAPK12 TNF 22082477 682551 Positive_regulation MAPK12 TNF 22194685 3055229 Positive_regulation MAPK12 TNF 22802702 1714256 Positive_regulation MAPK12 TNF 22802702 1714269 Positive_regulation MAPK12 TNF 22802702 1714302 Positive_regulation MAPK12 TNF 22988345 1750559 Positive_regulation MAPK12 TNF 23028407 2219765 Positive_regulation MAPK12 TNF 23071583 2703147 Positive_regulation MAPK12 TNF 23071583 2703168 Positive_regulation MAPK12 TNF 23152905 2716806 Positive_regulation MAPK12 TNF 23190711 1665176 Positive_regulation MAPK12 TNF 23282009 1665853 Positive_regulation MAPK12 TNF 23326019 1751332 Positive_regulation MAPK12 TNF 23331383 1675505 Positive_regulation MAPK12 TNF 23533994 180657 Positive_regulation MAPK12 TNF 23626383 1046751 Positive_regulation MAPK12 TNF 23671702 2792492 Positive_regulation MAPK12 TNF 23688423 314322 Positive_regulation MAPK12 TNF 23690670 1752156 Positive_regulation MAPK12 TNF 23755184 2801837 Positive_regulation MAPK12 TNF 23784308 606114 Positive_regulation MAPK12 TNF 23784308 606132 Positive_regulation MAPK12 TNF 23967215 2834993 Positive_regulation MAPK12 TNF 23977119 2838449 Positive_regulation MAPK12 TNF 24008729 565161 Positive_regulation MAPK12 TNF 24008729 565509 Positive_regulation MAPK12 TNF 24024042 2003210 Positive_regulation MAPK12 TNF 24069158 2851383 Positive_regulation MAPK12 TNF 24069158 2851544 Positive_regulation MAPK12 TNF 24069158 2851545 Positive_regulation MAPK12 TNF 24086560 2854626 Positive_regulation MAPK12 TNF 24101950 2227321 Positive_regulation MAPK12 TNF 24244348 2879495 Positive_regulation MAPK12 TNF 24266983 240388 Positive_regulation MAPK12 TNF 24285913 737679 Positive_regulation MAPK12 TNF 24307884 3155526 Positive_regulation MAPK12 TNF 24377382 3225645 Positive_regulation MAPK12 TNF 24423080 538873 Positive_regulation MAPK12 TNF 24460683 240488 Positive_regulation MAPK12 TNF 24487321 1959838 Positive_regulation MAPK12 TNF 24489443 1757405 Positive_regulation MAPK12 TNF 24502696 1233041 Positive_regulation MAPK12 TNF 24502696 1233064 Positive_regulation MAPK12 TNF 24502696 1233114 Positive_regulation MAPK12 TNF 24502696 1233115 Positive_regulation MAPK12 TNF 24502696 1233159 Positive_regulation MAPK12 TNF 24502696 1233160 Positive_regulation MAPK12 TNF 24502696 1233220 Positive_regulation MAPK12 TNF 24502696 1233264 Positive_regulation MAPK12 TNF 24502696 1233294 Positive_regulation MAPK12 TNF 24587316 2929412 Positive_regulation MAPK12 TNF 24614867 2933183 Positive_regulation MAPK12 TNF 24616552 1757558 Positive_regulation MAPK12 TNF 24707477 188323 Positive_regulation MAPK12 TNF 24707477 188435 Positive_regulation MAPK12 TNF 24707477 188465 Positive_regulation MAPK12 TNF 24758719 1483149 Positive_regulation MAPK12 TNF 24773466 34205 Positive_regulation MAPK12 TNF 24821138 2969097 Positive_regulation MAPK12 TNF 24886088 347468 Positive_regulation MAPK12 TNF 25090227 2995083 Positive_regulation MAPK12 TNF 25110549 2229788 Positive_regulation MAPK12 TNF 25114952 3156814 Positive_regulation MAPK12 TNF 25114952 3156830 Positive_regulation MAPK12 TNF 25152756 826693 Positive_regulation MAPK12 TNF 25196285 3224112 Positive_regulation MAPK12 TNF 25206704 2005725 Positive_regulation MAPK12 TNF 25435878 1074932 Positive_regulation MAPK12 TNF 7525608 1436377 Positive_regulation MAPK12 TNF 7530764 1589998 Positive_regulation MAPK12 TNF 8562342 445247 Positive_regulation MAPK12 TNF 8666946 1597668 Positive_regulation MAPK12 TNFSF10 22462553 1230460 Positive_regulation MAPK12 TNFSF10 22719861 2653318 Positive_regulation MAPK13 ALOX5 22363611 2601203 Positive_regulation MAPK13 ALOX5 25025775 2989413 Positive_regulation MAPK13 ANGPT1 24013716 2842151 Positive_regulation MAPK13 ANGPT1 25329960 3017099 Positive_regulation MAPK13 ARSA 20339548 2444462 Positive_regulation MAPK13 ARSA 20339548 2444490 Positive_regulation MAPK13 CAPN8 24416390 2908363 Positive_regulation MAPK13 CCND1 22220184 1155995 Positive_regulation MAPK13 CCND1 25047753 240913 Positive_regulation MAPK13 CD14 20011115 3045932 Positive_regulation MAPK13 CD14 21387014 2506185 Positive_regulation MAPK13 CD14 24376813 2902223 Positive_regulation MAPK13 CHI3L1 23755018 961374 Positive_regulation MAPK13 CHI3L1 23972995 608995 Positive_regulation MAPK13 CHI3L1 23972995 608996 Positive_regulation MAPK13 CHI3L1 24729664 1758070 Positive_regulation MAPK13 CTGF 22135505 3128247 Positive_regulation MAPK13 CTGF 22918238 541773 Positive_regulation MAPK13 CTGF 23383241 2749643 Positive_regulation MAPK13 CTGF 23946690 1716066 Positive_regulation MAPK13 CYP24A1 22577546 1139590 Positive_regulation MAPK13 EDN2 12369712 1077809 Positive_regulation MAPK13 EDN2 24695532 2948233 Positive_regulation MAPK13 EPHB2 11783444 2001211 Positive_regulation MAPK13 EPHB2 18578886 356868 Positive_regulation MAPK13 EPHB2 19047466 1361969 Positive_regulation MAPK13 EPHB2 19047466 1361970 Positive_regulation MAPK13 EPHB2 19047466 1361971 Positive_regulation MAPK13 EPHB2 19047466 1362101 Positive_regulation MAPK13 EPHB2 19047466 1362102 Positive_regulation MAPK13 EPHB2 19047466 1362136 Positive_regulation MAPK13 EPHB2 19107595 1027488 Positive_regulation MAPK13 EPHB2 19357636 1902958 Positive_regulation MAPK13 EPHB2 20100173 212589 Positive_regulation MAPK13 EPHB2 21488184 3232788 Positive_regulation MAPK13 EPHB2 21488184 3232789 Positive_regulation MAPK13 EPHB2 21876711 813185 Positive_regulation MAPK13 EPHB2 22294469 135335 Positive_regulation MAPK13 EPHB2 22507553 1661717 Positive_regulation MAPK13 EPHB2 22675451 2648337 Positive_regulation MAPK13 EPHB2 22719861 2653321 Positive_regulation MAPK13 EPHB2 22723883 2655012 Positive_regulation MAPK13 EPHB2 22741533 381925 Positive_regulation MAPK13 EPHB2 22951718 1631191 Positive_regulation MAPK13 EPHB2 23383241 2749644 Positive_regulation MAPK13 EPHB2 23388501 1920509 Positive_regulation MAPK13 EPHB2 23738323 181925 Positive_regulation MAPK13 EPHB2 23826208 2811464 Positive_regulation MAPK13 EPHB2 24098984 1726343 Positive_regulation MAPK13 EPHB2 24823621 1624666 Positive_regulation MAPK13 EPHB2 24885161 396505 Positive_regulation MAPK13 EPHB2 24978597 2985606 Positive_regulation MAPK13 EPHB2 25299961 174473 Positive_regulation MAPK13 F2R 21378407 2175457 Positive_regulation MAPK13 F2R 21760880 2535503 Positive_regulation MAPK13 F2R 21760880 2535765 Positive_regulation MAPK13 F2R 21845431 3158098 Positive_regulation MAPK13 F2R 24215724 538274 Positive_regulation MAPK13 F2R 24278684 3150067 Positive_regulation MAPK13 F2R 24743392 2955213 Positive_regulation MAPK13 F2R 24743392 2955345 Positive_regulation MAPK13 F2R 24743392 2955411 Positive_regulation MAPK13 F2R 24860547 880679 Positive_regulation MAPK13 FAS 11259103 418448 Positive_regulation MAPK13 FAS 14970175 1531122 Positive_regulation MAPK13 FAS 19487421 1555060 Positive_regulation MAPK13 FAS 19564926 1055588 Positive_regulation MAPK13 FAS 20573240 1856428 Positive_regulation MAPK13 FAS 20573240 1856454 Positive_regulation MAPK13 FAS 21477291 527143 Positive_regulation MAPK13 FAS 21975294 552694 Positive_regulation MAPK13 FAS 21975294 552695 Positive_regulation MAPK13 FAS 21975294 552696 Positive_regulation MAPK13 FAS 21975294 552697 Positive_regulation MAPK13 FAS 21975294 552698 Positive_regulation MAPK13 FAS 21975294 552699 Positive_regulation MAPK13 FAS 21975294 552798 Positive_regulation MAPK13 FAS 21975294 552799 Positive_regulation MAPK13 FAS 21975294 552800 Positive_regulation MAPK13 FAS 21975294 552904 Positive_regulation MAPK13 FAS 21975294 552905 Positive_regulation MAPK13 FAS 21975294 552906 Positive_regulation MAPK13 FAS 21975294 553065 Positive_regulation MAPK13 FAS 23029562 2698770 Positive_regulation MAPK13 FAS 23029562 2698791 Positive_regulation MAPK13 FAS 23852022 1108460 Positive_regulation MAPK13 FAS 25196936 1730929 Positive_regulation MAPK13 FAS 9362518 1464811 Positive_regulation MAPK13 FBXO32 22082477 682640 Positive_regulation MAPK13 FBXO32 23046544 3161237 Positive_regulation MAPK13 FOXO1 20375467 26965 Positive_regulation MAPK13 GLP1R 23536825 2773061 Positive_regulation MAPK13 GPR115 22570668 635332 Positive_regulation MAPK13 GPR132 22570668 635321 Positive_regulation MAPK13 GPR87 22570668 635401 Positive_regulation MAPK13 HBEGF 15817123 1844606 Positive_regulation MAPK13 HBEGF 15817123 1844689 Positive_regulation MAPK13 HBEGF 22259731 1146101 Positive_regulation MAPK13 HBEGF 22792252 2661659 Positive_regulation MAPK13 HBEGF PMC3760629 1606202 Positive_regulation MAPK13 IFI27 11560992 1520880 Positive_regulation MAPK13 ITGB2 21206905 2491110 Positive_regulation MAPK13 ITGB2 23508943 906514 Positive_regulation MAPK13 MAP2K6 10330402 1246236 Positive_regulation MAPK13 MAP2K6 10737387 416984 Positive_regulation MAPK13 MAP2K6 11259103 418450 Positive_regulation MAPK13 MAP2K6 12117640 791074 Positive_regulation MAPK13 MAP2K6 14981092 1306457 Positive_regulation MAPK13 MAP2K6 16048647 3105324 Positive_regulation MAPK13 MAP2K6 17525795 2013997 Positive_regulation MAPK13 MAP2K6 17576777 1546449 Positive_regulation MAPK13 MAP2K6 18955270 810968 Positive_regulation MAPK13 MAP2K6 19159010 1055158 Positive_regulation MAPK13 MAP2K6 19159010 1055376 Positive_regulation MAPK13 MAP2K6 19426550 282539 Positive_regulation MAPK13 MAP2K6 20221403 2442591 Positive_regulation MAPK13 MAP2K6 20463961 2449785 Positive_regulation MAPK13 MAP2K6 20802223 2253139 Positive_regulation MAPK13 MAP2K6 20955562 120551 Positive_regulation MAPK13 MAP2K6 20955562 120653 Positive_regulation MAPK13 MAP2K6 21345249 121645 Positive_regulation MAPK13 MAP2K6 22028883 2564922 Positive_regulation MAPK13 MAP2K6 22159586 600569 Positive_regulation MAPK13 MAP2K6 22245064 613571 Positive_regulation MAPK13 MAP2K6 22359624 2598522 Positive_regulation MAPK13 MAP2K6 22415879 722012 Positive_regulation MAPK13 MAP2K6 22415879 722342 Positive_regulation MAPK13 MAP2K6 22529896 2620572 Positive_regulation MAPK13 MAP2K6 22740774 490705 Positive_regulation MAPK13 MAP2K6 22870983 288768 Positive_regulation MAPK13 MAP2K6 22870983 288907 Positive_regulation MAPK13 MAP2K6 22870983 289016 Positive_regulation MAPK13 MAP2K6 23115639 2711455 Positive_regulation MAPK13 MAP2K6 23166686 2718490 Positive_regulation MAPK13 MAP2K6 23535559 1721157 Positive_regulation MAPK13 MAP2K6 23772401 852476 Positive_regulation MAPK13 MAP2K6 23936348 2830122 Positive_regulation MAPK13 MAP2K6 24566153 1124340 Positive_regulation MAPK13 MAP2K6 24792484 2960466 Positive_regulation MAPK13 MAP2K6 25364728 861777 Positive_regulation MAPK13 MAP2K6 25479605 3032538 Positive_regulation MAPK13 MAP2K6 9700154 1469455 Positive_regulation MAPK13 MIP 19781090 1625739 Positive_regulation MAPK13 MIP 21977329 1082348 Positive_regulation MAPK13 MMP28 18778487 384790 Positive_regulation MAPK13 MMP28 23688423 313898 Positive_regulation MAPK13 MMP28 23688423 314351 Positive_regulation MAPK13 MMP28 23878609 821820 Positive_regulation MAPK13 MMP28 25520932 203076 Positive_regulation MAPK13 MMP7 23688423 313913 Positive_regulation MAPK13 MMP7 23688423 314367 Positive_regulation MAPK13 MMP7 23878609 821836 Positive_regulation MAPK13 MMP7 25520932 203091 Positive_regulation MAPK13 MUC16 17029558 2303049 Positive_regulation MAPK13 MUC16 23694968 3135916 Positive_regulation MAPK13 NGFR 22880054 2673867 Positive_regulation MAPK13 NR2F1 24906407 273649 Positive_regulation MAPK13 OXTR 22190926 1072837 Positive_regulation MAPK13 PLAU 23724131 2799123 Positive_regulation MAPK13 PLAU 23724131 2799386 Positive_regulation MAPK13 PTGER2 25327961 216575 Positive_regulation MAPK13 RCAN1 19124655 1553353 Positive_regulation MAPK13 RCAN1 19124655 1553473 Positive_regulation MAPK13 RGS2 24743392 2955346 Positive_regulation MAPK13 S100B 22276098 2589823 Positive_regulation MAPK13 S100B 23259641 1665765 Positive_regulation MAPK13 S100B 23259641 1665779 Positive_regulation MAPK13 S100B 23259641 1665793 Positive_regulation MAPK13 SCGB3A1 22289642 335846 Positive_regulation MAPK13 SLC6A2 18509476 2389899 Positive_regulation MAPK13 SPHK1 16847102 1331302 Positive_regulation MAPK13 SPHK1 20498849 2451134 Positive_regulation MAPK13 SPHK1 20498849 2451169 Positive_regulation MAPK13 TLR7 19043549 3042383 Positive_regulation MAPK13 TLR7 19043549 3042527 Positive_regulation MAPK13 TLR7 19371402 733951 Positive_regulation MAPK13 TLR7 19685283 495392 Positive_regulation MAPK13 TLR7 20832340 1040235 Positive_regulation MAPK13 TLR7 21633096 1992417 Positive_regulation MAPK13 TLR7 21743791 1028445 Positive_regulation MAPK13 TLR7 21943110 2231347 Positive_regulation MAPK13 TLR7 22110382 1058323 Positive_regulation MAPK13 TLR7 22216226 2584828 Positive_regulation MAPK13 TLR7 22829768 3058389 Positive_regulation MAPK13 TLR7 23202320 3184675 Positive_regulation MAPK13 TLR7 23305364 693980 Positive_regulation MAPK13 TLR7 23521892 3215318 Positive_regulation MAPK13 TLR7 23603814 1962857 Positive_regulation MAPK13 TLR7 23760366 2211912 Positive_regulation MAPK13 TLR7 23840534 2814987 Positive_regulation MAPK13 TLR7 24489933 2916821 Positive_regulation MAPK13 TLR7 24603716 2932061 Positive_regulation MAPK13 TLR7 24772440 189716 Positive_regulation MAPK13 TLR7 24800851 2961034 Positive_regulation MAPK13 TLR7 25177436 646976 Positive_regulation MAPK13 TNF 11015442 1517388 Positive_regulation MAPK13 TNF 11015442 1517422 Positive_regulation MAPK13 TNF 11015442 1517435 Positive_regulation MAPK13 TNF 11015442 1517448 Positive_regulation MAPK13 TNF 14613529 3095425 Positive_regulation MAPK13 TNF 15157285 277601 Positive_regulation MAPK13 TNF 15642133 102181 Positive_regulation MAPK13 TNF 15781582 1535127 Positive_regulation MAPK13 TNF 15841081 425534 Positive_regulation MAPK13 TNF 15841081 425535 Positive_regulation MAPK13 TNF 15841081 425871 Positive_regulation MAPK13 TNF 16100442 1634535 Positive_regulation MAPK13 TNF 16100442 1634631 Positive_regulation MAPK13 TNF 16207331 104242 Positive_regulation MAPK13 TNF 16207331 104279 Positive_regulation MAPK13 TNF 16207331 104280 Positive_regulation MAPK13 TNF 16207331 104323 Positive_regulation MAPK13 TNF 16207331 104324 Positive_regulation MAPK13 TNF 16207331 104354 Positive_regulation MAPK13 TNF 16207342 104518 Positive_regulation MAPK13 TNF 16207342 104570 Positive_regulation MAPK13 TNF 17283208 1544258 Positive_regulation MAPK13 TNF 17342245 810730 Positive_regulation MAPK13 TNF 18096615 2032348 Positive_regulation MAPK13 TNF 18404427 3087185 Positive_regulation MAPK13 TNF 18410682 110441 Positive_regulation MAPK13 TNF 19343193 1746545 Positive_regulation MAPK13 TNF 19442267 1696270 Positive_regulation MAPK13 TNF 19707336 175499 Positive_regulation MAPK13 TNF 19723340 1227348 Positive_regulation MAPK13 TNF 19723340 1227363 Positive_regulation MAPK13 TNF 19723340 1227377 Positive_regulation MAPK13 TNF 20157567 26218 Positive_regulation MAPK13 TNF 20157567 26448 Positive_regulation MAPK13 TNF 20308428 1373861 Positive_regulation MAPK13 TNF 20418897 9888 Positive_regulation MAPK13 TNF 20529221 34777 Positive_regulation MAPK13 TNF 20615213 119636 Positive_regulation MAPK13 TNF 20644550 10422 Positive_regulation MAPK13 TNF 20844314 27775 Positive_regulation MAPK13 TNF 20844314 28238 Positive_regulation MAPK13 TNF 20871620 11948 Positive_regulation MAPK13 TNF 21386087 718534 Positive_regulation MAPK13 TNF 21423395 955231 Positive_regulation MAPK13 TNF 21485745 734910 Positive_regulation MAPK13 TNF 21572963 2520299 Positive_regulation MAPK13 TNF 21837268 1082183 Positive_regulation MAPK13 TNF 21867555 1659578 Positive_regulation MAPK13 TNF 21871121 1659629 Positive_regulation MAPK13 TNF 22082477 682553 Positive_regulation MAPK13 TNF 22194685 3055230 Positive_regulation MAPK13 TNF 22802702 1714257 Positive_regulation MAPK13 TNF 22802702 1714270 Positive_regulation MAPK13 TNF 22802702 1714303 Positive_regulation MAPK13 TNF 22988345 1750560 Positive_regulation MAPK13 TNF 23028407 2219769 Positive_regulation MAPK13 TNF 23071583 2703148 Positive_regulation MAPK13 TNF 23071583 2703169 Positive_regulation MAPK13 TNF 23152905 2716807 Positive_regulation MAPK13 TNF 23190711 1665177 Positive_regulation MAPK13 TNF 23282009 1665854 Positive_regulation MAPK13 TNF 23326019 1751333 Positive_regulation MAPK13 TNF 23331383 1675507 Positive_regulation MAPK13 TNF 23533994 180658 Positive_regulation MAPK13 TNF 23626383 1046753 Positive_regulation MAPK13 TNF 23671702 2792493 Positive_regulation MAPK13 TNF 23688423 314346 Positive_regulation MAPK13 TNF 23690670 1752158 Positive_regulation MAPK13 TNF 23755184 2801838 Positive_regulation MAPK13 TNF 23784308 606115 Positive_regulation MAPK13 TNF 23784308 606134 Positive_regulation MAPK13 TNF 23967215 2834996 Positive_regulation MAPK13 TNF 23977119 2838450 Positive_regulation MAPK13 TNF 24008729 565162 Positive_regulation MAPK13 TNF 24008729 565510 Positive_regulation MAPK13 TNF 24024042 2003211 Positive_regulation MAPK13 TNF 24069158 2851388 Positive_regulation MAPK13 TNF 24069158 2851546 Positive_regulation MAPK13 TNF 24069158 2851547 Positive_regulation MAPK13 TNF 24086560 2854627 Positive_regulation MAPK13 TNF 24101950 2227322 Positive_regulation MAPK13 TNF 24244348 2879496 Positive_regulation MAPK13 TNF 24266983 240389 Positive_regulation MAPK13 TNF 24285913 737680 Positive_regulation MAPK13 TNF 24307884 3155527 Positive_regulation MAPK13 TNF 24377382 3225646 Positive_regulation MAPK13 TNF 24423080 538874 Positive_regulation MAPK13 TNF 24460683 240489 Positive_regulation MAPK13 TNF 24487321 1959839 Positive_regulation MAPK13 TNF 24489443 1757406 Positive_regulation MAPK13 TNF 24502696 1233042 Positive_regulation MAPK13 TNF 24502696 1233065 Positive_regulation MAPK13 TNF 24502696 1233116 Positive_regulation MAPK13 TNF 24502696 1233117 Positive_regulation MAPK13 TNF 24502696 1233161 Positive_regulation MAPK13 TNF 24502696 1233162 Positive_regulation MAPK13 TNF 24502696 1233221 Positive_regulation MAPK13 TNF 24502696 1233266 Positive_regulation MAPK13 TNF 24502696 1233295 Positive_regulation MAPK13 TNF 24587316 2929413 Positive_regulation MAPK13 TNF 24614867 2933184 Positive_regulation MAPK13 TNF 24616552 1757559 Positive_regulation MAPK13 TNF 24707477 188328 Positive_regulation MAPK13 TNF 24707477 188436 Positive_regulation MAPK13 TNF 24707477 188466 Positive_regulation MAPK13 TNF 24758719 1483150 Positive_regulation MAPK13 TNF 24773466 34206 Positive_regulation MAPK13 TNF 24821138 2969098 Positive_regulation MAPK13 TNF 24886088 347469 Positive_regulation MAPK13 TNF 25090227 2995084 Positive_regulation MAPK13 TNF 25110549 2229789 Positive_regulation MAPK13 TNF 25114952 3156815 Positive_regulation MAPK13 TNF 25114952 3156831 Positive_regulation MAPK13 TNF 25152756 826695 Positive_regulation MAPK13 TNF 25196285 3224113 Positive_regulation MAPK13 TNF 25206704 2005726 Positive_regulation MAPK13 TNF 25435878 1074933 Positive_regulation MAPK13 TNF 7525608 1436378 Positive_regulation MAPK13 TNF 7530764 1589999 Positive_regulation MAPK13 TNF 8562342 445248 Positive_regulation MAPK13 TNF 8666946 1597669 Positive_regulation MAPK13 TNFSF10 22462553 1230461 Positive_regulation MAPK13 TNFSF10 22719861 2653320 Positive_regulation MAPK14 ALOX5 22363611 2601204 Positive_regulation MAPK14 ALOX5 25025775 2989414 Positive_regulation MAPK14 ANGPT1 24013716 2842152 Positive_regulation MAPK14 ANGPT1 25329960 3017102 Positive_regulation MAPK14 ARSA 20339548 2444463 Positive_regulation MAPK14 ARSA 20339548 2444491 Positive_regulation MAPK14 CAPN8 24416390 2908377 Positive_regulation MAPK14 CCND1 22220184 1155996 Positive_regulation MAPK14 CCND1 25047753 240921 Positive_regulation MAPK14 CD14 20011115 3045933 Positive_regulation MAPK14 CD14 21387014 2506186 Positive_regulation MAPK14 CD14 24376813 2902226 Positive_regulation MAPK14 CHI3L1 23755018 961377 Positive_regulation MAPK14 CHI3L1 23972995 608997 Positive_regulation MAPK14 CHI3L1 23972995 608998 Positive_regulation MAPK14 CHI3L1 24729664 1758071 Positive_regulation MAPK14 CTGF 22135505 3128248 Positive_regulation MAPK14 CTGF 22918238 541774 Positive_regulation MAPK14 CTGF 23383241 2749645 Positive_regulation MAPK14 CTGF 23946690 1716067 Positive_regulation MAPK14 CYP24A1 22577546 1139591 Positive_regulation MAPK14 EDN2 12369712 1077812 Positive_regulation MAPK14 EDN2 24695532 2948236 Positive_regulation MAPK14 EPHB2 11783444 2001212 Positive_regulation MAPK14 EPHB2 18578886 356869 Positive_regulation MAPK14 EPHB2 19047466 1361972 Positive_regulation MAPK14 EPHB2 19047466 1361973 Positive_regulation MAPK14 EPHB2 19047466 1361974 Positive_regulation MAPK14 EPHB2 19047466 1362103 Positive_regulation MAPK14 EPHB2 19047466 1362104 Positive_regulation MAPK14 EPHB2 19047466 1362137 Positive_regulation MAPK14 EPHB2 19107595 1027490 Positive_regulation MAPK14 EPHB2 19357636 1902960 Positive_regulation MAPK14 EPHB2 20100173 212590 Positive_regulation MAPK14 EPHB2 21488184 3232790 Positive_regulation MAPK14 EPHB2 21488184 3232791 Positive_regulation MAPK14 EPHB2 21876711 813186 Positive_regulation MAPK14 EPHB2 22294469 135336 Positive_regulation MAPK14 EPHB2 22507553 1661723 Positive_regulation MAPK14 EPHB2 22675451 2648340 Positive_regulation MAPK14 EPHB2 22719861 2653323 Positive_regulation MAPK14 EPHB2 22723883 2655013 Positive_regulation MAPK14 EPHB2 22741533 381927 Positive_regulation MAPK14 EPHB2 22951718 1631192 Positive_regulation MAPK14 EPHB2 23383241 2749646 Positive_regulation MAPK14 EPHB2 23388501 1920510 Positive_regulation MAPK14 EPHB2 23738323 181927 Positive_regulation MAPK14 EPHB2 23826208 2811465 Positive_regulation MAPK14 EPHB2 24098984 1726344 Positive_regulation MAPK14 EPHB2 24823621 1624667 Positive_regulation MAPK14 EPHB2 24885161 396506 Positive_regulation MAPK14 EPHB2 24978597 2985607 Positive_regulation MAPK14 EPHB2 25299961 174474 Positive_regulation MAPK14 F2R 21378407 2175458 Positive_regulation MAPK14 F2R 21760880 2535509 Positive_regulation MAPK14 F2R 21760880 2535771 Positive_regulation MAPK14 F2R 21845431 3158099 Positive_regulation MAPK14 F2R 24215724 538275 Positive_regulation MAPK14 F2R 24278684 3150068 Positive_regulation MAPK14 F2R 24743392 2955216 Positive_regulation MAPK14 F2R 24743392 2955348 Positive_regulation MAPK14 F2R 24743392 2955412 Positive_regulation MAPK14 F2R 24860547 880682 Positive_regulation MAPK14 FAS 11259103 418451 Positive_regulation MAPK14 FAS 14970175 1531123 Positive_regulation MAPK14 FAS 19487421 1555062 Positive_regulation MAPK14 FAS 19564926 1055589 Positive_regulation MAPK14 FAS 20573240 1856429 Positive_regulation MAPK14 FAS 20573240 1856455 Positive_regulation MAPK14 FAS 21477291 527144 Positive_regulation MAPK14 FAS 21975294 552700 Positive_regulation MAPK14 FAS 21975294 552701 Positive_regulation MAPK14 FAS 21975294 552702 Positive_regulation MAPK14 FAS 21975294 552703 Positive_regulation MAPK14 FAS 21975294 552704 Positive_regulation MAPK14 FAS 21975294 552705 Positive_regulation MAPK14 FAS 21975294 552801 Positive_regulation MAPK14 FAS 21975294 552802 Positive_regulation MAPK14 FAS 21975294 552803 Positive_regulation MAPK14 FAS 21975294 552910 Positive_regulation MAPK14 FAS 21975294 552911 Positive_regulation MAPK14 FAS 21975294 552912 Positive_regulation MAPK14 FAS 21975294 553079 Positive_regulation MAPK14 FAS 23029562 2698771 Positive_regulation MAPK14 FAS 23029562 2698792 Positive_regulation MAPK14 FAS 23852022 1108461 Positive_regulation MAPK14 FAS 25196936 1730931 Positive_regulation MAPK14 FAS 9362518 1464813 Positive_regulation MAPK14 FBXO32 22082477 682643 Positive_regulation MAPK14 FBXO32 23046544 3161238 Positive_regulation MAPK14 FOXO1 20375467 26969 Positive_regulation MAPK14 GLP1R 23536825 2773062 Positive_regulation MAPK14 GPR115 22570668 635425 Positive_regulation MAPK14 GPR132 22570668 635414 Positive_regulation MAPK14 GPR87 22570668 635494 Positive_regulation MAPK14 HBEGF 15817123 1844609 Positive_regulation MAPK14 HBEGF 15817123 1844691 Positive_regulation MAPK14 HBEGF 22259731 1146102 Positive_regulation MAPK14 HBEGF 22792252 2661660 Positive_regulation MAPK14 HBEGF PMC3760629 1606203 Positive_regulation MAPK14 IFI27 11560992 1520882 Positive_regulation MAPK14 ITGB2 21206905 2491112 Positive_regulation MAPK14 ITGB2 23508943 906516 Positive_regulation MAPK14 MAP2K6 10330402 1246238 Positive_regulation MAPK14 MAP2K6 10737387 416991 Positive_regulation MAPK14 MAP2K6 11259103 418453 Positive_regulation MAPK14 MAP2K6 12117640 791081 Positive_regulation MAPK14 MAP2K6 14981092 1306465 Positive_regulation MAPK14 MAP2K6 16048647 3105331 Positive_regulation MAPK14 MAP2K6 17525795 2013998 Positive_regulation MAPK14 MAP2K6 17576777 1546456 Positive_regulation MAPK14 MAP2K6 18955270 810981 Positive_regulation MAPK14 MAP2K6 19159010 1055159 Positive_regulation MAPK14 MAP2K6 19159010 1055377 Positive_regulation MAPK14 MAP2K6 19426550 282546 Positive_regulation MAPK14 MAP2K6 20221403 2442593 Positive_regulation MAPK14 MAP2K6 20463961 2449787 Positive_regulation MAPK14 MAP2K6 20802223 2253140 Positive_regulation MAPK14 MAP2K6 20955562 120555 Positive_regulation MAPK14 MAP2K6 20955562 120655 Positive_regulation MAPK14 MAP2K6 21345249 121652 Positive_regulation MAPK14 MAP2K6 22028883 2564929 Positive_regulation MAPK14 MAP2K6 22159586 600576 Positive_regulation MAPK14 MAP2K6 22245064 613578 Positive_regulation MAPK14 MAP2K6 22359624 2598530 Positive_regulation MAPK14 MAP2K6 22415879 722017 Positive_regulation MAPK14 MAP2K6 22415879 722347 Positive_regulation MAPK14 MAP2K6 22529896 2620579 Positive_regulation MAPK14 MAP2K6 22740774 490712 Positive_regulation MAPK14 MAP2K6 22870983 288769 Positive_regulation MAPK14 MAP2K6 22870983 288908 Positive_regulation MAPK14 MAP2K6 22870983 289017 Positive_regulation MAPK14 MAP2K6 23115639 2711457 Positive_regulation MAPK14 MAP2K6 23166686 2718497 Positive_regulation MAPK14 MAP2K6 23535559 1721166 Positive_regulation MAPK14 MAP2K6 23772401 852515 Positive_regulation MAPK14 MAP2K6 23936348 2830129 Positive_regulation MAPK14 MAP2K6 24566153 1124347 Positive_regulation MAPK14 MAP2K6 24792484 2960473 Positive_regulation MAPK14 MAP2K6 25364728 861779 Positive_regulation MAPK14 MAP2K6 25479605 3032545 Positive_regulation MAPK14 MAP2K6 9700154 1469462 Positive_regulation MAPK14 MIP 19781090 1625740 Positive_regulation MAPK14 MIP 21977329 1082349 Positive_regulation MAPK14 MMP28 18778487 384791 Positive_regulation MAPK14 MMP28 23688423 313920 Positive_regulation MAPK14 MMP28 23688423 314375 Positive_regulation MAPK14 MMP28 23878609 821843 Positive_regulation MAPK14 MMP28 25520932 203098 Positive_regulation MAPK14 MMP7 23688423 313935 Positive_regulation MAPK14 MMP7 23688423 314391 Positive_regulation MAPK14 MMP7 23878609 821859 Positive_regulation MAPK14 MMP7 25520932 203113 Positive_regulation MAPK14 MUC16 17029558 2303065 Positive_regulation MAPK14 MUC16 23694968 3135919 Positive_regulation MAPK14 NGFR 22880054 2673869 Positive_regulation MAPK14 NR2F1 24906407 273650 Positive_regulation MAPK14 OXTR 22190926 1072838 Positive_regulation MAPK14 PLAU 23724131 2799125 Positive_regulation MAPK14 PLAU 23724131 2799387 Positive_regulation MAPK14 PTGER2 25327961 216576 Positive_regulation MAPK14 RCAN1 19124655 1553354 Positive_regulation MAPK14 RCAN1 19124655 1553474 Positive_regulation MAPK14 RGS2 24743392 2955349 Positive_regulation MAPK14 S100B 22276098 2589825 Positive_regulation MAPK14 S100B 23259641 1665766 Positive_regulation MAPK14 S100B 23259641 1665780 Positive_regulation MAPK14 S100B 23259641 1665794 Positive_regulation MAPK14 SCGB3A1 22289642 335847 Positive_regulation MAPK14 SLC6A2 18509476 2389900 Positive_regulation MAPK14 SPHK1 16847102 1331304 Positive_regulation MAPK14 SPHK1 20498849 2451135 Positive_regulation MAPK14 SPHK1 20498849 2451170 Positive_regulation MAPK14 TLR7 19043549 3042393 Positive_regulation MAPK14 TLR7 19043549 3042537 Positive_regulation MAPK14 TLR7 19371402 733961 Positive_regulation MAPK14 TLR7 19685283 495402 Positive_regulation MAPK14 TLR7 20832340 1040236 Positive_regulation MAPK14 TLR7 21633096 1992427 Positive_regulation MAPK14 TLR7 21743791 1028455 Positive_regulation MAPK14 TLR7 21943110 2231357 Positive_regulation MAPK14 TLR7 22110382 1058333 Positive_regulation MAPK14 TLR7 22216226 2584838 Positive_regulation MAPK14 TLR7 22829768 3058399 Positive_regulation MAPK14 TLR7 23202320 3184686 Positive_regulation MAPK14 TLR7 23305364 693990 Positive_regulation MAPK14 TLR7 23521892 3215328 Positive_regulation MAPK14 TLR7 23603814 1962869 Positive_regulation MAPK14 TLR7 23760366 2211922 Positive_regulation MAPK14 TLR7 23840534 2814997 Positive_regulation MAPK14 TLR7 24489933 2916831 Positive_regulation MAPK14 TLR7 24603716 2932071 Positive_regulation MAPK14 TLR7 24772440 189726 Positive_regulation MAPK14 TLR7 24800851 2961044 Positive_regulation MAPK14 TLR7 25177436 646986 Positive_regulation MAPK14 TNF 11015442 1517390 Positive_regulation MAPK14 TNF 11015442 1517423 Positive_regulation MAPK14 TNF 11015442 1517436 Positive_regulation MAPK14 TNF 11015442 1517449 Positive_regulation MAPK14 TNF 14613529 3095426 Positive_regulation MAPK14 TNF 15157285 277602 Positive_regulation MAPK14 TNF 15642133 102183 Positive_regulation MAPK14 TNF 15781582 1535128 Positive_regulation MAPK14 TNF 15841081 425536 Positive_regulation MAPK14 TNF 15841081 425537 Positive_regulation MAPK14 TNF 15841081 425872 Positive_regulation MAPK14 TNF 16100442 1634547 Positive_regulation MAPK14 TNF 16100442 1634632 Positive_regulation MAPK14 TNF 16207331 104243 Positive_regulation MAPK14 TNF 16207331 104281 Positive_regulation MAPK14 TNF 16207331 104282 Positive_regulation MAPK14 TNF 16207331 104326 Positive_regulation MAPK14 TNF 16207331 104327 Positive_regulation MAPK14 TNF 16207331 104355 Positive_regulation MAPK14 TNF 16207342 104519 Positive_regulation MAPK14 TNF 16207342 104571 Positive_regulation MAPK14 TNF 17283208 1544259 Positive_regulation MAPK14 TNF 17342245 810731 Positive_regulation MAPK14 TNF 18096615 2032350 Positive_regulation MAPK14 TNF 18404427 3087186 Positive_regulation MAPK14 TNF 18410682 110442 Positive_regulation MAPK14 TNF 19343193 1746546 Positive_regulation MAPK14 TNF 19442267 1696271 Positive_regulation MAPK14 TNF 19707336 175501 Positive_regulation MAPK14 TNF 19723340 1227349 Positive_regulation MAPK14 TNF 19723340 1227364 Positive_regulation MAPK14 TNF 19723340 1227378 Positive_regulation MAPK14 TNF 20157567 26221 Positive_regulation MAPK14 TNF 20157567 26449 Positive_regulation MAPK14 TNF 20308428 1373862 Positive_regulation MAPK14 TNF 20418897 9889 Positive_regulation MAPK14 TNF 20529221 34778 Positive_regulation MAPK14 TNF 20615213 119639 Positive_regulation MAPK14 TNF 20644550 10423 Positive_regulation MAPK14 TNF 20844314 27776 Positive_regulation MAPK14 TNF 20844314 28239 Positive_regulation MAPK14 TNF 20871620 11949 Positive_regulation MAPK14 TNF 21386087 718536 Positive_regulation MAPK14 TNF 21423395 955233 Positive_regulation MAPK14 TNF 21485745 734912 Positive_regulation MAPK14 TNF 21572963 2520300 Positive_regulation MAPK14 TNF 21837268 1082184 Positive_regulation MAPK14 TNF 21867555 1659579 Positive_regulation MAPK14 TNF 21871121 1659630 Positive_regulation MAPK14 TNF 22082477 682555 Positive_regulation MAPK14 TNF 22194685 3055231 Positive_regulation MAPK14 TNF 22802702 1714258 Positive_regulation MAPK14 TNF 22802702 1714271 Positive_regulation MAPK14 TNF 22802702 1714304 Positive_regulation MAPK14 TNF 22988345 1750561 Positive_regulation MAPK14 TNF 23028407 2219773 Positive_regulation MAPK14 TNF 23071583 2703149 Positive_regulation MAPK14 TNF 23071583 2703170 Positive_regulation MAPK14 TNF 23152905 2716808 Positive_regulation MAPK14 TNF 23190711 1665178 Positive_regulation MAPK14 TNF 23282009 1665855 Positive_regulation MAPK14 TNF 23326019 1751334 Positive_regulation MAPK14 TNF 23331383 1675509 Positive_regulation MAPK14 TNF 23533994 180659 Positive_regulation MAPK14 TNF 23626383 1046755 Positive_regulation MAPK14 TNF 23671702 2792494 Positive_regulation MAPK14 TNF 23688423 314370 Positive_regulation MAPK14 TNF 23690670 1752160 Positive_regulation MAPK14 TNF 23755184 2801839 Positive_regulation MAPK14 TNF 23784308 606116 Positive_regulation MAPK14 TNF 23784308 606136 Positive_regulation MAPK14 TNF 23967215 2834999 Positive_regulation MAPK14 TNF 23977119 2838451 Positive_regulation MAPK14 TNF 24008729 565163 Positive_regulation MAPK14 TNF 24008729 565511 Positive_regulation MAPK14 TNF 24024042 2003212 Positive_regulation MAPK14 TNF 24069158 2851393 Positive_regulation MAPK14 TNF 24069158 2851548 Positive_regulation MAPK14 TNF 24069158 2851549 Positive_regulation MAPK14 TNF 24086560 2854628 Positive_regulation MAPK14 TNF 24101950 2227323 Positive_regulation MAPK14 TNF 24244348 2879497 Positive_regulation MAPK14 TNF 24266983 240390 Positive_regulation MAPK14 TNF 24285913 737681 Positive_regulation MAPK14 TNF 24307884 3155528 Positive_regulation MAPK14 TNF 24377382 3225647 Positive_regulation MAPK14 TNF 24423080 538875 Positive_regulation MAPK14 TNF 24460683 240490 Positive_regulation MAPK14 TNF 24487321 1959840 Positive_regulation MAPK14 TNF 24489443 1757407 Positive_regulation MAPK14 TNF 24502696 1233043 Positive_regulation MAPK14 TNF 24502696 1233066 Positive_regulation MAPK14 TNF 24502696 1233118 Positive_regulation MAPK14 TNF 24502696 1233119 Positive_regulation MAPK14 TNF 24502696 1233163 Positive_regulation MAPK14 TNF 24502696 1233164 Positive_regulation MAPK14 TNF 24502696 1233222 Positive_regulation MAPK14 TNF 24502696 1233268 Positive_regulation MAPK14 TNF 24502696 1233296 Positive_regulation MAPK14 TNF 24587316 2929414 Positive_regulation MAPK14 TNF 24614867 2933185 Positive_regulation MAPK14 TNF 24616552 1757560 Positive_regulation MAPK14 TNF 24707477 188333 Positive_regulation MAPK14 TNF 24707477 188437 Positive_regulation MAPK14 TNF 24707477 188467 Positive_regulation MAPK14 TNF 24758719 1483151 Positive_regulation MAPK14 TNF 24773466 34207 Positive_regulation MAPK14 TNF 24821138 2969099 Positive_regulation MAPK14 TNF 24886088 347470 Positive_regulation MAPK14 TNF 25090227 2995085 Positive_regulation MAPK14 TNF 25110549 2229790 Positive_regulation MAPK14 TNF 25114952 3156816 Positive_regulation MAPK14 TNF 25114952 3156832 Positive_regulation MAPK14 TNF 25152756 826697 Positive_regulation MAPK14 TNF 25196285 3224114 Positive_regulation MAPK14 TNF 25206704 2005727 Positive_regulation MAPK14 TNF 25435878 1074934 Positive_regulation MAPK14 TNF 7525608 1436379 Positive_regulation MAPK14 TNF 7530764 1590000 Positive_regulation MAPK14 TNF 8562342 445249 Positive_regulation MAPK14 TNF 8666946 1597670 Positive_regulation MAPK14 TNFSF10 22462553 1230462 Positive_regulation MAPK14 TNFSF10 22719861 2653322 Positive_regulation MAPK15 ALOX5 22363611 2601197 Positive_regulation MAPK15 ALOX5 25025775 2989407 Positive_regulation MAPK15 ANGPT1 24013716 2842142 Positive_regulation MAPK15 ANGPT1 25329960 3017075 Positive_regulation MAPK15 ARSA 20339548 2444457 Positive_regulation MAPK15 ARSA 20339548 2444485 Positive_regulation MAPK15 CAPN8 24416390 2908293 Positive_regulation MAPK15 CCND1 22220184 1155987 Positive_regulation MAPK15 CCND1 25047753 240825 Positive_regulation MAPK15 CD14 20011115 3045927 Positive_regulation MAPK15 CD14 21387014 2506178 Positive_regulation MAPK15 CD14 24376813 2902203 Positive_regulation MAPK15 CHI3L1 23755018 961356 Positive_regulation MAPK15 CHI3L1 23972995 608979 Positive_regulation MAPK15 CHI3L1 23972995 608980 Positive_regulation MAPK15 CHI3L1 24729664 1758065 Positive_regulation MAPK15 CTGF 22135505 3128237 Positive_regulation MAPK15 CTGF 22918238 541766 Positive_regulation MAPK15 CTGF 23383241 2749631 Positive_regulation MAPK15 CTGF 23946690 1716060 Positive_regulation MAPK15 CYP24A1 22577546 1139572 Positive_regulation MAPK15 EDN2 12369712 1077793 Positive_regulation MAPK15 EDN2 24695532 2948218 Positive_regulation MAPK15 EPHB2 11783444 2001204 Positive_regulation MAPK15 EPHB2 18578886 356850 Positive_regulation MAPK15 EPHB2 19047466 1361936 Positive_regulation MAPK15 EPHB2 19047466 1361937 Positive_regulation MAPK15 EPHB2 19047466 1361938 Positive_regulation MAPK15 EPHB2 19047466 1362078 Positive_regulation MAPK15 EPHB2 19047466 1362079 Positive_regulation MAPK15 EPHB2 19047466 1362118 Positive_regulation MAPK15 EPHB2 19107595 1027476 Positive_regulation MAPK15 EPHB2 19357636 1902934 Positive_regulation MAPK15 EPHB2 20100173 212584 Positive_regulation MAPK15 EPHB2 21488184 3232764 Positive_regulation MAPK15 EPHB2 21488184 3232765 Positive_regulation MAPK15 EPHB2 21876711 813167 Positive_regulation MAPK15 EPHB2 22294469 135316 Positive_regulation MAPK15 EPHB2 22507553 1661673 Positive_regulation MAPK15 EPHB2 22675451 2648308 Positive_regulation MAPK15 EPHB2 22719861 2653310 Positive_regulation MAPK15 EPHB2 22723883 2655007 Positive_regulation MAPK15 EPHB2 22741533 381915 Positive_regulation MAPK15 EPHB2 22951718 1631185 Positive_regulation MAPK15 EPHB2 23383241 2749632 Positive_regulation MAPK15 EPHB2 23388501 1920503 Positive_regulation MAPK15 EPHB2 23738323 181885 Positive_regulation MAPK15 EPHB2 23826208 2811459 Positive_regulation MAPK15 EPHB2 24098984 1726325 Positive_regulation MAPK15 EPHB2 24823621 1624660 Positive_regulation MAPK15 EPHB2 24885161 396500 Positive_regulation MAPK15 EPHB2 24978597 2985577 Positive_regulation MAPK15 EPHB2 25299961 174455 Positive_regulation MAPK15 F2R 21378407 2175452 Positive_regulation MAPK15 F2R 21760880 2535396 Positive_regulation MAPK15 F2R 21760880 2535631 Positive_regulation MAPK15 F2R 21845431 3158093 Positive_regulation MAPK15 F2R 24215724 538251 Positive_regulation MAPK15 F2R 24278684 3150062 Positive_regulation MAPK15 F2R 24743392 2955195 Positive_regulation MAPK15 F2R 24743392 2955327 Positive_regulation MAPK15 F2R 24743392 2955403 Positive_regulation MAPK15 F2R 24860547 880650 Positive_regulation MAPK15 FAS 11259103 418433 Positive_regulation MAPK15 FAS 14970175 1531117 Positive_regulation MAPK15 FAS 19487421 1555050 Positive_regulation MAPK15 FAS 19564926 1055583 Positive_regulation MAPK15 FAS 20573240 1856423 Positive_regulation MAPK15 FAS 20573240 1856449 Positive_regulation MAPK15 FAS 21477291 527138 Positive_regulation MAPK15 FAS 21975294 552664 Positive_regulation MAPK15 FAS 21975294 552665 Positive_regulation MAPK15 FAS 21975294 552666 Positive_regulation MAPK15 FAS 21975294 552667 Positive_regulation MAPK15 FAS 21975294 552668 Positive_regulation MAPK15 FAS 21975294 552669 Positive_regulation MAPK15 FAS 21975294 552783 Positive_regulation MAPK15 FAS 21975294 552784 Positive_regulation MAPK15 FAS 21975294 552785 Positive_regulation MAPK15 FAS 21975294 552874 Positive_regulation MAPK15 FAS 21975294 552875 Positive_regulation MAPK15 FAS 21975294 552876 Positive_regulation MAPK15 FAS 21975294 552995 Positive_regulation MAPK15 FAS 23029562 2698765 Positive_regulation MAPK15 FAS 23029562 2698786 Positive_regulation MAPK15 FAS 23852022 1108455 Positive_regulation MAPK15 FAS 25196936 1730919 Positive_regulation MAPK15 FAS 9362518 1464799 Positive_regulation MAPK15 FBXO32 22082477 682625 Positive_regulation MAPK15 FBXO32 23046544 3161232 Positive_regulation MAPK15 FOXO1 20375467 26921 Positive_regulation MAPK15 GLP1R 23536825 2773056 Positive_regulation MAPK15 GPR115 22570668 634820 Positive_regulation MAPK15 GPR132 22570668 634809 Positive_regulation MAPK15 GPR87 22570668 634889 Positive_regulation MAPK15 HBEGF 15817123 1844552 Positive_regulation MAPK15 HBEGF 15817123 1844630 Positive_regulation MAPK15 HBEGF 22259731 1146096 Positive_regulation MAPK15 HBEGF 22792252 2661654 Positive_regulation MAPK15 HBEGF PMC3760629 1606180 Positive_regulation MAPK15 IFI27 11560992 1520854 Positive_regulation MAPK15 ITGB2 21206905 2491095 Positive_regulation MAPK15 ITGB2 23508943 906504 Positive_regulation MAPK15 MAP2K6 10330402 1246192 Positive_regulation MAPK15 MAP2K6 10737387 416949 Positive_regulation MAPK15 MAP2K6 11259103 418435 Positive_regulation MAPK15 MAP2K6 12117640 791039 Positive_regulation MAPK15 MAP2K6 14981092 1306409 Positive_regulation MAPK15 MAP2K6 16048647 3105198 Positive_regulation MAPK15 MAP2K6 17525795 2013976 Positive_regulation MAPK15 MAP2K6 17576777 1546414 Positive_regulation MAPK15 MAP2K6 18955270 810903 Positive_regulation MAPK15 MAP2K6 19159010 1055153 Positive_regulation MAPK15 MAP2K6 19159010 1055358 Positive_regulation MAPK15 MAP2K6 19426550 282399 Positive_regulation MAPK15 MAP2K6 20221403 2442581 Positive_regulation MAPK15 MAP2K6 20463961 2449775 Positive_regulation MAPK15 MAP2K6 20802223 2253132 Positive_regulation MAPK15 MAP2K6 20955562 120531 Positive_regulation MAPK15 MAP2K6 20955562 120639 Positive_regulation MAPK15 MAP2K6 21345249 121610 Positive_regulation MAPK15 MAP2K6 22028883 2564796 Positive_regulation MAPK15 MAP2K6 22159586 600514 Positive_regulation MAPK15 MAP2K6 22245064 613535 Positive_regulation MAPK15 MAP2K6 22359624 2598469 Positive_regulation MAPK15 MAP2K6 22415879 721974 Positive_regulation MAPK15 MAP2K6 22415879 722317 Positive_regulation MAPK15 MAP2K6 22529896 2620537 Positive_regulation MAPK15 MAP2K6 22740774 490670 Positive_regulation MAPK15 MAP2K6 22870983 288749 Positive_regulation MAPK15 MAP2K6 22870983 288874 Positive_regulation MAPK15 MAP2K6 22870983 288984 Positive_regulation MAPK15 MAP2K6 23115639 2711445 Positive_regulation MAPK15 MAP2K6 23166686 2718455 Positive_regulation MAPK15 MAP2K6 23535559 1721110 Positive_regulation MAPK15 MAP2K6 23772401 852268 Positive_regulation MAPK15 MAP2K6 23936348 2829996 Positive_regulation MAPK15 MAP2K6 24566153 1124305 Positive_regulation MAPK15 MAP2K6 24792484 2960431 Positive_regulation MAPK15 MAP2K6 25364728 861754 Positive_regulation MAPK15 MAP2K6 25479605 3032496 Positive_regulation MAPK15 MAP2K6 9700154 1469420 Positive_regulation MAPK15 MIP 19781090 1625706 Positive_regulation MAPK15 MIP 21977329 1082343 Positive_regulation MAPK15 MMP28 18778487 384785 Positive_regulation MAPK15 MMP28 23688423 313764 Positive_regulation MAPK15 MMP28 23688423 314231 Positive_regulation MAPK15 MMP28 23878609 821705 Positive_regulation MAPK15 MMP28 25520932 202966 Positive_regulation MAPK15 MMP7 23688423 313779 Positive_regulation MAPK15 MMP7 23688423 314247 Positive_regulation MAPK15 MMP7 23878609 821721 Positive_regulation MAPK15 MMP7 25520932 202981 Positive_regulation MAPK15 MUC16 17029558 2302955 Positive_regulation MAPK15 MUC16 23694968 3135900 Positive_regulation MAPK15 NGFR 22880054 2673845 Positive_regulation MAPK15 NR2F1 24906407 273644 Positive_regulation MAPK15 OXTR 22190926 1072832 Positive_regulation MAPK15 PLAU 23724131 2799113 Positive_regulation MAPK15 PLAU 23724131 2799377 Positive_regulation MAPK15 PTGER2 25327961 216570 Positive_regulation MAPK15 RCAN1 19124655 1553338 Positive_regulation MAPK15 RCAN1 19124655 1553467 Positive_regulation MAPK15 RGS2 24743392 2955328 Positive_regulation MAPK15 S100B 22276098 2589812 Positive_regulation MAPK15 S100B 23259641 1665760 Positive_regulation MAPK15 S100B 23259641 1665774 Positive_regulation MAPK15 S100B 23259641 1665788 Positive_regulation MAPK15 SCGB3A1 22289642 335841 Positive_regulation MAPK15 SLC6A2 18509476 2389892 Positive_regulation MAPK15 SPHK1 16847102 1331290 Positive_regulation MAPK15 SPHK1 20498849 2451129 Positive_regulation MAPK15 SPHK1 20498849 2451164 Positive_regulation MAPK15 TLR7 19043549 3042333 Positive_regulation MAPK15 TLR7 19043549 3042477 Positive_regulation MAPK15 TLR7 19371402 733901 Positive_regulation MAPK15 TLR7 19685283 495342 Positive_regulation MAPK15 TLR7 20832340 1040223 Positive_regulation MAPK15 TLR7 21633096 1992277 Positive_regulation MAPK15 TLR7 21743791 1028393 Positive_regulation MAPK15 TLR7 21943110 2231297 Positive_regulation MAPK15 TLR7 22110382 1058263 Positive_regulation MAPK15 TLR7 22216226 2584778 Positive_regulation MAPK15 TLR7 22829768 3058338 Positive_regulation MAPK15 TLR7 23202320 3184613 Positive_regulation MAPK15 TLR7 23305364 693919 Positive_regulation MAPK15 TLR7 23521892 3215268 Positive_regulation MAPK15 TLR7 23603814 1962774 Positive_regulation MAPK15 TLR7 23760366 2211832 Positive_regulation MAPK15 TLR7 23840534 2814937 Positive_regulation MAPK15 TLR7 24489933 2916769 Positive_regulation MAPK15 TLR7 24603716 2932011 Positive_regulation MAPK15 TLR7 24772440 189666 Positive_regulation MAPK15 TLR7 24800851 2960984 Positive_regulation MAPK15 TLR7 25177436 646926 Positive_regulation MAPK15 TNF 11015442 1517378 Positive_regulation MAPK15 TNF 11015442 1517417 Positive_regulation MAPK15 TNF 11015442 1517430 Positive_regulation MAPK15 TNF 11015442 1517443 Positive_regulation MAPK15 TNF 14613529 3095420 Positive_regulation MAPK15 TNF 15157285 277596 Positive_regulation MAPK15 TNF 15642133 102171 Positive_regulation MAPK15 TNF 15781582 1535122 Positive_regulation MAPK15 TNF 15841081 425522 Positive_regulation MAPK15 TNF 15841081 425523 Positive_regulation MAPK15 TNF 15841081 425524 Positive_regulation MAPK15 TNF 15841081 425859 Positive_regulation MAPK15 TNF 16100442 1634474 Positive_regulation MAPK15 TNF 16100442 1634626 Positive_regulation MAPK15 TNF 16207331 104236 Positive_regulation MAPK15 TNF 16207331 104269 Positive_regulation MAPK15 TNF 16207331 104270 Positive_regulation MAPK15 TNF 16207331 104308 Positive_regulation MAPK15 TNF 16207331 104309 Positive_regulation MAPK15 TNF 16207331 104349 Positive_regulation MAPK15 TNF 16207342 104513 Positive_regulation MAPK15 TNF 16207342 104565 Positive_regulation MAPK15 TNF 17283208 1544253 Positive_regulation MAPK15 TNF 17342245 810725 Positive_regulation MAPK15 TNF 18096615 2032336 Positive_regulation MAPK15 TNF 18404427 3087180 Positive_regulation MAPK15 TNF 18410682 110430 Positive_regulation MAPK15 TNF 19343193 1746540 Positive_regulation MAPK15 TNF 19442267 1696265 Positive_regulation MAPK15 TNF 19707336 175487 Positive_regulation MAPK15 TNF 19723340 1227342 Positive_regulation MAPK15 TNF 19723340 1227358 Positive_regulation MAPK15 TNF 19723340 1227372 Positive_regulation MAPK15 TNF 20157567 26190 Positive_regulation MAPK15 TNF 20157567 26443 Positive_regulation MAPK15 TNF 20308428 1373856 Positive_regulation MAPK15 TNF 20418897 9878 Positive_regulation MAPK15 TNF 20529221 34772 Positive_regulation MAPK15 TNF 20615213 119590 Positive_regulation MAPK15 TNF 20644550 10417 Positive_regulation MAPK15 TNF 20844314 27770 Positive_regulation MAPK15 TNF 20844314 28232 Positive_regulation MAPK15 TNF 20871620 11943 Positive_regulation MAPK15 TNF 21386087 718422 Positive_regulation MAPK15 TNF 21423395 955221 Positive_regulation MAPK15 TNF 21485745 734887 Positive_regulation MAPK15 TNF 21572963 2520294 Positive_regulation MAPK15 TNF 21837268 1082177 Positive_regulation MAPK15 TNF 21867555 1659573 Positive_regulation MAPK15 TNF 21871121 1659624 Positive_regulation MAPK15 TNF 22082477 682543 Positive_regulation MAPK15 TNF 22194685 3055225 Positive_regulation MAPK15 TNF 22802702 1714252 Positive_regulation MAPK15 TNF 22802702 1714265 Positive_regulation MAPK15 TNF 22802702 1714298 Positive_regulation MAPK15 TNF 22988345 1750555 Positive_regulation MAPK15 TNF 23028407 2219739 Positive_regulation MAPK15 TNF 23071583 2703142 Positive_regulation MAPK15 TNF 23071583 2703164 Positive_regulation MAPK15 TNF 23152905 2716802 Positive_regulation MAPK15 TNF 23190711 1665172 Positive_regulation MAPK15 TNF 23282009 1665849 Positive_regulation MAPK15 TNF 23326019 1751327 Positive_regulation MAPK15 TNF 23331383 1675479 Positive_regulation MAPK15 TNF 23533994 180653 Positive_regulation MAPK15 TNF 23626383 1046741 Positive_regulation MAPK15 TNF 23671702 2792485 Positive_regulation MAPK15 TNF 23688423 314226 Positive_regulation MAPK15 TNF 23690670 1752148 Positive_regulation MAPK15 TNF 23755184 2801833 Positive_regulation MAPK15 TNF 23784308 606108 Positive_regulation MAPK15 TNF 23784308 606124 Positive_regulation MAPK15 TNF 23967215 2834981 Positive_regulation MAPK15 TNF 23977119 2838445 Positive_regulation MAPK15 TNF 24008729 565096 Positive_regulation MAPK15 TNF 24008729 565505 Positive_regulation MAPK15 TNF 24024042 2003206 Positive_regulation MAPK15 TNF 24069158 2851359 Positive_regulation MAPK15 TNF 24069158 2851534 Positive_regulation MAPK15 TNF 24069158 2851535 Positive_regulation MAPK15 TNF 24086560 2854622 Positive_regulation MAPK15 TNF 24101950 2227289 Positive_regulation MAPK15 TNF 24244348 2879491 Positive_regulation MAPK15 TNF 24266983 240384 Positive_regulation MAPK15 TNF 24285913 737675 Positive_regulation MAPK15 TNF 24307884 3155522 Positive_regulation MAPK15 TNF 24377382 3225641 Positive_regulation MAPK15 TNF 24423080 538868 Positive_regulation MAPK15 TNF 24460683 240484 Positive_regulation MAPK15 TNF 24487321 1959831 Positive_regulation MAPK15 TNF 24489443 1757397 Positive_regulation MAPK15 TNF 24502696 1233037 Positive_regulation MAPK15 TNF 24502696 1233060 Positive_regulation MAPK15 TNF 24502696 1233106 Positive_regulation MAPK15 TNF 24502696 1233107 Positive_regulation MAPK15 TNF 24502696 1233149 Positive_regulation MAPK15 TNF 24502696 1233150 Positive_regulation MAPK15 TNF 24502696 1233216 Positive_regulation MAPK15 TNF 24502696 1233253 Positive_regulation MAPK15 TNF 24502696 1233290 Positive_regulation MAPK15 TNF 24587316 2929408 Positive_regulation MAPK15 TNF 24614867 2933179 Positive_regulation MAPK15 TNF 24616552 1757554 Positive_regulation MAPK15 TNF 24707477 188302 Positive_regulation MAPK15 TNF 24707477 188430 Positive_regulation MAPK15 TNF 24707477 188459 Positive_regulation MAPK15 TNF 24758719 1483141 Positive_regulation MAPK15 TNF 24773466 34201 Positive_regulation MAPK15 TNF 24821138 2969093 Positive_regulation MAPK15 TNF 24886088 347464 Positive_regulation MAPK15 TNF 25090227 2995079 Positive_regulation MAPK15 TNF 25110549 2229784 Positive_regulation MAPK15 TNF 25114952 3156810 Positive_regulation MAPK15 TNF 25114952 3156823 Positive_regulation MAPK15 TNF 25152756 826685 Positive_regulation MAPK15 TNF 25196285 3224107 Positive_regulation MAPK15 TNF 25206704 2005721 Positive_regulation MAPK15 TNF 25435878 1074928 Positive_regulation MAPK15 TNF 7525608 1436373 Positive_regulation MAPK15 TNF 7530764 1589994 Positive_regulation MAPK15 TNF 8562342 445243 Positive_regulation MAPK15 TNF 8666946 1597664 Positive_regulation MAPK15 TNFSF10 22462553 1230456 Positive_regulation MAPK15 TNFSF10 22719861 2653309 Positive_regulation MAPK3 ABCA4 23805043 1915995 Positive_regulation MAPK3 ALOX5 22363611 2601205 Positive_regulation MAPK3 ALOX5 25025775 2989415 Positive_regulation MAPK3 ANGPT1 17341311 279534 Positive_regulation MAPK3 ANGPT1 17341311 279535 Positive_regulation MAPK3 ANGPT1 17341311 279540 Positive_regulation MAPK3 ANGPT1 17341311 279553 Positive_regulation MAPK3 ANGPT1 17341311 279563 Positive_regulation MAPK3 ANGPT1 21795402 1793238 Positive_regulation MAPK3 ANGPT1 22187650 1145444 Positive_regulation MAPK3 ANGPT1 22792187 2661151 Positive_regulation MAPK3 ANGPT1 22792187 2661204 Positive_regulation MAPK3 ANGPT1 22792187 2661205 Positive_regulation MAPK3 ANGPT1 24013716 2842153 Positive_regulation MAPK3 ANGPT1 24308939 1158488 Positive_regulation MAPK3 ANGPT1 25329960 3017105 Positive_regulation MAPK3 ANO1 22912841 2679580 Positive_regulation MAPK3 ARSA 20339548 2444464 Positive_regulation MAPK3 ARSA 20339548 2444492 Positive_regulation MAPK3 ARSA 20640495 511702 Positive_regulation MAPK3 ARSA 22761875 2658995 Positive_regulation MAPK3 ARSA 22761875 2658996 Positive_regulation MAPK3 ARSA 22761875 2658997 Positive_regulation MAPK3 ARSA 22761875 2658998 Positive_regulation MAPK3 ARSA 22761875 2658999 Positive_regulation MAPK3 ARSA 22761875 2659007 Positive_regulation MAPK3 ARSA 22761875 2659008 Positive_regulation MAPK3 ARSA 22761875 2659009 Positive_regulation MAPK3 ARSA 22761875 2659018 Positive_regulation MAPK3 ARSA 22761875 2659024 Positive_regulation MAPK3 ARSA 22761875 2659025 Positive_regulation MAPK3 ARSA 22761875 2659032 Positive_regulation MAPK3 ARSA 22761875 2659033 Positive_regulation MAPK3 ARSA 22761875 2659042 Positive_regulation MAPK3 ARSA 22761875 2659046 Positive_regulation MAPK3 ARSA 22761875 2659049 Positive_regulation MAPK3 CAPN8 24416390 2908391 Positive_regulation MAPK3 CCND1 22220184 1155997 Positive_regulation MAPK3 CCND1 25047753 240929 Positive_regulation MAPK3 CCND1 25093037 1650927 Positive_regulation MAPK3 CD14 20011115 3045934 Positive_regulation MAPK3 CD14 20150966 1213532 Positive_regulation MAPK3 CD14 21387014 2506187 Positive_regulation MAPK3 CD14 24376813 2902229 Positive_regulation MAPK3 CEACAM6 22905257 2675871 Positive_regulation MAPK3 CHI3L1 22211103 1058702 Positive_regulation MAPK3 CHI3L1 22211103 1058703 Positive_regulation MAPK3 CHI3L1 22211103 1058710 Positive_regulation MAPK3 CHI3L1 23755018 961350 Positive_regulation MAPK3 CHI3L1 23755018 961380 Positive_regulation MAPK3 CHI3L1 23972995 608999 Positive_regulation MAPK3 CHI3L1 23972995 609000 Positive_regulation MAPK3 CHI3L1 24729664 1758072 Positive_regulation MAPK3 CTGF 19922639 117858 Positive_regulation MAPK3 CTGF 19922639 117864 Positive_regulation MAPK3 CTGF 21760921 2535986 Positive_regulation MAPK3 CTGF 21760921 2535987 Positive_regulation MAPK3 CTGF 21760921 2535995 Positive_regulation MAPK3 CTGF 21760921 2536001 Positive_regulation MAPK3 CTGF 21760921 2536011 Positive_regulation MAPK3 CTGF 21760921 2536014 Positive_regulation MAPK3 CTGF 22135505 3128249 Positive_regulation MAPK3 CTGF 22586581 722790 Positive_regulation MAPK3 CTGF 22918238 541775 Positive_regulation MAPK3 CTGF 23259759 856345 Positive_regulation MAPK3 CTGF 23383241 2749647 Positive_regulation MAPK3 CTGF 23946690 1716068 Positive_regulation MAPK3 CTGF 24090133 537715 Positive_regulation MAPK3 CTGF 24090133 537718 Positive_regulation MAPK3 CTGF 24551846 187114 Positive_regulation MAPK3 CTGF 25514242 1135699 Positive_regulation MAPK3 CYP24A1 22577546 1139592 Positive_regulation MAPK3 DAPK1 23880846 1108919 Positive_regulation MAPK3 EDN2 12369712 1077815 Positive_regulation MAPK3 EDN2 24695532 2948239 Positive_regulation MAPK3 EPHB2 11783444 2001213 Positive_regulation MAPK3 EPHB2 18578886 356870 Positive_regulation MAPK3 EPHB2 19047466 1361975 Positive_regulation MAPK3 EPHB2 19047466 1361976 Positive_regulation MAPK3 EPHB2 19047466 1361977 Positive_regulation MAPK3 EPHB2 19047466 1362105 Positive_regulation MAPK3 EPHB2 19047466 1362106 Positive_regulation MAPK3 EPHB2 19047466 1362138 Positive_regulation MAPK3 EPHB2 19107595 1027492 Positive_regulation MAPK3 EPHB2 19272185 1227046 Positive_regulation MAPK3 EPHB2 19357636 1902962 Positive_regulation MAPK3 EPHB2 20100173 212591 Positive_regulation MAPK3 EPHB2 20559500 1090239 Positive_regulation MAPK3 EPHB2 20939017 1237855 Positive_regulation MAPK3 EPHB2 21488184 3232792 Positive_regulation MAPK3 EPHB2 21488184 3232793 Positive_regulation MAPK3 EPHB2 21876711 813187 Positive_regulation MAPK3 EPHB2 21918620 20696 Positive_regulation MAPK3 EPHB2 22294469 135337 Positive_regulation MAPK3 EPHB2 22507553 1661729 Positive_regulation MAPK3 EPHB2 22675451 2648343 Positive_regulation MAPK3 EPHB2 22719861 2653325 Positive_regulation MAPK3 EPHB2 22723883 2655014 Positive_regulation MAPK3 EPHB2 22741533 381929 Positive_regulation MAPK3 EPHB2 22951718 1631193 Positive_regulation MAPK3 EPHB2 23150750 2225144 Positive_regulation MAPK3 EPHB2 23383241 2749648 Positive_regulation MAPK3 EPHB2 23388501 1920511 Positive_regulation MAPK3 EPHB2 23738323 181929 Positive_regulation MAPK3 EPHB2 23826208 2811466 Positive_regulation MAPK3 EPHB2 24098984 1726345 Positive_regulation MAPK3 EPHB2 24586933 2928423 Positive_regulation MAPK3 EPHB2 24823621 1624668 Positive_regulation MAPK3 EPHB2 24885161 396507 Positive_regulation MAPK3 EPHB2 24978597 2985608 Positive_regulation MAPK3 EPHB2 25299961 174475 Positive_regulation MAPK3 EPHB2 25496490 3115151 Positive_regulation MAPK3 F2R 15940829 2001639 Positive_regulation MAPK3 F2R 21029417 354121 Positive_regulation MAPK3 F2R 21378407 2175459 Positive_regulation MAPK3 F2R 21760880 2535515 Positive_regulation MAPK3 F2R 21760880 2535777 Positive_regulation MAPK3 F2R 21760880 2535859 Positive_regulation MAPK3 F2R 21845431 3158100 Positive_regulation MAPK3 F2R 22482044 661415 Positive_regulation MAPK3 F2R 24215724 538276 Positive_regulation MAPK3 F2R 24278684 3150069 Positive_regulation MAPK3 F2R 24743392 2955219 Positive_regulation MAPK3 F2R 24743392 2955351 Positive_regulation MAPK3 F2R 24743392 2955413 Positive_regulation MAPK3 F2R 24743392 2955414 Positive_regulation MAPK3 F2R 24860547 880685 Positive_regulation MAPK3 F2R 25002860 880771 Positive_regulation MAPK3 F2R 25364818 3021834 Positive_regulation MAPK3 F2R 25364818 3021836 Positive_regulation MAPK3 FAS 11259103 418454 Positive_regulation MAPK3 FAS 14970175 1531124 Positive_regulation MAPK3 FAS 19487421 1555064 Positive_regulation MAPK3 FAS 19564926 1055590 Positive_regulation MAPK3 FAS 20573240 1856430 Positive_regulation MAPK3 FAS 20573240 1856456 Positive_regulation MAPK3 FAS 21477291 527145 Positive_regulation MAPK3 FAS 21975294 552706 Positive_regulation MAPK3 FAS 21975294 552707 Positive_regulation MAPK3 FAS 21975294 552708 Positive_regulation MAPK3 FAS 21975294 552709 Positive_regulation MAPK3 FAS 21975294 552710 Positive_regulation MAPK3 FAS 21975294 552711 Positive_regulation MAPK3 FAS 21975294 552804 Positive_regulation MAPK3 FAS 21975294 552805 Positive_regulation MAPK3 FAS 21975294 552806 Positive_regulation MAPK3 FAS 21975294 552916 Positive_regulation MAPK3 FAS 21975294 552917 Positive_regulation MAPK3 FAS 21975294 552918 Positive_regulation MAPK3 FAS 21975294 552994 Positive_regulation MAPK3 FAS 21975294 553093 Positive_regulation MAPK3 FAS 21975294 553181 Positive_regulation MAPK3 FAS 23029562 2698772 Positive_regulation MAPK3 FAS 23029562 2698793 Positive_regulation MAPK3 FAS 23852022 1108462 Positive_regulation MAPK3 FAS 25196936 1730933 Positive_regulation MAPK3 FAS 9362518 1464815 Positive_regulation MAPK3 FAS 9396757 1465256 Positive_regulation MAPK3 FBXO32 22082477 682646 Positive_regulation MAPK3 FBXO32 23046544 3161239 Positive_regulation MAPK3 FOXO1 20375467 26973 Positive_regulation MAPK3 GLP1R 23536825 2773063 Positive_regulation MAPK3 GPNMB 22891158 3131108 Positive_regulation MAPK3 GPR115 18777108 3090424 Positive_regulation MAPK3 GPR115 22570668 635518 Positive_regulation MAPK3 GPR115 24528626 511204 Positive_regulation MAPK3 GPR132 18777108 3090413 Positive_regulation MAPK3 GPR132 22570668 635507 Positive_regulation MAPK3 GPR132 24528626 511193 Positive_regulation MAPK3 GPR87 18777108 3090493 Positive_regulation MAPK3 GPR87 22570668 635587 Positive_regulation MAPK3 GPR87 24528626 511273 Positive_regulation MAPK3 HBEGF 15817123 1844612 Positive_regulation MAPK3 HBEGF 15817123 1844693 Positive_regulation MAPK3 HBEGF 22259731 1146103 Positive_regulation MAPK3 HBEGF 22792252 2661661 Positive_regulation MAPK3 HBEGF 22984591 2689348 Positive_regulation MAPK3 HBEGF PMC3760629 1606204 Positive_regulation MAPK3 ID1 18489764 352167 Positive_regulation MAPK3 IFI27 11560992 1520884 Positive_regulation MAPK3 ITGB2 21206905 2491114 Positive_regulation MAPK3 ITGB2 21850266 2542743 Positive_regulation MAPK3 ITGB2 23508943 906518 Positive_regulation MAPK3 LBP 20150966 1213533 Positive_regulation MAPK3 MAP2K6 10330402 1246240 Positive_regulation MAPK3 MAP2K6 10477763 1249237 Positive_regulation MAPK3 MAP2K6 10737387 416998 Positive_regulation MAPK3 MAP2K6 10769028 1257139 Positive_regulation MAPK3 MAP2K6 11259103 418456 Positive_regulation MAPK3 MAP2K6 12117640 791088 Positive_regulation MAPK3 MAP2K6 14981092 1306473 Positive_regulation MAPK3 MAP2K6 15123736 1308409 Positive_regulation MAPK3 MAP2K6 15353558 1533378 Positive_regulation MAPK3 MAP2K6 15946381 3105054 Positive_regulation MAPK3 MAP2K6 15946381 3105072 Positive_regulation MAPK3 MAP2K6 16048647 3105338 Positive_regulation MAPK3 MAP2K6 16103225 1323181 Positive_regulation MAPK3 MAP2K6 17391532 3107968 Positive_regulation MAPK3 MAP2K6 17525795 2013999 Positive_regulation MAPK3 MAP2K6 17576777 1546463 Positive_regulation MAPK3 MAP2K6 18194572 401181 Positive_regulation MAPK3 MAP2K6 18662930 90764 Positive_regulation MAPK3 MAP2K6 18777108 3090275 Positive_regulation MAPK3 MAP2K6 18949068 2208040 Positive_regulation MAPK3 MAP2K6 18955270 810994 Positive_regulation MAPK3 MAP2K6 19159010 1055160 Positive_regulation MAPK3 MAP2K6 19159010 1055378 Positive_regulation MAPK3 MAP2K6 19426550 282553 Positive_regulation MAPK3 MAP2K6 19575782 283041 Positive_regulation MAPK3 MAP2K6 19575782 283114 Positive_regulation MAPK3 MAP2K6 19668516 649419 Positive_regulation MAPK3 MAP2K6 19808894 711280 Positive_regulation MAPK3 MAP2K6 20181831 1774741 Positive_regulation MAPK3 MAP2K6 20221403 2442595 Positive_regulation MAPK3 MAP2K6 20463961 2449789 Positive_regulation MAPK3 MAP2K6 20802223 2253141 Positive_regulation MAPK3 MAP2K6 20955562 120559 Positive_regulation MAPK3 MAP2K6 20955562 120657 Positive_regulation MAPK3 MAP2K6 21345249 121659 Positive_regulation MAPK3 MAP2K6 21699731 1862562 Positive_regulation MAPK3 MAP2K6 21833779 3337 Positive_regulation MAPK3 MAP2K6 22028883 2564936 Positive_regulation MAPK3 MAP2K6 22069624 3182823 Positive_regulation MAPK3 MAP2K6 22159586 600583 Positive_regulation MAPK3 MAP2K6 22188922 291864 Positive_regulation MAPK3 MAP2K6 22245064 613585 Positive_regulation MAPK3 MAP2K6 22254061 2116064 Positive_regulation MAPK3 MAP2K6 22299051 2594256 Positive_regulation MAPK3 MAP2K6 22315658 1702868 Positive_regulation MAPK3 MAP2K6 22359624 2598538 Positive_regulation MAPK3 MAP2K6 22363435 2599019 Positive_regulation MAPK3 MAP2K6 22415879 722022 Positive_regulation MAPK3 MAP2K6 22415879 722352 Positive_regulation MAPK3 MAP2K6 22529896 2620586 Positive_regulation MAPK3 MAP2K6 22606284 2642706 Positive_regulation MAPK3 MAP2K6 22649371 874818 Positive_regulation MAPK3 MAP2K6 22740774 490719 Positive_regulation MAPK3 MAP2K6 22761768 2658254 Positive_regulation MAPK3 MAP2K6 22844495 2668382 Positive_regulation MAPK3 MAP2K6 22870983 288770 Positive_regulation MAPK3 MAP2K6 22870983 288909 Positive_regulation MAPK3 MAP2K6 22870983 289018 Positive_regulation MAPK3 MAP2K6 22880008 2673535 Positive_regulation MAPK3 MAP2K6 22942754 1097361 Positive_regulation MAPK3 MAP2K6 23115639 2711459 Positive_regulation MAPK3 MAP2K6 23133538 2712896 Positive_regulation MAPK3 MAP2K6 23166686 2718504 Positive_regulation MAPK3 MAP2K6 23166699 2718601 Positive_regulation MAPK3 MAP2K6 23311607 482736 Positive_regulation MAPK3 MAP2K6 23535559 1721175 Positive_regulation MAPK3 MAP2K6 23675062 1064429 Positive_regulation MAPK3 MAP2K6 23772401 852554 Positive_regulation MAPK3 MAP2K6 23907465 564606 Positive_regulation MAPK3 MAP2K6 23936348 2830136 Positive_regulation MAPK3 MAP2K6 24030148 566058 Positive_regulation MAPK3 MAP2K6 24116218 2865809 Positive_regulation MAPK3 MAP2K6 24216994 500819 Positive_regulation MAPK3 MAP2K6 24566153 1124354 Positive_regulation MAPK3 MAP2K6 24586913 2928395 Positive_regulation MAPK3 MAP2K6 24753814 206196 Positive_regulation MAPK3 MAP2K6 24792484 2960480 Positive_regulation MAPK3 MAP2K6 24853429 576321 Positive_regulation MAPK3 MAP2K6 24928904 1488000 Positive_regulation MAPK3 MAP2K6 25250333 200019 Positive_regulation MAPK3 MAP2K6 25330306 3017438 Positive_regulation MAPK3 MAP2K6 25330306 3017459 Positive_regulation MAPK3 MAP2K6 25330306 3017466 Positive_regulation MAPK3 MAP2K6 25364728 861781 Positive_regulation MAPK3 MAP2K6 25479605 3032552 Positive_regulation MAPK3 MAP2K6 9700154 1469469 Positive_regulation MAPK3 MIP 17233909 351817 Positive_regulation MAPK3 MIP 19781090 1625741 Positive_regulation MAPK3 MIP 21977329 1082350 Positive_regulation MAPK3 MMP28 18778487 384792 Positive_regulation MAPK3 MMP28 20139904 9380 Positive_regulation MAPK3 MMP28 20667128 1857694 Positive_regulation MAPK3 MMP28 22860018 2671002 Positive_regulation MAPK3 MMP28 23212463 616778 Positive_regulation MAPK3 MMP28 23231703 267217 Positive_regulation MAPK3 MMP28 23688423 313942 Positive_regulation MAPK3 MMP28 23688423 314399 Positive_regulation MAPK3 MMP28 23878609 821866 Positive_regulation MAPK3 MMP28 25520932 203120 Positive_regulation MAPK3 MMP7 20139904 9396 Positive_regulation MAPK3 MMP7 20667128 1857709 Positive_regulation MAPK3 MMP7 22860018 2671017 Positive_regulation MAPK3 MMP7 23212463 616794 Positive_regulation MAPK3 MMP7 23231703 267232 Positive_regulation MAPK3 MMP7 23688423 313957 Positive_regulation MAPK3 MMP7 23688423 314415 Positive_regulation MAPK3 MMP7 23878609 821882 Positive_regulation MAPK3 MMP7 25520932 203135 Positive_regulation MAPK3 MUC16 17029558 2303081 Positive_regulation MAPK3 MUC16 23694968 3135922 Positive_regulation MAPK3 NES 21682918 1862510 Positive_regulation MAPK3 NGFR 22880054 2673871 Positive_regulation MAPK3 NGFR 25243118 199116 Positive_regulation MAPK3 NR2F1 24906407 273651 Positive_regulation MAPK3 OXTR 22190926 1072839 Positive_regulation MAPK3 PLAU 10402467 1248039 Positive_regulation MAPK3 PLAU 10402467 1248049 Positive_regulation MAPK3 PLAU 10402467 1248057 Positive_regulation MAPK3 PLAU 10402467 1248061 Positive_regulation MAPK3 PLAU 17548516 1341112 Positive_regulation MAPK3 PLAU 17548516 1341118 Positive_regulation MAPK3 PLAU 23724131 2799127 Positive_regulation MAPK3 PLAU 23724131 2799388 Positive_regulation MAPK3 PLAU 24073010 822976 Positive_regulation MAPK3 PLAU 24073010 822985 Positive_regulation MAPK3 PLAU 24481457 571866 Positive_regulation MAPK3 PPBP 20652010 1672288 Positive_regulation MAPK3 PTGER2 19782748 613152 Positive_regulation MAPK3 PTGER2 20705717 1885483 Positive_regulation MAPK3 PTGER2 25327961 216577 Positive_regulation MAPK3 RCAN1 19124655 1553355 Positive_regulation MAPK3 RCAN1 19124655 1553475 Positive_regulation MAPK3 RGS2 24743392 2955352 Positive_regulation MAPK3 S100A7 19159013 2404525 Positive_regulation MAPK3 S100B 22227007 2008242 Positive_regulation MAPK3 S100B 22276098 2589827 Positive_regulation MAPK3 S100B 23164356 1895673 Positive_regulation MAPK3 S100B 23164356 1895683 Positive_regulation MAPK3 S100B 23164356 1895684 Positive_regulation MAPK3 S100B 23164356 1895685 Positive_regulation MAPK3 S100B 23259641 1665767 Positive_regulation MAPK3 S100B 23259641 1665781 Positive_regulation MAPK3 S100B 23259641 1665795 Positive_regulation MAPK3 SCGB3A1 22289642 335848 Positive_regulation MAPK3 SLC6A2 18509476 2389901 Positive_regulation MAPK3 SPHK1 16847102 1331306 Positive_regulation MAPK3 SPHK1 20498849 2451136 Positive_regulation MAPK3 SPHK1 20498849 2451171 Positive_regulation MAPK3 SPHK1 25245676 2201753 Positive_regulation MAPK3 SPHK1 25245676 2201754 Positive_regulation MAPK3 TLR7 17371930 1544910 Positive_regulation MAPK3 TLR7 19043549 3042403 Positive_regulation MAPK3 TLR7 19043549 3042547 Positive_regulation MAPK3 TLR7 19371402 733971 Positive_regulation MAPK3 TLR7 19685283 495412 Positive_regulation MAPK3 TLR7 20832340 1040237 Positive_regulation MAPK3 TLR7 21488180 3232648 Positive_regulation MAPK3 TLR7 21633096 1992437 Positive_regulation MAPK3 TLR7 21743791 1028465 Positive_regulation MAPK3 TLR7 21943110 2231367 Positive_regulation MAPK3 TLR7 22091401 1831086 Positive_regulation MAPK3 TLR7 22110382 1058343 Positive_regulation MAPK3 TLR7 22216226 2584848 Positive_regulation MAPK3 TLR7 22829768 3058409 Positive_regulation MAPK3 TLR7 23202320 3184697 Positive_regulation MAPK3 TLR7 23305364 694000 Positive_regulation MAPK3 TLR7 23521892 3215338 Positive_regulation MAPK3 TLR7 23527104 2769469 Positive_regulation MAPK3 TLR7 23527104 2769499 Positive_regulation MAPK3 TLR7 23603814 1962881 Positive_regulation MAPK3 TLR7 23760366 2211932 Positive_regulation MAPK3 TLR7 23840534 2815007 Positive_regulation MAPK3 TLR7 24489933 2916841 Positive_regulation MAPK3 TLR7 24603716 2932081 Positive_regulation MAPK3 TLR7 24725889 1483051 Positive_regulation MAPK3 TLR7 24772440 189736 Positive_regulation MAPK3 TLR7 24800851 2961054 Positive_regulation MAPK3 TLR7 25177436 646996 Positive_regulation MAPK3 TLR7 25351958 153517 Positive_regulation MAPK3 TNF 11015442 1517392 Positive_regulation MAPK3 TNF 11015442 1517424 Positive_regulation MAPK3 TNF 11015442 1517437 Positive_regulation MAPK3 TNF 11015442 1517450 Positive_regulation MAPK3 TNF 14577832 3095123 Positive_regulation MAPK3 TNF 14577832 3095124 Positive_regulation MAPK3 TNF 14613529 3095427 Positive_regulation MAPK3 TNF 15157285 277603 Positive_regulation MAPK3 TNF 15642133 102170 Positive_regulation MAPK3 TNF 15642133 102185 Positive_regulation MAPK3 TNF 15781582 1535129 Positive_regulation MAPK3 TNF 15841081 425538 Positive_regulation MAPK3 TNF 15841081 425539 Positive_regulation MAPK3 TNF 15841081 425873 Positive_regulation MAPK3 TNF 16100442 1634559 Positive_regulation MAPK3 TNF 16100442 1634633 Positive_regulation MAPK3 TNF 16207331 104244 Positive_regulation MAPK3 TNF 16207331 104283 Positive_regulation MAPK3 TNF 16207331 104284 Positive_regulation MAPK3 TNF 16207331 104329 Positive_regulation MAPK3 TNF 16207331 104330 Positive_regulation MAPK3 TNF 16207331 104356 Positive_regulation MAPK3 TNF 16207342 104520 Positive_regulation MAPK3 TNF 16207342 104572 Positive_regulation MAPK3 TNF 17283208 1544260 Positive_regulation MAPK3 TNF 17342245 810732 Positive_regulation MAPK3 TNF 18096615 2032352 Positive_regulation MAPK3 TNF 18404427 3087187 Positive_regulation MAPK3 TNF 18410682 110443 Positive_regulation MAPK3 TNF 19343193 1746547 Positive_regulation MAPK3 TNF 19442267 1696244 Positive_regulation MAPK3 TNF 19442267 1696272 Positive_regulation MAPK3 TNF 19707336 175503 Positive_regulation MAPK3 TNF 19723340 1227350 Positive_regulation MAPK3 TNF 19723340 1227357 Positive_regulation MAPK3 TNF 19723340 1227365 Positive_regulation MAPK3 TNF 19723340 1227379 Positive_regulation MAPK3 TNF 19723340 1227380 Positive_regulation MAPK3 TNF 19808894 711268 Positive_regulation MAPK3 TNF 19808894 711269 Positive_regulation MAPK3 TNF 19808894 711270 Positive_regulation MAPK3 TNF 19808894 711402 Positive_regulation MAPK3 TNF 19808894 711406 Positive_regulation MAPK3 TNF 19808894 711419 Positive_regulation MAPK3 TNF 20157567 26224 Positive_regulation MAPK3 TNF 20157567 26450 Positive_regulation MAPK3 TNF 20224659 1214054 Positive_regulation MAPK3 TNF 20308428 1373863 Positive_regulation MAPK3 TNF 20418897 9890 Positive_regulation MAPK3 TNF 20529221 34779 Positive_regulation MAPK3 TNF 20615213 119642 Positive_regulation MAPK3 TNF 20644550 10424 Positive_regulation MAPK3 TNF 20844314 27777 Positive_regulation MAPK3 TNF 20844314 28240 Positive_regulation MAPK3 TNF 20871620 11950 Positive_regulation MAPK3 TNF 20871620 11956 Positive_regulation MAPK3 TNF 20871620 11957 Positive_regulation MAPK3 TNF 20871620 11960 Positive_regulation MAPK3 TNF 21386087 718538 Positive_regulation MAPK3 TNF 21423395 955235 Positive_regulation MAPK3 TNF 21485745 734914 Positive_regulation MAPK3 TNF 21572963 2520301 Positive_regulation MAPK3 TNF 21837268 1082185 Positive_regulation MAPK3 TNF 21867555 1659580 Positive_regulation MAPK3 TNF 21867555 1659581 Positive_regulation MAPK3 TNF 21871121 1659631 Positive_regulation MAPK3 TNF 22082477 682557 Positive_regulation MAPK3 TNF 22194685 3055232 Positive_regulation MAPK3 TNF 22396737 2608354 Positive_regulation MAPK3 TNF 22396737 2608462 Positive_regulation MAPK3 TNF 22720116 2224476 Positive_regulation MAPK3 TNF 22802702 1714259 Positive_regulation MAPK3 TNF 22802702 1714272 Positive_regulation MAPK3 TNF 22802702 1714305 Positive_regulation MAPK3 TNF 22919361 3153837 Positive_regulation MAPK3 TNF 22988345 1750562 Positive_regulation MAPK3 TNF 23028407 2219777 Positive_regulation MAPK3 TNF 23071583 2703150 Positive_regulation MAPK3 TNF 23071583 2703171 Positive_regulation MAPK3 TNF 23152905 2716809 Positive_regulation MAPK3 TNF 23190711 1665179 Positive_regulation MAPK3 TNF 23282009 1665856 Positive_regulation MAPK3 TNF 23326019 1751335 Positive_regulation MAPK3 TNF 23331383 1675511 Positive_regulation MAPK3 TNF 23533994 180660 Positive_regulation MAPK3 TNF 23626383 1046757 Positive_regulation MAPK3 TNF 23663325 1154921 Positive_regulation MAPK3 TNF 23671702 2792495 Positive_regulation MAPK3 TNF 23671702 2792509 Positive_regulation MAPK3 TNF 23688423 314394 Positive_regulation MAPK3 TNF 23690670 1752162 Positive_regulation MAPK3 TNF 23755184 2801840 Positive_regulation MAPK3 TNF 23784308 606117 Positive_regulation MAPK3 TNF 23784308 606138 Positive_regulation MAPK3 TNF 23967215 2835002 Positive_regulation MAPK3 TNF 23977119 2838452 Positive_regulation MAPK3 TNF 24008729 565164 Positive_regulation MAPK3 TNF 24008729 565512 Positive_regulation MAPK3 TNF 24013271 2842023 Positive_regulation MAPK3 TNF 24024042 2003213 Positive_regulation MAPK3 TNF 24039713 2844611 Positive_regulation MAPK3 TNF 24039713 2844647 Positive_regulation MAPK3 TNF 24069158 2851398 Positive_regulation MAPK3 TNF 24069158 2851550 Positive_regulation MAPK3 TNF 24069158 2851551 Positive_regulation MAPK3 TNF 24086560 2854629 Positive_regulation MAPK3 TNF 24086560 2854640 Positive_regulation MAPK3 TNF 24086560 2854642 Positive_regulation MAPK3 TNF 24098442 2856364 Positive_regulation MAPK3 TNF 24098442 2856367 Positive_regulation MAPK3 TNF 24098442 2856370 Positive_regulation MAPK3 TNF 24101950 2227324 Positive_regulation MAPK3 TNF 24215724 538207 Positive_regulation MAPK3 TNF 24244348 2879498 Positive_regulation MAPK3 TNF 24266983 240391 Positive_regulation MAPK3 TNF 24285913 737682 Positive_regulation MAPK3 TNF 24307884 3155529 Positive_regulation MAPK3 TNF 24312381 2889127 Positive_regulation MAPK3 TNF 24377382 3225648 Positive_regulation MAPK3 TNF 24423080 538876 Positive_regulation MAPK3 TNF 24460683 240491 Positive_regulation MAPK3 TNF 24487321 1959841 Positive_regulation MAPK3 TNF 24489443 1757408 Positive_regulation MAPK3 TNF 24502696 1233044 Positive_regulation MAPK3 TNF 24502696 1233067 Positive_regulation MAPK3 TNF 24502696 1233120 Positive_regulation MAPK3 TNF 24502696 1233121 Positive_regulation MAPK3 TNF 24502696 1233165 Positive_regulation MAPK3 TNF 24502696 1233166 Positive_regulation MAPK3 TNF 24502696 1233167 Positive_regulation MAPK3 TNF 24502696 1233189 Positive_regulation MAPK3 TNF 24502696 1233223 Positive_regulation MAPK3 TNF 24502696 1233270 Positive_regulation MAPK3 TNF 24502696 1233297 Positive_regulation MAPK3 TNF 24587316 2929415 Positive_regulation MAPK3 TNF 24614867 2933186 Positive_regulation MAPK3 TNF 24616552 1757561 Positive_regulation MAPK3 TNF 24707477 188338 Positive_regulation MAPK3 TNF 24707477 188438 Positive_regulation MAPK3 TNF 24707477 188468 Positive_regulation MAPK3 TNF 24743742 573800 Positive_regulation MAPK3 TNF 24743742 573801 Positive_regulation MAPK3 TNF 24743742 573881 Positive_regulation MAPK3 TNF 24743742 573943 Positive_regulation MAPK3 TNF 24743742 574032 Positive_regulation MAPK3 TNF 24758719 1483152 Positive_regulation MAPK3 TNF 24773466 34208 Positive_regulation MAPK3 TNF 24821138 2969100 Positive_regulation MAPK3 TNF 24821138 2969101 Positive_regulation MAPK3 TNF 24868497 3179298 Positive_regulation MAPK3 TNF 24886088 347471 Positive_regulation MAPK3 TNF 25002903 826397 Positive_regulation MAPK3 TNF 25090227 2995086 Positive_regulation MAPK3 TNF 25110549 2229791 Positive_regulation MAPK3 TNF 25114952 3156817 Positive_regulation MAPK3 TNF 25114952 3156833 Positive_regulation MAPK3 TNF 25152756 826699 Positive_regulation MAPK3 TNF 25196285 3224115 Positive_regulation MAPK3 TNF 25200553 1234678 Positive_regulation MAPK3 TNF 25200553 1234692 Positive_regulation MAPK3 TNF 25206704 2005728 Positive_regulation MAPK3 TNF 25435878 1074935 Positive_regulation MAPK3 TNF 7525608 1436380 Positive_regulation MAPK3 TNF 7530764 1590001 Positive_regulation MAPK3 TNF 8562342 445250 Positive_regulation MAPK3 TNF 8666946 1597671 Positive_regulation MAPK3 TNFSF10 20204172 1747116 Positive_regulation MAPK3 TNFSF10 20204172 1747119 Positive_regulation MAPK3 TNFSF10 20204172 1747124 Positive_regulation MAPK3 TNFSF10 22462553 1230463 Positive_regulation MAPK3 TNFSF10 22719861 2653324 Positive_regulation MAPK3 TNFSF10 PMC2834064 134552 Positive_regulation MAPK4 ALOX5 22363611 2601206 Positive_regulation MAPK4 ALOX5 25025775 2989416 Positive_regulation MAPK4 ANGPT1 24013716 2842154 Positive_regulation MAPK4 ANGPT1 25329960 3017108 Positive_regulation MAPK4 ARSA 20339548 2444465 Positive_regulation MAPK4 ARSA 20339548 2444493 Positive_regulation MAPK4 CAPN8 24416390 2908405 Positive_regulation MAPK4 CCND1 22220184 1155998 Positive_regulation MAPK4 CCND1 25047753 240937 Positive_regulation MAPK4 CD14 20011115 3045935 Positive_regulation MAPK4 CD14 21387014 2506188 Positive_regulation MAPK4 CD14 24376813 2902232 Positive_regulation MAPK4 CHI3L1 23755018 961383 Positive_regulation MAPK4 CHI3L1 23972995 609001 Positive_regulation MAPK4 CHI3L1 23972995 609002 Positive_regulation MAPK4 CHI3L1 24729664 1758073 Positive_regulation MAPK4 CTGF 22135505 3128250 Positive_regulation MAPK4 CTGF 22918238 541776 Positive_regulation MAPK4 CTGF 23383241 2749649 Positive_regulation MAPK4 CTGF 23946690 1716069 Positive_regulation MAPK4 CYP24A1 22577546 1139593 Positive_regulation MAPK4 EDN2 12369712 1077818 Positive_regulation MAPK4 EDN2 24695532 2948242 Positive_regulation MAPK4 EPHB2 11783444 2001214 Positive_regulation MAPK4 EPHB2 18578886 356871 Positive_regulation MAPK4 EPHB2 19047466 1361978 Positive_regulation MAPK4 EPHB2 19047466 1361979 Positive_regulation MAPK4 EPHB2 19047466 1361980 Positive_regulation MAPK4 EPHB2 19047466 1362107 Positive_regulation MAPK4 EPHB2 19047466 1362108 Positive_regulation MAPK4 EPHB2 19047466 1362139 Positive_regulation MAPK4 EPHB2 19107595 1027494 Positive_regulation MAPK4 EPHB2 19357636 1902964 Positive_regulation MAPK4 EPHB2 20100173 212592 Positive_regulation MAPK4 EPHB2 21488184 3232794 Positive_regulation MAPK4 EPHB2 21488184 3232795 Positive_regulation MAPK4 EPHB2 21876711 813188 Positive_regulation MAPK4 EPHB2 22294469 135338 Positive_regulation MAPK4 EPHB2 22507553 1661735 Positive_regulation MAPK4 EPHB2 22675451 2648346 Positive_regulation MAPK4 EPHB2 22719861 2653327 Positive_regulation MAPK4 EPHB2 22723883 2655015 Positive_regulation MAPK4 EPHB2 22741533 381931 Positive_regulation MAPK4 EPHB2 22951718 1631194 Positive_regulation MAPK4 EPHB2 23383241 2749650 Positive_regulation MAPK4 EPHB2 23388501 1920512 Positive_regulation MAPK4 EPHB2 23738323 181931 Positive_regulation MAPK4 EPHB2 23826208 2811467 Positive_regulation MAPK4 EPHB2 24098984 1726346 Positive_regulation MAPK4 EPHB2 24823621 1624669 Positive_regulation MAPK4 EPHB2 24885161 396508 Positive_regulation MAPK4 EPHB2 24978597 2985609 Positive_regulation MAPK4 EPHB2 25299961 174476 Positive_regulation MAPK4 F2R 21378407 2175460 Positive_regulation MAPK4 F2R 21760880 2535521 Positive_regulation MAPK4 F2R 21760880 2535783 Positive_regulation MAPK4 F2R 21845431 3158101 Positive_regulation MAPK4 F2R 24215724 538277 Positive_regulation MAPK4 F2R 24278684 3150070 Positive_regulation MAPK4 F2R 24743392 2955222 Positive_regulation MAPK4 F2R 24743392 2955354 Positive_regulation MAPK4 F2R 24743392 2955415 Positive_regulation MAPK4 F2R 24860547 880688 Positive_regulation MAPK4 FAS 11259103 418457 Positive_regulation MAPK4 FAS 14970175 1531125 Positive_regulation MAPK4 FAS 19487421 1555066 Positive_regulation MAPK4 FAS 19564926 1055591 Positive_regulation MAPK4 FAS 20573240 1856431 Positive_regulation MAPK4 FAS 20573240 1856457 Positive_regulation MAPK4 FAS 21477291 527146 Positive_regulation MAPK4 FAS 21975294 552712 Positive_regulation MAPK4 FAS 21975294 552713 Positive_regulation MAPK4 FAS 21975294 552714 Positive_regulation MAPK4 FAS 21975294 552715 Positive_regulation MAPK4 FAS 21975294 552716 Positive_regulation MAPK4 FAS 21975294 552717 Positive_regulation MAPK4 FAS 21975294 552807 Positive_regulation MAPK4 FAS 21975294 552808 Positive_regulation MAPK4 FAS 21975294 552809 Positive_regulation MAPK4 FAS 21975294 552922 Positive_regulation MAPK4 FAS 21975294 552923 Positive_regulation MAPK4 FAS 21975294 552924 Positive_regulation MAPK4 FAS 21975294 553107 Positive_regulation MAPK4 FAS 23029562 2698773 Positive_regulation MAPK4 FAS 23029562 2698794 Positive_regulation MAPK4 FAS 23852022 1108463 Positive_regulation MAPK4 FAS 25196936 1730935 Positive_regulation MAPK4 FAS 9362518 1464817 Positive_regulation MAPK4 FBXO32 22082477 682649 Positive_regulation MAPK4 FBXO32 23046544 3161240 Positive_regulation MAPK4 FOXO1 20375467 26977 Positive_regulation MAPK4 GLP1R 23536825 2773064 Positive_regulation MAPK4 GPR115 22570668 635611 Positive_regulation MAPK4 GPR132 22570668 635600 Positive_regulation MAPK4 GPR87 22570668 635680 Positive_regulation MAPK4 HBEGF 15817123 1844615 Positive_regulation MAPK4 HBEGF 15817123 1844695 Positive_regulation MAPK4 HBEGF 22259731 1146104 Positive_regulation MAPK4 HBEGF 22792252 2661662 Positive_regulation MAPK4 HBEGF PMC3760629 1606205 Positive_regulation MAPK4 IFI27 11560992 1520886 Positive_regulation MAPK4 ITGB2 21206905 2491116 Positive_regulation MAPK4 ITGB2 23508943 906520 Positive_regulation MAPK4 MAP2K6 10330402 1246242 Positive_regulation MAPK4 MAP2K6 10737387 417005 Positive_regulation MAPK4 MAP2K6 11259103 418459 Positive_regulation MAPK4 MAP2K6 12117640 791095 Positive_regulation MAPK4 MAP2K6 14981092 1306481 Positive_regulation MAPK4 MAP2K6 16048647 3105345 Positive_regulation MAPK4 MAP2K6 17525795 2014000 Positive_regulation MAPK4 MAP2K6 17576777 1546470 Positive_regulation MAPK4 MAP2K6 18955270 811007 Positive_regulation MAPK4 MAP2K6 19159010 1055161 Positive_regulation MAPK4 MAP2K6 19159010 1055379 Positive_regulation MAPK4 MAP2K6 19426550 282560 Positive_regulation MAPK4 MAP2K6 20221403 2442597 Positive_regulation MAPK4 MAP2K6 20463961 2449791 Positive_regulation MAPK4 MAP2K6 20802223 2253142 Positive_regulation MAPK4 MAP2K6 20955562 120563 Positive_regulation MAPK4 MAP2K6 20955562 120659 Positive_regulation MAPK4 MAP2K6 21345249 121666 Positive_regulation MAPK4 MAP2K6 22028883 2564943 Positive_regulation MAPK4 MAP2K6 22159586 600590 Positive_regulation MAPK4 MAP2K6 22245064 613592 Positive_regulation MAPK4 MAP2K6 22359624 2598546 Positive_regulation MAPK4 MAP2K6 22415879 722027 Positive_regulation MAPK4 MAP2K6 22415879 722357 Positive_regulation MAPK4 MAP2K6 22529896 2620593 Positive_regulation MAPK4 MAP2K6 22740774 490726 Positive_regulation MAPK4 MAP2K6 22870983 288771 Positive_regulation MAPK4 MAP2K6 22870983 288910 Positive_regulation MAPK4 MAP2K6 22870983 289019 Positive_regulation MAPK4 MAP2K6 23115639 2711461 Positive_regulation MAPK4 MAP2K6 23166686 2718511 Positive_regulation MAPK4 MAP2K6 23535559 1721184 Positive_regulation MAPK4 MAP2K6 23772401 852593 Positive_regulation MAPK4 MAP2K6 23936348 2830143 Positive_regulation MAPK4 MAP2K6 24566153 1124361 Positive_regulation MAPK4 MAP2K6 24792484 2960487 Positive_regulation MAPK4 MAP2K6 25364728 861783 Positive_regulation MAPK4 MAP2K6 25479605 3032559 Positive_regulation MAPK4 MAP2K6 9700154 1469476 Positive_regulation MAPK4 MIP 19781090 1625742 Positive_regulation MAPK4 MIP 21977329 1082351 Positive_regulation MAPK4 MMP28 18778487 384793 Positive_regulation MAPK4 MMP28 23688423 313964 Positive_regulation MAPK4 MMP28 23688423 314423 Positive_regulation MAPK4 MMP28 23878609 821889 Positive_regulation MAPK4 MMP28 25520932 203142 Positive_regulation MAPK4 MMP7 23688423 313979 Positive_regulation MAPK4 MMP7 23688423 314439 Positive_regulation MAPK4 MMP7 23878609 821905 Positive_regulation MAPK4 MMP7 25520932 203157 Positive_regulation MAPK4 MUC16 17029558 2303097 Positive_regulation MAPK4 MUC16 23694968 3135925 Positive_regulation MAPK4 NGFR 22880054 2673873 Positive_regulation MAPK4 NR2F1 24906407 273652 Positive_regulation MAPK4 OXTR 22190926 1072840 Positive_regulation MAPK4 PLAU 23724131 2799129 Positive_regulation MAPK4 PLAU 23724131 2799389 Positive_regulation MAPK4 PTGER2 25327961 216578 Positive_regulation MAPK4 RCAN1 19124655 1553356 Positive_regulation MAPK4 RCAN1 19124655 1553476 Positive_regulation MAPK4 RGS2 24743392 2955355 Positive_regulation MAPK4 S100B 22276098 2589829 Positive_regulation MAPK4 S100B 23259641 1665768 Positive_regulation MAPK4 S100B 23259641 1665782 Positive_regulation MAPK4 S100B 23259641 1665796 Positive_regulation MAPK4 SCGB3A1 22289642 335849 Positive_regulation MAPK4 SLC6A2 18509476 2389902 Positive_regulation MAPK4 SPHK1 16847102 1331308 Positive_regulation MAPK4 SPHK1 20498849 2451137 Positive_regulation MAPK4 SPHK1 20498849 2451172 Positive_regulation MAPK4 TLR7 19043549 3042413 Positive_regulation MAPK4 TLR7 19043549 3042557 Positive_regulation MAPK4 TLR7 19371402 733981 Positive_regulation MAPK4 TLR7 19685283 495422 Positive_regulation MAPK4 TLR7 20832340 1040238 Positive_regulation MAPK4 TLR7 21633096 1992447 Positive_regulation MAPK4 TLR7 21743791 1028475 Positive_regulation MAPK4 TLR7 21943110 2231377 Positive_regulation MAPK4 TLR7 22110382 1058353 Positive_regulation MAPK4 TLR7 22216226 2584858 Positive_regulation MAPK4 TLR7 22829768 3058419 Positive_regulation MAPK4 TLR7 23202320 3184708 Positive_regulation MAPK4 TLR7 23305364 694010 Positive_regulation MAPK4 TLR7 23521892 3215348 Positive_regulation MAPK4 TLR7 23603814 1962893 Positive_regulation MAPK4 TLR7 23760366 2211942 Positive_regulation MAPK4 TLR7 23840534 2815017 Positive_regulation MAPK4 TLR7 24489933 2916851 Positive_regulation MAPK4 TLR7 24603716 2932091 Positive_regulation MAPK4 TLR7 24772440 189746 Positive_regulation MAPK4 TLR7 24800851 2961064 Positive_regulation MAPK4 TLR7 25177436 647006 Positive_regulation MAPK4 TNF 11015442 1517394 Positive_regulation MAPK4 TNF 11015442 1517425 Positive_regulation MAPK4 TNF 11015442 1517438 Positive_regulation MAPK4 TNF 11015442 1517451 Positive_regulation MAPK4 TNF 14613529 3095428 Positive_regulation MAPK4 TNF 15157285 277604 Positive_regulation MAPK4 TNF 15642133 102187 Positive_regulation MAPK4 TNF 15781582 1535130 Positive_regulation MAPK4 TNF 15841081 425540 Positive_regulation MAPK4 TNF 15841081 425541 Positive_regulation MAPK4 TNF 15841081 425874 Positive_regulation MAPK4 TNF 16100442 1634571 Positive_regulation MAPK4 TNF 16100442 1634634 Positive_regulation MAPK4 TNF 16207331 104245 Positive_regulation MAPK4 TNF 16207331 104285 Positive_regulation MAPK4 TNF 16207331 104286 Positive_regulation MAPK4 TNF 16207331 104332 Positive_regulation MAPK4 TNF 16207331 104333 Positive_regulation MAPK4 TNF 16207331 104357 Positive_regulation MAPK4 TNF 16207342 104521 Positive_regulation MAPK4 TNF 16207342 104573 Positive_regulation MAPK4 TNF 17283208 1544261 Positive_regulation MAPK4 TNF 17342245 810733 Positive_regulation MAPK4 TNF 18096615 2032354 Positive_regulation MAPK4 TNF 18404427 3087188 Positive_regulation MAPK4 TNF 18410682 110444 Positive_regulation MAPK4 TNF 19343193 1746548 Positive_regulation MAPK4 TNF 19442267 1696273 Positive_regulation MAPK4 TNF 19707336 175505 Positive_regulation MAPK4 TNF 19723340 1227351 Positive_regulation MAPK4 TNF 19723340 1227366 Positive_regulation MAPK4 TNF 19723340 1227381 Positive_regulation MAPK4 TNF 20157567 26227 Positive_regulation MAPK4 TNF 20157567 26451 Positive_regulation MAPK4 TNF 20308428 1373864 Positive_regulation MAPK4 TNF 20418897 9891 Positive_regulation MAPK4 TNF 20529221 34780 Positive_regulation MAPK4 TNF 20615213 119645 Positive_regulation MAPK4 TNF 20644550 10425 Positive_regulation MAPK4 TNF 20844314 27778 Positive_regulation MAPK4 TNF 20844314 28241 Positive_regulation MAPK4 TNF 20871620 11951 Positive_regulation MAPK4 TNF 21386087 718540 Positive_regulation MAPK4 TNF 21423395 955237 Positive_regulation MAPK4 TNF 21485745 734916 Positive_regulation MAPK4 TNF 21572963 2520302 Positive_regulation MAPK4 TNF 21837268 1082186 Positive_regulation MAPK4 TNF 21867555 1659582 Positive_regulation MAPK4 TNF 21871121 1659632 Positive_regulation MAPK4 TNF 22082477 682559 Positive_regulation MAPK4 TNF 22194685 3055233 Positive_regulation MAPK4 TNF 22802702 1714260 Positive_regulation MAPK4 TNF 22802702 1714273 Positive_regulation MAPK4 TNF 22802702 1714306 Positive_regulation MAPK4 TNF 22988345 1750563 Positive_regulation MAPK4 TNF 23028407 2219781 Positive_regulation MAPK4 TNF 23071583 2703151 Positive_regulation MAPK4 TNF 23071583 2703172 Positive_regulation MAPK4 TNF 23152905 2716810 Positive_regulation MAPK4 TNF 23190711 1665180 Positive_regulation MAPK4 TNF 23282009 1665857 Positive_regulation MAPK4 TNF 23326019 1751336 Positive_regulation MAPK4 TNF 23331383 1675513 Positive_regulation MAPK4 TNF 23533994 180661 Positive_regulation MAPK4 TNF 23626383 1046759 Positive_regulation MAPK4 TNF 23671702 2792496 Positive_regulation MAPK4 TNF 23688423 314418 Positive_regulation MAPK4 TNF 23690670 1752164 Positive_regulation MAPK4 TNF 23755184 2801841 Positive_regulation MAPK4 TNF 23784308 606118 Positive_regulation MAPK4 TNF 23784308 606140 Positive_regulation MAPK4 TNF 23967215 2835005 Positive_regulation MAPK4 TNF 23977119 2838453 Positive_regulation MAPK4 TNF 24008729 565165 Positive_regulation MAPK4 TNF 24008729 565513 Positive_regulation MAPK4 TNF 24024042 2003214 Positive_regulation MAPK4 TNF 24069158 2851403 Positive_regulation MAPK4 TNF 24069158 2851552 Positive_regulation MAPK4 TNF 24069158 2851553 Positive_regulation MAPK4 TNF 24086560 2854630 Positive_regulation MAPK4 TNF 24101950 2227325 Positive_regulation MAPK4 TNF 24244348 2879499 Positive_regulation MAPK4 TNF 24266983 240392 Positive_regulation MAPK4 TNF 24285913 737683 Positive_regulation MAPK4 TNF 24307884 3155530 Positive_regulation MAPK4 TNF 24377382 3225649 Positive_regulation MAPK4 TNF 24423080 538877 Positive_regulation MAPK4 TNF 24460683 240492 Positive_regulation MAPK4 TNF 24487321 1959842 Positive_regulation MAPK4 TNF 24489443 1757409 Positive_regulation MAPK4 TNF 24502696 1233045 Positive_regulation MAPK4 TNF 24502696 1233068 Positive_regulation MAPK4 TNF 24502696 1233122 Positive_regulation MAPK4 TNF 24502696 1233123 Positive_regulation MAPK4 TNF 24502696 1233168 Positive_regulation MAPK4 TNF 24502696 1233169 Positive_regulation MAPK4 TNF 24502696 1233224 Positive_regulation MAPK4 TNF 24502696 1233272 Positive_regulation MAPK4 TNF 24502696 1233298 Positive_regulation MAPK4 TNF 24587316 2929416 Positive_regulation MAPK4 TNF 24614867 2933187 Positive_regulation MAPK4 TNF 24616552 1757562 Positive_regulation MAPK4 TNF 24707477 188343 Positive_regulation MAPK4 TNF 24707477 188439 Positive_regulation MAPK4 TNF 24707477 188469 Positive_regulation MAPK4 TNF 24758719 1483153 Positive_regulation MAPK4 TNF 24773466 34209 Positive_regulation MAPK4 TNF 24821138 2969102 Positive_regulation MAPK4 TNF 24886088 347472 Positive_regulation MAPK4 TNF 25090227 2995087 Positive_regulation MAPK4 TNF 25110549 2229792 Positive_regulation MAPK4 TNF 25114952 3156818 Positive_regulation MAPK4 TNF 25114952 3156834 Positive_regulation MAPK4 TNF 25152756 826701 Positive_regulation MAPK4 TNF 25196285 3224116 Positive_regulation MAPK4 TNF 25206704 2005729 Positive_regulation MAPK4 TNF 25435878 1074936 Positive_regulation MAPK4 TNF 7525608 1436381 Positive_regulation MAPK4 TNF 7530764 1590002 Positive_regulation MAPK4 TNF 8562342 445251 Positive_regulation MAPK4 TNF 8666946 1597672 Positive_regulation MAPK4 TNFSF10 22462553 1230464 Positive_regulation MAPK4 TNFSF10 22719861 2653326 Positive_regulation MAPK6 ALOX5 22363611 2601207 Positive_regulation MAPK6 ALOX5 25025775 2989417 Positive_regulation MAPK6 ANGPT1 24013716 2842155 Positive_regulation MAPK6 ANGPT1 25329960 3017111 Positive_regulation MAPK6 ARSA 20339548 2444466 Positive_regulation MAPK6 ARSA 20339548 2444494 Positive_regulation MAPK6 CAPN8 24416390 2908419 Positive_regulation MAPK6 CCND1 22220184 1155999 Positive_regulation MAPK6 CCND1 25047753 240945 Positive_regulation MAPK6 CD14 20011115 3045936 Positive_regulation MAPK6 CD14 21387014 2506189 Positive_regulation MAPK6 CD14 24376813 2902235 Positive_regulation MAPK6 CHI3L1 23755018 961386 Positive_regulation MAPK6 CHI3L1 23972995 609003 Positive_regulation MAPK6 CHI3L1 23972995 609004 Positive_regulation MAPK6 CHI3L1 24729664 1758074 Positive_regulation MAPK6 CTGF 22135505 3128251 Positive_regulation MAPK6 CTGF 22918238 541777 Positive_regulation MAPK6 CTGF 23383241 2749651 Positive_regulation MAPK6 CTGF 23946690 1716070 Positive_regulation MAPK6 CYP24A1 22577546 1139594 Positive_regulation MAPK6 EDN2 12369712 1077821 Positive_regulation MAPK6 EDN2 24695532 2948245 Positive_regulation MAPK6 EPHB2 11783444 2001215 Positive_regulation MAPK6 EPHB2 18578886 356872 Positive_regulation MAPK6 EPHB2 19047466 1361981 Positive_regulation MAPK6 EPHB2 19047466 1361982 Positive_regulation MAPK6 EPHB2 19047466 1361983 Positive_regulation MAPK6 EPHB2 19047466 1362109 Positive_regulation MAPK6 EPHB2 19047466 1362110 Positive_regulation MAPK6 EPHB2 19047466 1362140 Positive_regulation MAPK6 EPHB2 19107595 1027496 Positive_regulation MAPK6 EPHB2 19357636 1902966 Positive_regulation MAPK6 EPHB2 20100173 212593 Positive_regulation MAPK6 EPHB2 21488184 3232796 Positive_regulation MAPK6 EPHB2 21488184 3232797 Positive_regulation MAPK6 EPHB2 21876711 813189 Positive_regulation MAPK6 EPHB2 22294469 135339 Positive_regulation MAPK6 EPHB2 22507553 1661741 Positive_regulation MAPK6 EPHB2 22675451 2648349 Positive_regulation MAPK6 EPHB2 22719861 2653329 Positive_regulation MAPK6 EPHB2 22723883 2655016 Positive_regulation MAPK6 EPHB2 22741533 381933 Positive_regulation MAPK6 EPHB2 22951718 1631195 Positive_regulation MAPK6 EPHB2 23383241 2749652 Positive_regulation MAPK6 EPHB2 23388501 1920513 Positive_regulation MAPK6 EPHB2 23738323 181933 Positive_regulation MAPK6 EPHB2 23826208 2811468 Positive_regulation MAPK6 EPHB2 24098984 1726347 Positive_regulation MAPK6 EPHB2 24823621 1624670 Positive_regulation MAPK6 EPHB2 24885161 396509 Positive_regulation MAPK6 EPHB2 24978597 2985610 Positive_regulation MAPK6 EPHB2 25299961 174477 Positive_regulation MAPK6 F2R 21378407 2175461 Positive_regulation MAPK6 F2R 21760880 2535527 Positive_regulation MAPK6 F2R 21760880 2535789 Positive_regulation MAPK6 F2R 21845431 3158102 Positive_regulation MAPK6 F2R 24215724 538278 Positive_regulation MAPK6 F2R 24278684 3150071 Positive_regulation MAPK6 F2R 24743392 2955225 Positive_regulation MAPK6 F2R 24743392 2955357 Positive_regulation MAPK6 F2R 24743392 2955416 Positive_regulation MAPK6 F2R 24860547 880691 Positive_regulation MAPK6 FAS 11259103 418460 Positive_regulation MAPK6 FAS 14970175 1531126 Positive_regulation MAPK6 FAS 19487421 1555068 Positive_regulation MAPK6 FAS 19564926 1055592 Positive_regulation MAPK6 FAS 20573240 1856432 Positive_regulation MAPK6 FAS 20573240 1856458 Positive_regulation MAPK6 FAS 21477291 527147 Positive_regulation MAPK6 FAS 21975294 552718 Positive_regulation MAPK6 FAS 21975294 552719 Positive_regulation MAPK6 FAS 21975294 552720 Positive_regulation MAPK6 FAS 21975294 552721 Positive_regulation MAPK6 FAS 21975294 552722 Positive_regulation MAPK6 FAS 21975294 552723 Positive_regulation MAPK6 FAS 21975294 552810 Positive_regulation MAPK6 FAS 21975294 552811 Positive_regulation MAPK6 FAS 21975294 552812 Positive_regulation MAPK6 FAS 21975294 552928 Positive_regulation MAPK6 FAS 21975294 552929 Positive_regulation MAPK6 FAS 21975294 552930 Positive_regulation MAPK6 FAS 21975294 553121 Positive_regulation MAPK6 FAS 23029562 2698774 Positive_regulation MAPK6 FAS 23029562 2698795 Positive_regulation MAPK6 FAS 23852022 1108464 Positive_regulation MAPK6 FAS 25196936 1730937 Positive_regulation MAPK6 FAS 9362518 1464819 Positive_regulation MAPK6 FBXO32 22082477 682652 Positive_regulation MAPK6 FBXO32 23046544 3161241 Positive_regulation MAPK6 FOXO1 20375467 26981 Positive_regulation MAPK6 GLP1R 23536825 2773065 Positive_regulation MAPK6 GPR115 22570668 635704 Positive_regulation MAPK6 GPR132 22570668 635693 Positive_regulation MAPK6 GPR87 22570668 635773 Positive_regulation MAPK6 HBEGF 15817123 1844618 Positive_regulation MAPK6 HBEGF 15817123 1844697 Positive_regulation MAPK6 HBEGF 22259731 1146105 Positive_regulation MAPK6 HBEGF 22792252 2661663 Positive_regulation MAPK6 HBEGF PMC3760629 1606206 Positive_regulation MAPK6 IFI27 11560992 1520888 Positive_regulation MAPK6 ITGB2 21206905 2491118 Positive_regulation MAPK6 ITGB2 23508943 906522 Positive_regulation MAPK6 MAP2K6 10330402 1246244 Positive_regulation MAPK6 MAP2K6 10737387 417012 Positive_regulation MAPK6 MAP2K6 11259103 418462 Positive_regulation MAPK6 MAP2K6 12117640 791102 Positive_regulation MAPK6 MAP2K6 14981092 1306489 Positive_regulation MAPK6 MAP2K6 16048647 3105352 Positive_regulation MAPK6 MAP2K6 17525795 2014001 Positive_regulation MAPK6 MAP2K6 17576777 1546477 Positive_regulation MAPK6 MAP2K6 18955270 811020 Positive_regulation MAPK6 MAP2K6 19159010 1055162 Positive_regulation MAPK6 MAP2K6 19159010 1055380 Positive_regulation MAPK6 MAP2K6 19426550 282567 Positive_regulation MAPK6 MAP2K6 20221403 2442599 Positive_regulation MAPK6 MAP2K6 20463961 2449793 Positive_regulation MAPK6 MAP2K6 20802223 2253143 Positive_regulation MAPK6 MAP2K6 20955562 120567 Positive_regulation MAPK6 MAP2K6 20955562 120661 Positive_regulation MAPK6 MAP2K6 21345249 121673 Positive_regulation MAPK6 MAP2K6 22028883 2564950 Positive_regulation MAPK6 MAP2K6 22159586 600597 Positive_regulation MAPK6 MAP2K6 22245064 613599 Positive_regulation MAPK6 MAP2K6 22359624 2598554 Positive_regulation MAPK6 MAP2K6 22415879 722032 Positive_regulation MAPK6 MAP2K6 22415879 722362 Positive_regulation MAPK6 MAP2K6 22529896 2620600 Positive_regulation MAPK6 MAP2K6 22740774 490733 Positive_regulation MAPK6 MAP2K6 22870983 288772 Positive_regulation MAPK6 MAP2K6 22870983 288911 Positive_regulation MAPK6 MAP2K6 22870983 289020 Positive_regulation MAPK6 MAP2K6 23115639 2711463 Positive_regulation MAPK6 MAP2K6 23166686 2718518 Positive_regulation MAPK6 MAP2K6 23535559 1721193 Positive_regulation MAPK6 MAP2K6 23772401 852632 Positive_regulation MAPK6 MAP2K6 23936348 2830150 Positive_regulation MAPK6 MAP2K6 24566153 1124368 Positive_regulation MAPK6 MAP2K6 24792484 2960494 Positive_regulation MAPK6 MAP2K6 25364728 861785 Positive_regulation MAPK6 MAP2K6 25479605 3032566 Positive_regulation MAPK6 MAP2K6 9700154 1469483 Positive_regulation MAPK6 MIP 19781090 1625743 Positive_regulation MAPK6 MIP 21977329 1082352 Positive_regulation MAPK6 MMP28 18778487 384794 Positive_regulation MAPK6 MMP28 23688423 313986 Positive_regulation MAPK6 MMP28 23688423 314447 Positive_regulation MAPK6 MMP28 23878609 821912 Positive_regulation MAPK6 MMP28 25520932 203164 Positive_regulation MAPK6 MMP7 23688423 314001 Positive_regulation MAPK6 MMP7 23688423 314463 Positive_regulation MAPK6 MMP7 23878609 821928 Positive_regulation MAPK6 MMP7 25520932 203179 Positive_regulation MAPK6 MUC16 17029558 2303113 Positive_regulation MAPK6 MUC16 23694968 3135928 Positive_regulation MAPK6 NGFR 22880054 2673875 Positive_regulation MAPK6 NR2F1 24906407 273653 Positive_regulation MAPK6 OXTR 22190926 1072841 Positive_regulation MAPK6 PLAU 23724131 2799131 Positive_regulation MAPK6 PLAU 23724131 2799390 Positive_regulation MAPK6 PTGER2 25327961 216579 Positive_regulation MAPK6 RCAN1 19124655 1553357 Positive_regulation MAPK6 RCAN1 19124655 1553477 Positive_regulation MAPK6 RGS2 24743392 2955358 Positive_regulation MAPK6 S100B 22276098 2589831 Positive_regulation MAPK6 S100B 23259641 1665769 Positive_regulation MAPK6 S100B 23259641 1665783 Positive_regulation MAPK6 S100B 23259641 1665797 Positive_regulation MAPK6 SCGB3A1 22289642 335850 Positive_regulation MAPK6 SLC6A2 18509476 2389903 Positive_regulation MAPK6 SPHK1 16847102 1331310 Positive_regulation MAPK6 SPHK1 20498849 2451138 Positive_regulation MAPK6 SPHK1 20498849 2451173 Positive_regulation MAPK6 TLR7 19043549 3042423 Positive_regulation MAPK6 TLR7 19043549 3042567 Positive_regulation MAPK6 TLR7 19371402 733991 Positive_regulation MAPK6 TLR7 19685283 495432 Positive_regulation MAPK6 TLR7 20832340 1040239 Positive_regulation MAPK6 TLR7 21633096 1992457 Positive_regulation MAPK6 TLR7 21743791 1028485 Positive_regulation MAPK6 TLR7 21943110 2231387 Positive_regulation MAPK6 TLR7 22110382 1058363 Positive_regulation MAPK6 TLR7 22216226 2584868 Positive_regulation MAPK6 TLR7 22829768 3058429 Positive_regulation MAPK6 TLR7 23202320 3184719 Positive_regulation MAPK6 TLR7 23305364 694020 Positive_regulation MAPK6 TLR7 23521892 3215358 Positive_regulation MAPK6 TLR7 23603814 1962905 Positive_regulation MAPK6 TLR7 23760366 2211952 Positive_regulation MAPK6 TLR7 23840534 2815027 Positive_regulation MAPK6 TLR7 24489933 2916861 Positive_regulation MAPK6 TLR7 24603716 2932101 Positive_regulation MAPK6 TLR7 24772440 189756 Positive_regulation MAPK6 TLR7 24800851 2961074 Positive_regulation MAPK6 TLR7 25177436 647016 Positive_regulation MAPK6 TNF 11015442 1517396 Positive_regulation MAPK6 TNF 11015442 1517426 Positive_regulation MAPK6 TNF 11015442 1517439 Positive_regulation MAPK6 TNF 11015442 1517452 Positive_regulation MAPK6 TNF 14613529 3095429 Positive_regulation MAPK6 TNF 15157285 277605 Positive_regulation MAPK6 TNF 15642133 102189 Positive_regulation MAPK6 TNF 15781582 1535131 Positive_regulation MAPK6 TNF 15841081 425542 Positive_regulation MAPK6 TNF 15841081 425543 Positive_regulation MAPK6 TNF 15841081 425875 Positive_regulation MAPK6 TNF 16100442 1634583 Positive_regulation MAPK6 TNF 16100442 1634635 Positive_regulation MAPK6 TNF 16207331 104246 Positive_regulation MAPK6 TNF 16207331 104287 Positive_regulation MAPK6 TNF 16207331 104288 Positive_regulation MAPK6 TNF 16207331 104335 Positive_regulation MAPK6 TNF 16207331 104336 Positive_regulation MAPK6 TNF 16207331 104358 Positive_regulation MAPK6 TNF 16207342 104522 Positive_regulation MAPK6 TNF 16207342 104574 Positive_regulation MAPK6 TNF 17283208 1544262 Positive_regulation MAPK6 TNF 17342245 810734 Positive_regulation MAPK6 TNF 18096615 2032356 Positive_regulation MAPK6 TNF 18404427 3087189 Positive_regulation MAPK6 TNF 18410682 110445 Positive_regulation MAPK6 TNF 19343193 1746549 Positive_regulation MAPK6 TNF 19442267 1696274 Positive_regulation MAPK6 TNF 19707336 175507 Positive_regulation MAPK6 TNF 19723340 1227352 Positive_regulation MAPK6 TNF 19723340 1227367 Positive_regulation MAPK6 TNF 19723340 1227382 Positive_regulation MAPK6 TNF 20157567 26230 Positive_regulation MAPK6 TNF 20157567 26452 Positive_regulation MAPK6 TNF 20308428 1373865 Positive_regulation MAPK6 TNF 20418897 9892 Positive_regulation MAPK6 TNF 20529221 34781 Positive_regulation MAPK6 TNF 20615213 119648 Positive_regulation MAPK6 TNF 20644550 10426 Positive_regulation MAPK6 TNF 20844314 27779 Positive_regulation MAPK6 TNF 20844314 28242 Positive_regulation MAPK6 TNF 20871620 11952 Positive_regulation MAPK6 TNF 21386087 718542 Positive_regulation MAPK6 TNF 21423395 955239 Positive_regulation MAPK6 TNF 21485745 734918 Positive_regulation MAPK6 TNF 21572963 2520303 Positive_regulation MAPK6 TNF 21837268 1082187 Positive_regulation MAPK6 TNF 21867555 1659583 Positive_regulation MAPK6 TNF 21871121 1659633 Positive_regulation MAPK6 TNF 22082477 682561 Positive_regulation MAPK6 TNF 22194685 3055234 Positive_regulation MAPK6 TNF 22802702 1714261 Positive_regulation MAPK6 TNF 22802702 1714274 Positive_regulation MAPK6 TNF 22802702 1714307 Positive_regulation MAPK6 TNF 22988345 1750564 Positive_regulation MAPK6 TNF 23028407 2219785 Positive_regulation MAPK6 TNF 23071583 2703152 Positive_regulation MAPK6 TNF 23071583 2703173 Positive_regulation MAPK6 TNF 23152905 2716811 Positive_regulation MAPK6 TNF 23190711 1665181 Positive_regulation MAPK6 TNF 23282009 1665858 Positive_regulation MAPK6 TNF 23326019 1751337 Positive_regulation MAPK6 TNF 23331383 1675515 Positive_regulation MAPK6 TNF 23533994 180662 Positive_regulation MAPK6 TNF 23626383 1046761 Positive_regulation MAPK6 TNF 23671702 2792497 Positive_regulation MAPK6 TNF 23688423 314442 Positive_regulation MAPK6 TNF 23690670 1752166 Positive_regulation MAPK6 TNF 23755184 2801842 Positive_regulation MAPK6 TNF 23784308 606119 Positive_regulation MAPK6 TNF 23784308 606142 Positive_regulation MAPK6 TNF 23967215 2835008 Positive_regulation MAPK6 TNF 23977119 2838454 Positive_regulation MAPK6 TNF 24008729 565166 Positive_regulation MAPK6 TNF 24008729 565514 Positive_regulation MAPK6 TNF 24024042 2003215 Positive_regulation MAPK6 TNF 24069158 2851408 Positive_regulation MAPK6 TNF 24069158 2851554 Positive_regulation MAPK6 TNF 24069158 2851555 Positive_regulation MAPK6 TNF 24086560 2854631 Positive_regulation MAPK6 TNF 24101950 2227326 Positive_regulation MAPK6 TNF 24244348 2879500 Positive_regulation MAPK6 TNF 24266983 240393 Positive_regulation MAPK6 TNF 24285913 737684 Positive_regulation MAPK6 TNF 24307884 3155531 Positive_regulation MAPK6 TNF 24377382 3225650 Positive_regulation MAPK6 TNF 24423080 538878 Positive_regulation MAPK6 TNF 24460683 240493 Positive_regulation MAPK6 TNF 24487321 1959843 Positive_regulation MAPK6 TNF 24489443 1757410 Positive_regulation MAPK6 TNF 24502696 1233046 Positive_regulation MAPK6 TNF 24502696 1233069 Positive_regulation MAPK6 TNF 24502696 1233124 Positive_regulation MAPK6 TNF 24502696 1233125 Positive_regulation MAPK6 TNF 24502696 1233170 Positive_regulation MAPK6 TNF 24502696 1233171 Positive_regulation MAPK6 TNF 24502696 1233225 Positive_regulation MAPK6 TNF 24502696 1233274 Positive_regulation MAPK6 TNF 24502696 1233299 Positive_regulation MAPK6 TNF 24587316 2929417 Positive_regulation MAPK6 TNF 24614867 2933188 Positive_regulation MAPK6 TNF 24616552 1757563 Positive_regulation MAPK6 TNF 24707477 188348 Positive_regulation MAPK6 TNF 24707477 188440 Positive_regulation MAPK6 TNF 24707477 188470 Positive_regulation MAPK6 TNF 24758719 1483154 Positive_regulation MAPK6 TNF 24773466 34210 Positive_regulation MAPK6 TNF 24821138 2969103 Positive_regulation MAPK6 TNF 24886088 347473 Positive_regulation MAPK6 TNF 25090227 2995088 Positive_regulation MAPK6 TNF 25110549 2229793 Positive_regulation MAPK6 TNF 25114952 3156819 Positive_regulation MAPK6 TNF 25114952 3156835 Positive_regulation MAPK6 TNF 25152756 826703 Positive_regulation MAPK6 TNF 25196285 3224117 Positive_regulation MAPK6 TNF 25206704 2005730 Positive_regulation MAPK6 TNF 25435878 1074937 Positive_regulation MAPK6 TNF 7525608 1436382 Positive_regulation MAPK6 TNF 7530764 1590003 Positive_regulation MAPK6 TNF 8562342 445252 Positive_regulation MAPK6 TNF 8666946 1597673 Positive_regulation MAPK6 TNFSF10 22462553 1230465 Positive_regulation MAPK6 TNFSF10 22719861 2653328 Positive_regulation MAPK7 ALOX5 22363611 2601208 Positive_regulation MAPK7 ALOX5 25025775 2989418 Positive_regulation MAPK7 ANGPT1 24013716 2842156 Positive_regulation MAPK7 ANGPT1 25329960 3017114 Positive_regulation MAPK7 ARSA 20339548 2444467 Positive_regulation MAPK7 ARSA 20339548 2444495 Positive_regulation MAPK7 CAPN8 24416390 2908433 Positive_regulation MAPK7 CCND1 22220184 1156000 Positive_regulation MAPK7 CCND1 25047753 240953 Positive_regulation MAPK7 CD14 20011115 3045937 Positive_regulation MAPK7 CD14 21387014 2506190 Positive_regulation MAPK7 CD14 24376813 2902238 Positive_regulation MAPK7 CHI3L1 23755018 961389 Positive_regulation MAPK7 CHI3L1 23972995 609005 Positive_regulation MAPK7 CHI3L1 23972995 609006 Positive_regulation MAPK7 CHI3L1 24729664 1758075 Positive_regulation MAPK7 CTGF 22135505 3128252 Positive_regulation MAPK7 CTGF 22918238 541778 Positive_regulation MAPK7 CTGF 23383241 2749653 Positive_regulation MAPK7 CTGF 23946690 1716071 Positive_regulation MAPK7 CYP24A1 22577546 1139595 Positive_regulation MAPK7 EDN2 12369712 1077824 Positive_regulation MAPK7 EDN2 24695532 2948248 Positive_regulation MAPK7 EPHB2 11783444 2001216 Positive_regulation MAPK7 EPHB2 18578886 356873 Positive_regulation MAPK7 EPHB2 19047466 1361984 Positive_regulation MAPK7 EPHB2 19047466 1361985 Positive_regulation MAPK7 EPHB2 19047466 1361986 Positive_regulation MAPK7 EPHB2 19047466 1362111 Positive_regulation MAPK7 EPHB2 19047466 1362112 Positive_regulation MAPK7 EPHB2 19047466 1362141 Positive_regulation MAPK7 EPHB2 19107595 1027498 Positive_regulation MAPK7 EPHB2 19357636 1902968 Positive_regulation MAPK7 EPHB2 20100173 212594 Positive_regulation MAPK7 EPHB2 21488184 3232798 Positive_regulation MAPK7 EPHB2 21488184 3232799 Positive_regulation MAPK7 EPHB2 21876711 813190 Positive_regulation MAPK7 EPHB2 22294469 135340 Positive_regulation MAPK7 EPHB2 22507553 1661747 Positive_regulation MAPK7 EPHB2 22675451 2648352 Positive_regulation MAPK7 EPHB2 22719861 2653331 Positive_regulation MAPK7 EPHB2 22723883 2655017 Positive_regulation MAPK7 EPHB2 22741533 381935 Positive_regulation MAPK7 EPHB2 22951718 1631196 Positive_regulation MAPK7 EPHB2 23383241 2749654 Positive_regulation MAPK7 EPHB2 23388501 1920514 Positive_regulation MAPK7 EPHB2 23738323 181935 Positive_regulation MAPK7 EPHB2 23826208 2811469 Positive_regulation MAPK7 EPHB2 24098984 1726348 Positive_regulation MAPK7 EPHB2 24823621 1624671 Positive_regulation MAPK7 EPHB2 24885161 396510 Positive_regulation MAPK7 EPHB2 24978597 2985611 Positive_regulation MAPK7 EPHB2 25299961 174478 Positive_regulation MAPK7 F2R 21378407 2175462 Positive_regulation MAPK7 F2R 21760880 2535533 Positive_regulation MAPK7 F2R 21760880 2535795 Positive_regulation MAPK7 F2R 21845431 3158103 Positive_regulation MAPK7 F2R 24215724 538279 Positive_regulation MAPK7 F2R 24278684 3150072 Positive_regulation MAPK7 F2R 24743392 2955228 Positive_regulation MAPK7 F2R 24743392 2955360 Positive_regulation MAPK7 F2R 24743392 2955417 Positive_regulation MAPK7 F2R 24860547 880694 Positive_regulation MAPK7 FAS 11259103 418463 Positive_regulation MAPK7 FAS 14970175 1531127 Positive_regulation MAPK7 FAS 19487421 1555070 Positive_regulation MAPK7 FAS 19564926 1055593 Positive_regulation MAPK7 FAS 20573240 1856433 Positive_regulation MAPK7 FAS 20573240 1856459 Positive_regulation MAPK7 FAS 21477291 527148 Positive_regulation MAPK7 FAS 21975294 552724 Positive_regulation MAPK7 FAS 21975294 552725 Positive_regulation MAPK7 FAS 21975294 552726 Positive_regulation MAPK7 FAS 21975294 552727 Positive_regulation MAPK7 FAS 21975294 552728 Positive_regulation MAPK7 FAS 21975294 552729 Positive_regulation MAPK7 FAS 21975294 552813 Positive_regulation MAPK7 FAS 21975294 552814 Positive_regulation MAPK7 FAS 21975294 552815 Positive_regulation MAPK7 FAS 21975294 552934 Positive_regulation MAPK7 FAS 21975294 552935 Positive_regulation MAPK7 FAS 21975294 552936 Positive_regulation MAPK7 FAS 21975294 553135 Positive_regulation MAPK7 FAS 23029562 2698775 Positive_regulation MAPK7 FAS 23029562 2698796 Positive_regulation MAPK7 FAS 23852022 1108465 Positive_regulation MAPK7 FAS 25196936 1730939 Positive_regulation MAPK7 FAS 9362518 1464821 Positive_regulation MAPK7 FBXO32 22082477 682655 Positive_regulation MAPK7 FBXO32 23046544 3161242 Positive_regulation MAPK7 FOXO1 20375467 26985 Positive_regulation MAPK7 GLP1R 23536825 2773066 Positive_regulation MAPK7 GPR115 22570668 635797 Positive_regulation MAPK7 GPR132 22570668 635786 Positive_regulation MAPK7 GPR87 22570668 635866 Positive_regulation MAPK7 HBEGF 15817123 1844621 Positive_regulation MAPK7 HBEGF 15817123 1844699 Positive_regulation MAPK7 HBEGF 22259731 1146106 Positive_regulation MAPK7 HBEGF 22792252 2661664 Positive_regulation MAPK7 HBEGF PMC3760629 1606207 Positive_regulation MAPK7 IFI27 11560992 1520890 Positive_regulation MAPK7 ITGB2 21206905 2491120 Positive_regulation MAPK7 ITGB2 23508943 906524 Positive_regulation MAPK7 MAP2K6 10330402 1246246 Positive_regulation MAPK7 MAP2K6 10737387 417019 Positive_regulation MAPK7 MAP2K6 11259103 418465 Positive_regulation MAPK7 MAP2K6 12117640 791109 Positive_regulation MAPK7 MAP2K6 14981092 1306497 Positive_regulation MAPK7 MAP2K6 16048647 3105359 Positive_regulation MAPK7 MAP2K6 17020917 2023121 Positive_regulation MAPK7 MAP2K6 17020917 2023129 Positive_regulation MAPK7 MAP2K6 17525795 2014002 Positive_regulation MAPK7 MAP2K6 17576777 1546484 Positive_regulation MAPK7 MAP2K6 18955270 811033 Positive_regulation MAPK7 MAP2K6 19159010 1055163 Positive_regulation MAPK7 MAP2K6 19159010 1055381 Positive_regulation MAPK7 MAP2K6 19390590 2415275 Positive_regulation MAPK7 MAP2K6 19426550 282574 Positive_regulation MAPK7 MAP2K6 20221403 2442601 Positive_regulation MAPK7 MAP2K6 20463961 2449795 Positive_regulation MAPK7 MAP2K6 20802223 2253144 Positive_regulation MAPK7 MAP2K6 20955562 120571 Positive_regulation MAPK7 MAP2K6 20955562 120663 Positive_regulation MAPK7 MAP2K6 21345249 121680 Positive_regulation MAPK7 MAP2K6 22028883 2564957 Positive_regulation MAPK7 MAP2K6 22159586 600604 Positive_regulation MAPK7 MAP2K6 22245064 613606 Positive_regulation MAPK7 MAP2K6 22359624 2598562 Positive_regulation MAPK7 MAP2K6 22415879 722037 Positive_regulation MAPK7 MAP2K6 22415879 722367 Positive_regulation MAPK7 MAP2K6 22529896 2620607 Positive_regulation MAPK7 MAP2K6 22740774 490740 Positive_regulation MAPK7 MAP2K6 22870983 288773 Positive_regulation MAPK7 MAP2K6 22870983 288912 Positive_regulation MAPK7 MAP2K6 22870983 289021 Positive_regulation MAPK7 MAP2K6 23115639 2711465 Positive_regulation MAPK7 MAP2K6 23166686 2718525 Positive_regulation MAPK7 MAP2K6 23535559 1721202 Positive_regulation MAPK7 MAP2K6 23772401 852671 Positive_regulation MAPK7 MAP2K6 23936348 2830157 Positive_regulation MAPK7 MAP2K6 24566153 1124375 Positive_regulation MAPK7 MAP2K6 24792484 2960501 Positive_regulation MAPK7 MAP2K6 25364728 861787 Positive_regulation MAPK7 MAP2K6 25479605 3032573 Positive_regulation MAPK7 MAP2K6 9700154 1469490 Positive_regulation MAPK7 MIP 19781090 1625744 Positive_regulation MAPK7 MIP 21977329 1082353 Positive_regulation MAPK7 MMP28 18778487 384795 Positive_regulation MAPK7 MMP28 23688423 314008 Positive_regulation MAPK7 MMP28 23688423 314471 Positive_regulation MAPK7 MMP28 23878609 821935 Positive_regulation MAPK7 MMP28 25520932 203186 Positive_regulation MAPK7 MMP7 23688423 314023 Positive_regulation MAPK7 MMP7 23688423 314487 Positive_regulation MAPK7 MMP7 23878609 821951 Positive_regulation MAPK7 MMP7 25520932 203201 Positive_regulation MAPK7 MUC16 17029558 2303129 Positive_regulation MAPK7 MUC16 23694968 3135931 Positive_regulation MAPK7 NGFR 22880054 2673877 Positive_regulation MAPK7 NR2F1 24906407 273654 Positive_regulation MAPK7 OXTR 22190926 1072842 Positive_regulation MAPK7 PLAU 23724131 2799133 Positive_regulation MAPK7 PLAU 23724131 2799391 Positive_regulation MAPK7 PTGER2 25327961 216580 Positive_regulation MAPK7 RCAN1 19124655 1553358 Positive_regulation MAPK7 RCAN1 19124655 1553478 Positive_regulation MAPK7 RGS2 24743392 2955361 Positive_regulation MAPK7 S100B 22276098 2589833 Positive_regulation MAPK7 S100B 23259641 1665770 Positive_regulation MAPK7 S100B 23259641 1665784 Positive_regulation MAPK7 S100B 23259641 1665798 Positive_regulation MAPK7 SCGB3A1 22289642 335851 Positive_regulation MAPK7 SLC6A2 18509476 2389904 Positive_regulation MAPK7 SPHK1 16847102 1331312 Positive_regulation MAPK7 SPHK1 20498849 2451139 Positive_regulation MAPK7 SPHK1 20498849 2451174 Positive_regulation MAPK7 TLR7 19043549 3042433 Positive_regulation MAPK7 TLR7 19043549 3042577 Positive_regulation MAPK7 TLR7 19371402 734001 Positive_regulation MAPK7 TLR7 19685283 495442 Positive_regulation MAPK7 TLR7 20832340 1040240 Positive_regulation MAPK7 TLR7 21633096 1992467 Positive_regulation MAPK7 TLR7 21743791 1028495 Positive_regulation MAPK7 TLR7 21943110 2231397 Positive_regulation MAPK7 TLR7 22110382 1058373 Positive_regulation MAPK7 TLR7 22216226 2584878 Positive_regulation MAPK7 TLR7 22829768 3058439 Positive_regulation MAPK7 TLR7 23202320 3184730 Positive_regulation MAPK7 TLR7 23305364 694030 Positive_regulation MAPK7 TLR7 23521892 3215368 Positive_regulation MAPK7 TLR7 23603814 1962917 Positive_regulation MAPK7 TLR7 23760366 2211962 Positive_regulation MAPK7 TLR7 23840534 2815037 Positive_regulation MAPK7 TLR7 24489933 2916871 Positive_regulation MAPK7 TLR7 24603716 2932111 Positive_regulation MAPK7 TLR7 24772440 189766 Positive_regulation MAPK7 TLR7 24800851 2961084 Positive_regulation MAPK7 TLR7 25177436 647026 Positive_regulation MAPK7 TNF 11015442 1517398 Positive_regulation MAPK7 TNF 11015442 1517427 Positive_regulation MAPK7 TNF 11015442 1517440 Positive_regulation MAPK7 TNF 11015442 1517453 Positive_regulation MAPK7 TNF 14613529 3095430 Positive_regulation MAPK7 TNF 15157285 277606 Positive_regulation MAPK7 TNF 15642133 102191 Positive_regulation MAPK7 TNF 15781582 1535132 Positive_regulation MAPK7 TNF 15841081 425544 Positive_regulation MAPK7 TNF 15841081 425545 Positive_regulation MAPK7 TNF 15841081 425876 Positive_regulation MAPK7 TNF 16100442 1634595 Positive_regulation MAPK7 TNF 16100442 1634636 Positive_regulation MAPK7 TNF 16207331 104247 Positive_regulation MAPK7 TNF 16207331 104289 Positive_regulation MAPK7 TNF 16207331 104290 Positive_regulation MAPK7 TNF 16207331 104338 Positive_regulation MAPK7 TNF 16207331 104339 Positive_regulation MAPK7 TNF 16207331 104359 Positive_regulation MAPK7 TNF 16207342 104523 Positive_regulation MAPK7 TNF 16207342 104575 Positive_regulation MAPK7 TNF 17283208 1544263 Positive_regulation MAPK7 TNF 17342245 810735 Positive_regulation MAPK7 TNF 18096615 2032358 Positive_regulation MAPK7 TNF 18404427 3087190 Positive_regulation MAPK7 TNF 18410682 110446 Positive_regulation MAPK7 TNF 19343193 1746550 Positive_regulation MAPK7 TNF 19442267 1696275 Positive_regulation MAPK7 TNF 19707336 175509 Positive_regulation MAPK7 TNF 19723340 1227353 Positive_regulation MAPK7 TNF 19723340 1227368 Positive_regulation MAPK7 TNF 19723340 1227383 Positive_regulation MAPK7 TNF 20157567 26233 Positive_regulation MAPK7 TNF 20157567 26453 Positive_regulation MAPK7 TNF 20308428 1373866 Positive_regulation MAPK7 TNF 20418897 9893 Positive_regulation MAPK7 TNF 20529221 34782 Positive_regulation MAPK7 TNF 20615213 119651 Positive_regulation MAPK7 TNF 20644550 10427 Positive_regulation MAPK7 TNF 20844314 27780 Positive_regulation MAPK7 TNF 20844314 28243 Positive_regulation MAPK7 TNF 20871620 11953 Positive_regulation MAPK7 TNF 21386087 718544 Positive_regulation MAPK7 TNF 21423395 955241 Positive_regulation MAPK7 TNF 21485745 734920 Positive_regulation MAPK7 TNF 21572963 2520304 Positive_regulation MAPK7 TNF 21837268 1082188 Positive_regulation MAPK7 TNF 21867555 1659584 Positive_regulation MAPK7 TNF 21871121 1659634 Positive_regulation MAPK7 TNF 22082477 682563 Positive_regulation MAPK7 TNF 22194685 3055235 Positive_regulation MAPK7 TNF 22802702 1714262 Positive_regulation MAPK7 TNF 22802702 1714275 Positive_regulation MAPK7 TNF 22802702 1714308 Positive_regulation MAPK7 TNF 22988345 1750565 Positive_regulation MAPK7 TNF 23028407 2219789 Positive_regulation MAPK7 TNF 23071583 2703153 Positive_regulation MAPK7 TNF 23071583 2703174 Positive_regulation MAPK7 TNF 23152905 2716812 Positive_regulation MAPK7 TNF 23190711 1665182 Positive_regulation MAPK7 TNF 23282009 1665859 Positive_regulation MAPK7 TNF 23326019 1751338 Positive_regulation MAPK7 TNF 23331383 1675517 Positive_regulation MAPK7 TNF 23533994 180663 Positive_regulation MAPK7 TNF 23626383 1046763 Positive_regulation MAPK7 TNF 23671702 2792498 Positive_regulation MAPK7 TNF 23688423 314466 Positive_regulation MAPK7 TNF 23690670 1752168 Positive_regulation MAPK7 TNF 23755184 2801843 Positive_regulation MAPK7 TNF 23784308 606120 Positive_regulation MAPK7 TNF 23784308 606144 Positive_regulation MAPK7 TNF 23967215 2835011 Positive_regulation MAPK7 TNF 23977119 2838455 Positive_regulation MAPK7 TNF 24008729 565167 Positive_regulation MAPK7 TNF 24008729 565515 Positive_regulation MAPK7 TNF 24024042 2003216 Positive_regulation MAPK7 TNF 24069158 2851413 Positive_regulation MAPK7 TNF 24069158 2851556 Positive_regulation MAPK7 TNF 24069158 2851557 Positive_regulation MAPK7 TNF 24086560 2854632 Positive_regulation MAPK7 TNF 24101950 2227327 Positive_regulation MAPK7 TNF 24244348 2879501 Positive_regulation MAPK7 TNF 24266983 240394 Positive_regulation MAPK7 TNF 24285913 737685 Positive_regulation MAPK7 TNF 24307884 3155532 Positive_regulation MAPK7 TNF 24377382 3225651 Positive_regulation MAPK7 TNF 24423080 538879 Positive_regulation MAPK7 TNF 24460683 240494 Positive_regulation MAPK7 TNF 24487321 1959844 Positive_regulation MAPK7 TNF 24489443 1757411 Positive_regulation MAPK7 TNF 24502696 1233047 Positive_regulation MAPK7 TNF 24502696 1233070 Positive_regulation MAPK7 TNF 24502696 1233126 Positive_regulation MAPK7 TNF 24502696 1233127 Positive_regulation MAPK7 TNF 24502696 1233172 Positive_regulation MAPK7 TNF 24502696 1233173 Positive_regulation MAPK7 TNF 24502696 1233226 Positive_regulation MAPK7 TNF 24502696 1233276 Positive_regulation MAPK7 TNF 24502696 1233300 Positive_regulation MAPK7 TNF 24587316 2929418 Positive_regulation MAPK7 TNF 24614867 2933189 Positive_regulation MAPK7 TNF 24616552 1757564 Positive_regulation MAPK7 TNF 24707477 188353 Positive_regulation MAPK7 TNF 24707477 188441 Positive_regulation MAPK7 TNF 24707477 188471 Positive_regulation MAPK7 TNF 24758719 1483155 Positive_regulation MAPK7 TNF 24773466 34211 Positive_regulation MAPK7 TNF 24821138 2969104 Positive_regulation MAPK7 TNF 24886088 347474 Positive_regulation MAPK7 TNF 25090227 2995089 Positive_regulation MAPK7 TNF 25110549 2229794 Positive_regulation MAPK7 TNF 25114952 3156820 Positive_regulation MAPK7 TNF 25114952 3156836 Positive_regulation MAPK7 TNF 25152756 826705 Positive_regulation MAPK7 TNF 25196285 3224118 Positive_regulation MAPK7 TNF 25206704 2005731 Positive_regulation MAPK7 TNF 25435878 1074938 Positive_regulation MAPK7 TNF 7525608 1436383 Positive_regulation MAPK7 TNF 7530764 1590004 Positive_regulation MAPK7 TNF 8562342 445253 Positive_regulation MAPK7 TNF 8666946 1597674 Positive_regulation MAPK7 TNFSF10 22462553 1230466 Positive_regulation MAPK7 TNFSF10 22719861 2653330 Positive_regulation MAPK7 WNT7A 18509496 3072395 Positive_regulation MAPK7 WNT7A 24204697 2873401 Positive_regulation MAPK7 WNT7A 24204697 2873402 Positive_regulation MAPK7 WNT7A 24204697 2873492 Positive_regulation MAPK7 WNT7A 24204697 2873496 Positive_regulation MAPK7 WNT7A 24204697 2873500 Positive_regulation MAPK7 WNT7A 24204697 2873503 Positive_regulation MAPK8 ALOX5 22363611 2601209 Positive_regulation MAPK8 ALOX5 25025775 2989419 Positive_regulation MAPK8 ANGPT1 24013716 2842157 Positive_regulation MAPK8 ANGPT1 25329960 3017117 Positive_regulation MAPK8 ARSA 20339548 2444468 Positive_regulation MAPK8 ARSA 20339548 2444496 Positive_regulation MAPK8 CAPN8 24416390 2908447 Positive_regulation MAPK8 CCND1 22220184 1156001 Positive_regulation MAPK8 CCND1 25047753 240961 Positive_regulation MAPK8 CD14 20011115 3045938 Positive_regulation MAPK8 CD14 21387014 2506191 Positive_regulation MAPK8 CD14 24376813 2902241 Positive_regulation MAPK8 CHI3L1 23755018 961392 Positive_regulation MAPK8 CHI3L1 23972995 609007 Positive_regulation MAPK8 CHI3L1 23972995 609008 Positive_regulation MAPK8 CHI3L1 24729664 1758076 Positive_regulation MAPK8 CTGF 22135505 3128253 Positive_regulation MAPK8 CTGF 22918238 541779 Positive_regulation MAPK8 CTGF 23383241 2749655 Positive_regulation MAPK8 CTGF 23946690 1716072 Positive_regulation MAPK8 CYP24A1 22577546 1139596 Positive_regulation MAPK8 EDN2 12369712 1077827 Positive_regulation MAPK8 EDN2 24695532 2948251 Positive_regulation MAPK8 EPHB2 11783444 2001217 Positive_regulation MAPK8 EPHB2 18578886 356874 Positive_regulation MAPK8 EPHB2 19047466 1361987 Positive_regulation MAPK8 EPHB2 19047466 1361988 Positive_regulation MAPK8 EPHB2 19047466 1361989 Positive_regulation MAPK8 EPHB2 19047466 1362113 Positive_regulation MAPK8 EPHB2 19047466 1362114 Positive_regulation MAPK8 EPHB2 19047466 1362142 Positive_regulation MAPK8 EPHB2 19107595 1027500 Positive_regulation MAPK8 EPHB2 19357636 1902970 Positive_regulation MAPK8 EPHB2 20100173 212595 Positive_regulation MAPK8 EPHB2 20939017 1237857 Positive_regulation MAPK8 EPHB2 21488184 3232800 Positive_regulation MAPK8 EPHB2 21488184 3232801 Positive_regulation MAPK8 EPHB2 21562587 551910 Positive_regulation MAPK8 EPHB2 21876711 813191 Positive_regulation MAPK8 EPHB2 22294469 135341 Positive_regulation MAPK8 EPHB2 22507553 1661753 Positive_regulation MAPK8 EPHB2 22675451 2648355 Positive_regulation MAPK8 EPHB2 22719861 2653333 Positive_regulation MAPK8 EPHB2 22723883 2655018 Positive_regulation MAPK8 EPHB2 22741533 381937 Positive_regulation MAPK8 EPHB2 22951718 1631197 Positive_regulation MAPK8 EPHB2 23383241 2749656 Positive_regulation MAPK8 EPHB2 23388501 1920515 Positive_regulation MAPK8 EPHB2 23738323 181937 Positive_regulation MAPK8 EPHB2 23826208 2811470 Positive_regulation MAPK8 EPHB2 24098984 1726349 Positive_regulation MAPK8 EPHB2 24823621 1624672 Positive_regulation MAPK8 EPHB2 24885161 396511 Positive_regulation MAPK8 EPHB2 24978597 2985612 Positive_regulation MAPK8 EPHB2 25299961 174479 Positive_regulation MAPK8 F2R 21378407 2175463 Positive_regulation MAPK8 F2R 21760880 2535539 Positive_regulation MAPK8 F2R 21760880 2535801 Positive_regulation MAPK8 F2R 21845431 3158104 Positive_regulation MAPK8 F2R 24215724 538280 Positive_regulation MAPK8 F2R 24278684 3150073 Positive_regulation MAPK8 F2R 24743392 2955231 Positive_regulation MAPK8 F2R 24743392 2955363 Positive_regulation MAPK8 F2R 24743392 2955418 Positive_regulation MAPK8 F2R 24860547 880697 Positive_regulation MAPK8 FAS 11259103 418466 Positive_regulation MAPK8 FAS 14970175 1531128 Positive_regulation MAPK8 FAS 16818723 1330944 Positive_regulation MAPK8 FAS 19487421 1555072 Positive_regulation MAPK8 FAS 19564926 1055594 Positive_regulation MAPK8 FAS 20573240 1856434 Positive_regulation MAPK8 FAS 20573240 1856460 Positive_regulation MAPK8 FAS 21477291 527149 Positive_regulation MAPK8 FAS 21975294 552730 Positive_regulation MAPK8 FAS 21975294 552731 Positive_regulation MAPK8 FAS 21975294 552732 Positive_regulation MAPK8 FAS 21975294 552733 Positive_regulation MAPK8 FAS 21975294 552734 Positive_regulation MAPK8 FAS 21975294 552735 Positive_regulation MAPK8 FAS 21975294 552816 Positive_regulation MAPK8 FAS 21975294 552817 Positive_regulation MAPK8 FAS 21975294 552818 Positive_regulation MAPK8 FAS 21975294 552940 Positive_regulation MAPK8 FAS 21975294 552941 Positive_regulation MAPK8 FAS 21975294 552942 Positive_regulation MAPK8 FAS 21975294 553149 Positive_regulation MAPK8 FAS 22235182 3152456 Positive_regulation MAPK8 FAS 23029562 2698776 Positive_regulation MAPK8 FAS 23029562 2698797 Positive_regulation MAPK8 FAS 23852022 1108466 Positive_regulation MAPK8 FAS 25196936 1730941 Positive_regulation MAPK8 FAS 9362518 1464823 Positive_regulation MAPK8 FBXO32 22082477 682658 Positive_regulation MAPK8 FBXO32 23046544 3161243 Positive_regulation MAPK8 FOXO1 20375467 26989 Positive_regulation MAPK8 GLP1R 23536825 2773067 Positive_regulation MAPK8 GPR115 22570668 635890 Positive_regulation MAPK8 GPR132 22570668 635879 Positive_regulation MAPK8 GPR87 22570668 635959 Positive_regulation MAPK8 HBEGF 15817123 1844624 Positive_regulation MAPK8 HBEGF 15817123 1844701 Positive_regulation MAPK8 HBEGF 22259731 1146107 Positive_regulation MAPK8 HBEGF 22792252 2661665 Positive_regulation MAPK8 HBEGF PMC3760629 1606208 Positive_regulation MAPK8 IFI27 11560992 1520892 Positive_regulation MAPK8 ITGB2 21206905 2491122 Positive_regulation MAPK8 ITGB2 23508943 906526 Positive_regulation MAPK8 MAP2K6 10330402 1246248 Positive_regulation MAPK8 MAP2K6 10737387 417026 Positive_regulation MAPK8 MAP2K6 11259103 418468 Positive_regulation MAPK8 MAP2K6 12117640 791116 Positive_regulation MAPK8 MAP2K6 14981092 1306505 Positive_regulation MAPK8 MAP2K6 16048647 3105366 Positive_regulation MAPK8 MAP2K6 17525795 2014003 Positive_regulation MAPK8 MAP2K6 17567906 370626 Positive_regulation MAPK8 MAP2K6 17567906 370653 Positive_regulation MAPK8 MAP2K6 17576777 1546491 Positive_regulation MAPK8 MAP2K6 18955270 811046 Positive_regulation MAPK8 MAP2K6 19159010 1055164 Positive_regulation MAPK8 MAP2K6 19159010 1055382 Positive_regulation MAPK8 MAP2K6 19426550 282581 Positive_regulation MAPK8 MAP2K6 20221403 2442603 Positive_regulation MAPK8 MAP2K6 20463961 2449797 Positive_regulation MAPK8 MAP2K6 20802223 2253145 Positive_regulation MAPK8 MAP2K6 20955562 120575 Positive_regulation MAPK8 MAP2K6 20955562 120665 Positive_regulation MAPK8 MAP2K6 21345249 121687 Positive_regulation MAPK8 MAP2K6 22028883 2564964 Positive_regulation MAPK8 MAP2K6 22159586 600611 Positive_regulation MAPK8 MAP2K6 22245064 613613 Positive_regulation MAPK8 MAP2K6 22359624 2598570 Positive_regulation MAPK8 MAP2K6 22415879 722042 Positive_regulation MAPK8 MAP2K6 22415879 722372 Positive_regulation MAPK8 MAP2K6 22529896 2620614 Positive_regulation MAPK8 MAP2K6 22740774 490747 Positive_regulation MAPK8 MAP2K6 22870983 288774 Positive_regulation MAPK8 MAP2K6 22870983 288913 Positive_regulation MAPK8 MAP2K6 22870983 289022 Positive_regulation MAPK8 MAP2K6 23115639 2711467 Positive_regulation MAPK8 MAP2K6 23166686 2718532 Positive_regulation MAPK8 MAP2K6 23535559 1721211 Positive_regulation MAPK8 MAP2K6 23772401 852710 Positive_regulation MAPK8 MAP2K6 23936348 2830164 Positive_regulation MAPK8 MAP2K6 24566153 1124382 Positive_regulation MAPK8 MAP2K6 24792484 2960508 Positive_regulation MAPK8 MAP2K6 25364728 861789 Positive_regulation MAPK8 MAP2K6 25479605 3032580 Positive_regulation MAPK8 MAP2K6 9700154 1469497 Positive_regulation MAPK8 MIP 19781090 1625745 Positive_regulation MAPK8 MIP 21977329 1082354 Positive_regulation MAPK8 MMP28 18778487 384796 Positive_regulation MAPK8 MMP28 23688423 314030 Positive_regulation MAPK8 MMP28 23688423 314495 Positive_regulation MAPK8 MMP28 23878609 821958 Positive_regulation MAPK8 MMP28 25520932 203208 Positive_regulation MAPK8 MMP7 23688423 314045 Positive_regulation MAPK8 MMP7 23688423 314511 Positive_regulation MAPK8 MMP7 23878609 821974 Positive_regulation MAPK8 MMP7 25520932 203223 Positive_regulation MAPK8 MUC16 17029558 2303145 Positive_regulation MAPK8 MUC16 23694968 3135934 Positive_regulation MAPK8 NGFR 22880054 2673879 Positive_regulation MAPK8 NR2F1 24906407 273655 Positive_regulation MAPK8 OXTR 22190926 1072843 Positive_regulation MAPK8 PDE4B 23575688 1935974 Positive_regulation MAPK8 PLAU 23724131 2799135 Positive_regulation MAPK8 PLAU 23724131 2799392 Positive_regulation MAPK8 PTGER2 25327961 216581 Positive_regulation MAPK8 RCAN1 19124655 1553359 Positive_regulation MAPK8 RCAN1 19124655 1553479 Positive_regulation MAPK8 RGS2 24743392 2955364 Positive_regulation MAPK8 S100B 22276098 2589835 Positive_regulation MAPK8 S100B 23259641 1665771 Positive_regulation MAPK8 S100B 23259641 1665785 Positive_regulation MAPK8 S100B 23259641 1665799 Positive_regulation MAPK8 SCGB3A1 22289642 335852 Positive_regulation MAPK8 SLC38A3 20637111 1647220 Positive_regulation MAPK8 SLC6A2 18509476 2389905 Positive_regulation MAPK8 SPHK1 16847102 1331314 Positive_regulation MAPK8 SPHK1 20498849 2451140 Positive_regulation MAPK8 SPHK1 20498849 2451175 Positive_regulation MAPK8 TLR7 19043549 3042443 Positive_regulation MAPK8 TLR7 19043549 3042587 Positive_regulation MAPK8 TLR7 19371402 734011 Positive_regulation MAPK8 TLR7 19685283 495452 Positive_regulation MAPK8 TLR7 20832340 1040241 Positive_regulation MAPK8 TLR7 21633096 1992477 Positive_regulation MAPK8 TLR7 21743791 1028505 Positive_regulation MAPK8 TLR7 21943110 2231407 Positive_regulation MAPK8 TLR7 22110382 1058383 Positive_regulation MAPK8 TLR7 22216226 2584888 Positive_regulation MAPK8 TLR7 22829768 3058449 Positive_regulation MAPK8 TLR7 23202320 3184741 Positive_regulation MAPK8 TLR7 23305364 694040 Positive_regulation MAPK8 TLR7 23521892 3215378 Positive_regulation MAPK8 TLR7 23603814 1962929 Positive_regulation MAPK8 TLR7 23760366 2211972 Positive_regulation MAPK8 TLR7 23840534 2815047 Positive_regulation MAPK8 TLR7 24489933 2916881 Positive_regulation MAPK8 TLR7 24603716 2932121 Positive_regulation MAPK8 TLR7 24772440 189776 Positive_regulation MAPK8 TLR7 24800851 2961094 Positive_regulation MAPK8 TLR7 25177436 647036 Positive_regulation MAPK8 TLR7 25351958 153527 Positive_regulation MAPK8 TNF 11015442 1517400 Positive_regulation MAPK8 TNF 11015442 1517428 Positive_regulation MAPK8 TNF 11015442 1517441 Positive_regulation MAPK8 TNF 11015442 1517454 Positive_regulation MAPK8 TNF 14577832 3095125 Positive_regulation MAPK8 TNF 14613529 3095431 Positive_regulation MAPK8 TNF 15157285 277607 Positive_regulation MAPK8 TNF 15642133 102193 Positive_regulation MAPK8 TNF 15781582 1535133 Positive_regulation MAPK8 TNF 15841081 425546 Positive_regulation MAPK8 TNF 15841081 425547 Positive_regulation MAPK8 TNF 15841081 425877 Positive_regulation MAPK8 TNF 16100442 1634607 Positive_regulation MAPK8 TNF 16100442 1634637 Positive_regulation MAPK8 TNF 16207331 104248 Positive_regulation MAPK8 TNF 16207331 104291 Positive_regulation MAPK8 TNF 16207331 104292 Positive_regulation MAPK8 TNF 16207331 104341 Positive_regulation MAPK8 TNF 16207331 104342 Positive_regulation MAPK8 TNF 16207331 104360 Positive_regulation MAPK8 TNF 16207342 104524 Positive_regulation MAPK8 TNF 16207342 104576 Positive_regulation MAPK8 TNF 17283208 1544264 Positive_regulation MAPK8 TNF 17342245 810736 Positive_regulation MAPK8 TNF 17567906 370620 Positive_regulation MAPK8 TNF 17567906 370632 Positive_regulation MAPK8 TNF 18096615 2032360 Positive_regulation MAPK8 TNF 18404427 3087191 Positive_regulation MAPK8 TNF 18410682 110447 Positive_regulation MAPK8 TNF 18591389 706360 Positive_regulation MAPK8 TNF 19343193 1746551 Positive_regulation MAPK8 TNF 19442267 1696276 Positive_regulation MAPK8 TNF 19707336 175511 Positive_regulation MAPK8 TNF 19723340 1227354 Positive_regulation MAPK8 TNF 19723340 1227369 Positive_regulation MAPK8 TNF 19723340 1227384 Positive_regulation MAPK8 TNF 19723340 1227385 Positive_regulation MAPK8 TNF 20157567 26236 Positive_regulation MAPK8 TNF 20157567 26454 Positive_regulation MAPK8 TNF 20308428 1373867 Positive_regulation MAPK8 TNF 20418897 9894 Positive_regulation MAPK8 TNF 20529221 34783 Positive_regulation MAPK8 TNF 20615213 119654 Positive_regulation MAPK8 TNF 20644550 10428 Positive_regulation MAPK8 TNF 20844314 27781 Positive_regulation MAPK8 TNF 20844314 28244 Positive_regulation MAPK8 TNF 20871620 11954 Positive_regulation MAPK8 TNF 21386087 718546 Positive_regulation MAPK8 TNF 21423395 955243 Positive_regulation MAPK8 TNF 21485745 734922 Positive_regulation MAPK8 TNF 21492465 360641 Positive_regulation MAPK8 TNF 21572963 2520305 Positive_regulation MAPK8 TNF 21645321 395476 Positive_regulation MAPK8 TNF 21837268 1082189 Positive_regulation MAPK8 TNF 21867555 1659585 Positive_regulation MAPK8 TNF 21871121 1659635 Positive_regulation MAPK8 TNF 22082477 682565 Positive_regulation MAPK8 TNF 22194685 3055236 Positive_regulation MAPK8 TNF 22802702 1714263 Positive_regulation MAPK8 TNF 22802702 1714276 Positive_regulation MAPK8 TNF 22802702 1714309 Positive_regulation MAPK8 TNF 22899934 1068824 Positive_regulation MAPK8 TNF 22988345 1750566 Positive_regulation MAPK8 TNF 23028407 2219793 Positive_regulation MAPK8 TNF 23071583 2703154 Positive_regulation MAPK8 TNF 23071583 2703175 Positive_regulation MAPK8 TNF 23125866 637088 Positive_regulation MAPK8 TNF 23152905 2716813 Positive_regulation MAPK8 TNF 23190711 1665183 Positive_regulation MAPK8 TNF 23282009 1665860 Positive_regulation MAPK8 TNF 23326019 1751339 Positive_regulation MAPK8 TNF 23331383 1675519 Positive_regulation MAPK8 TNF 23533994 180664 Positive_regulation MAPK8 TNF 23626383 1046765 Positive_regulation MAPK8 TNF 23671702 2792499 Positive_regulation MAPK8 TNF 23671702 2792510 Positive_regulation MAPK8 TNF 23688423 314490 Positive_regulation MAPK8 TNF 23690670 1752170 Positive_regulation MAPK8 TNF 23755184 2801844 Positive_regulation MAPK8 TNF 23784308 606121 Positive_regulation MAPK8 TNF 23784308 606146 Positive_regulation MAPK8 TNF 23967215 2835014 Positive_regulation MAPK8 TNF 23977119 2838456 Positive_regulation MAPK8 TNF 24008729 565168 Positive_regulation MAPK8 TNF 24008729 565516 Positive_regulation MAPK8 TNF 24024042 2003217 Positive_regulation MAPK8 TNF 24069158 2851418 Positive_regulation MAPK8 TNF 24069158 2851558 Positive_regulation MAPK8 TNF 24069158 2851559 Positive_regulation MAPK8 TNF 24069158 2851560 Positive_regulation MAPK8 TNF 24086560 2854633 Positive_regulation MAPK8 TNF 24086560 2854641 Positive_regulation MAPK8 TNF 24101950 2227328 Positive_regulation MAPK8 TNF 24244348 2879502 Positive_regulation MAPK8 TNF 24266983 240395 Positive_regulation MAPK8 TNF 24285913 737686 Positive_regulation MAPK8 TNF 24307884 3155533 Positive_regulation MAPK8 TNF 24377382 3225652 Positive_regulation MAPK8 TNF 24423080 538880 Positive_regulation MAPK8 TNF 24460683 240495 Positive_regulation MAPK8 TNF 24487321 1959845 Positive_regulation MAPK8 TNF 24489443 1757412 Positive_regulation MAPK8 TNF 24502696 1233048 Positive_regulation MAPK8 TNF 24502696 1233071 Positive_regulation MAPK8 TNF 24502696 1233128 Positive_regulation MAPK8 TNF 24502696 1233129 Positive_regulation MAPK8 TNF 24502696 1233174 Positive_regulation MAPK8 TNF 24502696 1233175 Positive_regulation MAPK8 TNF 24502696 1233227 Positive_regulation MAPK8 TNF 24502696 1233278 Positive_regulation MAPK8 TNF 24502696 1233301 Positive_regulation MAPK8 TNF 24587316 2929419 Positive_regulation MAPK8 TNF 24614867 2933190 Positive_regulation MAPK8 TNF 24616552 1757565 Positive_regulation MAPK8 TNF 24651600 3066457 Positive_regulation MAPK8 TNF 24707477 188358 Positive_regulation MAPK8 TNF 24707477 188442 Positive_regulation MAPK8 TNF 24707477 188472 Positive_regulation MAPK8 TNF 24743742 573810 Positive_regulation MAPK8 TNF 24743742 573811 Positive_regulation MAPK8 TNF 24743742 573884 Positive_regulation MAPK8 TNF 24743742 573945 Positive_regulation MAPK8 TNF 24743742 574035 Positive_regulation MAPK8 TNF 24758719 1483156 Positive_regulation MAPK8 TNF 24773466 34212 Positive_regulation MAPK8 TNF 24821138 2969105 Positive_regulation MAPK8 TNF 24868497 3179299 Positive_regulation MAPK8 TNF 24886088 347475 Positive_regulation MAPK8 TNF 25002903 826399 Positive_regulation MAPK8 TNF 25090227 2995090 Positive_regulation MAPK8 TNF 25110549 2229795 Positive_regulation MAPK8 TNF 25114952 3156821 Positive_regulation MAPK8 TNF 25114952 3156837 Positive_regulation MAPK8 TNF 25152756 826707 Positive_regulation MAPK8 TNF 25196285 3224119 Positive_regulation MAPK8 TNF 25206704 2005732 Positive_regulation MAPK8 TNF 25435878 1074939 Positive_regulation MAPK8 TNF 7525608 1436384 Positive_regulation MAPK8 TNF 7530764 1590005 Positive_regulation MAPK8 TNF 8562342 445254 Positive_regulation MAPK8 TNF 8666946 1597675 Positive_regulation MAPK8 TNFSF10 17177999 480412 Positive_regulation MAPK8 TNFSF10 21654829 552328 Positive_regulation MAPK8 TNFSF10 22462553 1230467 Positive_regulation MAPK8 TNFSF10 22719861 2653332 Positive_regulation MAPK8 TNFSF10 24667731 2939092 Positive_regulation MAPK8 TNFSF10 25259715 3010542 Positive_regulation MAPK8 TNFSF10 25276823 200303 Positive_regulation MAPK8IP1 TNFSF10 21237154 829093 Positive_regulation MAPK9 ALOX5 22363611 2601210 Positive_regulation MAPK9 ALOX5 25025775 2989420 Positive_regulation MAPK9 ANGPT1 24013716 2842158 Positive_regulation MAPK9 ANGPT1 25329960 3017120 Positive_regulation MAPK9 ARSA 20339548 2444469 Positive_regulation MAPK9 ARSA 20339548 2444497 Positive_regulation MAPK9 CAPN8 24416390 2908461 Positive_regulation MAPK9 CCND1 22220184 1156002 Positive_regulation MAPK9 CCND1 25047753 240969 Positive_regulation MAPK9 CD14 20011115 3045939 Positive_regulation MAPK9 CD14 21387014 2506192 Positive_regulation MAPK9 CD14 24376813 2902244 Positive_regulation MAPK9 CHI3L1 23755018 961395 Positive_regulation MAPK9 CHI3L1 23972995 609009 Positive_regulation MAPK9 CHI3L1 23972995 609010 Positive_regulation MAPK9 CHI3L1 24729664 1758077 Positive_regulation MAPK9 CTGF 22135505 3128254 Positive_regulation MAPK9 CTGF 22918238 541780 Positive_regulation MAPK9 CTGF 23383241 2749657 Positive_regulation MAPK9 CTGF 23946690 1716073 Positive_regulation MAPK9 CYP24A1 22577546 1139597 Positive_regulation MAPK9 EDN2 12369712 1077830 Positive_regulation MAPK9 EDN2 24695532 2948254 Positive_regulation MAPK9 EPHB2 11783444 2001218 Positive_regulation MAPK9 EPHB2 18578886 356875 Positive_regulation MAPK9 EPHB2 19047466 1361990 Positive_regulation MAPK9 EPHB2 19047466 1361991 Positive_regulation MAPK9 EPHB2 19047466 1361992 Positive_regulation MAPK9 EPHB2 19047466 1362115 Positive_regulation MAPK9 EPHB2 19047466 1362116 Positive_regulation MAPK9 EPHB2 19047466 1362143 Positive_regulation MAPK9 EPHB2 19107595 1027502 Positive_regulation MAPK9 EPHB2 19357636 1902972 Positive_regulation MAPK9 EPHB2 20100173 212596 Positive_regulation MAPK9 EPHB2 21488184 3232802 Positive_regulation MAPK9 EPHB2 21488184 3232803 Positive_regulation MAPK9 EPHB2 21876711 813192 Positive_regulation MAPK9 EPHB2 22294469 135342 Positive_regulation MAPK9 EPHB2 22507553 1661759 Positive_regulation MAPK9 EPHB2 22675451 2648358 Positive_regulation MAPK9 EPHB2 22719861 2653335 Positive_regulation MAPK9 EPHB2 22723883 2655019 Positive_regulation MAPK9 EPHB2 22741533 381939 Positive_regulation MAPK9 EPHB2 22951718 1631198 Positive_regulation MAPK9 EPHB2 23383241 2749658 Positive_regulation MAPK9 EPHB2 23388501 1920516 Positive_regulation MAPK9 EPHB2 23738323 181939 Positive_regulation MAPK9 EPHB2 23826208 2811471 Positive_regulation MAPK9 EPHB2 24098984 1726350 Positive_regulation MAPK9 EPHB2 24823621 1624673 Positive_regulation MAPK9 EPHB2 24885161 396512 Positive_regulation MAPK9 EPHB2 24978597 2985613 Positive_regulation MAPK9 EPHB2 25299961 174480 Positive_regulation MAPK9 F2R 21378407 2175464 Positive_regulation MAPK9 F2R 21760880 2535545 Positive_regulation MAPK9 F2R 21760880 2535807 Positive_regulation MAPK9 F2R 21845431 3158105 Positive_regulation MAPK9 F2R 24215724 538281 Positive_regulation MAPK9 F2R 24278684 3150074 Positive_regulation MAPK9 F2R 24743392 2955234 Positive_regulation MAPK9 F2R 24743392 2955366 Positive_regulation MAPK9 F2R 24743392 2955419 Positive_regulation MAPK9 F2R 24860547 880700 Positive_regulation MAPK9 FAS 11259103 418469 Positive_regulation MAPK9 FAS 14970175 1531129 Positive_regulation MAPK9 FAS 19487421 1555074 Positive_regulation MAPK9 FAS 19564926 1055595 Positive_regulation MAPK9 FAS 20573240 1856435 Positive_regulation MAPK9 FAS 20573240 1856461 Positive_regulation MAPK9 FAS 21477291 527150 Positive_regulation MAPK9 FAS 21975294 552736 Positive_regulation MAPK9 FAS 21975294 552737 Positive_regulation MAPK9 FAS 21975294 552738 Positive_regulation MAPK9 FAS 21975294 552739 Positive_regulation MAPK9 FAS 21975294 552740 Positive_regulation MAPK9 FAS 21975294 552741 Positive_regulation MAPK9 FAS 21975294 552819 Positive_regulation MAPK9 FAS 21975294 552820 Positive_regulation MAPK9 FAS 21975294 552821 Positive_regulation MAPK9 FAS 21975294 552946 Positive_regulation MAPK9 FAS 21975294 552947 Positive_regulation MAPK9 FAS 21975294 552948 Positive_regulation MAPK9 FAS 21975294 553163 Positive_regulation MAPK9 FAS 23029562 2698777 Positive_regulation MAPK9 FAS 23029562 2698798 Positive_regulation MAPK9 FAS 23852022 1108467 Positive_regulation MAPK9 FAS 25196936 1730943 Positive_regulation MAPK9 FAS 9362518 1464825 Positive_regulation MAPK9 FBXO32 22082477 682661 Positive_regulation MAPK9 FBXO32 23046544 3161244 Positive_regulation MAPK9 FOXO1 20375467 26993 Positive_regulation MAPK9 GLP1R 23536825 2773068 Positive_regulation MAPK9 GPR115 22570668 635983 Positive_regulation MAPK9 GPR132 22570668 635972 Positive_regulation MAPK9 GPR87 22570668 636052 Positive_regulation MAPK9 HBEGF 15817123 1844627 Positive_regulation MAPK9 HBEGF 15817123 1844703 Positive_regulation MAPK9 HBEGF 22259731 1146108 Positive_regulation MAPK9 HBEGF 22792252 2661666 Positive_regulation MAPK9 HBEGF PMC3760629 1606209 Positive_regulation MAPK9 IFI27 11560992 1520894 Positive_regulation MAPK9 ITGB2 21206905 2491124 Positive_regulation MAPK9 ITGB2 23508943 906528 Positive_regulation MAPK9 MAP2K6 10330402 1246250 Positive_regulation MAPK9 MAP2K6 10737387 417033 Positive_regulation MAPK9 MAP2K6 11259103 418471 Positive_regulation MAPK9 MAP2K6 12117640 791123 Positive_regulation MAPK9 MAP2K6 14981092 1306513 Positive_regulation MAPK9 MAP2K6 16048647 3105373 Positive_regulation MAPK9 MAP2K6 17525795 2014004 Positive_regulation MAPK9 MAP2K6 17576777 1546498 Positive_regulation MAPK9 MAP2K6 18955270 811059 Positive_regulation MAPK9 MAP2K6 19159010 1055165 Positive_regulation MAPK9 MAP2K6 19159010 1055383 Positive_regulation MAPK9 MAP2K6 19426550 282588 Positive_regulation MAPK9 MAP2K6 20221403 2442605 Positive_regulation MAPK9 MAP2K6 20463961 2449799 Positive_regulation MAPK9 MAP2K6 20802223 2253146 Positive_regulation MAPK9 MAP2K6 20955562 120579 Positive_regulation MAPK9 MAP2K6 20955562 120667 Positive_regulation MAPK9 MAP2K6 21345249 121694 Positive_regulation MAPK9 MAP2K6 22028883 2564971 Positive_regulation MAPK9 MAP2K6 22159586 600618 Positive_regulation MAPK9 MAP2K6 22245064 613620 Positive_regulation MAPK9 MAP2K6 22359624 2598578 Positive_regulation MAPK9 MAP2K6 22362764 1201301 Positive_regulation MAPK9 MAP2K6 22415879 722047 Positive_regulation MAPK9 MAP2K6 22415879 722377 Positive_regulation MAPK9 MAP2K6 22529896 2620621 Positive_regulation MAPK9 MAP2K6 22740774 490754 Positive_regulation MAPK9 MAP2K6 22870983 288775 Positive_regulation MAPK9 MAP2K6 22870983 288914 Positive_regulation MAPK9 MAP2K6 22870983 289023 Positive_regulation MAPK9 MAP2K6 23115639 2711469 Positive_regulation MAPK9 MAP2K6 23166686 2718539 Positive_regulation MAPK9 MAP2K6 23535559 1721220 Positive_regulation MAPK9 MAP2K6 23772401 852749 Positive_regulation MAPK9 MAP2K6 23936348 2830171 Positive_regulation MAPK9 MAP2K6 24566153 1124389 Positive_regulation MAPK9 MAP2K6 24792484 2960515 Positive_regulation MAPK9 MAP2K6 25364728 861791 Positive_regulation MAPK9 MAP2K6 25479605 3032587 Positive_regulation MAPK9 MAP2K6 9700154 1469504 Positive_regulation MAPK9 MIP 19781090 1625746 Positive_regulation MAPK9 MIP 21977329 1082355 Positive_regulation MAPK9 MMP28 18778487 384797 Positive_regulation MAPK9 MMP28 23688423 314052 Positive_regulation MAPK9 MMP28 23688423 314519 Positive_regulation MAPK9 MMP28 23878609 821981 Positive_regulation MAPK9 MMP28 25520932 203230 Positive_regulation MAPK9 MMP7 23688423 314067 Positive_regulation MAPK9 MMP7 23688423 314535 Positive_regulation MAPK9 MMP7 23878609 821997 Positive_regulation MAPK9 MMP7 25520932 203245 Positive_regulation MAPK9 MUC16 17029558 2303161 Positive_regulation MAPK9 MUC16 23694968 3135937 Positive_regulation MAPK9 NGFR 22880054 2673881 Positive_regulation MAPK9 NR2F1 24906407 273656 Positive_regulation MAPK9 OXTR 22190926 1072844 Positive_regulation MAPK9 PDE4B 23575688 1935965 Positive_regulation MAPK9 PDE4B 23575688 1935967 Positive_regulation MAPK9 PDE4B 23575688 1935975 Positive_regulation MAPK9 PLAU 23724131 2799137 Positive_regulation MAPK9 PLAU 23724131 2799393 Positive_regulation MAPK9 PTGER2 25327961 216582 Positive_regulation MAPK9 RCAN1 19124655 1553360 Positive_regulation MAPK9 RCAN1 19124655 1553480 Positive_regulation MAPK9 RGS2 24743392 2955367 Positive_regulation MAPK9 S100B 22276098 2589837 Positive_regulation MAPK9 S100B 23259641 1665772 Positive_regulation MAPK9 S100B 23259641 1665786 Positive_regulation MAPK9 S100B 23259641 1665800 Positive_regulation MAPK9 SCGB3A1 22289642 335853 Positive_regulation MAPK9 SLC6A2 18509476 2389906 Positive_regulation MAPK9 SPHK1 16847102 1331316 Positive_regulation MAPK9 SPHK1 20498849 2451141 Positive_regulation MAPK9 SPHK1 20498849 2451176 Positive_regulation MAPK9 TLR7 19043549 3042453 Positive_regulation MAPK9 TLR7 19043549 3042597 Positive_regulation MAPK9 TLR7 19371402 734021 Positive_regulation MAPK9 TLR7 19685283 495462 Positive_regulation MAPK9 TLR7 20832340 1040242 Positive_regulation MAPK9 TLR7 21633096 1992487 Positive_regulation MAPK9 TLR7 21743791 1028515 Positive_regulation MAPK9 TLR7 21943110 2231417 Positive_regulation MAPK9 TLR7 22110382 1058393 Positive_regulation MAPK9 TLR7 22216226 2584898 Positive_regulation MAPK9 TLR7 22829768 3058459 Positive_regulation MAPK9 TLR7 23202320 3184752 Positive_regulation MAPK9 TLR7 23305364 694050 Positive_regulation MAPK9 TLR7 23521892 3215388 Positive_regulation MAPK9 TLR7 23603814 1962941 Positive_regulation MAPK9 TLR7 23760366 2211982 Positive_regulation MAPK9 TLR7 23840534 2815057 Positive_regulation MAPK9 TLR7 24489933 2916891 Positive_regulation MAPK9 TLR7 24603716 2932131 Positive_regulation MAPK9 TLR7 24772440 189786 Positive_regulation MAPK9 TLR7 24800851 2961104 Positive_regulation MAPK9 TLR7 25177436 647046 Positive_regulation MAPK9 TNF 11015442 1517402 Positive_regulation MAPK9 TNF 11015442 1517429 Positive_regulation MAPK9 TNF 11015442 1517442 Positive_regulation MAPK9 TNF 11015442 1517455 Positive_regulation MAPK9 TNF 14613529 3095432 Positive_regulation MAPK9 TNF 15157285 277608 Positive_regulation MAPK9 TNF 15642133 102195 Positive_regulation MAPK9 TNF 15781582 1535134 Positive_regulation MAPK9 TNF 15841081 425548 Positive_regulation MAPK9 TNF 15841081 425549 Positive_regulation MAPK9 TNF 15841081 425878 Positive_regulation MAPK9 TNF 16100442 1634619 Positive_regulation MAPK9 TNF 16100442 1634638 Positive_regulation MAPK9 TNF 16207331 104249 Positive_regulation MAPK9 TNF 16207331 104293 Positive_regulation MAPK9 TNF 16207331 104294 Positive_regulation MAPK9 TNF 16207331 104344 Positive_regulation MAPK9 TNF 16207331 104345 Positive_regulation MAPK9 TNF 16207331 104361 Positive_regulation MAPK9 TNF 16207342 104525 Positive_regulation MAPK9 TNF 16207342 104577 Positive_regulation MAPK9 TNF 17283208 1544265 Positive_regulation MAPK9 TNF 17342245 810737 Positive_regulation MAPK9 TNF 18096615 2032362 Positive_regulation MAPK9 TNF 18404427 3087192 Positive_regulation MAPK9 TNF 18410682 110448 Positive_regulation MAPK9 TNF 19343193 1746552 Positive_regulation MAPK9 TNF 19442267 1696277 Positive_regulation MAPK9 TNF 19707336 175513 Positive_regulation MAPK9 TNF 19723340 1227355 Positive_regulation MAPK9 TNF 19723340 1227370 Positive_regulation MAPK9 TNF 19723340 1227386 Positive_regulation MAPK9 TNF 19723340 1227387 Positive_regulation MAPK9 TNF 20157567 26239 Positive_regulation MAPK9 TNF 20157567 26455 Positive_regulation MAPK9 TNF 20308428 1373868 Positive_regulation MAPK9 TNF 20418897 9895 Positive_regulation MAPK9 TNF 20529221 34784 Positive_regulation MAPK9 TNF 20615213 119657 Positive_regulation MAPK9 TNF 20644550 10429 Positive_regulation MAPK9 TNF 20844314 27782 Positive_regulation MAPK9 TNF 20844314 28245 Positive_regulation MAPK9 TNF 20871620 11955 Positive_regulation MAPK9 TNF 21386087 718548 Positive_regulation MAPK9 TNF 21423395 955245 Positive_regulation MAPK9 TNF 21485745 734924 Positive_regulation MAPK9 TNF 21572963 2520306 Positive_regulation MAPK9 TNF 21837268 1082190 Positive_regulation MAPK9 TNF 21867555 1659586 Positive_regulation MAPK9 TNF 21871121 1659636 Positive_regulation MAPK9 TNF 22082477 682567 Positive_regulation MAPK9 TNF 22194685 3055237 Positive_regulation MAPK9 TNF 22802702 1714264 Positive_regulation MAPK9 TNF 22802702 1714277 Positive_regulation MAPK9 TNF 22802702 1714310 Positive_regulation MAPK9 TNF 22988345 1750567 Positive_regulation MAPK9 TNF 23028407 2219797 Positive_regulation MAPK9 TNF 23071583 2703155 Positive_regulation MAPK9 TNF 23071583 2703176 Positive_regulation MAPK9 TNF 23152905 2716814 Positive_regulation MAPK9 TNF 23190711 1665184 Positive_regulation MAPK9 TNF 23282009 1665861 Positive_regulation MAPK9 TNF 23326019 1751340 Positive_regulation MAPK9 TNF 23331383 1675521 Positive_regulation MAPK9 TNF 23533994 180665 Positive_regulation MAPK9 TNF 23626383 1046767 Positive_regulation MAPK9 TNF 23671702 2792500 Positive_regulation MAPK9 TNF 23688423 314514 Positive_regulation MAPK9 TNF 23690670 1752172 Positive_regulation MAPK9 TNF 23755184 2801845 Positive_regulation MAPK9 TNF 23784308 606122 Positive_regulation MAPK9 TNF 23784308 606148 Positive_regulation MAPK9 TNF 23967215 2835017 Positive_regulation MAPK9 TNF 23977119 2838457 Positive_regulation MAPK9 TNF 24008729 565169 Positive_regulation MAPK9 TNF 24008729 565517 Positive_regulation MAPK9 TNF 24024042 2003218 Positive_regulation MAPK9 TNF 24069158 2851423 Positive_regulation MAPK9 TNF 24069158 2851561 Positive_regulation MAPK9 TNF 24069158 2851562 Positive_regulation MAPK9 TNF 24086560 2854634 Positive_regulation MAPK9 TNF 24101950 2227329 Positive_regulation MAPK9 TNF 24244348 2879503 Positive_regulation MAPK9 TNF 24266983 240396 Positive_regulation MAPK9 TNF 24285913 737687 Positive_regulation MAPK9 TNF 24307884 3155534 Positive_regulation MAPK9 TNF 24377382 3225653 Positive_regulation MAPK9 TNF 24423080 538881 Positive_regulation MAPK9 TNF 24460683 240496 Positive_regulation MAPK9 TNF 24487321 1959846 Positive_regulation MAPK9 TNF 24489443 1757413 Positive_regulation MAPK9 TNF 24502696 1233049 Positive_regulation MAPK9 TNF 24502696 1233072 Positive_regulation MAPK9 TNF 24502696 1233130 Positive_regulation MAPK9 TNF 24502696 1233131 Positive_regulation MAPK9 TNF 24502696 1233176 Positive_regulation MAPK9 TNF 24502696 1233177 Positive_regulation MAPK9 TNF 24502696 1233228 Positive_regulation MAPK9 TNF 24502696 1233280 Positive_regulation MAPK9 TNF 24502696 1233302 Positive_regulation MAPK9 TNF 24587316 2929420 Positive_regulation MAPK9 TNF 24614867 2933191 Positive_regulation MAPK9 TNF 24616552 1757566 Positive_regulation MAPK9 TNF 24707477 188363 Positive_regulation MAPK9 TNF 24707477 188443 Positive_regulation MAPK9 TNF 24707477 188473 Positive_regulation MAPK9 TNF 24758719 1483157 Positive_regulation MAPK9 TNF 24773466 34213 Positive_regulation MAPK9 TNF 24821138 2969106 Positive_regulation MAPK9 TNF 24886088 347476 Positive_regulation MAPK9 TNF 25090227 2995091 Positive_regulation MAPK9 TNF 25110549 2229796 Positive_regulation MAPK9 TNF 25114952 3156822 Positive_regulation MAPK9 TNF 25114952 3156838 Positive_regulation MAPK9 TNF 25152756 826709 Positive_regulation MAPK9 TNF 25196285 3224120 Positive_regulation MAPK9 TNF 25206704 2005733 Positive_regulation MAPK9 TNF 25435878 1074940 Positive_regulation MAPK9 TNF 7525608 1436385 Positive_regulation MAPK9 TNF 7530764 1590006 Positive_regulation MAPK9 TNF 8562342 445255 Positive_regulation MAPK9 TNF 8666946 1597676 Positive_regulation MAPK9 TNFSF10 21654829 552329 Positive_regulation MAPK9 TNFSF10 22462553 1230468 Positive_regulation MAPK9 TNFSF10 22719861 2653334 Positive_regulation MAPKAP1 FOXO1 23875175 945955 Positive_regulation MAPKAP1 TLR7 24740015 2953996 Positive_regulation MAPKAPK2 EPHB2 23275061 1148210 Positive_regulation MAPKAPK2 EPHB2 9679149 1468963 Positive_regulation MAPKAPK2 NES 19296855 400573 Positive_regulation MAPKAPK2 TLR7 23901045 1065465 Positive_regulation MAPKAPK2 TLR7 23901045 1065523 Positive_regulation MAPKAPK2 TNF 19343194 2290492 Positive_regulation MAPKAPK3 MAP2K6 23803734 543690 Positive_regulation MAPKAPK5 FOXO1 23878308 1572877 Positive_regulation MAPKAPK5 NES 20734105 599317 Positive_regulation MAPRE1 NES 15251038 277804 Positive_regulation MAPRE3 EPHB2 19182796 1965178 Positive_regulation MAPT AXIN2 22647208 406169 Positive_regulation MARC1 TNF 23148668 3215181 Positive_regulation MARCKSL1 FHL1 15113405 231120 Positive_regulation MARCKSL1 TNF 20433712 328931 Positive_regulation MARCO TLR7 25089703 2994605 Positive_regulation MARK1 DAPK1 24853415 575977 Positive_regulation MARK1 DAPK1 24860424 931893 Positive_regulation MARK1 F2R 21318117 2234219 Positive_regulation MARK2 DAPK1 24853415 575976 Positive_regulation MARK2 DAPK1 24860424 931890 Positive_regulation MARK3 DAPK1 24860424 931896 Positive_regulation MARK4 DAPK1 24860424 931887 Positive_regulation MARVELD1 RNASE1 23826386 2812446 Positive_regulation MAT2B TNF 24212770 498147 Positive_regulation MATK CCND1 23800081 1481052 Positive_regulation MATK EPHB2 21298035 2499472 Positive_regulation MATK EPHB2 21772273 1933183 Positive_regulation MATN2 BMP7 24895400 1487949 Positive_regulation MATN2 NFIX 24895400 1487893 Positive_regulation MATN2 NFIX 24895400 1487894 Positive_regulation MATN2 TULP3 23448136 245402 Positive_regulation MATR3 MMP7 21771347 3119760 Positive_regulation MAVS TLR7 16785313 1540796 Positive_regulation MB PGC 23687941 1653616 Positive_regulation MBD1 CLU 15917437 2016594 Positive_regulation MBD2 CLU 15917437 2016595 Positive_regulation MBD3 CLU 15917437 2016596 Positive_regulation MBD4 CLU 15917437 2016597 Positive_regulation MBD5 CLU 15917437 2016592 Positive_regulation MBD6 CLU 15917437 2016593 Positive_regulation MBL2 TNF 24391778 2904467 Positive_regulation MBOAT1 CD14 17997851 1625040 Positive_regulation MBP EPHB2 16261195 2288441 Positive_regulation MBP EPHB2 23658734 2790000 Positive_regulation MBP S100B 25536222 3035764 Positive_regulation MBP STK39 20532220 3047319 Positive_regulation MBS1 KRT38 16365160 1326104 Positive_regulation MBS1 RNASE1 19528073 2046542 Positive_regulation MBS1 RNASE7 19528073 2046550 Positive_regulation MBS1 TNF 24498365 2919259 Positive_regulation MBTPS1 EPHB2 17449940 1634823 Positive_regulation MBTPS1 EPHB2 19077254 385110 Positive_regulation MBTPS1 EPHB2 21686182 1091045 Positive_regulation MBTPS1 EPHB2 23320105 2739641 Positive_regulation MBTPS1 EPHB2 23706742 517224 Positive_regulation MBTPS1 EPHB2 24798342 2189746 Positive_regulation MBTPS1 F2R 22482044 661513 Positive_regulation MBTPS1 MMP28 25245676 2201762 Positive_regulation MBTPS1 MMP7 25245676 2201778 Positive_regulation MBTPS1 S1PR3 15583019 1533991 Positive_regulation MBTPS1 S1PR3 16636149 1329282 Positive_regulation MBTPS1 S1PR3 21687504 950268 Positive_regulation MBTPS1 S1PR3 21687504 950270 Positive_regulation MBTPS1 S1PR3 22802910 2219373 Positive_regulation MBTPS1 S1PR3 22802910 2219374 Positive_regulation MBTPS1 S1PR3 24970177 208701 Positive_regulation MBTPS1 S1PR3 25010828 2988058 Positive_regulation MBTPS1 S1PR3 25245676 2201763 Positive_regulation MBTPS1 SPHK1 20498849 2451127 Positive_regulation MBTPS1 SPHK1 20577214 1985420 Positive_regulation MBTPS1 SPHK1 20634980 2455695 Positive_regulation MBTPS1 SPHK1 20634980 2455783 Positive_regulation MBTPS1 SPHK1 21304987 2502011 Positive_regulation MBTPS1 SPHK1 21304987 2502052 Positive_regulation MBTPS1 SPHK1 21304987 2502062 Positive_regulation MBTPS1 SPHK1 22615770 2643591 Positive_regulation MBTPS1 SPHK1 24349009 2896554 Positive_regulation MBTPS1 SPHK1 24626169 840449 Positive_regulation MBTPS1 SPHK1 24959278 2168981 Positive_regulation MBTPS1 SPHK1 24970177 208686 Positive_regulation MBTPS1 SPHK1 25109605 2171865 Positive_regulation MBTPS1 SPHK1 25153718 2198619 Positive_regulation MBTPS1 SPHK1 25309325 871452 Positive_regulation MBTPS1 SPHK1 25309325 871459 Positive_regulation MBTPS1 TNF 21668976 305694 Positive_regulation MBTPS1 TNF 22257771 3160816 Positive_regulation MBTPS1 TNF 24058758 1704961 Positive_regulation MBTPS1 TNF 24058758 1704969 Positive_regulation MBTPS1 TNF 24586752 2926294 Positive_regulation MBTPS1 TNF 24586752 2926295 Positive_regulation MC1R MAP2K6 21071418 2058042 Positive_regulation MCAM F2R 24281035 501236 Positive_regulation MCL1 EPHB2 21258408 2137623 Positive_regulation MCL1 EPHB2 21258408 2137639 Positive_regulation MCL1 EPHB2 22253918 2588363 Positive_regulation MCL1 EPHB2 22403613 2609016 Positive_regulation MCL1 EPHB2 22649777 939978 Positive_regulation MCL1 EPHB2 22751450 1720730 Positive_regulation MCL1 EPHB2 23056582 2702354 Positive_regulation MCL1 EPHB2 23088735 1698923 Positive_regulation MCL1 EPHB2 23158473 1867281 Positive_regulation MCL1 EPHB2 23524590 218366 Positive_regulation MCL1 EPHB2 23773282 483496 Positive_regulation MCL1 EPHB2 24779770 1874249 Positive_regulation MCL1 EPHB2 24779770 1874251 Positive_regulation MCL1 EPHB2 25621172 493608 Positive_regulation MCL1 MAP2K6 18769617 2396016 Positive_regulation MCL1 MAP2K6 21258408 2137646 Positive_regulation MCL1 MAP2K6 22761917 2659238 Positive_regulation MCL1 MAP2K6 23088735 1698929 Positive_regulation MCL1 MAP2K6 23455493 2182393 Positive_regulation MCL1 MAP2K6 23524590 218372 Positive_regulation MCL1 MAP2K6 24263101 569186 Positive_regulation MCL1 MAP2K6 24594907 2930085 Positive_regulation MCL1 MMP28 21304825 2499979 Positive_regulation MCL1 MMP7 21304825 2499994 Positive_regulation MCL1 TNF 19405951 113150 Positive_regulation MCL1 TNFSF10 24529193 271594 Positive_regulation MCL1 TNFSF10 24529193 271605 Positive_regulation MCL1 TNFSF10 24566141 1124103 Positive_regulation MCL1 TNFSF10 24566141 1124104 Positive_regulation MCL1 TNFSF10 24566141 1124105 Positive_regulation MCL1 TNFSF10 24566141 1124106 Positive_regulation MCL1 TNFSF10 24566141 1124131 Positive_regulation MCS TLR7 22707950 901724 Positive_regulation MCS TNF 17242164 1544185 Positive_regulation MCS TNF 17242164 1544194 Positive_regulation MCS TNF 21980488 2560957 Positive_regulation MCTS1 CCND1 23211466 2181779 Positive_regulation MDK MAP2K6 23976985 2837991 Positive_regulation MDM1 TLR7 21904615 2550433 Positive_regulation MDM1 TNF 24070317 3210719 Positive_regulation MDM2 EPHB2 20860815 1859271 Positive_regulation MDM2 EPHB2 25431954 2207416 Positive_regulation MDM2 HBEGF 23236372 2725997 Positive_regulation MDM2 HBEGF 23236372 2726019 Positive_regulation MDM2 HBEGF 23236372 2726024 Positive_regulation MDM2 TLR7 21904615 2550443 Positive_regulation MDM2 TNF 24070317 3210723 Positive_regulation MDM4 TLR7 21904615 2550453 Positive_regulation MDM4 TNF 24070317 3210726 Positive_regulation MECP2 FOXO1 25329053 2365596 Positive_regulation MED1 ALOX5 23991239 2372056 Positive_regulation MED1 ARSA 15824083 1535501 Positive_regulation MED1 CLU 23164821 1901073 Positive_regulation MED1 EDN2 9792333 1763744 Positive_regulation MED1 EPHB2 12769834 369156 Positive_regulation MED1 EPHB2 21559295 2518100 Positive_regulation MED1 EPHB2 21559295 2518117 Positive_regulation MED1 EPHB2 22216095 2584390 Positive_regulation MED1 EPHB2 22319481 860867 Positive_regulation MED1 EPHB2 22817771 472009 Positive_regulation MED1 EPHB2 24045785 3137128 Positive_regulation MED1 EPHB2 24045785 3137193 Positive_regulation MED1 EPHB2 24045785 3137194 Positive_regulation MED1 EPHB2 24358311 2899526 Positive_regulation MED1 EPHB2 25068892 622528 Positive_regulation MED1 EPHB2 25068892 622529 Positive_regulation MED1 EPHB2 25068892 622532 Positive_regulation MED1 IL1B 11132773 1737349 Positive_regulation MED1 RCAN1 19124655 1553432 Positive_regulation MED1 TLR7 15804356 3104583 Positive_regulation MED1 TLR7 18584038 3073146 Positive_regulation MED1 TLR7 18584038 3073887 Positive_regulation MED1 TLR7 18815618 631785 Positive_regulation MED1 TLR7 20871832 1748286 Positive_regulation MED1 TLR7 22691272 126318 Positive_regulation MED1 TLR7 22785227 1919321 Positive_regulation MED1 TNF 10408703 414852 Positive_regulation MED1 TNF 11132773 1737348 Positive_regulation MED1 TNF 18410682 110450 Positive_regulation MED1 TNF 18410682 110492 Positive_regulation MED1 TNF 19712471 1625703 Positive_regulation MED1 TNF 21904602 2550391 Positive_regulation MED1 TNF 22566867 899054 Positive_regulation MED1 TNF 22691272 126317 Positive_regulation MED1 TNF 22723832 2654736 Positive_regulation MED1 TNF 22723832 2654768 Positive_regulation MED1 TNF 23824685 2809210 Positive_regulation MED1 TNF 24300561 2247630 Positive_regulation MED1 TNF 24971461 2984579 Positive_regulation MED1 TNF 25275456 2373050 Positive_regulation MED1 TNF 3435705 443430 Positive_regulation MED1 TNF 7540649 1590350 Positive_regulation MED10 ALOX5 23991239 2372051 Positive_regulation MED10 CLU 23164821 1901062 Positive_regulation MED10 EDN2 9792333 1763732 Positive_regulation MED10 EPHB2 12769834 369148 Positive_regulation MED10 EPHB2 22216095 2584386 Positive_regulation MED10 EPHB2 22817771 471992 Positive_regulation MED10 IL1B 11132773 1737339 Positive_regulation MED10 RCAN1 19124655 1553428 Positive_regulation MED10 TLR7 15804356 3104528 Positive_regulation MED10 TLR7 18584038 3073095 Positive_regulation MED10 TLR7 18584038 3073847 Positive_regulation MED10 TLR7 18815618 631745 Positive_regulation MED10 TLR7 20871832 1748246 Positive_regulation MED10 TLR7 22691272 126303 Positive_regulation MED10 TLR7 22785227 1919267 Positive_regulation MED10 TNF 10408703 414847 Positive_regulation MED10 TNF 11132773 1737338 Positive_regulation MED10 TNF 18410682 110432 Positive_regulation MED10 TNF 18410682 110487 Positive_regulation MED10 TNF 19712471 1625685 Positive_regulation MED10 TNF 21904602 2550386 Positive_regulation MED10 TNF 22566867 899050 Positive_regulation MED10 TNF 22691272 126302 Positive_regulation MED10 TNF 22723832 2654731 Positive_regulation MED10 TNF 22723832 2654762 Positive_regulation MED10 TNF 23824685 2809206 Positive_regulation MED10 TNF 24300561 2247625 Positive_regulation MED10 TNF 24971461 2984499 Positive_regulation MED10 TNF 25275456 2373046 Positive_regulation MED10 TNF 3435705 443426 Positive_regulation MED10 TNF 7540649 1590345 Positive_regulation MED11 ALOX5 23991239 2372054 Positive_regulation MED11 CLU 23164821 1901069 Positive_regulation MED11 EDN2 9792333 1763741 Positive_regulation MED11 EPHB2 12769834 369151 Positive_regulation MED11 EPHB2 22216095 2584389 Positive_regulation MED11 EPHB2 22817771 472004 Positive_regulation MED11 IL1B 11132773 1737345 Positive_regulation MED11 RCAN1 19124655 1553431 Positive_regulation MED11 TLR7 15804356 3104561 Positive_regulation MED11 TLR7 18584038 3073125 Positive_regulation MED11 TLR7 18584038 3073877 Positive_regulation MED11 TLR7 18815618 631775 Positive_regulation MED11 TLR7 20871832 1748276 Positive_regulation MED11 TLR7 22691272 126312 Positive_regulation MED11 TLR7 22785227 1919310 Positive_regulation MED11 TNF 10408703 414850 Positive_regulation MED11 TNF 11132773 1737344 Positive_regulation MED11 TNF 18410682 110435 Positive_regulation MED11 TNF 18410682 110490 Positive_regulation MED11 TNF 21904602 2550389 Positive_regulation MED11 TNF 22566867 899053 Positive_regulation MED11 TNF 22691272 126311 Positive_regulation MED11 TNF 22723832 2654734 Positive_regulation MED11 TNF 22723832 2654765 Positive_regulation MED11 TNF 23824685 2809209 Positive_regulation MED11 TNF 24300561 2247628 Positive_regulation MED11 TNF 24971461 2984508 Positive_regulation MED11 TNF 25275456 2373049 Positive_regulation MED11 TNF 3435705 443429 Positive_regulation MED11 TNF 7540649 1590348 Positive_regulation MED12 ARSA 15824083 1535488 Positive_regulation MED12 EDN2 9792333 1763657 Positive_regulation MED12 EPHB2 12769834 369120 Positive_regulation MED12 EPHB2 21559295 2518083 Positive_regulation MED12 EPHB2 21559295 2518101 Positive_regulation MED12 EPHB2 22216095 2584361 Positive_regulation MED12 EPHB2 22319481 860841 Positive_regulation MED12 EPHB2 22817771 471892 Positive_regulation MED12 EPHB2 24045785 3137112 Positive_regulation MED12 EPHB2 24045785 3137166 Positive_regulation MED12 EPHB2 24045785 3137167 Positive_regulation MED12 RCAN1 19124655 1553403 Positive_regulation MED12 TLR7 18584038 3072845 Positive_regulation MED12 TLR7 18584038 3073597 Positive_regulation MED12 TLR7 18815618 631335 Positive_regulation MED12 TLR7 20871832 1747996 Positive_regulation MED12 TLR7 22785227 1918987 Positive_regulation MED12 TNF 19712471 1625661 Positive_regulation MED12 TNF 22566867 899025 Positive_regulation MED12 TNF 23824685 2809181 Positive_regulation MED12 TNF 24300561 2247600 Positive_regulation MED12 TNF 24971461 2984424 Positive_regulation MED12 TNF 25275456 2373021 Positive_regulation MED12 TNF 3435705 443401 Positive_regulation MED12 TNF 7540649 1590320 Positive_regulation MED13 ALOX5 23991239 2372038 Positive_regulation MED13 ARSA 15824083 1535493 Positive_regulation MED13 CLU 23164821 1901036 Positive_regulation MED13 EDN2 9792333 1763687 Positive_regulation MED13 EPHB2 12769834 369131 Positive_regulation MED13 EPHB2 21559295 2518088 Positive_regulation MED13 EPHB2 21559295 2518106 Positive_regulation MED13 EPHB2 22216095 2584371 Positive_regulation MED13 EPHB2 22319481 860851 Positive_regulation MED13 EPHB2 22817771 471932 Positive_regulation MED13 EPHB2 24045785 3137117 Positive_regulation MED13 EPHB2 24045785 3137176 Positive_regulation MED13 EPHB2 24045785 3137177 Positive_regulation MED13 IL1B 11132773 1737313 Positive_regulation MED13 RCAN1 19124655 1553413 Positive_regulation MED13 TLR7 15804356 3104385 Positive_regulation MED13 TLR7 18584038 3072945 Positive_regulation MED13 TLR7 18584038 3073697 Positive_regulation MED13 TLR7 18815618 631595 Positive_regulation MED13 TLR7 20871832 1748096 Positive_regulation MED13 TLR7 22691272 126264 Positive_regulation MED13 TLR7 22785227 1919102 Positive_regulation MED13 TNF 10408703 414834 Positive_regulation MED13 TNF 11132773 1737312 Positive_regulation MED13 TNF 18410682 110418 Positive_regulation MED13 TNF 18410682 110474 Positive_regulation MED13 TNF 19712471 1625671 Positive_regulation MED13 TNF 21904602 2550373 Positive_regulation MED13 TNF 22566867 899035 Positive_regulation MED13 TNF 22691272 126263 Positive_regulation MED13 TNF 22723832 2654718 Positive_regulation MED13 TNF 22723832 2654749 Positive_regulation MED13 TNF 23824685 2809191 Positive_regulation MED13 TNF 24300561 2247610 Positive_regulation MED13 TNF 24971461 2984454 Positive_regulation MED13 TNF 25275456 2373031 Positive_regulation MED13 TNF 3435705 443411 Positive_regulation MED13 TNF 7540649 1590330 Positive_regulation MED13L ALOX5 23991239 2372039 Positive_regulation MED13L CLU 23164821 1901038 Positive_regulation MED13L EDN2 9792333 1763690 Positive_regulation MED13L EPHB2 12769834 369132 Positive_regulation MED13L EPHB2 22216095 2584372 Positive_regulation MED13L EPHB2 22817771 471936 Positive_regulation MED13L IL1B 11132773 1737315 Positive_regulation MED13L RCAN1 19124655 1553414 Positive_regulation MED13L TLR7 15804356 3104396 Positive_regulation MED13L TLR7 18584038 3072955 Positive_regulation MED13L TLR7 18584038 3073707 Positive_regulation MED13L TLR7 18815618 631605 Positive_regulation MED13L TLR7 20871832 1748106 Positive_regulation MED13L TLR7 22691272 126267 Positive_regulation MED13L TLR7 22785227 1919113 Positive_regulation MED13L TNF 10408703 414835 Positive_regulation MED13L TNF 11132773 1737314 Positive_regulation MED13L TNF 18410682 110419 Positive_regulation MED13L TNF 18410682 110475 Positive_regulation MED13L TNF 21904602 2550374 Positive_regulation MED13L TNF 22566867 899036 Positive_regulation MED13L TNF 22691272 126266 Positive_regulation MED13L TNF 22723832 2654719 Positive_regulation MED13L TNF 22723832 2654750 Positive_regulation MED13L TNF 23824685 2809192 Positive_regulation MED13L TNF 24300561 2247611 Positive_regulation MED13L TNF 24971461 2984457 Positive_regulation MED13L TNF 25275456 2373032 Positive_regulation MED13L TNF 3435705 443412 Positive_regulation MED13L TNF 7540649 1590331 Positive_regulation MED14 ALOX5 23991239 2372043 Positive_regulation MED14 ARSA 15824083 1535495 Positive_regulation MED14 CLU 23164821 1901046 Positive_regulation MED14 EDN2 9792333 1763702 Positive_regulation MED14 EPHB2 12769834 369138 Positive_regulation MED14 EPHB2 21559295 2518090 Positive_regulation MED14 EPHB2 21559295 2518108 Positive_regulation MED14 EPHB2 22216095 2584376 Positive_regulation MED14 EPHB2 22319481 860855 Positive_regulation MED14 EPHB2 22817771 471952 Positive_regulation MED14 EPHB2 24045785 3137119 Positive_regulation MED14 EPHB2 24045785 3137180 Positive_regulation MED14 EPHB2 24045785 3137181 Positive_regulation MED14 EPHB2 24049075 2093736 Positive_regulation MED14 IL1B 11132773 1737323 Positive_regulation MED14 RCAN1 19124655 1553418 Positive_regulation MED14 TLR7 15804356 3104440 Positive_regulation MED14 TLR7 18584038 3072995 Positive_regulation MED14 TLR7 18584038 3073747 Positive_regulation MED14 TLR7 18815618 631645 Positive_regulation MED14 TLR7 20871832 1748146 Positive_regulation MED14 TLR7 22691272 126279 Positive_regulation MED14 TLR7 22785227 1919157 Positive_regulation MED14 TNF 10408703 414839 Positive_regulation MED14 TNF 11132773 1737322 Positive_regulation MED14 TNF 18410682 110423 Positive_regulation MED14 TNF 18410682 110479 Positive_regulation MED14 TNF 19712471 1625677 Positive_regulation MED14 TNF 21904602 2550378 Positive_regulation MED14 TNF 22566867 899040 Positive_regulation MED14 TNF 22691272 126278 Positive_regulation MED14 TNF 22723832 2654723 Positive_regulation MED14 TNF 22723832 2654754 Positive_regulation MED14 TNF 23824685 2809196 Positive_regulation MED14 TNF 24300561 2247615 Positive_regulation MED14 TNF 24971461 2984469 Positive_regulation MED14 TNF 25275456 2373036 Positive_regulation MED14 TNF 3435705 443416 Positive_regulation MED14 TNF 7540649 1590335 Positive_regulation MED15 ALOX5 23991239 2372032 Positive_regulation MED15 CLU 23164821 1901024 Positive_regulation MED15 EDN2 9792333 1763660 Positive_regulation MED15 EPHB2 12769834 369121 Positive_regulation MED15 EPHB2 21559295 2518084 Positive_regulation MED15 EPHB2 21559295 2518102 Positive_regulation MED15 EPHB2 22216095 2584362 Positive_regulation MED15 EPHB2 22319481 860843 Positive_regulation MED15 EPHB2 22817771 471896 Positive_regulation MED15 EPHB2 24045785 3137113 Positive_regulation MED15 EPHB2 24045785 3137168 Positive_regulation MED15 EPHB2 24045785 3137169 Positive_regulation MED15 IL1B 11132773 1737301 Positive_regulation MED15 RCAN1 19124655 1553404 Positive_regulation MED15 TLR7 15804356 3104319 Positive_regulation MED15 TLR7 18584038 3072855 Positive_regulation MED15 TLR7 18584038 3073607 Positive_regulation MED15 TLR7 18815618 631345 Positive_regulation MED15 TLR7 20871832 1748006 Positive_regulation MED15 TLR7 22691272 126190 Positive_regulation MED15 TLR7 22785227 1918998 Positive_regulation MED15 TNF 10408703 414828 Positive_regulation MED15 TNF 11132773 1737300 Positive_regulation MED15 TNF 18410682 110412 Positive_regulation MED15 TNF 18410682 110468 Positive_regulation MED15 TNF 21904602 2550366 Positive_regulation MED15 TNF 22566867 899026 Positive_regulation MED15 TNF 22691272 126189 Positive_regulation MED15 TNF 22723832 2654712 Positive_regulation MED15 TNF 22723832 2654742 Positive_regulation MED15 TNF 23824685 2809182 Positive_regulation MED15 TNF 24300561 2247601 Positive_regulation MED15 TNF 24971461 2984427 Positive_regulation MED15 TNF 25275456 2373022 Positive_regulation MED15 TNF 3435705 443402 Positive_regulation MED15 TNF 7540649 1590321 Positive_regulation MED16 ALOX5 23991239 2372034 Positive_regulation MED16 ARSA 15824083 1535490 Positive_regulation MED16 CLU 23164821 1901028 Positive_regulation MED16 EDN2 9792333 1763669 Positive_regulation MED16 EPHB2 12769834 369125 Positive_regulation MED16 EPHB2 22216095 2584365 Positive_regulation MED16 EPHB2 22817771 471908 Positive_regulation MED16 IL1B 11132773 1737305 Positive_regulation MED16 RCAN1 19124655 1553407 Positive_regulation MED16 TLR7 15804356 3104341 Positive_regulation MED16 TLR7 18584038 3072885 Positive_regulation MED16 TLR7 18584038 3073637 Positive_regulation MED16 TLR7 18815618 631535 Positive_regulation MED16 TLR7 20871832 1748036 Positive_regulation MED16 TLR7 22691272 126252 Positive_regulation MED16 TLR7 22785227 1919036 Positive_regulation MED16 TNF 10408703 414830 Positive_regulation MED16 TNF 11132773 1737304 Positive_regulation MED16 TNF 18410682 110414 Positive_regulation MED16 TNF 18410682 110470 Positive_regulation MED16 TNF 19712471 1625665 Positive_regulation MED16 TNF 21904602 2550369 Positive_regulation MED16 TNF 22566867 899029 Positive_regulation MED16 TNF 22691272 126251 Positive_regulation MED16 TNF 22723832 2654714 Positive_regulation MED16 TNF 22723832 2654745 Positive_regulation MED16 TNF 23824685 2809185 Positive_regulation MED16 TNF 24300561 2247604 Positive_regulation MED16 TNF 24971461 2984436 Positive_regulation MED16 TNF 25275456 2373025 Positive_regulation MED16 TNF 3435705 443405 Positive_regulation MED16 TNF 7540649 1590324 Positive_regulation MED17 ALOX5 23991239 2372045 Positive_regulation MED17 ARSA 15824083 1535497 Positive_regulation MED17 CLU 23164821 1901050 Positive_regulation MED17 EDN2 9792333 1763708 Positive_regulation MED17 EPHB2 12769834 369140 Positive_regulation MED17 EPHB2 21559295 2518092 Positive_regulation MED17 EPHB2 21559295 2518110 Positive_regulation MED17 EPHB2 22216095 2584378 Positive_regulation MED17 EPHB2 22319481 860859 Positive_regulation MED17 EPHB2 22817771 471960 Positive_regulation MED17 EPHB2 24045785 3137121 Positive_regulation MED17 EPHB2 24045785 3137184 Positive_regulation MED17 EPHB2 24045785 3137185 Positive_regulation MED17 IL1B 11132773 1737327 Positive_regulation MED17 RCAN1 19124655 1553420 Positive_regulation MED17 TLR7 15804356 3104462 Positive_regulation MED17 TLR7 18584038 3073015 Positive_regulation MED17 TLR7 18584038 3073767 Positive_regulation MED17 TLR7 18815618 631665 Positive_regulation MED17 TLR7 20871832 1748166 Positive_regulation MED17 TLR7 22691272 126285 Positive_regulation MED17 TLR7 22785227 1919179 Positive_regulation MED17 TNF 10408703 414841 Positive_regulation MED17 TNF 11132773 1737326 Positive_regulation MED17 TNF 18410682 110425 Positive_regulation MED17 TNF 18410682 110481 Positive_regulation MED17 TNF 19712471 1625679 Positive_regulation MED17 TNF 21904602 2550380 Positive_regulation MED17 TNF 22566867 899042 Positive_regulation MED17 TNF 22691272 126284 Positive_regulation MED17 TNF 22723832 2654725 Positive_regulation MED17 TNF 22723832 2654756 Positive_regulation MED17 TNF 23824685 2809198 Positive_regulation MED17 TNF 24300561 2247617 Positive_regulation MED17 TNF 24971461 2984475 Positive_regulation MED17 TNF 25275456 2373038 Positive_regulation MED17 TNF 3435705 443418 Positive_regulation MED17 TNF 7540649 1590337 Positive_regulation MED18 ALOX5 23991239 2372050 Positive_regulation MED18 CLU 23164821 1901060 Positive_regulation MED18 EDN2 9792333 1763729 Positive_regulation MED18 EPHB2 12769834 369147 Positive_regulation MED18 EPHB2 22216095 2584385 Positive_regulation MED18 EPHB2 22817771 471988 Positive_regulation MED18 IL1B 11132773 1737337 Positive_regulation MED18 RCAN1 19124655 1553427 Positive_regulation MED18 TLR7 15804356 3104517 Positive_regulation MED18 TLR7 18584038 3073085 Positive_regulation MED18 TLR7 18584038 3073837 Positive_regulation MED18 TLR7 18815618 631735 Positive_regulation MED18 TLR7 20871832 1748236 Positive_regulation MED18 TLR7 22691272 126300 Positive_regulation MED18 TLR7 22785227 1919256 Positive_regulation MED18 TNF 10408703 414846 Positive_regulation MED18 TNF 11132773 1737336 Positive_regulation MED18 TNF 18410682 110431 Positive_regulation MED18 TNF 18410682 110486 Positive_regulation MED18 TNF 21904602 2550385 Positive_regulation MED18 TNF 22566867 899049 Positive_regulation MED18 TNF 22691272 126299 Positive_regulation MED18 TNF 22723832 2654730 Positive_regulation MED18 TNF 22723832 2654761 Positive_regulation MED18 TNF 23824685 2809205 Positive_regulation MED18 TNF 24300561 2247624 Positive_regulation MED18 TNF 24971461 2984496 Positive_regulation MED18 TNF 25275456 2373045 Positive_regulation MED18 TNF 3435705 443425 Positive_regulation MED18 TNF 7540649 1590344 Positive_regulation MED19 ALOX5 23991239 2372053 Positive_regulation MED19 CLU 23164821 1901067 Positive_regulation MED19 EDN2 9792333 1763738 Positive_regulation MED19 EPHB2 12769834 369150 Positive_regulation MED19 EPHB2 22216095 2584388 Positive_regulation MED19 EPHB2 22817771 472000 Positive_regulation MED19 IL1B 11132773 1737343 Positive_regulation MED19 RCAN1 19124655 1553430 Positive_regulation MED19 TLR7 15804356 3104550 Positive_regulation MED19 TLR7 18584038 3073115 Positive_regulation MED19 TLR7 18584038 3073867 Positive_regulation MED19 TLR7 18815618 631765 Positive_regulation MED19 TLR7 20871832 1748266 Positive_regulation MED19 TLR7 22691272 126309 Positive_regulation MED19 TLR7 22785227 1919289 Positive_regulation MED19 TNF 10408703 414849 Positive_regulation MED19 TNF 11132773 1737342 Positive_regulation MED19 TNF 18410682 110434 Positive_regulation MED19 TNF 18410682 110489 Positive_regulation MED19 TNF 21904602 2550388 Positive_regulation MED19 TNF 22566867 899052 Positive_regulation MED19 TNF 22691272 126308 Positive_regulation MED19 TNF 22723832 2654733 Positive_regulation MED19 TNF 22723832 2654764 Positive_regulation MED19 TNF 23824685 2809208 Positive_regulation MED19 TNF 24300561 2247627 Positive_regulation MED19 TNF 24971461 2984505 Positive_regulation MED19 TNF 25275456 2373048 Positive_regulation MED19 TNF 3435705 443428 Positive_regulation MED19 TNF 7540649 1590347 Positive_regulation MED20 ALOX5 23991239 2372033 Positive_regulation MED20 CLU 23164821 1901026 Positive_regulation MED20 EDN2 9792333 1763666 Positive_regulation MED20 EPHB2 12769834 369123 Positive_regulation MED20 EPHB2 22216095 2584364 Positive_regulation MED20 EPHB2 22817771 471904 Positive_regulation MED20 IL1B 11132773 1737303 Positive_regulation MED20 RCAN1 19124655 1553406 Positive_regulation MED20 TLR7 15804356 3104330 Positive_regulation MED20 TLR7 18584038 3072875 Positive_regulation MED20 TLR7 18584038 3073627 Positive_regulation MED20 TLR7 18815618 631525 Positive_regulation MED20 TLR7 20871832 1748026 Positive_regulation MED20 TLR7 22691272 126249 Positive_regulation MED20 TLR7 22785227 1919025 Positive_regulation MED20 TNF 10408703 414829 Positive_regulation MED20 TNF 11132773 1737302 Positive_regulation MED20 TNF 18410682 110413 Positive_regulation MED20 TNF 18410682 110469 Positive_regulation MED20 TNF 21904602 2550368 Positive_regulation MED20 TNF 22566867 899028 Positive_regulation MED20 TNF 22691272 126248 Positive_regulation MED20 TNF 22723832 2654713 Positive_regulation MED20 TNF 22723832 2654744 Positive_regulation MED20 TNF 23824685 2809184 Positive_regulation MED20 TNF 24300561 2247603 Positive_regulation MED20 TNF 24971461 2984433 Positive_regulation MED20 TNF 25275456 2373024 Positive_regulation MED20 TNF 3435705 443404 Positive_regulation MED20 TNF 7540649 1590323 Positive_regulation MED21 ALOX5 23991239 2372030 Positive_regulation MED21 CLU 23164821 1901019 Positive_regulation MED21 EDN2 9792333 1763651 Positive_regulation MED21 EPHB2 12769834 369118 Positive_regulation MED21 EPHB2 22216095 2584359 Positive_regulation MED21 EPHB2 22319481 860839 Positive_regulation MED21 EPHB2 22817771 471884 Positive_regulation MED21 EPHB2 24045785 3137165 Positive_regulation MED21 IL1B 11132773 1737297 Positive_regulation MED21 RCAN1 19124655 1553401 Positive_regulation MED21 TLR7 15804356 3104297 Positive_regulation MED21 TLR7 18584038 3072825 Positive_regulation MED21 TLR7 18584038 3073577 Positive_regulation MED21 TLR7 18815618 631155 Positive_regulation MED21 TLR7 20871832 1747976 Positive_regulation MED21 TLR7 22691272 126155 Positive_regulation MED21 TLR7 22785227 1918960 Positive_regulation MED21 TNF 10408703 414826 Positive_regulation MED21 TNF 11132773 1737296 Positive_regulation MED21 TNF 18410682 110368 Positive_regulation MED21 TNF 18410682 110466 Positive_regulation MED21 TNF 19712471 1625641 Positive_regulation MED21 TNF 21904602 2550361 Positive_regulation MED21 TNF 22566867 899023 Positive_regulation MED21 TNF 22691272 126154 Positive_regulation MED21 TNF 22723832 2654710 Positive_regulation MED21 TNF 22723832 2654739 Positive_regulation MED21 TNF 23824685 2809179 Positive_regulation MED21 TNF 24300561 2247598 Positive_regulation MED21 TNF 24971461 2984383 Positive_regulation MED21 TNF 25275456 2373019 Positive_regulation MED21 TNF 3435705 443397 Positive_regulation MED21 TNF 7540649 1590286 Positive_regulation MED22 ALOX5 23991239 2372031 Positive_regulation MED22 CLU 23164821 1901021 Positive_regulation MED22 EDN2 9792333 1763654 Positive_regulation MED22 EPHB2 12769834 369119 Positive_regulation MED22 EPHB2 22216095 2584360 Positive_regulation MED22 EPHB2 22817771 471888 Positive_regulation MED22 IL1B 11132773 1737299 Positive_regulation MED22 RCAN1 19124655 1553402 Positive_regulation MED22 TLR7 15804356 3104308 Positive_regulation MED22 TLR7 18584038 3072835 Positive_regulation MED22 TLR7 18584038 3073587 Positive_regulation MED22 TLR7 18815618 631165 Positive_regulation MED22 TLR7 20871832 1747986 Positive_regulation MED22 TLR7 22691272 126158 Positive_regulation MED22 TLR7 22785227 1918971 Positive_regulation MED22 TNF 10408703 414827 Positive_regulation MED22 TNF 11132773 1737298 Positive_regulation MED22 TNF 18410682 110369 Positive_regulation MED22 TNF 18410682 110467 Positive_regulation MED22 TNF 21904602 2550362 Positive_regulation MED22 TNF 22566867 899024 Positive_regulation MED22 TNF 22691272 126157 Positive_regulation MED22 TNF 22723832 2654711 Positive_regulation MED22 TNF 22723832 2654740 Positive_regulation MED22 TNF 23824685 2809180 Positive_regulation MED22 TNF 24300561 2247599 Positive_regulation MED22 TNF 24971461 2984386 Positive_regulation MED22 TNF 25275456 2373020 Positive_regulation MED22 TNF 3435705 443398 Positive_regulation MED22 TNF 7540649 1590287 Positive_regulation MED23 ALOX5 23991239 2372044 Positive_regulation MED23 ARSA 15824083 1535496 Positive_regulation MED23 CLU 23164821 1901048 Positive_regulation MED23 EDN2 9792333 1763705 Positive_regulation MED23 EPHB2 12769834 369139 Positive_regulation MED23 EPHB2 21559295 2518091 Positive_regulation MED23 EPHB2 21559295 2518109 Positive_regulation MED23 EPHB2 22216095 2584377 Positive_regulation MED23 EPHB2 22319481 860857 Positive_regulation MED23 EPHB2 22817771 471956 Positive_regulation MED23 EPHB2 24045785 3137120 Positive_regulation MED23 EPHB2 24045785 3137182 Positive_regulation MED23 EPHB2 24045785 3137183 Positive_regulation MED23 IL1B 11132773 1737325 Positive_regulation MED23 RCAN1 19124655 1553419 Positive_regulation MED23 TLR7 15804356 3104451 Positive_regulation MED23 TLR7 18584038 3073005 Positive_regulation MED23 TLR7 18584038 3073757 Positive_regulation MED23 TLR7 18815618 631655 Positive_regulation MED23 TLR7 20871832 1748156 Positive_regulation MED23 TLR7 22691272 126282 Positive_regulation MED23 TLR7 22785227 1919168 Positive_regulation MED23 TNF 10408703 414840 Positive_regulation MED23 TNF 11132773 1737324 Positive_regulation MED23 TNF 18410682 110424 Positive_regulation MED23 TNF 18410682 110480 Positive_regulation MED23 TNF 21904602 2550379 Positive_regulation MED23 TNF 22566867 899041 Positive_regulation MED23 TNF 22691272 126281 Positive_regulation MED23 TNF 22723832 2654724 Positive_regulation MED23 TNF 22723832 2654755 Positive_regulation MED23 TNF 23824685 2809197 Positive_regulation MED23 TNF 24300561 2247616 Positive_regulation MED23 TNF 24971461 2984472 Positive_regulation MED23 TNF 25275456 2373037 Positive_regulation MED23 TNF 3435705 443417 Positive_regulation MED23 TNF 7540649 1590336 Positive_regulation MED24 ALOX5 23991239 2372040 Positive_regulation MED24 ARSA 15824083 1535494 Positive_regulation MED24 CLU 23164821 1901040 Positive_regulation MED24 EDN2 9792333 1763693 Positive_regulation MED24 EPHB2 12769834 369133 Positive_regulation MED24 EPHB2 21559295 2518089 Positive_regulation MED24 EPHB2 21559295 2518107 Positive_regulation MED24 EPHB2 22216095 2584373 Positive_regulation MED24 EPHB2 22319481 860853 Positive_regulation MED24 EPHB2 22817771 471940 Positive_regulation MED24 EPHB2 24045785 3137118 Positive_regulation MED24 EPHB2 24045785 3137178 Positive_regulation MED24 EPHB2 24045785 3137179 Positive_regulation MED24 IL1B 11132773 1737317 Positive_regulation MED24 RCAN1 19124655 1553415 Positive_regulation MED24 TLR7 15804356 3104407 Positive_regulation MED24 TLR7 18584038 3072965 Positive_regulation MED24 TLR7 18584038 3073717 Positive_regulation MED24 TLR7 18815618 631615 Positive_regulation MED24 TLR7 20871832 1748116 Positive_regulation MED24 TLR7 22691272 126270 Positive_regulation MED24 TLR7 22785227 1919124 Positive_regulation MED24 TNF 10408703 414836 Positive_regulation MED24 TNF 11132773 1737316 Positive_regulation MED24 TNF 18410682 110420 Positive_regulation MED24 TNF 18410682 110476 Positive_regulation MED24 TNF 19712471 1625673 Positive_regulation MED24 TNF 21904602 2550375 Positive_regulation MED24 TNF 22566867 899037 Positive_regulation MED24 TNF 22691272 126269 Positive_regulation MED24 TNF 22723832 2654720 Positive_regulation MED24 TNF 22723832 2654751 Positive_regulation MED24 TNF 23824685 2809193 Positive_regulation MED24 TNF 24300561 2247612 Positive_regulation MED24 TNF 24971461 2984460 Positive_regulation MED24 TNF 25275456 2373033 Positive_regulation MED24 TNF 3435705 443413 Positive_regulation MED24 TNF 7540649 1590332 Positive_regulation MED25 ALOX5 23991239 2372052 Positive_regulation MED25 CLU 23164821 1901064 Positive_regulation MED25 EDN2 9792333 1763735 Positive_regulation MED25 EPHB2 12769834 369149 Positive_regulation MED25 EPHB2 21559295 2518095 Positive_regulation MED25 EPHB2 21559295 2518113 Positive_regulation MED25 EPHB2 22216095 2584387 Positive_regulation MED25 EPHB2 22319481 860865 Positive_regulation MED25 EPHB2 22817771 471996 Positive_regulation MED25 EPHB2 24045785 3137124 Positive_regulation MED25 EPHB2 24045785 3137190 Positive_regulation MED25 EPHB2 24045785 3137191 Positive_regulation MED25 IL1B 11132773 1737341 Positive_regulation MED25 RCAN1 19124655 1553429 Positive_regulation MED25 TLR7 15804356 3104539 Positive_regulation MED25 TLR7 18584038 3073105 Positive_regulation MED25 TLR7 18584038 3073857 Positive_regulation MED25 TLR7 18815618 631755 Positive_regulation MED25 TLR7 20871832 1748256 Positive_regulation MED25 TLR7 22691272 126306 Positive_regulation MED25 TLR7 22785227 1919278 Positive_regulation MED25 TNF 10408703 414848 Positive_regulation MED25 TNF 11132773 1737340 Positive_regulation MED25 TNF 18410682 110433 Positive_regulation MED25 TNF 18410682 110488 Positive_regulation MED25 TNF 21904602 2550387 Positive_regulation MED25 TNF 22566867 899051 Positive_regulation MED25 TNF 22691272 126305 Positive_regulation MED25 TNF 22723832 2654732 Positive_regulation MED25 TNF 22723832 2654763 Positive_regulation MED25 TNF 23824685 2809207 Positive_regulation MED25 TNF 24300561 2247626 Positive_regulation MED25 TNF 24971461 2984502 Positive_regulation MED25 TNF 25275456 2373047 Positive_regulation MED25 TNF 3435705 443427 Positive_regulation MED25 TNF 7540649 1590346 Positive_regulation MED26 ALOX5 23991239 2372046 Positive_regulation MED26 ARSA 15824083 1535498 Positive_regulation MED26 CLU 23164821 1901052 Positive_regulation MED26 EDN2 9792333 1763711 Positive_regulation MED26 EPHB2 12769834 369141 Positive_regulation MED26 EPHB2 21559295 2518093 Positive_regulation MED26 EPHB2 21559295 2518111 Positive_regulation MED26 EPHB2 22216095 2584379 Positive_regulation MED26 EPHB2 22319481 860861 Positive_regulation MED26 EPHB2 22817771 471964 Positive_regulation MED26 EPHB2 24045785 3137122 Positive_regulation MED26 EPHB2 24045785 3137186 Positive_regulation MED26 EPHB2 24045785 3137187 Positive_regulation MED26 IL1B 11132773 1737329 Positive_regulation MED26 RCAN1 19124655 1553421 Positive_regulation MED26 TLR7 15804356 3104473 Positive_regulation MED26 TLR7 18584038 3073025 Positive_regulation MED26 TLR7 18584038 3073777 Positive_regulation MED26 TLR7 18815618 631675 Positive_regulation MED26 TLR7 20871832 1748176 Positive_regulation MED26 TLR7 22691272 126288 Positive_regulation MED26 TLR7 22785227 1919190 Positive_regulation MED26 TNF 10408703 414842 Positive_regulation MED26 TNF 11132773 1737328 Positive_regulation MED26 TNF 18410682 110426 Positive_regulation MED26 TNF 18410682 110482 Positive_regulation MED26 TNF 21904602 2550381 Positive_regulation MED26 TNF 22566867 899043 Positive_regulation MED26 TNF 22691272 126287 Positive_regulation MED26 TNF 22723832 2654726 Positive_regulation MED26 TNF 22723832 2654757 Positive_regulation MED26 TNF 23824685 2809199 Positive_regulation MED26 TNF 24300561 2247618 Positive_regulation MED26 TNF 24971461 2984478 Positive_regulation MED26 TNF 25275456 2373039 Positive_regulation MED26 TNF 3435705 443419 Positive_regulation MED26 TNF 7540649 1590338 Positive_regulation MED27 ALOX5 23991239 2372047 Positive_regulation MED27 CLU 23164821 1901054 Positive_regulation MED27 EDN2 9792333 1763714 Positive_regulation MED27 EPHB2 12769834 369142 Positive_regulation MED27 EPHB2 22216095 2584380 Positive_regulation MED27 EPHB2 22817771 471968 Positive_regulation MED27 IL1B 11132773 1737331 Positive_regulation MED27 RCAN1 19124655 1553422 Positive_regulation MED27 TLR7 15804356 3104484 Positive_regulation MED27 TLR7 18584038 3073035 Positive_regulation MED27 TLR7 18584038 3073787 Positive_regulation MED27 TLR7 18815618 631685 Positive_regulation MED27 TLR7 20871832 1748186 Positive_regulation MED27 TLR7 22691272 126291 Positive_regulation MED27 TLR7 22785227 1919201 Positive_regulation MED27 TNF 10408703 414843 Positive_regulation MED27 TNF 11132773 1737330 Positive_regulation MED27 TNF 18410682 110427 Positive_regulation MED27 TNF 18410682 110483 Positive_regulation MED27 TNF 19712471 1625681 Positive_regulation MED27 TNF 21904602 2550382 Positive_regulation MED27 TNF 22566867 899044 Positive_regulation MED27 TNF 22691272 126290 Positive_regulation MED27 TNF 22723832 2654727 Positive_regulation MED27 TNF 22723832 2654758 Positive_regulation MED27 TNF 23824685 2809200 Positive_regulation MED27 TNF 24300561 2247619 Positive_regulation MED27 TNF 24971461 2984481 Positive_regulation MED27 TNF 25275456 2373040 Positive_regulation MED27 TNF 3435705 443420 Positive_regulation MED27 TNF 7540649 1590339 Positive_regulation MED28 EDN2 9792333 1763723 Positive_regulation MED28 EPHB2 12769834 369145 Positive_regulation MED28 EPHB2 22216095 2584383 Positive_regulation MED28 EPHB2 22817771 471980 Positive_regulation MED28 RCAN1 19124655 1553425 Positive_regulation MED28 TLR7 18584038 3073065 Positive_regulation MED28 TLR7 18584038 3073817 Positive_regulation MED28 TLR7 18815618 631715 Positive_regulation MED28 TLR7 20871832 1748216 Positive_regulation MED28 TLR7 22785227 1919234 Positive_regulation MED28 TNF 22566867 899047 Positive_regulation MED28 TNF 23824685 2809203 Positive_regulation MED28 TNF 24300561 2247622 Positive_regulation MED28 TNF 24971461 2984490 Positive_regulation MED28 TNF 25275456 2373043 Positive_regulation MED28 TNF 3435705 443423 Positive_regulation MED28 TNF 7540649 1590342 Positive_regulation MED29 ALOX5 23991239 2372042 Positive_regulation MED29 CLU 23164821 1901044 Positive_regulation MED29 EDN2 9792333 1763699 Positive_regulation MED29 EPHB2 12769834 369135 Positive_regulation MED29 EPHB2 22216095 2584375 Positive_regulation MED29 EPHB2 22817771 471948 Positive_regulation MED29 IL1B 11132773 1737321 Positive_regulation MED29 RCAN1 19124655 1553417 Positive_regulation MED29 TLR7 15804356 3104429 Positive_regulation MED29 TLR7 18584038 3072985 Positive_regulation MED29 TLR7 18584038 3073737 Positive_regulation MED29 TLR7 18815618 631635 Positive_regulation MED29 TLR7 20871832 1748136 Positive_regulation MED29 TLR7 22691272 126276 Positive_regulation MED29 TLR7 22785227 1919146 Positive_regulation MED29 TNF 10408703 414838 Positive_regulation MED29 TNF 11132773 1737320 Positive_regulation MED29 TNF 18410682 110422 Positive_regulation MED29 TNF 18410682 110478 Positive_regulation MED29 TNF 21904602 2550377 Positive_regulation MED29 TNF 22566867 899039 Positive_regulation MED29 TNF 22691272 126275 Positive_regulation MED29 TNF 22723832 2654722 Positive_regulation MED29 TNF 22723832 2654753 Positive_regulation MED29 TNF 23824685 2809195 Positive_regulation MED29 TNF 24300561 2247614 Positive_regulation MED29 TNF 24971461 2984466 Positive_regulation MED29 TNF 25275456 2373035 Positive_regulation MED29 TNF 3435705 443415 Positive_regulation MED29 TNF 7540649 1590334 Positive_regulation MED30 ALOX5 23991239 2372041 Positive_regulation MED30 CLU 23164821 1901042 Positive_regulation MED30 EDN2 9792333 1763696 Positive_regulation MED30 EPHB2 12769834 369134 Positive_regulation MED30 EPHB2 22216095 2584374 Positive_regulation MED30 EPHB2 22817771 471944 Positive_regulation MED30 IL1B 11132773 1737319 Positive_regulation MED30 RCAN1 19124655 1553416 Positive_regulation MED30 TLR7 15804356 3104418 Positive_regulation MED30 TLR7 18584038 3072975 Positive_regulation MED30 TLR7 18584038 3073727 Positive_regulation MED30 TLR7 18815618 631625 Positive_regulation MED30 TLR7 20871832 1748126 Positive_regulation MED30 TLR7 22691272 126273 Positive_regulation MED30 TLR7 22785227 1919135 Positive_regulation MED30 TNF 10408703 414837 Positive_regulation MED30 TNF 11132773 1737318 Positive_regulation MED30 TNF 18410682 110421 Positive_regulation MED30 TNF 18410682 110477 Positive_regulation MED30 TNF 21904602 2550376 Positive_regulation MED30 TNF 22566867 899038 Positive_regulation MED30 TNF 22691272 126272 Positive_regulation MED30 TNF 22723832 2654721 Positive_regulation MED30 TNF 22723832 2654752 Positive_regulation MED30 TNF 23824685 2809194 Positive_regulation MED30 TNF 24300561 2247613 Positive_regulation MED30 TNF 24971461 2984463 Positive_regulation MED30 TNF 25275456 2373034 Positive_regulation MED30 TNF 3435705 443414 Positive_regulation MED30 TNF 7540649 1590333 Positive_regulation MED31 ALOX5 23991239 2372049 Positive_regulation MED31 CLU 23164821 1901058 Positive_regulation MED31 EDN2 9792333 1763720 Positive_regulation MED31 EPHB2 12769834 369144 Positive_regulation MED31 EPHB2 22216095 2584382 Positive_regulation MED31 EPHB2 22817771 471976 Positive_regulation MED31 IL1B 11132773 1737335 Positive_regulation MED31 RCAN1 19124655 1553424 Positive_regulation MED31 TLR7 15804356 3104506 Positive_regulation MED31 TLR7 18584038 3073055 Positive_regulation MED31 TLR7 18584038 3073807 Positive_regulation MED31 TLR7 18815618 631705 Positive_regulation MED31 TLR7 20871832 1748206 Positive_regulation MED31 TLR7 22691272 126297 Positive_regulation MED31 TLR7 22785227 1919223 Positive_regulation MED31 TNF 10408703 414845 Positive_regulation MED31 TNF 11132773 1737334 Positive_regulation MED31 TNF 18410682 110429 Positive_regulation MED31 TNF 18410682 110485 Positive_regulation MED31 TNF 19712471 1625683 Positive_regulation MED31 TNF 21904602 2550384 Positive_regulation MED31 TNF 22566867 899046 Positive_regulation MED31 TNF 22691272 126296 Positive_regulation MED31 TNF 22723832 2654729 Positive_regulation MED31 TNF 22723832 2654760 Positive_regulation MED31 TNF 23824685 2809202 Positive_regulation MED31 TNF 24300561 2247621 Positive_regulation MED31 TNF 24971461 2984487 Positive_regulation MED31 TNF 25275456 2373042 Positive_regulation MED31 TNF 3435705 443422 Positive_regulation MED31 TNF 7540649 1590341 Positive_regulation MED4 ALOX5 23991239 2372035 Positive_regulation MED4 ARSA 15824083 1535491 Positive_regulation MED4 CLU 23164821 1901030 Positive_regulation MED4 EDN2 9792333 1763675 Positive_regulation MED4 EPHB2 12769834 369127 Positive_regulation MED4 EPHB2 21559295 2518085 Positive_regulation MED4 EPHB2 21559295 2518103 Positive_regulation MED4 EPHB2 22216095 2584367 Positive_regulation MED4 EPHB2 22817771 471916 Positive_regulation MED4 EPHB2 24045785 3137114 Positive_regulation MED4 EPHB2 24045785 3137172 Positive_regulation MED4 IL1B 11132773 1737307 Positive_regulation MED4 RCAN1 19124655 1553409 Positive_regulation MED4 TLR7 15804356 3104352 Positive_regulation MED4 TLR7 18584038 3072905 Positive_regulation MED4 TLR7 18584038 3073657 Positive_regulation MED4 TLR7 18815618 631555 Positive_regulation MED4 TLR7 20871832 1748056 Positive_regulation MED4 TLR7 22691272 126255 Positive_regulation MED4 TLR7 22785227 1919058 Positive_regulation MED4 TNF 10408703 414831 Positive_regulation MED4 TNF 11132773 1737306 Positive_regulation MED4 TNF 18410682 110415 Positive_regulation MED4 TNF 18410682 110471 Positive_regulation MED4 TNF 19712471 1625667 Positive_regulation MED4 TNF 21904602 2550370 Positive_regulation MED4 TNF 22566867 899031 Positive_regulation MED4 TNF 22691272 126254 Positive_regulation MED4 TNF 22723832 2654715 Positive_regulation MED4 TNF 22723832 2654746 Positive_regulation MED4 TNF 23824685 2809187 Positive_regulation MED4 TNF 24300561 2247606 Positive_regulation MED4 TNF 24971461 2984442 Positive_regulation MED4 TNF 25275456 2373027 Positive_regulation MED4 TNF 3435705 443407 Positive_regulation MED4 TNF 7540649 1590326 Positive_regulation MED6 ALOX5 23991239 2372036 Positive_regulation MED6 ARSA 15824083 1535492 Positive_regulation MED6 CLU 23164821 1901032 Positive_regulation MED6 EDN2 9792333 1763681 Positive_regulation MED6 EPHB2 12769834 369129 Positive_regulation MED6 EPHB2 21559295 2518086 Positive_regulation MED6 EPHB2 21559295 2518104 Positive_regulation MED6 EPHB2 22216095 2584369 Positive_regulation MED6 EPHB2 22319481 860849 Positive_regulation MED6 EPHB2 22817771 471924 Positive_regulation MED6 EPHB2 24045785 3137115 Positive_regulation MED6 EPHB2 24045785 3137173 Positive_regulation MED6 EPHB2 24045785 3137174 Positive_regulation MED6 IL1B 11132773 1737309 Positive_regulation MED6 RCAN1 19124655 1553411 Positive_regulation MED6 TLR7 15804356 3104363 Positive_regulation MED6 TLR7 18584038 3072925 Positive_regulation MED6 TLR7 18584038 3073677 Positive_regulation MED6 TLR7 18815618 631575 Positive_regulation MED6 TLR7 20871832 1748076 Positive_regulation MED6 TLR7 22691272 126258 Positive_regulation MED6 TLR7 22785227 1919080 Positive_regulation MED6 TNF 10408703 414832 Positive_regulation MED6 TNF 11132773 1737308 Positive_regulation MED6 TNF 18410682 110416 Positive_regulation MED6 TNF 18410682 110472 Positive_regulation MED6 TNF 19712471 1625669 Positive_regulation MED6 TNF 21904602 2550371 Positive_regulation MED6 TNF 22566867 899033 Positive_regulation MED6 TNF 22691272 126257 Positive_regulation MED6 TNF 22723832 2654716 Positive_regulation MED6 TNF 22723832 2654747 Positive_regulation MED6 TNF 23824685 2809189 Positive_regulation MED6 TNF 24300561 2247608 Positive_regulation MED6 TNF 24971461 2984448 Positive_regulation MED6 TNF 25275456 2373029 Positive_regulation MED6 TNF 3435705 443409 Positive_regulation MED6 TNF 7540649 1590328 Positive_regulation MED7 ALOX5 23991239 2372048 Positive_regulation MED7 ARSA 15824083 1535499 Positive_regulation MED7 CLU 23164821 1901056 Positive_regulation MED7 EDN2 9792333 1763717 Positive_regulation MED7 EPHB2 12769834 369143 Positive_regulation MED7 EPHB2 21559295 2518094 Positive_regulation MED7 EPHB2 21559295 2518112 Positive_regulation MED7 EPHB2 22216095 2584381 Positive_regulation MED7 EPHB2 22319481 860863 Positive_regulation MED7 EPHB2 22817771 471972 Positive_regulation MED7 EPHB2 24045785 3137123 Positive_regulation MED7 EPHB2 24045785 3137188 Positive_regulation MED7 EPHB2 24045785 3137189 Positive_regulation MED7 IL1B 11132773 1737333 Positive_regulation MED7 RCAN1 19124655 1553423 Positive_regulation MED7 TLR7 15804356 3104495 Positive_regulation MED7 TLR7 18584038 3073045 Positive_regulation MED7 TLR7 18584038 3073797 Positive_regulation MED7 TLR7 18815618 631695 Positive_regulation MED7 TLR7 20871832 1748196 Positive_regulation MED7 TLR7 22691272 126294 Positive_regulation MED7 TLR7 22785227 1919212 Positive_regulation MED7 TNF 10408703 414844 Positive_regulation MED7 TNF 11132773 1737332 Positive_regulation MED7 TNF 18410682 110428 Positive_regulation MED7 TNF 18410682 110484 Positive_regulation MED7 TNF 21904602 2550383 Positive_regulation MED7 TNF 22566867 899045 Positive_regulation MED7 TNF 22691272 126293 Positive_regulation MED7 TNF 22723832 2654728 Positive_regulation MED7 TNF 22723832 2654759 Positive_regulation MED7 TNF 23824685 2809201 Positive_regulation MED7 TNF 24300561 2247620 Positive_regulation MED7 TNF 24971461 2984484 Positive_regulation MED7 TNF 25275456 2373041 Positive_regulation MED7 TNF 3435705 443421 Positive_regulation MED7 TNF 7540649 1590340 Positive_regulation MED8 ALOX5 23991239 2372037 Positive_regulation MED8 CLU 23164821 1901034 Positive_regulation MED8 EDN2 9792333 1763684 Positive_regulation MED8 EPHB2 12769834 369130 Positive_regulation MED8 EPHB2 21559295 2518087 Positive_regulation MED8 EPHB2 21559295 2518105 Positive_regulation MED8 EPHB2 22216095 2584370 Positive_regulation MED8 EPHB2 22817771 471928 Positive_regulation MED8 EPHB2 24045785 3137116 Positive_regulation MED8 EPHB2 24045785 3137175 Positive_regulation MED8 IL1B 11132773 1737311 Positive_regulation MED8 RCAN1 19124655 1553412 Positive_regulation MED8 TLR7 15804356 3104374 Positive_regulation MED8 TLR7 18584038 3072935 Positive_regulation MED8 TLR7 18584038 3073687 Positive_regulation MED8 TLR7 18815618 631585 Positive_regulation MED8 TLR7 20871832 1748086 Positive_regulation MED8 TLR7 22691272 126261 Positive_regulation MED8 TLR7 22785227 1919091 Positive_regulation MED8 TNF 10408703 414833 Positive_regulation MED8 TNF 11132773 1737310 Positive_regulation MED8 TNF 18410682 110417 Positive_regulation MED8 TNF 18410682 110473 Positive_regulation MED8 TNF 21904602 2550372 Positive_regulation MED8 TNF 22566867 899034 Positive_regulation MED8 TNF 22691272 126260 Positive_regulation MED8 TNF 22723832 2654717 Positive_regulation MED8 TNF 22723832 2654748 Positive_regulation MED8 TNF 23824685 2809190 Positive_regulation MED8 TNF 24300561 2247609 Positive_regulation MED8 TNF 24971461 2984451 Positive_regulation MED8 TNF 25275456 2373030 Positive_regulation MED8 TNF 3435705 443410 Positive_regulation MED8 TNF 7540649 1590329 Positive_regulation MED9 EDN2 9792333 1763726 Positive_regulation MED9 EPHB2 12769834 369146 Positive_regulation MED9 EPHB2 22216095 2584384 Positive_regulation MED9 EPHB2 22817771 471984 Positive_regulation MED9 RCAN1 19124655 1553426 Positive_regulation MED9 TLR7 18584038 3073075 Positive_regulation MED9 TLR7 18584038 3073827 Positive_regulation MED9 TLR7 18815618 631725 Positive_regulation MED9 TLR7 20871832 1748226 Positive_regulation MED9 TLR7 22785227 1919245 Positive_regulation MED9 TNF 22566867 899048 Positive_regulation MED9 TNF 23824685 2809204 Positive_regulation MED9 TNF 24300561 2247623 Positive_regulation MED9 TNF 24971461 2984493 Positive_regulation MED9 TNF 25275456 2373044 Positive_regulation MED9 TNF 3435705 443424 Positive_regulation MED9 TNF 7540649 1590343 Positive_regulation MEF2C LINC00284 24013378 1111862 Positive_regulation MEF2C LINC00341 24013378 1111822 Positive_regulation MEF2C MAP2K6 16478538 225488 Positive_regulation MEF2C MSX1 23280066 409343 Positive_regulation MEFV FHL1 24219103 151909 Positive_regulation MEFV FHL1 24219103 151910 Positive_regulation MEFV TNF 24199619 538024 Positive_regulation MEI1 TLR7 19564352 1555194 Positive_regulation MEI4 TLR7 19564352 1555204 Positive_regulation MEIS1 ITGA9 24391925 2904972 Positive_regulation MEIS1 MMP28 24642410 755450 Positive_regulation MEIS1 MMP7 24642410 755465 Positive_regulation MEIS2 ITGA9 24391925 2904974 Positive_regulation MET CAPN8 21765948 2536612 Positive_regulation MET EDN2 25356505 1133247 Positive_regulation MET EPHB2 24263233 840075 Positive_regulation MET EPHB2 24669959 400946 Positive_regulation MET EPHB2 24709879 617284 Positive_regulation MET FOXO1 12865925 422918 Positive_regulation MET GJB2 23750336 945369 Positive_regulation MET ID1 PMC4053215 477166 Positive_regulation MET ID1 PMC4053215 477167 Positive_regulation MET MAP2K6 24709879 617293 Positive_regulation MET MAP2K6 24807215 1942016 Positive_regulation MET MAP2K6 25337673 2205709 Positive_regulation MET TNF 25060092 850522 Positive_regulation METAP1D EPHB2 23815882 269083 Positive_regulation METAP1D MAP2K6 23815882 269089 Positive_regulation METAP2 EPHB2 17984326 1346309 Positive_regulation METAP2 NES 20634564 27548 Positive_regulation METAP2 WNT7A 25170755 3003863 Positive_regulation MFI2 FAM65B 21190562 1860637 Positive_regulation MFN2 PGC 18974884 2399740 Positive_regulation MFN2 PGC 18974884 2399741 Positive_regulation MFN2 PGC 18974884 2399742 Positive_regulation MFN2 PGC 18974884 2399743 Positive_regulation MFN2 PGC 18974884 2399744 Positive_regulation MFN2 PGC 18974884 2399745 Positive_regulation MFN2 PGC 18974884 2399750 Positive_regulation MFN2 PGC 18974884 2399752 Positive_regulation MFN2 PGC 18974884 2399754 Positive_regulation MFN2 PGC 21274278 1670136 Positive_regulation MFN2 PGC 22203837 832458 Positive_regulation MFN2 PGC 22769563 3161127 Positive_regulation MFN2 PGC 23211444 31078 Positive_regulation MFN2 PGC 23443131 1102637 Positive_regulation MGAT3 ARSA 24184502 154211 Positive_regulation MGAT3 ARSA 24184502 154219 Positive_regulation MGAT3 ARSA 24184502 154230 Positive_regulation MGAT3 ARSA 24184502 154231 Positive_regulation MGAT3 ARSA 24184502 154237 Positive_regulation MGAT3 ARSA 24184502 154241 Positive_regulation MGMT MMP7 23300791 2735968 Positive_regulation MGMT MMP7 23300791 2735969 Positive_regulation MGMT MMP7 23300791 2735986 Positive_regulation MGMT MMP7 23300791 2735988 Positive_regulation MIC12 PPBP 22761597 2336477 Positive_regulation MIC7 PPBP 22761597 2336478 Positive_regulation MICA EPHB2 24885711 273495 Positive_regulation MICA RAET1E 19997637 2433010 Positive_regulation MICE TLR7 22461749 3229310 Positive_regulation MICE TNF 9104810 1600611 Positive_regulation MICU1 CAPN8 18673549 290730 Positive_regulation MICU2 CAPN8 18673549 290758 Positive_regulation MICU3 CAPN8 18673549 290744 Positive_regulation MIEN1 PLAU 19503095 2125541 Positive_regulation MIF EPHB2 21283538 2495582 Positive_regulation MIF EPHB2 21283538 2495605 Positive_regulation MIF EPHB2 25015194 2195710 Positive_regulation MIF F2R 21209875 2491646 Positive_regulation MIF F2R 21209875 2491647 Positive_regulation MIF F2R 21209875 2491650 Positive_regulation MIF MMP28 19435478 113185 Positive_regulation MIF MMP7 19435478 113200 Positive_regulation MIF PGC 23823021 1497751 Positive_regulation MIF TLR7 18723565 90821 Positive_regulation MIF TNF 17029647 1727737 Positive_regulation MIF TNF 18475620 1744852 Positive_regulation MIF TNF 18723565 90810 Positive_regulation MIF TNF 18723565 90812 Positive_regulation MIF TNF 18723565 90815 Positive_regulation MIF TNF 20087353 434417 Positive_regulation MIF TNF 20939898 353734 Positive_regulation MIF TNF 21087445 645643 Positive_regulation MIF TNF 21087445 645648 Positive_regulation MIF TNF 21401926 121808 Positive_regulation MIF TNF 21977228 2559765 Positive_regulation MIF TNF 22096364 1628355 Positive_regulation MIF TNF 22096364 1628363 Positive_regulation MIF TNF 22952837 2684251 Positive_regulation MIF TNF 22952837 2684255 Positive_regulation MIF TNF 22973314 1068867 Positive_regulation MIF TNF 23527185 2770023 Positive_regulation MIF TNF 23675368 878568 Positive_regulation MIF TNF 23924945 1109765 Positive_regulation MIF TNF 25255103 3069565 Positive_regulation MIF TNF 8551232 1595847 Positive_regulation MIF TNF 8551232 1595852 Positive_regulation MIP ACSM3 20731855 659655 Positive_regulation MIP AKAP2 23734214 2799717 Positive_regulation MIP AKT1 21298000 2499266 Positive_regulation MIP AKT1 24009857 203920 Positive_regulation MIP AKT1 24009857 203942 Positive_regulation MIP AKT2 21298000 2499267 Positive_regulation MIP AKT2 24009857 203921 Positive_regulation MIP AKT2 24009857 203943 Positive_regulation MIP AKT3 21298000 2499268 Positive_regulation MIP AKT3 24009857 203922 Positive_regulation MIP AKT3 24009857 203944 Positive_regulation MIP APCS 10880527 1516081 Positive_regulation MIP AREG 18955794 1635061 Positive_regulation MIP ARHGEF7 22046194 633498 Positive_regulation MIP C5 23233853 905370 Positive_regulation MIP C5 24634797 21363 Positive_regulation MIP C5 24634797 21372 Positive_regulation MIP C5 24634797 21396 Positive_regulation MIP CALM3 23734214 2799697 Positive_regulation MIP CCR1 10377195 1512035 Positive_regulation MIP CCR5 23226201 2723571 Positive_regulation MIP CD40 21592361 3119662 Positive_regulation MIP CD40 21592361 3119670 Positive_regulation MIP CFTR 21301926 1050356 Positive_regulation MIP CFTR 24671173 2946578 Positive_regulation MIP CREB1 12204102 3103792 Positive_regulation MIP CREB3 12204102 3103793 Positive_regulation MIP CREB5 12204102 3103791 Positive_regulation MIP CRK 19781090 1625747 Positive_regulation MIP CRK 21682898 123011 Positive_regulation MIP CRK 22936947 882715 Positive_regulation MIP CSF2 18437014 1635019 Positive_regulation MIP CSF2 18437014 1635020 Positive_regulation MIP CSF2 18437014 1635021 Positive_regulation MIP CSF2 8315395 1594889 Positive_regulation MIP CSF2 8315395 1594896 Positive_regulation MIP CXCL11 22004287 3112839 Positive_regulation MIP CXCL9 22004287 3112840 Positive_regulation MIP CYSLTR1 23977066 2838282 Positive_regulation MIP DEFA1B 22080116 2242345 Positive_regulation MIP DEFA1B 22080116 2242346 Positive_regulation MIP EIF1 19413900 3109481 Positive_regulation MIP EPHB2 11877481 1523109 Positive_regulation MIP EPHB2 18523655 1908068 Positive_regulation MIP FAS 20565784 1626085 Positive_regulation MIP FAS 20565784 1626093 Positive_regulation MIP FGF2 21698120 2530414 Positive_regulation MIP FPR1 11877481 1523110 Positive_regulation MIP GIF 21777484 3091284 Positive_regulation MIP HAVCR2 25375372 578819 Positive_regulation MIP HMGB1 23991365 20556 Positive_regulation MIP HSPD1 15935092 3105023 Positive_regulation MIP IGKV1-17 21048992 2480386 Positive_regulation MIP IL10 17634143 108584 Positive_regulation MIP IL10 20544034 2452644 Positive_regulation MIP IL10 21777484 3091285 Positive_regulation MIP IL11 17634143 108585 Positive_regulation MIP IL12A 18809712 1552106 Positive_regulation MIP IL12A 24625974 572980 Positive_regulation MIP IL12A 24625974 572985 Positive_regulation MIP IL12B 18809712 1552107 Positive_regulation MIP IL12B 24625974 572981 Positive_regulation MIP IL12B 24625974 572986 Positive_regulation MIP IL13 17634143 108586 Positive_regulation MIP IL15 17634143 108587 Positive_regulation MIP IL15 21716670 1222205 Positive_regulation MIP IL15 24625974 572982 Positive_regulation MIP IL15 24625974 572987 Positive_regulation MIP IL16 17634143 108588 Positive_regulation MIP IL17A 20544034 2452645 Positive_regulation MIP IL17A 21699708 1626383 Positive_regulation MIP IL17A 21699708 1626387 Positive_regulation MIP IL17A 21699708 1626388 Positive_regulation MIP IL17A 21747807 923187 Positive_regulation MIP IL18 14970180 1531407 Positive_regulation MIP IL18 17634143 108589 Positive_regulation MIP IL18 18809712 1552108 Positive_regulation MIP IL18 21716670 1222206 Positive_regulation MIP IL19 17634143 108590 Positive_regulation MIP IL1A 11085746 1517930 Positive_regulation MIP IL1A 17145956 1543562 Positive_regulation MIP IL1A 21716670 1222207 Positive_regulation MIP IL1A 21777484 3091286 Positive_regulation MIP IL1A 22294049 1918687 Positive_regulation MIP IL1A 23717478 2797667 Positive_regulation MIP IL1A 24058610 2848253 Positive_regulation MIP IL1A 25546475 3036636 Positive_regulation MIP IL1A 25546475 3036637 Positive_regulation MIP IL2 17634143 108591 Positive_regulation MIP IL2 8760810 1598845 Positive_regulation MIP IL20 17634143 108592 Positive_regulation MIP IL21 17634143 108593 Positive_regulation MIP IL22 17634143 108576 Positive_regulation MIP IL24 17634143 108573 Positive_regulation MIP IL25 17634143 108575 Positive_regulation MIP IL26 17634143 108580 Positive_regulation MIP IL27 17634143 108581 Positive_regulation MIP IL3 17634143 108594 Positive_regulation MIP IL31 17634143 108582 Positive_regulation MIP IL32 16903774 2368854 Positive_regulation MIP IL32 17634143 108579 Positive_regulation MIP IL32 22613074 125948 Positive_regulation MIP IL32 22613074 125962 Positive_regulation MIP IL33 17634143 108578 Positive_regulation MIP IL33 23418608 2754895 Positive_regulation MIP IL34 17634143 108583 Positive_regulation MIP IL37 17634143 108577 Positive_regulation MIP IL4 17634143 108595 Positive_regulation MIP IL4 18955794 1635060 Positive_regulation MIP IL4 20544034 2452646 Positive_regulation MIP IL4 21777484 3091287 Positive_regulation MIP IL5 17634143 108596 Positive_regulation MIP IL6 17634143 108597 Positive_regulation MIP IL6 18483551 3041298 Positive_regulation MIP IL6 20380722 118646 Positive_regulation MIP IL6 24058610 2848254 Positive_regulation MIP IL7 17634143 108598 Positive_regulation MIP IL8 17634143 108599 Positive_regulation MIP IL8 21687657 2528761 Positive_regulation MIP IL9 17634143 108600 Positive_regulation MIP ISL1 23122226 1997896 Positive_regulation MIP ITIH4 20380698 3118845 Positive_regulation MIP LGALS9 25375372 578820 Positive_regulation MIP LTA 19175917 352574 Positive_regulation MIP LTA 24288685 185464 Positive_regulation MIP MAF 17262012 1906209 Positive_regulation MIP MAF 17262012 1906281 Positive_regulation MIP MAPK1 19781090 1625749 Positive_regulation MIP MAPK1 19781090 1625777 Positive_regulation MIP MAPK1 21977329 1082357 Positive_regulation MIP MAPK1 22936947 882717 Positive_regulation MIP MAPK1 24376630 2901550 Positive_regulation MIP MAPK10 19781090 1625750 Positive_regulation MIP MAPK10 19781090 1625778 Positive_regulation MIP MAPK10 21977329 1082358 Positive_regulation MIP MAPK10 22936947 882718 Positive_regulation MIP MAPK10 24376630 2901551 Positive_regulation MIP MAPK11 19781090 1625751 Positive_regulation MIP MAPK11 19781090 1625779 Positive_regulation MIP MAPK11 21977329 1082359 Positive_regulation MIP MAPK11 22936947 882719 Positive_regulation MIP MAPK11 24376630 2901552 Positive_regulation MIP MAPK12 19781090 1625752 Positive_regulation MIP MAPK12 19781090 1625780 Positive_regulation MIP MAPK12 21977329 1082360 Positive_regulation MIP MAPK12 22936947 882720 Positive_regulation MIP MAPK12 24376630 2901553 Positive_regulation MIP MAPK13 19781090 1625753 Positive_regulation MIP MAPK13 19781090 1625781 Positive_regulation MIP MAPK13 21977329 1082361 Positive_regulation MIP MAPK13 22936947 882721 Positive_regulation MIP MAPK13 24376630 2901554 Positive_regulation MIP MAPK14 19781090 1625754 Positive_regulation MIP MAPK14 19781090 1625782 Positive_regulation MIP MAPK14 21977329 1082362 Positive_regulation MIP MAPK14 22936947 882722 Positive_regulation MIP MAPK14 24376630 2901555 Positive_regulation MIP MAPK15 19781090 1625748 Positive_regulation MIP MAPK15 19781090 1625776 Positive_regulation MIP MAPK15 21977329 1082356 Positive_regulation MIP MAPK15 22936947 882716 Positive_regulation MIP MAPK15 24376630 2901549 Positive_regulation MIP MAPK3 17316425 658807 Positive_regulation MIP MAPK3 17316425 658809 Positive_regulation MIP MAPK3 19781090 1625755 Positive_regulation MIP MAPK3 19781090 1625783 Positive_regulation MIP MAPK3 21977329 1082363 Positive_regulation MIP MAPK3 22379572 1710334 Positive_regulation MIP MAPK3 22936947 882723 Positive_regulation MIP MAPK3 24376630 2901556 Positive_regulation MIP MAPK4 19781090 1625756 Positive_regulation MIP MAPK4 19781090 1625784 Positive_regulation MIP MAPK4 21977329 1082364 Positive_regulation MIP MAPK4 22936947 882724 Positive_regulation MIP MAPK4 24376630 2901557 Positive_regulation MIP MAPK6 19781090 1625757 Positive_regulation MIP MAPK6 19781090 1625785 Positive_regulation MIP MAPK6 21977329 1082365 Positive_regulation MIP MAPK6 22936947 882725 Positive_regulation MIP MAPK6 24376630 2901558 Positive_regulation MIP MAPK7 19781090 1625758 Positive_regulation MIP MAPK7 19781090 1625786 Positive_regulation MIP MAPK7 21977329 1082366 Positive_regulation MIP MAPK7 22936947 882726 Positive_regulation MIP MAPK7 24376630 2901559 Positive_regulation MIP MAPK8 19781090 1625759 Positive_regulation MIP MAPK8 19781090 1625787 Positive_regulation MIP MAPK8 21977329 1082367 Positive_regulation MIP MAPK8 22936947 882727 Positive_regulation MIP MAPK8 24376630 2901560 Positive_regulation MIP MAPK9 19781090 1625760 Positive_regulation MIP MAPK9 19781090 1625788 Positive_regulation MIP MAPK9 21977329 1082368 Positive_regulation MIP MAPK9 22936947 882728 Positive_regulation MIP MAPK9 24376630 2901561 Positive_regulation MIP MIF 19413900 3109417 Positive_regulation MIP MIF 19413900 3109418 Positive_regulation MIP MIF 19413900 3109482 Positive_regulation MIP MPO 21906393 1229625 Positive_regulation MIP MYD88 16304610 3039065 Positive_regulation MIP MYD88 24288685 185465 Positive_regulation MIP NELFCD 21984926 2561229 Positive_regulation MIP NFATC1 22792407 2663632 Positive_regulation MIP NFKB1 9788893 798123 Positive_regulation MIP NKRF 23840526 2814930 Positive_regulation MIP NLRC4 25232720 2372946 Positive_regulation MIP NOS2 12438423 1525350 Positive_regulation MIP P2RX7 18553155 3090131 Positive_regulation MIP PAM 20403209 396225 Positive_regulation MIP PDLIM7 21592361 3119663 Positive_regulation MIP PDLIM7 21592361 3119671 Positive_regulation MIP PI3 19781090 1625761 Positive_regulation MIP PIK3CA 24009857 203945 Positive_regulation MIP PIK3R1 24009857 203946 Positive_regulation MIP PITX3 21698120 2530409 Positive_regulation MIP PLA2G4A 23670971 727354 Positive_regulation MIP POLDIP2 24376630 2901548 Positive_regulation MIP PRKACB 22095752 776882 Positive_regulation MIP PRKACB 23734214 2799698 Positive_regulation MIP PRKACB 23734214 2799718 Positive_regulation MIP PRKACG 22095752 776883 Positive_regulation MIP PRKACG 23734214 2799699 Positive_regulation MIP PRKACG 23734214 2799719 Positive_regulation MIP PRKAR1A 22095752 776884 Positive_regulation MIP PRKAR1A 23734214 2799700 Positive_regulation MIP PRKAR1A 23734214 2799720 Positive_regulation MIP PRKAR1B 22095752 776885 Positive_regulation MIP PRKAR1B 23734214 2799701 Positive_regulation MIP PRKAR1B 23734214 2799721 Positive_regulation MIP PRKAR2A 22095752 776886 Positive_regulation MIP PRKAR2A 23734214 2799702 Positive_regulation MIP PRKAR2A 23734214 2799722 Positive_regulation MIP PRKAR2B 22095752 776887 Positive_regulation MIP PRKAR2B 23734214 2799703 Positive_regulation MIP PRKAR2B 23734214 2799723 Positive_regulation MIP RBM5 23147374 808701 Positive_regulation MIP RELA 9788893 798124 Positive_regulation MIP RNASE3 1281207 1527720 Positive_regulation MIP RNF19A 18046891 1071400 Positive_regulation MIP S100A9 23029038 2694323 Positive_regulation MIP SDS 16740164 356731 Positive_regulation MIP SEA 8496676 1595577 Positive_regulation MIP SEA 8496676 1595578 Positive_regulation MIP SF3B3 19665392 694866 Positive_regulation MIP SIGLEC7 23029261 2695730 Positive_regulation MIP SYT1 22187158 2070758 Positive_regulation MIP TAT 22187158 2070743 Positive_regulation MIP TAT 22187158 2070759 Positive_regulation MIP TBK1 23721397 1626994 Positive_regulation MIP TLR1 22193989 488200 Positive_regulation MIP TLR1 22193989 488241 Positive_regulation MIP TLR1 25071732 926982 Positive_regulation MIP TLR10 22193989 488208 Positive_regulation MIP TLR10 22193989 488249 Positive_regulation MIP TLR10 25071732 926990 Positive_regulation MIP TLR2 22193989 488201 Positive_regulation MIP TLR2 22193989 488242 Positive_regulation MIP TLR2 25071732 926983 Positive_regulation MIP TLR3 22193989 488202 Positive_regulation MIP TLR3 22193989 488243 Positive_regulation MIP TLR3 25071732 926984 Positive_regulation MIP TLR4 15935092 3105022 Positive_regulation MIP TLR4 16827942 3107333 Positive_regulation MIP TLR4 22193989 488203 Positive_regulation MIP TLR4 22193989 488244 Positive_regulation MIP TLR4 23028609 2691900 Positive_regulation MIP TLR4 24434316 1045860 Positive_regulation MIP TLR4 25071732 926985 Positive_regulation MIP TLR5 22193989 488204 Positive_regulation MIP TLR5 22193989 488245 Positive_regulation MIP TLR5 25071732 926986 Positive_regulation MIP TLR6 22193989 488209 Positive_regulation MIP TLR6 22193989 488250 Positive_regulation MIP TLR6 25071732 926991 Positive_regulation MIP TLR7 22193989 488205 Positive_regulation MIP TLR7 22193989 488246 Positive_regulation MIP TLR7 23028609 2691860 Positive_regulation MIP TLR7 25071732 926987 Positive_regulation MIP TLR8 22193989 488206 Positive_regulation MIP TLR8 22193989 488247 Positive_regulation MIP TLR8 25071732 926988 Positive_regulation MIP TLR9 22193989 488207 Positive_regulation MIP TLR9 22193989 488248 Positive_regulation MIP TLR9 25071732 926989 Positive_regulation MIP TNF 17634143 108574 Positive_regulation MIP TNF 19901996 1746818 Positive_regulation MIP TNF 20980218 794149 Positive_regulation MIP TNF 21301926 1050347 Positive_regulation MIP TNF 21933242 641155 Positive_regulation MIP TNF 22240205 1660639 Positive_regulation MIP TNF 23028874 2693485 Positive_regulation MIP TNF 24058610 2848252 Positive_regulation MIP TNF 7500047 1588526 Positive_regulation MIP TNF 7500047 1588532 Positive_regulation MIP TNF 7500047 1588537 Positive_regulation MIP TNF 9400717 797369 Positive_regulation MIP TNFRSF9 20544034 2452660 Positive_regulation MIP TNFRSF9 20544034 2452662 Positive_regulation MIP TNPO1 20380722 118647 Positive_regulation MIP TNPO1 21301926 1050348 Positive_regulation MIP TNPO1 24058610 2848255 Positive_regulation MIP TSPAN31 24524655 291174 Positive_regulation MIP WNK1 19338389 2266475 Positive_regulation MIP XCL1 20544034 2452643 Positive_regulation MIPEP EPHB2 18523655 1908069 Positive_regulation MIPEP MIP 24381939 186011 Positive_regulation MIPEP TLR7 19325820 1087889 Positive_regulation MIPEP TLR7 23028609 2691861 Positive_regulation MIPEP TLR7 25071732 926997 Positive_regulation MIPEP TNF 11085746 1517931 Positive_regulation MIPEP TNF 21857970 2544515 Positive_regulation MIPEP TNF 22110387 1058546 Positive_regulation MIPEP TNF 22187158 2070776 Positive_regulation MIR133A1 CTGF 24937684 1127845 Positive_regulation MIR133A2 CTGF 24937684 1127848 Positive_regulation MIR155 TLR7 22785227 1919300 Positive_regulation MIR181C TNF 22950459 1665011 Positive_regulation MIR18A TNF 25165988 133019 Positive_regulation MIR205 TP63 24598126 1618787 Positive_regulation MIR27A CCND1 23240057 2727720 Positive_regulation MIR330 EPHB2 24736727 2953496 Positive_regulation MITF EDN2 23884103 220663 Positive_regulation MITF EPHB2 16129781 1323443 Positive_regulation MITF EPHB2 18628967 2392844 Positive_regulation MITF EPHB2 21838918 1229403 Positive_regulation MITF EPHB2 21887372 2549619 Positive_regulation MITF EPHB2 22363147 88173 Positive_regulation MITF EPHB2 22536322 2621984 Positive_regulation MITF EPHB2 22915995 1714348 Positive_regulation MITF EPHB2 23123645 16505 Positive_regulation MITF EPHB2 23261059 219940 Positive_regulation MITF EPHB2 23736765 1729774 Positive_regulation MITF EPHB2 23935660 822065 Positive_regulation MITF EPHB2 24129178 1113318 Positive_regulation MITF EPHB2 24564864 484257 Positive_regulation MITF EPHB2 25045707 195102 Positive_regulation MITF EPHB2 25196602 1129859 Positive_regulation MITF GPNMB 21209915 2492426 Positive_regulation MITF MAP2K6 16129781 1323449 Positive_regulation MITF MAP2K6 21887372 2549688 Positive_regulation MITF MAP2K6 22536322 2621990 Positive_regulation MITF MAP2K6 23123645 16511 Positive_regulation MITF MAP2K6 24129178 1113324 Positive_regulation MITF MAP2K6 24823877 1126547 Positive_regulation MKNK1 EPHB2 16984645 279361 Positive_regulation MKNK1 EPHB2 17622349 2376990 Positive_regulation MKNK1 EPHB2 19300492 3043443 Positive_regulation MKNK1 EPHB2 19690847 828902 Positive_regulation MKNK1 EPHB2 22392765 2179855 Positive_regulation MKNK1 EPHB2 23275061 1148212 Positive_regulation MKNK1 MAP2K6 16984645 279367 Positive_regulation MKNK1 MAP2K6 20226096 1228033 Positive_regulation MKNK1 MAP2K6 24192080 1870213 Positive_regulation MKNK1 TLR7 22610140 1957387 Positive_regulation MLKL TNF 24090154 537732 Positive_regulation MLKL TNF 24328763 451540 Positive_regulation MLKL TNF 24366341 612184 Positive_regulation MLST8 CCND1 22359572 2597711 Positive_regulation MLST8 EPHB2 21200439 2489533 Positive_regulation MLST8 EPHB2 21283628 2496970 Positive_regulation MLST8 EPHB2 21738705 2533405 Positive_regulation MLST8 EPHB2 22028687 860487 Positive_regulation MLST8 EPHB2 22028687 860560 Positive_regulation MLST8 EPHB2 22880048 2673710 Positive_regulation MLST8 EPHB2 23431403 2755365 Positive_regulation MLST8 EPHB2 23431403 2755428 Positive_regulation MLST8 EPHB2 23431403 2755438 Positive_regulation MLST8 EPHB2 23624914 2152074 Positive_regulation MLST8 EPHB2 23624914 2152087 Positive_regulation MLST8 EPHB2 23862076 2003107 Positive_regulation MLST8 EPHB2 24303063 2887904 Positive_regulation MLST8 EPHB2 24612393 1692519 Positive_regulation MLST8 EPHB2 24710474 618064 Positive_regulation MLST8 EPHB2 24710474 618106 Positive_regulation MLST8 FOXO1 23875175 945959 Positive_regulation MLST8 FOXO1 24228024 694173 Positive_regulation MLST8 MAP2K6 21738705 2533411 Positive_regulation MLST8 RAB31 22523661 1670278 Positive_regulation MLST8 TLR7 24740015 2954016 Positive_regulation MLXIPL CCND1 22751438 541612 Positive_regulation MLXIPL CCND1 22751438 541622 Positive_regulation MLXIPL CCND1 22951541 541912 Positive_regulation MLXIPL FOXO1 23056614 2702408 Positive_regulation MLXIPL FOXO1 25250015 881136 Positive_regulation MLXIPL FOXO1 25250015 881155 Positive_regulation MLYCD LBP 7504060 1588756 Positive_regulation MME EPHB2 22767595 1204012 Positive_regulation MME ITGAL 22015609 547590 Positive_regulation MME MAP2K6 22767595 1204018 Positive_regulation MME MMP28 22642296 1230704 Positive_regulation MME MMP7 22642296 1230719 Positive_regulation MMP1 ABCA4 23805043 1915997 Positive_regulation MMP1 AGR2 17129374 107081 Positive_regulation MMP1 AGR2 17129374 107082 Positive_regulation MMP1 CAPN8 18493299 2388964 Positive_regulation MMP1 CAPN8 21911754 720056 Positive_regulation MMP1 CCND1 22942717 1097088 Positive_regulation MMP1 EPHB2 18629305 793135 Positive_regulation MMP1 EPHB2 20102637 1853214 Positive_regulation MMP1 EPHB2 21143918 1860595 Positive_regulation MMP1 EPHB2 21143918 1860596 Positive_regulation MMP1 EPHB2 21738525 922797 Positive_regulation MMP1 EPHB2 22310287 2146201 Positive_regulation MMP1 EPHB2 23193473 1139779 Positive_regulation MMP1 EPHB2 23637886 2786434 Positive_regulation MMP1 EPHB2 23663277 1678762 Positive_regulation MMP1 EPHB2 23671446 95493 Positive_regulation MMP1 EPHB2 24084727 1113131 Positive_regulation MMP1 EPHB2 24352036 1632438 Positive_regulation MMP1 EPHB2 24352036 1632450 Positive_regulation MMP1 F2R 19734937 2126738 Positive_regulation MMP1 F2R 19734937 2126739 Positive_regulation MMP1 F2R 19734937 2126745 Positive_regulation MMP1 F2R 19734937 2126746 Positive_regulation MMP1 F2R 19734937 2126747 Positive_regulation MMP1 F2R 19734937 2126753 Positive_regulation MMP1 F2R 19734937 2126754 Positive_regulation MMP1 F2R 19734937 2126755 Positive_regulation MMP1 F2R 19734937 2126764 Positive_regulation MMP1 F2R 21591259 776199 Positive_regulation MMP1 F2R 21591259 776225 Positive_regulation MMP1 F2R 21591260 776260 Positive_regulation MMP1 F2R 21966428 2557683 Positive_regulation MMP1 F2R 22992722 988776 Positive_regulation MMP1 F2R 23270594 660387 Positive_regulation MMP1 GPR115 24066041 2849183 Positive_regulation MMP1 GPR132 24066041 2849172 Positive_regulation MMP1 GPR87 24066041 2849252 Positive_regulation MMP1 HBEGF 21179550 2489193 Positive_regulation MMP1 IL1B 11720451 420174 Positive_regulation MMP1 IL1B 15203568 1739662 Positive_regulation MMP1 IL1B 15203568 1739698 Positive_regulation MMP1 IL1B 23613752 2782097 Positive_regulation MMP1 IL1B 25424126 133909 Positive_regulation MMP1 IL1B 25424126 133919 Positive_regulation MMP1 IL1B 25562599 3037226 Positive_regulation MMP1 IL1B 25562599 3037233 Positive_regulation MMP1 IL1B 25562599 3037243 Positive_regulation MMP1 MAP2K6 20667128 1857528 Positive_regulation MMP1 MAP2K6 21371008 450995 Positive_regulation MMP1 MIP 21347304 2503597 Positive_regulation MMP1 MMP28 20856827 1071752 Positive_regulation MMP1 MMP28 8554978 445157 Positive_regulation MMP1 MMP28 PMC4062143 99591 Positive_regulation MMP1 MMP7 17623071 3096473 Positive_regulation MMP1 MMP7 20856827 1071767 Positive_regulation MMP1 MMP7 21455784 2012503 Positive_regulation MMP1 MMP7 23840737 2816258 Positive_regulation MMP1 MMP7 24273653 2251311 Positive_regulation MMP1 MMP7 24519465 2243673 Positive_regulation MMP1 MMP7 8554978 445173 Positive_regulation MMP1 MMP7 PMC4062143 99606 Positive_regulation MMP1 MUC16 23694968 3135788 Positive_regulation MMP1 NES 24819052 2968705 Positive_regulation MMP1 PECAM1 12591918 1291185 Positive_regulation MMP1 PLAT 23977299 2839943 Positive_regulation MMP1 PLAT 24303218 2003288 Positive_regulation MMP1 PLAU 24189182 787863 Positive_regulation MMP1 PLAU 9083329 446102 Positive_regulation MMP1 TFPI2 23905012 853446 Positive_regulation MMP1 TFPI2 PMC2756345 496070 Positive_regulation MMP1 TGM2 24130925 204504 Positive_regulation MMP1 TLR7 17129374 107220 Positive_regulation MMP1 TLR7 23940584 2831676 Positive_regulation MMP1 TNF 11879548 98694 Positive_regulation MMP1 TNF 14651749 3095622 Positive_regulation MMP1 TNF 14979937 100161 Positive_regulation MMP1 TNF 15987479 103893 Positive_regulation MMP1 TNF 16879746 106493 Positive_regulation MMP1 TNF 17118171 3096352 Positive_regulation MMP1 TNF 18237379 379285 Positive_regulation MMP1 TNF 19226472 112822 Positive_regulation MMP1 TNF 19226472 112823 Positive_regulation MMP1 TNF 19226472 112892 Positive_regulation MMP1 TNF 19281072 1071666 Positive_regulation MMP1 TNF 19296842 112994 Positive_regulation MMP1 TNF 19435506 113259 Positive_regulation MMP1 TNF 19435506 113289 Positive_regulation MMP1 TNF 19627579 116162 Positive_regulation MMP1 TNF 19787068 2427376 Positive_regulation MMP1 TNF 19787068 2427379 Positive_regulation MMP1 TNF 19787068 2427380 Positive_regulation MMP1 TNF 19787068 2427383 Positive_regulation MMP1 TNF 19889233 3097666 Positive_regulation MMP1 TNF 20126546 2439114 Positive_regulation MMP1 TNF 20126546 2439161 Positive_regulation MMP1 TNF 20429888 118780 Positive_regulation MMP1 TNF 20543948 2452479 Positive_regulation MMP1 TNF 20836843 120093 Positive_regulation MMP1 TNF 20843335 1626169 Positive_regulation MMP1 TNF 20871770 1047097 Positive_regulation MMP1 TNF 21067565 397472 Positive_regulation MMP1 TNF 21294864 121400 Positive_regulation MMP1 TNF 21345249 121580 Positive_regulation MMP1 TNF 21912722 2223877 Positive_regulation MMP1 TNF 22005011 1697937 Positive_regulation MMP1 TNF 22315682 1687122 Positive_regulation MMP1 TNF 22367096 650836 Positive_regulation MMP1 TNF 22367096 650838 Positive_regulation MMP1 TNF 22367096 650840 Positive_regulation MMP1 TNF 22778767 636634 Positive_regulation MMP1 TNF 23441116 1915727 Positive_regulation MMP1 TNF 23533687 2225597 Positive_regulation MMP1 TNF 23784308 606156 Positive_regulation MMP1 TNF 23840095 1753414 Positive_regulation MMP1 TNF 23924945 1109773 Positive_regulation MMP1 TNF 24062615 1628847 Positive_regulation MMP1 TNF 24062615 1628895 Positive_regulation MMP1 TNF 24151615 184546 Positive_regulation MMP1 TNF 24194717 858708 Positive_regulation MMP1 TNF 24236107 2878530 Positive_regulation MMP1 TNF 24278882 1498594 Positive_regulation MMP1 TNF 24284399 1121774 Positive_regulation MMP1 TNF 24289089 131076 Positive_regulation MMP1 TNF 24498364 2919255 Positive_regulation MMP1 TNF 24552146 295831 Positive_regulation MMP1 TNF 24552146 295838 Positive_regulation MMP1 TNF 24552146 295843 Positive_regulation MMP1 TNF 24762063 401030 Positive_regulation MMP1 TNF 24887434 132702 Positive_regulation MMP1 TNF 24926361 844309 Positive_regulation MMP1 TNF 24977073 1154291 Positive_regulation MMP1 TNF 25109503 3114690 Positive_regulation MMP1 TNF 25143751 645531 Positive_regulation MMP1 TNF 25147435 1761204 Positive_regulation MMP1 TNF 25250141 1148958 Positive_regulation MMP1 TNF 25356505 1133257 Positive_regulation MMP1 TNF 25457675 805865 Positive_regulation MMP1 TNF PMC2834114 134584 Positive_regulation MMP1 TSPAN1 23840773 2817004 Positive_regulation MMP1 WNT7A 24479426 131491 Positive_regulation MMP10 AGR2 17129374 107085 Positive_regulation MMP10 AGR2 17129374 107086 Positive_regulation MMP10 CAPN8 18493299 2388978 Positive_regulation MMP10 CAPN8 21911754 720071 Positive_regulation MMP10 CCND1 22942717 1097089 Positive_regulation MMP10 EPHB2 18629305 793138 Positive_regulation MMP10 EPHB2 21738525 922798 Positive_regulation MMP10 EPHB2 22310287 2146202 Positive_regulation MMP10 EPHB2 23663277 1678764 Positive_regulation MMP10 EPHB2 23671446 95507 Positive_regulation MMP10 EPHB2 24084727 1113133 Positive_regulation MMP10 GPR115 24066041 2849276 Positive_regulation MMP10 GPR132 24066041 2849265 Positive_regulation MMP10 GPR87 24066041 2849345 Positive_regulation MMP10 HBEGF 21179550 2489195 Positive_regulation MMP10 IL1B 15203568 1739663 Positive_regulation MMP10 MAP2K6 20667128 1857536 Positive_regulation MMP10 MIP 21347304 2503598 Positive_regulation MMP10 MUC16 23694968 3135789 Positive_regulation MMP10 PECAM1 12591918 1291186 Positive_regulation MMP10 PLAT 23977299 2839944 Positive_regulation MMP10 PLAT 24303218 2003289 Positive_regulation MMP10 PLAU 24189182 787864 Positive_regulation MMP10 PLAU 9083329 446104 Positive_regulation MMP10 TFPI2 23905012 853447 Positive_regulation MMP10 TFPI2 PMC2756345 496072 Positive_regulation MMP10 TGM2 24130925 204505 Positive_regulation MMP10 TLR7 17129374 107230 Positive_regulation MMP10 TLR7 23940584 2831686 Positive_regulation MMP10 TNF 11237387 418343 Positive_regulation MMP10 TNF 11237387 418344 Positive_regulation MMP10 TNF 11237387 418348 Positive_regulation MMP10 TNF 14979937 100162 Positive_regulation MMP10 TNF 15987479 103895 Positive_regulation MMP10 TNF 17118171 3096353 Positive_regulation MMP10 TNF 18237379 379286 Positive_regulation MMP10 TNF 19226472 112828 Positive_regulation MMP10 TNF 19281072 1071667 Positive_regulation MMP10 TNF 19435506 113260 Positive_regulation MMP10 TNF 19889233 3097667 Positive_regulation MMP10 TNF 20126546 2439115 Positive_regulation MMP10 TNF 20126546 2439162 Positive_regulation MMP10 TNF 20543948 2452481 Positive_regulation MMP10 TNF 20871770 1047098 Positive_regulation MMP10 TNF 21912722 2223878 Positive_regulation MMP10 TNF 22005011 1697938 Positive_regulation MMP10 TNF 22315682 1687123 Positive_regulation MMP10 TNF 22778767 636635 Positive_regulation MMP10 TNF 23441116 1915728 Positive_regulation MMP10 TNF 23533687 2225598 Positive_regulation MMP10 TNF 23924945 1109774 Positive_regulation MMP10 TNF 24236107 2878532 Positive_regulation MMP10 TNF 24278882 1498595 Positive_regulation MMP10 TNF 24762063 401031 Positive_regulation MMP10 TNF 24926361 844321 Positive_regulation MMP10 TNF 24977073 1154294 Positive_regulation MMP10 TNF 25143751 645534 Positive_regulation MMP10 TNF 25147435 1761205 Positive_regulation MMP10 TNF 25250141 1148959 Positive_regulation MMP10 TNF 25356505 1133278 Positive_regulation MMP10 TSPAN1 23840773 2817026 Positive_regulation MMP10 WNT7A 24479426 131493 Positive_regulation MMP11 AGR2 17129374 107089 Positive_regulation MMP11 AGR2 17129374 107090 Positive_regulation MMP11 CAPN8 18493299 2388992 Positive_regulation MMP11 CAPN8 21911754 720086 Positive_regulation MMP11 CCND1 22942717 1097090 Positive_regulation MMP11 EPHB2 18629305 793141 Positive_regulation MMP11 EPHB2 21738525 922799 Positive_regulation MMP11 EPHB2 22310287 2146203 Positive_regulation MMP11 EPHB2 23663277 1678766 Positive_regulation MMP11 EPHB2 23671446 95521 Positive_regulation MMP11 EPHB2 24084727 1113135 Positive_regulation MMP11 GPR115 24066041 2849369 Positive_regulation MMP11 GPR132 24066041 2849358 Positive_regulation MMP11 GPR87 24066041 2849438 Positive_regulation MMP11 HBEGF 21179550 2489197 Positive_regulation MMP11 IL1B 15203568 1739664 Positive_regulation MMP11 MAP2K6 20667128 1857544 Positive_regulation MMP11 MIP 21347304 2503599 Positive_regulation MMP11 MUC16 23694968 3135790 Positive_regulation MMP11 PECAM1 12591918 1291187 Positive_regulation MMP11 PLAT 23977299 2839945 Positive_regulation MMP11 PLAT 24303218 2003290 Positive_regulation MMP11 PLAU 24189182 787865 Positive_regulation MMP11 PLAU 9083329 446106 Positive_regulation MMP11 TFPI2 23905012 853448 Positive_regulation MMP11 TFPI2 PMC2756345 496074 Positive_regulation MMP11 TGM2 24130925 204506 Positive_regulation MMP11 TLR7 17129374 107240 Positive_regulation MMP11 TLR7 23940584 2831696 Positive_regulation MMP11 TNF 14979937 100163 Positive_regulation MMP11 TNF 15987479 103897 Positive_regulation MMP11 TNF 17118171 3096354 Positive_regulation MMP11 TNF 18237379 379287 Positive_regulation MMP11 TNF 19226472 112832 Positive_regulation MMP11 TNF 19281072 1071668 Positive_regulation MMP11 TNF 19435506 113261 Positive_regulation MMP11 TNF 19889233 3097668 Positive_regulation MMP11 TNF 20126546 2439116 Positive_regulation MMP11 TNF 20126546 2439163 Positive_regulation MMP11 TNF 20543948 2452483 Positive_regulation MMP11 TNF 20871770 1047099 Positive_regulation MMP11 TNF 21912722 2223879 Positive_regulation MMP11 TNF 22005011 1697939 Positive_regulation MMP11 TNF 22190977 633861 Positive_regulation MMP11 TNF 22315682 1687124 Positive_regulation MMP11 TNF 22778767 636636 Positive_regulation MMP11 TNF 23441116 1915729 Positive_regulation MMP11 TNF 23533687 2225599 Positive_regulation MMP11 TNF 23924945 1109775 Positive_regulation MMP11 TNF 24236107 2878534 Positive_regulation MMP11 TNF 24278882 1498596 Positive_regulation MMP11 TNF 24762063 401032 Positive_regulation MMP11 TNF 24926361 844333 Positive_regulation MMP11 TNF 24977073 1154297 Positive_regulation MMP11 TNF 25143751 645537 Positive_regulation MMP11 TNF 25147435 1761206 Positive_regulation MMP11 TNF 25250141 1148960 Positive_regulation MMP11 TNF 25356505 1133285 Positive_regulation MMP11 TSPAN1 23840773 2817048 Positive_regulation MMP11 WNT7A 24479426 131495 Positive_regulation MMP12 AGR2 17129374 107093 Positive_regulation MMP12 AGR2 17129374 107094 Positive_regulation MMP12 CAPN8 18493299 2389006 Positive_regulation MMP12 CAPN8 21911754 720101 Positive_regulation MMP12 CCND1 22942717 1097091 Positive_regulation MMP12 EPHB2 18629305 793144 Positive_regulation MMP12 EPHB2 21738525 922800 Positive_regulation MMP12 EPHB2 22310287 2146204 Positive_regulation MMP12 EPHB2 23663277 1678768 Positive_regulation MMP12 EPHB2 23671446 95535 Positive_regulation MMP12 EPHB2 24084727 1113137 Positive_regulation MMP12 GPR115 24066041 2849462 Positive_regulation MMP12 GPR132 24066041 2849451 Positive_regulation MMP12 GPR87 24066041 2849531 Positive_regulation MMP12 HBEGF 21179550 2489199 Positive_regulation MMP12 IL1B 15203568 1739665 Positive_regulation MMP12 MAP2K6 20667128 1857552 Positive_regulation MMP12 MIP 21347304 2503600 Positive_regulation MMP12 MUC16 23694968 3135791 Positive_regulation MMP12 PECAM1 12591918 1291188 Positive_regulation MMP12 PLAT 23977299 2839946 Positive_regulation MMP12 PLAT 24303218 2003291 Positive_regulation MMP12 PLAU 24189182 787866 Positive_regulation MMP12 PLAU 9083329 446108 Positive_regulation MMP12 TFPI2 23905012 853449 Positive_regulation MMP12 TFPI2 PMC2756345 496076 Positive_regulation MMP12 TGM2 24130925 204507 Positive_regulation MMP12 TLR7 17129374 107250 Positive_regulation MMP12 TLR7 23940584 2831706 Positive_regulation MMP12 TNF 14979937 100164 Positive_regulation MMP12 TNF 15987479 103899 Positive_regulation MMP12 TNF 16359550 3105878 Positive_regulation MMP12 TNF 16359550 3105896 Positive_regulation MMP12 TNF 16359550 3105900 Positive_regulation MMP12 TNF 17118171 3096355 Positive_regulation MMP12 TNF 18237379 379288 Positive_regulation MMP12 TNF 19226472 112836 Positive_regulation MMP12 TNF 19281072 1071669 Positive_regulation MMP12 TNF 19435506 113262 Positive_regulation MMP12 TNF 19889233 3097669 Positive_regulation MMP12 TNF 20126546 2439117 Positive_regulation MMP12 TNF 20126546 2439164 Positive_regulation MMP12 TNF 20543948 2452485 Positive_regulation MMP12 TNF 20871770 1047100 Positive_regulation MMP12 TNF 21912722 2223880 Positive_regulation MMP12 TNF 22005011 1697940 Positive_regulation MMP12 TNF 22315682 1687125 Positive_regulation MMP12 TNF 22778767 636637 Positive_regulation MMP12 TNF 23441116 1915730 Positive_regulation MMP12 TNF 23533687 2225600 Positive_regulation MMP12 TNF 23924945 1109776 Positive_regulation MMP12 TNF 24236107 2878536 Positive_regulation MMP12 TNF 24278882 1498597 Positive_regulation MMP12 TNF 24762063 401033 Positive_regulation MMP12 TNF 24926361 844345 Positive_regulation MMP12 TNF 24944589 844735 Positive_regulation MMP12 TNF 24977073 1154300 Positive_regulation MMP12 TNF 25143751 645540 Positive_regulation MMP12 TNF 25147435 1761207 Positive_regulation MMP12 TNF 25250141 1148961 Positive_regulation MMP12 TNF 25356505 1133292 Positive_regulation MMP12 TSPAN1 23840773 2817070 Positive_regulation MMP12 WNT7A 24479426 131497 Positive_regulation MMP13 AGR2 17129374 107097 Positive_regulation MMP13 AGR2 17129374 107098 Positive_regulation MMP13 CAPN8 18493299 2389020 Positive_regulation MMP13 CAPN8 21911754 720116 Positive_regulation MMP13 CCND1 22942717 1097092 Positive_regulation MMP13 EPHB2 18629305 793147 Positive_regulation MMP13 EPHB2 19445683 113358 Positive_regulation MMP13 EPHB2 21246051 2492966 Positive_regulation MMP13 EPHB2 21738525 922801 Positive_regulation MMP13 EPHB2 22310287 2146205 Positive_regulation MMP13 EPHB2 23396374 16973 Positive_regulation MMP13 EPHB2 23663277 1678770 Positive_regulation MMP13 EPHB2 23671446 95549 Positive_regulation MMP13 EPHB2 24069595 184218 Positive_regulation MMP13 EPHB2 24084727 1113090 Positive_regulation MMP13 EPHB2 24084727 1113139 Positive_regulation MMP13 EPHB2 25121739 2997344 Positive_regulation MMP13 F2R 24385683 1756321 Positive_regulation MMP13 F2R 24385683 1756342 Positive_regulation MMP13 F2R 24385683 1756362 Positive_regulation MMP13 F2R 24385683 1756384 Positive_regulation MMP13 GPR115 24066041 2849555 Positive_regulation MMP13 GPR132 24066041 2849544 Positive_regulation MMP13 GPR87 24066041 2849624 Positive_regulation MMP13 HBEGF 21179550 2489201 Positive_regulation MMP13 IL1B 15203568 1739666 Positive_regulation MMP13 IL1B 18031579 109482 Positive_regulation MMP13 IL1B 19011694 2400872 Positive_regulation MMP13 IL1B 19011694 2400883 Positive_regulation MMP13 IL1B 24741591 1621292 Positive_regulation MMP13 MAP2K6 20667128 1857560 Positive_regulation MMP13 MIP 21347304 2503601 Positive_regulation MMP13 MMP28 21787393 229508 Positive_regulation MMP13 MMP28 23028407 2219818 Positive_regulation MMP13 MMP7 21787393 229523 Positive_regulation MMP13 MMP7 23028407 2219833 Positive_regulation MMP13 MUC16 23694968 3135792 Positive_regulation MMP13 PECAM1 12591918 1291189 Positive_regulation MMP13 PGC 25367151 133803 Positive_regulation MMP13 PLAT 23977299 2839909 Positive_regulation MMP13 PLAT 23977299 2839947 Positive_regulation MMP13 PLAT 24303218 2003292 Positive_regulation MMP13 PLAU 24189182 787867 Positive_regulation MMP13 PLAU 9083329 446110 Positive_regulation MMP13 TFPI2 23905012 853450 Positive_regulation MMP13 TFPI2 PMC2756345 496078 Positive_regulation MMP13 TGM2 24130925 204508 Positive_regulation MMP13 TLR7 17129374 107260 Positive_regulation MMP13 TLR7 23940584 2831716 Positive_regulation MMP13 TLR7 PMC4061965 135052 Positive_regulation MMP13 TNF 11237387 418346 Positive_regulation MMP13 TNF 14979937 100165 Positive_regulation MMP13 TNF 15987479 103862 Positive_regulation MMP13 TNF 15987479 103901 Positive_regulation MMP13 TNF 17118171 3096356 Positive_regulation MMP13 TNF 18237379 379289 Positive_regulation MMP13 TNF 19226472 112840 Positive_regulation MMP13 TNF 19281072 1071670 Positive_regulation MMP13 TNF 19296842 112997 Positive_regulation MMP13 TNF 19435506 113263 Positive_regulation MMP13 TNF 19712471 1625623 Positive_regulation MMP13 TNF 19889233 3097670 Positive_regulation MMP13 TNF 20126546 2439118 Positive_regulation MMP13 TNF 20126546 2439165 Positive_regulation MMP13 TNF 20543948 2452487 Positive_regulation MMP13 TNF 20871770 1047101 Positive_regulation MMP13 TNF 21339857 648058 Positive_regulation MMP13 TNF 21912722 2223881 Positive_regulation MMP13 TNF 22005011 1697941 Positive_regulation MMP13 TNF 22315682 1687126 Positive_regulation MMP13 TNF 22605974 1095618 Positive_regulation MMP13 TNF 22778767 636638 Positive_regulation MMP13 TNF 23441116 1915731 Positive_regulation MMP13 TNF 23533687 2225601 Positive_regulation MMP13 TNF 23924945 1109777 Positive_regulation MMP13 TNF 24236107 2878538 Positive_regulation MMP13 TNF 24278882 1498598 Positive_regulation MMP13 TNF 24283517 130114 Positive_regulation MMP13 TNF 24286133 130361 Positive_regulation MMP13 TNF 24458429 691987 Positive_regulation MMP13 TNF 24762063 401034 Positive_regulation MMP13 TNF 24926361 844357 Positive_regulation MMP13 TNF 24977073 1154303 Positive_regulation MMP13 TNF 25143751 645543 Positive_regulation MMP13 TNF 25147435 1761208 Positive_regulation MMP13 TNF 25250141 1148962 Positive_regulation MMP13 TNF 25356505 1133299 Positive_regulation MMP13 TNF 9514050 446960 Positive_regulation MMP13 TSPAN1 23840773 2817092 Positive_regulation MMP13 WNT7A 24479426 131505 Positive_regulation MMP13 WNT7A 24479426 131591 Positive_regulation MMP13 WNT7A 24479426 131670 Positive_regulation MMP14 AGR2 17129374 107101 Positive_regulation MMP14 AGR2 17129374 107102 Positive_regulation MMP14 CAPN8 18493299 2389034 Positive_regulation MMP14 CAPN8 21911754 720131 Positive_regulation MMP14 CAPN8 22407449 86994 Positive_regulation MMP14 CAPN8 22407449 87025 Positive_regulation MMP14 CAPN8 22407449 87119 Positive_regulation MMP14 CAPN8 22407449 87120 Positive_regulation MMP14 CAPN8 22407449 87158 Positive_regulation MMP14 CAPN8 22407449 87176 Positive_regulation MMP14 CAPN8 22407449 87200 Positive_regulation MMP14 CCND1 22942717 1097093 Positive_regulation MMP14 EPHB2 18294404 250790 Positive_regulation MMP14 EPHB2 18629305 793150 Positive_regulation MMP14 EPHB2 19636436 1671454 Positive_regulation MMP14 EPHB2 21738525 922802 Positive_regulation MMP14 EPHB2 22310287 2146206 Positive_regulation MMP14 EPHB2 23663277 1678772 Positive_regulation MMP14 EPHB2 23671446 95563 Positive_regulation MMP14 EPHB2 24084727 1113141 Positive_regulation MMP14 GPR115 24066041 2849648 Positive_regulation MMP14 GPR132 24066041 2849637 Positive_regulation MMP14 GPR87 24066041 2849717 Positive_regulation MMP14 HBEGF 18949075 2208054 Positive_regulation MMP14 HBEGF 21179550 2489203 Positive_regulation MMP14 IL1B 15203568 1739667 Positive_regulation MMP14 KLF9 23812425 2152705 Positive_regulation MMP14 MAP2K6 20667128 1857568 Positive_regulation MMP14 MAP2K6 21371008 451002 Positive_regulation MMP14 MIP 21347304 2503602 Positive_regulation MMP14 MMP28 24511528 186738 Positive_regulation MMP14 MMP7 24511528 186753 Positive_regulation MMP14 MUC16 23694968 3135793 Positive_regulation MMP14 PCSK9 23936445 2830472 Positive_regulation MMP14 PECAM1 12591918 1291190 Positive_regulation MMP14 PLAT 23977299 2839948 Positive_regulation MMP14 PLAT 24303218 2003293 Positive_regulation MMP14 PLAU 24189182 787868 Positive_regulation MMP14 PLAU 9083329 446112 Positive_regulation MMP14 TFPI2 23905012 853451 Positive_regulation MMP14 TFPI2 PMC2756345 496080 Positive_regulation MMP14 TGM2 24130925 204509 Positive_regulation MMP14 TLR7 17129374 107270 Positive_regulation MMP14 TLR7 23940584 2831726 Positive_regulation MMP14 TNF 14979937 100166 Positive_regulation MMP14 TNF 15987479 103903 Positive_regulation MMP14 TNF 17118171 3096357 Positive_regulation MMP14 TNF 18237379 379290 Positive_regulation MMP14 TNF 19226472 112844 Positive_regulation MMP14 TNF 19279689 1909017 Positive_regulation MMP14 TNF 19281072 1071671 Positive_regulation MMP14 TNF 19435506 113265 Positive_regulation MMP14 TNF 19889233 3097671 Positive_regulation MMP14 TNF 20126546 2439119 Positive_regulation MMP14 TNF 20126546 2439166 Positive_regulation MMP14 TNF 20543948 2452489 Positive_regulation MMP14 TNF 20871770 1047102 Positive_regulation MMP14 TNF 21912722 2223882 Positive_regulation MMP14 TNF 22005011 1697942 Positive_regulation MMP14 TNF 22315682 1687127 Positive_regulation MMP14 TNF 22778767 636639 Positive_regulation MMP14 TNF 23441116 1915732 Positive_regulation MMP14 TNF 23533687 2225602 Positive_regulation MMP14 TNF 23924945 1109778 Positive_regulation MMP14 TNF 24213464 499775 Positive_regulation MMP14 TNF 24213464 499776 Positive_regulation MMP14 TNF 24236107 2878540 Positive_regulation MMP14 TNF 24278882 1498599 Positive_regulation MMP14 TNF 24762063 401035 Positive_regulation MMP14 TNF 24926361 844369 Positive_regulation MMP14 TNF 24977073 1154306 Positive_regulation MMP14 TNF 25143751 645546 Positive_regulation MMP14 TNF 25147435 1761209 Positive_regulation MMP14 TNF 25162582 3002804 Positive_regulation MMP14 TNF 25162582 3002885 Positive_regulation MMP14 TNF 25162582 3002917 Positive_regulation MMP14 TNF 25162582 3002919 Positive_regulation MMP14 TNF 25162582 3002931 Positive_regulation MMP14 TNF 25250141 1148963 Positive_regulation MMP14 TNF 25356505 1133306 Positive_regulation MMP14 TNF 25457675 805861 Positive_regulation MMP14 TSPAN1 23840773 2817114 Positive_regulation MMP14 TSPAN1 24549119 503048 Positive_regulation MMP14 WNT7A 24479426 131508 Positive_regulation MMP15 AGR2 17129374 107105 Positive_regulation MMP15 AGR2 17129374 107106 Positive_regulation MMP15 CAPN8 18493299 2389048 Positive_regulation MMP15 CAPN8 21911754 720146 Positive_regulation MMP15 CCND1 22942717 1097094 Positive_regulation MMP15 EPHB2 18629305 793153 Positive_regulation MMP15 EPHB2 21738525 922803 Positive_regulation MMP15 EPHB2 22310287 2146207 Positive_regulation MMP15 EPHB2 23663277 1678774 Positive_regulation MMP15 EPHB2 23671446 95577 Positive_regulation MMP15 EPHB2 24084727 1113143 Positive_regulation MMP15 GPR115 24066041 2849741 Positive_regulation MMP15 GPR132 24066041 2849730 Positive_regulation MMP15 GPR87 24066041 2849810 Positive_regulation MMP15 HBEGF 21179550 2489205 Positive_regulation MMP15 IL1B 15203568 1739668 Positive_regulation MMP15 MAP2K6 20667128 1857576 Positive_regulation MMP15 MIP 21347304 2503603 Positive_regulation MMP15 MUC16 23694968 3135794 Positive_regulation MMP15 PECAM1 12591918 1291191 Positive_regulation MMP15 PLAT 23977299 2839949 Positive_regulation MMP15 PLAT 24303218 2003294 Positive_regulation MMP15 PLAU 24189182 787869 Positive_regulation MMP15 PLAU 9083329 446114 Positive_regulation MMP15 TFPI2 23905012 853452 Positive_regulation MMP15 TFPI2 PMC2756345 496082 Positive_regulation MMP15 TGM2 24130925 204510 Positive_regulation MMP15 TLR7 17129374 107280 Positive_regulation MMP15 TLR7 23940584 2831736 Positive_regulation MMP15 TNF 14979937 100167 Positive_regulation MMP15 TNF 15987479 103905 Positive_regulation MMP15 TNF 17118171 3096358 Positive_regulation MMP15 TNF 18237379 379291 Positive_regulation MMP15 TNF 19226472 112848 Positive_regulation MMP15 TNF 19281072 1071672 Positive_regulation MMP15 TNF 19435506 113266 Positive_regulation MMP15 TNF 19889233 3097672 Positive_regulation MMP15 TNF 20126546 2439120 Positive_regulation MMP15 TNF 20126546 2439167 Positive_regulation MMP15 TNF 20543948 2452491 Positive_regulation MMP15 TNF 20871770 1047103 Positive_regulation MMP15 TNF 21912722 2223883 Positive_regulation MMP15 TNF 22005011 1697943 Positive_regulation MMP15 TNF 22315682 1687128 Positive_regulation MMP15 TNF 22778767 636640 Positive_regulation MMP15 TNF 23441116 1915733 Positive_regulation MMP15 TNF 23533687 2225603 Positive_regulation MMP15 TNF 23924945 1109779 Positive_regulation MMP15 TNF 24236107 2878542 Positive_regulation MMP15 TNF 24278882 1498600 Positive_regulation MMP15 TNF 24762063 401036 Positive_regulation MMP15 TNF 24926361 844381 Positive_regulation MMP15 TNF 24977073 1154309 Positive_regulation MMP15 TNF 25143751 645549 Positive_regulation MMP15 TNF 25147435 1761210 Positive_regulation MMP15 TNF 25250141 1148964 Positive_regulation MMP15 TNF 25356505 1133313 Positive_regulation MMP15 TSPAN1 23840773 2817136 Positive_regulation MMP15 WNT7A 24479426 131510 Positive_regulation MMP16 AGR2 17129374 107109 Positive_regulation MMP16 AGR2 17129374 107110 Positive_regulation MMP16 CAPN8 18493299 2389062 Positive_regulation MMP16 CAPN8 21911754 720161 Positive_regulation MMP16 CCND1 22942717 1097095 Positive_regulation MMP16 EPHB2 18629305 793156 Positive_regulation MMP16 EPHB2 21738525 922804 Positive_regulation MMP16 EPHB2 22310287 2146208 Positive_regulation MMP16 EPHB2 23663277 1678776 Positive_regulation MMP16 EPHB2 23671446 95591 Positive_regulation MMP16 EPHB2 24084727 1113145 Positive_regulation MMP16 GPR115 24066041 2849834 Positive_regulation MMP16 GPR132 24066041 2849823 Positive_regulation MMP16 GPR87 24066041 2849903 Positive_regulation MMP16 HBEGF 21179550 2489207 Positive_regulation MMP16 IL1B 15203568 1739669 Positive_regulation MMP16 MAP2K6 20667128 1857584 Positive_regulation MMP16 MIP 21347304 2503604 Positive_regulation MMP16 MUC16 23694968 3135795 Positive_regulation MMP16 PECAM1 12591918 1291192 Positive_regulation MMP16 PLAT 23977299 2839950 Positive_regulation MMP16 PLAT 24303218 2003295 Positive_regulation MMP16 PLAU 24189182 787870 Positive_regulation MMP16 PLAU 9083329 446116 Positive_regulation MMP16 TFPI2 23905012 853453 Positive_regulation MMP16 TFPI2 PMC2756345 496084 Positive_regulation MMP16 TGM2 24130925 204511 Positive_regulation MMP16 TLR7 17129374 107290 Positive_regulation MMP16 TLR7 23940584 2831746 Positive_regulation MMP16 TNF 11200364 1737600 Positive_regulation MMP16 TNF 14979937 100168 Positive_regulation MMP16 TNF 15987479 103907 Positive_regulation MMP16 TNF 17118171 3096359 Positive_regulation MMP16 TNF 18237379 379292 Positive_regulation MMP16 TNF 19226472 112852 Positive_regulation MMP16 TNF 19281072 1071673 Positive_regulation MMP16 TNF 19435506 113267 Positive_regulation MMP16 TNF 19889233 3097673 Positive_regulation MMP16 TNF 20126546 2439121 Positive_regulation MMP16 TNF 20126546 2439168 Positive_regulation MMP16 TNF 20543948 2452493 Positive_regulation MMP16 TNF 20871770 1047104 Positive_regulation MMP16 TNF 21912722 2223884 Positive_regulation MMP16 TNF 22005011 1697944 Positive_regulation MMP16 TNF 22315682 1687129 Positive_regulation MMP16 TNF 22778767 636641 Positive_regulation MMP16 TNF 23441116 1915734 Positive_regulation MMP16 TNF 23533687 2225604 Positive_regulation MMP16 TNF 23924945 1109780 Positive_regulation MMP16 TNF 24236107 2878544 Positive_regulation MMP16 TNF 24278882 1498601 Positive_regulation MMP16 TNF 24762063 401037 Positive_regulation MMP16 TNF 24926361 844393 Positive_regulation MMP16 TNF 24977073 1154312 Positive_regulation MMP16 TNF 25143751 645552 Positive_regulation MMP16 TNF 25147435 1761211 Positive_regulation MMP16 TNF 25250141 1148965 Positive_regulation MMP16 TNF 25356505 1133320 Positive_regulation MMP16 TSPAN1 23840773 2817158 Positive_regulation MMP16 WNT7A 24479426 131512 Positive_regulation MMP17 AGR2 17129374 107113 Positive_regulation MMP17 AGR2 17129374 107114 Positive_regulation MMP17 CAPN8 18493299 2389076 Positive_regulation MMP17 CAPN8 21911754 720176 Positive_regulation MMP17 CCND1 22942717 1097096 Positive_regulation MMP17 EPHB2 18629305 793159 Positive_regulation MMP17 EPHB2 21738525 922805 Positive_regulation MMP17 EPHB2 22310287 2146209 Positive_regulation MMP17 EPHB2 23663277 1678778 Positive_regulation MMP17 EPHB2 23671446 95605 Positive_regulation MMP17 EPHB2 24084727 1113147 Positive_regulation MMP17 GPR115 24066041 2849927 Positive_regulation MMP17 GPR132 24066041 2849916 Positive_regulation MMP17 GPR87 24066041 2849996 Positive_regulation MMP17 HBEGF 21179550 2489209 Positive_regulation MMP17 IL1B 15203568 1739670 Positive_regulation MMP17 MAP2K6 20667128 1857592 Positive_regulation MMP17 MIP 21347304 2503605 Positive_regulation MMP17 MUC16 23694968 3135796 Positive_regulation MMP17 PECAM1 12591918 1291193 Positive_regulation MMP17 PLAT 23977299 2839951 Positive_regulation MMP17 PLAT 24303218 2003296 Positive_regulation MMP17 PLAU 24189182 787871 Positive_regulation MMP17 PLAU 9083329 446118 Positive_regulation MMP17 TFPI2 23905012 853454 Positive_regulation MMP17 TFPI2 PMC2756345 496086 Positive_regulation MMP17 TGM2 24130925 204512 Positive_regulation MMP17 TLR7 17129374 107300 Positive_regulation MMP17 TLR7 23940584 2831756 Positive_regulation MMP17 TNF 14979937 100169 Positive_regulation MMP17 TNF 15987479 103909 Positive_regulation MMP17 TNF 17118171 3096360 Positive_regulation MMP17 TNF 18237379 379293 Positive_regulation MMP17 TNF 19226472 112856 Positive_regulation MMP17 TNF 19281072 1071674 Positive_regulation MMP17 TNF 19435506 113268 Positive_regulation MMP17 TNF 19889233 3097674 Positive_regulation MMP17 TNF 20126546 2439122 Positive_regulation MMP17 TNF 20126546 2439169 Positive_regulation MMP17 TNF 20543948 2452495 Positive_regulation MMP17 TNF 20871770 1047105 Positive_regulation MMP17 TNF 21912722 2223885 Positive_regulation MMP17 TNF 22005011 1697945 Positive_regulation MMP17 TNF 22315682 1687130 Positive_regulation MMP17 TNF 22778767 636642 Positive_regulation MMP17 TNF 23441116 1915735 Positive_regulation MMP17 TNF 23533687 2225605 Positive_regulation MMP17 TNF 23924945 1109781 Positive_regulation MMP17 TNF 24236107 2878546 Positive_regulation MMP17 TNF 24278882 1498602 Positive_regulation MMP17 TNF 24762063 401038 Positive_regulation MMP17 TNF 24926361 844405 Positive_regulation MMP17 TNF 24977073 1154315 Positive_regulation MMP17 TNF 25143751 645555 Positive_regulation MMP17 TNF 25147435 1761212 Positive_regulation MMP17 TNF 25250141 1148966 Positive_regulation MMP17 TNF 25356505 1133327 Positive_regulation MMP17 TSPAN1 23840773 2817180 Positive_regulation MMP17 WNT7A 24479426 131514 Positive_regulation MMP19 AGR2 17129374 107117 Positive_regulation MMP19 AGR2 17129374 107118 Positive_regulation MMP19 CAPN8 18493299 2389090 Positive_regulation MMP19 CAPN8 21911754 720191 Positive_regulation MMP19 CCND1 22942717 1097097 Positive_regulation MMP19 EPHB2 18629305 793162 Positive_regulation MMP19 EPHB2 21738525 922806 Positive_regulation MMP19 EPHB2 22310287 2146210 Positive_regulation MMP19 EPHB2 23663277 1678780 Positive_regulation MMP19 EPHB2 23671446 95619 Positive_regulation MMP19 EPHB2 24084727 1113149 Positive_regulation MMP19 GPR115 24066041 2850020 Positive_regulation MMP19 GPR132 24066041 2850009 Positive_regulation MMP19 GPR87 24066041 2850089 Positive_regulation MMP19 HBEGF 21179550 2489211 Positive_regulation MMP19 IL1B 15203568 1739671 Positive_regulation MMP19 MAP2K6 20667128 1857600 Positive_regulation MMP19 MIP 21347304 2503606 Positive_regulation MMP19 MUC16 23694968 3135797 Positive_regulation MMP19 PECAM1 12591918 1291194 Positive_regulation MMP19 PLAT 23977299 2839952 Positive_regulation MMP19 PLAT 24303218 2003297 Positive_regulation MMP19 PLAU 24189182 787872 Positive_regulation MMP19 PLAU 9083329 446120 Positive_regulation MMP19 TFPI2 23905012 853455 Positive_regulation MMP19 TFPI2 PMC2756345 496088 Positive_regulation MMP19 TGM2 24130925 204513 Positive_regulation MMP19 TLR7 17129374 107310 Positive_regulation MMP19 TLR7 23940584 2831766 Positive_regulation MMP19 TNF 14979937 100170 Positive_regulation MMP19 TNF 15987479 103911 Positive_regulation MMP19 TNF 17118171 3096361 Positive_regulation MMP19 TNF 18237379 379294 Positive_regulation MMP19 TNF 19226472 112860 Positive_regulation MMP19 TNF 19281072 1071675 Positive_regulation MMP19 TNF 19435506 113269 Positive_regulation MMP19 TNF 19889233 3097675 Positive_regulation MMP19 TNF 20126546 2439123 Positive_regulation MMP19 TNF 20126546 2439170 Positive_regulation MMP19 TNF 20543948 2452497 Positive_regulation MMP19 TNF 20871770 1047106 Positive_regulation MMP19 TNF 21067565 397469 Positive_regulation MMP19 TNF 21912722 2223886 Positive_regulation MMP19 TNF 22005011 1697946 Positive_regulation MMP19 TNF 22315682 1687131 Positive_regulation MMP19 TNF 22778767 636643 Positive_regulation MMP19 TNF 23441116 1915736 Positive_regulation MMP19 TNF 23533687 2225606 Positive_regulation MMP19 TNF 23924945 1109782 Positive_regulation MMP19 TNF 24236107 2878548 Positive_regulation MMP19 TNF 24278882 1498603 Positive_regulation MMP19 TNF 24762063 401039 Positive_regulation MMP19 TNF 24926361 844417 Positive_regulation MMP19 TNF 24977073 1154318 Positive_regulation MMP19 TNF 25143751 645558 Positive_regulation MMP19 TNF 25147435 1761213 Positive_regulation MMP19 TNF 25250141 1148967 Positive_regulation MMP19 TNF 25356505 1133334 Positive_regulation MMP19 TSPAN1 23840773 2817202 Positive_regulation MMP19 WNT7A 24479426 131516 Positive_regulation MMP2 ADAMTS1 19116037 3096832 Positive_regulation MMP2 AGR2 17129374 107121 Positive_regulation MMP2 AGR2 17129374 107122 Positive_regulation MMP2 AXIN2 24454854 2910167 Positive_regulation MMP2 CAPN8 18493299 2389104 Positive_regulation MMP2 CAPN8 21911754 720206 Positive_regulation MMP2 CAPN8 21911754 720367 Positive_regulation MMP2 CCND1 22942717 1097098 Positive_regulation MMP2 CLU 22949882 1098129 Positive_regulation MMP2 CLU 22949882 1098139 Positive_regulation MMP2 CTGF 21304949 2501836 Positive_regulation MMP2 CTGF 22212430 14246 Positive_regulation MMP2 CTGF 24015193 2842200 Positive_regulation MMP2 CTGF 25003330 2195009 Positive_regulation MMP2 EPHB2 12865932 422937 Positive_regulation MMP2 EPHB2 18294404 250791 Positive_regulation MMP2 EPHB2 18629305 793165 Positive_regulation MMP2 EPHB2 19292920 1722802 Positive_regulation MMP2 EPHB2 20214814 255476 Positive_regulation MMP2 EPHB2 21569377 1658337 Positive_regulation MMP2 EPHB2 21738525 922807 Positive_regulation MMP2 EPHB2 22310287 2146211 Positive_regulation MMP2 EPHB2 22506069 2618352 Positive_regulation MMP2 EPHB2 23663277 1678782 Positive_regulation MMP2 EPHB2 23671446 95633 Positive_regulation MMP2 EPHB2 23911909 1637828 Positive_regulation MMP2 EPHB2 23911909 1637866 Positive_regulation MMP2 EPHB2 24084727 1113151 Positive_regulation MMP2 EPHB2 24278338 2885774 Positive_regulation MMP2 EPHB2 24278338 2885778 Positive_regulation MMP2 EPHB2 24318272 2186023 Positive_regulation MMP2 EPHB2 25050378 195310 Positive_regulation MMP2 EPHB2 25203554 3006399 Positive_regulation MMP2 FAS 21573233 2522996 Positive_regulation MMP2 GPR115 24066041 2850113 Positive_regulation MMP2 GPR132 24066041 2850102 Positive_regulation MMP2 GPR87 24066041 2850182 Positive_regulation MMP2 HBEGF 21179550 2489213 Positive_regulation MMP2 ID1 23714001 1699824 Positive_regulation MMP2 ID1 23714001 1699828 Positive_regulation MMP2 ID1 23714001 1699833 Positive_regulation MMP2 ID1 23714001 1699837 Positive_regulation MMP2 IL1B 15203568 1739672 Positive_regulation MMP2 MAP2K6 20667128 1857608 Positive_regulation MMP2 MAP2K6 22310287 2146230 Positive_regulation MMP2 MAP2K6 24013225 2153519 Positive_regulation MMP2 MAP2K6 24318272 2186029 Positive_regulation MMP2 MIP 21347304 2503607 Positive_regulation MMP2 MMP28 11384099 418806 Positive_regulation MMP2 MMP28 11401321 419037 Positive_regulation MMP2 MMP28 11437402 419070 Positive_regulation MMP2 MMP28 15197174 1309453 Positive_regulation MMP2 MMP28 20067755 2222073 Positive_regulation MMP2 MMP28 20856827 1071774 Positive_regulation MMP2 MMP28 21118526 2111610 Positive_regulation MMP2 MMP28 21687519 950326 Positive_regulation MMP2 MMP28 23388158 521789 Positive_regulation MMP2 MMP28 23565108 935302 Positive_regulation MMP2 MMP28 24199964 1481823 Positive_regulation MMP2 MMP28 24231999 1137944 Positive_regulation MMP2 MMP28 24324615 2890792 Positive_regulation MMP2 MMP28 24511528 186760 Positive_regulation MMP2 MMP28 24806521 2962441 Positive_regulation MMP2 MMP28 PMC2062791 448298 Positive_regulation MMP2 MMP7 11384099 418821 Positive_regulation MMP2 MMP7 11401321 419052 Positive_regulation MMP2 MMP7 11437402 419085 Positive_regulation MMP2 MMP7 15197174 1309468 Positive_regulation MMP2 MMP7 20067755 2222088 Positive_regulation MMP2 MMP7 20856827 1071789 Positive_regulation MMP2 MMP7 21118526 2111625 Positive_regulation MMP2 MMP7 21687519 950342 Positive_regulation MMP2 MMP7 21829768 1636413 Positive_regulation MMP2 MMP7 22400063 3177210 Positive_regulation MMP2 MMP7 23388158 521804 Positive_regulation MMP2 MMP7 23565108 935317 Positive_regulation MMP2 MMP7 24199964 1481838 Positive_regulation MMP2 MMP7 24231999 1137959 Positive_regulation MMP2 MMP7 24324615 2890807 Positive_regulation MMP2 MMP7 24511528 186775 Positive_regulation MMP2 MMP7 24806521 2962456 Positive_regulation MMP2 MMP7 PMC2062791 448313 Positive_regulation MMP2 MUC16 23694968 3135798 Positive_regulation MMP2 MUC16 23694968 3136014 Positive_regulation MMP2 NNMT 22545051 1673659 Positive_regulation MMP2 NNMT 22545051 1673660 Positive_regulation MMP2 NNMT 22545051 1673662 Positive_regulation MMP2 NNMT 22545051 1673664 Positive_regulation MMP2 NNMT 23764850 562403 Positive_regulation MMP2 PECAM1 12591918 1291195 Positive_regulation MMP2 PLAT 21679435 845879 Positive_regulation MMP2 PLAT 21799677 812958 Positive_regulation MMP2 PLAT 23977299 2839953 Positive_regulation MMP2 PLAT 24303218 2003298 Positive_regulation MMP2 PLAU 12865932 422938 Positive_regulation MMP2 PLAU 21799677 812959 Positive_regulation MMP2 PLAU 24098421 2856293 Positive_regulation MMP2 PLAU 24189182 787873 Positive_regulation MMP2 PLAU 24709902 617316 Positive_regulation MMP2 PLAU 25170871 3004004 Positive_regulation MMP2 PLAU 25222667 1730975 Positive_regulation MMP2 PLAU 9083329 446122 Positive_regulation MMP2 SLC38A3 PMC2364207 449969 Positive_regulation MMP2 TFPI2 17717633 493681 Positive_regulation MMP2 TFPI2 23905012 853456 Positive_regulation MMP2 TFPI2 PMC2756345 496090 Positive_regulation MMP2 TGM2 21359202 2504099 Positive_regulation MMP2 TGM2 24130925 204475 Positive_regulation MMP2 TGM2 24130925 204476 Positive_regulation MMP2 TGM2 24130925 204477 Positive_regulation MMP2 TGM2 24130925 204485 Positive_regulation MMP2 TGM2 24130925 204489 Positive_regulation MMP2 TGM2 24130925 204493 Positive_regulation MMP2 TGM2 24130925 204494 Positive_regulation MMP2 TGM2 24130925 204514 Positive_regulation MMP2 TLR7 17129374 107320 Positive_regulation MMP2 TLR7 23940584 2831776 Positive_regulation MMP2 TNF 12516548 2001312 Positive_regulation MMP2 TNF 12966436 423291 Positive_regulation MMP2 TNF 14979937 100116 Positive_regulation MMP2 TNF 14979937 100171 Positive_regulation MMP2 TNF 15987479 103913 Positive_regulation MMP2 TNF 16106101 1740042 Positive_regulation MMP2 TNF 16106101 1740043 Positive_regulation MMP2 TNF 17118171 3096362 Positive_regulation MMP2 TNF 18001502 109447 Positive_regulation MMP2 TNF 18237379 379295 Positive_regulation MMP2 TNF 19226472 112864 Positive_regulation MMP2 TNF 19281072 1071676 Positive_regulation MMP2 TNF 19298660 352658 Positive_regulation MMP2 TNF 19435506 113270 Positive_regulation MMP2 TNF 19889233 3097676 Positive_regulation MMP2 TNF 20126546 2439124 Positive_regulation MMP2 TNF 20126546 2439171 Positive_regulation MMP2 TNF 20368952 2114525 Positive_regulation MMP2 TNF 20543948 2452499 Positive_regulation MMP2 TNF 20871770 1047107 Positive_regulation MMP2 TNF 21569331 1229089 Positive_regulation MMP2 TNF 21867555 1659594 Positive_regulation MMP2 TNF 21867555 1659595 Positive_regulation MMP2 TNF 21912722 2223887 Positive_regulation MMP2 TNF 22005011 1697947 Positive_regulation MMP2 TNF 22315682 1687132 Positive_regulation MMP2 TNF 22778767 636644 Positive_regulation MMP2 TNF 22899878 1750208 Positive_regulation MMP2 TNF 23437179 2755926 Positive_regulation MMP2 TNF 23441116 1915737 Positive_regulation MMP2 TNF 23533687 2225607 Positive_regulation MMP2 TNF 23840095 1753415 Positive_regulation MMP2 TNF 23864892 821534 Positive_regulation MMP2 TNF 23924945 1109783 Positive_regulation MMP2 TNF 24085323 1142194 Positive_regulation MMP2 TNF 24085323 1142195 Positive_regulation MMP2 TNF 24085323 1142196 Positive_regulation MMP2 TNF 24085323 1142227 Positive_regulation MMP2 TNF 24190483 1142422 Positive_regulation MMP2 TNF 24223987 2877538 Positive_regulation MMP2 TNF 24236107 2878550 Positive_regulation MMP2 TNF 24278882 1498604 Positive_regulation MMP2 TNF 24289089 131077 Positive_regulation MMP2 TNF 24502696 1233178 Positive_regulation MMP2 TNF 24552146 295820 Positive_regulation MMP2 TNF 24762063 401040 Positive_regulation MMP2 TNF 24926361 844219 Positive_regulation MMP2 TNF 24926361 844220 Positive_regulation MMP2 TNF 24926361 844221 Positive_regulation MMP2 TNF 24926361 844222 Positive_regulation MMP2 TNF 24926361 844223 Positive_regulation MMP2 TNF 24926361 844224 Positive_regulation MMP2 TNF 24926361 844225 Positive_regulation MMP2 TNF 24926361 844226 Positive_regulation MMP2 TNF 24926361 844227 Positive_regulation MMP2 TNF 24926361 844228 Positive_regulation MMP2 TNF 24926361 844229 Positive_regulation MMP2 TNF 24926361 844429 Positive_regulation MMP2 TNF 24926361 844538 Positive_regulation MMP2 TNF 24977073 1154321 Positive_regulation MMP2 TNF 25143751 645561 Positive_regulation MMP2 TNF 25147435 1761214 Positive_regulation MMP2 TNF 25250141 1148968 Positive_regulation MMP2 TNF 25356505 1133341 Positive_regulation MMP2 TNF 25594007 2173579 Positive_regulation MMP2 TNF PMC4288337 1623782 Positive_regulation MMP2 TSPAN1 10491398 1249656 Positive_regulation MMP2 TSPAN1 10491398 1249657 Positive_regulation MMP2 TSPAN1 10491398 1250802 Positive_regulation MMP2 TSPAN1 10491398 1250824 Positive_regulation MMP2 TSPAN1 10491398 1250848 Positive_regulation MMP2 TSPAN1 15762987 318287 Positive_regulation MMP2 TSPAN1 23840773 2817224 Positive_regulation MMP2 WIF1 20573255 1856525 Positive_regulation MMP2 WNT7A 24479426 131518 Positive_regulation MMP20 AGR2 17129374 107125 Positive_regulation MMP20 AGR2 17129374 107126 Positive_regulation MMP20 CAPN8 18493299 2389120 Positive_regulation MMP20 CAPN8 21911754 720221 Positive_regulation MMP20 CCND1 22942717 1097099 Positive_regulation MMP20 EPHB2 18629305 793168 Positive_regulation MMP20 EPHB2 21738525 922808 Positive_regulation MMP20 EPHB2 22310287 2146212 Positive_regulation MMP20 EPHB2 23663277 1678784 Positive_regulation MMP20 EPHB2 23671446 95647 Positive_regulation MMP20 EPHB2 24084727 1113153 Positive_regulation MMP20 GPR115 24066041 2850206 Positive_regulation MMP20 GPR132 24066041 2850195 Positive_regulation MMP20 GPR87 24066041 2850275 Positive_regulation MMP20 HBEGF 21179550 2489215 Positive_regulation MMP20 IL1B 15203568 1739673 Positive_regulation MMP20 MAP2K6 20667128 1857616 Positive_regulation MMP20 MIP 21347304 2503608 Positive_regulation MMP20 MUC16 23694968 3135799 Positive_regulation MMP20 PECAM1 12591918 1291196 Positive_regulation MMP20 PLAT 23977299 2839954 Positive_regulation MMP20 PLAT 24303218 2003299 Positive_regulation MMP20 PLAU 24189182 787874 Positive_regulation MMP20 PLAU 9083329 446124 Positive_regulation MMP20 TFPI2 23905012 853457 Positive_regulation MMP20 TFPI2 PMC2756345 496092 Positive_regulation MMP20 TGM2 24130925 204515 Positive_regulation MMP20 TLR7 17129374 107330 Positive_regulation MMP20 TLR7 23940584 2831786 Positive_regulation MMP20 TNF 14979937 100172 Positive_regulation MMP20 TNF 15987479 103915 Positive_regulation MMP20 TNF 17118171 3096363 Positive_regulation MMP20 TNF 18237379 379296 Positive_regulation MMP20 TNF 19226472 112868 Positive_regulation MMP20 TNF 19281072 1071677 Positive_regulation MMP20 TNF 19435506 113271 Positive_regulation MMP20 TNF 19889233 3097677 Positive_regulation MMP20 TNF 20126546 2439125 Positive_regulation MMP20 TNF 20126546 2439172 Positive_regulation MMP20 TNF 20543948 2452501 Positive_regulation MMP20 TNF 20871770 1047108 Positive_regulation MMP20 TNF 21912722 2223888 Positive_regulation MMP20 TNF 22005011 1697948 Positive_regulation MMP20 TNF 22315682 1687133 Positive_regulation MMP20 TNF 22778767 636645 Positive_regulation MMP20 TNF 23441116 1915738 Positive_regulation MMP20 TNF 23533687 2225608 Positive_regulation MMP20 TNF 23924945 1109784 Positive_regulation MMP20 TNF 24236107 2878552 Positive_regulation MMP20 TNF 24278882 1498605 Positive_regulation MMP20 TNF 24762063 401041 Positive_regulation MMP20 TNF 24926361 844441 Positive_regulation MMP20 TNF 24977073 1154324 Positive_regulation MMP20 TNF 25143751 645564 Positive_regulation MMP20 TNF 25147435 1761215 Positive_regulation MMP20 TNF 25250141 1148969 Positive_regulation MMP20 TNF 25356505 1133353 Positive_regulation MMP20 TSPAN1 23840773 2817246 Positive_regulation MMP20 WNT7A 24479426 131520 Positive_regulation MMP21 ABCA4 23805043 1915996 Positive_regulation MMP21 AGR2 17129374 107073 Positive_regulation MMP21 AGR2 17129374 107074 Positive_regulation MMP21 CAPN8 18493299 2388906 Positive_regulation MMP21 CAPN8 21911754 720026 Positive_regulation MMP21 CCND1 22942717 1097086 Positive_regulation MMP21 EPHB2 18629305 793063 Positive_regulation MMP21 EPHB2 21738525 922795 Positive_regulation MMP21 EPHB2 22310287 2146199 Positive_regulation MMP21 EPHB2 23663277 1678758 Positive_regulation MMP21 EPHB2 23671446 95465 Positive_regulation MMP21 EPHB2 24084727 1113127 Positive_regulation MMP21 GPR115 24066041 2848997 Positive_regulation MMP21 GPR132 24066041 2848986 Positive_regulation MMP21 GPR87 24066041 2849066 Positive_regulation MMP21 HBEGF 21179550 2489057 Positive_regulation MMP21 IL1B 15203568 1739659 Positive_regulation MMP21 MAP2K6 20667128 1857512 Positive_regulation MMP21 MIP 21347304 2503595 Positive_regulation MMP21 MUC16 23694968 3135778 Positive_regulation MMP21 PECAM1 12591918 1291183 Positive_regulation MMP21 PLAT 23977299 2839941 Positive_regulation MMP21 PLAT 24303218 2003286 Positive_regulation MMP21 PLAU 24189182 787861 Positive_regulation MMP21 PLAU 9083329 446098 Positive_regulation MMP21 TFPI2 23905012 853444 Positive_regulation MMP21 TFPI2 PMC2756345 496054 Positive_regulation MMP21 TGM2 24130925 204502 Positive_regulation MMP21 TLR7 17129374 107200 Positive_regulation MMP21 TLR7 23940584 2831656 Positive_regulation MMP21 TNF 14979937 100159 Positive_regulation MMP21 TNF 15987479 103889 Positive_regulation MMP21 TNF 17118171 3096350 Positive_regulation MMP21 TNF 18237379 379283 Positive_regulation MMP21 TNF 19226472 112810 Positive_regulation MMP21 TNF 19281072 1071663 Positive_regulation MMP21 TNF 19435506 113256 Positive_regulation MMP21 TNF 19889233 3097664 Positive_regulation MMP21 TNF 20126546 2439112 Positive_regulation MMP21 TNF 20126546 2439159 Positive_regulation MMP21 TNF 20543948 2452475 Positive_regulation MMP21 TNF 20871770 1047095 Positive_regulation MMP21 TNF 21912722 2223875 Positive_regulation MMP21 TNF 22005011 1697935 Positive_regulation MMP21 TNF 22315682 1687074 Positive_regulation MMP21 TNF 22778767 636632 Positive_regulation MMP21 TNF 23441116 1915725 Positive_regulation MMP21 TNF 23533687 2225595 Positive_regulation MMP21 TNF 23924945 1109769 Positive_regulation MMP21 TNF 24236107 2878526 Positive_regulation MMP21 TNF 24278882 1498592 Positive_regulation MMP21 TNF 24762063 401028 Positive_regulation MMP21 TNF 24926361 844282 Positive_regulation MMP21 TNF 24977073 1154282 Positive_regulation MMP21 TNF 25143751 645525 Positive_regulation MMP21 TNF 25147435 1761202 Positive_regulation MMP21 TNF 25250141 1148956 Positive_regulation MMP21 TNF 25356505 1132721 Positive_regulation MMP21 TSPAN1 23840773 2816960 Positive_regulation MMP21 WNT7A 24479426 131481 Positive_regulation MMP24 AGR2 17129374 107129 Positive_regulation MMP24 AGR2 17129374 107130 Positive_regulation MMP24 CAPN8 18493299 2389134 Positive_regulation MMP24 CAPN8 21911754 720236 Positive_regulation MMP24 CCND1 22942717 1097100 Positive_regulation MMP24 EPHB2 18629305 793171 Positive_regulation MMP24 EPHB2 21738525 922809 Positive_regulation MMP24 EPHB2 22310287 2146213 Positive_regulation MMP24 EPHB2 23663277 1678786 Positive_regulation MMP24 EPHB2 23671446 95661 Positive_regulation MMP24 EPHB2 24084727 1113155 Positive_regulation MMP24 GPR115 24066041 2850299 Positive_regulation MMP24 GPR132 24066041 2850288 Positive_regulation MMP24 GPR87 24066041 2850368 Positive_regulation MMP24 HBEGF 21179550 2489217 Positive_regulation MMP24 IL1B 15203568 1739674 Positive_regulation MMP24 MAP2K6 20667128 1857624 Positive_regulation MMP24 MIP 21347304 2503609 Positive_regulation MMP24 MUC16 23694968 3135800 Positive_regulation MMP24 PECAM1 12591918 1291197 Positive_regulation MMP24 PLAT 23977299 2839955 Positive_regulation MMP24 PLAT 24303218 2003300 Positive_regulation MMP24 PLAU 24189182 787875 Positive_regulation MMP24 PLAU 9083329 446126 Positive_regulation MMP24 TFPI2 23905012 853458 Positive_regulation MMP24 TFPI2 PMC2756345 496094 Positive_regulation MMP24 TGM2 24130925 204516 Positive_regulation MMP24 TLR7 17129374 107340 Positive_regulation MMP24 TLR7 23940584 2831796 Positive_regulation MMP24 TNF 14979937 100173 Positive_regulation MMP24 TNF 15987479 103917 Positive_regulation MMP24 TNF 17118171 3096364 Positive_regulation MMP24 TNF 18237379 379297 Positive_regulation MMP24 TNF 19226472 112872 Positive_regulation MMP24 TNF 19281072 1071678 Positive_regulation MMP24 TNF 19435506 113272 Positive_regulation MMP24 TNF 19889233 3097678 Positive_regulation MMP24 TNF 20126546 2439126 Positive_regulation MMP24 TNF 20126546 2439173 Positive_regulation MMP24 TNF 20543948 2452503 Positive_regulation MMP24 TNF 20871770 1047109 Positive_regulation MMP24 TNF 21912722 2223889 Positive_regulation MMP24 TNF 22005011 1697949 Positive_regulation MMP24 TNF 22315682 1687134 Positive_regulation MMP24 TNF 22778767 636646 Positive_regulation MMP24 TNF 23441116 1915739 Positive_regulation MMP24 TNF 23533687 2225609 Positive_regulation MMP24 TNF 23924945 1109785 Positive_regulation MMP24 TNF 24236107 2878554 Positive_regulation MMP24 TNF 24278882 1498606 Positive_regulation MMP24 TNF 24762063 401042 Positive_regulation MMP24 TNF 24926361 844453 Positive_regulation MMP24 TNF 24977073 1154327 Positive_regulation MMP24 TNF 25143751 645567 Positive_regulation MMP24 TNF 25147435 1761216 Positive_regulation MMP24 TNF 25250141 1148970 Positive_regulation MMP24 TNF 25356505 1133360 Positive_regulation MMP24 TSPAN1 23840773 2817268 Positive_regulation MMP24 WNT7A 24479426 131522 Positive_regulation MMP25 AGR2 17129374 107061 Positive_regulation MMP25 AGR2 17129374 107062 Positive_regulation MMP25 CAPN8 18493299 2388864 Positive_regulation MMP25 CAPN8 21911754 719981 Positive_regulation MMP25 CCND1 22942717 1097083 Positive_regulation MMP25 EPHB2 18629305 793054 Positive_regulation MMP25 EPHB2 21738525 922792 Positive_regulation MMP25 EPHB2 22310287 2146196 Positive_regulation MMP25 EPHB2 23663277 1678752 Positive_regulation MMP25 EPHB2 23671446 95423 Positive_regulation MMP25 EPHB2 24084727 1113121 Positive_regulation MMP25 GPR115 24066041 2848718 Positive_regulation MMP25 GPR132 24066041 2848707 Positive_regulation MMP25 GPR87 24066041 2848787 Positive_regulation MMP25 HBEGF 21179550 2489051 Positive_regulation MMP25 IL1B 15203568 1739656 Positive_regulation MMP25 MAP2K6 20667128 1857488 Positive_regulation MMP25 MIP 21347304 2503592 Positive_regulation MMP25 MUC16 23694968 3135775 Positive_regulation MMP25 PECAM1 12591918 1291180 Positive_regulation MMP25 PLAT 23977299 2839938 Positive_regulation MMP25 PLAT 24303218 2003283 Positive_regulation MMP25 PLAU 24189182 787858 Positive_regulation MMP25 PLAU 9083329 446092 Positive_regulation MMP25 TFPI2 23905012 853441 Positive_regulation MMP25 TFPI2 PMC2756345 496048 Positive_regulation MMP25 TGM2 24130925 204499 Positive_regulation MMP25 TLR7 17129374 107170 Positive_regulation MMP25 TLR7 23940584 2831626 Positive_regulation MMP25 TNF 14979937 100156 Positive_regulation MMP25 TNF 15987479 103883 Positive_regulation MMP25 TNF 17118171 3096347 Positive_regulation MMP25 TNF 18237379 379280 Positive_regulation MMP25 TNF 19226472 112798 Positive_regulation MMP25 TNF 19281072 1071660 Positive_regulation MMP25 TNF 19435506 113253 Positive_regulation MMP25 TNF 19889233 3097661 Positive_regulation MMP25 TNF 20126546 2439109 Positive_regulation MMP25 TNF 20126546 2439156 Positive_regulation MMP25 TNF 20543948 2452469 Positive_regulation MMP25 TNF 20871770 1047092 Positive_regulation MMP25 TNF 21912722 2223872 Positive_regulation MMP25 TNF 22005011 1697932 Positive_regulation MMP25 TNF 22315682 1687071 Positive_regulation MMP25 TNF 22778767 636629 Positive_regulation MMP25 TNF 23441116 1915722 Positive_regulation MMP25 TNF 23533687 2225592 Positive_regulation MMP25 TNF 23924945 1109766 Positive_regulation MMP25 TNF 24236107 2878520 Positive_regulation MMP25 TNF 24278882 1498589 Positive_regulation MMP25 TNF 24762063 401025 Positive_regulation MMP25 TNF 24926361 844246 Positive_regulation MMP25 TNF 24977073 1154273 Positive_regulation MMP25 TNF 25143751 645516 Positive_regulation MMP25 TNF 25147435 1761199 Positive_regulation MMP25 TNF 25250141 1148953 Positive_regulation MMP25 TNF 25356505 1132701 Positive_regulation MMP25 TSPAN1 23840773 2816894 Positive_regulation MMP25 WNT7A 24479426 131475 Positive_regulation MMP26 AGR2 17129374 107065 Positive_regulation MMP26 AGR2 17129374 107066 Positive_regulation MMP26 CAPN8 18493299 2388878 Positive_regulation MMP26 CAPN8 21911754 719996 Positive_regulation MMP26 CCND1 22942717 1097084 Positive_regulation MMP26 EPHB2 18629305 793057 Positive_regulation MMP26 EPHB2 21738525 922793 Positive_regulation MMP26 EPHB2 22310287 2146197 Positive_regulation MMP26 EPHB2 23663277 1678754 Positive_regulation MMP26 EPHB2 23671446 95437 Positive_regulation MMP26 EPHB2 24084727 1113123 Positive_regulation MMP26 GPR115 24066041 2848811 Positive_regulation MMP26 GPR132 24066041 2848800 Positive_regulation MMP26 GPR87 24066041 2848880 Positive_regulation MMP26 HBEGF 21179550 2489053 Positive_regulation MMP26 IL1B 15203568 1739657 Positive_regulation MMP26 MAP2K6 20667128 1857496 Positive_regulation MMP26 MIP 21347304 2503593 Positive_regulation MMP26 MUC16 23694968 3135776 Positive_regulation MMP26 PECAM1 12591918 1291181 Positive_regulation MMP26 PLAT 23977299 2839939 Positive_regulation MMP26 PLAT 24303218 2003284 Positive_regulation MMP26 PLAU 24189182 787859 Positive_regulation MMP26 PLAU 9083329 446094 Positive_regulation MMP26 TFPI2 23905012 853442 Positive_regulation MMP26 TFPI2 PMC2756345 496050 Positive_regulation MMP26 TGM2 24130925 204500 Positive_regulation MMP26 TLR7 17129374 107180 Positive_regulation MMP26 TLR7 23940584 2831636 Positive_regulation MMP26 TNF 14979937 100157 Positive_regulation MMP26 TNF 15987479 103885 Positive_regulation MMP26 TNF 17118171 3096348 Positive_regulation MMP26 TNF 18237379 379281 Positive_regulation MMP26 TNF 19226472 112802 Positive_regulation MMP26 TNF 19281072 1071661 Positive_regulation MMP26 TNF 19435506 113254 Positive_regulation MMP26 TNF 19889233 3097662 Positive_regulation MMP26 TNF 20126546 2439110 Positive_regulation MMP26 TNF 20126546 2439157 Positive_regulation MMP26 TNF 20543948 2452471 Positive_regulation MMP26 TNF 20871770 1047093 Positive_regulation MMP26 TNF 21912722 2223873 Positive_regulation MMP26 TNF 22005011 1697933 Positive_regulation MMP26 TNF 22315682 1687072 Positive_regulation MMP26 TNF 22778767 636630 Positive_regulation MMP26 TNF 23441116 1915723 Positive_regulation MMP26 TNF 23533687 2225593 Positive_regulation MMP26 TNF 23924945 1109767 Positive_regulation MMP26 TNF 24236107 2878522 Positive_regulation MMP26 TNF 24278882 1498590 Positive_regulation MMP26 TNF 24762063 401026 Positive_regulation MMP26 TNF 24926361 844258 Positive_regulation MMP26 TNF 24977073 1154276 Positive_regulation MMP26 TNF 25143751 645519 Positive_regulation MMP26 TNF 25147435 1761200 Positive_regulation MMP26 TNF 25250141 1148954 Positive_regulation MMP26 TNF 25356505 1132707 Positive_regulation MMP26 TSPAN1 23840773 2816916 Positive_regulation MMP26 WNT7A 24479426 131477 Positive_regulation MMP27 AGR2 17129374 107069 Positive_regulation MMP27 AGR2 17129374 107070 Positive_regulation MMP27 CAPN8 18493299 2388892 Positive_regulation MMP27 CAPN8 21911754 720011 Positive_regulation MMP27 CCND1 22942717 1097085 Positive_regulation MMP27 EPHB2 18629305 793060 Positive_regulation MMP27 EPHB2 21738525 922794 Positive_regulation MMP27 EPHB2 22310287 2146198 Positive_regulation MMP27 EPHB2 23663277 1678756 Positive_regulation MMP27 EPHB2 23671446 95451 Positive_regulation MMP27 EPHB2 24084727 1113125 Positive_regulation MMP27 GPR115 24066041 2848904 Positive_regulation MMP27 GPR132 24066041 2848893 Positive_regulation MMP27 GPR87 24066041 2848973 Positive_regulation MMP27 HBEGF 21179550 2489055 Positive_regulation MMP27 IL1B 15203568 1739658 Positive_regulation MMP27 MAP2K6 20667128 1857504 Positive_regulation MMP27 MIP 21347304 2503594 Positive_regulation MMP27 MUC16 23694968 3135777 Positive_regulation MMP27 PECAM1 12591918 1291182 Positive_regulation MMP27 PLAT 23977299 2839940 Positive_regulation MMP27 PLAT 24303218 2003285 Positive_regulation MMP27 PLAU 24189182 787860 Positive_regulation MMP27 PLAU 9083329 446096 Positive_regulation MMP27 TFPI2 23905012 853443 Positive_regulation MMP27 TFPI2 PMC2756345 496052 Positive_regulation MMP27 TGM2 24130925 204501 Positive_regulation MMP27 TLR7 17129374 107190 Positive_regulation MMP27 TLR7 23940584 2831646 Positive_regulation MMP27 TNF 14979937 100158 Positive_regulation MMP27 TNF 15987479 103887 Positive_regulation MMP27 TNF 17118171 3096349 Positive_regulation MMP27 TNF 18237379 379282 Positive_regulation MMP27 TNF 19226472 112806 Positive_regulation MMP27 TNF 19281072 1071662 Positive_regulation MMP27 TNF 19435506 113255 Positive_regulation MMP27 TNF 19889233 3097663 Positive_regulation MMP27 TNF 20126546 2439111 Positive_regulation MMP27 TNF 20126546 2439158 Positive_regulation MMP27 TNF 20543948 2452473 Positive_regulation MMP27 TNF 20871770 1047094 Positive_regulation MMP27 TNF 21912722 2223874 Positive_regulation MMP27 TNF 22005011 1697934 Positive_regulation MMP27 TNF 22315682 1687073 Positive_regulation MMP27 TNF 22778767 636631 Positive_regulation MMP27 TNF 23441116 1915724 Positive_regulation MMP27 TNF 23533687 2225594 Positive_regulation MMP27 TNF 23924945 1109768 Positive_regulation MMP27 TNF 24236107 2878524 Positive_regulation MMP27 TNF 24278882 1498591 Positive_regulation MMP27 TNF 24762063 401027 Positive_regulation MMP27 TNF 24926361 844270 Positive_regulation MMP27 TNF 24977073 1154279 Positive_regulation MMP27 TNF 25143751 645522 Positive_regulation MMP27 TNF 25147435 1761201 Positive_regulation MMP27 TNF 25250141 1148955 Positive_regulation MMP27 TNF 25356505 1132714 Positive_regulation MMP27 TSPAN1 23840773 2816938 Positive_regulation MMP27 WNT7A 24479426 131479 Positive_regulation MMP28 ACE 21887284 2549128 Positive_regulation MMP28 ADAM10 24244825 205156 Positive_regulation MMP28 ADAM11 24244825 205157 Positive_regulation MMP28 ADAM12 24244825 205158 Positive_regulation MMP28 ADAM15 24244825 205159 Positive_regulation MMP28 ADAM17 18046869 1071369 Positive_regulation MMP28 ADAM17 24244825 205160 Positive_regulation MMP28 ADAM18 24244825 205161 Positive_regulation MMP28 ADAM19 24244825 205162 Positive_regulation MMP28 ADAM2 24244825 205163 Positive_regulation MMP28 ADAM20 24244825 205164 Positive_regulation MMP28 ADAM21 24244825 205165 Positive_regulation MMP28 ADAM22 24244825 205166 Positive_regulation MMP28 ADAM23 24244825 205167 Positive_regulation MMP28 ADAM28 24244825 205168 Positive_regulation MMP28 ADAM29 24244825 205169 Positive_regulation MMP28 ADAM30 24244825 205170 Positive_regulation MMP28 ADAM32 24244825 205155 Positive_regulation MMP28 ADAM33 24244825 205154 Positive_regulation MMP28 ADAM5 24244825 205171 Positive_regulation MMP28 ADAM6 24244825 205172 Positive_regulation MMP28 ADAM7 24244825 205173 Positive_regulation MMP28 ADAM8 24244825 205174 Positive_regulation MMP28 ADAM9 24244825 205175 Positive_regulation MMP28 ADCY1 23249435 399005 Positive_regulation MMP28 ADCY10 23249435 399004 Positive_regulation MMP28 ADCY2 23249435 399006 Positive_regulation MMP28 ADCY3 23249435 399007 Positive_regulation MMP28 ADCY4 23249435 399008 Positive_regulation MMP28 ADCY5 23249435 399009 Positive_regulation MMP28 ADCY6 23249435 399010 Positive_regulation MMP28 ADCY7 23249435 399011 Positive_regulation MMP28 ADCY8 23249435 399012 Positive_regulation MMP28 ADCY9 23249435 399013 Positive_regulation MMP28 ADIPOQ 21194467 121299 Positive_regulation MMP28 ADIPOQ 21194467 121325 Positive_regulation MMP28 ADIPOQ 24434628 840321 Positive_regulation MMP28 ADIPOQ 24667577 2938839 Positive_regulation MMP28 AGR2 17129374 107077 Positive_regulation MMP28 AGR2 17129374 107078 Positive_regulation MMP28 AGR3 17129374 107075 Positive_regulation MMP28 AGR3 17129374 107076 Positive_regulation MMP28 AHR 22500183 1156049 Positive_regulation MMP28 AKT1 23061721 533331 Positive_regulation MMP28 AKT1 23383143 2748152 Positive_regulation MMP28 AKT1 23797661 1107847 Positive_regulation MMP28 AKT1 25036034 1128503 Positive_regulation MMP28 AKT1 25147440 1761422 Positive_regulation MMP28 AKT2 23061721 533332 Positive_regulation MMP28 AKT2 23383143 2748153 Positive_regulation MMP28 AKT2 23797661 1107848 Positive_regulation MMP28 AKT2 25036034 1128504 Positive_regulation MMP28 AKT2 25147440 1761423 Positive_regulation MMP28 AKT3 23061721 533333 Positive_regulation MMP28 AKT3 23383143 2748154 Positive_regulation MMP28 AKT3 23797661 1107849 Positive_regulation MMP28 AKT3 25036034 1128505 Positive_regulation MMP28 AKT3 25147440 1761424 Positive_regulation MMP28 ANGPT2 18493299 2389198 Positive_regulation MMP28 ANGPT2 23161900 91190 Positive_regulation MMP28 ANGPT2 24811612 1159602 Positive_regulation MMP28 ANXA2 24884814 273087 Positive_regulation MMP28 APOB 17714581 507698 Positive_regulation MMP28 AREG 25147440 1761679 Positive_regulation MMP28 ARG1 19405959 463802 Positive_regulation MMP28 ARG2 19405959 463803 Positive_regulation MMP28 ASIP 19405959 463804 Positive_regulation MMP28 AWAT2 PMC2938647 3157366 Positive_regulation MMP28 BAX 12756268 1527131 Positive_regulation MMP28 BAX 12756268 1527210 Positive_regulation MMP28 BAX 12925707 1295653 Positive_regulation MMP28 BAX 18516228 3041431 Positive_regulation MMP28 BAX 21347304 2503560 Positive_regulation MMP28 BAX 21654827 552269 Positive_regulation MMP28 BAX 22419111 555199 Positive_regulation MMP28 BAX 22550588 154881 Positive_regulation MMP28 BAX 24705500 1730604 Positive_regulation MMP28 BAX 24959718 2983119 Positive_regulation MMP28 BAX 25278781 1478825 Positive_regulation MMP28 BCL10 23437193 2756043 Positive_regulation MMP28 BCL2 11181702 1518656 Positive_regulation MMP28 BCL2 20043854 402221 Positive_regulation MMP28 BCL2 22458888 3084443 Positive_regulation MMP28 BCL2 23437193 2756044 Positive_regulation MMP28 BCL2 24808916 825797 Positive_regulation MMP28 BCL2 24808916 825862 Positive_regulation MMP28 BCL3 23437193 2756045 Positive_regulation MMP28 BCL5 23437193 2756040 Positive_regulation MMP28 BCL6 23437193 2756041 Positive_regulation MMP28 BCL9 23437193 2756042 Positive_regulation MMP28 BDKRB1 21729302 3101233 Positive_regulation MMP28 BDKRB2 21729302 3101234 Positive_regulation MMP28 BMP4 24053318 269708 Positive_regulation MMP28 BNIP3 22292033 2592039 Positive_regulation MMP28 BRMS1 24879377 2975615 Positive_regulation MMP28 BSG 16207318 104105 Positive_regulation MMP28 BSG 16207318 104149 Positive_regulation MMP28 BSG 16207318 104171 Positive_regulation MMP28 BSG 18596970 2392424 Positive_regulation MMP28 BSG 19664212 116358 Positive_regulation MMP28 BSG 19775453 254230 Positive_regulation MMP28 BSG 19775453 254231 Positive_regulation MMP28 BSG 20540754 3098453 Positive_regulation MMP28 BSG 20540754 3098497 Positive_regulation MMP28 BSG 20540754 3098519 Positive_regulation MMP28 BSG 20540754 3098541 Positive_regulation MMP28 BSG 21762534 260581 Positive_regulation MMP28 BSG 22480370 1661454 Positive_regulation MMP28 BSG 22782346 438976 Positive_regulation MMP28 BSG 23167819 1626744 Positive_regulation MMP28 BSG 23922889 2827256 Positive_regulation MMP28 BSG 23922889 2827257 Positive_regulation MMP28 BSG 24281180 502088 Positive_regulation MMP28 BSG 24281180 502132 Positive_regulation MMP28 BSG 24739808 1126154 Positive_regulation MMP28 BSG 25076423 2993237 Positive_regulation MMP28 BSG 25076423 2993238 Positive_regulation MMP28 BSG 25268615 1131344 Positive_regulation MMP28 BSG 25268615 1131443 Positive_regulation MMP28 BSG 25404518 133849 Positive_regulation MMP28 BST1 22916288 2680654 Positive_regulation MMP28 C4BPA 25115920 2996508 Positive_regulation MMP28 CA2 18516228 3041334 Positive_regulation MMP28 CA2 22536507 154856 Positive_regulation MMP28 CA2 23233904 941652 Positive_regulation MMP28 CA2 24739681 3210942 Positive_regulation MMP28 CA2 24739681 3210964 Positive_regulation MMP28 CAPN1 18493299 2388912 Positive_regulation MMP28 CAPN1 21911754 720033 Positive_regulation MMP28 CAPN10 18493299 2388913 Positive_regulation MMP28 CAPN10 21911754 720034 Positive_regulation MMP28 CAPN11 18493299 2388914 Positive_regulation MMP28 CAPN11 21911754 720035 Positive_regulation MMP28 CAPN12 18493299 2388911 Positive_regulation MMP28 CAPN12 21911754 720032 Positive_regulation MMP28 CAPN13 18493299 2388922 Positive_regulation MMP28 CAPN13 21911754 720044 Positive_regulation MMP28 CAPN14 18493299 2388923 Positive_regulation MMP28 CAPN14 21911754 720045 Positive_regulation MMP28 CAPN15 18493299 2388910 Positive_regulation MMP28 CAPN15 21911754 720031 Positive_regulation MMP28 CAPN2 18493299 2388915 Positive_regulation MMP28 CAPN2 21911754 720036 Positive_regulation MMP28 CAPN3 18493299 2388916 Positive_regulation MMP28 CAPN3 21911754 720037 Positive_regulation MMP28 CAPN5 18493299 2388917 Positive_regulation MMP28 CAPN5 21911754 720038 Positive_regulation MMP28 CAPN6 18493299 2388918 Positive_regulation MMP28 CAPN6 21911754 720039 Positive_regulation MMP28 CAPN7 18493299 2388919 Positive_regulation MMP28 CAPN7 21911754 720040 Positive_regulation MMP28 CAPN8 18493299 2388920 Positive_regulation MMP28 CAPN8 21911754 720041 Positive_regulation MMP28 CAPN9 18493299 2388921 Positive_regulation MMP28 CAPN9 21911754 720042 Positive_regulation MMP28 CASP3 18629305 793064 Positive_regulation MMP28 CASP3 19468318 1088267 Positive_regulation MMP28 CASP3 19468318 1088314 Positive_regulation MMP28 CASP3 19966836 8446 Positive_regulation MMP28 CASP3 20111678 1089055 Positive_regulation MMP28 CASP3 20111678 1089143 Positive_regulation MMP28 CASP3 21423690 812422 Positive_regulation MMP28 CASP3 21595920 1697317 Positive_regulation MMP28 CASP3 22140470 2574782 Positive_regulation MMP28 CASP3 23202971 1098945 Positive_regulation MMP28 CASP3 23552194 294313 Positive_regulation MMP28 CASP3 23667640 2790841 Positive_regulation MMP28 CASP3 24324518 824441 Positive_regulation MMP28 CASP3 25401052 692013 Positive_regulation MMP28 CASP3 PMC3871853 1136400 Positive_regulation MMP28 CASP8 23752353 1729802 Positive_regulation MMP28 CASP8 24324518 824442 Positive_regulation MMP28 CASP8 24705500 1730602 Positive_regulation MMP28 CASP9 18629305 793065 Positive_regulation MMP28 CASP9 19468318 1088268 Positive_regulation MMP28 CASP9 19468318 1088315 Positive_regulation MMP28 CASP9 23752353 1729803 Positive_regulation MMP28 CASP9 24705500 1730603 Positive_regulation MMP28 CASP9 24959718 2983165 Positive_regulation MMP28 CASP9 PMC3871853 1136401 Positive_regulation MMP28 CAST 21911754 720043 Positive_regulation MMP28 CAV1 18596970 2392375 Positive_regulation MMP28 CAV1 22842734 15795 Positive_regulation MMP28 CAV1 23922889 2827258 Positive_regulation MMP28 CCL2 20604932 119407 Positive_regulation MMP28 CCL25 20649989 3226111 Positive_regulation MMP28 CCL4 22013489 813338 Positive_regulation MMP28 CCL4 22872786 178237 Positive_regulation MMP28 CCL5 20604932 119408 Positive_regulation MMP28 CCL5 20604932 119476 Positive_regulation MMP28 CCND1 22942717 1097087 Positive_regulation MMP28 CCR7 19363519 7271 Positive_regulation MMP28 CCR7 19363519 7386 Positive_regulation MMP28 CCR9 20649989 3226156 Positive_regulation MMP28 CD2 18629305 793348 Positive_regulation MMP28 CD24 PMC2756345 496057 Positive_regulation MMP28 CD44 21179550 2489058 Positive_regulation MMP28 CD9 23840773 2817472 Positive_regulation MMP28 CD9 23840773 2817525 Positive_regulation MMP28 CDH1 15668718 425238 Positive_regulation MMP28 CDH1 23365639 2745207 Positive_regulation MMP28 CDK1 18516228 3041371 Positive_regulation MMP28 CDKN2A 24572376 132001 Positive_regulation MMP28 CLDN6 19920867 1213273 Positive_regulation MMP28 CNGA1 22699690 621454 Positive_regulation MMP28 CNGB1 22699690 621455 Positive_regulation MMP28 CPP 25157203 1605593 Positive_regulation MMP28 CRP 23508642 1710048 Positive_regulation MMP28 CTSB 23936808 182982 Positive_regulation MMP28 CTSK 22046029 739157 Positive_regulation MMP28 CTTN 24531055 502985 Positive_regulation MMP28 CXCL12 22295222 1065001 Positive_regulation MMP28 CXCL12 22675496 2649041 Positive_regulation MMP28 CXCL12 24472670 411652 Positive_regulation MMP28 CXCL13 20412587 1854063 Positive_regulation MMP28 CXCR4 19363519 7317 Positive_regulation MMP28 CXCR4 22295222 1065002 Positive_regulation MMP28 CXCR4 23116176 3215139 Positive_regulation MMP28 CXCR4 24472670 411653 Positive_regulation MMP28 CYCS 15312229 3115307 Positive_regulation MMP28 CYCS 24566142 1124142 Positive_regulation MMP28 CYCS 25505905 23450 Positive_regulation MMP28 DST 23110919 1639843 Positive_regulation MMP28 E2F1 25029110 2989971 Positive_regulation MMP28 EARS2 24130267 91483 Positive_regulation MMP28 ECM1 12100737 457401 Positive_regulation MMP28 ECM1 19298660 352692 Positive_regulation MMP28 ECM1 20540754 3098367 Positive_regulation MMP28 ECM1 23840773 2817383 Positive_regulation MMP28 ECM1 8976186 1599615 Positive_regulation MMP28 ECM2 12100737 457402 Positive_regulation MMP28 ECM2 19298660 352693 Positive_regulation MMP28 ECM2 20540754 3098368 Positive_regulation MMP28 ECM2 23840773 2817384 Positive_regulation MMP28 ECM2 8976186 1599616 Positive_regulation MMP28 EDNRA 20953374 506643 Positive_regulation MMP28 EDNRB 20953374 506644 Positive_regulation MMP28 EFEMP2 25255451 3010435 Positive_regulation MMP28 EGF 19375502 1731651 Positive_regulation MMP28 EGF 22627809 834800 Positive_regulation MMP28 EGF 22860018 2670872 Positive_regulation MMP28 EGF 22860018 2670931 Positive_regulation MMP28 EGFR 20667128 1857514 Positive_regulation MMP28 EGFR 21151531 1081341 Positive_regulation MMP28 EGFR 22675459 2648626 Positive_regulation MMP28 EGFR 24362507 502569 Positive_regulation MMP28 EGFR 24872356 2252188 Positive_regulation MMP28 EGFR 24872356 2252235 Positive_regulation MMP28 EGFR 25147440 1761646 Positive_regulation MMP28 EGFR 25356505 1132731 Positive_regulation MMP28 EGFR 25356505 1132732 Positive_regulation MMP28 EGFR 25356505 1132733 Positive_regulation MMP28 ELK1 23231703 267212 Positive_regulation MMP28 ELL 12975354 1297287 Positive_regulation MMP28 ELN 24946848 1087463 Positive_regulation MMP28 EPHB2 18629305 793066 Positive_regulation MMP28 EPHB2 21738525 922796 Positive_regulation MMP28 EPHB2 22310287 2146200 Positive_regulation MMP28 EPHB2 23663277 1678760 Positive_regulation MMP28 EPHB2 23671446 95479 Positive_regulation MMP28 EPHB2 24084727 1113129 Positive_regulation MMP28 ETS1 15165288 1694939 Positive_regulation MMP28 ETS1 22971289 472169 Positive_regulation MMP28 ETS1 22971289 472252 Positive_regulation MMP28 ETS1 24281073 501513 Positive_regulation MMP28 ETS2 15165288 1694940 Positive_regulation MMP28 ETS2 24281073 501514 Positive_regulation MMP28 ETV4 25506469 3209611 Positive_regulation MMP28 EXOC7 23557484 166588 Positive_regulation MMP28 FASLG 23698793 3136048 Positive_regulation MMP28 FGF2 10684258 1255983 Positive_regulation MMP28 FGF2 8554978 445127 Positive_regulation MMP28 FN1 18001488 109399 Positive_regulation MMP28 FN1 23259712 856294 Positive_regulation MMP28 FOS 25205949 90108 Positive_regulation MMP28 FURIN 11044366 418052 Positive_regulation MMP28 FURIN 19375502 1731655 Positive_regulation MMP28 FURIN 21152186 154471 Positive_regulation MMP28 FURIN 21152186 154472 Positive_regulation MMP28 FURIN 21152186 154473 Positive_regulation MMP28 FURIN 21152186 154477 Positive_regulation MMP28 FURIN 21152186 154479 Positive_regulation MMP28 FURIN 23936445 2830466 Positive_regulation MMP28 GLRX 18560520 2390904 Positive_regulation MMP28 GLRX 18560520 2390905 Positive_regulation MMP28 GLRX 18560520 2391034 Positive_regulation MMP28 GPI 24736611 2953198 Positive_regulation MMP28 GPR1 24066041 2849120 Positive_regulation MMP28 GPR101 24066041 2849076 Positive_regulation MMP28 GPR107 24066041 2849081 Positive_regulation MMP28 GPR108 24066041 2849080 Positive_regulation MMP28 GPR110 24066041 2849086 Positive_regulation MMP28 GPR111 24066041 2849087 Positive_regulation MMP28 GPR112 24066041 2849088 Positive_regulation MMP28 GPR113 24066041 2849085 Positive_regulation MMP28 GPR114 24066041 2849089 Positive_regulation MMP28 GPR115 24066041 2849090 Positive_regulation MMP28 GPR116 24066041 2849091 Positive_regulation MMP28 GPR119 24066041 2849092 Positive_regulation MMP28 GPR12 24066041 2849121 Positive_regulation MMP28 GPR123 24066041 2849073 Positive_regulation MMP28 GPR124 24066041 2849082 Positive_regulation MMP28 GPR125 24066041 2849074 Positive_regulation MMP28 GPR126 24066041 2849075 Positive_regulation MMP28 GPR128 24066041 2849093 Positive_regulation MMP28 GPR132 24066041 2849079 Positive_regulation MMP28 GPR133 24066041 2849094 Positive_regulation MMP28 GPR135 24066041 2849095 Positive_regulation MMP28 GPR137 24066041 2849113 Positive_regulation MMP28 GPR139 24066041 2849096 Positive_regulation MMP28 GPR141 24066041 2849097 Positive_regulation MMP28 GPR142 24066041 2849098 Positive_regulation MMP28 GPR143 24066041 2849099 Positive_regulation MMP28 GPR144 24066041 2849084 Positive_regulation MMP28 GPR146 24066041 2849101 Positive_regulation MMP28 GPR148 24066041 2849105 Positive_regulation MMP28 GPR149 24066041 2849107 Positive_regulation MMP28 GPR15 24066041 2849122 Positive_regulation MMP28 GPR150 24066041 2849108 Positive_regulation MMP28 GPR151 24066041 2849106 Positive_regulation MMP28 GPR152 24066041 2849104 Positive_regulation MMP28 GPR153 24066041 2849103 Positive_regulation MMP28 GPR155 24066041 2849102 Positive_regulation MMP28 GPR156 24066041 2849100 Positive_regulation MMP28 GPR157 24066041 2849109 Positive_regulation MMP28 GPR158 24066041 2849110 Positive_regulation MMP28 GPR160 24066041 2849111 Positive_regulation MMP28 GPR161 24066041 2849112 Positive_regulation MMP28 GPR162 24066041 2849077 Positive_regulation MMP28 GPR17 24066041 2849123 Positive_regulation MMP28 GPR171 24066041 2849115 Positive_regulation MMP28 GPR173 24066041 2849083 Positive_regulation MMP28 GPR174 24066041 2849116 Positive_regulation MMP28 GPR176 24066041 2849119 Positive_regulation MMP28 GPR179 24066041 2849118 Positive_regulation MMP28 GPR18 24066041 2849124 Positive_regulation MMP28 GPR180 24066041 2849114 Positive_regulation MMP28 GPR182 24066041 2849071 Positive_regulation MMP28 GPR183 24066041 2849117 Positive_regulation MMP28 GPR19 24066041 2849125 Positive_regulation MMP28 GPR20 24066041 2849126 Positive_regulation MMP28 GPR21 24066041 2849127 Positive_regulation MMP28 GPR22 24066041 2849128 Positive_regulation MMP28 GPR25 24066041 2849129 Positive_regulation MMP28 GPR26 24066041 2849130 Positive_regulation MMP28 GPR27 24066041 2849131 Positive_regulation MMP28 GPR3 24066041 2849132 Positive_regulation MMP28 GPR31 24066041 2849133 Positive_regulation MMP28 GPR32 24066041 2849134 Positive_regulation MMP28 GPR33 24066041 2849135 Positive_regulation MMP28 GPR34 24066041 2849136 Positive_regulation MMP28 GPR35 24066041 2849137 Positive_regulation MMP28 GPR36 24066041 2849138 Positive_regulation MMP28 GPR37 24066041 2849139 Positive_regulation MMP28 GPR39 24066041 2849140 Positive_regulation MMP28 GPR4 24066041 2849141 Positive_regulation MMP28 GPR42 24066041 2849142 Positive_regulation MMP28 GPR45 24066041 2849143 Positive_regulation MMP28 GPR50 24066041 2849144 Positive_regulation MMP28 GPR52 24066041 2849145 Positive_regulation MMP28 GPR55 24066041 2849146 Positive_regulation MMP28 GPR56 24066041 2849147 Positive_regulation MMP28 GPR6 24066041 2849148 Positive_regulation MMP28 GPR61 24066041 2849068 Positive_regulation MMP28 GPR62 24066041 2849069 Positive_regulation MMP28 GPR63 24066041 2849070 Positive_regulation MMP28 GPR64 24066041 2849149 Positive_regulation MMP28 GPR65 24066041 2849150 Positive_regulation MMP28 GPR68 24066041 2849151 Positive_regulation MMP28 GPR75 24066041 2849153 Positive_regulation MMP28 GPR78 24066041 2849154 Positive_regulation MMP28 GPR79 24066041 2849155 Positive_regulation MMP28 GPR82 24066041 2849156 Positive_regulation MMP28 GPR83 24066041 2849152 Positive_regulation MMP28 GPR84 24066041 2849157 Positive_regulation MMP28 GPR85 24066041 2849158 Positive_regulation MMP28 GPR87 24066041 2849159 Positive_regulation MMP28 GPR88 24066041 2849160 Positive_regulation MMP28 GPR97 24066041 2849072 Positive_regulation MMP28 GPR98 24066041 2849078 Positive_regulation MMP28 GRAP2 24084727 1113130 Positive_regulation MMP28 HBEGF 21179550 2489059 Positive_regulation MMP28 HDAC1 15899037 102896 Positive_regulation MMP28 HDAC1 15899037 102897 Positive_regulation MMP28 HDAC1 21143861 379624 Positive_regulation MMP28 HDAC1 24062615 1628641 Positive_regulation MMP28 HDAC10 15899037 102892 Positive_regulation MMP28 HDAC10 15899037 102893 Positive_regulation MMP28 HDAC11 15899037 102894 Positive_regulation MMP28 HDAC11 15899037 102895 Positive_regulation MMP28 HDAC2 15899037 102898 Positive_regulation MMP28 HDAC2 15899037 102899 Positive_regulation MMP28 HDAC2 21143861 379625 Positive_regulation MMP28 HDAC2 24062615 1628642 Positive_regulation MMP28 HDAC3 15899037 102900 Positive_regulation MMP28 HDAC3 15899037 102901 Positive_regulation MMP28 HDAC4 15899037 102882 Positive_regulation MMP28 HDAC4 15899037 102883 Positive_regulation MMP28 HDAC5 15899037 102890 Positive_regulation MMP28 HDAC5 15899037 102891 Positive_regulation MMP28 HDAC6 15899037 102884 Positive_regulation MMP28 HDAC6 15899037 102885 Positive_regulation MMP28 HDAC7 15899037 102888 Positive_regulation MMP28 HDAC7 15899037 102889 Positive_regulation MMP28 HDAC8 15899037 102880 Positive_regulation MMP28 HDAC8 15899037 102881 Positive_regulation MMP28 HDAC9 15899037 102886 Positive_regulation MMP28 HDAC9 15899037 102887 Positive_regulation MMP28 HGF 19375502 1731652 Positive_regulation MMP28 HGF 20551596 3078664 Positive_regulation MMP28 HNRNPK 24885469 273252 Positive_regulation MMP28 HRAS 23365639 2745208 Positive_regulation MMP28 HSPD1 23956742 1146924 Positive_regulation MMP28 IFI44 20109185 284121 Positive_regulation MMP28 IGF1 19375502 1731653 Positive_regulation MMP28 IGF1 22860018 2670873 Positive_regulation MMP28 IGF1 24717414 1703634 Positive_regulation MMP28 IGF1 24717414 1703680 Positive_regulation MMP28 IL11 25352758 1716790 Positive_regulation MMP28 IL13 24904424 954575 Positive_regulation MMP28 IL17A 15987479 103857 Positive_regulation MMP28 IL17A 15987479 103892 Positive_regulation MMP28 IL17A 19627579 116110 Positive_regulation MMP28 IL17A 19627579 116159 Positive_regulation MMP28 IL17A 19627579 116249 Positive_regulation MMP28 IL17A 23372655 2745634 Positive_regulation MMP28 IL17A 24022789 1919971 Positive_regulation MMP28 IL18 11805151 1522689 Positive_regulation MMP28 IL1A 15380034 101696 Positive_regulation MMP28 IL1A 15566575 3104152 Positive_regulation MMP28 IL1A 15743487 102592 Positive_regulation MMP28 IL1A 16207333 104425 Positive_regulation MMP28 IL1A 16262900 3105755 Positive_regulation MMP28 IL1A 16792821 106151 Positive_regulation MMP28 IL1A 17096856 1695558 Positive_regulation MMP28 IL1A 17925024 109227 Positive_regulation MMP28 IL1A 18604259 810791 Positive_regulation MMP28 IL1A 19226472 112815 Positive_regulation MMP28 IL1A 19296842 113011 Positive_regulation MMP28 IL1A 19309495 3226023 Positive_regulation MMP28 IL1A 19375502 1731654 Positive_regulation MMP28 IL1A 19567787 2251160 Positive_regulation MMP28 IL1A 19765281 116760 Positive_regulation MMP28 IL1A 19765281 116761 Positive_regulation MMP28 IL1A 19765281 117206 Positive_regulation MMP28 IL1A 19919704 117791 Positive_regulation MMP28 IL1A 19919704 117837 Positive_regulation MMP28 IL1A 20307272 118431 Positive_regulation MMP28 IL1A 20307272 118432 Positive_regulation MMP28 IL1A 20307272 118476 Positive_regulation MMP28 IL1A 20307272 118500 Positive_regulation MMP28 IL1A 20307272 118523 Positive_regulation MMP28 IL1A 20307272 118546 Positive_regulation MMP28 IL1A 20360891 1078103 Positive_regulation MMP28 IL1A 20799933 119755 Positive_regulation MMP28 IL1A 21801383 1652104 Positive_regulation MMP28 IL1A 22046527 97435 Positive_regulation MMP28 IL1A 22359588 2597958 Positive_regulation MMP28 IL1A 22359588 2598163 Positive_regulation MMP28 IL1A 23342250 491464 Positive_regulation MMP28 IL1A 23342250 491465 Positive_regulation MMP28 IL1A 23342250 491466 Positive_regulation MMP28 IL1A 23342250 491467 Positive_regulation MMP28 IL1A 23342250 491468 Positive_regulation MMP28 IL1A 23342250 491469 Positive_regulation MMP28 IL1A 23342250 491645 Positive_regulation MMP28 IL1A 23342250 491667 Positive_regulation MMP28 IL1A 23342250 491715 Positive_regulation MMP28 IL1A 23342250 491737 Positive_regulation MMP28 IL1A 23658758 2790161 Positive_regulation MMP28 IL1A 23889808 1627216 Positive_regulation MMP28 IL1A 23965253 129136 Positive_regulation MMP28 IL1A 24236107 2878529 Positive_regulation MMP28 IL1A 24238405 129963 Positive_regulation MMP28 IL1A 24349175 2896930 Positive_regulation MMP28 IL1A 24349175 2897003 Positive_regulation MMP28 IL1A 24556326 3209476 Positive_regulation MMP28 IL1A 24817792 1758480 Positive_regulation MMP28 IL1A 24977073 1154286 Positive_regulation MMP28 IL1A 24984954 132765 Positive_regulation MMP28 IL1A 24984954 132825 Positive_regulation MMP28 IL1A 25143751 645529 Positive_regulation MMP28 IL1A 25312962 1485586 Positive_regulation MMP28 IL1B 15203568 1739660 Positive_regulation MMP28 IL6 19883500 117564 Positive_regulation MMP28 IL6 20543948 2452478 Positive_regulation MMP28 IL6 21484455 1718747 Positive_regulation MMP28 IL6 24977073 1154287 Positive_regulation MMP28 IL8 19883500 117565 Positive_regulation MMP28 IL8 21278918 1056992 Positive_regulation MMP28 IL8 22891766 245248 Positive_regulation MMP28 IL8 24912917 1043550 Positive_regulation MMP28 INHBA 25075578 454133 Positive_regulation MMP28 ITGA2 21288331 855246 Positive_regulation MMP28 ITIH4 22132194 2574417 Positive_regulation MMP28 ITIH4 22132194 2574418 Positive_regulation MMP28 ITIH4 22132194 2574503 Positive_regulation MMP28 JUN 14979937 100189 Positive_regulation MMP28 JUN 15770046 1739808 Positive_regulation MMP28 JUN 16552434 427248 Positive_regulation MMP28 JUN 17559674 108293 Positive_regulation MMP28 JUN 23226337 2724144 Positive_regulation MMP28 JUN 23467702 696401 Positive_regulation MMP28 JUN 23551430 1480176 Positive_regulation MMP28 JUN 24212934 499132 Positive_regulation MMP28 JUN 24281073 501515 Positive_regulation MMP28 JUN 24349175 2896931 Positive_regulation MMP28 JUN 24976858 1650856 Positive_regulation MMP28 JUN 25205949 90109 Positive_regulation MMP28 KLF8 21151179 2136985 Positive_regulation MMP28 KRAS 23365639 2745209 Positive_regulation MMP28 KRT13 23552603 2156185 Positive_regulation MMP28 L1CAM 21541352 2517060 Positive_regulation MMP28 LAMA3 23110919 1639844 Positive_regulation MMP28 LAMB1 23110919 1639845 Positive_regulation MMP28 LAMC1 23110919 1639846 Positive_regulation MMP28 LEP 21826146 1144690 Positive_regulation MMP28 LPA 21151531 1081342 Positive_regulation MMP28 LPA 22627809 834801 Positive_regulation MMP28 LPA 25356505 1132734 Positive_regulation MMP28 LPAR1 25356505 1132729 Positive_regulation MMP28 LPAR1 25356505 1132730 Positive_regulation MMP28 LTB 12516548 2001366 Positive_regulation MMP28 MAP2K1 20667128 1857515 Positive_regulation MMP28 MAP2K2 20667128 1857516 Positive_regulation MMP28 MAP2K3 20667128 1857517 Positive_regulation MMP28 MAP2K4 20667128 1857518 Positive_regulation MMP28 MAP2K4 22353730 124758 Positive_regulation MMP28 MAP2K5 20667128 1857519 Positive_regulation MMP28 MAP2K6 20667128 1857520 Positive_regulation MMP28 MAP2K7 20667128 1857521 Positive_regulation MMP28 MAP2K7 22353730 124759 Positive_regulation MMP28 MAPK1 20667128 1857235 Positive_regulation MMP28 MAPK1 20667128 1857666 Positive_regulation MMP28 MAPK1 22570668 634491 Positive_regulation MMP28 MAPK1 23671446 95480 Positive_regulation MMP28 MAPK1 23760725 2164953 Positive_regulation MMP28 MAPK1 24204703 2873567 Positive_regulation MMP28 MAPK1 25520932 202950 Positive_regulation MMP28 MAPK10 20667128 1857236 Positive_regulation MMP28 MAPK10 22570668 634492 Positive_regulation MMP28 MAPK10 23671446 95481 Positive_regulation MMP28 MAPK10 23760725 2164954 Positive_regulation MMP28 MAPK10 24204703 2873568 Positive_regulation MMP28 MAPK10 25520932 202951 Positive_regulation MMP28 MAPK11 20667128 1857237 Positive_regulation MMP28 MAPK11 22570668 634493 Positive_regulation MMP28 MAPK11 23671446 95482 Positive_regulation MMP28 MAPK11 23760725 2164955 Positive_regulation MMP28 MAPK11 24204703 2873569 Positive_regulation MMP28 MAPK11 25520932 202952 Positive_regulation MMP28 MAPK12 20667128 1857238 Positive_regulation MMP28 MAPK12 22570668 634494 Positive_regulation MMP28 MAPK12 23671446 95483 Positive_regulation MMP28 MAPK12 23760725 2164956 Positive_regulation MMP28 MAPK12 24204703 2873570 Positive_regulation MMP28 MAPK12 25520932 202953 Positive_regulation MMP28 MAPK13 20667128 1857239 Positive_regulation MMP28 MAPK13 22570668 634495 Positive_regulation MMP28 MAPK13 23671446 95484 Positive_regulation MMP28 MAPK13 23760725 2164957 Positive_regulation MMP28 MAPK13 24204703 2873571 Positive_regulation MMP28 MAPK13 25520932 202954 Positive_regulation MMP28 MAPK14 20667128 1857240 Positive_regulation MMP28 MAPK14 22570668 634496 Positive_regulation MMP28 MAPK14 23671446 95485 Positive_regulation MMP28 MAPK14 23760725 2164958 Positive_regulation MMP28 MAPK14 24204703 2873572 Positive_regulation MMP28 MAPK14 25520932 202955 Positive_regulation MMP28 MAPK15 20667128 1857234 Positive_regulation MMP28 MAPK15 22570668 634490 Positive_regulation MMP28 MAPK15 23671446 95478 Positive_regulation MMP28 MAPK15 23760725 2164952 Positive_regulation MMP28 MAPK15 24204703 2873566 Positive_regulation MMP28 MAPK15 25520932 202949 Positive_regulation MMP28 MAPK3 20667128 1857241 Positive_regulation MMP28 MAPK3 20667128 1857667 Positive_regulation MMP28 MAPK3 22570668 634497 Positive_regulation MMP28 MAPK3 23671446 95486 Positive_regulation MMP28 MAPK3 23760725 2164959 Positive_regulation MMP28 MAPK3 24204703 2873573 Positive_regulation MMP28 MAPK3 25520932 202956 Positive_regulation MMP28 MAPK4 20667128 1857242 Positive_regulation MMP28 MAPK4 22570668 634498 Positive_regulation MMP28 MAPK4 23671446 95487 Positive_regulation MMP28 MAPK4 23760725 2164960 Positive_regulation MMP28 MAPK4 24204703 2873574 Positive_regulation MMP28 MAPK4 25520932 202957 Positive_regulation MMP28 MAPK6 20667128 1857243 Positive_regulation MMP28 MAPK6 22570668 634499 Positive_regulation MMP28 MAPK6 23671446 95488 Positive_regulation MMP28 MAPK6 23760725 2164961 Positive_regulation MMP28 MAPK6 24204703 2873575 Positive_regulation MMP28 MAPK6 25520932 202958 Positive_regulation MMP28 MAPK7 20667128 1857244 Positive_regulation MMP28 MAPK7 22570668 634500 Positive_regulation MMP28 MAPK7 23671446 95489 Positive_regulation MMP28 MAPK7 23760725 2164962 Positive_regulation MMP28 MAPK7 24204703 2873576 Positive_regulation MMP28 MAPK7 25520932 202959 Positive_regulation MMP28 MAPK8 20667128 1857245 Positive_regulation MMP28 MAPK8 22570668 634501 Positive_regulation MMP28 MAPK8 23028407 2219688 Positive_regulation MMP28 MAPK8 23671446 95490 Positive_regulation MMP28 MAPK8 23760725 2164963 Positive_regulation MMP28 MAPK8 24204703 2873577 Positive_regulation MMP28 MAPK8 25520932 202960 Positive_regulation MMP28 MAPK9 20667128 1857246 Positive_regulation MMP28 MAPK9 22570668 634502 Positive_regulation MMP28 MAPK9 23671446 95491 Positive_regulation MMP28 MAPK9 23760725 2164964 Positive_regulation MMP28 MAPK9 24204703 2873578 Positive_regulation MMP28 MAPK9 25520932 202961 Positive_regulation MMP28 MCAT 25133539 2998683 Positive_regulation MMP28 MCL1 21304825 2499974 Positive_regulation MMP28 MCS 23342045 2741820 Positive_regulation MMP28 MDM2 24236052 2878290 Positive_regulation MMP28 MFN2 22438978 2612480 Positive_regulation MMP28 MIF 19435478 113180 Positive_regulation MMP28 MIF 23050964 89477 Positive_regulation MMP28 MIF 24069610 184242 Positive_regulation MMP28 MIF 24586879 2927825 Positive_regulation MMP28 MIP 21347304 2503596 Positive_regulation MMP28 MIR21 23788041 563259 Positive_regulation MMP28 MIR9-2 23820254 441069 Positive_regulation MMP28 MIR9-2 23820254 441070 Positive_regulation MMP28 MME 22642296 1230699 Positive_regulation MMP28 MMP1 19226472 112816 Positive_regulation MMP28 MMP1 8554978 445128 Positive_regulation MMP28 MMP10 20204159 1671967 Positive_regulation MMP28 MMP13 21787393 229494 Positive_regulation MMP28 MMP13 23028407 2219809 Positive_regulation MMP28 MMP2 11401321 419022 Positive_regulation MMP28 MMP2 20587068 256532 Positive_regulation MMP28 MMP2 21729302 3101235 Positive_regulation MMP28 MMP2 23388158 521771 Positive_regulation MMP28 MMP2 24441189 806912 Positive_regulation MMP28 MMP2 24806521 2962426 Positive_regulation MMP28 MMP3 19226472 112817 Positive_regulation MMP28 MMP8 20442866 3046732 Positive_regulation MMP28 MMP9 21729302 3101236 Positive_regulation MMP28 MMP9 21787393 229495 Positive_regulation MMP28 MMP9 24465581 2910798 Positive_regulation MMP28 MRC1 23937653 380345 Positive_regulation MMP28 MRC2 23937653 380344 Positive_regulation MMP28 MSC 23236386 2726049 Positive_regulation MMP28 MSC 24775918 3114571 Positive_regulation MMP28 MSLN 23694968 3135897 Positive_regulation MMP28 MTOR 18516228 3041372 Positive_regulation MMP28 MUC16 23694968 3135779 Positive_regulation MMP28 MYC 23365639 2745210 Positive_regulation MMP28 MYLIP 23820254 441161 Positive_regulation MMP28 MYLIP 23857777 781426 Positive_regulation MMP28 NA 21192843 623498 Positive_regulation MMP28 NA 21569548 259727 Positive_regulation MMP28 NA 21991373 2561598 Positive_regulation MMP28 NA 23760725 2164965 Positive_regulation MMP28 NA 24260080 2167078 Positive_regulation MMP28 NA 25019272 2988632 Positive_regulation MMP28 NAMPT 23797661 1107846 Positive_regulation MMP28 NCOA3 21577200 2139484 Positive_regulation MMP28 NFKB1 15770046 1739809 Positive_regulation MMP28 NFKB1 22570691 2631210 Positive_regulation MMP28 NFKB1 23226337 2724145 Positive_regulation MMP28 NFKB1 23482348 2182540 Positive_regulation MMP28 NOS2 22936987 2682623 Positive_regulation MMP28 NOS2 23894457 2824752 Positive_regulation MMP28 NOTCH1 24749110 1022441 Positive_regulation MMP28 NOTCH2 24749110 1022442 Positive_regulation MMP28 NOTCH3 24749110 1022443 Positive_regulation MMP28 NOTCH4 24749110 1022444 Positive_regulation MMP28 NOV 22353423 1661122 Positive_regulation MMP28 NOX1 23840100 1753628 Positive_regulation MMP28 NOX3 23840100 1753629 Positive_regulation MMP28 NOX4 23840100 1753630 Positive_regulation MMP28 NOX5 23840100 1753627 Positive_regulation MMP28 NPR1 24885858 3226733 Positive_regulation MMP28 NR4A1 24851101 1039875 Positive_regulation MMP28 NR4A1 24851101 1039897 Positive_regulation MMP28 NRAS 23028410 2219986 Positive_regulation MMP28 NRAS 23365639 2745211 Positive_regulation MMP28 NUP43 20109185 284122 Positive_regulation MMP28 OPN1SW 16207333 104388 Positive_regulation MMP28 OSM 25057495 195460 Positive_regulation MMP28 P2RY2 25238333 2201302 Positive_regulation MMP28 P2RY2 25238333 2201333 Positive_regulation MMP28 PAK2 20111678 1089056 Positive_regulation MMP28 PAK2 20111678 1089144 Positive_regulation MMP28 PARK7 20186336 2441679 Positive_regulation MMP28 PARP1 22906755 154133 Positive_regulation MMP28 PBRM1 18516228 3041493 Positive_regulation MMP28 PDLIM7 24885469 273274 Positive_regulation MMP28 PECAM1 12591918 1291184 Positive_regulation MMP28 PGF 23805043 1915977 Positive_regulation MMP28 PHB 20856874 2474877 Positive_regulation MMP28 PIK3CA 16551362 249272 Positive_regulation MMP28 PIK3CA 19775453 254232 Positive_regulation MMP28 PIK3CA 23061721 533334 Positive_regulation MMP28 PIK3CA 23383143 2748155 Positive_regulation MMP28 PIK3CA 23797661 1107850 Positive_regulation MMP28 PIK3CA 25147440 1761425 Positive_regulation MMP28 PIK3R1 16551362 249273 Positive_regulation MMP28 PIK3R1 19775453 254233 Positive_regulation MMP28 PIK3R1 23061721 533335 Positive_regulation MMP28 PIK3R1 23383143 2748156 Positive_regulation MMP28 PIK3R1 23797661 1107851 Positive_regulation MMP28 PIK3R1 25147440 1761426 Positive_regulation MMP28 PLAT 23977299 2839942 Positive_regulation MMP28 PLAT 24303218 2003287 Positive_regulation MMP28 PLAU 24189182 787862 Positive_regulation MMP28 PLAU 9083329 446100 Positive_regulation MMP28 PLD1 23752189 2152471 Positive_regulation MMP28 PLD2 23752189 2152472 Positive_regulation MMP28 PLD3 23752189 2152467 Positive_regulation MMP28 PLD4 23752189 2152468 Positive_regulation MMP28 PLD5 23752189 2152469 Positive_regulation MMP28 PLD6 23752189 2152470 Positive_regulation MMP28 PLG 18700005 396147 Positive_regulation MMP28 PLG 20204159 1671968 Positive_regulation MMP28 PLG 22384127 2606280 Positive_regulation MMP28 PLG 22563394 2626190 Positive_regulation MMP28 PLG 23008698 833285 Positive_regulation MMP28 PLG 23724005 2798886 Positive_regulation MMP28 PLG 9083329 446101 Positive_regulation MMP28 PLG 9635853 447165 Positive_regulation MMP28 POLDIP2 12010565 98870 Positive_regulation MMP28 POLDIP2 23663277 1678759 Positive_regulation MMP28 PRDX2 24062615 1628863 Positive_regulation MMP28 PRKAA1 23561047 509519 Positive_regulation MMP28 PRKAA2 23561047 509520 Positive_regulation MMP28 PRKAB1 23561047 509521 Positive_regulation MMP28 PRKAB2 23561047 509522 Positive_regulation MMP28 PRKAG1 23561047 509523 Positive_regulation MMP28 PRKAG2 23561047 509524 Positive_regulation MMP28 PRKD1 23562655 829739 Positive_regulation MMP28 PROL1 25220640 19711 Positive_regulation MMP28 PTGER4 22570740 2631790 Positive_regulation MMP28 PTGS2 15482602 668279 Positive_regulation MMP28 PTGS2 20169190 3046283 Positive_regulation MMP28 PTGS2 21457581 3178044 Positive_regulation MMP28 PTGS2 23270317 412339 Positive_regulation MMP28 PTGS2 24817792 1758481 Positive_regulation MMP28 PTP4A3 25220640 19712 Positive_regulation MMP28 PTPRC 18779349 1551950 Positive_regulation MMP28 RALA 21179550 2489007 Positive_regulation MMP28 RANBP9 23348590 559320 Positive_regulation MMP28 RASGRF1 19678938 116409 Positive_regulation MMP28 RASGRF1 19678938 116410 Positive_regulation MMP28 RBBP4 21143861 379626 Positive_regulation MMP28 RBBP4 24062615 1628643 Positive_regulation MMP28 RBBP7 21143861 379627 Positive_regulation MMP28 RBBP7 24062615 1628644 Positive_regulation MMP28 RBPJ 24971735 612509 Positive_regulation MMP28 RELA 15770046 1739810 Positive_regulation MMP28 RELA 22570691 2631211 Positive_regulation MMP28 RELA 23226337 2724146 Positive_regulation MMP28 RELA 23482348 2182541 Positive_regulation MMP28 RHOA 16552434 427249 Positive_regulation MMP28 RLN1 15642129 101949 Positive_regulation MMP28 RLN1 22936987 2682186 Positive_regulation MMP28 RLN1 22936987 2682187 Positive_regulation MMP28 RLN1 22936987 2682543 Positive_regulation MMP28 RLN2 15642129 101950 Positive_regulation MMP28 RLN2 22936987 2682188 Positive_regulation MMP28 RLN2 22936987 2682189 Positive_regulation MMP28 RLN2 22936987 2682544 Positive_regulation MMP28 RLN3 15642129 101951 Positive_regulation MMP28 RLN3 22936987 2682190 Positive_regulation MMP28 RLN3 22936987 2682191 Positive_regulation MMP28 RLN3 22936987 2682545 Positive_regulation MMP28 RNF19A 22570668 634489 Positive_regulation MMP28 RUNX2 19915614 2128182 Positive_regulation MMP28 S100A12 23638054 2787394 Positive_regulation MMP28 S100A4 20442771 2448888 Positive_regulation MMP28 S100A4 22782346 438975 Positive_regulation MMP28 SERPINF1 22690122 1224335 Positive_regulation MMP28 SETD2 21843314 1505498 Positive_regulation MMP28 SETD2 21847402 1238182 Positive_regulation MMP28 SFN 23662110 818750 Positive_regulation MMP28 SIRT1 20920189 3110934 Positive_regulation MMP28 SLC17A5 25215580 1484933 Positive_regulation MMP28 SLC22A3 21843314 1505497 Positive_regulation MMP28 SLC9A1 PMC2756345 496281 Positive_regulation MMP28 SNAP25 23028481 2691035 Positive_regulation MMP28 SP1 24755270 272764 Positive_regulation MMP28 SPARC 21192846 623525 Positive_regulation MMP28 SPARC 25147739 413717 Positive_regulation MMP28 SPARC 25147739 413769 Positive_regulation MMP28 SPN 25414930 177649 Positive_regulation MMP28 SPP1 24944898 1887941 Positive_regulation MMP28 SRC 20167811 2007798 Positive_regulation MMP28 SRC 24319683 185584 Positive_regulation MMP28 SSFA2 7537277 1436581 Positive_regulation MMP28 SSFA2 7537277 1436626 Positive_regulation MMP28 STAT3 23820254 441067 Positive_regulation MMP28 STAT3 23820254 441068 Positive_regulation MMP28 STAT3 23820254 441160 Positive_regulation MMP28 STAT3 25143751 645527 Positive_regulation MMP28 STS 22937143 2683063 Positive_regulation MMP28 SYT1 24755270 272765 Positive_regulation MMP28 TAGLN 25050546 2990964 Positive_regulation MMP28 TAT 22419111 555169 Positive_regulation MMP28 TAT 22419111 555198 Positive_regulation MMP28 TAT 24359561 3216112 Positive_regulation MMP28 TBX22 12756268 1527056 Positive_regulation MMP28 TBX22 12756268 1527057 Positive_regulation MMP28 TBX22 12756268 1527097 Positive_regulation MMP28 TBX22 12756268 1527129 Positive_regulation MMP28 TBX22 12756268 1527130 Positive_regulation MMP28 TBX22 12756268 1527281 Positive_regulation MMP28 TBX22 12756268 1527282 Positive_regulation MMP28 TBX22 12756268 1527343 Positive_regulation MMP28 TBX22 12756268 1527387 Positive_regulation MMP28 TCEA1 12975354 1297285 Positive_regulation MMP28 TCF12 19924227 2431148 Positive_regulation MMP28 TCF12 24926361 844286 Positive_regulation MMP28 TCF12 24971028 1629005 Positive_regulation MMP28 TCF12 25029110 2989517 Positive_regulation MMP28 TCF15 19924227 2431149 Positive_regulation MMP28 TCF15 24926361 844287 Positive_regulation MMP28 TCF15 24971028 1629006 Positive_regulation MMP28 TCF15 25029110 2989518 Positive_regulation MMP28 TCF19 19924227 2431150 Positive_regulation MMP28 TCF19 24926361 844288 Positive_regulation MMP28 TCF19 24971028 1629007 Positive_regulation MMP28 TCF19 25029110 2989519 Positive_regulation MMP28 TCF20 19924227 2431151 Positive_regulation MMP28 TCF20 24926361 844289 Positive_regulation MMP28 TCF20 24971028 1629008 Positive_regulation MMP28 TCF20 25029110 2989520 Positive_regulation MMP28 TCF21 19924227 2431152 Positive_regulation MMP28 TCF21 24926361 844290 Positive_regulation MMP28 TCF21 24971028 1629009 Positive_regulation MMP28 TCF21 25029110 2989521 Positive_regulation MMP28 TCF23 19924227 2431156 Positive_regulation MMP28 TCF23 24926361 844295 Positive_regulation MMP28 TCF23 24971028 1629013 Positive_regulation MMP28 TCF23 25029110 2989525 Positive_regulation MMP28 TCF24 19924227 2431158 Positive_regulation MMP28 TCF24 24926361 844297 Positive_regulation MMP28 TCF24 24971028 1629015 Positive_regulation MMP28 TCF24 25029110 2989527 Positive_regulation MMP28 TCF25 19924227 2431157 Positive_regulation MMP28 TCF25 24926361 844296 Positive_regulation MMP28 TCF25 24971028 1629014 Positive_regulation MMP28 TCF25 25029110 2989526 Positive_regulation MMP28 TCF3 19924227 2431153 Positive_regulation MMP28 TCF3 24926361 844291 Positive_regulation MMP28 TCF3 24971028 1629010 Positive_regulation MMP28 TCF3 25029110 2989522 Positive_regulation MMP28 TCF4 19924227 2431154 Positive_regulation MMP28 TCF4 24926361 844292 Positive_regulation MMP28 TCF4 24971028 1629011 Positive_regulation MMP28 TCF4 25029110 2989523 Positive_regulation MMP28 TCF7 19924227 2431155 Positive_regulation MMP28 TCF7 24926361 844293 Positive_regulation MMP28 TCF7 24971028 1629012 Positive_regulation MMP28 TCF7 25029110 2989524 Positive_regulation MMP28 TERT 24388106 222480 Positive_regulation MMP28 TFPI2 23905012 853445 Positive_regulation MMP28 TFPI2 PMC2756345 496056 Positive_regulation MMP28 TGFB1I1 24811612 1159548 Positive_regulation MMP28 TGFB2 22815623 1914649 Positive_regulation MMP28 TGM2 24130925 204503 Positive_regulation MMP28 THBS1 11980922 1282479 Positive_regulation MMP28 THBS1 11980922 1282480 Positive_regulation MMP28 THBS1 11980922 1282561 Positive_regulation MMP28 THBS1 21423603 2508095 Positive_regulation MMP28 THBS2 11980922 1282481 Positive_regulation MMP28 TIMP1 12975354 1297286 Positive_regulation MMP28 TIMP1 20012240 495685 Positive_regulation MMP28 TIMP1 22911824 2676954 Positive_regulation MMP28 TIMP1 23187000 219732 Positive_regulation MMP28 TIMP1 23304261 2225382 Positive_regulation MMP28 TIMP1 23715597 1886186 Positive_regulation MMP28 TIMP1 24766991 1675778 Positive_regulation MMP28 TIMP1 24860785 947882 Positive_regulation MMP28 TIMP2 21861887 3112509 Positive_regulation MMP28 TIMP2 22911824 2676955 Positive_regulation MMP28 TIMP2 24231999 1137919 Positive_regulation MMP28 TIMP2 24766991 1675808 Positive_regulation MMP28 TLR1 17129374 107205 Positive_regulation MMP28 TLR1 23940584 2831661 Positive_regulation MMP28 TLR10 17129374 107213 Positive_regulation MMP28 TLR10 23940584 2831669 Positive_regulation MMP28 TLR2 17129374 107206 Positive_regulation MMP28 TLR2 20652007 1747500 Positive_regulation MMP28 TLR2 23940584 2831662 Positive_regulation MMP28 TLR3 17129374 107207 Positive_regulation MMP28 TLR3 23940584 2831663 Positive_regulation MMP28 TLR4 17129374 107208 Positive_regulation MMP28 TLR4 23940584 2831664 Positive_regulation MMP28 TLR5 17129374 107209 Positive_regulation MMP28 TLR5 23940584 2831665 Positive_regulation MMP28 TLR6 17129374 107214 Positive_regulation MMP28 TLR6 23940584 2831670 Positive_regulation MMP28 TLR7 17129374 107210 Positive_regulation MMP28 TLR7 23940584 2831666 Positive_regulation MMP28 TLR8 17129374 107211 Positive_regulation MMP28 TLR8 23940584 2831667 Positive_regulation MMP28 TLR9 17129374 107212 Positive_regulation MMP28 TLR9 23940584 2831668 Positive_regulation MMP28 TLR9 24959259 2168834 Positive_regulation MMP28 TLR9 24959259 2168835 Positive_regulation MMP28 TMED7 23785669 945516 Positive_regulation MMP28 TNC 21818551 600138 Positive_regulation MMP28 TNF 14979937 100160 Positive_regulation MMP28 TNF 15987479 103891 Positive_regulation MMP28 TNF 17118171 3096351 Positive_regulation MMP28 TNF 18237379 379284 Positive_regulation MMP28 TNF 19226472 112814 Positive_regulation MMP28 TNF 19281072 1071664 Positive_regulation MMP28 TNF 19435506 113257 Positive_regulation MMP28 TNF 19889233 3097665 Positive_regulation MMP28 TNF 20126546 2439113 Positive_regulation MMP28 TNF 20126546 2439160 Positive_regulation MMP28 TNF 20543948 2452477 Positive_regulation MMP28 TNF 20871770 1047096 Positive_regulation MMP28 TNF 21615884 259870 Positive_regulation MMP28 TNF 21801383 1652103 Positive_regulation MMP28 TNF 21912722 2223876 Positive_regulation MMP28 TNF 22005011 1697936 Positive_regulation MMP28 TNF 22315682 1687075 Positive_regulation MMP28 TNF 22778767 636633 Positive_regulation MMP28 TNF 23441116 1915726 Positive_regulation MMP28 TNF 23533687 2225596 Positive_regulation MMP28 TNF 23924945 1109770 Positive_regulation MMP28 TNF 24236107 2878528 Positive_regulation MMP28 TNF 24278882 1498593 Positive_regulation MMP28 TNF 24762063 401029 Positive_regulation MMP28 TNF 24926361 844294 Positive_regulation MMP28 TNF 24977073 1154285 Positive_regulation MMP28 TNF 25143751 645528 Positive_regulation MMP28 TNF 25147435 1761203 Positive_regulation MMP28 TNF 25250141 1148957 Positive_regulation MMP28 TNF 25356505 1132728 Positive_regulation MMP28 TNFRSF11B 23340891 730006 Positive_regulation MMP28 TP53 18516228 3041370 Positive_regulation MMP28 TRNAE1 20418905 2129603 Positive_regulation MMP28 TRNAE1 20418905 2129604 Positive_regulation MMP28 TRNAE1 20418905 2129605 Positive_regulation MMP28 TRNAE1 20418905 2129606 Positive_regulation MMP28 TRNAE1 20418905 2131057 Positive_regulation MMP28 TRPV1 25205949 90051 Positive_regulation MMP28 TSPAN1 23840773 2816982 Positive_regulation MMP28 TSPAN10 23840773 2816991 Positive_regulation MMP28 TSPAN11 23840773 2816993 Positive_regulation MMP28 TSPAN12 23840773 2816986 Positive_regulation MMP28 TSPAN13 23840773 2816987 Positive_regulation MMP28 TSPAN14 23840773 2816989 Positive_regulation MMP28 TSPAN15 23840773 2816988 Positive_regulation MMP28 TSPAN16 23840773 2816992 Positive_regulation MMP28 TSPAN17 23840773 2816979 Positive_regulation MMP28 TSPAN18 23840773 2816984 Positive_regulation MMP28 TSPAN19 23840773 2816994 Positive_regulation MMP28 TSPAN2 23840773 2816983 Positive_regulation MMP28 TSPAN3 23840773 2816980 Positive_regulation MMP28 TSPAN31 23840773 2816973 Positive_regulation MMP28 TSPAN32 23840773 2816978 Positive_regulation MMP28 TSPAN33 23840773 2816990 Positive_regulation MMP28 TSPAN4 23840773 2816977 Positive_regulation MMP28 TSPAN5 23840773 2816981 Positive_regulation MMP28 TSPAN6 23840773 2816976 Positive_regulation MMP28 TSPAN7 23840773 2816974 Positive_regulation MMP28 TSPAN8 23840773 2816975 Positive_regulation MMP28 TSPAN9 23840773 2816985 Positive_regulation MMP28 TWIST1 22891766 245247 Positive_regulation MMP28 UCP2 17472436 2262909 Positive_regulation MMP28 UCP2 17472436 2262975 Positive_regulation MMP28 UCP2 23210978 3188316 Positive_regulation MMP28 USP1 20418905 2131058 Positive_regulation MMP28 USP10 20418905 2131059 Positive_regulation MMP28 USP11 20418905 2131060 Positive_regulation MMP28 USP12 20418905 2131103 Positive_regulation MMP28 USP13 20418905 2131061 Positive_regulation MMP28 USP14 20418905 2131062 Positive_regulation MMP28 USP15 20418905 2131063 Positive_regulation MMP28 USP16 20418905 2131064 Positive_regulation MMP28 USP18 20418905 2131065 Positive_regulation MMP28 USP19 20418905 2131066 Positive_regulation MMP28 USP2 20418905 2131067 Positive_regulation MMP28 USP20 20418905 2131068 Positive_regulation MMP28 USP21 20418905 2131069 Positive_regulation MMP28 USP22 20418905 2131070 Positive_regulation MMP28 USP24 20418905 2131071 Positive_regulation MMP28 USP25 20418905 2131072 Positive_regulation MMP28 USP26 20418905 2131080 Positive_regulation MMP28 USP28 20418905 2131073 Positive_regulation MMP28 USP29 20418905 2131082 Positive_regulation MMP28 USP3 20418905 2131074 Positive_regulation MMP28 USP30 20418905 2131090 Positive_regulation MMP28 USP31 20418905 2131085 Positive_regulation MMP28 USP32 20418905 2131083 Positive_regulation MMP28 USP33 20418905 2131084 Positive_regulation MMP28 USP34 20418905 2131091 Positive_regulation MMP28 USP35 20418905 2131086 Positive_regulation MMP28 USP36 20418905 2131087 Positive_regulation MMP28 USP37 20418905 2131088 Positive_regulation MMP28 USP38 20418905 2131092 Positive_regulation MMP28 USP39 20418905 2131096 Positive_regulation MMP28 USP4 20418905 2131075 Positive_regulation MMP28 USP40 20418905 2131094 Positive_regulation MMP28 USP41 20418905 2131095 Positive_regulation MMP28 USP42 20418905 2131093 Positive_regulation MMP28 USP43 20418905 2131097 Positive_regulation MMP28 USP44 20418905 2131089 Positive_regulation MMP28 USP45 20418905 2131102 Positive_regulation MMP28 USP46 20418905 2131098 Positive_regulation MMP28 USP47 20418905 2131099 Positive_regulation MMP28 USP48 20418905 2131081 Positive_regulation MMP28 USP49 20418905 2131100 Positive_regulation MMP28 USP5 20418905 2131076 Positive_regulation MMP28 USP50 20418905 2131101 Positive_regulation MMP28 USP51 20418905 2131104 Positive_regulation MMP28 USP53 20418905 2131106 Positive_regulation MMP28 USP54 20418905 2131105 Positive_regulation MMP28 USP6 20418905 2131077 Positive_regulation MMP28 USP7 20418905 2131078 Positive_regulation MMP28 USP8 20418905 2131079 Positive_regulation MMP28 UTRN 22438978 2612479 Positive_regulation MMP28 VCAM1 25525444 827393 Positive_regulation MMP28 VEGFA 19375502 1731650 Positive_regulation MMP28 VEGFA 21193734 716985 Positive_regulation MMP28 VEGFA 21349159 3206853 Positive_regulation MMP28 VEGFA 21349159 3207050 Positive_regulation MMP28 VEGFA 21559216 3128163 Positive_regulation MMP28 VEGFA 22044497 3165499 Positive_regulation MMP28 VEGFA 22206448 6646 Positive_regulation MMP28 VEGFA 23161900 91189 Positive_regulation MMP28 VEGFA 23552472 1506815 Positive_regulation MMP28 VEGFA 24641672 3114507 Positive_regulation MMP28 VEGFA 25257525 1131077 Positive_regulation MMP28 VEGFA 8554978 445126 Positive_regulation MMP28 VNN1 22720042 2654267 Positive_regulation MMP28 WISP2 14636425 523446 Positive_regulation MMP28 WNT1 16438732 3106119 Positive_regulation MMP28 WNT1 23965253 129129 Positive_regulation MMP28 WNT1 23965253 129457 Positive_regulation MMP28 WNT1 25360795 3021467 Positive_regulation MMP28 WNT11 16438732 3106120 Positive_regulation MMP28 WNT11 23965253 129130 Positive_regulation MMP28 WNT11 23965253 129458 Positive_regulation MMP28 WNT11 25360795 3021468 Positive_regulation MMP28 WNT16 16438732 3106125 Positive_regulation MMP28 WNT16 23965253 129135 Positive_regulation MMP28 WNT16 23965253 129463 Positive_regulation MMP28 WNT16 25360795 3021473 Positive_regulation MMP28 WNT2 16438732 3106121 Positive_regulation MMP28 WNT2 23965253 129131 Positive_regulation MMP28 WNT2 23965253 129459 Positive_regulation MMP28 WNT2 25360795 3021469 Positive_regulation MMP28 WNT3 16438732 3106122 Positive_regulation MMP28 WNT3 23965253 129132 Positive_regulation MMP28 WNT3 23965253 129460 Positive_regulation MMP28 WNT3 25360795 3021470 Positive_regulation MMP28 WNT3A 24479426 131484 Positive_regulation MMP28 WNT4 16438732 3106123 Positive_regulation MMP28 WNT4 23965253 129133 Positive_regulation MMP28 WNT4 23965253 129461 Positive_regulation MMP28 WNT4 25360795 3021471 Positive_regulation MMP28 WNT5A 23484019 2765091 Positive_regulation MMP28 WNT5A 24757147 135774 Positive_regulation MMP28 WNT6 16438732 3106124 Positive_regulation MMP28 WNT6 23965253 129134 Positive_regulation MMP28 WNT6 23965253 129462 Positive_regulation MMP28 WNT6 25360795 3021472 Positive_regulation MMP28 WNT7A 24479426 131483 Positive_regulation MMP28 XIAP 24336521 1819994 Positive_regulation MMP3 AGR2 17129374 107133 Positive_regulation MMP3 AGR2 17129374 107134 Positive_regulation MMP3 ALOX5 22022214 1084186 Positive_regulation MMP3 CAPN8 18493299 2389148 Positive_regulation MMP3 CAPN8 21911754 720251 Positive_regulation MMP3 CCND1 22942717 1097101 Positive_regulation MMP3 CTGF 25003330 2195010 Positive_regulation MMP3 EPHB2 18629305 793174 Positive_regulation MMP3 EPHB2 19161638 252273 Positive_regulation MMP3 EPHB2 21738525 922810 Positive_regulation MMP3 EPHB2 22114952 1229909 Positive_regulation MMP3 EPHB2 22310287 2146214 Positive_regulation MMP3 EPHB2 23548063 367086 Positive_regulation MMP3 EPHB2 23663277 1678788 Positive_regulation MMP3 EPHB2 23671446 95675 Positive_regulation MMP3 EPHB2 24084727 1113157 Positive_regulation MMP3 GPNMB 20711474 2471238 Positive_regulation MMP3 GPR115 24066041 2850392 Positive_regulation MMP3 GPR132 24066041 2850381 Positive_regulation MMP3 GPR87 24066041 2850461 Positive_regulation MMP3 HBEGF 21179550 2489219 Positive_regulation MMP3 IL1B 11132772 1737236 Positive_regulation MMP3 IL1B 15203568 1739675 Positive_regulation MMP3 IL1B 23613752 2782098 Positive_regulation MMP3 MAP2K6 20667128 1857632 Positive_regulation MMP3 MIP 21347304 2503610 Positive_regulation MMP3 MMP28 PMC4062143 99613 Positive_regulation MMP3 MMP7 21455784 2012504 Positive_regulation MMP3 MMP7 25352733 1917304 Positive_regulation MMP3 MMP7 PMC4062143 99628 Positive_regulation MMP3 MUC16 23694968 3135801 Positive_regulation MMP3 PECAM1 12591918 1291198 Positive_regulation MMP3 PLAT 23565108 935253 Positive_regulation MMP3 PLAT 23565108 935268 Positive_regulation MMP3 PLAT 23565108 935273 Positive_regulation MMP3 PLAT 23565108 935330 Positive_regulation MMP3 PLAT 23565108 935331 Positive_regulation MMP3 PLAT 23565108 935332 Positive_regulation MMP3 PLAT 23565108 935339 Positive_regulation MMP3 PLAT 23565108 935342 Positive_regulation MMP3 PLAT 23977299 2839956 Positive_regulation MMP3 PLAT 24303218 2003301 Positive_regulation MMP3 PLAU 24189182 787876 Positive_regulation MMP3 PLAU 9083329 446128 Positive_regulation MMP3 TFPI2 23905012 853459 Positive_regulation MMP3 TFPI2 PMC2756345 496096 Positive_regulation MMP3 TGM2 24130925 204517 Positive_regulation MMP3 TLR7 17129374 107350 Positive_regulation MMP3 TLR7 23940584 2831806 Positive_regulation MMP3 TLR7 24409325 2906919 Positive_regulation MMP3 TNF 11132772 1737227 Positive_regulation MMP3 TNF 14979937 100174 Positive_regulation MMP3 TNF 15987479 103874 Positive_regulation MMP3 TNF 15987479 103919 Positive_regulation MMP3 TNF 16277688 104761 Positive_regulation MMP3 TNF 17118171 3096365 Positive_regulation MMP3 TNF 18237379 379298 Positive_regulation MMP3 TNF 19226472 112876 Positive_regulation MMP3 TNF 19226472 112893 Positive_regulation MMP3 TNF 19281072 1071679 Positive_regulation MMP3 TNF 19435506 113273 Positive_regulation MMP3 TNF 19461876 3043841 Positive_regulation MMP3 TNF 19889233 3097679 Positive_regulation MMP3 TNF 20126546 2439127 Positive_regulation MMP3 TNF 20126546 2439174 Positive_regulation MMP3 TNF 20543948 2452505 Positive_regulation MMP3 TNF 20836843 120094 Positive_regulation MMP3 TNF 20871770 1047110 Positive_regulation MMP3 TNF 21345249 121581 Positive_regulation MMP3 TNF 21912722 2223890 Positive_regulation MMP3 TNF 22005011 1697950 Positive_regulation MMP3 TNF 22315682 1687135 Positive_regulation MMP3 TNF 22500233 154796 Positive_regulation MMP3 TNF 22623923 900934 Positive_regulation MMP3 TNF 22778767 636647 Positive_regulation MMP3 TNF 23072510 127029 Positive_regulation MMP3 TNF 23441116 1915740 Positive_regulation MMP3 TNF 23533687 2225610 Positive_regulation MMP3 TNF 23924945 1109786 Positive_regulation MMP3 TNF 24062615 1628849 Positive_regulation MMP3 TNF 24062615 1628877 Positive_regulation MMP3 TNF 24062615 1628897 Positive_regulation MMP3 TNF 24116286 204333 Positive_regulation MMP3 TNF 24236107 2878556 Positive_regulation MMP3 TNF 24278882 1498607 Positive_regulation MMP3 TNF 24284399 1121770 Positive_regulation MMP3 TNF 24284399 1121776 Positive_regulation MMP3 TNF 24349530 2898417 Positive_regulation MMP3 TNF 24349530 2898421 Positive_regulation MMP3 TNF 24349530 2898426 Positive_regulation MMP3 TNF 24349530 2898431 Positive_regulation MMP3 TNF 24349530 2898432 Positive_regulation MMP3 TNF 24349530 2898440 Positive_regulation MMP3 TNF 24349530 2898446 Positive_regulation MMP3 TNF 24552146 295833 Positive_regulation MMP3 TNF 24762063 401043 Positive_regulation MMP3 TNF 24926361 844465 Positive_regulation MMP3 TNF 24977073 1154330 Positive_regulation MMP3 TNF 25143751 645570 Positive_regulation MMP3 TNF 25147435 1761217 Positive_regulation MMP3 TNF 25250141 1148971 Positive_regulation MMP3 TNF 25332857 3165812 Positive_regulation MMP3 TNF 25356505 1133367 Positive_regulation MMP3 TP63 19465391 2046324 Positive_regulation MMP3 TP63 19465391 2046325 Positive_regulation MMP3 TSPAN1 23840773 2817290 Positive_regulation MMP3 WNT7A 24479426 131530 Positive_regulation MMP3 WNT7A 24479426 131594 Positive_regulation MMP3 WNT7A 24479426 131672 Positive_regulation MMP7 ACE 21887284 2549143 Positive_regulation MMP7 ADAM10 24244825 205970 Positive_regulation MMP7 ADAM11 24244825 205971 Positive_regulation MMP7 ADAM12 24244825 205972 Positive_regulation MMP7 ADAM15 24244825 205973 Positive_regulation MMP7 ADAM17 18046869 1071384 Positive_regulation MMP7 ADAM17 24244825 205974 Positive_regulation MMP7 ADAM18 24244825 205975 Positive_regulation MMP7 ADAM19 24244825 205976 Positive_regulation MMP7 ADAM2 24244825 205977 Positive_regulation MMP7 ADAM20 24244825 205978 Positive_regulation MMP7 ADAM21 24244825 205979 Positive_regulation MMP7 ADAM22 24244825 205980 Positive_regulation MMP7 ADAM23 24244825 205981 Positive_regulation MMP7 ADAM28 24244825 205982 Positive_regulation MMP7 ADAM29 24244825 205983 Positive_regulation MMP7 ADAM30 24244825 205984 Positive_regulation MMP7 ADAM32 24244825 205969 Positive_regulation MMP7 ADAM33 24244825 205968 Positive_regulation MMP7 ADAM5 24244825 205985 Positive_regulation MMP7 ADAM6 24244825 205986 Positive_regulation MMP7 ADAM7 24244825 205987 Positive_regulation MMP7 ADAM8 24244825 205988 Positive_regulation MMP7 ADAM9 24244825 205989 Positive_regulation MMP7 ADCY1 23249435 399155 Positive_regulation MMP7 ADCY10 23249435 399154 Positive_regulation MMP7 ADCY2 23249435 399156 Positive_regulation MMP7 ADCY3 23249435 399157 Positive_regulation MMP7 ADCY4 23249435 399158 Positive_regulation MMP7 ADCY5 23249435 399159 Positive_regulation MMP7 ADCY6 23249435 399160 Positive_regulation MMP7 ADCY7 23249435 399161 Positive_regulation MMP7 ADCY8 23249435 399162 Positive_regulation MMP7 ADCY9 23249435 399163 Positive_regulation MMP7 ADIPOQ 21194467 121316 Positive_regulation MMP7 ADIPOQ 21194467 121340 Positive_regulation MMP7 ADIPOQ 24434628 840340 Positive_regulation MMP7 ADIPOQ 24667577 2938867 Positive_regulation MMP7 AGR2 17129374 107137 Positive_regulation MMP7 AGR2 17129374 107138 Positive_regulation MMP7 AGR3 17129374 107135 Positive_regulation MMP7 AGR3 17129374 107136 Positive_regulation MMP7 AHR 22500183 1156087 Positive_regulation MMP7 AKT1 23061721 533414 Positive_regulation MMP7 AKT1 23383143 2748233 Positive_regulation MMP7 AKT1 23797661 1107937 Positive_regulation MMP7 AKT1 25036034 1128548 Positive_regulation MMP7 AKT1 25147440 1761504 Positive_regulation MMP7 AKT2 23061721 533415 Positive_regulation MMP7 AKT2 23383143 2748234 Positive_regulation MMP7 AKT2 23797661 1107938 Positive_regulation MMP7 AKT2 25036034 1128549 Positive_regulation MMP7 AKT2 25147440 1761505 Positive_regulation MMP7 AKT3 23061721 533416 Positive_regulation MMP7 AKT3 23383143 2748235 Positive_regulation MMP7 AKT3 23797661 1107939 Positive_regulation MMP7 AKT3 25036034 1128550 Positive_regulation MMP7 AKT3 25147440 1761506 Positive_regulation MMP7 ANGPT2 18493299 2389215 Positive_regulation MMP7 ANGPT2 23161900 91244 Positive_regulation MMP7 ANGPT2 24811612 1159639 Positive_regulation MMP7 ANXA2 24884814 273102 Positive_regulation MMP7 APOB 17714581 507714 Positive_regulation MMP7 ARCN1 18447576 2369381 Positive_regulation MMP7 AREG 25147440 1761721 Positive_regulation MMP7 ARG1 19405959 463891 Positive_regulation MMP7 ARG2 19405959 463892 Positive_regulation MMP7 ASCL1 23300791 2735973 Positive_regulation MMP7 ASCL1 23300791 2735974 Positive_regulation MMP7 ASCL1 23300791 2735981 Positive_regulation MMP7 ASCL1 23300791 2735990 Positive_regulation MMP7 ASIP 19405959 463893 Positive_regulation MMP7 ATF4 25078779 2993659 Positive_regulation MMP7 AWAT2 PMC2938647 3157381 Positive_regulation MMP7 BAX 12756268 1527176 Positive_regulation MMP7 BAX 12756268 1527248 Positive_regulation MMP7 BAX 12925707 1295668 Positive_regulation MMP7 BAX 18516228 3041447 Positive_regulation MMP7 BAX 21347304 2503575 Positive_regulation MMP7 BAX 21654827 552284 Positive_regulation MMP7 BAX 22419111 555229 Positive_regulation MMP7 BAX 22550588 154896 Positive_regulation MMP7 BAX 24705500 1730693 Positive_regulation MMP7 BAX 24959718 2983134 Positive_regulation MMP7 BAX 25278781 1478840 Positive_regulation MMP7 BCL10 23437193 2756133 Positive_regulation MMP7 BCL2 11181702 1518671 Positive_regulation MMP7 BCL2 20043854 402236 Positive_regulation MMP7 BCL2 22458888 3084458 Positive_regulation MMP7 BCL2 23437193 2756134 Positive_regulation MMP7 BCL2 24808916 825812 Positive_regulation MMP7 BCL2 24808916 825890 Positive_regulation MMP7 BCL3 23437193 2756135 Positive_regulation MMP7 BCL5 23437193 2756130 Positive_regulation MMP7 BCL6 23437193 2756131 Positive_regulation MMP7 BCL9 23437193 2756132 Positive_regulation MMP7 BDKRB1 21729302 3101294 Positive_regulation MMP7 BDKRB2 21729302 3101295 Positive_regulation MMP7 BMP4 24053318 269723 Positive_regulation MMP7 BNIP3 22292033 2592054 Positive_regulation MMP7 BRMS1 24879377 2975630 Positive_regulation MMP7 BSG 16207318 104120 Positive_regulation MMP7 BSG 16207318 104164 Positive_regulation MMP7 BSG 16207318 104186 Positive_regulation MMP7 BSG 18596970 2392439 Positive_regulation MMP7 BSG 19664212 116373 Positive_regulation MMP7 BSG 19775453 254290 Positive_regulation MMP7 BSG 19775453 254291 Positive_regulation MMP7 BSG 20540754 3098468 Positive_regulation MMP7 BSG 20540754 3098512 Positive_regulation MMP7 BSG 20540754 3098534 Positive_regulation MMP7 BSG 20540754 3098556 Positive_regulation MMP7 BSG 21762534 260596 Positive_regulation MMP7 BSG 22480370 1661469 Positive_regulation MMP7 BSG 22782346 439006 Positive_regulation MMP7 BSG 23167819 1626759 Positive_regulation MMP7 BSG 23922889 2827301 Positive_regulation MMP7 BSG 23922889 2827302 Positive_regulation MMP7 BSG 24281180 502103 Positive_regulation MMP7 BSG 24281180 502147 Positive_regulation MMP7 BSG 24739808 1126169 Positive_regulation MMP7 BSG 25076423 2993267 Positive_regulation MMP7 BSG 25076423 2993268 Positive_regulation MMP7 BSG 25268615 1131369 Positive_regulation MMP7 BSG 25268615 1131458 Positive_regulation MMP7 BSG 25404518 133865 Positive_regulation MMP7 BST1 22916288 2680669 Positive_regulation MMP7 C4BPA 25115920 2996523 Positive_regulation MMP7 CA2 18516228 3041349 Positive_regulation MMP7 CA2 22536507 154871 Positive_regulation MMP7 CA2 23233904 941667 Positive_regulation MMP7 CA2 24739681 3210957 Positive_regulation MMP7 CA2 24739681 3210979 Positive_regulation MMP7 CALM3 19636377 2421977 Positive_regulation MMP7 CAPN1 18493299 2389154 Positive_regulation MMP7 CAPN1 21911754 720258 Positive_regulation MMP7 CAPN10 18493299 2389155 Positive_regulation MMP7 CAPN10 21911754 720259 Positive_regulation MMP7 CAPN11 18493299 2389156 Positive_regulation MMP7 CAPN11 21911754 720260 Positive_regulation MMP7 CAPN12 18493299 2389153 Positive_regulation MMP7 CAPN12 21911754 720257 Positive_regulation MMP7 CAPN13 18493299 2389164 Positive_regulation MMP7 CAPN13 21911754 720269 Positive_regulation MMP7 CAPN14 18493299 2389165 Positive_regulation MMP7 CAPN14 21911754 720270 Positive_regulation MMP7 CAPN15 18493299 2389152 Positive_regulation MMP7 CAPN15 21911754 720256 Positive_regulation MMP7 CAPN2 18493299 2389157 Positive_regulation MMP7 CAPN2 21911754 720261 Positive_regulation MMP7 CAPN3 18493299 2389158 Positive_regulation MMP7 CAPN3 21911754 720262 Positive_regulation MMP7 CAPN5 18493299 2389159 Positive_regulation MMP7 CAPN5 21911754 720263 Positive_regulation MMP7 CAPN6 18493299 2389160 Positive_regulation MMP7 CAPN6 21911754 720264 Positive_regulation MMP7 CAPN7 18493299 2389161 Positive_regulation MMP7 CAPN7 21911754 720265 Positive_regulation MMP7 CAPN8 18493299 2389162 Positive_regulation MMP7 CAPN8 21911754 720266 Positive_regulation MMP7 CAPN9 18493299 2389163 Positive_regulation MMP7 CAPN9 21911754 720267 Positive_regulation MMP7 CASP3 18629305 793175 Positive_regulation MMP7 CASP3 19468318 1088297 Positive_regulation MMP7 CASP3 19468318 1088344 Positive_regulation MMP7 CASP3 19966836 8483 Positive_regulation MMP7 CASP3 20111678 1089107 Positive_regulation MMP7 CASP3 20111678 1089195 Positive_regulation MMP7 CASP3 21423690 812459 Positive_regulation MMP7 CASP3 21595920 1697354 Positive_regulation MMP7 CASP3 22140470 2574797 Positive_regulation MMP7 CASP3 23202971 1098982 Positive_regulation MMP7 CASP3 23552194 294328 Positive_regulation MMP7 CASP3 23667640 2790880 Positive_regulation MMP7 CASP3 24324518 824515 Positive_regulation MMP7 CASP3 25401052 692028 Positive_regulation MMP7 CASP3 PMC3871853 1136474 Positive_regulation MMP7 CASP8 23752353 1729880 Positive_regulation MMP7 CASP8 24324518 824516 Positive_regulation MMP7 CASP8 24705500 1730691 Positive_regulation MMP7 CASP9 18629305 793176 Positive_regulation MMP7 CASP9 19468318 1088298 Positive_regulation MMP7 CASP9 19468318 1088345 Positive_regulation MMP7 CASP9 23752353 1729881 Positive_regulation MMP7 CASP9 24705500 1730692 Positive_regulation MMP7 CASP9 24959718 2983180 Positive_regulation MMP7 CASP9 PMC3871853 1136475 Positive_regulation MMP7 CAST 21911754 720268 Positive_regulation MMP7 CAV1 18596970 2392390 Positive_regulation MMP7 CAV1 22842734 15810 Positive_regulation MMP7 CAV1 23922889 2827303 Positive_regulation MMP7 CCL2 20604932 119437 Positive_regulation MMP7 CCL25 20649989 3226126 Positive_regulation MMP7 CCL4 22013489 813353 Positive_regulation MMP7 CCL4 22872786 178252 Positive_regulation MMP7 CCL5 20604932 119438 Positive_regulation MMP7 CCL5 20604932 119492 Positive_regulation MMP7 CCND1 22942717 1097102 Positive_regulation MMP7 CCR7 19363519 7287 Positive_regulation MMP7 CCR7 19363519 7401 Positive_regulation MMP7 CCR9 20649989 3226171 Positive_regulation MMP7 CD2 18629305 793365 Positive_regulation MMP7 CD24 PMC2756345 496099 Positive_regulation MMP7 CD44 16128620 2368490 Positive_regulation MMP7 CD44 21179550 2489220 Positive_regulation MMP7 CD44 21687519 950352 Positive_regulation MMP7 CD9 23840773 2817490 Positive_regulation MMP7 CD9 23840773 2817540 Positive_regulation MMP7 CDH1 15668718 425275 Positive_regulation MMP7 CDH1 20165718 1497209 Positive_regulation MMP7 CDH1 22902510 834890 Positive_regulation MMP7 CDH1 23054081 93213 Positive_regulation MMP7 CDH1 23365639 2745284 Positive_regulation MMP7 CDH1 23698793 3136065 Positive_regulation MMP7 CDK1 18516228 3041419 Positive_regulation MMP7 CDKN2A 24572376 132016 Positive_regulation MMP7 CHRM3 24212649 497906 Positive_regulation MMP7 CLDN6 19920867 1213288 Positive_regulation MMP7 CNGA1 22699690 621484 Positive_regulation MMP7 CNGB1 22699690 621485 Positive_regulation MMP7 CPP 25157203 1605630 Positive_regulation MMP7 CRP 23508642 1710063 Positive_regulation MMP7 CTNNB1 23319034 3129507 Positive_regulation MMP7 CTSB 23936808 182997 Positive_regulation MMP7 CTSK 22046029 739173 Positive_regulation MMP7 CTTN 24531055 503000 Positive_regulation MMP7 CXCL12 22295222 1065031 Positive_regulation MMP7 CXCL12 22675496 2649056 Positive_regulation MMP7 CXCL12 24472670 411704 Positive_regulation MMP7 CXCL13 20412587 1854079 Positive_regulation MMP7 CXCR4 19363519 7354 Positive_regulation MMP7 CXCR4 22295222 1065032 Positive_regulation MMP7 CXCR4 23116176 3215154 Positive_regulation MMP7 CXCR4 24472670 411705 Positive_regulation MMP7 CYCS 15312229 3115344 Positive_regulation MMP7 CYCS 24566142 1124181 Positive_regulation MMP7 CYCS 25505905 23489 Positive_regulation MMP7 DKK1 24325363 1870469 Positive_regulation MMP7 DKK1 24325363 1870471 Positive_regulation MMP7 DST 23110919 1639903 Positive_regulation MMP7 E2F1 25029110 2989986 Positive_regulation MMP7 EARS2 24130267 91498 Positive_regulation MMP7 ECM1 12100737 457431 Positive_regulation MMP7 ECM1 19298660 352722 Positive_regulation MMP7 ECM1 20540754 3098441 Positive_regulation MMP7 ECM1 23840773 2817459 Positive_regulation MMP7 ECM1 8976186 1599689 Positive_regulation MMP7 ECM2 12100737 457432 Positive_regulation MMP7 ECM2 19298660 352723 Positive_regulation MMP7 ECM2 20540754 3098442 Positive_regulation MMP7 ECM2 23840773 2817460 Positive_regulation MMP7 ECM2 8976186 1599690 Positive_regulation MMP7 EDNRA 20953374 506673 Positive_regulation MMP7 EDNRB 20953374 506674 Positive_regulation MMP7 EFEMP2 25255451 3010450 Positive_regulation MMP7 EGF 22627809 834830 Positive_regulation MMP7 EGF 22860018 2670906 Positive_regulation MMP7 EGF 22860018 2671034 Positive_regulation MMP7 EGFR 20667128 1857634 Positive_regulation MMP7 EGFR 21151531 1081417 Positive_regulation MMP7 EGFR 22675459 2648665 Positive_regulation MMP7 EGFR 24362507 502585 Positive_regulation MMP7 EGFR 24872356 2252227 Positive_regulation MMP7 EGFR 24872356 2252272 Positive_regulation MMP7 EGFR 25147440 1761667 Positive_regulation MMP7 EGFR 25356505 1133377 Positive_regulation MMP7 EGFR 25356505 1133378 Positive_regulation MMP7 EGFR 25356505 1133379 Positive_regulation MMP7 EGFR 25356505 1133380 Positive_regulation MMP7 ELK1 23231703 267249 Positive_regulation MMP7 ELL 12975354 1297354 Positive_regulation MMP7 ELN 24946848 1087500 Positive_regulation MMP7 EPHB2 18629305 793177 Positive_regulation MMP7 EPHB2 21738525 922811 Positive_regulation MMP7 EPHB2 21814482 1057425 Positive_regulation MMP7 EPHB2 22310287 2146215 Positive_regulation MMP7 EPHB2 23663277 1678790 Positive_regulation MMP7 EPHB2 23671446 95689 Positive_regulation MMP7 EPHB2 24084727 1113159 Positive_regulation MMP7 ETS1 15165288 1694969 Positive_regulation MMP7 ETS1 22971289 472184 Positive_regulation MMP7 ETS1 22971289 472273 Positive_regulation MMP7 ETS1 24281073 501558 Positive_regulation MMP7 ETS2 15165288 1694970 Positive_regulation MMP7 ETS2 24281073 501559 Positive_regulation MMP7 ETV1 23076342 2171026 Positive_regulation MMP7 ETV1 23076342 2171027 Positive_regulation MMP7 ETV1 23076342 2171028 Positive_regulation MMP7 ETV1 23076342 2171029 Positive_regulation MMP7 ETV1 23076342 2171030 Positive_regulation MMP7 ETV1 23076342 2171031 Positive_regulation MMP7 ETV1 23076342 2171032 Positive_regulation MMP7 ETV1 23076342 2171041 Positive_regulation MMP7 ETV1 23076342 2171046 Positive_regulation MMP7 ETV1 23076342 2171053 Positive_regulation MMP7 ETV1 23076342 2171054 Positive_regulation MMP7 ETV1 24978435 504731 Positive_regulation MMP7 ETV4 24978435 504732 Positive_regulation MMP7 ETV4 25506469 3209626 Positive_regulation MMP7 EXOC7 23557484 166604 Positive_regulation MMP7 F2RL1 24278684 3150057 Positive_regulation MMP7 FASLG 23698793 3136020 Positive_regulation MMP7 FASLG 23698793 3136021 Positive_regulation MMP7 FASLG 23698793 3136064 Positive_regulation MMP7 FASLG 23698793 3136071 Positive_regulation MMP7 FASLG 23698793 3136073 Positive_regulation MMP7 FGF1 22292085 2593635 Positive_regulation MMP7 FGF10 22292085 2593636 Positive_regulation MMP7 FGF11 22292085 2593637 Positive_regulation MMP7 FGF12 22292085 2593638 Positive_regulation MMP7 FGF13 22292085 2593639 Positive_regulation MMP7 FGF14 22292085 2593640 Positive_regulation MMP7 FGF16 22292085 2593641 Positive_regulation MMP7 FGF17 22292085 2593642 Positive_regulation MMP7 FGF18 22292085 2593643 Positive_regulation MMP7 FGF19 22292085 2593644 Positive_regulation MMP7 FGF2 10684258 1255998 Positive_regulation MMP7 FGF2 16286510 1325403 Positive_regulation MMP7 FGF2 16286510 1325404 Positive_regulation MMP7 FGF2 16286510 1325405 Positive_regulation MMP7 FGF2 16286510 1325431 Positive_regulation MMP7 FGF2 22292085 2593645 Positive_regulation MMP7 FGF2 8554978 445216 Positive_regulation MMP7 FGF2 PMC2258055 1477107 Positive_regulation MMP7 FGF20 22292085 2593646 Positive_regulation MMP7 FGF21 22292085 2593647 Positive_regulation MMP7 FGF22 22292085 2593648 Positive_regulation MMP7 FGF23 22292085 2593649 Positive_regulation MMP7 FGF3 22292085 2593650 Positive_regulation MMP7 FGF4 22292085 2593651 Positive_regulation MMP7 FGF5 22292085 2593652 Positive_regulation MMP7 FGF6 22292085 2593653 Positive_regulation MMP7 FGF7 22292085 2593654 Positive_regulation MMP7 FGF8 22292085 2593655 Positive_regulation MMP7 FGF9 22292085 2593656 Positive_regulation MMP7 FGFR3 23617763 268276 Positive_regulation MMP7 FN1 18001488 109417 Positive_regulation MMP7 FN1 23259712 856331 Positive_regulation MMP7 FOS 21814482 1057426 Positive_regulation MMP7 FOS 25205949 90138 Positive_regulation MMP7 FURIN 11044366 418068 Positive_regulation MMP7 FURIN 23936445 2830488 Positive_regulation MMP7 GAST 20584780 1023269 Positive_regulation MMP7 GAST 20584780 1023270 Positive_regulation MMP7 GAST 20584780 1023282 Positive_regulation MMP7 GAST 20584780 1023283 Positive_regulation MMP7 GAST PMC2750788 450252 Positive_regulation MMP7 GLRX 18560520 2390934 Positive_regulation MMP7 GLRX 18560520 2390935 Positive_regulation MMP7 GLRX 18560520 2391049 Positive_regulation MMP7 GPI 24736611 2953213 Positive_regulation MMP7 GPR1 24066041 2850515 Positive_regulation MMP7 GPR101 24066041 2850471 Positive_regulation MMP7 GPR107 24066041 2850476 Positive_regulation MMP7 GPR108 24066041 2850475 Positive_regulation MMP7 GPR110 24066041 2850481 Positive_regulation MMP7 GPR111 24066041 2850482 Positive_regulation MMP7 GPR112 24066041 2850483 Positive_regulation MMP7 GPR113 24066041 2850480 Positive_regulation MMP7 GPR114 24066041 2850484 Positive_regulation MMP7 GPR115 24066041 2850485 Positive_regulation MMP7 GPR116 24066041 2850486 Positive_regulation MMP7 GPR119 24066041 2850487 Positive_regulation MMP7 GPR12 24066041 2850516 Positive_regulation MMP7 GPR123 24066041 2850468 Positive_regulation MMP7 GPR124 24066041 2850477 Positive_regulation MMP7 GPR125 24066041 2850469 Positive_regulation MMP7 GPR126 24066041 2850470 Positive_regulation MMP7 GPR128 24066041 2850488 Positive_regulation MMP7 GPR132 24066041 2850474 Positive_regulation MMP7 GPR133 24066041 2850489 Positive_regulation MMP7 GPR135 24066041 2850490 Positive_regulation MMP7 GPR137 24066041 2850508 Positive_regulation MMP7 GPR139 24066041 2850491 Positive_regulation MMP7 GPR141 24066041 2850492 Positive_regulation MMP7 GPR142 24066041 2850493 Positive_regulation MMP7 GPR143 24066041 2850494 Positive_regulation MMP7 GPR144 24066041 2850479 Positive_regulation MMP7 GPR146 24066041 2850496 Positive_regulation MMP7 GPR148 24066041 2850500 Positive_regulation MMP7 GPR149 24066041 2850502 Positive_regulation MMP7 GPR15 24066041 2850517 Positive_regulation MMP7 GPR150 24066041 2850503 Positive_regulation MMP7 GPR151 24066041 2850501 Positive_regulation MMP7 GPR152 24066041 2850499 Positive_regulation MMP7 GPR153 24066041 2850498 Positive_regulation MMP7 GPR155 24066041 2850497 Positive_regulation MMP7 GPR156 24066041 2850495 Positive_regulation MMP7 GPR157 24066041 2850504 Positive_regulation MMP7 GPR158 24066041 2850505 Positive_regulation MMP7 GPR160 24066041 2850506 Positive_regulation MMP7 GPR161 24066041 2850507 Positive_regulation MMP7 GPR162 24066041 2850472 Positive_regulation MMP7 GPR17 24066041 2850518 Positive_regulation MMP7 GPR171 24066041 2850510 Positive_regulation MMP7 GPR173 24066041 2850478 Positive_regulation MMP7 GPR174 24066041 2850511 Positive_regulation MMP7 GPR176 24066041 2850514 Positive_regulation MMP7 GPR179 24066041 2850513 Positive_regulation MMP7 GPR18 24066041 2850519 Positive_regulation MMP7 GPR180 24066041 2850509 Positive_regulation MMP7 GPR182 24066041 2850466 Positive_regulation MMP7 GPR183 24066041 2850512 Positive_regulation MMP7 GPR19 24066041 2850520 Positive_regulation MMP7 GPR20 24066041 2850521 Positive_regulation MMP7 GPR21 24066041 2850522 Positive_regulation MMP7 GPR22 24066041 2850523 Positive_regulation MMP7 GPR25 24066041 2850524 Positive_regulation MMP7 GPR26 24066041 2850525 Positive_regulation MMP7 GPR27 24066041 2850526 Positive_regulation MMP7 GPR3 24066041 2850527 Positive_regulation MMP7 GPR31 24066041 2850528 Positive_regulation MMP7 GPR32 24066041 2850529 Positive_regulation MMP7 GPR33 24066041 2850530 Positive_regulation MMP7 GPR34 24066041 2850531 Positive_regulation MMP7 GPR35 24066041 2850532 Positive_regulation MMP7 GPR36 24066041 2850533 Positive_regulation MMP7 GPR37 24066041 2850534 Positive_regulation MMP7 GPR39 24066041 2850535 Positive_regulation MMP7 GPR4 24066041 2850536 Positive_regulation MMP7 GPR42 24066041 2850537 Positive_regulation MMP7 GPR45 24066041 2850538 Positive_regulation MMP7 GPR50 24066041 2850539 Positive_regulation MMP7 GPR52 24066041 2850540 Positive_regulation MMP7 GPR55 24066041 2850541 Positive_regulation MMP7 GPR56 24066041 2850542 Positive_regulation MMP7 GPR6 24066041 2850543 Positive_regulation MMP7 GPR61 24066041 2850463 Positive_regulation MMP7 GPR62 24066041 2850464 Positive_regulation MMP7 GPR63 24066041 2850465 Positive_regulation MMP7 GPR64 24066041 2850544 Positive_regulation MMP7 GPR65 24066041 2850545 Positive_regulation MMP7 GPR68 24066041 2850546 Positive_regulation MMP7 GPR75 24066041 2850548 Positive_regulation MMP7 GPR78 24066041 2850549 Positive_regulation MMP7 GPR79 24066041 2850550 Positive_regulation MMP7 GPR82 24066041 2850551 Positive_regulation MMP7 GPR83 24066041 2850547 Positive_regulation MMP7 GPR84 24066041 2850552 Positive_regulation MMP7 GPR85 24066041 2850553 Positive_regulation MMP7 GPR87 24066041 2850554 Positive_regulation MMP7 GPR88 24066041 2850555 Positive_regulation MMP7 GPR97 24066041 2850467 Positive_regulation MMP7 GPR98 24066041 2850473 Positive_regulation MMP7 GRAP2 24084727 1113160 Positive_regulation MMP7 HBEGF 20584780 1023268 Positive_regulation MMP7 HBEGF 21179550 2489221 Positive_regulation MMP7 HBEGF 23119029 2712571 Positive_regulation MMP7 HDAC1 15899037 103226 Positive_regulation MMP7 HDAC1 15899037 103227 Positive_regulation MMP7 HDAC1 21143861 379684 Positive_regulation MMP7 HDAC1 24062615 1628705 Positive_regulation MMP7 HDAC10 15899037 103222 Positive_regulation MMP7 HDAC10 15899037 103223 Positive_regulation MMP7 HDAC11 15899037 103224 Positive_regulation MMP7 HDAC11 15899037 103225 Positive_regulation MMP7 HDAC2 15899037 103228 Positive_regulation MMP7 HDAC2 15899037 103229 Positive_regulation MMP7 HDAC2 21143861 379685 Positive_regulation MMP7 HDAC2 24062615 1628706 Positive_regulation MMP7 HDAC3 15899037 103230 Positive_regulation MMP7 HDAC3 15899037 103231 Positive_regulation MMP7 HDAC4 15899037 103212 Positive_regulation MMP7 HDAC4 15899037 103213 Positive_regulation MMP7 HDAC5 15899037 103220 Positive_regulation MMP7 HDAC5 15899037 103221 Positive_regulation MMP7 HDAC6 15899037 103214 Positive_regulation MMP7 HDAC6 15899037 103215 Positive_regulation MMP7 HDAC7 15899037 103218 Positive_regulation MMP7 HDAC7 15899037 103219 Positive_regulation MMP7 HDAC8 15899037 103210 Positive_regulation MMP7 HDAC8 15899037 103211 Positive_regulation MMP7 HDAC9 15899037 103216 Positive_regulation MMP7 HDAC9 15899037 103217 Positive_regulation MMP7 HGF 20551596 3078748 Positive_regulation MMP7 HRAS 23365639 2745285 Positive_regulation MMP7 HSPD1 23956742 1146962 Positive_regulation MMP7 IFI44 20109185 284151 Positive_regulation MMP7 IGF1 22860018 2670907 Positive_regulation MMP7 IGF1 24717414 1703649 Positive_regulation MMP7 IGF1 24717414 1703695 Positive_regulation MMP7 IL11 25352758 1716805 Positive_regulation MMP7 IL13 24279676 856808 Positive_regulation MMP7 IL13 24904424 954590 Positive_regulation MMP7 IL17A 15987479 103878 Positive_regulation MMP7 IL17A 15987479 103922 Positive_regulation MMP7 IL17A 19627579 116126 Positive_regulation MMP7 IL17A 19627579 116178 Positive_regulation MMP7 IL17A 19627579 116265 Positive_regulation MMP7 IL17A 23372655 2745650 Positive_regulation MMP7 IL17A 24022789 1919986 Positive_regulation MMP7 IL18 11805151 1522704 Positive_regulation MMP7 IL1A 15380034 101711 Positive_regulation MMP7 IL1A 15566575 3104167 Positive_regulation MMP7 IL1A 15743487 102607 Positive_regulation MMP7 IL1A 16207333 104441 Positive_regulation MMP7 IL1A 16262900 3105770 Positive_regulation MMP7 IL1A 16792821 106166 Positive_regulation MMP7 IL1A 17096856 1695595 Positive_regulation MMP7 IL1A 17925024 109242 Positive_regulation MMP7 IL1A 18604259 810806 Positive_regulation MMP7 IL1A 19226472 112881 Positive_regulation MMP7 IL1A 19296842 113028 Positive_regulation MMP7 IL1A 19309495 3226060 Positive_regulation MMP7 IL1A 19567787 2251197 Positive_regulation MMP7 IL1A 19765281 116790 Positive_regulation MMP7 IL1A 19765281 116791 Positive_regulation MMP7 IL1A 19765281 117222 Positive_regulation MMP7 IL1A 19919704 117828 Positive_regulation MMP7 IL1A 19919704 117852 Positive_regulation MMP7 IL1A 20307272 118466 Positive_regulation MMP7 IL1A 20307272 118467 Positive_regulation MMP7 IL1A 20307272 118491 Positive_regulation MMP7 IL1A 20307272 118515 Positive_regulation MMP7 IL1A 20307272 118538 Positive_regulation MMP7 IL1A 20307272 118561 Positive_regulation MMP7 IL1A 20360891 1078118 Positive_regulation MMP7 IL1A 20799933 119809 Positive_regulation MMP7 IL1A 22046527 97450 Positive_regulation MMP7 IL1A 22359588 2597974 Positive_regulation MMP7 IL1A 22359588 2598182 Positive_regulation MMP7 IL1A 22987043 694290 Positive_regulation MMP7 IL1A 23342250 491623 Positive_regulation MMP7 IL1A 23342250 491624 Positive_regulation MMP7 IL1A 23342250 491625 Positive_regulation MMP7 IL1A 23342250 491626 Positive_regulation MMP7 IL1A 23342250 491627 Positive_regulation MMP7 IL1A 23342250 491628 Positive_regulation MMP7 IL1A 23342250 491660 Positive_regulation MMP7 IL1A 23342250 491697 Positive_regulation MMP7 IL1A 23342250 491730 Positive_regulation MMP7 IL1A 23342250 491755 Positive_regulation MMP7 IL1A 23658758 2790176 Positive_regulation MMP7 IL1A 23874391 2821247 Positive_regulation MMP7 IL1A 23889808 1627233 Positive_regulation MMP7 IL1A 23965253 129257 Positive_regulation MMP7 IL1A 24236107 2878559 Positive_regulation MMP7 IL1A 24238405 129979 Positive_regulation MMP7 IL1A 24349175 2896961 Positive_regulation MMP7 IL1A 24349175 2897018 Positive_regulation MMP7 IL1A 24556326 3209491 Positive_regulation MMP7 IL1A 24817792 1758532 Positive_regulation MMP7 IL1A 24977073 1154334 Positive_regulation MMP7 IL1A 24984954 132785 Positive_regulation MMP7 IL1A 24984954 132840 Positive_regulation MMP7 IL1A 25143751 645574 Positive_regulation MMP7 IL1A 25312962 1485601 Positive_regulation MMP7 IL1A 9792142 447949 Positive_regulation MMP7 IL1A 9792142 447951 Positive_regulation MMP7 IL1B 15203568 1739676 Positive_regulation MMP7 IL24 24270662 1632368 Positive_regulation MMP7 IL24 24270662 1632375 Positive_regulation MMP7 IL6 19883500 117600 Positive_regulation MMP7 IL6 20543948 2452508 Positive_regulation MMP7 IL6 21484455 1718762 Positive_regulation MMP7 IL6 24977073 1154335 Positive_regulation MMP7 IL8 19883500 117601 Positive_regulation MMP7 IL8 21278918 1057007 Positive_regulation MMP7 IL8 22891766 245291 Positive_regulation MMP7 IL8 23365550 3154076 Positive_regulation MMP7 IL8 23941552 1507118 Positive_regulation MMP7 IL8 24912917 1043565 Positive_regulation MMP7 INHBA 25075578 454148 Positive_regulation MMP7 ITGA2 21288331 855261 Positive_regulation MMP7 ITIH4 22132194 2574492 Positive_regulation MMP7 ITIH4 22132194 2574493 Positive_regulation MMP7 ITIH4 22132194 2574519 Positive_regulation MMP7 JUN 14979937 100204 Positive_regulation MMP7 JUN 15770046 1739875 Positive_regulation MMP7 JUN 16552434 427279 Positive_regulation MMP7 JUN 17559674 108350 Positive_regulation MMP7 JUN 20939893 1859811 Positive_regulation MMP7 JUN 21814482 1057427 Positive_regulation MMP7 JUN 23226337 2724189 Positive_regulation MMP7 JUN 23467702 696416 Positive_regulation MMP7 JUN 23551430 1480235 Positive_regulation MMP7 JUN 24212934 499175 Positive_regulation MMP7 JUN 24281073 501560 Positive_regulation MMP7 JUN 24349175 2896962 Positive_regulation MMP7 JUN 24976858 1650893 Positive_regulation MMP7 JUN 25205949 90139 Positive_regulation MMP7 KLF8 21151179 2137005 Positive_regulation MMP7 KRAS 23365639 2745286 Positive_regulation MMP7 KRT13 23552603 2156201 Positive_regulation MMP7 L1CAM 21541352 2517075 Positive_regulation MMP7 LAMA3 23110919 1639904 Positive_regulation MMP7 LAMB1 23110919 1639905 Positive_regulation MMP7 LAMC1 23110919 1639906 Positive_regulation MMP7 LEP 21826146 1144727 Positive_regulation MMP7 LGALS3BP 23251263 842902 Positive_regulation MMP7 LPA 21151531 1081418 Positive_regulation MMP7 LPA 22627809 834831 Positive_regulation MMP7 LPA 25356505 1133381 Positive_regulation MMP7 LPAR1 25356505 1133375 Positive_regulation MMP7 LPAR1 25356505 1133376 Positive_regulation MMP7 LTB 12516548 2001381 Positive_regulation MMP7 MAP2K1 20667128 1857635 Positive_regulation MMP7 MAP2K2 20667128 1857636 Positive_regulation MMP7 MAP2K3 20667128 1857637 Positive_regulation MMP7 MAP2K4 20667128 1857638 Positive_regulation MMP7 MAP2K4 22353730 124810 Positive_regulation MMP7 MAP2K5 20667128 1857639 Positive_regulation MMP7 MAP2K6 20667128 1857640 Positive_regulation MMP7 MAP2K7 20667128 1857641 Positive_regulation MMP7 MAP2K7 22353730 124811 Positive_regulation MMP7 MAP4K4 24244164 3064981 Positive_regulation MMP7 MAP4K4 24244164 3064988 Positive_regulation MMP7 MAPK1 20667128 1857444 Positive_regulation MMP7 MAPK1 20667128 1857740 Positive_regulation MMP7 MAPK1 21814482 1057462 Positive_regulation MMP7 MAPK1 21814482 1057488 Positive_regulation MMP7 MAPK1 22570668 634701 Positive_regulation MMP7 MAPK1 23671446 95690 Positive_regulation MMP7 MAPK1 23760725 2165163 Positive_regulation MMP7 MAPK1 24204703 2873762 Positive_regulation MMP7 MAPK1 25520932 203431 Positive_regulation MMP7 MAPK10 20667128 1857445 Positive_regulation MMP7 MAPK10 21814482 1057463 Positive_regulation MMP7 MAPK10 21814482 1057489 Positive_regulation MMP7 MAPK10 22570668 634702 Positive_regulation MMP7 MAPK10 23671446 95691 Positive_regulation MMP7 MAPK10 23760725 2165164 Positive_regulation MMP7 MAPK10 24204703 2873763 Positive_regulation MMP7 MAPK10 25520932 203432 Positive_regulation MMP7 MAPK11 20667128 1857446 Positive_regulation MMP7 MAPK11 21814482 1057464 Positive_regulation MMP7 MAPK11 21814482 1057490 Positive_regulation MMP7 MAPK11 22570668 634703 Positive_regulation MMP7 MAPK11 23671446 95692 Positive_regulation MMP7 MAPK11 23760725 2165165 Positive_regulation MMP7 MAPK11 24204703 2873764 Positive_regulation MMP7 MAPK11 25520932 203433 Positive_regulation MMP7 MAPK12 20667128 1857447 Positive_regulation MMP7 MAPK12 21814482 1057465 Positive_regulation MMP7 MAPK12 21814482 1057491 Positive_regulation MMP7 MAPK12 22570668 634704 Positive_regulation MMP7 MAPK12 23671446 95693 Positive_regulation MMP7 MAPK12 23760725 2165166 Positive_regulation MMP7 MAPK12 24204703 2873765 Positive_regulation MMP7 MAPK12 25520932 203434 Positive_regulation MMP7 MAPK13 20667128 1857448 Positive_regulation MMP7 MAPK13 21814482 1057466 Positive_regulation MMP7 MAPK13 21814482 1057492 Positive_regulation MMP7 MAPK13 22570668 634705 Positive_regulation MMP7 MAPK13 23671446 95694 Positive_regulation MMP7 MAPK13 23760725 2165167 Positive_regulation MMP7 MAPK13 24204703 2873766 Positive_regulation MMP7 MAPK13 25520932 203435 Positive_regulation MMP7 MAPK14 20667128 1857449 Positive_regulation MMP7 MAPK14 21814482 1057467 Positive_regulation MMP7 MAPK14 21814482 1057493 Positive_regulation MMP7 MAPK14 22570668 634706 Positive_regulation MMP7 MAPK14 23671446 95695 Positive_regulation MMP7 MAPK14 23760725 2165168 Positive_regulation MMP7 MAPK14 24204703 2873767 Positive_regulation MMP7 MAPK14 25520932 203436 Positive_regulation MMP7 MAPK15 20667128 1857443 Positive_regulation MMP7 MAPK15 21814482 1057461 Positive_regulation MMP7 MAPK15 21814482 1057487 Positive_regulation MMP7 MAPK15 22570668 634700 Positive_regulation MMP7 MAPK15 23671446 95688 Positive_regulation MMP7 MAPK15 23760725 2165162 Positive_regulation MMP7 MAPK15 24204703 2873761 Positive_regulation MMP7 MAPK15 25520932 203430 Positive_regulation MMP7 MAPK3 20667128 1857450 Positive_regulation MMP7 MAPK3 20667128 1857741 Positive_regulation MMP7 MAPK3 21814482 1057468 Positive_regulation MMP7 MAPK3 21814482 1057494 Positive_regulation MMP7 MAPK3 22570668 634707 Positive_regulation MMP7 MAPK3 23671446 95696 Positive_regulation MMP7 MAPK3 23760725 2165169 Positive_regulation MMP7 MAPK3 24135872 1113529 Positive_regulation MMP7 MAPK3 24204703 2873768 Positive_regulation MMP7 MAPK3 25520932 203437 Positive_regulation MMP7 MAPK4 20667128 1857451 Positive_regulation MMP7 MAPK4 21814482 1057469 Positive_regulation MMP7 MAPK4 21814482 1057495 Positive_regulation MMP7 MAPK4 22570668 634708 Positive_regulation MMP7 MAPK4 23671446 95697 Positive_regulation MMP7 MAPK4 23760725 2165170 Positive_regulation MMP7 MAPK4 24204703 2873769 Positive_regulation MMP7 MAPK4 25520932 203438 Positive_regulation MMP7 MAPK6 20667128 1857452 Positive_regulation MMP7 MAPK6 21814482 1057470 Positive_regulation MMP7 MAPK6 21814482 1057496 Positive_regulation MMP7 MAPK6 22570668 634709 Positive_regulation MMP7 MAPK6 23671446 95698 Positive_regulation MMP7 MAPK6 23760725 2165171 Positive_regulation MMP7 MAPK6 24204703 2873770 Positive_regulation MMP7 MAPK6 25520932 203439 Positive_regulation MMP7 MAPK7 20667128 1857453 Positive_regulation MMP7 MAPK7 21814482 1057471 Positive_regulation MMP7 MAPK7 21814482 1057497 Positive_regulation MMP7 MAPK7 22570668 634710 Positive_regulation MMP7 MAPK7 23671446 95699 Positive_regulation MMP7 MAPK7 23760725 2165172 Positive_regulation MMP7 MAPK7 24204703 2873771 Positive_regulation MMP7 MAPK7 25520932 203440 Positive_regulation MMP7 MAPK8 20667128 1857454 Positive_regulation MMP7 MAPK8 21814482 1057472 Positive_regulation MMP7 MAPK8 21814482 1057498 Positive_regulation MMP7 MAPK8 22570668 634711 Positive_regulation MMP7 MAPK8 23028407 2219706 Positive_regulation MMP7 MAPK8 23671446 95700 Positive_regulation MMP7 MAPK8 23760725 2165173 Positive_regulation MMP7 MAPK8 24204703 2873772 Positive_regulation MMP7 MAPK8 25520932 203441 Positive_regulation MMP7 MAPK9 20667128 1857455 Positive_regulation MMP7 MAPK9 21814482 1057473 Positive_regulation MMP7 MAPK9 21814482 1057499 Positive_regulation MMP7 MAPK9 22570668 634712 Positive_regulation MMP7 MAPK9 23671446 95701 Positive_regulation MMP7 MAPK9 23760725 2165174 Positive_regulation MMP7 MAPK9 24204703 2873773 Positive_regulation MMP7 MAPK9 25520932 203442 Positive_regulation MMP7 MATR3 21771347 3119761 Positive_regulation MMP7 MCAT 25133539 2998698 Positive_regulation MMP7 MCL1 21304825 2500011 Positive_regulation MMP7 MCS 23342045 2741835 Positive_regulation MMP7 MDM2 24236052 2878305 Positive_regulation MMP7 MFN2 22438978 2612513 Positive_regulation MMP7 MIF 19435478 113217 Positive_regulation MMP7 MIF 23050964 89492 Positive_regulation MMP7 MIF 24069610 184261 Positive_regulation MMP7 MIF 24586879 2927843 Positive_regulation MMP7 MIP 21347304 2503611 Positive_regulation MMP7 MIR21 23788041 563275 Positive_regulation MMP7 MIR9-2 23820254 441132 Positive_regulation MMP7 MIR9-2 23820254 441133 Positive_regulation MMP7 MME 22642296 1230736 Positive_regulation MMP7 MMP1 19226472 112882 Positive_regulation MMP7 MMP1 8554978 445217 Positive_regulation MMP7 MMP10 20204159 1671997 Positive_regulation MMP7 MMP13 21787393 229544 Positive_regulation MMP7 MMP13 23028407 2219845 Positive_regulation MMP7 MMP2 11401321 419058 Positive_regulation MMP7 MMP2 20587068 256547 Positive_regulation MMP7 MMP2 21729302 3101296 Positive_regulation MMP7 MMP2 23388158 521810 Positive_regulation MMP7 MMP2 24441189 806927 Positive_regulation MMP7 MMP2 24806521 2962462 Positive_regulation MMP7 MMP3 19226472 112883 Positive_regulation MMP7 MMP3 21455784 2012505 Positive_regulation MMP7 MMP3 24273653 2251305 Positive_regulation MMP7 MMP3 24519465 2243675 Positive_regulation MMP7 MMP3 25352733 1917305 Positive_regulation MMP7 MMP8 20442866 3046747 Positive_regulation MMP7 MMP9 21729302 3101297 Positive_regulation MMP7 MMP9 21787393 229545 Positive_regulation MMP7 MMP9 24465581 2910814 Positive_regulation MMP7 MOCOS 24517261 131743 Positive_regulation MMP7 MRC1 23937653 380375 Positive_regulation MMP7 MRC2 23937653 380374 Positive_regulation MMP7 MSC 23236386 2726064 Positive_regulation MMP7 MSC 24775918 3114586 Positive_regulation MMP7 MSLN 23694968 3135768 Positive_regulation MMP7 MSLN 23694968 3135769 Positive_regulation MMP7 MSLN 23694968 3135770 Positive_regulation MMP7 MSLN 23694968 3135771 Positive_regulation MMP7 MSLN 23694968 3135813 Positive_regulation MMP7 MSLN 23694968 3135954 Positive_regulation MMP7 MSLN 23694968 3135998 Positive_regulation MMP7 MSLN 23694968 3136006 Positive_regulation MMP7 MSLN 23694968 3136007 Positive_regulation MMP7 MSLN 23694968 3136008 Positive_regulation MMP7 MSLN 23694968 3136017 Positive_regulation MMP7 MTOR 18516228 3041420 Positive_regulation MMP7 MUC16 23694968 3135765 Positive_regulation MMP7 MUC16 23694968 3135766 Positive_regulation MMP7 MUC16 23694968 3135767 Positive_regulation MMP7 MUC16 23694968 3135802 Positive_regulation MMP7 MUC16 23694968 3135812 Positive_regulation MMP7 MUC16 23694968 3136004 Positive_regulation MMP7 MUC16 23694968 3136005 Positive_regulation MMP7 MUC16 23694968 3136016 Positive_regulation MMP7 MYC 23365639 2745287 Positive_regulation MMP7 MYLIP 23437250 2756306 Positive_regulation MMP7 MYLIP 23437250 2756310 Positive_regulation MMP7 MYLIP 23820254 441192 Positive_regulation MMP7 MYLIP 23857777 781443 Positive_regulation MMP7 NA 21192843 623513 Positive_regulation MMP7 NA 21569548 259742 Positive_regulation MMP7 NA 21991373 2561613 Positive_regulation MMP7 NA 23760725 2165175 Positive_regulation MMP7 NA 24260080 2167093 Positive_regulation MMP7 NA 25019272 2988647 Positive_regulation MMP7 NAMPT 23797661 1107936 Positive_regulation MMP7 NCOA3 21577200 2139499 Positive_regulation MMP7 NFATC2 23762456 2803608 Positive_regulation MMP7 NFATC2 23762456 2803612 Positive_regulation MMP7 NFKB1 15770046 1739876 Positive_regulation MMP7 NFKB1 22570691 2631240 Positive_regulation MMP7 NFKB1 23226337 2724190 Positive_regulation MMP7 NFKB1 23482348 2182570 Positive_regulation MMP7 NOS2 22936987 2682638 Positive_regulation MMP7 NOS2 23894457 2824768 Positive_regulation MMP7 NOTCH1 24749110 1022501 Positive_regulation MMP7 NOTCH2 24749110 1022502 Positive_regulation MMP7 NOTCH3 24749110 1022503 Positive_regulation MMP7 NOTCH4 24749110 1022504 Positive_regulation MMP7 NOV 22353423 1661137 Positive_regulation MMP7 NOX1 23840100 1753689 Positive_regulation MMP7 NOX3 23840100 1753690 Positive_regulation MMP7 NOX4 23840100 1753691 Positive_regulation MMP7 NOX5 23840100 1753688 Positive_regulation MMP7 NPR1 24885858 3226748 Positive_regulation MMP7 NR4A1 24851101 1039890 Positive_regulation MMP7 NR4A1 24851101 1039912 Positive_regulation MMP7 NRAS 23028410 2220001 Positive_regulation MMP7 NRAS 23365639 2745288 Positive_regulation MMP7 NUP43 20109185 284152 Positive_regulation MMP7 OPN1SW 16207333 104403 Positive_regulation MMP7 OSM 25057495 195475 Positive_regulation MMP7 P2RY2 25238333 2201318 Positive_regulation MMP7 P2RY2 25238333 2201348 Positive_regulation MMP7 PAK2 20111678 1089108 Positive_regulation MMP7 PAK2 20111678 1089196 Positive_regulation MMP7 PARK7 20186336 2441695 Positive_regulation MMP7 PARP1 22906755 154148 Positive_regulation MMP7 PBRM1 18516228 3041508 Positive_regulation MMP7 PBX2 20637111 1647209 Positive_regulation MMP7 PBX2 20637111 1647210 Positive_regulation MMP7 PBX2 20637111 1647211 Positive_regulation MMP7 PBX2 20637111 1647215 Positive_regulation MMP7 PBX2 20637111 1647216 Positive_regulation MMP7 PBX2 20637111 1647217 Positive_regulation MMP7 PBX2 20637111 1647218 Positive_regulation MMP7 PDLIM7 24885469 273313 Positive_regulation MMP7 PECAM1 12591918 1291199 Positive_regulation MMP7 PGF 23805043 1915992 Positive_regulation MMP7 PHB 20856874 2474892 Positive_regulation MMP7 PIK3CA 16551362 249302 Positive_regulation MMP7 PIK3CA 19775453 254292 Positive_regulation MMP7 PIK3CA 23061721 533417 Positive_regulation MMP7 PIK3CA 23383143 2748236 Positive_regulation MMP7 PIK3CA 23797661 1107940 Positive_regulation MMP7 PIK3CA 25147440 1761507 Positive_regulation MMP7 PIK3R1 16551362 249303 Positive_regulation MMP7 PIK3R1 19775453 254293 Positive_regulation MMP7 PIK3R1 23061721 533418 Positive_regulation MMP7 PIK3R1 23383143 2748237 Positive_regulation MMP7 PIK3R1 23797661 1107941 Positive_regulation MMP7 PIK3R1 25147440 1761508 Positive_regulation MMP7 PLAT 23977299 2839957 Positive_regulation MMP7 PLAT 24303218 2003302 Positive_regulation MMP7 PLAU 24189182 787877 Positive_regulation MMP7 PLAU 9083329 446130 Positive_regulation MMP7 PLD1 23752189 2152561 Positive_regulation MMP7 PLD2 23752189 2152562 Positive_regulation MMP7 PLD3 23752189 2152557 Positive_regulation MMP7 PLD4 23752189 2152558 Positive_regulation MMP7 PLD5 23752189 2152559 Positive_regulation MMP7 PLD6 23752189 2152560 Positive_regulation MMP7 PLG 18700005 396162 Positive_regulation MMP7 PLG 20204159 1671998 Positive_regulation MMP7 PLG 22384127 2606298 Positive_regulation MMP7 PLG 22563394 2626205 Positive_regulation MMP7 PLG 23008698 833300 Positive_regulation MMP7 PLG 23724005 2798901 Positive_regulation MMP7 PLG 24273653 2251306 Positive_regulation MMP7 PLG 9083329 446131 Positive_regulation MMP7 PLG 9635853 447180 Positive_regulation MMP7 POLDIP2 12010565 98885 Positive_regulation MMP7 POLDIP2 23663277 1678789 Positive_regulation MMP7 PRDX2 24062615 1628881 Positive_regulation MMP7 PRKAA1 23561047 509609 Positive_regulation MMP7 PRKAA2 23561047 509610 Positive_regulation MMP7 PRKAB1 23561047 509611 Positive_regulation MMP7 PRKAB2 23561047 509612 Positive_regulation MMP7 PRKAG1 23561047 509613 Positive_regulation MMP7 PRKAG2 23561047 509614 Positive_regulation MMP7 PRKD1 23562655 829767 Positive_regulation MMP7 PROL1 25220640 19767 Positive_regulation MMP7 PTGER4 22570740 2631806 Positive_regulation MMP7 PTGS2 15482602 668294 Positive_regulation MMP7 PTGS2 20169190 3046298 Positive_regulation MMP7 PTGS2 21457581 3178059 Positive_regulation MMP7 PTGS2 23270317 412354 Positive_regulation MMP7 PTGS2 24817792 1758533 Positive_regulation MMP7 PTP4A3 25220640 19768 Positive_regulation MMP7 PTP4A3 25220640 19778 Positive_regulation MMP7 PTPRC 18779349 1551965 Positive_regulation MMP7 RALA 21179550 2489047 Positive_regulation MMP7 RANBP9 23348590 559335 Positive_regulation MMP7 RASGRF1 19678938 116443 Positive_regulation MMP7 RASGRF1 19678938 116444 Positive_regulation MMP7 RBBP4 21143861 379686 Positive_regulation MMP7 RBBP4 24062615 1628707 Positive_regulation MMP7 RBBP7 21143861 379687 Positive_regulation MMP7 RBBP7 24062615 1628708 Positive_regulation MMP7 RBPJ 24971735 612524 Positive_regulation MMP7 REG4 21494603 2513263 Positive_regulation MMP7 RELA 15770046 1739877 Positive_regulation MMP7 RELA 22570691 2631241 Positive_regulation MMP7 RELA 23226337 2724191 Positive_regulation MMP7 RELA 23482348 2182571 Positive_regulation MMP7 RHOA 16552434 427280 Positive_regulation MMP7 RLN1 15642129 101994 Positive_regulation MMP7 RLN1 22936987 2682292 Positive_regulation MMP7 RLN1 22936987 2682293 Positive_regulation MMP7 RLN1 22936987 2682588 Positive_regulation MMP7 RLN2 15642129 101995 Positive_regulation MMP7 RLN2 22936987 2682294 Positive_regulation MMP7 RLN2 22936987 2682295 Positive_regulation MMP7 RLN2 22936987 2682589 Positive_regulation MMP7 RLN3 15642129 101996 Positive_regulation MMP7 RLN3 22936987 2682296 Positive_regulation MMP7 RLN3 22936987 2682297 Positive_regulation MMP7 RLN3 22936987 2682590 Positive_regulation MMP7 RNF146 24454854 2910162 Positive_regulation MMP7 RNF146 24454854 2910181 Positive_regulation MMP7 RNF146 24454854 2910182 Positive_regulation MMP7 RNF146 24454854 2910190 Positive_regulation MMP7 RNF19A 22570668 634699 Positive_regulation MMP7 RPH3AL 11980922 1282577 Positive_regulation MMP7 RUNX2 19915614 2128197 Positive_regulation MMP7 S100A12 23638054 2787413 Positive_regulation MMP7 S100A4 20442771 2448903 Positive_regulation MMP7 S100A4 22782346 439005 Positive_regulation MMP7 S100A8 23637971 2786819 Positive_regulation MMP7 S100A9 23637971 2786820 Positive_regulation MMP7 SATB1 24176859 568885 Positive_regulation MMP7 SERPINF1 22690122 1224350 Positive_regulation MMP7 SETD2 21847402 1238197 Positive_regulation MMP7 SFN 23662110 818765 Positive_regulation MMP7 SIRT1 20920189 3110949 Positive_regulation MMP7 SLC17A5 25215580 1484950 Positive_regulation MMP7 SLC9A1 PMC2756345 496297 Positive_regulation MMP7 SNAP25 23028481 2691050 Positive_regulation MMP7 SOX18 22292085 2593632 Positive_regulation MMP7 SP1 24755270 272800 Positive_regulation MMP7 SPARC 21192846 623540 Positive_regulation MMP7 SPARC 25147739 413739 Positive_regulation MMP7 SPARC 25147739 413787 Positive_regulation MMP7 SPN 25414930 177664 Positive_regulation MMP7 SPP1 16128620 2368443 Positive_regulation MMP7 SPP1 16128620 2368475 Positive_regulation MMP7 SPP1 16128620 2368476 Positive_regulation MMP7 SPP1 20868520 1859519 Positive_regulation MMP7 SPP1 24944898 1887956 Positive_regulation MMP7 SRC 20167811 2007813 Positive_regulation MMP7 SRC 24319683 185599 Positive_regulation MMP7 SSFA2 7537277 1436596 Positive_regulation MMP7 SSFA2 7537277 1436641 Positive_regulation MMP7 STAT3 20939893 1859810 Positive_regulation MMP7 STAT3 21991388 2561751 Positive_regulation MMP7 STAT3 23170143 1024271 Positive_regulation MMP7 STAT3 23820254 441130 Positive_regulation MMP7 STAT3 23820254 441131 Positive_regulation MMP7 STAT3 23820254 441191 Positive_regulation MMP7 STAT3 24107265 1870078 Positive_regulation MMP7 STAT3 24199193 184802 Positive_regulation MMP7 STAT3 25143751 645572 Positive_regulation MMP7 STS 22937143 2683078 Positive_regulation MMP7 SYT1 24755270 272801 Positive_regulation MMP7 TAGLN 25050546 2990979 Positive_regulation MMP7 TAT 22419111 555186 Positive_regulation MMP7 TAT 22419111 555228 Positive_regulation MMP7 TAT 24359561 3216127 Positive_regulation MMP7 TBX22 12756268 1527086 Positive_regulation MMP7 TBX22 12756268 1527087 Positive_regulation MMP7 TBX22 12756268 1527113 Positive_regulation MMP7 TBX22 12756268 1527174 Positive_regulation MMP7 TBX22 12756268 1527175 Positive_regulation MMP7 TBX22 12756268 1527311 Positive_regulation MMP7 TBX22 12756268 1527312 Positive_regulation MMP7 TBX22 12756268 1527358 Positive_regulation MMP7 TBX22 12756268 1527402 Positive_regulation MMP7 TCEA1 12975354 1297352 Positive_regulation MMP7 TCF12 16622451 427475 Positive_regulation MMP7 TCF12 19924227 2431313 Positive_regulation MMP7 TCF12 24926361 844469 Positive_regulation MMP7 TCF12 24971028 1629170 Positive_regulation MMP7 TCF12 25029110 2989682 Positive_regulation MMP7 TCF15 16622451 427476 Positive_regulation MMP7 TCF15 19924227 2431314 Positive_regulation MMP7 TCF15 24926361 844470 Positive_regulation MMP7 TCF15 24971028 1629171 Positive_regulation MMP7 TCF15 25029110 2989683 Positive_regulation MMP7 TCF19 16622451 427477 Positive_regulation MMP7 TCF19 19924227 2431315 Positive_regulation MMP7 TCF19 24926361 844471 Positive_regulation MMP7 TCF19 24971028 1629172 Positive_regulation MMP7 TCF19 25029110 2989684 Positive_regulation MMP7 TCF20 16622451 427478 Positive_regulation MMP7 TCF20 19924227 2431316 Positive_regulation MMP7 TCF20 24926361 844472 Positive_regulation MMP7 TCF20 24971028 1629173 Positive_regulation MMP7 TCF20 25029110 2989685 Positive_regulation MMP7 TCF21 16622451 427479 Positive_regulation MMP7 TCF21 19924227 2431317 Positive_regulation MMP7 TCF21 24926361 844473 Positive_regulation MMP7 TCF21 24971028 1629174 Positive_regulation MMP7 TCF21 25029110 2989686 Positive_regulation MMP7 TCF23 16622451 427484 Positive_regulation MMP7 TCF23 19924227 2431321 Positive_regulation MMP7 TCF23 24926361 844478 Positive_regulation MMP7 TCF23 24971028 1629178 Positive_regulation MMP7 TCF23 25029110 2989690 Positive_regulation MMP7 TCF24 16622451 427486 Positive_regulation MMP7 TCF24 19924227 2431323 Positive_regulation MMP7 TCF24 24926361 844480 Positive_regulation MMP7 TCF24 24971028 1629180 Positive_regulation MMP7 TCF24 25029110 2989692 Positive_regulation MMP7 TCF25 16622451 427485 Positive_regulation MMP7 TCF25 19924227 2431322 Positive_regulation MMP7 TCF25 24926361 844479 Positive_regulation MMP7 TCF25 24971028 1629179 Positive_regulation MMP7 TCF25 25029110 2989691 Positive_regulation MMP7 TCF3 16622451 427480 Positive_regulation MMP7 TCF3 19924227 2431318 Positive_regulation MMP7 TCF3 24926361 844474 Positive_regulation MMP7 TCF3 24971028 1629175 Positive_regulation MMP7 TCF3 25029110 2989687 Positive_regulation MMP7 TCF4 16622451 427481 Positive_regulation MMP7 TCF4 19924227 2431319 Positive_regulation MMP7 TCF4 24926361 844475 Positive_regulation MMP7 TCF4 24971028 1629176 Positive_regulation MMP7 TCF4 25029110 2989688 Positive_regulation MMP7 TCF7 16622451 427482 Positive_regulation MMP7 TCF7 19924227 2431320 Positive_regulation MMP7 TCF7 24926361 844476 Positive_regulation MMP7 TCF7 24971028 1629177 Positive_regulation MMP7 TCF7 25029110 2989689 Positive_regulation MMP7 TCF7L2 16622451 427483 Positive_regulation MMP7 TERT 24388106 222495 Positive_regulation MMP7 TFPI2 23905012 853460 Positive_regulation MMP7 TFPI2 PMC2756345 496098 Positive_regulation MMP7 TGFA 9744504 447910 Positive_regulation MMP7 TGFB1I1 24811612 1159566 Positive_regulation MMP7 TGFB2 22815623 1914664 Positive_regulation MMP7 TGM2 24130925 204518 Positive_regulation MMP7 THBS1 11980922 1282529 Positive_regulation MMP7 THBS1 11980922 1282530 Positive_regulation MMP7 THBS1 11980922 1282578 Positive_regulation MMP7 THBS1 11980922 1282579 Positive_regulation MMP7 THBS1 21423603 2508110 Positive_regulation MMP7 THBS2 11980922 1282531 Positive_regulation MMP7 TIMP1 12975354 1297353 Positive_regulation MMP7 TIMP1 20012240 495700 Positive_regulation MMP7 TIMP1 22911824 2676984 Positive_regulation MMP7 TIMP1 23187000 219747 Positive_regulation MMP7 TIMP1 23304261 2225397 Positive_regulation MMP7 TIMP1 23715597 1886201 Positive_regulation MMP7 TIMP1 24766991 1675793 Positive_regulation MMP7 TIMP1 24860785 947897 Positive_regulation MMP7 TIMP2 21861887 3112530 Positive_regulation MMP7 TIMP2 22911824 2676985 Positive_regulation MMP7 TIMP2 24231999 1137934 Positive_regulation MMP7 TIMP2 24766991 1675823 Positive_regulation MMP7 TLR1 17129374 107355 Positive_regulation MMP7 TLR1 23940584 2831811 Positive_regulation MMP7 TLR10 17129374 107363 Positive_regulation MMP7 TLR10 23940584 2831819 Positive_regulation MMP7 TLR2 17129374 107356 Positive_regulation MMP7 TLR2 20652007 1747515 Positive_regulation MMP7 TLR2 23940584 2831812 Positive_regulation MMP7 TLR3 17129374 107357 Positive_regulation MMP7 TLR3 23940584 2831813 Positive_regulation MMP7 TLR4 17129374 107358 Positive_regulation MMP7 TLR4 23940584 2831814 Positive_regulation MMP7 TLR5 17129374 107359 Positive_regulation MMP7 TLR5 23940584 2831815 Positive_regulation MMP7 TLR6 17129374 107364 Positive_regulation MMP7 TLR6 23940584 2831820 Positive_regulation MMP7 TLR7 17129374 107360 Positive_regulation MMP7 TLR7 23940584 2831816 Positive_regulation MMP7 TLR8 17129374 107361 Positive_regulation MMP7 TLR8 23940584 2831817 Positive_regulation MMP7 TLR9 17129374 107362 Positive_regulation MMP7 TLR9 23940584 2831818 Positive_regulation MMP7 TLR9 24959259 2168864 Positive_regulation MMP7 TLR9 24959259 2168865 Positive_regulation MMP7 TMED7 23785669 945531 Positive_regulation MMP7 TNC 21818551 600162 Positive_regulation MMP7 TNF 14979937 100175 Positive_regulation MMP7 TNF 15987479 103921 Positive_regulation MMP7 TNF 17118171 3096366 Positive_regulation MMP7 TNF 18237379 379299 Positive_regulation MMP7 TNF 19226472 112880 Positive_regulation MMP7 TNF 19281072 1071680 Positive_regulation MMP7 TNF 19435506 113275 Positive_regulation MMP7 TNF 19889233 3097680 Positive_regulation MMP7 TNF 20126546 2439128 Positive_regulation MMP7 TNF 20126546 2439175 Positive_regulation MMP7 TNF 20543948 2452507 Positive_regulation MMP7 TNF 20871770 1047111 Positive_regulation MMP7 TNF 21912722 2223891 Positive_regulation MMP7 TNF 22005011 1697951 Positive_regulation MMP7 TNF 22315682 1687136 Positive_regulation MMP7 TNF 22500233 154797 Positive_regulation MMP7 TNF 22778767 636648 Positive_regulation MMP7 TNF 23441116 1915741 Positive_regulation MMP7 TNF 23533687 2225611 Positive_regulation MMP7 TNF 23924945 1109787 Positive_regulation MMP7 TNF 24236107 2878558 Positive_regulation MMP7 TNF 24278882 1498608 Positive_regulation MMP7 TNF 24762063 401044 Positive_regulation MMP7 TNF 24926361 844477 Positive_regulation MMP7 TNF 24977073 1154333 Positive_regulation MMP7 TNF 25143751 645573 Positive_regulation MMP7 TNF 25147435 1761218 Positive_regulation MMP7 TNF 25250141 1148972 Positive_regulation MMP7 TNF 25356505 1133374 Positive_regulation MMP7 TNFRSF11B 23340891 730021 Positive_regulation MMP7 TNFSF11 24978435 504735 Positive_regulation MMP7 TNFSF11 24978435 504743 Positive_regulation MMP7 TP53 18516228 3041418 Positive_regulation MMP7 TRNAE1 20418905 2129666 Positive_regulation MMP7 TRNAE1 20418905 2129667 Positive_regulation MMP7 TRNAE1 20418905 2129668 Positive_regulation MMP7 TRNAE1 20418905 2129669 Positive_regulation MMP7 TRNAE1 20418905 2131807 Positive_regulation MMP7 TRPV1 25205949 90092 Positive_regulation MMP7 TSPAN1 23840773 2817312 Positive_regulation MMP7 TSPAN10 23840773 2817321 Positive_regulation MMP7 TSPAN11 23840773 2817323 Positive_regulation MMP7 TSPAN12 23840773 2817316 Positive_regulation MMP7 TSPAN13 23840773 2817317 Positive_regulation MMP7 TSPAN14 23840773 2817319 Positive_regulation MMP7 TSPAN15 23840773 2817318 Positive_regulation MMP7 TSPAN16 23840773 2817322 Positive_regulation MMP7 TSPAN17 23840773 2817309 Positive_regulation MMP7 TSPAN18 23840773 2817314 Positive_regulation MMP7 TSPAN19 23840773 2817324 Positive_regulation MMP7 TSPAN2 23840773 2817313 Positive_regulation MMP7 TSPAN3 23840773 2817310 Positive_regulation MMP7 TSPAN31 23840773 2817303 Positive_regulation MMP7 TSPAN32 23840773 2817308 Positive_regulation MMP7 TSPAN33 23840773 2817320 Positive_regulation MMP7 TSPAN4 23840773 2817307 Positive_regulation MMP7 TSPAN5 23840773 2817311 Positive_regulation MMP7 TSPAN6 23840773 2817306 Positive_regulation MMP7 TSPAN7 23840773 2817304 Positive_regulation MMP7 TSPAN8 23840773 2817305 Positive_regulation MMP7 TSPAN9 23840773 2817315 Positive_regulation MMP7 TWIST1 22891766 245290 Positive_regulation MMP7 UCP2 17472436 2262924 Positive_regulation MMP7 UCP2 17472436 2262990 Positive_regulation MMP7 UCP2 23210978 3188331 Positive_regulation MMP7 USP1 20418905 2131808 Positive_regulation MMP7 USP10 20418905 2131809 Positive_regulation MMP7 USP11 20418905 2131810 Positive_regulation MMP7 USP12 20418905 2131853 Positive_regulation MMP7 USP13 20418905 2131811 Positive_regulation MMP7 USP14 20418905 2131812 Positive_regulation MMP7 USP15 20418905 2131813 Positive_regulation MMP7 USP16 20418905 2131814 Positive_regulation MMP7 USP18 20418905 2131815 Positive_regulation MMP7 USP19 20418905 2131816 Positive_regulation MMP7 USP2 20418905 2131817 Positive_regulation MMP7 USP20 20418905 2131818 Positive_regulation MMP7 USP21 20418905 2131819 Positive_regulation MMP7 USP22 20418905 2131820 Positive_regulation MMP7 USP24 20418905 2131821 Positive_regulation MMP7 USP25 20418905 2131822 Positive_regulation MMP7 USP26 20418905 2131830 Positive_regulation MMP7 USP28 20418905 2131823 Positive_regulation MMP7 USP29 20418905 2131832 Positive_regulation MMP7 USP3 20418905 2131824 Positive_regulation MMP7 USP30 20418905 2131840 Positive_regulation MMP7 USP31 20418905 2131835 Positive_regulation MMP7 USP32 20418905 2131833 Positive_regulation MMP7 USP33 20418905 2131834 Positive_regulation MMP7 USP34 20418905 2131841 Positive_regulation MMP7 USP35 20418905 2131836 Positive_regulation MMP7 USP36 20418905 2131837 Positive_regulation MMP7 USP37 20418905 2131838 Positive_regulation MMP7 USP38 20418905 2131842 Positive_regulation MMP7 USP39 20418905 2131846 Positive_regulation MMP7 USP4 20418905 2131825 Positive_regulation MMP7 USP40 20418905 2131844 Positive_regulation MMP7 USP41 20418905 2131845 Positive_regulation MMP7 USP42 20418905 2131843 Positive_regulation MMP7 USP43 20418905 2131847 Positive_regulation MMP7 USP44 20418905 2131839 Positive_regulation MMP7 USP45 20418905 2131852 Positive_regulation MMP7 USP46 20418905 2131848 Positive_regulation MMP7 USP47 20418905 2131849 Positive_regulation MMP7 USP48 20418905 2131831 Positive_regulation MMP7 USP49 20418905 2131850 Positive_regulation MMP7 USP5 20418905 2131826 Positive_regulation MMP7 USP50 20418905 2131851 Positive_regulation MMP7 USP51 20418905 2131854 Positive_regulation MMP7 USP53 20418905 2131856 Positive_regulation MMP7 USP54 20418905 2131855 Positive_regulation MMP7 USP6 20418905 2131827 Positive_regulation MMP7 USP7 20418905 2131828 Positive_regulation MMP7 USP8 20418905 2131829 Positive_regulation MMP7 UTRN 22438978 2612512 Positive_regulation MMP7 VCAM1 25525444 827408 Positive_regulation MMP7 VEGFA 21193734 717000 Positive_regulation MMP7 VEGFA 21349159 3206880 Positive_regulation MMP7 VEGFA 21349159 3207066 Positive_regulation MMP7 VEGFA 21559216 3128178 Positive_regulation MMP7 VEGFA 22044497 3165514 Positive_regulation MMP7 VEGFA 22206448 6661 Positive_regulation MMP7 VEGFA 23161900 91243 Positive_regulation MMP7 VEGFA 23552472 1506830 Positive_regulation MMP7 VEGFA 24641672 3114524 Positive_regulation MMP7 VEGFA 25257525 1131092 Positive_regulation MMP7 VEGFA 8554978 445215 Positive_regulation MMP7 VNN1 22720042 2654283 Positive_regulation MMP7 WISP2 14636425 523461 Positive_regulation MMP7 WNT1 16438732 3106224 Positive_regulation MMP7 WNT1 20565841 3110697 Positive_regulation MMP7 WNT1 23965253 129250 Positive_regulation MMP7 WNT1 23965253 129562 Positive_regulation MMP7 WNT1 25360795 3021579 Positive_regulation MMP7 WNT11 16438732 3106225 Positive_regulation MMP7 WNT11 20565841 3110698 Positive_regulation MMP7 WNT11 23965253 129251 Positive_regulation MMP7 WNT11 23965253 129563 Positive_regulation MMP7 WNT11 25360795 3021580 Positive_regulation MMP7 WNT16 16438732 3106230 Positive_regulation MMP7 WNT16 20565841 3110703 Positive_regulation MMP7 WNT16 23965253 129256 Positive_regulation MMP7 WNT16 23965253 129568 Positive_regulation MMP7 WNT16 25360795 3021585 Positive_regulation MMP7 WNT2 16438732 3106226 Positive_regulation MMP7 WNT2 20565841 3110699 Positive_regulation MMP7 WNT2 23965253 129252 Positive_regulation MMP7 WNT2 23965253 129564 Positive_regulation MMP7 WNT2 25360795 3021581 Positive_regulation MMP7 WNT3 16438732 3106227 Positive_regulation MMP7 WNT3 20565841 3110700 Positive_regulation MMP7 WNT3 23965253 129253 Positive_regulation MMP7 WNT3 23965253 129565 Positive_regulation MMP7 WNT3 25360795 3021582 Positive_regulation MMP7 WNT3A 24479426 131534 Positive_regulation MMP7 WNT4 16438732 3106228 Positive_regulation MMP7 WNT4 20565841 3110701 Positive_regulation MMP7 WNT4 23965253 129254 Positive_regulation MMP7 WNT4 23965253 129566 Positive_regulation MMP7 WNT4 25360795 3021583 Positive_regulation MMP7 WNT5A 23484019 2765106 Positive_regulation MMP7 WNT5A 24757147 135790 Positive_regulation MMP7 WNT6 16438732 3106229 Positive_regulation MMP7 WNT6 20565841 3110702 Positive_regulation MMP7 WNT6 23965253 129255 Positive_regulation MMP7 WNT6 23965253 129567 Positive_regulation MMP7 WNT6 25360795 3021584 Positive_regulation MMP7 WNT7A 24479426 131533 Positive_regulation MMP7 XIAP 24336521 1820033 Positive_regulation MMP8 AGR2 17129374 107141 Positive_regulation MMP8 AGR2 17129374 107142 Positive_regulation MMP8 CAPN8 18493299 2389176 Positive_regulation MMP8 CAPN8 21911754 720281 Positive_regulation MMP8 CCND1 22942717 1097103 Positive_regulation MMP8 EPHB2 18629305 793180 Positive_regulation MMP8 EPHB2 21738525 922812 Positive_regulation MMP8 EPHB2 22310287 2146216 Positive_regulation MMP8 EPHB2 23663277 1678792 Positive_regulation MMP8 EPHB2 23671446 95703 Positive_regulation MMP8 EPHB2 24084727 1113161 Positive_regulation MMP8 GPR115 24066041 2850578 Positive_regulation MMP8 GPR132 24066041 2850567 Positive_regulation MMP8 GPR87 24066041 2850647 Positive_regulation MMP8 HBEGF 21179550 2489223 Positive_regulation MMP8 IL1B 15203568 1739677 Positive_regulation MMP8 MAP2K6 20667128 1857648 Positive_regulation MMP8 MIP 21347304 2503612 Positive_regulation MMP8 MMP7 24273653 2251312 Positive_regulation MMP8 MMP7 24519465 2243676 Positive_regulation MMP8 MUC16 23694968 3135803 Positive_regulation MMP8 PECAM1 12591918 1291200 Positive_regulation MMP8 PLAT 23977299 2839958 Positive_regulation MMP8 PLAT 24303218 2003303 Positive_regulation MMP8 PLAU 24189182 787878 Positive_regulation MMP8 PLAU 9083329 446132 Positive_regulation MMP8 TFPI2 23905012 853461 Positive_regulation MMP8 TFPI2 PMC2756345 496100 Positive_regulation MMP8 TGM2 24130925 204519 Positive_regulation MMP8 TLR7 17129374 107370 Positive_regulation MMP8 TLR7 23940584 2831826 Positive_regulation MMP8 TNF 14979937 100176 Positive_regulation MMP8 TNF 15987479 103923 Positive_regulation MMP8 TNF 17118171 3096367 Positive_regulation MMP8 TNF 18237379 379300 Positive_regulation MMP8 TNF 19226472 112884 Positive_regulation MMP8 TNF 19281072 1071681 Positive_regulation MMP8 TNF 19435506 113276 Positive_regulation MMP8 TNF 19889233 3097681 Positive_regulation MMP8 TNF 20126546 2439129 Positive_regulation MMP8 TNF 20126546 2439176 Positive_regulation MMP8 TNF 20543948 2452509 Positive_regulation MMP8 TNF 20871770 1047112 Positive_regulation MMP8 TNF 21912722 2223892 Positive_regulation MMP8 TNF 22005011 1697952 Positive_regulation MMP8 TNF 22315682 1687137 Positive_regulation MMP8 TNF 22500233 154798 Positive_regulation MMP8 TNF 22623923 900935 Positive_regulation MMP8 TNF 22778767 636649 Positive_regulation MMP8 TNF 23441116 1915742 Positive_regulation MMP8 TNF 23533687 2225612 Positive_regulation MMP8 TNF 23924945 1109788 Positive_regulation MMP8 TNF 24236107 2878560 Positive_regulation MMP8 TNF 24278882 1498609 Positive_regulation MMP8 TNF 24683547 187705 Positive_regulation MMP8 TNF 24762063 401045 Positive_regulation MMP8 TNF 24926361 844489 Positive_regulation MMP8 TNF 24977073 1154336 Positive_regulation MMP8 TNF 25143751 645576 Positive_regulation MMP8 TNF 25147435 1761219 Positive_regulation MMP8 TNF 25250141 1148973 Positive_regulation MMP8 TNF 25356505 1133382 Positive_regulation MMP8 TSPAN1 23840773 2817334 Positive_regulation MMP8 WNT7A 24479426 131535 Positive_regulation MMP9 AGR2 17129374 107145 Positive_regulation MMP9 AGR2 17129374 107146 Positive_regulation MMP9 CAPN8 18493299 2389190 Positive_regulation MMP9 CAPN8 21911754 720296 Positive_regulation MMP9 CAPN8 21911754 720381 Positive_regulation MMP9 CCND1 22942717 1097104 Positive_regulation MMP9 CCND1 23383271 2749843 Positive_regulation MMP9 CCND1 24552536 1871821 Positive_regulation MMP9 CD14 22174822 2582295 Positive_regulation MMP9 CEACAM6 15316565 424909 Positive_regulation MMP9 CEACAM6 25398131 3027594 Positive_regulation MMP9 CHI3L1 23071724 2703779 Positive_regulation MMP9 CHI3L1 23533311 1751824 Positive_regulation MMP9 CHI3L1 24399973 963260 Positive_regulation MMP9 CHI3L1 24399973 963267 Positive_regulation MMP9 CHI3L1 24729664 1758064 Positive_regulation MMP9 CHI3L1 24729664 1758081 Positive_regulation MMP9 CLU 24672247 2122902 Positive_regulation MMP9 CLU 25574066 738619 Positive_regulation MMP9 CTGF 19922639 117874 Positive_regulation MMP9 CTGF 23755163 2801561 Positive_regulation MMP9 CTGF 24733089 2952616 Positive_regulation MMP9 EPHB2 12865932 422940 Positive_regulation MMP9 EPHB2 18629305 793183 Positive_regulation MMP9 EPHB2 20107538 1037436 Positive_regulation MMP9 EPHB2 20107538 1037460 Positive_regulation MMP9 EPHB2 20847954 1747922 Positive_regulation MMP9 EPHB2 21249198 2493276 Positive_regulation MMP9 EPHB2 21738525 922813 Positive_regulation MMP9 EPHB2 21738655 2533186 Positive_regulation MMP9 EPHB2 22310287 2146217 Positive_regulation MMP9 EPHB2 22413009 2610079 Positive_regulation MMP9 EPHB2 23139770 2713872 Positive_regulation MMP9 EPHB2 23451269 2758485 Positive_regulation MMP9 EPHB2 23663277 1678794 Positive_regulation MMP9 EPHB2 23671446 95717 Positive_regulation MMP9 EPHB2 23873298 1108849 Positive_regulation MMP9 EPHB2 24084727 1113163 Positive_regulation MMP9 EPHB2 24132149 1113450 Positive_regulation MMP9 EPHB2 24205091 2875319 Positive_regulation MMP9 EPHB2 24348851 2167462 Positive_regulation MMP9 EPHB2 24504172 2187106 Positive_regulation MMP9 EPHB2 24504172 2187107 Positive_regulation MMP9 EPHB2 24504172 2187111 Positive_regulation MMP9 EPHB2 25375189 1133763 Positive_regulation MMP9 EPHB2 25499743 476596 Positive_regulation MMP9 EPHB2 25499743 476670 Positive_regulation MMP9 F2R 21439035 1658051 Positive_regulation MMP9 FAS 16316466 383092 Positive_regulation MMP9 FAS 16316466 383095 Positive_regulation MMP9 FUT4 23887626 564172 Positive_regulation MMP9 GPR115 24066041 2850671 Positive_regulation MMP9 GPR132 24066041 2850660 Positive_regulation MMP9 GPR87 24066041 2850740 Positive_regulation MMP9 HBEGF 21179550 2489225 Positive_regulation MMP9 HBEGF 22209887 2170767 Positive_regulation MMP9 HBEGF 22209887 2170769 Positive_regulation MMP9 ID1 24970809 2193989 Positive_regulation MMP9 IL1B 12061424 1738147 Positive_regulation MMP9 IL1B 15203568 1739678 Positive_regulation MMP9 IL1B 22432004 2611482 Positive_regulation MMP9 IL1B 23717664 2798677 Positive_regulation MMP9 IL1B 23717664 2798678 Positive_regulation MMP9 IL1B 23717664 2798679 Positive_regulation MMP9 IL1B 23717664 2798685 Positive_regulation MMP9 IL1B 23717664 2798686 Positive_regulation MMP9 IL1B 23922722 2826282 Positive_regulation MMP9 IL1B 23922722 2826288 Positive_regulation MMP9 IL1B 24298256 953383 Positive_regulation MMP9 ITGB2 11097210 702112 Positive_regulation MMP9 LGALS7B 23985992 2184710 Positive_regulation MMP9 LGALS7B 24515895 492441 Positive_regulation MMP9 MAP2K6 20667128 1857656 Positive_regulation MMP9 MAP2K6 23139770 2713878 Positive_regulation MMP9 MAP2K6 24013225 2153526 Positive_regulation MMP9 MIP 21347304 2503613 Positive_regulation MMP9 MMP28 19653123 1832112 Positive_regulation MMP9 MMP28 20396502 1491950 Positive_regulation MMP9 MMP28 21118526 2111632 Positive_regulation MMP9 MMP28 21787393 229552 Positive_regulation MMP9 MMP28 23199061 804568 Positive_regulation MMP9 MMP28 23614111 647236 Positive_regulation MMP9 MMP28 24473089 502814 Positive_regulation MMP9 MMP28 24821912 1576231 Positive_regulation MMP9 MMP28 PMC4075544 350095 Positive_regulation MMP9 MMP7 19653123 1832127 Positive_regulation MMP9 MMP7 20396502 1491965 Positive_regulation MMP9 MMP7 21118526 2111647 Positive_regulation MMP9 MMP7 21455784 2012507 Positive_regulation MMP9 MMP7 21490792 1683277 Positive_regulation MMP9 MMP7 21787393 229567 Positive_regulation MMP9 MMP7 22400063 3177211 Positive_regulation MMP9 MMP7 23199061 804583 Positive_regulation MMP9 MMP7 23614111 647251 Positive_regulation MMP9 MMP7 23984338 183384 Positive_regulation MMP9 MMP7 24473089 502830 Positive_regulation MMP9 MMP7 24519465 2243678 Positive_regulation MMP9 MMP7 24821912 1576246 Positive_regulation MMP9 MMP7 25107295 647575 Positive_regulation MMP9 MMP7 PMC4075544 350111 Positive_regulation MMP9 MUC16 23694968 3135804 Positive_regulation MMP9 PECAM1 12591918 1291201 Positive_regulation MMP9 PGC 17987121 2380293 Positive_regulation MMP9 PLAT 18332222 1350060 Positive_regulation MMP9 PLAT 20396502 1491945 Positive_regulation MMP9 PLAT 20396502 1491968 Positive_regulation MMP9 PLAT 20406488 328839 Positive_regulation MMP9 PLAT 21569344 1697245 Positive_regulation MMP9 PLAT 21569344 1697247 Positive_regulation MMP9 PLAT 21799677 812960 Positive_regulation MMP9 PLAT 23565108 935254 Positive_regulation MMP9 PLAT 23565108 935269 Positive_regulation MMP9 PLAT 23565108 935274 Positive_regulation MMP9 PLAT 23565108 935333 Positive_regulation MMP9 PLAT 23565108 935334 Positive_regulation MMP9 PLAT 23565108 935340 Positive_regulation MMP9 PLAT 23565108 935341 Positive_regulation MMP9 PLAT 23565108 935343 Positive_regulation MMP9 PLAT 23977299 2839910 Positive_regulation MMP9 PLAT 23977299 2839959 Positive_regulation MMP9 PLAT 24026771 1890418 Positive_regulation MMP9 PLAT 24303218 2003304 Positive_regulation MMP9 PLAT 24885160 1668110 Positive_regulation MMP9 PLAT 25407528 1134466 Positive_regulation MMP9 PLAT 25514242 1135685 Positive_regulation MMP9 PLAU 12865932 422941 Positive_regulation MMP9 PLAU 16901352 232376 Positive_regulation MMP9 PLAU 19820721 8271 Positive_regulation MMP9 PLAU 21347260 2503466 Positive_regulation MMP9 PLAU 21799677 812961 Positive_regulation MMP9 PLAU 24189182 787879 Positive_regulation MMP9 PLAU 25222667 1730977 Positive_regulation MMP9 PLAU 9083329 446134 Positive_regulation MMP9 PODXL 23596468 843110 Positive_regulation MMP9 S100A7 23618129 3226592 Positive_regulation MMP9 S100A7 23618129 3226593 Positive_regulation MMP9 S100A7 23618129 3226602 Positive_regulation MMP9 S100A7 23618129 3226603 Positive_regulation MMP9 S100A7 23618129 3226606 Positive_regulation MMP9 SELL 11097210 702110 Positive_regulation MMP9 SRGN 21880179 623904 Positive_regulation MMP9 TFPI2 23905012 853462 Positive_regulation MMP9 TFPI2 PMC2756345 496102 Positive_regulation MMP9 TGM2 24130925 204478 Positive_regulation MMP9 TGM2 24130925 204479 Positive_regulation MMP9 TGM2 24130925 204480 Positive_regulation MMP9 TGM2 24130925 204486 Positive_regulation MMP9 TGM2 24130925 204490 Positive_regulation MMP9 TGM2 24130925 204495 Positive_regulation MMP9 TGM2 24130925 204496 Positive_regulation MMP9 TGM2 24130925 204520 Positive_regulation MMP9 TLR7 17129374 107380 Positive_regulation MMP9 TLR7 22496659 3056164 Positive_regulation MMP9 TLR7 23940584 2831836 Positive_regulation MMP9 TNF 11132772 1737228 Positive_regulation MMP9 TNF 11132772 1737232 Positive_regulation MMP9 TNF 11132772 1737237 Positive_regulation MMP9 TNF 11686853 389895 Positive_regulation MMP9 TNF 12061424 1738146 Positive_regulation MMP9 TNF 12516548 2001313 Positive_regulation MMP9 TNF 14651749 3095624 Positive_regulation MMP9 TNF 14651749 3095629 Positive_regulation MMP9 TNF 14651749 3095635 Positive_regulation MMP9 TNF 14712829 2001517 Positive_regulation MMP9 TNF 14979937 100177 Positive_regulation MMP9 TNF 14979937 100182 Positive_regulation MMP9 TNF 15642145 102409 Positive_regulation MMP9 TNF 15642145 102411 Positive_regulation MMP9 TNF 15987479 103925 Positive_regulation MMP9 TNF 16106101 1740044 Positive_regulation MMP9 TNF 16153299 3105649 Positive_regulation MMP9 TNF 16316466 383090 Positive_regulation MMP9 TNF 16316466 383094 Positive_regulation MMP9 TNF 17118171 3096368 Positive_regulation MMP9 TNF 18001502 109449 Positive_regulation MMP9 TNF 18057520 736044 Positive_regulation MMP9 TNF 18237379 379301 Positive_regulation MMP9 TNF 19226472 112888 Positive_regulation MMP9 TNF 19281072 1071682 Positive_regulation MMP9 TNF 19281093 1071725 Positive_regulation MMP9 TNF 19287485 2408006 Positive_regulation MMP9 TNF 19298660 352660 Positive_regulation MMP9 TNF 19298660 352661 Positive_regulation MMP9 TNF 19298660 352662 Positive_regulation MMP9 TNF 19298660 352663 Positive_regulation MMP9 TNF 19298660 352683 Positive_regulation MMP9 TNF 19298660 352779 Positive_regulation MMP9 TNF 19435506 113277 Positive_regulation MMP9 TNF 19435506 113278 Positive_regulation MMP9 TNF 19889233 3097682 Positive_regulation MMP9 TNF 20126546 2439130 Positive_regulation MMP9 TNF 20126546 2439177 Positive_regulation MMP9 TNF 20181828 1774627 Positive_regulation MMP9 TNF 20429888 118783 Positive_regulation MMP9 TNF 20543948 2452511 Positive_regulation MMP9 TNF 20642847 1727990 Positive_regulation MMP9 TNF 20642847 1727991 Positive_regulation MMP9 TNF 20642847 1727994 Positive_regulation MMP9 TNF 20843335 1626170 Positive_regulation MMP9 TNF 20862369 1747964 Positive_regulation MMP9 TNF 20871770 1047113 Positive_regulation MMP9 TNF 21052539 632108 Positive_regulation MMP9 TNF 21067565 397470 Positive_regulation MMP9 TNF 21067565 397480 Positive_regulation MMP9 TNF 21320340 259172 Positive_regulation MMP9 TNF 21747731 1091437 Positive_regulation MMP9 TNF 21747731 1091438 Positive_regulation MMP9 TNF 21747731 1091444 Positive_regulation MMP9 TNF 21747731 1091445 Positive_regulation MMP9 TNF 21747731 1091451 Positive_regulation MMP9 TNF 21747731 1091452 Positive_regulation MMP9 TNF 21747731 1091454 Positive_regulation MMP9 TNF 21747731 1091457 Positive_regulation MMP9 TNF 21747731 1091458 Positive_regulation MMP9 TNF 21760774 979881 Positive_regulation MMP9 TNF 21799681 812962 Positive_regulation MMP9 TNF 21799681 812965 Positive_regulation MMP9 TNF 21867555 1659541 Positive_regulation MMP9 TNF 21867555 1659542 Positive_regulation MMP9 TNF 21867555 1659543 Positive_regulation MMP9 TNF 21867555 1659544 Positive_regulation MMP9 TNF 21867555 1659545 Positive_regulation MMP9 TNF 21867555 1659546 Positive_regulation MMP9 TNF 21867555 1659547 Positive_regulation MMP9 TNF 21867555 1659548 Positive_regulation MMP9 TNF 21867555 1659549 Positive_regulation MMP9 TNF 21867555 1659561 Positive_regulation MMP9 TNF 21867555 1659562 Positive_regulation MMP9 TNF 21867555 1659563 Positive_regulation MMP9 TNF 21867555 1659566 Positive_regulation MMP9 TNF 21867555 1659567 Positive_regulation MMP9 TNF 21867555 1659568 Positive_regulation MMP9 TNF 21867555 1659569 Positive_regulation MMP9 TNF 21867555 1659588 Positive_regulation MMP9 TNF 21867555 1659589 Positive_regulation MMP9 TNF 21867555 1659596 Positive_regulation MMP9 TNF 21867555 1659604 Positive_regulation MMP9 TNF 21867555 1659605 Positive_regulation MMP9 TNF 21867555 1659608 Positive_regulation MMP9 TNF 21867555 1659609 Positive_regulation MMP9 TNF 21912722 2223893 Positive_regulation MMP9 TNF 21999923 3112795 Positive_regulation MMP9 TNF 21999923 3112799 Positive_regulation MMP9 TNF 22005011 1697953 Positive_regulation MMP9 TNF 22069489 2569151 Positive_regulation MMP9 TNF 22069489 2569189 Positive_regulation MMP9 TNF 22069489 2569227 Positive_regulation MMP9 TNF 22069489 2569235 Positive_regulation MMP9 TNF 22144827 1675239 Positive_regulation MMP9 TNF 22315682 1687138 Positive_regulation MMP9 TNF 22353423 1661080 Positive_regulation MMP9 TNF 22353423 1661081 Positive_regulation MMP9 TNF 22353423 1661114 Positive_regulation MMP9 TNF 22353423 1661139 Positive_regulation MMP9 TNF 22353423 1661167 Positive_regulation MMP9 TNF 22353423 1661169 Positive_regulation MMP9 TNF 22363757 2601798 Positive_regulation MMP9 TNF 22393384 2608056 Positive_regulation MMP9 TNF 22403544 950945 Positive_regulation MMP9 TNF 22426696 14549 Positive_regulation MMP9 TNF 22455954 125288 Positive_regulation MMP9 TNF 22500233 154799 Positive_regulation MMP9 TNF 22523502 1156190 Positive_regulation MMP9 TNF 22570756 1024158 Positive_regulation MMP9 TNF 22623923 900936 Positive_regulation MMP9 TNF 22778767 636650 Positive_regulation MMP9 TNF 22811589 1750131 Positive_regulation MMP9 TNF 22811589 1750132 Positive_regulation MMP9 TNF 22899878 1750195 Positive_regulation MMP9 TNF 22899878 1750210 Positive_regulation MMP9 TNF 23072510 127030 Positive_regulation MMP9 TNF 23139770 2713896 Positive_regulation MMP9 TNF 23341882 2741316 Positive_regulation MMP9 TNF 23341882 2741322 Positive_regulation MMP9 TNF 23437179 2755928 Positive_regulation MMP9 TNF 23441116 1915743 Positive_regulation MMP9 TNF 23533687 2225613 Positive_regulation MMP9 TNF 23587438 1666180 Positive_regulation MMP9 TNF 23587438 1666181 Positive_regulation MMP9 TNF 23587438 1666182 Positive_regulation MMP9 TNF 23587438 1666498 Positive_regulation MMP9 TNF 23587438 1666543 Positive_regulation MMP9 TNF 23675440 2792962 Positive_regulation MMP9 TNF 23840095 1753416 Positive_regulation MMP9 TNF 23840100 1753484 Positive_regulation MMP9 TNF 23861949 2821006 Positive_regulation MMP9 TNF 23894351 2824228 Positive_regulation MMP9 TNF 23924945 1109789 Positive_regulation MMP9 TNF 24016040 294971 Positive_regulation MMP9 TNF 24026771 1890402 Positive_regulation MMP9 TNF 24085323 1142197 Positive_regulation MMP9 TNF 24085323 1142198 Positive_regulation MMP9 TNF 24085323 1142199 Positive_regulation MMP9 TNF 24085323 1142200 Positive_regulation MMP9 TNF 24085323 1142225 Positive_regulation MMP9 TNF 24085323 1142228 Positive_regulation MMP9 TNF 24085323 1142229 Positive_regulation MMP9 TNF 24190483 1142423 Positive_regulation MMP9 TNF 24205091 2875305 Positive_regulation MMP9 TNF 24223987 2877540 Positive_regulation MMP9 TNF 24236107 2878562 Positive_regulation MMP9 TNF 24270905 453552 Positive_regulation MMP9 TNF 24270905 453554 Positive_regulation MMP9 TNF 24278749 3150631 Positive_regulation MMP9 TNF 24278882 1498610 Positive_regulation MMP9 TNF 24285913 737688 Positive_regulation MMP9 TNF 24298256 953382 Positive_regulation MMP9 TNF 24397824 1232873 Positive_regulation MMP9 TNF 24495480 131698 Positive_regulation MMP9 TNF 24502696 1232962 Positive_regulation MMP9 TNF 24502696 1232963 Positive_regulation MMP9 TNF 24502696 1232964 Positive_regulation MMP9 TNF 24502696 1232965 Positive_regulation MMP9 TNF 24502696 1232966 Positive_regulation MMP9 TNF 24502696 1232967 Positive_regulation MMP9 TNF 24502696 1232968 Positive_regulation MMP9 TNF 24502696 1232969 Positive_regulation MMP9 TNF 24502696 1232970 Positive_regulation MMP9 TNF 24502696 1232971 Positive_regulation MMP9 TNF 24502696 1232972 Positive_regulation MMP9 TNF 24502696 1232973 Positive_regulation MMP9 TNF 24502696 1232974 Positive_regulation MMP9 TNF 24502696 1232975 Positive_regulation MMP9 TNF 24502696 1232976 Positive_regulation MMP9 TNF 24502696 1232977 Positive_regulation MMP9 TNF 24502696 1232978 Positive_regulation MMP9 TNF 24502696 1232979 Positive_regulation MMP9 TNF 24502696 1233023 Positive_regulation MMP9 TNF 24502696 1233024 Positive_regulation MMP9 TNF 24502696 1233025 Positive_regulation MMP9 TNF 24502696 1233026 Positive_regulation MMP9 TNF 24502696 1233050 Positive_regulation MMP9 TNF 24502696 1233051 Positive_regulation MMP9 TNF 24502696 1233052 Positive_regulation MMP9 TNF 24502696 1233053 Positive_regulation MMP9 TNF 24502696 1233073 Positive_regulation MMP9 TNF 24502696 1233074 Positive_regulation MMP9 TNF 24502696 1233075 Positive_regulation MMP9 TNF 24502696 1233076 Positive_regulation MMP9 TNF 24502696 1233132 Positive_regulation MMP9 TNF 24502696 1233133 Positive_regulation MMP9 TNF 24502696 1233134 Positive_regulation MMP9 TNF 24502696 1233135 Positive_regulation MMP9 TNF 24502696 1233136 Positive_regulation MMP9 TNF 24502696 1233137 Positive_regulation MMP9 TNF 24502696 1233138 Positive_regulation MMP9 TNF 24502696 1233139 Positive_regulation MMP9 TNF 24502696 1233179 Positive_regulation MMP9 TNF 24502696 1233180 Positive_regulation MMP9 TNF 24502696 1233181 Positive_regulation MMP9 TNF 24502696 1233182 Positive_regulation MMP9 TNF 24502696 1233183 Positive_regulation MMP9 TNF 24502696 1233190 Positive_regulation MMP9 TNF 24502696 1233191 Positive_regulation MMP9 TNF 24502696 1233192 Positive_regulation MMP9 TNF 24502696 1233193 Positive_regulation MMP9 TNF 24502696 1233194 Positive_regulation MMP9 TNF 24502696 1233230 Positive_regulation MMP9 TNF 24502696 1233231 Positive_regulation MMP9 TNF 24502696 1233232 Positive_regulation MMP9 TNF 24502696 1233233 Positive_regulation MMP9 TNF 24502696 1233234 Positive_regulation MMP9 TNF 24502696 1233235 Positive_regulation MMP9 TNF 24502696 1233236 Positive_regulation MMP9 TNF 24502696 1233281 Positive_regulation MMP9 TNF 24502696 1233282 Positive_regulation MMP9 TNF 24502696 1233283 Positive_regulation MMP9 TNF 24502696 1233284 Positive_regulation MMP9 TNF 24502696 1233285 Positive_regulation MMP9 TNF 24502696 1233303 Positive_regulation MMP9 TNF 24502696 1233304 Positive_regulation MMP9 TNF 24502696 1233305 Positive_regulation MMP9 TNF 24502696 1233306 Positive_regulation MMP9 TNF 24502696 1233307 Positive_regulation MMP9 TNF 24502696 1233313 Positive_regulation MMP9 TNF 24502696 1233314 Positive_regulation MMP9 TNF 24502696 1233333 Positive_regulation MMP9 TNF 24502696 1233334 Positive_regulation MMP9 TNF 24502696 1233335 Positive_regulation MMP9 TNF 24502696 1233336 Positive_regulation MMP9 TNF 24502696 1233355 Positive_regulation MMP9 TNF 24502696 1233356 Positive_regulation MMP9 TNF 24502696 1233357 Positive_regulation MMP9 TNF 24502696 1233358 Positive_regulation MMP9 TNF 24502696 1233365 Positive_regulation MMP9 TNF 24502696 1233366 Positive_regulation MMP9 TNF 24502696 1233367 Positive_regulation MMP9 TNF 24502696 1233368 Positive_regulation MMP9 TNF 24502696 1233373 Positive_regulation MMP9 TNF 24502696 1233378 Positive_regulation MMP9 TNF 24552146 295810 Positive_regulation MMP9 TNF 24552146 295822 Positive_regulation MMP9 TNF 24552146 295834 Positive_regulation MMP9 TNF 24552146 295845 Positive_regulation MMP9 TNF 24552146 295846 Positive_regulation MMP9 TNF 24552146 295847 Positive_regulation MMP9 TNF 24552146 295849 Positive_regulation MMP9 TNF 24552146 295850 Positive_regulation MMP9 TNF 24552146 295853 Positive_regulation MMP9 TNF 24552146 295855 Positive_regulation MMP9 TNF 24586879 2927852 Positive_regulation MMP9 TNF 24618693 2933257 Positive_regulation MMP9 TNF 24762063 401046 Positive_regulation MMP9 TNF 24798452 2960726 Positive_regulation MMP9 TNF 24824968 2969533 Positive_regulation MMP9 TNF 24861337 653717 Positive_regulation MMP9 TNF 24864265 191756 Positive_regulation MMP9 TNF 24876677 1758978 Positive_regulation MMP9 TNF 24885494 396639 Positive_regulation MMP9 TNF 24926361 844501 Positive_regulation MMP9 TNF 24977073 1154339 Positive_regulation MMP9 TNF 24978432 504546 Positive_regulation MMP9 TNF 24993803 734648 Positive_regulation MMP9 TNF 25009774 3094525 Positive_regulation MMP9 TNF 25049453 1760215 Positive_regulation MMP9 TNF 25076423 2993183 Positive_regulation MMP9 TNF 25134539 1883934 Positive_regulation MMP9 TNF 25134539 1883935 Positive_regulation MMP9 TNF 25134539 1883937 Positive_regulation MMP9 TNF 25134539 1883938 Positive_regulation MMP9 TNF 25143751 645579 Positive_regulation MMP9 TNF 25147435 1761220 Positive_regulation MMP9 TNF 25205949 90099 Positive_regulation MMP9 TNF 25237378 3204858 Positive_regulation MMP9 TNF 25250141 1148974 Positive_regulation MMP9 TNF 25356505 1133389 Positive_regulation MMP9 TNF 25385232 3146858 Positive_regulation MMP9 TNF 25393535 2373163 Positive_regulation MMP9 TNF 25393535 2373164 Positive_regulation MMP9 TNF 25393535 2373165 Positive_regulation MMP9 TNF 25393535 2373168 Positive_regulation MMP9 TNF 25393535 2373171 Positive_regulation MMP9 TNF 25393535 2373172 Positive_regulation MMP9 TNF 25426024 872205 Positive_regulation MMP9 TNF 25470819 3032060 Positive_regulation MMP9 TNF 25470819 3032065 Positive_regulation MMP9 TNF 25470819 3032067 Positive_regulation MMP9 TNF 9743290 447882 Positive_regulation MMP9 TNF 9743290 447883 Positive_regulation MMP9 TNF 9743290 447884 Positive_regulation MMP9 TNF 9743290 447885 Positive_regulation MMP9 TNF 9743290 447891 Positive_regulation MMP9 TNF PMC2557557 450102 Positive_regulation MMP9 TSPAN1 23840773 2817356 Positive_regulation MMP9 VSNL1 22479362 2614941 Positive_regulation MMP9 WNT7A 24479426 131537 Positive_regulation MN1 MSX1 23316168 960809 Positive_regulation MNAT1 CAPN8 20200223 1774779 Positive_regulation MNAT1 CAPN8 20200223 1774793 Positive_regulation MNAT1 CAPN8 20553580 228797 Positive_regulation MNAT1 CAPN8 21378178 718206 Positive_regulation MNAT1 CAPN8 23241453 3188450 Positive_regulation MNAT1 CAPN8 23688022 483347 Positive_regulation MNAT1 TNF 24586980 2928580 Positive_regulation MOAP1 EPHB2 22951718 1631184 Positive_regulation MOAP1 TNF 24707477 188297 Positive_regulation MOAP1 TNFSF10 22745908 1831367 Positive_regulation MOCOS TNF 17242164 1544202 Positive_regulation MOG MMP7 19267908 385418 Positive_regulation MOK CTGF 18401458 831381 Positive_regulation MOK EPHB2 23358382 1149034 Positive_regulation MOK EPHB2 24465790 2911774 Positive_regulation MOK ITGB2 19426472 525468 Positive_regulation MOK S100B 19292913 1695968 Positive_regulation MOK S100B 20672003 512956 Positive_regulation MOK S100B 20672003 512963 Positive_regulation MOK S100B 20827311 512999 Positive_regulation MOK S100B 20827421 513008 Positive_regulation MOK S100B 20827421 513027 Positive_regulation MOK S100B 20827421 513033 Positive_regulation MOK S100B 21364670 550257 Positive_regulation MOK S100B 21614209 1090918 Positive_regulation MOK S100B 22227007 2008244 Positive_regulation MOK S100B 22276098 2589839 Positive_regulation MOK S100B 22276098 2589840 Positive_regulation MOK S100B 22276098 2589915 Positive_regulation MOK S100B 22276098 2589916 Positive_regulation MOK S100B 22276098 2589947 Positive_regulation MOK S100B 22276098 2589959 Positive_regulation MOK S100B 22474421 832802 Positive_regulation MOK S100B 22779027 1052998 Positive_regulation MOK S100B 23785412 2805750 Positive_regulation MOK S100B 24586862 2927344 Positive_regulation MOK S100B 25265561 3011255 Positive_regulation MOK S100B PMC4070603 3205867 Positive_regulation MOK TNF 19118493 651036 Positive_regulation MOK TNF 19735566 116686 Positive_regulation MOK TNF 20716934 2222697 Positive_regulation MOK TNF 21151899 2485273 Positive_regulation MOK TNF 21970746 354738 Positive_regulation MOK TNF 23894457 2824798 Positive_regulation MOK TNF 24843476 1493334 Positive_regulation MOK TNF 24843553 1493984 Positive_regulation MOK TNF 25025559 1162054 Positive_regulation MOS ITGB2 19175917 352568 Positive_regulation MOS TNF 22110382 1058493 Positive_regulation MPO MIP 21906393 1229627 Positive_regulation MPO TNF 22889165 1664762 Positive_regulation MPO TNF 9927230 1764335 Positive_regulation MPO TNF 9927230 1764336 Positive_regulation MPST TNF 24327924 1831674 Positive_regulation MPZ CAPN8 21318163 2232211 Positive_regulation MPZ CCND1 17407548 1846334 Positive_regulation MPZ TNF 22723850 2654879 Positive_regulation MRC1 EPHB2 23734186 2799533 Positive_regulation MRC2 PLAU 12952933 1296549 Positive_regulation MRE11A EPHB2 23758320 151629 Positive_regulation MRE11A PECAM1 10725328 1256535 Positive_regulation MRE11A PECAM1 10725328 1256568 Positive_regulation MRE11A TNF 16043520 1536943 Positive_regulation MRXS5 SLCO2A1 25126080 965771 Positive_regulation MRXS5 TNF 14613529 3095436 Positive_regulation MS NT5E 18553155 3089931 Positive_regulation MS TNF 22690145 1729487 Positive_regulation MS4A2 RNASE1 23086298 1931754 Positive_regulation MS4A2 RNASE7 23086298 1931762 Positive_regulation MSC IL1B 25562599 3037230 Positive_regulation MSC IL1B 25562599 3037231 Positive_regulation MSC MMP28 23236386 2726071 Positive_regulation MSC MMP7 23236386 2726086 Positive_regulation MSC NES 24572070 3169853 Positive_regulation MSC TNF 20819172 2010908 Positive_regulation MSC TNF 24614867 2933155 Positive_regulation MSC TNF 24842373 1576402 Positive_regulation MSH2 PGC 25506292 3229751 Positive_regulation MSH3 MAP2K6 23320839 482794 Positive_regulation MSH3 PGC 25506292 3229752 Positive_regulation MSH4 PGC 25506292 3229753 Positive_regulation MSH5 PGC 25506292 3229754 Positive_regulation MSH6 PGC 22548174 1155568 Positive_regulation MSH6 PGC 25506292 3229755 Positive_regulation MSI1 EPHB2 20727204 1858211 Positive_regulation MSI1 RNASE1 18490513 1352345 Positive_regulation MSK10 EPHB2 19052640 2401862 Positive_regulation MSK10 EPHB2 21887361 2549516 Positive_regulation MSK10 EPHB2 22761932 2659248 Positive_regulation MSK10 EPHB2 25254549 2364756 Positive_regulation MSK10 TNF 24705157 985091 Positive_regulation MSK32 EPHB2 19052640 2401863 Positive_regulation MSK32 EPHB2 21887361 2549530 Positive_regulation MSK32 EPHB2 22761932 2659249 Positive_regulation MSK32 EPHB2 25254549 2364757 Positive_regulation MSK32 TNF 24705157 985093 Positive_regulation MSK38 EPHB2 19052640 2401864 Positive_regulation MSK38 EPHB2 21887361 2549544 Positive_regulation MSK38 EPHB2 22761932 2659250 Positive_regulation MSK38 EPHB2 25254549 2364758 Positive_regulation MSK38 TNF 24705157 985095 Positive_regulation MSK9 EPHB2 19052640 2401865 Positive_regulation MSK9 EPHB2 21887361 2549558 Positive_regulation MSK9 EPHB2 22761932 2659251 Positive_regulation MSK9 EPHB2 25254549 2364759 Positive_regulation MSK9 TNF 24705157 985097 Positive_regulation MSLN MMP7 23694968 3135772 Positive_regulation MSLN MMP7 23694968 3135773 Positive_regulation MSLN MMP7 23694968 3135999 Positive_regulation MSLN MMP7 23694968 3136009 Positive_regulation MSLN MUC16 24988079 2986117 Positive_regulation MSLN TNF 21880146 1863110 Positive_regulation MSN EPHB2 25406076 3028323 Positive_regulation MSN EPHB2 25406076 3028324 Positive_regulation MSN TSPAN1 21961047 2557518 Positive_regulation MSR1 TNF 25250731 3009906 Positive_regulation MST1 DAPK1 25202403 2169684 Positive_regulation MST1 HBEGF 25186587 1768396 Positive_regulation MST1 STK39 15363108 248494 Positive_regulation MST1R STK39 15363108 248510 Positive_regulation MSTN EPHB2 20419100 2446952 Positive_regulation MSTN EPHB2 20419100 2446953 Positive_regulation MSTN EPHB2 20419100 2446969 Positive_regulation MSTN EPHB2 20419100 2446984 Positive_regulation MSTN EPHB2 20419100 2446985 Positive_regulation MSTN TNF 22477519 1238925 Positive_regulation MSTN TNF 23577254 1155656 Positive_regulation MSTN TNF 24093947 350188 Positive_regulation MSX1 AP2B1 22547091 602867 Positive_regulation MSX1 AP2M1 22547091 602868 Positive_regulation MSX1 AP2S1 22547091 602869 Positive_regulation MSX1 BMP1 12095419 297939 Positive_regulation MSX1 BMP1 16968133 2261886 Positive_regulation MSX1 BMP1 17068080 2023291 Positive_regulation MSX1 BMP1 18844994 301891 Positive_regulation MSX1 BMP1 19913215 96635 Positive_regulation MSX1 BMP1 21383851 2505380 Positive_regulation MSX1 BMP1 22140629 3086089 Positive_regulation MSX1 BMP1 23382810 2746323 Positive_regulation MSX1 BMP1 24550838 963957 Positive_regulation MSX1 BMP1 25058015 2360743 Positive_regulation MSX1 BMP10 12095419 297947 Positive_regulation MSX1 BMP10 16968133 2261894 Positive_regulation MSX1 BMP10 17068080 2023299 Positive_regulation MSX1 BMP10 18844994 301899 Positive_regulation MSX1 BMP10 19913215 96643 Positive_regulation MSX1 BMP10 21383851 2505388 Positive_regulation MSX1 BMP10 22140629 3086097 Positive_regulation MSX1 BMP10 23382810 2746331 Positive_regulation MSX1 BMP10 24550838 963972 Positive_regulation MSX1 BMP10 25058015 2360751 Positive_regulation MSX1 BMP15 12095419 297940 Positive_regulation MSX1 BMP15 16968133 2261887 Positive_regulation MSX1 BMP15 17068080 2023292 Positive_regulation MSX1 BMP15 18844994 301892 Positive_regulation MSX1 BMP15 19913215 96636 Positive_regulation MSX1 BMP15 21383851 2505381 Positive_regulation MSX1 BMP15 22140629 3086090 Positive_regulation MSX1 BMP15 23382810 2746324 Positive_regulation MSX1 BMP15 24550838 963958 Positive_regulation MSX1 BMP15 25058015 2360744 Positive_regulation MSX1 BMP2 12095419 297941 Positive_regulation MSX1 BMP2 16968133 2261888 Positive_regulation MSX1 BMP2 17068080 2023293 Positive_regulation MSX1 BMP2 18844994 301893 Positive_regulation MSX1 BMP2 19424481 671524 Positive_regulation MSX1 BMP2 19913215 96637 Positive_regulation MSX1 BMP2 21383851 2505382 Positive_regulation MSX1 BMP2 22140629 3086091 Positive_regulation MSX1 BMP2 23382810 2746325 Positive_regulation MSX1 BMP2 24550838 963959 Positive_regulation MSX1 BMP2 24799899 1674616 Positive_regulation MSX1 BMP2 25058015 2360745 Positive_regulation MSX1 BMP3 12095419 297942 Positive_regulation MSX1 BMP3 16968133 2261889 Positive_regulation MSX1 BMP3 17068080 2023294 Positive_regulation MSX1 BMP3 18844994 301894 Positive_regulation MSX1 BMP3 19913215 96638 Positive_regulation MSX1 BMP3 21383851 2505383 Positive_regulation MSX1 BMP3 22140629 3086092 Positive_regulation MSX1 BMP3 23382810 2746326 Positive_regulation MSX1 BMP3 24550838 963960 Positive_regulation MSX1 BMP3 25058015 2360746 Positive_regulation MSX1 BMP4 12095419 297943 Positive_regulation MSX1 BMP4 16157866 2017601 Positive_regulation MSX1 BMP4 16968133 2261890 Positive_regulation MSX1 BMP4 17068080 2023295 Positive_regulation MSX1 BMP4 17274816 2220725 Positive_regulation MSX1 BMP4 18404215 2305202 Positive_regulation MSX1 BMP4 18844994 301895 Positive_regulation MSX1 BMP4 19266065 1055495 Positive_regulation MSX1 BMP4 19913215 96639 Positive_regulation MSX1 BMP4 20506112 3170600 Positive_regulation MSX1 BMP4 21383851 2505384 Positive_regulation MSX1 BMP4 22140629 3086093 Positive_regulation MSX1 BMP4 22629441 2646535 Positive_regulation MSX1 BMP4 23382810 2746327 Positive_regulation MSX1 BMP4 23531410 399205 Positive_regulation MSX1 BMP4 24451143 1123348 Positive_regulation MSX1 BMP4 24550718 2299772 Positive_regulation MSX1 BMP4 24550718 2299773 Positive_regulation MSX1 BMP4 24550718 2299774 Positive_regulation MSX1 BMP4 24550718 2299775 Positive_regulation MSX1 BMP4 24550838 963961 Positive_regulation MSX1 BMP4 24883034 806163 Positive_regulation MSX1 BMP4 25058015 2360747 Positive_regulation MSX1 BMP5 12095419 297944 Positive_regulation MSX1 BMP5 16968133 2261891 Positive_regulation MSX1 BMP5 17068080 2023296 Positive_regulation MSX1 BMP5 18844994 301896 Positive_regulation MSX1 BMP5 19913215 96640 Positive_regulation MSX1 BMP5 21383851 2505385 Positive_regulation MSX1 BMP5 22140629 3086094 Positive_regulation MSX1 BMP5 23382810 2746328 Positive_regulation MSX1 BMP5 24550838 963962 Positive_regulation MSX1 BMP5 25058015 2360748 Positive_regulation MSX1 BMP6 12095419 297945 Positive_regulation MSX1 BMP6 16968133 2261892 Positive_regulation MSX1 BMP6 17068080 2023297 Positive_regulation MSX1 BMP6 18844994 301897 Positive_regulation MSX1 BMP6 19913215 96641 Positive_regulation MSX1 BMP6 21383851 2505386 Positive_regulation MSX1 BMP6 22140629 3086095 Positive_regulation MSX1 BMP6 23382810 2746329 Positive_regulation MSX1 BMP6 24550838 963963 Positive_regulation MSX1 BMP6 25058015 2360749 Positive_regulation MSX1 BMP7 12095419 297946 Positive_regulation MSX1 BMP7 16968133 2261893 Positive_regulation MSX1 BMP7 17068080 2023298 Positive_regulation MSX1 BMP7 18844994 301898 Positive_regulation MSX1 BMP7 19913215 96642 Positive_regulation MSX1 BMP7 21383851 2505387 Positive_regulation MSX1 BMP7 22140629 3086096 Positive_regulation MSX1 BMP7 23382810 2746330 Positive_regulation MSX1 BMP7 24550838 963964 Positive_regulation MSX1 BMP7 25058015 2360750 Positive_regulation MSX1 BMPR1A 23316168 960761 Positive_regulation MSX1 CDH1 21433221 3171301 Positive_regulation MSX1 CDH10 21433221 3171302 Positive_regulation MSX1 CDH11 21433221 3171303 Positive_regulation MSX1 CDH12 21433221 3171304 Positive_regulation MSX1 CDH13 21433221 3171305 Positive_regulation MSX1 CDH15 21433221 3171306 Positive_regulation MSX1 CDH16 21433221 3171307 Positive_regulation MSX1 CDH17 21433221 3171308 Positive_regulation MSX1 CDH18 21433221 3171309 Positive_regulation MSX1 CDH19 21433221 3171310 Positive_regulation MSX1 CDH2 21433221 3171311 Positive_regulation MSX1 CDH20 21433221 3171312 Positive_regulation MSX1 CDH22 21433221 3171297 Positive_regulation MSX1 CDH23 21433221 3171298 Positive_regulation MSX1 CDH24 21433221 3171299 Positive_regulation MSX1 CDH26 21433221 3171300 Positive_regulation MSX1 CDH3 21433221 3171313 Positive_regulation MSX1 CDH4 21433221 3171314 Positive_regulation MSX1 CDH5 21433221 3171315 Positive_regulation MSX1 CDH6 21433221 3171316 Positive_regulation MSX1 CDH7 21433221 3171317 Positive_regulation MSX1 CDH8 21433221 3171318 Positive_regulation MSX1 CDH9 21433221 3171319 Positive_regulation MSX1 DLX2 16157866 2017596 Positive_regulation MSX1 DLX2 24799899 1674617 Positive_regulation MSX1 EDN1 22547091 602864 Positive_regulation MSX1 EDN2 22547091 602865 Positive_regulation MSX1 EDN3 22547091 602866 Positive_regulation MSX1 EHMT2 22629437 2646487 Positive_regulation MSX1 EHMT2 22629437 2646488 Positive_regulation MSX1 FGF1 17068080 2023300 Positive_regulation MSX1 FGF1 19913215 96644 Positive_regulation MSX1 FGF1 24550838 963973 Positive_regulation MSX1 FGF10 17068080 2023301 Positive_regulation MSX1 FGF10 19913215 96645 Positive_regulation MSX1 FGF10 24550838 963974 Positive_regulation MSX1 FGF11 17068080 2023302 Positive_regulation MSX1 FGF11 19913215 96646 Positive_regulation MSX1 FGF11 24550838 963975 Positive_regulation MSX1 FGF12 17068080 2023303 Positive_regulation MSX1 FGF12 19913215 96647 Positive_regulation MSX1 FGF12 24550838 963976 Positive_regulation MSX1 FGF13 17068080 2023304 Positive_regulation MSX1 FGF13 19913215 96648 Positive_regulation MSX1 FGF13 24550838 963977 Positive_regulation MSX1 FGF14 17068080 2023305 Positive_regulation MSX1 FGF14 19913215 96649 Positive_regulation MSX1 FGF14 24550838 963978 Positive_regulation MSX1 FGF16 17068080 2023306 Positive_regulation MSX1 FGF16 19913215 96650 Positive_regulation MSX1 FGF16 24550838 963979 Positive_regulation MSX1 FGF17 17068080 2023307 Positive_regulation MSX1 FGF17 19913215 96651 Positive_regulation MSX1 FGF17 24550838 963980 Positive_regulation MSX1 FGF18 17068080 2023308 Positive_regulation MSX1 FGF18 19913215 96652 Positive_regulation MSX1 FGF18 24550838 963981 Positive_regulation MSX1 FGF19 17068080 2023309 Positive_regulation MSX1 FGF19 19913215 96653 Positive_regulation MSX1 FGF19 24550838 963982 Positive_regulation MSX1 FGF2 17068080 2023310 Positive_regulation MSX1 FGF2 19913215 96654 Positive_regulation MSX1 FGF2 24550838 963983 Positive_regulation MSX1 FGF20 17068080 2023311 Positive_regulation MSX1 FGF20 19913215 96655 Positive_regulation MSX1 FGF20 24550838 963984 Positive_regulation MSX1 FGF21 17068080 2023312 Positive_regulation MSX1 FGF21 19913215 96656 Positive_regulation MSX1 FGF21 24550838 963985 Positive_regulation MSX1 FGF22 17068080 2023313 Positive_regulation MSX1 FGF22 19913215 96657 Positive_regulation MSX1 FGF22 24550838 963986 Positive_regulation MSX1 FGF23 17068080 2023314 Positive_regulation MSX1 FGF23 19913215 96658 Positive_regulation MSX1 FGF23 24550838 963987 Positive_regulation MSX1 FGF3 17068080 2023315 Positive_regulation MSX1 FGF3 19913215 96659 Positive_regulation MSX1 FGF3 24550838 963988 Positive_regulation MSX1 FGF4 17068080 2023316 Positive_regulation MSX1 FGF4 19913215 96660 Positive_regulation MSX1 FGF4 24550838 963989 Positive_regulation MSX1 FGF5 17068080 2023317 Positive_regulation MSX1 FGF5 19913215 96661 Positive_regulation MSX1 FGF5 24550838 963990 Positive_regulation MSX1 FGF6 17068080 2023318 Positive_regulation MSX1 FGF6 19913215 96662 Positive_regulation MSX1 FGF6 24550838 963991 Positive_regulation MSX1 FGF7 17068080 2023319 Positive_regulation MSX1 FGF7 19913215 96663 Positive_regulation MSX1 FGF7 24550838 963992 Positive_regulation MSX1 FGF8 16157866 2017595 Positive_regulation MSX1 FGF8 17068080 2023320 Positive_regulation MSX1 FGF8 19913215 96664 Positive_regulation MSX1 FGF8 24550838 963993 Positive_regulation MSX1 FGF8 24883034 806164 Positive_regulation MSX1 FGF9 17068080 2023321 Positive_regulation MSX1 FGF9 19913215 96665 Positive_regulation MSX1 FGF9 23176204 533675 Positive_regulation MSX1 FGF9 23176204 533678 Positive_regulation MSX1 FGF9 24550838 963994 Positive_regulation MSX1 GYS1 21433221 3171442 Positive_regulation MSX1 GYS2 21433221 3171443 Positive_regulation MSX1 HOXB1 21433221 3171320 Positive_regulation MSX1 HOXB1 21433221 3171393 Positive_regulation MSX1 HOXB1 21433221 3171426 Positive_regulation MSX1 HOXB1 21433221 3171427 Positive_regulation MSX1 HOXB1 21433221 3171444 Positive_regulation MSX1 HOXB1 25136598 197274 Positive_regulation MSX1 LIF 17462098 3096431 Positive_regulation MSX1 LMX1A 18826576 1832838 Positive_regulation MSX1 LMX1A 22276170 2590301 Positive_regulation MSX1 MN1 23316168 960810 Positive_regulation MSX1 MSX2 21433221 3171321 Positive_regulation MSX1 NEUROG2 22276170 2590297 Positive_regulation MSX1 OTX2 22276170 2590302 Positive_regulation MSX1 PAX9 19591819 698123 Positive_regulation MSX1 PIAS1 23620817 2783520 Positive_regulation MSX1 SHH 20021670 236421 Positive_regulation MSX1 SNAI2 21433221 3171296 Positive_regulation MSX1 TTR 24550718 2300502 Positive_regulation MSX1 WNT1 23055979 959167 Positive_regulation MSX1 WNT1 23055979 959168 Positive_regulation MSX1 WNT1 23055979 959169 Positive_regulation MSX1 WNT1 23055979 959217 Positive_regulation MSX1 WNT1 24550838 963965 Positive_regulation MSX1 WNT11 23055979 959170 Positive_regulation MSX1 WNT11 23055979 959171 Positive_regulation MSX1 WNT11 23055979 959172 Positive_regulation MSX1 WNT11 23055979 959218 Positive_regulation MSX1 WNT11 24550838 963966 Positive_regulation MSX1 WNT16 23055979 959185 Positive_regulation MSX1 WNT16 23055979 959186 Positive_regulation MSX1 WNT16 23055979 959187 Positive_regulation MSX1 WNT16 23055979 959223 Positive_regulation MSX1 WNT16 24550838 963971 Positive_regulation MSX1 WNT2 23055979 959173 Positive_regulation MSX1 WNT2 23055979 959174 Positive_regulation MSX1 WNT2 23055979 959175 Positive_regulation MSX1 WNT2 23055979 959219 Positive_regulation MSX1 WNT2 24550838 963967 Positive_regulation MSX1 WNT3 23055979 959176 Positive_regulation MSX1 WNT3 23055979 959177 Positive_regulation MSX1 WNT3 23055979 959178 Positive_regulation MSX1 WNT3 23055979 959220 Positive_regulation MSX1 WNT3 24550838 963968 Positive_regulation MSX1 WNT3A 23055979 959209 Positive_regulation MSX1 WNT4 23055979 959179 Positive_regulation MSX1 WNT4 23055979 959180 Positive_regulation MSX1 WNT4 23055979 959181 Positive_regulation MSX1 WNT4 23055979 959221 Positive_regulation MSX1 WNT4 24550838 963969 Positive_regulation MSX1 WNT6 23055979 959182 Positive_regulation MSX1 WNT6 23055979 959183 Positive_regulation MSX1 WNT6 23055979 959184 Positive_regulation MSX1 WNT6 23055979 959222 Positive_regulation MSX1 WNT6 24550838 963970 Positive_regulation MSX2 CCND1 22697792 471625 Positive_regulation MSX2 EPHB2 20682066 465995 Positive_regulation MSX2 MSX1 21433221 3171347 Positive_regulation MT-CO2 CA12 11270 1607183 Positive_regulation MT-CO2 CA12 20420710 328849 Positive_regulation MT-CO2 CA12 21143847 379598 Positive_regulation MT-CO2 CA12 23869188 1084704 Positive_regulation MT-CO2 CA12 6619 1612379 Positive_regulation MT-CO2 CA12 993774 1613009 Positive_regulation MT-CO2 MUC16 19889237 326894 Positive_regulation MT-CYB TNF 1357073 1528550 Positive_regulation MT-CYB TNF 7836910 1592425 Positive_regulation MT1H CAPN8 22407449 87042 Positive_regulation MT3 TNF 12061424 1738142 Positive_regulation MTA1 TLR7 25117662 2996892 Positive_regulation MTA2 TLR7 25117662 2996902 Positive_regulation MTA3 TLR7 25117662 2996882 Positive_regulation MTDH TNF 18575609 2391619 Positive_regulation MTDH TNF 22768080 2659638 Positive_regulation MTDH TNF 22768080 2659640 Positive_regulation MTDH TNF 24063540 1869738 Positive_regulation MTOR ABCA4 23847761 945765 Positive_regulation MTOR AXIN2 22319467 929513 Positive_regulation MTOR CCND1 18301781 2014145 Positive_regulation MTOR CCND1 21049085 2120725 Positive_regulation MTOR CCND1 22359572 2597713 Positive_regulation MTOR CCND1 23382981 2747445 Positive_regulation MTOR CTGF 25478966 3032188 Positive_regulation MTOR EPHB2 20162032 927767 Positive_regulation MTOR EPHB2 21200439 2489547 Positive_regulation MTOR EPHB2 21283628 2496998 Positive_regulation MTOR EPHB2 21738705 2533421 Positive_regulation MTOR EPHB2 22028687 860492 Positive_regulation MTOR EPHB2 22028687 860562 Positive_regulation MTOR EPHB2 22159814 1140682 Positive_regulation MTOR EPHB2 22880048 2673712 Positive_regulation MTOR EPHB2 23077579 2704796 Positive_regulation MTOR EPHB2 23077579 2704807 Positive_regulation MTOR EPHB2 23077579 2704811 Positive_regulation MTOR EPHB2 23431403 2755370 Positive_regulation MTOR EPHB2 23431403 2755432 Positive_regulation MTOR EPHB2 23431403 2755440 Positive_regulation MTOR EPHB2 23563240 1086798 Positive_regulation MTOR EPHB2 23624914 2152082 Positive_regulation MTOR EPHB2 23624914 2152095 Positive_regulation MTOR EPHB2 23862076 2003147 Positive_regulation MTOR EPHB2 23877835 1901308 Positive_regulation MTOR EPHB2 24155705 897552 Positive_regulation MTOR EPHB2 24245980 1161753 Positive_regulation MTOR EPHB2 24303063 2887910 Positive_regulation MTOR EPHB2 24611062 880268 Positive_regulation MTOR EPHB2 24611062 880295 Positive_regulation MTOR EPHB2 24611062 880363 Positive_regulation MTOR EPHB2 24612393 1692535 Positive_regulation MTOR EPHB2 24710474 618084 Positive_regulation MTOR EPHB2 24710474 618113 Positive_regulation MTOR EPHB2 25364579 478555 Positive_regulation MTOR FBXO32 24237131 665030 Positive_regulation MTOR FOXO1 23875175 945971 Positive_regulation MTOR FOXO1 24228024 694187 Positive_regulation MTOR HBEGF 22984591 2689365 Positive_regulation MTOR HBEGF 22984591 2689368 Positive_regulation MTOR IGFBP1 15350195 369614 Positive_regulation MTOR MAP2K6 21738705 2533427 Positive_regulation MTOR MAP2K6 24041012 746106 Positive_regulation MTOR MAP2K6 24810962 2190403 Positive_regulation MTOR PGC 22351927 1395777 Positive_regulation MTOR RAB31 22523661 1670332 Positive_regulation MTOR STK39 19229373 686320 Positive_regulation MTOR TLR7 24740015 2954087 Positive_regulation MTOR TLR7 25200751 3145526 Positive_regulation MTOR TLR7 PMC3019517 395579 Positive_regulation MTOR TNF 22069489 2569146 Positive_regulation MTOR TNF 22411934 30559 Positive_regulation MTOR TNF 22848663 2669988 Positive_regulation MTOR TNF 23091709 86658 Positive_regulation MTOR TNF 24137160 909293 Positive_regulation MTOR TNF 24312355 2888906 Positive_regulation MTRNR2L4 PGC 19429690 2045847 Positive_regulation MTRR CLU 23805218 2807877 Positive_regulation MTTP FOXO1 20423497 2112647 Positive_regulation MTTP FOXO1 20423497 2112649 Positive_regulation MTTP FOXO1 20423497 2112651 Positive_regulation MTTP TNF 10815618 1737073 Positive_regulation MTTP TNF 10815618 1737074 Positive_regulation MTTP TNF 10815618 1737087 Positive_regulation MTX1 ABCC11 21182469 91918 Positive_regulation MTX1 ABCC11 23316210 883354 Positive_regulation MTX1 SYNM 6945118 443765 Positive_regulation MUC1 ABCG2 24161965 1703495 Positive_regulation MUC1 AGR2 22514630 2619563 Positive_regulation MUC1 AGR2 22945649 2148362 Positive_regulation MUC1 AGR2 22945649 2148363 Positive_regulation MUC1 AGR2 22945649 2148364 Positive_regulation MUC1 AGR2 22945649 2148365 Positive_regulation MUC1 AGR2 22945649 2148366 Positive_regulation MUC1 AGR2 22945649 2148367 Positive_regulation MUC1 AGR2 22945649 2148377 Positive_regulation MUC1 AGR2 22945649 2148397 Positive_regulation MUC1 AGR2 22945649 2148398 Positive_regulation MUC1 AGR2 22945649 2148401 Positive_regulation MUC1 AGR2 22945649 2148402 Positive_regulation MUC1 AGR2 23635006 473269 Positive_regulation MUC1 CTGF 20697347 2133462 Positive_regulation MUC1 EPHB2 12482999 1633232 Positive_regulation MUC1 EPHB2 12482999 1633233 Positive_regulation MUC1 EPHB2 12482999 1633777 Positive_regulation MUC1 EPHB2 16491824 1711329 Positive_regulation MUC1 MAP2K6 12482999 1633241 Positive_regulation MUC1 MAP2K6 12482999 1633785 Positive_regulation MUC1 MAP2K6 22216327 2585616 Positive_regulation MUC1 MMP28 20920189 3111156 Positive_regulation MUC1 MMP7 20920189 3111171 Positive_regulation MUC1 RAB31 22792175 2661053 Positive_regulation MUC1 RAB31 22792175 2661056 Positive_regulation MUC1 RAB31 22792175 2661060 Positive_regulation MUC1 RAB31 22792175 2661062 Positive_regulation MUC1 RAB31 22792175 2661075 Positive_regulation MUC1 RAB31 25261375 2202247 Positive_regulation MUC1 S100A7 23300877 2736922 Positive_regulation MUC1 TNF 12482999 1634129 Positive_regulation MUC1 TNF 17391532 3108200 Positive_regulation MUC1 TNF 19668469 649383 Positive_regulation MUC1 TNF 22242039 634025 Positive_regulation MUC1 TNF 22577246 1749752 Positive_regulation MUC1 TNF 22577246 1749753 Positive_regulation MUC1 TNF 22577246 1749778 Positive_regulation MUC1 TNF 22577246 1749871 Positive_regulation MUC1 TNF 24348668 3204704 Positive_regulation MUC1 TNF 24348668 3204705 Positive_regulation MUC1 TNF 24348668 3204706 Positive_regulation MUC1 TNF 24348668 3204746 Positive_regulation MUC1 TNF 24348668 3204747 Positive_regulation MUC1 TNF 24475103 2914829 Positive_regulation MUC1 TNF 25147434 1761102 Positive_regulation MUC1 TNF 25489420 206838 Positive_regulation MUC1 TNF 25489420 206839 Positive_regulation MUC1 TNF 25489420 206840 Positive_regulation MUC1 TNF 25489420 206878 Positive_regulation MUC1 TNF 25489420 206893 Positive_regulation MUC1 TNF 25489420 206926 Positive_regulation MUC1 TNF 25489420 206942 Positive_regulation MUC1 TNF 9400742 797517 Positive_regulation MUC12 AGR2 22514630 2619564 Positive_regulation MUC12 AGR2 22945649 2148368 Positive_regulation MUC12 AGR2 23635006 473270 Positive_regulation MUC12 EPHB2 12482999 1633258 Positive_regulation MUC12 EPHB2 12482999 1633259 Positive_regulation MUC12 EPHB2 12482999 1633791 Positive_regulation MUC12 EPHB2 16491824 1711330 Positive_regulation MUC12 MAP2K6 12482999 1633267 Positive_regulation MUC12 MAP2K6 12482999 1633799 Positive_regulation MUC12 MMP28 20920189 3111178 Positive_regulation MUC12 MMP7 20920189 3111193 Positive_regulation MUC12 TNF 12482999 1634131 Positive_regulation MUC12 TNF 17391532 3108201 Positive_regulation MUC12 TNF 19668469 649384 Positive_regulation MUC12 TNF 22577246 1749754 Positive_regulation MUC12 TNF 22577246 1749755 Positive_regulation MUC12 TNF 22577246 1749779 Positive_regulation MUC12 TNF 22577246 1749872 Positive_regulation MUC12 TNF 24348668 3204707 Positive_regulation MUC12 TNF 24348668 3204708 Positive_regulation MUC12 TNF 24348668 3204709 Positive_regulation MUC12 TNF 24348668 3204748 Positive_regulation MUC12 TNF 24348668 3204749 Positive_regulation MUC12 TNF 25147434 1761103 Positive_regulation MUC12 TNF 25489420 206841 Positive_regulation MUC12 TNF 25489420 206842 Positive_regulation MUC12 TNF 25489420 206843 Positive_regulation MUC12 TNF 25489420 206879 Positive_regulation MUC12 TNF 25489420 206894 Positive_regulation MUC12 TNF 25489420 206927 Positive_regulation MUC12 TNF 25489420 206943 Positive_regulation MUC12 TNF 9400742 797521 Positive_regulation MUC13 AGR2 22514630 2619565 Positive_regulation MUC13 AGR2 22945649 2148369 Positive_regulation MUC13 AGR2 23635006 473271 Positive_regulation MUC13 EPHB2 12482999 1633284 Positive_regulation MUC13 EPHB2 12482999 1633285 Positive_regulation MUC13 EPHB2 12482999 1633805 Positive_regulation MUC13 EPHB2 16491824 1711331 Positive_regulation MUC13 MAP2K6 12482999 1633293 Positive_regulation MUC13 MAP2K6 12482999 1633813 Positive_regulation MUC13 MMP28 20920189 3111200 Positive_regulation MUC13 MMP7 20920189 3111215 Positive_regulation MUC13 TNF 12482999 1634133 Positive_regulation MUC13 TNF 17391532 3108202 Positive_regulation MUC13 TNF 19668469 649385 Positive_regulation MUC13 TNF 22577246 1749756 Positive_regulation MUC13 TNF 22577246 1749757 Positive_regulation MUC13 TNF 22577246 1749780 Positive_regulation MUC13 TNF 22577246 1749873 Positive_regulation MUC13 TNF 24348668 3204710 Positive_regulation MUC13 TNF 24348668 3204711 Positive_regulation MUC13 TNF 24348668 3204712 Positive_regulation MUC13 TNF 24348668 3204750 Positive_regulation MUC13 TNF 24348668 3204751 Positive_regulation MUC13 TNF 25147434 1761104 Positive_regulation MUC13 TNF 25489420 206844 Positive_regulation MUC13 TNF 25489420 206845 Positive_regulation MUC13 TNF 25489420 206846 Positive_regulation MUC13 TNF 25489420 206880 Positive_regulation MUC13 TNF 25489420 206895 Positive_regulation MUC13 TNF 25489420 206928 Positive_regulation MUC13 TNF 25489420 206944 Positive_regulation MUC13 TNF 9400742 797525 Positive_regulation MUC15 AGR2 22514630 2619557 Positive_regulation MUC15 AGR2 22945649 2148347 Positive_regulation MUC15 AGR2 23635006 473261 Positive_regulation MUC15 EPHB2 12482999 1633045 Positive_regulation MUC15 EPHB2 12482999 1633046 Positive_regulation MUC15 EPHB2 12482999 1633667 Positive_regulation MUC15 EPHB2 16491824 1711323 Positive_regulation MUC15 MAP2K6 12482999 1633054 Positive_regulation MUC15 MAP2K6 12482999 1633675 Positive_regulation MUC15 MMP28 20920189 3111024 Positive_regulation MUC15 MMP7 20920189 3111039 Positive_regulation MUC15 TNF 12482999 1634075 Positive_regulation MUC15 TNF 17391532 3108194 Positive_regulation MUC15 TNF 19668469 649377 Positive_regulation MUC15 TNF 22577246 1749740 Positive_regulation MUC15 TNF 22577246 1749741 Positive_regulation MUC15 TNF 22577246 1749772 Positive_regulation MUC15 TNF 22577246 1749865 Positive_regulation MUC15 TNF 24348668 3204686 Positive_regulation MUC15 TNF 24348668 3204687 Positive_regulation MUC15 TNF 24348668 3204688 Positive_regulation MUC15 TNF 24348668 3204734 Positive_regulation MUC15 TNF 24348668 3204735 Positive_regulation MUC15 TNF 25147434 1761096 Positive_regulation MUC15 TNF 25489420 206820 Positive_regulation MUC15 TNF 25489420 206821 Positive_regulation MUC15 TNF 25489420 206822 Positive_regulation MUC15 TNF 25489420 206866 Positive_regulation MUC15 TNF 25489420 206887 Positive_regulation MUC15 TNF 25489420 206920 Positive_regulation MUC15 TNF 25489420 206936 Positive_regulation MUC15 TNF 9400742 797493 Positive_regulation MUC16 AGR2 22514630 2619558 Positive_regulation MUC16 AGR2 22945649 2148348 Positive_regulation MUC16 AGR2 23635006 473262 Positive_regulation MUC16 AHR 22500183 1156096 Positive_regulation MUC16 AHR 22500183 1156111 Positive_regulation MUC16 AREGB 23675190 1064653 Positive_regulation MUC16 ARSH 11834466 790246 Positive_regulation MUC16 ATOH1 22719768 1143455 Positive_regulation MUC16 ATP8A2 10682684 416364 Positive_regulation MUC16 CA2 11004201 1607070 Positive_regulation MUC16 CA2 21283816 2498321 Positive_regulation MUC16 CA2 21283816 2498394 Positive_regulation MUC16 CCL2 24101903 962402 Positive_regulation MUC16 CD82 19788761 1768099 Positive_regulation MUC16 CDC73 19434244 646196 Positive_regulation MUC16 CDT1 22013477 695902 Positive_regulation MUC16 CDX2 19412438 668999 Positive_regulation MUC16 CLCA1 23073314 807093 Positive_regulation MUC16 CTR9 19434244 646197 Positive_regulation MUC16 DUOX1 23691121 2794587 Positive_regulation MUC16 DUOX1 23691121 2794604 Positive_regulation MUC16 EGF 16491824 1711293 Positive_regulation MUC16 EGF 21326240 436476 Positive_regulation MUC16 EGF 23166555 3204490 Positive_regulation MUC16 EGF 23166555 3204510 Positive_regulation MUC16 EGF 24734099 3204771 Positive_regulation MUC16 EGF 24734099 3204772 Positive_regulation MUC16 EGF 24734099 3204819 Positive_regulation MUC16 EGF PMC3373779 297836 Positive_regulation MUC16 EGFR 11686870 3102973 Positive_regulation MUC16 EGFR 16491824 1711294 Positive_regulation MUC16 EGFR 18039368 3108690 Positive_regulation MUC16 EGFR 22701684 2651884 Positive_regulation MUC16 ELANE 16491824 1710747 Positive_regulation MUC16 ELANE 17352829 3107938 Positive_regulation MUC16 ELANE 21655064 1635438 Positive_regulation MUC16 ELANE 25405776 3028060 Positive_regulation MUC16 EPHB2 12482999 1633071 Positive_regulation MUC16 EPHB2 12482999 1633072 Positive_regulation MUC16 EPHB2 12482999 1633681 Positive_regulation MUC16 EPHB2 16491824 1711324 Positive_regulation MUC16 ERVK-6 11544169 790138 Positive_regulation MUC16 F2RL1 22916223 2680223 Positive_regulation MUC16 F2RL1 22916223 2680251 Positive_regulation MUC16 FGF10 22065934 1913073 Positive_regulation MUC16 FGFR1 24958148 1767225 Positive_regulation MUC16 FGFR2 24958148 1767226 Positive_regulation MUC16 FGFR3 24958148 1767227 Positive_regulation MUC16 FGFR3 8270909 1612613 Positive_regulation MUC16 FGFR4 24958148 1767228 Positive_regulation MUC16 FIGF 24502459 3102410 Positive_regulation MUC16 FIGF 24502459 3102411 Positive_regulation MUC16 GNAS 23403822 440224 Positive_regulation MUC16 GNAS 24498386 2919285 Positive_regulation MUC16 GNAS 24498386 2919286 Positive_regulation MUC16 GNAS 24498386 2919376 Positive_regulation MUC16 IFFO1 22163280 2578049 Positive_regulation MUC16 IL10 21331365 632327 Positive_regulation MUC16 IL10 21331365 632353 Positive_regulation MUC16 IL12A 22606349 2643391 Positive_regulation MUC16 IL12B 22606349 2643392 Positive_regulation MUC16 IL13 11686870 3102988 Positive_regulation MUC16 IL13 18794337 1552013 Positive_regulation MUC16 IL13 21655064 1635389 Positive_regulation MUC16 IL13 21655064 1635390 Positive_regulation MUC16 IL13 21946417 1955836 Positive_regulation MUC16 IL13 22754714 35738 Positive_regulation MUC16 IL13 23283176 3225436 Positive_regulation MUC16 IL13 24065956 879250 Positive_regulation MUC16 IL13 24416647 1708172 Positive_regulation MUC16 IL13 24453426 1757037 Positive_regulation MUC16 IL13 24914235 1419705 Positive_regulation MUC16 IL13 25147434 1761116 Positive_regulation MUC16 IL13 25398130 3027521 Positive_regulation MUC16 IL17A 20565710 3110565 Positive_regulation MUC16 IL17A 21695271 2530137 Positive_regulation MUC16 IL17A 23342289 82656 Positive_regulation MUC16 IL17A 23505509 2766363 Positive_regulation MUC16 IL17A 24453426 1756993 Positive_regulation MUC16 IL17A 24489575 639585 Positive_regulation MUC16 IL17A 25141009 3000429 Positive_regulation MUC16 IL17A 25147434 1761117 Positive_regulation MUC16 IL17A 25206355 913996 Positive_regulation MUC16 IL17A 25398130 3027522 Positive_regulation MUC16 IL1A 12482999 1633073 Positive_regulation MUC16 IL1A 12482999 1633074 Positive_regulation MUC16 IL1A 12482999 1633682 Positive_regulation MUC16 IL1A 12482999 1633683 Positive_regulation MUC16 IL1A 12482999 1633980 Positive_regulation MUC16 IL1A 12482999 1634078 Positive_regulation MUC16 IL1A 20962773 1917944 Positive_regulation MUC16 IL1A 22294049 1918624 Positive_regulation MUC16 IL22 24130494 3064524 Positive_regulation MUC16 IL33 21695271 2530136 Positive_regulation MUC16 IL4 15203548 1739555 Positive_regulation MUC16 IL4 20725596 3225147 Positive_regulation MUC16 IL4 20962773 1917945 Positive_regulation MUC16 IL4 21695271 2530138 Positive_regulation MUC16 IL6 17352829 3107908 Positive_regulation MUC16 IL6 20565710 3110566 Positive_regulation MUC16 IL6 21331365 632354 Positive_regulation MUC16 IL6 21695271 2530139 Positive_regulation MUC16 IL6 24453426 1756994 Positive_regulation MUC16 IL6 24453426 1757052 Positive_regulation MUC16 IL6 25147434 1761118 Positive_regulation MUC16 IL8 19434244 646173 Positive_regulation MUC16 IL8 20962773 1917946 Positive_regulation MUC16 IL9 20053303 118081 Positive_regulation MUC16 IL9 20525149 34505 Positive_regulation MUC16 LEO1 19434244 646200 Positive_regulation MUC16 LEP 21124310 1918098 Positive_regulation MUC16 LEP 24288549 1156450 Positive_regulation MUC16 LEP 24714276 88502 Positive_regulation MUC16 MAP2K1 12482999 1633075 Positive_regulation MUC16 MAP2K1 12482999 1633684 Positive_regulation MUC16 MAP2K2 12482999 1633076 Positive_regulation MUC16 MAP2K2 12482999 1633685 Positive_regulation MUC16 MAP2K3 12482999 1633077 Positive_regulation MUC16 MAP2K3 12482999 1633686 Positive_regulation MUC16 MAP2K4 12482999 1633078 Positive_regulation MUC16 MAP2K4 12482999 1633687 Positive_regulation MUC16 MAP2K5 12482999 1633079 Positive_regulation MUC16 MAP2K5 12482999 1633688 Positive_regulation MUC16 MAP2K6 12482999 1633080 Positive_regulation MUC16 MAP2K6 12482999 1633689 Positive_regulation MUC16 MAP2K7 12482999 1633081 Positive_regulation MUC16 MAP2K7 12482999 1633690 Positive_regulation MUC16 MAPK1 12482999 1633082 Positive_regulation MUC16 MAPK1 16491824 1710748 Positive_regulation MUC16 MAPK1 17029558 2302898 Positive_regulation MUC16 MAPK1 24498386 2919377 Positive_regulation MUC16 MAPK10 12482999 1633083 Positive_regulation MUC16 MAPK10 16491824 1710749 Positive_regulation MUC16 MAPK10 17029558 2302899 Positive_regulation MUC16 MAPK10 24498386 2919378 Positive_regulation MUC16 MAPK11 12482999 1633084 Positive_regulation MUC16 MAPK11 16491824 1710750 Positive_regulation MUC16 MAPK11 17029558 2302900 Positive_regulation MUC16 MAPK11 24498386 2919379 Positive_regulation MUC16 MAPK12 12482999 1633085 Positive_regulation MUC16 MAPK12 16491824 1710751 Positive_regulation MUC16 MAPK12 17029558 2302901 Positive_regulation MUC16 MAPK12 24498386 2919380 Positive_regulation MUC16 MAPK13 12482999 1633086 Positive_regulation MUC16 MAPK13 16491824 1710752 Positive_regulation MUC16 MAPK13 17029558 2302902 Positive_regulation MUC16 MAPK13 24498386 2919381 Positive_regulation MUC16 MAPK14 12482999 1633087 Positive_regulation MUC16 MAPK14 16491824 1710753 Positive_regulation MUC16 MAPK14 17029558 2302903 Positive_regulation MUC16 MAPK14 24498386 2919382 Positive_regulation MUC16 MAPK15 12482999 1633070 Positive_regulation MUC16 MAPK15 16491824 1710746 Positive_regulation MUC16 MAPK15 17029558 2302897 Positive_regulation MUC16 MAPK15 24498386 2919375 Positive_regulation MUC16 MAPK3 12482999 1633088 Positive_regulation MUC16 MAPK3 16491824 1710754 Positive_regulation MUC16 MAPK3 16491824 1711209 Positive_regulation MUC16 MAPK3 17029558 2302904 Positive_regulation MUC16 MAPK3 24498386 2919383 Positive_regulation MUC16 MAPK4 12482999 1633089 Positive_regulation MUC16 MAPK4 16491824 1710755 Positive_regulation MUC16 MAPK4 17029558 2302905 Positive_regulation MUC16 MAPK4 24498386 2919384 Positive_regulation MUC16 MAPK6 12482999 1633090 Positive_regulation MUC16 MAPK6 16491824 1710756 Positive_regulation MUC16 MAPK6 17029558 2302906 Positive_regulation MUC16 MAPK6 24498386 2919385 Positive_regulation MUC16 MAPK7 12482999 1633091 Positive_regulation MUC16 MAPK7 16491824 1710757 Positive_regulation MUC16 MAPK7 17029558 2302907 Positive_regulation MUC16 MAPK7 24498386 2919386 Positive_regulation MUC16 MAPK8 12482999 1633092 Positive_regulation MUC16 MAPK8 16491824 1710758 Positive_regulation MUC16 MAPK8 17029558 2302908 Positive_regulation MUC16 MAPK8 24498386 2919387 Positive_regulation MUC16 MAPK9 12482999 1633093 Positive_regulation MUC16 MAPK9 16491824 1710759 Positive_regulation MUC16 MAPK9 17029558 2302909 Positive_regulation MUC16 MAPK9 24498386 2919388 Positive_regulation MUC16 MBP 19788761 1768100 Positive_regulation MUC16 ME2 24957098 3142725 Positive_regulation MUC16 MECOM 17029558 2303334 Positive_regulation MUC16 MMP1 20920189 3111047 Positive_regulation MUC16 MMP10 20920189 3111048 Positive_regulation MUC16 MMP11 20920189 3111049 Positive_regulation MUC16 MMP12 20920189 3111050 Positive_regulation MUC16 MMP13 20920189 3111051 Positive_regulation MUC16 MMP14 20920189 3111052 Positive_regulation MUC16 MMP15 20920189 3111053 Positive_regulation MUC16 MMP16 20920189 3111054 Positive_regulation MUC16 MMP17 20920189 3111055 Positive_regulation MUC16 MMP19 20920189 3111056 Positive_regulation MUC16 MMP2 20920189 3111057 Positive_regulation MUC16 MMP20 20920189 3111058 Positive_regulation MUC16 MMP21 20920189 3111045 Positive_regulation MUC16 MMP24 20920189 3111059 Positive_regulation MUC16 MMP25 20920189 3111042 Positive_regulation MUC16 MMP26 20920189 3111043 Positive_regulation MUC16 MMP27 20920189 3111044 Positive_regulation MUC16 MMP28 20920189 3111046 Positive_regulation MUC16 MMP3 20920189 3111060 Positive_regulation MUC16 MMP7 20920189 3111061 Positive_regulation MUC16 MMP7 23694968 3135763 Positive_regulation MUC16 MMP7 23694968 3135764 Positive_regulation MUC16 MMP7 23694968 3136003 Positive_regulation MUC16 MMP8 20920189 3111062 Positive_regulation MUC16 MMP9 20920189 3111063 Positive_regulation MUC16 MMP9 24353864 646718 Positive_regulation MUC16 MSLN 23694968 3135809 Positive_regulation MUC16 MT-CO2 24886434 273569 Positive_regulation MUC16 MUC5AC 16491824 1710760 Positive_regulation MUC16 MUC5AC 17029558 2302910 Positive_regulation MUC16 MUC5AC 17029558 2303335 Positive_regulation MUC16 NAMPT 24885580 1233673 Positive_regulation MUC16 NAMPT 24885580 1233784 Positive_regulation MUC16 NAMPT 24885580 1233988 Positive_regulation MUC16 NAMPT 24885580 1234035 Positive_regulation MUC16 NELFCD 24386378 2903795 Positive_regulation MUC16 NGF 21179428 1912491 Positive_regulation MUC16 NGF 23836957 649623 Positive_regulation MUC16 NOS1 9400742 797498 Positive_regulation MUC16 NOS2 9400742 797499 Positive_regulation MUC16 NOS3 9400742 797500 Positive_regulation MUC16 NPS 21283816 2498322 Positive_regulation MUC16 NPS 21283816 2498323 Positive_regulation MUC16 NPS 21283816 2498395 Positive_regulation MUC16 NPS 21283816 2498439 Positive_regulation MUC16 NPS 21283816 2498440 Positive_regulation MUC16 NPS 21283816 2498482 Positive_regulation MUC16 NPS 22065934 1913095 Positive_regulation MUC16 NR4A3 17391532 3108178 Positive_regulation MUC16 NTS 24587990 187319 Positive_regulation MUC16 PAF1 19434244 646198 Positive_regulation MUC16 PAK1 22768318 2660596 Positive_regulation MUC16 PAK2 22768318 2660597 Positive_regulation MUC16 PAK3 22768318 2660598 Positive_regulation MUC16 PAK4 22768318 2660594 Positive_regulation MUC16 PAK6 22768318 2660595 Positive_regulation MUC16 PAK7 22768318 2660593 Positive_regulation MUC16 PDLIM7 24662828 2154886 Positive_regulation MUC16 PI3 12482999 1633691 Positive_regulation MUC16 PIK3CA 12482999 1633094 Positive_regulation MUC16 PIK3CA 12482999 1633692 Positive_regulation MUC16 PIK3CA 12482999 1633909 Positive_regulation MUC16 PIK3CA 12482999 1633981 Positive_regulation MUC16 PIK3R1 12482999 1633095 Positive_regulation MUC16 PIK3R1 12482999 1633693 Positive_regulation MUC16 PIK3R1 12482999 1633910 Positive_regulation MUC16 PIK3R1 12482999 1633982 Positive_regulation MUC16 PLEC 23915402 3113812 Positive_regulation MUC16 PLEC 23915402 3113813 Positive_regulation MUC16 PLEC 23915402 3113856 Positive_regulation MUC16 PRKACB 23403822 440121 Positive_regulation MUC16 PRKACB 24757369 1716344 Positive_regulation MUC16 PRKACG 23403822 440122 Positive_regulation MUC16 PRKACG 24757369 1716345 Positive_regulation MUC16 PRKAR1A 23403822 440123 Positive_regulation MUC16 PRKAR1A 24757369 1716346 Positive_regulation MUC16 PRKAR1B 23403822 440124 Positive_regulation MUC16 PRKAR1B 24757369 1716347 Positive_regulation MUC16 PRKAR2A 23403822 440125 Positive_regulation MUC16 PRKAR2A 24757369 1716348 Positive_regulation MUC16 PRKAR2B 23403822 440126 Positive_regulation MUC16 PRKAR2B 24757369 1716349 Positive_regulation MUC16 QRICH1 22844397 2667999 Positive_regulation MUC16 QRICH2 22844397 2668000 Positive_regulation MUC16 RABEPK 22606349 2643390 Positive_regulation MUC16 SAA1 24694941 1703527 Positive_regulation MUC16 SAA1 25136510 84976 Positive_regulation MUC16 SETD2 23119050 2712646 Positive_regulation MUC16 SETD2 23462909 1919781 Positive_regulation MUC16 SLC26A4 25141009 3000445 Positive_regulation MUC16 SNAP23 24065956 879265 Positive_regulation MUC16 SPDEF 21203431 2490197 Positive_regulation MUC16 SRC 12482999 1633680 Positive_regulation MUC16 STAT6 21203431 2490196 Positive_regulation MUC16 STAT6 24416647 1708215 Positive_regulation MUC16 STX3 22694344 150753 Positive_regulation MUC16 SYT1 25489420 206904 Positive_regulation MUC16 TLR2 19656404 353025 Positive_regulation MUC16 TLR2 20885960 2475769 Positive_regulation MUC16 TLR2 21049294 665205 Positive_regulation MUC16 TLR2 21611194 2523801 Positive_regulation MUC16 TLR2 22566801 898567 Positive_regulation MUC16 TLR3 PMC3552307 92131 Positive_regulation MUC16 TMPRSS11D 22916223 2680222 Positive_regulation MUC16 TNF 12482999 1634077 Positive_regulation MUC16 TNF 17391532 3108195 Positive_regulation MUC16 TNF 19668469 649378 Positive_regulation MUC16 TNF 22577246 1749742 Positive_regulation MUC16 TNF 22577246 1749743 Positive_regulation MUC16 TNF 22577246 1749773 Positive_regulation MUC16 TNF 22577246 1749866 Positive_regulation MUC16 TNF 24348668 3204689 Positive_regulation MUC16 TNF 24348668 3204690 Positive_regulation MUC16 TNF 24348668 3204691 Positive_regulation MUC16 TNF 24348668 3204736 Positive_regulation MUC16 TNF 24348668 3204737 Positive_regulation MUC16 TNF 25147434 1761097 Positive_regulation MUC16 TNF 25489420 206823 Positive_regulation MUC16 TNF 25489420 206824 Positive_regulation MUC16 TNF 25489420 206825 Positive_regulation MUC16 TNF 25489420 206867 Positive_regulation MUC16 TNF 25489420 206888 Positive_regulation MUC16 TNF 25489420 206921 Positive_regulation MUC16 TNF 25489420 206937 Positive_regulation MUC16 TNF 9400742 797497 Positive_regulation MUC16 TRPA1 22016736 950500 Positive_regulation MUC16 TRPM5 23741618 749231 Positive_regulation MUC16 UTP15 22914501 450777 Positive_regulation MUC16 UTP15 23484122 179532 Positive_regulation MUC16 UTP18 22914501 450775 Positive_regulation MUC16 UTP18 23484122 179530 Positive_regulation MUC16 UTP20 22914501 450773 Positive_regulation MUC16 UTP20 23484122 179528 Positive_regulation MUC16 UTP23 22914501 450778 Positive_regulation MUC16 UTP23 23484122 179533 Positive_regulation MUC16 UTP3 22914501 450776 Positive_regulation MUC16 UTP3 23484122 179531 Positive_regulation MUC16 UTP6 22914501 450774 Positive_regulation MUC16 UTP6 23484122 179529 Positive_regulation MUC16 VAMP8 24065956 879234 Positive_regulation MUC16 WDR61 19434244 646199 Positive_regulation MUC17 AGR2 22514630 2619559 Positive_regulation MUC17 AGR2 22945649 2148349 Positive_regulation MUC17 AGR2 23635006 473263 Positive_regulation MUC17 EPHB2 12482999 1633097 Positive_regulation MUC17 EPHB2 12482999 1633098 Positive_regulation MUC17 EPHB2 12482999 1633695 Positive_regulation MUC17 EPHB2 16491824 1711325 Positive_regulation MUC17 MAP2K6 12482999 1633106 Positive_regulation MUC17 MAP2K6 12482999 1633703 Positive_regulation MUC17 MMP28 20920189 3111068 Positive_regulation MUC17 MMP7 20920189 3111083 Positive_regulation MUC17 TNF 12482999 1634079 Positive_regulation MUC17 TNF 17391532 3108196 Positive_regulation MUC17 TNF 19668469 649379 Positive_regulation MUC17 TNF 22577246 1749744 Positive_regulation MUC17 TNF 22577246 1749745 Positive_regulation MUC17 TNF 22577246 1749774 Positive_regulation MUC17 TNF 22577246 1749867 Positive_regulation MUC17 TNF 24348668 3204692 Positive_regulation MUC17 TNF 24348668 3204693 Positive_regulation MUC17 TNF 24348668 3204694 Positive_regulation MUC17 TNF 24348668 3204738 Positive_regulation MUC17 TNF 24348668 3204739 Positive_regulation MUC17 TNF 25147434 1761098 Positive_regulation MUC17 TNF 25489420 206826 Positive_regulation MUC17 TNF 25489420 206827 Positive_regulation MUC17 TNF 25489420 206828 Positive_regulation MUC17 TNF 25489420 206868 Positive_regulation MUC17 TNF 25489420 206889 Positive_regulation MUC17 TNF 25489420 206922 Positive_regulation MUC17 TNF 25489420 206938 Positive_regulation MUC17 TNF 9400742 797501 Positive_regulation MUC19 AGR2 22514630 2619556 Positive_regulation MUC19 AGR2 22945649 2148346 Positive_regulation MUC19 AGR2 23635006 473260 Positive_regulation MUC19 EPHB2 12482999 1633019 Positive_regulation MUC19 EPHB2 12482999 1633020 Positive_regulation MUC19 EPHB2 12482999 1633653 Positive_regulation MUC19 EPHB2 16491824 1711322 Positive_regulation MUC19 MAP2K6 12482999 1633028 Positive_regulation MUC19 MAP2K6 12482999 1633661 Positive_regulation MUC19 MMP28 20920189 3111002 Positive_regulation MUC19 MMP7 20920189 3111017 Positive_regulation MUC19 TNF 12482999 1634073 Positive_regulation MUC19 TNF 17391532 3108193 Positive_regulation MUC19 TNF 19668469 649376 Positive_regulation MUC19 TNF 22577246 1749738 Positive_regulation MUC19 TNF 22577246 1749739 Positive_regulation MUC19 TNF 22577246 1749771 Positive_regulation MUC19 TNF 22577246 1749864 Positive_regulation MUC19 TNF 24348668 3204683 Positive_regulation MUC19 TNF 24348668 3204684 Positive_regulation MUC19 TNF 24348668 3204685 Positive_regulation MUC19 TNF 24348668 3204732 Positive_regulation MUC19 TNF 24348668 3204733 Positive_regulation MUC19 TNF 25147434 1761095 Positive_regulation MUC19 TNF 25489420 206814 Positive_regulation MUC19 TNF 25489420 206815 Positive_regulation MUC19 TNF 25489420 206816 Positive_regulation MUC19 TNF 25489420 206865 Positive_regulation MUC19 TNF 25489420 206886 Positive_regulation MUC19 TNF 25489420 206918 Positive_regulation MUC19 TNF 25489420 206935 Positive_regulation MUC19 TNF 9400742 797489 Positive_regulation MUC2 AGR2 22514630 2619566 Positive_regulation MUC2 AGR2 22945649 2148370 Positive_regulation MUC2 AGR2 23635006 473272 Positive_regulation MUC2 AGR2 25111734 2996334 Positive_regulation MUC2 AGR2 25111734 2996335 Positive_regulation MUC2 EPHB2 12482999 1633311 Positive_regulation MUC2 EPHB2 12482999 1633312 Positive_regulation MUC2 EPHB2 12482999 1633313 Positive_regulation MUC2 EPHB2 12482999 1633819 Positive_regulation MUC2 EPHB2 16491824 1711332 Positive_regulation MUC2 EPHB2 24498386 2919301 Positive_regulation MUC2 EPHB2 24944587 1021487 Positive_regulation MUC2 MAP2K6 12482999 1633321 Positive_regulation MUC2 MAP2K6 12482999 1633828 Positive_regulation MUC2 MAP2K6 24944587 1021493 Positive_regulation MUC2 MMP28 20920189 3111222 Positive_regulation MUC2 MMP7 20920189 3111237 Positive_regulation MUC2 TNF 12482999 1634007 Positive_regulation MUC2 TNF 12482999 1634135 Positive_regulation MUC2 TNF 16504136 3106724 Positive_regulation MUC2 TNF 17391532 3108203 Positive_regulation MUC2 TNF 19668469 649386 Positive_regulation MUC2 TNF 20703838 668671 Positive_regulation MUC2 TNF 22417007 360733 Positive_regulation MUC2 TNF 22577246 1749758 Positive_regulation MUC2 TNF 22577246 1749759 Positive_regulation MUC2 TNF 22577246 1749781 Positive_regulation MUC2 TNF 22577246 1749874 Positive_regulation MUC2 TNF 23723167 780901 Positive_regulation MUC2 TNF 23723167 780905 Positive_regulation MUC2 TNF 24348668 3204713 Positive_regulation MUC2 TNF 24348668 3204714 Positive_regulation MUC2 TNF 24348668 3204715 Positive_regulation MUC2 TNF 24348668 3204752 Positive_regulation MUC2 TNF 24348668 3204753 Positive_regulation MUC2 TNF 24694941 1703524 Positive_regulation MUC2 TNF 25147434 1761105 Positive_regulation MUC2 TNF 25489420 206847 Positive_regulation MUC2 TNF 25489420 206848 Positive_regulation MUC2 TNF 25489420 206849 Positive_regulation MUC2 TNF 25489420 206881 Positive_regulation MUC2 TNF 25489420 206896 Positive_regulation MUC2 TNF 25489420 206929 Positive_regulation MUC2 TNF 25489420 206945 Positive_regulation MUC2 TNF 9400742 797529 Positive_regulation MUC20 AGR2 22514630 2619561 Positive_regulation MUC20 AGR2 22945649 2148351 Positive_regulation MUC20 AGR2 23635006 473265 Positive_regulation MUC20 EPHB2 12482999 1633151 Positive_regulation MUC20 EPHB2 12482999 1633152 Positive_regulation MUC20 EPHB2 12482999 1633723 Positive_regulation MUC20 EPHB2 16491824 1711327 Positive_regulation MUC20 MAP2K6 12482999 1633160 Positive_regulation MUC20 MAP2K6 12482999 1633731 Positive_regulation MUC20 MMP28 20920189 3111112 Positive_regulation MUC20 MMP7 20920189 3111127 Positive_regulation MUC20 TNF 12482999 1634097 Positive_regulation MUC20 TNF 17391532 3108198 Positive_regulation MUC20 TNF 19668469 649381 Positive_regulation MUC20 TNF 22577246 1749748 Positive_regulation MUC20 TNF 22577246 1749749 Positive_regulation MUC20 TNF 22577246 1749776 Positive_regulation MUC20 TNF 22577246 1749869 Positive_regulation MUC20 TNF 24348668 3204698 Positive_regulation MUC20 TNF 24348668 3204699 Positive_regulation MUC20 TNF 24348668 3204700 Positive_regulation MUC20 TNF 24348668 3204742 Positive_regulation MUC20 TNF 24348668 3204743 Positive_regulation MUC20 TNF 25147434 1761100 Positive_regulation MUC20 TNF 25489420 206832 Positive_regulation MUC20 TNF 25489420 206833 Positive_regulation MUC20 TNF 25489420 206834 Positive_regulation MUC20 TNF 25489420 206871 Positive_regulation MUC20 TNF 25489420 206891 Positive_regulation MUC20 TNF 25489420 206924 Positive_regulation MUC20 TNF 25489420 206940 Positive_regulation MUC20 TNF 9400742 797509 Positive_regulation MUC21 AGR2 22514630 2619560 Positive_regulation MUC21 AGR2 22945649 2148350 Positive_regulation MUC21 AGR2 23635006 473264 Positive_regulation MUC21 EPHB2 12482999 1633125 Positive_regulation MUC21 EPHB2 12482999 1633126 Positive_regulation MUC21 EPHB2 12482999 1633709 Positive_regulation MUC21 EPHB2 16491824 1711326 Positive_regulation MUC21 MAP2K6 12482999 1633134 Positive_regulation MUC21 MAP2K6 12482999 1633717 Positive_regulation MUC21 MMP28 20920189 3111090 Positive_regulation MUC21 MMP7 20920189 3111105 Positive_regulation MUC21 TNF 12482999 1634095 Positive_regulation MUC21 TNF 17391532 3108197 Positive_regulation MUC21 TNF 19668469 649380 Positive_regulation MUC21 TNF 22577246 1749746 Positive_regulation MUC21 TNF 22577246 1749747 Positive_regulation MUC21 TNF 22577246 1749775 Positive_regulation MUC21 TNF 22577246 1749868 Positive_regulation MUC21 TNF 24348668 3204695 Positive_regulation MUC21 TNF 24348668 3204696 Positive_regulation MUC21 TNF 24348668 3204697 Positive_regulation MUC21 TNF 24348668 3204740 Positive_regulation MUC21 TNF 24348668 3204741 Positive_regulation MUC21 TNF 25147434 1761099 Positive_regulation MUC21 TNF 25489420 206829 Positive_regulation MUC21 TNF 25489420 206830 Positive_regulation MUC21 TNF 25489420 206831 Positive_regulation MUC21 TNF 25489420 206870 Positive_regulation MUC21 TNF 25489420 206890 Positive_regulation MUC21 TNF 25489420 206923 Positive_regulation MUC21 TNF 25489420 206939 Positive_regulation MUC21 TNF 9400742 797505 Positive_regulation MUC22 AGR2 22514630 2619562 Positive_regulation MUC22 AGR2 22945649 2148353 Positive_regulation MUC22 AGR2 23635006 473268 Positive_regulation MUC22 EPHB2 12482999 1633182 Positive_regulation MUC22 EPHB2 12482999 1633183 Positive_regulation MUC22 EPHB2 12482999 1633739 Positive_regulation MUC22 EPHB2 16491824 1711328 Positive_regulation MUC22 MAP2K6 12482999 1633191 Positive_regulation MUC22 MAP2K6 12482999 1633747 Positive_regulation MUC22 MMP28 20920189 3111134 Positive_regulation MUC22 MMP7 20920189 3111149 Positive_regulation MUC22 TNF 12482999 1634127 Positive_regulation MUC22 TNF 17391532 3108199 Positive_regulation MUC22 TNF 19668469 649382 Positive_regulation MUC22 TNF 22577246 1749750 Positive_regulation MUC22 TNF 22577246 1749751 Positive_regulation MUC22 TNF 22577246 1749777 Positive_regulation MUC22 TNF 22577246 1749870 Positive_regulation MUC22 TNF 24348668 3204701 Positive_regulation MUC22 TNF 24348668 3204702 Positive_regulation MUC22 TNF 24348668 3204703 Positive_regulation MUC22 TNF 24348668 3204744 Positive_regulation MUC22 TNF 24348668 3204745 Positive_regulation MUC22 TNF 25147434 1761101 Positive_regulation MUC22 TNF 25489420 206835 Positive_regulation MUC22 TNF 25489420 206836 Positive_regulation MUC22 TNF 25489420 206837 Positive_regulation MUC22 TNF 25489420 206872 Positive_regulation MUC22 TNF 25489420 206892 Positive_regulation MUC22 TNF 25489420 206925 Positive_regulation MUC22 TNF 25489420 206941 Positive_regulation MUC22 TNF 9400742 797513 Positive_regulation MUC4 AGR2 22514630 2619567 Positive_regulation MUC4 AGR2 22945649 2148371 Positive_regulation MUC4 AGR2 23635006 473273 Positive_regulation MUC4 EPHB2 12482999 1633350 Positive_regulation MUC4 EPHB2 12482999 1633351 Positive_regulation MUC4 EPHB2 12482999 1633834 Positive_regulation MUC4 EPHB2 16491824 1711333 Positive_regulation MUC4 IFI27 23136569 1713787 Positive_regulation MUC4 MAP2K6 12482999 1633359 Positive_regulation MUC4 MAP2K6 12482999 1633842 Positive_regulation MUC4 MAP2K6 22537161 1865636 Positive_regulation MUC4 MMP28 20920189 3111244 Positive_regulation MUC4 MMP7 20920189 3111259 Positive_regulation MUC4 MUC16 22537161 1865605 Positive_regulation MUC4 TNF 12482999 1634137 Positive_regulation MUC4 TNF 17391532 3108204 Positive_regulation MUC4 TNF 19668469 649387 Positive_regulation MUC4 TNF 22577246 1749760 Positive_regulation MUC4 TNF 22577246 1749761 Positive_regulation MUC4 TNF 22577246 1749782 Positive_regulation MUC4 TNF 22577246 1749875 Positive_regulation MUC4 TNF 24348668 3204716 Positive_regulation MUC4 TNF 24348668 3204717 Positive_regulation MUC4 TNF 24348668 3204718 Positive_regulation MUC4 TNF 24348668 3204754 Positive_regulation MUC4 TNF 24348668 3204755 Positive_regulation MUC4 TNF 25147434 1761106 Positive_regulation MUC4 TNF 25489420 206850 Positive_regulation MUC4 TNF 25489420 206851 Positive_regulation MUC4 TNF 25489420 206852 Positive_regulation MUC4 TNF 25489420 206882 Positive_regulation MUC4 TNF 25489420 206897 Positive_regulation MUC4 TNF 25489420 206930 Positive_regulation MUC4 TNF 25489420 206946 Positive_regulation MUC4 TNF 9400742 797533 Positive_regulation MUC5AC EPHB2 16491824 1711334 Positive_regulation MUC5AC EPHB2 24498386 2919307 Positive_regulation MUC5AC MUC16 16491824 1710913 Positive_regulation MUC5AC MUC16 17029558 2303247 Positive_regulation MUC5AC MUC16 17029558 2303356 Positive_regulation MUC5AC TLR7 22303480 2594772 Positive_regulation MUC5AC TLR7 22303480 2594773 Positive_regulation MUC5AC TLR7 22303480 2594774 Positive_regulation MUC5AC TLR7 22303480 2594775 Positive_regulation MUC5AC TLR7 22303480 2594776 Positive_regulation MUC5AC TLR7 22303480 2594851 Positive_regulation MUC5AC TLR7 22303480 2594861 Positive_regulation MUC5AC TLR7 22303480 2594886 Positive_regulation MUC5AC TLR7 22303480 2594969 Positive_regulation MUC5AC TLR7 22303480 2594970 Positive_regulation MUC5AC TLR7 22303480 2594971 Positive_regulation MUC5AC TLR7 22303480 2594972 Positive_regulation MUC5AC TLR7 22303480 2595020 Positive_regulation MUC5AC TLR7 22303480 2595021 Positive_regulation MUC5AC TLR7 22303480 2595022 Positive_regulation MUC5AC TLR7 22303480 2595023 Positive_regulation MUC5AC TLR7 22303480 2595069 Positive_regulation MUC5AC TNF 19668469 649356 Positive_regulation MUC5AC TNF 22303480 2594885 Positive_regulation MUC5AC TNF 22577246 1749762 Positive_regulation MUC5AC TNF 22577246 1749770 Positive_regulation MUC5AC TNF 22577246 1749783 Positive_regulation MUC5AC TNF 22577246 1749788 Positive_regulation MUC5AC TNF 22577246 1749876 Positive_regulation MUC5AC TNF 23843693 162184 Positive_regulation MUC5AC TNF 23843693 162185 Positive_regulation MUC5AC TNF 24348668 3204719 Positive_regulation MUC5AC TNF 24348668 3204720 Positive_regulation MUC5AC TNF 24348668 3204721 Positive_regulation MUC5AC TNF 24348668 3204756 Positive_regulation MUC5AC TNF 24348668 3204757 Positive_regulation MUC5AC TNF 25398130 3027512 Positive_regulation MUC5AC TNF 25398130 3027515 Positive_regulation MUC5AC TNF 25489420 206853 Positive_regulation MUC5AC TNF 25489420 206854 Positive_regulation MUC5AC TNF 25489420 206855 Positive_regulation MUC5AC TNF 25489420 206931 Positive_regulation MUC5B TNF 25398130 3027513 Positive_regulation MUC6 AGR2 22514630 2619568 Positive_regulation MUC6 AGR2 22945649 2148372 Positive_regulation MUC6 AGR2 23635006 473274 Positive_regulation MUC6 EPHB2 12482999 1633376 Positive_regulation MUC6 EPHB2 12482999 1633377 Positive_regulation MUC6 EPHB2 12482999 1633848 Positive_regulation MUC6 EPHB2 16491824 1711335 Positive_regulation MUC6 MAP2K6 12482999 1633385 Positive_regulation MUC6 MAP2K6 12482999 1633856 Positive_regulation MUC6 MMP28 20920189 3111266 Positive_regulation MUC6 MMP7 20920189 3111281 Positive_regulation MUC6 TNF 12482999 1634139 Positive_regulation MUC6 TNF 17391532 3108205 Positive_regulation MUC6 TNF 19668469 649388 Positive_regulation MUC6 TNF 22577246 1749763 Positive_regulation MUC6 TNF 22577246 1749764 Positive_regulation MUC6 TNF 22577246 1749784 Positive_regulation MUC6 TNF 22577246 1749877 Positive_regulation MUC6 TNF 24348668 3204722 Positive_regulation MUC6 TNF 24348668 3204723 Positive_regulation MUC6 TNF 24348668 3204724 Positive_regulation MUC6 TNF 24348668 3204758 Positive_regulation MUC6 TNF 24348668 3204759 Positive_regulation MUC6 TNF 25147434 1761107 Positive_regulation MUC6 TNF 25489420 206856 Positive_regulation MUC6 TNF 25489420 206857 Positive_regulation MUC6 TNF 25489420 206858 Positive_regulation MUC6 TNF 25489420 206883 Positive_regulation MUC6 TNF 25489420 206898 Positive_regulation MUC6 TNF 25489420 206932 Positive_regulation MUC6 TNF 25489420 206947 Positive_regulation MUC6 TNF 9400742 797537 Positive_regulation MUC7 AGR2 22514630 2619569 Positive_regulation MUC7 AGR2 22945649 2148373 Positive_regulation MUC7 AGR2 23635006 473275 Positive_regulation MUC7 EPHB2 12482999 1633402 Positive_regulation MUC7 EPHB2 12482999 1633403 Positive_regulation MUC7 EPHB2 12482999 1633862 Positive_regulation MUC7 EPHB2 16491824 1711336 Positive_regulation MUC7 ITGAL 1370839 1297787 Positive_regulation MUC7 MAP2K6 12482999 1633411 Positive_regulation MUC7 MAP2K6 12482999 1633870 Positive_regulation MUC7 MMP28 20920189 3111288 Positive_regulation MUC7 MMP7 20920189 3111303 Positive_regulation MUC7 TGM2 24921197 653861 Positive_regulation MUC7 TNF 12482999 1634141 Positive_regulation MUC7 TNF 17391532 3108206 Positive_regulation MUC7 TNF 19668469 649389 Positive_regulation MUC7 TNF 22577246 1749765 Positive_regulation MUC7 TNF 22577246 1749766 Positive_regulation MUC7 TNF 22577246 1749785 Positive_regulation MUC7 TNF 22577246 1749878 Positive_regulation MUC7 TNF 24348668 3204725 Positive_regulation MUC7 TNF 24348668 3204726 Positive_regulation MUC7 TNF 24348668 3204727 Positive_regulation MUC7 TNF 24348668 3204760 Positive_regulation MUC7 TNF 24348668 3204761 Positive_regulation MUC7 TNF 25147434 1761108 Positive_regulation MUC7 TNF 25489420 206859 Positive_regulation MUC7 TNF 25489420 206860 Positive_regulation MUC7 TNF 25489420 206861 Positive_regulation MUC7 TNF 25489420 206884 Positive_regulation MUC7 TNF 25489420 206899 Positive_regulation MUC7 TNF 25489420 206933 Positive_regulation MUC7 TNF 25489420 206948 Positive_regulation MUC7 TNF 9400742 797541 Positive_regulation MUC8 AGR2 22514630 2619570 Positive_regulation MUC8 AGR2 22945649 2148374 Positive_regulation MUC8 AGR2 23635006 473276 Positive_regulation MUC8 EPHB2 12482999 1633428 Positive_regulation MUC8 EPHB2 12482999 1633429 Positive_regulation MUC8 EPHB2 12482999 1633876 Positive_regulation MUC8 EPHB2 16491824 1711337 Positive_regulation MUC8 MAP2K6 12482999 1633437 Positive_regulation MUC8 MAP2K6 12482999 1633884 Positive_regulation MUC8 MMP28 20920189 3111310 Positive_regulation MUC8 MMP7 20920189 3111325 Positive_regulation MUC8 TNF 12482999 1634143 Positive_regulation MUC8 TNF 17391532 3108207 Positive_regulation MUC8 TNF 19668469 649390 Positive_regulation MUC8 TNF 22577246 1749767 Positive_regulation MUC8 TNF 22577246 1749768 Positive_regulation MUC8 TNF 22577246 1749786 Positive_regulation MUC8 TNF 22577246 1749879 Positive_regulation MUC8 TNF 24348668 3204728 Positive_regulation MUC8 TNF 24348668 3204729 Positive_regulation MUC8 TNF 24348668 3204730 Positive_regulation MUC8 TNF 24348668 3204762 Positive_regulation MUC8 TNF 24348668 3204763 Positive_regulation MUC8 TNF 25147434 1761109 Positive_regulation MUC8 TNF 25489420 206862 Positive_regulation MUC8 TNF 25489420 206863 Positive_regulation MUC8 TNF 25489420 206864 Positive_regulation MUC8 TNF 25489420 206885 Positive_regulation MUC8 TNF 25489420 206900 Positive_regulation MUC8 TNF 25489420 206934 Positive_regulation MUC8 TNF 25489420 206949 Positive_regulation MUC8 TNF 9400742 797545 Positive_regulation MUT FOXO1 22496671 2334610 Positive_regulation MUT TNF 21980470 2560879 Positive_regulation MUT TNF 23771139 2089824 Positive_regulation MX2 ABCB1 10070877 414025 Positive_regulation MX2 IL1A 22235868 335742 Positive_regulation MX2 IRF7 22235868 335743 Positive_regulation MXD1 EPHB2 23437333 2756496 Positive_regulation MYBL1 TNF 23049873 2699759 Positive_regulation MYBPC1 FBXO32 22028912 2565137 Positive_regulation MYBPC2 FBXO32 22028912 2565139 Positive_regulation MYBPC3 FBXO32 22028912 2565141 Positive_regulation MYC AXIN2 19262462 764068 Positive_regulation MYC CCND1 23344177 1905729 Positive_regulation MYC CCND1 23390492 2750677 Positive_regulation MYC CCND1 25047753 240977 Positive_regulation MYC CTGF 23681229 561795 Positive_regulation MYC CTGF 23681229 561807 Positive_regulation MYC EPHB2 15811177 1844545 Positive_regulation MYC EPHB2 16899113 1845498 Positive_regulation MYC EPHB2 16899113 1845514 Positive_regulation MYC EPHB2 18463697 2289722 Positive_regulation MYC EPHB2 18463697 2289729 Positive_regulation MYC EPHB2 18463697 2289731 Positive_regulation MYC EPHB2 22375140 924205 Positive_regulation MYC EPHB2 23300995 2737822 Positive_regulation MYC EPHB2 23365639 2745325 Positive_regulation MYC EPHB2 23437333 2756468 Positive_regulation MYC EPHB2 23437333 2756497 Positive_regulation MYC EPHB2 24250280 2299055 Positive_regulation MYC EPHB2 24416646 1708133 Positive_regulation MYC EPHB2 24457827 2186899 Positive_regulation MYC EPHB2 24550252 752877 Positive_regulation MYC EPHB2 25250015 881137 Positive_regulation MYC ID1 24137437 2165748 Positive_regulation MYC IFI27 24976536 1483672 Positive_regulation MYC IFI27 24976536 1483696 Positive_regulation MYC KRT38 25433490 349817 Positive_regulation MYC MAP2K6 16899113 1845504 Positive_regulation MYC MAP2K6 23437333 2756477 Positive_regulation MYC MAP2K6 24550252 752883 Positive_regulation MYC TNFSF10 21513580 1861752 Positive_regulation MYC TNFSF10 21513580 1861813 Positive_regulation MYC TNFSF10 21513580 1861881 Positive_regulation MYCN EPHB2 21698133 2324846 Positive_regulation MYCN EPHB2 22337808 2179703 Positive_regulation MYCN EPHB2 9432981 1602453 Positive_regulation MYCN MAP2K6 24475138 2914922 Positive_regulation MYD88 EPHB2 25101851 2995837 Positive_regulation MYD88 MUC16 24527027 980906 Positive_regulation MYD88 TLR7 12591910 1526053 Positive_regulation MYD88 TLR7 18066067 1951755 Positive_regulation MYD88 TLR7 19343210 3043650 Positive_regulation MYD88 TLR7 19652017 1555510 Positive_regulation MYD88 TLR7 19801985 1953258 Positive_regulation MYD88 TLR7 20548099 1376778 Positive_regulation MYD88 TLR7 20668698 2457449 Positive_regulation MYD88 TLR7 21494372 1037897 Positive_regulation MYD88 TLR7 21573018 2520457 Positive_regulation MYD88 TLR7 21893536 2250064 Positive_regulation MYD88 TLR7 21994583 3218721 Positive_regulation MYD88 TLR7 22586164 91025 Positive_regulation MYD88 TLR7 22876248 903023 Positive_regulation MYD88 TLR7 23078795 1617323 Positive_regulation MYD88 TLR7 23263554 1958406 Positive_regulation MYD88 TLR7 23263554 1958416 Positive_regulation MYD88 TLR7 23514422 1683705 Positive_regulation MYD88 TLR7 23519558 906667 Positive_regulation MYD88 TLR7 24252328 178857 Positive_regulation MYD88 TLR7 24514026 773680 Positive_regulation MYD88 TLR7 24624130 911870 Positive_regulation MYD88 TLR7 24719558 1062621 Positive_regulation MYD88 TLR7 25050810 2991048 Positive_regulation MYD88 TNF 20714353 3048303 Positive_regulation MYD88 TNF 22523644 1680641 Positive_regulation MYF5 WNT7A 23818907 3174015 Positive_regulation MYH1 TNF 22476916 1238758 Positive_regulation MYH10 TNF 22476916 1238759 Positive_regulation MYH11 FHL1 19958749 145022 Positive_regulation MYH11 JAG1 22509166 957077 Positive_regulation MYH11 TNF 22476916 1238760 Positive_regulation MYH11 TNF 25045513 651818 Positive_regulation MYH13 TNF 22476916 1238761 Positive_regulation MYH14 TNF 22476916 1238755 Positive_regulation MYH15 TNF 22476916 1238757 Positive_regulation MYH16 CDK5 19534817 1227198 Positive_regulation MYH16 DNMT1 20081831 1984048 Positive_regulation MYH16 GADD45A 20081831 1984049 Positive_regulation MYH16 HUS1 17395641 2027251 Positive_regulation MYH16 KLF5 21951574 3112749 Positive_regulation MYH16 MSC 24710543 619476 Positive_regulation MYH16 PHOSPHO1 19862331 2429815 Positive_regulation MYH16 PHOSPHO2 19862331 2429816 Positive_regulation MYH16 RAD1 17395641 2027252 Positive_regulation MYH16 RAD9A 17395641 2027253 Positive_regulation MYH16 REPIN1 23935420 3154953 Positive_regulation MYH16 SIX1 24852826 2359313 Positive_regulation MYH16 SIX1 24852826 2359314 Positive_regulation MYH16 SIX1 24852826 2359315 Positive_regulation MYH16 SIX1 24852826 2359316 Positive_regulation MYH16 SIX1 24852826 2359317 Positive_regulation MYH16 SIX1 24852826 2359463 Positive_regulation MYH16 SRF 24385487 1413625 Positive_regulation MYH16 TAC1 23493786 1061303 Positive_regulation MYH16 TAC1 24086300 2853831 Positive_regulation MYH16 TAC3 23493786 1061304 Positive_regulation MYH16 TAC3 24086300 2853832 Positive_regulation MYH16 TAC4 23493786 1061305 Positive_regulation MYH16 TAC4 24086300 2853833 Positive_regulation MYH16 TNF 22476916 1238756 Positive_regulation MYH16 TRIM54 10953002 1261983 Positive_regulation MYH16 WNT3A 23497616 3161527 Positive_regulation MYH2 TNF 22476916 1238762 Positive_regulation MYH2 TNF 24453411 1756659 Positive_regulation MYH3 CDK5 19534817 1227205 Positive_regulation MYH3 DNMT1 20081831 1984062 Positive_regulation MYH3 GADD45A 20081831 1984063 Positive_regulation MYH3 HUS1 17395641 2027272 Positive_regulation MYH3 KLF5 21951574 3112756 Positive_regulation MYH3 MSC 24710543 619483 Positive_regulation MYH3 PHOSPHO1 19862331 2429829 Positive_regulation MYH3 PHOSPHO2 19862331 2429830 Positive_regulation MYH3 RAD1 17395641 2027273 Positive_regulation MYH3 RAD9A 17395641 2027274 Positive_regulation MYH3 REPIN1 23935420 3154960 Positive_regulation MYH3 SIX1 24852826 2359348 Positive_regulation MYH3 SIX1 24852826 2359349 Positive_regulation MYH3 SIX1 24852826 2359350 Positive_regulation MYH3 SIX1 24852826 2359351 Positive_regulation MYH3 SIX1 24852826 2359352 Positive_regulation MYH3 SIX1 24852826 2359470 Positive_regulation MYH3 SRF 24385487 1413636 Positive_regulation MYH3 TAC1 23493786 1061324 Positive_regulation MYH3 TAC1 24086300 2853852 Positive_regulation MYH3 TAC3 23493786 1061325 Positive_regulation MYH3 TAC3 24086300 2853853 Positive_regulation MYH3 TAC4 23493786 1061326 Positive_regulation MYH3 TAC4 24086300 2853854 Positive_regulation MYH3 TNF 22476916 1238763 Positive_regulation MYH3 TRIM54 10953002 1261990 Positive_regulation MYH3 WNT3A 23497616 3161534 Positive_regulation MYH4 TNF 22476916 1238764 Positive_regulation MYH6 TNF 22476916 1238765 Positive_regulation MYH6 TNNT2 24974728 1483594 Positive_regulation MYH7 TNF 22476916 1238766 Positive_regulation MYH8 TNF 22476916 1238767 Positive_regulation MYH9 ITGAL 18195072 1548556 Positive_regulation MYH9 TNF 22476916 1238768 Positive_regulation MYL1 EPHB2 10477763 1249190 Positive_regulation MYL1 EPHB2 10477763 1249330 Positive_regulation MYL1 EPHB2 22438881 2611775 Positive_regulation MYL1 EPHB2 24561478 3186754 Positive_regulation MYL1 MAP2K6 24561478 3186760 Positive_regulation MYL10 EPHB2 10477763 1249185 Positive_regulation MYL10 EPHB2 10477763 1249329 Positive_regulation MYL10 EPHB2 22438881 2611771 Positive_regulation MYL10 EPHB2 24561478 3186746 Positive_regulation MYL10 MAP2K6 24561478 3186752 Positive_regulation MYL12B EPHB2 23969997 839532 Positive_regulation MYL12B TNF 22688336 723185 Positive_regulation MYL12B TNF 22688336 723186 Positive_regulation MYL2 CTGF 24558600 1154265 Positive_regulation MYL2 EPHB2 10477763 1249193 Positive_regulation MYL2 EPHB2 10477763 1249331 Positive_regulation MYL2 EPHB2 22438881 2611779 Positive_regulation MYL2 EPHB2 24561478 3186762 Positive_regulation MYL2 MAP2K6 24561478 3186768 Positive_regulation MYL2 SRGN 18086913 1346869 Positive_regulation MYL3 EPHB2 10477763 1249196 Positive_regulation MYL3 EPHB2 10477763 1249332 Positive_regulation MYL3 EPHB2 22438881 2611783 Positive_regulation MYL3 EPHB2 24561478 3186770 Positive_regulation MYL3 MAP2K6 24561478 3186776 Positive_regulation MYL4 EPHB2 10477763 1249199 Positive_regulation MYL4 EPHB2 10477763 1249333 Positive_regulation MYL4 EPHB2 22438881 2611787 Positive_regulation MYL4 EPHB2 24561478 3186778 Positive_regulation MYL4 MAP2K6 24561478 3186784 Positive_regulation MYL5 EPHB2 10477763 1249202 Positive_regulation MYL5 EPHB2 10477763 1249334 Positive_regulation MYL5 EPHB2 22438881 2611791 Positive_regulation MYL5 EPHB2 24561478 3186786 Positive_regulation MYL5 MAP2K6 24561478 3186792 Positive_regulation MYL6 EPHB2 10477763 1249205 Positive_regulation MYL6 EPHB2 10477763 1249335 Positive_regulation MYL6 EPHB2 22438881 2611795 Positive_regulation MYL6 EPHB2 24561478 3186794 Positive_regulation MYL6 MAP2K6 24561478 3186800 Positive_regulation MYL7 EPHB2 10477763 1249182 Positive_regulation MYL7 EPHB2 10477763 1249328 Positive_regulation MYL7 EPHB2 22438881 2611767 Positive_regulation MYL7 EPHB2 24561478 3186738 Positive_regulation MYL7 MAP2K6 24561478 3186744 Positive_regulation MYL9 EDN2 18475617 1744670 Positive_regulation MYL9 EPHB2 10477763 1249179 Positive_regulation MYL9 EPHB2 10477763 1249327 Positive_regulation MYL9 EPHB2 22438881 2611763 Positive_regulation MYL9 EPHB2 24561478 3186730 Positive_regulation MYL9 MAP2K6 24561478 3186736 Positive_regulation MYLIP ABCG2 20628378 435657 Positive_regulation MYLIP CCND1 18695042 1354614 Positive_regulation MYLIP CCND1 18695042 1354617 Positive_regulation MYLIP CCND1 18695042 1354629 Positive_regulation MYLIP CCND1 18695042 1354634 Positive_regulation MYLIP CCND1 18695042 1354635 Positive_regulation MYLIP CCND1 18695042 1354636 Positive_regulation MYLIP CCND1 18695042 1354637 Positive_regulation MYLIP CCND1 20346098 465398 Positive_regulation MYLIP CCND1 21569481 1505326 Positive_regulation MYLIP CCND1 22389628 2278528 Positive_regulation MYLIP CCND1 22942717 1097074 Positive_regulation MYLIP CCND1 22942717 1097075 Positive_regulation MYLIP CCND1 23880895 606253 Positive_regulation MYLIP CCND1 24013378 1111760 Positive_regulation MYLIP CCND1 24528540 1507833 Positive_regulation MYLIP CCND1 24995320 194186 Positive_regulation MYLIP CCND1 25289101 2169771 Positive_regulation MYLIP CD14 24086639 2855269 Positive_regulation MYLIP CTGF 20393144 713772 Positive_regulation MYLIP CTGF 20393144 713779 Positive_regulation MYLIP CTGF 23681229 561811 Positive_regulation MYLIP CTGF 23750089 163594 Positive_regulation MYLIP EDN2 24575418 1495707 Positive_regulation MYLIP EPHB2 20041145 2435471 Positive_regulation MYLIP EPHB2 20041145 2435472 Positive_regulation MYLIP EPHB2 20041145 2435475 Positive_regulation MYLIP EPHB2 20444294 1228412 Positive_regulation MYLIP EPHB2 21266077 258526 Positive_regulation MYLIP EPHB2 21266476 2060288 Positive_regulation MYLIP EPHB2 22666537 3130598 Positive_regulation MYLIP EPHB2 23365639 2745343 Positive_regulation MYLIP EPHB2 23377548 16725 Positive_regulation MYLIP EPHB2 23469214 2763224 Positive_regulation MYLIP EPHB2 23469214 2763244 Positive_regulation MYLIP EPHB2 23469214 2763245 Positive_regulation MYLIP EPHB2 23469214 2763266 Positive_regulation MYLIP EPHB2 23469214 2763281 Positive_regulation MYLIP EPHB2 23633945 3060723 Positive_regulation MYLIP EPHB2 23633945 3060724 Positive_regulation MYLIP EPHB2 23633945 3060769 Positive_regulation MYLIP EPHB2 23633945 3060772 Positive_regulation MYLIP EPHB2 24349829 478320 Positive_regulation MYLIP EPHB2 24550252 752849 Positive_regulation MYLIP EPHB2 24550252 752850 Positive_regulation MYLIP EPHB2 24550252 752888 Positive_regulation MYLIP EPHB2 24550252 752889 Positive_regulation MYLIP EPHB2 24587182 2928992 Positive_regulation MYLIP EPHB2 25058005 2992043 Positive_regulation MYLIP EPHB2 25247240 1906162 Positive_regulation MYLIP EPHB2 25355277 1087851 Positive_regulation MYLIP FAS 25247240 1906007 Positive_regulation MYLIP FAS 25333257 2205581 Positive_regulation MYLIP FHL1 25414712 971831 Positive_regulation MYLIP FOXO1 19897564 162491 Positive_regulation MYLIP FOXO1 23748164 31260 Positive_regulation MYLIP FOXO1 23748164 31278 Positive_regulation MYLIP FOXO1 24735923 479757 Positive_regulation MYLIP FOXO1 25124875 1483788 Positive_regulation MYLIP IFI27 24727437 2188814 Positive_regulation MYLIP IFI27 24727437 2188823 Positive_regulation MYLIP IFI27 24727437 2188830 Positive_regulation MYLIP IFI27 24727437 2188843 Positive_regulation MYLIP IL1B 22536485 139672 Positive_regulation MYLIP IL1B 22536485 139675 Positive_regulation MYLIP ITGAL 24263102 569243 Positive_regulation MYLIP JAG1 21224847 768966 Positive_regulation MYLIP JAG1 22509166 957072 Positive_regulation MYLIP JAG1 22509166 957086 Positive_regulation MYLIP JAG1 23028429 2690512 Positive_regulation MYLIP KLF9 24349493 2898338 Positive_regulation MYLIP LAMB3 23320911 267328 Positive_regulation MYLIP MAP2K6 21987635 1392517 Positive_regulation MYLIP MAP2K6 22911796 2676675 Positive_regulation MYLIP MAP2K6 24550252 752861 Positive_regulation MYLIP MAP2K6 24550252 752862 Positive_regulation MYLIP MAP2K6 24550252 752900 Positive_regulation MYLIP MAP2K6 24550252 752901 Positive_regulation MYLIP NEDD9 25124875 1483825 Positive_regulation MYLIP NES 23016664 387854 Positive_regulation MYLIP NR2F1 24349493 2898334 Positive_regulation MYLIP NR2F1 24349493 2898339 Positive_regulation MYLIP NR2F1 24349493 2898348 Positive_regulation MYLIP PGC 20724363 1682595 Positive_regulation MYLIP PLAU 23864708 1816976 Positive_regulation MYLIP S100B 24725992 3169953 Positive_regulation MYLIP TLR7 19390647 1746601 Positive_regulation MYLIP TLR7 20041145 2435407 Positive_regulation MYLIP TLR7 20041145 2435408 Positive_regulation MYLIP TLR7 20041145 2435454 Positive_regulation MYLIP TLR7 20144951 2052331 Positive_regulation MYLIP TLR7 20525168 3110435 Positive_regulation MYLIP TLR7 21029443 3111568 Positive_regulation MYLIP TLR7 21188194 139544 Positive_regulation MYLIP TLR7 21494372 1037887 Positive_regulation MYLIP TLR7 22661952 957356 Positive_regulation MYLIP TLR7 22916300 2680756 Positive_regulation MYLIP TLR7 23078795 1617407 Positive_regulation MYLIP TLR7 23078795 1617514 Positive_regulation MYLIP TLR7 23259069 1719037 Positive_regulation MYLIP TLR7 23372573 883410 Positive_regulation MYLIP TLR7 23379780 127928 Positive_regulation MYLIP TLR7 23516655 2371813 Positive_regulation MYLIP TLR7 23762086 637684 Positive_regulation MYLIP TLR7 23951138 2833517 Positive_regulation MYLIP TLR7 23983769 638440 Positive_regulation MYLIP TLR7 23988154 3122235 Positive_regulation MYLIP TLR7 24351865 1122527 Positive_regulation MYLIP TLR7 24682221 2947147 Positive_regulation MYLIP TLR7 24682221 2947169 Positive_regulation MYLIP TLR7 24705038 2948703 Positive_regulation MYLIP TLR7 24800242 190044 Positive_regulation MYLIP TLR7 25295261 200769 Positive_regulation MYLIP TLR7 25484882 921383 Positive_regulation MYLIP TLR7 25484882 921446 Positive_regulation MYLIP TLR7 25484882 921447 Positive_regulation MYLIP TLR7 PMC3109490 927558 Positive_regulation MYLIP TNF 18947370 111638 Positive_regulation MYLIP TNF 19701459 2424377 Positive_regulation MYLIP TNF 19701459 2424379 Positive_regulation MYLIP TNF 19918258 1041628 Positive_regulation MYLIP TNF 20459811 118930 Positive_regulation MYLIP TNF 21029443 3111547 Positive_regulation MYLIP TNF 21029443 3111567 Positive_regulation MYLIP TNF 21029443 3111577 Positive_regulation MYLIP TNF 21572107 2063122 Positive_regulation MYLIP TNF 21747943 2534754 Positive_regulation MYLIP TNF 21789961 1143080 Positive_regulation MYLIP TNF 22010574 1143112 Positive_regulation MYLIP TNF 22048267 737008 Positive_regulation MYLIP TNF 22536485 139671 Positive_regulation MYLIP TNF 22536485 139674 Positive_regulation MYLIP TNF 22615562 3056754 Positive_regulation MYLIP TNF 22950459 1664994 Positive_regulation MYLIP TNF 22953717 337410 Positive_regulation MYLIP TNF 23056947 1145808 Positive_regulation MYLIP TNF 23437179 2755936 Positive_regulation MYLIP TNF 23441172 2756962 Positive_regulation MYLIP TNF 23448104 1231968 Positive_regulation MYLIP TNF 23448104 1231969 Positive_regulation MYLIP TNF 23448136 245410 Positive_regulation MYLIP TNF 23592910 1915767 Positive_regulation MYLIP TNF 23733368 780926 Positive_regulation MYLIP TNF 23852016 1108373 Positive_regulation MYLIP TNF 23983769 638447 Positive_regulation MYLIP TNF 24086143 2350867 Positive_regulation MYLIP TNF 24151514 638659 Positive_regulation MYLIP TNF 24151514 638660 Positive_regulation MYLIP TNF 24191129 737564 Positive_regulation MYLIP TNF 24349514 2898385 Positive_regulation MYLIP TNF 24369540 1495485 Positive_regulation MYLIP TNF 24587348 2929696 Positive_regulation MYLIP TNF 24688608 2208350 Positive_regulation MYLIP TNF 24744457 738410 Positive_regulation MYLIP TNF 24885472 1701850 Positive_regulation MYLIP TNF 24885472 1701863 Positive_regulation MYLIP TNF 24885472 1701870 Positive_regulation MYLIP TNF 24885472 1701872 Positive_regulation MYLIP TNF 24971753 2985024 Positive_regulation MYLIP TNF 24971753 2985079 Positive_regulation MYLIP TNF 24971753 2985094 Positive_regulation MYLIP TNF 25175907 3114868 Positive_regulation MYLIP TNF 25175907 3114893 Positive_regulation MYLIP TNF 25182190 381603 Positive_regulation MYLIP TNF 25182190 381608 Positive_regulation MYLIP TNFSF10 22303357 881743 Positive_regulation MYLIP TNFSF10 25015549 2195769 Positive_regulation MYLIP TNFSF10 25395862 2123729 Positive_regulation MYLIP TP63 23555954 2776093 Positive_regulation MYLIP TP63 23575763 787967 Positive_regulation MYLIP TP63 23710361 1690491 Positive_regulation MYLIP TP63 24396276 679775 Positive_regulation MYLIP TP63 25168241 549183 Positive_regulation MYLIP WIF1 24755295 1873936 Positive_regulation MYLIP WIF1 24755295 1873939 Positive_regulation MYLIP WIF1 24853424 576263 Positive_regulation MYLIP WIF1 24853424 576264 Positive_regulation MYLIP WIF1 24853424 576265 Positive_regulation MYLIP WNT7A 23862015 169982 Positive_regulation MYLIP WNT7A 23862015 169983 Positive_regulation MYLIP WNT7A 23862015 169984 Positive_regulation MYLIP WNT7A 23862015 169985 Positive_regulation MYLIP WNT7A 23862015 169986 Positive_regulation MYLIP WNT7A 23862015 169987 Positive_regulation MYLIP WNT7A 23862015 169988 Positive_regulation MYLIP WNT7A 23862015 170026 Positive_regulation MYLIP WNT7A 23862015 170027 Positive_regulation MYLIP WNT7A 23862015 170028 Positive_regulation MYLIP WNT7A 23862015 170029 Positive_regulation MYLIP WNT7A 23862015 170042 Positive_regulation MYLIP WNT7A 23862015 170054 Positive_regulation MYLIP WNT7A 23862015 170055 Positive_regulation MYLIP WNT7A 23862015 170056 Positive_regulation MYLIP WNT7A 23862015 170065 Positive_regulation MYLIP WNT7A 23862015 170066 Positive_regulation MYLIP WNT7A 23862015 170069 Positive_regulation MYLIP WNT7A 23862015 170079 Positive_regulation MYLK EPHB2 10747099 1257021 Positive_regulation MYLK EPHB2 11266465 1269107 Positive_regulation MYLK EPHB2 18793427 281736 Positive_regulation MYLK EPHB2 21560073 600080 Positive_regulation MYLK EPHB2 22970259 2687892 Positive_regulation MYLK EPHB2 23467882 1879472 Positive_regulation MYLK EPHB2 23969997 839535 Positive_regulation MYLK EPHB2 24116218 2865829 Positive_regulation MYLK EPHB2 24561478 3186802 Positive_regulation MYLK EPHB2 24709902 617309 Positive_regulation MYLK EPHB2 9128257 1459896 Positive_regulation MYLK EPHB2 9128257 1459899 Positive_regulation MYLK MAP2K6 24561478 3186808 Positive_regulation MYLK PLAU 10402467 1248051 Positive_regulation MYLK TNF 20453870 9928 Positive_regulation MYLK TNF 22031828 2565233 Positive_regulation MYLK TNF 22228679 777063 Positive_regulation MYLK TNF 22228679 777067 Positive_regulation MYLK TNF 22228679 777074 Positive_regulation MYLK TNF 23964209 921905 Positive_regulation MYLK TNF 24392360 864822 Positive_regulation MYLK TNF 24520376 2921507 Positive_regulation MYO10 CAPN8 24489676 2915653 Positive_regulation MYO10 CAPN8 24489676 2915861 Positive_regulation MYO10 EPHB2 10648571 1255618 Positive_regulation MYO10 EPHB2 18793427 281700 Positive_regulation MYO10 EPHB2 23986484 1487092 Positive_regulation MYO10 EPHB2 23986484 1487093 Positive_regulation MYO10 EPHB2 24069528 750734 Positive_regulation MYO10 TMOD1 22230661 3084395 Positive_regulation MYO10 TMOD1 22675303 957625 Positive_regulation MYO16 CAPN8 24489676 2915639 Positive_regulation MYO16 CAPN8 24489676 2915847 Positive_regulation MYO16 EPHB2 10648571 1255616 Positive_regulation MYO16 EPHB2 18793427 281699 Positive_regulation MYO16 EPHB2 23986484 1487090 Positive_regulation MYO16 EPHB2 23986484 1487091 Positive_regulation MYO16 EPHB2 24069528 750726 Positive_regulation MYO16 TMOD1 22230661 3084392 Positive_regulation MYO16 TMOD1 22675303 957622 Positive_regulation MYO19 CAPN8 24489676 2915625 Positive_regulation MYO19 CAPN8 24489676 2915833 Positive_regulation MYO19 EPHB2 10648571 1255615 Positive_regulation MYO19 EPHB2 18793427 281698 Positive_regulation MYO19 EPHB2 23986484 1487088 Positive_regulation MYO19 EPHB2 23986484 1487089 Positive_regulation MYO19 EPHB2 24069528 750724 Positive_regulation MYO19 TMOD1 22230661 3084385 Positive_regulation MYO19 TMOD1 22675303 957615 Positive_regulation MYO6 CAPN8 24489676 2915667 Positive_regulation MYO6 CAPN8 24489676 2915875 Positive_regulation MYO6 EPHB2 10648571 1255619 Positive_regulation MYO6 EPHB2 18793427 281701 Positive_regulation MYO6 EPHB2 23986484 1487094 Positive_regulation MYO6 EPHB2 23986484 1487095 Positive_regulation MYO6 EPHB2 24069528 750736 Positive_regulation MYO6 TMOD1 22230661 3084398 Positive_regulation MYO6 TMOD1 22675303 957628 Positive_regulation MYOC GPR115 24367514 2900042 Positive_regulation MYOC GPR132 24367514 2900031 Positive_regulation MYOC GPR87 24367514 2900111 Positive_regulation MYOCD EPHB2 20446923 651372 Positive_regulation MYOCD EPHB2 20446923 651374 Positive_regulation MYOCD EPHB2 20446923 651376 Positive_regulation MYOCD EPHB2 23855625 1232434 Positive_regulation MYOCD EPHB2 23855625 1232435 Positive_regulation MYOCD EPHB2 23855625 1232463 Positive_regulation MYOCD FOXO1 23554919 2773872 Positive_regulation MYOG EPHB2 21048967 2480250 Positive_regulation MYOG FOXO1 23799156 2807596 Positive_regulation MYOG PGC 25375380 579004 Positive_regulation MYOG WNT7A 23497616 3161796 Positive_regulation NA GLP1R 25278825 939099 Positive_regulation NA TNF 18986521 1625137 Positive_regulation NAA10 HBEGF 24390343 1991248 Positive_regulation NAA11 HBEGF 24390343 1991256 Positive_regulation NAA15 HBEGF 24390343 1991258 Positive_regulation NAA16 HBEGF 24390343 1991255 Positive_regulation NAA20 HBEGF 24390343 1991247 Positive_regulation NAA25 HBEGF 24390343 1991252 Positive_regulation NAA30 HBEGF 24390343 1991249 Positive_regulation NAA35 HBEGF 24390343 1991251 Positive_regulation NAA38 HBEGF 24390343 1991250 Positive_regulation NAA40 HBEGF 24390343 1991253 Positive_regulation NAA50 HBEGF 24390343 1991257 Positive_regulation NAA60 HBEGF 24390343 1991254 Positive_regulation NAA60 PLAU 2166055 1387625 Positive_regulation NAALADL1 TNF 16417648 459578 Positive_regulation NAALADL1 TNF 22206014 2584273 Positive_regulation NAB1 DAPK1 22160140 2170574 Positive_regulation NAB1 DAPK1 22160140 2170575 Positive_regulation NAB1 DAPK1 22160140 2170586 Positive_regulation NAB2 DAPK1 22160140 2170576 Positive_regulation NAB2 DAPK1 22160140 2170577 Positive_regulation NAB2 DAPK1 22160140 2170587 Positive_regulation NAB2 MAP2K6 19390590 2414869 Positive_regulation NACC1 EPHB2 16512905 383197 Positive_regulation NACC2 EPHB2 16512905 383198 Positive_regulation NAMPT FOXO1 24905194 2977202 Positive_regulation NAMPT GLP1R 22950055 730416 Positive_regulation NAMPT IL1B 23198120 1615784 Positive_regulation NAMPT MUC16 24885580 1233676 Positive_regulation NAMPT MUC16 24885580 1233786 Positive_regulation NAMPT MUC16 24885580 1234036 Positive_regulation NAMPT TNF 18714344 2395665 Positive_regulation NAMPT TNF 20847813 1747867 Positive_regulation NAMPT TNF 21542902 1229076 Positive_regulation NAMPT TNF 21542902 1229077 Positive_regulation NAMPT TNF 21542902 1229078 Positive_regulation NAMPT TNF 21542902 1229081 Positive_regulation NAMPT TNF 21542902 1229083 Positive_regulation NAMPT TNF 22910888 1750238 Positive_regulation NAMPT TNF 23198120 1615783 Positive_regulation NAMPT TNF 23229270 1734766 Positive_regulation NAMPT TNF 23634778 809389 Positive_regulation NAMPT TNF 24891763 1759431 Positive_regulation NANOG ABCG2 19107196 2402694 Positive_regulation NANOG ABCG2 19107196 2402695 Positive_regulation NANOG ABCG2 19107196 2402696 Positive_regulation NANOG ABCG2 19107196 2402697 Positive_regulation NANOG ABCG2 19107196 2402699 Positive_regulation NANOG EPHB2 21194951 665998 Positive_regulation NANOG FAS 22916262 2680595 Positive_regulation NANOG FOXO1 25369332 3022706 Positive_regulation NANOG HBEGF 22873932 533015 Positive_regulation NANOG TNF 24580841 3169886 Positive_regulation NANOG TNF 24580841 3169895 Positive_regulation NANOG ZFP57 21915945 3171625 Positive_regulation NANOG ZFP57 21915945 3171643 Positive_regulation NANOG ZFP57 21915945 3171661 Positive_regulation NANOG ZFP57 21915945 3171688 Positive_regulation NANOG ZFP57 24550733 2356265 Positive_regulation NANOG ZFP57 24550733 2356411 Positive_regulation NANOG ZFP57 24550733 2356631 Positive_regulation NANOG ZFP57 24550733 2356778 Positive_regulation NANOS2 TLR7 19139169 1553589 Positive_regulation NANOS2 TLR7 22312110 1567163 Positive_regulation NANOS2 TNF 11390433 1519461 Positive_regulation NANOS2 TNF 22545173 2371263 Positive_regulation NANOS2 TNF 22811738 636691 Positive_regulation NANOS2 TNF 22811738 636693 Positive_regulation NANOS3 ARSA 24376548 2901181 Positive_regulation NAPEPLD ARSA 22662201 2647282 Positive_regulation NAV1 FOXO1 22400069 2608771 Positive_regulation NAV1 FOXO1 22400069 2608776 Positive_regulation NAV1 FOXO1 22400069 2608777 Positive_regulation NAV1 FOXO1 22400069 2608785 Positive_regulation NBL1 TNF 7520469 1589451 Positive_regulation NBN EPHB2 21208456 1228798 Positive_regulation NCAM1 EPHB2 25110505 3085917 Positive_regulation NCAM2 EPHB2 25110505 3085921 Positive_regulation NCAPD3 TMPRSS4 24934155 1419792 Positive_regulation NCAPD3 TMPRSS4 24934155 1419818 Positive_regulation NCAPG2 TMPRSS4 24934155 1419784 Positive_regulation NCAPG2 TMPRSS4 24934155 1419816 Positive_regulation NCAPH2 TMPRSS4 24934155 1419788 Positive_regulation NCAPH2 TMPRSS4 24934155 1419817 Positive_regulation NCBP1 RNASE1 23826386 2812448 Positive_regulation NCBP2 RNASE1 23826386 2812449 Positive_regulation NCEH1 PGC 25610371 872914 Positive_regulation NCF1 PTGER2 17204153 1655035 Positive_regulation NCF1 TNF 16043520 1536944 Positive_regulation NCF1 TNF 21167936 857661 Positive_regulation NCF1 TNF 23434665 1102021 Positive_regulation NCF1 TNF 23671702 2792519 Positive_regulation NCF1 TNF 23671702 2792524 Positive_regulation NCF1 TNF 24212830 499066 Positive_regulation NCF2 PTGER2 17204153 1655036 Positive_regulation NCOA1 PGC 17389765 3071454 Positive_regulation NCOA3 EPHB2 21572418 1925869 Positive_regulation NCOA3 EPHB2 21860657 813148 Positive_regulation NCOA3 EPHB2 23388133 267762 Positive_regulation NCOA3 MATN2 24691449 2947770 Positive_regulation NCOA3 TNF 24918060 853935 Positive_regulation NCOA3 TNF 24918060 853936 Positive_regulation NCOA3 TNF 24918060 853937 Positive_regulation NCOR1 PGC 23304112 3076128 Positive_regulation NCOR2 PGC 23304112 3076129 Positive_regulation NCR2 TLR7 21151495 2485076 Positive_regulation NCR2 TNF 24744763 912255 Positive_regulation NCR2 TNF 25061260 1760253 Positive_regulation NDE1 NES 15251038 277771 Positive_regulation NDOR1 MMP7 21423441 972130 Positive_regulation NDOR1 TNF 24344780 1667478 Positive_regulation NDOR1 TNF 24966471 1759844 Positive_regulation NDRG1 TLR7 24740015 2953856 Positive_regulation NEB TMOD1 12975349 1297008 Positive_regulation NEB TMOD1 12975349 1297077 Positive_regulation NEB TMOD1 21727195 1389795 Positive_regulation NEB TMOD1 24430868 1820491 Positive_regulation NEB TMOD1 24586196 2357071 Positive_regulation NEB TNNT2 24043862 1610593 Positive_regulation NEDD1 NES 15251038 277805 Positive_regulation NEDD9 ANAPC10 15144564 277500 Positive_regulation NEDD9 ANAPC10 15144564 277501 Positive_regulation NEDD9 APC 15144564 277557 Positive_regulation NEDD9 AURKA 25594051 2173960 Positive_regulation NEDD9 BMP1 24554596 2213061 Positive_regulation NEDD9 BMP10 24554596 2213069 Positive_regulation NEDD9 BMP15 24554596 2213062 Positive_regulation NEDD9 BMP2 24554596 2213063 Positive_regulation NEDD9 BMP3 24554596 2213064 Positive_regulation NEDD9 BMP4 24554596 2213065 Positive_regulation NEDD9 BMP5 24554596 2213066 Positive_regulation NEDD9 BMP6 24554596 2213067 Positive_regulation NEDD9 BMP7 24554596 2213068 Positive_regulation NEDD9 CA2 22621899 1803300 Positive_regulation NEDD9 CALCA 25594051 2173958 Positive_regulation NEDD9 CALM3 22621899 1803301 Positive_regulation NEDD9 CBL 10704446 1256278 Positive_regulation NEDD9 CDH1 15144564 277498 Positive_regulation NEDD9 CDH1 15144564 277499 Positive_regulation NEDD9 CDH1 15144564 277520 Positive_regulation NEDD9 CDH1 15144564 277540 Positive_regulation NEDD9 CDH1 15144564 277555 Positive_regulation NEDD9 CDH1 15144564 277556 Positive_regulation NEDD9 CDH13 23557442 151381 Positive_regulation NEDD9 CHUK 18246321 1644007 Positive_regulation NEDD9 CRKL 10704446 1256279 Positive_regulation NEDD9 FLT3 21552520 2517588 Positive_regulation NEDD9 HSPA9 22022577 2563937 Positive_regulation NEDD9 IKBKB 18246321 1644008 Positive_regulation NEDD9 IKBKG 18246321 1644009 Positive_regulation NEDD9 LTB 7507507 1588848 Positive_regulation NEDD9 MAP3K8 24980047 1576887 Positive_regulation NEDD9 MYH9 22912631 903761 Positive_regulation NEDD9 MYO10 22347397 2595814 Positive_regulation NEDD9 MYO16 22347397 2595813 Positive_regulation NEDD9 MYO19 22347397 2595812 Positive_regulation NEDD9 MYO6 22347397 2595815 Positive_regulation NEDD9 NPY6R 24058594 2848141 Positive_regulation NEDD9 NTRK1 19662191 178014 Positive_regulation NEDD9 PIK3CA 25400915 1037101 Positive_regulation NEDD9 PIK3R1 25400915 1037102 Positive_regulation NEDD9 PTK2B 25594051 2173914 Positive_regulation NEDD9 RABGEF1 25594051 2173925 Positive_regulation NEDD9 SMAD1 19587023 621070 Positive_regulation NEDD9 SMAD2 19587023 621071 Positive_regulation NEDD9 SMAD3 15144564 277502 Positive_regulation NEDD9 SMAD3 15144564 277503 Positive_regulation NEDD9 SMAD3 15144564 277504 Positive_regulation NEDD9 SMAD3 15144564 277521 Positive_regulation NEDD9 SMAD3 15144564 277522 Positive_regulation NEDD9 SMAD3 15144564 277575 Positive_regulation NEDD9 SMAD3 19587023 621072 Positive_regulation NEDD9 SMAD3 23475109 605821 Positive_regulation NEDD9 SMAD4 19587023 621073 Positive_regulation NEDD9 SMAD5 19587023 621074 Positive_regulation NEDD9 SMAD6 19587023 621075 Positive_regulation NEDD9 SMAD7 19587023 621076 Positive_regulation NEDD9 SMAD9 19587023 621077 Positive_regulation NEDD9 SMURF2 20825672 585599 Positive_regulation NEDD9 SMURF2 20825672 585600 Positive_regulation NEDD9 SMURF2 20825672 585606 Positive_regulation NEDD9 SMURF2 20825672 585615 Positive_regulation NEDD9 SMURF2 20825672 585616 Positive_regulation NEDD9 SMURF2 20825672 585620 Positive_regulation NEDD9 SMURF2 20825672 585625 Positive_regulation NEDD9 SMURF2 20825672 585626 Positive_regulation NEDD9 SRC 20825672 585618 Positive_regulation NEDD9 SRC 22869051 2180504 Positive_regulation NEDD9 SRC 23372733 2745849 Positive_regulation NEDD9 STK11 23668926 625607 Positive_regulation NEDD9 TGFB3 23372733 2745842 Positive_regulation NEDD9 TNIP2 23557442 151382 Positive_regulation NEFH PGC 25610371 872915 Positive_regulation NEFL ANGPT1 22412941 2609863 Positive_regulation NEK2 NES 15251038 277806 Positive_regulation NEK6 CTGF 24763737 2958429 Positive_regulation NELFCD CD14 15975149 3105078 Positive_regulation NELFCD FAS 15154605 629965 Positive_regulation NELFCD FUT4 11535629 1520707 Positive_regulation NELFCD HRH1 20948178 3079142 Positive_regulation NELFCD IFI27 24588000 187348 Positive_regulation NELFCD JAG1 18665263 2394117 Positive_regulation NELFCD JAG1 18665263 2394118 Positive_regulation NELFCD JAG1 23071776 2704163 Positive_regulation NELFCD JAG1 23086448 1958108 Positive_regulation NELFCD MIP 21984926 2561228 Positive_regulation NELFCD NES 19406170 1770206 Positive_regulation NELFCD STAT4 10449525 1512283 Positive_regulation NELFCD STAT4 15899058 103816 Positive_regulation NELFCD STAT4 16606674 1540073 Positive_regulation NELFCD STAT4 19808254 1556472 Positive_regulation NELFCD STAT4 22566904 899792 Positive_regulation NELFCD STAT4 23990947 2840500 Positive_regulation NELFCD STAT4 24058798 1706005 Positive_regulation NELFCD STAT4 24062747 909019 Positive_regulation NELFCD STAT4 24188121 1728384 Positive_regulation NELFCD STAT4 25309545 914596 Positive_regulation NELFCD TLR7 16365150 1539019 Positive_regulation NELFCD TLR7 17254349 1695635 Positive_regulation NELFCD TLR7 19635859 1555446 Positive_regulation NELFCD TLR7 19749770 1921391 Positive_regulation NELFCD TLR7 20847936 1747904 Positive_regulation NELFCD TLR7 21253574 3050419 Positive_regulation NELFCD TLR7 21364926 2504470 Positive_regulation NELFCD TLR7 21494377 1037999 Positive_regulation NELFCD TLR7 21750585 1918468 Positive_regulation NELFCD TLR7 22206014 2584253 Positive_regulation NELFCD TLR7 22322306 834303 Positive_regulation NELFCD TLR7 22927956 2681206 Positive_regulation NELFCD TLR7 22973560 863677 Positive_regulation NELFCD TLR7 23028609 2691855 Positive_regulation NELFCD TLR7 23197922 88260 Positive_regulation NELFCD TLR7 23271916 1162552 Positive_regulation NELFCD TLR7 23700434 2796196 Positive_regulation NELFCD TLR7 23935651 638098 Positive_regulation NELFCD TLR7 24740301 2954612 Positive_regulation NELFCD TNF 12486099 1525578 Positive_regulation NELFCD TNF 19672468 1670835 Positive_regulation NELFCD TNF 20046843 1670863 Positive_regulation NELFCD TNF 20127485 3157935 Positive_regulation NELFCD TNF 20836885 1620526 Positive_regulation NELFCD TNF 22002242 488152 Positive_regulation NELFCD TNF 22470449 2614197 Positive_regulation NELFCD TNF 22876751 3210464 Positive_regulation NELFCD TNF 23006537 1024587 Positive_regulation NELFCD TNF 23239994 2727150 Positive_regulation NELFCD TNF 23844018 2819016 Positive_regulation NELFCD TNF 24465826 2911828 Positive_regulation NELFCD TNF 24637903 2934973 Positive_regulation NELFCD TNF 25177159 1716705 Positive_regulation NELFCD TNF 25309773 1083066 Positive_regulation NELFCD TNF PMC3920362 3102776 Positive_regulation NELFCD TNF PMC4052542 2247004 Positive_regulation NELFCD TP63 10993913 1517176 Positive_regulation NELL2 EPHB2 24465772 2911744 Positive_regulation NES ANXA6 25133189 196815 Positive_regulation NES APC 24373095 1482308 Positive_regulation NES ARID4B 24552625 2013157 Positive_regulation NES BAG6 22558287 2625009 Positive_regulation NES BARD1 22737296 656941 Positive_regulation NES BMI1 22275880 929014 Positive_regulation NES BRCA1 22737296 656940 Positive_regulation NES BRCA2 24013206 1982208 Positive_regulation NES CA2 25379789 3023869 Positive_regulation NES CADM1 7593171 1437452 Positive_regulation NES CADM2 7593171 1437450 Positive_regulation NES CADM3 7593171 1437449 Positive_regulation NES CADM4 7593171 1437451 Positive_regulation NES CCNB1 22685408 3057050 Positive_regulation NES CD40LG 18053121 384483 Positive_regulation NES CDC25B 25059436 308267 Positive_regulation NES CDCA2 23509715 179998 Positive_regulation NES CDCA3 23509715 179999 Positive_regulation NES CDCA4 23509715 180000 Positive_regulation NES CDCA5 23509715 180001 Positive_regulation NES CDCA7 23509715 180002 Positive_regulation NES CDCA8 23509715 180003 Positive_regulation NES CDK5 20200223 1774889 Positive_regulation NES CDK5 20200223 1774891 Positive_regulation NES CDK5 20200223 1774893 Positive_regulation NES CDK5 21346193 1788643 Positive_regulation NES CDK5 21902831 3160713 Positive_regulation NES CPEB1 25216517 2199695 Positive_regulation NES EGF 21203407 1912573 Positive_regulation NES EGF 23468987 2760616 Positive_regulation NES EIF5A 11238447 1267494 Positive_regulation NES EIF5A 11238447 1267501 Positive_regulation NES EIF5A 11238447 1267510 Positive_regulation NES EIF5A 11238447 1267514 Positive_regulation NES EIF5A 11238447 1267517 Positive_regulation NES EIF5A 11238447 1267526 Positive_regulation NES ENG 24073285 2853658 Positive_regulation NES F12 24265548 1916496 Positive_regulation NES FGF2 21909360 2550640 Positive_regulation NES FGF2 24294177 3092489 Positive_regulation NES FGF2 24572070 3169864 Positive_regulation NES FGFR3 21278733 1966536 Positive_regulation NES GEN1 25209024 1945971 Positive_regulation NES GFAP 21304179 2174844 Positive_regulation NES GFAP 22216399 1717123 Positive_regulation NES GFAP 23869260 86008 Positive_regulation NES GFAP 23869260 86009 Positive_regulation NES GFAP 24373095 1482307 Positive_regulation NES HDAC1 24552625 2013160 Positive_regulation NES HDAC2 24552625 2013161 Positive_regulation NES HGF 24572070 3169858 Positive_regulation NES IL12A 25133189 196816 Positive_regulation NES IL12B 25133189 196817 Positive_regulation NES INHBA 22132182 2574316 Positive_regulation NES IPO7 24490135 853678 Positive_regulation NES JUN 24349499 2898366 Positive_regulation NES KMT2A 24172249 522285 Positive_regulation NES METAP2 20634564 27549 Positive_regulation NES MME 1993730 1369213 Positive_regulation NES MME 23236273 3060140 Positive_regulation NES MSC 24572070 3169854 Positive_regulation NES MYC 21304179 2174834 Positive_regulation NES MYC 23591719 3135418 Positive_regulation NES MYLIP 23016664 387851 Positive_regulation NES NOTCH1 21342503 259244 Positive_regulation NES NOTCH1 24931375 851277 Positive_regulation NES NOTCH2 21342503 259245 Positive_regulation NES NOTCH2 24931375 851278 Positive_regulation NES NOTCH3 21342503 259246 Positive_regulation NES NOTCH3 24931375 851279 Positive_regulation NES NOTCH4 21342503 259247 Positive_regulation NES NOTCH4 24931375 851280 Positive_regulation NES NR0B1 24013206 1982209 Positive_regulation NES NRG1 23938193 510177 Positive_regulation NES NRG2 23938193 510178 Positive_regulation NES NRG3 23938193 510179 Positive_regulation NES NRG4 23938193 510176 Positive_regulation NES RAN 11149926 1267017 Positive_regulation NES RAN 11149926 1267019 Positive_regulation NES RAN 11149926 1267027 Positive_regulation NES RAN 11149926 1267028 Positive_regulation NES RAN 11149926 1267029 Positive_regulation NES RAN 11149926 1267031 Positive_regulation NES RAN 11149927 1267079 Positive_regulation NES RAN 11238447 1267527 Positive_regulation NES RAN 11425870 1271828 Positive_regulation NES RAN 21708948 1192328 Positive_regulation NES RANBP1 8794858 1455934 Positive_regulation NES RANBP3 11425870 1271832 Positive_regulation NES RANBP3 20375145 1775633 Positive_regulation NES RBBP4 24552625 2013162 Positive_regulation NES RBBP7 24552625 2013163 Positive_regulation NES ROCK1 24404335 206105 Positive_regulation NES ROCK2 24404335 206106 Positive_regulation NES RPS19 20463883 2314116 Positive_regulation NES SAP130 24552625 2013159 Positive_regulation NES SAP30 24552625 2013156 Positive_regulation NES SATB1 23762260 2802660 Positive_regulation NES SETD2 25088159 412636 Positive_regulation NES SETD2 25088159 412638 Positive_regulation NES SETD2 25088159 412642 Positive_regulation NES SIN3A 24552625 2013158 Positive_regulation NES SKP1 23226372 2724388 Positive_regulation NES SKP2 23226372 2724389 Positive_regulation NES SMAD3 24718260 2950600 Positive_regulation NES SMAD4 24625091 272310 Positive_regulation NES SMAD4 24625091 272355 Positive_regulation NES SOX12 20463883 2314117 Positive_regulation NES SOX6 24066135 2851213 Positive_regulation NES TNPO1 24586428 2924650 Positive_regulation NES TNPO2 24586428 2924649 Positive_regulation NES TNPO3 24586428 2924648 Positive_regulation NES TP53 23825024 1816861 Positive_regulation NES TREH 25003205 2986945 Positive_regulation NES TREH 25003205 2986947 Positive_regulation NES UMOD 25371902 201488 Positive_regulation NES UMOD 25371902 201489 Positive_regulation NES UMOD 25371902 201490 Positive_regulation NES VEGFA 25088159 412637 Positive_regulation NES VEGFA 25206911 2006349 Positive_regulation NES WNT11 20219091 1853705 Positive_regulation NES WNT3A 22132182 2574315 Positive_regulation NES WT1 20066433 2242866 Positive_regulation NES XPO1 11238447 1267503 Positive_regulation NES XPO1 12045187 1283698 Positive_regulation NES XPO1 12045187 1283700 Positive_regulation NES XPO1 15472721 173321 Positive_regulation NES XPO1 17067381 3116364 Positive_regulation NES XPO1 17726514 2377631 Positive_regulation NES XPO1 17726514 2377633 Positive_regulation NES XPO1 17726514 2377634 Positive_regulation NES XPO1 18641393 1164110 Positive_regulation NES XPO1 19139260 1363197 Positive_regulation NES XPO1 19564402 1367414 Positive_regulation NES XPO1 19606211 2421544 Positive_regulation NES XPO1 19606211 2421546 Positive_regulation NES XPO1 19606211 2421551 Positive_regulation NES XPO1 19750013 2426366 Positive_regulation NES XPO1 19750013 2426368 Positive_regulation NES XPO1 20352102 2444800 Positive_regulation NES XPO1 20465818 585449 Positive_regulation NES XPO1 20465818 585485 Positive_regulation NES XPO1 21034499 1026044 Positive_regulation NES XPO1 21092276 258054 Positive_regulation NES XPO1 21109527 2059052 Positive_regulation NES XPO1 21268017 808244 Positive_regulation NES XPO1 21695276 2530339 Positive_regulation NES XPO1 21811608 2539704 Positive_regulation NES XPO1 21811608 2539710 Positive_regulation NES XPO1 21871131 1863056 Positive_regulation NES XPO1 22334672 1201174 Positive_regulation NES XPO1 22334672 1201186 Positive_regulation NES XPO1 22815488 1204063 Positive_regulation NES XPO1 22815488 1204065 Positive_regulation NES XPO1 22815488 1204067 Positive_regulation NES XPO1 22815488 1204069 Positive_regulation NES XPO1 22992334 533092 Positive_regulation NES XPO1 22992334 533093 Positive_regulation NES XPO1 22992334 533095 Positive_regulation NES XPO1 22992334 533099 Positive_regulation NES XPO1 23150790 3131637 Positive_regulation NES XPO1 23181164 654372 Positive_regulation NES XPO1 23297360 1033874 Positive_regulation NES XPO1 23297360 1033887 Positive_regulation NES XPO1 23297360 1033888 Positive_regulation NES XPO1 23383123 2748038 Positive_regulation NES XPO1 23406872 1033930 Positive_regulation NES XPO1 23951221 2833817 Positive_regulation NES XPO1 23951221 2833818 Positive_regulation NES XPO1 23951221 2833828 Positive_regulation NES XPO1 23951221 2833839 Positive_regulation NES XPO1 23951221 2833841 Positive_regulation NES XPO1 23965528 3223459 Positive_regulation NES XPO1 23984714 3215878 Positive_regulation NES XPO1 23984714 3215879 Positive_regulation NES XPO1 24478458 1820801 Positive_regulation NES XPO1 24959884 2983262 Positive_regulation NES XPO1 25072814 2993037 Positive_regulation NES XPO1 25233087 2301440 Positive_regulation NES XPO4 21109527 2059055 Positive_regulation NES XPO4 24959884 2983265 Positive_regulation NES XPO5 21109527 2059054 Positive_regulation NES XPO5 24959884 2983264 Positive_regulation NES XPO6 21109527 2059056 Positive_regulation NES XPO6 24959884 2983266 Positive_regulation NES XPO7 21109527 2059053 Positive_regulation NES XPO7 24959884 2983263 Positive_regulation NET1 TNF 16552434 427285 Positive_regulation NEU1 TLR7 25187624 761275 Positive_regulation NEU1 TLR7 25187624 761500 Positive_regulation NEUROD1 CCND1 25505873 872607 Positive_regulation NEUROD1 EFNB1 22661924 937348 Positive_regulation NEUROD1 EFNB1 23346046 866548 Positive_regulation NEUROD1 EPHB2 17224080 1645046 Positive_regulation NEUROD1 EPHB2 19502418 708725 Positive_regulation NEUROD1 EPHB2 21203386 2489649 Positive_regulation NEUROD1 EPHB2 22812497 292277 Positive_regulation NEUROD1 EPHB2 23342124 2742506 Positive_regulation NEUROD1 EPHB2 23346046 866551 Positive_regulation NEUROD1 EPHB2 24744103 494795 Positive_regulation NEUROD1 HRH1 23497494 1998365 Positive_regulation NEUROD1 IFI27 21566658 547264 Positive_regulation NEUROD1 IFI27 24779367 1483247 Positive_regulation NEUROD1 IL1B 24891958 2003461 Positive_regulation NEUROD1 LBP 22523540 2620152 Positive_regulation NEUROD1 MAP2K6 21203386 2489655 Positive_regulation NEUROD1 NEDD9 25594051 2173926 Positive_regulation NEUROD1 NGFR 22891073 882643 Positive_regulation NEUROD1 NR2F1 22289655 1997549 Positive_regulation NEUROD1 NR2F1 23472160 2764305 Positive_regulation NEUROD1 TMOD1 23638401 2236518 Positive_regulation NEUROD2 CCND1 25505873 872609 Positive_regulation NEUROD2 EFNB1 22661924 937349 Positive_regulation NEUROD2 EFNB1 23346046 866552 Positive_regulation NEUROD2 EPHB2 17224080 1645047 Positive_regulation NEUROD2 EPHB2 21203386 2489657 Positive_regulation NEUROD2 EPHB2 22812497 292279 Positive_regulation NEUROD2 EPHB2 23342124 2742509 Positive_regulation NEUROD2 EPHB2 23346046 866555 Positive_regulation NEUROD2 EPHB2 24744103 494796 Positive_regulation NEUROD2 HRH1 23497494 1998366 Positive_regulation NEUROD2 IFI27 21566658 547265 Positive_regulation NEUROD2 IFI27 24779367 1483248 Positive_regulation NEUROD2 IL1B 24891958 2003463 Positive_regulation NEUROD2 LBP 22523540 2620153 Positive_regulation NEUROD2 MAP2K6 21203386 2489663 Positive_regulation NEUROD2 NEDD9 25594051 2173927 Positive_regulation NEUROD2 NGFR 22891073 882646 Positive_regulation NEUROD2 NR2F1 22289655 1997551 Positive_regulation NEUROD2 NR2F1 23472160 2764306 Positive_regulation NEUROD2 TMOD1 23638401 2236520 Positive_regulation NEUROD4 CCND1 25505873 872603 Positive_regulation NEUROD4 EFNB1 22661924 937344 Positive_regulation NEUROD4 EFNB1 23346046 866540 Positive_regulation NEUROD4 EPHB2 17224080 1645043 Positive_regulation NEUROD4 EPHB2 21203386 2489630 Positive_regulation NEUROD4 EPHB2 22812497 292273 Positive_regulation NEUROD4 EPHB2 23342124 2742500 Positive_regulation NEUROD4 EPHB2 23346046 866543 Positive_regulation NEUROD4 EPHB2 24744103 494766 Positive_regulation NEUROD4 HRH1 23497494 1998363 Positive_regulation NEUROD4 IFI27 21566658 547261 Positive_regulation NEUROD4 IFI27 24779367 1483245 Positive_regulation NEUROD4 IL1B 24891958 2003457 Positive_regulation NEUROD4 LBP 22523540 2620150 Positive_regulation NEUROD4 MAP2K6 21203386 2489636 Positive_regulation NEUROD4 NEDD9 25594051 2173920 Positive_regulation NEUROD4 NGFR 22891073 882637 Positive_regulation NEUROD4 NR2F1 22289655 1997545 Positive_regulation NEUROD4 NR2F1 23472160 2764303 Positive_regulation NEUROD4 TMOD1 23638401 2236514 Positive_regulation NEUROD6 CCND1 25505873 872605 Positive_regulation NEUROD6 EFNB1 22661924 937345 Positive_regulation NEUROD6 EFNB1 23346046 866544 Positive_regulation NEUROD6 EPHB2 17224080 1645044 Positive_regulation NEUROD6 EPHB2 21203386 2489638 Positive_regulation NEUROD6 EPHB2 22812497 292275 Positive_regulation NEUROD6 EPHB2 23342124 2742503 Positive_regulation NEUROD6 EPHB2 23346046 866547 Positive_regulation NEUROD6 EPHB2 24744103 494767 Positive_regulation NEUROD6 HRH1 23497494 1998364 Positive_regulation NEUROD6 IFI27 21566658 547262 Positive_regulation NEUROD6 IFI27 24779367 1483246 Positive_regulation NEUROD6 IL1B 24891958 2003459 Positive_regulation NEUROD6 LBP 22523540 2620151 Positive_regulation NEUROD6 MAP2K6 21203386 2489644 Positive_regulation NEUROD6 NEDD9 25594051 2173921 Positive_regulation NEUROD6 NGFR 22891073 882640 Positive_regulation NEUROD6 NR2F1 22289655 1997547 Positive_regulation NEUROD6 NR2F1 23472160 2764304 Positive_regulation NEUROD6 TMOD1 23638401 2236516 Positive_regulation NEUROG2 FOXA1 21698206 2530781 Positive_regulation NEUROG2 MSX1 18826576 1832828 Positive_regulation NEUROG3 CPA4 24843545 1493528 Positive_regulation NEUROG3 NES 23383123 2748040 Positive_regulation NFASC ANK3 23530049 1206711 Positive_regulation NFASC ANK3 9744885 1470802 Positive_regulation NFASC F11 9722619 1470642 Positive_regulation NFASC FGF2 9151675 1459991 Positive_regulation NFASC GLDN 17485493 1340213 Positive_regulation NFASC NGF 9151675 1459992 Positive_regulation NFASC NGF 9151675 1460000 Positive_regulation NFAT5 EPHB2 25152734 965841 Positive_regulation NFAT5 EPHB2 25152734 965843 Positive_regulation NFAT5 TLR7 22312110 1567177 Positive_regulation NFAT5 TLR7 23867654 839140 Positive_regulation NFAT5 TLR7 23867654 839141 Positive_regulation NFAT5 TLR7 23867654 839168 Positive_regulation NFAT5 TNF 23867654 839196 Positive_regulation NFATC1 CCL17 20174570 2313075 Positive_regulation NFATC1 EFNB1 22403721 2609229 Positive_regulation NFATC1 EPHB2 23365596 817169 Positive_regulation NFATC1 EPHB2 24444335 295679 Positive_regulation NFATC1 FHL1 19075112 1362571 Positive_regulation NFATC1 FHL1 19075112 1362575 Positive_regulation NFATC1 FHL1 19075112 1362578 Positive_regulation NFATC1 FHL1 PMC2600732 1477208 Positive_regulation NFATC1 MIP 22792407 2663633 Positive_regulation NFATC1 TLR7 21861861 123732 Positive_regulation NFATC1 TNF 18060870 144932 Positive_regulation NFATC1 TNF 20482767 118984 Positive_regulation NFATC1 TNF 22249448 1566853 Positive_regulation NFATC1 TNFSF10 22719861 2653292 Positive_regulation NFATC1 TNFSF10 22719861 2653303 Positive_regulation NFATC1 TNFSF10 22719861 2653304 Positive_regulation NFATC1 TNFSF10 22719861 2653305 Positive_regulation NFATC1 TNFSF10 22719861 2653336 Positive_regulation NFATC1 TNFSF10 22719861 2653340 Positive_regulation NFATC2 MMP7 23762456 2803610 Positive_regulation NFATC2 TNF 22844476 2668262 Positive_regulation NFATC2 TNFSF10 25299780 578218 Positive_regulation NFATC3 EPHB2 22298426 1799996 Positive_regulation NFATC3 EPHB2 22298426 1800006 Positive_regulation NFATC3 RCAN1 22397398 1661323 Positive_regulation NFATC3 TNF 23690827 637407 Positive_regulation NFE2L2 EPHB2 21931870 2555201 Positive_regulation NFE2L2 EPHB2 22701758 2224467 Positive_regulation NFE2L2 EPHB2 23738323 181944 Positive_regulation NFE2L2 EPHB2 25007817 1128328 Positive_regulation NFE2L2 EPHB2 25007817 1128334 Positive_regulation NFE2L2 EPHB2 25210464 2123270 Positive_regulation NFE2L2 EPHB2 25337552 1241333 Positive_regulation NFE2L2 F2R 22541814 125636 Positive_regulation NFE2L2 LBP 25045414 2229606 Positive_regulation NFE2L2 LBP 25045414 2229614 Positive_regulation NFE2L2 LBP 25045414 2229626 Positive_regulation NFE2L2 LBP 25045414 2229627 Positive_regulation NFE2L2 LBP 25045414 2229631 Positive_regulation NFE2L2 PGC 23431256 3154087 Positive_regulation NFE2L2 PGC 24077237 2118266 Positive_regulation NFE2L2 PGC 24288584 2227536 Positive_regulation NFIB IL1R2 18005427 1890969 Positive_regulation NFIB IL1R2 19415126 669067 Positive_regulation NFIX SORL1 16930450 1890513 Positive_regulation NFKB1 CD14 23342367 3222078 Positive_regulation NFKB1 EPHB2 22876248 903053 Positive_regulation NFKB1 EPHB2 23555655 2774716 Positive_regulation NFKB1 EPHB2 24453421 1756774 Positive_regulation NFKB1 FAS 25392688 490138 Positive_regulation NFKB1 ID1 23714001 1699834 Positive_regulation NFKB1 IL1B 12745547 1738450 Positive_regulation NFKB1 IL1B 12745547 1738451 Positive_regulation NFKB1 IL1B 12745547 1738452 Positive_regulation NFKB1 IL1B 12745547 1738453 Positive_regulation NFKB1 IL1B 12745547 1738454 Positive_regulation NFKB1 IL1B 12745547 1738455 Positive_regulation NFKB1 IL1B 12745547 1738456 Positive_regulation NFKB1 IL1B 12745547 1738457 Positive_regulation NFKB1 IL1B 12745547 1738458 Positive_regulation NFKB1 IL1B 12745547 1738459 Positive_regulation NFKB1 IL1B 12745547 1738478 Positive_regulation NFKB1 IL1B 12745547 1738479 Positive_regulation NFKB1 IL1B 15203568 1739689 Positive_regulation NFKB1 IL1B 18472873 1742428 Positive_regulation NFKB1 IL1B 20426870 3098282 Positive_regulation NFKB1 IL1B 21206541 3175182 Positive_regulation NFKB1 IL1B 25436109 1161836 Positive_regulation NFKB1 ITGB2 22110533 633560 Positive_regulation NFKB1 MAP2K6 16491824 1710984 Positive_regulation NFKB1 MAP2K6 23675062 1064442 Positive_regulation NFKB1 MAP2K6 23675062 1064443 Positive_regulation NFKB1 MIP 9788893 798125 Positive_regulation NFKB1 MMP28 15770046 1739888 Positive_regulation NFKB1 MMP28 22570691 2631250 Positive_regulation NFKB1 MMP7 15770046 1739903 Positive_regulation NFKB1 MMP7 22570691 2631265 Positive_regulation NFKB1 SPHK1 20634980 2455691 Positive_regulation NFKB1 SPHK1 20634980 2455768 Positive_regulation NFKB1 SPHK1 20634980 2455786 Positive_regulation NFKB1 STAT4 22969750 877121 Positive_regulation NFKB1 TLR7 17534423 2376178 Positive_regulation NFKB1 TLR7 19966777 1960888 Positive_regulation NFKB1 TLR7 20230632 3213071 Positive_regulation NFKB1 TLR7 20230632 3213104 Positive_regulation NFKB1 TLR7 21750679 2325146 Positive_regulation NFKB1 TLR7 22052242 984355 Positive_regulation NFKB1 TLR7 22242189 2587409 Positive_regulation NFKB1 TLR7 23024779 2689783 Positive_regulation NFKB1 TLR7 23305364 694060 Positive_regulation NFKB1 TLR7 23521892 3215398 Positive_regulation NFKB1 TLR7 24454965 2910514 Positive_regulation NFKB1 TLR7 25117662 2996788 Positive_regulation NFKB1 TLR7 25117662 2996912 Positive_regulation NFKB1 TLR7 25429285 881397 Positive_regulation NFKB1 TLR7 PMC2756345 495805 Positive_regulation NFKB1 TLR7 PMC3953183 2236288 Positive_regulation NFKB1 TM4SF19 25344917 2206204 Positive_regulation NFKB1 TNF 10704075 1736861 Positive_regulation NFKB1 TNF 11097206 702061 Positive_regulation NFKB1 TNF 12003644 312737 Positive_regulation NFKB1 TNF 12003644 312742 Positive_regulation NFKB1 TNF 12745546 1738356 Positive_regulation NFKB1 TNF 1314883 1528384 Positive_regulation NFKB1 TNF 1314883 1528388 Positive_regulation NFKB1 TNF 1314883 1528392 Positive_regulation NFKB1 TNF 1314883 1528394 Positive_regulation NFKB1 TNF 15694007 391924 Positive_regulation NFKB1 TNF 15857511 648864 Positive_regulation NFKB1 TNF 16551357 3096206 Positive_regulation NFKB1 TNF 17032459 319205 Positive_regulation NFKB1 TNF 1740663 1545102 Positive_regulation NFKB1 TNF 17480215 1225742 Positive_regulation NFKB1 TNF 17592646 250176 Positive_regulation NFKB1 TNF 18078008 3208461 Positive_regulation NFKB1 TNF 18450815 2034435 Positive_regulation NFKB1 TNF 18472824 1741858 Positive_regulation NFKB1 TNF 18472824 1741866 Positive_regulation NFKB1 TNF 18472873 1742427 Positive_regulation NFKB1 TNF 18553155 3090002 Positive_regulation NFKB1 TNF 19060883 1983090 Positive_regulation NFKB1 TNF 20126546 2439178 Positive_regulation NFKB1 TNF 20145703 1213512 Positive_regulation NFKB1 TNF 20150970 1213782 Positive_regulation NFKB1 TNF 20181085 2236003 Positive_regulation NFKB1 TNF 20300540 1747129 Positive_regulation NFKB1 TNF 20386714 3046570 Positive_regulation NFKB1 TNF 20967264 2478599 Positive_regulation NFKB1 TNF 21108843 3213394 Positive_regulation NFKB1 TNF 21324111 121471 Positive_regulation NFKB1 TNF 21324111 121472 Positive_regulation NFKB1 TNF 21324111 121476 Positive_regulation NFKB1 TNF 21324111 121499 Positive_regulation NFKB1 TNF 21342546 238017 Positive_regulation NFKB1 TNF 21492465 360642 Positive_regulation NFKB1 TNF 21539730 1626369 Positive_regulation NFKB1 TNF 21569464 1697266 Positive_regulation NFKB1 TNF 21622953 2063352 Positive_regulation NFKB1 TNF 21629653 2525308 Positive_regulation NFKB1 TNF 21738489 2325071 Positive_regulation NFKB1 TNF 21799681 812963 Positive_regulation NFKB1 TNF 21808651 633114 Positive_regulation NFKB1 TNF 21810263 1659150 Positive_regulation NFKB1 TNF 21810263 1659161 Positive_regulation NFKB1 TNF 21838863 3214287 Positive_regulation NFKB1 TNF 21853090 2543187 Positive_regulation NFKB1 TNF 21857970 2544487 Positive_regulation NFKB1 TNF 21912646 2552482 Positive_regulation NFKB1 TNF 21912646 2552494 Positive_regulation NFKB1 TNF 21992116 1697919 Positive_regulation NFKB1 TNF 21992116 1697920 Positive_regulation NFKB1 TNF 22046242 2566194 Positive_regulation NFKB1 TNF 22046242 2566198 Positive_regulation NFKB1 TNF 22046242 2566203 Positive_regulation NFKB1 TNF 22052242 984354 Positive_regulation NFKB1 TNF 22096400 1030535 Positive_regulation NFKB1 TNF 22189739 652968 Positive_regulation NFKB1 TNF 22393382 2608051 Positive_regulation NFKB1 TNF 22406746 1962260 Positive_regulation NFKB1 TNF 22472082 1049157 Positive_regulation NFKB1 TNF 22654792 875813 Positive_regulation NFKB1 TNF 22654792 875814 Positive_regulation NFKB1 TNF 22654792 875829 Positive_regulation NFKB1 TNF 22654792 875834 Positive_regulation NFKB1 TNF 22672528 482512 Positive_regulation NFKB1 TNF 22672528 482518 Positive_regulation NFKB1 TNF 22720084 2654435 Positive_regulation NFKB1 TNF 22911724 2675976 Positive_regulation NFKB1 TNF 22911724 2675979 Positive_regulation NFKB1 TNF 22911724 2675982 Positive_regulation NFKB1 TNF 22911724 2675991 Positive_regulation NFKB1 TNF 22970172 2687437 Positive_regulation NFKB1 TNF 22970172 2687443 Positive_regulation NFKB1 TNF 22973447 2688242 Positive_regulation NFKB1 TNF 23109839 1098349 Positive_regulation NFKB1 TNF 23125866 637089 Positive_regulation NFKB1 TNF 23130241 1043815 Positive_regulation NFKB1 TNF 23168575 2235790 Positive_regulation NFKB1 TNF 23272249 2730244 Positive_regulation NFKB1 TNF 23272249 2730246 Positive_regulation NFKB1 TNF 23299785 3222046 Positive_regulation NFKB1 TNF 23300756 2735920 Positive_regulation NFKB1 TNF 23381555 1140573 Positive_regulation NFKB1 TNF 23424624 2755009 Positive_regulation NFKB1 TNF 23576877 1628490 Positive_regulation NFKB1 TNF 23576877 1628494 Positive_regulation NFKB1 TNF 23576877 1628497 Positive_regulation NFKB1 TNF 23576877 1628501 Positive_regulation NFKB1 TNF 23593011 2345141 Positive_regulation NFKB1 TNF 23593011 2345166 Positive_regulation NFKB1 TNF 23593011 2345208 Positive_regulation NFKB1 TNF 23634661 1666611 Positive_regulation NFKB1 TNF 23651618 3085076 Positive_regulation NFKB1 TNF 23762160 820146 Positive_regulation NFKB1 TNF 24083153 1053921 Positive_regulation NFKB1 TNF 24193319 3138596 Positive_regulation NFKB1 TNF 24212623 497849 Positive_regulation NFKB1 TNF 24212647 497902 Positive_regulation NFKB1 TNF 24318359 2186076 Positive_regulation NFKB1 TNF 24330637 1703405 Positive_regulation NFKB1 TNF 24330732 1870536 Positive_regulation NFKB1 TNF 24453421 1756963 Positive_regulation NFKB1 TNF 24580844 411062 Positive_regulation NFKB1 TNF 24587411 2929896 Positive_regulation NFKB1 TNF 24587411 2929899 Positive_regulation NFKB1 TNF 24587411 2929900 Positive_regulation NFKB1 TNF 24596622 206185 Positive_regulation NFKB1 TNF 24611099 2115397 Positive_regulation NFKB1 TNF 24642040 474549 Positive_regulation NFKB1 TNF 24714696 2950158 Positive_regulation NFKB1 TNF 24740421 2954832 Positive_regulation NFKB1 TNF 24822058 1703411 Positive_regulation NFKB1 TNF 24860732 1694780 Positive_regulation NFKB1 TNF 24876878 825965 Positive_regulation NFKB1 TNF 24983623 2985728 Positive_regulation NFKB1 TNF 25015002 357675 Positive_regulation NFKB1 TNF 25152758 826753 Positive_regulation NFKB1 TNF 25152758 826792 Positive_regulation NFKB1 TNF 25202711 1623185 Positive_regulation NFKB1 TNF 25250048 896987 Positive_regulation NFKB1 TNF 25443632 762681 Positive_regulation NFKB1 TNF 25443632 762699 Positive_regulation NFKB1 TNF 25443632 762705 Positive_regulation NFKB1 TNF 25443632 762712 Positive_regulation NFKB1 TNF 25443632 762718 Positive_regulation NFKB1 TNF 7523573 1589601 Positive_regulation NFKB1 TNF 7629516 1591294 Positive_regulation NFKB1 TNF 7931065 1593133 Positive_regulation NFKB1 TNF 8027185 1444188 Positive_regulation NFKB1 TNF 8027185 1444189 Positive_regulation NFKB1 TNF 8386742 1595096 Positive_regulation NFKB1 TNF 8647884 1451556 Positive_regulation NFKB1 TNF 8647884 1451563 Positive_regulation NFKB1 TNF 8647884 1451597 Positive_regulation NFKB1 TNF 8647884 1451602 Positive_regulation NFKB1 TNF 8655581 1451871 Positive_regulation NFKB1 TNF 8655581 1451904 Positive_regulation NFKB1 TNF 8666909 1597106 Positive_regulation NFKB1 TNF 8691131 1598161 Positive_regulation NFKB1 TNF 8691131 1598162 Positive_regulation NFKB1 TNF 8691131 1598216 Positive_regulation NFKB1 TNF 8691131 1598227 Positive_regulation NFKB1 TNF 8691131 1598228 Positive_regulation NFKB1 TNF 8698809 1452456 Positive_regulation NFKB1 TNF 8698809 1452476 Positive_regulation NFKB1 TNF 8698809 1452477 Positive_regulation NFKB1 TNF 8698809 1452478 Positive_regulation NFKB1 TNF 8760826 1598984 Positive_regulation NFKB1 TNF 8894979 1612766 Positive_regulation NFKB1 TNF 9400742 797549 Positive_regulation NFKB1 TNF PMC2364207 449970 Positive_regulation NFKB1 TNF PMC2750202 450201 Positive_regulation NFKB1 TNF PMC3332443 134778 Positive_regulation NFKB1 TNF PMC3953183 2236287 Positive_regulation NFKB1 TNF PMC4070603 3206068 Positive_regulation NFKB1 TNF PMC4212306 3206365 Positive_regulation NFKB1 TNFSF10 15916713 248766 Positive_regulation NFKB1 TNFSF10 21756247 3093063 Positive_regulation NFKB1 TNFSF10 22672528 482523 Positive_regulation NFKB1 TNFSF10 24130833 2867296 Positive_regulation NFKB2 TNF 20967264 2478600 Positive_regulation NFKB2 TNF 21738489 2325072 Positive_regulation NFKBIA IL1B 24618842 2933389 Positive_regulation NFKBIA TNF 10496355 415411 Positive_regulation NFKBIA TNF 22654792 875826 Positive_regulation NFKBIA TNF 22911724 2675978 Positive_regulation NFKBIA TNFSF10 24147007 2869141 Positive_regulation NFKBIZ TNF 20374638 328758 Positive_regulation NFKBIZ TNF 20374638 328759 Positive_regulation NFKBIZ TNF 20374638 328789 Positive_regulation NFKBIZ TNF 20374638 328790 Positive_regulation NFYA PADI3 18923650 2397771 Positive_regulation NFYB PADI3 18923650 2397772 Positive_regulation NFYC PADI3 18923650 2397773 Positive_regulation NGF ANGPT1 22409996 124964 Positive_regulation NGF EPHB2 20126402 2438837 Positive_regulation NGF EPHB2 21738764 2533732 Positive_regulation NGF EPHB2 21849472 1793456 Positive_regulation NGF EPHB2 24744103 494889 Positive_regulation NGF EPHB2 25514808 3035005 Positive_regulation NGF FOXO1 12913110 1295249 Positive_regulation NGF FOXO1 12913110 1295250 Positive_regulation NGF FOXO1 12913110 1295275 Positive_regulation NGF FOXO1 12913110 1295279 Positive_regulation NGF MAP2K6 22754300 1095906 Positive_regulation NGF MAP2K6 23822837 294447 Positive_regulation NGF NGFR 1313814 1297485 Positive_regulation NGF NGFR 1315318 1297526 Positive_regulation NGF NGFR 1348250 1297635 Positive_regulation NGF NGFR 1671048 1329987 Positive_regulation NGF NGFR 1717486 1335511 Positive_regulation NGF NGFR 1717492 1335586 Positive_regulation NGF NGFR 1908468 1362822 Positive_regulation NGF NGFR 22891073 882651 Positive_regulation NGF NGFR 23660869 3135738 Positive_regulation NGF NGFR 7540615 1436821 Positive_regulation NGF NGFR 7683690 1438831 Positive_regulation NGF NGFR 8408225 1448311 Positive_regulation NGF NGFR 8468355 1449234 Positive_regulation NGF NGFR 8486743 1449302 Positive_regulation NGF NGFR 8603925 1450919 Positive_regulation NGF NGFR 8707832 1453817 Positive_regulation NGF NT5E 22957106 2686658 Positive_regulation NGF PLAT 21785728 1155331 Positive_regulation NGF RCAN1 23825664 2809928 Positive_regulation NGF RCAN1 23825664 2809936 Positive_regulation NGF SPHK1 10545499 1251530 Positive_regulation NGF TNF 23248582 866401 Positive_regulation NGF TNF 23459929 935218 Positive_regulation NGF TNF 24286133 130367 Positive_regulation NGF TNF 24358337 2899571 Positive_regulation NGF TNF 24386191 2902962 Positive_regulation NGF TNF 24884664 1668098 Positive_regulation NGF TNF 25397406 3027169 Positive_regulation NGF TNF 25397406 3027173 Positive_regulation NGF TNF 8676076 1597883 Positive_regulation NGF TNF 9792334 1763751 Positive_regulation NGF TNF 9792334 1763783 Positive_regulation NGFR BDNF 21966426 2557664 Positive_regulation NGFR CASZ1 21490919 2512579 Positive_regulation NGFR CASZ1 21490919 2512587 Positive_regulation NGFR CASZ1 21490919 2512588 Positive_regulation NGFR CDKN1A 23660869 3135739 Positive_regulation NGFR CNTF 19267906 1655643 Positive_regulation NGFR CNTF 7540616 1436844 Positive_regulation NGFR ECM1 22419851 1914106 Positive_regulation NGFR ECM2 22419851 1914107 Positive_regulation NGFR EEF1A2 23593219 2780360 Positive_regulation NGFR FYN 22880054 2673809 Positive_regulation NGFR HRAS 8045941 1444386 Positive_regulation NGFR IL2RB 21519548 85488 Positive_regulation NGFR KRAS 8045941 1444387 Positive_regulation NGFR MLST8 25221943 3007217 Positive_regulation NGFR MTOR 25221943 3007219 Positive_regulation NGFR NGF 1313814 1297486 Positive_regulation NGFR NGF 1315318 1297527 Positive_regulation NGFR NGF 1348250 1297636 Positive_regulation NGFR NGF 1618900 1324473 Positive_regulation NGFR NGF 1655813 1328405 Positive_regulation NGFR NGF 1671048 1329970 Positive_regulation NGFR NGF 1671048 1329971 Positive_regulation NGFR NGF 1671048 1329972 Positive_regulation NGFR NGF 1671048 1329973 Positive_regulation NGFR NGF 1671048 1329974 Positive_regulation NGFR NGF 1671048 1329975 Positive_regulation NGFR NGF 1671048 1329988 Positive_regulation NGFR NGF 1671048 1329989 Positive_regulation NGFR NGF 1671048 1329990 Positive_regulation NGFR NGF 1671048 1329993 Positive_regulation NGFR NGF 1671048 1329994 Positive_regulation NGFR NGF 1671048 1329995 Positive_regulation NGFR NGF 1717486 1335512 Positive_regulation NGFR NGF 1717492 1335587 Positive_regulation NGFR NGF 1908468 1362823 Positive_regulation NGFR NGF 20680101 1911797 Positive_regulation NGFR NGF 21785728 1155325 Positive_regulation NGFR NGF 25347857 2252405 Positive_regulation NGFR NGF 7540615 1436823 Positive_regulation NGFR NGF 7559764 1437129 Positive_regulation NGFR NGF 7683690 1438832 Positive_regulation NGFR NGF 8408225 1448312 Positive_regulation NGFR NGF 8468355 1449235 Positive_regulation NGFR NGF 8486743 1449304 Positive_regulation NGFR NGF 8603925 1450921 Positive_regulation NGFR NGF 8707832 1453818 Positive_regulation NGFR NRAS 8045941 1444388 Positive_regulation NGFR PIK3CA 22880054 2673810 Positive_regulation NGFR PIK3CA 22880054 2673811 Positive_regulation NGFR PIK3CA 22880054 2674101 Positive_regulation NGFR PIK3R1 22880054 2673812 Positive_regulation NGFR PIK3R1 22880054 2673813 Positive_regulation NGFR PIK3R1 22880054 2674102 Positive_regulation NGFR RAF1 8045941 1444389 Positive_regulation NGFR RPTOR 25221943 3007218 Positive_regulation NGFR SOX10 22492709 2074607 Positive_regulation NGFR SYK 22880054 2673807 Positive_regulation NGFR SYK 22880054 2673808 Positive_regulation NGFR TGFB1 23300742 2735819 Positive_regulation NGFR TGFB2 23300742 2735820 Positive_regulation NGFR TGFB3 23300742 2735821 Positive_regulation NGFR TNFRSF1B 21519548 85487 Positive_regulation NGFR TNFRSF1B 8676061 1597703 Positive_regulation NINL NES 15251038 277793 Positive_regulation NISCH CAPN8 25147502 870876 Positive_regulation NKD1 AXIN2 19888210 1903111 Positive_regulation NKD1 AXIN2 19888210 1903117 Positive_regulation NKRF MIP 23840526 2814929 Positive_regulation NLK TNF 24816797 2963073 Positive_regulation NLN TNF 22046952 3210111 Positive_regulation NLN ZFP57 24846143 2972114 Positive_regulation NLRC4 MIP 25232720 2372942 Positive_regulation NLRC4 TLR7 24827856 2969844 Positive_regulation NLRP12 TNF 24273542 909952 Positive_regulation NLRP3 IL1B 24701565 188182 Positive_regulation NLRP3 TLR7 21533069 3051609 Positive_regulation NLRP3 TLR7 21850221 2542643 Positive_regulation NLRP3 TLR7 22484733 1957071 Positive_regulation NLRP3 TLR7 23666718 780730 Positive_regulation NLRP3 TLR7 23762026 3062083 Positive_regulation NLRP3 TLR7 24273750 864445 Positive_regulation NLRP3 TLR7 24966466 1759749 Positive_regulation NLRP3 TLR7 25525300 1763316 Positive_regulation NLRP3 TNF 22146561 124423 Positive_regulation NLRP3 TNF 22558291 2625020 Positive_regulation NLRP3 TNF 22558291 2625024 Positive_regulation NM EPHB2 24842369 1576263 Positive_regulation NM EPHB2 24842369 1576320 Positive_regulation NM IL1B 24151520 638783 Positive_regulation NM ITGB2 11457896 1519995 Positive_regulation NM ITGB2 11457896 1519996 Positive_regulation NM ITGB2 20119709 1644266 Positive_regulation NM ITGB2 8691137 1598425 Positive_regulation NM MIP 12771994 422594 Positive_regulation NM TLR7 24634497 1624632 Positive_regulation NM TNF 11097214 702131 Positive_regulation NM TNF 12137244 1738155 Positive_regulation NM TNF 18472833 1742101 Positive_regulation NM TNF 18472833 1742102 Positive_regulation NM TNF 18472833 1742103 Positive_regulation NM TNF 18472833 1742142 Positive_regulation NM TNF 18472868 1742338 Positive_regulation NM TNF 18472952 1743328 Positive_regulation NM TNF 18475441 1743786 Positive_regulation NM TNF 18475582 1744433 Positive_regulation NM TNF 22991570 815625 Positive_regulation NM TNF 24151520 638780 Positive_regulation NM TNF 24223056 824053 Positive_regulation NM TNF 24232096 569089 Positive_regulation NM TNF 24385881 3155772 Positive_regulation NM TNF 9271590 1601622 Positive_regulation NMNAT2 NMNAT3 24155910 2871339 Positive_regulation NNAT EPHB2 18591389 706336 Positive_regulation NNAT TNF 18591389 706335 Positive_regulation NNMT IL6 19216803 1503536 Positive_regulation NNMT IL6 21423603 2508090 Positive_regulation NNMT STAT3 19216803 1503534 Positive_regulation NNMT STAT3 19216803 1503535 Positive_regulation NNMT SYP 23764850 562414 Positive_regulation NOBOX ANGPT1 25329960 3017014 Positive_regulation NOD1 CD14 21785567 1222358 Positive_regulation NOD1 TLR7 22218461 1086180 Positive_regulation NOD1 TLR7 22577250 1749911 Positive_regulation NOD1 TNF 22203860 633908 Positive_regulation NOD2 EPHB2 25090227 2995096 Positive_regulation NOD2 NEDD9 23180782 2082334 Positive_regulation NOD2 TLR7 19911079 1213222 Positive_regulation NOD2 TLR7 21750585 1918493 Positive_regulation NOD2 TLR7 22218461 1086205 Positive_regulation NOD2 TLR7 22577250 1749921 Positive_regulation NOD2 TNF 21779525 2115055 Positive_regulation NOD2 TNF 22003428 2063 Positive_regulation NOD2 TNF 22203860 633912 Positive_regulation NOD2 TNF 24932916 2980524 Positive_regulation NOD2 TNF 24932916 2980529 Positive_regulation NODAL AXIN2 19064356 2250018 Positive_regulation NOG HBEGF 22157721 1717805 Positive_regulation NONO EPHB2 21368873 550867 Positive_regulation NONO EPHB2 24349210 2897141 Positive_regulation NONO RASD1 21915321 2553242 Positive_regulation NOS1 BLVRA 25206501 2004853 Positive_regulation NOS1 BLVRA 25206501 2004860 Positive_regulation NOS1 EPHB2 19343212 3043660 Positive_regulation NOS1 EPHB2 19343212 3043661 Positive_regulation NOS1 EPHB2 19343212 3043662 Positive_regulation NOS1 FAS 22824368 1724878 Positive_regulation NOS1 IL1B 11545250 1737853 Positive_regulation NOS1 IL1B 15040812 350453 Positive_regulation NOS1 IL1B 18472818 1741822 Positive_regulation NOS1 IL1B 25018923 1709699 Positive_regulation NOS1 S100B 20862385 513127 Positive_regulation NOS1 S100B 23705829 395952 Positive_regulation NOS1 TLR7 25309919 201198 Positive_regulation NOS1 TNF 17047310 1212353 Positive_regulation NOS1 TNF 18297215 652393 Positive_regulation NOS1 TNF 18475620 1744675 Positive_regulation NOS1 TNF 18922887 84788 Positive_regulation NOS1 TNF 18927622 3042107 Positive_regulation NOS1 TNF 19118493 651012 Positive_regulation NOS1 TNF 19707465 175866 Positive_regulation NOS1 TNF 21303534 379703 Positive_regulation NOS1 TNF 21826187 813068 Positive_regulation NOS1 TNF 22619548 1136961 Positive_regulation NOS1 TNF 23209478 1703312 Positive_regulation NOS1 TNF 23762128 819942 Positive_regulation NOS1 TNF 24086172 1226683 Positive_regulation NOS1 TNF 24098382 2856014 Positive_regulation NOS1 TNF 7530762 1589954 Positive_regulation NOS1 TP63 23226202 2723599 Positive_regulation NOS2 BLVRA 25206501 2004854 Positive_regulation NOS2 BLVRA 25206501 2004861 Positive_regulation NOS2 CD14 20011115 3045947 Positive_regulation NOS2 CD14 9792334 1763752 Positive_regulation NOS2 EPHB2 16091148 524445 Positive_regulation NOS2 EPHB2 22159280 83880 Positive_regulation NOS2 EPHB2 23666803 135518 Positive_regulation NOS2 EPHB2 23946691 1716135 Positive_regulation NOS2 EPHB2 23946691 1716143 Positive_regulation NOS2 EPHB2 25079440 1128783 Positive_regulation NOS2 EPHB2 25143805 206486 Positive_regulation NOS2 FAS 22110764 2573326 Positive_regulation NOS2 FAS 22824368 1724879 Positive_regulation NOS2 FOXO1 19584310 710416 Positive_regulation NOS2 FOXO1 19584310 710417 Positive_regulation NOS2 FOXO1 19584310 710420 Positive_regulation NOS2 FOXO1 19584310 710423 Positive_regulation NOS2 IL1B 11200365 1737607 Positive_regulation NOS2 IL1B 11200365 1737650 Positive_regulation NOS2 IL1B 11545250 1737854 Positive_regulation NOS2 IL1B 11577997 1737894 Positive_regulation NOS2 IL1B 15223606 1739753 Positive_regulation NOS2 IL1B 18472818 1741823 Positive_regulation NOS2 IL1B 22551254 292011 Positive_regulation NOS2 IL1B 25018923 1709700 Positive_regulation NOS2 IL1B 7530759 1589920 Positive_regulation NOS2 IL1B 7530759 1589921 Positive_regulation NOS2 ITGAL 14657223 1529949 Positive_regulation NOS2 ITGB2 24516666 2921374 Positive_regulation NOS2 LBP 23517687 294297 Positive_regulation NOS2 LBP 23517687 294308 Positive_regulation NOS2 MMP28 23894457 2824775 Positive_regulation NOS2 MMP7 23894457 2824791 Positive_regulation NOS2 NGFR 16144552 1654781 Positive_regulation NOS2 PLAT 24235858 1614621 Positive_regulation NOS2 PTGER2 19222857 1655620 Positive_regulation NOS2 S100B 20508809 512948 Positive_regulation NOS2 S100B 20672023 512971 Positive_regulation NOS2 S100B 20862385 513128 Positive_regulation NOS2 S100B 23705829 395953 Positive_regulation NOS2 SPHK1 20498849 2451159 Positive_regulation NOS2 TGM2 20052409 2436671 Positive_regulation NOS2 TLR7 20385024 290774 Positive_regulation NOS2 TLR7 22530722 3210396 Positive_regulation NOS2 TLR7 22530722 3210407 Positive_regulation NOS2 TLR7 22615562 3056703 Positive_regulation NOS2 TLR7 23637937 2786721 Positive_regulation NOS2 TLR7 23690823 637346 Positive_regulation NOS2 TLR7 24134665 3210762 Positive_regulation NOS2 TLR7 24134665 3210772 Positive_regulation NOS2 TLR7 24379524 1756133 Positive_regulation NOS2 TLR7 24479442 1667574 Positive_regulation NOS2 TLR7 24847328 912730 Positive_regulation NOS2 TLR7 25309919 201208 Positive_regulation NOS2 TNF 11213909 1737738 Positive_regulation NOS2 TNF 12137246 1738164 Positive_regulation NOS2 TNF 12172046 1632990 Positive_regulation NOS2 TNF 14527842 791934 Positive_regulation NOS2 TNF 14657222 1529929 Positive_regulation NOS2 TNF 15498105 390232 Positive_regulation NOS2 TNF 16018814 3096050 Positive_regulation NOS2 TNF 16354107 2368636 Positive_regulation NOS2 TNF 16606437 658632 Positive_regulation NOS2 TNF 17029647 1727733 Positive_regulation NOS2 TNF 17047310 1212354 Positive_regulation NOS2 TNF 18297215 652394 Positive_regulation NOS2 TNF 18461174 2388473 Positive_regulation NOS2 TNF 18475655 1745161 Positive_regulation NOS2 TNF 18475657 1745179 Positive_regulation NOS2 TNF 18927622 3042108 Positive_regulation NOS2 TNF 19060915 6693 Positive_regulation NOS2 TNF 19118493 651019 Positive_regulation NOS2 TNF 19118493 651020 Positive_regulation NOS2 TNF 19242068 736281 Positive_regulation NOS2 TNF 19463182 352907 Positive_regulation NOS2 TNF 19547716 1146847 Positive_regulation NOS2 TNF 19557162 3044210 Positive_regulation NOS2 TNF 19564950 1088479 Positive_regulation NOS2 TNF 19657383 2422801 Positive_regulation NOS2 TNF 19657383 2422803 Positive_regulation NOS2 TNF 19657383 2422804 Positive_regulation NOS2 TNF 19707465 175867 Positive_regulation NOS2 TNF 20236459 659519 Positive_regulation NOS2 TNF 20828402 1657155 Positive_regulation NOS2 TNF 21221075 1717673 Positive_regulation NOS2 TNF 21475693 1238348 Positive_regulation NOS2 TNF 21740583 627019 Positive_regulation NOS2 TNF 21792375 2208274 Positive_regulation NOS2 TNF 22069489 2569190 Positive_regulation NOS2 TNF 22069489 2569236 Positive_regulation NOS2 TNF 22069489 2569237 Positive_regulation NOS2 TNF 22069558 3181618 Positive_regulation NOS2 TNF 22447223 14582 Positive_regulation NOS2 TNF 22447223 14583 Positive_regulation NOS2 TNF 22447223 14599 Positive_regulation NOS2 TNF 22447223 14600 Positive_regulation NOS2 TNF 22447223 14604 Positive_regulation NOS2 TNF 22476916 1238784 Positive_regulation NOS2 TNF 22506619 451407 Positive_regulation NOS2 TNF 22551254 292010 Positive_regulation NOS2 TNF 22558451 2626147 Positive_regulation NOS2 TNF 22615562 3056741 Positive_regulation NOS2 TNF 22615562 3056747 Positive_regulation NOS2 TNF 22619548 1136962 Positive_regulation NOS2 TNF 22651808 1663297 Positive_regulation NOS2 TNF 22654792 875816 Positive_regulation NOS2 TNF 22754280 1224446 Positive_regulation NOS2 TNF 22824592 1046467 Positive_regulation NOS2 TNF 23133749 1028935 Positive_regulation NOS2 TNF 23243434 816493 Positive_regulation NOS2 TNF 23251037 1751087 Positive_regulation NOS2 TNF 23346188 817058 Positive_regulation NOS2 TNF 23365486 1751364 Positive_regulation NOS2 TNF 23365490 1751431 Positive_regulation NOS2 TNF 23512346 1606777 Positive_regulation NOS2 TNF 23527096 2769361 Positive_regulation NOS2 TNF 23548047 356238 Positive_regulation NOS2 TNF 23573152 818523 Positive_regulation NOS2 TNF 23678392 1681667 Positive_regulation NOS2 TNF 23717114 1614104 Positive_regulation NOS2 TNF 23717114 1614115 Positive_regulation NOS2 TNF 23724321 1152601 Positive_regulation NOS2 TNF 23724856 1674624 Positive_regulation NOS2 TNF 23762128 819943 Positive_regulation NOS2 TNF 23772116 2247873 Positive_regulation NOS2 TNF 23777554 1243730 Positive_regulation NOS2 TNF 23890248 1481401 Positive_regulation NOS2 TNF 23946691 1716134 Positive_regulation NOS2 TNF 23984387 183494 Positive_regulation NOS2 TNF 24039983 2845182 Positive_regulation NOS2 TNF 24086172 1226684 Positive_regulation NOS2 TNF 24086172 1226686 Positive_regulation NOS2 TNF 24086172 1226687 Positive_regulation NOS2 TNF 24086172 1226688 Positive_regulation NOS2 TNF 24098382 2856015 Positive_regulation NOS2 TNF 24171038 823207 Positive_regulation NOS2 TNF 24204674 2873199 Positive_regulation NOS2 TNF 24281071 501373 Positive_regulation NOS2 TNF 24392456 1495522 Positive_regulation NOS2 TNF 24405628 1667516 Positive_regulation NOS2 TNF 24594628 2929946 Positive_regulation NOS2 TNF 24596622 206183 Positive_regulation NOS2 TNF 24596622 206184 Positive_regulation NOS2 TNF 24618100 1667762 Positive_regulation NOS2 TNF 24646507 652067 Positive_regulation NOS2 TNF 24688408 3156205 Positive_regulation NOS2 TNF 24778996 3188209 Positive_regulation NOS2 TNF 24959077 1138253 Positive_regulation NOS2 TNF 25109716 1045933 Positive_regulation NOS2 TNF 25114952 3156839 Positive_regulation NOS2 TNF 25409514 3028768 Positive_regulation NOS2 TNF 25426114 915247 Positive_regulation NOS2 TNF 7519246 1589408 Positive_regulation NOS2 TNF 7530759 1589813 Positive_regulation NOS2 TNF 7530759 1589814 Positive_regulation NOS2 TNF 7530759 1589903 Positive_regulation NOS2 TNF 7530759 1589904 Positive_regulation NOS2 TNF 7530759 1589930 Positive_regulation NOS2 TNF 7530759 1589931 Positive_regulation NOS2 TNF 7530759 1589937 Positive_regulation NOS2 TNF 7530759 1589943 Positive_regulation NOS2 TNF 9104810 1600623 Positive_regulation NOS2 TNF 9670043 1603188 Positive_regulation NOS2 TNF 9883971 1764122 Positive_regulation NOS2 TP63 23226202 2723603 Positive_regulation NOS3 ALDH2 22606372 2116527 Positive_regulation NOS3 ANGPT1 16584574 279143 Positive_regulation NOS3 ANGPT1 18835934 707030 Positive_regulation NOS3 ANGPT1 18835934 707035 Positive_regulation NOS3 ANGPT1 21270241 717365 Positive_regulation NOS3 ANGPT1 21270241 717366 Positive_regulation NOS3 ANGPT1 21798594 2252780 Positive_regulation NOS3 ANGPT1 22454630 832627 Positive_regulation NOS3 ANGPT1 22454630 832628 Positive_regulation NOS3 ANGPT1 22454630 832644 Positive_regulation NOS3 ANGPT1 22454630 832645 Positive_regulation NOS3 ANGPT1 22454630 832666 Positive_regulation NOS3 ANGPT1 22611498 1145661 Positive_regulation NOS3 ANGPT1 25371820 1690116 Positive_regulation NOS3 BLVRA 25206501 2004855 Positive_regulation NOS3 BLVRA 25206501 2004862 Positive_regulation NOS3 CAPN8 22489274 1145587 Positive_regulation NOS3 EPHB2 18382618 831308 Positive_regulation NOS3 EPHB2 18382618 831374 Positive_regulation NOS3 EPHB2 21937726 1795107 Positive_regulation NOS3 EPHB2 22933112 724423 Positive_regulation NOS3 EPHB2 23300633 2734122 Positive_regulation NOS3 EPHB2 24222847 627824 Positive_regulation NOS3 EPHB2 24603335 572744 Positive_regulation NOS3 EPHB2 25460732 3094736 Positive_regulation NOS3 FAS 22824368 1724880 Positive_regulation NOS3 FOXO1 24379901 2227824 Positive_regulation NOS3 GLP1R 24843641 1494204 Positive_regulation NOS3 GPR115 22482044 661438 Positive_regulation NOS3 GPR132 22482044 661427 Positive_regulation NOS3 GPR87 22482044 661507 Positive_regulation NOS3 HBEGF 23760291 1709468 Positive_regulation NOS3 HBEGF 23977191 2838874 Positive_regulation NOS3 IL1B 10704145 1737021 Positive_regulation NOS3 IL1B 11545250 1737855 Positive_regulation NOS3 IL1B 18472818 1741824 Positive_regulation NOS3 IL1B 25018923 1709701 Positive_regulation NOS3 MAP2K6 22254061 2116073 Positive_regulation NOS3 NOSTRIN 23667810 3165627 Positive_regulation NOS3 NOSTRIN 24379783 963154 Positive_regulation NOS3 NOSTRIN 24957964 1764798 Positive_regulation NOS3 PECAM1 23785479 2806389 Positive_regulation NOS3 S100B 20862385 513129 Positive_regulation NOS3 S100B 23705829 395954 Positive_regulation NOS3 S1PR3 24830642 2970300 Positive_regulation NOS3 S1PR3 PMC4052545 2247041 Positive_regulation NOS3 S1PR3 PMC4052545 2247046 Positive_regulation NOS3 STK39 22916065 1613788 Positive_regulation NOS3 TLR7 25309919 201218 Positive_regulation NOS3 TNF 17047310 1212355 Positive_regulation NOS3 TNF 18297215 652395 Positive_regulation NOS3 TNF 18927622 3042109 Positive_regulation NOS3 TNF 19118493 651013 Positive_regulation NOS3 TNF 19118493 651018 Positive_regulation NOS3 TNF 19707465 175868 Positive_regulation NOS3 TNF 20361002 2214375 Positive_regulation NOS3 TNF 22619548 1136963 Positive_regulation NOS3 TNF 22802702 1714278 Positive_regulation NOS3 TNF 22802702 1714311 Positive_regulation NOS3 TNF 23359116 2744870 Positive_regulation NOS3 TNF 23762128 819944 Positive_regulation NOS3 TNF 24086172 1226685 Positive_regulation NOS3 TNF 24086172 1226689 Positive_regulation NOS3 TNF 24098382 2856016 Positive_regulation NOS3 TNF 24288605 3178209 Positive_regulation NOS3 TNF 24381514 3155628 Positive_regulation NOS3 TNF 24646507 652070 Positive_regulation NOS3 TNF 24968272 1127936 Positive_regulation NOS3 TNF 25120637 844976 Positive_regulation NOS3 TP63 23226202 2723607 Positive_regulation NOSTRIN NOS3 24957964 1764797 Positive_regulation NOTCH1 ANGPT1 23161900 91142 Positive_regulation NOTCH1 ANGPT1 23161900 91250 Positive_regulation NOTCH1 AXIN2 17984306 1547565 Positive_regulation NOTCH1 CCND1 18838555 1358284 Positive_regulation NOTCH1 CCND1 24744701 869124 Positive_regulation NOTCH1 EPHB2 16522205 249119 Positive_regulation NOTCH1 F2R 19165340 2404586 Positive_regulation NOTCH1 F2R 22952817 2684165 Positive_regulation NOTCH1 FOXO1 21804540 1961627 Positive_regulation NOTCH1 FOXO1 24551104 2923015 Positive_regulation NOTCH1 FUT4 18194540 242183 Positive_regulation NOTCH1 FUT4 18194540 242230 Positive_regulation NOTCH1 FZD4 22019198 2252863 Positive_regulation NOTCH1 HES2 22004682 1863856 Positive_regulation NOTCH1 HES2 24563863 187235 Positive_regulation NOTCH1 HES2 24563863 187263 Positive_regulation NOTCH1 JAG1 10748227 1515059 Positive_regulation NOTCH1 JAG1 15851488 1536001 Positive_regulation NOTCH1 JAG1 16604164 2013477 Positive_regulation NOTCH1 JAG1 17984306 1547527 Positive_regulation NOTCH1 JAG1 17984306 1547563 Positive_regulation NOTCH1 JAG1 17984306 1547610 Positive_regulation NOTCH1 JAG1 18194540 242223 Positive_regulation NOTCH1 JAG1 18552977 1908114 Positive_regulation NOTCH1 JAG1 19015735 2400933 Positive_regulation NOTCH1 JAG1 19936191 667316 Positive_regulation NOTCH1 JAG1 20010940 434198 Positive_regulation NOTCH1 JAG1 20016694 1160908 Positive_regulation NOTCH1 JAG1 20016694 1160909 Positive_regulation NOTCH1 JAG1 20346184 303917 Positive_regulation NOTCH1 JAG1 20529320 1161347 Positive_regulation NOTCH1 JAG1 21124801 2484102 Positive_regulation NOTCH1 JAG1 21124801 2484129 Positive_regulation NOTCH1 JAG1 21420373 3167916 Positive_regulation NOTCH1 JAG1 21549007 259708 Positive_regulation NOTCH1 JAG1 21764776 2065044 Positive_regulation NOTCH1 JAG1 21843347 1229484 Positive_regulation NOTCH1 JAG1 21854594 333163 Positive_regulation NOTCH1 JAG1 21887294 2549153 Positive_regulation NOTCH1 JAG1 22027644 809234 Positive_regulation NOTCH1 JAG1 22110751 2573275 Positive_regulation NOTCH1 JAG1 22355251 1914026 Positive_regulation NOTCH1 JAG1 22390640 124869 Positive_regulation NOTCH1 JAG1 22390640 124870 Positive_regulation NOTCH1 JAG1 22390640 124871 Positive_regulation NOTCH1 JAG1 22390640 124885 Positive_regulation NOTCH1 JAG1 22432025 2611624 Positive_regulation NOTCH1 JAG1 22487493 3207589 Positive_regulation NOTCH1 JAG1 22509166 956952 Positive_regulation NOTCH1 JAG1 22550518 3172997 Positive_regulation NOTCH1 JAG1 22558446 2626046 Positive_regulation NOTCH1 JAG1 22558446 2626094 Positive_regulation NOTCH1 JAG1 22558446 2626126 Positive_regulation NOTCH1 JAG1 22558462 2626153 Positive_regulation NOTCH1 JAG1 22715413 2653001 Positive_regulation NOTCH1 JAG1 22827778 1231050 Positive_regulation NOTCH1 JAG1 22937766 2236035 Positive_regulation NOTCH1 JAG1 22989188 387802 Positive_regulation NOTCH1 JAG1 23016862 692497 Positive_regulation NOTCH1 JAG1 23092791 1619988 Positive_regulation NOTCH1 JAG1 23118846 2711676 Positive_regulation NOTCH1 JAG1 23166366 805591 Positive_regulation NOTCH1 JAG1 23166366 805595 Positive_regulation NOTCH1 JAG1 23314952 3175711 Positive_regulation NOTCH1 JAG1 23342261 491883 Positive_regulation NOTCH1 JAG1 23530123 1570928 Positive_regulation NOTCH1 JAG1 23530123 1570958 Positive_regulation NOTCH1 JAG1 23533807 1154032 Positive_regulation NOTCH1 JAG1 23560082 2776640 Positive_regulation NOTCH1 JAG1 23759991 1107691 Positive_regulation NOTCH1 JAG1 23967210 2834820 Positive_regulation NOTCH1 JAG1 23967210 2834840 Positive_regulation NOTCH1 JAG1 23967210 2834841 Positive_regulation NOTCH1 JAG1 23967210 2834857 Positive_regulation NOTCH1 JAG1 24086636 2855228 Positive_regulation NOTCH1 JAG1 24113587 1113274 Positive_regulation NOTCH1 JAG1 24137453 2165918 Positive_regulation NOTCH1 JAG1 24172068 474018 Positive_regulation NOTCH1 JAG1 24317268 1703501 Positive_regulation NOTCH1 JAG1 24324509 639339 Positive_regulation NOTCH1 JAG1 24345875 453571 Positive_regulation NOTCH1 JAG1 24391922 2904949 Positive_regulation NOTCH1 JAG1 24465223 2355669 Positive_regulation NOTCH1 JAG1 24672751 3166370 Positive_regulation NOTCH1 JAG1 24672751 3166371 Positive_regulation NOTCH1 JAG1 24672751 3166378 Positive_regulation NOTCH1 JAG1 24672751 3166379 Positive_regulation NOTCH1 JAG1 24672751 3166386 Positive_regulation NOTCH1 JAG1 24672751 3166390 Positive_regulation NOTCH1 JAG1 24708907 6049 Positive_regulation NOTCH1 JAG1 24708907 6079 Positive_regulation NOTCH1 JAG1 24961530 452869 Positive_regulation NOTCH1 JAG1 24968269 1127932 Positive_regulation NOTCH1 JAG1 25255288 3010218 Positive_regulation NOTCH1 JAG1 25309874 948737 Positive_regulation NOTCH1 JAG1 25309874 948738 Positive_regulation NOTCH1 JAG1 25309874 948739 Positive_regulation NOTCH1 JAG1 25309874 948740 Positive_regulation NOTCH1 JAG1 25309874 948741 Positive_regulation NOTCH1 JAG1 25309874 948757 Positive_regulation NOTCH1 JAG1 25309874 948761 Positive_regulation NOTCH1 JAG1 25309874 948762 Positive_regulation NOTCH1 JAG1 25408867 608188 Positive_regulation NOTCH1 JAG1 25566499 949536 Positive_regulation NOTCH1 JAG1 25566499 949558 Positive_regulation NOTCH1 JAG1 PMC3624153 395796 Positive_regulation NOTCH1 JAG1 PMC3624153 395804 Positive_regulation NOTCH1 MAML3 16966428 1542443 Positive_regulation NOTCH1 MAML3 17998388 1547725 Positive_regulation NOTCH1 MAML3 19349467 1554430 Positive_regulation NOTCH1 MAML3 23284900 2731178 Positive_regulation NOTCH1 MAML3 25537633 1486027 Positive_regulation NOTCH1 MMP28 24358274 2899183 Positive_regulation NOTCH1 MMP7 22359542 2597561 Positive_regulation NOTCH1 MMP7 22359542 2597585 Positive_regulation NOTCH1 MMP7 23918941 1407109 Positive_regulation NOTCH1 MMP7 24358274 2899198 Positive_regulation NOTCH1 MMP7 24587996 187338 Positive_regulation NOTCH1 MMP7 24885920 1874562 Positive_regulation NOTCH1 NES 24931375 851281 Positive_regulation NOTCH1 NRARP 20724159 3203262 Positive_regulation NOTCH1 NRARP 21795391 1792890 Positive_regulation NOTCH1 PLAU 22004682 1863768 Positive_regulation NOTCH1 PLAU 22004682 1863769 Positive_regulation NOTCH1 PLAU 22004682 1863795 Positive_regulation NOTCH1 PLAU 22004682 1863796 Positive_regulation NOTCH1 PLAU 22004682 1863797 Positive_regulation NOTCH1 PLAU 22004682 1863804 Positive_regulation NOTCH1 PLAU 22004682 1863805 Positive_regulation NOTCH1 PLAU 25309874 948763 Positive_regulation NOTCH1 TLR7 23762089 637707 Positive_regulation NOTCH1 TMEM100 24395635 1414602 Positive_regulation NOTCH1 TMEM156 24395635 1414620 Positive_regulation NOTCH1 TMEM211 24395635 1414700 Positive_regulation NOTCH1 TMEM213 24395635 1414637 Positive_regulation NOTCH1 TNF 20011512 2433200 Positive_regulation NOTCH1 TNF 20011512 2433224 Positive_regulation NOTCH1 TNF 20814569 2473429 Positive_regulation NOTCH1 TNF 20814569 2473459 Positive_regulation NOTCH1 TNF 22190977 633823 Positive_regulation NOTCH1 TNF 22190977 633824 Positive_regulation NOTCH1 TNF 22190977 633880 Positive_regulation NOTCH2 ANGPT1 23161900 91144 Positive_regulation NOTCH2 AXIN2 17984306 1547570 Positive_regulation NOTCH2 CCND1 18838555 1358285 Positive_regulation NOTCH2 CCND1 24744701 869125 Positive_regulation NOTCH2 EPHB2 16522205 249120 Positive_regulation NOTCH2 F2R 19165340 2404587 Positive_regulation NOTCH2 FOXO1 24551104 2923016 Positive_regulation NOTCH2 FUT4 18194540 242194 Positive_regulation NOTCH2 FUT4 18194540 242241 Positive_regulation NOTCH2 FZD4 22019198 2252880 Positive_regulation NOTCH2 HES2 24563863 187242 Positive_regulation NOTCH2 HES2 24563863 187270 Positive_regulation NOTCH2 JAG1 15851488 1536003 Positive_regulation NOTCH2 JAG1 16604164 2013482 Positive_regulation NOTCH2 JAG1 17984306 1547531 Positive_regulation NOTCH2 JAG1 17984306 1547568 Positive_regulation NOTCH2 JAG1 17984306 1547611 Positive_regulation NOTCH2 JAG1 18552977 1908115 Positive_regulation NOTCH2 JAG1 18665263 2394153 Positive_regulation NOTCH2 JAG1 19015735 2400935 Positive_regulation NOTCH2 JAG1 19936191 667317 Positive_regulation NOTCH2 JAG1 20010940 434199 Positive_regulation NOTCH2 JAG1 20016694 1160911 Positive_regulation NOTCH2 JAG1 20529320 1161349 Positive_regulation NOTCH2 JAG1 21124801 2484104 Positive_regulation NOTCH2 JAG1 21124801 2484130 Positive_regulation NOTCH2 JAG1 21420373 3167918 Positive_regulation NOTCH2 JAG1 21549007 259709 Positive_regulation NOTCH2 JAG1 21764776 2065045 Positive_regulation NOTCH2 JAG1 21854594 333164 Positive_regulation NOTCH2 JAG1 21887294 2549154 Positive_regulation NOTCH2 JAG1 22110751 2573277 Positive_regulation NOTCH2 JAG1 22355251 1914028 Positive_regulation NOTCH2 JAG1 22390640 124877 Positive_regulation NOTCH2 JAG1 22390640 124878 Positive_regulation NOTCH2 JAG1 22390640 124879 Positive_regulation NOTCH2 JAG1 22390640 124886 Positive_regulation NOTCH2 JAG1 22432025 2611625 Positive_regulation NOTCH2 JAG1 22487493 3207590 Positive_regulation NOTCH2 JAG1 22509166 956953 Positive_regulation NOTCH2 JAG1 22550518 3173002 Positive_regulation NOTCH2 JAG1 22558446 2626051 Positive_regulation NOTCH2 JAG1 22558446 2626099 Positive_regulation NOTCH2 JAG1 22558446 2626129 Positive_regulation NOTCH2 JAG1 22558462 2626154 Positive_regulation NOTCH2 JAG1 22715413 2653002 Positive_regulation NOTCH2 JAG1 22827778 1231060 Positive_regulation NOTCH2 JAG1 22937766 2236036 Positive_regulation NOTCH2 JAG1 22989188 387804 Positive_regulation NOTCH2 JAG1 23016862 692505 Positive_regulation NOTCH2 JAG1 23092791 1619990 Positive_regulation NOTCH2 JAG1 23118846 2711677 Positive_regulation NOTCH2 JAG1 23166366 805592 Positive_regulation NOTCH2 JAG1 23166366 805596 Positive_regulation NOTCH2 JAG1 23314952 3175712 Positive_regulation NOTCH2 JAG1 23342261 491884 Positive_regulation NOTCH2 JAG1 23530123 1570931 Positive_regulation NOTCH2 JAG1 23530123 1570959 Positive_regulation NOTCH2 JAG1 23759991 1107692 Positive_regulation NOTCH2 JAG1 23967210 2834822 Positive_regulation NOTCH2 JAG1 23967210 2834843 Positive_regulation NOTCH2 JAG1 23967210 2834859 Positive_regulation NOTCH2 JAG1 24086636 2855229 Positive_regulation NOTCH2 JAG1 24113587 1113275 Positive_regulation NOTCH2 JAG1 24137453 2165919 Positive_regulation NOTCH2 JAG1 24172068 474019 Positive_regulation NOTCH2 JAG1 24317268 1703502 Positive_regulation NOTCH2 JAG1 24391922 2904950 Positive_regulation NOTCH2 JAG1 24465223 2355671 Positive_regulation NOTCH2 JAG1 24672751 3166372 Positive_regulation NOTCH2 JAG1 24672751 3166373 Positive_regulation NOTCH2 JAG1 24672751 3166380 Positive_regulation NOTCH2 JAG1 24672751 3166381 Positive_regulation NOTCH2 JAG1 24672751 3166387 Positive_regulation NOTCH2 JAG1 24672751 3166391 Positive_regulation NOTCH2 JAG1 24708907 6052 Positive_regulation NOTCH2 JAG1 24708907 6080 Positive_regulation NOTCH2 JAG1 24961530 452870 Positive_regulation NOTCH2 JAG1 24968269 1127933 Positive_regulation NOTCH2 JAG1 25255288 3010219 Positive_regulation NOTCH2 JAG1 25309874 948742 Positive_regulation NOTCH2 JAG1 25309874 948743 Positive_regulation NOTCH2 JAG1 25309874 948744 Positive_regulation NOTCH2 JAG1 25309874 948745 Positive_regulation NOTCH2 JAG1 25309874 948758 Positive_regulation NOTCH2 JAG1 25309874 948764 Positive_regulation NOTCH2 JAG1 25309874 948765 Positive_regulation NOTCH2 JAG1 25309874 948766 Positive_regulation NOTCH2 JAG1 25408867 608191 Positive_regulation NOTCH2 JAG1 25566499 949537 Positive_regulation NOTCH2 JAG1 25566499 949560 Positive_regulation NOTCH2 JAG1 PMC3624153 395798 Positive_regulation NOTCH2 MAML3 16966428 1542447 Positive_regulation NOTCH2 MAML3 17998388 1547728 Positive_regulation NOTCH2 MAML3 23284900 2731181 Positive_regulation NOTCH2 MAML3 25537633 1486030 Positive_regulation NOTCH2 MMP28 24358274 2899205 Positive_regulation NOTCH2 MMP7 22359542 2597562 Positive_regulation NOTCH2 MMP7 22359542 2597586 Positive_regulation NOTCH2 MMP7 23918941 1407111 Positive_regulation NOTCH2 MMP7 24358274 2899220 Positive_regulation NOTCH2 MMP7 24587996 187339 Positive_regulation NOTCH2 NES 24931375 851282 Positive_regulation NOTCH2 NRARP 20724159 3203263 Positive_regulation NOTCH2 NRARP 21795391 1792891 Positive_regulation NOTCH2 PLAU 22004682 1863806 Positive_regulation NOTCH2 PLAU 25309874 948767 Positive_regulation NOTCH2 TLR7 23762089 637717 Positive_regulation NOTCH2 TMEM100 24395635 1414771 Positive_regulation NOTCH2 TMEM156 24395635 1414789 Positive_regulation NOTCH2 TMEM211 24395635 1414869 Positive_regulation NOTCH2 TMEM213 24395635 1414806 Positive_regulation NOTCH2 TNF 20011512 2433201 Positive_regulation NOTCH2 TNF 20011512 2433202 Positive_regulation NOTCH2 TNF 20011512 2433219 Positive_regulation NOTCH2 TNF 20011512 2433221 Positive_regulation NOTCH2 TNF 20011512 2433223 Positive_regulation NOTCH2 TNF 20011512 2433225 Positive_regulation NOTCH2 TNF 22190977 633825 Positive_regulation NOTCH2 TNF 22190977 633826 Positive_regulation NOTCH2 TNF 22190977 633849 Positive_regulation NOTCH2 TNF 22190977 633869 Positive_regulation NOTCH2 TNF 22190977 633881 Positive_regulation NOTCH2 TNF 23531541 1103751 Positive_regulation NOTCH3 ANGPT1 23161900 91146 Positive_regulation NOTCH3 AXIN2 17984306 1547575 Positive_regulation NOTCH3 CCND1 18838555 1358286 Positive_regulation NOTCH3 CCND1 21743488 2140744 Positive_regulation NOTCH3 CCND1 24744701 869126 Positive_regulation NOTCH3 EPHB2 16522205 249121 Positive_regulation NOTCH3 EPHB2 25164432 1484769 Positive_regulation NOTCH3 F2R 19165340 2404588 Positive_regulation NOTCH3 FOXO1 24551104 2923017 Positive_regulation NOTCH3 FUT4 18194540 242205 Positive_regulation NOTCH3 FUT4 18194540 242252 Positive_regulation NOTCH3 FZD4 22019198 2252897 Positive_regulation NOTCH3 HES2 24563863 187249 Positive_regulation NOTCH3 HES2 24563863 187277 Positive_regulation NOTCH3 JAG1 15851488 1536004 Positive_regulation NOTCH3 JAG1 16604164 2013484 Positive_regulation NOTCH3 JAG1 17984306 1547535 Positive_regulation NOTCH3 JAG1 17984306 1547573 Positive_regulation NOTCH3 JAG1 17984306 1547612 Positive_regulation NOTCH3 JAG1 18552977 1908116 Positive_regulation NOTCH3 JAG1 19015735 2400937 Positive_regulation NOTCH3 JAG1 19936191 667318 Positive_regulation NOTCH3 JAG1 20010940 434200 Positive_regulation NOTCH3 JAG1 20016694 1160846 Positive_regulation NOTCH3 JAG1 20016694 1160913 Positive_regulation NOTCH3 JAG1 20529320 1161351 Positive_regulation NOTCH3 JAG1 21124801 2484106 Positive_regulation NOTCH3 JAG1 21124801 2484131 Positive_regulation NOTCH3 JAG1 21193734 717026 Positive_regulation NOTCH3 JAG1 21420373 3167920 Positive_regulation NOTCH3 JAG1 21549007 259710 Positive_regulation NOTCH3 JAG1 21764776 2065046 Positive_regulation NOTCH3 JAG1 21854594 333165 Positive_regulation NOTCH3 JAG1 21887294 2549155 Positive_regulation NOTCH3 JAG1 22087289 2571303 Positive_regulation NOTCH3 JAG1 22110751 2573279 Positive_regulation NOTCH3 JAG1 22390640 124891 Positive_regulation NOTCH3 JAG1 22432025 2611626 Positive_regulation NOTCH3 JAG1 22487493 3207591 Positive_regulation NOTCH3 JAG1 22509166 956951 Positive_regulation NOTCH3 JAG1 22509166 956954 Positive_regulation NOTCH3 JAG1 22550518 3173007 Positive_regulation NOTCH3 JAG1 22550518 3173264 Positive_regulation NOTCH3 JAG1 22558446 2626056 Positive_regulation NOTCH3 JAG1 22558446 2626104 Positive_regulation NOTCH3 JAG1 22558446 2626132 Positive_regulation NOTCH3 JAG1 22558462 2626155 Positive_regulation NOTCH3 JAG1 22715413 2653003 Positive_regulation NOTCH3 JAG1 22827778 1231070 Positive_regulation NOTCH3 JAG1 22937766 2236037 Positive_regulation NOTCH3 JAG1 22989188 387806 Positive_regulation NOTCH3 JAG1 23016862 692513 Positive_regulation NOTCH3 JAG1 23092791 1619992 Positive_regulation NOTCH3 JAG1 23118846 2711678 Positive_regulation NOTCH3 JAG1 23158439 358845 Positive_regulation NOTCH3 JAG1 23166366 805593 Positive_regulation NOTCH3 JAG1 23166366 805597 Positive_regulation NOTCH3 JAG1 23314952 3175713 Positive_regulation NOTCH3 JAG1 23342261 491885 Positive_regulation NOTCH3 JAG1 23530123 1570933 Positive_regulation NOTCH3 JAG1 23530123 1570961 Positive_regulation NOTCH3 JAG1 23759991 1107693 Positive_regulation NOTCH3 JAG1 23967210 2834824 Positive_regulation NOTCH3 JAG1 23967210 2834845 Positive_regulation NOTCH3 JAG1 23967210 2834861 Positive_regulation NOTCH3 JAG1 24086636 2855230 Positive_regulation NOTCH3 JAG1 24113587 1113276 Positive_regulation NOTCH3 JAG1 24137453 2165920 Positive_regulation NOTCH3 JAG1 24172068 474020 Positive_regulation NOTCH3 JAG1 24317268 1703503 Positive_regulation NOTCH3 JAG1 24391922 2904951 Positive_regulation NOTCH3 JAG1 24465223 2355673 Positive_regulation NOTCH3 JAG1 24672751 3166374 Positive_regulation NOTCH3 JAG1 24672751 3166375 Positive_regulation NOTCH3 JAG1 24672751 3166382 Positive_regulation NOTCH3 JAG1 24672751 3166383 Positive_regulation NOTCH3 JAG1 24672751 3166388 Positive_regulation NOTCH3 JAG1 24672751 3166392 Positive_regulation NOTCH3 JAG1 24708907 6055 Positive_regulation NOTCH3 JAG1 24708907 6081 Positive_regulation NOTCH3 JAG1 24961530 452871 Positive_regulation NOTCH3 JAG1 24968269 1127934 Positive_regulation NOTCH3 JAG1 25255288 3010220 Positive_regulation NOTCH3 JAG1 25309874 948746 Positive_regulation NOTCH3 JAG1 25309874 948747 Positive_regulation NOTCH3 JAG1 25309874 948748 Positive_regulation NOTCH3 JAG1 25309874 948749 Positive_regulation NOTCH3 JAG1 25309874 948759 Positive_regulation NOTCH3 JAG1 25309874 948768 Positive_regulation NOTCH3 JAG1 25309874 948769 Positive_regulation NOTCH3 JAG1 25309874 948770 Positive_regulation NOTCH3 JAG1 25408867 608194 Positive_regulation NOTCH3 JAG1 25566499 949538 Positive_regulation NOTCH3 JAG1 25566499 949563 Positive_regulation NOTCH3 JAG1 PMC3624153 395800 Positive_regulation NOTCH3 MAML3 16966428 1542451 Positive_regulation NOTCH3 MAML3 17998388 1547731 Positive_regulation NOTCH3 MAML3 23284900 2731184 Positive_regulation NOTCH3 MAML3 25537633 1486033 Positive_regulation NOTCH3 MMP28 24358274 2899227 Positive_regulation NOTCH3 MMP7 22359542 2597563 Positive_regulation NOTCH3 MMP7 22359542 2597587 Positive_regulation NOTCH3 MMP7 23918941 1407113 Positive_regulation NOTCH3 MMP7 24358274 2899242 Positive_regulation NOTCH3 MMP7 24587996 187340 Positive_regulation NOTCH3 NES 24931375 851283 Positive_regulation NOTCH3 NRARP 20724159 3203264 Positive_regulation NOTCH3 NRARP 21795391 1792892 Positive_regulation NOTCH3 PLAU 22004682 1863807 Positive_regulation NOTCH3 PLAU 25309874 948771 Positive_regulation NOTCH3 TLR7 23762089 637727 Positive_regulation NOTCH3 TMEM100 24395635 1414940 Positive_regulation NOTCH3 TMEM156 24395635 1414958 Positive_regulation NOTCH3 TMEM211 24395635 1415038 Positive_regulation NOTCH3 TMEM213 24395635 1414975 Positive_regulation NOTCH3 TNF 20011512 2433203 Positive_regulation NOTCH3 TNF 20011512 2433226 Positive_regulation NOTCH3 TNF 22190977 633827 Positive_regulation NOTCH3 TNF 22190977 633828 Positive_regulation NOTCH3 TNF 22190977 633882 Positive_regulation NOTCH4 ANGPT1 23161900 91148 Positive_regulation NOTCH4 ANGPT1 23161900 91252 Positive_regulation NOTCH4 AXIN2 17984306 1547580 Positive_regulation NOTCH4 CCND1 18838555 1358287 Positive_regulation NOTCH4 CCND1 24744701 869127 Positive_regulation NOTCH4 EPHB2 16522205 249122 Positive_regulation NOTCH4 F2R 19165340 2404589 Positive_regulation NOTCH4 FOXO1 24551104 2923018 Positive_regulation NOTCH4 FUT4 18194540 242216 Positive_regulation NOTCH4 FUT4 18194540 242263 Positive_regulation NOTCH4 FZD4 22019198 2252914 Positive_regulation NOTCH4 HES2 24563863 187256 Positive_regulation NOTCH4 HES2 24563863 187284 Positive_regulation NOTCH4 JAG1 15851488 1536005 Positive_regulation NOTCH4 JAG1 16604164 2013486 Positive_regulation NOTCH4 JAG1 17984306 1547539 Positive_regulation NOTCH4 JAG1 17984306 1547578 Positive_regulation NOTCH4 JAG1 17984306 1547613 Positive_regulation NOTCH4 JAG1 18552977 1908117 Positive_regulation NOTCH4 JAG1 19015735 2400939 Positive_regulation NOTCH4 JAG1 19936191 667319 Positive_regulation NOTCH4 JAG1 20010940 434201 Positive_regulation NOTCH4 JAG1 20016694 1160915 Positive_regulation NOTCH4 JAG1 20529320 1161353 Positive_regulation NOTCH4 JAG1 21124801 2484108 Positive_regulation NOTCH4 JAG1 21124801 2484132 Positive_regulation NOTCH4 JAG1 21420373 3167922 Positive_regulation NOTCH4 JAG1 21549007 259711 Positive_regulation NOTCH4 JAG1 21764776 2065047 Positive_regulation NOTCH4 JAG1 21854594 333166 Positive_regulation NOTCH4 JAG1 21887294 2549156 Positive_regulation NOTCH4 JAG1 22110751 2573281 Positive_regulation NOTCH4 JAG1 22390640 124892 Positive_regulation NOTCH4 JAG1 22432025 2611627 Positive_regulation NOTCH4 JAG1 22487493 3207592 Positive_regulation NOTCH4 JAG1 22509166 956955 Positive_regulation NOTCH4 JAG1 22550518 3173012 Positive_regulation NOTCH4 JAG1 22558446 2626061 Positive_regulation NOTCH4 JAG1 22558446 2626109 Positive_regulation NOTCH4 JAG1 22558446 2626135 Positive_regulation NOTCH4 JAG1 22558462 2626156 Positive_regulation NOTCH4 JAG1 22715413 2653004 Positive_regulation NOTCH4 JAG1 22827778 1231080 Positive_regulation NOTCH4 JAG1 22937766 2236038 Positive_regulation NOTCH4 JAG1 22989188 387808 Positive_regulation NOTCH4 JAG1 23016862 692521 Positive_regulation NOTCH4 JAG1 23092791 1619994 Positive_regulation NOTCH4 JAG1 23118846 2711679 Positive_regulation NOTCH4 JAG1 23166366 805594 Positive_regulation NOTCH4 JAG1 23166366 805598 Positive_regulation NOTCH4 JAG1 23314952 3175714 Positive_regulation NOTCH4 JAG1 23342261 491886 Positive_regulation NOTCH4 JAG1 23530123 1570936 Positive_regulation NOTCH4 JAG1 23530123 1570964 Positive_regulation NOTCH4 JAG1 23759991 1107694 Positive_regulation NOTCH4 JAG1 23967210 2834826 Positive_regulation NOTCH4 JAG1 23967210 2834847 Positive_regulation NOTCH4 JAG1 23967210 2834863 Positive_regulation NOTCH4 JAG1 24086636 2855231 Positive_regulation NOTCH4 JAG1 24113587 1113277 Positive_regulation NOTCH4 JAG1 24137453 2165921 Positive_regulation NOTCH4 JAG1 24172068 474021 Positive_regulation NOTCH4 JAG1 24317268 1703504 Positive_regulation NOTCH4 JAG1 24391922 2904952 Positive_regulation NOTCH4 JAG1 24465223 2355675 Positive_regulation NOTCH4 JAG1 24672751 3166376 Positive_regulation NOTCH4 JAG1 24672751 3166377 Positive_regulation NOTCH4 JAG1 24672751 3166384 Positive_regulation NOTCH4 JAG1 24672751 3166385 Positive_regulation NOTCH4 JAG1 24672751 3166389 Positive_regulation NOTCH4 JAG1 24672751 3166393 Positive_regulation NOTCH4 JAG1 24708907 6058 Positive_regulation NOTCH4 JAG1 24708907 6082 Positive_regulation NOTCH4 JAG1 24961530 452872 Positive_regulation NOTCH4 JAG1 24968269 1127935 Positive_regulation NOTCH4 JAG1 25255288 3010221 Positive_regulation NOTCH4 JAG1 25309874 948750 Positive_regulation NOTCH4 JAG1 25309874 948751 Positive_regulation NOTCH4 JAG1 25309874 948752 Positive_regulation NOTCH4 JAG1 25309874 948753 Positive_regulation NOTCH4 JAG1 25309874 948760 Positive_regulation NOTCH4 JAG1 25309874 948772 Positive_regulation NOTCH4 JAG1 25309874 948773 Positive_regulation NOTCH4 JAG1 25309874 948774 Positive_regulation NOTCH4 JAG1 25408867 608197 Positive_regulation NOTCH4 JAG1 25566499 949539 Positive_regulation NOTCH4 JAG1 25566499 949565 Positive_regulation NOTCH4 JAG1 PMC3624153 395802 Positive_regulation NOTCH4 MAML3 16966428 1542455 Positive_regulation NOTCH4 MAML3 17998388 1547734 Positive_regulation NOTCH4 MAML3 23284900 2731187 Positive_regulation NOTCH4 MAML3 25537633 1486036 Positive_regulation NOTCH4 MMP28 24358274 2899249 Positive_regulation NOTCH4 MMP7 22359542 2597564 Positive_regulation NOTCH4 MMP7 22359542 2597588 Positive_regulation NOTCH4 MMP7 23918941 1407115 Positive_regulation NOTCH4 MMP7 24358274 2899264 Positive_regulation NOTCH4 MMP7 24587996 187341 Positive_regulation NOTCH4 NES 24931375 851284 Positive_regulation NOTCH4 NRARP 20724159 3203265 Positive_regulation NOTCH4 NRARP 21795391 1792893 Positive_regulation NOTCH4 PLAU 22004682 1863808 Positive_regulation NOTCH4 PLAU 25309874 948775 Positive_regulation NOTCH4 TLR7 23762089 637737 Positive_regulation NOTCH4 TMEM100 24395635 1415109 Positive_regulation NOTCH4 TMEM156 24395635 1415127 Positive_regulation NOTCH4 TMEM211 24395635 1415207 Positive_regulation NOTCH4 TMEM213 24395635 1415144 Positive_regulation NOTCH4 TNF 20011512 2433204 Positive_regulation NOTCH4 TNF 20011512 2433227 Positive_regulation NOTCH4 TNF 22190977 633829 Positive_regulation NOTCH4 TNF 22190977 633830 Positive_regulation NOTCH4 TNF 22190977 633862 Positive_regulation NOTCH4 TNF 22190977 633883 Positive_regulation NOTO FOXA1 23383217 2749515 Positive_regulation NOV CTGF 21931747 2554318 Positive_regulation NOV FOXO1 23705021 2797493 Positive_regulation NOV FOXO1 23705021 2797494 Positive_regulation NOV TNF 24722330 2951170 Positive_regulation NOX1 EPHB2 22559742 398599 Positive_regulation NOX1 EPHB2 22933112 724427 Positive_regulation NOX1 EPHB2 24132149 1113498 Positive_regulation NOX1 EPHB2 25147438 1761258 Positive_regulation NOX1 F2R 22167343 142825 Positive_regulation NOX1 F2R 24624928 511378 Positive_regulation NOX1 F3 22167343 142826 Positive_regulation NOX1 ITGB2 23508943 906577 Positive_regulation NOX1 MAP2K6 23549262 1104364 Positive_regulation NOX1 TF 3007099 795584 Positive_regulation NOX1 TLR7 24823882 1126668 Positive_regulation NOX1 TLR7 25437036 2234021 Positive_regulation NOX1 TNF 1357073 1528552 Positive_regulation NOX1 TNF 15157285 277610 Positive_regulation NOX1 TNF 15157285 277629 Positive_regulation NOX1 TNF 17698589 1546812 Positive_regulation NOX1 TNF 20068131 712459 Positive_regulation NOX1 TNF 20079746 1642282 Positive_regulation NOX1 TNF 20338038 255706 Positive_regulation NOX1 TNF 21645369 2111703 Positive_regulation NOX1 TNF 21670490 2176162 Positive_regulation NOX1 TNF 21966220 3209155 Positive_regulation NOX1 TNF 22346117 1769041 Positive_regulation NOX1 TNF 22530124 2009517 Positive_regulation NOX1 TNF 22737658 730392 Positive_regulation NOX1 TNF 23125837 960159 Positive_regulation NOX1 TNF 23317476 1155730 Positive_regulation NOX1 TNF 23497394 410140 Positive_regulation NOX1 TNF 23555077 180702 Positive_regulation NOX1 TNF 23573120 818377 Positive_regulation NOX1 TNF 23671702 2792478 Positive_regulation NOX1 TNF 23671702 2792525 Positive_regulation NOX1 TNF 23691105 2794532 Positive_regulation NOX1 TNF 23915963 1733939 Positive_regulation NOX1 TNF 24392268 686188 Positive_regulation NOX1 TNF 24396568 2227993 Positive_regulation NOX1 TNF 24396568 2227997 Positive_regulation NOX1 TNF 24788542 2959142 Positive_regulation NOX1 TNF 24803980 2228701 Positive_regulation NOX1 TNF 24911209 851268 Positive_regulation NOX1 TNF 25343008 3180521 Positive_regulation NOX1 TNF 25437036 2234020 Positive_regulation NOX1 TNF PMC2833773 134318 Positive_regulation NOX1 TNF PMC4053802 2247125 Positive_regulation NOX1 TNS1 23554738 1226154 Positive_regulation NOX1 TP63 9064349 1600433 Positive_regulation NOX3 EPHB2 22559742 398600 Positive_regulation NOX3 EPHB2 22933112 724429 Positive_regulation NOX3 EPHB2 25147438 1761259 Positive_regulation NOX3 F2R 22167343 142828 Positive_regulation NOX3 F2R 24624928 511379 Positive_regulation NOX3 F3 22167343 142829 Positive_regulation NOX3 ITGB2 23508943 906580 Positive_regulation NOX3 MAP2K6 23549262 1104376 Positive_regulation NOX3 TF 3007099 795585 Positive_regulation NOX3 TLR7 24823882 1126678 Positive_regulation NOX3 TLR7 25437036 2234032 Positive_regulation NOX3 TNF 1357073 1528554 Positive_regulation NOX3 TNF 15157285 277611 Positive_regulation NOX3 TNF 15157285 277644 Positive_regulation NOX3 TNF 17698589 1546815 Positive_regulation NOX3 TNF 20068131 712460 Positive_regulation NOX3 TNF 20079746 1642283 Positive_regulation NOX3 TNF 20338038 255707 Positive_regulation NOX3 TNF 21645369 2111704 Positive_regulation NOX3 TNF 21966220 3209156 Positive_regulation NOX3 TNF 22346117 1769042 Positive_regulation NOX3 TNF 22530124 2009519 Positive_regulation NOX3 TNF 22737658 730393 Positive_regulation NOX3 TNF 23317476 1155731 Positive_regulation NOX3 TNF 23555077 180704 Positive_regulation NOX3 TNF 23573120 818378 Positive_regulation NOX3 TNF 23671702 2792479 Positive_regulation NOX3 TNF 23671702 2792526 Positive_regulation NOX3 TNF 23691105 2794533 Positive_regulation NOX3 TNF 23915963 1733940 Positive_regulation NOX3 TNF 24396568 2227994 Positive_regulation NOX3 TNF 24396568 2227998 Positive_regulation NOX3 TNF 24788542 2959143 Positive_regulation NOX3 TNF 24803980 2228702 Positive_regulation NOX3 TNF 24911209 851269 Positive_regulation NOX3 TNF 25343008 3180523 Positive_regulation NOX3 TNF 25437036 2234031 Positive_regulation NOX3 TNF PMC2833773 134319 Positive_regulation NOX3 TNF PMC4053802 2247126 Positive_regulation NOX3 TNS1 23554738 1226155 Positive_regulation NOX3 TP63 9064349 1600435 Positive_regulation NOX4 EPHB2 22140508 2574864 Positive_regulation NOX4 EPHB2 22559742 398601 Positive_regulation NOX4 EPHB2 22933112 724431 Positive_regulation NOX4 EPHB2 25147438 1761260 Positive_regulation NOX4 F2R 22167343 142831 Positive_regulation NOX4 F2R 24624928 511380 Positive_regulation NOX4 F3 22167343 142832 Positive_regulation NOX4 IL1B 24145286 2185081 Positive_regulation NOX4 ITGB2 23508943 906583 Positive_regulation NOX4 MAP2K6 23549262 1104388 Positive_regulation NOX4 TF 3007099 795586 Positive_regulation NOX4 TLR7 24823882 1126688 Positive_regulation NOX4 TLR7 25437036 2234043 Positive_regulation NOX4 TNF 1357073 1528556 Positive_regulation NOX4 TNF 15157285 277612 Positive_regulation NOX4 TNF 15157285 277659 Positive_regulation NOX4 TNF 17698589 1546818 Positive_regulation NOX4 TNF 20068131 712461 Positive_regulation NOX4 TNF 20079746 1642284 Positive_regulation NOX4 TNF 20338038 255708 Positive_regulation NOX4 TNF 21645369 2111705 Positive_regulation NOX4 TNF 21966220 3209157 Positive_regulation NOX4 TNF 22346117 1769043 Positive_regulation NOX4 TNF 22530124 2009521 Positive_regulation NOX4 TNF 22737658 730394 Positive_regulation NOX4 TNF 23125837 960160 Positive_regulation NOX4 TNF 23317476 1155732 Positive_regulation NOX4 TNF 23555077 180706 Positive_regulation NOX4 TNF 23573120 818379 Positive_regulation NOX4 TNF 23671702 2792480 Positive_regulation NOX4 TNF 23671702 2792527 Positive_regulation NOX4 TNF 23691105 2794534 Positive_regulation NOX4 TNF 23915963 1733941 Positive_regulation NOX4 TNF 24392268 686189 Positive_regulation NOX4 TNF 24396568 2227995 Positive_regulation NOX4 TNF 24396568 2227999 Positive_regulation NOX4 TNF 24646507 652068 Positive_regulation NOX4 TNF 24646507 652072 Positive_regulation NOX4 TNF 24646507 652073 Positive_regulation NOX4 TNF 24788542 2959144 Positive_regulation NOX4 TNF 24803980 2228703 Positive_regulation NOX4 TNF 24911209 851270 Positive_regulation NOX4 TNF 25343008 3180525 Positive_regulation NOX4 TNF 25437036 2234042 Positive_regulation NOX4 TNF PMC2833773 134320 Positive_regulation NOX4 TNF PMC4053802 2247127 Positive_regulation NOX4 TNS1 23554738 1226156 Positive_regulation NOX4 TP63 9064349 1600437 Positive_regulation NOX5 EPHB2 22559742 398598 Positive_regulation NOX5 EPHB2 22933112 724416 Positive_regulation NOX5 EPHB2 24505490 2921062 Positive_regulation NOX5 EPHB2 25147438 1761257 Positive_regulation NOX5 F2R 22167343 142817 Positive_regulation NOX5 F2R 24624928 511377 Positive_regulation NOX5 F3 22167343 142818 Positive_regulation NOX5 ITGB2 23508943 906539 Positive_regulation NOX5 MAP2K6 23549262 1104228 Positive_regulation NOX5 TF 3007099 795583 Positive_regulation NOX5 TLR7 24823882 1126658 Positive_regulation NOX5 TLR7 25437036 2234010 Positive_regulation NOX5 TNF 1357073 1528543 Positive_regulation NOX5 TNF 15157285 277609 Positive_regulation NOX5 TNF 15157285 277614 Positive_regulation NOX5 TNF 17698589 1546805 Positive_regulation NOX5 TNF 20068131 712458 Positive_regulation NOX5 TNF 20079746 1642281 Positive_regulation NOX5 TNF 20338038 255705 Positive_regulation NOX5 TNF 21645369 2111702 Positive_regulation NOX5 TNF 21966220 3209154 Positive_regulation NOX5 TNF 22346117 1769040 Positive_regulation NOX5 TNF 22530124 2009511 Positive_regulation NOX5 TNF 22737658 730391 Positive_regulation NOX5 TNF 23317476 1155728 Positive_regulation NOX5 TNF 23555077 180696 Positive_regulation NOX5 TNF 23573120 818376 Positive_regulation NOX5 TNF 23671702 2792474 Positive_regulation NOX5 TNF 23671702 2792523 Positive_regulation NOX5 TNF 23691105 2794531 Positive_regulation NOX5 TNF 23915963 1733938 Positive_regulation NOX5 TNF 24396568 2227992 Positive_regulation NOX5 TNF 24396568 2227996 Positive_regulation NOX5 TNF 24788542 2959140 Positive_regulation NOX5 TNF 24803980 2228700 Positive_regulation NOX5 TNF 24911209 851267 Positive_regulation NOX5 TNF 25343008 3180519 Positive_regulation NOX5 TNF 25437036 2234009 Positive_regulation NOX5 TNF PMC2833773 134317 Positive_regulation NOX5 TNF PMC4053802 2247124 Positive_regulation NOX5 TNS1 23554738 1226153 Positive_regulation NOX5 TP63 9064349 1600431 Positive_regulation NPAS2 RORC 18454201 2305289 Positive_regulation NPEPPS EPHB2 23991415 183762 Positive_regulation NPEPPS MAP2K6 23991415 183770 Positive_regulation NPEPPS TNF 22264230 124593 Positive_regulation NPNT BMP4 21937601 703062 Positive_regulation NPNT MIR378A 25006962 2987325 Positive_regulation NPPA EDN2 24782788 964847 Positive_regulation NPPA GLP1R 23777457 509893 Positive_regulation NPPA GLP1R 24327600 787520 Positive_regulation NPPA GLP1R 24498905 510922 Positive_regulation NPPA GLP1R 24498905 510923 Positive_regulation NPPA GLP1R 25061556 1888236 Positive_regulation NPPA MAP2K6 20802223 2253152 Positive_regulation NPPA MAP2K6 20802223 2253169 Positive_regulation NPPA MAP2K6 20802223 2253173 Positive_regulation NPPA OXTR 25279805 3012223 Positive_regulation NPPA RGS2 20352235 142265 Positive_regulation NPPA TNF 24369440 1755943 Positive_regulation NPR1 TNF 24369440 1755935 Positive_regulation NPR1 TNF 24369440 1755944 Positive_regulation NPS CD14 23803652 1108020 Positive_regulation NPS EPHB2 24624962 1921247 Positive_regulation NPS FOLR1 22027239 1921110 Positive_regulation NPS FOLR1 22470431 2614147 Positive_regulation NPS JAG1 25009466 869662 Positive_regulation NPS LBP 23803652 1108021 Positive_regulation NPS MMP7 23995118 3136927 Positive_regulation NPS MUC16 21283816 2498404 Positive_regulation NPS MUC16 21283816 2498449 Positive_regulation NPS TNF 23819099 1082871 Positive_regulation NPS TNF 24369440 1755934 Positive_regulation NPS TNF 24369440 1755942 Positive_regulation NPS TNF 24658543 2937799 Positive_regulation NPS TNF 24949448 192691 Positive_regulation NPSR1 GPR115 21437045 1162408 Positive_regulation NPSR1 GPR132 21437045 1162397 Positive_regulation NPSR1 GPR87 21437045 1162477 Positive_regulation NPTX1 TNF 12186649 994874 Positive_regulation NPTX2 TNF 12186649 994876 Positive_regulation NPY EPHB2 18382618 831309 Positive_regulation NPY FAS 24341420 295592 Positive_regulation NPY FOXO1 22876196 2337371 Positive_regulation NPY FOXO1 22876196 2337372 Positive_regulation NPY FOXO1 22876196 2337402 Positive_regulation NPY FOXO1 24798184 3141735 Positive_regulation NPY FOXO1 25343030 848253 Positive_regulation NPY IL1B 25221996 3007281 Positive_regulation NPY IRS4 24567904 1887803 Positive_regulation NPY TNF 16277701 104856 Positive_regulation NPY TNF 18836554 2397379 Positive_regulation NPY TNF 18836554 2397387 Positive_regulation NPY4R EPHB2 25254549 2364778 Positive_regulation NPY4R RNASE1 9606212 1467788 Positive_regulation NPY4R RNASE7 9606212 1467796 Positive_regulation NPY4R TNF 24350059 946799 Positive_regulation NPY6R EPHB2 16674821 1624918 Positive_regulation NPY6R EPHB2 22567280 622864 Positive_regulation NPY6R EPHB2 23427196 780084 Positive_regulation NR0B1 TNF 19562033 2420163 Positive_regulation NR0B1 TNF 20181058 1625893 Positive_regulation NR0B1 TNF 20439544 1558181 Positive_regulation NR0B1 TNF 22844504 2668454 Positive_regulation NR0B2 TLR7 23429360 836755 Positive_regulation NR1I2 CYP24A1 19240808 2014609 Positive_regulation NR2F1 BCL2 24212637 497872 Positive_regulation NR2F1 BMP1 24058409 2847273 Positive_regulation NR2F1 BMP10 24058409 2847281 Positive_regulation NR2F1 BMP15 24058409 2847274 Positive_regulation NR2F1 BMP2 24058409 2847275 Positive_regulation NR2F1 BMP3 24058409 2847276 Positive_regulation NR2F1 BMP4 24058409 2847277 Positive_regulation NR2F1 BMP5 24058409 2847278 Positive_regulation NR2F1 BMP6 24058409 2847279 Positive_regulation NR2F1 BMP7 24058409 2847280 Positive_regulation NR2F1 CCAR2 23887938 2091531 Positive_regulation NR2F1 CTSD 24212637 497871 Positive_regulation NR2F1 EMX2 20862356 2291766 Positive_regulation NR2F1 ERBB2 23785296 2346925 Positive_regulation NR2F1 FGF1 18625063 2000505 Positive_regulation NR2F1 FGF1 18625063 2000506 Positive_regulation NR2F1 FGF10 18625063 2000507 Positive_regulation NR2F1 FGF10 18625063 2000508 Positive_regulation NR2F1 FGF11 18625063 2000509 Positive_regulation NR2F1 FGF11 18625063 2000510 Positive_regulation NR2F1 FGF12 18625063 2000511 Positive_regulation NR2F1 FGF12 18625063 2000512 Positive_regulation NR2F1 FGF13 18625063 2000513 Positive_regulation NR2F1 FGF13 18625063 2000514 Positive_regulation NR2F1 FGF14 18625063 2000515 Positive_regulation NR2F1 FGF14 18625063 2000516 Positive_regulation NR2F1 FGF16 18625063 2000517 Positive_regulation NR2F1 FGF16 18625063 2000518 Positive_regulation NR2F1 FGF17 18625063 2000519 Positive_regulation NR2F1 FGF17 18625063 2000520 Positive_regulation NR2F1 FGF18 18625063 2000521 Positive_regulation NR2F1 FGF18 18625063 2000522 Positive_regulation NR2F1 FGF19 18625063 2000523 Positive_regulation NR2F1 FGF19 18625063 2000524 Positive_regulation NR2F1 FGF2 18625063 2000525 Positive_regulation NR2F1 FGF2 18625063 2000526 Positive_regulation NR2F1 FGF20 18625063 2000527 Positive_regulation NR2F1 FGF20 18625063 2000528 Positive_regulation NR2F1 FGF21 18625063 2000529 Positive_regulation NR2F1 FGF21 18625063 2000530 Positive_regulation NR2F1 FGF22 18625063 2000531 Positive_regulation NR2F1 FGF22 18625063 2000532 Positive_regulation NR2F1 FGF23 18625063 2000533 Positive_regulation NR2F1 FGF23 18625063 2000534 Positive_regulation NR2F1 FGF3 18625063 2000535 Positive_regulation NR2F1 FGF3 18625063 2000536 Positive_regulation NR2F1 FGF4 18625063 2000537 Positive_regulation NR2F1 FGF4 18625063 2000538 Positive_regulation NR2F1 FGF5 18625063 2000539 Positive_regulation NR2F1 FGF5 18625063 2000540 Positive_regulation NR2F1 FGF6 18625063 2000541 Positive_regulation NR2F1 FGF6 18625063 2000542 Positive_regulation NR2F1 FGF7 18625063 2000543 Positive_regulation NR2F1 FGF7 18625063 2000544 Positive_regulation NR2F1 FGF8 18625063 2000545 Positive_regulation NR2F1 FGF8 18625063 2000546 Positive_regulation NR2F1 FGF9 18625063 2000547 Positive_regulation NR2F1 FGF9 18625063 2000548 Positive_regulation NR2F1 HLA-DRB1 22007304 1145381 Positive_regulation NR2F1 HNF1A 22007304 1145380 Positive_regulation NR2F1 HNF4A 22007304 1145382 Positive_regulation NR2F1 SUZ12 23666625 2088335 Positive_regulation NR3C2 ITGAL 2952751 1579185 Positive_regulation NR3C2 TLR7 24705920 2949272 Positive_regulation NR3C2 TNF 22547990 3152589 Positive_regulation NR4A2 EPHB2 19522012 3170474 Positive_regulation NR4A2 EPHB2 19522012 3170494 Positive_regulation NR4A2 EPHB2 19522012 3170535 Positive_regulation NR4A2 FOXA1 25249938 871292 Positive_regulation NR4A2 FOXA1 25249938 871294 Positive_regulation NR4A2 MSX1 18826576 1832832 Positive_regulation NR4A2 RASD1 21915321 2553243 Positive_regulation NR4A2 RASD1 21915321 2553266 Positive_regulation NR4A2 TNS1 25206509 2004919 Positive_regulation NR4A3 MAP2K6 21306619 332338 Positive_regulation NRARP DLL1 16144902 1323587 Positive_regulation NRARP HES1 19688092 2424210 Positive_regulation NRARP NOTCH1 22187650 1145435 Positive_regulation NRARP NOTCH1 22430492 1567837 Positive_regulation NRARP NOTCH1 22900075 2675060 Positive_regulation NRARP NOTCH1 PMC4070608 3206190 Positive_regulation NRARP NOTCH2 22187650 1145436 Positive_regulation NRARP NOTCH2 22430492 1567838 Positive_regulation NRARP NOTCH2 22900075 2675061 Positive_regulation NRARP NOTCH3 22187650 1145437 Positive_regulation NRARP NOTCH3 22430492 1567839 Positive_regulation NRARP NOTCH3 22900075 2675062 Positive_regulation NRARP NOTCH4 22187650 1145438 Positive_regulation NRARP NOTCH4 22430492 1567840 Positive_regulation NRARP NOTCH4 22900075 2675063 Positive_regulation NRAS CD14 20150966 1213534 Positive_regulation NRAS DGKI 25233099 3008240 Positive_regulation NRAS DGKI 25233099 3008247 Positive_regulation NRAS EFNB1 24868497 3179264 Positive_regulation NRAS EPHB2 17498287 999334 Positive_regulation NRAS EPHB2 18404483 3088059 Positive_regulation NRAS EPHB2 18463697 2289746 Positive_regulation NRAS EPHB2 19015320 1361560 Positive_regulation NRAS EPHB2 19652721 2422719 Positive_regulation NRAS EPHB2 19682393 1646630 Positive_regulation NRAS EPHB2 19826415 2127391 Positive_regulation NRAS EPHB2 21980390 2560148 Positive_regulation NRAS EPHB2 22319531 1067184 Positive_regulation NRAS EPHB2 22384111 2604101 Positive_regulation NRAS EPHB2 22567280 622878 Positive_regulation NRAS EPHB2 23060802 959312 Positive_regulation NRAS EPHB2 23617883 1867957 Positive_regulation NRAS EPHB2 23825558 2809649 Positive_regulation NRAS EPHB2 23908058 3227829 Positive_regulation NRAS EPHB2 23908058 3227830 Positive_regulation NRAS EPHB2 23908058 3227893 Positive_regulation NRAS EPHB2 24141185 1113553 Positive_regulation NRAS EPHB2 24330074 1482219 Positive_regulation NRAS EPHB2 24684778 1873622 Positive_regulation NRAS EPHB2 24743024 2189224 Positive_regulation NRAS EPHB2 24943349 365050 Positive_regulation NRAS EPHB2 24957684 2232044 Positive_regulation NRAS EPHB2 24994118 2194895 Positive_regulation NRAS EPHB2 25003010 3092920 Positive_regulation NRAS FOXA1 24073287 2853736 Positive_regulation NRAS FOXA1 24073287 2853742 Positive_regulation NRAS FOXO1 20375467 26998 Positive_regulation NRAS FOXO1 24265619 962919 Positive_regulation NRAS HBEGF 23888518 3185329 Positive_regulation NRAS LBP 20150966 1213535 Positive_regulation NRAS MAP2K6 17498287 999340 Positive_regulation NRAS MAP2K6 17892597 1645772 Positive_regulation NRAS MAP2K6 21072183 2481311 Positive_regulation NRAS MAP2K6 21307646 2223279 Positive_regulation NRAS MAP2K6 21307646 2223600 Positive_regulation NRAS MAP2K6 22384111 2604107 Positive_regulation NRAS MAP2K6 23060802 959318 Positive_regulation NRAS MAP2K6 23825558 2809655 Positive_regulation NRAS MAP2K6 23843700 2249776 Positive_regulation NRAS MAP2K6 23908058 3227841 Positive_regulation NRAS MAP2K6 23908058 3227842 Positive_regulation NRAS MAP2K6 23908058 3227899 Positive_regulation NRAS MAP2K6 24684778 1873628 Positive_regulation NRAS NGFR 25243118 199117 Positive_regulation NRAS PLAU 24971065 965308 Positive_regulation NRAS RASSF10 22500174 1067496 Positive_regulation NRAS TNF 24058780 1705542 Positive_regulation NRCAM EFNB1 24023801 2843602 Positive_regulation NRCAM EPHB2 24023801 2843572 Positive_regulation NRCAM EPHB2 24023801 2843575 Positive_regulation NRCAM EPHB2 24023801 2843606 Positive_regulation NRCAM EPHB2 24023801 2843647 Positive_regulation NRD1 HBEGF 19829704 2428764 Positive_regulation NRD1 TNF 22351606 778197 Positive_regulation NRF1 PGC 20491655 147797 Positive_regulation NRF1 PGC 22203837 832459 Positive_regulation NRF1 PGC 23431256 3154088 Positive_regulation NRF1 PGC 24098634 2858240 Positive_regulation NRF1 PGC 24288584 2227537 Positive_regulation NRF1 PGC 24624222 825352 Positive_regulation NRG1 EPHB2 24391468 2285207 Positive_regulation NRG1 MMP28 18778487 384765 Positive_regulation NRG1 MMP7 18778487 384780 Positive_regulation NRG2 EPHB2 24391468 2285211 Positive_regulation NRG3 EPHB2 24391468 2285215 Positive_regulation NRG4 EPHB2 24391468 2285183 Positive_regulation NRIP1 TLR7 21193034 158624 Positive_regulation NRK TNF 23255047 605215 Positive_regulation NRN1 EPHB2 23066017 1205252 Positive_regulation NRN1 EPHB2 24225021 388855 Positive_regulation NRP1 TNF 16277668 104605 Positive_regulation NRP1 TNF 23365490 1751428 Positive_regulation NRTN MAP2K6 21837281 2001955 Positive_regulation NRXN3 FOXQ1 23383267 2749800 Positive_regulation NRXN3 FOXQ1 23383267 2749801 Positive_regulation NRXN3 FOXQ1 23383267 2749807 Positive_regulation NSD1 TNF 24058709 2848647 Positive_regulation NT5E ALYREF 21249176 3050356 Positive_regulation NT5E BMP2 24018651 1675557 Positive_regulation NT5E CA2 18404474 3087787 Positive_regulation NT5E CD28 24493796 1574729 Positive_regulation NT5E DDX39B 21249176 3050354 Positive_regulation NT5E HIF1A 18404508 3089527 Positive_regulation NT5E HSPG2 18404437 3087433 Positive_regulation NT5E IL6 23125525 1225596 Positive_regulation NT5E IL6 24987392 913202 Positive_regulation NT5E IL7 24493796 1574731 Positive_regulation NT5E MCOLN1 18404474 3087786 Positive_regulation NT5E NGF 19173004 2404942 Positive_regulation NT5E NGF 25295627 1766795 Positive_regulation NT5E PRDX2 23737814 637537 Positive_regulation NT5E RHO 24945528 2981333 Positive_regulation NT5E SETD2 23423261 1709177 Positive_regulation NT5E SLC29A1 23437309 2756418 Positive_regulation NT5E SLC29A1 23437309 2756419 Positive_regulation NT5E SP1 23118504 1225315 Positive_regulation NT5E THOC1 21249176 3050355 Positive_regulation NT5E THOC2 21249176 3050358 Positive_regulation NT5E THOC3 21249176 3050357 Positive_regulation NT5E THOC5 21249176 3050359 Positive_regulation NT5E THOC6 21249176 3050360 Positive_regulation NT5E THOC7 21249176 3050361 Positive_regulation NT5E TNF 24133572 2867755 Positive_regulation NT5E TNF 24133572 2867758 Positive_regulation NTF3 CTGF 19214781 1478550 Positive_regulation NTF4 CTGF 19214781 1478551 Positive_regulation NTN1 EPHB2 22046354 2566902 Positive_regulation NTN1 UNC5B 21460185 1789347 Positive_regulation NTN1 UNC5B 24720832 1483001 Positive_regulation NTRK1 ANGPT1 19863762 1163715 Positive_regulation NTRK1 CTGF 19214781 1478552 Positive_regulation NTRK1 CTGF 22586581 722782 Positive_regulation NTRK1 CTGF 22586581 722791 Positive_regulation NTRK1 CTGF 23390502 2750819 Positive_regulation NTRK1 EPHB2 21501463 332671 Positive_regulation NTRK1 EPHB2 24667437 2938724 Positive_regulation NTRK1 MAP2K6 24667437 2938730 Positive_regulation NTRK1 NEDD9 19662191 178018 Positive_regulation NTRK1 NGFR 22236693 1652115 Positive_regulation NTRK1 NGFR 8253850 1446439 Positive_regulation NTRK1 NT5E 16549034 231885 Positive_regulation NTRK1 NT5E 22957106 2686661 Positive_regulation NTRK1 PLAT 21785728 1155332 Positive_regulation NTRK2 EPHB2 20156366 255295 Positive_regulation NTRK2 EPHB2 21779235 928017 Positive_regulation NTRK2 EPHB2 21849472 1793458 Positive_regulation NTRK2 NT5E 22957106 2686664 Positive_regulation NTRK2 NT5E 24300402 2247572 Positive_regulation NTRK2 SORL1 23977241 2839405 Positive_regulation NTRK2 TNF 21958434 1659848 Positive_regulation NTS EPHB2 21961726 261144 Positive_regulation NTS MMP28 25249538 2201831 Positive_regulation NTS MMP7 25249538 2201846 Positive_regulation NTS OXTR 21858088 2546117 Positive_regulation NTS OXTR 21858088 2546118 Positive_regulation NTS WNT7A 25170755 3003907 Positive_regulation NUAK2 TNF 19652946 732933 Positive_regulation NUP107 NES 9151683 1460077 Positive_regulation NUP107 NES 9151683 1460236 Positive_regulation NUP107 NES 9151683 1460313 Positive_regulation NUP133 NES 9151683 1460071 Positive_regulation NUP133 NES 9151683 1460230 Positive_regulation NUP133 NES 9151683 1460307 Positive_regulation NUP153 INPP4B 25126743 2998008 Positive_regulation NUP153 NES 9151683 1460080 Positive_regulation NUP153 NES 9151683 1460239 Positive_regulation NUP153 NES 9151683 1460316 Positive_regulation NUP153 TNF 21637744 2525869 Positive_regulation NUP155 NES 9151683 1460081 Positive_regulation NUP155 NES 9151683 1460240 Positive_regulation NUP155 NES 9151683 1460317 Positive_regulation NUP160 NES 9151683 1460072 Positive_regulation NUP160 NES 9151683 1460231 Positive_regulation NUP160 NES 9151683 1460308 Positive_regulation NUP188 NES 9151683 1460070 Positive_regulation NUP188 NES 9151683 1460229 Positive_regulation NUP188 NES 9151683 1460306 Positive_regulation NUP205 NES 9151683 1460073 Positive_regulation NUP205 NES 9151683 1460232 Positive_regulation NUP205 NES 9151683 1460309 Positive_regulation NUP210 INPP4B 25126743 2998007 Positive_regulation NUP210 NES 9151683 1460079 Positive_regulation NUP210 NES 9151683 1460238 Positive_regulation NUP210 NES 9151683 1460315 Positive_regulation NUP210 TNF 21637744 2525856 Positive_regulation NUP214 INPP4B 25126743 2998009 Positive_regulation NUP214 NES 9151683 1460082 Positive_regulation NUP214 NES 9151683 1460241 Positive_regulation NUP214 NES 9151683 1460318 Positive_regulation NUP214 TNF 21637744 2525871 Positive_regulation NUP35 NES 9151683 1460076 Positive_regulation NUP35 NES 9151683 1460235 Positive_regulation NUP35 NES 9151683 1460312 Positive_regulation NUP37 NES 9151683 1460078 Positive_regulation NUP37 NES 9151683 1460237 Positive_regulation NUP37 NES 9151683 1460314 Positive_regulation NUP43 CTGF 19852794 1227775 Positive_regulation NUP43 FAS 16818723 1330943 Positive_regulation NUP43 MAP2K6 22864984 616770 Positive_regulation NUP43 MMP28 23688423 313742 Positive_regulation NUP43 MMP28 23688423 314207 Positive_regulation NUP43 MMP7 23688423 313757 Positive_regulation NUP43 MMP7 23688423 314223 Positive_regulation NUP43 NES 9151683 1460074 Positive_regulation NUP43 NES 9151683 1460233 Positive_regulation NUP43 NES 9151683 1460310 Positive_regulation NUP43 TNF 21867555 1659571 Positive_regulation NUP43 TNF 21867555 1659572 Positive_regulation NUP43 TNF 23688423 314202 Positive_regulation NUP43 TNF 24069158 2851532 Positive_regulation NUP43 TNF 24215724 538191 Positive_regulation NUP50 EPHB2 22028962 1686701 Positive_regulation NUP50 EPHB2 23455463 1102837 Positive_regulation NUP50 NES 9151683 1460083 Positive_regulation NUP50 NES 9151683 1460242 Positive_regulation NUP50 NES 9151683 1460319 Positive_regulation NUP54 NES 9151683 1460069 Positive_regulation NUP54 NES 9151683 1460228 Positive_regulation NUP54 NES 9151683 1460305 Positive_regulation NUP62 INPP4B 25126743 2998010 Positive_regulation NUP62 NES 9151683 1460084 Positive_regulation NUP62 NES 9151683 1460243 Positive_regulation NUP62 NES 9151683 1460320 Positive_regulation NUP62 TNF 21637744 2525873 Positive_regulation NUP85 NES 9151683 1460087 Positive_regulation NUP85 NES 9151683 1460246 Positive_regulation NUP85 NES 9151683 1460323 Positive_regulation NUP88 NES 9151683 1460085 Positive_regulation NUP88 NES 9151683 1460244 Positive_regulation NUP88 NES 9151683 1460321 Positive_regulation NUP93 NES 9151683 1460075 Positive_regulation NUP93 NES 9151683 1460234 Positive_regulation NUP93 NES 9151683 1460311 Positive_regulation NUP98 NES 20375145 1775640 Positive_regulation NUP98 NES 9151683 1460086 Positive_regulation NUP98 NES 9151683 1460245 Positive_regulation NUP98 NES 9151683 1460322 Positive_regulation OAS1 EPHB2 22279582 2590798 Positive_regulation OAS1 TLR7 23824215 2808919 Positive_regulation OAS2 EPHB2 22279582 2590799 Positive_regulation OAS2 TLR7 23824215 2808920 Positive_regulation OAS3 EPHB2 22279582 2590800 Positive_regulation OAS3 TLR7 23824215 2808921 Positive_regulation OASL IFN1@ 23874199 3063147 Positive_regulation OATP1 PDZK1 24728453 2952053 Positive_regulation OATP1 PDZK1 24728453 2952054 Positive_regulation OATP1 PDZK1 24728453 2952060 Positive_regulation OATP1 PDZK1 24728453 2952065 Positive_regulation OCLN ANGPT1 23894369 2824431 Positive_regulation OCLN C12orf75 9015310 1459008 Positive_regulation OCLN CLDN10 22361748 555045 Positive_regulation OCLN PLAT 23565108 935271 Positive_regulation OCLN TNF 20351069 1374158 Positive_regulation OCLN TNF 20351069 1374159 Positive_regulation OCLN TNF 20351069 1374160 Positive_regulation OCLN TNF 20351069 1374164 Positive_regulation OCLN TNF 20693346 716063 Positive_regulation OCLN TNF 21853060 2542974 Positive_regulation OCLN TNF 23924897 1817664 Positive_regulation OCLN TNF 23924897 1817693 Positive_regulation OCLN TNF 23924897 1817697 Positive_regulation OCLN TNF 24155670 1061993 Positive_regulation OCLN TNF 25132736 1760507 Positive_regulation ODC1 EPHB2 18294404 250792 Positive_regulation ODF2 NES 15251038 277807 Positive_regulation OFD1 NES 15251038 277782 Positive_regulation OGG1 PGC 24988481 2986297 Positive_regulation OIP5 TNF 24516558 2921117 Positive_regulation OLFM4 CSF3 24495253 1482919 Positive_regulation OLFM4 NOTCH1 PMC4212306 3206353 Positive_regulation OLFM4 NOTCH2 PMC4212306 3206354 Positive_regulation OLFM4 NOTCH3 PMC4212306 3206355 Positive_regulation OLFM4 NOTCH4 PMC4212306 3206356 Positive_regulation OLFM4 SMARCA4 25010414 2360360 Positive_regulation OLFM4 TNF PMC4212306 3206352 Positive_regulation OLFM4 TNF PMC4212306 3206464 Positive_regulation OLR1 TLR7 14699082 1530493 Positive_regulation OLR1 TNF 21805404 511719 Positive_regulation OLR1 TNF 22879901 2672902 Positive_regulation OLR1 TNF 22879901 2672905 Positive_regulation OLR1 TNF 22879901 2672907 Positive_regulation OLR1 TNF 22879901 2672908 Positive_regulation OLR1 TNF 24217965 1606826 Positive_regulation OLR1 TNF 24829918 190682 Positive_regulation OLR1 TNF 25250731 3009902 Positive_regulation OLR1 TNF 25250731 3009903 Positive_regulation OLR1 TNF 25388834 1485947 Positive_regulation OLR1 TNF 25598757 1064869 Positive_regulation OLR1 TNFSF10 24466325 2914330 Positive_regulation OMA1 RNASE1 25261697 993107 Positive_regulation OPA1 ALOX5 23991239 2372055 Positive_regulation OPA1 CLU 23164821 1901071 Positive_regulation OPA1 IL1B 11132773 1737347 Positive_regulation OPA1 TLR7 15804356 3104572 Positive_regulation OPA1 TLR7 22691272 126315 Positive_regulation OPA1 TNF 10408703 414851 Positive_regulation OPA1 TNF 11132773 1737346 Positive_regulation OPA1 TNF 18410682 110449 Positive_regulation OPA1 TNF 18410682 110491 Positive_regulation OPA1 TNF 21904602 2550390 Positive_regulation OPA1 TNF 22691272 126314 Positive_regulation OPA1 TNF 22723832 2654735 Positive_regulation OPA1 TNF 22723832 2654767 Positive_regulation OPA1 TNF 24300561 2247629 Positive_regulation OPN1LW CAPN8 21655322 2527864 Positive_regulation OPN1LW RIC3 15824136 1319952 Positive_regulation OPN1LW TNF 21857970 2544491 Positive_regulation OPN1MW ID1 24204703 2874092 Positive_regulation OPN1SW TCN1 24735601 1667964 Positive_regulation OPTN TNF 20388642 1033143 Positive_regulation OPTN TNF 22509108 1914197 Positive_regulation ORC1 ACSS1 16984967 2022615 Positive_regulation ORC2 ACSS1 16984967 2022618 Positive_regulation ORC3 ACSS1 16984967 2022621 Positive_regulation ORC4 ACSS1 16984967 2022624 Positive_regulation ORC5 ACSS1 16984967 2022627 Positive_regulation ORC6 ACSS1 16984967 2022612 Positive_regulation ORM1 TF 2991301 1424923 Positive_regulation ORM2 TF 2991301 1424924 Positive_regulation OSBPL5 TNF 21931534 2277166 Positive_regulation OSCAR TNF 23146195 127232 Positive_regulation OSM ADAMTS1 20645923 147919 Positive_regulation OSM PLAU PMC2834060 134533 Positive_regulation OSM S100A7 25010647 2987988 Positive_regulation OSM TGM2 23765377 1680849 Positive_regulation OSM TLR7 23483986 2764924 Positive_regulation OSM TLR7 24307759 1755450 Positive_regulation OSM TNF 24175110 1053777 Positive_regulation OSR1 CDH1 25226030 3007622 Positive_regulation OSR1 COMT 19228412 143278 Positive_regulation OSR1 EPC1 25226030 3007639 Positive_regulation OSR1 EPC2 25226030 3007640 Positive_regulation OSR1 EYA1 23560233 85990 Positive_regulation OSR1 INS 21909387 2551852 Positive_regulation OSR1 JUN 24349499 2898361 Positive_regulation OSR1 NES 24349499 2898368 Positive_regulation OSR1 PAX2 23560233 85991 Positive_regulation OSR1 PDC 20955552 403376 Positive_regulation OSR1 PDC 20955552 403381 Positive_regulation OSR1 SETD2 18404475 3087793 Positive_regulation OSR1 WNK1 24393035 152281 Positive_regulation OSR1 WNK2 24393035 152282 Positive_regulation OSR1 WNK3 24393035 152283 Positive_regulation OSR1 WNK4 24039833 2844893 Positive_regulation OSR1 WNK4 24393035 152284 Positive_regulation OSR2 NES 24349499 2898367 Positive_regulation OXA1L ABCG2 20628378 435660 Positive_regulation OXA1L CCND1 25289101 2169773 Positive_regulation OXA1L FAS 24691448 2947765 Positive_regulation OXA1L S100B 24725992 3169960 Positive_regulation OXA1L TNF 17183656 2373751 Positive_regulation OXA1L WNT7A 23862015 169996 Positive_regulation OXA1L WNT7A 23862015 169997 Positive_regulation OXA1L WNT7A 23862015 169998 Positive_regulation OXA1L WNT7A 23862015 169999 Positive_regulation OXA1L WNT7A 23862015 170000 Positive_regulation OXA1L WNT7A 23862015 170001 Positive_regulation OXA1L WNT7A 23862015 170002 Positive_regulation OXA1L WNT7A 23862015 170030 Positive_regulation OXA1L WNT7A 23862015 170031 Positive_regulation OXA1L WNT7A 23862015 170032 Positive_regulation OXA1L WNT7A 23862015 170033 Positive_regulation OXA1L WNT7A 23862015 170047 Positive_regulation OXA1L WNT7A 23862015 170058 Positive_regulation OXA1L WNT7A 23862015 170059 Positive_regulation OXA1L WNT7A 23862015 170067 Positive_regulation OXA1L WNT7A 23862015 170068 Positive_regulation OXA1L WNT7A 23862015 170073 Positive_regulation OXA1L WNT7A 23862015 170080 Positive_regulation OXT OXTR 25049471 136103 Positive_regulation OXT TMEM100 23335873 937665 Positive_regulation OXT TMEM156 23335873 937683 Positive_regulation OXT TMEM211 23335873 937763 Positive_regulation OXT TMEM213 23335873 937700 Positive_regulation OXTR ADRBK1 22952466 877094 Positive_regulation OXTR AVPR2 19549333 659239 Positive_regulation OXTR ESR1 22375116 897460 Positive_regulation OXTR ESR1 23050969 89631 Positive_regulation OXTR ESR1 23966904 938256 Positive_regulation OXTR HSPG2 25132821 965783 Positive_regulation OXTR IL1A PMC2442803 1049669 Positive_regulation OXTR IL6 23205502 1479161 Positive_regulation OXTR IL6 23390521 2750848 Positive_regulation OXTR IL6 23390521 2750853 Positive_regulation OXTR OXT 25049471 136105 Positive_regulation OXTR PGF 25049471 136106 Positive_regulation OXTR PRDX2 23727821 1967990 Positive_regulation OXTR PRDX2 23727821 1967999 Positive_regulation OXTR PRDX2 23727821 1968000 Positive_regulation OXTR PRDX2 23727821 1968002 Positive_regulation OXTR PRDX2 23727821 1968003 Positive_regulation P2RX1 F2R 23986721 962077 Positive_regulation P2RX4 TNF 22547202 3090956 Positive_regulation P2RX7 EPHB2 22163032 2577873 Positive_regulation P2RX7 FAS 23618909 561681 Positive_regulation P2RX7 TLR7 19212823 3090560 Positive_regulation P2RY1 EPHB2 21505453 436704 Positive_regulation P2RY1 F2R 23986721 962080 Positive_regulation P2RY1 TNF 18404425 3087176 Positive_regulation P2RY12 F2R 23986721 962066 Positive_regulation P2RY12 TNF 24191147 867705 Positive_regulation P2RY2 EPHB2 18404483 3087964 Positive_regulation P2RY2 MAP2K6 18404483 3087971 Positive_regulation P2RY2 MMP28 25238333 2201355 Positive_regulation P2RY2 MMP7 25238333 2201370 Positive_regulation P2RY6 TNF 25360548 3020839 Positive_regulation P4HB TNF 8691130 1598118 Positive_regulation PABPC1 LAMB3 22160594 1798619 Positive_regulation PABPC1 TNF 23688423 314167 Positive_regulation PABPC1 TNF 9382882 1602113 Positive_regulation PACS2 TNFSF10 24978043 2985497 Positive_regulation PACSIN2 PGC 25610371 872922 Positive_regulation PADI2 PADI3 23110523 266777 Positive_regulation PADI3 NFYA 18923650 2397768 Positive_regulation PADI3 NFYB 18923650 2397769 Positive_regulation PADI3 NFYC 18923650 2397770 Positive_regulation PADI3 PADI2 23110523 266776 Positive_regulation PADI3 SP1 18923650 2397766 Positive_regulation PADI3 SP3 18923650 2397767 Positive_regulation PADI4 TNF 20222985 481502 Positive_regulation PAEP MMP28 25343714 3019780 Positive_regulation PAEP MMP7 25343714 3019795 Positive_regulation PAEP RNASE1 21904456 1136776 Positive_regulation PAEP TNF 16569263 105668 Positive_regulation PAEP TNF 16569263 105669 Positive_regulation PAEP TNF 24088372 2233548 Positive_regulation PAEP ZFP57 20460361 1499323 Positive_regulation PAF1 ALOX5 8666909 1597095 Positive_regulation PAF1 F2R PMC2756345 496004 Positive_regulation PAF1 GPR115 21079759 3049657 Positive_regulation PAF1 GPR115 25375862 3023580 Positive_regulation PAF1 GPR132 21079759 3049646 Positive_regulation PAF1 GPR132 25375862 3023569 Positive_regulation PAF1 GPR87 21079759 3049726 Positive_regulation PAF1 GPR87 25375862 3023649 Positive_regulation PAF1 LPCAT1 21079759 3049446 Positive_regulation PAF1 LPCAT1 25415055 177548 Positive_regulation PAF1 TNF 18475680 1745377 Positive_regulation PAF1 TNF 18475682 1745390 Positive_regulation PAF1 TNF 18475742 1746299 Positive_regulation PAF1 TNF 21082032 2482399 Positive_regulation PAF1 TNF 2137857 1562737 Positive_regulation PAF1 TNF 2137857 1562749 Positive_regulation PAF1 TNF 21860543 1749386 Positive_regulation PAF1 TNF 2659725 1577676 Positive_regulation PAF1 TNF 3049910 1579727 Positive_regulation PAF1 TNF 3049910 1579728 Positive_regulation PAF1 TNF 3049910 1579729 Positive_regulation PAF1 TNF 3049910 1579730 Positive_regulation PAF1 TNF 3049910 1579776 Positive_regulation PAF1 TNF 3049910 1579788 Positive_regulation PAF1 TNF 3049910 1579798 Positive_regulation PAF1 TNF 3049910 1579803 Positive_regulation PAF1 TNF 3119758 1580123 Positive_regulation PAF1 TNF 3119758 1580124 Positive_regulation PAF1 TNF 3119758 1580125 Positive_regulation PAF1 TNF 3119758 1580126 Positive_regulation PAF1 TNF 3119758 1580127 Positive_regulation PAF1 TNF 3119758 1580170 Positive_regulation PAF1 TNF 7516414 1589276 Positive_regulation PAF1 TNF 7516414 1589281 Positive_regulation PAF1 TNF 7516414 1589301 Positive_regulation PAF1 TNF 7516414 1589306 Positive_regulation PAFAH1B1 CAPN8 19734909 1960735 Positive_regulation PAFAH1B1 CAPN8 19734909 1960763 Positive_regulation PAFAH1B1 MAP2K6 22164275 2580233 Positive_regulation PAFAH1B1 MAP2K6 22164275 2580234 Positive_regulation PAFAH1B1 MAP2K6 22164275 2580235 Positive_regulation PAFAH1B1 MAP2K6 22164275 2580247 Positive_regulation PAFAH1B1 MAP2K6 22164275 2580254 Positive_regulation PAFAH1B1 MAP2K6 22164275 2580261 Positive_regulation PAFAH1B1 MAP2K6 22164275 2580268 Positive_regulation PAFAH1B1 NES 15251038 277808 Positive_regulation PAGR1 F2R 23300803 2736042 Positive_regulation PAH ANGPT1 19737862 1556177 Positive_regulation PAH STK39 21533110 2514451 Positive_regulation PAIP1 LAMB3 22160594 1798610 Positive_regulation PAIP1 TNF 23688423 314164 Positive_regulation PAIP1 TNF 9382882 1602110 Positive_regulation PAK1 ABCA12 23829168 269352 Positive_regulation PAK1 ABCA4 23829168 269358 Positive_regulation PAK1 EPHB2 23497290 1867532 Positive_regulation PAK1 TNF 19298660 352669 Positive_regulation PAK1 TNF 19298660 352728 Positive_regulation PAK1 TNF 19298660 352729 Positive_regulation PAK1 TNF 19298660 352777 Positive_regulation PAK2 EPHB2 23497290 1867533 Positive_regulation PAK2 FAS 9362518 1464844 Positive_regulation PAK2 MMP28 20111678 1089117 Positive_regulation PAK2 MMP28 20111678 1089205 Positive_regulation PAK2 MMP7 20111678 1089132 Positive_regulation PAK2 MMP7 20111678 1089220 Positive_regulation PAK2 SLC6A2 23864709 1817033 Positive_regulation PAK2 SLC6A2 23864709 1817034 Positive_regulation PAK2 SLC6A2 23864709 1817038 Positive_regulation PAK2 TNF 7519620 1436180 Positive_regulation PAK3 EPHB2 23497290 1867534 Positive_regulation PAK4 EPHB2 23497290 1867525 Positive_regulation PAK6 EPHB2 23497290 1867526 Positive_regulation PAK6 MAP2K6 24352566 606900 Positive_regulation PAK7 EPHB2 23497290 1867524 Positive_regulation PALLD EPHB2 22216253 2585059 Positive_regulation PALLD EPHB2 22216253 2585067 Positive_regulation PALLD MAP2K6 22216253 2585065 Positive_regulation PALLD MAP2K6 22216253 2585073 Positive_regulation PAM EPHB2 21042538 2479710 Positive_regulation PAM EPHB2 22783258 902321 Positive_regulation PAM TLR7 12975352 1297219 Positive_regulation PAM TLR7 20808895 3048443 Positive_regulation PAM TLR7 22530722 3210212 Positive_regulation PAM TLR7 22530722 3210412 Positive_regulation PAM TNF 18195069 1548435 Positive_regulation PAM TNF 19966777 1960925 Positive_regulation PAM TNF 20051129 3110246 Positive_regulation PAM TNF 21998707 2562136 Positive_regulation PAM TNF 24205328 2875993 Positive_regulation PAM TNF 24205328 2876075 Positive_regulation PANX1 TNF 25301274 1763021 Positive_regulation PAPPA TNF 22553932 732137 Positive_regulation PAPPA TNF 22997483 1750579 Positive_regulation PAPPA TNF 22997483 1750580 Positive_regulation PAPPA TNF 22997483 1750582 Positive_regulation PAPPA TNF 22997483 1750583 Positive_regulation PAPPA TNF 22997483 1750592 Positive_regulation PAPPA TNF 22997483 1750595 Positive_regulation PAPPA2 TNF 21496272 3101075 Positive_regulation PAPSS1 EPHB2 22312298 1094944 Positive_regulation PAPSS1 TNF 24672735 3151538 Positive_regulation PARK10 PGC 22916173 2680144 Positive_regulation PARK11 PGC 22916173 2680145 Positive_regulation PARK12 PGC 22916173 2680146 Positive_regulation PARK16 PGC 22916173 2680147 Positive_regulation PARK2 PGC 22916173 2680148 Positive_regulation PARK2 TNF 22523581 2620414 Positive_regulation PARK2 TNF 22925731 357274 Positive_regulation PARK3 PGC 22916173 2680149 Positive_regulation PARK7 EPHB2 20386724 2271416 Positive_regulation PARK7 PGC 22916173 2680143 Positive_regulation PARK7 TNF 22523581 2620392 Positive_regulation PARK7 TNF 22925731 357273 Positive_regulation PARN RNASE1 25200086 2104764 Positive_regulation PARN RNASE7 25200086 2104772 Positive_regulation PARP1 CAPN8 21176168 527024 Positive_regulation PARP1 CAPN8 22666585 2009586 Positive_regulation PARP1 CAPN8 22666585 2009621 Positive_regulation PARP1 CAPN8 23744356 562261 Positive_regulation PARP1 CCND1 20531415 434972 Positive_regulation PARP1 EPHB2 22035226 527797 Positive_regulation PARP1 EPHB2 22035226 527931 Positive_regulation PARP1 EPHB2 23209876 3131754 Positive_regulation PARP1 EPHB2 23209876 3131755 Positive_regulation PARP1 EPHB2 23758320 151616 Positive_regulation PARP1 EPHB2 24145797 786322 Positive_regulation PARP1 EPHB2 24145797 786324 Positive_regulation PARP1 EPHB2 24586933 2928427 Positive_regulation PARP1 EPHB2 24874851 223013 Positive_regulation PARP1 EPHB2 25089620 2994543 Positive_regulation PARP1 EPHB2 25089620 2994544 Positive_regulation PARP1 EPHB2 25089620 2994564 Positive_regulation PARP1 FAS 15188008 424546 Positive_regulation PARP1 FAS 21379337 3051300 Positive_regulation PARP1 FAS 23577779 1480351 Positive_regulation PARP1 FAS 23577779 1480352 Positive_regulation PARP1 FAS 23577779 1480558 Positive_regulation PARP1 FOLR1 20069122 1671682 Positive_regulation PARP1 IFI27 21424700 1148143 Positive_regulation PARP1 LBP 24595452 2931333 Positive_regulation PARP1 MIP 21347304 2503587 Positive_regulation PARP1 MMP28 19907806 512429 Positive_regulation PARP1 MMP28 24116286 204338 Positive_regulation PARP1 MMP7 19907806 512444 Positive_regulation PARP1 MMP7 24116286 204353 Positive_regulation PARP1 PECAM1 10725328 1256533 Positive_regulation PARP1 PECAM1 10725328 1256552 Positive_regulation PARP1 TCN1 23936501 2831134 Positive_regulation PARP1 TNF 15642133 102118 Positive_regulation PARP1 TNF 16043520 1536941 Positive_regulation PARP1 TNF 19060926 2124099 Positive_regulation PARP1 TNF 20109177 118175 Positive_regulation PARP1 TNF 23202463 3221524 Positive_regulation PARP1 TNF 23593410 2781192 Positive_regulation PARP1 TNF 23603982 17471 Positive_regulation PARP1 TNF 23760205 605913 Positive_regulation PARP1 TNF 23760205 605914 Positive_regulation PARP1 TNF 23760205 605918 Positive_regulation PARP1 TNF 23894414 2824519 Positive_regulation PARP1 TNF 24363881 1764621 Positive_regulation PARP1 TNFSF10 20113484 1853248 Positive_regulation PARP1 TNFSF10 20661477 2456817 Positive_regulation PARP1 TNFSF10 20661477 2456868 Positive_regulation PARP1 TNFSF10 22179661 1140762 Positive_regulation PARP1 TNFSF10 22179661 1140763 Positive_regulation PARP1 TNFSF10 23517112 268077 Positive_regulation PARP1 TNFSF10 24147007 2869157 Positive_regulation PARP1 TNFSF10 24147007 2869207 Positive_regulation PARP1 TNFSF10 24204567 2873042 Positive_regulation PARP1 TNFSF10 24566141 1124118 Positive_regulation PARP1 TNFSF10 25191654 861461 Positive_regulation PARP1 TNFSF10 9105050 1459785 Positive_regulation PARP10 CCND1 20531415 434962 Positive_regulation PARP10 FAS 15188008 424541 Positive_regulation PARP10 FAS 21379337 3051295 Positive_regulation PARP10 FAS 23577779 1480341 Positive_regulation PARP10 FAS 23577779 1480342 Positive_regulation PARP10 FAS 23577779 1480488 Positive_regulation PARP10 FOLR1 20069122 1671657 Positive_regulation PARP10 IFI27 21424700 1148128 Positive_regulation PARP10 MIP 21347304 2503582 Positive_regulation PARP10 MMP28 19907806 512319 Positive_regulation PARP10 MMP7 19907806 512334 Positive_regulation PARP10 TNF 15642133 102108 Positive_regulation PARP10 TNF 20109177 118160 Positive_regulation PARP10 TNF 23202463 3221519 Positive_regulation PARP10 TNF 23593410 2781187 Positive_regulation PARP10 TNF 23603982 17466 Positive_regulation PARP10 TNFSF10 20113484 1853243 Positive_regulation PARP10 TNFSF10 20661477 2456812 Positive_regulation PARP10 TNFSF10 20661477 2456863 Positive_regulation PARP10 TNFSF10 23517112 268072 Positive_regulation PARP10 TNFSF10 24204567 2873037 Positive_regulation PARP10 TNFSF10 24566141 1124113 Positive_regulation PARP10 TNFSF10 25191654 861456 Positive_regulation PARP10 TNFSF10 9105050 1459780 Positive_regulation PARP11 CCND1 20531415 434930 Positive_regulation PARP11 FAS 15188008 424538 Positive_regulation PARP11 FAS 21379337 3051292 Positive_regulation PARP11 FAS 23577779 1480334 Positive_regulation PARP11 FAS 23577779 1480335 Positive_regulation PARP11 FAS 23577779 1480445 Positive_regulation PARP11 FOLR1 20069122 1671642 Positive_regulation PARP11 IFI27 21424700 1148119 Positive_regulation PARP11 MIP 21347304 2503578 Positive_regulation PARP11 MMP28 19907806 512253 Positive_regulation PARP11 MMP7 19907806 512268 Positive_regulation PARP11 TNF 15642133 102102 Positive_regulation PARP11 TNF 20109177 118151 Positive_regulation PARP11 TNF 23202463 3221516 Positive_regulation PARP11 TNF 23593410 2781175 Positive_regulation PARP11 TNF 23603982 17463 Positive_regulation PARP11 TNFSF10 20113484 1853225 Positive_regulation PARP11 TNFSF10 20661477 2456793 Positive_regulation PARP11 TNFSF10 20661477 2456860 Positive_regulation PARP11 TNFSF10 23517112 268069 Positive_regulation PARP11 TNFSF10 24204567 2873034 Positive_regulation PARP11 TNFSF10 24566141 1124110 Positive_regulation PARP11 TNFSF10 25191654 861453 Positive_regulation PARP11 TNFSF10 9105050 1459777 Positive_regulation PARP12 CCND1 20531415 434945 Positive_regulation PARP12 FAS 15188008 424539 Positive_regulation PARP12 FAS 21379337 3051293 Positive_regulation PARP12 FAS 23577779 1480337 Positive_regulation PARP12 FAS 23577779 1480338 Positive_regulation PARP12 FAS 23577779 1480460 Positive_regulation PARP12 FOLR1 20069122 1671647 Positive_regulation PARP12 IFI27 21424700 1148122 Positive_regulation PARP12 MIP 21347304 2503580 Positive_regulation PARP12 MMP28 19907806 512275 Positive_regulation PARP12 MMP7 19907806 512290 Positive_regulation PARP12 TNF 15642133 102104 Positive_regulation PARP12 TNF 20109177 118154 Positive_regulation PARP12 TNF 23202463 3221517 Positive_regulation PARP12 TNF 23593410 2781185 Positive_regulation PARP12 TNF 23603982 17464 Positive_regulation PARP12 TNFSF10 20113484 1853241 Positive_regulation PARP12 TNFSF10 20661477 2456810 Positive_regulation PARP12 TNFSF10 20661477 2456861 Positive_regulation PARP12 TNFSF10 23517112 268070 Positive_regulation PARP12 TNFSF10 24204567 2873035 Positive_regulation PARP12 TNFSF10 24566141 1124111 Positive_regulation PARP12 TNFSF10 25191654 861454 Positive_regulation PARP12 TNFSF10 9105050 1459778 Positive_regulation PARP14 CCND1 20531415 434980 Positive_regulation PARP14 FAS 15188008 424550 Positive_regulation PARP14 FAS 21379337 3051304 Positive_regulation PARP14 FAS 23577779 1480359 Positive_regulation PARP14 FAS 23577779 1480360 Positive_regulation PARP14 FAS 23577779 1480614 Positive_regulation PARP14 FOLR1 20069122 1671702 Positive_regulation PARP14 IFI27 21424700 1148155 Positive_regulation PARP14 MIP 21347304 2503591 Positive_regulation PARP14 MMP28 19907806 512517 Positive_regulation PARP14 MMP7 19907806 512532 Positive_regulation PARP14 TNF 15642133 102126 Positive_regulation PARP14 TNF 20109177 118187 Positive_regulation PARP14 TNF 23202463 3221528 Positive_regulation PARP14 TNF 23593410 2781196 Positive_regulation PARP14 TNF 23603982 17475 Positive_regulation PARP14 TNFSF10 20113484 1853252 Positive_regulation PARP14 TNFSF10 20661477 2456821 Positive_regulation PARP14 TNFSF10 20661477 2456872 Positive_regulation PARP14 TNFSF10 23517112 268081 Positive_regulation PARP14 TNFSF10 24204567 2873046 Positive_regulation PARP14 TNFSF10 24566141 1124122 Positive_regulation PARP14 TNFSF10 25191654 861465 Positive_regulation PARP14 TNFSF10 9105050 1459789 Positive_regulation PARP15 CCND1 20531415 434968 Positive_regulation PARP15 FAS 15188008 424544 Positive_regulation PARP15 FAS 21379337 3051298 Positive_regulation PARP15 FAS 23577779 1480347 Positive_regulation PARP15 FAS 23577779 1480348 Positive_regulation PARP15 FAS 23577779 1480530 Positive_regulation PARP15 FOLR1 20069122 1671672 Positive_regulation PARP15 IFI27 21424700 1148137 Positive_regulation PARP15 MIP 21347304 2503585 Positive_regulation PARP15 MMP28 19907806 512385 Positive_regulation PARP15 MMP7 19907806 512400 Positive_regulation PARP15 TNF 15642133 102114 Positive_regulation PARP15 TNF 20109177 118169 Positive_regulation PARP15 TNF 23202463 3221522 Positive_regulation PARP15 TNF 23593410 2781190 Positive_regulation PARP15 TNF 23603982 17469 Positive_regulation PARP15 TNFSF10 20113484 1853246 Positive_regulation PARP15 TNFSF10 20661477 2456815 Positive_regulation PARP15 TNFSF10 20661477 2456866 Positive_regulation PARP15 TNFSF10 23517112 268075 Positive_regulation PARP15 TNFSF10 24204567 2873040 Positive_regulation PARP15 TNFSF10 24566141 1124116 Positive_regulation PARP15 TNFSF10 25191654 861459 Positive_regulation PARP15 TNFSF10 9105050 1459783 Positive_regulation PARP16 CCND1 20531415 434964 Positive_regulation PARP16 FAS 15188008 424542 Positive_regulation PARP16 FAS 21379337 3051296 Positive_regulation PARP16 FAS 23577779 1480343 Positive_regulation PARP16 FAS 23577779 1480344 Positive_regulation PARP16 FAS 23577779 1480502 Positive_regulation PARP16 FOLR1 20069122 1671662 Positive_regulation PARP16 IFI27 21424700 1148131 Positive_regulation PARP16 MIP 21347304 2503583 Positive_regulation PARP16 MMP28 19907806 512341 Positive_regulation PARP16 MMP7 19907806 512356 Positive_regulation PARP16 TNF 15642133 102110 Positive_regulation PARP16 TNF 20109177 118163 Positive_regulation PARP16 TNF 23202463 3221520 Positive_regulation PARP16 TNF 23593410 2781188 Positive_regulation PARP16 TNF 23603982 17467 Positive_regulation PARP16 TNFSF10 20113484 1853244 Positive_regulation PARP16 TNFSF10 20661477 2456813 Positive_regulation PARP16 TNFSF10 20661477 2456864 Positive_regulation PARP16 TNFSF10 23517112 268073 Positive_regulation PARP16 TNFSF10 24204567 2873038 Positive_regulation PARP16 TNFSF10 24566141 1124114 Positive_regulation PARP16 TNFSF10 25191654 861457 Positive_regulation PARP16 TNFSF10 9105050 1459781 Positive_regulation PARP2 CCND1 20531415 434976 Positive_regulation PARP2 FAS 15188008 424548 Positive_regulation PARP2 FAS 21379337 3051302 Positive_regulation PARP2 FAS 23577779 1480355 Positive_regulation PARP2 FAS 23577779 1480356 Positive_regulation PARP2 FAS 23577779 1480586 Positive_regulation PARP2 FOLR1 20069122 1671692 Positive_regulation PARP2 IFI27 21424700 1148149 Positive_regulation PARP2 MIP 21347304 2503589 Positive_regulation PARP2 MMP28 19907806 512473 Positive_regulation PARP2 MMP7 19907806 512488 Positive_regulation PARP2 TNF 15642133 102122 Positive_regulation PARP2 TNF 20109177 118181 Positive_regulation PARP2 TNF 23202463 3221526 Positive_regulation PARP2 TNF 23593410 2781194 Positive_regulation PARP2 TNF 23603982 17473 Positive_regulation PARP2 TNFSF10 20113484 1853250 Positive_regulation PARP2 TNFSF10 20661477 2456819 Positive_regulation PARP2 TNFSF10 20661477 2456870 Positive_regulation PARP2 TNFSF10 23517112 268079 Positive_regulation PARP2 TNFSF10 24204567 2873044 Positive_regulation PARP2 TNFSF10 24566141 1124120 Positive_regulation PARP2 TNFSF10 25191654 861463 Positive_regulation PARP2 TNFSF10 9105050 1459787 Positive_regulation PARP3 CCND1 20531415 434978 Positive_regulation PARP3 FAS 15188008 424549 Positive_regulation PARP3 FAS 21379337 3051303 Positive_regulation PARP3 FAS 23577779 1480357 Positive_regulation PARP3 FAS 23577779 1480358 Positive_regulation PARP3 FAS 23577779 1480600 Positive_regulation PARP3 FOLR1 20069122 1671697 Positive_regulation PARP3 IFI27 21424700 1148152 Positive_regulation PARP3 MIP 21347304 2503590 Positive_regulation PARP3 MMP28 19907806 512495 Positive_regulation PARP3 MMP7 19907806 512510 Positive_regulation PARP3 TNF 15642133 102124 Positive_regulation PARP3 TNF 20109177 118184 Positive_regulation PARP3 TNF 23202463 3221527 Positive_regulation PARP3 TNF 23593410 2781195 Positive_regulation PARP3 TNF 23603982 17474 Positive_regulation PARP3 TNFSF10 20113484 1853251 Positive_regulation PARP3 TNFSF10 20661477 2456820 Positive_regulation PARP3 TNFSF10 20661477 2456871 Positive_regulation PARP3 TNFSF10 23517112 268080 Positive_regulation PARP3 TNFSF10 24204567 2873045 Positive_regulation PARP3 TNFSF10 24566141 1124121 Positive_regulation PARP3 TNFSF10 25191654 861464 Positive_regulation PARP3 TNFSF10 9105050 1459788 Positive_regulation PARP4 CCND1 20531415 434974 Positive_regulation PARP4 FAS 15188008 424547 Positive_regulation PARP4 FAS 21379337 3051301 Positive_regulation PARP4 FAS 23577779 1480353 Positive_regulation PARP4 FAS 23577779 1480354 Positive_regulation PARP4 FAS 23577779 1480572 Positive_regulation PARP4 FOLR1 20069122 1671687 Positive_regulation PARP4 IFI27 21424700 1148146 Positive_regulation PARP4 MIP 21347304 2503588 Positive_regulation PARP4 MMP28 19907806 512451 Positive_regulation PARP4 MMP7 19907806 512466 Positive_regulation PARP4 TNF 15642133 102120 Positive_regulation PARP4 TNF 20109177 118178 Positive_regulation PARP4 TNF 23202463 3221525 Positive_regulation PARP4 TNF 23593410 2781193 Positive_regulation PARP4 TNF 23603982 17472 Positive_regulation PARP4 TNFSF10 20113484 1853249 Positive_regulation PARP4 TNFSF10 20661477 2456818 Positive_regulation PARP4 TNFSF10 20661477 2456869 Positive_regulation PARP4 TNFSF10 23517112 268078 Positive_regulation PARP4 TNFSF10 24204567 2873043 Positive_regulation PARP4 TNFSF10 24566141 1124119 Positive_regulation PARP4 TNFSF10 25191654 861462 Positive_regulation PARP4 TNFSF10 9105050 1459786 Positive_regulation PARP6 CCND1 20531415 434970 Positive_regulation PARP6 FAS 15188008 424545 Positive_regulation PARP6 FAS 21379337 3051299 Positive_regulation PARP6 FAS 23577779 1480349 Positive_regulation PARP6 FAS 23577779 1480350 Positive_regulation PARP6 FAS 23577779 1480544 Positive_regulation PARP6 FOLR1 20069122 1671677 Positive_regulation PARP6 IFI27 21424700 1148140 Positive_regulation PARP6 MIP 21347304 2503586 Positive_regulation PARP6 MMP28 19907806 512407 Positive_regulation PARP6 MMP7 19907806 512422 Positive_regulation PARP6 TNF 15642133 102116 Positive_regulation PARP6 TNF 20109177 118172 Positive_regulation PARP6 TNF 23202463 3221523 Positive_regulation PARP6 TNF 23593410 2781191 Positive_regulation PARP6 TNF 23603982 17470 Positive_regulation PARP6 TNFSF10 20113484 1853247 Positive_regulation PARP6 TNFSF10 20661477 2456816 Positive_regulation PARP6 TNFSF10 20661477 2456867 Positive_regulation PARP6 TNFSF10 23517112 268076 Positive_regulation PARP6 TNFSF10 24204567 2873041 Positive_regulation PARP6 TNFSF10 24566141 1124117 Positive_regulation PARP6 TNFSF10 25191654 861460 Positive_regulation PARP6 TNFSF10 9105050 1459784 Positive_regulation PARP8 CCND1 20531415 434966 Positive_regulation PARP8 FAS 15188008 424543 Positive_regulation PARP8 FAS 21379337 3051297 Positive_regulation PARP8 FAS 23577779 1480345 Positive_regulation PARP8 FAS 23577779 1480346 Positive_regulation PARP8 FAS 23577779 1480516 Positive_regulation PARP8 FOLR1 20069122 1671667 Positive_regulation PARP8 IFI27 21424700 1148134 Positive_regulation PARP8 MIP 21347304 2503584 Positive_regulation PARP8 MMP28 19907806 512363 Positive_regulation PARP8 MMP7 19907806 512378 Positive_regulation PARP8 TNF 15642133 102112 Positive_regulation PARP8 TNF 20109177 118166 Positive_regulation PARP8 TNF 23202463 3221521 Positive_regulation PARP8 TNF 23593410 2781189 Positive_regulation PARP8 TNF 23603982 17468 Positive_regulation PARP8 TNFSF10 20113484 1853245 Positive_regulation PARP8 TNFSF10 20661477 2456814 Positive_regulation PARP8 TNFSF10 20661477 2456865 Positive_regulation PARP8 TNFSF10 23517112 268074 Positive_regulation PARP8 TNFSF10 24204567 2873039 Positive_regulation PARP8 TNFSF10 24566141 1124115 Positive_regulation PARP8 TNFSF10 25191654 861458 Positive_regulation PARP8 TNFSF10 9105050 1459782 Positive_regulation PARP9 CCND1 20531415 434947 Positive_regulation PARP9 FAS 15188008 424540 Positive_regulation PARP9 FAS 21379337 3051294 Positive_regulation PARP9 FAS 23577779 1480339 Positive_regulation PARP9 FAS 23577779 1480340 Positive_regulation PARP9 FAS 23577779 1480474 Positive_regulation PARP9 FOLR1 20069122 1671652 Positive_regulation PARP9 IFI27 21424700 1148125 Positive_regulation PARP9 MIP 21347304 2503581 Positive_regulation PARP9 MMP28 19907806 512297 Positive_regulation PARP9 MMP7 19907806 512312 Positive_regulation PARP9 TNF 15642133 102106 Positive_regulation PARP9 TNF 20109177 118157 Positive_regulation PARP9 TNF 23202463 3221518 Positive_regulation PARP9 TNF 23593410 2781186 Positive_regulation PARP9 TNF 23603982 17465 Positive_regulation PARP9 TNFSF10 20113484 1853242 Positive_regulation PARP9 TNFSF10 20661477 2456811 Positive_regulation PARP9 TNFSF10 20661477 2456862 Positive_regulation PARP9 TNFSF10 23517112 268071 Positive_regulation PARP9 TNFSF10 24204567 2873036 Positive_regulation PARP9 TNFSF10 24566141 1124112 Positive_regulation PARP9 TNFSF10 25191654 861455 Positive_regulation PARP9 TNFSF10 9105050 1459779 Positive_regulation PARVA EPHB2 15353548 1311972 Positive_regulation PARVA EPHB2 15353548 1311977 Positive_regulation PARVA EPHB2 15353548 1311980 Positive_regulation PAWR TNFSF10 22461781 924821 Positive_regulation PAX2 OSR1 23560233 85992 Positive_regulation PAX3 CCND1 23469153 2762488 Positive_regulation PAX3 FOXO1 22533991 264555 Positive_regulation PAX3 FOXO1 23206814 3161254 Positive_regulation PAX3 FOXO1 23799156 2807582 Positive_regulation PAX6 EPHB2 17277739 1906413 Positive_regulation PAX7 ANGPT1 25364710 861543 Positive_regulation PAX7 TNF 20814569 2473460 Positive_regulation PAX7 TNF 24971321 193314 Positive_regulation PCBD1 ARSA 22165954 2254467 Positive_regulation PCBD1 FAS 10330437 1511765 Positive_regulation PCBD1 FAS 10579724 1253141 Positive_regulation PCBD1 FAS 10579724 1253158 Positive_regulation PCBD1 FAS 10579724 1253162 Positive_regulation PCBD1 FAS 10579724 1253164 Positive_regulation PCBD1 FAS 10579724 1253166 Positive_regulation PCBD1 FAS 11980919 1282355 Positive_regulation PCBD1 FAS 21364663 550081 Positive_regulation PCBD1 FAS 23202447 3221340 Positive_regulation PCBD1 FAS 8655577 1451824 Positive_regulation PCBD1 FAS 8920897 1599542 Positive_regulation PCBD1 TNF 19060883 1983091 Positive_regulation PCBD1 TNF 19060883 1983092 Positive_regulation PCBD1 TNF 19060883 1983093 Positive_regulation PCBD1 TNF 19060883 1983097 Positive_regulation PCBD1 TNF 19060883 1983098 Positive_regulation PCBD1 TNF 19060883 1983102 Positive_regulation PCBD1 TNF 21364663 550080 Positive_regulation PCBD1 TNF 8655577 1451807 Positive_regulation PCBD1 TNFSF10 21364663 550082 Positive_regulation PCDH19 CDH2 22184198 1394560 Positive_regulation PCDH19 CDH2 22184198 1394564 Positive_regulation PCDH19 CISH 21115806 1383063 Positive_regulation PCDH19 CTCF 22210889 2071200 Positive_regulation PCDH19 CTCF 22988450 882902 Positive_regulation PCDH19 REST 20385576 2052940 Positive_regulation PCDH19 SMCHD1 24818964 2968661 Positive_regulation PCDH8 CTCF 22210889 2071205 Positive_regulation PCDH8 CTCF 22988450 882907 Positive_regulation PCDH8 REST 20385576 2052945 Positive_regulation PCDH8 SMCHD1 24818964 2968666 Positive_regulation PCK1 FOXO1 21804540 1961596 Positive_regulation PCK1 FOXO1 23066095 2081381 Positive_regulation PCK2 FOXO1 21804540 1961597 Positive_regulation PCM1 NES 15251038 277809 Positive_regulation PCMT1 EPHB2 21841813 13270 Positive_regulation PCMT1 EPHB2 24358311 2899457 Positive_regulation PCMT1 EPHB2 24358311 2899496 Positive_regulation PCMT1 EPHB2 24358311 2899527 Positive_regulation PCNA CAPN8 22432027 2611656 Positive_regulation PCNA CCND1 16942622 279255 Positive_regulation PCNA CCND1 23462806 440312 Positive_regulation PCNA CCND1 24212955 499349 Positive_regulation PCNA CCND1 24662164 2118597 Positive_regulation PCNA CCND1 24775809 1874053 Positive_regulation PCNA CCND1 9026502 1459217 Positive_regulation PCNA CCND1 PMC3300864 477142 Positive_regulation PCNA EPHB2 18404517 3089664 Positive_regulation PCNA EPHB2 21283538 2495595 Positive_regulation PCNA EPHB2 22028449 788581 Positive_regulation PCNA EPHB2 22310282 2146191 Positive_regulation PCNA FOXO1 11277966 993993 Positive_regulation PCNA IFI27 15606917 1734121 Positive_regulation PCNA IFI27 19457236 463983 Positive_regulation PCNA IFI27 21892199 13276 Positive_regulation PCNA IFI27 23511556 440328 Positive_regulation PCNA IFI27 24023847 2843809 Positive_regulation PCNA MAP2K6 11238451 1267712 Positive_regulation PCNA MAP2K6 18404517 3089677 Positive_regulation PCNA TNF 16987412 384041 Positive_regulation PCNA TNF 21880146 1863098 Positive_regulation PCNA TNF 21880146 1863099 Positive_regulation PCNA TNF 22096364 1628323 Positive_regulation PCNT NES 15251038 277765 Positive_regulation PCSK9 ANXA2 22848640 2669930 Positive_regulation PCSK9 ANXA2 22848640 2669934 Positive_regulation PCSK9 APLP2 23430252 1206609 Positive_regulation PCSK9 APLP2 23430252 1206617 Positive_regulation PCSK9 APOB 19196236 146451 Positive_regulation PCSK9 APOB 23544125 2773539 Positive_regulation PCSK9 CHRD 23430252 1206567 Positive_regulation PCSK9 CHRD 23430252 1206568 Positive_regulation PCSK9 ECD 23400816 1206486 Positive_regulation PCSK9 EEF1A2 19687008 1166620 Positive_regulation PCSK9 EEF1A2 21352602 1723457 Positive_regulation PCSK9 EEF1A2 21352602 1723458 Positive_regulation PCSK9 EEF1A2 21352602 1723463 Positive_regulation PCSK9 EEF1A2 22355267 1059723 Positive_regulation PCSK9 EEF1A2 22355267 1059733 Positive_regulation PCSK9 EEF1A2 25349780 854161 Positive_regulation PCSK9 EEF1A2 25349780 854163 Positive_regulation PCSK9 EEF1A2 25426564 658123 Positive_regulation PCSK9 EEF1A2 25426564 658125 Positive_regulation PCSK9 HNF1A 19687008 1166606 Positive_regulation PCSK9 HNF1A 19687008 1166617 Positive_regulation PCSK9 HNF1A 19687008 1166623 Positive_regulation PCSK9 HNF1A 19687008 1166625 Positive_regulation PCSK9 HNF1A 22992388 1724960 Positive_regulation PCSK9 HNF1A 22998978 1724991 Positive_regulation PCSK9 HNF1A 24115837 742819 Positive_regulation PCSK9 HNF1A 24755036 1701684 Positive_regulation PCSK9 HNF1A 25110901 691668 Positive_regulation PCSK9 HNF1A 25110901 691681 Positive_regulation PCSK9 INS 19687008 1166613 Positive_regulation PCSK9 INS 21352602 1723459 Positive_regulation PCSK9 INS 25042549 19287 Positive_regulation PCSK9 LDLR 22848640 2669927 Positive_regulation PCSK9 LDLR 23400816 1206487 Positive_regulation PCSK9 LDLR 23400816 1206493 Positive_regulation PCSK9 LDLR 23430252 1206569 Positive_regulation PCSK9 LDLR 23430252 1206589 Positive_regulation PCSK9 LDLR 23430252 1206590 Positive_regulation PCSK9 LDLR 24115837 742804 Positive_regulation PCSK9 LDLR 24296664 1637905 Positive_regulation PCSK9 LDLR 24755036 1701692 Positive_regulation PCSK9 LRP1 23675525 2793529 Positive_regulation PCSK9 RETN 25600226 143166 Positive_regulation PCSK9 SEC24A 23580231 748953 Positive_regulation PCSK9 SEC24A 23580231 748954 Positive_regulation PCSK9 SIM2 24755036 1701680 Positive_regulation PCSK9 SREBF1 18547436 1722727 Positive_regulation PCSK9 SREBF1 23298392 2113729 Positive_regulation PCSK9 SREBF1 24755036 1701685 Positive_regulation PCSK9 SREBF2 18547436 1722728 Positive_regulation PCSK9 SREBF2 19687008 1166605 Positive_regulation PCSK9 SREBF2 19687008 1166619 Positive_regulation PCSK9 SREBF2 21352602 1723465 Positive_regulation PCSK9 SREBF2 22355267 1059728 Positive_regulation PCSK9 SREBF2 22992388 1724957 Positive_regulation PCSK9 SREBF2 23130136 1157031 Positive_regulation PCSK9 SREBF2 23130136 1157032 Positive_regulation PCSK9 SREBF2 23400816 1206458 Positive_regulation PCSK9 SREBF2 24755036 1701686 Positive_regulation PCSK9 SREBF2 24755036 1701687 Positive_regulation PCSK9 SREBF2 24755036 1701689 Positive_regulation PCSK9 STS 22998978 1724986 Positive_regulation PCSK9 STS 22998978 1724990 Positive_regulation PDB1 TNF 2677211 1577814 Positive_regulation PDCD1 AXIN2 11739413 1277209 Positive_regulation PDCD1 CAPN8 24009739 2841490 Positive_regulation PDCD1 DAPK1 22160140 2170547 Positive_regulation PDCD1 FAS 10684855 1514399 Positive_regulation PDCD1 FAS 14737201 2255406 Positive_regulation PDCD1 FAS 19527527 1675606 Positive_regulation PDCD1 FAS 19527527 1675620 Positive_regulation PDCD1 FAS 22006249 616699 Positive_regulation PDCD1 FAS 23247502 3221984 Positive_regulation PDCD1 FAS 23247502 3221985 Positive_regulation PDCD1 FAS 24523856 2921715 Positive_regulation PDCD1 FAS 25133196 1623039 Positive_regulation PDCD1 FAS 25177675 1051050 Positive_regulation PDCD1 FAS 7504062 1588763 Positive_regulation PDCD1 FAS 7595225 1590955 Positive_regulation PDCD1 FAS 7595231 1591007 Positive_regulation PDCD1 FAS 7759991 1592095 Positive_regulation PDCD1 FAS 8642249 1596374 Positive_regulation PDCD1 FAS 8642317 1596877 Positive_regulation PDCD1 FAS 8666935 1597291 Positive_regulation PDCD1 FAS 8666944 1597622 Positive_regulation PDCD1 FAS 8676065 1597743 Positive_regulation PDCD1 FAS 8676075 1597860 Positive_regulation PDCD1 FAS 8760796 1598734 Positive_regulation PDCD1 FAS 8760802 1598803 Positive_regulation PDCD1 FAS 8879222 1599226 Positive_regulation PDCD1 FAS 9126933 1601107 Positive_regulation PDCD1 MMP28 11250717 456647 Positive_regulation PDCD1 MMP7 11250717 456662 Positive_regulation PDCD1 TGM2 23554628 1225786 Positive_regulation PDCD1 TNF 10684855 1514398 Positive_regulation PDCD1 TNF 11686888 3103504 Positive_regulation PDCD1 TNF 12816542 3095031 Positive_regulation PDCD1 TNF 12932288 99910 Positive_regulation PDCD1 TNF 16191192 318551 Positive_regulation PDCD1 TNF 16584110 630388 Positive_regulation PDCD1 TNF 17341304 108141 Positive_regulation PDCD1 TNF 18822184 3212657 Positive_regulation PDCD1 TNF 19527527 1675619 Positive_regulation PDCD1 TNF 20849588 120099 Positive_regulation PDCD1 TNF 22292020 2591885 Positive_regulation PDCD1 TNF 23006927 366910 Positive_regulation PDCD1 TNF 24979756 2985708 Positive_regulation PDCD1 TNF 8046331 1593797 Positive_regulation PDCD1 TNF 8046331 1593805 Positive_regulation PDCD1 TNF 9653098 1603156 Positive_regulation PDCD1 TNFSF10 15833141 3104992 Positive_regulation PDCD1 TNFSF10 18662397 1242902 Positive_regulation PDCD1 TNFSF10 19196465 112749 Positive_regulation PDCD1 TNFSF10 19196465 112762 Positive_regulation PDCD1 TNFSF10 19196465 112772 Positive_regulation PDCD1 TNFSF10 22654557 678413 Positive_regulation PDCD1 TNFSF10 23580227 1636127 Positive_regulation PDCD1 TNFSF10 24402744 492181 Positive_regulation PDCD1 TNFSF10 24402744 492198 Positive_regulation PDCD1 WIF1 24632949 548664 Positive_regulation PDCD10 AXIN2 11739413 1277211 Positive_regulation PDCD10 CAPN8 24009739 2841504 Positive_regulation PDCD10 DAPK1 22160140 2170550 Positive_regulation PDCD10 FAS 10684855 1514401 Positive_regulation PDCD10 FAS 14737201 2255407 Positive_regulation PDCD10 FAS 19527527 1675607 Positive_regulation PDCD10 FAS 19527527 1675622 Positive_regulation PDCD10 FAS 22006249 616700 Positive_regulation PDCD10 FAS 23247502 3221986 Positive_regulation PDCD10 FAS 23247502 3221987 Positive_regulation PDCD10 FAS 24523856 2921716 Positive_regulation PDCD10 FAS 25133196 1623041 Positive_regulation PDCD10 FAS 25177675 1051052 Positive_regulation PDCD10 FAS 7504062 1588764 Positive_regulation PDCD10 FAS 7595225 1590957 Positive_regulation PDCD10 FAS 7595231 1591009 Positive_regulation PDCD10 FAS 7759991 1592096 Positive_regulation PDCD10 FAS 8642249 1596376 Positive_regulation PDCD10 FAS 8642317 1596879 Positive_regulation PDCD10 FAS 8666935 1597293 Positive_regulation PDCD10 FAS 8666944 1597624 Positive_regulation PDCD10 FAS 8676065 1597745 Positive_regulation PDCD10 FAS 8676075 1597861 Positive_regulation PDCD10 FAS 8760796 1598736 Positive_regulation PDCD10 FAS 8760802 1598805 Positive_regulation PDCD10 FAS 8879222 1599228 Positive_regulation PDCD10 FAS 9126933 1601109 Positive_regulation PDCD10 MMP28 11250717 456669 Positive_regulation PDCD10 MMP7 11250717 456684 Positive_regulation PDCD10 TGM2 23554628 1225787 Positive_regulation PDCD10 TNF 10684855 1514400 Positive_regulation PDCD10 TNF 11686888 3103505 Positive_regulation PDCD10 TNF 12816542 3095032 Positive_regulation PDCD10 TNF 12932288 99912 Positive_regulation PDCD10 TNF 16191192 318552 Positive_regulation PDCD10 TNF 16584110 630389 Positive_regulation PDCD10 TNF 17341304 108142 Positive_regulation PDCD10 TNF 18822184 3212658 Positive_regulation PDCD10 TNF 19527527 1675621 Positive_regulation PDCD10 TNF 20849588 120100 Positive_regulation PDCD10 TNF 22292020 2591886 Positive_regulation PDCD10 TNF 23006927 366911 Positive_regulation PDCD10 TNF 24979756 2985709 Positive_regulation PDCD10 TNF 8046331 1593798 Positive_regulation PDCD10 TNF 8046331 1593806 Positive_regulation PDCD10 TNF 9653098 1603157 Positive_regulation PDCD10 TNFSF10 15833141 3104993 Positive_regulation PDCD10 TNFSF10 18662397 1242904 Positive_regulation PDCD10 TNFSF10 19196465 112750 Positive_regulation PDCD10 TNFSF10 19196465 112763 Positive_regulation PDCD10 TNFSF10 19196465 112773 Positive_regulation PDCD10 TNFSF10 22654557 678414 Positive_regulation PDCD10 TNFSF10 23580227 1636128 Positive_regulation PDCD10 TNFSF10 24402744 492182 Positive_regulation PDCD10 TNFSF10 24402744 492199 Positive_regulation PDCD10 WIF1 24632949 548665 Positive_regulation PDCD11 AXIN2 11739413 1277207 Positive_regulation PDCD11 CAPN8 24009739 2841476 Positive_regulation PDCD11 DAPK1 22160140 2170520 Positive_regulation PDCD11 FAS 10684855 1514397 Positive_regulation PDCD11 FAS 14737201 2255405 Positive_regulation PDCD11 FAS 19527527 1675605 Positive_regulation PDCD11 FAS 19527527 1675618 Positive_regulation PDCD11 FAS 22006249 616698 Positive_regulation PDCD11 FAS 23247502 3221981 Positive_regulation PDCD11 FAS 23247502 3221982 Positive_regulation PDCD11 FAS 24523856 2921714 Positive_regulation PDCD11 FAS 25133196 1623037 Positive_regulation PDCD11 FAS 25177675 1051048 Positive_regulation PDCD11 FAS 7504062 1588762 Positive_regulation PDCD11 FAS 7595225 1590952 Positive_regulation PDCD11 FAS 7595231 1591005 Positive_regulation PDCD11 FAS 7759991 1592094 Positive_regulation PDCD11 FAS 8642249 1596372 Positive_regulation PDCD11 FAS 8642317 1596875 Positive_regulation PDCD11 FAS 8666935 1597289 Positive_regulation PDCD11 FAS 8666944 1597620 Positive_regulation PDCD11 FAS 8676065 1597741 Positive_regulation PDCD11 FAS 8676075 1597857 Positive_regulation PDCD11 FAS 8760796 1598732 Positive_regulation PDCD11 FAS 8760802 1598800 Positive_regulation PDCD11 FAS 8879222 1599224 Positive_regulation PDCD11 FAS 9126933 1601105 Positive_regulation PDCD11 MMP28 11250717 456625 Positive_regulation PDCD11 MMP7 11250717 456640 Positive_regulation PDCD11 TGM2 23554628 1225785 Positive_regulation PDCD11 TNF 10684855 1514396 Positive_regulation PDCD11 TNF 11686888 3103503 Positive_regulation PDCD11 TNF 12816542 3095030 Positive_regulation PDCD11 TNF 12932288 99908 Positive_regulation PDCD11 TNF 16191192 318550 Positive_regulation PDCD11 TNF 16584110 630387 Positive_regulation PDCD11 TNF 17341304 108140 Positive_regulation PDCD11 TNF 18822184 3212656 Positive_regulation PDCD11 TNF 19527527 1675617 Positive_regulation PDCD11 TNF 20849588 120096 Positive_regulation PDCD11 TNF 22292020 2591884 Positive_regulation PDCD11 TNF 23006927 366909 Positive_regulation PDCD11 TNF 24979756 2985707 Positive_regulation PDCD11 TNF 8046331 1593796 Positive_regulation PDCD11 TNF 8046331 1593804 Positive_regulation PDCD11 TNF 9653098 1603155 Positive_regulation PDCD11 TNFSF10 15833141 3104991 Positive_regulation PDCD11 TNFSF10 18662397 1242900 Positive_regulation PDCD11 TNFSF10 19196465 112748 Positive_regulation PDCD11 TNFSF10 19196465 112761 Positive_regulation PDCD11 TNFSF10 19196465 112769 Positive_regulation PDCD11 TNFSF10 22654557 678412 Positive_regulation PDCD11 TNFSF10 23580227 1636126 Positive_regulation PDCD11 TNFSF10 24402744 492180 Positive_regulation PDCD11 TNFSF10 24402744 492197 Positive_regulation PDCD11 WIF1 24632949 548655 Positive_regulation PDCD1LG2 TLR7 19294011 2214889 Positive_regulation PDCD2 AXIN2 11739413 1277213 Positive_regulation PDCD2 CAPN8 24009739 2841518 Positive_regulation PDCD2 DAPK1 22160140 2170553 Positive_regulation PDCD2 FAS 10684855 1514403 Positive_regulation PDCD2 FAS 14737201 2255408 Positive_regulation PDCD2 FAS 19527527 1675608 Positive_regulation PDCD2 FAS 19527527 1675624 Positive_regulation PDCD2 FAS 22006249 616701 Positive_regulation PDCD2 FAS 23247502 3221988 Positive_regulation PDCD2 FAS 23247502 3221989 Positive_regulation PDCD2 FAS 24523856 2921717 Positive_regulation PDCD2 FAS 25133196 1623043 Positive_regulation PDCD2 FAS 25177675 1051054 Positive_regulation PDCD2 FAS 7504062 1588765 Positive_regulation PDCD2 FAS 7595225 1590959 Positive_regulation PDCD2 FAS 7595231 1591011 Positive_regulation PDCD2 FAS 7759991 1592097 Positive_regulation PDCD2 FAS 8642249 1596378 Positive_regulation PDCD2 FAS 8642317 1596881 Positive_regulation PDCD2 FAS 8666935 1597295 Positive_regulation PDCD2 FAS 8666944 1597626 Positive_regulation PDCD2 FAS 8676065 1597747 Positive_regulation PDCD2 FAS 8676075 1597862 Positive_regulation PDCD2 FAS 8760796 1598738 Positive_regulation PDCD2 FAS 8760802 1598807 Positive_regulation PDCD2 FAS 8879222 1599230 Positive_regulation PDCD2 FAS 9126933 1601111 Positive_regulation PDCD2 MMP28 11250717 456691 Positive_regulation PDCD2 MMP7 11250717 456706 Positive_regulation PDCD2 TGM2 23554628 1225788 Positive_regulation PDCD2 TNF 10684855 1514402 Positive_regulation PDCD2 TNF 11686888 3103506 Positive_regulation PDCD2 TNF 12816542 3095033 Positive_regulation PDCD2 TNF 12932288 99914 Positive_regulation PDCD2 TNF 16191192 318553 Positive_regulation PDCD2 TNF 16584110 630390 Positive_regulation PDCD2 TNF 17341304 108143 Positive_regulation PDCD2 TNF 18822184 3212659 Positive_regulation PDCD2 TNF 19527527 1675623 Positive_regulation PDCD2 TNF 20849588 120101 Positive_regulation PDCD2 TNF 22292020 2591887 Positive_regulation PDCD2 TNF 23006927 366912 Positive_regulation PDCD2 TNF 24979756 2985710 Positive_regulation PDCD2 TNF 8046331 1593799 Positive_regulation PDCD2 TNF 8046331 1593807 Positive_regulation PDCD2 TNF 9653098 1603158 Positive_regulation PDCD2 TNFSF10 15833141 3104994 Positive_regulation PDCD2 TNFSF10 18662397 1242906 Positive_regulation PDCD2 TNFSF10 19196465 112751 Positive_regulation PDCD2 TNFSF10 19196465 112764 Positive_regulation PDCD2 TNFSF10 19196465 112774 Positive_regulation PDCD2 TNFSF10 22654557 678415 Positive_regulation PDCD2 TNFSF10 23580227 1636129 Positive_regulation PDCD2 TNFSF10 24402744 492183 Positive_regulation PDCD2 TNFSF10 24402744 492200 Positive_regulation PDCD2 WIF1 24632949 548666 Positive_regulation PDCD4 AXIN2 11739413 1277215 Positive_regulation PDCD4 CAPN8 24009739 2841532 Positive_regulation PDCD4 DAPK1 22160140 2170556 Positive_regulation PDCD4 FAS 10684855 1514405 Positive_regulation PDCD4 FAS 14737201 2255409 Positive_regulation PDCD4 FAS 19527527 1675609 Positive_regulation PDCD4 FAS 19527527 1675626 Positive_regulation PDCD4 FAS 22006249 616702 Positive_regulation PDCD4 FAS 23247502 3221990 Positive_regulation PDCD4 FAS 23247502 3221991 Positive_regulation PDCD4 FAS 24523856 2921718 Positive_regulation PDCD4 FAS 25133196 1623045 Positive_regulation PDCD4 FAS 25177675 1051056 Positive_regulation PDCD4 FAS 7504062 1588766 Positive_regulation PDCD4 FAS 7595225 1590961 Positive_regulation PDCD4 FAS 7595231 1591013 Positive_regulation PDCD4 FAS 7759991 1592098 Positive_regulation PDCD4 FAS 8642249 1596380 Positive_regulation PDCD4 FAS 8642317 1596883 Positive_regulation PDCD4 FAS 8666935 1597297 Positive_regulation PDCD4 FAS 8666944 1597628 Positive_regulation PDCD4 FAS 8676065 1597749 Positive_regulation PDCD4 FAS 8676075 1597863 Positive_regulation PDCD4 FAS 8760796 1598740 Positive_regulation PDCD4 FAS 8760802 1598809 Positive_regulation PDCD4 FAS 8879222 1599232 Positive_regulation PDCD4 FAS 9126933 1601113 Positive_regulation PDCD4 FOXO1 23878722 749586 Positive_regulation PDCD4 IFI27 22272332 2589642 Positive_regulation PDCD4 MMP28 11250717 456713 Positive_regulation PDCD4 MMP7 11250717 456728 Positive_regulation PDCD4 TGM2 23554628 1225789 Positive_regulation PDCD4 TNF 10684855 1514404 Positive_regulation PDCD4 TNF 11686888 3103507 Positive_regulation PDCD4 TNF 12816542 3095034 Positive_regulation PDCD4 TNF 12932288 99916 Positive_regulation PDCD4 TNF 16191192 318554 Positive_regulation PDCD4 TNF 16584110 630391 Positive_regulation PDCD4 TNF 17341304 108144 Positive_regulation PDCD4 TNF 18822184 3212660 Positive_regulation PDCD4 TNF 19527527 1675625 Positive_regulation PDCD4 TNF 20849588 120102 Positive_regulation PDCD4 TNF 22292020 2591888 Positive_regulation PDCD4 TNF 23006927 366913 Positive_regulation PDCD4 TNF 24979756 2985711 Positive_regulation PDCD4 TNF 8046331 1593800 Positive_regulation PDCD4 TNF 8046331 1593808 Positive_regulation PDCD4 TNF 9653098 1603159 Positive_regulation PDCD4 TNFSF10 15833141 3104995 Positive_regulation PDCD4 TNFSF10 18662397 1242908 Positive_regulation PDCD4 TNFSF10 19196465 112752 Positive_regulation PDCD4 TNFSF10 19196465 112765 Positive_regulation PDCD4 TNFSF10 19196465 112775 Positive_regulation PDCD4 TNFSF10 22654557 678416 Positive_regulation PDCD4 TNFSF10 23580227 1636130 Positive_regulation PDCD4 TNFSF10 24402744 492184 Positive_regulation PDCD4 TNFSF10 24402744 492201 Positive_regulation PDCD4 WIF1 24632949 548667 Positive_regulation PDCD5 AXIN2 11739413 1277217 Positive_regulation PDCD5 CAPN8 24009739 2841546 Positive_regulation PDCD5 DAPK1 22160140 2170559 Positive_regulation PDCD5 FAS 10684855 1514407 Positive_regulation PDCD5 FAS 14737201 2255410 Positive_regulation PDCD5 FAS 19527527 1675610 Positive_regulation PDCD5 FAS 19527527 1675628 Positive_regulation PDCD5 FAS 22006249 616703 Positive_regulation PDCD5 FAS 23247502 3221992 Positive_regulation PDCD5 FAS 23247502 3221993 Positive_regulation PDCD5 FAS 24523856 2921719 Positive_regulation PDCD5 FAS 25133196 1623047 Positive_regulation PDCD5 FAS 25177675 1051058 Positive_regulation PDCD5 FAS 7504062 1588767 Positive_regulation PDCD5 FAS 7595225 1590963 Positive_regulation PDCD5 FAS 7595231 1591015 Positive_regulation PDCD5 FAS 7759991 1592099 Positive_regulation PDCD5 FAS 8642249 1596382 Positive_regulation PDCD5 FAS 8642317 1596885 Positive_regulation PDCD5 FAS 8666935 1597299 Positive_regulation PDCD5 FAS 8666944 1597630 Positive_regulation PDCD5 FAS 8676065 1597751 Positive_regulation PDCD5 FAS 8676075 1597864 Positive_regulation PDCD5 FAS 8760796 1598742 Positive_regulation PDCD5 FAS 8760802 1598811 Positive_regulation PDCD5 FAS 8879222 1599234 Positive_regulation PDCD5 FAS 9126933 1601115 Positive_regulation PDCD5 MMP28 11250717 456735 Positive_regulation PDCD5 MMP7 11250717 456750 Positive_regulation PDCD5 TGM2 23554628 1225790 Positive_regulation PDCD5 TNF 10684855 1514406 Positive_regulation PDCD5 TNF 11686888 3103508 Positive_regulation PDCD5 TNF 12816542 3095035 Positive_regulation PDCD5 TNF 12932288 99918 Positive_regulation PDCD5 TNF 16191192 318555 Positive_regulation PDCD5 TNF 16584110 630392 Positive_regulation PDCD5 TNF 17341304 108145 Positive_regulation PDCD5 TNF 18822184 3212661 Positive_regulation PDCD5 TNF 19527527 1675627 Positive_regulation PDCD5 TNF 20849588 120103 Positive_regulation PDCD5 TNF 22292020 2591889 Positive_regulation PDCD5 TNF 23006927 366914 Positive_regulation PDCD5 TNF 24979756 2985712 Positive_regulation PDCD5 TNF 8046331 1593801 Positive_regulation PDCD5 TNF 8046331 1593809 Positive_regulation PDCD5 TNF 9653098 1603160 Positive_regulation PDCD5 TNFSF10 15833141 3104996 Positive_regulation PDCD5 TNFSF10 18662397 1242910 Positive_regulation PDCD5 TNFSF10 19196465 112753 Positive_regulation PDCD5 TNFSF10 19196465 112766 Positive_regulation PDCD5 TNFSF10 19196465 112776 Positive_regulation PDCD5 TNFSF10 22654557 678417 Positive_regulation PDCD5 TNFSF10 23580227 1636131 Positive_regulation PDCD5 TNFSF10 24402744 492185 Positive_regulation PDCD5 TNFSF10 24402744 492202 Positive_regulation PDCD5 WIF1 24632949 548668 Positive_regulation PDCD6 AXIN2 11739413 1277219 Positive_regulation PDCD6 CAPN8 24009739 2841560 Positive_regulation PDCD6 DAPK1 22160140 2170562 Positive_regulation PDCD6 FAS 10684855 1514409 Positive_regulation PDCD6 FAS 14737201 2255411 Positive_regulation PDCD6 FAS 19527527 1675611 Positive_regulation PDCD6 FAS 19527527 1675630 Positive_regulation PDCD6 FAS 22006249 616704 Positive_regulation PDCD6 FAS 23247502 3221994 Positive_regulation PDCD6 FAS 23247502 3221995 Positive_regulation PDCD6 FAS 24523856 2921720 Positive_regulation PDCD6 FAS 25133196 1623049 Positive_regulation PDCD6 FAS 25177675 1051060 Positive_regulation PDCD6 FAS 7504062 1588768 Positive_regulation PDCD6 FAS 7595225 1590965 Positive_regulation PDCD6 FAS 7595231 1591017 Positive_regulation PDCD6 FAS 7759991 1592100 Positive_regulation PDCD6 FAS 8642249 1596384 Positive_regulation PDCD6 FAS 8642317 1596887 Positive_regulation PDCD6 FAS 8666935 1597301 Positive_regulation PDCD6 FAS 8666944 1597632 Positive_regulation PDCD6 FAS 8676065 1597753 Positive_regulation PDCD6 FAS 8676075 1597865 Positive_regulation PDCD6 FAS 8760796 1598744 Positive_regulation PDCD6 FAS 8760802 1598813 Positive_regulation PDCD6 FAS 8879222 1599236 Positive_regulation PDCD6 FAS 9126933 1601117 Positive_regulation PDCD6 MMP28 11250717 456757 Positive_regulation PDCD6 MMP7 11250717 456772 Positive_regulation PDCD6 TGM2 23554628 1225791 Positive_regulation PDCD6 TNF 10684855 1514408 Positive_regulation PDCD6 TNF 11686888 3103509 Positive_regulation PDCD6 TNF 12816542 3095036 Positive_regulation PDCD6 TNF 12932288 99920 Positive_regulation PDCD6 TNF 16191192 318556 Positive_regulation PDCD6 TNF 16584110 630393 Positive_regulation PDCD6 TNF 17341304 108146 Positive_regulation PDCD6 TNF 18822184 3212662 Positive_regulation PDCD6 TNF 19527527 1675629 Positive_regulation PDCD6 TNF 20849588 120104 Positive_regulation PDCD6 TNF 22292020 2591890 Positive_regulation PDCD6 TNF 23006927 366915 Positive_regulation PDCD6 TNF 24979756 2985713 Positive_regulation PDCD6 TNF 8046331 1593802 Positive_regulation PDCD6 TNF 8046331 1593810 Positive_regulation PDCD6 TNF 9653098 1603161 Positive_regulation PDCD6 TNFSF10 15833141 3104997 Positive_regulation PDCD6 TNFSF10 18662397 1242912 Positive_regulation PDCD6 TNFSF10 19196465 112754 Positive_regulation PDCD6 TNFSF10 19196465 112767 Positive_regulation PDCD6 TNFSF10 19196465 112777 Positive_regulation PDCD6 TNFSF10 22654557 678418 Positive_regulation PDCD6 TNFSF10 23580227 1636132 Positive_regulation PDCD6 TNFSF10 24402744 492186 Positive_regulation PDCD6 TNFSF10 24402744 492203 Positive_regulation PDCD6 WIF1 24632949 548669 Positive_regulation PDCD7 AXIN2 11739413 1277221 Positive_regulation PDCD7 CAPN8 24009739 2841574 Positive_regulation PDCD7 DAPK1 22160140 2170565 Positive_regulation PDCD7 FAS 10684855 1514411 Positive_regulation PDCD7 FAS 14737201 2255412 Positive_regulation PDCD7 FAS 19527527 1675612 Positive_regulation PDCD7 FAS 19527527 1675632 Positive_regulation PDCD7 FAS 22006249 616705 Positive_regulation PDCD7 FAS 23247502 3221996 Positive_regulation PDCD7 FAS 23247502 3221997 Positive_regulation PDCD7 FAS 24523856 2921721 Positive_regulation PDCD7 FAS 25133196 1623051 Positive_regulation PDCD7 FAS 25177675 1051062 Positive_regulation PDCD7 FAS 7504062 1588769 Positive_regulation PDCD7 FAS 7595225 1590967 Positive_regulation PDCD7 FAS 7595231 1591019 Positive_regulation PDCD7 FAS 7759991 1592101 Positive_regulation PDCD7 FAS 8642249 1596386 Positive_regulation PDCD7 FAS 8642317 1596889 Positive_regulation PDCD7 FAS 8666935 1597303 Positive_regulation PDCD7 FAS 8666944 1597634 Positive_regulation PDCD7 FAS 8676065 1597755 Positive_regulation PDCD7 FAS 8676075 1597866 Positive_regulation PDCD7 FAS 8760796 1598746 Positive_regulation PDCD7 FAS 8760802 1598815 Positive_regulation PDCD7 FAS 8879222 1599238 Positive_regulation PDCD7 FAS 9126933 1601119 Positive_regulation PDCD7 MMP28 11250717 456779 Positive_regulation PDCD7 MMP7 11250717 456794 Positive_regulation PDCD7 TGM2 23554628 1225792 Positive_regulation PDCD7 TNF 10684855 1514410 Positive_regulation PDCD7 TNF 11686888 3103510 Positive_regulation PDCD7 TNF 12816542 3095037 Positive_regulation PDCD7 TNF 12932288 99922 Positive_regulation PDCD7 TNF 16191192 318557 Positive_regulation PDCD7 TNF 16584110 630394 Positive_regulation PDCD7 TNF 17341304 108147 Positive_regulation PDCD7 TNF 18822184 3212663 Positive_regulation PDCD7 TNF 19527527 1675631 Positive_regulation PDCD7 TNF 20849588 120105 Positive_regulation PDCD7 TNF 22292020 2591891 Positive_regulation PDCD7 TNF 23006927 366916 Positive_regulation PDCD7 TNF 24979756 2985714 Positive_regulation PDCD7 TNF 8046331 1593803 Positive_regulation PDCD7 TNF 8046331 1593811 Positive_regulation PDCD7 TNF 9653098 1603162 Positive_regulation PDCD7 TNFSF10 15833141 3104998 Positive_regulation PDCD7 TNFSF10 18662397 1242914 Positive_regulation PDCD7 TNFSF10 19196465 112755 Positive_regulation PDCD7 TNFSF10 19196465 112768 Positive_regulation PDCD7 TNFSF10 19196465 112778 Positive_regulation PDCD7 TNFSF10 22654557 678419 Positive_regulation PDCD7 TNFSF10 23580227 1636133 Positive_regulation PDCD7 TNFSF10 24402744 492187 Positive_regulation PDCD7 TNFSF10 24402744 492204 Positive_regulation PDCD7 WIF1 24632949 548670 Positive_regulation PDE4B AKT1 24944587 1021495 Positive_regulation PDE4B AKT2 24944587 1021496 Positive_regulation PDE4B AKT3 24944587 1021497 Positive_regulation PDE4B EPHB2 24575381 2163097 Positive_regulation PDE4B HRAS 24944587 1021498 Positive_regulation PDE4B IL2 23451206 2758367 Positive_regulation PDE4B IL2 23451206 2758373 Positive_regulation PDE4B IL2 23451206 2758375 Positive_regulation PDE4B IL2 23451206 2758377 Positive_regulation PDE4B KRAS 22830422 1866212 Positive_regulation PDE4B KRAS 22830422 1866252 Positive_regulation PDE4B KRAS 22830422 1866253 Positive_regulation PDE4B KRAS 22830422 1866257 Positive_regulation PDE4B KRAS 24944587 1021499 Positive_regulation PDE4B NRAS 24944587 1021500 Positive_regulation PDE4B PIK3CA 24944587 1021501 Positive_regulation PDE4B PIK3R1 24944587 1021502 Positive_regulation PDE4B TLR1 23166526 1021741 Positive_regulation PDE4B TLR10 23166526 1021749 Positive_regulation PDE4B TLR2 23166526 1021742 Positive_regulation PDE4B TLR3 23166526 1021743 Positive_regulation PDE4B TLR4 23166526 1021744 Positive_regulation PDE4B TLR5 23166526 1021745 Positive_regulation PDE4B TLR6 23166526 1021750 Positive_regulation PDE4B TLR7 23166526 1021746 Positive_regulation PDE4B TLR8 23166526 1021747 Positive_regulation PDE4B TLR9 23166526 1021748 Positive_regulation PDE4D EPHB2 20819076 148119 Positive_regulation PDE4D EPHB2 24575381 2163098 Positive_regulation PDE4D GPR115 23587879 1901180 Positive_regulation PDE4D GPR132 23587879 1901169 Positive_regulation PDE4D GPR87 23587879 1901250 Positive_regulation PDE6D EPHB2 20979602 3111543 Positive_regulation PDGFA EPHB2 24403605 1820413 Positive_regulation PDGFB CTGF 18923419 763879 Positive_regulation PDGFB EPHB2 10330402 1246085 Positive_regulation PDGFB EPHB2 10330402 1246130 Positive_regulation PDGFB EPHB2 17591920 1341670 Positive_regulation PDGFB EPHB2 21738771 2533809 Positive_regulation PDGFB EPHB2 22315595 1673251 Positive_regulation PDGFB EPHB2 22860018 2671038 Positive_regulation PDGFC FOXO1 21143873 331761 Positive_regulation PDGFC PLAU 23905544 473633 Positive_regulation PDGFRA MAP2K6 24489888 2916668 Positive_regulation PDGFRB ANGPT1 22087289 2571291 Positive_regulation PDGFRB F2R 24215724 538224 Positive_regulation PDHA1 PGC 25610371 872923 Positive_regulation PDHX FOXO1 23555761 2775263 Positive_regulation PDIA3 IFI27 23843843 1238248 Positive_regulation PDIA3 TNF 7519620 1436173 Positive_regulation PDK1 EPHB2 23345981 3177041 Positive_regulation PDK1 FOXO1 23130316 730476 Positive_regulation PDK1 FOXO1 23130316 730609 Positive_regulation PDK2 FOXO1 23130316 730481 Positive_regulation PDK2 FOXO1 23130316 730613 Positive_regulation PDK3 FOXO1 23130316 730486 Positive_regulation PDK3 FOXO1 23130316 730617 Positive_regulation PDK4 FOXO1 22489168 1095512 Positive_regulation PDK4 FOXO1 22911820 2676932 Positive_regulation PDK4 FOXO1 22911820 2676934 Positive_regulation PDK4 FOXO1 23066095 2081382 Positive_regulation PDK4 FOXO1 23130316 730491 Positive_regulation PDK4 FOXO1 23130316 730565 Positive_regulation PDK4 FOXO1 23130316 730622 Positive_regulation PDK4 FOXO1 23443131 1102640 Positive_regulation PDK4 FOXO1 23443131 1102665 Positive_regulation PDK4 PGC 19435887 1165949 Positive_regulation PDK4 PGC 19435887 1165964 Positive_regulation PDK4 PGC 19435887 1165965 Positive_regulation PDK4 PGC 19435887 1165969 Positive_regulation PDK4 PGC 19435887 1165973 Positive_regulation PDK4 PGC 22682013 2113232 Positive_regulation PDK4 PGC 22682013 2113234 Positive_regulation PDK4 PGC 24520982 2113980 Positive_regulation PDK4 PGC 24520982 2113982 Positive_regulation PDLIM7 EPHB2 14981114 1531606 Positive_regulation PDLIM7 EPHB2 22880054 2673930 Positive_regulation PDLIM7 ID1 21701587 2531202 Positive_regulation PDLIM7 ID1 21701587 2531203 Positive_regulation PDLIM7 ID1 21701587 2531205 Positive_regulation PDLIM7 ID1 21701587 2531208 Positive_regulation PDLIM7 ID1 21701587 2531209 Positive_regulation PDLIM7 ID1 21701587 2531212 Positive_regulation PDLIM7 ID1 21701587 2531213 Positive_regulation PDLIM7 ID1 21701587 2531216 Positive_regulation PDLIM7 ID1 25010525 3068573 Positive_regulation PDLIM7 MMP28 24885469 273279 Positive_regulation PDLIM7 MMP7 24885469 273294 Positive_regulation PDLIM7 MUC16 24662828 2154892 Positive_regulation PDLIM7 TLR7 22952664 2683526 Positive_regulation PDLIM7 TLR7 22952664 2683527 Positive_regulation PDLIM7 TLR7 22952664 2683544 Positive_regulation PDLIM7 TLR7 22952664 2683545 Positive_regulation PDLIM7 TLR7 22952664 2683546 Positive_regulation PDLIM7 TLR7 22952664 2683549 Positive_regulation PDLIM7 TLR7 22952664 2683553 Positive_regulation PDLIM7 TLR7 22952664 2683554 Positive_regulation PDLIM7 TLR7 22952664 2683557 Positive_regulation PDLIM7 TLR7 22952664 2683558 Positive_regulation PDLIM7 TLR7 22952664 2683561 Positive_regulation PDLIM7 TLR7 22952664 2683562 Positive_regulation PDLIM7 TLR7 22952664 2683563 Positive_regulation PDLIM7 TNF 16573838 33382 Positive_regulation PDLIM7 TNF 20077016 92788 Positive_regulation PDLIM7 TNF 20077016 92800 Positive_regulation PDLIM7 TNF 24886620 3216280 Positive_regulation PDLIM7 TNFSF10 20077016 92793 Positive_regulation PDLIM7 TNFSF10 20077016 92812 Positive_regulation PDLIM7 TNFSF10 24633224 2934733 Positive_regulation PDLIM7 TNFSF10 24633224 2934734 Positive_regulation PDLIM7 TNFSF10 24633224 2934735 Positive_regulation PDLIM7 TNFSF10 24633224 2934747 Positive_regulation PDLIM7 TNFSF10 24633224 2934768 Positive_regulation PDP1 MAP2K6 19390590 2414877 Positive_regulation PDX1 EPHB2 19502418 708724 Positive_regulation PDX1 FOXO1 21209957 2492631 Positive_regulation PDX1 FOXO1 21537415 730255 Positive_regulation PDX1 FOXO1 21716694 831710 Positive_regulation PDX1 FOXO1 22563476 2626855 Positive_regulation PDX1 FOXO1 22577380 1072975 Positive_regulation PDX1 FOXO1 23372643 2745598 Positive_regulation PDX1 FOXO1 24594290 522476 Positive_regulation PDX1 PGC 23274887 725449 Positive_regulation PDZK1 HHIP 21653824 1791375 Positive_regulation PDZK1 HNF4A 24427299 2909381 Positive_regulation PDZK1 OATP1 24728453 2952061 Positive_regulation PDZK1 PPARA 20090896 1020653 Positive_regulation PDZK1 SCARB1 19654867 2422724 Positive_regulation PEA15 FOXO1 22281705 547809 Positive_regulation PECAM1 ABL1 23233201 1141349 Positive_regulation PECAM1 ABL1 23233201 1141350 Positive_regulation PECAM1 ABL1 23233201 1141351 Positive_regulation PECAM1 ABL1 23233201 1141365 Positive_regulation PECAM1 ALB 14960177 656394 Positive_regulation PECAM1 BCR 23233201 1141340 Positive_regulation PECAM1 BCR 23233201 1141341 Positive_regulation PECAM1 BCR 23233201 1141342 Positive_regulation PECAM1 BCR 23233201 1141362 Positive_regulation PECAM1 CCL2 22641100 1718345 Positive_regulation PECAM1 CCL2 22641100 1718346 Positive_regulation PECAM1 CCL2 22641100 1718347 Positive_regulation PECAM1 CCL2 22641100 1718348 Positive_regulation PECAM1 CCL2 22641100 1718358 Positive_regulation PECAM1 CCL2 22641100 1718362 Positive_regulation PECAM1 CCL2 22641100 1718363 Positive_regulation PECAM1 CCL2 22641100 1718372 Positive_regulation PECAM1 CCL2 22641100 1718373 Positive_regulation PECAM1 CCL2 22641100 1718374 Positive_regulation PECAM1 CCL2 22641100 1718375 Positive_regulation PECAM1 CCL2 22641100 1718382 Positive_regulation PECAM1 CCL2 22641100 1718386 Positive_regulation PECAM1 CCL2 22641100 1718387 Positive_regulation PECAM1 CCL2 22641100 1718394 Positive_regulation PECAM1 CCL2 22641100 1718395 Positive_regulation PECAM1 CCL2 22641100 1718399 Positive_regulation PECAM1 CCL2 23531482 857177 Positive_regulation PECAM1 CD27 23054369 1654676 Positive_regulation PECAM1 CD38 22720208 2160924 Positive_regulation PECAM1 CD38 23946809 2165403 Positive_regulation PECAM1 CD79A 23233201 1141343 Positive_regulation PECAM1 CD79A 23233201 1141344 Positive_regulation PECAM1 CD79A 23233201 1141345 Positive_regulation PECAM1 CD79A 23233201 1141363 Positive_regulation PECAM1 CD79B 23233201 1141346 Positive_regulation PECAM1 CD79B 23233201 1141347 Positive_regulation PECAM1 CD79B 23233201 1141348 Positive_regulation PECAM1 CD79B 23233201 1141364 Positive_regulation PECAM1 CDH1 22646479 336528 Positive_regulation PECAM1 CDH10 22646479 336529 Positive_regulation PECAM1 CDH11 22646479 336530 Positive_regulation PECAM1 CDH12 22646479 336531 Positive_regulation PECAM1 CDH13 22646479 336532 Positive_regulation PECAM1 CDH15 22646479 336533 Positive_regulation PECAM1 CDH16 22646479 336534 Positive_regulation PECAM1 CDH17 22646479 336535 Positive_regulation PECAM1 CDH18 22646479 336536 Positive_regulation PECAM1 CDH19 22646479 336537 Positive_regulation PECAM1 CDH2 22646479 336538 Positive_regulation PECAM1 CDH20 22646479 336539 Positive_regulation PECAM1 CDH22 22646479 336524 Positive_regulation PECAM1 CDH23 22646479 336525 Positive_regulation PECAM1 CDH24 22646479 336526 Positive_regulation PECAM1 CDH26 22646479 336527 Positive_regulation PECAM1 CDH3 22646479 336540 Positive_regulation PECAM1 CDH4 22646479 336541 Positive_regulation PECAM1 CDH5 22238515 846978 Positive_regulation PECAM1 CDH5 22646479 336542 Positive_regulation PECAM1 CDH6 22646479 336543 Positive_regulation PECAM1 CDH7 22646479 336544 Positive_regulation PECAM1 CDH8 22646479 336545 Positive_regulation PECAM1 CDH9 22646479 336546 Positive_regulation PECAM1 CSF3 22720040 2654013 Positive_regulation PECAM1 DROSHA 23637774 2785872 Positive_regulation PECAM1 EPO 17242961 810085 Positive_regulation PECAM1 FGF2 24052951 3165952 Positive_regulation PECAM1 FYN 18710921 1354894 Positive_regulation PECAM1 GATA2 18498633 323668 Positive_regulation PECAM1 HEY1 18663143 1354151 Positive_regulation PECAM1 HEY2 18663143 1354152 Positive_regulation PECAM1 HGF 23622716 1617867 Positive_regulation PECAM1 HGF 24052951 3165953 Positive_regulation PECAM1 IL6 22720040 2654014 Positive_regulation PECAM1 IL9 23819059 1150801 Positive_regulation PECAM1 ITGA4 1377224 1528782 Positive_regulation PECAM1 ITGAL 1377224 1528783 Positive_regulation PECAM1 ITGAM 22850671 771968 Positive_regulation PECAM1 ITGB1 1377224 1528784 Positive_regulation PECAM1 JAM3 25474593 3070366 Positive_regulation PECAM1 KDR 21789227 2538344 Positive_regulation PECAM1 KITLG 22720040 2654015 Positive_regulation PECAM1 KMT2A 22926525 2148339 Positive_regulation PECAM1 LIG1 10725328 1256594 Positive_regulation PECAM1 LIG3 10725328 1256595 Positive_regulation PECAM1 LIG4 10725328 1256596 Positive_regulation PECAM1 MAA 14960177 656395 Positive_regulation PECAM1 MBTPS1 24898615 1234117 Positive_regulation PECAM1 MYLIP 22191032 154599 Positive_regulation PECAM1 MYLIP 22646479 336547 Positive_regulation PECAM1 PACS2 21151997 2485785 Positive_regulation PECAM1 PRKCD 25084151 2994178 Positive_regulation PECAM1 PRKCE 25084151 2994179 Positive_regulation PECAM1 PTPN11 23233201 1141352 Positive_regulation PECAM1 PTPRC 23054369 1654677 Positive_regulation PECAM1 PTPRC 23409178 2753921 Positive_regulation PECAM1 RENBP 20682692 715821 Positive_regulation PECAM1 SELE 21872249 139262 Positive_regulation PECAM1 SMN1 20682692 715820 Positive_regulation PECAM1 SNAI2 18663143 1354150 Positive_regulation PECAM1 SRC 11927609 1280796 Positive_regulation PECAM1 SRC 18710921 1354888 Positive_regulation PECAM1 SRC 18710921 1354893 Positive_regulation PECAM1 SRC 22641100 1718349 Positive_regulation PECAM1 SRC 22641100 1718350 Positive_regulation PECAM1 SRC 22641100 1718351 Positive_regulation PECAM1 SRC 22641100 1718383 Positive_regulation PECAM1 SRC 22641100 1718390 Positive_regulation PECAM1 TBX5 12177047 1286362 Positive_regulation PECAM1 TLR4 24434316 1045861 Positive_regulation PECAM1 TNF 12930553 658492 Positive_regulation PECAM1 TNF 17242961 810074 Positive_regulation PECAM1 TNF 18466611 392137 Positive_regulation PECAM1 TNF 23398879 3210483 Positive_regulation PECAM1 TP53 16982804 1334081 Positive_regulation PECAM1 UTS2 24244812 204855 Positive_regulation PECAM1 VCAM1 21872249 139263 Positive_regulation PECAM1 VEGFA 17535968 1340540 Positive_regulation PECAM1 VEGFA 18710921 1354892 Positive_regulation PECAM1 VEGFA 24052951 3165951 Positive_regulation PECAM1 VEGFA 24429026 3169826 Positive_regulation PELI1 TLR7 19734906 1953066 Positive_regulation PER1 FAS 24068941 2349954 Positive_regulation PER1 RGS16 21610730 1933105 Positive_regulation PER1 RGS16 21610730 1933107 Positive_regulation PER1 TNF 24901009 1621712 Positive_regulation PGA3 PGC 12698190 422483 Positive_regulation PGA4 PGC 12698190 422484 Positive_regulation PGA5 PGC 12698190 422485 Positive_regulation PGC ACOT1 23226270 2724012 Positive_regulation PGC ADIPOQ 18560589 2391453 Positive_regulation PGC ADIPOQ 22415879 721903 Positive_regulation PGC ADIPOQ 22415879 721904 Positive_regulation PGC ADIPOQ 22415879 721905 Positive_regulation PGC ADIPOQ 22415879 722137 Positive_regulation PGC ADIPOQ 22415879 722138 Positive_regulation PGC ADIPOQ 22415879 722236 Positive_regulation PGC ADIPOQ 22415879 722280 Positive_regulation PGC ADIPOQ 22415879 722282 Positive_regulation PGC ADIPOQ 22415879 722378 Positive_regulation PGC ADIPOQ 22415879 722379 Positive_regulation PGC ADIPOQ 23238294 725378 Positive_regulation PGC ADIPOQ 24843438 1493212 Positive_regulation PGC ADIPOQ 25051362 2196770 Positive_regulation PGC ADIPOR1 21712952 2531439 Positive_regulation PGC ADIPOR1 24843438 1493260 Positive_regulation PGC ADO 24914683 2978947 Positive_regulation PGC AGO2 22655115 2224225 Positive_regulation PGC AGTR2 22013433 3075747 Positive_regulation PGC AHSA1 20847946 3075426 Positive_regulation PGC AHSA1 22415879 722235 Positive_regulation PGC AKT1 24675698 1125670 Positive_regulation PGC AKT2 21297943 2498631 Positive_regulation PGC ANGPTL3 25495645 216824 Positive_regulation PGC ANGPTL3 25495645 216853 Positive_regulation PGC ARNTL 20228939 26881 Positive_regulation PGC ARNTL 23990898 2840354 Positive_regulation PGC ATF2 19440340 2416800 Positive_regulation PGC ATF2 21629705 1155233 Positive_regulation PGC ATF6 23716639 2088900 Positive_regulation PGC ATG10 21887385 2549749 Positive_regulation PGC ATG12 21887385 2549752 Positive_regulation PGC ATG13 21887385 2549751 Positive_regulation PGC ATG14 21887385 2549748 Positive_regulation PGC ATG3 21887385 2549750 Positive_regulation PGC ATG5 21887385 2549753 Positive_regulation PGC ATG7 21887385 2549747 Positive_regulation PGC BAAT 23630518 878365 Positive_regulation PGC BMP1 19849841 302791 Positive_regulation PGC BMP10 19849841 302799 Positive_regulation PGC BMP15 19849841 302792 Positive_regulation PGC BMP2 19849841 302793 Positive_regulation PGC BMP3 19849841 302794 Positive_regulation PGC BMP4 19849841 302795 Positive_regulation PGC BMP4 24917499 704492 Positive_regulation PGC BMP4 25298745 3102623 Positive_regulation PGC BMP5 19849841 302796 Positive_regulation PGC BMP6 19849841 302797 Positive_regulation PGC BMP7 19849841 302798 Positive_regulation PGC CA2 20847946 3075380 Positive_regulation PGC CA2 20847946 3075427 Positive_regulation PGC CA2 22415879 722237 Positive_regulation PGC CA2 23166610 2718030 Positive_regulation PGC CA2 23536811 2773002 Positive_regulation PGC CA2 24843073 2252172 Positive_regulation PGC CALML3 25076854 1063208 Positive_regulation PGC CAMK1 20847946 3075428 Positive_regulation PGC CAMK4 20847946 3075429 Positive_regulation PGC CCNT1 22096235 2069569 Positive_regulation PGC CEBPA 19641492 1983871 Positive_regulation PGC CEBPA 19641492 1983873 Positive_regulation PGC CIDEC 18682832 2394921 Positive_regulation PGC COQ2 24091663 567312 Positive_regulation PGC COQ3 24091663 567308 Positive_regulation PGC COQ4 24091663 567309 Positive_regulation PGC COQ5 24091663 567314 Positive_regulation PGC COQ6 24091663 567310 Positive_regulation PGC COQ7 24091663 567311 Positive_regulation PGC COQ9 24091663 567313 Positive_regulation PGC CORO2A 23304112 3076131 Positive_regulation PGC CPT1B 19435887 1165974 Positive_regulation PGC CREB1 18487450 706064 Positive_regulation PGC CREB1 20157566 25965 Positive_regulation PGC CREB1 21533282 2515808 Positive_regulation PGC CREB1 21533282 2515818 Positive_regulation PGC CREB1 21542802 137814 Positive_regulation PGC CREB1 22035495 520090 Positive_regulation PGC CREB1 22315325 721507 Positive_regulation PGC CREB1 22693510 1068499 Positive_regulation PGC CREB1 22829833 1068697 Positive_regulation PGC CREB1 22888430 1155586 Positive_regulation PGC CREB1 23028378 2338680 Positive_regulation PGC CREB1 23110128 2706536 Positive_regulation PGC CREB1 24238363 221950 Positive_regulation PGC CREB3 18487450 706065 Positive_regulation PGC CREB3 20157566 25966 Positive_regulation PGC CREB3 21533282 2515809 Positive_regulation PGC CREB3 21533282 2515819 Positive_regulation PGC CREB3 21542802 137815 Positive_regulation PGC CREB3 22035495 520091 Positive_regulation PGC CREB3 22315325 721508 Positive_regulation PGC CREB3 22693510 1068500 Positive_regulation PGC CREB3 22829833 1068698 Positive_regulation PGC CREB3 22888430 1155587 Positive_regulation PGC CREB3 23028378 2338681 Positive_regulation PGC CREB3 23110128 2706537 Positive_regulation PGC CREB3 24238363 221951 Positive_regulation PGC CREB5 18487450 706063 Positive_regulation PGC CREB5 20157566 25964 Positive_regulation PGC CREB5 21533282 2515807 Positive_regulation PGC CREB5 21533282 2515817 Positive_regulation PGC CREB5 21542802 137813 Positive_regulation PGC CREB5 22035495 520089 Positive_regulation PGC CREB5 22315325 721506 Positive_regulation PGC CREB5 22693510 1068498 Positive_regulation PGC CREB5 22829833 1068696 Positive_regulation PGC CREB5 22888430 1155585 Positive_regulation PGC CREB5 23028378 2338679 Positive_regulation PGC CREB5 23110128 2706535 Positive_regulation PGC CREB5 24238363 221949 Positive_regulation PGC CRK 22548174 1155552 Positive_regulation PGC CRK 24843073 2252163 Positive_regulation PGC CRK 24843073 2252165 Positive_regulation PGC CRTC1 23242154 1100022 Positive_regulation PGC CRTC2 23028378 2338682 Positive_regulation PGC CRTC2 24238363 221952 Positive_regulation PGC CRTC2 24529027 3216222 Positive_regulation PGC CRTC2 24529027 3216223 Positive_regulation PGC CTBP1 22453831 1933618 Positive_regulation PGC CTBP1 22453831 1933636 Positive_regulation PGC CTDNEP1 23469192 2763025 Positive_regulation PGC CTDNEP1 23469192 2763120 Positive_regulation PGC CXCL12 23826390 2812505 Positive_regulation PGC CYCS 23145024 2715235 Positive_regulation PGC DGAT1 21264296 2495225 Positive_regulation PGC DIO1 23451284 2758546 Positive_regulation PGC DIO2 23451284 2758547 Positive_regulation PGC DIO3 23451284 2758548 Positive_regulation PGC DND1 23773267 316803 Positive_regulation PGC DUSP1 20375469 27145 Positive_regulation PGC DUSP1 22415879 721906 Positive_regulation PGC EPO 23990359 728515 Positive_regulation PGC EPO 25170305 1063334 Positive_regulation PGC EPO 25170305 1063346 Positive_regulation PGC EPO 25177095 175105 Positive_regulation PGC EPS15 20532042 2452247 Positive_regulation PGC EPS15 20532042 2452251 Positive_regulation PGC EPS15 20532042 2452253 Positive_regulation PGC EPS8 20532042 2452248 Positive_regulation PGC EPS8 20532042 2452252 Positive_regulation PGC EPS8 20532042 2452254 Positive_regulation PGC EPX 23990359 728510 Positive_regulation PGC EPX 23990359 728517 Positive_regulation PGC EPX 25170305 1063350 Positive_regulation PGC EPX 25170305 1063370 Positive_regulation PGC ERF 20713602 1378388 Positive_regulation PGC FAS 22676303 1724587 Positive_regulation PGC FAS 22676303 1724648 Positive_regulation PGC FBN2 20847946 3075430 Positive_regulation PGC FGF1 24917499 704112 Positive_regulation PGC FGF1 24917499 704493 Positive_regulation PGC FGF10 24917499 704113 Positive_regulation PGC FGF10 24917499 704494 Positive_regulation PGC FGF11 24917499 704114 Positive_regulation PGC FGF11 24917499 704495 Positive_regulation PGC FGF12 24917499 704115 Positive_regulation PGC FGF12 24917499 704496 Positive_regulation PGC FGF13 24917499 704116 Positive_regulation PGC FGF13 24917499 704497 Positive_regulation PGC FGF14 24917499 704117 Positive_regulation PGC FGF14 24917499 704498 Positive_regulation PGC FGF16 24917499 704118 Positive_regulation PGC FGF16 24917499 704499 Positive_regulation PGC FGF17 24917499 704119 Positive_regulation PGC FGF17 24917499 704500 Positive_regulation PGC FGF18 24917499 704120 Positive_regulation PGC FGF18 24917499 704501 Positive_regulation PGC FGF19 24917499 704121 Positive_regulation PGC FGF19 24917499 704502 Positive_regulation PGC FGF2 24917499 704122 Positive_regulation PGC FGF2 24917499 704503 Positive_regulation PGC FGF20 24917499 704123 Positive_regulation PGC FGF20 24917499 704504 Positive_regulation PGC FGF21 20730630 616142 Positive_regulation PGC FGF21 21331285 1669717 Positive_regulation PGC FGF21 23895241 213850 Positive_regulation PGC FGF21 23970879 879137 Positive_regulation PGC FGF21 24917499 704124 Positive_regulation PGC FGF21 24917499 704505 Positive_regulation PGC FGF22 24917499 704125 Positive_regulation PGC FGF22 24917499 704506 Positive_regulation PGC FGF23 24917499 704126 Positive_regulation PGC FGF23 24917499 704507 Positive_regulation PGC FGF3 24917499 704127 Positive_regulation PGC FGF3 24917499 704508 Positive_regulation PGC FGF4 24917499 704128 Positive_regulation PGC FGF4 24917499 704509 Positive_regulation PGC FGF5 24917499 704129 Positive_regulation PGC FGF5 24917499 704510 Positive_regulation PGC FGF6 24917499 704130 Positive_regulation PGC FGF6 24917499 704511 Positive_regulation PGC FGF7 24917499 704131 Positive_regulation PGC FGF7 24917499 704512 Positive_regulation PGC FGF8 24917499 704132 Positive_regulation PGC FGF8 24917499 704513 Positive_regulation PGC FGF9 24917499 704133 Positive_regulation PGC FGF9 24917499 704514 Positive_regulation PGC FNDC5 24666558 3114535 Positive_regulation PGC FNDC5 24725369 396472 Positive_regulation PGC FNDC5 24864142 1074137 Positive_regulation PGC FOXC2 18682832 2394920 Positive_regulation PGC FOXC2 21270254 717390 Positive_regulation PGC FOXC2 21270254 717397 Positive_regulation PGC FOXO1 17531095 2013454 Positive_regulation PGC FOXO1 23443131 1102677 Positive_regulation PGC FOXO1 23639108 213496 Positive_regulation PGC FOXO4 24983969 2985868 Positive_regulation PGC FOXO6 23639108 213494 Positive_regulation PGC FOXO6 23639108 213495 Positive_regulation PGC FOXO6 23639108 213509 Positive_regulation PGC FOXO6 23639108 213516 Positive_regulation PGC FXR1 23540496 648042 Positive_regulation PGC FXR2 23540496 648043 Positive_regulation PGC G6PC 23274887 725474 Positive_regulation PGC GAPDH 20972425 1925266 Positive_regulation PGC GATA1 18974883 2399611 Positive_regulation PGC GATA2 18974883 2399612 Positive_regulation PGC GATA3 18974883 2399613 Positive_regulation PGC GATA4 18974883 2399614 Positive_regulation PGC GATA4 18974883 2399644 Positive_regulation PGC GATA4 18974883 2399664 Positive_regulation PGC GATA5 18974883 2399610 Positive_regulation PGC GATA6 18974883 2399615 Positive_regulation PGC GCG 23166782 2718949 Positive_regulation PGC GCG 24147136 2870897 Positive_regulation PGC GCG 24189067 1208670 Positive_regulation PGC GDAP1L1 24480485 452244 Positive_regulation PGC GPS2 23304112 3076133 Positive_regulation PGC GRAP2 24843073 2252164 Positive_regulation PGC HDAC1 21731503 2324969 Positive_regulation PGC HDAC1 22453831 1933622 Positive_regulation PGC HDAC1 22453831 1933640 Positive_regulation PGC HDAC10 21731503 2324967 Positive_regulation PGC HDAC11 21731503 2324968 Positive_regulation PGC HDAC2 21731503 2324970 Positive_regulation PGC HDAC2 22453831 1933623 Positive_regulation PGC HDAC3 21731503 2324971 Positive_regulation PGC HDAC3 23304112 3076134 Positive_regulation PGC HDAC4 21731503 2324961 Positive_regulation PGC HDAC5 21731503 2324965 Positive_regulation PGC HDAC5 24027504 861020 Positive_regulation PGC HDAC6 21731503 2324962 Positive_regulation PGC HDAC7 21731503 2324964 Positive_regulation PGC HDAC8 21731503 2324960 Positive_regulation PGC HDAC9 21731503 2324963 Positive_regulation PGC HMG20A 22453831 1933624 Positive_regulation PGC HMG20A 22453831 1933641 Positive_regulation PGC HMG20B 22453831 1933625 Positive_regulation PGC HMG20B 22453831 1933642 Positive_regulation PGC HMOX1 22563483 2626894 Positive_regulation PGC HNF4A 22984287 1882653 Positive_regulation PGC HSPA1B 22453831 1933626 Positive_regulation PGC HSPA1B 22453831 1933643 Positive_regulation PGC HTT 22811764 2224551 Positive_regulation PGC IFITM1 18071348 429746 Positive_regulation PGC IFITM3 18071348 429747 Positive_regulation PGC IGF1 23755187 2801870 Positive_regulation PGC IL6 23240005 2727159 Positive_regulation PGC IL6 23240005 2727165 Positive_regulation PGC IL6 23240005 2727174 Positive_regulation PGC IL6 23240005 2727185 Positive_regulation PGC IL6 23240005 2727186 Positive_regulation PGC INS 19262749 2406889 Positive_regulation PGC INS 19274082 2407452 Positive_regulation PGC INS 19274082 2407453 Positive_regulation PGC INS 20573749 715357 Positive_regulation PGC INS 21629705 1155265 Positive_regulation PGC KAT2A 21629705 1155220 Positive_regulation PGC KAT2B 23434656 1101838 Positive_regulation PGC KAT2B 25566433 1498402 Positive_regulation PGC KDM1A 22453831 1933621 Positive_regulation PGC KDM1A 22453831 1933639 Positive_regulation PGC LEP 20532036 2452169 Positive_regulation PGC LEP 25514415 1135750 Positive_regulation PGC LPIN1 21857965 2544433 Positive_regulation PGC MAP2K3 24843073 2252129 Positive_regulation PGC MAP2K6 24843073 2252130 Positive_regulation PGC MAPK1 19936205 2431707 Positive_regulation PGC MAPK1 20847946 3075382 Positive_regulation PGC MAPK1 21629705 1155221 Positive_regulation PGC MAPK1 21629705 1155243 Positive_regulation PGC MAPK1 21629705 1155267 Positive_regulation PGC MAPK1 22175016 1686885 Positive_regulation PGC MAPK1 22415879 722142 Positive_regulation PGC MAPK1 22415879 722143 Positive_regulation PGC MAPK1 22415879 722144 Positive_regulation PGC MAPK1 22415879 722239 Positive_regulation PGC MAPK1 22500113 1223997 Positive_regulation PGC MAPK1 23050972 89654 Positive_regulation PGC MAPK1 23050972 89667 Positive_regulation PGC MAPK1 23093952 3076016 Positive_regulation PGC MAPK1 23093952 3076048 Positive_regulation PGC MAPK1 23554809 3076450 Positive_regulation PGC MAPK1 23874150 2283618 Positive_regulation PGC MAPK10 19936205 2431708 Positive_regulation PGC MAPK10 20847946 3075383 Positive_regulation PGC MAPK10 21629705 1155222 Positive_regulation PGC MAPK10 21629705 1155244 Positive_regulation PGC MAPK10 21629705 1155268 Positive_regulation PGC MAPK10 22175016 1686886 Positive_regulation PGC MAPK10 22415879 722145 Positive_regulation PGC MAPK10 22415879 722146 Positive_regulation PGC MAPK10 22415879 722147 Positive_regulation PGC MAPK10 22415879 722240 Positive_regulation PGC MAPK10 22500113 1223998 Positive_regulation PGC MAPK10 23050972 89655 Positive_regulation PGC MAPK10 23050972 89668 Positive_regulation PGC MAPK10 23093952 3076017 Positive_regulation PGC MAPK10 23093952 3076049 Positive_regulation PGC MAPK10 23554809 3076451 Positive_regulation PGC MAPK10 23874150 2283619 Positive_regulation PGC MAPK11 19936205 2431709 Positive_regulation PGC MAPK11 20847946 3075384 Positive_regulation PGC MAPK11 21629705 1155223 Positive_regulation PGC MAPK11 21629705 1155245 Positive_regulation PGC MAPK11 21629705 1155269 Positive_regulation PGC MAPK11 22175016 1686887 Positive_regulation PGC MAPK11 22415879 722148 Positive_regulation PGC MAPK11 22415879 722149 Positive_regulation PGC MAPK11 22415879 722150 Positive_regulation PGC MAPK11 22415879 722241 Positive_regulation PGC MAPK11 22500113 1223999 Positive_regulation PGC MAPK11 23050972 89656 Positive_regulation PGC MAPK11 23050972 89669 Positive_regulation PGC MAPK11 23093952 3076018 Positive_regulation PGC MAPK11 23093952 3076050 Positive_regulation PGC MAPK11 23554809 3076452 Positive_regulation PGC MAPK11 23874150 2283620 Positive_regulation PGC MAPK12 19936205 2431710 Positive_regulation PGC MAPK12 20847946 3075385 Positive_regulation PGC MAPK12 21629705 1155224 Positive_regulation PGC MAPK12 21629705 1155246 Positive_regulation PGC MAPK12 21629705 1155270 Positive_regulation PGC MAPK12 22175016 1686888 Positive_regulation PGC MAPK12 22415879 722151 Positive_regulation PGC MAPK12 22415879 722152 Positive_regulation PGC MAPK12 22415879 722153 Positive_regulation PGC MAPK12 22415879 722242 Positive_regulation PGC MAPK12 22500113 1224000 Positive_regulation PGC MAPK12 23050972 89657 Positive_regulation PGC MAPK12 23050972 89670 Positive_regulation PGC MAPK12 23093952 3076019 Positive_regulation PGC MAPK12 23093952 3076051 Positive_regulation PGC MAPK12 23554809 3076453 Positive_regulation PGC MAPK12 23874150 2283621 Positive_regulation PGC MAPK13 19936205 2431711 Positive_regulation PGC MAPK13 20847946 3075386 Positive_regulation PGC MAPK13 21629705 1155225 Positive_regulation PGC MAPK13 21629705 1155247 Positive_regulation PGC MAPK13 21629705 1155271 Positive_regulation PGC MAPK13 22175016 1686889 Positive_regulation PGC MAPK13 22415879 722154 Positive_regulation PGC MAPK13 22415879 722155 Positive_regulation PGC MAPK13 22415879 722156 Positive_regulation PGC MAPK13 22415879 722243 Positive_regulation PGC MAPK13 22500113 1224001 Positive_regulation PGC MAPK13 23050972 89658 Positive_regulation PGC MAPK13 23050972 89671 Positive_regulation PGC MAPK13 23093952 3076020 Positive_regulation PGC MAPK13 23093952 3076052 Positive_regulation PGC MAPK13 23554809 3076454 Positive_regulation PGC MAPK13 23874150 2283622 Positive_regulation PGC MAPK14 19936205 2431712 Positive_regulation PGC MAPK14 20847946 3075387 Positive_regulation PGC MAPK14 21629705 1155226 Positive_regulation PGC MAPK14 21629705 1155248 Positive_regulation PGC MAPK14 21629705 1155272 Positive_regulation PGC MAPK14 22175016 1686890 Positive_regulation PGC MAPK14 22415879 722157 Positive_regulation PGC MAPK14 22415879 722158 Positive_regulation PGC MAPK14 22415879 722159 Positive_regulation PGC MAPK14 22415879 722244 Positive_regulation PGC MAPK14 22500113 1224002 Positive_regulation PGC MAPK14 23050972 89659 Positive_regulation PGC MAPK14 23050972 89672 Positive_regulation PGC MAPK14 23093952 3076021 Positive_regulation PGC MAPK14 23093952 3076053 Positive_regulation PGC MAPK14 23554809 3076455 Positive_regulation PGC MAPK14 23874150 2283623 Positive_regulation PGC MAPK15 19936205 2431706 Positive_regulation PGC MAPK15 20847946 3075381 Positive_regulation PGC MAPK15 21629705 1155219 Positive_regulation PGC MAPK15 21629705 1155242 Positive_regulation PGC MAPK15 21629705 1155266 Positive_regulation PGC MAPK15 22175016 1686884 Positive_regulation PGC MAPK15 22415879 722139 Positive_regulation PGC MAPK15 22415879 722140 Positive_regulation PGC MAPK15 22415879 722141 Positive_regulation PGC MAPK15 22415879 722238 Positive_regulation PGC MAPK15 22500113 1223996 Positive_regulation PGC MAPK15 23050972 89653 Positive_regulation PGC MAPK15 23050972 89666 Positive_regulation PGC MAPK15 23093952 3076015 Positive_regulation PGC MAPK15 23093952 3076047 Positive_regulation PGC MAPK15 23554809 3076449 Positive_regulation PGC MAPK15 23874150 2283617 Positive_regulation PGC MAPK3 19936205 2431713 Positive_regulation PGC MAPK3 20847946 3075388 Positive_regulation PGC MAPK3 21629705 1155227 Positive_regulation PGC MAPK3 21629705 1155249 Positive_regulation PGC MAPK3 21629705 1155273 Positive_regulation PGC MAPK3 22175016 1686891 Positive_regulation PGC MAPK3 22415879 722160 Positive_regulation PGC MAPK3 22415879 722161 Positive_regulation PGC MAPK3 22415879 722162 Positive_regulation PGC MAPK3 22415879 722245 Positive_regulation PGC MAPK3 22500113 1224003 Positive_regulation PGC MAPK3 23050972 89660 Positive_regulation PGC MAPK3 23050972 89673 Positive_regulation PGC MAPK3 23093952 3076022 Positive_regulation PGC MAPK3 23093952 3076054 Positive_regulation PGC MAPK3 23554809 3076456 Positive_regulation PGC MAPK3 23874150 2283624 Positive_regulation PGC MAPK4 19936205 2431714 Positive_regulation PGC MAPK4 20847946 3075389 Positive_regulation PGC MAPK4 21629705 1155228 Positive_regulation PGC MAPK4 21629705 1155250 Positive_regulation PGC MAPK4 21629705 1155274 Positive_regulation PGC MAPK4 22175016 1686892 Positive_regulation PGC MAPK4 22415879 722163 Positive_regulation PGC MAPK4 22415879 722164 Positive_regulation PGC MAPK4 22415879 722165 Positive_regulation PGC MAPK4 22415879 722246 Positive_regulation PGC MAPK4 22500113 1224004 Positive_regulation PGC MAPK4 23050972 89661 Positive_regulation PGC MAPK4 23050972 89674 Positive_regulation PGC MAPK4 23093952 3076023 Positive_regulation PGC MAPK4 23093952 3076055 Positive_regulation PGC MAPK4 23554809 3076457 Positive_regulation PGC MAPK4 23874150 2283625 Positive_regulation PGC MAPK6 19936205 2431715 Positive_regulation PGC MAPK6 20847946 3075390 Positive_regulation PGC MAPK6 21629705 1155229 Positive_regulation PGC MAPK6 21629705 1155251 Positive_regulation PGC MAPK6 21629705 1155275 Positive_regulation PGC MAPK6 22175016 1686893 Positive_regulation PGC MAPK6 22415879 722166 Positive_regulation PGC MAPK6 22415879 722167 Positive_regulation PGC MAPK6 22415879 722168 Positive_regulation PGC MAPK6 22415879 722247 Positive_regulation PGC MAPK6 22500113 1224005 Positive_regulation PGC MAPK6 23050972 89662 Positive_regulation PGC MAPK6 23050972 89675 Positive_regulation PGC MAPK6 23093952 3076024 Positive_regulation PGC MAPK6 23093952 3076056 Positive_regulation PGC MAPK6 23554809 3076458 Positive_regulation PGC MAPK6 23874150 2283626 Positive_regulation PGC MAPK7 19936205 2431716 Positive_regulation PGC MAPK7 20847946 3075391 Positive_regulation PGC MAPK7 21629705 1155230 Positive_regulation PGC MAPK7 21629705 1155252 Positive_regulation PGC MAPK7 21629705 1155276 Positive_regulation PGC MAPK7 22175016 1686894 Positive_regulation PGC MAPK7 22415879 722169 Positive_regulation PGC MAPK7 22415879 722170 Positive_regulation PGC MAPK7 22415879 722171 Positive_regulation PGC MAPK7 22415879 722248 Positive_regulation PGC MAPK7 22500113 1224006 Positive_regulation PGC MAPK7 23050972 89663 Positive_regulation PGC MAPK7 23050972 89676 Positive_regulation PGC MAPK7 23093952 3076025 Positive_regulation PGC MAPK7 23093952 3076057 Positive_regulation PGC MAPK7 23554809 3076459 Positive_regulation PGC MAPK7 23874150 2283627 Positive_regulation PGC MAPK8 19936205 2431717 Positive_regulation PGC MAPK8 20847946 3075392 Positive_regulation PGC MAPK8 21629705 1155231 Positive_regulation PGC MAPK8 21629705 1155253 Positive_regulation PGC MAPK8 21629705 1155277 Positive_regulation PGC MAPK8 22175016 1686895 Positive_regulation PGC MAPK8 22415879 722172 Positive_regulation PGC MAPK8 22415879 722173 Positive_regulation PGC MAPK8 22415879 722174 Positive_regulation PGC MAPK8 22415879 722249 Positive_regulation PGC MAPK8 22500113 1224007 Positive_regulation PGC MAPK8 23050972 89664 Positive_regulation PGC MAPK8 23050972 89677 Positive_regulation PGC MAPK8 23093952 3076026 Positive_regulation PGC MAPK8 23093952 3076058 Positive_regulation PGC MAPK8 23554809 3076460 Positive_regulation PGC MAPK8 23874150 2283628 Positive_regulation PGC MAPK9 19936205 2431718 Positive_regulation PGC MAPK9 20847946 3075393 Positive_regulation PGC MAPK9 21629705 1155232 Positive_regulation PGC MAPK9 21629705 1155254 Positive_regulation PGC MAPK9 21629705 1155278 Positive_regulation PGC MAPK9 22175016 1686896 Positive_regulation PGC MAPK9 22415879 722175 Positive_regulation PGC MAPK9 22415879 722176 Positive_regulation PGC MAPK9 22415879 722177 Positive_regulation PGC MAPK9 22415879 722250 Positive_regulation PGC MAPK9 22500113 1224008 Positive_regulation PGC MAPK9 23050972 89665 Positive_regulation PGC MAPK9 23050972 89678 Positive_regulation PGC MAPK9 23093952 3076027 Positive_regulation PGC MAPK9 23093952 3076059 Positive_regulation PGC MAPK9 23554809 3076461 Positive_regulation PGC MAPK9 23874150 2283629 Positive_regulation PGC MARK1 25057490 195428 Positive_regulation PGC MARK2 25057490 195427 Positive_regulation PGC MARK3 25057490 195429 Positive_regulation PGC MARK4 25057490 195426 Positive_regulation PGC MB 23687941 1653617 Positive_regulation PGC MB 24145055 829858 Positive_regulation PGC MEFV 19440340 2416799 Positive_regulation PGC MEFV 23250358 725419 Positive_regulation PGC MEFV 24027504 861021 Positive_regulation PGC MFN1 22246294 1033617 Positive_regulation PGC MFN1 24642777 2935255 Positive_regulation PGC MFN2 18974884 2399746 Positive_regulation PGC MFN2 18974884 2399747 Positive_regulation PGC MFN2 18974884 2399756 Positive_regulation PGC MFN2 22246294 1033616 Positive_regulation PGC MFN2 24642777 2935254 Positive_regulation PGC MFN2 24898700 1483519 Positive_regulation PGC MIF 23823021 1497758 Positive_regulation PGC MITF 24350057 946721 Positive_regulation PGC MITF 24350057 946784 Positive_regulation PGC MITF 24743024 2189227 Positive_regulation PGC MLST8 25166345 2301353 Positive_regulation PGC MSH6 22548174 1155569 Positive_regulation PGC MT-CO2 23166610 2718031 Positive_regulation PGC MT-CO2 23166610 2718032 Positive_regulation PGC MTOR 22351927 1395772 Positive_regulation PGC MTOR 22771762 842571 Positive_regulation PGC MTOR 23434656 1101869 Positive_regulation PGC MTOR 25166345 2301355 Positive_regulation PGC MYC 19779629 2427291 Positive_regulation PGC MYLIP 19440340 2416801 Positive_regulation PGC MYLIP 20739924 1903678 Positive_regulation PGC MYLIP 24705162 985142 Positive_regulation PGC NCOA3 22829833 1068715 Positive_regulation PGC NCOR1 23304112 3076135 Positive_regulation PGC NCOR2 23304112 3076136 Positive_regulation PGC NFE2L2 24077237 2118268 Positive_regulation PGC NOS3 25170305 1063330 Positive_regulation PGC NPS 19690065 710942 Positive_regulation PGC NPS 19690065 710943 Positive_regulation PGC NRD1 24492630 1940585 Positive_regulation PGC NRD1 24492630 1940586 Positive_regulation PGC NRD1 24492630 1940587 Positive_regulation PGC NRD1 24492630 1940594 Positive_regulation PGC NRD1 24492630 1940609 Positive_regulation PGC NRF1 22655115 2224226 Positive_regulation PGC NRIP1 20107496 2438303 Positive_regulation PGC OED 22989629 788660 Positive_regulation PGC OPN1LW 21533282 2515820 Positive_regulation PGC OPN1LW 23028378 2338683 Positive_regulation PGC OPN1LW 23549795 3233064 Positive_regulation PGC PDK4 19435887 1165975 Positive_regulation PGC PDK4 22682013 2113233 Positive_regulation PGC PDK4 24520982 2113983 Positive_regulation PGC PDK4 24520982 2113988 Positive_regulation PGC PGA3 12698190 422486 Positive_regulation PGC PGA4 12698190 422487 Positive_regulation PGC PGA5 12698190 422488 Positive_regulation PGC PHF21A 22453831 1933617 Positive_regulation PGC PHF21A 22453831 1933635 Positive_regulation PGC PHF21B 22453831 1933619 Positive_regulation PGC PHF21B 22453831 1933637 Positive_regulation PGC PI3 24675698 1125671 Positive_regulation PGC PLAC8 25566433 1498401 Positive_regulation PGC PLIN1 25610428 881539 Positive_regulation PGC POU5F1 21547058 1057111 Positive_regulation PGC PPARA 21723506 590229 Positive_regulation PGC PPARA 21723506 590231 Positive_regulation PGC PPARA 24086613 2855021 Positive_regulation PGC PPP3CA 21040371 174563 Positive_regulation PGC PPP3CA 23755172 2801578 Positive_regulation PGC PPP3CA 23755172 2801580 Positive_regulation PGC PPP3CB 21040371 174564 Positive_regulation PGC PPP3CC 21040371 174565 Positive_regulation PGC PPP3R1 23755172 2801579 Positive_regulation PGC PPP3R1 23755172 2801581 Positive_regulation PGC PRDM16 19641492 1983870 Positive_regulation PGC PRDM16 19641492 1983872 Positive_regulation PGC PRDM16 23990359 728506 Positive_regulation PGC PRDX3 23145024 2715236 Positive_regulation PGC PRKAA1 18431490 2387726 Positive_regulation PGC PRKAA1 18560589 2391483 Positive_regulation PGC PRKAA1 18974883 2399616 Positive_regulation PGC PRKAA1 18974883 2399636 Positive_regulation PGC PRKAA1 18974883 2399728 Positive_regulation PGC PRKAA1 19333447 1088182 Positive_regulation PGC PRKAA1 19366864 708319 Positive_regulation PGC PRKAA1 19366864 708331 Positive_regulation PGC PRKAA1 19730740 2425818 Positive_regulation PGC PRKAA1 19934007 711935 Positive_regulation PGC PRKAA1 20157566 25967 Positive_regulation PGC PRKAA1 20190133 712974 Positive_regulation PGC PRKAA1 20338882 2052662 Positive_regulation PGC PRKAA1 20383327 2445888 Positive_regulation PGC PRKAA1 20383327 2445894 Positive_regulation PGC PRKAA1 20847946 3075185 Positive_regulation PGC PRKAA1 21040371 174494 Positive_regulation PGC PRKAA1 21431325 1644387 Positive_regulation PGC PRKAA1 21483791 2512212 Positive_regulation PGC PRKAA1 21629705 1155234 Positive_regulation PGC PRKAA1 21723506 590223 Positive_regulation PGC PRKAA1 21768291 1389988 Positive_regulation PGC PRKAA1 21887385 2549838 Positive_regulation PGC PRKAA1 22175013 1686842 Positive_regulation PGC PRKAA1 22175016 1686897 Positive_regulation PGC PRKAA1 22203837 832452 Positive_regulation PGC PRKAA1 22359576 2597763 Positive_regulation PGC PRKAA1 22500113 1223990 Positive_regulation PGC PRKAA1 22548174 1155553 Positive_regulation PGC PRKAA1 22808092 2664285 Positive_regulation PGC PRKAA1 22808092 2664298 Positive_regulation PGC PRKAA1 22829833 1068716 Positive_regulation PGC PRKAA1 22829833 1068717 Positive_regulation PGC PRKAA1 22829833 1068718 Positive_regulation PGC PRKAA1 22837722 1096655 Positive_regulation PGC PRKAA1 22837722 1096661 Positive_regulation PGC PRKAA1 22919323 3153783 Positive_regulation PGC PRKAA1 23137106 509379 Positive_regulation PGC PRKAA1 23242154 1100011 Positive_regulation PGC PRKAA1 23250358 725420 Positive_regulation PGC PRKAA1 23272147 2729765 Positive_regulation PGC PRKAA1 23434656 1101841 Positive_regulation PGC PRKAA1 23738041 2226050 Positive_regulation PGC PRKAA1 23738041 2226056 Positive_regulation PGC PRKAA1 23738041 2226064 Positive_regulation PGC PRKAA1 23755172 2801611 Positive_regulation PGC PRKAA1 23861927 2820853 Positive_regulation PGC PRKAA1 23861927 2820860 Positive_regulation PGC PRKAA1 23874150 2283630 Positive_regulation PGC PRKAA1 23874150 2283658 Positive_regulation PGC PRKAA1 23874150 2283666 Positive_regulation PGC PRKAA1 23874150 2283684 Positive_regulation PGC PRKAA1 23874150 2283720 Positive_regulation PGC PRKAA1 23874150 2283727 Positive_regulation PGC PRKAA1 24070020 1869751 Positive_regulation PGC PRKAA1 24265619 962945 Positive_regulation PGC PRKAA1 24296486 31728 Positive_regulation PGC PRKAA1 24296486 31802 Positive_regulation PGC PRKAA1 24296486 31857 Positive_regulation PGC PRKAA1 24296486 31869 Positive_regulation PGC PRKAA1 24624081 858841 Positive_regulation PGC PRKAA1 24801481 2961392 Positive_regulation PGC PRKAA1 24801481 2961393 Positive_regulation PGC PRKAA1 24801481 2961411 Positive_regulation PGC PRKAA1 24843073 2252133 Positive_regulation PGC PRKAA1 24843073 2252145 Positive_regulation PGC PRKAA1 24843073 2252157 Positive_regulation PGC PRKAA1 24843073 2252166 Positive_regulation PGC PRKAA1 24843427 1493147 Positive_regulation PGC PRKAA1 25002755 1760042 Positive_regulation PGC PRKAA1 25057490 195430 Positive_regulation PGC PRKAA1 25061561 1888285 Positive_regulation PGC PRKAA1 25152028 19603 Positive_regulation PGC PRKAA1 25152028 19604 Positive_regulation PGC PRKAA1 25166345 2301397 Positive_regulation PGC PRKAA1 25221554 914027 Positive_regulation PGC PRKAA1 25371775 2230191 Positive_regulation PGC PRKAA1 25400942 1670060 Positive_regulation PGC PRKAA1 25484869 967150 Positive_regulation PGC PRKAA1 25566462 1498477 Positive_regulation PGC PRKAA1 25625009 3163473 Positive_regulation PGC PRKAA2 18431490 2387727 Positive_regulation PGC PRKAA2 18560589 2391484 Positive_regulation PGC PRKAA2 18974883 2399617 Positive_regulation PGC PRKAA2 18974883 2399637 Positive_regulation PGC PRKAA2 18974883 2399729 Positive_regulation PGC PRKAA2 19333447 1088183 Positive_regulation PGC PRKAA2 19366864 708320 Positive_regulation PGC PRKAA2 19366864 708332 Positive_regulation PGC PRKAA2 19730740 2425819 Positive_regulation PGC PRKAA2 19934007 711936 Positive_regulation PGC PRKAA2 20157566 25968 Positive_regulation PGC PRKAA2 20190133 712975 Positive_regulation PGC PRKAA2 20338882 2052663 Positive_regulation PGC PRKAA2 20383327 2445889 Positive_regulation PGC PRKAA2 20383327 2445895 Positive_regulation PGC PRKAA2 20847946 3075186 Positive_regulation PGC PRKAA2 21040371 174495 Positive_regulation PGC PRKAA2 21431325 1644388 Positive_regulation PGC PRKAA2 21483791 2512213 Positive_regulation PGC PRKAA2 21629705 1155235 Positive_regulation PGC PRKAA2 21723506 590224 Positive_regulation PGC PRKAA2 21768291 1389989 Positive_regulation PGC PRKAA2 21887385 2549839 Positive_regulation PGC PRKAA2 22175013 1686843 Positive_regulation PGC PRKAA2 22175016 1686898 Positive_regulation PGC PRKAA2 22203837 832453 Positive_regulation PGC PRKAA2 22359576 2597764 Positive_regulation PGC PRKAA2 22500113 1223991 Positive_regulation PGC PRKAA2 22548174 1155554 Positive_regulation PGC PRKAA2 22808092 2664286 Positive_regulation PGC PRKAA2 22808092 2664299 Positive_regulation PGC PRKAA2 22829833 1068719 Positive_regulation PGC PRKAA2 22829833 1068720 Positive_regulation PGC PRKAA2 22829833 1068721 Positive_regulation PGC PRKAA2 22837722 1096656 Positive_regulation PGC PRKAA2 22837722 1096662 Positive_regulation PGC PRKAA2 22919323 3153784 Positive_regulation PGC PRKAA2 23137106 509380 Positive_regulation PGC PRKAA2 23242154 1100012 Positive_regulation PGC PRKAA2 23250358 725421 Positive_regulation PGC PRKAA2 23272147 2729766 Positive_regulation PGC PRKAA2 23434656 1101842 Positive_regulation PGC PRKAA2 23738041 2226051 Positive_regulation PGC PRKAA2 23738041 2226057 Positive_regulation PGC PRKAA2 23738041 2226065 Positive_regulation PGC PRKAA2 23755172 2801612 Positive_regulation PGC PRKAA2 23861927 2820854 Positive_regulation PGC PRKAA2 23861927 2820861 Positive_regulation PGC PRKAA2 23874150 2283631 Positive_regulation PGC PRKAA2 23874150 2283659 Positive_regulation PGC PRKAA2 23874150 2283667 Positive_regulation PGC PRKAA2 23874150 2283685 Positive_regulation PGC PRKAA2 23874150 2283721 Positive_regulation PGC PRKAA2 23874150 2283728 Positive_regulation PGC PRKAA2 24070020 1869752 Positive_regulation PGC PRKAA2 24265619 962946 Positive_regulation PGC PRKAA2 24296486 31729 Positive_regulation PGC PRKAA2 24296486 31803 Positive_regulation PGC PRKAA2 24296486 31858 Positive_regulation PGC PRKAA2 24296486 31870 Positive_regulation PGC PRKAA2 24624081 858842 Positive_regulation PGC PRKAA2 24801481 2961394 Positive_regulation PGC PRKAA2 24801481 2961395 Positive_regulation PGC PRKAA2 24801481 2961412 Positive_regulation PGC PRKAA2 24843073 2252134 Positive_regulation PGC PRKAA2 24843073 2252146 Positive_regulation PGC PRKAA2 24843073 2252158 Positive_regulation PGC PRKAA2 24843073 2252167 Positive_regulation PGC PRKAA2 24843427 1493148 Positive_regulation PGC PRKAA2 25002755 1760043 Positive_regulation PGC PRKAA2 25057490 195431 Positive_regulation PGC PRKAA2 25061561 1888286 Positive_regulation PGC PRKAA2 25152028 19605 Positive_regulation PGC PRKAA2 25152028 19606 Positive_regulation PGC PRKAA2 25166345 2301398 Positive_regulation PGC PRKAA2 25221554 914028 Positive_regulation PGC PRKAA2 25371775 2230192 Positive_regulation PGC PRKAA2 25400942 1670061 Positive_regulation PGC PRKAA2 25484869 967151 Positive_regulation PGC PRKAA2 25566462 1498478 Positive_regulation PGC PRKAA2 25625009 3163474 Positive_regulation PGC PRKAB1 18431490 2387728 Positive_regulation PGC PRKAB1 18560589 2391485 Positive_regulation PGC PRKAB1 18974883 2399618 Positive_regulation PGC PRKAB1 18974883 2399638 Positive_regulation PGC PRKAB1 18974883 2399730 Positive_regulation PGC PRKAB1 19333447 1088184 Positive_regulation PGC PRKAB1 19366864 708321 Positive_regulation PGC PRKAB1 19366864 708333 Positive_regulation PGC PRKAB1 19730740 2425820 Positive_regulation PGC PRKAB1 19934007 711937 Positive_regulation PGC PRKAB1 20157566 25969 Positive_regulation PGC PRKAB1 20190133 712976 Positive_regulation PGC PRKAB1 20338882 2052664 Positive_regulation PGC PRKAB1 20383327 2445890 Positive_regulation PGC PRKAB1 20383327 2445896 Positive_regulation PGC PRKAB1 20847946 3075187 Positive_regulation PGC PRKAB1 21040371 174496 Positive_regulation PGC PRKAB1 21431325 1644389 Positive_regulation PGC PRKAB1 21483791 2512214 Positive_regulation PGC PRKAB1 21629705 1155236 Positive_regulation PGC PRKAB1 21723506 590225 Positive_regulation PGC PRKAB1 21768291 1389990 Positive_regulation PGC PRKAB1 21887385 2549840 Positive_regulation PGC PRKAB1 22175013 1686844 Positive_regulation PGC PRKAB1 22175016 1686899 Positive_regulation PGC PRKAB1 22203837 832454 Positive_regulation PGC PRKAB1 22359576 2597765 Positive_regulation PGC PRKAB1 22500113 1223992 Positive_regulation PGC PRKAB1 22548174 1155555 Positive_regulation PGC PRKAB1 22808092 2664287 Positive_regulation PGC PRKAB1 22808092 2664300 Positive_regulation PGC PRKAB1 22829833 1068722 Positive_regulation PGC PRKAB1 22829833 1068723 Positive_regulation PGC PRKAB1 22829833 1068724 Positive_regulation PGC PRKAB1 22837722 1096657 Positive_regulation PGC PRKAB1 22837722 1096663 Positive_regulation PGC PRKAB1 22919323 3153785 Positive_regulation PGC PRKAB1 23137106 509381 Positive_regulation PGC PRKAB1 23242154 1100013 Positive_regulation PGC PRKAB1 23250358 725422 Positive_regulation PGC PRKAB1 23272147 2729767 Positive_regulation PGC PRKAB1 23434656 1101843 Positive_regulation PGC PRKAB1 23738041 2226052 Positive_regulation PGC PRKAB1 23738041 2226058 Positive_regulation PGC PRKAB1 23738041 2226066 Positive_regulation PGC PRKAB1 23755172 2801613 Positive_regulation PGC PRKAB1 23861927 2820855 Positive_regulation PGC PRKAB1 23861927 2820862 Positive_regulation PGC PRKAB1 23874150 2283632 Positive_regulation PGC PRKAB1 23874150 2283660 Positive_regulation PGC PRKAB1 23874150 2283668 Positive_regulation PGC PRKAB1 23874150 2283686 Positive_regulation PGC PRKAB1 23874150 2283722 Positive_regulation PGC PRKAB1 23874150 2283729 Positive_regulation PGC PRKAB1 24070020 1869753 Positive_regulation PGC PRKAB1 24265619 962947 Positive_regulation PGC PRKAB1 24296486 31730 Positive_regulation PGC PRKAB1 24296486 31804 Positive_regulation PGC PRKAB1 24296486 31859 Positive_regulation PGC PRKAB1 24296486 31871 Positive_regulation PGC PRKAB1 24624081 858843 Positive_regulation PGC PRKAB1 24801481 2961396 Positive_regulation PGC PRKAB1 24801481 2961397 Positive_regulation PGC PRKAB1 24801481 2961413 Positive_regulation PGC PRKAB1 24843073 2252135 Positive_regulation PGC PRKAB1 24843073 2252147 Positive_regulation PGC PRKAB1 24843073 2252159 Positive_regulation PGC PRKAB1 24843073 2252168 Positive_regulation PGC PRKAB1 24843427 1493149 Positive_regulation PGC PRKAB1 25002755 1760044 Positive_regulation PGC PRKAB1 25057490 195432 Positive_regulation PGC PRKAB1 25061561 1888287 Positive_regulation PGC PRKAB1 25152028 19607 Positive_regulation PGC PRKAB1 25152028 19608 Positive_regulation PGC PRKAB1 25166345 2301399 Positive_regulation PGC PRKAB1 25221554 914029 Positive_regulation PGC PRKAB1 25371775 2230193 Positive_regulation PGC PRKAB1 25400942 1670062 Positive_regulation PGC PRKAB1 25484869 967152 Positive_regulation PGC PRKAB1 25566462 1498479 Positive_regulation PGC PRKAB1 25625009 3163475 Positive_regulation PGC PRKAB2 18431490 2387729 Positive_regulation PGC PRKAB2 18560589 2391486 Positive_regulation PGC PRKAB2 18974883 2399619 Positive_regulation PGC PRKAB2 18974883 2399639 Positive_regulation PGC PRKAB2 18974883 2399731 Positive_regulation PGC PRKAB2 19333447 1088185 Positive_regulation PGC PRKAB2 19366864 708322 Positive_regulation PGC PRKAB2 19366864 708334 Positive_regulation PGC PRKAB2 19730740 2425821 Positive_regulation PGC PRKAB2 19934007 711938 Positive_regulation PGC PRKAB2 20157566 25970 Positive_regulation PGC PRKAB2 20190133 712977 Positive_regulation PGC PRKAB2 20338882 2052665 Positive_regulation PGC PRKAB2 20383327 2445891 Positive_regulation PGC PRKAB2 20383327 2445897 Positive_regulation PGC PRKAB2 20847946 3075188 Positive_regulation PGC PRKAB2 21040371 174497 Positive_regulation PGC PRKAB2 21431325 1644390 Positive_regulation PGC PRKAB2 21483791 2512215 Positive_regulation PGC PRKAB2 21629705 1155237 Positive_regulation PGC PRKAB2 21723506 590226 Positive_regulation PGC PRKAB2 21768291 1389991 Positive_regulation PGC PRKAB2 21887385 2549841 Positive_regulation PGC PRKAB2 22175013 1686845 Positive_regulation PGC PRKAB2 22175016 1686900 Positive_regulation PGC PRKAB2 22203837 832455 Positive_regulation PGC PRKAB2 22359576 2597766 Positive_regulation PGC PRKAB2 22500113 1223993 Positive_regulation PGC PRKAB2 22548174 1155556 Positive_regulation PGC PRKAB2 22808092 2664288 Positive_regulation PGC PRKAB2 22808092 2664301 Positive_regulation PGC PRKAB2 22829833 1068725 Positive_regulation PGC PRKAB2 22829833 1068726 Positive_regulation PGC PRKAB2 22829833 1068727 Positive_regulation PGC PRKAB2 22837722 1096658 Positive_regulation PGC PRKAB2 22837722 1096664 Positive_regulation PGC PRKAB2 22919323 3153786 Positive_regulation PGC PRKAB2 23137106 509382 Positive_regulation PGC PRKAB2 23242154 1100014 Positive_regulation PGC PRKAB2 23250358 725423 Positive_regulation PGC PRKAB2 23272147 2729768 Positive_regulation PGC PRKAB2 23434656 1101844 Positive_regulation PGC PRKAB2 23738041 2226053 Positive_regulation PGC PRKAB2 23738041 2226059 Positive_regulation PGC PRKAB2 23738041 2226067 Positive_regulation PGC PRKAB2 23755172 2801614 Positive_regulation PGC PRKAB2 23861927 2820856 Positive_regulation PGC PRKAB2 23861927 2820863 Positive_regulation PGC PRKAB2 23874150 2283633 Positive_regulation PGC PRKAB2 23874150 2283661 Positive_regulation PGC PRKAB2 23874150 2283669 Positive_regulation PGC PRKAB2 23874150 2283687 Positive_regulation PGC PRKAB2 23874150 2283723 Positive_regulation PGC PRKAB2 23874150 2283730 Positive_regulation PGC PRKAB2 24070020 1869754 Positive_regulation PGC PRKAB2 24265619 962948 Positive_regulation PGC PRKAB2 24296486 31731 Positive_regulation PGC PRKAB2 24296486 31805 Positive_regulation PGC PRKAB2 24296486 31860 Positive_regulation PGC PRKAB2 24296486 31872 Positive_regulation PGC PRKAB2 24624081 858844 Positive_regulation PGC PRKAB2 24801481 2961398 Positive_regulation PGC PRKAB2 24801481 2961399 Positive_regulation PGC PRKAB2 24801481 2961414 Positive_regulation PGC PRKAB2 24843073 2252136 Positive_regulation PGC PRKAB2 24843073 2252148 Positive_regulation PGC PRKAB2 24843073 2252160 Positive_regulation PGC PRKAB2 24843073 2252169 Positive_regulation PGC PRKAB2 24843427 1493150 Positive_regulation PGC PRKAB2 25002755 1760045 Positive_regulation PGC PRKAB2 25057490 195433 Positive_regulation PGC PRKAB2 25061561 1888288 Positive_regulation PGC PRKAB2 25152028 19609 Positive_regulation PGC PRKAB2 25152028 19610 Positive_regulation PGC PRKAB2 25166345 2301400 Positive_regulation PGC PRKAB2 25221554 914030 Positive_regulation PGC PRKAB2 25371775 2230194 Positive_regulation PGC PRKAB2 25400942 1670063 Positive_regulation PGC PRKAB2 25484869 967153 Positive_regulation PGC PRKAB2 25566462 1498480 Positive_regulation PGC PRKAB2 25625009 3163476 Positive_regulation PGC PRKACB 22500113 1223982 Positive_regulation PGC PRKACB 22500113 1224021 Positive_regulation PGC PRKACB 22500113 1224039 Positive_regulation PGC PRKACB 23093952 3076061 Positive_regulation PGC PRKACB 23110128 2706538 Positive_regulation PGC PRKACB 23554809 3076652 Positive_regulation PGC PRKACB 24642777 2935256 Positive_regulation PGC PRKACG 22500113 1223983 Positive_regulation PGC PRKACG 22500113 1224022 Positive_regulation PGC PRKACG 22500113 1224040 Positive_regulation PGC PRKACG 23093952 3076062 Positive_regulation PGC PRKACG 23110128 2706539 Positive_regulation PGC PRKACG 23554809 3076653 Positive_regulation PGC PRKACG 24642777 2935257 Positive_regulation PGC PRKAG1 18431490 2387730 Positive_regulation PGC PRKAG1 18560589 2391487 Positive_regulation PGC PRKAG1 18974883 2399620 Positive_regulation PGC PRKAG1 18974883 2399640 Positive_regulation PGC PRKAG1 18974883 2399732 Positive_regulation PGC PRKAG1 19333447 1088186 Positive_regulation PGC PRKAG1 19366864 708323 Positive_regulation PGC PRKAG1 19366864 708335 Positive_regulation PGC PRKAG1 19730740 2425822 Positive_regulation PGC PRKAG1 19934007 711939 Positive_regulation PGC PRKAG1 20157566 25971 Positive_regulation PGC PRKAG1 20190133 712978 Positive_regulation PGC PRKAG1 20338882 2052666 Positive_regulation PGC PRKAG1 20383327 2445892 Positive_regulation PGC PRKAG1 20383327 2445898 Positive_regulation PGC PRKAG1 20847946 3075189 Positive_regulation PGC PRKAG1 21040371 174498 Positive_regulation PGC PRKAG1 21431325 1644391 Positive_regulation PGC PRKAG1 21483791 2512216 Positive_regulation PGC PRKAG1 21629705 1155238 Positive_regulation PGC PRKAG1 21723506 590227 Positive_regulation PGC PRKAG1 21768291 1389992 Positive_regulation PGC PRKAG1 21887385 2549842 Positive_regulation PGC PRKAG1 22175013 1686846 Positive_regulation PGC PRKAG1 22175016 1686901 Positive_regulation PGC PRKAG1 22203837 832456 Positive_regulation PGC PRKAG1 22359576 2597767 Positive_regulation PGC PRKAG1 22500113 1223994 Positive_regulation PGC PRKAG1 22548174 1155557 Positive_regulation PGC PRKAG1 22808092 2664289 Positive_regulation PGC PRKAG1 22808092 2664302 Positive_regulation PGC PRKAG1 22829833 1068728 Positive_regulation PGC PRKAG1 22829833 1068729 Positive_regulation PGC PRKAG1 22829833 1068730 Positive_regulation PGC PRKAG1 22837722 1096659 Positive_regulation PGC PRKAG1 22837722 1096665 Positive_regulation PGC PRKAG1 22919323 3153787 Positive_regulation PGC PRKAG1 23137106 509383 Positive_regulation PGC PRKAG1 23242154 1100015 Positive_regulation PGC PRKAG1 23250358 725424 Positive_regulation PGC PRKAG1 23272147 2729769 Positive_regulation PGC PRKAG1 23434656 1101845 Positive_regulation PGC PRKAG1 23738041 2226054 Positive_regulation PGC PRKAG1 23738041 2226060 Positive_regulation PGC PRKAG1 23738041 2226068 Positive_regulation PGC PRKAG1 23755172 2801615 Positive_regulation PGC PRKAG1 23861927 2820857 Positive_regulation PGC PRKAG1 23861927 2820864 Positive_regulation PGC PRKAG1 23874150 2283634 Positive_regulation PGC PRKAG1 23874150 2283662 Positive_regulation PGC PRKAG1 23874150 2283670 Positive_regulation PGC PRKAG1 23874150 2283688 Positive_regulation PGC PRKAG1 23874150 2283724 Positive_regulation PGC PRKAG1 23874150 2283731 Positive_regulation PGC PRKAG1 24070020 1869755 Positive_regulation PGC PRKAG1 24265619 962949 Positive_regulation PGC PRKAG1 24296486 31732 Positive_regulation PGC PRKAG1 24296486 31806 Positive_regulation PGC PRKAG1 24296486 31861 Positive_regulation PGC PRKAG1 24296486 31873 Positive_regulation PGC PRKAG1 24624081 858845 Positive_regulation PGC PRKAG1 24801481 2961400 Positive_regulation PGC PRKAG1 24801481 2961401 Positive_regulation PGC PRKAG1 24801481 2961415 Positive_regulation PGC PRKAG1 24843073 2252137 Positive_regulation PGC PRKAG1 24843073 2252149 Positive_regulation PGC PRKAG1 24843073 2252161 Positive_regulation PGC PRKAG1 24843073 2252170 Positive_regulation PGC PRKAG1 24843427 1493151 Positive_regulation PGC PRKAG1 25002755 1760046 Positive_regulation PGC PRKAG1 25057490 195434 Positive_regulation PGC PRKAG1 25061561 1888289 Positive_regulation PGC PRKAG1 25152028 19611 Positive_regulation PGC PRKAG1 25152028 19612 Positive_regulation PGC PRKAG1 25166345 2301401 Positive_regulation PGC PRKAG1 25221554 914031 Positive_regulation PGC PRKAG1 25371775 2230195 Positive_regulation PGC PRKAG1 25400942 1670064 Positive_regulation PGC PRKAG1 25484869 967154 Positive_regulation PGC PRKAG1 25566462 1498481 Positive_regulation PGC PRKAG1 25625009 3163477 Positive_regulation PGC PRKAG2 18431490 2387731 Positive_regulation PGC PRKAG2 18560589 2391488 Positive_regulation PGC PRKAG2 18974883 2399621 Positive_regulation PGC PRKAG2 18974883 2399641 Positive_regulation PGC PRKAG2 18974883 2399733 Positive_regulation PGC PRKAG2 19333447 1088187 Positive_regulation PGC PRKAG2 19366864 708324 Positive_regulation PGC PRKAG2 19366864 708336 Positive_regulation PGC PRKAG2 19730740 2425823 Positive_regulation PGC PRKAG2 19934007 711940 Positive_regulation PGC PRKAG2 20157566 25972 Positive_regulation PGC PRKAG2 20190133 712979 Positive_regulation PGC PRKAG2 20338882 2052667 Positive_regulation PGC PRKAG2 20383327 2445893 Positive_regulation PGC PRKAG2 20383327 2445899 Positive_regulation PGC PRKAG2 20847946 3075190 Positive_regulation PGC PRKAG2 21040371 174499 Positive_regulation PGC PRKAG2 21431325 1644392 Positive_regulation PGC PRKAG2 21483791 2512217 Positive_regulation PGC PRKAG2 21629705 1155239 Positive_regulation PGC PRKAG2 21723506 590228 Positive_regulation PGC PRKAG2 21768291 1389993 Positive_regulation PGC PRKAG2 21887385 2549843 Positive_regulation PGC PRKAG2 22175013 1686847 Positive_regulation PGC PRKAG2 22175016 1686902 Positive_regulation PGC PRKAG2 22203837 832457 Positive_regulation PGC PRKAG2 22359576 2597768 Positive_regulation PGC PRKAG2 22500113 1223995 Positive_regulation PGC PRKAG2 22548174 1155558 Positive_regulation PGC PRKAG2 22808092 2664290 Positive_regulation PGC PRKAG2 22808092 2664303 Positive_regulation PGC PRKAG2 22829833 1068731 Positive_regulation PGC PRKAG2 22829833 1068732 Positive_regulation PGC PRKAG2 22829833 1068733 Positive_regulation PGC PRKAG2 22837722 1096660 Positive_regulation PGC PRKAG2 22837722 1096666 Positive_regulation PGC PRKAG2 22919323 3153788 Positive_regulation PGC PRKAG2 23137106 509384 Positive_regulation PGC PRKAG2 23242154 1100016 Positive_regulation PGC PRKAG2 23250358 725425 Positive_regulation PGC PRKAG2 23272147 2729770 Positive_regulation PGC PRKAG2 23434656 1101846 Positive_regulation PGC PRKAG2 23738041 2226055 Positive_regulation PGC PRKAG2 23738041 2226061 Positive_regulation PGC PRKAG2 23738041 2226069 Positive_regulation PGC PRKAG2 23755172 2801616 Positive_regulation PGC PRKAG2 23861927 2820858 Positive_regulation PGC PRKAG2 23861927 2820865 Positive_regulation PGC PRKAG2 23874150 2283635 Positive_regulation PGC PRKAG2 23874150 2283663 Positive_regulation PGC PRKAG2 23874150 2283671 Positive_regulation PGC PRKAG2 23874150 2283689 Positive_regulation PGC PRKAG2 23874150 2283725 Positive_regulation PGC PRKAG2 23874150 2283732 Positive_regulation PGC PRKAG2 24070020 1869756 Positive_regulation PGC PRKAG2 24265619 962950 Positive_regulation PGC PRKAG2 24296486 31733 Positive_regulation PGC PRKAG2 24296486 31807 Positive_regulation PGC PRKAG2 24296486 31862 Positive_regulation PGC PRKAG2 24296486 31874 Positive_regulation PGC PRKAG2 24624081 858846 Positive_regulation PGC PRKAG2 24801481 2961402 Positive_regulation PGC PRKAG2 24801481 2961403 Positive_regulation PGC PRKAG2 24801481 2961416 Positive_regulation PGC PRKAG2 24843073 2252138 Positive_regulation PGC PRKAG2 24843073 2252150 Positive_regulation PGC PRKAG2 24843073 2252162 Positive_regulation PGC PRKAG2 24843073 2252171 Positive_regulation PGC PRKAG2 24843427 1493152 Positive_regulation PGC PRKAG2 25002755 1760047 Positive_regulation PGC PRKAG2 25057490 195435 Positive_regulation PGC PRKAG2 25061561 1888290 Positive_regulation PGC PRKAG2 25152028 19613 Positive_regulation PGC PRKAG2 25152028 19614 Positive_regulation PGC PRKAG2 25166345 2301402 Positive_regulation PGC PRKAG2 25221554 914032 Positive_regulation PGC PRKAG2 25371775 2230196 Positive_regulation PGC PRKAG2 25400942 1670065 Positive_regulation PGC PRKAG2 25484869 967155 Positive_regulation PGC PRKAG2 25566462 1498482 Positive_regulation PGC PRKAG2 25625009 3163478 Positive_regulation PGC PRKAR1A 22500113 1223984 Positive_regulation PGC PRKAR1A 22500113 1224023 Positive_regulation PGC PRKAR1A 22500113 1224041 Positive_regulation PGC PRKAR1A 23093952 3076063 Positive_regulation PGC PRKAR1A 23110128 2706540 Positive_regulation PGC PRKAR1A 23554809 3076654 Positive_regulation PGC PRKAR1A 24642777 2935258 Positive_regulation PGC PRKAR1B 22500113 1223985 Positive_regulation PGC PRKAR1B 22500113 1224024 Positive_regulation PGC PRKAR1B 22500113 1224042 Positive_regulation PGC PRKAR1B 23093952 3076064 Positive_regulation PGC PRKAR1B 23110128 2706541 Positive_regulation PGC PRKAR1B 23554809 3076655 Positive_regulation PGC PRKAR1B 24642777 2935259 Positive_regulation PGC PRKAR2A 22500113 1223986 Positive_regulation PGC PRKAR2A 22500113 1224025 Positive_regulation PGC PRKAR2A 22500113 1224043 Positive_regulation PGC PRKAR2A 23093952 3076065 Positive_regulation PGC PRKAR2A 23110128 2706542 Positive_regulation PGC PRKAR2A 23554809 3076656 Positive_regulation PGC PRKAR2A 24642777 2935260 Positive_regulation PGC PRKAR2B 22500113 1223987 Positive_regulation PGC PRKAR2B 22500113 1224026 Positive_regulation PGC PRKAR2B 22500113 1224044 Positive_regulation PGC PRKAR2B 23093952 3076066 Positive_regulation PGC PRKAR2B 23110128 2706543 Positive_regulation PGC PRKAR2B 23554809 3076657 Positive_regulation PGC PRKAR2B 24642777 2935261 Positive_regulation PGC QRICH1 20410436 83603 Positive_regulation PGC QRICH1 20410436 83605 Positive_regulation PGC QRICH1 24304688 493408 Positive_regulation PGC QRICH2 20410436 83604 Positive_regulation PGC QRICH2 20410436 83606 Positive_regulation PGC QRICH2 24304688 493409 Positive_regulation PGC RB1 23895241 213829 Positive_regulation PGC RBL1 20713602 1378389 Positive_regulation PGC RBL1 20713602 1378390 Positive_regulation PGC RBL1 20713602 1378391 Positive_regulation PGC RBL1 20713602 1378402 Positive_regulation PGC RCOR1 22453831 1933616 Positive_regulation PGC RCOR1 22453831 1933634 Positive_regulation PGC RCOR3 22453831 1933620 Positive_regulation PGC RCOR3 22453831 1933638 Positive_regulation PGC RELB 24472138 1727085 Positive_regulation PGC RHOA 23728423 1929107 Positive_regulation PGC RNF19A 21040371 174493 Positive_regulation PGC RNF19A 23093952 3076046 Positive_regulation PGC RPS6KA5 21493629 1033405 Positive_regulation PGC RPS6KA5 21493629 1033406 Positive_regulation PGC RPS6KA5 21493629 1033407 Positive_regulation PGC RPS6KA5 21493629 1033414 Positive_regulation PGC RPS6KA5 21493629 1033417 Positive_regulation PGC RPTOR 25166345 2301354 Positive_regulation PGC RREB1 22453831 1933613 Positive_regulation PGC RREB1 22453831 1933631 Positive_regulation PGC S100A7 24671027 2946450 Positive_regulation PGC SETD2 21437130 731293 Positive_regulation PGC SIRT1 18031569 32512 Positive_regulation PGC SIRT1 18031569 32513 Positive_regulation PGC SIRT1 18031569 32516 Positive_regulation PGC SIRT1 19247483 2406594 Positive_regulation PGC SIRT1 19500359 2112540 Positive_regulation PGC SIRT1 19934007 711927 Positive_regulation PGC SIRT1 20157548 25879 Positive_regulation PGC SIRT1 20157566 25983 Positive_regulation PGC SIRT1 20375469 27143 Positive_regulation PGC SIRT1 20532036 2452171 Positive_regulation PGC SIRT1 20689156 27643 Positive_regulation PGC SIRT1 21076574 1710263 Positive_regulation PGC SIRT1 21483036 29429 Positive_regulation PGC SIRT1 21525818 1734950 Positive_regulation PGC SIRT1 21629705 1155256 Positive_regulation PGC SIRT1 21731503 2324966 Positive_regulation PGC SIRT1 21867551 358366 Positive_regulation PGC SIRT1 21901160 2550237 Positive_regulation PGC SIRT1 21910904 845880 Positive_regulation PGC SIRT1 22096235 2069568 Positive_regulation PGC SIRT1 22175013 1686831 Positive_regulation PGC SIRT1 22185590 2113022 Positive_regulation PGC SIRT1 22203837 832451 Positive_regulation PGC SIRT1 22203837 832460 Positive_regulation PGC SIRT1 22253880 2588273 Positive_regulation PGC SIRT1 22363287 950835 Positive_regulation PGC SIRT1 22447225 14605 Positive_regulation PGC SIRT1 22447225 14629 Positive_regulation PGC SIRT1 22548174 1155551 Positive_regulation PGC SIRT1 22548174 1155560 Positive_regulation PGC SIRT1 22622703 142904 Positive_regulation PGC SIRT1 22622703 142905 Positive_regulation PGC SIRT1 22808092 2664297 Positive_regulation PGC SIRT1 22829833 1068688 Positive_regulation PGC SIRT1 22829833 1068706 Positive_regulation PGC SIRT1 22829833 1068767 Positive_regulation PGC SIRT1 22969827 815223 Positive_regulation PGC SIRT1 23028640 2692007 Positive_regulation PGC SIRT1 23293585 866410 Positive_regulation PGC SIRT1 23354482 1101412 Positive_regulation PGC SIRT1 23755172 2801610 Positive_regulation PGC SIRT1 23776383 93713 Positive_regulation PGC SIRT1 23874150 2283665 Positive_regulation PGC SIRT1 23874150 2283739 Positive_regulation PGC SIRT1 23874150 2283741 Positive_regulation PGC SIRT1 23990359 728508 Positive_regulation PGC SIRT1 24069505 2226986 Positive_regulation PGC SIRT1 24077237 2118267 Positive_regulation PGC SIRT1 24199159 730965 Positive_regulation PGC SIRT1 24265619 962941 Positive_regulation PGC SIRT1 24367290 868358 Positive_regulation PGC SIRT1 24505445 2920899 Positive_regulation PGC SIRT1 24567900 1887681 Positive_regulation PGC SIRT1 24623376 784463 Positive_regulation PGC SIRT1 24679124 540037 Positive_regulation PGC SIRT1 24742694 2188989 Positive_regulation PGC SIRT1 24747689 2955889 Positive_regulation PGC SIRT1 24747689 2955891 Positive_regulation PGC SIRT1 24814483 590464 Positive_regulation PGC SIRT1 24990154 3144001 Positive_regulation PGC SIRT1 24990154 3144004 Positive_regulation PGC SIRT1 25032964 2360449 Positive_regulation PGC SIRT1 25032964 2360450 Positive_regulation PGC SIRT1 25057490 195418 Positive_regulation PGC SIRT1 25192192 2245336 Positive_regulation PGC SIRT1 25356430 87740 Positive_regulation PGC SIRT1 25386563 1496741 Positive_regulation PGC SIRT1 25387075 1133933 Positive_regulation PGC SIRT1 25400942 1670059 Positive_regulation PGC SIRT1 25566433 1498403 Positive_regulation PGC SIRT3 20157566 25962 Positive_regulation PGC SIRT3 20157566 25963 Positive_regulation PGC SIRT3 20157566 25984 Positive_regulation PGC SIRT3 20661474 2456763 Positive_regulation PGC SIRT3 20661474 2456767 Positive_regulation PGC SIRT3 20661474 2456773 Positive_regulation PGC SIRT3 20661474 2456774 Positive_regulation PGC SIRT3 20661474 2456775 Positive_regulation PGC SIRT3 20661474 2456777 Positive_regulation PGC SIRT3 20661474 2456778 Positive_regulation PGC SIRT3 20661474 2456779 Positive_regulation PGC SIRT3 20661474 2456789 Positive_regulation PGC SIRT3 21566744 3188823 Positive_regulation PGC SIRT3 21901160 2550241 Positive_regulation PGC SIRT3 23166782 2718948 Positive_regulation PGC SIRT3 23304112 3076116 Positive_regulation PGC SIRT3 24069505 2226973 Positive_regulation PGC SIRT3 24480485 452242 Positive_regulation PGC SIRT3 24503539 571950 Positive_regulation PGC SLC2A4 22359576 2597736 Positive_regulation PGC SLC2A4 23250358 725418 Positive_regulation PGC SLC2A4 25136584 197214 Positive_regulation PGC SLC33A1 19074984 707535 Positive_regulation PGC SMAD4 19849841 302800 Positive_regulation PGC SNAP25 23242154 1100021 Positive_regulation PGC SOD1 25162824 1129237 Positive_regulation PGC SOD2 25162824 1129238 Positive_regulation PGC SOD3 25162824 1129239 Positive_regulation PGC STK11 21124456 1986875 Positive_regulation PGC TBL1X 23304112 3076130 Positive_regulation PGC TBL1XR1 23304112 3076132 Positive_regulation PGC TCF12 18697814 2035868 Positive_regulation PGC TCF12 23242154 1099998 Positive_regulation PGC TCF12 23443131 1102666 Positive_regulation PGC TCF12 25298745 3102626 Positive_regulation PGC TCF15 18697814 2035869 Positive_regulation PGC TCF15 23242154 1099999 Positive_regulation PGC TCF15 23443131 1102667 Positive_regulation PGC TCF15 25298745 3102627 Positive_regulation PGC TCF19 18697814 2035870 Positive_regulation PGC TCF19 23242154 1100000 Positive_regulation PGC TCF19 23443131 1102668 Positive_regulation PGC TCF19 25298745 3102628 Positive_regulation PGC TCF20 18697814 2035871 Positive_regulation PGC TCF20 23242154 1100001 Positive_regulation PGC TCF20 23443131 1102669 Positive_regulation PGC TCF20 25298745 3102629 Positive_regulation PGC TCF21 18697814 2035872 Positive_regulation PGC TCF21 23242154 1100002 Positive_regulation PGC TCF21 23443131 1102670 Positive_regulation PGC TCF21 25298745 3102630 Positive_regulation PGC TCF23 18697814 2035876 Positive_regulation PGC TCF23 23242154 1100006 Positive_regulation PGC TCF23 23443131 1102674 Positive_regulation PGC TCF23 25298745 3102634 Positive_regulation PGC TCF24 18697814 2035878 Positive_regulation PGC TCF24 23242154 1100008 Positive_regulation PGC TCF24 23443131 1102676 Positive_regulation PGC TCF24 25298745 3102636 Positive_regulation PGC TCF25 18697814 2035877 Positive_regulation PGC TCF25 23242154 1100007 Positive_regulation PGC TCF25 23443131 1102675 Positive_regulation PGC TCF25 25298745 3102635 Positive_regulation PGC TCF3 18697814 2035873 Positive_regulation PGC TCF3 23242154 1100003 Positive_regulation PGC TCF3 23443131 1102671 Positive_regulation PGC TCF3 25298745 3102631 Positive_regulation PGC TCF4 18697814 2035874 Positive_regulation PGC TCF4 23242154 1100004 Positive_regulation PGC TCF4 23443131 1102672 Positive_regulation PGC TCF4 25298745 3102632 Positive_regulation PGC TCF7 18697814 2035875 Positive_regulation PGC TCF7 23242154 1100005 Positive_regulation PGC TCF7 23443131 1102673 Positive_regulation PGC TCF7 25298745 3102633 Positive_regulation PGC TDRD7 23777831 828377 Positive_regulation PGC TFAM 22848618 2669826 Positive_regulation PGC TFEB 25295245 200713 Positive_regulation PGC TFF3 24086476 2854334 Positive_regulation PGC TGFBRAP1 24286320 222129 Positive_regulation PGC TNF 22082477 682663 Positive_regulation PGC TNF 24898700 1483518 Positive_regulation PGC TNFRSF12A 23342071 2741977 Positive_regulation PGC TNFRSF12A 23342071 2741994 Positive_regulation PGC TNFSF12 23342071 2741976 Positive_regulation PGC TP53 20042072 328070 Positive_regulation PGC TP53 25061009 3203870 Positive_regulation PGC TP53 25206336 954821 Positive_regulation PGC TRAF2 23342071 2741993 Positive_regulation PGC TWIST1 23093952 3076014 Positive_regulation PGC TWIST1 23093952 3076034 Positive_regulation PGC TWIST1 23093952 3076035 Positive_regulation PGC UCP1 17389766 3071535 Positive_regulation PGC UCP1 17389766 3071542 Positive_regulation PGC UCP1 23717545 2798144 Positive_regulation PGC UCP1 24059847 290134 Positive_regulation PGC UCP1 25610428 881538 Positive_regulation PGC UGCG 23274887 725450 Positive_regulation PGC UGCG 23274887 725451 Positive_regulation PGC UGCG 23274887 725457 Positive_regulation PGC UGCG 23274887 725473 Positive_regulation PGC UGCG 23274887 725478 Positive_regulation PGC USF1 18974883 2399609 Positive_regulation PGC USF1 18974883 2399663 Positive_regulation PGC USP2 22447855 722481 Positive_regulation PGC UTRN 24447845 3163262 Positive_regulation PGC UTRN 24447845 3163267 Positive_regulation PGC VEGFA 23805408 20458 Positive_regulation PGC VEGFA 23805408 20460 Positive_regulation PGC VEGFA 23805408 20462 Positive_regulation PGC VEGFA 25007941 1993422 Positive_regulation PGC WNT1 24832654 177024 Positive_regulation PGC WNT11 24832654 177025 Positive_regulation PGC WNT16 24832654 177030 Positive_regulation PGC WNT2 24832654 177026 Positive_regulation PGC WNT3 23469192 2763032 Positive_regulation PGC WNT3 24832654 177027 Positive_regulation PGC WNT4 24832654 177028 Positive_regulation PGC WNT6 24832654 177029 Positive_regulation PGC ZMYM2 22453831 1933614 Positive_regulation PGC ZMYM2 22453831 1933632 Positive_regulation PGC ZNF217 22453831 1933615 Positive_regulation PGC ZNF217 22453831 1933633 Positive_regulation PGC ZNF746 25099937 2995777 Positive_regulation PGD IL1B 9836494 1763961 Positive_regulation PGD IL1B 9836494 1763962 Positive_regulation PGD IL1B 9836494 1764024 Positive_regulation PGD MAP2K6 22783258 902328 Positive_regulation PGF EPHB2 11914123 276476 Positive_regulation PGF EPHB2 11914123 276518 Positive_regulation PGF EPHB2 22967907 1506600 Positive_regulation PGF IL1B 9927229 1764287 Positive_regulation PGF IL1B 9927229 1764288 Positive_regulation PGF OXTR 25049471 136109 Positive_regulation PGF RCAN1 19819266 158557 Positive_regulation PGF TNF 14613529 3095435 Positive_regulation PGF TNF 14613529 3095437 Positive_regulation PGF TNF 14613529 3095445 Positive_regulation PGF TNF 14613529 3095448 Positive_regulation PGF TNF 14613533 3095482 Positive_regulation PGF TNF 14641941 3095615 Positive_regulation PGF TNF 23563496 1685197 Positive_regulation PGF TNF 24096613 1685237 Positive_regulation PGF TNF 24096613 1685238 Positive_regulation PGF TNF 24663124 2938004 Positive_regulation PGLYRP3 PGLYRP4 21949809 2556603 Positive_regulation PGLYRP4 PGLYRP3 21949809 2556604 Positive_regulation PGM1 S100B 20827422 513063 Positive_regulation PGM2 S100B 20827422 513065 Positive_regulation PGM3 S100B 20827422 513067 Positive_regulation PGM5 S100B 20827422 513069 Positive_regulation PGP EPHB2 23799854 440984 Positive_regulation PGP EPHB2 23799854 440987 Positive_regulation PGP FAS 25333257 2205552 Positive_regulation PGP FAS 25333257 2205553 Positive_regulation PGP FAS 25333257 2205560 Positive_regulation PGP FAS 25333257 2205569 Positive_regulation PGP MMP28 19450278 3109595 Positive_regulation PGP MMP7 19450278 3109610 Positive_regulation PGP TNF 20300455 1214087 Positive_regulation PGP TNF 24130926 204547 Positive_regulation PGP TNF 24498193 2918887 Positive_regulation PGP TNF 24498193 2918892 Positive_regulation PGP TNF 24830744 2970305 Positive_regulation PGP TNFSF10 20663232 1857148 Positive_regulation PGR CCND1 24575359 86189 Positive_regulation PHB MAP2K6 24096434 93481 Positive_regulation PHC1 ZFP57 20808772 2471961 Positive_regulation PHC1 ZFP57 20808772 2472016 Positive_regulation PHF21A PGC 22453831 1933603 Positive_regulation PHF21B PGC 22453831 1933605 Positive_regulation PHF5A SMN2 22110043 2070004 Positive_regulation PHIP CCND1 23118901 2712056 Positive_regulation PHKA2 EPHB2 20156366 255300 Positive_regulation PHKA2 FOLR1 22480867 829263 Positive_regulation PHKA2 FOLR1 23946717 2298768 Positive_regulation PHKA2 FOLR1 25268481 3011480 Positive_regulation PHKA2 FOLR1 25268481 3011484 Positive_regulation PHKA2 MIP 23226201 2723573 Positive_regulation PHKA2 TNF 20308428 1373808 Positive_regulation PHLDA1 EPHB2 18597688 251132 Positive_regulation PHLDA1 EPHB2 18597688 251148 Positive_regulation PHLDA1 EPHB2 22961087 724597 Positive_regulation PHLDA1 MAP2K6 18597688 251154 Positive_regulation PHLPP1 CAPN8 19039330 545846 Positive_regulation PHOSPHO1 MYH16 19862331 2429786 Positive_regulation PHOSPHO1 MYH3 19862331 2429793 Positive_regulation PHOSPHO2 MYH16 19862331 2429802 Positive_regulation PHOSPHO2 MYH3 19862331 2429809 Positive_regulation PHYH PGC 25610371 872916 Positive_regulation PHYH PGC 25610371 872924 Positive_regulation PI15 LBP 24743550 3066763 Positive_regulation PI16 LBP 24743550 3066760 Positive_regulation PI3 ANGPT1 16584574 279145 Positive_regulation PI3 CCND1 22220184 1156003 Positive_regulation PI3 CD14 10587349 1513467 Positive_regulation PI3 CD14 10587349 1513468 Positive_regulation PI3 CHI3L1 20224674 35542 Positive_regulation PI3 CHI3L1 23675241 1064704 Positive_regulation PI3 CHI3L1 24729664 1758078 Positive_regulation PI3 CTGF 19152120 1478383 Positive_regulation PI3 EPHB2 11435472 1519551 Positive_regulation PI3 EPHB2 18404483 3087818 Positive_regulation PI3 EPHB2 20544025 2452608 Positive_regulation PI3 EPHB2 21401944 304803 Positive_regulation PI3 EPHB2 23216800 2113673 Positive_regulation PI3 EPHB2 23971004 946136 Positive_regulation PI3 FOXO1 19360094 2308751 Positive_regulation PI3 FOXO1 20028942 712433 Positive_regulation PI3 GAB3 21118992 1783676 Positive_regulation PI3 GPR115 18404494 3088897 Positive_regulation PI3 GPR115 18404494 3088898 Positive_regulation PI3 GPR115 18404494 3088899 Positive_regulation PI3 GPR132 18404494 3088864 Positive_regulation PI3 GPR132 18404494 3088865 Positive_regulation PI3 GPR132 18404494 3088866 Positive_regulation PI3 GPR87 18404494 3089104 Positive_regulation PI3 GPR87 18404494 3089105 Positive_regulation PI3 GPR87 18404494 3089106 Positive_regulation PI3 IL1B 22737250 2655716 Positive_regulation PI3 LAMB3 18283320 430365 Positive_regulation PI3 LBP 24743550 3066764 Positive_regulation PI3 MAP2K6 12838322 422814 Positive_regulation PI3 MAP2K6 15067018 1307710 Positive_regulation PI3 MAP2K6 21401944 304809 Positive_regulation PI3 MAP2K6 21811445 973544 Positive_regulation PI3 MAP2K6 22537161 1865627 Positive_regulation PI3 MAP2K6 24901342 2976841 Positive_regulation PI3 MIP 19781090 1625762 Positive_regulation PI3 PTGER2 23575689 1936000 Positive_regulation PI3 TLR7 18947379 111823 Positive_regulation PI3 TNF 20308428 1373809 Positive_regulation PI3 TNF 23071583 2703027 Positive_regulation PI3 TNF 25132732 1760498 Positive_regulation PI3 TNF PMC4036665 2246876 Positive_regulation PIAS1 TNF 23343355 1231918 Positive_regulation PIAS2 TNF 23343355 1231917 Positive_regulation PIAS2 TNF 23525087 1958675 Positive_regulation PIAS3 TNF 23343355 1231915 Positive_regulation PIAS4 TNF 23343355 1231916 Positive_regulation PIEZO1 SMN2 23615451 1814184 Positive_regulation PIGR CD79A 24220295 1920129 Positive_regulation PIGR CD79A 7798315 1441638 Positive_regulation PIGR ERVK-6 20706611 1216014 Positive_regulation PIGR IL17A 24220295 1920124 Positive_regulation PIGR IL1A 24220295 1920125 Positive_regulation PIGR IL4 8655590 1452052 Positive_regulation PIGR MYD88 22491177 1918756 Positive_regulation PIGR NELFCD 22074767 1490594 Positive_regulation PIGR SLC22A3 22025622 1651682 Positive_regulation PIGR SLC22A3 22025622 1651683 Positive_regulation PIGR SMAD1 22025622 1651714 Positive_regulation PIGR SMAD2 22025622 1651715 Positive_regulation PIGR SMAD3 22025622 1651716 Positive_regulation PIGR SMAD4 22025622 1651717 Positive_regulation PIGR SMAD5 22025622 1651718 Positive_regulation PIGR SMAD6 22025622 1651719 Positive_regulation PIGR SMAD7 22025622 1651720 Positive_regulation PIGR SMAD9 22025622 1651721 Positive_regulation PIGR TLR1 21451502 1918181 Positive_regulation PIGR TLR1 21451502 1918182 Positive_regulation PIGR TLR1 21451502 1918268 Positive_regulation PIGR TLR1 21451502 1918307 Positive_regulation PIGR TLR1 21451502 1918329 Positive_regulation PIGR TLR1 22491177 1918735 Positive_regulation PIGR TLR10 21451502 1918199 Positive_regulation PIGR TLR10 21451502 1918200 Positive_regulation PIGR TLR10 21451502 1918278 Positive_regulation PIGR TLR10 21451502 1918315 Positive_regulation PIGR TLR10 21451502 1918337 Positive_regulation PIGR TLR10 22491177 1918743 Positive_regulation PIGR TLR2 21451502 1918183 Positive_regulation PIGR TLR2 21451502 1918184 Positive_regulation PIGR TLR2 21451502 1918269 Positive_regulation PIGR TLR2 21451502 1918308 Positive_regulation PIGR TLR2 21451502 1918330 Positive_regulation PIGR TLR2 22491177 1918736 Positive_regulation PIGR TLR3 21451502 1918185 Positive_regulation PIGR TLR3 21451502 1918186 Positive_regulation PIGR TLR3 21451502 1918270 Positive_regulation PIGR TLR3 21451502 1918309 Positive_regulation PIGR TLR3 21451502 1918331 Positive_regulation PIGR TLR3 22491177 1918737 Positive_regulation PIGR TLR4 21451502 1918187 Positive_regulation PIGR TLR4 21451502 1918188 Positive_regulation PIGR TLR4 21451502 1918271 Positive_regulation PIGR TLR4 21451502 1918310 Positive_regulation PIGR TLR4 21451502 1918332 Positive_regulation PIGR TLR4 22491177 1918738 Positive_regulation PIGR TLR5 21451502 1918189 Positive_regulation PIGR TLR5 21451502 1918190 Positive_regulation PIGR TLR5 21451502 1918272 Positive_regulation PIGR TLR5 21451502 1918311 Positive_regulation PIGR TLR5 21451502 1918333 Positive_regulation PIGR TLR5 22491177 1918739 Positive_regulation PIGR TLR6 21451502 1918201 Positive_regulation PIGR TLR6 21451502 1918202 Positive_regulation PIGR TLR6 21451502 1918279 Positive_regulation PIGR TLR6 21451502 1918316 Positive_regulation PIGR TLR6 21451502 1918338 Positive_regulation PIGR TLR6 22491177 1918744 Positive_regulation PIGR TLR7 21451502 1918193 Positive_regulation PIGR TLR7 21451502 1918194 Positive_regulation PIGR TLR7 21451502 1918275 Positive_regulation PIGR TLR7 21451502 1918312 Positive_regulation PIGR TLR7 21451502 1918334 Positive_regulation PIGR TLR7 22491177 1918740 Positive_regulation PIGR TLR8 21451502 1918195 Positive_regulation PIGR TLR8 21451502 1918196 Positive_regulation PIGR TLR8 21451502 1918276 Positive_regulation PIGR TLR8 21451502 1918313 Positive_regulation PIGR TLR8 21451502 1918335 Positive_regulation PIGR TLR8 22491177 1918741 Positive_regulation PIGR TLR9 21451502 1918197 Positive_regulation PIGR TLR9 21451502 1918198 Positive_regulation PIGR TLR9 21451502 1918277 Positive_regulation PIGR TLR9 21451502 1918314 Positive_regulation PIGR TLR9 21451502 1918336 Positive_regulation PIGR TLR9 22491177 1918742 Positive_regulation PIGR TNF 21451502 1918191 Positive_regulation PIGR TNF 21451502 1918192 Positive_regulation PIGR TNF 21451502 1918244 Positive_regulation PIGR TNF 21451502 1918273 Positive_regulation PIGR TNF 21451502 1918274 Positive_regulation PIGR TNF 21451502 1918352 Positive_regulation PIGR TNF 21451502 1918354 Positive_regulation PIGR TNF 21451502 1918423 Positive_regulation PIK3C3 DAPK1 22095288 547706 Positive_regulation PIK3CA ANGPT1 25371820 1690117 Positive_regulation PIK3CA AXIN2 20578217 1237708 Positive_regulation PIK3CA CCND1 24223153 2876550 Positive_regulation PIK3CA CTGF 23755163 2801570 Positive_regulation PIK3CA EPHB2 18430238 247573 Positive_regulation PIK3CA EPHB2 19305786 683355 Positive_regulation PIK3CA EPHB2 19804648 1835333 Positive_regulation PIK3CA EPHB2 19840952 513501 Positive_regulation PIK3CA EPHB2 21048967 2480326 Positive_regulation PIK3CA EPHB2 21629786 2525662 Positive_regulation PIK3CA EPHB2 21980400 2560300 Positive_regulation PIK3CA EPHB2 22649371 874961 Positive_regulation PIK3CA EPHB2 23162692 3131688 Positive_regulation PIK3CA EPHB2 23213390 168055 Positive_regulation PIK3CA EPHB2 23345981 3177042 Positive_regulation PIK3CA EPHB2 23418602 2754854 Positive_regulation PIK3CA EPHB2 23591770 3135530 Positive_regulation PIK3CA EPHB2 24018888 1112443 Positive_regulation PIK3CA EPHB2 24071646 566662 Positive_regulation PIK3CA EPHB2 24250280 2299021 Positive_regulation PIK3CA EPHB2 24669294 847612 Positive_regulation PIK3CA EPHB2 24727794 2951723 Positive_regulation PIK3CA EPHB2 25019090 1496553 Positive_regulation PIK3CA EPHB2 25019090 1496554 Positive_regulation PIK3CA EPHB2 25123138 1129028 Positive_regulation PIK3CA EPHB2 25295009 966028 Positive_regulation PIK3CA F2R 20858278 229048 Positive_regulation PIK3CA F2R 21378407 2175473 Positive_regulation PIK3CA FOXO1 20375467 27002 Positive_regulation PIK3CA GLP1R 24307763 1755528 Positive_regulation PIK3CA GLP1R 25506055 201747 Positive_regulation PIK3CA GPR115 16433909 278802 Positive_regulation PIK3CA GPR115 21307646 2223303 Positive_regulation PIK3CA GPR115 23028778 2692804 Positive_regulation PIK3CA GPR115 23203037 1099064 Positive_regulation PIK3CA GPR115 23563366 1045345 Positive_regulation PIK3CA GPR115 24064719 3186067 Positive_regulation PIK3CA GPR132 16433909 278791 Positive_regulation PIK3CA GPR132 21307646 2223292 Positive_regulation PIK3CA GPR132 23028778 2692793 Positive_regulation PIK3CA GPR132 23203037 1099053 Positive_regulation PIK3CA GPR132 23563366 1045334 Positive_regulation PIK3CA GPR132 24064719 3186056 Positive_regulation PIK3CA GPR87 16433909 278871 Positive_regulation PIK3CA GPR87 21307646 2223372 Positive_regulation PIK3CA GPR87 23028778 2692873 Positive_regulation PIK3CA GPR87 23203037 1099133 Positive_regulation PIK3CA GPR87 23563366 1045414 Positive_regulation PIK3CA GPR87 24064719 3186136 Positive_regulation PIK3CA HBEGF 22496644 3056076 Positive_regulation PIK3CA HBEGF 24379833 2120027 Positive_regulation PIK3CA ID1 22139302 1879367 Positive_regulation PIK3CA ID1 22139302 1879384 Positive_regulation PIK3CA ID1 22139302 1879391 Positive_regulation PIK3CA ID1 24970809 2193994 Positive_regulation PIK3CA INPP4B 25126743 2997996 Positive_regulation PIK3CA ITGB2 21232086 1657681 Positive_regulation PIK3CA ITGB2 23508943 906530 Positive_regulation PIK3CA LAMB3 18283320 430359 Positive_regulation PIK3CA MAP2K6 18321244 145764 Positive_regulation PIK3CA MAP2K6 22114931 469116 Positive_regulation PIK3CA MAP2K6 22140566 2576752 Positive_regulation PIK3CA MAP2K6 22594466 1639801 Positive_regulation PIK3CA MAP2K6 23272129 2729634 Positive_regulation PIK3CA MAP2K6 23300886 2737087 Positive_regulation PIK3CA MAP2K6 23977080 2838303 Positive_regulation PIK3CA MAP2K6 24036604 2184859 Positive_regulation PIK3CA MAP2K6 24041012 746134 Positive_regulation PIK3CA MAP2K6 24263101 569194 Positive_regulation PIK3CA MAP2K6 24577313 1124449 Positive_regulation PIK3CA MAP2K6 24810962 2190438 Positive_regulation PIK3CA MUC16 23694968 3135805 Positive_regulation PIK3CA NGFR 21364635 549679 Positive_regulation PIK3CA NGFR 22880054 2673818 Positive_regulation PIK3CA NGFR 22880054 2673885 Positive_regulation PIK3CA NGFR 22880054 2673972 Positive_regulation PIK3CA NGFR 22880054 2674104 Positive_regulation PIK3CA PECAM1 20723025 1692131 Positive_regulation PIK3CA PECAM1 20723025 1692133 Positive_regulation PIK3CA PLAU 23984088 1150910 Positive_regulation PIK3CA S1PR3 21304987 2502027 Positive_regulation PIK3CA SPHK1 20634980 2455678 Positive_regulation PIK3CA SPHK1 21625639 2525230 Positive_regulation PIK3CA SPHK1 21625639 2525233 Positive_regulation PIK3CA SPHK1 21625639 2525238 Positive_regulation PIK3CA SPHK1 22096344 1628240 Positive_regulation PIK3CA TLR7 21072211 2481444 Positive_regulation PIK3CA TLR7 22606294 2642923 Positive_regulation PIK3CA TLR7 22754646 3221142 Positive_regulation PIK3CA TLR7 23508732 906484 Positive_regulation PIK3CA TLR7 24191155 909617 Positive_regulation PIK3CA TLR7 24740015 2953713 Positive_regulation PIK3CA TLR7 24740015 2953816 Positive_regulation PIK3CA TM4SF19 25344917 2206213 Positive_regulation PIK3CA TM4SF19 25344917 2206214 Positive_regulation PIK3CA TNF 16504042 278993 Positive_regulation PIK3CA TNF 18335034 2384934 Positive_regulation PIK3CA TNF 20308428 1373824 Positive_regulation PIK3CA TNF 21867555 1659550 Positive_regulation PIK3CA TNF 21867555 1659606 Positive_regulation PIK3CA TNF 22243518 1898896 Positive_regulation PIK3CA TNF 22942720 1097122 Positive_regulation PIK3CA TNF 23383143 2748440 Positive_regulation PIK3CA TNF 24586980 2928654 Positive_regulation PIK3CA TNF 25114952 3156803 Positive_regulation PIK3CA TNFSF10 25003395 505007 Positive_regulation PIK3CA TSPAN1 10491398 1249691 Positive_regulation PIK3R1 ANGPT1 25371820 1690119 Positive_regulation PIK3R1 AXIN2 20578217 1237710 Positive_regulation PIK3R1 CCND1 24223153 2876552 Positive_regulation PIK3R1 CTGF 23755163 2801571 Positive_regulation PIK3R1 EPHB2 18430238 247587 Positive_regulation PIK3R1 EPHB2 19305786 683363 Positive_regulation PIK3R1 EPHB2 19804648 1835334 Positive_regulation PIK3R1 EPHB2 19840952 513503 Positive_regulation PIK3R1 EPHB2 21048967 2480327 Positive_regulation PIK3R1 EPHB2 21629786 2525663 Positive_regulation PIK3R1 EPHB2 21980400 2560301 Positive_regulation PIK3R1 EPHB2 22649371 874962 Positive_regulation PIK3R1 EPHB2 23162692 3131690 Positive_regulation PIK3R1 EPHB2 23213390 168069 Positive_regulation PIK3R1 EPHB2 23345981 3177043 Positive_regulation PIK3R1 EPHB2 23418602 2754856 Positive_regulation PIK3R1 EPHB2 23591770 3135532 Positive_regulation PIK3R1 EPHB2 24018888 1112448 Positive_regulation PIK3R1 EPHB2 24071646 566666 Positive_regulation PIK3R1 EPHB2 24250280 2299022 Positive_regulation PIK3R1 EPHB2 24669294 847614 Positive_regulation PIK3R1 EPHB2 24727794 2951724 Positive_regulation PIK3R1 EPHB2 25019090 1496581 Positive_regulation PIK3R1 EPHB2 25019090 1496582 Positive_regulation PIK3R1 EPHB2 25123138 1129029 Positive_regulation PIK3R1 EPHB2 25295009 966033 Positive_regulation PIK3R1 F2R 20858278 229049 Positive_regulation PIK3R1 F2R 21378407 2175474 Positive_regulation PIK3R1 FOXO1 20375467 27006 Positive_regulation PIK3R1 GLP1R 24307763 1755529 Positive_regulation PIK3R1 GLP1R 25506055 201748 Positive_regulation PIK3R1 GPR115 16433909 278895 Positive_regulation PIK3R1 GPR115 21307646 2223396 Positive_regulation PIK3R1 GPR115 23028778 2692897 Positive_regulation PIK3R1 GPR115 23203037 1099157 Positive_regulation PIK3R1 GPR115 23563366 1045438 Positive_regulation PIK3R1 GPR115 24064719 3186162 Positive_regulation PIK3R1 GPR132 16433909 278884 Positive_regulation PIK3R1 GPR132 21307646 2223385 Positive_regulation PIK3R1 GPR132 23028778 2692886 Positive_regulation PIK3R1 GPR132 23203037 1099146 Positive_regulation PIK3R1 GPR132 23563366 1045427 Positive_regulation PIK3R1 GPR132 24064719 3186151 Positive_regulation PIK3R1 GPR87 16433909 278964 Positive_regulation PIK3R1 GPR87 21307646 2223465 Positive_regulation PIK3R1 GPR87 23028778 2692966 Positive_regulation PIK3R1 GPR87 23203037 1099226 Positive_regulation PIK3R1 GPR87 23563366 1045507 Positive_regulation PIK3R1 GPR87 24064719 3186231 Positive_regulation PIK3R1 HBEGF 22496644 3056077 Positive_regulation PIK3R1 HBEGF 24379833 2120029 Positive_regulation PIK3R1 ID1 22139302 1879368 Positive_regulation PIK3R1 ID1 22139302 1879385 Positive_regulation PIK3R1 ID1 22139302 1879392 Positive_regulation PIK3R1 ID1 24970809 2193995 Positive_regulation PIK3R1 INPP4B 25126743 2997997 Positive_regulation PIK3R1 ITGB2 21232086 1657684 Positive_regulation PIK3R1 ITGB2 23508943 906532 Positive_regulation PIK3R1 LAMB3 18283320 430362 Positive_regulation PIK3R1 MAP2K6 18321244 145771 Positive_regulation PIK3R1 MAP2K6 22114931 469126 Positive_regulation PIK3R1 MAP2K6 22140566 2576760 Positive_regulation PIK3R1 MAP2K6 22594466 1639808 Positive_regulation PIK3R1 MAP2K6 23272129 2729641 Positive_regulation PIK3R1 MAP2K6 23300886 2737095 Positive_regulation PIK3R1 MAP2K6 23977080 2838310 Positive_regulation PIK3R1 MAP2K6 24036604 2184867 Positive_regulation PIK3R1 MAP2K6 24041012 746141 Positive_regulation PIK3R1 MAP2K6 24263101 569202 Positive_regulation PIK3R1 MAP2K6 24577313 1124456 Positive_regulation PIK3R1 MAP2K6 24810962 2190445 Positive_regulation PIK3R1 MUC16 23694968 3135807 Positive_regulation PIK3R1 NGFR 21364635 549680 Positive_regulation PIK3R1 NGFR 22880054 2673823 Positive_regulation PIK3R1 NGFR 22880054 2673889 Positive_regulation PIK3R1 NGFR 22880054 2673974 Positive_regulation PIK3R1 NGFR 22880054 2674106 Positive_regulation PIK3R1 PECAM1 20723025 1692132 Positive_regulation PIK3R1 PECAM1 20723025 1692134 Positive_regulation PIK3R1 PLAU 23984088 1150912 Positive_regulation PIK3R1 S1PR3 21304987 2502029 Positive_regulation PIK3R1 SPHK1 20634980 2455679 Positive_regulation PIK3R1 SPHK1 21625639 2525231 Positive_regulation PIK3R1 SPHK1 21625639 2525234 Positive_regulation PIK3R1 SPHK1 21625639 2525239 Positive_regulation PIK3R1 SPHK1 22096344 1628242 Positive_regulation PIK3R1 TLR7 21072211 2481454 Positive_regulation PIK3R1 TLR7 22606294 2642933 Positive_regulation PIK3R1 TLR7 22754646 3221152 Positive_regulation PIK3R1 TLR7 23508732 906494 Positive_regulation PIK3R1 TLR7 24191155 909627 Positive_regulation PIK3R1 TLR7 24740015 2953723 Positive_regulation PIK3R1 TLR7 24740015 2953826 Positive_regulation PIK3R1 TM4SF19 25344917 2206225 Positive_regulation PIK3R1 TM4SF19 25344917 2206226 Positive_regulation PIK3R1 TNF 16504042 278994 Positive_regulation PIK3R1 TNF 20308428 1373825 Positive_regulation PIK3R1 TNF 21867555 1659551 Positive_regulation PIK3R1 TNF 21867555 1659607 Positive_regulation PIK3R1 TNF 22243518 1898897 Positive_regulation PIK3R1 TNF 22942720 1097123 Positive_regulation PIK3R1 TNF 23383143 2748448 Positive_regulation PIK3R1 TNF 24586980 2928657 Positive_regulation PIK3R1 TNF 25114952 3156804 Positive_regulation PIK3R1 TNFSF10 25003395 505008 Positive_regulation PIK3R1 TSPAN1 10491398 1249713 Positive_regulation PIM1 STAT4 23209281 1205776 Positive_regulation PIM2 STAT4 23209281 1205777 Positive_regulation PIM3 STAT4 23209281 1205775 Positive_regulation PIN1 DAPK1 24853415 575973 Positive_regulation PIN1 DAPK1 24853415 575978 Positive_regulation PINK1 SARM1 23885119 1817375 Positive_regulation PINK1 SARM1 23885119 1817383 Positive_regulation PINK1 SARM1 23885119 1817384 Positive_regulation PINK1 SARM1 23885119 1817385 Positive_regulation PINK1 TNF 22523581 2620388 Positive_regulation PINK1 TNF 22925731 357272 Positive_regulation PIP EPHB2 22817771 471860 Positive_regulation PIP EPHB2 22817771 471861 Positive_regulation PIP EPHB2 22817771 472008 Positive_regulation PIP MAP2K6 22817771 472022 Positive_regulation PKD1 DAPK1 22095288 547651 Positive_regulation PKD1 DAPK1 22095288 547652 Positive_regulation PKD1 DAPK1 22095288 547653 Positive_regulation PKD1 DAPK1 22095288 547683 Positive_regulation PKD1 FHL1 24219103 151914 Positive_regulation PKD1 FHL1 24219103 151915 Positive_regulation PKD1 FHL1 24219103 151916 Positive_regulation PKD1 TLR7 22928050 2681664 Positive_regulation PKD1 TLR7 22928050 2681857 Positive_regulation PKD1 TLR7 22928050 2681871 Positive_regulation PKD2 DAPK1 22095288 547659 Positive_regulation PKD2 DAPK1 22095288 547660 Positive_regulation PKD2 DAPK1 22095288 547686 Positive_regulation PKD2 FHL1 24219103 151920 Positive_regulation PKD2 FHL1 24219103 151921 Positive_regulation PKD2 FHL1 24219103 151922 Positive_regulation PKD3 DAPK1 22095288 547665 Positive_regulation PKD3 DAPK1 22095288 547666 Positive_regulation PKD3 DAPK1 22095288 547689 Positive_regulation PKD3 FHL1 24219103 151926 Positive_regulation PKD3 FHL1 24219103 151927 Positive_regulation PKD3 FHL1 24219103 151928 Positive_regulation PKM DAPK1 23961261 1243181 Positive_regulation PKM EGLN3 21709315 2176242 Positive_regulation PKM EPHB2 23178880 1928771 Positive_regulation PKM EPHB2 23178880 1928772 Positive_regulation PKM EPHB2 23178880 1928811 Positive_regulation PKM EPHB2 23178880 1928822 Positive_regulation PKM EPHB2 25019241 1943129 Positive_regulation PKM FOLR1 22140559 2576659 Positive_regulation PKM FOLR1 22922757 1931680 Positive_regulation PKM FOLR1 25214764 743227 Positive_regulation PKN1 ARSA 24184502 154238 Positive_regulation PKN1 TNF 19298660 352670 Positive_regulation PKN1 TNF 19298660 352671 Positive_regulation PLA2G10 TGM2 20052409 2436665 Positive_regulation PLA2G10 TGM2 20052409 2436666 Positive_regulation PLA2G10 TGM2 20052409 2436667 Positive_regulation PLA2G10 TGM2 20052409 2436668 Positive_regulation PLA2G10 TGM2 20052409 2436669 Positive_regulation PLA2G12B PGC 21673902 1090926 Positive_regulation PLA2G15 ALOX5 22645425 3153390 Positive_regulation PLA2G15 ARSA 23843037 506270 Positive_regulation PLA2G1B EPHB2 24744506 1758212 Positive_regulation PLA2G1B FAS 23056665 2225068 Positive_regulation PLA2G1B FAS 9064324 1600229 Positive_regulation PLA2G1B HRH1 18667087 1897072 Positive_regulation PLA2G1B IL1B 25436109 1161797 Positive_regulation PLA2G1B OXTR 20626426 653834 Positive_regulation PLA2G1B TNF 10231001 1049488 Positive_regulation PLA2G1B TNF 14613529 3095447 Positive_regulation PLA2G1B TNF 1658188 1539856 Positive_regulation PLA2G1B TNF 1658188 1539857 Positive_regulation PLA2G1B TNF 1658188 1539859 Positive_regulation PLA2G1B TNF 18475466 1743840 Positive_regulation PLA2G1B TNF 18475466 1743841 Positive_regulation PLA2G1B TNF 19765281 117119 Positive_regulation PLA2G1B TNF 2125560 794259 Positive_regulation PLA2G1B TNF 2205055 3228966 Positive_regulation PLA2G1B TNF 2205055 3228993 Positive_regulation PLA2G1B TNF 22899950 814895 Positive_regulation PLA2G1B TNF 25426024 872207 Positive_regulation PLA2G1B TNF 8027185 1444181 Positive_regulation PLA2G1B TNF 8381656 444811 Positive_regulation PLA2G1B TNF 8760826 1598975 Positive_regulation PLA2G1B TNF 8760826 1598976 Positive_regulation PLA2G1B TNF 8760826 1598985 Positive_regulation PLA2G1B TNF 8760826 1598986 Positive_regulation PLA2G2A IL1A 11577997 1737906 Positive_regulation PLA2G2A TNF 11577997 1737905 Positive_regulation PLA2G4A EPHB2 19409102 1897181 Positive_regulation PLA2G4A EPHB2 19409102 1897191 Positive_regulation PLA2G4A EPHB2 21152208 22740 Positive_regulation PLA2G4A EPHB2 22911431 3058940 Positive_regulation PLA2G4A EPHB2 23675174 1064560 Positive_regulation PLA2G4A EPHB2 24721622 1679092 Positive_regulation PLA2G4A EPHB2 24721622 1679093 Positive_regulation PLA2G4A EPHB2 24721622 1679247 Positive_regulation PLA2G4A EPHB2 24721622 1679298 Positive_regulation PLA2G4A IL1B 18475724 1745699 Positive_regulation PLA2G4A LPCAT1 22296727 1899027 Positive_regulation PLA2G4A MAP2K6 16048647 3105381 Positive_regulation PLA2G4A OXTR 22190926 1072873 Positive_regulation PLA2G4A TNF 18475532 1744242 Positive_regulation PLA2G4A TNF 18638380 1722734 Positive_regulation PLA2G4A TNF 19847291 2429189 Positive_regulation PLA2G4A TNF 22832605 3189142 Positive_regulation PLA2G4A TNF 24069158 2851345 Positive_regulation PLA2G4A TNF 24069158 2851346 Positive_regulation PLA2G4A TNF 24069158 2851347 Positive_regulation PLA2G4A TNF 24069158 2851348 Positive_regulation PLA2G4A TNF 24069158 2851349 Positive_regulation PLA2G4A TNF 24069158 2851350 Positive_regulation PLA2G4A TNF 24069158 2851351 Positive_regulation PLA2G4A TNF 24069158 2851352 Positive_regulation PLA2G4A TNF 24069158 2851428 Positive_regulation PLA2G4A TNF 24069158 2851429 Positive_regulation PLA2G4A TNF 24069158 2851430 Positive_regulation PLA2G4A TNF 24069158 2851431 Positive_regulation PLA2G4A TNF 24069158 2851432 Positive_regulation PLA2G4A TNF 24069158 2851433 Positive_regulation PLA2G4A TNF 24069158 2851434 Positive_regulation PLA2G4A TNF 24069158 2851435 Positive_regulation PLA2G4A TNF 24069158 2851493 Positive_regulation PLA2G4A TNF 24069158 2851494 Positive_regulation PLA2G4A TNF 24069158 2851520 Positive_regulation PLA2G4A TNF 24069158 2851521 Positive_regulation PLA2G4A TNF 24069158 2851522 Positive_regulation PLA2G4A TNF 24069158 2851523 Positive_regulation PLA2G4A TNF 24069158 2851524 Positive_regulation PLA2G4A TNF 24069158 2851525 Positive_regulation PLA2G4A TNF 24069158 2851563 Positive_regulation PLA2G4A TNF 24069158 2851564 Positive_regulation PLA2G4A TNF 24069158 2851565 Positive_regulation PLA2G4A TNF 24069158 2851566 Positive_regulation PLA2G4A TNF 24069158 2851606 Positive_regulation PLA2G4A TNF 24069158 2851607 Positive_regulation PLA2G4A TNF 24069158 2851608 Positive_regulation PLA2G4A TNF 24069158 2851609 Positive_regulation PLA2G4A TNF 24069158 2851610 Positive_regulation PLA2G4A TNF 24069158 2851629 Positive_regulation PLA2G4A TNF 24069158 2851630 Positive_regulation PLA2G4A TNF 24069158 2851631 Positive_regulation PLA2G4A TNF 24069158 2851632 Positive_regulation PLA2G4A TNF 24069158 2851633 Positive_regulation PLA2G4A TNF 24069158 2851634 Positive_regulation PLA2G4A TNF 24069158 2851644 Positive_regulation PLA2G4A TNF 24069158 2851645 Positive_regulation PLA2G4A TNF 24069158 2851646 Positive_regulation PLA2G4A TNF 24069158 2851647 Positive_regulation PLA2G4A TNF 24069158 2851648 Positive_regulation PLA2G4A TNF 24069158 2851649 Positive_regulation PLA2G4A TNF 24069158 2851651 Positive_regulation PLA2G4A TNF 24069158 2851652 Positive_regulation PLA2G4A TNF 24069158 2851654 Positive_regulation PLA2G4A TNF 24069158 2851669 Positive_regulation PLA2G4A TNF 24069158 2851670 Positive_regulation PLA2G4A TNF 24069158 2851697 Positive_regulation PLA2G4A TNF 24069158 2851754 Positive_regulation PLA2G4A TNF 24069158 2851755 Positive_regulation PLA2G4A TNF 24349530 2898418 Positive_regulation PLA2G4A TNF 24349530 2898442 Positive_regulation PLA2G4A TNF 24349530 2898447 Positive_regulation PLA2G4A TNF 24349530 2898448 Positive_regulation PLA2G4A TNF 24616552 1757567 Positive_regulation PLA2G4A TNF 24616552 1757568 Positive_regulation PLA2G4A TNF 24616552 1757570 Positive_regulation PLA2G4A TNF 24616552 1757578 Positive_regulation PLA2G4A TNF 24616552 1757579 Positive_regulation PLA2G4A TNF 24616552 1757584 Positive_regulation PLA2G4A TNF 24616552 1757585 Positive_regulation PLA2G4A TNF 24616552 1757586 Positive_regulation PLA2G4A TNF 24616552 1757587 Positive_regulation PLA2G4A TNF 24616552 1757588 Positive_regulation PLA2G4A TNF 24616552 1757589 Positive_regulation PLA2G4A TNF 24616552 1757590 Positive_regulation PLA2G4A TNF 24616552 1757591 Positive_regulation PLA2G4A TNF 24616552 1757593 Positive_regulation PLA2G4A TNF 24616552 1757594 Positive_regulation PLA2G4A TNF 24616552 1757595 Positive_regulation PLA2G4A TNF 24616552 1757596 Positive_regulation PLA2G4A TNF 24776599 514448 Positive_regulation PLA2G4A TNF 9400742 797597 Positive_regulation PLAA IL1B 10780577 3228195 Positive_regulation PLAA TNF 2258694 1568152 Positive_regulation PLAA TNF 2499653 1577006 Positive_regulation PLAC8 PGC 25566433 1498400 Positive_regulation PLAGL1 GATM 23145134 2716180 Positive_regulation PLAGL1 STC1 23145134 2716179 Positive_regulation PLAT AKT1 23936774 182569 Positive_regulation PLAT AKT2 23936774 182570 Positive_regulation PLAT AKT3 23936774 182571 Positive_regulation PLAT ANXA2 19724273 432698 Positive_regulation PLAT ANXA2 25407528 1134467 Positive_regulation PLAT BDNF 22034132 735039 Positive_regulation PLAT BDNF 22144945 928716 Positive_regulation PLAT C14orf169 15559369 630334 Positive_regulation PLAT CCL2 22425561 1881377 Positive_regulation PLAT CRH 18818748 2396846 Positive_regulation PLAT DLG4 23866919 1895817 Positive_regulation PLAT DPP4 25140306 197513 Positive_regulation PLAT EGF 17261179 3096406 Positive_regulation PLAT ERVK-6 23878812 182435 Positive_regulation PLAT ERVK-6 23936774 182549 Positive_regulation PLAT FGF2 25426379 2255039 Positive_regulation PLAT HCLS1 17576803 1341606 Positive_regulation PLAT HRAS 11437413 419195 Positive_regulation PLAT HRAS 11437413 419211 Positive_regulation PLAT HRAS 11437413 419212 Positive_regulation PLAT IL1A 17521427 370523 Positive_regulation PLAT IL1A 24156000 1713096 Positive_regulation PLAT IL6 24312667 2890532 Positive_regulation PLAT KRAS 11437413 419196 Positive_regulation PLAT KRAS 11437413 419213 Positive_regulation PLAT KRAS 11437413 419214 Positive_regulation PLAT LEP 17521427 370524 Positive_regulation PLAT LPA 1828468 1349434 Positive_regulation PLAT LRP1 23866919 1895801 Positive_regulation PLAT LRP1 25514242 1135686 Positive_regulation PLAT MAP6 25364620 1668537 Positive_regulation PLAT MAPK3 21799677 812908 Positive_regulation PLAT MMP1 16078993 383018 Positive_regulation PLAT MMP1 24465147 842040 Positive_regulation PLAT MMP10 16078993 383019 Positive_regulation PLAT MMP10 24465147 842041 Positive_regulation PLAT MMP11 16078993 383020 Positive_regulation PLAT MMP11 24465147 842042 Positive_regulation PLAT MMP12 16078993 383021 Positive_regulation PLAT MMP12 24465147 842043 Positive_regulation PLAT MMP13 16078993 383022 Positive_regulation PLAT MMP13 23977299 2839912 Positive_regulation PLAT MMP13 23977299 2839937 Positive_regulation PLAT MMP13 24465147 842044 Positive_regulation PLAT MMP14 16078993 383023 Positive_regulation PLAT MMP14 24465147 842045 Positive_regulation PLAT MMP15 16078993 383024 Positive_regulation PLAT MMP15 24465147 842046 Positive_regulation PLAT MMP16 16078993 383025 Positive_regulation PLAT MMP16 24465147 842047 Positive_regulation PLAT MMP17 16078993 383026 Positive_regulation PLAT MMP17 24465147 842048 Positive_regulation PLAT MMP19 16078993 383027 Positive_regulation PLAT MMP19 24465147 842049 Positive_regulation PLAT MMP2 16078993 383028 Positive_regulation PLAT MMP2 23977299 2839960 Positive_regulation PLAT MMP2 24465147 842050 Positive_regulation PLAT MMP20 16078993 383029 Positive_regulation PLAT MMP20 24465147 842051 Positive_regulation PLAT MMP21 16078993 383016 Positive_regulation PLAT MMP21 24465147 842038 Positive_regulation PLAT MMP24 16078993 383030 Positive_regulation PLAT MMP24 24465147 842052 Positive_regulation PLAT MMP25 16078993 383013 Positive_regulation PLAT MMP25 24465147 842035 Positive_regulation PLAT MMP26 16078993 383014 Positive_regulation PLAT MMP26 24465147 842036 Positive_regulation PLAT MMP27 16078993 383015 Positive_regulation PLAT MMP27 24465147 842037 Positive_regulation PLAT MMP28 16078993 383017 Positive_regulation PLAT MMP28 24465147 842039 Positive_regulation PLAT MMP3 16078993 383031 Positive_regulation PLAT MMP3 23565108 935272 Positive_regulation PLAT MMP3 23565108 935335 Positive_regulation PLAT MMP3 24465147 842053 Positive_regulation PLAT MMP7 16078993 383032 Positive_regulation PLAT MMP7 24465147 842054 Positive_regulation PLAT MMP8 16078993 383033 Positive_regulation PLAT MMP8 24465147 842055 Positive_regulation PLAT MMP9 16078993 383034 Positive_regulation PLAT MMP9 20396502 1491969 Positive_regulation PLAT MMP9 23977299 2839913 Positive_regulation PLAT MMP9 23977299 2839961 Positive_regulation PLAT MMP9 24465147 842056 Positive_regulation PLAT MMP9 24885160 1668111 Positive_regulation PLAT MMP9 25407528 1134468 Positive_regulation PLAT MSC 20140248 2440220 Positive_regulation PLAT MSC 23549381 1488970 Positive_regulation PLAT MYLIP 24911610 2978873 Positive_regulation PLAT NOS2 24235858 1614624 Positive_regulation PLAT NR3C1 24126929 1901335 Positive_regulation PLAT NRAS 11437413 419197 Positive_regulation PLAT NRAS 11437413 419215 Positive_regulation PLAT NRAS 11437413 419216 Positive_regulation PLAT NTF3 17576803 1341617 Positive_regulation PLAT NTF4 17576803 1341618 Positive_regulation PLAT NTF4 22144945 928718 Positive_regulation PLAT P2RY1 18404494 3089110 Positive_regulation PLAT P2RY1 24303097 2251314 Positive_regulation PLAT PAICS 19789215 811511 Positive_regulation PLAT PDGFC 19352490 2412260 Positive_regulation PLAT PLAU 1918136 1363666 Positive_regulation PLAT PLG 16524486 249155 Positive_regulation PLAT PLG 16524486 249157 Positive_regulation PLAT PLG 16968541 3177984 Positive_regulation PLAT PLG 20514206 683568 Positive_regulation PLAT PLG 20717705 494116 Positive_regulation PLAT PLG 2104856 1382730 Positive_regulation PLAT PLG 22870270 2672130 Positive_regulation PLAT PLG 23047269 3125917 Positive_regulation PLAT PLG 23226724 842791 Positive_regulation PLAT PLG 23360524 388406 Positive_regulation PLAT PLG 23565108 935275 Positive_regulation PLAT PLG 23919120 141967 Positive_regulation PLAT PLG 24383758 157142 Positive_regulation PLAT PLG 24557578 1123943 Positive_regulation PLAT PLG 24647546 2936282 Positive_regulation PLAT PLG 2509486 1422848 Positive_regulation PLAT PLG 25147500 870742 Positive_regulation PLAT PLG 3031083 1425165 Positive_regulation PLAT PLG 8394731 444892 Positive_regulation PLAT PLG 9635833 447090 Positive_regulation PLAT RAD1 18472950 1743296 Positive_regulation PLAT RAD17 18472950 1743297 Positive_regulation PLAT RAD18 18472950 1743295 Positive_regulation PLAT RAD21 18472950 1743298 Positive_regulation PLAT RAD50 18472950 1743299 Positive_regulation PLAT RAD51 18472950 1743300 Positive_regulation PLAT RAD52 18472950 1743301 Positive_regulation PLAT RARA 11437413 419198 Positive_regulation PLAT RNF19A 21799677 812907 Positive_regulation PLAT RTN4R 25152758 826756 Positive_regulation PLAT S100A6 19724273 432697 Positive_regulation PLAT SDS 3121634 1425832 Positive_regulation PLAT SERPINB2 16262900 3105750 Positive_regulation PLAT SERPINB2 23878812 182437 Positive_regulation PLAT SERPINB2 24999729 2986616 Positive_regulation PLAT SERPINE1 14690546 507351 Positive_regulation PLAT SERPINE1 21241489 659807 Positive_regulation PLAT SERPINE1 21785728 1155316 Positive_regulation PLAT SERPINE1 23118508 1225457 Positive_regulation PLAT SERPINE1 23251286 842941 Positive_regulation PLAT SERPINE1 23878812 182436 Positive_regulation PLAT SERPINE1 23977299 2839914 Positive_regulation PLAT SERPINE1 24009867 204145 Positive_regulation PLAT SERPINE1 24235858 1614614 Positive_regulation PLAT SERPINE1 24564184 290262 Positive_regulation PLAT SERPINE1 24999729 2986615 Positive_regulation PLAT SERPINE1 25374584 2007210 Positive_regulation PLAT SERPINI1 23658802 2790289 Positive_regulation PLAT SERPINI1 24608243 2932699 Positive_regulation PLAT SERPINI1 24608243 2932702 Positive_regulation PLAT SHH 23549381 1488968 Positive_regulation PLAT SHH 23549381 1488969 Positive_regulation PLAT SHH 23549381 1488971 Positive_regulation PLAT SIGLEC7 17576803 1341616 Positive_regulation PLAT SORT1 22144945 928717 Positive_regulation PLAT SRC 24904407 859158 Positive_regulation PLAT SRGN 21880179 623905 Positive_regulation PLAT TIMP1 25374584 2007209 Positive_regulation PLAT TNF 24156000 1713095 Positive_regulation PLAT TNF 8826848 445615 Positive_regulation PLAT TNF 8826848 445620 Positive_regulation PLAT TNF 8826848 445651 Positive_regulation PLAT TNFRSF1B 17576803 1341596 Positive_regulation PLAT TNFRSF1B 17576803 1341605 Positive_regulation PLAT TNFRSF1B 17576803 1341626 Positive_regulation PLAT TNFRSF1B 19225537 1719194 Positive_regulation PLAT UTP15 21519856 3090644 Positive_regulation PLAT UTP18 21519856 3090642 Positive_regulation PLAT UTP20 21519856 3090640 Positive_regulation PLAT UTP23 21519856 3090645 Positive_regulation PLAT UTP3 21519856 3090643 Positive_regulation PLAT UTP6 21519856 3090641 Positive_regulation PLAT VEGFA 18182986 429801 Positive_regulation PLAT VWF 9314543 1464268 Positive_regulation PLAU ABCC6 22131991 1673227 Positive_regulation PLAU AHSA1 19497102 1503742 Positive_regulation PLAU AKT1 21813027 260771 Positive_regulation PLAU AKT1 23661031 735560 Positive_regulation PLAU AKT1 24629239 1873150 Positive_regulation PLAU AKT2 21813027 260772 Positive_regulation PLAU AKT2 23661031 735561 Positive_regulation PLAU AKT2 24629239 1873151 Positive_regulation PLAU AKT3 21813027 260773 Positive_regulation PLAU AKT3 23661031 735562 Positive_regulation PLAU AKT3 24629239 1873152 Positive_regulation PLAU AREG 23844004 2818953 Positive_regulation PLAU AREG 23844004 2818957 Positive_regulation PLAU ARG1 17145954 1543552 Positive_regulation PLAU ARG2 17145954 1543553 Positive_regulation PLAU BRMS1 24879377 2975656 Positive_regulation PLAU BRMS1L 22076152 2570311 Positive_regulation PLAU BSG 22443116 264366 Positive_regulation PLAU BSG 22443116 264367 Positive_regulation PLAU BSG 22443116 264368 Positive_regulation PLAU BSG 22443116 264369 Positive_regulation PLAU BSG 22443116 264379 Positive_regulation PLAU BSG 25268615 1131405 Positive_regulation PLAU CD44 17327908 2374700 Positive_regulation PLAU CD44 21124918 2484605 Positive_regulation PLAU CD44 22621373 471541 Positive_regulation PLAU CD44 22621373 471542 Positive_regulation PLAU CD44 22621373 471548 Positive_regulation PLAU CD44 22621373 471549 Positive_regulation PLAU CD44 23349823 2743430 Positive_regulation PLAU CD44 PMC2756345 496104 Positive_regulation PLAU CDC42 12952933 1296525 Positive_regulation PLAU CDC42 20067638 255081 Positive_regulation PLAU CDC42 20067638 255082 Positive_regulation PLAU CDC42 20067638 255113 Positive_regulation PLAU CDC42 20067638 255152 Positive_regulation PLAU CDC42 20067638 255163 Positive_regulation PLAU CDC42 20067638 255170 Positive_regulation PLAU CDKN1A 21592330 411497 Positive_regulation PLAU CEBPA 18445634 2034379 Positive_regulation PLAU CRK 19808845 811565 Positive_regulation PLAU CSF1 10408691 414760 Positive_regulation PLAU CSF2 10408691 414737 Positive_regulation PLAU CSF2 10408691 414761 Positive_regulation PLAU CSF3 10408691 414738 Positive_regulation PLAU CSRP1 20425246 665320 Positive_regulation PLAU CTSB 10732768 416643 Positive_regulation PLAU CTSB 22093547 469032 Positive_regulation PLAU CTSB 22093547 469043 Positive_regulation PLAU CTSB 7547226 443893 Positive_regulation PLAU CTSB 7547226 443894 Positive_regulation PLAU CTSB 8382511 444878 Positive_regulation PLAU CTSB 8382511 444879 Positive_regulation PLAU CTSL 8382511 444880 Positive_regulation PLAU CXCL12 23098564 1231474 Positive_regulation PLAU CXCR4 23098564 1231434 Positive_regulation PLAU ECM1 19820721 8269 Positive_regulation PLAU ECM1 25295247 200732 Positive_regulation PLAU ECM2 19820721 8270 Positive_regulation PLAU ECM2 25295247 200733 Positive_regulation PLAU EGF 17576449 686243 Positive_regulation PLAU EGF 9744504 447914 Positive_regulation PLAU EGFR 12556241 1843388 Positive_regulation PLAU EGFR 19483730 2125489 Positive_regulation PLAU EGFR 24340014 2894550 Positive_regulation PLAU EGFR 9635833 447103 Positive_regulation PLAU ELANE 8382511 444872 Positive_regulation PLAU ELANE 8382511 444873 Positive_regulation PLAU EPHB2 11266465 1269102 Positive_regulation PLAU EPHB2 11266465 1269103 Positive_regulation PLAU EPHB2 11266465 1269113 Positive_regulation PLAU EPHB2 11266465 1269128 Positive_regulation PLAU EPHB2 12865932 422958 Positive_regulation PLAU EPHB2 12865932 422959 Positive_regulation PLAU EPHB2 19497102 1503743 Positive_regulation PLAU EPHB2 19497102 1503760 Positive_regulation PLAU EPHB2 19497102 1503769 Positive_regulation PLAU EPHB2 21798065 1505385 Positive_regulation PLAU EPHB2 21798065 1505391 Positive_regulation PLAU EPHB2 22986534 2148783 Positive_regulation PLAU ERBB2 24709902 617319 Positive_regulation PLAU ERVK-6 23878812 182438 Positive_regulation PLAU ERVK-6 23936774 182550 Positive_regulation PLAU ETS1 12971829 1843672 Positive_regulation PLAU ETS1 12971829 1843680 Positive_regulation PLAU ETS1 22986534 2148775 Positive_regulation PLAU ETS1 25079072 2993753 Positive_regulation PLAU ETS2 15236655 3095827 Positive_regulation PLAU ETS2 9743289 447871 Positive_regulation PLAU F2RL1 21853097 2543233 Positive_regulation PLAU FGF1 1645739 1327489 Positive_regulation PLAU FGF1 19808845 811516 Positive_regulation PLAU FGF1 21799677 812913 Positive_regulation PLAU FGF10 1645739 1327490 Positive_regulation PLAU FGF10 19808845 811517 Positive_regulation PLAU FGF10 21799677 812914 Positive_regulation PLAU FGF11 1645739 1327491 Positive_regulation PLAU FGF11 19808845 811518 Positive_regulation PLAU FGF11 21799677 812915 Positive_regulation PLAU FGF12 1645739 1327492 Positive_regulation PLAU FGF12 19808845 811519 Positive_regulation PLAU FGF12 21799677 812916 Positive_regulation PLAU FGF13 1645739 1327493 Positive_regulation PLAU FGF13 19808845 811520 Positive_regulation PLAU FGF13 21799677 812917 Positive_regulation PLAU FGF14 1645739 1327494 Positive_regulation PLAU FGF14 19808845 811521 Positive_regulation PLAU FGF14 21799677 812918 Positive_regulation PLAU FGF16 1645739 1327495 Positive_regulation PLAU FGF16 19808845 811522 Positive_regulation PLAU FGF16 21799677 812919 Positive_regulation PLAU FGF17 1645739 1327496 Positive_regulation PLAU FGF17 19808845 811523 Positive_regulation PLAU FGF17 21799677 812920 Positive_regulation PLAU FGF18 1645739 1327497 Positive_regulation PLAU FGF18 19808845 811524 Positive_regulation PLAU FGF18 21799677 812921 Positive_regulation PLAU FGF19 1645739 1327498 Positive_regulation PLAU FGF19 19808845 811525 Positive_regulation PLAU FGF19 21799677 812922 Positive_regulation PLAU FGF2 10389972 414424 Positive_regulation PLAU FGF2 10864205 417151 Positive_regulation PLAU FGF2 1645739 1327499 Positive_regulation PLAU FGF2 1645739 1327513 Positive_regulation PLAU FGF2 19808845 811526 Positive_regulation PLAU FGF2 19808845 811564 Positive_regulation PLAU FGF2 20414463 1672164 Positive_regulation PLAU FGF2 21151668 812307 Positive_regulation PLAU FGF2 21799677 812923 Positive_regulation PLAU FGF2 24944688 2168646 Positive_regulation PLAU FGF2 25236925 216480 Positive_regulation PLAU FGF2 7536021 443851 Positive_regulation PLAU FGF2 9314544 1464270 Positive_regulation PLAU FGF2 9314544 1464271 Positive_regulation PLAU FGF2 9314544 1464272 Positive_regulation PLAU FGF20 1645739 1327500 Positive_regulation PLAU FGF20 19808845 811527 Positive_regulation PLAU FGF20 21799677 812924 Positive_regulation PLAU FGF21 1645739 1327501 Positive_regulation PLAU FGF21 19808845 811528 Positive_regulation PLAU FGF21 21799677 812925 Positive_regulation PLAU FGF22 1645739 1327502 Positive_regulation PLAU FGF22 19808845 811529 Positive_regulation PLAU FGF22 21799677 812926 Positive_regulation PLAU FGF23 1645739 1327503 Positive_regulation PLAU FGF23 19808845 811530 Positive_regulation PLAU FGF23 21799677 812927 Positive_regulation PLAU FGF3 1645739 1327504 Positive_regulation PLAU FGF3 19808845 811531 Positive_regulation PLAU FGF3 21799677 812928 Positive_regulation PLAU FGF4 1645739 1327505 Positive_regulation PLAU FGF4 19808845 811532 Positive_regulation PLAU FGF4 21799677 812929 Positive_regulation PLAU FGF5 1645739 1327506 Positive_regulation PLAU FGF5 19808845 811533 Positive_regulation PLAU FGF5 21799677 812930 Positive_regulation PLAU FGF6 1645739 1327507 Positive_regulation PLAU FGF6 19808845 811534 Positive_regulation PLAU FGF6 21799677 812931 Positive_regulation PLAU FGF7 1645739 1327508 Positive_regulation PLAU FGF7 19808845 811535 Positive_regulation PLAU FGF7 21799677 812932 Positive_regulation PLAU FGF7 24151975 1481814 Positive_regulation PLAU FGF8 1645739 1327509 Positive_regulation PLAU FGF8 19808845 811536 Positive_regulation PLAU FGF8 21799677 812933 Positive_regulation PLAU FGF9 1645739 1327510 Positive_regulation PLAU FGF9 19808845 811537 Positive_regulation PLAU FGF9 21799677 812934 Positive_regulation PLAU FOSL1 25200076 2104642 Positive_regulation PLAU FOSL1 25200076 2104643 Positive_regulation PLAU FOXM1 20154714 9469 Positive_regulation PLAU FOXM1 20154714 9471 Positive_regulation PLAU GAST 23853591 3062998 Positive_regulation PLAU GATA4 23125522 1225547 Positive_regulation PLAU GIF 22986534 2148781 Positive_regulation PLAU GSN 22927998 2681285 Positive_regulation PLAU GSN 22927998 2681290 Positive_regulation PLAU GSN 22927998 2681297 Positive_regulation PLAU GSN 22927998 2681298 Positive_regulation PLAU HGF 10424744 415034 Positive_regulation PLAU HGF 10468286 415067 Positive_regulation PLAU HGF 10496342 415320 Positive_regulation PLAU HGF 11259105 418479 Positive_regulation PLAU HGF 16646560 1711374 Positive_regulation PLAU HGF 16646560 1711388 Positive_regulation PLAU HGF 16646560 1711389 Positive_regulation PLAU HGF 19497102 1503744 Positive_regulation PLAU HGF 19497102 1503745 Positive_regulation PLAU HGF 19497102 1503746 Positive_regulation PLAU HGF 19497102 1503747 Positive_regulation PLAU HGF 19497102 1503761 Positive_regulation PLAU HGF 19497102 1503770 Positive_regulation PLAU HGF 19497102 1503771 Positive_regulation PLAU HGF 19497102 1503772 Positive_regulation PLAU HGF 19497102 1503780 Positive_regulation PLAU HGF 20551596 3078659 Positive_regulation PLAU HGF 24772104 880540 Positive_regulation PLAU HGF 24959301 1240509 Positive_regulation PLAU HGF 7528222 1436405 Positive_regulation PLAU HGF 7559778 1437225 Positive_regulation PLAU HGF 7806559 1441817 Positive_regulation PLAU HGF 8163548 1445338 Positive_regulation PLAU HGF 8522613 1449693 Positive_regulation PLAU HLA-G 24098421 2856297 Positive_regulation PLAU HLA-G 24098421 2856307 Positive_regulation PLAU HLA-G 24098421 2856308 Positive_regulation PLAU HOXD3 12741393 1292587 Positive_regulation PLAU HOXD3 19825192 254321 Positive_regulation PLAU HPSE 23908791 3092576 Positive_regulation PLAU HRAS 11437413 419199 Positive_regulation PLAU HRAS 20067638 255177 Positive_regulation PLAU HSP90AA1 19715605 283396 Positive_regulation PLAU HSPA5 24314144 222354 Positive_regulation PLAU HSPA5 24314144 222355 Positive_regulation PLAU HSPA5 24314144 222356 Positive_regulation PLAU HSPA5 24314144 222357 Positive_regulation PLAU HSPA5 24314144 222361 Positive_regulation PLAU HSPA5 24314144 222366 Positive_regulation PLAU HSPA5 24314144 222368 Positive_regulation PLAU HSPA5 24314144 222372 Positive_regulation PLAU HSPA5 24314144 222373 Positive_regulation PLAU HTR1B 25170871 3004001 Positive_regulation PLAU IGF1 24204158 2122327 Positive_regulation PLAU IGF1R 24005867 1110940 Positive_regulation PLAU IL10 10408691 414740 Positive_regulation PLAU IL10 7535337 1590114 Positive_regulation PLAU IL10 8826848 445633 Positive_regulation PLAU IL11 10408691 414741 Positive_regulation PLAU IL11 7535337 1590115 Positive_regulation PLAU IL11 8826848 445634 Positive_regulation PLAU IL13 10408691 414742 Positive_regulation PLAU IL13 11560996 1520948 Positive_regulation PLAU IL13 7535337 1590116 Positive_regulation PLAU IL13 8826848 445635 Positive_regulation PLAU IL13 9635840 447108 Positive_regulation PLAU IL15 10408691 414743 Positive_regulation PLAU IL15 7535337 1590117 Positive_regulation PLAU IL15 8826848 445636 Positive_regulation PLAU IL16 10408691 414744 Positive_regulation PLAU IL16 7535337 1590118 Positive_regulation PLAU IL16 8826848 445637 Positive_regulation PLAU IL18 10408691 414745 Positive_regulation PLAU IL18 7535337 1590119 Positive_regulation PLAU IL18 8826848 445638 Positive_regulation PLAU IL19 10408691 414746 Positive_regulation PLAU IL19 7535337 1590120 Positive_regulation PLAU IL19 8826848 445639 Positive_regulation PLAU IL1A 16504015 278989 Positive_regulation PLAU IL1A 19926662 1035609 Positive_regulation PLAU IL1A 22662010 95284 Positive_regulation PLAU IL1A 22710193 2253031 Positive_regulation PLAU IL1A 22710193 2253032 Positive_regulation PLAU IL1A 22710193 2253034 Positive_regulation PLAU IL1A 22710193 2253066 Positive_regulation PLAU IL1A 22963460 1698823 Positive_regulation PLAU IL1A 23502002 2086216 Positive_regulation PLAU IL1A 23597113 128299 Positive_regulation PLAU IL1B 24040137 2846002 Positive_regulation PLAU IL2 10408691 414747 Positive_regulation PLAU IL2 7535337 1590121 Positive_regulation PLAU IL2 8826848 445640 Positive_regulation PLAU IL20 10408691 414748 Positive_regulation PLAU IL20 7535337 1590122 Positive_regulation PLAU IL20 8826848 445641 Positive_regulation PLAU IL21 10408691 414749 Positive_regulation PLAU IL21 7535337 1590123 Positive_regulation PLAU IL21 8826848 445642 Positive_regulation PLAU IL22 10408691 414730 Positive_regulation PLAU IL22 7535337 1590106 Positive_regulation PLAU IL22 8826848 445625 Positive_regulation PLAU IL24 10408691 414726 Positive_regulation PLAU IL24 7535337 1590104 Positive_regulation PLAU IL24 8826848 445623 Positive_regulation PLAU IL25 10408691 414729 Positive_regulation PLAU IL25 7535337 1590105 Positive_regulation PLAU IL25 8826848 445624 Positive_regulation PLAU IL26 10408691 414734 Positive_regulation PLAU IL26 7535337 1590110 Positive_regulation PLAU IL26 8826848 445629 Positive_regulation PLAU IL27 10408691 414735 Positive_regulation PLAU IL27 7535337 1590111 Positive_regulation PLAU IL27 8826848 445630 Positive_regulation PLAU IL3 10408691 414750 Positive_regulation PLAU IL3 7535337 1590124 Positive_regulation PLAU IL3 8826848 445643 Positive_regulation PLAU IL31 10408691 414736 Positive_regulation PLAU IL31 7535337 1590112 Positive_regulation PLAU IL31 8826848 445631 Positive_regulation PLAU IL32 10408691 414733 Positive_regulation PLAU IL32 7535337 1590109 Positive_regulation PLAU IL32 8826848 445628 Positive_regulation PLAU IL33 10408691 414732 Positive_regulation PLAU IL33 7535337 1590108 Positive_regulation PLAU IL33 8826848 445627 Positive_regulation PLAU IL34 10408691 414739 Positive_regulation PLAU IL34 7535337 1590113 Positive_regulation PLAU IL34 8826848 445632 Positive_regulation PLAU IL37 10408691 414731 Positive_regulation PLAU IL37 7535337 1590107 Positive_regulation PLAU IL37 8826848 445626 Positive_regulation PLAU IL4 10408691 414751 Positive_regulation PLAU IL4 7535337 1590125 Positive_regulation PLAU IL4 8826848 445644 Positive_regulation PLAU IL5 10408691 414752 Positive_regulation PLAU IL5 7535337 1590126 Positive_regulation PLAU IL5 8826848 445645 Positive_regulation PLAU IL6 10408691 414753 Positive_regulation PLAU IL6 22566887 899600 Positive_regulation PLAU IL6 24381786 1152470 Positive_regulation PLAU IL6 7535337 1590127 Positive_regulation PLAU IL6 8826848 445646 Positive_regulation PLAU IL7 10408691 414754 Positive_regulation PLAU IL7 7535337 1590128 Positive_regulation PLAU IL7 8826848 445647 Positive_regulation PLAU IL8 10408691 414755 Positive_regulation PLAU IL8 7535337 1590129 Positive_regulation PLAU IL8 8826848 445648 Positive_regulation PLAU IL8 PMC2756345 496134 Positive_regulation PLAU IL9 10408691 414756 Positive_regulation PLAU IL9 7535337 1590130 Positive_regulation PLAU IL9 8826848 445649 Positive_regulation PLAU ILF3 22986534 2148763 Positive_regulation PLAU ILF3 22986534 2148764 Positive_regulation PLAU ILF3 22986534 2148765 Positive_regulation PLAU ILF3 22986534 2148766 Positive_regulation PLAU ILF3 22986534 2148767 Positive_regulation PLAU ILF3 22986534 2148768 Positive_regulation PLAU ILF3 22986534 2148769 Positive_regulation PLAU ILF3 22986534 2148776 Positive_regulation PLAU ILF3 22986534 2148777 Positive_regulation PLAU ILF3 22986534 2148778 Positive_regulation PLAU ILF3 22986534 2148782 Positive_regulation PLAU ILF3 22986534 2148784 Positive_regulation PLAU ILK 23645983 3188970 Positive_regulation PLAU JAG1 25309874 948776 Positive_regulation PLAU JUN 22986534 2148785 Positive_regulation PLAU JUN 23562655 829805 Positive_regulation PLAU JUN 25200076 2104640 Positive_regulation PLAU KAL1 24189182 787856 Positive_regulation PLAU KAL1 24189182 787905 Positive_regulation PLAU KLK4 23451143 2758223 Positive_regulation PLAU KLK4 23451143 2758248 Positive_regulation PLAU KLK4 23451143 2758250 Positive_regulation PLAU KLKB1 25212966 475604 Positive_regulation PLAU KRAS 11437413 419200 Positive_regulation PLAU KRAS 20067638 255178 Positive_regulation PLAU LCK 22988500 1689663 Positive_regulation PLAU LCK 24155921 2871365 Positive_regulation PLAU LPA 21423677 798532 Positive_regulation PLAU LPA 23574936 1105325 Positive_regulation PLAU LRP1 19008962 2400768 Positive_regulation PLAU LRPAP1 11266465 1269114 Positive_regulation PLAU MAP2K4 24466137 2913681 Positive_regulation PLAU MAPK1 17327908 2374702 Positive_regulation PLAU MAPK1 21124918 2484607 Positive_regulation PLAU MAPK1 21813027 260774 Positive_regulation PLAU MAPK1 22952779 2684064 Positive_regulation PLAU MAPK1 23349823 2743432 Positive_regulation PLAU MAPK1 23940799 2832493 Positive_regulation PLAU MAPK1 23967071 2834288 Positive_regulation PLAU MAPK10 17327908 2374703 Positive_regulation PLAU MAPK10 21124918 2484608 Positive_regulation PLAU MAPK10 21813027 260775 Positive_regulation PLAU MAPK10 23349823 2743433 Positive_regulation PLAU MAPK10 23940799 2832494 Positive_regulation PLAU MAPK10 23967071 2834289 Positive_regulation PLAU MAPK11 17327908 2374704 Positive_regulation PLAU MAPK11 21124918 2484609 Positive_regulation PLAU MAPK11 21813027 260776 Positive_regulation PLAU MAPK11 23349823 2743434 Positive_regulation PLAU MAPK11 23940799 2832495 Positive_regulation PLAU MAPK11 23967071 2834290 Positive_regulation PLAU MAPK12 17327908 2374705 Positive_regulation PLAU MAPK12 21124918 2484610 Positive_regulation PLAU MAPK12 21813027 260777 Positive_regulation PLAU MAPK12 23349823 2743435 Positive_regulation PLAU MAPK12 23940799 2832496 Positive_regulation PLAU MAPK12 23967071 2834291 Positive_regulation PLAU MAPK13 17327908 2374706 Positive_regulation PLAU MAPK13 21124918 2484611 Positive_regulation PLAU MAPK13 21813027 260778 Positive_regulation PLAU MAPK13 23349823 2743436 Positive_regulation PLAU MAPK13 23940799 2832497 Positive_regulation PLAU MAPK13 23967071 2834292 Positive_regulation PLAU MAPK14 17327908 2374707 Positive_regulation PLAU MAPK14 21124918 2484612 Positive_regulation PLAU MAPK14 21813027 260779 Positive_regulation PLAU MAPK14 23349823 2743437 Positive_regulation PLAU MAPK14 23940799 2832498 Positive_regulation PLAU MAPK14 23967071 2834293 Positive_regulation PLAU MAPK15 17327908 2374701 Positive_regulation PLAU MAPK15 21124918 2484606 Positive_regulation PLAU MAPK15 21813027 260770 Positive_regulation PLAU MAPK15 23349823 2743431 Positive_regulation PLAU MAPK15 23940799 2832492 Positive_regulation PLAU MAPK15 23967071 2834287 Positive_regulation PLAU MAPK3 17327908 2374708 Positive_regulation PLAU MAPK3 19808845 811566 Positive_regulation PLAU MAPK3 21124918 2484613 Positive_regulation PLAU MAPK3 21799677 812910 Positive_regulation PLAU MAPK3 21813027 260780 Positive_regulation PLAU MAPK3 22952779 2684065 Positive_regulation PLAU MAPK3 23349823 2743438 Positive_regulation PLAU MAPK3 23940799 2832499 Positive_regulation PLAU MAPK3 23967071 2834294 Positive_regulation PLAU MAPK4 17327908 2374709 Positive_regulation PLAU MAPK4 21124918 2484614 Positive_regulation PLAU MAPK4 21813027 260781 Positive_regulation PLAU MAPK4 23349823 2743439 Positive_regulation PLAU MAPK4 23940799 2832500 Positive_regulation PLAU MAPK4 23967071 2834295 Positive_regulation PLAU MAPK6 17327908 2374710 Positive_regulation PLAU MAPK6 21124918 2484615 Positive_regulation PLAU MAPK6 21813027 260782 Positive_regulation PLAU MAPK6 23349823 2743440 Positive_regulation PLAU MAPK6 23940799 2832501 Positive_regulation PLAU MAPK6 23967071 2834296 Positive_regulation PLAU MAPK7 17327908 2374711 Positive_regulation PLAU MAPK7 21124918 2484616 Positive_regulation PLAU MAPK7 21813027 260783 Positive_regulation PLAU MAPK7 23349823 2743441 Positive_regulation PLAU MAPK7 23940799 2832502 Positive_regulation PLAU MAPK7 23967071 2834297 Positive_regulation PLAU MAPK8 17327908 2374712 Positive_regulation PLAU MAPK8 21124918 2484617 Positive_regulation PLAU MAPK8 21813027 260784 Positive_regulation PLAU MAPK8 21859479 1229568 Positive_regulation PLAU MAPK8 21859479 1229597 Positive_regulation PLAU MAPK8 21859479 1229598 Positive_regulation PLAU MAPK8 23349823 2743442 Positive_regulation PLAU MAPK8 23940799 2832503 Positive_regulation PLAU MAPK8 23967071 2834298 Positive_regulation PLAU MAPK9 17327908 2374713 Positive_regulation PLAU MAPK9 21124918 2484618 Positive_regulation PLAU MAPK9 21813027 260785 Positive_regulation PLAU MAPK9 23349823 2743443 Positive_regulation PLAU MAPK9 23940799 2832504 Positive_regulation PLAU MAPK9 23967071 2834299 Positive_regulation PLAU MCM2 23597113 128198 Positive_regulation PLAU MCM2 23597113 128199 Positive_regulation PLAU MCM2 23597113 128200 Positive_regulation PLAU MCM2 23597113 128236 Positive_regulation PLAU MCM2 23597113 128237 Positive_regulation PLAU MCM2 23597113 128275 Positive_regulation PLAU MCM2 23597113 128276 Positive_regulation PLAU MCM2 23597113 128300 Positive_regulation PLAU MCM2 23597113 128301 Positive_regulation PLAU MCM2 23597113 128302 Positive_regulation PLAU MCM2 23597113 128322 Positive_regulation PLAU MCM2 23597113 128323 Positive_regulation PLAU MCM2 23597113 128344 Positive_regulation PLAU MCM2 23597113 128345 Positive_regulation PLAU MCM3 23597113 128201 Positive_regulation PLAU MCM3 23597113 128202 Positive_regulation PLAU MCM3 23597113 128203 Positive_regulation PLAU MCM3 23597113 128238 Positive_regulation PLAU MCM3 23597113 128239 Positive_regulation PLAU MCM3 23597113 128277 Positive_regulation PLAU MCM3 23597113 128278 Positive_regulation PLAU MCM3 23597113 128303 Positive_regulation PLAU MCM3 23597113 128304 Positive_regulation PLAU MCM3 23597113 128305 Positive_regulation PLAU MCM3 23597113 128324 Positive_regulation PLAU MCM3 23597113 128325 Positive_regulation PLAU MCM3 23597113 128346 Positive_regulation PLAU MCM3 23597113 128347 Positive_regulation PLAU MCM4 23597113 128204 Positive_regulation PLAU MCM4 23597113 128205 Positive_regulation PLAU MCM4 23597113 128206 Positive_regulation PLAU MCM4 23597113 128240 Positive_regulation PLAU MCM4 23597113 128241 Positive_regulation PLAU MCM4 23597113 128279 Positive_regulation PLAU MCM4 23597113 128280 Positive_regulation PLAU MCM4 23597113 128306 Positive_regulation PLAU MCM4 23597113 128307 Positive_regulation PLAU MCM4 23597113 128308 Positive_regulation PLAU MCM4 23597113 128326 Positive_regulation PLAU MCM4 23597113 128327 Positive_regulation PLAU MCM4 23597113 128348 Positive_regulation PLAU MCM4 23597113 128349 Positive_regulation PLAU MCM5 23597113 128207 Positive_regulation PLAU MCM5 23597113 128208 Positive_regulation PLAU MCM5 23597113 128209 Positive_regulation PLAU MCM5 23597113 128242 Positive_regulation PLAU MCM5 23597113 128243 Positive_regulation PLAU MCM5 23597113 128281 Positive_regulation PLAU MCM5 23597113 128282 Positive_regulation PLAU MCM5 23597113 128309 Positive_regulation PLAU MCM5 23597113 128310 Positive_regulation PLAU MCM5 23597113 128311 Positive_regulation PLAU MCM5 23597113 128328 Positive_regulation PLAU MCM5 23597113 128329 Positive_regulation PLAU MCM5 23597113 128350 Positive_regulation PLAU MCM5 23597113 128351 Positive_regulation PLAU MCM6 23597113 128210 Positive_regulation PLAU MCM6 23597113 128211 Positive_regulation PLAU MCM6 23597113 128212 Positive_regulation PLAU MCM6 23597113 128244 Positive_regulation PLAU MCM6 23597113 128245 Positive_regulation PLAU MCM6 23597113 128283 Positive_regulation PLAU MCM6 23597113 128284 Positive_regulation PLAU MCM6 23597113 128312 Positive_regulation PLAU MCM6 23597113 128313 Positive_regulation PLAU MCM6 23597113 128314 Positive_regulation PLAU MCM6 23597113 128330 Positive_regulation PLAU MCM6 23597113 128331 Positive_regulation PLAU MCM6 23597113 128352 Positive_regulation PLAU MCM6 23597113 128353 Positive_regulation PLAU MCM7 23597113 128213 Positive_regulation PLAU MCM7 23597113 128214 Positive_regulation PLAU MCM7 23597113 128215 Positive_regulation PLAU MCM7 23597113 128246 Positive_regulation PLAU MCM7 23597113 128247 Positive_regulation PLAU MCM7 23597113 128285 Positive_regulation PLAU MCM7 23597113 128286 Positive_regulation PLAU MCM7 23597113 128315 Positive_regulation PLAU MCM7 23597113 128316 Positive_regulation PLAU MCM7 23597113 128317 Positive_regulation PLAU MCM7 23597113 128332 Positive_regulation PLAU MCM7 23597113 128333 Positive_regulation PLAU MCM7 23597113 128354 Positive_regulation PLAU MCM7 23597113 128355 Positive_regulation PLAU MET 16646560 1711375 Positive_regulation PLAU MET 19497102 1503748 Positive_regulation PLAU MET 19497102 1503773 Positive_regulation PLAU MIEN1 19503095 2125538 Positive_regulation PLAU MIEN1 19503095 2125543 Positive_regulation PLAU MMP2 24098421 2856298 Positive_regulation PLAU MMP2 24709902 617320 Positive_regulation PLAU MMP9 24978435 504744 Positive_regulation PLAU MRC2 12952933 1296524 Positive_regulation PLAU MUT 23597113 128216 Positive_regulation PLAU MUT 23597113 128248 Positive_regulation PLAU MUT 23597113 128249 Positive_regulation PLAU MUT 23597113 128250 Positive_regulation PLAU MUT 23597113 128318 Positive_regulation PLAU MUT 23597113 128319 Positive_regulation PLAU MUT 23597113 128356 Positive_regulation PLAU MUT 23597113 128393 Positive_regulation PLAU MYLIP 24256616 270510 Positive_regulation PLAU MYLIP 24330766 1870574 Positive_regulation PLAU MYLIP 24330766 1870577 Positive_regulation PLAU MYLK 10402467 1248046 Positive_regulation PLAU MYOCD 23125522 1225546 Positive_regulation PLAU NFKB1 23574936 1105322 Positive_regulation PLAU NFKB1 23984088 1150988 Positive_regulation PLAU NOTCH1 22004682 1863744 Positive_regulation PLAU NOTCH1 22004682 1863813 Positive_regulation PLAU NOTCH1 25309874 948777 Positive_regulation PLAU NOTCH2 25309874 948778 Positive_regulation PLAU NOTCH3 25309874 948779 Positive_regulation PLAU NOTCH4 25309874 948780 Positive_regulation PLAU NRAS 11437413 419201 Positive_regulation PLAU NRAS 20067638 255179 Positive_regulation PLAU OSM 24381786 1152471 Positive_regulation PLAU OSM 8691152 1598561 Positive_regulation PLAU PAICS 19789215 811512 Positive_regulation PLAU PDCD4 25144746 3001225 Positive_regulation PLAU PIK3CA 17264880 2374614 Positive_regulation PLAU PIK3CA 17327908 2374714 Positive_regulation PLAU PIK3CA 19384426 668927 Positive_regulation PLAU PIK3CA 21124918 2484619 Positive_regulation PLAU PIK3CA 21813027 260786 Positive_regulation PLAU PIK3CA 23349823 2743444 Positive_regulation PLAU PIK3CA 23383143 2748436 Positive_regulation PLAU PIK3CA 23661031 735563 Positive_regulation PLAU PIK3CA 24629239 1873153 Positive_regulation PLAU PIK3R1 17264880 2374615 Positive_regulation PLAU PIK3R1 17327908 2374715 Positive_regulation PLAU PIK3R1 19384426 668928 Positive_regulation PLAU PIK3R1 21124918 2484620 Positive_regulation PLAU PIK3R1 21813027 260787 Positive_regulation PLAU PIK3R1 23349823 2743445 Positive_regulation PLAU PIK3R1 23383143 2748437 Positive_regulation PLAU PIK3R1 23661031 735564 Positive_regulation PLAU PIK3R1 24629239 1873154 Positive_regulation PLAU PLAT 1918136 1363667 Positive_regulation PLAU PLAUR 10402467 1248041 Positive_regulation PLAU PLAUR 10402467 1248053 Positive_regulation PLAU PLAUR 10917542 417289 Positive_regulation PLAU PLAUR 11257116 1267899 Positive_regulation PLAU PLAUR 12556966 422142 Positive_regulation PLAU PLAUR 12668656 1291666 Positive_regulation PLAU PLAUR 12865932 422948 Positive_regulation PLAU PLAUR 12952933 1296526 Positive_regulation PLAU PLAUR 15050027 1694896 Positive_regulation PLAU PLAUR 15617575 656483 Positive_regulation PLAU PLAUR 17257442 460649 Positive_regulation PLAU PLAUR 19483730 2125490 Positive_regulation PLAU PLAUR 19672469 3074970 Positive_regulation PLAU PLAUR 21304816 2499935 Positive_regulation PLAU PLAUR 21535874 3207273 Positive_regulation PLAU PLAUR 21798065 1505392 Positive_regulation PLAU PLAUR 22139533 3177832 Positive_regulation PLAU PLAUR 22363796 2601968 Positive_regulation PLAU PLAUR 22470492 2614390 Positive_regulation PLAU PLAUR 22470492 2614394 Positive_regulation PLAU PLAUR 23076139 518466 Positive_regulation PLAU PLAUR 23125522 1225558 Positive_regulation PLAU PLAUR 23125522 1225560 Positive_regulation PLAU PLAUR 23843896 3177337 Positive_regulation PLAU PLAUR 23864708 1816997 Positive_regulation PLAU PLAUR 23951261 2834091 Positive_regulation PLAU PLAUR 23984088 1150966 Positive_regulation PLAU PLAUR 24129242 442095 Positive_regulation PLAU PLAUR 24466048 2912477 Positive_regulation PLAU PLAUR 25212966 475603 Positive_regulation PLAU PLAUR 8522616 1449796 Positive_regulation PLAU PLAUR 9151681 1460008 Positive_regulation PLAU PLAUR 9566979 1467642 Positive_regulation PLAU PLG 11056680 97968 Positive_regulation PLAU PLG 12617738 658452 Positive_regulation PLAU PLG 16524486 249158 Positive_regulation PLAU PLG 16646560 1711384 Positive_regulation PLAU PLG 16916471 249581 Positive_regulation PLAU PLG 17286208 1639516 Positive_regulation PLAU PLG 20514206 683569 Positive_regulation PLAU PLG 22069569 3182502 Positive_regulation PLAU PLG 22754528 951921 Positive_regulation PLAU PLG 22792020 686361 Positive_regulation PLAU PLG 22919385 1674160 Positive_regulation PLAU PLG 23853591 3062983 Positive_regulation PLAU PLG 23853591 3062986 Positive_regulation PLAU PLG 23853591 3062999 Positive_regulation PLAU PLG 24194929 2872723 Positive_regulation PLAU PLG 24681666 2188614 Positive_regulation PLAU PLG 25147500 870743 Positive_regulation PLAU PLG 3730252 443538 Positive_regulation PLAU PLG 7547226 443895 Positive_regulation PLAU PLG 8382511 444881 Positive_regulation PLAU PLG 9472634 446875 Positive_regulation PLAU POLDIP2 19497102 1503768 Positive_regulation PLAU POLDIP2 23967071 2834286 Positive_regulation PLAU PRB1 23485561 1812808 Positive_regulation PLAU PRB1 23485561 1812917 Positive_regulation PLAU PRB1 23485561 1812925 Positive_regulation PLAU PRB2 23485561 1812809 Positive_regulation PLAU PRB2 23485561 1812918 Positive_regulation PLAU PRB2 23485561 1812926 Positive_regulation PLAU PRB3 23485561 1812810 Positive_regulation PLAU PRB3 23485561 1812919 Positive_regulation PLAU PRB3 23485561 1812927 Positive_regulation PLAU PRB4 23485561 1812811 Positive_regulation PLAU PRB4 23485561 1812920 Positive_regulation PLAU PRB4 23485561 1812928 Positive_regulation PLAU PRDX6 17980029 461750 Positive_regulation PLAU PTGS2 16831226 249512 Positive_regulation PLAU PTGS2 16916471 249583 Positive_regulation PLAU PTGS2 21592330 411479 Positive_regulation PLAU PTGS2 21592330 411493 Positive_regulation PLAU PTGS2 21592330 411498 Positive_regulation PLAU RAC1 12952933 1296527 Positive_regulation PLAU RAC1 20067638 255083 Positive_regulation PLAU RAC1 20067638 255084 Positive_regulation PLAU RAC1 20067638 255114 Positive_regulation PLAU RAC1 20067638 255153 Positive_regulation PLAU RAC1 20067638 255164 Positive_regulation PLAU RAC1 20067638 255171 Positive_regulation PLAU RAC2 12952933 1296528 Positive_regulation PLAU RAC3 12952933 1296529 Positive_regulation PLAU RALA 21714887 482252 Positive_regulation PLAU RELA 23574936 1105323 Positive_regulation PLAU RELA 23984088 1150989 Positive_regulation PLAU RHOA 21858203 2546884 Positive_regulation PLAU RHOA 21858203 2546885 Positive_regulation PLAU RHOA 21858203 2546887 Positive_regulation PLAU RNF19A 18629100 655562 Positive_regulation PLAU RNF19A 21799677 812909 Positive_regulation PLAU S100A4 15900299 426115 Positive_regulation PLAU S100A6 23485561 1812807 Positive_regulation PLAU S100A6 23485561 1812916 Positive_regulation PLAU SDS 24644264 492663 Positive_regulation PLAU SEMA3C 16641895 427512 Positive_regulation PLAU SEMA5A 23661031 735547 Positive_regulation PLAU SEMA5A 23661031 735548 Positive_regulation PLAU SERPINB2 19442270 247679 Positive_regulation PLAU SERPINB2 23878812 182440 Positive_regulation PLAU SERPINB2 24999729 2986618 Positive_regulation PLAU SERPINE1 17264880 2374618 Positive_regulation PLAU SERPINE1 22139533 3177831 Positive_regulation PLAU SERPINE1 22919385 1674159 Positive_regulation PLAU SERPINE1 23118508 1225458 Positive_regulation PLAU SERPINE1 23878812 182439 Positive_regulation PLAU SERPINE1 23898467 864159 Positive_regulation PLAU SERPINE1 24340014 2894518 Positive_regulation PLAU SERPINE1 24494029 1240282 Positive_regulation PLAU SERPINE1 24999729 2986617 Positive_regulation PLAU SETD2 23241400 1231831 Positive_regulation PLAU SETD2 24216979 500594 Positive_regulation PLAU SLC25A16 11266465 1269121 Positive_regulation PLAU SMAD3 23984088 1150990 Positive_regulation PLAU SMAD4 23984088 1151026 Positive_regulation PLAU SPHK1 25309325 871471 Positive_regulation PLAU SPHK2 25309325 871472 Positive_regulation PLAU SPP1 16887003 460073 Positive_regulation PLAU SPP1 20868520 1859520 Positive_regulation PLAU SPP1 23289017 1061023 Positive_regulation PLAU SPP1 23289017 1061028 Positive_regulation PLAU SPP1 23289017 1061029 Positive_regulation PLAU SRF 23125522 1225545 Positive_regulation PLAU ST14 18219094 736111 Positive_regulation PLAU ST14 23675430 2792841 Positive_regulation PLAU ST14 23675430 2792863 Positive_regulation PLAU ST14 24146945 2869001 Positive_regulation PLAU ST14 24705933 2949353 Positive_regulation PLAU ST14 25506199 490191 Positive_regulation PLAU TAT 24911386 2012028 Positive_regulation PLAU TAT 25295247 200731 Positive_regulation PLAU TCF12 14760364 424236 Positive_regulation PLAU TCF15 14760364 424237 Positive_regulation PLAU TCF19 14760364 424238 Positive_regulation PLAU TCF20 14760364 424239 Positive_regulation PLAU TCF21 14760364 424240 Positive_regulation PLAU TCF23 14760364 424244 Positive_regulation PLAU TCF24 14760364 424246 Positive_regulation PLAU TCF25 14760364 424245 Positive_regulation PLAU TCF3 14760364 424241 Positive_regulation PLAU TCF4 14760364 424242 Positive_regulation PLAU TCF7 14760364 424243 Positive_regulation PLAU TCN1 24314144 222359 Positive_regulation PLAU TCN2 24314144 222360 Positive_regulation PLAU TGFA 9484807 446926 Positive_regulation PLAU TGFB1 9472634 446861 Positive_regulation PLAU TGFB1 9472634 446866 Positive_regulation PLAU THBS1 10917542 417306 Positive_regulation PLAU TMPRSS4 24748857 1021886 Positive_regulation PLAU TNF 10408691 414727 Positive_regulation PLAU TNF 10408691 414728 Positive_regulation PLAU TNF 1714936 1543585 Positive_regulation PLAU TNF 22662010 95283 Positive_regulation PLAU TNF 22662010 95286 Positive_regulation PLAU TNF 22927998 2681289 Positive_regulation PLAU TNF 22927998 2681292 Positive_regulation PLAU TNF 22927998 2681295 Positive_regulation PLAU TNF 22927998 2681300 Positive_regulation PLAU TNF 22927998 2681302 Positive_regulation PLAU TNF 8826848 445611 Positive_regulation PLAU TNF 8826848 445616 Positive_regulation PLAU TNF 8826848 445617 Positive_regulation PLAU TNF 8826848 445618 Positive_regulation PLAU TNF 8826848 445621 Positive_regulation PLAU TNF 9764576 447920 Positive_regulation PLAU TNFRSF6B 24107265 1870042 Positive_regulation PLAU TNFRSF6B 24107265 1870051 Positive_regulation PLAU TNFSF10 24481457 571853 Positive_regulation PLAU TNFSF11 20010942 434239 Positive_regulation PLAU VEGFA 12556241 1843387 Positive_regulation PLAU VEGFA 18182986 429802 Positive_regulation PLAU VEGFA 21219633 659774 Positive_regulation PLAU VEGFA 21304816 2499934 Positive_regulation PLAU VEGFA 9635853 447185 Positive_regulation PLAU VTN 8522616 1449795 Positive_regulation PLAU VTN 8830783 1456553 Positive_regulation PLAUR EPHB2 18725541 1355202 Positive_regulation PLAUR EPHB2 20644732 2456137 Positive_regulation PLAUR EPHB2 23076139 518467 Positive_regulation PLAUR ITGB2 7535337 1590102 Positive_regulation PLAUR PLAU 10402467 1248042 Positive_regulation PLAUR PLAU 10402467 1248054 Positive_regulation PLAUR PLAU 10496343 415326 Positive_regulation PLAUR PLAU 10508858 1250920 Positive_regulation PLAUR PLAU 12952933 1296532 Positive_regulation PLAUR PLAU 15617575 656484 Positive_regulation PLAUR PLAU 18362935 430471 Positive_regulation PLAUR PLAU 19008962 2400770 Positive_regulation PLAUR PLAU 19008962 2400776 Positive_regulation PLAUR PLAU 19703758 1703364 Positive_regulation PLAUR PLAU 19893210 736370 Positive_regulation PLAUR PLAU 20374633 3118765 Positive_regulation PLAUR PLAU 22139533 3177833 Positive_regulation PLAUR PLAU 22315598 1673353 Positive_regulation PLAUR PLAU 22470492 2614395 Positive_regulation PLAUR PLAU 22479587 2616193 Positive_regulation PLAUR PLAU 23724131 2799139 Positive_regulation PLAUR PLAU 23936774 182554 Positive_regulation PLAUR PLAU 23984088 1150967 Positive_regulation PLAUR PLAU 23984088 1150968 Positive_regulation PLAUR PLAU 24453475 1916745 Positive_regulation PLAUR PLAU 8830783 1456554 Positive_regulation PLAUR RAB31 25472813 1486018 Positive_regulation PLAUR TLR7 21998707 2562083 Positive_regulation PLAUR TNF 23840908 2818841 Positive_regulation PLAUR TNF 24618154 1728531 Positive_regulation PLAUR TNF 8826848 445622 Positive_regulation PLCH1 NES 15251038 277795 Positive_regulation PLD1 GPR115 24995811 1765764 Positive_regulation PLD1 GPR132 24995811 1765753 Positive_regulation PLD1 GPR87 24995811 1765833 Positive_regulation PLD1 MAP2K6 23549262 1104410 Positive_regulation PLD1 TNF 1658188 1539811 Positive_regulation PLD1 TNF 1658188 1539812 Positive_regulation PLD1 TNF 1658188 1539824 Positive_regulation PLD1 TNF 22257771 3160815 Positive_regulation PLD2 GPR115 24995811 1765857 Positive_regulation PLD2 GPR132 24995811 1765846 Positive_regulation PLD2 GPR87 24995811 1765926 Positive_regulation PLD2 MAP2K6 23549262 1104427 Positive_regulation PLD2 TNF 1658188 1539813 Positive_regulation PLD2 TNF 1658188 1539814 Positive_regulation PLD2 TNF 1658188 1539825 Positive_regulation PLD3 GPR115 24995811 1764894 Positive_regulation PLD3 GPR132 24995811 1764883 Positive_regulation PLD3 GPR87 24995811 1764963 Positive_regulation PLD3 MAP2K6 23549262 1104242 Positive_regulation PLD3 TNF 1658188 1539801 Positive_regulation PLD3 TNF 1658188 1539802 Positive_regulation PLD3 TNF 1658188 1539820 Positive_regulation PLD4 GPR115 24995811 1765197 Positive_regulation PLD4 GPR132 24995811 1765186 Positive_regulation PLD4 GPR87 24995811 1765266 Positive_regulation PLD4 MAP2K6 23549262 1104261 Positive_regulation PLD4 TNF 1658188 1539803 Positive_regulation PLD4 TNF 1658188 1539804 Positive_regulation PLD4 TNF 1658188 1539821 Positive_regulation PLD5 GPR115 24995811 1765296 Positive_regulation PLD5 GPR132 24995811 1765285 Positive_regulation PLD5 GPR87 24995811 1765365 Positive_regulation PLD5 MAP2K6 23549262 1104294 Positive_regulation PLD5 TLR7 25398128 3027504 Positive_regulation PLD5 TNF 1658188 1539805 Positive_regulation PLD5 TNF 1658188 1539806 Positive_regulation PLD5 TNF 1658188 1539822 Positive_regulation PLD6 GPR115 24995811 1765407 Positive_regulation PLD6 GPR132 24995811 1765396 Positive_regulation PLD6 GPR87 24995811 1765476 Positive_regulation PLD6 MAP2K6 23549262 1104311 Positive_regulation PLD6 TNF 1658188 1539807 Positive_regulation PLD6 TNF 1658188 1539808 Positive_regulation PLD6 TNF 1658188 1539823 Positive_regulation PLEC EPHB2 24499192 367707 Positive_regulation PLEC MUC16 23915402 3113878 Positive_regulation PLG EPHB2 23875077 1615816 Positive_regulation PLG EPHB2 23984088 1150969 Positive_regulation PLG IL1B 11161396 418298 Positive_regulation PLG IL1B 15559369 630336 Positive_regulation PLG LAMB3 23097597 1225255 Positive_regulation PLG MMP28 23008698 833307 Positive_regulation PLG MMP28 24465147 842061 Positive_regulation PLG MMP7 23008698 833322 Positive_regulation PLG MMP7 24465147 842076 Positive_regulation PLG PLAT 11044361 417980 Positive_regulation PLG PLAT 11266468 1269211 Positive_regulation PLG PLAT 16524486 249156 Positive_regulation PLG PLAT 16968541 3177985 Positive_regulation PLG PLAT 17134505 312963 Positive_regulation PLG PLAT 17134505 312974 Positive_regulation PLG PLAT 17286208 1639513 Positive_regulation PLG PLAT 17576803 1341627 Positive_regulation PLG PLAT 17641727 1212531 Positive_regulation PLG PLAT 17641727 1212532 Positive_regulation PLG PLAT 17917109 1889775 Positive_regulation PLG PLAT 18813339 2396829 Positive_regulation PLG PLAT 18818748 2396848 Positive_regulation PLG PLAT 19492051 2418025 Positive_regulation PLG PLAT 19672469 3074969 Positive_regulation PLG PLAT 19845941 1852152 Positive_regulation PLG PLAT 20162032 927738 Positive_regulation PLG PLAT 20162032 927757 Positive_regulation PLG PLAT 20226053 365846 Positive_regulation PLG PLAT 20407627 3208866 Positive_regulation PLG PLAT 20539748 3190555 Positive_regulation PLG PLAT 20552372 3175171 Positive_regulation PLG PLAT 20553606 256291 Positive_regulation PLG PLAT 20717705 494117 Positive_regulation PLG PLAT 20965889 805371 Positive_regulation PLG PLAT 2104856 1382731 Positive_regulation PLG PLAT 21179199 2487538 Positive_regulation PLG PLAT 21241489 659803 Positive_regulation PLG PLAT 21251205 1692168 Positive_regulation PLG PLAT 21383941 649491 Positive_regulation PLG PLAT 2182649 1390587 Positive_regulation PLG PLAT 2182649 1390589 Positive_regulation PLG PLAT 21827709 1835931 Positive_regulation PLG PLAT 21931850 2555047 Positive_regulation PLG PLAT 22022509 2563330 Positive_regulation PLG PLAT 22185689 247923 Positive_regulation PLG PLAT 22291507 650186 Positive_regulation PLG PLAT 22389825 1152777 Positive_regulation PLG PLAT 22419838 163409 Positive_regulation PLG PLAT 22701432 958011 Positive_regulation PLG PLAT 22754528 951915 Positive_regulation PLG PLAT 22802985 2221978 Positive_regulation PLG PLAT 22870270 2672131 Positive_regulation PLG PLAT 23047269 3125918 Positive_regulation PLG PLAT 23097646 935149 Positive_regulation PLG PLAT 23118495 1225260 Positive_regulation PLG PLAT 23118506 1225366 Positive_regulation PLG PLAT 23118506 1225372 Positive_regulation PLG PLAT 23118506 1225375 Positive_regulation PLG PLAT 23118506 1225377 Positive_regulation PLG PLAT 23118509 1225485 Positive_regulation PLG PLAT 23118509 1225486 Positive_regulation PLG PLAT 23118509 1225487 Positive_regulation PLG PLAT 23118509 1225488 Positive_regulation PLG PLAT 23118509 1225499 Positive_regulation PLG PLAT 23118509 1225502 Positive_regulation PLG PLAT 23118509 1225512 Positive_regulation PLG PLAT 23118509 1225516 Positive_regulation PLG PLAT 23118509 1225519 Positive_regulation PLG PLAT 23118509 1225520 Positive_regulation PLG PLAT 23118509 1225521 Positive_regulation PLG PLAT 23118509 1225522 Positive_regulation PLG PLAT 23118518 1225534 Positive_regulation PLG PLAT 23193360 1225604 Positive_regulation PLG PLAT 23193360 1225605 Positive_regulation PLG PLAT 23193360 1225606 Positive_regulation PLG PLAT 23193360 1225607 Positive_regulation PLG PLAT 23193360 1225612 Positive_regulation PLG PLAT 23193360 1225613 Positive_regulation PLG PLAT 23226724 842792 Positive_regulation PLG PLAT 23279194 1692180 Positive_regulation PLG PLAT 23279194 1692181 Positive_regulation PLG PLAT 23279194 1692182 Positive_regulation PLG PLAT 23279194 1692183 Positive_regulation PLG PLAT 23363549 3178103 Positive_regulation PLG PLAT 23423137 3189926 Positive_regulation PLG PLAT 23515334 1137617 Positive_regulation PLG PLAT 23519104 1103118 Positive_regulation PLG PLAT 23519104 1103126 Positive_regulation PLG PLAT 23594879 2210319 Positive_regulation PLG PLAT 23773607 1243725 Positive_regulation PLG PLAT 23853591 3062993 Positive_regulation PLG PLAT 23874812 2822924 Positive_regulation PLG PLAT 23919120 141968 Positive_regulation PLG PLAT 24094605 3178119 Positive_regulation PLG PLAT 24094605 3178122 Positive_regulation PLG PLAT 24205133 2875491 Positive_regulation PLG PLAT 24215724 538346 Positive_regulation PLG PLAT 24286332 222304 Positive_regulation PLG PLAT 24373348 854646 Positive_regulation PLG PLAT 24383758 157147 Positive_regulation PLG PLAT 24557578 1123944 Positive_regulation PLG PLAT 24587197 2929039 Positive_regulation PLG PLAT 24647546 2936280 Positive_regulation PLG PLAT 24647546 2936281 Positive_regulation PLG PLAT 24647546 2936283 Positive_regulation PLG PLAT 24647546 2936284 Positive_regulation PLG PLAT 24647546 2936287 Positive_regulation PLG PLAT 24647546 2936289 Positive_regulation PLG PLAT 24772392 865107 Positive_regulation PLG PLAT 24959362 515489 Positive_regulation PLG PLAT 25054114 1022616 Positive_regulation PLG PLAT 2509486 1422849 Positive_regulation PLG PLAT 25166960 133023 Positive_regulation PLG PLAT 25386407 142099 Positive_regulation PLG PLAT 25632392 202540 Positive_regulation PLG PLAT 3031083 1425166 Positive_regulation PLG PLAT 3095333 1425737 Positive_regulation PLG PLAT 3204123 1426022 Positive_regulation PLG PLAT 8245131 1446293 Positive_regulation PLG PLAT 8394731 444893 Positive_regulation PLG PLAT 9635833 447091 Positive_regulation PLG PLAT 9744504 447915 Positive_regulation PLG PLAU 10098758 414096 Positive_regulation PLG PLAU 10408691 414757 Positive_regulation PLG PLAU 10917542 417308 Positive_regulation PLG PLAU 11044361 417981 Positive_regulation PLG PLAU 11219386 98342 Positive_regulation PLG PLAU 11266468 1269208 Positive_regulation PLG PLAU 11266468 1269212 Positive_regulation PLG PLAU 11560996 1520950 Positive_regulation PLG PLAU 12499359 1290499 Positive_regulation PLG PLAU 12615902 1526076 Positive_regulation PLG PLAU 12615902 1526079 Positive_regulation PLG PLAU 12617738 658453 Positive_regulation PLG PLAU 1380001 1298358 Positive_regulation PLG PLAU 16277677 104620 Positive_regulation PLG PLAU 1661735 1328988 Positive_regulation PLG PLAU 16646560 1711385 Positive_regulation PLG PLAU 16646560 1711390 Positive_regulation PLG PLAU 17134505 312967 Positive_regulation PLG PLAU 17134505 312968 Positive_regulation PLG PLAU 17134505 312975 Positive_regulation PLG PLAU 17134505 312976 Positive_regulation PLG PLAU 17134505 312977 Positive_regulation PLG PLAU 17286208 1639514 Positive_regulation PLG PLAU 17576803 1341628 Positive_regulation PLG PLAU 19008962 2400773 Positive_regulation PLG PLAU 19008962 2400779 Positive_regulation PLG PLAU 19008962 2400780 Positive_regulation PLG PLAU 1918136 1363669 Positive_regulation PLG PLAU 19638192 374406 Positive_regulation PLG PLAU 19703758 1703362 Positive_regulation PLG PLAU 19706694 811441 Positive_regulation PLG PLAU 19845941 1852145 Positive_regulation PLG PLAU 19845941 1852146 Positive_regulation PLG PLAU 19845941 1852148 Positive_regulation PLG PLAU 19845941 1852149 Positive_regulation PLG PLAU 19845941 1852165 Positive_regulation PLG PLAU 19893210 736371 Positive_regulation PLG PLAU 20856796 2474684 Positive_regulation PLG PLAU 21464960 2510701 Positive_regulation PLG PLAU 21837240 1066615 Positive_regulation PLG PLAU 21931850 2555048 Positive_regulation PLG PLAU 22087329 2571460 Positive_regulation PLG PLAU 22454771 154747 Positive_regulation PLG PLAU 22621373 471550 Positive_regulation PLG PLAU 22701432 958012 Positive_regulation PLG PLAU 22754528 951916 Positive_regulation PLG PLAU 22754528 951920 Positive_regulation PLG PLAU 22754528 951922 Positive_regulation PLG PLAU 22792020 686362 Positive_regulation PLG PLAU 22919385 1674163 Positive_regulation PLG PLAU 22927998 2681286 Positive_regulation PLG PLAU 23049759 2699442 Positive_regulation PLG PLAU 23118495 1225261 Positive_regulation PLG PLAU 23118506 1225351 Positive_regulation PLG PLAU 23118509 1225489 Positive_regulation PLG PLAU 23118509 1225490 Positive_regulation PLG PLAU 23118509 1225491 Positive_regulation PLG PLAU 23118518 1225535 Positive_regulation PLG PLAU 23125522 1225548 Positive_regulation PLG PLAU 23125522 1225555 Positive_regulation PLG PLAU 23125524 1225578 Positive_regulation PLG PLAU 23125524 1225584 Positive_regulation PLG PLAU 23125524 1225585 Positive_regulation PLG PLAU 23236466 2726473 Positive_regulation PLG PLAU 23410038 151305 Positive_regulation PLG PLAU 23536772 2771495 Positive_regulation PLG PLAU 23675430 2792871 Positive_regulation PLG PLAU 23758884 1868672 Positive_regulation PLG PLAU 23806081 3113681 Positive_regulation PLG PLAU 23853591 3062987 Positive_regulation PLG PLAU 23853591 3062988 Positive_regulation PLG PLAU 23853591 3062989 Positive_regulation PLG PLAU 23853591 3062990 Positive_regulation PLG PLAU 23853591 3062996 Positive_regulation PLG PLAU 23874773 2822483 Positive_regulation PLG PLAU 23874812 2822925 Positive_regulation PLG PLAU 23898467 864155 Positive_regulation PLG PLAU 23984088 1150894 Positive_regulation PLG PLAU 23984088 1150914 Positive_regulation PLG PLAU 23984088 1150972 Positive_regulation PLG PLAU 23984088 1150983 Positive_regulation PLG PLAU 24052804 3177348 Positive_regulation PLG PLAU 24129242 442096 Positive_regulation PLG PLAU 24194929 2872725 Positive_regulation PLG PLAU 24279676 856804 Positive_regulation PLG PLAU 24348274 2354254 Positive_regulation PLG PLAU 24383758 157148 Positive_regulation PLG PLAU 24465541 2910708 Positive_regulation PLG PLAU 24681666 2188615 Positive_regulation PLG PLAU 24681666 2188616 Positive_regulation PLG PLAU 24772392 865108 Positive_regulation PLG PLAU 25222667 1730982 Positive_regulation PLG PLAU 25538763 2007526 Positive_regulation PLG PLAU 2848851 1424317 Positive_regulation PLG PLAU 3730252 443539 Positive_regulation PLG PLAU 3746200 1583648 Positive_regulation PLG PLAU 7721938 1439631 Positive_regulation PLG PLAU 7721938 1439637 Positive_regulation PLG PLAU 8522616 1449790 Positive_regulation PLG PLAU 9020484 445972 Positive_regulation PLG PLAU 9083329 446136 Positive_regulation PLG PLAU 9472634 446862 Positive_regulation PLG PLAU 9566979 1467639 Positive_regulation PLG PLAU 9635833 447099 Positive_regulation PLG PLAU 9635833 447102 Positive_regulation PLG PLAU 9662256 447326 Positive_regulation PLG PLAU 9744504 447916 Positive_regulation PLG TNF 15559369 630335 Positive_regulation PLG TNF 1714936 1543586 Positive_regulation PLIN1 PGC 25610428 881540 Positive_regulation PLIN1 TNF 23499576 3204082 Positive_regulation PLIN1 TNF 24475180 2915168 Positive_regulation PLIN2 TLR7 24718259 2950521 Positive_regulation PLK1 F2R 23926048 2212049 Positive_regulation PLK1 FOXO1 19384426 668847 Positive_regulation PLK1 NES 15251038 277810 Positive_regulation PLK1 TLR7 24205328 2876048 Positive_regulation PLK1 TNF 20484576 1776876 Positive_regulation PLK4 NES 15251038 277759 Positive_regulation PLN TNF 19956717 2432599 Positive_regulation PLN TNFSF10 22672528 482510 Positive_regulation PLSCR4 FOXO1 25369332 3022705 Positive_regulation PLXNA4 TLR7 21098092 1561919 Positive_regulation PLXNB1 TMEM100 25137062 3000136 Positive_regulation PLXNB1 TMEM156 25137062 3000154 Positive_regulation PLXNB1 TMEM211 25137062 3000234 Positive_regulation PLXNB1 TMEM213 25137062 3000171 Positive_regulation PMPCA IFI27 21762531 357046 Positive_regulation PMPCB TNF 20967264 2478610 Positive_regulation PMPCB TNF 22880094 2674199 Positive_regulation PODXL EBF1 24172684 1709571 Positive_regulation PODXL FLI1 18648544 2393804 Positive_regulation PODXL FOXC1 25485314 579624 Positive_regulation PODXL GAPDH 25460740 3094844 Positive_regulation PODXL KCNH2 18648544 2393805 Positive_regulation PODXL SLC9A3R1 17311105 2374667 Positive_regulation PODXL SLC9A3R1 17311105 2374668 Positive_regulation PODXL SP1 23560927 294333 Positive_regulation PODXL WT1 19050011 2039100 Positive_regulation PODXL WT1 19050011 2039104 Positive_regulation PODXL WT1 19050011 2039114 Positive_regulation PODXL WT1 21390327 2506430 Positive_regulation PODXL WT1 21390327 2506436 Positive_regulation PODXL WT1 21390327 2506440 Positive_regulation PODXL WT1 21390327 2506443 Positive_regulation PODXL WT1 24327929 2234765 Positive_regulation PODXL WT1 24619359 1034751 Positive_regulation PODXL WT1 25485314 579623 Positive_regulation POLD3 TLR7 19430534 2416250 Positive_regulation POLDIP2 EPHB2 22294469 135315 Positive_regulation POLDIP2 F2R 21029417 354125 Positive_regulation POLDIP2 F2R 21760880 2535625 Positive_regulation POLDIP2 FAS 14970175 1531116 Positive_regulation POLDIP2 FBXO32 22082477 682622 Positive_regulation POLDIP2 ID1 18489764 352168 Positive_regulation POLDIP2 IL1B 18553155 3090115 Positive_regulation POLDIP2 MAP2K6 21109534 2059073 Positive_regulation POLDIP2 MAP2K6 21345249 121603 Positive_regulation POLDIP2 MAP2K6 22069624 3182809 Positive_regulation POLDIP2 MAP2K6 24611016 2122782 Positive_regulation POLDIP2 MAP2K6 24855454 1627911 Positive_regulation POLDIP2 MAP2K6 9314533 1463468 Positive_regulation POLDIP2 PTGER2 25327961 216569 Positive_regulation POLDIP2 S100B 23259641 1665759 Positive_regulation POLDIP2 STAT4 11094415 98079 Positive_regulation POLDIP2 TNF 16207331 104266 Positive_regulation POLDIP2 TNF 19389260 525270 Positive_regulation POLDIP2 TNF 21345249 121577 Positive_regulation POLDIP2 TNF 21572963 2520293 Positive_regulation POLDIP2 TNF 21738708 2533441 Positive_regulation POLDIP2 TNF 22069639 3182964 Positive_regulation POLDIP2 TNF 22837815 3131082 Positive_regulation POLDIP2 TNF 24069158 2851533 Positive_regulation POLDIP2 TNF 24307884 3155521 Positive_regulation POLDIP2 TNF 24423080 538867 Positive_regulation POLDIP2 TNF 24446489 1574664 Positive_regulation POLDIP2 TNF 24982891 193536 Positive_regulation POLDIP2 TNFSF10 22462553 1230485 Positive_regulation POLR2A PGC 17389765 3071455 Positive_regulation POLR2A TNF 21298084 2321003 Positive_regulation POLR2A TNF 22761878 2659073 Positive_regulation POLR2B PGC 17389765 3071456 Positive_regulation POLR2B TNF 21298084 2321004 Positive_regulation POLR2C PGC 17389765 3071457 Positive_regulation POLR2C TNF 21298084 2321005 Positive_regulation POLR2D PGC 17389765 3071458 Positive_regulation POLR2D TNF 21298084 2321006 Positive_regulation POLR2E PGC 17389765 3071459 Positive_regulation POLR2E TNF 21298084 2321007 Positive_regulation POLR2F PGC 17389765 3071460 Positive_regulation POLR2F TNF 21298084 2321008 Positive_regulation POLR2G PGC 17389765 3071461 Positive_regulation POLR2G TNF 21298084 2321009 Positive_regulation POLR2H PGC 17389765 3071462 Positive_regulation POLR2H TNF 21298084 2321010 Positive_regulation POLR2I PGC 17389765 3071463 Positive_regulation POLR2I TNF 21298084 2321011 Positive_regulation POLR2J PGC 17389765 3071464 Positive_regulation POLR2J TNF 21298084 2321012 Positive_regulation POLR2K PGC 17389765 3071465 Positive_regulation POLR2K TNF 21298084 2321013 Positive_regulation POLR2L PGC 17389765 3071466 Positive_regulation POLR2L TNF 21298084 2321014 Positive_regulation POMC EPHB2 19066310 707401 Positive_regulation POMC FOXO1 20020036 2434509 Positive_regulation POMC IRS4 24567904 1887804 Positive_regulation PON1 EPHB2 24722398 3066681 Positive_regulation PON2 CAPN8 22666600 1639310 Positive_regulation POT1 PECAM1 10725328 1256529 Positive_regulation POT1 TNF 23342266 491908 Positive_regulation POU2F1 CCND1 24913037 273786 Positive_regulation POU2F1 EPHB2 24717932 1023944 Positive_regulation POU2F3 EPHB2 25178105 1632658 Positive_regulation POU5F1 EPHB2 24643025 2935533 Positive_regulation POU5F1 EPHB2 24643025 2935561 Positive_regulation POU5F1 NES 23874697 2822074 Positive_regulation POU5F1 NR2F1 23451132 2758130 Positive_regulation POU5F1 TNF 24580841 3169889 Positive_regulation POU5F1 ZFP57 24550733 2356283 Positive_regulation POU5F1 ZFP57 24550733 2356429 Positive_regulation POU5F1 ZFP57 24550733 2356649 Positive_regulation PPA1 AXIN2 21814488 2276968 Positive_regulation PPA2 AXIN2 21814488 2276962 Positive_regulation PPARA ARSA 15824083 1535472 Positive_regulation PPARA ARSA 15824083 1535500 Positive_regulation PPARA ARSA 15824083 1535504 Positive_regulation PPARA ARSA 15824083 1535505 Positive_regulation PPARA EFNB1 18618001 2305589 Positive_regulation PPARA EPHB2 19609453 3074961 Positive_regulation PPARA EPHB2 24240026 2185333 Positive_regulation PPARA FAS 23193424 816280 Positive_regulation PPARA FOXO1 17531095 2013467 Positive_regulation PPARA MAP2K6 24240026 2185339 Positive_regulation PPARA PGC 23497303 3113549 Positive_regulation PPARA PGC 23951275 2834102 Positive_regulation PPARA PGC 25295003 860020 Positive_regulation PPARA TNF 18315837 1670758 Positive_regulation PPARA TNF 23251142 3076085 Positive_regulation PPARA WNT7A 24204697 2873494 Positive_regulation PPARD PGC 25295003 860021 Positive_regulation PPARG FOXO1 22815850 2666428 Positive_regulation PPBP CXCR2 23136963 412329 Positive_regulation PPBP IL1A 23136963 412327 Positive_regulation PPBP IL6 23136963 412317 Positive_regulation PPBP IL6 23136963 412318 Positive_regulation PPBP MAPK3 20652010 1672289 Positive_regulation PPBP PPBPP1 23798728 1405614 Positive_regulation PPBP PPBPP1 23798728 1405615 Positive_regulation PPBP ZC3H10 24470144 2098042 Positive_regulation PPBP ZC3H13 24470144 2098038 Positive_regulation PPBP ZC3H14 24470144 2098039 Positive_regulation PPBP ZC3H15 24470144 2098044 Positive_regulation PPBP ZC3H18 24470144 2098041 Positive_regulation PPBP ZC3H3 24470144 2098043 Positive_regulation PPBP ZC3H4 24470144 2098037 Positive_regulation PPBP ZC3H6 24470144 2098040 Positive_regulation PPBP ZC3H8 24470144 2098045 Positive_regulation PPBPP1 PPBP 25288925 2254568 Positive_regulation PPM1B TNF 23472066 2763776 Positive_regulation PPP1R13B TP63 18676979 2035570 Positive_regulation PPP1R15A TNFSF10 24525736 572126 Positive_regulation PPP2CA CCND1 19416500 1994729 Positive_regulation PPP2CA CCND1 19416500 1994730 Positive_regulation PPP2CA EPHB2 23704935 2796678 Positive_regulation PPP2CA FOXO1 23950968 2833062 Positive_regulation PPP2CA INPP4B 22895072 478803 Positive_regulation PPP2CA MUC16 22131998 1703156 Positive_regulation PPP2CA TNF 23549267 1104967 Positive_regulation PPP2R1A EPHB2 23704935 2796680 Positive_regulation PPP2R1A FOXO1 23950968 2833063 Positive_regulation PPP2R1A INPP4B 22895072 478804 Positive_regulation PPP2R1A MUC16 22131998 1703172 Positive_regulation PPP2R1A NES 15251038 277811 Positive_regulation PPP2R1A TNF 23549267 1104968 Positive_regulation PPP2R2B EPHB2 23704935 2796682 Positive_regulation PPP2R2B FOXO1 23950968 2833064 Positive_regulation PPP2R2B INPP4B 22895072 478805 Positive_regulation PPP2R2B MUC16 22131998 1703188 Positive_regulation PPP2R2B TNF 23549267 1104969 Positive_regulation PPP3CA CAPN8 23233785 1915312 Positive_regulation PPP3CA CAPN8 24987545 86068 Positive_regulation PPP3CA CAPN8 24987545 86098 Positive_regulation PPP3CA CCL17 20174570 2313077 Positive_regulation PPP3CA EPHB2 14624253 2255192 Positive_regulation PPP3CA RCAN1 19124655 1553361 Positive_regulation PPP3CA RCAN1 19725972 1646653 Positive_regulation PPP3CA RCAN1 23118980 2712397 Positive_regulation PPP3CA RCAN1 23118980 2712416 Positive_regulation PPP3CA RCAN1 23497671 1884465 Positive_regulation PPP3CA RCAN1 25429622 579501 Positive_regulation PPP3CA TNF 21298033 2499363 Positive_regulation PPP3CA TNF 21298033 2499367 Positive_regulation PPP3CA TNF 24883060 1074242 Positive_regulation PPP3CA TNF 8046352 1593854 Positive_regulation PPP3CA TNF 8046352 1593869 Positive_regulation PPP3CB RCAN1 19725972 1646654 Positive_regulation PPP3CB RCAN1 23118980 2712398 Positive_regulation PPP3CB RCAN1 23118980 2712417 Positive_regulation PPP3CB TNF 21298033 2499364 Positive_regulation PPP3CB TNF 21298033 2499368 Positive_regulation PPP3CB TNF 8046352 1593870 Positive_regulation PPP3CC RCAN1 19725972 1646655 Positive_regulation PPP3CC RCAN1 23118980 2712399 Positive_regulation PPP3CC RCAN1 23118980 2712418 Positive_regulation PPP3CC TNF 21298033 2499365 Positive_regulation PPP3CC TNF 21298033 2499369 Positive_regulation PPP3CC TNF 8046352 1593871 Positive_regulation PPP3R1 CAPN8 23233785 1915326 Positive_regulation PPP3R1 CAPN8 24987545 86082 Positive_regulation PPP3R1 CAPN8 24987545 86113 Positive_regulation PPP3R1 EPHB2 14624253 2255193 Positive_regulation PPP3R1 RCAN1 19124655 1553362 Positive_regulation PPP3R1 RCAN1 22848844 2002930 Positive_regulation PPP3R1 RCAN1 23497671 1884466 Positive_regulation PPP3R1 RCAN1 25429622 579502 Positive_regulation PPP3R1 TNF 24883060 1074244 Positive_regulation PPP3R1 TNF 8046352 1593855 Positive_regulation PPRC1 PGC 22960139 1881379 Positive_regulation PPT1 FOXO1 19936085 981463 Positive_regulation PPT1 FOXO1 19936085 981482 Positive_regulation PRB1 HBEGF 23029355 2696798 Positive_regulation PRB2 HBEGF 23029355 2696800 Positive_regulation PRB3 HBEGF 23029355 2696802 Positive_regulation PRB4 HBEGF 23029355 2696804 Positive_regulation PRDM1 TLR7 21991317 2561374 Positive_regulation PRDM1 TNF 22249448 1566856 Positive_regulation PRDM16 HES2 19050759 2401632 Positive_regulation PRDM16 PGC 23990359 728503 Positive_regulation PRDM2 TNF 24832654 177049 Positive_regulation PRDM2 TNF 24832654 177052 Positive_regulation PRDX1 MMP7 24519465 2243687 Positive_regulation PRDX2 CCND1 16503970 1845084 Positive_regulation PRDX2 CCND1 16503970 1845089 Positive_regulation PRDX2 CCND1 16503970 1845090 Positive_regulation PRDX2 CCND1 16503970 1845091 Positive_regulation PRDX2 CCND1 16503970 1845095 Positive_regulation PRDX2 CCND1 16504004 1845114 Positive_regulation PRDX2 CCND1 16504004 1845115 Positive_regulation PRDX2 CCND1 16504004 1845116 Positive_regulation PRDX2 CCND1 16504004 1845131 Positive_regulation PRDX2 CCND1 16504004 1845172 Positive_regulation PRDX2 CCND1 16504004 1845185 Positive_regulation PRDX2 CCND1 16504004 1845192 Positive_regulation PRDX2 CCND1 16504004 1845193 Positive_regulation PRDX2 CCND1 16504004 1845197 Positive_regulation PRDX2 CCND1 16504004 1845202 Positive_regulation PRDX2 CCND1 20609221 1856766 Positive_regulation PRDX2 CST6 19503093 2125531 Positive_regulation PRDX2 DAPK1 20048748 8913 Positive_regulation PRDX2 DAPK1 20048748 8928 Positive_regulation PRDX2 IFI27 17999998 2031394 Positive_regulation PRDX2 IFI27 24157878 568607 Positive_regulation PRDX2 MMP7 24519465 2243688 Positive_regulation PRDX2 OXTR 23727821 1968005 Positive_regulation PRDX2 PLAU 20609221 1856767 Positive_regulation PRDX2 TNFSF10 25593641 206969 Positive_regulation PRDX2 TNFSF10 25593641 206974 Positive_regulation PRDX3 FOXO1 23801966 961526 Positive_regulation PRDX3 MMP7 24519465 2243689 Positive_regulation PRF1 ITGAL 23029299 2696075 Positive_regulation PRG2 ADAMTS1 25003544 454081 Positive_regulation PRG2 CTGF 20205862 397083 Positive_regulation PRG2 CTGF 23555635 2774668 Positive_regulation PRG2 CTGF 23555635 2774674 Positive_regulation PRG2 CTGF 24165687 129851 Positive_regulation PRG2 F2R 24279676 856812 Positive_regulation PRG2 MMP28 20021645 397011 Positive_regulation PRG2 MMP28 7629505 1591061 Positive_regulation PRG2 MMP28 7629505 1591127 Positive_regulation PRG2 MMP7 20021645 397026 Positive_regulation PRG2 MMP7 7629505 1591076 Positive_regulation PRG2 MMP7 7629505 1591142 Positive_regulation PRG2 TNF 14979937 100131 Positive_regulation PRG2 TNF 21955617 124054 Positive_regulation PRG2 TNF 21955617 124062 Positive_regulation PRG3 ADAMTS1 25003544 454084 Positive_regulation PRG3 CTGF 20205862 397084 Positive_regulation PRG3 CTGF 23555635 2774669 Positive_regulation PRG3 CTGF 23555635 2774675 Positive_regulation PRG3 CTGF 24165687 129852 Positive_regulation PRG3 F2R 24279676 856813 Positive_regulation PRG3 MMP28 20021645 397033 Positive_regulation PRG3 MMP28 7629505 1591083 Positive_regulation PRG3 MMP28 7629505 1591149 Positive_regulation PRG3 MMP7 20021645 397048 Positive_regulation PRG3 MMP7 7629505 1591098 Positive_regulation PRG3 MMP7 7629505 1591164 Positive_regulation PRG3 TNF 14979937 100132 Positive_regulation PRG3 TNF 21955617 124056 Positive_regulation PRG3 TNF 21955617 124064 Positive_regulation PRG4 ADAMTS1 25003544 454087 Positive_regulation PRG4 CTGF 20205862 397085 Positive_regulation PRG4 CTGF 23555635 2774670 Positive_regulation PRG4 CTGF 23555635 2774676 Positive_regulation PRG4 CTGF 24165687 129853 Positive_regulation PRG4 F2R 24279676 856814 Positive_regulation PRG4 MMP28 20021645 397055 Positive_regulation PRG4 MMP28 7629505 1591105 Positive_regulation PRG4 MMP28 7629505 1591171 Positive_regulation PRG4 MMP7 20021645 397070 Positive_regulation PRG4 MMP7 7629505 1591120 Positive_regulation PRG4 MMP7 7629505 1591186 Positive_regulation PRG4 TNF 14979937 100133 Positive_regulation PRG4 TNF 21955617 124058 Positive_regulation PRG4 TNF 21955617 124066 Positive_regulation PRIM2 TNF 7519620 1436170 Positive_regulation PRKAA1 CAPN8 25147502 870890 Positive_regulation PRKAA1 EPHB2 20231899 2443218 Positive_regulation PRKAA1 EPHB2 24710474 618091 Positive_regulation PRKAA1 FBXO32 24811453 2962847 Positive_regulation PRKAA1 FOXO1 21483870 2512501 Positive_regulation PRKAA1 FOXO1 22870349 696278 Positive_regulation PRKAA1 FOXO1 23248639 883250 Positive_regulation PRKAA1 GLP1R 22950055 730418 Positive_regulation PRKAA1 IFI27 22272173 3152496 Positive_regulation PRKAA1 MAP2K6 24643070 2935694 Positive_regulation PRKAA1 PGC 18974883 2399734 Positive_regulation PRKAA1 PGC 22829833 1068734 Positive_regulation PRKAA1 PGC 22919323 3153789 Positive_regulation PRKAA1 PGC 23434656 1101847 Positive_regulation PRKAA1 PGC 23874150 2283733 Positive_regulation PRKAA1 PGC 24070020 1869757 Positive_regulation PRKAA1 PGC 24455726 186392 Positive_regulation PRKAA1 PGC 24801481 2961404 Positive_regulation PRKAA1 PGC 25002755 1760048 Positive_regulation PRKAA1 STK39 22018140 244504 Positive_regulation PRKAA1 STK39 23024792 2689963 Positive_regulation PRKAA1 TNF 20808811 2472478 Positive_regulation PRKAA1 TNF 20808811 2472491 Positive_regulation PRKAA1 TNF 21673972 2528134 Positive_regulation PRKAA1 TNF 24669186 742934 Positive_regulation PRKAA2 CAPN8 25147502 870904 Positive_regulation PRKAA2 EPHB2 20231899 2443219 Positive_regulation PRKAA2 EPHB2 24710474 618092 Positive_regulation PRKAA2 FBXO32 24811453 2962849 Positive_regulation PRKAA2 FOXO1 21483870 2512503 Positive_regulation PRKAA2 FOXO1 22870349 696283 Positive_regulation PRKAA2 FOXO1 23248639 883259 Positive_regulation PRKAA2 GLP1R 22950055 730420 Positive_regulation PRKAA2 IFI27 22272173 3152497 Positive_regulation PRKAA2 MAP2K6 24643070 2935701 Positive_regulation PRKAA2 PGC 18974883 2399735 Positive_regulation PRKAA2 PGC 22829833 1068735 Positive_regulation PRKAA2 PGC 22919323 3153790 Positive_regulation PRKAA2 PGC 23434656 1101848 Positive_regulation PRKAA2 PGC 23874150 2283734 Positive_regulation PRKAA2 PGC 24070020 1869758 Positive_regulation PRKAA2 PGC 24455726 186393 Positive_regulation PRKAA2 PGC 24801481 2961405 Positive_regulation PRKAA2 PGC 25002755 1760049 Positive_regulation PRKAA2 STK39 22018140 244519 Positive_regulation PRKAA2 STK39 23024792 2689978 Positive_regulation PRKAA2 TNF 20808811 2472479 Positive_regulation PRKAA2 TNF 20808811 2472492 Positive_regulation PRKAA2 TNF 21673972 2528136 Positive_regulation PRKAA2 TNF 24669186 742935 Positive_regulation PRKAB1 CAPN8 25147502 870918 Positive_regulation PRKAB1 EPHB2 20231899 2443220 Positive_regulation PRKAB1 EPHB2 24710474 618093 Positive_regulation PRKAB1 FBXO32 24811453 2962851 Positive_regulation PRKAB1 FOXO1 21483870 2512505 Positive_regulation PRKAB1 FOXO1 22870349 696288 Positive_regulation PRKAB1 FOXO1 23248639 883268 Positive_regulation PRKAB1 GLP1R 22950055 730422 Positive_regulation PRKAB1 IFI27 22272173 3152498 Positive_regulation PRKAB1 MAP2K6 24643070 2935708 Positive_regulation PRKAB1 PGC 18974883 2399736 Positive_regulation PRKAB1 PGC 22829833 1068736 Positive_regulation PRKAB1 PGC 22919323 3153791 Positive_regulation PRKAB1 PGC 23434656 1101849 Positive_regulation PRKAB1 PGC 23874150 2283735 Positive_regulation PRKAB1 PGC 24070020 1869759 Positive_regulation PRKAB1 PGC 24455726 186394 Positive_regulation PRKAB1 PGC 24801481 2961406 Positive_regulation PRKAB1 PGC 25002755 1760050 Positive_regulation PRKAB1 STK39 22018140 244534 Positive_regulation PRKAB1 STK39 23024792 2689993 Positive_regulation PRKAB1 TNF 20808811 2472480 Positive_regulation PRKAB1 TNF 20808811 2472493 Positive_regulation PRKAB1 TNF 21673972 2528138 Positive_regulation PRKAB1 TNF 24669186 742936 Positive_regulation PRKAB2 CAPN8 25147502 870932 Positive_regulation PRKAB2 EPHB2 20231899 2443221 Positive_regulation PRKAB2 EPHB2 24710474 618094 Positive_regulation PRKAB2 FBXO32 24811453 2962853 Positive_regulation PRKAB2 FOXO1 21483870 2512507 Positive_regulation PRKAB2 FOXO1 22870349 696293 Positive_regulation PRKAB2 FOXO1 23248639 883277 Positive_regulation PRKAB2 GLP1R 22950055 730424 Positive_regulation PRKAB2 IFI27 22272173 3152499 Positive_regulation PRKAB2 MAP2K6 24643070 2935715 Positive_regulation PRKAB2 PGC 18974883 2399737 Positive_regulation PRKAB2 PGC 22829833 1068737 Positive_regulation PRKAB2 PGC 22919323 3153792 Positive_regulation PRKAB2 PGC 23434656 1101850 Positive_regulation PRKAB2 PGC 23874150 2283736 Positive_regulation PRKAB2 PGC 24070020 1869760 Positive_regulation PRKAB2 PGC 24455726 186395 Positive_regulation PRKAB2 PGC 24801481 2961407 Positive_regulation PRKAB2 PGC 25002755 1760051 Positive_regulation PRKAB2 STK39 22018140 244549 Positive_regulation PRKAB2 STK39 23024792 2690008 Positive_regulation PRKAB2 TNF 20808811 2472481 Positive_regulation PRKAB2 TNF 20808811 2472494 Positive_regulation PRKAB2 TNF 21673972 2528140 Positive_regulation PRKAB2 TNF 24669186 742937 Positive_regulation PRKACA NES 15251038 277812 Positive_regulation PRKACB ALOX5 24991451 82492 Positive_regulation PRKACB EPHB2 21811393 1680230 Positive_regulation PRKACB EPHB2 22666628 2232492 Positive_regulation PRKACB EPHB2 22751695 723536 Positive_regulation PRKACB EPHB2 23034049 3113198 Positive_regulation PRKACB EPHB2 23056062 1156231 Positive_regulation PRKACB EPHB2 24278035 2353114 Positive_regulation PRKACB GLP1R 22577369 833044 Positive_regulation PRKACB GLP1R 22776039 731712 Positive_regulation PRKACB GLP1R 23578994 727053 Positive_regulation PRKACB GLP1R 23969997 839541 Positive_regulation PRKACB GLP1R 24244813 204860 Positive_regulation PRKACB GLP1R 24244813 204874 Positive_regulation PRKACB GLP1R 24244813 204893 Positive_regulation PRKACB GLP1R 24244813 204899 Positive_regulation PRKACB GLP1R 24843641 1494274 Positive_regulation PRKACB GPR115 22384111 2605257 Positive_regulation PRKACB GPR115 24238363 221401 Positive_regulation PRKACB GPR115 24672804 1495772 Positive_regulation PRKACB GPR132 22384111 2605246 Positive_regulation PRKACB GPR132 24238363 221390 Positive_regulation PRKACB GPR132 24672804 1495761 Positive_regulation PRKACB GPR87 22384111 2605326 Positive_regulation PRKACB GPR87 24238363 221470 Positive_regulation PRKACB GPR87 24672804 1495841 Positive_regulation PRKACB MAP2K6 19419557 1891309 Positive_regulation PRKACB MAP2K6 20802507 11739 Positive_regulation PRKACB MAP2K6 22022509 2563463 Positive_regulation PRKACB MUC16 24757369 1716424 Positive_regulation PRKACB PGC 23554809 3076475 Positive_regulation PRKACB PTGER2 19561612 1952577 Positive_regulation PRKACB PTGER2 23760108 907486 Positive_regulation PRKACB RASSF10 23552700 2156415 Positive_regulation PRKACB RASSF10 23552700 2156427 Positive_regulation PRKACB RCAN1 22848844 2002931 Positive_regulation PRKACB TNF 23071583 2703116 Positive_regulation PRKACB WNT7A 21902831 3160674 Positive_regulation PRKACG ALOX5 24991451 82493 Positive_regulation PRKACG EPHB2 21811393 1680231 Positive_regulation PRKACG EPHB2 22666628 2232493 Positive_regulation PRKACG EPHB2 22751695 723537 Positive_regulation PRKACG EPHB2 23034049 3113199 Positive_regulation PRKACG EPHB2 23056062 1156233 Positive_regulation PRKACG EPHB2 24278035 2353118 Positive_regulation PRKACG GLP1R 22577369 833045 Positive_regulation PRKACG GLP1R 22776039 731713 Positive_regulation PRKACG GLP1R 23578994 727055 Positive_regulation PRKACG GLP1R 23969997 839543 Positive_regulation PRKACG GLP1R 24244813 204861 Positive_regulation PRKACG GLP1R 24244813 204875 Positive_regulation PRKACG GLP1R 24244813 204894 Positive_regulation PRKACG GLP1R 24244813 204900 Positive_regulation PRKACG GLP1R 24843641 1494290 Positive_regulation PRKACG GPR115 22384111 2605350 Positive_regulation PRKACG GPR115 24238363 221494 Positive_regulation PRKACG GPR115 24672804 1495865 Positive_regulation PRKACG GPR132 22384111 2605339 Positive_regulation PRKACG GPR132 24238363 221483 Positive_regulation PRKACG GPR132 24672804 1495854 Positive_regulation PRKACG GPR87 22384111 2605419 Positive_regulation PRKACG GPR87 24238363 221563 Positive_regulation PRKACG GPR87 24672804 1495934 Positive_regulation PRKACG MAP2K6 19419557 1891316 Positive_regulation PRKACG MAP2K6 20802507 11746 Positive_regulation PRKACG MAP2K6 22022509 2563470 Positive_regulation PRKACG MUC16 24757369 1716439 Positive_regulation PRKACG PGC 23554809 3076489 Positive_regulation PRKACG PTGER2 19561612 1952578 Positive_regulation PRKACG PTGER2 23760108 907489 Positive_regulation PRKACG RASSF10 23552700 2156416 Positive_regulation PRKACG RASSF10 23552700 2156428 Positive_regulation PRKACG RCAN1 22848844 2002932 Positive_regulation PRKACG TNF 23071583 2703117 Positive_regulation PRKACG WNT7A 21902831 3160678 Positive_regulation PRKAG1 CAPN8 25147502 870946 Positive_regulation PRKAG1 EPHB2 20231899 2443222 Positive_regulation PRKAG1 EPHB2 24710474 618095 Positive_regulation PRKAG1 FBXO32 24811453 2962855 Positive_regulation PRKAG1 FOXO1 21483870 2512509 Positive_regulation PRKAG1 FOXO1 22870349 696298 Positive_regulation PRKAG1 FOXO1 23248639 883286 Positive_regulation PRKAG1 GLP1R 22950055 730426 Positive_regulation PRKAG1 IFI27 22272173 3152500 Positive_regulation PRKAG1 MAP2K6 24643070 2935722 Positive_regulation PRKAG1 PGC 18974883 2399738 Positive_regulation PRKAG1 PGC 22829833 1068738 Positive_regulation PRKAG1 PGC 22919323 3153793 Positive_regulation PRKAG1 PGC 23434656 1101851 Positive_regulation PRKAG1 PGC 23874150 2283737 Positive_regulation PRKAG1 PGC 24070020 1869761 Positive_regulation PRKAG1 PGC 24455726 186396 Positive_regulation PRKAG1 PGC 24801481 2961408 Positive_regulation PRKAG1 PGC 25002755 1760052 Positive_regulation PRKAG1 STK39 22018140 244564 Positive_regulation PRKAG1 STK39 23024792 2690023 Positive_regulation PRKAG1 TNF 20808811 2472482 Positive_regulation PRKAG1 TNF 20808811 2472495 Positive_regulation PRKAG1 TNF 21673972 2528142 Positive_regulation PRKAG1 TNF 24669186 742938 Positive_regulation PRKAG2 CAPN8 25147502 870960 Positive_regulation PRKAG2 EPHB2 20231899 2443223 Positive_regulation PRKAG2 EPHB2 24710474 618096 Positive_regulation PRKAG2 FBXO32 24811453 2962857 Positive_regulation PRKAG2 FOXO1 21483870 2512511 Positive_regulation PRKAG2 FOXO1 22870349 696303 Positive_regulation PRKAG2 FOXO1 23248639 883295 Positive_regulation PRKAG2 GLP1R 22950055 730428 Positive_regulation PRKAG2 IFI27 22272173 3152501 Positive_regulation PRKAG2 MAP2K6 24643070 2935729 Positive_regulation PRKAG2 PGC 18974883 2399739 Positive_regulation PRKAG2 PGC 22829833 1068739 Positive_regulation PRKAG2 PGC 22919323 3153794 Positive_regulation PRKAG2 PGC 23434656 1101852 Positive_regulation PRKAG2 PGC 23874150 2283738 Positive_regulation PRKAG2 PGC 24070020 1869762 Positive_regulation PRKAG2 PGC 24455726 186397 Positive_regulation PRKAG2 PGC 24801481 2961409 Positive_regulation PRKAG2 PGC 25002755 1760053 Positive_regulation PRKAG2 STK39 22018140 244579 Positive_regulation PRKAG2 STK39 23024792 2690038 Positive_regulation PRKAG2 TNF 20808811 2472483 Positive_regulation PRKAG2 TNF 20808811 2472496 Positive_regulation PRKAG2 TNF 21673972 2528144 Positive_regulation PRKAG2 TNF 24669186 742939 Positive_regulation PRKAR1A ALOX5 24991451 82494 Positive_regulation PRKAR1A EPHB2 21811393 1680232 Positive_regulation PRKAR1A EPHB2 22666628 2232494 Positive_regulation PRKAR1A EPHB2 22751695 723538 Positive_regulation PRKAR1A EPHB2 23034049 3113200 Positive_regulation PRKAR1A EPHB2 23056062 1156235 Positive_regulation PRKAR1A EPHB2 24278035 2353122 Positive_regulation PRKAR1A GLP1R 22577369 833046 Positive_regulation PRKAR1A GLP1R 22776039 731714 Positive_regulation PRKAR1A GLP1R 23578994 727057 Positive_regulation PRKAR1A GLP1R 23969997 839545 Positive_regulation PRKAR1A GLP1R 24244813 204862 Positive_regulation PRKAR1A GLP1R 24244813 204876 Positive_regulation PRKAR1A GLP1R 24244813 204895 Positive_regulation PRKAR1A GLP1R 24244813 204901 Positive_regulation PRKAR1A GLP1R 24843641 1494306 Positive_regulation PRKAR1A GPR115 22384111 2605443 Positive_regulation PRKAR1A GPR115 24238363 221587 Positive_regulation PRKAR1A GPR115 24672804 1495958 Positive_regulation PRKAR1A GPR132 22384111 2605432 Positive_regulation PRKAR1A GPR132 24238363 221576 Positive_regulation PRKAR1A GPR132 24672804 1495947 Positive_regulation PRKAR1A GPR87 22384111 2605512 Positive_regulation PRKAR1A GPR87 24238363 221656 Positive_regulation PRKAR1A GPR87 24672804 1496027 Positive_regulation PRKAR1A MAP2K6 19419557 1891323 Positive_regulation PRKAR1A MAP2K6 20802507 11753 Positive_regulation PRKAR1A MAP2K6 22022509 2563477 Positive_regulation PRKAR1A MUC16 24757369 1716454 Positive_regulation PRKAR1A PGC 23554809 3076503 Positive_regulation PRKAR1A PTGER2 19561612 1952579 Positive_regulation PRKAR1A PTGER2 23760108 907492 Positive_regulation PRKAR1A RASSF10 23552700 2156417 Positive_regulation PRKAR1A RASSF10 23552700 2156429 Positive_regulation PRKAR1A RCAN1 22848844 2002933 Positive_regulation PRKAR1A TNF 23071583 2703118 Positive_regulation PRKAR1A WNT7A 21902831 3160682 Positive_regulation PRKAR1B ALOX5 24991451 82495 Positive_regulation PRKAR1B EPHB2 21811393 1680233 Positive_regulation PRKAR1B EPHB2 22666628 2232495 Positive_regulation PRKAR1B EPHB2 22751695 723539 Positive_regulation PRKAR1B EPHB2 23034049 3113201 Positive_regulation PRKAR1B EPHB2 23056062 1156237 Positive_regulation PRKAR1B EPHB2 24278035 2353126 Positive_regulation PRKAR1B GLP1R 22577369 833047 Positive_regulation PRKAR1B GLP1R 22776039 731715 Positive_regulation PRKAR1B GLP1R 23578994 727059 Positive_regulation PRKAR1B GLP1R 23969997 839547 Positive_regulation PRKAR1B GLP1R 24244813 204863 Positive_regulation PRKAR1B GLP1R 24244813 204877 Positive_regulation PRKAR1B GLP1R 24244813 204896 Positive_regulation PRKAR1B GLP1R 24244813 204902 Positive_regulation PRKAR1B GLP1R 24843641 1494322 Positive_regulation PRKAR1B GPR115 22384111 2605536 Positive_regulation PRKAR1B GPR115 24238363 221680 Positive_regulation PRKAR1B GPR115 24672804 1496051 Positive_regulation PRKAR1B GPR132 22384111 2605525 Positive_regulation PRKAR1B GPR132 24238363 221669 Positive_regulation PRKAR1B GPR132 24672804 1496040 Positive_regulation PRKAR1B GPR87 22384111 2605605 Positive_regulation PRKAR1B GPR87 24238363 221749 Positive_regulation PRKAR1B GPR87 24672804 1496120 Positive_regulation PRKAR1B MAP2K6 19419557 1891330 Positive_regulation PRKAR1B MAP2K6 20802507 11760 Positive_regulation PRKAR1B MAP2K6 22022509 2563484 Positive_regulation PRKAR1B MUC16 24757369 1716469 Positive_regulation PRKAR1B PGC 23554809 3076517 Positive_regulation PRKAR1B PTGER2 19561612 1952580 Positive_regulation PRKAR1B PTGER2 23760108 907495 Positive_regulation PRKAR1B RASSF10 23552700 2156418 Positive_regulation PRKAR1B RASSF10 23552700 2156430 Positive_regulation PRKAR1B RCAN1 22848844 2002934 Positive_regulation PRKAR1B TNF 23071583 2703119 Positive_regulation PRKAR1B WNT7A 21902831 3160686 Positive_regulation PRKAR2A ALOX5 24991451 82496 Positive_regulation PRKAR2A EPHB2 21811393 1680234 Positive_regulation PRKAR2A EPHB2 22666628 2232496 Positive_regulation PRKAR2A EPHB2 22751695 723540 Positive_regulation PRKAR2A EPHB2 23034049 3113202 Positive_regulation PRKAR2A EPHB2 23056062 1156239 Positive_regulation PRKAR2A EPHB2 24278035 2353130 Positive_regulation PRKAR2A GLP1R 22577369 833048 Positive_regulation PRKAR2A GLP1R 22776039 731716 Positive_regulation PRKAR2A GLP1R 23578994 727061 Positive_regulation PRKAR2A GLP1R 23969997 839549 Positive_regulation PRKAR2A GLP1R 24244813 204864 Positive_regulation PRKAR2A GLP1R 24244813 204878 Positive_regulation PRKAR2A GLP1R 24244813 204897 Positive_regulation PRKAR2A GLP1R 24244813 204903 Positive_regulation PRKAR2A GLP1R 24843641 1494338 Positive_regulation PRKAR2A GPR115 22384111 2605629 Positive_regulation PRKAR2A GPR115 24238363 221773 Positive_regulation PRKAR2A GPR115 24672804 1496144 Positive_regulation PRKAR2A GPR132 22384111 2605618 Positive_regulation PRKAR2A GPR132 24238363 221762 Positive_regulation PRKAR2A GPR132 24672804 1496133 Positive_regulation PRKAR2A GPR87 22384111 2605698 Positive_regulation PRKAR2A GPR87 24238363 221842 Positive_regulation PRKAR2A GPR87 24672804 1496213 Positive_regulation PRKAR2A MAP2K6 19419557 1891337 Positive_regulation PRKAR2A MAP2K6 20802507 11767 Positive_regulation PRKAR2A MAP2K6 22022509 2563491 Positive_regulation PRKAR2A MUC16 24757369 1716484 Positive_regulation PRKAR2A PGC 23554809 3076531 Positive_regulation PRKAR2A PTGER2 19561612 1952581 Positive_regulation PRKAR2A PTGER2 23760108 907498 Positive_regulation PRKAR2A RASSF10 23552700 2156419 Positive_regulation PRKAR2A RASSF10 23552700 2156431 Positive_regulation PRKAR2A RCAN1 22848844 2002935 Positive_regulation PRKAR2A TNF 23071583 2703120 Positive_regulation PRKAR2A WNT7A 21902831 3160690 Positive_regulation PRKAR2B ALOX5 24991451 82497 Positive_regulation PRKAR2B EPHB2 21811393 1680235 Positive_regulation PRKAR2B EPHB2 22666628 2232497 Positive_regulation PRKAR2B EPHB2 22751695 723541 Positive_regulation PRKAR2B EPHB2 23034049 3113203 Positive_regulation PRKAR2B EPHB2 23056062 1156241 Positive_regulation PRKAR2B EPHB2 24278035 2353134 Positive_regulation PRKAR2B GLP1R 22577369 833049 Positive_regulation PRKAR2B GLP1R 22776039 731717 Positive_regulation PRKAR2B GLP1R 23578994 727063 Positive_regulation PRKAR2B GLP1R 23969997 839551 Positive_regulation PRKAR2B GLP1R 24244813 204865 Positive_regulation PRKAR2B GLP1R 24244813 204879 Positive_regulation PRKAR2B GLP1R 24244813 204898 Positive_regulation PRKAR2B GLP1R 24244813 204904 Positive_regulation PRKAR2B GLP1R 24843641 1494354 Positive_regulation PRKAR2B GPR115 22384111 2605722 Positive_regulation PRKAR2B GPR115 24238363 221866 Positive_regulation PRKAR2B GPR115 24672804 1496237 Positive_regulation PRKAR2B GPR132 22384111 2605711 Positive_regulation PRKAR2B GPR132 24238363 221855 Positive_regulation PRKAR2B GPR132 24672804 1496226 Positive_regulation PRKAR2B GPR87 22384111 2605791 Positive_regulation PRKAR2B GPR87 24238363 221935 Positive_regulation PRKAR2B GPR87 24672804 1496306 Positive_regulation PRKAR2B MAP2K6 19419557 1891344 Positive_regulation PRKAR2B MAP2K6 20802507 11774 Positive_regulation PRKAR2B MAP2K6 22022509 2563498 Positive_regulation PRKAR2B MUC16 24757369 1716499 Positive_regulation PRKAR2B NES 15251038 277813 Positive_regulation PRKAR2B PGC 23554809 3076545 Positive_regulation PRKAR2B PTGER2 19561612 1952582 Positive_regulation PRKAR2B PTGER2 23760108 907501 Positive_regulation PRKAR2B RASSF10 23552700 2156420 Positive_regulation PRKAR2B RASSF10 23552700 2156432 Positive_regulation PRKAR2B RCAN1 22848844 2002936 Positive_regulation PRKAR2B TNF 23071583 2703121 Positive_regulation PRKAR2B WNT7A 21902831 3160694 Positive_regulation PRKCB TNF 22792461 1139686 Positive_regulation PRKCDBP EPHB2 24069528 750738 Positive_regulation PRKDC TNFSF10 20205745 375348 Positive_regulation PRKDC TNFSF10 21513580 1861755 Positive_regulation PRKDC TNFSF10 21513580 1861756 Positive_regulation PRKDC TNFSF10 21513580 1861777 Positive_regulation PRL CCND1 16677418 459803 Positive_regulation PRL CCND1 22276155 2590213 Positive_regulation PRL CCND1 24913037 273788 Positive_regulation PRL EPHB2 22152284 1641015 Positive_regulation PRL FOXO1 23349855 2743546 Positive_regulation PRL HBEGF PMC4233545 477201 Positive_regulation PRL TNF 23731754 1627001 Positive_regulation PRL TNF 23956762 638362 Positive_regulation PRNP MAP2K6 25364742 862405 Positive_regulation PROC F2R 17480240 279747 Positive_regulation PROC F2R 24152910 220917 Positive_regulation PROC F2R 24215724 538226 Positive_regulation PROC F2R 24733067 1126058 Positive_regulation PROC F2R 24876677 1759038 Positive_regulation PROC F2R 25364818 3021835 Positive_regulation PROCR F2R 17893198 1547106 Positive_regulation PRODH ALDH18A1 25412179 3029050 Positive_regulation PRODH CHDH 20403182 393317 Positive_regulation PRODH CHDH 24410747 394815 Positive_regulation PRODH CHDH 24410747 394816 Positive_regulation PRODH CKAP4 23861960 2821062 Positive_regulation PRODH LMNA 24039956 2845127 Positive_regulation PRODH MIR23B 23164426 1699104 Positive_regulation PRODH MYC 22737668 940858 Positive_regulation PRODH MYLIP 22737668 940851 Positive_regulation PRODH PRKAA1 25474014 690676 Positive_regulation PRODH PRKAA2 25474014 690677 Positive_regulation PRODH PRKAB1 25474014 690678 Positive_regulation PRODH PRKAB2 25474014 690679 Positive_regulation PRODH PRKAG1 25474014 690680 Positive_regulation PRODH PRKAG2 25474014 690681 Positive_regulation PRODH PYCR1 24410747 394819 Positive_regulation PRODH TP53 17612399 233046 Positive_regulation PRODH TP53 17612399 233049 Positive_regulation PRODH TP53 17988400 233690 Positive_regulation PRODH TP53 23861960 2821060 Positive_regulation PRODH TP53 23861960 2821061 Positive_regulation PRODH TP53 23861960 2821072 Positive_regulation PRODH TP63 23861960 2821076 Positive_regulation PRODH USO1 23861960 2821070 Positive_regulation PRODH UVRAG 23861960 2821069 Positive_regulation PROK1 RCAN1 19348862 158312 Positive_regulation PROK1 RCAN1 19348862 158313 Positive_regulation PROK1 RCAN1 19348862 158351 Positive_regulation PROK1 RCAN1 19801577 1885314 Positive_regulation PROK1 TNFSF10 23531545 2086341 Positive_regulation PROM1 ABCG2 20027313 2435312 Positive_regulation PROM1 ANGPT1 22558265 2624896 Positive_regulation PROM1 EPHB2 20167130 1853558 Positive_regulation PROS1 KCNK3 25372054 1026074 Positive_regulation PROS1 TNF 2803928 443159 Positive_regulation PROX1 LIPG 21985497 305921 Positive_regulation PRPH TNF 11604419 1275712 Positive_regulation PRPS1 BPI 22783227 925158 Positive_regulation PRPS2 BPI 22783227 925159 Positive_regulation PRR11 TNF 19721713 2425592 Positive_regulation PRR12 TNF 19721713 2425604 Positive_regulation PRR13 TNF 19721713 2425590 Positive_regulation PRR14 TNF 19721713 2425600 Positive_regulation PRR15 TNF 19721713 2425588 Positive_regulation PRR16 TNF 19721713 2425606 Positive_regulation PRR18 TNF 19721713 2425602 Positive_regulation PRR19 TNF 19721713 2425614 Positive_regulation PRR21 TNF 19721713 2425616 Positive_regulation PRR22 TNF 19721713 2425598 Positive_regulation PRR24 TNF 19721713 2425594 Positive_regulation PRR25 TNF 19721713 2425618 Positive_regulation PRR26 TNF 19721713 2425608 Positive_regulation PRR3 TNF 19721713 2425586 Positive_regulation PRR4 TNF 19721713 2425584 Positive_regulation PRR5 FOXO1 23875175 945967 Positive_regulation PRR5 TNF 19721713 2425610 Positive_regulation PRR7 TNF 19721713 2425596 Positive_regulation PRR9 TNF 19721713 2425612 Positive_regulation PRS EDN2 23469133 2762018 Positive_regulation PRX NES 24633211 2934716 Positive_regulation PRX NES 24633211 2934722 Positive_regulation PRX NES 24633211 2934724 Positive_regulation PSEN1 IL1B 16410651 735942 Positive_regulation PSEN2 ARSA 14633288 392517 Positive_regulation PSG1 SRGN 22754550 925112 Positive_regulation PSG11 SRGN 22754550 925113 Positive_regulation PSG2 SRGN 22754550 925114 Positive_regulation PSG3 SRGN 22754550 925115 Positive_regulation PSG4 SRGN 22754550 925116 Positive_regulation PSG5 SRGN 22754550 925117 Positive_regulation PSG6 SRGN 22754550 925118 Positive_regulation PSG7 SRGN 22754550 925119 Positive_regulation PSG8 SRGN 22754550 925120 Positive_regulation PSG9 SRGN 22754550 925121 Positive_regulation PSIP1 FAS 22046349 2566529 Positive_regulation PSIP1 FAS 22046349 2566769 Positive_regulation PSMB9 EPHB2 19635566 3157441 Positive_regulation PSMB9 TNF 7699330 1591714 Positive_regulation PSMB9 TNF 7699330 1591715 Positive_regulation PSMB9 TP63 20498633 2132345 Positive_regulation PSMB9 TP63 20498633 2132346 Positive_regulation PSMD14 OSR1 21203417 2489925 Positive_regulation PSMD4 CAPN8 23580245 935354 Positive_regulation PSMD4 CAPN8 25628533 932380 Positive_regulation PSMG1 EPHB2 20093365 1169144 Positive_regulation PTAFR F2R 23448515 660408 Positive_regulation PTAFR F2R PMC2756345 496009 Positive_regulation PTBP1 CCL17 24701375 2163126 Positive_regulation PTBP1 EDN2 18195069 1548341 Positive_regulation PTBP1 EDN2 18195069 1548342 Positive_regulation PTBP1 EDN2 18195069 1548343 Positive_regulation PTBP1 EDN2 18195069 1548344 Positive_regulation PTBP1 EDN2 18195069 1548396 Positive_regulation PTBP1 EDN2 18195077 1548757 Positive_regulation PTBP1 EPHB2 20967853 135149 Positive_regulation PTBP1 EPHB2 20967853 135150 Positive_regulation PTBP1 EPHB2 20967853 135151 Positive_regulation PTBP1 EPHB2 20967853 135159 Positive_regulation PTBP1 EPHB2 20967853 135173 Positive_regulation PTBP1 EPHB2 20967853 135174 Positive_regulation PTBP1 EPHB2 20967853 135178 Positive_regulation PTBP1 EPHB2 23526794 3149824 Positive_regulation PTBP1 EPHB2 23526794 3149829 Positive_regulation PTBP1 EPHB2 25111504 2996235 Positive_regulation PTBP1 FAS 11104808 1518125 Positive_regulation PTBP1 ITGAL 23221473 3217411 Positive_regulation PTBP1 ITGB2 21980488 2560930 Positive_regulation PTBP1 ITGB2 22238634 2586759 Positive_regulation PTBP1 ITGB2 22238634 2586760 Positive_regulation PTBP1 ITGB2 22238634 2586761 Positive_regulation PTBP1 MAP2K6 21544193 2517141 Positive_regulation PTBP1 MIP 10562317 1513064 Positive_regulation PTBP1 NES 25545659 3036355 Positive_regulation PTBP1 PTGER2 24024207 183897 Positive_regulation PTBP1 TCN1 22750193 1492606 Positive_regulation PTBP1 TLR7 12045249 1523596 Positive_regulation PTBP1 TLR7 15492123 1533718 Positive_regulation PTBP1 TLR7 15795237 1535277 Positive_regulation PTBP1 TLR7 15851485 1535821 Positive_regulation PTBP1 TLR7 17296788 1544370 Positive_regulation PTBP1 TLR7 17296788 1544461 Positive_regulation PTBP1 TLR7 17535975 1546259 Positive_regulation PTBP1 TLR7 17535975 1546264 Positive_regulation PTBP1 TLR7 17535975 1546268 Positive_regulation PTBP1 TLR7 17954572 1547374 Positive_regulation PTBP1 TLR7 17954572 1547379 Positive_regulation PTBP1 TLR7 18086320 109673 Positive_regulation PTBP1 TLR7 18458113 1550719 Positive_regulation PTBP1 TLR7 18458113 1550720 Positive_regulation PTBP1 TLR7 18458113 1550721 Positive_regulation PTBP1 TLR7 18458113 1550778 Positive_regulation PTBP1 TLR7 18533024 352285 Positive_regulation PTBP1 TLR7 19204112 1553934 Positive_regulation PTBP1 TLR7 19204112 1554082 Positive_regulation PTBP1 TLR7 19259329 1146842 Positive_regulation PTBP1 TLR7 19294011 2214919 Positive_regulation PTBP1 TLR7 19476613 113390 Positive_regulation PTBP1 TLR7 19476613 113398 Positive_regulation PTBP1 TLR7 19557165 3044261 Positive_regulation PTBP1 TLR7 19635859 1555490 Positive_regulation PTBP1 TLR7 19667062 1555621 Positive_regulation PTBP1 TLR7 19703986 1555978 Positive_regulation PTBP1 TLR7 19808251 1556456 Positive_regulation PTBP1 TLR7 20021667 1696511 Positive_regulation PTBP1 TLR7 20021667 1696533 Positive_regulation PTBP1 TLR7 20021667 1696539 Positive_regulation PTBP1 TLR7 20308362 1557887 Positive_regulation PTBP1 TLR7 20379390 1214306 Positive_regulation PTBP1 TLR7 20379390 1214346 Positive_regulation PTBP1 TLR7 20379390 1214563 Positive_regulation PTBP1 TLR7 20379390 1214603 Positive_regulation PTBP1 TLR7 20379390 1214656 Positive_regulation PTBP1 TLR7 20533427 774768 Positive_regulation PTBP1 TLR7 20533427 774822 Positive_regulation PTBP1 TLR7 20617179 3047893 Positive_regulation PTBP1 TLR7 20808670 1635262 Positive_regulation PTBP1 TLR7 21059854 1561265 Positive_regulation PTBP1 TLR7 21059854 1561305 Positive_regulation PTBP1 TLR7 21059854 1561345 Positive_regulation PTBP1 TLR7 21059854 1561385 Positive_regulation PTBP1 TLR7 21555485 1563715 Positive_regulation PTBP1 TLR7 21706041 13011 Positive_regulation PTBP1 TLR7 21738472 3052197 Positive_regulation PTBP1 TLR7 21743479 1955600 Positive_regulation PTBP1 TLR7 22019834 1956009 Positive_regulation PTBP1 TLR7 22125457 3152186 Positive_regulation PTBP1 TLR7 22125457 3152284 Positive_regulation PTBP1 TLR7 22190970 633687 Positive_regulation PTBP1 TLR7 22193989 488256 Positive_regulation PTBP1 TLR7 22383883 3055789 Positive_regulation PTBP1 TLR7 22399974 3158754 Positive_regulation PTBP1 TLR7 22566954 900456 Positive_regulation PTBP1 TLR7 22737174 636475 Positive_regulation PTBP1 TLR7 22984435 2688591 Positive_regulation PTBP1 TLR7 23112799 904826 Positive_regulation PTBP1 TLR7 23162764 2161557 Positive_regulation PTBP1 TLR7 23202469 3221669 Positive_regulation PTBP1 TLR7 23202469 3221670 Positive_regulation PTBP1 TLR7 23202493 3221731 Positive_regulation PTBP1 TLR7 23221477 3217486 Positive_regulation PTBP1 TLR7 23223197 3221957 Positive_regulation PTBP1 TLR7 23227255 2725947 Positive_regulation PTBP1 TLR7 23300676 2734652 Positive_regulation PTBP1 TLR7 23484075 179357 Positive_regulation PTBP1 TLR7 23497717 128073 Positive_regulation PTBP1 TLR7 23557436 359155 Positive_regulation PTBP1 TLR7 23593527 2371855 Positive_regulation PTBP1 TLR7 23630623 2785383 Positive_regulation PTBP1 TLR7 23653115 1919898 Positive_regulation PTBP1 TLR7 23690937 2793861 Positive_regulation PTBP1 TLR7 23691339 1151758 Positive_regulation PTBP1 TLR7 23762810 2162458 Positive_regulation PTBP1 TLR7 23781253 637878 Positive_regulation PTBP1 TLR7 24020520 1869622 Positive_regulation PTBP1 TLR7 24204367 909783 Positive_regulation PTBP1 TLR7 24228229 2162715 Positive_regulation PTBP1 TLR7 24335833 1736553 Positive_regulation PTBP1 TLR7 24482744 2162910 Positive_regulation PTBP1 TLR7 24647761 2936356 Positive_regulation PTBP1 TLR7 24705920 2949282 Positive_regulation PTBP1 TLR7 24847328 912720 Positive_regulation PTBP1 TLR7 24847328 912780 Positive_regulation PTBP1 TLR7 25084094 2994112 Positive_regulation PTBP1 TLR7 25084094 2994113 Positive_regulation PTBP1 TLR7 25084094 2994157 Positive_regulation PTBP1 TLR7 25093822 2995303 Positive_regulation PTBP1 TLR7 25111504 2996275 Positive_regulation PTBP1 TLR7 25177709 1623178 Positive_regulation PTBP1 TLR7 25317131 2006766 Positive_regulation PTBP1 TLR7 25317131 2006806 Positive_regulation PTBP1 TLR7 25429207 3216538 Positive_regulation PTBP1 TLR7 25505783 873239 Positive_regulation PTBP1 TLR7 25615690 3070831 Positive_regulation PTBP1 TLR7 PMC2767622 3125153 Positive_regulation PTBP1 TNF 11304549 1519269 Positive_regulation PTBP1 TNF 11686890 3103560 Positive_regulation PTBP1 TNF 11781361 1522111 Positive_regulation PTBP1 TNF 11927638 1523223 Positive_regulation PTBP1 TNF 11927638 1523234 Positive_regulation PTBP1 TNF 12486107 1525645 Positive_regulation PTBP1 TNF 14734523 1530716 Positive_regulation PTBP1 TNF 16847068 1541181 Positive_regulation PTBP1 TNF 16847068 1541189 Positive_regulation PTBP1 TNF 17101734 1543265 Positive_regulation PTBP1 TNF 18039949 1547841 Positive_regulation PTBP1 TNF 18466643 110740 Positive_regulation PTBP1 TNF 19001481 811151 Positive_regulation PTBP1 TNF 19715582 353113 Positive_regulation PTBP1 TNF 20672047 1747581 Positive_regulation PTBP1 TNF 20827419 1216240 Positive_regulation PTBP1 TNF 21527026 649088 Positive_regulation PTBP1 TNF 21658276 508497 Positive_regulation PTBP1 TNF 21980488 2560928 Positive_regulation PTBP1 TNF 22547990 3152598 Positive_regulation PTBP1 TNF 22566829 898646 Positive_regulation PTBP1 TNF 22645622 636183 Positive_regulation PTBP1 TNF 22951718 1631181 Positive_regulation PTBP1 TNF 23627732 1699527 Positive_regulation PTBP1 TNF 23671392 2121284 Positive_regulation PTBP1 TNF 24094416 1041436 Positive_regulation PTBP1 TNF 24453940 2285318 Positive_regulation PTBP1 TNF 24667171 222859 Positive_regulation PTBP1 TNF 25111185 2996193 Positive_regulation PTBP1 TNF 25123797 368552 Positive_regulation PTBP1 TNF 25189159 1142720 Positive_regulation PTBP1 TNF 25435303 3147454 Positive_regulation PTBP1 TNF 25609892 1763565 Positive_regulation PTBP1 TNF 7561684 1590656 Positive_regulation PTBP1 TNF 9529318 1602576 Positive_regulation PTBP1 TNF 9670049 1603252 Positive_regulation PTBP1 TNF 9670049 1603253 Positive_regulation PTBP1 TNF PMC2150969 1605356 Positive_regulation PTBP1 TNFSF10 23170271 2161761 Positive_regulation PTBP1 TP63 16818672 1541031 Positive_regulation PTBP1 TP63 25371910 1623335 Positive_regulation PTBP1 TP63 25552899 743714 Positive_regulation PTBP2 CCL17 24701375 2163120 Positive_regulation PTBP2 EDN2 18195069 1548253 Positive_regulation PTBP2 EDN2 18195069 1548254 Positive_regulation PTBP2 EDN2 18195069 1548255 Positive_regulation PTBP2 EDN2 18195069 1548256 Positive_regulation PTBP2 EDN2 18195069 1548374 Positive_regulation PTBP2 EDN2 18195077 1548748 Positive_regulation PTBP2 EPHB2 20967853 135140 Positive_regulation PTBP2 EPHB2 20967853 135141 Positive_regulation PTBP2 EPHB2 20967853 135142 Positive_regulation PTBP2 EPHB2 20967853 135156 Positive_regulation PTBP2 EPHB2 20967853 135164 Positive_regulation PTBP2 EPHB2 20967853 135165 Positive_regulation PTBP2 EPHB2 20967853 135175 Positive_regulation PTBP2 EPHB2 23526794 3149821 Positive_regulation PTBP2 EPHB2 23526794 3149826 Positive_regulation PTBP2 EPHB2 25111504 2996232 Positive_regulation PTBP2 FAS 11104808 1518122 Positive_regulation PTBP2 ITGAL 23221473 3217408 Positive_regulation PTBP2 ITGB2 21980488 2560918 Positive_regulation PTBP2 ITGB2 22238634 2586747 Positive_regulation PTBP2 ITGB2 22238634 2586748 Positive_regulation PTBP2 MAP2K6 21544193 2517138 Positive_regulation PTBP2 MIP 10562317 1513061 Positive_regulation PTBP2 PTGER2 24024207 183891 Positive_regulation PTBP2 TCN1 22750193 1492603 Positive_regulation PTBP2 TLR7 12045249 1523566 Positive_regulation PTBP2 TLR7 15492123 1533688 Positive_regulation PTBP2 TLR7 15795237 1535247 Positive_regulation PTBP2 TLR7 15851485 1535657 Positive_regulation PTBP2 TLR7 17296788 1544337 Positive_regulation PTBP2 TLR7 17296788 1544431 Positive_regulation PTBP2 TLR7 17535975 1546256 Positive_regulation PTBP2 TLR7 17535975 1546261 Positive_regulation PTBP2 TLR7 17535975 1546265 Positive_regulation PTBP2 TLR7 17954572 1547368 Positive_regulation PTBP2 TLR7 17954572 1547376 Positive_regulation PTBP2 TLR7 18086320 109643 Positive_regulation PTBP2 TLR7 18458113 1550620 Positive_regulation PTBP2 TLR7 18458113 1550621 Positive_regulation PTBP2 TLR7 18458113 1550622 Positive_regulation PTBP2 TLR7 18458113 1550748 Positive_regulation PTBP2 TLR7 18533024 352255 Positive_regulation PTBP2 TLR7 19204112 1553888 Positive_regulation PTBP2 TLR7 19204112 1554002 Positive_regulation PTBP2 TLR7 19259329 1146812 Positive_regulation PTBP2 TLR7 19294011 2214879 Positive_regulation PTBP2 TLR7 19476613 113387 Positive_regulation PTBP2 TLR7 19476613 113395 Positive_regulation PTBP2 TLR7 19557165 3044231 Positive_regulation PTBP2 TLR7 19635859 1555460 Positive_regulation PTBP2 TLR7 19667062 1555542 Positive_regulation PTBP2 TLR7 19703986 1555948 Positive_regulation PTBP2 TLR7 19808251 1556426 Positive_regulation PTBP2 TLR7 20021667 1696505 Positive_regulation PTBP2 TLR7 20021667 1696530 Positive_regulation PTBP2 TLR7 20021667 1696536 Positive_regulation PTBP2 TLR7 20308362 1557857 Positive_regulation PTBP2 TLR7 20379390 1214276 Positive_regulation PTBP2 TLR7 20379390 1214316 Positive_regulation PTBP2 TLR7 20379390 1214477 Positive_regulation PTBP2 TLR7 20379390 1214573 Positive_regulation PTBP2 TLR7 20379390 1214626 Positive_regulation PTBP2 TLR7 20533427 774738 Positive_regulation PTBP2 TLR7 20533427 774792 Positive_regulation PTBP2 TLR7 20617179 3047843 Positive_regulation PTBP2 TLR7 20808670 1635232 Positive_regulation PTBP2 TLR7 21059854 1561235 Positive_regulation PTBP2 TLR7 21059854 1561275 Positive_regulation PTBP2 TLR7 21059854 1561315 Positive_regulation PTBP2 TLR7 21059854 1561355 Positive_regulation PTBP2 TLR7 21555485 1563684 Positive_regulation PTBP2 TLR7 21706041 12980 Positive_regulation PTBP2 TLR7 21738472 3052167 Positive_regulation PTBP2 TLR7 21743479 1955597 Positive_regulation PTBP2 TLR7 22019834 1955970 Positive_regulation PTBP2 TLR7 22125457 3152155 Positive_regulation PTBP2 TLR7 22125457 3152254 Positive_regulation PTBP2 TLR7 22190970 633657 Positive_regulation PTBP2 TLR7 22193989 488216 Positive_regulation PTBP2 TLR7 22383883 3055759 Positive_regulation PTBP2 TLR7 22399974 3158721 Positive_regulation PTBP2 TLR7 22566954 900426 Positive_regulation PTBP2 TLR7 22737174 636443 Positive_regulation PTBP2 TLR7 22984435 2688551 Positive_regulation PTBP2 TLR7 23112799 904823 Positive_regulation PTBP2 TLR7 23162764 2161527 Positive_regulation PTBP2 TLR7 23202469 3221609 Positive_regulation PTBP2 TLR7 23202469 3221610 Positive_regulation PTBP2 TLR7 23202493 3221728 Positive_regulation PTBP2 TLR7 23221477 3217452 Positive_regulation PTBP2 TLR7 23223197 3221951 Positive_regulation PTBP2 TLR7 23227255 2725917 Positive_regulation PTBP2 TLR7 23300676 2734622 Positive_regulation PTBP2 TLR7 23484075 179327 Positive_regulation PTBP2 TLR7 23497717 128070 Positive_regulation PTBP2 TLR7 23557436 359125 Positive_regulation PTBP2 TLR7 23593527 2371852 Positive_regulation PTBP2 TLR7 23630623 2785353 Positive_regulation PTBP2 TLR7 23653115 1919868 Positive_regulation PTBP2 TLR7 23690937 2793831 Positive_regulation PTBP2 TLR7 23691339 1151728 Positive_regulation PTBP2 TLR7 23762810 2162428 Positive_regulation PTBP2 TLR7 23781253 637848 Positive_regulation PTBP2 TLR7 24020520 1869592 Positive_regulation PTBP2 TLR7 24204367 909743 Positive_regulation PTBP2 TLR7 24228229 2162685 Positive_regulation PTBP2 TLR7 24335833 1736520 Positive_regulation PTBP2 TLR7 24482744 2162880 Positive_regulation PTBP2 TLR7 24647761 2936326 Positive_regulation PTBP2 TLR7 24705920 2949242 Positive_regulation PTBP2 TLR7 24847328 912690 Positive_regulation PTBP2 TLR7 24847328 912750 Positive_regulation PTBP2 TLR7 25084094 2994052 Positive_regulation PTBP2 TLR7 25084094 2994053 Positive_regulation PTBP2 TLR7 25084094 2994127 Positive_regulation PTBP2 TLR7 25093822 2995296 Positive_regulation PTBP2 TLR7 25111504 2996245 Positive_regulation PTBP2 TLR7 25177709 1623148 Positive_regulation PTBP2 TLR7 25317131 2006736 Positive_regulation PTBP2 TLR7 25317131 2006776 Positive_regulation PTBP2 TLR7 25429207 3216488 Positive_regulation PTBP2 TLR7 25505783 873209 Positive_regulation PTBP2 TLR7 25615690 3070801 Positive_regulation PTBP2 TLR7 PMC2767622 3125123 Positive_regulation PTBP2 TNF 11304549 1519263 Positive_regulation PTBP2 TNF 11686890 3103551 Positive_regulation PTBP2 TNF 11781361 1522108 Positive_regulation PTBP2 TNF 11927638 1523214 Positive_regulation PTBP2 TNF 11927638 1523228 Positive_regulation PTBP2 TNF 12486107 1525642 Positive_regulation PTBP2 TNF 14734523 1530713 Positive_regulation PTBP2 TNF 16847068 1541178 Positive_regulation PTBP2 TNF 16847068 1541186 Positive_regulation PTBP2 TNF 17101734 1543261 Positive_regulation PTBP2 TNF 18039949 1547838 Positive_regulation PTBP2 TNF 18466643 110703 Positive_regulation PTBP2 TNF 19001481 811145 Positive_regulation PTBP2 TNF 19715582 353107 Positive_regulation PTBP2 TNF 20672047 1747578 Positive_regulation PTBP2 TNF 20827419 1216237 Positive_regulation PTBP2 TNF 21527026 649078 Positive_regulation PTBP2 TNF 21658276 508494 Positive_regulation PTBP2 TNF 21980488 2560916 Positive_regulation PTBP2 TNF 22547990 3152594 Positive_regulation PTBP2 TNF 22566829 898643 Positive_regulation PTBP2 TNF 22645622 636180 Positive_regulation PTBP2 TNF 22951718 1631175 Positive_regulation PTBP2 TNF 23627732 1699524 Positive_regulation PTBP2 TNF 23671392 2121269 Positive_regulation PTBP2 TNF 24094416 1041420 Positive_regulation PTBP2 TNF 24453940 2285315 Positive_regulation PTBP2 TNF 24667171 222850 Positive_regulation PTBP2 TNF 25111185 2996190 Positive_regulation PTBP2 TNF 25123797 368545 Positive_regulation PTBP2 TNF 25189159 1142717 Positive_regulation PTBP2 TNF 25435303 3147451 Positive_regulation PTBP2 TNF 25609892 1763562 Positive_regulation PTBP2 TNF 7561684 1590653 Positive_regulation PTBP2 TNF 9529318 1602570 Positive_regulation PTBP2 TNF 9670049 1603237 Positive_regulation PTBP2 TNF 9670049 1603238 Positive_regulation PTBP2 TNF PMC2150969 1605353 Positive_regulation PTBP2 TNFSF10 23170271 2161758 Positive_regulation PTBP2 TP63 16818672 1541004 Positive_regulation PTBP2 TP63 25371910 1623326 Positive_regulation PTBP2 TP63 25552899 743689 Positive_regulation PTEN ALDH2 22524197 358551 Positive_regulation PTEN CCND1 19884989 3075013 Positive_regulation PTEN EPHB2 22666537 3130617 Positive_regulation PTEN EPHB2 25058005 2992018 Positive_regulation PTEN EPHB2 25058005 2992019 Positive_regulation PTEN EPHB2 25058005 2992039 Positive_regulation PTEN FOXO1 19578399 2309531 Positive_regulation PTEN FOXO1 21179458 2488036 Positive_regulation PTEN FOXO1 24962166 1702257 Positive_regulation PTEN ID1 21293053 2174744 Positive_regulation PTEN IFI27 23936141 2829500 Positive_regulation PTEN TM4SF19 25344917 2206234 Positive_regulation PTF1A CPA4 24843545 1493548 Positive_regulation PTGDS IL1B 19094210 112267 Positive_regulation PTGDS IL1B 19094210 112268 Positive_regulation PTGER2 HCG11 20705717 1885373 Positive_regulation PTGER2 HCG14 20705717 1885374 Positive_regulation PTGER2 HCG15 20705717 1885375 Positive_regulation PTGER2 HCG16 20705717 1885378 Positive_regulation PTGER2 HCG17 20705717 1885389 Positive_regulation PTGER2 HCG18 20705717 1885388 Positive_regulation PTGER2 HCG20 20705717 1885386 Positive_regulation PTGER2 HCG21 20705717 1885387 Positive_regulation PTGER2 HCG22 20705717 1885384 Positive_regulation PTGER2 HCG23 20705717 1885376 Positive_regulation PTGER2 HCG24 20705717 1885382 Positive_regulation PTGER2 HCG25 20705717 1885377 Positive_regulation PTGER2 HCG26 20705717 1885385 Positive_regulation PTGER2 HCG27 20705717 1885383 Positive_regulation PTGER2 HCG4 20705717 1885379 Positive_regulation PTGER2 HCG8 20705717 1885380 Positive_regulation PTGER2 HCG9 20705717 1885381 Positive_regulation PTGER2 IL1A 25237386 1651025 Positive_regulation PTGER2 IL2 23760060 2117473 Positive_regulation PTGER2 NOS2 19222857 1655621 Positive_regulation PTGER2 PGF 24379787 963158 Positive_regulation PTGER2 PGR 20948178 3079134 Positive_regulation PTGER2 PRKACB 19561612 1952590 Positive_regulation PTGER2 PRKACB 25327961 216588 Positive_regulation PTGER2 PRKACG 19561612 1952591 Positive_regulation PTGER2 PRKACG 25327961 216589 Positive_regulation PTGER2 PRKAR1A 19561612 1952592 Positive_regulation PTGER2 PRKAR1A 25327961 216590 Positive_regulation PTGER2 PRKAR1B 19561612 1952593 Positive_regulation PTGER2 PRKAR1B 25327961 216591 Positive_regulation PTGER2 PRKAR2A 19561612 1952594 Positive_regulation PTGER2 PRKAR2A 25327961 216592 Positive_regulation PTGER2 PRKAR2B 19561612 1952595 Positive_regulation PTGER2 PRKAR2B 25327961 216593 Positive_regulation PTGER2 PTGER1 20939055 1237879 Positive_regulation PTGER2 PTGER3 22938033 292427 Positive_regulation PTGER2 PTGER3 23971009 864260 Positive_regulation PTGER2 PTGER4 23523686 2249451 Positive_regulation PTGER2 PTGS1 22022466 2563207 Positive_regulation PTGER2 PTGS2 19222857 1655622 Positive_regulation PTGER2 PTGS2 22012553 494163 Positive_regulation PTGER2 TLR4 23024463 1750604 Positive_regulation PTGER3 PTGER2 22938033 292428 Positive_regulation PTGER4 PTGER2 23523686 2249454 Positive_regulation PTGES IL1B 15203568 1739649 Positive_regulation PTGES IL1B 15203568 1739680 Positive_regulation PTGES IL1B 23437094 2755572 Positive_regulation PTGES IL1B 25049477 136122 Positive_regulation PTGES TNF 15225371 101369 Positive_regulation PTGES TNF 15225371 101386 Positive_regulation PTGES TNF 15899061 103839 Positive_regulation PTGES3 JAG1 22351600 778076 Positive_regulation PTGES3 JAG1 22351600 778093 Positive_regulation PTGES3 JAG1 22351600 778102 Positive_regulation PTGES3 JAG1 22351600 778106 Positive_regulation PTGES3 MAP2K6 23409030 2753288 Positive_regulation PTGES3 TNF 24580841 3169885 Positive_regulation PTGES3 ZFP57 25032857 577385 Positive_regulation PTGES3 ZFP57 25032857 577457 Positive_regulation PTGS1 EDN2 17107625 1845940 Positive_regulation PTGS1 IL1B 9927229 1764293 Positive_regulation PTGS1 IL1B 9927229 1764322 Positive_regulation PTGS2 ALOX5 24064666 1920005 Positive_regulation PTGS2 ALOX5 24516658 2921371 Positive_regulation PTGS2 ALOX5 24886817 1127351 Positive_regulation PTGS2 ARSA 20046412 3231734 Positive_regulation PTGS2 AXIN2 21711594 519061 Positive_regulation PTGS2 CCND1 17206280 2374499 Positive_regulation PTGS2 CCND1 21152316 1090437 Positive_regulation PTGS2 CD14 22923191 488343 Positive_regulation PTGS2 CD14 24829682 1769054 Positive_regulation PTGS2 EDN2 18475724 1745845 Positive_regulation PTGS2 EPHB2 11219386 98338 Positive_regulation PTGS2 EPHB2 16091148 524446 Positive_regulation PTGS2 EPHB2 16685273 427672 Positive_regulation PTGS2 EPHB2 18404483 3088087 Positive_regulation PTGS2 EPHB2 22675459 2648592 Positive_regulation PTGS2 EPHB2 22675459 2648688 Positive_regulation PTGS2 EPHB2 22675459 2648705 Positive_regulation PTGS2 EPHB2 22927840 23038 Positive_regulation PTGS2 EPHB2 23690670 1752174 Positive_regulation PTGS2 EPHB2 23875162 647277 Positive_regulation PTGS2 EPHB2 23875162 647278 Positive_regulation PTGS2 EPHB2 24084727 1113092 Positive_regulation PTGS2 EPHB2 24209633 221076 Positive_regulation PTGS2 EPHB2 24385109 1880238 Positive_regulation PTGS2 EPHB2 24551170 2923250 Positive_regulation PTGS2 EPHB2 24916153 399891 Positive_regulation PTGS2 EPHB2 24916153 399912 Positive_regulation PTGS2 F2R 24927773 3102524 Positive_regulation PTGS2 HBEGF 24303162 2251539 Positive_regulation PTGS2 IL1B 10704072 1736854 Positive_regulation PTGS2 IL1B 10704072 1736856 Positive_regulation PTGS2 IL1B 11132768 1737176 Positive_regulation PTGS2 IL1B 11132768 1737177 Positive_regulation PTGS2 IL1B 11132768 1737221 Positive_regulation PTGS2 IL1B 11200365 1737625 Positive_regulation PTGS2 IL1B 11200365 1737626 Positive_regulation PTGS2 IL1B 14627219 1049560 Positive_regulation PTGS2 IL1B 15040812 350454 Positive_regulation PTGS2 IL1B 15203568 1739681 Positive_regulation PTGS2 IL1B 15203568 1739697 Positive_regulation PTGS2 IL1B 16410651 735943 Positive_regulation PTGS2 IL1B 17570155 395250 Positive_regulation PTGS2 IL1B 20426870 3098283 Positive_regulation PTGS2 IL1B 23717664 2798670 Positive_regulation PTGS2 IL1B 23844276 2226532 Positive_regulation PTGS2 IL1B 24889212 34073 Positive_regulation PTGS2 IL1B 25038797 274282 Positive_regulation PTGS2 IL1B 9539025 797783 Positive_regulation PTGS2 IL1B 9927229 1764232 Positive_regulation PTGS2 IL1B 9927229 1764323 Positive_regulation PTGS2 IL1B 9927229 1764325 Positive_regulation PTGS2 MAP2K6 21371008 451009 Positive_regulation PTGS2 MMP28 23688423 314080 Positive_regulation PTGS2 MMP28 23688423 314544 Positive_regulation PTGS2 MMP28 24817792 1758542 Positive_regulation PTGS2 MMP7 23688423 314105 Positive_regulation PTGS2 MMP7 23688423 314561 Positive_regulation PTGS2 MMP7 24817792 1758557 Positive_regulation PTGS2 OXTR 20626426 653835 Positive_regulation PTGS2 PTGER2 19222857 1655623 Positive_regulation PTGS2 PTGER2 22012553 494164 Positive_regulation PTGS2 PTGER2 24003391 81849 Positive_regulation PTGS2 S100B 19292913 1695991 Positive_regulation PTGS2 S100B 20827421 513025 Positive_regulation PTGS2 S100B 23358382 1149027 Positive_regulation PTGS2 S100B 23358382 1149028 Positive_regulation PTGS2 S100B 24575418 1495699 Positive_regulation PTGS2 SPHK1 23818902 2119915 Positive_regulation PTGS2 SPHK1 24385109 1880236 Positive_regulation PTGS2 SPHK1 24385109 1880259 Positive_regulation PTGS2 SYNM 21776245 1075807 Positive_regulation PTGS2 TGM2 24009824 203573 Positive_regulation PTGS2 TLR7 25083184 1078089 Positive_regulation PTGS2 TLR7 25161655 913911 Positive_regulation PTGS2 TLR7 25309919 201228 Positive_regulation PTGS2 TLR7 25549244 3036815 Positive_regulation PTGS2 TNF 11238591 1518877 Positive_regulation PTGS2 TNF 11238591 1518978 Positive_regulation PTGS2 TNF 11806848 3103649 Positive_regulation PTGS2 TNF 12466023 369115 Positive_regulation PTGS2 TNF 14627219 1049559 Positive_regulation PTGS2 TNF 14760934 1739232 Positive_regulation PTGS2 TNF 15175101 523666 Positive_regulation PTGS2 TNF 15175101 523667 Positive_regulation PTGS2 TNF 15225371 101373 Positive_regulation PTGS2 TNF 15225371 101388 Positive_regulation PTGS2 TNF 15266333 424818 Positive_regulation PTGS2 TNF 15266333 424819 Positive_regulation PTGS2 TNF 15266333 424822 Positive_regulation PTGS2 TNF 16606437 658631 Positive_regulation PTGS2 TNF 16702604 1540326 Positive_regulation PTGS2 TNF 16859534 106334 Positive_regulation PTGS2 TNF 18475724 1745850 Positive_regulation PTGS2 TNF 19196878 3102638 Positive_regulation PTGS2 TNF 19287485 2408007 Positive_regulation PTGS2 TNF 19570240 626833 Positive_regulation PTGS2 TNF 20219134 1504087 Positive_regulation PTGS2 TNF 20585313 1717658 Positive_regulation PTGS2 TNF 20953381 1748552 Positive_regulation PTGS2 TNF 20976153 2479073 Positive_regulation PTGS2 TNF 21294864 121431 Positive_regulation PTGS2 TNF 21687748 922434 Positive_regulation PTGS2 TNF 22025971 85664 Positive_regulation PTGS2 TNF 22028854 2564549 Positive_regulation PTGS2 TNF 22034110 735017 Positive_regulation PTGS2 TNF 22108456 508642 Positive_regulation PTGS2 TNF 22396737 2608355 Positive_regulation PTGS2 TNF 22396737 2608453 Positive_regulation PTGS2 TNF 22479607 2616274 Positive_regulation PTGS2 TNF 22605974 1095607 Positive_regulation PTGS2 TNF 22666431 2648086 Positive_regulation PTGS2 TNF 22768286 2660449 Positive_regulation PTGS2 TNF 22832605 3189144 Positive_regulation PTGS2 TNF 23008778 1151607 Positive_regulation PTGS2 TNF 23008778 1151610 Positive_regulation PTGS2 TNF 23024463 1750599 Positive_regulation PTGS2 TNF 23056034 3075985 Positive_regulation PTGS2 TNF 23326670 3081094 Positive_regulation PTGS2 TNF 23346188 817060 Positive_regulation PTGS2 TNF 23573150 818511 Positive_regulation PTGS2 TNF 23573150 818515 Positive_regulation PTGS2 TNF 23675573 944098 Positive_regulation PTGS2 TNF 23688423 314070 Positive_regulation PTGS2 TNF 23688423 314071 Positive_regulation PTGS2 TNF 23688423 314072 Positive_regulation PTGS2 TNF 23688423 314073 Positive_regulation PTGS2 TNF 23688423 314074 Positive_regulation PTGS2 TNF 23688423 314075 Positive_regulation PTGS2 TNF 23688423 314160 Positive_regulation PTGS2 TNF 23688423 314168 Positive_regulation PTGS2 TNF 23688423 314173 Positive_regulation PTGS2 TNF 23688423 314538 Positive_regulation PTGS2 TNF 23688423 314539 Positive_regulation PTGS2 TNF 23688423 314564 Positive_regulation PTGS2 TNF 23700398 1039685 Positive_regulation PTGS2 TNF 23700398 1039693 Positive_regulation PTGS2 TNF 23717114 1614105 Positive_regulation PTGS2 TNF 23717114 1614116 Positive_regulation PTGS2 TNF 23823806 2808869 Positive_regulation PTGS2 TNF 23894351 2824230 Positive_regulation PTGS2 TNF 24005861 1110839 Positive_regulation PTGS2 TNF 24016040 294972 Positive_regulation PTGS2 TNF 24069158 2851452 Positive_regulation PTGS2 TNF 24143232 2868025 Positive_regulation PTGS2 TNF 24151615 184547 Positive_regulation PTGS2 TNF 24156000 1713086 Positive_regulation PTGS2 TNF 24283517 130115 Positive_regulation PTGS2 TNF 24349530 2898419 Positive_regulation PTGS2 TNF 24349530 2898423 Positive_regulation PTGS2 TNF 24351869 1122547 Positive_regulation PTGS2 TNF 24379887 825005 Positive_regulation PTGS2 TNF 24600193 2248346 Positive_regulation PTGS2 TNF 24616552 1757581 Positive_regulation PTGS2 TNF 24734105 825545 Positive_regulation PTGS2 TNF 24734105 825546 Positive_regulation PTGS2 TNF 24818101 947837 Positive_regulation PTGS2 TNF 24977407 2985301 Positive_regulation PTGS2 TNF 25126080 965775 Positive_regulation PTGS2 TNF 25318054 1132433 Positive_regulation PTGS2 TNF 25343247 3019007 Positive_regulation PTGS2 TNF 25374748 82616 Positive_regulation PTGS2 TNF 25379003 1615509 Positive_regulation PTGS2 TNF 25379003 1615512 Positive_regulation PTGS2 TNF 25379003 1615513 Positive_regulation PTGS2 TNF 25379003 1615515 Positive_regulation PTGS2 TNF 25379003 1615522 Positive_regulation PTGS2 TNF 25379003 1615529 Positive_regulation PTGS2 TNF 25383223 1083595 Positive_regulation PTGS2 TNF 25423092 3029890 Positive_regulation PTGS2 TNF 9547339 1602656 Positive_regulation PTGS2 TNFSF10 25299780 578228 Positive_regulation PTGS2 TNFSF10 PMC4212306 3206579 Positive_regulation PTH CTGF 24049536 95882 Positive_regulation PTH CTGF 24049536 95886 Positive_regulation PTHLH CCND1 24286177 130763 Positive_regulation PTHLH CTGF 24551846 187116 Positive_regulation PTHLH IL1B PMC3373826 297849 Positive_regulation PTHLH TNF 20953899 645852 Positive_regulation PTK2 CAPN8 10545505 1252238 Positive_regulation PTK2 CAPN8 10545505 1252239 Positive_regulation PTK2 CAPN8 10545505 1252315 Positive_regulation PTK2 CAPN8 10545505 1252362 Positive_regulation PTK2 CAPN8 PMC2151180 1474775 Positive_regulation PTK2 CAPN8 PMC2164972 1474806 Positive_regulation PTK2 TNF 7519620 1436175 Positive_regulation PTK2 TNF 8769427 1455876 Positive_regulation PTK2B NEDD9 25594051 2173915 Positive_regulation PTK6 TNF 7519620 1436176 Positive_regulation PTK6 TNF 8769427 1455877 Positive_regulation PTK7 TNF 7519620 1436177 Positive_regulation PTK7 TNF 8769427 1455878 Positive_regulation PTPN1 TNF 24349514 2898389 Positive_regulation PTPN11 EPHB2 17616983 2289425 Positive_regulation PTPN11 EPHB2 19737390 526080 Positive_regulation PTPN11 MMP28 21909258 3053187 Positive_regulation PTPN11 MMP7 21909258 3053202 Positive_regulation PTPN11 RGS2 21663700 1229233 Positive_regulation PTPN13 FAS 23559010 561093 Positive_regulation PTPN13 FAS 24316673 1930414 Positive_regulation PTPN2 TNF 22377701 737171 Positive_regulation PTPN2 TNF 22457781 2613730 Positive_regulation PTPN22 EPHB2 24131623 270106 Positive_regulation PTPN5 CAPN8 23239949 3229421 Positive_regulation PTPN5 CAPN8 24416390 2908221 Positive_regulation PTPN6 ANGPT1 22454630 832648 Positive_regulation PTPN6 CAPN8 22937084 2682917 Positive_regulation PTPN6 CD22 16630358 105903 Positive_regulation PTPN6 CD22 8627166 1596122 Positive_regulation PTPRB ANGPT1 19451274 1366060 Positive_regulation PTPRB ANGPT1 19451274 1366067 Positive_regulation PTPRB ANGPT1 23575676 1935927 Positive_regulation PTPRC CD14 21209798 1084120 Positive_regulation PTPRC CD14 8760823 1598959 Positive_regulation PTPRC PECAM1 23054369 1654678 Positive_regulation PTPRC PECAM1 24312447 2889510 Positive_regulation PTPRJ TNF 24016860 129753 Positive_regulation PTTG1 CLU 21464964 2510705 Positive_regulation PTTG1 EPHB2 25421944 349499 Positive_regulation PTTG1 PLAU 23164239 267018 Positive_regulation PTTG2 CLU 21464964 2510706 Positive_regulation PTTG2 PLAU 23164239 267020 Positive_regulation PTX3 IL1B 23401658 1915573 Positive_regulation PTX3 IL1B 23401658 1915574 Positive_regulation PTX3 TLR7 19389798 1637094 Positive_regulation PTX3 TLR7 24039869 2844985 Positive_regulation PTX3 TLR7 24060373 1700534 Positive_regulation PTX3 TNF 19014569 313015 Positive_regulation PTX3 TNF 20003354 117895 Positive_regulation PTX3 TNF 21637713 2525836 Positive_regulation PTX3 TNF 22529962 2620733 Positive_regulation PTX3 TNF 22529962 2620738 Positive_regulation PTX3 TNF 22577258 1749984 Positive_regulation PTX3 TNF 23401658 1915571 Positive_regulation PTX3 TNF 23401658 1915576 Positive_regulation PTX3 TNF 23401658 1915582 Positive_regulation PTX3 TNF 23401658 1915601 Positive_regulation PTX3 TNF 23401658 1915604 Positive_regulation PTX3 TNF 23483012 878150 Positive_regulation PTX3 TNF 23755050 907389 Positive_regulation PTX3 TNF 23755050 907395 Positive_regulation PTX3 TNF 23755050 907430 Positive_regulation PTX3 TNF 23840908 2818810 Positive_regulation PTX3 TNF 24039869 2844984 Positive_regulation PTX3 TNF 24457902 2186914 Positive_regulation PTX3 TNF 24457902 2186916 Positive_regulation PTX3 TNF 24457902 2186920 Positive_regulation PTX3 TNF 24479486 1667600 Positive_regulation PTX3 TNF 25394473 133805 Positive_regulation PTX4 TNF 20003354 117893 Positive_regulation PTX4 TNF 23755050 907386 Positive_regulation PUM1 EPHB2 25349449 2250836 Positive_regulation PUM1 MAP2K6 25349449 2250842 Positive_regulation PVR TLR7 23349877 2743802 Positive_regulation PVR TLR7 23349877 2743823 Positive_regulation PVR TLR7 23349877 2743848 Positive_regulation PVR TLR7 23349877 2743875 Positive_regulation PVR TLR7 23349877 2743904 Positive_regulation PXN CAPN8 10545505 1252276 Positive_regulation PXN CAPN8 10545505 1252277 Positive_regulation PXN CAPN8 10545505 1252278 Positive_regulation PXN CAPN8 10545505 1252376 Positive_regulation PXN CAPN8 23936270 2829816 Positive_regulation PXN CAPN8 23936270 2829817 Positive_regulation PXN CAPN8 23936270 2829872 Positive_regulation PXN CAPN8 PMC2151180 1474789 Positive_regulation PXN EDN2 19527488 464470 Positive_regulation PXN EDN2 7525604 1436354 Positive_regulation PXN EDN2 7525608 1436363 Positive_regulation PXN EDN2 9064347 1600421 Positive_regulation PXN EPHB2 15132756 248343 Positive_regulation PXN EPHB2 19885391 2269669 Positive_regulation PXN EPHB2 20011539 2433639 Positive_regulation PXN EPHB2 20011539 2433640 Positive_regulation PXN EPHB2 20011539 2433641 Positive_regulation PXN EPHB2 22859931 2670473 Positive_regulation PXN F2R 15969748 1695428 Positive_regulation PXN TNF 23674089 440635 Positive_regulation PXN TNF 23674089 440636 Positive_regulation PXN TNF 23674089 440637 Positive_regulation PXN TNF 23674089 440638 Positive_regulation PXN TNF 23674089 440639 Positive_regulation PXN TNF 7525604 1436347 Positive_regulation PXN TNF 7525608 1436360 Positive_regulation PXN TNF 7525608 1436361 Positive_regulation PXN TNF 7525608 1436366 Positive_regulation PXN TNF 7525608 1436367 Positive_regulation PXN TNF 7525608 1436372 Positive_regulation PYCARD TNF 23940760 2832266 Positive_regulation PYY FAS 22844422 2668144 Positive_regulation QKI IFI27 19517016 2418932 Positive_regulation QRICH1 PGC 24304688 493410 Positive_regulation QRICH1 PGC 24304688 493411 Positive_regulation QRICH1 SLC38A3 11980913 1282136 Positive_regulation QRICH1 TNF 22754203 1044903 Positive_regulation QRICH2 PGC 24304688 493412 Positive_regulation QRICH2 PGC 24304688 493413 Positive_regulation QRICH2 SLC38A3 11980913 1282137 Positive_regulation QRICH2 TNF 22754203 1044904 Positive_regulation QSOX1 TNF 19093006 1908632 Positive_regulation QSOX2 TNF 19093006 1908631 Positive_regulation RAB10 EPHB2 22852067 3184184 Positive_regulation RAB11A TNF 22894638 1664810 Positive_regulation RAB12 EPHB2 22852067 3184155 Positive_regulation RAB13 EPHB2 22852067 3184186 Positive_regulation RAB14 EPHB2 22852067 3184133 Positive_regulation RAB15 EPHB2 22852067 3184147 Positive_regulation RAB17 EPHB2 22852067 3184131 Positive_regulation RAB18 EPHB2 22852067 3184123 Positive_regulation RAB19 EPHB2 22852067 3184143 Positive_regulation RAB20 EPHB2 22852067 3184137 Positive_regulation RAB21 EPHB2 22852067 3184139 Positive_regulation RAB21 RINL 22291991 2591630 Positive_regulation RAB22A RINL 21419809 158719 Positive_regulation RAB22A RINL 22291991 2591633 Positive_regulation RAB22A RINL 22291991 2591634 Positive_regulation RAB23 EPHB2 22852067 3184127 Positive_regulation RAB24 EPHB2 22852067 3184188 Positive_regulation RAB25 EPHB2 22852067 3184135 Positive_regulation RAB26 EPHB2 22852067 3184125 Positive_regulation RAB28 EPHB2 22852067 3184190 Positive_regulation RAB30 EPHB2 22852067 3184192 Positive_regulation RAB31 ARHGEF7 18974049 1164882 Positive_regulation RAB31 ATM 21958360 1767712 Positive_regulation RAB31 CCZ1 24501423 1822272 Positive_regulation RAB31 CHM 20027300 2435062 Positive_regulation RAB31 ELAVL1 25472813 1486015 Positive_regulation RAB31 EPHB2 22852067 3184194 Positive_regulation RAB31 GABARAPL2 20562859 1985365 Positive_regulation RAB31 GDI1 23154999 1809487 Positive_regulation RAB31 GDI2 23154999 1809488 Positive_regulation RAB31 INS 21454690 1191231 Positive_regulation RAB31 MAP1LC3A 23892275 18382 Positive_regulation RAB31 MUC1 22792175 2661054 Positive_regulation RAB31 MUC1 22792175 2661057 Positive_regulation RAB31 MUC1 22792175 2661058 Positive_regulation RAB31 MUC1 22792175 2661064 Positive_regulation RAB31 MUC1 22792175 2661065 Positive_regulation RAB31 MUC1 22792175 2661076 Positive_regulation RAB31 MUC1 22792175 2661080 Positive_regulation RAB31 MUC1 22792175 2661082 Positive_regulation RAB31 MUC1 25261375 2202229 Positive_regulation RAB31 MUC1 25261375 2202249 Positive_regulation RAB31 MUC1 25472813 1486007 Positive_regulation RAB31 NA 23892275 18409 Positive_regulation RAB31 NEUROG3 20807725 1497626 Positive_regulation RAB31 NEUROG3 20807725 1497654 Positive_regulation RAB31 OPRM1 20826607 1782514 Positive_regulation RAB31 RAB3GAP1 18463892 810137 Positive_regulation RAB31 RAB3GAP1 24312013 868056 Positive_regulation RAB31 RAB5A 25261375 2202250 Positive_regulation RAB31 RAB6A 22790194 3164471 Positive_regulation RAB31 RASA1 16769818 1330456 Positive_regulation RAB31 RASA1 22465036 3080130 Positive_regulation RAB31 RASA1 24520163 752763 Positive_regulation RAB31 RIN3 25472813 1486014 Positive_regulation RAB31 RINL 22291991 2591635 Positive_regulation RAB31 RNF19A 22852067 3184193 Positive_regulation RAB31 SLC2A4RG 22171327 1799056 Positive_regulation RAB31 SLC2A4RG 22724020 2655593 Positive_regulation RAB31 SLC2A4RG 23696742 3061567 Positive_regulation RAB31 SLC2A4RG 25332841 589923 Positive_regulation RAB31 SLC2A4RG 25472813 1486013 Positive_regulation RAB31 SLC6A4 21651512 647483 Positive_regulation RAB31 STX3 22820376 1928496 Positive_regulation RAB31 TBC1D25 21383079 1385589 Positive_regulation RAB31 TBC1D4 24843827 589763 Positive_regulation RAB32 EPHB2 22852067 3184196 Positive_regulation RAB34 EPHB2 22852067 3184129 Positive_regulation RAB35 EPHB2 22852067 3184198 Positive_regulation RAB36 EPHB2 22852067 3184200 Positive_regulation RAB37 EPHB2 22852067 3184153 Positive_regulation RAB38 EPHB2 22852067 3184202 Positive_regulation RAB41 EPHB2 22852067 3184141 Positive_regulation RAB42 EPHB2 22852067 3184151 Positive_regulation RAB43 EPHB2 22852067 3184145 Positive_regulation RAB44 EPHB2 22852067 3184149 Positive_regulation RAB5A NT5E 21423773 2508330 Positive_regulation RAB5A RAB31 25261375 2202252 Positive_regulation RAB5A RINL 21419809 158720 Positive_regulation RAB5A RINL 22291991 2591636 Positive_regulation RAB5A TF 23285084 2732439 Positive_regulation RAB5B RINL 22291991 2591617 Positive_regulation RAB6A RAB31 22790194 3164498 Positive_regulation RAB7A FOXO1 22622703 142858 Positive_regulation RAB7A FOXO1 23434668 1102092 Positive_regulation RAB7A FOXO1 24265619 962936 Positive_regulation RAB7A FOXO1 24889822 1483439 Positive_regulation RAB7A FOXO1 25247581 1130857 Positive_regulation RABEPK TLR7 19430534 2416289 Positive_regulation RABEPK TLR7 19703985 1555914 Positive_regulation RABEPK TLR7 23071254 1569615 Positive_regulation RABEPK TLR7 23967307 2836074 Positive_regulation RABEPK TLR7 PMC4126180 787211 Positive_regulation RABEPK TNF 17927586 1030469 Positive_regulation RABEPK TNF 23700396 1039653 Positive_regulation RABEPK TP63 23226202 2723583 Positive_regulation RABGEF1 NEDD9 25594051 2173923 Positive_regulation RAC1 ANGPT1 16157706 1324017 Positive_regulation RAC1 ANGPT1 16157706 1324021 Positive_regulation RAC1 ANGPT1 16157706 1324022 Positive_regulation RAC1 ANGPT1 24278675 3150022 Positive_regulation RAC1 CAPN8 11062268 1264688 Positive_regulation RAC1 CAPN8 11062268 1264838 Positive_regulation RAC1 CAPN8 11062268 1264839 Positive_regulation RAC1 CAPN8 11062268 1264954 Positive_regulation RAC1 CAPN8 11062268 1264999 Positive_regulation RAC1 CAPN8 21912722 2223946 Positive_regulation RAC1 CAPN8 PMC2185599 1475312 Positive_regulation RAC1 EPHB2 11980921 1282395 Positive_regulation RAC1 EPHB2 19015320 1361574 Positive_regulation RAC1 EPHB2 19182796 1965179 Positive_regulation RAC1 EPHB2 19182796 1965184 Positive_regulation RAC1 EPHB2 20071600 712776 Positive_regulation RAC1 EPHB2 21765460 2141033 Positive_regulation RAC1 EPHB2 21980400 2560248 Positive_regulation RAC1 EPHB2 21980400 2560260 Positive_regulation RAC1 EPHB2 21980400 2560325 Positive_regulation RAC1 EPHB2 21980400 2560329 Positive_regulation RAC1 EPHB2 22511753 1203206 Positive_regulation RAC1 EPHB2 22701712 2652229 Positive_regulation RAC1 EPHB2 22970259 2687863 Positive_regulation RAC1 EPHB2 23208503 2150192 Positive_regulation RAC1 EPHB2 23389627 1811817 Positive_regulation RAC1 EPHB2 23797476 2156900 Positive_regulation RAC1 EPHB2 23797476 2156901 Positive_regulation RAC1 EPHB2 23969997 839422 Positive_regulation RAC1 EPHB2 24632816 2934275 Positive_regulation RAC1 EPHB2 25123138 1129037 Positive_regulation RAC1 EPHB2 25123138 1129039 Positive_regulation RAC1 F2R 21134286 1696935 Positive_regulation RAC1 F2R 24215724 538227 Positive_regulation RAC1 F2R 24860547 880628 Positive_regulation RAC1 FZD4 22325146 1864803 Positive_regulation RAC1 FZD4 23593172 2780086 Positive_regulation RAC1 GAB3 21118992 1783672 Positive_regulation RAC1 IFI27 21526108 1685646 Positive_regulation RAC1 ITGAL 21206905 2491139 Positive_regulation RAC1 ITGAL 21206905 2491150 Positive_regulation RAC1 ITGB2 21206905 2491127 Positive_regulation RAC1 ITGB2 21206905 2491128 Positive_regulation RAC1 ITGB2 21206905 2491140 Positive_regulation RAC1 ITGB2 21206905 2491188 Positive_regulation RAC1 ITGB2 21206905 2491201 Positive_regulation RAC1 ITGB2 21206905 2491204 Positive_regulation RAC1 LAMB3 22673183 471597 Positive_regulation RAC1 MAP2K6 19015320 1361736 Positive_regulation RAC1 MAP2K6 23208503 2150198 Positive_regulation RAC1 PECAM1 23733346 1405449 Positive_regulation RAC1 PECAM1 23733346 1405450 Positive_regulation RAC1 PECAM1 23733346 1405471 Positive_regulation RAC1 PLAU 12952933 1296537 Positive_regulation RAC1 PLAU 12952933 1296553 Positive_regulation RAC1 PLAU 12952933 1296559 Positive_regulation RAC1 PLAU 20067638 255172 Positive_regulation RAC1 S1PR3 21304987 2502033 Positive_regulation RAC1 S1PR3 23301082 2738132 Positive_regulation RAC1 SPHK1 21304987 2502030 Positive_regulation RAC1 TLR7 21098092 1561636 Positive_regulation RAC1 TNF 23383114 2748003 Positive_regulation RAC1 TNF 23389627 1811814 Positive_regulation RAC1 TNF 23389627 1811815 Positive_regulation RAC1 TNF 23389627 1811852 Positive_regulation RAC1 TNF 23389627 1811889 Positive_regulation RAC1 TNF 23389627 1811948 Positive_regulation RAC1 TNF 23789107 169897 Positive_regulation RAC1 TNF 23789107 169916 Positive_regulation RAC2 CAPN8 11062268 1264702 Positive_regulation RAC2 CAPN8 11062268 1264866 Positive_regulation RAC2 CAPN8 11062268 1264867 Positive_regulation RAC2 CAPN8 11062268 1264968 Positive_regulation RAC2 CAPN8 11062268 1265013 Positive_regulation RAC2 CAPN8 PMC2185599 1475326 Positive_regulation RAC2 EPHB2 11980921 1282396 Positive_regulation RAC2 EPHB2 22511753 1203207 Positive_regulation RAC2 EPHB2 23389627 1811822 Positive_regulation RAC2 F2R 21134286 1696936 Positive_regulation RAC2 F2R 24215724 538229 Positive_regulation RAC2 F2R 24860547 880630 Positive_regulation RAC2 FZD4 22325146 1864813 Positive_regulation RAC2 FZD4 23593172 2780107 Positive_regulation RAC2 ITGAL 21206905 2491141 Positive_regulation RAC2 ITGB2 21206905 2491130 Positive_regulation RAC2 ITGB2 21206905 2491131 Positive_regulation RAC2 ITGB2 21206905 2491142 Positive_regulation RAC2 ITGB2 21206905 2491189 Positive_regulation RAC2 ITGB2 21206905 2491198 Positive_regulation RAC2 ITGB2 21206905 2491202 Positive_regulation RAC2 ITGB2 21206905 2491205 Positive_regulation RAC2 PECAM1 23733346 1405472 Positive_regulation RAC2 PLAU 12952933 1296539 Positive_regulation RAC2 PLAU 12952933 1296554 Positive_regulation RAC2 PLAU 12952933 1296560 Positive_regulation RAC2 S1PR3 21304987 2502035 Positive_regulation RAC2 S1PR3 23301082 2738137 Positive_regulation RAC2 TNF 23389627 1811819 Positive_regulation RAC2 TNF 23389627 1811820 Positive_regulation RAC2 TNF 23389627 1811853 Positive_regulation RAC2 TNF 23389627 1811892 Positive_regulation RAC2 TNF 23389627 1811949 Positive_regulation RAC3 CAPN8 11062268 1264716 Positive_regulation RAC3 CAPN8 11062268 1264894 Positive_regulation RAC3 CAPN8 11062268 1264895 Positive_regulation RAC3 CAPN8 11062268 1264982 Positive_regulation RAC3 CAPN8 11062268 1265027 Positive_regulation RAC3 CAPN8 PMC2185599 1475340 Positive_regulation RAC3 EPHB2 11980921 1282397 Positive_regulation RAC3 EPHB2 22511753 1203208 Positive_regulation RAC3 EPHB2 23389627 1811827 Positive_regulation RAC3 F2R 21134286 1696937 Positive_regulation RAC3 F2R 24215724 538231 Positive_regulation RAC3 F2R 24860547 880632 Positive_regulation RAC3 FZD4 22325146 1864823 Positive_regulation RAC3 FZD4 23593172 2780128 Positive_regulation RAC3 ITGB2 21206905 2491133 Positive_regulation RAC3 ITGB2 21206905 2491203 Positive_regulation RAC3 PECAM1 23733346 1405473 Positive_regulation RAC3 PLAU 12952933 1296541 Positive_regulation RAC3 PLAU 12952933 1296555 Positive_regulation RAC3 PLAU 12952933 1296561 Positive_regulation RAC3 S1PR3 21304987 2502037 Positive_regulation RAC3 S1PR3 23301082 2738142 Positive_regulation RAC3 TNF 23389627 1811824 Positive_regulation RAC3 TNF 23389627 1811825 Positive_regulation RAC3 TNF 23389627 1811854 Positive_regulation RAC3 TNF 23389627 1811895 Positive_regulation RAC3 TNF 23389627 1811950 Positive_regulation RAD23B TNF 7519620 1436162 Positive_regulation RAD23B TNF 7519620 1436163 Positive_regulation RAD23B TNF 7519620 1436178 Positive_regulation RAD50 EPHB2 23758320 151632 Positive_regulation RAD50 PECAM1 10725328 1256536 Positive_regulation RAD50 PECAM1 10725328 1256537 Positive_regulation RAD50 PECAM1 10725328 1256576 Positive_regulation RAD50 TNF 16043520 1536945 Positive_regulation RAD51 ANO1 22690333 86545 Positive_regulation RAD51 TNF 25310191 3015019 Positive_regulation RAD51 TNF 25310191 3015020 Positive_regulation RAD51 TNF 25310191 3015024 Positive_regulation RAE1 TLR7 23316194 905658 Positive_regulation RAE1 TNF 25333972 3018168 Positive_regulation RAET1E MYC 23166357 1569885 Positive_regulation RAF1 EPHB2 18335053 2387047 Positive_regulation RAF1 EPHB2 19383130 525252 Positive_regulation RAF1 EPHB2 22384111 2604122 Positive_regulation RAF1 EPHB2 22567280 622892 Positive_regulation RAF1 EPHB2 23209424 2340111 Positive_regulation RAF1 EPHB2 24667437 2938715 Positive_regulation RAF1 FAS 16365167 1326368 Positive_regulation RAF1 FAS 16365167 1326372 Positive_regulation RAF1 MAP2K6 17922568 2289528 Positive_regulation RAF1 MAP2K6 21411864 2175688 Positive_regulation RAF1 MAP2K6 22384111 2604128 Positive_regulation RAF1 MAP2K6 23085539 2181472 Positive_regulation RAF1 MAP2K6 25411776 3028870 Positive_regulation RAF1 MUC16 17391532 3108162 Positive_regulation RAG1 EPHB2 14624253 2255184 Positive_regulation RAG1 FOXO1 18978794 1951883 Positive_regulation RAG1 FOXO1 18978794 1951891 Positive_regulation RAG1 FOXO1 18978794 1951899 Positive_regulation RAG1 FOXO1 18978794 1951911 Positive_regulation RAG1 FOXO1 18978794 1951917 Positive_regulation RAG1 FOXO1 20543837 1953873 Positive_regulation RAG1 FOXO1 21655267 2527786 Positive_regulation RAG1 FOXO1 21655267 2527787 Positive_regulation RAG1 FOXO1 21655267 2527801 Positive_regulation RAG1 FOXO1 21655267 2527802 Positive_regulation RAG1 FOXO1 21655267 2527814 Positive_regulation RAG1 FOXO1 21655267 2527828 Positive_regulation RAG1 FOXO1 22997486 656249 Positive_regulation RAG1 FOXO1 23878308 1572770 Positive_regulation RAG1 FOXO1 23878308 1572771 Positive_regulation RAG1 FOXO1 23878308 1572772 Positive_regulation RAG1 FOXO1 23878308 1572802 Positive_regulation RAG1 FOXO1 23878308 1572803 Positive_regulation RAG1 FOXO1 23878308 1572824 Positive_regulation RAG1 FOXO1 23878308 1572825 Positive_regulation RAG1 FOXO1 23878308 1572873 Positive_regulation RAG1 FOXO1 23878308 1572878 Positive_regulation RAG1 FOXO1 25400915 1037164 Positive_regulation RAG2 FOXO1 18978794 1951884 Positive_regulation RAG2 FOXO1 18978794 1951900 Positive_regulation RAG2 FOXO1 18978794 1951912 Positive_regulation RAG2 FOXO1 18978794 1951918 Positive_regulation RAG2 FOXO1 20543837 1953874 Positive_regulation RAG2 FOXO1 21655267 2527790 Positive_regulation RAG2 FOXO1 21655267 2527791 Positive_regulation RAG2 FOXO1 21655267 2527805 Positive_regulation RAG2 FOXO1 21655267 2527806 Positive_regulation RAG2 FOXO1 21655267 2527818 Positive_regulation RAG2 FOXO1 21655267 2527831 Positive_regulation RAG2 FOXO1 22997486 656250 Positive_regulation RAG2 FOXO1 23878308 1572781 Positive_regulation RAG2 FOXO1 23878308 1572782 Positive_regulation RAG2 FOXO1 23878308 1572783 Positive_regulation RAG2 FOXO1 23878308 1572805 Positive_regulation RAG2 FOXO1 23878308 1572806 Positive_regulation RAG2 FOXO1 23878308 1572831 Positive_regulation RAG2 FOXO1 23878308 1572832 Positive_regulation RAG2 FOXO1 23878308 1572875 Positive_regulation RAG2 FOXO1 23878308 1572880 Positive_regulation RALA IFI27 23576547 1813441 Positive_regulation RALA IFI27 23576547 1813442 Positive_regulation RALA MAP2K6 20003375 254847 Positive_regulation RALB IFI27 23576547 1813444 Positive_regulation RALBP1 IFI27 23576547 1813445 Positive_regulation RAN NES 11149926 1267022 Positive_regulation RAN NES 11149926 1267025 Positive_regulation RAN NES 11149926 1267033 Positive_regulation RAN NES 11149926 1267034 Positive_regulation RAN NES 11238447 1267504 Positive_regulation RANBP1 NES 8794858 1455937 Positive_regulation RANBP2 INPP4B 25126743 2998011 Positive_regulation RANBP2 TNF 21637744 2525875 Positive_regulation RANBP3 EPHB2 24247654 1721907 Positive_regulation RANBP3 NES 11425870 1271801 Positive_regulation RAPGEF2 EPHB2 17724123 1344103 Positive_regulation RARB IAPP 2438371 1611113 Positive_regulation RARB NCL 22693611 2650943 Positive_regulation RARB NCL 22693611 2650947 Positive_regulation RARB NCL 22693611 2650961 Positive_regulation RARB NR2F1 22693611 2650944 Positive_regulation RARB NR2F2 22693611 2650926 Positive_regulation RARB NR2F2 22693611 2650927 Positive_regulation RARB NR2F2 22693611 2650945 Positive_regulation RARB NR2F2 22693611 2650948 Positive_regulation RARB NR2F2 22693611 2650949 Positive_regulation RARB NR2F2 22693611 2650951 Positive_regulation RARB NR2F2 22693611 2650962 Positive_regulation RARB RARA 9255592 797245 Positive_regulation RARB RXRA 9255592 797244 Positive_regulation RARB TRIM24 23717505 2797909 Positive_regulation RASA1 ANGPT1 24013716 2842138 Positive_regulation RASA1 EPHB2 21200439 2489526 Positive_regulation RASA1 RAB31 22465036 3080157 Positive_regulation RASA1 RAB31 23878272 1406211 Positive_regulation RASA3 CA2 9874690 1612993 Positive_regulation RASA3 PIP 22384237 2607524 Positive_regulation RASAL2 EPHB2 25216515 2199634 Positive_regulation RASD1 MYLIP 23202960 1098884 Positive_regulation RASD1 NR2F6 21247419 376251 Positive_regulation RASD1 REN 21247419 376262 Positive_regulation RASGRF1 CAPN8 19678938 116520 Positive_regulation RASGRF1 CAPN8 19678938 116521 Positive_regulation RASGRP1 EPHB2 21441934 1955200 Positive_regulation RASGRP1 EPHB2 24027568 908807 Positive_regulation RASGRP1 EPHB2 24336796 752223 Positive_regulation RASGRP1 EPHB2 24336796 752228 Positive_regulation RASGRP2 EPHB2 24027568 908808 Positive_regulation RASGRP3 EPHB2 24027568 908784 Positive_regulation RASGRP4 EPHB2 24027568 908785 Positive_regulation RASSF1 TNF 24327924 1831662 Positive_regulation RASSF1 TNF 24327924 1831669 Positive_regulation RASSF1 TNF 24327924 1831670 Positive_regulation RASSF10 JUND 23552700 2156433 Positive_regulation RASSF10 PRKACB 23552700 2156379 Positive_regulation RASSF10 PRKACB 23552700 2156397 Positive_regulation RASSF10 PRKACB 23552700 2156403 Positive_regulation RASSF10 PRKACB 23552700 2156404 Positive_regulation RASSF10 PRKACB 23552700 2156421 Positive_regulation RASSF10 PRKACG 23552700 2156380 Positive_regulation RASSF10 PRKACG 23552700 2156398 Positive_regulation RASSF10 PRKACG 23552700 2156405 Positive_regulation RASSF10 PRKACG 23552700 2156406 Positive_regulation RASSF10 PRKACG 23552700 2156422 Positive_regulation RASSF10 PRKAR1A 23552700 2156381 Positive_regulation RASSF10 PRKAR1A 23552700 2156399 Positive_regulation RASSF10 PRKAR1A 23552700 2156407 Positive_regulation RASSF10 PRKAR1A 23552700 2156408 Positive_regulation RASSF10 PRKAR1A 23552700 2156423 Positive_regulation RASSF10 PRKAR1B 23552700 2156382 Positive_regulation RASSF10 PRKAR1B 23552700 2156400 Positive_regulation RASSF10 PRKAR1B 23552700 2156409 Positive_regulation RASSF10 PRKAR1B 23552700 2156410 Positive_regulation RASSF10 PRKAR1B 23552700 2156424 Positive_regulation RASSF10 PRKAR2A 23552700 2156383 Positive_regulation RASSF10 PRKAR2A 23552700 2156401 Positive_regulation RASSF10 PRKAR2A 23552700 2156411 Positive_regulation RASSF10 PRKAR2A 23552700 2156412 Positive_regulation RASSF10 PRKAR2A 23552700 2156425 Positive_regulation RASSF10 PRKAR2B 23552700 2156384 Positive_regulation RASSF10 PRKAR2B 23552700 2156402 Positive_regulation RASSF10 PRKAR2B 23552700 2156413 Positive_regulation RASSF10 PRKAR2B 23552700 2156414 Positive_regulation RASSF10 PRKAR2B 23552700 2156426 Positive_regulation RB1 CCND1 10682682 416342 Positive_regulation RB1 CCND1 11161387 418293 Positive_regulation RB1 CCND1 14612904 423759 Positive_regulation RB1 CCND1 19863813 584402 Positive_regulation RB1 CCND1 20113529 1853288 Positive_regulation RB1 CCND1 20540739 256222 Positive_regulation RB1 CCND1 20721988 774932 Positive_regulation RB1 CCND1 21347341 3051196 Positive_regulation RB1 CCND1 21368870 550819 Positive_regulation RB1 CCND1 21483670 2511777 Positive_regulation RB1 CCND1 23259795 1699220 Positive_regulation RB1 CCND1 23383271 2749828 Positive_regulation RB1 CCND1 24146910 2868234 Positive_regulation RB1 CCND1 24876129 758425 Positive_regulation RB1 CCND1 24987693 193657 Positive_regulation RB1 CCND1 PMC3300864 477144 Positive_regulation RB1 CTGF 25003330 2195006 Positive_regulation RB1 EPHB2 24330646 412497 Positive_regulation RB1 MAP2K6 22531632 438591 Positive_regulation RB1 PECAM1 24548763 809526 Positive_regulation RB1 PIGR 24699841 1886377 Positive_regulation RBBP4 EPHB2 16262446 2258791 Positive_regulation RBBP4 ETV7 22291956 2591500 Positive_regulation RBBP4 NES 24552625 2013170 Positive_regulation RBBP4 TNF 21234331 1218433 Positive_regulation RBBP4 TNF 24707477 188397 Positive_regulation RBBP4 TNF 24707477 188398 Positive_regulation RBBP4 TNF 7931061 1593068 Positive_regulation RBBP4 ZFP57 20808772 2472199 Positive_regulation RBBP7 EPHB2 16262446 2258792 Positive_regulation RBBP7 NES 24552625 2013179 Positive_regulation RBBP7 TNF 21234331 1218435 Positive_regulation RBBP7 TNF 24707477 188399 Positive_regulation RBBP7 TNF 24707477 188400 Positive_regulation RBBP7 TNF 7931061 1593070 Positive_regulation RBBP7 ZFP57 20808772 2472217 Positive_regulation RBFOX3 FOXO1 22555369 14813 Positive_regulation RBFOX3 TLR7 24740015 2953836 Positive_regulation RBFOX3 TLR7 24740015 2954357 Positive_regulation RBL1 CCND1 21283765 2498090 Positive_regulation RBL1 EPHB2 23829771 410460 Positive_regulation RBL1 FAS 12923319 1634161 Positive_regulation RBL2 CCND1 21283765 2498092 Positive_regulation RBL2 IFI27 22417103 587257 Positive_regulation RBM10 TNF 21799736 2538402 Positive_regulation RBM5 MIP 23147374 808702 Positive_regulation RBM5 TNF 20652022 2456175 Positive_regulation RBM5 TNF 22125644 2573865 Positive_regulation RBM5 TP63 22102818 3054755 Positive_regulation RBMS1 IFI27 22507221 624829 Positive_regulation RBMS1 TLR7 20539755 2452432 Positive_regulation RBP4 FOXO1 21804540 1961584 Positive_regulation RBP4 TNF 19597296 736297 Positive_regulation RBP4 TNF 19597296 736301 Positive_regulation RBP4 TNF 22272381 1082518 Positive_regulation RBPJ HES2 23695674 1936725 Positive_regulation RBPJ MAML3 17998388 1547722 Positive_regulation RBPJ TNF 22249448 1566863 Positive_regulation RCAN1 APP 24086147 2351283 Positive_regulation RCAN1 CA2 19725972 1646639 Positive_regulation RCAN1 CA2 19725972 1646660 Positive_regulation RCAN1 CA2 22461792 680252 Positive_regulation RCAN1 CREB1 25144594 3001106 Positive_regulation RCAN1 CREB3 25144594 3001107 Positive_regulation RCAN1 CREB5 25144594 3001105 Positive_regulation RCAN1 EGR1 19124655 1553339 Positive_regulation RCAN1 EGR1 19124655 1553340 Positive_regulation RCAN1 EGR1 19124655 1553341 Positive_regulation RCAN1 EGR1 19124655 1553468 Positive_regulation RCAN1 HDAC3 25144594 3001074 Positive_regulation RCAN1 HDAC3 25144594 3001075 Positive_regulation RCAN1 HDAC3 25144594 3001082 Positive_regulation RCAN1 HDAC3 25144594 3001098 Positive_regulation RCAN1 HDAC3 25144594 3001102 Positive_regulation RCAN1 HDAC3 25144594 3001103 Positive_regulation RCAN1 HDAC3 25144594 3001108 Positive_regulation RCAN1 IL1A 22397398 1661325 Positive_regulation RCAN1 KRT15 23028325 3059431 Positive_regulation RCAN1 NEDD8 23118980 2712384 Positive_regulation RCAN1 NEDD8 23118980 2712394 Positive_regulation RCAN1 NEDD8 23118980 2712403 Positive_regulation RCAN1 NEDD8 23118980 2712406 Positive_regulation RCAN1 NFATC1 19348862 158364 Positive_regulation RCAN1 NGF 23825664 2809926 Positive_regulation RCAN1 NGF 23825664 2809927 Positive_regulation RCAN1 PGF 19819266 158535 Positive_regulation RCAN1 PGF 19819266 158559 Positive_regulation RCAN1 PGF 19819266 158560 Positive_regulation RCAN1 PGF 19819266 158577 Positive_regulation RCAN1 PPP3CA 19725972 1646662 Positive_regulation RCAN1 PPP3CA 19725972 1646674 Positive_regulation RCAN1 PPP3CA 19725972 1646678 Positive_regulation RCAN1 PPP3CA 20625401 2454990 Positive_regulation RCAN1 PPP3CA 22461792 680253 Positive_regulation RCAN1 PPP3CA 25009690 2229546 Positive_regulation RCAN1 PPP3CB 19725972 1646663 Positive_regulation RCAN1 PPP3CB 19725972 1646679 Positive_regulation RCAN1 PPP3CB 20625401 2454991 Positive_regulation RCAN1 PPP3CB 25009690 2229547 Positive_regulation RCAN1 PPP3CC 19725972 1646664 Positive_regulation RCAN1 PPP3CC 19725972 1646680 Positive_regulation RCAN1 PPP3CC 20625401 2454992 Positive_regulation RCAN1 PPP3CC 25009690 2229548 Positive_regulation RCAN1 PPP3R1 19725972 1646675 Positive_regulation RCAN1 PPP3R1 19725972 1646681 Positive_regulation RCAN1 PPP3R1 22461792 680254 Positive_regulation RCAN1 PRKACB 22848844 2002924 Positive_regulation RCAN1 PRKACG 22848844 2002925 Positive_regulation RCAN1 PRKAR1A 22848844 2002926 Positive_regulation RCAN1 PRKAR1B 22848844 2002927 Positive_regulation RCAN1 PRKAR2A 22848844 2002928 Positive_regulation RCAN1 PRKAR2B 22848844 2002929 Positive_regulation RCAN1 PROK1 19348862 158318 Positive_regulation RCAN1 PROK1 19348862 158319 Positive_regulation RCAN1 PROK1 19348862 158320 Positive_regulation RCAN1 PROK1 19348862 158352 Positive_regulation RCAN1 PROK1 19348862 158353 Positive_regulation RCAN1 PROK1 19348862 158356 Positive_regulation RCAN1 PROK1 19348862 158357 Positive_regulation RCAN1 PROK1 19801577 1885315 Positive_regulation RCAN1 RIT1 24751678 2956076 Positive_regulation RCAN1 SDC4 22164265 2580211 Positive_regulation RCAN1 TAC1 23011132 1934377 Positive_regulation RCAN1 TAC3 23011132 1934378 Positive_regulation RCAN1 TAC4 23011132 1934379 Positive_regulation RCAN1 TNF 21496308 1036383 Positive_regulation RCAN1 TNP1 19124655 1553483 Positive_regulation RCAN1 TNP1 19124655 1553487 Positive_regulation RCAN1 TNP2 19124655 1553484 Positive_regulation RCAN1 TNP2 19124655 1553488 Positive_regulation RCAN1 UGCG 19725972 1646638 Positive_regulation RCAN1 VEGFA 20625401 2454978 Positive_regulation RCAN1 VEGFA 20625401 2454979 Positive_regulation RCAN1 VEGFA 20625401 2454980 Positive_regulation RCAN1 VEGFA 20625401 2454987 Positive_regulation RCAN1 VEGFA 20625401 2454988 Positive_regulation RCAN1 VEGFA 20625401 2454989 Positive_regulation RCAN1 VEGFA 20625401 2455003 Positive_regulation RCAN1 VEGFA 20625401 2455006 Positive_regulation RCAN1 VEGFA 21496308 1036384 Positive_regulation RCOR1 PGC 22453831 1933602 Positive_regulation RCOR3 PGC 22453831 1933606 Positive_regulation RDX TSPAN1 21961047 2557541 Positive_regulation RECQL4 CCND1 21951911 482306 Positive_regulation RECQL4 TNF 21779319 2536665 Positive_regulation REG1A CTGF 24058910 184115 Positive_regulation REG1A EPHB2 22312430 2595163 Positive_regulation REG1A TLR7 25349560 1147400 Positive_regulation REG3A EPHB2 18084034 2032235 Positive_regulation REG3A EPHB2 18084034 2032273 Positive_regulation REG3A TNF 16700916 312916 Positive_regulation REG3A TNF 24587207 2929048 Positive_regulation REL EPHB2 15606917 1734103 Positive_regulation REL EPHB2 20802521 2135475 Positive_regulation REL EPHB2 20802521 2135514 Positive_regulation REL FOXO1 24380076 864739 Positive_regulation REL JAG1 22166355 1234873 Positive_regulation REL TLR7 24098413 2856172 Positive_regulation REL TNF 16191192 318562 Positive_regulation REL TNF 16191192 318598 Positive_regulation REL TNF 23071583 2703028 Positive_regulation REL TNF 24024170 3093421 Positive_regulation REL TNF 24024170 3093435 Positive_regulation REL TNF 24024170 3093438 Positive_regulation REL TNF 24024170 3093442 Positive_regulation RELA CD14 23342367 3222081 Positive_regulation RELA EPHB2 22876248 903055 Positive_regulation RELA EPHB2 23555655 2774730 Positive_regulation RELA EPHB2 24453421 1756788 Positive_regulation RELA FAS 25392688 490140 Positive_regulation RELA ID1 23714001 1699835 Positive_regulation RELA IL1B 12745547 1738460 Positive_regulation RELA IL1B 12745547 1738461 Positive_regulation RELA IL1B 12745547 1738462 Positive_regulation RELA IL1B 12745547 1738463 Positive_regulation RELA IL1B 12745547 1738464 Positive_regulation RELA IL1B 12745547 1738465 Positive_regulation RELA IL1B 12745547 1738466 Positive_regulation RELA IL1B 12745547 1738467 Positive_regulation RELA IL1B 12745547 1738468 Positive_regulation RELA IL1B 12745547 1738469 Positive_regulation RELA IL1B 12745547 1738470 Positive_regulation RELA IL1B 12745547 1738480 Positive_regulation RELA IL1B 12745547 1738481 Positive_regulation RELA IL1B 15203568 1739691 Positive_regulation RELA IL1B 18472873 1742430 Positive_regulation RELA IL1B 20426870 3098286 Positive_regulation RELA IL1B 21206541 3175183 Positive_regulation RELA IL1B 25436109 1161837 Positive_regulation RELA ITGB2 22110533 633561 Positive_regulation RELA JAG1 22166355 1234874 Positive_regulation RELA MAP2K6 16491824 1710991 Positive_regulation RELA MAP2K6 23675062 1064456 Positive_regulation RELA MAP2K6 23675062 1064457 Positive_regulation RELA MIP 9788893 798126 Positive_regulation RELA MMP28 15770046 1739910 Positive_regulation RELA MMP28 22570691 2631272 Positive_regulation RELA MMP7 15770046 1739925 Positive_regulation RELA MMP7 22570691 2631287 Positive_regulation RELA SPHK1 20634980 2455692 Positive_regulation RELA SPHK1 20634980 2455775 Positive_regulation RELA SPHK1 20634980 2455788 Positive_regulation RELA STAT4 22969750 877125 Positive_regulation RELA TLR7 17534423 2376188 Positive_regulation RELA TLR7 19966777 1960898 Positive_regulation RELA TLR7 20230632 3213081 Positive_regulation RELA TLR7 20230632 3213114 Positive_regulation RELA TLR7 21750679 2325156 Positive_regulation RELA TLR7 22052242 984367 Positive_regulation RELA TLR7 22242189 2587419 Positive_regulation RELA TLR7 23024779 2689793 Positive_regulation RELA TLR7 23305364 694070 Positive_regulation RELA TLR7 23521892 3215408 Positive_regulation RELA TLR7 24098413 2856182 Positive_regulation RELA TLR7 24454965 2910524 Positive_regulation RELA TLR7 25117662 2996798 Positive_regulation RELA TLR7 25117662 2996922 Positive_regulation RELA TLR7 25429285 881407 Positive_regulation RELA TLR7 PMC2756345 495809 Positive_regulation RELA TLR7 PMC3953183 2236299 Positive_regulation RELA TM4SF19 25344917 2206240 Positive_regulation RELA TNF 10075983 1511261 Positive_regulation RELA TNF 10704075 1736862 Positive_regulation RELA TNF 11097206 702062 Positive_regulation RELA TNF 12003644 312738 Positive_regulation RELA TNF 12003644 312743 Positive_regulation RELA TNF 12745546 1738357 Positive_regulation RELA TNF 1314883 1528385 Positive_regulation RELA TNF 1314883 1528389 Positive_regulation RELA TNF 1314883 1528393 Positive_regulation RELA TNF 1314883 1528395 Positive_regulation RELA TNF 15694007 391925 Positive_regulation RELA TNF 15857511 648865 Positive_regulation RELA TNF 16191192 318599 Positive_regulation RELA TNF 16551357 3096207 Positive_regulation RELA TNF 17032459 319206 Positive_regulation RELA TNF 1740663 1545103 Positive_regulation RELA TNF 17480215 1225743 Positive_regulation RELA TNF 17592646 250178 Positive_regulation RELA TNF 18078008 3208463 Positive_regulation RELA TNF 18334025 1003661 Positive_regulation RELA TNF 18450815 2034437 Positive_regulation RELA TNF 18472824 1741861 Positive_regulation RELA TNF 18472824 1741867 Positive_regulation RELA TNF 18472873 1742429 Positive_regulation RELA TNF 18553155 3090028 Positive_regulation RELA TNF 19060883 1983094 Positive_regulation RELA TNF 19132086 3042915 Positive_regulation RELA TNF 20126546 2439179 Positive_regulation RELA TNF 20145703 1213514 Positive_regulation RELA TNF 20150970 1213784 Positive_regulation RELA TNF 20181085 2236005 Positive_regulation RELA TNF 20300540 1747130 Positive_regulation RELA TNF 20386714 3046571 Positive_regulation RELA TNF 20844082 1782659 Positive_regulation RELA TNF 20948609 846232 Positive_regulation RELA TNF 21108843 3213395 Positive_regulation RELA TNF 21131967 1954742 Positive_regulation RELA TNF 21131967 1954748 Positive_regulation RELA TNF 21298084 2321015 Positive_regulation RELA TNF 21324111 121473 Positive_regulation RELA TNF 21324111 121474 Positive_regulation RELA TNF 21324111 121477 Positive_regulation RELA TNF 21324111 121500 Positive_regulation RELA TNF 21342546 238018 Positive_regulation RELA TNF 21451502 1918280 Positive_regulation RELA TNF 21492465 360643 Positive_regulation RELA TNF 21539730 1626370 Positive_regulation RELA TNF 21569464 1697267 Positive_regulation RELA TNF 21593200 719218 Positive_regulation RELA TNF 21622953 2063353 Positive_regulation RELA TNF 21629653 2525311 Positive_regulation RELA TNF 21706061 2140617 Positive_regulation RELA TNF 21706061 2140623 Positive_regulation RELA TNF 21738489 2325081 Positive_regulation RELA TNF 21765477 2141235 Positive_regulation RELA TNF 21765477 2141236 Positive_regulation RELA TNF 21765477 2141237 Positive_regulation RELA TNF 21765477 2141249 Positive_regulation RELA TNF 21765477 2141258 Positive_regulation RELA TNF 21765477 2141276 Positive_regulation RELA TNF 21765477 2141284 Positive_regulation RELA TNF 21799681 812964 Positive_regulation RELA TNF 21808651 633117 Positive_regulation RELA TNF 21810263 1659152 Positive_regulation RELA TNF 21810263 1659162 Positive_regulation RELA TNF 21838863 3214288 Positive_regulation RELA TNF 21853090 2543188 Positive_regulation RELA TNF 21857970 2544488 Positive_regulation RELA TNF 21857970 2544492 Positive_regulation RELA TNF 21912593 2552138 Positive_regulation RELA TNF 21912593 2552140 Positive_regulation RELA TNF 21912646 2552483 Positive_regulation RELA TNF 21912646 2552495 Positive_regulation RELA TNF 21992116 1697921 Positive_regulation RELA TNF 21992116 1697922 Positive_regulation RELA TNF 22046242 2566195 Positive_regulation RELA TNF 22046242 2566199 Positive_regulation RELA TNF 22046242 2566205 Positive_regulation RELA TNF 22052242 984366 Positive_regulation RELA TNF 22096400 1030536 Positive_regulation RELA TNF 22189739 652969 Positive_regulation RELA TNF 22393382 2608053 Positive_regulation RELA TNF 22406746 1962261 Positive_regulation RELA TNF 22472082 1049158 Positive_regulation RELA TNF 22654792 875817 Positive_regulation RELA TNF 22654792 875818 Positive_regulation RELA TNF 22654792 875830 Positive_regulation RELA TNF 22654792 875835 Positive_regulation RELA TNF 22672528 482513 Positive_regulation RELA TNF 22672528 482519 Positive_regulation RELA TNF 22720084 2654436 Positive_regulation RELA TNF 22880094 2674216 Positive_regulation RELA TNF 22891766 245233 Positive_regulation RELA TNF 22911724 2675977 Positive_regulation RELA TNF 22911724 2675980 Positive_regulation RELA TNF 22911724 2675983 Positive_regulation RELA TNF 22911724 2675992 Positive_regulation RELA TNF 22970172 2687439 Positive_regulation RELA TNF 22970172 2687445 Positive_regulation RELA TNF 22973447 2688243 Positive_regulation RELA TNF 22996371 1029317 Positive_regulation RELA TNF 22996371 1029318 Positive_regulation RELA TNF 22996371 1029329 Positive_regulation RELA TNF 22996371 1029330 Positive_regulation RELA TNF 22996371 1029331 Positive_regulation RELA TNF 23109839 1098350 Positive_regulation RELA TNF 23125866 637090 Positive_regulation RELA TNF 23130241 1043816 Positive_regulation RELA TNF 23168575 2235791 Positive_regulation RELA TNF 23271966 3060157 Positive_regulation RELA TNF 23272249 2730245 Positive_regulation RELA TNF 23272249 2730247 Positive_regulation RELA TNF 23299785 3222047 Positive_regulation RELA TNF 23300756 2735922 Positive_regulation RELA TNF 23381555 1140574 Positive_regulation RELA TNF 23424624 2755013 Positive_regulation RELA TNF 23576877 1628492 Positive_regulation RELA TNF 23576877 1628495 Positive_regulation RELA TNF 23576877 1628498 Positive_regulation RELA TNF 23576877 1628502 Positive_regulation RELA TNF 23593011 2345146 Positive_regulation RELA TNF 23593011 2345172 Positive_regulation RELA TNF 23593011 2345209 Positive_regulation RELA TNF 23634661 1666612 Positive_regulation RELA TNF 23651618 3085077 Positive_regulation RELA TNF 23762160 820147 Positive_regulation RELA TNF 24004852 803466 Positive_regulation RELA TNF 24083153 1053922 Positive_regulation RELA TNF 24193319 3138598 Positive_regulation RELA TNF 24212623 497850 Positive_regulation RELA TNF 24212647 497903 Positive_regulation RELA TNF 24318359 2186079 Positive_regulation RELA TNF 24330637 1703406 Positive_regulation RELA TNF 24330732 1870537 Positive_regulation RELA TNF 24428943 1701212 Positive_regulation RELA TNF 24453421 1756964 Positive_regulation RELA TNF 24580844 411063 Positive_regulation RELA TNF 24587411 2929897 Positive_regulation RELA TNF 24587411 2929901 Positive_regulation RELA TNF 24596622 206186 Positive_regulation RELA TNF 24611099 2115399 Positive_regulation RELA TNF 24642040 474550 Positive_regulation RELA TNF 24714696 2950159 Positive_regulation RELA TNF 24740421 2954833 Positive_regulation RELA TNF 24822058 1703412 Positive_regulation RELA TNF 24824433 2969214 Positive_regulation RELA TNF 24860732 1694781 Positive_regulation RELA TNF 24876878 825966 Positive_regulation RELA TNF 24957606 2102182 Positive_regulation RELA TNF 24957606 2102190 Positive_regulation RELA TNF 24957606 2102194 Positive_regulation RELA TNF 24957606 2102196 Positive_regulation RELA TNF 24983623 2985731 Positive_regulation RELA TNF 25015002 357677 Positive_regulation RELA TNF 25074812 1488223 Positive_regulation RELA TNF 25076912 965645 Positive_regulation RELA TNF 25119989 2997188 Positive_regulation RELA TNF 25152758 826754 Positive_regulation RELA TNF 25152758 826793 Positive_regulation RELA TNF 25202711 1623186 Positive_regulation RELA TNF 25250048 896988 Positive_regulation RELA TNF 25443632 762682 Positive_regulation RELA TNF 25443632 762701 Positive_regulation RELA TNF 25443632 762706 Positive_regulation RELA TNF 25443632 762714 Positive_regulation RELA TNF 25443632 762719 Positive_regulation RELA TNF 7523573 1589602 Positive_regulation RELA TNF 7629516 1591295 Positive_regulation RELA TNF 7931065 1593161 Positive_regulation RELA TNF 8027185 1444190 Positive_regulation RELA TNF 8027185 1444191 Positive_regulation RELA TNF 8386742 1595097 Positive_regulation RELA TNF 8647884 1451560 Positive_regulation RELA TNF 8647884 1451564 Positive_regulation RELA TNF 8647884 1451599 Positive_regulation RELA TNF 8647884 1451604 Positive_regulation RELA TNF 8655581 1451880 Positive_regulation RELA TNF 8655581 1451905 Positive_regulation RELA TNF 8666909 1597107 Positive_regulation RELA TNF 8691131 1598174 Positive_regulation RELA TNF 8691131 1598175 Positive_regulation RELA TNF 8691131 1598218 Positive_regulation RELA TNF 8691131 1598231 Positive_regulation RELA TNF 8691131 1598232 Positive_regulation RELA TNF 8698809 1452457 Positive_regulation RELA TNF 8698809 1452480 Positive_regulation RELA TNF 8698809 1452481 Positive_regulation RELA TNF 8698809 1452482 Positive_regulation RELA TNF 8760826 1598987 Positive_regulation RELA TNF 8894979 1612767 Positive_regulation RELA TNF 9400742 797550 Positive_regulation RELA TNF PMC2364207 449971 Positive_regulation RELA TNF PMC2750202 450202 Positive_regulation RELA TNF PMC3332443 134779 Positive_regulation RELA TNF PMC3953183 2236298 Positive_regulation RELA TNF PMC4070603 3206069 Positive_regulation RELA TNF PMC4212306 3206367 Positive_regulation RELA TNFSF10 15916713 248767 Positive_regulation RELA TNFSF10 19895686 254585 Positive_regulation RELA TNFSF10 21756247 3093064 Positive_regulation RELA TNFSF10 22672528 482524 Positive_regulation RELA TNFSF10 24130833 2867297 Positive_regulation RELB TLR7 23086447 1957947 Positive_regulation RELB TNF 21451502 1918394 Positive_regulation RELB TNF 22880094 2674200 Positive_regulation RELB TNF PMC2834068 134558 Positive_regulation RELN ADAMTS1 24176075 1667246 Positive_regulation RELN EPHB2 23318582 610962 Positive_regulation RELN EPHB2 23318582 610963 Positive_regulation RELN EPHB2 23318582 611008 Positive_regulation RELN EPHB2 23318582 611020 Positive_regulation RELN EPHB2 23318582 611051 Positive_regulation RELN PCDH19 16847104 1331334 Positive_regulation RELN PCDH8 16847104 1331339 Positive_regulation REN RASD1 21247419 376236 Positive_regulation REN RASD1 21247419 376263 Positive_regulation REN RASD1 21247419 376277 Positive_regulation REN TNF 22518191 1143849 Positive_regulation RENBP FOXO1 20300563 1910605 Positive_regulation RENBP TNF 17183656 2373695 Positive_regulation RENBP TNF 24876878 825956 Positive_regulation RENBP TNF 25025559 1162116 Positive_regulation REST EPHB2 22675627 1688649 Positive_regulation RET EPHB2 20386724 2271420 Positive_regulation RET EPHB2 23527856 220402 Positive_regulation RET EPHB2 25076890 515695 Positive_regulation RET FOXO1 22529334 30614 Positive_regulation RET FOXO1 25254335 3167422 Positive_regulation RET MAP2K6 25076890 515701 Positive_regulation RETN EPHB2 21655142 1075756 Positive_regulation RETN TNF 19473519 1227119 Positive_regulation RETN TNF 19473519 1227120 Positive_regulation RETN TNF 19473519 1227121 Positive_regulation RETN TNF 19473519 1227122 Positive_regulation RETN TNF 19473519 1227123 Positive_regulation RETN TNF 19473519 1227124 Positive_regulation RETN TNF 19473519 1227125 Positive_regulation RETN TNF 19473519 1227126 Positive_regulation RETN TNF 19473519 1227127 Positive_regulation RETN TNF 19473519 1227131 Positive_regulation RETN TNF 19473519 1227132 Positive_regulation RETN TNF 19473519 1227133 Positive_regulation RETN TNF 19473519 1227137 Positive_regulation RETN TNF 19473519 1227138 Positive_regulation RETN TNF 19473519 1227139 Positive_regulation RETN TNF 19473519 1227141 Positive_regulation RETN TNF 19473519 1227143 Positive_regulation RETN TNF 19473519 1227145 Positive_regulation RETN TNF 19473519 1227146 Positive_regulation RETN TNF 19473519 1227148 Positive_regulation RETN TNF 19473519 1227152 Positive_regulation RETN TNF 19473519 1227153 Positive_regulation RETN TNF 19473519 1227154 Positive_regulation RETN TNF 19473519 1227155 Positive_regulation RETN TNF 19473519 1227157 Positive_regulation RETN TNF 22577247 1749881 Positive_regulation RETN TNF 22577940 125866 Positive_regulation RETN TNF 22935594 30827 Positive_regulation RETN TNF 23304125 980600 Positive_regulation RETN TNF 23843680 1753844 Positive_regulation RETN TNF 24404511 731051 Positive_regulation RETN TNF 24799765 1758383 Positive_regulation RGMA UNC5B 25374504 939317 Positive_regulation RGS16 AKT1 25568667 987499 Positive_regulation RGS16 AKT2 25568667 987500 Positive_regulation RGS16 AKT3 25568667 987501 Positive_regulation RGS16 RB1 25568667 987488 Positive_regulation RGS16 SRC 16638134 249352 Positive_regulation RGS16 TP53 25568667 987487 Positive_regulation RGS19 TNF 24751948 2956182 Positive_regulation RGS2 ADCY5 25077541 577820 Positive_regulation RGS2 C5 21829669 2542257 Positive_regulation RGS2 CCL2 21494556 2513022 Positive_regulation RGS2 F2R 24743392 2955420 Positive_regulation RGS2 MYLIP 25077541 577831 Positive_regulation RGS2 NPAS4 23656887 727278 Positive_regulation RGS2 NPAS4 23656887 727279 Positive_regulation RGS2 NPAS4 23656887 727304 Positive_regulation RGS2 NPPA 20352235 142248 Positive_regulation RGS2 NPPA 20352235 142257 Positive_regulation RGS2 NPPA 20352235 142258 Positive_regulation RGS2 NPPA 20352235 142266 Positive_regulation RGS2 NPPA 20352235 142267 Positive_regulation RGS2 NPPA 20352235 142276 Positive_regulation RGS2 NPPA 20352235 142278 Positive_regulation RGS2 TAC1 22802950 2663752 Positive_regulation RGS2 TAC3 22802950 2663753 Positive_regulation RGS2 TAC4 22802950 2663754 Positive_regulation RGS4 EPHB2 22253691 2587581 Positive_regulation RGS4 MAP2K6 22545125 2623823 Positive_regulation RGS7 TNF 21698121 2530422 Positive_regulation RHEB EPHB2 24391850 2904747 Positive_regulation RHEB EPHB2 24391850 2904748 Positive_regulation RHEB EPHB2 24391850 2904756 Positive_regulation RHO CAPN8 11062268 1264814 Positive_regulation RHO CAPN8 PMC2185599 1475242 Positive_regulation RHO EPHB2 21390298 2274364 Positive_regulation RHO EPHB2 23986484 1487083 Positive_regulation RHO EPHB2 25121106 196635 Positive_regulation RHO F2R 21591259 776166 Positive_regulation RHO F2R 21591259 776167 Positive_regulation RHO F2R 21591259 776168 Positive_regulation RHO F2R 21591259 776194 Positive_regulation RHO F2R 24743392 2955259 Positive_regulation RHO F2R 24743392 2955267 Positive_regulation RHO ID1 24760515 2251971 Positive_regulation RHO S1PR3 21304987 2502047 Positive_regulation RHO SLC6A2 23864709 1817035 Positive_regulation RHOA ANGPT1 23253477 1401584 Positive_regulation RHOA CTGF 20858895 1188522 Positive_regulation RHOA CTGF 20858895 1188527 Positive_regulation RHOA EFNB1 24868497 3179263 Positive_regulation RHOA EPHB2 19737544 154057 Positive_regulation RHOA EPHB2 20858895 1188528 Positive_regulation RHOA EPHB2 23251606 2729167 Positive_regulation RHOA EPHB2 23389627 1811800 Positive_regulation RHOA EPHB2 23389627 1811918 Positive_regulation RHOA EPHB2 24478700 858787 Positive_regulation RHOA F2R 23825105 2809483 Positive_regulation RHOA F2R 24058811 1706428 Positive_regulation RHOA F2R 24743392 2955397 Positive_regulation RHOA F2R 24743392 2955481 Positive_regulation RHOA FOXO1 25330112 3017207 Positive_regulation RHOA IFI27 20485671 2450706 Positive_regulation RHOA KANK4 18458160 1352013 Positive_regulation RHOA KANK4 18458160 1352101 Positive_regulation RHOA PGC 23728423 1929106 Positive_regulation RHOA PLAU 21858203 2546881 Positive_regulation RHOA PLAU 21858203 2546882 Positive_regulation RHOA PLAU 21858203 2546883 Positive_regulation RHOA PLAU 21858203 2546886 Positive_regulation RHOA PODXL 19889841 1770853 Positive_regulation RHOA PODXL 23677246 1709334 Positive_regulation RHOA RGS16 25568667 987494 Positive_regulation RHOA S1PR3 20089836 1773292 Positive_regulation RHOA SLC6A2 18509476 2389885 Positive_regulation RHOA SLC6A2 18509476 2389893 Positive_regulation RHOA SLC6A2 21390328 2506445 Positive_regulation RHOA SLC6A2 21390328 2506460 Positive_regulation RHOA SLC6A2 22069704 3183540 Positive_regulation RHOA SRGN 18086913 1346860 Positive_regulation RHOA SRGN 18086913 1346861 Positive_regulation RHOA TNF 21473788 1658056 Positive_regulation RHOA TNF 21473788 1658057 Positive_regulation RHOA TNF 21473788 1658058 Positive_regulation RHOA TNF 21473788 1658063 Positive_regulation RHOA TNF 21473788 1658064 Positive_regulation RHOA TNF 21473788 1658066 Positive_regulation RHOA TNF 21473788 1658071 Positive_regulation RHOA TNF 21473788 1658072 Positive_regulation RHOA TNF 21473788 1658077 Positive_regulation RHOA TNF 21473788 1658078 Positive_regulation RHOA TNF 21473788 1658079 Positive_regulation RHOA TNF 23365678 2745519 Positive_regulation RHOA TNF 23389627 1811797 Positive_regulation RHOA TNF 23389627 1811851 Positive_regulation RHOA TNF 23389627 1811886 Positive_regulation RHOA UNC5B 19273616 1364444 Positive_regulation RHOA UNC5B 19273616 1364445 Positive_regulation RHOA UNC5B 19273616 1364446 Positive_regulation RHOA UNC5B 19273616 1364514 Positive_regulation RHOA VSNL1 22479362 2614940 Positive_regulation RIC3 OPN1LW 15824136 1319930 Positive_regulation RIC3 OPN1LW 15824136 1319950 Positive_regulation RIC3 OPN1LW 15824136 1319954 Positive_regulation RICTOR FOXO1 23875175 945963 Positive_regulation RICTOR TLR7 24740015 2954026 Positive_regulation RING1 ZFP57 20808772 2471907 Positive_regulation RING1 ZFP57 20808772 2471980 Positive_regulation RINL EPHA8 22291991 2591638 Positive_regulation RINL RAB22A 22291991 2591631 Positive_regulation RINL RAB5A 22291991 2591632 Positive_regulation RIPK1 TNF 23301705 1479245 Positive_regulation RIPK1 TNF 23328672 558993 Positive_regulation RIPK1 TNF 23328672 559032 Positive_regulation RIPK1 TNF 23429285 559987 Positive_regulation RIPK1 TNF 24577082 572419 Positive_regulation RIPK1 TNF 24949464 192749 Positive_regulation RIPK1 TNFSF10 23301705 1479246 Positive_regulation RIPK2 TNF 22203860 633901 Positive_regulation RIPK3 EPHB2 25352744 1917358 Positive_regulation RIPK3 EPHB2 25352744 1917360 Positive_regulation RIPK3 FAS 21423395 955217 Positive_regulation RIPK3 FAS 24336086 570498 Positive_regulation RIPK3 TNF 23301705 1479247 Positive_regulation RIPK3 TNF 23328672 558995 Positive_regulation RIPK3 TNF 23328672 558996 Positive_regulation RIPK3 TNF 23328672 558997 Positive_regulation RIPK3 TNF 23328672 558998 Positive_regulation RIPK3 TNF 23328672 559019 Positive_regulation RIPK3 TNF 23760205 605923 Positive_regulation RIPK3 TNF 23835476 611273 Positive_regulation RIPK3 TNF 24090154 537726 Positive_regulation RIPK3 TNF 24098568 2858186 Positive_regulation RIPK3 TNF 24314238 270804 Positive_regulation RIPK3 TNF 24328763 451536 Positive_regulation RIPK3 TNF 24535827 1416603 Positive_regulation RIPK3 TNF 24751948 2956181 Positive_regulation RIPK3 TNF 24949464 192751 Positive_regulation RIPK3 TNF 24991764 576778 Positive_regulation RIPK3 TNFSF10 23301705 1479248 Positive_regulation RIT2 GPR132 22880057 2674114 Positive_regulation RLN1 EPHB2 22737225 2655646 Positive_regulation RLN2 EPHB2 22737225 2655655 Positive_regulation RLN3 EPHB2 22737225 2655664 Positive_regulation RNASE1 ACP1 6061722 1429548 Positive_regulation RNASE1 ACP2 6061722 1429549 Positive_regulation RNASE1 ACP5 6061722 1429550 Positive_regulation RNASE1 ACP6 6061722 1429551 Positive_regulation RNASE1 AOC1 25101113 896490 Positive_regulation RNASE1 CA2 8089168 1444538 Positive_regulation RNASE1 CCNT1 22379134 2073083 Positive_regulation RNASE1 CCNT2 22379134 2073084 Positive_regulation RNASE1 CDK9 22379134 2073085 Positive_regulation RNASE1 DROSHA 20660014 2056241 Positive_regulation RNASE1 DSCAM-AS1 22889300 3120377 Positive_regulation RNASE1 EED 24320048 157099 Positive_regulation RNASE1 ERN1 21729333 244144 Positive_regulation RNASE1 ERN1 21729334 244305 Positive_regulation RNASE1 ERN1 22174623 1091893 Positive_regulation RNASE1 ERN1 22737387 1674640 Positive_regulation RNASE1 ERN1 24688718 657051 Positive_regulation RNASE1 ERN1 25369058 3022158 Positive_regulation RNASE1 ERN1 25369058 3022170 Positive_regulation RNASE1 EXO1 20004735 1768480 Positive_regulation RNASE1 EXO5 20004735 1768479 Positive_regulation RNASE1 EZH2 24320048 157100 Positive_regulation RNASE1 GLI3 25101113 896489 Positive_regulation RNASE1 GRP 17169986 2024785 Positive_regulation RNASE1 JAG1 19015152 2037565 Positive_regulation RNASE1 KCNH4 20137095 375067 Positive_regulation RNASE1 KLHL24 19619322 310815 Positive_regulation RNASE1 MAP3K5 23990788 3063953 Positive_regulation RNASE1 MCOLN1 19814799 3212868 Positive_regulation RNASE1 MCOLN1 21738782 2533842 Positive_regulation RNASE1 MCOLN1 22561375 2075002 Positive_regulation RNASE1 MS4A2 23086298 1931742 Positive_regulation RNASE1 MS4A2 23086298 1931778 Positive_regulation RNASE1 OPN1MW 18828922 247649 Positive_regulation RNASE1 PCBD1 25101113 896575 Positive_regulation RNASE1 PCNA 21245041 2059755 Positive_regulation RNASE1 PCNA 21245041 2059756 Positive_regulation RNASE1 PCNA 21245041 2059757 Positive_regulation RNASE1 PCNA 21245041 2059840 Positive_regulation RNASE1 PCNA 21245041 2059852 Positive_regulation RNASE1 PCNA 21245041 2059853 Positive_regulation RNASE1 PCNA 21245041 2059938 Positive_regulation RNASE1 PCNA 21245041 2059988 Positive_regulation RNASE1 PCNA 23144626 2339552 Positive_regulation RNASE1 POLR2I 17179178 2025088 Positive_regulation RNASE1 POP1 21053045 599596 Positive_regulation RNASE1 POP5 22162665 97109 Positive_regulation RNASE1 PRPH2 21994660 3219577 Positive_regulation RNASE1 PRX 23949117 3136825 Positive_regulation RNASE1 RNASE1 18000552 2380976 Positive_regulation RNASE1 RNASE1 18000552 2380977 Positive_regulation RNASE1 RNASE10 18000552 2380988 Positive_regulation RNASE1 RNASE10 18000552 2380989 Positive_regulation RNASE1 RNASE11 18000552 2380986 Positive_regulation RNASE1 RNASE11 18000552 2380987 Positive_regulation RNASE1 RNASE12 18000552 2380996 Positive_regulation RNASE1 RNASE12 18000552 2380997 Positive_regulation RNASE1 RNASE13 18000552 2380998 Positive_regulation RNASE1 RNASE13 18000552 2380999 Positive_regulation RNASE1 RNASE2 18000552 2380978 Positive_regulation RNASE1 RNASE2 18000552 2380979 Positive_regulation RNASE1 RNASE3 18000552 2380980 Positive_regulation RNASE1 RNASE3 18000552 2380981 Positive_regulation RNASE1 RNASE4 18000552 2380982 Positive_regulation RNASE1 RNASE4 18000552 2380983 Positive_regulation RNASE1 RNASE6 18000552 2380984 Positive_regulation RNASE1 RNASE6 18000552 2380985 Positive_regulation RNASE1 RNASE7 18000552 2380992 Positive_regulation RNASE1 RNASE7 18000552 2380993 Positive_regulation RNASE1 RNASE8 18000552 2380990 Positive_regulation RNASE1 RNASE8 18000552 2380991 Positive_regulation RNASE1 RNASE9 18000552 2380994 Positive_regulation RNASE1 RNASE9 18000552 2380995 Positive_regulation RNASE1 RPL18 16077031 2017114 Positive_regulation RNASE1 RPP30 22162665 97108 Positive_regulation RNASE1 RPP40 21053045 599595 Positive_regulation RNASE1 RRBP1 23910895 3201999 Positive_regulation RNASE1 RRBP1 24239293 1878476 Positive_regulation RNASE1 RSL24D1 23777426 378328 Positive_regulation RNASE1 RTN4 22174690 3055198 Positive_regulation RNASE1 SDS 23737447 2089077 Positive_regulation RNASE1 TERT 16452301 2019376 Positive_regulation RNASE1 TERT 21053045 599630 Positive_regulation RNASE1 TNF 20089176 284033 Positive_regulation RNASE1 WRAP53 24659245 171520 Positive_regulation RNASE1 ZC3H12A 22561375 2074978 Positive_regulation RNASE10 JAG1 19015152 2037573 Positive_regulation RNASE10 TNF 20089176 284051 Positive_regulation RNASE11 JAG1 19015152 2037572 Positive_regulation RNASE11 TNF 20089176 284050 Positive_regulation RNASE12 JAG1 19015152 2037577 Positive_regulation RNASE12 TNF 20089176 284055 Positive_regulation RNASE13 JAG1 19015152 2037578 Positive_regulation RNASE13 TNF 20089176 284056 Positive_regulation RNASE2 JAG1 19015152 2037566 Positive_regulation RNASE2 TNF 20089176 284034 Positive_regulation RNASE3 JAG1 19015152 2037567 Positive_regulation RNASE3 MIP 1281207 1527715 Positive_regulation RNASE3 TNF 15857511 648853 Positive_regulation RNASE3 TNF 15857511 648857 Positive_regulation RNASE3 TNF 15857511 648866 Positive_regulation RNASE3 TNF 20089176 284035 Positive_regulation RNASE4 JAG1 19015152 2037568 Positive_regulation RNASE4 TNF 20089176 284036 Positive_regulation RNASE6 JAG1 19015152 2037569 Positive_regulation RNASE6 TNF 20089176 284037 Positive_regulation RNASE7 ACP1 6061722 1429580 Positive_regulation RNASE7 ACP2 6061722 1429581 Positive_regulation RNASE7 ACP5 6061722 1429582 Positive_regulation RNASE7 ACP6 6061722 1429583 Positive_regulation RNASE7 AOC1 25101113 896506 Positive_regulation RNASE7 DSCAM-AS1 22889300 3120385 Positive_regulation RNASE7 EGFR 24747887 2955893 Positive_regulation RNASE7 ERN1 21729333 244152 Positive_regulation RNASE7 ERN1 21729334 244313 Positive_regulation RNASE7 ERN1 22174623 1091901 Positive_regulation RNASE7 ERN1 22737387 1674648 Positive_regulation RNASE7 ERN1 24688718 657059 Positive_regulation RNASE7 ERN1 25369058 3022166 Positive_regulation RNASE7 ERN1 25369058 3022178 Positive_regulation RNASE7 EXO1 20004735 1768496 Positive_regulation RNASE7 EXO5 20004735 1768495 Positive_regulation RNASE7 GLI3 25101113 896505 Positive_regulation RNASE7 GRP 17169986 2024793 Positive_regulation RNASE7 IL17A 23555696 2774903 Positive_regulation RNASE7 IL17A 23555696 2774904 Positive_regulation RNASE7 IL17A 23555696 2774910 Positive_regulation RNASE7 IL17A 23555696 2774911 Positive_regulation RNASE7 IL17A 23555696 2774920 Positive_regulation RNASE7 IL17A 23555696 2774921 Positive_regulation RNASE7 IL17A 23555696 2774929 Positive_regulation RNASE7 IL17A 23555696 2774930 Positive_regulation RNASE7 IL17A 23555696 2774931 Positive_regulation RNASE7 IL17A 23555696 2774936 Positive_regulation RNASE7 IL17A 23555696 2774938 Positive_regulation RNASE7 IL17A 24747887 2955894 Positive_regulation RNASE7 IL17A 24747887 2955900 Positive_regulation RNASE7 IL17A 24747887 2955903 Positive_regulation RNASE7 IL17C 23555696 2774912 Positive_regulation RNASE7 JAG1 19015152 2037575 Positive_regulation RNASE7 KCNH4 20137095 375075 Positive_regulation RNASE7 KLHL24 19619322 310823 Positive_regulation RNASE7 MAP3K5 23990788 3063961 Positive_regulation RNASE7 MCOLN1 19814799 3212876 Positive_regulation RNASE7 MCOLN1 21738782 2533850 Positive_regulation RNASE7 MCOLN1 22561375 2075010 Positive_regulation RNASE7 MS4A2 23086298 1931750 Positive_regulation RNASE7 MS4A2 23086298 1931786 Positive_regulation RNASE7 MYLIP 23469087 2761398 Positive_regulation RNASE7 MYLIP 23469087 2761403 Positive_regulation RNASE7 MYLIP 23469087 2761409 Positive_regulation RNASE7 MYLIP 23469087 2761410 Positive_regulation RNASE7 PCBD1 25101113 896583 Positive_regulation RNASE7 PCNA 21245041 2059779 Positive_regulation RNASE7 PCNA 21245041 2059780 Positive_regulation RNASE7 PCNA 21245041 2059781 Positive_regulation RNASE7 PCNA 21245041 2059848 Positive_regulation RNASE7 PCNA 21245041 2059868 Positive_regulation RNASE7 PCNA 21245041 2059869 Positive_regulation RNASE7 PCNA 21245041 2059946 Positive_regulation RNASE7 PCNA 21245041 2059996 Positive_regulation RNASE7 PCNA 23144626 2339560 Positive_regulation RNASE7 POLR2I 17179178 2025096 Positive_regulation RNASE7 POP1 21053045 599612 Positive_regulation RNASE7 POP5 22162665 97125 Positive_regulation RNASE7 PRPH2 21994660 3219585 Positive_regulation RNASE7 RPL18 16077031 2017122 Positive_regulation RNASE7 RPP30 22162665 97124 Positive_regulation RNASE7 RPP40 21053045 599611 Positive_regulation RNASE7 RRBP1 23910895 3202007 Positive_regulation RNASE7 RRBP1 24239293 1878484 Positive_regulation RNASE7 RTN4 22174690 3055206 Positive_regulation RNASE7 STAT3 23555696 2774902 Positive_regulation RNASE7 STAT3 23555696 2774919 Positive_regulation RNASE7 STAT3 23555696 2774935 Positive_regulation RNASE7 TERT 16452301 2019384 Positive_regulation RNASE7 TERT 21053045 599638 Positive_regulation RNASE7 TNF 20089176 284053 Positive_regulation RNASE7 TNF 23555696 2774928 Positive_regulation RNASE7 TNF 23555696 2774937 Positive_regulation RNASE7 WRAP53 24659245 171528 Positive_regulation RNASE7 ZC3H12A 22561375 2074986 Positive_regulation RNASE8 JAG1 19015152 2037574 Positive_regulation RNASE8 TNF 20089176 284052 Positive_regulation RNASE9 JAG1 19015152 2037576 Positive_regulation RNASE9 TNF 20089176 284054 Positive_regulation RND3 EPHB2 23208503 2150219 Positive_regulation RND3 MAP2K6 23208503 2150225 Positive_regulation RNF10 TNF 22891766 245152 Positive_regulation RNF103 TNF 22891766 245164 Positive_regulation RNF11 TNF 22507528 1661600 Positive_regulation RNF11 TNF 22891766 245153 Positive_regulation RNF111 TNF 22891766 245176 Positive_regulation RNF112 TNF 22891766 245165 Positive_regulation RNF114 TNF 22891766 245166 Positive_regulation RNF115 TNF 22891766 245180 Positive_regulation RNF121 TNF 22891766 245187 Positive_regulation RNF122 TNF 22891766 245188 Positive_regulation RNF123 TNF 22891766 245189 Positive_regulation RNF125 TNF 22891766 245190 Positive_regulation RNF126 TNF 22891766 245191 Positive_regulation RNF128 TNF 22891766 245192 Positive_regulation RNF13 TNF 22891766 245154 Positive_regulation RNF130 TNF 22891766 245181 Positive_regulation RNF133 TNF 22891766 245193 Positive_regulation RNF135 TNF 22891766 245194 Positive_regulation RNF138 TNF 22891766 245177 Positive_regulation RNF139 TNF 22891766 245173 Positive_regulation RNF14 TNF 22891766 245155 Positive_regulation RNF141 TNF 22891766 245195 Positive_regulation RNF145 TNF 22891766 245186 Positive_regulation RNF146 TNF 22891766 245196 Positive_regulation RNF148 TNF 22891766 245199 Positive_regulation RNF149 TNF 22891766 245200 Positive_regulation RNF150 ASB4 24586788 2926763 Positive_regulation RNF150 CR1 21554755 1008115 Positive_regulation RNF150 CUL1 21554755 1008116 Positive_regulation RNF150 CUL2 21554755 1008117 Positive_regulation RNF150 CUL3 21554755 1008118 Positive_regulation RNF150 CUL5 21554755 1008119 Positive_regulation RNF150 CUL7 21554755 1008114 Positive_regulation RNF150 CUL9 21554755 1008113 Positive_regulation RNF150 TNF 22891766 245201 Positive_regulation RNF151 TNF 22891766 245202 Positive_regulation RNF152 TNF 22891766 245211 Positive_regulation RNF157 TNF 22891766 245221 Positive_regulation RNF165 TNF 22891766 245222 Positive_regulation RNF166 TNF 22891766 245220 Positive_regulation RNF167 TNF 22891766 245203 Positive_regulation RNF168 TNF 22891766 245209 Positive_regulation RNF169 TNF 22891766 245212 Positive_regulation RNF17 TNF 22891766 245156 Positive_regulation RNF170 TNF 22891766 245205 Positive_regulation RNF175 TNF 22891766 245215 Positive_regulation RNF180 TNF 22891766 245216 Positive_regulation RNF181 TNF 22891766 245217 Positive_regulation RNF182 TNF 22891766 245218 Positive_regulation RNF183 TNF 22891766 245219 Positive_regulation RNF185 TNF 22891766 245210 Positive_regulation RNF186 TNF 22891766 245208 Positive_regulation RNF187 TNF 22891766 245213 Positive_regulation RNF19A ARSA 20339548 2444456 Positive_regulation RNF19A ARSA 20339548 2444484 Positive_regulation RNF19A ARSA 24586486 2925124 Positive_regulation RNF19A CAPN8 25079291 620295 Positive_regulation RNF19A CD14 20011115 3045925 Positive_regulation RNF19A CTGF 23227240 2725726 Positive_regulation RNF19A EDN2 24695532 2948215 Positive_regulation RNF19A EPHB2 17105652 106833 Positive_regulation RNF19A EPHB2 20939017 1237853 Positive_regulation RNF19A EPHB2 22675451 2648304 Positive_regulation RNF19A EPHB2 22933112 724433 Positive_regulation RNF19A EPHB2 23079107 409271 Positive_regulation RNF19A EPHB2 23389627 1811943 Positive_regulation RNF19A EPHB2 24647471 2936145 Positive_regulation RNF19A FAS 9362518 1464833 Positive_regulation RNF19A FBXO32 23046544 3161170 Positive_regulation RNF19A FBXO32 23046544 3161245 Positive_regulation RNF19A MAP2K6 17391532 3107961 Positive_regulation RNF19A MAP2K6 20026657 1369842 Positive_regulation RNF19A MAP2K6 20300552 1672034 Positive_regulation RNF19A MAP2K6 23349819 2743364 Positive_regulation RNF19A MAP2K6 23926438 2121554 Positive_regulation RNF19A MAP2K6 9314533 1463473 Positive_regulation RNF19A MMP28 23878609 821682 Positive_regulation RNF19A MMP7 23878609 821698 Positive_regulation RNF19A PGC 23431285 3076361 Positive_regulation RNF19A RAB31 22852067 3184117 Positive_regulation RNF19A S100B 21779383 2537033 Positive_regulation RNF19A S100B 23259641 1665787 Positive_regulation RNF19A SCCPDH 22343628 1201271 Positive_regulation RNF19A TLR7 19043549 3042321 Positive_regulation RNF19A TLR7 21064192 775611 Positive_regulation RNF19A TLR7 22253793 2587917 Positive_regulation RNF19A TLR7 22253793 2587933 Positive_regulation RNF19A TLR7 22253793 2587964 Positive_regulation RNF19A TLR7 22253793 2587994 Positive_regulation RNF19A TLR7 22984582 2689146 Positive_regulation RNF19A TLR7 25057505 1622602 Positive_regulation RNF19A TNF 14613529 3095419 Positive_regulation RNF19A TNF 16207331 104235 Positive_regulation RNF19A TNF 17342245 810724 Positive_regulation RNF19A TNF 18404427 3087214 Positive_regulation RNF19A TNF 19442267 1696264 Positive_regulation RNF19A TNF 19826422 432921 Positive_regulation RNF19A TNF 20308428 1373852 Positive_regulation RNF19A TNF 20644550 10416 Positive_regulation RNF19A TNF 22140576 2576893 Positive_regulation RNF19A TNF 22802702 1714297 Positive_regulation RNF19A TNF 23671702 2792505 Positive_regulation RNF19A TNF 24502696 1233036 Positive_regulation RNF19A TNF 24502696 1233147 Positive_regulation RNF19A TNF 24773466 34200 Positive_regulation RNF19A TNF 24821138 2969092 Positive_regulation RNF19A TNF 25114952 3156808 Positive_regulation RNF19A TNF 25435878 1074927 Positive_regulation RNF2 TNF 22891766 245157 Positive_regulation RNF20 TNF 22891766 245158 Positive_regulation RNF207 TNF 22891766 245223 Positive_regulation RNF208 TNF 22891766 245206 Positive_regulation RNF212 TNF 22891766 245214 Positive_regulation RNF213 TNF 22891766 245168 Positive_regulation RNF214 TNF 22891766 245204 Positive_regulation RNF215 TNF 22891766 245224 Positive_regulation RNF216 TNF 22891766 245198 Positive_regulation RNF217 TNF 22891766 245197 Positive_regulation RNF219 TNF 22891766 245185 Positive_regulation RNF220 TNF 22891766 245207 Positive_regulation RNF222 TNF 22891766 245225 Positive_regulation RNF223 TNF 22891766 245226 Positive_regulation RNF224 TNF 22891766 245227 Positive_regulation RNF24 TNF 22891766 245167 Positive_regulation RNF25 TNF 22891766 245170 Positive_regulation RNF26 TNF 22891766 245169 Positive_regulation RNF31 TNF 22891766 245171 Positive_regulation RNF32 TNF 22891766 245174 Positive_regulation RNF34 TNF 22891766 245175 Positive_regulation RNF38 TNF 22891766 245178 Positive_regulation RNF39 TNF 22891766 245179 Positive_regulation RNF4 TNF 22891766 245159 Positive_regulation RNF40 TNF 22891766 245172 Positive_regulation RNF41 TNF 22891766 245182 Positive_regulation RNF43 TNF 22891766 245183 Positive_regulation RNF44 TNF 22891766 245184 Positive_regulation RNF5 EPHB2 17591920 1341663 Positive_regulation RNF5 EPHB2 17591920 1341667 Positive_regulation RNF5 EPHB2 17591920 1341673 Positive_regulation RNF5 TNF 22891766 245160 Positive_regulation RNF6 TNF 22891766 245161 Positive_regulation RNF7 TNF 22891766 245162 Positive_regulation RNF8 TNF 22891766 245163 Positive_regulation RNU12-2P IFI27 25486097 3032732 Positive_regulation ROCK1 CTGF 20858895 1188518 Positive_regulation ROCK1 EPHB2 19737544 154055 Positive_regulation ROCK1 EPHB2 24885257 290319 Positive_regulation ROCK1 EPHB2 25121106 196637 Positive_regulation ROCK1 FAS 18955552 1359442 Positive_regulation ROCK1 FAS 22918940 1806610 Positive_regulation ROCK1 MAP2K6 19077254 385154 Positive_regulation ROCK1 MAP2K6 22213560 3171832 Positive_regulation ROCK1 TNF 22688336 723174 Positive_regulation ROCK1 TNF 22688336 723181 Positive_regulation ROCK2 CTGF 20858895 1188519 Positive_regulation ROCK2 EPHB2 19737544 154056 Positive_regulation ROCK2 EPHB2 24885257 290322 Positive_regulation ROCK2 EPHB2 25121106 196639 Positive_regulation ROCK2 FAS 18955552 1359443 Positive_regulation ROCK2 FAS 22918940 1806611 Positive_regulation ROCK2 MAP2K6 22213560 3171839 Positive_regulation ROCK2 TNF 22688336 723176 Positive_regulation ROCK2 TNF 22688336 723182 Positive_regulation ROR1 WNT7A 24204697 2873498 Positive_regulation RORC AHR 22888330 903078 Positive_regulation RORC ARNTL 18454201 2305286 Positive_regulation RORC ARNTL 18454201 2305287 Positive_regulation RORC ARNTL 18454201 2305304 Positive_regulation RORC ARNTL 18454201 2305311 Positive_regulation RORC ARNTL 18454201 2305318 Positive_regulation RORC CDC73 22013287 1749581 Positive_regulation RORC CLOCK 18454201 2305285 Positive_regulation RORC CLOCK 18454201 2305303 Positive_regulation RORC CLOCK 18454201 2305317 Positive_regulation RORC CTR9 22013287 1749582 Positive_regulation RORC HNRNPF 22643849 1918760 Positive_regulation RORC HNRNPF 22643849 1918761 Positive_regulation RORC HNRNPH1 22643849 1918762 Positive_regulation RORC HNRNPH1 22643849 1918763 Positive_regulation RORC IL12A 23110343 339526 Positive_regulation RORC IL12B 23110343 339527 Positive_regulation RORC IL12B 25566265 921695 Positive_regulation RORC IL17A 23110343 339528 Positive_regulation RORC IL17A 24395888 1574426 Positive_regulation RORC IL1A 23874332 908183 Positive_regulation RORC IL1A 24013901 2842170 Positive_regulation RORC IL23A 25566265 921694 Positive_regulation RORC IL6 24013901 2842171 Positive_regulation RORC IL6 24453425 1756972 Positive_regulation RORC IL6 24885744 396644 Positive_regulation RORC KLRB1 24223933 2877408 Positive_regulation RORC LEO1 22013287 1749585 Positive_regulation RORC MYLIP 23359619 2744991 Positive_regulation RORC NRIP1 21628546 1211412 Positive_regulation RORC PAF1 22013287 1749583 Positive_regulation RORC PTBP1 22643849 1918764 Positive_regulation RORC PTBP1 22643849 1918765 Positive_regulation RORC PTBP2 22643849 1918758 Positive_regulation RORC PTBP2 22643849 1918759 Positive_regulation RORC RUNX1 21151104 1954761 Positive_regulation RORC RUNX1 21151104 1954777 Positive_regulation RORC RUNX1 21151104 1954786 Positive_regulation RORC RUNX1 25123277 1043406 Positive_regulation RORC SOCS1 23936569 2372021 Positive_regulation RORC STAT3 22132325 1686794 Positive_regulation RORC WDR61 22013287 1749584 Positive_regulation RPAP1 PGC 17389765 3071449 Positive_regulation RPAP1 TNF 21298084 2320998 Positive_regulation RPE MAP2K6 17277739 1906420 Positive_regulation RPH3AL MMP7 11980922 1282553 Positive_regulation RPL17 EPHB2 23742646 3121841 Positive_regulation RPL17 TLR7 21706028 1961427 Positive_regulation RPL17 TLR7 25279955 3012279 Positive_regulation RPL23A FHL1 21045055 2057813 Positive_regulation RPLP1 TNF 24663085 1125568 Positive_regulation RPS10 EPHB2 20162012 1089289 Positive_regulation RPS10 FHL1 17937820 233631 Positive_regulation RPS10 FHL1 20122284 402248 Positive_regulation RPS11 EPHB2 20162012 1089290 Positive_regulation RPS11 FHL1 17937820 233632 Positive_regulation RPS11 FHL1 20122284 402250 Positive_regulation RPS12 EPHB2 20162012 1089291 Positive_regulation RPS12 FHL1 17937820 233633 Positive_regulation RPS12 FHL1 20122284 402252 Positive_regulation RPS13 EPHB2 20162012 1089292 Positive_regulation RPS13 FHL1 17937820 233634 Positive_regulation RPS13 FHL1 20122284 402254 Positive_regulation RPS14 EPHB2 20162012 1089293 Positive_regulation RPS14 FHL1 17937820 233635 Positive_regulation RPS14 FHL1 20122284 402256 Positive_regulation RPS15 EPHB2 20162012 1089294 Positive_regulation RPS15 EPHB2 22087839 681986 Positive_regulation RPS15 EPHB2 22087839 682010 Positive_regulation RPS15 FHL1 17937820 233636 Positive_regulation RPS15 FHL1 20122284 402258 Positive_regulation RPS16 EPHB2 20162012 1089295 Positive_regulation RPS16 FHL1 17937820 233637 Positive_regulation RPS16 FHL1 20122284 402260 Positive_regulation RPS17 EPHB2 20162012 1089296 Positive_regulation RPS17 FHL1 17937820 233638 Positive_regulation RPS17 FHL1 20122284 402262 Positive_regulation RPS18 EPHB2 20162012 1089297 Positive_regulation RPS18 FHL1 17937820 233639 Positive_regulation RPS18 FHL1 20122284 402264 Positive_regulation RPS19 EPHB2 20162012 1089298 Positive_regulation RPS19 FHL1 17937820 233640 Positive_regulation RPS19 FHL1 20122284 402266 Positive_regulation RPS2 EPHB2 20162012 1089299 Positive_regulation RPS2 FHL1 17937820 233641 Positive_regulation RPS2 FHL1 20122284 402268 Positive_regulation RPS20 EPHB2 20162012 1089300 Positive_regulation RPS20 FAS 22929310 1506541 Positive_regulation RPS20 FHL1 17937820 233642 Positive_regulation RPS20 FHL1 20122284 402270 Positive_regulation RPS21 EPHB2 20162012 1089301 Positive_regulation RPS21 EPHB2 22715416 2653053 Positive_regulation RPS21 FHL1 17937820 233643 Positive_regulation RPS21 FHL1 20122284 402272 Positive_regulation RPS23 EPHB2 20162012 1089302 Positive_regulation RPS23 FHL1 17937820 233644 Positive_regulation RPS23 FHL1 20122284 402274 Positive_regulation RPS24 EPHB2 20162012 1089303 Positive_regulation RPS24 FHL1 17937820 233645 Positive_regulation RPS24 FHL1 20122284 402276 Positive_regulation RPS25 EPHB2 20162012 1089304 Positive_regulation RPS25 FHL1 17937820 233646 Positive_regulation RPS25 FHL1 20122284 402278 Positive_regulation RPS26 EPHB2 20162012 1089305 Positive_regulation RPS26 FHL1 17937820 233647 Positive_regulation RPS26 FHL1 20122284 402280 Positive_regulation RPS27 EPHB2 20162012 1089306 Positive_regulation RPS27 FHL1 17937820 233648 Positive_regulation RPS27 FHL1 20122284 402282 Positive_regulation RPS28 EPHB2 20162012 1089307 Positive_regulation RPS28 EPHB2 25254549 2364768 Positive_regulation RPS28 FHL1 17937820 233649 Positive_regulation RPS28 FHL1 20122284 402284 Positive_regulation RPS29 EPHB2 20162012 1089308 Positive_regulation RPS29 FHL1 17937820 233650 Positive_regulation RPS29 FHL1 20122284 402286 Positive_regulation RPS3 EPHB2 20162012 1089309 Positive_regulation RPS3 FHL1 17937820 233651 Positive_regulation RPS3 FHL1 20122284 402288 Positive_regulation RPS3 TNF 21399639 1955123 Positive_regulation RPS3 TNF 21399639 1955124 Positive_regulation RPS3 TNF 21399639 1955139 Positive_regulation RPS3 TNF 21399639 1955140 Positive_regulation RPS3 TNF 21399639 1955155 Positive_regulation RPS3 TNF 21399639 1955156 Positive_regulation RPS3 TNF 21399639 1955164 Positive_regulation RPS3 TNF 21399639 1955165 Positive_regulation RPS5 EPHB2 20162012 1089310 Positive_regulation RPS5 FHL1 17937820 233652 Positive_regulation RPS5 FHL1 20122284 402290 Positive_regulation RPS6 EPHB2 20162012 1089311 Positive_regulation RPS6 FHL1 17937820 233653 Positive_regulation RPS6 FHL1 20122284 402292 Positive_regulation RPS6KA1 EPHB2 19707375 175676 Positive_regulation RPS6KA1 EPHB2 21219631 258374 Positive_regulation RPS6KA1 EPHB2 21219631 258375 Positive_regulation RPS6KA1 EPHB2 21219631 258389 Positive_regulation RPS6KA1 EPHB2 21887372 2549672 Positive_regulation RPS6KA1 MAP2K6 23826126 2810466 Positive_regulation RPS6KA3 EPHB2 21902831 3160598 Positive_regulation RPS6KA3 FOXO1 22675309 957675 Positive_regulation RPS6KA4 EPHB2 23675462 2793035 Positive_regulation RPS6KA5 EPHB2 12769834 369171 Positive_regulation RPS6KA5 EPHB2 19707375 175677 Positive_regulation RPS6KA5 EPHB2 19956756 2432684 Positive_regulation RPS6KA5 EPHB2 21109534 2059096 Positive_regulation RPS6KA5 EPHB2 21139994 1242986 Positive_regulation RPS6KA5 EPHB2 21779236 933164 Positive_regulation RPS6KA5 EPHB2 22140508 2574851 Positive_regulation RPS6KA5 EPHB2 22140508 2574868 Positive_regulation RPS6KA5 EPHB2 22312244 1094820 Positive_regulation RPS6KA5 EPHB2 23536830 2773129 Positive_regulation RPS6KA5 EPHB2 24349124 2896783 Positive_regulation RPS6KA5 EPHB2 24647471 2936144 Positive_regulation RPS6KA5 MAP2K6 23536830 2773090 Positive_regulation RPS6KA5 MAP2K6 23536830 2773094 Positive_regulation RPS6KA5 PGC 21493629 1033397 Positive_regulation RPS6KA5 PGC 21493629 1033398 Positive_regulation RPS6KA5 TNF 24603712 2931963 Positive_regulation RPS6KA5 TNF 24603712 2931979 Positive_regulation RPS6KA5 TNF 24603712 2931989 Positive_regulation RPS6KA5 TNF 24705157 985046 Positive_regulation RPS6KB1 EPHB2 18320031 2384858 Positive_regulation RPS6KB1 FBXO32 20126553 2439303 Positive_regulation RPS6KB1 FOXO1 23383714 987987 Positive_regulation RPS6KB1 S100B 25221943 3007229 Positive_regulation RPS6KB1 TNF 22848663 2669987 Positive_regulation RPS7 EPHB2 20162012 1089312 Positive_regulation RPS7 FHL1 17937820 233654 Positive_regulation RPS7 FHL1 20122284 402294 Positive_regulation RPS8 EPHB2 20162012 1089313 Positive_regulation RPS8 FHL1 17937820 233655 Positive_regulation RPS8 FHL1 20122284 402296 Positive_regulation RPS9 EPHB2 20162012 1089314 Positive_regulation RPS9 FHL1 17937820 233656 Positive_regulation RPS9 FHL1 20122284 402298 Positive_regulation RPS9 RNASE1 24009741 2841588 Positive_regulation RPTOR CCND1 22359572 2597712 Positive_regulation RPTOR EPHB2 21200439 2489540 Positive_regulation RPTOR EPHB2 21283628 2496977 Positive_regulation RPTOR EPHB2 21738705 2533413 Positive_regulation RPTOR EPHB2 22028687 860488 Positive_regulation RPTOR EPHB2 22028687 860510 Positive_regulation RPTOR EPHB2 22028687 860561 Positive_regulation RPTOR EPHB2 22159814 1140669 Positive_regulation RPTOR EPHB2 22880048 2673711 Positive_regulation RPTOR EPHB2 23077579 2704795 Positive_regulation RPTOR EPHB2 23077579 2704803 Positive_regulation RPTOR EPHB2 23077579 2704810 Positive_regulation RPTOR EPHB2 23431403 2755367 Positive_regulation RPTOR EPHB2 23431403 2755430 Positive_regulation RPTOR EPHB2 23431403 2755439 Positive_regulation RPTOR EPHB2 23624914 2152078 Positive_regulation RPTOR EPHB2 23624914 2152091 Positive_regulation RPTOR EPHB2 23862076 2003127 Positive_regulation RPTOR EPHB2 24303063 2887907 Positive_regulation RPTOR EPHB2 24612393 1692527 Positive_regulation RPTOR EPHB2 24710474 618071 Positive_regulation RPTOR EPHB2 24710474 618108 Positive_regulation RPTOR FOXO1 24228024 694180 Positive_regulation RPTOR MAP2K6 21738705 2533419 Positive_regulation RPTOR RAB31 22523661 1670305 Positive_regulation RREB1 PGC 22453831 1933599 Positive_regulation RSPO1 HBEGF 22157721 1717829 Positive_regulation RSPO1 HBEGF 22157721 1717830 Positive_regulation RTL1 TNF 25409514 3028774 Positive_regulation RTN4 RNASE1 22174690 3055128 Positive_regulation RTN4 RNASE7 22174690 3055136 Positive_regulation RUNX1 EPHB2 22253733 2587788 Positive_regulation RUNX1 EPHB2 24681962 219077 Positive_regulation RUNX1 FOXO1 21765927 2536269 Positive_regulation RUNX1T1 FOXO1 21143873 331770 Positive_regulation RUNX2 CCND1 16984628 370110 Positive_regulation RUNX2 CCND1 20726009 161283 Positive_regulation RUNX2 EPHB2 18047638 280704 Positive_regulation RUNX2 EPHB2 20939017 1237850 Positive_regulation RUNX2 EPHB2 22433113 1675694 Positive_regulation RUNX2 EPHB2 24086598 2854995 Positive_regulation RUNX2 EPHB2 24605332 187463 Positive_regulation RUNX2 EPHB2 24795772 825687 Positive_regulation RUNX2 FOXO1 25187705 1138331 Positive_regulation RUNX2 TNF 20808842 2472748 Positive_regulation RUNX2 TNF 22396737 2608357 Positive_regulation RUNX2 TNF 22396737 2608364 Positive_regulation RUNX2 TNF 22396737 2608371 Positive_regulation RUNX2 TNF 23818912 637884 Positive_regulation RUNX2 TNF 23969857 564942 Positive_regulation RUNX2 ZFP57 21173110 1383607 Positive_regulation RXRA EFNB1 18618001 2305572 Positive_regulation RXRB ARSA 15824083 1535487 Positive_regulation RYK AXIN2 21814488 2276956 Positive_regulation RYR1 TNF 24303157 2251408 Positive_regulation RYR1 TNF 24776599 514456 Positive_regulation RYR1 TNF 24776599 514499 Positive_regulation RYR2 TNF 24303157 2251409 Positive_regulation RYR2 TNF 24776599 514457 Positive_regulation RYR2 TNF 24776599 514500 Positive_regulation RYR3 TNF 24303157 2251410 Positive_regulation RYR3 TNF 24776599 514458 Positive_regulation RYR3 TNF 24776599 514501 Positive_regulation S100A1 TNF 16613612 105703 Positive_regulation S100A12 CCL17 25010197 2987897 Positive_regulation S100A12 EPHB2 21933441 1898415 Positive_regulation S100A12 EPHB2 21933441 1898417 Positive_regulation S100A12 EPHB2 22742729 1899188 Positive_regulation S100A12 F2R 20875131 1897684 Positive_regulation S100A12 F2R 24215724 538041 Positive_regulation S100A12 TNF 16864903 1740276 Positive_regulation S100A12 TNF 21909201 88165 Positive_regulation S100A12 TNF 22072275 1615982 Positive_regulation S100A12 TNF 25159733 3145294 Positive_regulation S100A2 TP63 18388131 2034113 Positive_regulation S100A2 TP63 18388131 2034129 Positive_regulation S100A4 EPHB2 23383075 2747893 Positive_regulation S100A4 FOXQ1 25356753 2206493 Positive_regulation S100A6 HBEGF 23029355 2696788 Positive_regulation S100A6 TNF 20672023 512972 Positive_regulation S100A6 TNF 22829076 217710 Positive_regulation S100A6 TNF 22829076 217711 Positive_regulation S100A6 TNF 22829076 217715 Positive_regulation S100A7 CDKN2A 25621169 1727227 Positive_regulation S100A7 CDKN2A 25621169 1727242 Positive_regulation S100A7 EGF 18320059 2384882 Positive_regulation S100A7 EGF 23300877 2736951 Positive_regulation S100A7 GLI1 25072505 2992941 Positive_regulation S100A7 HSPG2 23300877 2736926 Positive_regulation S100A7 IFNG 17986321 250466 Positive_regulation S100A7 IFNG 17986321 250478 Positive_regulation S100A7 IL17A 21283546 2495610 Positive_regulation S100A7 IL17A 21283546 2495612 Positive_regulation S100A7 IL17A 21283546 2495614 Positive_regulation S100A7 IL17A 23193414 1156325 Positive_regulation S100A7 IL17A 23197904 88209 Positive_regulation S100A7 IL17A 23555696 2774909 Positive_regulation S100A7 IL17A 24901012 1621728 Positive_regulation S100A7 IL17A 25140116 1761014 Positive_regulation S100A7 IL1A 23193414 1156326 Positive_regulation S100A7 IL1A 25010647 2987981 Positive_regulation S100A7 IL22 21283546 2495609 Positive_regulation S100A7 IL22 21283546 2495611 Positive_regulation S100A7 IL22 21283546 2495613 Positive_regulation S100A7 IL22 23197904 88208 Positive_regulation S100A7 IL22 23386905 1239740 Positive_regulation S100A7 IL22 23386905 1239743 Positive_regulation S100A7 IL22 24312440 2889475 Positive_regulation S100A7 IL22 24901012 1621727 Positive_regulation S100A7 IL22 25010647 2987980 Positive_regulation S100A7 IL22 25140116 1761013 Positive_regulation S100A7 IL22 25226283 3007713 Positive_regulation S100A7 OSM 25010647 2987982 Positive_regulation S100A7 SOCS1 15217497 458469 Positive_regulation S100A7 TNF 22230654 3112892 Positive_regulation S100A7 TNF 24901012 1621726 Positive_regulation S100A7 TP53 25621169 1727226 Positive_regulation S100A7 VEGFA 23300877 2736949 Positive_regulation S100A8 EPHB2 22817771 471872 Positive_regulation S100A8 EPHB2 22817771 472015 Positive_regulation S100A8 EPHB2 23342256 491853 Positive_regulation S100A8 EPHB2 24133496 909250 Positive_regulation S100A8 MAP2K6 23342256 491859 Positive_regulation S100A8 MAP2K6 24133496 909258 Positive_regulation S100A8 TNF 16613612 105707 Positive_regulation S100A8 TNF 19284577 112939 Positive_regulation S100A8 TNF 22313861 3160894 Positive_regulation S100A8 TNF 22313861 3160941 Positive_regulation S100A8 TNF 22313861 3160963 Positive_regulation S100A8 TNF 23721320 1666738 Positive_regulation S100A8 TNF 23762562 1690698 Positive_regulation S100A8 TNF 24156302 3122339 Positive_regulation S100A9 TNF 16613612 105724 Positive_regulation S100A9 TNF 21738489 2325068 Positive_regulation S100A9 TNF 23721320 1666740 Positive_regulation S100A9 TNF 23762562 1690699 Positive_regulation S100B ACSM3 20671945 512952 Positive_regulation S100B AGTR1 21970823 1659861 Positive_regulation S100B APP 21779383 2537038 Positive_regulation S100B APP 23866266 1666875 Positive_regulation S100B APP 23866266 1666884 Positive_regulation S100B APP 23866266 1666901 Positive_regulation S100B ARFIP1 20827422 513114 Positive_regulation S100B CA2 20827422 513096 Positive_regulation S100B CA2 20827422 513102 Positive_regulation S100B CA2 20827422 513116 Positive_regulation S100B CA2 24723847 931609 Positive_regulation S100B CA2 24808824 931812 Positive_regulation S100B CA9 6257728 1430675 Positive_regulation S100B CASP3 20672051 512988 Positive_regulation S100B CCL2 PMC4070603 3206020 Positive_regulation S100B CDKN1A 25536222 3035762 Positive_regulation S100B EN1 17362503 299795 Positive_regulation S100B FPR2 23164356 1895691 Positive_regulation S100B GUCY2D 24723847 931610 Positive_regulation S100B GUCY2D 25071437 932113 Positive_regulation S100B HOXC11 21654685 436847 Positive_regulation S100B IL1A 19668572 649434 Positive_regulation S100B IL1A 19668572 649440 Positive_regulation S100B IL1A 19668572 649441 Positive_regulation S100B IL1A 22022205 1628162 Positive_regulation S100B IL1A 22200088 1660419 Positive_regulation S100B IL1A 23866266 1666883 Positive_regulation S100B IL1A 23866266 1666900 Positive_regulation S100B IL6 PMC4070603 3206021 Positive_regulation S100B MAPK3 23164356 1895679 Positive_regulation S100B MAPK3 23164356 1895680 Positive_regulation S100B MLST8 25221943 3007211 Positive_regulation S100B MOK 19292913 1695976 Positive_regulation S100B MOK 20672051 512982 Positive_regulation S100B MOK 20827311 512998 Positive_regulation S100B MOK 20827421 513032 Positive_regulation S100B MOK 21614209 1090917 Positive_regulation S100B MOK 22779027 1052996 Positive_regulation S100B MOK 23166536 1028675 Positive_regulation S100B MTOR 25221943 3007213 Positive_regulation S100B MYLIP 24725992 3169949 Positive_regulation S100B NCOA1 21654685 436848 Positive_regulation S100B NCOA1 21654685 436853 Positive_regulation S100B NOS2 20672023 512970 Positive_regulation S100B OXA1L 24725992 3169950 Positive_regulation S100B PRMT2 23866266 1666882 Positive_regulation S100B RNF19A 21779383 2537032 Positive_regulation S100B RPS6KB1 25221943 3007204 Positive_regulation S100B RPS6KB1 25221943 3007205 Positive_regulation S100B RPS6KB1 25221943 3007232 Positive_regulation S100B RPTOR 25221943 3007212 Positive_regulation S100B SOD1 23866266 1666880 Positive_regulation S100B SOX10 25536222 3035721 Positive_regulation S100B SOX10 25536222 3035723 Positive_regulation S100B SOX9 25536222 3035725 Positive_regulation S100B SOX9 25536222 3035765 Positive_regulation S100B TIAM1 23866266 1666881 Positive_regulation S100B TLR4 21970823 1659864 Positive_regulation S100B TP53 22949826 1097884 Positive_regulation S100B TUBB3 24725992 3169948 Positive_regulation S100G IL1B 25049477 136115 Positive_regulation S100G IL1B 25049477 136120 Positive_regulation S11 TNF 3491174 1583111 Positive_regulation S11 TNF 3772296 1583655 Positive_regulation S11 TNS1 479759 1584188 Positive_regulation S12 TNF 3491174 1583113 Positive_regulation S12 TNF 3772296 1583656 Positive_regulation S12 TNS1 479759 1584189 Positive_regulation S1PR1 EPHB2 21686182 1091048 Positive_regulation S1PR1 EPHB2 21977292 1028031 Positive_regulation S1PR1 F2R 22482044 661515 Positive_regulation S1PR1 FOXO1 25330112 3017198 Positive_regulation S1PR1 S1PR3 23911934 699096 Positive_regulation S1PR1 S1PR3 25147438 1761269 Positive_regulation S1PR1 SPHK1 24025642 1709537 Positive_regulation S1PR1 SPHK1 24349009 2896548 Positive_regulation S1PR3 EPHB2 21686182 1091050 Positive_regulation S1PR3 EPX 21686182 1091051 Positive_regulation S1PR3 KLF2 17908937 1547211 Positive_regulation S1PR3 LPA 21936950 1697762 Positive_regulation S1PR3 MBTPS1 16636149 1329283 Positive_regulation S1PR3 MBTPS1 21687504 950272 Positive_regulation S1PR3 MBTPS1 22096531 2571679 Positive_regulation S1PR3 MBTPS1 22547907 1749690 Positive_regulation S1PR3 MBTPS1 23781203 961488 Positive_regulation S1PR3 MBTPS1 24222847 627868 Positive_regulation S1PR3 MBTPS1 24632890 2934621 Positive_regulation S1PR3 MBTPS1 24832383 152800 Positive_regulation S1PR3 MBTPS1 25198418 3005990 Positive_regulation S1PR3 MBTPS1 25598849 2208383 Positive_regulation S1PR3 NOS3 24830642 2970298 Positive_regulation S1PR3 PIK3CA 21304987 2502019 Positive_regulation S1PR3 PIK3R1 21304987 2502020 Positive_regulation S1PR3 RAC1 21304987 2502021 Positive_regulation S1PR3 RAC2 21304987 2502022 Positive_regulation S1PR3 RAC3 21304987 2502023 Positive_regulation S1PR3 SMAD1 20089836 1773240 Positive_regulation S1PR3 SMAD2 20089836 1773241 Positive_regulation S1PR3 SMAD3 20089836 1773242 Positive_regulation S1PR3 SMAD4 20089836 1773243 Positive_regulation S1PR3 SMAD5 20089836 1773244 Positive_regulation S1PR3 SMAD6 20089836 1773245 Positive_regulation S1PR3 SMAD7 20089836 1773246 Positive_regulation S1PR3 SMAD9 20089836 1773247 Positive_regulation S1PR3 SPHK1 16636149 1329299 Positive_regulation S7 TNF 3491174 1583115 Positive_regulation S7 TNF 3772296 1583657 Positive_regulation S7 TNS1 479759 1584190 Positive_regulation SAA1 CD14 17997851 1625036 Positive_regulation SAA1 EPHB2 22610094 1203376 Positive_regulation SAA1 GPR115 12857601 1738708 Positive_regulation SAA1 GPR132 12857601 1738697 Positive_regulation SAA1 GPR87 12857601 1738777 Positive_regulation SAA1 IL1B 12857601 1738638 Positive_regulation SAA1 MUC16 25136510 84961 Positive_regulation SAA1 TNF 16737350 2368807 Positive_regulation SAA1 TNF 18700003 19843 Positive_regulation SAA1 TNF 19043563 1746396 Positive_regulation SAA1 TNF 19043563 1746404 Positive_regulation SAA1 TNF 19351711 708226 Positive_regulation SAA1 TNF 21394207 2506563 Positive_regulation SAA1 TNF 21394207 2506569 Positive_regulation SAA1 TNF 22072820 1713174 Positive_regulation SAA1 TNF 24651840 2937268 Positive_regulation SAA1 TNF 24651840 2937269 Positive_regulation SAA1 TNF 24651840 2937271 Positive_regulation SAA1 TNF 24651840 2937274 Positive_regulation SAA1 TNF 24651840 2937276 Positive_regulation SAA1 TNF 24651840 2937279 Positive_regulation SAA1 TNF 24651840 2937281 Positive_regulation SAA1 TNF 24920450 3224731 Positive_regulation SAA2 GPR115 12857601 1738801 Positive_regulation SAA2 GPR132 12857601 1738790 Positive_regulation SAA2 GPR87 12857601 1738870 Positive_regulation SAA2 TNF 21394207 2506564 Positive_regulation SAA2 TNF 21394207 2506570 Positive_regulation SAA2 TNF 23840908 2818800 Positive_regulation SAA3P TLR7 19513118 2418672 Positive_regulation SAA3P TNF 19513118 2418662 Positive_regulation SAA3P TNF 19513118 2418664 Positive_regulation SAA3P TNF 19513118 2418671 Positive_regulation SAA3P TNF 24694941 1703521 Positive_regulation SAA3P TNF 24694941 1703540 Positive_regulation SAA4 GPR115 12857601 1738894 Positive_regulation SAA4 GPR132 12857601 1738883 Positive_regulation SAA4 GPR87 12857601 1738963 Positive_regulation SAA4 TNF 21394207 2506565 Positive_regulation SAA4 TNF 21394207 2506571 Positive_regulation SAG TNF 24205055 2875154 Positive_regulation SAP130 NES 24552625 2013135 Positive_regulation SAP130 TNF 7931061 1593053 Positive_regulation SAP30 NES 24552625 2013099 Positive_regulation SAP30 TNF 7931061 1593036 Positive_regulation SARM1 MAVS 24651600 3066468 Positive_regulation SATB2 MSX1 23280066 409342 Positive_regulation SCARA3 APOB 21850203 1057524 Positive_regulation SCARB1 ARSA 20137092 1722988 Positive_regulation SCARB1 PDZK1 16197558 2013435 Positive_regulation SCARB1 PDZK1 19169357 2404647 Positive_regulation SCARB1 PDZK1 19654867 2422723 Positive_regulation SCARB1 PDZK1 19956623 2432305 Positive_regulation SCARB1 PDZK1 20515451 2112665 Positive_regulation SCARB1 PDZK1 20949066 3048886 Positive_regulation SCARB1 PDZK1 20949066 3048887 Positive_regulation SCARB1 PDZK1 20949066 3048890 Positive_regulation SCARB1 PDZK1 21490774 627739 Positive_regulation SCARB1 PDZK1 23936087 2829378 Positive_regulation SCARB1 PDZK1 23936087 2829379 Positive_regulation SCARB1 PDZK1 23936087 2829387 Positive_regulation SCARB1 PDZK1 23936087 2829388 Positive_regulation SCARB1 PDZK1 23936087 2829389 Positive_regulation SCARB1 TNFSF10 24466325 2914326 Positive_regulation SCD FAS 22413010 2610084 Positive_regulation SCD FAS 23298201 1725204 Positive_regulation SCD FAS 25590576 2301615 Positive_regulation SCG2 EDN2 21955788 405619 Positive_regulation SCG3 EDN2 21955788 405625 Positive_regulation SCG5 EDN2 21955788 405622 Positive_regulation SCGB1A1 SUSD2 25351403 3146316 Positive_regulation SCGB1A1 SUSD2 25351403 3146319 Positive_regulation SCGB1A1 TNF PMC3643277 3225813 Positive_regulation SCGB1D4 FOXO1 24115839 742827 Positive_regulation SCGB3A1 IL13 18194566 371336 Positive_regulation SCGB3A1 IL3 18194566 371338 Positive_regulation SCGB3A1 IL4 18194566 371337 Positive_regulation SCGB3A1 NFYA 18194566 371316 Positive_regulation SCGB3A1 NFYA 18194566 371317 Positive_regulation SCGB3A1 NFYB 18194566 371318 Positive_regulation SCGB3A1 NFYB 18194566 371319 Positive_regulation SCGB3A1 NFYC 18194566 371320 Positive_regulation SCGB3A1 NFYC 18194566 371321 Positive_regulation SCIN BPNT1 21346779 988668 Positive_regulation SCIN CA2 1331119 1297599 Positive_regulation SCIN CA2 1331119 1297603 Positive_regulation SCIN CA2 20440404 1056058 Positive_regulation SCIN CA2 23805129 878908 Positive_regulation SCIN CA2 24901433 2976851 Positive_regulation SCML2 IFI27 24358021 2285072 Positive_regulation SCN5A FOXO1 23393573 2751191 Positive_regulation SCN5A FOXO1 23393573 2751203 Positive_regulation SCT TLR7 23550085 1492870 Positive_regulation SDC1 CHI3L1 20540736 1656241 Positive_regulation SDC1 CHI3L1 23755018 961345 Positive_regulation SDC1 EPHB2 23304519 1496995 Positive_regulation SDC1 MMP28 10684261 1256078 Positive_regulation SDC1 MMP7 10684261 1256093 Positive_regulation SDC2 EPHB2 17548511 1341004 Positive_regulation SDC2 HBEGF 19829704 2428762 Positive_regulation SDC2 MMP28 10684261 1256100 Positive_regulation SDC2 MMP7 10684261 1256115 Positive_regulation SDC2 SARM1 25221470 939087 Positive_regulation SDC3 MMP28 10684261 1256122 Positive_regulation SDC3 MMP7 10684261 1256137 Positive_regulation SDC4 GPNMB 23874106 2121507 Positive_regulation SDC4 MMP28 10684261 1256144 Positive_regulation SDC4 MMP7 10684261 1256159 Positive_regulation SDC4 TNF 19093006 1908627 Positive_regulation SDCBP SPRR1B 25593999 2173510 Positive_regulation SDCCAG8 NES 15251038 277757 Positive_regulation SDHB EGLN3 22888353 1068792 Positive_regulation SEA EPHB2 22110388 1058549 Positive_regulation SEA TLR7 20204176 1213989 Positive_regulation SEA TNF 16614521 1634730 Positive_regulation SEA TNF 21931534 2277139 Positive_regulation SEA TNF 2258710 1568225 Positive_regulation SEA TNF 23270458 357305 Positive_regulation SEA TNF 23589093 94844 Positive_regulation SEC14L2 PRODH 20403182 393319 Positive_regulation SEC14L2 RNASE1 22037499 1967191 Positive_regulation SEC23A CREB3L2 25147951 3001307 Positive_regulation SEC23B CREB3L2 21711675 519069 Positive_regulation SEC24C CREB3L2 21711675 519070 Positive_regulation SEC61B PGC 21475702 1238396 Positive_regulation SELE CHI3L1 7540655 1590360 Positive_regulation SELE CHI3L1 7540655 1590371 Positive_regulation SELE FUT4 8666674 1452104 Positive_regulation SELE ITGB2 21835035 1626400 Positive_regulation SELE ITGB2 23750158 907364 Positive_regulation SELE MAP2K6 24349153 2896874 Positive_regulation SELE NT5E 20181103 1625933 Positive_regulation SELE PECAM1 24707174 1072137 Positive_regulation SELE PECAM1 9314541 1463951 Positive_regulation SELE PECAM1 9314541 1463956 Positive_regulation SELE SELL 7530761 1589947 Positive_regulation SELE SELL 7682218 1438768 Positive_regulation SELE SELL 7682218 1438770 Positive_regulation SELE TNF 11384108 418903 Positive_regulation SELE TNF 12110129 99057 Positive_regulation SELE TNF 12721516 1212061 Positive_regulation SELE TNF 12810688 1527673 Positive_regulation SELE TNF 1281211 1527734 Positive_regulation SELE TNF 12823845 99836 Positive_regulation SELE TNF 12875662 247414 Positive_regulation SELE TNF 12875662 247418 Positive_regulation SELE TNF 1383376 1528828 Positive_regulation SELE TNF 15694007 391914 Positive_regulation SELE TNF 15694007 391915 Positive_regulation SELE TNF 15809354 1535340 Positive_regulation SELE TNF 16236179 3096096 Positive_regulation SELE TNF 17116732 1543369 Positive_regulation SELE TNF 18170931 3228840 Positive_regulation SELE TNF 18472928 1743241 Positive_regulation SELE TNF 18472945 1743272 Positive_regulation SELE TNF 18591389 706351 Positive_regulation SELE TNF 19223596 708072 Positive_regulation SELE TNF 19228707 513363 Positive_regulation SELE TNF 19296842 112992 Positive_regulation SELE TNF 19707438 175838 Positive_regulation SELE TNF 19707438 175841 Positive_regulation SELE TNF 20181103 1625932 Positive_regulation SELE TNF 20181103 1625962 Positive_regulation SELE TNF 20868490 1651264 Positive_regulation SELE TNF 20965218 1492572 Positive_regulation SELE TNF 21572963 2520269 Positive_regulation SELE TNF 21572963 2520288 Positive_regulation SELE TNF 21625416 742463 Positive_regulation SELE TNF 21673972 2528004 Positive_regulation SELE TNF 21788407 1564368 Positive_regulation SELE TNF 21843342 411974 Positive_regulation SELE TNF 22235351 2586523 Positive_regulation SELE TNF 22384091 2603806 Positive_regulation SELE TNF 22414102 682233 Positive_regulation SELE TNF 22427801 2610165 Positive_regulation SELE TNF 22754320 1095967 Positive_regulation SELE TNF 23056947 1145837 Positive_regulation SELE TNF 23071583 2703021 Positive_regulation SELE TNF 23130241 1043805 Positive_regulation SELE TNF 23130241 1043807 Positive_regulation SELE TNF 23130241 1043811 Positive_regulation SELE TNF 23130241 1043814 Positive_regulation SELE TNF 23190900 1631835 Positive_regulation SELE TNF 23398879 3210478 Positive_regulation SELE TNF 23533479 817802 Positive_regulation SELE TNF 23770053 1498344 Positive_regulation SELE TNF 23788975 657447 Positive_regulation SELE TNF 23884101 220652 Positive_regulation SELE TNF 23912327 2117648 Positive_regulation SELE TNF 23929007 87351 Positive_regulation SELE TNF 23929007 87362 Positive_regulation SELE TNF 23929007 87363 Positive_regulation SELE TNF 23987139 412458 Positive_regulation SELE TNF 24228622 359337 Positive_regulation SELE TNF 24228622 359345 Positive_regulation SELE TNF 24228622 359361 Positive_regulation SELE TNF 24228622 359368 Positive_regulation SELE TNF 24386459 2903974 Positive_regulation SELE TNF 24397824 1232872 Positive_regulation SELE TNF 24614329 3140123 Positive_regulation SELE TNF 24707183 3177139 Positive_regulation SELE TNF 24864133 1758810 Positive_regulation SELE TNF 24882978 88405 Positive_regulation SELE TNF 25024508 1760071 Positive_regulation SELE TNF 25251368 3010088 Positive_regulation SELE TNF 25251368 3010092 Positive_regulation SELE TNF 25349575 1147476 Positive_regulation SELE TNF 25435878 1074855 Positive_regulation SELE TNF 25540945 1654262 Positive_regulation SELE TNF 7507507 1588837 Positive_regulation SELE TNF 7507507 1588840 Positive_regulation SELE TNF 7515891 1435483 Positive_regulation SELE TNF 7682218 1438778 Positive_regulation SELE TNF 7683689 1438789 Positive_regulation SELE TNF 7686390 444172 Positive_regulation SELE TNF 7836926 1592545 Positive_regulation SELE TNF 8386742 1595090 Positive_regulation SELE TNF 8386742 1595093 Positive_regulation SELE TNF 8691131 1598133 Positive_regulation SELE TNF 8691131 1598220 Positive_regulation SELE TNF 9314541 1463950 Positive_regulation SELE TNF 9625761 1602979 Positive_regulation SELE TNF 9888481 448066 Positive_regulation SELE TNF PMC3016539 391066 Positive_regulation SELE TNFSF10 21562052 1637155 Positive_regulation SELL ADAM17 11706054 1276106 Positive_regulation SELL ADAM17 24602331 660685 Positive_regulation SELL ALB 14960177 656390 Positive_regulation SELL AOC3 9254657 1601430 Positive_regulation SELL ARSE 11097205 702044 Positive_regulation SELL CALM3 11785676 702307 Positive_regulation SELL CCL2 12810688 1527674 Positive_regulation SELL CD44 18391078 217644 Positive_regulation SELL CDC73 25013355 1704256 Positive_regulation SELL CDC73 25013355 1704261 Positive_regulation SELL CDC73 25013355 1704266 Positive_regulation SELL CDC73 25013355 1704271 Positive_regulation SELL CDC73 25013355 1704276 Positive_regulation SELL CSF2 2040651 1375876 Positive_regulation SELL CSF2 7512970 1435287 Positive_regulation SELL CSF2 7515891 1435478 Positive_regulation SELL CSF2 7542512 702514 Positive_regulation SELL CTR9 25013355 1704257 Positive_regulation SELL CTR9 25013355 1704262 Positive_regulation SELL CTR9 25013355 1704267 Positive_regulation SELL CTR9 25013355 1704272 Positive_regulation SELL CTR9 25013355 1704277 Positive_regulation SELL DIO1 21298111 2499862 Positive_regulation SELL DIO2 21298111 2499863 Positive_regulation SELL DIO3 21298111 2499864 Positive_regulation SELL DSP 17683640 411721 Positive_regulation SELL ELF4 19412182 1952455 Positive_regulation SELL FOXO1 18978794 1951881 Positive_regulation SELL FOXO1 18978794 1951885 Positive_regulation SELL FOXO1 19808258 1556478 Positive_regulation SELL FOXO1 22654881 901221 Positive_regulation SELL FOXO3 19808258 1556479 Positive_regulation SELL FOXO4 19808258 1556480 Positive_regulation SELL FOXO6 19808258 1556477 Positive_regulation SELL FUT1 8909555 1457678 Positive_regulation SELL FUT10 8909555 1457677 Positive_regulation SELL FUT11 8909555 1457676 Positive_regulation SELL FUT2 8909555 1457679 Positive_regulation SELL FUT3 8909555 1457680 Positive_regulation SELL FUT4 11535629 1520708 Positive_regulation SELL FUT4 14597733 1529406 Positive_regulation SELL FUT4 14597733 1529413 Positive_regulation SELL FUT4 14597733 1529418 Positive_regulation SELL FUT4 8909555 1457681 Positive_regulation SELL FUT5 8909555 1457682 Positive_regulation SELL FUT6 8909555 1457683 Positive_regulation SELL FUT7 11535629 1520709 Positive_regulation SELL FUT7 14597733 1529407 Positive_regulation SELL FUT7 8909555 1457684 Positive_regulation SELL FUT8 8909555 1457685 Positive_regulation SELL FUT9 8909555 1457686 Positive_regulation SELL GAL 10330415 1246422 Positive_regulation SELL HRG PMC4273748 661374 Positive_regulation SELL IFN1@ 7506267 1435148 Positive_regulation SELL IFN1@ 7506267 1435153 Positive_regulation SELL IL12A 24498025 2918212 Positive_regulation SELL IL12A 24498025 2918231 Positive_regulation SELL IL12B 24498025 2918213 Positive_regulation SELL IL12B 24498025 2918232 Positive_regulation SELL IL2 8627168 1596142 Positive_regulation SELL IL6 1281215 1527741 Positive_regulation SELL IL7 23175186 548192 Positive_regulation SELL IRF4 25606598 134102 Positive_regulation SELL ITGAM 20082712 1656069 Positive_regulation SELL ITGB2 11457896 1520000 Positive_regulation SELL KITLG 21931675 2553905 Positive_regulation SELL KLF2 19412182 1952448 Positive_regulation SELL KLF2 21966447 2558003 Positive_regulation SELL LEO1 25013355 1704260 Positive_regulation SELL LEO1 25013355 1704265 Positive_regulation SELL LEO1 25013355 1704270 Positive_regulation SELL LEO1 25013355 1704275 Positive_regulation SELL LEO1 25013355 1704280 Positive_regulation SELL LGALS3 23576987 952936 Positive_regulation SELL MAA 14960177 656391 Positive_regulation SELL MLST8 23183047 1570108 Positive_regulation SELL MMP9 11097210 702107 Positive_regulation SELL MTOR 23183047 1570110 Positive_regulation SELL MTOR PMC2364700 1477128 Positive_regulation SELL P2RX7 15899033 102750 Positive_regulation SELL P2RX7 18404420 3087115 Positive_regulation SELL PAF1 25013355 1704258 Positive_regulation SELL PAF1 25013355 1704263 Positive_regulation SELL PAF1 25013355 1704268 Positive_regulation SELL PAF1 25013355 1704273 Positive_regulation SELL PAF1 25013355 1704278 Positive_regulation SELL PIP PMC2364700 1477126 Positive_regulation SELL PLD1 18404494 3088383 Positive_regulation SELL PLD2 18404494 3088384 Positive_regulation SELL PLD3 18404494 3088379 Positive_regulation SELL PLD4 18404494 3088380 Positive_regulation SELL PLD5 18404494 3088381 Positive_regulation SELL PLD6 18404494 3088382 Positive_regulation SELL PRG2 20140097 2440048 Positive_regulation SELL PRG3 20140097 2440049 Positive_regulation SELL PRG4 20140097 2440050 Positive_regulation SELL RPTOR 23183047 1570109 Positive_regulation SELL SAA1 23626589 906814 Positive_regulation SELL SELE 7530761 1589949 Positive_regulation SELL SELP 7530761 1589946 Positive_regulation SELL SELP 8609175 1451081 Positive_regulation SELL SELP 8642254 1596394 Positive_regulation SELL SELPLG 24127491 1573881 Positive_regulation SELL SETD2 23183047 1570107 Positive_regulation SELL SLPI PMC2364700 1477127 Positive_regulation SELL TDGF1P3 1374413 1297880 Positive_regulation SELL TDGF1P3 1378450 1297957 Positive_regulation SELL TDGF1P3 8627169 1596146 Positive_regulation SELL TLR1 24499202 34904 Positive_regulation SELL TLR10 24499202 34912 Positive_regulation SELL TLR2 23409051 2753326 Positive_regulation SELL TLR2 23409051 2753330 Positive_regulation SELL TLR2 24499202 34905 Positive_regulation SELL TLR3 24499202 34906 Positive_regulation SELL TLR4 24499202 34907 Positive_regulation SELL TLR5 24499202 34908 Positive_regulation SELL TLR6 24499202 34913 Positive_regulation SELL TLR7 24499202 34909 Positive_regulation SELL TLR8 24499202 34910 Positive_regulation SELL TLR9 23409051 2753327 Positive_regulation SELL TLR9 23409051 2753331 Positive_regulation SELL TLR9 24499202 34911 Positive_regulation SELL TNF 11435478 1519735 Positive_regulation SELL TNF 12930553 658490 Positive_regulation SELL TNF 17355628 108154 Positive_regulation SELL TNF 7705312 796394 Positive_regulation SELL TNF 8315391 1594873 Positive_regulation SELL TNF 8340753 1594921 Positive_regulation SELL TNFSF13B 23470998 2086070 Positive_regulation SELL TPO 21931675 2553904 Positive_regulation SELL WDR61 25013355 1704259 Positive_regulation SELL WDR61 25013355 1704264 Positive_regulation SELL WDR61 25013355 1704269 Positive_regulation SELL WDR61 25013355 1704274 Positive_regulation SELL WDR61 25013355 1704279 Positive_regulation SELP ANGPT1 24563688 2924002 Positive_regulation SELP ANGPT1 25371820 1690122 Positive_regulation SELP F2R 18412955 110493 Positive_regulation SELP FUT4 11535629 1520710 Positive_regulation SELP FUT4 14597733 1529414 Positive_regulation SELP FUT4 1717488 1335520 Positive_regulation SELP HES2 20028511 659379 Positive_regulation SELP HES2 20028511 659401 Positive_regulation SELP SELL 8909556 1457694 Positive_regulation SELP SELL 8909556 1457695 Positive_regulation SELP TNF 15642148 102415 Positive_regulation SELP TNF 18475729 1745909 Positive_regulation SELP TNF 19223596 708073 Positive_regulation SELP TNF 20498830 2450921 Positive_regulation SELP TNF 20498830 2450924 Positive_regulation SELP TNF 20498830 2450927 Positive_regulation SELP TNF 21264293 2495217 Positive_regulation SELP TNF 21572963 2520310 Positive_regulation SELP TNF 21572963 2520313 Positive_regulation SELP TNF 21788407 1564369 Positive_regulation SELP TNF 23398879 3210479 Positive_regulation SELP TNF 23962089 1666962 Positive_regulation SELP TNF 25328284 1763076 Positive_regulation SELP TNF 25344627 1722473 Positive_regulation SELP TNF 7683689 1438782 Positive_regulation SELP TNF 7683689 1438783 Positive_regulation SELP TNF 7683689 1438784 Positive_regulation SELP TNF 7683689 1438790 Positive_regulation SELP TNF 7683689 1438793 Positive_regulation SELP TNF 7683689 1438794 Positive_regulation SELP TNF 7683689 1438796 Positive_regulation SELP TNF 8691152 1598549 Positive_regulation SELP TNF 8691152 1598550 Positive_regulation SELPLG ITGB2 23750158 907365 Positive_regulation SELPLG SELL 24127491 1573877 Positive_regulation SELPLG SELL 24127491 1573882 Positive_regulation SELPLG SELL 24127491 1573891 Positive_regulation SEMA3A TLR7 21098092 1561898 Positive_regulation SEMA3A TLR7 21098092 1561934 Positive_regulation SEMA3A TLR7 21098092 1561935 Positive_regulation SEMA3A TNF 21098092 1561648 Positive_regulation SEMA4D EPHB2 15210733 1310275 Positive_regulation SEMA6A TNF 21098092 1561650 Positive_regulation SEMA7A TNF 24550834 963534 Positive_regulation SEPSECS FUT4 9303355 446564 Positive_regulation SEPSECS FUT4 9303355 446575 Positive_regulation SERPINA3 TNF 17822540 395881 Positive_regulation SERPINA3 TNF 24710357 2949680 Positive_regulation SERPINA5 CRK 19936205 2431720 Positive_regulation SERPINA5 SNAP29 21613542 1790717 Positive_regulation SERPINB2 TNF 9607921 1602826 Positive_regulation SERPINB3 EGLN3 22087251 2570743 Positive_regulation SERPINB3 INPP4B 24500884 492407 Positive_regulation SERPINB3 LGALS7B 24515895 492417 Positive_regulation SERPINB3 TNF 18794336 1551996 Positive_regulation SERPINB5 CD14 22570785 1688380 Positive_regulation SERPINB5 F2R 21378407 2175465 Positive_regulation SERPINB5 F2R 21378407 2175477 Positive_regulation SERPINB5 F2R 21378407 2175481 Positive_regulation SERPINB5 F2R 22266725 14439 Positive_regulation SERPINE1 CLU 25148511 3002034 Positive_regulation SERPINE1 CLU 25148511 3002035 Positive_regulation SERPINE1 CLU 25148511 3002037 Positive_regulation SERPINE1 EPHB2 11266465 1269100 Positive_regulation SERPINE1 EPHB2 11266465 1269101 Positive_regulation SERPINE1 EPHB2 11266465 1269127 Positive_regulation SERPINE1 EPHB2 17474984 656548 Positive_regulation SERPINE1 EPHB2 17474984 656586 Positive_regulation SERPINE1 EPHB2 20204159 1671933 Positive_regulation SERPINE1 FOXO1 16287709 1538360 Positive_regulation SERPINE1 IL1B 22220265 1764536 Positive_regulation SERPINE1 MAP2K6 17474984 656592 Positive_regulation SERPINE1 MAP2K6 20204159 1671939 Positive_regulation SERPINE1 PLAT 23977299 2839911 Positive_regulation SERPINE1 PLAT 24564184 290261 Positive_regulation SERPINE1 PLAT 25374584 2007208 Positive_regulation SERPINE1 PLAU 19008962 2400775 Positive_regulation SERPINE1 PLAU 22139533 3177830 Positive_regulation SERPINE1 PLAU 22919385 1674157 Positive_regulation SERPINE1 PLAU 23226636 1044351 Positive_regulation SERPINE1 TNF 14630568 830291 Positive_regulation SERPINE1 TNF 15743490 102685 Positive_regulation SERPINE1 TNF 1714936 1543584 Positive_regulation SERPINE1 TNF 19093006 1908626 Positive_regulation SERPINE1 TNF 19769993 1920550 Positive_regulation SERPINE1 TNF 20356416 1696635 Positive_regulation SERPINE1 TNF 21494547 2512954 Positive_regulation SERPINE1 TNF 21494547 2512957 Positive_regulation SERPINE1 TNF 21494547 2512958 Positive_regulation SERPINE1 TNF 21494547 2512973 Positive_regulation SERPINE1 TNF 21494547 2512975 Positive_regulation SERPINE1 TNF 21569331 1229090 Positive_regulation SERPINE1 TNF 21626291 616670 Positive_regulation SERPINE1 TNF 22111033 730301 Positive_regulation SERPINE1 TNF 22220265 1764535 Positive_regulation SERPINE1 TNF 22355515 2235755 Positive_regulation SERPINE1 TNF 22462016 1151077 Positive_regulation SERPINE1 TNF 22523688 1683319 Positive_regulation SERPINE1 TNF 22745783 2656293 Positive_regulation SERPINE1 TNF 23208413 2110591 Positive_regulation SERPINE1 TNF 23208413 2110592 Positive_regulation SERPINE1 TNF 23785355 878869 Positive_regulation SERPINE1 TNF 23840250 820766 Positive_regulation SERPINE1 TNF 23988189 732585 Positive_regulation SERPINE1 TNF 24148768 220862 Positive_regulation SERPINE1 TNF 24278711 3150250 Positive_regulation SERPINE1 TNF 24286332 222296 Positive_regulation SERPINE1 TNF 24286332 222301 Positive_regulation SERPINE1 TNF 24286332 222303 Positive_regulation SERPINE1 TNF 24707477 188368 Positive_regulation SERPINE1 TNF 24707477 188369 Positive_regulation SERPINE1 TNF 24707477 188370 Positive_regulation SERPINE1 TNF 24707477 188371 Positive_regulation SERPINE1 TNF 24707477 188378 Positive_regulation SERPINE1 TNF 24707477 188379 Positive_regulation SERPINE1 TNF 24707477 188380 Positive_regulation SERPINE1 TNF 24707477 188381 Positive_regulation SERPINE1 TNF 24707477 188395 Positive_regulation SERPINE1 TNF 24707477 188396 Positive_regulation SERPINE1 TNF 24707477 188445 Positive_regulation SERPINE1 TNF 24707477 188475 Positive_regulation SERPINE1 TNF 24707477 188476 Positive_regulation SERPINE1 TNF 24707477 188477 Positive_regulation SERPINE1 TNF 24707477 188478 Positive_regulation SERPINE1 TNF 25276060 1762701 Positive_regulation SERPINE1 TNF 8826848 445619 Positive_regulation SERPINE2 EPHB2 20942929 1859822 Positive_regulation SERPINE2 EPHB2 20942929 1859823 Positive_regulation SERPINE2 MAP2K6 20942929 1859834 Positive_regulation SERPINE2 MAP2K6 20942929 1859835 Positive_regulation SERPINE2 TNF 22028159 3232852 Positive_regulation SERPINF1 CTGF 23055574 1750634 Positive_regulation SERPINF1 TNF 24367624 2900356 Positive_regulation SERPINF1 TNF 24367624 2900361 Positive_regulation SERPINF1 TNF 24367624 2900362 Positive_regulation SERPINF1 TNF 24367624 2900369 Positive_regulation SERPINF1 TNF 24367624 2900370 Positive_regulation SERPINF1 TNF 24367624 2900371 Positive_regulation SERPINF1 TNF 24367624 2900375 Positive_regulation SERPINF1 TNF 24367624 2900376 Positive_regulation SERPINF1 TNF 24367624 2900407 Positive_regulation SERPINF1 TNF 24367624 2900408 Positive_regulation SERPINF1 TNFSF10 22892844 478733 Positive_regulation SERPING1 TNF 24119446 3188654 Positive_regulation SESN3 FOXO1 23614736 830012 Positive_regulation SESN3 FOXO1 23801966 961520 Positive_regulation SETBP1 FAS 16737533 365220 Positive_regulation SETBP1 TNF 20041187 2435874 Positive_regulation SETBP1 TNF 21283748 2497613 Positive_regulation SETBP1 TNF 21283748 2497631 Positive_regulation SETBP1 TNF 21931534 2277143 Positive_regulation SETBP1 TNF 22069676 3183403 Positive_regulation SETBP1 TNF 23282714 3225354 Positive_regulation SETBP1 TNF 23282714 3225359 Positive_regulation SETBP1 TNF 23589093 94847 Positive_regulation SETD2 ANGPT1 18835934 707026 Positive_regulation SETD2 CTGF 22684333 541548 Positive_regulation SETD2 CTGF 22684333 541569 Positive_regulation SETD2 CTGF 22684333 541571 Positive_regulation SETD2 CTGF 22684333 541573 Positive_regulation SETD2 CTGF 23481058 1045252 Positive_regulation SETD2 EGLN3 21709315 2176248 Positive_regulation SETD2 EGLN3 24132642 2009003 Positive_regulation SETD2 EGLN3 24252742 5908 Positive_regulation SETD2 EGLN3 24386269 2903412 Positive_regulation SETD2 EGLN3 25350400 3020219 Positive_regulation SETD2 EPHB2 15987493 103977 Positive_regulation SETD2 EPHB2 18852899 2397596 Positive_regulation SETD2 EPHB2 18852899 2397633 Positive_regulation SETD2 EPHB2 19406746 1165849 Positive_regulation SETD2 EPHB2 21799876 2538918 Positive_regulation SETD2 EPHB2 21980400 2560239 Positive_regulation SETD2 EPHB2 21980400 2560240 Positive_regulation SETD2 EPHB2 21980400 2560257 Positive_regulation SETD2 EPHB2 21980400 2560322 Positive_regulation SETD2 EPHB2 22289741 2179621 Positive_regulation SETD2 EPHB2 22952803 2684104 Positive_regulation SETD2 EPHB2 23282899 3225392 Positive_regulation SETD2 EPHB2 23282899 3225399 Positive_regulation SETD2 EPHB2 23342124 2742491 Positive_regulation SETD2 EPHB2 23342124 2742493 Positive_regulation SETD2 EPHB2 23342124 2742495 Positive_regulation SETD2 EPHB2 23469202 2763188 Positive_regulation SETD2 EPHB2 24556680 572162 Positive_regulation SETD2 FOXO1 21696576 260292 Positive_regulation SETD2 FOXO1 24556689 572294 Positive_regulation SETD2 ID1 18519801 706202 Positive_regulation SETD2 ID1 20003244 254759 Positive_regulation SETD2 ID1 20003244 254761 Positive_regulation SETD2 IL1B 22269218 3101535 Positive_regulation SETD2 IL1B 24470219 978167 Positive_regulation SETD2 MAOA 25198178 3005968 Positive_regulation SETD2 MAOA 25198178 3005970 Positive_regulation SETD2 MAP2K6 22363546 2599822 Positive_regulation SETD2 MAP2K6 23824493 2809090 Positive_regulation SETD2 MUC16 23119050 2712650 Positive_regulation SETD2 NT5E 23423261 1709176 Positive_regulation SETD2 OSR1 18404475 3087792 Positive_regulation SETD2 PGC 22266669 721060 Positive_regulation SETD2 RGS2 25077541 577838 Positive_regulation SETD2 S1PR3 23824493 2809083 Positive_regulation SETD2 S1PR3 23824493 2809121 Positive_regulation SETD2 TLR7 20539755 2452394 Positive_regulation SETD2 TLR7 20539755 2452420 Positive_regulation SETD2 TLR7 20539755 2452443 Positive_regulation SETD2 TLR7 22235182 3152446 Positive_regulation SETD2 TLR7 22870988 126605 Positive_regulation SETD2 TLR7 23282899 3225374 Positive_regulation SETD2 TLR7 24409099 2285261 Positive_regulation SETD2 TLR7 24409099 2285271 Positive_regulation SETD2 TLR7 PMC4088757 661290 Positive_regulation SETD2 TNF 12617740 658460 Positive_regulation SETD2 TNF 17029647 1727732 Positive_regulation SETD2 TNF 19222864 112791 Positive_regulation SETD2 TNF 20404921 2446590 Positive_regulation SETD2 TNF 21298084 2320968 Positive_regulation SETD2 TNF 21298084 2320969 Positive_regulation SETD2 TNF 21298084 2320975 Positive_regulation SETD2 TNF 21298084 2320976 Positive_regulation SETD2 TNF 21298084 2321017 Positive_regulation SETD2 TNF 22621400 412056 Positive_regulation SETD2 TNF 23671580 2792209 Positive_regulation SETD2 TNF 24312355 2888898 Positive_regulation SETD2 TNF 24312355 2888945 Positive_regulation SETD2 TNF 24879546 1730834 Positive_regulation SETD2 TNF 25051011 2991120 Positive_regulation SETD2 TNF 25051011 2991121 Positive_regulation SETD2 TNF 25051011 2991122 Positive_regulation SETD2 TNF 25051011 2991123 Positive_regulation SETD2 TNF 25051011 2991126 Positive_regulation SETD2 TNF 25051011 2991127 Positive_regulation SETD2 TNF 25051011 2991130 Positive_regulation SETD2 TNF 25051011 2991144 Positive_regulation SETD2 TNF 25051011 2991149 Positive_regulation SETD2 TNF 25051011 2991150 Positive_regulation SETD2 TNF 25051011 2991153 Positive_regulation SETD2 TNF 25051011 2991154 Positive_regulation SETD2 TNF 25075575 454105 Positive_regulation SETD2 TNF 25143751 645504 Positive_regulation SETD2 TNF 25258707 200221 Positive_regulation SETD2 TNF 25365172 1133736 Positive_regulation SETD8 TP63 22117221 770915 Positive_regulation SF3B1 IFI27 25569246 3037286 Positive_regulation SF3B1 RNASE1 19443441 2046134 Positive_regulation SF3B2 RNASE1 19443441 2046135 Positive_regulation SF3B3 RNASE1 19443441 2046136 Positive_regulation SF3B4 RNASE1 19443441 2046137 Positive_regulation SF3B5 RNASE1 19443441 2046141 Positive_regulation SF3B5 SMN2 22110043 2070026 Positive_regulation SFI1 NES 15251038 277791 Positive_regulation SFN FOXO1 20642839 1647250 Positive_regulation SFN TNF 21949655 3053476 Positive_regulation SFRP1 WIF1 21083932 330495 Positive_regulation SFRP4 KRT38 18648544 2393535 Positive_regulation SFRP4 PODXL 18648544 2393542 Positive_regulation SFTPB FOXA1 18003659 2031528 Positive_regulation SFTPB TUB 8707828 1453734 Positive_regulation SFTPC KRT38 24244820 205005 Positive_regulation SFTPC TGM2 24244820 204960 Positive_regulation SFXN1 CD14 17242961 810072 Positive_regulation SFXN1 EPHB2 25148033 3001311 Positive_regulation SGPL1 SPHK1 25383881 3024523 Positive_regulation SGPP1 SPHK1 25383881 3024525 Positive_regulation SGPP2 EPHB2 22610094 1203377 Positive_regulation SH2B1 AGR2 22174895 2582475 Positive_regulation SH2D1B FOXO1 19239417 32537 Positive_regulation SH3BP2 TNF 24421967 1675272 Positive_regulation SH3D19 EPHB2 22267161 1967396 Positive_regulation SH3GL2 EPHB2 24736727 2953494 Positive_regulation SHANK1 EPHB2 19547699 2419860 Positive_regulation SHANK2 EPHB2 19547699 2419859 Positive_regulation SHANK3 EPHB2 19547699 2419858 Positive_regulation SHBG TNF 19209274 3176891 Positive_regulation SHC1 EPHB2 15132756 248344 Positive_regulation SHC1 EPHB2 15210733 1310277 Positive_regulation SHC1 EPHB2 18404483 3087880 Positive_regulation SHC1 MAP2K6 18404483 3087886 Positive_regulation SHC1 TCN1 8551221 1595738 Positive_regulation SHE ITGAL 22412848 2609383 Positive_regulation SHH ANGPT1 20098680 2437847 Positive_regulation SHH ANGPT1 22432023 2611613 Positive_regulation SHH ANGPT1 23894369 2824415 Positive_regulation SHH ANGPT1 23894369 2824416 Positive_regulation SHH ANGPT1 23894369 2824425 Positive_regulation SHH CCND1 24451143 1123293 Positive_regulation SHH FOXA1 22988464 3173589 Positive_regulation SHH FOXA1 23383217 2749508 Positive_regulation SHH FOXA1 23383217 2749524 Positive_regulation SHH JAG1 19839776 1236847 Positive_regulation SHH JAG1 19839776 1236890 Positive_regulation SHH JAG1 23028429 2690509 Positive_regulation SHH LRRN2 19602272 1994781 Positive_regulation SHH MAP2K6 23935925 2828421 Positive_regulation SHH MSX1 23316168 960771 Positive_regulation SHH PLAT 22432023 2611589 Positive_regulation SHH PLAT 22432023 2611605 Positive_regulation SHH WIF1 24632949 548647 Positive_regulation SHH WNT7A 18355805 697130 Positive_regulation SHOC2 EPHB2 25514808 3034804 Positive_regulation SI TNF 23238232 651941 Positive_regulation SIAH1 EPHB2 21076532 1674758 Positive_regulation SIAH1 SNCAIP 19399218 1088189 Positive_regulation SIAH2 EPHB2 21076532 1674759 Positive_regulation SIAH3 EPHB2 21076532 1674764 Positive_regulation SIDT1 TMEM100 18565215 372116 Positive_regulation SIDT1 TMEM156 18565215 372134 Positive_regulation SIDT1 TMEM211 18565215 372214 Positive_regulation SIDT1 TMEM213 18565215 372151 Positive_regulation SIGLEC1 TLR7 23593001 3060649 Positive_regulation SIGLEC7 MIP 23029261 2695725 Positive_regulation SIGLEC7 TNF 15996269 1624735 Positive_regulation SIGLEC7 TNF 19570027 137288 Positive_regulation SIGLEC7 TNF 19570027 137330 Positive_regulation SIGLEC7 TNF 23029261 2695722 Positive_regulation SIGLEC9 MUC16 24886523 1874850 Positive_regulation SIGLEC9 TNF 23029261 2695731 Positive_regulation SIL1 TNF 24498365 2919258 Positive_regulation SIN3A EPHB2 16262446 2258783 Positive_regulation SIN3A FOXO1 25329053 2365573 Positive_regulation SIN3A NES 24552625 2013117 Positive_regulation SIN3A TNF 7931061 1593049 Positive_regulation SIRT1 ALDH2 24040162 2846027 Positive_regulation SIRT1 ALDH2 24040162 2846030 Positive_regulation SIRT1 ALDH2 24040162 2846033 Positive_regulation SIRT1 FOXO1 21422498 29391 Positive_regulation SIRT1 FOXO1 21566744 3188809 Positive_regulation SIRT1 FOXO1 22156377 30032 Positive_regulation SIRT1 FOXO1 24069505 2226991 Positive_regulation SIRT1 FOXO1 25136826 2998909 Positive_regulation SIRT1 FOXO1 25360511 2119076 Positive_regulation SIRT1 GLP1R 22950055 730415 Positive_regulation SIRT1 PGC 21076574 1710262 Positive_regulation SIRT1 PGC 21113404 3075685 Positive_regulation SIRT1 PGC 21614150 1057218 Positive_regulation SIRT1 PGC 21629705 1155255 Positive_regulation SIRT1 PGC 22254041 2115991 Positive_regulation SIRT1 PGC 22622703 142903 Positive_regulation SIRT1 PGC 22742579 292134 Positive_regulation SIRT1 PGC 22829833 1068687 Positive_regulation SIRT1 PGC 22969827 815222 Positive_regulation SIRT1 PGC 24077237 2118224 Positive_regulation SIRT1 PGC 24567900 1887680 Positive_regulation SIRT1 PGC 24990154 3144002 Positive_regulation SIRT1 TNF 22069489 2569150 Positive_regulation SIRT1 TNF 22447223 14581 Positive_regulation SIRT1 TNF 22447223 14598 Positive_regulation SIRT1 TNF 24498364 2919253 Positive_regulation SIRT2 FOXO1 23417962 780047 Positive_regulation SIRT3 PGC 20661474 2456747 Positive_regulation SIRT3 PGC 20661474 2456748 Positive_regulation SIRT3 PGC 20661474 2456749 Positive_regulation SIRT3 PGC 20661474 2456750 Positive_regulation SIRT3 PGC 20661474 2456751 Positive_regulation SIRT3 PGC 20661474 2456760 Positive_regulation SIRT3 PGC 20661474 2456761 Positive_regulation SIRT3 PGC 20661474 2456762 Positive_regulation SIRT3 PGC 20661474 2456764 Positive_regulation SIRT3 PGC 20661474 2456765 Positive_regulation SIRT3 PGC 20661474 2456766 Positive_regulation SIRT3 PGC 20661474 2456770 Positive_regulation SIRT3 PGC 20661474 2456771 Positive_regulation SIRT3 PGC 20661474 2456772 Positive_regulation SIRT3 PGC 20661474 2456776 Positive_regulation SIRT3 PGC 20661474 2456782 Positive_regulation SIRT3 PGC 20661474 2456783 Positive_regulation SIRT3 PGC 20661474 2456784 Positive_regulation SIRT3 PGC 20661474 2456785 Positive_regulation SIRT3 PGC 20661474 2456788 Positive_regulation SIRT3 PGC 21901160 2550242 Positive_regulation SIRT3 PGC 23075607 30916 Positive_regulation SIRT3 PGC 23166782 2718946 Positive_regulation SIRT3 PGC 23166782 2719068 Positive_regulation SIRT3 PGC 23800187 1868859 Positive_regulation SIRT3 PGC 23840225 1156411 Positive_regulation SIRT3 PGC 24046746 858684 Positive_regulation SIRT3 PGC 24046746 858691 Positive_regulation SIRT3 PGC 24069505 2226964 Positive_regulation SIRT3 PGC 24480485 452241 Positive_regulation SIRT3 PGC 24503539 571948 Positive_regulation SIRT3 PGC 24672550 1070691 Positive_regulation SIRT3 PGC 24743600 2955654 Positive_regulation SIRT3 PGC 24837835 1126955 Positive_regulation SIRT6 TNF 21738489 2325069 Positive_regulation SIRT6 TNF 21738489 2325083 Positive_regulation SIRT6 TNF 21738489 2325084 Positive_regulation SIX1 CCND1 23527134 2769580 Positive_regulation SIX1 CCND1 23527134 2769581 Positive_regulation SIX1 CCND1 23527134 2769585 Positive_regulation SIX1 EPHB2 22765220 471667 Positive_regulation SIX1 EPHB2 22765220 471727 Positive_regulation SIX1 MAP2K6 22765220 471673 Positive_regulation SKAP1 ITGAL 21669874 1192238 Positive_regulation SKIV2L MAP2K6 23818902 2119906 Positive_regulation SKP1 ABCG2 22252524 3204977 Positive_regulation SKP1 EPHB2 21559359 2518491 Positive_regulation SKP2 IFI27 19149897 401629 Positive_regulation SKP2 IFI27 22558406 2625558 Positive_regulation SKP2 IFI27 22733130 2147473 Positive_regulation SKP2 IFI27 23226679 941535 Positive_regulation SKP2 IFI27 23226679 941568 Positive_regulation SKP2 IFI27 24971481 548954 Positive_regulation SKP2 IFI27 24971481 549039 Positive_regulation SKP2 TNF 23255047 605218 Positive_regulation SLAMF1 TLR7 23882270 908270 Positive_regulation SLAMF7 TNF 17069659 312959 Positive_regulation SLC10A2 GLP1R 22933116 724473 Positive_regulation SLC10A2 GLP1R 22933116 724474 Positive_regulation SLC10A3 TNF 17304338 1054720 Positive_regulation SLC11A2 TNF 24920275 2213771 Positive_regulation SLC12A2 EPHB2 25342941 685444 Positive_regulation SLC12A2 OSR1 24555568 1871847 Positive_regulation SLC12A2 OSR1 24555568 1871862 Positive_regulation SLC12A2 TNF 24916922 1668183 Positive_regulation SLC12A2 TNF 24916922 1668186 Positive_regulation SLC12A2 TNF 24916922 1668194 Positive_regulation SLC12A3 OSR1 24761002 84862 Positive_regulation SLC12A5 CAPN8 24567703 868759 Positive_regulation SLC12A5 EPHB2 22084630 860766 Positive_regulation SLC12A6 OSR1 24393035 152287 Positive_regulation SLC12A9 CCND1 20180967 584469 Positive_regulation SLC12A9 CCND1 22481926 1673477 Positive_regulation SLC12A9 CCND1 23300840 2736184 Positive_regulation SLC12A9 CCND1 25477755 657796 Positive_regulation SLC16A3 BSG 20454640 1215234 Positive_regulation SLC16A3 BSG 25314297 1131947 Positive_regulation SLC16A3 SETD2 24363178 606910 Positive_regulation SLC16A6 ARSG 24454846 2910141 Positive_regulation SLC17A5 SYNM 21103082 2114982 Positive_regulation SLC17A5 SYNM 22811744 814851 Positive_regulation SLC1A2 EPHB2 24376419 953408 Positive_regulation SLC1A2 MIP 23234294 1665474 Positive_regulation SLC1A2 MIP 23234294 1665478 Positive_regulation SLC1A2 SLC1A6 17713594 831100 Positive_regulation SLC1A2 TNF 24119288 1895849 Positive_regulation SLC1A2 TNF 24966471 1759850 Positive_regulation SLC1A2 TNF 25371754 845419 Positive_regulation SLC1A2 TNF 25371754 845422 Positive_regulation SLC1A6 SLC1A2 17713594 831102 Positive_regulation SLC22A3 CCND1 18945340 2001046 Positive_regulation SLC22A3 CCND1 23284982 2731401 Positive_regulation SLC22A3 CEACAM6 25398131 3027578 Positive_regulation SLC22A3 CEACAM6 25398131 3027588 Positive_regulation SLC22A3 CEACAM6 25398131 3027605 Positive_regulation SLC22A3 CEACAM6 25398131 3027606 Positive_regulation SLC22A3 CTGF 21986574 13478 Positive_regulation SLC22A3 CTGF 23259759 856344 Positive_regulation SLC22A3 CTGF 23755163 2801560 Positive_regulation SLC22A3 EPHB2 20821804 774977 Positive_regulation SLC22A3 EPHB2 22030022 468817 Positive_regulation SLC22A3 EPHB2 22110740 2573137 Positive_regulation SLC22A3 EPHB2 22765220 471700 Positive_regulation SLC22A3 EPHB2 23157946 266948 Positive_regulation SLC22A3 EPHB2 24168056 1700765 Positive_regulation SLC22A3 EPHB2 24550739 2356972 Positive_regulation SLC22A3 EPHB2 24586454 2924952 Positive_regulation SLC22A3 EPHB2 24678619 396464 Positive_regulation SLC22A3 EPHB2 25337707 3018320 Positive_regulation SLC22A3 EPHB2 25367335 626595 Positive_regulation SLC22A3 EPHB2 25538889 949160 Positive_regulation SLC22A3 F2R 23919450 834017 Positive_regulation SLC22A3 F2R 23919450 834022 Positive_regulation SLC22A3 FAS 25333257 2205557 Positive_regulation SLC22A3 FOXQ1 22453032 412040 Positive_regulation SLC22A3 FOXQ1 22761930 2659246 Positive_regulation SLC22A3 FOXQ1 23203039 1099494 Positive_regulation SLC22A3 FOXQ1 25356753 2206481 Positive_regulation SLC22A3 FOXQ1 25356753 2206482 Positive_regulation SLC22A3 FOXQ1 25356753 2206497 Positive_regulation SLC22A3 FUT4 23887626 564145 Positive_regulation SLC22A3 FUT4 23887626 564151 Positive_regulation SLC22A3 ID1 23555842 2775508 Positive_regulation SLC22A3 ID1 23555842 2775522 Positive_regulation SLC22A3 ID1 24137437 2165753 Positive_regulation SLC22A3 ID1 24970809 2193983 Positive_regulation SLC22A3 JAG1 17984306 1547501 Positive_regulation SLC22A3 JAG1 20691079 257032 Positive_regulation SLC22A3 JAG1 23056328 2701182 Positive_regulation SLC22A3 JAG1 23531541 1103797 Positive_regulation SLC22A3 JAG1 23531541 1103798 Positive_regulation SLC22A3 JAG1 23560082 2776401 Positive_regulation SLC22A3 KLF9 21324165 259199 Positive_regulation SLC22A3 MAP2K6 21383698 2138586 Positive_regulation SLC22A3 MAP2K6 21383698 2138607 Positive_regulation SLC22A3 MAP2K6 22432005 2611499 Positive_regulation SLC22A3 MAP2K6 22765220 471706 Positive_regulation SLC22A3 MMP28 16301332 1325493 Positive_regulation SLC22A3 MMP28 16301332 1325523 Positive_regulation SLC22A3 MMP28 16301332 1325524 Positive_regulation SLC22A3 MMP28 19375502 1731684 Positive_regulation SLC22A3 MMP28 20440544 1639548 Positive_regulation SLC22A3 MMP28 20440544 1639572 Positive_regulation SLC22A3 MMP28 21843314 1505496 Positive_regulation SLC22A3 MMP28 24811539 2190968 Positive_regulation SLC22A3 MMP28 25050175 652264 Positive_regulation SLC22A3 MMP7 16301332 1325508 Positive_regulation SLC22A3 MMP7 16301332 1325553 Positive_regulation SLC22A3 MMP7 16301332 1325554 Positive_regulation SLC22A3 MMP7 20440544 1639563 Positive_regulation SLC22A3 MMP7 20440544 1639587 Positive_regulation SLC22A3 MMP7 20584780 1023279 Positive_regulation SLC22A3 MMP7 24811539 2190983 Positive_regulation SLC22A3 MMP7 25050175 652279 Positive_regulation SLC22A3 MUC16 21326240 436472 Positive_regulation SLC22A3 MUC16 21326240 436473 Positive_regulation SLC22A3 MUC16 21326240 436474 Positive_regulation SLC22A3 MUC16 21326240 436489 Positive_regulation SLC22A3 NEDD9 21829474 2541144 Positive_regulation SLC22A3 NEDD9 21829474 2541145 Positive_regulation SLC22A3 NEDD9 21829474 2541146 Positive_regulation SLC22A3 NEDD9 21829474 2541147 Positive_regulation SLC22A3 NEDD9 21829474 2541156 Positive_regulation SLC22A3 NEDD9 21829474 2541158 Positive_regulation SLC22A3 NEDD9 21829474 2541159 Positive_regulation SLC22A3 PIGR 22025622 1651607 Positive_regulation SLC22A3 PIGR 22025622 1651608 Positive_regulation SLC22A3 PIGR 22025622 1651609 Positive_regulation SLC22A3 PIGR 22025622 1651610 Positive_regulation SLC22A3 PIGR 22025622 1651611 Positive_regulation SLC22A3 PIGR 22025622 1651660 Positive_regulation SLC22A3 PIGR 22025622 1651661 Positive_regulation SLC22A3 PIGR 22025622 1651662 Positive_regulation SLC22A3 PIGR 22025622 1651663 Positive_regulation SLC22A3 PIGR 22025622 1651685 Positive_regulation SLC22A3 PIGR 22025622 1651686 Positive_regulation SLC22A3 PIGR 22025622 1651687 Positive_regulation SLC22A3 PIGR 22025622 1651689 Positive_regulation SLC22A3 PIGR 22025622 1651723 Positive_regulation SLC22A3 PLAU 23984088 1150904 Positive_regulation SLC22A3 PLAU 23984088 1150955 Positive_regulation SLC22A3 PLAU 23984088 1150986 Positive_regulation SLC22A3 PODXL 21533279 2515788 Positive_regulation SLC22A3 STK39 24816813 2963156 Positive_regulation SLC22A3 TGM2 21943122 1863479 Positive_regulation SLC22A3 TGM2 22566887 899613 Positive_regulation SLC22A3 TMPRSS4 24168056 1700785 Positive_regulation SLC22A3 TMPRSS4 24748857 1021888 Positive_regulation SLC22A3 TMPRSS4 24748857 1021906 Positive_regulation SLC22A3 TNF 15946381 3105028 Positive_regulation SLC22A3 TNF 15946381 3105056 Positive_regulation SLC22A3 TNF 20049734 774449 Positive_regulation SLC22A3 TNF 21147546 2220571 Positive_regulation SLC22A3 TNF 21664353 829208 Positive_regulation SLC22A3 TNF 21841813 13267 Positive_regulation SLC22A3 TNF 21880137 519990 Positive_regulation SLC22A3 TNF 21880137 519993 Positive_regulation SLC22A3 TNF 21880181 623929 Positive_regulation SLC22A3 TNF 22187661 1082421 Positive_regulation SLC22A3 TNF 22315958 469764 Positive_regulation SLC22A3 TNF 22694981 396370 Positive_regulation SLC22A3 TNF 22938142 358624 Positive_regulation SLC22A3 TNF 23108409 2148989 Positive_regulation SLC22A3 TNF 23243599 2161905 Positive_regulation SLC22A3 TNF 23263670 1100104 Positive_regulation SLC22A3 TNF 23300891 2737183 Positive_regulation SLC22A3 TNF 23300891 2737187 Positive_regulation SLC22A3 TNF 23300891 2737211 Positive_regulation SLC22A3 TNF 23437179 2755897 Positive_regulation SLC22A3 TNF 23437179 2755898 Positive_regulation SLC22A3 TNF 23437179 2755899 Positive_regulation SLC22A3 TNF 23437179 2755934 Positive_regulation SLC22A3 TNF 23437179 2755939 Positive_regulation SLC22A3 TNF 23441172 2756965 Positive_regulation SLC22A3 TNF 23441172 2756970 Positive_regulation SLC22A3 TNF 23935876 2828146 Positive_regulation SLC22A3 TNF 23935876 2828161 Positive_regulation SLC22A3 TNF 23935876 2828164 Positive_regulation SLC22A3 TNF 24009024 1111040 Positive_regulation SLC22A3 TNF 24250816 2881726 Positive_regulation SLC22A3 TNF 24281219 502422 Positive_regulation SLC22A3 TNF 24283210 3114240 Positive_regulation SLC22A3 TNF 24386633 186135 Positive_regulation SLC22A3 TNF 24386633 186138 Positive_regulation SLC22A3 TNF 24762633 504510 Positive_regulation SLC22A3 TNF 24811539 2190960 Positive_regulation SLC22A3 TNF 24901008 1621686 Positive_regulation SLC22A3 WNT7A 23284647 2730370 Positive_regulation SLC23A2 SLC23A1 25110615 1691203 Positive_regulation SLC25A16 PLAU 11266465 1269119 Positive_regulation SLC25A20 TLR7 19551144 2419920 Positive_regulation SLC26A5 EDN2 23197953 515492 Positive_regulation SLC27A5 LBP 19718443 2425454 Positive_regulation SLC27A5 TNF 21040544 3111636 Positive_regulation SLC27A5 TNF 24069158 2851650 Positive_regulation SLC28A1 AKT1 23722537 562001 Positive_regulation SLC28A1 AKT2 23722537 562002 Positive_regulation SLC28A1 AKT3 23722537 562003 Positive_regulation SLC29A1 NT5E 23437309 2756414 Positive_regulation SLC29A1 NT5E 23437309 2756415 Positive_regulation SLC2A1 EPHB2 25474091 1135572 Positive_regulation SLC2A1 WNT7A 20150991 1161100 Positive_regulation SLC2A2 FOXO1 22399922 3158695 Positive_regulation SLC2A4 AXIN2 22473005 610488 Positive_regulation SLC2A4 EPHB2 20231899 2443126 Positive_regulation SLC2A4 PGC 21475702 1238372 Positive_regulation SLC2A4 PGC 22359576 2597723 Positive_regulation SLC2A4 PGC 23538842 1104175 Positive_regulation SLC2A4 PGC 23639108 213508 Positive_regulation SLC2A4 PGC 24199159 730982 Positive_regulation SLC2A4 PGC 25136584 197213 Positive_regulation SLC2A4 PGC 25170305 1063272 Positive_regulation SLC2A4 RAB31 22470488 2614344 Positive_regulation SLC2A4 RAB31 24611020 731572 Positive_regulation SLC2A4 TNF 20414465 1747457 Positive_regulation SLC2A4 TNF 23917668 653567 Positive_regulation SLC2A4 TNF 24324517 824425 Positive_regulation SLC2A4 TNF 24416415 2908730 Positive_regulation SLC2A4 TNF 24416415 2908751 Positive_regulation SLC2A4RG RAB31 22977732 2209349 Positive_regulation SLC2A4RG RAB31 23696742 3061543 Positive_regulation SLC2A4RG TLR7 22231169 1928184 Positive_regulation SLC2A4RG TNF 23789107 169919 Positive_regulation SLC33A1 CLU 25148511 3002038 Positive_regulation SLC33A1 EPHB2 17319972 1645366 Positive_regulation SLC33A1 EPHB2 22904641 490810 Positive_regulation SLC33A1 EPHB2 23300732 2735656 Positive_regulation SLC33A1 EPHB2 24918049 853810 Positive_regulation SLC33A1 TNF 23056347 2701294 Positive_regulation SLC33A1 TNF 24788542 2959145 Positive_regulation SLC33A1 TNF 25574467 202394 Positive_regulation SLC39A8 TNF 23304467 1669944 Positive_regulation SLC39A8 TNF 23304467 1669945 Positive_regulation SLC39A8 TNF 23738776 213607 Positive_regulation SLC44A1 FAS 24578708 1070413 Positive_regulation SLC4A2 MAP2K6 19823673 2428263 Positive_regulation SLC4A3 CA12 23297731 275170 Positive_regulation SLC5A7 TNF 22563552 89161 Positive_regulation SLC6A12 EPHB2 20800688 2222093 Positive_regulation SLC6A2 ANG 8978826 1458491 Positive_regulation SLC6A2 CASP3 24307893 980697 Positive_regulation SLC6A2 CASP3 24307893 980711 Positive_regulation SLC6A2 CDC123 18762578 1356460 Positive_regulation SLC6A2 CDC16 18762578 1356462 Positive_regulation SLC6A2 CDC20 18762578 1356463 Positive_regulation SLC6A2 CDC23 18762578 1356464 Positive_regulation SLC6A2 CDC26 18762578 1356473 Positive_regulation SLC6A2 CDC27 18762578 1356465 Positive_regulation SLC6A2 CDC34 18762578 1356466 Positive_regulation SLC6A2 CDC37 18762578 1356467 Positive_regulation SLC6A2 CDC40 18762578 1356468 Positive_regulation SLC6A2 CDC42 18762578 1356469 Positive_regulation SLC6A2 CDC45 18762578 1356470 Positive_regulation SLC6A2 CDC5L 11960554 368747 Positive_regulation SLC6A2 CDC5L 11960554 368935 Positive_regulation SLC6A2 CDC5L 11960554 368983 Positive_regulation SLC6A2 CDC5L 22383977 2602576 Positive_regulation SLC6A2 CDC6 18762578 1356471 Positive_regulation SLC6A2 CDC7 18762578 1356472 Positive_regulation SLC6A2 CDC73 18762578 1356459 Positive_regulation SLC6A2 CDK1 24339788 2353361 Positive_regulation SLC6A2 CDK2 18762578 1356298 Positive_regulation SLC6A2 CDK2 18762578 1356419 Positive_regulation SLC6A2 CDK2 18762578 1356695 Positive_regulation SLC6A2 CDK2 18762578 1356696 Positive_regulation SLC6A2 CDK2 18845253 686686 Positive_regulation SLC6A2 CDK2 18845253 686687 Positive_regulation SLC6A2 CDK2 18845253 686754 Positive_regulation SLC6A2 CDK2 18845253 686860 Positive_regulation SLC6A2 CDK2 21690308 1389384 Positive_regulation SLC6A2 CDK2 22383977 2602792 Positive_regulation SLC6A2 ESPL1 18762578 1356461 Positive_regulation SLC6A2 ESPL1 24339788 2353360 Positive_regulation SLC6A2 LPA 18827818 431399 Positive_regulation SLC6A2 PLK1 11960554 368751 Positive_regulation SLC6A2 PLK2 11960554 368748 Positive_regulation SLC6A2 PLK3 11960554 368749 Positive_regulation SLC6A2 PLK4 11960554 368746 Positive_regulation SLC6A2 PLK5 11960554 368750 Positive_regulation SLC6A2 SLC25A33 20947565 2057626 Positive_regulation SLC6A4 TNF 20026656 1369794 Positive_regulation SLC6A4 TNF 21485745 734859 Positive_regulation SLC7A1 PGC 23326623 2225409 Positive_regulation SLC7A7 RNASE1 23662044 742640 Positive_regulation SLC7A7 RNASE7 23662044 742648 Positive_regulation SLC9A1 CA12 23297731 275183 Positive_regulation SLC9A1 EPHB2 22904641 490796 Positive_regulation SLC9A2 EGR1 24376510 2900971 Positive_regulation SLC9A2 EGR1 24376510 2900972 Positive_regulation SLC9A2 EGR1 24376510 2900983 Positive_regulation SLC9A2 EGR1 24376510 2900986 Positive_regulation SLC9A3 SLC9A2 17498647 157286 Positive_regulation SLC9A3R1 FZD4 20802536 2135925 Positive_regulation SLC9A3R1 PDZK1 20237154 1775193 Positive_regulation SLC9A3R1 PDZK1 20237154 1775199 Positive_regulation SLC9A3R1 PDZK1 20237154 1775203 Positive_regulation SLC9A3R1 PODXL 17311105 2374665 Positive_regulation SLC9A3R1 PODXL 17311105 2374666 Positive_regulation SLC9A3R1 PODXL 19889841 1770849 Positive_regulation SLCO2A1 CA2 24065885 867528 Positive_regulation SLCO2A1 CAT 23451175 2758305 Positive_regulation SLCO2A1 RENBP 22675339 833114 Positive_regulation SLCO2A1 RNPEP 24399942 921980 Positive_regulation SLCO2A1 SOD1 23451175 2758302 Positive_regulation SLCO2A1 SOD2 23451175 2758303 Positive_regulation SLCO2A1 SOD3 23451175 2758304 Positive_regulation SLCO3A1 EPHB2 24945726 2981558 Positive_regulation SLCO6A1 AGR2 23451091 2757748 Positive_regulation SLCO6A1 EPHB2 20865152 2291850 Positive_regulation SLCO6A1 EPHB2 9432981 1602419 Positive_regulation SLCO6A1 FOXO1 24314125 33273 Positive_regulation SLCO6A1 MAP2K6 22569127 771789 Positive_regulation SLCO6A1 MAP2K6 23603961 2254740 Positive_regulation SLCO6A1 RNASE1 19443441 2046143 Positive_regulation SLCO6A1 RNASE1 19729507 2047379 Positive_regulation SLCO6A1 RNASE1 22730292 2078967 Positive_regulation SLCO6A1 RNASE7 19729507 2047387 Positive_regulation SLCO6A1 TNF 17567906 370596 Positive_regulation SLCO6A1 TNF 17567906 370604 Positive_regulation SLCO6A1 TNF 17567906 370618 Positive_regulation SLCO6A1 TNF 17567906 370637 Positive_regulation SLCO6A1 TNF 24386331 2903501 Positive_regulation SLCO6A1 TNF 24386331 2903533 Positive_regulation SLFN11 CCND1 25329797 3016319 Positive_regulation SLFN12 CCND1 25329797 3016317 Positive_regulation SLFN13 CCND1 25329797 3016318 Positive_regulation SLFN14 CCND1 25329797 3016321 Positive_regulation SLFN5 CCND1 25329797 3016320 Positive_regulation SLPI CCND1 18501024 1655515 Positive_regulation SLPI EPHB2 21437254 2509175 Positive_regulation SLPI EPHB2 21437254 2509183 Positive_regulation SLPI NPNT 19844573 2428920 Positive_regulation SLPI TF 1892746 431436 Positive_regulation SLPI TGM2 21687692 2528895 Positive_regulation SLPI TNF 10449524 1512270 Positive_regulation SLPI TNF 21437254 2509174 Positive_regulation SMAD1 CTGF 21541658 616632 Positive_regulation SMAD1 CTGF 21760921 2535983 Positive_regulation SMAD1 CTGF 21760921 2535991 Positive_regulation SMAD1 CTGF 21760921 2535993 Positive_regulation SMAD1 CTGF 21760921 2536012 Positive_regulation SMAD1 CTGF 21931601 2553632 Positive_regulation SMAD1 CTGF 22918238 541767 Positive_regulation SMAD1 CTGF 24090133 537711 Positive_regulation SMAD1 EPHB2 19821774 1236708 Positive_regulation SMAD1 EPHB2 22539964 2622630 Positive_regulation SMAD1 EPHB2 22593733 930623 Positive_regulation SMAD1 EPHB2 22593733 930661 Positive_regulation SMAD1 EPHB2 23028582 2691693 Positive_regulation SMAD1 FOXO1 24145170 1411713 Positive_regulation SMAD1 FOXO1 25423188 3030098 Positive_regulation SMAD1 ID1 15877825 350608 Positive_regulation SMAD1 NES 24625091 272362 Positive_regulation SMAD1 PIGR 22025622 1651612 Positive_regulation SMAD1 PIGR 22025622 1651613 Positive_regulation SMAD1 PIGR 22025622 1651614 Positive_regulation SMAD1 PIGR 22025622 1651665 Positive_regulation SMAD1 PIGR 22025622 1651690 Positive_regulation SMAD1 PIGR 22025622 1651691 Positive_regulation SMAD1 PIGR 22025622 1651692 Positive_regulation SMAD1 PIGR 22025622 1651724 Positive_regulation SMAD1 PIGR 22025622 1651734 Positive_regulation SMAD1 STK39 21789165 2537657 Positive_regulation SMAD1 STK39 23029472 2697719 Positive_regulation SMAD1 TF 24409331 2906993 Positive_regulation SMAD1 TNF 24743742 573864 Positive_regulation SMAD2 CAPN8 PMC3329082 3086574 Positive_regulation SMAD2 CLU 23157228 230281 Positive_regulation SMAD2 CTGF 21541658 616634 Positive_regulation SMAD2 CTGF 21931601 2553633 Positive_regulation SMAD2 CTGF 22363627 2601348 Positive_regulation SMAD2 CTGF 22988467 1156212 Positive_regulation SMAD2 CTGF 23383241 2749628 Positive_regulation SMAD2 CTGF 23441194 2757016 Positive_regulation SMAD2 EPHB2 16390551 3106000 Positive_regulation SMAD2 EPHB2 21572418 1925866 Positive_regulation SMAD2 EPHB2 21860657 813113 Positive_regulation SMAD2 EPHB2 21860657 813115 Positive_regulation SMAD2 EPHB2 21860657 813145 Positive_regulation SMAD2 EPHB2 22539964 2622631 Positive_regulation SMAD2 EPHB2 23028582 2691694 Positive_regulation SMAD2 FOXO1 24145170 1411714 Positive_regulation SMAD2 FOXO1 25423188 3030099 Positive_regulation SMAD2 HES2 20876311 1560360 Positive_regulation SMAD2 ID1 15877825 350610 Positive_regulation SMAD2 NES 24625091 272363 Positive_regulation SMAD2 PIGR 22025622 1651615 Positive_regulation SMAD2 PIGR 22025622 1651616 Positive_regulation SMAD2 PIGR 22025622 1651617 Positive_regulation SMAD2 PIGR 22025622 1651667 Positive_regulation SMAD2 PIGR 22025622 1651668 Positive_regulation SMAD2 PIGR 22025622 1651693 Positive_regulation SMAD2 PIGR 22025622 1651694 Positive_regulation SMAD2 PIGR 22025622 1651695 Positive_regulation SMAD2 PIGR 22025622 1651725 Positive_regulation SMAD2 PIGR 22025622 1651735 Positive_regulation SMAD2 STK39 21789165 2537681 Positive_regulation SMAD2 STK39 23029472 2697734 Positive_regulation SMAD2 TF 24409331 2906995 Positive_regulation SMAD2 TNF 19087346 3109086 Positive_regulation SMAD2 TNF 19087346 3109087 Positive_regulation SMAD2 TNF 22313861 3160886 Positive_regulation SMAD2 TNF 22313861 3160952 Positive_regulation SMAD2 TNF 22313861 3160976 Positive_regulation SMAD2 TNF 22476871 1238678 Positive_regulation SMAD2 TNF 22476871 1238688 Positive_regulation SMAD2 TNF 23437179 2755925 Positive_regulation SMAD2 TNF 24743742 573866 Positive_regulation SMAD3 CAPN8 PMC3329082 3086589 Positive_regulation SMAD3 CLU 23157228 230282 Positive_regulation SMAD3 CLU 25148511 3002033 Positive_regulation SMAD3 CTGF 21541658 616636 Positive_regulation SMAD3 CTGF 21931601 2553634 Positive_regulation SMAD3 CTGF 22363627 2601350 Positive_regulation SMAD3 CTGF 23516540 2768409 Positive_regulation SMAD3 EPHB2 16390551 3106003 Positive_regulation SMAD3 EPHB2 21572418 1925867 Positive_regulation SMAD3 EPHB2 21860657 813114 Positive_regulation SMAD3 EPHB2 21860657 813116 Positive_regulation SMAD3 EPHB2 21860657 813146 Positive_regulation SMAD3 EPHB2 22539964 2622632 Positive_regulation SMAD3 EPHB2 22927969 2681228 Positive_regulation SMAD3 EPHB2 23028582 2691695 Positive_regulation SMAD3 FOXO1 24145170 1411715 Positive_regulation SMAD3 FOXO1 25423188 3030100 Positive_regulation SMAD3 HES2 20876311 1560368 Positive_regulation SMAD3 ID1 15877825 350612 Positive_regulation SMAD3 ID1 20565867 1856137 Positive_regulation SMAD3 JAG1 24324509 639337 Positive_regulation SMAD3 NEDD9 15144564 277554 Positive_regulation SMAD3 NES 24625091 272364 Positive_regulation SMAD3 PIGR 22025622 1651618 Positive_regulation SMAD3 PIGR 22025622 1651619 Positive_regulation SMAD3 PIGR 22025622 1651620 Positive_regulation SMAD3 PIGR 22025622 1651670 Positive_regulation SMAD3 PIGR 22025622 1651671 Positive_regulation SMAD3 PIGR 22025622 1651696 Positive_regulation SMAD3 PIGR 22025622 1651697 Positive_regulation SMAD3 PIGR 22025622 1651698 Positive_regulation SMAD3 PIGR 22025622 1651726 Positive_regulation SMAD3 PIGR 22025622 1651736 Positive_regulation SMAD3 S1PR3 24970177 208714 Positive_regulation SMAD3 S1PR3 25198418 3005991 Positive_regulation SMAD3 STK39 21789165 2537705 Positive_regulation SMAD3 STK39 23029472 2697749 Positive_regulation SMAD3 TF 24409331 2906997 Positive_regulation SMAD3 TNF 22313861 3160954 Positive_regulation SMAD3 TNF 22476871 1238681 Positive_regulation SMAD3 TNF 22476871 1238693 Positive_regulation SMAD3 TNF 24004852 803465 Positive_regulation SMAD3 TNF 24743742 573868 Positive_regulation SMAD4 CTGF 21541658 616638 Positive_regulation SMAD4 CTGF 21931601 2553635 Positive_regulation SMAD4 EPHB2 21572418 1925868 Positive_regulation SMAD4 EPHB2 21860657 813147 Positive_regulation SMAD4 EPHB2 22539964 2622633 Positive_regulation SMAD4 EPHB2 23028582 2691696 Positive_regulation SMAD4 FOXO1 24145170 1411716 Positive_regulation SMAD4 FOXO1 25423188 3030101 Positive_regulation SMAD4 ID1 15877825 350614 Positive_regulation SMAD4 NES 24625091 272365 Positive_regulation SMAD4 PIGR 22025622 1651621 Positive_regulation SMAD4 PIGR 22025622 1651622 Positive_regulation SMAD4 PIGR 22025622 1651623 Positive_regulation SMAD4 PIGR 22025622 1651673 Positive_regulation SMAD4 PIGR 22025622 1651699 Positive_regulation SMAD4 PIGR 22025622 1651700 Positive_regulation SMAD4 PIGR 22025622 1651701 Positive_regulation SMAD4 PIGR 22025622 1651727 Positive_regulation SMAD4 PIGR 22025622 1651737 Positive_regulation SMAD4 STK39 21789165 2537729 Positive_regulation SMAD4 STK39 23029472 2697764 Positive_regulation SMAD4 TF 24409331 2906999 Positive_regulation SMAD4 TNF 24743742 573870 Positive_regulation SMAD5 CTGF 21541658 616640 Positive_regulation SMAD5 CTGF 21931601 2553636 Positive_regulation SMAD5 CTGF 22918238 541768 Positive_regulation SMAD5 EPHB2 22539964 2622634 Positive_regulation SMAD5 EPHB2 23028582 2691697 Positive_regulation SMAD5 FOXO1 24145170 1411717 Positive_regulation SMAD5 FOXO1 25423188 3030102 Positive_regulation SMAD5 ID1 15877825 350618 Positive_regulation SMAD5 NES 24625091 272366 Positive_regulation SMAD5 PIGR 22025622 1651624 Positive_regulation SMAD5 PIGR 22025622 1651625 Positive_regulation SMAD5 PIGR 22025622 1651626 Positive_regulation SMAD5 PIGR 22025622 1651675 Positive_regulation SMAD5 PIGR 22025622 1651702 Positive_regulation SMAD5 PIGR 22025622 1651703 Positive_regulation SMAD5 PIGR 22025622 1651704 Positive_regulation SMAD5 PIGR 22025622 1651728 Positive_regulation SMAD5 PIGR 22025622 1651738 Positive_regulation SMAD5 STK39 21789165 2537753 Positive_regulation SMAD5 STK39 23029472 2697779 Positive_regulation SMAD5 TF 24409331 2907001 Positive_regulation SMAD5 TNF 24743742 573872 Positive_regulation SMAD6 CTGF 21541658 616642 Positive_regulation SMAD6 CTGF 21931601 2553637 Positive_regulation SMAD6 EPHB2 22539964 2622635 Positive_regulation SMAD6 EPHB2 23028582 2691698 Positive_regulation SMAD6 FOXO1 24145170 1411718 Positive_regulation SMAD6 FOXO1 25423188 3030103 Positive_regulation SMAD6 ID1 15877825 350620 Positive_regulation SMAD6 NES 24625091 272367 Positive_regulation SMAD6 PIGR 22025622 1651627 Positive_regulation SMAD6 PIGR 22025622 1651628 Positive_regulation SMAD6 PIGR 22025622 1651629 Positive_regulation SMAD6 PIGR 22025622 1651677 Positive_regulation SMAD6 PIGR 22025622 1651705 Positive_regulation SMAD6 PIGR 22025622 1651706 Positive_regulation SMAD6 PIGR 22025622 1651707 Positive_regulation SMAD6 PIGR 22025622 1651729 Positive_regulation SMAD6 PIGR 22025622 1651739 Positive_regulation SMAD6 STK39 21789165 2537777 Positive_regulation SMAD6 STK39 23029472 2697794 Positive_regulation SMAD6 TF 24409331 2907003 Positive_regulation SMAD6 TNF 24743742 573874 Positive_regulation SMAD7 ANGPT1 24459518 746254 Positive_regulation SMAD7 CTGF 21541658 616644 Positive_regulation SMAD7 CTGF 21931601 2553638 Positive_regulation SMAD7 EPHB2 22539964 2622636 Positive_regulation SMAD7 EPHB2 23028582 2691699 Positive_regulation SMAD7 FOXO1 24145170 1411719 Positive_regulation SMAD7 FOXO1 25423188 3030104 Positive_regulation SMAD7 ID1 15877825 350622 Positive_regulation SMAD7 IL1B 24791137 1916894 Positive_regulation SMAD7 JAG1 24791137 1916876 Positive_regulation SMAD7 NES 24625091 272368 Positive_regulation SMAD7 PIGR 22025622 1651630 Positive_regulation SMAD7 PIGR 22025622 1651631 Positive_regulation SMAD7 PIGR 22025622 1651632 Positive_regulation SMAD7 PIGR 22025622 1651679 Positive_regulation SMAD7 PIGR 22025622 1651708 Positive_regulation SMAD7 PIGR 22025622 1651709 Positive_regulation SMAD7 PIGR 22025622 1651710 Positive_regulation SMAD7 PIGR 22025622 1651730 Positive_regulation SMAD7 PIGR 22025622 1651740 Positive_regulation SMAD7 STK39 21789165 2537801 Positive_regulation SMAD7 STK39 23029472 2697809 Positive_regulation SMAD7 TF 24409331 2907005 Positive_regulation SMAD7 TNF 18781153 431175 Positive_regulation SMAD7 TNF 24743742 573876 Positive_regulation SMAD7 TNF 24791137 1916892 Positive_regulation SMAD9 CTGF 21541658 616646 Positive_regulation SMAD9 CTGF 21931601 2553639 Positive_regulation SMAD9 EPHB2 22539964 2622637 Positive_regulation SMAD9 EPHB2 23028582 2691700 Positive_regulation SMAD9 FOXO1 24145170 1411720 Positive_regulation SMAD9 FOXO1 25423188 3030105 Positive_regulation SMAD9 ID1 15877825 350624 Positive_regulation SMAD9 NES 24625091 272369 Positive_regulation SMAD9 PIGR 22025622 1651633 Positive_regulation SMAD9 PIGR 22025622 1651634 Positive_regulation SMAD9 PIGR 22025622 1651635 Positive_regulation SMAD9 PIGR 22025622 1651681 Positive_regulation SMAD9 PIGR 22025622 1651711 Positive_regulation SMAD9 PIGR 22025622 1651712 Positive_regulation SMAD9 PIGR 22025622 1651713 Positive_regulation SMAD9 PIGR 22025622 1651731 Positive_regulation SMAD9 PIGR 22025622 1651741 Positive_regulation SMAD9 STK39 21789165 2537825 Positive_regulation SMAD9 STK39 23029472 2697824 Positive_regulation SMAD9 TF 24409331 2907007 Positive_regulation SMAD9 TNF 24743742 573878 Positive_regulation SMAP1 TNF 23638396 2236499 Positive_regulation SMAP2 TNF 23638396 2236500 Positive_regulation SMARCA2 FOXO1 25329053 2365565 Positive_regulation SMARCA4 EPHB2 21572418 1925860 Positive_regulation SMARCA4 EPHB2 21860657 813119 Positive_regulation SMARCA4 FOXO1 23604319 1928959 Positive_regulation SMARCB1 CDKN1C 19221586 2405769 Positive_regulation SMARCB1 CDKN1C 19221586 2405773 Positive_regulation SMARCB1 CDKN1C 19221586 2405774 Positive_regulation SMARCC1 EPHB2 21572418 1925861 Positive_regulation SMARCC1 EPHB2 21860657 813120 Positive_regulation SMARCC1 FOXO1 23604319 1928964 Positive_regulation SMARCC2 EPHB2 21572418 1925862 Positive_regulation SMARCC2 EPHB2 21860657 813121 Positive_regulation SMARCD1 PGC 20003344 327250 Positive_regulation SMARCE1 FOXO1 25329053 2365569 Positive_regulation SMC2 TMPRSS4 24934155 1419776 Positive_regulation SMC2 TMPRSS4 24934155 1419814 Positive_regulation SMC2 TNF 21151899 2485268 Positive_regulation SMC2 TNF 3598461 1583546 Positive_regulation SMC3 TNF 21151899 2485272 Positive_regulation SMC3 TNF 3598461 1583550 Positive_regulation SMC4 TMPRSS4 24934155 1419780 Positive_regulation SMC4 TMPRSS4 24934155 1419815 Positive_regulation SMC4 TNF 21151899 2485269 Positive_regulation SMC4 TNF 3598461 1583547 Positive_regulation SMC5 TNF 21151899 2485270 Positive_regulation SMC5 TNF 3598461 1583548 Positive_regulation SMC6 TNF 21151899 2485271 Positive_regulation SMC6 TNF 3598461 1583549 Positive_regulation SMCP TNFSF10 21092273 1860253 Positive_regulation SMG1 FOXO1 18836529 2397341 Positive_regulation SMG1 RNASE1 20817927 2057218 Positive_regulation SMG1 RNASE1 23826386 2812447 Positive_regulation SMG6 RNASE1 25053839 2103141 Positive_regulation SMG8 RNASE1 20817927 2057217 Positive_regulation SMN1 CTGF 22808268 2665298 Positive_regulation SMN1 EPHB2 21103368 2483872 Positive_regulation SMN1 EPHB2 21103368 2483873 Positive_regulation SMN1 EPHB2 23416981 2151751 Positive_regulation SMN1 ID1 23320068 2739469 Positive_regulation SMN1 ID1 23320068 2739508 Positive_regulation SMN1 PECAM1 20682692 715817 Positive_regulation SMN1 SMN2 18791638 2396433 Positive_regulation SMN1 SMN2 21072240 2272871 Positive_regulation SMN1 SMN2 21249120 2493037 Positive_regulation SMN1 SMN2 23285108 2732565 Positive_regulation SMN1 SMN2 23967270 2835477 Positive_regulation SMN1 SMN2 24014320 781959 Positive_regulation SMN1 SMN2 24023935 2844223 Positive_regulation SMN1 SMN2 24023935 2844224 Positive_regulation SMN1 SMN2 25642438 88153 Positive_regulation SMN1 SYNM 22811744 814842 Positive_regulation SMN1 TLR7 21544241 2517356 Positive_regulation SMN1 TNF 19723340 1227339 Positive_regulation SMN1 TNF 19723340 1227341 Positive_regulation SMN2 CAPN1 21209906 2491962 Positive_regulation SMN2 CAPN10 21209906 2491963 Positive_regulation SMN2 CAPN11 21209906 2491964 Positive_regulation SMN2 CAPN12 21209906 2491961 Positive_regulation SMN2 CAPN13 21209906 2491972 Positive_regulation SMN2 CAPN14 21209906 2491973 Positive_regulation SMN2 CAPN15 21209906 2491960 Positive_regulation SMN2 CAPN2 21209906 2491965 Positive_regulation SMN2 CAPN3 21209906 2491966 Positive_regulation SMN2 CAPN5 21209906 2491967 Positive_regulation SMN2 CAPN6 21209906 2491968 Positive_regulation SMN2 CAPN7 21209906 2491969 Positive_regulation SMN2 CAPN8 21209906 2491970 Positive_regulation SMN2 CAPN9 21209906 2491971 Positive_regulation SMN2 CAST 21209906 2492061 Positive_regulation SMN2 CAST 21209906 2492206 Positive_regulation SMN2 COIL 24040563 176575 Positive_regulation SMN2 COP 23284781 2730956 Positive_regulation SMN2 DDX20 17984321 1346082 Positive_regulation SMN2 DDX20 18791638 2396447 Positive_regulation SMN2 DDX20 21072240 2272785 Positive_regulation SMN2 DDX20 21339974 1090523 Positive_regulation SMN2 DDX20 23615451 1814043 Positive_regulation SMN2 DHX9 11149922 1266722 Positive_regulation SMN2 DHX9 11149922 1266756 Positive_regulation SMN2 GEMIN2 17640370 280481 Positive_regulation SMN2 GEMIN2 17984321 1346068 Positive_regulation SMN2 GEMIN2 18791638 2396441 Positive_regulation SMN2 GEMIN2 21339974 1090517 Positive_regulation SMN2 GEMIN2 23615451 1813940 Positive_regulation SMN2 GEMIN2 23615451 1814029 Positive_regulation SMN2 GEMIN2 25122454 2997600 Positive_regulation SMN2 GEMIN4 17984321 1346078 Positive_regulation SMN2 GEMIN4 18791638 2396443 Positive_regulation SMN2 GEMIN4 21072240 2272781 Positive_regulation SMN2 GEMIN4 21339974 1090519 Positive_regulation SMN2 GEMIN4 23615451 1814038 Positive_regulation SMN2 GEMIN5 17984321 1346079 Positive_regulation SMN2 GEMIN5 18791638 2396444 Positive_regulation SMN2 GEMIN5 21072240 2272782 Positive_regulation SMN2 GEMIN5 21339974 1090520 Positive_regulation SMN2 GEMIN5 23221635 2082498 Positive_regulation SMN2 GEMIN5 23615451 1813942 Positive_regulation SMN2 GEMIN5 23615451 1814039 Positive_regulation SMN2 GEMIN6 17984321 1346080 Positive_regulation SMN2 GEMIN6 18791638 2396445 Positive_regulation SMN2 GEMIN6 21072240 2272783 Positive_regulation SMN2 GEMIN6 21339974 1090521 Positive_regulation SMN2 GEMIN6 23615451 1814040 Positive_regulation SMN2 GEMIN7 17984321 1346081 Positive_regulation SMN2 GEMIN7 18791638 2396446 Positive_regulation SMN2 GEMIN7 21072240 2272784 Positive_regulation SMN2 GEMIN7 21339974 1090522 Positive_regulation SMN2 GEMIN7 23615451 1814041 Positive_regulation SMN2 GEMIN8 23615451 1814042 Positive_regulation SMN2 GRAP2 24405637 2221773 Positive_regulation SMN2 HNRNPR 23383159 2748552 Positive_regulation SMN2 IL1A 24237934 1481902 Positive_regulation SMN2 LBH 22047105 2221037 Positive_regulation SMN2 MAPK1 24405637 2221678 Positive_regulation SMN2 MAPK10 24405637 2221679 Positive_regulation SMN2 MAPK11 24405637 2221680 Positive_regulation SMN2 MAPK12 24405637 2221681 Positive_regulation SMN2 MAPK13 24405637 2221682 Positive_regulation SMN2 MAPK14 24405637 2221683 Positive_regulation SMN2 MAPK15 24405637 2221677 Positive_regulation SMN2 MAPK3 24405637 2221684 Positive_regulation SMN2 MAPK4 24405637 2221685 Positive_regulation SMN2 MAPK6 24405637 2221686 Positive_regulation SMN2 MAPK7 24405637 2221687 Positive_regulation SMN2 MAPK8 24405637 2221688 Positive_regulation SMN2 MAPK9 24405637 2221689 Positive_regulation SMN2 MECP2 18971205 1031891 Positive_regulation SMN2 PHF5A 22110043 2069969 Positive_regulation SMN2 PIEZO1 23615451 1813943 Positive_regulation SMN2 PIEZO1 23615451 1813944 Positive_regulation SMN2 PIEZO1 23615451 1813988 Positive_regulation SMN2 PPM1G 17984321 1346020 Positive_regulation SMN2 PPM1G 17984321 1346021 Positive_regulation SMN2 PPM1G 17984321 1346022 Positive_regulation SMN2 PPM1G 17984321 1346246 Positive_regulation SMN2 PPM1G 17984321 1346251 Positive_regulation SMN2 PPM1G 17984321 1346281 Positive_regulation SMN2 PPM1G 17984321 1346288 Positive_regulation SMN2 PRDX2 20020055 2434777 Positive_regulation SMN2 PRKACB 25514431 3034352 Positive_regulation SMN2 PRKACG 25514431 3034353 Positive_regulation SMN2 PRKAR1A 25514431 3034354 Positive_regulation SMN2 PRKAR1B 25514431 3034355 Positive_regulation SMN2 PRKAR2A 25514431 3034356 Positive_regulation SMN2 PRKAR2B 25514431 3034357 Positive_regulation SMN2 ROCK1 22348054 2596667 Positive_regulation SMN2 ROCK2 22348054 2596668 Positive_regulation SMN2 RPL14 23861442 2091272 Positive_regulation SMN2 SF3B5 22110043 2069970 Positive_regulation SMN2 SMN1 21072240 2272780 Positive_regulation SMN2 SMN2 18791638 2396442 Positive_regulation SMN2 SMN2 21339974 1090518 Positive_regulation SMN2 SMN2 23615451 1813941 Positive_regulation SMN2 SMN2 23615451 1814030 Positive_regulation SMN2 SNRPA 17984321 1346069 Positive_regulation SMN2 SNRPA1 22110043 2069967 Positive_regulation SMN2 SNRPB 17984321 1346070 Positive_regulation SMN2 SNRPB 23615451 1814031 Positive_regulation SMN2 SNRPB2 22110043 2069968 Positive_regulation SMN2 SNRPD1 17984321 1346071 Positive_regulation SMN2 SNRPD1 23615451 1814032 Positive_regulation SMN2 SNRPD2 17984321 1346072 Positive_regulation SMN2 SNRPD2 23615451 1814033 Positive_regulation SMN2 SNRPD3 17984321 1346073 Positive_regulation SMN2 SNRPD3 23615451 1814034 Positive_regulation SMN2 SNRPE 17984321 1346074 Positive_regulation SMN2 SNRPE 23615451 1814035 Positive_regulation SMN2 SNRPF 17984321 1346075 Positive_regulation SMN2 SNRPF 23615451 1814036 Positive_regulation SMN2 SNRPG 17984321 1346076 Positive_regulation SMN2 SNRPG 23615451 1814037 Positive_regulation SMN2 SNRPN 17984321 1346077 Positive_regulation SMN2 STRAP 23615451 1814044 Positive_regulation SMN2 TET1 22669976 1203504 Positive_regulation SMN2 TET1 22669976 1203581 Positive_regulation SMN2 TET1 22669976 1203688 Positive_regulation SMN2 TET1 22669976 1203731 Positive_regulation SMN2 TET1 22669976 1203761 Positive_regulation SMN2 TET2 22669976 1203502 Positive_regulation SMN2 TET2 22669976 1203579 Positive_regulation SMN2 TET2 22669976 1203686 Positive_regulation SMN2 TET2 22669976 1203729 Positive_regulation SMN2 TET2 22669976 1203759 Positive_regulation SMN2 TET3 22669976 1203503 Positive_regulation SMN2 TET3 22669976 1203580 Positive_regulation SMN2 TET3 22669976 1203687 Positive_regulation SMN2 TET3 22669976 1203730 Positive_regulation SMN2 TET3 22669976 1203760 Positive_regulation SMN2 TNF 24237934 1481901 Positive_regulation SMN2 WRAP53 25070141 1875955 Positive_regulation SMO STK39 24550888 880096 Positive_regulation SMOX TNF 16008840 3105113 Positive_regulation SMPD1 FAS 10330437 1511767 Positive_regulation SMPD1 FAS 21629700 2525593 Positive_regulation SMPD2 TNF 14979937 100130 Positive_regulation SMPD2 TNF 21904434 163168 Positive_regulation SMPD2 TNF 21904434 163169 Positive_regulation SMPD2 TNF 25180167 3094704 Positive_regulation SMPD2 TNF 25180167 3094705 Positive_regulation SMPD3 TNF 24007266 1667009 Positive_regulation SMPD3 TNF 24007266 1667062 Positive_regulation SMPD3 TNF 24007266 1667128 Positive_regulation SMS TLR7 14699082 1530460 Positive_regulation SMS TLR7 14699082 1530471 Positive_regulation SMS TLR7 24009514 3064118 Positive_regulation SMURF1 TNF 22396737 2608326 Positive_regulation SMURF1 TNF 22396737 2608360 Positive_regulation SMURF1 TNF 22396737 2608365 Positive_regulation SMURF1 TNF 22396737 2608376 Positive_regulation SMURF1 TNF 22396737 2608458 Positive_regulation SMURF1 TNF 23328670 558957 Positive_regulation SMURF1 TNF 23969857 564926 Positive_regulation SMURF1 TNF 24800251 190166 Positive_regulation SMURF2 TNF 22396737 2608327 Positive_regulation SMURF2 TNF 22396737 2608362 Positive_regulation SMURF2 TNF 22396737 2608366 Positive_regulation SMURF2 TNF 22396737 2608377 Positive_regulation SMURF2 TNF 22396737 2608459 Positive_regulation SMYD1 MYH16 24068325 1818887 Positive_regulation SMYD1 MYH3 24068325 1818894 Positive_regulation SNAI1 CTGF 21920318 700017 Positive_regulation SNAI1 EPHB2 19124656 1553503 Positive_regulation SNAI1 EPHB2 19124656 1553504 Positive_regulation SNAI1 EPHB2 19124656 1553537 Positive_regulation SNAI1 EPHB2 21559368 2518917 Positive_regulation SNAI1 EPHB2 22105351 1393656 Positive_regulation SNAI1 EPHB2 24894949 1942396 Positive_regulation SNAI1 HBEGF 22592159 1630915 Positive_regulation SNAI1 TNF 20049734 774451 Positive_regulation SNAI1 VSNL1 22479362 2614935 Positive_regulation SNAI1 VSNL1 22479362 2614953 Positive_regulation SNAI1 VSNL1 22479362 2614955 Positive_regulation SNAI2 EPHB2 14623871 1301310 Positive_regulation SNAI2 EPHB2 14623871 1301471 Positive_regulation SNAI2 EPHB2 14623871 1301481 Positive_regulation SNAI2 EPHB2 21829474 2541148 Positive_regulation SNAI2 ID1 21955753 260973 Positive_regulation SNAI2 JAG1 17984306 1547507 Positive_regulation SNAI2 JAG1 17984306 1547508 Positive_regulation SNAI2 JAG1 17984306 1547509 Positive_regulation SNAI2 JAG1 17984306 1547548 Positive_regulation SNAI2 JAG1 21880181 624022 Positive_regulation SNAI2 MAP2K6 22363839 1687854 Positive_regulation SNAI2 MSX1 21433221 3171199 Positive_regulation SNAI2 NEDD9 21829474 2541160 Positive_regulation SNAI2 NEDD9 21829474 2541162 Positive_regulation SNAI2 PECAM1 18663143 1354140 Positive_regulation SNAI2 TNF 23339680 3226553 Positive_regulation SNAI2 TNF 23339680 3226555 Positive_regulation SNAI2 TNF 23339680 3226556 Positive_regulation SNAPIN SYT8 23469084 2761380 Positive_regulation SNAPIN TNF 24387801 1162639 Positive_regulation SNCA MAMLD1 20624440 2008410 Positive_regulation SNCA SNCAIP 18366718 359885 Positive_regulation SNCAIP GSK3B 21244648 1891871 Positive_regulation SNCAIP HDAC6 23284848 2731065 Positive_regulation SNCAIP PDGFB 7790372 1441295 Positive_regulation SNCAIP REL 10770796 1515136 Positive_regulation SNCAIP SFTPA2 9214378 1461164 Positive_regulation SNCAIP SMC2 7790372 1441290 Positive_regulation SNCAIP SMC3 7790372 1441294 Positive_regulation SNCAIP SMC4 7790372 1441291 Positive_regulation SNCAIP SMC5 7790372 1441292 Positive_regulation SNCAIP SMC6 7790372 1441293 Positive_regulation SNCAIP SYN1 21060871 2481060 Positive_regulation SNCAIP SYN2 21060871 2481061 Positive_regulation SNCAIP SYN3 21060871 2481062 Positive_regulation SNORD87 ANGPT1 21321379 2175397 Positive_regulation SNRPA SMN2 17984321 1346084 Positive_regulation SNRPA SMN2 18791638 2396449 Positive_regulation SNRPA SMN2 20019802 2312085 Positive_regulation SNRPA SMN2 21339974 1090525 Positive_regulation SNRPA SMN2 21490958 2324005 Positive_regulation SNRPA SMN2 23615451 1813946 Positive_regulation SNRPA SMN2 23615451 1814046 Positive_regulation SNRPA SMN2 23631896 1881393 Positive_regulation SNRPA1 SMN2 22110043 2069976 Positive_regulation SNRPB SMN2 17984321 1346100 Positive_regulation SNRPB SMN2 18791638 2396456 Positive_regulation SNRPB SMN2 20019802 2312090 Positive_regulation SNRPB SMN2 21339974 1090532 Positive_regulation SNRPB SMN2 21490958 2324012 Positive_regulation SNRPB SMN2 23615451 1813950 Positive_regulation SNRPB SMN2 23615451 1814062 Positive_regulation SNRPB SMN2 23631896 1881403 Positive_regulation SNRPB TNF 24237934 1481903 Positive_regulation SNRPB2 SMN2 22110043 2069990 Positive_regulation SNRPD1 SMN2 17984321 1346116 Positive_regulation SNRPD1 SMN2 20019802 2312095 Positive_regulation SNRPD1 SMN2 21490958 2324019 Positive_regulation SNRPD1 SMN2 23631896 1881413 Positive_regulation SNRPD1 TNF 24237934 1481905 Positive_regulation SNRPD2 SMN2 17984321 1346121 Positive_regulation SNRPD2 SMN2 20019802 2312100 Positive_regulation SNRPD2 SMN2 21490958 2324026 Positive_regulation SNRPD2 SMN2 23631896 1881423 Positive_regulation SNRPD2 TNF 24237934 1481907 Positive_regulation SNRPD3 SMN2 17984321 1346126 Positive_regulation SNRPD3 SMN2 20019802 2312105 Positive_regulation SNRPD3 SMN2 21490958 2324033 Positive_regulation SNRPD3 SMN2 23631896 1881433 Positive_regulation SNRPD3 TNF 24237934 1481909 Positive_regulation SNRPE CCND1 24848372 2972402 Positive_regulation SNRPE CCND1 24848372 2972418 Positive_regulation SNRPE SMN2 17984321 1346131 Positive_regulation SNRPE SMN2 20019802 2312110 Positive_regulation SNRPE SMN2 21490958 2324040 Positive_regulation SNRPE SMN2 23631896 1881443 Positive_regulation SNRPE TNF 24237934 1481911 Positive_regulation SNRPF SMN2 17984321 1346136 Positive_regulation SNRPF SMN2 20019802 2312115 Positive_regulation SNRPF SMN2 21490958 2324047 Positive_regulation SNRPF SMN2 23631896 1881453 Positive_regulation SNRPF TNF 24237934 1481913 Positive_regulation SNRPG SMN2 17984321 1346141 Positive_regulation SNRPG SMN2 20019802 2312120 Positive_regulation SNRPG SMN2 21490958 2324054 Positive_regulation SNRPG SMN2 23631896 1881463 Positive_regulation SNRPG TNF 24237934 1481915 Positive_regulation SNRPN SMN2 17984321 1346146 Positive_regulation SNRPN SMN2 20019802 2312125 Positive_regulation SNRPN SMN2 21490958 2324061 Positive_regulation SNRPN SMN2 23631896 1881473 Positive_regulation SOAT1 CCND1 22276155 2590202 Positive_regulation SOAT1 EPHB2 20030801 526428 Positive_regulation SOAT1 GPR115 24662938 503131 Positive_regulation SOAT1 GPR132 24662938 503120 Positive_regulation SOAT1 GPR87 24662938 503200 Positive_regulation SOAT1 JAG1 24968269 1127928 Positive_regulation SOAT1 KRT38 7500028 1587285 Positive_regulation SOAT1 TNF 22115362 212641 Positive_regulation SOAT1 TNF 24660115 3126262 Positive_regulation SOAT1 TNF 25400510 1628044 Positive_regulation SOCS1 ITGAL 22911848 2677083 Positive_regulation SOCS1 S100A7 15217486 458453 Positive_regulation SOCS1 S100A7 15217497 458470 Positive_regulation SOCS1 S100A7 20955608 585857 Positive_regulation SOCS1 TLR7 20862390 979480 Positive_regulation SOCS1 TLR7 20862390 979530 Positive_regulation SOCS1 TLR7 20862390 979575 Positive_regulation SOCS1 TLR7 20862390 979623 Positive_regulation SOCS1 TLR7 22566885 899572 Positive_regulation SOCS1 TLR7 23505488 2766255 Positive_regulation SOCS1 TNF 11208867 1518800 Positive_regulation SOCS1 TNF 22203897 1686944 Positive_regulation SOCS1 TNF 22739986 556335 Positive_regulation SOCS1 TNF 22739986 556336 Positive_regulation SOCS1 TNFSF10 20185810 712894 Positive_regulation SOCS1 TNFSF10 20185810 712896 Positive_regulation SOCS2 ARSA 18411340 1550481 Positive_regulation SOCS2 TLR7 22291912 2591122 Positive_regulation SOCS2 TLR7 22291912 2591123 Positive_regulation SOCS2 TLR7 22291912 2591151 Positive_regulation SOCS2 TLR7 22291912 2591166 Positive_regulation SOCS2 TLR7 22291912 2591191 Positive_regulation SOCS2 TLR7 24489947 2917104 Positive_regulation SOCS3 EPHB2 21286383 1037836 Positive_regulation SOCS3 EPHB2 23782265 151674 Positive_regulation SOCS3 EPHB2 23782265 151675 Positive_regulation SOCS3 EPHB2 23782265 151697 Positive_regulation SOCS3 EPHB2 23782265 151723 Positive_regulation SOCS3 EPHB2 23782265 151736 Positive_regulation SOCS3 EPHB2 23782265 151739 Positive_regulation SOCS3 IL1B 18989459 3042187 Positive_regulation SOCS3 MAP2K6 18989459 3042185 Positive_regulation SOCS3 TLR7 22566885 899582 Positive_regulation SOCS3 TNF 21242294 1562403 Positive_regulation SOCS3 TNF 22203897 1686946 Positive_regulation SOCS3 TNF 22500980 355789 Positive_regulation SOCS3 TNF 22500980 355795 Positive_regulation SOCS3 TNF 22739986 556337 Positive_regulation SOCS3 TNF 22739986 556338 Positive_regulation SOCS3 TNF 23170143 1024275 Positive_regulation SOCS3 TNF 23533689 2225619 Positive_regulation SOCS3 TNF 23565388 1044372 Positive_regulation SOCS3 TNF 23772224 878746 Positive_regulation SOCS3 TNF 24101903 962424 Positive_regulation SOCS3 TNF 24244348 2879483 Positive_regulation SOCS3 TNF 24966659 1917100 Positive_regulation SOCS3 TNF 25352752 1917440 Positive_regulation SOCS3 TNF 25352752 1917488 Positive_regulation SOD1 FOXO1 15492127 1533774 Positive_regulation SOD1 FOXO1 19801995 8158 Positive_regulation SOD1 FOXO1 21212461 28907 Positive_regulation SOD1 FOXO1 23299244 1488918 Positive_regulation SOD1 GPNMB 22891158 3131104 Positive_regulation SOD1 IL1B 11286475 418511 Positive_regulation SOD1 IL1B 15512788 831002 Positive_regulation SOD1 IL1B 22683550 30685 Positive_regulation SOD1 ITGB2 25423296 3030118 Positive_regulation SOD1 ITGB2 25423296 3030121 Positive_regulation SOD1 ITGB2 25423296 3030124 Positive_regulation SOD1 OSR1 25206429 2004396 Positive_regulation SOD1 PGC 22563483 2626871 Positive_regulation SOD1 PGC 25162824 1129234 Positive_regulation SOD1 SYNM 19695098 626849 Positive_regulation SOD1 TNF 10359573 1511784 Positive_regulation SOD1 TNF 18472951 1743317 Positive_regulation SOD1 TNF 18472951 1743320 Positive_regulation SOD1 TNF 1979590 1556412 Positive_regulation SOD1 TNF 21403844 506727 Positive_regulation SOD1 TNF 21966220 3209151 Positive_regulation SOD1 TNF 7523104 796018 Positive_regulation SOD1 TNF 7705313 796496 Positive_regulation SOD1 TNF 8027185 1444182 Positive_regulation SOD1 ZFP57 20460361 1499251 Positive_regulation SOD2 FOXO1 15492127 1533780 Positive_regulation SOD2 FOXO1 15492127 1533781 Positive_regulation SOD2 FOXO1 19801995 8162 Positive_regulation SOD2 FOXO1 20668652 2457220 Positive_regulation SOD2 FOXO1 20668652 2457239 Positive_regulation SOD2 FOXO1 20844313 27659 Positive_regulation SOD2 FOXO1 21212461 28911 Positive_regulation SOD2 FOXO1 22820707 30774 Positive_regulation SOD2 FOXO1 23299244 1488922 Positive_regulation SOD2 FOXO1 23801966 961510 Positive_regulation SOD2 FOXO1 24556689 572282 Positive_regulation SOD2 IL1B 11286475 418512 Positive_regulation SOD2 IL1B 15512788 831003 Positive_regulation SOD2 LBP 25045414 2229607 Positive_regulation SOD2 LBP 25045414 2229615 Positive_regulation SOD2 OSR1 25206429 2004398 Positive_regulation SOD2 PGC 20383327 2445881 Positive_regulation SOD2 PGC 22563483 2626872 Positive_regulation SOD2 PGC 25162824 1129235 Positive_regulation SOD2 PGC 25375380 579014 Positive_regulation SOD2 SYNM 19695098 626850 Positive_regulation SOD2 TNF 10359573 1511786 Positive_regulation SOD2 TNF 17324256 320020 Positive_regulation SOD2 TNF 18472951 1743318 Positive_regulation SOD2 TNF 18472951 1743321 Positive_regulation SOD2 TNF 18588690 361740 Positive_regulation SOD2 TNF 18588690 361741 Positive_regulation SOD2 TNF 18588690 361776 Positive_regulation SOD2 TNF 18588690 361777 Positive_regulation SOD2 TNF 1979590 1556413 Positive_regulation SOD2 TNF 21403844 506728 Positive_regulation SOD2 TNF 21966220 3209152 Positive_regulation SOD2 TNF 22322095 1882568 Positive_regulation SOD2 TNF 22322095 1882569 Positive_regulation SOD2 TNF 22322095 1882583 Positive_regulation SOD2 TNF 22471522 150141 Positive_regulation SOD2 TNF 7523104 796019 Positive_regulation SOD2 TNF 7705313 796497 Positive_regulation SOD2 TNF 8027185 1444183 Positive_regulation SOD2 ZFP57 20460361 1499269 Positive_regulation SOD3 FOXO1 15492127 1533787 Positive_regulation SOD3 FOXO1 19801995 8166 Positive_regulation SOD3 FOXO1 21212461 28915 Positive_regulation SOD3 FOXO1 23299244 1488926 Positive_regulation SOD3 IL1B 11286475 418513 Positive_regulation SOD3 IL1B 15512788 831004 Positive_regulation SOD3 OSR1 25206429 2004400 Positive_regulation SOD3 PGC 22563483 2626873 Positive_regulation SOD3 PGC 25162824 1129236 Positive_regulation SOD3 SYNM 19695098 626851 Positive_regulation SOD3 TNF 10359573 1511788 Positive_regulation SOD3 TNF 18461174 2388474 Positive_regulation SOD3 TNF 18472951 1743319 Positive_regulation SOD3 TNF 18472951 1743322 Positive_regulation SOD3 TNF 1979590 1556414 Positive_regulation SOD3 TNF 21403844 506729 Positive_regulation SOD3 TNF 21966220 3209153 Positive_regulation SOD3 TNF 25025040 194670 Positive_regulation SOD3 TNF 7523104 796020 Positive_regulation SOD3 TNF 7705313 796498 Positive_regulation SOD3 TNF 8027185 1444184 Positive_regulation SOD3 ZFP57 20460361 1499287 Positive_regulation SORBS3 EPHB2 19753101 2267979 Positive_regulation SORL1 BDNF 22870188 2671962 Positive_regulation SORL1 BDNF 23977241 2839401 Positive_regulation SORL1 BDNF 23977241 2839402 Positive_regulation SORL1 GGA1 22621900 1803308 Positive_regulation SORL1 GGA1 22621900 1803317 Positive_regulation SORL1 GGA1 22621900 1803322 Positive_regulation SORL1 LRPAP1 18776935 2396256 Positive_regulation SORL1 LRPAP1 18776935 2396297 Positive_regulation SORT1 TNF 21863317 1644766 Positive_regulation SOS1 EPHB2 18755034 401559 Positive_regulation SOS1 EPHB2 22761938 2659355 Positive_regulation SOS1 EPHB2 23027900 1400293 Positive_regulation SOS1 EPHB2 24027568 908782 Positive_regulation SOS1 EPHB2 24957684 2232031 Positive_regulation SOS1 EPHB2 24957684 2232045 Positive_regulation SOS1 JAG1 23613664 2345425 Positive_regulation SOS1 JAG1 23613664 2345439 Positive_regulation SOS1 JAG1 24319148 2096485 Positive_regulation SOS1 JAG1 24319148 2096519 Positive_regulation SOS2 EPHB2 18755034 401560 Positive_regulation SOS2 EPHB2 23027900 1400294 Positive_regulation SOS2 EPHB2 24027568 908783 Positive_regulation SOS2 EPHB2 24957684 2232032 Positive_regulation SOS2 EPHB2 24957684 2232046 Positive_regulation SOS2 JAG1 23613664 2345426 Positive_regulation SOS2 JAG1 23613664 2345442 Positive_regulation SOS2 JAG1 24319148 2096490 Positive_regulation SOS2 JAG1 24319148 2096528 Positive_regulation SOST PTGER2 21723865 850887 Positive_regulation SOST TNF 22477520 694251 Positive_regulation SOST TNF 23762093 637748 Positive_regulation SOST TNF 24286133 130366 Positive_regulation SOX10 NGFR 24799129 2960767 Positive_regulation SOX11 CCND1 21738649 2533137 Positive_regulation SOX17 CCND1 19479035 2417339 Positive_regulation SOX17 CCND1 19479035 2417456 Positive_regulation SOX18 EPHB2 23549166 543149 Positive_regulation SOX18 EPHB2 23549166 543150 Positive_regulation SOX2 AGR2 20011520 2433310 Positive_regulation SOX2 EPHB2 24643025 2935526 Positive_regulation SOX2 EPHB2 24643025 2935544 Positive_regulation SOX2 FOXO1 25369332 3022703 Positive_regulation SOX2 ID1 24457967 571670 Positive_regulation SOX2 IFI27 23217425 615790 Positive_regulation SOX2 JAG1 23071561 2702857 Positive_regulation SOX2 JAG1 24465223 2355658 Positive_regulation SOX2 MAP2K6 25340657 2366629 Positive_regulation SOX2 MSX1 24550838 964109 Positive_regulation SOX2 ZFP57 24550733 2356703 Positive_regulation SOX9 CREB3L2 24711445 1209098 Positive_regulation SOX9 CREB3L2 24711445 1209126 Positive_regulation SOX9 EPHB2 19753101 2267963 Positive_regulation SOX9 EPHB2 20800688 2222091 Positive_regulation SOX9 EPHB2 22761195 2180430 Positive_regulation SOX9 EPHB2 23840193 878933 Positive_regulation SOX9 FZD4 25277175 2202872 Positive_regulation SOX9 MAP2K6 17895999 2378829 Positive_regulation SOX9 MAP2K6 23840193 878939 Positive_regulation SOX9 S100B 25536222 3035726 Positive_regulation SOX9 TNF 18182117 109757 Positive_regulation SOX9 TNF 18182117 109787 Positive_regulation SOX9 TNF 18182117 109791 Positive_regulation SOX9 TNF 18182117 109792 Positive_regulation SOX9 TNF 18182117 109798 Positive_regulation SP1 EPHB2 17916230 3108416 Positive_regulation SP1 EPHB2 18852899 2397565 Positive_regulation SP1 EPHB2 18852899 2397566 Positive_regulation SP1 EPHB2 18852899 2397589 Positive_regulation SP1 EPHB2 18852899 2397590 Positive_regulation SP1 EPHB2 18852899 2397630 Positive_regulation SP1 EPHB2 21829524 2541573 Positive_regulation SP1 EPHB2 21829524 2541587 Positive_regulation SP1 EPHB2 23696862 2795575 Positive_regulation SP1 EPHB2 23696862 2795590 Positive_regulation SP1 EPHB2 24669294 847609 Positive_regulation SP1 EPHB2 24788806 2959443 Positive_regulation SP1 EPHB2 24788806 2959444 Positive_regulation SP1 EPHB2 25499743 476671 Positive_regulation SP1 FOXO1 21765927 2536273 Positive_regulation SP1 MUC16 17391532 3108027 Positive_regulation SP1 PADI3 18923650 2397764 Positive_regulation SP1 TMPRSS4 24748857 1021865 Positive_regulation SP1 TNF 22534375 125569 Positive_regulation SP1 TNF 24141333 88928 Positive_regulation SP3 PADI3 18923650 2397765 Positive_regulation SP3 TMPRSS4 24748857 1021866 Positive_regulation SP4 CAPN8 19450264 1655770 Positive_regulation SPAG11B EPHB2 22159280 83877 Positive_regulation SPAG11B PTGER2 PMC3255002 395599 Positive_regulation SPAG8 TNF 22294469 135312 Positive_regulation SPAG8 TNF 24367624 2900378 Positive_regulation SPAG8 TNF 25608777 134109 Positive_regulation SPARC CTGF 23390502 2750817 Positive_regulation SPARC MMP28 23470450 2117234 Positive_regulation SPARC MMP28 24551460 2003406 Positive_regulation SPARC MMP28 25147739 413695 Positive_regulation SPARC MMP28 25147739 413747 Positive_regulation SPARC MMP7 23470450 2117249 Positive_regulation SPARC MMP7 24551460 2003421 Positive_regulation SPARC MMP7 25147739 413710 Positive_regulation SPARC MMP7 25147739 413762 Positive_regulation SPC24 FHL1 22496762 2617367 Positive_regulation SPESP1 IL1B 24330735 3210792 Positive_regulation SPHK1 ABL1 24970218 209064 Positive_regulation SPHK1 AKT1 19956567 2432070 Positive_regulation SPHK1 AKT2 19956567 2432071 Positive_regulation SPHK1 AKT3 19956567 2432072 Positive_regulation SPHK1 APOB 23817990 1886205 Positive_regulation SPHK1 BCR 24917786 932047 Positive_regulation SPHK1 BCR 24970218 209063 Positive_regulation SPHK1 CA2 16203868 1538012 Positive_regulation SPHK1 CALM3 16203868 1538013 Positive_regulation SPHK1 CALML3 PMC4273882 661378 Positive_regulation SPHK1 CD14 23817990 1886204 Positive_regulation SPHK1 CEBPB 24597747 1701383 Positive_regulation SPHK1 EDN1 23818902 2119918 Positive_regulation SPHK1 EGF 21668976 305690 Positive_regulation SPHK1 EGF 24970174 208682 Positive_regulation SPHK1 EGF 25309325 871467 Positive_regulation SPHK1 EGFR 16636149 1329281 Positive_regulation SPHK1 EGFR 16636149 1329297 Positive_regulation SPHK1 EGFR 16636149 1329298 Positive_regulation SPHK1 EGFR 16636149 1329347 Positive_regulation SPHK1 EGFR 24970174 208681 Positive_regulation SPHK1 EGFR 25245676 2201806 Positive_regulation SPHK1 EGFR 25309325 871468 Positive_regulation SPHK1 EPHB2 20634980 2455737 Positive_regulation SPHK1 EPHB2 24970177 208792 Positive_regulation SPHK1 ESR1 21673993 2528352 Positive_regulation SPHK1 ESR1 24970218 209065 Positive_regulation SPHK1 GAB2 22654878 901163 Positive_regulation SPHK1 GPER1 16636149 1329252 Positive_regulation SPHK1 IGF1 22788716 3161131 Positive_regulation SPHK1 IGFBP3 25374561 881333 Positive_regulation SPHK1 IL1A 21489260 362944 Positive_regulation SPHK1 IL1A 24464131 1959664 Positive_regulation SPHK1 IL1A 24464131 1959689 Positive_regulation SPHK1 IL1A 24464131 1959753 Positive_regulation SPHK1 INS 24349009 2896531 Positive_regulation SPHK1 INS 24349009 2896535 Positive_regulation SPHK1 INS 24349009 2896536 Positive_regulation SPHK1 INS 24349009 2896540 Positive_regulation SPHK1 INS 24349009 2896551 Positive_regulation SPHK1 KDR 25417698 1947381 Positive_regulation SPHK1 KDR 25417698 1947382 Positive_regulation SPHK1 KDR 25417698 1947395 Positive_regulation SPHK1 KRAS 24970218 209066 Positive_regulation SPHK1 LPA 21936950 1697761 Positive_regulation SPHK1 LPA 23817990 1886206 Positive_regulation SPHK1 MAP2K1 20634980 2455797 Positive_regulation SPHK1 MAP2K2 20634980 2455798 Positive_regulation SPHK1 MAP2K3 20634980 2455799 Positive_regulation SPHK1 MAP2K4 20634980 2455800 Positive_regulation SPHK1 MAP2K5 20634980 2455801 Positive_regulation SPHK1 MAP2K6 20634980 2455802 Positive_regulation SPHK1 MAP2K7 20634980 2455803 Positive_regulation SPHK1 MAPK1 20634980 2455738 Positive_regulation SPHK1 MAPK1 22788716 3161132 Positive_regulation SPHK1 MAPK1 25245676 2201807 Positive_regulation SPHK1 MAPK3 16636149 1329348 Positive_regulation SPHK1 MAPK3 20634980 2455739 Positive_regulation SPHK1 MAPK3 22788716 3161133 Positive_regulation SPHK1 MAPK3 23922976 2827850 Positive_regulation SPHK1 MAPK3 24970177 208700 Positive_regulation SPHK1 MAPK3 25153718 2198621 Positive_regulation SPHK1 MAPK3 25245676 2201808 Positive_regulation SPHK1 MBTPS1 20577214 1985428 Positive_regulation SPHK1 MBTPS1 21887342 2549373 Positive_regulation SPHK1 MBTPS1 24005861 1110920 Positive_regulation SPHK1 MBTPS1 24069553 1706829 Positive_regulation SPHK1 MBTPS1 24586752 2926278 Positive_regulation SPHK1 NGF 25356505 1133633 Positive_regulation SPHK1 NPC1 25417698 1947356 Positive_regulation SPHK1 NR0B1 24069553 1706825 Positive_regulation SPHK1 PIK3CA 19956567 2432073 Positive_regulation SPHK1 PIK3CA 20634980 2455673 Positive_regulation SPHK1 PIK3CA 20634980 2455718 Positive_regulation SPHK1 PIK3CA 22654878 901164 Positive_regulation SPHK1 PIK3R1 19956567 2432074 Positive_regulation SPHK1 PIK3R1 20634980 2455674 Positive_regulation SPHK1 PIK3R1 20634980 2455719 Positive_regulation SPHK1 PIK3R1 22654878 901165 Positive_regulation SPHK1 PLD1 22136116 244765 Positive_regulation SPHK1 PLD2 22136116 244766 Positive_regulation SPHK1 PLD3 22136116 244761 Positive_regulation SPHK1 PLD4 22136116 244762 Positive_regulation SPHK1 PLD5 22136116 244763 Positive_regulation SPHK1 PLD6 22136116 244764 Positive_regulation SPHK1 PTGS2 23818902 2119920 Positive_regulation SPHK1 PTGS2 24385109 1880233 Positive_regulation SPHK1 S1PR1 20852647 1954420 Positive_regulation SPHK1 S1PR1 24025642 1709536 Positive_regulation SPHK1 S1PR1 24349009 2896544 Positive_regulation SPHK1 S1PR1 25010828 2988052 Positive_regulation SPHK1 S1PR1 25356505 1133632 Positive_regulation SPHK1 S1PR2 25010828 2988054 Positive_regulation SPHK1 S1PR3 16636149 1329280 Positive_regulation SPHK1 S1PR3 25010828 2988053 Positive_regulation SPHK1 S1PR4 25010828 2988055 Positive_regulation SPHK1 S1PR5 25010828 2988051 Positive_regulation SPHK1 SMAD1 21798099 3160425 Positive_regulation SPHK1 SMAD2 21798099 3160426 Positive_regulation SPHK1 SMAD3 21798099 3160427 Positive_regulation SPHK1 SMAD4 21798099 3160428 Positive_regulation SPHK1 SMAD5 21798099 3160429 Positive_regulation SPHK1 SMAD6 21798099 3160430 Positive_regulation SPHK1 SMAD7 21798099 3160431 Positive_regulation SPHK1 SMAD9 21798099 3160432 Positive_regulation SPHK1 SPHK2 16636149 1329296 Positive_regulation SPHK1 SPHK2 16636149 1329364 Positive_regulation SPHK1 SPHK2 21904650 2223767 Positive_regulation SPHK1 SPHK2 25061328 645449 Positive_regulation SPHK1 SPNS2 25330231 3017379 Positive_regulation SPHK1 SPP1 10545499 1251516 Positive_regulation SPHK1 SPP2 10545499 1251517 Positive_regulation SPHK1 TGFB1 21668976 305685 Positive_regulation SPHK1 TGFB2 21668976 305686 Positive_regulation SPHK1 TGFB3 21668976 305687 Positive_regulation SPHK1 TLR2 20634980 2455792 Positive_regulation SPHK1 TNF 20577214 1985427 Positive_regulation SPHK1 TNF 20577214 1985432 Positive_regulation SPHK1 TNF 21668976 305688 Positive_regulation SPHK1 TNF 21936950 1697754 Positive_regulation SPHK1 TP53 23028939 2693651 Positive_regulation SPHK1 TRAF2 22470350 956732 Positive_regulation SPHK1 VEGFA 21668976 305689 Positive_regulation SPHK1 VEGFA 21876704 3172850 Positive_regulation SPHK1 VEGFA 24970169 208646 Positive_regulation SPHK1 VEGFA 24970177 208779 Positive_regulation SPHK1 VEGFA 25417698 1947354 Positive_regulation SPHK1 VEGFA 25417698 1947355 Positive_regulation SPHK1 VEGFA 25417698 1947373 Positive_regulation SPHK1 VEGFA 25417698 1947377 Positive_regulation SPHK1 VEGFA 25417698 1947378 Positive_regulation SPHK1 VEGFA 25417698 1947386 Positive_regulation SPHK2 SPHK1 16636149 1329365 Positive_regulation SPHK2 SPHK1 21904650 2223768 Positive_regulation SPI1 CD14 22879381 2080317 Positive_regulation SPP1 ALOX5 22355367 2597400 Positive_regulation SPP1 CYP24A1 19015318 1361176 Positive_regulation SPP1 EPHB2 15084239 458360 Positive_regulation SPP1 EPHB2 15084239 458374 Positive_regulation SPP1 EPHB2 21406114 286456 Positive_regulation SPP1 EPHB2 21406114 286457 Positive_regulation SPP1 EPHB2 21406114 286564 Positive_regulation SPP1 EPHB2 24944898 1888024 Positive_regulation SPP1 MMP28 24944898 1887919 Positive_regulation SPP1 MMP7 16128620 2368473 Positive_regulation SPP1 MMP7 24944898 1887934 Positive_regulation SPP1 PLAU 20868520 1859498 Positive_regulation SPP1 SPHK1 10545499 1251518 Positive_regulation SPP1 SPHK1 10545499 1251519 Positive_regulation SPP1 SPHK1 10545499 1251559 Positive_regulation SPP1 TGM2 24265865 206077 Positive_regulation SPP1 TLR7 23508732 906336 Positive_regulation SPP1 TNF 19765294 326373 Positive_regulation SPP1 TNF 21345222 121565 Positive_regulation SPP1 TNF 24490170 186720 Positive_regulation SPP1 TNF 24490170 186721 Positive_regulation SPP2 SPHK1 10545499 1251522 Positive_regulation SPP2 SPHK1 10545499 1251523 Positive_regulation SPP2 SPHK1 10545499 1251561 Positive_regulation SPR MIP 22783161 937426 Positive_regulation SPR MIP 25333796 2288259 Positive_regulation SPRED1 EPHB2 25324472 32293 Positive_regulation SPRED1 MAP2K6 24970815 2194283 Positive_regulation SPRED2 MAP2K6 24970815 2194276 Positive_regulation SPRR1B SDCBP 25593999 2173504 Positive_regulation SPRR1B SDCBP 25593999 2173508 Positive_regulation SPRR1B SDCBP 25593999 2173509 Positive_regulation SPRR1B SDCBP 25593999 2173514 Positive_regulation SPRR1B SDCBP 25593999 2173515 Positive_regulation SPRR3 GABPA 22383093 778353 Positive_regulation SPRR3 GABPA 22383093 778354 Positive_regulation SPRR3 IL13 23844115 2819412 Positive_regulation SPRR3 IL4 23844115 2819413 Positive_regulation SPRR3 JUN 24796531 2960562 Positive_regulation SPRR3 JUN 24796531 2960564 Positive_regulation SPRR3 JUN 24796531 2960569 Positive_regulation SPRR3 STAT3 23844115 2819455 Positive_regulation SPRR3 STAT6 23844115 2819411 Positive_regulation SPRY1 EPHB2 24250280 2299037 Positive_regulation SPRY1 EPHB2 24642617 442721 Positive_regulation SPRY2 EPHB2 22666537 3130605 Positive_regulation SPRY2 EPHB2 24250280 2299038 Positive_regulation SPRY3 EPHB2 24250280 2299039 Positive_regulation SPRY4 EPHB2 24250280 2299041 Positive_regulation SPRY4 MAP2K6 24970815 2194269 Positive_regulation SPRY4 WNT7A 24744103 494519 Positive_regulation SPRY4 WNT7A 24744103 494653 Positive_regulation SQSTM1 CAPN8 24553345 984530 Positive_regulation SQSTM1 CAPN8 24553345 984531 Positive_regulation SRC ADRB2 20670417 403094 Positive_regulation SRC ADRB2 23360994 1934878 Positive_regulation SRC ADRB2 23360994 1934887 Positive_regulation SRC ADRB2 23360994 1934906 Positive_regulation SRC ANGPT1 24642125 614207 Positive_regulation SRC CAPN8 23551528 1480291 Positive_regulation SRC CCND1 23098208 472602 Positive_regulation SRC CEACAM6 25398131 3027579 Positive_regulation SRC CEACAM6 25398131 3027595 Positive_regulation SRC CTGF 19152120 1478437 Positive_regulation SRC CTGF 21760921 2535977 Positive_regulation SRC CTGF 21760921 2535999 Positive_regulation SRC CTGF 21760921 2536007 Positive_regulation SRC CTGF 23175185 548179 Positive_regulation SRC EPHB2 17897439 461232 Positive_regulation SRC EPHB2 19254952 1165627 Positive_regulation SRC EPHB2 19602257 385600 Positive_regulation SRC EPHB2 19752167 811480 Positive_regulation SRC EPHB2 21401944 304777 Positive_regulation SRC EPHB2 23942551 728388 Positive_regulation SRC EPHB2 25356505 1132664 Positive_regulation SRC F2R 24215724 538190 Positive_regulation SRC F2R 24385683 1756400 Positive_regulation SRC GLP1R 21716694 831720 Positive_regulation SRC HBEGF 23213380 167782 Positive_regulation SRC MAP2K6 12876277 1294739 Positive_regulation SRC MAP2K6 18573916 1353077 Positive_regulation SRC MAP2K6 21049052 2480610 Positive_regulation SRC MAP2K6 21401944 304783 Positive_regulation SRC MAP2K6 21411864 2175664 Positive_regulation SRC MAP2K6 25254972 3069489 Positive_regulation SRC MMP28 23213380 167812 Positive_regulation SRC MMP28 25356505 1133649 Positive_regulation SRC MMP7 23213380 167827 Positive_regulation SRC MMP7 25356505 1133665 Positive_regulation SRC NEDD9 24058594 2848158 Positive_regulation SRC PECAM1 18710921 1354887 Positive_regulation SRC PECAM1 23169049 1934657 Positive_regulation SRC PLAT 24904407 859156 Positive_regulation SRC PLAU 20868520 1859501 Positive_regulation SRC PTGER2 PMC3255002 395598 Positive_regulation SRC TLR7 25197169 1762058 Positive_regulation SRC TNF 10637272 1514173 Positive_regulation SRC TNF 23690670 1752090 Positive_regulation SRC TNF 24502696 1233212 Positive_regulation SRC TNF 24502696 1233316 Positive_regulation SRC TNF 24502696 1233350 Positive_regulation SRC TNFSF10 20419107 2447020 Positive_regulation SRC TNFSF10 24745479 474852 Positive_regulation SRC TNFSF10 24745479 474877 Positive_regulation SREBF1 FAS 20041157 2435606 Positive_regulation SREBF1 FAS 22370853 1140327 Positive_regulation SREBF1 LBP 25013763 194524 Positive_regulation SREBF1 PCSK9 19687008 1166610 Positive_regulation SREBF1 TNF 21988829 1723922 Positive_regulation SREBF1 TNF 25045276 645404 Positive_regulation SREBF1 TNF 25479248 2119154 Positive_regulation SREBF2 FAS 24843688 1494555 Positive_regulation SRF EPHB2 20446923 651371 Positive_regulation SRF EPHB2 21479245 2511461 Positive_regulation SRF EPHB2 24386331 2903522 Positive_regulation SRF STK39 23840342 2812629 Positive_regulation SRF TNF 24386331 2903595 Positive_regulation SRF TNF 24386331 2903655 Positive_regulation SRGN CALR 23162553 905066 Positive_regulation SRGN CD79A 19958557 365718 Positive_regulation SRGN ELL 20032306 1772620 Positive_regulation SRGN INS 23846835 731866 Positive_regulation SRGN INS 23860823 731867 Positive_regulation SRGN INS 23860823 731868 Positive_regulation SRGN MYL2 18086913 1346864 Positive_regulation SRGN TCEA1 20032306 1772619 Positive_regulation SRGN ZGLP1 21885869 719771 Positive_regulation SRP14 SMN2 23221635 2082674 Positive_regulation SRP19 SMN2 23221635 2082679 Positive_regulation SRP54 SMN2 23221635 2082684 Positive_regulation SRP68 SMN2 23221635 2082689 Positive_regulation SRP72 SMN2 23221635 2082694 Positive_regulation SRP9 SMN2 23221635 2082699 Positive_regulation SRSF1 TNF 24940033 1917089 Positive_regulation SSNA1 NES 15251038 277758 Positive_regulation SST EPHB2 21589940 2523402 Positive_regulation SST GLP1R 23818527 727640 Positive_regulation ST13 PDZK1 21653824 1791344 Positive_regulation ST13 PDZK1 21653824 1791358 Positive_regulation ST14 PLAU 18219094 736109 Positive_regulation ST3 GNE 20383336 2445906 Positive_regulation ST3GAL4 PODXL 23560927 294332 Positive_regulation ST3GAL4 TNF 25501750 3033674 Positive_regulation ST8SIA1 TNF 23626833 2784972 Positive_regulation ST8SIA2 TNF 21206910 2491211 Positive_regulation STAB2 EPHB2 24586357 2924391 Positive_regulation STAR EPHB2 22479211 2334478 Positive_regulation STAR EPHB2 24945345 2981089 Positive_regulation STAR EPHB2 24945345 2981097 Positive_regulation STAR EPHB2 24945345 2981099 Positive_regulation STAR EPHB2 24945345 2981115 Positive_regulation STAT1 CLU 18631387 1503196 Positive_regulation STAT1 EDN2 22128240 1913116 Positive_regulation STAT1 EPHB2 21526200 2514080 Positive_regulation STAT1 EPHB2 22110388 1058552 Positive_regulation STAT1 EPHB2 23825585 2809697 Positive_regulation STAT1 EPHB2 23825585 2809727 Positive_regulation STAT1 EPHB2 23825585 2809728 Positive_regulation STAT1 EPHB2 23825585 2809757 Positive_regulation STAT1 EPHB2 24799982 2228695 Positive_regulation STAT1 EPHB2 24821075 1087355 Positive_regulation STAT1 MAP2K6 23825585 2809703 Positive_regulation STAT1 MAP2K6 23825585 2809718 Positive_regulation STAT1 MAP2K6 23825585 2809743 Positive_regulation STAT1 MAP2K6 23825585 2809744 Positive_regulation STAT1 MAP2K6 23825585 2809745 Positive_regulation STAT1 MAP2K6 23825585 2809763 Positive_regulation STAT1 PLAU 23984088 1150906 Positive_regulation STAT1 STAT4 17846149 1547004 Positive_regulation STAT1 STAT4 24058795 1705961 Positive_regulation STAT1 STAT4 25259790 3010653 Positive_regulation STAT1 TGM2 23865481 344246 Positive_regulation STAT1 TLR7 15851485 1535643 Positive_regulation STAT1 TLR7 25400638 915181 Positive_regulation STAT1 TNF 22096344 1628221 Positive_regulation STAT1 TNF 22096344 1628230 Positive_regulation STAT1 TNF 22547990 3152591 Positive_regulation STAT1 TNF 22937039 2682770 Positive_regulation STAT1 TNF 23071392 1137170 Positive_regulation STAT1 TNF 23170143 1024272 Positive_regulation STAT1 TNF 24009872 204149 Positive_regulation STAT1 TNF 24009872 204152 Positive_regulation STAT1 TNF 24818101 947829 Positive_regulation STAT1 TNF 25629010 865450 Positive_regulation STAT1 TNF PMC3332453 134781 Positive_regulation STAT2 EPHB2 24821075 1087356 Positive_regulation STAT2 STAT4 24913037 273813 Positive_regulation STAT3 CAPN8 22937084 2682856 Positive_regulation STAT3 CAPN8 25352693 1713502 Positive_regulation STAT3 CCND1 22754280 1224428 Positive_regulation STAT3 CCND1 24743777 504259 Positive_regulation STAT3 CCND1 25593999 2173511 Positive_regulation STAT3 CEACAM6 22905257 2675872 Positive_regulation STAT3 EDN2 22128240 1913118 Positive_regulation STAT3 EPHB2 17616983 2289420 Positive_regulation STAT3 EPHB2 21103345 2483801 Positive_regulation STAT3 EPHB2 21254404 775741 Positive_regulation STAT3 EPHB2 21486497 400778 Positive_regulation STAT3 EPHB2 21494621 2513371 Positive_regulation STAT3 EPHB2 21526200 2514088 Positive_regulation STAT3 EPHB2 21738764 2533748 Positive_regulation STAT3 EPHB2 21909139 2142512 Positive_regulation STAT3 EPHB2 22213560 3171730 Positive_regulation STAT3 EPHB2 23782265 151694 Positive_regulation STAT3 EPHB2 24312439 2889350 Positive_regulation STAT3 EPHB2 24312439 2889351 Positive_regulation STAT3 EPHB2 24312439 2889466 Positive_regulation STAT3 EPHB2 24423131 1507489 Positive_regulation STAT3 EPHB2 24423131 1507563 Positive_regulation STAT3 FAS 24058807 1706250 Positive_regulation STAT3 FOXO1 16287709 1538365 Positive_regulation STAT3 FOXO1 17684549 2377527 Positive_regulation STAT3 HBEGF 20738867 855082 Positive_regulation STAT3 IL6R 20819239 257219 Positive_regulation STAT3 IL6R 22046242 2566197 Positive_regulation STAT3 MAP2K6 21909139 2142518 Positive_regulation STAT3 MAP2K6 22213560 3171736 Positive_regulation STAT3 MAP2K6 23251519 2728733 Positive_regulation STAT3 MAP2K6 24312439 2889363 Positive_regulation STAT3 MAP2K6 24312439 2889364 Positive_regulation STAT3 MAP2K6 24710357 2949625 Positive_regulation STAT3 MMP7 21991388 2561753 Positive_regulation STAT3 PECAM1 24734240 188951 Positive_regulation STAT3 RORC 22132325 1686795 Positive_regulation STAT3 RORC 24611151 588848 Positive_regulation STAT3 STAT4 20454646 1215266 Positive_regulation STAT3 STAT4 21297902 496757 Positive_regulation STAT3 STAT4 23345540 2209507 Positive_regulation STAT3 STAT4 25259790 3010659 Positive_regulation STAT3 STK39 21994618 3219307 Positive_regulation STAT3 STK39 21994618 3219357 Positive_regulation STAT3 TLR7 23967307 2835855 Positive_regulation STAT3 TLR7 23967307 2835874 Positive_regulation STAT3 TLR7 23967307 2836034 Positive_regulation STAT3 TNF 20205746 1656134 Positive_regulation STAT3 TNF 20205746 1656139 Positive_regulation STAT3 TNF 20205746 1656152 Positive_regulation STAT3 TNF 20680494 1654496 Positive_regulation STAT3 TNF 21637744 2525878 Positive_regulation STAT3 TNF 21637744 2525879 Positive_regulation STAT3 TNF 21637744 2525935 Positive_regulation STAT3 TNF 22351606 778117 Positive_regulation STAT3 TNF 22351606 778181 Positive_regulation STAT3 TNF 22684844 778769 Positive_regulation STAT3 TNF 23170143 1024273 Positive_regulation STAT3 TNF 23236394 2726123 Positive_regulation STAT3 TNF 23236394 2726124 Positive_regulation STAT3 TNF 23236394 2726125 Positive_regulation STAT3 TNF 23236394 2726126 Positive_regulation STAT3 TNF 23236394 2726127 Positive_regulation STAT3 TNF 23236394 2726128 Positive_regulation STAT3 TNF 23236394 2726134 Positive_regulation STAT3 TNF 23236394 2726135 Positive_regulation STAT3 TNF 23236394 2726136 Positive_regulation STAT3 TNF 23236394 2726137 Positive_regulation STAT3 TNF 23236394 2726138 Positive_regulation STAT3 TNF 23236394 2726139 Positive_regulation STAT3 TNF 23236394 2726142 Positive_regulation STAT3 TNF 23236394 2726143 Positive_regulation STAT3 TNF 23236394 2726144 Positive_regulation STAT3 TNF 23236394 2726154 Positive_regulation STAT3 TNF 23236394 2726155 Positive_regulation STAT3 TNF 23236394 2726156 Positive_regulation STAT3 TNF 23236394 2726163 Positive_regulation STAT3 TNF 23236394 2726164 Positive_regulation STAT3 TNF 23236394 2726172 Positive_regulation STAT3 TNF 23236394 2726173 Positive_regulation STAT3 TNF 23335978 2741181 Positive_regulation STAT3 TNF 23554905 2773650 Positive_regulation STAT3 TNF 23853776 1495340 Positive_regulation STAT3 TNF 24244348 2879464 Positive_regulation STAT3 TNF 24244348 2879465 Positive_regulation STAT3 TNF 24244348 2879466 Positive_regulation STAT3 TNF 24244348 2879467 Positive_regulation STAT3 TNF 24244348 2879468 Positive_regulation STAT3 TNF 24244348 2879479 Positive_regulation STAT3 TNF 24244348 2879480 Positive_regulation STAT3 TNF 24244348 2879481 Positive_regulation STAT3 TNF 24244348 2879487 Positive_regulation STAT3 TNF 24244348 2879488 Positive_regulation STAT3 TNF 24244348 2879505 Positive_regulation STAT3 TNF 24244348 2879506 Positive_regulation STAT3 TNF 24244348 2879518 Positive_regulation STAT3 TNF 24244348 2879519 Positive_regulation STAT3 TNF 24244348 2879536 Positive_regulation STAT3 TNF 24244348 2879537 Positive_regulation STAT3 TNF 24244348 2879540 Positive_regulation STAT3 TNF 24244348 2879544 Positive_regulation STAT3 WIF1 23192652 1244036 Positive_regulation STAT4 ANXA6 22566914 899997 Positive_regulation STAT4 CALML3 11257135 1519085 Positive_regulation STAT4 CD28 24842371 1576362 Positive_regulation STAT4 CD4 10209051 1511649 Positive_regulation STAT4 CDK9 25259790 3010666 Positive_regulation STAT4 DEF6 10449525 1512290 Positive_regulation STAT4 DEF8 10449525 1512289 Positive_regulation STAT4 ETS1 15728239 1534712 Positive_regulation STAT4 ETS1 15728239 1534724 Positive_regulation STAT4 ETV1 25126585 1622884 Positive_regulation STAT4 ETV2 25126585 1622885 Positive_regulation STAT4 ETV3 25126585 1622886 Positive_regulation STAT4 ETV4 25126585 1622887 Positive_regulation STAT4 ETV5 25126585 1622888 Positive_regulation STAT4 ETV6 25126585 1622889 Positive_regulation STAT4 ETV7 25126585 1622883 Positive_regulation STAT4 GGT2 22729903 1832223 Positive_regulation STAT4 IFN1@ 24455433 3151175 Positive_regulation STAT4 IFNAR1 24058798 1706010 Positive_regulation STAT4 IFNG 18803832 111216 Positive_regulation STAT4 IFNG 20111681 1089223 Positive_regulation STAT4 IFNR PMC4033917 2245639 Positive_regulation STAT4 IL10 21396113 121763 Positive_regulation STAT4 IL10 22566914 899998 Positive_regulation STAT4 IL11 21396113 121764 Positive_regulation STAT4 IL12A 10190904 1511363 Positive_regulation STAT4 IL12A 10190904 1511376 Positive_regulation STAT4 IL12A 10587348 1513263 Positive_regulation STAT4 IL12A 10704465 1514541 Positive_regulation STAT4 IL12A 10952721 1516578 Positive_regulation STAT4 IL12A 10952721 1516642 Positive_regulation STAT4 IL12A 10952721 1516676 Positive_regulation STAT4 IL12A 11034602 1517589 Positive_regulation STAT4 IL12A 11034602 1517712 Positive_regulation STAT4 IL12A 11094415 98077 Positive_regulation STAT4 IL12A 11094427 98117 Positive_regulation STAT4 IL12A 11405550 1737786 Positive_regulation STAT4 IL12A 12370258 1525014 Positive_regulation STAT4 IL12A 15225360 101239 Positive_regulation STAT4 IL12A 15526047 2368209 Positive_regulation STAT4 IL12A 15535835 101855 Positive_regulation STAT4 IL12A 16157683 1537166 Positive_regulation STAT4 IL12A 16520391 1539673 Positive_regulation STAT4 IL12A 16542479 105396 Positive_regulation STAT4 IL12A 16717115 1540375 Positive_regulation STAT4 IL12A 17296790 1544467 Positive_regulation STAT4 IL12A 18404423 3087129 Positive_regulation STAT4 IL12A 18404423 3087170 Positive_regulation STAT4 IL12A 18803832 111214 Positive_regulation STAT4 IL12A 19622600 811370 Positive_regulation STAT4 IL12A 19646904 1040069 Positive_regulation STAT4 IL12A 19646904 1040070 Positive_regulation STAT4 IL12A 19646904 1040071 Positive_regulation STAT4 IL12A 19646904 1040072 Positive_regulation STAT4 IL12A 19646904 1040124 Positive_regulation STAT4 IL12A 20018088 395453 Positive_regulation STAT4 IL12A 20027288 2434800 Positive_regulation STAT4 IL12A 20454450 2449128 Positive_regulation STAT4 IL12A 20454646 1215252 Positive_regulation STAT4 IL12A 20459787 118926 Positive_regulation STAT4 IL12A 20459787 118928 Positive_regulation STAT4 IL12A 20479986 1090094 Positive_regulation STAT4 IL12A 20593019 2454354 Positive_regulation STAT4 IL12A 20885915 631986 Positive_regulation STAT4 IL12A 21044323 366143 Positive_regulation STAT4 IL12A 21205293 3111853 Positive_regulation STAT4 IL12A 21297902 496761 Positive_regulation STAT4 IL12A 21559410 2519176 Positive_regulation STAT4 IL12A 21635716 122593 Positive_regulation STAT4 IL12A 22110388 1058553 Positive_regulation STAT4 IL12A 22132325 1686780 Positive_regulation STAT4 IL12A 22474485 634227 Positive_regulation STAT4 IL12A 22493582 956812 Positive_regulation STAT4 IL12A 22566829 898647 Positive_regulation STAT4 IL12A 22566904 899790 Positive_regulation STAT4 IL12A 22566904 899798 Positive_regulation STAT4 IL12A 22566914 899999 Positive_regulation STAT4 IL12A 22723880 2654986 Positive_regulation STAT4 IL12A 22731402 521294 Positive_regulation STAT4 IL12A 22737174 636394 Positive_regulation STAT4 IL12A 23064011 30887 Positive_regulation STAT4 IL12A 23300570 2733853 Positive_regulation STAT4 IL12A 23341860 2220439 Positive_regulation STAT4 IL12A 23346085 905778 Positive_regulation STAT4 IL12A 23386861 883425 Positive_regulation STAT4 IL12A 23450696 906188 Positive_regulation STAT4 IL12A 23475182 1958630 Positive_regulation STAT4 IL12A 23547098 1571022 Positive_regulation STAT4 IL12A 23555662 2774768 Positive_regulation STAT4 IL12A 23671392 2121305 Positive_regulation STAT4 IL12A 23675434 2792919 Positive_regulation STAT4 IL12A 23933255 608933 Positive_regulation STAT4 IL12A 23971052 183265 Positive_regulation STAT4 IL12A 23994464 1051368 Positive_regulation STAT4 IL12A 24058793 1705870 Positive_regulation STAT4 IL12A 24058793 1705919 Positive_regulation STAT4 IL12A 24058795 1705946 Positive_regulation STAT4 IL12A 24058795 1705952 Positive_regulation STAT4 IL12A 24058800 1706070 Positive_regulation STAT4 IL12A 24069552 1706779 Positive_regulation STAT4 IL12A 24097067 1951588 Positive_regulation STAT4 IL12A 24264401 728830 Positive_regulation STAT4 IL12A 24322444 1122011 Positive_regulation STAT4 IL12A 24363024 488371 Positive_regulation STAT4 IL12A 24391825 2904652 Positive_regulation STAT4 IL12A 24416649 1708323 Positive_regulation STAT4 IL12A 24455433 3151143 Positive_regulation STAT4 IL12A 24829749 1623481 Positive_regulation STAT4 IL12A 25076948 913557 Positive_regulation STAT4 IL12A 25259790 3010641 Positive_regulation STAT4 IL12A 25328554 2220229 Positive_regulation STAT4 IL12A 25412660 613034 Positive_regulation STAT4 IL12A 25428805 349635 Positive_regulation STAT4 IL12A 25569146 2301586 Positive_regulation STAT4 IL12A 7722452 1591963 Positive_regulation STAT4 IL12A 7722452 1591973 Positive_regulation STAT4 IL12A 7722452 1591974 Positive_regulation STAT4 IL12A 7722452 1591975 Positive_regulation STAT4 IL12A 8666939 1597344 Positive_regulation STAT4 IL12A 9120388 1600983 Positive_regulation STAT4 IL12A 9120388 1600984 Positive_regulation STAT4 IL12A 9120388 1601005 Positive_regulation STAT4 IL12A 9120388 1601021 Positive_regulation STAT4 IL12A 9743537 1603891 Positive_regulation STAT4 IL12A PMC2525586 1605545 Positive_regulation STAT4 IL12A PMC2588673 3230297 Positive_regulation STAT4 IL12B 10190904 1511364 Positive_regulation STAT4 IL12B 10190904 1511377 Positive_regulation STAT4 IL12B 10587348 1513264 Positive_regulation STAT4 IL12B 10704465 1514542 Positive_regulation STAT4 IL12B 10952721 1516579 Positive_regulation STAT4 IL12B 10952721 1516643 Positive_regulation STAT4 IL12B 10952721 1516677 Positive_regulation STAT4 IL12B 11034602 1517590 Positive_regulation STAT4 IL12B 11034602 1517713 Positive_regulation STAT4 IL12B 11094415 98078 Positive_regulation STAT4 IL12B 11094427 98118 Positive_regulation STAT4 IL12B 11405550 1737787 Positive_regulation STAT4 IL12B 12370258 1525015 Positive_regulation STAT4 IL12B 15225360 101240 Positive_regulation STAT4 IL12B 15526047 2368210 Positive_regulation STAT4 IL12B 15535835 101856 Positive_regulation STAT4 IL12B 16157683 1537167 Positive_regulation STAT4 IL12B 16520391 1539674 Positive_regulation STAT4 IL12B 16542479 105397 Positive_regulation STAT4 IL12B 16717115 1540376 Positive_regulation STAT4 IL12B 17296790 1544468 Positive_regulation STAT4 IL12B 18404423 3087130 Positive_regulation STAT4 IL12B 18404423 3087171 Positive_regulation STAT4 IL12B 18803832 111215 Positive_regulation STAT4 IL12B 19114665 1553263 Positive_regulation STAT4 IL12B 19622600 811371 Positive_regulation STAT4 IL12B 19646904 1040073 Positive_regulation STAT4 IL12B 19646904 1040074 Positive_regulation STAT4 IL12B 19646904 1040075 Positive_regulation STAT4 IL12B 19646904 1040076 Positive_regulation STAT4 IL12B 19646904 1040125 Positive_regulation STAT4 IL12B 20018088 395454 Positive_regulation STAT4 IL12B 20027288 2434801 Positive_regulation STAT4 IL12B 20454450 2449129 Positive_regulation STAT4 IL12B 20454646 1215253 Positive_regulation STAT4 IL12B 20454646 1215271 Positive_regulation STAT4 IL12B 20459787 118927 Positive_regulation STAT4 IL12B 20459787 118929 Positive_regulation STAT4 IL12B 20479986 1090095 Positive_regulation STAT4 IL12B 20593019 2454355 Positive_regulation STAT4 IL12B 20885915 631987 Positive_regulation STAT4 IL12B 21044323 366144 Positive_regulation STAT4 IL12B 21205293 3111854 Positive_regulation STAT4 IL12B 21297902 496762 Positive_regulation STAT4 IL12B 21559410 2519177 Positive_regulation STAT4 IL12B 21635716 122594 Positive_regulation STAT4 IL12B 21791059 390986 Positive_regulation STAT4 IL12B 22022372 2562977 Positive_regulation STAT4 IL12B 22110388 1058554 Positive_regulation STAT4 IL12B 22132325 1686781 Positive_regulation STAT4 IL12B 22474485 634228 Positive_regulation STAT4 IL12B 22493582 956813 Positive_regulation STAT4 IL12B 22566829 898648 Positive_regulation STAT4 IL12B 22566904 899791 Positive_regulation STAT4 IL12B 22566904 899799 Positive_regulation STAT4 IL12B 22566914 900000 Positive_regulation STAT4 IL12B 22723880 2654987 Positive_regulation STAT4 IL12B 22731402 521295 Positive_regulation STAT4 IL12B 22737174 636395 Positive_regulation STAT4 IL12B 23064011 30888 Positive_regulation STAT4 IL12B 23300570 2733854 Positive_regulation STAT4 IL12B 23341860 2220440 Positive_regulation STAT4 IL12B 23346085 905779 Positive_regulation STAT4 IL12B 23386861 883426 Positive_regulation STAT4 IL12B 23450696 906189 Positive_regulation STAT4 IL12B 23469228 2763554 Positive_regulation STAT4 IL12B 23469228 2763564 Positive_regulation STAT4 IL12B 23469228 2763580 Positive_regulation STAT4 IL12B 23475182 1958631 Positive_regulation STAT4 IL12B 23547098 1571023 Positive_regulation STAT4 IL12B 23555662 2774769 Positive_regulation STAT4 IL12B 23671392 2121306 Positive_regulation STAT4 IL12B 23675434 2792920 Positive_regulation STAT4 IL12B 23933255 608934 Positive_regulation STAT4 IL12B 23971052 183266 Positive_regulation STAT4 IL12B 23994464 1051369 Positive_regulation STAT4 IL12B 24058793 1705871 Positive_regulation STAT4 IL12B 24058793 1705902 Positive_regulation STAT4 IL12B 24058793 1705920 Positive_regulation STAT4 IL12B 24058793 1705921 Positive_regulation STAT4 IL12B 24058795 1705947 Positive_regulation STAT4 IL12B 24058795 1705953 Positive_regulation STAT4 IL12B 24058796 1706001 Positive_regulation STAT4 IL12B 24058800 1706071 Positive_regulation STAT4 IL12B 24069552 1706780 Positive_regulation STAT4 IL12B 24097067 1951589 Positive_regulation STAT4 IL12B 24264401 728831 Positive_regulation STAT4 IL12B 24322444 1122012 Positive_regulation STAT4 IL12B 24363024 488372 Positive_regulation STAT4 IL12B 24391825 2904653 Positive_regulation STAT4 IL12B 24416649 1708324 Positive_regulation STAT4 IL12B 24455433 3151144 Positive_regulation STAT4 IL12B 24829749 1623482 Positive_regulation STAT4 IL12B 25076948 913558 Positive_regulation STAT4 IL12B 25259790 3010642 Positive_regulation STAT4 IL12B 25328554 2220230 Positive_regulation STAT4 IL12B 25412660 613035 Positive_regulation STAT4 IL12B 25428805 349636 Positive_regulation STAT4 IL12B 25569146 2301587 Positive_regulation STAT4 IL12B 7722452 1591964 Positive_regulation STAT4 IL12B 7722452 1591976 Positive_regulation STAT4 IL12B 7722452 1591977 Positive_regulation STAT4 IL12B 7722452 1591978 Positive_regulation STAT4 IL12B 8666939 1597345 Positive_regulation STAT4 IL12B 9120388 1600985 Positive_regulation STAT4 IL12B 9120388 1600986 Positive_regulation STAT4 IL12B 9120388 1601006 Positive_regulation STAT4 IL12B 9120388 1601022 Positive_regulation STAT4 IL12B 9743537 1603892 Positive_regulation STAT4 IL12B PMC2525586 1605546 Positive_regulation STAT4 IL12B PMC2588673 3230298 Positive_regulation STAT4 IL12RB1 23028408 2219931 Positive_regulation STAT4 IL12RB2 23028408 2219932 Positive_regulation STAT4 IL13 21396113 121765 Positive_regulation STAT4 IL15 21396113 121766 Positive_regulation STAT4 IL16 21396113 121767 Positive_regulation STAT4 IL17D 25126585 1622966 Positive_regulation STAT4 IL18 20053303 118052 Positive_regulation STAT4 IL18 21396113 121768 Positive_regulation STAT4 IL19 21396113 121769 Positive_regulation STAT4 IL2 21396113 121770 Positive_regulation STAT4 IL2 24363024 488373 Positive_regulation STAT4 IL20 21396113 121771 Positive_regulation STAT4 IL21 21396113 121772 Positive_regulation STAT4 IL22 21396113 121755 Positive_regulation STAT4 IL23A 15225360 101238 Positive_regulation STAT4 IL23A 19114665 1553262 Positive_regulation STAT4 IL23A 20454646 1215270 Positive_regulation STAT4 IL23A 21044323 366142 Positive_regulation STAT4 IL23A 21635716 122592 Positive_regulation STAT4 IL23A 21791059 390985 Positive_regulation STAT4 IL23A 22022372 2562976 Positive_regulation STAT4 IL23A 23469228 2763553 Positive_regulation STAT4 IL23A 23469228 2763563 Positive_regulation STAT4 IL23A 23469228 2763579 Positive_regulation STAT4 IL23A 23675434 2792918 Positive_regulation STAT4 IL23A 23971052 183264 Positive_regulation STAT4 IL23A 24058793 1705901 Positive_regulation STAT4 IL23A 24058793 1705918 Positive_regulation STAT4 IL23A 24058796 1706000 Positive_regulation STAT4 IL23A 25328554 2220228 Positive_regulation STAT4 IL24 21396113 121753 Positive_regulation STAT4 IL25 21396113 121754 Positive_regulation STAT4 IL26 21396113 121759 Positive_regulation STAT4 IL27 21396113 121760 Positive_regulation STAT4 IL3 21396113 121773 Positive_regulation STAT4 IL31 21396113 121761 Positive_regulation STAT4 IL32 21396113 121758 Positive_regulation STAT4 IL33 21396113 121757 Positive_regulation STAT4 IL34 21396113 121762 Positive_regulation STAT4 IL37 21396113 121756 Positive_regulation STAT4 IL4 21358638 1955107 Positive_regulation STAT4 IL4 21396113 121774 Positive_regulation STAT4 IL5 21396113 121775 Positive_regulation STAT4 IL6 21358638 1955087 Positive_regulation STAT4 IL6 21396113 121776 Positive_regulation STAT4 IL6 23994464 1051370 Positive_regulation STAT4 IL6ST 24058793 1705872 Positive_regulation STAT4 IL6ST 25259790 3010643 Positive_regulation STAT4 IL6ST 25259790 3010667 Positive_regulation STAT4 IL7 21396113 121777 Positive_regulation STAT4 IL8 21396113 121778 Positive_regulation STAT4 IL9 21396113 121779 Positive_regulation STAT4 IRAK1 24690905 2947283 Positive_regulation STAT4 JAK2 22110388 1058568 Positive_regulation STAT4 MAP2K1 24106497 696933 Positive_regulation STAT4 MAP3K8 19001140 1552754 Positive_regulation STAT4 MAP3K8 19001140 1552785 Positive_regulation STAT4 MSC 24876666 1758845 Positive_regulation STAT4 MSC 24876666 1758848 Positive_regulation STAT4 MYD88 20111681 1089224 Positive_regulation STAT4 NELFCD 23720660 907046 Positive_regulation STAT4 NELFCD 24188121 1728383 Positive_regulation STAT4 PIM1 23209281 1205794 Positive_regulation STAT4 PIM2 23209281 1205795 Positive_regulation STAT4 PIM3 23209281 1205793 Positive_regulation STAT4 POLDIP2 11094415 98076 Positive_regulation STAT4 PPP2CA 17875674 1547020 Positive_regulation STAT4 PPP2R1A 17875674 1547021 Positive_regulation STAT4 PPP2R2B 17875674 1547022 Positive_regulation STAT4 SOCS3 23346085 905777 Positive_regulation STAT4 STAT1 17846149 1547005 Positive_regulation STAT4 STAT1 24058795 1705945 Positive_regulation STAT4 STAT1 24058795 1705950 Positive_regulation STAT4 STAT1 24058795 1705962 Positive_regulation STAT4 STAT1 25259790 3010664 Positive_regulation STAT4 STAT2 23626590 906832 Positive_regulation STAT4 STAT2 24062747 909026 Positive_regulation STAT4 STAT3 20454646 1215269 Positive_regulation STAT4 STAT3 21297902 496760 Positive_regulation STAT4 STAT3 25259790 3010665 Positive_regulation STAT4 STAT4 10209051 1511648 Positive_regulation STAT4 STAT4 12370258 1525010 Positive_regulation STAT4 STAT4 20843320 1858930 Positive_regulation STAT4 STAT4 22729903 1832222 Positive_regulation STAT4 STAT5A 24058795 1705951 Positive_regulation STAT4 STAT6 10449525 1512275 Positive_regulation STAT4 STAT6 9743537 1603890 Positive_regulation STAT4 TBX21 25126585 1622882 Positive_regulation STAT4 TIMP1 23555662 2774778 Positive_regulation STAT4 TNF 10880525 1516047 Positive_regulation STAT4 TNF 23170143 1024274 Positive_regulation STAT4 TWIST1 22969750 877131 Positive_regulation STAT4 TYK2 22110388 1058567 Positive_regulation STAT4 TYK2 22723949 2655359 Positive_regulation STAT5A ANGPT1 22792187 2661139 Positive_regulation STAT5A ANGPT1 22792187 2661199 Positive_regulation STAT5A CAPN8 25352693 1713516 Positive_regulation STAT5A CCL17 23435120 1958569 Positive_regulation STAT5A CTGF 20497571 285129 Positive_regulation STAT5A EDN2 22838633 649205 Positive_regulation STAT5A ID1 22475005 174986 Positive_regulation STAT5A STAT4 23345540 2209509 Positive_regulation STAT5A STAT4 24058795 1705954 Positive_regulation STAT6 CAPN8 24707444 1490752 Positive_regulation STAT6 MAP2K6 25071444 869824 Positive_regulation STAT6 MMP28 12093868 1523743 Positive_regulation STAT6 MMP7 12093868 1523760 Positive_regulation STAT6 STAT4 10449525 1512276 Positive_regulation STAT6 STAT4 9743537 1603893 Positive_regulation STEAP4 TNF 24643198 1062544 Positive_regulation STEAP4 TNF 24643198 1062546 Positive_regulation STIM1 EPHB2 22298426 1799958 Positive_regulation STIP1 EPHB2 20093365 1169114 Positive_regulation STIP1 MMP28 23836498 781130 Positive_regulation STIP1 MMP7 23836498 781148 Positive_regulation STK11 AXIN2 24904600 970680 Positive_regulation STK11 F2R 17470638 1340122 Positive_regulation STK11 F2R 25437306 762617 Positive_regulation STK11 FOXO1 22412893 2609560 Positive_regulation STK11 MAP2K6 24928904 1487986 Positive_regulation STK32C TNF 24944768 2115577 Positive_regulation STK39 AHSA1 20187982 328579 Positive_regulation STK39 AKT1 19707392 175775 Positive_regulation STK39 AKT1 22402981 93040 Positive_regulation STK39 AKT1 23232026 2181939 Positive_regulation STK39 AKT1 24967401 193202 Positive_regulation STK39 AKT2 19707392 175776 Positive_regulation STK39 AKT2 22402981 93041 Positive_regulation STK39 AKT2 23232026 2181940 Positive_regulation STK39 AKT2 24967401 193203 Positive_regulation STK39 AKT3 19707392 175777 Positive_regulation STK39 AKT3 22402981 93042 Positive_regulation STK39 AKT3 23232026 2181941 Positive_regulation STK39 AKT3 24967401 193204 Positive_regulation STK39 ANGPT2 21217931 1709818 Positive_regulation STK39 ASCL2 23899788 1109526 Positive_regulation STK39 ATP6V0D1 20422042 2447703 Positive_regulation STK39 BMP1 21789165 2537595 Positive_regulation STK39 BMP1 8609176 1451271 Positive_regulation STK39 BMP10 21789165 2537603 Positive_regulation STK39 BMP10 8609176 1451279 Positive_regulation STK39 BMP15 21789165 2537596 Positive_regulation STK39 BMP15 8609176 1451272 Positive_regulation STK39 BMP2 19587783 2421122 Positive_regulation STK39 BMP2 21789165 2537597 Positive_regulation STK39 BMP2 8609176 1451273 Positive_regulation STK39 BMP3 21789165 2537598 Positive_regulation STK39 BMP3 8609176 1451274 Positive_regulation STK39 BMP4 21789165 2537599 Positive_regulation STK39 BMP4 8609176 1451275 Positive_regulation STK39 BMP5 21789165 2537600 Positive_regulation STK39 BMP5 8609176 1451276 Positive_regulation STK39 BMP6 21789165 2537601 Positive_regulation STK39 BMP6 8609176 1451277 Positive_regulation STK39 BMP7 21789165 2537602 Positive_regulation STK39 BMP7 8609176 1451278 Positive_regulation STK39 BRAF 22792460 622966 Positive_regulation STK39 CA2 22246465 2170828 Positive_regulation STK39 CA2 25621127 1494799 Positive_regulation STK39 CALM3 17026765 1845610 Positive_regulation STK39 CALM3 21639921 734142 Positive_regulation STK39 CALM3 22246465 2170829 Positive_regulation STK39 CALM3 22645613 1673934 Positive_regulation STK39 CALM3 23269878 1712080 Positive_regulation STK39 CALM3 23383130 2748069 Positive_regulation STK39 CALM3 23678289 1061393 Positive_regulation STK39 CALM3 24860643 1770130 Positive_regulation STK39 CALM3 25548518 743614 Positive_regulation STK39 CCNT1 22860019 2671101 Positive_regulation STK39 CDC42 22940759 857483 Positive_regulation STK39 CDC42 9763437 1471125 Positive_regulation STK39 CDK9 22860019 2671102 Positive_regulation STK39 CORT 22509272 2618495 Positive_regulation STK39 CORT 24348341 932881 Positive_regulation STK39 GRN 22860019 2671103 Positive_regulation STK39 HOXD13 24804192 1078523 Positive_regulation STK39 HRAS 21754924 696730 Positive_regulation STK39 HRAS 21953712 776759 Positive_regulation STK39 HRAS 23720710 944200 Positive_regulation STK39 HRAS 24422672 1618567 Positive_regulation STK39 HRAS 24422672 1618582 Positive_regulation STK39 HSP90AB1 22073363 806673 Positive_regulation STK39 IER2 1309816 1297431 Positive_regulation STK39 IER3 1309816 1297432 Positive_regulation STK39 IER5 1309816 1297433 Positive_regulation STK39 IGF1 24696681 1074048 Positive_regulation STK39 IL3 14970183 1531457 Positive_regulation STK39 INHBA 21586099 467725 Positive_regulation STK39 INS 16120010 2368438 Positive_regulation STK39 INS 1689732 1331908 Positive_regulation STK39 INS 19769782 659335 Positive_regulation STK39 INS 22412882 2609469 Positive_regulation STK39 INS 23610527 731425 Positive_regulation STK39 INS 8384652 1595081 Positive_regulation STK39 KRAS 21754924 696731 Positive_regulation STK39 KRAS 21953712 776760 Positive_regulation STK39 KRAS 22451720 1567915 Positive_regulation STK39 KRAS 22714415 3164071 Positive_regulation STK39 KRAS 23720710 944201 Positive_regulation STK39 MAP3K7 22969770 904296 Positive_regulation STK39 MNAT1 20422042 2447704 Positive_regulation STK39 MRE11A 23975433 2153318 Positive_regulation STK39 MST1 15363108 248476 Positive_regulation STK39 MST1 15363108 248528 Positive_regulation STK39 MST1 15363108 248546 Positive_regulation STK39 MST1R 15363108 248477 Positive_regulation STK39 NBN 23975433 2153319 Positive_regulation STK39 NCK1 21808734 1686484 Positive_regulation STK39 NRAS 21754924 696732 Positive_regulation STK39 NRAS 21953712 776761 Positive_regulation STK39 NRAS 23720710 944202 Positive_regulation STK39 PCNA 25010342 2360286 Positive_regulation STK39 PCNA 25161228 162722 Positive_regulation STK39 PCNA 25161228 162723 Positive_regulation STK39 PI3 18949077 2208080 Positive_regulation STK39 PIK3C3 22848740 2670311 Positive_regulation STK39 PIK3CA 11506482 419637 Positive_regulation STK39 PIK3CA 19365570 1909103 Positive_regulation STK39 PIK3CA 20856791 2120697 Positive_regulation STK39 PIK3CA 21808734 1686485 Positive_regulation STK39 PIK3CA 21904677 1139465 Positive_regulation STK39 PIK3CA 22496919 2618022 Positive_regulation STK39 PIK3CA 23874591 2821774 Positive_regulation STK39 PIK3CA 24049458 491037 Positive_regulation STK39 PIK3CA 24611016 2122807 Positive_regulation STK39 PIK3R1 11506482 419638 Positive_regulation STK39 PIK3R1 19365570 1909104 Positive_regulation STK39 PIK3R1 20856791 2120698 Positive_regulation STK39 PIK3R1 21808734 1686486 Positive_regulation STK39 PIK3R1 21904677 1139466 Positive_regulation STK39 PIK3R1 22496919 2618023 Positive_regulation STK39 PIK3R1 23874591 2821775 Positive_regulation STK39 PIK3R1 24049458 491038 Positive_regulation STK39 PIK3R1 24611016 2122808 Positive_regulation STK39 PIK3R4 22848740 2670312 Positive_regulation STK39 PRKAA1 22018140 244474 Positive_regulation STK39 PRKAA2 22018140 244475 Positive_regulation STK39 PRKAB1 22018140 244476 Positive_regulation STK39 PRKAB2 22018140 244477 Positive_regulation STK39 PRKAG1 22018140 244478 Positive_regulation STK39 PRKAG2 22018140 244479 Positive_regulation STK39 PTGS2 24795889 189934 Positive_regulation STK39 RAC1 22940759 857484 Positive_regulation STK39 RAC1 9763437 1471126 Positive_regulation STK39 RAC2 22940759 857485 Positive_regulation STK39 RAC2 9763437 1471127 Positive_regulation STK39 RAC3 22940759 857486 Positive_regulation STK39 RAC3 9763437 1471128 Positive_regulation STK39 RAD50 23975433 2153320 Positive_regulation STK39 RHEB 20808898 2317914 Positive_regulation STK39 RHO 11238445 1267423 Positive_regulation STK39 RHO 11238445 1267424 Positive_regulation STK39 RHO 25143987 3156999 Positive_regulation STK39 RHO 25143987 3157000 Positive_regulation STK39 SLC22A3 24816813 2963172 Positive_regulation STK39 SMO 24550888 880113 Positive_regulation STK39 TAB1 22969770 904295 Positive_regulation STK39 TRAF6 22969770 904294 Positive_regulation STK39 WNK1 25205925 89988 Positive_regulation STK4 FOXO1 22454632 832683 Positive_regulation STK4 FOXO1 24633305 1963985 Positive_regulation STK4 NES 23029267 2695803 Positive_regulation STK4 RASSF10 17174922 665421 Positive_regulation STMN1 IFI27 19643027 325853 Positive_regulation STMN3 ID1 25028095 1875707 Positive_regulation STMN3 ID1 25028095 1875708 Positive_regulation STMN3 ID1 25028095 1875709 Positive_regulation STMN3 ID1 25028095 1875710 Positive_regulation STMN3 ID1 25028095 1875747 Positive_regulation STMN3 ID1 25028095 1875754 Positive_regulation STMN3 ID1 25028095 1875787 Positive_regulation STMN3 ID1 25028095 1875796 Positive_regulation STMN3 ID1 25028095 1875811 Positive_regulation STOML2 EPHB2 23667687 2791987 Positive_regulation STOML2 EPHB2 23667687 2792014 Positive_regulation STRAP SMN2 18791638 2396498 Positive_regulation STRAP SMN2 21339974 1090574 Positive_regulation STRAP SMN2 23615451 1813975 Positive_regulation STRAP SMN2 23615451 1814158 Positive_regulation STS CAPN8 24963283 842305 Positive_regulation STS EPHB2 24096434 93493 Positive_regulation STS IL1B 24701565 188180 Positive_regulation STS PLAGL1 24260468 2884377 Positive_regulation STX6 RAB31 20347926 833505 Positive_regulation SUB1 MAP2K6 19930650 526240 Positive_regulation SUB1 MAP2K6 19930650 526278 Positive_regulation SUDS3 NES 24552625 2013126 Positive_regulation SUDS3 TNF 7931061 1593051 Positive_regulation SULT1A3 MAP2K6 25071492 861184 Positive_regulation SULT2A1 FAS 25250309 873195 Positive_regulation SULT2A1 TNF 24314293 314635 Positive_regulation SUMO1 TNF PMC2833562 134226 Positive_regulation SUMO1 TNF PMC2833562 134227 Positive_regulation SUN1 LINC00284 21627841 287452 Positive_regulation SUN1 LINC00341 21627841 287412 Positive_regulation SUPT16H TNF 23049873 2699757 Positive_regulation SUV39H1 FOXO1 23435416 2151775 Positive_regulation SUV39H1 IFI27 23376847 2151523 Positive_regulation SUZ12 ZFP57 20808772 2472109 Positive_regulation SV2A WNT7A 24403870 684910 Positive_regulation SWI5 FOXO1 21689484 404984 Positive_regulation SWI5 FOXO1 23895232 410590 Positive_regulation SYK CCND1 12470302 350398 Positive_regulation SYK EPHB2 22719740 901955 Positive_regulation SYK ITGB2 20721346 1051410 Positive_regulation SYK NGFR 22880054 2674112 Positive_regulation SYK TLR7 22496641 3055995 Positive_regulation SYK TNF 19151749 2124273 Positive_regulation SYK TNF 25045209 1760131 Positive_regulation SYK TNF 25140116 1761033 Positive_regulation SYN1 EPHB2 17105652 106790 Positive_regulation SYN1 EPHB2 17105652 106865 Positive_regulation SYN1 EPHB2 17105652 106925 Positive_regulation SYN1 EPHB2 17105652 106926 Positive_regulation SYN1 EPHB2 17105652 106941 Positive_regulation SYN1 EPHB2 20162032 927710 Positive_regulation SYN1 EPHB2 22942754 1097322 Positive_regulation SYN1 EPHB2 23840629 2815713 Positive_regulation SYN1 MAP2K6 22942754 1097354 Positive_regulation SYN1 TNF 17105652 106788 Positive_regulation SYN1 TNF 17105652 106789 Positive_regulation SYN1 TNF 17105652 106940 Positive_regulation SYN1 TNF 17105652 106982 Positive_regulation SYN1 TNF 23936437 2830428 Positive_regulation SYN1 TNF 23936437 2830432 Positive_regulation SYN1 WNT7A 21660241 1052692 Positive_regulation SYN1 WNT7A 25170755 3003811 Positive_regulation SYN1 WNT7A 25170755 3003878 Positive_regulation SYN1 WNT7A 25170755 3003886 Positive_regulation SYN1 WNT7A 25170755 3003909 Positive_regulation SYN2 EPHB2 17105652 106803 Positive_regulation SYN2 EPHB2 17105652 106870 Positive_regulation SYN2 EPHB2 17105652 106929 Positive_regulation SYN2 EPHB2 17105652 106930 Positive_regulation SYN2 EPHB2 17105652 106944 Positive_regulation SYN2 EPHB2 20162032 927712 Positive_regulation SYN2 TNF 17105652 106801 Positive_regulation SYN2 TNF 17105652 106802 Positive_regulation SYN2 TNF 17105652 106943 Positive_regulation SYN2 TNF 17105652 106984 Positive_regulation SYN2 TNF 23936437 2830429 Positive_regulation SYN2 TNF 23936437 2830433 Positive_regulation SYN2 WNT7A 25170755 3003910 Positive_regulation SYN3 EPHB2 17105652 106816 Positive_regulation SYN3 EPHB2 17105652 106875 Positive_regulation SYN3 EPHB2 17105652 106933 Positive_regulation SYN3 EPHB2 17105652 106934 Positive_regulation SYN3 EPHB2 17105652 106947 Positive_regulation SYN3 EPHB2 20162032 927714 Positive_regulation SYN3 TNF 17105652 106814 Positive_regulation SYN3 TNF 17105652 106815 Positive_regulation SYN3 TNF 17105652 106946 Positive_regulation SYN3 TNF 17105652 106986 Positive_regulation SYN3 TNF 23936437 2830430 Positive_regulation SYN3 TNF 23936437 2830434 Positive_regulation SYN3 WNT7A 25170755 3003911 Positive_regulation SYNC DES 25394388 5610 Positive_regulation SYNCRIP LAMB3 22160594 1798607 Positive_regulation SYNCRIP TNF 23688423 314163 Positive_regulation SYNCRIP TNF 9382882 1602109 Positive_regulation SYNM APOE 21760988 1052695 Positive_regulation SYNM CALM3 21258328 1966505 Positive_regulation SYNM CD68 22531084 291976 Positive_regulation SYNM EPHB2 23243430 816464 Positive_regulation SYNM KRT10 22366687 1928228 Positive_regulation SYNM MTX1 6945118 443764 Positive_regulation SYNM POU6F1 24667541 2938775 Positive_regulation SYNM PTGS2 21776245 1075806 Positive_regulation SYNM SLPI 18237412 626806 Positive_regulation SYNM SOD1 19695098 626852 Positive_regulation SYNM SOD2 19695098 626853 Positive_regulation SYNM SOD3 19695098 626854 Positive_regulation SYNM WAS 23936144 2829502 Positive_regulation SYNPO TNF 23359116 2744871 Positive_regulation SYNPO TNS1 24967628 2983766 Positive_regulation SYNPO2 NES 11673475 1275782 Positive_regulation SYP EPHB2 18487452 706119 Positive_regulation SYP EPHB2 18487452 706120 Positive_regulation SYP EPHB2 18487452 706121 Positive_regulation SYP NNMT 23764850 562392 Positive_regulation SYP NNMT 23764850 562393 Positive_regulation SYP NNMT 23764850 562412 Positive_regulation SYP NNMT 23764850 562413 Positive_regulation SYP TF 1918133 1363662 Positive_regulation SYT1 ANKRD1 24434510 570879 Positive_regulation SYT1 CD14 23704945 2797056 Positive_regulation SYT1 CTGF 16303051 524652 Positive_regulation SYT1 EPHB2 20038977 1910362 Positive_regulation SYT1 ID1 22139302 1879314 Positive_regulation SYT1 MAP2K6 9841930 1604788 Positive_regulation SYT1 MMP28 15841081 425840 Positive_regulation SYT1 MMP7 15841081 425855 Positive_regulation SYT1 TLR7 23853595 3063014 Positive_regulation SYT1 TLR7 24098413 2856162 Positive_regulation SYT1 TNF 11044363 418024 Positive_regulation SYT1 TNF 11044363 418040 Positive_regulation SYT1 TNF 11481030 312695 Positive_regulation SYT1 TNF 14612916 423852 Positive_regulation SYT1 TNF 15694007 391916 Positive_regulation SYT1 TNF 15694007 391917 Positive_regulation SYT1 TNF 17498291 999374 Positive_regulation SYT1 TNF 17620405 1341837 Positive_regulation SYT1 TNF 18410682 110451 Positive_regulation SYT1 TNF 18410682 110452 Positive_regulation SYT1 TNF 19594939 313130 Positive_regulation SYT1 TNF 20809973 1858359 Positive_regulation SYT1 TNF 20946687 1657229 Positive_regulation SYT1 TNF 20948609 846231 Positive_regulation SYT1 TNF 21060745 1635298 Positive_regulation SYT1 TNF 21199955 1562316 Positive_regulation SYT1 TNF 21556136 2517667 Positive_regulation SYT1 TNF 21572963 2520264 Positive_regulation SYT1 TNF 21572963 2520289 Positive_regulation SYT1 TNF 21572963 2520290 Positive_regulation SYT1 TNF 21572963 2520307 Positive_regulation SYT1 TNF 21673972 2528071 Positive_regulation SYT1 TNF 21673972 2528115 Positive_regulation SYT1 TNF 21765477 2141227 Positive_regulation SYT1 TNF 21765477 2141245 Positive_regulation SYT1 TNF 21765477 2141272 Positive_regulation SYT1 TNF 21904602 2550363 Positive_regulation SYT1 TNF 21904602 2550364 Positive_regulation SYT1 TNF 21904602 2550400 Positive_regulation SYT1 TNF 22076152 2570309 Positive_regulation SYT1 TNF 22096375 1628421 Positive_regulation SYT1 TNF 22128776 1724155 Positive_regulation SYT1 TNF 22128776 1724160 Positive_regulation SYT1 TNF 22128776 1724162 Positive_regulation SYT1 TNF 22194985 2583672 Positive_regulation SYT1 TNF 22231395 14407 Positive_regulation SYT1 TNF 22231395 14408 Positive_regulation SYT1 TNF 22231395 14409 Positive_regulation SYT1 TNF 22231395 14411 Positive_regulation SYT1 TNF 22231395 14412 Positive_regulation SYT1 TNF 22237038 624573 Positive_regulation SYT1 TNF 22313861 3160897 Positive_regulation SYT1 TNF 22384180 2607138 Positive_regulation SYT1 TNF 22396737 2608358 Positive_regulation SYT1 TNF 22396737 2608380 Positive_regulation SYT1 TNF 22426696 14542 Positive_regulation SYT1 TNF 22426696 14554 Positive_regulation SYT1 TNF 22426696 14569 Positive_regulation SYT1 TNF 22701747 2652526 Positive_regulation SYT1 TNF 22754320 1095964 Positive_regulation SYT1 TNF 22754320 1095968 Positive_regulation SYT1 TNF 22754320 1095971 Positive_regulation SYT1 TNF 22768286 2660440 Positive_regulation SYT1 TNF 22768286 2660454 Positive_regulation SYT1 TNF 23071583 2703159 Positive_regulation SYT1 TNF 23071583 2703160 Positive_regulation SYT1 TNF 23284617 2730267 Positive_regulation SYT1 TNF 23284617 2730272 Positive_regulation SYT1 TNF 23285008 2731510 Positive_regulation SYT1 TNF 23317476 1155715 Positive_regulation SYT1 TNF 23317476 1155725 Positive_regulation SYT1 TNF 23317476 1155726 Positive_regulation SYT1 TNF 23343355 1231911 Positive_regulation SYT1 TNF 23414442 1666064 Positive_regulation SYT1 TNF 23437404 2756835 Positive_regulation SYT1 TNF 23536830 2773085 Positive_regulation SYT1 TNF 23573150 818512 Positive_regulation SYT1 TNF 23573150 818513 Positive_regulation SYT1 TNF 23573150 818516 Positive_regulation SYT1 TNF 23573150 818519 Positive_regulation SYT1 TNF 23573150 818520 Positive_regulation SYT1 TNF 23573150 818521 Positive_regulation SYT1 TNF 23593410 2781208 Positive_regulation SYT1 TNF 23637609 3060928 Positive_regulation SYT1 TNF 23861891 2820554 Positive_regulation SYT1 TNF 23861891 2820557 Positive_regulation SYT1 TNF 23922887 2827201 Positive_regulation SYT1 TNF 23922887 2827220 Positive_regulation SYT1 TNF 23935933 2828564 Positive_regulation SYT1 TNF 23935933 2828565 Positive_regulation SYT1 TNF 23935933 2828567 Positive_regulation SYT1 TNF 23971673 3215859 Positive_regulation SYT1 TNF 24024170 3093434 Positive_regulation SYT1 TNF 24024170 3093440 Positive_regulation SYT1 TNF 24061539 1905220 Positive_regulation SYT1 TNF 24244348 2879539 Positive_regulation SYT1 TNF 24348668 3204731 Positive_regulation SYT1 TNF 24371075 1704457 Positive_regulation SYT1 TNF 24371075 1704461 Positive_regulation SYT1 TNF 24386331 2903527 Positive_regulation SYT1 TNF 24502696 1233032 Positive_regulation SYT1 TNF 24502696 1233058 Positive_regulation SYT1 TNF 24502696 1233098 Positive_regulation SYT1 TNF 24502696 1233144 Positive_regulation SYT1 TNF 24502696 1233213 Positive_regulation SYT1 TNF 24502696 1233288 Positive_regulation SYT1 TNF 24587411 2929895 Positive_regulation SYT1 TNF 24616552 1757569 Positive_regulation SYT1 TNF 24616552 1757572 Positive_regulation SYT1 TNF 24729717 1162561 Positive_regulation SYT1 TNF 24824433 2969213 Positive_regulation SYT1 TNF 24864134 1758813 Positive_regulation SYT1 TNF 24864134 1758829 Positive_regulation SYT1 TNF 24876678 1759057 Positive_regulation SYT1 TNF 24926361 844217 Positive_regulation SYT1 TNF 24926361 844218 Positive_regulation SYT1 TNF 24967365 193109 Positive_regulation SYT1 TNF 25017038 1087521 Positive_regulation SYT1 TNF 25025076 194746 Positive_regulation SYT1 TNF 25032222 194871 Positive_regulation SYT1 TNF 25114952 3156799 Positive_regulation SYT1 TNF 25119989 2997187 Positive_regulation SYT1 TNF 25119989 2997189 Positive_regulation SYT1 TNF 25201625 541027 Positive_regulation SYT1 TNF 25239871 32272 Positive_regulation SYT1 TNF 25427002 3030380 Positive_regulation SYT1 TNF 25489420 206901 Positive_regulation SYT1 TNF 25553117 3177740 Positive_regulation SYT1 TNF 25553117 3177741 Positive_regulation SYT1 WNT7A 24403870 684896 Positive_regulation SYT10 WNT7A 24403870 684909 Positive_regulation SYT11 WNT7A 24403870 684906 Positive_regulation SYT12 WNT7A 24403870 684904 Positive_regulation SYT13 WNT7A 24403870 684902 Positive_regulation SYT14 WNT7A 24403870 684912 Positive_regulation SYT15 WNT7A 24403870 684903 Positive_regulation SYT16 WNT7A 24403870 684911 Positive_regulation SYT17 WNT7A 24403870 684913 Positive_regulation SYT2 SYT8 21258358 12394 Positive_regulation SYT2 WNT7A 24403870 684897 Positive_regulation SYT3 WNT7A 24403870 684898 Positive_regulation SYT4 WNT7A 24403870 684899 Positive_regulation SYT5 WNT7A 24403870 684900 Positive_regulation SYT6 WNT7A 24403870 684905 Positive_regulation SYT7 TSPAN1 21041449 1382706 Positive_regulation SYT7 WNT7A 24403870 684901 Positive_regulation SYT8 APP 24086147 2351277 Positive_regulation SYT8 APPL1 24086147 2351217 Positive_regulation SYT8 APPL2 24086147 2351216 Positive_regulation SYT8 CA2 10974000 1262551 Positive_regulation SYT8 CA2 10974000 1262574 Positive_regulation SYT8 CA2 10974000 1262625 Positive_regulation SYT8 CA2 14580108 3228614 Positive_regulation SYT8 CA2 19597565 934570 Positive_regulation SYT8 CA2 20126653 2439961 Positive_regulation SYT8 CA2 21998599 2326886 Positive_regulation SYT8 CA2 22940675 1977938 Positive_regulation SYT8 CA2 22940675 1977939 Positive_regulation SYT8 CA2 22940675 1977995 Positive_regulation SYT8 CA2 22940675 1978064 Positive_regulation SYT8 CA2 23285259 2733134 Positive_regulation SYT8 CA2 24455186 4862 Positive_regulation SYT8 CA2 24957080 1654384 Positive_regulation SYT8 CA2 25206473 2004714 Positive_regulation SYT8 CALM3 24455186 4863 Positive_regulation SYT8 KIF1A 22808098 2664528 Positive_regulation SYT8 PPP3CA 24086147 2351218 Positive_regulation SYT8 PPP3R1 24086147 2351219 Positive_regulation SYT8 SCGB2B3P 10974000 1262552 Positive_regulation SYT8 SCGB2B3P 10974000 1262608 Positive_regulation SYT8 SFRP1 16818724 1330996 Positive_regulation SYT8 SNAPIN 23949442 839319 Positive_regulation SYT8 SNAPIN 23949442 839359 Positive_regulation SYT8 STON1 22808098 2664439 Positive_regulation SYT8 STON2 22808098 2664442 Positive_regulation SYT8 SV2A 19381277 2413400 Positive_regulation SYT8 SV2A 24937314 1156925 Positive_regulation SYT8 SYT1 25565955 872825 Positive_regulation SYT8 SYT2 21258358 12409 Positive_regulation SYT8 UNC119 22808098 2664437 Positive_regulation SYT8 UNC50 22808098 2664438 Positive_regulation SYT8 UNC79 22808098 2664440 Positive_regulation SYT8 UNC80 22808098 2664441 Positive_regulation SYT8 WNT7A 24403870 684907 Positive_regulation SYT9 WNT7A 24403870 684908 Positive_regulation TAB1 STK39 21488180 3232603 Positive_regulation TAB1 TLR7 19234607 2406065 Positive_regulation TAB1 TLR7 23527104 2769400 Positive_regulation TAB1 TLR7 23527104 2769401 Positive_regulation TAB1 TLR7 23760366 2211822 Positive_regulation TAB1 TLR7 24498425 2919819 Positive_regulation TAB1 TLR7 24498425 2919849 Positive_regulation TAB1 TLR7 24586659 2926033 Positive_regulation TAB1 TNF 22313861 3160903 Positive_regulation TAB1 TNF 23240068 2727734 Positive_regulation TAB1 TNF 23300658 2734297 Positive_regulation TAB1 TNF 23300658 2734301 Positive_regulation TAB1 TNF 23331383 1675477 Positive_regulation TAB1 TNF 23844119 2819478 Positive_regulation TAB1 TNF 24535827 1416512 Positive_regulation TAB1 TNFSF10 19421137 2125072 Positive_regulation TAB1 TNFSF10 19421137 2125075 Positive_regulation TAB1 TNFSF10 19421137 2125078 Positive_regulation TAB1 TNFSF10 19421137 2125087 Positive_regulation TAB2 EPHB2 19305426 2124960 Positive_regulation TAB2 TNF 24386633 186127 Positive_regulation TAB2 TNFSF10 22719861 2653288 Positive_regulation TAB2 TNS1 25009550 970906 Positive_regulation TAC1 CTGF 23166366 805580 Positive_regulation TAC3 CTGF 23166366 805582 Positive_regulation TAC4 CTGF 23166366 805584 Positive_regulation TACC2 FOXA1 22125492 2327875 Positive_regulation TACC2 FOXA1 24073287 2853728 Positive_regulation TACC2 FOXA1 24073287 2853731 Positive_regulation TACC2 TGM2 22944909 1890293 Positive_regulation TACC2 TLR7 22216977 1660610 Positive_regulation TACC2 TLR7 22312110 1567128 Positive_regulation TACC2 TLR7 22312110 1567129 Positive_regulation TACC2 TLR7 22312110 1567242 Positive_regulation TACC2 TLR7 22388040 1956576 Positive_regulation TACC2 TLR7 23525517 2162321 Positive_regulation TACC2 TNF 19052667 162861 Positive_regulation TACC3 FOXA1 22125492 2327876 Positive_regulation TACC3 FOXA1 24073287 2853729 Positive_regulation TACC3 FOXA1 24073287 2853732 Positive_regulation TACC3 TGM2 22944909 1890294 Positive_regulation TACC3 TLR7 22216977 1660620 Positive_regulation TACC3 TLR7 22312110 1567148 Positive_regulation TACC3 TLR7 22312110 1567149 Positive_regulation TACC3 TLR7 22312110 1567252 Positive_regulation TACC3 TLR7 22388040 1956586 Positive_regulation TACC3 TLR7 23525517 2162331 Positive_regulation TACC3 TNF 19052667 162862 Positive_regulation TACSTD2 EPHB2 20858281 1859200 Positive_regulation TADA3 TLR7 23273344 312148 Positive_regulation TAF1 TNF 16191192 318574 Positive_regulation TAF1 TNF 19338389 2266445 Positive_regulation TAF10 TNF 16191192 318580 Positive_regulation TAF11 TNF 16191192 318581 Positive_regulation TAF12 TNF 16191192 318582 Positive_regulation TAF13 TNF 16191192 318583 Positive_regulation TAF4 TNF 16191192 318575 Positive_regulation TAF4B TNF 16191192 318576 Positive_regulation TAF5 TNF 16191192 318577 Positive_regulation TAF6 TNF 16191192 318578 Positive_regulation TAF9 TNF 16191192 318579 Positive_regulation TANK ARSA 18411340 1550451 Positive_regulation TANK TNF 16115325 1036148 Positive_regulation TANK TNF 18246321 1644000 Positive_regulation TANK TNF 19918265 609898 Positive_regulation TANK TNF 20484576 1776874 Positive_regulation TANK TNF 21119000 1783905 Positive_regulation TANK TNF 23771139 2089825 Positive_regulation TANK TNF 23771139 2089827 Positive_regulation TANK TNF 23771139 2089829 Positive_regulation TANK TNF 24457959 571468 Positive_regulation TAP1 TNF 7699330 1591710 Positive_regulation TAP1 TNF 7699330 1591711 Positive_regulation TAP1 TNF 7699330 1591713 Positive_regulation TAP1 TNF 9016879 1599989 Positive_regulation TAP2 TNF 9016879 1599988 Positive_regulation TAP2 TNF 9016879 1599990 Positive_regulation TARDBP CAPN8 24369767 809505 Positive_regulation TARDBP CAPN8 25210488 1488751 Positive_regulation TARDBP EPHB2 22879928 2673132 Positive_regulation TARDBP EPHB2 22879928 2673134 Positive_regulation TARDBP EPHB2 23840699 2816153 Positive_regulation TARS TNF 23425968 3134252 Positive_regulation TARS TNF 23425968 3134253 Positive_regulation TARS TNF 23425968 3134254 Positive_regulation TARS TNF 23425968 3134262 Positive_regulation TARS TNF 23425968 3134264 Positive_regulation TAS2R13 FOXO1 24490110 3151481 Positive_regulation TAS2R13 PGC 21076579 1710297 Positive_regulation TAS2R38 CTGF 23750089 163600 Positive_regulation TAS2R38 NPNT 22518348 1692903 Positive_regulation TAS2R38 NPNT 22518348 1692907 Positive_regulation TAT DAPK1 24464042 1968771 Positive_regulation TAT EPHB2 23555914 2775922 Positive_regulation TAT MMP28 24359561 3216090 Positive_regulation TAT MMP7 24359561 3216105 Positive_regulation TAT PLAU 25295247 200728 Positive_regulation TAT TNF 22187158 2070777 Positive_regulation TAT TNF 23190742 1665189 Positive_regulation TAT TNF 23758766 3121888 Positive_regulation TAT TNF 24165011 3123844 Positive_regulation TAT TNF 24911386 2012029 Positive_regulation TAT TNF PMC3837019 3038925 Positive_regulation TAT TNFSF10 18769477 2395884 Positive_regulation TAT TNFSF10 20862322 3048570 Positive_regulation TAZ CTGF 20972459 2136512 Positive_regulation TAZ CTGF 22762204 212955 Positive_regulation TAZ CTGF 25354978 1887234 Positive_regulation TAZ CTGF 25354978 1887235 Positive_regulation TAZ CTGF 25354978 1887242 Positive_regulation TAZ ITGB2 20972459 2136513 Positive_regulation TBC1D15 RAB31 24569479 753045 Positive_regulation TBC1D4 TNF 18443205 705799 Positive_regulation TBCA TNF 11390433 1519459 Positive_regulation TBCC TNF 8627186 1596298 Positive_regulation TBCE FOXO1 19360094 2308746 Positive_regulation TBCE TNF 23133491 816226 Positive_regulation TBCE TNF 23209806 2723121 Positive_regulation TBK1 TLR7 21904615 2550464 Positive_regulation TBK1 TLR7 22723946 2655290 Positive_regulation TBK1 TLR7 24270516 1959377 Positive_regulation TBK1 TLR7 25351958 153493 Positive_regulation TBL1X PGC 23304112 3076117 Positive_regulation TBL1XR1 PGC 23304112 3076119 Positive_regulation TBP TNF 16191192 318584 Positive_regulation TBP TNF 22761878 2659071 Positive_regulation TBX1 FOXA1 24039608 2349851 Positive_regulation TBX10 FOXA1 24039608 2349854 Positive_regulation TBX15 FOXA1 24039608 2349857 Positive_regulation TBX18 FOXA1 24039608 2349860 Positive_regulation TBX19 FOXA1 24039608 2349863 Positive_regulation TBX2 FOXA1 24039608 2349866 Positive_regulation TBX20 FOXA1 24039608 2349869 Positive_regulation TBX21 FOXA1 24039608 2349872 Positive_regulation TBX21 FOXO1 23712431 1572178 Positive_regulation TBX22 FOXA1 24039608 2349875 Positive_regulation TBX22 MMP28 12756268 1527365 Positive_regulation TBX22 MMP7 12756268 1527380 Positive_regulation TBX3 FOXA1 24039608 2349878 Positive_regulation TBX4 FOXA1 24039608 2349881 Positive_regulation TBX5 EPHB2 12177047 1286349 Positive_regulation TBX5 FOXA1 24039608 2349884 Positive_regulation TBX5 PECAM1 12177047 1286361 Positive_regulation TBX6 FOXA1 24039608 2349887 Positive_regulation TCEA1 CAPN8 24430868 1820471 Positive_regulation TCEA1 CCND1 23786849 473334 Positive_regulation TCEA1 CHI3L1 22238378 2071472 Positive_regulation TCEA1 CHI3L1 22238378 2071484 Positive_regulation TCEA1 CHI3L1 22238378 2071485 Positive_regulation TCEA1 CHI3L1 22238378 2071488 Positive_regulation TCEA1 CHI3L1 22238378 2071490 Positive_regulation TCEA1 ELOVL4 21139992 1912419 Positive_regulation TCEA1 ELOVL4 24569140 1637945 Positive_regulation TCEA1 ELOVL4 24569140 1637946 Positive_regulation TCEA1 ELOVL4 24569140 1637952 Positive_regulation TCEA1 ELOVL4 24571530 361213 Positive_regulation TCEA1 EPHB2 23741474 2801182 Positive_regulation TCEA1 EPHB2 23741474 2801183 Positive_regulation TCEA1 EPHB2 24260264 2883553 Positive_regulation TCEA1 EPHB2 24444792 1881653 Positive_regulation TCEA1 EPHB2 24587210 2929062 Positive_regulation TCEA1 FAS 23409096 2753510 Positive_regulation TCEA1 FOXO1 19555482 235794 Positive_regulation TCEA1 GAB3 21217643 768917 Positive_regulation TCEA1 ITGAL 22711877 1568390 Positive_regulation TCEA1 ITGAL 22711877 1568391 Positive_regulation TCEA1 ITGAL 22711877 1568398 Positive_regulation TCEA1 KRT38 23565276 2777721 Positive_regulation TCEA1 MAP2K6 24260264 2883562 Positive_regulation TCEA1 MAP2K6 24444792 1881659 Positive_regulation TCEA1 MAP2K6 24649261 1884436 Positive_regulation TCEA1 MMP28 12975354 1297255 Positive_regulation TCEA1 MMP28 25368556 934406 Positive_regulation TCEA1 MMP7 12975354 1297270 Positive_regulation TCEA1 MMP7 25368556 934421 Positive_regulation TCEA1 MYH3 20948626 846398 Positive_regulation TCEA1 NGFR 20156358 402375 Positive_regulation TCEA1 NR2F1 25610373 872962 Positive_regulation TCEA1 PGC 18974884 2399753 Positive_regulation TCEA1 SARM1 21555464 1386912 Positive_regulation TCEA1 SARM1 21555464 1386918 Positive_regulation TCEA1 SARM1 25221470 939088 Positive_regulation TCEA1 SMN2 25105137 195919 Positive_regulation TCEA1 SRGN 20032306 1772591 Positive_regulation TCEA1 SRGN 20032306 1772617 Positive_regulation TCEA1 TMOD1 20737540 694950 Positive_regulation TCEA1 TMOD1 22013379 1222802 Positive_regulation TCEA1 TMOD1 7798317 1441661 Positive_regulation TCEA1 TNF 20308428 1373846 Positive_regulation TCEA1 TNF 20308428 1373850 Positive_regulation TCEA1 TNF 22391038 1396089 Positive_regulation TCEA1 TNF 22615129 1568234 Positive_regulation TCEA1 TNF 22991685 1082683 Positive_regulation TCEA1 TNF 23789107 169945 Positive_regulation TCEA1 TNF 24205293 2875913 Positive_regulation TCEA1 WNT7A 24167472 931334 Positive_regulation TCF12 AXIN2 23724138 2799412 Positive_regulation TCF12 CCND1 22651859 1648813 Positive_regulation TCF12 CCND1 24979278 2160427 Positive_regulation TCF12 CCND1 24979278 2160428 Positive_regulation TCF12 EDN2 11835691 274304 Positive_regulation TCF12 EPHB2 16973895 2022519 Positive_regulation TCF12 EPHB2 19847302 2429309 Positive_regulation TCF12 EPHB2 20809979 386512 Positive_regulation TCF12 EPHB2 20858281 1859202 Positive_regulation TCF12 EPHB2 21345181 304570 Positive_regulation TCF12 EPHB2 21479245 2511475 Positive_regulation TCF12 EPHB2 21887232 2547989 Positive_regulation TCF12 EPHB2 22242005 2328486 Positive_regulation TCF12 EPHB2 22433113 1675695 Positive_regulation TCF12 EPHB2 22566973 900674 Positive_regulation TCF12 EPHB2 22808094 2664305 Positive_regulation TCF12 EPHB2 23738323 181751 Positive_regulation TCF12 EPHB2 23902294 344723 Positive_regulation TCF12 EPHB2 23936658 1719164 Positive_regulation TCF12 EPHB2 24287743 502434 Positive_regulation TCF12 EPHB2 24482225 1208933 Positive_regulation TCF12 EPHB2 24736215 3223848 Positive_regulation TCF12 EPHB2 25121739 2997289 Positive_regulation TCF12 EPHB2 25302800 3014258 Positive_regulation TCF12 EPHB2 25489576 1235966 Positive_regulation TCF12 EPHB2 PMC4291840 541313 Positive_regulation TCF12 FAS 14979919 458288 Positive_regulation TCF12 FAS 19876397 2429921 Positive_regulation TCF12 FAS 24876678 1759142 Positive_regulation TCF12 FBXO32 19108710 324555 Positive_regulation TCF12 FOXO1 21931180 29743 Positive_regulation TCF12 FOXO1 21980390 2560050 Positive_regulation TCF12 FOXO1 23712431 1572181 Positive_regulation TCF12 FZD4 16602827 2260023 Positive_regulation TCF12 GLP1R 24302978 2887155 Positive_regulation TCF12 KRT38 7500028 1587335 Positive_regulation TCF12 LGALS7B 24515895 492418 Positive_regulation TCF12 MAP2K6 17325210 1337651 Positive_regulation TCF12 MAP2K6 23902294 344729 Positive_regulation TCF12 MAP2K6 PMC4291840 541319 Positive_regulation TCF12 NRARP 20150991 1161066 Positive_regulation TCF12 OSR1 24931004 1681280 Positive_regulation TCF12 PGC 18697814 2035857 Positive_regulation TCF12 PGC 24348511 885259 Positive_regulation TCF12 PLAU 23724131 2799368 Positive_regulation TCF12 STAT4 23285134 2732602 Positive_regulation TCF12 TLR7 20706642 1747646 Positive_regulation TCF12 TLR7 21253574 3050385 Positive_regulation TCF12 TLR7 22028588 1222886 Positive_regulation TCF12 TLR7 22358241 652985 Positive_regulation TCF12 TNF 10389973 414435 Positive_regulation TCF12 TNF 11516343 994109 Positive_regulation TCF12 TNF 12745546 1738427 Positive_regulation TCF12 TNF 15642137 102319 Positive_regulation TCF12 TNF 1689365 1542090 Positive_regulation TCF12 TNF 17076895 997484 Positive_regulation TCF12 TNF 17868448 392086 Positive_regulation TCF12 TNF 18053242 1695751 Positive_regulation TCF12 TNF 19351711 708228 Positive_regulation TCF12 TNF 19712456 1696390 Positive_regulation TCF12 TNF 20011590 2433827 Positive_regulation TCF12 TNF 20086228 712789 Positive_regulation TCF12 TNF 20228825 9630 Positive_regulation TCF12 TNF 20594343 119182 Positive_regulation TCF12 TNF 20680494 1654468 Positive_regulation TCF12 TNF 21437140 1162479 Positive_regulation TCF12 TNF 21857970 2544504 Positive_regulation TCF12 TNF 21857970 2544536 Positive_regulation TCF12 TNF 21987656 1565689 Positive_regulation TCF12 TNF 22768286 2660408 Positive_regulation TCF12 TNF 23509807 180562 Positive_regulation TCF12 TNF 23554905 2773637 Positive_regulation TCF12 TNF 23560231 85908 Positive_regulation TCF12 TNF 23843781 696908 Positive_regulation TCF12 TNF 23934574 96678 Positive_regulation TCF12 TNF 23934574 96689 Positive_regulation TCF12 TNF 24381531 684810 Positive_regulation TCF12 TNF 24381640 825019 Positive_regulation TCF12 TNF 24453421 1756762 Positive_regulation TCF12 TNF 24883060 1074201 Positive_regulation TCF12 TNF 24926361 844230 Positive_regulation TCF12 TNF 25215307 1623189 Positive_regulation TCF12 TNF 8381656 444799 Positive_regulation TCF12 ZFP57 23569325 1571581 Positive_regulation TCF15 AXIN2 23724138 2799413 Positive_regulation TCF15 CCND1 22651859 1648814 Positive_regulation TCF15 CCND1 24979278 2160430 Positive_regulation TCF15 CCND1 24979278 2160431 Positive_regulation TCF15 EDN2 11835691 274307 Positive_regulation TCF15 EPHB2 16973895 2022520 Positive_regulation TCF15 EPHB2 19847302 2429310 Positive_regulation TCF15 EPHB2 20809979 386513 Positive_regulation TCF15 EPHB2 20858281 1859204 Positive_regulation TCF15 EPHB2 21345181 304571 Positive_regulation TCF15 EPHB2 21479245 2511489 Positive_regulation TCF15 EPHB2 21887232 2547990 Positive_regulation TCF15 EPHB2 22242005 2328500 Positive_regulation TCF15 EPHB2 22433113 1675696 Positive_regulation TCF15 EPHB2 22566973 900675 Positive_regulation TCF15 EPHB2 22808094 2664306 Positive_regulation TCF15 EPHB2 23738323 181766 Positive_regulation TCF15 EPHB2 23902294 344731 Positive_regulation TCF15 EPHB2 23936658 1719165 Positive_regulation TCF15 EPHB2 24287743 502437 Positive_regulation TCF15 EPHB2 24482225 1208934 Positive_regulation TCF15 EPHB2 24736215 3223849 Positive_regulation TCF15 EPHB2 25121739 2997290 Positive_regulation TCF15 EPHB2 25302800 3014272 Positive_regulation TCF15 EPHB2 25489576 1235967 Positive_regulation TCF15 EPHB2 PMC4291840 541321 Positive_regulation TCF15 FAS 14979919 458289 Positive_regulation TCF15 FAS 19876397 2429927 Positive_regulation TCF15 FAS 24876678 1759143 Positive_regulation TCF15 FBXO32 19108710 324557 Positive_regulation TCF15 FOXO1 21931180 29747 Positive_regulation TCF15 FOXO1 21980390 2560054 Positive_regulation TCF15 FOXO1 23712431 1572182 Positive_regulation TCF15 FZD4 16602827 2260026 Positive_regulation TCF15 GLP1R 24302978 2887156 Positive_regulation TCF15 KRT38 7500028 1587385 Positive_regulation TCF15 LGALS7B 24515895 492419 Positive_regulation TCF15 MAP2K6 17325210 1337658 Positive_regulation TCF15 MAP2K6 23902294 344737 Positive_regulation TCF15 MAP2K6 PMC4291840 541327 Positive_regulation TCF15 NRARP 20150991 1161067 Positive_regulation TCF15 OSR1 24931004 1681281 Positive_regulation TCF15 PGC 18697814 2035858 Positive_regulation TCF15 PGC 24348511 885261 Positive_regulation TCF15 PLAU 23724131 2799369 Positive_regulation TCF15 STAT4 23285134 2732604 Positive_regulation TCF15 TLR7 20706642 1747656 Positive_regulation TCF15 TLR7 21253574 3050387 Positive_regulation TCF15 TLR7 22028588 1222896 Positive_regulation TCF15 TLR7 22358241 652995 Positive_regulation TCF15 TNF 10389973 414436 Positive_regulation TCF15 TNF 11516343 994110 Positive_regulation TCF15 TNF 12745546 1738428 Positive_regulation TCF15 TNF 15642137 102320 Positive_regulation TCF15 TNF 1689365 1542091 Positive_regulation TCF15 TNF 17076895 997485 Positive_regulation TCF15 TNF 17868448 392087 Positive_regulation TCF15 TNF 18053242 1695752 Positive_regulation TCF15 TNF 19351711 708229 Positive_regulation TCF15 TNF 19712456 1696391 Positive_regulation TCF15 TNF 20011590 2433828 Positive_regulation TCF15 TNF 20086228 712791 Positive_regulation TCF15 TNF 20228825 9631 Positive_regulation TCF15 TNF 20594343 119184 Positive_regulation TCF15 TNF 20680494 1654469 Positive_regulation TCF15 TNF 21437140 1162482 Positive_regulation TCF15 TNF 21857970 2544505 Positive_regulation TCF15 TNF 21857970 2544537 Positive_regulation TCF15 TNF 21987656 1565690 Positive_regulation TCF15 TNF 22768286 2660409 Positive_regulation TCF15 TNF 23509807 180563 Positive_regulation TCF15 TNF 23554905 2773638 Positive_regulation TCF15 TNF 23560231 85913 Positive_regulation TCF15 TNF 23843781 696909 Positive_regulation TCF15 TNF 23934574 96679 Positive_regulation TCF15 TNF 23934574 96690 Positive_regulation TCF15 TNF 24381531 684812 Positive_regulation TCF15 TNF 24381640 825021 Positive_regulation TCF15 TNF 24453421 1756763 Positive_regulation TCF15 TNF 24883060 1074203 Positive_regulation TCF15 TNF 24926361 844231 Positive_regulation TCF15 TNF 25215307 1623192 Positive_regulation TCF15 TNF 8381656 444800 Positive_regulation TCF15 ZFP57 23569325 1571599 Positive_regulation TCF19 AXIN2 23724138 2799414 Positive_regulation TCF19 CCND1 22651859 1648815 Positive_regulation TCF19 CCND1 24979278 2160433 Positive_regulation TCF19 CCND1 24979278 2160434 Positive_regulation TCF19 EDN2 11835691 274310 Positive_regulation TCF19 EPHB2 16973895 2022521 Positive_regulation TCF19 EPHB2 19847302 2429311 Positive_regulation TCF19 EPHB2 20809979 386514 Positive_regulation TCF19 EPHB2 20858281 1859206 Positive_regulation TCF19 EPHB2 21345181 304572 Positive_regulation TCF19 EPHB2 21479245 2511503 Positive_regulation TCF19 EPHB2 21887232 2547991 Positive_regulation TCF19 EPHB2 22242005 2328514 Positive_regulation TCF19 EPHB2 22433113 1675697 Positive_regulation TCF19 EPHB2 22566973 900676 Positive_regulation TCF19 EPHB2 22808094 2664307 Positive_regulation TCF19 EPHB2 23738323 181781 Positive_regulation TCF19 EPHB2 23902294 344739 Positive_regulation TCF19 EPHB2 23936658 1719166 Positive_regulation TCF19 EPHB2 24287743 502440 Positive_regulation TCF19 EPHB2 24482225 1208935 Positive_regulation TCF19 EPHB2 24736215 3223850 Positive_regulation TCF19 EPHB2 25121739 2997291 Positive_regulation TCF19 EPHB2 25302800 3014286 Positive_regulation TCF19 EPHB2 25489576 1235968 Positive_regulation TCF19 EPHB2 PMC4291840 541329 Positive_regulation TCF19 FAS 14979919 458290 Positive_regulation TCF19 FAS 19876397 2429933 Positive_regulation TCF19 FAS 24876678 1759144 Positive_regulation TCF19 FBXO32 19108710 324559 Positive_regulation TCF19 FOXO1 21931180 29751 Positive_regulation TCF19 FOXO1 21980390 2560058 Positive_regulation TCF19 FOXO1 23712431 1572183 Positive_regulation TCF19 FZD4 16602827 2260029 Positive_regulation TCF19 GLP1R 24302978 2887157 Positive_regulation TCF19 KRT38 7500028 1587435 Positive_regulation TCF19 LGALS7B 24515895 492420 Positive_regulation TCF19 MAP2K6 17325210 1337665 Positive_regulation TCF19 MAP2K6 23902294 344745 Positive_regulation TCF19 MAP2K6 PMC4291840 541335 Positive_regulation TCF19 NRARP 20150991 1161068 Positive_regulation TCF19 OSR1 24931004 1681282 Positive_regulation TCF19 PGC 18697814 2035859 Positive_regulation TCF19 PGC 24348511 885263 Positive_regulation TCF19 PLAU 23724131 2799370 Positive_regulation TCF19 STAT4 23285134 2732606 Positive_regulation TCF19 TLR7 20706642 1747666 Positive_regulation TCF19 TLR7 21253574 3050389 Positive_regulation TCF19 TLR7 22028588 1222906 Positive_regulation TCF19 TLR7 22358241 653005 Positive_regulation TCF19 TNF 10389973 414437 Positive_regulation TCF19 TNF 11516343 994111 Positive_regulation TCF19 TNF 12745546 1738429 Positive_regulation TCF19 TNF 15642137 102321 Positive_regulation TCF19 TNF 1689365 1542092 Positive_regulation TCF19 TNF 17076895 997486 Positive_regulation TCF19 TNF 17868448 392088 Positive_regulation TCF19 TNF 18053242 1695753 Positive_regulation TCF19 TNF 19351711 708230 Positive_regulation TCF19 TNF 19712456 1696392 Positive_regulation TCF19 TNF 20011590 2433829 Positive_regulation TCF19 TNF 20086228 712793 Positive_regulation TCF19 TNF 20228825 9632 Positive_regulation TCF19 TNF 20594343 119186 Positive_regulation TCF19 TNF 20680494 1654470 Positive_regulation TCF19 TNF 21437140 1162485 Positive_regulation TCF19 TNF 21857970 2544506 Positive_regulation TCF19 TNF 21857970 2544538 Positive_regulation TCF19 TNF 21987656 1565691 Positive_regulation TCF19 TNF 22768286 2660410 Positive_regulation TCF19 TNF 23509807 180564 Positive_regulation TCF19 TNF 23554905 2773639 Positive_regulation TCF19 TNF 23560231 85918 Positive_regulation TCF19 TNF 23843781 696910 Positive_regulation TCF19 TNF 23934574 96680 Positive_regulation TCF19 TNF 23934574 96691 Positive_regulation TCF19 TNF 24381531 684814 Positive_regulation TCF19 TNF 24381640 825023 Positive_regulation TCF19 TNF 24453421 1756764 Positive_regulation TCF19 TNF 24883060 1074205 Positive_regulation TCF19 TNF 24926361 844232 Positive_regulation TCF19 TNF 25215307 1623195 Positive_regulation TCF19 TNF 8381656 444801 Positive_regulation TCF19 ZFP57 23569325 1571617 Positive_regulation TCF20 AXIN2 23724138 2799415 Positive_regulation TCF20 CCND1 22651859 1648816 Positive_regulation TCF20 CCND1 24979278 2160436 Positive_regulation TCF20 CCND1 24979278 2160437 Positive_regulation TCF20 EDN2 11835691 274313 Positive_regulation TCF20 EPHB2 16973895 2022522 Positive_regulation TCF20 EPHB2 19847302 2429312 Positive_regulation TCF20 EPHB2 20809979 386515 Positive_regulation TCF20 EPHB2 20858281 1859208 Positive_regulation TCF20 EPHB2 21345181 304573 Positive_regulation TCF20 EPHB2 21479245 2511517 Positive_regulation TCF20 EPHB2 21887232 2547992 Positive_regulation TCF20 EPHB2 22242005 2328528 Positive_regulation TCF20 EPHB2 22433113 1675698 Positive_regulation TCF20 EPHB2 22566973 900677 Positive_regulation TCF20 EPHB2 22808094 2664308 Positive_regulation TCF20 EPHB2 23738323 181796 Positive_regulation TCF20 EPHB2 23902294 344747 Positive_regulation TCF20 EPHB2 23936658 1719167 Positive_regulation TCF20 EPHB2 24287743 502443 Positive_regulation TCF20 EPHB2 24482225 1208936 Positive_regulation TCF20 EPHB2 24736215 3223851 Positive_regulation TCF20 EPHB2 25121739 2997292 Positive_regulation TCF20 EPHB2 25302800 3014300 Positive_regulation TCF20 EPHB2 25489576 1235969 Positive_regulation TCF20 EPHB2 PMC4291840 541337 Positive_regulation TCF20 FAS 14979919 458291 Positive_regulation TCF20 FAS 19876397 2429939 Positive_regulation TCF20 FAS 24876678 1759145 Positive_regulation TCF20 FBXO32 19108710 324561 Positive_regulation TCF20 FOXO1 21931180 29755 Positive_regulation TCF20 FOXO1 21980390 2560062 Positive_regulation TCF20 FOXO1 23712431 1572184 Positive_regulation TCF20 FZD4 16602827 2260032 Positive_regulation TCF20 GLP1R 24302978 2887158 Positive_regulation TCF20 KRT38 7500028 1587485 Positive_regulation TCF20 LGALS7B 24515895 492421 Positive_regulation TCF20 MAP2K6 17325210 1337672 Positive_regulation TCF20 MAP2K6 23902294 344753 Positive_regulation TCF20 MAP2K6 PMC4291840 541343 Positive_regulation TCF20 NRARP 20150991 1161069 Positive_regulation TCF20 OSR1 24931004 1681283 Positive_regulation TCF20 PGC 18697814 2035860 Positive_regulation TCF20 PGC 24348511 885265 Positive_regulation TCF20 PLAU 23724131 2799371 Positive_regulation TCF20 STAT4 23285134 2732608 Positive_regulation TCF20 TLR7 20706642 1747676 Positive_regulation TCF20 TLR7 21253574 3050391 Positive_regulation TCF20 TLR7 22028588 1222916 Positive_regulation TCF20 TLR7 22358241 653015 Positive_regulation TCF20 TNF 10389973 414438 Positive_regulation TCF20 TNF 11516343 994112 Positive_regulation TCF20 TNF 12745546 1738430 Positive_regulation TCF20 TNF 15642137 102322 Positive_regulation TCF20 TNF 1689365 1542093 Positive_regulation TCF20 TNF 17076895 997487 Positive_regulation TCF20 TNF 17868448 392089 Positive_regulation TCF20 TNF 18053242 1695754 Positive_regulation TCF20 TNF 19351711 708231 Positive_regulation TCF20 TNF 19712456 1696393 Positive_regulation TCF20 TNF 20011590 2433830 Positive_regulation TCF20 TNF 20086228 712795 Positive_regulation TCF20 TNF 20228825 9633 Positive_regulation TCF20 TNF 20594343 119188 Positive_regulation TCF20 TNF 20680494 1654471 Positive_regulation TCF20 TNF 21437140 1162488 Positive_regulation TCF20 TNF 21857970 2544507 Positive_regulation TCF20 TNF 21857970 2544539 Positive_regulation TCF20 TNF 21987656 1565692 Positive_regulation TCF20 TNF 22768286 2660411 Positive_regulation TCF20 TNF 23509807 180565 Positive_regulation TCF20 TNF 23554905 2773640 Positive_regulation TCF20 TNF 23560231 85923 Positive_regulation TCF20 TNF 23843781 696911 Positive_regulation TCF20 TNF 23934574 96681 Positive_regulation TCF20 TNF 23934574 96692 Positive_regulation TCF20 TNF 24381531 684816 Positive_regulation TCF20 TNF 24381640 825025 Positive_regulation TCF20 TNF 24453421 1756765 Positive_regulation TCF20 TNF 24883060 1074207 Positive_regulation TCF20 TNF 24926361 844233 Positive_regulation TCF20 TNF 25215307 1623198 Positive_regulation TCF20 TNF 8381656 444802 Positive_regulation TCF20 ZFP57 23569325 1571635 Positive_regulation TCF21 AXIN2 23724138 2799416 Positive_regulation TCF21 CCND1 22651859 1648817 Positive_regulation TCF21 CCND1 24979278 2160439 Positive_regulation TCF21 CCND1 24979278 2160440 Positive_regulation TCF21 EDN2 11835691 274316 Positive_regulation TCF21 EPHB2 16973895 2022523 Positive_regulation TCF21 EPHB2 19847302 2429313 Positive_regulation TCF21 EPHB2 20809979 386516 Positive_regulation TCF21 EPHB2 20858281 1859210 Positive_regulation TCF21 EPHB2 21345181 304574 Positive_regulation TCF21 EPHB2 21479245 2511531 Positive_regulation TCF21 EPHB2 21887232 2547993 Positive_regulation TCF21 EPHB2 22242005 2328542 Positive_regulation TCF21 EPHB2 22433113 1675699 Positive_regulation TCF21 EPHB2 22566973 900678 Positive_regulation TCF21 EPHB2 22808094 2664309 Positive_regulation TCF21 EPHB2 23738323 181811 Positive_regulation TCF21 EPHB2 23902294 344755 Positive_regulation TCF21 EPHB2 23936658 1719168 Positive_regulation TCF21 EPHB2 24287743 502446 Positive_regulation TCF21 EPHB2 24482225 1208937 Positive_regulation TCF21 EPHB2 24736215 3223852 Positive_regulation TCF21 EPHB2 25121739 2997293 Positive_regulation TCF21 EPHB2 25302800 3014314 Positive_regulation TCF21 EPHB2 25489576 1235970 Positive_regulation TCF21 EPHB2 PMC4291840 541345 Positive_regulation TCF21 FAS 14979919 458292 Positive_regulation TCF21 FAS 19876397 2429945 Positive_regulation TCF21 FAS 24876678 1759146 Positive_regulation TCF21 FBXO32 19108710 324563 Positive_regulation TCF21 FOXO1 21931180 29759 Positive_regulation TCF21 FOXO1 21980390 2560066 Positive_regulation TCF21 FOXO1 23712431 1572185 Positive_regulation TCF21 FZD4 16602827 2260035 Positive_regulation TCF21 GLP1R 24302978 2887159 Positive_regulation TCF21 KRT38 7500028 1587535 Positive_regulation TCF21 LGALS7B 24515895 492422 Positive_regulation TCF21 MAP2K6 17325210 1337679 Positive_regulation TCF21 MAP2K6 23902294 344761 Positive_regulation TCF21 MAP2K6 PMC4291840 541351 Positive_regulation TCF21 NRARP 20150991 1161070 Positive_regulation TCF21 OSR1 24931004 1681284 Positive_regulation TCF21 PGC 18697814 2035861 Positive_regulation TCF21 PGC 24348511 885267 Positive_regulation TCF21 PLAU 23724131 2799372 Positive_regulation TCF21 STAT4 23285134 2732610 Positive_regulation TCF21 TLR7 20706642 1747686 Positive_regulation TCF21 TLR7 21253574 3050393 Positive_regulation TCF21 TLR7 22028588 1222926 Positive_regulation TCF21 TLR7 22358241 653025 Positive_regulation TCF21 TNF 10389973 414439 Positive_regulation TCF21 TNF 11516343 994113 Positive_regulation TCF21 TNF 12745546 1738431 Positive_regulation TCF21 TNF 15642137 102323 Positive_regulation TCF21 TNF 1689365 1542094 Positive_regulation TCF21 TNF 17076895 997488 Positive_regulation TCF21 TNF 17868448 392090 Positive_regulation TCF21 TNF 18053242 1695755 Positive_regulation TCF21 TNF 19351711 708232 Positive_regulation TCF21 TNF 19712456 1696394 Positive_regulation TCF21 TNF 20011590 2433831 Positive_regulation TCF21 TNF 20086228 712797 Positive_regulation TCF21 TNF 20228825 9634 Positive_regulation TCF21 TNF 20594343 119190 Positive_regulation TCF21 TNF 20680494 1654472 Positive_regulation TCF21 TNF 21437140 1162491 Positive_regulation TCF21 TNF 21857970 2544508 Positive_regulation TCF21 TNF 21857970 2544540 Positive_regulation TCF21 TNF 21987656 1565693 Positive_regulation TCF21 TNF 22768286 2660412 Positive_regulation TCF21 TNF 23509807 180566 Positive_regulation TCF21 TNF 23554905 2773641 Positive_regulation TCF21 TNF 23560231 85928 Positive_regulation TCF21 TNF 23843781 696912 Positive_regulation TCF21 TNF 23934574 96682 Positive_regulation TCF21 TNF 23934574 96693 Positive_regulation TCF21 TNF 24381531 684818 Positive_regulation TCF21 TNF 24381640 825027 Positive_regulation TCF21 TNF 24453421 1756766 Positive_regulation TCF21 TNF 24883060 1074209 Positive_regulation TCF21 TNF 24926361 844234 Positive_regulation TCF21 TNF 25215307 1623201 Positive_regulation TCF21 TNF 8381656 444803 Positive_regulation TCF21 ZFP57 23569325 1571653 Positive_regulation TCF23 AXIN2 23724138 2799420 Positive_regulation TCF23 CCND1 22651859 1648821 Positive_regulation TCF23 CCND1 24979278 2160475 Positive_regulation TCF23 CCND1 24979278 2160476 Positive_regulation TCF23 EDN2 11835691 274329 Positive_regulation TCF23 EPHB2 16973895 2022527 Positive_regulation TCF23 EPHB2 19847302 2429317 Positive_regulation TCF23 EPHB2 20809979 386520 Positive_regulation TCF23 EPHB2 20858281 1859218 Positive_regulation TCF23 EPHB2 21345181 304578 Positive_regulation TCF23 EPHB2 21479245 2511587 Positive_regulation TCF23 EPHB2 21887232 2547997 Positive_regulation TCF23 EPHB2 22242005 2328598 Positive_regulation TCF23 EPHB2 22433113 1675703 Positive_regulation TCF23 EPHB2 22566973 900682 Positive_regulation TCF23 EPHB2 22808094 2664313 Positive_regulation TCF23 EPHB2 23738323 181871 Positive_regulation TCF23 EPHB2 23902294 344787 Positive_regulation TCF23 EPHB2 23936658 1719172 Positive_regulation TCF23 EPHB2 24287743 502458 Positive_regulation TCF23 EPHB2 24482225 1208941 Positive_regulation TCF23 EPHB2 24736215 3223856 Positive_regulation TCF23 EPHB2 25121739 2997297 Positive_regulation TCF23 EPHB2 25302800 3014383 Positive_regulation TCF23 EPHB2 25489576 1235974 Positive_regulation TCF23 EPHB2 PMC4291840 541377 Positive_regulation TCF23 FAS 14979919 458307 Positive_regulation TCF23 FAS 19876397 2429979 Positive_regulation TCF23 FAS 24876678 1759150 Positive_regulation TCF23 FBXO32 19108710 324593 Positive_regulation TCF23 FOXO1 21931180 29775 Positive_regulation TCF23 FOXO1 21980390 2560082 Positive_regulation TCF23 FOXO1 23712431 1572189 Positive_regulation TCF23 FZD4 16602827 2260063 Positive_regulation TCF23 GLP1R 24302978 2887163 Positive_regulation TCF23 KRT38 7500028 1587747 Positive_regulation TCF23 LGALS7B 24515895 492426 Positive_regulation TCF23 MAP2K6 17325210 1337707 Positive_regulation TCF23 MAP2K6 23902294 344793 Positive_regulation TCF23 MAP2K6 PMC4291840 541383 Positive_regulation TCF23 NRARP 20150991 1161074 Positive_regulation TCF23 OSR1 24931004 1681293 Positive_regulation TCF23 PGC 18697814 2035865 Positive_regulation TCF23 PGC 24348511 885275 Positive_regulation TCF23 PLAU 23724131 2799376 Positive_regulation TCF23 STAT4 23285134 2732618 Positive_regulation TCF23 TLR7 20706642 1747726 Positive_regulation TCF23 TLR7 21253574 3050402 Positive_regulation TCF23 TLR7 22028588 1222966 Positive_regulation TCF23 TLR7 22358241 653065 Positive_regulation TCF23 TNF 10389973 414443 Positive_regulation TCF23 TNF 11516343 994128 Positive_regulation TCF23 TNF 12745546 1738435 Positive_regulation TCF23 TNF 15642137 102327 Positive_regulation TCF23 TNF 1689365 1542098 Positive_regulation TCF23 TNF 17076895 997492 Positive_regulation TCF23 TNF 17868448 392095 Positive_regulation TCF23 TNF 18053242 1695759 Positive_regulation TCF23 TNF 19351711 708248 Positive_regulation TCF23 TNF 19712456 1696399 Positive_regulation TCF23 TNF 20011590 2433835 Positive_regulation TCF23 TNF 20086228 712805 Positive_regulation TCF23 TNF 20228825 9638 Positive_regulation TCF23 TNF 20594343 119199 Positive_regulation TCF23 TNF 20680494 1654487 Positive_regulation TCF23 TNF 21437140 1162503 Positive_regulation TCF23 TNF 21857970 2544512 Positive_regulation TCF23 TNF 21857970 2544544 Positive_regulation TCF23 TNF 21987656 1565698 Positive_regulation TCF23 TNF 22768286 2660416 Positive_regulation TCF23 TNF 23509807 180581 Positive_regulation TCF23 TNF 23554905 2773645 Positive_regulation TCF23 TNF 23560231 85948 Positive_regulation TCF23 TNF 23843781 696927 Positive_regulation TCF23 TNF 23934574 96686 Positive_regulation TCF23 TNF 23934574 96697 Positive_regulation TCF23 TNF 24381531 684826 Positive_regulation TCF23 TNF 24381640 825036 Positive_regulation TCF23 TNF 24453421 1756770 Positive_regulation TCF23 TNF 24883060 1074231 Positive_regulation TCF23 TNF 24926361 844298 Positive_regulation TCF23 TNF 25215307 1623227 Positive_regulation TCF23 TNF 8381656 444807 Positive_regulation TCF23 ZFP57 23569325 1571725 Positive_regulation TCF24 AXIN2 23724138 2799422 Positive_regulation TCF24 CCND1 22651859 1648823 Positive_regulation TCF24 CCND1 24979278 2160481 Positive_regulation TCF24 CCND1 24979278 2160482 Positive_regulation TCF24 EDN2 11835691 274335 Positive_regulation TCF24 EPHB2 16973895 2022529 Positive_regulation TCF24 EPHB2 19847302 2429319 Positive_regulation TCF24 EPHB2 20809979 386522 Positive_regulation TCF24 EPHB2 20858281 1859222 Positive_regulation TCF24 EPHB2 21345181 304580 Positive_regulation TCF24 EPHB2 21479245 2511615 Positive_regulation TCF24 EPHB2 21887232 2547999 Positive_regulation TCF24 EPHB2 22242005 2328626 Positive_regulation TCF24 EPHB2 22433113 1675705 Positive_regulation TCF24 EPHB2 22566973 900684 Positive_regulation TCF24 EPHB2 22808094 2664315 Positive_regulation TCF24 EPHB2 23738323 181903 Positive_regulation TCF24 EPHB2 23902294 344803 Positive_regulation TCF24 EPHB2 23936658 1719174 Positive_regulation TCF24 EPHB2 24287743 502464 Positive_regulation TCF24 EPHB2 24482225 1208954 Positive_regulation TCF24 EPHB2 24736215 3223858 Positive_regulation TCF24 EPHB2 25121739 2997301 Positive_regulation TCF24 EPHB2 25302800 3014441 Positive_regulation TCF24 EPHB2 25489576 1235976 Positive_regulation TCF24 EPHB2 PMC4291840 541393 Positive_regulation TCF24 FAS 14979919 458309 Positive_regulation TCF24 FAS 19876397 2429991 Positive_regulation TCF24 FAS 24876678 1759152 Positive_regulation TCF24 FBXO32 19108710 324597 Positive_regulation TCF24 FOXO1 21931180 29783 Positive_regulation TCF24 FOXO1 21980390 2560101 Positive_regulation TCF24 FOXO1 23712431 1572191 Positive_regulation TCF24 FZD4 16602827 2260069 Positive_regulation TCF24 GLP1R 24302978 2887165 Positive_regulation TCF24 KRT38 7500028 1588051 Positive_regulation TCF24 LGALS7B 24515895 492428 Positive_regulation TCF24 MAP2K6 17325210 1337721 Positive_regulation TCF24 MAP2K6 23902294 344809 Positive_regulation TCF24 MAP2K6 PMC4291840 541399 Positive_regulation TCF24 NRARP 20150991 1161076 Positive_regulation TCF24 OSR1 24931004 1681296 Positive_regulation TCF24 PGC 18697814 2035867 Positive_regulation TCF24 PGC 24348511 885279 Positive_regulation TCF24 PLAU 23724131 2799379 Positive_regulation TCF24 STAT4 23285134 2732622 Positive_regulation TCF24 TLR7 20706642 1747746 Positive_regulation TCF24 TLR7 21253574 3050406 Positive_regulation TCF24 TLR7 22028588 1222986 Positive_regulation TCF24 TLR7 22358241 653085 Positive_regulation TCF24 TNF 10389973 414445 Positive_regulation TCF24 TNF 11516343 994130 Positive_regulation TCF24 TNF 12745546 1738437 Positive_regulation TCF24 TNF 15642137 102329 Positive_regulation TCF24 TNF 1689365 1542100 Positive_regulation TCF24 TNF 17076895 997494 Positive_regulation TCF24 TNF 17868448 392097 Positive_regulation TCF24 TNF 18053242 1695761 Positive_regulation TCF24 TNF 19351711 708250 Positive_regulation TCF24 TNF 19712456 1696401 Positive_regulation TCF24 TNF 20011590 2433837 Positive_regulation TCF24 TNF 20086228 712812 Positive_regulation TCF24 TNF 20228825 9640 Positive_regulation TCF24 TNF 20594343 119203 Positive_regulation TCF24 TNF 20680494 1654489 Positive_regulation TCF24 TNF 21437140 1162509 Positive_regulation TCF24 TNF 21857970 2544514 Positive_regulation TCF24 TNF 21857970 2544546 Positive_regulation TCF24 TNF 21987656 1565700 Positive_regulation TCF24 TNF 22768286 2660419 Positive_regulation TCF24 TNF 23509807 180583 Positive_regulation TCF24 TNF 23554905 2773647 Positive_regulation TCF24 TNF 23560231 85958 Positive_regulation TCF24 TNF 23843781 696929 Positive_regulation TCF24 TNF 23934574 96688 Positive_regulation TCF24 TNF 23934574 96699 Positive_regulation TCF24 TNF 24381531 684830 Positive_regulation TCF24 TNF 24381640 825040 Positive_regulation TCF24 TNF 24453421 1756772 Positive_regulation TCF24 TNF 24883060 1074235 Positive_regulation TCF24 TNF 24926361 844300 Positive_regulation TCF24 TNF 25215307 1623245 Positive_regulation TCF24 TNF 8381656 444809 Positive_regulation TCF24 ZFP57 23569325 1571761 Positive_regulation TCF25 AXIN2 23724138 2799421 Positive_regulation TCF25 CCND1 22651859 1648822 Positive_regulation TCF25 CCND1 24979278 2160478 Positive_regulation TCF25 CCND1 24979278 2160479 Positive_regulation TCF25 EDN2 11835691 274332 Positive_regulation TCF25 EPHB2 16973895 2022528 Positive_regulation TCF25 EPHB2 19847302 2429318 Positive_regulation TCF25 EPHB2 20809979 386521 Positive_regulation TCF25 EPHB2 20858281 1859220 Positive_regulation TCF25 EPHB2 21345181 304579 Positive_regulation TCF25 EPHB2 21479245 2511601 Positive_regulation TCF25 EPHB2 21887232 2547998 Positive_regulation TCF25 EPHB2 22242005 2328612 Positive_regulation TCF25 EPHB2 22433113 1675704 Positive_regulation TCF25 EPHB2 22566973 900683 Positive_regulation TCF25 EPHB2 22808094 2664314 Positive_regulation TCF25 EPHB2 23738323 181888 Positive_regulation TCF25 EPHB2 23902294 344795 Positive_regulation TCF25 EPHB2 23936658 1719173 Positive_regulation TCF25 EPHB2 24287743 502461 Positive_regulation TCF25 EPHB2 24482225 1208953 Positive_regulation TCF25 EPHB2 24736215 3223857 Positive_regulation TCF25 EPHB2 25121739 2997298 Positive_regulation TCF25 EPHB2 25302800 3014427 Positive_regulation TCF25 EPHB2 25489576 1235975 Positive_regulation TCF25 EPHB2 PMC4291840 541385 Positive_regulation TCF25 FAS 14979919 458308 Positive_regulation TCF25 FAS 19876397 2429985 Positive_regulation TCF25 FAS 24876678 1759151 Positive_regulation TCF25 FBXO32 19108710 324595 Positive_regulation TCF25 FOXO1 21931180 29779 Positive_regulation TCF25 FOXO1 21980390 2560097 Positive_regulation TCF25 FOXO1 23712431 1572190 Positive_regulation TCF25 FZD4 16602827 2260066 Positive_regulation TCF25 GLP1R 24302978 2887164 Positive_regulation TCF25 KRT38 7500028 1587953 Positive_regulation TCF25 LGALS7B 24515895 492427 Positive_regulation TCF25 MAP2K6 17325210 1337714 Positive_regulation TCF25 MAP2K6 23902294 344801 Positive_regulation TCF25 MAP2K6 PMC4291840 541391 Positive_regulation TCF25 NRARP 20150991 1161075 Positive_regulation TCF25 OSR1 24931004 1681295 Positive_regulation TCF25 PGC 18697814 2035866 Positive_regulation TCF25 PGC 24348511 885277 Positive_regulation TCF25 PLAU 23724131 2799378 Positive_regulation TCF25 STAT4 23285134 2732620 Positive_regulation TCF25 TLR7 20706642 1747736 Positive_regulation TCF25 TLR7 21253574 3050404 Positive_regulation TCF25 TLR7 22028588 1222976 Positive_regulation TCF25 TLR7 22358241 653075 Positive_regulation TCF25 TNF 10389973 414444 Positive_regulation TCF25 TNF 11516343 994129 Positive_regulation TCF25 TNF 12745546 1738436 Positive_regulation TCF25 TNF 15642137 102328 Positive_regulation TCF25 TNF 1689365 1542099 Positive_regulation TCF25 TNF 17076895 997493 Positive_regulation TCF25 TNF 17868448 392096 Positive_regulation TCF25 TNF 18053242 1695760 Positive_regulation TCF25 TNF 19351711 708249 Positive_regulation TCF25 TNF 19712456 1696400 Positive_regulation TCF25 TNF 20011590 2433836 Positive_regulation TCF25 TNF 20086228 712810 Positive_regulation TCF25 TNF 20228825 9639 Positive_regulation TCF25 TNF 20594343 119201 Positive_regulation TCF25 TNF 20680494 1654488 Positive_regulation TCF25 TNF 21437140 1162506 Positive_regulation TCF25 TNF 21857970 2544513 Positive_regulation TCF25 TNF 21857970 2544545 Positive_regulation TCF25 TNF 21987656 1565699 Positive_regulation TCF25 TNF 22768286 2660418 Positive_regulation TCF25 TNF 23509807 180582 Positive_regulation TCF25 TNF 23554905 2773646 Positive_regulation TCF25 TNF 23560231 85953 Positive_regulation TCF25 TNF 23843781 696928 Positive_regulation TCF25 TNF 23934574 96687 Positive_regulation TCF25 TNF 23934574 96698 Positive_regulation TCF25 TNF 24381531 684828 Positive_regulation TCF25 TNF 24381640 825038 Positive_regulation TCF25 TNF 24453421 1756771 Positive_regulation TCF25 TNF 24883060 1074233 Positive_regulation TCF25 TNF 24926361 844299 Positive_regulation TCF25 TNF 25215307 1623242 Positive_regulation TCF25 TNF 8381656 444808 Positive_regulation TCF25 ZFP57 23569325 1571743 Positive_regulation TCF3 AXIN2 23724138 2799417 Positive_regulation TCF3 CCND1 22651859 1648818 Positive_regulation TCF3 CCND1 24979278 2160442 Positive_regulation TCF3 CCND1 24979278 2160443 Positive_regulation TCF3 EDN2 11835691 274319 Positive_regulation TCF3 EDN2 9927512 1605150 Positive_regulation TCF3 EPHB2 16973895 2022524 Positive_regulation TCF3 EPHB2 19847302 2429314 Positive_regulation TCF3 EPHB2 20809979 386517 Positive_regulation TCF3 EPHB2 20858281 1859212 Positive_regulation TCF3 EPHB2 21345181 304575 Positive_regulation TCF3 EPHB2 21479245 2511545 Positive_regulation TCF3 EPHB2 21887232 2547994 Positive_regulation TCF3 EPHB2 22037603 1956041 Positive_regulation TCF3 EPHB2 22242005 2328556 Positive_regulation TCF3 EPHB2 22433113 1675700 Positive_regulation TCF3 EPHB2 22566973 900679 Positive_regulation TCF3 EPHB2 22808094 2664310 Positive_regulation TCF3 EPHB2 23738323 181826 Positive_regulation TCF3 EPHB2 23902294 344763 Positive_regulation TCF3 EPHB2 23936658 1719169 Positive_regulation TCF3 EPHB2 24287743 502449 Positive_regulation TCF3 EPHB2 24482225 1208938 Positive_regulation TCF3 EPHB2 24736215 3223853 Positive_regulation TCF3 EPHB2 24765092 912325 Positive_regulation TCF3 EPHB2 25121739 2997294 Positive_regulation TCF3 EPHB2 25302800 3014328 Positive_regulation TCF3 EPHB2 25489576 1235971 Positive_regulation TCF3 EPHB2 PMC4291840 541353 Positive_regulation TCF3 FAS 14979919 458293 Positive_regulation TCF3 FAS 19876397 2429951 Positive_regulation TCF3 FAS 24876678 1759147 Positive_regulation TCF3 FBXO32 19108710 324565 Positive_regulation TCF3 FOXO1 21931180 29763 Positive_regulation TCF3 FOXO1 21980390 2560070 Positive_regulation TCF3 FOXO1 23712431 1572186 Positive_regulation TCF3 FZD4 16602827 2260038 Positive_regulation TCF3 GLP1R 24302978 2887160 Positive_regulation TCF3 KRT38 7500028 1587585 Positive_regulation TCF3 LGALS7B 24515895 492423 Positive_regulation TCF3 MAP2K6 17325210 1337686 Positive_regulation TCF3 MAP2K6 23902294 344769 Positive_regulation TCF3 MAP2K6 PMC4291840 541359 Positive_regulation TCF3 NRARP 20150991 1161071 Positive_regulation TCF3 OSR1 24931004 1681285 Positive_regulation TCF3 PGC 18697814 2035862 Positive_regulation TCF3 PGC 24348511 885269 Positive_regulation TCF3 PLAU 23724131 2799373 Positive_regulation TCF3 STAT4 23285134 2732612 Positive_regulation TCF3 TLR7 20706642 1747696 Positive_regulation TCF3 TLR7 21253574 3050395 Positive_regulation TCF3 TLR7 22028588 1222936 Positive_regulation TCF3 TLR7 22358241 653035 Positive_regulation TCF3 TNF 10389973 414440 Positive_regulation TCF3 TNF 11516343 994114 Positive_regulation TCF3 TNF 12745546 1738432 Positive_regulation TCF3 TNF 15642137 102324 Positive_regulation TCF3 TNF 1689365 1542095 Positive_regulation TCF3 TNF 17076895 997489 Positive_regulation TCF3 TNF 17868448 392091 Positive_regulation TCF3 TNF 18053242 1695756 Positive_regulation TCF3 TNF 19351711 708233 Positive_regulation TCF3 TNF 19712456 1696395 Positive_regulation TCF3 TNF 20011590 2433832 Positive_regulation TCF3 TNF 20086228 712799 Positive_regulation TCF3 TNF 20228825 9635 Positive_regulation TCF3 TNF 20594343 119192 Positive_regulation TCF3 TNF 20680494 1654473 Positive_regulation TCF3 TNF 21437140 1162494 Positive_regulation TCF3 TNF 21857970 2544509 Positive_regulation TCF3 TNF 21857970 2544541 Positive_regulation TCF3 TNF 21987656 1565694 Positive_regulation TCF3 TNF 22768286 2660413 Positive_regulation TCF3 TNF 23509807 180567 Positive_regulation TCF3 TNF 23554905 2773642 Positive_regulation TCF3 TNF 23560231 85933 Positive_regulation TCF3 TNF 23843781 696913 Positive_regulation TCF3 TNF 23934574 96683 Positive_regulation TCF3 TNF 23934574 96694 Positive_regulation TCF3 TNF 24381531 684820 Positive_regulation TCF3 TNF 24381640 825029 Positive_regulation TCF3 TNF 24453421 1756767 Positive_regulation TCF3 TNF 24883060 1074211 Positive_regulation TCF3 TNF 24926361 844235 Positive_regulation TCF3 TNF 25215307 1623204 Positive_regulation TCF3 TNF 8381656 444804 Positive_regulation TCF3 ZFP57 23569325 1571671 Positive_regulation TCF4 AXIN2 23724138 2799418 Positive_regulation TCF4 CCND1 22651859 1648819 Positive_regulation TCF4 CCND1 24979278 2160445 Positive_regulation TCF4 CCND1 24979278 2160446 Positive_regulation TCF4 EDN2 11835691 274322 Positive_regulation TCF4 EPHB2 16973895 2022525 Positive_regulation TCF4 EPHB2 19847302 2429315 Positive_regulation TCF4 EPHB2 20809979 386518 Positive_regulation TCF4 EPHB2 20858281 1859214 Positive_regulation TCF4 EPHB2 21345181 304576 Positive_regulation TCF4 EPHB2 21479245 2511559 Positive_regulation TCF4 EPHB2 21887232 2547995 Positive_regulation TCF4 EPHB2 22242005 2328570 Positive_regulation TCF4 EPHB2 22433113 1675701 Positive_regulation TCF4 EPHB2 22566973 900680 Positive_regulation TCF4 EPHB2 22808094 2664311 Positive_regulation TCF4 EPHB2 23738323 181841 Positive_regulation TCF4 EPHB2 23902294 344771 Positive_regulation TCF4 EPHB2 23936658 1719170 Positive_regulation TCF4 EPHB2 24287743 502452 Positive_regulation TCF4 EPHB2 24482225 1208939 Positive_regulation TCF4 EPHB2 24736215 3223854 Positive_regulation TCF4 EPHB2 25121739 2997295 Positive_regulation TCF4 EPHB2 25302800 3014342 Positive_regulation TCF4 EPHB2 25489576 1235972 Positive_regulation TCF4 EPHB2 PMC4291840 541361 Positive_regulation TCF4 FAS 14979919 458294 Positive_regulation TCF4 FAS 19876397 2429957 Positive_regulation TCF4 FAS 24876678 1759148 Positive_regulation TCF4 FBXO32 19108710 324567 Positive_regulation TCF4 FOXO1 21931180 29767 Positive_regulation TCF4 FOXO1 21980390 2560074 Positive_regulation TCF4 FOXO1 23712431 1572187 Positive_regulation TCF4 FZD4 16602827 2260041 Positive_regulation TCF4 GLP1R 24302978 2887161 Positive_regulation TCF4 KRT38 7500028 1587635 Positive_regulation TCF4 LGALS7B 24515895 492424 Positive_regulation TCF4 MAP2K6 17325210 1337693 Positive_regulation TCF4 MAP2K6 23902294 344777 Positive_regulation TCF4 MAP2K6 PMC4291840 541367 Positive_regulation TCF4 NRARP 20150991 1161072 Positive_regulation TCF4 OSR1 24931004 1681286 Positive_regulation TCF4 PGC 18697814 2035863 Positive_regulation TCF4 PGC 24348511 885271 Positive_regulation TCF4 PLAU 23724131 2799374 Positive_regulation TCF4 STAT4 23285134 2732614 Positive_regulation TCF4 TLR7 20706642 1747706 Positive_regulation TCF4 TLR7 21253574 3050397 Positive_regulation TCF4 TLR7 22028588 1222946 Positive_regulation TCF4 TLR7 22358241 653045 Positive_regulation TCF4 TNF 10389973 414441 Positive_regulation TCF4 TNF 11516343 994115 Positive_regulation TCF4 TNF 12745546 1738433 Positive_regulation TCF4 TNF 15642137 102325 Positive_regulation TCF4 TNF 1689365 1542096 Positive_regulation TCF4 TNF 17076895 997490 Positive_regulation TCF4 TNF 17868448 392092 Positive_regulation TCF4 TNF 18053242 1695757 Positive_regulation TCF4 TNF 19351711 708234 Positive_regulation TCF4 TNF 19712456 1696396 Positive_regulation TCF4 TNF 20011590 2433833 Positive_regulation TCF4 TNF 20086228 712801 Positive_regulation TCF4 TNF 20228825 9636 Positive_regulation TCF4 TNF 20594343 119194 Positive_regulation TCF4 TNF 20680494 1654474 Positive_regulation TCF4 TNF 21437140 1162497 Positive_regulation TCF4 TNF 21857970 2544510 Positive_regulation TCF4 TNF 21857970 2544542 Positive_regulation TCF4 TNF 21987656 1565695 Positive_regulation TCF4 TNF 22768286 2660414 Positive_regulation TCF4 TNF 23509807 180568 Positive_regulation TCF4 TNF 23554905 2773643 Positive_regulation TCF4 TNF 23560231 85938 Positive_regulation TCF4 TNF 23843781 696914 Positive_regulation TCF4 TNF 23934574 96684 Positive_regulation TCF4 TNF 23934574 96695 Positive_regulation TCF4 TNF 24381531 684822 Positive_regulation TCF4 TNF 24381640 825031 Positive_regulation TCF4 TNF 24453421 1756768 Positive_regulation TCF4 TNF 24580841 3169896 Positive_regulation TCF4 TNF 24883060 1074213 Positive_regulation TCF4 TNF 24926361 844236 Positive_regulation TCF4 TNF 25215307 1623207 Positive_regulation TCF4 TNF 8381656 444805 Positive_regulation TCF4 ZFP57 23569325 1571689 Positive_regulation TCF7 AXIN2 23724138 2799419 Positive_regulation TCF7 CCND1 22651859 1648820 Positive_regulation TCF7 CCND1 24979278 2160448 Positive_regulation TCF7 CCND1 24979278 2160449 Positive_regulation TCF7 EDN2 11835691 274325 Positive_regulation TCF7 EPHB2 16973895 2022526 Positive_regulation TCF7 EPHB2 19847302 2429316 Positive_regulation TCF7 EPHB2 20809979 386519 Positive_regulation TCF7 EPHB2 20858281 1859216 Positive_regulation TCF7 EPHB2 21345181 304577 Positive_regulation TCF7 EPHB2 21479245 2511573 Positive_regulation TCF7 EPHB2 21887232 2547996 Positive_regulation TCF7 EPHB2 22242005 2328584 Positive_regulation TCF7 EPHB2 22433113 1675702 Positive_regulation TCF7 EPHB2 22566973 900681 Positive_regulation TCF7 EPHB2 22808094 2664312 Positive_regulation TCF7 EPHB2 23738323 181856 Positive_regulation TCF7 EPHB2 23902294 344779 Positive_regulation TCF7 EPHB2 23936658 1719171 Positive_regulation TCF7 EPHB2 24287743 502455 Positive_regulation TCF7 EPHB2 24482225 1208940 Positive_regulation TCF7 EPHB2 24736215 3223855 Positive_regulation TCF7 EPHB2 25121739 2997296 Positive_regulation TCF7 EPHB2 25302800 3014356 Positive_regulation TCF7 EPHB2 25489576 1235973 Positive_regulation TCF7 EPHB2 PMC4291840 541369 Positive_regulation TCF7 FAS 14979919 458295 Positive_regulation TCF7 FAS 19876397 2429963 Positive_regulation TCF7 FAS 24876678 1759149 Positive_regulation TCF7 FBXO32 19108710 324569 Positive_regulation TCF7 FOXO1 21931180 29771 Positive_regulation TCF7 FOXO1 21980390 2560078 Positive_regulation TCF7 FOXO1 23712431 1572188 Positive_regulation TCF7 FOXO1 23712431 1572203 Positive_regulation TCF7 FZD4 16602827 2260044 Positive_regulation TCF7 GLP1R 24302978 2887162 Positive_regulation TCF7 KRT38 7500028 1587685 Positive_regulation TCF7 LGALS7B 24515895 492425 Positive_regulation TCF7 MAP2K6 17325210 1337700 Positive_regulation TCF7 MAP2K6 23902294 344785 Positive_regulation TCF7 MAP2K6 PMC4291840 541375 Positive_regulation TCF7 NRARP 20150991 1161073 Positive_regulation TCF7 OSR1 24931004 1681287 Positive_regulation TCF7 PGC 18697814 2035864 Positive_regulation TCF7 PGC 24348511 885273 Positive_regulation TCF7 PLAU 23724131 2799375 Positive_regulation TCF7 STAT4 23285134 2732616 Positive_regulation TCF7 TLR7 20706642 1747716 Positive_regulation TCF7 TLR7 21253574 3050399 Positive_regulation TCF7 TLR7 22028588 1222956 Positive_regulation TCF7 TLR7 22358241 653055 Positive_regulation TCF7 TNF 10389973 414442 Positive_regulation TCF7 TNF 11516343 994116 Positive_regulation TCF7 TNF 12745546 1738434 Positive_regulation TCF7 TNF 15642137 102326 Positive_regulation TCF7 TNF 1689365 1542097 Positive_regulation TCF7 TNF 17076895 997491 Positive_regulation TCF7 TNF 17868448 392093 Positive_regulation TCF7 TNF 18053242 1695758 Positive_regulation TCF7 TNF 19351711 708235 Positive_regulation TCF7 TNF 19712456 1696397 Positive_regulation TCF7 TNF 20011590 2433834 Positive_regulation TCF7 TNF 20086228 712803 Positive_regulation TCF7 TNF 20228825 9637 Positive_regulation TCF7 TNF 20594343 119196 Positive_regulation TCF7 TNF 20680494 1654475 Positive_regulation TCF7 TNF 21437140 1162500 Positive_regulation TCF7 TNF 21857970 2544511 Positive_regulation TCF7 TNF 21857970 2544543 Positive_regulation TCF7 TNF 21987656 1565696 Positive_regulation TCF7 TNF 22768286 2660415 Positive_regulation TCF7 TNF 23509807 180569 Positive_regulation TCF7 TNF 23554905 2773644 Positive_regulation TCF7 TNF 23560231 85943 Positive_regulation TCF7 TNF 23843781 696915 Positive_regulation TCF7 TNF 23934574 96685 Positive_regulation TCF7 TNF 23934574 96696 Positive_regulation TCF7 TNF 24381531 684824 Positive_regulation TCF7 TNF 24381640 825033 Positive_regulation TCF7 TNF 24453421 1756769 Positive_regulation TCF7 TNF 24883060 1074215 Positive_regulation TCF7 TNF 24926361 844237 Positive_regulation TCF7 TNF 25215307 1623210 Positive_regulation TCF7 TNF 8381656 444806 Positive_regulation TCF7 WNT7A 22179044 1928048 Positive_regulation TCF7 ZFP57 23569325 1571707 Positive_regulation TCF7L2 AXIN2 20122174 1853303 Positive_regulation TCF7L2 AXIN2 20122174 1853304 Positive_regulation TCHP MAP2K6 23638878 1868152 Positive_regulation TCN1 APCS 20237826 2243936 Positive_regulation TCN1 APCS 8666949 1597687 Positive_regulation TCN1 CASP3 23936501 2831124 Positive_regulation TCN1 CASP8 23936501 2831125 Positive_regulation TCN1 CD27 17060478 1543088 Positive_regulation TCN1 CD4 22750193 1492593 Positive_regulation TCN1 CD70 17060478 1543089 Positive_regulation TCN1 CD79A 21326197 1918177 Positive_regulation TCN1 CD8A 25560237 3037213 Positive_regulation TCN1 CD8B 25560237 3037214 Positive_regulation TCN1 CXCL12 24735601 1667968 Positive_regulation TCN1 CXCL12 24735601 1667974 Positive_regulation TCN1 CXCL12 24735601 1667992 Positive_regulation TCN1 CXCL12 24735601 1667993 Positive_regulation TCN1 CXCL12 24735601 1667996 Positive_regulation TCN1 CXCL12 24735601 1667997 Positive_regulation TCN1 DRG1 24735601 1667975 Positive_regulation TCN1 DRG2 24735601 1667976 Positive_regulation TCN1 FOXP3 23964850 3210563 Positive_regulation TCN1 HNRNPF 18477807 705922 Positive_regulation TCN1 HNRNPF 22750193 1492600 Positive_regulation TCN1 HNRNPH1 18477807 705923 Positive_regulation TCN1 HNRNPH1 22750193 1492601 Positive_regulation TCN1 IL12A 18725520 1551757 Positive_regulation TCN1 IL12A 22829762 3057878 Positive_regulation TCN1 IL12B 18725520 1551758 Positive_regulation TCN1 IL12B 22829762 3057879 Positive_regulation TCN1 IL2RA 23964850 3210562 Positive_regulation TCN1 IL4 7595220 1590905 Positive_regulation TCN1 IL7 24147035 2869540 Positive_regulation TCN1 IL9 20445754 1215207 Positive_regulation TCN1 INS 23171593 1684690 Positive_regulation TCN1 NAALADL1 24147035 2869539 Positive_regulation TCN1 NAALADL1 24147035 2869558 Positive_regulation TCN1 NAALADL1 24147035 2869580 Positive_regulation TCN1 NAALADL1 24147035 2869586 Positive_regulation TCN1 NELFCD 20087354 434420 Positive_regulation TCN1 PARP1 23936501 2831126 Positive_regulation TCN1 PTBP1 18477807 705924 Positive_regulation TCN1 PTBP1 22750193 1492602 Positive_regulation TCN1 PTBP2 18477807 705920 Positive_regulation TCN1 PTBP2 22750193 1492599 Positive_regulation TCN1 TRIM26 20087354 434419 Positive_regulation TCN1 TSLP 18477807 705921 Positive_regulation TDGF1P3 CD14 1708813 1543164 Positive_regulation TDGF1P3 CD14 1708813 1543165 Positive_regulation TDGF1P3 CD14 23983613 1061894 Positive_regulation TDGF1P3 CD14 24904837 865240 Positive_regulation TDGF1P3 LBP 1708813 1543155 Positive_regulation TDGF1P3 LBP 1708813 1543156 Positive_regulation TDGF1P3 LBP 1708813 1543160 Positive_regulation TDGF1P3 LBP 1708813 1543161 Positive_regulation TDGF1P3 LBP 1708813 1543162 Positive_regulation TDGF1P3 LBP 1708813 1543167 Positive_regulation TDGF1P3 SELL 11817675 1738023 Positive_regulation TDGF1P3 TNF 17355628 108152 Positive_regulation TDGF1P3 TNF 1972179 1556147 Positive_regulation TDRD7 TLR7 25566264 921688 Positive_regulation TEAD1 CCND1 23720711 944259 Positive_regulation TEAD1 CTGF 23029054 2694334 Positive_regulation TEAD2 CCND1 23720711 944260 Positive_regulation TEAD2 CTGF 23029054 2694335 Positive_regulation TEAD3 CCND1 23720711 944261 Positive_regulation TEAD3 CTGF 23029054 2694336 Positive_regulation TEAD4 CCND1 23720711 944262 Positive_regulation TEAD4 CTGF 23029054 2694337 Positive_regulation TEC CHI3L1 22238378 2071473 Positive_regulation TEC CHI3L1 22238378 2071474 Positive_regulation TEC CHI3L1 22238378 2071475 Positive_regulation TEC CHI3L1 22238378 2071493 Positive_regulation TEC TNF 23717673 2798734 Positive_regulation TECR CLDN10 24069372 2853144 Positive_regulation TECR TNF 21473788 1658068 Positive_regulation TECR TNF 22553939 391006 Positive_regulation TECR TNF 23924897 1817692 Positive_regulation TECR TNF 23924897 1817702 Positive_regulation TEF S100B 20672023 512966 Positive_regulation TEF S100B 20672023 512968 Positive_regulation TEK ANGPT1 20467564 1672199 Positive_regulation TEK ANGPT1 20467564 1672201 Positive_regulation TEK ANGPT1 21188144 2489437 Positive_regulation TEK ANGPT1 22190963 3172954 Positive_regulation TERF1 PECAM1 10725328 1256524 Positive_regulation TERF2 EPHB2 23758320 151599 Positive_regulation TERF2 PECAM1 10725328 1256525 Positive_regulation TERF2 PECAM1 10725328 1256526 Positive_regulation TERF2 PECAM1 10725328 1256549 Positive_regulation TERF2 TNF 16043520 1536938 Positive_regulation TERF2 TNF 23342266 491906 Positive_regulation TERF2IP EPHB2 23758320 151613 Positive_regulation TERF2IP PECAM1 10725328 1256530 Positive_regulation TERF2IP PECAM1 10725328 1256531 Positive_regulation TERF2IP PECAM1 10725328 1256551 Positive_regulation TERF2IP TNF 16043520 1536940 Positive_regulation TERT JAG1 22351600 778075 Positive_regulation TERT JAG1 22351600 778092 Positive_regulation TERT JAG1 22351600 778100 Positive_regulation TERT JAG1 22351600 778101 Positive_regulation TERT JAG1 22351600 778105 Positive_regulation TERT MAP2K6 23409030 2753281 Positive_regulation TERT TNF 24580841 3169884 Positive_regulation TERT ZFP57 25032857 577367 Positive_regulation TERT ZFP57 25032857 577439 Positive_regulation TET1 PGC 23071665 2703705 Positive_regulation TET2 PGC 24322296 2096629 Positive_regulation TET3 PGC 24322296 2096630 Positive_regulation TF A2M 25057495 195449 Positive_regulation TF AKAP10 19797056 1166876 Positive_regulation TF BMP1 24409331 2906957 Positive_regulation TF BMP10 24409331 2906965 Positive_regulation TF BMP15 24409331 2906958 Positive_regulation TF BMP2 24409331 2906959 Positive_regulation TF BMP3 24409331 2906960 Positive_regulation TF BMP4 24409331 2906961 Positive_regulation TF BMP5 24409331 2906962 Positive_regulation TF BMP6 24409331 2906963 Positive_regulation TF BMP7 24409331 2906964 Positive_regulation TF CCL2 23343383 127688 Positive_regulation TF CLTA 18974847 2399588 Positive_regulation TF CLTA 21965292 1795258 Positive_regulation TF CLTC 18974847 2399589 Positive_regulation TF CLTC 21965292 1795259 Positive_regulation TF CMM 22970315 2688182 Positive_regulation TF EGF 2206960 438011 Positive_regulation TF EHD4 17233914 279488 Positive_regulation TF ETV4 22075993 2069370 Positive_regulation TF ETV4 22075993 2069376 Positive_regulation TF ETV5 22075993 2069377 Positive_regulation TF EXOC4 23690179 1405193 Positive_regulation TF GAL 19317920 1227096 Positive_regulation TF HAMP 24616700 953630 Positive_regulation TF HFE 10698721 789672 Positive_regulation TF IL2 6325575 1585719 Positive_regulation TF IL4 21943054 260954 Positive_regulation TF IL6 18472835 1742145 Positive_regulation TF IL7 21943054 260952 Positive_regulation TF INS 2681516 1577820 Positive_regulation TF ITSN2 23472054 2282181 Positive_regulation TF JUN 20519437 1777327 Positive_regulation TF LTF 24376607 2901403 Positive_regulation TF MLC1 24561067 2008390 Positive_regulation TF MYO5B 18687135 281669 Positive_regulation TF ORM1 2991301 1424921 Positive_regulation TF ORM2 2991301 1424922 Positive_regulation TF PICALM 24618820 2933327 Positive_regulation TF RAB5A 23285084 2732437 Positive_regulation TF RAC1 20824170 2370792 Positive_regulation TF RAC1 23638075 2787476 Positive_regulation TF RAC2 23638075 2787477 Positive_regulation TF RAC3 23638075 2787478 Positive_regulation TF SLPI 1892746 431437 Positive_regulation TF SMAD1 24409331 2906966 Positive_regulation TF SMAD2 24409331 2906967 Positive_regulation TF SMAD3 24409331 2906968 Positive_regulation TF SMAD4 24409331 2906969 Positive_regulation TF SMAD5 24409331 2906970 Positive_regulation TF SMAD6 24409331 2906971 Positive_regulation TF SMAD7 24409331 2906972 Positive_regulation TF SMAD9 24409331 2906973 Positive_regulation TF SRP14 1848865 1352263 Positive_regulation TF SRP19 1848865 1352264 Positive_regulation TF SRP54 1848865 1352265 Positive_regulation TF SRP68 1848865 1352266 Positive_regulation TF SRP72 1848865 1352267 Positive_regulation TF SRP9 1848865 1352268 Positive_regulation TF TCF3 23112860 2711226 Positive_regulation TF TFAP2A 22553349 1802386 Positive_regulation TF TFRC 23285084 2732436 Positive_regulation TF TFRC 9064336 1600279 Positive_regulation TF WNT2 20856801 2474688 Positive_regulation TFAM PGC 20491655 147795 Positive_regulation TFAM PGC 22072942 1091852 Positive_regulation TFAM PGC 22848618 2669825 Positive_regulation TFAM PGC 24058702 2848593 Positive_regulation TFAM PGC 24098634 2858239 Positive_regulation TFAP2A TNF 23785430 2805874 Positive_regulation TFAP2A TP63 22573176 2075259 Positive_regulation TFAP2A TP63 22573176 2075260 Positive_regulation TFCP2L1 PIAS1 20661472 2456712 Positive_regulation TFCP2L1 STAT3 23942233 773286 Positive_regulation TFCP2L1 UBC 20661472 2456711 Positive_regulation TFEB PGC 25061009 3203867 Positive_regulation TFPI ARSA 25045211 1760203 Positive_regulation TFPI ARSA 25045211 1760207 Positive_regulation TFPI TNF 16287511 1654817 Positive_regulation TFPI2 CD24 PMC2756345 496047 Positive_regulation TFPI2 CDH5 20386594 2445939 Positive_regulation TFPI2 EDC3 24339780 3065245 Positive_regulation TFPI2 EDC4 24339780 3065244 Positive_regulation TFPI2 HSP90AA1 18922470 1876984 Positive_regulation TFPI2 KLF6 18053161 370951 Positive_regulation TFPI2 LCT 23703216 2088608 Positive_regulation TFPI2 MAP3K5 16953237 427984 Positive_regulation TFPI2 PLG 23554969 2774139 Positive_regulation TFPI2 PPP3R1 19284597 1891167 Positive_regulation TFPI2 PRDX2 18053161 370952 Positive_regulation TFPI2 THBS1 17696609 3039844 Positive_regulation TFR2 TF 24236640 450700 Positive_regulation TFRC EPHB2 21087211 148178 Positive_regulation TFRC EPHB2 21219631 258390 Positive_regulation TFRC MAP2K6 12906713 312788 Positive_regulation TFRC TF 11514599 1520538 Positive_regulation TFRC TF 23285084 2732438 Positive_regulation TFRC TGM2 22451718 1567873 Positive_regulation TFRC TGM2 22451718 1567881 Positive_regulation TGFA EPHB2 20877637 2475424 Positive_regulation TGFA MAP2K6 20877637 2475430 Positive_regulation TGFB1 CD14 22309608 263407 Positive_regulation TGFB1 CTGF 19152120 1478373 Positive_regulation TGFB1 CTGF 19152120 1478403 Positive_regulation TGFB1 CTGF 25401052 692031 Positive_regulation TGFB1 EPHB2 24957684 2232001 Positive_regulation TGFB1 FOXO1 22281705 547798 Positive_regulation TGFB1 PLAT 9792334 1763749 Positive_regulation TGFB1 PLAU 25295247 200726 Positive_regulation TGFB1 TNF 17485515 1545960 Positive_regulation TGFB1 TNF 24142982 2120368 Positive_regulation TGFB1 TNF 9792334 1763748 Positive_regulation TGFB2 CD14 22309608 263409 Positive_regulation TGFB2 TNF 24039874 2844992 Positive_regulation TGFB3 CD14 22309608 263411 Positive_regulation TGFBR1 CTGF 25397671 3027307 Positive_regulation TGFBR1 STK39 23166821 2719342 Positive_regulation TGFBR1 TNF PMC3301465 660973 Positive_regulation TGFBR2 TNF PMC3301465 660974 Positive_regulation TGFBR3 TNF PMC3301465 660975 Positive_regulation TGM1 FLG 24116231 2865891 Positive_regulation TGM2 ADO 15279680 390111 Positive_regulation TGM2 CA2 21310073 229300 Positive_regulation TGM2 CA2 22333138 394077 Positive_regulation TGM2 CA2 24956083 1606541 Positive_regulation TGM2 CA2 24959868 2983260 Positive_regulation TGM2 CA2 7657697 1438325 Positive_regulation TGM2 CA2 7730416 1440040 Positive_regulation TGM2 CA2 8013419 796759 Positive_regulation TGM2 CD79A 22451718 1567875 Positive_regulation TGM2 CD79A 24130874 2867433 Positive_regulation TGM2 CD79A 24130874 2867439 Positive_regulation TGM2 CFTR 24024153 3093302 Positive_regulation TGM2 CPB2 20421939 3046621 Positive_regulation TGM2 FCAR 22451718 1567869 Positive_regulation TGM2 IL17A 24116291 204387 Positive_regulation TGM2 IL1A 24265865 206051 Positive_regulation TGM2 IL1A 24265865 206052 Positive_regulation TGM2 IL1A 24265865 206065 Positive_regulation TGM2 IL1B 20142997 481452 Positive_regulation TGM2 IL22 24116291 204400 Positive_regulation TGM2 IL4 24116291 204388 Positive_regulation TGM2 IL6 22980517 1154899 Positive_regulation TGM2 LIMK1 23437279 2756364 Positive_regulation TGM2 LIMK1 23437279 2756365 Positive_regulation TGM2 MAP2 23437279 2756358 Positive_regulation TGM2 MAP2K1 23437279 2756359 Positive_regulation TGM2 MSH2 25009701 206368 Positive_regulation TGM2 MSH2 25009701 206393 Positive_regulation TGM2 MSH3 25009701 206369 Positive_regulation TGM2 MSH3 25009701 206394 Positive_regulation TGM2 MSH4 25009701 206370 Positive_regulation TGM2 MSH4 25009701 206395 Positive_regulation TGM2 MSH5 25009701 206371 Positive_regulation TGM2 MSH5 25009701 206396 Positive_regulation TGM2 MSH6 25009701 206372 Positive_regulation TGM2 MSH6 25009701 206397 Positive_regulation TGM2 NOS2 20052409 2436670 Positive_regulation TGM2 OSM 23765377 1680828 Positive_regulation TGM2 OSM 23765377 1680844 Positive_regulation TGM2 OSM 23765377 1680848 Positive_regulation TGM2 OSM 23765377 1680850 Positive_regulation TGM2 OSMR 23765377 1680851 Positive_regulation TGM2 SFTPC 24753817 206236 Positive_regulation TGM2 SLC22A3 22566887 899615 Positive_regulation TGM2 SLC22A3 22655269 940658 Positive_regulation TGM2 SPP1 24265865 206078 Positive_regulation TGM2 TNFRSF11B 24265865 206050 Positive_regulation TGM2 TNFRSF11B 24265865 206079 Positive_regulation TGM2 TXN 24130874 2867434 Positive_regulation TH EPHB2 21808606 933233 Positive_regulation THBD ARSA 20877628 2475401 Positive_regulation THBS1 ADAMTS1 20546609 256260 Positive_regulation THBS1 ADAMTS1 20546609 256264 Positive_regulation THBS1 ADAMTS1 20546609 256268 Positive_regulation THBS1 ADAMTS1 20546609 256271 Positive_regulation THBS1 ADAMTS1 20546609 256272 Positive_regulation THBS1 EPHB2 21453480 855646 Positive_regulation THBS1 MMP28 11980922 1282407 Positive_regulation THBS1 MMP28 11980922 1282408 Positive_regulation THBS1 MMP7 11980922 1282439 Positive_regulation THBS1 MMP7 11980922 1282440 Positive_regulation THBS1 MMP7 11980922 1282555 Positive_regulation THBS1 PLAU 10917542 417305 Positive_regulation THBS1 TFPI2 17696609 3039845 Positive_regulation THBS1 TNF 21855683 83494 Positive_regulation THBS1 TNF 25501558 3033604 Positive_regulation THBS1 TNF 25501558 3033608 Positive_regulation THBS2 MMP28 11980922 1282449 Positive_regulation THBS2 MMP7 11980922 1282464 Positive_regulation THM MAP2K6 10637276 1514181 Positive_regulation THRA TNF 19712471 1625643 Positive_regulation THRAP3 TNF 19712471 1625675 Positive_regulation THRSP TNF 8064229 1593929 Positive_regulation THY1 TNF 23613866 2782597 Positive_regulation THY1 TNF 25345415 3146300 Positive_regulation TIA1 FAS 24682828 2099671 Positive_regulation TIA1 FAS 7544399 1590534 Positive_regulation TIAM1 EPHB2 20824214 2473976 Positive_regulation TIAM1 EPHB2 23208503 2150209 Positive_regulation TIAM1 MAP2K6 23208503 2150215 Positive_regulation TIAM2 EPHB2 20824214 2473977 Positive_regulation TIE1 ANGPT1 11342585 1519392 Positive_regulation TIE1 ANGPT1 16157706 1324019 Positive_regulation TIE1 ANGPT1 16417407 2368751 Positive_regulation TIE1 ANGPT1 17341311 279530 Positive_regulation TIE1 ANGPT1 17341311 279547 Positive_regulation TIE1 ANGPT1 17341311 279548 Positive_regulation TIE1 ANGPT1 17341311 279549 Positive_regulation TIE1 ANGPT1 17341311 279555 Positive_regulation TIE1 ANGPT1 17341311 279561 Positive_regulation TIE1 ANGPT1 17717633 493677 Positive_regulation TIE1 ANGPT1 18593464 111003 Positive_regulation TIE1 ANGPT1 18835934 707032 Positive_regulation TIE1 ANGPT1 19435476 659199 Positive_regulation TIE1 ANGPT1 19435476 659220 Positive_regulation TIE1 ANGPT1 19451274 1366052 Positive_regulation TIE1 ANGPT1 19451274 1366053 Positive_regulation TIE1 ANGPT1 19451274 1366065 Positive_regulation TIE1 ANGPT1 19451274 1366072 Positive_regulation TIE1 ANGPT1 19451274 1366073 Positive_regulation TIE1 ANGPT1 19495422 2418145 Positive_regulation TIE1 ANGPT1 19821965 254313 Positive_regulation TIE1 ANGPT1 19889237 326907 Positive_regulation TIE1 ANGPT1 19922791 613205 Positive_regulation TIE1 ANGPT1 20011036 2433037 Positive_regulation TIE1 ANGPT1 20369064 1672042 Positive_regulation TIE1 ANGPT1 20467564 1672200 Positive_regulation TIE1 ANGPT1 20467564 1672202 Positive_regulation TIE1 ANGPT1 20616959 2120644 Positive_regulation TIE1 ANGPT1 20687922 855078 Positive_regulation TIE1 ANGPT1 20805979 2471628 Positive_regulation TIE1 ANGPT1 21113176 12114 Positive_regulation TIE1 ANGPT1 21113176 12118 Positive_regulation TIE1 ANGPT1 21113176 12119 Positive_regulation TIE1 ANGPT1 21113176 12124 Positive_regulation TIE1 ANGPT1 21113176 12125 Positive_regulation TIE1 ANGPT1 21179479 2488312 Positive_regulation TIE1 ANGPT1 21270241 717368 Positive_regulation TIE1 ANGPT1 21378411 2175493 Positive_regulation TIE1 ANGPT1 21378411 2175494 Positive_regulation TIE1 ANGPT1 21378411 2175495 Positive_regulation TIE1 ANGPT1 21378411 2175502 Positive_regulation TIE1 ANGPT1 21439064 1504935 Positive_regulation TIE1 ANGPT1 21599948 332892 Positive_regulation TIE1 ANGPT1 21603628 2523649 Positive_regulation TIE1 ANGPT1 21609465 1616484 Positive_regulation TIE1 ANGPT1 21699724 508502 Positive_regulation TIE1 ANGPT1 21779348 2536799 Positive_regulation TIE1 ANGPT1 21858121 2546410 Positive_regulation TIE1 ANGPT1 22040774 660082 Positive_regulation TIE1 ANGPT1 22087289 2571292 Positive_regulation TIE1 ANGPT1 22125555 1709952 Positive_regulation TIE1 ANGPT1 22187650 1145423 Positive_regulation TIE1 ANGPT1 22235284 2585766 Positive_regulation TIE1 ANGPT1 22343031 1651748 Positive_regulation TIE1 ANGPT1 22343031 1651751 Positive_regulation TIE1 ANGPT1 22343031 1651752 Positive_regulation TIE1 ANGPT1 22343031 1651754 Positive_regulation TIE1 ANGPT1 22448202 3190568 Positive_regulation TIE1 ANGPT1 22454630 832613 Positive_regulation TIE1 ANGPT1 22454630 832647 Positive_regulation TIE1 ANGPT1 22454630 832650 Positive_regulation TIE1 ANGPT1 22454630 832653 Positive_regulation TIE1 ANGPT1 22454630 832654 Positive_regulation TIE1 ANGPT1 22454630 832658 Positive_regulation TIE1 ANGPT1 22539968 2622655 Positive_regulation TIE1 ANGPT1 22566854 898985 Positive_regulation TIE1 ANGPT1 22611498 1145674 Positive_regulation TIE1 ANGPT1 22792187 2661163 Positive_regulation TIE1 ANGPT1 22792187 2661193 Positive_regulation TIE1 ANGPT1 22864384 1727458 Positive_regulation TIE1 ANGPT1 23028407 2219802 Positive_regulation TIE1 ANGPT1 23049737 2699237 Positive_regulation TIE1 ANGPT1 23092791 1620004 Positive_regulation TIE1 ANGPT1 23131162 653805 Positive_regulation TIE1 ANGPT1 23131162 653810 Positive_regulation TIE1 ANGPT1 23131162 653814 Positive_regulation TIE1 ANGPT1 23383853 1728281 Positive_regulation TIE1 ANGPT1 23383853 1728283 Positive_regulation TIE1 ANGPT1 23405099 2751800 Positive_regulation TIE1 ANGPT1 23469160 2762523 Positive_regulation TIE1 ANGPT1 23616286 780641 Positive_regulation TIE1 ANGPT1 23653322 780688 Positive_regulation TIE1 ANGPT1 23799018 2806684 Positive_regulation TIE1 ANGPT1 24013716 2842135 Positive_regulation TIE1 ANGPT1 24156015 492075 Positive_regulation TIE1 ANGPT1 24204851 2874437 Positive_regulation TIE1 ANGPT1 24270910 453557 Positive_regulation TIE1 ANGPT1 24278186 2885609 Positive_regulation TIE1 ANGPT1 24278675 3150021 Positive_regulation TIE1 ANGPT1 24347761 1047892 Positive_regulation TIE1 ANGPT1 24459518 746240 Positive_regulation TIE1 ANGPT1 24459518 746256 Positive_regulation TIE1 ANGPT1 24479731 1618678 Positive_regulation TIE1 ANGPT1 24479731 1618680 Positive_regulation TIE1 ANGPT1 24555007 1693204 Positive_regulation TIE1 ANGPT1 24586553 2925453 Positive_regulation TIE1 ANGPT1 24611021 731587 Positive_regulation TIE1 ANGPT1 24658178 2937708 Positive_regulation TIE1 ANGPT1 24658178 2937710 Positive_regulation TIE1 ANGPT1 24693464 1049484 Positive_regulation TIE1 ANGPT1 24977132 861523 Positive_regulation TIE1 ANGPT1 25185000 1764735 Positive_regulation TIE1 ANGPT1 25185000 1764740 Positive_regulation TIE1 ANGPT1 25279852 3012246 Positive_regulation TIE1 ANGPT1 25364263 2123666 Positive_regulation TIE1 ANGPT1 25364263 2123669 Positive_regulation TIE1 ANGPT1 25364710 861544 Positive_regulation TIE1 ANGPT1 25371820 1690133 Positive_regulation TIE1 ANGPT1 25371820 1690135 Positive_regulation TIE1 ANGPT1 25549350 3036836 Positive_regulation TIE1 FOXO1 20805979 2471627 Positive_regulation TIE1 PECAM1 25051267 2287472 Positive_regulation TIE1 TNF 15535839 101935 Positive_regulation TIE1 TNF 16803639 106169 Positive_regulation TIE1 TNF 19435476 659198 Positive_regulation TIMP1 EPHB2 22327365 1928206 Positive_regulation TIMP1 EPHB2 22818222 1664478 Positive_regulation TIMP1 EPHB2 23457635 2759331 Positive_regulation TIMP1 EPHB2 24349206 2897070 Positive_regulation TIMP1 IL1B 24618842 2933381 Positive_regulation TIMP1 MMP28 21631912 1658465 Positive_regulation TIMP1 MMP28 22230683 398442 Positive_regulation TIMP1 MMP28 22590508 2640776 Positive_regulation TIMP1 MMP28 22911824 2677038 Positive_regulation TIMP1 MMP28 23304261 2225360 Positive_regulation TIMP1 MMP28 24681647 1960371 Positive_regulation TIMP1 MMP28 9184186 446363 Positive_regulation TIMP1 MMP7 21631912 1658481 Positive_regulation TIMP1 MMP7 22230683 398457 Positive_regulation TIMP1 MMP7 22590508 2640791 Positive_regulation TIMP1 MMP7 22911824 2677053 Positive_regulation TIMP1 MMP7 23304261 2225375 Positive_regulation TIMP1 MMP7 24681647 1960386 Positive_regulation TIMP1 MMP7 25107295 647569 Positive_regulation TIMP1 MMP7 9184186 446378 Positive_regulation TIMP1 PLAT 25374584 2007207 Positive_regulation TIMP1 PLAU PMC2834060 134529 Positive_regulation TIMP1 STAT4 23555662 2774781 Positive_regulation TIMP1 TLR7 23223421 91279 Positive_regulation TIMP1 TLR7 23223421 91312 Positive_regulation TIMP1 TNF 10408860 414952 Positive_regulation TIMP1 TNF 16106101 1740038 Positive_regulation TIMP1 TNF 16106101 1740039 Positive_regulation TIMP1 TNF 23755201 2801914 Positive_regulation TIMP1 TNF 23755201 2801915 Positive_regulation TIMP1 TNF 23755201 2801921 Positive_regulation TIMP1 TNF 23967215 2834941 Positive_regulation TIMP1 TNF 24289089 131075 Positive_regulation TIMP1 TNF 8976186 1599720 Positive_regulation TIMP1 TNF 8976186 1599725 Positive_regulation TIMP1 TNF PMC2834114 134581 Positive_regulation TIMP2 MMP28 23091646 2705908 Positive_regulation TIMP2 MMP7 23091646 2705923 Positive_regulation TIMP2 TLR7 23223421 91333 Positive_regulation TIMP2 TNF 16106101 1740040 Positive_regulation TIMP2 TNF 16106101 1740041 Positive_regulation TIMP4 CDKN1C 17603917 320446 Positive_regulation TIMP4 MMP28 23678392 1681648 Positive_regulation TIMP4 MMP7 23678392 1681663 Positive_regulation TINF2 PECAM1 10725328 1256527 Positive_regulation TINF2 TNF 23342266 491907 Positive_regulation TJP1 ANGPT1 23894369 2824430 Positive_regulation TJP1 ANGPT1 25078775 2993653 Positive_regulation TJP1 CAPN8 22931549 2233379 Positive_regulation TJP1 CAPN8 22931549 2233380 Positive_regulation TJP1 CAPN8 22931549 2233381 Positive_regulation TJP1 CAPN8 22931549 2233429 Positive_regulation TJP1 EPHB2 24409324 2906897 Positive_regulation TJP1 MAP2K6 24752320 2956538 Positive_regulation TJP1 PLAT 23565108 935257 Positive_regulation TJP1 TNF 20693346 716075 Positive_regulation TJP1 TNF 20808811 2472490 Positive_regulation TJP1 TNF 21853060 2542969 Positive_regulation TJP1 TNF 25200553 1234624 Positive_regulation TJP2 ANGPT1 25078775 2993655 Positive_regulation TJP3 ANGPT1 25078775 2993657 Positive_regulation TLN1 CAPN8 10545505 1252164 Positive_regulation TLN1 CAPN8 10545505 1252165 Positive_regulation TLN1 CAPN8 10545505 1252166 Positive_regulation TLN1 CAPN8 10545505 1252334 Positive_regulation TLN1 CAPN8 16247034 1325203 Positive_regulation TLN1 CAPN8 20485565 3046868 Positive_regulation TLN1 CAPN8 21576384 1563810 Positive_regulation TLN1 CAPN8 21576384 1563852 Positive_regulation TLN1 CAPN8 7693714 1439048 Positive_regulation TLN1 CAPN8 PMC2151180 1474747 Positive_regulation TLN1 TNS1 7593197 1437689 Positive_regulation TLN2 CAPN8 10545505 1252206 Positive_regulation TLN2 CAPN8 10545505 1252207 Positive_regulation TLN2 CAPN8 10545505 1252208 Positive_regulation TLN2 CAPN8 10545505 1252348 Positive_regulation TLN2 CAPN8 16247034 1325217 Positive_regulation TLN2 CAPN8 20485565 3046882 Positive_regulation TLN2 CAPN8 21576384 1563824 Positive_regulation TLN2 CAPN8 21576384 1563866 Positive_regulation TLN2 CAPN8 7693714 1439076 Positive_regulation TLN2 CAPN8 PMC2151180 1474761 Positive_regulation TLN2 TNS1 7593197 1437694 Positive_regulation TLR1 CD14 20236452 659496 Positive_regulation TLR1 CD14 21078886 1561462 Positive_regulation TLR1 CD14 21789185 2537946 Positive_regulation TLR1 CD14 PMC3109490 927529 Positive_regulation TLR1 CYP24A1 21124742 2484005 Positive_regulation TLR1 EPHB2 22253793 2587950 Positive_regulation TLR1 EPHB2 22783258 902282 Positive_regulation TLR1 EPHB2 24927726 1684585 Positive_regulation TLR1 IL1B 23936458 2830965 Positive_regulation TLR1 IL1B 24060373 1700519 Positive_regulation TLR1 MAP2K6 23405061 2751682 Positive_regulation TLR1 MMP28 18762577 1355339 Positive_regulation TLR1 MMP28 18762577 1355340 Positive_regulation TLR1 MMP28 18762577 1355341 Positive_regulation TLR1 MMP7 18762577 1355384 Positive_regulation TLR1 MMP7 18762577 1355385 Positive_regulation TLR1 MMP7 18762577 1355386 Positive_regulation TLR1 MUC16 24527027 980756 Positive_regulation TLR1 TLR7 17893200 1547122 Positive_regulation TLR1 TLR7 19636364 2370530 Positive_regulation TLR1 TLR7 19686596 3118099 Positive_regulation TLR1 TNF 18227218 1548800 Positive_regulation TLR1 TNF 19183807 2405075 Positive_regulation TLR1 TNF 19419540 3117773 Positive_regulation TLR1 TNF 21915309 2553166 Positive_regulation TLR1 TNF 23283295 3225592 Positive_regulation TLR1 TNF 23484125 179630 Positive_regulation TLR1 TNF 24058791 1705761 Positive_regulation TLR1 TNF 24976686 1759932 Positive_regulation TLR1 TNF PMC3007769 1702438 Positive_regulation TLR1 TNF PMC3242235 1702516 Positive_regulation TLR1 TNFSF10 25196285 3224128 Positive_regulation TLR10 CD14 20236452 659504 Positive_regulation TLR10 CD14 21078886 1561470 Positive_regulation TLR10 CD14 21789185 2537956 Positive_regulation TLR10 CD14 PMC3109490 927537 Positive_regulation TLR10 CYP24A1 21124742 2484013 Positive_regulation TLR10 EPHB2 22253793 2587976 Positive_regulation TLR10 EPHB2 22783258 902298 Positive_regulation TLR10 EPHB2 24927726 1684601 Positive_regulation TLR10 IL1B 23936458 2830973 Positive_regulation TLR10 IL1B 24060373 1700527 Positive_regulation TLR10 MMP28 18762577 1355867 Positive_regulation TLR10 MMP28 18762577 1355868 Positive_regulation TLR10 MMP28 18762577 1355869 Positive_regulation TLR10 MMP7 18762577 1355912 Positive_regulation TLR10 MMP7 18762577 1355913 Positive_regulation TLR10 MMP7 18762577 1355914 Positive_regulation TLR10 MUC16 24527027 980876 Positive_regulation TLR10 TLR7 19686596 3118126 Positive_regulation TLR10 TNF 18227218 1548850 Positive_regulation TLR10 TNF 19183807 2405103 Positive_regulation TLR10 TNF 19419540 3117791 Positive_regulation TLR10 TNF 21915309 2553194 Positive_regulation TLR10 TNF 23283295 3225608 Positive_regulation TLR10 TNF 23484125 179646 Positive_regulation TLR10 TNF 24058791 1705795 Positive_regulation TLR10 TNF PMC3007769 1702454 Positive_regulation TLR10 TNF PMC3242235 1702542 Positive_regulation TLR10 TNFSF10 25196285 3224146 Positive_regulation TLR2 CD14 15142274 101212 Positive_regulation TLR2 CD14 19594951 734072 Positive_regulation TLR2 CD14 20236452 659495 Positive_regulation TLR2 CD14 20236452 659497 Positive_regulation TLR2 CD14 21078886 1561463 Positive_regulation TLR2 CD14 21633096 1992266 Positive_regulation TLR2 CD14 21789185 2537947 Positive_regulation TLR2 CD14 23338226 1879466 Positive_regulation TLR2 CD14 23382920 2746777 Positive_regulation TLR2 CD14 23382920 2746792 Positive_regulation TLR2 CD14 23472173 2764340 Positive_regulation TLR2 CD14 23942912 742206 Positive_regulation TLR2 CD14 24302927 910050 Positive_regulation TLR2 CD14 24349012 2896584 Positive_regulation TLR2 CD14 24966802 484567 Positive_regulation TLR2 CD14 25161655 913916 Positive_regulation TLR2 CD14 25375272 3070131 Positive_regulation TLR2 CD14 25375272 3070145 Positive_regulation TLR2 CD14 25375272 3070146 Positive_regulation TLR2 CD14 25375272 3070150 Positive_regulation TLR2 CD14 25474158 2373479 Positive_regulation TLR2 CD14 9841923 1604781 Positive_regulation TLR2 CD14 PMC3109490 927530 Positive_regulation TLR2 CYP24A1 21124742 2484006 Positive_regulation TLR2 EDN2 18195069 1548247 Positive_regulation TLR2 EDN2 20525138 34474 Positive_regulation TLR2 EPHB2 21998707 2562065 Positive_regulation TLR2 EPHB2 22253793 2587952 Positive_regulation TLR2 EPHB2 22783258 902284 Positive_regulation TLR2 EPHB2 24927726 1684587 Positive_regulation TLR2 FOXO1 24265696 2884913 Positive_regulation TLR2 FOXO1 24265696 2884920 Positive_regulation TLR2 IL1B 15125785 369371 Positive_regulation TLR2 IL1B 23936458 2830966 Positive_regulation TLR2 IL1B 24060373 1700520 Positive_regulation TLR2 MMP28 18762577 1355405 Positive_regulation TLR2 MMP28 18762577 1355406 Positive_regulation TLR2 MMP28 18762577 1355407 Positive_regulation TLR2 MMP7 18762577 1355450 Positive_regulation TLR2 MMP7 18762577 1355451 Positive_regulation TLR2 MMP7 18762577 1355452 Positive_regulation TLR2 MUC16 24527027 980771 Positive_regulation TLR2 TLR7 17893200 1547124 Positive_regulation TLR2 TLR7 17918201 807158 Positive_regulation TLR2 TLR7 19686596 3118100 Positive_regulation TLR2 TLR7 20098705 2437912 Positive_regulation TLR2 TLR7 22837669 1096329 Positive_regulation TLR2 TLR7 24690917 2947298 Positive_regulation TLR2 TLR7 25002964 651798 Positive_regulation TLR2 TNF 14651749 3095627 Positive_regulation TLR2 TNF 16277694 104788 Positive_regulation TLR2 TNF 18001488 109391 Positive_regulation TLR2 TNF 18227218 1548805 Positive_regulation TLR2 TNF 18360633 3176738 Positive_regulation TLR2 TNF 19183807 2405077 Positive_regulation TLR2 TNF 19419540 3117774 Positive_regulation TLR2 TNF 19519926 113551 Positive_regulation TLR2 TNF 19691558 2232102 Positive_regulation TLR2 TNF 19849823 117525 Positive_regulation TLR2 TNF 19936071 2370599 Positive_regulation TLR2 TNF 19966777 1960918 Positive_regulation TLR2 TNF 20204070 1213880 Positive_regulation TLR2 TNF 20396665 1747440 Positive_regulation TLR2 TNF 20946675 1723261 Positive_regulation TLR2 TNF 20946675 1723331 Positive_regulation TLR2 TNF 21203444 2490379 Positive_regulation TLR2 TNF 21556316 1078201 Positive_regulation TLR2 TNF 21915309 2553167 Positive_regulation TLR2 TNF 21960997 979953 Positive_regulation TLR2 TNF 21960997 980020 Positive_regulation TLR2 TNF 22523644 1680569 Positive_regulation TLR2 TNF 22556042 1050692 Positive_regulation TLR2 TNF 22570745 1024133 Positive_regulation TLR2 TNF 22722245 3217186 Positive_regulation TLR2 TNF 22848393 2668622 Positive_regulation TLR2 TNF 22947075 337393 Positive_regulation TLR2 TNF 23283295 3225594 Positive_regulation TLR2 TNF 23304186 637137 Positive_regulation TLR2 TNF 23484125 179632 Positive_regulation TLR2 TNF 23826189 2810741 Positive_regulation TLR2 TNF 23851335 1024539 Positive_regulation TLR2 TNF 23965413 1618301 Positive_regulation TLR2 TNF 24058791 1705764 Positive_regulation TLR2 TNF 24235843 2122407 Positive_regulation TLR2 TNF 24249711 1158344 Positive_regulation TLR2 TNF 24758719 1483085 Positive_regulation TLR2 TNF 24886442 3114620 Positive_regulation TLR2 TNF 24938416 3082514 Positive_regulation TLR2 TNF 25071732 927056 Positive_regulation TLR2 TNF 25093709 34279 Positive_regulation TLR2 TNF 25147831 1623106 Positive_regulation TLR2 TNF 25250027 914196 Positive_regulation TLR2 TNF 25250027 914208 Positive_regulation TLR2 TNF 25329057 3015863 Positive_regulation TLR2 TNF PMC3007769 1702440 Positive_regulation TLR2 TNF PMC3242235 1702518 Positive_regulation TLR2 TNFSF10 25196285 3224129 Positive_regulation TLR3 CD14 20236452 659498 Positive_regulation TLR3 CD14 20706656 1747790 Positive_regulation TLR3 CD14 21078886 1561464 Positive_regulation TLR3 CD14 21789185 2537948 Positive_regulation TLR3 CD14 PMC3109490 927531 Positive_regulation TLR3 CD22 22566885 899540 Positive_regulation TLR3 CLU 24758255 1726856 Positive_regulation TLR3 CYP24A1 21124742 2484007 Positive_regulation TLR3 EPHB2 21860608 1038243 Positive_regulation TLR3 EPHB2 22253793 2587954 Positive_regulation TLR3 EPHB2 22783258 902286 Positive_regulation TLR3 EPHB2 24927726 1684589 Positive_regulation TLR3 IL1B 23936458 2830967 Positive_regulation TLR3 IL1B 24060373 1700521 Positive_regulation TLR3 MMP28 18762577 1355471 Positive_regulation TLR3 MMP28 18762577 1355472 Positive_regulation TLR3 MMP28 18762577 1355473 Positive_regulation TLR3 MMP7 18762577 1355516 Positive_regulation TLR3 MMP7 18762577 1355517 Positive_regulation TLR3 MMP7 18762577 1355518 Positive_regulation TLR3 MUC16 24527027 980786 Positive_regulation TLR3 SCARA3 23717201 3061652 Positive_regulation TLR3 TLR7 17893200 1547126 Positive_regulation TLR3 TLR7 19686596 3118101 Positive_regulation TLR3 TLR7 21364926 2504467 Positive_regulation TLR3 TLR7 21695051 2529268 Positive_regulation TLR3 TLR7 25071732 927124 Positive_regulation TLR3 TNF 18227218 1548810 Positive_regulation TLR3 TNF 19183807 2405079 Positive_regulation TLR3 TNF 19419540 3117775 Positive_regulation TLR3 TNF 21342497 1897895 Positive_regulation TLR3 TNF 21342497 1897907 Positive_regulation TLR3 TNF 21556316 1078203 Positive_regulation TLR3 TNF 21915309 2553168 Positive_regulation TLR3 TNF 21994612 3219016 Positive_regulation TLR3 TNF 22747567 389855 Positive_regulation TLR3 TNF 23283295 3225596 Positive_regulation TLR3 TNF 23484125 179634 Positive_regulation TLR3 TNF 24058791 1705767 Positive_regulation TLR3 TNF 25062998 1620052 Positive_regulation TLR3 TNF 25343451 3019115 Positive_regulation TLR3 TNF 25343451 3019116 Positive_regulation TLR3 TNF 25343451 3019117 Positive_regulation TLR3 TNF PMC3007769 1702442 Positive_regulation TLR3 TNF PMC3242235 1702520 Positive_regulation TLR3 TNFSF10 23370279 559371 Positive_regulation TLR3 TNFSF10 25196285 3224130 Positive_regulation TLR4 ALOX5 25116953 2996582 Positive_regulation TLR4 CAPN8 24489676 2915611 Positive_regulation TLR4 CAPN8 24489676 2915732 Positive_regulation TLR4 CAPN8 24489676 2915774 Positive_regulation TLR4 CAPN8 25258477 1762457 Positive_regulation TLR4 CD14 11104525 993514 Positive_regulation TLR4 CD14 11435474 1519656 Positive_regulation TLR4 CD14 11983038 658326 Positive_regulation TLR4 CD14 14517279 1529119 Positive_regulation TLR4 CD14 14517279 1529125 Positive_regulation TLR4 CD14 16277694 104791 Positive_regulation TLR4 CD14 17997851 1625039 Positive_regulation TLR4 CD14 19594951 734073 Positive_regulation TLR4 CD14 20236452 659499 Positive_regulation TLR4 CD14 20388715 1187033 Positive_regulation TLR4 CD14 20419140 2447167 Positive_regulation TLR4 CD14 20419140 2447171 Positive_regulation TLR4 CD14 20978830 1050609 Positive_regulation TLR4 CD14 21078886 1561465 Positive_regulation TLR4 CD14 21176128 291660 Positive_regulation TLR4 CD14 21356084 354402 Positive_regulation TLR4 CD14 21789185 2537950 Positive_regulation TLR4 CD14 22196451 3201926 Positive_regulation TLR4 CD14 22973518 1079320 Positive_regulation TLR4 CD14 23049772 2699445 Positive_regulation TLR4 CD14 23055710 1071982 Positive_regulation TLR4 CD14 23209313 1570370 Positive_regulation TLR4 CD14 23803652 1108015 Positive_regulation TLR4 CD14 23990939 2840475 Positive_regulation TLR4 CD14 24010102 2234932 Positive_regulation TLR4 CD14 24244872 2233920 Positive_regulation TLR4 CD14 24244872 2233923 Positive_regulation TLR4 CD14 24602493 295928 Positive_regulation TLR4 CD14 24708794 1667961 Positive_regulation TLR4 CD14 25071777 913386 Positive_regulation TLR4 CD14 25161655 913875 Positive_regulation TLR4 CD14 25332099 607549 Positive_regulation TLR4 CD14 25332099 607578 Positive_regulation TLR4 CD14 25332099 607579 Positive_regulation TLR4 CD14 25360682 3021146 Positive_regulation TLR4 CD14 PMC3109490 927532 Positive_regulation TLR4 CD22 22566885 899541 Positive_regulation TLR4 CYP24A1 21124742 2484008 Positive_regulation TLR4 EDN2 18195069 1548427 Positive_regulation TLR4 EPHB2 19667062 1555521 Positive_regulation TLR4 EPHB2 19667062 1555667 Positive_regulation TLR4 EPHB2 22253793 2587956 Positive_regulation TLR4 EPHB2 22610140 1957363 Positive_regulation TLR4 EPHB2 22783258 902288 Positive_regulation TLR4 EPHB2 23185615 2722013 Positive_regulation TLR4 EPHB2 24927726 1684591 Positive_regulation TLR4 EPHB2 25101851 2995831 Positive_regulation TLR4 FAS 20565784 1626075 Positive_regulation TLR4 FAS 22396206 721682 Positive_regulation TLR4 FAS 23349502 725965 Positive_regulation TLR4 FAS 23349502 725972 Positive_regulation TLR4 FAS 24064574 2118059 Positive_regulation TLR4 FAS 24191253 184764 Positive_regulation TLR4 FOXO1 24265696 2884914 Positive_regulation TLR4 FOXO1 24265696 2884922 Positive_regulation TLR4 FOXO1 24864265 191777 Positive_regulation TLR4 FOXO1 24864265 191792 Positive_regulation TLR4 IL1B 23762324 2802999 Positive_regulation TLR4 IL1B 23936458 2830968 Positive_regulation TLR4 IL1B 24060373 1700522 Positive_regulation TLR4 LBP 21356084 354404 Positive_regulation TLR4 LBP 22355383 2597447 Positive_regulation TLR4 LBP 23055710 1071983 Positive_regulation TLR4 LBP 23803652 1108017 Positive_regulation TLR4 LBP 24602493 295929 Positive_regulation TLR4 LBP 25184525 3004851 Positive_regulation TLR4 MIP 24434316 1045855 Positive_regulation TLR4 MMP28 18762577 1355537 Positive_regulation TLR4 MMP28 18762577 1355538 Positive_regulation TLR4 MMP28 18762577 1355539 Positive_regulation TLR4 MMP7 18762577 1355582 Positive_regulation TLR4 MMP7 18762577 1355583 Positive_regulation TLR4 MMP7 18762577 1355584 Positive_regulation TLR4 MUC16 24527027 980801 Positive_regulation TLR4 PECAM1 24434316 1045856 Positive_regulation TLR4 TLR7 19686596 3118102 Positive_regulation TLR4 TLR7 20051129 3110208 Positive_regulation TLR4 TLR7 20098705 2437913 Positive_regulation TLR4 TLR7 22566948 900395 Positive_regulation TLR4 TLR7 23787776 3222816 Positive_regulation TLR4 TLR7 24814708 145445 Positive_regulation TLR4 TLR7 25580138 1703344 Positive_regulation TLR4 TNF 14651749 3095628 Positive_regulation TLR4 TNF 16277694 104790 Positive_regulation TLR4 TNF 16316467 1624850 Positive_regulation TLR4 TNF 17592640 392066 Positive_regulation TLR4 TNF 18227218 1548815 Positive_regulation TLR4 TNF 19183807 2405081 Positive_regulation TLR4 TNF 19284577 112941 Positive_regulation TLR4 TNF 19419540 3117776 Positive_regulation TLR4 TNF 19691558 2232103 Positive_regulation TLR4 TNF 19997599 2432956 Positive_regulation TLR4 TNF 20202224 1228019 Positive_regulation TLR4 TNF 20876708 729655 Positive_regulation TLR4 TNF 20946675 1723332 Positive_regulation TLR4 TNF 20946675 1723333 Positive_regulation TLR4 TNF 21915309 2553169 Positive_regulation TLR4 TNF 21966468 2559050 Positive_regulation TLR4 TNF 22530124 2009498 Positive_regulation TLR4 TNF 22951730 1631216 Positive_regulation TLR4 TNF 23056417 2701498 Positive_regulation TLR4 TNF 23118784 816057 Positive_regulation TLR4 TNF 23186369 1665165 Positive_regulation TLR4 TNF 23283295 3225598 Positive_regulation TLR4 TNF 23484125 179636 Positive_regulation TLR4 TNF 23835343 727910 Positive_regulation TLR4 TNF 23874444 2821340 Positive_regulation TLR4 TNF 24058791 1705770 Positive_regulation TLR4 TNF 24064574 2118058 Positive_regulation TLR4 TNF 24083053 3175364 Positive_regulation TLR4 TNF 24235843 2122408 Positive_regulation TLR4 TNF 24348797 843956 Positive_regulation TLR4 TNF 24595131 2930811 Positive_regulation TLR4 TNF 24672653 1024309 Positive_regulation TLR4 TNF 24733601 88646 Positive_regulation TLR4 TNF 24988481 2986295 Positive_regulation TLR4 TNF 25025559 1162050 Positive_regulation TLR4 TNF 25093709 34255 Positive_regulation TLR4 TNF 25120576 826626 Positive_regulation TLR4 TNF 25170305 1063323 Positive_regulation TLR4 TNF PMC3007769 1702444 Positive_regulation TLR4 TNF PMC3242235 1702522 Positive_regulation TLR4 TNFSF10 25196285 3224131 Positive_regulation TLR4 TP63 22479554 2615928 Positive_regulation TLR5 CD14 20236452 659500 Positive_regulation TLR5 CD14 21078886 1561466 Positive_regulation TLR5 CD14 21789185 2537951 Positive_regulation TLR5 CD14 PMC3109490 927533 Positive_regulation TLR5 CYP24A1 21124742 2484009 Positive_regulation TLR5 EPHB2 22253793 2587958 Positive_regulation TLR5 EPHB2 22783258 902290 Positive_regulation TLR5 EPHB2 24927726 1684593 Positive_regulation TLR5 IL1B 23936458 2830969 Positive_regulation TLR5 IL1B 24060373 1700523 Positive_regulation TLR5 MMP28 18762577 1355603 Positive_regulation TLR5 MMP28 18762577 1355604 Positive_regulation TLR5 MMP28 18762577 1355605 Positive_regulation TLR5 MMP7 18762577 1355648 Positive_regulation TLR5 MMP7 18762577 1355649 Positive_regulation TLR5 MMP7 18762577 1355650 Positive_regulation TLR5 MUC16 24527027 980816 Positive_regulation TLR5 TLR7 17893200 1547128 Positive_regulation TLR5 TLR7 19686596 3118103 Positive_regulation TLR5 TNF 18227218 1548820 Positive_regulation TLR5 TNF 19183807 2405083 Positive_regulation TLR5 TNF 19419540 3117777 Positive_regulation TLR5 TNF 21915309 2553170 Positive_regulation TLR5 TNF 23283295 3225600 Positive_regulation TLR5 TNF 23484125 179638 Positive_regulation TLR5 TNF 24058791 1705773 Positive_regulation TLR5 TNF PMC3007769 1702446 Positive_regulation TLR5 TNF PMC3242235 1702524 Positive_regulation TLR5 TNFSF10 25196285 3224132 Positive_regulation TLR6 CD14 20236452 659505 Positive_regulation TLR6 CD14 21078886 1561471 Positive_regulation TLR6 CD14 21789185 2537957 Positive_regulation TLR6 CD14 23338226 1879467 Positive_regulation TLR6 CD14 25161655 913920 Positive_regulation TLR6 CD14 PMC3109490 927538 Positive_regulation TLR6 CYP24A1 21124742 2484014 Positive_regulation TLR6 EPHB2 22253793 2587978 Positive_regulation TLR6 EPHB2 22783258 902300 Positive_regulation TLR6 EPHB2 24927726 1684603 Positive_regulation TLR6 EPHB2 25598661 1716835 Positive_regulation TLR6 IL1B 23936458 2830974 Positive_regulation TLR6 IL1B 24060373 1700528 Positive_regulation TLR6 MMP28 18762577 1355933 Positive_regulation TLR6 MMP28 18762577 1355934 Positive_regulation TLR6 MMP28 18762577 1355935 Positive_regulation TLR6 MMP7 18762577 1355978 Positive_regulation TLR6 MMP7 18762577 1355979 Positive_regulation TLR6 MMP7 18762577 1355980 Positive_regulation TLR6 MUC16 24527027 980891 Positive_regulation TLR6 TLR7 19686596 3118127 Positive_regulation TLR6 TLR7 22837669 1096340 Positive_regulation TLR6 TNF 18227218 1548855 Positive_regulation TLR6 TNF 19183807 2405105 Positive_regulation TLR6 TNF 19419540 3117792 Positive_regulation TLR6 TNF 21915309 2553195 Positive_regulation TLR6 TNF 23271927 1714684 Positive_regulation TLR6 TNF 23283295 3225610 Positive_regulation TLR6 TNF 23484125 179648 Positive_regulation TLR6 TNF 24058791 1705798 Positive_regulation TLR6 TNF PMC3007769 1702456 Positive_regulation TLR6 TNF PMC3242235 1702544 Positive_regulation TLR6 TNFSF10 25196285 3224147 Positive_regulation TLR7 ACD 25118589 1944936 Positive_regulation TLR7 ADA 22969765 904129 Positive_regulation TLR7 ADAM11 22953039 2233624 Positive_regulation TLR7 AHR 19703987 1556055 Positive_regulation TLR7 AHR 19703987 1556087 Positive_regulation TLR7 AHSA1 22783258 902291 Positive_regulation TLR7 AHSA1 23554538 3674 Positive_regulation TLR7 AHSA1 24927726 1684594 Positive_regulation TLR7 AKT1 18227218 1548836 Positive_regulation TLR7 AKT2 18227218 1548837 Positive_regulation TLR7 AKT3 18227218 1548838 Positive_regulation TLR7 ALDH1A1 19190084 1051221 Positive_regulation TLR7 ALDH1A2 19252500 1960608 Positive_regulation TLR7 ALDH1A2 24788806 2959560 Positive_regulation TLR7 ANXA6 18322684 487940 Positive_regulation TLR7 ANXA6 22815909 2666745 Positive_regulation TLR7 ANXA6 23421931 590820 Positive_regulation TLR7 APCS 24465735 2911571 Positive_regulation TLR7 APOB 23024745 2689674 Positive_regulation TLR7 APOB 23349676 2742918 Positive_regulation TLR7 APOB 24752299 1575950 Positive_regulation TLR7 APOBEC3G 25352838 927336 Positive_regulation TLR7 ARF6 23060951 654205 Positive_regulation TLR7 ARG1 25386178 915029 Positive_regulation TLR7 ARG2 21869919 1680402 Positive_regulation TLR7 ATF3 24317040 1959558 Positive_regulation TLR7 ATF3 24317040 1959578 Positive_regulation TLR7 ATP7A 22610140 1957309 Positive_regulation TLR7 AXL 23071254 1569553 Positive_regulation TLR7 AXL 23071254 1569554 Positive_regulation TLR7 B2M 19075287 1553074 Positive_regulation TLR7 BCL10 21625535 3051879 Positive_regulation TLR7 BCL10 23799152 2807298 Positive_regulation TLR7 BCR 19591639 116074 Positive_regulation TLR7 BCR 21991317 2561352 Positive_regulation TLR7 BCR 23055692 176106 Positive_regulation TLR7 BCR 23505586 2371790 Positive_regulation TLR7 BCR 24692849 1757901 Positive_regulation TLR7 BCR 25132836 913796 Positive_regulation TLR7 BMX 18947379 111740 Positive_regulation TLR7 BTK 18947379 111741 Positive_regulation TLR7 BTK 23967355 2837719 Positive_regulation TLR7 BTK 25170774 3003947 Positive_regulation TLR7 BTK 25170774 3003953 Positive_regulation TLR7 BTK 25170774 3003986 Positive_regulation TLR7 C1orf228 23162549 904997 Positive_regulation TLR7 C3 22442690 2612988 Positive_regulation TLR7 C5 22442690 2612989 Positive_regulation TLR7 CAMP 19703986 1555941 Positive_regulation TLR7 CAMP 19703986 1555995 Positive_regulation TLR7 CAMP 21049021 2480510 Positive_regulation TLR7 CAMP 21765618 1749314 Positive_regulation TLR7 CASP1 25372293 3023053 Positive_regulation TLR7 CBL 23056470 2701687 Positive_regulation TLR7 CCL1 19057661 3042850 Positive_regulation TLR7 CCL2 23762326 2803010 Positive_regulation TLR7 CCL2 PMC4085409 661257 Positive_regulation TLR7 CCL4 24592205 938706 Positive_regulation TLR7 CCNC 18815618 631354 Positive_regulation TLR7 CCR2 PMC4085409 661258 Positive_regulation TLR7 CCR7 24586760 2926337 Positive_regulation TLR7 CD14 20236452 659501 Positive_regulation TLR7 CD14 21078886 1561453 Positive_regulation TLR7 CD14 21078886 1561467 Positive_regulation TLR7 CD14 21789185 2537953 Positive_regulation TLR7 CD14 25309543 914371 Positive_regulation TLR7 CD14 PMC3109490 927534 Positive_regulation TLR7 CD180 18847495 111616 Positive_regulation TLR7 CD180 22661952 957334 Positive_regulation TLR7 CD19 PMC4184230 2236349 Positive_regulation TLR7 CD209 23221477 3217442 Positive_regulation TLR7 CD274 20814675 488073 Positive_regulation TLR7 CD276 24223593 1070211 Positive_regulation TLR7 CD36 23506036 138520 Positive_regulation TLR7 CD36 PMC3007784 1702481 Positive_regulation TLR7 CD40 18652679 352339 Positive_regulation TLR7 CD40 19812695 2427995 Positive_regulation TLR7 CD40LG 16330812 1538711 Positive_regulation TLR7 CD44 23940791 2832458 Positive_regulation TLR7 CD58 18652679 352340 Positive_regulation TLR7 CD69 18382686 2387494 Positive_regulation TLR7 CD70 22851815 1750151 Positive_regulation TLR7 CD79A 23055692 176107 Positive_regulation TLR7 CD79B 23055692 176108 Positive_regulation TLR7 CD80 18652679 352341 Positive_regulation TLR7 CD80 19750096 793741 Positive_regulation TLR7 CD83 21220452 1562356 Positive_regulation TLR7 CD86 19750096 793742 Positive_regulation TLR7 CDK19 18815618 631359 Positive_regulation TLR7 CDK8 18815618 631357 Positive_regulation TLR7 CHUK 22530722 3210306 Positive_regulation TLR7 CHUK 23508732 906393 Positive_regulation TLR7 CHUK 23974100 544217 Positive_regulation TLR7 CISH 19300567 2011612 Positive_regulation TLR7 CISH 23078795 1617584 Positive_regulation TLR7 CLEC2D 24352438 1704382 Positive_regulation TLR7 CLEC7A 12719479 1526980 Positive_regulation TLR7 CLEC7A 19237602 1554161 Positive_regulation TLR7 CNTN2 19088911 2214850 Positive_regulation TLR7 CRH 21541251 936270 Positive_regulation TLR7 CRK 10952730 1516745 Positive_regulation TLR7 CSE 21738617 2532942 Positive_regulation TLR7 CSF1 23533994 180612 Positive_regulation TLR7 CSF2 18219369 1083687 Positive_regulation TLR7 CSF2 19190084 1051262 Positive_regulation TLR7 CSF2 19426550 282384 Positive_regulation TLR7 CSF2 19426550 282385 Positive_regulation TLR7 CSF2 19426550 282651 Positive_regulation TLR7 CSF2 19426550 282652 Positive_regulation TLR7 CSF2 19426550 282653 Positive_regulation TLR7 CSF2 19426550 282673 Positive_regulation TLR7 CSF2 20821041 1491384 Positive_regulation TLR7 CSF2 24788806 2959561 Positive_regulation TLR7 CSF3 20821041 1491385 Positive_regulation TLR7 CSF3 23882270 908280 Positive_regulation TLR7 CSK 22870988 126620 Positive_regulation TLR7 CSK 22880073 2674138 Positive_regulation TLR7 CSK 24558379 2923515 Positive_regulation TLR7 CXCL10 21559444 2519537 Positive_regulation TLR7 CXCL10 23144947 2715089 Positive_regulation TLR7 CXCL10 23824215 2808914 Positive_regulation TLR7 CXCL2 19404403 2415717 Positive_regulation TLR7 CXCL9 15154616 630217 Positive_regulation TLR7 CYP24A1 21124742 2484010 Positive_regulation TLR7 CYP27B1 25089904 2994781 Positive_regulation TLR7 DEFB4A 19503839 2418556 Positive_regulation TLR7 DLL1 22072963 3054542 Positive_regulation TLR7 DLL4 25610519 3225749 Positive_regulation TLR7 DPT 21494377 1038069 Positive_regulation TLR7 DST 24349194 2897030 Positive_regulation TLR7 DUOX1 24455491 864946 Positive_regulation TLR7 DUOX2 24455491 864945 Positive_regulation TLR7 EGFR 20195469 2441893 Positive_regulation TLR7 EGFR 20195469 2441917 Positive_regulation TLR7 EGFR 20195469 2441970 Positive_regulation TLR7 EHF 23185370 2720160 Positive_regulation TLR7 EIF2AK2 20976225 2479488 Positive_regulation TLR7 EIF2AK2 20976225 2479540 Positive_regulation TLR7 EIF4E 22610140 1957308 Positive_regulation TLR7 ELMO1 23143594 1951357 Positive_regulation TLR7 EPHB2 22253793 2587970 Positive_regulation TLR7 EPHB2 22783258 902292 Positive_regulation TLR7 EPHB2 24927726 1684595 Positive_regulation TLR7 GPI 19911079 1213212 Positive_regulation TLR7 HAAO 23922808 2826712 Positive_regulation TLR7 HAVCR2 23967307 2835890 Positive_regulation TLR7 HCK 18947379 111743 Positive_regulation TLR7 HLA-A 19075287 1553072 Positive_regulation TLR7 HLA-DRA 25057505 1622567 Positive_regulation TLR7 HLA-DRB1 25057505 1622568 Positive_regulation TLR7 HMGB1 19476625 1696287 Positive_regulation TLR7 HMGB1 21552240 1921495 Positive_regulation TLR7 HNRNPF 15795237 1535223 Positive_regulation TLR7 HNRNPF 17296788 1544407 Positive_regulation TLR7 HNRNPF 17954572 1547353 Positive_regulation TLR7 HNRNPF 17954572 1547361 Positive_regulation TLR7 HNRNPF 19204112 1553974 Positive_regulation TLR7 HNRNPF 19476613 113405 Positive_regulation TLR7 HNRNPF 20027279 3228904 Positive_regulation TLR7 HNRNPF 20032970 1917763 Positive_regulation TLR7 HNRNPF 21350488 1987035 Positive_regulation TLR7 HNRNPF 21555485 1563751 Positive_regulation TLR7 HNRNPF 23435233 3222241 Positive_regulation TLR7 HNRNPF 23593527 2371849 Positive_regulation TLR7 HNRNPF 23630623 2785329 Positive_regulation TLR7 HNRNPF 23691339 1151704 Positive_regulation TLR7 HNRNPF 23781253 637824 Positive_regulation TLR7 HNRNPF 24598455 132020 Positive_regulation TLR7 HNRNPH1 15795237 1535224 Positive_regulation TLR7 HNRNPH1 17296788 1544408 Positive_regulation TLR7 HNRNPH1 17954572 1547354 Positive_regulation TLR7 HNRNPH1 17954572 1547362 Positive_regulation TLR7 HNRNPH1 19204112 1553975 Positive_regulation TLR7 HNRNPH1 19476613 113406 Positive_regulation TLR7 HNRNPH1 20027279 3228905 Positive_regulation TLR7 HNRNPH1 20032970 1917764 Positive_regulation TLR7 HNRNPH1 21350488 1987036 Positive_regulation TLR7 HNRNPH1 21555485 1563752 Positive_regulation TLR7 HNRNPH1 23435233 3222242 Positive_regulation TLR7 HNRNPH1 23593527 2371850 Positive_regulation TLR7 HNRNPH1 23630623 2785330 Positive_regulation TLR7 HNRNPH1 23691339 1151705 Positive_regulation TLR7 HNRNPH1 23781253 637825 Positive_regulation TLR7 HNRNPH1 24598455 132021 Positive_regulation TLR7 HRAS 25118589 1945176 Positive_regulation TLR7 HRH4 23532396 1050480 Positive_regulation TLR7 IDO1 PMC2767783 3125177 Positive_regulation TLR7 IFI16 25276842 1623278 Positive_regulation TLR7 IFN1@ 19624844 116088 Positive_regulation TLR7 IFN1@ 19624844 116089 Positive_regulation TLR7 IFN1@ 19624844 116097 Positive_regulation TLR7 IFNA1 23131071 3120787 Positive_regulation TLR7 IFNA10 23131071 3120788 Positive_regulation TLR7 IFNA13 23131071 3120789 Positive_regulation TLR7 IFNA14 23131071 3120790 Positive_regulation TLR7 IFNA16 23131071 3120791 Positive_regulation TLR7 IFNA17 23131071 3120792 Positive_regulation TLR7 IFNA2 23131071 3120793 Positive_regulation TLR7 IFNA21 23131071 3120794 Positive_regulation TLR7 IFNA4 23131071 3120795 Positive_regulation TLR7 IFNA5 23131071 3120796 Positive_regulation TLR7 IFNA6 23131071 3120797 Positive_regulation TLR7 IFNA7 23131071 3120798 Positive_regulation TLR7 IFNA8 23131071 3120799 Positive_regulation TLR7 IFNAR2 19624844 116100 Positive_regulation TLR7 IFNB1 22727118 1663609 Positive_regulation TLR7 IFNB1 25356432 87896 Positive_regulation TLR7 IFNG 23781340 1497093 Positive_regulation TLR7 IFNL1 24286242 130864 Positive_regulation TLR7 IFNL1 24286242 130966 Positive_regulation TLR7 IGKV1-27 18268035 1549198 Positive_regulation TLR7 IGKV1-27 24917867 913074 Positive_regulation TLR7 IKBKB 22530722 3210308 Positive_regulation TLR7 IKBKB 23508732 906394 Positive_regulation TLR7 IKBKB 23974100 544218 Positive_regulation TLR7 IKBKG 22530722 3210309 Positive_regulation TLR7 IKBKG 23508732 906395 Positive_regulation TLR7 IKBKG 23825957 3062913 Positive_regulation TLR7 IKBKG 23974100 544219 Positive_regulation TLR7 IL10 12391011 1525067 Positive_regulation TLR7 IL10 17918201 807172 Positive_regulation TLR7 IL10 19667062 1555527 Positive_regulation TLR7 IL10 20672047 1747587 Positive_regulation TLR7 IL10 20803699 1050204 Positive_regulation TLR7 IL10 20862346 979365 Positive_regulation TLR7 IL10 21124820 3050092 Positive_regulation TLR7 IL10 21220452 1562357 Positive_regulation TLR7 IL10 21991534 1151554 Positive_regulation TLR7 IL10 22737608 2161014 Positive_regulation TLR7 IL10 23283295 3225603 Positive_regulation TLR7 IL10 23408948 2752946 Positive_regulation TLR7 IL10 23533309 1751793 Positive_regulation TLR7 IL10 23826189 2810738 Positive_regulation TLR7 IL10 25071732 927127 Positive_regulation TLR7 IL10 PMC3007769 1702449 Positive_regulation TLR7 IL10 PMC3760629 1605977 Positive_regulation TLR7 IL12A 12045249 1523541 Positive_regulation TLR7 IL12A 18322684 487941 Positive_regulation TLR7 IL12A 20862346 979411 Positive_regulation TLR7 IL12A 22815909 2666746 Positive_regulation TLR7 IL12A 23408948 2752947 Positive_regulation TLR7 IL12A 23421931 590821 Positive_regulation TLR7 IL12A 23448601 535750 Positive_regulation TLR7 IL12A 23735002 2231677 Positive_regulation TLR7 IL12A 23758787 1649577 Positive_regulation TLR7 IL12A 24058791 1705787 Positive_regulation TLR7 IL12A 24224170 184887 Positive_regulation TLR7 IL12B 12045249 1523542 Positive_regulation TLR7 IL12B 18322684 487942 Positive_regulation TLR7 IL12B 20862346 979412 Positive_regulation TLR7 IL12B 22815909 2666747 Positive_regulation TLR7 IL12B 23408948 2752948 Positive_regulation TLR7 IL12B 23421931 590822 Positive_regulation TLR7 IL12B 23448601 535751 Positive_regulation TLR7 IL12B 23735002 2231678 Positive_regulation TLR7 IL12B 23758787 1649578 Positive_regulation TLR7 IL12B 24058791 1705788 Positive_regulation TLR7 IL12B 24224170 184888 Positive_regulation TLR7 IL12B 24386404 2903865 Positive_regulation TLR7 IL15 18458113 1550788 Positive_regulation TLR7 IL15 18458113 1550808 Positive_regulation TLR7 IL17A 24740301 2954617 Positive_regulation TLR7 IL17D 25386143 954983 Positive_regulation TLR7 IL18 20862346 979413 Positive_regulation TLR7 IL18 21994762 3220160 Positive_regulation TLR7 IL18 22110538 633604 Positive_regulation TLR7 IL1A 17615075 320491 Positive_regulation TLR7 IL1A 21994762 3220161 Positive_regulation TLR7 IL1A 22110538 633605 Positive_regulation TLR7 IL1A 22484733 1957083 Positive_regulation TLR7 IL1A 23036692 126930 Positive_regulation TLR7 IL1A 23484125 179641 Positive_regulation TLR7 IL1A 23666718 780718 Positive_regulation TLR7 IL1A 23690962 2793977 Positive_regulation TLR7 IL1A 23782429 3204411 Positive_regulation TLR7 IL1A 23839215 1732385 Positive_regulation TLR7 IL1A 24224170 184889 Positive_regulation TLR7 IL1A 24400125 2905911 Positive_regulation TLR7 IL1A 24987391 926817 Positive_regulation TLR7 IL1A 25372293 3023055 Positive_regulation TLR7 IL1B 23936458 2830970 Positive_regulation TLR7 IL1B 24060373 1700524 Positive_regulation TLR7 IL1R1 15809356 1535367 Positive_regulation TLR7 IL1R1 20531401 1903565 Positive_regulation TLR7 IL22 24740301 2954616 Positive_regulation TLR7 IL23A 24386404 2903864 Positive_regulation TLR7 IL33 22110538 633603 Positive_regulation TLR7 IL33 23653627 906964 Positive_regulation TLR7 IL33 23653627 906979 Positive_regulation TLR7 IL37 20935647 1954521 Positive_regulation TLR7 IL37 25226272 3007700 Positive_regulation TLR7 IL4 23861935 2820882 Positive_regulation TLR7 IL6 18227218 1548839 Positive_regulation TLR7 IL6 19183807 2405097 Positive_regulation TLR7 IL6 19703985 1555900 Positive_regulation TLR7 IL6 20680494 1654633 Positive_regulation TLR7 IL6 23758787 1649579 Positive_regulation TLR7 IL6 24009850 203827 Positive_regulation TLR7 IL6 24224170 184890 Positive_regulation TLR7 IL6 24987391 926818 Positive_regulation TLR7 IL6 PMC3242235 1702537 Positive_regulation TLR7 IL7 24740301 2954622 Positive_regulation TLR7 IL7 24740301 2954627 Positive_regulation TLR7 IL8 18053251 3212083 Positive_regulation TLR7 IL8 21556316 1078210 Positive_regulation TLR7 IL8 23782429 3204412 Positive_regulation TLR7 IL8 24164922 399461 Positive_regulation TLR7 IL8 25136145 1760837 Positive_regulation TLR7 IL9 22783250 902092 Positive_regulation TLR7 INPP5D 22876243 902759 Positive_regulation TLR7 INPP5D 23078795 1617372 Positive_regulation TLR7 INS 18556339 729024 Positive_regulation TLR7 IRAK1 15767370 1534885 Positive_regulation TLR7 IRAK1 15767370 1534901 Positive_regulation TLR7 IRAK1 15767370 1534904 Positive_regulation TLR7 IRAK1 15804356 3104892 Positive_regulation TLR7 IRAK1 16606665 1539933 Positive_regulation TLR7 IRAK1 16606665 1539958 Positive_regulation TLR7 IRAK1 17485511 1545562 Positive_regulation TLR7 IRAK1 22393448 2608208 Positive_regulation TLR7 IRAK1 23078795 1617551 Positive_regulation TLR7 IRAK1 23508732 906396 Positive_regulation TLR7 IRAK1 24232746 185021 Positive_regulation TLR7 IRAK2 22393448 2608209 Positive_regulation TLR7 IRAK2 24232746 185022 Positive_regulation TLR7 IRAK3 20929569 403145 Positive_regulation TLR7 IRAK3 20929569 403332 Positive_regulation TLR7 IRAK3 21108806 1626219 Positive_regulation TLR7 IRAK3 21390243 1049838 Positive_regulation TLR7 IRAK3 21811575 2539597 Positive_regulation TLR7 IRAK3 22393448 2608205 Positive_regulation TLR7 IRAK3 22928050 2681721 Positive_regulation TLR7 IRAK3 22928050 2681826 Positive_regulation TLR7 IRAK3 22928050 2681933 Positive_regulation TLR7 IRAK3 23437317 2756438 Positive_regulation TLR7 IRAK3 24232746 185019 Positive_regulation TLR7 IRAK4 17470642 1545469 Positive_regulation TLR7 IRAK4 17470642 1545470 Positive_regulation TLR7 IRAK4 17470642 1545471 Positive_regulation TLR7 IRAK4 17470642 1545520 Positive_regulation TLR7 IRAK4 17485511 1545719 Positive_regulation TLR7 IRAK4 17893200 1547117 Positive_regulation TLR7 IRAK4 19689377 694764 Positive_regulation TLR7 IRAK4 21197425 979786 Positive_regulation TLR7 IRAK4 22393448 2608206 Positive_regulation TLR7 IRAK4 23994464 1051342 Positive_regulation TLR7 IRAK4 24232746 185020 Positive_regulation TLR7 IRAK4 25309543 914369 Positive_regulation TLR7 IRF3 21408089 2275278 Positive_regulation TLR7 IRF3 21625524 2524679 Positive_regulation TLR7 IRF4 21387014 2506168 Positive_regulation TLR7 IRF4 23658517 3061003 Positive_regulation TLR7 IRF5 21253574 3050457 Positive_regulation TLR7 IRF5 21826793 776693 Positive_regulation TLR7 IRF5 23300459 3060290 Positive_regulation TLR7 IRF5 23514422 1683666 Positive_regulation TLR7 IRF7 19801985 1953251 Positive_regulation TLR7 IRF7 21893536 2250061 Positive_regulation TLR7 IRF7 21994626 3219502 Positive_regulation TLR7 IRF7 24489947 2917046 Positive_regulation TLR7 ISG15 24056597 1045733 Positive_regulation TLR7 ISG20 24056597 1045734 Positive_regulation TLR7 ITGAM 19343210 3043617 Positive_regulation TLR7 ITIH4 24312095 910061 Positive_regulation TLR7 JAK2 23295066 1733900 Positive_regulation TLR7 JUN 19682366 326174 Positive_regulation TLR7 JUN 24217713 2157725 Positive_regulation TLR7 KCNMA1 23584137 3185179 Positive_regulation TLR7 KCNN4 20808895 3048418 Positive_regulation TLR7 KLRAP1 19075287 1553073 Positive_regulation TLR7 KLRAP1 20934454 1042660 Positive_regulation TLR7 KRAS 25118589 1945177 Positive_regulation TLR7 LANCL1 23735002 2231679 Positive_regulation TLR7 LEP 23800102 2111875 Positive_regulation TLR7 LGALS9 23967307 2835891 Positive_regulation TLR7 LGALS9 23967307 2836064 Positive_regulation TLR7 LILRA4 24586760 2926335 Positive_regulation TLR7 LILRB4 23450201 906161 Positive_regulation TLR7 LPA 23024745 2689675 Positive_regulation TLR7 LPA 23349676 2742919 Positive_regulation TLR7 LRRFIP1 23435233 3222243 Positive_regulation TLR7 LTA 23031213 3113143 Positive_regulation TLR7 LTB 24634497 1624523 Positive_regulation TLR7 LY96 25415198 3224419 Positive_regulation TLR7 LYN PMC4291836 541285 Positive_regulation TLR7 MAL 22685567 2650361 Positive_regulation TLR7 MALT1 21625535 3051878 Positive_regulation TLR7 MALT1 23799152 2807297 Positive_regulation TLR7 MAP3K5 21064192 775618 Positive_regulation TLR7 MAP3K7 16418393 1539258 Positive_regulation TLR7 MAP3K8 19667062 1555528 Positive_regulation TLR7 MAPK1 19543526 2419806 Positive_regulation TLR7 MAPK1 22530722 3210310 Positive_regulation TLR7 MAPK10 22530722 3210311 Positive_regulation TLR7 MAPK11 22530722 3210312 Positive_regulation TLR7 MAPK12 22530722 3210313 Positive_regulation TLR7 MAPK13 22530722 3210314 Positive_regulation TLR7 MAPK14 22530722 3210315 Positive_regulation TLR7 MAPK15 22530722 3210307 Positive_regulation TLR7 MAPK3 19543526 2419807 Positive_regulation TLR7 MAPK3 22530722 3210316 Positive_regulation TLR7 MAPK3 24725889 1483041 Positive_regulation TLR7 MAPK4 22530722 3210317 Positive_regulation TLR7 MAPK6 22530722 3210318 Positive_regulation TLR7 MAPK7 22530722 3210319 Positive_regulation TLR7 MAPK8 22530722 3210320 Positive_regulation TLR7 MAPK9 22530722 3210321 Positive_regulation TLR7 MAPKAP1 24740015 2953961 Positive_regulation TLR7 MAPKAP1 24740015 2954458 Positive_regulation TLR7 MARCO 22182475 334890 Positive_regulation TLR7 MDM1 21904615 2550498 Positive_regulation TLR7 MDM2 21904615 2550499 Positive_regulation TLR7 MDM4 21904615 2550500 Positive_regulation TLR7 MED1 18815618 631381 Positive_regulation TLR7 MED1 22691272 126219 Positive_regulation TLR7 MED10 18815618 631377 Positive_regulation TLR7 MED10 22691272 126214 Positive_regulation TLR7 MED11 18815618 631380 Positive_regulation TLR7 MED11 22691272 126217 Positive_regulation TLR7 MED12 18815618 631352 Positive_regulation TLR7 MED13 18815618 631362 Positive_regulation TLR7 MED13 22691272 126201 Positive_regulation TLR7 MED13L 18815618 631363 Positive_regulation TLR7 MED13L 22691272 126202 Positive_regulation TLR7 MED14 18815618 631367 Positive_regulation TLR7 MED14 22691272 126206 Positive_regulation TLR7 MED15 18815618 631353 Positive_regulation TLR7 MED15 22691272 126195 Positive_regulation TLR7 MED16 18815618 631356 Positive_regulation TLR7 MED16 22691272 126197 Positive_regulation TLR7 MED17 18815618 631369 Positive_regulation TLR7 MED17 22691272 126208 Positive_regulation TLR7 MED18 18815618 631376 Positive_regulation TLR7 MED18 22691272 126213 Positive_regulation TLR7 MED19 18815618 631379 Positive_regulation TLR7 MED19 22691272 126216 Positive_regulation TLR7 MED20 18815618 631355 Positive_regulation TLR7 MED20 22691272 126196 Positive_regulation TLR7 MED21 18815618 631350 Positive_regulation TLR7 MED21 22691272 126192 Positive_regulation TLR7 MED22 18815618 631351 Positive_regulation TLR7 MED22 22691272 126193 Positive_regulation TLR7 MED23 18815618 631368 Positive_regulation TLR7 MED23 22691272 126207 Positive_regulation TLR7 MED24 18815618 631364 Positive_regulation TLR7 MED24 22691272 126203 Positive_regulation TLR7 MED25 18815618 631378 Positive_regulation TLR7 MED25 22691272 126215 Positive_regulation TLR7 MED26 18815618 631370 Positive_regulation TLR7 MED26 22691272 126209 Positive_regulation TLR7 MED27 18815618 631371 Positive_regulation TLR7 MED27 22691272 126210 Positive_regulation TLR7 MED28 18815618 631374 Positive_regulation TLR7 MED29 18815618 631366 Positive_regulation TLR7 MED29 22691272 126205 Positive_regulation TLR7 MED30 18815618 631365 Positive_regulation TLR7 MED30 22691272 126204 Positive_regulation TLR7 MED31 18815618 631373 Positive_regulation TLR7 MED31 22691272 126212 Positive_regulation TLR7 MED4 18815618 631358 Positive_regulation TLR7 MED4 22691272 126198 Positive_regulation TLR7 MED6 18815618 631360 Positive_regulation TLR7 MED6 22691272 126199 Positive_regulation TLR7 MED7 18815618 631372 Positive_regulation TLR7 MED7 22691272 126211 Positive_regulation TLR7 MED8 18815618 631361 Positive_regulation TLR7 MED8 22691272 126200 Positive_regulation TLR7 MED9 18815618 631375 Positive_regulation TLR7 MIF 21977228 2559792 Positive_regulation TLR7 MIR155 22785227 1919004 Positive_regulation TLR7 MIR15A 19891781 326919 Positive_regulation TLR7 MKL1 21203418 2489954 Positive_regulation TLR7 MLST8 24740015 2953962 Positive_regulation TLR7 MLST8 24740015 2954459 Positive_regulation TLR7 MMP1 18762577 1355672 Positive_regulation TLR7 MMP1 18762577 1355673 Positive_regulation TLR7 MMP1 18762577 1355674 Positive_regulation TLR7 MMP10 18762577 1355675 Positive_regulation TLR7 MMP10 18762577 1355676 Positive_regulation TLR7 MMP10 18762577 1355677 Positive_regulation TLR7 MMP11 18762577 1355678 Positive_regulation TLR7 MMP11 18762577 1355679 Positive_regulation TLR7 MMP11 18762577 1355680 Positive_regulation TLR7 MMP12 18762577 1355681 Positive_regulation TLR7 MMP12 18762577 1355682 Positive_regulation TLR7 MMP12 18762577 1355683 Positive_regulation TLR7 MMP13 18762577 1355684 Positive_regulation TLR7 MMP13 18762577 1355685 Positive_regulation TLR7 MMP13 18762577 1355686 Positive_regulation TLR7 MMP13 22720048 2654338 Positive_regulation TLR7 MMP14 18762577 1355687 Positive_regulation TLR7 MMP14 18762577 1355688 Positive_regulation TLR7 MMP14 18762577 1355689 Positive_regulation TLR7 MMP15 18762577 1355690 Positive_regulation TLR7 MMP15 18762577 1355691 Positive_regulation TLR7 MMP15 18762577 1355692 Positive_regulation TLR7 MMP16 18762577 1355693 Positive_regulation TLR7 MMP16 18762577 1355694 Positive_regulation TLR7 MMP16 18762577 1355695 Positive_regulation TLR7 MMP17 18762577 1355696 Positive_regulation TLR7 MMP17 18762577 1355697 Positive_regulation TLR7 MMP17 18762577 1355698 Positive_regulation TLR7 MMP19 18762577 1355699 Positive_regulation TLR7 MMP19 18762577 1355700 Positive_regulation TLR7 MMP19 18762577 1355701 Positive_regulation TLR7 MMP2 18762577 1355702 Positive_regulation TLR7 MMP2 18762577 1355703 Positive_regulation TLR7 MMP2 18762577 1355704 Positive_regulation TLR7 MMP20 18762577 1355705 Positive_regulation TLR7 MMP20 18762577 1355706 Positive_regulation TLR7 MMP20 18762577 1355707 Positive_regulation TLR7 MMP21 18762577 1355666 Positive_regulation TLR7 MMP21 18762577 1355667 Positive_regulation TLR7 MMP21 18762577 1355668 Positive_regulation TLR7 MMP24 18762577 1355708 Positive_regulation TLR7 MMP24 18762577 1355709 Positive_regulation TLR7 MMP24 18762577 1355710 Positive_regulation TLR7 MMP25 18762577 1355657 Positive_regulation TLR7 MMP25 18762577 1355658 Positive_regulation TLR7 MMP25 18762577 1355659 Positive_regulation TLR7 MMP26 18762577 1355660 Positive_regulation TLR7 MMP26 18762577 1355661 Positive_regulation TLR7 MMP26 18762577 1355662 Positive_regulation TLR7 MMP27 18762577 1355663 Positive_regulation TLR7 MMP27 18762577 1355664 Positive_regulation TLR7 MMP27 18762577 1355665 Positive_regulation TLR7 MMP28 18762577 1355669 Positive_regulation TLR7 MMP28 18762577 1355670 Positive_regulation TLR7 MMP28 18762577 1355671 Positive_regulation TLR7 MMP3 18762577 1355711 Positive_regulation TLR7 MMP3 18762577 1355712 Positive_regulation TLR7 MMP3 18762577 1355713 Positive_regulation TLR7 MMP7 18762577 1355714 Positive_regulation TLR7 MMP7 18762577 1355715 Positive_regulation TLR7 MMP7 18762577 1355716 Positive_regulation TLR7 MMP8 18762577 1355717 Positive_regulation TLR7 MMP8 18762577 1355718 Positive_regulation TLR7 MMP8 18762577 1355719 Positive_regulation TLR7 MMP9 18762577 1355720 Positive_regulation TLR7 MMP9 18762577 1355721 Positive_regulation TLR7 MMP9 18762577 1355722 Positive_regulation TLR7 MMP9 22720048 2654339 Positive_regulation TLR7 MRE11A 25118589 1944098 Positive_regulation TLR7 MSC 25132856 3174472 Positive_regulation TLR7 MTA1 25117662 2996863 Positive_regulation TLR7 MTA2 25117662 2996864 Positive_regulation TLR7 MTA3 25117662 2996862 Positive_regulation TLR7 MTOR 24740015 2953964 Positive_regulation TLR7 MTOR 24740015 2954461 Positive_regulation TLR7 MTOR 25200751 3145514 Positive_regulation TLR7 MUC1 24527027 980836 Positive_regulation TLR7 MUC1 24968021 2984006 Positive_regulation TLR7 MUC12 24527027 980837 Positive_regulation TLR7 MUC13 24527027 980838 Positive_regulation TLR7 MUC15 24527027 980830 Positive_regulation TLR7 MUC16 24527027 980831 Positive_regulation TLR7 MUC17 24527027 980832 Positive_regulation TLR7 MUC19 24527027 980829 Positive_regulation TLR7 MUC2 24527027 980839 Positive_regulation TLR7 MUC20 24527027 980834 Positive_regulation TLR7 MUC21 24527027 980833 Positive_regulation TLR7 MUC22 24527027 980835 Positive_regulation TLR7 MUC4 24527027 980840 Positive_regulation TLR7 MUC6 24527027 980841 Positive_regulation TLR7 MUC7 24527027 980842 Positive_regulation TLR7 MUC8 24527027 980843 Positive_regulation TLR7 MYD88 17145958 1543570 Positive_regulation TLR7 MYD88 17502662 1546172 Positive_regulation TLR7 MYD88 18039950 1547857 Positive_regulation TLR7 MYD88 18268035 1549066 Positive_regulation TLR7 MYD88 18268035 1549067 Positive_regulation TLR7 MYD88 18268035 1549068 Positive_regulation TLR7 MYD88 18268035 1549143 Positive_regulation TLR7 MYD88 18268035 1549144 Positive_regulation TLR7 MYD88 18268035 1549159 Positive_regulation TLR7 MYD88 18268035 1549199 Positive_regulation TLR7 MYD88 18268035 1549294 Positive_regulation TLR7 MYD88 18350123 630952 Positive_regulation TLR7 MYD88 18615183 3074318 Positive_regulation TLR7 MYD88 18615183 3074333 Positive_regulation TLR7 MYD88 18615183 3074334 Positive_regulation TLR7 MYD88 19043561 3042827 Positive_regulation TLR7 MYD88 19047436 1552948 Positive_regulation TLR7 MYD88 19064699 1553032 Positive_regulation TLR7 MYD88 19204112 1553869 Positive_regulation TLR7 MYD88 19341611 3209677 Positive_regulation TLR7 MYD88 19343210 3043640 Positive_regulation TLR7 MYD88 19564352 1555323 Positive_regulation TLR7 MYD88 19578435 3044324 Positive_regulation TLR7 MYD88 19652017 1555509 Positive_regulation TLR7 MYD88 19689377 694765 Positive_regulation TLR7 MYD88 19689377 694800 Positive_regulation TLR7 MYD88 19734906 1952950 Positive_regulation TLR7 MYD88 19734906 1952951 Positive_regulation TLR7 MYD88 19734906 1952971 Positive_regulation TLR7 MYD88 19734906 1953091 Positive_regulation TLR7 MYD88 19801985 1953252 Positive_regulation TLR7 MYD88 20221448 2442903 Positive_regulation TLR7 MYD88 20396389 1747323 Positive_regulation TLR7 MYD88 20473309 1961026 Positive_regulation TLR7 MYD88 20473309 1961037 Positive_regulation TLR7 MYD88 20531401 1903566 Positive_regulation TLR7 MYD88 20661430 3048186 Positive_regulation TLR7 MYD88 20668698 2457397 Positive_regulation TLR7 MYD88 20668698 2457439 Positive_regulation TLR7 MYD88 20886104 3048829 Positive_regulation TLR7 MYD88 21078886 1561454 Positive_regulation TLR7 MYD88 21078886 1561460 Positive_regulation TLR7 MYD88 21203418 2489957 Positive_regulation TLR7 MYD88 21251300 3213905 Positive_regulation TLR7 MYD88 21496301 1658220 Positive_regulation TLR7 MYD88 21625574 3051925 Positive_regulation TLR7 MYD88 21625574 3051969 Positive_regulation TLR7 MYD88 21747787 923017 Positive_regulation TLR7 MYD88 21808234 1717727 Positive_regulation TLR7 MYD88 21845181 955703 Positive_regulation TLR7 MYD88 21893536 2250037 Positive_regulation TLR7 MYD88 21893536 2250062 Positive_regulation TLR7 MYD88 21931552 3053371 Positive_regulation TLR7 MYD88 21943186 3112612 Positive_regulation TLR7 MYD88 21991263 923565 Positive_regulation TLR7 MYD88 22074389 354823 Positive_regulation TLR7 MYD88 22216838 660128 Positive_regulation TLR7 MYD88 22419116 1918727 Positive_regulation TLR7 MYD88 22427976 2610820 Positive_regulation TLR7 MYD88 22529866 1703293 Positive_regulation TLR7 MYD88 22570668 634746 Positive_regulation TLR7 MYD88 22685567 2650362 Positive_regulation TLR7 MYD88 22737610 2161057 Positive_regulation TLR7 MYD88 22741533 381945 Positive_regulation TLR7 MYD88 22745710 2655853 Positive_regulation TLR7 MYD88 22807671 3057836 Positive_regulation TLR7 MYD88 22911267 3058905 Positive_regulation TLR7 MYD88 22928050 2681722 Positive_regulation TLR7 MYD88 22951718 1631089 Positive_regulation TLR7 MYD88 22973499 1764579 Positive_regulation TLR7 MYD88 23055935 3059594 Positive_regulation TLR7 MYD88 23055935 3059595 Positive_regulation TLR7 MYD88 23055935 3059628 Positive_regulation TLR7 MYD88 23055935 3059647 Positive_regulation TLR7 MYD88 23055935 3059680 Positive_regulation TLR7 MYD88 23055935 3059696 Positive_regulation TLR7 MYD88 23055935 3059697 Positive_regulation TLR7 MYD88 23078795 1617257 Positive_regulation TLR7 MYD88 23078795 1617258 Positive_regulation TLR7 MYD88 23299509 1022873 Positive_regulation TLR7 MYD88 23300722 2735638 Positive_regulation TLR7 MYD88 23349877 2743894 Positive_regulation TLR7 MYD88 23471913 740236 Positive_regulation TLR7 MYD88 23483993 2764944 Positive_regulation TLR7 MYD88 23484159 179776 Positive_regulation TLR7 MYD88 23497717 128065 Positive_regulation TLR7 MYD88 23514422 1683667 Positive_regulation TLR7 MYD88 23519558 906652 Positive_regulation TLR7 MYD88 23519558 906653 Positive_regulation TLR7 MYD88 23526298 665396 Positive_regulation TLR7 MYD88 23527272 2770303 Positive_regulation TLR7 MYD88 23527272 2770368 Positive_regulation TLR7 MYD88 23527272 2770412 Positive_regulation TLR7 MYD88 23593011 2345136 Positive_regulation TLR7 MYD88 23690823 637378 Positive_regulation TLR7 MYD88 23745124 907346 Positive_regulation TLR7 MYD88 23758787 1649507 Positive_regulation TLR7 MYD88 23762026 3061921 Positive_regulation TLR7 MYD88 23882270 908259 Positive_regulation TLR7 MYD88 24098508 2857848 Positive_regulation TLR7 MYD88 24130498 3064578 Positive_regulation TLR7 MYD88 24146959 2869082 Positive_regulation TLR7 MYD88 24232746 185023 Positive_regulation TLR7 MYD88 24252328 178843 Positive_regulation TLR7 MYD88 24386204 2903241 Positive_regulation TLR7 MYD88 24489933 2916758 Positive_regulation TLR7 MYD88 24505488 2921057 Positive_regulation TLR7 MYD88 24514026 773678 Positive_regulation TLR7 MYD88 24586659 2925985 Positive_regulation TLR7 MYD88 24586659 2926023 Positive_regulation TLR7 MYD88 24586659 2926084 Positive_regulation TLR7 MYD88 24632597 1941007 Positive_regulation TLR7 MYD88 24705038 2948721 Positive_regulation TLR7 MYD88 24917867 913075 Positive_regulation TLR7 MYD88 24967703 3068234 Positive_regulation TLR7 MYD88 25034608 3144647 Positive_regulation TLR7 MYD88 25050810 2991038 Positive_regulation TLR7 MYD88 25076492 2993385 Positive_regulation TLR7 MYD88 25161655 913936 Positive_regulation TLR7 MYD88 25170774 3003961 Positive_regulation TLR7 MYD88 25170774 3003987 Positive_regulation TLR7 MYD88 25232836 3008136 Positive_regulation TLR7 MYD88 25346729 914748 Positive_regulation TLR7 MYD88 25538689 927470 Positive_regulation TLR7 MYD88 25538689 927480 Positive_regulation TLR7 MYLIP 19390647 1746591 Positive_regulation TLR7 MYLIP 19891781 326918 Positive_regulation TLR7 MYLIP 20041145 2435444 Positive_regulation TLR7 MYLIP 21029443 3111557 Positive_regulation TLR7 MYLIP 21188194 139534 Positive_regulation TLR7 MYLIP 22393448 2608207 Positive_regulation TLR7 MYLIP 22518321 1079138 Positive_regulation TLR7 MYLIP 22661952 957332 Positive_regulation TLR7 MYLIP 22661952 957433 Positive_regulation TLR7 MYLIP 23379780 127917 Positive_regulation TLR7 MYLIP 23468661 2343504 Positive_regulation TLR7 MYLIP 23506673 1036556 Positive_regulation TLR7 MYLIP 23516655 2371803 Positive_regulation TLR7 MYLIP 23519132 883502 Positive_regulation TLR7 MYLIP 23633945 3060767 Positive_regulation TLR7 MYLIP 23951138 2833506 Positive_regulation TLR7 MYLIP 23983769 638430 Positive_regulation TLR7 MYLIP 23988154 3122225 Positive_regulation TLR7 MYLIP 24682221 2947137 Positive_regulation TLR7 MYLIP 24682221 2947159 Positive_regulation TLR7 MYLIP 24705038 2948754 Positive_regulation TLR7 MYLIP 24705038 2948755 Positive_regulation TLR7 MYLIP 24800233 190010 Positive_regulation TLR7 MYLIP 25104400 224530 Positive_regulation TLR7 MYLIP 25295261 200759 Positive_regulation TLR7 MYLIP PMC3109490 927548 Positive_regulation TLR7 NAALADL1 25003083 647414 Positive_regulation TLR7 NELFCD 17254349 1695626 Positive_regulation TLR7 NELFCD 19381284 2370398 Positive_regulation TLR7 NELFCD 19915722 2220335 Positive_regulation TLR7 NELFCD 20032970 1917761 Positive_regulation TLR7 NELFCD 23028609 2691853 Positive_regulation TLR7 NELFCD 23271916 1162543 Positive_regulation TLR7 NELFCD 24740301 2954611 Positive_regulation TLR7 NEU1 25187624 761265 Positive_regulation TLR7 NEU1 25187624 761489 Positive_regulation TLR7 NFAT5 22312110 1567231 Positive_regulation TLR7 NFKB1 20808962 2473191 Positive_regulation TLR7 NFKB1 21044333 659698 Positive_regulation TLR7 NFKB1 22566904 899774 Positive_regulation TLR7 NLRP3 23666718 780717 Positive_regulation TLR7 NLRP3 25372293 3023054 Positive_regulation TLR7 NLRP3 25525300 1763307 Positive_regulation TLR7 NOD1 16418393 1539257 Positive_regulation TLR7 NOD2 23977330 2840020 Positive_regulation TLR7 NOD2 25423082 3029842 Positive_regulation TLR7 NOS1 25309919 201159 Positive_regulation TLR7 NOS2 22530722 3210322 Positive_regulation TLR7 NOS2 22615562 3056691 Positive_regulation TLR7 NOS2 23349802 2743311 Positive_regulation TLR7 NOS2 25083878 2993997 Positive_regulation TLR7 NOS2 25309919 201160 Positive_regulation TLR7 NOS3 25309919 201161 Positive_regulation TLR7 NOX1 20532218 3047261 Positive_regulation TLR7 NOX4 20532218 3047262 Positive_regulation TLR7 NPY4R 24586659 2925947 Positive_regulation TLR7 NPY4R 24586659 2926063 Positive_regulation TLR7 NRAS 25118589 1945178 Positive_regulation TLR7 OAS1 23824215 2808915 Positive_regulation TLR7 OAS2 23824215 2808916 Positive_regulation TLR7 OAS3 23824215 2808917 Positive_regulation TLR7 OLR1 14699082 1530481 Positive_regulation TLR7 OPA1 22691272 126218 Positive_regulation TLR7 PAM 20808895 3048419 Positive_regulation TLR7 PAM 22870988 126621 Positive_regulation TLR7 PAM 22880073 2674139 Positive_regulation TLR7 PAM 23875738 1700179 Positive_regulation TLR7 PAM 24558379 2923516 Positive_regulation TLR7 PAM 25003083 647415 Positive_regulation TLR7 PANX1 23738776 213598 Positive_regulation TLR7 PARP1 25118589 1944096 Positive_regulation TLR7 PDC 22414065 398549 Positive_regulation TLR7 PDLIM7 22952664 2683560 Positive_regulation TLR7 PELI1 19734906 1953004 Positive_regulation TLR7 PELI1 19734906 1953092 Positive_regulation TLR7 PELI1 23603814 1962987 Positive_regulation TLR7 PELI1 23603814 1962988 Positive_regulation TLR7 PFN1 23735002 2231680 Positive_regulation TLR7 PFN2 23735002 2231681 Positive_regulation TLR7 PFN3 23735002 2231675 Positive_regulation TLR7 PFN4 23735002 2231676 Positive_regulation TLR7 PHKA2 18947379 111744 Positive_regulation TLR7 PIK3CA 20953381 1748470 Positive_regulation TLR7 PIK3CA 20953381 1748471 Positive_regulation TLR7 PIK3CA 22570785 1688318 Positive_regulation TLR7 PIK3CA 22570785 1688474 Positive_regulation TLR7 PIK3CA 23508732 906397 Positive_regulation TLR7 PIK3CA 24740015 2953798 Positive_regulation TLR7 PIK3CA 24936377 212457 Positive_regulation TLR7 PIK3CA 24936377 212497 Positive_regulation TLR7 PIK3CA 25228903 914102 Positive_regulation TLR7 PIK3R1 20953381 1748472 Positive_regulation TLR7 PIK3R1 20953381 1748473 Positive_regulation TLR7 PIK3R1 22570785 1688319 Positive_regulation TLR7 PIK3R1 22570785 1688475 Positive_regulation TLR7 PIK3R1 23508732 906398 Positive_regulation TLR7 PIK3R1 24740015 2953799 Positive_regulation TLR7 PIK3R1 24936377 212458 Positive_regulation TLR7 PIK3R1 24936377 212498 Positive_regulation TLR7 PIK3R1 25228903 914103 Positive_regulation TLR7 PIKFYVE 24040108 2845730 Positive_regulation TLR7 PIN1 21743479 1955532 Positive_regulation TLR7 PKD1 22783258 902447 Positive_regulation TLR7 PKD1 22928050 2681827 Positive_regulation TLR7 PKD1 25000413 2986842 Positive_regulation TLR7 PLIN2 24718259 2950511 Positive_regulation TLR7 PLXNA4 21098092 1561811 Positive_regulation TLR7 PLXNA4 21098092 1561812 Positive_regulation TLR7 POLDIP2 19543526 2419805 Positive_regulation TLR7 POT1 25118589 1944934 Positive_regulation TLR7 PRDM1 21991317 2561362 Positive_regulation TLR7 PRR11 24356325 607960 Positive_regulation TLR7 PRR12 24356325 607966 Positive_regulation TLR7 PRR13 24356325 607959 Positive_regulation TLR7 PRR14 24356325 607964 Positive_regulation TLR7 PRR15 24356325 607958 Positive_regulation TLR7 PRR16 24356325 607967 Positive_regulation TLR7 PRR18 24356325 607965 Positive_regulation TLR7 PRR19 24356325 607971 Positive_regulation TLR7 PRR21 24356325 607972 Positive_regulation TLR7 PRR22 24356325 607963 Positive_regulation TLR7 PRR24 24356325 607961 Positive_regulation TLR7 PRR25 24356325 607973 Positive_regulation TLR7 PRR26 24356325 607968 Positive_regulation TLR7 PRR3 24356325 607957 Positive_regulation TLR7 PRR4 24356325 607956 Positive_regulation TLR7 PRR5 24356325 607969 Positive_regulation TLR7 PRR7 24356325 607962 Positive_regulation TLR7 PRR9 24356325 607970 Positive_regulation TLR7 PTBP1 15795237 1535225 Positive_regulation TLR7 PTBP1 17296788 1544409 Positive_regulation TLR7 PTBP1 17954572 1547355 Positive_regulation TLR7 PTBP1 17954572 1547363 Positive_regulation TLR7 PTBP1 19204112 1553976 Positive_regulation TLR7 PTBP1 19476613 113407 Positive_regulation TLR7 PTBP1 20027279 3228906 Positive_regulation TLR7 PTBP1 20032970 1917765 Positive_regulation TLR7 PTBP1 21350488 1987037 Positive_regulation TLR7 PTBP1 21555485 1563753 Positive_regulation TLR7 PTBP1 23435233 3222244 Positive_regulation TLR7 PTBP1 23593527 2371851 Positive_regulation TLR7 PTBP1 23630623 2785331 Positive_regulation TLR7 PTBP1 23691339 1151706 Positive_regulation TLR7 PTBP1 23781253 637826 Positive_regulation TLR7 PTBP1 24598455 132022 Positive_regulation TLR7 PTBP2 15795237 1535222 Positive_regulation TLR7 PTBP2 17296788 1544406 Positive_regulation TLR7 PTBP2 17954572 1547352 Positive_regulation TLR7 PTBP2 17954572 1547360 Positive_regulation TLR7 PTBP2 19204112 1553973 Positive_regulation TLR7 PTBP2 19476613 113404 Positive_regulation TLR7 PTBP2 20027279 3228903 Positive_regulation TLR7 PTBP2 20032970 1917762 Positive_regulation TLR7 PTBP2 21350488 1987034 Positive_regulation TLR7 PTBP2 21555485 1563750 Positive_regulation TLR7 PTBP2 23435233 3222240 Positive_regulation TLR7 PTBP2 23593527 2371848 Positive_regulation TLR7 PTBP2 23630623 2785328 Positive_regulation TLR7 PTBP2 23691339 1151703 Positive_regulation TLR7 PTBP2 23781253 637823 Positive_regulation TLR7 PTBP2 24598455 132019 Positive_regulation TLR7 PTGS2 21127710 1748671 Positive_regulation TLR7 PTGS2 25309919 201162 Positive_regulation TLR7 PTGS2 25549244 3036805 Positive_regulation TLR7 PVR 23349877 2743845 Positive_regulation TLR7 RABEPK 19703985 1555899 Positive_regulation TLR7 RABEPK 23162549 904996 Positive_regulation TLR7 RAC1 20231379 1557725 Positive_regulation TLR7 RAC1 21098092 1561813 Positive_regulation TLR7 RAC2 20231379 1557726 Positive_regulation TLR7 RAC2 21098092 1561814 Positive_regulation TLR7 RAC3 20231379 1557727 Positive_regulation TLR7 RAC3 21098092 1561815 Positive_regulation TLR7 RAD50 25118589 1944099 Positive_regulation TLR7 RAD50 25118589 1944937 Positive_regulation TLR7 RASGRP1 25118589 1943918 Positive_regulation TLR7 RASGRP3 25118589 1944094 Positive_regulation TLR7 RBPJ 22610140 1957412 Positive_regulation TLR7 RELA 20808962 2473192 Positive_regulation TLR7 RELA 21044333 659699 Positive_regulation TLR7 RELA 21451502 1918299 Positive_regulation TLR7 RELA 22566904 899775 Positive_regulation TLR7 RICTOR 24740015 2953963 Positive_regulation TLR7 RICTOR 24740015 2954460 Positive_regulation TLR7 RNF19A 21064192 775617 Positive_regulation TLR7 RNF19A 22253793 2587922 Positive_regulation TLR7 RNF19A 22253793 2587969 Positive_regulation TLR7 RNF216 22737610 2161036 Positive_regulation TLR7 RNF216 23109936 968843 Positive_regulation TLR7 RPL36 19451267 1554836 Positive_regulation TLR7 RSAD2 23435233 3222221 Positive_regulation TLR7 RSAD2 24178712 3223559 Positive_regulation TLR7 SEMA3A 21098092 1561908 Positive_regulation TLR7 SEMA3A 21098092 1561954 Positive_regulation TLR7 SEMA3A 21098092 1561955 Positive_regulation TLR7 SETD2 21516132 12702 Positive_regulation TLR7 SETD2 24409099 2285251 Positive_regulation TLR7 SETD2 PMC4088757 661300 Positive_regulation TLR7 SIGIRR 22661952 957333 Positive_regulation TLR7 SIGLEC1 23593001 3060659 Positive_regulation TLR7 SMN1 24228757 1641126 Positive_regulation TLR7 SNRNP70 16330816 1538740 Positive_regulation TLR7 SNRNP70 16330816 1538743 Positive_regulation TLR7 SNRNP70 16330816 1538750 Positive_regulation TLR7 SNRPA 16330816 1538741 Positive_regulation TLR7 SNRPA 16330816 1538744 Positive_regulation TLR7 SNRPA 16330816 1538751 Positive_regulation TLR7 SNRPC 16330816 1538742 Positive_regulation TLR7 SNRPC 16330816 1538745 Positive_regulation TLR7 SNRPC 16330816 1538752 Positive_regulation TLR7 SOCS1 16381597 2368677 Positive_regulation TLR7 SOCS1 19300567 2011611 Positive_regulation TLR7 SOCS1 20859626 488097 Positive_regulation TLR7 SOCS1 20862390 979465 Positive_regulation TLR7 SOCS1 20862390 979515 Positive_regulation TLR7 SOCS1 20862390 979516 Positive_regulation TLR7 SOCS1 20862390 979565 Positive_regulation TLR7 SOCS1 21789039 979902 Positive_regulation TLR7 SOCS1 22566885 899557 Positive_regulation TLR7 SOCS1 22727118 1663626 Positive_regulation TLR7 SOCS1 23505488 2766245 Positive_regulation TLR7 SOCS1 24757565 1831877 Positive_regulation TLR7 SOCS2 19779605 2427232 Positive_regulation TLR7 SOCS2 22291912 2591096 Positive_regulation TLR7 SOCS2 22291912 2591097 Positive_regulation TLR7 SOCS2 22291912 2591098 Positive_regulation TLR7 SOCS2 22291912 2591181 Positive_regulation TLR7 SOCS2 24489947 2917094 Positive_regulation TLR7 SOCS3 20862390 979466 Positive_regulation TLR7 SOCS3 22566885 899558 Positive_regulation TLR7 SOCS3 25120543 913733 Positive_regulation TLR7 SPP1 23508732 906391 Positive_regulation TLR7 ST2 22661952 957331 Positive_regulation TLR7 STAT1 23295066 1733899 Positive_regulation TLR7 STAT1 23593264 2780475 Positive_regulation TLR7 STAT1 23593264 2780485 Positive_regulation TLR7 SYK 18947379 111742 Positive_regulation TLR7 SYK 24286216 130799 Positive_regulation TLR7 SYK 24286216 130831 Positive_regulation TLR7 TAB2 21625535 3051877 Positive_regulation TLR7 TAB2 23799152 2807296 Positive_regulation TLR7 TANK 19668221 1952808 Positive_regulation TLR7 TBK1 21904615 2550474 Positive_regulation TLR7 TCF12 23320062 2739297 Positive_regulation TLR7 TCF15 23320062 2739298 Positive_regulation TLR7 TCF19 23320062 2739299 Positive_regulation TLR7 TCF20 23320062 2739300 Positive_regulation TLR7 TCF21 23320062 2739301 Positive_regulation TLR7 TCF23 23320062 2739305 Positive_regulation TLR7 TCF24 23320062 2739307 Positive_regulation TLR7 TCF25 23320062 2739306 Positive_regulation TLR7 TCF3 23320062 2739302 Positive_regulation TLR7 TCF4 23320062 2739303 Positive_regulation TLR7 TCF7 23320062 2739304 Positive_regulation TLR7 TDGF1P3 23133361 2297631 Positive_regulation TLR7 TERF1 25118589 1944931 Positive_regulation TLR7 TERF2 25118589 1944092 Positive_regulation TLR7 TERF2 25118589 1944932 Positive_regulation TLR7 TERF2IP 25118589 1944095 Positive_regulation TLR7 TERF2IP 25118589 1944935 Positive_regulation TLR7 TFAP4 23426999 748721 Positive_regulation TLR7 THEMIS2 20644716 2455949 Positive_regulation TLR7 TINF2 25118589 1944933 Positive_regulation TLR7 TIRAP 19229310 2290204 Positive_regulation TLR7 TLR1 17664289 1546753 Positive_regulation TLR7 TLR1 19686596 3118114 Positive_regulation TLR7 TLR10 17664289 1546763 Positive_regulation TLR7 TLR10 19686596 3118122 Positive_regulation TLR7 TLR2 17664289 1546754 Positive_regulation TLR7 TLR2 19686596 3118115 Positive_regulation TLR7 TLR2 20098705 2437917 Positive_regulation TLR7 TLR2 22802904 2219188 Positive_regulation TLR7 TLR2 23840549 2815158 Positive_regulation TLR7 TLR2 24690917 2947300 Positive_regulation TLR7 TLR2 24904576 912944 Positive_regulation TLR7 TLR2 24936377 212435 Positive_regulation TLR7 TLR2 25002964 651806 Positive_regulation TLR7 TLR3 17664289 1546755 Positive_regulation TLR7 TLR3 19686596 3118116 Positive_regulation TLR7 TLR3 22761938 2659366 Positive_regulation TLR7 TLR3 23061052 863697 Positive_regulation TLR7 TLR3 23787776 3222819 Positive_regulation TLR7 TLR3 25071732 927126 Positive_regulation TLR7 TLR3 25309919 201091 Positive_regulation TLR7 TLR4 17664289 1546756 Positive_regulation TLR7 TLR4 19686596 3118117 Positive_regulation TLR7 TLR4 20098705 2437918 Positive_regulation TLR7 TLR4 23358229 2744790 Positive_regulation TLR7 TLR4 24031722 454287 Positive_regulation TLR7 TLR4 25580138 1703350 Positive_regulation TLR7 TLR5 17664289 1546757 Positive_regulation TLR7 TLR5 19686596 3118118 Positive_regulation TLR7 TLR6 17664289 1546764 Positive_regulation TLR7 TLR6 19686596 3118123 Positive_regulation TLR7 TLR7 17664289 1546760 Positive_regulation TLR7 TLR7 19686596 3118119 Positive_regulation TLR7 TLR8 17664289 1546761 Positive_regulation TLR7 TLR8 19686596 3118120 Positive_regulation TLR7 TLR8 23085951 596481 Positive_regulation TLR7 TLR8 23281837 127633 Positive_regulation TLR7 TLR8 24904837 865233 Positive_regulation TLR7 TLR9 17664289 1546762 Positive_regulation TLR7 TLR9 18652679 352344 Positive_regulation TLR7 TLR9 19183807 2405096 Positive_regulation TLR7 TLR9 19686596 3118121 Positive_regulation TLR7 TLR9 21623603 3232825 Positive_regulation TLR7 TLR9 22238604 2586634 Positive_regulation TLR7 TLR9 22761938 2659367 Positive_regulation TLR7 TLR9 23396449 2085552 Positive_regulation TLR7 TLR9 23396449 2085555 Positive_regulation TLR7 TLR9 25484888 971879 Positive_regulation TLR7 TNF 18227218 1548835 Positive_regulation TLR7 TNF 19183807 2405095 Positive_regulation TLR7 TNF 19419540 3117788 Positive_regulation TLR7 TNF 21556316 1078209 Positive_regulation TLR7 TNF 21915309 2553191 Positive_regulation TLR7 TNF 22691272 126194 Positive_regulation TLR7 TNF 23283295 3225602 Positive_regulation TLR7 TNF 23484125 179640 Positive_regulation TLR7 TNF 23826189 2810745 Positive_regulation TLR7 TNF 24058791 1705786 Positive_regulation TLR7 TNF PMC3007769 1702448 Positive_regulation TLR7 TNF PMC3242235 1702536 Positive_regulation TLR7 TNFAIP3 18268035 1549065 Positive_regulation TLR7 TNFAIP3 18268035 1549270 Positive_regulation TLR7 TNFSF10 25196285 3224143 Positive_regulation TLR7 TNFSF13 20803699 1050203 Positive_regulation TLR7 TNFSF13B 17664289 1546724 Positive_regulation TLR7 TNFSF13B 17664289 1546725 Positive_regulation TLR7 TNFSF13B 17664289 1546732 Positive_regulation TLR7 TNFSF13B 17664289 1546733 Positive_regulation TLR7 TNFSF13B 17664289 1546758 Positive_regulation TLR7 TNFSF13B 17664289 1546759 Positive_regulation TLR7 TNFSF13B 21785618 633088 Positive_regulation TLR7 TNFSF13B 23940791 2832484 Positive_regulation TLR7 TNFSF13B 25076492 2993381 Positive_regulation TLR7 TNFSF13B 25076492 2993382 Positive_regulation TLR7 TNFSF15 20980995 1918018 Positive_regulation TLR7 TNFSF15 24453414 1756707 Positive_regulation TLR7 TOLLIP 23497067 366980 Positive_regulation TLR7 TP53 21483755 2323135 Positive_regulation TLR7 TP53 21483755 2323175 Positive_regulation TLR7 TP53 21483755 2323176 Positive_regulation TLR7 TP53 21483755 2323201 Positive_regulation TLR7 TRAF3 23508732 906392 Positive_regulation TLR7 TRAF3 25161655 913934 Positive_regulation TLR7 TRAF6 20497537 362655 Positive_regulation TLR7 TRAF6 21625535 3051875 Positive_regulation TLR7 TRAF6 23514422 1683665 Positive_regulation TLR7 TRAF6 23799152 2807293 Positive_regulation TLR7 TRAF6 24252328 178842 Positive_regulation TLR7 TRAF6 25161655 913935 Positive_regulation TLR7 TRAM1 21203418 2489956 Positive_regulation TLR7 TRAM1 23078795 1617306 Positive_regulation TLR7 TRAM2 21203418 2489955 Positive_regulation TLR7 TRAM2 23078795 1617305 Positive_regulation TLR7 TRAT1 23429360 838498 Positive_regulation TLR7 TRIM21 22479513 2615666 Positive_regulation TLR7 TRIM21 22701487 1144890 Positive_regulation TLR7 TRIM21 22701487 1144915 Positive_regulation TLR7 TRIM21 23304190 637156 Positive_regulation TLR7 TRIP10 22945920 1568919 Positive_regulation TLR7 TRIP10 22945920 1569149 Positive_regulation TLR7 TRIP11 22945920 1568920 Positive_regulation TLR7 TRIP11 22945920 1569150 Positive_regulation TLR7 TRIP12 22945920 1568921 Positive_regulation TLR7 TRIP12 22945920 1569151 Positive_regulation TLR7 TRIP13 22945920 1568922 Positive_regulation TLR7 TRIP13 22945920 1569152 Positive_regulation TLR7 TRIP4 22945920 1568923 Positive_regulation TLR7 TRIP4 22945920 1569153 Positive_regulation TLR7 TRIP6 22945920 1568924 Positive_regulation TLR7 TRIP6 22945920 1569154 Positive_regulation TLR7 TSLP 24335833 1736592 Positive_regulation TLR7 UBE2V1 21625535 3051876 Positive_regulation TLR7 UBE2V1 23799152 2807294 Positive_regulation TLR7 UMOD PMC3760629 1606004 Positive_regulation TLR7 UNC93B1 17452530 1339531 Positive_regulation TLR7 UNC93B1 17452530 1339820 Positive_regulation TLR7 UNC93B1 19451267 1554834 Positive_regulation TLR7 UNC93B1 19451267 1554835 Positive_regulation TLR7 UNC93B1 23103873 1989156 Positive_regulation TLR7 UNC93B1 23426999 748722 Positive_regulation TLR7 UNC93B1 23426999 748761 Positive_regulation TLR7 UNC93B1 23426999 748762 Positive_regulation TLR7 UNC93B1 23908972 864173 Positive_regulation TLR7 UNC93B1 25309543 914372 Positive_regulation TLR7 UNC93B2 17452530 1339532 Positive_regulation TLR7 UNC93B2 17452530 1339821 Positive_regulation TLR7 UNC93B2 23103873 1989157 Positive_regulation TLR7 UNC93B3 17452530 1339533 Positive_regulation TLR7 UNC93B3 17452530 1339822 Positive_regulation TLR7 UNC93B3 23103873 1989158 Positive_regulation TLR7 UNC93B4 17452530 1339534 Positive_regulation TLR7 UNC93B4 17452530 1339823 Positive_regulation TLR7 UNC93B4 23103873 1989159 Positive_regulation TLR7 UNC93B5 17452530 1339535 Positive_regulation TLR7 UNC93B5 17452530 1339824 Positive_regulation TLR7 UNC93B5 23103873 1989160 Positive_regulation TLR7 UNC93B6 17452530 1339536 Positive_regulation TLR7 UNC93B6 17452530 1339825 Positive_regulation TLR7 UNC93B6 23103873 1989161 Positive_regulation TLR7 UNC93B7 17452530 1339537 Positive_regulation TLR7 UNC93B7 17452530 1339826 Positive_regulation TLR7 UNC93B7 23103873 1989162 Positive_regulation TLR7 UNC93B8 17452530 1339538 Positive_regulation TLR7 UNC93B8 17452530 1339827 Positive_regulation TLR7 UNC93B8 23103873 1989163 Positive_regulation TLR7 WNK1 22570745 1024101 Positive_regulation TLR7 WWP1 23799152 2807295 Positive_regulation TLR7 XBP1 24286299 131019 Positive_regulation TLR7 XBP1 24387801 1162633 Positive_regulation TLR7 XBP1 24904537 926738 Positive_regulation TLR7 XBP1 25530974 1496813 Positive_regulation TLR7 XRCC5 25118589 1944093 Positive_regulation TLR7 XRCC6 25118589 1944097 Positive_regulation TLR7 YME1L1 16827942 3107325 Positive_regulation TLR7 YME1L1 21483755 2323136 Positive_regulation TLR7 YME1L1 25431758 948884 Positive_regulation TLR7 YME1L1 25595212 3211351 Positive_regulation TLR8 CD14 20236452 659502 Positive_regulation TLR8 CD14 21078886 1561468 Positive_regulation TLR8 CD14 21789185 2537954 Positive_regulation TLR8 CD14 PMC3109490 927535 Positive_regulation TLR8 CYP24A1 21124742 2484011 Positive_regulation TLR8 EPHB2 22253793 2587972 Positive_regulation TLR8 EPHB2 22783258 902294 Positive_regulation TLR8 EPHB2 24927726 1684597 Positive_regulation TLR8 IL1B 23936458 2830971 Positive_regulation TLR8 IL1B 24060373 1700525 Positive_regulation TLR8 MMP28 18762577 1355735 Positive_regulation TLR8 MMP28 18762577 1355736 Positive_regulation TLR8 MMP28 18762577 1355737 Positive_regulation TLR8 MMP7 18762577 1355780 Positive_regulation TLR8 MMP7 18762577 1355781 Positive_regulation TLR8 MMP7 18762577 1355782 Positive_regulation TLR8 MUC16 24527027 980846 Positive_regulation TLR8 TLR7 17893200 1547130 Positive_regulation TLR8 TLR7 19591639 116079 Positive_regulation TLR8 TLR7 19686596 3118124 Positive_regulation TLR8 TNF 18227218 1548840 Positive_regulation TLR8 TNF 19183807 2405098 Positive_regulation TLR8 TNF 19419540 3117789 Positive_regulation TLR8 TNF 20946625 3111374 Positive_regulation TLR8 TNF 21203477 3050259 Positive_regulation TLR8 TNF 21915309 2553192 Positive_regulation TLR8 TNF 22691272 126222 Positive_regulation TLR8 TNF 23283295 3225604 Positive_regulation TLR8 TNF 23484125 179642 Positive_regulation TLR8 TNF 24058791 1705789 Positive_regulation TLR8 TNF 24474949 910925 Positive_regulation TLR8 TNF PMC3007769 1702450 Positive_regulation TLR8 TNF PMC3242235 1702538 Positive_regulation TLR8 TNFSF10 25196285 3224144 Positive_regulation TLR9 ADRB2 23724117 2799035 Positive_regulation TLR9 CD14 20236452 659503 Positive_regulation TLR9 CD14 21078886 1561469 Positive_regulation TLR9 CD14 21789185 2537955 Positive_regulation TLR9 CD14 PMC3109490 927536 Positive_regulation TLR9 CD22 22566885 899542 Positive_regulation TLR9 CYP24A1 21124742 2484012 Positive_regulation TLR9 EPHB2 19667062 1555669 Positive_regulation TLR9 EPHB2 19667062 1555670 Positive_regulation TLR9 EPHB2 22253793 2587974 Positive_regulation TLR9 EPHB2 22783258 902296 Positive_regulation TLR9 EPHB2 24927726 1684599 Positive_regulation TLR9 IL1B 23936458 2830972 Positive_regulation TLR9 IL1B 24060373 1700526 Positive_regulation TLR9 MMP28 18762577 1355801 Positive_regulation TLR9 MMP28 18762577 1355802 Positive_regulation TLR9 MMP28 18762577 1355803 Positive_regulation TLR9 MMP7 18762577 1355846 Positive_regulation TLR9 MMP7 18762577 1355847 Positive_regulation TLR9 MMP7 18762577 1355848 Positive_regulation TLR9 MUC16 24527027 980861 Positive_regulation TLR9 TLR7 19183807 2405101 Positive_regulation TLR9 TLR7 19686596 3118125 Positive_regulation TLR9 TLR7 20051129 3110218 Positive_regulation TLR9 TLR7 21743479 1955534 Positive_regulation TLR9 TLR7 21743479 1955569 Positive_regulation TLR9 TLR7 22078750 124389 Positive_regulation TLR9 TLR7 22238604 2586641 Positive_regulation TLR9 TLR7 22566959 900487 Positive_regulation TLR9 TLR7 22919688 863613 Positive_regulation TLR9 TLR7 24489644 2915551 Positive_regulation TLR9 TLR7 24489947 2917032 Positive_regulation TLR9 TLR7 25484888 971881 Positive_regulation TLR9 TLR7 PMC3442082 3125552 Positive_regulation TLR9 TNF 15631627 3104188 Positive_regulation TLR9 TNF 18227218 1548845 Positive_regulation TLR9 TNF 19183807 2405100 Positive_regulation TLR9 TNF 19419540 3117790 Positive_regulation TLR9 TNF 19476613 113409 Positive_regulation TLR9 TNF 20145703 1213511 Positive_regulation TLR9 TNF 20525148 34497 Positive_regulation TLR9 TNF 21915309 2553193 Positive_regulation TLR9 TNF 22666624 1052873 Positive_regulation TLR9 TNF 23283295 3225606 Positive_regulation TLR9 TNF 23484125 179644 Positive_regulation TLR9 TNF 23851335 1024540 Positive_regulation TLR9 TNF 24058791 1705792 Positive_regulation TLR9 TNF 24083053 3175368 Positive_regulation TLR9 TNF PMC3007769 1702452 Positive_regulation TLR9 TNF PMC3242235 1702540 Positive_regulation TLR9 TNFSF10 25196285 3224145 Positive_regulation TMED2 TNF 19568431 2420571 Positive_regulation TMED7 CCND1 11259090 418394 Positive_regulation TMED7 CCND1 21209944 2492501 Positive_regulation TMED7 CCND1 23511556 440342 Positive_regulation TMED7 FOXO1 21209944 2492508 Positive_regulation TMED7 FOXO1 23614736 830005 Positive_regulation TMED7 FOXO1 23630664 943084 Positive_regulation TMED7 ID1 20003244 254758 Positive_regulation TMED7 ID1 23342268 491934 Positive_regulation TMED7 IFI27 18477650 505697 Positive_regulation TMED7 IFI27 19149897 401631 Positive_regulation TMED7 IFI27 20200561 1719457 Positive_regulation TMED7 IFI27 21566658 547253 Positive_regulation TMED7 IFI27 22558406 2625559 Positive_regulation TMED7 IFI27 23029392 2697137 Positive_regulation TMED7 IFI27 24056538 3137229 Positive_regulation TMED7 MAP2K6 20838657 2272416 Positive_regulation TMED7 S100A7 20955608 585863 Positive_regulation TMED7 UCA1 24457952 571257 Positive_regulation TMED7 UCA1 24457952 571304 Positive_regulation TMED7 UCA1 24457952 571311 Positive_regulation TMED9 CAPN8 21278733 1966551 Positive_regulation TMED9 CAPN8 23056393 2701476 Positive_regulation TMEM100 APP 24404197 2906427 Positive_regulation TMEM100 ATF6 23629671 1106225 Positive_regulation TMEM100 BCL10 24790593 681082 Positive_regulation TMEM100 BCL2 24790593 681083 Positive_regulation TMEM100 BCL3 24790593 681084 Positive_regulation TMEM100 BCL5 24790593 681079 Positive_regulation TMEM100 BCL6 24790593 681080 Positive_regulation TMEM100 BCL9 24790593 681081 Positive_regulation TMEM100 BDKRB2 24277599 1610769 Positive_regulation TMEM100 CSF1 22479615 2616431 Positive_regulation TMEM100 ERBB2 21443808 397747 Positive_regulation TMEM100 ERBB2 25137062 2999678 Positive_regulation TMEM100 F2RL1 24277599 1610770 Positive_regulation TMEM100 GDF2 24670474 1125660 Positive_regulation TMEM100 GH1 22500953 355488 Positive_regulation TMEM100 MYLIP 24098708 2859173 Positive_regulation TMEM100 NFATC1 23509596 817598 Positive_regulation TMEM100 NOTCH1 22679484 2649614 Positive_regulation TMEM100 NOTCH1 24395635 1414100 Positive_regulation TMEM100 NOTCH2 22679484 2649615 Positive_regulation TMEM100 NOTCH2 24395635 1414101 Positive_regulation TMEM100 NOTCH3 22679484 2649616 Positive_regulation TMEM100 NOTCH3 24395635 1414102 Positive_regulation TMEM100 NOTCH4 22679484 2649617 Positive_regulation TMEM100 NOTCH4 24395635 1414103 Positive_regulation TMEM100 PLXNB1 25137062 2999679 Positive_regulation TMEM100 PTCH1 24393163 1871116 Positive_regulation TMEM100 TNF 22479555 2616012 Positive_regulation TMEM100 TNF 23766697 3154809 Positive_regulation TMEM100 TNFSF11 22479615 2616430 Positive_regulation TMEM100 TNFSF11 24558484 2923774 Positive_regulation TMEM100 TNFSF11 25489576 1236446 Positive_regulation TMEM100 TPT1 24465583 2911059 Positive_regulation TMEM100 TRIM3 19582228 1088612 Positive_regulation TMEM100 VEGFA 20616955 2120522 Positive_regulation TMEM100 XBP1 24705207 985240 Positive_regulation TMEM101 TNF 22479555 2616078 Positive_regulation TMEM101 TNF 23766697 3154875 Positive_regulation TMEM102 TNF 22479555 2616041 Positive_regulation TMEM102 TNF 23766697 3154838 Positive_regulation TMEM104 TNF 22479555 2616021 Positive_regulation TMEM104 TNF 23766697 3154818 Positive_regulation TMEM105 TNF 22479555 2616043 Positive_regulation TMEM105 TNF 23766697 3154840 Positive_regulation TMEM107 TNF 22479555 2616058 Positive_regulation TMEM107 TNF 23766697 3154855 Positive_regulation TMEM108 TNF 22479555 2616071 Positive_regulation TMEM108 TNF 23766697 3154868 Positive_regulation TMEM109 TNF 22479555 2616080 Positive_regulation TMEM109 TNF 23766697 3154877 Positive_regulation TMEM11 TNF 22479555 2615964 Positive_regulation TMEM11 TNF 23766697 3154761 Positive_regulation TMEM110 TNF 22479555 2616092 Positive_regulation TMEM110 TNF 23766697 3154889 Positive_regulation TMEM114 TNF 22479555 2616106 Positive_regulation TMEM114 TNF 23766697 3154903 Positive_regulation TMEM115 TNF 22479555 2616086 Positive_regulation TMEM115 TNF 23766697 3154883 Positive_regulation TMEM116 TNF 22479555 2615992 Positive_regulation TMEM116 TNF 23766697 3154789 Positive_regulation TMEM117 TNF 22479555 2616000 Positive_regulation TMEM117 TNF 23766697 3154797 Positive_regulation TMEM119 TNF 22479555 2616052 Positive_regulation TMEM119 TNF 23766697 3154849 Positive_regulation TMEM121 TNF 22479555 2615974 Positive_regulation TMEM121 TNF 23766697 3154771 Positive_regulation TMEM123 TNF 22479555 2616088 Positive_regulation TMEM123 TNF 23766697 3154885 Positive_regulation TMEM125 TNF 22479555 2616066 Positive_regulation TMEM125 TNF 23766697 3154863 Positive_regulation TMEM127 TNF 22479555 2616022 Positive_regulation TMEM127 TNF 23766697 3154819 Positive_regulation TMEM128 TNF 22479555 2616063 Positive_regulation TMEM128 TNF 23766697 3154860 Positive_regulation TMEM129 TNF 22479555 2615995 Positive_regulation TMEM129 TNF 23766697 3154792 Positive_regulation TMEM130 TNF 22479555 2616003 Positive_regulation TMEM130 TNF 23766697 3154800 Positive_regulation TMEM131 TNF 22479555 2616090 Positive_regulation TMEM131 TNF 23766697 3154887 Positive_regulation TMEM133 TNF 22479555 2615986 Positive_regulation TMEM133 TNF 23766697 3154783 Positive_regulation TMEM134 TNF 22479555 2616025 Positive_regulation TMEM134 TNF 23766697 3154822 Positive_regulation TMEM135 TNF 22479555 2616026 Positive_regulation TMEM135 TNF 23766697 3154823 Positive_regulation TMEM136 TNF 22479555 2616067 Positive_regulation TMEM136 TNF 23766697 3154864 Positive_regulation TMEM138 TNF 22479555 2616045 Positive_regulation TMEM138 TNF 23766697 3154842 Positive_regulation TMEM139 TNF 22479555 2615983 Positive_regulation TMEM139 TNF 23766697 3154780 Positive_regulation TMEM140 TNF 22479555 2615980 Positive_regulation TMEM140 TNF 23766697 3154777 Positive_regulation TMEM141 TNF 22479555 2616064 Positive_regulation TMEM141 TNF 23766697 3154861 Positive_regulation TMEM143 TNF 22479555 2616010 Positive_regulation TMEM143 TNF 23766697 3154807 Positive_regulation TMEM144 TNF 22479555 2616015 Positive_regulation TMEM144 TNF 23766697 3154812 Positive_regulation TMEM145 TNF 22479555 2616044 Positive_regulation TMEM145 TNF 23766697 3154841 Positive_regulation TMEM147 TNF 22479555 2616091 Positive_regulation TMEM147 TNF 23766697 3154888 Positive_regulation TMEM154 TNF 22479555 2616036 Positive_regulation TMEM154 TNF 23766697 3154833 Positive_regulation TMEM155 TNF 22479555 2616034 Positive_regulation TMEM155 TNF 23766697 3154831 Positive_regulation TMEM156 APP 24404197 2906445 Positive_regulation TMEM156 ATF6 23629671 1106243 Positive_regulation TMEM156 BCL10 24790593 681190 Positive_regulation TMEM156 BCL2 24790593 681191 Positive_regulation TMEM156 BCL3 24790593 681192 Positive_regulation TMEM156 BCL5 24790593 681187 Positive_regulation TMEM156 BCL6 24790593 681188 Positive_regulation TMEM156 BCL9 24790593 681189 Positive_regulation TMEM156 BDKRB2 24277599 1610805 Positive_regulation TMEM156 CSF1 22479615 2616467 Positive_regulation TMEM156 ERBB2 21443808 397765 Positive_regulation TMEM156 ERBB2 25137062 2999714 Positive_regulation TMEM156 F2RL1 24277599 1610806 Positive_regulation TMEM156 GH1 22500953 355506 Positive_regulation TMEM156 MYLIP 24098708 2859191 Positive_regulation TMEM156 NFATC1 23509596 817616 Positive_regulation TMEM156 NOTCH1 22679484 2649686 Positive_regulation TMEM156 NOTCH1 24395635 1414172 Positive_regulation TMEM156 NOTCH2 22679484 2649687 Positive_regulation TMEM156 NOTCH2 24395635 1414173 Positive_regulation TMEM156 NOTCH3 22679484 2649688 Positive_regulation TMEM156 NOTCH3 24395635 1414174 Positive_regulation TMEM156 NOTCH4 22679484 2649689 Positive_regulation TMEM156 NOTCH4 24395635 1414175 Positive_regulation TMEM156 PLXNB1 25137062 2999715 Positive_regulation TMEM156 PTCH1 24393163 1871134 Positive_regulation TMEM156 TNF 22479555 2616030 Positive_regulation TMEM156 TNF 23766697 3154827 Positive_regulation TMEM156 TNFSF11 22479615 2616466 Positive_regulation TMEM156 TNFSF11 24558484 2923792 Positive_regulation TMEM156 TNFSF11 25489576 1236464 Positive_regulation TMEM156 TPT1 24465583 2911077 Positive_regulation TMEM156 TRIM3 19582228 1088630 Positive_regulation TMEM156 VEGFA 20616955 2120540 Positive_regulation TMEM156 XBP1 24705207 985258 Positive_regulation TMEM158 TNF 22479555 2616089 Positive_regulation TMEM158 TNF 23766697 3154886 Positive_regulation TMEM159 TNF 22479555 2616087 Positive_regulation TMEM159 TNF 23766697 3154884 Positive_regulation TMEM160 TNF 22479555 2616023 Positive_regulation TMEM160 TNF 23766697 3154820 Positive_regulation TMEM163 TNF 22479555 2616002 Positive_regulation TMEM163 TNF 23766697 3154799 Positive_regulation TMEM164 TNF 22479555 2616029 Positive_regulation TMEM164 TNF 23766697 3154826 Positive_regulation TMEM165 TNF 22479555 2616094 Positive_regulation TMEM165 TNF 23766697 3154891 Positive_regulation TMEM168 TNF 22479555 2616017 Positive_regulation TMEM168 TNF 23766697 3154814 Positive_regulation TMEM169 TNF 22479555 2615994 Positive_regulation TMEM169 TNF 23766697 3154791 Positive_regulation TMEM17 TNF 22479555 2616040 Positive_regulation TMEM17 TNF 23766697 3154837 Positive_regulation TMEM171 TNF 22479555 2616046 Positive_regulation TMEM171 TNF 23766697 3154843 Positive_regulation TMEM173 TNF 22479555 2616055 Positive_regulation TMEM173 TNF 23766697 3154852 Positive_regulation TMEM174 TNF 22479555 2616061 Positive_regulation TMEM174 TNF 23766697 3154858 Positive_regulation TMEM175 TNF 22479555 2616079 Positive_regulation TMEM175 TNF 23766697 3154876 Positive_regulation TMEM177 TNF 22479555 2616059 Positive_regulation TMEM177 TNF 23766697 3154856 Positive_regulation TMEM179 TNF 22479555 2615971 Positive_regulation TMEM179 TNF 23766697 3154768 Positive_regulation TMEM18 TNF 22479555 2615999 Positive_regulation TMEM18 TNF 23766697 3154796 Positive_regulation TMEM180 TNF 22479555 2616028 Positive_regulation TMEM180 TNF 23766697 3154825 Positive_regulation TMEM181 TNF 22479555 2615975 Positive_regulation TMEM181 TNF 23766697 3154772 Positive_regulation TMEM182 TNF 22479555 2616032 Positive_regulation TMEM182 TNF 23766697 3154829 Positive_regulation TMEM182 TNF 24903457 361410 Positive_regulation TMEM186 TNF 22479555 2615989 Positive_regulation TMEM186 TNF 23766697 3154786 Positive_regulation TMEM187 TNF 22479555 2615959 Positive_regulation TMEM187 TNF 23766697 3154756 Positive_regulation TMEM189 TNF 22479555 2615963 Positive_regulation TMEM189 TNF 23766697 3154760 Positive_regulation TMEM19 TNF 22479555 2616011 Positive_regulation TMEM19 TNF 23766697 3154808 Positive_regulation TMEM190 TNF 22479555 2616085 Positive_regulation TMEM190 TNF 23766697 3154882 Positive_regulation TMEM192 TNF 22479555 2616042 Positive_regulation TMEM192 TNF 23766697 3154839 Positive_regulation TMEM196 TNF 22479555 2615984 Positive_regulation TMEM196 TNF 23766697 3154781 Positive_regulation TMEM198 TNF 22479555 2616107 Positive_regulation TMEM198 TNF 23766697 3154904 Positive_regulation TMEM199 TNF 22479555 2615967 Positive_regulation TMEM199 TNF 23766697 3154764 Positive_regulation TMEM2 TNF 22479555 2615955 Positive_regulation TMEM2 TNF 23766697 3154752 Positive_regulation TMEM201 TNF 22479555 2616109 Positive_regulation TMEM201 TNF 23766697 3154906 Positive_regulation TMEM202 TNF 22479555 2616111 Positive_regulation TMEM202 TNF 23766697 3154908 Positive_regulation TMEM203 TNF 22479555 2616065 Positive_regulation TMEM203 TNF 23766697 3154862 Positive_regulation TMEM204 TNF 22479555 2615960 Positive_regulation TMEM204 TNF 23766697 3154757 Positive_regulation TMEM205 TNF 22479555 2616084 Positive_regulation TMEM205 TNF 23766697 3154881 Positive_regulation TMEM206 TNF 22479555 2616009 Positive_regulation TMEM206 TNF 23766697 3154806 Positive_regulation TMEM207 TNF 22479555 2616108 Positive_regulation TMEM207 TNF 23766697 3154905 Positive_regulation TMEM208 TNF 22479555 2615990 Positive_regulation TMEM208 TNF 23766697 3154787 Positive_regulation TMEM209 TNF 22479555 2615981 Positive_regulation TMEM209 TNF 23766697 3154778 Positive_regulation TMEM210 TNF 22479555 2616114 Positive_regulation TMEM210 TNF 23766697 3154911 Positive_regulation TMEM211 APP 24404197 2906525 Positive_regulation TMEM211 ATF6 23629671 1106323 Positive_regulation TMEM211 BCL10 24790593 681670 Positive_regulation TMEM211 BCL2 24790593 681671 Positive_regulation TMEM211 BCL3 24790593 681672 Positive_regulation TMEM211 BCL5 24790593 681667 Positive_regulation TMEM211 BCL6 24790593 681668 Positive_regulation TMEM211 BCL9 24790593 681669 Positive_regulation TMEM211 BDKRB2 24277599 1610965 Positive_regulation TMEM211 CSF1 22479615 2616627 Positive_regulation TMEM211 ERBB2 21443808 397845 Positive_regulation TMEM211 ERBB2 25137062 2999874 Positive_regulation TMEM211 F2RL1 24277599 1610966 Positive_regulation TMEM211 GH1 22500953 355587 Positive_regulation TMEM211 MYLIP 24098708 2859273 Positive_regulation TMEM211 NFATC1 23509596 817696 Positive_regulation TMEM211 NOTCH1 22679484 2650006 Positive_regulation TMEM211 NOTCH1 24395635 1414492 Positive_regulation TMEM211 NOTCH2 22679484 2650007 Positive_regulation TMEM211 NOTCH2 24395635 1414493 Positive_regulation TMEM211 NOTCH3 22679484 2650008 Positive_regulation TMEM211 NOTCH3 24395635 1414494 Positive_regulation TMEM211 NOTCH4 22679484 2650009 Positive_regulation TMEM211 NOTCH4 24395635 1414495 Positive_regulation TMEM211 PLXNB1 25137062 2999875 Positive_regulation TMEM211 PTCH1 24393163 1871214 Positive_regulation TMEM211 TNF 22479555 2616110 Positive_regulation TMEM211 TNF 23766697 3154907 Positive_regulation TMEM211 TNFSF11 22479615 2616626 Positive_regulation TMEM211 TNFSF11 24558484 2923873 Positive_regulation TMEM211 TNFSF11 25489576 1236544 Positive_regulation TMEM211 TPT1 24465583 2911157 Positive_regulation TMEM211 TRIM3 19582228 1088710 Positive_regulation TMEM211 VEGFA 20616955 2120620 Positive_regulation TMEM211 XBP1 24705207 985339 Positive_regulation TMEM212 TNF 22479555 2616115 Positive_regulation TMEM212 TNF 23766697 3154912 Positive_regulation TMEM213 APP 24404197 2906462 Positive_regulation TMEM213 ATF6 23629671 1106260 Positive_regulation TMEM213 BCL10 24790593 681292 Positive_regulation TMEM213 BCL2 24790593 681293 Positive_regulation TMEM213 BCL3 24790593 681294 Positive_regulation TMEM213 BCL5 24790593 681289 Positive_regulation TMEM213 BCL6 24790593 681290 Positive_regulation TMEM213 BCL9 24790593 681291 Positive_regulation TMEM213 BDKRB2 24277599 1610839 Positive_regulation TMEM213 CSF1 22479615 2616501 Positive_regulation TMEM213 ERBB2 21443808 397782 Positive_regulation TMEM213 ERBB2 25137062 2999748 Positive_regulation TMEM213 F2RL1 24277599 1610840 Positive_regulation TMEM213 GH1 22500953 355523 Positive_regulation TMEM213 MYLIP 24098708 2859209 Positive_regulation TMEM213 NFATC1 23509596 817633 Positive_regulation TMEM213 NOTCH1 22679484 2649754 Positive_regulation TMEM213 NOTCH1 24395635 1414240 Positive_regulation TMEM213 NOTCH2 22679484 2649755 Positive_regulation TMEM213 NOTCH2 24395635 1414241 Positive_regulation TMEM213 NOTCH3 22679484 2649756 Positive_regulation TMEM213 NOTCH3 24395635 1414242 Positive_regulation TMEM213 NOTCH4 22679484 2649757 Positive_regulation TMEM213 NOTCH4 24395635 1414243 Positive_regulation TMEM213 PLXNB1 25137062 2999749 Positive_regulation TMEM213 PTCH1 24393163 1871151 Positive_regulation TMEM213 TNF 22479555 2616047 Positive_regulation TMEM213 TNF 23766697 3154844 Positive_regulation TMEM213 TNFSF11 22479615 2616500 Positive_regulation TMEM213 TNFSF11 24558484 2923809 Positive_regulation TMEM213 TNFSF11 25489576 1236481 Positive_regulation TMEM213 TPT1 24465583 2911094 Positive_regulation TMEM213 TRIM3 19582228 1088647 Positive_regulation TMEM213 VEGFA 20616955 2120557 Positive_regulation TMEM213 XBP1 24705207 985275 Positive_regulation TMEM214 TNF 22479555 2616020 Positive_regulation TMEM214 TNF 23766697 3154817 Positive_regulation TMEM215 TNF 22479555 2616113 Positive_regulation TMEM215 TNF 23766697 3154910 Positive_regulation TMEM216 TNF 22479555 2615991 Positive_regulation TMEM216 TNF 23766697 3154788 Positive_regulation TMEM217 TNF 22479555 2615976 Positive_regulation TMEM217 TNF 23766697 3154773 Positive_regulation TMEM218 TNF 22479555 2616049 Positive_regulation TMEM218 TNF 23766697 3154846 Positive_regulation TMEM219 TNF 22479555 2615997 Positive_regulation TMEM219 TNF 23766697 3154794 Positive_regulation TMEM220 TNF 22479555 2616112 Positive_regulation TMEM220 TNF 23766697 3154909 Positive_regulation TMEM221 TNF 22479555 2615982 Positive_regulation TMEM221 TNF 23766697 3154779 Positive_regulation TMEM222 TNF 22479555 2616001 Positive_regulation TMEM222 TNF 23766697 3154798 Positive_regulation TMEM223 TNF 22479555 2616072 Positive_regulation TMEM223 TNF 23766697 3154869 Positive_regulation TMEM225 TNF 22479555 2616103 Positive_regulation TMEM225 TNF 23766697 3154900 Positive_regulation TMEM230 TNF 22479555 2615962 Positive_regulation TMEM230 TNF 23766697 3154759 Positive_regulation TMEM231 TNF 22479555 2616117 Positive_regulation TMEM231 TNF 23766697 3154914 Positive_regulation TMEM232 TNF 22479555 2616118 Positive_regulation TMEM232 TNF 23766697 3154915 Positive_regulation TMEM233 TNF 22479555 2616116 Positive_regulation TMEM233 TNF 23766697 3154913 Positive_regulation TMEM234 TNF 22479555 2616082 Positive_regulation TMEM234 TNF 23766697 3154879 Positive_regulation TMEM235 TNF 22479555 2616051 Positive_regulation TMEM235 TNF 23766697 3154848 Positive_regulation TMEM236 TNF 22479555 2615985 Positive_regulation TMEM236 TNF 23766697 3154782 Positive_regulation TMEM237 TNF 22479555 2615961 Positive_regulation TMEM237 TNF 23766697 3154758 Positive_regulation TMEM238 TNF 22479555 2616119 Positive_regulation TMEM238 TNF 23766697 3154916 Positive_regulation TMEM239 TNF 22479555 2616120 Positive_regulation TMEM239 TNF 23766697 3154917 Positive_regulation TMEM240 TNF 22479555 2615996 Positive_regulation TMEM240 TNF 23766697 3154793 Positive_regulation TMEM241 TNF 22479555 2616096 Positive_regulation TMEM241 TNF 23766697 3154893 Positive_regulation TMEM242 TNF 22479555 2615966 Positive_regulation TMEM242 TNF 23766697 3154763 Positive_regulation TMEM243 TNF 22479555 2615978 Positive_regulation TMEM243 TNF 23766697 3154775 Positive_regulation TMEM244 TNF 22479555 2615977 Positive_regulation TMEM244 TNF 23766697 3154774 Positive_regulation TMEM245 TNF 22479555 2615958 Positive_regulation TMEM245 TNF 23766697 3154755 Positive_regulation TMEM246 TNF 22479555 2616060 Positive_regulation TMEM246 TNF 23766697 3154857 Positive_regulation TMEM247 TNF 22479555 2616121 Positive_regulation TMEM247 TNF 23766697 3154918 Positive_regulation TMEM248 TNF 22479555 2616005 Positive_regulation TMEM248 TNF 23766697 3154802 Positive_regulation TMEM249 TNF 22479555 2616122 Positive_regulation TMEM249 TNF 23766697 3154919 Positive_regulation TMEM25 TNF 22479555 2616019 Positive_regulation TMEM25 TNF 23766697 3154816 Positive_regulation TMEM251 TNF 22479555 2615973 Positive_regulation TMEM251 TNF 23766697 3154770 Positive_regulation TMEM252 TNF 22479555 2616074 Positive_regulation TMEM252 TNF 23766697 3154871 Positive_regulation TMEM253 TNF 22479555 2616105 Positive_regulation TMEM253 TNF 23766697 3154902 Positive_regulation TMEM254 TNF 22479555 2616016 Positive_regulation TMEM254 TNF 23766697 3154813 Positive_regulation TMEM256 TNF 22479555 2616077 Positive_regulation TMEM256 TNF 23766697 3154874 Positive_regulation TMEM257 TNF 22479555 2616013 Positive_regulation TMEM257 TNF 23766697 3154810 Positive_regulation TMEM258 TNF 22479555 2615954 Positive_regulation TMEM258 TNF 23766697 3154751 Positive_regulation TMEM259 TNF 22479555 2615965 Positive_regulation TMEM259 TNF 23766697 3154762 Positive_regulation TMEM26 TNF 22479555 2616075 Positive_regulation TMEM26 TNF 23766697 3154872 Positive_regulation TMEM260 TNF 22479555 2615972 Positive_regulation TMEM260 TNF 23766697 3154769 Positive_regulation TMEM261 TNF 22479555 2616093 Positive_regulation TMEM261 TNF 23766697 3154890 Positive_regulation TMEM27 TNF 22479555 2616083 Positive_regulation TMEM27 TNF 23766697 3154880 Positive_regulation TMEM31 TNF 22479555 2616076 Positive_regulation TMEM31 TNF 23766697 3154873 Positive_regulation TMEM33 TNF 22479555 2616007 Positive_regulation TMEM33 TNF 23766697 3154804 Positive_regulation TMEM35 TNF 22479555 2616018 Positive_regulation TMEM35 TNF 23766697 3154815 Positive_regulation TMEM37 ITGA9 24086773 2855774 Positive_regulation TMEM37 TNF 22479555 2615968 Positive_regulation TMEM37 TNF 23766697 3154765 Positive_regulation TMEM40 TNF 22479555 2616014 Positive_regulation TMEM40 TNF 23766697 3154811 Positive_regulation TMEM42 TNF 22479555 2616070 Positive_regulation TMEM42 TNF 23766697 3154867 Positive_regulation TMEM43 TNF 22479555 2616073 Positive_regulation TMEM43 TNF 23766697 3154870 Positive_regulation TMEM44 TNF 22479555 2615993 Positive_regulation TMEM44 TNF 23766697 3154790 Positive_regulation TMEM47 TNF 22479555 2615969 Positive_regulation TMEM47 TNF 23766697 3154766 Positive_regulation TMEM5 TNF 22479555 2615957 Positive_regulation TMEM5 TNF 23766697 3154754 Positive_regulation TMEM51 TNF 22479555 2616006 Positive_regulation TMEM51 TNF 23766697 3154803 Positive_regulation TMEM52 TNF 22479555 2616054 Positive_regulation TMEM52 TNF 23766697 3154851 Positive_regulation TMEM53 TNF 22479555 2616027 Positive_regulation TMEM53 TNF 23766697 3154824 Positive_regulation TMEM54 TNF 22479555 2615987 Positive_regulation TMEM54 TNF 23766697 3154784 Positive_regulation TMEM56 TNF 22479555 2616035 Positive_regulation TMEM56 TNF 23766697 3154832 Positive_regulation TMEM57 TNF 22479555 2616008 Positive_regulation TMEM57 TNF 23766697 3154805 Positive_regulation TMEM59 TNF 22479555 2615956 Positive_regulation TMEM59 TNF 23766697 3154753 Positive_regulation TMEM60 TNF 22479555 2615979 Positive_regulation TMEM60 TNF 23766697 3154776 Positive_regulation TMEM61 TNF 22479555 2616048 Positive_regulation TMEM61 TNF 23766697 3154845 Positive_regulation TMEM62 TNF 22479555 2616031 Positive_regulation TMEM62 TNF 23766697 3154828 Positive_regulation TMEM64 TNF 22479555 2616004 Positive_regulation TMEM64 TNF 23766697 3154801 Positive_regulation TMEM65 TNF 22479555 2615998 Positive_regulation TMEM65 TNF 23766697 3154795 Positive_regulation TMEM66 TNF 22479555 2616081 Positive_regulation TMEM66 TNF 23766697 3154878 Positive_regulation TMEM67 TNF 22479555 2616069 Positive_regulation TMEM67 TNF 23766697 3154866 Positive_regulation TMEM68 TNF 22479555 2616037 Positive_regulation TMEM68 TNF 23766697 3154834 Positive_regulation TMEM69 TNF 22479555 2616056 Positive_regulation TMEM69 TNF 23766697 3154853 Positive_regulation TMEM70 TNF 22479555 2616024 Positive_regulation TMEM70 TNF 23766697 3154821 Positive_regulation TMEM71 TNF 22479555 2616038 Positive_regulation TMEM71 TNF 23766697 3154835 Positive_regulation TMEM72 TNF 22479555 2616095 Positive_regulation TMEM72 TNF 23766697 3154892 Positive_regulation TMEM74 TNF 22479555 2616033 Positive_regulation TMEM74 TNF 23766697 3154830 Positive_regulation TMEM75 TNF 22479555 2616097 Positive_regulation TMEM75 TNF 23766697 3154894 Positive_regulation TMEM78 TNF 22479555 2616098 Positive_regulation TMEM78 TNF 23766697 3154895 Positive_regulation TMEM79 TNF 22479555 2616062 Positive_regulation TMEM79 TNF 23766697 3154859 Positive_regulation TMEM80 TNF 22479555 2616050 Positive_regulation TMEM80 TNF 23766697 3154847 Positive_regulation TMEM81 TNF 22479555 2616099 Positive_regulation TMEM81 TNF 23766697 3154896 Positive_regulation TMEM82 TNF 22479555 2616100 Positive_regulation TMEM82 TNF 23766697 3154897 Positive_regulation TMEM88 TNF 22479555 2616101 Positive_regulation TMEM88 TNF 23766697 3154898 Positive_regulation TMEM89 TNF 22479555 2616102 Positive_regulation TMEM89 TNF 23766697 3154899 Positive_regulation TMEM9 TNF 22479555 2615970 Positive_regulation TMEM9 TNF 23766697 3154767 Positive_regulation TMEM91 TNF 22479555 2616104 Positive_regulation TMEM91 TNF 23766697 3154901 Positive_regulation TMEM92 TNF 22479555 2616039 Positive_regulation TMEM92 TNF 23766697 3154836 Positive_regulation TMEM95 TNF 22479555 2616053 Positive_regulation TMEM95 TNF 23766697 3154850 Positive_regulation TMEM97 TNF 22479555 2616057 Positive_regulation TMEM97 TNF 23766697 3154854 Positive_regulation TMEM98 TNF 22479555 2615988 Positive_regulation TMEM98 TNF 23766697 3154785 Positive_regulation TMEM99 TNF 22479555 2616068 Positive_regulation TMEM99 TNF 23766697 3154865 Positive_regulation TMF1 FOXO1 23733015 2171411 Positive_regulation TMF1 ITGB2 7542512 702516 Positive_regulation TMF1 TNF 7542512 702510 Positive_regulation TMOD1 CA2 17630823 2289438 Positive_regulation TMOD1 CA2 17704185 211793 Positive_regulation TMOD1 CA2 17704185 211796 Positive_regulation TMOD1 CA2 18955596 1609268 Positive_regulation TMOD1 CA2 20161772 2440643 Positive_regulation TMOD1 CA2 20584889 1609740 Positive_regulation TMOD1 CA2 22493584 956940 Positive_regulation TMOD1 CA2 22493584 956944 Positive_regulation TMOD1 CA2 22589710 2296724 Positive_regulation TMOD1 CA2 23008774 155689 Positive_regulation TMOD1 CA2 23227172 2725602 Positive_regulation TMOD1 CA2 23401574 1610462 Positive_regulation TMOD1 CA2 23437068 2755498 Positive_regulation TMOD1 CA2 23530050 1206714 Positive_regulation TMOD1 CA2 25392916 3025351 Positive_regulation TMOD1 CAPN2 25324783 966515 Positive_regulation TMOD1 DMD 1577872 1318494 Positive_regulation TMOD1 MYO10 19041430 158274 Positive_regulation TMOD1 MYO10 22230661 3084383 Positive_regulation TMOD1 MYO10 22349210 600626 Positive_regulation TMOD1 MYO10 22675303 957601 Positive_regulation TMOD1 MYO10 22675303 957613 Positive_regulation TMOD1 MYO10 23001010 604902 Positive_regulation TMOD1 MYO10 25429108 1211197 Positive_regulation TMOD1 MYO10 25429108 1211237 Positive_regulation TMOD1 MYO16 19041430 158273 Positive_regulation TMOD1 MYO16 22230661 3084382 Positive_regulation TMOD1 MYO16 22349210 600625 Positive_regulation TMOD1 MYO16 22675303 957600 Positive_regulation TMOD1 MYO16 22675303 957612 Positive_regulation TMOD1 MYO16 23001010 604901 Positive_regulation TMOD1 MYO16 25429108 1211196 Positive_regulation TMOD1 MYO16 25429108 1211236 Positive_regulation TMOD1 MYO19 19041430 158272 Positive_regulation TMOD1 MYO19 22230661 3084381 Positive_regulation TMOD1 MYO19 22349210 600624 Positive_regulation TMOD1 MYO19 22675303 957599 Positive_regulation TMOD1 MYO19 22675303 957611 Positive_regulation TMOD1 MYO19 23001010 604900 Positive_regulation TMOD1 MYO19 25429108 1211195 Positive_regulation TMOD1 MYO19 25429108 1211235 Positive_regulation TMOD1 MYO6 19041430 158275 Positive_regulation TMOD1 MYO6 22230661 3084384 Positive_regulation TMOD1 MYO6 22349210 600627 Positive_regulation TMOD1 MYO6 22675303 957602 Positive_regulation TMOD1 MYO6 22675303 957614 Positive_regulation TMOD1 MYO6 23001010 604903 Positive_regulation TMOD1 MYO6 25429108 1211198 Positive_regulation TMOD1 MYO6 25429108 1211238 Positive_regulation TMOD1 NEB 16157704 1323982 Positive_regulation TMOD1 NEB 16157704 1323983 Positive_regulation TMOD1 NEB 20498015 1376450 Positive_regulation TMOD1 NEB 22013379 1222796 Positive_regulation TMOD1 NEB 25352808 966582 Positive_regulation TMOD1 NEBL 22375125 956447 Positive_regulation TMOD1 TMOD1 12975349 1296998 Positive_regulation TMOD1 TMOD1 12975349 1297067 Positive_regulation TMOD1 TMOD1 21727195 1389792 Positive_regulation TMOD1 TMOD1 24430868 1820489 Positive_regulation TMOD1 TMOD1 24586196 2357069 Positive_regulation TMOD1 TNNT2 24043862 1610591 Positive_regulation TMOD1 TPM1 12975349 1296999 Positive_regulation TMOD1 TPM1 12975349 1297068 Positive_regulation TMOD1 TPM1 12975349 1297096 Positive_regulation TMOD1 TPM1 7730404 1439798 Positive_regulation TMOD1 TPM1 7730404 1439799 Positive_regulation TMOD1 TPM1 8163552 1445368 Positive_regulation TMOD1 TPM1 8408215 1448242 Positive_regulation TMOD1 TPM2 12975349 1297000 Positive_regulation TMOD1 TPM2 12975349 1297069 Positive_regulation TMOD1 TPM2 12975349 1297097 Positive_regulation TMOD1 TPM2 7730404 1439800 Positive_regulation TMOD1 TPM2 7730404 1439801 Positive_regulation TMOD1 TPM2 8163552 1445369 Positive_regulation TMOD1 TPM2 8408215 1448243 Positive_regulation TMOD1 TPM3 12975349 1297001 Positive_regulation TMOD1 TPM3 12975349 1297070 Positive_regulation TMOD1 TPM3 12975349 1297098 Positive_regulation TMOD1 TPM3 7730404 1439802 Positive_regulation TMOD1 TPM3 7730404 1439803 Positive_regulation TMOD1 TPM3 8163552 1445370 Positive_regulation TMOD1 TPM3 8408215 1448244 Positive_regulation TMOD1 TPM4 12975349 1297002 Positive_regulation TMOD1 TPM4 12975349 1297071 Positive_regulation TMOD1 TPM4 12975349 1297099 Positive_regulation TMOD1 TPM4 7730404 1439804 Positive_regulation TMOD1 TPM4 7730404 1439805 Positive_regulation TMOD1 TPM4 8163552 1445371 Positive_regulation TMOD1 TPM4 8408215 1448245 Positive_regulation TMPRSS4 KAT5 23821596 992834 Positive_regulation TMPRSS4 MORF4L1 23821596 992826 Positive_regulation TMPRSS4 NCAPD3 24934155 1419772 Positive_regulation TMPRSS4 NCAPG2 24934155 1419770 Positive_regulation TMPRSS4 NCAPH2 24934155 1419771 Positive_regulation TMPRSS4 PLAU 24748857 1021880 Positive_regulation TMPRSS4 RPS27 24934155 1419767 Positive_regulation TMPRSS4 RPS27 24934155 1419820 Positive_regulation TMPRSS4 SMC2 24934155 1419768 Positive_regulation TMPRSS4 SMC4 24934155 1419769 Positive_regulation TMPRSS6 ID1 24376517 2901017 Positive_regulation TNC EPHB2 21818551 600147 Positive_regulation TNC MMP28 21818551 600228 Positive_regulation TNC MMP28 24324615 2890770 Positive_regulation TNC MMP7 21818551 600243 Positive_regulation TNC MMP7 24324615 2890785 Positive_regulation TNC TNF 18057520 736042 Positive_regulation TNC TNF 21205293 3111849 Positive_regulation TNC TNF 21205293 3111863 Positive_regulation TNC TNF 21205293 3111880 Positive_regulation TNC TNF 21205293 3111881 Positive_regulation TNC TNF 21818551 600222 Positive_regulation TNC TNF 23193984 127504 Positive_regulation TNC TNF 23958855 2157425 Positive_regulation TNF AATF 22933572 1807240 Positive_regulation TNF AATF 22933572 1807250 Positive_regulation TNF ABCB1 23642074 1666671 Positive_regulation TNF ABCC1 24086787 2372189 Positive_regulation TNF ABCC6 21350659 217494 Positive_regulation TNF ABCD1 21331379 979870 Positive_regulation TNF ABCD1 23755248 2802256 Positive_regulation TNF ACACA 24844551 512794 Positive_regulation TNF ACAN 22594821 125878 Positive_regulation TNF ACE 22626797 3129503 Positive_regulation TNF ACE 22649335 514885 Positive_regulation TNF ACE 23710335 513204 Positive_regulation TNF ACKR3 25084358 2994446 Positive_regulation TNF ACKR3 25084358 2994454 Positive_regulation TNF ACKR3 25084358 2994458 Positive_regulation TNF ACKR3 25084358 2994461 Positive_regulation TNF ACSM3 11748361 1632819 Positive_regulation TNF ACSM3 20731855 659653 Positive_regulation TNF ACSM3 20731855 659658 Positive_regulation TNF ACSM3 20731855 659665 Positive_regulation TNF ACSM3 21403869 1748825 Positive_regulation TNF ACSM3 21871121 1659643 Positive_regulation TNF ACSM3 23904869 1641460 Positive_regulation TNF ADA 22864384 1727509 Positive_regulation TNF ADAM10 22792380 2663534 Positive_regulation TNF ADAM10 24520307 2167693 Positive_regulation TNF ADAM10 24520307 2167694 Positive_regulation TNF ADAM11 22505996 2618050 Positive_regulation TNF ADAM17 11706054 1276107 Positive_regulation TNF ADAM17 12110119 98930 Positive_regulation TNF ADAM17 20463877 2291343 Positive_regulation TNF ADAM17 21375761 1697090 Positive_regulation TNF ADAM17 22319556 2595418 Positive_regulation TNF ADAM17 22319556 2595419 Positive_regulation TNF ADAM17 22319556 2595424 Positive_regulation TNF ADAM17 22319556 2595430 Positive_regulation TNF ADAM17 22319556 2595432 Positive_regulation TNF ADAM17 22389670 2607906 Positive_regulation TNF ADAM17 22389670 2607908 Positive_regulation TNF ADAM17 22792380 2663533 Positive_regulation TNF ADAM17 23251384 2728484 Positive_regulation TNF ADAM17 23251384 2728485 Positive_regulation TNF ADAM17 23341882 2741323 Positive_regulation TNF ADAM17 23389627 1811751 Positive_regulation TNF ADAM17 23437303 2756406 Positive_regulation TNF ADAM17 24672479 858871 Positive_regulation TNF ADAM17 24924541 3124777 Positive_regulation TNF ADAM17 25045210 1760148 Positive_regulation TNF ADAM17 25045936 2118870 Positive_regulation TNF ADAM17 25384035 3024618 Positive_regulation TNF ADAM17 25384035 3024627 Positive_regulation TNF ADAM17 PMC2798987 1146767 Positive_regulation TNF ADAM19 22792380 2663535 Positive_regulation TNF ADAMTS4 17177994 107710 Positive_regulation TNF ADAMTS5 17177994 107711 Positive_regulation TNF ADAMTS7 24876675 1758963 Positive_regulation TNF ADC 1740664 1545110 Positive_regulation TNF ADIPOQ 15689240 2112205 Positive_regulation TNF ADIPOQ 20156719 809178 Positive_regulation TNF ADIPOQ 20208553 9619 Positive_regulation TNF ADIPOQ 20825686 400964 Positive_regulation TNF ADIPOQ 21143922 3111752 Positive_regulation TNF ADIPOQ 22007173 950485 Positive_regulation TNF ADIPOQ 23302722 1709098 Positive_regulation TNF ADIPOQ 23381555 1140578 Positive_regulation TNF ADIPOQ 24936137 1085249 Positive_regulation TNF ADIPOQ 25538852 3086838 Positive_regulation TNF ADK 12106498 98926 Positive_regulation TNF AGA 21317295 717811 Positive_regulation TNF AGA 21317295 717812 Positive_regulation TNF AGA 21317295 717813 Positive_regulation TNF AGA 21317295 717814 Positive_regulation TNF AGA 21317295 717815 Positive_regulation TNF AGA 21317295 717820 Positive_regulation TNF AGA 21317295 717821 Positive_regulation TNF AGA 21317295 717822 Positive_regulation TNF AGA 21317295 717855 Positive_regulation TNF AGA 21317295 717856 Positive_regulation TNF AGA 21317295 717896 Positive_regulation TNF AGA 21317295 717916 Positive_regulation TNF AGA 21317295 717922 Positive_regulation TNF AGA 21317295 717923 Positive_regulation TNF AGA 21317295 717924 Positive_regulation TNF AGA 21317295 717926 Positive_regulation TNF AGA 21317295 717927 Positive_regulation TNF AGA 21317295 717931 Positive_regulation TNF AGA 21317295 717939 Positive_regulation TNF AGA 21317295 717940 Positive_regulation TNF AGA 21317295 717941 Positive_regulation TNF AGA 21317295 717943 Positive_regulation TNF AGT 18416854 2111296 Positive_regulation TNF AGTR1 23889808 1627690 Positive_regulation TNF AGTR1 24175973 275966 Positive_regulation TNF AGTR1 24626803 1035586 Positive_regulation TNF AGTR2 18481112 2235195 Positive_regulation TNF AGTR2 18778475 2232722 Positive_regulation TNF AGXT 23251471 2728662 Positive_regulation TNF AHI1 22248740 2177281 Positive_regulation TNF AHR 12204817 791183 Positive_regulation TNF AHR 22110376 1058214 Positive_regulation TNF AHR 22500183 1156044 Positive_regulation TNF AHR 23099484 795106 Positive_regulation TNF AHR 23099484 795112 Positive_regulation TNF AHR 24527450 186984 Positive_regulation TNF AHSA1 20070884 1852890 Positive_regulation TNF AHSA1 20070884 1852901 Positive_regulation TNF AHSA1 20087353 434404 Positive_regulation TNF AHSA1 20644716 2455937 Positive_regulation TNF AHSA1 21202091 2898 Positive_regulation TNF AHSA1 21314908 3209833 Positive_regulation TNF AHSA1 21961050 2224086 Positive_regulation TNF AHSA1 21984950 2561242 Positive_regulation TNF AHSA1 22829768 3058178 Positive_regulation TNF AHSA1 22909087 1626656 Positive_regulation TNF AHSA1 23227067 3204523 Positive_regulation TNF AHSA1 23331383 1675461 Positive_regulation TNF AHSA1 23549267 1104799 Positive_regulation TNF AHSA1 23549267 1104953 Positive_regulation TNF AHSA1 23672639 1666731 Positive_regulation TNF AHSA1 24205379 2876326 Positive_regulation TNF AHSA1 24304472 1482133 Positive_regulation TNF AHSA1 24404333 206101 Positive_regulation TNF AHSA1 24707477 188416 Positive_regulation TNF AHSA1 24722253 2951095 Positive_regulation TNF AHSA1 25530682 1763400 Positive_regulation TNF AHSG 18335040 2386914 Positive_regulation TNF AHSG 18335040 2386929 Positive_regulation TNF AHSG 18335040 2386940 Positive_regulation TNF AIF1 21317295 717899 Positive_regulation TNF AIM2 20351692 1953774 Positive_regulation TNF AKT1 10974038 1517027 Positive_regulation TNF AKT1 11238593 1519024 Positive_regulation TNF AKT1 19118493 651002 Positive_regulation TNF AKT1 21437087 731224 Positive_regulation TNF AKT1 21483870 2512548 Positive_regulation TNF AKT1 21949832 2556745 Positive_regulation TNF AKT1 21949832 2556776 Positive_regulation TNF AKT1 22426696 14556 Positive_regulation TNF AKT1 22606294 2642905 Positive_regulation TNF AKT1 22606294 2642906 Positive_regulation TNF AKT1 22606294 2642907 Positive_regulation TNF AKT1 22606294 2643008 Positive_regulation TNF AKT1 23071583 2703080 Positive_regulation TNF AKT1 23378844 905935 Positive_regulation TNF AKT1 23437404 2756825 Positive_regulation TNF AKT1 23755018 961351 Positive_regulation TNF AKT1 24008733 565903 Positive_regulation TNF AKT1 24206648 367414 Positive_regulation TNF AKT1 24206648 367424 Positive_regulation TNF AKT1 24577082 572421 Positive_regulation TNF AKT1 24577082 572427 Positive_regulation TNF AKT1 25132732 1760491 Positive_regulation TNF AKT1 25540945 1654252 Positive_regulation TNF AKT2 10974038 1517028 Positive_regulation TNF AKT2 11238593 1519025 Positive_regulation TNF AKT2 19118493 651003 Positive_regulation TNF AKT2 21483870 2512549 Positive_regulation TNF AKT2 21949832 2556746 Positive_regulation TNF AKT2 21949832 2556777 Positive_regulation TNF AKT2 22426696 14557 Positive_regulation TNF AKT2 22606294 2642908 Positive_regulation TNF AKT2 22606294 2642909 Positive_regulation TNF AKT2 22606294 2642910 Positive_regulation TNF AKT2 22606294 2643009 Positive_regulation TNF AKT2 23071583 2703081 Positive_regulation TNF AKT2 23378844 905936 Positive_regulation TNF AKT2 23437404 2756826 Positive_regulation TNF AKT2 23755018 961352 Positive_regulation TNF AKT2 23805905 1726148 Positive_regulation TNF AKT2 24008733 565904 Positive_regulation TNF AKT2 24577082 572422 Positive_regulation TNF AKT2 24577082 572428 Positive_regulation TNF AKT2 25132732 1760492 Positive_regulation TNF AKT2 25540945 1654253 Positive_regulation TNF AKT3 10974038 1517029 Positive_regulation TNF AKT3 11238593 1519026 Positive_regulation TNF AKT3 19118493 651004 Positive_regulation TNF AKT3 21483870 2512550 Positive_regulation TNF AKT3 21949832 2556747 Positive_regulation TNF AKT3 21949832 2556778 Positive_regulation TNF AKT3 22426696 14558 Positive_regulation TNF AKT3 22606294 2642911 Positive_regulation TNF AKT3 22606294 2642912 Positive_regulation TNF AKT3 22606294 2642913 Positive_regulation TNF AKT3 22606294 2643010 Positive_regulation TNF AKT3 23071583 2703082 Positive_regulation TNF AKT3 23378844 905937 Positive_regulation TNF AKT3 23437404 2756827 Positive_regulation TNF AKT3 23755018 961353 Positive_regulation TNF AKT3 24008733 565905 Positive_regulation TNF AKT3 24577082 572423 Positive_regulation TNF AKT3 24577082 572429 Positive_regulation TNF AKT3 25132732 1760493 Positive_regulation TNF AKT3 25540945 1654254 Positive_regulation TNF ALB 15826301 224723 Positive_regulation TNF ALB 15826301 224724 Positive_regulation TNF ALB 15826301 224725 Positive_regulation TNF ALB 17183656 2373748 Positive_regulation TNF ALB 21042558 1912081 Positive_regulation TNF ALB 21042558 1912090 Positive_regulation TNF ALB 21042558 1912095 Positive_regulation TNF ALB 21042558 1912097 Positive_regulation TNF ALB 21042558 1912099 Positive_regulation TNF ALB 21042558 1912101 Positive_regulation TNF ALB 21042558 1912102 Positive_regulation TNF ALB 21266043 286085 Positive_regulation TNF ALB 23382978 2747414 Positive_regulation TNF ALB 23936610 2226595 Positive_regulation TNF ALB 25258680 1675220 Positive_regulation TNF ALOX5 19065997 3208646 Positive_regulation TNF ALPI 23533546 656744 Positive_regulation TNF ANGPT1 15642148 102421 Positive_regulation TNF ANGPT2 21131996 12192 Positive_regulation TNF ANGPT2 21234405 506702 Positive_regulation TNF ANGPT2 23251471 2728668 Positive_regulation TNF ANGPT2 23691105 2794518 Positive_regulation TNF ANGPT2 24818164 1496424 Positive_regulation TNF ANGPT2 25110549 2229814 Positive_regulation TNF ANK1 21912565 633180 Positive_regulation TNF ANKRD1 22808421 3130951 Positive_regulation TNF ANXA1 21736731 1898357 Positive_regulation TNF ANXA1 22011168 354796 Positive_regulation TNF ANXA2 24591759 738315 Positive_regulation TNF ANXA6 11879539 98555 Positive_regulation TNF ANXA6 21591259 776231 Positive_regulation TNF ANXA6 21829352 3052595 Positive_regulation TNF ANXA6 24568275 357521 Positive_regulation TNF ANXA6 24586980 2928543 Positive_regulation TNF AOM 24212934 499127 Positive_regulation TNF AOM 24766737 1701703 Positive_regulation TNF AOM 25337584 1241768 Positive_regulation TNF APC 11790888 735811 Positive_regulation TNF APC 15458574 350574 Positive_regulation TNF APC 19229322 3043327 Positive_regulation TNF APC 22879717 88202 Positive_regulation TNF APC 23295066 1733898 Positive_regulation TNF APCS 24101382 1573845 Positive_regulation TNF APCS 9362537 1602051 Positive_regulation TNF APEH 22195697 1626461 Positive_regulation TNF APEH 24829522 1758607 Positive_regulation TNF APOB 12366867 350312 Positive_regulation TNF APOB 16322770 3039070 Positive_regulation TNF APOB 20846396 353594 Positive_regulation TNF APOB 22359537 2597553 Positive_regulation TNF APOB 22567283 1139555 Positive_regulation TNF APOB 22567283 1139557 Positive_regulation TNF APOB 22956783 1637609 Positive_regulation TNF APOB 23024745 2689660 Positive_regulation TNF APOB 23139770 2713899 Positive_regulation TNF APOB 23825600 2809791 Positive_regulation TNF APOB 24386260 2903395 Positive_regulation TNF APOB 24666525 511381 Positive_regulation TNF APOB 24666525 511382 Positive_regulation TNF APOB 24991087 1759994 Positive_regulation TNF APOB 25388834 1485879 Positive_regulation TNF ARAF 7790814 1592134 Positive_regulation TNF ARCN1 23384071 3113506 Positive_regulation TNF AREG 20161853 1043919 Positive_regulation TNF AREG 23905066 3188199 Positive_regulation TNF ARG1 19696185 710960 Positive_regulation TNF ARG1 20811626 2473311 Positive_regulation TNF ARG1 22069588 3182547 Positive_regulation TNF ARG1 22272040 1694258 Positive_regulation TNF ARG1 23577028 1674550 Positive_regulation TNF ARG1 25501750 3033680 Positive_regulation TNF ARG1 3260938 1580632 Positive_regulation TNF ARG1 3260938 1580652 Positive_regulation TNF ARG2 19696185 710961 Positive_regulation TNF ARG2 20811626 2473312 Positive_regulation TNF ARG2 22069588 3182548 Positive_regulation TNF ARG2 25501750 3033681 Positive_regulation TNF ARG2 3260938 1580633 Positive_regulation TNF ARG2 3260938 1580653 Positive_regulation TNF ARHGEF7 2170559 1564094 Positive_regulation TNF ARID4B 7931061 1593039 Positive_regulation TNF ARSA 22695475 265032 Positive_regulation TNF ARSA 25061812 2992428 Positive_regulation TNF ARSH 12676602 791625 Positive_regulation TNF ASAH2 16818673 1541045 Positive_regulation TNF ATAD2 16882346 3116230 Positive_regulation TNF ATF2 12361922 791231 Positive_regulation TNF ATF2 12361922 791235 Positive_regulation TNF ATF2 23789107 169957 Positive_regulation TNF ATF3 22053207 2568025 Positive_regulation TNF ATF3 22614010 2147050 Positive_regulation TNF ATF3 24062788 822840 Positive_regulation TNF ATF4 25530974 1496784 Positive_regulation TNF ATG10 22479483 2615528 Positive_regulation TNF ATG10 22479483 2615542 Positive_regulation TNF ATG12 22479483 2615531 Positive_regulation TNF ATG12 22479483 2615545 Positive_regulation TNF ATG13 22479483 2615530 Positive_regulation TNF ATG13 22479483 2615544 Positive_regulation TNF ATG14 22479483 2615527 Positive_regulation TNF ATG14 22479483 2615541 Positive_regulation TNF ATG16L1 25580435 202401 Positive_regulation TNF ATG3 22479483 2615529 Positive_regulation TNF ATG3 22479483 2615543 Positive_regulation TNF ATG5 22479483 2615532 Positive_regulation TNF ATG5 22479483 2615546 Positive_regulation TNF ATG5 24710474 618098 Positive_regulation TNF ATG7 22479483 2615526 Positive_regulation TNF ATG7 22479483 2615540 Positive_regulation TNF ATP2A2 25421889 3224478 Positive_regulation TNF ATP8A2 10732775 416663 Positive_regulation TNF ATP8A2 22915524 1225744 Positive_regulation TNF ATP8A2 24941071 2980780 Positive_regulation TNF ATP8A2 9184176 446249 Positive_regulation TNF AXL 23071254 1569609 Positive_regulation TNF AZU1 21794177 3084319 Positive_regulation TNF B2M 24839609 1621572 Positive_regulation TNF B3GALT4 16100442 1634639 Positive_regulation TNF BAG6 18852879 2397428 Positive_regulation TNF BAI1 24551846 187122 Positive_regulation TNF BAI2 24551846 187123 Positive_regulation TNF BAI3 24551846 187124 Positive_regulation TNF BANF1 19814828 3212918 Positive_regulation TNF BANF1 22883744 1664696 Positive_regulation TNF BANF1 22883744 1664700 Positive_regulation TNF BANF1 22883744 1664716 Positive_regulation TNF BANF1 22883744 1664753 Positive_regulation TNF BCL10 16432253 1539470 Positive_regulation TNF BCL10 23437404 2756829 Positive_regulation TNF BCL10 23593410 2781180 Positive_regulation TNF BCL10 23922952 2827750 Positive_regulation TNF BCL2 23437404 2756830 Positive_regulation TNF BCL2 23573146 818489 Positive_regulation TNF BCL2 23593410 2781181 Positive_regulation TNF BCL3 23437404 2756831 Positive_regulation TNF BCL3 23593410 2781182 Positive_regulation TNF BCL3 24058765 1705136 Positive_regulation TNF BCL5 23437404 2756821 Positive_regulation TNF BCL5 23593410 2781176 Positive_regulation TNF BCL6 23437404 2756822 Positive_regulation TNF BCL6 23593410 2781177 Positive_regulation TNF BCL9 23437404 2756823 Positive_regulation TNF BCL9 23593410 2781178 Positive_regulation TNF BECN1 24710474 618097 Positive_regulation TNF BID 23996004 451647 Positive_regulation TNF BIRC2 19657383 2422802 Positive_regulation TNF BIRC2 23437404 2756904 Positive_regulation TNF BIRC3 16332260 248988 Positive_regulation TNF BIRC3 23437404 2756905 Positive_regulation TNF BLM 20137099 3110252 Positive_regulation TNF BLM 20137099 3110257 Positive_regulation TNF BLM 20137099 3110258 Positive_regulation TNF BMP2 22363102 1749679 Positive_regulation TNF BMP2 24820069 453990 Positive_regulation TNF BMP2 24820069 453991 Positive_regulation TNF BMP2 25132736 1760574 Positive_regulation TNF BMP2 25132736 1760575 Positive_regulation TNF BMP2 25132736 1760582 Positive_regulation TNF BMP2 25248109 3009285 Positive_regulation TNF BMP4 25132736 1760576 Positive_regulation TNF BMP6 25426114 915245 Positive_regulation TNF BMP7 24190429 1573983 Positive_regulation TNF BTK 20507741 787052 Positive_regulation TNF BTK 21611196 2523833 Positive_regulation TNF BTK 21611196 2523842 Positive_regulation TNF BTK 21611196 2523847 Positive_regulation TNF BTK 21611196 2523860 Positive_regulation TNF BTK 22592745 694253 Positive_regulation TNF BTK 9547335 1602610 Positive_regulation TNF BTRC 21559359 2518414 Positive_regulation TNF C12orf57 11257135 1519089 Positive_regulation TNF C1orf228 21298114 2499880 Positive_regulation TNF C1orf228 25552899 744119 Positive_regulation TNF C1QA 24252536 5826 Positive_regulation TNF C1QB 24252536 5827 Positive_regulation TNF C1S 22028815 2564411 Positive_regulation TNF C3 21736743 1658733 Positive_regulation TNF C3 21855168 1041326 Positive_regulation TNF C3 21855168 1041345 Positive_regulation TNF C3 22069473 2569037 Positive_regulation TNF C3 22069473 2569045 Positive_regulation TNF C4A 24789665 1886432 Positive_regulation TNF C5 17235375 1238287 Positive_regulation TNF C5 18426986 1550558 Positive_regulation TNF C5 18426986 1550563 Positive_regulation TNF C5 20652897 774883 Positive_regulation TNF C5 2165128 1564031 Positive_regulation TNF C5 21736743 1658734 Positive_regulation TNF C5 21855168 1041327 Positive_regulation TNF C5 21855168 1041346 Positive_regulation TNF C5 22069473 2569046 Positive_regulation TNF C5 23233853 905368 Positive_regulation TNF C5 24789665 1886402 Positive_regulation TNF C5 24789665 1886426 Positive_regulation TNF C5 24814708 145429 Positive_regulation TNF C5 3260938 1580630 Positive_regulation TNF C5 3260938 1580631 Positive_regulation TNF C5 3260938 1580646 Positive_regulation TNF C5 3260938 1580651 Positive_regulation TNF C5 3260938 1580670 Positive_regulation TNF C5 3260938 1580672 Positive_regulation TNF C5 8294868 1594833 Positive_regulation TNF C5 9271590 1601594 Positive_regulation TNF C5 9271590 1601623 Positive_regulation TNF C5AR1 18426986 1550561 Positive_regulation TNF C5AR1 23233853 905143 Positive_regulation TNF C5AR1 24814708 145430 Positive_regulation TNF CA2 15935092 3105015 Positive_regulation TNF CA2 18404427 3087195 Positive_regulation TNF CA2 19065997 3208640 Positive_regulation TNF CA2 22701456 901660 Positive_regulation TNF CA2 23420671 906050 Positive_regulation TNF CA2 23564188 1879566 Positive_regulation TNF CA2 23922331 781535 Positive_regulation TNF CA2 24466329 2914349 Positive_regulation TNF CA2 24885636 273450 Positive_regulation TNF CA2 2536067 1577277 Positive_regulation TNF CA7 23193206 729913 Positive_regulation TNF CA8 22815752 2665962 Positive_regulation TNF CABP1 11667965 3102813 Positive_regulation TNF CABP2 11667965 3102814 Positive_regulation TNF CABP4 11667965 3102815 Positive_regulation TNF CABP5 11667965 3102812 Positive_regulation TNF CABP7 11667965 3102817 Positive_regulation TNF CADM1 18472842 1742228 Positive_regulation TNF CADM1 25061328 645474 Positive_regulation TNF CADM2 18472842 1742226 Positive_regulation TNF CADM2 25061328 645467 Positive_regulation TNF CADM3 18472842 1742225 Positive_regulation TNF CADM3 25061328 645466 Positive_regulation TNF CADM4 18472842 1742227 Positive_regulation TNF CADM4 25061328 645468 Positive_regulation TNF CALB1 11667965 3102816 Positive_regulation TNF CALD1 24901006 192566 Positive_regulation TNF CALM3 24968272 1127937 Positive_regulation TNF CALML3 19594900 659255 Positive_regulation TNF CALML3 21591259 776230 Positive_regulation TNF CALML3 22356547 660187 Positive_regulation TNF CALML3 22356547 660192 Positive_regulation TNF CALML3 22356547 660193 Positive_regulation TNF CALML3 25136402 655429 Positive_regulation TNF CALML3 25525303 1763346 Positive_regulation TNF CAMP 22125552 923838 Positive_regulation TNF CAMP 24901012 1621725 Positive_regulation TNF CARD9 21283787 3051078 Positive_regulation TNF CASP1 19440308 2416480 Positive_regulation TNF CASP1 22536153 3056413 Positive_regulation TNF CASP1 22661946 951848 Positive_regulation TNF CASP1 22737580 86562 Positive_regulation TNF CASP1 22737580 86576 Positive_regulation TNF CASP1 23010656 795065 Positive_regulation TNF CASP1 23086037 724988 Positive_regulation TNF CASP1 23637985 2786856 Positive_regulation TNF CASP1 23846218 563910 Positive_regulation TNF CASP1 23846218 563923 Positive_regulation TNF CASP1 24028654 622225 Positive_regulation TNF CASP1 24028654 622251 Positive_regulation TNF CASP1 24762050 132293 Positive_regulation TNF CASP1 24762050 132294 Positive_regulation TNF CASP1 24762050 132308 Positive_regulation TNF CASP1 24762050 132316 Positive_regulation TNF CASP1 9565639 1602716 Positive_regulation TNF CASP10 19440308 2416481 Positive_regulation TNF CASP10 22737580 86563 Positive_regulation TNF CASP10 22737580 86577 Positive_regulation TNF CASP10 23846218 563911 Positive_regulation TNF CASP10 23846218 563924 Positive_regulation TNF CASP10 24028654 622226 Positive_regulation TNF CASP10 24028654 622252 Positive_regulation TNF CASP10 9565639 1602717 Positive_regulation TNF CASP12 19440308 2416491 Positive_regulation TNF CASP12 22570745 1024137 Positive_regulation TNF CASP12 22737580 86573 Positive_regulation TNF CASP12 22737580 86587 Positive_regulation TNF CASP12 23846218 563921 Positive_regulation TNF CASP12 23846218 563934 Positive_regulation TNF CASP12 24028654 622236 Positive_regulation TNF CASP12 24028654 622262 Positive_regulation TNF CASP12 9565639 1602727 Positive_regulation TNF CASP14 19440308 2416482 Positive_regulation TNF CASP14 22737580 86564 Positive_regulation TNF CASP14 22737580 86578 Positive_regulation TNF CASP14 23846218 563912 Positive_regulation TNF CASP14 23846218 563925 Positive_regulation TNF CASP14 24028654 622227 Positive_regulation TNF CASP14 24028654 622253 Positive_regulation TNF CASP14 9565639 1602718 Positive_regulation TNF CASP16 19440308 2416492 Positive_regulation TNF CASP16 22737580 86574 Positive_regulation TNF CASP16 22737580 86588 Positive_regulation TNF CASP16 23846218 563922 Positive_regulation TNF CASP16 23846218 563935 Positive_regulation TNF CASP16 24028654 622237 Positive_regulation TNF CASP16 24028654 622263 Positive_regulation TNF CASP16 9565639 1602728 Positive_regulation TNF CASP2 19440308 2416483 Positive_regulation TNF CASP2 22737580 86565 Positive_regulation TNF CASP2 22737580 86579 Positive_regulation TNF CASP2 23846218 563913 Positive_regulation TNF CASP2 23846218 563926 Positive_regulation TNF CASP2 24028654 622228 Positive_regulation TNF CASP2 24028654 622254 Positive_regulation TNF CASP2 9565639 1602719 Positive_regulation TNF CASP3 11136825 1518325 Positive_regulation TNF CASP3 11696595 1521643 Positive_regulation TNF CASP3 16929248 427961 Positive_regulation TNF CASP3 19440308 2416484 Positive_regulation TNF CASP3 19818125 3091167 Positive_regulation TNF CASP3 21311098 2174895 Positive_regulation TNF CASP3 22471589 1230540 Positive_regulation TNF CASP3 22737580 86566 Positive_regulation TNF CASP3 22737580 86580 Positive_regulation TNF CASP3 23193206 729914 Positive_regulation TNF CASP3 23193206 729915 Positive_regulation TNF CASP3 23202309 3184262 Positive_regulation TNF CASP3 23846218 563914 Positive_regulation TNF CASP3 23846218 563927 Positive_regulation TNF CASP3 23882270 908316 Positive_regulation TNF CASP3 24028654 622229 Positive_regulation TNF CASP3 24028654 622255 Positive_regulation TNF CASP3 24484528 856860 Positive_regulation TNF CASP3 24739976 2118816 Positive_regulation TNF CASP3 25130514 1483832 Positive_regulation TNF CASP3 25290670 3012580 Positive_regulation TNF CASP3 9565639 1602720 Positive_regulation TNF CASP4 19440308 2416485 Positive_regulation TNF CASP4 22737580 86567 Positive_regulation TNF CASP4 22737580 86581 Positive_regulation TNF CASP4 23846218 563915 Positive_regulation TNF CASP4 23846218 563928 Positive_regulation TNF CASP4 24028654 622230 Positive_regulation TNF CASP4 24028654 622256 Positive_regulation TNF CASP4 9565639 1602721 Positive_regulation TNF CASP5 19440308 2416486 Positive_regulation TNF CASP5 22737580 86568 Positive_regulation TNF CASP5 22737580 86582 Positive_regulation TNF CASP5 23846218 563916 Positive_regulation TNF CASP5 23846218 563929 Positive_regulation TNF CASP5 24028654 622231 Positive_regulation TNF CASP5 24028654 622257 Positive_regulation TNF CASP5 9565639 1602722 Positive_regulation TNF CASP6 19440308 2416487 Positive_regulation TNF CASP6 22737580 86569 Positive_regulation TNF CASP6 22737580 86583 Positive_regulation TNF CASP6 23846218 563917 Positive_regulation TNF CASP6 23846218 563930 Positive_regulation TNF CASP6 24028654 622232 Positive_regulation TNF CASP6 24028654 622258 Positive_regulation TNF CASP6 9565639 1602723 Positive_regulation TNF CASP7 19440308 2416488 Positive_regulation TNF CASP7 22737580 86570 Positive_regulation TNF CASP7 22737580 86584 Positive_regulation TNF CASP7 22815752 2665963 Positive_regulation TNF CASP7 23846218 563918 Positive_regulation TNF CASP7 23846218 563931 Positive_regulation TNF CASP7 24028654 622233 Positive_regulation TNF CASP7 24028654 622259 Positive_regulation TNF CASP7 24484528 856861 Positive_regulation TNF CASP7 9565639 1602724 Positive_regulation TNF CASP8 19440308 2416489 Positive_regulation TNF CASP8 19818125 3091168 Positive_regulation TNF CASP8 20429941 328880 Positive_regulation TNF CASP8 21569377 1658339 Positive_regulation TNF CASP8 21654827 552288 Positive_regulation TNF CASP8 22253841 2588194 Positive_regulation TNF CASP8 22737580 86571 Positive_regulation TNF CASP8 22737580 86585 Positive_regulation TNF CASP8 23193206 729916 Positive_regulation TNF CASP8 23328672 559007 Positive_regulation TNF CASP8 23328672 559028 Positive_regulation TNF CASP8 23386613 1206401 Positive_regulation TNF CASP8 23846218 563919 Positive_regulation TNF CASP8 23846218 563932 Positive_regulation TNF CASP8 24028654 622234 Positive_regulation TNF CASP8 24028654 622260 Positive_regulation TNF CASP8 24421891 2909238 Positive_regulation TNF CASP8 24772178 825593 Positive_regulation TNF CASP8 24795644 964968 Positive_regulation TNF CASP8 25130514 1483833 Positive_regulation TNF CASP8 25394560 1887347 Positive_regulation TNF CASP8 9565639 1602725 Positive_regulation TNF CASP9 19440308 2416490 Positive_regulation TNF CASP9 21311098 2174896 Positive_regulation TNF CASP9 22737580 86572 Positive_regulation TNF CASP9 22737580 86586 Positive_regulation TNF CASP9 23193206 729917 Positive_regulation TNF CASP9 23846218 563920 Positive_regulation TNF CASP9 23846218 563933 Positive_regulation TNF CASP9 24028654 622235 Positive_regulation TNF CASP9 24028654 622261 Positive_regulation TNF CASP9 9565639 1602726 Positive_regulation TNF CAT 2109037 1561571 Positive_regulation TNF CBR1 19476641 1897222 Positive_regulation TNF CCAR1 25033461 2990319 Positive_regulation TNF CCDC88A 23967134 2834564 Positive_regulation TNF CCL11 24648846 1156520 Positive_regulation TNF CCL18 17875202 109078 Positive_regulation TNF CCL18 17875202 109082 Positive_regulation TNF CCL18 17875202 109090 Positive_regulation TNF CCL19 25473269 743502 Positive_regulation TNF CCL2 14641910 317002 Positive_regulation TNF CCL2 16987412 384040 Positive_regulation TNF CCL2 17764562 461017 Positive_regulation TNF CCL2 18410682 110364 Positive_regulation TNF CCL2 18410682 110370 Positive_regulation TNF CCL2 18410682 110453 Positive_regulation TNF CCL2 18558008 323723 Positive_regulation TNF CCL2 18633103 706476 Positive_regulation TNF CCL2 1911209 431527 Positive_regulation TNF CCL2 20072629 2437016 Positive_regulation TNF CCL2 20305745 2214362 Positive_regulation TNF CCL2 20480037 1090223 Positive_regulation TNF CCL2 21029292 590581 Positive_regulation TNF CCL2 22110387 1058543 Positive_regulation TNF CCL2 22414048 1626495 Positive_regulation TNF CCL2 22414048 1626496 Positive_regulation TNF CCL2 23091461 959479 Positive_regulation TNF CCL2 23455155 2110745 Positive_regulation TNF CCL2 23468966 2760304 Positive_regulation TNF CCL2 24088372 2233550 Positive_regulation TNF CCL2 24130892 2867519 Positive_regulation TNF CCL2 24130892 2867527 Positive_regulation TNF CCL2 24141950 1991006 Positive_regulation TNF CCL2 24405660 1667532 Positive_regulation TNF CCL2 24416415 2908743 Positive_regulation TNF CCL2 24426777 1916720 Positive_regulation TNF CCL2 24603712 2931969 Positive_regulation TNF CCL2 24826069 1916990 Positive_regulation TNF CCL2 24826069 1916991 Positive_regulation TNF CCL2 24826069 1916992 Positive_regulation TNF CCL2 24826069 1916993 Positive_regulation TNF CCL2 24826069 1916994 Positive_regulation TNF CCL2 24826069 1916995 Positive_regulation TNF CCL2 24826069 1916996 Positive_regulation TNF CCL2 24826069 1916997 Positive_regulation TNF CCL2 24826069 1917012 Positive_regulation TNF CCL2 24835211 2971005 Positive_regulation TNF CCL2 25117537 2996614 Positive_regulation TNF CCL20 23238132 651886 Positive_regulation TNF CCL20 23283206 3225507 Positive_regulation TNF CCL20 23283206 3225532 Positive_regulation TNF CCL20 23300534 2733675 Positive_regulation TNF CCL20 23732752 1632241 Positive_regulation TNF CCL20 24722370 2951373 Positive_regulation TNF CCL20 24722370 2951377 Positive_regulation TNF CCL20 24722370 2951382 Positive_regulation TNF CCL21 19804625 117454 Positive_regulation TNF CCL23 10974036 1516922 Positive_regulation TNF CCL23 10974036 1516926 Positive_regulation TNF CCL23 21858117 2546376 Positive_regulation TNF CCL23 23283206 3225508 Positive_regulation TNF CCL23 23283206 3225533 Positive_regulation TNF CCL23 23331383 1675457 Positive_regulation TNF CCL28 23300534 2733676 Positive_regulation TNF CCL3 17698589 1546792 Positive_regulation TNF CCL3 17698589 1546820 Positive_regulation TNF CCL3 20634957 2455653 Positive_regulation TNF CCL3 22241983 3055378 Positive_regulation TNF CCL3 24926881 2979839 Positive_regulation TNF CCL4 18560566 2391333 Positive_regulation TNF CCL4 22291795 95045 Positive_regulation TNF CCL4 23374533 2113852 Positive_regulation TNF CCL4 25171482 3004261 Positive_regulation TNF CCL5 19934004 711839 Positive_regulation TNF CCL5 20604932 119271 Positive_regulation TNF CCL5 22048272 737066 Positive_regulation TNF CCL5 24603712 2931970 Positive_regulation TNF CCNA2 25378811 1763114 Positive_regulation TNF CCNC 19712471 1625648 Positive_regulation TNF CCNC 24971461 2984394 Positive_regulation TNF CCNC 7540649 1590292 Positive_regulation TNF CCND1 21221075 1717671 Positive_regulation TNF CCNG1 11581316 1521082 Positive_regulation TNF CCNH 21062494 313322 Positive_regulation TNF CCR2 23758766 3121890 Positive_regulation TNF CCR2 24130892 2867543 Positive_regulation TNF CCR2 24130892 2867544 Positive_regulation TNF CCR7 12186834 1524515 Positive_regulation TNF CD14 12061425 1738148 Positive_regulation TNF CD14 17242961 810077 Positive_regulation TNF CD14 17242961 810087 Positive_regulation TNF CD14 17242961 810097 Positive_regulation TNF CD14 20419140 2447166 Positive_regulation TNF CD14 20946675 1723323 Positive_regulation TNF CD14 21352551 1626333 Positive_regulation TNF CD14 22194732 923857 Positive_regulation TNF CD14 22489138 1095384 Positive_regulation TNF CD14 22662179 2647143 Positive_regulation TNF CD14 23817990 1886207 Positive_regulation TNF CD14 24165011 3123876 Positive_regulation TNF CD14 24349012 2896620 Positive_regulation TNF CD14 24489448 1757424 Positive_regulation TNF CD14 24489448 1757435 Positive_regulation TNF CD14 24829682 1769052 Positive_regulation TNF CD14 25025695 2989282 Positive_regulation TNF CD160 20150970 1213775 Positive_regulation TNF CD160 21482699 1563313 Positive_regulation TNF CD160 23593209 2780312 Positive_regulation TNF CD160 24516120 1575039 Positive_regulation TNF CD163 23781295 2226303 Positive_regulation TNF CD19 20617141 1215578 Positive_regulation TNF CD19 20617141 1215580 Positive_regulation TNF CD2 25505551 1037376 Positive_regulation TNF CD207 12186835 1524543 Positive_regulation TNF CD209 15837813 1535589 Positive_regulation TNF CD27 15184507 1532878 Positive_regulation TNF CD274 17000870 1542517 Positive_regulation TNF CD274 22389764 3130465 Positive_regulation TNF CD274 24187568 639033 Positive_regulation TNF CD274 25125485 505185 Positive_regulation TNF CD276 21931843 2555041 Positive_regulation TNF CD28 11854362 1522988 Positive_regulation TNF CD28 18670628 3041676 Positive_regulation TNF CD28 22591674 1698344 Positive_regulation TNF CD28 22591674 1698346 Positive_regulation TNF CD28 23077634 2705064 Positive_regulation TNF CD28 24396625 1150506 Positive_regulation TNF CD28 8676068 1597816 Positive_regulation TNF CD28 8676089 1597979 Positive_regulation TNF CD28 9529314 1602560 Positive_regulation TNF CD33 22500980 355772 Positive_regulation TNF CD33 22500980 355786 Positive_regulation TNF CD33 24391502 3065871 Positive_regulation TNF CD36 22349260 600636 Positive_regulation TNF CD36 24743542 2955620 Positive_regulation TNF CD36 25075740 2993141 Positive_regulation TNF CD4 23977084 2838331 Positive_regulation TNF CD4 24795723 912562 Positive_regulation TNF CD4 24936469 3167015 Positive_regulation TNF CD4 PMC3920362 3102775 Positive_regulation TNF CD40 10839815 1515750 Positive_regulation TNF CD40 12566416 1525858 Positive_regulation TNF CD40 12823847 99839 Positive_regulation TNF CD40 16104828 2368418 Positive_regulation TNF CD40 16343349 1654820 Positive_regulation TNF CD40 16417648 459583 Positive_regulation TNF CD40 16469120 459660 Positive_regulation TNF CD40 17296788 1544376 Positive_regulation TNF CD40 18478117 2388658 Positive_regulation TNF CD40 19956549 2432032 Positive_regulation TNF CD40 20100871 1557332 Positive_regulation TNF CD40 20429874 1656230 Positive_regulation TNF CD40 22110533 633562 Positive_regulation TNF CD40 22110533 633569 Positive_regulation TNF CD40 23238132 651919 Positive_regulation TNF CD40 23533546 656753 Positive_regulation TNF CD40 23990781 3063832 Positive_regulation TNF CD40 23990781 3063839 Positive_regulation TNF CD40 25071777 913388 Positive_regulation TNF CD40 25375372 578821 Positive_regulation TNF CD40 8642284 1596630 Positive_regulation TNF CD40 PMC2833524 134182 Positive_regulation TNF CD40 PMC2833524 134189 Positive_regulation TNF CD40LG 11854362 1522987 Positive_regulation TNF CD40LG 14568985 1529374 Positive_regulation TNF CD40LG 18373845 3116742 Positive_regulation TNF CD40LG 18718031 111110 Positive_regulation TNF CD40LG 19956549 2432033 Positive_regulation TNF CD40LG 20104491 808106 Positive_regulation TNF CD40LG 20429874 1656231 Positive_regulation TNF CD40LG 21689404 3119734 Positive_regulation TNF CD40LG 23837669 128441 Positive_regulation TNF CD40LG 23970926 638394 Positive_regulation TNF CD40LG 23986761 908673 Positive_regulation TNF CD40LG 25161698 803826 Positive_regulation TNF CD40LG 7688031 1591559 Positive_regulation TNF CD40LG 7688031 1591563 Positive_regulation TNF CD40LG 7688031 1591564 Positive_regulation TNF CD44 8386742 1595091 Positive_regulation TNF CD46 21494626 2513387 Positive_regulation TNF CD48 16684368 105992 Positive_regulation TNF CD55 24880953 1644591 Positive_regulation TNF CD58 8554971 445086 Positive_regulation TNF CD6 22340283 660184 Positive_regulation TNF CD6 22340283 660185 Positive_regulation TNF CD69 PMC3300928 660907 Positive_regulation TNF CD79A 10523603 1512481 Positive_regulation TNF CD79A 17993753 1703966 Positive_regulation TNF CD79A 18475715 1745518 Positive_regulation TNF CD79A 19210794 365553 Positive_regulation TNF CD79A 21781305 247863 Positive_regulation TNF CD79A 22451718 1567876 Positive_regulation TNF CD79B 21931843 2555039 Positive_regulation TNF CD79B 21931843 2555040 Positive_regulation TNF CD80 22951585 1035626 Positive_regulation TNF CD86 22951585 1035627 Positive_regulation TNF CD86 25071777 913389 Positive_regulation TNF CD8A 11293812 702196 Positive_regulation TNF CD8A 17616976 3039682 Positive_regulation TNF CD8A 17678538 351928 Positive_regulation TNF CD8A 20711433 2459091 Positive_regulation TNF CD8A 23658704 2789805 Positive_regulation TNF CD8A 23658704 2789807 Positive_regulation TNF CD8A 24232179 1028939 Positive_regulation TNF CD8B 11293812 702197 Positive_regulation TNF CD8B 17616976 3039683 Positive_regulation TNF CD8B 17678538 351929 Positive_regulation TNF CD8B 23658704 2789806 Positive_regulation TNF CD9 20824074 2473605 Positive_regulation TNF CDC123 19568431 2420488 Positive_regulation TNF CDC123 19568431 2420530 Positive_regulation TNF CDC16 19568431 2420489 Positive_regulation TNF CDC16 19568431 2420531 Positive_regulation TNF CDC20 19568431 2420490 Positive_regulation TNF CDC20 19568431 2420532 Positive_regulation TNF CDC23 19568431 2420491 Positive_regulation TNF CDC23 19568431 2420533 Positive_regulation TNF CDC26 19568431 2420500 Positive_regulation TNF CDC26 19568431 2420542 Positive_regulation TNF CDC27 19568431 2420492 Positive_regulation TNF CDC27 19568431 2420534 Positive_regulation TNF CDC34 19568431 2420493 Positive_regulation TNF CDC34 19568431 2420535 Positive_regulation TNF CDC37 19568431 2420494 Positive_regulation TNF CDC37 19568431 2420536 Positive_regulation TNF CDC40 19568431 2420495 Positive_regulation TNF CDC40 19568431 2420537 Positive_regulation TNF CDC42 19568431 2420496 Positive_regulation TNF CDC42 19568431 2420538 Positive_regulation TNF CDC45 19568431 2420497 Positive_regulation TNF CDC45 19568431 2420539 Positive_regulation TNF CDC6 19568431 2420498 Positive_regulation TNF CDC6 19568431 2420540 Positive_regulation TNF CDC7 19568431 2420499 Positive_regulation TNF CDC7 19568431 2420541 Positive_regulation TNF CDC73 1460427 1529590 Positive_regulation TNF CDC73 1460427 1529597 Positive_regulation TNF CDC73 1460427 1529602 Positive_regulation TNF CDC73 1460427 1529607 Positive_regulation TNF CDC73 16172262 1537885 Positive_regulation TNF CDC73 18472926 1743167 Positive_regulation TNF CDC73 19308689 495298 Positive_regulation TNF CDC73 19568431 2420487 Positive_regulation TNF CDC73 19568431 2420529 Positive_regulation TNF CDC73 19652714 2422676 Positive_regulation TNF CDC73 21082032 2482392 Positive_regulation TNF CDC73 21860543 1749373 Positive_regulation TNF CDC73 3119758 1580163 Positive_regulation TNF CDC73 7516414 1589294 Positive_regulation TNF CDC73 9836496 1764026 Positive_regulation TNF CDCA5 23700396 1039650 Positive_regulation TNF CDCA5 24498195 2918916 Positive_regulation TNF CDH5 20308428 1373818 Positive_regulation TNF CDH5 22720111 2371291 Positive_regulation TNF CDK1 15380032 101628 Positive_regulation TNF CDK10 15380032 101630 Positive_regulation TNF CDK12 15380032 101641 Positive_regulation TNF CDK13 15380032 101629 Positive_regulation TNF CDK14 15380032 101645 Positive_regulation TNF CDK15 15380032 101627 Positive_regulation TNF CDK16 15380032 101642 Positive_regulation TNF CDK17 15380032 101643 Positive_regulation TNF CDK18 15380032 101644 Positive_regulation TNF CDK19 15380032 101639 Positive_regulation TNF CDK19 24971461 2984399 Positive_regulation TNF CDK19 7540649 1590297 Positive_regulation TNF CDK2 15380032 101631 Positive_regulation TNF CDK20 15380032 101640 Positive_regulation TNF CDK3 15380032 101632 Positive_regulation TNF CDK4 15380032 101633 Positive_regulation TNF CDK4 24302570 752147 Positive_regulation TNF CDK5 15380032 101634 Positive_regulation TNF CDK5RAP2 23554802 1226286 Positive_regulation TNF CDK6 15380032 101635 Positive_regulation TNF CDK7 15380032 101636 Positive_regulation TNF CDK8 15380032 101637 Positive_regulation TNF CDK8 24971461 2984397 Positive_regulation TNF CDK8 7540649 1590295 Positive_regulation TNF CDK9 15380032 101638 Positive_regulation TNF CDK9 22768337 2660830 Positive_regulation TNF CDKN1A 23122182 292592 Positive_regulation TNF CDL1 23755201 2801912 Positive_regulation TNF CDL1 23755201 2801919 Positive_regulation TNF CEACAM5 25258647 1240848 Positive_regulation TNF CEBPA 21314908 3209829 Positive_regulation TNF CEBPA 23843680 1753845 Positive_regulation TNF CEBPD 23725043 3207884 Positive_regulation TNF CFLAR 21307398 2174851 Positive_regulation TNF CFLAR 22348197 497091 Positive_regulation TNF CFLAR 25333625 3017584 Positive_regulation TNF CFLAR 25379355 1243449 Positive_regulation TNF CFP 23486691 1137616 Positive_regulation TNF CFP 24349220 2897188 Positive_regulation TNF CFP 24349220 2897190 Positive_regulation TNF CFTR 19847291 2429186 Positive_regulation TNF CGN 20072622 2436880 Positive_regulation TNF CGN 20072622 2436881 Positive_regulation TNF CHGA 22470519 2614504 Positive_regulation TNF CHI3L1 20029652 178132 Positive_regulation TNF CHI3L1 24729664 1758062 Positive_regulation TNF CHI3L1 24729664 1758079 Positive_regulation TNF CHI3L1 8642284 1596631 Positive_regulation TNF CHM 25053922 1627928 Positive_regulation TNF CHST4 15752429 350582 Positive_regulation TNF CHST4 15752429 350584 Positive_regulation TNF CHST4 15752429 350585 Positive_regulation TNF CHUK 15713234 3115476 Positive_regulation TNF CHUK 20221401 2442501 Positive_regulation TNF CHUK 21119000 1783907 Positive_regulation TNF CHUK 21119000 1783942 Positive_regulation TNF CHUK 21298084 2320962 Positive_regulation TNF CHUK 21298084 2320963 Positive_regulation TNF CHUK 21298084 2320971 Positive_regulation TNF CHUK 21342546 238027 Positive_regulation TNF CHUK 22701747 2652528 Positive_regulation TNF CHUK 22704338 640103 Positive_regulation TNF CHUK 22848449 2669102 Positive_regulation TNF CHUK 23144925 2714925 Positive_regulation TNF CHUK 24911653 152850 Positive_regulation TNF CHUK 25762184 1623423 Positive_regulation TNF CHUK 25762184 1623430 Positive_regulation TNF CHUK 9841930 1604790 Positive_regulation TNF CIDEA 17472743 656542 Positive_regulation TNF CIDEA 17472743 656544 Positive_regulation TNF CIRBP 24904669 95972 Positive_regulation TNF CISH 24151497 909383 Positive_regulation TNF CISH 25377316 83991 Positive_regulation TNF CKAP2L 24141950 1991008 Positive_regulation TNF CLCN3 21602838 12789 Positive_regulation TNF CLCN3 23103617 16130 Positive_regulation TNF CLCN3 23103617 16141 Positive_regulation TNF CLCN3 24850147 1883824 Positive_regulation TNF CLDN1 21853060 2542971 Positive_regulation TNF CLDN4 25031428 1828841 Positive_regulation TNF CLDN4 25096552 2252353 Positive_regulation TNF CLEC1B 23570314 1146276 Positive_regulation TNF CLEC4D 22689578 1203822 Positive_regulation TNF CLEC5A 20212065 1557456 Positive_regulation TNF CLEC5A 20212065 1557458 Positive_regulation TNF CLEC6A 19703985 1555932 Positive_regulation TNF CLEC6A 21052539 632099 Positive_regulation TNF CLEC6A 21357742 1562689 Positive_regulation TNF CLEC7A 12719478 1526929 Positive_regulation TNF CLEC7A 12719478 1526930 Positive_regulation TNF CLEC7A 12719478 1526931 Positive_regulation TNF CLEC7A 12719478 1526932 Positive_regulation TNF CLEC7A 12719478 1526934 Positive_regulation TNF CLEC7A 12719479 1526935 Positive_regulation TNF CLEC7A 15781585 1535162 Positive_regulation TNF CLEC7A 15998786 1536566 Positive_regulation TNF CLEC7A 18200499 807248 Positive_regulation TNF CLEC7A 18200499 807249 Positive_regulation TNF CLEC7A 19223162 691512 Positive_regulation TNF CLEC7A 19703985 1555867 Positive_regulation TNF CLEC7A 19703985 1555933 Positive_regulation TNF CLEC7A 22116297 1050364 Positive_regulation TNF CLEC7A 22235359 2371151 Positive_regulation TNF CLEC7A 22536422 2622432 Positive_regulation TNF CLEC7A 22566960 900524 Positive_regulation TNF CLEC7A 22577358 3056539 Positive_regulation TNF CLEC7A 23386437 1732217 Positive_regulation TNF CLEC7A 24009832 203643 Positive_regulation TNF CLEC7A 24009832 203665 Positive_regulation TNF CLEC7A 24109480 909108 Positive_regulation TNF CLEC7A 24945802 2981570 Positive_regulation TNF CLEC7A 25140116 1761039 Positive_regulation TNF CLIP3 22297296 554123 Positive_regulation TNF CLPS 24586553 2925442 Positive_regulation TNF CLPS 24676037 2946883 Positive_regulation TNF CMIP 23238132 651887 Positive_regulation TNF CNOT11 23136361 1613560 Positive_regulation TNF CNR2 23781122 1753386 Positive_regulation TNF CNR2 23781122 1753387 Positive_regulation TNF CNR2 23781122 1753390 Positive_regulation TNF CNTN2 16518473 3039115 Positive_regulation TNF CNTN2 21994759 3220098 Positive_regulation TNF COA1 24098949 295225 Positive_regulation TNF COA3 24098949 295227 Positive_regulation TNF COA4 24098949 295226 Positive_regulation TNF COA5 24098949 295228 Positive_regulation TNF COA6 24098949 295224 Positive_regulation TNF COL1A1 19298660 352656 Positive_regulation TNF COL1A1 23386906 1239760 Positive_regulation TNF COL1A2 19298660 352657 Positive_regulation TNF COL1A2 23386906 1239761 Positive_regulation TNF CPB1 23359315 2744872 Positive_regulation TNF CPB1 24386164 2902927 Positive_regulation TNF CPB1 24386164 2902931 Positive_regulation TNF CPB2 23359315 2744873 Positive_regulation TNF CPB2 24386164 2902928 Positive_regulation TNF CPB2 24386164 2902932 Positive_regulation TNF CPN1 25253920 1762379 Positive_regulation TNF CPN1 25253920 1762390 Positive_regulation TNF CPN1 25253920 1762437 Positive_regulation TNF CPOX 18955282 811117 Positive_regulation TNF CPP 23577176 2778494 Positive_regulation TNF CPP 23577176 2778500 Positive_regulation TNF CPP 23577176 2778501 Positive_regulation TNF CPP 23577176 2778505 Positive_regulation TNF CPP 23577176 2778509 Positive_regulation TNF CR1 21867543 290945 Positive_regulation TNF CREB1 12204102 3103711 Positive_regulation TNF CREB1 19381339 1746557 Positive_regulation TNF CREB1 22919361 3153831 Positive_regulation TNF CREB1 24386331 2903650 Positive_regulation TNF CREB1 24603712 2931972 Positive_regulation TNF CREB3 12204102 3103712 Positive_regulation TNF CREB3 19381339 1746558 Positive_regulation TNF CREB3 22919361 3153832 Positive_regulation TNF CREB3 24386331 2903651 Positive_regulation TNF CREB3 24603712 2931973 Positive_regulation TNF CREB5 12204102 3103710 Positive_regulation TNF CREB5 19381339 1746556 Positive_regulation TNF CREB5 22919361 3153830 Positive_regulation TNF CREB5 24386331 2903649 Positive_regulation TNF CREB5 24603712 2931971 Positive_regulation TNF CRH 22028729 633464 Positive_regulation TNF CRH 22089831 1630520 Positive_regulation TNF CRH 22089831 1630521 Positive_regulation TNF CRH 22768175 2659981 Positive_regulation TNF CRH 25537677 1654223 Positive_regulation TNF CRK 19566962 3109712 Positive_regulation TNF CRK 20070884 1852891 Positive_regulation TNF CRK 20644716 2455968 Positive_regulation TNF CRK 20676807 694238 Positive_regulation TNF CRK 21314908 3209824 Positive_regulation TNF CRK 21390243 1049696 Positive_regulation TNF CRK 23046544 3161174 Positive_regulation TNF CRK 23587438 1666553 Positive_regulation TNF CRK 24086560 2854636 Positive_regulation TNF CRK 24386331 2903528 Positive_regulation TNF CRK 24530567 1621202 Positive_regulation TNF CRK 24826069 1917008 Positive_regulation TNF CRP 17392588 1741415 Positive_regulation TNF CRP 22347541 1675376 Positive_regulation TNF CRP 22493611 1709962 Positive_regulation TNF CRP 22566859 898998 Positive_regulation TNF CRP 23299528 439759 Positive_regulation TNF CRP 24167754 1152401 Positive_regulation TNF CRY1 24901009 1621689 Positive_regulation TNF CRY2 24901009 1621690 Positive_regulation TNF CRYAA 22359280 778207 Positive_regulation TNF CRYAA 22359280 778209 Positive_regulation TNF CSE 19293939 2408186 Positive_regulation TNF CSE 19293939 2408187 Positive_regulation TNF CSE 19515231 3109649 Positive_regulation TNF CSE 21738617 2532821 Positive_regulation TNF CSE 21738617 2532880 Positive_regulation TNF CSE 22359478 1714077 Positive_regulation TNF CSE 22363418 2598901 Positive_regulation TNF CSE 24553063 2118516 Positive_regulation TNF CSE 24553063 2118517 Positive_regulation TNF CSE 24553063 2118523 Positive_regulation TNF CSE 25089961 2994796 Positive_regulation TNF CSF1 10637272 1514169 Positive_regulation TNF CSF1 11953891 421557 Positive_regulation TNF CSF1 16859503 106256 Positive_regulation TNF CSF1 16859503 106262 Positive_regulation TNF CSF1 17533390 429154 Positive_regulation TNF CSF1 18475730 1745912 Positive_regulation TNF CSF1 1911209 431528 Positive_regulation TNF CSF1 1911209 431542 Positive_regulation TNF CSF1 19642998 1616290 Positive_regulation TNF CSF1 21324111 121496 Positive_regulation TNF CSF1 2183871 437475 Positive_regulation TNF CSF1 22249448 1566915 Positive_regulation TNF CSF1 22249448 1566916 Positive_regulation TNF CSF1 22563430 2626506 Positive_regulation TNF CSF1 23110133 2706592 Positive_regulation TNF CSF1 23762085 637599 Positive_regulation TNF CSF1 24019592 3079927 Positive_regulation TNF CSF1 24470972 1049868 Positive_regulation TNF CSF1 24839444 1144940 Positive_regulation TNF CSF1 2509625 1577153 Positive_regulation TNF CSF1 2526848 1577256 Positive_regulation TNF CSF1 3263464 1580715 Positive_regulation TNF CSF1 8691150 1598523 Positive_regulation TNF CSF1R 20181277 118369 Positive_regulation TNF CSF1R 20181277 118370 Positive_regulation TNF CSF1R 20181277 118373 Positive_regulation TNF CSF2 11132773 1737260 Positive_regulation TNF CSF2 11132773 1737261 Positive_regulation TNF CSF2 11953891 421558 Positive_regulation TNF CSF2 15857511 648867 Positive_regulation TNF CSF2 1643416 702434 Positive_regulation TNF CSF2 18360651 3176744 Positive_regulation TNF CSF2 18437014 1635013 Positive_regulation TNF CSF2 18437014 1635014 Positive_regulation TNF CSF2 18437014 1635015 Positive_regulation TNF CSF2 18472817 1741766 Positive_regulation TNF CSF2 18779348 1551911 Positive_regulation TNF CSF2 18947379 111830 Positive_regulation TNF CSF2 19686583 116572 Positive_regulation TNF CSF2 1972179 1556149 Positive_regulation TNF CSF2 2007858 1557269 Positive_regulation TNF CSF2 21079906 1644329 Positive_regulation TNF CSF2 21106069 1621033 Positive_regulation TNF CSF2 2165128 1564032 Positive_regulation TNF CSF2 2183871 437476 Positive_regulation TNF CSF2 23234315 1665483 Positive_regulation TNF CSF2 23234315 1665497 Positive_regulation TNF CSF2 23234315 1665498 Positive_regulation TNF CSF2 23352035 1506683 Positive_regulation TNF CSF2 23554905 2773628 Positive_regulation TNF CSF2 23586068 181389 Positive_regulation TNF CSF2 24040434 2372090 Positive_regulation TNF CSF2 24446489 1574662 Positive_regulation TNF CSF2 24744763 912250 Positive_regulation TNF CSF2 24839444 1144941 Positive_regulation TNF CSF2 24995121 652238 Positive_regulation TNF CSF2 25061260 1760231 Positive_regulation TNF CSF2 2538549 1577291 Positive_regulation TNF CSF2 25387665 1050600 Positive_regulation TNF CSF2 25387665 1050603 Positive_regulation TNF CSF2 25506346 921517 Positive_regulation TNF CSF2 2647480 795281 Positive_regulation TNF CSF2 2647480 795282 Positive_regulation TNF CSF2 2659724 1577672 Positive_regulation TNF CSF2 3049617 1425610 Positive_regulation TNF CSF2 3049913 1579815 Positive_regulation TNF CSF2 3351436 1581113 Positive_regulation TNF CSF2 7688031 1591551 Positive_regulation TNF CSF2 8006603 1593767 Positive_regulation TNF CSF2 8382509 444842 Positive_regulation TNF CSF2 8478614 1595506 Positive_regulation TNF CSF2 8478614 1595562 Positive_regulation TNF CSF2 8676060 1597695 Positive_regulation TNF CSF3 1375270 1528770 Positive_regulation TNF CSF3 19886984 659369 Positive_regulation TNF CSF3 7686211 1591501 Positive_regulation TNF CSK 19966777 1960920 Positive_regulation TNF CSK 20846396 353600 Positive_regulation TNF CSK 21085613 3049983 Positive_regulation TNF CSK 21931706 2554187 Positive_regulation TNF CSK 22556042 1050668 Positive_regulation TNF CSK 24205328 2875986 Positive_regulation TNF CSK 24205328 2875987 Positive_regulation TNF CSK 24205328 2876012 Positive_regulation TNF CSK 24205328 2876013 Positive_regulation TNF CSK 24205328 2876063 Positive_regulation TNF CSK 24205328 2876072 Positive_regulation TNF CSK 24349012 2896567 Positive_regulation TNF CSK 24349012 2896597 Positive_regulation TNF CSK 24349012 2896598 Positive_regulation TNF CSK 24489933 2916959 Positive_regulation TNF CSK 24567720 953584 Positive_regulation TNF CSK 25057505 1622501 Positive_regulation TNF CSK 25057505 1622540 Positive_regulation TNF CSK 25531754 3035274 Positive_regulation TNF CSN2 20594364 465942 Positive_regulation TNF CSPG4 18715114 2369403 Positive_regulation TNF CSPG5 18715114 2369404 Positive_regulation TNF CSRP1 15456513 3177966 Positive_regulation TNF CSRP1 17704137 2028976 Positive_regulation TNF CSRP1 22192852 124466 Positive_regulation TNF CSRP1 22566859 898995 Positive_regulation TNF CSRP1 23066303 1681788 Positive_regulation TNF CSRP1 23946727 695940 Positive_regulation TNF CSRP1 24381940 186051 Positive_regulation TNF CST3 21253577 3050845 Positive_regulation TNF CTDP1 21298084 2320981 Positive_regulation TNF CTGF 19922639 117855 Positive_regulation TNF CTR9 1460427 1529591 Positive_regulation TNF CTR9 1460427 1529598 Positive_regulation TNF CTR9 1460427 1529603 Positive_regulation TNF CTR9 1460427 1529608 Positive_regulation TNF CTR9 16172262 1537886 Positive_regulation TNF CTR9 18472926 1743168 Positive_regulation TNF CTR9 19308689 495299 Positive_regulation TNF CTR9 19652714 2422677 Positive_regulation TNF CTR9 21082032 2482393 Positive_regulation TNF CTR9 21860543 1749374 Positive_regulation TNF CTR9 3119758 1580164 Positive_regulation TNF CTR9 7516414 1589295 Positive_regulation TNF CTR9 9836496 1764027 Positive_regulation TNF CTSB 11381085 1270273 Positive_regulation TNF CTSG 21569464 1697264 Positive_regulation TNF CTSS 11381085 1270274 Positive_regulation TNF CTSS 22844403 2668029 Positive_regulation TNF CUL1 21559359 2518415 Positive_regulation TNF CUX1 23805228 2807920 Positive_regulation TNF CX3CL1 18710591 111071 Positive_regulation TNF CX3CL1 22566871 899072 Positive_regulation TNF CX3CL1 22943205 645668 Positive_regulation TNF CX3CL1 23800251 1627056 Positive_regulation TNF CX3CL1 23914058 1694359 Positive_regulation TNF CX3CL1 24995121 652237 Positive_regulation TNF CX3CR1 22566871 899069 Positive_regulation TNF CXCL1 19934004 711849 Positive_regulation TNF CXCL1 23300534 2733677 Positive_regulation TNF CXCL1 24580964 1667718 Positive_regulation TNF CXCL1 24580964 1667719 Positive_regulation TNF CXCL1 24580964 1667732 Positive_regulation TNF CXCL1 24926881 2979840 Positive_regulation TNF CXCL1 25100435 2118917 Positive_regulation TNF CXCL10 16033640 3105153 Positive_regulation TNF CXCL10 16846531 106217 Positive_regulation TNF CXCL10 19582151 2420924 Positive_regulation TNF CXCL10 19934004 711840 Positive_regulation TNF CXCL10 20495997 598964 Positive_regulation TNF CXCL10 21508508 736866 Positive_regulation TNF CXCL10 21853018 2542824 Positive_regulation TNF CXCL10 22022590 2563979 Positive_regulation TNF CXCL10 22022590 2563986 Positive_regulation TNF CXCL10 22110387 1058544 Positive_regulation TNF CXCL10 22387292 84437 Positive_regulation TNF CXCL10 23034049 3113190 Positive_regulation TNF CXCL10 23800251 1627055 Positive_regulation TNF CXCL10 24648846 1156528 Positive_regulation TNF CXCL11 16033640 3105154 Positive_regulation TNF CXCL11 19934004 711841 Positive_regulation TNF CXCL12 17047310 1212356 Positive_regulation TNF CXCL12 18371213 110355 Positive_regulation TNF CXCL12 19804625 117455 Positive_regulation TNF CXCL12 19934004 711846 Positive_regulation TNF CXCL12 25774937 134113 Positive_regulation TNF CXCL13 19934004 711842 Positive_regulation TNF CXCL14 19934004 711843 Positive_regulation TNF CXCL16 19690611 2424217 Positive_regulation TNF CXCL16 19934004 711847 Positive_regulation TNF CXCL16 24130892 2867520 Positive_regulation TNF CXCL16 24130892 2867528 Positive_regulation TNF CXCL17 19934004 711848 Positive_regulation TNF CXCL2 19934004 711850 Positive_regulation TNF CXCL2 21845170 1076842 Positive_regulation TNF CXCL3 19934004 711851 Positive_regulation TNF CXCL5 19934004 711844 Positive_regulation TNF CXCL6 19686583 116571 Positive_regulation TNF CXCL6 19934004 711845 Positive_regulation TNF CXCL9 16033640 3105155 Positive_regulation TNF CXCL9 19934004 711854 Positive_regulation TNF CXCL9 19934004 711865 Positive_regulation TNF CXCL9 21853018 2542825 Positive_regulation TNF CXCR2 24613851 701443 Positive_regulation TNF CXCR4 16109172 3115867 Positive_regulation TNF CXCR4 22661970 876639 Positive_regulation TNF CXCR4 23986795 2220466 Positive_regulation TNF CXCR4 25196285 3224102 Positive_regulation TNF CXCR4 25527973 1736359 Positive_regulation TNF CXCR6 19690611 2424218 Positive_regulation TNF CYBA 20716913 2222562 Positive_regulation TNF CYBB 20421951 3046681 Positive_regulation TNF CYBB 23451244 2758435 Positive_regulation TNF CYBB 8102388 1594063 Positive_regulation TNF CYCS 21298033 2499370 Positive_regulation TNF CYCS 24817082 2963255 Positive_regulation TNF CYP19A1 19809499 2427886 Positive_regulation TNF CYP2E1 20979658 1723394 Positive_regulation TNF CYP2E1 24192824 1121481 Positive_regulation TNF DAXX 22111877 334699 Positive_regulation TNF DDIT3 24963104 1159868 Positive_regulation TNF DDX41 23062757 1030130 Positive_regulation TNF DDX58 18617992 3041611 Positive_regulation TNF DDX58 18617992 3041612 Positive_regulation TNF DDX58 18617992 3041613 Positive_regulation TNF DDX58 18617992 3041614 Positive_regulation TNF DDX58 18617992 3041653 Positive_regulation TNF DDX58 18617992 3041664 Positive_regulation TNF DECR2 22769054 356005 Positive_regulation TNF DEFA1B 20525314 119114 Positive_regulation TNF DEFA1B 20525314 119115 Positive_regulation TNF DEFA1B 24274254 1728474 Positive_regulation TNF DEFB103B 20104491 808098 Positive_regulation TNF DEFB103B 20104491 808099 Positive_regulation TNF DEFB103B 21809339 808417 Positive_regulation TNF DERL1 19193236 365523 Positive_regulation TNF DHX58 24455433 3151145 Positive_regulation TNF DIABLO 21738708 2533449 Positive_regulation TNF DIABLO 23990022 564999 Positive_regulation TNF DIS3 23658846 2371891 Positive_regulation TNF DKK1 19497136 113472 Positive_regulation TNF DKK1 21438671 6601 Positive_regulation TNF DKK1 22477520 694250 Positive_regulation TNF DKK1 23509994 380253 Positive_regulation TNF DKK1 24250816 2881722 Positive_regulation TNF DKK1 24592264 911242 Positive_regulation TNF DKK1 PMC3007788 1702491 Positive_regulation TNF DKK3 24286133 130359 Positive_regulation TNF DKK4 24286133 130360 Positive_regulation TNF DLL1 22190977 633863 Positive_regulation TNF DLL3 22190977 633864 Positive_regulation TNF DNAJC5 23300801 2736004 Positive_regulation TNF DNMT3B 25195642 2118934 Positive_regulation TNF DOK3 22761938 2659382 Positive_regulation TNF DPM1 24152138 1232654 Positive_regulation TNF DPM2 24152138 1232655 Positive_regulation TNF DPM3 24152138 1232656 Positive_regulation TNF DPP4 23805228 2807938 Positive_regulation TNF DPP4 24920931 731595 Positive_regulation TNF DPP4 24920931 731601 Positive_regulation TNF DUSP1 24367207 1028537 Positive_regulation TNF DUSP1 24842373 1576395 Positive_regulation TNF DUSP4 21085614 3050041 Positive_regulation TNF DYNLRB1 22808176 2664961 Positive_regulation TNF DYNLRB1 23638011 2786959 Positive_regulation TNF DYNLRB1 23638011 2786989 Positive_regulation TNF EBI3 22438968 2612427 Positive_regulation TNF EBI3 22438968 2612433 Positive_regulation TNF ECM1 20843335 1626165 Positive_regulation TNF ECM1 22353555 166519 Positive_regulation TNF ECM1 24312190 2888257 Positive_regulation TNF ECM2 20843335 1626166 Positive_regulation TNF ECM2 22353555 166520 Positive_regulation TNF ECM2 24312190 2888258 Positive_regulation TNF EDA 15946381 3105038 Positive_regulation TNF EDN1 17137491 379209 Positive_regulation TNF EDN1 17497041 1741463 Positive_regulation TNF EDN1 18195069 1548370 Positive_regulation TNF EDN1 18416854 2111295 Positive_regulation TNF EDN1 18475471 1743885 Positive_regulation TNF EDN1 18475557 1744319 Positive_regulation TNF EDN1 18475557 1744322 Positive_regulation TNF EDN1 21627837 1658456 Positive_regulation TNF EDN1 24130926 204544 Positive_regulation TNF EDN1 24395887 1574421 Positive_regulation TNF EDN2 18195069 1548371 Positive_regulation TNF EDN3 18195069 1548372 Positive_regulation TNF EDNRB 24557580 1123953 Positive_regulation TNF EFNA1 20224755 1672019 Positive_regulation TNF EGFR 11686870 3102969 Positive_regulation TNF EGFR 15841081 425858 Positive_regulation TNF EGFR 23389627 1811752 Positive_regulation TNF EGFR 23389627 1811916 Positive_regulation TNF EGFR 23651618 3085070 Positive_regulation TNF EGFR 23878744 1150824 Positive_regulation TNF EGFR 23878744 1150834 Positive_regulation TNF EGFR 23905066 3188198 Positive_regulation TNF EGFR 25356505 1132679 Positive_regulation TNF EGFR 25398130 3027510 Positive_regulation TNF EGFR PMC2364207 449991 Positive_regulation TNF EGFR PMC4288433 1623796 Positive_regulation TNF EGR1 15142264 101182 Positive_regulation TNF EGR1 15545056 1739770 Positive_regulation TNF EGR1 21736731 1898349 Positive_regulation TNF EGR1 25004251 2195478 Positive_regulation TNF EGR1 25502753 3033874 Positive_regulation TNF EIF2AK2 14979937 100113 Positive_regulation TNF EIF2AK2 14979937 100114 Positive_regulation TNF EIF2AK2 14979937 100115 Positive_regulation TNF EIF2AK2 14979937 100181 Positive_regulation TNF EIF2AK2 22174864 2582385 Positive_regulation TNF EIF2AK2 23990781 3063841 Positive_regulation TNF EIF2AK2 23990781 3063849 Positive_regulation TNF EIF4E 1658188 1539827 Positive_regulation TNF ELANE 22570765 1680687 Positive_regulation TNF ELAVL1 23028373 2338514 Positive_regulation TNF ELAVL1 24884781 357577 Positive_regulation TNF ELL 22391038 1396091 Positive_regulation TNF ELSPBP1 20016738 2114386 Positive_regulation TNF ENPP2 20356387 1853839 Positive_regulation TNF ENPP2 21765444 13146 Positive_regulation TNF EPAS1 24520300 2167685 Positive_regulation TNF EPHB2 11136824 1518275 Positive_regulation TNF EPHB2 17567906 370614 Positive_regulation TNF EPHB2 17888187 1848159 Positive_regulation TNF EPHB2 19476641 1897206 Positive_regulation TNF EPHB2 19476641 1897213 Positive_regulation TNF EPHB2 19476641 1897220 Positive_regulation TNF EPHB2 19566962 3109723 Positive_regulation TNF EPHB2 20644716 2455938 Positive_regulation TNF EPHB2 20644716 2455969 Positive_regulation TNF EPHB2 20830230 1711852 Positive_regulation TNF EPHB2 21317295 717816 Positive_regulation TNF EPHB2 21317295 717823 Positive_regulation TNF EPHB2 21317295 717897 Positive_regulation TNF EPHB2 21317295 717898 Positive_regulation TNF EPHB2 21317295 717917 Positive_regulation TNF EPHB2 21317295 717928 Positive_regulation TNF EPHB2 21317295 717937 Positive_regulation TNF EPHB2 22384111 2604294 Positive_regulation TNF EPHB2 22384111 2605943 Positive_regulation TNF EPHB2 22455317 3210183 Positive_regulation TNF EPHB2 22909087 1626657 Positive_regulation TNF EPHB2 23227067 3204581 Positive_regulation TNF EPHB2 23389627 1811753 Positive_regulation TNF EPHB2 23389627 1811754 Positive_regulation TNF EPHB2 23389627 1811951 Positive_regulation TNF EPHB2 23555735 2775000 Positive_regulation TNF EPHB2 23651618 3085071 Positive_regulation TNF EPHB2 23878744 1150830 Positive_regulation TNF EPHB2 23936328 2829941 Positive_regulation TNF EPHB2 24191131 1755000 Positive_regulation TNF EPHB2 24386331 2903529 Positive_regulation TNF EPHB2 24404333 206102 Positive_regulation TNF EPHB2 24421891 2909239 Positive_regulation TNF EPHB2 24722253 2951096 Positive_regulation TNF EPHB2 24826069 1917009 Positive_regulation TNF EPHB2 9400710 797301 Positive_regulation TNF EPO 22394384 1661315 Positive_regulation TNF EPO 25170305 1063327 Positive_regulation TNF EPS15 21559529 2520176 Positive_regulation TNF EPS15 25625033 212542 Positive_regulation TNF EPS8 21559529 2520177 Positive_regulation TNF EPS8 25625033 212543 Positive_regulation TNF ERBB2 21386087 718837 Positive_regulation TNF ERBB2 22482061 1065182 Positive_regulation TNF ERBB3 21386087 718838 Positive_regulation TNF EREG 20161853 1043916 Positive_regulation TNF ERN1 22474423 832828 Positive_regulation TNF ERN1 22570745 1024138 Positive_regulation TNF ERN1 24918756 2979296 Positive_regulation TNF ERP27 24385881 3155726 Positive_regulation TNF ERP29 24385881 3155724 Positive_regulation TNF ERP44 24385881 3155725 Positive_regulation TNF ERVK-6 24453410 1756626 Positive_regulation TNF ESAT 22523581 2620384 Positive_regulation TNF ESAT 22523581 2620424 Positive_regulation TNF ESAT 24260295 2883659 Positive_regulation TNF ETF1 10339451 789286 Positive_regulation TNF EXOSC1 23658846 2371887 Positive_regulation TNF EXOSC2 23658846 2371886 Positive_regulation TNF EXOSC3 23658846 2371888 Positive_regulation TNF EXOSC4 23658846 2371889 Positive_regulation TNF EXOSC5 23658846 2371892 Positive_regulation TNF EXOSC6 23658846 2371890 Positive_regulation TNF EXOSC7 23658846 2371893 Positive_regulation TNF EXOSC8 23658846 2371885 Positive_regulation TNF EXOSC9 23658846 2371894 Positive_regulation TNF F12 22952837 2684252 Positive_regulation TNF F2 24728278 2951812 Positive_regulation TNF F2R 24453410 1756645 Positive_regulation TNF F2RL1 16571116 1624879 Positive_regulation TNF F2RL1 23935250 1754421 Positive_regulation TNF F2RL1 24009835 203685 Positive_regulation TNF FADD 17567906 370636 Positive_regulation TNF FADD 25431611 827036 Positive_regulation TNF FAH 1911180 431518 Positive_regulation TNF FAH 2257222 438739 Positive_regulation TNF FAH 9413946 446774 Positive_regulation TNF FAH 9703279 447534 Positive_regulation TNF FANCD2 21912593 2552135 Positive_regulation TNF FAS 10209037 1511460 Positive_regulation TNF FAS 10684857 1514494 Positive_regulation TNF FAS 11581316 1521081 Positive_regulation TNF FAS 11581316 1521096 Positive_regulation TNF FAS 11581316 1521101 Positive_regulation TNF FAS 17764548 108945 Positive_regulation TNF FAS 20565784 1626084 Positive_regulation TNF FAS 20565784 1626086 Positive_regulation TNF FAS 22707768 1044061 Positive_regulation TNF FAS 23191987 357286 Positive_regulation TNF FAS 23259092 514989 Positive_regulation TNF FAS 23762085 637540 Positive_regulation TNF FAS 23762085 637570 Positive_regulation TNF FAS 23967134 2834611 Positive_regulation TNF FAS 25028665 194804 Positive_regulation TNF FASLG 10209037 1511461 Positive_regulation TNF FASLG 20529219 34670 Positive_regulation TNF FASLG 23259092 514990 Positive_regulation TNF FASLG 23762085 637541 Positive_regulation TNF FASLG 24667392 2938708 Positive_regulation TNF FASLG 9126933 1601098 Positive_regulation TNF FCER2 19279679 2407855 Positive_regulation TNF FCER2 19279679 2407863 Positive_regulation TNF FCER2 21526166 2513810 Positive_regulation TNF FCER2 21526166 2513812 Positive_regulation TNF FCER2 21526166 2513813 Positive_regulation TNF FCGR3A 11850593 1632894 Positive_regulation TNF FCGR3A 2137855 1562723 Positive_regulation TNF FCGR3A 2831292 1578484 Positive_regulation TNF FCGR3B 11781363 1522115 Positive_regulation TNF FCGR3B 2536067 1577275 Positive_regulation TNF FCGR3B 7650486 1591363 Positive_regulation TNF FCGRT 20886282 1491451 Positive_regulation TNF FCN2 24040095 2845648 Positive_regulation TNF FGB 21234322 1064126 Positive_regulation TNF FGB 22655214 1052863 Positive_regulation TNF FGB 23208413 2110581 Positive_regulation TNF FGB 3411290 1581147 Positive_regulation TNF FGB PMC3332409 134759 Positive_regulation TNF FGF2 21756372 3112399 Positive_regulation TNF FGFR3 22723832 2654741 Positive_regulation TNF FGFR3 24914105 1684422 Positive_regulation TNF FIGF 23243599 2161896 Positive_regulation TNF FLT4 24124909 1667200 Positive_regulation TNF FN1 18053242 1695764 Positive_regulation TNF FOS 20504330 329091 Positive_regulation TNF FOS 23173923 381108 Positive_regulation TNF FOS 23674902 629803 Positive_regulation TNF FOS 23805228 2807921 Positive_regulation TNF FOS 24386331 2903530 Positive_regulation TNF FOSB 15142264 101166 Positive_regulation TNF FOSL2 15142264 101167 Positive_regulation TNF FOXN1 17922571 3039933 Positive_regulation TNF FOXO1 20300563 1910601 Positive_regulation TNF FOXO1 22454632 832687 Positive_regulation TNF FOXO1 24864265 191762 Positive_regulation TNF FOXP3 23077634 2705065 Positive_regulation TNF FOXP3 24193319 3138592 Positive_regulation TNF FSCN1 24857932 2973155 Positive_regulation TNF FSCN1 24857932 2973161 Positive_regulation TNF FSCN1 24857932 2973163 Positive_regulation TNF FSCN1 25120576 826623 Positive_regulation TNF FSCN1 7519237 1589359 Positive_regulation TNF FSTL1 18195069 1548429 Positive_regulation TNF FSTL1 19966777 1960921 Positive_regulation TNF FSTL1 20404927 2446598 Positive_regulation TNF FSTL1 21931706 2554185 Positive_regulation TNF FSTL1 24347831 1755780 Positive_regulation TNF FSTL1 24347831 1755781 Positive_regulation TNF FSTL1 24347831 1755798 Positive_regulation TNF FSTL1 24347831 1755864 Positive_regulation TNF FSTL1 24743542 2955599 Positive_regulation TNF FSTL1 25093709 34344 Positive_regulation TNF FUT1 25352951 987230 Positive_regulation TNF FXYD1 24367694 2900578 Positive_regulation TNF FXYD1 24367694 2900582 Positive_regulation TNF FXYD1 24367694 2900583 Positive_regulation TNF FXYD1 24367694 2900584 Positive_regulation TNF FXYD1 24367694 2900586 Positive_regulation TNF FXYD1 24367694 2900587 Positive_regulation TNF FXYD1 24367694 2900589 Positive_regulation TNF FXYD1 24367694 2900591 Positive_regulation TNF FXYD1 24367694 2900595 Positive_regulation TNF FYB 22672517 532753 Positive_regulation TNF FYN 19888448 2430222 Positive_regulation TNF FYN 19888448 2430223 Positive_regulation TNF FYN 23008778 1151606 Positive_regulation TNF FZD5 21857966 2544451 Positive_regulation TNF GABPA 24406502 3139201 Positive_regulation TNF GAD2 23863909 730171 Positive_regulation TNF GADD45A 22253905 2588319 Positive_regulation TNF GADD45G 25248126 3009304 Positive_regulation TNF GADD45G 25248126 3009306 Positive_regulation TNF GAL 14960194 656454 Positive_regulation TNF GAL 19936071 2370602 Positive_regulation TNF GAL 20877724 2475609 Positive_regulation TNF GAL 23762040 980674 Positive_regulation TNF GAL 24554039 453634 Positive_regulation TNF GAL 24772178 825599 Positive_regulation TNF GAST 22719247 3057136 Positive_regulation TNF GAST 23166526 1021751 Positive_regulation TNF GBP1 22692453 1918874 Positive_regulation TNF GC 22225630 124574 Positive_regulation TNF GC 22225630 124578 Positive_regulation TNF GC 22225630 124580 Positive_regulation TNF GCG 3351436 1581116 Positive_regulation TNF GCHFR 21736731 1898350 Positive_regulation TNF GDF10 19617892 7915 Positive_regulation TNF GFAP 24330827 1667473 Positive_regulation TNF GH1 24524669 131935 Positive_regulation TNF GHITM 21909400 2551984 Positive_regulation TNF GIF 18472955 1743373 Positive_regulation TNF GIF 24130892 2867521 Positive_regulation TNF GIF 24648814 1712220 Positive_regulation TNF GIF 24799891 980928 Positive_regulation TNF GIF 25025040 194659 Positive_regulation TNF GIF 8318425 444695 Positive_regulation TNF GJA1 22096383 1030533 Positive_regulation TNF GLA 22829921 2667896 Positive_regulation TNF GLA 23393601 2751376 Positive_regulation TNF GLA 24168453 1726384 Positive_regulation TNF GLS 22534375 125570 Positive_regulation TNF GLYCAM1 22880094 2674206 Positive_regulation TNF GNRH1 24182325 3129591 Positive_regulation TNF GNRH1 24622841 3081754 Positive_regulation TNF GOLGA4 24566136 1124063 Positive_regulation TNF GORASP1 19893201 736343 Positive_regulation TNF GOT2 15770048 1739929 Positive_regulation TNF GP2 19434244 646156 Positive_regulation TNF GP2 23807159 2171413 Positive_regulation TNF GP2 25075740 2993140 Positive_regulation TNF GP5 19434244 646157 Positive_regulation TNF GP5 23807159 2171414 Positive_regulation TNF GP5 25075740 2993142 Positive_regulation TNF GP6 19434244 646155 Positive_regulation TNF GP6 23807159 2171412 Positive_regulation TNF GP9 19434244 646158 Positive_regulation TNF GP9 23807159 2171415 Positive_regulation TNF GPBAR1 24755711 2957310 Positive_regulation TNF GPBAR1 24755711 2957319 Positive_regulation TNF GPBAR1 24755711 2957324 Positive_regulation TNF GPBAR1 24755711 2957331 Positive_regulation TNF GPBAR1 24755711 2957336 Positive_regulation TNF GPC3 24992906 2171772 Positive_regulation TNF GPI 18534002 110951 Positive_regulation TNF GPI 18534002 110952 Positive_regulation TNF GPI 20193084 1727968 Positive_regulation TNF GPI 22131998 1703261 Positive_regulation TNF GPI 22518279 1079940 Positive_regulation TNF GPI 8418196 1595139 Positive_regulation TNF GRAP2 20615213 119566 Positive_regulation TNF GRAP2 21317295 717817 Positive_regulation TNF GRAP2 21317295 717824 Positive_regulation TNF GRAP2 21317295 717900 Positive_regulation TNF GRAP2 21317295 717929 Positive_regulation TNF GRAP2 21317295 717938 Positive_regulation TNF GRAP2 21682898 122920 Positive_regulation TNF GRAP2 23227067 3204582 Positive_regulation TNF GRAP2 23326086 1162760 Positive_regulation TNF GRAP2 23468959 2760292 Positive_regulation TNF GRAP2 23587438 1666537 Positive_regulation TNF GRAP2 24278357 2885800 Positive_regulation TNF GRAP2 24629023 1701462 Positive_regulation TNF GRAP2 24743742 573779 Positive_regulation TNF GRAP2 24916922 1668188 Positive_regulation TNF GRM2 24768662 3102639 Positive_regulation TNF GRN 16030389 1740017 Positive_regulation TNF GTF2B 21298084 2320982 Positive_regulation TNF GTF2B 8666922 1597185 Positive_regulation TNF GTF2F1 21298084 2320983 Positive_regulation TNF GTF2F2 21298084 2320984 Positive_regulation TNF GTS 21843370 1659408 Positive_regulation TNF GYS1 21188217 1081615 Positive_regulation TNF GYS2 21188217 1081616 Positive_regulation TNF GZMA 23326234 3060350 Positive_regulation TNF HAMP 22998440 1231261 Positive_regulation TNF HAVCR2 23144609 3059992 Positive_regulation TNF HAVCR2 23450201 906146 Positive_regulation TNF HAVCR2 24289479 1667387 Positive_regulation TNF HAVCR2 25375372 578813 Positive_regulation TNF HCLS1 15996269 1624738 Positive_regulation TNF HCLS1 8666940 1597388 Positive_regulation TNF HCLS1 9348317 1601932 Positive_regulation TNF HDAC1 15899037 103368 Positive_regulation TNF HDAC1 21234331 1218421 Positive_regulation TNF HDAC1 22413888 1661338 Positive_regulation TNF HDAC1 7931061 1593043 Positive_regulation TNF HDAC10 22413888 1661336 Positive_regulation TNF HDAC11 22413888 1661337 Positive_regulation TNF HDAC2 15899037 103369 Positive_regulation TNF HDAC2 21234331 1218422 Positive_regulation TNF HDAC2 22413888 1661339 Positive_regulation TNF HDAC2 7931061 1593044 Positive_regulation TNF HDAC3 22413888 1661340 Positive_regulation TNF HDAC3 23559860 1915760 Positive_regulation TNF HDAC4 22413888 1661331 Positive_regulation TNF HDAC4 24086512 2854451 Positive_regulation TNF HDAC4 25187650 1830469 Positive_regulation TNF HDAC4 25187650 1830491 Positive_regulation TNF HDAC5 22413888 1661335 Positive_regulation TNF HDAC6 22413888 1661332 Positive_regulation TNF HDAC7 22413888 1661334 Positive_regulation TNF HDAC8 22413888 1661330 Positive_regulation TNF HDAC9 22413888 1661333 Positive_regulation TNF HES1 21242294 1562401 Positive_regulation TNF HGF 20161853 1043917 Positive_regulation TNF HIF1A 24416312 2907609 Positive_regulation TNF HIST1H4E 15197227 1532973 Positive_regulation TNF HLA-A 19802382 2427599 Positive_regulation TNF HLA-B 15987495 104027 Positive_regulation TNF HLA-DRA 16356195 104876 Positive_regulation TNF HLA-DRA 21283748 2497636 Positive_regulation TNF HLA-DRA 9236189 1601332 Positive_regulation TNF HLA-DRB1 16356195 104877 Positive_regulation TNF HLA-DRB1 17592646 250172 Positive_regulation TNF HLA-DRB1 21283748 2497637 Positive_regulation TNF HLA-DRB1 23191987 357287 Positive_regulation TNF HLA-DRB1 9236189 1601333 Positive_regulation TNF HLA-E 23226431 2724751 Positive_regulation TNF HLA-G 24839609 1621571 Positive_regulation TNF HMGB1 10952726 1516712 Positive_regulation TNF HMGB1 10952726 1516713 Positive_regulation TNF HMGB1 10952726 1516714 Positive_regulation TNF HMGB1 10952726 1516715 Positive_regulation TNF HMGB1 15795240 1535298 Positive_regulation TNF HMGB1 16480493 290856 Positive_regulation TNF HMGB1 17397533 108191 Positive_regulation TNF HMGB1 17903310 658862 Positive_regulation TNF HMGB1 17987129 2380507 Positive_regulation TNF HMGB1 18288272 1741537 Positive_regulation TNF HMGB1 18346273 110177 Positive_regulation TNF HMGB1 18346273 110180 Positive_regulation TNF HMGB1 18346273 110184 Positive_regulation TNF HMGB1 18346273 110185 Positive_regulation TNF HMGB1 18557992 110961 Positive_regulation TNF HMGB1 19064698 1553023 Positive_regulation TNF HMGB1 19799777 3110063 Positive_regulation TNF HMGB1 20379370 1214267 Positive_regulation TNF HMGB1 20379370 1214268 Positive_regulation TNF HMGB1 21040547 1657243 Positive_regulation TNF HMGB1 21365018 1912723 Positive_regulation TNF HMGB1 21406085 313376 Positive_regulation TNF HMGB1 21406085 313377 Positive_regulation TNF HMGB1 21406085 313381 Positive_regulation TNF HMGB1 21406085 313383 Positive_regulation TNF HMGB1 21507210 3129600 Positive_regulation TNF HMGB1 21532866 1635366 Positive_regulation TNF HMGB1 21532866 1635367 Positive_regulation TNF HMGB1 21810260 1697631 Positive_regulation TNF HMGB1 21871094 123894 Positive_regulation TNF HMGB1 21989210 1659943 Positive_regulation TNF HMGB1 22096364 1628325 Positive_regulation TNF HMGB1 22370717 1567462 Positive_regulation TNF HMGB1 22563397 2626266 Positive_regulation TNF HMGB1 22563397 2626270 Positive_regulation TNF HMGB1 22563397 2626272 Positive_regulation TNF HMGB1 22563397 2626273 Positive_regulation TNF HMGB1 22569100 313563 Positive_regulation TNF HMGB1 22778498 1750057 Positive_regulation TNF HMGB1 22869893 1568506 Positive_regulation TNF HMGB1 22869893 1568507 Positive_regulation TNF HMGB1 23209806 2723124 Positive_regulation TNF HMGB1 23209806 2723125 Positive_regulation TNF HMGB1 23209806 2723126 Positive_regulation TNF HMGB1 23209806 2723140 Positive_regulation TNF HMGB1 23209806 2723141 Positive_regulation TNF HMGB1 23209806 2723146 Positive_regulation TNF HMGB1 23209806 2723147 Positive_regulation TNF HMGB1 23209806 2723148 Positive_regulation TNF HMGB1 23209806 2723168 Positive_regulation TNF HMGB1 23209806 2723169 Positive_regulation TNF HMGB1 23209806 2723170 Positive_regulation TNF HMGB1 23209806 2723228 Positive_regulation TNF HMGB1 23209806 2723244 Positive_regulation TNF HMGB1 23209806 2723246 Positive_regulation TNF HMGB1 23209826 2723324 Positive_regulation TNF HMGB1 23617783 268277 Positive_regulation TNF HMGB1 23658798 2790285 Positive_regulation TNF HMGB1 23691208 2794817 Positive_regulation TNF HMGB1 23781123 1753400 Positive_regulation TNF HMGB1 23864765 1754266 Positive_regulation TNF HMGB1 23991365 20552 Positive_regulation TNF HMGB1 24152910 220903 Positive_regulation TNF HMGB1 24152910 220907 Positive_regulation TNF HMGB1 24152910 220913 Positive_regulation TNF HMGB1 24348775 843899 Positive_regulation TNF HMGB1 24708589 314674 Positive_regulation TNF HMGB1 24938416 3082533 Positive_regulation TNF HMGB1 25019241 1943123 Positive_regulation TNF HMGB1 25048472 3233746 Positive_regulation TNF HMGB1 25127031 2998138 Positive_regulation TNF HMGB1 25187820 845002 Positive_regulation TNF HMGB1 25187820 845003 Positive_regulation TNF HMGB1 25477998 827268 Positive_regulation TNF HMGB2 23209826 2723325 Positive_regulation TNF HMGB2 24158500 857058 Positive_regulation TNF HMGB3 23209826 2723326 Positive_regulation TNF HMGB4 23209826 2723323 Positive_regulation TNF HMGN1 22184635 1566800 Positive_regulation TNF HMOX1 23626383 1046740 Positive_regulation TNF HMOX1 23717080 1614009 Positive_regulation TNF HMOX1 24212776 498366 Positive_regulation TNF HMOX1 25255103 3069560 Positive_regulation TNF HNRNPF 11304549 1519272 Positive_regulation TNF HNRNPF 11828008 1522831 Positive_regulation TNF HNRNPF 12437786 1733974 Positive_regulation TNF HNRNPF 15197227 1532947 Positive_regulation TNF HNRNPF 16847068 1541175 Positive_regulation TNF HNRNPF 16847068 1541183 Positive_regulation TNF HNRNPF 18369465 3041035 Positive_regulation TNF HNRNPF 18466643 110689 Positive_regulation TNF HNRNPF 20182538 1746929 Positive_regulation TNF HNRNPF 20574522 2453445 Positive_regulation TNF HNRNPF 21194488 354231 Positive_regulation TNF HNRNPF 21274433 632265 Positive_regulation TNF HNRNPF 21527026 649075 Positive_regulation TNF HNRNPF 22007224 1086037 Positive_regulation TNF HNRNPF 22235359 2371162 Positive_regulation TNF HNRNPF 22363214 3055728 Positive_regulation TNF HNRNPF 22523644 1680583 Positive_regulation TNF HNRNPF 22563430 2626499 Positive_regulation TNF HNRNPF 24039775 2844761 Positive_regulation TNF HNRNPF 24094416 1041417 Positive_regulation TNF HNRNPF 24365457 367447 Positive_regulation TNF HNRNPF 24782985 947737 Positive_regulation TNF HNRNPF 25057505 1622541 Positive_regulation TNF HNRNPF 25071777 913391 Positive_regulation TNF HNRNPF 25111185 2996187 Positive_regulation TNF HNRNPF 7561684 1590650 Positive_regulation TNF HNRNPF 9670049 1603219 Positive_regulation TNF HNRNPH1 11304549 1519273 Positive_regulation TNF HNRNPH1 11828008 1522832 Positive_regulation TNF HNRNPH1 12437786 1733975 Positive_regulation TNF HNRNPH1 15197227 1532948 Positive_regulation TNF HNRNPH1 16847068 1541176 Positive_regulation TNF HNRNPH1 16847068 1541184 Positive_regulation TNF HNRNPH1 18369465 3041036 Positive_regulation TNF HNRNPH1 18466643 110690 Positive_regulation TNF HNRNPH1 20182538 1746930 Positive_regulation TNF HNRNPH1 20574522 2453446 Positive_regulation TNF HNRNPH1 21194488 354232 Positive_regulation TNF HNRNPH1 21274433 632266 Positive_regulation TNF HNRNPH1 21527026 649076 Positive_regulation TNF HNRNPH1 22007224 1086038 Positive_regulation TNF HNRNPH1 22235359 2371163 Positive_regulation TNF HNRNPH1 22363214 3055729 Positive_regulation TNF HNRNPH1 22523644 1680584 Positive_regulation TNF HNRNPH1 22563430 2626500 Positive_regulation TNF HNRNPH1 24039775 2844762 Positive_regulation TNF HNRNPH1 24094416 1041418 Positive_regulation TNF HNRNPH1 24365457 367448 Positive_regulation TNF HNRNPH1 24782985 947738 Positive_regulation TNF HNRNPH1 25057505 1622542 Positive_regulation TNF HNRNPH1 25071777 913392 Positive_regulation TNF HNRNPH1 25111185 2996188 Positive_regulation TNF HNRNPH1 7561684 1590651 Positive_regulation TNF HNRNPH1 9670049 1603220 Positive_regulation TNF HPD 21124909 2484540 Positive_regulation TNF HPD 21124909 2484575 Positive_regulation TNF HPD 22043291 2566057 Positive_regulation TNF HPD 22523581 2620385 Positive_regulation TNF HPD 22523581 2620438 Positive_regulation TNF HPD 24260295 2883668 Positive_regulation TNF HPS1 24852692 3211520 Positive_regulation TNF HRAS 22175014 1686848 Positive_regulation TNF HRAS 22908325 1568733 Positive_regulation TNF HSD17B12 22783260 902467 Positive_regulation TNF HSD17B12 22783260 902482 Positive_regulation TNF HSF1 24167582 2872184 Positive_regulation TNF HSF1 24303143 2251358 Positive_regulation TNF HSF1 25053922 1627969 Positive_regulation TNF HSP90AA1 19715605 283391 Positive_regulation TNF HSP90AA1 23516526 2768250 Positive_regulation TNF HSP90B1 12461080 1525470 Positive_regulation TNF HSPA1A 24213112 499415 Positive_regulation TNF HSPA1A 24213112 499433 Positive_regulation TNF HSPA5 24387801 1162645 Positive_regulation TNF HSPA5 24431899 1636172 Positive_regulation TNF HSPA5 24431899 1636176 Positive_regulation TNF HSPA5 PMC3273066 99510 Positive_regulation TNF HSPB1 10231001 1049486 Positive_regulation TNF HSPB1 18472818 1741825 Positive_regulation TNF HSPB1 23852020 1108381 Positive_regulation TNF HSPB1 24143227 2867926 Positive_regulation TNF HSPB1 24213112 499416 Positive_regulation TNF HSPB1 24213112 499434 Positive_regulation TNF HSPB11 24213112 499411 Positive_regulation TNF HSPB11 24213112 499429 Positive_regulation TNF HSPB2 24213112 499417 Positive_regulation TNF HSPB2 24213112 499435 Positive_regulation TNF HSPB3 16948847 319166 Positive_regulation TNF HSPB3 17996095 321121 Positive_regulation TNF HSPB3 19169254 1948685 Positive_regulation TNF HSPB3 20585575 2453993 Positive_regulation TNF HSPB3 20617138 1215572 Positive_regulation TNF HSPB3 24213112 499418 Positive_regulation TNF HSPB3 24213112 499436 Positive_regulation TNF HSPB3 24971370 1621819 Positive_regulation TNF HSPB3 25344771 349443 Positive_regulation TNF HSPB6 24213112 499412 Positive_regulation TNF HSPB6 24213112 499430 Positive_regulation TNF HSPB7 24213112 499419 Positive_regulation TNF HSPB7 24213112 499437 Positive_regulation TNF HSPB8 23056924 140492 Positive_regulation TNF HSPB8 24213112 499413 Positive_regulation TNF HSPB8 24213112 499431 Positive_regulation TNF HSPB9 24213112 499414 Positive_regulation TNF HSPB9 24213112 499432 Positive_regulation TNF HSPD1 10231012 1049536 Positive_regulation TNF HSPD1 18021431 3108678 Positive_regulation TNF HSPD1 22900050 2674938 Positive_regulation TNF HSPD1 23762847 182060 Positive_regulation TNF HSPD1 23924945 1109757 Positive_regulation TNF HSPD1 23956742 1146919 Positive_regulation TNF HSPD1 25058444 2992087 Positive_regulation TNF HSPD1 25101768 1077099 Positive_regulation TNF HSPD1 25101768 1077101 Positive_regulation TNF HSPG2 14583784 423742 Positive_regulation TNF HSPG2 22942738 1097217 Positive_regulation TNF HSPG2 8760826 1598972 Positive_regulation TNF HSPG2 8760826 1598978 Positive_regulation TNF HTR4 2172437 1564230 Positive_regulation TNF HTR6 2172437 1564231 Positive_regulation TNF HTR7 2172437 1564232 Positive_regulation TNF HTRA1 24883112 1025865 Positive_regulation TNF HTRA1 24979214 2985617 Positive_regulation TNF HTRA2 24883112 1025862 Positive_regulation TNF HTRA3 24883112 1025864 Positive_regulation TNF HTRA4 24883112 1025863 Positive_regulation TNF HUNK 23555760 2775250 Positive_regulation TNF IAPP 11828015 1522853 Positive_regulation TNF IAPP 21935471 2556060 Positive_regulation TNF IARS 23781214 878791 Positive_regulation TNF ICAM1 11132773 1737239 Positive_regulation TNF ICAM1 11817671 1738004 Positive_regulation TNF ICAM1 12438420 1525220 Positive_regulation TNF ICAM1 12581499 1738303 Positive_regulation TNF ICAM1 15144561 648839 Positive_regulation TNF ICAM1 15203563 1739606 Positive_regulation TNF ICAM1 15890069 274366 Positive_regulation TNF ICAM1 16445864 3096172 Positive_regulation TNF ICAM1 16595000 274393 Positive_regulation TNF ICAM1 16595000 274395 Positive_regulation TNF ICAM1 16803639 106170 Positive_regulation TNF ICAM1 17242961 810070 Positive_regulation TNF ICAM1 17383656 1143489 Positive_regulation TNF ICAM1 17498286 274419 Positive_regulation TNF ICAM1 17498286 274420 Positive_regulation TNF ICAM1 17603905 3091143 Positive_regulation TNF ICAM1 18416823 1722700 Positive_regulation TNF ICAM1 18472928 1743244 Positive_regulation TNF ICAM1 19668442 649345 Positive_regulation TNF ICAM1 20386708 2446391 Positive_regulation TNF ICAM1 20652897 774884 Positive_regulation TNF ICAM1 21169918 1734803 Positive_regulation TNF ICAM1 21172007 331844 Positive_regulation TNF ICAM1 21264293 2495220 Positive_regulation TNF ICAM1 21295490 3157822 Positive_regulation TNF ICAM1 21808585 1682052 Positive_regulation TNF ICAM1 22529568 1675246 Positive_regulation TNF ICAM1 22547990 3152614 Positive_regulation TNF ICAM1 23049757 2699420 Positive_regulation TNF ICAM1 23091349 1225106 Positive_regulation TNF ICAM1 23130331 135993 Positive_regulation TNF ICAM1 23284977 2731372 Positive_regulation TNF ICAM1 23285008 2731528 Positive_regulation TNF ICAM1 23527096 2769363 Positive_regulation TNF ICAM1 23592916 1915849 Positive_regulation TNF ICAM1 23592916 1915850 Positive_regulation TNF ICAM1 23671702 2792483 Positive_regulation TNF ICAM1 23690670 1752081 Positive_regulation TNF ICAM1 23878502 1916067 Positive_regulation TNF ICAM1 23895132 1726239 Positive_regulation TNF ICAM1 23929007 87354 Positive_regulation TNF ICAM1 23972823 1666976 Positive_regulation TNF ICAM1 24069252 2852291 Positive_regulation TNF ICAM1 24106604 1764610 Positive_regulation TNF ICAM1 24116032 2864990 Positive_regulation TNF ICAM1 24237643 1728468 Positive_regulation TNF ICAM1 24312346 2888816 Positive_regulation TNF ICAM1 24371374 1755974 Positive_regulation TNF ICAM1 24490631 131691 Positive_regulation TNF ICAM1 24502696 1233145 Positive_regulation TNF ICAM1 24516598 2921160 Positive_regulation TNF ICAM1 24603712 2931974 Positive_regulation TNF ICAM1 24887557 2975924 Positive_regulation TNF ICAM1 24940033 1917042 Positive_regulation TNF ICAM1 24940033 1917043 Positive_regulation TNF ICAM1 24940033 1917044 Positive_regulation TNF ICAM1 24940033 1917076 Positive_regulation TNF ICAM1 24940033 1917078 Positive_regulation TNF ICAM1 25025040 194660 Positive_regulation TNF ICAM1 25032222 194875 Positive_regulation TNF ICAM1 25061328 645469 Positive_regulation TNF ICAM1 25529562 1736731 Positive_regulation TNF ICAM1 7705312 796397 Positive_regulation TNF ICAM2 21172007 331845 Positive_regulation TNF ICAM2 23091349 1225107 Positive_regulation TNF ICAM2 24371374 1755975 Positive_regulation TNF ICAM2 24940033 1917045 Positive_regulation TNF ICAM2 25061328 645470 Positive_regulation TNF ICAM3 21172007 331846 Positive_regulation TNF ICAM3 23091349 1225108 Positive_regulation TNF ICAM3 24371374 1755976 Positive_regulation TNF ICAM3 24940033 1917046 Positive_regulation TNF ICAM3 25061328 645471 Positive_regulation TNF ICAM4 21172007 331847 Positive_regulation TNF ICAM4 23091349 1225109 Positive_regulation TNF ICAM4 24371374 1755977 Positive_regulation TNF ICAM4 24940033 1917047 Positive_regulation TNF ICAM4 25061328 645472 Positive_regulation TNF ICAM5 21172007 331848 Positive_regulation TNF ICAM5 23091349 1225110 Positive_regulation TNF ICAM5 24371374 1755978 Positive_regulation TNF ICAM5 24940033 1917048 Positive_regulation TNF ICAM5 25061328 645473 Positive_regulation TNF ICOS 12538664 1525767 Positive_regulation TNF ICOSLG 22567028 634386 Positive_regulation TNF ICR1 6386027 443703 Positive_regulation TNF ICR3 6386027 443704 Positive_regulation TNF ICR4 6386027 443705 Positive_regulation TNF ICR5 6386027 443706 Positive_regulation TNF ID1 20010941 434209 Positive_regulation TNF ID1 20010941 434210 Positive_regulation TNF ID1 20010941 434215 Positive_regulation TNF ID1 20010941 434220 Positive_regulation TNF ID1 20010941 434221 Positive_regulation TNF ID1 20010941 434222 Positive_regulation TNF ID1 20010941 434225 Positive_regulation TNF ID1 20010941 434229 Positive_regulation TNF ID1 20010941 434230 Positive_regulation TNF ID1 20010941 434233 Positive_regulation TNF IDO1 18466643 110691 Positive_regulation TNF IDO1 21810259 1659106 Positive_regulation TNF IDO1 22083605 600437 Positive_regulation TNF IDO1 25003339 2986961 Positive_regulation TNF IFI44 11781369 1522160 Positive_regulation TNF IFI44 16581537 792559 Positive_regulation TNF IFI44 23209344 1750767 Positive_regulation TNF IFIH1 18617992 3041649 Positive_regulation TNF IFIT1 23626859 2785153 Positive_regulation TNF IFIT2 19108715 352537 Positive_regulation TNF IFIT2 22808421 3130952 Positive_regulation TNF IFIT2 23626859 2785154 Positive_regulation TNF IFIT3 22322095 1882589 Positive_regulation TNF IFIT5 22203836 832436 Positive_regulation TNF IFIT5 7519620 1436158 Positive_regulation TNF IFITM2 17822540 395880 Positive_regulation TNF IFN1@ 22567325 1680753 Positive_regulation TNF IFN1@ 24751903 2956152 Positive_regulation TNF IFNB1 20361029 2370710 Positive_regulation TNF IFNB1 20361029 2370714 Positive_regulation TNF IFNB1 20361029 2370715 Positive_regulation TNF IFNG 18474096 110747 Positive_regulation TNF IFNG 18475620 1744848 Positive_regulation TNF IFNG 18553155 3090049 Positive_regulation TNF IFNG 20174649 2441593 Positive_regulation TNF IFNG 20174649 2441595 Positive_regulation TNF IFNG 20361029 2370708 Positive_regulation TNF IFNG 20361029 2370718 Positive_regulation TNF IFNG 20361029 2370720 Positive_regulation TNF IFNG 20361029 2370722 Positive_regulation TNF IFNG 21666746 2527880 Positive_regulation TNF IFNG 22359543 2597621 Positive_regulation TNF IFNG 23013558 395941 Positive_regulation TNF IFNG 2407799 1573717 Positive_regulation TNF IFNG 24791137 1916881 Positive_regulation TNF IFNG 2521357 1577191 Positive_regulation TNF IFNG 2803915 442967 Positive_regulation TNF IFNL1 23974516 18470 Positive_regulation TNF IFNL1 24286242 130909 Positive_regulation TNF IFNL1 PMC4126180 787247 Positive_regulation TNF IFNR 1901078 1552804 Positive_regulation TNF IGF1 18513402 110834 Positive_regulation TNF IGF1 18513402 110835 Positive_regulation TNF IGF1 21371294 1657809 Positive_regulation TNF IGF1 21371294 1657810 Positive_regulation TNF IGF1 21371294 1657811 Positive_regulation TNF IGF1 21371294 1657915 Positive_regulation TNF IGF1 22235273 2585723 Positive_regulation TNF IGF1R 21371294 1657812 Positive_regulation TNF IGF2 18513402 110836 Positive_regulation TNF IGF2 18513402 110837 Positive_regulation TNF IGF2 22235273 2585724 Positive_regulation TNF IGKV1-27 21242294 1562402 Positive_regulation TNF IGKV1-27 22979947 406939 Positive_regulation TNF IGKV1-27 24479486 1667589 Positive_regulation TNF IGKV1-27 24917867 913070 Positive_regulation TNF IGKV1-27 24971461 2984421 Positive_regulation TNF IGKV3-20 24428943 1701210 Positive_regulation TNF IKBKB 16177180 2017707 Positive_regulation TNF IKBKB 19640296 325842 Positive_regulation TNF IKBKB 20221401 2442502 Positive_regulation TNF IKBKB 21119000 1783908 Positive_regulation TNF IKBKB 21119000 1783943 Positive_regulation TNF IKBKB 21298084 2320964 Positive_regulation TNF IKBKB 21298084 2320965 Positive_regulation TNF IKBKB 21298084 2320972 Positive_regulation TNF IKBKB 21342546 238028 Positive_regulation TNF IKBKB 22701747 2652529 Positive_regulation TNF IKBKB 22704338 640104 Positive_regulation TNF IKBKB 22848449 2669103 Positive_regulation TNF IKBKB 23144925 2714926 Positive_regulation TNF IKBKB 24213137 499566 Positive_regulation TNF IKBKB 24911653 152851 Positive_regulation TNF IKBKB 25762184 1623424 Positive_regulation TNF IKBKB 25762184 1623431 Positive_regulation TNF IKBKB 9841930 1604791 Positive_regulation TNF IKBKG 20221401 2442503 Positive_regulation TNF IKBKG 21119000 1783909 Positive_regulation TNF IKBKG 21119000 1783944 Positive_regulation TNF IKBKG 21298084 2320966 Positive_regulation TNF IKBKG 21298084 2320967 Positive_regulation TNF IKBKG 21298084 2320973 Positive_regulation TNF IKBKG 21342546 238029 Positive_regulation TNF IKBKG 22701747 2652530 Positive_regulation TNF IKBKG 22704338 640105 Positive_regulation TNF IKBKG 22848449 2669104 Positive_regulation TNF IKBKG 23144925 2714927 Positive_regulation TNF IKBKG 24446482 1415320 Positive_regulation TNF IKBKG 24911653 152852 Positive_regulation TNF IKBKG 25762184 1623425 Positive_regulation TNF IKBKG 25762184 1623432 Positive_regulation TNF IKBKG 9841930 1604792 Positive_regulation TNF IL10 11056670 97958 Positive_regulation TNF IL10 11850581 1632876 Positive_regulation TNF IL10 12061423 1738137 Positive_regulation TNF IL10 12417634 1525209 Positive_regulation TNF IL10 12575899 1843402 Positive_regulation TNF IL10 12782719 1527579 Positive_regulation TNF IL10 14651752 3095638 Positive_regulation TNF IL10 1586593 426022 Positive_regulation TNF IL10 1643416 702447 Positive_regulation TNF IL10 16859503 106257 Positive_regulation TNF IL10 16859503 106263 Positive_regulation TNF IL10 16859503 106275 Positive_regulation TNF IL10 1692079 1542158 Positive_regulation TNF IL10 1717633 1543690 Positive_regulation TNF IL10 17392587 1741407 Positive_regulation TNF IL10 17392587 1741411 Positive_regulation TNF IL10 18179717 991658 Positive_regulation TNF IL10 18475440 1743742 Positive_regulation TNF IL10 1911209 431544 Positive_regulation TNF IL10 19451266 1554826 Positive_regulation TNF IL10 19454012 659236 Positive_regulation TNF IL10 19701461 2424382 Positive_regulation TNF IL10 19720840 1556138 Positive_regulation TNF IL10 19771178 2214656 Positive_regulation TNF IL10 19901996 1746766 Positive_regulation TNF IL10 20051129 3110164 Positive_regulation TNF IL10 2007858 1557271 Positive_regulation TNF IL10 2022925 1557551 Positive_regulation TNF IL10 2039696 434733 Positive_regulation TNF IL10 20544034 2452620 Positive_regulation TNF IL10 21170379 2487260 Positive_regulation TNF IL10 21245929 2492848 Positive_regulation TNF IL10 21267358 742429 Positive_regulation TNF IL10 21269456 3213914 Positive_regulation TNF IL10 21314968 3209857 Positive_regulation TNF IL10 21801431 123352 Positive_regulation TNF IL10 21829352 3052596 Positive_regulation TNF IL10 2183871 437478 Positive_regulation TNF IL10 2183871 437535 Positive_regulation TNF IL10 21884646 659984 Positive_regulation TNF IL10 21949832 2556784 Positive_regulation TNF IL10 22095690 1033504 Positive_regulation TNF IL10 22194991 2583715 Positive_regulation TNF IL10 22272381 1082509 Positive_regulation TNF IL10 22359634 2598639 Positive_regulation TNF IL10 22457616 3055875 Positive_regulation TNF IL10 22518279 1079955 Positive_regulation TNF IL10 22530124 2009501 Positive_regulation TNF IL10 22545014 3152562 Positive_regulation TNF IL10 22570532 1224113 Positive_regulation TNF IL10 2258696 1568167 Positive_regulation TNF IL10 22646809 1728182 Positive_regulation TNF IL10 22879986 2673390 Positive_regulation TNF IL10 22916219 2680211 Positive_regulation TNF IL10 23029434 2697376 Positive_regulation TNF IL10 23082146 2705288 Positive_regulation TNF IL10 23168705 1045226 Positive_regulation TNF IL10 23227067 3204539 Positive_regulation TNF IL10 23282404 3225262 Positive_regulation TNF IL10 23316193 905648 Positive_regulation TNF IL10 23555865 2775699 Positive_regulation TNF IL10 23606988 2003095 Positive_regulation TNF IL10 23690660 1751925 Positive_regulation TNF IL10 23691272 1703087 Positive_regulation TNF IL10 2373990 1572242 Positive_regulation TNF IL10 23800014 1232207 Positive_regulation TNF IL10 23844248 2819623 Positive_regulation TNF IL10 23857174 2117615 Positive_regulation TNF IL10 23869227 2821179 Positive_regulation TNF IL10 23908975 649290 Positive_regulation TNF IL10 23956501 1754445 Positive_regulation TNF IL10 24058765 1705135 Positive_regulation TNF IL10 2406363 1573673 Positive_regulation TNF IL10 24069337 2852807 Positive_regulation TNF IL10 24069500 2372106 Positive_regulation TNF IL10 24130911 2372249 Positive_regulation TNF IL10 24187561 638998 Positive_regulation TNF IL10 24212943 499208 Positive_regulation TNF IL10 24252176 5772 Positive_regulation TNF IL10 24382974 639483 Positive_regulation TNF IL10 24434259 1045745 Positive_regulation TNF IL10 24456582 1701256 Positive_regulation TNF IL10 24722226 3066652 Positive_regulation TNF IL10 24804272 1621485 Positive_regulation TNF IL10 24911280 2977599 Positive_regulation TNF IL10 2499653 1576962 Positive_regulation TNF IL10 25085377 88954 Positive_regulation TNF IL10 25187652 1621063 Positive_regulation TNF IL10 25329163 3015913 Positive_regulation TNF IL10 25339958 914728 Positive_regulation TNF IL10 25479410 3032266 Positive_regulation TNF IL10 25566439 1498413 Positive_regulation TNF IL10 25629008 865420 Positive_regulation TNF IL10 2642531 1577539 Positive_regulation TNF IL10 2659724 1577628 Positive_regulation TNF IL10 2769183 1577853 Positive_regulation TNF IL10 2785398 442895 Positive_regulation TNF IL10 2833558 1578507 Positive_regulation TNF IL10 3049617 1425433 Positive_regulation TNF IL10 3049617 1425524 Positive_regulation TNF IL10 3049617 1425525 Positive_regulation TNF IL10 3110354 1580026 Positive_regulation TNF IL10 3137305 1580339 Positive_regulation TNF IL10 3143799 1580394 Positive_regulation TNF IL10 3290384 1580760 Positive_regulation TNF IL10 3309124 1580878 Positive_regulation TNF IL10 3309124 1580933 Positive_regulation TNF IL10 3316469 1580993 Positive_regulation TNF IL10 3411293 1581159 Positive_regulation TNF IL10 3435706 443474 Positive_regulation TNF IL10 3491174 1583064 Positive_regulation TNF IL10 3494807 1583201 Positive_regulation TNF IL10 3494807 1583202 Positive_regulation TNF IL10 3494807 1583303 Positive_regulation TNF IL10 3572302 1583442 Positive_regulation TNF IL10 3598461 1583500 Positive_regulation TNF IL10 3819645 1583677 Positive_regulation TNF IL10 7722463 1592058 Positive_regulation TNF IL10 8260432 1030844 Positive_regulation TNF IL10 8270873 1594775 Positive_regulation TNF IL10 8426121 1595169 Positive_regulation TNF IL10 8478614 1595519 Positive_regulation TNF IL10 9151895 1601144 Positive_regulation TNF IL10 PMC2188223 1605368 Positive_regulation TNF IL10 PMC4068323 661184 Positive_regulation TNF IL10RA 23569462 1240028 Positive_regulation TNF IL10RB 23569462 1240029 Positive_regulation TNF IL11 1586593 426023 Positive_regulation TNF IL11 1643416 702448 Positive_regulation TNF IL11 1692079 1542159 Positive_regulation TNF IL11 1717633 1543691 Positive_regulation TNF IL11 18475440 1743743 Positive_regulation TNF IL11 1911209 431545 Positive_regulation TNF IL11 19901996 1746767 Positive_regulation TNF IL11 2007858 1557272 Positive_regulation TNF IL11 2022925 1557552 Positive_regulation TNF IL11 2039696 434734 Positive_regulation TNF IL11 21267358 742430 Positive_regulation TNF IL11 21801431 123353 Positive_regulation TNF IL11 21829352 3052597 Positive_regulation TNF IL11 2183871 437479 Positive_regulation TNF IL11 2183871 437536 Positive_regulation TNF IL11 22570532 1224114 Positive_regulation TNF IL11 2258696 1568168 Positive_regulation TNF IL11 2373990 1572243 Positive_regulation TNF IL11 2406363 1573674 Positive_regulation TNF IL11 2499653 1576963 Positive_regulation TNF IL11 2642531 1577540 Positive_regulation TNF IL11 2659724 1577629 Positive_regulation TNF IL11 2769183 1577854 Positive_regulation TNF IL11 2785398 442896 Positive_regulation TNF IL11 2833558 1578508 Positive_regulation TNF IL11 3049617 1425434 Positive_regulation TNF IL11 3049617 1425526 Positive_regulation TNF IL11 3049617 1425527 Positive_regulation TNF IL11 3110354 1580027 Positive_regulation TNF IL11 3137305 1580340 Positive_regulation TNF IL11 3143799 1580395 Positive_regulation TNF IL11 3290384 1580761 Positive_regulation TNF IL11 3309124 1580879 Positive_regulation TNF IL11 3309124 1580934 Positive_regulation TNF IL11 3316469 1580994 Positive_regulation TNF IL11 3411293 1581160 Positive_regulation TNF IL11 3435706 443475 Positive_regulation TNF IL11 3491174 1583065 Positive_regulation TNF IL11 3494807 1583203 Positive_regulation TNF IL11 3494807 1583204 Positive_regulation TNF IL11 3494807 1583304 Positive_regulation TNF IL11 3572302 1583443 Positive_regulation TNF IL11 3598461 1583501 Positive_regulation TNF IL11 3819645 1583678 Positive_regulation TNF IL11 8260432 1030845 Positive_regulation TNF IL11 8426121 1595170 Positive_regulation TNF IL11 8478614 1595520 Positive_regulation TNF IL11 PMC2188223 1605369 Positive_regulation TNF IL12A 10880525 1516049 Positive_regulation TNF IL12A 11178126 98332 Positive_regulation TNF IL12A 15813981 1624713 Positive_regulation TNF IL12A 16258194 1740188 Positive_regulation TNF IL12A 17923504 1547247 Positive_regulation TNF IL12A 18076766 1695774 Positive_regulation TNF IL12A 18990205 1670769 Positive_regulation TNF IL12A 19112508 2402830 Positive_regulation TNF IL12A 19478959 631832 Positive_regulation TNF IL12A 19582164 2420991 Positive_regulation TNF IL12A 20051129 3110165 Positive_regulation TNF IL12A 20169058 2370640 Positive_regulation TNF IL12A 20831789 366062 Positive_regulation TNF IL12A 20875106 330163 Positive_regulation TNF IL12A 21298114 2499881 Positive_regulation TNF IL12A 21591259 776232 Positive_regulation TNF IL12A 21738161 1961554 Positive_regulation TNF IL12A 21829352 3052598 Positive_regulation TNF IL12A 22110393 1058627 Positive_regulation TNF IL12A 22438968 2612428 Positive_regulation TNF IL12A 22438968 2612434 Positive_regulation TNF IL12A 22506098 1680487 Positive_regulation TNF IL12A 22566877 899138 Positive_regulation TNF IL12A 22624013 2644752 Positive_regulation TNF IL12A 22675381 814572 Positive_regulation TNF IL12A 22977683 2115206 Positive_regulation TNF IL12A 23144752 2714394 Positive_regulation TNF IL12A 23202920 1098602 Positive_regulation TNF IL12A 23301222 89165 Positive_regulation TNF IL12A 23533314 1751870 Positive_regulation TNF IL12A 23634300 3204460 Positive_regulation TNF IL12A 23641151 2234815 Positive_regulation TNF IL12A 23696707 2121324 Positive_regulation TNF IL12A 23762085 637543 Positive_regulation TNF IL12A 23762085 637571 Positive_regulation TNF IL12A 23844018 2819014 Positive_regulation TNF IL12A 23945602 1729988 Positive_regulation TNF IL12A 23951210 2833715 Positive_regulation TNF IL12A 23959031 3217817 Positive_regulation TNF IL12A 23980098 1573541 Positive_regulation TNF IL12A 24015193 2842197 Positive_regulation TNF IL12A 24130485 3064391 Positive_regulation TNF IL12A 24273539 909913 Positive_regulation TNF IL12A 24365457 367470 Positive_regulation TNF IL12A 24406319 840208 Positive_regulation TNF IL12A 24475289 2915443 Positive_regulation TNF IL12A 24568275 357522 Positive_regulation TNF IL12A 24586980 2928544 Positive_regulation TNF IL12A 24637903 2934971 Positive_regulation TNF IL12A 24683394 3070927 Positive_regulation TNF IL12A 24982658 913161 Positive_regulation TNF IL12A 25061260 1760232 Positive_regulation TNF IL12A 25371910 1623346 Positive_regulation TNF IL12A 25552899 744120 Positive_regulation TNF IL12A 7516408 1589253 Positive_regulation TNF IL12A 7561678 1590548 Positive_regulation TNF IL12A 7722464 1592059 Positive_regulation TNF IL12A 7869050 1592799 Positive_regulation TNF IL12A 7869050 1592803 Positive_regulation TNF IL12A 8102388 1594059 Positive_regulation TNF IL12A 8104230 1594101 Positive_regulation TNF IL12A 9104810 1600615 Positive_regulation TNF IL12A 9104810 1600616 Positive_regulation TNF IL12A 9382881 1602101 Positive_regulation TNF IL12B 10880525 1516050 Positive_regulation TNF IL12B 11178126 98333 Positive_regulation TNF IL12B 15813981 1624714 Positive_regulation TNF IL12B 16258194 1740189 Positive_regulation TNF IL12B 17306038 107816 Positive_regulation TNF IL12B 17923504 1547248 Positive_regulation TNF IL12B 18990205 1670770 Positive_regulation TNF IL12B 19112508 2402831 Positive_regulation TNF IL12B 19478959 631833 Positive_regulation TNF IL12B 19582164 2420992 Positive_regulation TNF IL12B 19815670 3126153 Positive_regulation TNF IL12B 20051129 3110166 Positive_regulation TNF IL12B 20169058 2370641 Positive_regulation TNF IL12B 20831789 366063 Positive_regulation TNF IL12B 20875106 330164 Positive_regulation TNF IL12B 21298114 2499882 Positive_regulation TNF IL12B 21591259 776233 Positive_regulation TNF IL12B 21738161 1961555 Positive_regulation TNF IL12B 21829352 3052599 Positive_regulation TNF IL12B 22110393 1058628 Positive_regulation TNF IL12B 22269588 1660769 Positive_regulation TNF IL12B 22417709 125167 Positive_regulation TNF IL12B 22506098 1680488 Positive_regulation TNF IL12B 22566877 899139 Positive_regulation TNF IL12B 22624013 2644753 Positive_regulation TNF IL12B 22675381 814573 Positive_regulation TNF IL12B 22977683 2115207 Positive_regulation TNF IL12B 23144752 2714395 Positive_regulation TNF IL12B 23202920 1098603 Positive_regulation TNF IL12B 23301222 89166 Positive_regulation TNF IL12B 23301223 89168 Positive_regulation TNF IL12B 23316190 905571 Positive_regulation TNF IL12B 23319986 95353 Positive_regulation TNF IL12B 23533314 1751871 Positive_regulation TNF IL12B 23634300 3204461 Positive_regulation TNF IL12B 23641151 2234816 Positive_regulation TNF IL12B 23696707 2121325 Positive_regulation TNF IL12B 23762085 637544 Positive_regulation TNF IL12B 23762085 637572 Positive_regulation TNF IL12B 23844018 2819015 Positive_regulation TNF IL12B 23945602 1729989 Positive_regulation TNF IL12B 23951210 2833716 Positive_regulation TNF IL12B 23959031 3217818 Positive_regulation TNF IL12B 23980098 1573542 Positive_regulation TNF IL12B 24015193 2842198 Positive_regulation TNF IL12B 24023721 2843394 Positive_regulation TNF IL12B 24130485 3064392 Positive_regulation TNF IL12B 24273539 909914 Positive_regulation TNF IL12B 24365457 367471 Positive_regulation TNF IL12B 24406319 840209 Positive_regulation TNF IL12B 24475289 2915444 Positive_regulation TNF IL12B 24568275 357523 Positive_regulation TNF IL12B 24586980 2928545 Positive_regulation TNF IL12B 24637903 2934972 Positive_regulation TNF IL12B 24683394 3070928 Positive_regulation TNF IL12B 24982658 913162 Positive_regulation TNF IL12B 25015728 2195839 Positive_regulation TNF IL12B 25061260 1760233 Positive_regulation TNF IL12B 25061260 1760234 Positive_regulation TNF IL12B 25105894 2996095 Positive_regulation TNF IL12B 25371910 1623347 Positive_regulation TNF IL12B 25552899 744121 Positive_regulation TNF IL12B 7516408 1589254 Positive_regulation TNF IL12B 7561678 1590549 Positive_regulation TNF IL12B 7722464 1592060 Positive_regulation TNF IL12B 7869050 1592800 Positive_regulation TNF IL12B 7869050 1592804 Positive_regulation TNF IL12B 8102388 1594060 Positive_regulation TNF IL12B 8104230 1594102 Positive_regulation TNF IL12B 9104810 1600617 Positive_regulation TNF IL12B 9104810 1600618 Positive_regulation TNF IL12B 9382881 1602102 Positive_regulation TNF IL13 1586593 426024 Positive_regulation TNF IL13 1643416 702449 Positive_regulation TNF IL13 1692079 1542160 Positive_regulation TNF IL13 1717633 1543692 Positive_regulation TNF IL13 17392576 1741310 Positive_regulation TNF IL13 18475440 1743744 Positive_regulation TNF IL13 1911209 431546 Positive_regulation TNF IL13 19901996 1746768 Positive_regulation TNF IL13 2007858 1557273 Positive_regulation TNF IL13 2022925 1557553 Positive_regulation TNF IL13 2039696 434735 Positive_regulation TNF IL13 21267358 742431 Positive_regulation TNF IL13 21801431 123354 Positive_regulation TNF IL13 21829352 3052600 Positive_regulation TNF IL13 2183871 437480 Positive_regulation TNF IL13 2183871 437537 Positive_regulation TNF IL13 22570532 1224115 Positive_regulation TNF IL13 2258696 1568169 Positive_regulation TNF IL13 2373990 1572244 Positive_regulation TNF IL13 2406363 1573675 Positive_regulation TNF IL13 24286242 130910 Positive_regulation TNF IL13 2499653 1576964 Positive_regulation TNF IL13 25398130 3027516 Positive_regulation TNF IL13 2642531 1577541 Positive_regulation TNF IL13 2659724 1577630 Positive_regulation TNF IL13 2769183 1577855 Positive_regulation TNF IL13 2785398 442897 Positive_regulation TNF IL13 2833558 1578509 Positive_regulation TNF IL13 3049617 1425435 Positive_regulation TNF IL13 3049617 1425528 Positive_regulation TNF IL13 3049617 1425529 Positive_regulation TNF IL13 3110354 1580028 Positive_regulation TNF IL13 3137305 1580341 Positive_regulation TNF IL13 3143799 1580396 Positive_regulation TNF IL13 3290384 1580762 Positive_regulation TNF IL13 3309124 1580880 Positive_regulation TNF IL13 3309124 1580935 Positive_regulation TNF IL13 3316469 1580995 Positive_regulation TNF IL13 3411293 1581161 Positive_regulation TNF IL13 3435706 443476 Positive_regulation TNF IL13 3491174 1583066 Positive_regulation TNF IL13 3494807 1583205 Positive_regulation TNF IL13 3494807 1583206 Positive_regulation TNF IL13 3494807 1583305 Positive_regulation TNF IL13 3572302 1583444 Positive_regulation TNF IL13 3598461 1583502 Positive_regulation TNF IL13 3819645 1583679 Positive_regulation TNF IL13 8260432 1030846 Positive_regulation TNF IL13 8426121 1595171 Positive_regulation TNF IL13 8478614 1595521 Positive_regulation TNF IL13 PMC2188223 1605370 Positive_regulation TNF IL15 10429666 1512041 Positive_regulation TNF IL15 10429666 1512047 Positive_regulation TNF IL15 11219394 98358 Positive_regulation TNF IL15 15225362 101355 Positive_regulation TNF IL15 15686595 3115415 Positive_regulation TNF IL15 1586593 426025 Positive_regulation TNF IL15 1643416 702450 Positive_regulation TNF IL15 16684368 105994 Positive_regulation TNF IL15 1692079 1542161 Positive_regulation TNF IL15 1717633 1543693 Positive_regulation TNF IL15 18475440 1743745 Positive_regulation TNF IL15 18957484 90866 Positive_regulation TNF IL15 1911209 431547 Positive_regulation TNF IL15 19901996 1746769 Positive_regulation TNF IL15 19934004 711852 Positive_regulation TNF IL15 19934004 711863 Positive_regulation TNF IL15 2007858 1557274 Positive_regulation TNF IL15 2022925 1557554 Positive_regulation TNF IL15 2039696 434736 Positive_regulation TNF IL15 21267358 742432 Positive_regulation TNF IL15 21716670 1222202 Positive_regulation TNF IL15 21801431 123355 Positive_regulation TNF IL15 21829352 3052601 Positive_regulation TNF IL15 2183871 437481 Positive_regulation TNF IL15 2183871 437538 Positive_regulation TNF IL15 22547986 3152578 Positive_regulation TNF IL15 22570532 1224116 Positive_regulation TNF IL15 2258696 1568170 Positive_regulation TNF IL15 22888423 97654 Positive_regulation TNF IL15 23049531 904426 Positive_regulation TNF IL15 23319993 3204615 Positive_regulation TNF IL15 2373990 1572245 Positive_regulation TNF IL15 23950892 2832721 Positive_regulation TNF IL15 2406363 1573676 Positive_regulation TNF IL15 24167367 737408 Positive_regulation TNF IL15 24391825 2904647 Positive_regulation TNF IL15 2499653 1576965 Positive_regulation TNF IL15 25548436 1763508 Positive_regulation TNF IL15 2642531 1577542 Positive_regulation TNF IL15 2659724 1577631 Positive_regulation TNF IL15 2769183 1577856 Positive_regulation TNF IL15 2785398 442898 Positive_regulation TNF IL15 2833558 1578510 Positive_regulation TNF IL15 3049617 1425436 Positive_regulation TNF IL15 3049617 1425530 Positive_regulation TNF IL15 3049617 1425531 Positive_regulation TNF IL15 3110354 1580029 Positive_regulation TNF IL15 3137305 1580342 Positive_regulation TNF IL15 3143799 1580397 Positive_regulation TNF IL15 3290384 1580763 Positive_regulation TNF IL15 3309124 1580881 Positive_regulation TNF IL15 3309124 1580936 Positive_regulation TNF IL15 3316469 1580996 Positive_regulation TNF IL15 3411293 1581162 Positive_regulation TNF IL15 3435706 443477 Positive_regulation TNF IL15 3491174 1583067 Positive_regulation TNF IL15 3494807 1583207 Positive_regulation TNF IL15 3494807 1583208 Positive_regulation TNF IL15 3494807 1583306 Positive_regulation TNF IL15 3572302 1583445 Positive_regulation TNF IL15 3598461 1583503 Positive_regulation TNF IL15 3819645 1583680 Positive_regulation TNF IL15 8260432 1030847 Positive_regulation TNF IL15 8426121 1595172 Positive_regulation TNF IL15 8478614 1595522 Positive_regulation TNF IL15 8478614 1595563 Positive_regulation TNF IL15 PMC2188223 1605371 Positive_regulation TNF IL15 PMC2833833 134352 Positive_regulation TNF IL15 PMC2834061 134538 Positive_regulation TNF IL16 1586593 426026 Positive_regulation TNF IL16 1643416 702451 Positive_regulation TNF IL16 1692079 1542162 Positive_regulation TNF IL16 1717633 1543694 Positive_regulation TNF IL16 17221335 94963 Positive_regulation TNF IL16 18475440 1743746 Positive_regulation TNF IL16 1911209 431548 Positive_regulation TNF IL16 19901996 1746770 Positive_regulation TNF IL16 2007858 1557275 Positive_regulation TNF IL16 2022925 1557555 Positive_regulation TNF IL16 2039696 434737 Positive_regulation TNF IL16 20509936 143299 Positive_regulation TNF IL16 21267358 742433 Positive_regulation TNF IL16 21801431 123356 Positive_regulation TNF IL16 21829352 3052602 Positive_regulation TNF IL16 2183871 437482 Positive_regulation TNF IL16 2183871 437539 Positive_regulation TNF IL16 22570532 1224117 Positive_regulation TNF IL16 2258696 1568171 Positive_regulation TNF IL16 2373990 1572246 Positive_regulation TNF IL16 2406363 1573677 Positive_regulation TNF IL16 2499653 1576966 Positive_regulation TNF IL16 2642531 1577543 Positive_regulation TNF IL16 2659724 1577632 Positive_regulation TNF IL16 2769183 1577857 Positive_regulation TNF IL16 2785398 442899 Positive_regulation TNF IL16 2833558 1578511 Positive_regulation TNF IL16 3049617 1425437 Positive_regulation TNF IL16 3049617 1425532 Positive_regulation TNF IL16 3049617 1425533 Positive_regulation TNF IL16 3110354 1580030 Positive_regulation TNF IL16 3137305 1580343 Positive_regulation TNF IL16 3143799 1580398 Positive_regulation TNF IL16 3290384 1580764 Positive_regulation TNF IL16 3309124 1580882 Positive_regulation TNF IL16 3309124 1580937 Positive_regulation TNF IL16 3316469 1580997 Positive_regulation TNF IL16 3411293 1581163 Positive_regulation TNF IL16 3435706 443478 Positive_regulation TNF IL16 3491174 1583068 Positive_regulation TNF IL16 3494807 1583209 Positive_regulation TNF IL16 3494807 1583210 Positive_regulation TNF IL16 3494807 1583307 Positive_regulation TNF IL16 3572302 1583446 Positive_regulation TNF IL16 3598461 1583504 Positive_regulation TNF IL16 3819645 1583681 Positive_regulation TNF IL16 8260432 1030848 Positive_regulation TNF IL16 8426121 1595173 Positive_regulation TNF IL16 8478614 1595523 Positive_regulation TNF IL16 PMC2188223 1605372 Positive_regulation TNF IL17A 11299057 98390 Positive_regulation TNF IL17A 11299057 98394 Positive_regulation TNF IL17A 12223101 99343 Positive_regulation TNF IL17A 17306038 107836 Positive_regulation TNF IL17A 19007422 111933 Positive_regulation TNF IL17A 19014637 463263 Positive_regulation TNF IL17A 19400960 1655734 Positive_regulation TNF IL17A 19519923 113490 Positive_regulation TNF IL17A 19627579 116154 Positive_regulation TNF IL17A 19759900 2426560 Positive_regulation TNF IL17A 20101303 1043907 Positive_regulation TNF IL17A 20169058 2370629 Positive_regulation TNF IL17A 20169058 2370634 Positive_regulation TNF IL17A 20374638 328795 Positive_regulation TNF IL17A 20544034 2452621 Positive_regulation TNF IL17A 21235788 3213849 Positive_regulation TNF IL17A 21294864 121384 Positive_regulation TNF IL17A 21294864 121396 Positive_regulation TNF IL17A 21294864 121408 Positive_regulation TNF IL17A 21294864 121414 Positive_regulation TNF IL17A 21294864 121433 Positive_regulation TNF IL17A 22028860 2564568 Positive_regulation TNF IL17A 22030025 1065698 Positive_regulation TNF IL17A 22083605 600418 Positive_regulation TNF IL17A 22363157 88179 Positive_regulation TNF IL17A 22724038 2371417 Positive_regulation TNF IL17A 22724038 2371419 Positive_regulation TNF IL17A 22754280 1224411 Positive_regulation TNF IL17A 22855687 902728 Positive_regulation TNF IL17A 22855687 902729 Positive_regulation TNF IL17A 22970248 2687832 Positive_regulation TNF IL17A 22970248 2687834 Positive_regulation TNF IL17A 23028407 2219736 Positive_regulation TNF IL17A 23116200 127071 Positive_regulation TNF IL17A 23197904 88221 Positive_regulation TNF IL17A 23301223 89173 Positive_regulation TNF IL17A 23372655 2745629 Positive_regulation TNF IL17A 23403648 843012 Positive_regulation TNF IL17A 23515267 629878 Positive_regulation TNF IL17A 23691272 1703089 Positive_regulation TNF IL17A 23819611 2231761 Positive_regulation TNF IL17A 23870279 294552 Positive_regulation TNF IL17A 23977238 2839382 Positive_regulation TNF IL17A 23977238 2839396 Positive_regulation TNF IL17A 23984335 183313 Positive_regulation TNF IL17A 23994464 1051375 Positive_regulation TNF IL17A 24084730 1113167 Positive_regulation TNF IL17A 24148767 220845 Positive_regulation TNF IL17A 24148767 220850 Positive_regulation TNF IL17A 24221190 3126131 Positive_regulation TNF IL17A 24302815 1755338 Positive_regulation TNF IL17A 24358317 2899533 Positive_regulation TNF IL17A 24385944 1039804 Positive_regulation TNF IL17A 24465207 3066054 Positive_regulation TNF IL17A 24586980 2928546 Positive_regulation TNF IL17A 24692552 1209095 Positive_regulation TNF IL17A 24742531 2188924 Positive_regulation TNF IL17A 24757287 1758249 Positive_regulation TNF IL17A 24788826 2959738 Positive_regulation TNF IL17A 24868166 2122980 Positive_regulation TNF IL17A 25111378 2996214 Positive_regulation TNF IL17A 25114378 1760395 Positive_regulation TNF IL17A 25114378 1760398 Positive_regulation TNF IL17A 25250801 3010010 Positive_regulation TNF IL17A 25295284 1623298 Positive_regulation TNF IL17A PMC2833605 134232 Positive_regulation TNF IL17A PMC2833823 134343 Positive_regulation TNF IL17B 22583555 1021155 Positive_regulation TNF IL17B 25152827 1083032 Positive_regulation TNF IL17C 25152827 1083033 Positive_regulation TNF IL17D 20604932 119377 Positive_regulation TNF IL17D 23049843 2699596 Positive_regulation TNF IL17D 23049843 2699600 Positive_regulation TNF IL17D 23049843 2699602 Positive_regulation TNF IL17D 23049843 2699603 Positive_regulation TNF IL17F 22030025 1065697 Positive_regulation TNF IL18 11076718 786939 Positive_regulation TNF IL18 11094408 98050 Positive_regulation TNF IL18 11489953 1520475 Positive_regulation TNF IL18 11489953 1520476 Positive_regulation TNF IL18 11489953 1520481 Positive_regulation TNF IL18 11489953 1520483 Positive_regulation TNF IL18 11489953 1520484 Positive_regulation TNF IL18 11489953 1520488 Positive_regulation TNF IL18 11489953 1520489 Positive_regulation TNF IL18 11879550 98721 Positive_regulation TNF IL18 12110156 99322 Positive_regulation TNF IL18 14979936 100106 Positive_regulation TNF IL18 1586593 426027 Positive_regulation TNF IL18 16258194 1740190 Positive_regulation TNF IL18 1643416 702452 Positive_regulation TNF IL18 16563174 105643 Positive_regulation TNF IL18 1692079 1542163 Positive_regulation TNF IL18 1717633 1543695 Positive_regulation TNF IL18 17923504 1547249 Positive_regulation TNF IL18 18475440 1743747 Positive_regulation TNF IL18 1911209 431549 Positive_regulation TNF IL18 19901996 1746771 Positive_regulation TNF IL18 2007858 1557276 Positive_regulation TNF IL18 2022925 1557556 Positive_regulation TNF IL18 2039696 434738 Positive_regulation TNF IL18 20634907 979125 Positive_regulation TNF IL18 21267358 742434 Positive_regulation TNF IL18 21716670 1222203 Positive_regulation TNF IL18 21756372 3112400 Positive_regulation TNF IL18 21801431 123357 Positive_regulation TNF IL18 21829352 3052603 Positive_regulation TNF IL18 2183871 437483 Positive_regulation TNF IL18 2183871 437540 Positive_regulation TNF IL18 22536153 3056414 Positive_regulation TNF IL18 22570532 1224118 Positive_regulation TNF IL18 2258696 1568172 Positive_regulation TNF IL18 22596175 729811 Positive_regulation TNF IL18 22596175 729813 Positive_regulation TNF IL18 22891066 903441 Positive_regulation TNF IL18 23516562 2768543 Positive_regulation TNF IL18 2373990 1572247 Positive_regulation TNF IL18 23758833 3163146 Positive_regulation TNF IL18 23762085 637545 Positive_regulation TNF IL18 23762085 637573 Positive_regulation TNF IL18 23915129 359216 Positive_regulation TNF IL18 2406363 1573678 Positive_regulation TNF IL18 24648814 1712221 Positive_regulation TNF IL18 24762050 132309 Positive_regulation TNF IL18 2499653 1576967 Positive_regulation TNF IL18 2642531 1577544 Positive_regulation TNF IL18 2659724 1577633 Positive_regulation TNF IL18 2769183 1577858 Positive_regulation TNF IL18 2785398 442900 Positive_regulation TNF IL18 2833558 1578512 Positive_regulation TNF IL18 3049617 1425438 Positive_regulation TNF IL18 3049617 1425534 Positive_regulation TNF IL18 3049617 1425535 Positive_regulation TNF IL18 3110354 1580031 Positive_regulation TNF IL18 3137305 1580344 Positive_regulation TNF IL18 3143799 1580399 Positive_regulation TNF IL18 3290384 1580765 Positive_regulation TNF IL18 3309124 1580883 Positive_regulation TNF IL18 3309124 1580938 Positive_regulation TNF IL18 3316469 1580998 Positive_regulation TNF IL18 3411293 1581164 Positive_regulation TNF IL18 3435706 443479 Positive_regulation TNF IL18 3491174 1583069 Positive_regulation TNF IL18 3494807 1583211 Positive_regulation TNF IL18 3494807 1583212 Positive_regulation TNF IL18 3494807 1583308 Positive_regulation TNF IL18 3572302 1583447 Positive_regulation TNF IL18 3598461 1583505 Positive_regulation TNF IL18 3819645 1583682 Positive_regulation TNF IL18 8260432 1030849 Positive_regulation TNF IL18 8426121 1595174 Positive_regulation TNF IL18 8478614 1595524 Positive_regulation TNF IL18 PMC2188223 1605373 Positive_regulation TNF IL19 1586593 426028 Positive_regulation TNF IL19 1643416 702453 Positive_regulation TNF IL19 1692079 1542164 Positive_regulation TNF IL19 1717633 1543696 Positive_regulation TNF IL19 18475440 1743748 Positive_regulation TNF IL19 1911209 431550 Positive_regulation TNF IL19 19901996 1746772 Positive_regulation TNF IL19 2007858 1557277 Positive_regulation TNF IL19 2022925 1557557 Positive_regulation TNF IL19 2039696 434739 Positive_regulation TNF IL19 21106488 1031250 Positive_regulation TNF IL19 21267358 742435 Positive_regulation TNF IL19 21801431 123358 Positive_regulation TNF IL19 21829352 3052604 Positive_regulation TNF IL19 2183871 437484 Positive_regulation TNF IL19 2183871 437541 Positive_regulation TNF IL19 22570532 1224119 Positive_regulation TNF IL19 2258696 1568173 Positive_regulation TNF IL19 22844641 1082590 Positive_regulation TNF IL19 23468852 2759817 Positive_regulation TNF IL19 23468852 2759822 Positive_regulation TNF IL19 23468852 2759824 Positive_regulation TNF IL19 23468852 2759829 Positive_regulation TNF IL19 2373990 1572248 Positive_regulation TNF IL19 23855879 1036673 Positive_regulation TNF IL19 2406363 1573679 Positive_regulation TNF IL19 2499653 1576968 Positive_regulation TNF IL19 2642531 1577545 Positive_regulation TNF IL19 2659724 1577634 Positive_regulation TNF IL19 2769183 1577859 Positive_regulation TNF IL19 2785398 442901 Positive_regulation TNF IL19 2833558 1578513 Positive_regulation TNF IL19 3049617 1425439 Positive_regulation TNF IL19 3049617 1425536 Positive_regulation TNF IL19 3049617 1425537 Positive_regulation TNF IL19 3110354 1580032 Positive_regulation TNF IL19 3137305 1580345 Positive_regulation TNF IL19 3143799 1580400 Positive_regulation TNF IL19 3290384 1580766 Positive_regulation TNF IL19 3309124 1580884 Positive_regulation TNF IL19 3309124 1580939 Positive_regulation TNF IL19 3316469 1580999 Positive_regulation TNF IL19 3411293 1581165 Positive_regulation TNF IL19 3435706 443480 Positive_regulation TNF IL19 3491174 1583070 Positive_regulation TNF IL19 3494807 1583213 Positive_regulation TNF IL19 3494807 1583214 Positive_regulation TNF IL19 3494807 1583309 Positive_regulation TNF IL19 3572302 1583448 Positive_regulation TNF IL19 3598461 1583506 Positive_regulation TNF IL19 3819645 1583683 Positive_regulation TNF IL19 8260432 1030850 Positive_regulation TNF IL19 8426121 1595175 Positive_regulation TNF IL19 8478614 1595525 Positive_regulation TNF IL19 PMC2188223 1605374 Positive_regulation TNF IL1A 10377187 1512014 Positive_regulation TNF IL1A 10748240 1515100 Positive_regulation TNF IL1A 11200364 1737601 Positive_regulation TNF IL1A 11219393 98350 Positive_regulation TNF IL1A 11257135 1519090 Positive_regulation TNF IL1A 12110136 99155 Positive_regulation TNF IL1A 15613243 3104181 Positive_regulation TNF IL1A 15642143 102395 Positive_regulation TNF IL1A 1586593 426008 Positive_regulation TNF IL1A 1586593 426009 Positive_regulation TNF IL1A 1586593 426029 Positive_regulation TNF IL1A 1586593 426068 Positive_regulation TNF IL1A 1586593 426069 Positive_regulation TNF IL1A 15946381 3105031 Positive_regulation TNF IL1A 16277701 104844 Positive_regulation TNF IL1A 16669999 3107215 Positive_regulation TNF IL1A 16684367 105981 Positive_regulation TNF IL1A 16684367 105982 Positive_regulation TNF IL1A 16684367 105983 Positive_regulation TNF IL1A 16800873 1722651 Positive_regulation TNF IL1A 16859503 106264 Positive_regulation TNF IL1A 16959029 1654959 Positive_regulation TNF IL1A 17559674 108398 Positive_regulation TNF IL1A 18202163 3177761 Positive_regulation TNF IL1A 18360651 3176745 Positive_regulation TNF IL1A 18472791 1766937 Positive_regulation TNF IL1A 18472950 1743292 Positive_regulation TNF IL1A 18475439 1743534 Positive_regulation TNF IL1A 18475751 1746331 Positive_regulation TNF IL1A 18587424 450882 Positive_regulation TNF IL1A 19327151 1897151 Positive_regulation TNF IL1A 19435506 113222 Positive_regulation TNF IL1A 19463182 352903 Positive_regulation TNF IL1A 19570027 137473 Positive_regulation TNF IL1A 19672457 1746653 Positive_regulation TNF IL1A 19734906 1952970 Positive_regulation TNF IL1A 19934004 711864 Positive_regulation TNF IL1A 20011631 1910220 Positive_regulation TNF IL1A 20195505 3046464 Positive_regulation TNF IL1A 20416261 3209777 Positive_regulation TNF IL1A 20463965 2449869 Positive_regulation TNF IL1A 20693346 716061 Positive_regulation TNF IL1A 20836881 508208 Positive_regulation TNF IL1A 20935647 1954500 Positive_regulation TNF IL1A 21152323 1090439 Positive_regulation TNF IL1A 21321416 1044978 Positive_regulation TNF IL1A 21410677 450518 Positive_regulation TNF IL1A 21424610 1668500 Positive_regulation TNF IL1A 21477368 3112037 Positive_regulation TNF IL1A 21477368 3112038 Positive_regulation TNF IL1A 21531876 1637151 Positive_regulation TNF IL1A 21547019 1675374 Positive_regulation TNF IL1A 2161898 1563989 Positive_regulation TNF IL1A 21629785 2525657 Positive_regulation TNF IL1A 21682898 122893 Positive_regulation TNF IL1A 21682898 122907 Positive_regulation TNF IL1A 21682898 122912 Positive_regulation TNF IL1A 21682898 122913 Positive_regulation TNF IL1A 21716670 1222204 Positive_regulation TNF IL1A 21738279 1713168 Positive_regulation TNF IL1A 21808655 813054 Positive_regulation TNF IL1A 21860543 1749378 Positive_regulation TNF IL1A 21977313 799198 Positive_regulation TNF IL1A 21978632 1697863 Positive_regulation TNF IL1A 22002242 488150 Positive_regulation TNF IL1A 22294049 1918686 Positive_regulation TNF IL1A 22319429 2295469 Positive_regulation TNF IL1A 22322095 1882590 Positive_regulation TNF IL1A 22419920 95172 Positive_regulation TNF IL1A 22455445 336079 Positive_regulation TNF IL1A 22529966 2620757 Positive_regulation TNF IL1A 22529966 2620770 Positive_regulation TNF IL1A 22545125 2623573 Positive_regulation TNF IL1A 22566778 3152659 Positive_regulation TNF IL1A 22615502 1044044 Positive_regulation TNF IL1A 22682420 126124 Positive_regulation TNF IL1A 22761877 2659056 Positive_regulation TNF IL1A 22792469 1690370 Positive_regulation TNF IL1A 22860122 2671793 Positive_regulation TNF IL1A 22860122 2671807 Positive_regulation TNF IL1A 22860122 2671808 Positive_regulation TNF IL1A 22909087 1626658 Positive_regulation TNF IL1A 22935594 30825 Positive_regulation TNF IL1A 23028407 2219737 Positive_regulation TNF IL1A 23028621 2691982 Positive_regulation TNF IL1A 23104095 1958316 Positive_regulation TNF IL1A 23118903 2712086 Positive_regulation TNF IL1A 23134577 127188 Positive_regulation TNF IL1A 23136547 1084284 Positive_regulation TNF IL1A 23208413 2110582 Positive_regulation TNF IL1A 23226468 2725132 Positive_regulation TNF IL1A 23238232 651944 Positive_regulation TNF IL1A 23285244 2733111 Positive_regulation TNF IL1A 23304632 1082736 Positive_regulation TNF IL1A 23488692 3129575 Positive_regulation TNF IL1A 23509747 180079 Positive_regulation TNF IL1A 23516523 2768198 Positive_regulation TNF IL1A 23516523 2768219 Positive_regulation TNF IL1A 23525523 1712123 Positive_regulation TNF IL1A 23567618 1642643 Positive_regulation TNF IL1A 23577207 2778596 Positive_regulation TNF IL1A 23613842 2782358 Positive_regulation TNF IL1A 23631691 3215582 Positive_regulation TNF IL1A 23634700 1666643 Positive_regulation TNF IL1A 23641196 866931 Positive_regulation TNF IL1A 23674954 1064304 Positive_regulation TNF IL1A 23737655 1753270 Positive_regulation TNF IL1A 23814544 684711 Positive_regulation TNF IL1A 23840908 2818790 Positive_regulation TNF IL1A 23840908 2818797 Positive_regulation TNF IL1A 23840908 2818817 Positive_regulation TNF IL1A 23840908 2818821 Positive_regulation TNF IL1A 23843682 1754003 Positive_regulation TNF IL1A 23889808 1627211 Positive_regulation TNF IL1A 23889808 1627670 Positive_regulation TNF IL1A 23962134 1050796 Positive_regulation TNF IL1A 24007463 537416 Positive_regulation TNF IL1A 24058610 2848242 Positive_regulation TNF IL1A 24073392 1078393 Positive_regulation TNF IL1A 24073392 1078397 Positive_regulation TNF IL1A 24141950 1991009 Positive_regulation TNF IL1A 24156755 380453 Positive_regulation TNF IL1A 24204851 2874439 Positive_regulation TNF IL1A 24228622 359364 Positive_regulation TNF IL1A 24249711 1158342 Positive_regulation TNF IL1A 24283517 130092 Positive_regulation TNF IL1A 24283517 130093 Positive_regulation TNF IL1A 24283517 130094 Positive_regulation TNF IL1A 24283517 130095 Positive_regulation TNF IL1A 24283517 130096 Positive_regulation TNF IL1A 24283517 130097 Positive_regulation TNF IL1A 24283517 130098 Positive_regulation TNF IL1A 24283517 130099 Positive_regulation TNF IL1A 24283517 130100 Positive_regulation TNF IL1A 24283517 130101 Positive_regulation TNF IL1A 24283517 130102 Positive_regulation TNF IL1A 24283517 130110 Positive_regulation TNF IL1A 24283517 130111 Positive_regulation TNF IL1A 24283517 130112 Positive_regulation TNF IL1A 24283517 130117 Positive_regulation TNF IL1A 24283517 130118 Positive_regulation TNF IL1A 24283517 130121 Positive_regulation TNF IL1A 24283517 130122 Positive_regulation TNF IL1A 24283517 130126 Positive_regulation TNF IL1A 24284399 1121777 Positive_regulation TNF IL1A 24324897 1150653 Positive_regulation TNF IL1A 24330807 1667416 Positive_regulation TNF IL1A 24330807 1667428 Positive_regulation TNF IL1A 24330807 1667442 Positive_regulation TNF IL1A 24330807 1667445 Positive_regulation TNF IL1A 24348193 3155618 Positive_regulation TNF IL1A 24348789 843948 Positive_regulation TNF IL1A 24348789 843954 Positive_regulation TNF IL1A 24349442 2898073 Positive_regulation TNF IL1A 24351869 1122544 Positive_regulation TNF IL1A 24397846 139163 Positive_regulation TNF IL1A 24438745 131355 Positive_regulation TNF IL1A 24446482 1415321 Positive_regulation TNF IL1A 24471071 3077306 Positive_regulation TNF IL1A 24490798 1667682 Positive_regulation TNF IL1A 24490798 1667692 Positive_regulation TNF IL1A 24490798 1667705 Positive_regulation TNF IL1A 24490798 1667706 Positive_regulation TNF IL1A 24568275 357524 Positive_regulation TNF IL1A 24595131 2930805 Positive_regulation TNF IL1A 24647690 2936310 Positive_regulation TNF IL1A 24647690 2936317 Positive_regulation TNF IL1A 24648814 1712228 Positive_regulation TNF IL1A 24705157 984957 Positive_regulation TNF IL1A 24705335 2949068 Positive_regulation TNF IL1A 24762050 132317 Positive_regulation TNF IL1A 24788826 2959739 Positive_regulation TNF IL1A 24830946 2970370 Positive_regulation TNF IL1A 24857913 1127091 Positive_regulation TNF IL1A 24883060 1074228 Positive_regulation TNF IL1A 24885494 396631 Positive_regulation TNF IL1A 24901233 2976444 Positive_regulation TNF IL1A 25057505 1622502 Positive_regulation TNF IL1A 25061260 1760235 Positive_regulation TNF IL1A 25104881 1760298 Positive_regulation TNF IL1A 25289073 845241 Positive_regulation TNF IL1A 25400917 1037329 Positive_regulation TNF IL1A 25412085 3028955 Positive_regulation TNF IL1A 25415055 177588 Positive_regulation TNF IL1A 25506235 1629228 Positive_regulation TNF IL1A 25552899 744122 Positive_regulation TNF IL1A 2647895 1577613 Positive_regulation TNF IL1A 2950198 1579171 Positive_regulation TNF IL1A 3351436 1581115 Positive_regulation TNF IL1A 3491174 1583109 Positive_regulation TNF IL1A 3494807 1583287 Positive_regulation TNF IL1A 3494807 1583290 Positive_regulation TNF IL1A 8101860 1594042 Positive_regulation TNF IL1A PMC2833524 134186 Positive_regulation TNF IL1A PMC3991031 2245467 Positive_regulation TNF IL1B 18553155 3090050 Positive_regulation TNF IL1B 20699000 257079 Positive_regulation TNF IL1B 24156755 380454 Positive_regulation TNF IL1B 24628956 347061 Positive_regulation TNF IL1B 25147565 1074706 Positive_regulation TNF IL1R1 23251037 1751075 Positive_regulation TNF IL1RN 12110136 99156 Positive_regulation TNF IL1RN 22095690 1033505 Positive_regulation TNF IL1RN 23908975 649291 Positive_regulation TNF IL1RN 23951204 2833684 Positive_regulation TNF IL1RN 25229476 3008037 Positive_regulation TNF IL2 10378358 3227964 Positive_regulation TNF IL2 10429670 1512069 Positive_regulation TNF IL2 10732751 416379 Positive_regulation TNF IL2 11781360 1522096 Positive_regulation TNF IL2 1328463 1528410 Positive_regulation TNF IL2 1457368 423654 Positive_regulation TNF IL2 1586593 426030 Positive_regulation TNF IL2 16287710 1538373 Positive_regulation TNF IL2 1643416 702454 Positive_regulation TNF IL2 1692079 1542165 Positive_regulation TNF IL2 1717633 1543697 Positive_regulation TNF IL2 17386115 626747 Positive_regulation TNF IL2 17386115 626748 Positive_regulation TNF IL2 18475440 1743749 Positive_regulation TNF IL2 18475462 1743836 Positive_regulation TNF IL2 1911209 431551 Positive_regulation TNF IL2 1955461 1367376 Positive_regulation TNF IL2 1972179 1556148 Positive_regulation TNF IL2 1985116 1556566 Positive_regulation TNF IL2 19901996 1746773 Positive_regulation TNF IL2 20041187 2435945 Positive_regulation TNF IL2 2007858 1557278 Positive_regulation TNF IL2 2022925 1557558 Positive_regulation TNF IL2 2039696 434740 Positive_regulation TNF IL2 21267358 742436 Positive_regulation TNF IL2 21801431 123359 Positive_regulation TNF IL2 21829352 3052605 Positive_regulation TNF IL2 2183871 437485 Positive_regulation TNF IL2 2183871 437542 Positive_regulation TNF IL2 2183871 437543 Positive_regulation TNF IL2 22523581 2620386 Positive_regulation TNF IL2 22523581 2620425 Positive_regulation TNF IL2 22570532 1224120 Positive_regulation TNF IL2 2258696 1568174 Positive_regulation TNF IL2 22957276 1154470 Positive_regulation TNF IL2 23704321 3126198 Positive_regulation TNF IL2 23705987 1699794 Positive_regulation TNF IL2 2373990 1572249 Positive_regulation TNF IL2 23801992 907931 Positive_regulation TNF IL2 2406363 1573680 Positive_regulation TNF IL2 24498569 2162994 Positive_regulation TNF IL2 2499653 1576969 Positive_regulation TNF IL2 25090613 2995129 Positive_regulation TNF IL2 2536067 1577278 Positive_regulation TNF IL2 2642531 1577546 Positive_regulation TNF IL2 2659724 1577635 Positive_regulation TNF IL2 2769183 1577860 Positive_regulation TNF IL2 2783332 1577896 Positive_regulation TNF IL2 2785398 442902 Positive_regulation TNF IL2 2788701 1578143 Positive_regulation TNF IL2 2833558 1578514 Positive_regulation TNF IL2 2903211 1578641 Positive_regulation TNF IL2 3049617 1425440 Positive_regulation TNF IL2 3049617 1425538 Positive_regulation TNF IL2 3049617 1425539 Positive_regulation TNF IL2 3110354 1580033 Positive_regulation TNF IL2 3137305 1580346 Positive_regulation TNF IL2 3143799 1580401 Positive_regulation TNF IL2 3290384 1580767 Positive_regulation TNF IL2 3309124 1580885 Positive_regulation TNF IL2 3309124 1580940 Positive_regulation TNF IL2 3316469 1581000 Positive_regulation TNF IL2 3411293 1581166 Positive_regulation TNF IL2 3435706 443481 Positive_regulation TNF IL2 3491174 1583071 Positive_regulation TNF IL2 3494807 1583215 Positive_regulation TNF IL2 3494807 1583216 Positive_regulation TNF IL2 3494807 1583310 Positive_regulation TNF IL2 3572302 1583449 Positive_regulation TNF IL2 3598461 1583507 Positive_regulation TNF IL2 3819645 1583684 Positive_regulation TNF IL2 7841036 444443 Positive_regulation TNF IL2 7841036 444444 Positive_regulation TNF IL2 8064221 1593878 Positive_regulation TNF IL2 8064221 1593917 Positive_regulation TNF IL2 8064221 1593924 Positive_regulation TNF IL2 8260432 1030851 Positive_regulation TNF IL2 8426121 1595176 Positive_regulation TNF IL2 8478614 1595526 Positive_regulation TNF IL2 8912533 445798 Positive_regulation TNF IL2 9652754 447275 Positive_regulation TNF IL2 PMC1972403 448082 Positive_regulation TNF IL2 PMC2188223 1605375 Positive_regulation TNF IL2 PMC3301785 660981 Positive_regulation TNF IL20 1586593 426031 Positive_regulation TNF IL20 1643416 702455 Positive_regulation TNF IL20 1692079 1542166 Positive_regulation TNF IL20 1717633 1543698 Positive_regulation TNF IL20 18475440 1743750 Positive_regulation TNF IL20 1911209 431552 Positive_regulation TNF IL20 19901996 1746774 Positive_regulation TNF IL20 2007858 1557279 Positive_regulation TNF IL20 2022925 1557559 Positive_regulation TNF IL20 2039696 434741 Positive_regulation TNF IL20 21267358 742437 Positive_regulation TNF IL20 21801431 123360 Positive_regulation TNF IL20 21829352 3052606 Positive_regulation TNF IL20 2183871 437486 Positive_regulation TNF IL20 2183871 437544 Positive_regulation TNF IL20 21844205 1564840 Positive_regulation TNF IL20 21844205 1564846 Positive_regulation TNF IL20 21844205 1564849 Positive_regulation TNF IL20 22570532 1224121 Positive_regulation TNF IL20 2258696 1568175 Positive_regulation TNF IL20 2373990 1572250 Positive_regulation TNF IL20 2406363 1573681 Positive_regulation TNF IL20 2499653 1576970 Positive_regulation TNF IL20 2642531 1577547 Positive_regulation TNF IL20 2659724 1577636 Positive_regulation TNF IL20 2769183 1577861 Positive_regulation TNF IL20 2785398 442903 Positive_regulation TNF IL20 2833558 1578515 Positive_regulation TNF IL20 3049617 1425441 Positive_regulation TNF IL20 3049617 1425540 Positive_regulation TNF IL20 3049617 1425541 Positive_regulation TNF IL20 3110354 1580034 Positive_regulation TNF IL20 3137305 1580347 Positive_regulation TNF IL20 3143799 1580402 Positive_regulation TNF IL20 3290384 1580768 Positive_regulation TNF IL20 3309124 1580886 Positive_regulation TNF IL20 3309124 1580941 Positive_regulation TNF IL20 3316469 1581001 Positive_regulation TNF IL20 3411293 1581167 Positive_regulation TNF IL20 3435706 443482 Positive_regulation TNF IL20 3491174 1583072 Positive_regulation TNF IL20 3494807 1583217 Positive_regulation TNF IL20 3494807 1583218 Positive_regulation TNF IL20 3494807 1583311 Positive_regulation TNF IL20 3572302 1583450 Positive_regulation TNF IL20 3598461 1583508 Positive_regulation TNF IL20 3819645 1583685 Positive_regulation TNF IL20 8260432 1030852 Positive_regulation TNF IL20 8426121 1595177 Positive_regulation TNF IL20 8478614 1595527 Positive_regulation TNF IL20 PMC2188223 1605376 Positive_regulation TNF IL21 1586593 426032 Positive_regulation TNF IL21 1643416 702456 Positive_regulation TNF IL21 1692079 1542167 Positive_regulation TNF IL21 1717633 1543699 Positive_regulation TNF IL21 18475440 1743751 Positive_regulation TNF IL21 1911209 431553 Positive_regulation TNF IL21 19901996 1746775 Positive_regulation TNF IL21 2007858 1557280 Positive_regulation TNF IL21 2022925 1557560 Positive_regulation TNF IL21 2039696 434742 Positive_regulation TNF IL21 21267358 742438 Positive_regulation TNF IL21 21801431 123361 Positive_regulation TNF IL21 21829352 3052607 Positive_regulation TNF IL21 2183871 437487 Positive_regulation TNF IL21 2183871 437545 Positive_regulation TNF IL21 22570532 1224122 Positive_regulation TNF IL21 2258696 1568176 Positive_regulation TNF IL21 23301223 89169 Positive_regulation TNF IL21 2373990 1572251 Positive_regulation TNF IL21 2406363 1573682 Positive_regulation TNF IL21 2499653 1576971 Positive_regulation TNF IL21 25251568 3010149 Positive_regulation TNF IL21 25251568 3010168 Positive_regulation TNF IL21 25251568 3010169 Positive_regulation TNF IL21 2642531 1577548 Positive_regulation TNF IL21 2659724 1577637 Positive_regulation TNF IL21 2769183 1577862 Positive_regulation TNF IL21 2785398 442904 Positive_regulation TNF IL21 2833558 1578516 Positive_regulation TNF IL21 3049617 1425442 Positive_regulation TNF IL21 3049617 1425542 Positive_regulation TNF IL21 3049617 1425543 Positive_regulation TNF IL21 3110354 1580035 Positive_regulation TNF IL21 3137305 1580348 Positive_regulation TNF IL21 3143799 1580403 Positive_regulation TNF IL21 3290384 1580769 Positive_regulation TNF IL21 3309124 1580887 Positive_regulation TNF IL21 3309124 1580942 Positive_regulation TNF IL21 3316469 1581002 Positive_regulation TNF IL21 3411293 1581168 Positive_regulation TNF IL21 3435706 443483 Positive_regulation TNF IL21 3491174 1583073 Positive_regulation TNF IL21 3494807 1583219 Positive_regulation TNF IL21 3494807 1583220 Positive_regulation TNF IL21 3494807 1583312 Positive_regulation TNF IL21 3572302 1583451 Positive_regulation TNF IL21 3598461 1583509 Positive_regulation TNF IL21 3819645 1583686 Positive_regulation TNF IL21 8260432 1030853 Positive_regulation TNF IL21 8426121 1595178 Positive_regulation TNF IL21 8478614 1595528 Positive_regulation TNF IL21 PMC2188223 1605377 Positive_regulation TNF IL22 1586593 426014 Positive_regulation TNF IL22 1643416 702439 Positive_regulation TNF IL22 1692079 1542150 Positive_regulation TNF IL22 1717633 1543682 Positive_regulation TNF IL22 18475440 1743734 Positive_regulation TNF IL22 1911209 431535 Positive_regulation TNF IL22 19503799 1746610 Positive_regulation TNF IL22 19901996 1746758 Positive_regulation TNF IL22 20049260 1043893 Positive_regulation TNF IL22 2007858 1557262 Positive_regulation TNF IL22 2022925 1557543 Positive_regulation TNF IL22 2039696 434725 Positive_regulation TNF IL22 21267358 742421 Positive_regulation TNF IL22 21801431 123344 Positive_regulation TNF IL22 21829352 3052587 Positive_regulation TNF IL22 2183871 437468 Positive_regulation TNF IL22 2183871 437527 Positive_regulation TNF IL22 21897855 2549855 Positive_regulation TNF IL22 22570532 1224105 Positive_regulation TNF IL22 2258696 1568159 Positive_regulation TNF IL22 23197904 88220 Positive_regulation TNF IL22 23386905 1239746 Positive_regulation TNF IL22 2373990 1572234 Positive_regulation TNF IL22 23956763 638366 Positive_regulation TNF IL22 2406363 1573665 Positive_regulation TNF IL22 24465207 3066053 Positive_regulation TNF IL22 24568275 357520 Positive_regulation TNF IL22 24623532 1050581 Positive_regulation TNF IL22 24744763 912249 Positive_regulation TNF IL22 2499653 1576954 Positive_regulation TNF IL22 25061260 1760229 Positive_regulation TNF IL22 2642531 1577531 Positive_regulation TNF IL22 2659724 1577620 Positive_regulation TNF IL22 2769183 1577845 Positive_regulation TNF IL22 2785398 442887 Positive_regulation TNF IL22 2833558 1578499 Positive_regulation TNF IL22 3049617 1425425 Positive_regulation TNF IL22 3049617 1425508 Positive_regulation TNF IL22 3049617 1425509 Positive_regulation TNF IL22 3110354 1580018 Positive_regulation TNF IL22 3137305 1580331 Positive_regulation TNF IL22 3143799 1580386 Positive_regulation TNF IL22 3290384 1580752 Positive_regulation TNF IL22 3309124 1580870 Positive_regulation TNF IL22 3309124 1580925 Positive_regulation TNF IL22 3316469 1580985 Positive_regulation TNF IL22 3411293 1581151 Positive_regulation TNF IL22 3435706 443466 Positive_regulation TNF IL22 3491174 1583056 Positive_regulation TNF IL22 3494807 1583185 Positive_regulation TNF IL22 3494807 1583186 Positive_regulation TNF IL22 3494807 1583295 Positive_regulation TNF IL22 3572302 1583434 Positive_regulation TNF IL22 3598461 1583492 Positive_regulation TNF IL22 3819645 1583669 Positive_regulation TNF IL22 8260432 1030836 Positive_regulation TNF IL22 8426121 1595161 Positive_regulation TNF IL22 8478614 1595511 Positive_regulation TNF IL22 PMC2188223 1605360 Positive_regulation TNF IL23A 17306038 107815 Positive_regulation TNF IL23A 19815670 3126152 Positive_regulation TNF IL23A 22269588 1660768 Positive_regulation TNF IL23A 22417709 125166 Positive_regulation TNF IL23A 22624013 2644751 Positive_regulation TNF IL23A 23301223 89167 Positive_regulation TNF IL23A 23316190 905570 Positive_regulation TNF IL23A 23319986 95352 Positive_regulation TNF IL23A 24023721 2843393 Positive_regulation TNF IL23A 24683394 3070926 Positive_regulation TNF IL23A 25015728 2195838 Positive_regulation TNF IL23A 25061260 1760230 Positive_regulation TNF IL23A 25105894 2996094 Positive_regulation TNF IL24 1586593 426012 Positive_regulation TNF IL24 1643416 702437 Positive_regulation TNF IL24 1692079 1542148 Positive_regulation TNF IL24 1717633 1543680 Positive_regulation TNF IL24 18475440 1743732 Positive_regulation TNF IL24 1911209 431533 Positive_regulation TNF IL24 19901996 1746756 Positive_regulation TNF IL24 20072629 2437017 Positive_regulation TNF IL24 2007858 1557260 Positive_regulation TNF IL24 2022925 1557541 Positive_regulation TNF IL24 2039696 434723 Positive_regulation TNF IL24 21267358 742419 Positive_regulation TNF IL24 21801431 123342 Positive_regulation TNF IL24 21829352 3052585 Positive_regulation TNF IL24 2183871 437466 Positive_regulation TNF IL24 2183871 437525 Positive_regulation TNF IL24 22570532 1224103 Positive_regulation TNF IL24 2258696 1568157 Positive_regulation TNF IL24 2373990 1572232 Positive_regulation TNF IL24 2406363 1573663 Positive_regulation TNF IL24 2499653 1576952 Positive_regulation TNF IL24 2642531 1577529 Positive_regulation TNF IL24 2659724 1577618 Positive_regulation TNF IL24 2769183 1577843 Positive_regulation TNF IL24 2785398 442885 Positive_regulation TNF IL24 2833558 1578497 Positive_regulation TNF IL24 3049617 1425423 Positive_regulation TNF IL24 3049617 1425504 Positive_regulation TNF IL24 3049617 1425505 Positive_regulation TNF IL24 3110354 1580016 Positive_regulation TNF IL24 3137305 1580329 Positive_regulation TNF IL24 3143799 1580384 Positive_regulation TNF IL24 3290384 1580750 Positive_regulation TNF IL24 3309124 1580868 Positive_regulation TNF IL24 3309124 1580923 Positive_regulation TNF IL24 3316469 1580983 Positive_regulation TNF IL24 3411293 1581149 Positive_regulation TNF IL24 3435706 443464 Positive_regulation TNF IL24 3491174 1583054 Positive_regulation TNF IL24 3494807 1583181 Positive_regulation TNF IL24 3494807 1583182 Positive_regulation TNF IL24 3494807 1583293 Positive_regulation TNF IL24 3572302 1583432 Positive_regulation TNF IL24 3598461 1583490 Positive_regulation TNF IL24 3819645 1583667 Positive_regulation TNF IL24 8260432 1030834 Positive_regulation TNF IL24 8426121 1595159 Positive_regulation TNF IL24 8478614 1595509 Positive_regulation TNF IL24 PMC2188223 1605358 Positive_regulation TNF IL25 1586593 426013 Positive_regulation TNF IL25 1643416 702438 Positive_regulation TNF IL25 1692079 1542149 Positive_regulation TNF IL25 1717633 1543681 Positive_regulation TNF IL25 18475440 1743733 Positive_regulation TNF IL25 1911209 431534 Positive_regulation TNF IL25 19901996 1746757 Positive_regulation TNF IL25 2007858 1557261 Positive_regulation TNF IL25 2022925 1557542 Positive_regulation TNF IL25 2039696 434724 Positive_regulation TNF IL25 21267358 742420 Positive_regulation TNF IL25 21801431 123343 Positive_regulation TNF IL25 21829352 3052586 Positive_regulation TNF IL25 2183871 437467 Positive_regulation TNF IL25 2183871 437526 Positive_regulation TNF IL25 22570532 1224104 Positive_regulation TNF IL25 2258696 1568158 Positive_regulation TNF IL25 2373990 1572233 Positive_regulation TNF IL25 2406363 1573664 Positive_regulation TNF IL25 2499653 1576953 Positive_regulation TNF IL25 2642531 1577530 Positive_regulation TNF IL25 2659724 1577619 Positive_regulation TNF IL25 2769183 1577844 Positive_regulation TNF IL25 2785398 442886 Positive_regulation TNF IL25 2833558 1578498 Positive_regulation TNF IL25 3049617 1425424 Positive_regulation TNF IL25 3049617 1425506 Positive_regulation TNF IL25 3049617 1425507 Positive_regulation TNF IL25 3110354 1580017 Positive_regulation TNF IL25 3137305 1580330 Positive_regulation TNF IL25 3143799 1580385 Positive_regulation TNF IL25 3290384 1580751 Positive_regulation TNF IL25 3309124 1580869 Positive_regulation TNF IL25 3309124 1580924 Positive_regulation TNF IL25 3316469 1580984 Positive_regulation TNF IL25 3411293 1581150 Positive_regulation TNF IL25 3435706 443465 Positive_regulation TNF IL25 3491174 1583055 Positive_regulation TNF IL25 3494807 1583183 Positive_regulation TNF IL25 3494807 1583184 Positive_regulation TNF IL25 3494807 1583294 Positive_regulation TNF IL25 3572302 1583433 Positive_regulation TNF IL25 3598461 1583491 Positive_regulation TNF IL25 3819645 1583668 Positive_regulation TNF IL25 8260432 1030835 Positive_regulation TNF IL25 8426121 1595160 Positive_regulation TNF IL25 8478614 1595510 Positive_regulation TNF IL25 PMC2188223 1605359 Positive_regulation TNF IL26 1586593 426018 Positive_regulation TNF IL26 1643416 702443 Positive_regulation TNF IL26 1692079 1542154 Positive_regulation TNF IL26 1717633 1543686 Positive_regulation TNF IL26 18475440 1743738 Positive_regulation TNF IL26 1911209 431539 Positive_regulation TNF IL26 19901996 1746762 Positive_regulation TNF IL26 2007858 1557266 Positive_regulation TNF IL26 2022925 1557547 Positive_regulation TNF IL26 2039696 434729 Positive_regulation TNF IL26 21267358 742425 Positive_regulation TNF IL26 21801431 123348 Positive_regulation TNF IL26 21829352 3052591 Positive_regulation TNF IL26 2183871 437472 Positive_regulation TNF IL26 2183871 437531 Positive_regulation TNF IL26 22570532 1224109 Positive_regulation TNF IL26 2258696 1568163 Positive_regulation TNF IL26 23055831 2280426 Positive_regulation TNF IL26 23055831 2280438 Positive_regulation TNF IL26 2373990 1572238 Positive_regulation TNF IL26 2406363 1573669 Positive_regulation TNF IL26 2499653 1576958 Positive_regulation TNF IL26 2642531 1577535 Positive_regulation TNF IL26 2659724 1577624 Positive_regulation TNF IL26 2769183 1577849 Positive_regulation TNF IL26 2785398 442891 Positive_regulation TNF IL26 2833558 1578503 Positive_regulation TNF IL26 3049617 1425429 Positive_regulation TNF IL26 3049617 1425516 Positive_regulation TNF IL26 3049617 1425517 Positive_regulation TNF IL26 3110354 1580022 Positive_regulation TNF IL26 3137305 1580335 Positive_regulation TNF IL26 3143799 1580390 Positive_regulation TNF IL26 3290384 1580756 Positive_regulation TNF IL26 3309124 1580874 Positive_regulation TNF IL26 3309124 1580929 Positive_regulation TNF IL26 3316469 1580989 Positive_regulation TNF IL26 3411293 1581155 Positive_regulation TNF IL26 3435706 443470 Positive_regulation TNF IL26 3491174 1583060 Positive_regulation TNF IL26 3494807 1583193 Positive_regulation TNF IL26 3494807 1583194 Positive_regulation TNF IL26 3494807 1583299 Positive_regulation TNF IL26 3572302 1583438 Positive_regulation TNF IL26 3598461 1583496 Positive_regulation TNF IL26 3819645 1583673 Positive_regulation TNF IL26 8260432 1030840 Positive_regulation TNF IL26 8426121 1595165 Positive_regulation TNF IL26 8478614 1595515 Positive_regulation TNF IL26 PMC2188223 1605364 Positive_regulation TNF IL27 1586593 426019 Positive_regulation TNF IL27 1643416 702444 Positive_regulation TNF IL27 1692079 1542155 Positive_regulation TNF IL27 1717633 1543687 Positive_regulation TNF IL27 18475440 1743739 Positive_regulation TNF IL27 1911209 431540 Positive_regulation TNF IL27 19901996 1746763 Positive_regulation TNF IL27 2007858 1557267 Positive_regulation TNF IL27 2022925 1557548 Positive_regulation TNF IL27 2039696 434730 Positive_regulation TNF IL27 21267358 742426 Positive_regulation TNF IL27 21801431 123349 Positive_regulation TNF IL27 21829352 3052592 Positive_regulation TNF IL27 2183871 437473 Positive_regulation TNF IL27 2183871 437532 Positive_regulation TNF IL27 22570532 1224110 Positive_regulation TNF IL27 2258696 1568164 Positive_regulation TNF IL27 2373990 1572239 Positive_regulation TNF IL27 2406363 1573670 Positive_regulation TNF IL27 2499653 1576959 Positive_regulation TNF IL27 2642531 1577536 Positive_regulation TNF IL27 2659724 1577625 Positive_regulation TNF IL27 2769183 1577850 Positive_regulation TNF IL27 2785398 442892 Positive_regulation TNF IL27 2833558 1578504 Positive_regulation TNF IL27 3049617 1425430 Positive_regulation TNF IL27 3049617 1425518 Positive_regulation TNF IL27 3049617 1425519 Positive_regulation TNF IL27 3110354 1580023 Positive_regulation TNF IL27 3137305 1580336 Positive_regulation TNF IL27 3143799 1580391 Positive_regulation TNF IL27 3290384 1580757 Positive_regulation TNF IL27 3309124 1580875 Positive_regulation TNF IL27 3309124 1580930 Positive_regulation TNF IL27 3316469 1580990 Positive_regulation TNF IL27 3411293 1581156 Positive_regulation TNF IL27 3435706 443471 Positive_regulation TNF IL27 3491174 1583061 Positive_regulation TNF IL27 3494807 1583195 Positive_regulation TNF IL27 3494807 1583196 Positive_regulation TNF IL27 3494807 1583300 Positive_regulation TNF IL27 3572302 1583439 Positive_regulation TNF IL27 3598461 1583497 Positive_regulation TNF IL27 3819645 1583674 Positive_regulation TNF IL27 8260432 1030841 Positive_regulation TNF IL27 8426121 1595166 Positive_regulation TNF IL27 8478614 1595516 Positive_regulation TNF IL27 PMC2188223 1605365 Positive_regulation TNF IL2RA 21124839 2484181 Positive_regulation TNF IL2RA 9348317 1601933 Positive_regulation TNF IL2RB 19570027 137474 Positive_regulation TNF IL2RB 8666940 1597448 Positive_regulation TNF IL2RG 24740375 2954696 Positive_regulation TNF IL3 1586593 426033 Positive_regulation TNF IL3 1643416 702457 Positive_regulation TNF IL3 1692079 1542168 Positive_regulation TNF IL3 1717633 1543700 Positive_regulation TNF IL3 18475440 1743752 Positive_regulation TNF IL3 1911209 431554 Positive_regulation TNF IL3 19901996 1746776 Positive_regulation TNF IL3 2007858 1557281 Positive_regulation TNF IL3 2022925 1557561 Positive_regulation TNF IL3 2039696 434743 Positive_regulation TNF IL3 21267358 742439 Positive_regulation TNF IL3 21801431 123362 Positive_regulation TNF IL3 21829352 3052608 Positive_regulation TNF IL3 2183871 437488 Positive_regulation TNF IL3 2183871 437546 Positive_regulation TNF IL3 22570532 1224123 Positive_regulation TNF IL3 2258696 1568177 Positive_regulation TNF IL3 2373990 1572252 Positive_regulation TNF IL3 2406363 1573683 Positive_regulation TNF IL3 2499653 1576972 Positive_regulation TNF IL3 25144736 3001155 Positive_regulation TNF IL3 2642531 1577549 Positive_regulation TNF IL3 2659724 1577638 Positive_regulation TNF IL3 2769183 1577863 Positive_regulation TNF IL3 2785398 442905 Positive_regulation TNF IL3 2833558 1578517 Positive_regulation TNF IL3 3049617 1425443 Positive_regulation TNF IL3 3049617 1425544 Positive_regulation TNF IL3 3049617 1425545 Positive_regulation TNF IL3 3049913 1579816 Positive_regulation TNF IL3 3110354 1580036 Positive_regulation TNF IL3 3137305 1580349 Positive_regulation TNF IL3 3143799 1580404 Positive_regulation TNF IL3 3290384 1580770 Positive_regulation TNF IL3 3309124 1580888 Positive_regulation TNF IL3 3309124 1580943 Positive_regulation TNF IL3 3316469 1581003 Positive_regulation TNF IL3 3411293 1581169 Positive_regulation TNF IL3 3435706 443484 Positive_regulation TNF IL3 3491174 1583074 Positive_regulation TNF IL3 3494807 1583221 Positive_regulation TNF IL3 3494807 1583222 Positive_regulation TNF IL3 3494807 1583313 Positive_regulation TNF IL3 3572302 1583452 Positive_regulation TNF IL3 3598461 1583510 Positive_regulation TNF IL3 3819645 1583687 Positive_regulation TNF IL3 8260432 1030854 Positive_regulation TNF IL3 8426121 1595179 Positive_regulation TNF IL3 8478614 1595529 Positive_regulation TNF IL3 PMC2188223 1605378 Positive_regulation TNF IL31 1586593 426020 Positive_regulation TNF IL31 1643416 702445 Positive_regulation TNF IL31 1692079 1542156 Positive_regulation TNF IL31 1717633 1543688 Positive_regulation TNF IL31 18475440 1743740 Positive_regulation TNF IL31 1911209 431541 Positive_regulation TNF IL31 19901996 1746764 Positive_regulation TNF IL31 2007858 1557268 Positive_regulation TNF IL31 2022925 1557549 Positive_regulation TNF IL31 2039696 434731 Positive_regulation TNF IL31 21267358 742427 Positive_regulation TNF IL31 21801431 123350 Positive_regulation TNF IL31 21829352 3052593 Positive_regulation TNF IL31 2183871 437474 Positive_regulation TNF IL31 2183871 437533 Positive_regulation TNF IL31 22570532 1224111 Positive_regulation TNF IL31 2258696 1568165 Positive_regulation TNF IL31 2373990 1572240 Positive_regulation TNF IL31 2406363 1573671 Positive_regulation TNF IL31 2499653 1576960 Positive_regulation TNF IL31 2642531 1577537 Positive_regulation TNF IL31 2659724 1577626 Positive_regulation TNF IL31 2769183 1577851 Positive_regulation TNF IL31 2785398 442893 Positive_regulation TNF IL31 2833558 1578505 Positive_regulation TNF IL31 3049617 1425431 Positive_regulation TNF IL31 3049617 1425520 Positive_regulation TNF IL31 3049617 1425521 Positive_regulation TNF IL31 3110354 1580024 Positive_regulation TNF IL31 3137305 1580337 Positive_regulation TNF IL31 3143799 1580392 Positive_regulation TNF IL31 3290384 1580758 Positive_regulation TNF IL31 3309124 1580876 Positive_regulation TNF IL31 3309124 1580931 Positive_regulation TNF IL31 3316469 1580991 Positive_regulation TNF IL31 3411293 1581157 Positive_regulation TNF IL31 3435706 443472 Positive_regulation TNF IL31 3491174 1583062 Positive_regulation TNF IL31 3494807 1583197 Positive_regulation TNF IL31 3494807 1583198 Positive_regulation TNF IL31 3494807 1583301 Positive_regulation TNF IL31 3572302 1583440 Positive_regulation TNF IL31 3598461 1583498 Positive_regulation TNF IL31 3819645 1583675 Positive_regulation TNF IL31 8260432 1030842 Positive_regulation TNF IL31 8426121 1595167 Positive_regulation TNF IL31 8478614 1595517 Positive_regulation TNF IL31 PMC2188223 1605366 Positive_regulation TNF IL32 1586593 426017 Positive_regulation TNF IL32 1643416 702442 Positive_regulation TNF IL32 1692079 1542153 Positive_regulation TNF IL32 1717633 1543685 Positive_regulation TNF IL32 18475440 1743737 Positive_regulation TNF IL32 1911209 431538 Positive_regulation TNF IL32 19901996 1746761 Positive_regulation TNF IL32 2007858 1557265 Positive_regulation TNF IL32 2022925 1557546 Positive_regulation TNF IL32 2039696 434728 Positive_regulation TNF IL32 21075446 2252757 Positive_regulation TNF IL32 21108840 1657440 Positive_regulation TNF IL32 21108840 1657442 Positive_regulation TNF IL32 21267358 742424 Positive_regulation TNF IL32 21760628 487587 Positive_regulation TNF IL32 21801431 123347 Positive_regulation TNF IL32 21829352 3052590 Positive_regulation TNF IL32 2183871 437471 Positive_regulation TNF IL32 2183871 437530 Positive_regulation TNF IL32 22570532 1224108 Positive_regulation TNF IL32 2258696 1568162 Positive_regulation TNF IL32 23148518 640130 Positive_regulation TNF IL32 23148681 127273 Positive_regulation TNF IL32 23190696 127465 Positive_regulation TNF IL32 23703385 561851 Positive_regulation TNF IL32 2373990 1572237 Positive_regulation TNF IL32 2406363 1573668 Positive_regulation TNF IL32 24884781 357558 Positive_regulation TNF IL32 24884781 357559 Positive_regulation TNF IL32 24884781 357566 Positive_regulation TNF IL32 24884781 357567 Positive_regulation TNF IL32 24884781 357573 Positive_regulation TNF IL32 2499653 1576957 Positive_regulation TNF IL32 25386048 1763152 Positive_regulation TNF IL32 25462570 3031233 Positive_regulation TNF IL32 2642531 1577534 Positive_regulation TNF IL32 2659724 1577623 Positive_regulation TNF IL32 2769183 1577848 Positive_regulation TNF IL32 2785398 442890 Positive_regulation TNF IL32 2833558 1578502 Positive_regulation TNF IL32 3049617 1425428 Positive_regulation TNF IL32 3049617 1425514 Positive_regulation TNF IL32 3049617 1425515 Positive_regulation TNF IL32 3110354 1580021 Positive_regulation TNF IL32 3137305 1580334 Positive_regulation TNF IL32 3143799 1580389 Positive_regulation TNF IL32 3290384 1580755 Positive_regulation TNF IL32 3309124 1580873 Positive_regulation TNF IL32 3309124 1580928 Positive_regulation TNF IL32 3316469 1580988 Positive_regulation TNF IL32 3411293 1581154 Positive_regulation TNF IL32 3435706 443469 Positive_regulation TNF IL32 3491174 1583059 Positive_regulation TNF IL32 3494807 1583191 Positive_regulation TNF IL32 3494807 1583192 Positive_regulation TNF IL32 3494807 1583298 Positive_regulation TNF IL32 3572302 1583437 Positive_regulation TNF IL32 3598461 1583495 Positive_regulation TNF IL32 3819645 1583672 Positive_regulation TNF IL32 8260432 1030839 Positive_regulation TNF IL32 8426121 1595164 Positive_regulation TNF IL32 8478614 1595514 Positive_regulation TNF IL32 PMC2188223 1605363 Positive_regulation TNF IL33 1586593 426016 Positive_regulation TNF IL33 1643416 702441 Positive_regulation TNF IL33 1692079 1542152 Positive_regulation TNF IL33 1717633 1543684 Positive_regulation TNF IL33 18475440 1743736 Positive_regulation TNF IL33 1911209 431537 Positive_regulation TNF IL33 19519923 113518 Positive_regulation TNF IL33 19901996 1746760 Positive_regulation TNF IL33 2007858 1557264 Positive_regulation TNF IL33 2022925 1557545 Positive_regulation TNF IL33 2039696 434727 Positive_regulation TNF IL33 20689814 2457836 Positive_regulation TNF IL33 21267358 742423 Positive_regulation TNF IL33 21801431 123346 Positive_regulation TNF IL33 21829352 3052589 Positive_regulation TNF IL33 2183871 437470 Positive_regulation TNF IL33 2183871 437529 Positive_regulation TNF IL33 22566963 900596 Positive_regulation TNF IL33 22566963 900616 Positive_regulation TNF IL33 22570532 1224107 Positive_regulation TNF IL33 2258696 1568161 Positive_regulation TNF IL33 23028861 2693475 Positive_regulation TNF IL33 23028861 2693478 Positive_regulation TNF IL33 23062310 856166 Positive_regulation TNF IL33 23301222 89163 Positive_regulation TNF IL33 23567618 1642612 Positive_regulation TNF IL33 23567618 1642618 Positive_regulation TNF IL33 23567618 1642645 Positive_regulation TNF IL33 23567618 1642649 Positive_regulation TNF IL33 23585867 2778958 Positive_regulation TNF IL33 23585867 2778967 Positive_regulation TNF IL33 2373990 1572236 Positive_regulation TNF IL33 2406363 1573667 Positive_regulation TNF IL33 24151520 638784 Positive_regulation TNF IL33 2499653 1576956 Positive_regulation TNF IL33 25032216 194826 Positive_regulation TNF IL33 2642531 1577533 Positive_regulation TNF IL33 2659724 1577622 Positive_regulation TNF IL33 2769183 1577847 Positive_regulation TNF IL33 2785398 442889 Positive_regulation TNF IL33 2833558 1578501 Positive_regulation TNF IL33 3049617 1425427 Positive_regulation TNF IL33 3049617 1425512 Positive_regulation TNF IL33 3049617 1425513 Positive_regulation TNF IL33 3110354 1580020 Positive_regulation TNF IL33 3137305 1580333 Positive_regulation TNF IL33 3143799 1580388 Positive_regulation TNF IL33 3290384 1580754 Positive_regulation TNF IL33 3309124 1580872 Positive_regulation TNF IL33 3309124 1580927 Positive_regulation TNF IL33 3316469 1580987 Positive_regulation TNF IL33 3411293 1581153 Positive_regulation TNF IL33 3435706 443468 Positive_regulation TNF IL33 3491174 1583058 Positive_regulation TNF IL33 3494807 1583189 Positive_regulation TNF IL33 3494807 1583190 Positive_regulation TNF IL33 3494807 1583297 Positive_regulation TNF IL33 3572302 1583436 Positive_regulation TNF IL33 3598461 1583494 Positive_regulation TNF IL33 3819645 1583671 Positive_regulation TNF IL33 8260432 1030838 Positive_regulation TNF IL33 8426121 1595163 Positive_regulation TNF IL33 8478614 1595513 Positive_regulation TNF IL33 PMC2188223 1605362 Positive_regulation TNF IL34 1586593 426021 Positive_regulation TNF IL34 1643416 702446 Positive_regulation TNF IL34 1692079 1542157 Positive_regulation TNF IL34 1717633 1543689 Positive_regulation TNF IL34 18475440 1743741 Positive_regulation TNF IL34 1911209 431543 Positive_regulation TNF IL34 19901996 1746765 Positive_regulation TNF IL34 2007858 1557270 Positive_regulation TNF IL34 2022925 1557550 Positive_regulation TNF IL34 2039696 434732 Positive_regulation TNF IL34 21267358 742428 Positive_regulation TNF IL34 21801431 123351 Positive_regulation TNF IL34 21829352 3052594 Positive_regulation TNF IL34 2183871 437477 Positive_regulation TNF IL34 2183871 437534 Positive_regulation TNF IL34 22570532 1224112 Positive_regulation TNF IL34 2258696 1568166 Positive_regulation TNF IL34 2373990 1572241 Positive_regulation TNF IL34 2406363 1573672 Positive_regulation TNF IL34 24970360 1886465 Positive_regulation TNF IL34 2499653 1576961 Positive_regulation TNF IL34 2642531 1577538 Positive_regulation TNF IL34 2659724 1577627 Positive_regulation TNF IL34 2769183 1577852 Positive_regulation TNF IL34 2785398 442894 Positive_regulation TNF IL34 2833558 1578506 Positive_regulation TNF IL34 3049617 1425432 Positive_regulation TNF IL34 3049617 1425522 Positive_regulation TNF IL34 3049617 1425523 Positive_regulation TNF IL34 3110354 1580025 Positive_regulation TNF IL34 3137305 1580338 Positive_regulation TNF IL34 3143799 1580393 Positive_regulation TNF IL34 3290384 1580759 Positive_regulation TNF IL34 3309124 1580877 Positive_regulation TNF IL34 3309124 1580932 Positive_regulation TNF IL34 3316469 1580992 Positive_regulation TNF IL34 3411293 1581158 Positive_regulation TNF IL34 3435706 443473 Positive_regulation TNF IL34 3491174 1583063 Positive_regulation TNF IL34 3494807 1583199 Positive_regulation TNF IL34 3494807 1583200 Positive_regulation TNF IL34 3494807 1583302 Positive_regulation TNF IL34 3572302 1583441 Positive_regulation TNF IL34 3598461 1583499 Positive_regulation TNF IL34 3819645 1583676 Positive_regulation TNF IL34 8260432 1030843 Positive_regulation TNF IL34 8426121 1595168 Positive_regulation TNF IL34 8478614 1595518 Positive_regulation TNF IL34 PMC2188223 1605367 Positive_regulation TNF IL37 1586593 426015 Positive_regulation TNF IL37 1643416 702440 Positive_regulation TNF IL37 1692079 1542151 Positive_regulation TNF IL37 1717633 1543683 Positive_regulation TNF IL37 18475440 1743735 Positive_regulation TNF IL37 1911209 431536 Positive_regulation TNF IL37 19901996 1746759 Positive_regulation TNF IL37 2007858 1557263 Positive_regulation TNF IL37 2022925 1557544 Positive_regulation TNF IL37 2039696 434726 Positive_regulation TNF IL37 20935647 1954507 Positive_regulation TNF IL37 21267358 742422 Positive_regulation TNF IL37 21801431 123345 Positive_regulation TNF IL37 21829352 3052588 Positive_regulation TNF IL37 2183871 437469 Positive_regulation TNF IL37 2183871 437528 Positive_regulation TNF IL37 22570532 1224106 Positive_regulation TNF IL37 2258696 1568160 Positive_regulation TNF IL37 2373990 1572235 Positive_regulation TNF IL37 2406363 1573666 Positive_regulation TNF IL37 2499653 1576955 Positive_regulation TNF IL37 2642531 1577532 Positive_regulation TNF IL37 2659724 1577621 Positive_regulation TNF IL37 2769183 1577846 Positive_regulation TNF IL37 2785398 442888 Positive_regulation TNF IL37 2833558 1578500 Positive_regulation TNF IL37 3049617 1425426 Positive_regulation TNF IL37 3049617 1425510 Positive_regulation TNF IL37 3049617 1425511 Positive_regulation TNF IL37 3110354 1580019 Positive_regulation TNF IL37 3137305 1580332 Positive_regulation TNF IL37 3143799 1580387 Positive_regulation TNF IL37 3290384 1580753 Positive_regulation TNF IL37 3309124 1580871 Positive_regulation TNF IL37 3309124 1580926 Positive_regulation TNF IL37 3316469 1580986 Positive_regulation TNF IL37 3411293 1581152 Positive_regulation TNF IL37 3435706 443467 Positive_regulation TNF IL37 3491174 1583057 Positive_regulation TNF IL37 3494807 1583187 Positive_regulation TNF IL37 3494807 1583188 Positive_regulation TNF IL37 3494807 1583296 Positive_regulation TNF IL37 3572302 1583435 Positive_regulation TNF IL37 3598461 1583493 Positive_regulation TNF IL37 3819645 1583670 Positive_regulation TNF IL37 8260432 1030837 Positive_regulation TNF IL37 8426121 1595162 Positive_regulation TNF IL37 8478614 1595512 Positive_regulation TNF IL37 PMC2188223 1605361 Positive_regulation TNF IL4 10704085 1736965 Positive_regulation TNF IL4 11781360 1522097 Positive_regulation TNF IL4 11850581 1632877 Positive_regulation TNF IL4 12061423 1738138 Positive_regulation TNF IL4 14638848 1529872 Positive_regulation TNF IL4 14638848 1529886 Positive_regulation TNF IL4 1586593 426034 Positive_regulation TNF IL4 1643416 702458 Positive_regulation TNF IL4 1692079 1542169 Positive_regulation TNF IL4 1717633 1543701 Positive_regulation TNF IL4 1744584 1545257 Positive_regulation TNF IL4 18475440 1743753 Positive_regulation TNF IL4 18475655 1745169 Positive_regulation TNF IL4 18475657 1745184 Positive_regulation TNF IL4 1911209 431555 Positive_regulation TNF IL4 19901996 1746777 Positive_regulation TNF IL4 19948070 166287 Positive_regulation TNF IL4 2007858 1557282 Positive_regulation TNF IL4 2022925 1557562 Positive_regulation TNF IL4 2039696 434744 Positive_regulation TNF IL4 20544034 2452622 Positive_regulation TNF IL4 20733031 1559598 Positive_regulation TNF IL4 21106069 1621034 Positive_regulation TNF IL4 21267358 742440 Positive_regulation TNF IL4 21799736 2538403 Positive_regulation TNF IL4 21801431 123363 Positive_regulation TNF IL4 21829352 3052609 Positive_regulation TNF IL4 2183871 437489 Positive_regulation TNF IL4 2183871 437547 Positive_regulation TNF IL4 22457616 3055876 Positive_regulation TNF IL4 22570532 1224124 Positive_regulation TNF IL4 2258696 1568178 Positive_regulation TNF IL4 2373990 1572253 Positive_regulation TNF IL4 23835343 727915 Positive_regulation TNF IL4 2406363 1573684 Positive_regulation TNF IL4 24550673 1138205 Positive_regulation TNF IL4 24568275 357525 Positive_regulation TNF IL4 2499653 1576973 Positive_regulation TNF IL4 25111378 2996215 Positive_regulation TNF IL4 25120285 1760422 Positive_regulation TNF IL4 25387665 1050601 Positive_regulation TNF IL4 25387665 1050605 Positive_regulation TNF IL4 2642531 1577550 Positive_regulation TNF IL4 2659724 1577639 Positive_regulation TNF IL4 2677211 1577806 Positive_regulation TNF IL4 2677211 1577818 Positive_regulation TNF IL4 2769183 1577864 Positive_regulation TNF IL4 2785398 442906 Positive_regulation TNF IL4 2833558 1578518 Positive_regulation TNF IL4 3049617 1425444 Positive_regulation TNF IL4 3049617 1425546 Positive_regulation TNF IL4 3049617 1425547 Positive_regulation TNF IL4 3110354 1580037 Positive_regulation TNF IL4 3137305 1580350 Positive_regulation TNF IL4 3143799 1580405 Positive_regulation TNF IL4 3290384 1580771 Positive_regulation TNF IL4 3309124 1580889 Positive_regulation TNF IL4 3309124 1580944 Positive_regulation TNF IL4 3316469 1581004 Positive_regulation TNF IL4 3411293 1581170 Positive_regulation TNF IL4 3435706 443485 Positive_regulation TNF IL4 3491174 1583075 Positive_regulation TNF IL4 3494807 1583223 Positive_regulation TNF IL4 3494807 1583224 Positive_regulation TNF IL4 3494807 1583314 Positive_regulation TNF IL4 3572302 1583453 Positive_regulation TNF IL4 3598461 1583511 Positive_regulation TNF IL4 3819645 1583688 Positive_regulation TNF IL4 8260432 1030855 Positive_regulation TNF IL4 8426121 1595180 Positive_regulation TNF IL4 8478614 1595530 Positive_regulation TNF IL4 9126933 1601099 Positive_regulation TNF IL4 PMC2188223 1605379 Positive_regulation TNF IL5 1586593 426035 Positive_regulation TNF IL5 1643416 702459 Positive_regulation TNF IL5 1692079 1542170 Positive_regulation TNF IL5 1717633 1543702 Positive_regulation TNF IL5 18475440 1743754 Positive_regulation TNF IL5 1911209 431556 Positive_regulation TNF IL5 19901996 1746778 Positive_regulation TNF IL5 19948070 166288 Positive_regulation TNF IL5 2007858 1557283 Positive_regulation TNF IL5 2022925 1557563 Positive_regulation TNF IL5 2039696 434745 Positive_regulation TNF IL5 21267358 742441 Positive_regulation TNF IL5 21801431 123364 Positive_regulation TNF IL5 21829352 3052610 Positive_regulation TNF IL5 2183871 437490 Positive_regulation TNF IL5 2183871 437548 Positive_regulation TNF IL5 22570532 1224125 Positive_regulation TNF IL5 2258696 1568179 Positive_regulation TNF IL5 2373990 1572254 Positive_regulation TNF IL5 2406363 1573685 Positive_regulation TNF IL5 2499653 1576974 Positive_regulation TNF IL5 2642531 1577551 Positive_regulation TNF IL5 2659724 1577640 Positive_regulation TNF IL5 2769183 1577865 Positive_regulation TNF IL5 2785398 442907 Positive_regulation TNF IL5 2833558 1578519 Positive_regulation TNF IL5 3049617 1425445 Positive_regulation TNF IL5 3049617 1425548 Positive_regulation TNF IL5 3049617 1425549 Positive_regulation TNF IL5 3110354 1580038 Positive_regulation TNF IL5 3137305 1580351 Positive_regulation TNF IL5 3143799 1580406 Positive_regulation TNF IL5 3290384 1580772 Positive_regulation TNF IL5 3309124 1580890 Positive_regulation TNF IL5 3309124 1580945 Positive_regulation TNF IL5 3316469 1581005 Positive_regulation TNF IL5 3411293 1581171 Positive_regulation TNF IL5 3435706 443486 Positive_regulation TNF IL5 3491174 1583076 Positive_regulation TNF IL5 3494807 1583225 Positive_regulation TNF IL5 3494807 1583226 Positive_regulation TNF IL5 3494807 1583315 Positive_regulation TNF IL5 3572302 1583454 Positive_regulation TNF IL5 3598461 1583512 Positive_regulation TNF IL5 3819645 1583689 Positive_regulation TNF IL5 8260432 1030856 Positive_regulation TNF IL5 8426121 1595181 Positive_regulation TNF IL5 8478614 1595531 Positive_regulation TNF IL5 PMC2188223 1605380 Positive_regulation TNF IL6 10487610 415295 Positive_regulation TNF IL6 10931794 789726 Positive_regulation TNF IL6 11748361 1632821 Positive_regulation TNF IL6 12417483 791240 Positive_regulation TNF IL6 14651752 3095639 Positive_regulation TNF IL6 15121507 792124 Positive_regulation TNF IL6 15121507 792126 Positive_regulation TNF IL6 1586593 426036 Positive_regulation TNF IL6 16185356 3105684 Positive_regulation TNF IL6 16258194 1740191 Positive_regulation TNF IL6 16259641 395236 Positive_regulation TNF IL6 1643416 702460 Positive_regulation TNF IL6 16642549 3230853 Positive_regulation TNF IL6 16669999 3107216 Positive_regulation TNF IL6 16675414 792630 Positive_regulation TNF IL6 16800873 1722652 Positive_regulation TNF IL6 1692079 1542171 Positive_regulation TNF IL6 17042956 106702 Positive_regulation TNF IL6 1717633 1543703 Positive_regulation TNF IL6 17764562 461018 Positive_regulation TNF IL6 18360651 3176746 Positive_regulation TNF IL6 18410682 110462 Positive_regulation TNF IL6 18472926 1743172 Positive_regulation TNF IL6 18475439 1743535 Positive_regulation TNF IL6 18475440 1743755 Positive_regulation TNF IL6 18475552 1744310 Positive_regulation TNF IL6 18475559 1744326 Positive_regulation TNF IL6 18475591 1744479 Positive_regulation TNF IL6 18475724 1745849 Positive_regulation TNF IL6 18475738 1745975 Positive_regulation TNF IL6 18475748 1746327 Positive_regulation TNF IL6 1911209 431529 Positive_regulation TNF IL6 1911209 431557 Positive_regulation TNF IL6 19148295 1746431 Positive_regulation TNF IL6 19148295 1746434 Positive_regulation TNF IL6 19188427 707836 Positive_regulation TNF IL6 19188427 707864 Positive_regulation TNF IL6 19188427 707892 Positive_regulation TNF IL6 19188427 707894 Positive_regulation TNF IL6 19188427 707940 Positive_regulation TNF IL6 19575800 3109730 Positive_regulation TNF IL6 19672457 1746654 Positive_regulation TNF IL6 19686583 116573 Positive_regulation TNF IL6 19701245 2126398 Positive_regulation TNF IL6 19901996 1746779 Positive_regulation TNF IL6 2007858 1557284 Positive_regulation TNF IL6 20205746 1656114 Positive_regulation TNF IL6 20205746 1656153 Positive_regulation TNF IL6 20205746 1656155 Positive_regulation TNF IL6 20205746 1656158 Positive_regulation TNF IL6 20205746 1656159 Positive_regulation TNF IL6 20224659 1214045 Positive_regulation TNF IL6 2022925 1557564 Positive_regulation TNF IL6 20379419 1623908 Positive_regulation TNF IL6 2039696 434746 Positive_regulation TNF IL6 20482813 118994 Positive_regulation TNF IL6 20550728 659623 Positive_regulation TNF IL6 20699000 257080 Positive_regulation TNF IL6 20808669 1635225 Positive_regulation TNF IL6 20827308 979272 Positive_regulation TNF IL6 20827308 979291 Positive_regulation TNF IL6 21029292 590582 Positive_regulation TNF IL6 21267358 742442 Positive_regulation TNF IL6 21294864 121385 Positive_regulation TNF IL6 21394214 2506821 Positive_regulation TNF IL6 21447195 626984 Positive_regulation TNF IL6 21637744 2525850 Positive_regulation TNF IL6 21637744 2525921 Positive_regulation TNF IL6 21679434 379781 Positive_regulation TNF IL6 21682888 1658616 Positive_regulation TNF IL6 21801431 123365 Positive_regulation TNF IL6 21829352 3052611 Positive_regulation TNF IL6 2183871 437491 Positive_regulation TNF IL6 2183871 437549 Positive_regulation TNF IL6 21845170 1076843 Positive_regulation TNF IL6 21858117 2546377 Positive_regulation TNF IL6 21860543 1749379 Positive_regulation TNF IL6 21966220 3209112 Positive_regulation TNF IL6 21966220 3209113 Positive_regulation TNF IL6 22069489 2569156 Positive_regulation TNF IL6 22069489 2569231 Positive_regulation TNF IL6 22096370 1628395 Positive_regulation TNF IL6 22190977 633854 Positive_regulation TNF IL6 22369693 1661192 Positive_regulation TNF IL6 22417709 125168 Positive_regulation TNF IL6 22506098 1680489 Positive_regulation TNF IL6 22537317 355837 Positive_regulation TNF IL6 22570532 1224126 Positive_regulation TNF IL6 2258696 1568180 Positive_regulation TNF IL6 22615502 1044045 Positive_regulation TNF IL6 22642790 1663030 Positive_regulation TNF IL6 22646809 1728183 Positive_regulation TNF IL6 22654556 678409 Positive_regulation TNF IL6 22654787 875807 Positive_regulation TNF IL6 22679491 2650112 Positive_regulation TNF IL6 22682420 126125 Positive_regulation TNF IL6 22723938 2655174 Positive_regulation TNF IL6 22761629 636596 Positive_regulation TNF IL6 22891067 903447 Positive_regulation TNF IL6 22909087 1626659 Positive_regulation TNF IL6 22911786 2676467 Positive_regulation TNF IL6 22935594 30826 Positive_regulation TNF IL6 23028407 2219738 Positive_regulation TNF IL6 23049531 904427 Positive_regulation TNF IL6 2307935 1569748 Positive_regulation TNF IL6 2307935 1569750 Positive_regulation TNF IL6 23118903 2712087 Positive_regulation TNF IL6 23136554 1060869 Positive_regulation TNF IL6 23185187 95315 Positive_regulation TNF IL6 23236394 2726130 Positive_regulation TNF IL6 23236394 2726166 Positive_regulation TNF IL6 23239116 1239219 Positive_regulation TNF IL6 23281897 409354 Positive_regulation TNF IL6 23285227 2733021 Positive_regulation TNF IL6 23285323 1492776 Positive_regulation TNF IL6 23365595 817122 Positive_regulation TNF IL6 23487396 1620120 Positive_regulation TNF IL6 23510751 3169356 Positive_regulation TNF IL6 23516523 2768220 Positive_regulation TNF IL6 23527096 2769364 Positive_regulation TNF IL6 23531302 1699482 Positive_regulation TNF IL6 23563706 1962725 Positive_regulation TNF IL6 23649808 1405119 Positive_regulation TNF IL6 23675296 3061295 Positive_regulation TNF IL6 23717702 2371922 Positive_regulation TNF IL6 2373990 1572255 Positive_regulation TNF IL6 23788036 563189 Positive_regulation TNF IL6 23812304 2117570 Positive_regulation TNF IL6 23840739 2816269 Positive_regulation TNF IL6 23864770 1754276 Positive_regulation TNF IL6 23901303 1968891 Positive_regulation TNF IL6 23990568 1624259 Positive_regulation TNF IL6 23991101 2840934 Positive_regulation TNF IL6 24040434 2372094 Positive_regulation TNF IL6 2406363 1573686 Positive_regulation TNF IL6 24086143 2350917 Positive_regulation TNF IL6 24098382 2856018 Positive_regulation TNF IL6 24106699 184495 Positive_regulation TNF IL6 24237643 1728470 Positive_regulation TNF IL6 24244348 2879474 Positive_regulation TNF IL6 24244348 2879508 Positive_regulation TNF IL6 24244348 2879541 Positive_regulation TNF IL6 24286116 130162 Positive_regulation TNF IL6 24330807 1667429 Positive_regulation TNF IL6 24348193 3155619 Positive_regulation TNF IL6 24349442 2898074 Positive_regulation TNF IL6 24359092 2236091 Positive_regulation TNF IL6 24381940 186045 Positive_regulation TNF IL6 24426777 1916721 Positive_regulation TNF IL6 24434259 1045746 Positive_regulation TNF IL6 24434316 1045857 Positive_regulation TNF IL6 24471071 3077307 Positive_regulation TNF IL6 24489848 2916472 Positive_regulation TNF IL6 24563869 1495679 Positive_regulation TNF IL6 24624094 964456 Positive_regulation TNF IL6 24642694 2935184 Positive_regulation TNF IL6 24821138 2969090 Positive_regulation TNF IL6 24852285 2972950 Positive_regulation TNF IL6 24885636 273417 Positive_regulation TNF IL6 24932221 1025870 Positive_regulation TNF IL6 24944768 2115571 Positive_regulation TNF IL6 24962480 2118861 Positive_regulation TNF IL6 2499653 1576975 Positive_regulation TNF IL6 2499657 1577008 Positive_regulation TNF IL6 2499657 1577010 Positive_regulation TNF IL6 25019059 948428 Positive_regulation TNF IL6 25104881 1760299 Positive_regulation TNF IL6 25198511 3006084 Positive_regulation TNF IL6 25271853 3011927 Positive_regulation TNF IL6 25289073 845242 Positive_regulation TNF IL6 25478190 412948 Positive_regulation TNF IL6 25506235 1629229 Positive_regulation TNF IL6 25538747 2007479 Positive_regulation TNF IL6 25614712 1763566 Positive_regulation TNF IL6 2642531 1577552 Positive_regulation TNF IL6 2659724 1577641 Positive_regulation TNF IL6 2769183 1577866 Positive_regulation TNF IL6 2783334 1577904 Positive_regulation TNF IL6 2785398 442908 Positive_regulation TNF IL6 2833558 1578520 Positive_regulation TNF IL6 3049617 1425446 Positive_regulation TNF IL6 3049617 1425550 Positive_regulation TNF IL6 3049617 1425551 Positive_regulation TNF IL6 3110354 1580039 Positive_regulation TNF IL6 3137305 1580352 Positive_regulation TNF IL6 3143799 1580407 Positive_regulation TNF IL6 3290384 1580773 Positive_regulation TNF IL6 3309124 1580891 Positive_regulation TNF IL6 3309124 1580946 Positive_regulation TNF IL6 3316469 1581006 Positive_regulation TNF IL6 3411293 1581172 Positive_regulation TNF IL6 3435706 443487 Positive_regulation TNF IL6 3491174 1583077 Positive_regulation TNF IL6 3494807 1583227 Positive_regulation TNF IL6 3494807 1583228 Positive_regulation TNF IL6 3494807 1583316 Positive_regulation TNF IL6 3572302 1583455 Positive_regulation TNF IL6 3598461 1583513 Positive_regulation TNF IL6 3819645 1583690 Positive_regulation TNF IL6 8145042 1594266 Positive_regulation TNF IL6 8163936 1594294 Positive_regulation TNF IL6 8260432 1030857 Positive_regulation TNF IL6 8426121 1595182 Positive_regulation TNF IL6 8478614 1595532 Positive_regulation TNF IL6 8551238 1595903 Positive_regulation TNF IL6 9271590 1601625 Positive_regulation TNF IL6 PMC2188223 1605381 Positive_regulation TNF IL6 PMC3194727 2236106 Positive_regulation TNF IL6ST 20530204 1558452 Positive_regulation TNF IL6ST 22768337 2660831 Positive_regulation TNF IL7 12932290 99930 Positive_regulation TNF IL7 1586593 426037 Positive_regulation TNF IL7 1643416 702461 Positive_regulation TNF IL7 1692079 1542172 Positive_regulation TNF IL7 1717633 1543704 Positive_regulation TNF IL7 17205128 2374261 Positive_regulation TNF IL7 18475440 1743756 Positive_regulation TNF IL7 1911209 431558 Positive_regulation TNF IL7 19884985 1746739 Positive_regulation TNF IL7 19901996 1746780 Positive_regulation TNF IL7 2007858 1557249 Positive_regulation TNF IL7 2007858 1557285 Positive_regulation TNF IL7 2022925 1557565 Positive_regulation TNF IL7 2039696 434747 Positive_regulation TNF IL7 21267358 742443 Positive_regulation TNF IL7 21711548 260366 Positive_regulation TNF IL7 21801431 123366 Positive_regulation TNF IL7 21829352 3052612 Positive_regulation TNF IL7 2183871 437492 Positive_regulation TNF IL7 2183871 437550 Positive_regulation TNF IL7 22570532 1224127 Positive_regulation TNF IL7 2258696 1568181 Positive_regulation TNF IL7 22676399 126103 Positive_regulation TNF IL7 23576878 1628505 Positive_regulation TNF IL7 2373990 1572256 Positive_regulation TNF IL7 2406363 1573687 Positive_regulation TNF IL7 2499653 1576976 Positive_regulation TNF IL7 25061260 1760236 Positive_regulation TNF IL7 25533722 133983 Positive_regulation TNF IL7 2642531 1577553 Positive_regulation TNF IL7 2659724 1577642 Positive_regulation TNF IL7 2769183 1577867 Positive_regulation TNF IL7 2785398 442909 Positive_regulation TNF IL7 2833558 1578521 Positive_regulation TNF IL7 3049617 1425447 Positive_regulation TNF IL7 3049617 1425552 Positive_regulation TNF IL7 3049617 1425553 Positive_regulation TNF IL7 3110354 1580040 Positive_regulation TNF IL7 3137305 1580353 Positive_regulation TNF IL7 3143799 1580408 Positive_regulation TNF IL7 3290384 1580774 Positive_regulation TNF IL7 3309124 1580892 Positive_regulation TNF IL7 3309124 1580947 Positive_regulation TNF IL7 3316469 1581007 Positive_regulation TNF IL7 3411293 1581173 Positive_regulation TNF IL7 3435706 443488 Positive_regulation TNF IL7 3491174 1583078 Positive_regulation TNF IL7 3494807 1583229 Positive_regulation TNF IL7 3494807 1583230 Positive_regulation TNF IL7 3494807 1583317 Positive_regulation TNF IL7 3572302 1583456 Positive_regulation TNF IL7 3598461 1583514 Positive_regulation TNF IL7 3819645 1583691 Positive_regulation TNF IL7 8260432 1030858 Positive_regulation TNF IL7 8426121 1595183 Positive_regulation TNF IL7 8478614 1595533 Positive_regulation TNF IL7 9652754 447276 Positive_regulation TNF IL7 PMC2188223 1605382 Positive_regulation TNF IL8 14651748 3095617 Positive_regulation TNF IL8 15826301 224733 Positive_regulation TNF IL8 1586593 426038 Positive_regulation TNF IL8 16185356 3105685 Positive_regulation TNF IL8 16191192 318559 Positive_regulation TNF IL8 1643416 702462 Positive_regulation TNF IL8 1692079 1542173 Positive_regulation TNF IL8 1717633 1543705 Positive_regulation TNF IL8 18410682 110365 Positive_regulation TNF IL8 18410682 110397 Positive_regulation TNF IL8 18410682 110454 Positive_regulation TNF IL8 18475440 1743757 Positive_regulation TNF IL8 18475483 1743983 Positive_regulation TNF IL8 18475491 1744037 Positive_regulation TNF IL8 18475720 1745583 Positive_regulation TNF IL8 18556683 1035461 Positive_regulation TNF IL8 19014534 2232731 Positive_regulation TNF IL8 1911209 431559 Positive_regulation TNF IL8 19281072 1071642 Positive_regulation TNF IL8 19901996 1746781 Positive_regulation TNF IL8 2007858 1557286 Positive_regulation TNF IL8 20139906 9437 Positive_regulation TNF IL8 20158898 1696598 Positive_regulation TNF IL8 20161853 1043918 Positive_regulation TNF IL8 2022925 1557566 Positive_regulation TNF IL8 2039696 434748 Positive_regulation TNF IL8 20416261 3209778 Positive_regulation TNF IL8 20508788 1710312 Positive_regulation TNF IL8 20877724 2475607 Positive_regulation TNF IL8 21267358 742444 Positive_regulation TNF IL8 21295490 3157823 Positive_regulation TNF IL8 21306632 2233026 Positive_regulation TNF IL8 21423807 2508414 Positive_regulation TNF IL8 21447195 626985 Positive_regulation TNF IL8 21496221 229356 Positive_regulation TNF IL8 21496221 229358 Positive_regulation TNF IL8 21801431 123367 Positive_regulation TNF IL8 21829352 3052613 Positive_regulation TNF IL8 2183871 437493 Positive_regulation TNF IL8 2183871 437551 Positive_regulation TNF IL8 21858117 2546378 Positive_regulation TNF IL8 22069619 3182771 Positive_regulation TNF IL8 22069653 3183319 Positive_regulation TNF IL8 22096348 1628250 Positive_regulation TNF IL8 22235381 1082476 Positive_regulation TNF IL8 22506098 1680490 Positive_regulation TNF IL8 22570532 1224128 Positive_regulation TNF IL8 2258696 1568182 Positive_regulation TNF IL8 22761877 2659057 Positive_regulation TNF IL8 22909087 1626660 Positive_regulation TNF IL8 22924051 636873 Positive_regulation TNF IL8 23065264 1832228 Positive_regulation TNF IL8 23328126 725583 Positive_regulation TNF IL8 23533479 817804 Positive_regulation TNF IL8 23732752 1632242 Positive_regulation TNF IL8 2373990 1572257 Positive_regulation TNF IL8 23800251 1627021 Positive_regulation TNF IL8 23935691 822185 Positive_regulation TNF IL8 23991101 2840935 Positive_regulation TNF IL8 2406363 1573688 Positive_regulation TNF IL8 24212943 499209 Positive_regulation TNF IL8 24385684 1756435 Positive_regulation TNF IL8 24517278 131749 Positive_regulation TNF IL8 24517278 131851 Positive_regulation TNF IL8 24517278 131870 Positive_regulation TNF IL8 24709903 617333 Positive_regulation TNF IL8 24885636 273418 Positive_regulation TNF IL8 2499653 1576977 Positive_regulation TNF IL8 25143751 645506 Positive_regulation TNF IL8 25478190 412949 Positive_regulation TNF IL8 2642531 1577554 Positive_regulation TNF IL8 2659724 1577643 Positive_regulation TNF IL8 2769183 1577868 Positive_regulation TNF IL8 2785398 442910 Positive_regulation TNF IL8 2833558 1578522 Positive_regulation TNF IL8 3049617 1425448 Positive_regulation TNF IL8 3049617 1425554 Positive_regulation TNF IL8 3049617 1425555 Positive_regulation TNF IL8 3110354 1580041 Positive_regulation TNF IL8 3137305 1580354 Positive_regulation TNF IL8 3143799 1580409 Positive_regulation TNF IL8 3260265 1580611 Positive_regulation TNF IL8 3290384 1580775 Positive_regulation TNF IL8 3309124 1580893 Positive_regulation TNF IL8 3309124 1580948 Positive_regulation TNF IL8 3316469 1581008 Positive_regulation TNF IL8 3411293 1581174 Positive_regulation TNF IL8 3435706 443489 Positive_regulation TNF IL8 3491174 1583079 Positive_regulation TNF IL8 3494807 1583231 Positive_regulation TNF IL8 3494807 1583232 Positive_regulation TNF IL8 3494807 1583318 Positive_regulation TNF IL8 3572302 1583457 Positive_regulation TNF IL8 3598461 1583515 Positive_regulation TNF IL8 3819645 1583692 Positive_regulation TNF IL8 8260432 1030859 Positive_regulation TNF IL8 8426121 1595184 Positive_regulation TNF IL8 8478614 1595534 Positive_regulation TNF IL8 PMC2188223 1605383 Positive_regulation TNF IL8 PMC3333060 661030 Positive_regulation TNF IL8 PMC3663404 1731557 Positive_regulation TNF IL9 1586593 426039 Positive_regulation TNF IL9 1643416 702463 Positive_regulation TNF IL9 1692079 1542174 Positive_regulation TNF IL9 1717633 1543706 Positive_regulation TNF IL9 18475440 1743758 Positive_regulation TNF IL9 1911209 431560 Positive_regulation TNF IL9 19901996 1746782 Positive_regulation TNF IL9 2007858 1557287 Positive_regulation TNF IL9 2022925 1557567 Positive_regulation TNF IL9 2039696 434749 Positive_regulation TNF IL9 21267358 742445 Positive_regulation TNF IL9 21801431 123368 Positive_regulation TNF IL9 21829352 3052614 Positive_regulation TNF IL9 2183871 437494 Positive_regulation TNF IL9 2183871 437552 Positive_regulation TNF IL9 22570532 1224129 Positive_regulation TNF IL9 2258696 1568183 Positive_regulation TNF IL9 2373990 1572258 Positive_regulation TNF IL9 2406363 1573689 Positive_regulation TNF IL9 2499653 1576978 Positive_regulation TNF IL9 2642531 1577555 Positive_regulation TNF IL9 2659724 1577644 Positive_regulation TNF IL9 2769183 1577869 Positive_regulation TNF IL9 2785398 442911 Positive_regulation TNF IL9 2833558 1578523 Positive_regulation TNF IL9 3049617 1425449 Positive_regulation TNF IL9 3049617 1425556 Positive_regulation TNF IL9 3049617 1425557 Positive_regulation TNF IL9 3110354 1580042 Positive_regulation TNF IL9 3137305 1580355 Positive_regulation TNF IL9 3143799 1580410 Positive_regulation TNF IL9 3290384 1580776 Positive_regulation TNF IL9 3309124 1580894 Positive_regulation TNF IL9 3309124 1580949 Positive_regulation TNF IL9 3316469 1581009 Positive_regulation TNF IL9 3411293 1581175 Positive_regulation TNF IL9 3435706 443490 Positive_regulation TNF IL9 3491174 1583080 Positive_regulation TNF IL9 3494807 1583233 Positive_regulation TNF IL9 3494807 1583234 Positive_regulation TNF IL9 3494807 1583319 Positive_regulation TNF IL9 3572302 1583458 Positive_regulation TNF IL9 3598461 1583516 Positive_regulation TNF IL9 3819645 1583693 Positive_regulation TNF IL9 8260432 1030860 Positive_regulation TNF IL9 8426121 1595185 Positive_regulation TNF IL9 8478614 1595535 Positive_regulation TNF IL9 PMC2188223 1605384 Positive_regulation TNF INHBA 22313861 3160874 Positive_regulation TNF INHBA 22313861 3160875 Positive_regulation TNF INHBA 22313861 3160901 Positive_regulation TNF INHBA 22313861 3161017 Positive_regulation TNF INHBA 22313861 3161023 Positive_regulation TNF INHBA 22476871 1238664 Positive_regulation TNF INHBA 22476871 1238672 Positive_regulation TNF INS 19188427 707865 Positive_regulation TNF INS 19188427 707895 Positive_regulation TNF INS 21054880 508278 Positive_regulation TNF INS 23383064 2747765 Positive_regulation TNF INS 23437347 2756506 Positive_regulation TNF INS 23811808 733792 Positive_regulation TNF IPO11 22035453 1229750 Positive_regulation TNF IPO13 22035453 1229747 Positive_regulation TNF IPO4 22035453 1229749 Positive_regulation TNF IPO5 22035453 1229751 Positive_regulation TNF IPO7 22035453 1229752 Positive_regulation TNF IPO8 22035453 1229753 Positive_regulation TNF IPO9 22035453 1229748 Positive_regulation TNF IPP 25090613 2995132 Positive_regulation TNF IPP 8996245 1599835 Positive_regulation TNF IRAK1 15804356 3104891 Positive_regulation TNF IRAK1 16606665 1539932 Positive_regulation TNF IRAK1 18759964 111130 Positive_regulation TNF IRAK1 20981241 1748587 Positive_regulation TNF IRAK1 21390243 1049810 Positive_regulation TNF IRAK1 22496647 3056091 Positive_regulation TNF IRAK1 22496647 3056105 Positive_regulation TNF IRAK1 23143987 779381 Positive_regulation TNF IRAK1 23680172 1626978 Positive_regulation TNF IRAK1 24106612 1152205 Positive_regulation TNF IRAK3 20585389 2453856 Positive_regulation TNF IRAK3 20827314 979352 Positive_regulation TNF IRAK3 21390243 1049800 Positive_regulation TNF IRAK4 20981241 1748586 Positive_regulation TNF IRF1 19487420 1554879 Positive_regulation TNF IRF1 21992116 1697924 Positive_regulation TNF IRF1 23514422 1683644 Positive_regulation TNF IRF1 23626590 906833 Positive_regulation TNF IRF1 23807161 441016 Positive_regulation TNF IRF1 24464131 1959713 Positive_regulation TNF IRF1 24464131 1959782 Positive_regulation TNF IRF1 24918037 3115201 Positive_regulation TNF IRF2 23514422 1683645 Positive_regulation TNF IRF3 18617992 3041615 Positive_regulation TNF IRF3 18617992 3041641 Positive_regulation TNF IRF3 18617992 3041642 Positive_regulation TNF IRF3 22916150 2680078 Positive_regulation TNF IRF3 23514422 1683646 Positive_regulation TNF IRF3 23626590 906834 Positive_regulation TNF IRF4 23514422 1683647 Positive_regulation TNF IRF5 23514422 1683648 Positive_regulation TNF IRF6 23514422 1683649 Positive_regulation TNF IRF7 18617992 3041650 Positive_regulation TNF IRF7 19934004 711853 Positive_regulation TNF IRF7 22916150 2680079 Positive_regulation TNF IRF7 23514422 1683650 Positive_regulation TNF IRF7 24455433 3151199 Positive_regulation TNF IRF8 19487420 1554878 Positive_regulation TNF IRF8 23514422 1683643 Positive_regulation TNF IRF9 23514422 1683651 Positive_regulation TNF IRGM 25580435 202402 Positive_regulation TNF IRS1 22234148 1641016 Positive_regulation TNF IRS1 22691241 126142 Positive_regulation TNF IRS1 22919275 1224829 Positive_regulation TNF IRS1 23781214 878820 Positive_regulation TNF IRS1 24386594 86026 Positive_regulation TNF IRS1 25352752 1917493 Positive_regulation TNF ISG15 22879901 2672903 Positive_regulation TNF ISG20 22879901 2672904 Positive_regulation TNF ITGA4 11854362 1522989 Positive_regulation TNF ITGAM 25036109 2990558 Positive_regulation TNF ITGB1 11854362 1522990 Positive_regulation TNF ITIH4 23936448 2830951 Positive_regulation TNF ITIH4 23936448 2830953 Positive_regulation TNF ITIH4 23936448 2830955 Positive_regulation TNF ITIH4 23986795 2220467 Positive_regulation TNF ITIH4 24278714 3150252 Positive_regulation TNF ITIH4 24403874 685028 Positive_regulation TNF ITIH4 24884548 1668090 Positive_regulation TNF ITIH4 24884548 1668093 Positive_regulation TNF ITIH4 25036364 2990695 Positive_regulation TNF JAG1 21637390 1038165 Positive_regulation TNF JAG1 22249448 1566871 Positive_regulation TNF JAG1 22487493 3207574 Positive_regulation TNF JAG2 22190977 633855 Positive_regulation TNF JAG2 23531541 1103840 Positive_regulation TNF JAK1 25400510 1628047 Positive_regulation TNF JAK2 23840548 2815141 Positive_regulation TNF JAK2 25275372 3012022 Positive_regulation TNF JAK2 25400510 1628048 Positive_regulation TNF JAK3 25400510 1628049 Positive_regulation TNF JUN 12110129 99061 Positive_regulation TNF JUN 12110141 99241 Positive_regulation TNF JUN 12361922 791229 Positive_regulation TNF JUN 16606437 658629 Positive_regulation TNF JUN 18341691 3108860 Positive_regulation TNF JUN 18687144 323980 Positive_regulation TNF JUN 19292913 1695984 Positive_regulation TNF JUN 21314908 3209830 Positive_regulation TNF JUN 21755026 1081987 Positive_regulation TNF JUN 22570745 1024139 Positive_regulation TNF JUN 22933572 1807251 Positive_regulation TNF JUN 23002036 724853 Positive_regulation TNF JUN 23002036 724862 Positive_regulation TNF JUN 23034049 3113192 Positive_regulation TNF JUN 23143100 2081896 Positive_regulation TNF JUN 23173923 381109 Positive_regulation TNF JUN 23378729 1915476 Positive_regulation TNF JUN 23554645 1225838 Positive_regulation TNF JUN 23755222 2802104 Positive_regulation TNF JUN 24004852 803470 Positive_regulation TNF JUN 24423080 538854 Positive_regulation TNF JUN 24516606 2921182 Positive_regulation TNF JUN 24523867 2921786 Positive_regulation TNF JUN 24733961 1758138 Positive_regulation TNF JUN 24826069 1917000 Positive_regulation TNF JUN 24842373 1576400 Positive_regulation TNF JUN 25215307 1623224 Positive_regulation TNF JUN 25552899 743684 Positive_regulation TNF JUN PMC2833605 134238 Positive_regulation TNF JUNB 15142264 101168 Positive_regulation TNF JUNB 20221401 2442482 Positive_regulation TNF JUNB 20221401 2442487 Positive_regulation TNF JUND 15142264 101169 Positive_regulation TNF KCNH4 24386331 2903630 Positive_regulation TNF KCNMA1 24129162 1920094 Positive_regulation TNF KCNN4 24885636 273419 Positive_regulation TNF KCNN4 24885636 273463 Positive_regulation TNF KDM5D 25396174 96898 Positive_regulation TNF KDR 16277668 104608 Positive_regulation TNF KHSRP 19570027 137291 Positive_regulation TNF KHSRP 19570027 137475 Positive_regulation TNF KIR3DL1 23659427 509807 Positive_regulation TNF KIT 24206648 367425 Positive_regulation TNF KITLG 21559359 2518416 Positive_regulation TNF KITLG 21559359 2518516 Positive_regulation TNF KL 21593200 719221 Positive_regulation TNF KLF4 24470523 1159226 Positive_regulation TNF KLF5 16500892 2019656 Positive_regulation TNF KLHDC7B 22590687 3221122 Positive_regulation TNF KLHDC7B 25565867 2123744 Positive_regulation TNF KLK3 17178920 1543810 Positive_regulation TNF KLK3 23728723 17878 Positive_regulation TNF KLK3 9927230 1764337 Positive_regulation TNF KLK5 19414552 1554712 Positive_regulation TNF KLK5 19414552 1554718 Positive_regulation TNF KLK5 19414552 1554730 Positive_regulation TNF KLRC1 16507118 104964 Positive_regulation TNF KLRC1 19409079 113162 Positive_regulation TNF KLRC1 21898152 600338 Positive_regulation TNF KLRC1 24098802 2864941 Positive_regulation TNF KLRC1 24516120 1575040 Positive_regulation TNF KLRC1 25132835 913767 Positive_regulation TNF KLRC1 25251060 3010058 Positive_regulation TNF KLRC1 25333972 3018166 Positive_regulation TNF KLRC1 PMC4288483 1623799 Positive_regulation TNF KLRD1 9362537 1602050 Positive_regulation TNF KLRF1 24223577 909857 Positive_regulation TNF KLRG1 22891217 724172 Positive_regulation TNF KRAS 22175014 1686849 Positive_regulation TNF KRAS 22808230 2665191 Positive_regulation TNF KRAS 22908325 1568734 Positive_regulation TNF KRR1 21119000 1783889 Positive_regulation TNF KRR1 23760205 605926 Positive_regulation TNF KRR1 23788031 562993 Positive_regulation TNF KRR1 23788031 563037 Positive_regulation TNF KRR1 24876678 1759074 Positive_regulation TNF KRR1 24932290 2168429 Positive_regulation TNF KRT16 17074928 1543102 Positive_regulation TNF LAG3 12110136 99161 Positive_regulation TNF LAMB1 23024638 925218 Positive_regulation TNF LAMB2 23024638 925219 Positive_regulation TNF LAMB3 23024638 925220 Positive_regulation TNF LAMB4 23024638 925221 Positive_regulation TNF LANCL1 22506098 1680491 Positive_regulation TNF LBH 24278143 2885404 Positive_regulation TNF LBH 25054063 1623609 Positive_regulation TNF LBP 19672466 1670832 Positive_regulation TNF LBP 20046845 1670891 Positive_regulation TNF LBP 20236452 659475 Positive_regulation TNF LBP 23437199 2756173 Positive_regulation TNF LBP 25025695 2989283 Positive_regulation TNF LBP 25025695 2989393 Positive_regulation TNF LBP 25025695 2989395 Positive_regulation TNF LBP 25025695 2989397 Positive_regulation TNF LBP 7504060 1588754 Positive_regulation TNF LBP 9396775 1602312 Positive_regulation TNF LCN2 19390610 2308790 Positive_regulation TNF LCN2 20068130 712451 Positive_regulation TNF LCN2 20068130 712452 Positive_regulation TNF LCN2 20068130 712457 Positive_regulation TNF LCN2 22292925 508873 Positive_regulation TNF LCN2 25326017 1148457 Positive_regulation TNF LCN2 25467539 3147776 Positive_regulation TNF LCT 22039370 1038379 Positive_regulation TNF LCT 22039370 1038394 Positive_regulation TNF LCT 22039370 1038399 Positive_regulation TNF LEO1 1460427 1529594 Positive_regulation TNF LEO1 1460427 1529601 Positive_regulation TNF LEO1 1460427 1529606 Positive_regulation TNF LEO1 1460427 1529611 Positive_regulation TNF LEO1 16172262 1537889 Positive_regulation TNF LEO1 18472926 1743171 Positive_regulation TNF LEO1 19308689 495302 Positive_regulation TNF LEO1 19652714 2422680 Positive_regulation TNF LEO1 21082032 2482396 Positive_regulation TNF LEO1 21860543 1749377 Positive_regulation TNF LEO1 3119758 1580167 Positive_regulation TNF LEO1 7516414 1589298 Positive_regulation TNF LEO1 9836496 1764030 Positive_regulation TNF LEP 16106106 1740062 Positive_regulation TNF LEP 17472433 2369010 Positive_regulation TNF LEP 17472433 2369012 Positive_regulation TNF LEP 19888448 2430224 Positive_regulation TNF LEP 19888448 2430225 Positive_regulation TNF LEP 19902023 1489561 Positive_regulation TNF LEP 20607056 1681552 Positive_regulation TNF LEP 20607056 1681558 Positive_regulation TNF LEP 21243519 1491460 Positive_regulation TNF LEP 21243519 1491465 Positive_regulation TNF LEP 21243519 1491586 Positive_regulation TNF LEP 21655142 1075790 Positive_regulation TNF LEP 21779146 731305 Positive_regulation TNF LEP 21960997 980042 Positive_regulation TNF LEP 22125453 3152126 Positive_regulation TNF LEP 22313574 1724433 Positive_regulation TNF LEP 22911724 2675988 Positive_regulation TNF LEP 22973876 357276 Positive_regulation TNF LEP 23343052 1036492 Positive_regulation TNF LEP 23343052 1036493 Positive_regulation TNF LEP 23343052 1036499 Positive_regulation TNF LEP 23431245 1751611 Positive_regulation TNF LEP 23593289 2780587 Positive_regulation TNF LEP 23691290 1669961 Positive_regulation TNF LEP 24098530 2858089 Positive_regulation TNF LEP 24455420 1152549 Positive_regulation TNF LEP 24533162 2922415 Positive_regulation TNF LEP 24533162 2922418 Positive_regulation TNF LEP 24533162 2922419 Positive_regulation TNF LEP 24533162 2922422 Positive_regulation TNF LEP 24533162 2922423 Positive_regulation TNF LEP 24533162 2922424 Positive_regulation TNF LEP 24757680 189539 Positive_regulation TNF LEP 24799765 1758378 Positive_regulation TNF LEP 25047119 2990877 Positive_regulation TNF LEP 25047119 2990878 Positive_regulation TNF LEP 25047119 2990879 Positive_regulation TNF LEP 25047119 2990889 Positive_regulation TNF LEP 25047119 2990891 Positive_regulation TNF LEP 25125800 1760476 Positive_regulation TNF LEP 25343030 848169 Positive_regulation TNF LGALS3 21765917 2536249 Positive_regulation TNF LGALS3 24367694 2900596 Positive_regulation TNF LGALS3 24995007 913214 Positive_regulation TNF LGALS9 20209097 2442261 Positive_regulation TNF LGALS9 22952413 1628450 Positive_regulation TNF LGALS9 25375372 578814 Positive_regulation TNF LIF 21637744 2525851 Positive_regulation TNF LIF 21637744 2525922 Positive_regulation TNF LIF 23236394 2726167 Positive_regulation TNF LIF 23236394 2726168 Positive_regulation TNF LIF 24008729 565083 Positive_regulation TNF LIG1 15265236 390082 Positive_regulation TNF LIG3 15265236 390083 Positive_regulation TNF LIG4 15265236 390084 Positive_regulation TNF LILRB1 25203514 3006378 Positive_regulation TNF LIN37 25368492 1636240 Positive_regulation TNF LIN52 25368492 1636237 Positive_regulation TNF LIN54 25368492 1636238 Positive_regulation TNF LIN9 25368492 1636239 Positive_regulation TNF LITAF 21633715 1912780 Positive_regulation TNF LITAF 21984950 2561249 Positive_regulation TNF LITAF 21984950 2561252 Positive_regulation TNF LITAF 21984950 2561254 Positive_regulation TNF LITAF 21984950 2561255 Positive_regulation TNF LMO7 23587438 1666161 Positive_regulation TNF LMO7 23587438 1666561 Positive_regulation TNF LPA 16322770 3039071 Positive_regulation TNF LPA 20846396 353596 Positive_regulation TNF LPA 23024745 2689661 Positive_regulation TNF LPA 23139770 2713900 Positive_regulation TNF LPA 23549288 3134676 Positive_regulation TNF LPAR1 25356505 1132678 Positive_regulation TNF LPCAT3 23481064 1045259 Positive_regulation TNF LPIN2 24359092 2236090 Positive_regulation TNF LPL 22473401 653204 Positive_regulation TNF LPL 22682420 126126 Positive_regulation TNF LPL 24160467 364218 Positive_regulation TNF LRG1 25246736 1636203 Positive_regulation TNF LTA 10075974 1511208 Positive_regulation TNF LTA 11157059 1518418 Positive_regulation TNF LTA 12070290 1523641 Positive_regulation TNF LTA 12070290 1523642 Positive_regulation TNF LTA 18195076 1548705 Positive_regulation TNF LTA 23006534 1698878 Positive_regulation TNF LTA 23031213 3113150 Positive_regulation TNF LTA 23060884 904637 Positive_regulation TNF LTA 23826682 3210526 Positive_regulation TNF LTA 24069456 2853351 Positive_regulation TNF LTA 24171786 1627700 Positive_regulation TNF LTA 24288685 185459 Positive_regulation TNF LTA 24349012 2896568 Positive_regulation TNF LTA 24349012 2896599 Positive_regulation TNF LTA 24349012 2896600 Positive_regulation TNF LTA 24453421 1756803 Positive_regulation TNF LTA 24600193 2248343 Positive_regulation TNF LTA 25057505 1622503 Positive_regulation TNF LTA 25078879 660737 Positive_regulation TNF LTA 3279996 443321 Positive_regulation TNF LTA 3435705 443382 Positive_regulation TNF LTA 3435705 443383 Positive_regulation TNF LTA 3435705 443384 Positive_regulation TNF LTA 3435705 443385 Positive_regulation TNF LTA 3435705 443386 Positive_regulation TNF LTA 3435705 443387 Positive_regulation TNF LTA 3435705 443388 Positive_regulation TNF LTA 3435705 443389 Positive_regulation TNF LTA 3435705 443390 Positive_regulation TNF LTA 3435705 443391 Positive_regulation TNF LTA 3435705 443392 Positive_regulation TNF LTA 3435705 443393 Positive_regulation TNF LTA 3435705 443395 Positive_regulation TNF LTA 3435705 443396 Positive_regulation TNF LTA 3435705 443399 Positive_regulation TNF LTA 3435705 443400 Positive_regulation TNF LTA 3888244 443551 Positive_regulation TNF LTA 3888244 443552 Positive_regulation TNF LTA 3888244 443553 Positive_regulation TNF LTA 3888244 443554 Positive_regulation TNF LTB 1460427 1529612 Positive_regulation TNF LTB 18472956 1743391 Positive_regulation TNF LTB 18472956 1743399 Positive_regulation TNF LTB 22577251 1749932 Positive_regulation TNF LTB 24473164 1730538 Positive_regulation TNF LTB 24913232 1576594 Positive_regulation TNF LTB 7525604 1436341 Positive_regulation TNF LTF 22708778 355998 Positive_regulation TNF LTF 23547923 1725721 Positive_regulation TNF LTF PMC3495428 661108 Positive_regulation TNF LY6G6D 24911653 152866 Positive_regulation TNF LY75 15743491 102689 Positive_regulation TNF LY86 15743491 102687 Positive_regulation TNF LY9 15743491 102690 Positive_regulation TNF LY96 15743491 102688 Positive_regulation TNF LY96 24165011 3123877 Positive_regulation TNF LYN 24474940 963446 Positive_regulation TNF LYZ 18475501 1744090 Positive_regulation TNF MAA 15826301 224726 Positive_regulation TNF MAA 15826301 224727 Positive_regulation TNF MAA 15826301 224728 Positive_regulation TNF MAA 15826301 224730 Positive_regulation TNF MAA 15826301 224731 Positive_regulation TNF MAA 15826301 224732 Positive_regulation TNF MADCAM1 11481030 312654 Positive_regulation TNF MADCAM1 12625840 312748 Positive_regulation TNF MADCAM1 17868448 392094 Positive_regulation TNF MADCAM1 17868448 392106 Positive_regulation TNF MADCAM1 17868448 392107 Positive_regulation TNF MADCAM1 21373262 1490002 Positive_regulation TNF MAGI1 12061424 1738141 Positive_regulation TNF MAGT1 23437404 2756824 Positive_regulation TNF MAL 22701453 901649 Positive_regulation TNF MALT1 16432253 1539469 Positive_regulation TNF MALT1 23922952 2827749 Positive_regulation TNF MAP2K1 15699069 1534474 Positive_regulation TNF MAP2K1 22069638 3182918 Positive_regulation TNF MAP2K1 22455317 3210184 Positive_regulation TNF MAP2K1 23878744 1150831 Positive_regulation TNF MAP2K1 9529323 1602588 Positive_regulation TNF MAP2K2 15699069 1534475 Positive_regulation TNF MAP2K3 15699069 1534476 Positive_regulation TNF MAP2K3 24349164 2896894 Positive_regulation TNF MAP2K4 15699069 1534477 Positive_regulation TNF MAP2K5 15699069 1534478 Positive_regulation TNF MAP2K6 15699069 1534479 Positive_regulation TNF MAP2K7 15699069 1534480 Positive_regulation TNF MAP3K11 19918265 609836 Positive_regulation TNF MAP3K11 19918265 609867 Positive_regulation TNF MAP3K11 19918265 609900 Positive_regulation TNF MAP3K11 19918265 609929 Positive_regulation TNF MAP3K11 21194439 1657667 Positive_regulation TNF MAP3K5 19389260 525258 Positive_regulation TNF MAP3K5 21119000 1783890 Positive_regulation TNF MAP3K5 22654913 1068287 Positive_regulation TNF MAP3K5 22719792 814727 Positive_regulation TNF MAP3K5 24723994 2228581 Positive_regulation TNF MAP3K7 16987412 384042 Positive_regulation TNF MAP3K7 19307598 1364681 Positive_regulation TNF MAP3K7 19307598 1364683 Positive_regulation TNF MAP3K7 22313861 3160902 Positive_regulation TNF MAP3K7 22313861 3160944 Positive_regulation TNF MAP3K7 23056924 139793 Positive_regulation TNF MAP3K7 23331383 1675464 Positive_regulation TNF MAP3K7 24386633 186126 Positive_regulation TNF MAP3K7 24911653 152868 Positive_regulation TNF MAP3K8 12486099 1525580 Positive_regulation TNF MAP3K8 15575964 1844342 Positive_regulation TNF MAP3K8 15575964 1844350 Positive_regulation TNF MAP3K8 15575964 1844351 Positive_regulation TNF MAP3K8 15699069 1534481 Positive_regulation TNF MAP3K8 19808894 711197 Positive_regulation TNF MAP3K8 23557442 151362 Positive_regulation TNF MAP3K8 23557442 151373 Positive_regulation TNF MAP3K8 23557442 151374 Positive_regulation TNF MAP3K8 24642963 2935457 Positive_regulation TNF MAP4K4 18671879 323966 Positive_regulation TNF MAPK1 11015442 1517366 Positive_regulation TNF MAPK1 11015442 1517405 Positive_regulation TNF MAPK1 11781369 1522163 Positive_regulation TNF MAPK1 12110137 99171 Positive_regulation TNF MAPK1 14960183 656418 Positive_regulation TNF MAPK1 16207331 104296 Positive_regulation TNF MAPK1 16542479 105134 Positive_regulation TNF MAPK1 16581537 792534 Positive_regulation TNF MAPK1 16581537 792562 Positive_regulation TNF MAPK1 16581537 792588 Positive_regulation TNF MAPK1 16581537 792614 Positive_regulation TNF MAPK1 16606437 658649 Positive_regulation TNF MAPK1 18036262 1655163 Positive_regulation TNF MAPK1 18410682 110398 Positive_regulation TNF MAPK1 18478117 2388660 Positive_regulation TNF MAPK1 19052649 1908507 Positive_regulation TNF MAPK1 19052649 1908546 Positive_regulation TNF MAPK1 19893201 736345 Positive_regulation TNF MAPK1 20089176 284007 Positive_regulation TNF MAPK1 20157567 26178 Positive_regulation TNF MAPK1 20157567 26431 Positive_regulation TNF MAPK1 20615213 119567 Positive_regulation TNF MAPK1 20644550 10404 Positive_regulation TNF MAPK1 20844314 27758 Positive_regulation TNF MAPK1 20844314 28220 Positive_regulation TNF MAPK1 20939898 353646 Positive_regulation TNF MAPK1 21317295 717857 Positive_regulation TNF MAPK1 21485745 734875 Positive_regulation TNF MAPK1 21547253 1748951 Positive_regulation TNF MAPK1 21682898 122921 Positive_regulation TNF MAPK1 21961050 2224116 Positive_regulation TNF MAPK1 22069563 3181868 Positive_regulation TNF MAPK1 22315682 1687059 Positive_regulation TNF MAPK1 22455317 3210185 Positive_regulation TNF MAPK1 22524232 1661889 Positive_regulation TNF MAPK1 22611435 814304 Positive_regulation TNF MAPK1 22723938 2655175 Positive_regulation TNF MAPK1 22848503 2669180 Positive_regulation TNF MAPK1 23209344 1750768 Positive_regulation TNF MAPK1 23282009 1665863 Positive_regulation TNF MAPK1 23326086 1162761 Positive_regulation TNF MAPK1 23331383 1675465 Positive_regulation TNF MAPK1 23533994 180641 Positive_regulation TNF MAPK1 23549267 1104801 Positive_regulation TNF MAPK1 23549267 1104955 Positive_regulation TNF MAPK1 23549267 1105017 Positive_regulation TNF MAPK1 23549267 1105255 Positive_regulation TNF MAPK1 23557259 3215461 Positive_regulation TNF MAPK1 23557259 3215503 Positive_regulation TNF MAPK1 23587438 1666538 Positive_regulation TNF MAPK1 23587438 1666554 Positive_regulation TNF MAPK1 23587438 1666562 Positive_regulation TNF MAPK1 23755184 2801821 Positive_regulation TNF MAPK1 23799152 2807414 Positive_regulation TNF MAPK1 23908766 749694 Positive_regulation TNF MAPK1 23936634 140766 Positive_regulation TNF MAPK1 23967215 2834968 Positive_regulation TNF MAPK1 24008729 565084 Positive_regulation TNF MAPK1 24024042 2003194 Positive_regulation TNF MAPK1 24039713 2844608 Positive_regulation TNF MAPK1 24065916 973392 Positive_regulation TNF MAPK1 24101950 2227276 Positive_regulation TNF MAPK1 24307884 3155509 Positive_regulation TNF MAPK1 24376635 2901597 Positive_regulation TNF MAPK1 24377382 3225629 Positive_regulation TNF MAPK1 24381514 3155631 Positive_regulation TNF MAPK1 24421891 2909265 Positive_regulation TNF MAPK1 24423080 538855 Positive_regulation TNF MAPK1 24530567 1621204 Positive_regulation TNF MAPK1 24629023 1701463 Positive_regulation TNF MAPK1 24707477 188418 Positive_regulation TNF MAPK1 24722253 2951092 Positive_regulation TNF MAPK1 24747164 18892 Positive_regulation TNF MAPK1 24886088 347452 Positive_regulation TNF MAPK1 25025559 1162099 Positive_regulation TNF MAPK1 25025559 1162173 Positive_regulation TNF MAPK1 25180066 2229990 Positive_regulation TNF MAPK1 25435878 1074915 Positive_regulation TNF MAPK1 25606044 746877 Positive_regulation TNF MAPK1 8666946 1597639 Positive_regulation TNF MAPK10 11015442 1517367 Positive_regulation TNF MAPK10 11015442 1517406 Positive_regulation TNF MAPK10 11781369 1522164 Positive_regulation TNF MAPK10 12110137 99172 Positive_regulation TNF MAPK10 14960183 656419 Positive_regulation TNF MAPK10 16207331 104297 Positive_regulation TNF MAPK10 16542479 105135 Positive_regulation TNF MAPK10 16581537 792535 Positive_regulation TNF MAPK10 16581537 792563 Positive_regulation TNF MAPK10 16581537 792589 Positive_regulation TNF MAPK10 16581537 792615 Positive_regulation TNF MAPK10 16606437 658650 Positive_regulation TNF MAPK10 18410682 110399 Positive_regulation TNF MAPK10 18478117 2388661 Positive_regulation TNF MAPK10 19052649 1908508 Positive_regulation TNF MAPK10 19052649 1908547 Positive_regulation TNF MAPK10 19893201 736346 Positive_regulation TNF MAPK10 20089176 284008 Positive_regulation TNF MAPK10 20157567 26179 Positive_regulation TNF MAPK10 20157567 26432 Positive_regulation TNF MAPK10 20615213 119568 Positive_regulation TNF MAPK10 20644550 10405 Positive_regulation TNF MAPK10 20844314 27759 Positive_regulation TNF MAPK10 20844314 28221 Positive_regulation TNF MAPK10 20939898 353647 Positive_regulation TNF MAPK10 21317295 717858 Positive_regulation TNF MAPK10 21485745 734876 Positive_regulation TNF MAPK10 21547253 1748952 Positive_regulation TNF MAPK10 21682898 122922 Positive_regulation TNF MAPK10 21961050 2224117 Positive_regulation TNF MAPK10 22069563 3181869 Positive_regulation TNF MAPK10 22315682 1687060 Positive_regulation TNF MAPK10 22455317 3210186 Positive_regulation TNF MAPK10 22524232 1661890 Positive_regulation TNF MAPK10 22611435 814305 Positive_regulation TNF MAPK10 22723938 2655176 Positive_regulation TNF MAPK10 22848503 2669181 Positive_regulation TNF MAPK10 23282009 1665864 Positive_regulation TNF MAPK10 23326086 1162762 Positive_regulation TNF MAPK10 23331383 1675466 Positive_regulation TNF MAPK10 23533994 180642 Positive_regulation TNF MAPK10 23549267 1104802 Positive_regulation TNF MAPK10 23549267 1104956 Positive_regulation TNF MAPK10 23549267 1105018 Positive_regulation TNF MAPK10 23549267 1105256 Positive_regulation TNF MAPK10 23557259 3215462 Positive_regulation TNF MAPK10 23557259 3215504 Positive_regulation TNF MAPK10 23755184 2801822 Positive_regulation TNF MAPK10 23799152 2807415 Positive_regulation TNF MAPK10 23908766 749695 Positive_regulation TNF MAPK10 23936634 140767 Positive_regulation TNF MAPK10 23967215 2834969 Positive_regulation TNF MAPK10 24008729 565085 Positive_regulation TNF MAPK10 24024042 2003195 Positive_regulation TNF MAPK10 24065916 973393 Positive_regulation TNF MAPK10 24101950 2227277 Positive_regulation TNF MAPK10 24307884 3155510 Positive_regulation TNF MAPK10 24376635 2901598 Positive_regulation TNF MAPK10 24377382 3225630 Positive_regulation TNF MAPK10 24381514 3155632 Positive_regulation TNF MAPK10 24421891 2909266 Positive_regulation TNF MAPK10 24423080 538856 Positive_regulation TNF MAPK10 24530567 1621205 Positive_regulation TNF MAPK10 24629023 1701464 Positive_regulation TNF MAPK10 24707477 188419 Positive_regulation TNF MAPK10 24747164 18893 Positive_regulation TNF MAPK10 24886088 347453 Positive_regulation TNF MAPK10 25025559 1162100 Positive_regulation TNF MAPK10 25025559 1162174 Positive_regulation TNF MAPK10 25180066 2229991 Positive_regulation TNF MAPK10 25435878 1074916 Positive_regulation TNF MAPK10 25606044 746878 Positive_regulation TNF MAPK10 8666946 1597640 Positive_regulation TNF MAPK11 11015442 1517368 Positive_regulation TNF MAPK11 11015442 1517407 Positive_regulation TNF MAPK11 11781369 1522165 Positive_regulation TNF MAPK11 12110137 99173 Positive_regulation TNF MAPK11 14960183 656420 Positive_regulation TNF MAPK11 16207331 104298 Positive_regulation TNF MAPK11 16542479 105136 Positive_regulation TNF MAPK11 16581537 792536 Positive_regulation TNF MAPK11 16581537 792564 Positive_regulation TNF MAPK11 16581537 792590 Positive_regulation TNF MAPK11 16581537 792616 Positive_regulation TNF MAPK11 16606437 658651 Positive_regulation TNF MAPK11 18410682 110400 Positive_regulation TNF MAPK11 18478117 2388662 Positive_regulation TNF MAPK11 19052649 1908509 Positive_regulation TNF MAPK11 19052649 1908548 Positive_regulation TNF MAPK11 19893201 736347 Positive_regulation TNF MAPK11 20089176 284009 Positive_regulation TNF MAPK11 20157567 26180 Positive_regulation TNF MAPK11 20157567 26433 Positive_regulation TNF MAPK11 20615213 119569 Positive_regulation TNF MAPK11 20644550 10406 Positive_regulation TNF MAPK11 20844314 27760 Positive_regulation TNF MAPK11 20844314 28222 Positive_regulation TNF MAPK11 20939898 353648 Positive_regulation TNF MAPK11 21317295 717859 Positive_regulation TNF MAPK11 21485745 734877 Positive_regulation TNF MAPK11 21547253 1748953 Positive_regulation TNF MAPK11 21682898 122923 Positive_regulation TNF MAPK11 21961050 2224118 Positive_regulation TNF MAPK11 22069563 3181870 Positive_regulation TNF MAPK11 22315682 1687061 Positive_regulation TNF MAPK11 22455317 3210187 Positive_regulation TNF MAPK11 22524232 1661891 Positive_regulation TNF MAPK11 22611435 814306 Positive_regulation TNF MAPK11 22723938 2655177 Positive_regulation TNF MAPK11 22848503 2669182 Positive_regulation TNF MAPK11 23282009 1665865 Positive_regulation TNF MAPK11 23326086 1162763 Positive_regulation TNF MAPK11 23331383 1675467 Positive_regulation TNF MAPK11 23533994 180643 Positive_regulation TNF MAPK11 23549267 1104803 Positive_regulation TNF MAPK11 23549267 1104957 Positive_regulation TNF MAPK11 23549267 1105019 Positive_regulation TNF MAPK11 23549267 1105257 Positive_regulation TNF MAPK11 23557259 3215463 Positive_regulation TNF MAPK11 23557259 3215505 Positive_regulation TNF MAPK11 23755184 2801823 Positive_regulation TNF MAPK11 23799152 2807416 Positive_regulation TNF MAPK11 23908766 749696 Positive_regulation TNF MAPK11 23936634 140768 Positive_regulation TNF MAPK11 23967215 2834970 Positive_regulation TNF MAPK11 24008729 565086 Positive_regulation TNF MAPK11 24024042 2003196 Positive_regulation TNF MAPK11 24065916 973394 Positive_regulation TNF MAPK11 24101950 2227278 Positive_regulation TNF MAPK11 24307884 3155511 Positive_regulation TNF MAPK11 24376635 2901599 Positive_regulation TNF MAPK11 24377382 3225631 Positive_regulation TNF MAPK11 24381514 3155633 Positive_regulation TNF MAPK11 24421891 2909267 Positive_regulation TNF MAPK11 24423080 538857 Positive_regulation TNF MAPK11 24530567 1621206 Positive_regulation TNF MAPK11 24629023 1701465 Positive_regulation TNF MAPK11 24707477 188420 Positive_regulation TNF MAPK11 24747164 18894 Positive_regulation TNF MAPK11 24886088 347454 Positive_regulation TNF MAPK11 25025559 1162101 Positive_regulation TNF MAPK11 25025559 1162175 Positive_regulation TNF MAPK11 25180066 2229992 Positive_regulation TNF MAPK11 25435878 1074917 Positive_regulation TNF MAPK11 25606044 746879 Positive_regulation TNF MAPK11 8666946 1597641 Positive_regulation TNF MAPK12 11015442 1517369 Positive_regulation TNF MAPK12 11015442 1517408 Positive_regulation TNF MAPK12 11781369 1522166 Positive_regulation TNF MAPK12 12110137 99174 Positive_regulation TNF MAPK12 14960183 656421 Positive_regulation TNF MAPK12 16207331 104299 Positive_regulation TNF MAPK12 16542479 105137 Positive_regulation TNF MAPK12 16581537 792537 Positive_regulation TNF MAPK12 16581537 792565 Positive_regulation TNF MAPK12 16581537 792591 Positive_regulation TNF MAPK12 16581537 792617 Positive_regulation TNF MAPK12 16606437 658652 Positive_regulation TNF MAPK12 18410682 110401 Positive_regulation TNF MAPK12 18478117 2388663 Positive_regulation TNF MAPK12 19052649 1908510 Positive_regulation TNF MAPK12 19052649 1908549 Positive_regulation TNF MAPK12 19893201 736348 Positive_regulation TNF MAPK12 20089176 284010 Positive_regulation TNF MAPK12 20157567 26181 Positive_regulation TNF MAPK12 20157567 26434 Positive_regulation TNF MAPK12 20615213 119570 Positive_regulation TNF MAPK12 20644550 10407 Positive_regulation TNF MAPK12 20844314 27761 Positive_regulation TNF MAPK12 20844314 28223 Positive_regulation TNF MAPK12 20939898 353649 Positive_regulation TNF MAPK12 21317295 717860 Positive_regulation TNF MAPK12 21485745 734878 Positive_regulation TNF MAPK12 21547253 1748954 Positive_regulation TNF MAPK12 21682898 122924 Positive_regulation TNF MAPK12 21961050 2224119 Positive_regulation TNF MAPK12 22069563 3181871 Positive_regulation TNF MAPK12 22315682 1687062 Positive_regulation TNF MAPK12 22455317 3210188 Positive_regulation TNF MAPK12 22524232 1661892 Positive_regulation TNF MAPK12 22611435 814307 Positive_regulation TNF MAPK12 22723938 2655178 Positive_regulation TNF MAPK12 22848503 2669183 Positive_regulation TNF MAPK12 23282009 1665866 Positive_regulation TNF MAPK12 23326086 1162764 Positive_regulation TNF MAPK12 23331383 1675468 Positive_regulation TNF MAPK12 23533994 180644 Positive_regulation TNF MAPK12 23549267 1104804 Positive_regulation TNF MAPK12 23549267 1104958 Positive_regulation TNF MAPK12 23549267 1105020 Positive_regulation TNF MAPK12 23549267 1105258 Positive_regulation TNF MAPK12 23557259 3215464 Positive_regulation TNF MAPK12 23557259 3215506 Positive_regulation TNF MAPK12 23755184 2801824 Positive_regulation TNF MAPK12 23799152 2807417 Positive_regulation TNF MAPK12 23908766 749697 Positive_regulation TNF MAPK12 23936634 140769 Positive_regulation TNF MAPK12 23967215 2834971 Positive_regulation TNF MAPK12 24008729 565087 Positive_regulation TNF MAPK12 24024042 2003197 Positive_regulation TNF MAPK12 24065916 973395 Positive_regulation TNF MAPK12 24101950 2227279 Positive_regulation TNF MAPK12 24307884 3155512 Positive_regulation TNF MAPK12 24376635 2901600 Positive_regulation TNF MAPK12 24377382 3225632 Positive_regulation TNF MAPK12 24381514 3155634 Positive_regulation TNF MAPK12 24421891 2909268 Positive_regulation TNF MAPK12 24423080 538858 Positive_regulation TNF MAPK12 24530567 1621207 Positive_regulation TNF MAPK12 24629023 1701466 Positive_regulation TNF MAPK12 24707477 188421 Positive_regulation TNF MAPK12 24747164 18895 Positive_regulation TNF MAPK12 24886088 347455 Positive_regulation TNF MAPK12 25025559 1162102 Positive_regulation TNF MAPK12 25025559 1162176 Positive_regulation TNF MAPK12 25180066 2229993 Positive_regulation TNF MAPK12 25435878 1074918 Positive_regulation TNF MAPK12 25606044 746880 Positive_regulation TNF MAPK12 8666946 1597642 Positive_regulation TNF MAPK13 11015442 1517370 Positive_regulation TNF MAPK13 11015442 1517409 Positive_regulation TNF MAPK13 11781369 1522167 Positive_regulation TNF MAPK13 12110137 99175 Positive_regulation TNF MAPK13 14960183 656422 Positive_regulation TNF MAPK13 16207331 104300 Positive_regulation TNF MAPK13 16542479 105138 Positive_regulation TNF MAPK13 16581537 792538 Positive_regulation TNF MAPK13 16581537 792566 Positive_regulation TNF MAPK13 16581537 792592 Positive_regulation TNF MAPK13 16581537 792618 Positive_regulation TNF MAPK13 16606437 658653 Positive_regulation TNF MAPK13 18410682 110402 Positive_regulation TNF MAPK13 18478117 2388664 Positive_regulation TNF MAPK13 19052649 1908511 Positive_regulation TNF MAPK13 19052649 1908550 Positive_regulation TNF MAPK13 19893201 736349 Positive_regulation TNF MAPK13 20089176 284011 Positive_regulation TNF MAPK13 20157567 26182 Positive_regulation TNF MAPK13 20157567 26435 Positive_regulation TNF MAPK13 20615213 119571 Positive_regulation TNF MAPK13 20644550 10408 Positive_regulation TNF MAPK13 20844314 27762 Positive_regulation TNF MAPK13 20844314 28224 Positive_regulation TNF MAPK13 20939898 353650 Positive_regulation TNF MAPK13 21317295 717861 Positive_regulation TNF MAPK13 21485745 734879 Positive_regulation TNF MAPK13 21547253 1748955 Positive_regulation TNF MAPK13 21682898 122925 Positive_regulation TNF MAPK13 21961050 2224120 Positive_regulation TNF MAPK13 22069563 3181872 Positive_regulation TNF MAPK13 22315682 1687063 Positive_regulation TNF MAPK13 22455317 3210189 Positive_regulation TNF MAPK13 22524232 1661893 Positive_regulation TNF MAPK13 22611435 814308 Positive_regulation TNF MAPK13 22723938 2655179 Positive_regulation TNF MAPK13 22848503 2669184 Positive_regulation TNF MAPK13 23282009 1665867 Positive_regulation TNF MAPK13 23326086 1162765 Positive_regulation TNF MAPK13 23331383 1675469 Positive_regulation TNF MAPK13 23533994 180645 Positive_regulation TNF MAPK13 23549267 1104805 Positive_regulation TNF MAPK13 23549267 1104959 Positive_regulation TNF MAPK13 23549267 1105021 Positive_regulation TNF MAPK13 23549267 1105259 Positive_regulation TNF MAPK13 23557259 3215465 Positive_regulation TNF MAPK13 23557259 3215507 Positive_regulation TNF MAPK13 23755184 2801825 Positive_regulation TNF MAPK13 23799152 2807418 Positive_regulation TNF MAPK13 23908766 749698 Positive_regulation TNF MAPK13 23936634 140770 Positive_regulation TNF MAPK13 23967215 2834972 Positive_regulation TNF MAPK13 24008729 565088 Positive_regulation TNF MAPK13 24024042 2003198 Positive_regulation TNF MAPK13 24065916 973396 Positive_regulation TNF MAPK13 24101950 2227280 Positive_regulation TNF MAPK13 24307884 3155513 Positive_regulation TNF MAPK13 24376635 2901601 Positive_regulation TNF MAPK13 24377382 3225633 Positive_regulation TNF MAPK13 24381514 3155635 Positive_regulation TNF MAPK13 24421891 2909269 Positive_regulation TNF MAPK13 24423080 538859 Positive_regulation TNF MAPK13 24530567 1621208 Positive_regulation TNF MAPK13 24629023 1701467 Positive_regulation TNF MAPK13 24707477 188422 Positive_regulation TNF MAPK13 24747164 18896 Positive_regulation TNF MAPK13 24886088 347456 Positive_regulation TNF MAPK13 25025559 1162103 Positive_regulation TNF MAPK13 25025559 1162177 Positive_regulation TNF MAPK13 25180066 2229994 Positive_regulation TNF MAPK13 25435878 1074919 Positive_regulation TNF MAPK13 25606044 746881 Positive_regulation TNF MAPK13 8666946 1597643 Positive_regulation TNF MAPK14 11015442 1517371 Positive_regulation TNF MAPK14 11015442 1517410 Positive_regulation TNF MAPK14 11781369 1522168 Positive_regulation TNF MAPK14 12110137 99176 Positive_regulation TNF MAPK14 14960183 656423 Positive_regulation TNF MAPK14 16207331 104301 Positive_regulation TNF MAPK14 16542479 105139 Positive_regulation TNF MAPK14 16581537 792539 Positive_regulation TNF MAPK14 16581537 792567 Positive_regulation TNF MAPK14 16581537 792593 Positive_regulation TNF MAPK14 16581537 792619 Positive_regulation TNF MAPK14 16606437 658654 Positive_regulation TNF MAPK14 18410682 110403 Positive_regulation TNF MAPK14 18478117 2388665 Positive_regulation TNF MAPK14 19052649 1908512 Positive_regulation TNF MAPK14 19052649 1908551 Positive_regulation TNF MAPK14 19893201 736350 Positive_regulation TNF MAPK14 20089176 284012 Positive_regulation TNF MAPK14 20157567 26183 Positive_regulation TNF MAPK14 20157567 26436 Positive_regulation TNF MAPK14 20615213 119572 Positive_regulation TNF MAPK14 20644550 10409 Positive_regulation TNF MAPK14 20844314 27763 Positive_regulation TNF MAPK14 20844314 28225 Positive_regulation TNF MAPK14 20939898 353651 Positive_regulation TNF MAPK14 21317295 717862 Positive_regulation TNF MAPK14 21485745 734880 Positive_regulation TNF MAPK14 21547253 1748956 Positive_regulation TNF MAPK14 21682898 122926 Positive_regulation TNF MAPK14 21961050 2224121 Positive_regulation TNF MAPK14 22069563 3181873 Positive_regulation TNF MAPK14 22315682 1687064 Positive_regulation TNF MAPK14 22455317 3210190 Positive_regulation TNF MAPK14 22524232 1661894 Positive_regulation TNF MAPK14 22611435 814309 Positive_regulation TNF MAPK14 22723938 2655180 Positive_regulation TNF MAPK14 22848503 2669185 Positive_regulation TNF MAPK14 23282009 1665868 Positive_regulation TNF MAPK14 23326086 1162766 Positive_regulation TNF MAPK14 23331383 1675470 Positive_regulation TNF MAPK14 23533994 180646 Positive_regulation TNF MAPK14 23549267 1104806 Positive_regulation TNF MAPK14 23549267 1104960 Positive_regulation TNF MAPK14 23549267 1105022 Positive_regulation TNF MAPK14 23549267 1105260 Positive_regulation TNF MAPK14 23557259 3215466 Positive_regulation TNF MAPK14 23557259 3215508 Positive_regulation TNF MAPK14 23755184 2801826 Positive_regulation TNF MAPK14 23799152 2807419 Positive_regulation TNF MAPK14 23908766 749699 Positive_regulation TNF MAPK14 23936634 140771 Positive_regulation TNF MAPK14 23967215 2834973 Positive_regulation TNF MAPK14 24008729 565089 Positive_regulation TNF MAPK14 24024042 2003199 Positive_regulation TNF MAPK14 24065916 973397 Positive_regulation TNF MAPK14 24101950 2227281 Positive_regulation TNF MAPK14 24307884 3155514 Positive_regulation TNF MAPK14 24376635 2901602 Positive_regulation TNF MAPK14 24377382 3225634 Positive_regulation TNF MAPK14 24381514 3155636 Positive_regulation TNF MAPK14 24421891 2909270 Positive_regulation TNF MAPK14 24423080 538860 Positive_regulation TNF MAPK14 24530567 1621209 Positive_regulation TNF MAPK14 24629023 1701468 Positive_regulation TNF MAPK14 24707477 188423 Positive_regulation TNF MAPK14 24747164 18897 Positive_regulation TNF MAPK14 24886088 347457 Positive_regulation TNF MAPK14 25025559 1162104 Positive_regulation TNF MAPK14 25025559 1162178 Positive_regulation TNF MAPK14 25180066 2229995 Positive_regulation TNF MAPK14 25435878 1074920 Positive_regulation TNF MAPK14 25606044 746882 Positive_regulation TNF MAPK14 8666946 1597644 Positive_regulation TNF MAPK15 11015442 1517365 Positive_regulation TNF MAPK15 11015442 1517404 Positive_regulation TNF MAPK15 11781369 1522162 Positive_regulation TNF MAPK15 12110137 99170 Positive_regulation TNF MAPK15 14960183 656417 Positive_regulation TNF MAPK15 16207331 104295 Positive_regulation TNF MAPK15 16542479 105133 Positive_regulation TNF MAPK15 16581537 792533 Positive_regulation TNF MAPK15 16581537 792561 Positive_regulation TNF MAPK15 16581537 792587 Positive_regulation TNF MAPK15 16581537 792613 Positive_regulation TNF MAPK15 16606437 658648 Positive_regulation TNF MAPK15 18410682 110391 Positive_regulation TNF MAPK15 18478117 2388659 Positive_regulation TNF MAPK15 19052649 1908506 Positive_regulation TNF MAPK15 19052649 1908545 Positive_regulation TNF MAPK15 19893201 736344 Positive_regulation TNF MAPK15 20089176 284006 Positive_regulation TNF MAPK15 20157567 26177 Positive_regulation TNF MAPK15 20157567 26430 Positive_regulation TNF MAPK15 20615213 119565 Positive_regulation TNF MAPK15 20644550 10403 Positive_regulation TNF MAPK15 20844314 27757 Positive_regulation TNF MAPK15 20844314 28219 Positive_regulation TNF MAPK15 20939898 353645 Positive_regulation TNF MAPK15 21317295 717854 Positive_regulation TNF MAPK15 21485745 734874 Positive_regulation TNF MAPK15 21547253 1748950 Positive_regulation TNF MAPK15 21682898 122919 Positive_regulation TNF MAPK15 21961050 2224115 Positive_regulation TNF MAPK15 22069563 3181867 Positive_regulation TNF MAPK15 22315682 1687058 Positive_regulation TNF MAPK15 22455317 3210182 Positive_regulation TNF MAPK15 22524232 1661888 Positive_regulation TNF MAPK15 22611435 814303 Positive_regulation TNF MAPK15 22723938 2655173 Positive_regulation TNF MAPK15 22848503 2669179 Positive_regulation TNF MAPK15 23282009 1665862 Positive_regulation TNF MAPK15 23326086 1162759 Positive_regulation TNF MAPK15 23331383 1675463 Positive_regulation TNF MAPK15 23533994 180640 Positive_regulation TNF MAPK15 23549267 1104800 Positive_regulation TNF MAPK15 23549267 1104954 Positive_regulation TNF MAPK15 23549267 1105016 Positive_regulation TNF MAPK15 23549267 1105254 Positive_regulation TNF MAPK15 23557259 3215460 Positive_regulation TNF MAPK15 23557259 3215502 Positive_regulation TNF MAPK15 23755184 2801820 Positive_regulation TNF MAPK15 23799152 2807413 Positive_regulation TNF MAPK15 23908766 749693 Positive_regulation TNF MAPK15 23936634 140765 Positive_regulation TNF MAPK15 23967215 2834967 Positive_regulation TNF MAPK15 24008729 565082 Positive_regulation TNF MAPK15 24024042 2003193 Positive_regulation TNF MAPK15 24065916 973391 Positive_regulation TNF MAPK15 24101950 2227275 Positive_regulation TNF MAPK15 24307884 3155508 Positive_regulation TNF MAPK15 24376635 2901596 Positive_regulation TNF MAPK15 24377382 3225628 Positive_regulation TNF MAPK15 24381514 3155630 Positive_regulation TNF MAPK15 24421891 2909264 Positive_regulation TNF MAPK15 24423080 538853 Positive_regulation TNF MAPK15 24530567 1621203 Positive_regulation TNF MAPK15 24629023 1701461 Positive_regulation TNF MAPK15 24707477 188417 Positive_regulation TNF MAPK15 24747164 18891 Positive_regulation TNF MAPK15 24886088 347451 Positive_regulation TNF MAPK15 25025559 1162098 Positive_regulation TNF MAPK15 25025559 1162172 Positive_regulation TNF MAPK15 25180066 2229989 Positive_regulation TNF MAPK15 25435878 1074914 Positive_regulation TNF MAPK15 25606044 746876 Positive_regulation TNF MAPK15 8666946 1597638 Positive_regulation TNF MAPK3 11015442 1517372 Positive_regulation TNF MAPK3 11015442 1517411 Positive_regulation TNF MAPK3 11781369 1522169 Positive_regulation TNF MAPK3 12110137 99177 Positive_regulation TNF MAPK3 14960183 656424 Positive_regulation TNF MAPK3 15545056 1739771 Positive_regulation TNF MAPK3 16207331 104302 Positive_regulation TNF MAPK3 16542479 105140 Positive_regulation TNF MAPK3 16581537 792540 Positive_regulation TNF MAPK3 16581537 792568 Positive_regulation TNF MAPK3 16581537 792594 Positive_regulation TNF MAPK3 16581537 792620 Positive_regulation TNF MAPK3 16606437 658655 Positive_regulation TNF MAPK3 18036262 1655164 Positive_regulation TNF MAPK3 18410682 110404 Positive_regulation TNF MAPK3 18478117 2388666 Positive_regulation TNF MAPK3 19052649 1908513 Positive_regulation TNF MAPK3 19052649 1908552 Positive_regulation TNF MAPK3 19893201 736351 Positive_regulation TNF MAPK3 20089176 284013 Positive_regulation TNF MAPK3 20157567 26184 Positive_regulation TNF MAPK3 20157567 26437 Positive_regulation TNF MAPK3 20615213 119573 Positive_regulation TNF MAPK3 20644550 10410 Positive_regulation TNF MAPK3 20844314 27764 Positive_regulation TNF MAPK3 20844314 28226 Positive_regulation TNF MAPK3 20939898 353652 Positive_regulation TNF MAPK3 21317295 717863 Positive_regulation TNF MAPK3 21485745 734881 Positive_regulation TNF MAPK3 21547253 1748957 Positive_regulation TNF MAPK3 21682898 122927 Positive_regulation TNF MAPK3 21961050 2224122 Positive_regulation TNF MAPK3 22069563 3181874 Positive_regulation TNF MAPK3 22279582 2590806 Positive_regulation TNF MAPK3 22315682 1687065 Positive_regulation TNF MAPK3 22379572 1710333 Positive_regulation TNF MAPK3 22455317 3210191 Positive_regulation TNF MAPK3 22524232 1661895 Positive_regulation TNF MAPK3 22611435 814310 Positive_regulation TNF MAPK3 22723938 2655181 Positive_regulation TNF MAPK3 22848503 2669186 Positive_regulation TNF MAPK3 22919361 3153833 Positive_regulation TNF MAPK3 23227067 3204524 Positive_regulation TNF MAPK3 23282009 1665869 Positive_regulation TNF MAPK3 23326086 1162767 Positive_regulation TNF MAPK3 23331383 1675471 Positive_regulation TNF MAPK3 23533994 180647 Positive_regulation TNF MAPK3 23549267 1104807 Positive_regulation TNF MAPK3 23549267 1104961 Positive_regulation TNF MAPK3 23549267 1105023 Positive_regulation TNF MAPK3 23549267 1105261 Positive_regulation TNF MAPK3 23557259 3215467 Positive_regulation TNF MAPK3 23557259 3215509 Positive_regulation TNF MAPK3 23587438 1666539 Positive_regulation TNF MAPK3 23587438 1666555 Positive_regulation TNF MAPK3 23587438 1666563 Positive_regulation TNF MAPK3 23755184 2801827 Positive_regulation TNF MAPK3 23799152 2807420 Positive_regulation TNF MAPK3 23908766 749700 Positive_regulation TNF MAPK3 23936634 140772 Positive_regulation TNF MAPK3 23967215 2834974 Positive_regulation TNF MAPK3 24008729 565090 Positive_regulation TNF MAPK3 24024042 2003200 Positive_regulation TNF MAPK3 24039713 2844609 Positive_regulation TNF MAPK3 24065916 973398 Positive_regulation TNF MAPK3 24086560 2854637 Positive_regulation TNF MAPK3 24101950 2227282 Positive_regulation TNF MAPK3 24307884 3155515 Positive_regulation TNF MAPK3 24376635 2901603 Positive_regulation TNF MAPK3 24377382 3225635 Positive_regulation TNF MAPK3 24381514 3155637 Positive_regulation TNF MAPK3 24421891 2909271 Positive_regulation TNF MAPK3 24423080 538861 Positive_regulation TNF MAPK3 24530567 1621210 Positive_regulation TNF MAPK3 24618100 1667752 Positive_regulation TNF MAPK3 24629023 1701469 Positive_regulation TNF MAPK3 24707477 188424 Positive_regulation TNF MAPK3 24722253 2951093 Positive_regulation TNF MAPK3 24747164 18898 Positive_regulation TNF MAPK3 24872677 743016 Positive_regulation TNF MAPK3 24886088 347458 Positive_regulation TNF MAPK3 25025559 1162105 Positive_regulation TNF MAPK3 25025559 1162179 Positive_regulation TNF MAPK3 25180066 2229996 Positive_regulation TNF MAPK3 25180066 2229997 Positive_regulation TNF MAPK3 25435878 1074921 Positive_regulation TNF MAPK3 25606044 746883 Positive_regulation TNF MAPK3 8666946 1597645 Positive_regulation TNF MAPK4 11015442 1517373 Positive_regulation TNF MAPK4 11015442 1517412 Positive_regulation TNF MAPK4 11781369 1522170 Positive_regulation TNF MAPK4 12110137 99178 Positive_regulation TNF MAPK4 14960183 656425 Positive_regulation TNF MAPK4 16207331 104303 Positive_regulation TNF MAPK4 16542479 105141 Positive_regulation TNF MAPK4 16581537 792541 Positive_regulation TNF MAPK4 16581537 792569 Positive_regulation TNF MAPK4 16581537 792595 Positive_regulation TNF MAPK4 16581537 792621 Positive_regulation TNF MAPK4 16606437 658656 Positive_regulation TNF MAPK4 18410682 110405 Positive_regulation TNF MAPK4 18478117 2388667 Positive_regulation TNF MAPK4 19052649 1908514 Positive_regulation TNF MAPK4 19052649 1908553 Positive_regulation TNF MAPK4 19893201 736352 Positive_regulation TNF MAPK4 20089176 284014 Positive_regulation TNF MAPK4 20157567 26185 Positive_regulation TNF MAPK4 20157567 26438 Positive_regulation TNF MAPK4 20615213 119574 Positive_regulation TNF MAPK4 20644550 10411 Positive_regulation TNF MAPK4 20844314 27765 Positive_regulation TNF MAPK4 20844314 28227 Positive_regulation TNF MAPK4 20939898 353653 Positive_regulation TNF MAPK4 21317295 717864 Positive_regulation TNF MAPK4 21485745 734882 Positive_regulation TNF MAPK4 21547253 1748958 Positive_regulation TNF MAPK4 21682898 122928 Positive_regulation TNF MAPK4 21961050 2224123 Positive_regulation TNF MAPK4 22069563 3181875 Positive_regulation TNF MAPK4 22315682 1687066 Positive_regulation TNF MAPK4 22455317 3210192 Positive_regulation TNF MAPK4 22524232 1661896 Positive_regulation TNF MAPK4 22611435 814311 Positive_regulation TNF MAPK4 22723938 2655182 Positive_regulation TNF MAPK4 22848503 2669187 Positive_regulation TNF MAPK4 23282009 1665870 Positive_regulation TNF MAPK4 23326086 1162768 Positive_regulation TNF MAPK4 23331383 1675472 Positive_regulation TNF MAPK4 23533994 180648 Positive_regulation TNF MAPK4 23549267 1104808 Positive_regulation TNF MAPK4 23549267 1104962 Positive_regulation TNF MAPK4 23549267 1105024 Positive_regulation TNF MAPK4 23549267 1105262 Positive_regulation TNF MAPK4 23557259 3215468 Positive_regulation TNF MAPK4 23557259 3215510 Positive_regulation TNF MAPK4 23755184 2801828 Positive_regulation TNF MAPK4 23799152 2807421 Positive_regulation TNF MAPK4 23908766 749701 Positive_regulation TNF MAPK4 23936634 140773 Positive_regulation TNF MAPK4 23967215 2834975 Positive_regulation TNF MAPK4 24008729 565091 Positive_regulation TNF MAPK4 24024042 2003201 Positive_regulation TNF MAPK4 24065916 973399 Positive_regulation TNF MAPK4 24101950 2227283 Positive_regulation TNF MAPK4 24307884 3155516 Positive_regulation TNF MAPK4 24376635 2901604 Positive_regulation TNF MAPK4 24377382 3225636 Positive_regulation TNF MAPK4 24381514 3155638 Positive_regulation TNF MAPK4 24421891 2909272 Positive_regulation TNF MAPK4 24423080 538862 Positive_regulation TNF MAPK4 24530567 1621211 Positive_regulation TNF MAPK4 24629023 1701470 Positive_regulation TNF MAPK4 24707477 188425 Positive_regulation TNF MAPK4 24747164 18899 Positive_regulation TNF MAPK4 24886088 347459 Positive_regulation TNF MAPK4 25025559 1162106 Positive_regulation TNF MAPK4 25025559 1162180 Positive_regulation TNF MAPK4 25180066 2229998 Positive_regulation TNF MAPK4 25435878 1074922 Positive_regulation TNF MAPK4 25606044 746884 Positive_regulation TNF MAPK4 8666946 1597646 Positive_regulation TNF MAPK6 11015442 1517374 Positive_regulation TNF MAPK6 11015442 1517413 Positive_regulation TNF MAPK6 11781369 1522171 Positive_regulation TNF MAPK6 12110137 99179 Positive_regulation TNF MAPK6 14960183 656426 Positive_regulation TNF MAPK6 16207331 104304 Positive_regulation TNF MAPK6 16542479 105142 Positive_regulation TNF MAPK6 16581537 792542 Positive_regulation TNF MAPK6 16581537 792570 Positive_regulation TNF MAPK6 16581537 792596 Positive_regulation TNF MAPK6 16581537 792622 Positive_regulation TNF MAPK6 16606437 658657 Positive_regulation TNF MAPK6 18410682 110406 Positive_regulation TNF MAPK6 18478117 2388668 Positive_regulation TNF MAPK6 19052649 1908515 Positive_regulation TNF MAPK6 19052649 1908554 Positive_regulation TNF MAPK6 19893201 736353 Positive_regulation TNF MAPK6 20089176 284015 Positive_regulation TNF MAPK6 20157567 26186 Positive_regulation TNF MAPK6 20157567 26439 Positive_regulation TNF MAPK6 20615213 119575 Positive_regulation TNF MAPK6 20644550 10412 Positive_regulation TNF MAPK6 20844314 27766 Positive_regulation TNF MAPK6 20844314 28228 Positive_regulation TNF MAPK6 20939898 353654 Positive_regulation TNF MAPK6 21317295 717865 Positive_regulation TNF MAPK6 21485745 734883 Positive_regulation TNF MAPK6 21547253 1748959 Positive_regulation TNF MAPK6 21682898 122929 Positive_regulation TNF MAPK6 21961050 2224124 Positive_regulation TNF MAPK6 22069563 3181876 Positive_regulation TNF MAPK6 22315682 1687067 Positive_regulation TNF MAPK6 22455317 3210193 Positive_regulation TNF MAPK6 22524232 1661897 Positive_regulation TNF MAPK6 22611435 814312 Positive_regulation TNF MAPK6 22723938 2655183 Positive_regulation TNF MAPK6 22848503 2669188 Positive_regulation TNF MAPK6 23282009 1665871 Positive_regulation TNF MAPK6 23326086 1162769 Positive_regulation TNF MAPK6 23331383 1675473 Positive_regulation TNF MAPK6 23533994 180649 Positive_regulation TNF MAPK6 23549267 1104809 Positive_regulation TNF MAPK6 23549267 1104963 Positive_regulation TNF MAPK6 23549267 1105025 Positive_regulation TNF MAPK6 23549267 1105263 Positive_regulation TNF MAPK6 23557259 3215469 Positive_regulation TNF MAPK6 23557259 3215511 Positive_regulation TNF MAPK6 23755184 2801829 Positive_regulation TNF MAPK6 23799152 2807422 Positive_regulation TNF MAPK6 23908766 749702 Positive_regulation TNF MAPK6 23936634 140774 Positive_regulation TNF MAPK6 23967215 2834976 Positive_regulation TNF MAPK6 24008729 565092 Positive_regulation TNF MAPK6 24024042 2003202 Positive_regulation TNF MAPK6 24065916 973400 Positive_regulation TNF MAPK6 24101950 2227284 Positive_regulation TNF MAPK6 24307884 3155517 Positive_regulation TNF MAPK6 24376635 2901605 Positive_regulation TNF MAPK6 24377382 3225637 Positive_regulation TNF MAPK6 24381514 3155639 Positive_regulation TNF MAPK6 24421891 2909273 Positive_regulation TNF MAPK6 24423080 538863 Positive_regulation TNF MAPK6 24530567 1621212 Positive_regulation TNF MAPK6 24629023 1701471 Positive_regulation TNF MAPK6 24707477 188426 Positive_regulation TNF MAPK6 24747164 18900 Positive_regulation TNF MAPK6 24886088 347460 Positive_regulation TNF MAPK6 25025559 1162107 Positive_regulation TNF MAPK6 25025559 1162181 Positive_regulation TNF MAPK6 25180066 2229999 Positive_regulation TNF MAPK6 25435878 1074923 Positive_regulation TNF MAPK6 25606044 746885 Positive_regulation TNF MAPK6 8666946 1597647 Positive_regulation TNF MAPK7 11015442 1517375 Positive_regulation TNF MAPK7 11015442 1517414 Positive_regulation TNF MAPK7 11781369 1522172 Positive_regulation TNF MAPK7 12110137 99180 Positive_regulation TNF MAPK7 14960183 656427 Positive_regulation TNF MAPK7 16207331 104305 Positive_regulation TNF MAPK7 16542479 105143 Positive_regulation TNF MAPK7 16581537 792543 Positive_regulation TNF MAPK7 16581537 792571 Positive_regulation TNF MAPK7 16581537 792597 Positive_regulation TNF MAPK7 16581537 792623 Positive_regulation TNF MAPK7 16606437 658658 Positive_regulation TNF MAPK7 18410682 110407 Positive_regulation TNF MAPK7 18478117 2388669 Positive_regulation TNF MAPK7 19052649 1908516 Positive_regulation TNF MAPK7 19052649 1908555 Positive_regulation TNF MAPK7 19893201 736354 Positive_regulation TNF MAPK7 20089176 284016 Positive_regulation TNF MAPK7 20157567 26187 Positive_regulation TNF MAPK7 20157567 26440 Positive_regulation TNF MAPK7 20615213 119576 Positive_regulation TNF MAPK7 20644550 10413 Positive_regulation TNF MAPK7 20844314 27767 Positive_regulation TNF MAPK7 20844314 28229 Positive_regulation TNF MAPK7 20939898 353655 Positive_regulation TNF MAPK7 21317295 717866 Positive_regulation TNF MAPK7 21485745 734884 Positive_regulation TNF MAPK7 21547253 1748960 Positive_regulation TNF MAPK7 21682898 122930 Positive_regulation TNF MAPK7 21961050 2224125 Positive_regulation TNF MAPK7 22069563 3181877 Positive_regulation TNF MAPK7 22315682 1687068 Positive_regulation TNF MAPK7 22455317 3210194 Positive_regulation TNF MAPK7 22524232 1661898 Positive_regulation TNF MAPK7 22611435 814313 Positive_regulation TNF MAPK7 22723938 2655184 Positive_regulation TNF MAPK7 22848503 2669189 Positive_regulation TNF MAPK7 23282009 1665872 Positive_regulation TNF MAPK7 23326086 1162770 Positive_regulation TNF MAPK7 23331383 1675474 Positive_regulation TNF MAPK7 23533994 180650 Positive_regulation TNF MAPK7 23549267 1104810 Positive_regulation TNF MAPK7 23549267 1104964 Positive_regulation TNF MAPK7 23549267 1105026 Positive_regulation TNF MAPK7 23549267 1105264 Positive_regulation TNF MAPK7 23557259 3215470 Positive_regulation TNF MAPK7 23557259 3215512 Positive_regulation TNF MAPK7 23755184 2801830 Positive_regulation TNF MAPK7 23799152 2807423 Positive_regulation TNF MAPK7 23908766 749703 Positive_regulation TNF MAPK7 23936634 140775 Positive_regulation TNF MAPK7 23967215 2834977 Positive_regulation TNF MAPK7 24008729 565093 Positive_regulation TNF MAPK7 24024042 2003203 Positive_regulation TNF MAPK7 24065916 973401 Positive_regulation TNF MAPK7 24101950 2227285 Positive_regulation TNF MAPK7 24307884 3155518 Positive_regulation TNF MAPK7 24376635 2901606 Positive_regulation TNF MAPK7 24377382 3225638 Positive_regulation TNF MAPK7 24381514 3155640 Positive_regulation TNF MAPK7 24421891 2909274 Positive_regulation TNF MAPK7 24423080 538864 Positive_regulation TNF MAPK7 24530567 1621213 Positive_regulation TNF MAPK7 24629023 1701472 Positive_regulation TNF MAPK7 24707477 188427 Positive_regulation TNF MAPK7 24747164 18901 Positive_regulation TNF MAPK7 24886088 347461 Positive_regulation TNF MAPK7 25025559 1162108 Positive_regulation TNF MAPK7 25025559 1162182 Positive_regulation TNF MAPK7 25180066 2230000 Positive_regulation TNF MAPK7 25435878 1074924 Positive_regulation TNF MAPK7 25606044 746886 Positive_regulation TNF MAPK7 8666946 1597648 Positive_regulation TNF MAPK8 11015442 1517376 Positive_regulation TNF MAPK8 11015442 1517415 Positive_regulation TNF MAPK8 11781369 1522173 Positive_regulation TNF MAPK8 12110137 99181 Positive_regulation TNF MAPK8 14960183 656428 Positive_regulation TNF MAPK8 16207331 104306 Positive_regulation TNF MAPK8 16542479 105144 Positive_regulation TNF MAPK8 16581537 792544 Positive_regulation TNF MAPK8 16581537 792572 Positive_regulation TNF MAPK8 16581537 792598 Positive_regulation TNF MAPK8 16581537 792624 Positive_regulation TNF MAPK8 16606437 658659 Positive_regulation TNF MAPK8 17567906 370593 Positive_regulation TNF MAPK8 17567906 370615 Positive_regulation TNF MAPK8 18410682 110408 Positive_regulation TNF MAPK8 18478117 2388670 Positive_regulation TNF MAPK8 18773087 2396157 Positive_regulation TNF MAPK8 19052649 1908517 Positive_regulation TNF MAPK8 19052649 1908556 Positive_regulation TNF MAPK8 19893201 736355 Positive_regulation TNF MAPK8 20089176 284017 Positive_regulation TNF MAPK8 20157567 26188 Positive_regulation TNF MAPK8 20157567 26441 Positive_regulation TNF MAPK8 20615213 119577 Positive_regulation TNF MAPK8 20644550 10414 Positive_regulation TNF MAPK8 20844314 27768 Positive_regulation TNF MAPK8 20844314 28230 Positive_regulation TNF MAPK8 20939898 353656 Positive_regulation TNF MAPK8 21317295 717867 Positive_regulation TNF MAPK8 21485745 734885 Positive_regulation TNF MAPK8 21547253 1748961 Positive_regulation TNF MAPK8 21682898 122931 Positive_regulation TNF MAPK8 21961050 2224126 Positive_regulation TNF MAPK8 22069563 3181878 Positive_regulation TNF MAPK8 22279582 2590807 Positive_regulation TNF MAPK8 22315682 1687069 Positive_regulation TNF MAPK8 22455317 3210195 Positive_regulation TNF MAPK8 22524232 1661899 Positive_regulation TNF MAPK8 22611435 814314 Positive_regulation TNF MAPK8 22723938 2655185 Positive_regulation TNF MAPK8 22848503 2669190 Positive_regulation TNF MAPK8 23282009 1665873 Positive_regulation TNF MAPK8 23326086 1162771 Positive_regulation TNF MAPK8 23331383 1675475 Positive_regulation TNF MAPK8 23533994 180651 Positive_regulation TNF MAPK8 23549267 1104811 Positive_regulation TNF MAPK8 23549267 1104965 Positive_regulation TNF MAPK8 23549267 1105027 Positive_regulation TNF MAPK8 23549267 1105265 Positive_regulation TNF MAPK8 23557259 3215471 Positive_regulation TNF MAPK8 23557259 3215513 Positive_regulation TNF MAPK8 23755184 2801831 Positive_regulation TNF MAPK8 23799152 2807424 Positive_regulation TNF MAPK8 23908766 749704 Positive_regulation TNF MAPK8 23936634 140776 Positive_regulation TNF MAPK8 23967215 2834978 Positive_regulation TNF MAPK8 24008729 565094 Positive_regulation TNF MAPK8 24024042 2003204 Positive_regulation TNF MAPK8 24065916 973402 Positive_regulation TNF MAPK8 24086560 2854638 Positive_regulation TNF MAPK8 24101950 2227286 Positive_regulation TNF MAPK8 24307884 3155519 Positive_regulation TNF MAPK8 24376635 2901607 Positive_regulation TNF MAPK8 24377382 3225639 Positive_regulation TNF MAPK8 24381514 3155641 Positive_regulation TNF MAPK8 24421891 2909275 Positive_regulation TNF MAPK8 24423080 538865 Positive_regulation TNF MAPK8 24530567 1621214 Positive_regulation TNF MAPK8 24618100 1667753 Positive_regulation TNF MAPK8 24629023 1701473 Positive_regulation TNF MAPK8 24707477 188428 Positive_regulation TNF MAPK8 24747164 18902 Positive_regulation TNF MAPK8 24886088 347462 Positive_regulation TNF MAPK8 25025559 1162109 Positive_regulation TNF MAPK8 25025559 1162183 Positive_regulation TNF MAPK8 25180066 2230001 Positive_regulation TNF MAPK8 25435878 1074925 Positive_regulation TNF MAPK8 25606044 746887 Positive_regulation TNF MAPK8 8666946 1597649 Positive_regulation TNF MAPK9 11015442 1517377 Positive_regulation TNF MAPK9 11015442 1517416 Positive_regulation TNF MAPK9 11781369 1522174 Positive_regulation TNF MAPK9 12110137 99182 Positive_regulation TNF MAPK9 14960183 656429 Positive_regulation TNF MAPK9 16207331 104307 Positive_regulation TNF MAPK9 16542479 105145 Positive_regulation TNF MAPK9 16581537 792545 Positive_regulation TNF MAPK9 16581537 792573 Positive_regulation TNF MAPK9 16581537 792599 Positive_regulation TNF MAPK9 16581537 792625 Positive_regulation TNF MAPK9 16606437 658660 Positive_regulation TNF MAPK9 18410682 110409 Positive_regulation TNF MAPK9 18478117 2388671 Positive_regulation TNF MAPK9 19052649 1908518 Positive_regulation TNF MAPK9 19052649 1908557 Positive_regulation TNF MAPK9 19893201 736356 Positive_regulation TNF MAPK9 20089176 284018 Positive_regulation TNF MAPK9 20157567 26189 Positive_regulation TNF MAPK9 20157567 26442 Positive_regulation TNF MAPK9 20615213 119578 Positive_regulation TNF MAPK9 20644550 10415 Positive_regulation TNF MAPK9 20844314 27769 Positive_regulation TNF MAPK9 20844314 28231 Positive_regulation TNF MAPK9 20939898 353657 Positive_regulation TNF MAPK9 21317295 717868 Positive_regulation TNF MAPK9 21485745 734886 Positive_regulation TNF MAPK9 21547253 1748962 Positive_regulation TNF MAPK9 21682898 122932 Positive_regulation TNF MAPK9 21961050 2224127 Positive_regulation TNF MAPK9 22069563 3181879 Positive_regulation TNF MAPK9 22315682 1687070 Positive_regulation TNF MAPK9 22455317 3210196 Positive_regulation TNF MAPK9 22524232 1661900 Positive_regulation TNF MAPK9 22611435 814315 Positive_regulation TNF MAPK9 22723938 2655186 Positive_regulation TNF MAPK9 22848503 2669191 Positive_regulation TNF MAPK9 23282009 1665874 Positive_regulation TNF MAPK9 23326086 1162772 Positive_regulation TNF MAPK9 23331383 1675476 Positive_regulation TNF MAPK9 23533994 180652 Positive_regulation TNF MAPK9 23549267 1104812 Positive_regulation TNF MAPK9 23549267 1104966 Positive_regulation TNF MAPK9 23549267 1105028 Positive_regulation TNF MAPK9 23549267 1105266 Positive_regulation TNF MAPK9 23557259 3215472 Positive_regulation TNF MAPK9 23557259 3215514 Positive_regulation TNF MAPK9 23755184 2801832 Positive_regulation TNF MAPK9 23799152 2807425 Positive_regulation TNF MAPK9 23908766 749705 Positive_regulation TNF MAPK9 23936634 140777 Positive_regulation TNF MAPK9 23967215 2834979 Positive_regulation TNF MAPK9 24008729 565095 Positive_regulation TNF MAPK9 24024042 2003205 Positive_regulation TNF MAPK9 24065916 973403 Positive_regulation TNF MAPK9 24101950 2227287 Positive_regulation TNF MAPK9 24307884 3155520 Positive_regulation TNF MAPK9 24376635 2901608 Positive_regulation TNF MAPK9 24377382 3225640 Positive_regulation TNF MAPK9 24381514 3155642 Positive_regulation TNF MAPK9 24421891 2909276 Positive_regulation TNF MAPK9 24423080 538866 Positive_regulation TNF MAPK9 24530567 1621215 Positive_regulation TNF MAPK9 24629023 1701474 Positive_regulation TNF MAPK9 24707477 188429 Positive_regulation TNF MAPK9 24747164 18903 Positive_regulation TNF MAPK9 24886088 347463 Positive_regulation TNF MAPK9 25025559 1162110 Positive_regulation TNF MAPK9 25025559 1162184 Positive_regulation TNF MAPK9 25180066 2230002 Positive_regulation TNF MAPK9 25435878 1074926 Positive_regulation TNF MAPK9 25606044 746888 Positive_regulation TNF MAPK9 8666946 1597650 Positive_regulation TNF MAPKAPK2 12486099 1525581 Positive_regulation TNF MAPKAPK2 20230629 402479 Positive_regulation TNF MAPKAPK2 22991685 1082650 Positive_regulation TNF MAPKAPK2 23028373 2338485 Positive_regulation TNF MAPKAPK2 24705157 985048 Positive_regulation TNF MAPKAPK2 25386251 696613 Positive_regulation TNF MAPKAPK3 24705157 985039 Positive_regulation TNF MAPKAPK3 PMC4118437 809585 Positive_regulation TNF MAPRE3 20818435 2136206 Positive_regulation TNF MARC1 23148668 3215180 Positive_regulation TNF MAT2B 24212770 498146 Positive_regulation TNF MBL2 18180310 1548232 Positive_regulation TNF MBL2 18180310 1548233 Positive_regulation TNF MBL2 18180310 1548236 Positive_regulation TNF MBL2 18180310 1548238 Positive_regulation TNF MBL2 18180310 1548240 Positive_regulation TNF MBL2 18180310 1548241 Positive_regulation TNF MBL2 18180310 1548245 Positive_regulation TNF MBL2 24391778 2904465 Positive_regulation TNF MBOAT1 20419140 2447179 Positive_regulation TNF MBOAT1 23951185 2833668 Positive_regulation TNF MBOAT1 24165011 3123866 Positive_regulation TNF MBP 23554784 1226215 Positive_regulation TNF MBS1 24498365 2919257 Positive_regulation TNF MBTPS1 20577214 1985417 Positive_regulation TNF MBTPS1 22096531 2571667 Positive_regulation TNF MBTPS1 24058758 1704958 Positive_regulation TNF MBTPS1 24058758 1704967 Positive_regulation TNF MBTPS1 24058758 1704968 Positive_regulation TNF MBTPS1 24586752 2926272 Positive_regulation TNF MBTPS1 24586752 2926292 Positive_regulation TNF MBTPS1 24586752 2926293 Positive_regulation TNF MBTPS1 24586752 2926301 Positive_regulation TNF MCRS1 25258680 1675224 Positive_regulation TNF MCS 21980488 2560955 Positive_regulation TNF MEA1 23755184 2801867 Positive_regulation TNF MED1 18410682 110411 Positive_regulation TNF MED1 19712471 1625660 Positive_regulation TNF MED1 20454616 2449464 Positive_regulation TNF MED1 22046231 2566149 Positive_regulation TNF MED1 22691272 126188 Positive_regulation TNF MED1 24971461 2984422 Positive_regulation TNF MED1 7540649 1590319 Positive_regulation TNF MED1 PMC2799006 1146794 Positive_regulation TNF MED10 18410682 110393 Positive_regulation TNF MED10 19712471 1625659 Positive_regulation TNF MED10 20454616 2449459 Positive_regulation TNF MED10 22691272 126183 Positive_regulation TNF MED10 24971461 2984417 Positive_regulation TNF MED10 7540649 1590315 Positive_regulation TNF MED10 PMC2799006 1146789 Positive_regulation TNF MED11 18410682 110396 Positive_regulation TNF MED11 20454616 2449462 Positive_regulation TNF MED11 22691272 126186 Positive_regulation TNF MED11 24971461 2984420 Positive_regulation TNF MED11 7540649 1590318 Positive_regulation TNF MED11 PMC2799006 1146792 Positive_regulation TNF MED12 19712471 1625647 Positive_regulation TNF MED12 24971461 2984392 Positive_regulation TNF MED12 7540649 1590290 Positive_regulation TNF MED13 18410682 110379 Positive_regulation TNF MED13 19712471 1625652 Positive_regulation TNF MED13 20454616 2449446 Positive_regulation TNF MED13 22691272 126170 Positive_regulation TNF MED13 24971461 2984402 Positive_regulation TNF MED13 7540649 1590300 Positive_regulation TNF MED13 PMC2799006 1146776 Positive_regulation TNF MED13L 18410682 110380 Positive_regulation TNF MED13L 20454616 2449447 Positive_regulation TNF MED13L 22691272 126171 Positive_regulation TNF MED13L 24971461 2984403 Positive_regulation TNF MED13L 7540649 1590301 Positive_regulation TNF MED13L PMC2799006 1146777 Positive_regulation TNF MED14 18410682 110384 Positive_regulation TNF MED14 19712471 1625655 Positive_regulation TNF MED14 20454616 2449451 Positive_regulation TNF MED14 22691272 126175 Positive_regulation TNF MED14 24971461 2984407 Positive_regulation TNF MED14 7540649 1590305 Positive_regulation TNF MED14 PMC2799006 1146781 Positive_regulation TNF MED15 18410682 110373 Positive_regulation TNF MED15 20454616 2449440 Positive_regulation TNF MED15 22691272 126162 Positive_regulation TNF MED15 24971461 2984393 Positive_regulation TNF MED15 7540649 1590291 Positive_regulation TNF MED15 PMC2799006 1146770 Positive_regulation TNF MED16 18410682 110375 Positive_regulation TNF MED16 19712471 1625649 Positive_regulation TNF MED16 20454616 2449442 Positive_regulation TNF MED16 22691272 126166 Positive_regulation TNF MED16 24971461 2984396 Positive_regulation TNF MED16 7540649 1590294 Positive_regulation TNF MED16 PMC2799006 1146772 Positive_regulation TNF MED17 18410682 110386 Positive_regulation TNF MED17 19712471 1625656 Positive_regulation TNF MED17 20454616 2449453 Positive_regulation TNF MED17 22691272 126177 Positive_regulation TNF MED17 24971461 2984409 Positive_regulation TNF MED17 7540649 1590307 Positive_regulation TNF MED17 PMC2799006 1146783 Positive_regulation TNF MED18 18410682 110392 Positive_regulation TNF MED18 20454616 2449458 Positive_regulation TNF MED18 22691272 126182 Positive_regulation TNF MED18 24971461 2984416 Positive_regulation TNF MED18 7540649 1590314 Positive_regulation TNF MED18 PMC2799006 1146788 Positive_regulation TNF MED19 18410682 110395 Positive_regulation TNF MED19 20454616 2449461 Positive_regulation TNF MED19 22691272 126185 Positive_regulation TNF MED19 24971461 2984419 Positive_regulation TNF MED19 7540649 1590317 Positive_regulation TNF MED19 PMC2799006 1146791 Positive_regulation TNF MED20 18410682 110374 Positive_regulation TNF MED20 20454616 2449441 Positive_regulation TNF MED20 22691272 126165 Positive_regulation TNF MED20 24971461 2984395 Positive_regulation TNF MED20 7540649 1590293 Positive_regulation TNF MED20 PMC2799006 1146771 Positive_regulation TNF MED21 18410682 110371 Positive_regulation TNF MED21 19712471 1625645 Positive_regulation TNF MED21 20454616 2449438 Positive_regulation TNF MED21 22691272 126160 Positive_regulation TNF MED21 24971461 2984389 Positive_regulation TNF MED21 7540649 1590288 Positive_regulation TNF MED21 PMC2799006 1146768 Positive_regulation TNF MED22 18410682 110372 Positive_regulation TNF MED22 20454616 2449439 Positive_regulation TNF MED22 22691272 126161 Positive_regulation TNF MED22 24971461 2984390 Positive_regulation TNF MED22 7540649 1590289 Positive_regulation TNF MED22 PMC2799006 1146769 Positive_regulation TNF MED23 18410682 110385 Positive_regulation TNF MED23 20454616 2449452 Positive_regulation TNF MED23 22691272 126176 Positive_regulation TNF MED23 24971461 2984408 Positive_regulation TNF MED23 7540649 1590306 Positive_regulation TNF MED23 PMC2799006 1146782 Positive_regulation TNF MED24 18410682 110381 Positive_regulation TNF MED24 19712471 1625653 Positive_regulation TNF MED24 20454616 2449448 Positive_regulation TNF MED24 22691272 126172 Positive_regulation TNF MED24 24971461 2984404 Positive_regulation TNF MED24 7540649 1590302 Positive_regulation TNF MED24 PMC2799006 1146778 Positive_regulation TNF MED25 18410682 110394 Positive_regulation TNF MED25 20454616 2449460 Positive_regulation TNF MED25 22691272 126184 Positive_regulation TNF MED25 24971461 2984418 Positive_regulation TNF MED25 7540649 1590316 Positive_regulation TNF MED25 PMC2799006 1146790 Positive_regulation TNF MED26 18410682 110387 Positive_regulation TNF MED26 20454616 2449454 Positive_regulation TNF MED26 22691272 126178 Positive_regulation TNF MED26 24971461 2984410 Positive_regulation TNF MED26 7540649 1590308 Positive_regulation TNF MED26 PMC2799006 1146784 Positive_regulation TNF MED27 18410682 110388 Positive_regulation TNF MED27 19712471 1625657 Positive_regulation TNF MED27 20454616 2449455 Positive_regulation TNF MED27 22691272 126179 Positive_regulation TNF MED27 24971461 2984411 Positive_regulation TNF MED27 7540649 1590309 Positive_regulation TNF MED27 PMC2799006 1146785 Positive_regulation TNF MED28 24971461 2984414 Positive_regulation TNF MED28 7540649 1590312 Positive_regulation TNF MED29 18410682 110383 Positive_regulation TNF MED29 20454616 2449450 Positive_regulation TNF MED29 22691272 126174 Positive_regulation TNF MED29 24971461 2984406 Positive_regulation TNF MED29 7540649 1590304 Positive_regulation TNF MED29 PMC2799006 1146780 Positive_regulation TNF MED30 18410682 110382 Positive_regulation TNF MED30 20454616 2449449 Positive_regulation TNF MED30 22691272 126173 Positive_regulation TNF MED30 24971461 2984405 Positive_regulation TNF MED30 7540649 1590303 Positive_regulation TNF MED30 PMC2799006 1146779 Positive_regulation TNF MED31 18410682 110390 Positive_regulation TNF MED31 19712471 1625658 Positive_regulation TNF MED31 20454616 2449457 Positive_regulation TNF MED31 22691272 126181 Positive_regulation TNF MED31 24971461 2984413 Positive_regulation TNF MED31 7540649 1590311 Positive_regulation TNF MED31 PMC2799006 1146787 Positive_regulation TNF MED4 18410682 110376 Positive_regulation TNF MED4 19712471 1625650 Positive_regulation TNF MED4 20454616 2449443 Positive_regulation TNF MED4 22691272 126167 Positive_regulation TNF MED4 24971461 2984398 Positive_regulation TNF MED4 7540649 1590296 Positive_regulation TNF MED4 PMC2799006 1146773 Positive_regulation TNF MED6 18410682 110377 Positive_regulation TNF MED6 19712471 1625651 Positive_regulation TNF MED6 20454616 2449444 Positive_regulation TNF MED6 22691272 126168 Positive_regulation TNF MED6 24971461 2984400 Positive_regulation TNF MED6 7540649 1590298 Positive_regulation TNF MED6 PMC2799006 1146774 Positive_regulation TNF MED7 18410682 110389 Positive_regulation TNF MED7 20454616 2449456 Positive_regulation TNF MED7 22691272 126180 Positive_regulation TNF MED7 24971461 2984412 Positive_regulation TNF MED7 7540649 1590310 Positive_regulation TNF MED7 PMC2799006 1146786 Positive_regulation TNF MED8 18410682 110378 Positive_regulation TNF MED8 20454616 2449445 Positive_regulation TNF MED8 22691272 126169 Positive_regulation TNF MED8 24971461 2984401 Positive_regulation TNF MED8 7540649 1590299 Positive_regulation TNF MED8 PMC2799006 1146775 Positive_regulation TNF MED9 24971461 2984415 Positive_regulation TNF MED9 7540649 1590313 Positive_regulation TNF MET 20811626 2473313 Positive_regulation TNF MET 25060092 850502 Positive_regulation TNF MFAP2 21274433 632267 Positive_regulation TNF MGAT1 8920862 1599462 Positive_regulation TNF MIA 23861563 1754239 Positive_regulation TNF MIA 24282543 2886293 Positive_regulation TNF MICE 24008733 565895 Positive_regulation TNF MICE 24205293 2875908 Positive_regulation TNF MIF 10877450 1737108 Positive_regulation TNF MIF 11094508 658210 Positive_regulation TNF MIF 12782713 1527472 Positive_regulation TNF MIF 16677407 658678 Positive_regulation TNF MIF 17029647 1727736 Positive_regulation TNF MIF 18475620 1744849 Positive_regulation TNF MIF 18723565 90809 Positive_regulation TNF MIF 18723565 90811 Positive_regulation TNF MIF 18723565 90814 Positive_regulation TNF MIF 20830230 1711853 Positive_regulation TNF MIF 20830230 1711860 Positive_regulation TNF MIF 20939898 353658 Positive_regulation TNF MIF 20939898 353659 Positive_regulation TNF MIF 20939898 353716 Positive_regulation TNF MIF 20939898 353737 Positive_regulation TNF MIF 21087445 645647 Positive_regulation TNF MIF 21401926 121791 Positive_regulation TNF MIF 21977228 2559768 Positive_regulation TNF MIF 22096364 1628336 Positive_regulation TNF MIF 22096364 1628354 Positive_regulation TNF MIF 22267916 983515 Positive_regulation TNF MIF 22496958 1680468 Positive_regulation TNF MIF 22496958 1680473 Positive_regulation TNF MIF 22496958 1680483 Positive_regulation TNF MIF 22629429 2646474 Positive_regulation TNF MIF 22952837 2684253 Positive_regulation TNF MIF 22973314 1068863 Positive_regulation TNF MIF 22973314 1069081 Positive_regulation TNF MIF 23050964 89450 Positive_regulation TNF MIF 23383040 2747649 Positive_regulation TNF MIF 23451183 2758311 Positive_regulation TNF MIF 23451183 2758312 Positive_regulation TNF MIF 23853427 1754089 Positive_regulation TNF MIF 24069610 184237 Positive_regulation TNF MIF 24133408 938330 Positive_regulation TNF MIF 24527464 1495671 Positive_regulation TNF MIF 25255103 3069555 Positive_regulation TNF MIF 25255103 3069564 Positive_regulation TNF MIF 8551232 1595846 Positive_regulation TNF MIF 8551232 1595851 Positive_regulation TNF MIF 9892616 1605065 Positive_regulation TNF MIP 20846396 353602 Positive_regulation TNF MIP 20846396 353607 Positive_regulation TNF MIP 20846396 353611 Positive_regulation TNF MIP 21811611 2539723 Positive_regulation TNF MIP 24058610 2848243 Positive_regulation TNF MIP 3279154 1580742 Positive_regulation TNF MIP 8496676 1595575 Positive_regulation TNF MIPEP 17893200 1547184 Positive_regulation TNF MIPEP 20846396 353612 Positive_regulation TNF MIPEP 20846396 353613 Positive_regulation TNF MIPEP 22110387 1058545 Positive_regulation TNF MIR155 24073882 1490621 Positive_regulation TNF MLKL 23835476 611274 Positive_regulation TNF MLKL 24090154 537729 Positive_regulation TNF MLKL 24366341 612183 Positive_regulation TNF MLYCD 19847289 2429168 Positive_regulation TNF MLYCD 19847289 2429175 Positive_regulation TNF MLYCD 19847289 2429176 Positive_regulation TNF MLYCD 22319522 832512 Positive_regulation TNF MMP1 14979937 100139 Positive_regulation TNF MMP1 19281072 1071643 Positive_regulation TNF MMP1 19435506 113236 Positive_regulation TNF MMP1 19706153 3109754 Positive_regulation TNF MMP1 20126546 2439092 Positive_regulation TNF MMP1 20126546 2439137 Positive_regulation TNF MMP1 21217769 12303 Positive_regulation TNF MMP1 22899878 1750218 Positive_regulation TNF MMP1 24552146 295827 Positive_regulation TNF MMP1 24552146 295836 Positive_regulation TNF MMP1 24552146 295841 Positive_regulation TNF MMP1 24762063 401008 Positive_regulation TNF MMP1 25356505 1132680 Positive_regulation TNF MMP1 PMC3301273 660921 Positive_regulation TNF MMP10 11237387 418341 Positive_regulation TNF MMP10 14979937 100140 Positive_regulation TNF MMP10 19281072 1071644 Positive_regulation TNF MMP10 19435506 113237 Positive_regulation TNF MMP10 19706153 3109755 Positive_regulation TNF MMP10 20126546 2439093 Positive_regulation TNF MMP10 20126546 2439138 Positive_regulation TNF MMP10 21217769 12304 Positive_regulation TNF MMP10 24762063 401009 Positive_regulation TNF MMP10 25356505 1132681 Positive_regulation TNF MMP11 14979937 100141 Positive_regulation TNF MMP11 19281072 1071645 Positive_regulation TNF MMP11 19435506 113238 Positive_regulation TNF MMP11 19706153 3109756 Positive_regulation TNF MMP11 20126546 2439094 Positive_regulation TNF MMP11 20126546 2439139 Positive_regulation TNF MMP11 21217769 12305 Positive_regulation TNF MMP11 22190977 633856 Positive_regulation TNF MMP11 24762063 401010 Positive_regulation TNF MMP11 25356505 1132682 Positive_regulation TNF MMP12 14979937 100142 Positive_regulation TNF MMP12 19281072 1071646 Positive_regulation TNF MMP12 19435506 113239 Positive_regulation TNF MMP12 19706153 3109757 Positive_regulation TNF MMP12 20126546 2439095 Positive_regulation TNF MMP12 20126546 2439140 Positive_regulation TNF MMP12 21217769 12306 Positive_regulation TNF MMP12 23285156 2732683 Positive_regulation TNF MMP12 23450717 960886 Positive_regulation TNF MMP12 24762063 401011 Positive_regulation TNF MMP12 25356505 1132683 Positive_regulation TNF MMP13 14979937 100143 Positive_regulation TNF MMP13 19281072 1071647 Positive_regulation TNF MMP13 19435506 113240 Positive_regulation TNF MMP13 19706153 3109758 Positive_regulation TNF MMP13 20126546 2439096 Positive_regulation TNF MMP13 20126546 2439141 Positive_regulation TNF MMP13 21217769 12307 Positive_regulation TNF MMP13 23723167 780896 Positive_regulation TNF MMP13 23723167 780897 Positive_regulation TNF MMP13 23723167 780898 Positive_regulation TNF MMP13 23723167 780899 Positive_regulation TNF MMP13 23723167 780904 Positive_regulation TNF MMP13 23723167 780907 Positive_regulation TNF MMP13 23723167 780910 Positive_regulation TNF MMP13 24762063 401012 Positive_regulation TNF MMP13 25356505 1132684 Positive_regulation TNF MMP14 14979937 100144 Positive_regulation TNF MMP14 19279689 1909016 Positive_regulation TNF MMP14 19281072 1071648 Positive_regulation TNF MMP14 19435506 113241 Positive_regulation TNF MMP14 19706153 3109759 Positive_regulation TNF MMP14 20126546 2439097 Positive_regulation TNF MMP14 20126546 2439142 Positive_regulation TNF MMP14 20368140 1031104 Positive_regulation TNF MMP14 21217769 12308 Positive_regulation TNF MMP14 24762063 401013 Positive_regulation TNF MMP14 25356505 1132685 Positive_regulation TNF MMP15 14979937 100145 Positive_regulation TNF MMP15 19281072 1071649 Positive_regulation TNF MMP15 19435506 113242 Positive_regulation TNF MMP15 19706153 3109760 Positive_regulation TNF MMP15 20126546 2439098 Positive_regulation TNF MMP15 20126546 2439143 Positive_regulation TNF MMP15 21217769 12309 Positive_regulation TNF MMP15 24762063 401014 Positive_regulation TNF MMP15 25356505 1132686 Positive_regulation TNF MMP16 14979937 100146 Positive_regulation TNF MMP16 19281072 1071650 Positive_regulation TNF MMP16 19435506 113243 Positive_regulation TNF MMP16 19706153 3109761 Positive_regulation TNF MMP16 20126546 2439099 Positive_regulation TNF MMP16 20126546 2439144 Positive_regulation TNF MMP16 21217769 12310 Positive_regulation TNF MMP16 24762063 401015 Positive_regulation TNF MMP16 25356505 1132687 Positive_regulation TNF MMP17 14979937 100147 Positive_regulation TNF MMP17 19281072 1071651 Positive_regulation TNF MMP17 19435506 113244 Positive_regulation TNF MMP17 19706153 3109762 Positive_regulation TNF MMP17 20126546 2439100 Positive_regulation TNF MMP17 20126546 2439145 Positive_regulation TNF MMP17 20368140 1031105 Positive_regulation TNF MMP17 21217769 12311 Positive_regulation TNF MMP17 24762063 401016 Positive_regulation TNF MMP17 25356505 1132688 Positive_regulation TNF MMP19 14979937 100148 Positive_regulation TNF MMP19 19281072 1071652 Positive_regulation TNF MMP19 19435506 113245 Positive_regulation TNF MMP19 19706153 3109763 Positive_regulation TNF MMP19 20126546 2439101 Positive_regulation TNF MMP19 20126546 2439146 Positive_regulation TNF MMP19 21217769 12312 Positive_regulation TNF MMP19 24762063 401017 Positive_regulation TNF MMP19 25356505 1132689 Positive_regulation TNF MMP2 12516548 2001293 Positive_regulation TNF MMP2 14979937 100149 Positive_regulation TNF MMP2 19281072 1071653 Positive_regulation TNF MMP2 19435506 113246 Positive_regulation TNF MMP2 19706153 3109764 Positive_regulation TNF MMP2 20126546 2439102 Positive_regulation TNF MMP2 20126546 2439147 Positive_regulation TNF MMP2 21217769 12313 Positive_regulation TNF MMP2 21573233 2523003 Positive_regulation TNF MMP2 21573233 2523012 Positive_regulation TNF MMP2 21867555 1659593 Positive_regulation TNF MMP2 22899878 1750201 Positive_regulation TNF MMP2 24552146 295816 Positive_regulation TNF MMP2 24762063 401018 Positive_regulation TNF MMP2 25356505 1132690 Positive_regulation TNF MMP2 PMC4288337 1623776 Positive_regulation TNF MMP20 14979937 100150 Positive_regulation TNF MMP20 19281072 1071654 Positive_regulation TNF MMP20 19435506 113247 Positive_regulation TNF MMP20 19706153 3109765 Positive_regulation TNF MMP20 20126546 2439103 Positive_regulation TNF MMP20 20126546 2439148 Positive_regulation TNF MMP20 21217769 12314 Positive_regulation TNF MMP20 24762063 401019 Positive_regulation TNF MMP20 25356505 1132691 Positive_regulation TNF MMP21 14979937 100137 Positive_regulation TNF MMP21 19281072 1071640 Positive_regulation TNF MMP21 19435506 113234 Positive_regulation TNF MMP21 19706153 3109752 Positive_regulation TNF MMP21 20126546 2439090 Positive_regulation TNF MMP21 20126546 2439135 Positive_regulation TNF MMP21 21217769 12301 Positive_regulation TNF MMP21 24762063 401006 Positive_regulation TNF MMP21 25356505 1132676 Positive_regulation TNF MMP24 14979937 100151 Positive_regulation TNF MMP24 19281072 1071655 Positive_regulation TNF MMP24 19435506 113248 Positive_regulation TNF MMP24 19706153 3109766 Positive_regulation TNF MMP24 20126546 2439104 Positive_regulation TNF MMP24 20126546 2439149 Positive_regulation TNF MMP24 21217769 12315 Positive_regulation TNF MMP24 24762063 401020 Positive_regulation TNF MMP24 25356505 1132692 Positive_regulation TNF MMP25 14979937 100134 Positive_regulation TNF MMP25 19281072 1071637 Positive_regulation TNF MMP25 19435506 113231 Positive_regulation TNF MMP25 19706153 3109749 Positive_regulation TNF MMP25 20126546 2439087 Positive_regulation TNF MMP25 20126546 2439132 Positive_regulation TNF MMP25 21217769 12298 Positive_regulation TNF MMP25 24762063 401003 Positive_regulation TNF MMP25 25356505 1132673 Positive_regulation TNF MMP26 14979937 100135 Positive_regulation TNF MMP26 19281072 1071638 Positive_regulation TNF MMP26 19435506 113232 Positive_regulation TNF MMP26 19706153 3109750 Positive_regulation TNF MMP26 20126546 2439088 Positive_regulation TNF MMP26 20126546 2439133 Positive_regulation TNF MMP26 21217769 12299 Positive_regulation TNF MMP26 24762063 401004 Positive_regulation TNF MMP26 25356505 1132674 Positive_regulation TNF MMP27 14979937 100136 Positive_regulation TNF MMP27 19281072 1071639 Positive_regulation TNF MMP27 19435506 113233 Positive_regulation TNF MMP27 19706153 3109751 Positive_regulation TNF MMP27 20126546 2439089 Positive_regulation TNF MMP27 20126546 2439134 Positive_regulation TNF MMP27 21217769 12300 Positive_regulation TNF MMP27 24762063 401005 Positive_regulation TNF MMP27 25356505 1132675 Positive_regulation TNF MMP28 14979937 100138 Positive_regulation TNF MMP28 19281072 1071641 Positive_regulation TNF MMP28 19435506 113235 Positive_regulation TNF MMP28 19706153 3109753 Positive_regulation TNF MMP28 20126546 2439091 Positive_regulation TNF MMP28 20126546 2439136 Positive_regulation TNF MMP28 21217769 12302 Positive_regulation TNF MMP28 24762063 401007 Positive_regulation TNF MMP28 25356505 1132677 Positive_regulation TNF MMP3 11132772 1737225 Positive_regulation TNF MMP3 14979937 100152 Positive_regulation TNF MMP3 19281072 1071656 Positive_regulation TNF MMP3 19435506 113249 Positive_regulation TNF MMP3 19706153 3109767 Positive_regulation TNF MMP3 20126546 2439105 Positive_regulation TNF MMP3 20126546 2439150 Positive_regulation TNF MMP3 21217769 12316 Positive_regulation TNF MMP3 22360425 810 Positive_regulation TNF MMP3 22899878 1750219 Positive_regulation TNF MMP3 23072510 127025 Positive_regulation TNF MMP3 24116286 204332 Positive_regulation TNF MMP3 24552146 295828 Positive_regulation TNF MMP3 24762063 401021 Positive_regulation TNF MMP3 25356505 1132693 Positive_regulation TNF MMP7 14979937 100153 Positive_regulation TNF MMP7 19281072 1071657 Positive_regulation TNF MMP7 19435506 113250 Positive_regulation TNF MMP7 19706153 3109768 Positive_regulation TNF MMP7 20126546 2439106 Positive_regulation TNF MMP7 20126546 2439151 Positive_regulation TNF MMP7 20368140 1031106 Positive_regulation TNF MMP7 21217769 12317 Positive_regulation TNF MMP7 24762063 401022 Positive_regulation TNF MMP7 24777237 1675570 Positive_regulation TNF MMP7 25356505 1132694 Positive_regulation TNF MMP8 14979937 100154 Positive_regulation TNF MMP8 19281072 1071658 Positive_regulation TNF MMP8 19435506 113251 Positive_regulation TNF MMP8 19706153 3109769 Positive_regulation TNF MMP8 20126546 2439107 Positive_regulation TNF MMP8 20126546 2439152 Positive_regulation TNF MMP8 21217769 12318 Positive_regulation TNF MMP8 23839109 1879623 Positive_regulation TNF MMP8 24762063 401023 Positive_regulation TNF MMP8 25356505 1132695 Positive_regulation TNF MMP9 11132772 1737226 Positive_regulation TNF MMP9 11132772 1737231 Positive_regulation TNF MMP9 11686853 389894 Positive_regulation TNF MMP9 12061424 1738144 Positive_regulation TNF MMP9 12516548 2001294 Positive_regulation TNF MMP9 14979937 100155 Positive_regulation TNF MMP9 14979937 100180 Positive_regulation TNF MMP9 15693944 996179 Positive_regulation TNF MMP9 19281072 1071659 Positive_regulation TNF MMP9 19281093 1071723 Positive_regulation TNF MMP9 19435506 113252 Positive_regulation TNF MMP9 19706153 3109770 Positive_regulation TNF MMP9 20126546 2439108 Positive_regulation TNF MMP9 20126546 2439153 Positive_regulation TNF MMP9 20862369 1747963 Positive_regulation TNF MMP9 21067565 397479 Positive_regulation TNF MMP9 21217769 12319 Positive_regulation TNF MMP9 21320340 259170 Positive_regulation TNF MMP9 21867555 1659535 Positive_regulation TNF MMP9 21867555 1659587 Positive_regulation TNF MMP9 22069489 2569149 Positive_regulation TNF MMP9 22069489 2569157 Positive_regulation TNF MMP9 22069489 2569225 Positive_regulation TNF MMP9 22355243 1914011 Positive_regulation TNF MMP9 22363757 2601797 Positive_regulation TNF MMP9 22761606 3075865 Positive_regulation TNF MMP9 22899878 1750202 Positive_regulation TNF MMP9 23072510 127026 Positive_regulation TNF MMP9 23533637 2770941 Positive_regulation TNF MMP9 23570271 1836555 Positive_regulation TNF MMP9 23587438 1666162 Positive_regulation TNF MMP9 24498087 2918568 Positive_regulation TNF MMP9 24502696 1232952 Positive_regulation TNF MMP9 24502696 1232953 Positive_regulation TNF MMP9 24502696 1232954 Positive_regulation TNF MMP9 24502696 1232955 Positive_regulation TNF MMP9 24502696 1232956 Positive_regulation TNF MMP9 24502696 1232957 Positive_regulation TNF MMP9 24502696 1232958 Positive_regulation TNF MMP9 24502696 1232959 Positive_regulation TNF MMP9 24502696 1233022 Positive_regulation TNF MMP9 24502696 1233059 Positive_regulation TNF MMP9 24502696 1233099 Positive_regulation TNF MMP9 24502696 1233100 Positive_regulation TNF MMP9 24502696 1233101 Positive_regulation TNF MMP9 24502696 1233146 Positive_regulation TNF MMP9 24502696 1233187 Positive_regulation TNF MMP9 24502696 1233188 Positive_regulation TNF MMP9 24502696 1233289 Positive_regulation TNF MMP9 24502696 1233318 Positive_regulation TNF MMP9 24502696 1233319 Positive_regulation TNF MMP9 24502696 1233351 Positive_regulation TNF MMP9 24502696 1233363 Positive_regulation TNF MMP9 24502696 1233364 Positive_regulation TNF MMP9 24552146 295817 Positive_regulation TNF MMP9 24552146 295829 Positive_regulation TNF MMP9 24713998 504022 Positive_regulation TNF MMP9 24762063 401024 Positive_regulation TNF MMP9 24885494 396632 Positive_regulation TNF MMP9 25356505 1132696 Positive_regulation TNF MMP9 25426024 872203 Positive_regulation TNF MOK 19292913 1695978 Positive_regulation TNF MOK 20672051 512983 Positive_regulation TNF MOK 20827421 513001 Positive_regulation TNF MOK 21749686 123204 Positive_regulation TNF MOK 23658798 2790286 Positive_regulation TNF MOK 23894457 2824794 Positive_regulation TNF MOK 24102034 1082930 Positive_regulation TNF MOK 24625976 572988 Positive_regulation TNF MOK 24625976 572989 Positive_regulation TNF MOK 24625976 572990 Positive_regulation TNF MOK 24625976 573001 Positive_regulation TNF MOK 24626220 2933976 Positive_regulation TNF MOK 25025559 1162052 Positive_regulation TNF MPL 24465739 2911594 Positive_regulation TNF MPL 24736547 2953140 Positive_regulation TNF MPO 23285030 2731622 Positive_regulation TNF MPO 9927230 1764329 Positive_regulation TNF MPO 9927230 1764330 Positive_regulation TNF MPO 9927230 1764338 Positive_regulation TNF MPP1 19777175 809849 Positive_regulation TNF MPZ 22624500 1662346 Positive_regulation TNF MPZ 22624500 1662360 Positive_regulation TNF MPZ 22624500 1662361 Positive_regulation TNF MPZ 22624500 1662364 Positive_regulation TNF MPZ 22723850 2654865 Positive_regulation TNF MPZ 22723850 2654888 Positive_regulation TNF MPZ 24069062 822973 Positive_regulation TNF MSC 23936322 2829934 Positive_regulation TNF MSC 24842373 1576401 Positive_regulation TNF MSLN 21880146 1863109 Positive_regulation TNF MSTN 22477519 1238909 Positive_regulation TNF MSTN 23577254 1155655 Positive_regulation TNF MT-CYB 1357073 1528539 Positive_regulation TNF MT-CYB 7836910 1592423 Positive_regulation TNF MT3 12061424 1738140 Positive_regulation TNF MTDH 22768080 2659641 Positive_regulation TNF MTOR 22069489 2569155 Positive_regulation TNF MTOR 22363816 2602085 Positive_regulation TNF MTTP 10815618 1737063 Positive_regulation TNF MTTP 10815618 1737064 Positive_regulation TNF MTTP 10815618 1737065 Positive_regulation TNF MTTP 10815618 1737066 Positive_regulation TNF MTTP 10815618 1737086 Positive_regulation TNF MTX1 24444433 131372 Positive_regulation TNF MUC1 19668469 649368 Positive_regulation TNF MUC1 25147434 1761087 Positive_regulation TNF MUC12 19668469 649369 Positive_regulation TNF MUC12 25147434 1761088 Positive_regulation TNF MUC13 19668469 649370 Positive_regulation TNF MUC13 25147434 1761089 Positive_regulation TNF MUC15 19668469 649362 Positive_regulation TNF MUC15 25147434 1761081 Positive_regulation TNF MUC16 19668469 649363 Positive_regulation TNF MUC16 25147434 1761082 Positive_regulation TNF MUC17 19668469 649364 Positive_regulation TNF MUC17 25147434 1761083 Positive_regulation TNF MUC19 19668469 649361 Positive_regulation TNF MUC19 25147434 1761080 Positive_regulation TNF MUC2 12482999 1633973 Positive_regulation TNF MUC2 19668469 649371 Positive_regulation TNF MUC2 22417007 360731 Positive_regulation TNF MUC2 23723167 780900 Positive_regulation TNF MUC2 25147434 1761090 Positive_regulation TNF MUC20 19668469 649366 Positive_regulation TNF MUC20 25147434 1761085 Positive_regulation TNF MUC21 19668469 649365 Positive_regulation TNF MUC21 25147434 1761084 Positive_regulation TNF MUC22 19668469 649367 Positive_regulation TNF MUC22 25147434 1761086 Positive_regulation TNF MUC4 19668469 649372 Positive_regulation TNF MUC4 25147434 1761091 Positive_regulation TNF MUC5AC 19668469 649354 Positive_regulation TNF MUC6 19668469 649373 Positive_regulation TNF MUC6 25147434 1761092 Positive_regulation TNF MUC7 19668469 649374 Positive_regulation TNF MUC7 25147434 1761093 Positive_regulation TNF MUC8 19668469 649375 Positive_regulation TNF MUC8 25147434 1761094 Positive_regulation TNF MYD88 14517275 1528987 Positive_regulation TNF MYD88 15197227 1532926 Positive_regulation TNF MYD88 15781585 1535157 Positive_regulation TNF MYD88 16304610 3039063 Positive_regulation TNF MYD88 16304610 3039064 Positive_regulation TNF MYD88 18268035 1549141 Positive_regulation TNF MYD88 18617992 3041616 Positive_regulation TNF MYD88 18650365 706635 Positive_regulation TNF MYD88 18947379 111815 Positive_regulation TNF MYD88 19079579 3042863 Positive_regulation TNF MYD88 20497537 362618 Positive_regulation TNF MYD88 20886104 3048848 Positive_regulation TNF MYD88 20939898 353711 Positive_regulation TNF MYD88 20978536 1731824 Positive_regulation TNF MYD88 21049294 665226 Positive_regulation TNF MYD88 21115688 1562060 Positive_regulation TNF MYD88 21283748 2497638 Positive_regulation TNF MYD88 21625574 3051932 Positive_regulation TNF MYD88 21625574 3051934 Positive_regulation TNF MYD88 21789039 979901 Positive_regulation TNF MYD88 22523644 1680640 Positive_regulation TNF MYD88 22701453 901650 Positive_regulation TNF MYD88 23349802 2743316 Positive_regulation TNF MYD88 23469025 2760686 Positive_regulation TNF MYD88 24205328 2876036 Positive_regulation TNF MYD88 24285369 3138845 Positive_regulation TNF MYD88 24288685 185460 Positive_regulation TNF MYD88 24340123 2372311 Positive_regulation TNF MYD88 24349012 2896601 Positive_regulation TNF MYD88 24391507 3065935 Positive_regulation TNF MYD88 24400890 1482473 Positive_regulation TNF MYD88 24489660 2915581 Positive_regulation TNF MYD88 24535292 1087125 Positive_regulation TNF MYD88 24595131 2930817 Positive_regulation TNF MYD88 24605113 911450 Positive_regulation TNF MYD88 24758719 1483080 Positive_regulation TNF MYD88 24904418 954500 Positive_regulation TNF MYD88 24904838 865250 Positive_regulation TNF MYD88 25101851 2995933 Positive_regulation TNF MYD88 25238061 3008348 Positive_regulation TNF MYD88 25514406 1135722 Positive_regulation TNF MYD88 25550115 1734398 Positive_regulation TNF MYLIP 19701459 2424376 Positive_regulation TNF MYLIP 21494372 1037872 Positive_regulation TNF MYLIP 21572107 2063121 Positive_regulation TNF MYLIP 21611196 2523849 Positive_regulation TNF MYLIP 21611196 2523861 Positive_regulation TNF MYLIP 21747943 2534753 Positive_regulation TNF MYLIP 21962237 354708 Positive_regulation TNF MYLIP 22010574 1143111 Positive_regulation TNF MYLIP 22048267 737007 Positive_regulation TNF MYLIP 22518321 1079153 Positive_regulation TNF MYLIP 22518321 1079157 Positive_regulation TNF MYLIP 22536485 139670 Positive_regulation TNF MYLIP 22709905 1663500 Positive_regulation TNF MYLIP 22723921 2655071 Positive_regulation TNF MYLIP 22900099 2675237 Positive_regulation TNF MYLIP 22950459 1665001 Positive_regulation TNF MYLIP 22950459 1665002 Positive_regulation TNF MYLIP 22950459 1665006 Positive_regulation TNF MYLIP 22950459 1665010 Positive_regulation TNF MYLIP 23028373 2338481 Positive_regulation TNF MYLIP 23056947 1145797 Positive_regulation TNF MYLIP 23056947 1145807 Positive_regulation TNF MYLIP 23233675 1205867 Positive_regulation TNF MYLIP 23233675 1205868 Positive_regulation TNF MYLIP 23437179 2755935 Positive_regulation TNF MYLIP 23441172 2756961 Positive_regulation TNF MYLIP 23448104 1231970 Positive_regulation TNF MYLIP 23448136 245395 Positive_regulation TNF MYLIP 23448136 245396 Positive_regulation TNF MYLIP 23448136 245408 Positive_regulation TNF MYLIP 23448136 245425 Positive_regulation TNF MYLIP 23448136 245438 Positive_regulation TNF MYLIP 23506673 1036584 Positive_regulation TNF MYLIP 23603793 1958852 Positive_regulation TNF MYLIP 23638011 2786967 Positive_regulation TNF MYLIP 23638011 2786991 Positive_regulation TNF MYLIP 23733368 780924 Positive_regulation TNF MYLIP 23852016 1108372 Positive_regulation TNF MYLIP 23979021 611324 Positive_regulation TNF MYLIP 23979021 611330 Positive_regulation TNF MYLIP 24023678 2843311 Positive_regulation TNF MYLIP 24098322 2855795 Positive_regulation TNF MYLIP 24349514 2898384 Positive_regulation TNF MYLIP 24351865 1122521 Positive_regulation TNF MYLIP 24351865 1122542 Positive_regulation TNF MYLIP 24400890 1482490 Positive_regulation TNF MYLIP 24475180 2915171 Positive_regulation TNF MYLIP 24475180 2915173 Positive_regulation TNF MYLIP 24475180 2915174 Positive_regulation TNF MYLIP 24475180 2915177 Positive_regulation TNF MYLIP 24499489 346697 Positive_regulation TNF MYLIP 24885472 1701849 Positive_regulation TNF MYLIP 24885472 1701859 Positive_regulation TNF MYLIP 24885472 1701860 Positive_regulation TNF MYLIP 24885472 1701861 Positive_regulation TNF MYLIP 24885472 1701862 Positive_regulation TNF MYLIP 24885472 1701871 Positive_regulation TNF MYLIP 24885472 1701876 Positive_regulation TNF MYLIP 24971753 2985093 Positive_regulation TNF MYLIP 25203514 3006377 Positive_regulation TNF MYLK 20453870 9927 Positive_regulation TNF MYLK 22228679 777062 Positive_regulation TNF MYLK 22228679 777064 Positive_regulation TNF MYLK 23964209 921904 Positive_regulation TNF NA 18369465 3041039 Positive_regulation TNF NA 18986521 1625136 Positive_regulation TNF NAALADL1 16417648 459577 Positive_regulation TNF NAALADL1 17485511 1545735 Positive_regulation TNF NAALADL1 18195076 1548704 Positive_regulation TNF NAALADL1 22206014 2584270 Positive_regulation TNF NAALADL1 22319556 2595420 Positive_regulation TNF NAALADL1 22319556 2595421 Positive_regulation TNF NAALADL1 22319556 2595422 Positive_regulation TNF NAALADL1 22319556 2595425 Positive_regulation TNF NAALADL1 23097717 1152857 Positive_regulation TNF NAALADL1 23398903 1725487 Positive_regulation TNF NAALADL1 23398903 1725492 Positive_regulation TNF NAALADL1 23638101 2787699 Positive_regulation TNF NAALADL1 23667422 2790452 Positive_regulation TNF NAALADL1 24349012 2896566 Positive_regulation TNF NAALADL1 24491080 1627711 Positive_regulation TNF NAALADL1 24580770 1627837 Positive_regulation TNF NAALADL1 25295753 3012772 Positive_regulation TNF NAMPT 18714344 2395662 Positive_regulation TNF NAMPT 20546557 3118938 Positive_regulation TNF NAMPT 22490786 1661487 Positive_regulation TNF NAMPT 22910888 1750235 Positive_regulation TNF NAMPT 23198120 1615782 Positive_regulation TNF NAMPT 23229270 1734765 Positive_regulation TNF NAMPT 23476106 1751693 Positive_regulation TNF NAMPT 23634778 809387 Positive_regulation TNF NAMPT 24757680 189538 Positive_regulation TNF NAMPT 24799765 1758401 Positive_regulation TNF NAMPT 24891763 1759430 Positive_regulation TNF NANOS2 22545173 2371262 Positive_regulation TNF NAP1L4 24728339 2951814 Positive_regulation TNF NCF1 23434665 1102015 Positive_regulation TNF NCF1 23671702 2792516 Positive_regulation TNF NCF1 24212830 499065 Positive_regulation TNF NCF2 23593351 2780757 Positive_regulation TNF NCOA3 24918060 853933 Positive_regulation TNF NCOA3 24918060 853934 Positive_regulation TNF NCR1 22457623 3055889 Positive_regulation TNF NCR1 22457623 3055890 Positive_regulation TNF NCR1 22457623 3055891 Positive_regulation TNF NCR1 22457623 3055893 Positive_regulation TNF NCR1 22457623 3055894 Positive_regulation TNF NCR1 22457623 3055895 Positive_regulation TNF NCR1 22457623 3055897 Positive_regulation TNF NCR1 24516120 1575041 Positive_regulation TNF NCR1 25294115 1736250 Positive_regulation TNF NCR2 24744763 912251 Positive_regulation TNF NCR2 25061260 1760237 Positive_regulation TNF NCR3 23802087 2162591 Positive_regulation TNF NDOR1 24966471 1759843 Positive_regulation TNF NELFCD 20018088 395457 Positive_regulation TNF NELFCD 20836885 1620525 Positive_regulation TNF NELFCD 22470449 2614196 Positive_regulation TNF NELFCD 22572815 1630794 Positive_regulation TNF NELFCD 23259133 515839 Positive_regulation TNF NELFCD 23991146 2841164 Positive_regulation TNF NELFCD 24637903 2934970 Positive_regulation TNF NELFCD PMC3920362 3102774 Positive_regulation TNF NEU1 25187624 761546 Positive_regulation TNF NEU2 25187624 761547 Positive_regulation TNF NEU3 25187624 761548 Positive_regulation TNF NEU4 25187624 761545 Positive_regulation TNF NFAT5 16027109 2016909 Positive_regulation TNF NFAT5 16027109 2016913 Positive_regulation TNF NFAT5 23514422 1683652 Positive_regulation TNF NFATC2 10952728 1516718 Positive_regulation TNF NFATC2 10952728 1516719 Positive_regulation TNF NFATC2 12361922 791230 Positive_regulation TNF NFATC2 23110116 2706451 Positive_regulation TNF NFATC2 24348789 843942 Positive_regulation TNF NFATC2 7650486 1591372 Positive_regulation TNF NFKB1 10815618 1737067 Positive_regulation TNF NFKB1 11097212 702118 Positive_regulation TNF NFKB1 12003644 312732 Positive_regulation TNF NFKB1 12003644 312740 Positive_regulation TNF NFKB1 12885154 702334 Positive_regulation TNF NFKB1 1314883 1528386 Positive_regulation TNF NFKB1 1314883 1528390 Positive_regulation TNF NFKB1 14760934 1739213 Positive_regulation TNF NFKB1 15285796 1654699 Positive_regulation TNF NFKB1 1744583 1545254 Positive_regulation TNF NFKB1 18078008 3208458 Positive_regulation TNF NFKB1 18472824 1741852 Positive_regulation TNF NFKB1 18822146 161136 Positive_regulation TNF NFKB1 18822146 161152 Positive_regulation TNF NFKB1 20126546 2439154 Positive_regulation TNF NFKB1 20145703 1213509 Positive_regulation TNF NFKB1 20178593 362437 Positive_regulation TNF NFKB1 20386714 3046568 Positive_regulation TNF NFKB1 2056282 1558477 Positive_regulation TNF NFKB1 2056282 1558478 Positive_regulation TNF NFKB1 2056282 1558495 Positive_regulation TNF NFKB1 21152121 1081467 Positive_regulation TNF NFKB1 21324111 121497 Positive_regulation TNF NFKB1 21810263 1659147 Positive_regulation TNF NFKB1 2193097 1565454 Positive_regulation TNF NFKB1 21984950 2561244 Positive_regulation TNF NFKB1 22284131 1021099 Positive_regulation TNF NFKB1 22570532 1224130 Positive_regulation TNF NFKB1 22649586 3808 Positive_regulation TNF NFKB1 22654792 875811 Positive_regulation TNF NFKB1 22720084 2654433 Positive_regulation TNF NFKB1 22768337 2660828 Positive_regulation TNF NFKB1 22912686 2678515 Positive_regulation TNF NFKB1 23028204 1750612 Positive_regulation TNF NFKB1 23066908 509349 Positive_regulation TNF NFKB1 23381555 1140587 Positive_regulation TNF NFKB1 23493408 1623978 Positive_regulation TNF NFKB1 23593011 2345164 Positive_regulation TNF NFKB1 23617783 268278 Positive_regulation TNF NFKB1 23651618 3085072 Positive_regulation TNF NFKB1 23724247 1150632 Positive_regulation TNF NFKB1 24400890 1482474 Positive_regulation TNF NFKB1 24740421 2954830 Positive_regulation TNF NFKB1 24772065 869143 Positive_regulation TNF NFKB1 24885472 1701877 Positive_regulation TNF NFKB1 25615645 3038613 Positive_regulation TNF NFKB1 8027185 1444179 Positive_regulation TNF NFKB1 8027185 1444185 Positive_regulation TNF NFKB1 8691131 1598138 Positive_regulation TNF NFKB1 8691131 1598221 Positive_regulation TNF NFKB1 9841930 1604793 Positive_regulation TNF NFKB1 PMC2750795 450335 Positive_regulation TNF NFKB1 PMC3332443 134776 Positive_regulation TNF NFKB1 PMC4291901 541433 Positive_regulation TNF NFKBIZ 20374638 328756 Positive_regulation TNF NGF 23288991 1915402 Positive_regulation TNF NGF 23459929 935213 Positive_regulation TNF NGF 23672639 1666734 Positive_regulation TNF NGF 24358337 2899569 Positive_regulation TNF NGF 24386191 2902946 Positive_regulation TNF NGF 24627687 1070439 Positive_regulation TNF NIT1 9362527 1602022 Positive_regulation TNF NLN 22046952 3210109 Positive_regulation TNF NLRC4 21533069 3051558 Positive_regulation TNF NLRC4 25232720 2372944 Positive_regulation TNF NLRP12 20416261 3209776 Positive_regulation TNF NLRP3 21533069 3051557 Positive_regulation TNF NLRP3 22529966 2620771 Positive_regulation TNF NLRP3 22531291 1661947 Positive_regulation TNF NLRP3 22558291 2625023 Positive_regulation TNF NLRP3 23010656 795066 Positive_regulation TNF NM 12137244 1738154 Positive_regulation TNF NM 18472833 1742141 Positive_regulation TNF NM 18472868 1742310 Positive_regulation TNF NM 18472952 1743327 Positive_regulation TNF NM 18475441 1743785 Positive_regulation TNF NM 18475582 1744405 Positive_regulation TNF NNAT 18591389 706326 Positive_regulation TNF NOD1 22203860 633906 Positive_regulation TNF NOD1 24107297 2212273 Positive_regulation TNF NOD1 25525300 1763263 Positive_regulation TNF NOD2 19581406 1555364 Positive_regulation TNF NOD2 19581406 1555365 Positive_regulation TNF NOD2 21387014 2506177 Positive_regulation TNF NOD2 22203860 633907 Positive_regulation TNF NOD2 23437331 2756466 Positive_regulation TNF NOD2 24107297 2212274 Positive_regulation TNF NOD2 24498172 2918809 Positive_regulation TNF NOD2 24932916 2980528 Positive_regulation TNF NOD2 25580435 202403 Positive_regulation TNF NOS1 17047310 1212350 Positive_regulation TNF NOS1 21423634 812329 Positive_regulation TNF NOS1 23762128 819939 Positive_regulation TNF NOS1 24086172 1226682 Positive_regulation TNF NOS1 24744897 2251801 Positive_regulation TNF NOS1 7530762 1589953 Positive_regulation TNF NOS2 12172046 1632989 Positive_regulation TNF NOS2 16022734 1036137 Positive_regulation TNF NOS2 17047310 1212351 Positive_regulation TNF NOS2 19008294 1637051 Positive_regulation TNF NOS2 19463182 352904 Positive_regulation TNF NOS2 20037732 1213471 Positive_regulation TNF NOS2 21234362 2232145 Positive_regulation TNF NOS2 22069489 2569158 Positive_regulation TNF NOS2 22069489 2569232 Positive_regulation TNF NOS2 23133749 1028934 Positive_regulation TNF NOS2 23243434 816492 Positive_regulation TNF NOS2 23251037 1751076 Positive_regulation TNF NOS2 23365486 1751363 Positive_regulation TNF NOS2 23762128 819940 Positive_regulation TNF NOS2 23915963 1733934 Positive_regulation TNF NOS2 24392456 1495521 Positive_regulation TNF NOS2 24594628 2929942 Positive_regulation TNF NOS2 24688408 3156204 Positive_regulation TNF NOS2 25143806 206489 Positive_regulation TNF NOS2 7530759 1589783 Positive_regulation TNF NOS2 7530759 1589899 Positive_regulation TNF NOS2 7530759 1589928 Positive_regulation TNF NOS2 7530759 1589941 Positive_regulation TNF NOS2 9670043 1603187 Positive_regulation TNF NOS3 17047310 1212352 Positive_regulation TNF NOS3 19118493 651005 Positive_regulation TNF NOS3 20361002 2214372 Positive_regulation TNF NOS3 23762128 819941 Positive_regulation TNF NOTCH1 21958395 1659837 Positive_regulation TNF NOTCH1 22190977 633807 Positive_regulation TNF NOTCH1 22190977 633876 Positive_regulation TNF NOTCH2 22190977 633808 Positive_regulation TNF NOTCH2 22190977 633846 Positive_regulation TNF NOTCH2 22190977 633865 Positive_regulation TNF NOTCH2 22190977 633877 Positive_regulation TNF NOTCH3 22190977 633809 Positive_regulation TNF NOTCH3 22190977 633878 Positive_regulation TNF NOTCH4 22190977 633810 Positive_regulation TNF NOTCH4 22190977 633857 Positive_regulation TNF NOTCH4 22190977 633879 Positive_regulation TNF NOV 23705987 1699795 Positive_regulation TNF NOV 24722330 2951169 Positive_regulation TNF NOX1 1357073 1528540 Positive_regulation TNF NOX1 17698589 1546801 Positive_regulation TNF NOX1 21602838 12790 Positive_regulation TNF NOX1 22346117 1769037 Positive_regulation TNF NOX1 22530124 2009508 Positive_regulation TNF NOX1 22737658 730388 Positive_regulation TNF NOX1 23103617 16131 Positive_regulation TNF NOX1 23555077 180693 Positive_regulation TNF NOX1 23691105 2794528 Positive_regulation TNF NOX1 24624332 3094229 Positive_regulation TNF NOX3 1357073 1528541 Positive_regulation TNF NOX3 17698589 1546802 Positive_regulation TNF NOX3 22346117 1769038 Positive_regulation TNF NOX3 22530124 2009509 Positive_regulation TNF NOX3 22737658 730389 Positive_regulation TNF NOX3 23555077 180694 Positive_regulation TNF NOX3 23691105 2794529 Positive_regulation TNF NOX3 24624332 3094230 Positive_regulation TNF NOX4 1357073 1528542 Positive_regulation TNF NOX4 17698589 1546803 Positive_regulation TNF NOX4 22346117 1769039 Positive_regulation TNF NOX4 22530124 2009510 Positive_regulation TNF NOX4 22737658 730390 Positive_regulation TNF NOX4 23555077 180695 Positive_regulation TNF NOX4 23691105 2794530 Positive_regulation TNF NOX4 24624332 3094231 Positive_regulation TNF NOX5 1357073 1528538 Positive_regulation TNF NOX5 17698589 1546800 Positive_regulation TNF NOX5 22346117 1769036 Positive_regulation TNF NOX5 22530124 2009507 Positive_regulation TNF NOX5 22737658 730387 Positive_regulation TNF NOX5 23555077 180692 Positive_regulation TNF NOX5 23691105 2794527 Positive_regulation TNF NOX5 24624332 3094228 Positive_regulation TNF NPPA 24369440 1755941 Positive_regulation TNF NPS 20652105 1921016 Positive_regulation TNF NPS 20652105 1921017 Positive_regulation TNF NPS 20652105 1921020 Positive_regulation TNF NPS 20652105 1921021 Positive_regulation TNF NPS 22069606 3182695 Positive_regulation TNF NPS 24307938 4838 Positive_regulation TNF NPS 24658543 2937780 Positive_regulation TNF NPS 24658543 2937798 Positive_regulation TNF NPS 24949448 192690 Positive_regulation TNF NPY 16277701 104855 Positive_regulation TNF NPY 18836554 2397378 Positive_regulation TNF NR0B1 19562033 2420161 Positive_regulation TNF NR0B1 20181058 1625890 Positive_regulation TNF NR0B1 20436227 27215 Positive_regulation TNF NR0B1 22844504 2668450 Positive_regulation TNF NR0B1 23469045 2760792 Positive_regulation TNF NR0B1 23586037 180930 Positive_regulation TNF NR0B1 24194783 823840 Positive_regulation TNF NR0B1 24349609 2227669 Positive_regulation TNF NR0B1 24349609 2227673 Positive_regulation TNF NR0B1 24586391 2924444 Positive_regulation TNF NR0B1 24795796 3180438 Positive_regulation TNF NR0B1 24830946 2970418 Positive_regulation TNF NR0B1 25110521 1025873 Positive_regulation TNF NR0B1 25276218 826961 Positive_regulation TNF NR0B1 25276218 826965 Positive_regulation TNF NR0B1 25337584 1241769 Positive_regulation TNF NRAS 22175014 1686850 Positive_regulation TNF NRAS 22908325 1568735 Positive_regulation TNF NRD1 22351606 778186 Positive_regulation TNF NRIP1 22388040 1956616 Positive_regulation TNF NRP1 23365490 1751426 Positive_regulation TNF NTF4 2056282 1558481 Positive_regulation TNF NUP153 21637744 2525852 Positive_regulation TNF NUP210 21637744 2525849 Positive_regulation TNF NUP214 21637744 2525853 Positive_regulation TNF NUP43 11781369 1522161 Positive_regulation TNF NUP43 16581537 792560 Positive_regulation TNF NUP62 21637744 2525854 Positive_regulation TNF OCLN 21853060 2542972 Positive_regulation TNF OCLN 25132736 1760505 Positive_regulation TNF OLFM4 22471589 1230544 Positive_regulation TNF OLR1 25598757 1064867 Positive_regulation TNF OMP 23720712 864035 Positive_regulation TNF OPA1 18410682 110410 Positive_regulation TNF OPA1 20454616 2449463 Positive_regulation TNF OPA1 22691272 126187 Positive_regulation TNF OPA1 PMC2799006 1146793 Positive_regulation TNF OPTN 19096531 1908636 Positive_regulation TNF OPTN 20436471 1948936 Positive_regulation TNF OPTN 22675546 2649099 Positive_regulation TNF OPTN 22675546 2649103 Positive_regulation TNF OSBPL3 22648407 1203400 Positive_regulation TNF OSCAR 23146195 127231 Positive_regulation TNF OTC 24426777 1916733 Positive_regulation TNF OXA1L 17183656 2373749 Positive_regulation TNF OXA1L 8391001 1448085 Positive_regulation TNF P2RX7 17367517 1624951 Positive_regulation TNF P2RX7 17367517 1624964 Positive_regulation TNF P2RX7 18404420 3087117 Positive_regulation TNF P2RX7 18404444 3087451 Positive_regulation TNF P2RX7 21631954 1658514 Positive_regulation TNF P2RX7 22513224 1661883 Positive_regulation TNF P2RX7 22513224 1661886 Positive_regulation TNF P2RX7 24146541 1916407 Positive_regulation TNF P2RY1 18404425 3087174 Positive_regulation TNF P2RY12 24191147 867704 Positive_regulation TNF P2RY6 25360548 3020838 Positive_regulation TNF P4HB 10562323 1513185 Positive_regulation TNF P4HB 18680601 658968 Positive_regulation TNF P4HB 18680601 658973 Positive_regulation TNF P4HB 24381640 825035 Positive_regulation TNF P4HB 9348317 1601934 Positive_regulation TNF PADI4 20222985 481501 Positive_regulation TNF PAEP 16569263 105667 Positive_regulation TNF PAEP 24088372 2233547 Positive_regulation TNF PAEP 24751903 2956153 Positive_regulation TNF PAEP 24799891 980929 Positive_regulation TNF PAF1 1460427 1529592 Positive_regulation TNF PAF1 1460427 1529599 Positive_regulation TNF PAF1 1460427 1529604 Positive_regulation TNF PAF1 1460427 1529609 Positive_regulation TNF PAF1 16172262 1537887 Positive_regulation TNF PAF1 18472926 1743169 Positive_regulation TNF PAF1 19308689 495300 Positive_regulation TNF PAF1 19652714 2422678 Positive_regulation TNF PAF1 21082032 2482394 Positive_regulation TNF PAF1 21860543 1749375 Positive_regulation TNF PAF1 3119758 1580165 Positive_regulation TNF PAF1 7516414 1589296 Positive_regulation TNF PAF1 9836496 1764028 Positive_regulation TNF PAM 18195069 1548430 Positive_regulation TNF PAM 19753301 2426483 Positive_regulation TNF PAM 19966777 1960922 Positive_regulation TNF PAM 20051129 3110244 Positive_regulation TNF PAM 20846396 353603 Positive_regulation TNF PAM 21085613 3049984 Positive_regulation TNF PAM 21124967 2484828 Positive_regulation TNF PAM 21931706 2554188 Positive_regulation TNF PAM 22299046 2594218 Positive_regulation TNF PAM 22355383 2597443 Positive_regulation TNF PAM 22556042 1050669 Positive_regulation TNF PAM 22745844 2371437 Positive_regulation TNF PAM 22997500 3153884 Positive_regulation TNF PAM 23028609 2691911 Positive_regulation TNF PAM 23284793 2730995 Positive_regulation TNF PAM 24205328 2875949 Positive_regulation TNF PAM 24205328 2875988 Positive_regulation TNF PAM 24205328 2875989 Positive_regulation TNF PAM 24205328 2876014 Positive_regulation TNF PAM 24205328 2876015 Positive_regulation TNF PAM 24205328 2876064 Positive_regulation TNF PAM 24205328 2876073 Positive_regulation TNF PAM 24349012 2896569 Positive_regulation TNF PAM 24349012 2896602 Positive_regulation TNF PAM 24349012 2896603 Positive_regulation TNF PAM 24489933 2916960 Positive_regulation TNF PAM 24567720 953585 Positive_regulation TNF PAM 24743542 2955600 Positive_regulation TNF PAM 25057505 1622504 Positive_regulation TNF PAM 25057505 1622543 Positive_regulation TNF PAM 25531754 3035275 Positive_regulation TNF PAPSS1 24078816 638640 Positive_regulation TNF PAPSS1 24672735 3151537 Positive_regulation TNF PARK2 21124909 2484563 Positive_regulation TNF PARK2 22523581 2620387 Positive_regulation TNF PARK2 22523581 2620426 Positive_regulation TNF PARK2 22925731 357271 Positive_regulation TNF PARK2 9599720 797852 Positive_regulation TNF PARK2 9599720 797853 Positive_regulation TNF PARK2 9599720 797854 Positive_regulation TNF PARK2 9599720 797857 Positive_regulation TNF PARK7 21124909 2484562 Positive_regulation TNF PARK7 22523581 2620383 Positive_regulation TNF PARK7 22523581 2620423 Positive_regulation TNF PARK7 22925731 357270 Positive_regulation TNF PARK7 24963279 842111 Positive_regulation TNF PARK7 9599720 797849 Positive_regulation TNF PARK7 9599720 797850 Positive_regulation TNF PARK7 9599720 797851 Positive_regulation TNF PARK7 9599720 797856 Positive_regulation TNF PARP1 20157531 25501 Positive_regulation TNF PARP1 23760205 605931 Positive_regulation TNF PARP1 24444146 1482616 Positive_regulation TNF PARP1 25161822 452501 Positive_regulation TNF PARP1 25161822 452505 Positive_regulation TNF PARP1 25221900 3190741 Positive_regulation TNF PARP10 20157531 25496 Positive_regulation TNF PARP11 20157531 25493 Positive_regulation TNF PARP12 20157531 25494 Positive_regulation TNF PARP14 20157531 25505 Positive_regulation TNF PARP15 20157531 25499 Positive_regulation TNF PARP16 20157531 25497 Positive_regulation TNF PARP2 20157531 25503 Positive_regulation TNF PARP3 20157531 25504 Positive_regulation TNF PARP4 20157531 25502 Positive_regulation TNF PARP6 20157531 25500 Positive_regulation TNF PARP8 20157531 25498 Positive_regulation TNF PARP9 20157531 25495 Positive_regulation TNF PAX8 19935705 2128335 Positive_regulation TNF PC 18560532 793026 Positive_regulation TNF PC 23099484 795107 Positive_regulation TNF PC 23099484 795113 Positive_regulation TNF PCSK1 21853090 2543204 Positive_regulation TNF PCSK1 22037414 1927897 Positive_regulation TNF PCSK1 22037414 1927898 Positive_regulation TNF PCSK1 25443631 762670 Positive_regulation TNF PDB1 2677211 1577810 Positive_regulation TNF PDCD1 8046331 1593789 Positive_regulation TNF PDCD10 8046331 1593790 Positive_regulation TNF PDCD11 8046331 1593788 Positive_regulation TNF PDCD2 8046331 1593791 Positive_regulation TNF PDCD4 8046331 1593792 Positive_regulation TNF PDCD5 8046331 1593793 Positive_regulation TNF PDCD6 8046331 1593794 Positive_regulation TNF PDCD7 8046331 1593795 Positive_regulation TNF PDE3A 18475493 1744047 Positive_regulation TNF PDE3B 18475493 1744048 Positive_regulation TNF PDLIM7 16104828 2368423 Positive_regulation TNF PDLIM7 16573838 33381 Positive_regulation TNF PDLIM7 24886620 3216279 Positive_regulation TNF PECAM1 17242961 810071 Positive_regulation TNF PECAM1 21872249 139261 Positive_regulation TNF PECAM1 23398879 3210482 Positive_regulation TNF PGC 23050972 89638 Positive_regulation TNF PGC 25367151 133800 Positive_regulation TNF PGF 19223981 1746475 Positive_regulation TNF PGF 20500895 285165 Positive_regulation TNF PGP 24130926 204545 Positive_regulation TNF PHLDA1 23686369 1157639 Positive_regulation TNF PHOSPHO1 24826069 1916998 Positive_regulation TNF PHOSPHO2 24826069 1916999 Positive_regulation TNF PI3 20148136 1625874 Positive_regulation TNF PI3 21943198 1697771 Positive_regulation TNF PI3 25132732 1760494 Positive_regulation TNF PIK3C3 24710474 618099 Positive_regulation TNF PIK3CA 11219394 98363 Positive_regulation TNF PIK3CA 11879539 98556 Positive_regulation TNF PIK3CA 11879539 98614 Positive_regulation TNF PIK3CA 12110137 99183 Positive_regulation TNF PIK3CA 18446192 2387893 Positive_regulation TNF PIK3CA 20011115 3045897 Positive_regulation TNF PIK3CA 22606294 2642914 Positive_regulation TNF PIK3CA 22606294 2642915 Positive_regulation TNF PIK3CA 22606294 2643004 Positive_regulation TNF PIK3CA 23514422 1683653 Positive_regulation TNF PIK3CA 23585721 841766 Positive_regulation TNF PIK3CA 23921460 3217751 Positive_regulation TNF PIK3R1 11219394 98364 Positive_regulation TNF PIK3R1 11879539 98557 Positive_regulation TNF PIK3R1 11879539 98615 Positive_regulation TNF PIK3R1 12110137 99184 Positive_regulation TNF PIK3R1 18446192 2387894 Positive_regulation TNF PIK3R1 20011115 3045898 Positive_regulation TNF PIK3R1 22606294 2642916 Positive_regulation TNF PIK3R1 22606294 2642917 Positive_regulation TNF PIK3R1 22606294 2643005 Positive_regulation TNF PIK3R1 23514422 1683654 Positive_regulation TNF PIK3R1 23585721 841767 Positive_regulation TNF PIK3R1 23921460 3217752 Positive_regulation TNF PINK1 21124909 2484561 Positive_regulation TNF PINK1 22523581 2620382 Positive_regulation TNF PINK1 22523581 2620422 Positive_regulation TNF PINK1 22925731 357269 Positive_regulation TNF PINK1 9599720 797846 Positive_regulation TNF PINK1 9599720 797847 Positive_regulation TNF PINK1 9599720 797848 Positive_regulation TNF PINK1 9599720 797855 Positive_regulation TNF PLA2G1B 14613529 3095444 Positive_regulation TNF PLA2G1B 1658188 1539858 Positive_regulation TNF PLA2G1B 19500354 1722826 Positive_regulation TNF PLA2G1B 23509747 180075 Positive_regulation TNF PLA2G1B 23509747 180076 Positive_regulation TNF PLA2G1B 23509754 180086 Positive_regulation TNF PLA2G1B 8760826 1598973 Positive_regulation TNF PLA2G1B PMC1968561 448069 Positive_regulation TNF PLA2G4A 22832605 3189138 Positive_regulation TNF PLA2G4A 24069158 2851334 Positive_regulation TNF PLA2G4A 24069158 2851335 Positive_regulation TNF PLA2G4A 24069158 2851336 Positive_regulation TNF PLA2G4A 24069158 2851357 Positive_regulation TNF PLA2G4A 24069158 2851516 Positive_regulation TNF PLA2G4A 24069158 2851517 Positive_regulation TNF PLA2G4A 24069158 2851642 Positive_regulation TNF PLA2G4A 24349530 2898415 Positive_regulation TNF PLA2G4A 24616552 1757583 Positive_regulation TNF PLA2G4A 24776599 514447 Positive_regulation TNF PLA2G4A 8027185 1444192 Positive_regulation TNF PLA2G4A 9400742 797596 Positive_regulation TNF PLAA 2258694 1568151 Positive_regulation TNF PLAA 2499653 1577005 Positive_regulation TNF PLAU 1714936 1543582 Positive_regulation TNF PLAU 22662010 95285 Positive_regulation TNF PLAU 24120085 1667185 Positive_regulation TNF PLAU 8826848 445614 Positive_regulation TNF PLAU 9764576 447919 Positive_regulation TNF PLAUR 23840908 2818823 Positive_regulation TNF PLD1 25047119 2990880 Positive_regulation TNF PLEC 24499192 367811 Positive_regulation TNF PLG 1714936 1543583 Positive_regulation TNF PLG 18057520 736041 Positive_regulation TNF PLG 8601593 1450659 Positive_regulation TNF PLIN1 23499576 3204081 Positive_regulation TNF PLIN1 23781214 878838 Positive_regulation TNF PLK1 24205328 2875950 Positive_regulation TNF PLK1 24205328 2875973 Positive_regulation TNF PLK1 24205328 2875974 Positive_regulation TNF PLK1 24205328 2875975 Positive_regulation TNF PLK1 24205328 2875990 Positive_regulation TNF PLK1 24205328 2876016 Positive_regulation TNF PLK1 24205328 2876017 Positive_regulation TNF PLK1 24205328 2876037 Positive_regulation TNF PLK1 24205328 2876065 Positive_regulation TNF PLK1 24205328 2876066 Positive_regulation TNF PLK1 24489933 2916923 Positive_regulation TNF PLK2 24489933 2916920 Positive_regulation TNF PLK3 24489933 2916921 Positive_regulation TNF PLK4 24489933 2916918 Positive_regulation TNF PLK5 24489933 2916922 Positive_regulation TNF PLN 19956717 2432597 Positive_regulation TNF PLN 19956717 2432601 Positive_regulation TNF PLXNA4 21098092 1561607 Positive_regulation TNF PLXNA4 21098092 1561608 Positive_regulation TNF POLDIP2 14960183 656416 Positive_regulation TNF POLDIP2 16542479 105132 Positive_regulation TNF POLDIP2 22069638 3182917 Positive_regulation TNF POLDIP2 22069639 3182962 Positive_regulation TNF POLDIP2 23557259 3215459 Positive_regulation TNF POLDIP2 24307884 3155507 Positive_regulation TNF POLDIP2 24423080 538852 Positive_regulation TNF POLDIP2 24446489 1574661 Positive_regulation TNF POLDIP2 9529323 1602587 Positive_regulation TNF POLG2 15289505 1533212 Positive_regulation TNF POLR2A 21298084 2320985 Positive_regulation TNF POLR2B 21298084 2320986 Positive_regulation TNF POLR2C 21298084 2320987 Positive_regulation TNF POLR2D 21298084 2320988 Positive_regulation TNF POLR2E 21298084 2320989 Positive_regulation TNF POLR2F 21298084 2320990 Positive_regulation TNF POLR2G 21298084 2320991 Positive_regulation TNF POLR2H 21298084 2320992 Positive_regulation TNF POLR2I 21298084 2320993 Positive_regulation TNF POLR2J 21298084 2320994 Positive_regulation TNF POLR2K 21298084 2320995 Positive_regulation TNF POLR2L 21298084 2320996 Positive_regulation TNF PPA1 21854591 1723870 Positive_regulation TNF PPA2 21854591 1723869 Positive_regulation TNF PPARA 18315837 1670757 Positive_regulation TNF PPARA 22537532 1662209 Positive_regulation TNF PPARA 22537532 1662219 Positive_regulation TNF PPARA 22537532 1662220 Positive_regulation TNF PPP3CA 21298033 2499356 Positive_regulation TNF PPP3CA 24883060 1074229 Positive_regulation TNF PPP3CA 7650486 1591364 Positive_regulation TNF PPP3CA 8046352 1593848 Positive_regulation TNF PPP3CA 8046352 1593849 Positive_regulation TNF PPP3CA 8046352 1593863 Positive_regulation TNF PPP3CA 8046352 1593866 Positive_regulation TNF PPP3CB 21298033 2499357 Positive_regulation TNF PPP3CB 8046352 1593867 Positive_regulation TNF PPP3CC 21298033 2499358 Positive_regulation TNF PPP3CC 8046352 1593868 Positive_regulation TNF PPP3R1 24883060 1074230 Positive_regulation TNF PPP3R1 7650486 1591365 Positive_regulation TNF PPP3R1 8046352 1593850 Positive_regulation TNF PPP3R1 8046352 1593851 Positive_regulation TNF PPP3R1 8046352 1593864 Positive_regulation TNF PQBP1 22355401 2597496 Positive_regulation TNF PRDM1 23087693 904780 Positive_regulation TNF PRDM2 24832654 177022 Positive_regulation TNF PRDX2 22314197 834279 Positive_regulation TNF PRDX2 24039666 2844388 Positive_regulation TNF PRDX3 20716930 2222668 Positive_regulation TNF PRKAA1 23300870 2736882 Positive_regulation TNF PRKAA1 23300870 2736912 Positive_regulation TNF PRKAA2 23300870 2736883 Positive_regulation TNF PRKAA2 23300870 2736913 Positive_regulation TNF PRKAB1 23300870 2736884 Positive_regulation TNF PRKAB1 23300870 2736914 Positive_regulation TNF PRKAB2 23300870 2736885 Positive_regulation TNF PRKAB2 23300870 2736915 Positive_regulation TNF PRKACB 18568240 652510 Positive_regulation TNF PRKACB 18568240 652609 Positive_regulation TNF PRKACB 19277197 2407718 Positive_regulation TNF PRKACB 22384111 2604052 Positive_regulation TNF PRKACB 22384111 2605931 Positive_regulation TNF PRKACB 2549168 1577339 Positive_regulation TNF PRKACB 2549168 1577340 Positive_regulation TNF PRKACB 2549168 1577352 Positive_regulation TNF PRKACG 18568240 652511 Positive_regulation TNF PRKACG 18568240 652610 Positive_regulation TNF PRKACG 19277197 2407719 Positive_regulation TNF PRKACG 22384111 2604053 Positive_regulation TNF PRKACG 22384111 2605932 Positive_regulation TNF PRKACG 2549168 1577341 Positive_regulation TNF PRKACG 2549168 1577342 Positive_regulation TNF PRKACG 2549168 1577353 Positive_regulation TNF PRKAG1 23300870 2736886 Positive_regulation TNF PRKAG1 23300870 2736916 Positive_regulation TNF PRKAG2 23300870 2736887 Positive_regulation TNF PRKAG2 23300870 2736917 Positive_regulation TNF PRKAR1A 18568240 652512 Positive_regulation TNF PRKAR1A 18568240 652611 Positive_regulation TNF PRKAR1A 19277197 2407720 Positive_regulation TNF PRKAR1A 22384111 2604054 Positive_regulation TNF PRKAR1A 22384111 2605933 Positive_regulation TNF PRKAR1A 2549168 1577343 Positive_regulation TNF PRKAR1A 2549168 1577344 Positive_regulation TNF PRKAR1A 2549168 1577354 Positive_regulation TNF PRKAR1B 18568240 652513 Positive_regulation TNF PRKAR1B 18568240 652612 Positive_regulation TNF PRKAR1B 19277197 2407721 Positive_regulation TNF PRKAR1B 22384111 2604055 Positive_regulation TNF PRKAR1B 22384111 2605934 Positive_regulation TNF PRKAR1B 2549168 1577345 Positive_regulation TNF PRKAR1B 2549168 1577346 Positive_regulation TNF PRKAR1B 2549168 1577355 Positive_regulation TNF PRKAR2A 18568240 652514 Positive_regulation TNF PRKAR2A 18568240 652613 Positive_regulation TNF PRKAR2A 19277197 2407722 Positive_regulation TNF PRKAR2A 22384111 2604056 Positive_regulation TNF PRKAR2A 22384111 2605935 Positive_regulation TNF PRKAR2A 2549168 1577347 Positive_regulation TNF PRKAR2A 2549168 1577348 Positive_regulation TNF PRKAR2A 2549168 1577356 Positive_regulation TNF PRKAR2B 18568240 652515 Positive_regulation TNF PRKAR2B 18568240 652614 Positive_regulation TNF PRKAR2B 19277197 2407723 Positive_regulation TNF PRKAR2B 22384111 2604057 Positive_regulation TNF PRKAR2B 22384111 2605936 Positive_regulation TNF PRKAR2B 2549168 1577349 Positive_regulation TNF PRKAR2B 2549168 1577350 Positive_regulation TNF PRKAR2B 2549168 1577357 Positive_regulation TNF PRKCD 17570844 233044 Positive_regulation TNF PRKD1 23665907 1106584 Positive_regulation TNF PRL 14638848 1529839 Positive_regulation TNF PRL 23731754 1626999 Positive_regulation TNF PRNP 22292032 2592033 Positive_regulation TNF PRNP 22531291 1662095 Positive_regulation TNF PRNP 24952384 1668266 Positive_regulation TNF PRNP 24952384 1668268 Positive_regulation TNF PRNP 24952384 1668269 Positive_regulation TNF PRNP 24952384 1668271 Positive_regulation TNF PROK1 24051059 3102698 Positive_regulation TNF PRPH 11604419 1275711 Positive_regulation TNF PRR11 19721713 2425570 Positive_regulation TNF PRR12 19721713 2425576 Positive_regulation TNF PRR13 19721713 2425569 Positive_regulation TNF PRR14 19721713 2425574 Positive_regulation TNF PRR15 19721713 2425568 Positive_regulation TNF PRR16 19721713 2425577 Positive_regulation TNF PRR18 19721713 2425575 Positive_regulation TNF PRR19 19721713 2425581 Positive_regulation TNF PRR21 19721713 2425582 Positive_regulation TNF PRR22 19721713 2425573 Positive_regulation TNF PRR24 19721713 2425571 Positive_regulation TNF PRR25 19721713 2425583 Positive_regulation TNF PRR26 19721713 2425578 Positive_regulation TNF PRR3 19721713 2425567 Positive_regulation TNF PRR4 19721713 2425566 Positive_regulation TNF PRR5 19721713 2425579 Positive_regulation TNF PRR7 19721713 2425572 Positive_regulation TNF PRR9 19721713 2425580 Positive_regulation TNF PSIP1 19814828 3212919 Positive_regulation TNF PSIP1 22883744 1664697 Positive_regulation TNF PSIP1 22883744 1664701 Positive_regulation TNF PSIP1 22883744 1664717 Positive_regulation TNF PSIP1 22883744 1664754 Positive_regulation TNF PTBP1 11304549 1519274 Positive_regulation TNF PTBP1 11828008 1522833 Positive_regulation TNF PTBP1 12437786 1733976 Positive_regulation TNF PTBP1 15197227 1532949 Positive_regulation TNF PTBP1 16847068 1541177 Positive_regulation TNF PTBP1 16847068 1541185 Positive_regulation TNF PTBP1 18369465 3041037 Positive_regulation TNF PTBP1 18466643 110692 Positive_regulation TNF PTBP1 20182538 1746931 Positive_regulation TNF PTBP1 20574522 2453447 Positive_regulation TNF PTBP1 21194488 354233 Positive_regulation TNF PTBP1 21274433 632268 Positive_regulation TNF PTBP1 21527026 649077 Positive_regulation TNF PTBP1 22007224 1086039 Positive_regulation TNF PTBP1 22235359 2371164 Positive_regulation TNF PTBP1 22363214 3055730 Positive_regulation TNF PTBP1 22523644 1680585 Positive_regulation TNF PTBP1 22563430 2626501 Positive_regulation TNF PTBP1 24039775 2844763 Positive_regulation TNF PTBP1 24094416 1041419 Positive_regulation TNF PTBP1 24365457 367449 Positive_regulation TNF PTBP1 24782985 947739 Positive_regulation TNF PTBP1 25057505 1622544 Positive_regulation TNF PTBP1 25071777 913393 Positive_regulation TNF PTBP1 25111185 2996189 Positive_regulation TNF PTBP1 7561684 1590652 Positive_regulation TNF PTBP1 9670049 1603221 Positive_regulation TNF PTBP2 11304549 1519271 Positive_regulation TNF PTBP2 11828008 1522830 Positive_regulation TNF PTBP2 12437786 1733973 Positive_regulation TNF PTBP2 15197227 1532946 Positive_regulation TNF PTBP2 16847068 1541174 Positive_regulation TNF PTBP2 16847068 1541182 Positive_regulation TNF PTBP2 18369465 3041034 Positive_regulation TNF PTBP2 18466643 110688 Positive_regulation TNF PTBP2 20182538 1746928 Positive_regulation TNF PTBP2 20574522 2453444 Positive_regulation TNF PTBP2 21194488 354230 Positive_regulation TNF PTBP2 21274433 632264 Positive_regulation TNF PTBP2 21527026 649074 Positive_regulation TNF PTBP2 22007224 1086036 Positive_regulation TNF PTBP2 22235359 2371161 Positive_regulation TNF PTBP2 22363214 3055727 Positive_regulation TNF PTBP2 22523644 1680582 Positive_regulation TNF PTBP2 22563430 2626498 Positive_regulation TNF PTBP2 24039775 2844760 Positive_regulation TNF PTBP2 24094416 1041416 Positive_regulation TNF PTBP2 24365457 367446 Positive_regulation TNF PTBP2 24782985 947736 Positive_regulation TNF PTBP2 25057505 1622539 Positive_regulation TNF PTBP2 25071777 913390 Positive_regulation TNF PTBP2 25111185 2996186 Positive_regulation TNF PTBP2 7561684 1590649 Positive_regulation TNF PTBP2 9670049 1603218 Positive_regulation TNF PTGS2 11806848 3103647 Positive_regulation TNF PTGS2 14627219 1049557 Positive_regulation TNF PTGS2 15266333 424821 Positive_regulation TNF PTGS2 15285796 1654700 Positive_regulation TNF PTGS2 18274606 831117 Positive_regulation TNF PTGS2 19196878 3102637 Positive_regulation TNF PTGS2 19531212 253522 Positive_regulation TNF PTGS2 20976153 2479070 Positive_regulation TNF PTGS2 21234362 2232146 Positive_regulation TNF PTGS2 22034110 735015 Positive_regulation TNF PTGS2 22832605 3189139 Positive_regulation TNF PTGS2 24351869 1122545 Positive_regulation TNF PTGS2 25383223 1083593 Positive_regulation TNF PTGS2 9547339 1602653 Positive_regulation TNF PTH 20808842 2472739 Positive_regulation TNF PTH 20808842 2472740 Positive_regulation TNF PTHLH 20953899 645850 Positive_regulation TNF PTK2 21042558 1912076 Positive_regulation TNF PTK6 21042558 1912077 Positive_regulation TNF PTK7 21042558 1912078 Positive_regulation TNF PTP4A3 24885636 273409 Positive_regulation TNF PTP4A3 24885636 273420 Positive_regulation TNF PTP4A3 24885636 273421 Positive_regulation TNF PTPN1 24349514 2898388 Positive_regulation TNF PTPN11 23555760 2775251 Positive_regulation TNF PTPN7 24265715 2885013 Positive_regulation TNF PTPN7 24265715 2885014 Positive_regulation TNF PTPN7 24265715 2885015 Positive_regulation TNF PTPRC 11094451 98197 Positive_regulation TNF PTPRC 11879539 98616 Positive_regulation TNF PTS 24265715 2885057 Positive_regulation TNF PTX3 18568240 652615 Positive_regulation TNF PTX3 22529962 2620731 Positive_regulation TNF PTX3 22577258 1749982 Positive_regulation TNF PTX3 23401658 1915580 Positive_regulation TNF PTX3 23755050 907385 Positive_regulation TNF PTX3 23755050 907392 Positive_regulation TNF PTX3 23755050 907421 Positive_regulation TNF PTX4 18568240 652608 Positive_regulation TNF PTX4 23755050 907384 Positive_regulation TNF PXN 23674089 440634 Positive_regulation TNF PXN 7525604 1436342 Positive_regulation TNF QSOX1 19093006 1908630 Positive_regulation TNF QSOX2 19093006 1908629 Positive_regulation TNF RAB11A 22894638 1664809 Positive_regulation TNF RAB6A 23437303 2756410 Positive_regulation TNF RAB6A 23437303 2756411 Positive_regulation TNF RAB8A 7544395 1590491 Positive_regulation TNF RAB8A 8642259 1596418 Positive_regulation TNF RABEPK 15813981 1624712 Positive_regulation TNF RABEPK 23700396 1039651 Positive_regulation TNF RAC1 23389627 1811756 Positive_regulation TNF RAC2 23389627 1811757 Positive_regulation TNF RAC3 23389627 1811758 Positive_regulation TNF RAD23B 7519620 1436159 Positive_regulation TNF RAD23B 7519620 1436171 Positive_regulation TNF RAE1 24098802 2864942 Positive_regulation TNF RAF1 18282094 3040905 Positive_regulation TNF RAF1 18282094 3040981 Positive_regulation TNF RANBP2 21637744 2525855 Positive_regulation TNF RASSF1 24327924 1831667 Positive_regulation TNF RASSF1 24776599 514460 Positive_regulation TNF RASSF1 24776599 514529 Positive_regulation TNF RBBP4 15899037 103370 Positive_regulation TNF RBBP4 21234331 1218423 Positive_regulation TNF RBBP4 7931061 1593045 Positive_regulation TNF RBBP7 15899037 103371 Positive_regulation TNF RBBP7 21234331 1218424 Positive_regulation TNF RBBP7 7931061 1593046 Positive_regulation TNF RBCK1 23104095 1958259 Positive_regulation TNF RBCK1 23104095 1958310 Positive_regulation TNF RBM10 21799736 2538401 Positive_regulation TNF RBM5 20652022 2456174 Positive_regulation TNF RBP4 19675137 710818 Positive_regulation TNF RBP4 19675137 710825 Positive_regulation TNF RBP4 19675137 710826 Positive_regulation TNF RBP4 19675137 710829 Positive_regulation TNF RBP4 19675137 710831 Positive_regulation TNF RBP4 22272381 1082516 Positive_regulation TNF REG3A 24587207 2929047 Positive_regulation TNF REL 16191192 318560 Positive_regulation TNF REL 16191192 318596 Positive_regulation TNF REL 21912593 2552133 Positive_regulation TNF REL 22547990 3152615 Positive_regulation TNF RELA 10815618 1737068 Positive_regulation TNF RELA 11044363 418026 Positive_regulation TNF RELA 11097212 702119 Positive_regulation TNF RELA 12003644 312733 Positive_regulation TNF RELA 12003644 312741 Positive_regulation TNF RELA 12885154 702335 Positive_regulation TNF RELA 1314883 1528387 Positive_regulation TNF RELA 1314883 1528391 Positive_regulation TNF RELA 14760934 1739214 Positive_regulation TNF RELA 15285796 1654701 Positive_regulation TNF RELA 16191192 318597 Positive_regulation TNF RELA 1744583 1545255 Positive_regulation TNF RELA 18078008 3208459 Positive_regulation TNF RELA 18472824 1741853 Positive_regulation TNF RELA 18822146 161137 Positive_regulation TNF RELA 18822146 161153 Positive_regulation TNF RELA 19132086 3042914 Positive_regulation TNF RELA 20126546 2439155 Positive_regulation TNF RELA 20145703 1213510 Positive_regulation TNF RELA 20178593 362438 Positive_regulation TNF RELA 20386714 3046569 Positive_regulation TNF RELA 2056282 1558479 Positive_regulation TNF RELA 2056282 1558480 Positive_regulation TNF RELA 2056282 1558496 Positive_regulation TNF RELA 20844082 1782657 Positive_regulation TNF RELA 21138578 1626275 Positive_regulation TNF RELA 21152121 1081468 Positive_regulation TNF RELA 21298084 2320997 Positive_regulation TNF RELA 21324111 121498 Positive_regulation TNF RELA 21706061 2140616 Positive_regulation TNF RELA 21765477 2141247 Positive_regulation TNF RELA 21810263 1659148 Positive_regulation TNF RELA 2193097 1565455 Positive_regulation TNF RELA 21984950 2561245 Positive_regulation TNF RELA 22284131 1021100 Positive_regulation TNF RELA 22570532 1224131 Positive_regulation TNF RELA 22649586 3809 Positive_regulation TNF RELA 22654792 875812 Positive_regulation TNF RELA 22720084 2654434 Positive_regulation TNF RELA 22768337 2660829 Positive_regulation TNF RELA 22768337 2660832 Positive_regulation TNF RELA 22912686 2678516 Positive_regulation TNF RELA 22996371 1029316 Positive_regulation TNF RELA 22996371 1029319 Positive_regulation TNF RELA 23028204 1750613 Positive_regulation TNF RELA 23066908 509350 Positive_regulation TNF RELA 23381555 1140588 Positive_regulation TNF RELA 23528859 1103281 Positive_regulation TNF RELA 23593011 2345165 Positive_regulation TNF RELA 23617783 268279 Positive_regulation TNF RELA 23651618 3085073 Positive_regulation TNF RELA 23724247 1150633 Positive_regulation TNF RELA 24191131 1754987 Positive_regulation TNF RELA 24191131 1754996 Positive_regulation TNF RELA 24400890 1482475 Positive_regulation TNF RELA 24740421 2954831 Positive_regulation TNF RELA 24772065 869144 Positive_regulation TNF RELA 24885472 1701878 Positive_regulation TNF RELA 24957606 2102192 Positive_regulation TNF RELA 24957606 2102195 Positive_regulation TNF RELA 25615645 3038614 Positive_regulation TNF RELA 8027185 1444180 Positive_regulation TNF RELA 8027185 1444186 Positive_regulation TNF RELA 8691131 1598139 Positive_regulation TNF RELA 8691131 1598222 Positive_regulation TNF RELA 9841930 1604794 Positive_regulation TNF RELA PMC2750795 450336 Positive_regulation TNF RELA PMC3332443 134777 Positive_regulation TNF RELA PMC4291901 541434 Positive_regulation TNF RELB 21310030 354377 Positive_regulation TNF RELB PMC2834068 134557 Positive_regulation TNF RENBP 15203568 1739643 Positive_regulation TNF RENBP 15203568 1739655 Positive_regulation TNF RENBP 15203568 1739687 Positive_regulation TNF RENBP 17183656 2373694 Positive_regulation TNF RENBP 19735566 116679 Positive_regulation TNF RENBP 23936610 2226596 Positive_regulation TNF RENBP 24976875 2214731 Positive_regulation TNF RENBP 24976875 2214734 Positive_regulation TNF RENBP 25025559 1162111 Positive_regulation TNF RETN 19125180 1746418 Positive_regulation TNF RETN 19125180 1746423 Positive_regulation TNF RETN 19473519 1227118 Positive_regulation TNF RETN 19473519 1227136 Positive_regulation TNF RETN 19473519 1227140 Positive_regulation TNF RETN 20591185 353471 Positive_regulation TNF RETN 21615949 1626372 Positive_regulation TNF RETN 21615949 1626374 Positive_regulation TNF RETN 21615949 1626376 Positive_regulation TNF RETN 21960997 980061 Positive_regulation TNF RETN 22567283 1139561 Positive_regulation TNF RETN 22577247 1749880 Positive_regulation TNF RETN 22577940 125865 Positive_regulation TNF RETN 22935594 30824 Positive_regulation TNF RETN 23304125 980598 Positive_regulation TNF RETN 24404511 731050 Positive_regulation TNF RETN 24559185 314672 Positive_regulation TNF RETN 24799765 1758382 Positive_regulation TNF REV1 24040434 2372092 Positive_regulation TNF REV1 24040434 2372093 Positive_regulation TNF RHBDF2 25546423 3036579 Positive_regulation TNF RHO 24381507 3155627 Positive_regulation TNF RHOA 21473788 1658076 Positive_regulation TNF RHOA 23389627 1811755 Positive_regulation TNF RHOA 23389627 1811877 Positive_regulation TNF RIPK1 22075985 547605 Positive_regulation TNF RIPK1 23328672 559001 Positive_regulation TNF RIPK1 23328672 559024 Positive_regulation TNF RIPK1 23328672 559036 Positive_regulation TNF RIPK1 24535827 1416576 Positive_regulation TNF RIPK1 24577082 572420 Positive_regulation TNF RIPK2 15280422 1533180 Positive_regulation TNF RIPK2 19360122 3043740 Positive_regulation TNF RIPK2 22203860 633905 Positive_regulation TNF RIPK2 22203860 633933 Positive_regulation TNF RIPK3 21368763 1987125 Positive_regulation TNF RIPK3 22075985 547606 Positive_regulation TNF RIPK3 23328672 559002 Positive_regulation TNF RIPK3 23328672 559025 Positive_regulation TNF RIPK3 23374330 388413 Positive_regulation TNF RIPK3 23760205 605925 Positive_regulation TNF RIPK3 23788031 562992 Positive_regulation TNF RIPK3 24090154 537728 Positive_regulation TNF RIPK3 24535827 1416572 Positive_regulation TNF RIPK3 24909514 18991 Positive_regulation TNF RIPK3 25136567 197164 Positive_regulation TNF RMRP 22787557 3130858 Positive_regulation TNF RNASE1 20089176 284038 Positive_regulation TNF RNASE10 20089176 284044 Positive_regulation TNF RNASE11 20089176 284043 Positive_regulation TNF RNASE12 20089176 284048 Positive_regulation TNF RNASE13 20089176 284049 Positive_regulation TNF RNASE2 20089176 284039 Positive_regulation TNF RNASE3 20089176 284040 Positive_regulation TNF RNASE4 20089176 284041 Positive_regulation TNF RNASE6 20089176 284042 Positive_regulation TNF RNASE7 20089176 284046 Positive_regulation TNF RNASE7 23555696 2774927 Positive_regulation TNF RNASE8 20089176 284045 Positive_regulation TNF RNASE9 20089176 284047 Positive_regulation TNF RNF11 22684508 2075788 Positive_regulation TNF RNF19A 16606437 658647 Positive_regulation TNF RNF19A 19416526 659186 Positive_regulation TNF RNF19A 20011115 3045908 Positive_regulation TNF RNF19A 20513241 3110386 Positive_regulation TNF RNF19A 20644550 10402 Positive_regulation TNF RNF19A 21197399 632178 Positive_regulation TNF RNF19A 21534089 1694167 Positive_regulation TNF RNF19A 21961050 2224114 Positive_regulation TNF RNF19A 21984950 2561243 Positive_regulation TNF RNF19A 21984950 2561256 Positive_regulation TNF RNF19A 22315682 1687057 Positive_regulation TNF RNF19A 23227067 3204580 Positive_regulation TNF RNF19A 23549267 1105015 Positive_regulation TNF RNF19A 23549267 1105253 Positive_regulation TNF RNF19A 23555735 2774999 Positive_regulation TNF RNF19A 23587438 1666560 Positive_regulation TNF RNF19A 23908766 749692 Positive_regulation TNF RNF19A 24421891 2909263 Positive_regulation TNF RNF19A 25025559 1162097 Positive_regulation TNF RNF19A 25025559 1162171 Positive_regulation TNF RNF19A 25180066 2229988 Positive_regulation TNF RNF19A 25295284 1623302 Positive_regulation TNF RNF19A 25435878 1074913 Positive_regulation TNF RPAP1 21298084 2320980 Positive_regulation TNF RPL17 24690491 1667883 Positive_regulation TNF RPL22 24159339 823089 Positive_regulation TNF RPLP1 24663085 1125561 Positive_regulation TNF RPLP1 24663085 1125571 Positive_regulation TNF RPS19 23805193 2807637 Positive_regulation TNF RPS6KA5 24705157 985047 Positive_regulation TNF RPS6KB1 23805409 20480 Positive_regulation TNF RPS6KB1 24116273 204235 Positive_regulation TNF RPS6KB1 24116273 204236 Positive_regulation TNF RPS6KB1 24116273 204237 Positive_regulation TNF RTL1 25409514 3028773 Positive_regulation TNF RUNX2 24594641 2929968 Positive_regulation TNF RUNX3 19139168 1553559 Positive_regulation TNF S100A1 16613612 105728 Positive_regulation TNF S100A12 16864903 1740304 Positive_regulation TNF S100A12 19292913 1695973 Positive_regulation TNF S100A12 20529227 34832 Positive_regulation TNF S100A12 23476696 817474 Positive_regulation TNF S100A12 24884769 2112104 Positive_regulation TNF S100A12 25110868 1128909 Positive_regulation TNF S100A12 25159733 3145295 Positive_regulation TNF S100A12 PMC4184146 2236339 Positive_regulation TNF S100A6 20672023 512973 Positive_regulation TNF S100A8 16613612 105729 Positive_regulation TNF S100A8 19196461 324772 Positive_regulation TNF S100A8 19284577 112942 Positive_regulation TNF S100A8 20964825 855157 Positive_regulation TNF S100A8 23619188 838839 Positive_regulation TNF S100A8 24391503 3065887 Positive_regulation TNF S100A9 16613612 105730 Positive_regulation TNF S100A9 16613612 105856 Positive_regulation TNF S100A9 20964825 855158 Positive_regulation TNF S100A9 23638054 2787388 Positive_regulation TNF S100A9 24391503 3065888 Positive_regulation TNF S100A9 PMC4184146 2236340 Positive_regulation TNF S100B 19292913 1695977 Positive_regulation TNF S100B 19292913 1695983 Positive_regulation TNF S100B 20827421 513000 Positive_regulation TNF S100B 20862385 513133 Positive_regulation TNF S100B 24626220 2933975 Positive_regulation TNF S11 3772296 1583658 Positive_regulation TNF S12 3772296 1583659 Positive_regulation TNF S7 3772296 1583660 Positive_regulation TNF SAA1 16737350 2368809 Positive_regulation TNF SAA1 19043563 1746399 Positive_regulation TNF SAA1 19043563 1746406 Positive_regulation TNF SAA1 21394207 2506566 Positive_regulation TNF SAA1 21986708 1140315 Positive_regulation TNF SAA1 22072820 1713176 Positive_regulation TNF SAA1 23638054 2787332 Positive_regulation TNF SAA1 23638054 2787426 Positive_regulation TNF SAA1 24920450 3224734 Positive_regulation TNF SAA2 21394207 2506567 Positive_regulation TNF SAA2 23840908 2818803 Positive_regulation TNF SAA3P 19513118 2418663 Positive_regulation TNF SAA3P 19513118 2418665 Positive_regulation TNF SAA3P 24694941 1703522 Positive_regulation TNF SAA3P 24694941 1703541 Positive_regulation TNF SAA4 21394207 2506568 Positive_regulation TNF SAG 18685727 1908332 Positive_regulation TNF SAG 18685727 1908335 Positive_regulation TNF SAG 20419140 2447177 Positive_regulation TNF SAG 24205055 2875158 Positive_regulation TNF SAG 24786833 548906 Positive_regulation TNF SAMHD1 24116037 2864998 Positive_regulation TNF SAP130 7931061 1593042 Positive_regulation TNF SAP30 7931061 1593038 Positive_regulation TNF SCG2 23586068 181386 Positive_regulation TNF SCG2 23586068 181431 Positive_regulation TNF SCG3 23586068 181388 Positive_regulation TNF SCG3 23586068 181433 Positive_regulation TNF SCG5 23586068 181387 Positive_regulation TNF SCG5 23586068 181432 Positive_regulation TNF SCN8A 16258197 1740208 Positive_regulation TNF SDC2 16022734 1036136 Positive_regulation TNF SDC4 19093006 1908628 Positive_regulation TNF SEA 16614521 1634724 Positive_regulation TNF SEA 16614521 1634734 Positive_regulation TNF SEA 21931534 2277141 Positive_regulation TNF SEA 2258710 1568224 Positive_regulation TNF SEA 2258710 1568226 Positive_regulation TNF SEA 2258710 1568227 Positive_regulation TNF SEA 2258710 1568228 Positive_regulation TNF SEA 22778626 3158872 Positive_regulation TNF SEA 22778626 3158873 Positive_regulation TNF SEA 23270458 357309 Positive_regulation TNF SEA 23589093 94853 Positive_regulation TNF SEC61B 24821544 1126497 Positive_regulation TNF SELE 1281211 1527735 Positive_regulation TNF SELE 12875662 247415 Positive_regulation TNF SELE 12875662 247419 Positive_regulation TNF SELE 1383376 1528829 Positive_regulation TNF SELE 20181103 1625934 Positive_regulation TNF SELE 21872249 139259 Positive_regulation TNF SELE 23398879 3210480 Positive_regulation TNF SELE 23533479 817803 Positive_regulation TNF SELE 24127491 1573878 Positive_regulation TNF SELE 24228622 359338 Positive_regulation TNF SELE 24228622 359363 Positive_regulation TNF SELE 7683689 1438791 Positive_regulation TNF SELE 7686390 444170 Positive_regulation TNF SELE 7836926 1592547 Positive_regulation TNF SELE 8551244 1595947 Positive_regulation TNF SELE 8691131 1598136 Positive_regulation TNF SELE 9625761 1602980 Positive_regulation TNF SELL 11435478 1519736 Positive_regulation TNF SELL 15225369 101365 Positive_regulation TNF SELL 7705312 796395 Positive_regulation TNF SELP 21264293 2495218 Positive_regulation TNF SELP 23398879 3210481 Positive_regulation TNF SELP 24382971 639433 Positive_regulation TNF SELP 7683689 1438792 Positive_regulation TNF SEMA3A 21098092 1561652 Positive_regulation TNF SEMA6A 21098092 1561653 Positive_regulation TNF SEMA7A 24550834 963537 Positive_regulation TNF SEMA7A 25353180 1132628 Positive_regulation TNF SEPSECS 24206576 357474 Positive_regulation TNF SERPINA3 17822540 395879 Positive_regulation TNF SERPINB3 21858034 2545813 Positive_regulation TNF SERPINE1 19093006 1908625 Positive_regulation TNF SERPINE1 22220265 1764533 Positive_regulation TNF SERPINE1 22462016 1151076 Positive_regulation TNF SERPINE1 22523688 1683316 Positive_regulation TNF SERPINE1 23208413 2110583 Positive_regulation TNF SERPINE1 23785355 878866 Positive_regulation TNF SERPINE1 25276060 1762698 Positive_regulation TNF SERPINE2 22028159 3232850 Positive_regulation TNF SERPINF1 19247457 1909003 Positive_regulation TNF SERPINF1 24367624 2900355 Positive_regulation TNF SERPINF1 24367624 2900367 Positive_regulation TNF SERPINF1 24367624 2900368 Positive_regulation TNF SERPINF1 24367624 2900373 Positive_regulation TNF SERPINF1 24367624 2900374 Positive_regulation TNF SERPINF1 24367624 2900405 Positive_regulation TNF SERPINF1 24367624 2900406 Positive_regulation TNF SETBP1 16144553 312906 Positive_regulation TNF SETBP1 16614521 1634725 Positive_regulation TNF SETBP1 16614521 1634735 Positive_regulation TNF SETBP1 19001139 1552750 Positive_regulation TNF SETBP1 19091080 659102 Positive_regulation TNF SETBP1 19091080 659103 Positive_regulation TNF SETBP1 19091080 659104 Positive_regulation TNF SETBP1 20041187 2435873 Positive_regulation TNF SETBP1 21283748 2497612 Positive_regulation TNF SETBP1 21283748 2497674 Positive_regulation TNF SETBP1 21931534 2277142 Positive_regulation TNF SETBP1 21931534 2277150 Positive_regulation TNF SETBP1 22069676 3183402 Positive_regulation TNF SETBP1 22211167 35701 Positive_regulation TNF SETBP1 22272213 813666 Positive_regulation TNF SETBP1 22272213 813674 Positive_regulation TNF SETBP1 22848400 2668682 Positive_regulation TNF SETBP1 22848400 2668708 Positive_regulation TNF SETBP1 23282714 3225353 Positive_regulation TNF SETBP1 23282714 3225358 Positive_regulation TNF SETBP1 23589093 94850 Positive_regulation TNF SETBP1 24324645 2890959 Positive_regulation TNF SETBP1 24324645 2890968 Positive_regulation TNF SETBP1 24423010 356561 Positive_regulation TNF SETBP1 24533103 2922272 Positive_regulation TNF SETBP1 7520469 1589454 Positive_regulation TNF SETBP1 8760835 1599066 Positive_regulation TNF SETD2 12617740 658459 Positive_regulation TNF SETD2 17029647 1727731 Positive_regulation TNF SETD2 19222864 112790 Positive_regulation TNF SETD2 21298084 2320960 Positive_regulation TNF SETD2 21298084 2320961 Positive_regulation TNF SETD2 21298084 2320974 Positive_regulation TNF SETD2 21298084 2321016 Positive_regulation TNF SETD2 21298084 2321019 Positive_regulation TNF SETD2 22621400 412052 Positive_regulation TNF SETD2 22621400 412055 Positive_regulation TNF SETD2 23029213 2695547 Positive_regulation TNF SETD2 24312355 2888942 Positive_regulation TNF SETD2 24326162 1159016 Positive_regulation TNF SETD2 24662828 2154916 Positive_regulation TNF SETD2 24782866 912404 Positive_regulation TNF SETD2 24879546 1730833 Positive_regulation TNF SETD2 25051011 2991152 Positive_regulation TNF SETD2 25365172 1133735 Positive_regulation TNF SH3BP2 22640988 2221118 Positive_regulation TNF SHARPIN 25443632 762691 Positive_regulation TNF SHARPIN 25443632 762722 Positive_regulation TNF SI 23238232 651943 Positive_regulation TNF SIGLEC7 15996269 1624736 Positive_regulation TNF SIGLEC7 19570027 137290 Positive_regulation TNF SIGLEC7 23029261 2695726 Positive_regulation TNF SIGLEC7 23029261 2695751 Positive_regulation TNF SIGLEC7 8145037 1594242 Positive_regulation TNF SIGLEC7 8627186 1596299 Positive_regulation TNF SIGLEC9 23029261 2695733 Positive_regulation TNF SIL1 24498365 2919256 Positive_regulation TNF SIN3A 7931061 1593040 Positive_regulation TNF SIRT1 22069489 2569147 Positive_regulation TNF SIRT1 22069489 2569148 Positive_regulation TNF SIRT1 22069489 2569229 Positive_regulation TNF SIRT1 22447223 14597 Positive_regulation TNF SIRT1 24039666 2844467 Positive_regulation TNF SIRT2 24039666 2844466 Positive_regulation TNF SIRT3 24039666 2844468 Positive_regulation TNF SIRT4 24039666 2844469 Positive_regulation TNF SIRT5 24039666 2844470 Positive_regulation TNF SIRT6 19936064 2431679 Positive_regulation TNF SIRT6 19936064 2431681 Positive_regulation TNF SIRT6 21738489 2325082 Positive_regulation TNF SIRT6 23016857 692364 Positive_regulation TNF SIRT6 24039666 2844471 Positive_regulation TNF SIRT6 24064057 220791 Positive_regulation TNF SIRT7 24039666 2844472 Positive_regulation TNF SKP1 21559359 2518413 Positive_regulation TNF SLAMF1 15123745 1532267 Positive_regulation TNF SLAMF7 24098802 2864940 Positive_regulation TNF SLAMF7 24098802 2864943 Positive_regulation TNF SLC1A2 24472696 90548 Positive_regulation TNF SLC22A3 15946381 3105058 Positive_regulation TNF SLC22A3 20049734 774452 Positive_regulation TNF SLC22A3 22187661 1082422 Positive_regulation TNF SLC22A3 22315958 469769 Positive_regulation TNF SLC22A3 22938142 358626 Positive_regulation TNF SLC22A3 23300891 2737185 Positive_regulation TNF SLC22A3 23437179 2755910 Positive_regulation TNF SLC22A3 23441172 2756972 Positive_regulation TNF SLC22A3 23935876 2828162 Positive_regulation TNF SLC22A3 24250816 2881727 Positive_regulation TNF SLC22A3 24386633 186136 Positive_regulation TNF SLC25A5 18267033 462073 Positive_regulation TNF SLC33A1 24503248 1685557 Positive_regulation TNF SLC33A1 24979132 1128067 Positive_regulation TNF SLC33A1 25574467 202393 Positive_regulation TNF SLC39A8 23304467 1669943 Positive_regulation TNF SLCO6A1 17567906 370613 Positive_regulation TNF SLCO6A1 22469910 1086625 Positive_regulation TNF SLCO6A1 22469910 1086627 Positive_regulation TNF SLCO6A1 22469910 1086629 Positive_regulation TNF SLCO6A1 22469910 1086632 Positive_regulation TNF SLCO6A1 22469910 1086635 Positive_regulation TNF SLCO6A1 24165011 3123867 Positive_regulation TNF SLCO6A1 24386331 2903487 Positive_regulation TNF SLPI 10449524 1512271 Positive_regulation TNF SLPI 21912612 2552181 Positive_regulation TNF SMAD2 19087346 3109085 Positive_regulation TNF SMAD2 22476871 1238673 Positive_regulation TNF SMAD2 23762086 637609 Positive_regulation TNF SMAD3 22476871 1238674 Positive_regulation TNF SMAD7 18781153 431171 Positive_regulation TNF SMAD7 24791137 1916882 Positive_regulation TNF SMOX 16008840 3105097 Positive_regulation TNF SMPD1 23230083 1637638 Positive_regulation TNF SMPD3 24007266 1667081 Positive_regulation TNF SMURF1 22396737 2608374 Positive_regulation TNF SMURF1 24592264 911262 Positive_regulation TNF SMURF2 22396737 2608375 Positive_regulation TNF SMURF2 24592264 911263 Positive_regulation TNF SNAI1 20049734 774453 Positive_regulation TNF SNAPIN 24387801 1162638 Positive_regulation TNF SNRNP70 16330816 1538747 Positive_regulation TNF SNRPA 16330816 1538748 Positive_regulation TNF SNRPC 16330816 1538749 Positive_regulation TNF SNRPN PMC2834096 134571 Positive_regulation TNF SOAT1 25400510 1628046 Positive_regulation TNF SOCS1 11208867 1518799 Positive_regulation TNF SOCS1 15203568 1739642 Positive_regulation TNF SOCS2 25360135 914876 Positive_regulation TNF SOCS3 19698101 362365 Positive_regulation TNF SOCS3 21242294 1562400 Positive_regulation TNF SOCS3 22500980 355787 Positive_regulation TNF SOCS3 22500980 355788 Positive_regulation TNF SOCS3 23533689 2225618 Positive_regulation TNF SOCS3 23565388 1044371 Positive_regulation TNF SOCS3 25352752 1917437 Positive_regulation TNF SOCS3 25352752 1917438 Positive_regulation TNF SOCS3 25352752 1917470 Positive_regulation TNF SOCS3 25352752 1917501 Positive_regulation TNF SOCS3 25377316 83985 Positive_regulation TNF SOD1 21062492 1657268 Positive_regulation TNF SOD1 22891158 3131105 Positive_regulation TNF SOD2 18588690 361778 Positive_regulation TNF SOD2 22322095 1882588 Positive_regulation TNF SOD2 24885568 365026 Positive_regulation TNF SORT1 21863317 1644767 Positive_regulation TNF SOST 22477520 694249 Positive_regulation TNF SOST 24286133 130357 Positive_regulation TNF SP1 17637837 2377194 Positive_regulation TNF SP100 20236452 659480 Positive_regulation TNF SPAM1 11960552 276621 Positive_regulation TNF SPHK1 10545499 1251526 Positive_regulation TNF SPHK1 20498849 2451125 Positive_regulation TNF SPHK1 20498849 2451126 Positive_regulation TNF SPHK1 20577214 1985433 Positive_regulation TNF SPHK1 21310085 1657770 Positive_regulation TNF SPHK2 10545499 1251527 Positive_regulation TNF SPN 10899905 1516259 Positive_regulation TNF SPN 10899905 1516260 Positive_regulation TNF SPP1 19765294 326374 Positive_regulation TNF SPP1 21345222 121569 Positive_regulation TNF SPP1 22269588 1660767 Positive_regulation TNF SPP1 24871103 2975266 Positive_regulation TNF SPP1 24944898 1888018 Positive_regulation TNF SREBF1 21988829 1723923 Positive_regulation TNF SRF 24386331 2903656 Positive_regulation TNF SRGN 21880179 623903 Positive_regulation TNF SRSF1 24940033 1917090 Positive_regulation TNF SST 25530957 201943 Positive_regulation TNF ST2 20689814 2457835 Positive_regulation TNF ST3GAL4 20587056 1657055 Positive_regulation TNF ST3GAL4 21042558 1912096 Positive_regulation TNF ST3GAL4 24527050 825256 Positive_regulation TNF ST3GAL4 25093030 826574 Positive_regulation TNF ST3GAL4 25501750 3033679 Positive_regulation TNF ST8SIA2 21206910 2491213 Positive_regulation TNF STAT1 20174649 2441592 Positive_regulation TNF STAT1 22096344 1628231 Positive_regulation TNF STAT1 22937039 2682772 Positive_regulation TNF STAT1 23034049 3113191 Positive_regulation TNF STAT1 23071392 1137171 Positive_regulation TNF STAT1 25024400 1637288 Positive_regulation TNF STAT3 19701245 2126397 Positive_regulation TNF STAT3 20205746 1656140 Positive_regulation TNF STAT3 21637744 2525881 Positive_regulation TNF STAT3 21637744 2525959 Positive_regulation TNF STAT3 22558380 2625420 Positive_regulation TNF STAT3 22937006 2682697 Positive_regulation TNF STAT3 23236394 2726129 Positive_regulation TNF STAT3 23236394 2726145 Positive_regulation TNF STAT3 23236394 2726157 Positive_regulation TNF STAT3 23236394 2726158 Positive_regulation TNF STAT3 23236394 2726165 Positive_regulation TNF STAT3 23236394 2726174 Positive_regulation TNF STAT3 23840548 2815140 Positive_regulation TNF STAT3 23942241 1937480 Positive_regulation TNF STAT3 24101903 962399 Positive_regulation TNF STAT3 24244348 2879490 Positive_regulation TNF STAT3 24416411 2908582 Positive_regulation TNF STAT4 10880525 1516048 Positive_regulation TNF STAT6 14638848 1529871 Positive_regulation TNF STEAP4 24643198 1062543 Positive_regulation TNF STIP1 23977369 2840070 Positive_regulation TNF STK10 11238593 1518984 Positive_regulation TNF STK11 11238593 1518985 Positive_regulation TNF STK16 11238593 1518986 Positive_regulation TNF STK19 11238593 1518987 Positive_regulation TNF STK24 11238593 1518988 Positive_regulation TNF STK25 11238593 1518989 Positive_regulation TNF STK3 11238593 1518990 Positive_regulation TNF STK31 11238593 1518991 Positive_regulation TNF STK33 11238593 1518993 Positive_regulation TNF STK35 11238593 1518994 Positive_regulation TNF STK36 11238593 1518995 Positive_regulation TNF STK38 11238593 1518997 Positive_regulation TNF STK39 11238593 1518996 Positive_regulation TNF STK4 11238593 1518992 Positive_regulation TNF STK40 11238593 1518998 Positive_regulation TNF STS 20351692 1953773 Positive_regulation TNF STS 21533069 3051556 Positive_regulation TNF STS 23010656 795064 Positive_regulation TNF STX4 19305493 2408450 Positive_regulation TNF SUDS3 7931061 1593041 Positive_regulation TNF SULT2A1 23062310 856165 Positive_regulation TNF SULT2A1 25032216 194825 Positive_regulation TNF SYK 19703985 1555938 Positive_regulation TNF SYK 22496641 3055981 Positive_regulation TNF SYK 22883599 292352 Positive_regulation TNF SYK 22883599 292353 Positive_regulation TNF SYK 24023637 2843136 Positive_regulation TNF SYK 24340123 2372310 Positive_regulation TNF SYK 24340123 2372322 Positive_regulation TNF SYK 25140116 1761038 Positive_regulation TNF SYN1 17105652 106827 Positive_regulation TNF SYN1 17105652 106828 Positive_regulation TNF SYN1 17105652 106988 Positive_regulation TNF SYN1 23936437 2830435 Positive_regulation TNF SYN2 17105652 106829 Positive_regulation TNF SYN2 17105652 106830 Positive_regulation TNF SYN2 17105652 106989 Positive_regulation TNF SYN2 23936437 2830436 Positive_regulation TNF SYN3 17105652 106831 Positive_regulation TNF SYN3 17105652 106832 Positive_regulation TNF SYN3 17105652 106990 Positive_regulation TNF SYN3 23936437 2830437 Positive_regulation TNF SYNPO 23840712 2816211 Positive_regulation TNF SYT1 11044363 418025 Positive_regulation TNF SYT1 11044363 418041 Positive_regulation TNF SYT1 20195489 26829 Positive_regulation TNF SYT1 21199955 1562318 Positive_regulation TNF SYT1 21765477 2141246 Positive_regulation TNF SYT1 22396737 2608359 Positive_regulation TNF SYT1 22426696 14555 Positive_regulation TNF SYT1 22432006 2611507 Positive_regulation TNF SYT1 22547990 3152611 Positive_regulation TNF SYT1 22701747 2652527 Positive_regulation TNF SYT1 22768286 2660441 Positive_regulation TNF SYT1 23284617 2730268 Positive_regulation TNF SYT1 23710113 1753132 Positive_regulation TNF SYT1 23805228 2807919 Positive_regulation TNF SYT1 23861891 2820555 Positive_regulation TNF SYT1 24141950 1991007 Positive_regulation TNF SYT1 24470523 1159264 Positive_regulation TNF SYT1 24502696 1233033 Positive_regulation TNF SYT1 24864134 1758830 Positive_regulation TNF SYT1 24967365 193110 Positive_regulation TNF TAB1 19307598 1364680 Positive_regulation TNF TAB1 19307598 1364682 Positive_regulation TNF TAB1 22313861 3160943 Positive_regulation TNF TAB1 23331383 1675462 Positive_regulation TNF TAB1 24386633 186125 Positive_regulation TNF TAB1 24911653 152867 Positive_regulation TNF TAB2 23922952 2827748 Positive_regulation TNF TAC1 24586871 2927422 Positive_regulation TNF TAC3 24586871 2927423 Positive_regulation TNF TAC4 24586871 2927424 Positive_regulation TNF TAF1 16191192 318585 Positive_regulation TNF TAF10 16191192 318591 Positive_regulation TNF TAF11 16191192 318592 Positive_regulation TNF TAF12 16191192 318593 Positive_regulation TNF TAF13 16191192 318594 Positive_regulation TNF TAF4 16191192 318586 Positive_regulation TNF TAF4B 16191192 318587 Positive_regulation TNF TAF5 16191192 318588 Positive_regulation TNF TAF6 16191192 318589 Positive_regulation TNF TAF9 16191192 318590 Positive_regulation TNF TANK 10385526 1247214 Positive_regulation TNF TANK 19918265 609866 Positive_regulation TNF TANK 21119000 1783906 Positive_regulation TNF TANK 22570745 1024135 Positive_regulation TNF TANK 24457959 571469 Positive_regulation TNF TANK 24600451 911358 Positive_regulation TNF TANK 8691131 1598137 Positive_regulation TNF TAP2 22883599 292354 Positive_regulation TNF TAP2 22883599 292355 Positive_regulation TNF TAP2 22883599 292356 Positive_regulation TNF TAP2 22883599 292357 Positive_regulation TNF TAP2 22883599 292358 Positive_regulation TNF TAP2 22883599 292362 Positive_regulation TNF TAP2 22883599 292377 Positive_regulation TNF TAP2 22883599 292378 Positive_regulation TNF TAP2 22883599 292383 Positive_regulation TNF TAP2 22883599 292388 Positive_regulation TNF TAP2 22883599 292390 Positive_regulation TNF TAP2 9016879 1599987 Positive_regulation TNF TARS 23425968 3134266 Positive_regulation TNF TAT 17194214 2262316 Positive_regulation TNF TAT 17565699 3116598 Positive_regulation TNF TAT 19116667 2404013 Positive_regulation TNF TAT 19116667 2404016 Positive_regulation TNF TAT 19116667 2404019 Positive_regulation TNF TAT 19116667 2404037 Positive_regulation TNF TAT 19467159 3117920 Positive_regulation TNF TAT 20195780 1654424 Positive_regulation TNF TAT 20195780 1654440 Positive_regulation TNF TAT 22039370 1038377 Positive_regulation TNF TAT 22039370 1038397 Positive_regulation TNF TAT 22591363 680522 Positive_regulation TNF TAT 23190742 1665190 Positive_regulation TNF TAT 23190742 1665200 Positive_regulation TNF TAT 23758766 3121889 Positive_regulation TNF TAT 24165011 3123847 Positive_regulation TNF TAT 24165011 3123848 Positive_regulation TNF TAT 24165011 3123849 Positive_regulation TNF TAT 24165011 3123850 Positive_regulation TNF TAT 24165011 3123863 Positive_regulation TNF TAT 24165011 3123875 Positive_regulation TNF TAT 24165011 3123898 Positive_regulation TNF TAT 24359561 3216134 Positive_regulation TNF TAT 25351961 167599 Positive_regulation TNF TAT PMC3837019 3038930 Positive_regulation TNF TAX1BP1 19609363 3044883 Positive_regulation TNF TBCA 20193086 1897614 Positive_regulation TNF TBCA 22685592 2650423 Positive_regulation TNF TBCA 23469047 2760796 Positive_regulation TNF TBCC 8627186 1596300 Positive_regulation TNF TBCE 22728710 15606 Positive_regulation TNF TBCE 23209806 2723139 Positive_regulation TNF TBK1 21931631 2553718 Positive_regulation TNF TBP 16191192 318595 Positive_regulation TNF TBP 22247597 1490079 Positive_regulation TNF TCEA1 22391038 1396090 Positive_regulation TNF TCF12 11516343 994117 Positive_regulation TNF TCF12 16192667 1740065 Positive_regulation TNF TCF12 19351711 708236 Positive_regulation TNF TCF12 20680494 1654476 Positive_regulation TNF TCF12 21966220 3209134 Positive_regulation TNF TCF12 22054645 1898693 Positive_regulation TNF TCF12 22225778 469601 Positive_regulation TNF TCF12 22479453 2615364 Positive_regulation TNF TCF12 22645700 1082571 Positive_regulation TNF TCF12 22685371 1749988 Positive_regulation TNF TCF12 23125487 1750647 Positive_regulation TNF TCF12 23481064 1045262 Positive_regulation TNF TCF12 23509807 180570 Positive_regulation TNF TCF12 23843781 696916 Positive_regulation TNF TCF12 23864765 1754247 Positive_regulation TNF TCF12 24116272 204212 Positive_regulation TNF TCF12 24591741 1046884 Positive_regulation TNF TCF12 24883060 1074217 Positive_regulation TNF TCF12 25053922 1627958 Positive_regulation TNF TCF12 25175787 396731 Positive_regulation TNF TCF12 25210730 3006555 Positive_regulation TNF TCF12 25215307 1623213 Positive_regulation TNF TCF12 8381117 1447716 Positive_regulation TNF TCF12 8391000 1448060 Positive_regulation TNF TCF12 9400717 797376 Positive_regulation TNF TCF15 11516343 994118 Positive_regulation TNF TCF15 16192667 1740066 Positive_regulation TNF TCF15 19351711 708237 Positive_regulation TNF TCF15 20680494 1654477 Positive_regulation TNF TCF15 21966220 3209135 Positive_regulation TNF TCF15 22054645 1898694 Positive_regulation TNF TCF15 22225778 469602 Positive_regulation TNF TCF15 22479453 2615365 Positive_regulation TNF TCF15 22645700 1082572 Positive_regulation TNF TCF15 22685371 1749989 Positive_regulation TNF TCF15 23125487 1750648 Positive_regulation TNF TCF15 23481064 1045263 Positive_regulation TNF TCF15 23509807 180571 Positive_regulation TNF TCF15 23843781 696917 Positive_regulation TNF TCF15 23864765 1754248 Positive_regulation TNF TCF15 24116272 204213 Positive_regulation TNF TCF15 24591741 1046885 Positive_regulation TNF TCF15 24883060 1074218 Positive_regulation TNF TCF15 25053922 1627959 Positive_regulation TNF TCF15 25175787 396732 Positive_regulation TNF TCF15 25210730 3006556 Positive_regulation TNF TCF15 25215307 1623214 Positive_regulation TNF TCF15 8381117 1447717 Positive_regulation TNF TCF15 8391000 1448061 Positive_regulation TNF TCF15 9400717 797377 Positive_regulation TNF TCF19 11516343 994119 Positive_regulation TNF TCF19 16192667 1740067 Positive_regulation TNF TCF19 19351711 708238 Positive_regulation TNF TCF19 20680494 1654478 Positive_regulation TNF TCF19 21966220 3209136 Positive_regulation TNF TCF19 22054645 1898695 Positive_regulation TNF TCF19 22225778 469603 Positive_regulation TNF TCF19 22479453 2615366 Positive_regulation TNF TCF19 22645700 1082573 Positive_regulation TNF TCF19 22685371 1749990 Positive_regulation TNF TCF19 23125487 1750649 Positive_regulation TNF TCF19 23481064 1045264 Positive_regulation TNF TCF19 23509807 180572 Positive_regulation TNF TCF19 23843781 696918 Positive_regulation TNF TCF19 23864765 1754249 Positive_regulation TNF TCF19 24116272 204214 Positive_regulation TNF TCF19 24591741 1046886 Positive_regulation TNF TCF19 24883060 1074219 Positive_regulation TNF TCF19 25053922 1627960 Positive_regulation TNF TCF19 25175787 396733 Positive_regulation TNF TCF19 25210730 3006557 Positive_regulation TNF TCF19 25215307 1623215 Positive_regulation TNF TCF19 8381117 1447718 Positive_regulation TNF TCF19 8391000 1448062 Positive_regulation TNF TCF19 9400717 797378 Positive_regulation TNF TCF20 11516343 994120 Positive_regulation TNF TCF20 16192667 1740068 Positive_regulation TNF TCF20 19351711 708239 Positive_regulation TNF TCF20 20680494 1654479 Positive_regulation TNF TCF20 21966220 3209137 Positive_regulation TNF TCF20 22054645 1898696 Positive_regulation TNF TCF20 22225778 469604 Positive_regulation TNF TCF20 22479453 2615367 Positive_regulation TNF TCF20 22645700 1082574 Positive_regulation TNF TCF20 22685371 1749991 Positive_regulation TNF TCF20 23125487 1750650 Positive_regulation TNF TCF20 23481064 1045265 Positive_regulation TNF TCF20 23509807 180573 Positive_regulation TNF TCF20 23843781 696919 Positive_regulation TNF TCF20 23864765 1754250 Positive_regulation TNF TCF20 24116272 204215 Positive_regulation TNF TCF20 24591741 1046887 Positive_regulation TNF TCF20 24883060 1074220 Positive_regulation TNF TCF20 25053922 1627961 Positive_regulation TNF TCF20 25175787 396734 Positive_regulation TNF TCF20 25210730 3006558 Positive_regulation TNF TCF20 25215307 1623216 Positive_regulation TNF TCF20 8381117 1447719 Positive_regulation TNF TCF20 8391000 1448063 Positive_regulation TNF TCF20 9400717 797379 Positive_regulation TNF TCF21 11516343 994121 Positive_regulation TNF TCF21 16192667 1740069 Positive_regulation TNF TCF21 19351711 708240 Positive_regulation TNF TCF21 20680494 1654480 Positive_regulation TNF TCF21 21966220 3209138 Positive_regulation TNF TCF21 22054645 1898697 Positive_regulation TNF TCF21 22225778 469605 Positive_regulation TNF TCF21 22479453 2615368 Positive_regulation TNF TCF21 22645700 1082575 Positive_regulation TNF TCF21 22685371 1749992 Positive_regulation TNF TCF21 23125487 1750651 Positive_regulation TNF TCF21 23481064 1045266 Positive_regulation TNF TCF21 23509807 180574 Positive_regulation TNF TCF21 23843781 696920 Positive_regulation TNF TCF21 23864765 1754251 Positive_regulation TNF TCF21 24116272 204216 Positive_regulation TNF TCF21 24591741 1046888 Positive_regulation TNF TCF21 24883060 1074221 Positive_regulation TNF TCF21 25053922 1627962 Positive_regulation TNF TCF21 25175787 396735 Positive_regulation TNF TCF21 25210730 3006559 Positive_regulation TNF TCF21 25215307 1623217 Positive_regulation TNF TCF21 8381117 1447720 Positive_regulation TNF TCF21 8391000 1448064 Positive_regulation TNF TCF21 9400717 797380 Positive_regulation TNF TCF23 11516343 994125 Positive_regulation TNF TCF23 16192667 1740073 Positive_regulation TNF TCF23 19351711 708244 Positive_regulation TNF TCF23 20680494 1654484 Positive_regulation TNF TCF23 21966220 3209142 Positive_regulation TNF TCF23 22054645 1898701 Positive_regulation TNF TCF23 22225778 469609 Positive_regulation TNF TCF23 22479453 2615372 Positive_regulation TNF TCF23 22645700 1082579 Positive_regulation TNF TCF23 22685371 1749996 Positive_regulation TNF TCF23 23125487 1750655 Positive_regulation TNF TCF23 23481064 1045270 Positive_regulation TNF TCF23 23509807 180578 Positive_regulation TNF TCF23 23843781 696924 Positive_regulation TNF TCF23 23864765 1754255 Positive_regulation TNF TCF23 24116272 204220 Positive_regulation TNF TCF23 24591741 1046892 Positive_regulation TNF TCF23 24883060 1074225 Positive_regulation TNF TCF23 25053922 1627966 Positive_regulation TNF TCF23 25175787 396739 Positive_regulation TNF TCF23 25210730 3006563 Positive_regulation TNF TCF23 25215307 1623221 Positive_regulation TNF TCF23 8381117 1447724 Positive_regulation TNF TCF23 8391000 1448068 Positive_regulation TNF TCF23 9400717 797384 Positive_regulation TNF TCF24 11516343 994127 Positive_regulation TNF TCF24 16192667 1740075 Positive_regulation TNF TCF24 19351711 708246 Positive_regulation TNF TCF24 20680494 1654486 Positive_regulation TNF TCF24 21966220 3209144 Positive_regulation TNF TCF24 22054645 1898703 Positive_regulation TNF TCF24 22225778 469611 Positive_regulation TNF TCF24 22479453 2615374 Positive_regulation TNF TCF24 22645700 1082581 Positive_regulation TNF TCF24 22685371 1749998 Positive_regulation TNF TCF24 23125487 1750657 Positive_regulation TNF TCF24 23481064 1045272 Positive_regulation TNF TCF24 23509807 180580 Positive_regulation TNF TCF24 23843781 696926 Positive_regulation TNF TCF24 23864765 1754257 Positive_regulation TNF TCF24 24116272 204222 Positive_regulation TNF TCF24 24591741 1046894 Positive_regulation TNF TCF24 24883060 1074227 Positive_regulation TNF TCF24 25053922 1627968 Positive_regulation TNF TCF24 25175787 396741 Positive_regulation TNF TCF24 25210730 3006565 Positive_regulation TNF TCF24 25215307 1623223 Positive_regulation TNF TCF24 8381117 1447726 Positive_regulation TNF TCF24 8391000 1448070 Positive_regulation TNF TCF24 9400717 797386 Positive_regulation TNF TCF25 11516343 994126 Positive_regulation TNF TCF25 16192667 1740074 Positive_regulation TNF TCF25 19351711 708245 Positive_regulation TNF TCF25 20680494 1654485 Positive_regulation TNF TCF25 21966220 3209143 Positive_regulation TNF TCF25 22054645 1898702 Positive_regulation TNF TCF25 22225778 469610 Positive_regulation TNF TCF25 22479453 2615373 Positive_regulation TNF TCF25 22645700 1082580 Positive_regulation TNF TCF25 22685371 1749997 Positive_regulation TNF TCF25 23125487 1750656 Positive_regulation TNF TCF25 23481064 1045271 Positive_regulation TNF TCF25 23509807 180579 Positive_regulation TNF TCF25 23843781 696925 Positive_regulation TNF TCF25 23864765 1754256 Positive_regulation TNF TCF25 24116272 204221 Positive_regulation TNF TCF25 24591741 1046893 Positive_regulation TNF TCF25 24883060 1074226 Positive_regulation TNF TCF25 25053922 1627967 Positive_regulation TNF TCF25 25175787 396740 Positive_regulation TNF TCF25 25210730 3006564 Positive_regulation TNF TCF25 25215307 1623222 Positive_regulation TNF TCF25 8381117 1447725 Positive_regulation TNF TCF25 8391000 1448069 Positive_regulation TNF TCF25 9400717 797385 Positive_regulation TNF TCF3 11516343 994122 Positive_regulation TNF TCF3 16192667 1740070 Positive_regulation TNF TCF3 19351711 708241 Positive_regulation TNF TCF3 20680494 1654481 Positive_regulation TNF TCF3 21966220 3209139 Positive_regulation TNF TCF3 22054645 1898698 Positive_regulation TNF TCF3 22225778 469606 Positive_regulation TNF TCF3 22479453 2615369 Positive_regulation TNF TCF3 22645700 1082576 Positive_regulation TNF TCF3 22685371 1749993 Positive_regulation TNF TCF3 23125487 1750652 Positive_regulation TNF TCF3 23481064 1045267 Positive_regulation TNF TCF3 23509807 180575 Positive_regulation TNF TCF3 23843781 696921 Positive_regulation TNF TCF3 23864765 1754252 Positive_regulation TNF TCF3 24116272 204217 Positive_regulation TNF TCF3 24591741 1046889 Positive_regulation TNF TCF3 24883060 1074222 Positive_regulation TNF TCF3 25053922 1627963 Positive_regulation TNF TCF3 25175787 396736 Positive_regulation TNF TCF3 25210730 3006560 Positive_regulation TNF TCF3 25215307 1623218 Positive_regulation TNF TCF3 8381117 1447721 Positive_regulation TNF TCF3 8391000 1448065 Positive_regulation TNF TCF3 9400717 797381 Positive_regulation TNF TCF4 11516343 994123 Positive_regulation TNF TCF4 16192667 1740071 Positive_regulation TNF TCF4 19351711 708242 Positive_regulation TNF TCF4 20680494 1654482 Positive_regulation TNF TCF4 21966220 3209140 Positive_regulation TNF TCF4 22054645 1898699 Positive_regulation TNF TCF4 22225778 469607 Positive_regulation TNF TCF4 22479453 2615370 Positive_regulation TNF TCF4 22645700 1082577 Positive_regulation TNF TCF4 22685371 1749994 Positive_regulation TNF TCF4 23125487 1750653 Positive_regulation TNF TCF4 23481064 1045268 Positive_regulation TNF TCF4 23509807 180576 Positive_regulation TNF TCF4 23843781 696922 Positive_regulation TNF TCF4 23864765 1754253 Positive_regulation TNF TCF4 24116272 204218 Positive_regulation TNF TCF4 24591741 1046890 Positive_regulation TNF TCF4 24883060 1074223 Positive_regulation TNF TCF4 25053922 1627964 Positive_regulation TNF TCF4 25175787 396737 Positive_regulation TNF TCF4 25210730 3006561 Positive_regulation TNF TCF4 25215307 1623219 Positive_regulation TNF TCF4 8381117 1447722 Positive_regulation TNF TCF4 8391000 1448066 Positive_regulation TNF TCF4 9400717 797382 Positive_regulation TNF TCF7 11516343 994124 Positive_regulation TNF TCF7 16192667 1740072 Positive_regulation TNF TCF7 19351711 708243 Positive_regulation TNF TCF7 20680494 1654483 Positive_regulation TNF TCF7 21966220 3209141 Positive_regulation TNF TCF7 22054645 1898700 Positive_regulation TNF TCF7 22225778 469608 Positive_regulation TNF TCF7 22479453 2615371 Positive_regulation TNF TCF7 22645700 1082578 Positive_regulation TNF TCF7 22685371 1749995 Positive_regulation TNF TCF7 23125487 1750654 Positive_regulation TNF TCF7 23481064 1045269 Positive_regulation TNF TCF7 23509807 180577 Positive_regulation TNF TCF7 23843781 696923 Positive_regulation TNF TCF7 23864765 1754254 Positive_regulation TNF TCF7 24116272 204219 Positive_regulation TNF TCF7 24591741 1046891 Positive_regulation TNF TCF7 24883060 1074224 Positive_regulation TNF TCF7 25053922 1627965 Positive_regulation TNF TCF7 25175787 396738 Positive_regulation TNF TCF7 25210730 3006562 Positive_regulation TNF TCF7 25215307 1623220 Positive_regulation TNF TCF7 8381117 1447723 Positive_regulation TNF TCF7 8391000 1448067 Positive_regulation TNF TCF7 9400717 797383 Positive_regulation TNF TFAM 22469910 1086623 Positive_regulation TNF TFAM 22469910 1086624 Positive_regulation TNF TFAM 22469910 1086626 Positive_regulation TNF TFAM 22469910 1086628 Positive_regulation TNF TFAM 22469910 1086634 Positive_regulation TNF TFAP2A 23785430 2805875 Positive_regulation TNF TGFA 2295877 1569298 Positive_regulation TNF TGFB1 17485515 1545961 Positive_regulation TNF TGM4 22291795 95046 Positive_regulation TNF THEMIS2 20644716 2455930 Positive_regulation TNF THRA 19712471 1625646 Positive_regulation TNF THRAP3 19712471 1625654 Positive_regulation TNF THY1 20657842 2456463 Positive_regulation TNF THY1 20657842 2456465 Positive_regulation TNF THY1 25345415 3146302 Positive_regulation TNF TIMP1 23755201 2801916 Positive_regulation TNF TIMP1 8976186 1599722 Positive_regulation TNF TJP1 21853060 2542970 Positive_regulation TNF TJP1 25200553 1234625 Positive_regulation TNF TLR1 12486107 1525646 Positive_regulation TNF TLR1 12719479 1526941 Positive_regulation TNF TLR1 16542467 105074 Positive_regulation TNF TLR1 17485511 1545599 Positive_regulation TNF TLR1 17850179 2263306 Positive_regulation TNF TLR1 17895997 2378749 Positive_regulation TNF TLR1 18195076 1548694 Positive_regulation TNF TLR1 18227218 1548825 Positive_regulation TNF TLR1 18411340 1550332 Positive_regulation TNF TLR1 18446192 2387896 Positive_regulation TNF TLR1 18493310 2389282 Positive_regulation TNF TLR1 18644971 1551610 Positive_regulation TNF TLR1 18779348 1551901 Positive_regulation TNF TLR1 19077314 1727819 Positive_regulation TNF TLR1 19183807 2405085 Positive_regulation TNF TLR1 19363483 1952368 Positive_regulation TNF TLR1 19386086 242370 Positive_regulation TNF TLR1 19386086 242390 Positive_regulation TNF TLR1 19386086 242418 Positive_regulation TNF TLR1 19419540 3117778 Positive_regulation TNF TLR1 19667063 1555769 Positive_regulation TNF TLR1 19668221 1952721 Positive_regulation TNF TLR1 20204070 1213901 Positive_regulation TNF TLR1 20584912 1377094 Positive_regulation TNF TLR1 20617179 3047828 Positive_regulation TNF TLR1 20644716 2455919 Positive_regulation TNF TLR1 20703784 1491323 Positive_regulation TNF TLR1 20706689 1747828 Positive_regulation TNF TLR1 20837769 1379086 Positive_regulation TNF TLR1 21098092 1561801 Positive_regulation TNF TLR1 21188217 1081605 Positive_regulation TNF TLR1 21762537 3214225 Positive_regulation TNF TLR1 21789039 979891 Positive_regulation TNF TLR1 21829730 2542549 Positive_regulation TNF TLR1 21829730 2542569 Positive_regulation TNF TLR1 21852947 3052887 Positive_regulation TNF TLR1 21861860 123672 Positive_regulation TNF TLR1 21915309 2553171 Positive_regulation TNF TLR1 21915309 2553172 Positive_regulation TNF TLR1 22110383 1058497 Positive_regulation TNF TLR1 22277195 1660772 Positive_regulation TNF TLR1 22461749 3229285 Positive_regulation TNF TLR1 22484733 1957108 Positive_regulation TNF TLR1 22484733 1957179 Positive_regulation TNF TLR1 22513098 125410 Positive_regulation TNF TLR1 22523644 1680571 Positive_regulation TNF TLR1 22556042 1050644 Positive_regulation TNF TLR1 22556042 1050670 Positive_regulation TNF TLR1 22556042 1050702 Positive_regulation TNF TLR1 22754655 3221178 Positive_regulation TNF TLR1 22808181 2665035 Positive_regulation TNF TLR1 22829768 3058173 Positive_regulation TNF TLR1 22876243 902864 Positive_regulation TNF TLR1 22883744 1664706 Positive_regulation TNF TLR1 22916300 2680741 Positive_regulation TNF TLR1 23071254 1569599 Positive_regulation TNF TLR1 23239947 3229344 Positive_regulation TNF TLR1 23557436 359054 Positive_regulation TNF TLR1 23638088 2787586 Positive_regulation TNF TLR1 23741282 3190583 Positive_regulation TNF TLR1 23787171 1666827 Positive_regulation TNF TLR1 23800014 1232197 Positive_regulation TNF TLR1 23898332 908462 Positive_regulation TNF TLR1 23935250 1754398 Positive_regulation TNF TLR1 23935651 638083 Positive_regulation TNF TLR1 23935651 638114 Positive_regulation TNF TLR1 23951210 2833735 Positive_regulation TNF TLR1 23959031 3217807 Positive_regulation TNF TLR1 24058791 1705776 Positive_regulation TNF TLR1 24069456 2853353 Positive_regulation TNF TLR1 24205068 2875174 Positive_regulation TNF TLR1 24205328 2875963 Positive_regulation TNF TLR1 24205328 2876026 Positive_regulation TNF TLR1 24237425 6670 Positive_regulation TNF TLR1 24282429 639145 Positive_regulation TNF TLR1 24409430 1498611 Positive_regulation TNF TLR1 24479879 538919 Positive_regulation TNF TLR1 24586553 2925432 Positive_regulation TNF TLR1 24609617 1050556 Positive_regulation TNF TLR1 24734221 865063 Positive_regulation TNF TLR1 24758719 1483087 Positive_regulation TNF TLR1 24824830 2969462 Positive_regulation TNF TLR1 25071732 927007 Positive_regulation TNF TLR1 25078879 660727 Positive_regulation TNF TLR1 25101057 881024 Positive_regulation TNF TLR1 25133189 196820 Positive_regulation TNF TLR1 25161655 913876 Positive_regulation TNF TLR1 25165887 3069083 Positive_regulation TNF TLR1 25222785 1045978 Positive_regulation TNF TLR1 25295753 3012721 Positive_regulation TNF TLR1 25295753 3012762 Positive_regulation TNF TLR1 25329467 3016104 Positive_regulation TNF TLR1 25530682 1763443 Positive_regulation TNF TLR1 25541965 3035927 Positive_regulation TNF TLR1 25550115 1734364 Positive_regulation TNF TLR1 25550115 1734388 Positive_regulation TNF TLR1 25615645 3038603 Positive_regulation TNF TLR1 PMC3242235 1702526 Positive_regulation TNF TLR10 12486107 1525654 Positive_regulation TNF TLR10 12719479 1526949 Positive_regulation TNF TLR10 16542467 105082 Positive_regulation TNF TLR10 17485511 1545607 Positive_regulation TNF TLR10 17850179 2263314 Positive_regulation TNF TLR10 17895997 2378757 Positive_regulation TNF TLR10 18195076 1548702 Positive_regulation TNF TLR10 18227218 1548833 Positive_regulation TNF TLR10 18411340 1550340 Positive_regulation TNF TLR10 18446192 2387904 Positive_regulation TNF TLR10 18493310 2389290 Positive_regulation TNF TLR10 18644971 1551618 Positive_regulation TNF TLR10 18779348 1551909 Positive_regulation TNF TLR10 19077314 1727827 Positive_regulation TNF TLR10 19183807 2405093 Positive_regulation TNF TLR10 19363483 1952376 Positive_regulation TNF TLR10 19386086 242378 Positive_regulation TNF TLR10 19386086 242398 Positive_regulation TNF TLR10 19386086 242426 Positive_regulation TNF TLR10 19419540 3117786 Positive_regulation TNF TLR10 19667063 1555777 Positive_regulation TNF TLR10 19668221 1952729 Positive_regulation TNF TLR10 20204070 1213909 Positive_regulation TNF TLR10 20584912 1377102 Positive_regulation TNF TLR10 20617179 3047836 Positive_regulation TNF TLR10 20644716 2455928 Positive_regulation TNF TLR10 20703784 1491331 Positive_regulation TNF TLR10 20706689 1747836 Positive_regulation TNF TLR10 20837769 1379094 Positive_regulation TNF TLR10 21098092 1561809 Positive_regulation TNF TLR10 21188217 1081613 Positive_regulation TNF TLR10 21762537 3214233 Positive_regulation TNF TLR10 21789039 979899 Positive_regulation TNF TLR10 21829730 2542557 Positive_regulation TNF TLR10 21829730 2542577 Positive_regulation TNF TLR10 21852947 3052895 Positive_regulation TNF TLR10 21861860 123680 Positive_regulation TNF TLR10 21915309 2553187 Positive_regulation TNF TLR10 21915309 2553188 Positive_regulation TNF TLR10 22110383 1058505 Positive_regulation TNF TLR10 22277195 1660780 Positive_regulation TNF TLR10 22461749 3229293 Positive_regulation TNF TLR10 22484733 1957116 Positive_regulation TNF TLR10 22484733 1957187 Positive_regulation TNF TLR10 22513098 125418 Positive_regulation TNF TLR10 22523644 1680580 Positive_regulation TNF TLR10 22556042 1050652 Positive_regulation TNF TLR10 22556042 1050678 Positive_regulation TNF TLR10 22556042 1050710 Positive_regulation TNF TLR10 22754655 3221186 Positive_regulation TNF TLR10 22808181 2665043 Positive_regulation TNF TLR10 22829768 3058182 Positive_regulation TNF TLR10 22876243 902872 Positive_regulation TNF TLR10 22883744 1664714 Positive_regulation TNF TLR10 22916300 2680749 Positive_regulation TNF TLR10 23071254 1569607 Positive_regulation TNF TLR10 23239947 3229352 Positive_regulation TNF TLR10 23557436 359062 Positive_regulation TNF TLR10 23638088 2787594 Positive_regulation TNF TLR10 23787171 1666835 Positive_regulation TNF TLR10 23800014 1232205 Positive_regulation TNF TLR10 23898332 908470 Positive_regulation TNF TLR10 23935250 1754406 Positive_regulation TNF TLR10 23935651 638091 Positive_regulation TNF TLR10 23935651 638123 Positive_regulation TNF TLR10 23951210 2833743 Positive_regulation TNF TLR10 23959031 3217815 Positive_regulation TNF TLR10 24058791 1705784 Positive_regulation TNF TLR10 24069456 2853361 Positive_regulation TNF TLR10 24205068 2875182 Positive_regulation TNF TLR10 24205328 2875971 Positive_regulation TNF TLR10 24205328 2876034 Positive_regulation TNF TLR10 24282429 639153 Positive_regulation TNF TLR10 24409430 1498619 Positive_regulation TNF TLR10 24479879 538927 Positive_regulation TNF TLR10 24586553 2925440 Positive_regulation TNF TLR10 24609617 1050564 Positive_regulation TNF TLR10 24734221 865071 Positive_regulation TNF TLR10 24758719 1483096 Positive_regulation TNF TLR10 24824830 2969470 Positive_regulation TNF TLR10 25071732 927015 Positive_regulation TNF TLR10 25078879 660735 Positive_regulation TNF TLR10 25101057 881032 Positive_regulation TNF TLR10 25133189 196828 Positive_regulation TNF TLR10 25161655 913884 Positive_regulation TNF TLR10 25165887 3069091 Positive_regulation TNF TLR10 25222785 1045986 Positive_regulation TNF TLR10 25295753 3012729 Positive_regulation TNF TLR10 25295753 3012770 Positive_regulation TNF TLR10 25329467 3016112 Positive_regulation TNF TLR10 25530682 1763451 Positive_regulation TNF TLR10 25541965 3035935 Positive_regulation TNF TLR10 25550115 1734372 Positive_regulation TNF TLR10 25550115 1734396 Positive_regulation TNF TLR10 25615645 3038611 Positive_regulation TNF TLR10 PMC3242235 1702534 Positive_regulation TNF TLR2 12486107 1525647 Positive_regulation TNF TLR2 12719479 1526942 Positive_regulation TNF TLR2 16304610 3039062 Positive_regulation TNF TLR2 16344862 3039084 Positive_regulation TNF TLR2 16542467 105075 Positive_regulation TNF TLR2 17485511 1545597 Positive_regulation TNF TLR2 17485511 1545600 Positive_regulation TNF TLR2 17485511 1545718 Positive_regulation TNF TLR2 17485511 1545737 Positive_regulation TNF TLR2 17850179 2263307 Positive_regulation TNF TLR2 17895997 2378750 Positive_regulation TNF TLR2 17998391 1547796 Positive_regulation TNF TLR2 18001488 109394 Positive_regulation TNF TLR2 18195076 1548695 Positive_regulation TNF TLR2 18227218 1548826 Positive_regulation TNF TLR2 18411340 1550333 Positive_regulation TNF TLR2 18446192 2387897 Positive_regulation TNF TLR2 18493310 2389283 Positive_regulation TNF TLR2 18644971 1551611 Positive_regulation TNF TLR2 18779348 1551902 Positive_regulation TNF TLR2 19077314 1727820 Positive_regulation TNF TLR2 19183807 2405086 Positive_regulation TNF TLR2 19363483 1952369 Positive_regulation TNF TLR2 19386086 242371 Positive_regulation TNF TLR2 19386086 242391 Positive_regulation TNF TLR2 19386086 242419 Positive_regulation TNF TLR2 19419540 3117779 Positive_regulation TNF TLR2 19519926 113554 Positive_regulation TNF TLR2 19667063 1555770 Positive_regulation TNF TLR2 19668221 1952722 Positive_regulation TNF TLR2 19806220 2427820 Positive_regulation TNF TLR2 19847289 2429167 Positive_regulation TNF TLR2 19849823 117509 Positive_regulation TNF TLR2 19849823 117526 Positive_regulation TNF TLR2 19936071 2370601 Positive_regulation TNF TLR2 19966777 1960919 Positive_regulation TNF TLR2 20098705 2437914 Positive_regulation TNF TLR2 20204070 1213902 Positive_regulation TNF TLR2 20584912 1377095 Positive_regulation TNF TLR2 20617179 3047829 Positive_regulation TNF TLR2 20644716 2455920 Positive_regulation TNF TLR2 20703784 1491324 Positive_regulation TNF TLR2 20706658 1747817 Positive_regulation TNF TLR2 20706689 1747829 Positive_regulation TNF TLR2 20837769 1379087 Positive_regulation TNF TLR2 20946675 1723264 Positive_regulation TNF TLR2 21049294 665225 Positive_regulation TNF TLR2 21098092 1561802 Positive_regulation TNF TLR2 21188217 1081606 Positive_regulation TNF TLR2 21483834 2512376 Positive_regulation TNF TLR2 21556316 1078205 Positive_regulation TNF TLR2 21611196 2523848 Positive_regulation TNF TLR2 21762537 3214226 Positive_regulation TNF TLR2 21789039 979892 Positive_regulation TNF TLR2 21829730 2542550 Positive_regulation TNF TLR2 21829730 2542570 Positive_regulation TNF TLR2 21852947 3052888 Positive_regulation TNF TLR2 21861860 123673 Positive_regulation TNF TLR2 21876792 798892 Positive_regulation TNF TLR2 21911421 1565249 Positive_regulation TNF TLR2 21915309 2553173 Positive_regulation TNF TLR2 21915309 2553174 Positive_regulation TNF TLR2 22110383 1058498 Positive_regulation TNF TLR2 22116297 1050363 Positive_regulation TNF TLR2 22123833 1394065 Positive_regulation TNF TLR2 22132309 1680461 Positive_regulation TNF TLR2 22194732 923855 Positive_regulation TNF TLR2 22194732 923856 Positive_regulation TNF TLR2 22194732 923881 Positive_regulation TNF TLR2 22277195 1660773 Positive_regulation TNF TLR2 22384111 2604293 Positive_regulation TNF TLR2 22417709 125206 Positive_regulation TNF TLR2 22434667 1050240 Positive_regulation TNF TLR2 22434667 1050244 Positive_regulation TNF TLR2 22461749 3229286 Positive_regulation TNF TLR2 22470546 2614556 Positive_regulation TNF TLR2 22484733 1957109 Positive_regulation TNF TLR2 22484733 1957180 Positive_regulation TNF TLR2 22513098 125411 Positive_regulation TNF TLR2 22523644 1680572 Positive_regulation TNF TLR2 22556042 1050645 Positive_regulation TNF TLR2 22556042 1050671 Positive_regulation TNF TLR2 22556042 1050697 Positive_regulation TNF TLR2 22556042 1050703 Positive_regulation TNF TLR2 22566801 898563 Positive_regulation TNF TLR2 22566960 900522 Positive_regulation TNF TLR2 22566960 900554 Positive_regulation TNF TLR2 22566960 900560 Positive_regulation TNF TLR2 22570745 1024136 Positive_regulation TNF TLR2 22754655 3221179 Positive_regulation TNF TLR2 22808181 2665016 Positive_regulation TNF TLR2 22808181 2665036 Positive_regulation TNF TLR2 22829768 3058174 Positive_regulation TNF TLR2 22866178 2671958 Positive_regulation TNF TLR2 22876243 902865 Positive_regulation TNF TLR2 22883744 1664707 Positive_regulation TNF TLR2 22916300 2680742 Positive_regulation TNF TLR2 23071254 1569600 Positive_regulation TNF TLR2 23097717 1152855 Positive_regulation TNF TLR2 23239947 3229345 Positive_regulation TNF TLR2 23514422 1683642 Positive_regulation TNF TLR2 23557436 359055 Positive_regulation TNF TLR2 23638088 2787587 Positive_regulation TNF TLR2 23741282 3190584 Positive_regulation TNF TLR2 23762847 182044 Positive_regulation TNF TLR2 23787171 1666828 Positive_regulation TNF TLR2 23800014 1232198 Positive_regulation TNF TLR2 23826189 2810742 Positive_regulation TNF TLR2 23840549 2815175 Positive_regulation TNF TLR2 23894549 2825261 Positive_regulation TNF TLR2 23898332 908463 Positive_regulation TNF TLR2 23935250 1754399 Positive_regulation TNF TLR2 23935651 638084 Positive_regulation TNF TLR2 23935651 638115 Positive_regulation TNF TLR2 23935651 638116 Positive_regulation TNF TLR2 23951210 2833736 Positive_regulation TNF TLR2 23959031 3217808 Positive_regulation TNF TLR2 23965413 1618302 Positive_regulation TNF TLR2 24013774 2842161 Positive_regulation TNF TLR2 24058791 1705777 Positive_regulation TNF TLR2 24069456 2853354 Positive_regulation TNF TLR2 24098413 2856280 Positive_regulation TNF TLR2 24205068 2875175 Positive_regulation TNF TLR2 24205328 2875964 Positive_regulation TNF TLR2 24205328 2876027 Positive_regulation TNF TLR2 24278450 2885955 Positive_regulation TNF TLR2 24282429 639146 Positive_regulation TNF TLR2 24341851 346162 Positive_regulation TNF TLR2 24349012 2896592 Positive_regulation TNF TLR2 24349012 2896619 Positive_regulation TNF TLR2 24409430 1498612 Positive_regulation TNF TLR2 24479879 538920 Positive_regulation TNF TLR2 24489660 2915579 Positive_regulation TNF TLR2 24586553 2925433 Positive_regulation TNF TLR2 24609617 1050557 Positive_regulation TNF TLR2 24669209 685255 Positive_regulation TNF TLR2 24722226 3066658 Positive_regulation TNF TLR2 24734221 865064 Positive_regulation TNF TLR2 24743542 2955617 Positive_regulation TNF TLR2 24757287 1758244 Positive_regulation TNF TLR2 24758719 1483088 Positive_regulation TNF TLR2 24758719 1483089 Positive_regulation TNF TLR2 24824830 2969463 Positive_regulation TNF TLR2 24983999 2986008 Positive_regulation TNF TLR2 24995007 913213 Positive_regulation TNF TLR2 25053922 1627926 Positive_regulation TNF TLR2 25057505 1622618 Positive_regulation TNF TLR2 25071732 927008 Positive_regulation TNF TLR2 25071732 927059 Positive_regulation TNF TLR2 25078879 660728 Positive_regulation TNF TLR2 25093709 34270 Positive_regulation TNF TLR2 25101057 881025 Positive_regulation TNF TLR2 25133189 196821 Positive_regulation TNF TLR2 25147831 1623107 Positive_regulation TNF TLR2 25161655 913877 Positive_regulation TNF TLR2 25165887 3069084 Positive_regulation TNF TLR2 25222785 1045979 Positive_regulation TNF TLR2 25250027 914200 Positive_regulation TNF TLR2 25250027 914209 Positive_regulation TNF TLR2 25295753 3012722 Positive_regulation TNF TLR2 25295753 3012763 Positive_regulation TNF TLR2 25329057 3015866 Positive_regulation TNF TLR2 25329467 3016105 Positive_regulation TNF TLR2 25400920 1037332 Positive_regulation TNF TLR2 25525300 1763262 Positive_regulation TNF TLR2 25530682 1763444 Positive_regulation TNF TLR2 25531754 3035279 Positive_regulation TNF TLR2 25531754 3035282 Positive_regulation TNF TLR2 25541965 3035928 Positive_regulation TNF TLR2 25550115 1734365 Positive_regulation TNF TLR2 25550115 1734389 Positive_regulation TNF TLR2 25595212 3211308 Positive_regulation TNF TLR2 25615645 3038604 Positive_regulation TNF TLR2 PMC3242235 1702527 Positive_regulation TNF TLR3 12486107 1525648 Positive_regulation TNF TLR3 12719479 1526943 Positive_regulation TNF TLR3 15197227 1532943 Positive_regulation TNF TLR3 16542467 105076 Positive_regulation TNF TLR3 17485511 1545601 Positive_regulation TNF TLR3 17850179 2263308 Positive_regulation TNF TLR3 17895997 2378751 Positive_regulation TNF TLR3 18195076 1548696 Positive_regulation TNF TLR3 18227218 1548827 Positive_regulation TNF TLR3 18411340 1550334 Positive_regulation TNF TLR3 18446192 2387898 Positive_regulation TNF TLR3 18493310 2389284 Positive_regulation TNF TLR3 18644971 1551612 Positive_regulation TNF TLR3 18779348 1551903 Positive_regulation TNF TLR3 19077314 1727821 Positive_regulation TNF TLR3 19088911 2214856 Positive_regulation TNF TLR3 19122812 2404045 Positive_regulation TNF TLR3 19122812 2404046 Positive_regulation TNF TLR3 19183807 2405087 Positive_regulation TNF TLR3 19363483 1952370 Positive_regulation TNF TLR3 19386086 242372 Positive_regulation TNF TLR3 19386086 242392 Positive_regulation TNF TLR3 19386086 242420 Positive_regulation TNF TLR3 19419540 3117780 Positive_regulation TNF TLR3 19667063 1555771 Positive_regulation TNF TLR3 19668221 1952723 Positive_regulation TNF TLR3 20204070 1213903 Positive_regulation TNF TLR3 20584912 1377096 Positive_regulation TNF TLR3 20617179 3047830 Positive_regulation TNF TLR3 20644716 2455921 Positive_regulation TNF TLR3 20703784 1491325 Positive_regulation TNF TLR3 20706689 1747830 Positive_regulation TNF TLR3 20837769 1379088 Positive_regulation TNF TLR3 21098092 1561803 Positive_regulation TNF TLR3 21188217 1081607 Positive_regulation TNF TLR3 21342497 1897897 Positive_regulation TNF TLR3 21342497 1897910 Positive_regulation TNF TLR3 21556316 1078206 Positive_regulation TNF TLR3 21762537 3214227 Positive_regulation TNF TLR3 21789039 979893 Positive_regulation TNF TLR3 21829730 2542551 Positive_regulation TNF TLR3 21829730 2542571 Positive_regulation TNF TLR3 21852947 3052889 Positive_regulation TNF TLR3 21860608 1038267 Positive_regulation TNF TLR3 21861860 123674 Positive_regulation TNF TLR3 21915309 2553175 Positive_regulation TNF TLR3 21915309 2553176 Positive_regulation TNF TLR3 21994612 3219018 Positive_regulation TNF TLR3 22110383 1058499 Positive_regulation TNF TLR3 22276993 357102 Positive_regulation TNF TLR3 22277195 1660774 Positive_regulation TNF TLR3 22461749 3229287 Positive_regulation TNF TLR3 22484733 1957110 Positive_regulation TNF TLR3 22484733 1957181 Positive_regulation TNF TLR3 22513098 125412 Positive_regulation TNF TLR3 22523644 1680573 Positive_regulation TNF TLR3 22523644 1680574 Positive_regulation TNF TLR3 22523644 1680634 Positive_regulation TNF TLR3 22556042 1050646 Positive_regulation TNF TLR3 22556042 1050672 Positive_regulation TNF TLR3 22556042 1050704 Positive_regulation TNF TLR3 22661952 957400 Positive_regulation TNF TLR3 22754655 3221180 Positive_regulation TNF TLR3 22808176 2664959 Positive_regulation TNF TLR3 22808181 2665037 Positive_regulation TNF TLR3 22829768 3058175 Positive_regulation TNF TLR3 22876243 902866 Positive_regulation TNF TLR3 22883744 1664708 Positive_regulation TNF TLR3 22916300 2680743 Positive_regulation TNF TLR3 23071254 1569601 Positive_regulation TNF TLR3 23239947 3229346 Positive_regulation TNF TLR3 23247502 3221980 Positive_regulation TNF TLR3 23557436 359056 Positive_regulation TNF TLR3 23638088 2787588 Positive_regulation TNF TLR3 23787171 1666829 Positive_regulation TNF TLR3 23787171 1666857 Positive_regulation TNF TLR3 23800014 1232199 Positive_regulation TNF TLR3 23898332 908464 Positive_regulation TNF TLR3 23935250 1754400 Positive_regulation TNF TLR3 23935651 638085 Positive_regulation TNF TLR3 23935651 638117 Positive_regulation TNF TLR3 23951210 2833737 Positive_regulation TNF TLR3 23959031 3217809 Positive_regulation TNF TLR3 24058791 1705778 Positive_regulation TNF TLR3 24069456 2853355 Positive_regulation TNF TLR3 24165198 270214 Positive_regulation TNF TLR3 24205068 2875176 Positive_regulation TNF TLR3 24205328 2875965 Positive_regulation TNF TLR3 24205328 2876028 Positive_regulation TNF TLR3 24282429 639147 Positive_regulation TNF TLR3 24367254 3065315 Positive_regulation TNF TLR3 24409430 1498613 Positive_regulation TNF TLR3 24454470 639493 Positive_regulation TNF TLR3 24479879 538921 Positive_regulation TNF TLR3 24586553 2925434 Positive_regulation TNF TLR3 24586659 2926022 Positive_regulation TNF TLR3 24609617 1050558 Positive_regulation TNF TLR3 24734221 865065 Positive_regulation TNF TLR3 24743542 2955618 Positive_regulation TNF TLR3 24758719 1483090 Positive_regulation TNF TLR3 24762979 2372603 Positive_regulation TNF TLR3 24824830 2969464 Positive_regulation TNF TLR3 25062998 1620053 Positive_regulation TNF TLR3 25071732 927009 Positive_regulation TNF TLR3 25071732 927060 Positive_regulation TNF TLR3 25078879 660729 Positive_regulation TNF TLR3 25101057 881026 Positive_regulation TNF TLR3 25133189 196822 Positive_regulation TNF TLR3 25161655 913878 Positive_regulation TNF TLR3 25165887 3069085 Positive_regulation TNF TLR3 25206644 2005479 Positive_regulation TNF TLR3 25222785 1045980 Positive_regulation TNF TLR3 25295753 3012723 Positive_regulation TNF TLR3 25295753 3012764 Positive_regulation TNF TLR3 25329467 3016106 Positive_regulation TNF TLR3 25393122 3025505 Positive_regulation TNF TLR3 25530682 1763445 Positive_regulation TNF TLR3 25541965 3035929 Positive_regulation TNF TLR3 25550115 1734366 Positive_regulation TNF TLR3 25550115 1734390 Positive_regulation TNF TLR3 25595212 3211309 Positive_regulation TNF TLR3 25615645 3038605 Positive_regulation TNF TLR3 PMC3242235 1702528 Positive_regulation TNF TLR4 11781369 1522133 Positive_regulation TNF TLR4 12486107 1525649 Positive_regulation TNF TLR4 12566416 1525857 Positive_regulation TNF TLR4 12719479 1526944 Positive_regulation TNF TLR4 15197227 1532944 Positive_regulation TNF TLR4 16322770 3039074 Positive_regulation TNF TLR4 16542467 105077 Positive_regulation TNF TLR4 16717116 1540382 Positive_regulation TNF TLR4 17242961 810096 Positive_regulation TNF TLR4 17485511 1545602 Positive_regulation TNF TLR4 17592640 392069 Positive_regulation TNF TLR4 17850179 2263309 Positive_regulation TNF TLR4 17895997 2378752 Positive_regulation TNF TLR4 18195076 1548697 Positive_regulation TNF TLR4 18227218 1548828 Positive_regulation TNF TLR4 18411340 1550335 Positive_regulation TNF TLR4 18446192 2387899 Positive_regulation TNF TLR4 18493310 2389285 Positive_regulation TNF TLR4 18498620 352180 Positive_regulation TNF TLR4 18510752 1655529 Positive_regulation TNF TLR4 18617992 3041610 Positive_regulation TNF TLR4 18644971 1551613 Positive_regulation TNF TLR4 18779348 1551904 Positive_regulation TNF TLR4 18987746 2400163 Positive_regulation TNF TLR4 18987746 2400168 Positive_regulation TNF TLR4 19077314 1727822 Positive_regulation TNF TLR4 19183807 2405088 Positive_regulation TNF TLR4 19363483 1952371 Positive_regulation TNF TLR4 19386086 242373 Positive_regulation TNF TLR4 19386086 242393 Positive_regulation TNF TLR4 19386086 242410 Positive_regulation TNF TLR4 19386086 242421 Positive_regulation TNF TLR4 19419540 3117781 Positive_regulation TNF TLR4 19667063 1555772 Positive_regulation TNF TLR4 19668221 1952724 Positive_regulation TNF TLR4 19675137 710815 Positive_regulation TNF TLR4 19806220 2427821 Positive_regulation TNF TLR4 20098705 2437915 Positive_regulation TNF TLR4 20204070 1213904 Positive_regulation TNF TLR4 20360853 2444893 Positive_regulation TNF TLR4 20584912 1377097 Positive_regulation TNF TLR4 20617179 3047831 Positive_regulation TNF TLR4 20644716 2455922 Positive_regulation TNF TLR4 20644716 2455923 Positive_regulation TNF TLR4 20703784 1491326 Positive_regulation TNF TLR4 20706689 1747831 Positive_regulation TNF TLR4 20827314 979296 Positive_regulation TNF TLR4 20827416 1049599 Positive_regulation TNF TLR4 20837769 1379089 Positive_regulation TNF TLR4 20876708 729658 Positive_regulation TNF TLR4 20946675 1723347 Positive_regulation TNF TLR4 21098092 1561804 Positive_regulation TNF TLR4 21159162 1696971 Positive_regulation TNF TLR4 21188217 1081608 Positive_regulation TNF TLR4 21188218 1081646 Positive_regulation TNF TLR4 21483834 2512377 Positive_regulation TNF TLR4 21556316 1078177 Positive_regulation TNF TLR4 21762537 3214228 Positive_regulation TNF TLR4 21789039 979894 Positive_regulation TNF TLR4 21829730 2542552 Positive_regulation TNF TLR4 21829730 2542572 Positive_regulation TNF TLR4 21852947 3052890 Positive_regulation TNF TLR4 21861860 123675 Positive_regulation TNF TLR4 21915309 2553177 Positive_regulation TNF TLR4 21915309 2553178 Positive_regulation TNF TLR4 21962237 354703 Positive_regulation TNF TLR4 21962237 354705 Positive_regulation TNF TLR4 21962237 354707 Positive_regulation TNF TLR4 21966468 2559051 Positive_regulation TNF TLR4 22069546 3181526 Positive_regulation TNF TLR4 22110383 1058500 Positive_regulation TNF TLR4 22115311 1697983 Positive_regulation TNF TLR4 22184119 1200870 Positive_regulation TNF TLR4 22225630 124576 Positive_regulation TNF TLR4 22225630 124577 Positive_regulation TNF TLR4 22277195 1660775 Positive_regulation TNF TLR4 22319556 2595423 Positive_regulation TNF TLR4 22434667 1050241 Positive_regulation TNF TLR4 22461749 3229288 Positive_regulation TNF TLR4 22484733 1957111 Positive_regulation TNF TLR4 22484733 1957182 Positive_regulation TNF TLR4 22513098 125413 Positive_regulation TNF TLR4 22523644 1680575 Positive_regulation TNF TLR4 22556042 1050647 Positive_regulation TNF TLR4 22556042 1050673 Positive_regulation TNF TLR4 22556042 1050705 Positive_regulation TNF TLR4 22563397 2626265 Positive_regulation TNF TLR4 22566960 900523 Positive_regulation TNF TLR4 22661952 957401 Positive_regulation TNF TLR4 22661952 957420 Positive_regulation TNF TLR4 22685622 2224299 Positive_regulation TNF TLR4 22734582 126369 Positive_regulation TNF TLR4 22754655 3221181 Positive_regulation TNF TLR4 22808176 2664960 Positive_regulation TNF TLR4 22808181 2665017 Positive_regulation TNF TLR4 22808181 2665038 Positive_regulation TNF TLR4 22829768 3058176 Positive_regulation TNF TLR4 22876243 902867 Positive_regulation TNF TLR4 22883744 1664709 Positive_regulation TNF TLR4 22916300 2680744 Positive_regulation TNF TLR4 22951730 1631219 Positive_regulation TNF TLR4 22951730 1631370 Positive_regulation TNF TLR4 23028609 2691894 Positive_regulation TNF TLR4 23049242 1224910 Positive_regulation TNF TLR4 23056417 2701500 Positive_regulation TNF TLR4 23071254 1569602 Positive_regulation TNF TLR4 23097717 1152856 Positive_regulation TNF TLR4 23118784 816063 Positive_regulation TNF TLR4 23186369 1665166 Positive_regulation TNF TLR4 23189060 960289 Positive_regulation TNF TLR4 23209568 2722491 Positive_regulation TNF TLR4 23239947 3229347 Positive_regulation TNF TLR4 23398888 342742 Positive_regulation TNF TLR4 23526966 2769113 Positive_regulation TNF TLR4 23557436 359057 Positive_regulation TNF TLR4 23638088 2787589 Positive_regulation TNF TLR4 23724117 2799026 Positive_regulation TNF TLR4 23724117 2799030 Positive_regulation TNF TLR4 23762040 980673 Positive_regulation TNF TLR4 23762102 819849 Positive_regulation TNF TLR4 23762102 819852 Positive_regulation TNF TLR4 23787171 1666830 Positive_regulation TNF TLR4 23799152 2807290 Positive_regulation TNF TLR4 23799152 2807412 Positive_regulation TNF TLR4 23799152 2807490 Positive_regulation TNF TLR4 23800014 1232200 Positive_regulation TNF TLR4 23835343 727914 Positive_regulation TNF TLR4 23864765 1754260 Positive_regulation TNF TLR4 23874444 2821342 Positive_regulation TNF TLR4 23898332 908465 Positive_regulation TNF TLR4 23935250 1754395 Positive_regulation TNF TLR4 23935250 1754401 Positive_regulation TNF TLR4 23935651 638086 Positive_regulation TNF TLR4 23935651 638118 Positive_regulation TNF TLR4 23936458 2831022 Positive_regulation TNF TLR4 23951210 2833738 Positive_regulation TNF TLR4 23959031 3217810 Positive_regulation TNF TLR4 23984304 1072180 Positive_regulation TNF TLR4 24058791 1705779 Positive_regulation TNF TLR4 24069456 2853356 Positive_regulation TNF TLR4 24083053 3175366 Positive_regulation TNF TLR4 24086560 2854647 Positive_regulation TNF TLR4 24165011 3123851 Positive_regulation TNF TLR4 24205068 2875177 Positive_regulation TNF TLR4 24205328 2875966 Positive_regulation TNF TLR4 24205328 2876011 Positive_regulation TNF TLR4 24205328 2876029 Positive_regulation TNF TLR4 24282429 639148 Positive_regulation TNF TLR4 24335753 3186510 Positive_regulation TNF TLR4 24335753 3186511 Positive_regulation TNF TLR4 24348797 843957 Positive_regulation TNF TLR4 24391503 3065889 Positive_regulation TNF TLR4 24400890 1482472 Positive_regulation TNF TLR4 24400890 1482495 Positive_regulation TNF TLR4 24409430 1498614 Positive_regulation TNF TLR4 24479879 538922 Positive_regulation TNF TLR4 24489448 1757433 Positive_regulation TNF TLR4 24489660 2915580 Positive_regulation TNF TLR4 24489933 2916919 Positive_regulation TNF TLR4 24586553 2925435 Positive_regulation TNF TLR4 24595131 2930816 Positive_regulation TNF TLR4 24609617 1050559 Positive_regulation TNF TLR4 24672653 1024312 Positive_regulation TNF TLR4 24733601 88648 Positive_regulation TNF TLR4 24734221 865066 Positive_regulation TNF TLR4 24743542 2955619 Positive_regulation TNF TLR4 24755612 2957123 Positive_regulation TNF TLR4 24758719 1483091 Positive_regulation TNF TLR4 24824830 2969465 Positive_regulation TNF TLR4 24829682 1769051 Positive_regulation TNF TLR4 24904418 954498 Positive_regulation TNF TLR4 24904418 954499 Positive_regulation TNF TLR4 24904418 954510 Positive_regulation TNF TLR4 24988481 2986296 Positive_regulation TNF TLR4 25004159 2987241 Positive_regulation TNF TLR4 25025559 1162051 Positive_regulation TNF TLR4 25053922 1627927 Positive_regulation TNF TLR4 25062998 1620040 Positive_regulation TNF TLR4 25071732 927010 Positive_regulation TNF TLR4 25071732 927061 Positive_regulation TNF TLR4 25078879 660730 Positive_regulation TNF TLR4 25093709 34262 Positive_regulation TNF TLR4 25093709 34286 Positive_regulation TNF TLR4 25101057 881027 Positive_regulation TNF TLR4 25120576 826628 Positive_regulation TNF TLR4 25120616 844879 Positive_regulation TNF TLR4 25133189 196823 Positive_regulation TNF TLR4 25136402 655428 Positive_regulation TNF TLR4 25161655 913879 Positive_regulation TNF TLR4 25165887 3069086 Positive_regulation TNF TLR4 25170305 1063326 Positive_regulation TNF TLR4 25222785 1045981 Positive_regulation TNF TLR4 25238061 3008347 Positive_regulation TNF TLR4 25295753 3012724 Positive_regulation TNF TLR4 25295753 3012765 Positive_regulation TNF TLR4 25329467 3016107 Positive_regulation TNF TLR4 25360682 3021147 Positive_regulation TNF TLR4 25371910 1623352 Positive_regulation TNF TLR4 25371910 1623361 Positive_regulation TNF TLR4 25530682 1763446 Positive_regulation TNF TLR4 25541965 3035930 Positive_regulation TNF TLR4 25550115 1734367 Positive_regulation TNF TLR4 25550115 1734391 Positive_regulation TNF TLR4 25580138 1703334 Positive_regulation TNF TLR4 25610471 3174579 Positive_regulation TNF TLR4 25615645 3038606 Positive_regulation TNF TLR4 PMC3242235 1702529 Positive_regulation TNF TLR5 12486107 1525650 Positive_regulation TNF TLR5 12719479 1526945 Positive_regulation TNF TLR5 16542467 105078 Positive_regulation TNF TLR5 17485511 1545603 Positive_regulation TNF TLR5 17850179 2263310 Positive_regulation TNF TLR5 17895997 2378753 Positive_regulation TNF TLR5 18195076 1548698 Positive_regulation TNF TLR5 18227218 1548829 Positive_regulation TNF TLR5 18411340 1550336 Positive_regulation TNF TLR5 18446192 2387900 Positive_regulation TNF TLR5 18493310 2389286 Positive_regulation TNF TLR5 18644971 1551614 Positive_regulation TNF TLR5 18779348 1551905 Positive_regulation TNF TLR5 19077314 1727823 Positive_regulation TNF TLR5 19183807 2405089 Positive_regulation TNF TLR5 19363483 1952372 Positive_regulation TNF TLR5 19386086 242374 Positive_regulation TNF TLR5 19386086 242394 Positive_regulation TNF TLR5 19386086 242422 Positive_regulation TNF TLR5 19419540 3117782 Positive_regulation TNF TLR5 19667063 1555773 Positive_regulation TNF TLR5 19668221 1952725 Positive_regulation TNF TLR5 20204070 1213905 Positive_regulation TNF TLR5 20584912 1377098 Positive_regulation TNF TLR5 20617179 3047832 Positive_regulation TNF TLR5 20644716 2455924 Positive_regulation TNF TLR5 20703784 1491327 Positive_regulation TNF TLR5 20706689 1747832 Positive_regulation TNF TLR5 20837769 1379090 Positive_regulation TNF TLR5 21098092 1561805 Positive_regulation TNF TLR5 21188217 1081609 Positive_regulation TNF TLR5 21188219 1081667 Positive_regulation TNF TLR5 21483834 2512372 Positive_regulation TNF TLR5 21483834 2512378 Positive_regulation TNF TLR5 21762537 3214229 Positive_regulation TNF TLR5 21789039 979895 Positive_regulation TNF TLR5 21829730 2542553 Positive_regulation TNF TLR5 21829730 2542573 Positive_regulation TNF TLR5 21852947 3052891 Positive_regulation TNF TLR5 21861860 123676 Positive_regulation TNF TLR5 21915309 2553179 Positive_regulation TNF TLR5 21915309 2553180 Positive_regulation TNF TLR5 22110383 1058501 Positive_regulation TNF TLR5 22277195 1660776 Positive_regulation TNF TLR5 22461749 3229289 Positive_regulation TNF TLR5 22484733 1957112 Positive_regulation TNF TLR5 22484733 1957183 Positive_regulation TNF TLR5 22513098 125414 Positive_regulation TNF TLR5 22523644 1680576 Positive_regulation TNF TLR5 22556042 1050648 Positive_regulation TNF TLR5 22556042 1050674 Positive_regulation TNF TLR5 22556042 1050706 Positive_regulation TNF TLR5 22754655 3221182 Positive_regulation TNF TLR5 22808181 2665039 Positive_regulation TNF TLR5 22829768 3058177 Positive_regulation TNF TLR5 22876243 902868 Positive_regulation TNF TLR5 22883744 1664710 Positive_regulation TNF TLR5 22916300 2680745 Positive_regulation TNF TLR5 23071254 1569603 Positive_regulation TNF TLR5 23239947 3229348 Positive_regulation TNF TLR5 23557436 359058 Positive_regulation TNF TLR5 23638088 2787590 Positive_regulation TNF TLR5 23787171 1666831 Positive_regulation TNF TLR5 23800014 1232201 Positive_regulation TNF TLR5 23898332 908466 Positive_regulation TNF TLR5 23935250 1754402 Positive_regulation TNF TLR5 23935651 638087 Positive_regulation TNF TLR5 23935651 638119 Positive_regulation TNF TLR5 23951210 2833739 Positive_regulation TNF TLR5 23959031 3217811 Positive_regulation TNF TLR5 24058791 1705780 Positive_regulation TNF TLR5 24069456 2853357 Positive_regulation TNF TLR5 24205068 2875178 Positive_regulation TNF TLR5 24205328 2875967 Positive_regulation TNF TLR5 24205328 2876030 Positive_regulation TNF TLR5 24282429 639149 Positive_regulation TNF TLR5 24409430 1498615 Positive_regulation TNF TLR5 24479879 538923 Positive_regulation TNF TLR5 24586553 2925436 Positive_regulation TNF TLR5 24609617 1050560 Positive_regulation TNF TLR5 24734221 865067 Positive_regulation TNF TLR5 24758719 1483092 Positive_regulation TNF TLR5 24824830 2969466 Positive_regulation TNF TLR5 25071732 927011 Positive_regulation TNF TLR5 25078879 660731 Positive_regulation TNF TLR5 25101057 881028 Positive_regulation TNF TLR5 25133189 196824 Positive_regulation TNF TLR5 25161655 913880 Positive_regulation TNF TLR5 25165887 3069087 Positive_regulation TNF TLR5 25222785 1045982 Positive_regulation TNF TLR5 25295753 3012725 Positive_regulation TNF TLR5 25295753 3012766 Positive_regulation TNF TLR5 25329467 3016108 Positive_regulation TNF TLR5 25377316 83983 Positive_regulation TNF TLR5 25377316 83984 Positive_regulation TNF TLR5 25377316 83989 Positive_regulation TNF TLR5 25530682 1763447 Positive_regulation TNF TLR5 25541965 3035931 Positive_regulation TNF TLR5 25550115 1734368 Positive_regulation TNF TLR5 25550115 1734392 Positive_regulation TNF TLR5 25615645 3038607 Positive_regulation TNF TLR5 PMC3242235 1702530 Positive_regulation TNF TLR6 12486107 1525655 Positive_regulation TNF TLR6 12719479 1526950 Positive_regulation TNF TLR6 16542467 105083 Positive_regulation TNF TLR6 17485511 1545608 Positive_regulation TNF TLR6 17850179 2263315 Positive_regulation TNF TLR6 17895997 2378758 Positive_regulation TNF TLR6 18195076 1548703 Positive_regulation TNF TLR6 18227218 1548834 Positive_regulation TNF TLR6 18411340 1550341 Positive_regulation TNF TLR6 18446192 2387905 Positive_regulation TNF TLR6 18493310 2389291 Positive_regulation TNF TLR6 18644971 1551619 Positive_regulation TNF TLR6 18779348 1551910 Positive_regulation TNF TLR6 19077314 1727828 Positive_regulation TNF TLR6 19183807 2405094 Positive_regulation TNF TLR6 19363483 1952377 Positive_regulation TNF TLR6 19386086 242379 Positive_regulation TNF TLR6 19386086 242399 Positive_regulation TNF TLR6 19386086 242427 Positive_regulation TNF TLR6 19419540 3117787 Positive_regulation TNF TLR6 19667063 1555778 Positive_regulation TNF TLR6 19668221 1952730 Positive_regulation TNF TLR6 20204070 1213910 Positive_regulation TNF TLR6 20584912 1377103 Positive_regulation TNF TLR6 20617179 3047837 Positive_regulation TNF TLR6 20644716 2455929 Positive_regulation TNF TLR6 20703784 1491332 Positive_regulation TNF TLR6 20706689 1747837 Positive_regulation TNF TLR6 20837769 1379095 Positive_regulation TNF TLR6 21098092 1561810 Positive_regulation TNF TLR6 21188217 1081614 Positive_regulation TNF TLR6 21762537 3214234 Positive_regulation TNF TLR6 21789039 979900 Positive_regulation TNF TLR6 21829730 2542558 Positive_regulation TNF TLR6 21829730 2542578 Positive_regulation TNF TLR6 21852947 3052896 Positive_regulation TNF TLR6 21861860 123681 Positive_regulation TNF TLR6 21915309 2553189 Positive_regulation TNF TLR6 21915309 2553190 Positive_regulation TNF TLR6 22110383 1058506 Positive_regulation TNF TLR6 22277195 1660781 Positive_regulation TNF TLR6 22461749 3229294 Positive_regulation TNF TLR6 22484733 1957117 Positive_regulation TNF TLR6 22484733 1957188 Positive_regulation TNF TLR6 22513098 125419 Positive_regulation TNF TLR6 22523644 1680581 Positive_regulation TNF TLR6 22556042 1050653 Positive_regulation TNF TLR6 22556042 1050679 Positive_regulation TNF TLR6 22556042 1050711 Positive_regulation TNF TLR6 22754655 3221187 Positive_regulation TNF TLR6 22808181 2665044 Positive_regulation TNF TLR6 22829768 3058183 Positive_regulation TNF TLR6 22876243 902873 Positive_regulation TNF TLR6 22883744 1664715 Positive_regulation TNF TLR6 22916300 2680750 Positive_regulation TNF TLR6 23071254 1569608 Positive_regulation TNF TLR6 23239947 3229353 Positive_regulation TNF TLR6 23271927 1714683 Positive_regulation TNF TLR6 23557436 359063 Positive_regulation TNF TLR6 23638088 2787595 Positive_regulation TNF TLR6 23787171 1666836 Positive_regulation TNF TLR6 23800014 1232206 Positive_regulation TNF TLR6 23898332 908471 Positive_regulation TNF TLR6 23935250 1754407 Positive_regulation TNF TLR6 23935651 638092 Positive_regulation TNF TLR6 23935651 638124 Positive_regulation TNF TLR6 23951210 2833744 Positive_regulation TNF TLR6 23959031 3217816 Positive_regulation TNF TLR6 24058791 1705785 Positive_regulation TNF TLR6 24069456 2853362 Positive_regulation TNF TLR6 24205068 2875183 Positive_regulation TNF TLR6 24205328 2875972 Positive_regulation TNF TLR6 24205328 2876035 Positive_regulation TNF TLR6 24282429 639154 Positive_regulation TNF TLR6 24409430 1498620 Positive_regulation TNF TLR6 24479879 538928 Positive_regulation TNF TLR6 24586553 2925441 Positive_regulation TNF TLR6 24609617 1050565 Positive_regulation TNF TLR6 24734221 865072 Positive_regulation TNF TLR6 24758719 1483097 Positive_regulation TNF TLR6 24824830 2969471 Positive_regulation TNF TLR6 24983999 2986009 Positive_regulation TNF TLR6 25071732 927016 Positive_regulation TNF TLR6 25078879 660736 Positive_regulation TNF TLR6 25101057 881033 Positive_regulation TNF TLR6 25133189 196829 Positive_regulation TNF TLR6 25161655 913885 Positive_regulation TNF TLR6 25165887 3069092 Positive_regulation TNF TLR6 25222785 1045987 Positive_regulation TNF TLR6 25295753 3012730 Positive_regulation TNF TLR6 25295753 3012771 Positive_regulation TNF TLR6 25329467 3016113 Positive_regulation TNF TLR6 25530682 1763452 Positive_regulation TNF TLR6 25541965 3035936 Positive_regulation TNF TLR6 25550115 1734373 Positive_regulation TNF TLR6 25550115 1734397 Positive_regulation TNF TLR6 25615645 3038612 Positive_regulation TNF TLR6 PMC3242235 1702535 Positive_regulation TNF TLR7 12486107 1525651 Positive_regulation TNF TLR7 12719479 1526946 Positive_regulation TNF TLR7 16542467 105079 Positive_regulation TNF TLR7 17485511 1545604 Positive_regulation TNF TLR7 17850179 2263311 Positive_regulation TNF TLR7 17895997 2378754 Positive_regulation TNF TLR7 18195076 1548699 Positive_regulation TNF TLR7 18227218 1548830 Positive_regulation TNF TLR7 18411340 1550337 Positive_regulation TNF TLR7 18446192 2387901 Positive_regulation TNF TLR7 18493310 2389287 Positive_regulation TNF TLR7 18644971 1551615 Positive_regulation TNF TLR7 18779348 1551906 Positive_regulation TNF TLR7 19077314 1727824 Positive_regulation TNF TLR7 19183807 2405090 Positive_regulation TNF TLR7 19325820 1087882 Positive_regulation TNF TLR7 19363483 1952373 Positive_regulation TNF TLR7 19386086 242375 Positive_regulation TNF TLR7 19386086 242395 Positive_regulation TNF TLR7 19386086 242411 Positive_regulation TNF TLR7 19386086 242423 Positive_regulation TNF TLR7 19419540 3117783 Positive_regulation TNF TLR7 19424421 3043794 Positive_regulation TNF TLR7 19667063 1555774 Positive_regulation TNF TLR7 19668221 1952726 Positive_regulation TNF TLR7 20098705 2437916 Positive_regulation TNF TLR7 20204070 1213906 Positive_regulation TNF TLR7 20584912 1377099 Positive_regulation TNF TLR7 20617179 3047833 Positive_regulation TNF TLR7 20644716 2455925 Positive_regulation TNF TLR7 20703784 1491328 Positive_regulation TNF TLR7 20706689 1747833 Positive_regulation TNF TLR7 20837769 1379091 Positive_regulation TNF TLR7 21098092 1561806 Positive_regulation TNF TLR7 21115688 1562047 Positive_regulation TNF TLR7 21115688 1562059 Positive_regulation TNF TLR7 21188217 1081610 Positive_regulation TNF TLR7 21556316 1078207 Positive_regulation TNF TLR7 21762537 3214230 Positive_regulation TNF TLR7 21789039 979896 Positive_regulation TNF TLR7 21829730 2542554 Positive_regulation TNF TLR7 21829730 2542574 Positive_regulation TNF TLR7 21852947 3052892 Positive_regulation TNF TLR7 21861860 123677 Positive_regulation TNF TLR7 21915309 2553181 Positive_regulation TNF TLR7 21915309 2553182 Positive_regulation TNF TLR7 22110383 1058502 Positive_regulation TNF TLR7 22243920 357084 Positive_regulation TNF TLR7 22277195 1660777 Positive_regulation TNF TLR7 22461749 3229290 Positive_regulation TNF TLR7 22484733 1957113 Positive_regulation TNF TLR7 22484733 1957184 Positive_regulation TNF TLR7 22513098 125415 Positive_regulation TNF TLR7 22523644 1680577 Positive_regulation TNF TLR7 22530722 3210217 Positive_regulation TNF TLR7 22556042 1050649 Positive_regulation TNF TLR7 22556042 1050675 Positive_regulation TNF TLR7 22556042 1050707 Positive_regulation TNF TLR7 22606294 2643006 Positive_regulation TNF TLR7 22691272 126163 Positive_regulation TNF TLR7 22754655 3221183 Positive_regulation TNF TLR7 22808181 2665040 Positive_regulation TNF TLR7 22829768 3058179 Positive_regulation TNF TLR7 22876243 902869 Positive_regulation TNF TLR7 22883744 1664711 Positive_regulation TNF TLR7 22916300 2680746 Positive_regulation TNF TLR7 23028609 2691851 Positive_regulation TNF TLR7 23071254 1569604 Positive_regulation TNF TLR7 23197922 88259 Positive_regulation TNF TLR7 23239947 3229349 Positive_regulation TNF TLR7 23396449 2085550 Positive_regulation TNF TLR7 23506673 1036583 Positive_regulation TNF TLR7 23557436 359059 Positive_regulation TNF TLR7 23638088 2787591 Positive_regulation TNF TLR7 23787171 1666832 Positive_regulation TNF TLR7 23800014 1232202 Positive_regulation TNF TLR7 23826189 2810724 Positive_regulation TNF TLR7 23826189 2810744 Positive_regulation TNF TLR7 23898332 908467 Positive_regulation TNF TLR7 23935250 1754403 Positive_regulation TNF TLR7 23935651 638088 Positive_regulation TNF TLR7 23935651 638120 Positive_regulation TNF TLR7 23951210 2833740 Positive_regulation TNF TLR7 23959031 3217812 Positive_regulation TNF TLR7 24058791 1705781 Positive_regulation TNF TLR7 24069456 2853358 Positive_regulation TNF TLR7 24191131 1754982 Positive_regulation TNF TLR7 24191131 1754995 Positive_regulation TNF TLR7 24205068 2875179 Positive_regulation TNF TLR7 24205328 2875968 Positive_regulation TNF TLR7 24205328 2876031 Positive_regulation TNF TLR7 24282429 639150 Positive_regulation TNF TLR7 24409430 1498616 Positive_regulation TNF TLR7 24479879 538924 Positive_regulation TNF TLR7 24533162 2922413 Positive_regulation TNF TLR7 24533162 2922416 Positive_regulation TNF TLR7 24533162 2922420 Positive_regulation TNF TLR7 24586553 2925437 Positive_regulation TNF TLR7 24609617 1050561 Positive_regulation TNF TLR7 24734221 865068 Positive_regulation TNF TLR7 24758719 1483093 Positive_regulation TNF TLR7 24824830 2969467 Positive_regulation TNF TLR7 25071732 927012 Positive_regulation TNF TLR7 25071732 927114 Positive_regulation TNF TLR7 25078879 660732 Positive_regulation TNF TLR7 25101057 881029 Positive_regulation TNF TLR7 25133189 196825 Positive_regulation TNF TLR7 25161655 913881 Positive_regulation TNF TLR7 25165887 3069088 Positive_regulation TNF TLR7 25222785 1045983 Positive_regulation TNF TLR7 25295753 3012726 Positive_regulation TNF TLR7 25295753 3012767 Positive_regulation TNF TLR7 25329467 3016109 Positive_regulation TNF TLR7 25485543 3032613 Positive_regulation TNF TLR7 25530682 1763448 Positive_regulation TNF TLR7 25541965 3035932 Positive_regulation TNF TLR7 25550115 1734369 Positive_regulation TNF TLR7 25550115 1734393 Positive_regulation TNF TLR7 25615645 3038608 Positive_regulation TNF TLR7 PMC3242235 1702531 Positive_regulation TNF TLR8 12486107 1525652 Positive_regulation TNF TLR8 12719479 1526947 Positive_regulation TNF TLR8 16542467 105080 Positive_regulation TNF TLR8 17485511 1545605 Positive_regulation TNF TLR8 17850179 2263312 Positive_regulation TNF TLR8 17895997 2378755 Positive_regulation TNF TLR8 18195076 1548700 Positive_regulation TNF TLR8 18227218 1548831 Positive_regulation TNF TLR8 18411340 1550338 Positive_regulation TNF TLR8 18446192 2387902 Positive_regulation TNF TLR8 18493310 2389288 Positive_regulation TNF TLR8 18644971 1551616 Positive_regulation TNF TLR8 18779348 1551907 Positive_regulation TNF TLR8 19077314 1727825 Positive_regulation TNF TLR8 19183807 2405091 Positive_regulation TNF TLR8 19363483 1952374 Positive_regulation TNF TLR8 19386086 242376 Positive_regulation TNF TLR8 19386086 242396 Positive_regulation TNF TLR8 19386086 242424 Positive_regulation TNF TLR8 19419540 3117784 Positive_regulation TNF TLR8 19667063 1555775 Positive_regulation TNF TLR8 19668221 1952727 Positive_regulation TNF TLR8 20204070 1213907 Positive_regulation TNF TLR8 20584912 1377100 Positive_regulation TNF TLR8 20617179 3047834 Positive_regulation TNF TLR8 20644716 2455926 Positive_regulation TNF TLR8 20703784 1491329 Positive_regulation TNF TLR8 20706689 1747834 Positive_regulation TNF TLR8 20837769 1379092 Positive_regulation TNF TLR8 20946625 3111373 Positive_regulation TNF TLR8 21098092 1561807 Positive_regulation TNF TLR8 21188217 1081611 Positive_regulation TNF TLR8 21203477 3050258 Positive_regulation TNF TLR8 21762537 3214231 Positive_regulation TNF TLR8 21789039 979897 Positive_regulation TNF TLR8 21829730 2542555 Positive_regulation TNF TLR8 21829730 2542575 Positive_regulation TNF TLR8 21852947 3052893 Positive_regulation TNF TLR8 21861860 123678 Positive_regulation TNF TLR8 21915309 2553183 Positive_regulation TNF TLR8 21915309 2553184 Positive_regulation TNF TLR8 21962237 354709 Positive_regulation TNF TLR8 22110383 1058503 Positive_regulation TNF TLR8 22277195 1660778 Positive_regulation TNF TLR8 22461749 3229291 Positive_regulation TNF TLR8 22474436 980102 Positive_regulation TNF TLR8 22484733 1957114 Positive_regulation TNF TLR8 22484733 1957185 Positive_regulation TNF TLR8 22513098 125416 Positive_regulation TNF TLR8 22523644 1680578 Positive_regulation TNF TLR8 22556042 1050650 Positive_regulation TNF TLR8 22556042 1050676 Positive_regulation TNF TLR8 22556042 1050708 Positive_regulation TNF TLR8 22691272 126164 Positive_regulation TNF TLR8 22754655 3221184 Positive_regulation TNF TLR8 22808181 2665041 Positive_regulation TNF TLR8 22829768 3058180 Positive_regulation TNF TLR8 22876243 902870 Positive_regulation TNF TLR8 22883744 1664712 Positive_regulation TNF TLR8 22916300 2680747 Positive_regulation TNF TLR8 23071254 1569605 Positive_regulation TNF TLR8 23239947 3229350 Positive_regulation TNF TLR8 23516559 2768464 Positive_regulation TNF TLR8 23557436 359060 Positive_regulation TNF TLR8 23638088 2787592 Positive_regulation TNF TLR8 23787171 1666833 Positive_regulation TNF TLR8 23800014 1232203 Positive_regulation TNF TLR8 23898332 908468 Positive_regulation TNF TLR8 23935250 1754404 Positive_regulation TNF TLR8 23935651 638089 Positive_regulation TNF TLR8 23935651 638121 Positive_regulation TNF TLR8 23951210 2833741 Positive_regulation TNF TLR8 23959031 3217813 Positive_regulation TNF TLR8 24058791 1705782 Positive_regulation TNF TLR8 24069456 2853359 Positive_regulation TNF TLR8 24205068 2875180 Positive_regulation TNF TLR8 24205328 2875969 Positive_regulation TNF TLR8 24205328 2876032 Positive_regulation TNF TLR8 24228179 1497150 Positive_regulation TNF TLR8 24282429 639151 Positive_regulation TNF TLR8 24409430 1498617 Positive_regulation TNF TLR8 24474949 910924 Positive_regulation TNF TLR8 24479879 538925 Positive_regulation TNF TLR8 24533162 2922414 Positive_regulation TNF TLR8 24533162 2922417 Positive_regulation TNF TLR8 24533162 2922421 Positive_regulation TNF TLR8 24586553 2925438 Positive_regulation TNF TLR8 24609617 1050562 Positive_regulation TNF TLR8 24734221 865069 Positive_regulation TNF TLR8 24758719 1483094 Positive_regulation TNF TLR8 24824830 2969468 Positive_regulation TNF TLR8 25071732 927013 Positive_regulation TNF TLR8 25078879 660733 Positive_regulation TNF TLR8 25101057 881030 Positive_regulation TNF TLR8 25133189 196826 Positive_regulation TNF TLR8 25161655 913882 Positive_regulation TNF TLR8 25165887 3069089 Positive_regulation TNF TLR8 25222785 1045984 Positive_regulation TNF TLR8 25295753 3012727 Positive_regulation TNF TLR8 25295753 3012768 Positive_regulation TNF TLR8 25329467 3016110 Positive_regulation TNF TLR8 25530682 1763449 Positive_regulation TNF TLR8 25541965 3035933 Positive_regulation TNF TLR8 25550115 1734370 Positive_regulation TNF TLR8 25550115 1734394 Positive_regulation TNF TLR8 25615645 3038609 Positive_regulation TNF TLR8 PMC3242235 1702532 Positive_regulation TNF TLR9 12486107 1525653 Positive_regulation TNF TLR9 12719479 1526948 Positive_regulation TNF TLR9 15197227 1532925 Positive_regulation TNF TLR9 15197227 1532945 Positive_regulation TNF TLR9 15197227 1532971 Positive_regulation TNF TLR9 16542467 105081 Positive_regulation TNF TLR9 17485511 1545606 Positive_regulation TNF TLR9 17850179 2263313 Positive_regulation TNF TLR9 17895997 2378756 Positive_regulation TNF TLR9 18195076 1548701 Positive_regulation TNF TLR9 18227218 1548832 Positive_regulation TNF TLR9 18411340 1550339 Positive_regulation TNF TLR9 18446192 2387903 Positive_regulation TNF TLR9 18493310 2389289 Positive_regulation TNF TLR9 18644971 1551617 Positive_regulation TNF TLR9 18779348 1551908 Positive_regulation TNF TLR9 19077314 1727826 Positive_regulation TNF TLR9 19183807 2405092 Positive_regulation TNF TLR9 19363483 1952375 Positive_regulation TNF TLR9 19386086 242377 Positive_regulation TNF TLR9 19386086 242397 Positive_regulation TNF TLR9 19386086 242412 Positive_regulation TNF TLR9 19386086 242425 Positive_regulation TNF TLR9 19419540 3117785 Positive_regulation TNF TLR9 19476613 113408 Positive_regulation TNF TLR9 19515231 3109640 Positive_regulation TNF TLR9 19667063 1555776 Positive_regulation TNF TLR9 19668221 1952728 Positive_regulation TNF TLR9 20145703 1213508 Positive_regulation TNF TLR9 20204070 1213908 Positive_regulation TNF TLR9 20360853 2444894 Positive_regulation TNF TLR9 20584912 1377101 Positive_regulation TNF TLR9 20617179 3047835 Positive_regulation TNF TLR9 20644716 2455927 Positive_regulation TNF TLR9 20703784 1491330 Positive_regulation TNF TLR9 20706689 1747835 Positive_regulation TNF TLR9 20837769 1379093 Positive_regulation TNF TLR9 20843814 1188513 Positive_regulation TNF TLR9 21098092 1561808 Positive_regulation TNF TLR9 21115688 1562048 Positive_regulation TNF TLR9 21115688 1562073 Positive_regulation TNF TLR9 21115691 1562136 Positive_regulation TNF TLR9 21115691 1562140 Positive_regulation TNF TLR9 21115691 1562146 Positive_regulation TNF TLR9 21188217 1081612 Positive_regulation TNF TLR9 21762537 3214232 Positive_regulation TNF TLR9 21789039 979898 Positive_regulation TNF TLR9 21829730 2542556 Positive_regulation TNF TLR9 21829730 2542576 Positive_regulation TNF TLR9 21852947 3052894 Positive_regulation TNF TLR9 21861860 123679 Positive_regulation TNF TLR9 21915309 2553185 Positive_regulation TNF TLR9 21915309 2553186 Positive_regulation TNF TLR9 22110383 1058504 Positive_regulation TNF TLR9 22277195 1660779 Positive_regulation TNF TLR9 22461749 3229292 Positive_regulation TNF TLR9 22484733 1957115 Positive_regulation TNF TLR9 22484733 1957186 Positive_regulation TNF TLR9 22513098 125417 Positive_regulation TNF TLR9 22523644 1680579 Positive_regulation TNF TLR9 22556042 1050651 Positive_regulation TNF TLR9 22556042 1050677 Positive_regulation TNF TLR9 22556042 1050709 Positive_regulation TNF TLR9 22719247 3057133 Positive_regulation TNF TLR9 22754655 3221185 Positive_regulation TNF TLR9 22808181 2665042 Positive_regulation TNF TLR9 22829768 3058181 Positive_regulation TNF TLR9 22876243 902871 Positive_regulation TNF TLR9 22883744 1664713 Positive_regulation TNF TLR9 22916300 2680748 Positive_regulation TNF TLR9 23071254 1569606 Positive_regulation TNF TLR9 23239947 3229351 Positive_regulation TNF TLR9 23396449 2085551 Positive_regulation TNF TLR9 23452377 356211 Positive_regulation TNF TLR9 23482058 2117256 Positive_regulation TNF TLR9 23557436 359061 Positive_regulation TNF TLR9 23638088 2787593 Positive_regulation TNF TLR9 23690658 1751920 Positive_regulation TNF TLR9 23787171 1666834 Positive_regulation TNF TLR9 23800014 1232204 Positive_regulation TNF TLR9 23826189 2810725 Positive_regulation TNF TLR9 23844808 314569 Positive_regulation TNF TLR9 23898332 908469 Positive_regulation TNF TLR9 23935250 1754405 Positive_regulation TNF TLR9 23935651 638090 Positive_regulation TNF TLR9 23935651 638122 Positive_regulation TNF TLR9 23951210 2833742 Positive_regulation TNF TLR9 23959031 3217814 Positive_regulation TNF TLR9 24058791 1705783 Positive_regulation TNF TLR9 24069456 2853360 Positive_regulation TNF TLR9 24083053 3175367 Positive_regulation TNF TLR9 24205068 2875181 Positive_regulation TNF TLR9 24205328 2875970 Positive_regulation TNF TLR9 24205328 2876033 Positive_regulation TNF TLR9 24228179 1497151 Positive_regulation TNF TLR9 24282429 639152 Positive_regulation TNF TLR9 24409430 1498618 Positive_regulation TNF TLR9 24479879 538926 Positive_regulation TNF TLR9 24498172 2918808 Positive_regulation TNF TLR9 24535292 1087124 Positive_regulation TNF TLR9 24586553 2925439 Positive_regulation TNF TLR9 24608170 2932689 Positive_regulation TNF TLR9 24609617 1050563 Positive_regulation TNF TLR9 24734221 865070 Positive_regulation TNF TLR9 24758719 1483095 Positive_regulation TNF TLR9 24824830 2969469 Positive_regulation TNF TLR9 25071732 927014 Positive_regulation TNF TLR9 25071732 927062 Positive_regulation TNF TLR9 25078879 660734 Positive_regulation TNF TLR9 25101057 881031 Positive_regulation TNF TLR9 25133189 196827 Positive_regulation TNF TLR9 25161655 913883 Positive_regulation TNF TLR9 25165887 3069090 Positive_regulation TNF TLR9 25170774 3003923 Positive_regulation TNF TLR9 25222785 1045985 Positive_regulation TNF TLR9 25279834 3012225 Positive_regulation TNF TLR9 25295753 3012728 Positive_regulation TNF TLR9 25295753 3012769 Positive_regulation TNF TLR9 25329467 3016111 Positive_regulation TNF TLR9 25530682 1763450 Positive_regulation TNF TLR9 25541965 3035934 Positive_regulation TNF TLR9 25550115 1734371 Positive_regulation TNF TLR9 25550115 1734395 Positive_regulation TNF TLR9 25615645 3038610 Positive_regulation TNF TLR9 PMC3242235 1702533 Positive_regulation TNF TMA16 16796737 1670716 Positive_regulation TNF TMA7 16796737 1670717 Positive_regulation TNF TMC8 23429285 559989 Positive_regulation TNF TMEM11 12676602 791621 Positive_regulation TNF TMEM11 12676602 791622 Positive_regulation TNF TNC 21818551 600221 Positive_regulation TNF TNC 23193984 127503 Positive_regulation TNF TNFAIP2 22912673 2677290 Positive_regulation TNF TNFAIP3 19169254 1948683 Positive_regulation TNF TNFAIP3 20617138 1215571 Positive_regulation TNF TNFAIP3 21345237 3213941 Positive_regulation TNF TNFAIP3 22031828 2565230 Positive_regulation TNF TNFAIP3 22654485 1224268 Positive_regulation TNF TNFAIP3 22958952 1920502 Positive_regulation TNF TNFAIP3 22979947 406937 Positive_regulation TNF TNFAIP3 23134590 482621 Positive_regulation TNF TNFAIP3 24069534 140856 Positive_regulation TNF TNFAIP3 24489933 2916967 Positive_regulation TNF TNFAIP3 24971461 2984391 Positive_regulation TNF TNFAIP6 22452753 1661438 Positive_regulation TNF TNFAIP8 24137373 2165642 Positive_regulation TNF TNFRSF11B 10637272 1514148 Positive_regulation TNF TNFRSF11B 16147974 1537125 Positive_regulation TNF TNFRSF11B PMC2833857 134382 Positive_regulation TNF TNFRSF1A 11667965 3102805 Positive_regulation TNF TNFRSF1A 12177785 421987 Positive_regulation TNF TNFRSF1A 16518473 3039114 Positive_regulation TNF TNFRSF1A 17383656 1143487 Positive_regulation TNF TNFRSF1A 18190721 1646122 Positive_regulation TNF TNFRSF1A 18250193 1548973 Positive_regulation TNF TNFRSF1A 19781631 613143 Positive_regulation TNF TNFRSF1A 20087353 434418 Positive_regulation TNF TNFRSF1A 20463965 2449866 Positive_regulation TNF TNFRSF1A 21475677 1238319 Positive_regulation TNF TNFRSF1A 21861862 123800 Positive_regulation TNF TNFRSF1A 22115362 212634 Positive_regulation TNF TNFRSF1A 22225778 469600 Positive_regulation TNF TNFRSF1A 22253841 2588191 Positive_regulation TNF TNFRSF1A 22919590 863383 Positive_regulation TNF TNFRSF1A 23328672 559003 Positive_regulation TNF TNFRSF1A 23328672 559004 Positive_regulation TNF TNFRSF1A 23328672 559026 Positive_regulation TNF TNFRSF1A 23493580 3175278 Positive_regulation TNF TNFRSF1A 23869211 2821098 Positive_regulation TNF TNFRSF1A 23869211 2821109 Positive_regulation TNF TNFRSF1A 23869211 2821114 Positive_regulation TNF TNFRSF1A 23903370 1709522 Positive_regulation TNF TNFRSF1A 24065916 973371 Positive_regulation TNF TNFRSF1A 24475180 2915176 Positive_regulation TNF TNFRSF1A 24587232 2929149 Positive_regulation TNF TNFRSF1A 24659953 869059 Positive_regulation TNF TNFRSF1A 25443631 762666 Positive_regulation TNF TNFRSF1A 25587544 1496823 Positive_regulation TNF TNFRSF1A 8145037 1594243 Positive_regulation TNF TNFRSF1A 8595164 445323 Positive_regulation TNF TNFRSF1A 8996244 1599834 Positive_regulation TNF TNFRSF1B 12177785 421988 Positive_regulation TNF TNFRSF1B 16385659 3230835 Positive_regulation TNF TNFRSF1B 18360633 3176737 Positive_regulation TNF TNFRSF1B 22110694 2572976 Positive_regulation TNF TNFRSF1B 23365678 2745494 Positive_regulation TNF TNFRSF1B 23840967 1154169 Positive_regulation TNF TNFRSF1B 23869211 2821099 Positive_regulation TNF TNFRSF1B 23869211 2821100 Positive_regulation TNF TNFRSF1B 23869211 2821110 Positive_regulation TNF TNFRSF1B 23869211 2821121 Positive_regulation TNF TNFRSF1B 24294006 1680280 Positive_regulation TNF TNFRSF1B 24627687 1070438 Positive_regulation TNF TNFRSF1B 24659953 869060 Positive_regulation TNF TNFRSF1B 24776599 514459 Positive_regulation TNF TNFRSF1B 25587544 1496824 Positive_regulation TNF TNFRSF1B 9348317 1601931 Positive_regulation TNF TNFRSF4 19707331 175423 Positive_regulation TNF TNFRSF6B 24453414 1756730 Positive_regulation TNF TNFRSF9 21747409 1041754 Positive_regulation TNF TNFRSF9 21747409 1041755 Positive_regulation TNF TNFRSF9 22039370 1038378 Positive_regulation TNF TNFRSF9 22039370 1038393 Positive_regulation TNF TNFRSF9 22039370 1038398 Positive_regulation TNF TNFRSF9 23316108 1751233 Positive_regulation TNF TNFRSF9 23437083 2755516 Positive_regulation TNF TNFSF10 18615196 3074426 Positive_regulation TNF TNFSF10 22194871 2583056 Positive_regulation TNF TNFSF10 PMC2833857 134383 Positive_regulation TNF TNFSF11 16669999 3107219 Positive_regulation TNF TNFSF11 17634140 108553 Positive_regulation TNF TNFSF11 18371213 110357 Positive_regulation TNF TNFSF11 19686583 116589 Positive_regulation TNF TNFSF11 21708014 123040 Positive_regulation TNF TNFSF11 22901757 126642 Positive_regulation TNF TNFSF11 23613773 2782247 Positive_regulation TNF TNFSF11 23936022 2829011 Positive_regulation TNF TNFSF11 24019592 3079926 Positive_regulation TNF TNFSF11 24151615 184543 Positive_regulation TNF TNFSF11 24324641 2890889 Positive_regulation TNF TNFSF11 24400116 2905772 Positive_regulation TNF TNFSF11 24719884 188823 Positive_regulation TNF TNFSF11 24837833 1126804 Positive_regulation TNF TNFSF11 PMC2833857 134384 Positive_regulation TNF TNFSF12 22394384 1661279 Positive_regulation TNF TNFSF12 23469193 2763145 Positive_regulation TNF TNFSF12 23752044 1632245 Positive_regulation TNF TNFSF12 23904741 163665 Positive_regulation TNF TNFSF12 24339827 910220 Positive_regulation TNF TNFSF13 20302641 118410 Positive_regulation TNF TNFSF13B 20302641 118411 Positive_regulation TNF TNFSF15 24416448 2909131 Positive_regulation TNF TNFSF15 24416448 2909132 Positive_regulation TNF TNFSF15 24416448 2909133 Positive_regulation TNF TNFSF15 24416448 2909151 Positive_regulation TNF TNFSF15 24416448 2909155 Positive_regulation TNF TNFSF15 24453414 1756735 Positive_regulation TNF TNFSF15 25148371 3001979 Positive_regulation TNF TNFSF15 25330517 3205491 Positive_regulation TNF TNFSF4 16275760 1538142 Positive_regulation TNF TNFSF4 16275760 1538143 Positive_regulation TNF TNFSF4 16275760 1538190 Positive_regulation TNF TNFSF4 16275760 1538216 Positive_regulation TNF TNFSF4 21339324 1562648 Positive_regulation TNF TNFSF4 PMC4288337 1623775 Positive_regulation TNF TNFSF9 23316108 1751234 Positive_regulation TNF TNIP1 19169254 1948684 Positive_regulation TNF TNIP1 22640752 126011 Positive_regulation TNF TNIP1 22654485 1224269 Positive_regulation TNF TNIP1 23448136 245394 Positive_regulation TNF TNIP2 22979947 406938 Positive_regulation TNF TNMD 24913232 1576593 Positive_regulation TNF TNP1 19124655 1553336 Positive_regulation TNF TNP2 19124655 1553337 Positive_regulation TNF TNPO1 11877479 1523096 Positive_regulation TNF TNPO1 20846396 353595 Positive_regulation TNF TNPO1 20846396 353601 Positive_regulation TNF TNPO1 20846396 353614 Positive_regulation TNF TNPO1 20846396 353615 Positive_regulation TNF TNPO1 21301926 1050346 Positive_regulation TNF TNR 19712456 1696372 Positive_regulation TNF TOP2A 22027829 1193617 Positive_regulation TNF TP53 17567906 370610 Positive_regulation TNF TP53 20406462 1853949 Positive_regulation TNF TP53 20406462 1853951 Positive_regulation TNF TP53 25258680 1675227 Positive_regulation TNF TP53INP1 19356238 113100 Positive_regulation TNF TP63 23945602 1729987 Positive_regulation TNF TPPP 20824074 2473606 Positive_regulation TNF TPX2 22547990 3152612 Positive_regulation TNF TRA 22864384 1727508 Positive_regulation TNF TRADD 23328672 559005 Positive_regulation TNF TRADD 23328672 559006 Positive_regulation TNF TRADD 23328672 559027 Positive_regulation TNF TRADD 23940775 2832353 Positive_regulation TNF TRAF1 20413583 2053218 Positive_regulation TNF TRAF2 12370254 1524971 Positive_regulation TNF TRAF2 19918265 609899 Positive_regulation TNF TRAF2 19918265 609927 Positive_regulation TNF TRAF2 19918265 609928 Positive_regulation TNF TRAF2 20413583 2053219 Positive_regulation TNF TRAF2 21119000 1783887 Positive_regulation TNF TRAF2 21119000 1783888 Positive_regulation TNF TRAF2 22111877 334698 Positive_regulation TNF TRAF2 22654913 1068285 Positive_regulation TNF TRAF2 9763618 1604547 Positive_regulation TNF TRAF3 20413583 2053220 Positive_regulation TNF TRAF3 21994750 3220020 Positive_regulation TNF TRAF3IP2 25071447 869885 Positive_regulation TNF TRAF4 20413583 2053221 Positive_regulation TNF TRAF5 20413583 2053222 Positive_regulation TNF TRAF5 23042150 1957917 Positive_regulation TNF TRAF6 11266466 1269167 Positive_regulation TNF TRAF6 18759964 111129 Positive_regulation TNF TRAF6 20100871 1557333 Positive_regulation TNF TRAF6 20413583 2053223 Positive_regulation TNF TRAF6 22249448 1566889 Positive_regulation TNF TRAF6 22496647 3056090 Positive_regulation TNF TRAF6 22496647 3056104 Positive_regulation TNF TRAF6 22654913 1068286 Positive_regulation TNF TRAF6 23762085 637542 Positive_regulation TNF TRAF6 23922952 2827746 Positive_regulation TNF TRAF6 23990781 3063840 Positive_regulation TNF TRAF7 20413583 2053224 Positive_regulation TNF TRAM1 24349012 2896596 Positive_regulation TNF TRAM2 24349012 2896595 Positive_regulation TNF TRAP1 11044363 418038 Positive_regulation TNF TRAPPC1 25126882 2998104 Positive_regulation TNF TREM1 23861562 1754184 Positive_regulation TNF TREM1 24453980 3066033 Positive_regulation TNF TREM1 25464008 3031238 Positive_regulation TNF TREM1 25505454 927424 Positive_regulation TNF TREM2 11828015 1522852 Positive_regulation TNF TREM2 22666624 1052906 Positive_regulation TNF TRIM3 23967238 2835174 Positive_regulation TNF TRIM31 23936368 2830199 Positive_regulation TNF TRIM63 23300968 2737662 Positive_regulation TNF TRIM8 23152791 2716284 Positive_regulation TNF TRIM8 23152791 2716286 Positive_regulation TNF TRPV1 19695100 1897435 Positive_regulation TNF TRPV1 19695100 1897436 Positive_regulation TNF TRPV1 19695100 1897437 Positive_regulation TNF TRPV1 19695100 1897445 Positive_regulation TNF TRPV1 19695100 1897449 Positive_regulation TNF TRPV2 20118928 1953495 Positive_regulation TNF TRPV4 19695100 1897438 Positive_regulation TNF TRPV4 19695100 1897439 Positive_regulation TNF TRPV4 19695100 1897450 Positive_regulation TNF TSHR 25452768 845427 Positive_regulation TNF TSLP 18724870 524846 Positive_regulation TNF TSLP 20230634 34405 Positive_regulation TNF TSLP 21339327 1562664 Positive_regulation TNF TSLP 22205837 1712056 Positive_regulation TNF TSLP 22354320 1918717 Positive_regulation TNF TSLP 25198676 3006123 Positive_regulation TNF TSLP 25546419 3036550 Positive_regulation TNF TSPAN31 23758654 3210509 Positive_regulation TNF TTN 15228623 523859 Positive_regulation TNF TYR 20308428 1373817 Positive_regulation TNF TYRP1 23013558 395940 Positive_regulation TNF UBE2N 20613989 2454655 Positive_regulation TNF UBE2V1 23922952 2827747 Positive_regulation TNF UCP2 15689240 2112204 Positive_regulation TNF UCP2 23826253 2811719 Positive_regulation TNF UFD1L 24821544 1126495 Positive_regulation TNF UPK3B 23700396 1039654 Positive_regulation TNF USP12 25071782 913474 Positive_regulation TNF USP25 23042150 1957918 Positive_regulation TNF UXT 21307340 1786588 Positive_regulation TNF UXT 21307340 1786597 Positive_regulation TNF VCAM1 10209034 1245466 Positive_regulation TNF VCAM1 11132773 1737238 Positive_regulation TNF VCAM1 12438420 1525219 Positive_regulation TNF VCAM1 12537603 3103819 Positive_regulation TNF VCAM1 1281211 1527736 Positive_regulation TNF VCAM1 12875662 247416 Positive_regulation TNF VCAM1 12875662 247420 Positive_regulation TNF VCAM1 1370496 1297710 Positive_regulation TNF VCAM1 15483345 1634368 Positive_regulation TNF VCAM1 16336680 656505 Positive_regulation TNF VCAM1 17383656 1143488 Positive_regulation TNF VCAM1 18366601 322481 Positive_regulation TNF VCAM1 18472842 1742224 Positive_regulation TNF VCAM1 19597294 736291 Positive_regulation TNF VCAM1 20181103 1625935 Positive_regulation TNF VCAM1 20386708 2446390 Positive_regulation TNF VCAM1 21264293 2495219 Positive_regulation TNF VCAM1 21403844 506730 Positive_regulation TNF VCAM1 21808585 1682051 Positive_regulation TNF VCAM1 21872249 139260 Positive_regulation TNF VCAM1 22529568 1675245 Positive_regulation TNF VCAM1 22615904 2644169 Positive_regulation TNF VCAM1 22734001 1398620 Positive_regulation TNF VCAM1 23285008 2731527 Positive_regulation TNF VCAM1 23690670 1752080 Positive_regulation TNF VCAM1 23895132 1726238 Positive_regulation TNF VCAM1 24069252 2852290 Positive_regulation TNF VCAM1 24098720 2859476 Positive_regulation TNF VCAM1 24106604 1764609 Positive_regulation TNF VCAM1 24228622 359339 Positive_regulation TNF VCAM1 24244812 204844 Positive_regulation TNF VCAM1 24470523 1159265 Positive_regulation TNF VCAM1 24516119 1575020 Positive_regulation TNF VCAM1 24583847 1124486 Positive_regulation TNF VCAM1 25025040 194658 Positive_regulation TNF VCAM1 7528776 1589762 Positive_regulation TNF VCAM1 7705312 796396 Positive_regulation TNF VCAN 11545252 1737861 Positive_regulation TNF VCAN 19087346 3109110 Positive_regulation TNF VCAN 22837669 1096334 Positive_regulation TNF VCAN 24213109 499406 Positive_regulation TNF VCP 19193236 365522 Positive_regulation TNF VCP 24821544 1126496 Positive_regulation TNF VEGFA 16622457 427499 Positive_regulation TNF VEGFA 17644552 90709 Positive_regulation TNF VEGFA 18202163 3177760 Positive_regulation TNF VEGFA 19325820 1087881 Positive_regulation TNF VEGFA 20029652 178129 Positive_regulation TNF VEGFA 20530741 714098 Positive_regulation TNF VEGFA 21756372 3112398 Positive_regulation TNF VEGFA 22394384 1661314 Positive_regulation TNF VEGFA 2258694 1568153 Positive_regulation TNF VEGFA 23213275 1915281 Positive_regulation TNF VEGFA 23285282 2733418 Positive_regulation TNF VEGFA 23646053 1714018 Positive_regulation TNF VEGFA 23895055 1869135 Positive_regulation TNF VEGFA 24286116 130148 Positive_regulation TNF VEGFA 24312355 2888941 Positive_regulation TNF VEGFA 24734240 188949 Positive_regulation TNF VEGFA 24940033 1917041 Positive_regulation TNF VEGFA 24940033 1917075 Positive_regulation TNF VEGFA 24998927 807001 Positive_regulation TNF VEGFA 25104881 1760297 Positive_regulation TNF VEGFA PMC128906 99439 Positive_regulation TNF VEGFC 23243599 2161895 Positive_regulation TNF VIM 20003262 1655809 Positive_regulation TNF VIM 21278075 3126174 Positive_regulation TNF VIMP 19193236 365524 Positive_regulation TNF VIP 14680506 99984 Positive_regulation TNF VIP 22328918 2595663 Positive_regulation TNF VIP 23723978 2798832 Positive_regulation TNF WDR61 1460427 1529593 Positive_regulation TNF WDR61 1460427 1529600 Positive_regulation TNF WDR61 1460427 1529605 Positive_regulation TNF WDR61 1460427 1529610 Positive_regulation TNF WDR61 16172262 1537888 Positive_regulation TNF WDR61 18472926 1743170 Positive_regulation TNF WDR61 19308689 495301 Positive_regulation TNF WDR61 19652714 2422679 Positive_regulation TNF WDR61 21082032 2482395 Positive_regulation TNF WDR61 21860543 1749376 Positive_regulation TNF WDR61 3119758 1580166 Positive_regulation TNF WDR61 7516414 1589297 Positive_regulation TNF WDR61 9836496 1764029 Positive_regulation TNF WISP1 23343403 127784 Positive_regulation TNF WISP1 23343403 127810 Positive_regulation TNF WNK1 20844082 1782656 Positive_regulation TNF WNK1 21904602 2550365 Positive_regulation TNF WNK1 22547990 3152613 Positive_regulation TNF WNK1 23593410 2781168 Positive_regulation TNF WNK1 23593410 2781179 Positive_regulation TNF WNK1 23762160 820144 Positive_regulation TNF WNK1 24130828 2867266 Positive_regulation TNF WNK1 24386331 2903475 Positive_regulation TNF WNK1 24800251 190144 Positive_regulation TNF WNK1 25022892 475311 Positive_regulation TNF WNK1 25121098 196514 Positive_regulation TNF WNK1 25201625 541042 Positive_regulation TNF WNK1 PMC3647302 651826 Positive_regulation TNF WNT1 24286133 130173 Positive_regulation TNF WNT1 24286133 130174 Positive_regulation TNF WNT1 24286133 130250 Positive_regulation TNF WNT1 24286133 130251 Positive_regulation TNF WNT1 24286133 130252 Positive_regulation TNF WNT1 24286133 130286 Positive_regulation TNF WNT1 24286133 130287 Positive_regulation TNF WNT1 24286133 130351 Positive_regulation TNF WNT1 24286133 130380 Positive_regulation TNF WNT10A 21203463 2490496 Positive_regulation TNF WNT11 24286133 130175 Positive_regulation TNF WNT11 24286133 130176 Positive_regulation TNF WNT11 24286133 130253 Positive_regulation TNF WNT11 24286133 130254 Positive_regulation TNF WNT11 24286133 130255 Positive_regulation TNF WNT11 24286133 130288 Positive_regulation TNF WNT11 24286133 130289 Positive_regulation TNF WNT11 24286133 130352 Positive_regulation TNF WNT11 24286133 130381 Positive_regulation TNF WNT16 24286133 130185 Positive_regulation TNF WNT16 24286133 130186 Positive_regulation TNF WNT16 24286133 130268 Positive_regulation TNF WNT16 24286133 130269 Positive_regulation TNF WNT16 24286133 130270 Positive_regulation TNF WNT16 24286133 130298 Positive_regulation TNF WNT16 24286133 130299 Positive_regulation TNF WNT16 24286133 130358 Positive_regulation TNF WNT16 24286133 130386 Positive_regulation TNF WNT2 24286133 130177 Positive_regulation TNF WNT2 24286133 130178 Positive_regulation TNF WNT2 24286133 130256 Positive_regulation TNF WNT2 24286133 130257 Positive_regulation TNF WNT2 24286133 130258 Positive_regulation TNF WNT2 24286133 130290 Positive_regulation TNF WNT2 24286133 130291 Positive_regulation TNF WNT2 24286133 130353 Positive_regulation TNF WNT2 24286133 130382 Positive_regulation TNF WNT3 24286133 130179 Positive_regulation TNF WNT3 24286133 130180 Positive_regulation TNF WNT3 24286133 130259 Positive_regulation TNF WNT3 24286133 130260 Positive_regulation TNF WNT3 24286133 130261 Positive_regulation TNF WNT3 24286133 130292 Positive_regulation TNF WNT3 24286133 130293 Positive_regulation TNF WNT3 24286133 130354 Positive_regulation TNF WNT3 24286133 130383 Positive_regulation TNF WNT4 24286133 130181 Positive_regulation TNF WNT4 24286133 130182 Positive_regulation TNF WNT4 24286133 130262 Positive_regulation TNF WNT4 24286133 130263 Positive_regulation TNF WNT4 24286133 130264 Positive_regulation TNF WNT4 24286133 130294 Positive_regulation TNF WNT4 24286133 130295 Positive_regulation TNF WNT4 24286133 130355 Positive_regulation TNF WNT4 24286133 130384 Positive_regulation TNF WNT5A 21857966 2544450 Positive_regulation TNF WNT5A 24993819 274219 Positive_regulation TNF WNT6 24286133 130183 Positive_regulation TNF WNT6 24286133 130184 Positive_regulation TNF WNT6 24286133 130265 Positive_regulation TNF WNT6 24286133 130266 Positive_regulation TNF WNT6 24286133 130267 Positive_regulation TNF WNT6 24286133 130296 Positive_regulation TNF WNT6 24286133 130297 Positive_regulation TNF WNT6 24286133 130356 Positive_regulation TNF WNT6 24286133 130385 Positive_regulation TNF WSN 23226456 2725081 Positive_regulation TNF WT1 20376191 2445263 Positive_regulation TNF WWOX 11960552 276599 Positive_regulation TNF WWOX 11960552 276608 Positive_regulation TNF WWOX 11960552 276626 Positive_regulation TNF WWOX 11960552 276629 Positive_regulation TNF WWOX 11960552 276631 Positive_regulation TNF WWOX 17567906 370592 Positive_regulation TNF WWOX 17567906 370611 Positive_regulation TNF WWOX 17567906 370612 Positive_regulation TNF WWOX 17567906 370635 Positive_regulation TNF WWOX 20658292 3126117 Positive_regulation TNF WWP1 23799152 2807291 Positive_regulation TNF WWP1 23799152 2807292 Positive_regulation TNF WWP1 23799152 2807455 Positive_regulation TNF WWP1 23799152 2807461 Positive_regulation TNF XCL1 20544034 2452619 Positive_regulation TNF XDH 21912722 2223916 Positive_regulation TNF XDH 23300968 2737747 Positive_regulation TNF XIAP 23437404 2756828 Positive_regulation TNF ZFP36 12823857 99884 Positive_regulation TNF ZFP36 15535838 101910 Positive_regulation TNF ZFP36 17392586 1741404 Positive_regulation TNF ZFP36 22186734 1904383 Positive_regulation TNF ZFP36 23468959 2760287 Positive_regulation TNF ZFP36 23468959 2760291 Positive_regulation TNF ZFP36 23468959 2760298 Positive_regulation TNF ZFP36 23905055 3188167 Positive_regulation TNF ZFP36 23940256 1573392 Positive_regulation TNF ZFP36 PMC2834070 134562 Positive_regulation TNFAIP2 PDLIM7 25367335 626598 Positive_regulation TNFAIP2 TNF 22912673 2677291 Positive_regulation TNFAIP2 TNF 25383966 3024576 Positive_regulation TNFAIP3 IL1B 24618842 2933383 Positive_regulation TNFAIP3 TNF 17052335 319216 Positive_regulation TNFAIP3 TNF 19060883 1983103 Positive_regulation TNFAIP3 TNF 19826422 432899 Positive_regulation TNFAIP3 TNF 19826422 432900 Positive_regulation TNFAIP3 TNF 21151899 2485267 Positive_regulation TNFAIP3 TNF 21345237 3213943 Positive_regulation TNFAIP3 TNF 21754991 2535248 Positive_regulation TNFAIP3 TNF 22031828 2565231 Positive_regulation TNFAIP3 TNF 22507528 1661611 Positive_regulation TNFAIP3 TNF 22654485 1224270 Positive_regulation TNFAIP3 TNF 22979947 406940 Positive_regulation TNFAIP3 TNF 23134590 482622 Positive_regulation TNFAIP3 TNF 24069534 140857 Positive_regulation TNFAIP3 TNF 24489933 2916968 Positive_regulation TNFAIP3 TNF 24595030 2930467 Positive_regulation TNFAIP3 TNF 24595242 1124984 Positive_regulation TNFAIP3 TNF 24690917 2947299 Positive_regulation TNFAIP3 TNF 24971461 2984423 Positive_regulation TNFAIP3 TNF 25071782 913480 Positive_regulation TNFAIP6 IL1B 25562599 3037240 Positive_regulation TNFAIP6 PLAU 24023701 2843335 Positive_regulation TNFAIP6 TNF 21569482 3169056 Positive_regulation TNFAIP6 TNF 22351758 1201284 Positive_regulation TNFAIP6 TNF 22452753 1661439 Positive_regulation TNFAIP6 TNF 22455445 336081 Positive_regulation TNFAIP6 TNF 23853610 3174103 Positive_regulation TNFAIP6 TNF 24000286 3174155 Positive_regulation TNFAIP6 TNF 25100155 3172286 Positive_regulation TNFAIP6 TNF 25190808 1210864 Positive_regulation TNFAIP8 TNF 24137373 2165643 Positive_regulation TNFAIP8 TNF 24577093 572606 Positive_regulation TNFRSF10A FAS 22087285 2571271 Positive_regulation TNFRSF10A MAP2K6 20673328 1857754 Positive_regulation TNFRSF10A TNF 20440001 1376063 Positive_regulation TNFRSF10A TNFSF10 15007095 1531784 Positive_regulation TNFRSF10A TNFSF10 15007095 1531849 Positive_regulation TNFRSF10A TNFSF10 16507116 104963 Positive_regulation TNFRSF10A TNFSF10 17953743 1848207 Positive_regulation TNFRSF10A TNFSF10 19892808 811613 Positive_regulation TNFRSF10A TNFSF10 20161998 1089231 Positive_regulation TNFRSF10A TNFSF10 21625476 2524180 Positive_regulation TNFRSF10A TNFSF10 21625476 2524192 Positive_regulation TNFRSF10A TNFSF10 23840967 1154144 Positive_regulation TNFRSF10A TNFSF10 24065163 1730219 Positive_regulation TNFRSF10A TNFSF10 24065163 1730300 Positive_regulation TNFRSF10A TNFSF10 24213315 499682 Positive_regulation TNFRSF10B EPHB2 24979133 1128069 Positive_regulation TNFRSF10B FAS 22084408 1566070 Positive_regulation TNFRSF10B FAS 22087285 2571273 Positive_regulation TNFRSF10B MAP2K6 20673328 1857761 Positive_regulation TNFRSF10B MUC16 24690311 272599 Positive_regulation TNFRSF10B TNFSF10 10224285 1511702 Positive_regulation TNFRSF10B TNFSF10 16361820 1634717 Positive_regulation TNFRSF10B TNFSF10 19892808 811614 Positive_regulation TNFRSF10B TNFSF10 20161998 1089232 Positive_regulation TNFRSF10B TNFSF10 21092273 1860257 Positive_regulation TNFRSF10B TNFSF10 21625476 2524181 Positive_regulation TNFRSF10B TNFSF10 21625476 2524193 Positive_regulation TNFRSF10B TNFSF10 21801359 260666 Positive_regulation TNFRSF10B TNFSF10 22084408 1566071 Positive_regulation TNFRSF10B TNFSF10 22110611 2572639 Positive_regulation TNFRSF10B TNFSF10 23840967 1154145 Positive_regulation TNFRSF10B TNFSF10 24065163 1730301 Positive_regulation TNFRSF10B TNFSF10 24979133 1128068 Positive_regulation TNFRSF10C TNFSF10 21092294 1860269 Positive_regulation TNFRSF10C TNFSF10 22213832 1882540 Positive_regulation TNFRSF10C TNFSF10 24086526 2854480 Positive_regulation TNFRSF10D TNFSF10 24086526 2854481 Positive_regulation TNFRSF10D TNFSF10 24481457 571857 Positive_regulation TNFRSF11B EPHB2 24265865 206068 Positive_regulation TNFRSF11B EPHB2 24267510 1678914 Positive_regulation TNFRSF11B TGM2 24265865 206053 Positive_regulation TNFRSF11B TGM2 24265865 206054 Positive_regulation TNFRSF11B TGM2 24265865 206055 Positive_regulation TNFRSF11B TGM2 24265865 206066 Positive_regulation TNFRSF11B TGM2 24265865 206080 Positive_regulation TNFRSF11B TNF 15142264 101186 Positive_regulation TNFRSF11B TNF 15642135 102291 Positive_regulation TNFRSF11B TNF 15642135 102295 Positive_regulation TNFRSF11B TNF 15642135 102298 Positive_regulation TNFRSF11B TNF 17963332 3231328 Positive_regulation TNFRSF11B TNF 17963332 3231337 Positive_regulation TNFRSF11B TNF 17963332 3231338 Positive_regulation TNFRSF11B TNF 17963332 3231339 Positive_regulation TNFRSF11B TNF 22157665 1734714 Positive_regulation TNFRSF11B TNF 22176920 3112880 Positive_regulation TNFRSF11B TNF 23146195 127233 Positive_regulation TNFRSF11B TNF 24228244 184962 Positive_regulation TNFRSF11B TNF 24683547 187702 Positive_regulation TNFRSF11B TNF 25259713 3010536 Positive_regulation TNFRSF11B TNF PMC2833857 134385 Positive_regulation TNFRSF12A TNF 20953353 1748398 Positive_regulation TNFRSF12A TNF 20967264 2478598 Positive_regulation TNFRSF13C TLR7 17664289 1546723 Positive_regulation TNFRSF1A FAS 22389673 2607919 Positive_regulation TNFRSF1A TNF 11667965 3102806 Positive_regulation TNFRSF1A TNF 16385659 3230837 Positive_regulation TNFRSF1A TNF 16385659 3230839 Positive_regulation TNFRSF1A TNF 16518473 3039116 Positive_regulation TNFRSF1A TNF 16696862 106017 Positive_regulation TNFRSF1A TNF 17383656 1143490 Positive_regulation TNFRSF1A TNF 18096615 2032365 Positive_regulation TNFRSF1A TNF 18190721 1646123 Positive_regulation TNFRSF1A TNF 19118493 651021 Positive_regulation TNFRSF1A TNF 19262463 764076 Positive_regulation TNFRSF1A TNF 19640296 325844 Positive_regulation TNFRSF1A TNF 19707369 175623 Positive_regulation TNFRSF1A TNF 19826422 432920 Positive_regulation TNFRSF1A TNF 19997621 2432997 Positive_regulation TNFRSF1A TNF 20194223 3126169 Positive_regulation TNFRSF1A TNF 20463965 2449867 Positive_regulation TNFRSF1A TNF 21152396 1912449 Positive_regulation TNFRSF1A TNF 21304825 2499969 Positive_regulation TNFRSF1A TNF 21324111 121482 Positive_regulation TNFRSF1A TNF 21738708 2533438 Positive_regulation TNFRSF1A TNF 21754991 2535243 Positive_regulation TNFRSF1A TNF 21789261 2538370 Positive_regulation TNFRSF1A TNF 21816064 508605 Positive_regulation TNFRSF1A TNF 21850048 552434 Positive_regulation TNFRSF1A TNF 21850048 552453 Positive_regulation TNFRSF1A TNF 21867555 1659536 Positive_regulation TNFRSF1A TNF 21871121 1659640 Positive_regulation TNFRSF1A TNF 21871121 1659642 Positive_regulation TNFRSF1A TNF 21978728 1892500 Positive_regulation TNFRSF1A TNF 22025971 85663 Positive_regulation TNFRSF1A TNF 22110694 2572974 Positive_regulation TNFRSF1A TNF 22654792 875825 Positive_regulation TNFRSF1A TNF 22919590 863384 Positive_regulation TNFRSF1A TNF 23202309 3184264 Positive_regulation TNFRSF1A TNF 23840967 1154146 Positive_regulation TNFRSF1A TNF 23840967 1154147 Positive_regulation TNFRSF1A TNF 23840967 1154148 Positive_regulation TNFRSF1A TNF 23840967 1154195 Positive_regulation TNFRSF1A TNF 23869211 2821103 Positive_regulation TNFRSF1A TNF 23869211 2821115 Positive_regulation TNFRSF1A TNF 23874808 2822920 Positive_regulation TNFRSF1A TNF 23918568 3233656 Positive_regulation TNFRSF1A TNF 24065916 973372 Positive_regulation TNFRSF1A TNF 24098720 2859475 Positive_regulation TNFRSF1A TNF 24098720 2859478 Positive_regulation TNFRSF1A TNF 24318359 2186061 Positive_regulation TNFRSF1A TNF 24318359 2186067 Positive_regulation TNFRSF1A TNF 24371374 1755984 Positive_regulation TNFRSF1A TNF 24502696 1233034 Positive_regulation TNFRSF1A TNF 24502696 1233214 Positive_regulation TNFRSF1A TNF 24587232 2929150 Positive_regulation TNFRSF1A TNF 24587232 2929151 Positive_regulation TNFRSF1A TNF 24595030 2930469 Positive_regulation TNFRSF1A TNF 24616552 1757553 Positive_regulation TNFRSF1A TNF 24743777 504227 Positive_regulation TNFRSF1A TNF 24966471 1759845 Positive_regulation TNFRSF1A TNF 25061812 2992432 Positive_regulation TNFRSF1A TNF 25228904 914176 Positive_regulation TNFRSF1A TNF 25431611 827038 Positive_regulation TNFRSF1A TNF 25493630 3033407 Positive_regulation TNFRSF1A TNF 25606044 746838 Positive_regulation TNFRSF1A TNF 8595164 445327 Positive_regulation TNFRSF1A TNF PMC3284948 395648 Positive_regulation TNFRSF1B FAS 17254331 166007 Positive_regulation TNFRSF1B NGFR 21519548 85484 Positive_regulation TNFRSF1B TNF 16385659 3230836 Positive_regulation TNFRSF1B TNF 16385659 3230840 Positive_regulation TNFRSF1B TNF 17362524 3116513 Positive_regulation TNFRSF1B TNF 18177511 109749 Positive_regulation TNFRSF1B TNF 18331642 1625048 Positive_regulation TNFRSF1B TNF 19065997 3208648 Positive_regulation TNFRSF1B TNF 19118493 651022 Positive_regulation TNFRSF1B TNF 19435506 113285 Positive_regulation TNFRSF1B TNF 20194223 3126170 Positive_regulation TNFRSF1B TNF 20463877 2291341 Positive_regulation TNFRSF1B TNF 21221075 1717674 Positive_regulation TNFRSF1B TNF 21324111 121483 Positive_regulation TNFRSF1B TNF 21754991 2535244 Positive_regulation TNFRSF1B TNF 21867555 1659537 Positive_regulation TNFRSF1B TNF 21871121 1659641 Positive_regulation TNFRSF1B TNF 22110694 2572977 Positive_regulation TNFRSF1B TNF 23760533 907538 Positive_regulation TNFRSF1B TNF 23840967 1154149 Positive_regulation TNFRSF1B TNF 23840967 1154170 Positive_regulation TNFRSF1B TNF 23840967 1154182 Positive_regulation TNFRSF1B TNF 23869211 2821102 Positive_regulation TNFRSF1B TNF 23869211 2821104 Positive_regulation TNFRSF1B TNF 23869211 2821120 Positive_regulation TNFRSF1B TNF 23869211 2821122 Positive_regulation TNFRSF1B TNF 23874808 2822921 Positive_regulation TNFRSF1B TNF 24350291 185949 Positive_regulation TNFRSF1B TNF 24371374 1755985 Positive_regulation TNFRSF1B TNF 24465047 694695 Positive_regulation TNFRSF1B TNF 24587232 2929152 Positive_regulation TNFRSF1B TNF 24587232 2929153 Positive_regulation TNFRSF1B TNF 25228904 914178 Positive_regulation TNFRSF1B TNF 8691131 1598223 Positive_regulation TNFRSF6B TNF 24453414 1756731 Positive_regulation TNFRSF9 EPHB2 23874982 2823948 Positive_regulation TNFRSF9 EPHB2 23874982 2823964 Positive_regulation TNFRSF9 TNF 23547098 1571024 Positive_regulation TNFRSF9 TNF 24023849 2843817 Positive_regulation TNFRSF9 TNF 24367709 2900933 Positive_regulation TNFRSF9 TNF 25096552 2252354 Positive_regulation TNFSF10 AHSA1 22462553 1230486 Positive_regulation TNFSF10 AKT1 20839416 806594 Positive_regulation TNFSF10 AKT1 22159760 2170481 Positive_regulation TNFSF10 AKT1 22159760 2170491 Positive_regulation TNFSF10 AKT1 25003395 504999 Positive_regulation TNFSF10 AKT1 PMC2834064 134545 Positive_regulation TNFSF10 AKT2 20839416 806595 Positive_regulation TNFSF10 AKT2 22159760 2170482 Positive_regulation TNFSF10 AKT2 22159760 2170492 Positive_regulation TNFSF10 AKT2 25003395 505000 Positive_regulation TNFSF10 AKT2 PMC2834064 134546 Positive_regulation TNFSF10 AKT3 20839416 806596 Positive_regulation TNFSF10 AKT3 22159760 2170483 Positive_regulation TNFSF10 AKT3 22159760 2170493 Positive_regulation TNFSF10 AKT3 25003395 505001 Positive_regulation TNFSF10 AKT3 PMC2834064 134547 Positive_regulation TNFSF10 ANXA5 19895686 254581 Positive_regulation TNFSF10 ASIP 23754197 1141764 Positive_regulation TNFSF10 BAX 17965760 810769 Positive_regulation TNFSF10 BCL10 22675673 940817 Positive_regulation TNFSF10 BCL2 22675673 940818 Positive_regulation TNFSF10 BCL3 22675673 940819 Positive_regulation TNFSF10 BCL5 22675673 940813 Positive_regulation TNFSF10 BCL6 22675673 940814 Positive_regulation TNFSF10 BCL9 22675673 940815 Positive_regulation TNFSF10 BIRC2 18606850 1353496 Positive_regulation TNFSF10 BIRC2 24633224 2934764 Positive_regulation TNFSF10 BIRC3 20062539 2436815 Positive_regulation TNFSF10 BTK 15007095 1531787 Positive_regulation TNFSF10 BUD13 16709253 3107265 Positive_regulation TNFSF10 BUD31 16709253 3107266 Positive_regulation TNFSF10 CA2 24732038 2952067 Positive_regulation TNFSF10 CASP1 19549337 1850990 Positive_regulation TNFSF10 CASP1 19549337 1850991 Positive_regulation TNFSF10 CASP1 21899742 1863308 Positive_regulation TNFSF10 CASP1 22438963 2612399 Positive_regulation TNFSF10 CASP1 25321472 578279 Positive_regulation TNFSF10 CASP10 19549337 1850992 Positive_regulation TNFSF10 CASP10 19549337 1850993 Positive_regulation TNFSF10 CASP10 21368896 551251 Positive_regulation TNFSF10 CASP10 21899742 1863309 Positive_regulation TNFSF10 CASP10 22438963 2612400 Positive_regulation TNFSF10 CASP10 25321472 578280 Positive_regulation TNFSF10 CASP12 19549337 1851012 Positive_regulation TNFSF10 CASP12 19549337 1851013 Positive_regulation TNFSF10 CASP12 21899742 1863319 Positive_regulation TNFSF10 CASP12 22438963 2612410 Positive_regulation TNFSF10 CASP12 22613960 1140847 Positive_regulation TNFSF10 CASP12 22613960 1140857 Positive_regulation TNFSF10 CASP12 25321472 578290 Positive_regulation TNFSF10 CASP14 19549337 1850994 Positive_regulation TNFSF10 CASP14 19549337 1850995 Positive_regulation TNFSF10 CASP14 21899742 1863310 Positive_regulation TNFSF10 CASP14 22438963 2612401 Positive_regulation TNFSF10 CASP14 25321472 578281 Positive_regulation TNFSF10 CASP16 19549337 1851014 Positive_regulation TNFSF10 CASP16 19549337 1851015 Positive_regulation TNFSF10 CASP16 21899742 1863320 Positive_regulation TNFSF10 CASP16 22438963 2612411 Positive_regulation TNFSF10 CASP16 25321472 578291 Positive_regulation TNFSF10 CASP2 19549337 1850996 Positive_regulation TNFSF10 CASP2 19549337 1850997 Positive_regulation TNFSF10 CASP2 20416058 1854445 Positive_regulation TNFSF10 CASP2 21899742 1863311 Positive_regulation TNFSF10 CASP2 22438963 2612402 Positive_regulation TNFSF10 CASP2 25321472 578282 Positive_regulation TNFSF10 CASP3 19421137 2125102 Positive_regulation TNFSF10 CASP3 19549337 1850998 Positive_regulation TNFSF10 CASP3 19549337 1850999 Positive_regulation TNFSF10 CASP3 20113484 1853227 Positive_regulation TNFSF10 CASP3 21899742 1863312 Positive_regulation TNFSF10 CASP3 22048166 553359 Positive_regulation TNFSF10 CASP3 22048166 553418 Positive_regulation TNFSF10 CASP3 22438963 2612403 Positive_regulation TNFSF10 CASP3 22613960 1140849 Positive_regulation TNFSF10 CASP3 23348588 559142 Positive_regulation TNFSF10 CASP3 23370279 559375 Positive_regulation TNFSF10 CASP3 23370279 559376 Positive_regulation TNFSF10 CASP3 23470485 2182448 Positive_regulation TNFSF10 CASP3 23703388 561927 Positive_regulation TNFSF10 CASP3 23703388 561932 Positive_regulation TNFSF10 CASP3 24603337 572758 Positive_regulation TNFSF10 CASP3 24910845 948144 Positive_regulation TNFSF10 CASP3 25321472 578283 Positive_regulation TNFSF10 CASP4 19549337 1851000 Positive_regulation TNFSF10 CASP4 19549337 1851001 Positive_regulation TNFSF10 CASP4 21899742 1863313 Positive_regulation TNFSF10 CASP4 22438963 2612404 Positive_regulation TNFSF10 CASP4 25321472 578284 Positive_regulation TNFSF10 CASP5 19549337 1851002 Positive_regulation TNFSF10 CASP5 19549337 1851003 Positive_regulation TNFSF10 CASP5 21899742 1863314 Positive_regulation TNFSF10 CASP5 22438963 2612405 Positive_regulation TNFSF10 CASP5 25321472 578285 Positive_regulation TNFSF10 CASP6 19549337 1851004 Positive_regulation TNFSF10 CASP6 19549337 1851005 Positive_regulation TNFSF10 CASP6 21899742 1863315 Positive_regulation TNFSF10 CASP6 22438963 2612406 Positive_regulation TNFSF10 CASP6 25321472 578286 Positive_regulation TNFSF10 CASP7 19549337 1851006 Positive_regulation TNFSF10 CASP7 19549337 1851007 Positive_regulation TNFSF10 CASP7 21899742 1863316 Positive_regulation TNFSF10 CASP7 22438963 2612407 Positive_regulation TNFSF10 CASP7 22613960 1140850 Positive_regulation TNFSF10 CASP7 24910845 948145 Positive_regulation TNFSF10 CASP7 25321472 578287 Positive_regulation TNFSF10 CASP8 12771998 422658 Positive_regulation TNFSF10 CASP8 17118156 384171 Positive_regulation TNFSF10 CASP8 19549337 1851008 Positive_regulation TNFSF10 CASP8 19549337 1851009 Positive_regulation TNFSF10 CASP8 20416058 1854451 Positive_regulation TNFSF10 CASP8 20646307 256698 Positive_regulation TNFSF10 CASP8 20646307 256715 Positive_regulation TNFSF10 CASP8 20661217 2133101 Positive_regulation TNFSF10 CASP8 20967281 2478629 Positive_regulation TNFSF10 CASP8 21858177 2546814 Positive_regulation TNFSF10 CASP8 21899742 1863317 Positive_regulation TNFSF10 CASP8 22110595 2572317 Positive_regulation TNFSF10 CASP8 22438963 2612408 Positive_regulation TNFSF10 CASP8 22619505 1136915 Positive_regulation TNFSF10 CASP8 23348585 559121 Positive_regulation TNFSF10 CASP8 23348588 559143 Positive_regulation TNFSF10 CASP8 23370279 559377 Positive_regulation TNFSF10 CASP8 23432760 267887 Positive_regulation TNFSF10 CASP8 23470485 2182449 Positive_regulation TNFSF10 CASP8 23703388 561933 Positive_regulation TNFSF10 CASP8 24034452 399402 Positive_regulation TNFSF10 CASP8 24603337 572759 Positive_regulation TNFSF10 CASP8 24690311 272529 Positive_regulation TNFSF10 CASP8 24745479 474625 Positive_regulation TNFSF10 CASP8 25321472 578288 Positive_regulation TNFSF10 CASP8 25321472 578345 Positive_regulation TNFSF10 CASP9 19549337 1851010 Positive_regulation TNFSF10 CASP9 19549337 1851011 Positive_regulation TNFSF10 CASP9 21899742 1863318 Positive_regulation TNFSF10 CASP9 22438963 2612409 Positive_regulation TNFSF10 CASP9 23091403 3129155 Positive_regulation TNFSF10 CASP9 23348585 559122 Positive_regulation TNFSF10 CASP9 24603337 572754 Positive_regulation TNFSF10 CASP9 25321472 578289 Positive_regulation TNFSF10 CASP9 25321472 578346 Positive_regulation TNFSF10 CD28 22412938 2609854 Positive_regulation TNFSF10 CD28 22412938 2609858 Positive_regulation TNFSF10 CD3D 10224285 1511699 Positive_regulation TNFSF10 CD3E 10224285 1511700 Positive_regulation TNFSF10 CD3G 10224285 1511701 Positive_regulation TNFSF10 CD40 24232092 569069 Positive_regulation TNFSF10 CD70 24481449 571789 Positive_regulation TNFSF10 CDH13 24244613 2880950 Positive_regulation TNFSF10 CFLAR 20062539 2436817 Positive_regulation TNFSF10 CFLAR 22348197 497093 Positive_regulation TNFSF10 CFLAR 22675673 940816 Positive_regulation TNFSF10 CFLAR 25379355 1243451 Positive_regulation TNFSF10 CNTN2 17907802 3039884 Positive_regulation TNFSF10 CPE 21779520 2115021 Positive_regulation TNFSF10 CSF1 23762095 637753 Positive_regulation TNFSF10 CSF2 10209050 1511640 Positive_regulation TNFSF10 CXCR4 19390584 1746577 Positive_regulation TNFSF10 CYCS 24603337 572755 Positive_regulation TNFSF10 CYCS 25149175 2198227 Positive_regulation TNFSF10 CYTIP 24887152 2975840 Positive_regulation TNFSF10 DDX58 22087337 2571549 Positive_regulation TNFSF10 DDX58 22087337 2571551 Positive_regulation TNFSF10 DDX58 24369016 185972 Positive_regulation TNFSF10 DIABLO 18590557 1848988 Positive_regulation TNFSF10 DISC1 23988408 2184712 Positive_regulation TNFSF10 DISC2 23988408 2184713 Positive_regulation TNFSF10 EGFR 23840967 1154152 Positive_regulation TNFSF10 EIF2AK2 23468627 3060376 Positive_regulation TNFSF10 EPHB2 20839416 806593 Positive_regulation TNFSF10 FADD 21264287 2495208 Positive_regulation TNFSF10 FAS 19654878 2422799 Positive_regulation TNFSF10 FAS 20967287 2370821 Positive_regulation TNFSF10 FAS 22084408 1566079 Positive_regulation TNFSF10 FAS 23191987 357291 Positive_regulation TNFSF10 FAS 24130482 3064386 Positive_regulation TNFSF10 FAS 24130482 3064389 Positive_regulation TNFSF10 FAS 25197653 198812 Positive_regulation TNFSF10 FASLG 22084408 1566081 Positive_regulation TNFSF10 FASLG 22087287 2571280 Positive_regulation TNFSF10 FASLG 23429285 559991 Positive_regulation TNFSF10 FASN 23348588 559144 Positive_regulation TNFSF10 FOXO3 21179458 2488068 Positive_regulation TNFSF10 FOXO3 21179458 2488069 Positive_regulation TNFSF10 FOXO3 22159760 2170480 Positive_regulation TNFSF10 FOXO3 22159760 2170503 Positive_regulation TNFSF10 FOXO3 22892844 478735 Positive_regulation TNFSF10 FOXO3 22892844 478750 Positive_regulation TNFSF10 FOXO3 23828551 2183551 Positive_regulation TNFSF10 GABPA 25009785 3094594 Positive_regulation TNFSF10 GP2 23807159 2171417 Positive_regulation TNFSF10 GP5 23807159 2171418 Positive_regulation TNFSF10 GP6 23807159 2171416 Positive_regulation TNFSF10 GP9 23807159 2171419 Positive_regulation TNFSF10 GRAP2 23514593 3121435 Positive_regulation TNFSF10 GSN 22952982 2685603 Positive_regulation TNFSF10 HDAC1 21603612 2523483 Positive_regulation TNFSF10 HDAC2 20398369 1853927 Positive_regulation TNFSF10 HDAC2 21603612 2523484 Positive_regulation TNFSF10 HLA-DRB1 19352384 432056 Positive_regulation TNFSF10 HLA-DRB1 20087343 434320 Positive_regulation TNFSF10 HLA-DRB1 20419158 3046609 Positive_regulation TNFSF10 HLA-DRB1 20661477 2456843 Positive_regulation TNFSF10 HLA-DRB1 21209944 2492505 Positive_regulation TNFSF10 HLA-DRB1 22213832 1882541 Positive_regulation TNFSF10 HLA-DRB1 22681760 264867 Positive_regulation TNFSF10 HLA-DRB1 23191987 357292 Positive_regulation TNFSF10 HRAS 24216995 500845 Positive_regulation TNFSF10 ICAM1 21562052 1637157 Positive_regulation TNFSF10 ICAM1 22048166 553292 Positive_regulation TNFSF10 ICAM1 22048166 553293 Positive_regulation TNFSF10 ICAM1 22048166 553294 Positive_regulation TNFSF10 IFI27 24970806 2193915 Positive_regulation TNFSF10 IFI27 24970806 2193916 Positive_regulation TNFSF10 IFI27 24970806 2193920 Positive_regulation TNFSF10 IFI35 24978043 2985495 Positive_regulation TNFSF10 IFN1@ 22084408 1566082 Positive_regulation TNFSF10 IFN1@ 23242206 141594 Positive_regulation TNFSF10 IFN1@ 24455433 3151131 Positive_regulation TNFSF10 IFN1@ 24455433 3151146 Positive_regulation TNFSF10 IFN1@ 25122141 3069015 Positive_regulation TNFSF10 IFNAR1 23468627 3060373 Positive_regulation TNFSF10 IFNAR1 23468627 3060375 Positive_regulation TNFSF10 IFNAR1 25505958 652097 Positive_regulation TNFSF10 IFNG 24978043 2985496 Positive_regulation TNFSF10 IGF1 23091403 3129179 Positive_regulation TNFSF10 IL10 10209050 1511641 Positive_regulation TNFSF10 IL12A 11257133 1519053 Positive_regulation TNFSF10 IL12A 11257133 1519054 Positive_regulation TNFSF10 IL12A 11257133 1519067 Positive_regulation TNFSF10 IL12A 11257133 1519071 Positive_regulation TNFSF10 IL12A 11257133 1519073 Positive_regulation TNFSF10 IL12A 24367714 2372342 Positive_regulation TNFSF10 IL12A 25356750 3020643 Positive_regulation TNFSF10 IL12B 11257133 1519055 Positive_regulation TNFSF10 IL12B 11257133 1519056 Positive_regulation TNFSF10 IL12B 11257133 1519068 Positive_regulation TNFSF10 IL12B 11257133 1519072 Positive_regulation TNFSF10 IL12B 11257133 1519074 Positive_regulation TNFSF10 IL12B 24367714 2372343 Positive_regulation TNFSF10 IL12B 25356750 3020644 Positive_regulation TNFSF10 IL15 10209050 1511642 Positive_regulation TNFSF10 IL17D 24155891 2871143 Positive_regulation TNFSF10 IL17D 24155891 2871144 Positive_regulation TNFSF10 IL17D 24155891 2871145 Positive_regulation TNFSF10 IL17D 24155891 2871146 Positive_regulation TNFSF10 IL17D 24155891 2871160 Positive_regulation TNFSF10 IL17D 24155891 2871161 Positive_regulation TNFSF10 IL17D 24155891 2871162 Positive_regulation TNFSF10 IL17D 24155891 2871178 Positive_regulation TNFSF10 IL17D 24155891 2871182 Positive_regulation TNFSF10 IL18 11257133 1519065 Positive_regulation TNFSF10 IL18 25356750 3020645 Positive_regulation TNFSF10 IL18 PMC2833857 134380 Positive_regulation TNFSF10 IL1A 10209050 1511643 Positive_regulation TNFSF10 IL1A 20661477 2456883 Positive_regulation TNFSF10 IL1A 20661477 2456887 Positive_regulation TNFSF10 IL1A 22654557 678422 Positive_regulation TNFSF10 IL1A 23029025 2694259 Positive_regulation TNFSF10 IL1A PMC2833857 134389 Positive_regulation TNFSF10 IL3 10209050 1511644 Positive_regulation TNFSF10 IL3 24367714 2372344 Positive_regulation TNFSF10 IL6 10209050 1511645 Positive_regulation TNFSF10 IL8 17353365 1544789 Positive_regulation TNFSF10 IL8 21562052 1637158 Positive_regulation TNFSF10 IRF1 19404407 2415736 Positive_regulation TNFSF10 IRF1 19404407 2415755 Positive_regulation TNFSF10 IRF1 19404407 2415768 Positive_regulation TNFSF10 IRF1 19404407 2415769 Positive_regulation TNFSF10 IRF3 21829705 2542478 Positive_regulation TNFSF10 IRF3 21829705 2542482 Positive_regulation TNFSF10 IRF3 21829705 2542483 Positive_regulation TNFSF10 IRF3 24369016 185967 Positive_regulation TNFSF10 IRF7 19404407 2415770 Positive_regulation TNFSF10 IRF7 24369016 185968 Positive_regulation TNFSF10 ITIH4 22110611 2572640 Positive_regulation TNFSF10 KRR1 23096115 557873 Positive_regulation TNFSF10 MADD 21915099 770793 Positive_regulation TNFSF10 MAP3K7 20062539 2436808 Positive_regulation TNFSF10 MAPK1 23514593 3121436 Positive_regulation TNFSF10 MAPK10 23514593 3121437 Positive_regulation TNFSF10 MAPK11 23514593 3121438 Positive_regulation TNFSF10 MAPK12 23514593 3121439 Positive_regulation TNFSF10 MAPK13 23514593 3121440 Positive_regulation TNFSF10 MAPK14 23514593 3121441 Positive_regulation TNFSF10 MAPK15 23514593 3121434 Positive_regulation TNFSF10 MAPK3 20204172 1747115 Positive_regulation TNFSF10 MAPK3 20204172 1747123 Positive_regulation TNFSF10 MAPK3 22279582 2590808 Positive_regulation TNFSF10 MAPK3 23514593 3121442 Positive_regulation TNFSF10 MAPK3 PMC2834064 134548 Positive_regulation TNFSF10 MAPK4 23514593 3121443 Positive_regulation TNFSF10 MAPK6 23514593 3121444 Positive_regulation TNFSF10 MAPK7 23514593 3121445 Positive_regulation TNFSF10 MAPK8 21654829 552326 Positive_regulation TNFSF10 MAPK8 22279582 2590809 Positive_regulation TNFSF10 MAPK8 23514593 3121446 Positive_regulation TNFSF10 MAPK9 21654829 552327 Positive_regulation TNFSF10 MAPK9 23514593 3121447 Positive_regulation TNFSF10 MAVS 24369016 185973 Positive_regulation TNFSF10 MCL1 24529193 271603 Positive_regulation TNFSF10 MCL1 24529193 271620 Positive_regulation TNFSF10 MET 24748276 2956033 Positive_regulation TNFSF10 MET 24748276 2956061 Positive_regulation TNFSF10 MYLIP 22303357 881742 Positive_regulation TNFSF10 MYLIP 24905916 2977435 Positive_regulation TNFSF10 NAALADL1 20706677 979133 Positive_regulation TNFSF10 NFATC1 21603612 2523445 Positive_regulation TNFSF10 NFATC1 21603612 2523454 Positive_regulation TNFSF10 NFATC1 21603612 2523461 Positive_regulation TNFSF10 NFATC1 21603612 2523462 Positive_regulation TNFSF10 NFATC1 21603612 2523466 Positive_regulation TNFSF10 NFATC1 21603612 2523475 Positive_regulation TNFSF10 NFATC1 21603612 2523476 Positive_regulation TNFSF10 NFATC1 21603612 2523477 Positive_regulation TNFSF10 NFATC1 21603612 2523485 Positive_regulation TNFSF10 NFATC1 21603612 2523503 Positive_regulation TNFSF10 NFATC1 21603612 2523509 Positive_regulation TNFSF10 NFATC1 22696685 1804019 Positive_regulation TNFSF10 NFATC1 22719861 2653300 Positive_regulation TNFSF10 NFATC1 22719861 2653301 Positive_regulation TNFSF10 NFATC2 21603612 2523504 Positive_regulation TNFSF10 NFATC2IP 23170112 842636 Positive_regulation TNFSF10 NFATC3 21603612 2523455 Positive_regulation TNFSF10 NFATC4 21603612 2523456 Positive_regulation TNFSF10 PARP1 20113484 1853235 Positive_regulation TNFSF10 PARP10 20113484 1853230 Positive_regulation TNFSF10 PARP11 20113484 1853226 Positive_regulation TNFSF10 PARP12 20113484 1853228 Positive_regulation TNFSF10 PARP14 20113484 1853239 Positive_regulation TNFSF10 PARP15 20113484 1853233 Positive_regulation TNFSF10 PARP16 20113484 1853231 Positive_regulation TNFSF10 PARP2 20113484 1853237 Positive_regulation TNFSF10 PARP3 20113484 1853238 Positive_regulation TNFSF10 PARP4 20113484 1853236 Positive_regulation TNFSF10 PARP6 20113484 1853234 Positive_regulation TNFSF10 PARP8 20113484 1853232 Positive_regulation TNFSF10 PARP9 20113484 1853229 Positive_regulation TNFSF10 PDCD1 15833141 3104984 Positive_regulation TNFSF10 PDCD1 23937794 269654 Positive_regulation TNFSF10 PDCD1 24402744 492190 Positive_regulation TNFSF10 PDCD10 15833141 3104985 Positive_regulation TNFSF10 PDCD10 23937794 269655 Positive_regulation TNFSF10 PDCD10 24402744 492191 Positive_regulation TNFSF10 PDCD11 15833141 3104983 Positive_regulation TNFSF10 PDCD11 23937794 269653 Positive_regulation TNFSF10 PDCD11 24402744 492189 Positive_regulation TNFSF10 PDCD2 15833141 3104986 Positive_regulation TNFSF10 PDCD2 23937794 269656 Positive_regulation TNFSF10 PDCD2 24402744 492192 Positive_regulation TNFSF10 PDCD4 15833141 3104987 Positive_regulation TNFSF10 PDCD4 23937794 269657 Positive_regulation TNFSF10 PDCD4 24402744 492193 Positive_regulation TNFSF10 PDCD5 15833141 3104988 Positive_regulation TNFSF10 PDCD5 23937794 269658 Positive_regulation TNFSF10 PDCD5 24402744 492194 Positive_regulation TNFSF10 PDCD6 15833141 3104989 Positive_regulation TNFSF10 PDCD6 23937794 269659 Positive_regulation TNFSF10 PDCD6 24402744 492195 Positive_regulation TNFSF10 PDCD7 15833141 3104990 Positive_regulation TNFSF10 PDCD7 23937794 269660 Positive_regulation TNFSF10 PDCD7 24402744 492196 Positive_regulation TNFSF10 PGP 20663232 1857137 Positive_regulation TNFSF10 PIK3CA 25003395 505002 Positive_regulation TNFSF10 PIK3R1 25003395 505003 Positive_regulation TNFSF10 PTGS2 PMC4212306 3206578 Positive_regulation TNFSF10 RBBP4 21603612 2523486 Positive_regulation TNFSF10 RBBP7 21603612 2523487 Positive_regulation TNFSF10 RELA 19895686 254584 Positive_regulation TNFSF10 RIPK3 24507727 271494 Positive_regulation TNFSF10 SELE 21562052 1637156 Positive_regulation TNFSF10 SERPINF1 22892844 478732 Positive_regulation TNFSF10 SMCP 21092273 1860252 Positive_regulation TNFSF10 SP1 21603612 2523444 Positive_regulation TNFSF10 SP1 21603612 2523482 Positive_regulation TNFSF10 SP1 22892844 478748 Positive_regulation TNFSF10 STAT1 19404407 2415729 Positive_regulation TNFSF10 STAT1 19404407 2415735 Positive_regulation TNFSF10 STAT1 19404407 2415754 Positive_regulation TNFSF10 STAT1 19404407 2415767 Positive_regulation TNFSF10 STAT1 23087808 1028189 Positive_regulation TNFSF10 STAT1 25505958 652094 Positive_regulation TNFSF10 STAT3 23514593 3121433 Positive_regulation TNFSF10 STAT3 25505958 652095 Positive_regulation TNFSF10 STK11 19347029 2125006 Positive_regulation TNFSF10 STK11 25244018 1130724 Positive_regulation TNFSF10 TANK 18606850 1353495 Positive_regulation TNFSF10 TAT 18769477 2395885 Positive_regulation TNFSF10 TAT 20862322 3048574 Positive_regulation TNFSF10 TAT 21368875 550917 Positive_regulation TNFSF10 TLR1 19686596 3118104 Positive_regulation TNFSF10 TLR1 24762633 504500 Positive_regulation TNFSF10 TLR1 25196285 3224133 Positive_regulation TNFSF10 TLR10 19686596 3118112 Positive_regulation TNFSF10 TLR10 24762633 504508 Positive_regulation TNFSF10 TLR10 25196285 3224141 Positive_regulation TNFSF10 TLR2 19686596 3118105 Positive_regulation TNFSF10 TLR2 24762633 504501 Positive_regulation TNFSF10 TLR2 25196285 3224134 Positive_regulation TNFSF10 TLR3 19686596 3118106 Positive_regulation TNFSF10 TLR3 22892844 478749 Positive_regulation TNFSF10 TLR3 23370279 559373 Positive_regulation TNFSF10 TLR3 23370279 559374 Positive_regulation TNFSF10 TLR3 23370279 559383 Positive_regulation TNFSF10 TLR3 24762633 504502 Positive_regulation TNFSF10 TLR3 25196285 3224135 Positive_regulation TNFSF10 TLR4 19686596 3118107 Positive_regulation TNFSF10 TLR4 24762633 504503 Positive_regulation TNFSF10 TLR4 25196285 3224136 Positive_regulation TNFSF10 TLR5 19686596 3118108 Positive_regulation TNFSF10 TLR5 24762633 504504 Positive_regulation TNFSF10 TLR5 25196285 3224137 Positive_regulation TNFSF10 TLR6 19686596 3118113 Positive_regulation TNFSF10 TLR6 24762633 504509 Positive_regulation TNFSF10 TLR6 25196285 3224142 Positive_regulation TNFSF10 TLR7 19686596 3118109 Positive_regulation TNFSF10 TLR7 24762633 504505 Positive_regulation TNFSF10 TLR7 25196285 3224138 Positive_regulation TNFSF10 TLR8 19686596 3118110 Positive_regulation TNFSF10 TLR8 24762633 504506 Positive_regulation TNFSF10 TLR8 25196285 3224139 Positive_regulation TNFSF10 TLR9 19686596 3118111 Positive_regulation TNFSF10 TLR9 24762633 504507 Positive_regulation TNFSF10 TLR9 25196285 3224140 Positive_regulation TNFSF10 TNF 21850048 552441 Positive_regulation TNFSF10 TNF 22654557 678421 Positive_regulation TNFSF10 TNF 23029025 2694278 Positive_regulation TNFSF10 TNF 24843320 1085241 Positive_regulation TNFSF10 TNF PMC2833857 134388 Positive_regulation TNFSF10 TNFRSF10A 15007095 1531788 Positive_regulation TNFSF10 TNFRSF10A 18504532 1644043 Positive_regulation TNFSF10 TNFRSF10A 20359743 2252726 Positive_regulation TNFSF10 TNFRSF10A 21625476 2524194 Positive_regulation TNFSF10 TNFRSF10A 22723798 901961 Positive_regulation TNFSF10 TNFRSF10B 10224285 1511703 Positive_regulation TNFSF10 TNFRSF10B 19247452 2406523 Positive_regulation TNFSF10 TNFRSF10B 20359743 2252727 Positive_regulation TNFSF10 TNFRSF10B 21625476 2524195 Positive_regulation TNFSF10 TNFRSF10B 22084408 1566078 Positive_regulation TNFSF10 TNFRSF10B 22723798 901962 Positive_regulation TNFSF10 TNFRSF10B 25358794 3167502 Positive_regulation TNFSF10 TNFRSF10B 25505958 652096 Positive_regulation TNFSF10 TNFRSF11B 22432033 2611721 Positive_regulation TNFSF10 TNFRSF6B 24204567 2873072 Positive_regulation TNFSF10 TNFSF10 15651986 248641 Positive_regulation TNFSF10 TNFSF10 22084408 1566080 Positive_regulation TNFSF10 TNFSF10 24086526 2854482 Positive_regulation TNFSF10 TNFSF10 24453421 1756804 Positive_regulation TNFSF10 TNFSF11 23300516 2733563 Positive_regulation TNFSF10 TNFSF11 23300516 2733590 Positive_regulation TNFSF10 TNFSF11 23762095 637752 Positive_regulation TNFSF10 TNFSF12 22438963 2612394 Positive_regulation TNFSF10 TNFSF12 22438963 2612412 Positive_regulation TNFSF10 TNFSF12 24130833 2867288 Positive_regulation TNFSF10 TP53 21824395 3112499 Positive_regulation TNFSF10 TP53 22892844 478734 Positive_regulation TNFSF10 TP53 22892844 478740 Positive_regulation TNFSF10 TP53 23594441 536006 Positive_regulation TNFSF10 TP63 24367714 2372341 Positive_regulation TNFSF10 TRAF6 22719861 2653281 Positive_regulation TNFSF10 TRAF6 22719861 2653282 Positive_regulation TNFSF10 TRAF6 22719861 2653283 Positive_regulation TNFSF10 TRAF6 22719861 2653299 Positive_regulation TNFSF10 TRAF6 22719861 2653338 Positive_regulation TNFSF10 TRD 19077262 1503468 Positive_regulation TNFSF10 TUB 24434509 570860 Positive_regulation TNFSF10 VDAC1 20646307 256687 Positive_regulation TNFSF10 VDAC1 20646307 256714 Positive_regulation TNFSF10 XBP1 22613960 1140863 Positive_regulation TNFSF11 EPHB2 16987426 106651 Positive_regulation TNFSF11 EPHB2 23396374 16936 Positive_regulation TNFSF11 EPHB2 23509596 817534 Positive_regulation TNFSF11 IL1B 18578867 110970 Positive_regulation TNFSF11 IL1B 21708014 123051 Positive_regulation TNFSF11 MMP7 24665208 487645 Positive_regulation TNFSF11 MMP7 24978435 504734 Positive_regulation TNFSF11 MMP7 24978435 504741 Positive_regulation TNFSF11 PGC 25367151 133801 Positive_regulation TNFSF11 PLAU 20010942 434237 Positive_regulation TNFSF11 TLR7 23295061 1725198 Positive_regulation TNFSF11 TNF 11805147 1522491 Positive_regulation TNFSF11 TNF 16669999 3107220 Positive_regulation TNFSF11 TNF 17963332 3231330 Positive_regulation TNFSF11 TNF 17963332 3231367 Positive_regulation TNFSF11 TNF 19686583 116590 Positive_regulation TNFSF11 TNF 19922639 117870 Positive_regulation TNFSF11 TNF 21294864 121415 Positive_regulation TNFSF11 TNF 21464945 2510677 Positive_regulation TNFSF11 TNF 21708014 123044 Positive_regulation TNFSF11 TNF 21861862 123875 Positive_regulation TNFSF11 TNF 22157665 1734717 Positive_regulation TNFSF11 TNF 22176920 3112883 Positive_regulation TNFSF11 TNF 22901757 126643 Positive_regulation TNFSF11 TNF 22901757 126644 Positive_regulation TNFSF11 TNF 22901757 126646 Positive_regulation TNFSF11 TNF 22901757 126648 Positive_regulation TNFSF11 TNF 23043770 126981 Positive_regulation TNFSF11 TNF 23406906 127951 Positive_regulation TNFSF11 TNF 23406906 127956 Positive_regulation TNFSF11 TNF 23762085 637575 Positive_regulation TNFSF11 TNF 23762085 637600 Positive_regulation TNFSF11 TNF 24019592 3079928 Positive_regulation TNFSF11 TNF 24457902 2186912 Positive_regulation TNFSF11 TNF 24719884 188824 Positive_regulation TNFSF11 TNF 24719884 188830 Positive_regulation TNFSF11 TNF 24744505 1758199 Positive_regulation TNFSF11 TNF 24837833 1126805 Positive_regulation TNFSF11 TNF 25110981 2996134 Positive_regulation TNFSF11 TNF PMC2833857 134390 Positive_regulation TNFSF11 TNF PMC4033988 2245992 Positive_regulation TNFSF11 TNFSF10 24040204 2846135 Positive_regulation TNFSF11 TNFSF10 24040204 2846140 Positive_regulation TNFSF11 ZFP57 23569325 1571154 Positive_regulation TNFSF11 ZFP57 23569325 1571248 Positive_regulation TNFSF11 ZFP57 23569325 1571435 Positive_regulation TNFSF12 FBXO32 22082477 682572 Positive_regulation TNFSF12 FBXO32 22082477 682573 Positive_regulation TNFSF12 FBXO32 22082477 682574 Positive_regulation TNFSF12 TNF 20967264 2478596 Positive_regulation TNFSF12 TNF 22394384 1661280 Positive_regulation TNFSF12 TNF 23469193 2763146 Positive_regulation TNFSF12 TNFSF10 22438963 2612395 Positive_regulation TNFSF13 MMP28 23383143 2748258 Positive_regulation TNFSF13 MMP7 23383143 2748273 Positive_regulation TNFSF13 TLR7 20803699 1050197 Positive_regulation TNFSF13B EPHB2 16301744 1538469 Positive_regulation TNFSF13B EPHB2 23620746 2783272 Positive_regulation TNFSF13B TLR7 17664289 1546748 Positive_regulation TNFSF13B TLR7 19291304 112956 Positive_regulation TNFSF13B TLR7 21818370 2540748 Positive_regulation TNFSF13B TLR7 21818370 2540749 Positive_regulation TNFSF13B TLR7 21818370 2540753 Positive_regulation TNFSF13B TLR7 23049531 904444 Positive_regulation TNFSF13B TLR7 23940791 2832483 Positive_regulation TNFSF13B TLR7 24877127 192046 Positive_regulation TNFSF13B TLR7 25076492 2993378 Positive_regulation TNFSF13B TLR7 25076492 2993379 Positive_regulation TNFSF13B TNF 16507175 105068 Positive_regulation TNFSF13B TNF 19291304 112946 Positive_regulation TNFSF13B TNF 20942964 362781 Positive_regulation TNFSF13B TNF 23264777 905504 Positive_regulation TNFSF15 ADAMTS1 23859810 694899 Positive_regulation TNFSF15 TLR7 20980995 1918012 Positive_regulation TNFSF15 TLR7 24453414 1756701 Positive_regulation TNFSF15 TLR7 24876829 681761 Positive_regulation TNFSF15 TNF 20980995 1918011 Positive_regulation TNFSF15 TNF 24416448 2909134 Positive_regulation TNFSF15 TNF 24416448 2909135 Positive_regulation TNFSF15 TNF 24416448 2909152 Positive_regulation TNFSF15 TNF 24416448 2909156 Positive_regulation TNFSF15 TNF 25148371 3001980 Positive_regulation TNFSF15 TNF 25330517 3205492 Positive_regulation TNFSF4 TNF 24224471 641139 Positive_regulation TNFSF4 TNF PMC4288337 1623777 Positive_regulation TNIP1 TNF 22654485 1224271 Positive_regulation TNIP1 TNF 24688608 2208335 Positive_regulation TNKS2 AXIN2 22473005 610591 Positive_regulation TNMD EPHB2 23157718 3207785 Positive_regulation TNMD TNF 20308428 1373821 Positive_regulation TNNI2 MYOG 21798092 3160251 Positive_regulation TNNI3K EPHB2 23472207 2764553 Positive_regulation TNNI3K EPHB2 23472207 2764563 Positive_regulation TNNT1 FAS 22514537 957095 Positive_regulation TNNT2 ARRB2 24974728 1483590 Positive_regulation TNNT2 GATA4 19396158 1983365 Positive_regulation TNNT2 HAND1 25050861 2991093 Positive_regulation TNNT2 MAGEE1 24204736 2874214 Positive_regulation TNNT2 NKX2-5 25050861 2991092 Positive_regulation TNNT2 NOTCH1 25050861 2991094 Positive_regulation TNNT2 SMARCD3 19396158 1983363 Positive_regulation TNNT2 TBX5 19396158 1983364 Positive_regulation TNP1 RCAN1 19124655 1553481 Positive_regulation TNP2 RCAN1 19124655 1553482 Positive_regulation TNPO1 EPHB2 25166426 3003720 Positive_regulation TNPO1 MIP 24058610 2848251 Positive_regulation TNPO1 TNF 11877479 1523098 Positive_regulation TNPO1 TNF 19152704 659106 Positive_regulation TNPO1 TNF 19686583 116599 Positive_regulation TNPO1 TNF 19901996 1746784 Positive_regulation TNPO1 TNF 19901996 1746786 Positive_regulation TNPO1 TNF 21857970 2544486 Positive_regulation TNPO1 TNF 23234294 1665477 Positive_regulation TNR TNF 19712456 1696373 Positive_regulation TNS1 BCL10 25009550 970903 Positive_regulation TNS1 CRK 18776587 736218 Positive_regulation TNS1 HTRA2 25206509 2004909 Positive_regulation TNS1 HTRA2 25206509 2004923 Positive_regulation TNS1 LRRK2 25206509 2004910 Positive_regulation TNS1 LRRK2 25206509 2004924 Positive_regulation TNS1 MALT1 25009550 970902 Positive_regulation TNS1 NR4A2 25206509 2004911 Positive_regulation TNS1 PGC 20517466 137590 Positive_regulation TNS1 PINK1 20517466 137588 Positive_regulation TNS1 PINK1 25302295 200832 Positive_regulation TNS1 PTEN 24222802 2214812 Positive_regulation TNS1 SIRT1 20517466 137589 Positive_regulation TNS1 TAB2 25009550 970901 Positive_regulation TNS1 TLN1 7593197 1437690 Positive_regulation TNS1 TLN2 7593197 1437692 Positive_regulation TNS1 TRAF6 25009550 970899 Positive_regulation TNS1 UBE2V1 25009550 970900 Positive_regulation TNS1 VCL 7593197 1437691 Positive_regulation TOC MIP 24958291 1764811 Positive_regulation TOP1 FAS 22066019 2568840 Positive_regulation TP53 AXIN2 20122174 1853319 Positive_regulation TP53 AXIN2 22889244 1506459 Positive_regulation TP53 AXIN2 23826318 2811932 Positive_regulation TP53 AXIN2 23826318 2811939 Positive_regulation TP53 AXIN2 23826318 2811941 Positive_regulation TP53 CCND1 11161387 418287 Positive_regulation TP53 CCND1 22548705 1865874 Positive_regulation TP53 CCND1 22548705 1865875 Positive_regulation TP53 CCND1 22548705 1865882 Positive_regulation TP53 CCND1 23390492 2750689 Positive_regulation TP53 CCND1 23390492 2750690 Positive_regulation TP53 CCND1 23555779 2775293 Positive_regulation TP53 CCND1 23776583 2804814 Positive_regulation TP53 CDKN1C 22778557 1224568 Positive_regulation TP53 CLU 24223536 867750 Positive_regulation TP53 CTGF 22438586 1801403 Positive_regulation TP53 CTGF 22438586 1801404 Positive_regulation TP53 CTGF 22438586 1801405 Positive_regulation TP53 CTGF 22438586 1801413 Positive_regulation TP53 CTGF 22438586 1801415 Positive_regulation TP53 DAPK1 20145727 1065988 Positive_regulation TP53 DAPK1 24710481 618666 Positive_regulation TP53 EPHB2 18847491 251678 Positive_regulation TP53 EPHB2 20190820 2129154 Positive_regulation TP53 EPHB2 20727231 466211 Positive_regulation TP53 EPHB2 22087839 681975 Positive_regulation TP53 EPHB2 22087839 681987 Positive_regulation TP53 EPHB2 22087839 682011 Positive_regulation TP53 EPHB2 23342042 2741740 Positive_regulation TP53 EPHB2 23434831 1729669 Positive_regulation TP53 EPHB2 23844043 2819129 Positive_regulation TP53 EPHB2 23844043 2819130 Positive_regulation TP53 EPHB2 24250280 2299027 Positive_regulation TP53 EPHB2 25068118 3167127 Positive_regulation TP53 EPHB2 25162007 197910 Positive_regulation TP53 EPHB2 25162007 197929 Positive_regulation TP53 FAS 15038834 382345 Positive_regulation TP53 FAS 21364648 549817 Positive_regulation TP53 FAS 23166734 2718820 Positive_regulation TP53 FAS 23166734 2718828 Positive_regulation TP53 FAS 25337543 1241227 Positive_regulation TP53 FAS 9841917 1604746 Positive_regulation TP53 FAS 9841917 1604750 Positive_regulation TP53 FOXO1 20157574 26592 Positive_regulation TP53 HBEGF 23236372 2725995 Positive_regulation TP53 HBEGF 23236372 2726018 Positive_regulation TP53 HBEGF 23236372 2726023 Positive_regulation TP53 JAG1 24098521 2858040 Positive_regulation TP53 JAG1 24098521 2858060 Positive_regulation TP53 LGALS7B 23530091 2182807 Positive_regulation TP53 LGALS7B 23530091 2182808 Positive_regulation TP53 LGALS7B 23967302 2835648 Positive_regulation TP53 LGALS7B 23967302 2835649 Positive_regulation TP53 LGALS7B 23967302 2835650 Positive_regulation TP53 LGALS7B 23967302 2835651 Positive_regulation TP53 LGALS7B 23967302 2835658 Positive_regulation TP53 LGALS7B 23967302 2835660 Positive_regulation TP53 LGALS7B 23967302 2835666 Positive_regulation TP53 LGALS7B 25277199 2203316 Positive_regulation TP53 LGALS7B 25277199 2203320 Positive_regulation TP53 LGALS7B 25277199 2203323 Positive_regulation TP53 LHX4 24157876 568516 Positive_regulation TP53 MAP2K6 20190820 2129160 Positive_regulation TP53 MAP2K6 23638878 1868017 Positive_regulation TP53 MAP2K6 23638878 1868100 Positive_regulation TP53 MAP2K6 23638878 1868145 Positive_regulation TP53 NES 19445705 734028 Positive_regulation TP53 NES 20967502 849201 Positive_regulation TP53 NES 21092204 734113 Positive_regulation TP53 NES 23825024 1816860 Positive_regulation TP53 NES 23825024 1816869 Positive_regulation TP53 NGFR 17540029 320269 Positive_regulation TP53 OSR1 24931004 1681256 Positive_regulation TP53 OSR1 24931004 1681289 Positive_regulation TP53 PGC 23764844 562310 Positive_regulation TP53 PLAU 23864708 1816990 Positive_regulation TP53 PLAU 23864708 1817017 Positive_regulation TP53 PRODH 17612399 233048 Positive_regulation TP53 S100A7 25621169 1727228 Positive_regulation TP53 TLR7 21483755 2323120 Positive_regulation TP53 TNF 17567906 370616 Positive_regulation TP53 TNF 18213398 804414 Positive_regulation TP53 TNF 20406462 1853950 Positive_regulation TP53 TNF 22719951 2653891 Positive_regulation TP53 TNF 22911714 2675951 Positive_regulation TP53 TNF 22911714 2675957 Positive_regulation TP53 TNF 22911714 2675958 Positive_regulation TP53 TNF 24198657 1614415 Positive_regulation TP53 TNF 24634836 3094365 Positive_regulation TP53 TNF 25258680 1675228 Positive_regulation TP53 TNF 8914651 1030861 Positive_regulation TP53 TP63 11336476 418727 Positive_regulation TP53 TP63 18660513 2035451 Positive_regulation TP53 TP63 18676979 2035565 Positive_regulation TP53 TP63 22389628 2278518 Positive_regulation TP53 TP63 23420876 1570857 Positive_regulation TP53 TP63 24709709 617191 Positive_regulation TP53 WIF1 24853424 576261 Positive_regulation TP53 WIF1 24853424 576267 Positive_regulation TP53 WIF1 24853424 576269 Positive_regulation TP53BP2 TP63 18676979 2035569 Positive_regulation TP53INP1 TNF 19356238 113107 Positive_regulation TP53INP1 TNF 19356238 113108 Positive_regulation TP63 AKT1 19517019 2419062 Positive_regulation TP63 AKT1 23545251 2182976 Positive_regulation TP63 AKT2 19517019 2419063 Positive_regulation TP63 AKT2 23545251 2182977 Positive_regulation TP63 AKT3 19517019 2419064 Positive_regulation TP63 AKT3 23545251 2182978 Positive_regulation TP63 ANXA6 23149662 1919545 Positive_regulation TP63 APC 23509806 180544 Positive_regulation TP63 CA2 22622428 1630947 Positive_regulation TP63 CASP1 24822180 190505 Positive_regulation TP63 CASP10 24822180 190506 Positive_regulation TP63 CASP12 24822180 190516 Positive_regulation TP63 CASP14 24822180 190507 Positive_regulation TP63 CASP16 24822180 190517 Positive_regulation TP63 CASP2 24822180 190508 Positive_regulation TP63 CASP3 20429941 328922 Positive_regulation TP63 CASP3 24822180 190509 Positive_regulation TP63 CASP4 24822180 190510 Positive_regulation TP63 CASP5 24822180 190511 Positive_regulation TP63 CASP6 24822180 190512 Positive_regulation TP63 CASP7 24822180 190513 Positive_regulation TP63 CASP8 20429941 328923 Positive_regulation TP63 CASP8 24822180 190514 Positive_regulation TP63 CASP9 24822180 190515 Positive_regulation TP63 CD40LG 12223112 99366 Positive_regulation TP63 CD40LG 23837669 128442 Positive_regulation TP63 CDK9 19091128 3117563 Positive_regulation TP63 CKAP4 24621512 2933494 Positive_regulation TP63 CLEC7A 24350246 185816 Positive_regulation TP63 CNR2 20634917 2243956 Positive_regulation TP63 CNTRL 18627611 323777 Positive_regulation TP63 CSF2 10811870 1515476 Positive_regulation TP63 ETS2 19047440 1552999 Positive_regulation TP63 FASN 19517019 2419061 Positive_regulation TP63 FGF10 25329657 2366344 Positive_regulation TP63 FGF7 25329657 2366345 Positive_regulation TP63 GRAP2 23334153 3217657 Positive_regulation TP63 HBEGF 25186587 1768393 Positive_regulation TP63 HGF 24917821 965242 Positive_regulation TP63 HNRNPF 16818672 1541000 Positive_regulation TP63 HNRNPF 17254326 1620425 Positive_regulation TP63 HNRNPF 25552899 743686 Positive_regulation TP63 HNRNPH1 16818672 1541001 Positive_regulation TP63 HNRNPH1 17254326 1620426 Positive_regulation TP63 HNRNPH1 25552899 743687 Positive_regulation TP63 IFNL1 PMC4126180 787248 Positive_regulation TP63 IL10 20204070 1213911 Positive_regulation TP63 IL10 23071691 2703744 Positive_regulation TP63 IL10 24165808 808966 Positive_regulation TP63 IL10 25187652 1621064 Positive_regulation TP63 IL12A 14699082 1530522 Positive_regulation TP63 IL12A 23226202 2723578 Positive_regulation TP63 IL12A 23472171 2764332 Positive_regulation TP63 IL12B 14699082 1530523 Positive_regulation TP63 IL12B 23149662 1919546 Positive_regulation TP63 IL12B 23226202 2723579 Positive_regulation TP63 IL12B 23472171 2764333 Positive_regulation TP63 IL15 23509806 180550 Positive_regulation TP63 IL18 21283810 2498306 Positive_regulation TP63 IL1R1 21876792 798880 Positive_regulation TP63 IL2 21283810 2498307 Positive_regulation TP63 IL23A 23149662 1919544 Positive_regulation TP63 IL4 10811870 1515477 Positive_regulation TP63 IL4 7836910 1592363 Positive_regulation TP63 IL6ST 19091128 3117564 Positive_regulation TP63 IRF1 25258544 1049956 Positive_regulation TP63 IRF8 19487420 1554887 Positive_regulation TP63 IRF8 25258544 1049955 Positive_regulation TP63 IRF8 9348310 1601827 Positive_regulation TP63 ITCH 23710361 1690490 Positive_regulation TP63 MAPK1 23334153 3217658 Positive_regulation TP63 MAPK10 23334153 3217659 Positive_regulation TP63 MAPK11 23334153 3217660 Positive_regulation TP63 MAPK12 23334153 3217661 Positive_regulation TP63 MAPK13 23334153 3217662 Positive_regulation TP63 MAPK14 23334153 3217663 Positive_regulation TP63 MAPK15 23334153 3217656 Positive_regulation TP63 MAPK3 23334153 3217664 Positive_regulation TP63 MAPK4 23334153 3217665 Positive_regulation TP63 MAPK6 23334153 3217666 Positive_regulation TP63 MAPK7 23334153 3217667 Positive_regulation TP63 MAPK8 23334153 3217668 Positive_regulation TP63 MAPK9 23334153 3217669 Positive_regulation TP63 MRE11A 24823795 2100817 Positive_regulation TP63 MYCN 24556696 572363 Positive_regulation TP63 MYCN 24556696 572382 Positive_regulation TP63 MYCN 24556696 572384 Positive_regulation TP63 MYD88 16365150 1538956 Positive_regulation TP63 MYD88 22102818 3054769 Positive_regulation TP63 NEDD4 24822180 190529 Positive_regulation TP63 NFIL3 24690414 132078 Positive_regulation TP63 NOS1 23226202 2723580 Positive_regulation TP63 NOS2 23226202 2723581 Positive_regulation TP63 NOS3 23226202 2723582 Positive_regulation TP63 NQO1 20613985 2454611 Positive_regulation TP63 NQO1 22249251 2146024 Positive_regulation TP63 OPN1LW 21931552 3053412 Positive_regulation TP63 PCBP1 23940783 2832404 Positive_regulation TP63 PCBP1 23940783 2832413 Positive_regulation TP63 PCBP1 23940783 2832420 Positive_regulation TP63 PDLIM7 20498633 2132336 Positive_regulation TP63 PPP1R13B 18676979 2035572 Positive_regulation TP63 PSMB9 20498633 2132342 Positive_regulation TP63 PSMB9 20498633 2132343 Positive_regulation TP63 PSMB9 20498633 2132344 Positive_regulation TP63 PSMB9 20498633 2132367 Positive_regulation TP63 PTBP1 16818672 1541002 Positive_regulation TP63 PTBP1 17254326 1620427 Positive_regulation TP63 PTBP1 25552899 743688 Positive_regulation TP63 PTBP2 16818672 1540999 Positive_regulation TP63 PTBP2 17254326 1620424 Positive_regulation TP63 PTBP2 25552899 743685 Positive_regulation TP63 PTX3 22852877 532919 Positive_regulation TP63 PTX4 22852877 532918 Positive_regulation TP63 RAB10 24165808 808967 Positive_regulation TP63 RAB12 24165808 808965 Positive_regulation TP63 RAB13 24165808 808968 Positive_regulation TP63 RAB14 24165808 808954 Positive_regulation TP63 RAB15 24165808 808961 Positive_regulation TP63 RAB17 24165808 808953 Positive_regulation TP63 RAB18 24165808 808949 Positive_regulation TP63 RAB19 24165808 808959 Positive_regulation TP63 RAB20 24165808 808956 Positive_regulation TP63 RAB21 24165808 808957 Positive_regulation TP63 RAB23 24165808 808951 Positive_regulation TP63 RAB24 24165808 808969 Positive_regulation TP63 RAB25 24165808 808955 Positive_regulation TP63 RAB26 24165808 808950 Positive_regulation TP63 RAB28 24165808 808970 Positive_regulation TP63 RAB30 24165808 808971 Positive_regulation TP63 RAB31 24165808 808972 Positive_regulation TP63 RAB32 24165808 808973 Positive_regulation TP63 RAB34 24165808 808952 Positive_regulation TP63 RAB35 24165808 808974 Positive_regulation TP63 RAB36 24165808 808975 Positive_regulation TP63 RAB37 24165808 808964 Positive_regulation TP63 RAB38 24165808 808976 Positive_regulation TP63 RAB41 24165808 808958 Positive_regulation TP63 RAB42 24165808 808963 Positive_regulation TP63 RAB43 24165808 808960 Positive_regulation TP63 RAB44 24165808 808962 Positive_regulation TP63 RABEPK 23226202 2723577 Positive_regulation TP63 RAD51 24823795 2100818 Positive_regulation TP63 RBM5 22102818 3054750 Positive_regulation TP63 S100A2 24556685 572226 Positive_regulation TP63 SETD8 22117221 770914 Positive_regulation TP63 SOX2 19801978 1948785 Positive_regulation TP63 TLR1 17371930 1544919 Positive_regulation TP63 TLR1 17371930 1544949 Positive_regulation TP63 TLR10 17371930 1544927 Positive_regulation TP63 TLR10 17371930 1544957 Positive_regulation TP63 TLR2 17371930 1544920 Positive_regulation TP63 TLR2 17371930 1544950 Positive_regulation TP63 TLR2 21876792 798877 Positive_regulation TP63 TLR3 17371930 1544921 Positive_regulation TP63 TLR3 17371930 1544951 Positive_regulation TP63 TLR3 21876792 798878 Positive_regulation TP63 TLR4 17371930 1544922 Positive_regulation TP63 TLR4 17371930 1544952 Positive_regulation TP63 TLR4 21152080 2486104 Positive_regulation TP63 TLR4 21809339 808412 Positive_regulation TP63 TLR5 17371930 1544923 Positive_regulation TP63 TLR5 17371930 1544953 Positive_regulation TP63 TLR5 21876792 798879 Positive_regulation TP63 TLR6 17371930 1544928 Positive_regulation TP63 TLR6 17371930 1544958 Positive_regulation TP63 TLR7 17371930 1544924 Positive_regulation TP63 TLR7 17371930 1544954 Positive_regulation TP63 TLR7 21152080 2486105 Positive_regulation TP63 TLR8 17371930 1544925 Positive_regulation TP63 TLR8 17371930 1544955 Positive_regulation TP63 TLR9 17371930 1544926 Positive_regulation TP63 TLR9 17371930 1544956 Positive_regulation TP63 TNF 11157054 1518362 Positive_regulation TP63 TNF 11157054 1518378 Positive_regulation TP63 TNF 25384035 3024622 Positive_regulation TP63 TNF 9841916 1604730 Positive_regulation TP63 TNFSF10 24367714 2372345 Positive_regulation TP63 TNFSF11 22294048 1918596 Positive_regulation TP63 TP53 18660513 2035452 Positive_regulation TP63 TP53 22580601 2146905 Positive_regulation TP63 TP53 23420876 1570858 Positive_regulation TP63 TP53 24709709 617192 Positive_regulation TP63 TP53 24822180 190497 Positive_regulation TP63 TP53 24823795 2100816 Positive_regulation TP63 TP53BP2 18676979 2035571 Positive_regulation TP63 TRAF6 21854594 333162 Positive_regulation TP63 WWP1 24822180 190528 Positive_regulation TP63 YAP1 24621512 2933493 Positive_regulation TP63 ZEB1 20041147 2435479 Positive_regulation TPI1 IL1B 10704077 1736879 Positive_regulation TPM1 ITGA9 24391925 2904970 Positive_regulation TPM1 TMOD1 12975349 1297055 Positive_regulation TPM1 TMOD1 20737540 694946 Positive_regulation TPM1 TMOD1 2380244 1405835 Positive_regulation TPM1 TMOD1 7730404 1439830 Positive_regulation TPM1 TMOD1 7730404 1439831 Positive_regulation TPM1 TMOD1 8421055 1448488 Positive_regulation TPM2 TMOD1 12975349 1297056 Positive_regulation TPM2 TMOD1 20737540 694947 Positive_regulation TPM2 TMOD1 2380244 1405839 Positive_regulation TPM2 TMOD1 7730404 1439838 Positive_regulation TPM2 TMOD1 7730404 1439839 Positive_regulation TPM2 TMOD1 8421055 1448489 Positive_regulation TPM3 TMOD1 12975349 1297057 Positive_regulation TPM3 TMOD1 20737540 694948 Positive_regulation TPM3 TMOD1 2380244 1405843 Positive_regulation TPM3 TMOD1 7730404 1439846 Positive_regulation TPM3 TMOD1 7730404 1439847 Positive_regulation TPM3 TMOD1 8421055 1448490 Positive_regulation TPM4 TMOD1 12975349 1297058 Positive_regulation TPM4 TMOD1 20737540 694949 Positive_regulation TPM4 TMOD1 2380244 1405847 Positive_regulation TPM4 TMOD1 7730404 1439854 Positive_regulation TPM4 TMOD1 7730404 1439855 Positive_regulation TPM4 TMOD1 8421055 1448491 Positive_regulation TPPP MMP7 21771347 3119762 Positive_regulation TPT1 TMEM100 24465583 2910892 Positive_regulation TPT1 TMEM156 24465583 2910910 Positive_regulation TPT1 TMEM211 24465583 2910990 Positive_regulation TPT1 TMEM213 24465583 2910927 Positive_regulation TPX2 TNF 20967264 2478609 Positive_regulation TRADD TNF 17567906 370595 Positive_regulation TRADD TNF 23429285 559992 Positive_regulation TRADD TNF 24025841 1990959 Positive_regulation TRADD TNF 25558224 2007538 Positive_regulation TRAF1 TNF 11696595 1521626 Positive_regulation TRAF1 TNF 11696595 1521647 Positive_regulation TRAF1 TNF 16115325 1036150 Positive_regulation TRAF1 TNF 20413583 2053225 Positive_regulation TRAF1 TNF 21876738 2547138 Positive_regulation TRAF1 TNF 22679495 2650120 Positive_regulation TRAF1 TNF 23239116 1239182 Positive_regulation TRAF1 TNF 24586810 2927097 Positive_regulation TRAF1 TNF 24600451 911360 Positive_regulation TRAF1 TNF 24600451 911370 Positive_regulation TRAF1 TNF 24600451 911371 Positive_regulation TRAF1 TNF 24600451 911372 Positive_regulation TRAF1 TNF 24600451 911397 Positive_regulation TRAF2 SPHK1 22615770 2643589 Positive_regulation TRAF2 TNF 12370254 1524972 Positive_regulation TRAF2 TNF 19918265 609837 Positive_regulation TRAF2 TNF 19918265 609868 Positive_regulation TRAF2 TNF 19918265 609890 Positive_regulation TRAF2 TNF 19918265 609909 Positive_regulation TRAF2 TNF 19918265 609930 Positive_regulation TRAF2 TNF 20413583 2053233 Positive_regulation TRAF2 TNF 21119000 1783891 Positive_regulation TRAF2 TNF 21247879 2060227 Positive_regulation TRAF2 TNF 22679495 2650121 Positive_regulation TRAF2 TNF 23239116 1239183 Positive_regulation TRAF2 TNF 23429285 559994 Positive_regulation TRAF2 TNF 23762085 637602 Positive_regulation TRAF2 TNF 24502696 1233035 Positive_regulation TRAF2 TNF 24502696 1233215 Positive_regulation TRAF2 TNF 25143800 2229920 Positive_regulation TRAF2 TNF 9763618 1604546 Positive_regulation TRAF2 TNF 9763618 1604548 Positive_regulation TRAF3 EPHB2 24378539 1574349 Positive_regulation TRAF3 TLR7 23508732 906386 Positive_regulation TRAF3 TLR7 23603814 1962760 Positive_regulation TRAF3 TLR7 23603814 1963027 Positive_regulation TRAF3 TLR7 25161655 913926 Positive_regulation TRAF3 TNF 20413583 2053234 Positive_regulation TRAF3 TNF 22679495 2650122 Positive_regulation TRAF3 TNF 23239116 1239184 Positive_regulation TRAF3IP2 TNF 23116200 127072 Positive_regulation TRAF4 TNF 20413583 2053235 Positive_regulation TRAF4 TNF 22679495 2650123 Positive_regulation TRAF4 TNF 23239116 1239185 Positive_regulation TRAF5 TNF 20413583 2053236 Positive_regulation TRAF5 TNF 22679495 2650124 Positive_regulation TRAF5 TNF 23042150 1957919 Positive_regulation TRAF5 TNF 23239116 1239186 Positive_regulation TRAF6 ARSA 18411340 1550455 Positive_regulation TRAF6 EPHB2 19305426 2124958 Positive_regulation TRAF6 EPHB2 20100871 1557338 Positive_regulation TRAF6 MAP2K6 12186654 994887 Positive_regulation TRAF6 TLR7 18268035 1549193 Positive_regulation TRAF6 TLR7 19668221 1952701 Positive_regulation TRAF6 TLR7 19668221 1952736 Positive_regulation TRAF6 TLR7 20929569 403326 Positive_regulation TRAF6 TLR7 23251221 637115 Positive_regulation TRAF6 TLR7 23514422 1683660 Positive_regulation TRAF6 TLR7 23565116 906714 Positive_regulation TRAF6 TLR7 23603814 1962956 Positive_regulation TRAF6 TLR7 24252328 178837 Positive_regulation TRAF6 TLR7 25161655 913930 Positive_regulation TRAF6 TNF 18060870 144939 Positive_regulation TRAF6 TNF 20100871 1557337 Positive_regulation TRAF6 TNF 20413583 2053237 Positive_regulation TRAF6 TNF 22249448 1566890 Positive_regulation TRAF6 TNF 22679495 2650125 Positive_regulation TRAF6 TNF 23239116 1239187 Positive_regulation TRAF6 TNF 23762085 637556 Positive_regulation TRAF6 TNF 25025000 1235444 Positive_regulation TRAF6 TNFSF10 22719861 2653284 Positive_regulation TRAF6 TNFSF10 22719861 2653339 Positive_regulation TRAF6 TNS1 25009550 970904 Positive_regulation TRAF6 TP63 21854594 333161 Positive_regulation TRAF7 TNF 20413583 2053238 Positive_regulation TRAF7 TNF 22679495 2650126 Positive_regulation TRAF7 TNF 23239116 1239188 Positive_regulation TRAP1 TNF 11044363 418039 Positive_regulation TRAT1 TLR7 23429360 838508 Positive_regulation TREM1 IL1B 20498845 2451118 Positive_regulation TREM1 TLR7 24842612 2971795 Positive_regulation TREM1 TNF 23861562 1754192 Positive_regulation TREM1 TNF 24350219 972848 Positive_regulation TREM2 EPHB2 15728241 1534815 Positive_regulation TREM2 EPHB2 19399172 2415438 Positive_regulation TRG ABCA12 19920924 742357 Positive_regulation TRIB1 GPR115 12537564 995051 Positive_regulation TRIB1 GPR132 12537564 995040 Positive_regulation TRIB1 GPR87 12537564 995120 Positive_regulation TRIB3 PGC 19366863 708268 Positive_regulation TRIM21 TLR7 22479513 2615656 Positive_regulation TRIM21 TLR7 22701487 1144880 Positive_regulation TRIM21 TLR7 22701487 1144905 Positive_regulation TRIM21 TLR7 23304190 637146 Positive_regulation TRIM21 TLR7 25084355 2994398 Positive_regulation TRIM21 TLR7 25084355 2994409 Positive_regulation TRIM24 RARB 23717505 2797908 Positive_regulation TRIM26 FAS 16080799 248879 Positive_regulation TRIM28 ZFP57 PMC3848115 3125617 Positive_regulation TRIM31 TNF 23936368 2830200 Positive_regulation TRIM33 EPHB2 21572418 1925863 Positive_regulation TRIM33 EPHB2 21860657 813122 Positive_regulation TRIM4 KRT38 21977036 1085973 Positive_regulation TRIM63 FBXO32 24647719 1239287 Positive_regulation TRIM63 FOXO1 19216724 659136 Positive_regulation TRIM63 FOXO1 21483870 2512531 Positive_regulation TRIM63 FOXO1 21798082 3160148 Positive_regulation TRIM63 FOXO1 23555761 2775252 Positive_regulation TRIM63 FOXO1 24454908 2910305 Positive_regulation TRIM63 FOXO1 24971321 193324 Positive_regulation TRIM63 FOXO1 25032690 2990175 Positive_regulation TRIM63 FOXO1 25276226 1651027 Positive_regulation TRIM63 FOXO1 25294954 1762715 Positive_regulation TRIM63 TNF 19216724 659125 Positive_regulation TRIM63 TNF 23300968 2737663 Positive_regulation TRIM63 TNF 23499576 3204095 Positive_regulation TRIM63 TNF 25566431 1498388 Positive_regulation TRIM8 TNF 23152791 2716292 Positive_regulation TRIM8 TNF 23152791 2716293 Positive_regulation TRIO TNF 23789107 169875 Positive_regulation TRIP10 TLR7 22945920 1568864 Positive_regulation TRIP11 TLR7 22945920 1568874 Positive_regulation TRIP12 TLR7 22945920 1568884 Positive_regulation TRIP13 TLR7 22945920 1568894 Positive_regulation TRIP4 TLR7 22945920 1568904 Positive_regulation TRIP6 TLR7 22945920 1568914 Positive_regulation TRNAE1 MMP28 20418905 2129547 Positive_regulation TRNAE1 MMP28 20418905 2129548 Positive_regulation TRNAE1 MMP7 20418905 2129579 Positive_regulation TRNAE1 MMP7 20418905 2129580 Positive_regulation TRNAI1 EPHB2 21042538 2479711 Positive_regulation TRNAN1 RNASE1 19729507 2047355 Positive_regulation TRNAN1 RNASE7 19729507 2047363 Positive_regulation TRO CCND1 24091475 2184955 Positive_regulation TRPA1 TLR7 25139109 1843248 Positive_regulation TRPC3 IL1B 17570168 395256 Positive_regulation TRPC3 IL1B 17570168 395257 Positive_regulation TRPC3 TNF 20068131 712462 Positive_regulation TRPC6 HRH1 24709960 618010 Positive_regulation TRPC6 TNF 20068131 712463 Positive_regulation TRPV1 EPHB2 24381558 963164 Positive_regulation TRPV1 HRH1 23476696 817472 Positive_regulation TRPV1 TNF 19531269 1897239 Positive_regulation TRPV1 TNF 19695100 1897440 Positive_regulation TRPV1 TNF 19695100 1897441 Positive_regulation TRPV1 TNF 19695100 1897446 Positive_regulation TRPV1 TNF 19695100 1897447 Positive_regulation TRPV1 TNF 19695100 1897451 Positive_regulation TRPV1 TNF 19695100 1897456 Positive_regulation TRPV1 TNF 21794120 1898394 Positive_regulation TRPV4 TNF 19695100 1897443 Positive_regulation TRPV4 TNF 19695100 1897444 Positive_regulation TRPV4 TNF 19695100 1897448 Positive_regulation TRPV4 TNF 19695100 1897453 Positive_regulation TRPV4 TNF 19695100 1897457 Positive_regulation TRPV6 CYP24A1 19779013 83834 Positive_regulation TSC1 EPHB2 18302728 359875 Positive_regulation TSC2 EPHB2 18302728 359876 Positive_regulation TSC2 EPHB2 19966866 2128527 Positive_regulation TSC2 EPHB2 20169078 2441079 Positive_regulation TSC2 EPHB2 21200439 2489521 Positive_regulation TSC2 EPHB2 21763421 613337 Positive_regulation TSC2 EPHB2 21904669 798998 Positive_regulation TSC2 EPHB2 24612393 1692482 Positive_regulation TSC2 EPHB2 25295009 966010 Positive_regulation TSC22D3 FOXO1 23516608 2768725 Positive_regulation TSG101 NEDD9 23305486 3121266 Positive_regulation TSLP CCL17 24498539 1708762 Positive_regulation TSLP CCL17 25400924 1037351 Positive_regulation TSLP CCL17 25546419 3036561 Positive_regulation TSLP TLR7 24204367 909753 Positive_regulation TSLP TLR7 24335833 1736602 Positive_regulation TSLP TNF 18724870 524848 Positive_regulation TSLP TNF 21339327 1562668 Positive_regulation TSLP TNF 22205837 1712057 Positive_regulation TSLP TNF 25198676 3006121 Positive_regulation TSLP TNF 25198676 3006122 Positive_regulation TSLP TNF 25546419 3036551 Positive_regulation TSLP TNF PMC3353466 35179 Positive_regulation TSPAN1 EZR 21961047 2557469 Positive_regulation TSPAN1 ITGAL 24832104 2970489 Positive_regulation TSPAN1 MMP2 10491398 1249625 Positive_regulation TSPAN1 MSN 21961047 2557470 Positive_regulation TSPAN1 RDX 21961047 2557471 Positive_regulation TSPAN1 RHO 24040034 2845320 Positive_regulation TSPAN1 TIMP1 22701711 2652162 Positive_regulation TSPAN10 ITGAL 24832104 2970498 Positive_regulation TSPAN11 ITGAL 24832104 2970500 Positive_regulation TSPAN12 ITGAL 24832104 2970493 Positive_regulation TSPAN13 ITGAL 24832104 2970494 Positive_regulation TSPAN14 ITGAL 24832104 2970496 Positive_regulation TSPAN15 ITGAL 24832104 2970495 Positive_regulation TSPAN16 ITGAL 24832104 2970499 Positive_regulation TSPAN17 ITGAL 24832104 2970485 Positive_regulation TSPAN18 ITGAL 24832104 2970491 Positive_regulation TSPAN19 ITGAL 24832104 2970501 Positive_regulation TSPAN2 ITGAL 24832104 2970490 Positive_regulation TSPAN3 ITGAL 24832104 2970487 Positive_regulation TSPAN31 ITGAL 24832104 2970479 Positive_regulation TSPAN32 ITGAL 24832104 2970484 Positive_regulation TSPAN33 ITGAL 24832104 2970497 Positive_regulation TSPAN4 ITGAL 24832104 2970483 Positive_regulation TSPAN5 ITGAL 24832104 2970488 Positive_regulation TSPAN6 ITGAL 24832104 2970482 Positive_regulation TSPAN7 ITGAL 24832104 2970480 Positive_regulation TSPAN8 ITGAL 24832104 2970481 Positive_regulation TSPAN9 ITGAL 24832104 2970492 Positive_regulation TTN FHL1 24376425 963134 Positive_regulation TTN MYH16 2681227 1423738 Positive_regulation TTN MYH3 2681227 1423745 Positive_regulation TUB CDK1 21573187 2522925 Positive_regulation TUB IGF1 25031889 788250 Positive_regulation TUB INS 22966070 724641 Positive_regulation TUB INS 22966070 724642 Positive_regulation TUB INS 22966070 724643 Positive_regulation TUB INS 22966070 724644 Positive_regulation TUB INS 22966070 724655 Positive_regulation TUB INS 22966070 724658 Positive_regulation TUB INS 22966070 724665 Positive_regulation TUB INS 22966070 724666 Positive_regulation TUB INS 25031889 788249 Positive_regulation TUB INS 25031889 788251 Positive_regulation TUB INS 25031889 788254 Positive_regulation TUB LEP 22966070 724645 Positive_regulation TUB LEP 22966070 724646 Positive_regulation TUB LEP 22966070 724656 Positive_regulation TUB LEP 22966070 724659 Positive_regulation TUB LEP 22966070 724660 Positive_regulation TUB LEP 22966070 724667 Positive_regulation TUB LEP 22966070 724668 Positive_regulation TUB LEP 22966070 724669 Positive_regulation TUB LEP 22966070 724675 Positive_regulation TUB LGALS1 21573187 2522930 Positive_regulation TUB TULP1 24375934 1035379 Positive_regulation TUBA1A NES 15251038 277775 Positive_regulation TUBA4A NES 15251038 277760 Positive_regulation TUBB NES 15251038 277776 Positive_regulation TUBB3 MAP2K6 21071418 2058041 Positive_regulation TUBG1 NES 15251038 277761 Positive_regulation TWIST1 CLU 25277175 2202945 Positive_regulation TWIST1 STAT4 22566829 898649 Positive_regulation TWIST1 STAT4 22969750 877116 Positive_regulation TWIST1 TGM2 22225906 469613 Positive_regulation TWIST1 TLR7 24322444 1122004 Positive_regulation TWIST2 HBEGF 24136232 568200 Positive_regulation TWIST2 HBEGF 24136232 568201 Positive_regulation TXN MAP2K6 24376827 2902399 Positive_regulation TXN PGC 25375380 579015 Positive_regulation TXN TGM2 24130874 2867435 Positive_regulation TXN TNF 11178114 98208 Positive_regulation TXN TNF 17324256 320022 Positive_regulation TXNDC9 FOXO1 22654904 680310 Positive_regulation TXNIP FOXO1 24112473 270026 Positive_regulation TXNIP FOXO1 24112473 270038 Positive_regulation TXNIP FOXO1 24112473 270044 Positive_regulation TXNIP S100B 22474421 832800 Positive_regulation TYR ADRB2 22073124 2569275 Positive_regulation TYR CAPN8 24394804 1940246 Positive_regulation TYR CCND1 22927910 2680980 Positive_regulation TYR CST6 23966469 1817926 Positive_regulation TYR EPHB2 20565770 360382 Positive_regulation TYR EPHB2 23216800 2113712 Positive_regulation TYR EPHB2 24763051 574225 Positive_regulation TYR HBEGF 19531065 3187188 Positive_regulation TYR IL1B 22792188 2661253 Positive_regulation TYR TNF 20308428 1373819 Positive_regulation TYR TNF 22144946 928807 Positive_regulation TYRP1 EPHB2 24129178 1113299 Positive_regulation TYRP1 MAP2K6 24129178 1113305 Positive_regulation TYRP1 TGM2 25009701 206378 Positive_regulation TYRP1 TNF 23013558 395942 Positive_regulation U2AF1 RNASE1 22730292 2078965 Positive_regulation U2AF2 RNASE1 22730292 2078966 Positive_regulation UBA52 FHL1 15113405 231119 Positive_regulation UBC TNFSF10 24147007 2869103 Positive_regulation UBE2N SNCAIP 24023840 2843803 Positive_regulation UBE2V1 EPHB2 19305426 2124959 Positive_regulation UBE2V1 TNFSF10 22719861 2653286 Positive_regulation UBE2V1 TNS1 25009550 970905 Positive_regulation UBL3 MUC16 22254114 2116135 Positive_regulation UCA1 ETS2 24069250 2852263 Positive_regulation UCA1 ETS2 24069250 2852264 Positive_regulation UCA1 ETS2 24069250 2852277 Positive_regulation UCA1 ETS2 24069250 2852282 Positive_regulation UCA1 ETS2 24069250 2852286 Positive_regulation UCA1 PTBP1 24457952 571266 Positive_regulation UCA1 PTBP1 24457952 571267 Positive_regulation UCA1 PTBP1 24457952 571307 Positive_regulation UCN TNF 23846219 563940 Positive_regulation UCP1 FOXA1 22238690 2587074 Positive_regulation UCP1 FOXA1 22238690 2587082 Positive_regulation UCP1 FOXA1 22238690 2587088 Positive_regulation UCP1 PGC 15760270 2257973 Positive_regulation UCP1 PGC 17090215 2262221 Positive_regulation UCP1 PGC 17389766 3071531 Positive_regulation UCP1 PGC 17389766 3071541 Positive_regulation UCP1 PGC 19833890 711535 Positive_regulation UCP1 PGC 22035495 520083 Positive_regulation UCP1 PGC 22035495 520085 Positive_regulation UCP1 PGC 22237023 1988083 Positive_regulation UCP1 PGC 22389706 2607961 Positive_regulation UCP1 PGC 22389706 2608002 Positive_regulation UCP1 PGC 22649407 875234 Positive_regulation UCP1 PGC 22654820 876072 Positive_regulation UCP1 PGC 23093952 3076011 Positive_regulation UCP1 PGC 23093952 3076012 Positive_regulation UCP1 PGC 23093952 3076032 Positive_regulation UCP1 PGC 23093952 3076041 Positive_regulation UCP1 PGC 23093952 3076045 Positive_regulation UCP1 PGC 23107305 1725070 Positive_regulation UCP1 PGC 23317303 89680 Positive_regulation UCP1 PGC 23455155 2110746 Positive_regulation UCP1 PGC 23455155 2110748 Positive_regulation UCP1 PGC 23717545 2798140 Positive_regulation UCP1 PGC 23717545 2798141 Positive_regulation UCP1 PGC 23717545 2798142 Positive_regulation UCP1 PGC 23717545 2798143 Positive_regulation UCP1 PGC 23748190 1140590 Positive_regulation UCP1 PGC 23895241 213848 Positive_regulation UCP1 PGC 23964012 781874 Positive_regulation UCP1 PGC 24059847 290132 Positive_regulation UCP1 PGC 24669882 2113989 Positive_regulation UCP1 PGC 25071841 896344 Positive_regulation UCP1 PGC 25566082 967308 Positive_regulation UCP1 PGC 25610428 881537 Positive_regulation UCP2 ANGPT1 24642125 614199 Positive_regulation UCP2 ANGPT1 24642125 614200 Positive_regulation UCP2 ANGPT1 24642125 614218 Positive_regulation UCP2 IL1B 17961234 626791 Positive_regulation UCP2 PGC 20566666 715343 Positive_regulation UCP2 PGC 22742515 212912 Positive_regulation UCP2 PGC 25071841 896345 Positive_regulation UCP2 TNF 15026812 424419 Positive_regulation UCP2 TNF 15689240 2112206 Positive_regulation UCP2 TNF 23826253 2811720 Positive_regulation UCP3 PGC 19435887 1165967 Positive_regulation UCP3 PGC 20566666 715344 Positive_regulation UCP3 PGC 22353542 2113160 Positive_regulation UFD1L PGC 21475702 1238380 Positive_regulation UGCG FOXO1 22888331 903189 Positive_regulation UGCG JAG1 11015435 1517307 Positive_regulation UGCG JAG1 23049531 904421 Positive_regulation UGCG RCAN1 19725972 1646637 Positive_regulation UGCG TNF 20439544 1558179 Positive_regulation UGCG TNF 20439544 1558189 Positive_regulation UGCG TNF 23049873 2699758 Positive_regulation UGCG TNF 23717489 2797856 Positive_regulation UGGT2 UGT1A7 22669291 650418 Positive_regulation UGT1A1 UGT1A7 22669291 650376 Positive_regulation UGT1A3 UGT1A7 22669291 650384 Positive_regulation UGT1A6 AHR 22242167 2587343 Positive_regulation UGT1A6 ARNT 22242167 2587345 Positive_regulation UGT1A6 ARSA 17074929 1543128 Positive_regulation UGT1A6 CDK9 22242167 2587342 Positive_regulation UGT1A6 IL6ST 22242167 2587344 Positive_regulation UGT1A6 SOD1 20041016 1498091 Positive_regulation UGT1A6 SOD2 20041016 1498092 Positive_regulation UGT1A6 SOD3 20041016 1498093 Positive_regulation UGT1A7 DONSON 22669291 650398 Positive_regulation UGT1A7 UGGT2 22669291 650397 Positive_regulation UGT1A7 UGT1A1 22669291 650393 Positive_regulation UGT1A7 UGT1A3 22669291 650394 Positive_regulation UGT1A7 UGT1A9 22669291 650395 Positive_regulation UGT1A7 UGT2B7 22669291 650396 Positive_regulation UGT1A9 UGT1A7 22669291 650401 Positive_regulation UGT2B15 FOXA1 23919967 2184007 Positive_regulation UGT2B7 UGT1A7 22669291 650412 Positive_regulation UGT8 TNF 16100442 1634465 Positive_regulation UGT8 TNF 16100442 1634624 Positive_regulation UHRF1 TNFSF10 24941171 2980826 Positive_regulation UMOD TLR7 22384111 2604300 Positive_regulation UMOD TLR7 PMC3760629 1605999 Positive_regulation UMOD TNF 22507528 1661587 Positive_regulation UMOD TNF 23799016 2806681 Positive_regulation UNC119 SYT8 22808098 2664384 Positive_regulation UNC13D STAT4 24842371 1576366 Positive_regulation UNC13D STAT4 24842371 1576367 Positive_regulation UNC13D STAT4 24842371 1576368 Positive_regulation UNC13D STAT4 24842371 1576375 Positive_regulation UNC45B MYH16 24068325 1818873 Positive_regulation UNC45B MYH3 24068325 1818880 Positive_regulation UNC50 SYT8 22808098 2664407 Positive_regulation UNC5B AGAP2 21460185 1789315 Positive_regulation UNC5B AGAP2 21460185 1789316 Positive_regulation UNC5B AGAP2 21460185 1789355 Positive_regulation UNC5B AGAP2 21460185 1789370 Positive_regulation UNC5B AGAP2 21460185 1789371 Positive_regulation UNC5B AGAP2 21460185 1789380 Positive_regulation UNC5B AGAP2 23770988 18001 Positive_regulation UNC5B AKT1 21460185 1789245 Positive_regulation UNC5B AKT1 21460185 1789246 Positive_regulation UNC5B AKT1 21460185 1789306 Positive_regulation UNC5B AKT1 21460185 1789356 Positive_regulation UNC5B AKT1 23770988 18002 Positive_regulation UNC5B AKT2 21460185 1789247 Positive_regulation UNC5B AKT2 21460185 1789248 Positive_regulation UNC5B AKT2 21460185 1789307 Positive_regulation UNC5B AKT2 21460185 1789357 Positive_regulation UNC5B AKT2 23770988 18003 Positive_regulation UNC5B AKT3 21460185 1789249 Positive_regulation UNC5B AKT3 21460185 1789250 Positive_regulation UNC5B AKT3 21460185 1789308 Positive_regulation UNC5B AKT3 21460185 1789358 Positive_regulation UNC5B AKT3 23770988 18004 Positive_regulation UNC5B DAPK1 15956977 426251 Positive_regulation UNC5B DAPK2 15956977 426252 Positive_regulation UNC5B DAPK3 15956977 426253 Positive_regulation UNC5B HLX 24988463 2986252 Positive_regulation UNC5B IL7 24369474 639392 Positive_regulation UNC5B MYC 21460185 1789372 Positive_regulation UNC5B NR0B1 24720832 1483002 Positive_regulation UNC5B NTN1 21460185 1789280 Positive_regulation UNC5B NTN1 21460185 1789309 Positive_regulation UNC5B NTN1 21460185 1789339 Positive_regulation UNC5B NTN1 21460185 1789414 Positive_regulation UNC5B NTN1 24720832 1483000 Positive_regulation UNC5B PI3 21460185 1789408 Positive_regulation UNC5B PI3 21460185 1789415 Positive_regulation UNC5B RGMA 25374504 939316 Positive_regulation UNC5B RND1 19492039 2417965 Positive_regulation UNC79 CEACAM6 18336069 2264316 Positive_regulation UNC79 SYT8 22808098 2664466 Positive_regulation UNC80 SYT8 22808098 2664501 Positive_regulation UNC93B1 TLR7 20865117 3048637 Positive_regulation UNC93B1 TLR7 23426999 748755 Positive_regulation UNC93B1 TLR7 23426999 748756 Positive_regulation UPF1 RNASE1 23826386 2812450 Positive_regulation UPF1 RNASE1 25053839 2103143 Positive_regulation UPF1 RNASE1 25200086 2104788 Positive_regulation UPF1 RNASE7 25200086 2104796 Positive_regulation UPF2 RNASE1 25200086 2104704 Positive_regulation UPF2 RNASE7 25200086 2104712 Positive_regulation UPF3B RNASE1 25200086 2104728 Positive_regulation UPF3B RNASE7 25200086 2104736 Positive_regulation UPK1B FOXA1 22590586 2642254 Positive_regulation UPK3A FOXA1 22590586 2642255 Positive_regulation UPK3B CAPN8 19090995 385353 Positive_regulation UPK3B CAPN8 21943307 1892458 Positive_regulation UPK3B EPHB2 23734197 2799593 Positive_regulation UPK3B FOXA1 22590586 2642256 Positive_regulation UPK3B TLR7 23967307 2836084 Positive_regulation UPK3B TNF 21736731 1898337 Positive_regulation UPK3B TNF 23285065 2732365 Positive_regulation UPK3B TNF 23700396 1039655 Positive_regulation UPK3B TP63 23297419 1206032 Positive_regulation UQCRFS1 PGC 25610371 872912 Positive_regulation USP2 CCND1 23236372 2726025 Positive_regulation USP2 PGC 22447855 722475 Positive_regulation USP2 PGC 22447855 722480 Positive_regulation USP2 PGC 22447855 722487 Positive_regulation USP2 PGC 23133608 2713151 Positive_regulation USP2 PGC 23133608 2713152 Positive_regulation USP2 PGC 23133608 2713153 Positive_regulation USP25 TNF 23042150 1957920 Positive_regulation UTP15 PLAT 21519856 3090635 Positive_regulation UTP18 PLAT 21519856 3090633 Positive_regulation UTP20 PLAT 21519856 3090631 Positive_regulation UTP23 PLAT 21519856 3090636 Positive_regulation UTP3 PLAT 21519856 3090634 Positive_regulation UTP6 PLAT 21519856 3090632 Positive_regulation UTRN PGC 24447845 3163260 Positive_regulation UTRN PGC 24447845 3163261 Positive_regulation UTRN PGC 24447845 3163266 Positive_regulation UTRN PGC 24447845 3163268 Positive_regulation UTRN PGC 24447845 3163269 Positive_regulation UTS2 EPHB2 20859543 3208908 Positive_regulation UTS2 EPHB2 20859543 3208986 Positive_regulation UTS2 EPHB2 20859543 3208988 Positive_regulation UTS2 EPHB2 20859543 3209006 Positive_regulation UTS2R EPHB2 20859543 3208939 Positive_regulation UVRAG PRODH 23861960 2821068 Positive_regulation UXT TNF 17620405 1341838 Positive_regulation VAMP3 RAB31 20347926 833532 Positive_regulation VASP GAB3 21041447 1381583 Positive_regulation VAV1 CCND1 25313137 2205100 Positive_regulation VAV1 ITGAL 12885870 1528128 Positive_regulation VAV1 ITGAL 12885870 1528132 Positive_regulation VAV1 ITGAL 12885870 1528133 Positive_regulation VAV1 ITGAL 12885870 1528138 Positive_regulation VAV1 ITGB2 12885870 1528126 Positive_regulation VAV1 ITGB2 12885870 1528127 Positive_regulation VAV1 ITGB2 12885870 1528129 Positive_regulation VAV1 ITGB2 12885870 1528130 Positive_regulation VAV1 ITGB2 16203869 1538029 Positive_regulation VAV2 EFNB1 23143520 1967874 Positive_regulation VAV2 EFNB1 23143520 1967887 Positive_regulation VAV2 IL6R 23935450 2283769 Positive_regulation VAV2 PECAM1 23733346 1405461 Positive_regulation VAV3 IL6R 23935450 2283770 Positive_regulation VCAM1 CFI 22970174 2687483 Positive_regulation VCAM1 CHI3L1 7540655 1590363 Positive_regulation VCAM1 EPHB2 22031842 2565351 Positive_regulation VCAM1 EPHB2 23626475 1715022 Positive_regulation VCAM1 EPHB2 23789107 169925 Positive_regulation VCAM1 F2R 18412955 110495 Positive_regulation VCAM1 GLP1R 24428883 510664 Positive_regulation VCAM1 IL1B 10958382 1737141 Positive_regulation VCAM1 IL1B 12537603 3103812 Positive_regulation VCAM1 IL1B 12537603 3103821 Positive_regulation VCAM1 IL1B 18472842 1742231 Positive_regulation VCAM1 IL1B 23130331 135981 Positive_regulation VCAM1 MAP2K6 23626475 1715028 Positive_regulation VCAM1 MAP2K6 23789107 169932 Positive_regulation VCAM1 MMP28 25525444 827371 Positive_regulation VCAM1 MMP7 25525444 827386 Positive_regulation VCAM1 MYH16 9490737 1466652 Positive_regulation VCAM1 MYH3 9490737 1466659 Positive_regulation VCAM1 NT5E 20181103 1625937 Positive_regulation VCAM1 TLR7 23110209 2707114 Positive_regulation VCAM1 TNF 10209034 1245467 Positive_regulation VCAM1 TNF 10958382 1737140 Positive_regulation VCAM1 TNF 11132773 1737240 Positive_regulation VCAM1 TNF 12438420 1525221 Positive_regulation VCAM1 TNF 12467526 1738283 Positive_regulation VCAM1 TNF 12537603 3103811 Positive_regulation VCAM1 TNF 12537603 3103820 Positive_regulation VCAM1 TNF 12810688 1527675 Positive_regulation VCAM1 TNF 1281211 1527727 Positive_regulation VCAM1 TNF 1281211 1527731 Positive_regulation VCAM1 TNF 1281211 1527732 Positive_regulation VCAM1 TNF 1281211 1527737 Positive_regulation VCAM1 TNF 12823845 99837 Positive_regulation VCAM1 TNF 12875662 247417 Positive_regulation VCAM1 TNF 12875662 247421 Positive_regulation VCAM1 TNF 1370496 1297711 Positive_regulation VCAM1 TNF 1383376 1528830 Positive_regulation VCAM1 TNF 15144561 648840 Positive_regulation VCAM1 TNF 15483345 1634370 Positive_regulation VCAM1 TNF 15498105 390231 Positive_regulation VCAM1 TNF 15642148 102417 Positive_regulation VCAM1 TNF 15694007 391918 Positive_regulation VCAM1 TNF 15694007 391919 Positive_regulation VCAM1 TNF 15809354 1535341 Positive_regulation VCAM1 TNF 16104828 2368414 Positive_regulation VCAM1 TNF 16336680 656506 Positive_regulation VCAM1 TNF 16702604 1540324 Positive_regulation VCAM1 TNF 17319106 3208377 Positive_regulation VCAM1 TNF 18096615 2032380 Positive_regulation VCAM1 TNF 18289377 2112390 Positive_regulation VCAM1 TNF 18366601 322482 Positive_regulation VCAM1 TNF 18472842 1742229 Positive_regulation VCAM1 TNF 18568424 3090165 Positive_regulation VCAM1 TNF 19132133 3074846 Positive_regulation VCAM1 TNF 19197380 1746470 Positive_regulation VCAM1 TNF 19228707 513361 Positive_regulation VCAM1 TNF 19228707 513362 Positive_regulation VCAM1 TNF 19228707 513365 Positive_regulation VCAM1 TNF 19296842 112993 Positive_regulation VCAM1 TNF 19419583 252603 Positive_regulation VCAM1 TNF 19597294 736292 Positive_regulation VCAM1 TNF 19707438 175839 Positive_regulation VCAM1 TNF 19707438 175842 Positive_regulation VCAM1 TNF 19736220 811443 Positive_regulation VCAM1 TNF 19736220 811444 Positive_regulation VCAM1 TNF 19736220 811448 Positive_regulation VCAM1 TNF 19930605 290767 Positive_regulation VCAM1 TNF 20069129 1213490 Positive_regulation VCAM1 TNF 20069129 1213494 Positive_regulation VCAM1 TNF 20181103 1625936 Positive_regulation VCAM1 TNF 20181103 1625960 Positive_regulation VCAM1 TNF 20181103 1625963 Positive_regulation VCAM1 TNF 20361002 2214369 Positive_regulation VCAM1 TNF 20368952 2114520 Positive_regulation VCAM1 TNF 20368952 2114521 Positive_regulation VCAM1 TNF 20368952 2114522 Positive_regulation VCAM1 TNF 20368952 2114524 Positive_regulation VCAM1 TNF 20368952 2114526 Positive_regulation VCAM1 TNF 20386708 2446392 Positive_regulation VCAM1 TNF 20463823 1078133 Positive_regulation VCAM1 TNF 20565944 626877 Positive_regulation VCAM1 TNF 20604932 119347 Positive_regulation VCAM1 TNF 20700422 3174626 Positive_regulation VCAM1 TNF 20700422 3174627 Positive_regulation VCAM1 TNF 20836881 508204 Positive_regulation VCAM1 TNF 20868490 1651265 Positive_regulation VCAM1 TNF 20967264 2478597 Positive_regulation VCAM1 TNF 21029292 590583 Positive_regulation VCAM1 TNF 21264293 2495221 Positive_regulation VCAM1 TNF 21371346 121705 Positive_regulation VCAM1 TNF 21403844 506731 Positive_regulation VCAM1 TNF 21423396 955248 Positive_regulation VCAM1 TNF 21572963 2520265 Positive_regulation VCAM1 TNF 21572963 2520266 Positive_regulation VCAM1 TNF 21572963 2520270 Positive_regulation VCAM1 TNF 21572963 2520271 Positive_regulation VCAM1 TNF 21572963 2520308 Positive_regulation VCAM1 TNF 21572963 2520314 Positive_regulation VCAM1 TNF 21788407 1564370 Positive_regulation VCAM1 TNF 21808585 1682053 Positive_regulation VCAM1 TNF 21863241 809876 Positive_regulation VCAM1 TNF 21872249 139269 Positive_regulation VCAM1 TNF 21966155 1681777 Positive_regulation VCAM1 TNF 21977451 730297 Positive_regulation VCAM1 TNF 21995855 627404 Positive_regulation VCAM1 TNF 21995855 627405 Positive_regulation VCAM1 TNF 21995855 627410 Positive_regulation VCAM1 TNF 22013533 1145399 Positive_regulation VCAM1 TNF 22031842 2565258 Positive_regulation VCAM1 TNF 22093181 1626435 Positive_regulation VCAM1 TNF 22125674 2115078 Positive_regulation VCAM1 TNF 22125674 2115082 Positive_regulation VCAM1 TNF 22128776 1724153 Positive_regulation VCAM1 TNF 22128776 1724156 Positive_regulation VCAM1 TNF 22128776 1724163 Positive_regulation VCAM1 TNF 22162719 633644 Positive_regulation VCAM1 TNF 22238605 2586652 Positive_regulation VCAM1 TNF 22247597 1490081 Positive_regulation VCAM1 TNF 22279375 2248277 Positive_regulation VCAM1 TNF 22431312 778571 Positive_regulation VCAM1 TNF 22536886 291984 Positive_regulation VCAM1 TNF 22536886 291985 Positive_regulation VCAM1 TNF 22536886 291992 Positive_regulation VCAM1 TNF 22536886 291993 Positive_regulation VCAM1 TNF 22536886 291997 Positive_regulation VCAM1 TNF 22536886 291998 Positive_regulation VCAM1 TNF 22536886 292000 Positive_regulation VCAM1 TNF 22536886 292001 Positive_regulation VCAM1 TNF 22536886 292003 Positive_regulation VCAM1 TNF 22536886 292004 Positive_regulation VCAM1 TNF 22553973 509079 Positive_regulation VCAM1 TNF 22615904 2644170 Positive_regulation VCAM1 TNF 22734001 1398621 Positive_regulation VCAM1 TNF 22754320 1095965 Positive_regulation VCAM1 TNF 22754320 1095969 Positive_regulation VCAM1 TNF 22931291 1231142 Positive_regulation VCAM1 TNF 22941285 15930 Positive_regulation VCAM1 TNF 23056947 1145838 Positive_regulation VCAM1 TNF 23071583 2703022 Positive_regulation VCAM1 TNF 23091461 959477 Positive_regulation VCAM1 TNF 23136554 1060886 Positive_regulation VCAM1 TNF 23185197 95318 Positive_regulation VCAM1 TNF 23190900 1631836 Positive_regulation VCAM1 TNF 23243449 816585 Positive_regulation VCAM1 TNF 23243449 816589 Positive_regulation VCAM1 TNF 23285008 2731508 Positive_regulation VCAM1 TNF 23285008 2731511 Positive_regulation VCAM1 TNF 23285008 2731515 Positive_regulation VCAM1 TNF 23285008 2731519 Positive_regulation VCAM1 TNF 23285008 2731523 Positive_regulation VCAM1 TNF 23285008 2731529 Positive_regulation VCAM1 TNF 23317476 1155716 Positive_regulation VCAM1 TNF 23317476 1155717 Positive_regulation VCAM1 TNF 23317476 1155727 Positive_regulation VCAM1 TNF 23317476 1155736 Positive_regulation VCAM1 TNF 23383064 2747763 Positive_regulation VCAM1 TNF 23422838 2115260 Positive_regulation VCAM1 TNF 23422838 2115261 Positive_regulation VCAM1 TNF 23422838 2115262 Positive_regulation VCAM1 TNF 23422838 2115264 Positive_regulation VCAM1 TNF 23422838 2115265 Positive_regulation VCAM1 TNF 23531541 1103750 Positive_regulation VCAM1 TNF 23551392 1480125 Positive_regulation VCAM1 TNF 23671702 2792484 Positive_regulation VCAM1 TNF 23690670 1752082 Positive_regulation VCAM1 TNF 23728723 17874 Positive_regulation VCAM1 TNF 23728723 17875 Positive_regulation VCAM1 TNF 23728723 17879 Positive_regulation VCAM1 TNF 23728723 17892 Positive_regulation VCAM1 TNF 23728723 17893 Positive_regulation VCAM1 TNF 23728723 17896 Positive_regulation VCAM1 TNF 23762160 820140 Positive_regulation VCAM1 TNF 23762160 820143 Positive_regulation VCAM1 TNF 23770053 1498341 Positive_regulation VCAM1 TNF 23785355 878867 Positive_regulation VCAM1 TNF 23789107 169877 Positive_regulation VCAM1 TNF 23789107 169878 Positive_regulation VCAM1 TNF 23789107 169879 Positive_regulation VCAM1 TNF 23789107 169880 Positive_regulation VCAM1 TNF 23789107 169881 Positive_regulation VCAM1 TNF 23789107 169910 Positive_regulation VCAM1 TNF 23789107 169911 Positive_regulation VCAM1 TNF 23789107 169912 Positive_regulation VCAM1 TNF 23789107 169923 Positive_regulation VCAM1 TNF 23789107 169924 Positive_regulation VCAM1 TNF 23789107 169936 Positive_regulation VCAM1 TNF 23789107 169937 Positive_regulation VCAM1 TNF 23789107 169946 Positive_regulation VCAM1 TNF 23789107 169947 Positive_regulation VCAM1 TNF 23884101 220653 Positive_regulation VCAM1 TNF 23884101 220654 Positive_regulation VCAM1 TNF 23895132 1726240 Positive_regulation VCAM1 TNF 23912327 2117649 Positive_regulation VCAM1 TNF 23924945 1109756 Positive_regulation VCAM1 TNF 23929007 87358 Positive_regulation VCAM1 TNF 23929007 87360 Positive_regulation VCAM1 TNF 23987139 412459 Positive_regulation VCAM1 TNF 23987139 412460 Positive_regulation VCAM1 TNF 23988189 732583 Positive_regulation VCAM1 TNF 24006483 1818011 Positive_regulation VCAM1 TNF 24039874 2844993 Positive_regulation VCAM1 TNF 24069252 2852292 Positive_regulation VCAM1 TNF 24069252 2852300 Positive_regulation VCAM1 TNF 24098720 2859477 Positive_regulation VCAM1 TNF 24106604 1764611 Positive_regulation VCAM1 TNF 24212934 499178 Positive_regulation VCAM1 TNF 24228622 359340 Positive_regulation VCAM1 TNF 24228622 359347 Positive_regulation VCAM1 TNF 24244812 204845 Positive_regulation VCAM1 TNF 24304882 1709586 Positive_regulation VCAM1 TNF 24311895 1755539 Positive_regulation VCAM1 TNF 24312436 2889325 Positive_regulation VCAM1 TNF 24327798 1755587 Positive_regulation VCAM1 TNF 24371453 824991 Positive_regulation VCAM1 TNF 24428883 510663 Positive_regulation VCAM1 TNF 24470523 1159237 Positive_regulation VCAM1 TNF 24470523 1159267 Positive_regulation VCAM1 TNF 24479486 1667590 Positive_regulation VCAM1 TNF 24502410 1618699 Positive_regulation VCAM1 TNF 24516119 1574952 Positive_regulation VCAM1 TNF 24516119 1574953 Positive_regulation VCAM1 TNF 24516119 1574954 Positive_regulation VCAM1 TNF 24516119 1574975 Positive_regulation VCAM1 TNF 24516119 1574976 Positive_regulation VCAM1 TNF 24516119 1575021 Positive_regulation VCAM1 TNF 24516119 1575022 Positive_regulation VCAM1 TNF 24516119 1575035 Positive_regulation VCAM1 TNF 24516119 1575036 Positive_regulation VCAM1 TNF 24563688 2924005 Positive_regulation VCAM1 TNF 24583847 1124487 Positive_regulation VCAM1 TNF 24612782 295940 Positive_regulation VCAM1 TNF 24614329 3140125 Positive_regulation VCAM1 TNF 24651155 3066386 Positive_regulation VCAM1 TNF 24659847 738368 Positive_regulation VCAM1 TNF 24707183 3177140 Positive_regulation VCAM1 TNF 24752205 2956456 Positive_regulation VCAM1 TNF 24752205 2956457 Positive_regulation VCAM1 TNF 24752205 2956460 Positive_regulation VCAM1 TNF 24752205 2956462 Positive_regulation VCAM1 TNF 24789665 1886437 Positive_regulation VCAM1 TNF 24817793 1758563 Positive_regulation VCAM1 TNF 24864133 1758811 Positive_regulation VCAM1 TNF 24891765 1759466 Positive_regulation VCAM1 TNF 24891765 1759495 Positive_regulation VCAM1 TNF 24899872 2252471 Positive_regulation VCAM1 TNF 24979620 2985653 Positive_regulation VCAM1 TNF 24979620 2985655 Positive_regulation VCAM1 TNF 25025040 194661 Positive_regulation VCAM1 TNF 25110549 2229770 Positive_regulation VCAM1 TNF 25152696 1628023 Positive_regulation VCAM1 TNF 25175315 1142659 Positive_regulation VCAM1 TNF 25214711 1762096 Positive_regulation VCAM1 TNF 25251368 3010089 Positive_regulation VCAM1 TNF 25251368 3010093 Positive_regulation VCAM1 TNF 25258478 1762467 Positive_regulation VCAM1 TNF 25352747 1917423 Positive_regulation VCAM1 TNF 25379003 1615516 Positive_regulation VCAM1 TNF 25435878 1074856 Positive_regulation VCAM1 TNF 25525444 827360 Positive_regulation VCAM1 TNF 25530974 1496794 Positive_regulation VCAM1 TNF 25576244 1736370 Positive_regulation VCAM1 TNF 7520473 1589468 Positive_regulation VCAM1 TNF 7528776 1589763 Positive_regulation VCAM1 TNF 7528776 1589764 Positive_regulation VCAM1 TNF 7530765 1590022 Positive_regulation VCAM1 TNF 7540655 1590369 Positive_regulation VCAM1 TNF 7593174 1437468 Positive_regulation VCAM1 TNF 7683689 1438795 Positive_regulation VCAM1 TNF 7686390 444174 Positive_regulation VCAM1 TNF 7705312 796398 Positive_regulation VCAM1 TNF 8340753 1594922 Positive_regulation VCAM1 TNF 8386742 1595094 Positive_regulation VCAM1 TNF 8691131 1598141 Positive_regulation VCAM1 TNF 8691131 1598215 Positive_regulation VCAM1 TNF 8691152 1598559 Positive_regulation VCAM1 TNF 8760826 1598979 Positive_regulation VCAM1 TNF 8760826 1598980 Positive_regulation VCAM1 TNF 9625761 1602963 Positive_regulation VCAM1 TNF 9625761 1602964 Positive_regulation VCAM1 TNF 9625761 1602965 Positive_regulation VCAM1 TNF 9625761 1602966 Positive_regulation VCAM1 TNF 9625761 1602967 Positive_regulation VCAM1 TNF 9625761 1602968 Positive_regulation VCAM1 TNF 9625761 1602973 Positive_regulation VCAM1 TNF 9625761 1602974 Positive_regulation VCAM1 TNF 9625761 1602981 Positive_regulation VCAM1 TNF 9625761 1602982 Positive_regulation VCAM1 TNF 9625761 1602983 Positive_regulation VCAM1 TNF 9832561 1472136 Positive_regulation VCAM1 TNF 9888481 448067 Positive_regulation VCAM1 TNF PMC4212304 3206310 Positive_regulation VCAN ADAMTS1 23405249 2752500 Positive_regulation VCAN CD14 11545252 1737862 Positive_regulation VCAN TNF 19087346 3109111 Positive_regulation VCAN TNF 22837669 1096345 Positive_regulation VCL CAPN8 7693714 1439062 Positive_regulation VCL SELL 7538138 1436710 Positive_regulation VCL TNS1 7593197 1437693 Positive_regulation VCP PGC 21475702 1238388 Positive_regulation VCP TNF 19193236 365525 Positive_regulation VDAC1 EPHB2 19847302 2429263 Positive_regulation VDAC2 EPHB2 19847302 2429264 Positive_regulation VDAC3 EPHB2 19847302 2429265 Positive_regulation VDR ARSA 15824083 1535489 Positive_regulation VDR CD14 10587349 1513460 Positive_regulation VDR CYP24A1 19787078 981266 Positive_regulation VDR CYP24A1 22537077 307539 Positive_regulation VDR CYP24A1 22984610 2689534 Positive_regulation VDR CYP24A1 23119081 2712703 Positive_regulation VDR CYP24A1 23119081 2712705 Positive_regulation VDR CYP24A1 23604122 2152038 Positive_regulation VDR CYP24A1 23604122 2152039 Positive_regulation VDR CYP24A1 24120915 1691548 Positive_regulation VDR FOXO1 23604122 2152040 Positive_regulation VDR IFI27 20808524 672535 Positive_regulation VDR TLR7 19503839 2418589 Positive_regulation VDR TLR7 19607716 325822 Positive_regulation VDR TLR7 20396414 1747361 Positive_regulation VDR TLR7 23589715 980646 Positive_regulation VDR TLR7 23710204 637478 Positive_regulation VDR TLR7 23875738 1700191 Positive_regulation VDR TLR7 24661536 290280 Positive_regulation VDR TLR7 24661536 290308 Positive_regulation VEGFA ADAMTS1 23289900 1867410 Positive_regulation VEGFA ADRB2 21517962 6679 Positive_regulation VEGFA ANGPT1 18835934 707038 Positive_regulation VEGFA ANGPT1 18835934 707041 Positive_regulation VEGFA ANGPT1 19435476 659193 Positive_regulation VEGFA ANGPT1 22558265 2624906 Positive_regulation VEGFA ANGPT1 23625964 2087337 Positive_regulation VEGFA CAPN8 22937084 2682871 Positive_regulation VEGFA CCND1 19851352 487440 Positive_regulation VEGFA CCND1 19851352 487443 Positive_regulation VEGFA CCND1 20459741 1855044 Positive_regulation VEGFA CHI3L1 23665676 2152238 Positive_regulation VEGFA CHI3L1 23755018 961354 Positive_regulation VEGFA CHI3L1 23755018 961411 Positive_regulation VEGFA CHI3L1 23755018 961414 Positive_regulation VEGFA CHI3L1 23755018 961421 Positive_regulation VEGFA CHI3L1 23840582 2815322 Positive_regulation VEGFA CHI3L1 24634660 964475 Positive_regulation VEGFA CHI3L1 24634660 964487 Positive_regulation VEGFA CHI3L1 24883044 484403 Positive_regulation VEGFA CTGF 11806848 3103645 Positive_regulation VEGFA CTGF 18628999 2392929 Positive_regulation VEGFA CTGF 22289291 450753 Positive_regulation VEGFA CTGF 22363445 2599074 Positive_regulation VEGFA CTGF 24451141 1123100 Positive_regulation VEGFA CTGF 25071162 1577104 Positive_regulation VEGFA CTGF 25237397 856981 Positive_regulation VEGFA CTGF 25237397 856997 Positive_regulation VEGFA EDN2 24763822 2958446 Positive_regulation VEGFA EDN2 24763822 2958449 Positive_regulation VEGFA EDN2 24763822 2958454 Positive_regulation VEGFA EDN2 24763822 2958456 Positive_regulation VEGFA EGLN3 20978507 436089 Positive_regulation VEGFA EPHB2 18159242 2381591 Positive_regulation VEGFA EPHB2 18391074 1351077 Positive_regulation VEGFA EPHB2 18391074 1351119 Positive_regulation VEGFA EPHB2 18852899 2397577 Positive_regulation VEGFA EPHB2 18852899 2397614 Positive_regulation VEGFA EPHB2 18852899 2397627 Positive_regulation VEGFA EPHB2 18852899 2397643 Positive_regulation VEGFA EPHB2 18852899 2397644 Positive_regulation VEGFA EPHB2 18852899 2397649 Positive_regulation VEGFA EPHB2 20700512 2458132 Positive_regulation VEGFA EPHB2 21625731 1161937 Positive_regulation VEGFA EPHB2 21672207 1229253 Positive_regulation VEGFA EPHB2 21828096 703018 Positive_regulation VEGFA EPHB2 23028886 2693507 Positive_regulation VEGFA EPHB2 23803732 543634 Positive_regulation VEGFA EPHB2 23922887 2827205 Positive_regulation VEGFA EPHB2 24216994 500822 Positive_regulation VEGFA EPHB2 24647208 2936054 Positive_regulation VEGFA EPHB2 24788652 2959204 Positive_regulation VEGFA EPHB2 25332857 3165815 Positive_regulation VEGFA F3 10864205 417150 Positive_regulation VEGFA F3 10901365 417251 Positive_regulation VEGFA F3 18293091 86797 Positive_regulation VEGFA FOXO1 22384192 2607226 Positive_regulation VEGFA FOXO1 22384192 2607227 Positive_regulation VEGFA FOXO1 22384192 2607236 Positive_regulation VEGFA FOXO1 22384192 2607240 Positive_regulation VEGFA FOXO1 22384192 2607247 Positive_regulation VEGFA GPNMB 20711474 2471261 Positive_regulation VEGFA GPR115 17726541 2377749 Positive_regulation VEGFA GPR115 24216979 500621 Positive_regulation VEGFA GPR132 17726541 2377738 Positive_regulation VEGFA GPR132 24216979 500610 Positive_regulation VEGFA GPR87 17726541 2377818 Positive_regulation VEGFA GPR87 24216979 500690 Positive_regulation VEGFA HBEGF 10188881 414121 Positive_regulation VEGFA HBEGF 25384035 3024620 Positive_regulation VEGFA HBEGF 25384035 3024629 Positive_regulation VEGFA HBEGF 25384035 3024635 Positive_regulation VEGFA ID1 16594992 274378 Positive_regulation VEGFA ID1 19014499 1503386 Positive_regulation VEGFA ID1 19951400 1006927 Positive_regulation VEGFA ID1 22139302 1879315 Positive_regulation VEGFA ID1 22139302 1879349 Positive_regulation VEGFA ID1 22139302 1879380 Positive_regulation VEGFA ID1 22139302 1879393 Positive_regulation VEGFA ID1 22139302 1879457 Positive_regulation VEGFA ID1 23617778 343341 Positive_regulation VEGFA ID1 23714001 1699836 Positive_regulation VEGFA IL1B 23935253 1754427 Positive_regulation VEGFA ITGAL 24955234 523146 Positive_regulation VEGFA JAG1 20016694 1160894 Positive_regulation VEGFA JAG1 23226563 2725479 Positive_regulation VEGFA MAP2K6 19812696 2428015 Positive_regulation VEGFA MAP2K6 21998580 3053743 Positive_regulation VEGFA MAP2K6 22069624 3182799 Positive_regulation VEGFA MAP2K6 24216994 500812 Positive_regulation VEGFA MAP2K6 25332857 3165807 Positive_regulation VEGFA MAP2K6 25332857 3165824 Positive_regulation VEGFA MIP 19936307 1910104 Positive_regulation VEGFA MIP 24069460 2853381 Positive_regulation VEGFA MMP28 19352513 2412373 Positive_regulation VEGFA MMP28 19375502 1731649 Positive_regulation VEGFA MMP28 21349159 3207086 Positive_regulation VEGFA MMP28 21535871 404701 Positive_regulation VEGFA MMP28 22044497 3165477 Positive_regulation VEGFA MMP28 22056617 13868 Positive_regulation VEGFA MMP28 22206448 6624 Positive_regulation VEGFA MMP28 23161900 91163 Positive_regulation VEGFA MMP28 24575750 248089 Positive_regulation VEGFA MMP28 24734023 964660 Positive_regulation VEGFA MMP28 25226613 2199994 Positive_regulation VEGFA MMP28 8554978 445094 Positive_regulation VEGFA MMP7 19352513 2412388 Positive_regulation VEGFA MMP7 21349159 3207101 Positive_regulation VEGFA MMP7 21535871 404716 Positive_regulation VEGFA MMP7 22044497 3165492 Positive_regulation VEGFA MMP7 22056617 13883 Positive_regulation VEGFA MMP7 22206448 6639 Positive_regulation VEGFA MMP7 23161900 91178 Positive_regulation VEGFA MMP7 24575750 248104 Positive_regulation VEGFA MMP7 24734023 964675 Positive_regulation VEGFA MMP7 25226613 2200009 Positive_regulation VEGFA MMP7 8554978 445110 Positive_regulation VEGFA NES 25206911 2006348 Positive_regulation VEGFA OSR1 25544921 515770 Positive_regulation VEGFA PDZK1 21653824 1791382 Positive_regulation VEGFA PECAM1 24959215 2168711 Positive_regulation VEGFA PGC 19696889 2310528 Positive_regulation VEGFA PGC 20214829 1504080 Positive_regulation VEGFA PGC 21437130 731289 Positive_regulation VEGFA PGC 21463529 3176066 Positive_regulation VEGFA PGC 25007941 1993421 Positive_regulation VEGFA PGC 25051364 2196792 Positive_regulation VEGFA PLAT 18182986 429799 Positive_regulation VEGFA PLAU 12556241 1843384 Positive_regulation VEGFA PLAU 18182986 429800 Positive_regulation VEGFA PLAU 9635853 447184 Positive_regulation VEGFA PTGER2 20219142 386005 Positive_regulation VEGFA PTGER2 22012553 494211 Positive_regulation VEGFA PTGER2 24156238 1726363 Positive_regulation VEGFA RCAN1 20625401 2454976 Positive_regulation VEGFA RCAN1 20625401 2454985 Positive_regulation VEGFA RCAN1 20625401 2455004 Positive_regulation VEGFA S100A7 17986321 250474 Positive_regulation VEGFA S100A7 23300877 2736950 Positive_regulation VEGFA S100A7 23618129 3226591 Positive_regulation VEGFA S100A7 23618129 3226599 Positive_regulation VEGFA S100A7 23618129 3226600 Positive_regulation VEGFA S100A7 23618129 3226605 Positive_regulation VEGFA SPHK1 25417698 1947396 Positive_regulation VEGFA TLR7 18404494 3089388 Positive_regulation VEGFA TLR7 20539755 2452357 Positive_regulation VEGFA TLR7 20539755 2452382 Positive_regulation VEGFA TLR7 20539755 2452406 Positive_regulation VEGFA TLR7 21998580 3053730 Positive_regulation VEGFA TLR7 25309919 201150 Positive_regulation VEGFA TNF 10682677 416249 Positive_regulation VEGFA TNF 12110126 99041 Positive_regulation VEGFA TNF 16091140 1624745 Positive_regulation VEGFA TNF 16091140 1624758 Positive_regulation VEGFA TNF 16236179 3096101 Positive_regulation VEGFA TNF 16622457 427500 Positive_regulation VEGFA TNF 16622457 427506 Positive_regulation VEGFA TNF 16803639 106171 Positive_regulation VEGFA TNF 17997858 109319 Positive_regulation VEGFA TNF 18202163 3177758 Positive_regulation VEGFA TNF 18947376 111696 Positive_regulation VEGFA TNF 19325820 1087883 Positive_regulation VEGFA TNF 20029652 178130 Positive_regulation VEGFA TNF 20126546 2439131 Positive_regulation VEGFA TNF 21614166 3525 Positive_regulation VEGFA TNF 21747731 1091435 Positive_regulation VEGFA TNF 21747731 1091436 Positive_regulation VEGFA TNF 21747731 1091443 Positive_regulation VEGFA TNF 21747731 1091449 Positive_regulation VEGFA TNF 21747731 1091450 Positive_regulation VEGFA TNF 21747731 1091453 Positive_regulation VEGFA TNF 21747731 1091455 Positive_regulation VEGFA TNF 21747731 1091456 Positive_regulation VEGFA TNF 21977033 1673210 Positive_regulation VEGFA TNF 21977033 1673211 Positive_regulation VEGFA TNF 22025890 1912988 Positive_regulation VEGFA TNF 22394384 1661318 Positive_regulation VEGFA TNF 23039130 266470 Positive_regulation VEGFA TNF 23150750 2225184 Positive_regulation VEGFA TNF 23150750 2225211 Positive_regulation VEGFA TNF 23202971 1098986 Positive_regulation VEGFA TNF 23213275 1915282 Positive_regulation VEGFA TNF 23285282 2733419 Positive_regulation VEGFA TNF 23573150 818510 Positive_regulation VEGFA TNF 23573150 818514 Positive_regulation VEGFA TNF 23662128 818806 Positive_regulation VEGFA TNF 23840095 1753413 Positive_regulation VEGFA TNF 23840095 1753418 Positive_regulation VEGFA TNF 23840095 1753421 Positive_regulation VEGFA TNF 23922887 2827194 Positive_regulation VEGFA TNF 23922887 2827195 Positive_regulation VEGFA TNF 23922887 2827196 Positive_regulation VEGFA TNF 23922887 2827199 Positive_regulation VEGFA TNF 23922887 2827200 Positive_regulation VEGFA TNF 23922887 2827202 Positive_regulation VEGFA TNF 23922887 2827203 Positive_regulation VEGFA TNF 23922887 2827219 Positive_regulation VEGFA TNF 24141333 88932 Positive_regulation VEGFA TNF 24204154 3177089 Positive_regulation VEGFA TNF 24286116 130149 Positive_regulation VEGFA TNF 24286133 130364 Positive_regulation VEGFA TNF 24289470 3227942 Positive_regulation VEGFA TNF 24312355 2888891 Positive_regulation VEGFA TNF 24312355 2888943 Positive_regulation VEGFA TNF 24734240 188950 Positive_regulation VEGFA TNF 24927773 3102546 Positive_regulation VEGFA TNF 24940033 1917049 Positive_regulation VEGFA TNF 24940033 1917050 Positive_regulation VEGFA TNF 24940033 1917088 Positive_regulation VEGFA TNF 24998927 807002 Positive_regulation VEGFA TNF 25116848 2118924 Positive_regulation VEGFA TNF 25125800 1760481 Positive_regulation VEGFA TNF 25152567 1761764 Positive_regulation VEGFA TNF 25332857 3165778 Positive_regulation VEGFA TNF 25332857 3165801 Positive_regulation VEGFA TNF 25384035 3024619 Positive_regulation VEGFA TNF 25533011 2119295 Positive_regulation VEGFA TNF 25594007 2173578 Positive_regulation VEGFA TNF 8601593 1450637 Positive_regulation VEGFA TNF PMC128906 99440 Positive_regulation VEGFA TNF PMC2833777 134321 Positive_regulation VEGFA TNFSF10 22194670 3152398 Positive_regulation VEGFA WFDC2 24389815 3139183 Positive_regulation VEGFC EPHB2 23424645 2755059 Positive_regulation VEGFC IL1B 23717664 2798663 Positive_regulation VEGFC IL1B 23717664 2798674 Positive_regulation VEGFC PPBP 20652010 1672285 Positive_regulation VEGFC TLR7 25580369 1490964 Positive_regulation VEGFC TNF 17997858 109320 Positive_regulation VEGFC TNF 17997858 109321 Positive_regulation VEGFC TNF 17997858 109323 Positive_regulation VEGFC TNF 17997858 109325 Positive_regulation VEGFC TNF 17997858 109357 Positive_regulation VEGFC TNF 17997858 109359 Positive_regulation VEGFC TNF 17997858 109360 Positive_regulation VEGFC TNF 20027220 2434778 Positive_regulation VEGFC TNF 23243599 2161897 Positive_regulation VEGFC TNF 25120672 2169279 Positive_regulation VEGFC TNF 25268699 3011561 Positive_regulation VGF MAP2K6 21151573 2485202 Positive_regulation VHL EGLN3 17986458 2031287 Positive_regulation VHL EGLN3 18402654 281373 Positive_regulation VIM CAPN8 18811945 226720 Positive_regulation VIM FOXQ1 25356753 2206494 Positive_regulation VIM ID1 24970809 2193985 Positive_regulation VIM ID1 25028095 1875764 Positive_regulation VIM KRT38 1710225 1334715 Positive_regulation VIM MYH16 19341503 1020516 Positive_regulation VIM MYH3 19341503 1020523 Positive_regulation VIM NEDD9 24058594 2848130 Positive_regulation VIM NEDD9 24058594 2848151 Positive_regulation VIM OLFM4 24495253 1482921 Positive_regulation VIM TNF 20003262 1655806 Positive_regulation VIM TNF 20003262 1655808 Positive_regulation VIM TNF 20003262 1655810 Positive_regulation VIM TNF 20691079 257052 Positive_regulation VIM TNF 21278075 3126175 Positive_regulation VIM WIF1 20573255 1856520 Positive_regulation VIMP TNF 19193236 365527 Positive_regulation VIP GPR115 20038525 1609538 Positive_regulation VIP GPR132 20038525 1609527 Positive_regulation VIP GPR87 20038525 1609607 Positive_regulation VIP NES 25093810 2995288 Positive_regulation VLDLR EPHB2 11266465 1269109 Positive_regulation VLDLR PCSK9 22848640 2669926 Positive_regulation VLDLR PCSK9 23883163 1726233 Positive_regulation VLDLR PCSK9 24252756 179021 Positive_regulation VLDLR PLAU 21047397 257828 Positive_regulation VPS28 NEDD9 23305486 3121270 Positive_regulation VPS37C NEDD9 23305486 3121274 Positive_regulation VSNL1 HTR1A 24465966 2912029 Positive_regulation VTI1A RAB31 20347926 833559 Positive_regulation VTN PLAU 18362935 430470 Positive_regulation VTN PLAU 22479587 2616192 Positive_regulation VTN PLAU 23843894 3177309 Positive_regulation VWF TNF 25422582 743482 Positive_regulation WARS TNF 21423713 2292331 Positive_regulation WASL EPHB2 19419567 525430 Positive_regulation WDR18 CD14 15494071 231139 Positive_regulation WDR18 TLR7 22888331 903224 Positive_regulation WDR61 ALOX5 8666909 1597097 Positive_regulation WDR61 F2R PMC2756345 496005 Positive_regulation WDR61 GPR115 21079759 3049750 Positive_regulation WDR61 GPR115 25375862 3023673 Positive_regulation WDR61 GPR132 21079759 3049739 Positive_regulation WDR61 GPR132 25375862 3023662 Positive_regulation WDR61 GPR87 21079759 3049819 Positive_regulation WDR61 GPR87 25375862 3023742 Positive_regulation WDR61 LPCAT1 21079759 3049447 Positive_regulation WDR61 LPCAT1 25415055 177550 Positive_regulation WDR61 TNF 18475680 1745378 Positive_regulation WDR61 TNF 18475682 1745391 Positive_regulation WDR61 TNF 18475742 1746300 Positive_regulation WDR61 TNF 21082032 2482400 Positive_regulation WDR61 TNF 2137857 1562738 Positive_regulation WDR61 TNF 2137857 1562751 Positive_regulation WDR61 TNF 21860543 1749389 Positive_regulation WDR61 TNF 2659725 1577677 Positive_regulation WDR61 TNF 3049910 1579738 Positive_regulation WDR61 TNF 3049910 1579739 Positive_regulation WDR61 TNF 3049910 1579740 Positive_regulation WDR61 TNF 3049910 1579741 Positive_regulation WDR61 TNF 3049910 1579779 Positive_regulation WDR61 TNF 3049910 1579789 Positive_regulation WDR61 TNF 3049910 1579799 Positive_regulation WDR61 TNF 3049910 1579804 Positive_regulation WDR61 TNF 3119758 1580133 Positive_regulation WDR61 TNF 3119758 1580134 Positive_regulation WDR61 TNF 3119758 1580135 Positive_regulation WDR61 TNF 3119758 1580136 Positive_regulation WDR61 TNF 3119758 1580137 Positive_regulation WDR61 TNF 3119758 1580171 Positive_regulation WDR61 TNF 7516414 1589277 Positive_regulation WDR61 TNF 7516414 1589282 Positive_regulation WDR61 TNF 7516414 1589302 Positive_regulation WDR61 TNF 7516414 1589307 Positive_regulation WEE1 NES 20083600 1370802 Positive_regulation WFDC2 EGF 24389815 3139185 Positive_regulation WFDC2 EGF 24389815 3139186 Positive_regulation WFDC2 INS 24389815 3139188 Positive_regulation WFDC2 IPO11 24975515 3143873 Positive_regulation WFDC2 IPO13 24975515 3143870 Positive_regulation WFDC2 IPO4 24975515 3143872 Positive_regulation WFDC2 IPO5 24975515 3143874 Positive_regulation WFDC2 IPO7 24975515 3143875 Positive_regulation WFDC2 IPO8 24975515 3143876 Positive_regulation WFDC2 IPO9 24975515 3143871 Positive_regulation WFDC2 VEGFA 24389815 3139184 Positive_regulation WFDC2 VEGFA 24389815 3139187 Positive_regulation WFDC2 VEGFA 24389815 3139190 Positive_regulation WIF1 CTNNB1 25286307 1131704 Positive_regulation WIF1 PDCD1 24632949 548657 Positive_regulation WIF1 PDCD10 24632949 548658 Positive_regulation WIF1 PDCD11 24632949 548656 Positive_regulation WIF1 PDCD2 24632949 548659 Positive_regulation WIF1 PDCD4 24632949 548660 Positive_regulation WIF1 PDCD5 24632949 548661 Positive_regulation WIF1 PDCD6 24632949 548662 Positive_regulation WIF1 PDCD7 24632949 548663 Positive_regulation WIF1 SFRP1 21083932 330496 Positive_regulation WIF1 SHH 24632949 548648 Positive_regulation WIF1 SHH 24632949 548649 Positive_regulation WIF1 SHH 24632949 548650 Positive_regulation WIF1 SHH 24632949 548679 Positive_regulation WNK1 CTGF 23227240 2725738 Positive_regulation WNK1 CTGF 23227240 2725755 Positive_regulation WNK1 EPHB2 20038977 1910345 Positive_regulation WNK1 ID1 19002171 431445 Positive_regulation WNK1 ID1 22139302 1879316 Positive_regulation WNK1 IL1B 24009751 2841602 Positive_regulation WNK1 JAG1 24970818 2194436 Positive_regulation WNK1 MAP2K6 23536830 2773097 Positive_regulation WNK1 SPHK1 20634980 2455740 Positive_regulation WNK1 TNF 11960552 276603 Positive_regulation WNK1 TNF 12003644 312734 Positive_regulation WNK1 TNF 14612916 423858 Positive_regulation WNK1 TNF 15175101 523520 Positive_regulation WNK1 TNF 15175101 523691 Positive_regulation WNK1 TNF 15694007 391920 Positive_regulation WNK1 TNF 19191868 806535 Positive_regulation WNK1 TNF 19448637 1960672 Positive_regulation WNK1 TNF 20204068 1213866 Positive_regulation WNK1 TNF 20205746 1656160 Positive_regulation WNK1 TNF 20577214 1985430 Positive_regulation WNK1 TNF 20693346 716056 Positive_regulation WNK1 TNF 20844082 1782658 Positive_regulation WNK1 TNF 21086176 1832181 Positive_regulation WNK1 TNF 21264230 2494873 Positive_regulation WNK1 TNF 21294864 121410 Positive_regulation WNK1 TNF 21483817 2512284 Positive_regulation WNK1 TNF 21572963 2520292 Positive_regulation WNK1 TNF 21573233 2523016 Positive_regulation WNK1 TNF 21736731 1898354 Positive_regulation WNK1 TNF 21765477 2141228 Positive_regulation WNK1 TNF 21765477 2141229 Positive_regulation WNK1 TNF 21765477 2141257 Positive_regulation WNK1 TNF 21765477 2141283 Positive_regulation WNK1 TNF 21857970 2544489 Positive_regulation WNK1 TNF 21904602 2550367 Positive_regulation WNK1 TNF 21904602 2550397 Positive_regulation WNK1 TNF 21904602 2550398 Positive_regulation WNK1 TNF 21904602 2550401 Positive_regulation WNK1 TNF 21912593 2552137 Positive_regulation WNK1 TNF 21912593 2552139 Positive_regulation WNK1 TNF 21912593 2552141 Positive_regulation WNK1 TNF 21915344 2553419 Positive_regulation WNK1 TNF 21966423 2557661 Positive_regulation WNK1 TNF 22076152 2570310 Positive_regulation WNK1 TNF 22076152 2570317 Positive_regulation WNK1 TNF 22076152 2570318 Positive_regulation WNK1 TNF 22110478 832161 Positive_regulation WNK1 TNF 22187158 2070775 Positive_regulation WNK1 TNF 22231395 14410 Positive_regulation WNK1 TNF 22426696 14543 Positive_regulation WNK1 TNF 22605974 1095615 Positive_regulation WNK1 TNF 22654408 2248280 Positive_regulation WNK1 TNF 22723832 2654743 Positive_regulation WNK1 TNF 22768286 2660442 Positive_regulation WNK1 TNF 22768286 2660450 Positive_regulation WNK1 TNF 22911724 2675981 Positive_regulation WNK1 TNF 23300567 2733834 Positive_regulation WNK1 TNF 23341882 2741321 Positive_regulation WNK1 TNF 23414442 1666066 Positive_regulation WNK1 TNF 23437404 2756808 Positive_regulation WNK1 TNF 23437404 2756912 Positive_regulation WNK1 TNF 23448136 245409 Positive_regulation WNK1 TNF 23536830 2773088 Positive_regulation WNK1 TNF 23555712 2774990 Positive_regulation WNK1 TNF 23573150 818517 Positive_regulation WNK1 TNF 23573150 818518 Positive_regulation WNK1 TNF 23577221 2225754 Positive_regulation WNK1 TNF 23593410 2781158 Positive_regulation WNK1 TNF 23593410 2781159 Positive_regulation WNK1 TNF 23593410 2781183 Positive_regulation WNK1 TNF 23593410 2781184 Positive_regulation WNK1 TNF 23593410 2781205 Positive_regulation WNK1 TNF 23603982 17458 Positive_regulation WNK1 TNF 23672297 96881 Positive_regulation WNK1 TNF 23690855 819193 Positive_regulation WNK1 TNF 23762160 820145 Positive_regulation WNK1 TNF 23861891 2820568 Positive_regulation WNK1 TNF 23935933 2828568 Positive_regulation WNK1 TNF 24066693 269791 Positive_regulation WNK1 TNF 24348668 3204764 Positive_regulation WNK1 TNF 24371075 1704451 Positive_regulation WNK1 TNF 24371453 824992 Positive_regulation WNK1 TNF 24386331 2903476 Positive_regulation WNK1 TNF 24386331 2903605 Positive_regulation WNK1 TNF 24498325 2919213 Positive_regulation WNK1 TNF 24498325 2919214 Positive_regulation WNK1 TNF 24502696 1233102 Positive_regulation WNK1 TNF 24502696 1233103 Positive_regulation WNK1 TNF 24502696 1233104 Positive_regulation WNK1 TNF 24502696 1233148 Positive_regulation WNK1 TNF 24502696 1233312 Positive_regulation WNK1 TNF 24530961 139371 Positive_regulation WNK1 TNF 24530961 139375 Positive_regulation WNK1 TNF 24552146 295851 Positive_regulation WNK1 TNF 24552146 295854 Positive_regulation WNK1 TNF 24580841 3169892 Positive_regulation WNK1 TNF 24586659 2926062 Positive_regulation WNK1 TNF 24587411 2929898 Positive_regulation WNK1 TNF 24614867 2933165 Positive_regulation WNK1 TNF 24669186 742930 Positive_regulation WNK1 TNF 24669186 742967 Positive_regulation WNK1 TNF 24800251 190151 Positive_regulation WNK1 TNF 24864134 1758826 Positive_regulation WNK1 TNF 24959724 2983184 Positive_regulation WNK1 TNF 25032222 194880 Positive_regulation WNK1 TNF 25045214 1760210 Positive_regulation WNK1 TNF 25114952 3156798 Positive_regulation WNK1 TNF 25114952 3156809 Positive_regulation WNK1 TNF 25121098 196517 Positive_regulation WNK1 TNF 25201625 541043 Positive_regulation WNK1 TNF 25201625 541054 Positive_regulation WNK1 TNF 25310191 3015017 Positive_regulation WNK1 TNF 25321472 578347 Positive_regulation WNK1 TNF 25420773 1947403 Positive_regulation WNK1 TNF 25489420 206817 Positive_regulation WNK1 TNF 25489420 206818 Positive_regulation WNK1 TNF 25489420 206819 Positive_regulation WNK1 TNF 25489420 206919 Positive_regulation WNK1 TNF 9625761 1602975 Positive_regulation WNK1 TNF PMC3647302 651827 Positive_regulation WNT1 ADAMTS1 23856044 128512 Positive_regulation WNT1 AXIN2 14551908 2255068 Positive_regulation WNT1 AXIN2 17389914 2375615 Positive_regulation WNT1 AXIN2 17710234 3071593 Positive_regulation WNT1 AXIN2 17961224 1645884 Positive_regulation WNT1 AXIN2 19909509 400629 Positive_regulation WNT1 AXIN2 20069066 1910495 Positive_regulation WNT1 AXIN2 21402791 1385767 Positive_regulation WNT1 AXIN2 21471006 1789857 Positive_regulation WNT1 AXIN2 21799911 2539133 Positive_regulation WNT1 AXIN2 22303459 2594508 Positive_regulation WNT1 AXIN2 22319467 929353 Positive_regulation WNT1 AXIN2 22319467 929486 Positive_regulation WNT1 AXIN2 22748080 1649019 Positive_regulation WNT1 AXIN2 22852817 265532 Positive_regulation WNT1 AXIN2 22957046 2685970 Positive_regulation WNT1 AXIN2 22957046 2685971 Positive_regulation WNT1 AXIN2 22957046 2685972 Positive_regulation WNT1 AXIN2 22957046 2685973 Positive_regulation WNT1 AXIN2 22957046 2686285 Positive_regulation WNT1 AXIN2 22957046 2686286 Positive_regulation WNT1 AXIN2 22957046 2686360 Positive_regulation WNT1 AXIN2 23275885 976475 Positive_regulation WNT1 AXIN2 23778311 1721523 Positive_regulation WNT1 AXIN2 24474204 3081447 Positive_regulation WNT1 AXIN2 24479426 131454 Positive_regulation WNT1 AXIN2 24594309 522639 Positive_regulation WNT1 AXIN2 24595031 2930479 Positive_regulation WNT1 AXIN2 24596510 657527 Positive_regulation WNT1 AXIN2 25013500 2169215 Positive_regulation WNT1 CCND1 21629692 2525515 Positive_regulation WNT1 CCND1 24999833 2986679 Positive_regulation WNT1 CHI3L1 23972995 608965 Positive_regulation WNT1 CHI3L1 23972995 608966 Positive_regulation WNT1 CTGF 24455745 186444 Positive_regulation WNT1 EPHB2 20727204 1858190 Positive_regulation WNT1 EPHB2 24103789 626357 Positive_regulation WNT1 EPHB2 24735639 1668053 Positive_regulation WNT1 FZD4 16602827 2260086 Positive_regulation WNT1 FZD4 16602827 2260222 Positive_regulation WNT1 FZD4 18215320 371523 Positive_regulation WNT1 FZD4 21668411 149208 Positive_regulation WNT1 FZD4 21668411 149357 Positive_regulation WNT1 FZD4 22645520 873693 Positive_regulation WNT1 FZD4 23259815 856354 Positive_regulation WNT1 FZD4 23401003 1402184 Positive_regulation WNT1 FZD4 23469146 2762270 Positive_regulation WNT1 FZD4 24132329 3137852 Positive_regulation WNT1 FZD4 24752542 3082031 Positive_regulation WNT1 FZD4 24860427 869355 Positive_regulation WNT1 FZD4 25374452 490079 Positive_regulation WNT1 HBEGF 22157721 1717815 Positive_regulation WNT1 JAG1 23560082 2776846 Positive_regulation WNT1 MMP7 20565841 3110689 Positive_regulation WNT1 MSX1 22383889 2331946 Positive_regulation WNT1 MSX1 23383281 2750026 Positive_regulation WNT1 MSX1 24550838 963770 Positive_regulation WNT1 MSX1 25048826 2990915 Positive_regulation WNT1 NEDD9 24058594 2848134 Positive_regulation WNT1 NES 25056574 475364 Positive_regulation WNT1 NES 25056574 475371 Positive_regulation WNT1 NRARP 20724159 3203255 Positive_regulation WNT1 NRARP 22187650 1145428 Positive_regulation WNT1 RGS2 23755177 2801729 Positive_regulation WNT1 RGS2 23755177 2801757 Positive_regulation WNT1 TNF 18511911 763684 Positive_regulation WNT1 TNF 18511911 763685 Positive_regulation WNT1 TNF 18511911 763686 Positive_regulation WNT1 TNF 18511911 763712 Positive_regulation WNT1 TNF 18511911 763713 Positive_regulation WNT1 TNF 24031147 3230642 Positive_regulation WNT1 TNF 24286133 130187 Positive_regulation WNT1 TNF 24286133 130188 Positive_regulation WNT1 TNF 24286133 130300 Positive_regulation WNT1 TNF 24286133 130301 Positive_regulation WNT1 TNF 24286133 130302 Positive_regulation WNT1 TNFSF10 20661477 2456794 Positive_regulation WNT1 WNT7A 19849863 254393 Positive_regulation WNT1 WNT7A 22745736 2656064 Positive_regulation WNT1 WNT7A 23818907 3174011 Positive_regulation WNT1 WNT7A 24287629 1939668 Positive_regulation WNT1 WNT7A 24711502 1418816 Positive_regulation WNT1 WNT7A 25170755 3003859 Positive_regulation WNT1 WNT7A 25170755 3003887 Positive_regulation WNT1 WNT7A 25170755 3003898 Positive_regulation WNT1 WNT7A 25170755 3003912 Positive_regulation WNT10A TNF 21203463 2490497 Positive_regulation WNT10B TNF 19351711 708247 Positive_regulation WNT11 ADAMTS1 23856044 128532 Positive_regulation WNT11 AXIN2 14551908 2255070 Positive_regulation WNT11 AXIN2 17389914 2375616 Positive_regulation WNT11 AXIN2 17710234 3071596 Positive_regulation WNT11 AXIN2 17961224 1645886 Positive_regulation WNT11 AXIN2 19909509 400631 Positive_regulation WNT11 AXIN2 20069066 1910498 Positive_regulation WNT11 AXIN2 21402791 1385770 Positive_regulation WNT11 AXIN2 21471006 1789859 Positive_regulation WNT11 AXIN2 21799911 2539135 Positive_regulation WNT11 AXIN2 22303459 2594511 Positive_regulation WNT11 AXIN2 22319467 929374 Positive_regulation WNT11 AXIN2 22319467 929489 Positive_regulation WNT11 AXIN2 22748080 1649021 Positive_regulation WNT11 AXIN2 22852817 265533 Positive_regulation WNT11 AXIN2 22957046 2685999 Positive_regulation WNT11 AXIN2 22957046 2686000 Positive_regulation WNT11 AXIN2 22957046 2686001 Positive_regulation WNT11 AXIN2 22957046 2686002 Positive_regulation WNT11 AXIN2 22957046 2686291 Positive_regulation WNT11 AXIN2 22957046 2686292 Positive_regulation WNT11 AXIN2 22957046 2686362 Positive_regulation WNT11 AXIN2 23275885 976478 Positive_regulation WNT11 AXIN2 23778311 1721526 Positive_regulation WNT11 AXIN2 24474204 3081449 Positive_regulation WNT11 AXIN2 24479426 131458 Positive_regulation WNT11 AXIN2 24594309 522647 Positive_regulation WNT11 AXIN2 24595031 2930480 Positive_regulation WNT11 AXIN2 24596510 657528 Positive_regulation WNT11 AXIN2 25013500 2169216 Positive_regulation WNT11 CCND1 21629692 2525517 Positive_regulation WNT11 CCND1 24999833 2986680 Positive_regulation WNT11 CHI3L1 23972995 608967 Positive_regulation WNT11 CHI3L1 23972995 608968 Positive_regulation WNT11 CTGF 24455745 186445 Positive_regulation WNT11 EPHB2 20727204 1858192 Positive_regulation WNT11 EPHB2 24103789 626362 Positive_regulation WNT11 EPHB2 24735639 1668054 Positive_regulation WNT11 FZD4 16602827 2260088 Positive_regulation WNT11 FZD4 16602827 2260225 Positive_regulation WNT11 FZD4 18215320 371535 Positive_regulation WNT11 FZD4 21668411 149218 Positive_regulation WNT11 FZD4 21668411 149360 Positive_regulation WNT11 FZD4 22645520 873716 Positive_regulation WNT11 FZD4 23259815 856364 Positive_regulation WNT11 FZD4 23401003 1402194 Positive_regulation WNT11 FZD4 23469146 2762290 Positive_regulation WNT11 FZD4 24132329 3137872 Positive_regulation WNT11 FZD4 24752542 3082041 Positive_regulation WNT11 FZD4 24860427 869365 Positive_regulation WNT11 FZD4 25374452 490081 Positive_regulation WNT11 HBEGF 22157721 1717817 Positive_regulation WNT11 JAG1 23560082 2776848 Positive_regulation WNT11 MMP7 20565841 3110690 Positive_regulation WNT11 MSX1 22383889 2331970 Positive_regulation WNT11 MSX1 23383281 2750029 Positive_regulation WNT11 MSX1 24550838 963775 Positive_regulation WNT11 MSX1 25048826 2990916 Positive_regulation WNT11 NEDD9 24058594 2848135 Positive_regulation WNT11 NES 25056574 475365 Positive_regulation WNT11 NES 25056574 475372 Positive_regulation WNT11 NRARP 20724159 3203256 Positive_regulation WNT11 NRARP 22187650 1145429 Positive_regulation WNT11 RGS2 23755177 2801731 Positive_regulation WNT11 RGS2 23755177 2801759 Positive_regulation WNT11 TNF 18511911 763688 Positive_regulation WNT11 TNF 18511911 763689 Positive_regulation WNT11 TNF 18511911 763690 Positive_regulation WNT11 TNF 18511911 763714 Positive_regulation WNT11 TNF 18511911 763715 Positive_regulation WNT11 TNF 24031147 3230643 Positive_regulation WNT11 TNF 24286133 130189 Positive_regulation WNT11 TNF 24286133 130190 Positive_regulation WNT11 TNF 24286133 130304 Positive_regulation WNT11 TNF 24286133 130305 Positive_regulation WNT11 TNF 24286133 130306 Positive_regulation WNT11 TNFSF10 20661477 2456796 Positive_regulation WNT11 WNT7A 19849863 254394 Positive_regulation WNT11 WNT7A 22745736 2656066 Positive_regulation WNT11 WNT7A 24287629 1939669 Positive_regulation WNT11 WNT7A 24711502 1418818 Positive_regulation WNT11 WNT7A 25170755 3003888 Positive_regulation WNT16 ADAMTS1 23856044 128667 Positive_regulation WNT16 AXIN2 14551908 2255080 Positive_regulation WNT16 AXIN2 17389914 2375621 Positive_regulation WNT16 AXIN2 17710234 3071611 Positive_regulation WNT16 AXIN2 17961224 1645896 Positive_regulation WNT16 AXIN2 19909509 400641 Positive_regulation WNT16 AXIN2 20069066 1910513 Positive_regulation WNT16 AXIN2 21402791 1385785 Positive_regulation WNT16 AXIN2 21471006 1789869 Positive_regulation WNT16 AXIN2 21799911 2539145 Positive_regulation WNT16 AXIN2 22303459 2594526 Positive_regulation WNT16 AXIN2 22319467 929479 Positive_regulation WNT16 AXIN2 22319467 929504 Positive_regulation WNT16 AXIN2 22748080 1649031 Positive_regulation WNT16 AXIN2 22852817 265538 Positive_regulation WNT16 AXIN2 22957046 2686144 Positive_regulation WNT16 AXIN2 22957046 2686145 Positive_regulation WNT16 AXIN2 22957046 2686146 Positive_regulation WNT16 AXIN2 22957046 2686147 Positive_regulation WNT16 AXIN2 22957046 2686321 Positive_regulation WNT16 AXIN2 22957046 2686322 Positive_regulation WNT16 AXIN2 22957046 2686372 Positive_regulation WNT16 AXIN2 23275885 976493 Positive_regulation WNT16 AXIN2 23778311 1721541 Positive_regulation WNT16 AXIN2 24474204 3081459 Positive_regulation WNT16 AXIN2 24479426 131488 Positive_regulation WNT16 AXIN2 24594309 522687 Positive_regulation WNT16 AXIN2 24595031 2930485 Positive_regulation WNT16 AXIN2 24596510 657533 Positive_regulation WNT16 AXIN2 25013500 2169221 Positive_regulation WNT16 CCND1 21629692 2525527 Positive_regulation WNT16 CCND1 24999833 2986692 Positive_regulation WNT16 CHI3L1 23972995 608977 Positive_regulation WNT16 CHI3L1 23972995 608978 Positive_regulation WNT16 CTGF 24455745 186450 Positive_regulation WNT16 EPHB2 20727204 1858202 Positive_regulation WNT16 EPHB2 24103789 626387 Positive_regulation WNT16 EPHB2 24735639 1668059 Positive_regulation WNT16 FZD4 16602827 2260099 Positive_regulation WNT16 FZD4 16602827 2260242 Positive_regulation WNT16 FZD4 18215320 371595 Positive_regulation WNT16 FZD4 21668411 149268 Positive_regulation WNT16 FZD4 21668411 149377 Positive_regulation WNT16 FZD4 22645520 873851 Positive_regulation WNT16 FZD4 23259815 856414 Positive_regulation WNT16 FZD4 23401003 1402244 Positive_regulation WNT16 FZD4 23469146 2762390 Positive_regulation WNT16 FZD4 24132329 3137979 Positive_regulation WNT16 FZD4 24752542 3082091 Positive_regulation WNT16 FZD4 24860427 869415 Positive_regulation WNT16 FZD4 25374452 490091 Positive_regulation WNT16 HBEGF 22157721 1717827 Positive_regulation WNT16 JAG1 23560082 2776858 Positive_regulation WNT16 MMP7 20565841 3110695 Positive_regulation WNT16 MSX1 22383889 2332090 Positive_regulation WNT16 MSX1 23383281 2750044 Positive_regulation WNT16 MSX1 24550838 963838 Positive_regulation WNT16 MSX1 25048826 2990921 Positive_regulation WNT16 NEDD9 24058594 2848140 Positive_regulation WNT16 NES 25056574 475370 Positive_regulation WNT16 NES 25056574 475377 Positive_regulation WNT16 NRARP 20724159 3203261 Positive_regulation WNT16 NRARP 22187650 1145434 Positive_regulation WNT16 RGS2 23755177 2801741 Positive_regulation WNT16 RGS2 23755177 2801769 Positive_regulation WNT16 TNF 18511911 763708 Positive_regulation WNT16 TNF 18511911 763709 Positive_regulation WNT16 TNF 18511911 763710 Positive_regulation WNT16 TNF 18511911 763724 Positive_regulation WNT16 TNF 18511911 763725 Positive_regulation WNT16 TNF 24031147 3230648 Positive_regulation WNT16 TNF 24286133 130199 Positive_regulation WNT16 TNF 24286133 130200 Positive_regulation WNT16 TNF 24286133 130324 Positive_regulation WNT16 TNF 24286133 130325 Positive_regulation WNT16 TNF 24286133 130326 Positive_regulation WNT16 TNFSF10 20661477 2456808 Positive_regulation WNT16 WNT7A 19849863 254399 Positive_regulation WNT16 WNT7A 22745736 2656076 Positive_regulation WNT16 WNT7A 24287629 1939675 Positive_regulation WNT16 WNT7A 24711502 1418828 Positive_regulation WNT16 WNT7A 25170755 3003895 Positive_regulation WNT2 ADAMTS1 23856044 128552 Positive_regulation WNT2 AXIN2 14551908 2255072 Positive_regulation WNT2 AXIN2 17389914 2375617 Positive_regulation WNT2 AXIN2 17710234 3071599 Positive_regulation WNT2 AXIN2 17961224 1645888 Positive_regulation WNT2 AXIN2 19909509 400633 Positive_regulation WNT2 AXIN2 20069066 1910501 Positive_regulation WNT2 AXIN2 21402791 1385773 Positive_regulation WNT2 AXIN2 21471006 1789861 Positive_regulation WNT2 AXIN2 21799911 2539137 Positive_regulation WNT2 AXIN2 22303459 2594514 Positive_regulation WNT2 AXIN2 22319467 929395 Positive_regulation WNT2 AXIN2 22319467 929492 Positive_regulation WNT2 AXIN2 22748080 1649023 Positive_regulation WNT2 AXIN2 22852817 265534 Positive_regulation WNT2 AXIN2 22957046 2686028 Positive_regulation WNT2 AXIN2 22957046 2686029 Positive_regulation WNT2 AXIN2 22957046 2686030 Positive_regulation WNT2 AXIN2 22957046 2686031 Positive_regulation WNT2 AXIN2 22957046 2686297 Positive_regulation WNT2 AXIN2 22957046 2686298 Positive_regulation WNT2 AXIN2 22957046 2686364 Positive_regulation WNT2 AXIN2 23275885 976481 Positive_regulation WNT2 AXIN2 23778311 1721529 Positive_regulation WNT2 AXIN2 24474204 3081451 Positive_regulation WNT2 AXIN2 24479426 131462 Positive_regulation WNT2 AXIN2 24594309 522655 Positive_regulation WNT2 AXIN2 24595031 2930481 Positive_regulation WNT2 AXIN2 24596510 657529 Positive_regulation WNT2 AXIN2 25013500 2169217 Positive_regulation WNT2 CCND1 21629692 2525519 Positive_regulation WNT2 CCND1 24999833 2986681 Positive_regulation WNT2 CHI3L1 23972995 608969 Positive_regulation WNT2 CHI3L1 23972995 608970 Positive_regulation WNT2 CTGF 24455745 186446 Positive_regulation WNT2 EPHB2 20727204 1858194 Positive_regulation WNT2 EPHB2 24103789 626367 Positive_regulation WNT2 EPHB2 24735639 1668055 Positive_regulation WNT2 FZD4 16602827 2260090 Positive_regulation WNT2 FZD4 16602827 2260228 Positive_regulation WNT2 FZD4 18215320 371547 Positive_regulation WNT2 FZD4 21668411 149228 Positive_regulation WNT2 FZD4 21668411 149363 Positive_regulation WNT2 FZD4 22645520 873739 Positive_regulation WNT2 FZD4 23259815 856374 Positive_regulation WNT2 FZD4 23401003 1402204 Positive_regulation WNT2 FZD4 23469146 2762310 Positive_regulation WNT2 FZD4 24132329 3137892 Positive_regulation WNT2 FZD4 24752542 3082051 Positive_regulation WNT2 FZD4 24860427 869375 Positive_regulation WNT2 FZD4 25374452 490083 Positive_regulation WNT2 HBEGF 22157721 1717819 Positive_regulation WNT2 ID1 21068842 1986654 Positive_regulation WNT2 JAG1 23560082 2776850 Positive_regulation WNT2 MMP7 20565841 3110691 Positive_regulation WNT2 MSX1 22383889 2331994 Positive_regulation WNT2 MSX1 23383281 2750032 Positive_regulation WNT2 MSX1 23383281 2750060 Positive_regulation WNT2 MSX1 24550838 963780 Positive_regulation WNT2 MSX1 25048826 2990917 Positive_regulation WNT2 NEDD9 24058594 2848136 Positive_regulation WNT2 NES 25056574 475366 Positive_regulation WNT2 NES 25056574 475373 Positive_regulation WNT2 NRARP 20724159 3203257 Positive_regulation WNT2 NRARP 22187650 1145430 Positive_regulation WNT2 RGS2 23755177 2801733 Positive_regulation WNT2 RGS2 23755177 2801761 Positive_regulation WNT2 TNF 18511911 763692 Positive_regulation WNT2 TNF 18511911 763693 Positive_regulation WNT2 TNF 18511911 763694 Positive_regulation WNT2 TNF 18511911 763716 Positive_regulation WNT2 TNF 18511911 763717 Positive_regulation WNT2 TNF 24031147 3230644 Positive_regulation WNT2 TNF 24286133 130191 Positive_regulation WNT2 TNF 24286133 130192 Positive_regulation WNT2 TNF 24286133 130308 Positive_regulation WNT2 TNF 24286133 130309 Positive_regulation WNT2 TNF 24286133 130310 Positive_regulation WNT2 TNFSF10 20661477 2456798 Positive_regulation WNT2 WNT7A 19849863 254395 Positive_regulation WNT2 WNT7A 22745736 2656068 Positive_regulation WNT2 WNT7A 24287629 1939670 Positive_regulation WNT2 WNT7A 24711502 1418820 Positive_regulation WNT2 WNT7A 25170755 3003889 Positive_regulation WNT3 ADAMTS1 23856044 128572 Positive_regulation WNT3 AXIN2 14551908 2255074 Positive_regulation WNT3 AXIN2 17389914 2375618 Positive_regulation WNT3 AXIN2 17710234 3071602 Positive_regulation WNT3 AXIN2 17961224 1645890 Positive_regulation WNT3 AXIN2 19909509 400635 Positive_regulation WNT3 AXIN2 20069066 1910504 Positive_regulation WNT3 AXIN2 21402791 1385776 Positive_regulation WNT3 AXIN2 21471006 1789863 Positive_regulation WNT3 AXIN2 21799911 2539139 Positive_regulation WNT3 AXIN2 22303459 2594517 Positive_regulation WNT3 AXIN2 22319467 929416 Positive_regulation WNT3 AXIN2 22319467 929495 Positive_regulation WNT3 AXIN2 22748080 1649025 Positive_regulation WNT3 AXIN2 22852817 265535 Positive_regulation WNT3 AXIN2 22957046 2686057 Positive_regulation WNT3 AXIN2 22957046 2686058 Positive_regulation WNT3 AXIN2 22957046 2686059 Positive_regulation WNT3 AXIN2 22957046 2686060 Positive_regulation WNT3 AXIN2 22957046 2686303 Positive_regulation WNT3 AXIN2 22957046 2686304 Positive_regulation WNT3 AXIN2 22957046 2686366 Positive_regulation WNT3 AXIN2 23275885 976484 Positive_regulation WNT3 AXIN2 23778311 1721532 Positive_regulation WNT3 AXIN2 24474204 3081453 Positive_regulation WNT3 AXIN2 24479426 131466 Positive_regulation WNT3 AXIN2 24594309 522663 Positive_regulation WNT3 AXIN2 24595031 2930482 Positive_regulation WNT3 AXIN2 24596510 657530 Positive_regulation WNT3 AXIN2 25013500 2169218 Positive_regulation WNT3 CCND1 21629692 2525521 Positive_regulation WNT3 CCND1 24999833 2986682 Positive_regulation WNT3 CHI3L1 23972995 608971 Positive_regulation WNT3 CHI3L1 23972995 608972 Positive_regulation WNT3 CTGF 24455745 186447 Positive_regulation WNT3 EPHB2 20727204 1858196 Positive_regulation WNT3 EPHB2 24103789 626372 Positive_regulation WNT3 EPHB2 24735639 1668056 Positive_regulation WNT3 FZD4 16602827 2260092 Positive_regulation WNT3 FZD4 16602827 2260231 Positive_regulation WNT3 FZD4 18215320 371559 Positive_regulation WNT3 FZD4 21668411 149238 Positive_regulation WNT3 FZD4 21668411 149366 Positive_regulation WNT3 FZD4 22645520 873762 Positive_regulation WNT3 FZD4 23259815 856384 Positive_regulation WNT3 FZD4 23401003 1402214 Positive_regulation WNT3 FZD4 23469146 2762330 Positive_regulation WNT3 FZD4 24132329 3137912 Positive_regulation WNT3 FZD4 24752542 3082061 Positive_regulation WNT3 FZD4 24860427 869385 Positive_regulation WNT3 FZD4 25374452 490085 Positive_regulation WNT3 HBEGF 22157721 1717821 Positive_regulation WNT3 JAG1 23560082 2776852 Positive_regulation WNT3 MMP7 20565841 3110692 Positive_regulation WNT3 MSX1 22383889 2332018 Positive_regulation WNT3 MSX1 23383281 2750035 Positive_regulation WNT3 MSX1 24550838 963785 Positive_regulation WNT3 MSX1 25048826 2990918 Positive_regulation WNT3 NEDD9 24058594 2848137 Positive_regulation WNT3 NES 25056574 475367 Positive_regulation WNT3 NES 25056574 475374 Positive_regulation WNT3 NRARP 20724159 3203258 Positive_regulation WNT3 NRARP 22187650 1145431 Positive_regulation WNT3 RGS2 23755177 2801735 Positive_regulation WNT3 RGS2 23755177 2801763 Positive_regulation WNT3 TNF 18511911 763696 Positive_regulation WNT3 TNF 18511911 763697 Positive_regulation WNT3 TNF 18511911 763698 Positive_regulation WNT3 TNF 18511911 763718 Positive_regulation WNT3 TNF 18511911 763719 Positive_regulation WNT3 TNF 24031147 3230645 Positive_regulation WNT3 TNF 24286133 130193 Positive_regulation WNT3 TNF 24286133 130194 Positive_regulation WNT3 TNF 24286133 130312 Positive_regulation WNT3 TNF 24286133 130313 Positive_regulation WNT3 TNF 24286133 130314 Positive_regulation WNT3 TNFSF10 20661477 2456800 Positive_regulation WNT3 WNT7A 19849863 254396 Positive_regulation WNT3 WNT7A 22745736 2656070 Positive_regulation WNT3 WNT7A 24287629 1939671 Positive_regulation WNT3 WNT7A 24711502 1418822 Positive_regulation WNT3 WNT7A 25170755 3003890 Positive_regulation WNT3A AXIN2 17984306 1547640 Positive_regulation WNT3A AXIN2 21536751 1386700 Positive_regulation WNT3A AXIN2 24130821 2867157 Positive_regulation WNT3A CCND1 18452624 1646336 Positive_regulation WNT3A MYH16 23497616 3161504 Positive_regulation WNT3A MYH3 23497616 3161511 Positive_regulation WNT3A NES 22132182 2574312 Positive_regulation WNT3A WNT7A 25170755 3003860 Positive_regulation WNT4 ADAMTS1 23856044 128592 Positive_regulation WNT4 AXIN2 14551908 2255076 Positive_regulation WNT4 AXIN2 17389914 2375619 Positive_regulation WNT4 AXIN2 17710234 3071605 Positive_regulation WNT4 AXIN2 17961224 1645892 Positive_regulation WNT4 AXIN2 19909509 400637 Positive_regulation WNT4 AXIN2 20069066 1910507 Positive_regulation WNT4 AXIN2 21402791 1385779 Positive_regulation WNT4 AXIN2 21471006 1789865 Positive_regulation WNT4 AXIN2 21799911 2539141 Positive_regulation WNT4 AXIN2 22303459 2594520 Positive_regulation WNT4 AXIN2 22319467 929437 Positive_regulation WNT4 AXIN2 22319467 929498 Positive_regulation WNT4 AXIN2 22748080 1649027 Positive_regulation WNT4 AXIN2 22852817 265536 Positive_regulation WNT4 AXIN2 22957046 2686086 Positive_regulation WNT4 AXIN2 22957046 2686087 Positive_regulation WNT4 AXIN2 22957046 2686088 Positive_regulation WNT4 AXIN2 22957046 2686089 Positive_regulation WNT4 AXIN2 22957046 2686309 Positive_regulation WNT4 AXIN2 22957046 2686310 Positive_regulation WNT4 AXIN2 22957046 2686368 Positive_regulation WNT4 AXIN2 23275885 976487 Positive_regulation WNT4 AXIN2 23778311 1721535 Positive_regulation WNT4 AXIN2 24474204 3081455 Positive_regulation WNT4 AXIN2 24479426 131470 Positive_regulation WNT4 AXIN2 24594309 522671 Positive_regulation WNT4 AXIN2 24595031 2930483 Positive_regulation WNT4 AXIN2 24596510 657531 Positive_regulation WNT4 AXIN2 25013500 2169219 Positive_regulation WNT4 CCND1 21629692 2525523 Positive_regulation WNT4 CCND1 24999833 2986683 Positive_regulation WNT4 CHI3L1 23972995 608973 Positive_regulation WNT4 CHI3L1 23972995 608974 Positive_regulation WNT4 CTGF 24455745 186448 Positive_regulation WNT4 EPHB2 20727204 1858198 Positive_regulation WNT4 EPHB2 24103789 626377 Positive_regulation WNT4 EPHB2 24735639 1668057 Positive_regulation WNT4 FZD4 16602827 2260094 Positive_regulation WNT4 FZD4 16602827 2260234 Positive_regulation WNT4 FZD4 18215320 371571 Positive_regulation WNT4 FZD4 21668411 149248 Positive_regulation WNT4 FZD4 21668411 149369 Positive_regulation WNT4 FZD4 22645520 873785 Positive_regulation WNT4 FZD4 23259815 856394 Positive_regulation WNT4 FZD4 23401003 1402224 Positive_regulation WNT4 FZD4 23469146 2762350 Positive_regulation WNT4 FZD4 24132329 3137932 Positive_regulation WNT4 FZD4 24752542 3082071 Positive_regulation WNT4 FZD4 24860427 869395 Positive_regulation WNT4 FZD4 25374452 490087 Positive_regulation WNT4 HBEGF 22157721 1717823 Positive_regulation WNT4 JAG1 23560082 2776636 Positive_regulation WNT4 JAG1 23560082 2776854 Positive_regulation WNT4 JAG1 23560082 2776903 Positive_regulation WNT4 MMP7 20565841 3110693 Positive_regulation WNT4 MSX1 22383889 2332042 Positive_regulation WNT4 MSX1 23383281 2750038 Positive_regulation WNT4 MSX1 24550838 963790 Positive_regulation WNT4 MSX1 25048826 2990919 Positive_regulation WNT4 NEDD9 24058594 2848138 Positive_regulation WNT4 NES 25056574 475368 Positive_regulation WNT4 NES 25056574 475375 Positive_regulation WNT4 NRARP 20724159 3203259 Positive_regulation WNT4 NRARP 22187650 1145432 Positive_regulation WNT4 RGS2 23755177 2801737 Positive_regulation WNT4 RGS2 23755177 2801765 Positive_regulation WNT4 TNF 18511911 763700 Positive_regulation WNT4 TNF 18511911 763701 Positive_regulation WNT4 TNF 18511911 763702 Positive_regulation WNT4 TNF 18511911 763720 Positive_regulation WNT4 TNF 18511911 763721 Positive_regulation WNT4 TNF 24031147 3230646 Positive_regulation WNT4 TNF 24286133 130195 Positive_regulation WNT4 TNF 24286133 130196 Positive_regulation WNT4 TNF 24286133 130316 Positive_regulation WNT4 TNF 24286133 130317 Positive_regulation WNT4 TNF 24286133 130318 Positive_regulation WNT4 TNFSF10 20661477 2456802 Positive_regulation WNT4 WNT7A 19849863 254397 Positive_regulation WNT4 WNT7A 22745736 2656072 Positive_regulation WNT4 WNT7A 24287629 1939672 Positive_regulation WNT4 WNT7A 24711502 1418824 Positive_regulation WNT4 WNT7A 25170755 3003891 Positive_regulation WNT5A FZD4 10893270 1260577 Positive_regulation WNT5A FZD4 16602827 2260051 Positive_regulation WNT5A FZD4 16602827 2260236 Positive_regulation WNT5A FZD4 21668411 149371 Positive_regulation WNT5A MMP28 23484019 2765069 Positive_regulation WNT5A MMP7 23484019 2765084 Positive_regulation WNT5A TLR7 18442421 1043620 Positive_regulation WNT5A TLR7 22485170 2616887 Positive_regulation WNT5A TLR7 23892477 3136527 Positive_regulation WNT5A TNF 24592264 911248 Positive_regulation WNT5B MAP2K6 21418646 305028 Positive_regulation WNT6 ADAMTS1 23856044 128612 Positive_regulation WNT6 AXIN2 14551908 2255078 Positive_regulation WNT6 AXIN2 17389914 2375620 Positive_regulation WNT6 AXIN2 17710234 3071608 Positive_regulation WNT6 AXIN2 17961224 1645894 Positive_regulation WNT6 AXIN2 19909509 400639 Positive_regulation WNT6 AXIN2 20069066 1910510 Positive_regulation WNT6 AXIN2 21402791 1385782 Positive_regulation WNT6 AXIN2 21471006 1789867 Positive_regulation WNT6 AXIN2 21799911 2539143 Positive_regulation WNT6 AXIN2 22303459 2594523 Positive_regulation WNT6 AXIN2 22319467 929458 Positive_regulation WNT6 AXIN2 22319467 929501 Positive_regulation WNT6 AXIN2 22748080 1649029 Positive_regulation WNT6 AXIN2 22852817 265537 Positive_regulation WNT6 AXIN2 22957046 2686115 Positive_regulation WNT6 AXIN2 22957046 2686116 Positive_regulation WNT6 AXIN2 22957046 2686117 Positive_regulation WNT6 AXIN2 22957046 2686118 Positive_regulation WNT6 AXIN2 22957046 2686315 Positive_regulation WNT6 AXIN2 22957046 2686316 Positive_regulation WNT6 AXIN2 22957046 2686370 Positive_regulation WNT6 AXIN2 23275885 976490 Positive_regulation WNT6 AXIN2 23778311 1721538 Positive_regulation WNT6 AXIN2 24474204 3081457 Positive_regulation WNT6 AXIN2 24479426 131474 Positive_regulation WNT6 AXIN2 24594309 522679 Positive_regulation WNT6 AXIN2 24595031 2930484 Positive_regulation WNT6 AXIN2 24596510 657532 Positive_regulation WNT6 AXIN2 25013500 2169220 Positive_regulation WNT6 CCND1 21629692 2525525 Positive_regulation WNT6 CCND1 24999833 2986684 Positive_regulation WNT6 CHI3L1 23972995 608975 Positive_regulation WNT6 CHI3L1 23972995 608976 Positive_regulation WNT6 CTGF 24455745 186449 Positive_regulation WNT6 EPHB2 20727204 1858200 Positive_regulation WNT6 EPHB2 24103789 626382 Positive_regulation WNT6 EPHB2 24735639 1668058 Positive_regulation WNT6 FZD4 16602827 2260097 Positive_regulation WNT6 FZD4 16602827 2260239 Positive_regulation WNT6 FZD4 18215320 371583 Positive_regulation WNT6 FZD4 21668411 149258 Positive_regulation WNT6 FZD4 21668411 149374 Positive_regulation WNT6 FZD4 22645520 873808 Positive_regulation WNT6 FZD4 23259815 856404 Positive_regulation WNT6 FZD4 23401003 1402234 Positive_regulation WNT6 FZD4 23469146 2762370 Positive_regulation WNT6 FZD4 24132329 3137952 Positive_regulation WNT6 FZD4 24752542 3082081 Positive_regulation WNT6 FZD4 24860427 869405 Positive_regulation WNT6 FZD4 25374452 490089 Positive_regulation WNT6 HBEGF 22157721 1717825 Positive_regulation WNT6 JAG1 23560082 2776856 Positive_regulation WNT6 MMP7 20565841 3110694 Positive_regulation WNT6 MSX1 22383889 2332066 Positive_regulation WNT6 MSX1 23383281 2750041 Positive_regulation WNT6 MSX1 24550838 963795 Positive_regulation WNT6 MSX1 25048826 2990920 Positive_regulation WNT6 NEDD9 24058594 2848139 Positive_regulation WNT6 NES 25056574 475369 Positive_regulation WNT6 NES 25056574 475376 Positive_regulation WNT6 NRARP 20724159 3203260 Positive_regulation WNT6 NRARP 22187650 1145433 Positive_regulation WNT6 RGS2 23755177 2801739 Positive_regulation WNT6 RGS2 23755177 2801767 Positive_regulation WNT6 TNF 18511911 763704 Positive_regulation WNT6 TNF 18511911 763705 Positive_regulation WNT6 TNF 18511911 763706 Positive_regulation WNT6 TNF 18511911 763722 Positive_regulation WNT6 TNF 18511911 763723 Positive_regulation WNT6 TNF 24031147 3230647 Positive_regulation WNT6 TNF 24286133 130197 Positive_regulation WNT6 TNF 24286133 130198 Positive_regulation WNT6 TNF 24286133 130320 Positive_regulation WNT6 TNF 24286133 130321 Positive_regulation WNT6 TNF 24286133 130322 Positive_regulation WNT6 TNFSF10 20661477 2456804 Positive_regulation WNT6 WNT7A 19849863 254398 Positive_regulation WNT6 WNT7A 22745736 2656074 Positive_regulation WNT6 WNT7A 24287629 1939673 Positive_regulation WNT6 WNT7A 24711502 1418826 Positive_regulation WNT6 WNT7A 25170755 3003892 Positive_regulation WNT7A AKT1 24287629 1939707 Positive_regulation WNT7A AKT2 24287629 1939708 Positive_regulation WNT7A AKT3 24287629 1939709 Positive_regulation WNT7A APC 12716446 99635 Positive_regulation WNT7A APC 18652670 1891074 Positive_regulation WNT7A BSN 25170755 3003893 Positive_regulation WNT7A CD46 24403870 685002 Positive_regulation WNT7A DES 16759992 792665 Positive_regulation WNT7A DNMT3A 22403725 2609246 Positive_regulation WNT7A FN1 23630617 2785305 Positive_regulation WNT7A FZD10 23304155 2119885 Positive_regulation WNT7A FZD5 23437169 2755891 Positive_regulation WNT7A FZD5 24065916 973388 Positive_regulation WNT7A FZD7 24287629 1939674 Positive_regulation WNT7A FZD9 23815780 269066 Positive_regulation WNT7A GRHL2 23284647 2730358 Positive_regulation WNT7A GRHL2 23284647 2730372 Positive_regulation WNT7A IGF2 23213437 168792 Positive_regulation WNT7A IL1A 23965253 129062 Positive_regulation WNT7A IL1A 24479426 131597 Positive_regulation WNT7A IL1A 24479426 131631 Positive_regulation WNT7A MAP2 25170755 3003881 Positive_regulation WNT7A MYLIP 23862015 169980 Positive_regulation WNT7A MYLIP 23862015 170024 Positive_regulation WNT7A MYLIP 23862015 170052 Positive_regulation WNT7A NR2E1 23377854 2008719 Positive_regulation WNT7A NTS 25170755 3003902 Positive_regulation WNT7A OXA1L 23862015 169981 Positive_regulation WNT7A OXA1L 23862015 170025 Positive_regulation WNT7A OXA1L 23862015 170053 Positive_regulation WNT7A PRH1 18498250 145885 Positive_regulation WNT7A PRH2 18498250 145886 Positive_regulation WNT7A SHH 23140504 1997935 Positive_regulation WNT7A SPRY4 24744103 494518 Positive_regulation WNT7A SYN1 25170755 3003880 Positive_regulation WNT7A SYN1 25170755 3003894 Positive_regulation WNT7A VANGL2 22179044 1928033 Positive_regulation WNT7A WNT1 22619564 3128935 Positive_regulation WNT7A WNT1 25170755 3003901 Positive_regulation WNT7A WNT1 25170755 3003913 Positive_regulation WNT7A WNT10A 21970630 1648652 Positive_regulation WNT7A WNT3A 21970630 1648653 Positive_regulation WNT7A WNT4 22619564 3128936 Positive_regulation WNT7A WNT5A 21970630 1648651 Positive_regulation WNT7A WNT5A 22619564 3128937 Positive_regulation WNT7A WNT6 22619564 3128938 Positive_regulation WNT7B MSX1 23383281 2750062 Positive_regulation WNT8A MAP2K6 21418646 305021 Positive_regulation WSN TNF 23226456 2725082 Positive_regulation WT1 PODXL 25485314 579621 Positive_regulation WTS F2R 23940457 2283789 Positive_regulation WWOX MAP2K6 23459853 942390 Positive_regulation WWOX TNF 11960552 276600 Positive_regulation WWOX TNF 11960552 276609 Positive_regulation WWOX TNF 11960552 276630 Positive_regulation WWOX TNF 11960552 276632 Positive_regulation WWOX TNF 17567906 370617 Positive_regulation XBP1 EPHB2 23277279 610862 Positive_regulation XBP1 FOXO1 23277279 610807 Positive_regulation XBP1 FOXO1 23277279 610924 Positive_regulation XBP1 FOXO1 24710528 619123 Positive_regulation XBP1 FOXO1 25216759 1896294 Positive_regulation XBP1 TLR7 20513765 1376530 Positive_regulation XBP1 TLR7 25120559 896714 Positive_regulation XBP1 TNF PMC4212306 3206463 Positive_regulation XBP1 TNFSF10 22613960 1140855 Positive_regulation XBP1 TNFSF10 22613960 1140865 Positive_regulation XCL1 MIP 20544034 2452618 Positive_regulation XCL1 TNF 20544034 2452615 Positive_regulation XDH TNF 21912722 2223917 Positive_regulation XDH TNF 23300968 2737748 Positive_regulation XIAP CAPN8 25216527 2199890 Positive_regulation XIAP GLP1R 19720788 710995 Positive_regulation XIAP MAP2K6 23056924 140498 Positive_regulation XIAP MMP28 24336521 1820000 Positive_regulation XIAP MMP7 24336521 1820016 Positive_regulation XIAP TNF 12967350 3095099 Positive_regulation XIAP TNFSF10 20661217 2133125 Positive_regulation XIAP TNFSF10 23703388 561937 Positive_regulation XIST CDKN1C 24979243 1942953 Positive_regulation XPO1 IFI27 23029392 2697152 Positive_regulation XPO1 NES 10330396 1246066 Positive_regulation XPO1 NES 11149926 1267021 Positive_regulation XPO1 NES 11149926 1267024 Positive_regulation XPO1 NES 11425870 1271799 Positive_regulation XPO1 NES 21811608 2539716 Positive_regulation XPO1 NES 22973269 925217 Positive_regulation XPO1 NES 23825024 1816870 Positive_regulation XPO1 NES 23984714 3215877 Positive_regulation XPO1 NES 25119991 2997191 Positive_regulation XRCC5 EPHB2 23758320 151602 Positive_regulation XRCC5 PECAM1 10725328 1256528 Positive_regulation XRCC5 PECAM1 10725328 1256550 Positive_regulation XRCC5 TNF 16043520 1536939 Positive_regulation XRCC5 TNFSF10 20205745 375346 Positive_regulation XRCC6 CLU 24156019 492147 Positive_regulation XRCC6 EPHB2 23758320 151626 Positive_regulation XRCC6 PECAM1 10725328 1256534 Positive_regulation XRCC6 PECAM1 10725328 1256553 Positive_regulation XRCC6 TNF 16043520 1536942 Positive_regulation XRCC6 TNFSF10 20205745 375347 Positive_regulation XRN1 RNASE1 25200086 2104752 Positive_regulation XRN1 RNASE7 25200086 2104760 Positive_regulation XRN2 RNASE1 25200086 2104680 Positive_regulation XRN2 RNASE7 25200086 2104688 Positive_regulation YAP1 EPHB2 23857250 2156937 Positive_regulation YAP1 ITGB2 23857250 2156960 Positive_regulation YAP1 MAP2K6 23857250 2156943 Positive_regulation YBX1 CLU 24770864 2189491 Positive_regulation YBX1 CLU 25503391 1947704 Positive_regulation YBX1 EPHB2 21170361 2320450 Positive_regulation YBX1 EPHB2 22523682 1688019 Positive_regulation YBX1 EPHB2 23967153 2834697 Positive_regulation YBX1 EPHB2 23967153 2834729 Positive_regulation YBX1 FAS 11516336 994104 Positive_regulation YBX1 MAP2K6 21170361 2320461 Positive_regulation YBX1 MAP2K6 21170361 2320462 Positive_regulation YBX1 MAP2K6 21392397 467294 Positive_regulation YBX1 RNASE1 22730292 2078968 Positive_regulation YBX3 MAP2K6 21368869 550788 Positive_regulation YBX3 MAP2K6 21368869 550807 Positive_regulation YME1L1 TLR7 21483755 2323130 Positive_regulation YWHAB EPHB2 18332218 1349868 Positive_regulation YWHAB MAP2K6 17958888 1242706 Positive_regulation YWHAB MAP2K6 25074438 1702381 Positive_regulation YWHAE NES 15251038 277762 Positive_regulation YWHAG NES 15251038 277763 Positive_regulation YY1 TNF 23226345 2724301 Positive_regulation YY1 ZFP57 20808772 2472091 Positive_regulation ZAP70 EPHB2 12591907 1526030 Positive_regulation ZAP70 ITGAL 9732296 1470772 Positive_regulation ZAP70 ITGB2 9732296 1470769 Positive_regulation ZAP70 TCN1 8627172 1596148 Positive_regulation ZBTB16 ARID4B 19278296 2266222 Positive_regulation ZBTB16 CD1D 19278296 2266219 Positive_regulation ZBTB16 EGR2 22306690 1956561 Positive_regulation ZBTB16 EGR2 22306690 1956564 Positive_regulation ZBTB16 EGR2 22306690 1956565 Positive_regulation ZBTB16 HDAC1 19278296 2266226 Positive_regulation ZBTB16 HDAC2 19278296 2266227 Positive_regulation ZBTB16 MYLIP 24223174 2876575 Positive_regulation ZBTB16 PIK3CA 23144713 2714235 Positive_regulation ZBTB16 PIK3R1 23144713 2714236 Positive_regulation ZBTB16 RBBP4 19278296 2266228 Positive_regulation ZBTB16 RBBP7 19278296 2266229 Positive_regulation ZBTB16 SAP130 19278296 2266225 Positive_regulation ZBTB16 SAP30 19278296 2266221 Positive_regulation ZBTB16 SIN3A 19278296 2266223 Positive_regulation ZBTB16 SUDS3 19278296 2266224 Positive_regulation ZBTB46 HBEGF 23913046 1959068 Positive_regulation ZC3H10 PPBP 24470144 2098033 Positive_regulation ZC3H12A EPHB2 20137095 375155 Positive_regulation ZC3H12A EPHB2 20137095 375189 Positive_regulation ZC3H13 PPBP 24470144 2098029 Positive_regulation ZC3H14 PPBP 24470144 2098030 Positive_regulation ZC3H15 PPBP 24470144 2098035 Positive_regulation ZC3H18 PPBP 24470144 2098032 Positive_regulation ZC3H3 PPBP 24470144 2098034 Positive_regulation ZC3H4 PPBP 24470144 2098028 Positive_regulation ZC3H6 PPBP 24470144 2098031 Positive_regulation ZC3H8 PPBP 24470144 2098036 Positive_regulation ZEB1 EPHB2 24318272 2186014 Positive_regulation ZEB1 HBEGF 22592159 1630916 Positive_regulation ZEB1 IL1R2 25277175 2202874 Positive_regulation ZEB1 ITGA9 24391925 2904968 Positive_regulation ZEB1 JAG1 21224847 768963 Positive_regulation ZEB1 MAP2K6 24318272 2186020 Positive_regulation ZEB1 TGM2 22225906 469612 Positive_regulation ZEB1 TGM2 22655269 940657 Positive_regulation ZEB1 TNF 22315958 469767 Positive_regulation ZEB1 TP63 20041147 2435478 Positive_regulation ZEB2 IL1R2 25277175 2202877 Positive_regulation ZEB2 TGM2 22225906 469614 Positive_regulation ZEB2 TNF 22426696 14559 Positive_regulation ZFP36 CAPN8 21731431 1091128 Positive_regulation ZFP36 EPHB2 20644716 2455971 Positive_regulation ZFP36 EPHB2 22433566 377497 Positive_regulation ZFP36 EPHB2 23109291 779271 Positive_regulation ZFP36 MAP2K6 24855454 1627896 Positive_regulation ZFP36 RNASE1 19729507 2047367 Positive_regulation ZFP36 RNASE7 19729507 2047375 Positive_regulation ZFP36 TNF 12823857 99878 Positive_regulation ZFP36 TNF 12823857 99882 Positive_regulation ZFP36 TNF 12823857 99885 Positive_regulation ZFP36 TNF 17392586 1741405 Positive_regulation ZFP36 TNF 19198593 1952251 Positive_regulation ZFP36 TNF 22437419 1708992 Positive_regulation ZFP36 TNF 23468959 2760293 Positive_regulation ZFP36 TNF 23905055 3188168 Positive_regulation ZFP36 TNF 24086143 2350905 Positive_regulation ZFP36 TNF PMC2834070 134564 Positive_regulation ZFP36L1 EPHB2 25106868 2103833 Positive_regulation ZFP36L1 EPHB2 25106868 2103859 Positive_regulation ZFP42 MAP2K6 20463961 2449815 Positive_regulation ZFP57 BMI1 20808772 2471943 Positive_regulation ZFP57 EBF1 23569325 1571344 Positive_regulation ZFP57 EBF1 24976683 1759909 Positive_regulation ZFP57 HDAC3 21173110 1383404 Positive_regulation ZFP57 HOXC8 20508826 1215440 Positive_regulation ZFP57 LONP2 17931718 157472 Positive_regulation ZFP57 MAPK3 24722354 2951205 Positive_regulation ZFP57 MAPK3 24722354 2951342 Positive_regulation ZFP57 NANOG 21915945 3171680 Positive_regulation ZFP57 PAEP 20460361 1499305 Positive_regulation ZFP57 SAFB 17931718 157471 Positive_regulation ZFP57 TRIM28 22055183 1877641 Positive_regulation ZFP57 TRIM28 23451074 2757432 Positive_regulation ZFP57 TRIM28 PMC3848115 3125629 Positive_regulation ZGLP1 CCND1 24843404 1492968 Positive_regulation ZGLP1 EPHB2 20071600 712775 Positive_regulation ZGLP1 EPHB2 23984340 183388 Positive_regulation ZGLP1 EPHB2 24045836 733820 Positive_regulation ZGLP1 FOXO1 22013015 720938 Positive_regulation ZGLP1 GLP1R 19861722 1167093 Positive_regulation ZGLP1 GLP1R 22120969 14048 Positive_regulation ZGLP1 GLP1R 22120969 14076 Positive_regulation ZGLP1 GLP1R 23284795 2731006 Positive_regulation ZGLP1 GLP1R 23969997 839539 Positive_regulation ZGLP1 GLP1R 24327600 787518 Positive_regulation ZGLP1 GLP1R 24843641 1494201 Positive_regulation ZGLP1 GLP1R 24927416 2980267 Positive_regulation ZGLP1 GLP1R 25045704 195038 Positive_regulation ZGLP1 GPR115 19092995 2402547 Positive_regulation ZGLP1 GPR115 22577369 832964 Positive_regulation ZGLP1 GPR115 25187821 845028 Positive_regulation ZGLP1 GPR132 19092995 2402536 Positive_regulation ZGLP1 GPR132 22577369 832953 Positive_regulation ZGLP1 GPR132 25187821 845017 Positive_regulation ZGLP1 GPR87 19092995 2402616 Positive_regulation ZGLP1 GPR87 22577369 833033 Positive_regulation ZGLP1 GPR87 25187821 845097 Positive_regulation ZIC1 MSX1 24550838 964111 Positive_regulation ZIC2 ALAS2 22369568 336014 Positive_regulation ZIC2 FOXD4 25234468 1884090 Positive_regulation ZIC4 ZIC2 20199689 255426 Positive_regulation ZMYM2 PGC 22453831 1933600 Positive_regulation ZNF10 TNF 18802666 1147491 Positive_regulation ZNF10 TNF 20577653 1910743 Positive_regulation ZNF10 TNF 21488180 3231939 Positive_regulation ZNF100 TNF 18802666 1147492 Positive_regulation ZNF100 TNF 20577653 1910744 Positive_regulation ZNF100 TNF 21488180 3231940 Positive_regulation ZNF101 TNF 18802666 1147493 Positive_regulation ZNF101 TNF 20577653 1910745 Positive_regulation ZNF101 TNF 21488180 3231941 Positive_regulation ZNF106 TNF 18802666 1147494 Positive_regulation ZNF106 TNF 20577653 1910746 Positive_regulation ZNF106 TNF 21488180 3231942 Positive_regulation ZNF107 TNF 18802666 1147495 Positive_regulation ZNF107 TNF 20577653 1910747 Positive_regulation ZNF107 TNF 21488180 3231943 Positive_regulation ZNF112 TNF 18802666 1147496 Positive_regulation ZNF112 TNF 20577653 1910748 Positive_regulation ZNF112 TNF 21488180 3231944 Positive_regulation ZNF114 TNF 18802666 1147497 Positive_regulation ZNF114 TNF 20577653 1910749 Positive_regulation ZNF114 TNF 21488180 3231945 Positive_regulation ZNF117 TNF 18802666 1147498 Positive_regulation ZNF117 TNF 20577653 1910750 Positive_regulation ZNF117 TNF 21488180 3231946 Positive_regulation ZNF12 TNF 18802666 1147499 Positive_regulation ZNF12 TNF 20577653 1910751 Positive_regulation ZNF12 TNF 21488180 3231947 Positive_regulation ZNF121 TNF 18802666 1147500 Positive_regulation ZNF121 TNF 20577653 1910752 Positive_regulation ZNF121 TNF 21488180 3231948 Positive_regulation ZNF124 TNF 18802666 1147501 Positive_regulation ZNF124 TNF 20577653 1910753 Positive_regulation ZNF124 TNF 21488180 3231949 Positive_regulation ZNF131 TNF 18802666 1147502 Positive_regulation ZNF131 TNF 20577653 1910754 Positive_regulation ZNF131 TNF 21488180 3231950 Positive_regulation ZNF132 TNF 18802666 1147503 Positive_regulation ZNF132 TNF 20577653 1910755 Positive_regulation ZNF132 TNF 21488180 3231951 Positive_regulation ZNF133 TNF 18802666 1147504 Positive_regulation ZNF133 TNF 20577653 1910756 Positive_regulation ZNF133 TNF 21488180 3231952 Positive_regulation ZNF134 TNF 18802666 1147505 Positive_regulation ZNF134 TNF 20577653 1910757 Positive_regulation ZNF134 TNF 21488180 3231953 Positive_regulation ZNF135 TNF 18802666 1147506 Positive_regulation ZNF135 TNF 20577653 1910758 Positive_regulation ZNF135 TNF 21488180 3231954 Positive_regulation ZNF136 TNF 18802666 1147507 Positive_regulation ZNF136 TNF 20577653 1910759 Positive_regulation ZNF136 TNF 21488180 3231955 Positive_regulation ZNF138 TNF 18802666 1147508 Positive_regulation ZNF138 TNF 20577653 1910760 Positive_regulation ZNF138 TNF 21488180 3231956 Positive_regulation ZNF14 TNF 18802666 1147509 Positive_regulation ZNF14 TNF 20577653 1910761 Positive_regulation ZNF14 TNF 21488180 3231957 Positive_regulation ZNF140 TNF 18802666 1147510 Positive_regulation ZNF140 TNF 20577653 1910762 Positive_regulation ZNF140 TNF 21488180 3231958 Positive_regulation ZNF141 TNF 18802666 1147511 Positive_regulation ZNF141 TNF 20577653 1910763 Positive_regulation ZNF141 TNF 21488180 3231959 Positive_regulation ZNF142 TNF 18802666 1147512 Positive_regulation ZNF142 TNF 20577653 1910764 Positive_regulation ZNF142 TNF 21488180 3231960 Positive_regulation ZNF143 TNF 18802666 1147513 Positive_regulation ZNF143 TNF 20577653 1910765 Positive_regulation ZNF143 TNF 21488180 3231961 Positive_regulation ZNF146 TNF 18802666 1147514 Positive_regulation ZNF146 TNF 20577653 1910766 Positive_regulation ZNF146 TNF 21488180 3231962 Positive_regulation ZNF148 TNF 18802666 1147515 Positive_regulation ZNF148 TNF 20577653 1910767 Positive_regulation ZNF148 TNF 21488180 3231963 Positive_regulation ZNF154 TNF 18802666 1147516 Positive_regulation ZNF154 TNF 20577653 1910768 Positive_regulation ZNF154 TNF 21488180 3231964 Positive_regulation ZNF155 TNF 18802666 1147517 Positive_regulation ZNF155 TNF 20577653 1910769 Positive_regulation ZNF155 TNF 21488180 3231965 Positive_regulation ZNF157 TNF 18802666 1147518 Positive_regulation ZNF157 TNF 20577653 1910770 Positive_regulation ZNF157 TNF 21488180 3231966 Positive_regulation ZNF16 TNF 18802666 1147520 Positive_regulation ZNF16 TNF 20577653 1910772 Positive_regulation ZNF16 TNF 21488180 3231968 Positive_regulation ZNF160 TNF 18802666 1147521 Positive_regulation ZNF160 TNF 20577653 1910773 Positive_regulation ZNF160 TNF 21488180 3231969 Positive_regulation ZNF165 TNF 18802666 1147522 Positive_regulation ZNF165 TNF 20577653 1910774 Positive_regulation ZNF165 TNF 21488180 3231970 Positive_regulation ZNF169 TNF 18802666 1147523 Positive_regulation ZNF169 TNF 20577653 1910775 Positive_regulation ZNF169 TNF 21488180 3231971 Positive_regulation ZNF17 TNF 18802666 1147524 Positive_regulation ZNF17 TNF 20577653 1910776 Positive_regulation ZNF17 TNF 21488180 3231972 Positive_regulation ZNF174 TNF 18802666 1147525 Positive_regulation ZNF174 TNF 20577653 1910777 Positive_regulation ZNF174 TNF 21488180 3231973 Positive_regulation ZNF175 TNF 18802666 1147526 Positive_regulation ZNF175 TNF 20577653 1910778 Positive_regulation ZNF175 TNF 21488180 3231974 Positive_regulation ZNF177 TNF 18802666 1147527 Positive_regulation ZNF177 TNF 20577653 1910779 Positive_regulation ZNF177 TNF 21488180 3231975 Positive_regulation ZNF18 TNF 18802666 1147528 Positive_regulation ZNF18 TNF 20577653 1910780 Positive_regulation ZNF18 TNF 21488180 3231976 Positive_regulation ZNF180 TNF 18802666 1147529 Positive_regulation ZNF180 TNF 20577653 1910781 Positive_regulation ZNF180 TNF 21488180 3231977 Positive_regulation ZNF181 TNF 18802666 1147530 Positive_regulation ZNF181 TNF 20577653 1910782 Positive_regulation ZNF181 TNF 21488180 3231978 Positive_regulation ZNF182 TNF 18802666 1147544 Positive_regulation ZNF182 TNF 20577653 1910796 Positive_regulation ZNF182 TNF 21488180 3231992 Positive_regulation ZNF184 TNF 18802666 1147531 Positive_regulation ZNF184 TNF 20577653 1910783 Positive_regulation ZNF184 TNF 21488180 3231979 Positive_regulation ZNF185 TNF 18802666 1147532 Positive_regulation ZNF185 TNF 20577653 1910784 Positive_regulation ZNF185 TNF 21488180 3231980 Positive_regulation ZNF189 TNF 18802666 1147533 Positive_regulation ZNF189 TNF 20577653 1910785 Positive_regulation ZNF189 TNF 21488180 3231981 Positive_regulation ZNF19 TNF 18802666 1147534 Positive_regulation ZNF19 TNF 20577653 1910786 Positive_regulation ZNF19 TNF 21488180 3231982 Positive_regulation ZNF195 TNF 18802666 1147535 Positive_regulation ZNF195 TNF 20577653 1910787 Positive_regulation ZNF195 TNF 21488180 3231983 Positive_regulation ZNF197 TNF 18802666 1147536 Positive_regulation ZNF197 TNF 20577653 1910788 Positive_regulation ZNF197 TNF 21488180 3231984 Positive_regulation ZNF2 TNF 18802666 1147537 Positive_regulation ZNF2 TNF 20577653 1910789 Positive_regulation ZNF2 TNF 21488180 3231985 Positive_regulation ZNF20 TNF 18802666 1147538 Positive_regulation ZNF20 TNF 20577653 1910790 Positive_regulation ZNF20 TNF 21488180 3231986 Positive_regulation ZNF200 TNF 18802666 1147539 Positive_regulation ZNF200 TNF 20577653 1910791 Positive_regulation ZNF200 TNF 21488180 3231987 Positive_regulation ZNF202 TNF 18802666 1147540 Positive_regulation ZNF202 TNF 20577653 1910792 Positive_regulation ZNF202 TNF 21488180 3231988 Positive_regulation ZNF205 TNF 18802666 1147541 Positive_regulation ZNF205 TNF 20577653 1910793 Positive_regulation ZNF205 TNF 21488180 3231989 Positive_regulation ZNF207 TNF 18802666 1147542 Positive_regulation ZNF207 TNF 20577653 1910794 Positive_regulation ZNF207 TNF 21488180 3231990 Positive_regulation ZNF208 TNF 18802666 1147543 Positive_regulation ZNF208 TNF 20577653 1910795 Positive_regulation ZNF208 TNF 21488180 3231991 Positive_regulation ZNF211 TNF 18802666 1147545 Positive_regulation ZNF211 TNF 20577653 1910797 Positive_regulation ZNF211 TNF 21488180 3231993 Positive_regulation ZNF212 TNF 18802666 1147546 Positive_regulation ZNF212 TNF 20577653 1910798 Positive_regulation ZNF212 TNF 21488180 3231994 Positive_regulation ZNF213 TNF 18802666 1147547 Positive_regulation ZNF213 TNF 20577653 1910799 Positive_regulation ZNF213 TNF 21488180 3231995 Positive_regulation ZNF214 TNF 18802666 1147548 Positive_regulation ZNF214 TNF 20577653 1910800 Positive_regulation ZNF214 TNF 21488180 3231996 Positive_regulation ZNF215 TNF 18802666 1147549 Positive_regulation ZNF215 TNF 20577653 1910801 Positive_regulation ZNF215 TNF 21488180 3231997 Positive_regulation ZNF217 FOXA1 24962896 347811 Positive_regulation ZNF217 PGC 22453831 1933601 Positive_regulation ZNF217 TNF 18802666 1147550 Positive_regulation ZNF217 TNF 20577653 1910802 Positive_regulation ZNF217 TNF 21488180 3231998 Positive_regulation ZNF219 TNF 18802666 1147551 Positive_regulation ZNF219 TNF 20577653 1910803 Positive_regulation ZNF219 TNF 21488180 3231999 Positive_regulation ZNF22 TNF 18802666 1147552 Positive_regulation ZNF22 TNF 20577653 1910804 Positive_regulation ZNF22 TNF 21488180 3232000 Positive_regulation ZNF221 TNF 18802666 1147553 Positive_regulation ZNF221 TNF 20577653 1910805 Positive_regulation ZNF221 TNF 21488180 3232001 Positive_regulation ZNF222 TNF 18802666 1147554 Positive_regulation ZNF222 TNF 20577653 1910806 Positive_regulation ZNF222 TNF 21488180 3232002 Positive_regulation ZNF223 TNF 18802666 1147555 Positive_regulation ZNF223 TNF 20577653 1910807 Positive_regulation ZNF223 TNF 21488180 3232003 Positive_regulation ZNF224 TNF 18802666 1147556 Positive_regulation ZNF224 TNF 20577653 1910808 Positive_regulation ZNF224 TNF 21488180 3232004 Positive_regulation ZNF225 TNF 18802666 1147557 Positive_regulation ZNF225 TNF 20577653 1910809 Positive_regulation ZNF225 TNF 21488180 3232005 Positive_regulation ZNF226 TNF 18802666 1147558 Positive_regulation ZNF226 TNF 20577653 1910810 Positive_regulation ZNF226 TNF 21488180 3232006 Positive_regulation ZNF227 TNF 18802666 1147559 Positive_regulation ZNF227 TNF 20577653 1910811 Positive_regulation ZNF227 TNF 21488180 3232007 Positive_regulation ZNF229 TNF 18802666 1147560 Positive_regulation ZNF229 TNF 20577653 1910812 Positive_regulation ZNF229 TNF 21488180 3232008 Positive_regulation ZNF23 TNF 18802666 1147561 Positive_regulation ZNF23 TNF 20577653 1910813 Positive_regulation ZNF23 TNF 21488180 3232009 Positive_regulation ZNF230 TNF 18802666 1147562 Positive_regulation ZNF230 TNF 20577653 1910814 Positive_regulation ZNF230 TNF 21488180 3232010 Positive_regulation ZNF232 TNF 18802666 1147563 Positive_regulation ZNF232 TNF 20577653 1910815 Positive_regulation ZNF232 TNF 21488180 3232011 Positive_regulation ZNF233 TNF 18802666 1147927 Positive_regulation ZNF233 TNF 20577653 1911179 Positive_regulation ZNF233 TNF 21488180 3232375 Positive_regulation ZNF234 TNF 18802666 1147564 Positive_regulation ZNF234 TNF 20577653 1910816 Positive_regulation ZNF234 TNF 21488180 3232012 Positive_regulation ZNF235 TNF 18802666 1147490 Positive_regulation ZNF235 TNF 20577653 1910742 Positive_regulation ZNF235 TNF 21488180 3231938 Positive_regulation ZNF236 TNF 18802666 1147565 Positive_regulation ZNF236 TNF 20577653 1910817 Positive_regulation ZNF236 TNF 21488180 3232013 Positive_regulation ZNF239 TNF 18802666 1147566 Positive_regulation ZNF239 TNF 20577653 1910818 Positive_regulation ZNF239 TNF 21488180 3232014 Positive_regulation ZNF24 TNF 18802666 1147567 Positive_regulation ZNF24 TNF 20577653 1910819 Positive_regulation ZNF24 TNF 21488180 3232015 Positive_regulation ZNF248 TNF 18802666 1147568 Positive_regulation ZNF248 TNF 20577653 1910820 Positive_regulation ZNF248 TNF 21488180 3232016 Positive_regulation ZNF25 TNF 18802666 1147569 Positive_regulation ZNF25 TNF 20577653 1910821 Positive_regulation ZNF25 TNF 21488180 3232017 Positive_regulation ZNF250 TNF 18802666 1147570 Positive_regulation ZNF250 TNF 20577653 1910822 Positive_regulation ZNF250 TNF 21488180 3232018 Positive_regulation ZNF251 TNF 18802666 1147571 Positive_regulation ZNF251 TNF 20577653 1910823 Positive_regulation ZNF251 TNF 21488180 3232019 Positive_regulation ZNF253 TNF 18802666 1147628 Positive_regulation ZNF253 TNF 20577653 1910880 Positive_regulation ZNF253 TNF 21488180 3232076 Positive_regulation ZNF254 TNF 18802666 1147572 Positive_regulation ZNF254 TNF 20577653 1910824 Positive_regulation ZNF254 TNF 21488180 3232020 Positive_regulation ZNF256 TNF 18802666 1147573 Positive_regulation ZNF256 TNF 20577653 1910825 Positive_regulation ZNF256 TNF 21488180 3232021 Positive_regulation ZNF257 TNF 18802666 1147629 Positive_regulation ZNF257 TNF 20577653 1910881 Positive_regulation ZNF257 TNF 21488180 3232077 Positive_regulation ZNF259 TNF 18802666 1147574 Positive_regulation ZNF259 TNF 20577653 1910826 Positive_regulation ZNF259 TNF 21488180 3232022 Positive_regulation ZNF26 TNF 18802666 1147575 Positive_regulation ZNF26 TNF 20577653 1910827 Positive_regulation ZNF26 TNF 21488180 3232023 Positive_regulation ZNF260 TNF 18802666 1147630 Positive_regulation ZNF260 TNF 20577653 1910882 Positive_regulation ZNF260 TNF 21488180 3232078 Positive_regulation ZNF263 TNF 18802666 1147576 Positive_regulation ZNF263 TNF 20577653 1910828 Positive_regulation ZNF263 TNF 21488180 3232024 Positive_regulation ZNF264 TNF 18802666 1147577 Positive_regulation ZNF264 TNF 20577653 1910829 Positive_regulation ZNF264 TNF 21488180 3232025 Positive_regulation ZNF266 TNF 18802666 1147578 Positive_regulation ZNF266 TNF 20577653 1910830 Positive_regulation ZNF266 TNF 21488180 3232026 Positive_regulation ZNF267 TNF 18802666 1147579 Positive_regulation ZNF267 TNF 20577653 1910831 Positive_regulation ZNF267 TNF 21488180 3232027 Positive_regulation ZNF268 TNF 18802666 1147580 Positive_regulation ZNF268 TNF 20577653 1910832 Positive_regulation ZNF268 TNF 21488180 3232028 Positive_regulation ZNF271 TNF 18802666 1147581 Positive_regulation ZNF271 TNF 20577653 1910833 Positive_regulation ZNF271 TNF 21488180 3232029 Positive_regulation ZNF273 TNF 18802666 1147582 Positive_regulation ZNF273 TNF 20577653 1910834 Positive_regulation ZNF273 TNF 21488180 3232030 Positive_regulation ZNF274 TNF 18802666 1147583 Positive_regulation ZNF274 TNF 20577653 1910835 Positive_regulation ZNF274 TNF 21488180 3232031 Positive_regulation ZNF275 TNF 18802666 1147584 Positive_regulation ZNF275 TNF 20577653 1910836 Positive_regulation ZNF275 TNF 21488180 3232032 Positive_regulation ZNF276 TNF 18802666 1147733 Positive_regulation ZNF276 TNF 20577653 1910985 Positive_regulation ZNF276 TNF 21488180 3232181 Positive_regulation ZNF277 TNF 18802666 1147585 Positive_regulation ZNF277 TNF 20577653 1910837 Positive_regulation ZNF277 TNF 21488180 3232033 Positive_regulation ZNF28 TNF 18802666 1147586 Positive_regulation ZNF28 TNF 20577653 1910838 Positive_regulation ZNF28 TNF 21488180 3232034 Positive_regulation ZNF281 TNF 18802666 1147587 Positive_regulation ZNF281 TNF 20577653 1910839 Positive_regulation ZNF281 TNF 21488180 3232035 Positive_regulation ZNF282 TNF 18802666 1147588 Positive_regulation ZNF282 TNF 20577653 1910840 Positive_regulation ZNF282 TNF 21488180 3232036 Positive_regulation ZNF283 TNF 18802666 1147589 Positive_regulation ZNF283 TNF 20577653 1910841 Positive_regulation ZNF283 TNF 21488180 3232037 Positive_regulation ZNF284 TNF 18802666 1147590 Positive_regulation ZNF284 TNF 20577653 1910842 Positive_regulation ZNF284 TNF 21488180 3232038 Positive_regulation ZNF285 TNF 18802666 1147591 Positive_regulation ZNF285 TNF 20577653 1910843 Positive_regulation ZNF285 TNF 21488180 3232039 Positive_regulation ZNF287 TNF 18802666 1147631 Positive_regulation ZNF287 TNF 20577653 1910883 Positive_regulation ZNF287 TNF 21488180 3232079 Positive_regulation ZNF292 TNF 18802666 1147671 Positive_regulation ZNF292 TNF 20577653 1910923 Positive_regulation ZNF292 TNF 21488180 3232119 Positive_regulation ZNF296 TNF 18802666 1147649 Positive_regulation ZNF296 TNF 20577653 1910901 Positive_regulation ZNF296 TNF 21488180 3232097 Positive_regulation ZNF3 TNF 18802666 1147592 Positive_regulation ZNF3 TNF 20577653 1910844 Positive_regulation ZNF3 TNF 21488180 3232040 Positive_regulation ZNF30 TNF 18802666 1147593 Positive_regulation ZNF30 TNF 20577653 1910845 Positive_regulation ZNF30 TNF 21488180 3232041 Positive_regulation ZNF300 TNF 18802666 1147594 Positive_regulation ZNF300 TNF 20577653 1910846 Positive_regulation ZNF300 TNF 21488180 3232042 Positive_regulation ZNF302 TNF 18802666 1147639 Positive_regulation ZNF302 TNF 20577653 1910891 Positive_regulation ZNF302 TNF 21488180 3232087 Positive_regulation ZNF304 TNF 18802666 1147632 Positive_regulation ZNF304 TNF 20577653 1910884 Positive_regulation ZNF304 TNF 21488180 3232080 Positive_regulation ZNF311 TNF 18802666 1147638 Positive_regulation ZNF311 TNF 20577653 1910890 Positive_regulation ZNF311 TNF 21488180 3232086 Positive_regulation ZNF316 TNF 18802666 1147637 Positive_regulation ZNF316 TNF 20577653 1910889 Positive_regulation ZNF316 TNF 21488180 3232085 Positive_regulation ZNF317 TNF 18802666 1147633 Positive_regulation ZNF317 TNF 20577653 1910885 Positive_regulation ZNF317 TNF 21488180 3232081 Positive_regulation ZNF318 TNF 18802666 1147634 Positive_regulation ZNF318 TNF 20577653 1910886 Positive_regulation ZNF318 TNF 21488180 3232082 Positive_regulation ZNF319 TNF 18802666 1147635 Positive_regulation ZNF319 TNF 20577653 1910887 Positive_regulation ZNF319 TNF 21488180 3232083 Positive_regulation ZNF32 TNF 18802666 1147595 Positive_regulation ZNF32 TNF 20577653 1910847 Positive_regulation ZNF32 TNF 21488180 3232043 Positive_regulation ZNF320 TNF 18802666 1147636 Positive_regulation ZNF320 TNF 20577653 1910888 Positive_regulation ZNF320 TNF 21488180 3232084 Positive_regulation ZNF322 TNF 18802666 1147740 Positive_regulation ZNF322 TNF 20577653 1910992 Positive_regulation ZNF322 TNF 21488180 3232188 Positive_regulation ZNF324 TNF 18802666 1147640 Positive_regulation ZNF324 TNF 20577653 1910892 Positive_regulation ZNF324 TNF 21488180 3232088 Positive_regulation ZNF326 TNF 18802666 1147641 Positive_regulation ZNF326 TNF 20577653 1910893 Positive_regulation ZNF326 TNF 21488180 3232089 Positive_regulation ZNF329 TNF 18802666 1147642 Positive_regulation ZNF329 TNF 20577653 1910894 Positive_regulation ZNF329 TNF 21488180 3232090 Positive_regulation ZNF330 TNF 18802666 1147643 Positive_regulation ZNF330 TNF 20577653 1910895 Positive_regulation ZNF330 TNF 21488180 3232091 Positive_regulation ZNF331 TNF 18802666 1147644 Positive_regulation ZNF331 TNF 20577653 1910896 Positive_regulation ZNF331 TNF 21488180 3232092 Positive_regulation ZNF333 TNF 18802666 1147645 Positive_regulation ZNF333 TNF 20577653 1910897 Positive_regulation ZNF333 TNF 21488180 3232093 Positive_regulation ZNF334 TNF 18802666 1147646 Positive_regulation ZNF334 TNF 20577653 1910898 Positive_regulation ZNF334 TNF 21488180 3232094 Positive_regulation ZNF335 NES 25329792 3016297 Positive_regulation ZNF335 TNF 18802666 1147647 Positive_regulation ZNF335 TNF 20577653 1910899 Positive_regulation ZNF335 TNF 21488180 3232095 Positive_regulation ZNF337 TNF 18802666 1147648 Positive_regulation ZNF337 TNF 20577653 1910900 Positive_regulation ZNF337 TNF 21488180 3232096 Positive_regulation ZNF34 TNF 18802666 1147596 Positive_regulation ZNF34 TNF 20577653 1910848 Positive_regulation ZNF34 TNF 21488180 3232044 Positive_regulation ZNF341 TNF 18802666 1147650 Positive_regulation ZNF341 TNF 20577653 1910902 Positive_regulation ZNF341 TNF 21488180 3232098 Positive_regulation ZNF343 TNF 18802666 1147651 Positive_regulation ZNF343 TNF 20577653 1910903 Positive_regulation ZNF343 TNF 21488180 3232099 Positive_regulation ZNF345 TNF 18802666 1147654 Positive_regulation ZNF345 TNF 20577653 1910906 Positive_regulation ZNF345 TNF 21488180 3232102 Positive_regulation ZNF346 TNF 18802666 1147655 Positive_regulation ZNF346 TNF 20577653 1910907 Positive_regulation ZNF346 TNF 21488180 3232103 Positive_regulation ZNF347 TNF 18802666 1147656 Positive_regulation ZNF347 TNF 20577653 1910908 Positive_regulation ZNF347 TNF 21488180 3232104 Positive_regulation ZNF35 TNF 18802666 1147597 Positive_regulation ZNF35 TNF 20577653 1910849 Positive_regulation ZNF35 TNF 21488180 3232045 Positive_regulation ZNF350 TNF 18802666 1147657 Positive_regulation ZNF350 TNF 20577653 1910909 Positive_regulation ZNF350 TNF 21488180 3232105 Positive_regulation ZNF358 TNF 18802666 1147661 Positive_regulation ZNF358 TNF 20577653 1910913 Positive_regulation ZNF358 TNF 21488180 3232109 Positive_regulation ZNF362 TNF 18802666 1147665 Positive_regulation ZNF362 TNF 20577653 1910917 Positive_regulation ZNF362 TNF 21488180 3232113 Positive_regulation ZNF365 TNF 18802666 1147667 Positive_regulation ZNF365 TNF 20577653 1910919 Positive_regulation ZNF365 TNF 21488180 3232115 Positive_regulation ZNF366 TNF 18802666 1147668 Positive_regulation ZNF366 TNF 20577653 1910920 Positive_regulation ZNF366 TNF 21488180 3232116 Positive_regulation ZNF367 TNF 18802666 1147669 Positive_regulation ZNF367 TNF 20577653 1910921 Positive_regulation ZNF367 TNF 21488180 3232117 Positive_regulation ZNF382 TNF 18802666 1147662 Positive_regulation ZNF382 TNF 20577653 1910914 Positive_regulation ZNF382 TNF 21488180 3232110 Positive_regulation ZNF383 TNF 18802666 1147672 Positive_regulation ZNF383 TNF 20577653 1910924 Positive_regulation ZNF383 TNF 21488180 3232120 Positive_regulation ZNF384 TNF 18802666 1147489 Positive_regulation ZNF384 TNF 20577653 1910741 Positive_regulation ZNF384 TNF 21488180 3231937 Positive_regulation ZNF391 TNF 18802666 1147674 Positive_regulation ZNF391 TNF 20577653 1910926 Positive_regulation ZNF391 TNF 21488180 3232122 Positive_regulation ZNF394 TNF 18802666 1147677 Positive_regulation ZNF394 TNF 20577653 1910929 Positive_regulation ZNF394 TNF 21488180 3232125 Positive_regulation ZNF395 TNF 18802666 1147673 Positive_regulation ZNF395 TNF 20577653 1910925 Positive_regulation ZNF395 TNF 21488180 3232121 Positive_regulation ZNF396 TNF 18802666 1147676 Positive_regulation ZNF396 TNF 20577653 1910928 Positive_regulation ZNF396 TNF 21488180 3232124 Positive_regulation ZNF397 TNF 18802666 1147675 Positive_regulation ZNF397 TNF 20577653 1910927 Positive_regulation ZNF397 TNF 21488180 3232123 Positive_regulation ZNF398 TNF 18802666 1147670 Positive_regulation ZNF398 TNF 20577653 1910922 Positive_regulation ZNF398 TNF 21488180 3232118 Positive_regulation ZNF404 TNF 18802666 1147678 Positive_regulation ZNF404 TNF 20577653 1910930 Positive_regulation ZNF404 TNF 21488180 3232126 Positive_regulation ZNF407 TNF 18802666 1147679 Positive_regulation ZNF407 TNF 20577653 1910931 Positive_regulation ZNF407 TNF 21488180 3232127 Positive_regulation ZNF408 TNF 18802666 1147680 Positive_regulation ZNF408 TNF 20577653 1910932 Positive_regulation ZNF408 TNF 21488180 3232128 Positive_regulation ZNF41 TNF 18802666 1147598 Positive_regulation ZNF41 TNF 20577653 1910850 Positive_regulation ZNF41 TNF 21488180 3232046 Positive_regulation ZNF410 TNF 18802666 1147681 Positive_regulation ZNF410 TNF 20577653 1910933 Positive_regulation ZNF410 TNF 21488180 3232129 Positive_regulation ZNF414 TNF 18802666 1147685 Positive_regulation ZNF414 TNF 20577653 1910937 Positive_regulation ZNF414 TNF 21488180 3232133 Positive_regulation ZNF415 TNF 18802666 1147686 Positive_regulation ZNF415 TNF 20577653 1910938 Positive_regulation ZNF415 TNF 21488180 3232134 Positive_regulation ZNF416 TNF 18802666 1147687 Positive_regulation ZNF416 TNF 20577653 1910939 Positive_regulation ZNF416 TNF 21488180 3232135 Positive_regulation ZNF417 TNF 18802666 1147688 Positive_regulation ZNF417 TNF 20577653 1910940 Positive_regulation ZNF417 TNF 21488180 3232136 Positive_regulation ZNF418 TNF 18802666 1147689 Positive_regulation ZNF418 TNF 20577653 1910941 Positive_regulation ZNF418 TNF 21488180 3232137 Positive_regulation ZNF419 TNF 18802666 1147690 Positive_regulation ZNF419 TNF 20577653 1910942 Positive_regulation ZNF419 TNF 21488180 3232138 Positive_regulation ZNF420 TNF 18802666 1147691 Positive_regulation ZNF420 TNF 20577653 1910943 Positive_regulation ZNF420 TNF 21488180 3232139 Positive_regulation ZNF423 TNF 18802666 1147660 Positive_regulation ZNF423 TNF 20577653 1910912 Positive_regulation ZNF423 TNF 21488180 3232108 Positive_regulation ZNF425 TNF 18802666 1147692 Positive_regulation ZNF425 TNF 20577653 1910944 Positive_regulation ZNF425 TNF 21488180 3232140 Positive_regulation ZNF426 TNF 18802666 1147693 Positive_regulation ZNF426 TNF 20577653 1910945 Positive_regulation ZNF426 TNF 21488180 3232141 Positive_regulation ZNF428 TNF 18802666 1147694 Positive_regulation ZNF428 TNF 20577653 1910946 Positive_regulation ZNF428 TNF 21488180 3232142 Positive_regulation ZNF429 TNF 18802666 1147701 Positive_regulation ZNF429 TNF 20577653 1910953 Positive_regulation ZNF429 TNF 21488180 3232149 Positive_regulation ZNF43 TNF 18802666 1147599 Positive_regulation ZNF43 TNF 20577653 1910851 Positive_regulation ZNF43 TNF 21488180 3232047 Positive_regulation ZNF430 TNF 18802666 1147696 Positive_regulation ZNF430 TNF 20577653 1910948 Positive_regulation ZNF430 TNF 21488180 3232144 Positive_regulation ZNF431 TNF 18802666 1147697 Positive_regulation ZNF431 TNF 20577653 1910949 Positive_regulation ZNF431 TNF 21488180 3232145 Positive_regulation ZNF432 TNF 18802666 1147698 Positive_regulation ZNF432 TNF 20577653 1910950 Positive_regulation ZNF432 TNF 21488180 3232146 Positive_regulation ZNF433 TNF 18802666 1147699 Positive_regulation ZNF433 TNF 20577653 1910951 Positive_regulation ZNF433 TNF 21488180 3232147 Positive_regulation ZNF436 TNF 18802666 1147700 Positive_regulation ZNF436 TNF 20577653 1910952 Positive_regulation ZNF436 TNF 21488180 3232148 Positive_regulation ZNF438 TNF 18802666 1147708 Positive_regulation ZNF438 TNF 20577653 1910960 Positive_regulation ZNF438 TNF 21488180 3232156 Positive_regulation ZNF439 TNF 18802666 1147702 Positive_regulation ZNF439 TNF 20577653 1910954 Positive_regulation ZNF439 TNF 21488180 3232150 Positive_regulation ZNF44 TNF 18802666 1147600 Positive_regulation ZNF44 TNF 20577653 1910852 Positive_regulation ZNF44 TNF 21488180 3232048 Positive_regulation ZNF440 TNF 18802666 1147703 Positive_regulation ZNF440 TNF 20577653 1910955 Positive_regulation ZNF440 TNF 21488180 3232151 Positive_regulation ZNF441 TNF 18802666 1147704 Positive_regulation ZNF441 TNF 20577653 1910956 Positive_regulation ZNF441 TNF 21488180 3232152 Positive_regulation ZNF442 TNF 18802666 1147705 Positive_regulation ZNF442 TNF 20577653 1910957 Positive_regulation ZNF442 TNF 21488180 3232153 Positive_regulation ZNF443 TNF 18802666 1147706 Positive_regulation ZNF443 TNF 20577653 1910958 Positive_regulation ZNF443 TNF 21488180 3232154 Positive_regulation ZNF444 TNF 18802666 1147652 Positive_regulation ZNF444 TNF 20577653 1910904 Positive_regulation ZNF444 TNF 21488180 3232100 Positive_regulation ZNF445 TNF 18802666 1147707 Positive_regulation ZNF445 TNF 20577653 1910959 Positive_regulation ZNF445 TNF 21488180 3232155 Positive_regulation ZNF446 TNF 18802666 1147709 Positive_regulation ZNF446 TNF 20577653 1910961 Positive_regulation ZNF446 TNF 21488180 3232157 Positive_regulation ZNF449 TNF 18802666 1147710 Positive_regulation ZNF449 TNF 20577653 1910962 Positive_regulation ZNF449 TNF 21488180 3232158 Positive_regulation ZNF45 TNF 18802666 1147601 Positive_regulation ZNF45 TNF 20577653 1910853 Positive_regulation ZNF45 TNF 21488180 3232049 Positive_regulation ZNF451 TNF 18802666 1147711 Positive_regulation ZNF451 TNF 20577653 1910963 Positive_regulation ZNF451 TNF 21488180 3232159 Positive_regulation ZNF454 TNF 18802666 1147712 Positive_regulation ZNF454 TNF 20577653 1910964 Positive_regulation ZNF454 TNF 21488180 3232160 Positive_regulation ZNF460 TNF 18802666 1147713 Positive_regulation ZNF460 TNF 20577653 1910965 Positive_regulation ZNF460 TNF 21488180 3232161 Positive_regulation ZNF461 TNF 18802666 1147714 Positive_regulation ZNF461 TNF 20577653 1910966 Positive_regulation ZNF461 TNF 21488180 3232162 Positive_regulation ZNF462 TNF 18802666 1147715 Positive_regulation ZNF462 TNF 20577653 1910967 Positive_regulation ZNF462 TNF 21488180 3232163 Positive_regulation ZNF467 TNF 18802666 1147724 Positive_regulation ZNF467 TNF 20577653 1910976 Positive_regulation ZNF467 TNF 21488180 3232172 Positive_regulation ZNF468 TNF 18802666 1147949 Positive_regulation ZNF468 TNF 20577653 1911201 Positive_regulation ZNF468 TNF 21488180 3232397 Positive_regulation ZNF469 TNF 18802666 1147726 Positive_regulation ZNF469 TNF 20577653 1910978 Positive_regulation ZNF469 TNF 21488180 3232174 Positive_regulation ZNF470 TNF 18802666 1147722 Positive_regulation ZNF470 TNF 20577653 1910974 Positive_regulation ZNF470 TNF 21488180 3232170 Positive_regulation ZNF471 TNF 18802666 1147727 Positive_regulation ZNF471 TNF 20577653 1910979 Positive_regulation ZNF471 TNF 21488180 3232175 Positive_regulation ZNF473 TNF 18802666 1147728 Positive_regulation ZNF473 TNF 20577653 1910980 Positive_regulation ZNF473 TNF 21488180 3232176 Positive_regulation ZNF474 TNF 18802666 1147729 Positive_regulation ZNF474 TNF 20577653 1910981 Positive_regulation ZNF474 TNF 21488180 3232177 Positive_regulation ZNF479 TNF 18802666 1147730 Positive_regulation ZNF479 TNF 20577653 1910982 Positive_regulation ZNF479 TNF 21488180 3232178 Positive_regulation ZNF48 TNF 18802666 1147602 Positive_regulation ZNF48 TNF 20577653 1910854 Positive_regulation ZNF48 TNF 21488180 3232050 Positive_regulation ZNF480 TNF 18802666 1147732 Positive_regulation ZNF480 TNF 20577653 1910984 Positive_regulation ZNF480 TNF 21488180 3232180 Positive_regulation ZNF483 TNF 18802666 1147734 Positive_regulation ZNF483 TNF 20577653 1910986 Positive_regulation ZNF483 TNF 21488180 3232182 Positive_regulation ZNF484 TNF 18802666 1147735 Positive_regulation ZNF484 TNF 20577653 1910987 Positive_regulation ZNF484 TNF 21488180 3232183 Positive_regulation ZNF485 TNF 18802666 1147736 Positive_regulation ZNF485 TNF 20577653 1910988 Positive_regulation ZNF485 TNF 21488180 3232184 Positive_regulation ZNF486 TNF 18802666 1147695 Positive_regulation ZNF486 TNF 20577653 1910947 Positive_regulation ZNF486 TNF 21488180 3232143 Positive_regulation ZNF487 TNF 18802666 1147737 Positive_regulation ZNF487 TNF 20577653 1910989 Positive_regulation ZNF487 TNF 21488180 3232185 Positive_regulation ZNF488 TNF 18802666 1147738 Positive_regulation ZNF488 TNF 20577653 1910990 Positive_regulation ZNF488 TNF 21488180 3232186 Positive_regulation ZNF490 TNF 18802666 1147741 Positive_regulation ZNF490 TNF 20577653 1910993 Positive_regulation ZNF490 TNF 21488180 3232189 Positive_regulation ZNF491 TNF 18802666 1147742 Positive_regulation ZNF491 TNF 20577653 1910994 Positive_regulation ZNF491 TNF 21488180 3232190 Positive_regulation ZNF492 TNF 18802666 1147743 Positive_regulation ZNF492 TNF 20577653 1910995 Positive_regulation ZNF492 TNF 21488180 3232191 Positive_regulation ZNF493 TNF 18802666 1147744 Positive_regulation ZNF493 TNF 20577653 1910996 Positive_regulation ZNF493 TNF 21488180 3232192 Positive_regulation ZNF496 TNF 18802666 1147745 Positive_regulation ZNF496 TNF 20577653 1910997 Positive_regulation ZNF496 TNF 21488180 3232193 Positive_regulation ZNF497 TNF 18802666 1147746 Positive_regulation ZNF497 TNF 20577653 1910998 Positive_regulation ZNF497 TNF 21488180 3232194 Positive_regulation ZNF500 TNF 18802666 1147747 Positive_regulation ZNF500 TNF 20577653 1910999 Positive_regulation ZNF500 TNF 21488180 3232195 Positive_regulation ZNF501 TNF 18802666 1147748 Positive_regulation ZNF501 TNF 20577653 1911000 Positive_regulation ZNF501 TNF 21488180 3232196 Positive_regulation ZNF502 TNF 18802666 1147749 Positive_regulation ZNF502 TNF 20577653 1911001 Positive_regulation ZNF502 TNF 21488180 3232197 Positive_regulation ZNF503 TNF 18802666 1147739 Positive_regulation ZNF503 TNF 20577653 1910991 Positive_regulation ZNF503 TNF 21488180 3232187 Positive_regulation ZNF506 TNF 18802666 1147750 Positive_regulation ZNF506 TNF 20577653 1911002 Positive_regulation ZNF506 TNF 21488180 3232198 Positive_regulation ZNF507 TNF 18802666 1147751 Positive_regulation ZNF507 TNF 20577653 1911003 Positive_regulation ZNF507 TNF 21488180 3232199 Positive_regulation ZNF510 TNF 18802666 1147897 Positive_regulation ZNF510 TNF 20577653 1911149 Positive_regulation ZNF510 TNF 21488180 3232345 Positive_regulation ZNF511 TNF 18802666 1147871 Positive_regulation ZNF511 TNF 20577653 1911123 Positive_regulation ZNF511 TNF 21488180 3232319 Positive_regulation ZNF512 TNF 18802666 1147904 Positive_regulation ZNF512 TNF 20577653 1911156 Positive_regulation ZNF512 TNF 21488180 3232352 Positive_regulation ZNF513 TNF 18802666 1147816 Positive_regulation ZNF513 TNF 20577653 1911068 Positive_regulation ZNF513 TNF 21488180 3232264 Positive_regulation ZNF514 TNF 18802666 1147790 Positive_regulation ZNF514 TNF 20577653 1911042 Positive_regulation ZNF514 TNF 21488180 3232238 Positive_regulation ZNF516 TNF 18802666 1147890 Positive_regulation ZNF516 TNF 20577653 1911142 Positive_regulation ZNF516 TNF 21488180 3232338 Positive_regulation ZNF517 TNF 18802666 1147851 Positive_regulation ZNF517 TNF 20577653 1911103 Positive_regulation ZNF517 TNF 21488180 3232299 Positive_regulation ZNF519 TNF 18802666 1147921 Positive_regulation ZNF519 TNF 20577653 1911173 Positive_regulation ZNF519 TNF 21488180 3232369 Positive_regulation ZNF521 TNF 18802666 1147752 Positive_regulation ZNF521 TNF 20577653 1911004 Positive_regulation ZNF521 TNF 21488180 3232200 Positive_regulation ZNF524 TNF 18802666 1147866 Positive_regulation ZNF524 TNF 20577653 1911118 Positive_regulation ZNF524 TNF 21488180 3232314 Positive_regulation ZNF525 TNF 18802666 1147910 Positive_regulation ZNF525 TNF 20577653 1911162 Positive_regulation ZNF525 TNF 21488180 3232358 Positive_regulation ZNF526 TNF 18802666 1147908 Positive_regulation ZNF526 TNF 20577653 1911160 Positive_regulation ZNF526 TNF 21488180 3232356 Positive_regulation ZNF527 TNF 18802666 1147906 Positive_regulation ZNF527 TNF 20577653 1911158 Positive_regulation ZNF527 TNF 21488180 3232354 Positive_regulation ZNF528 TNF 18802666 1147905 Positive_regulation ZNF528 TNF 20577653 1911157 Positive_regulation ZNF528 TNF 21488180 3232353 Positive_regulation ZNF529 TNF 18802666 1147903 Positive_regulation ZNF529 TNF 20577653 1911155 Positive_regulation ZNF529 TNF 21488180 3232351 Positive_regulation ZNF530 TNF 18802666 1147902 Positive_regulation ZNF530 TNF 20577653 1911154 Positive_regulation ZNF530 TNF 21488180 3232350 Positive_regulation ZNF532 TNF 18802666 1147925 Positive_regulation ZNF532 TNF 20577653 1911177 Positive_regulation ZNF532 TNF 21488180 3232373 Positive_regulation ZNF534 TNF 18802666 1147802 Positive_regulation ZNF534 TNF 20577653 1911054 Positive_regulation ZNF534 TNF 21488180 3232250 Positive_regulation ZNF536 TNF 18802666 1147894 Positive_regulation ZNF536 TNF 20577653 1911146 Positive_regulation ZNF536 TNF 21488180 3232342 Positive_regulation ZNF540 TNF 18802666 1147772 Positive_regulation ZNF540 TNF 20577653 1911024 Positive_regulation ZNF540 TNF 21488180 3232220 Positive_regulation ZNF541 TNF 18802666 1147771 Positive_regulation ZNF541 TNF 20577653 1911023 Positive_regulation ZNF541 TNF 21488180 3232219 Positive_regulation ZNF542 TNF 18802666 1147776 Positive_regulation ZNF542 TNF 20577653 1911028 Positive_regulation ZNF542 TNF 21488180 3232224 Positive_regulation ZNF543 TNF 18802666 1147769 Positive_regulation ZNF543 TNF 20577653 1911021 Positive_regulation ZNF543 TNF 21488180 3232217 Positive_regulation ZNF544 TNF 18802666 1147659 Positive_regulation ZNF544 TNF 20577653 1910911 Positive_regulation ZNF544 TNF 21488180 3232107 Positive_regulation ZNF546 TNF 18802666 1147878 Positive_regulation ZNF546 TNF 20577653 1911130 Positive_regulation ZNF546 TNF 21488180 3232326 Positive_regulation ZNF547 TNF 18802666 1147810 Positive_regulation ZNF547 TNF 20577653 1911062 Positive_regulation ZNF547 TNF 21488180 3232258 Positive_regulation ZNF548 TNF 18802666 1147817 Positive_regulation ZNF548 TNF 20577653 1911069 Positive_regulation ZNF548 TNF 21488180 3232265 Positive_regulation ZNF549 TNF 18802666 1147820 Positive_regulation ZNF549 TNF 20577653 1911072 Positive_regulation ZNF549 TNF 21488180 3232268 Positive_regulation ZNF550 TNF 18802666 1147875 Positive_regulation ZNF550 TNF 20577653 1911127 Positive_regulation ZNF550 TNF 21488180 3232323 Positive_regulation ZNF551 TNF 18802666 1147763 Positive_regulation ZNF551 TNF 20577653 1911015 Positive_regulation ZNF551 TNF 21488180 3232211 Positive_regulation ZNF552 TNF 18802666 1147797 Positive_regulation ZNF552 TNF 20577653 1911049 Positive_regulation ZNF552 TNF 21488180 3232245 Positive_regulation ZNF554 TNF 18802666 1147819 Positive_regulation ZNF554 TNF 20577653 1911071 Positive_regulation ZNF554 TNF 21488180 3232267 Positive_regulation ZNF555 TNF 18802666 1147869 Positive_regulation ZNF555 TNF 20577653 1911121 Positive_regulation ZNF555 TNF 21488180 3232317 Positive_regulation ZNF556 TNF 18802666 1147780 Positive_regulation ZNF556 TNF 20577653 1911032 Positive_regulation ZNF556 TNF 21488180 3232228 Positive_regulation ZNF557 TNF 18802666 1147874 Positive_regulation ZNF557 TNF 20577653 1911126 Positive_regulation ZNF557 TNF 21488180 3232322 Positive_regulation ZNF558 TNF 18802666 1147808 Positive_regulation ZNF558 TNF 20577653 1911060 Positive_regulation ZNF558 TNF 21488180 3232256 Positive_regulation ZNF559 TNF 18802666 1147863 Positive_regulation ZNF559 TNF 20577653 1911115 Positive_regulation ZNF559 TNF 21488180 3232311 Positive_regulation ZNF56 TNF 18802666 1147603 Positive_regulation ZNF56 TNF 20577653 1910855 Positive_regulation ZNF56 TNF 21488180 3232051 Positive_regulation ZNF560 TNF 18802666 1147814 Positive_regulation ZNF560 TNF 20577653 1911066 Positive_regulation ZNF560 TNF 21488180 3232262 Positive_regulation ZNF561 TNF 18802666 1147880 Positive_regulation ZNF561 TNF 20577653 1911132 Positive_regulation ZNF561 TNF 21488180 3232328 Positive_regulation ZNF562 TNF 18802666 1147794 Positive_regulation ZNF562 TNF 20577653 1911046 Positive_regulation ZNF562 TNF 21488180 3232242 Positive_regulation ZNF563 TNF 18802666 1147918 Positive_regulation ZNF563 TNF 20577653 1911170 Positive_regulation ZNF563 TNF 21488180 3232366 Positive_regulation ZNF564 TNF 18802666 1147933 Positive_regulation ZNF564 TNF 20577653 1911185 Positive_regulation ZNF564 TNF 21488180 3232381 Positive_regulation ZNF565 TNF 18802666 1147824 Positive_regulation ZNF565 TNF 20577653 1911076 Positive_regulation ZNF565 TNF 21488180 3232272 Positive_regulation ZNF566 TNF 18802666 1147791 Positive_regulation ZNF566 TNF 20577653 1911043 Positive_regulation ZNF566 TNF 21488180 3232239 Positive_regulation ZNF567 TNF 18802666 1147881 Positive_regulation ZNF567 TNF 20577653 1911133 Positive_regulation ZNF567 TNF 21488180 3232329 Positive_regulation ZNF568 TNF 18802666 1147775 Positive_regulation ZNF568 TNF 20577653 1911027 Positive_regulation ZNF568 TNF 21488180 3232223 Positive_regulation ZNF569 TNF 18802666 1147754 Positive_regulation ZNF569 TNF 20577653 1911006 Positive_regulation ZNF569 TNF 21488180 3232202 Positive_regulation ZNF57 TNF 18802666 1147604 Positive_regulation ZNF57 TNF 20577653 1910856 Positive_regulation ZNF57 TNF 21488180 3232052 Positive_regulation ZNF570 TNF 18802666 1147805 Positive_regulation ZNF570 TNF 20577653 1911057 Positive_regulation ZNF570 TNF 21488180 3232253 Positive_regulation ZNF571 TNF 18802666 1147760 Positive_regulation ZNF571 TNF 20577653 1911012 Positive_regulation ZNF571 TNF 21488180 3232208 Positive_regulation ZNF572 TNF 18802666 1147826 Positive_regulation ZNF572 TNF 20577653 1911078 Positive_regulation ZNF572 TNF 21488180 3232274 Positive_regulation ZNF573 TNF 18802666 1147806 Positive_regulation ZNF573 TNF 20577653 1911058 Positive_regulation ZNF573 TNF 21488180 3232254 Positive_regulation ZNF574 TNF 18802666 1147798 Positive_regulation ZNF574 TNF 20577653 1911050 Positive_regulation ZNF574 TNF 21488180 3232246 Positive_regulation ZNF575 TNF 18802666 1147845 Positive_regulation ZNF575 TNF 20577653 1911097 Positive_regulation ZNF575 TNF 21488180 3232293 Positive_regulation ZNF576 TNF 18802666 1147868 Positive_regulation ZNF576 TNF 20577653 1911120 Positive_regulation ZNF576 TNF 21488180 3232316 Positive_regulation ZNF577 TNF 18802666 1147879 Positive_regulation ZNF577 TNF 20577653 1911131 Positive_regulation ZNF577 TNF 21488180 3232327 Positive_regulation ZNF578 TNF 18802666 1147811 Positive_regulation ZNF578 TNF 20577653 1911063 Positive_regulation ZNF578 TNF 21488180 3232259 Positive_regulation ZNF579 TNF 18802666 1147821 Positive_regulation ZNF579 TNF 20577653 1911073 Positive_regulation ZNF579 TNF 21488180 3232269 Positive_regulation ZNF580 TNF 18802666 1147913 Positive_regulation ZNF580 TNF 20577653 1911165 Positive_regulation ZNF580 TNF 21488180 3232361 Positive_regulation ZNF581 TNF 18802666 1147761 Positive_regulation ZNF581 TNF 20577653 1911013 Positive_regulation ZNF581 TNF 21488180 3232209 Positive_regulation ZNF582 TNF 18802666 1147807 Positive_regulation ZNF582 TNF 20577653 1911059 Positive_regulation ZNF582 TNF 21488180 3232255 Positive_regulation ZNF583 TNF 18802666 1147809 Positive_regulation ZNF583 TNF 20577653 1911061 Positive_regulation ZNF583 TNF 21488180 3232257 Positive_regulation ZNF584 TNF 18802666 1147843 Positive_regulation ZNF584 TNF 20577653 1911095 Positive_regulation ZNF584 TNF 21488180 3232291 Positive_regulation ZNF586 TNF 18802666 1147793 Positive_regulation ZNF586 TNF 20577653 1911045 Positive_regulation ZNF586 TNF 21488180 3232241 Positive_regulation ZNF587 TNF 18802666 1147931 Positive_regulation ZNF587 TNF 20577653 1911183 Positive_regulation ZNF587 TNF 21488180 3232379 Positive_regulation ZNF589 TNF 18802666 1147658 Positive_regulation ZNF589 TNF 20577653 1910910 Positive_regulation ZNF589 TNF 21488180 3232106 Positive_regulation ZNF592 TNF 18802666 1147889 Positive_regulation ZNF592 TNF 20577653 1911141 Positive_regulation ZNF592 TNF 21488180 3232337 Positive_regulation ZNF593 TNF 18802666 1147926 Positive_regulation ZNF593 TNF 20577653 1911178 Positive_regulation ZNF593 TNF 21488180 3232374 Positive_regulation ZNF594 TNF 18802666 1147907 Positive_regulation ZNF594 TNF 20577653 1911159 Positive_regulation ZNF594 TNF 21488180 3232355 Positive_regulation ZNF595 TNF 18802666 1147837 Positive_regulation ZNF595 TNF 20577653 1911089 Positive_regulation ZNF595 TNF 21488180 3232285 Positive_regulation ZNF596 TNF 18802666 1147841 Positive_regulation ZNF596 TNF 20577653 1911093 Positive_regulation ZNF596 TNF 21488180 3232289 Positive_regulation ZNF597 TNF 18802666 1147818 Positive_regulation ZNF597 TNF 20577653 1911070 Positive_regulation ZNF597 TNF 21488180 3232266 Positive_regulation ZNF598 TNF 18802666 1147860 Positive_regulation ZNF598 TNF 20577653 1911112 Positive_regulation ZNF598 TNF 21488180 3232308 Positive_regulation ZNF599 TNF 18802666 1147804 Positive_regulation ZNF599 TNF 20577653 1911056 Positive_regulation ZNF599 TNF 21488180 3232252 Positive_regulation ZNF600 TNF 18802666 1147929 Positive_regulation ZNF600 TNF 20577653 1911181 Positive_regulation ZNF600 TNF 21488180 3232377 Positive_regulation ZNF605 TNF 18802666 1147858 Positive_regulation ZNF605 TNF 20577653 1911110 Positive_regulation ZNF605 TNF 21488180 3232306 Positive_regulation ZNF606 TNF 18802666 1147787 Positive_regulation ZNF606 TNF 20577653 1911039 Positive_regulation ZNF606 TNF 21488180 3232235 Positive_regulation ZNF607 TNF 18802666 1147862 Positive_regulation ZNF607 TNF 20577653 1911114 Positive_regulation ZNF607 TNF 21488180 3232310 Positive_regulation ZNF608 TNF 18802666 1147899 Positive_regulation ZNF608 TNF 20577653 1911151 Positive_regulation ZNF608 TNF 21488180 3232347 Positive_regulation ZNF609 TNF 18802666 1147891 Positive_regulation ZNF609 TNF 20577653 1911143 Positive_regulation ZNF609 TNF 21488180 3232339 Positive_regulation ZNF610 TNF 18802666 1147822 Positive_regulation ZNF610 TNF 20577653 1911074 Positive_regulation ZNF610 TNF 21488180 3232270 Positive_regulation ZNF611 TNF 18802666 1147885 Positive_regulation ZNF611 TNF 20577653 1911137 Positive_regulation ZNF611 TNF 21488180 3232333 Positive_regulation ZNF613 TNF 18802666 1147784 Positive_regulation ZNF613 TNF 20577653 1911036 Positive_regulation ZNF613 TNF 21488180 3232232 Positive_regulation ZNF614 TNF 18802666 1147753 Positive_regulation ZNF614 TNF 20577653 1911005 Positive_regulation ZNF614 TNF 21488180 3232201 Positive_regulation ZNF615 TNF 18802666 1147755 Positive_regulation ZNF615 TNF 20577653 1911007 Positive_regulation ZNF615 TNF 21488180 3232203 Positive_regulation ZNF616 TNF 18802666 1147856 Positive_regulation ZNF616 TNF 20577653 1911108 Positive_regulation ZNF616 TNF 21488180 3232304 Positive_regulation ZNF618 TNF 18802666 1147909 Positive_regulation ZNF618 TNF 20577653 1911161 Positive_regulation ZNF618 TNF 21488180 3232357 Positive_regulation ZNF619 TNF 18802666 1147831 Positive_regulation ZNF619 TNF 20577653 1911083 Positive_regulation ZNF619 TNF 21488180 3232279 Positive_regulation ZNF620 TNF 18802666 1147884 Positive_regulation ZNF620 TNF 20577653 1911136 Positive_regulation ZNF620 TNF 21488180 3232332 Positive_regulation ZNF621 TNF 18802666 1147758 Positive_regulation ZNF621 TNF 20577653 1911010 Positive_regulation ZNF621 TNF 21488180 3232206 Positive_regulation ZNF622 TNF 18802666 1147932 Positive_regulation ZNF622 TNF 20577653 1911184 Positive_regulation ZNF622 TNF 21488180 3232380 Positive_regulation ZNF623 TNF 18802666 1147895 Positive_regulation ZNF623 TNF 20577653 1911147 Positive_regulation ZNF623 TNF 21488180 3232343 Positive_regulation ZNF624 TNF 18802666 1147900 Positive_regulation ZNF624 TNF 20577653 1911152 Positive_regulation ZNF624 TNF 21488180 3232348 Positive_regulation ZNF625 TNF 18802666 1147920 Positive_regulation ZNF625 TNF 20577653 1911172 Positive_regulation ZNF625 TNF 21488180 3232368 Positive_regulation ZNF626 TNF 18802666 1147915 Positive_regulation ZNF626 TNF 20577653 1911167 Positive_regulation ZNF626 TNF 21488180 3232363 Positive_regulation ZNF627 TNF 18802666 1147919 Positive_regulation ZNF627 TNF 20577653 1911171 Positive_regulation ZNF627 TNF 21488180 3232367 Positive_regulation ZNF628 TNF 18802666 1147855 Positive_regulation ZNF628 TNF 20577653 1911107 Positive_regulation ZNF628 TNF 21488180 3232303 Positive_regulation ZNF629 TNF 18802666 1147893 Positive_regulation ZNF629 TNF 20577653 1911145 Positive_regulation ZNF629 TNF 21488180 3232341 Positive_regulation ZNF630 TNF 18802666 1147887 Positive_regulation ZNF630 TNF 20577653 1911139 Positive_regulation ZNF630 TNF 21488180 3232335 Positive_regulation ZNF638 TNF 18802666 1147664 Positive_regulation ZNF638 TNF 20577653 1910916 Positive_regulation ZNF638 TNF 21488180 3232112 Positive_regulation ZNF639 TNF 18802666 1147928 Positive_regulation ZNF639 TNF 20577653 1911180 Positive_regulation ZNF639 TNF 21488180 3232376 Positive_regulation ZNF641 TNF 18802666 1147934 Positive_regulation ZNF641 TNF 20577653 1911186 Positive_regulation ZNF641 TNF 21488180 3232382 Positive_regulation ZNF644 TNF 18802666 1147898 Positive_regulation ZNF644 TNF 20577653 1911150 Positive_regulation ZNF644 TNF 21488180 3232346 Positive_regulation ZNF645 TNF 18802666 1147803 Positive_regulation ZNF645 TNF 20577653 1911055 Positive_regulation ZNF645 TNF 21488180 3232251 Positive_regulation ZNF646 TNF 18802666 1147892 Positive_regulation ZNF646 TNF 20577653 1911144 Positive_regulation ZNF646 TNF 21488180 3232340 Positive_regulation ZNF648 TNF 18802666 1147666 Positive_regulation ZNF648 TNF 20577653 1910918 Positive_regulation ZNF648 TNF 21488180 3232114 Positive_regulation ZNF649 TNF 18802666 1147782 Positive_regulation ZNF649 TNF 20577653 1911034 Positive_regulation ZNF649 TNF 21488180 3232230 Positive_regulation ZNF652 TNF 18802666 1147896 Positive_regulation ZNF652 TNF 20577653 1911148 Positive_regulation ZNF652 TNF 21488180 3232344 Positive_regulation ZNF653 TNF 18802666 1147767 Positive_regulation ZNF653 TNF 20577653 1911019 Positive_regulation ZNF653 TNF 21488180 3232215 Positive_regulation ZNF654 TNF 18802666 1147779 Positive_regulation ZNF654 TNF 20577653 1911031 Positive_regulation ZNF654 TNF 21488180 3232227 Positive_regulation ZNF655 TNF 18802666 1147923 Positive_regulation ZNF655 TNF 20577653 1911175 Positive_regulation ZNF655 TNF 21488180 3232371 Positive_regulation ZNF658 TNF 18802666 1147768 Positive_regulation ZNF658 TNF 20577653 1911020 Positive_regulation ZNF658 TNF 21488180 3232216 Positive_regulation ZNF66 TNF 18802666 1147606 Positive_regulation ZNF66 TNF 20577653 1910858 Positive_regulation ZNF66 TNF 21488180 3232054 Positive_regulation ZNF660 TNF 18802666 1147823 Positive_regulation ZNF660 TNF 20577653 1911075 Positive_regulation ZNF660 TNF 21488180 3232271 Positive_regulation ZNF662 TNF 18802666 1147935 Positive_regulation ZNF662 TNF 20577653 1911187 Positive_regulation ZNF662 TNF 21488180 3232383 Positive_regulation ZNF663 TNF 18802666 1147773 Positive_regulation ZNF663 TNF 20577653 1911025 Positive_regulation ZNF663 TNF 21488180 3232221 Positive_regulation ZNF664 TNF 18802666 1147777 Positive_regulation ZNF664 TNF 20577653 1911029 Positive_regulation ZNF664 TNF 21488180 3232225 Positive_regulation ZNF665 TNF 18802666 1147789 Positive_regulation ZNF665 TNF 20577653 1911041 Positive_regulation ZNF665 TNF 21488180 3232237 Positive_regulation ZNF667 TNF 18802666 1147886 Positive_regulation ZNF667 TNF 20577653 1911138 Positive_regulation ZNF667 TNF 21488180 3232334 Positive_regulation ZNF668 TNF 18802666 1147783 Positive_regulation ZNF668 TNF 20577653 1911035 Positive_regulation ZNF668 TNF 21488180 3232231 Positive_regulation ZNF669 TNF 18802666 1147781 Positive_regulation ZNF669 TNF 20577653 1911033 Positive_regulation ZNF669 TNF 21488180 3232229 Positive_regulation ZNF670 TNF 18802666 1147861 Positive_regulation ZNF670 TNF 20577653 1911113 Positive_regulation ZNF670 TNF 21488180 3232309 Positive_regulation ZNF671 TNF 18802666 1147801 Positive_regulation ZNF671 TNF 20577653 1911053 Positive_regulation ZNF671 TNF 21488180 3232249 Positive_regulation ZNF672 TNF 18802666 1147799 Positive_regulation ZNF672 TNF 20577653 1911051 Positive_regulation ZNF672 TNF 21488180 3232247 Positive_regulation ZNF674 TNF 18802666 1147663 Positive_regulation ZNF674 TNF 20577653 1910915 Positive_regulation ZNF674 TNF 21488180 3232111 Positive_regulation ZNF675 TNF 18802666 1147922 Positive_regulation ZNF675 TNF 20577653 1911174 Positive_regulation ZNF675 TNF 21488180 3232370 Positive_regulation ZNF676 TNF 18802666 1147683 Positive_regulation ZNF676 TNF 20577653 1910935 Positive_regulation ZNF676 TNF 21488180 3232131 Positive_regulation ZNF677 TNF 18802666 1147883 Positive_regulation ZNF677 TNF 20577653 1911135 Positive_regulation ZNF677 TNF 21488180 3232331 Positive_regulation ZNF678 TNF 18802666 1147877 Positive_regulation ZNF678 TNF 20577653 1911129 Positive_regulation ZNF678 TNF 21488180 3232325 Positive_regulation ZNF679 TNF 18802666 1147876 Positive_regulation ZNF679 TNF 20577653 1911128 Positive_regulation ZNF679 TNF 21488180 3232324 Positive_regulation ZNF680 TNF 18802666 1147830 Positive_regulation ZNF680 TNF 20577653 1911082 Positive_regulation ZNF680 TNF 21488180 3232278 Positive_regulation ZNF681 TNF 18802666 1147812 Positive_regulation ZNF681 TNF 20577653 1911064 Positive_regulation ZNF681 TNF 21488180 3232260 Positive_regulation ZNF682 TNF 18802666 1147888 Positive_regulation ZNF682 TNF 20577653 1911140 Positive_regulation ZNF682 TNF 21488180 3232336 Positive_regulation ZNF683 TNF 18802666 1147872 Positive_regulation ZNF683 TNF 20577653 1911124 Positive_regulation ZNF683 TNF 21488180 3232320 Positive_regulation ZNF684 TNF 18802666 1147870 Positive_regulation ZNF684 TNF 20577653 1911122 Positive_regulation ZNF684 TNF 21488180 3232318 Positive_regulation ZNF687 TNF 18802666 1147901 Positive_regulation ZNF687 TNF 20577653 1911153 Positive_regulation ZNF687 TNF 21488180 3232349 Positive_regulation ZNF688 TNF 18802666 1147917 Positive_regulation ZNF688 TNF 20577653 1911169 Positive_regulation ZNF688 TNF 21488180 3232365 Positive_regulation ZNF689 TNF 18802666 1147766 Positive_regulation ZNF689 TNF 20577653 1911018 Positive_regulation ZNF689 TNF 21488180 3232214 Positive_regulation ZNF69 TNF 18802666 1147607 Positive_regulation ZNF69 TNF 20577653 1910859 Positive_regulation ZNF69 TNF 21488180 3232055 Positive_regulation ZNF691 TNF 18802666 1147853 Positive_regulation ZNF691 TNF 20577653 1911105 Positive_regulation ZNF691 TNF 21488180 3232301 Positive_regulation ZNF692 TNF 18802666 1147795 Positive_regulation ZNF692 TNF 20577653 1911047 Positive_regulation ZNF692 TNF 21488180 3232243 Positive_regulation ZNF695 TNF 18802666 1147930 Positive_regulation ZNF695 TNF 20577653 1911182 Positive_regulation ZNF695 TNF 21488180 3232378 Positive_regulation ZNF696 TNF 18802666 1147786 Positive_regulation ZNF696 TNF 20577653 1911038 Positive_regulation ZNF696 TNF 21488180 3232234 Positive_regulation ZNF697 TNF 18802666 1147936 Positive_regulation ZNF697 TNF 20577653 1911188 Positive_regulation ZNF697 TNF 21488180 3232384 Positive_regulation ZNF699 TNF 18802666 1147756 Positive_regulation ZNF699 TNF 20577653 1911008 Positive_regulation ZNF699 TNF 21488180 3232204 Positive_regulation ZNF7 TNF 18802666 1147608 Positive_regulation ZNF7 TNF 20577653 1910860 Positive_regulation ZNF7 TNF 21488180 3232056 Positive_regulation ZNF70 TNF 18802666 1147609 Positive_regulation ZNF70 TNF 20577653 1910861 Positive_regulation ZNF70 TNF 21488180 3232057 Positive_regulation ZNF700 TNF 18802666 1147770 Positive_regulation ZNF700 TNF 20577653 1911022 Positive_regulation ZNF700 TNF 21488180 3232218 Positive_regulation ZNF701 TNF 18802666 1147778 Positive_regulation ZNF701 TNF 20577653 1911030 Positive_regulation ZNF701 TNF 21488180 3232226 Positive_regulation ZNF703 CCND1 19330026 2124991 Positive_regulation ZNF703 CCND1 19330026 2124998 Positive_regulation ZNF703 CCND1 21328542 775887 Positive_regulation ZNF703 CCND1 21635707 467839 Positive_regulation ZNF703 TNF 18802666 1147788 Positive_regulation ZNF703 TNF 20577653 1911040 Positive_regulation ZNF703 TNF 21488180 3232236 Positive_regulation ZNF704 TNF 18802666 1147938 Positive_regulation ZNF704 TNF 20577653 1911190 Positive_regulation ZNF704 TNF 21488180 3232386 Positive_regulation ZNF706 TNF 18802666 1147759 Positive_regulation ZNF706 TNF 20577653 1911011 Positive_regulation ZNF706 TNF 21488180 3232207 Positive_regulation ZNF707 TNF 18802666 1147850 Positive_regulation ZNF707 TNF 20577653 1911102 Positive_regulation ZNF707 TNF 21488180 3232298 Positive_regulation ZNF708 TNF 18802666 1147519 Positive_regulation ZNF708 TNF 20577653 1910771 Positive_regulation ZNF708 TNF 21488180 3231967 Positive_regulation ZNF709 TNF 18802666 1147684 Positive_regulation ZNF709 TNF 20577653 1910936 Positive_regulation ZNF709 TNF 21488180 3232132 Positive_regulation ZNF71 TNF 18802666 1147610 Positive_regulation ZNF71 TNF 19712456 1696398 Positive_regulation ZNF71 TNF 20577653 1910862 Positive_regulation ZNF71 TNF 21488180 3232058 Positive_regulation ZNF710 TNF 18802666 1147774 Positive_regulation ZNF710 TNF 20577653 1911026 Positive_regulation ZNF710 TNF 21488180 3232222 Positive_regulation ZNF711 TNF 18802666 1147605 Positive_regulation ZNF711 TNF 20577653 1910857 Positive_regulation ZNF711 TNF 21488180 3232053 Positive_regulation ZNF713 TNF 18802666 1147720 Positive_regulation ZNF713 TNF 20577653 1910972 Positive_regulation ZNF713 TNF 21488180 3232168 Positive_regulation ZNF714 TNF 18802666 1147835 Positive_regulation ZNF714 TNF 20577653 1911087 Positive_regulation ZNF714 TNF 21488180 3232283 Positive_regulation ZNF716 TNF 18802666 1147939 Positive_regulation ZNF716 TNF 20577653 1911191 Positive_regulation ZNF716 TNF 21488180 3232387 Positive_regulation ZNF717 TNF 18802666 1147912 Positive_regulation ZNF717 TNF 20577653 1911164 Positive_regulation ZNF717 TNF 21488180 3232360 Positive_regulation ZNF718 TNF 18802666 1147828 Positive_regulation ZNF718 TNF 20577653 1911080 Positive_regulation ZNF718 TNF 21488180 3232276 Positive_regulation ZNF720 TNF 18802666 1147832 Positive_regulation ZNF720 TNF 20577653 1911084 Positive_regulation ZNF720 TNF 21488180 3232280 Positive_regulation ZNF721 TNF 18802666 1147911 Positive_regulation ZNF721 TNF 20577653 1911163 Positive_regulation ZNF721 TNF 21488180 3232359 Positive_regulation ZNF723 TNF 18802666 1147937 Positive_regulation ZNF723 TNF 20577653 1911189 Positive_regulation ZNF723 TNF 21488180 3232385 Positive_regulation ZNF726 TNF 18802666 1147940 Positive_regulation ZNF726 TNF 20577653 1911192 Positive_regulation ZNF726 TNF 21488180 3232388 Positive_regulation ZNF727 TNF 18802666 1147723 Positive_regulation ZNF727 TNF 20577653 1910975 Positive_regulation ZNF727 TNF 21488180 3232171 Positive_regulation ZNF728 TNF 18802666 1147941 Positive_regulation ZNF728 TNF 20577653 1911193 Positive_regulation ZNF728 TNF 21488180 3232389 Positive_regulation ZNF729 TNF 18802666 1147942 Positive_regulation ZNF729 TNF 20577653 1911194 Positive_regulation ZNF729 TNF 21488180 3232390 Positive_regulation ZNF73 TNF 18802666 1147611 Positive_regulation ZNF73 TNF 20577653 1910863 Positive_regulation ZNF73 TNF 21488180 3232059 Positive_regulation ZNF730 TNF 18802666 1147947 Positive_regulation ZNF730 TNF 20577653 1911199 Positive_regulation ZNF730 TNF 21488180 3232395 Positive_regulation ZNF732 TNF 18802666 1147969 Positive_regulation ZNF732 TNF 20577653 1911221 Positive_regulation ZNF732 TNF 21488180 3232417 Positive_regulation ZNF735 TNF 18802666 1147943 Positive_regulation ZNF735 TNF 20577653 1911195 Positive_regulation ZNF735 TNF 21488180 3232391 Positive_regulation ZNF736 TNF 18802666 1147944 Positive_regulation ZNF736 TNF 20577653 1911196 Positive_regulation ZNF736 TNF 21488180 3232392 Positive_regulation ZNF737 TNF 18802666 1147945 Positive_regulation ZNF737 TNF 20577653 1911197 Positive_regulation ZNF737 TNF 21488180 3232393 Positive_regulation ZNF738 TNF 18802666 1147946 Positive_regulation ZNF738 TNF 20577653 1911198 Positive_regulation ZNF738 TNF 21488180 3232394 Positive_regulation ZNF74 TNF 18802666 1147612 Positive_regulation ZNF74 TNF 20577653 1910864 Positive_regulation ZNF74 TNF 21488180 3232060 Positive_regulation ZNF740 TNF 18802666 1147844 Positive_regulation ZNF740 TNF 20577653 1911096 Positive_regulation ZNF740 TNF 21488180 3232292 Positive_regulation ZNF746 TNF 18802666 1147719 Positive_regulation ZNF746 TNF 20577653 1910971 Positive_regulation ZNF746 TNF 21488180 3232167 Positive_regulation ZNF747 TNF 18802666 1147867 Positive_regulation ZNF747 TNF 20577653 1911119 Positive_regulation ZNF747 TNF 21488180 3232315 Positive_regulation ZNF749 TNF 18802666 1147948 Positive_regulation ZNF749 TNF 20577653 1911200 Positive_regulation ZNF749 TNF 21488180 3232396 Positive_regulation ZNF750 TNF 18802666 1147785 Positive_regulation ZNF750 TNF 20577653 1911037 Positive_regulation ZNF750 TNF 21488180 3232233 Positive_regulation ZNF76 TNF 18802666 1147613 Positive_regulation ZNF76 TNF 20577653 1910865 Positive_regulation ZNF76 TNF 21488180 3232061 Positive_regulation ZNF761 TNF 18802666 1147725 Positive_regulation ZNF761 TNF 20577653 1910977 Positive_regulation ZNF761 TNF 21488180 3232173 Positive_regulation ZNF763 TNF 18802666 1147847 Positive_regulation ZNF763 TNF 20577653 1911099 Positive_regulation ZNF763 TNF 21488180 3232295 Positive_regulation ZNF764 TNF 18802666 1147864 Positive_regulation ZNF764 TNF 20577653 1911116 Positive_regulation ZNF764 TNF 21488180 3232312 Positive_regulation ZNF765 TNF 18802666 1147762 Positive_regulation ZNF765 TNF 20577653 1911014 Positive_regulation ZNF765 TNF 21488180 3232210 Positive_regulation ZNF766 TNF 18802666 1147857 Positive_regulation ZNF766 TNF 20577653 1911109 Positive_regulation ZNF766 TNF 21488180 3232305 Positive_regulation ZNF767 TNF 18802666 1147718 Positive_regulation ZNF767 TNF 20577653 1910970 Positive_regulation ZNF767 TNF 21488180 3232166 Positive_regulation ZNF768 TNF 18802666 1147800 Positive_regulation ZNF768 TNF 20577653 1911052 Positive_regulation ZNF768 TNF 21488180 3232248 Positive_regulation ZNF77 TNF 18802666 1147614 Positive_regulation ZNF77 TNF 20577653 1910866 Positive_regulation ZNF77 TNF 21488180 3232062 Positive_regulation ZNF770 TNF 18802666 1147796 Positive_regulation ZNF770 TNF 20577653 1911048 Positive_regulation ZNF770 TNF 21488180 3232244 Positive_regulation ZNF771 TNF 18802666 1147914 Positive_regulation ZNF771 TNF 20577653 1911166 Positive_regulation ZNF771 TNF 21488180 3232362 Positive_regulation ZNF772 TNF 18802666 1147950 Positive_regulation ZNF772 TNF 20577653 1911202 Positive_regulation ZNF772 TNF 21488180 3232398 Positive_regulation ZNF773 TNF 18802666 1147916 Positive_regulation ZNF773 TNF 20577653 1911168 Positive_regulation ZNF773 TNF 21488180 3232364 Positive_regulation ZNF774 TNF 18802666 1147951 Positive_regulation ZNF774 TNF 20577653 1911203 Positive_regulation ZNF774 TNF 21488180 3232399 Positive_regulation ZNF775 TNF 18802666 1147873 Positive_regulation ZNF775 TNF 20577653 1911125 Positive_regulation ZNF775 TNF 21488180 3232321 Positive_regulation ZNF776 TNF 18802666 1147827 Positive_regulation ZNF776 TNF 20577653 1911079 Positive_regulation ZNF776 TNF 21488180 3232275 Positive_regulation ZNF777 TNF 18802666 1147721 Positive_regulation ZNF777 TNF 20577653 1910973 Positive_regulation ZNF777 TNF 21488180 3232169 Positive_regulation ZNF778 TNF 18802666 1147813 Positive_regulation ZNF778 TNF 20577653 1911065 Positive_regulation ZNF778 TNF 21488180 3232261 Positive_regulation ZNF781 TNF 18802666 1147825 Positive_regulation ZNF781 TNF 20577653 1911077 Positive_regulation ZNF781 TNF 21488180 3232273 Positive_regulation ZNF782 TNF 18802666 1147952 Positive_regulation ZNF782 TNF 20577653 1911204 Positive_regulation ZNF782 TNF 21488180 3232400 Positive_regulation ZNF783 TNF 18802666 1147838 Positive_regulation ZNF783 TNF 20577653 1911090 Positive_regulation ZNF783 TNF 21488180 3232286 Positive_regulation ZNF784 TNF 18802666 1147953 Positive_regulation ZNF784 TNF 20577653 1911205 Positive_regulation ZNF784 TNF 21488180 3232401 Positive_regulation ZNF785 TNF 18802666 1147815 Positive_regulation ZNF785 TNF 20577653 1911067 Positive_regulation ZNF785 TNF 21488180 3232263 Positive_regulation ZNF786 TNF 18802666 1147717 Positive_regulation ZNF786 TNF 20577653 1910969 Positive_regulation ZNF786 TNF 21488180 3232165 Positive_regulation ZNF787 TNF 18802666 1147834 Positive_regulation ZNF787 TNF 20577653 1911086 Positive_regulation ZNF787 TNF 21488180 3232282 Positive_regulation ZNF788 TNF 18802666 1147954 Positive_regulation ZNF788 TNF 20577653 1911206 Positive_regulation ZNF788 TNF 21488180 3232402 Positive_regulation ZNF789 TNF 18802666 1147849 Positive_regulation ZNF789 TNF 20577653 1911101 Positive_regulation ZNF789 TNF 21488180 3232297 Positive_regulation ZNF79 TNF 18802666 1147615 Positive_regulation ZNF79 TNF 20577653 1910867 Positive_regulation ZNF79 TNF 21488180 3232063 Positive_regulation ZNF790 TNF 18802666 1147955 Positive_regulation ZNF790 TNF 20577653 1911207 Positive_regulation ZNF790 TNF 21488180 3232403 Positive_regulation ZNF791 TNF 18802666 1147829 Positive_regulation ZNF791 TNF 20577653 1911081 Positive_regulation ZNF791 TNF 21488180 3232277 Positive_regulation ZNF792 TNF 18802666 1147757 Positive_regulation ZNF792 TNF 20577653 1911009 Positive_regulation ZNF792 TNF 21488180 3232205 Positive_regulation ZNF793 TNF 18802666 1147956 Positive_regulation ZNF793 TNF 20577653 1911208 Positive_regulation ZNF793 TNF 21488180 3232404 Positive_regulation ZNF799 TNF 18802666 1147859 Positive_regulation ZNF799 TNF 20577653 1911111 Positive_regulation ZNF799 TNF 21488180 3232307 Positive_regulation ZNF8 TNF 18802666 1147616 Positive_regulation ZNF8 TNF 20577653 1910868 Positive_regulation ZNF8 TNF 21488180 3232064 Positive_regulation ZNF80 TNF 18802666 1147617 Positive_regulation ZNF80 TNF 20577653 1910869 Positive_regulation ZNF80 TNF 21488180 3232065 Positive_regulation ZNF800 TNF 18802666 1147840 Positive_regulation ZNF800 TNF 20577653 1911092 Positive_regulation ZNF800 TNF 21488180 3232288 Positive_regulation ZNF805 TNF 18802666 1147731 Positive_regulation ZNF805 TNF 20577653 1910983 Positive_regulation ZNF805 TNF 21488180 3232179 Positive_regulation ZNF806 TNF 18802666 1147957 Positive_regulation ZNF806 TNF 20577653 1911209 Positive_regulation ZNF806 TNF 21488180 3232405 Positive_regulation ZNF807 TNF 18802666 1147958 Positive_regulation ZNF807 TNF 20577653 1911210 Positive_regulation ZNF807 TNF 21488180 3232406 Positive_regulation ZNF808 TNF 18802666 1147959 Positive_regulation ZNF808 TNF 20577653 1911211 Positive_regulation ZNF808 TNF 21488180 3232407 Positive_regulation ZNF81 TNF 18802666 1147618 Positive_regulation ZNF81 TNF 20577653 1910870 Positive_regulation ZNF81 TNF 21488180 3232066 Positive_regulation ZNF812 TNF 18802666 1147960 Positive_regulation ZNF812 TNF 20577653 1911212 Positive_regulation ZNF812 TNF 21488180 3232408 Positive_regulation ZNF813 TNF 18802666 1147961 Positive_regulation ZNF813 TNF 20577653 1911213 Positive_regulation ZNF813 TNF 21488180 3232409 Positive_regulation ZNF814 TNF 18802666 1147962 Positive_regulation ZNF814 TNF 20577653 1911214 Positive_regulation ZNF814 TNF 21488180 3232410 Positive_regulation ZNF816 TNF 18802666 1147833 Positive_regulation ZNF816 TNF 20577653 1911085 Positive_regulation ZNF816 TNF 21488180 3232281 Positive_regulation ZNF821 TNF 18802666 1147854 Positive_regulation ZNF821 TNF 20577653 1911106 Positive_regulation ZNF821 TNF 21488180 3232302 Positive_regulation ZNF823 TNF 18802666 1147924 Positive_regulation ZNF823 TNF 20577653 1911176 Positive_regulation ZNF823 TNF 21488180 3232372 Positive_regulation ZNF827 TNF 18802666 1147836 Positive_regulation ZNF827 TNF 20577653 1911088 Positive_regulation ZNF827 TNF 21488180 3232284 Positive_regulation ZNF829 TNF 18802666 1147963 Positive_regulation ZNF829 TNF 20577653 1911215 Positive_regulation ZNF829 TNF 21488180 3232411 Positive_regulation ZNF83 TNF 18802666 1147619 Positive_regulation ZNF83 TNF 20577653 1910871 Positive_regulation ZNF83 TNF 21488180 3232067 Positive_regulation ZNF830 TNF 18802666 1147865 Positive_regulation ZNF830 TNF 20577653 1911117 Positive_regulation ZNF830 TNF 21488180 3232313 Positive_regulation ZNF831 TNF 18802666 1147653 Positive_regulation ZNF831 TNF 20577653 1910905 Positive_regulation ZNF831 TNF 21488180 3232101 Positive_regulation ZNF835 TNF 18802666 1147964 Positive_regulation ZNF835 TNF 20577653 1911216 Positive_regulation ZNF835 TNF 21488180 3232412 Positive_regulation ZNF836 TNF 18802666 1147965 Positive_regulation ZNF836 TNF 20577653 1911217 Positive_regulation ZNF836 TNF 21488180 3232413 Positive_regulation ZNF837 TNF 18802666 1147765 Positive_regulation ZNF837 TNF 20577653 1911017 Positive_regulation ZNF837 TNF 21488180 3232213 Positive_regulation ZNF839 TNF 18802666 1147682 Positive_regulation ZNF839 TNF 20577653 1910934 Positive_regulation ZNF839 TNF 21488180 3232130 Positive_regulation ZNF84 TNF 18802666 1147620 Positive_regulation ZNF84 TNF 20577653 1910872 Positive_regulation ZNF84 TNF 21488180 3232068 Positive_regulation ZNF840 TNF 18802666 1147966 Positive_regulation ZNF840 TNF 20577653 1911218 Positive_regulation ZNF840 TNF 21488180 3232414 Positive_regulation ZNF841 TNF 18802666 1147846 Positive_regulation ZNF841 TNF 20577653 1911098 Positive_regulation ZNF841 TNF 21488180 3232294 Positive_regulation ZNF843 TNF 18802666 1147882 Positive_regulation ZNF843 TNF 20577653 1911134 Positive_regulation ZNF843 TNF 21488180 3232330 Positive_regulation ZNF844 TNF 18802666 1147792 Positive_regulation ZNF844 TNF 20577653 1911044 Positive_regulation ZNF844 TNF 21488180 3232240 Positive_regulation ZNF845 TNF 18802666 1147764 Positive_regulation ZNF845 TNF 20577653 1911016 Positive_regulation ZNF845 TNF 21488180 3232212 Positive_regulation ZNF846 TNF 18802666 1147839 Positive_regulation ZNF846 TNF 20577653 1911091 Positive_regulation ZNF846 TNF 21488180 3232287 Positive_regulation ZNF85 TNF 18802666 1147621 Positive_regulation ZNF85 TNF 20577653 1910873 Positive_regulation ZNF85 TNF 21488180 3232069 Positive_regulation ZNF850 TNF 18802666 1147852 Positive_regulation ZNF850 TNF 20577653 1911104 Positive_regulation ZNF850 TNF 21488180 3232300 Positive_regulation ZNF852 TNF 18802666 1147848 Positive_regulation ZNF852 TNF 20577653 1911100 Positive_regulation ZNF852 TNF 21488180 3232296 Positive_regulation ZNF853 TNF 18802666 1147716 Positive_regulation ZNF853 TNF 20577653 1910968 Positive_regulation ZNF853 TNF 21488180 3232164 Positive_regulation ZNF860 TNF 18802666 1147967 Positive_regulation ZNF860 TNF 20577653 1911219 Positive_regulation ZNF860 TNF 21488180 3232415 Positive_regulation ZNF862 TNF 18802666 1147968 Positive_regulation ZNF862 TNF 20577653 1911220 Positive_regulation ZNF862 TNF 21488180 3232416 Positive_regulation ZNF865 TNF 18802666 1147974 Positive_regulation ZNF865 TNF 20577653 1911226 Positive_regulation ZNF865 TNF 21488180 3232422 Positive_regulation ZNF878 TNF 18802666 1147970 Positive_regulation ZNF878 TNF 20577653 1911222 Positive_regulation ZNF878 TNF 21488180 3232418 Positive_regulation ZNF879 TNF 18802666 1147972 Positive_regulation ZNF879 TNF 20577653 1911224 Positive_regulation ZNF879 TNF 21488180 3232420 Positive_regulation ZNF880 TNF 18802666 1147971 Positive_regulation ZNF880 TNF 20577653 1911223 Positive_regulation ZNF880 TNF 21488180 3232419 Positive_regulation ZNF883 TNF 18802666 1147842 Positive_regulation ZNF883 TNF 20577653 1911094 Positive_regulation ZNF883 TNF 21488180 3232290 Positive_regulation ZNF888 TNF 18802666 1147973 Positive_regulation ZNF888 TNF 20577653 1911225 Positive_regulation ZNF888 TNF 21488180 3232421 Positive_regulation ZNF891 TNF 18802666 1147975 Positive_regulation ZNF891 TNF 20577653 1911227 Positive_regulation ZNF891 TNF 21488180 3232423 Positive_regulation ZNF90 TNF 18802666 1147622 Positive_regulation ZNF90 TNF 20577653 1910874 Positive_regulation ZNF90 TNF 21488180 3232070 Positive_regulation ZNF91 TNF 18802666 1147623 Positive_regulation ZNF91 TNF 20577653 1910875 Positive_regulation ZNF91 TNF 21488180 3232071 Positive_regulation ZNF92 TNF 18802666 1147624 Positive_regulation ZNF92 TNF 20577653 1910876 Positive_regulation ZNF92 TNF 21488180 3232072 Positive_regulation ZNF93 TNF 18802666 1147625 Positive_regulation ZNF93 TNF 20577653 1910877 Positive_regulation ZNF93 TNF 21488180 3232073 Positive_regulation ZNF98 TNF 18802666 1147626 Positive_regulation ZNF98 TNF 20577653 1910878 Positive_regulation ZNF98 TNF 21488180 3232074 Positive_regulation ZNF99 TNF 18802666 1147627 Positive_regulation ZNF99 TNF 20577653 1910879 Positive_regulation ZNF99 TNF 21488180 3232075 Positive_regulation ZSWIM2 F2R 23242217 1928917 Positive_regulation ZYX EPHB2 22456508 1801502 Positive_regulation ZYX EPHB2 22456508 1801504 Regulation ABCA1 ARSA 20137092 1722984 Regulation ABCA1 TNF 23914732 230407 Regulation ABCA1 TNF 23914732 230409 Regulation ABCA12 NF1 22776759 2180436 Regulation ABCA12 TLR3 23353987 1632005 Regulation ABCA4 CLCN1 21423376 955165 Regulation ABCA4 COASY 21293470 12479 Regulation ABCA4 IL1A 19091115 1897134 Regulation ABCB1 ABCG2 22545122 2623438 Regulation ABCB1 ABCG2 24129235 442059 Regulation ABCB1 EPHB2 23799854 440999 Regulation ABCB1 MX2 10070877 414020 Regulation ABCB1 MX2 10070877 414021 Regulation ABCB1 NES 24286324 222177 Regulation ABCB1 PLAU 19603017 432439 Regulation ABCB1 PLAU 19603017 432446 Regulation ABCB11 ALOX5 25444678 590477 Regulation ABCC1 EPHB2 22787275 1805509 Regulation ABCC1 EPHB2 22787275 1805512 Regulation ABCC1 MAP2K6 23320839 482764 Regulation ABCC1 PLAU 19603017 432448 Regulation ABCC1 RNASE1 16585272 1328711 Regulation ABCC1 RNASE1 16585272 1328808 Regulation ABCC1 RNASE7 16585272 1328720 Regulation ABCC1 RNASE7 16585272 1328816 Regulation ABCC11 ATM 22837662 1096292 Regulation ABCD1 TLR7 20827314 979344 Regulation ABCG1 TNF 23914732 230408 Regulation ABCG2 ABCA3 21526180 2513893 Regulation ABCG2 ABL1 23259070 1719138 Regulation ABCG2 AHR 25246735 1636199 Regulation ABCG2 AHR 25246735 1636201 Regulation ABCG2 AKT1 21943250 734166 Regulation ABCG2 AKT1 24281174 501836 Regulation ABCG2 AKT2 21943250 734167 Regulation ABCG2 AKT2 24281174 501837 Regulation ABCG2 AKT3 21943250 734168 Regulation ABCG2 AKT3 24281174 501838 Regulation ABCG2 BCR 23259070 1719137 Regulation ABCG2 BCRP1 24523596 2249885 Regulation ABCG2 BCRP2 24523596 2249881 Regulation ABCG2 BCRP3 24523596 2249882 Regulation ABCG2 BCRP4 24523596 2249883 Regulation ABCG2 BCRP5 24523596 2249884 Regulation ABCG2 BCRP6 24523596 2249886 Regulation ABCG2 BCRP7 24523596 2249887 Regulation ABCG2 BCRP8 24523596 2249888 Regulation ABCG2 BCRP9 24523596 2249889 Regulation ABCG2 CAV1 22952907 2685005 Regulation ABCG2 CD44 24124770 270076 Regulation ABCG2 CSF3 22252524 3204990 Regulation ABCG2 FOXM1 25213081 475619 Regulation ABCG2 FOXM1 25213081 475622 Regulation ABCG2 GABPA 24040073 2845432 Regulation ABCG2 KITLG 22252524 3204991 Regulation ABCG2 MAPK1 23226356 2724325 Regulation ABCG2 MAPK10 23226356 2724326 Regulation ABCG2 MAPK11 23226356 2724327 Regulation ABCG2 MAPK12 23226356 2724328 Regulation ABCG2 MAPK13 23226356 2724329 Regulation ABCG2 MAPK14 23226356 2724330 Regulation ABCG2 MAPK15 23226356 2724324 Regulation ABCG2 MAPK3 23226356 2724331 Regulation ABCG2 MAPK4 23226356 2724332 Regulation ABCG2 MAPK6 23226356 2724333 Regulation ABCG2 MAPK7 23226356 2724334 Regulation ABCG2 MAPK8 22870247 2672092 Regulation ABCG2 MAPK8 23226356 2724335 Regulation ABCG2 MAPK9 23226356 2724336 Regulation ABCG2 MYLIP 22453125 438421 Regulation ABCG2 MYLIP 22453125 438422 Regulation ABCG2 MYLIP 24358977 1232719 Regulation ABCG2 MYLIP 24358977 1232720 Regulation ABCG2 PIK3CA 21943250 734169 Regulation ABCG2 PIK3R1 21943250 734170 Regulation ABCG2 PPARA 18288266 3071797 Regulation ABCG2 PTEN 21943250 734171 Regulation ABCG2 SALL4 21526180 2513890 Regulation ABCG2 SALL4 21526180 2513891 Regulation ABCG2 SALL4 21526180 2513892 Regulation ABCG2 SALL4 21526180 2513901 Regulation ABCG2 SALL4 21526180 2513907 Regulation ABCG2 SALL4 21526180 2513908 Regulation ABCG2 SPP1 23935934 2828593 Regulation ABCG2 USP1 21981826 333872 Regulation ABCG2 USP10 21981826 333873 Regulation ABCG2 USP11 21981826 333874 Regulation ABCG2 USP12 21981826 333917 Regulation ABCG2 USP13 21981826 333875 Regulation ABCG2 USP14 21981826 333876 Regulation ABCG2 USP15 21981826 333877 Regulation ABCG2 USP16 21981826 333878 Regulation ABCG2 USP18 21981826 333879 Regulation ABCG2 USP19 21981826 333880 Regulation ABCG2 USP2 21981826 333881 Regulation ABCG2 USP20 21981826 333882 Regulation ABCG2 USP21 21981826 333883 Regulation ABCG2 USP22 21981826 333884 Regulation ABCG2 USP24 21981826 333885 Regulation ABCG2 USP25 21981826 333886 Regulation ABCG2 USP26 21981826 333894 Regulation ABCG2 USP28 21981826 333887 Regulation ABCG2 USP29 21981826 333896 Regulation ABCG2 USP3 21981826 333888 Regulation ABCG2 USP30 21981826 333904 Regulation ABCG2 USP31 21981826 333899 Regulation ABCG2 USP32 21981826 333897 Regulation ABCG2 USP33 21981826 333898 Regulation ABCG2 USP34 21981826 333905 Regulation ABCG2 USP35 21981826 333900 Regulation ABCG2 USP36 21981826 333901 Regulation ABCG2 USP37 21981826 333902 Regulation ABCG2 USP38 21981826 333906 Regulation ABCG2 USP39 21981826 333910 Regulation ABCG2 USP4 21981826 333889 Regulation ABCG2 USP40 21981826 333908 Regulation ABCG2 USP41 21981826 333909 Regulation ABCG2 USP42 21981826 333907 Regulation ABCG2 USP43 21981826 333911 Regulation ABCG2 USP44 21981826 333903 Regulation ABCG2 USP45 21981826 333916 Regulation ABCG2 USP46 21981826 333912 Regulation ABCG2 USP47 21981826 333913 Regulation ABCG2 USP48 21981826 333895 Regulation ABCG2 USP49 21981826 333914 Regulation ABCG2 USP5 21981826 333890 Regulation ABCG2 USP50 21981826 333915 Regulation ABCG2 USP51 21981826 333918 Regulation ABCG2 USP53 21981826 333920 Regulation ABCG2 USP54 21981826 333919 Regulation ABCG2 USP6 21981826 333891 Regulation ABCG2 USP7 21981826 333892 Regulation ABCG2 USP8 21981826 333893 Regulation ABI1 LIPG 21831845 1500638 Regulation ABI1 TNF 22808230 2665192 Regulation ABL1 PECAM1 23233201 1141356 Regulation ABL1 PECAM1 23233201 1141373 Regulation ABO FUT4 22157667 1734736 Regulation ABO FUT4 22157667 1734747 Regulation ACACA EPHB2 18651976 1897063 Regulation ACAD8 EPHB2 24045785 3137208 Regulation ACAN EPHB2 19144181 112464 Regulation ACAN MAP2K6 19144181 112470 Regulation ACAN MMP28 12718749 99803 Regulation ACAN MMP7 12718749 99818 Regulation ACAN TNF 15642133 102075 Regulation ACAN TNF 15642133 102079 Regulation ACAN TNF 19435506 113283 Regulation ACD DAPK1 16476779 1327883 Regulation ACD ITGB2 17692468 157364 Regulation ACE EPHB2 24330074 1482220 Regulation ACE UCA1 24876127 758401 Regulation ACE2 FOXO1 21689484 404986 Regulation ACE2 MMP28 24454948 2910487 Regulation ACE2 MMP7 24454948 2910502 Regulation ACKR3 NR2F1 24906407 273670 Regulation ACKR3 TLR7 22745793 2656543 Regulation ACKR3 TNF 25084358 2994451 Regulation ACKR3 TNF 25084358 2994453 Regulation ACR RIC3 23950710 3063482 Regulation ACR RIC3 23950710 3063484 Regulation ACR TNF 21437062 629872 Regulation ACSM3 NNMT 23455543 1931966 Regulation ACSS1 INS 22275878 2328862 Regulation ACSS1 INS 22275878 2328878 Regulation ACSS1 INS 22275878 2328884 Regulation ACSS1 INS 22275878 2328890 Regulation ACSS1 INS 22275878 2328896 Regulation ACSS1 INS 22275878 2328902 Regulation ACSS1 SIRT3 23888142 858662 Regulation ACSS2 IL1B 14668096 1739210 Regulation ACTL6A EPHB2 24811485 2190646 Regulation ACTN4 RINL 22291991 2591596 Regulation ADAM10 EPHB2 24205136 2875493 Regulation ADAM10 MMP7 18478055 2388501 Regulation ADAM10 S100A7 19159013 2404520 Regulation ADAM10 S100A7 19159013 2404523 Regulation ADAM10 TNF 24520307 2167705 Regulation ADAM11 TLR7 19703986 1556022 Regulation ADAM11 TLR7 21912648 2552543 Regulation ADAM11 TLR7 24098110 3064243 Regulation ADAM11 TNF 22953039 2233619 Regulation ADAM15 TNF 16277668 104595 Regulation ADAM15 TNF 16277668 104597 Regulation ADAM15 TNF 16277668 104606 Regulation ADAM17 EPHB2 21386996 2506131 Regulation ADAM17 MAP2K6 20034375 1676618 Regulation ADAM17 MMP28 25414771 206546 Regulation ADAM17 MMP28 25414771 206612 Regulation ADAM17 MMP7 25414771 206561 Regulation ADAM17 MMP7 25414771 206627 Regulation ADAMTS1 ADM 24623968 1916797 Regulation ADAMTS1 ADM 24623968 1916798 Regulation ADAMTS1 ANKH 22206702 124524 Regulation ADAMTS1 CRK 20619343 1731737 Regulation ADAMTS1 EAF2 24260246 2883047 Regulation ADAMTS1 EAF2 24260246 2883048 Regulation ADAMTS1 EAF2 24260246 2883052 Regulation ADAMTS1 FBLN1 19412524 2308792 Regulation ADAMTS1 IL17A 23977238 2839386 Regulation ADAMTS1 IL1A 16919164 106561 Regulation ADAMTS1 IL1A 20619343 1731713 Regulation ADAMTS1 IL1A 20619343 1731749 Regulation ADAMTS1 IL1A 25228841 1712827 Regulation ADAMTS1 IL1RN 17760968 108885 Regulation ADAMTS1 IL1RN 17760968 108886 Regulation ADAMTS1 MAPK1 20619343 1731714 Regulation ADAMTS1 MAPK10 20619343 1731715 Regulation ADAMTS1 MAPK11 20619343 1731716 Regulation ADAMTS1 MAPK12 20619343 1731717 Regulation ADAMTS1 MAPK13 20619343 1731718 Regulation ADAMTS1 MAPK14 20619343 1731719 Regulation ADAMTS1 MAPK15 20619343 1731712 Regulation ADAMTS1 MAPK3 20619343 1731720 Regulation ADAMTS1 MAPK4 20619343 1731721 Regulation ADAMTS1 MAPK6 20619343 1731722 Regulation ADAMTS1 MAPK7 20619343 1731723 Regulation ADAMTS1 MAPK8 20619343 1731724 Regulation ADAMTS1 MAPK9 20619343 1731725 Regulation ADAMTS1 OSM 16919164 106562 Regulation ADAMTS1 PGF 20840749 257312 Regulation ADAMTS1 PGF 20840749 257315 Regulation ADAMTS1 PGF 20840749 257318 Regulation ADAMTS1 PGF 20840749 257321 Regulation ADAMTS1 SULT2A1 24275094 1054250 Regulation ADAMTS1 TNF 24176075 1667232 Regulation ADAMTS4 MAP2K6 18662930 90771 Regulation ADAMTS4 MAP2K6 18662930 90805 Regulation ADAMTS4 TNF 24176075 1667233 Regulation ADAMTS4 TNF 24595230 2930865 Regulation ADAMTS4 TNF 25606593 133997 Regulation ADAMTS5 ADAMTS1 23859810 694903 Regulation ADAMTS8 ADAMTS1 23947778 1481436 Regulation ADAMTS9 ADAMTS1 23947778 1481435 Regulation ADCY1 CABP4 6985613 1434369 Regulation ADCY1 CABP4 6989840 1434419 Regulation ADCY10 CABP4 6985613 1434364 Regulation ADCY10 CABP4 6989840 1434414 Regulation ADCY2 CABP4 6985613 1434374 Regulation ADCY2 CABP4 6989840 1434424 Regulation ADCY3 CABP4 6985613 1434379 Regulation ADCY3 CABP4 6989840 1434429 Regulation ADCY4 CABP4 6985613 1434384 Regulation ADCY4 CABP4 6989840 1434434 Regulation ADCY5 CABP4 6985613 1434389 Regulation ADCY5 CABP4 6989840 1434439 Regulation ADCY6 CABP4 6985613 1434394 Regulation ADCY6 CABP4 6989840 1434444 Regulation ADCY7 CABP4 6985613 1434399 Regulation ADCY7 CABP4 6989840 1434449 Regulation ADCY8 CABP4 6985613 1434404 Regulation ADCY8 CABP4 6989840 1434454 Regulation ADCY9 CABP4 6985613 1434409 Regulation ADCY9 CABP4 6989840 1434459 Regulation ADCYAP1 EPHB2 20062533 2436728 Regulation ADH4 ADH1C 20617019 1075648 Regulation ADH4 ADH1C 20617019 1075666 Regulation ADH5 ADH1C 20617019 1075650 Regulation ADH5 ADH1C 20617019 1075668 Regulation ADH6 ADH1C 20617019 1075652 Regulation ADH6 ADH1C 20617019 1075670 Regulation ADH7 ADH1C 20617019 1075654 Regulation ADH7 ADH1C 20617019 1075672 Regulation ADIPOQ PGC 24086538 2854562 Regulation ADIPOQ TNF 21274300 1492163 Regulation ADIPOQ TNF 22272381 1082520 Regulation ADIPOQ TNF 22293775 1886012 Regulation ADIPOQ TNF 22440821 91015 Regulation ADIPOQ TNF 22440821 91016 Regulation ADIPOQ TNF 22509348 2618752 Regulation ADIPOQ TNF 23383064 2747759 Regulation ADIPOQ TNF 24563869 1495685 Regulation ADIPOQ TNF 24886466 3102475 Regulation ADIPOR1 FOXO1 23349663 2742812 Regulation ADM MMP7 22359542 2597584 Regulation ADM TNF 23918941 1407106 Regulation ADM TNF 23918941 1407107 Regulation ADO NT5E 18404494 3089112 Regulation ADRB1 NGFR 23593219 2780366 Regulation ADRB2 EZH2 21532618 2139353 Regulation ADRB2 GPRC5B 18442421 1043607 Regulation ADRB2 LEP 23936460 2831042 Regulation ADRBK1 CAPN8 24265619 962843 Regulation ADRBK1 EPHB2 22447027 1956887 Regulation ADRBK1 MAP2K6 24597858 1650562 Regulation ADRBK1 MIP 24465168 1085054 Regulation AFP TCN1 20087354 434444 Regulation AFP TCN1 20087354 434445 Regulation AFP TCN1 20087354 434485 Regulation AFP TCN1 20087354 434495 Regulation AGAP3 TNF 23493728 1624172 Regulation AGR2 AR 23663520 473304 Regulation AGR2 CARD11 23129749 1569852 Regulation AGR2 CDKN1A 8228821 1594592 Regulation AGR2 CTD 25364455 2170117 Regulation AGR2 ERBB2 20840765 257332 Regulation AGR2 ERN1 24914235 1419734 Regulation AGR2 PPP1R12A 22641346 1397916 Regulation AGR2 RASA1 8228821 1594593 Regulation AGR2 SHH 23213390 168086 Regulation AGR2 SMAD4 22945649 2148375 Regulation AGR2 SMAD4 22945649 2148378 Regulation AGR2 SPDEF 23650437 1572117 Regulation AGRP FOXO1 17684549 2377530 Regulation AGRP FOXO1 23462798 733743 Regulation AGRP FOXO1 23462798 733744 Regulation AGRP FOXO1 23462798 733754 Regulation AGRP FOXO1 23579596 937983 Regulation AGRP FOXO1 23579596 938050 Regulation AGRP FOXO1 24567900 1887702 Regulation AGRP FOXO1 25610880 1496875 Regulation AGRP FOXO1 25610880 1496877 Regulation AGT TNF 22500179 1143845 Regulation AGTR1 FOXA1 18288266 3071789 Regulation AGTR1 IL1B 22642771 1662984 Regulation AGXT TNF 23251471 2728665 Regulation AHR SELL 21437035 1162383 Regulation AHR SPON2 21684833 794398 Regulation AHR SPON2 21684833 794399 Regulation AHR TNF 22110376 1058212 Regulation AHR TNF 23587290 2233531 Regulation AHSA1 ANGPT1 25329960 3016924 Regulation AHSA1 FAS 16818723 1330945 Regulation AHSA1 MAP2K6 20955562 120581 Regulation AHSA1 MIP 17233909 351820 Regulation AHSA1 TLR7 20832340 1040219 Regulation AHSA1 TLR7 25076949 913600 Regulation AHSA1 TNF 15175101 523670 Regulation AICDA FOXO1 18978794 1951893 Regulation AKAP13 HBEGF 22873932 532989 Regulation AKR1B1 TNF 25126080 965769 Regulation AKR1C1 CCND1 24848372 2972407 Regulation AKR1C3 CCND1 24848372 2972408 Regulation AKT1 ABCG2 24281174 501830 Regulation AKT1 ANGPT1 22454630 832638 Regulation AKT1 ANGPT1 25329960 3016927 Regulation AKT1 ANGPT1 25329960 3017042 Regulation AKT1 ARSA 19966835 8432 Regulation AKT1 BPI 22545124 2623471 Regulation AKT1 CCND1 21931533 2277084 Regulation AKT1 CCND1 22481935 1673572 Regulation AKT1 CCND1 23300578 2733858 Regulation AKT1 CCND1 23533654 2771113 Regulation AKT1 CCND1 24690900 2947239 Regulation AKT1 CCND1 24858012 2973330 Regulation AKT1 CD14 20011115 3045857 Regulation AKT1 CD22 25101192 3151869 Regulation AKT1 CEACAM6 25398131 3027602 Regulation AKT1 CHI3L1 19414556 1554755 Regulation AKT1 EFNB1 21795402 1793154 Regulation AKT1 EFNB1 21795402 1793221 Regulation AKT1 EPHB2 19255520 1704032 Regulation AKT1 EPHB2 21559368 2518978 Regulation AKT1 EPHB2 21699731 1862569 Regulation AKT1 EPHB2 21762482 387013 Regulation AKT1 EPHB2 22312244 1094824 Regulation AKT1 EPHB2 22649371 874884 Regulation AKT1 EPHB2 22967907 1506589 Regulation AKT1 EPHB2 23531532 1103295 Regulation AKT1 EPHB2 23554919 2773926 Regulation AKT1 EPHB2 23554919 2773998 Regulation AKT1 F2R 23236426 2726350 Regulation AKT1 FAS 21713032 2276550 Regulation AKT1 FHL1 24952875 274072 Regulation AKT1 FOXO1 20375467 27018 Regulation AKT1 FOXO1 20398329 465408 Regulation AKT1 FOXO1 21479203 2511162 Regulation AKT1 FOXO1 23786484 33253 Regulation AKT1 FOXO1 24162775 1959296 Regulation AKT1 FOXO1 24740015 2954346 Regulation AKT1 FOXO1 25400915 1037014 Regulation AKT1 GAB3 23805312 2808429 Regulation AKT1 HBEGF 19470173 1503702 Regulation AKT1 IFI27 24858012 2973331 Regulation AKT1 INPP4B 21487159 2175790 Regulation AKT1 INPP4B 22895072 478784 Regulation AKT1 INPP4B 22895072 478799 Regulation AKT1 INPP4B 24500884 492412 Regulation AKT1 KANK4 18458160 1351925 Regulation AKT1 KANK4 18458160 1352017 Regulation AKT1 KANK4 18458160 1352057 Regulation AKT1 MAP2K6 16103225 1323220 Regulation AKT1 MAP2K6 17088902 428259 Regulation AKT1 MAP2K6 18598360 480528 Regulation AKT1 MAP2K6 18729301 3231408 Regulation AKT1 MAP2K6 19917087 1676366 Regulation AKT1 MAP2K6 19917087 1676367 Regulation AKT1 MAP2K6 21762482 387019 Regulation AKT1 MAP2K6 22348085 2596784 Regulation AKT1 MAP2K6 22649371 874890 Regulation AKT1 MAP2K6 22649371 874974 Regulation AKT1 MAP2K6 22909302 138122 Regulation AKT1 MAP2K6 23049945 2699893 Regulation AKT1 MAP2K6 23112573 1915197 Regulation AKT1 MAP2K6 23531532 1103303 Regulation AKT1 MAP2K6 24475138 2914901 Regulation AKT1 MAP2K6 24970815 2194094 Regulation AKT1 MAP2K6 24970815 2194148 Regulation AKT1 NGFR 22880054 2673827 Regulation AKT1 NGFR 22880054 2673895 Regulation AKT1 RCAN1 19124655 1553366 Regulation AKT1 RGS2 25309327 871491 Regulation AKT1 SELL 23183047 1570176 Regulation AKT1 SPHK1 19956567 2432078 Regulation AKT1 SPHK1 21625639 2525223 Regulation AKT1 SPHK1 22961081 724498 Regulation AKT1 SYNM 22337773 1800672 Regulation AKT1 TCN1 20489726 546938 Regulation AKT1 TCN1 20489726 547044 Regulation AKT1 THSD7A 22194972 2583577 Regulation AKT1 TLR7 24367261 3065438 Regulation AKT1 TLR7 24740015 2954196 Regulation AKT1 TLR7 24740015 2954197 Regulation AKT1 TM4SF19 25344917 2206246 Regulation AKT1 TNF 11238593 1519021 Regulation AKT1 TNF 15841081 425879 Regulation AKT1 TNF 17208518 3203988 Regulation AKT1 TNF 18443205 705814 Regulation AKT1 TNF 21949832 2556713 Regulation AKT1 TNF 22973314 1068927 Regulation AKT1 TNF 23800251 1627187 Regulation AKT1 TNF 23800251 1627188 Regulation AKT1 TNF 23800251 1627189 Regulation AKT1 TNF 23800251 1627190 Regulation AKT1 TNF 25162582 3002932 Regulation AKT1 TNF 25352752 1917456 Regulation AKT1 TNF 25352752 1917480 Regulation AKT1 TNFSF10 20661217 2133113 Regulation AKT1 TNFSF10 25277183 2203061 Regulation AKT1 TP63 19517019 2419058 Regulation AKT1S1 EPHB2 23431403 2755374 Regulation AKT2 ABCG2 24281174 501831 Regulation AKT2 ANGPT1 22454630 832639 Regulation AKT2 ANGPT1 25329960 3016930 Regulation AKT2 ANGPT1 25329960 3017044 Regulation AKT2 ARSA 19966835 8433 Regulation AKT2 BPI 22545124 2623472 Regulation AKT2 CCND1 21931533 2277085 Regulation AKT2 CCND1 22481935 1673574 Regulation AKT2 CCND1 23300578 2733862 Regulation AKT2 CCND1 23533654 2771115 Regulation AKT2 CCND1 24690900 2947240 Regulation AKT2 CCND1 24858012 2973332 Regulation AKT2 CD14 20011115 3045858 Regulation AKT2 CD22 25101192 3151872 Regulation AKT2 CEACAM6 25398131 3027603 Regulation AKT2 CHI3L1 19414556 1554756 Regulation AKT2 EFNB1 21795402 1793156 Regulation AKT2 EFNB1 21795402 1793222 Regulation AKT2 EPHB2 19255520 1704033 Regulation AKT2 EPHB2 21559368 2518992 Regulation AKT2 EPHB2 21699731 1862570 Regulation AKT2 EPHB2 21762482 387021 Regulation AKT2 EPHB2 22312244 1094826 Regulation AKT2 EPHB2 22649371 874893 Regulation AKT2 EPHB2 22967907 1506590 Regulation AKT2 EPHB2 23531532 1103307 Regulation AKT2 EPHB2 23554919 2773940 Regulation AKT2 EPHB2 23554919 2774003 Regulation AKT2 F2R 23236426 2726351 Regulation AKT2 FAS 21713032 2276553 Regulation AKT2 FHL1 24952875 274073 Regulation AKT2 FOXO1 20375467 27022 Regulation AKT2 FOXO1 20398329 465412 Regulation AKT2 FOXO1 21479203 2511164 Regulation AKT2 FOXO1 24162775 1959297 Regulation AKT2 FOXO1 24740015 2954347 Regulation AKT2 FOXO1 25400915 1037018 Regulation AKT2 GAB3 23805312 2808433 Regulation AKT2 HBEGF 19470173 1503703 Regulation AKT2 IFI27 24858012 2973333 Regulation AKT2 INPP4B 21487159 2175791 Regulation AKT2 INPP4B 22895072 478785 Regulation AKT2 INPP4B 22895072 478800 Regulation AKT2 INPP4B 24500884 492413 Regulation AKT2 KANK4 18458160 1351931 Regulation AKT2 KANK4 18458160 1352021 Regulation AKT2 KANK4 18458160 1352061 Regulation AKT2 MAP2K6 16103225 1323227 Regulation AKT2 MAP2K6 17088902 428268 Regulation AKT2 MAP2K6 18598360 480535 Regulation AKT2 MAP2K6 18729301 3231417 Regulation AKT2 MAP2K6 19917087 1676400 Regulation AKT2 MAP2K6 19917087 1676401 Regulation AKT2 MAP2K6 21762482 387027 Regulation AKT2 MAP2K6 22348085 2596791 Regulation AKT2 MAP2K6 22649371 874899 Regulation AKT2 MAP2K6 22649371 874981 Regulation AKT2 MAP2K6 22909302 138131 Regulation AKT2 MAP2K6 23049945 2699902 Regulation AKT2 MAP2K6 23112573 1915206 Regulation AKT2 MAP2K6 23531532 1103315 Regulation AKT2 MAP2K6 24475138 2914908 Regulation AKT2 MAP2K6 24970815 2194101 Regulation AKT2 MAP2K6 24970815 2194155 Regulation AKT2 NGFR 22880054 2673829 Regulation AKT2 NGFR 22880054 2673897 Regulation AKT2 RCAN1 19124655 1553367 Regulation AKT2 RGS2 25309327 871492 Regulation AKT2 SELL 23183047 1570182 Regulation AKT2 SPHK1 19956567 2432079 Regulation AKT2 SPHK1 21625639 2525224 Regulation AKT2 SPHK1 22961081 724499 Regulation AKT2 SYNM 22337773 1800673 Regulation AKT2 TCN1 20489726 546940 Regulation AKT2 TCN1 20489726 547046 Regulation AKT2 THSD7A 22194972 2583578 Regulation AKT2 TLR7 24367261 3065448 Regulation AKT2 TLR7 24740015 2954216 Regulation AKT2 TLR7 24740015 2954217 Regulation AKT2 TM4SF19 25344917 2206252 Regulation AKT2 TNF 11238593 1519022 Regulation AKT2 TNF 15841081 425880 Regulation AKT2 TNF 17208518 3203990 Regulation AKT2 TNF 18443205 705817 Regulation AKT2 TNF 21949832 2556715 Regulation AKT2 TNF 22973314 1068931 Regulation AKT2 TNF 23800251 1627195 Regulation AKT2 TNF 23800251 1627196 Regulation AKT2 TNF 23800251 1627197 Regulation AKT2 TNF 23800251 1627198 Regulation AKT2 TNF 25162582 3002933 Regulation AKT2 TNF 25352752 1917458 Regulation AKT2 TNF 25352752 1917482 Regulation AKT2 TNFSF10 20661217 2133114 Regulation AKT2 TNFSF10 25277183 2203062 Regulation AKT2 TP63 19517019 2419059 Regulation AKT3 ABCG2 24281174 501832 Regulation AKT3 ANGPT1 22454630 832640 Regulation AKT3 ANGPT1 25329960 3016933 Regulation AKT3 ANGPT1 25329960 3017046 Regulation AKT3 ARSA 19966835 8434 Regulation AKT3 BPI 22545124 2623473 Regulation AKT3 CCND1 21931533 2277086 Regulation AKT3 CCND1 22481935 1673576 Regulation AKT3 CCND1 23300578 2733866 Regulation AKT3 CCND1 23533654 2771117 Regulation AKT3 CCND1 24690900 2947241 Regulation AKT3 CCND1 24858012 2973334 Regulation AKT3 CD14 20011115 3045859 Regulation AKT3 CD22 25101192 3151875 Regulation AKT3 CEACAM6 25398131 3027604 Regulation AKT3 CHI3L1 19414556 1554757 Regulation AKT3 EFNB1 21795402 1793158 Regulation AKT3 EFNB1 21795402 1793223 Regulation AKT3 EPHB2 19255520 1704034 Regulation AKT3 EPHB2 21559368 2519006 Regulation AKT3 EPHB2 21699731 1862571 Regulation AKT3 EPHB2 21762482 387029 Regulation AKT3 EPHB2 22312244 1094828 Regulation AKT3 EPHB2 22649371 874902 Regulation AKT3 EPHB2 22967907 1506591 Regulation AKT3 EPHB2 23531532 1103319 Regulation AKT3 EPHB2 23554919 2773954 Regulation AKT3 EPHB2 23554919 2774008 Regulation AKT3 F2R 23236426 2726352 Regulation AKT3 F2R 23239877 1205875 Regulation AKT3 FAS 21713032 2276556 Regulation AKT3 FHL1 24952875 274074 Regulation AKT3 FOXO1 20375467 27026 Regulation AKT3 FOXO1 20398329 465416 Regulation AKT3 FOXO1 21479203 2511166 Regulation AKT3 FOXO1 24162775 1959298 Regulation AKT3 FOXO1 24740015 2954348 Regulation AKT3 FOXO1 25400915 1037022 Regulation AKT3 GAB3 23805312 2808437 Regulation AKT3 HBEGF 19470173 1503704 Regulation AKT3 IFI27 24858012 2973335 Regulation AKT3 INPP4B 21487159 2175792 Regulation AKT3 INPP4B 22895072 478786 Regulation AKT3 INPP4B 22895072 478801 Regulation AKT3 INPP4B 24500884 492414 Regulation AKT3 KANK4 18458160 1351937 Regulation AKT3 KANK4 18458160 1352025 Regulation AKT3 KANK4 18458160 1352065 Regulation AKT3 MAP2K6 16103225 1323234 Regulation AKT3 MAP2K6 17088902 428277 Regulation AKT3 MAP2K6 18598360 480542 Regulation AKT3 MAP2K6 18729301 3231426 Regulation AKT3 MAP2K6 19917087 1676434 Regulation AKT3 MAP2K6 19917087 1676435 Regulation AKT3 MAP2K6 21762482 387035 Regulation AKT3 MAP2K6 22348085 2596798 Regulation AKT3 MAP2K6 22649371 874908 Regulation AKT3 MAP2K6 22649371 874988 Regulation AKT3 MAP2K6 22909302 138140 Regulation AKT3 MAP2K6 23049945 2699911 Regulation AKT3 MAP2K6 23112573 1915215 Regulation AKT3 MAP2K6 23531532 1103327 Regulation AKT3 MAP2K6 24475138 2914915 Regulation AKT3 MAP2K6 24970815 2194108 Regulation AKT3 MAP2K6 24970815 2194162 Regulation AKT3 NGFR 22880054 2673831 Regulation AKT3 NGFR 22880054 2673899 Regulation AKT3 RCAN1 19124655 1553368 Regulation AKT3 RGS2 25309327 871493 Regulation AKT3 SELL 23183047 1570188 Regulation AKT3 SPHK1 19956567 2432080 Regulation AKT3 SPHK1 21625639 2525225 Regulation AKT3 SPHK1 22961081 724500 Regulation AKT3 SYNM 22337773 1800674 Regulation AKT3 TCN1 20489726 546942 Regulation AKT3 TCN1 20489726 547048 Regulation AKT3 THSD7A 22194972 2583579 Regulation AKT3 TLR7 24367261 3065458 Regulation AKT3 TLR7 24740015 2954236 Regulation AKT3 TLR7 24740015 2954237 Regulation AKT3 TM4SF19 25344917 2206258 Regulation AKT3 TNF 11238593 1519023 Regulation AKT3 TNF 15841081 425881 Regulation AKT3 TNF 17208518 3203992 Regulation AKT3 TNF 18443205 705820 Regulation AKT3 TNF 21949832 2556717 Regulation AKT3 TNF 22973314 1068935 Regulation AKT3 TNF 23800251 1627203 Regulation AKT3 TNF 23800251 1627204 Regulation AKT3 TNF 23800251 1627205 Regulation AKT3 TNF 23800251 1627206 Regulation AKT3 TNF 25162582 3002934 Regulation AKT3 TNF 25352752 1917460 Regulation AKT3 TNF 25352752 1917484 Regulation AKT3 TNFSF10 20661217 2133115 Regulation AKT3 TNFSF10 25277183 2203063 Regulation AKT3 TP63 19517019 2419060 Regulation ALB HES2 PMC3332944 660993 Regulation ALDH1A1 HRH1 25045085 492838 Regulation ALDH1A1 MUC16 24594504 2118553 Regulation ALDH1A2 EPHB2 19252500 1960635 Regulation ALDH1A2 TLR7 24788806 2959580 Regulation ALDH1A3 TNF 22768131 2659839 Regulation ALDH2 AKT1 20617031 1075686 Regulation ALDH2 AKT2 20617031 1075687 Regulation ALDH2 AKT3 20617031 1075688 Regulation ALDH2 FOXO3 20617031 1075685 Regulation ALDH2 NFE2L2 21249230 2494452 Regulation ALDH2 PRKAA1 20617031 1075689 Regulation ALDH2 PRKAA2 20617031 1075690 Regulation ALDH2 PRKAB1 20617031 1075691 Regulation ALDH2 PRKAB2 20617031 1075692 Regulation ALDH2 PRKAG1 20617031 1075693 Regulation ALDH2 PRKAG2 20617031 1075694 Regulation ALDH2 RARB 22389816 1152765 Regulation ALOX5 ABL1 19503090 1948735 Regulation ALOX5 AFF1 25402609 2160688 Regulation ALOX5 ALOX5 24475136 2914871 Regulation ALOX5 ALOX5AP 1469057 1302691 Regulation ALOX5 BCR 19503090 1948732 Regulation ALOX5 BLK 22797726 1951252 Regulation ALOX5 CD79A 19503090 1948733 Regulation ALOX5 CD79B 19503090 1948734 Regulation ALOX5 EGF 16872537 3107534 Regulation ALOX5 ELL 25402609 2160731 Regulation ALOX5 EPHB2 23015755 1807747 Regulation ALOX5 HDAC1 25402609 2160679 Regulation ALOX5 HDAC1 25402609 2160680 Regulation ALOX5 HDAC1 25402609 2160681 Regulation ALOX5 HDAC2 25402609 2160682 Regulation ALOX5 HDAC2 25402609 2160683 Regulation ALOX5 HDAC2 25402609 2160684 Regulation ALOX5 IL10 12417634 1525203 Regulation ALOX5 ITIH4 22236409 3119944 Regulation ALOX5 KMT2A 25402609 2160685 Regulation ALOX5 KMT2A 25402609 2160686 Regulation ALOX5 KMT2A 25402609 2160687 Regulation ALOX5 KMT2A 25402609 2160732 Regulation ALOX5 KMT2A 25402609 2160733 Regulation ALOX5 KMT2A 25402609 2160734 Regulation ALOX5 NELFCD 24832045 176594 Regulation ALOX5 NOX1 17625512 1902339 Regulation ALOX5 NOX3 17625512 1902340 Regulation ALOX5 NOX4 17625512 1902341 Regulation ALOX5 NOX5 17625512 1902338 Regulation ALOX5 PLG 21364954 2504554 Regulation ALOX5 PLG 21364954 2504555 Regulation ALOX5 PLG 21364954 2504562 Regulation ALOX5 RBBP4 25402609 2160689 Regulation ALOX5 RBBP4 25402609 2160690 Regulation ALOX5 RBBP4 25402609 2160691 Regulation ALOX5 RBBP7 25402609 2160692 Regulation ALOX5 RBBP7 25402609 2160693 Regulation ALOX5 RBBP7 25402609 2160694 Regulation ALOX5 SP1 20046412 3231733 Regulation ALOX5 TCEA1 25402609 2160730 Regulation ALOX5 TLR4 25116953 2996586 Regulation ALOX5 TLR4 25116953 2996589 Regulation ALOX5 TLR4 25116953 2996591 Regulation ALOX5 TLR4 25116953 2996595 Regulation ALOX5 UGCG 19497113 113469 Regulation ALOX5AP EPHB2 23015755 1807748 Regulation ALOX5AP IL1B 23409001 2753152 Regulation ALPI TNFSF10 25593641 206970 Regulation ALS2 CABP4 24651125 2936436 Regulation ALS3 CABP4 24651125 2936441 Regulation ALS5 CABP4 24651125 2936446 Regulation ALS7 CABP4 24651125 2936431 Regulation ANG PLAU 20805979 2471614 Regulation ANG PLAU 20805979 2471618 Regulation ANGPT1 ACE 24459521 746281 Regulation ANGPT1 ACE 24639651 953692 Regulation ANGPT1 ACE2 24459521 746280 Regulation ANGPT1 AKT1 19771215 1685964 Regulation ANGPT1 AKT2 19771215 1685965 Regulation ANGPT1 AKT3 19771215 1685966 Regulation ANGPT1 ANG 25337950 3018414 Regulation ANGPT1 ANGPT2 19922791 613201 Regulation ANGPT1 ANGPT2 20687922 855077 Regulation ANGPT1 ANGPT2 24106271 1208384 Regulation ANGPT1 ANGPT2 24270910 453560 Regulation ANGPT1 ANGPT2 25332783 2214743 Regulation ANGPT1 ARG1 23840386 2812680 Regulation ANGPT1 ARG1 24106271 1208389 Regulation ANGPT1 ARG2 23840386 2812681 Regulation ANGPT1 ARG2 24106271 1208390 Regulation ANGPT1 DBT 22927877 815042 Regulation ANGPT1 DBT 22927877 815051 Regulation ANGPT1 DUSP1 24308939 1158683 Regulation ANGPT1 DUSP1 24308939 1158726 Regulation ANGPT1 DUSP1 24308939 1158727 Regulation ANGPT1 DUSP10 24308939 1158684 Regulation ANGPT1 DUSP11 24308939 1158685 Regulation ANGPT1 DUSP12 24308939 1158686 Regulation ANGPT1 DUSP13 24308939 1158678 Regulation ANGPT1 DUSP14 24308939 1158674 Regulation ANGPT1 DUSP15 24308939 1158673 Regulation ANGPT1 DUSP16 24308939 1158675 Regulation ANGPT1 DUSP18 24308939 1158676 Regulation ANGPT1 DUSP19 24308939 1158677 Regulation ANGPT1 DUSP2 24308939 1158687 Regulation ANGPT1 DUSP21 24308939 1158679 Regulation ANGPT1 DUSP22 24308939 1158672 Regulation ANGPT1 DUSP23 24308939 1158680 Regulation ANGPT1 DUSP26 24308939 1158682 Regulation ANGPT1 DUSP27 24308939 1158681 Regulation ANGPT1 DUSP28 24308939 1158695 Regulation ANGPT1 DUSP3 24308939 1158688 Regulation ANGPT1 DUSP4 24308939 1158515 Regulation ANGPT1 DUSP4 24308939 1158689 Regulation ANGPT1 DUSP4 24308939 1158913 Regulation ANGPT1 DUSP5 24308939 1158516 Regulation ANGPT1 DUSP5 24308939 1158690 Regulation ANGPT1 DUSP5 24308939 1158938 Regulation ANGPT1 DUSP6 24308939 1158691 Regulation ANGPT1 DUSP7 24308939 1158692 Regulation ANGPT1 DUSP8 24308939 1158693 Regulation ANGPT1 DUSP9 24308939 1158694 Regulation ANGPT1 EFNB1 21795402 1793239 Regulation ANGPT1 EGR1 24308939 1158914 Regulation ANGPT1 FGF2 12070283 1523616 Regulation ANGPT1 FGF7 22974286 1626678 Regulation ANGPT1 IL6 19737862 1556175 Regulation ANGPT1 IL6 19737862 1556180 Regulation ANGPT1 IL6 19737862 1556182 Regulation ANGPT1 JUN 24308939 1158696 Regulation ANGPT1 MCS 24270910 453555 Regulation ANGPT1 MCS 24270910 453556 Regulation ANGPT1 MRXS5 12956885 3095080 Regulation ANGPT1 MSC 20554518 1188168 Regulation ANGPT1 MSC 20554518 1188172 Regulation ANGPT1 NA 22927877 815043 Regulation ANGPT1 NA 22927877 815052 Regulation ANGPT1 PI3 19771215 1685967 Regulation ANGPT1 PLAT 22432023 2611597 Regulation ANGPT1 PLAU 20805979 2471621 Regulation ANGPT1 POSTN 25369801 1887274 Regulation ANGPT1 POSTN 25369801 1887276 Regulation ANGPT1 PTPN6 22454630 832633 Regulation ANGPT1 PTPN6 22454630 832656 Regulation ANGPT1 PTPRS 23213447 168840 Regulation ANGPT1 REG1A 22454630 832634 Regulation ANGPT1 SHH 23894369 2824410 Regulation ANGPT1 SHH 23894369 2824411 Regulation ANGPT1 TIE1 19922791 613178 Regulation ANGPT1 TIE1 19922791 613179 Regulation ANGPT1 TIE1 19922791 613180 Regulation ANGPT1 TIE1 19922791 613219 Regulation ANGPT1 TIE1 19922791 613229 Regulation ANGPT1 TIE1 19922791 613239 Regulation ANGPT1 TIE1 22454630 832632 Regulation ANGPT1 TIE1 24308939 1158912 Regulation ANGPT1 TIE1 25336975 2123659 Regulation ANGPT1 VEGFA 12070283 1523615 Regulation ANGPT1 WT1 24810959 2190128 Regulation ANGPT1 ZNF350 21976967 1222775 Regulation ANGPT2 ANGPT1 24270910 453561 Regulation ANGPT2 CLU 25148511 3002040 Regulation ANGPT2 EPHB2 23691054 2794181 Regulation ANGPT2 EPHB2 24827991 2969861 Regulation ANGPT2 FOXO1 22144946 928868 Regulation ANGPT2 TNF 18922887 84781 Regulation ANGPT2 TNF 19416526 659189 Regulation ANGPT2 TNF 22500179 1143847 Regulation ANGPT2 TNF 22864384 1727517 Regulation ANGPT2 TNF 23251471 2728666 Regulation ANGPT2 TNF 23691105 2794536 Regulation ANGPTL4 EPHB2 23617883 1867923 Regulation ANK1 EFNB1 24023801 2843610 Regulation ANK1 EPHB2 24023801 2843614 Regulation ANK2 EFNB1 24023801 2843618 Regulation ANK2 EPHB2 24023801 2843622 Regulation ANK3 EFNB1 24023801 2843626 Regulation ANK3 EPHB2 24023801 2843630 Regulation ANKH TNF 22437419 1708997 Regulation ANKH TNF 22437419 1708998 Regulation ANKRD1 ANGPT2 25089522 2994531 Regulation ANKRD1 ANKRD12 22470472 2614246 Regulation ANKRD1 DDIT3 22639738 798303 Regulation ANKRD1 TCF12 22016770 2562511 Regulation ANKRD1 TCF15 22016770 2562512 Regulation ANKRD1 TCF19 22016770 2562513 Regulation ANKRD1 TCF20 22016770 2562514 Regulation ANKRD1 TCF21 22016770 2562515 Regulation ANKRD1 TCF23 22016770 2562519 Regulation ANKRD1 TCF24 22016770 2562521 Regulation ANKRD1 TCF25 22016770 2562520 Regulation ANKRD1 TCF3 22016770 2562516 Regulation ANKRD1 TCF4 22016770 2562517 Regulation ANKRD1 TCF7 22016770 2562518 Regulation ANKRD1 TP53 22016770 2562591 Regulation ANKRD1 TP53 22016770 2562615 Regulation ANKRD12 ANKRD1 22470472 2614247 Regulation ANKRD2 ANKRD1 22016770 2562537 Regulation ANKRD2 ANKRD1 22016770 2562608 Regulation ANO1 CA2 23994600 159569 Regulation ANO1 CA2 24081981 1610606 Regulation ANO1 CA2 24081981 1610610 Regulation ANO1 CA2 24420770 1611173 Regulation ANO1 CA2 24420770 1611182 Regulation ANO1 CA2 24420770 1611191 Regulation ANO1 CA2 24420770 1611214 Regulation ANO1 CA2 24901998 2977012 Regulation ANO1 CA2 24901998 2977026 Regulation ANO1 CA2 24901998 2977042 Regulation ANO1 CALM3 21642943 12814 Regulation ANO1 CALM3 24420770 1611159 Regulation ANO1 CALM3 24420770 1611183 Regulation ANO1 CALM3 24420770 1611203 Regulation ANO1 CALM3 24420770 1611204 Regulation ANO1 CALM3 24901998 2977013 Regulation ANO1 CALM3 24901998 2977019 Regulation ANO1 CALM3 24980701 759222 Regulation ANO1 CFTR 24885604 359403 Regulation ANO1 CFTR 24885604 359405 Regulation ANO1 ZNF282 21423668 2322580 Regulation ANXA1 TNF 14568984 1529255 Regulation ANXA1 TNF 18475719 1745580 Regulation ANXA2 NES 23226323 2724117 Regulation ANXA2 NES 23226323 2724122 Regulation ANXA2 NES 23226323 2724126 Regulation ANXA2 NES 23226323 2724128 Regulation ANXA2 NES 23434659 1101897 Regulation ANXA5 FAS 15144016 702432 Regulation ANXA6 ALOX5 23613965 2782922 Regulation ANXA6 EPHB2 22312244 1094830 Regulation ANXA6 EPHB2 22564882 2180164 Regulation ANXA6 EPHB2 24312679 2890641 Regulation ANXA6 TLR7 15851485 1535843 Regulation ANXA6 TLR7 23755218 2802048 Regulation AP2M1 MMP28 9683296 447424 Regulation AP2M1 MMP7 9683296 447439 Regulation APC ALDH2 23468836 2759751 Regulation APC ALDH2 23468836 2759754 Regulation APC AXIN2 10330403 1246283 Regulation APC F2R 17893198 1547111 Regulation APC F2R 24152910 220925 Regulation APC ITGAL 24376655 2901690 Regulation APC ITGAL 3919144 1583764 Regulation APC ITGB2 7525839 1589666 Regulation APC MYH16 20223032 1029763 Regulation APC MYH3 20223032 1029770 Regulation APC TLR7 23908972 864199 Regulation APC TLR7 25309534 914348 Regulation APCS EPHB2 24129161 1920093 Regulation APCS ITGB2 22474478 634216 Regulation APCS ITGB2 24376655 2901745 Regulation APCS TCN1 20237826 2243937 Regulation APLP2 PCSK9 23430252 1206579 Regulation APLP2 PCSK9 23430252 1206580 Regulation APOA1 CD14 23781332 627802 Regulation APOA1 EPHB2 20102334 651199 Regulation APOB G0S2 23951308 2834128 Regulation APOB PCSK9 21232153 1723405 Regulation APOB PCSK9 22355267 1059717 Regulation APOB PCSK9 22355267 1059719 Regulation APOB PCSK9 22355267 1059720 Regulation APOB PCSK9 23329883 1084343 Regulation APOB PCSK9 23936445 2830938 Regulation APOB PCSK9 24276320 2244638 Regulation APOB PCSK9 24278757 3150685 Regulation APOB PCSK9 25172365 785274 Regulation APOB TNF 7577459 444040 Regulation APOB TNFSF10 24466325 2914328 Regulation APOBEC1 RNASE1 18509452 2389854 Regulation APOBEC1 RNASE7 18509452 2389862 Regulation APOBEC2 RNASE1 18509452 2389868 Regulation APOBEC2 RNASE7 18509452 2389876 Regulation APOBEC3G EPHB2 19371434 3117757 Regulation APOBEC3G RNASE1 17291161 3039472 Regulation APOBEC3G RNASE7 17291161 3039480 Regulation APOBEC4 RNASE1 18509452 2389840 Regulation APOBEC4 RNASE7 18509452 2389848 Regulation APOE PCSK9 23883163 1726235 Regulation APOE TNF 18678613 706671 Regulation APOE TNF 18678613 706672 Regulation APOE TNF 23843680 1753851 Regulation APOE TNF 24244577 2880458 Regulation APOM FOXA1 25144649 3001137 Regulation APP ALOX5 22222029 1894619 Regulation APP EPHB2 22103431 651468 Regulation APP PCSK9 23430252 1206581 Regulation APP SORL1 22621900 1803307 Regulation APP SORL1 22621900 1803318 Regulation APP SORL1 22727043 406268 Regulation APP SORL1 22727043 406269 Regulation APP SORL1 22727043 406270 Regulation APP SORL1 23429712 650713 Regulation APP TNF 22047170 1660194 Regulation APP TNF 25426144 695964 Regulation AQP1 MYH16 23029347 2696747 Regulation AQP1 MYH3 23029347 2696754 Regulation AQP1 TNF 20383338 1910660 Regulation AQP1 TNF 24369440 1755930 Regulation AQP1 TNF 25371738 845397 Regulation AQP2 EPHB2 18431594 2242545 Regulation AQP4 LBP 22438957 2612190 Regulation AQP5 TNF 24369440 1755931 Regulation AR ADRB2 25629002 949780 Regulation AR FOXA1 22879989 2673402 Regulation ARC EPHB2 21559295 2518079 Regulation ARC EPHB2 24045785 3137160 Regulation ARC EPHB2 24045785 3137161 Regulation ARC MAP2K6 21242991 1900749 Regulation ARCN1 S100A7 21324122 396334 Regulation AREG MAP2K6 20034375 1676674 Regulation AREG MMP28 21489260 362975 Regulation AREG MMP7 21489260 362990 Regulation AREG SPHK1 21936950 1697753 Regulation ARF1 EPHB2 23349934 2744087 Regulation ARF1 FOXO1 20878915 775201 Regulation ARF1 TLR7 23162766 2161617 Regulation ARF3 EPHB2 23349934 2744088 Regulation ARF3 FOXO1 20878915 775205 Regulation ARF3 TLR7 23162766 2161627 Regulation ARF4 EPHB2 23349934 2744089 Regulation ARF4 FOXO1 20878915 775209 Regulation ARF4 TLR7 23162766 2161637 Regulation ARF5 EPHB2 23349934 2744090 Regulation ARF5 FOXO1 20878915 775213 Regulation ARF5 TLR7 23162766 2161647 Regulation ARF6 EPHB2 23349934 2744091 Regulation ARF6 FOXO1 20878915 775217 Regulation ARF6 TLR7 23162766 2161657 Regulation ARFRP1 FOXO1 17010188 232456 Regulation ARG1 EPHB2 21559295 2518080 Regulation ARG1 TLR7 21246055 2492995 Regulation ARG2 EPHB2 21559295 2518081 Regulation ARHGAP22 RCAN1 19603121 1832616 Regulation ARHGAP4 RAB31 11927603 1280619 Regulation ARHGEF1 TNF 21473788 1658075 Regulation ARHGEF2 EPHB2 22593214 1803227 Regulation ARHGEF2 EPHB2 23389627 1811835 Regulation ARHGEF2 EPHB2 23389627 1811902 Regulation ARHGEF2 MAP2K6 22593214 1803233 Regulation ARHGEF2 TNF 20089843 1773456 Regulation ARHGEF7 PECAM1 20723025 1692115 Regulation ARID1A EPHB2 24811485 2190645 Regulation ARID1A TNF 16177180 2017714 Regulation ARID1B EPHB2 21572418 1925874 Regulation ARID1B EPHB2 21860657 813153 Regulation ARL4D LGR4 24686251 2947174 Regulation ARL4D LGR5 24686251 2947176 Regulation ARL4D LGR6 24686251 2947175 Regulation ARNTL PGC 23434656 1101853 Regulation ARNTL2 SERPINA5 23148642 339570 Regulation ARRB1 EPHB2 22988512 155673 Regulation ARSA NAA10 22837307 724011 Regulation ARSA NAA10 22837307 724012 Regulation ARSA NAA11 22837307 724027 Regulation ARSA NAA11 22837307 724028 Regulation ARSA NAA15 22837307 724031 Regulation ARSA NAA15 22837307 724032 Regulation ARSA NAA16 22837307 724025 Regulation ARSA NAA16 22837307 724026 Regulation ARSA NAA20 22837307 724009 Regulation ARSA NAA20 22837307 724010 Regulation ARSA NAA25 22837307 724019 Regulation ARSA NAA25 22837307 724020 Regulation ARSA NAA30 22837307 724013 Regulation ARSA NAA30 22837307 724014 Regulation ARSA NAA35 22837307 724017 Regulation ARSA NAA35 22837307 724018 Regulation ARSA NAA38 22837307 724015 Regulation ARSA NAA38 22837307 724016 Regulation ARSA NAA40 22837307 724021 Regulation ARSA NAA40 22837307 724022 Regulation ARSA NAA50 22837307 724029 Regulation ARSA NAA50 22837307 724030 Regulation ARSA NAA60 22837307 724023 Regulation ARSA NAA60 22837307 724024 Regulation ARSA NOS3 25045211 1760206 Regulation ARSA PTPN6 23390550 2750899 Regulation ARSD GRIK2 24533017 685193 Regulation ART1 FAS 25520826 1630312 Regulation ART3 FAS 25520826 1630313 Regulation ART4 FAS 25520826 1630314 Regulation ART5 FAS 25520826 1630311 Regulation ASAH1 SPHK1 22961081 724497 Regulation ASIP OSR1 25221402 89049 Regulation ATF1 EPHB2 18382618 831310 Regulation ATF1 EPHB2 24132149 1113499 Regulation ATF2 EPHB2 18382618 831311 Regulation ATF2 EPHB2 19765307 254169 Regulation ATF2 EPHB2 20581861 2132808 Regulation ATF2 TNF 20507572 353448 Regulation ATF3 EPHB2 18382618 831312 Regulation ATF3 EPHB2 25136830 2999041 Regulation ATF3 EPHB2 25136830 2999104 Regulation ATF3 FOXO1 23462798 733747 Regulation ATF3 MAP2K6 25136830 2999043 Regulation ATF4 EGLN3 24809345 2358953 Regulation ATF4 EPHB2 18382618 831313 Regulation ATF5 CREB3L2 20495567 1961049 Regulation ATF5 CREB3L2 20495567 1961062 Regulation ATF5 EPHB2 18382618 831315 Regulation ATF6 EPHB2 18382618 831316 Regulation ATF6 PGC 23716639 2088893 Regulation ATF6 PGC 23716639 2088897 Regulation ATF6 PGC 23716639 2088898 Regulation ATF6 RCAN1 20145727 1065911 Regulation ATF7 EPHB2 18382618 831317 Regulation ATG10 FOXO1 22281705 547780 Regulation ATG10 FOXO1 24474199 3081385 Regulation ATG10 FOXO1 25375380 579007 Regulation ATG10 IRS4 23300468 2341034 Regulation ATG10 IRS4 23300468 2341035 Regulation ATG12 FOXO1 22281705 547783 Regulation ATG12 FOXO1 24474199 3081388 Regulation ATG12 FOXO1 25375380 579010 Regulation ATG12 IRS4 23300468 2341046 Regulation ATG12 IRS4 23300468 2341047 Regulation ATG13 FOXO1 22281705 547782 Regulation ATG13 FOXO1 24474199 3081387 Regulation ATG13 FOXO1 25375380 579009 Regulation ATG13 IRS4 23300468 2341042 Regulation ATG13 IRS4 23300468 2341043 Regulation ATG14 FOXO1 22281705 547779 Regulation ATG14 FOXO1 24474199 3081384 Regulation ATG14 FOXO1 25375380 579006 Regulation ATG14 IRS4 23300468 2341030 Regulation ATG14 IRS4 23300468 2341031 Regulation ATG3 CLU 25503391 1947696 Regulation ATG3 CLU 25503391 1947697 Regulation ATG3 FOXO1 22281705 547781 Regulation ATG3 FOXO1 24474199 3081386 Regulation ATG3 FOXO1 25375380 579008 Regulation ATG3 IRS4 23300468 2341038 Regulation ATG3 IRS4 23300468 2341039 Regulation ATG5 FOXO1 22281705 547784 Regulation ATG5 FOXO1 24474199 3081389 Regulation ATG5 FOXO1 25375380 579011 Regulation ATG5 IRS4 23300468 2341050 Regulation ATG5 IRS4 23300468 2341051 Regulation ATG7 FOXO1 22281705 547778 Regulation ATG7 FOXO1 24474199 3081383 Regulation ATG7 FOXO1 25375380 579005 Regulation ATG7 IRS4 23300468 2341026 Regulation ATG7 IRS4 23300468 2341027 Regulation ATM AXIN2 22645520 874326 Regulation ATOH8 TF 24236640 450685 Regulation ATOH8 TF 24236640 450704 Regulation ATP5O CLU 23986700 858675 Regulation ATP5O EPHB2 24351799 3223672 Regulation ATP5O OSR1 21343295 1190838 Regulation ATP5O TMOD1 2380244 1405760 Regulation ATP5O TMOD1 24509847 1209001 Regulation ATP5O TMOD1 25520664 967250 Regulation ATP5O TNF 21694944 1140168 Regulation ATP5O UCA1 24993775 2171790 Regulation ATP6V0A4 FOXI1 19214237 2405767 Regulation ATP7A EPHB2 19351384 357980 Regulation ATR TNF 22768051 2659588 Regulation ATRAID IFI27 23509459 1073483 Regulation ATRX F2R 18842153 324272 Regulation ATXN1 TNF 11581316 1521086 Regulation AURKA NEDD9 25594051 2173928 Regulation AURKB WFDC2 23502467 1103019 Regulation AVP OXTR 22615702 972478 Regulation AXIN2 ACTR1A 23155463 2717837 Regulation AXIN2 AKAP9 23155463 2717872 Regulation AXIN2 AKT1 22473005 610540 Regulation AXIN2 AKT1 22473005 610581 Regulation AXIN2 AKT2 22473005 610541 Regulation AXIN2 AKT2 22473005 610582 Regulation AXIN2 AKT3 22473005 610542 Regulation AXIN2 AKT3 22473005 610583 Regulation AXIN2 ALMS1 23155463 2717873 Regulation AXIN2 APC 14551908 2255049 Regulation AXIN2 CAPRIN2 18762581 1357028 Regulation AXIN2 CDK1 23155463 2717840 Regulation AXIN2 CDK5RAP2 23155463 2717845 Regulation AXIN2 CENPJ 23155463 2717841 Regulation AXIN2 CEP135 23155463 2717863 Regulation AXIN2 CEP152 23155463 2717867 Regulation AXIN2 CEP164 23155463 2717865 Regulation AXIN2 CEP192 23155463 2717850 Regulation AXIN2 CEP250 23155463 2717843 Regulation AXIN2 CEP290 23155463 2717861 Regulation AXIN2 CEP57 23155463 2717871 Regulation AXIN2 CEP63 23155463 2717856 Regulation AXIN2 CEP70 23155463 2717870 Regulation AXIN2 CEP72 23155463 2717852 Regulation AXIN2 CEP76 23155463 2717854 Regulation AXIN2 CEP78 23155463 2717855 Regulation AXIN2 CETN2 23155463 2717844 Regulation AXIN2 CKAP5 23155463 2717860 Regulation AXIN2 CLASP1 23155463 2717839 Regulation AXIN2 CSNK1D 23155463 2717848 Regulation AXIN2 CSNK1E 23155463 2717849 Regulation AXIN2 DCTN1 23155463 2717857 Regulation AXIN2 DCTN2 23155463 2717858 Regulation AXIN2 DCTN3 23155463 2717859 Regulation AXIN2 DVL1 14734535 1305063 Regulation AXIN2 DVL2 14734535 1305064 Regulation AXIN2 DVL2 25024088 1943454 Regulation AXIN2 DVL3 14734535 1305065 Regulation AXIN2 DYNC1H1 23155463 2717868 Regulation AXIN2 DYNC1I2 23155463 2717869 Regulation AXIN2 DYNLL1 23155463 2717835 Regulation AXIN2 FBXL20 24932313 2168550 Regulation AXIN2 FGFR1OP 23155463 2717838 Regulation AXIN2 GSK3B 25051360 2196705 Regulation AXIN2 HAUS2 23155463 2717851 Regulation AXIN2 HDAC1 23110995 3091535 Regulation AXIN2 HDAC1 23110995 3091551 Regulation AXIN2 HDAC1 23110995 3091557 Regulation AXIN2 HDAC1 24474204 3081490 Regulation AXIN2 HDAC2 23110995 3091536 Regulation AXIN2 HDAC2 23110995 3091552 Regulation AXIN2 HDAC2 23110995 3091558 Regulation AXIN2 HNF1A 22859735 2080246 Regulation AXIN2 HSP90AA1 23155463 2717874 Regulation AXIN2 MAPRE1 23155463 2717875 Regulation AXIN2 MBP 11524435 1274068 Regulation AXIN2 NDE1 23155463 2717842 Regulation AXIN2 NEDD1 23155463 2717876 Regulation AXIN2 NEK2 23155463 2717877 Regulation AXIN2 NINL 23155463 2717864 Regulation AXIN2 NKD1 19888210 1903143 Regulation AXIN2 NKD2 19888210 1903144 Regulation AXIN2 NOTCH1 11266469 1269216 Regulation AXIN2 ODF2 23155463 2717878 Regulation AXIN2 OFD1 23155463 2717853 Regulation AXIN2 PAFAH1B1 23155463 2717879 Regulation AXIN2 PCM1 23155463 2717880 Regulation AXIN2 PCNT 23155463 2717836 Regulation AXIN2 PKN1 24114839 1208483 Regulation AXIN2 PLCH1 23155463 2717866 Regulation AXIN2 PLK1 23155463 2717479 Regulation AXIN2 PLK1 23155463 2717881 Regulation AXIN2 PLK4 23155463 2717830 Regulation AXIN2 PPP2R1A 23155463 2717882 Regulation AXIN2 PRKACA 23155463 2717883 Regulation AXIN2 PRKAR2B 23155463 2717884 Regulation AXIN2 RBBP4 23110995 3091553 Regulation AXIN2 RBBP7 23110995 3091554 Regulation AXIN2 RNF146 24454854 2910147 Regulation AXIN2 RNF146 24454854 2910177 Regulation AXIN2 RNF146 24454854 2910178 Regulation AXIN2 RNF146 24454854 2910204 Regulation AXIN2 SDCCAG8 23155463 2717828 Regulation AXIN2 SFI1 23155463 2717862 Regulation AXIN2 SNAI1 24178749 783308 Regulation AXIN2 SSNA1 23155463 2717829 Regulation AXIN2 STK11 25295095 2170009 Regulation AXIN2 TCF12 22427816 2610371 Regulation AXIN2 TCF15 22427816 2610372 Regulation AXIN2 TCF19 22427816 2610373 Regulation AXIN2 TCF20 22427816 2610374 Regulation AXIN2 TCF21 22427816 2610375 Regulation AXIN2 TCF23 22427816 2610379 Regulation AXIN2 TCF24 22427816 2610381 Regulation AXIN2 TCF25 22427816 2610380 Regulation AXIN2 TCF3 11524435 1274059 Regulation AXIN2 TCF3 11524435 1274073 Regulation AXIN2 TCF3 22427816 2610376 Regulation AXIN2 TCF4 22427816 2610377 Regulation AXIN2 TCF7 22427816 2610378 Regulation AXIN2 TCF7L1 22859735 2080247 Regulation AXIN2 TCF7L2 22859735 2080248 Regulation AXIN2 TCF7L2 23966864 2348821 Regulation AXIN2 TUBA1A 23155463 2717846 Regulation AXIN2 TUBA4A 23155463 2717831 Regulation AXIN2 TUBB 23155463 2717847 Regulation AXIN2 TUBG1 23155463 2717832 Regulation AXIN2 USP34 25203062 3006219 Regulation AXIN2 WNT1 19225568 2405954 Regulation AXIN2 WNT1 21685894 1926493 Regulation AXIN2 WNT1 22022527 2563637 Regulation AXIN2 WNT1 22457761 2613648 Regulation AXIN2 WNT1 22859735 2080215 Regulation AXIN2 WNT1 23144924 2714918 Regulation AXIN2 WNT1 24260306 2883799 Regulation AXIN2 WNT11 19225568 2405955 Regulation AXIN2 WNT11 21685894 1926494 Regulation AXIN2 WNT11 22022527 2563638 Regulation AXIN2 WNT11 22457761 2613649 Regulation AXIN2 WNT11 22859735 2080216 Regulation AXIN2 WNT11 23144924 2714919 Regulation AXIN2 WNT11 24260306 2883800 Regulation AXIN2 WNT16 19225568 2405960 Regulation AXIN2 WNT16 21685894 1926499 Regulation AXIN2 WNT16 22022527 2563643 Regulation AXIN2 WNT16 22457761 2613654 Regulation AXIN2 WNT16 22859735 2080221 Regulation AXIN2 WNT16 23144924 2714924 Regulation AXIN2 WNT16 24260306 2883805 Regulation AXIN2 WNT2 19225568 2405956 Regulation AXIN2 WNT2 21685894 1926495 Regulation AXIN2 WNT2 22022527 2563639 Regulation AXIN2 WNT2 22457761 2613650 Regulation AXIN2 WNT2 22859735 2080217 Regulation AXIN2 WNT2 23144924 2714920 Regulation AXIN2 WNT2 24260306 2883801 Regulation AXIN2 WNT3 19225568 2405957 Regulation AXIN2 WNT3 21685894 1926496 Regulation AXIN2 WNT3 22022527 2563640 Regulation AXIN2 WNT3 22457761 2613651 Regulation AXIN2 WNT3 22859735 2080218 Regulation AXIN2 WNT3 23144924 2714921 Regulation AXIN2 WNT3 24260306 2883802 Regulation AXIN2 WNT3A 17961224 1645838 Regulation AXIN2 WNT3A 22479388 2615049 Regulation AXIN2 WNT3A 22928951 307651 Regulation AXIN2 WNT3A 24114839 1208438 Regulation AXIN2 WNT3A 24114839 1208488 Regulation AXIN2 WNT4 19225568 2405958 Regulation AXIN2 WNT4 21685894 1926497 Regulation AXIN2 WNT4 22022527 2563641 Regulation AXIN2 WNT4 22457761 2613652 Regulation AXIN2 WNT4 22859735 2080219 Regulation AXIN2 WNT4 23144924 2714922 Regulation AXIN2 WNT4 24260306 2883803 Regulation AXIN2 WNT5A 24670389 3140791 Regulation AXIN2 WNT6 19225568 2405959 Regulation AXIN2 WNT6 21685894 1926498 Regulation AXIN2 WNT6 22022527 2563642 Regulation AXIN2 WNT6 22457761 2613653 Regulation AXIN2 WNT6 22859735 2080220 Regulation AXIN2 WNT6 23144924 2714923 Regulation AXIN2 WNT6 24260306 2883804 Regulation AXIN2 YWHAE 23155463 2717833 Regulation AXIN2 YWHAG 23155463 2717834 Regulation AXL MAP2K6 21496277 259549 Regulation B2M TNF 24236107 2878568 Regulation BAAT EPHB2 19066310 707403 Regulation BAAT PGC 22087241 2570698 Regulation BAAT TNF 22297440 806717 Regulation BACE1 TNF 22047170 1660195 Regulation BACE2 HKDC1 23903356 728342 Regulation BAD MAP2K6 22235275 2585745 Regulation BAIAP2 KANK4 18458160 1352114 Regulation BAMBI CTGF 21673687 436931 Regulation BAMBI CTGF 21673687 436933 Regulation BAMBI TLR7 20706677 979207 Regulation BARX1 MSX1 23316168 960791 Regulation BAX CLU 21042904 3204943 Regulation BAX EPHB2 21998736 2562284 Regulation BAX FOLR1 23319948 1674351 Regulation BAX KRT38 12499352 1290322 Regulation BAX KRT38 12499352 1290323 Regulation BAX KRT38 12499352 1290325 Regulation BAX LBP 24595452 2931326 Regulation BAX TNF 10359585 1511875 Regulation BAX TNF 18246321 1644005 Regulation BAX TNFSF10 17718901 1645625 Regulation BAX TNFSF10 22272225 2588429 Regulation BAX TSPAN1 22739984 556248 Regulation BBC3 TNF 23339680 3226543 Regulation BCAN MMP28 23071766 2704114 Regulation BCAN MMP7 23071766 2704129 Regulation BCAP29 TLR7 24740015 2954161 Regulation BCAP31 TLR7 24740015 2954137 Regulation BCAR1 FAS 22291036 1394920 Regulation BCL10 CAPN8 23823868 2283405 Regulation BCL10 CD22 22128838 1616581 Regulation BCL10 EPHB2 19161638 252258 Regulation BCL10 EPHB2 19161638 252264 Regulation BCL10 EPHB2 19305426 2124967 Regulation BCL10 TNF 10359585 1511876 Regulation BCL10 TNFSF10 18992144 251793 Regulation BCL10 TSPAN1 22739984 556270 Regulation BCL2 CAPN8 23274414 16707 Regulation BCL2 CAPN8 23823868 2283419 Regulation BCL2 CD22 22128838 1616582 Regulation BCL2 EPHB2 19161638 252259 Regulation BCL2 EPHB2 19161638 252265 Regulation BCL2 EPHB2 20462959 1776101 Regulation BCL2 EPHB2 20462959 1776102 Regulation BCL2 EPHB2 20462959 1776129 Regulation BCL2 EPHB2 20462959 1776130 Regulation BCL2 EPHB2 22770472 532795 Regulation BCL2 EPHB2 23118896 2712035 Regulation BCL2 EPHB2 23363601 1811552 Regulation BCL2 EPHB2 23363601 1811564 Regulation BCL2 FAS 17031406 428235 Regulation BCL2 FAS 21412278 551383 Regulation BCL2 JAG1 21738743 2533624 Regulation BCL2 LBP 24595452 2931327 Regulation BCL2 PECAM1 9252201 446535 Regulation BCL2 SPHK1 21625639 2525204 Regulation BCL2 STK39 11875716 420709 Regulation BCL2 TNF 10359585 1511877 Regulation BCL2 TNF 10359585 1511894 Regulation BCL2 TNF 17570844 233033 Regulation BCL2 TNF 23193206 729962 Regulation BCL2 TNF 23339680 3226544 Regulation BCL2 TNFSF10 18992144 251795 Regulation BCL2 TNFSF10 24113173 567643 Regulation BCL2 TNFSF10 25593641 206972 Regulation BCL2 TSPAN1 22739984 556292 Regulation BCL2A1 CAPN8 22745672 2655776 Regulation BCL2L1 FOXO1 24977668 2194647 Regulation BCL2L11 FOXO1 18549468 372009 Regulation BCL3 CAPN8 23823868 2283433 Regulation BCL3 CD22 22128838 1616583 Regulation BCL3 EPHB2 19161638 252260 Regulation BCL3 EPHB2 19161638 252266 Regulation BCL3 TNF 10359585 1511878 Regulation BCL3 TNFSF10 18992144 251797 Regulation BCL3 TSPAN1 22739984 556314 Regulation BCL5 CAPN8 23823868 2283363 Regulation BCL5 CD22 22128838 1616578 Regulation BCL5 EPHB2 19161638 252255 Regulation BCL5 EPHB2 19161638 252261 Regulation BCL5 TNF 10359585 1511872 Regulation BCL5 TNFSF10 18992144 251782 Regulation BCL5 TSPAN1 22739984 556182 Regulation BCL6 CAPN8 23823868 2283377 Regulation BCL6 CD22 22128838 1616579 Regulation BCL6 EPHB2 19161638 252256 Regulation BCL6 EPHB2 19161638 252262 Regulation BCL6 TNF 10359585 1511873 Regulation BCL6 TNFSF10 18992144 251784 Regulation BCL6 TSPAN1 22739984 556204 Regulation BCL9 CAPN8 23823868 2283391 Regulation BCL9 CD22 22128838 1616580 Regulation BCL9 EPHB2 19161638 252257 Regulation BCL9 EPHB2 19161638 252263 Regulation BCL9 TNF 10359585 1511874 Regulation BCL9 TNFSF10 18992144 251786 Regulation BCL9 TSPAN1 22739984 556226 Regulation BCR CD22 10209047 1511614 Regulation BCR CD22 19447770 3126147 Regulation BCR CD22 20098688 2437861 Regulation BCR CD22 20098688 2437868 Regulation BCR CD22 20098688 2437879 Regulation BCR CD22 21826145 1144684 Regulation BCR CD22 22545114 2623413 Regulation BCR CD22 22566885 899314 Regulation BCR CD22 22566885 899475 Regulation BCR CD22 PMC3991031 2245472 Regulation BCR FOXO1 18978794 1951901 Regulation BCR PECAM1 23233201 1141353 Regulation BCR PECAM1 23233201 1141370 Regulation BCRP1 ABCG2 24523596 2249876 Regulation BCRP1 MX2 22098950 624346 Regulation BCRP1 TNF 23840097 1753449 Regulation BCRP2 ABCG2 24523596 2249872 Regulation BCRP2 MX2 22098950 624338 Regulation BCRP2 TNF 23840097 1753441 Regulation BCRP3 ABCG2 24523596 2249873 Regulation BCRP3 MX2 22098950 624340 Regulation BCRP3 TNF 23840097 1753443 Regulation BCRP4 ABCG2 24523596 2249874 Regulation BCRP4 MX2 22098950 624342 Regulation BCRP4 TNF 23840097 1753445 Regulation BCRP5 ABCG2 24523596 2249875 Regulation BCRP5 MX2 22098950 624344 Regulation BCRP5 TNF 23840097 1753447 Regulation BCRP6 ABCG2 24523596 2249877 Regulation BCRP6 MX2 22098950 624348 Regulation BCRP6 TNF 23840097 1753451 Regulation BCRP7 ABCG2 24523596 2249878 Regulation BCRP7 MX2 22098950 624350 Regulation BCRP7 TNF 23840097 1753453 Regulation BCRP8 ABCG2 24523596 2249879 Regulation BCRP8 MX2 22098950 624352 Regulation BCRP8 TNF 23840097 1753455 Regulation BCRP9 ABCG2 24523596 2249880 Regulation BCRP9 MX2 22098950 624354 Regulation BCRP9 TNF 23840097 1753457 Regulation BDH1 TLR7 24863067 1576529 Regulation BDH1 TLR7 24863067 1576550 Regulation BDNF LBP 23894366 2824403 Regulation BDNF MAP2K6 20479872 2450069 Regulation BDNF PLAT 18813339 2396831 Regulation BDNF PLAT 18813339 2396835 Regulation BDNF PLAT 24647528 2936197 Regulation BDNF PLAT 24647528 2936199 Regulation BDNF TNF 24603712 2931984 Regulation BECN1 DAPK1 22095288 547709 Regulation BECN1 DAPK1 23095639 542378 Regulation BECN1 EPHB2 22276178 2590348 Regulation BECN1 EPHB2 25029544 1128406 Regulation BECN1 MAP2K6 22276178 2590355 Regulation BGLAP EPHB2 22942680 1096784 Regulation BGLAP FOXO1 25187705 1138332 Regulation BGLAP ID1 8045940 1444363 Regulation BGLAP TLR7 25610471 3174547 Regulation BGLAP TNF 18163903 1848454 Regulation BIRC2 EPHB2 23831571 2152764 Regulation BIRC2 TNF 18606850 1353536 Regulation BIRC2 TNF 23785514 2806653 Regulation BIRC2 TNFSF10 20062539 2436813 Regulation BIRC3 TNF 23785514 2806654 Regulation BLNK FOXO1 25400915 1037007 Regulation BMF EPHB2 22258404 554027 Regulation BMF MAP2K6 22258404 554024 Regulation BMF MAP2K6 22258404 554033 Regulation BMI1 ID1 24572994 1142529 Regulation BMP1 EFNB1 24662724 1941124 Regulation BMP1 ID1 22540193 244984 Regulation BMP1 JAG1 23560082 2776862 Regulation BMP1 MSX1 22140629 3086124 Regulation BMP1 NPNT 21937601 703072 Regulation BMP1 TNF 24743742 573950 Regulation BMP1 TP63 23986743 879164 Regulation BMP10 ID1 22540193 245000 Regulation BMP10 JAG1 23560082 2776892 Regulation BMP10 MSX1 22140629 3086132 Regulation BMP10 NPNT 21937601 703080 Regulation BMP10 TNF 24743742 573966 Regulation BMP10 TP63 23986743 879172 Regulation BMP15 ID1 22540193 244986 Regulation BMP15 JAG1 23560082 2776864 Regulation BMP15 MSX1 22140629 3086125 Regulation BMP15 NPNT 21937601 703073 Regulation BMP15 TNF 24743742 573952 Regulation BMP15 TP63 23986743 879165 Regulation BMP2 ANGPT1 25329960 3017038 Regulation BMP2 EPHB2 20668165 1779482 Regulation BMP2 ID1 22540193 244988 Regulation BMP2 JAG1 23560082 2776866 Regulation BMP2 JAG1 23560082 2776905 Regulation BMP2 MSX1 22140629 3086126 Regulation BMP2 MSX1 24160254 345728 Regulation BMP2 NPNT 21937601 703074 Regulation BMP2 TNF 24743742 573954 Regulation BMP2 TNF 25228904 914153 Regulation BMP2 TNF 25228904 914154 Regulation BMP2 TP63 23986743 879166 Regulation BMP3 ID1 22540193 244990 Regulation BMP3 JAG1 23560082 2776868 Regulation BMP3 MSX1 22140629 3086127 Regulation BMP3 NPNT 21937601 703075 Regulation BMP3 TNF 24743742 573956 Regulation BMP3 TP63 23986743 879167 Regulation BMP4 EPHB2 20130821 1065826 Regulation BMP4 ID1 22540193 244992 Regulation BMP4 JAG1 23560082 2776870 Regulation BMP4 MSX1 22140629 3086128 Regulation BMP4 MSX1 23316168 960786 Regulation BMP4 MSX1 23316168 960795 Regulation BMP4 MSX1 24160254 345732 Regulation BMP4 NPNT 21937601 703076 Regulation BMP4 NPNT 21937601 703083 Regulation BMP4 TNF 24743742 573958 Regulation BMP4 TP63 23316168 960731 Regulation BMP4 TP63 23316168 960732 Regulation BMP4 TP63 23986743 879168 Regulation BMP5 ID1 22540193 244994 Regulation BMP5 JAG1 23560082 2776872 Regulation BMP5 MSX1 22140629 3086129 Regulation BMP5 NPNT 21937601 703077 Regulation BMP5 TNF 24743742 573960 Regulation BMP5 TP63 23986743 879169 Regulation BMP6 ID1 22540193 244996 Regulation BMP6 JAG1 23560082 2776874 Regulation BMP6 MSX1 22140629 3086130 Regulation BMP6 NPNT 21937601 703078 Regulation BMP6 TNF 24743742 573962 Regulation BMP6 TP63 23986743 879170 Regulation BMP7 CTGF 21673687 436929 Regulation BMP7 ID1 22540193 244998 Regulation BMP7 JAG1 23560082 2776876 Regulation BMP7 MSX1 22140629 3086131 Regulation BMP7 MSX1 23316168 960733 Regulation BMP7 NPNT 21937601 703079 Regulation BMP7 TNF 24743742 573964 Regulation BMP7 TP63 23986743 879171 Regulation BPI TLR8 23626859 2785152 Regulation BPNT1 CD14 22570785 1688463 Regulation BPNT1 EPHB2 22817771 471878 Regulation BPTF MSX1 23029006 2694112 Regulation BRAF EPHB2 24578720 3177451 Regulation BRAF EPHB2 25344914 2206041 Regulation BRAF MAP2K6 23857250 2156958 Regulation BRAP TLR7 22484733 1957133 Regulation BRCA2 TP63 24823795 2100819 Regulation BSG PLAU 22443116 264370 Regulation BTG2 NGFR 23593219 2780362 Regulation BUB1 STK39 24025726 364019 Regulation BUB1B STK39 24025726 364036 Regulation BUB3 STK39 24025726 364052 Regulation BUD13 FOXO1 21689484 404988 Regulation BUD31 FOXO1 21689484 404990 Regulation C1orf228 EPHB2 22537317 355888 Regulation C1orf228 TLR7 17485511 1545666 Regulation C1orf228 TLR7 19609356 3044617 Regulation C22orf29 MAP2K6 24263101 569210 Regulation C3 FAS 21573156 2522699 Regulation C4BPA F2R 21489985 1191351 Regulation C5 ITGB2 2565948 1577430 Regulation C5AR1 TLR7 24814708 145470 Regulation C5AR2 SPHK1 22355325 2597209 Regulation C5AR2 TLR7 21630250 808296 Regulation C5AR2 TLR7 21630250 808320 Regulation C5AR2 TLR7 21630250 808342 Regulation C5AR2 TNF 24523571 1757465 Regulation CA1 CAPN8 24394804 1940211 Regulation CA1 EPHB2 23785474 2806382 Regulation CA12 ELF1 23349866 2743598 Regulation CA12 ELF2 23349866 2743599 Regulation CA12 ELF3 23349866 2743600 Regulation CA12 ELF4 23349866 2743601 Regulation CA12 ELF5 23349866 2743602 Regulation CA12 LGALS1 24748734 3179780 Regulation CA12 MT-CO2 19333419 1088115 Regulation CA12 MT-CO2 23314813 1500942 Regulation CA2 ANGPT1 24586553 2925431 Regulation CA2 CAPN8 21516125 2139244 Regulation CA2 CAPN8 21516125 2139245 Regulation CA2 CAPN8 24971566 2984728 Regulation CA2 CD22 17420266 1545164 Regulation CA2 CLU 22384125 2605996 Regulation CA2 DAPK1 PMC4033950 2245763 Regulation CA2 EDN2 24470488 1611240 Regulation CA2 EDN2 24470488 1611254 Regulation CA2 EPHB2 21037577 1954561 Regulation CA2 F2R 23405206 2752030 Regulation CA2 FAS 21713032 2276561 Regulation CA2 FAS 21713032 2276631 Regulation CA2 FAS 21713032 2276642 Regulation CA2 FAS 21713032 2276643 Regulation CA2 FAS 21713032 2276644 Regulation CA2 GLP1R 23094100 2706014 Regulation CA2 GPR115 17362227 1691878 Regulation CA2 GPR132 17362227 1691867 Regulation CA2 GPR87 17362227 1691947 Regulation CA2 LPCAT1 22676268 229989 Regulation CA2 MAP2K6 23439928 1714835 Regulation CA2 MAP2K6 24753814 206234 Regulation CA2 MYH16 25353002 1888772 Regulation CA2 MYH3 25353002 1888779 Regulation CA2 PTGER2 23638853 451471 Regulation CA2 RIC3 15824136 1319921 Regulation CA2 RIC3 15824136 1319922 Regulation CA2 RIC3 15824136 1319932 Regulation CA2 S100B 20827311 512996 Regulation CA2 S100B 22539925 951724 Regulation CA2 SPHK1 22719791 814721 Regulation CA2 SYT8 25206473 2004737 Regulation CA2 TMOD1 22500102 1223948 Regulation CA2 TNF 1658188 1539815 Regulation CA2 TNF 1658188 1539826 Regulation CA2 TNF 20227109 523194 Regulation CA2 TNF 22666474 2648192 Regulation CA2 TNF 22832601 453177 Regulation CA2 TNF 24303157 2251407 Regulation CA2 TNF 24303157 2251412 Regulation CA2 TNF 24466329 2914366 Regulation CA2 TNF 25076912 965646 Regulation CA7 TNF 23193206 729946 Regulation CA8 ANKRD1 25089522 2994535 Regulation CABP4 ARSD 24204377 885195 Regulation CABP4 SOS1 24920279 395066 Regulation CABP4 SOS2 24920279 395067 Regulation CABP4 SYT4 16618809 1329026 Regulation CACYBP CABP4 24646911 1125022 Regulation CADM1 FCGBP 22152070 262853 Regulation CADM1 TNF 23987139 412475 Regulation CADM2 FCGBP 22152070 262819 Regulation CADM2 TNF 23987139 412471 Regulation CADM3 FCGBP 22152070 262812 Regulation CADM3 TNF 23987139 412470 Regulation CADM4 FCGBP 22152070 262826 Regulation CADM4 TNF 23987139 412472 Regulation CALB1 EPHB2 24204683 2873237 Regulation CALCA GLP1R 22127824 731852 Regulation CALCA GLP1R 22693487 833128 Regulation CALCA GLP1R 22693487 833132 Regulation CALD1 CABP4 8408215 1448262 Regulation CALD1 MAP2K6 10330402 1246077 Regulation CALD1 MAP2K6 10330402 1246147 Regulation CALM3 EPHB2 25000310 216083 Regulation CALM3 TNF 17116732 1543371 Regulation CALU CD14 23936239 2829698 Regulation CAMK2A RINL 22291991 2591595 Regulation CAMP MMP28 22336948 1630692 Regulation CAMP MMP7 22336948 1630707 Regulation CAMP TLR7 19703986 1556012 Regulation CANX EPHB2 24330599 388952 Regulation CANX EPHB2 24330599 388969 Regulation CANX EPHB2 24552586 389100 Regulation CANX EPHB2 25500906 2160849 Regulation CAPN1 CAPN8 20686710 2317443 Regulation CAPN10 CAPN8 20686710 2317445 Regulation CAPN11 CAPN8 20686710 2317447 Regulation CAPN12 CAPN8 20686710 2317441 Regulation CAPN13 CAPN8 20686710 2317463 Regulation CAPN14 CAPN8 20686710 2317465 Regulation CAPN15 CAPN8 20686710 2317439 Regulation CAPN2 CAPN8 16433929 298649 Regulation CAPN2 CAPN8 20686710 2317449 Regulation CAPN2 EPHB2 24611062 880297 Regulation CAPN3 CAPN8 20686710 2317451 Regulation CAPN5 CAPN8 20686710 2317453 Regulation CAPN6 CAPN8 20686710 2317455 Regulation CAPN7 CAPN8 20686710 2317457 Regulation CAPN8 APOB 18624772 1478973 Regulation CAPN8 CA2 18624772 1478972 Regulation CAPN8 CA2 18803809 1832789 Regulation CAPN8 CA2 20949071 3048942 Regulation CAPN8 CA2 21152086 2486170 Regulation CAPN8 CA2 21516125 2139268 Regulation CAPN8 CA2 21516125 2139269 Regulation CAPN8 CA2 21738275 1713164 Regulation CAPN8 CA2 22069695 3183486 Regulation CAPN8 CA2 22563421 2626425 Regulation CAPN8 CA2 22864302 15840 Regulation CAPN8 CA2 23596505 2781838 Regulation CAPN8 CA2 23734212 2799646 Regulation CAPN8 CA2 23865001 3092044 Regulation CAPN8 CA2 23865001 3092058 Regulation CAPN8 CA2 24416390 2908265 Regulation CAPN8 CA2 24567703 868797 Regulation CAPN8 CA2 24961530 452842 Regulation CAPN8 CA2 25352808 966566 Regulation CAPN8 CA2 25364642 452602 Regulation CAPN8 CA2 9456328 1466399 Regulation CAPN8 CALB1 24963283 842412 Regulation CAPN8 CALB1 24963283 842497 Regulation CAPN8 CAPN1 25110686 196281 Regulation CAPN8 CAPN2 16433929 298657 Regulation CAPN8 CAPN2 25110686 196282 Regulation CAPN8 CAPN8 20686710 2317459 Regulation CAPN8 CAPN9 20686710 2317460 Regulation CAPN8 CAPNS1 23349941 2744112 Regulation CAPN8 CAPNS1 25110686 196283 Regulation CAPN8 CAST 12904264 1843601 Regulation CAPN8 CAST 17083274 3039391 Regulation CAPN8 CAST 19761592 315389 Regulation CAPN8 CAST 21475693 1238330 Regulation CAPN8 CAST 21765948 2536584 Regulation CAPN8 CAST 22745213 90602 Regulation CAPN8 CAST 22829235 217974 Regulation CAPN8 CAST 23507938 588686 Regulation CAPN8 CAST 23507938 588687 Regulation CAPN8 CAST 23507938 588704 Regulation CAPN8 CAST 23899207 682446 Regulation CAPN8 CAST 8449989 1448924 Regulation CAPN8 CAST 9566966 1467173 Regulation CAPN8 CAST 9566966 1467174 Regulation CAPN8 CAST 9566966 1467290 Regulation CAPN8 CAST PMC2364211 450024 Regulation CAPN8 CXCL10 10402474 1248641 Regulation CAPN8 FLNA 20937704 1560991 Regulation CAPN8 HSP90AA1 25575026 3037369 Regulation CAPN8 KCNIP3 22518099 930524 Regulation CAPN8 LGALS3 21368866 550708 Regulation CAPN8 MAPK1 22808288 2665513 Regulation CAPN8 MAPK1 25079291 620626 Regulation CAPN8 MAPK10 22808288 2665514 Regulation CAPN8 MAPK10 25079291 620627 Regulation CAPN8 MAPK11 22808288 2665515 Regulation CAPN8 MAPK11 25079291 620628 Regulation CAPN8 MAPK12 22808288 2665516 Regulation CAPN8 MAPK12 25079291 620629 Regulation CAPN8 MAPK13 22808288 2665517 Regulation CAPN8 MAPK13 25079291 620630 Regulation CAPN8 MAPK14 22808288 2665518 Regulation CAPN8 MAPK14 25079291 620631 Regulation CAPN8 MAPK15 22808288 2665512 Regulation CAPN8 MAPK15 25079291 620625 Regulation CAPN8 MAPK3 22808288 2665519 Regulation CAPN8 MAPK3 25079291 620632 Regulation CAPN8 MAPK4 22808288 2665520 Regulation CAPN8 MAPK4 25079291 620633 Regulation CAPN8 MAPK6 22808288 2665521 Regulation CAPN8 MAPK6 25079291 620634 Regulation CAPN8 MAPK7 22808288 2665522 Regulation CAPN8 MAPK7 25079291 620635 Regulation CAPN8 MAPK8 22808288 2665523 Regulation CAPN8 MAPK8 25079291 620636 Regulation CAPN8 MAPK9 22808288 2665524 Regulation CAPN8 MAPK9 25079291 620637 Regulation CAPN8 MMP14 22407449 87057 Regulation CAPN8 PDGFB 24454980 2228034 Regulation CAPN8 PIN1 19545424 1625411 Regulation CAPN8 PIN1 19545424 1625425 Regulation CAPN8 PIN1 19545424 1625456 Regulation CAPN8 PIN1 19545424 1625489 Regulation CAPN8 PPARG 18657264 507863 Regulation CAPN8 PPARG 18657264 507877 Regulation CAPN8 PRKACB 10402474 1248265 Regulation CAPN8 PRKACB 10402474 1248477 Regulation CAPN8 PRKACB 12086590 369086 Regulation CAPN8 PRKACG 10402474 1248266 Regulation CAPN8 PRKACG 10402474 1248478 Regulation CAPN8 PRKACG 12086590 369087 Regulation CAPN8 PRKAR1A 10402474 1248267 Regulation CAPN8 PRKAR1A 10402474 1248479 Regulation CAPN8 PRKAR1A 12086590 369088 Regulation CAPN8 PRKAR1B 10402474 1248268 Regulation CAPN8 PRKAR1B 10402474 1248480 Regulation CAPN8 PRKAR1B 12086590 369089 Regulation CAPN8 PRKAR2A 10402474 1248269 Regulation CAPN8 PRKAR2A 10402474 1248481 Regulation CAPN8 PRKAR2A 12086590 369090 Regulation CAPN8 PRKAR2B 10402474 1248270 Regulation CAPN8 PRKAR2B 10402474 1248482 Regulation CAPN8 PRKAR2B 12086590 369091 Regulation CAPN8 PTPRC 23936270 2829854 Regulation CAPN8 RAPSN 18647419 384747 Regulation CAPN8 RBMS1 23922702 2826205 Regulation CAPN8 RBMS1 23922702 2826219 Regulation CAPN8 RBMS1 23922702 2826234 Regulation CAPN8 ROCK1 12486114 1290205 Regulation CAPN8 ROCK2 12486114 1290206 Regulation CAPN8 SLC9A1 12486114 1290207 Regulation CAPN8 TRPM7 21152086 2486221 Regulation CAPN8 TTBK1 24808823 931783 Regulation CAPN8 VDR 23696511 1029354 Regulation CAPN8 VEGFA 24886224 511587 Regulation CAPN9 CAPN8 20686710 2317461 Regulation CAPNS1 EPHB2 24611062 880298 Regulation CARD11 TLR7 22303480 2594897 Regulation CASP1 AXIN2 10496353 415373 Regulation CASP1 FAS 11696559 1276003 Regulation CASP1 FAS 22942738 1097178 Regulation CASP1 FAS 25426120 915270 Regulation CASP1 FAS 9730899 1603656 Regulation CASP1 FAS 9730899 1603657 Regulation CASP1 FAS 9730899 1603775 Regulation CASP1 FOXO1 20200974 1237344 Regulation CASP1 TNF 10704075 1736866 Regulation CASP1 TNF 19440308 2416545 Regulation CASP1 TNF 19440308 2416716 Regulation CASP1 TNF 19440308 2416755 Regulation CASP1 TNF 24762050 132304 Regulation CASP1 TNFSF10 17353365 1544776 Regulation CASP1 TNFSF10 17718901 1645608 Regulation CASP1 TNFSF10 17916240 1645779 Regulation CASP1 TNFSF10 20639907 2133088 Regulation CASP1 TNFSF10 21513580 1861758 Regulation CASP1 TNFSF10 21586138 1862056 Regulation CASP1 TNFSF10 21586138 1862057 Regulation CASP1 TNFSF10 21801359 260651 Regulation CASP1 TNFSF10 22735465 1140928 Regulation CASP1 TNFSF10 25349561 1147440 Regulation CASP1 TP63 23703390 561951 Regulation CASP10 FAS 11696559 1276004 Regulation CASP10 FAS 22942738 1097179 Regulation CASP10 FAS 25426120 915271 Regulation CASP10 FAS 9730899 1603658 Regulation CASP10 FAS 9730899 1603659 Regulation CASP10 FAS 9730899 1603776 Regulation CASP10 FOXO1 20200974 1237345 Regulation CASP10 TNF 10704075 1736867 Regulation CASP10 TNF 19440308 2416547 Regulation CASP10 TNF 19440308 2416718 Regulation CASP10 TNF 19440308 2416756 Regulation CASP10 TNFSF10 17353365 1544777 Regulation CASP10 TNFSF10 17718901 1645609 Regulation CASP10 TNFSF10 17916240 1645780 Regulation CASP10 TNFSF10 20639907 2133089 Regulation CASP10 TNFSF10 21513580 1861759 Regulation CASP10 TNFSF10 21586138 1862058 Regulation CASP10 TNFSF10 21586138 1862059 Regulation CASP10 TNFSF10 21801359 260652 Regulation CASP10 TNFSF10 22735465 1140929 Regulation CASP10 TNFSF10 25349561 1147441 Regulation CASP12 CAPN8 10953012 1262099 Regulation CASP12 CAPN8 10953012 1262169 Regulation CASP12 CAPN8 21525936 551820 Regulation CASP12 DAPK1 23114086 625151 Regulation CASP12 FAS 11696559 1276014 Regulation CASP12 FAS 22942738 1097189 Regulation CASP12 FAS 25426120 915281 Regulation CASP12 FAS 9730899 1603678 Regulation CASP12 FAS 9730899 1603679 Regulation CASP12 FAS 9730899 1603786 Regulation CASP12 FOXO1 20200974 1237355 Regulation CASP12 TNF 10704075 1736877 Regulation CASP12 TNF 19440308 2416567 Regulation CASP12 TNF 19440308 2416738 Regulation CASP12 TNF 19440308 2416766 Regulation CASP12 TNF 24920883 743110 Regulation CASP12 TNFSF10 17353365 1544787 Regulation CASP12 TNFSF10 17718901 1645619 Regulation CASP12 TNFSF10 17916240 1645790 Regulation CASP12 TNFSF10 20639907 2133099 Regulation CASP12 TNFSF10 21513580 1861769 Regulation CASP12 TNFSF10 21586138 1862078 Regulation CASP12 TNFSF10 21586138 1862079 Regulation CASP12 TNFSF10 21801359 260662 Regulation CASP12 TNFSF10 22735465 1140941 Regulation CASP12 TNFSF10 25349561 1147451 Regulation CASP14 FAS 11696559 1276005 Regulation CASP14 FAS 22942738 1097180 Regulation CASP14 FAS 25426120 915272 Regulation CASP14 FAS 9730899 1603660 Regulation CASP14 FAS 9730899 1603661 Regulation CASP14 FAS 9730899 1603777 Regulation CASP14 FOXO1 20200974 1237346 Regulation CASP14 TNF 10704075 1736868 Regulation CASP14 TNF 19440308 2416549 Regulation CASP14 TNF 19440308 2416720 Regulation CASP14 TNF 19440308 2416757 Regulation CASP14 TNFSF10 17353365 1544778 Regulation CASP14 TNFSF10 17718901 1645610 Regulation CASP14 TNFSF10 17916240 1645781 Regulation CASP14 TNFSF10 20639907 2133090 Regulation CASP14 TNFSF10 21513580 1861760 Regulation CASP14 TNFSF10 21586138 1862060 Regulation CASP14 TNFSF10 21586138 1862061 Regulation CASP14 TNFSF10 21801359 260653 Regulation CASP14 TNFSF10 22735465 1140930 Regulation CASP14 TNFSF10 25349561 1147442 Regulation CASP16 FAS 11696559 1276015 Regulation CASP16 FAS 22942738 1097190 Regulation CASP16 FAS 25426120 915282 Regulation CASP16 FAS 9730899 1603690 Regulation CASP16 FAS 9730899 1603691 Regulation CASP16 FAS 9730899 1603787 Regulation CASP16 FOXO1 20200974 1237356 Regulation CASP16 TNF 10704075 1736878 Regulation CASP16 TNF 19440308 2416569 Regulation CASP16 TNF 19440308 2416740 Regulation CASP16 TNF 19440308 2416767 Regulation CASP16 TNFSF10 17353365 1544788 Regulation CASP16 TNFSF10 17718901 1645624 Regulation CASP16 TNFSF10 17916240 1645791 Regulation CASP16 TNFSF10 20639907 2133100 Regulation CASP16 TNFSF10 21513580 1861770 Regulation CASP16 TNFSF10 21586138 1862080 Regulation CASP16 TNFSF10 21586138 1862081 Regulation CASP16 TNFSF10 21801359 260663 Regulation CASP16 TNFSF10 22735465 1140942 Regulation CASP16 TNFSF10 25349561 1147452 Regulation CASP2 FAS 11696559 1276006 Regulation CASP2 FAS 22942738 1097181 Regulation CASP2 FAS 25426120 915273 Regulation CASP2 FAS 9730899 1603662 Regulation CASP2 FAS 9730899 1603663 Regulation CASP2 FAS 9730899 1603778 Regulation CASP2 FOXO1 20200974 1237347 Regulation CASP2 TNF 10704075 1736869 Regulation CASP2 TNF 19440308 2416551 Regulation CASP2 TNF 19440308 2416722 Regulation CASP2 TNF 19440308 2416758 Regulation CASP2 TNFSF10 17353365 1544779 Regulation CASP2 TNFSF10 17718901 1645611 Regulation CASP2 TNFSF10 17916240 1645782 Regulation CASP2 TNFSF10 20639907 2133091 Regulation CASP2 TNFSF10 21513580 1861761 Regulation CASP2 TNFSF10 21586138 1862062 Regulation CASP2 TNFSF10 21586138 1862063 Regulation CASP2 TNFSF10 21801359 260654 Regulation CASP2 TNFSF10 22735465 1140931 Regulation CASP2 TNFSF10 25349561 1147443 Regulation CASP3 ANGPT1 24308939 1158717 Regulation CASP3 ANGPT1 24308939 1158718 Regulation CASP3 CAPN8 23425388 275311 Regulation CASP3 CAPN8 23425388 275749 Regulation CASP3 CAPN8 23467460 1713354 Regulation CASP3 CAPN8 25352693 1713691 Regulation CASP3 CLDN10 22361748 554977 Regulation CASP3 CLU 20019877 1910237 Regulation CASP3 CLU 20019877 1910238 Regulation CASP3 FAS 11696559 1276007 Regulation CASP3 FAS 22942738 1097182 Regulation CASP3 FAS 25426120 915274 Regulation CASP3 FAS 9730899 1603664 Regulation CASP3 FAS 9730899 1603665 Regulation CASP3 FAS 9730899 1603779 Regulation CASP3 FOXO1 16157701 1323945 Regulation CASP3 FOXO1 20200974 1237348 Regulation CASP3 LAMB3 22673183 471594 Regulation CASP3 LBP 24595452 2931325 Regulation CASP3 MAP2K6 23675062 1064495 Regulation CASP3 MAP2K6 24886705 1668165 Regulation CASP3 MAP2K6 24939055 1508119 Regulation CASP3 TNF 10704075 1736870 Regulation CASP3 TNF 10732775 416676 Regulation CASP3 TNF 19440308 2416553 Regulation CASP3 TNF 19440308 2416724 Regulation CASP3 TNF 19440308 2416759 Regulation CASP3 TNF 19818125 3091171 Regulation CASP3 TNF 20693346 716069 Regulation CASP3 TNF 22768286 2660445 Regulation CASP3 TNF 23193206 729948 Regulation CASP3 TNF 23202309 3184265 Regulation CASP3 TNF 23476127 3154116 Regulation CASP3 TNF 24296797 2235891 Regulation CASP3 TNF 24857910 1127042 Regulation CASP3 TNF 25419573 3029458 Regulation CASP3 TNF 25419573 3029460 Regulation CASP3 TNF 25443632 762685 Regulation CASP3 TNF 25443632 762689 Regulation CASP3 TNFSF10 17353365 1544780 Regulation CASP3 TNFSF10 17718901 1645612 Regulation CASP3 TNFSF10 17718901 1645626 Regulation CASP3 TNFSF10 17718901 1645698 Regulation CASP3 TNFSF10 17718901 1645713 Regulation CASP3 TNFSF10 17916240 1645783 Regulation CASP3 TNFSF10 20639907 2133092 Regulation CASP3 TNFSF10 21513580 1861762 Regulation CASP3 TNFSF10 21586138 1862064 Regulation CASP3 TNFSF10 21586138 1862065 Regulation CASP3 TNFSF10 21801359 260655 Regulation CASP3 TNFSF10 22723988 2655525 Regulation CASP3 TNFSF10 22733138 2147706 Regulation CASP3 TNFSF10 22735465 1140932 Regulation CASP3 TNFSF10 22735465 1140933 Regulation CASP3 TNFSF10 24745479 474725 Regulation CASP3 TNFSF10 24745479 474800 Regulation CASP3 TNFSF10 25349561 1147444 Regulation CASP3 ZFP57 24722354 2951228 Regulation CASP4 FAS 11696559 1276008 Regulation CASP4 FAS 22942738 1097183 Regulation CASP4 FAS 25426120 915275 Regulation CASP4 FAS 9730899 1603666 Regulation CASP4 FAS 9730899 1603667 Regulation CASP4 FAS 9730899 1603780 Regulation CASP4 FOXO1 20200974 1237349 Regulation CASP4 TNF 10704075 1736871 Regulation CASP4 TNF 19440308 2416555 Regulation CASP4 TNF 19440308 2416726 Regulation CASP4 TNF 19440308 2416760 Regulation CASP4 TNFSF10 17353365 1544781 Regulation CASP4 TNFSF10 17718901 1645613 Regulation CASP4 TNFSF10 17916240 1645784 Regulation CASP4 TNFSF10 20639907 2133093 Regulation CASP4 TNFSF10 21513580 1861763 Regulation CASP4 TNFSF10 21586138 1862066 Regulation CASP4 TNFSF10 21586138 1862067 Regulation CASP4 TNFSF10 21801359 260656 Regulation CASP4 TNFSF10 22735465 1140934 Regulation CASP4 TNFSF10 25349561 1147445 Regulation CASP5 FAS 11696559 1276009 Regulation CASP5 FAS 22942738 1097184 Regulation CASP5 FAS 25426120 915276 Regulation CASP5 FAS 9730899 1603668 Regulation CASP5 FAS 9730899 1603669 Regulation CASP5 FAS 9730899 1603781 Regulation CASP5 FOXO1 20200974 1237350 Regulation CASP5 TNF 10704075 1736872 Regulation CASP5 TNF 19440308 2416557 Regulation CASP5 TNF 19440308 2416728 Regulation CASP5 TNF 19440308 2416761 Regulation CASP5 TNFSF10 17353365 1544782 Regulation CASP5 TNFSF10 17718901 1645614 Regulation CASP5 TNFSF10 17916240 1645785 Regulation CASP5 TNFSF10 20639907 2133094 Regulation CASP5 TNFSF10 21513580 1861764 Regulation CASP5 TNFSF10 21586138 1862068 Regulation CASP5 TNFSF10 21586138 1862069 Regulation CASP5 TNFSF10 21801359 260657 Regulation CASP5 TNFSF10 22735465 1140935 Regulation CASP5 TNFSF10 25349561 1147446 Regulation CASP6 FAS 11696559 1276010 Regulation CASP6 FAS 22942738 1097185 Regulation CASP6 FAS 25426120 915277 Regulation CASP6 FAS 9730899 1603670 Regulation CASP6 FAS 9730899 1603671 Regulation CASP6 FAS 9730899 1603782 Regulation CASP6 FOXO1 20200974 1237351 Regulation CASP6 TNF 10704075 1736873 Regulation CASP6 TNF 19440308 2416559 Regulation CASP6 TNF 19440308 2416730 Regulation CASP6 TNF 19440308 2416762 Regulation CASP6 TNFSF10 17353365 1544783 Regulation CASP6 TNFSF10 17718901 1645615 Regulation CASP6 TNFSF10 17916240 1645786 Regulation CASP6 TNFSF10 20639907 2133095 Regulation CASP6 TNFSF10 21513580 1861765 Regulation CASP6 TNFSF10 21586138 1862070 Regulation CASP6 TNFSF10 21586138 1862071 Regulation CASP6 TNFSF10 21801359 260658 Regulation CASP6 TNFSF10 22735465 1140936 Regulation CASP6 TNFSF10 25349561 1147447 Regulation CASP7 ANGPT1 24308939 1158719 Regulation CASP7 ANGPT1 24308939 1158720 Regulation CASP7 FAS 11696559 1276011 Regulation CASP7 FAS 22942738 1097186 Regulation CASP7 FAS 25426120 915278 Regulation CASP7 FAS 9730899 1603672 Regulation CASP7 FAS 9730899 1603673 Regulation CASP7 FAS 9730899 1603783 Regulation CASP7 FOXO1 20200974 1237352 Regulation CASP7 TNF 10704075 1736874 Regulation CASP7 TNF 19440308 2416561 Regulation CASP7 TNF 19440308 2416732 Regulation CASP7 TNF 19440308 2416763 Regulation CASP7 TNF 20693346 716071 Regulation CASP7 TNF 23193206 729950 Regulation CASP7 TNFSF10 17353365 1544784 Regulation CASP7 TNFSF10 17718901 1645616 Regulation CASP7 TNFSF10 17916240 1645787 Regulation CASP7 TNFSF10 20639907 2133096 Regulation CASP7 TNFSF10 21513580 1861766 Regulation CASP7 TNFSF10 21586138 1862072 Regulation CASP7 TNFSF10 21586138 1862073 Regulation CASP7 TNFSF10 21801359 260659 Regulation CASP7 TNFSF10 22735465 1140937 Regulation CASP7 TNFSF10 24745479 474726 Regulation CASP7 TNFSF10 24745479 474801 Regulation CASP7 TNFSF10 25349561 1147448 Regulation CASP8 ANGPT1 23554782 1226185 Regulation CASP8 FAS 11181697 1518438 Regulation CASP8 FAS 11696559 1276012 Regulation CASP8 FAS 11857024 420549 Regulation CASP8 FAS 16129703 1537086 Regulation CASP8 FAS 18725521 1551762 Regulation CASP8 FAS 19936090 981593 Regulation CASP8 FAS 22942738 1097187 Regulation CASP8 FAS 23986795 2220498 Regulation CASP8 FAS 25426120 915279 Regulation CASP8 FAS 9730899 1603674 Regulation CASP8 FAS 9730899 1603675 Regulation CASP8 FAS 9730899 1603784 Regulation CASP8 FOXO1 20200974 1237353 Regulation CASP8 TNF 10704075 1736875 Regulation CASP8 TNF 11696595 1521651 Regulation CASP8 TNF 18638380 1722737 Regulation CASP8 TNF 18638380 1722743 Regulation CASP8 TNF 19440308 2416563 Regulation CASP8 TNF 19440308 2416734 Regulation CASP8 TNF 19440308 2416764 Regulation CASP8 TNF 19818125 3091172 Regulation CASP8 TNF 20920299 481709 Regulation CASP8 TNF 21103379 2483896 Regulation CASP8 TNF 22768286 2660446 Regulation CASP8 TNF 25053988 986907 Regulation CASP8 TNF 25053988 986909 Regulation CASP8 TNF 25216531 2199947 Regulation CASP8 TNF 25443632 762686 Regulation CASP8 TNF 25443632 762690 Regulation CASP8 TNFSF10 17353365 1544785 Regulation CASP8 TNFSF10 17718901 1645617 Regulation CASP8 TNFSF10 17718901 1645681 Regulation CASP8 TNFSF10 17718901 1645699 Regulation CASP8 TNFSF10 17916240 1645788 Regulation CASP8 TNFSF10 20062539 2436812 Regulation CASP8 TNFSF10 20639907 2133097 Regulation CASP8 TNFSF10 21368884 551049 Regulation CASP8 TNFSF10 21513580 1861767 Regulation CASP8 TNFSF10 21586138 1862074 Regulation CASP8 TNFSF10 21586138 1862075 Regulation CASP8 TNFSF10 21801359 260660 Regulation CASP8 TNFSF10 22735465 1140938 Regulation CASP8 TNFSF10 22735465 1140939 Regulation CASP8 TNFSF10 23348591 559342 Regulation CASP8 TNFSF10 24927176 2980175 Regulation CASP8 TNFSF10 25349561 1147449 Regulation CASP9 FAS 11696559 1276013 Regulation CASP9 FAS 22942738 1097188 Regulation CASP9 FAS 25426120 915280 Regulation CASP9 FAS 9730899 1603676 Regulation CASP9 FAS 9730899 1603677 Regulation CASP9 FAS 9730899 1603785 Regulation CASP9 FOXO1 20200974 1237354 Regulation CASP9 LBP 24595452 2931322 Regulation CASP9 TNF 10704075 1736876 Regulation CASP9 TNF 19440308 2416565 Regulation CASP9 TNF 19440308 2416736 Regulation CASP9 TNF 19440308 2416765 Regulation CASP9 TNF 23193206 729952 Regulation CASP9 TNF 25419573 3029462 Regulation CASP9 TNFSF10 17353365 1544786 Regulation CASP9 TNFSF10 17718901 1645618 Regulation CASP9 TNFSF10 17718901 1645700 Regulation CASP9 TNFSF10 17916240 1645789 Regulation CASP9 TNFSF10 20639907 2133098 Regulation CASP9 TNFSF10 21513580 1861768 Regulation CASP9 TNFSF10 21586138 1862076 Regulation CASP9 TNFSF10 21586138 1862077 Regulation CASP9 TNFSF10 21801359 260661 Regulation CASP9 TNFSF10 22735465 1140940 Regulation CASP9 TNFSF10 25349561 1147450 Regulation CASR GPR115 24040082 2845459 Regulation CASR GPR132 24040082 2845448 Regulation CASR GPR87 24040082 2845528 Regulation CAST CAPN8 12904264 1843613 Regulation CAST CAPN8 18706097 291413 Regulation CAST CAPN8 21475693 1238342 Regulation CAST CAPN8 23899207 682458 Regulation CAT FOXO1 23950968 2833051 Regulation CAT FOXO1 23950968 2833060 Regulation CAT FOXO1 24265619 962832 Regulation CAT MAP2K6 8707830 1453809 Regulation CAT OSR1 25206429 2004408 Regulation CAT TNF 2109037 1561574 Regulation CAV1 CTGF 25328554 2220234 Regulation CAV1 EPHB2 24119769 1700725 Regulation CAV1 EPHB2 24119769 1700739 Regulation CBFA2T2 PECAM1 20723025 1692080 Regulation CBFA2T2 PECAM1 20723025 1692088 Regulation CBL CTGF 23175185 548174 Regulation CBL NGFR 22880054 2673891 Regulation CBX4 EPHB2 22870894 802976 Regulation CBY1 TCN1 22958914 266250 Regulation CBY3 TCN1 22958914 266251 Regulation CCDC88A FAS 23967134 2834586 Regulation CCL1 LINC00284 25431574 918996 Regulation CCL1 LINC00341 25431574 918956 Regulation CCL15 TNF 23258953 1751107 Regulation CCL17 CCL1 24278618 3180332 Regulation CCL17 CCL13 24278618 3180333 Regulation CCL17 CCL2 24278618 3180334 Regulation CCL17 CCL5 24278618 3180335 Regulation CCL17 DTX1 24489574 639545 Regulation CCL17 DTX1 24489574 639564 Regulation CCL17 DTX1 24489574 639565 Regulation CCL17 DTX2 24489574 639542 Regulation CCL17 DTX2 24489574 639558 Regulation CCL17 DTX2 24489574 639559 Regulation CCL17 DTX3 24489574 639543 Regulation CCL17 DTX3 24489574 639560 Regulation CCL17 DTX3 24489574 639561 Regulation CCL17 DTX4 24489574 639544 Regulation CCL17 DTX4 24489574 639562 Regulation CCL17 DTX4 24489574 639563 Regulation CCL17 IL22 21789181 2537918 Regulation CCL17 TSLP 23435120 1958535 Regulation CCL17 TSLP 23437132 2755722 Regulation CCL18 TNF 17875202 109079 Regulation CCL18 TNF 17875202 109085 Regulation CCL18 TNF 17875202 109091 Regulation CCL2 EDN2 20937084 1657168 Regulation CCL2 EFNB1 24098442 2856377 Regulation CCL2 EPHB2 21966476 2559071 Regulation CCL2 EPHB2 24782592 1758331 Regulation CCL2 F2R 18606855 1551551 Regulation CCL2 F2R 22992722 988761 Regulation CCL2 F2R 22992722 988765 Regulation CCL2 F2R 22992722 988780 Regulation CCL2 F2R 24385683 1756396 Regulation CCL2 PECAM1 22641100 1718359 Regulation CCL2 RGS2 21494556 2513025 Regulation CCL2 RGS2 21494556 2513027 Regulation CCL2 RGS2 21494556 2513028 Regulation CCL2 S100B 23864876 638035 Regulation CCL2 TLR7 19047436 1552979 Regulation CCL2 TNF 15631627 3104184 Regulation CCL2 TNF 16091136 3105633 Regulation CCL2 TNF 17542648 2304109 Regulation CCL2 TNF 18472920 1743150 Regulation CCL2 TNF 18472920 1743153 Regulation CCL2 TNF 19936231 2431760 Regulation CCL2 TNF 22132330 1155368 Regulation CCL2 TNF 22414048 1626497 Regulation CCL2 TNF 22479654 2371259 Regulation CCL2 TNF 22692455 1918914 Regulation CCL2 TNF 22701457 901681 Regulation CCL2 TNF 22973275 904318 Regulation CCL2 TNF 23364987 3233055 Regulation CCL2 TNF 24064574 2118088 Regulation CCL2 TNF 24130892 2867515 Regulation CCL2 TNF 24371376 1756051 Regulation CCL2 TNF 24915004 2979091 Regulation CCL2 TNF 24920309 1668202 Regulation CCL2 TNF PMC4036662 2246692 Regulation CCL2 TP63 22606349 2643324 Regulation CCL20 TNF 21881590 1630497 Regulation CCL20 TNF 21881590 1630498 Regulation CCL20 TNF 21881590 1630499 Regulation CCL20 TNF 21881590 1630500 Regulation CCL20 TNF 23238132 651899 Regulation CCL20 TNF 23283206 3225511 Regulation CCL20 TNF 23283206 3225512 Regulation CCL20 TNF 23283206 3225513 Regulation CCL20 TNF 23283206 3225514 Regulation CCL20 TNF 23283206 3225515 Regulation CCL20 TNF 23800251 1627081 Regulation CCL20 TNF 23800251 1627082 Regulation CCL20 TNF 23800251 1627105 Regulation CCL20 TNF 23800251 1627106 Regulation CCL20 TNF 23800251 1627125 Regulation CCL20 TNF 23800251 1627144 Regulation CCL20 TNF 23800251 1627177 Regulation CCL20 TNF 23824685 2809245 Regulation CCL20 TNF 23874340 908237 Regulation CCL20 TNF 24562309 1959948 Regulation CCL23 TNF 23283206 3225520 Regulation CCL23 TNF 23283206 3225521 Regulation CCL23 TNF 23283206 3225522 Regulation CCL23 TNF 23283206 3225523 Regulation CCL23 TNF 23283206 3225524 Regulation CCL23 TNF 23331383 1675420 Regulation CCL23 TNF 23331383 1675421 Regulation CCL28 AGR2 22174895 2582477 Regulation CCL4 TNF 24892615 653895 Regulation CCL5 TNF 22738652 1621041 Regulation CCL5 TNF 24371376 1756052 Regulation CCL5 TNF 24523572 1757467 Regulation CCL5 TNF 24523572 1757469 Regulation CCL7 MIP 7507512 1588939 Regulation CCNA2 ID1 22139302 1879331 Regulation CCNA2 ID1 22139302 1879332 Regulation CCNA2 ID1 22139302 1879370 Regulation CCNA2 ID1 22139302 1879371 Regulation CCNA2 ID1 22139302 1879441 Regulation CCNA2 ID1 22139302 1879461 Regulation CCNA2 IFI27 23055977 959149 Regulation CCNB1 CCND1 20644552 10450 Regulation CCNB1 CCND1 22428049 2611355 Regulation CCNB1 MAP2K6 21170361 2320503 Regulation CCNC EPHB2 22319481 860875 Regulation CCNC EPHB2 23209347 1750868 Regulation CCNC EPHB2 24065881 931212 Regulation CCNC MAP2K6 24065881 931218 Regulation CCNC RCAN1 19124655 1553437 Regulation CCNC TF PMC3611773 1616043 Regulation CCNC TLR7 18584038 3073206 Regulation CCNC TLR7 18584038 3073937 Regulation CCNC TNF 23824685 2809215 Regulation CCNC TNF 25275456 2373055 Regulation CCNC TNF 3435705 443435 Regulation CCND1 AHSA1 22404972 528332 Regulation CCND1 AHSA1 22404972 528338 Regulation CCND1 AKT1 12835312 1293376 Regulation CCND1 AKT1 20113529 1853272 Regulation CCND1 AKT1 20414334 1066292 Regulation CCND1 AKT1 22359572 2597702 Regulation CCND1 AKT1 22481935 1673569 Regulation CCND1 AKT1 22799881 265302 Regulation CCND1 AKT1 23300886 2737099 Regulation CCND1 AKT1 23383143 2748418 Regulation CCND1 AKT1 23511556 440329 Regulation CCND1 AKT1 23533654 2771110 Regulation CCND1 AKT1 23552696 2156334 Regulation CCND1 AKT1 23895220 269527 Regulation CCND1 AKT1 23951180 2833654 Regulation CCND1 AKT1 24098737 2859509 Regulation CCND1 AKT1 24577313 1124459 Regulation CCND1 AKT1 24968355 2984345 Regulation CCND1 AKT1 24970807 2193944 Regulation CCND1 AKT2 12835312 1293377 Regulation CCND1 AKT2 20113529 1853273 Regulation CCND1 AKT2 20414334 1066293 Regulation CCND1 AKT2 22359572 2597703 Regulation CCND1 AKT2 22481935 1673570 Regulation CCND1 AKT2 22799881 265303 Regulation CCND1 AKT2 23300886 2737100 Regulation CCND1 AKT2 23383143 2748419 Regulation CCND1 AKT2 23511556 440330 Regulation CCND1 AKT2 23533654 2771111 Regulation CCND1 AKT2 23552696 2156335 Regulation CCND1 AKT2 23895220 269528 Regulation CCND1 AKT2 23951180 2833655 Regulation CCND1 AKT2 24098737 2859510 Regulation CCND1 AKT2 24577313 1124460 Regulation CCND1 AKT2 24968355 2984346 Regulation CCND1 AKT2 24970807 2193945 Regulation CCND1 AKT3 12835312 1293378 Regulation CCND1 AKT3 20113529 1853274 Regulation CCND1 AKT3 20414334 1066294 Regulation CCND1 AKT3 22359572 2597704 Regulation CCND1 AKT3 22481935 1673571 Regulation CCND1 AKT3 22799881 265304 Regulation CCND1 AKT3 23300886 2737101 Regulation CCND1 AKT3 23383143 2748420 Regulation CCND1 AKT3 23511556 440331 Regulation CCND1 AKT3 23533654 2771112 Regulation CCND1 AKT3 23552696 2156336 Regulation CCND1 AKT3 23895220 269529 Regulation CCND1 AKT3 23951180 2833656 Regulation CCND1 AKT3 24098737 2859511 Regulation CCND1 AKT3 24577313 1124461 Regulation CCND1 AKT3 24968355 2984347 Regulation CCND1 AKT3 24970807 2193946 Regulation CCND1 ANGPT2 20037604 8675 Regulation CCND1 ANGPT2 20037604 8676 Regulation CCND1 ARHGEF2 19730435 785918 Regulation CCND1 ARHGEF2 19730435 785919 Regulation CCND1 ARHGEF2 19730435 785944 Regulation CCND1 ATF2 16984628 370058 Regulation CCND1 ATF2 22404972 528340 Regulation CCND1 ATF2 22404972 528357 Regulation CCND1 ATF2 22919439 2224665 Regulation CCND1 ATF3 22046379 2567180 Regulation CCND1 ATF3 23591848 1105889 Regulation CCND1 ATM 23776433 2804252 Regulation CCND1 ATM 23776433 2804272 Regulation CCND1 ATM 23776433 2804285 Regulation CCND1 ATM 23776433 2804287 Regulation CCND1 ATM 23776433 2804291 Regulation CCND1 ATP2A2 22763406 984412 Regulation CCND1 BANP 17726044 2030291 Regulation CCND1 BCL10 21151996 2485700 Regulation CCND1 BCL6 24917186 273856 Regulation CCND1 BCLAF1 18053169 1242802 Regulation CCND1 BCLAF1 22833098 557271 Regulation CCND1 BEX2 20482821 1855202 Regulation CCND1 BEX2 20482821 1855272 Regulation CCND1 BTG2 24744701 869137 Regulation CCND1 CALM3 17092340 580189 Regulation CCND1 CAPN1 17407548 1846343 Regulation CCND1 CAPN10 17407548 1846344 Regulation CCND1 CAPN11 17407548 1846345 Regulation CCND1 CAPN12 17407548 1846341 Regulation CCND1 CAPN13 17407548 1846353 Regulation CCND1 CAPN14 17407548 1846354 Regulation CCND1 CAPN15 17407548 1846340 Regulation CCND1 CAPN2 17407548 1846346 Regulation CCND1 CAPN3 17407548 1846347 Regulation CCND1 CAPN5 17407548 1846348 Regulation CCND1 CAPN6 17407548 1846349 Regulation CCND1 CAPN7 17407548 1846350 Regulation CCND1 CAPN8 17407548 1846351 Regulation CCND1 CAPN9 17407548 1846352 Regulation CCND1 CARM1 19725955 302663 Regulation CCND1 CARM1 19725955 302664 Regulation CCND1 CARM1 19725955 302665 Regulation CCND1 CARM1 19725955 302676 Regulation CCND1 CARM1 19725955 302685 Regulation CCND1 CAV1 23521716 1480104 Regulation CCND1 CCL21 21698152 2530523 Regulation CCND1 CCNB1 20644552 10452 Regulation CCND1 CCNB1 22428049 2611356 Regulation CCND1 CCND1 25486524 2160767 Regulation CCND1 CD44 17296798 1337099 Regulation CCND1 CD44 17296798 1337100 Regulation CCND1 CD44 17296798 1337102 Regulation CCND1 CD44 17296798 1337119 Regulation CCND1 CDC73 19906718 2048298 Regulation CCND1 CDC73 19906718 2048299 Regulation CCND1 CDC73 19906718 2048346 Regulation CCND1 CDC73 22043238 1239563 Regulation CCND1 CDK2 23469073 2761197 Regulation CCND1 CDK4 23383245 2749737 Regulation CCND1 CDK4 24074866 517547 Regulation CCND1 CDK4 25486524 2160768 Regulation CCND1 CDK4 25593996 2173488 Regulation CCND1 CDK6 23383245 2749738 Regulation CCND1 CDK6 25486524 2160769 Regulation CCND1 CDKN1A 22087289 2571294 Regulation CCND1 CDKN1A 23638178 2787819 Regulation CCND1 CDKN1A 25077542 577955 Regulation CCND1 CDKN2A 22860097 2671599 Regulation CCND1 CEND1 24312406 2889219 Regulation CCND1 CEND1 24312406 2889252 Regulation CCND1 CNTN2 20101207 2128741 Regulation CCND1 CPD 23950841 2832619 Regulation CCND1 CPE 24006921 269683 Regulation CCND1 CPE 24006921 269684 Regulation CCND1 CREB1 16984628 370056 Regulation CCND1 CREB1 22404972 528355 Regulation CCND1 CREB3 16984628 370057 Regulation CCND1 CREB3 22404972 528356 Regulation CCND1 CREB5 16984628 370055 Regulation CCND1 CREB5 22404972 528354 Regulation CCND1 CSE 20429916 3110340 Regulation CCND1 CTNND1 24979278 2160524 Regulation CCND1 CTNND1 24979278 2160526 Regulation CCND1 CTSS 16504004 1845179 Regulation CCND1 CYBB 21394106 487502 Regulation CCND1 CYLD 19124656 1553518 Regulation CCND1 CYLD 19124656 1553519 Regulation CCND1 CYLD 19124656 1553520 Regulation CCND1 CYLD 19124656 1553556 Regulation CCND1 DDRGK1 23675531 2793559 Regulation CCND1 DDRGK1 23675531 2793561 Regulation CCND1 DNM1 23425318 3187375 Regulation CCND1 DNM2 23425318 3187376 Regulation CCND1 DNM3 23425318 3187374 Regulation CCND1 DYRK1B 24312406 2889209 Regulation CCND1 DYRK1B 24312406 2889220 Regulation CCND1 DYRK1B 24312406 2889253 Regulation CCND1 DYRK1B 24312406 2889263 Regulation CCND1 E2F1 21799732 2538393 Regulation CCND1 EEF2K 22911754 2676264 Regulation CCND1 EGF 16984645 279328 Regulation CCND1 EGF 19168569 3180644 Regulation CCND1 EGF 22927910 2680955 Regulation CCND1 EGFR 19529774 2419452 Regulation CCND1 EGFR 19935697 2128223 Regulation CCND1 EGFR 19935697 2128224 Regulation CCND1 EGFR 19935697 2128244 Regulation CCND1 EGFR 19935697 2128318 Regulation CCND1 EGFR 20092659 1504034 Regulation CCND1 EGFR 20302655 1853771 Regulation CCND1 EGFR 22117530 262692 Regulation CCND1 EGFR 24340049 2894771 Regulation CCND1 EGFR 24499623 1507740 Regulation CCND1 EGFR 24499623 1507741 Regulation CCND1 EGI 24971752 2984983 Regulation CCND1 EGLN2 24858415 607105 Regulation CCND1 EIF4E 18498250 146255 Regulation CCND1 ELAVL1 23242178 477785 Regulation CCND1 EPCAM 23830302 399216 Regulation CCND1 EPHB2 17205132 2374392 Regulation CCND1 EPHB2 22833568 1806103 Regulation CCND1 EPHB2 22833568 1806104 Regulation CCND1 EPHB2 22833568 1806105 Regulation CCND1 EPHB2 22870237 2672086 Regulation CCND1 EPHB2 23268747 587774 Regulation CCND1 EPHB2 23300886 2737098 Regulation CCND1 EPHB2 23792647 479004 Regulation CCND1 EPHB2 23895220 269526 Regulation CCND1 EPHB2 24577313 1124458 Regulation CCND1 EPHB2 24970807 2193943 Regulation CCND1 EPHB2 25015194 2195697 Regulation CCND1 ERBB2 24765191 2168353 Regulation CCND1 ERBB3 23951180 2833650 Regulation CCND1 ERBB3 23951180 2833653 Regulation CCND1 ERBB3 23951180 2833664 Regulation CCND1 ESR1 16863592 580010 Regulation CCND1 ETS1 23268747 587775 Regulation CCND1 ETS2 23268747 587776 Regulation CCND1 EYA1 19606213 2421625 Regulation CCND1 EZH2 23949225 564864 Regulation CCND1 EZH2 25038756 496453 Regulation CCND1 FABP4 24312381 2889039 Regulation CCND1 FABP4 24312381 2889051 Regulation CCND1 FABP4 24312381 2889092 Regulation CCND1 FBXL2 22020328 2144306 Regulation CCND1 FBXO4 17407548 1846342 Regulation CCND1 FBXO4 18764945 583293 Regulation CCND1 FBXW8 17205132 2374346 Regulation CCND1 FBXW8 17205132 2374390 Regulation CCND1 FBXW8 17205132 2374406 Regulation CCND1 FGF2 21394106 487515 Regulation CCND1 FGF23 18678710 1354317 Regulation CCND1 FGF3 18703590 2035918 Regulation CCND1 FOXO3 22815774 2665995 Regulation CCND1 FOXO3 24886554 1874867 Regulation CCND1 FUT1 24056538 3137250 Regulation CCND1 FUT1 24056538 3137262 Regulation CCND1 GAS1 22276155 2590229 Regulation CCND1 GAST 15798764 425448 Regulation CCND1 GATA4 23558708 3126610 Regulation CCND1 GATA4 23558708 3126611 Regulation CCND1 GDF11 24244313 2879265 Regulation CCND1 GDF15 14757751 1305499 Regulation CCND1 GDNF 24603431 2357224 Regulation CCND1 GHRH 25484899 1074964 Regulation CCND1 GJA1 24056538 3137245 Regulation CCND1 GJA1 24056538 3137251 Regulation CCND1 GJA1 24056538 3137269 Regulation CCND1 GLI1 22799764 265279 Regulation CCND1 GLI1 22900095 2675219 Regulation CCND1 GLIS1 24598114 1618736 Regulation CCND1 GLIS2 24598114 1618735 Regulation CCND1 GLIS3 24598114 1618734 Regulation CCND1 GRAP2 16351709 1844998 Regulation CCND1 HACE1 23864022 1937157 Regulation CCND1 HACE1 23864022 1937158 Regulation CCND1 HACE1 23864022 1937159 Regulation CCND1 HDAC1 22639737 798275 Regulation CCND1 HDAC1 22639737 798283 Regulation CCND1 HDAC2 22639737 798276 Regulation CCND1 HDAC2 22639737 798284 Regulation CCND1 HGF 22404972 528339 Regulation CCND1 HIST1H3H 25409181 3028401 Regulation CCND1 HIST1H3H 25409181 3028471 Regulation CCND1 HIST1H3H 25409181 3028542 Regulation CCND1 HNF4A 22751438 541617 Regulation CCND1 HNRNPD 21799732 2538390 Regulation CCND1 HNRNPD 23242178 477786 Regulation CCND1 HPGDS 23426146 2163672 Regulation CCND1 HPR 20537156 1855700 Regulation CCND1 HRAS 23268747 587777 Regulation CCND1 HSP90AA1 20398364 1853914 Regulation CCND1 ID1 24137437 2165749 Regulation CCND1 ID2 22835384 624964 Regulation CCND1 IGF1 14676301 1530309 Regulation CCND1 IGF1 17200689 1054578 Regulation CCND1 IGF1 17200689 1054579 Regulation CCND1 IGF1 19865540 1088912 Regulation CCND1 IGF2 14676301 1530310 Regulation CCND1 IL6 19440292 2416418 Regulation CCND1 ILK 11402061 1270967 Regulation CCND1 ILK 11402061 1270970 Regulation CCND1 ILK 11402061 1271016 Regulation CCND1 ILK 12835312 1293327 Regulation CCND1 ILK 12835312 1293379 Regulation CCND1 ILK 12835312 1293384 Regulation CCND1 ILK 20565980 465635 Regulation CCND1 ILK 24024606 314603 Regulation CCND1 INS 22253696 2587655 Regulation CCND1 INS 24870244 1991506 Regulation CCND1 INS 24870244 1991507 Regulation CCND1 INS 24870244 1991521 Regulation CCND1 IRF1 21197417 549241 Regulation CCND1 IRF1 21368870 550811 Regulation CCND1 IRS2 21532614 12716 Regulation CCND1 ISL1 21829621 2542088 Regulation CCND1 ISL1 21829621 2542111 Regulation CCND1 ISL1 21829621 2542116 Regulation CCND1 JAK1 23300886 2737102 Regulation CCND1 JAK2 20639901 2132986 Regulation CCND1 JAK2 23300886 2737103 Regulation CCND1 JAK2 24004818 1618327 Regulation CCND1 JAK2 24913037 273790 Regulation CCND1 JAK3 23300886 2737104 Regulation CCND1 JUN 23268747 587778 Regulation CCND1 JUN 24708856 1873765 Regulation CCND1 JUNB 20433688 255887 Regulation CCND1 KIDINS220 25410904 1884361 Regulation CCND1 KIN 25120685 2169288 Regulation CCND1 KITLG 17205132 2374347 Regulation CCND1 KL 18678710 1354318 Regulation CCND1 KLF5 20037604 8627 Regulation CCND1 KLF5 20037604 8628 Regulation CCND1 KLF5 20037604 8629 Regulation CCND1 KLF5 20037604 8630 Regulation CCND1 KLF5 20037604 8631 Regulation CCND1 KLF5 20037604 8677 Regulation CCND1 KLF8 23222713 2151183 Regulation CCND1 KMT2A 24288367 2096310 Regulation CCND1 KRAS 23268747 587779 Regulation CCND1 LEF1 11604417 1275705 Regulation CCND1 LEF1 16990252 2022810 Regulation CCND1 LEF1 17344318 2026680 Regulation CCND1 LEF1 22168911 3207480 Regulation CCND1 LEP 19531256 464479 Regulation CCND1 LILRB1 24281003 442575 Regulation CCND1 LMO4 19648968 2126257 Regulation CCND1 MALT1 21151996 2485699 Regulation CCND1 MAP2K1 17407548 1846317 Regulation CCND1 MAP2K1 19165201 431715 Regulation CCND1 MAP2K1 22833568 1806106 Regulation CCND1 MAP2K1 22833568 1806107 Regulation CCND1 MAP2K1 22833568 1806108 Regulation CCND1 MAP2K1 23268747 587780 Regulation CCND1 MAP2K1 23300886 2737105 Regulation CCND1 MAP2K2 17407548 1846318 Regulation CCND1 MAP2K2 19165201 431716 Regulation CCND1 MAP2K2 22833568 1806109 Regulation CCND1 MAP2K2 22833568 1806110 Regulation CCND1 MAP2K2 22833568 1806111 Regulation CCND1 MAP2K2 23268747 587781 Regulation CCND1 MAP2K2 23300886 2737106 Regulation CCND1 MAP2K3 17407548 1846319 Regulation CCND1 MAP2K3 19165201 431717 Regulation CCND1 MAP2K3 22833568 1806112 Regulation CCND1 MAP2K3 22833568 1806113 Regulation CCND1 MAP2K3 22833568 1806114 Regulation CCND1 MAP2K3 23268747 587782 Regulation CCND1 MAP2K3 23300886 2737107 Regulation CCND1 MAP2K4 17407548 1846320 Regulation CCND1 MAP2K4 19165201 431718 Regulation CCND1 MAP2K4 22833568 1806115 Regulation CCND1 MAP2K4 22833568 1806116 Regulation CCND1 MAP2K4 22833568 1806117 Regulation CCND1 MAP2K4 23268747 587783 Regulation CCND1 MAP2K4 23300886 2737108 Regulation CCND1 MAP2K5 17407548 1846321 Regulation CCND1 MAP2K5 19165201 431719 Regulation CCND1 MAP2K5 22833568 1806118 Regulation CCND1 MAP2K5 22833568 1806119 Regulation CCND1 MAP2K5 22833568 1806120 Regulation CCND1 MAP2K5 23268747 587784 Regulation CCND1 MAP2K5 23300886 2737109 Regulation CCND1 MAP2K6 17407548 1846322 Regulation CCND1 MAP2K6 19165201 431720 Regulation CCND1 MAP2K6 22833568 1806121 Regulation CCND1 MAP2K6 22833568 1806122 Regulation CCND1 MAP2K6 22833568 1806123 Regulation CCND1 MAP2K6 23268747 587785 Regulation CCND1 MAP2K6 23300886 2737110 Regulation CCND1 MAP2K7 17407548 1846323 Regulation CCND1 MAP2K7 19165201 431721 Regulation CCND1 MAP2K7 22833568 1806124 Regulation CCND1 MAP2K7 22833568 1806125 Regulation CCND1 MAP2K7 22833568 1806126 Regulation CCND1 MAP2K7 23268747 587786 Regulation CCND1 MAP2K7 23300886 2737111 Regulation CCND1 MAPK1 17205132 2374393 Regulation CCND1 MAPK1 17407548 1846337 Regulation CCND1 MAPK1 19159010 1055232 Regulation CCND1 MAPK1 20113529 1853275 Regulation CCND1 MAPK1 25077542 577957 Regulation CCND1 MAPK10 17205132 2374394 Regulation CCND1 MAPK10 19159010 1055233 Regulation CCND1 MAPK10 20113529 1853276 Regulation CCND1 MAPK10 25077542 577958 Regulation CCND1 MAPK11 17205132 2374395 Regulation CCND1 MAPK11 17407548 1846401 Regulation CCND1 MAPK11 17407548 1846403 Regulation CCND1 MAPK11 19159010 1055234 Regulation CCND1 MAPK11 20113529 1853277 Regulation CCND1 MAPK11 25077542 577959 Regulation CCND1 MAPK12 17205132 2374396 Regulation CCND1 MAPK12 19159010 1055235 Regulation CCND1 MAPK12 20113529 1853278 Regulation CCND1 MAPK12 25077542 577960 Regulation CCND1 MAPK13 17205132 2374397 Regulation CCND1 MAPK13 19159010 1055236 Regulation CCND1 MAPK13 20113529 1853279 Regulation CCND1 MAPK13 25077542 577961 Regulation CCND1 MAPK14 17205132 2374398 Regulation CCND1 MAPK14 19159010 1055237 Regulation CCND1 MAPK14 20113529 1853280 Regulation CCND1 MAPK14 25077542 577962 Regulation CCND1 MAPK15 17205132 2374391 Regulation CCND1 MAPK15 19159010 1055231 Regulation CCND1 MAPK15 20113529 1853271 Regulation CCND1 MAPK15 25077542 577956 Regulation CCND1 MAPK3 17205132 2374399 Regulation CCND1 MAPK3 19159010 1055238 Regulation CCND1 MAPK3 20113529 1853281 Regulation CCND1 MAPK3 22253905 2588318 Regulation CCND1 MAPK3 24004818 1618328 Regulation CCND1 MAPK3 24962785 297240 Regulation CCND1 MAPK3 25077542 577963 Regulation CCND1 MAPK4 17205132 2374400 Regulation CCND1 MAPK4 19159010 1055239 Regulation CCND1 MAPK4 20113529 1853282 Regulation CCND1 MAPK4 25077542 577964 Regulation CCND1 MAPK6 17205132 2374401 Regulation CCND1 MAPK6 19159010 1055240 Regulation CCND1 MAPK6 20113529 1853283 Regulation CCND1 MAPK6 25077542 577965 Regulation CCND1 MAPK7 17205132 2374402 Regulation CCND1 MAPK7 19159010 1055241 Regulation CCND1 MAPK7 20113529 1853284 Regulation CCND1 MAPK7 25077542 577966 Regulation CCND1 MAPK8 17205132 2374403 Regulation CCND1 MAPK8 19159010 1055242 Regulation CCND1 MAPK8 20113529 1853285 Regulation CCND1 MAPK8 25077542 577967 Regulation CCND1 MAPK9 17205132 2374404 Regulation CCND1 MAPK9 19159010 1055243 Regulation CCND1 MAPK9 20113529 1853286 Regulation CCND1 MAPK9 25077542 577968 Regulation CCND1 MIR15B 24995320 194192 Regulation CCND1 MIR17HG 22382486 1639702 Regulation CCND1 MIR20A 21765466 2141166 Regulation CCND1 MIR499A 24040263 2846296 Regulation CCND1 MIR499A 24040263 2846302 Regulation CCND1 MST1 21423209 2138733 Regulation CCND1 MSTN 22427853 2610421 Regulation CCND1 MTA1 21209952 2492569 Regulation CCND1 MTA1 21209952 2492584 Regulation CCND1 MTA2 21209952 2492570 Regulation CCND1 MTA2 21209952 2492585 Regulation CCND1 MTA3 21209952 2492568 Regulation CCND1 MTA3 21209952 2492583 Regulation CCND1 MTOR 19669214 1619250 Regulation CCND1 MTOR 22359572 2597693 Regulation CCND1 MTOR 25486097 3032731 Regulation CCND1 MUC1 24979278 2160484 Regulation CCND1 MUC1 24979278 2160485 Regulation CCND1 MUC1 24979278 2160522 Regulation CCND1 MUC1 24979278 2160525 Regulation CCND1 MUC1 24979278 2160527 Regulation CCND1 MYBL2 25279451 505297 Regulation CCND1 MYC 24349321 2897479 Regulation CCND1 MYC 24991193 484742 Regulation CCND1 MYC 24991193 484748 Regulation CCND1 MYLIP 18695042 1354631 Regulation CCND1 MYLIP 18701644 2035889 Regulation CCND1 MYLIP 18701644 2035896 Regulation CCND1 MYLIP 18701644 2035898 Regulation CCND1 MYLIP 18701644 2035902 Regulation CCND1 MYLIP 20346098 465388 Regulation CCND1 MYLIP 20868483 330154 Regulation CCND1 MYLIP 20885820 672587 Regulation CCND1 MYLIP 21240262 1961397 Regulation CCND1 MYLIP 21368870 550810 Regulation CCND1 MYLIP 21569481 1505323 Regulation CCND1 MYLIP 21765466 2141163 Regulation CCND1 MYLIP 21765466 2141164 Regulation CCND1 MYLIP 22319632 2595648 Regulation CCND1 MYLIP 22319632 2595650 Regulation CCND1 MYLIP 22319632 2595658 Regulation CCND1 MYLIP 22382486 1639701 Regulation CCND1 MYLIP 22417299 1616614 Regulation CCND1 MYLIP 22564414 1397752 Regulation CCND1 MYLIP 22564414 1397755 Regulation CCND1 MYLIP 22911796 2676635 Regulation CCND1 MYLIP 22912826 2679562 Regulation CCND1 MYLIP 22912826 2679563 Regulation CCND1 MYLIP 22912826 2679565 Regulation CCND1 MYLIP 22912826 2679567 Regulation CCND1 MYLIP 22942717 1097076 Regulation CCND1 MYLIP 22942717 1097080 Regulation CCND1 MYLIP 22942717 1097082 Regulation CCND1 MYLIP 23284982 2731411 Regulation CCND1 MYLIP 23383003 2747579 Regulation CCND1 MYLIP 23383271 2749829 Regulation CCND1 MYLIP 23383271 2749833 Regulation CCND1 MYLIP 23383271 2749845 Regulation CCND1 MYLIP 23383271 2749855 Regulation CCND1 MYLIP 23558708 3126594 Regulation CCND1 MYLIP 23558708 3126595 Regulation CCND1 MYLIP 23558708 3126596 Regulation CCND1 MYLIP 23558708 3126617 Regulation CCND1 MYLIP 23613955 2782838 Regulation CCND1 MYLIP 23880895 606254 Regulation CCND1 MYLIP 24281118 501767 Regulation CCND1 MYLIP 24495516 1701285 Regulation CCND1 MYLIP 24744457 738415 Regulation CCND1 MYLIP 24812632 190369 Regulation CCND1 MYLIP 24949940 2981986 Regulation CCND1 MYLIP 24995320 194187 Regulation CCND1 MYLIP 24995320 194189 Regulation CCND1 MYLIP 25007077 2987435 Regulation CCND1 MYLIP 25401928 3027843 Regulation CCND1 NBN 25486524 2160771 Regulation CCND1 NBPF10 22701175 1831326 Regulation CCND1 NCOA3 23511556 440354 Regulation CCND1 NDRG2 24146910 2868237 Regulation CCND1 NFATC1 23226213 2723747 Regulation CCND1 NFKB1 12633504 479928 Regulation CCND1 NFKB1 12633504 479929 Regulation CCND1 NFKB1 12633504 479939 Regulation CCND1 NGF 22509106 1914189 Regulation CCND1 NME2 22192927 834201 Regulation CCND1 NOTCH1 21743488 2140752 Regulation CCND1 NOTCH3 21743488 2140753 Regulation CCND1 NPM1 18625744 1551568 Regulation CCND1 NPY6R 24137325 2165464 Regulation CCND1 NQO2 24968355 2984294 Regulation CCND1 NQO2 24968355 2984308 Regulation CCND1 NQO2 24968355 2984348 Regulation CCND1 NR0B1 20421209 2053461 Regulation CCND1 NR0B1 23118901 2712053 Regulation CCND1 NRAS 23268747 587787 Regulation CCND1 NUMB 24980814 2194704 Regulation CCND1 OGT 23552487 2155904 Regulation CCND1 OGT 25000257 2160560 Regulation CCND1 OPN1LW 24305655 502533 Regulation CCND1 ORAI3 24058448 2847555 Regulation CCND1 PAK1 23950862 2832646 Regulation CCND1 PAK3 24163148 728811 Regulation CCND1 PCNA 10471034 415075 Regulation CCND1 PDLIM7 24499623 1507712 Regulation CCND1 PDLIM7 24499623 1507738 Regulation CCND1 PDLIM7 24499623 1507739 Regulation CCND1 PELP1 17525794 2013930 Regulation CCND1 PER2 18334030 1489040 Regulation CCND1 PER2 18334030 1489048 Regulation CCND1 PGA3 17726044 2030292 Regulation CCND1 PGA4 17726044 2030293 Regulation CCND1 PGA5 17726044 2030294 Regulation CCND1 PHIP 23118901 2712052 Regulation CCND1 PI3 16984645 279329 Regulation CCND1 PI3 23895220 269530 Regulation CCND1 PIK3CA 22829234 217932 Regulation CCND1 PIK3CA 23300886 2737112 Regulation CCND1 PIK3CA 23383143 2748421 Regulation CCND1 PIK3CA 24578720 3177510 Regulation CCND1 PIK3R1 22829234 217933 Regulation CCND1 PIK3R1 23300886 2737113 Regulation CCND1 PIK3R1 23383143 2748422 Regulation CCND1 PIK3R1 24578720 3177511 Regulation CCND1 PIN1 12631385 457634 Regulation CCND1 PIN1 20801874 1188439 Regulation CCND1 PIN1 24416409 2908513 Regulation CCND1 PIN1 25160749 1234597 Regulation CCND1 PIN1 25160749 1234601 Regulation CCND1 PINX1 24268029 1870344 Regulation CCND1 PITX2 23316168 960787 Regulation CCND1 PKM 23070542 542311 Regulation CCND1 PLN 25609920 744498 Regulation CCND1 PLN 25609920 744499 Regulation CCND1 PLN 25609920 744539 Regulation CCND1 PLN 25632222 745112 Regulation CCND1 PMPCB 23974100 544265 Regulation CCND1 PMPCB 23974100 544266 Regulation CCND1 POLDIP2 17407548 1846400 Regulation CCND1 PRDX2 16503970 1845085 Regulation CCND1 PRDX2 16503970 1845096 Regulation CCND1 PRDX2 16503970 1845099 Regulation CCND1 PRDX2 16504004 1845118 Regulation CCND1 PRDX2 16504004 1845119 Regulation CCND1 PRDX2 16504004 1845125 Regulation CCND1 PRDX2 16504004 1845126 Regulation CCND1 PRDX2 16504004 1845134 Regulation CCND1 PRDX2 16504004 1845186 Regulation CCND1 PRDX2 16504004 1845187 Regulation CCND1 PRDX2 16504004 1845203 Regulation CCND1 PRDX2 16504004 1845204 Regulation CCND1 PRDX2 17018141 1845583 Regulation CCND1 PRDX2 17407548 1846293 Regulation CCND1 PRDX2 24280698 2244886 Regulation CCND1 PRDX2 24280698 2244890 Regulation CCND1 PRDX2 24280698 2244892 Regulation CCND1 PRDX2 24970821 2194593 Regulation CCND1 PRKAA1 19046439 1646481 Regulation CCND1 PRKAA1 24505341 2920679 Regulation CCND1 PRKAA2 19046439 1646482 Regulation CCND1 PRKAA2 24505341 2920680 Regulation CCND1 PRKAB1 19046439 1646483 Regulation CCND1 PRKAB1 24505341 2920681 Regulation CCND1 PRKAB2 19046439 1646484 Regulation CCND1 PRKAB2 24505341 2920682 Regulation CCND1 PRKAG1 19046439 1646485 Regulation CCND1 PRKAG1 24505341 2920683 Regulation CCND1 PRKAG2 19046439 1646486 Regulation CCND1 PRKAG2 24505341 2920684 Regulation CCND1 PSEN1 11266469 1269218 Regulation CCND1 PSEN1 11266469 1269222 Regulation CCND1 PSME3 24281003 442576 Regulation CCND1 PTEN 11402061 1270968 Regulation CCND1 PTEN 19707334 175475 Regulation CCND1 PTEN 20926450 1033227 Regulation CCND1 PTEN 21904669 799094 Regulation CCND1 PTS 24139500 391348 Regulation CCND1 RAC1 23864022 1937160 Regulation CCND1 RAD1 25409181 3028402 Regulation CCND1 RAD1 25409181 3028403 Regulation CCND1 RAD1 25409181 3028404 Regulation CCND1 RAD1 25409181 3028405 Regulation CCND1 RAD1 25409181 3028472 Regulation CCND1 RAD1 25409181 3028500 Regulation CCND1 RAD1 25409181 3028514 Regulation CCND1 RAD1 25409181 3028528 Regulation CCND1 RAD1 25409181 3028543 Regulation CCND1 RAD1 25409181 3028564 Regulation CCND1 RAD17 25409181 3028406 Regulation CCND1 RAD17 25409181 3028407 Regulation CCND1 RAD17 25409181 3028408 Regulation CCND1 RAD17 25409181 3028409 Regulation CCND1 RAD17 25409181 3028473 Regulation CCND1 RAD17 25409181 3028501 Regulation CCND1 RAD17 25409181 3028515 Regulation CCND1 RAD17 25409181 3028529 Regulation CCND1 RAD17 25409181 3028544 Regulation CCND1 RAD17 25409181 3028565 Regulation CCND1 RAD18 25409181 3028397 Regulation CCND1 RAD18 25409181 3028398 Regulation CCND1 RAD18 25409181 3028399 Regulation CCND1 RAD18 25409181 3028400 Regulation CCND1 RAD18 25409181 3028470 Regulation CCND1 RAD18 25409181 3028499 Regulation CCND1 RAD18 25409181 3028513 Regulation CCND1 RAD18 25409181 3028527 Regulation CCND1 RAD18 25409181 3028541 Regulation CCND1 RAD18 25409181 3028563 Regulation CCND1 RAD21 25409181 3028410 Regulation CCND1 RAD21 25409181 3028411 Regulation CCND1 RAD21 25409181 3028412 Regulation CCND1 RAD21 25409181 3028413 Regulation CCND1 RAD21 25409181 3028474 Regulation CCND1 RAD21 25409181 3028502 Regulation CCND1 RAD21 25409181 3028516 Regulation CCND1 RAD21 25409181 3028530 Regulation CCND1 RAD21 25409181 3028545 Regulation CCND1 RAD21 25409181 3028566 Regulation CCND1 RAD50 25409181 3028414 Regulation CCND1 RAD50 25409181 3028415 Regulation CCND1 RAD50 25409181 3028416 Regulation CCND1 RAD50 25409181 3028417 Regulation CCND1 RAD50 25409181 3028475 Regulation CCND1 RAD50 25409181 3028503 Regulation CCND1 RAD50 25409181 3028517 Regulation CCND1 RAD50 25409181 3028531 Regulation CCND1 RAD50 25409181 3028546 Regulation CCND1 RAD50 25409181 3028567 Regulation CCND1 RAD51 25409181 3028418 Regulation CCND1 RAD51 25409181 3028419 Regulation CCND1 RAD51 25409181 3028420 Regulation CCND1 RAD51 25409181 3028421 Regulation CCND1 RAD51 25409181 3028476 Regulation CCND1 RAD51 25409181 3028504 Regulation CCND1 RAD51 25409181 3028518 Regulation CCND1 RAD51 25409181 3028532 Regulation CCND1 RAD51 25409181 3028547 Regulation CCND1 RAD51 25409181 3028568 Regulation CCND1 RAD52 25409181 3028422 Regulation CCND1 RAD52 25409181 3028423 Regulation CCND1 RAD52 25409181 3028424 Regulation CCND1 RAD52 25409181 3028425 Regulation CCND1 RAD52 25409181 3028477 Regulation CCND1 RAD52 25409181 3028505 Regulation CCND1 RAD52 25409181 3028519 Regulation CCND1 RAD52 25409181 3028533 Regulation CCND1 RAD52 25409181 3028548 Regulation CCND1 RAD52 25409181 3028569 Regulation CCND1 RALB 21714887 482254 Regulation CCND1 RANBP9 24312406 2889208 Regulation CCND1 RANBP9 24312406 2889229 Regulation CCND1 RANBP9 24312406 2889247 Regulation CCND1 RANBP9 24312406 2889251 Regulation CCND1 RASSF1 20825665 403125 Regulation CCND1 RASSF1 22438769 1243123 Regulation CCND1 RASSF1 22701175 1831327 Regulation CCND1 RB1 23383245 2749739 Regulation CCND1 RB1 7640224 444114 Regulation CCND1 RB1 8175885 1445648 Regulation CCND1 RB1 8175885 1445676 Regulation CCND1 RB1 8175885 1445677 Regulation CCND1 RB1 8175885 1445678 Regulation CCND1 RB1 8175885 1445680 Regulation CCND1 RBBP4 22639737 798277 Regulation CCND1 RBBP4 22639737 798285 Regulation CCND1 RBBP7 22639737 798278 Regulation CCND1 RBBP7 22639737 798286 Regulation CCND1 RBP2 25015565 2195820 Regulation CCND1 RELA 22541644 3161072 Regulation CCND1 REM2 23535166 151340 Regulation CCND1 RHO 16776827 3107314 Regulation CCND1 RHO 19730435 785917 Regulation CCND1 RHOA 16776827 3107317 Regulation CCND1 RNF146 24454854 2910151 Regulation CCND1 RNF146 24454854 2910183 Regulation CCND1 RNF146 24454854 2910184 Regulation CCND1 RNF146 24454854 2910191 Regulation CCND1 RNF19A 17407548 1846399 Regulation CCND1 RNF19A 17407548 1846402 Regulation CCND1 RNU12-2P 25486097 3032739 Regulation CCND1 RPL17 24886298 734636 Regulation CCND1 RPS6KA3 24416220 2907350 Regulation CCND1 SENP1 23738079 3081126 Regulation CCND1 SENP1 24970135 207833 Regulation CCND1 SETD2 23300831 2736161 Regulation CCND1 SETD4 24738023 1242068 Regulation CCND1 SHH 22799764 265247 Regulation CCND1 SHH 22799764 265274 Regulation CCND1 SIX1 23527134 2769579 Regulation CCND1 SIX1 23527134 2769584 Regulation CCND1 SIX1 23527134 2769589 Regulation CCND1 SIX1 23527134 2769592 Regulation CCND1 SKIV2L 24970170 208660 Regulation CCND1 SKP2 17205132 2374361 Regulation CCND1 SLC20A1 19808898 787727 Regulation CCND1 SLC30A9 17344318 2026679 Regulation CCND1 SLIT2 22140553 2576651 Regulation CCND1 SMAD1 24236150 2878749 Regulation CCND1 SMAD2 24236150 2878750 Regulation CCND1 SMAD3 24236150 2878751 Regulation CCND1 SMAD4 24236150 2878752 Regulation CCND1 SMAD5 24236150 2878753 Regulation CCND1 SMAD6 24236150 2878754 Regulation CCND1 SMAD7 24236150 2878755 Regulation CCND1 SMAD9 24236150 2878756 Regulation CCND1 SOAT1 22348037 2596592 Regulation CCND1 SOAT1 23300886 2737097 Regulation CCND1 SOX6 24040263 2846305 Regulation CCND1 SOX9 19725955 302684 Regulation CCND1 SP1 22911796 2676664 Regulation CCND1 SRC 22276155 2590227 Regulation CCND1 SRC 22276155 2590231 Regulation CCND1 SRC 22276155 2590233 Regulation CCND1 SRC 22927910 2680929 Regulation CCND1 SRC 22927910 2680930 Regulation CCND1 SRC 22927910 2680961 Regulation CCND1 SRC 22927910 2681011 Regulation CCND1 SRC 22927910 2681041 Regulation CCND1 SRC 24137325 2165459 Regulation CCND1 SRC 24137325 2165460 Regulation CCND1 SRC 24137325 2165463 Regulation CCND1 SRF 23426188 2163702 Regulation CCND1 SRF 23426188 2163703 Regulation CCND1 STAT3 22216901 1698091 Regulation CCND1 STAT3 22216901 1698101 Regulation CCND1 STAT3 22348037 2596585 Regulation CCND1 STAT3 22348037 2596593 Regulation CCND1 STAT3 22833568 1806163 Regulation CCND1 STAT3 22833568 1806168 Regulation CCND1 STAT3 22973518 1079313 Regulation CCND1 STAT3 23874455 2821375 Regulation CCND1 STAT3 24069553 1706827 Regulation CCND1 STAT3 24199193 184789 Regulation CCND1 STAT3 24499623 1507711 Regulation CCND1 STAT3 24499623 1507736 Regulation CCND1 STAT3 24499623 1507737 Regulation CCND1 STAT3 24743778 504408 Regulation CCND1 STAT3 24743778 504409 Regulation CCND1 STAT3 25143751 645502 Regulation CCND1 STAT3 25295272 200783 Regulation CCND1 STAT3 25337545 1241248 Regulation CCND1 STAT5A 19242540 2406310 Regulation CCND1 STAT5A 19242540 2406363 Regulation CCND1 STAT5A 19630967 464602 Regulation CCND1 STAT5A 22276155 2590215 Regulation CCND1 STAT5A 22276155 2590221 Regulation CCND1 STAT5A 22276155 2590224 Regulation CCND1 STAT5A 22919439 2224664 Regulation CCND1 STAT5A 22927910 2680931 Regulation CCND1 STAT5A 22927910 2680954 Regulation CCND1 STAT5A 22927910 2680968 Regulation CCND1 STAT5A 22927910 2681012 Regulation CCND1 STAT5A 24913037 273789 Regulation CCND1 STAT5B 19630967 464603 Regulation CCND1 STAT5B 22485142 2616773 Regulation CCND1 STC2 23187001 219777 Regulation CCND1 STC2 23187001 219778 Regulation CCND1 STS 24739942 2953657 Regulation CCND1 SUMO1 18025037 2031779 Regulation CCND1 SUV39H1 19906718 2048296 Regulation CCND1 SUV39H1 19906718 2048297 Regulation CCND1 SYT1 22541644 3161071 Regulation CCND1 SYT1 22835384 624970 Regulation CCND1 SYT1 25412312 579216 Regulation CCND1 TAB2 21151996 2485697 Regulation CCND1 TBL1XR1 25341494 475991 Regulation CCND1 TCF12 16990252 2022799 Regulation CCND1 TCF12 19479035 2417396 Regulation CCND1 TCF12 21209952 2492598 Regulation CCND1 TCF12 22651859 1648824 Regulation CCND1 TCF15 16990252 2022800 Regulation CCND1 TCF15 19479035 2417397 Regulation CCND1 TCF15 21209952 2492599 Regulation CCND1 TCF15 22651859 1648825 Regulation CCND1 TCF19 16990252 2022801 Regulation CCND1 TCF19 19479035 2417398 Regulation CCND1 TCF19 21209952 2492600 Regulation CCND1 TCF19 22651859 1648826 Regulation CCND1 TCF20 16990252 2022802 Regulation CCND1 TCF20 19479035 2417399 Regulation CCND1 TCF20 21209952 2492601 Regulation CCND1 TCF20 22651859 1648827 Regulation CCND1 TCF21 16990252 2022803 Regulation CCND1 TCF21 19479035 2417400 Regulation CCND1 TCF21 21209952 2492602 Regulation CCND1 TCF21 22651859 1648828 Regulation CCND1 TCF23 16990252 2022807 Regulation CCND1 TCF23 19479035 2417404 Regulation CCND1 TCF23 21209952 2492606 Regulation CCND1 TCF23 22651859 1648832 Regulation CCND1 TCF24 16990252 2022809 Regulation CCND1 TCF24 19479035 2417406 Regulation CCND1 TCF24 21209952 2492608 Regulation CCND1 TCF24 22651859 1648834 Regulation CCND1 TCF25 16990252 2022808 Regulation CCND1 TCF25 19479035 2417405 Regulation CCND1 TCF25 21209952 2492607 Regulation CCND1 TCF25 22651859 1648833 Regulation CCND1 TCF3 16990252 2022804 Regulation CCND1 TCF3 19479035 2417401 Regulation CCND1 TCF3 21209952 2492603 Regulation CCND1 TCF3 22651859 1648829 Regulation CCND1 TCF4 16990252 2022805 Regulation CCND1 TCF4 19479035 2417402 Regulation CCND1 TCF4 21209952 2492604 Regulation CCND1 TCF4 22651859 1648830 Regulation CCND1 TCF7 16990252 2022806 Regulation CCND1 TCF7 19479035 2417403 Regulation CCND1 TCF7 21209952 2492605 Regulation CCND1 TCF7 22651859 1648831 Regulation CCND1 TCF7L1 24832538 2970650 Regulation CCND1 TCF7L2 20548773 2452674 Regulation CCND1 TJP2 24665396 3178929 Regulation CCND1 TMED7 21151996 2485698 Regulation CCND1 TNC 25138052 2198195 Regulation CCND1 TNFSF11 21345282 467146 Regulation CCND1 TNFSF13 19291294 252552 Regulation CCND1 TOB1 22158108 14213 Regulation CCND1 TP53 21197417 549240 Regulation CCND1 TP53 22539978 2622736 Regulation CCND1 TP53 23164821 1901014 Regulation CCND1 TRAF6 21151996 2485695 Regulation CCND1 TRIB2 24708856 1873764 Regulation CCND1 TSC22D3 19814803 1852094 Regulation CCND1 TTC37 24970170 208661 Regulation CCND1 UBE2D3 23741361 2800493 Regulation CCND1 UBE2V1 21151996 2485696 Regulation CCND1 VANGL2 23579212 440526 Regulation CCND1 VHL 15026807 424408 Regulation CCND1 VHL 19602254 253749 Regulation CCND1 WDR61 24970170 208662 Regulation CCND1 WNT1 20565980 465634 Regulation CCND1 WNT1 20802536 2135952 Regulation CCND1 WNT1 21629692 2525529 Regulation CCND1 WNT1 23772418 945469 Regulation CCND1 WNT1 24755523 2189369 Regulation CCND1 WNT11 20802536 2135953 Regulation CCND1 WNT11 21629692 2525530 Regulation CCND1 WNT11 23772418 945470 Regulation CCND1 WNT11 24755523 2189370 Regulation CCND1 WNT16 20802536 2135958 Regulation CCND1 WNT16 21629692 2525535 Regulation CCND1 WNT16 23772418 945475 Regulation CCND1 WNT16 24755523 2189375 Regulation CCND1 WNT2 20802536 2135954 Regulation CCND1 WNT2 21629692 2525531 Regulation CCND1 WNT2 23772418 945471 Regulation CCND1 WNT2 24755523 2189371 Regulation CCND1 WNT3 20802536 2135955 Regulation CCND1 WNT3 21629692 2525532 Regulation CCND1 WNT3 23772418 945472 Regulation CCND1 WNT3 24755523 2189372 Regulation CCND1 WNT4 20802536 2135956 Regulation CCND1 WNT4 21629692 2525533 Regulation CCND1 WNT4 23772418 945473 Regulation CCND1 WNT4 24755523 2189373 Regulation CCND1 WNT6 20802536 2135957 Regulation CCND1 WNT6 21629692 2525534 Regulation CCND1 WNT6 23772418 945474 Regulation CCND1 WNT6 24755523 2189374 Regulation CCND1 XPO1 16504004 1845117 Regulation CCND1 XPO1 16504004 1845198 Regulation CCND1 XPO1 17224055 580983 Regulation CCND1 YBX1 23462806 440321 Regulation CCND1 YBX3 24885929 379002 Regulation CCND1 ZBTB4 21765466 2141165 Regulation CCND2 HBEGF 22646534 264702 Regulation CCND2 TLR7 18180309 1548219 Regulation CCNF IFI27 22158041 2144799 Regulation CCNG1 CCND1 23552696 2156339 Regulation CCNG1 CDKN1C 22216119 2584403 Regulation CCNG1 CTGF 24152728 1819397 Regulation CCNG1 CTGF 24152728 1819404 Regulation CCNG1 CTGF 24152728 1819406 Regulation CCNG1 IFI27 20200561 1719463 Regulation CCNG1 NMNAT2 23610559 2283007 Regulation CCNG2 FOXO1 25488803 476408 Regulation CCNT1 RNASE1 24985203 3124789 Regulation CCNT1 RNASE7 24985203 3124797 Regulation CCNT2 RNASE1 24985203 3124801 Regulation CCNT2 RNASE7 24985203 3124809 Regulation CCP110 IFI27 22158041 2144800 Regulation CCR2 FOXO1 22586579 722754 Regulation CCR2 FOXO1 22586579 722763 Regulation CCR2 FOXO1 22586579 722776 Regulation CCR2 FOXO1 22586579 722778 Regulation CCR2 TLR7 24466057 2912738 Regulation CCR2 TNF 24384839 1122809 Regulation CCR4 CCL17 19715610 3109784 Regulation CCR4 CCL17 24339934 2894326 Regulation CCR4 TNF 10562323 1513186 Regulation CCR5 TLR7 23028330 3059500 Regulation CCR5 TNF 21508508 736872 Regulation CCR6 TLR7 23554682 1225975 Regulation CCR7 FOXO1 22654881 901225 Regulation CCR7 FOXO1 23183047 1570130 Regulation CCR7 TLR7 18461564 807333 Regulation CCR7 TNF 21468000 1905577 Regulation CCR7 TNF 22951718 1631200 Regulation CD14 AKT1 20011115 3045847 Regulation CD14 AKT2 20011115 3045848 Regulation CD14 AKT3 20011115 3045849 Regulation CD14 CD4 23131784 1919441 Regulation CD14 CD4 23131784 1919442 Regulation CD14 CD4 23131784 1919443 Regulation CD14 CD4 23131784 1919477 Regulation CD14 CSF1 24651442 573467 Regulation CD14 CSF2 11686890 3103533 Regulation CD14 CSK 24349012 2896573 Regulation CD14 DUT 22566960 900543 Regulation CD14 HMOX1 24651442 573469 Regulation CD14 IFNG 8163930 1594280 Regulation CD14 IL22 23131784 1919438 Regulation CD14 IL22 23131784 1919439 Regulation CD14 IL22 23131784 1919440 Regulation CD14 IL22 23131784 1919476 Regulation CD14 IL33 23236253 983743 Regulation CD14 IL4 11686890 3103534 Regulation CD14 KLF13 23236253 983742 Regulation CD14 LTA 24349012 2896574 Regulation CD14 NELFCD 15975149 3105079 Regulation CD14 PAM 24349012 2896575 Regulation CD14 PI3 10587349 1513474 Regulation CD14 ST2 23429360 838598 Regulation CD14 TLR4 23408095 863985 Regulation CD14 TLR4 25421042 1887455 Regulation CD14 TNF 14960189 656439 Regulation CD14 TNF 14960189 656440 Regulation CD14 TNF 21700881 719544 Regulation CD151 ARSA 23292489 1886164 Regulation CD177 ANGPT1 22152684 124451 Regulation CD19 CD22 19707370 175626 Regulation CD1B ID1 24572994 1142520 Regulation CD209 EPHB2 18282094 3040990 Regulation CD22 LYN 9547345 1602693 Regulation CD22 PTPN6 8627166 1596134 Regulation CD24 PLAU 23864708 1817026 Regulation CD24 S100A7 23300877 2736923 Regulation CD248 TNF 24555435 271766 Regulation CD27 TNF 19007423 111966 Regulation CD274 EPHB2 23737812 637511 Regulation CD274 EPHB2 24945934 2981802 Regulation CD274 MAP2K6 23737812 637518 Regulation CD274 TNF 19451266 1554824 Regulation CD274 TNF 22067141 1660213 Regulation CD274 TNF 22389764 3130459 Regulation CD274 TNF 23882269 908248 Regulation CD276 TLR7 22815909 2666723 Regulation CD28 ITGAL 1569401 1534410 Regulation CD28 ITGAL 16159396 3105655 Regulation CD28 TNF 16277694 104766 Regulation CD33 TNF 22500980 355796 Regulation CD34 TNFSF10 24823879 1126638 Regulation CD36 PGC 21904680 154552 Regulation CD36 PGC 22272266 2589502 Regulation CD36 RCAN1 24127415 783283 Regulation CD36 SCARA3 23799536 1936938 Regulation CD36 TNF 17335569 108119 Regulation CD36 TNF 21029292 590590 Regulation CD36 TNF 23840095 1753422 Regulation CD36 TNF 23914732 230406 Regulation CD36 TNFSF10 24466325 2914331 Regulation CD38 TNF 18341691 3108825 Regulation CD38 TNF 18341691 3108826 Regulation CD38 TNF 18341691 3108842 Regulation CD38 TNF 18341691 3108859 Regulation CD4 CD14 23131784 1919444 Regulation CD4 CD14 23131784 1919445 Regulation CD4 CD14 23131784 1919478 Regulation CD4 FAS 12177809 422000 Regulation CD4 FAS 16636134 1540120 Regulation CD4 FAS 19424421 3043792 Regulation CD4 FAS 21573156 2522700 Regulation CD4 ITGAL 25414732 641078 Regulation CD4 JAG1 11581320 1521132 Regulation CD4 JAG1 20633267 119716 Regulation CD4 JAG1 20633267 119717 Regulation CD4 JAG1 20953370 1672669 Regulation CD4 JAG1 23060881 904605 Regulation CD4 JAG1 23060881 904606 Regulation CD4 MIP 7595201 1590758 Regulation CD4 MUC16 24204874 2874496 Regulation CD4 MUC16 24204874 2874706 Regulation CD4 MUC16 24455435 3151217 Regulation CD4 NT5E 25242869 1762306 Regulation CD4 PECAM1 8691148 1598507 Regulation CD4 TLR7 17283209 1544275 Regulation CD4 TLR7 21251257 354300 Regulation CD4 TLR7 21251257 354320 Regulation CD4 TLR7 21998589 3053959 Regulation CD4 TLR7 23028330 3059510 Regulation CD4 TNF 16277694 104767 Regulation CD4 TNF 18477401 1640964 Regulation CD4 TNF 21085470 2370885 Regulation CD4 TNF 21423609 2508120 Regulation CD4 TNF 21556142 2517740 Regulation CD4 TNF 21556142 2517752 Regulation CD4 TNF 21556142 2517767 Regulation CD4 TNF 22003408 2562351 Regulation CD4 TNF 23300801 2736008 Regulation CD4 TNF 23300801 2736018 Regulation CD4 TNF 23300801 2736019 Regulation CD4 TNF 23300801 2736026 Regulation CD4 TNF 23493728 1624164 Regulation CD4 TNF 23774102 1492612 Regulation CD4 TNF 25490675 3033298 Regulation CD40 CHI3L1 7693850 1591603 Regulation CD40 EPHB2 25255446 2372973 Regulation CD40LG EPHB2 22537317 355816 Regulation CD40LG TNF 21282461 1385181 Regulation CD44 ID1 24572994 1142521 Regulation CD46 CCND1 25009466 869652 Regulation CD47 TNF PMC2750202 450203 Regulation CD55 FOXO1 21909281 2326137 Regulation CD55 FOXO1 23300463 2340956 Regulation CD55 FOXO1 23786484 33013 Regulation CD63 F2R 20177584 1046997 Regulation CD69 EPHB2 23758320 151544 Regulation CD69 EPHB2 PMC2833665 134285 Regulation CD69 ITGAL 16159396 3105657 Regulation CD74 FAS 25304249 1510818 Regulation CD79A CD22 10209047 1511615 Regulation CD79A CD22 19447770 3126149 Regulation CD79A CD22 20098688 2437862 Regulation CD79A CD22 20098688 2437869 Regulation CD79A CD22 20098688 2437880 Regulation CD79A CD22 22545114 2623414 Regulation CD79A CD22 22566885 899457 Regulation CD79A CD22 PMC3991031 2245474 Regulation CD79A FOXO1 18978794 1951902 Regulation CD79A JAG1 21980444 2560520 Regulation CD79A PECAM1 23233201 1141354 Regulation CD79A PECAM1 23233201 1141371 Regulation CD79A PIGR 10859341 1515961 Regulation CD79A TGM2 22451718 1567889 Regulation CD79A TGM2 22606433 515106 Regulation CD79A TLR7 23690823 637330 Regulation CD79A TNF 23774102 1492615 Regulation CD79B CD22 10209047 1511616 Regulation CD79B CD22 19447770 3126151 Regulation CD79B CD22 20098688 2437863 Regulation CD79B CD22 20098688 2437870 Regulation CD79B CD22 20098688 2437881 Regulation CD79B CD22 22545114 2623415 Regulation CD79B CD22 22566885 899470 Regulation CD79B CD22 PMC3991031 2245476 Regulation CD79B FOXO1 18978794 1951903 Regulation CD79B PECAM1 23233201 1141355 Regulation CD79B PECAM1 23233201 1141372 Regulation CD80 TLR7 18509450 2389678 Regulation CD80 TLR7 21587207 769705 Regulation CD81 TNF 24259385 1029579 Regulation CD83 TNF 25111504 2996285 Regulation CD86 CHI3L1 7595208 1590807 Regulation CD86 CHI3L1 7595208 1590808 Regulation CD86 TLR7 21912648 2552514 Regulation CD86 TLR7 24586760 2926330 Regulation CD8A FAS 12177809 422001 Regulation CD8A FAS 16636134 1540128 Regulation CD8A JAG1 20953370 1672670 Regulation CD8A NT5E 25242869 1762308 Regulation CD8A TCN1 17394654 1620484 Regulation CD8A TLR7 21998589 3053954 Regulation CD8A TLR7 22723955 2655394 Regulation CD8A TNF 10637268 1514137 Regulation CD8A TNF 17183635 2373593 Regulation CD8A TNF 22003411 2562378 Regulation CD8A TNF 23383283 2750087 Regulation CD8A TNF 23658704 2789804 Regulation CD8A TNF 23774102 1492620 Regulation CD8A TNF 23874808 2822896 Regulation CD8A TNF 7869050 1592797 Regulation CD8B TLR7 21998589 3053955 Regulation CD8B TNF 10637268 1514138 Regulation CD8B TNF 22003411 2562380 Regulation CD8B TNF 23383283 2750088 Regulation CD8B TNF 23774102 1492623 Regulation CD8B TNF 7869050 1592798 Regulation CD9 TSPAN1 25200404 3145433 Regulation CDC123 SLC6A2 22383977 2602634 Regulation CDC16 SLC6A2 22383977 2602635 Regulation CDC20 SLC6A2 22383977 2602636 Regulation CDC20 STK39 24025726 364083 Regulation CDC23 SLC6A2 22383977 2602637 Regulation CDC25C EPHB2 24023871 2843867 Regulation CDC26 SLC6A2 22383977 2602646 Regulation CDC27 SLC6A2 22383977 2602638 Regulation CDC34 SLC6A2 22383977 2602639 Regulation CDC37 SLC6A2 22383977 2602640 Regulation CDC40 SLC6A2 22383977 2602641 Regulation CDC42 CTGF 23902294 344721 Regulation CDC42 EPHB2 19182796 1965180 Regulation CDC42 PLAU 12952933 1296542 Regulation CDC42 SLC6A2 22383977 2602642 Regulation CDC45 SLC6A2 22383977 2602643 Regulation CDC6 SLC6A2 22383977 2602644 Regulation CDC7 SLC6A2 22383977 2602645 Regulation CDC73 ARSA 18475637 1745103 Regulation CDC73 CCND1 19906718 2048312 Regulation CDC73 LPCAT1 25415055 177554 Regulation CDC73 SLC6A2 22383977 2602633 Regulation CDC73 TNF 3119758 1580153 Regulation CDC73 TNF 3119758 1580154 Regulation CDC73 TNF 3119758 1580178 Regulation CDCA5 NES 21278733 1966556 Regulation CDCA5 TNF 21736731 1898348 Regulation CDH1 ARSA 23146664 154194 Regulation CDH1 ARSA 24184502 154212 Regulation CDH1 ARSA 24184502 154233 Regulation CDH1 CLU 22949882 1098130 Regulation CDH1 EPHB2 14623871 1301400 Regulation CDH1 EPHB2 14623871 1301401 Regulation CDH1 EPHB2 14623871 1301473 Regulation CDH1 EPHB2 14623871 1301474 Regulation CDH1 EPHB2 14623871 1301475 Regulation CDH1 EPHB2 14623871 1301478 Regulation CDH1 EPHB2 16278666 426800 Regulation CDH1 EPHB2 24130883 2867475 Regulation CDH1 EPHB2 24168056 1700777 Regulation CDH1 ETV7 23029494 2698469 Regulation CDH1 ETV7 23029494 2698470 Regulation CDH1 FOXQ1 23383267 2749812 Regulation CDH1 ID1 24137437 2165750 Regulation CDH1 IFI27 9679152 1469029 Regulation CDH1 IFI27 9679152 1469031 Regulation CDH1 JAG1 24391948 2905012 Regulation CDH1 JAG1 25144746 3001219 Regulation CDH1 MAP2K6 23208503 2150305 Regulation CDH1 MAP2K6 23208503 2150592 Regulation CDH1 MMP28 22312325 696850 Regulation CDH1 MMP7 22312325 696865 Regulation CDH1 MMP7 23054081 93214 Regulation CDH1 MMP7 23173031 2719402 Regulation CDH1 NEDD9 21765937 2536530 Regulation CDH1 NEDD9 21765937 2536531 Regulation CDH1 NEDD9 21765937 2536543 Regulation CDH1 NEDD9 24058594 2848133 Regulation CDH1 NEDD9 24058594 2848154 Regulation CDH1 TSPAN1 14691142 1303271 Regulation CDH1 TSPAN1 14691142 1303783 Regulation CDH1 UNC5B 19492039 2417970 Regulation CDH1 VSNL1 22479362 2614939 Regulation CDH10 MAP2K6 23208503 2150602 Regulation CDH10 TSPAN1 14691142 1303293 Regulation CDH10 TSPAN1 14691142 1303805 Regulation CDH10 UNC5B 19492039 2417971 Regulation CDH11 MAP2K6 23208503 2150612 Regulation CDH11 TSPAN1 14691142 1303315 Regulation CDH11 TSPAN1 14691142 1303827 Regulation CDH11 UNC5B 19492039 2417972 Regulation CDH12 MAP2K6 23208503 2150622 Regulation CDH12 TSPAN1 14691142 1303337 Regulation CDH12 TSPAN1 14691142 1303849 Regulation CDH12 UNC5B 19492039 2417973 Regulation CDH13 MAP2K6 23208503 2150632 Regulation CDH13 TSPAN1 14691142 1303359 Regulation CDH13 TSPAN1 14691142 1303871 Regulation CDH13 UNC5B 19492039 2417974 Regulation CDH15 MAP2K6 23208503 2150642 Regulation CDH15 TSPAN1 14691142 1303381 Regulation CDH15 TSPAN1 14691142 1303893 Regulation CDH15 UNC5B 19492039 2417975 Regulation CDH16 MAP2K6 23208503 2150652 Regulation CDH16 TSPAN1 14691142 1303403 Regulation CDH16 TSPAN1 14691142 1303915 Regulation CDH16 UNC5B 19492039 2417976 Regulation CDH17 MAP2K6 23208503 2150662 Regulation CDH17 TSPAN1 14691142 1303425 Regulation CDH17 TSPAN1 14691142 1303937 Regulation CDH17 UNC5B 19492039 2417977 Regulation CDH18 MAP2K6 23208503 2150672 Regulation CDH18 TSPAN1 14691142 1303447 Regulation CDH18 TSPAN1 14691142 1303959 Regulation CDH18 UNC5B 19492039 2417978 Regulation CDH19 MAP2K6 23208503 2150682 Regulation CDH19 TSPAN1 14691142 1303469 Regulation CDH19 TSPAN1 14691142 1303981 Regulation CDH19 UNC5B 19492039 2417979 Regulation CDH2 EPHB2 20011526 2433439 Regulation CDH2 MAP2K6 23208503 2150312 Regulation CDH2 MAP2K6 23208503 2150692 Regulation CDH2 MMP28 20139113 513545 Regulation CDH2 MMP7 20139113 513560 Regulation CDH2 MMP7 24400123 2905909 Regulation CDH2 TSPAN1 14691142 1303491 Regulation CDH2 TSPAN1 14691142 1304003 Regulation CDH2 UNC5B 19492039 2417980 Regulation CDH20 MAP2K6 23208503 2150702 Regulation CDH20 TSPAN1 14691142 1303513 Regulation CDH20 TSPAN1 14691142 1304025 Regulation CDH20 UNC5B 19492039 2417981 Regulation CDH22 MAP2K6 23208503 2150552 Regulation CDH22 TSPAN1 14691142 1303183 Regulation CDH22 TSPAN1 14691142 1303695 Regulation CDH22 UNC5B 19492039 2417966 Regulation CDH23 MAP2K6 23208503 2150562 Regulation CDH23 TSPAN1 14691142 1303205 Regulation CDH23 TSPAN1 14691142 1303717 Regulation CDH23 UNC5B 19492039 2417967 Regulation CDH24 MAP2K6 23208503 2150572 Regulation CDH24 TSPAN1 14691142 1303227 Regulation CDH24 TSPAN1 14691142 1303739 Regulation CDH24 UNC5B 19492039 2417968 Regulation CDH26 MAP2K6 23208503 2150582 Regulation CDH26 TSPAN1 14691142 1303249 Regulation CDH26 TSPAN1 14691142 1303761 Regulation CDH26 UNC5B 19492039 2417969 Regulation CDH3 MAP2K6 23208503 2150712 Regulation CDH3 TSPAN1 14691142 1303535 Regulation CDH3 TSPAN1 14691142 1304047 Regulation CDH3 UNC5B 19492039 2417982 Regulation CDH4 MAP2K6 23208503 2150722 Regulation CDH4 TSPAN1 14691142 1303557 Regulation CDH4 TSPAN1 14691142 1304069 Regulation CDH4 UNC5B 19492039 2417983 Regulation CDH5 ANGPT1 23253477 1401593 Regulation CDH5 CHI3L1 23665676 2152224 Regulation CDH5 EPHB2 23157718 3207799 Regulation CDH5 MAP2K6 23208503 2150732 Regulation CDH5 MMP28 20139113 513607 Regulation CDH5 MMP7 20139113 513622 Regulation CDH5 PODXL 25520612 939438 Regulation CDH5 TNF 24992685 2986595 Regulation CDH5 TSPAN1 14691142 1303579 Regulation CDH5 TSPAN1 14691142 1304091 Regulation CDH5 UNC5B 19492039 2417984 Regulation CDH6 ID1 24069422 2853344 Regulation CDH6 MAP2K6 23208503 2150742 Regulation CDH6 TSPAN1 14691142 1303601 Regulation CDH6 TSPAN1 14691142 1304113 Regulation CDH6 UNC5B 19492039 2417985 Regulation CDH7 MAP2K6 23208503 2150752 Regulation CDH7 TSPAN1 14691142 1303623 Regulation CDH7 TSPAN1 14691142 1304135 Regulation CDH7 UNC5B 19492039 2417986 Regulation CDH8 MAP2K6 23208503 2150762 Regulation CDH8 TSPAN1 14691142 1303645 Regulation CDH8 TSPAN1 14691142 1304157 Regulation CDH8 UNC5B 19492039 2417987 Regulation CDH9 MAP2K6 23208503 2150772 Regulation CDH9 TSPAN1 14691142 1303667 Regulation CDH9 TSPAN1 14691142 1304179 Regulation CDH9 UNC5B 19492039 2417988 Regulation CDHR3 MAP3K11 24811194 1768831 Regulation CDK1 CCND1 18700973 463085 Regulation CDK1 ID1 16966095 792744 Regulation CDK1 ID1 24572994 1142523 Regulation CDK1 STK39 23349762 2743073 Regulation CDK10 CCND1 18700973 463087 Regulation CDK10 ID1 16966095 792746 Regulation CDK12 CCND1 18700973 463098 Regulation CDK12 ID1 16966095 792757 Regulation CDK13 CCND1 18700973 463086 Regulation CDK13 ID1 16966095 792745 Regulation CDK14 CCND1 18700973 463105 Regulation CDK14 ID1 16966095 792761 Regulation CDK15 CCND1 18700973 463084 Regulation CDK15 ID1 16966095 792743 Regulation CDK16 CCND1 18700973 463102 Regulation CDK16 ID1 16966095 792758 Regulation CDK17 CCND1 18700973 463103 Regulation CDK17 ID1 16966095 792759 Regulation CDK18 CCND1 18700973 463104 Regulation CDK18 ID1 16966095 792760 Regulation CDK19 CCND1 18700973 463096 Regulation CDK19 EPHB2 23209347 1750873 Regulation CDK19 ID1 16966095 792755 Regulation CDK19 RCAN1 19124655 1553442 Regulation CDK19 TF PMC3611773 1616048 Regulation CDK19 TLR7 18584038 3073276 Regulation CDK19 TLR7 18584038 3073987 Regulation CDK19 TNF 23824685 2809220 Regulation CDK19 TNF 25275456 2373060 Regulation CDK19 TNF 3435705 443440 Regulation CDK2 CCND1 18700973 463088 Regulation CDK2 CCND1 21720559 2531784 Regulation CDK2 CCND1 23469073 2761198 Regulation CDK2 CCND1 23866847 1700159 Regulation CDK2 CCND1 24157878 568580 Regulation CDK2 CCND1 9026502 1459173 Regulation CDK2 FAS 10075979 1511242 Regulation CDK2 FOXO1 21931533 2277076 Regulation CDK2 ID1 16966095 792747 Regulation CDK2 IFI27 17088910 428326 Regulation CDK2 IFI27 23055977 959151 Regulation CDK2 IFI27 23394599 267828 Regulation CDK2 IFI27 24392268 686193 Regulation CDK20 CCND1 18700973 463097 Regulation CDK20 ID1 16966095 792756 Regulation CDK3 CCND1 18700973 463089 Regulation CDK3 ID1 16966095 792748 Regulation CDK4 CCND1 18700973 463090 Regulation CDK4 CCND1 22754369 1096174 Regulation CDK4 CCND1 22754369 1096187 Regulation CDK4 CCND1 23028659 2692332 Regulation CDK4 CCND1 24074866 517548 Regulation CDK4 CCND1 25344914 2206042 Regulation CDK4 FAS 23237220 625275 Regulation CDK4 ID1 16966095 792749 Regulation CDK4 TLR7 21559334 2518371 Regulation CDK5 ARSA 17274829 1238115 Regulation CDK5 CAPN8 19830249 1213148 Regulation CDK5 CCND1 18700973 463091 Regulation CDK5 EPHB2 24498195 2918904 Regulation CDK5 ID1 16966095 792750 Regulation CDK5 IFI27 23294285 987916 Regulation CDK5 NES 21278733 1966524 Regulation CDK5 NES 21278733 1966537 Regulation CDK5 NES 21278733 1966557 Regulation CDK5 NES 21346193 1788641 Regulation CDK5 NES 21902831 3160714 Regulation CDK5R1 CCND1 22833568 1806127 Regulation CDK5R1 EPHB2 22833568 1806164 Regulation CDK6 CCND1 18700973 463092 Regulation CDK6 CCND1 23028659 2692333 Regulation CDK6 CCND1 25344914 2206043 Regulation CDK6 ID1 16966095 792751 Regulation CDK7 CCND1 18700973 463093 Regulation CDK7 ID1 16966095 792752 Regulation CDK8 CCND1 18700973 463094 Regulation CDK8 EPHB2 22319481 860877 Regulation CDK8 EPHB2 23209347 1750871 Regulation CDK8 EPHB2 24065881 931220 Regulation CDK8 ID1 16966095 792753 Regulation CDK8 MAP2K6 24065881 931226 Regulation CDK8 RCAN1 19124655 1553440 Regulation CDK8 TF PMC3611773 1616046 Regulation CDK8 TLR7 18584038 3073256 Regulation CDK8 TLR7 18584038 3073967 Regulation CDK8 TNF 23824685 2809218 Regulation CDK8 TNF 25275456 2373058 Regulation CDK8 TNF 3435705 443438 Regulation CDK9 CCND1 18700973 463095 Regulation CDK9 EDN2 18195069 1548453 Regulation CDK9 ID1 16966095 792754 Regulation CDK9 PGC 18575576 2391594 Regulation CDK9 RNASE1 24985203 3124813 Regulation CDK9 RNASE7 24985203 3124821 Regulation CDKN1A CCND1 22860097 2671588 Regulation CDKN1A CCND1 23620761 2783318 Regulation CDKN1A CCND1 23638178 2787820 Regulation CDKN1A EPHB2 10491389 1249404 Regulation CDKN1A EPHB2 10491389 1249405 Regulation CDKN1A EPHB2 10491389 1249414 Regulation CDKN1A EPHB2 10491389 1249428 Regulation CDKN1A EPHB2 16351709 1845018 Regulation CDKN1A EPHB2 20855497 1560271 Regulation CDKN1A EPHB2 20855497 1560276 Regulation CDKN1A EPHB2 22312430 2595207 Regulation CDKN1A EPHB2 23029062 2694448 Regulation CDKN1A EPHB2 23573093 1069210 Regulation CDKN1A EPHB2 25196936 1730906 Regulation CDKN1A FOXO1 22123859 1394158 Regulation CDKN1A FOXO1 24436017 494508 Regulation CDKN1A FOXO1 24886245 1874792 Regulation CDKN1A FOXO1 25488803 476432 Regulation CDKN1A ID1 18092003 2381433 Regulation CDKN1A ID1 20842131 435935 Regulation CDKN1A ID1 20842131 435948 Regulation CDKN1A ID1 22139302 1879333 Regulation CDKN1A ID1 22139302 1879372 Regulation CDKN1A ID1 22139302 1879420 Regulation CDKN1A ID1 22139302 1879462 Regulation CDKN1A ID1 23342268 491926 Regulation CDKN1A ID1 23342268 491929 Regulation CDKN1A ID1 23342268 491931 Regulation CDKN1A ID1 23342268 491936 Regulation CDKN1A ID1 23342268 491941 Regulation CDKN1A IFI27 19025580 1503411 Regulation CDKN1A IFI27 19267931 3109324 Regulation CDKN1A MAP2K6 16351709 1845024 Regulation CDKN1A MAP2K6 22531632 438617 Regulation CDKN1A MAP2K6 24820097 2968885 Regulation CDKN1A TNF 17565690 1846531 Regulation CDKN1A TNF 17565690 1846532 Regulation CDKN1A TNF 23193206 729954 Regulation CDKN1B CCND1 23620761 2783320 Regulation CDKN1B EPHB2 23029062 2694449 Regulation CDKN1B FOXO1 21418583 259355 Regulation CDKN1B FOXO1 21418583 259356 Regulation CDKN1B FOXO1 21418583 259357 Regulation CDKN1B FOXO1 22123859 1394162 Regulation CDKN1B ID1 20842131 435937 Regulation CDKN1B ID1 20842131 435950 Regulation CDKN1B IFI27 23342268 491927 Regulation CDKN1B TNF 17565690 1846535 Regulation CDKN1C AKT1 23470457 543070 Regulation CDKN1C AKT2 23470457 543071 Regulation CDKN1C AKT3 23470457 543072 Regulation CDKN1C BCL11A 23000964 1928618 Regulation CDKN1C BCL11B 22588081 771827 Regulation CDKN1C BMF 24475314 2915500 Regulation CDKN1C COPS2 23287466 542607 Regulation CDKN1C COPS3 23287466 542604 Regulation CDKN1C COPS4 23287466 542602 Regulation CDKN1C COPS5 23287466 542605 Regulation CDKN1C COPS6 23287466 542603 Regulation CDKN1C COPS8 23287466 542606 Regulation CDKN1C CXCR4 18378795 1550250 Regulation CDKN1C DNMT1 24886104 3114611 Regulation CDKN1C EED 22386265 691497 Regulation CDKN1C EGR1 23087602 937489 Regulation CDKN1C EZH2 19340297 2411492 Regulation CDKN1C EZH2 19340297 2411493 Regulation CDKN1C EZH2 22386265 691498 Regulation CDKN1C H19 17786216 2378013 Regulation CDKN1C HDAC1 22386265 691499 Regulation CDKN1C HDAC1 24886104 3114612 Regulation CDKN1C HDAC2 22386265 691500 Regulation CDKN1C HDAC2 24886104 3114613 Regulation CDKN1C IGF2 19924280 2431517 Regulation CDKN1C KCNQ1OT1 15888726 2016391 Regulation CDKN1C KCNQ1OT1 20673338 243805 Regulation CDKN1C KCNQ1OT1 23751783 799787 Regulation CDKN1C MIR221 21278784 12425 Regulation CDKN1C MYLIP 21278784 12422 Regulation CDKN1C MYLIP 21278784 12423 Regulation CDKN1C MYLIP 21278784 12424 Regulation CDKN1C MYLIP 21278784 12429 Regulation CDKN1C MYLIP 21278784 12435 Regulation CDKN1C MYLIP 21278784 12436 Regulation CDKN1C MYLIP 21278784 12437 Regulation CDKN1C MYLIP 24308935 1158398 Regulation CDKN1C NAP1L1 25071868 803809 Regulation CDKN1C NAP1L2 24413569 3139327 Regulation CDKN1C NR4A2 23087602 937490 Regulation CDKN1C PRC1 22386265 691501 Regulation CDKN1C RBBP4 22386265 691502 Regulation CDKN1C RBBP4 24886104 3114614 Regulation CDKN1C RBBP7 22386265 691503 Regulation CDKN1C RBBP7 24886104 3114615 Regulation CDKN1C SMARCA4 20596014 1985506 Regulation CDKN1C SMARCB1 19221586 2405771 Regulation CDKN1C SMARCB1 19221586 2405778 Regulation CDKN1C SMARCB1 19221586 2405779 Regulation CDKN1C SMARCB1 19221586 2405795 Regulation CDKN1C SOD2 24308935 1158397 Regulation CDKN1C SUZ12 22386265 691496 Regulation CDKN1C TP53 21042410 2479609 Regulation CDKN1C YY1 22386265 691495 Regulation CDKN2A CCND1 24212955 499351 Regulation CDKN2A EPHB2 21836819 648269 Regulation CDKN2A EPHB2 23853661 821301 Regulation CDKN2A ID1 18320031 2384860 Regulation CDKN2A IFI27 PMC2360767 448449 Regulation CDKN2A MAP2K6 21836819 648275 Regulation CDKN2A TNF 21738489 2325075 Regulation CDKN2B DAPK1 24216985 500736 Regulation CDL1 ITGB2 1717478 1335489 Regulation CEACAM6 CSE 23941132 3113921 Regulation CEACAM6 EDN1 18472935 1743247 Regulation CEACAM6 HNF1A 18028549 1848406 Regulation CEACAM6 IL8 12589085 1634148 Regulation CEACAM6 MTDH 24586388 2924441 Regulation CEACAM6 SLC22A3 25398131 3027601 Regulation CEACAM6 TRIM27 18336069 2264311 Regulation CEACAM6 UNC80 18336069 2264308 Regulation CEACAM6 UNC80 18336069 2264309 Regulation CEACAM6 UNC80 18336069 2264310 Regulation CEACAM6 UNC80 18336069 2264321 Regulation CEBPA TNF 10098766 414110 Regulation CEBPA TNF 10098766 414112 Regulation CEBPB TNF 21283687 2497293 Regulation CEBPD TNF 23525087 1958643 Regulation CEBPZ EDN2 20388225 1891592 Regulation CEP104 MMP28 16157686 1537288 Regulation CEP104 MMP7 16157686 1537303 Regulation CEP112 MMP28 16157686 1537552 Regulation CEP112 MMP7 16157686 1537567 Regulation CEP120 MMP28 16157686 1537508 Regulation CEP120 MMP7 16157686 1537523 Regulation CEP128 MMP28 16157686 1537244 Regulation CEP128 MMP7 16157686 1537259 Regulation CEP135 MMP28 16157686 1537640 Regulation CEP135 MMP7 16157686 1537655 Regulation CEP152 MMP28 16157686 1537684 Regulation CEP152 MMP7 16157686 1537699 Regulation CEP164 MMP28 16157686 1537662 Regulation CEP164 MMP7 16157686 1537677 Regulation CEP170 MMP28 16157686 1537574 Regulation CEP170 MMP7 16157686 1537589 Regulation CEP19 MMP28 16157686 1537530 Regulation CEP19 MMP7 16157686 1537545 Regulation CEP192 MMP28 16157686 1537354 Regulation CEP192 MMP7 16157686 1537369 Regulation CEP250 MMP28 16157686 1537222 Regulation CEP250 MMP7 16157686 1537237 Regulation CEP290 MMP28 16157686 1537596 Regulation CEP290 MMP7 16157686 1537611 Regulation CEP350 MMP28 16157686 1537266 Regulation CEP350 MMP7 16157686 1537281 Regulation CEP41 MMP28 16157686 1537200 Regulation CEP41 MMP7 16157686 1537215 Regulation CEP44 MMP28 16157686 1537706 Regulation CEP44 MMP7 16157686 1537721 Regulation CEP55 MMP28 16157686 1537178 Regulation CEP55 MMP7 16157686 1537193 Regulation CEP57 MMP28 16157686 1537750 Regulation CEP57 MMP7 16157686 1537765 Regulation CEP63 MMP28 16157686 1537442 Regulation CEP63 MMP7 16157686 1537457 Regulation CEP68 MMP28 16157686 1537618 Regulation CEP68 MMP7 16157686 1537633 Regulation CEP70 MMP28 16157686 1537728 Regulation CEP70 MMP7 16157686 1537743 Regulation CEP72 MMP28 16157686 1537376 Regulation CEP72 MMP7 16157686 1537391 Regulation CEP76 MMP28 16157686 1537398 Regulation CEP76 MMP7 16157686 1537413 Regulation CEP78 MMP28 16157686 1537420 Regulation CEP78 MMP7 16157686 1537435 Regulation CEP85 MMP28 16157686 1537332 Regulation CEP85 MMP7 16157686 1537347 Regulation CEP89 MMP28 16157686 1537464 Regulation CEP89 MMP7 16157686 1537479 Regulation CEP95 MMP28 16157686 1537310 Regulation CEP95 MMP7 16157686 1537325 Regulation CEP97 MMP28 16157686 1537486 Regulation CEP97 MMP7 16157686 1537501 Regulation CERKL RNASE1 24498393 2919591 Regulation CERS1 ELOVL4 23826266 2811858 Regulation CERS2 ELOVL4 23826266 2811855 Regulation CERS3 ELOVL4 23826266 2811868 Regulation CERS4 ELOVL4 23826266 2811862 Regulation CERS5 ELOVL4 23826266 2811865 Regulation CERS6 ELOVL4 23826266 2811871 Regulation CFI ADIPOQ 21779180 2325548 Regulation CFI CDK2 21690308 1389387 Regulation CFI NPY6R 21779180 2325549 Regulation CFL1 ABCA12 25237832 2200393 Regulation CFL1 MAP2K6 24117811 1043144 Regulation CFL2 ABCA12 25237832 2200397 Regulation CFL2 MAP2K6 24117811 1043154 Regulation CFLAR EPHB2 25019384 2988871 Regulation CFLAR MUC16 24690311 272537 Regulation CFLAR TNF 15138489 424518 Regulation CFLAR TNFSF10 24690311 272604 Regulation CFTR ANO1 24885604 359396 Regulation CFTR ANO1 24885604 359401 Regulation CFTR CAPN8 23785472 2806319 Regulation CFTR CAPN8 23785472 2806361 Regulation CFTR FAS 15869703 2112233 Regulation CFTR TNF 19847291 2429242 Regulation CGA FOXO1 25423188 3030056 Regulation CGB8 FOXO1 25423188 3030055 Regulation CH25H TLR7 24069554 1706885 Regulation CHAT TNF 23840379 2812661 Regulation CHDH FOXA1 25343614 3019639 Regulation CHDH PRODH 24039956 2845122 Regulation CHEK2 TNFSF10 21092294 1860278 Regulation CHGA RNASE1 25101113 896648 Regulation CHGA RNASE7 25101113 896656 Regulation CHI3L1 AVP 19662198 178053 Regulation CHI3L1 GORASP1 23226395 2724435 Regulation CHI3L1 IL1B 23409001 2753150 Regulation CHI3L1 MIR449A 23226395 2724443 Regulation CHI3L1 MYLIP 25358394 1946491 Regulation CHI3L1 RELB 23451236 2758422 Regulation CHI3L1 STAT6 24416647 1708204 Regulation CHI3L1 VEGFA 23755018 961420 Regulation CHI3L1 VEGFA 23755018 961424 Regulation CHI3L1 VEGFA 24878721 2975423 Regulation CHI3L1 VEGFA 24878721 2975425 Regulation CHI3L1 VEGFA 24878721 2975426 Regulation CHI3L2 IL1B 23409001 2753151 Regulation CHKA EPHB2 21772273 1933154 Regulation CHKA EPHB2 21772273 1933172 Regulation CHM JAG1 24587363 2929714 Regulation CHM JAG1 24587363 2929724 Regulation CHRDL1 ASCL1 24360028 1998869 Regulation CHRDL1 BMP2 19771160 2426917 Regulation CHRDL1 BMP2 19771160 2426921 Regulation CHRDL1 HES5 24360028 1998868 Regulation CHRDL1 NHLH1 24360028 1998870 Regulation CHRFAM7A TCN1 8920864 1599467 Regulation CHUK IFI27 25099287 3144969 Regulation CHUK TLR7 22984582 2689196 Regulation CHUK TLR7 24527057 825297 Regulation CHUK TNF 10359587 1511924 Regulation CHUK TNF 10359587 1511948 Regulation CHUK TNF 11238593 1519032 Regulation CHUK TNF 17925009 233621 Regulation CHUK TNF 20087353 434414 Regulation CHUK TNF 20351780 2444605 Regulation CHUK TNF 21119000 1783951 Regulation CHUK TNF 21119000 1783976 Regulation CHUK TNF 22768286 2660431 Regulation CHUK TNF 23104095 1958299 Regulation CHUK TNF 24386331 2903504 Regulation CHUK TNF 24386331 2903542 Regulation CHUK TNF 24487321 1959863 Regulation CIB1 CCND1 24143227 2867937 Regulation CIB1 EPHB2 23029062 2694447 Regulation CIB1 EPHB2 24426773 1916663 Regulation CIB1 FOXO1 24741631 1621410 Regulation CISH CD14 20011115 3045901 Regulation CISH CD14 20011115 3045945 Regulation CISH CD14 21387014 2506193 Regulation CISH UCA1 24069250 2852287 Regulation CKAP4 FOXO1 23906066 700780 Regulation CKAP4 TP63 22247000 777630 Regulation CLDN10 EGF 23685873 1106962 Regulation CLDN10 EGF 23685873 1106987 Regulation CLDN10 ESRRG 22511979 2619182 Regulation CLDN10 F11R 22371556 1395819 Regulation CLDN10 MARVELD3 20028514 283829 Regulation CLDN10 MYLIP 22511979 2619164 Regulation CLDN10 MYLIP 22511979 2619165 Regulation CLDN10 MYLIP 22511979 2619166 Regulation CLDN10 MYLIP 22511979 2619175 Regulation CLDN10 MYLIP 22511979 2619178 Regulation CLDN10 MYLIP 22511979 2619181 Regulation CLDN10 OCLN 23924897 1817668 Regulation CLDN10 OXA1L 22511979 2619167 Regulation CLDN5 TNF 24992685 2986597 Regulation CLEC2D TLR7 24352438 1704392 Regulation CLEC2D TLR7 24352438 1704412 Regulation CLEC2D TLR7 24352438 1704435 Regulation CLIP3 TNF 22297296 554131 Regulation CLN3 FOXO1 21541341 2516988 Regulation CLTCL1 TNF 24204966 2874984 Regulation CLTCL1 TNF 24204966 2874985 Regulation CLU CA2 22384125 2605997 Regulation CLU CALML3 24097188 1963616 Regulation CLU CDH1 22949882 1098132 Regulation CLU CR1 22989354 1665053 Regulation CLU EGR1 24156019 492153 Regulation CLU HSF1 24156019 492154 Regulation CLU HSPA5 23457489 2758653 Regulation CLU HSPA5 25392688 490146 Regulation CLU HSPB1 25138053 2198206 Regulation CLU ID1 16677418 459814 Regulation CLU KLK3 24156019 492149 Regulation CLU MYBL2 PMC2750202 450213 Regulation CLU MYC 20639536 2056224 Regulation CLU MYCN 23362253 1206181 Regulation CLU MYCN 23362253 1206185 Regulation CLU NOTCH1 25452709 939387 Regulation CLU NOTCH2 25452709 939388 Regulation CLU NOTCH3 25452709 939389 Regulation CLU NOTCH4 25452709 939390 Regulation CLU SETD2 24599003 1883357 Regulation CLU SLC12A2 21284844 1996611 Regulation CLU SLC12A2 24949446 192679 Regulation CLU SLC12A2 25206759 2005885 Regulation CLU SLC12A2 25354791 1946489 Regulation CLU SLC12A5 22065950 865860 Regulation CLU SLC12A5 23596389 930885 Regulation CLU SLC12A5 24567703 868739 Regulation CLU TLR4 24979331 1483702 Regulation CLU VHL 24599003 1883356 Regulation CLU WNT1 17634137 1645568 Regulation CLU WNT1 17634137 1645593 Regulation CLU WNT11 17634137 1645569 Regulation CLU WNT11 17634137 1645594 Regulation CLU WNT16 17634137 1645574 Regulation CLU WNT16 17634137 1645599 Regulation CLU WNT2 17634137 1645570 Regulation CLU WNT2 17634137 1645595 Regulation CLU WNT3 17634137 1645571 Regulation CLU WNT3 17634137 1645596 Regulation CLU WNT4 17634137 1645572 Regulation CLU WNT4 17634137 1645597 Regulation CLU WNT6 17634137 1645573 Regulation CLU WNT6 17634137 1645598 Regulation CMIP TNF 23238132 651905 Regulation CMKLR1 TNF 25049696 136351 Regulation CMKLR1 TNF 25049696 136352 Regulation CMKLR1 TNF 25049696 136357 Regulation CNGB1 MMP28 22699690 621538 Regulation CNGB1 MMP7 22699690 621553 Regulation CNN1 MAP2K6 10330402 1246079 Regulation CNN2 MAP2K6 10330402 1246081 Regulation CNN3 MAP2K6 10330402 1246083 Regulation CNR1 MAP2K6 22362764 1201317 Regulation CNR2 EPHB2 24312195 2888271 Regulation COA1 ACSS1 24278309 2885760 Regulation COA1 FAS 24217114 501191 Regulation COA3 ACSS1 24278309 2885762 Regulation COA3 FAS 24217114 501195 Regulation COA4 ACSS1 24278309 2885761 Regulation COA4 FAS 24217114 501193 Regulation COA5 ACSS1 24278309 2885763 Regulation COA5 FAS 24217114 501197 Regulation COA6 ACSS1 24278309 2885759 Regulation COA6 FAS 24217114 501189 Regulation COG2 PCSK9 25426564 658122 Regulation COG2 PCSK9 25426564 658124 Regulation COG2 PCSK9 25470376 2119146 Regulation COIL LAMB3 8647901 1451706 Regulation COL17A1 AIRE 23781320 787392 Regulation COL17A1 HDAC1 9660880 1468397 Regulation COL17A1 PLEC 9660880 1468398 Regulation COL17A1 SOX9 22761195 2180397 Regulation COL1A1 CTGF 22329991 1567422 Regulation COL1A1 CTGF 23663495 128405 Regulation COL1A1 CTGF 24090133 537564 Regulation COL1A1 CTGF 24090133 537615 Regulation COL1A1 EPHB2 22942680 1096785 Regulation COL1A1 EPHB2 24011378 3114103 Regulation COL1A1 EPHB2 24090133 537616 Regulation COL1A1 EPHB2 24090133 537651 Regulation COL1A1 EPHB2 24090133 537683 Regulation COL1A1 MAP2K6 24011378 3114109 Regulation COL1A1 MAP2K6 24090133 537622 Regulation COL1A1 MAP2K6 24090133 537657 Regulation COL1A1 MAP2K6 24090133 537689 Regulation COL1A1 TLR7 25610471 3174557 Regulation COL1A2 CTGF 23663495 128406 Regulation COL1A2 CTGF 24090133 537566 Regulation COL1A2 CTGF 24090133 537624 Regulation COL1A2 EPHB2 22942680 1096786 Regulation COL1A2 EPHB2 24011378 3114111 Regulation COL1A2 EPHB2 24090133 537625 Regulation COL1A2 EPHB2 24090133 537659 Regulation COL1A2 EPHB2 24090133 537691 Regulation COL1A2 MAP2K6 24011378 3114117 Regulation COL1A2 MAP2K6 24090133 537631 Regulation COL1A2 MAP2K6 24090133 537665 Regulation COL1A2 MAP2K6 24090133 537697 Regulation COL1A2 MMP7 24273653 2251308 Regulation COL1A2 MMP7 24273653 2251310 Regulation COL1A2 TLR7 25610471 3174567 Regulation COL1A2 TNF 11549373 98467 Regulation COL2A1 TNF 15642133 102100 Regulation COL2A1 TNF 19435506 113282 Regulation COMP ADAMTS1 22906101 126660 Regulation COMT MAOA 24966828 898434 Regulation COMT TNF 22866165 1239687 Regulation CORD1 TLR7 17485512 1545810 Regulation CORD1 TNF 17485512 1545809 Regulation CORO6 SPHK1 19390594 2415360 Regulation CORO7 SPHK1 19390594 2415363 Regulation CPE FOXO1 19767734 1960799 Regulation CPE FOXO1 19767734 1960803 Regulation CPLX1 PGC 25610371 872918 Regulation CPLX1 PGC 25610371 872927 Regulation CPOX IL1B 10815617 1737062 Regulation CPOX PGC 20661474 2456768 Regulation CPOX PGC 23226091 2244449 Regulation CPSF3L EPHB2 22131969 860780 Regulation CPT1A FOXO1 22533991 264539 Regulation CPT1A FOXO1 22533991 264540 Regulation CPT1A FOXO1 23469153 2762494 Regulation CPT1A PGC 21915347 2553455 Regulation CPT1A PGC 23355796 1061212 Regulation CPT2 PGC 23093952 3076037 Regulation CR1 CLU 22989354 1665054 Regulation CREB1 ALOX5 22222029 1894622 Regulation CREB1 EPHB2 12969508 382315 Regulation CREB1 EPHB2 18487450 706032 Regulation CREB1 EPHB2 19684611 8024 Regulation CREB1 EPHB2 21151573 2485191 Regulation CREB1 EPHB2 21151573 2485196 Regulation CREB1 EPHB2 21441990 936217 Regulation CREB1 EPHB2 21912749 2002297 Regulation CREB1 EPHB2 22140566 2576779 Regulation CREB1 EPHB2 22817771 471869 Regulation CREB1 PTGER2 25327961 216595 Regulation CREB1 RASD1 21915321 2553247 Regulation CREB1 TNF 24386331 2903633 Regulation CREB3 ALOX5 22222029 1894623 Regulation CREB3 EPHB2 12969508 382316 Regulation CREB3 EPHB2 18487450 706046 Regulation CREB3 EPHB2 19684611 8025 Regulation CREB3 EPHB2 21151573 2485192 Regulation CREB3 EPHB2 21441990 936218 Regulation CREB3 EPHB2 21912749 2002311 Regulation CREB3 EPHB2 22140566 2576793 Regulation CREB3 PTGER2 25327961 216596 Regulation CREB3 RASD1 21915321 2553248 Regulation CREB3 TNF 24386331 2903634 Regulation CREB3L2 SOX6 24711445 1209131 Regulation CREB3L2 SOX9 24711445 1209110 Regulation CREB3L2 SOX9 24711445 1209130 Regulation CREB3L2 SOX9 24711445 1209133 Regulation CREB3L2 SOX9 24711445 1209138 Regulation CREB5 ALOX5 22222029 1894621 Regulation CREB5 EPHB2 12969508 382314 Regulation CREB5 EPHB2 18487450 706018 Regulation CREB5 EPHB2 19684611 8023 Regulation CREB5 EPHB2 21151573 2485190 Regulation CREB5 EPHB2 21441990 936216 Regulation CREB5 EPHB2 21912749 2002283 Regulation CREB5 EPHB2 22140566 2576765 Regulation CREB5 PTGER2 25327961 216594 Regulation CREB5 RASD1 21915321 2553246 Regulation CREB5 TNF 24386331 2903632 Regulation CREBBP EPHB2 21572418 1925875 Regulation CREBBP EPHB2 21860657 813154 Regulation CRIP1 TNF 22297296 554130 Regulation CRK ANGPT1 24308939 1158722 Regulation CRK CD14 20011115 3045853 Regulation CRK CD14 20011115 3045940 Regulation CRK EPHB2 18648505 2393279 Regulation CRK EPHB2 19497102 1503762 Regulation CRK EPHB2 20644716 2455976 Regulation CRK EPHB2 23638878 1868108 Regulation CRK ID1 18489764 352170 Regulation CRK MAP2K6 22415879 722050 Regulation CRK MAP2K6 22454693 814036 Regulation CRK RCAN1 19124655 1553387 Regulation CRK SPHK1 20498849 2451193 Regulation CRK TLR7 18461564 807377 Regulation CRK TNF 23079107 409267 Regulation CRK TNF 23536830 2773087 Regulation CROT FOXA1 22238690 2587079 Regulation CRP IL1B 24009648 2214726 Regulation CRP TNF 18787704 2396370 Regulation CRP TNF 19533192 3163512 Regulation CRP TNF 22216303 2585489 Regulation CRS EPHB2 22048896 3170175 Regulation CRTC1 FHL1 22174183 991803 Regulation CRYGEP ZFP57 23569325 1571509 Regulation CSDE1 LAMB3 22160594 1798631 Regulation CSDE1 RAB31 18060067 2381194 Regulation CSE SRGN 23945069 1481408 Regulation CSF1 ABCG2 25295160 3208145 Regulation CSF1 EPHB2 19144181 112532 Regulation CSF1 LINC00284 25431574 919592 Regulation CSF1 LINC00341 25431574 919552 Regulation CSF1 MAP2K6 19144181 112538 Regulation CSF1 MAP2K6 22873932 532987 Regulation CSF1 TNF 12745546 1738353 Regulation CSF1 TNF 18472951 1743309 Regulation CSF1 TNF 23762085 637605 Regulation CSF1 TNF 8605095 445331 Regulation CSF1 TNF 8605095 445332 Regulation CSF2 CA12 24391755 2904423 Regulation CSF2 EPHB2 21682898 123013 Regulation CSF2 HBEGF 20946648 1859855 Regulation CSF2 IL1B 11132773 1737254 Regulation CSF2 IL1B 11132773 1737255 Regulation CSF2 IL1B 11132773 1737256 Regulation CSF2 TLR7 24155889 2871058 Regulation CSF2 TNF 11132773 1737251 Regulation CSF2 TNF 11132773 1737252 Regulation CSF2 TNF 11132773 1737253 Regulation CSF2 TNF 1375270 1528762 Regulation CSF2 TNF 1375270 1528777 Regulation CSF2 TNF 18472951 1743310 Regulation CSF2 TNF 21861862 123877 Regulation CSF2 TNF 24564340 357491 Regulation CSF2 TNF 2647480 795350 Regulation CSF2 TNF 7500047 1588527 Regulation CSF2 TNF 7530764 1590007 Regulation CSF2 TNF 8676080 1597973 Regulation CSF2 TNF 9864375 1473485 Regulation CSF3 TNF 1373292 423500 Regulation CSF3 TNF 2647480 795352 Regulation CSF3 TNF 7530764 1590008 Regulation CSK CD14 24349012 2896576 Regulation CSN2 CTGF 20497571 285123 Regulation CSN2 PLAT 1512297 1308338 Regulation CSN3 CTGF 20497571 285122 Regulation CSN3 PLAT 1512297 1308337 Regulation CSPG4 ID1 18519801 706206 Regulation CSPG4 PLAT 25184365 3004822 Regulation CSPG5 ID1 18519801 706207 Regulation CSPG5 PLAT 25184365 3004824 Regulation CSRP1 TNF 22216303 2585484 Regulation CSRP1 TNF 25247574 1130839 Regulation CST6 CTSL 20879045 3231928 Regulation CST6 LGMN 20879045 3231929 Regulation CST6 LGMN 23088560 266735 Regulation CST6 PRDX2 19503093 2125532 Regulation CST6 SCT 22323296 1800345 Regulation CST6 SMAD3 21949838 2556830 Regulation CST6 XRCC1 20154727 2129021 Regulation CTBP1 EPHB2 21224849 769123 Regulation CTBP1 EPHB2 21224849 769132 Regulation CTBP1 EPHB2 24918976 620150 Regulation CTBP1 MAP2K6 21224849 769138 Regulation CTD PGC 18575576 2391597 Regulation CTDP1 STK39 22303389 881837 Regulation CTGF ACE2 24067190 1700565 Regulation CTGF AMOT 21224387 1190315 Regulation CTGF AMOT 21224387 1190337 Regulation CTGF AMOTL1 21224387 1190316 Regulation CTGF AMOTL1 21224387 1190338 Regulation CTGF ARID1B 22978413 292456 Regulation CTGF BMP1 21673687 436945 Regulation CTGF BMP10 21673687 436953 Regulation CTGF BMP15 21673687 436946 Regulation CTGF BMP2 21673687 436947 Regulation CTGF BMP3 21673687 436948 Regulation CTGF BMP4 15466481 1312499 Regulation CTGF BMP4 21673687 436949 Regulation CTGF BMP5 21673687 436950 Regulation CTGF BMP6 21673687 436951 Regulation CTGF BMP7 21673687 436952 Regulation CTGF CAV1 25328554 2220235 Regulation CTGF CHRFAM7A 23826206 2811435 Regulation CTGF CNR1 20068137 712489 Regulation CTGF CREBBP 22978413 292457 Regulation CTGF CXCL12 25121739 2997336 Regulation CTGF DCN 19152120 1478360 Regulation CTGF DCN 19152120 1478470 Regulation CTGF DCN 24877152 192110 Regulation CTGF DST 22552965 794957 Regulation CTGF ECM1 22802911 2219379 Regulation CTGF ECM2 22802911 2219380 Regulation CTGF EDN1 17767742 109027 Regulation CTGF EDN1 17767742 109044 Regulation CTGF EDN1 17767742 109057 Regulation CTGF EDN1 22212430 14248 Regulation CTGF EDN1 24015303 2842629 Regulation CTGF EGR1 23304166 3173804 Regulation CTGF EPHB2 17474984 656549 Regulation CTGF EPHB2 17474984 656550 Regulation CTGF EPHB2 17474984 656551 Regulation CTGF EPHB2 24090133 537594 Regulation CTGF EPHB2 25121739 2997355 Regulation CTGF ETS1 16469114 104922 Regulation CTGF ETS1 16469114 104923 Regulation CTGF ETS1 22539964 2622638 Regulation CTGF ETS1 22539964 2622642 Regulation CTGF F2R 22212430 14237 Regulation CTGF F2R 22212430 14244 Regulation CTGF F2R 22212430 14249 Regulation CTGF F2RL3 22212430 14245 Regulation CTGF FASLG 22135505 3128255 Regulation CTGF FLI1 16469114 104924 Regulation CTGF FLI1 17767743 109059 Regulation CTGF FLI1 23041765 1086779 Regulation CTGF FLI1 23663495 128408 Regulation CTGF FOXO1 19390991 1478572 Regulation CTGF GABPA 23050040 2225063 Regulation CTGF GPER1 23947803 473704 Regulation CTGF GPER1 23947803 473705 Regulation CTGF HBEGF 22330337 1717964 Regulation CTGF HBEGF 22330337 1717973 Regulation CTGF HDAC1 23281659 856442 Regulation CTGF HDAC2 23281659 856443 Regulation CTGF HRAS 24090133 537595 Regulation CTGF IGF1 22646479 336522 Regulation CTGF IGF2 22646479 336523 Regulation CTGF INS 22511849 1914257 Regulation CTGF JUN 20697347 2133467 Regulation CTGF JUN 22212430 14238 Regulation CTGF JUN 22212430 14239 Regulation CTGF JUN 22212430 14242 Regulation CTGF JUN 22212430 14243 Regulation CTGF JUN 22212430 14250 Regulation CTGF JUN 25121739 2997332 Regulation CTGF KLF15 23646205 2788761 Regulation CTGF KRAS 24090133 537596 Regulation CTGF LPA 19152120 1478361 Regulation CTGF LPA 19156540 1478485 Regulation CTGF LRP1 19152120 1478362 Regulation CTGF MAP2K1 24090133 537599 Regulation CTGF MAP2K2 24090133 537600 Regulation CTGF MAP2K3 24090133 537601 Regulation CTGF MAP2K4 24090133 537602 Regulation CTGF MAP2K5 24090133 537603 Regulation CTGF MAP2K6 24090133 537604 Regulation CTGF MAP2K7 24090133 537605 Regulation CTGF MAPK1 15608389 1634427 Regulation CTGF MAPK1 21481241 332655 Regulation CTGF MAPK1 22363806 2602000 Regulation CTGF MAPK10 15608389 1634428 Regulation CTGF MAPK10 21481241 332656 Regulation CTGF MAPK10 22363806 2602001 Regulation CTGF MAPK11 15608389 1634429 Regulation CTGF MAPK11 21481241 332657 Regulation CTGF MAPK11 22363806 2602002 Regulation CTGF MAPK12 15608389 1634430 Regulation CTGF MAPK12 21481241 332658 Regulation CTGF MAPK12 22363806 2602003 Regulation CTGF MAPK13 15608389 1634431 Regulation CTGF MAPK13 21481241 332659 Regulation CTGF MAPK13 22363806 2602004 Regulation CTGF MAPK14 15608389 1634432 Regulation CTGF MAPK14 21481241 332660 Regulation CTGF MAPK14 22363806 2602005 Regulation CTGF MAPK15 15608389 1634426 Regulation CTGF MAPK15 21481241 332654 Regulation CTGF MAPK15 22363806 2601999 Regulation CTGF MAPK3 15608389 1634433 Regulation CTGF MAPK3 21481241 332661 Regulation CTGF MAPK3 22363806 2602006 Regulation CTGF MAPK3 22938209 533080 Regulation CTGF MAPK3 23383241 2749629 Regulation CTGF MAPK3 24090133 537568 Regulation CTGF MAPK4 15608389 1634434 Regulation CTGF MAPK4 21481241 332662 Regulation CTGF MAPK4 22363806 2602007 Regulation CTGF MAPK6 15608389 1634435 Regulation CTGF MAPK6 21481241 332663 Regulation CTGF MAPK6 22363806 2602008 Regulation CTGF MAPK7 15608389 1634436 Regulation CTGF MAPK7 21481241 332664 Regulation CTGF MAPK7 22363806 2602009 Regulation CTGF MAPK8 15608389 1634437 Regulation CTGF MAPK8 21481241 332665 Regulation CTGF MAPK8 22363806 2602010 Regulation CTGF MAPK9 15608389 1634438 Regulation CTGF MAPK9 21481241 332666 Regulation CTGF MAPK9 22363806 2602011 Regulation CTGF MARCH8 25031653 1613711 Regulation CTGF MIR18A 21501375 32642 Regulation CTGF MMP3 19152120 1478363 Regulation CTGF MMP3 19152120 1478471 Regulation CTGF MRXS5 22328559 1035577 Regulation CTGF MRXS5 22328559 1035578 Regulation CTGF MUC1 20697347 2133468 Regulation CTGF MYLIP 20062521 2312598 Regulation CTGF MYLIP 21501375 32639 Regulation CTGF MYLIP 21501375 32640 Regulation CTGF MYLIP 21501375 32641 Regulation CTGF MYLIP 21501375 32648 Regulation CTGF MYLIP 21501375 32649 Regulation CTGF MYLIP 21501375 32656 Regulation CTGF MYLIP 21501375 32657 Regulation CTGF MYLIP 21501375 32668 Regulation CTGF MYLIP 21501375 32670 Regulation CTGF MYLIP 22319597 2595571 Regulation CTGF MYLIP 23533592 2770764 Regulation CTGF MYLIP 25087998 19370 Regulation CTGF MYLIP 25087998 19372 Regulation CTGF NCOA3 22978413 292461 Regulation CTGF NOV 24722330 2951155 Regulation CTGF NR3C2 15608389 1634439 Regulation CTGF NR3C2 15608389 1634456 Regulation CTGF NR3C2 15608389 1634457 Regulation CTGF NRAS 24090133 537606 Regulation CTGF NTRK1 20195389 1478630 Regulation CTGF NTRK1 20195389 1478631 Regulation CTGF NTRK1 20195389 1478632 Regulation CTGF NTRK1 20195389 1478633 Regulation CTGF NTRK1 20195389 1478635 Regulation CTGF PDGFB 20697347 2133481 Regulation CTGF POLDIP2 25144187 3000488 Regulation CTGF POLDIP2 25144187 3000490 Regulation CTGF PPARA 18274641 1741525 Regulation CTGF PPARA 25132338 19399 Regulation CTGF PPARA 25132338 19421 Regulation CTGF PROK1 21098624 1035550 Regulation CTGF PROK1 21098624 1035551 Regulation CTGF PROK1 21098624 1035552 Regulation CTGF PROK1 21098624 1035553 Regulation CTGF PROK1 21098624 1035554 Regulation CTGF PROK1 21098624 1035557 Regulation CTGF PROK1 21098624 1035558 Regulation CTGF PROK1 21098624 1035559 Regulation CTGF PROK1 21098624 1035563 Regulation CTGF PROK1 21098624 1035564 Regulation CTGF PROK1 21098624 1035565 Regulation CTGF PROK1 21098624 1035566 Regulation CTGF PROK1 21098624 1035568 Regulation CTGF PTGER2 20205862 397091 Regulation CTGF PTGER4 20205862 397092 Regulation CTGF RAC1 20205862 397079 Regulation CTGF RAC1 23856044 128774 Regulation CTGF RAC1 23856044 128820 Regulation CTGF RAC1 25121739 2997356 Regulation CTGF RBBP4 23281659 856444 Regulation CTGF RBBP7 23281659 856445 Regulation CTGF RHO 22938209 533077 Regulation CTGF RHO 24678903 856905 Regulation CTGF RHOA 19152120 1478479 Regulation CTGF ROCK1 24678903 856906 Regulation CTGF ROCK2 24678903 856907 Regulation CTGF RUNX2 22966907 1866739 Regulation CTGF SERPINA3 20299474 713241 Regulation CTGF SERPINA3 20299474 713242 Regulation CTGF SERPINA3 20299474 713243 Regulation CTGF SERPINA3 20299474 713244 Regulation CTGF SERPINA3 20299474 713245 Regulation CTGF SERPINA3 20299474 713246 Regulation CTGF SERPINA3 20299474 713247 Regulation CTGF SERPINA3 20299474 713248 Regulation CTGF SERPINA3 20299474 713249 Regulation CTGF SERPINA3 20299474 713259 Regulation CTGF SETD2 21304949 2501838 Regulation CTGF SETD2 21673687 436930 Regulation CTGF SETD2 22162692 1144839 Regulation CTGF SETD2 23947803 473702 Regulation CTGF SETD2 23947803 473703 Regulation CTGF SHOX 24887312 2975872 Regulation CTGF SHOX 24887312 2975877 Regulation CTGF SHOX 24887312 2975878 Regulation CTGF SIL1 17042939 319215 Regulation CTGF SMAD1 24090133 537675 Regulation CTGF SMAD2 21152444 2486997 Regulation CTGF SMAD2 21626291 616658 Regulation CTGF SMAD2 22978413 292458 Regulation CTGF SMAD2 24090133 537676 Regulation CTGF SMAD2 25132338 19410 Regulation CTGF SMAD2 25132338 19438 Regulation CTGF SMAD3 16469114 104927 Regulation CTGF SMAD3 22329991 1567425 Regulation CTGF SMAD3 22802915 2219599 Regulation CTGF SMAD3 22966907 1866740 Regulation CTGF SMAD3 22978413 292459 Regulation CTGF SMAD3 24090133 537677 Regulation CTGF SMAD3 25132338 19411 Regulation CTGF SMAD3 25132338 19439 Regulation CTGF SMAD4 22978413 292460 Regulation CTGF SMAD4 24090133 537678 Regulation CTGF SMAD5 24090133 537679 Regulation CTGF SMAD6 24090133 537680 Regulation CTGF SMAD7 24090133 537597 Regulation CTGF SMAD7 24090133 537598 Regulation CTGF SMAD7 24090133 537681 Regulation CTGF SMAD9 24090133 537682 Regulation CTGF SMARCA4 22978413 292452 Regulation CTGF SMARCC1 22978413 292453 Regulation CTGF SMARCC2 22978413 292454 Regulation CTGF SOX9 22072985 2327384 Regulation CTGF SPARC 20359365 118626 Regulation CTGF SRF 22563064 739554 Regulation CTGF SRF 22563064 739555 Regulation CTGF SRF 22563064 739557 Regulation CTGF STAT3 24631771 1642739 Regulation CTGF TAZ 25354978 1887238 Regulation CTGF TAZ 25354978 1887246 Regulation CTGF TEAD4 22329991 1567424 Regulation CTGF TET1 20497571 285151 Regulation CTGF TET2 20497571 285149 Regulation CTGF TET3 20497571 285150 Regulation CTGF TGFB1 17333105 732695 Regulation CTGF TGFB1 19152120 1478359 Regulation CTGF TGFB1 19152120 1478469 Regulation CTGF TGFB1 19156540 1478484 Regulation CTGF THBS1 21453480 855670 Regulation CTGF TNF 19922639 117859 Regulation CTGF TNF 19922639 117860 Regulation CTGF TNF 19922639 117876 Regulation CTGF TNF 19922639 117879 Regulation CTGF TNF 22675458 2648565 Regulation CTGF TNF 22675458 2648569 Regulation CTGF TNF 23029004 2694104 Regulation CTGF TNF 23029004 2694105 Regulation CTGF TNF 24015193 2842205 Regulation CTGF TNF 24734020 953853 Regulation CTGF TP53 22802911 2219405 Regulation CTGF TRIM33 22978413 292455 Regulation CTGF VEGFA 11806848 3103650 Regulation CTGF VEGFA 21986574 13476 Regulation CTGF WNT1 20299474 713217 Regulation CTGF WNT1 20299474 713218 Regulation CTGF WNT1 20299474 713219 Regulation CTGF WNT1 20299474 713220 Regulation CTGF WNT1 20299474 713275 Regulation CTGF WNT11 20299474 713221 Regulation CTGF WNT11 20299474 713222 Regulation CTGF WNT11 20299474 713223 Regulation CTGF WNT11 20299474 713224 Regulation CTGF WNT11 20299474 713276 Regulation CTGF WNT16 20299474 713250 Regulation CTGF WNT16 20299474 713251 Regulation CTGF WNT16 20299474 713252 Regulation CTGF WNT16 20299474 713253 Regulation CTGF WNT16 20299474 713281 Regulation CTGF WNT2 20299474 713225 Regulation CTGF WNT2 20299474 713226 Regulation CTGF WNT2 20299474 713227 Regulation CTGF WNT2 20299474 713228 Regulation CTGF WNT2 20299474 713277 Regulation CTGF WNT3 20299474 713229 Regulation CTGF WNT3 20299474 713230 Regulation CTGF WNT3 20299474 713231 Regulation CTGF WNT3 20299474 713232 Regulation CTGF WNT3 20299474 713278 Regulation CTGF WNT3A 24124596 2866260 Regulation CTGF WNT4 20299474 713233 Regulation CTGF WNT4 20299474 713234 Regulation CTGF WNT4 20299474 713235 Regulation CTGF WNT4 20299474 713236 Regulation CTGF WNT4 20299474 713279 Regulation CTGF WNT6 20299474 713237 Regulation CTGF WNT6 20299474 713238 Regulation CTGF WNT6 20299474 713239 Regulation CTGF WNT6 20299474 713240 Regulation CTGF WNT6 20299474 713280 Regulation CTLA4 TNF 25379363 212534 Regulation CTNNA1 TSPAN1 14691142 1303105 Regulation CTNNAL1 LEF1 22359570 2597675 Regulation CTNNAL1 LEF1 22359570 2597676 Regulation CTNNAL1 LEF1 22359570 2597683 Regulation CTNNAL1 LEF1 22359570 2597689 Regulation CTNNAL1 TFAP2A 22359570 2597673 Regulation CTNNAL1 TFAP2A 22359570 2597674 Regulation CTNNAL1 TFAP2A 22359570 2597682 Regulation CTNNAL1 TFAP2A 22359570 2597688 Regulation CTNNB1 AXIN2 24586908 2928382 Regulation CTNNBL1 TNF 17047286 1740572 Regulation CTNND1 MAP2K6 20041180 2435864 Regulation CTNND1 TSPAN1 14691142 1303127 Regulation CTR9 ARSA 18475637 1745104 Regulation CTR9 LPCAT1 25415055 177556 Regulation CTR9 TNF 3119758 1580155 Regulation CTR9 TNF 3119758 1580156 Regulation CTR9 TNF 3119758 1580179 Regulation CTSB AGR2 24717913 2950409 Regulation CTSB CST6 20074384 255199 Regulation CTSB TNF 25526565 1136160 Regulation CTSD AGR2 24717913 2950410 Regulation CTSG PPBP 24597571 1872459 Regulation CTSK ITGAL 25520721 921531 Regulation CTSK SPHK1 25534583 3148494 Regulation CTSL CST6 23305363 693864 Regulation CTSZ ITGB2 24133391 3092488 Regulation CUL1 TNF 25071782 913485 Regulation CX3CL1 EPHB2 19840952 513496 Regulation CX3CL1 TLR7 23582326 517169 Regulation CX3CL1 TNF 22096344 1628224 Regulation CX3CL1 TNF 22096344 1628225 Regulation CX3CL1 TNF 22096344 1628232 Regulation CX3CL1 TNF 22096344 1628239 Regulation CXCL1 S1PR3 21887342 2549375 Regulation CXCL1 S1PR3 21887342 2549399 Regulation CXCL1 SPHK1 22096344 1628233 Regulation CXCL1 TNF 23800251 1627109 Regulation CXCL1 TNF 23800251 1627147 Regulation CXCL1 TNF 24595131 2930799 Regulation CXCL1 TP63 22606349 2643330 Regulation CXCL10 EPHB2 23034049 3113215 Regulation CXCL10 MIP 22132075 2573991 Regulation CXCL10 TLR7 20821041 1491422 Regulation CXCL10 TNF 11879548 98696 Regulation CXCL10 TNF 18046562 1072331 Regulation CXCL10 TNF 18046562 1072332 Regulation CXCL10 TNF 18046562 1072365 Regulation CXCL10 TNF 18046562 1072366 Regulation CXCL10 TNF 19442267 1696245 Regulation CXCL10 TNF 19479051 2417549 Regulation CXCL10 TNF 22022590 2563987 Regulation CXCL10 TNF 22022590 2563988 Regulation CXCL10 TNF 22132075 2573981 Regulation CXCL10 TNF 23029004 2694110 Regulation CXCL10 TNF 23824685 2809246 Regulation CXCL10 TNF 23882269 908247 Regulation CXCL10 TNF 24516541 2921106 Regulation CXCL10 TP63 22606349 2643327 Regulation CXCL11 TNF 16033640 3105170 Regulation CXCL11 TNF 24516541 2921108 Regulation CXCL12 EPHB2 24929539 1234206 Regulation CXCL12 TNF 18371213 110346 Regulation CXCL12 TNF 18371213 110347 Regulation CXCL16 TNF 23800251 1627085 Regulation CXCL16 TNF 23800251 1627127 Regulation CXCL16 TNF 23800251 1627146 Regulation CXCL16 TNF 24130892 2867516 Regulation CXCL16 TNF 24460887 734561 Regulation CXCL2 F3 18755030 324110 Regulation CXCL2 TLR7 18584038 3072625 Regulation CXCL2 TLR7 18584038 3072710 Regulation CXCL2 TLR7 18584038 3072711 Regulation CXCL2 TLR7 18584038 3073496 Regulation CXCL2 TLR7 18584038 3073567 Regulation CXCL2 TNF 20001970 147380 Regulation CXCL2 TNF 23800251 1627098 Regulation CXCL3 TNF 23800251 1627111 Regulation CXCL3 TNF 23800251 1627149 Regulation CXCL5 F2R 21029417 354008 Regulation CXCL9 TLR7 15154616 630286 Regulation CXCL9 TLR7 23110209 2707104 Regulation CXCL9 TNF 11696601 1521796 Regulation CXCL9 TNF 15154616 630250 Regulation CXCL9 TNF 24516541 2921110 Regulation CXCR1 ANGPT1 22152684 124453 Regulation CXCR2 ANGPT1 22152684 124455 Regulation CXCR2 IFI27 22397681 1698174 Regulation CXCR2 TLR7 22566963 900607 Regulation CXCR2 TNF 18268919 1071590 Regulation CXCR4 CDKN1C 18378795 1550251 Regulation CXCR4 EPHB2 21909361 2550683 Regulation CXCR4 EPHB2 25514788 3034644 Regulation CXCR4 EPHB2 25514788 3034645 Regulation CXCR4 EPHB2 25514788 3034665 Regulation CXCR4 EPHB2 25514788 3034669 Regulation CXCR4 EPHB2 25514788 3034676 Regulation CXCR4 EPHB2 25514788 3034708 Regulation CXCR4 FOXO1 21143873 331794 Regulation CXCR4 ID1 22139302 1879456 Regulation CXCR4 KLF9 18783612 3096697 Regulation CXCR4 NR2F1 24906407 273673 Regulation CXCR4 PTGER2 20705717 1885428 Regulation CXCR4 PTGER2 20705717 1885485 Regulation CXCR4 TLR7 22745793 2656553 Regulation CXCR4 TNF 18371213 110348 Regulation CXCR4 TNF 18371213 110349 Regulation CXCR4 TNF 20699000 257077 Regulation CXCR4 TNF 20699000 257078 Regulation CXCR4 TNF 21508508 736874 Regulation CXCR4 TNF 23800251 1627158 Regulation CXCR4 TNF 25527973 1736358 Regulation CXCR5 TNF 23800251 1627123 Regulation CXCR5 TNF 9892622 1605089 Regulation CYBB TLR7 24098562 2858168 Regulation CYCS CAPN8 24709649 616929 Regulation CYCS CEACAM6 23021083 1867030 Regulation CYCS EPHB2 23470533 560769 Regulation CYCS MMP28 19714247 2424928 Regulation CYCS MMP7 19714247 2424943 Regulation CYCS TGM2 20665636 774905 Regulation CYCS TNFSF10 17718901 1645620 Regulation CYCS TNFSF10 20661217 2133106 Regulation CYLD PDE4B 23575688 1935966 Regulation CYLD PDE4B 23575688 1935970 Regulation CYLD PDE4B 23575688 1935971 Regulation CYLD PDE4B 23575688 1935973 Regulation CYLD TNF 22297296 554132 Regulation CYLD TNF 24098568 2858189 Regulation CYP11B2 F2R 20204133 1213969 Regulation CYP17A1 MAP2K6 19917087 1676338 Regulation CYP19A1 CCND1 24848372 2972406 Regulation CYP19A1 TNF 22125453 3152139 Regulation CYP1A1 IL1B 12204817 791188 Regulation CYP1A1 TNF 22866165 1239688 Regulation CYP1A2 IL1B 12204817 791191 Regulation CYP1B1 TNF 22866165 1239689 Regulation CYP24A1 CYP3A4 24924803 2979750 Regulation CYP24A1 IGFBP3 24782782 964719 Regulation CYP24A1 MAP2K1 22272032 1694230 Regulation CYP24A1 MAP2K2 22272032 1694231 Regulation CYP24A1 MAP2K3 22272032 1694232 Regulation CYP24A1 MAP2K4 22272032 1694233 Regulation CYP24A1 MAP2K5 22272032 1694234 Regulation CYP24A1 MAP2K6 22272032 1694235 Regulation CYP24A1 MAP2K7 22272032 1694236 Regulation CYP24A1 PRDX2 22940288 1691540 Regulation CYP24A1 VDR 19240808 2014632 Regulation CYP24A1 VDR 23119081 2712704 Regulation CYP24A1 VDR 24782782 964718 Regulation CYP2A6 MAP2K6 22530035 2620990 Regulation CYP3A4 TNF 19240808 2014677 Regulation CYR61 F3 23535544 3134657 Regulation CYTIP ITGAL 23469018 2760666 Regulation DACH1 FOXO1 21143873 331768 Regulation DAPK1 CA2 PMC4033950 2245765 Regulation DAPK1 CALM3 24106480 962463 Regulation DAPK1 CDR1 22246465 2170867 Regulation DAPK1 CEBPA 25140166 927254 Regulation DAPK1 GADD45A 24216985 500738 Regulation DAPK1 HDAC1 12087472 421758 Regulation DAPK1 HDAC10 12087472 421756 Regulation DAPK1 HDAC11 12087472 421757 Regulation DAPK1 HDAC2 12087472 421759 Regulation DAPK1 HDAC3 12087472 421760 Regulation DAPK1 HDAC4 12087472 421751 Regulation DAPK1 HDAC5 12087472 421755 Regulation DAPK1 HDAC6 12087472 421752 Regulation DAPK1 HDAC7 12087472 421754 Regulation DAPK1 HDAC8 12087472 421750 Regulation DAPK1 HDAC9 12087472 421753 Regulation DAPK1 MYLIP 23717626 2798519 Regulation DAPK1 MYLIP 24735923 479736 Regulation DAPK1 NAB1 22160140 2170568 Regulation DAPK1 NAB2 22160140 2170569 Regulation DAPK1 NEUROD1 24853415 575985 Regulation DAPK1 NEUROD2 24853415 575986 Regulation DAPK1 NEUROD4 24853415 575983 Regulation DAPK1 NEUROD6 24853415 575984 Regulation DAPK1 PIN1 24853415 575974 Regulation DAPK1 PRDX2 20048748 8916 Regulation DAPK1 UTRN 23880846 1108916 Regulation DAXX FAS 14612908 423779 Regulation DBH FOXO1 25353004 1888787 Regulation DBH FOXO1 25353004 1888789 Regulation DBP ANGPT1 24160568 295258 Regulation DCP1A EPHB2 23637887 2786604 Regulation DDIT3 FOXO1 24475223 2915273 Regulation DDX20 CAPN8 21209906 2492187 Regulation DDX20 SMN2 10601333 1253848 Regulation DDX21 MAP2K6 25260534 475739 Regulation DDX3X CCND1 25538732 897174 Regulation DDX58 TLR7 21079690 3049437 Regulation DEFA1B ITGB2 7686213 1591516 Regulation DEFA1B JAG1 24971082 913148 Regulation DEFA1B TNF 20525314 119112 Regulation DEFB103A CD14 23390582 3134183 Regulation DEFB4B CD14 23046822 1698887 Regulation DEFB4B TLR7 23554537 3630 Regulation DEFB4B TLR7 23554537 3650 Regulation DEFB4B TLR7 25079443 1128834 Regulation DES TNF 18519735 1352450 Regulation DGAT2 FOXA1 22238690 2587083 Regulation DGCR8 TP63 25168241 549174 Regulation DHFR AXIN2 19727391 2425643 Regulation DIABLO MAP2K6 23056924 140505 Regulation DIABLO TNF 21738708 2533442 Regulation DIABLO TNFSF10 17718901 1645622 Regulation DIABLO TNFSF10 21364655 549976 Regulation DIABLO TNFSF10 21364655 549984 Regulation DIABLO TNFSF10 21364655 550004 Regulation DIABLO TNFSF10 21364655 550006 Regulation DIANPH SPON2 22235198 832501 Regulation DIAPH1 EPHB2 23325789 1811331 Regulation DIO1 SYNM 19138393 2112420 Regulation DIO1 SYNM 19138393 2112421 Regulation DIO1 TNF 20808947 2473082 Regulation DIO2 TNF 20808947 2473083 Regulation DIO3 TNF 20808947 2473084 Regulation DISC1 FAS 21151158 12251 Regulation DISC1 FAS 24204853 2874460 Regulation DISC1 MUC16 24690311 272541 Regulation DISC1 TNFSF10 18992144 251788 Regulation DISC1 TNFSF10 21049020 2480462 Regulation DISC1 TNFSF10 21738740 2533577 Regulation DISC2 FAS 21151158 12254 Regulation DISC2 FAS 24204853 2874461 Regulation DISC2 MUC16 24690311 272542 Regulation DISC2 TNFSF10 18992144 251789 Regulation DISC2 TNFSF10 21049020 2480464 Regulation DISC2 TNFSF10 21738740 2533578 Regulation DKC1 ETV7 22291956 2591380 Regulation DKC1 ZFP57 25032857 577547 Regulation DKK1 CLU 23164821 1901016 Regulation DKK1 CLU 23164821 1901017 Regulation DKK1 MSX1 25545010 3036115 Regulation DKK1 MSX1 25545010 3036225 Regulation DKK1 TNF 18001488 109433 Regulation DKK1 TNF 24250816 2881715 Regulation DKK1 TNF 24250816 2881725 Regulation DKK1 TNF 24432364 131315 Regulation DKK1 TNF 25228904 914164 Regulation DKK1 TNF 25228904 914186 Regulation DKK1 TNF PMC3007788 1702489 Regulation DLG1 FAS 18070911 1346808 Regulation DLG2 FAS 18070911 1346809 Regulation DLG3 FAS 18070911 1346810 Regulation DLG4 CAPN8 25393018 3025402 Regulation DLG4 EPHB2 22832728 3189177 Regulation DLG4 FAS 18070911 1346811 Regulation DLG4 MAP2K6 22832728 3189183 Regulation DLG5 FAS 18070911 1346812 Regulation DLK1 EPHB2 20827342 2114921 Regulation DLL1 JAG1 21124801 2484109 Regulation DLX1 EDN2 23020903 828259 Regulation DLX2 EDN2 23020903 828262 Regulation DLX3 EDN2 23020903 828265 Regulation DLX4 EDN2 23020903 828268 Regulation DLX5 EDN2 23020903 828271 Regulation DLX6 EDN2 23020903 828274 Regulation DLX6 MSX1 23382810 2746342 Regulation DMBT1 ABCA4 23950961 2833042 Regulation DMBT1 TNF 23238132 651909 Regulation DMD TMOD1 12975349 1297086 Regulation DMD TMOD1 22013379 1222824 Regulation DMD TNF 20814569 2473446 Regulation DMP1 EPHB2 21836819 648278 Regulation DMP1 MAP2K6 21836819 648284 Regulation DNAJC5 TNF 21556142 2517730 Regulation DNAJC5 TNF 21556142 2517763 Regulation DNAJC5 TNF 23300801 2736014 Regulation DND1 RNASE1 18509452 2389826 Regulation DND1 RNASE7 18509452 2389834 Regulation DNMT1 EPHB2 22559742 398587 Regulation DNMT1 EPHB2 22559742 398597 Regulation DNMT1 EPHB2 24358134 2898647 Regulation DNMT1 FAS 23103563 154193 Regulation DNMT1 STK39 21619587 243996 Regulation DNMT3A EPHB2 21625500 2524537 Regulation DNMT3A EPHB2 21625500 2524538 Regulation DNMT3A EPHB2 24282625 2887143 Regulation DOCK2 TLR7 20231379 1557667 Regulation DOCK2 TLR7 20231379 1557789 Regulation DPP10 MMP28 19270735 2407123 Regulation DPP10 MMP28 19270735 2407124 Regulation DPP10 MMP7 19270735 2407153 Regulation DPP10 MMP7 19270735 2407154 Regulation DPP3 MMP28 19270735 2407167 Regulation DPP3 MMP28 19270735 2407168 Regulation DPP3 MMP7 19270735 2407197 Regulation DPP3 MMP7 19270735 2407198 Regulation DPP4 MMP28 19270735 2407211 Regulation DPP4 MMP28 19270735 2407212 Regulation DPP4 MMP7 19270735 2407241 Regulation DPP4 MMP7 19270735 2407242 Regulation DPP6 MMP28 19270735 2407255 Regulation DPP6 MMP28 19270735 2407256 Regulation DPP6 MMP7 19270735 2407285 Regulation DPP6 MMP7 19270735 2407286 Regulation DPP7 MMP28 19270735 2406991 Regulation DPP7 MMP28 19270735 2406992 Regulation DPP7 MMP7 19270735 2407021 Regulation DPP7 MMP7 19270735 2407022 Regulation DPP8 MMP28 19270735 2407035 Regulation DPP8 MMP28 19270735 2407036 Regulation DPP8 MMP7 19270735 2407065 Regulation DPP8 MMP7 19270735 2407066 Regulation DPP9 MMP28 19270735 2407079 Regulation DPP9 MMP28 19270735 2407080 Regulation DPP9 MMP7 19270735 2407109 Regulation DPP9 MMP7 19270735 2407110 Regulation DRG1 TNF 20146792 1656095 Regulation DRG2 TNF 20146792 1656096 Regulation DSC1 GJB2 24931423 1681407 Regulation DSC1 GJB4 24931423 1681409 Regulation DSC2 GJB2 24931423 1681414 Regulation DSC2 GJB4 24931423 1681416 Regulation DSC3 GJB2 24931423 1681421 Regulation DSC3 GJB4 24931423 1681423 Regulation DSG2 MMP28 22312325 696872 Regulation DSG2 MMP7 22312325 696887 Regulation DSP PKP1 10747098 1257011 Regulation DUOX2 TLR7 23349873 2743771 Regulation DUSP1 ANGPT1 24308939 1158502 Regulation DUSP1 ANGPT1 24308939 1158872 Regulation DUSP1 ANGPT1 24308939 1158873 Regulation DUSP1 ANGPT1 24308939 1158956 Regulation DUSP1 EPHB2 11435472 1519589 Regulation DUSP1 EPHB2 11435472 1519611 Regulation DUSP1 EPHB2 21253577 3050591 Regulation DUSP10 ANGPT1 24308939 1158503 Regulation DUSP10 ANGPT1 24308939 1158876 Regulation DUSP10 ANGPT1 24308939 1158957 Regulation DUSP10 EPHB2 21253577 3050604 Regulation DUSP10 TLR7 21892172 1955780 Regulation DUSP11 ANGPT1 24308939 1158504 Regulation DUSP11 ANGPT1 24308939 1158879 Regulation DUSP11 ANGPT1 24308939 1158958 Regulation DUSP11 EPHB2 21253577 3050605 Regulation DUSP12 ANGPT1 24308939 1158505 Regulation DUSP12 ANGPT1 24308939 1158882 Regulation DUSP12 ANGPT1 24308939 1158959 Regulation DUSP12 EPHB2 21253577 3050606 Regulation DUSP13 ANGPT1 24308939 1158497 Regulation DUSP13 ANGPT1 24308939 1158857 Regulation DUSP13 ANGPT1 24308939 1158949 Regulation DUSP13 EPHB2 21253577 3050581 Regulation DUSP14 ANGPT1 24308939 1158493 Regulation DUSP14 ANGPT1 24308939 1158845 Regulation DUSP14 ANGPT1 24308939 1158945 Regulation DUSP14 EPHB2 21253577 3050574 Regulation DUSP15 ANGPT1 24308939 1158492 Regulation DUSP15 ANGPT1 24308939 1158842 Regulation DUSP15 ANGPT1 24308939 1158944 Regulation DUSP15 EPHB2 21253577 3050572 Regulation DUSP16 ANGPT1 24308939 1158494 Regulation DUSP16 ANGPT1 24308939 1158848 Regulation DUSP16 ANGPT1 24308939 1158946 Regulation DUSP16 EPHB2 21253577 3050575 Regulation DUSP18 ANGPT1 24308939 1158495 Regulation DUSP18 ANGPT1 24308939 1158851 Regulation DUSP18 ANGPT1 24308939 1158947 Regulation DUSP18 EPHB2 21253577 3050576 Regulation DUSP18 EPHB2 24847354 886088 Regulation DUSP19 ANGPT1 24308939 1158496 Regulation DUSP19 ANGPT1 24308939 1158854 Regulation DUSP19 ANGPT1 24308939 1158948 Regulation DUSP19 EPHB2 21253577 3050580 Regulation DUSP2 ANGPT1 24308939 1158506 Regulation DUSP2 ANGPT1 24308939 1158885 Regulation DUSP2 ANGPT1 24308939 1158960 Regulation DUSP2 EPHB2 21253577 3050608 Regulation DUSP21 ANGPT1 24308939 1158498 Regulation DUSP21 ANGPT1 24308939 1158860 Regulation DUSP21 ANGPT1 24308939 1158950 Regulation DUSP21 EPHB2 21253577 3050582 Regulation DUSP22 ANGPT1 24308939 1158491 Regulation DUSP22 ANGPT1 24308939 1158839 Regulation DUSP22 ANGPT1 24308939 1158943 Regulation DUSP22 EPHB2 21253577 3050571 Regulation DUSP23 ANGPT1 24308939 1158499 Regulation DUSP23 ANGPT1 24308939 1158863 Regulation DUSP23 ANGPT1 24308939 1158951 Regulation DUSP23 EPHB2 21253577 3050583 Regulation DUSP26 ANGPT1 24308939 1158501 Regulation DUSP26 ANGPT1 24308939 1158869 Regulation DUSP26 ANGPT1 24308939 1158955 Regulation DUSP26 EPHB2 21253577 3050586 Regulation DUSP27 ANGPT1 24308939 1158500 Regulation DUSP27 ANGPT1 24308939 1158866 Regulation DUSP27 ANGPT1 24308939 1158954 Regulation DUSP27 EPHB2 21253577 3050585 Regulation DUSP28 ANGPT1 24308939 1158514 Regulation DUSP28 ANGPT1 24308939 1158911 Regulation DUSP28 ANGPT1 24308939 1158968 Regulation DUSP28 EPHB2 21253577 3050631 Regulation DUSP3 ANGPT1 24308939 1158507 Regulation DUSP3 ANGPT1 24308939 1158888 Regulation DUSP3 ANGPT1 24308939 1158961 Regulation DUSP3 EPHB2 21253577 3050621 Regulation DUSP4 ANGPT1 24308939 1158508 Regulation DUSP4 ANGPT1 24308939 1158891 Regulation DUSP4 ANGPT1 24308939 1158892 Regulation DUSP4 ANGPT1 24308939 1158962 Regulation DUSP4 EPHB2 21253577 3050622 Regulation DUSP5 ANGPT1 24308939 1158509 Regulation DUSP5 ANGPT1 24308939 1158895 Regulation DUSP5 ANGPT1 24308939 1158896 Regulation DUSP5 ANGPT1 24308939 1158963 Regulation DUSP5 EPHB2 21253577 3050623 Regulation DUSP5 EPHB2 23060802 959323 Regulation DUSP5 MAP2K6 23060802 959331 Regulation DUSP6 ANGPT1 24308939 1158510 Regulation DUSP6 ANGPT1 24308939 1158899 Regulation DUSP6 ANGPT1 24308939 1158964 Regulation DUSP6 EPHB2 18321244 145654 Regulation DUSP6 EPHB2 18321244 145655 Regulation DUSP6 EPHB2 21253577 3050624 Regulation DUSP6 EPHB2 22848439 2668995 Regulation DUSP6 RGS16 16012519 426298 Regulation DUSP6 TP63 23246965 2151192 Regulation DUSP7 ANGPT1 24308939 1158511 Regulation DUSP7 ANGPT1 24308939 1158902 Regulation DUSP7 ANGPT1 24308939 1158965 Regulation DUSP7 EPHB2 21253577 3050625 Regulation DUSP8 ANGPT1 24308939 1158512 Regulation DUSP8 ANGPT1 24308939 1158905 Regulation DUSP8 ANGPT1 24308939 1158966 Regulation DUSP8 EPHB2 21253577 3050626 Regulation DUSP9 ANGPT1 24308939 1158513 Regulation DUSP9 ANGPT1 24308939 1158908 Regulation DUSP9 ANGPT1 24308939 1158967 Regulation DUSP9 EPHB2 21253577 3050627 Regulation DUT CAPN8 21625588 2524848 Regulation DUT CD14 22566960 900544 Regulation DYRK1B EPHB2 23311607 482708 Regulation DYRK1B MAP2K6 23311607 482714 Regulation E2F1 CCND1 21799732 2538394 Regulation E2F1 CTGF 23902294 344811 Regulation EBF1 ZFP57 23569325 1571563 Regulation EBP FOXO1 21915332 2553363 Regulation ECM1 CD14 19710907 2424814 Regulation ECM1 CD14 19710907 2424820 Regulation ECM1 CD14 23133375 3059959 Regulation ECM1 CTGF 17224075 279454 Regulation ECM1 CTGF 17224075 279455 Regulation ECM1 CTGF 17224075 279458 Regulation ECM1 CTGF 17224075 279462 Regulation ECM1 CTGF 17224075 279470 Regulation ECM1 CTGF 22329991 1567355 Regulation ECM1 CTGF 22329991 1567426 Regulation ECM1 CTGF 22363445 2599078 Regulation ECM1 CTGF 22363445 2599082 Regulation ECM1 CTGF 22511849 1914261 Regulation ECM1 CTGF 22802911 2219381 Regulation ECM1 CTGF 23717689 2798754 Regulation ECM1 CTGF 23717689 2798762 Regulation ECM1 CTGF 23946690 1716043 Regulation ECM1 CTGF 23946690 1716044 Regulation ECM1 CTGF 23946690 1716074 Regulation ECM1 CTGF 23946690 1716132 Regulation ECM1 CTGF 23950936 2832987 Regulation ECM1 CTGF 23950936 2832999 Regulation ECM1 CTGF 24998426 297451 Regulation ECM1 CTGF 25237397 857001 Regulation ECM1 EPHB2 19144181 112540 Regulation ECM1 EPHB2 20624296 1228559 Regulation ECM1 EPHB2 24428157 1482613 Regulation ECM1 FAS 22291036 1394908 Regulation ECM1 IFI27 9026502 1459206 Regulation ECM1 LAMB3 22536154 3056437 Regulation ECM1 LAMB3 22536154 3056449 Regulation ECM1 MAP2K6 19144181 112546 Regulation ECM1 MMP28 12085210 421698 Regulation ECM1 MMP28 19090960 112119 Regulation ECM1 MMP28 22495609 1035911 Regulation ECM1 MMP28 24040310 2846463 Regulation ECM1 MMP28 24070030 388782 Regulation ECM1 MMP28 24098445 2856392 Regulation ECM1 MMP28 25530657 738511 Regulation ECM1 MMP7 12085210 421713 Regulation ECM1 MMP7 19090960 112134 Regulation ECM1 MMP7 22495609 1035926 Regulation ECM1 MMP7 24040310 2846478 Regulation ECM1 MMP7 24070030 388797 Regulation ECM1 MMP7 24098445 2856407 Regulation ECM1 MMP7 25530657 738526 Regulation ECM1 PLAT 23544048 2773399 Regulation ECM1 PLAU 18686734 1071628 Regulation ECM1 PLAU 18922176 251685 Regulation ECM1 PLAU 22131991 1673228 Regulation ECM1 PLAU 22296682 263403 Regulation ECM1 PLAU 23243599 2161903 Regulation ECM1 PLAU 23544048 2773400 Regulation ECM1 PLAU 24348274 2354265 Regulation ECM1 PLAU 25036034 1128423 Regulation ECM1 PLAU 25506199 490193 Regulation ECM1 PTGER2 25327961 216611 Regulation ECM1 SRGN 21880179 623911 Regulation ECM1 TLR7 18612394 2392693 Regulation ECM1 TNF 19087346 3109088 Regulation ECM1 TNF 8666673 1452093 Regulation ECM2 CD14 19710907 2424815 Regulation ECM2 CD14 19710907 2424821 Regulation ECM2 CD14 23133375 3059960 Regulation ECM2 CTGF 17224075 279456 Regulation ECM2 CTGF 17224075 279457 Regulation ECM2 CTGF 17224075 279459 Regulation ECM2 CTGF 17224075 279463 Regulation ECM2 CTGF 17224075 279471 Regulation ECM2 CTGF 22329991 1567356 Regulation ECM2 CTGF 22329991 1567427 Regulation ECM2 CTGF 22363445 2599079 Regulation ECM2 CTGF 22363445 2599083 Regulation ECM2 CTGF 22511849 1914262 Regulation ECM2 CTGF 22802911 2219382 Regulation ECM2 CTGF 23717689 2798755 Regulation ECM2 CTGF 23717689 2798763 Regulation ECM2 CTGF 23946690 1716045 Regulation ECM2 CTGF 23946690 1716046 Regulation ECM2 CTGF 23946690 1716075 Regulation ECM2 CTGF 23946690 1716133 Regulation ECM2 CTGF 23950936 2832988 Regulation ECM2 CTGF 23950936 2833000 Regulation ECM2 CTGF 24998426 297452 Regulation ECM2 CTGF 25237397 857002 Regulation ECM2 EPHB2 19144181 112548 Regulation ECM2 EPHB2 20624296 1228563 Regulation ECM2 EPHB2 24428157 1482614 Regulation ECM2 FAS 22291036 1394912 Regulation ECM2 IFI27 9026502 1459208 Regulation ECM2 LAMB3 22536154 3056440 Regulation ECM2 LAMB3 22536154 3056452 Regulation ECM2 MAP2K6 19144181 112554 Regulation ECM2 MMP28 12085210 421720 Regulation ECM2 MMP28 19090960 112141 Regulation ECM2 MMP28 22495609 1035933 Regulation ECM2 MMP28 24040310 2846485 Regulation ECM2 MMP28 24070030 388804 Regulation ECM2 MMP28 24098445 2856414 Regulation ECM2 MMP28 25530657 738533 Regulation ECM2 MMP7 12085210 421735 Regulation ECM2 MMP7 19090960 112156 Regulation ECM2 MMP7 22495609 1035948 Regulation ECM2 MMP7 24040310 2846500 Regulation ECM2 MMP7 24070030 388819 Regulation ECM2 MMP7 24098445 2856429 Regulation ECM2 MMP7 25530657 738548 Regulation ECM2 PLAT 23544048 2773401 Regulation ECM2 PLAU 18686734 1071629 Regulation ECM2 PLAU 18922176 251686 Regulation ECM2 PLAU 22131991 1673230 Regulation ECM2 PLAU 22296682 263404 Regulation ECM2 PLAU 23243599 2161904 Regulation ECM2 PLAU 23544048 2773402 Regulation ECM2 PLAU 24348274 2354267 Regulation ECM2 PLAU 25036034 1128424 Regulation ECM2 PLAU 25506199 490194 Regulation ECM2 PTGER2 25327961 216612 Regulation ECM2 SRGN 21880179 623912 Regulation ECM2 TLR7 18612394 2392703 Regulation ECM2 TNF 19087346 3109090 Regulation ECM2 TNF 8666673 1452094 Regulation EDIL3 TNF 24416060 639488 Regulation EDN1 CTGF 24015303 2842674 Regulation EDN1 EPHB2 25136830 2999089 Regulation EDN1 FOXO1 24077237 2118298 Regulation EDN1 GPNMB 23884103 220668 Regulation EDN1 LBP 23094016 2705934 Regulation EDN1 MAP2K6 24823877 1126525 Regulation EDN1 RGS2 22802950 2663755 Regulation EDN1 SPHK1 24586752 2926306 Regulation EDN1 TNF 18475471 1743853 Regulation EDN1 TNF 18475471 1743854 Regulation EDN1 TNF 19272191 1227087 Regulation EDN1 TNF 21253506 1748722 Regulation EDN1 TNF 23565184 2777060 Regulation EDN1 TNF 23565184 2777069 Regulation EDN2 ACTA2 23592914 1915842 Regulation EDN2 ADRBK1 20705669 513767 Regulation EDN2 BMP6 16594992 274389 Regulation EDN2 CCL2 20937084 1657172 Regulation EDN2 CROT 20844572 1911983 Regulation EDN2 CXCR3 22004287 3112822 Regulation EDN2 DLX1 23020903 828282 Regulation EDN2 DLX2 23020903 828283 Regulation EDN2 DLX3 23020903 828284 Regulation EDN2 DLX4 23020903 828285 Regulation EDN2 DLX5 23020903 828286 Regulation EDN2 DLX6 23020903 828287 Regulation EDN2 ECE1 10352019 1246647 Regulation EDN2 EDN1 18778461 274644 Regulation EDN2 EDN1 19775468 379353 Regulation EDN2 EDN3 24040226 2846195 Regulation EDN2 EDNRB 18778461 274555 Regulation EDN2 EDNRB 18778461 274590 Regulation EDN2 ERAS 25305681 1065752 Regulation EDN2 GAPDH 24282406 969857 Regulation EDN2 GNAQ 21773036 1690232 Regulation EDN2 HMOX1 23691261 2225840 Regulation EDN2 IL1A 21477368 3112052 Regulation EDN2 IL6 20937084 1657173 Regulation EDN2 MAPK1 18778461 274591 Regulation EDN2 MAPK10 18778461 274592 Regulation EDN2 MAPK11 18778461 274593 Regulation EDN2 MAPK12 18778461 274594 Regulation EDN2 MAPK13 18778461 274595 Regulation EDN2 MAPK14 18778461 274596 Regulation EDN2 MAPK15 18778461 274589 Regulation EDN2 MAPK3 18778461 274597 Regulation EDN2 MAPK4 18778461 274598 Regulation EDN2 MAPK6 18778461 274599 Regulation EDN2 MAPK7 18778461 274600 Regulation EDN2 MAPK8 18778461 274601 Regulation EDN2 MAPK9 18778461 274602 Regulation EDN2 SETD2 22874467 834882 Regulation EDN2 SMARCAD1 20844572 1911982 Regulation EDN2 SOX10 24040226 2846194 Regulation EDN2 TNF 18475471 1743855 Regulation EDN2 WNT1 24348512 885312 Regulation EDN2 WNT11 24348512 885313 Regulation EDN2 WNT16 24348512 885318 Regulation EDN2 WNT2 24348512 885314 Regulation EDN2 WNT3 24348512 885315 Regulation EDN2 WNT4 24348512 885316 Regulation EDN2 WNT6 24348512 885317 Regulation EDN3 TNF 18475471 1743856 Regulation EDNRA EDN2 25210474 1680349 Regulation EDNRB EDN2 18778461 274558 Regulation EDNRB EDN2 18778461 274619 Regulation EDNRB EDN2 25210474 1680352 Regulation EDNRB FHL1 24516350 1085059 Regulation EDNRB MAP2K6 24886705 1668176 Regulation EEF2K EPHB2 24478645 861079 Regulation EFNB1 IFIT2 20565770 360380 Regulation EFNB1 IL1A 20979661 1897749 Regulation EFNB1 INS 24098442 2856371 Regulation EFNB1 PIK3CA 22879882 2672860 Regulation EFNB1 PIK3R1 22879882 2672861 Regulation EFNB1 PTH 18797510 1083997 Regulation EFNB1 PTPN13 22279592 2590862 Regulation EFNB1 PTPN13 22279592 2590864 Regulation EFNB1 RGS3 25250016 881188 Regulation EFNB1 SRC 22279592 2590851 Regulation EFNB1 SRC 22279592 2590856 Regulation EFNB1 TNF 24098442 2856365 Regulation EFS TNF 11238593 1519016 Regulation EGF EPHB2 16914058 242027 Regulation EGF HBEGF 22792252 2661566 Regulation EGF HBEGF 25344915 2206132 Regulation EGF IFI27 23573293 2778205 Regulation EGF MMP28 23226927 1751043 Regulation EGF MMP7 23226927 1751058 Regulation EGF MUC16 23857061 1108560 Regulation EGF NR2F1 24906407 273659 Regulation EGFR CTGF 23175185 548175 Regulation EGFR EPHB2 17449939 1634814 Regulation EGFR EPHB2 22649008 778728 Regulation EGFR EPHB2 22785133 1631024 Regulation EGFR EPHB2 22984397 2688270 Regulation EGFR EPHB2 23829771 410461 Regulation EGFR EPHB2 23991110 2840957 Regulation EGFR EPHB2 25421240 1135085 Regulation EGFR F2R 20723226 257139 Regulation EGFR HBEGF 11250708 456343 Regulation EGFR HBEGF 15827558 425507 Regulation EGFR HBEGF 20195469 2441964 Regulation EGFR HBEGF 21946538 1961674 Regulation EGFR HBEGF 21997136 437934 Regulation EGFR HBEGF 22087246 2570701 Regulation EGFR HBEGF 22110740 2573128 Regulation EGFR HBEGF 22747893 1664303 Regulation EGFR HBEGF 23344022 1100588 Regulation EGFR HBEGF 23991110 2840951 Regulation EGFR HBEGF 25249545 2201893 Regulation EGFR HBEGF 25421240 1135188 Regulation EGFR ID1 15599381 425168 Regulation EGFR ID1 15599381 425169 Regulation EGFR ID1 15599381 425170 Regulation EGFR ID1 19014499 1503385 Regulation EGFR MAP2K6 20877637 2475421 Regulation EGFR MMP28 22792188 2661475 Regulation EGFR MMP28 24132149 1113479 Regulation EGFR MMP28 25261977 1510593 Regulation EGFR MMP28 25421240 1135084 Regulation EGFR MMP7 22792188 2661491 Regulation EGFR MMP7 24132149 1113494 Regulation EGFR MMP7 25261977 1510618 Regulation EGFR MMP7 25421240 1135103 Regulation EGFR NR2F1 24906407 273660 Regulation EGFR NT5E 25126561 196704 Regulation EGFR RAB31 25472813 1486009 Regulation EGFR RAB31 25472813 1486019 Regulation EGFR RCAN1 19603121 1832626 Regulation EGFR S100A7 18320059 2384876 Regulation EGFR S100A7 18320059 2384881 Regulation EGFR S100A7 18534028 463009 Regulation EGFR S1PR3 16636149 1329274 Regulation EGFR S1PR3 16636149 1329293 Regulation EGFR SPHK1 16636149 1329267 Regulation EGFR SPHK1 16636149 1329268 Regulation EGFR SPHK1 16636149 1329269 Regulation EGFR SPHK1 16636149 1329270 Regulation EGFR SPHK1 24970177 208694 Regulation EGFR SPHK1 24970177 208695 Regulation EGFR SPHK1 24970177 208799 Regulation EGFR TNF 11686870 3102970 Regulation EGFR TNF 22988345 1750572 Regulation EGLN1 ANGPT1 23737442 780960 Regulation EGLN2 EGLN3 25161887 1888480 Regulation EGLN2 TNF PMC4212304 3206291 Regulation EGLN3 EDN1 20574527 2453495 Regulation EGLN3 HIF1AN 20967267 2478620 Regulation EGLN3 NFKB1 24236059 2878328 Regulation EGLN3 RELA 24236059 2878329 Regulation EGLN3 SETD2 17387348 429028 Regulation EGLN3 SETD2 19308685 495170 Regulation EGLN3 SETD2 19473554 113370 Regulation EGLN3 SETD2 19473554 113372 Regulation EGLN3 SETD2 20967267 2478617 Regulation EGLN3 SIAH1 18047745 226244 Regulation EGLN3 SIAH1 24809345 2358890 Regulation EGLN3 SIAH1 24809345 2358963 Regulation EGLN3 SIAH2 18047745 226245 Regulation EGLN3 SIAH2 24809345 2358891 Regulation EGLN3 SIAH2 24809345 2358964 Regulation EGLN3 SLC22A3 24367580 2900248 Regulation EGLN3 ZEB1 24367580 2900249 Regulation EGR1 CTGF 23946690 1716125 Regulation EGR1 EPHB2 18615184 3074353 Regulation EGR1 EPHB2 19144181 112447 Regulation EGR1 EPHB2 21559295 2518074 Regulation EGR1 EPHB2 23469182 2762878 Regulation EGR1 EPHB2 23624917 2152162 Regulation EGR1 EPHB2 24089634 1160619 Regulation EGR1 EPHB2 25004251 2195473 Regulation EGR1 EPHB2 25243776 3008782 Regulation EGR1 F3 23535544 3134658 Regulation EGR1 MAP2K6 19144181 112453 Regulation EGR1 MMP28 22792188 2661393 Regulation EGR1 MMP7 22792188 2661430 Regulation EGR1 TLR7 19997504 3045767 Regulation EGR1 TNF 18472825 1741868 Regulation EGR1 TNF 21619646 3214116 Regulation EGR1 TNF 7843095 796612 Regulation EGR2 MAP2K6 22049075 1193839 Regulation EIF2AK1 TLR7 PMC3353446 35120 Regulation EIF2AK2 TNF 21699726 1658629 Regulation EIF4E EPHB2 22267161 1967399 Regulation EIF4E EPHB2 22319481 860830 Regulation EIF4EBP1 CCND1 21695126 2529420 Regulation EIF4EBP1 EPHB2 22530122 2009484 Regulation EIF4G2 EPHB2 11425867 1271713 Regulation ELANE HES2 PMC4095460 661336 Regulation ELAVL1 TNF 20459669 3118925 Regulation ELK1 EPHB2 21441990 936219 Regulation ELK1 EPHB2 21441990 936238 Regulation ELK1 EPHB2 21441990 936240 Regulation ELK1 EPHB2 23158473 1867285 Regulation ELK1 EPHB2 23823477 590347 Regulation ELK4 EPHB2 12204819 791201 Regulation ELL ANO1 24694595 1823302 Regulation ELL ELOVL4 21139992 1912422 Regulation ELL ELOVL4 21139992 1912424 Regulation ELL ELOVL4 24569140 1637955 Regulation ELL ELOVL4 24571530 361216 Regulation ELL EPHB2 23741474 2801187 Regulation ELL EPHB2 24260264 2883593 Regulation ELL EPHB2 24587210 2929065 Regulation ELL FHL1 18611274 281582 Regulation ELL FOXO1 19555482 235801 Regulation ELL ITGAL 22711877 1568401 Regulation ELL LINC00284 24843027 757617 Regulation ELL LINC00341 24843027 757577 Regulation ELL MAP2K6 24260264 2883602 Regulation ELL NGFR 20156358 402378 Regulation ELL SARM1 21555464 1386915 Regulation ELL SRGN 20032306 1772594 Regulation ELL TMOD1 19752024 1367931 Regulation ELL TMOD1 20737540 694953 Regulation ELL TMOD1 7798317 1441697 Regulation ELL TNF 22615129 1568240 Regulation ELL TNS1 8195290 1445743 Regulation ELOVL4 CERS3 23826266 2811875 Regulation ELOVL4 CERS3 23826266 2811880 Regulation ELOVL4 HSD17B12 25003994 2987220 Regulation EMP1 SERPINA1 24743137 2954841 Regulation EMP1 SOD1 21966220 3209122 Regulation EMP1 SOD2 21966220 3209123 Regulation EMP1 SOD3 21966220 3209124 Regulation EMP1 SRC 20663135 256842 Regulation EMP1 TNF 21966220 3209125 Regulation EMP2 TNF 21966220 3209129 Regulation EMP3 TNF 21966220 3209133 Regulation ENG TNF 24558374 2923477 Regulation ENO1 CCND1 24884804 1874331 Regulation ENO2 CCND1 24884804 1874333 Regulation ENO3 CCND1 24884804 1874335 Regulation ENO4 CCND1 24884804 1874329 Regulation ENPP3 TLR7 23566714 128130 Regulation ENTPD1 IL1B 18553155 3089822 Regulation EOMES EPHB2 23776078 1572518 Regulation EPC1 EPHB2 24755675 2957203 Regulation EPC1 EPHB2 24755675 2957217 Regulation EPC1 EPHB2 25268972 3011836 Regulation EPC1 ID1 18092003 2381436 Regulation EPC1 JAG1 22487493 3207619 Regulation EPC2 EPHB2 24755675 2957204 Regulation EPC2 EPHB2 24755675 2957221 Regulation EPC2 EPHB2 25268972 3011840 Regulation EPC2 ID1 18092003 2381437 Regulation EPC2 JAG1 22487493 3207621 Regulation EPCAM TNF 24692847 1757853 Regulation EPCAM TNF 24692847 1757857 Regulation EPCAM TNF 24692847 1757858 Regulation EPHA2 MAP2K6 24103789 626348 Regulation EPHA3 EFNB1 22144690 1394363 Regulation EPHA3 EFNB1 22144690 1394365 Regulation EPHA4 EFNB1 25247423 2288126 Regulation EPHA4 EFNB1 25247423 2288182 Regulation EPHA8 RINL 22291991 2591618 Regulation EPHB1 EFNB1 23143520 1967859 Regulation EPHB1 EPHB2 21847105 1933283 Regulation EPHB2 ACD 23758320 151559 Regulation EPHB2 ACD 25629002 949896 Regulation EPHB2 ACE2 24067190 1700566 Regulation EPHB2 ACKR3 22472349 1698257 Regulation EPHB2 ACKR3 24629239 1873017 Regulation EPHB2 ACO2 21887333 2549331 Regulation EPHB2 ACO2 21887333 2549333 Regulation EPHB2 ADCY1 25352775 939269 Regulation EPHB2 ADCY10 18695009 1609085 Regulation EPHB2 ADCY10 25352775 939268 Regulation EPHB2 ADCY2 25352775 939270 Regulation EPHB2 ADCY3 25352775 939271 Regulation EPHB2 ADCY4 25352775 939272 Regulation EPHB2 ADCY5 25352775 939273 Regulation EPHB2 ADCY6 25352775 939274 Regulation EPHB2 ADCY7 25352775 939275 Regulation EPHB2 ADCY8 25352775 939276 Regulation EPHB2 ADCY9 25352775 939277 Regulation EPHB2 ADCYAP1 20062533 2436717 Regulation EPHB2 ADCYAP1 20093365 1168982 Regulation EPHB2 ADI1 23933651 18444 Regulation EPHB2 ADIPOQ 21829524 2541585 Regulation EPHB2 ADIPOQ 21829524 2541608 Regulation EPHB2 ADORA2B 18947405 361914 Regulation EPHB2 ADRBK1 23977191 2838875 Regulation EPHB2 ADRBK1 24597858 1650564 Regulation EPHB2 ADRBK1 24597858 1650580 Regulation EPHB2 ADRBK2 24597858 1650581 Regulation EPHB2 AGK 15939762 1320811 Regulation EPHB2 AHSA1 22769588 521323 Regulation EPHB2 AHSA1 23982477 93447 Regulation EPHB2 AIP 25245034 541121 Regulation EPHB2 AKT1 10974038 1517002 Regulation EPHB2 AKT1 10974038 1517014 Regulation EPHB2 AKT1 10974038 1517056 Regulation EPHB2 AKT1 16365168 1326414 Regulation EPHB2 AKT1 16365168 1326415 Regulation EPHB2 AKT1 16365168 1326424 Regulation EPHB2 AKT1 16365168 1326440 Regulation EPHB2 AKT1 17274840 997635 Regulation EPHB2 AKT1 18091994 2381371 Regulation EPHB2 AKT1 19243631 1503639 Regulation EPHB2 AKT1 21203579 2273148 Regulation EPHB2 AKT1 21283628 2497020 Regulation EPHB2 AKT1 21698152 2530537 Regulation EPHB2 AKT1 22004682 1863817 Regulation EPHB2 AKT1 22596241 438795 Regulation EPHB2 AKT1 22668349 212895 Regulation EPHB2 AKT1 22812497 292281 Regulation EPHB2 AKT1 22967907 1506586 Regulation EPHB2 AKT1 23162692 3131691 Regulation EPHB2 AKT1 23526884 2282205 Regulation EPHB2 AKT1 24424114 479053 Regulation EPHB2 AKT1 25258648 1240972 Regulation EPHB2 AKT1S1 23437362 2756655 Regulation EPHB2 AKT2 10974038 1517003 Regulation EPHB2 AKT2 10974038 1517015 Regulation EPHB2 AKT2 10974038 1517057 Regulation EPHB2 AKT2 16365168 1326446 Regulation EPHB2 AKT2 17274840 997636 Regulation EPHB2 AKT2 18091994 2381372 Regulation EPHB2 AKT2 19243631 1503640 Regulation EPHB2 AKT2 21283628 2497021 Regulation EPHB2 AKT2 21297943 2498611 Regulation EPHB2 AKT2 21698152 2530538 Regulation EPHB2 AKT2 22004682 1863818 Regulation EPHB2 AKT2 22596241 438796 Regulation EPHB2 AKT2 22668349 212896 Regulation EPHB2 AKT2 22812497 292282 Regulation EPHB2 AKT2 22967907 1506587 Regulation EPHB2 AKT2 23162692 3131692 Regulation EPHB2 AKT2 23526884 2282206 Regulation EPHB2 AKT2 24424114 479054 Regulation EPHB2 AKT2 25258648 1240973 Regulation EPHB2 AKT3 10974038 1517004 Regulation EPHB2 AKT3 10974038 1517016 Regulation EPHB2 AKT3 10974038 1517058 Regulation EPHB2 AKT3 17274840 997637 Regulation EPHB2 AKT3 18091994 2381373 Regulation EPHB2 AKT3 19243631 1503641 Regulation EPHB2 AKT3 21283628 2497022 Regulation EPHB2 AKT3 21698152 2530539 Regulation EPHB2 AKT3 22004682 1863819 Regulation EPHB2 AKT3 22596241 438797 Regulation EPHB2 AKT3 22668349 212897 Regulation EPHB2 AKT3 22812497 292283 Regulation EPHB2 AKT3 22967907 1506588 Regulation EPHB2 AKT3 23162692 3131693 Regulation EPHB2 AKT3 23526884 2282207 Regulation EPHB2 AKT3 24424114 479055 Regulation EPHB2 AKT3 25258648 1240974 Regulation EPHB2 AKTIP 22127644 92947 Regulation EPHB2 AKTIP 25593982 2172162 Regulation EPHB2 ALK 24715763 2249901 Regulation EPHB2 ALOX5 25025775 2989422 Regulation EPHB2 ANGPT2 23243430 816474 Regulation EPHB2 ANGPT2 23691054 2794177 Regulation EPHB2 ANGPT2 24827991 2969928 Regulation EPHB2 ANGPT2 25101263 195686 Regulation EPHB2 ANXA1 21635771 3084229 Regulation EPHB2 APH1A 19247475 2406540 Regulation EPHB2 APLN 21437254 2509170 Regulation EPHB2 APOB 19247493 2406630 Regulation EPHB2 APOE 17166269 1890782 Regulation EPHB2 AQP5 20806077 1911909 Regulation EPHB2 AQP5 PMC4034029 2246245 Regulation EPHB2 ARAF 16129781 1323442 Regulation EPHB2 ARC 21559295 2518076 Regulation EPHB2 ARF6 22701712 2652213 Regulation EPHB2 ARG1 21559295 2518077 Regulation EPHB2 ARG2 21559295 2518078 Regulation EPHB2 ARHGAP8 23155002 1809649 Regulation EPHB2 ARHGEF7 22216034 22207 Regulation EPHB2 ARHGEF7 22438844 951437 Regulation EPHB2 ASIC1 22216270 2585212 Regulation EPHB2 ASIC2 22216270 2585217 Regulation EPHB2 ASIC3 22216270 2585213 Regulation EPHB2 ASIC4 22216270 2585216 Regulation EPHB2 ASIC5 22216270 2585215 Regulation EPHB2 ATF6 21841811 13250 Regulation EPHB2 ATG7 24240988 1939494 Regulation EPHB2 ATG7 24240988 1939499 Regulation EPHB2 ATP5O 24351799 3223671 Regulation EPHB2 ATR 23640330 2087547 Regulation EPHB2 AXL 22141136 2176855 Regulation EPHB2 BCL10 23586039 181017 Regulation EPHB2 BCL10 23586039 181190 Regulation EPHB2 BCR 11514608 1520640 Regulation EPHB2 BCR 19897477 1167296 Regulation EPHB2 BCR 19897477 1167303 Regulation EPHB2 BCR 21441934 1955255 Regulation EPHB2 BCR 24027568 908835 Regulation EPHB2 BCR 9763608 1604084 Regulation EPHB2 BDNF 18320028 2384805 Regulation EPHB2 BDNF 20156366 255312 Regulation EPHB2 BDNF 20840753 1897672 Regulation EPHB2 BDNF 21331282 934775 Regulation EPHB2 BDNF 21849472 1793459 Regulation EPHB2 BMP2 19821774 1236721 Regulation EPHB2 BMP2 24373581 1482331 Regulation EPHB2 BMP4 18310445 1497462 Regulation EPHB2 BPNT1 22817771 471880 Regulation EPHB2 BRAF 18332218 1349917 Regulation EPHB2 BRAF 18335053 2386968 Regulation EPHB2 BRAF 19603027 432453 Regulation EPHB2 BRAF 20149136 2252477 Regulation EPHB2 BRAF 23208503 2150236 Regulation EPHB2 BRAF 23208503 2150269 Regulation EPHB2 BRAF 23658559 883847 Regulation EPHB2 BRAF 23758320 151553 Regulation EPHB2 BTK 11410123 350237 Regulation EPHB2 BTK 11410123 350238 Regulation EPHB2 BTRC 11435472 1519613 Regulation EPHB2 BTRC 23420868 2085680 Regulation EPHB2 C1GALT1 24758762 2189389 Regulation EPHB2 C1orf228 22537317 355885 Regulation EPHB2 C5 22355325 2597212 Regulation EPHB2 C5 22355325 2597215 Regulation EPHB2 CA1 23785474 2806385 Regulation EPHB2 CA2 11914123 276480 Regulation EPHB2 CA2 11914123 276519 Regulation EPHB2 CA2 12370087 225137 Regulation EPHB2 CA2 14577832 3095279 Regulation EPHB2 CA2 16278666 426767 Regulation EPHB2 CA2 16278666 426768 Regulation EPHB2 CA2 16278666 426769 Regulation EPHB2 CA2 20872847 3171033 Regulation EPHB2 CA2 21037577 1954562 Regulation EPHB2 CA2 21441934 1955205 Regulation EPHB2 CA2 21441934 1955206 Regulation EPHB2 CA2 21441934 1955207 Regulation EPHB2 CA2 21441934 1955208 Regulation EPHB2 CA2 21441934 1955209 Regulation EPHB2 CA2 21441934 1955210 Regulation EPHB2 CA2 21441934 1955211 Regulation EPHB2 CA2 21441934 1955212 Regulation EPHB2 CA2 21441934 1955219 Regulation EPHB2 CA2 21441934 1955225 Regulation EPHB2 CA2 21441934 1955234 Regulation EPHB2 CA2 21441934 1955235 Regulation EPHB2 CA2 21441934 1955236 Regulation EPHB2 CA2 21441934 1955237 Regulation EPHB2 CA2 21441934 1955244 Regulation EPHB2 CA2 21441934 1955245 Regulation EPHB2 CA2 21441934 1955250 Regulation EPHB2 CA2 21441934 1955256 Regulation EPHB2 CA2 21441934 1955257 Regulation EPHB2 CA2 21441934 1955261 Regulation EPHB2 CA2 21441934 1955264 Regulation EPHB2 CA2 21441934 1955269 Regulation EPHB2 CA2 21441934 1955284 Regulation EPHB2 CA2 21779236 933155 Regulation EPHB2 CA2 22412973 2609911 Regulation EPHB2 CA2 22904641 490789 Regulation EPHB2 CA2 24381634 825017 Regulation EPHB2 CA2 24687958 1575540 Regulation EPHB2 CA2 24687958 1575553 Regulation EPHB2 CA2 24897022 1127373 Regulation EPHB2 CA2 25121483 2997211 Regulation EPHB2 CALM3 17505539 1054768 Regulation EPHB2 CALM3 20071468 1772997 Regulation EPHB2 CALM3 21092323 1657410 Regulation EPHB2 CALM3 22904641 490790 Regulation EPHB2 CALM3 24381634 825018 Regulation EPHB2 CAMK1 20859543 3208978 Regulation EPHB2 CAMK4 20859543 3208979 Regulation EPHB2 CAMK4 24839356 1758690 Regulation EPHB2 CAPN1 24394804 1940217 Regulation EPHB2 CAPN10 24394804 1940218 Regulation EPHB2 CAPN11 24394804 1940219 Regulation EPHB2 CAPN12 24394804 1940216 Regulation EPHB2 CAPN13 24394804 1940228 Regulation EPHB2 CAPN14 24394804 1940229 Regulation EPHB2 CAPN15 24394804 1940215 Regulation EPHB2 CAPN2 24394804 1940220 Regulation EPHB2 CAPN3 24394804 1940221 Regulation EPHB2 CAPN5 24394804 1940222 Regulation EPHB2 CAPN6 24394804 1940223 Regulation EPHB2 CAPN7 24394804 1940224 Regulation EPHB2 CAPN8 24394804 1940225 Regulation EPHB2 CAPN9 24394804 1940226 Regulation EPHB2 CASP1 23685957 17731 Regulation EPHB2 CASP10 23685957 17732 Regulation EPHB2 CASP12 23685957 17742 Regulation EPHB2 CASP14 23685957 17733 Regulation EPHB2 CASP16 23685957 17743 Regulation EPHB2 CASP2 23685957 17734 Regulation EPHB2 CASP3 23685957 17735 Regulation EPHB2 CASP4 23685957 17736 Regulation EPHB2 CASP5 23685957 17737 Regulation EPHB2 CASP6 23685957 17738 Regulation EPHB2 CASP7 23685957 17739 Regulation EPHB2 CASP8 23685957 17740 Regulation EPHB2 CASP9 23685957 17741 Regulation EPHB2 CASR 23439762 1714768 Regulation EPHB2 CAST 24394804 1940227 Regulation EPHB2 CAV1 17893196 1547079 Regulation EPHB2 CAV1 24119769 1700727 Regulation EPHB2 CAV1 24917393 1234151 Regulation EPHB2 CAV1 25313138 2205110 Regulation EPHB2 CAV2 24917393 1234152 Regulation EPHB2 CAV3 24917393 1234153 Regulation EPHB2 CBR1 19476641 1897218 Regulation EPHB2 CBX4 22870894 802981 Regulation EPHB2 CCL20 21949768 2556469 Regulation EPHB2 CCM2 19151728 1960555 Regulation EPHB2 CCNA2 25187756 484816 Regulation EPHB2 CCNA2 25187756 484825 Regulation EPHB2 CCNA2 25187756 484851 Regulation EPHB2 CCND1 22833568 1806128 Regulation EPHB2 CCND1 22833568 1806129 Regulation EPHB2 CCND1 22833568 1806146 Regulation EPHB2 CD151 20581856 10209 Regulation EPHB2 CD151 20581856 10212 Regulation EPHB2 CD151 20581856 10215 Regulation EPHB2 CD2 18629305 793202 Regulation EPHB2 CD2 18629305 793203 Regulation EPHB2 CD2 18629305 793343 Regulation EPHB2 CD2 18629305 793368 Regulation EPHB2 CD2 18629305 793369 Regulation EPHB2 CD244 24687958 1575535 Regulation EPHB2 CD28 22912825 2679452 Regulation EPHB2 CD36 23487416 925936 Regulation EPHB2 CD46 24465142 842029 Regulation EPHB2 CD79A 19897477 1167297 Regulation EPHB2 CD79A 19897477 1167304 Regulation EPHB2 CD79A 21441934 1955258 Regulation EPHB2 CD79A 9763608 1604085 Regulation EPHB2 CD79B 19897477 1167298 Regulation EPHB2 CD79B 19897477 1167305 Regulation EPHB2 CD79B 21441934 1955259 Regulation EPHB2 CD79B 9763608 1604086 Regulation EPHB2 CDC42 21455314 2510244 Regulation EPHB2 CDC42 24352036 1632457 Regulation EPHB2 CDC73 21298035 2499467 Regulation EPHB2 CDC73 23911909 1637781 Regulation EPHB2 CDH1 22543706 14717 Regulation EPHB2 CDH2 20011526 2433442 Regulation EPHB2 CDK5 23840313 2812540 Regulation EPHB2 CDK5 23840313 2812560 Regulation EPHB2 CDKAL1 23840313 2812541 Regulation EPHB2 CDKN1A 23006971 2181121 Regulation EPHB2 CDKN1A 25196936 1730911 Regulation EPHB2 CHKA 21772273 1933155 Regulation EPHB2 CHKA 21772273 1933184 Regulation EPHB2 CHM 19480713 253502 Regulation EPHB2 CHUK 23752269 1905020 Regulation EPHB2 CHUK 23752269 1905032 Regulation EPHB2 CIB1 22964641 2148670 Regulation EPHB2 CLN3 24058789 1705741 Regulation EPHB2 CLN5 24058789 1705742 Regulation EPHB2 CLN6 24058789 1705743 Regulation EPHB2 CLN8 24058789 1705744 Regulation EPHB2 CLN9 24058789 1705745 Regulation EPHB2 CNP 23883591 128902 Regulation EPHB2 CPP 20740074 860367 Regulation EPHB2 CPSF3L 22131969 860792 Regulation EPHB2 CREB1 21441990 936221 Regulation EPHB2 CREB1 22817771 471870 Regulation EPHB2 CREB1 22927840 23040 Regulation EPHB2 CREB3 21441990 936222 Regulation EPHB2 CREB3 22927840 23041 Regulation EPHB2 CREB5 21441990 936220 Regulation EPHB2 CREB5 22927840 23039 Regulation EPHB2 CREG1 24018888 1112460 Regulation EPHB2 CRK 10477763 1249245 Regulation EPHB2 CRK 18648505 2393281 Regulation EPHB2 CRK 19426560 525606 Regulation EPHB2 CRK 19497102 1503763 Regulation EPHB2 CRK 20644716 2455977 Regulation EPHB2 CRK 22245064 613505 Regulation EPHB2 CROT 21107320 1986749 Regulation EPHB2 CRP 24594607 2929925 Regulation EPHB2 CSF1 10648566 1255385 Regulation EPHB2 CSF1 22028782 2564135 Regulation EPHB2 CSF1 22028782 2564136 Regulation EPHB2 CSF1 22028782 2564159 Regulation EPHB2 CSF1 22028782 2564195 Regulation EPHB2 CSF1 22028782 2564196 Regulation EPHB2 CSF1 22028782 2564213 Regulation EPHB2 CSF1 22028782 2564214 Regulation EPHB2 CSF1 22028782 2564233 Regulation EPHB2 CSF1 22028782 2564278 Regulation EPHB2 CSF1 23162740 589254 Regulation EPHB2 CSF1 25313137 2205097 Regulation EPHB2 CSPG4 21179491 2488397 Regulation EPHB2 CSPG5 21179491 2488398 Regulation EPHB2 CST3 19956729 2432662 Regulation EPHB2 CTNND1 10477763 1249246 Regulation EPHB2 CTNND1 18793427 281733 Regulation EPHB2 CTNND1 23261059 219931 Regulation EPHB2 CTNND1 23261059 219932 Regulation EPHB2 CTNND1 23261059 219933 Regulation EPHB2 CTR9 21298035 2499468 Regulation EPHB2 CTR9 23911909 1637782 Regulation EPHB2 CUL1 11435472 1519614 Regulation EPHB2 CUL1 11435472 1519634 Regulation EPHB2 CUL1 23420868 2085681 Regulation EPHB2 CX3CL1 19840952 513438 Regulation EPHB2 CX3CL1 19840952 513439 Regulation EPHB2 CX3CL1 19840952 513440 Regulation EPHB2 CXCL12 19106094 1165211 Regulation EPHB2 CXCL12 19106094 1165225 Regulation EPHB2 CXCL12 20376365 2445453 Regulation EPHB2 CXCL12 21364640 549723 Regulation EPHB2 CXCL12 22152016 469598 Regulation EPHB2 CXCL12 23308188 2738593 Regulation EPHB2 CXCL12 23308188 2738628 Regulation EPHB2 CXCL12 23308188 2738678 Regulation EPHB2 CXCL12 23308188 2738684 Regulation EPHB2 CXCL12 24629239 1872995 Regulation EPHB2 CXCL12 24629239 1872996 Regulation EPHB2 CXCL12 24629239 1873014 Regulation EPHB2 CXCL12 24629239 1873015 Regulation EPHB2 CXCL12 24629239 1873016 Regulation EPHB2 CXCR4 19106094 1165212 Regulation EPHB2 CXCR4 23308188 2738587 Regulation EPHB2 CXCR4 23308188 2738594 Regulation EPHB2 CXCR4 23308188 2738629 Regulation EPHB2 CXCR4 23308188 2738689 Regulation EPHB2 CXCR4 24629239 1872997 Regulation EPHB2 CXCR4 24629239 1873018 Regulation EPHB2 CYLD 17548520 1546313 Regulation EPHB2 CYLD 17548520 1546322 Regulation EPHB2 CYLD 23335970 2741152 Regulation EPHB2 DAG1 20163697 526489 Regulation EPHB2 DAG1 20163697 526493 Regulation EPHB2 DDX20 22348054 2596650 Regulation EPHB2 DFFB 21939503 1863432 Regulation EPHB2 DIRAS1 23667643 2790923 Regulation EPHB2 DLK1 20827342 2114922 Regulation EPHB2 DNLZ 12821648 1293282 Regulation EPHB2 DOCK1 10477763 1249322 Regulation EPHB2 DOK1 22514638 2619614 Regulation EPHB2 DOK3 22761938 2659378 Regulation EPHB2 DOK3 22761938 2659389 Regulation EPHB2 DOK3 22761938 2659404 Regulation EPHB2 DOK3 22761938 2659431 Regulation EPHB2 DOK3 22761938 2659435 Regulation EPHB2 DST 22991565 1498097 Regulation EPHB2 DTX1 23566222 1867758 Regulation EPHB2 DTX2 23566222 1867755 Regulation EPHB2 DTX3 23566222 1867756 Regulation EPHB2 DTX4 23566222 1867757 Regulation EPHB2 DUSP1 18650424 1164126 Regulation EPHB2 DUSP1 19476641 1897219 Regulation EPHB2 DUSP1 20226009 255623 Regulation EPHB2 DUSP1 21253577 3050643 Regulation EPHB2 DUSP1 21253577 3050748 Regulation EPHB2 DUSP1 22235371 1687027 Regulation EPHB2 DUSP1 24409315 2906865 Regulation EPHB2 DUSP10 18650424 1164127 Regulation EPHB2 DUSP10 21253577 3050644 Regulation EPHB2 DUSP11 18650424 1164128 Regulation EPHB2 DUSP11 21253577 3050645 Regulation EPHB2 DUSP12 18650424 1164129 Regulation EPHB2 DUSP12 21253577 3050646 Regulation EPHB2 DUSP13 18650424 1164121 Regulation EPHB2 DUSP13 21253577 3050638 Regulation EPHB2 DUSP14 18650424 1164117 Regulation EPHB2 DUSP14 21253577 3050634 Regulation EPHB2 DUSP15 18650424 1164116 Regulation EPHB2 DUSP15 21253577 3050633 Regulation EPHB2 DUSP16 18650424 1164118 Regulation EPHB2 DUSP16 20551953 435630 Regulation EPHB2 DUSP16 21253577 3050635 Regulation EPHB2 DUSP16 25019380 2988750 Regulation EPHB2 DUSP18 18650424 1164119 Regulation EPHB2 DUSP18 21253577 3050636 Regulation EPHB2 DUSP18 24847354 886089 Regulation EPHB2 DUSP19 18650424 1164120 Regulation EPHB2 DUSP19 21253577 3050637 Regulation EPHB2 DUSP2 18650424 1164130 Regulation EPHB2 DUSP2 21253577 3050647 Regulation EPHB2 DUSP2 23560086 2776909 Regulation EPHB2 DUSP2 23560086 2776916 Regulation EPHB2 DUSP2 25019380 2988751 Regulation EPHB2 DUSP21 18650424 1164122 Regulation EPHB2 DUSP21 21253577 3050639 Regulation EPHB2 DUSP22 18650424 1164115 Regulation EPHB2 DUSP22 21253577 3050632 Regulation EPHB2 DUSP23 18650424 1164123 Regulation EPHB2 DUSP23 21253577 3050640 Regulation EPHB2 DUSP26 18650424 1164125 Regulation EPHB2 DUSP26 21253577 3050642 Regulation EPHB2 DUSP27 18650424 1164124 Regulation EPHB2 DUSP27 21253577 3050641 Regulation EPHB2 DUSP28 18650424 1164138 Regulation EPHB2 DUSP28 21253577 3050655 Regulation EPHB2 DUSP3 18650424 1164131 Regulation EPHB2 DUSP3 21253577 3050648 Regulation EPHB2 DUSP4 18650424 1164132 Regulation EPHB2 DUSP4 21253577 3050649 Regulation EPHB2 DUSP4 25019380 2988752 Regulation EPHB2 DUSP5 18650424 1164133 Regulation EPHB2 DUSP5 21253577 3050650 Regulation EPHB2 DUSP6 18650424 1164134 Regulation EPHB2 DUSP6 19897477 1167253 Regulation EPHB2 DUSP6 19897477 1167299 Regulation EPHB2 DUSP6 19897477 1167313 Regulation EPHB2 DUSP6 21151572 2485166 Regulation EPHB2 DUSP6 21253577 3050651 Regulation EPHB2 DUSP7 18650424 1164135 Regulation EPHB2 DUSP7 21253577 3050652 Regulation EPHB2 DUSP8 18650424 1164136 Regulation EPHB2 DUSP8 21253577 3050653 Regulation EPHB2 DUSP9 18650424 1164137 Regulation EPHB2 DUSP9 21253577 3050654 Regulation EPHB2 DYNLRB1 23755307 2802598 Regulation EPHB2 EDN1 12734570 173167 Regulation EPHB2 EFNB1 23143520 1967862 Regulation EPHB2 EFNB2 23143520 1967863 Regulation EPHB2 EFNB3 23143520 1967864 Regulation EPHB2 EFNB3 23303128 558857 Regulation EPHB2 EGF 11897012 389904 Regulation EPHB2 EGF 12618892 422302 Regulation EPHB2 EGF 16301336 1325567 Regulation EPHB2 EGF 16301336 1325574 Regulation EPHB2 EGF 16365168 1326413 Regulation EPHB2 EGF 16914058 242028 Regulation EPHB2 EGF 17692468 157419 Regulation EPHB2 EGF 18004277 1902443 Regulation EPHB2 EGF 18158318 1548143 Regulation EPHB2 EGF 18335055 2387154 Regulation EPHB2 EGF 18662397 1242945 Regulation EPHB2 EGF 19036157 463304 Regulation EPHB2 EGF 19878579 283581 Regulation EPHB2 EGF 20122271 1853420 Regulation EPHB2 EGF 20688134 1880907 Regulation EPHB2 EGF 20700538 2458211 Regulation EPHB2 EGF 22245064 613498 Regulation EPHB2 EGF 22245064 613502 Regulation EPHB2 EGF 22245064 613503 Regulation EPHB2 EGF 22245064 613622 Regulation EPHB2 EGF 22701712 2652223 Regulation EPHB2 EGF 22920937 406777 Regulation EPHB2 EGF 22920937 406784 Regulation EPHB2 EGF 22920937 406786 Regulation EPHB2 EGF 23079107 409270 Regulation EPHB2 EGF 23133355 2297549 Regulation EPHB2 EGF 23162692 3131666 Regulation EPHB2 EGF 23800251 1627088 Regulation EPHB2 EGF 23800251 1627183 Regulation EPHB2 EGF 23800251 1627184 Regulation EPHB2 EGF 23800251 1627185 Regulation EPHB2 EGF 23800251 1627186 Regulation EPHB2 EGF 23990774 2298809 Regulation EPHB2 EGF 24069528 750739 Regulation EPHB2 EGF 24212795 498492 Regulation EPHB2 EGF 24744103 494921 Regulation EPHB2 EGF 24775912 1874095 Regulation EPHB2 EGF 24779681 1874154 Regulation EPHB2 EGF 24912820 273716 Regulation EPHB2 EGF 24916153 399791 Regulation EPHB2 EGF 25009466 869651 Regulation EPHB2 EGF 25258648 1240970 Regulation EPHB2 EGF PMC2750204 450242 Regulation EPHB2 EGFL7 24647208 2936076 Regulation EPHB2 EGFR 11897012 389905 Regulation EPHB2 EGFR 11897012 389906 Regulation EPHB2 EGFR 17449939 1634815 Regulation EPHB2 EGFR 19188434 707948 Regulation EPHB2 EGFR 19254952 1165602 Regulation EPHB2 EGFR 19840952 513483 Regulation EPHB2 EGFR 21092323 1657411 Regulation EPHB2 EGFR 21961726 261148 Regulation EPHB2 EGFR 22110740 2573139 Regulation EPHB2 EGFR 22294553 777879 Regulation EPHB2 EGFR 22294553 777880 Regulation EPHB2 EGFR 22675028 1803710 Regulation EPHB2 EGFR 22785133 1631028 Regulation EPHB2 EGFR 22904641 490791 Regulation EPHB2 EGFR 22967907 1506563 Regulation EPHB2 EGFR 22984397 2688304 Regulation EPHB2 EGFR 23272129 2729628 Regulation EPHB2 EGFR 23620784 2783448 Regulation EPHB2 EGFR 23829771 410479 Regulation EPHB2 EGFR 23911909 1637829 Regulation EPHB2 EGFR 23991110 2840954 Regulation EPHB2 EGFR 24136232 568213 Regulation EPHB2 EGFR 24351824 1122111 Regulation EPHB2 EGFR 24351824 1122112 Regulation EPHB2 EGFR 24552586 389094 Regulation EPHB2 EGFR 24552586 389098 Regulation EPHB2 EGFR 24552586 389101 Regulation EPHB2 EGFR 24721622 1679254 Regulation EPHB2 EGFR 25258648 1240971 Regulation EPHB2 EGFR 25421240 1135039 Regulation EPHB2 EGFR 25421240 1135170 Regulation EPHB2 EGFR 25606852 3038452 Regulation EPHB2 EGR1 21559295 2518075 Regulation EPHB2 EIF2AK2 23844083 2819263 Regulation EPHB2 EIF4E 24744726 973485 Regulation EPHB2 ELK1 14981092 1306523 Regulation EPHB2 ELK1 18334532 2033643 Regulation EPHB2 EML4 24715763 2249900 Regulation EPHB2 ENG 24489709 2916086 Regulation EPHB2 EPHA2 22570727 2631478 Regulation EPHB2 EPHA2 22916121 2680030 Regulation EPHB2 EPO 21860424 2142214 Regulation EPHB2 EPO 21860424 2142217 Regulation EPHB2 EPO 21860424 2142218 Regulation EPHB2 EPO 23028796 2693073 Regulation EPHB2 EPOR 21860424 2142220 Regulation EPHB2 ERBB2 20711231 2133604 Regulation EPHB2 ERBB2 20711231 2133645 Regulation EPHB2 ERBB2 20825649 1858636 Regulation EPHB2 ERBB2 21278786 2137756 Regulation EPHB2 ERBB2 23803171 536536 Regulation EPHB2 ERBB2 24374844 1681154 Regulation EPHB2 ERBB2 24551596 947319 Regulation EPHB2 ERBB2 24918976 620155 Regulation EPHB2 ERBB3 24551596 947320 Regulation EPHB2 ETS1 25294825 2105170 Regulation EPHB2 ETS1 25294825 2105190 Regulation EPHB2 ETS2 25294825 2105171 Regulation EPHB2 EXOSC3 23823806 2808842 Regulation EPHB2 F10 23066391 1076876 Regulation EPHB2 FAIM 15520226 1316197 Regulation EPHB2 FAIM2 23029562 2698764 Regulation EPHB2 FANCF 22952942 2685425 Regulation EPHB2 FAS 23552603 2156291 Regulation EPHB2 FAS 25068294 2992766 Regulation EPHB2 FASLG 22247744 639749 Regulation EPHB2 FBLIM1 22843679 1204099 Regulation EPHB2 FGF1 18625063 2000290 Regulation EPHB2 FGF1 18625063 2000572 Regulation EPHB2 FGF1 19333377 2409402 Regulation EPHB2 FGF1 19888221 433928 Regulation EPHB2 FGF1 24823357 1883816 Regulation EPHB2 FGF10 18625063 2000291 Regulation EPHB2 FGF10 18625063 2000573 Regulation EPHB2 FGF10 19333377 2409403 Regulation EPHB2 FGF10 19888221 433929 Regulation EPHB2 FGF11 18625063 2000292 Regulation EPHB2 FGF11 18625063 2000574 Regulation EPHB2 FGF11 19333377 2409404 Regulation EPHB2 FGF11 19888221 433930 Regulation EPHB2 FGF12 18625063 2000293 Regulation EPHB2 FGF12 18625063 2000575 Regulation EPHB2 FGF12 19333377 2409405 Regulation EPHB2 FGF12 19888221 433931 Regulation EPHB2 FGF13 18625063 2000294 Regulation EPHB2 FGF13 18625063 2000576 Regulation EPHB2 FGF13 19333377 2409406 Regulation EPHB2 FGF13 19888221 433932 Regulation EPHB2 FGF14 18625063 2000295 Regulation EPHB2 FGF14 18625063 2000577 Regulation EPHB2 FGF14 19333377 2409407 Regulation EPHB2 FGF14 19888221 433933 Regulation EPHB2 FGF16 18625063 2000296 Regulation EPHB2 FGF16 18625063 2000578 Regulation EPHB2 FGF16 19333377 2409408 Regulation EPHB2 FGF16 19888221 433934 Regulation EPHB2 FGF17 18625063 2000297 Regulation EPHB2 FGF17 18625063 2000579 Regulation EPHB2 FGF17 19333377 2409409 Regulation EPHB2 FGF17 19888221 433935 Regulation EPHB2 FGF18 18625063 2000298 Regulation EPHB2 FGF18 18625063 2000580 Regulation EPHB2 FGF18 19333377 2409410 Regulation EPHB2 FGF18 19888221 433936 Regulation EPHB2 FGF18 23863940 1990734 Regulation EPHB2 FGF19 18625063 2000299 Regulation EPHB2 FGF19 18625063 2000581 Regulation EPHB2 FGF19 19333377 2409411 Regulation EPHB2 FGF19 19888221 433937 Regulation EPHB2 FGF2 18625063 2000300 Regulation EPHB2 FGF2 18625063 2000582 Regulation EPHB2 FGF2 19333377 2409412 Regulation EPHB2 FGF2 19888221 433938 Regulation EPHB2 FGF2 20652960 3170721 Regulation EPHB2 FGF2 20652960 3170884 Regulation EPHB2 FGF2 21037797 2301680 Regulation EPHB2 FGF2 21037797 2301681 Regulation EPHB2 FGF2 21152424 2486335 Regulation EPHB2 FGF2 21224849 769119 Regulation EPHB2 FGF2 23864770 1754274 Regulation EPHB2 FGF20 18625063 2000301 Regulation EPHB2 FGF20 18625063 2000583 Regulation EPHB2 FGF20 19333377 2409413 Regulation EPHB2 FGF20 19888221 433939 Regulation EPHB2 FGF21 18625063 2000302 Regulation EPHB2 FGF21 18625063 2000584 Regulation EPHB2 FGF21 19333377 2409414 Regulation EPHB2 FGF21 19888221 433940 Regulation EPHB2 FGF22 18625063 2000303 Regulation EPHB2 FGF22 18625063 2000585 Regulation EPHB2 FGF22 19333377 2409415 Regulation EPHB2 FGF22 19888221 433941 Regulation EPHB2 FGF23 18625063 2000304 Regulation EPHB2 FGF23 18625063 2000586 Regulation EPHB2 FGF23 19333377 2409416 Regulation EPHB2 FGF23 19888221 433942 Regulation EPHB2 FGF23 21346724 1709683 Regulation EPHB2 FGF3 18625063 2000305 Regulation EPHB2 FGF3 18625063 2000587 Regulation EPHB2 FGF3 19333377 2409417 Regulation EPHB2 FGF3 19888221 433943 Regulation EPHB2 FGF4 18625063 2000306 Regulation EPHB2 FGF4 18625063 2000588 Regulation EPHB2 FGF4 19333377 2409418 Regulation EPHB2 FGF4 19888221 433944 Regulation EPHB2 FGF5 18625063 2000307 Regulation EPHB2 FGF5 18625063 2000589 Regulation EPHB2 FGF5 19333377 2409419 Regulation EPHB2 FGF5 19888221 433945 Regulation EPHB2 FGF6 18625063 2000308 Regulation EPHB2 FGF6 18625063 2000590 Regulation EPHB2 FGF6 19333377 2409420 Regulation EPHB2 FGF6 19888221 433946 Regulation EPHB2 FGF7 18625063 2000309 Regulation EPHB2 FGF7 18625063 2000591 Regulation EPHB2 FGF7 19333377 2409421 Regulation EPHB2 FGF7 19888221 433947 Regulation EPHB2 FGF7 21152424 2486336 Regulation EPHB2 FGF7 21224849 769120 Regulation EPHB2 FGF8 18625063 2000310 Regulation EPHB2 FGF8 18625063 2000592 Regulation EPHB2 FGF8 19333377 2409422 Regulation EPHB2 FGF8 19888221 433948 Regulation EPHB2 FGF9 18625063 2000311 Regulation EPHB2 FGF9 18625063 2000593 Regulation EPHB2 FGF9 19333377 2409423 Regulation EPHB2 FGF9 19888221 433949 Regulation EPHB2 FGFR1 19047466 1361997 Regulation EPHB2 FGFR1 19047466 1361998 Regulation EPHB2 FGFR1 19047466 1361999 Regulation EPHB2 FGFR1 19047466 1362063 Regulation EPHB2 FGFR1 19047466 1362064 Regulation EPHB2 FGFR1 19047466 1362144 Regulation EPHB2 FGFR1 22348054 2596651 Regulation EPHB2 FGFR2 19047466 1362000 Regulation EPHB2 FGFR2 19047466 1362001 Regulation EPHB2 FGFR2 19047466 1362145 Regulation EPHB2 FGFR2 22247000 777687 Regulation EPHB2 FGFR3 19047466 1362002 Regulation EPHB2 FGFR3 19047466 1362003 Regulation EPHB2 FGFR3 19047466 1362146 Regulation EPHB2 FGFR3 22369073 651495 Regulation EPHB2 FGFR4 19047466 1362004 Regulation EPHB2 FGFR4 19047466 1362005 Regulation EPHB2 FGFR4 19047466 1362147 Regulation EPHB2 FHIT 23947369 537308 Regulation EPHB2 FIGF 19812696 2428027 Regulation EPHB2 FLT3 21048955 2480106 Regulation EPHB2 FLT3 21048955 2480137 Regulation EPHB2 FLT3LG 21422499 2175736 Regulation EPHB2 FN1 19930650 526312 Regulation EPHB2 FN1 9832564 1472235 Regulation EPHB2 FOS 23551430 1480170 Regulation EPHB2 FOS 24465697 2911461 Regulation EPHB2 FOSL1 24658684 2937895 Regulation EPHB2 FOXM1 23285101 2732530 Regulation EPHB2 FOXO1 20375467 27014 Regulation EPHB2 FOXO3 20375467 27015 Regulation EPHB2 FOXO4 20375467 27016 Regulation EPHB2 FOXO6 20375467 27013 Regulation EPHB2 FPR1 24192910 1920120 Regulation EPHB2 FRS2 20652960 3170760 Regulation EPHB2 FRS2 22078327 262683 Regulation EPHB2 GAB1 12177047 1286340 Regulation EPHB2 GAB1 19357636 1902846 Regulation EPHB2 GAB2 16009726 1321418 Regulation EPHB2 GAB2 19737390 526032 Regulation EPHB2 GAB2 21996746 2143761 Regulation EPHB2 GABPA 25353254 1731134 Regulation EPHB2 GDF15 24597762 152539 Regulation EPHB2 GDNF 24603431 2357225 Regulation EPHB2 GEMIN2 22348054 2596644 Regulation EPHB2 GEMIN4 22348054 2596646 Regulation EPHB2 GEMIN5 22348054 2596647 Regulation EPHB2 GEMIN6 22348054 2596648 Regulation EPHB2 GEMIN7 22348054 2596649 Regulation EPHB2 GHR 23761784 878686 Regulation EPHB2 GHR 24963636 2983415 Regulation EPHB2 GHR 25301264 841043 Regulation EPHB2 GNAS 21731751 2532407 Regulation EPHB2 GNB1 21731751 2532408 Regulation EPHB2 GNB1 22447027 1956846 Regulation EPHB2 GNG2 21731751 2532409 Regulation EPHB2 GNG2 22447027 1956847 Regulation EPHB2 GNRH1 20507982 1188016 Regulation EPHB2 GNRH1 20507982 1188017 Regulation EPHB2 GNRH1 20507982 1188020 Regulation EPHB2 GNRH1 20507982 1188026 Regulation EPHB2 GNRH1 20507982 1188033 Regulation EPHB2 GNRH1 20507982 1188037 Regulation EPHB2 GNRH1 20507982 1188038 Regulation EPHB2 GNRH1 20688134 1880918 Regulation EPHB2 GNRH1 22235371 1687009 Regulation EPHB2 GNRH1 22235371 1687025 Regulation EPHB2 GNRH1 22235371 1687028 Regulation EPHB2 GNRH1 24482225 1208929 Regulation EPHB2 GPER1 23823806 2808843 Regulation EPHB2 GPER1 24379833 2120024 Regulation EPHB2 GPI 23785474 2806386 Regulation EPHB2 GPX3 25333265 2205626 Regulation EPHB2 GPX3 25333265 2205630 Regulation EPHB2 GRAP2 23977387 2840261 Regulation EPHB2 GRAP2 24991762 576770 Regulation EPHB2 GRB2 24775912 1874125 Regulation EPHB2 GRB7 23285101 2732531 Regulation EPHB2 GRIN2B 24391850 2904750 Regulation EPHB2 GRIN2B 24391850 2904755 Regulation EPHB2 GRK5 24597858 1650582 Regulation EPHB2 GRK6 24597858 1650583 Regulation EPHB2 GSTM1 22867088 2233271 Regulation EPHB2 HBEGF 22110740 2573129 Regulation EPHB2 HDAC1 23166712 2718727 Regulation EPHB2 HDAC1 23249388 341560 Regulation EPHB2 HDAC2 23166712 2718728 Regulation EPHB2 HDAC2 23249388 341561 Regulation EPHB2 HGF 18820214 706893 Regulation EPHB2 HGF 24223799 2877076 Regulation EPHB2 HGF 24517345 3163323 Regulation EPHB2 HGF 24840640 1087365 Regulation EPHB2 HGF 25383712 3024281 Regulation EPHB2 HMBS 16079071 792378 Regulation EPHB2 HMGB1 17923528 1345115 Regulation EPHB2 HMGB1 20799933 120036 Regulation EPHB2 HMGB1 24710477 618475 Regulation EPHB2 HNRNPF 25111504 2996288 Regulation EPHB2 HNRNPH1 25111504 2996289 Regulation EPHB2 HPSE 22773906 1914636 Regulation EPHB2 HRAS 12516548 2001324 Regulation EPHB2 HRAS 17449939 1634816 Regulation EPHB2 HRAS 18335053 2386991 Regulation EPHB2 HRAS 18629230 1212678 Regulation EPHB2 HRAS 19319189 2408586 Regulation EPHB2 HRAS 19861649 505912 Regulation EPHB2 HRAS 20071468 1772974 Regulation EPHB2 HRAS 20176802 1557437 Regulation EPHB2 HRAS 20562914 2132759 Regulation EPHB2 HRAS 20663127 386342 Regulation EPHB2 HRAS 20733035 1559917 Regulation EPHB2 HRAS 21042537 2479655 Regulation EPHB2 HRAS 21317450 2175056 Regulation EPHB2 HRAS 21731751 2532426 Regulation EPHB2 HRAS 21831290 1505428 Regulation EPHB2 HRAS 21833779 3327 Regulation EPHB2 HRAS 22363839 1687338 Regulation EPHB2 HRAS 22384111 2605927 Regulation EPHB2 HRAS 23076254 604972 Regulation EPHB2 HRAS 23758320 151570 Regulation EPHB2 HRAS 23758320 151585 Regulation EPHB2 HRAS 23758320 151645 Regulation EPHB2 HRAS 23802073 2162522 Regulation EPHB2 HRAS 25514808 3034997 Regulation EPHB2 HRG 19878579 283582 Regulation EPHB2 HRG 24551596 947321 Regulation EPHB2 HSPG2 22235275 2585726 Regulation EPHB2 HSPG2 22904641 490792 Regulation EPHB2 HTR2B 19956756 2432679 Regulation EPHB2 IARS 22035226 527810 Regulation EPHB2 IARS 22662132 2647046 Regulation EPHB2 ID1 18489764 352172 Regulation EPHB2 IFIT2 20565770 360381 Regulation EPHB2 IGF1 16365168 1326416 Regulation EPHB2 IGF1 18958173 2399565 Regulation EPHB2 IGF1 19834495 546423 Regulation EPHB2 IGF1 21127754 2120738 Regulation EPHB2 IGF1 21595894 467791 Regulation EPHB2 IGF1 22159423 1140656 Regulation EPHB2 IGF1 22419908 951412 Regulation EPHB2 IGF1 22536447 2622519 Regulation EPHB2 IGF1 24779681 1874142 Regulation EPHB2 IGF1R 23823800 1108159 Regulation EPHB2 IGF2 17988375 300882 Regulation EPHB2 IGF2 25089899 2994740 Regulation EPHB2 IGFBP3 25601855 881533 Regulation EPHB2 IGKV1-12 21860608 1038258 Regulation EPHB2 IKBKB 23752269 1905021 Regulation EPHB2 IKBKB 23752269 1905033 Regulation EPHB2 IKBKG 23752269 1905022 Regulation EPHB2 IKBKG 23752269 1905034 Regulation EPHB2 IL10 19667062 1555754 Regulation EPHB2 IL10 24260222 2882912 Regulation EPHB2 IL10 24260222 2882913 Regulation EPHB2 IL10 24260222 2882950 Regulation EPHB2 IL12A 22537317 355886 Regulation EPHB2 IL12B 22537317 355887 Regulation EPHB2 IL17A 22171994 1864447 Regulation EPHB2 IL17A 23202271 1958371 Regulation EPHB2 IL1A 10648566 1255397 Regulation EPHB2 IL1A 16207331 104362 Regulation EPHB2 IL1A 16504015 278983 Regulation EPHB2 IL1A 20799933 120049 Regulation EPHB2 IL1A 23883591 128903 Regulation EPHB2 IL1A PMC2833918 134430 Regulation EPHB2 IL2 22769588 521319 Regulation EPHB2 IL21 24574581 1757526 Regulation EPHB2 IL24 23772146 1636138 Regulation EPHB2 IL3 21706055 2140579 Regulation EPHB2 IL33 23418608 2754884 Regulation EPHB2 IL4 22761864 2658897 Regulation EPHB2 IL6 19267906 1655667 Regulation EPHB2 IL8 23034049 3113204 Regulation EPHB2 ILK 11696562 1276072 Regulation EPHB2 INS 14568990 1299552 Regulation EPHB2 INS 14568990 1299561 Regulation EPHB2 INS 14568990 1299563 Regulation EPHB2 INS 16951716 810679 Regulation EPHB2 INS 19357636 1902903 Regulation EPHB2 INS 21044348 1891780 Regulation EPHB2 INS 22111877 334685 Regulation EPHB2 INS 22111877 334787 Regulation EPHB2 INS 22206009 2584142 Regulation EPHB2 INS 24276258 2244584 Regulation EPHB2 INS 24348809 843969 Regulation EPHB2 INS 24423625 1727666 Regulation EPHB2 INS 24632852 2934396 Regulation EPHB2 INS 24632852 2934405 Regulation EPHB2 INTS1 22131969 860786 Regulation EPHB2 INTS10 22131969 860789 Regulation EPHB2 INTS12 22131969 860788 Regulation EPHB2 INTS2 22131969 860794 Regulation EPHB2 INTS3 22131969 860793 Regulation EPHB2 INTS4 22131969 860787 Regulation EPHB2 INTS5 22131969 860795 Regulation EPHB2 INTS6 22131969 860784 Regulation EPHB2 INTS7 22131969 860785 Regulation EPHB2 INTS8 22131969 860791 Regulation EPHB2 INTS9 22131969 860790 Regulation EPHB2 IQSEC1 22701712 2652212 Regulation EPHB2 IRAK4 21396111 527130 Regulation EPHB2 ITCH 24708812 1843045 Regulation EPHB2 ITGA5 24971065 965300 Regulation EPHB2 ITGAM 24603876 2932595 Regulation EPHB2 ITIH4 20835359 2220387 Regulation EPHB2 ITSN1 20824214 2474040 Regulation EPHB2 ITSN2 20824214 2474041 Regulation EPHB2 JAK1 20388118 147706 Regulation EPHB2 JAK1 20388118 147737 Regulation EPHB2 JAK2 19066310 707376 Regulation EPHB2 JAK2 19066310 707377 Regulation EPHB2 JAK2 20388118 147707 Regulation EPHB2 JAK2 20388118 147738 Regulation EPHB2 JAK3 20388118 147708 Regulation EPHB2 JAK3 20388118 147739 Regulation EPHB2 JMJD1C 24348429 972612 Regulation EPHB2 JUN 16172258 1537785 Regulation EPHB2 JUN 19144997 1991910 Regulation EPHB2 JUN 25294825 2105172 Regulation EPHB2 KHDRBS1 14736338 277385 Regulation EPHB2 KIDINS220 23999075 2235862 Regulation EPHB2 KISS1R 20886089 2476250 Regulation EPHB2 KISS1R 20886089 2476251 Regulation EPHB2 KISS1R 20886089 2476252 Regulation EPHB2 KISS1R 20886089 2476274 Regulation EPHB2 KISS1R 20886089 2476275 Regulation EPHB2 KITLG 11435472 1519561 Regulation EPHB2 KITLG 22216034 22208 Regulation EPHB2 KRAS 12516548 2001325 Regulation EPHB2 KRAS 17449939 1634817 Regulation EPHB2 KRAS 18335053 2386992 Regulation EPHB2 KRAS 18629230 1212679 Regulation EPHB2 KRAS 19861649 505913 Regulation EPHB2 KRAS 20071468 1772975 Regulation EPHB2 KRAS 20176802 1557438 Regulation EPHB2 KRAS 20562914 2132760 Regulation EPHB2 KRAS 20663127 386343 Regulation EPHB2 KRAS 20733035 1559918 Regulation EPHB2 KRAS 21042537 2479656 Regulation EPHB2 KRAS 21317450 2175057 Regulation EPHB2 KRAS 21831290 1505429 Regulation EPHB2 KRAS 21833779 3328 Regulation EPHB2 KRAS 22363839 1687339 Regulation EPHB2 KRAS 22384111 2605928 Regulation EPHB2 KRAS 22472349 1698251 Regulation EPHB2 KRAS 23076254 604973 Regulation EPHB2 KRAS 23758320 151571 Regulation EPHB2 KRAS 23758320 151586 Regulation EPHB2 KRAS 23758320 151646 Regulation EPHB2 KRAS 23802073 2162523 Regulation EPHB2 KRAS 24071646 566642 Regulation EPHB2 KRAS 25514808 3034998 Regulation EPHB2 KSR1 17971232 1646110 Regulation EPHB2 KSR1 21829671 2542261 Regulation EPHB2 KSR1 21829671 2542262 Regulation EPHB2 KSR1 21829671 2542266 Regulation EPHB2 KSR1 21829671 2542284 Regulation EPHB2 KSR1 21829671 2542294 Regulation EPHB2 KSR1 21829671 2542299 Regulation EPHB2 KSR1 24209692 517670 Regulation EPHB2 KSR2 24209692 517632 Regulation EPHB2 KSR2 24918056 853928 Regulation EPHB2 LAMTOR3 21829671 2542259 Regulation EPHB2 LAMTOR3 21829671 2542260 Regulation EPHB2 LAMTOR3 21829671 2542264 Regulation EPHB2 LAMTOR3 21829671 2542265 Regulation EPHB2 LAMTOR3 21829671 2542283 Regulation EPHB2 LAMTOR3 21829671 2542293 Regulation EPHB2 LCK 23758320 151560 Regulation EPHB2 LCK 23758320 151572 Regulation EPHB2 LCK 23758320 151573 Regulation EPHB2 LCK 24172637 3123968 Regulation EPHB2 LCK PMC3236909 3125412 Regulation EPHB2 LEO1 21298035 2499471 Regulation EPHB2 LEO1 23911909 1637785 Regulation EPHB2 LEP 19066310 707378 Regulation EPHB2 LEP 19066310 707379 Regulation EPHB2 LEP 19066310 707395 Regulation EPHB2 LEP 20870968 729641 Regulation EPHB2 LEP 21286276 667767 Regulation EPHB2 LEP 22690216 1674017 Regulation EPHB2 LGALS1 22237208 553922 Regulation EPHB2 LGI1 23713523 138559 Regulation EPHB2 LIF 19267906 1655668 Regulation EPHB2 LIN37 23908058 3227904 Regulation EPHB2 LIN52 23908058 3227901 Regulation EPHB2 LIN54 23908058 3227902 Regulation EPHB2 LIN9 23908058 3227903 Regulation EPHB2 LPA 21209852 2491416 Regulation EPHB2 LPA 22639801 212815 Regulation EPHB2 LPA 22639801 212818 Regulation EPHB2 LPA 23209312 1570354 Regulation EPHB2 LPA 23726972 1054182 Regulation EPHB2 LPA 24928086 273918 Regulation EPHB2 LRIG2 24023893 2844094 Regulation EPHB2 LRP1 12499359 1290489 Regulation EPHB2 LRP1 20644732 2456036 Regulation EPHB2 LRP1 20644732 2456075 Regulation EPHB2 LRP1 20644732 2456076 Regulation EPHB2 LRP1 20644732 2456132 Regulation EPHB2 LRP1 20644732 2456154 Regulation EPHB2 LRP5 20011526 2433443 Regulation EPHB2 LTB 24842369 1576282 Regulation EPHB2 LTB4R2 23799854 440991 Regulation EPHB2 LYN 22731636 1866179 Regulation EPHB2 MALT1 23586039 181016 Regulation EPHB2 MALT1 23586039 181189 Regulation EPHB2 MAP1LC3A 24240988 1939495 Regulation EPHB2 MAP2 17984326 1346313 Regulation EPHB2 MAP2K1 10508858 1250917 Regulation EPHB2 MAP2K1 11257120 1267955 Regulation EPHB2 MAP2K1 11435472 1519590 Regulation EPHB2 MAP2K1 12370087 225138 Regulation EPHB2 MAP2K1 14981092 1306524 Regulation EPHB2 MAP2K1 14997206 424362 Regulation EPHB2 MAP2K1 15353548 1311973 Regulation EPHB2 MAP2K1 16172258 1537786 Regulation EPHB2 MAP2K1 16278666 426785 Regulation EPHB2 MAP2K1 18053155 1896968 Regulation EPHB2 MAP2K1 19165201 431722 Regulation EPHB2 MAP2K1 19182807 1952237 Regulation EPHB2 MAP2K1 19390590 2415333 Regulation EPHB2 MAP2K1 19878579 283646 Regulation EPHB2 MAP2K1 20868520 1859538 Regulation EPHB2 MAP2K1 21505228 2175922 Regulation EPHB2 MAP2K1 21559502 2520079 Regulation EPHB2 MAP2K1 21860067 2176448 Regulation EPHB2 MAP2K1 21886829 2547825 Regulation EPHB2 MAP2K1 21952000 1898519 Regulation EPHB2 MAP2K1 22448169 3075841 Regulation EPHB2 MAP2K1 22577355 2296716 Regulation EPHB2 MAP2K1 22808290 2665567 Regulation EPHB2 MAP2K1 23237773 2182007 Regulation EPHB2 MAP2K1 23658559 883848 Regulation EPHB2 MAP2K1 24023871 2843875 Regulation EPHB2 MAP2K1 24550252 752946 Regulation EPHB2 MAP2K1 24597858 1650565 Regulation EPHB2 MAP2K1 24687958 1575536 Regulation EPHB2 MAP2K1 24687958 1575541 Regulation EPHB2 MAP2K1 24921927 2372769 Regulation EPHB2 MAP2K1 25187756 484826 Regulation EPHB2 MAP2K1 25514788 3034691 Regulation EPHB2 MAP2K2 11257120 1267956 Regulation EPHB2 MAP2K2 11435472 1519591 Regulation EPHB2 MAP2K2 12370087 225139 Regulation EPHB2 MAP2K2 14981092 1306525 Regulation EPHB2 MAP2K2 16172258 1537787 Regulation EPHB2 MAP2K2 16278666 426786 Regulation EPHB2 MAP2K2 18053155 1896969 Regulation EPHB2 MAP2K2 19165201 431723 Regulation EPHB2 MAP2K2 19390590 2415334 Regulation EPHB2 MAP2K2 19878579 283647 Regulation EPHB2 MAP2K2 20868520 1859539 Regulation EPHB2 MAP2K2 21505228 2175923 Regulation EPHB2 MAP2K2 21559502 2520080 Regulation EPHB2 MAP2K2 21860067 2176449 Regulation EPHB2 MAP2K2 21886829 2547826 Regulation EPHB2 MAP2K2 21952000 1898520 Regulation EPHB2 MAP2K2 22448169 3075842 Regulation EPHB2 MAP2K2 22577355 2296717 Regulation EPHB2 MAP2K2 23237773 2182008 Regulation EPHB2 MAP2K2 23658559 883849 Regulation EPHB2 MAP2K2 24023871 2843876 Regulation EPHB2 MAP2K2 24550252 752947 Regulation EPHB2 MAP2K2 24597858 1650566 Regulation EPHB2 MAP2K2 24921927 2372770 Regulation EPHB2 MAP2K2 25187756 484827 Regulation EPHB2 MAP2K2 25514788 3034692 Regulation EPHB2 MAP2K3 11257120 1267957 Regulation EPHB2 MAP2K3 11435472 1519592 Regulation EPHB2 MAP2K3 12370087 225140 Regulation EPHB2 MAP2K3 14981092 1306526 Regulation EPHB2 MAP2K3 16172258 1537788 Regulation EPHB2 MAP2K3 16278666 426787 Regulation EPHB2 MAP2K3 18053155 1896970 Regulation EPHB2 MAP2K3 19165201 431724 Regulation EPHB2 MAP2K3 19390590 2415335 Regulation EPHB2 MAP2K3 19878579 283648 Regulation EPHB2 MAP2K3 20868520 1859540 Regulation EPHB2 MAP2K3 21505228 2175924 Regulation EPHB2 MAP2K3 21559502 2520081 Regulation EPHB2 MAP2K3 21860067 2176450 Regulation EPHB2 MAP2K3 21886829 2547827 Regulation EPHB2 MAP2K3 22448169 3075843 Regulation EPHB2 MAP2K3 22577355 2296718 Regulation EPHB2 MAP2K3 23237773 2182009 Regulation EPHB2 MAP2K3 23658559 883850 Regulation EPHB2 MAP2K3 24023871 2843877 Regulation EPHB2 MAP2K3 24550252 752948 Regulation EPHB2 MAP2K3 24597858 1650567 Regulation EPHB2 MAP2K3 24921927 2372771 Regulation EPHB2 MAP2K3 25187756 484828 Regulation EPHB2 MAP2K3 25514788 3034693 Regulation EPHB2 MAP2K4 11257120 1267958 Regulation EPHB2 MAP2K4 11435472 1519593 Regulation EPHB2 MAP2K4 12370087 225141 Regulation EPHB2 MAP2K4 14981092 1306527 Regulation EPHB2 MAP2K4 16172258 1537789 Regulation EPHB2 MAP2K4 16278666 426788 Regulation EPHB2 MAP2K4 18053155 1896971 Regulation EPHB2 MAP2K4 19165201 431725 Regulation EPHB2 MAP2K4 19390590 2415336 Regulation EPHB2 MAP2K4 19878579 283649 Regulation EPHB2 MAP2K4 20868520 1859541 Regulation EPHB2 MAP2K4 21505228 2175925 Regulation EPHB2 MAP2K4 21559502 2520082 Regulation EPHB2 MAP2K4 21860067 2176451 Regulation EPHB2 MAP2K4 21886829 2547828 Regulation EPHB2 MAP2K4 22448169 3075844 Regulation EPHB2 MAP2K4 22577355 2296719 Regulation EPHB2 MAP2K4 23237773 2182010 Regulation EPHB2 MAP2K4 23658559 883851 Regulation EPHB2 MAP2K4 24023871 2843878 Regulation EPHB2 MAP2K4 24550252 752949 Regulation EPHB2 MAP2K4 24597858 1650568 Regulation EPHB2 MAP2K4 24921927 2372772 Regulation EPHB2 MAP2K4 25187756 484829 Regulation EPHB2 MAP2K4 25514788 3034694 Regulation EPHB2 MAP2K5 11257120 1267959 Regulation EPHB2 MAP2K5 11435472 1519594 Regulation EPHB2 MAP2K5 12370087 225142 Regulation EPHB2 MAP2K5 14981092 1306528 Regulation EPHB2 MAP2K5 16172258 1537790 Regulation EPHB2 MAP2K5 16278666 426789 Regulation EPHB2 MAP2K5 18053155 1896972 Regulation EPHB2 MAP2K5 19165201 431726 Regulation EPHB2 MAP2K5 19390590 2415337 Regulation EPHB2 MAP2K5 19878579 283650 Regulation EPHB2 MAP2K5 20868520 1859542 Regulation EPHB2 MAP2K5 21505228 2175926 Regulation EPHB2 MAP2K5 21559502 2520083 Regulation EPHB2 MAP2K5 21860067 2176452 Regulation EPHB2 MAP2K5 21886829 2547829 Regulation EPHB2 MAP2K5 22448169 3075845 Regulation EPHB2 MAP2K5 22577355 2296720 Regulation EPHB2 MAP2K5 23237773 2182011 Regulation EPHB2 MAP2K5 23658559 883852 Regulation EPHB2 MAP2K5 24023871 2843879 Regulation EPHB2 MAP2K5 24550252 752950 Regulation EPHB2 MAP2K5 24597858 1650569 Regulation EPHB2 MAP2K5 24921927 2372773 Regulation EPHB2 MAP2K5 25187756 484830 Regulation EPHB2 MAP2K5 25514788 3034695 Regulation EPHB2 MAP2K6 11257120 1267960 Regulation EPHB2 MAP2K6 11435472 1519595 Regulation EPHB2 MAP2K6 12370087 225143 Regulation EPHB2 MAP2K6 14981092 1306529 Regulation EPHB2 MAP2K6 16172258 1537791 Regulation EPHB2 MAP2K6 16278666 426790 Regulation EPHB2 MAP2K6 18053155 1896973 Regulation EPHB2 MAP2K6 19165201 431727 Regulation EPHB2 MAP2K6 19390590 2415338 Regulation EPHB2 MAP2K6 19878579 283651 Regulation EPHB2 MAP2K6 20868520 1859543 Regulation EPHB2 MAP2K6 21505228 2175927 Regulation EPHB2 MAP2K6 21559502 2520084 Regulation EPHB2 MAP2K6 21860067 2176453 Regulation EPHB2 MAP2K6 21886829 2547830 Regulation EPHB2 MAP2K6 22448169 3075846 Regulation EPHB2 MAP2K6 22577355 2296721 Regulation EPHB2 MAP2K6 23237773 2182012 Regulation EPHB2 MAP2K6 23658559 883853 Regulation EPHB2 MAP2K6 24023871 2843880 Regulation EPHB2 MAP2K6 24550252 752951 Regulation EPHB2 MAP2K6 24597858 1650570 Regulation EPHB2 MAP2K6 24921927 2372774 Regulation EPHB2 MAP2K6 25187756 484831 Regulation EPHB2 MAP2K6 25514788 3034696 Regulation EPHB2 MAP2K7 11257120 1267961 Regulation EPHB2 MAP2K7 11435472 1519596 Regulation EPHB2 MAP2K7 12370087 225144 Regulation EPHB2 MAP2K7 14981092 1306530 Regulation EPHB2 MAP2K7 16172258 1537792 Regulation EPHB2 MAP2K7 16278666 426791 Regulation EPHB2 MAP2K7 18053155 1896974 Regulation EPHB2 MAP2K7 19165201 431728 Regulation EPHB2 MAP2K7 19390590 2415339 Regulation EPHB2 MAP2K7 19878579 283652 Regulation EPHB2 MAP2K7 20868520 1859544 Regulation EPHB2 MAP2K7 21505228 2175928 Regulation EPHB2 MAP2K7 21559502 2520085 Regulation EPHB2 MAP2K7 21860067 2176454 Regulation EPHB2 MAP2K7 21886829 2547831 Regulation EPHB2 MAP2K7 22448169 3075847 Regulation EPHB2 MAP2K7 22577355 2296722 Regulation EPHB2 MAP2K7 23237773 2182013 Regulation EPHB2 MAP2K7 23658559 883854 Regulation EPHB2 MAP2K7 24023871 2843881 Regulation EPHB2 MAP2K7 24550252 752952 Regulation EPHB2 MAP2K7 24597858 1650571 Regulation EPHB2 MAP2K7 24921927 2372775 Regulation EPHB2 MAP2K7 25187756 484832 Regulation EPHB2 MAP2K7 25514788 3034697 Regulation EPHB2 MAP3K1 18420486 705505 Regulation EPHB2 MAP3K1 18420486 705507 Regulation EPHB2 MAP3K13 23552557 2156005 Regulation EPHB2 MAP3K13 23552557 2156006 Regulation EPHB2 MAP3K13 23552557 2156136 Regulation EPHB2 MAP3K3 24206648 367427 Regulation EPHB2 MAP3K7 24801688 2961698 Regulation EPHB2 MAP3K8 19667062 1555639 Regulation EPHB2 MAP3K8 19808894 711287 Regulation EPHB2 MAP4K1 11514608 1520615 Regulation EPHB2 MAPK1 16172258 1537793 Regulation EPHB2 MAPK1 18648505 2393283 Regulation EPHB2 MAPK1 21559189 1052556 Regulation EPHB2 MAPK1 21559368 2518965 Regulation EPHB2 MAPK1 22182854 1720441 Regulation EPHB2 MAPK1 23977387 2840262 Regulation EPHB2 MAPK1 24423080 538840 Regulation EPHB2 MAPK1 25258648 1240916 Regulation EPHB2 MAPK10 16172258 1537794 Regulation EPHB2 MAPK10 18648505 2393284 Regulation EPHB2 MAPK10 21559368 2518966 Regulation EPHB2 MAPK10 22182854 1720442 Regulation EPHB2 MAPK10 23977387 2840263 Regulation EPHB2 MAPK10 24423080 538841 Regulation EPHB2 MAPK10 25258648 1240917 Regulation EPHB2 MAPK11 16172258 1537795 Regulation EPHB2 MAPK11 18648505 2393285 Regulation EPHB2 MAPK11 21559368 2518967 Regulation EPHB2 MAPK11 22182854 1720443 Regulation EPHB2 MAPK11 23977387 2840264 Regulation EPHB2 MAPK11 24423080 538842 Regulation EPHB2 MAPK11 25258648 1240918 Regulation EPHB2 MAPK12 16172258 1537796 Regulation EPHB2 MAPK12 18648505 2393286 Regulation EPHB2 MAPK12 21559368 2518968 Regulation EPHB2 MAPK12 22182854 1720444 Regulation EPHB2 MAPK12 23977387 2840265 Regulation EPHB2 MAPK12 24423080 538843 Regulation EPHB2 MAPK12 25258648 1240919 Regulation EPHB2 MAPK13 16172258 1537797 Regulation EPHB2 MAPK13 18648505 2393287 Regulation EPHB2 MAPK13 21559368 2518969 Regulation EPHB2 MAPK13 22182854 1720445 Regulation EPHB2 MAPK13 23977387 2840266 Regulation EPHB2 MAPK13 24423080 538844 Regulation EPHB2 MAPK13 25258648 1240920 Regulation EPHB2 MAPK14 16172258 1537798 Regulation EPHB2 MAPK14 18648505 2393288 Regulation EPHB2 MAPK14 21559368 2518970 Regulation EPHB2 MAPK14 22182854 1720446 Regulation EPHB2 MAPK14 23977387 2840267 Regulation EPHB2 MAPK14 24423080 538845 Regulation EPHB2 MAPK14 25258648 1240921 Regulation EPHB2 MAPK15 16172258 1537784 Regulation EPHB2 MAPK15 18648505 2393282 Regulation EPHB2 MAPK15 21559368 2518964 Regulation EPHB2 MAPK15 22182854 1720440 Regulation EPHB2 MAPK15 23977387 2840260 Regulation EPHB2 MAPK15 24423080 538839 Regulation EPHB2 MAPK15 25258648 1240915 Regulation EPHB2 MAPK3 16172258 1537799 Regulation EPHB2 MAPK3 18648505 2393289 Regulation EPHB2 MAPK3 21559368 2518971 Regulation EPHB2 MAPK3 22182854 1720447 Regulation EPHB2 MAPK3 23977387 2840268 Regulation EPHB2 MAPK3 24423080 538846 Regulation EPHB2 MAPK3 25258648 1240922 Regulation EPHB2 MAPK4 16172258 1537800 Regulation EPHB2 MAPK4 18648505 2393290 Regulation EPHB2 MAPK4 21559368 2518972 Regulation EPHB2 MAPK4 22182854 1720448 Regulation EPHB2 MAPK4 23977387 2840269 Regulation EPHB2 MAPK4 24423080 538847 Regulation EPHB2 MAPK4 25258648 1240923 Regulation EPHB2 MAPK6 16172258 1537801 Regulation EPHB2 MAPK6 18648505 2393291 Regulation EPHB2 MAPK6 21559368 2518973 Regulation EPHB2 MAPK6 22182854 1720449 Regulation EPHB2 MAPK6 23977387 2840270 Regulation EPHB2 MAPK6 24423080 538848 Regulation EPHB2 MAPK6 25258648 1240924 Regulation EPHB2 MAPK7 16172258 1537802 Regulation EPHB2 MAPK7 18648505 2393292 Regulation EPHB2 MAPK7 21559368 2518974 Regulation EPHB2 MAPK7 22182854 1720450 Regulation EPHB2 MAPK7 23977387 2840271 Regulation EPHB2 MAPK7 24423080 538849 Regulation EPHB2 MAPK7 25258648 1240925 Regulation EPHB2 MAPK8 16172258 1537803 Regulation EPHB2 MAPK8 18648505 2393293 Regulation EPHB2 MAPK8 21559368 2518975 Regulation EPHB2 MAPK8 22182854 1720451 Regulation EPHB2 MAPK8 23977387 2840272 Regulation EPHB2 MAPK8 24423080 538850 Regulation EPHB2 MAPK8 25258648 1240926 Regulation EPHB2 MAPK9 16172258 1537804 Regulation EPHB2 MAPK9 18648505 2393294 Regulation EPHB2 MAPK9 21559368 2518976 Regulation EPHB2 MAPK9 22182854 1720452 Regulation EPHB2 MAPK9 23977387 2840273 Regulation EPHB2 MAPK9 24423080 538851 Regulation EPHB2 MAPK9 25258648 1240927 Regulation EPHB2 MAPKAPK2 19343194 2290488 Regulation EPHB2 MAPKAPK3 22870894 802957 Regulation EPHB2 MARK2 22206009 2584146 Regulation EPHB2 MATK 21772273 1933156 Regulation EPHB2 MATK 21772273 1933157 Regulation EPHB2 MATK 21772273 1933168 Regulation EPHB2 MATK 21772273 1933177 Regulation EPHB2 MBTPS1 21887342 2549359 Regulation EPHB2 MCAM 24756564 3082112 Regulation EPHB2 MCHR1 23351214 628195 Regulation EPHB2 MED25 21253548 1673068 Regulation EPHB2 MIF 21283538 2495606 Regulation EPHB2 MITF 25045707 195103 Regulation EPHB2 MLST8 22668349 212893 Regulation EPHB2 MLST8 23437362 2756654 Regulation EPHB2 MLST8 24312679 2890624 Regulation EPHB2 MMP1 24928086 273951 Regulation EPHB2 MMP10 24928086 273952 Regulation EPHB2 MMP11 24928086 273953 Regulation EPHB2 MMP12 24928086 273954 Regulation EPHB2 MMP13 24928086 273955 Regulation EPHB2 MMP14 24928086 273956 Regulation EPHB2 MMP15 24928086 273957 Regulation EPHB2 MMP16 24928086 273958 Regulation EPHB2 MMP17 24928086 273959 Regulation EPHB2 MMP19 24928086 273960 Regulation EPHB2 MMP2 24928086 273961 Regulation EPHB2 MMP20 24928086 273962 Regulation EPHB2 MMP21 24928086 273949 Regulation EPHB2 MMP24 24928086 273963 Regulation EPHB2 MMP25 24928086 273946 Regulation EPHB2 MMP26 24928086 273947 Regulation EPHB2 MMP27 24928086 273948 Regulation EPHB2 MMP28 24928086 273950 Regulation EPHB2 MMP3 24928086 273964 Regulation EPHB2 MMP7 24928086 273965 Regulation EPHB2 MMP8 24928086 273966 Regulation EPHB2 MMP9 24928086 273967 Regulation EPHB2 MRE11A 18335053 2386993 Regulation EPHB2 MRXS5 19684611 8005 Regulation EPHB2 MSLN 23694968 3135814 Regulation EPHB2 MSTN 21048967 2480257 Regulation EPHB2 MTOR 20472883 2007924 Regulation EPHB2 MTOR 22668349 212898 Regulation EPHB2 MTOR 22851969 1674139 Regulation EPHB2 MTOR 23437362 2756575 Regulation EPHB2 MTOR 23437362 2756657 Regulation EPHB2 MTOR 24312679 2890626 Regulation EPHB2 MTOR 24391850 2904758 Regulation EPHB2 MTX1 22545735 313562 Regulation EPHB2 MUC16 23694968 3135817 Regulation EPHB2 MXD1 16880791 427900 Regulation EPHB2 MYD88 20300608 3046494 Regulation EPHB2 MYD88 20473309 1961045 Regulation EPHB2 MYEF2 20419100 2446954 Regulation EPHB2 MYLIP 22802911 2219414 Regulation EPHB2 MYLIP 23409140 2753798 Regulation EPHB2 MYLIP 23469214 2763234 Regulation EPHB2 MYLIP 23469214 2763240 Regulation EPHB2 MYLIP 23469214 2763280 Regulation EPHB2 MYLIP 23874686 2822015 Regulation EPHB2 MYLIP 23874686 2822016 Regulation EPHB2 MYLIP 24009080 2184719 Regulation EPHB2 MYLIP 24009080 2184726 Regulation EPHB2 MYLIP 25058496 2360930 Regulation EPHB2 MYLIP 25275294 2202546 Regulation EPHB2 MYLIP 25275294 2202603 Regulation EPHB2 MYLIP 25355277 1087853 Regulation EPHB2 MYLIP 25396727 3026978 Regulation EPHB2 MYLK 24255721 2882083 Regulation EPHB2 NA 18629305 793223 Regulation EPHB2 NA 18629305 793385 Regulation EPHB2 NA 21209852 2491460 Regulation EPHB2 NA 22867088 2233242 Regulation EPHB2 NA 23577223 2225776 Regulation EPHB2 NCOA3 23388133 267741 Regulation EPHB2 NCSTN 19247475 2406539 Regulation EPHB2 NEDD9 21829474 2541163 Regulation EPHB2 NELFCD 22238675 2586948 Regulation EPHB2 NELFCD 22238675 2586993 Regulation EPHB2 NF1 24278035 2353142 Regulation EPHB2 NF2 20163697 526484 Regulation EPHB2 NFKB1 23762330 2803046 Regulation EPHB2 NGF 20376360 2445407 Regulation EPHB2 NGF 20376360 2445429 Regulation EPHB2 NGF 22384148 2606911 Regulation EPHB2 NGF 22384148 2606998 Regulation EPHB2 NGF 24040018 2845235 Regulation EPHB2 NGF 24270184 1968743 Regulation EPHB2 NGF 25191523 588142 Regulation EPHB2 NLRP6 22763455 1988839 Regulation EPHB2 NLRP6 22763455 1988841 Regulation EPHB2 NOS1 19343212 3043672 Regulation EPHB2 NOTCH1 23908058 3227905 Regulation EPHB2 NOTCH2 23908058 3227906 Regulation EPHB2 NOTCH3 23908058 3227907 Regulation EPHB2 NOTCH4 23908058 3227908 Regulation EPHB2 NOX1 19804648 1835336 Regulation EPHB2 NOX1 24192910 1920121 Regulation EPHB2 NOX3 19804648 1835337 Regulation EPHB2 NOX4 19804648 1835338 Regulation EPHB2 NOX5 19804648 1835335 Regulation EPHB2 NPB 25093335 2995199 Regulation EPHB2 NPS 24624962 1921230 Regulation EPHB2 NPY4R 11897012 389907 Regulation EPHB2 NPY4R 23359326 2744885 Regulation EPHB2 NPY6R 22182854 1720453 Regulation EPHB2 NQO1 24505400 2920800 Regulation EPHB2 NRAS 12516548 2001326 Regulation EPHB2 NRAS 17449939 1634818 Regulation EPHB2 NRAS 18335053 2386994 Regulation EPHB2 NRAS 18629230 1212680 Regulation EPHB2 NRAS 19707310 175356 Regulation EPHB2 NRAS 19861649 505914 Regulation EPHB2 NRAS 20071468 1772976 Regulation EPHB2 NRAS 20176802 1557439 Regulation EPHB2 NRAS 20562914 2132761 Regulation EPHB2 NRAS 20663127 386344 Regulation EPHB2 NRAS 20733035 1559919 Regulation EPHB2 NRAS 21042537 2479657 Regulation EPHB2 NRAS 21317450 2175058 Regulation EPHB2 NRAS 21831290 1505430 Regulation EPHB2 NRAS 21833779 3329 Regulation EPHB2 NRAS 22363839 1687340 Regulation EPHB2 NRAS 22384111 2605929 Regulation EPHB2 NRAS 23076254 604974 Regulation EPHB2 NRAS 23758320 151574 Regulation EPHB2 NRAS 23758320 151587 Regulation EPHB2 NRAS 23758320 151647 Regulation EPHB2 NRAS 23802073 2162524 Regulation EPHB2 NRAS 25514808 3034999 Regulation EPHB2 NTN4 24265816 2885231 Regulation EPHB2 NTRK1 22384148 2606912 Regulation EPHB2 NTRK2 20156366 255304 Regulation EPHB2 NTRK2 21849472 1793460 Regulation EPHB2 NTS 21961726 261206 Regulation EPHB2 NTS 21961726 261207 Regulation EPHB2 NTS 21961726 261288 Regulation EPHB2 P2RX7 18553155 3089961 Regulation EPHB2 P2RY1 18404494 3089154 Regulation EPHB2 P2RY12 18404483 3088108 Regulation EPHB2 PAF1 21298035 2499469 Regulation EPHB2 PAF1 23911909 1637783 Regulation EPHB2 PAK1 20711231 2133722 Regulation EPHB2 PAK1 22096607 2571984 Regulation EPHB2 PAK1 23162742 589318 Regulation EPHB2 PAK2 20711231 2133723 Regulation EPHB2 PAK2 22096607 2571985 Regulation EPHB2 PAK2 23162742 589319 Regulation EPHB2 PAK3 20711231 2133724 Regulation EPHB2 PAK3 22096607 2571986 Regulation EPHB2 PAK3 23162742 589320 Regulation EPHB2 PAK4 20711231 2133720 Regulation EPHB2 PAK4 22096607 2571982 Regulation EPHB2 PAK4 23162742 589316 Regulation EPHB2 PAK6 20711231 2133721 Regulation EPHB2 PAK6 22096607 2571983 Regulation EPHB2 PAK6 23162742 589317 Regulation EPHB2 PAK7 20711231 2133719 Regulation EPHB2 PAK7 22096607 2571981 Regulation EPHB2 PAK7 23162742 589315 Regulation EPHB2 PARP1 18335053 2386989 Regulation EPHB2 PARP1 20824066 2473572 Regulation EPHB2 PARP1 24350055 946659 Regulation EPHB2 PARP1 24586933 2928425 Regulation EPHB2 PAX6 18507827 301425 Regulation EPHB2 PCSK1 21853090 2543180 Regulation EPHB2 PCSK1 21853090 2543203 Regulation EPHB2 PCSK1 21853090 2543206 Regulation EPHB2 PCSK1 21853090 2543210 Regulation EPHB2 PDE6D 20979602 3111541 Regulation EPHB2 PDGFB 17591920 1341665 Regulation EPHB2 PDGFRA 24489888 2916677 Regulation EPHB2 PEA15 19917132 385841 Regulation EPHB2 PEA15 22105357 2144465 Regulation EPHB2 PEA15 24717932 1023941 Regulation EPHB2 PEBP1 22860010 2670760 Regulation EPHB2 PER1 23243430 816454 Regulation EPHB2 PGC 17987121 2380290 Regulation EPHB2 PGC 17987121 2380294 Regulation EPHB2 PGC 19142226 2404353 Regulation EPHB2 PHC1 22870894 802982 Regulation EPHB2 PHLDA1 18597688 251141 Regulation EPHB2 PHLDA1 18597688 251146 Regulation EPHB2 PI3 11435472 1519562 Regulation EPHB2 PI3 12556972 422161 Regulation EPHB2 PI3 15149544 241448 Regulation EPHB2 PI3 18004277 1902487 Regulation EPHB2 PI3 18091994 2381410 Regulation EPHB2 PI3 21961726 261326 Regulation EPHB2 PI3 23320105 2739640 Regulation EPHB2 PI3 23320105 2739651 Regulation EPHB2 PIK3CA 16103225 1323257 Regulation EPHB2 PIK3CA 18091994 2381408 Regulation EPHB2 PIK3CA 20472883 2007925 Regulation EPHB2 PIK3CA 21209852 2491397 Regulation EPHB2 PIK3CA 22035226 527811 Regulation EPHB2 PIK3CA 22438844 951438 Regulation EPHB2 PIK3CA 22475322 264509 Regulation EPHB2 PIK3CA 22668349 212899 Regulation EPHB2 PIK3CA 22745786 2656474 Regulation EPHB2 PIK3CA 22812497 292284 Regulation EPHB2 PIK3CA 23308188 2738685 Regulation EPHB2 PIK3CA 23437362 2756705 Regulation EPHB2 PIK3CA 23986484 1487113 Regulation EPHB2 PIK3CA 23986484 1487114 Regulation EPHB2 PIK3CA 24222847 627841 Regulation EPHB2 PIK3CA 24710148 986050 Regulation EPHB2 PIK3CA 24743024 2189200 Regulation EPHB2 PIK3CA 25421240 1135040 Regulation EPHB2 PIK3R1 16103225 1323258 Regulation EPHB2 PIK3R1 18091994 2381409 Regulation EPHB2 PIK3R1 20472883 2007926 Regulation EPHB2 PIK3R1 21209852 2491398 Regulation EPHB2 PIK3R1 22035226 527812 Regulation EPHB2 PIK3R1 22438844 951439 Regulation EPHB2 PIK3R1 22475322 264510 Regulation EPHB2 PIK3R1 22668349 212900 Regulation EPHB2 PIK3R1 22745786 2656475 Regulation EPHB2 PIK3R1 22812497 292285 Regulation EPHB2 PIK3R1 23308188 2738686 Regulation EPHB2 PIK3R1 23437362 2756706 Regulation EPHB2 PIK3R1 23986484 1487115 Regulation EPHB2 PIK3R1 23986484 1487116 Regulation EPHB2 PIK3R1 24222847 627842 Regulation EPHB2 PIK3R1 24710148 986051 Regulation EPHB2 PIK3R1 24743024 2189201 Regulation EPHB2 PIK3R1 25421240 1135041 Regulation EPHB2 PIM1 19687226 1555820 Regulation EPHB2 PIM1 21860423 2142197 Regulation EPHB2 PLA2G1B 18312689 1003651 Regulation EPHB2 PLA2G4A 22911431 3058911 Regulation EPHB2 PLAU 12865932 422960 Regulation EPHB2 PLAU 12865932 422963 Regulation EPHB2 PLAUR 10508858 1250915 Regulation EPHB2 PLAUR 15798771 425454 Regulation EPHB2 PLAUR 16504015 278984 Regulation EPHB2 PLAUR 16504015 278985 Regulation EPHB2 PLAUR 21283769 2498250 Regulation EPHB2 PLAUR 21798065 1505386 Regulation EPHB2 PLAUR 21998707 2562090 Regulation EPHB2 PLAUR 22139533 3177812 Regulation EPHB2 PLD1 20231899 2443198 Regulation EPHB2 PLD1 20231899 2443454 Regulation EPHB2 PLD1 20231899 2443476 Regulation EPHB2 PLD1 22105357 2144466 Regulation EPHB2 PLD1 23989060 839596 Regulation EPHB2 PLD2 20231899 2443199 Regulation EPHB2 PLD2 20231899 2443455 Regulation EPHB2 PLD2 23989060 839597 Regulation EPHB2 PLD3 20231899 2443194 Regulation EPHB2 PLD3 20231899 2443450 Regulation EPHB2 PLD3 23989060 839592 Regulation EPHB2 PLD4 20231899 2443195 Regulation EPHB2 PLD4 20231899 2443451 Regulation EPHB2 PLD4 23989060 839593 Regulation EPHB2 PLD5 20231899 2443196 Regulation EPHB2 PLD5 20231899 2443452 Regulation EPHB2 PLD5 23989060 839594 Regulation EPHB2 PLD6 20231899 2443197 Regulation EPHB2 PLD6 20231899 2443453 Regulation EPHB2 PLD6 23989060 839595 Regulation EPHB2 PMAIP1 21253548 1673070 Regulation EPHB2 PNLIP 25610476 827655 Regulation EPHB2 PNLIP 25610476 827656 Regulation EPHB2 POLA2 21253548 1673069 Regulation EPHB2 POT1 23758320 151557 Regulation EPHB2 POT1 25629002 949894 Regulation EPHB2 POU2F1 24717932 1023910 Regulation EPHB2 POU2F1 24717932 1023911 Regulation EPHB2 POU2F1 24717932 1023912 Regulation EPHB2 POU2F1 24717932 1023932 Regulation EPHB2 POU2F1 24717932 1023938 Regulation EPHB2 POU5F1 24643025 2935536 Regulation EPHB2 PPM1A 22384250 2607585 Regulation EPHB2 PPM1A 23903585 3136542 Regulation EPHB2 PPP1R1B 22028687 860514 Regulation EPHB2 PPP1R3A 24558305 1615233 Regulation EPHB2 PPP2CA 19602257 385589 Regulation EPHB2 PPP2CA 19602257 385602 Regulation EPHB2 PPP2CA 23640330 2087548 Regulation EPHB2 PPP2CA 23704935 2796654 Regulation EPHB2 PPP2CA 24885237 1233653 Regulation EPHB2 PPP2CA 24885237 1233659 Regulation EPHB2 PPP2R1A 19602257 385590 Regulation EPHB2 PPP2R1A 19602257 385603 Regulation EPHB2 PPP2R1A 23640330 2087549 Regulation EPHB2 PPP2R1A 23704935 2796655 Regulation EPHB2 PPP2R1A 24885237 1233654 Regulation EPHB2 PPP2R1A 24885237 1233660 Regulation EPHB2 PPP2R2B 19602257 385591 Regulation EPHB2 PPP2R2B 19602257 385604 Regulation EPHB2 PPP2R2B 23640330 2087550 Regulation EPHB2 PPP2R2B 23704935 2796656 Regulation EPHB2 PPP2R2B 24885237 1233655 Regulation EPHB2 PPP2R2B 24885237 1233661 Regulation EPHB2 PRDM14 23670199 786267 Regulation EPHB2 PRDX1 23601194 536021 Regulation EPHB2 PRDX2 23951179 2833642 Regulation EPHB2 PRKAA1 22269797 1898982 Regulation EPHB2 PRKAA1 22751115 2147853 Regulation EPHB2 PRKAA1 22751115 2147863 Regulation EPHB2 PRKAA1 22751115 2147875 Regulation EPHB2 PRKAA1 24419232 506355 Regulation EPHB2 PRKAA2 22269797 1898983 Regulation EPHB2 PRKAA2 22751115 2147854 Regulation EPHB2 PRKAA2 22751115 2147864 Regulation EPHB2 PRKAA2 22751115 2147876 Regulation EPHB2 PRKAA2 24419232 506356 Regulation EPHB2 PRKAB1 22269797 1898984 Regulation EPHB2 PRKAB1 22751115 2147855 Regulation EPHB2 PRKAB1 22751115 2147865 Regulation EPHB2 PRKAB1 22751115 2147877 Regulation EPHB2 PRKAB1 24419232 506357 Regulation EPHB2 PRKAB2 22269797 1898985 Regulation EPHB2 PRKAB2 22751115 2147856 Regulation EPHB2 PRKAB2 22751115 2147866 Regulation EPHB2 PRKAB2 22751115 2147878 Regulation EPHB2 PRKAB2 24419232 506358 Regulation EPHB2 PRKACB 16091148 524525 Regulation EPHB2 PRKACB 19558693 253706 Regulation EPHB2 PRKACB 21695205 2529754 Regulation EPHB2 PRKACB 22645447 3153401 Regulation EPHB2 PRKACB 22927932 2681066 Regulation EPHB2 PRKACB 23667597 2790745 Regulation EPHB2 PRKACB 24098703 2858340 Regulation EPHB2 PRKACB 24409147 953573 Regulation EPHB2 PRKACB 25352775 939278 Regulation EPHB2 PRKACB 25629002 949897 Regulation EPHB2 PRKACG 16091148 524526 Regulation EPHB2 PRKACG 19558693 253707 Regulation EPHB2 PRKACG 21695205 2529755 Regulation EPHB2 PRKACG 22645447 3153402 Regulation EPHB2 PRKACG 22927932 2681067 Regulation EPHB2 PRKACG 23667597 2790746 Regulation EPHB2 PRKACG 24098703 2858341 Regulation EPHB2 PRKACG 24409147 953574 Regulation EPHB2 PRKACG 25352775 939279 Regulation EPHB2 PRKACG 25629002 949898 Regulation EPHB2 PRKAG1 22269797 1898986 Regulation EPHB2 PRKAG1 22751115 2147857 Regulation EPHB2 PRKAG1 22751115 2147867 Regulation EPHB2 PRKAG1 22751115 2147879 Regulation EPHB2 PRKAG1 24419232 506359 Regulation EPHB2 PRKAG2 22269797 1898987 Regulation EPHB2 PRKAG2 22751115 2147858 Regulation EPHB2 PRKAG2 22751115 2147868 Regulation EPHB2 PRKAG2 22751115 2147880 Regulation EPHB2 PRKAG2 24419232 506360 Regulation EPHB2 PRKAR1A 16091148 524527 Regulation EPHB2 PRKAR1A 19558693 253708 Regulation EPHB2 PRKAR1A 21695205 2529756 Regulation EPHB2 PRKAR1A 22645447 3153403 Regulation EPHB2 PRKAR1A 22927932 2681068 Regulation EPHB2 PRKAR1A 23667597 2790747 Regulation EPHB2 PRKAR1A 24098703 2858342 Regulation EPHB2 PRKAR1A 24409147 953575 Regulation EPHB2 PRKAR1A 25352775 939280 Regulation EPHB2 PRKAR1A 25629002 949899 Regulation EPHB2 PRKAR1B 16091148 524528 Regulation EPHB2 PRKAR1B 19558693 253709 Regulation EPHB2 PRKAR1B 21695205 2529757 Regulation EPHB2 PRKAR1B 22645447 3153404 Regulation EPHB2 PRKAR1B 22927932 2681069 Regulation EPHB2 PRKAR1B 23667597 2790748 Regulation EPHB2 PRKAR1B 24098703 2858343 Regulation EPHB2 PRKAR1B 24409147 953576 Regulation EPHB2 PRKAR1B 25352775 939281 Regulation EPHB2 PRKAR1B 25629002 949900 Regulation EPHB2 PRKAR2A 16091148 524529 Regulation EPHB2 PRKAR2A 19558693 253710 Regulation EPHB2 PRKAR2A 21695205 2529758 Regulation EPHB2 PRKAR2A 22645447 3153405 Regulation EPHB2 PRKAR2A 22927932 2681070 Regulation EPHB2 PRKAR2A 23667597 2790749 Regulation EPHB2 PRKAR2A 24098703 2858344 Regulation EPHB2 PRKAR2A 24409147 953577 Regulation EPHB2 PRKAR2A 25352775 939282 Regulation EPHB2 PRKAR2A 25629002 949901 Regulation EPHB2 PRKAR2B 16091148 524530 Regulation EPHB2 PRKAR2B 19558693 253711 Regulation EPHB2 PRKAR2B 21695205 2529759 Regulation EPHB2 PRKAR2B 22645447 3153406 Regulation EPHB2 PRKAR2B 22927932 2681071 Regulation EPHB2 PRKAR2B 23667597 2790750 Regulation EPHB2 PRKAR2B 24098703 2858345 Regulation EPHB2 PRKAR2B 24409147 953578 Regulation EPHB2 PRKAR2B 25352775 939283 Regulation EPHB2 PRKAR2B 25629002 949902 Regulation EPHB2 PRKCA PMC2377328 2003638 Regulation EPHB2 PRKCDBP 24069528 750680 Regulation EPHB2 PRKCDBP 25520561 487826 Regulation EPHB2 PRLR 23775766 727516 Regulation EPHB2 PSEN1 19247475 2406542 Regulation EPHB2 PSENEN 19247475 2406541 Regulation EPHB2 PSMG1 24098484 2856607 Regulation EPHB2 PTAFR 24721622 1679255 Regulation EPHB2 PTBP1 25111504 2996290 Regulation EPHB2 PTBP2 25111504 2996287 Regulation EPHB2 PTEN 25301264 841042 Regulation EPHB2 PTEN 9832564 1472223 Regulation EPHB2 PTEN 9832564 1472254 Regulation EPHB2 PTH 20578167 1237698 Regulation EPHB2 PTK2 9864370 1473412 Regulation EPHB2 PTPN11 11136824 1518294 Regulation EPHB2 PTPN11 19290061 2408110 Regulation EPHB2 PTPN11 22216034 22209 Regulation EPHB2 PTPN11 22777356 2148000 Regulation EPHB2 PTPN11 23189174 2722304 Regulation EPHB2 PTPN11 24628801 400942 Regulation EPHB2 PTPN11 25296975 2204268 Regulation EPHB2 PTPN11 25331952 1211124 Regulation EPHB2 PTPN13 19734941 2126781 Regulation EPHB2 PTPN22 23991106 2840938 Regulation EPHB2 PTPN3 24847354 886085 Regulation EPHB2 PTPN6 19144997 1991911 Regulation EPHB2 PTPN7 23761790 907704 Regulation EPHB2 PTPRF 19047466 1362163 Regulation EPHB2 PTPRK 20098592 1728770 Regulation EPHB2 PTPRR 17224080 1645039 Regulation EPHB2 PTPRR 17224080 1645040 Regulation EPHB2 PTPRR 17224080 1645041 Regulation EPHB2 PTS 24955212 2229186 Regulation EPHB2 PTX3 11897012 389919 Regulation EPHB2 PTX3 12821648 1293215 Regulation EPHB2 PTX3 18404491 3088327 Regulation EPHB2 PTX4 11897012 389918 Regulation EPHB2 PTX4 12821648 1293214 Regulation EPHB2 PTX4 18404491 3088326 Regulation EPHB2 PXN 22028449 788598 Regulation EPHB2 PXN 22970259 2687876 Regulation EPHB2 RAC1 11980921 1282365 Regulation EPHB2 RAC1 20711231 2133725 Regulation EPHB2 RAC1 22511753 1203209 Regulation EPHB2 RAC1 22970259 2687866 Regulation EPHB2 RAC1 23006971 2181122 Regulation EPHB2 RAC1 24040362 2846975 Regulation EPHB2 RAC2 11435472 1519563 Regulation EPHB2 RAC2 11581314 1521020 Regulation EPHB2 RAC2 11980921 1282366 Regulation EPHB2 RAC2 20711231 2133726 Regulation EPHB2 RAC2 22511753 1203210 Regulation EPHB2 RAC2 23006971 2181123 Regulation EPHB2 RAC3 11980921 1282367 Regulation EPHB2 RAC3 20711231 2133727 Regulation EPHB2 RAC3 22511753 1203211 Regulation EPHB2 RAC3 23006971 2181124 Regulation EPHB2 RAD1 24991762 576693 Regulation EPHB2 RAD17 24991762 576694 Regulation EPHB2 RAD18 24991762 576692 Regulation EPHB2 RAD21 24991762 576695 Regulation EPHB2 RAD50 18335053 2386995 Regulation EPHB2 RAD50 23758320 151561 Regulation EPHB2 RAD50 24991762 576696 Regulation EPHB2 RAD50 25629002 949903 Regulation EPHB2 RAD51 24991762 576697 Regulation EPHB2 RAD52 24991762 576698 Regulation EPHB2 RAF1 11157055 1518382 Regulation EPHB2 RAF1 11435472 1519597 Regulation EPHB2 RAF1 20562914 2132724 Regulation EPHB2 RAF1 20624904 1377616 Regulation EPHB2 RAF1 21860067 2176455 Regulation EPHB2 RAF1 22265677 1040510 Regulation EPHB2 RAF1 22384111 2605930 Regulation EPHB2 RAF1 22860010 2670761 Regulation EPHB2 RAF1 23758320 151648 Regulation EPHB2 RANBP9 23118896 2711972 Regulation EPHB2 RANBP9 23118896 2712032 Regulation EPHB2 RANBP9 23118896 2712038 Regulation EPHB2 RAPGEF1 17724123 1344175 Regulation EPHB2 RAPGEF2 17724123 1344174 Regulation EPHB2 RASA1 22761938 2659436 Regulation EPHB2 RASGRP1 17190838 1543862 Regulation EPHB2 RASGRP1 21441934 1955215 Regulation EPHB2 RASGRP1 22719950 2653889 Regulation EPHB2 RASGRP1 23308188 2738603 Regulation EPHB2 RASGRP1 24336796 752208 Regulation EPHB2 RASGRP1 25118589 1945212 Regulation EPHB2 RASGRP2 21441934 1955216 Regulation EPHB2 RASGRP2 25118589 1945213 Regulation EPHB2 RASGRP3 21441934 1955213 Regulation EPHB2 RASGRP3 22640752 126003 Regulation EPHB2 RASGRP3 24779681 1874140 Regulation EPHB2 RASGRP3 24779681 1874141 Regulation EPHB2 RASGRP3 24779681 1874153 Regulation EPHB2 RASGRP3 25118589 1945210 Regulation EPHB2 RASGRP4 17190838 1543951 Regulation EPHB2 RASGRP4 21441934 1955214 Regulation EPHB2 RASGRP4 25118589 1945211 Regulation EPHB2 RB1 23640330 2087551 Regulation EPHB2 RBBP4 23166712 2718729 Regulation EPHB2 RBBP4 23249388 341562 Regulation EPHB2 RBBP7 23166712 2718730 Regulation EPHB2 RBBP7 23249388 341563 Regulation EPHB2 RBL2 18793427 281734 Regulation EPHB2 REL 20562914 2132762 Regulation EPHB2 REL 23946691 1716145 Regulation EPHB2 RELA 23762330 2803047 Regulation EPHB2 RELN 23318582 610967 Regulation EPHB2 RGS2 24743392 2955371 Regulation EPHB2 RGS4 24743392 2955370 Regulation EPHB2 RHOA 18404483 3087996 Regulation EPHB2 RHOA 21731751 2532427 Regulation EPHB2 RICTOR 24130883 2867505 Regulation EPHB2 RING1 22870894 802980 Regulation EPHB2 RNF19A 23762330 2803045 Regulation EPHB2 RNF19A 24423080 538838 Regulation EPHB2 RPGR 24672654 1024324 Regulation EPHB2 RPTOR 22668349 212894 Regulation EPHB2 RPTOR 23437362 2756656 Regulation EPHB2 RPTOR 24130883 2867506 Regulation EPHB2 RPTOR 24312679 2890625 Regulation EPHB2 S100A8 19426560 525605 Regulation EPHB2 S100A8 22123830 1394007 Regulation EPHB2 S100A8 22312430 2595208 Regulation EPHB2 SAA1 25019380 2988748 Regulation EPHB2 SAA1 25019380 2988749 Regulation EPHB2 SAA1 25019380 2988767 Regulation EPHB2 SAA1 25019380 2988771 Regulation EPHB2 SAP18 23166712 2718724 Regulation EPHB2 SAP30 23166712 2718725 Regulation EPHB2 SCARNA5 23029099 2695236 Regulation EPHB2 SCRIB 23359326 2744883 Regulation EPHB2 SCRIB 23359326 2744884 Regulation EPHB2 SCRIB 23359326 2744893 Regulation EPHB2 SCRIB 23359326 2744903 Regulation EPHB2 SCRIB 23359326 2744939 Regulation EPHB2 SEC13 24797310 2189565 Regulation EPHB2 SEC62 24797310 2189566 Regulation EPHB2 SEC63 24797310 2189567 Regulation EPHB2 SETD2 21544242 2517486 Regulation EPHB2 SFN 23983046 135660 Regulation EPHB2 SH3GL2 21849472 1793446 Regulation EPHB2 SHC1 20624904 1377626 Regulation EPHB2 SHC1 22662132 2647045 Regulation EPHB2 SHOC2 25514808 3034811 Regulation EPHB2 SIN3A 23166712 2718726 Regulation EPHB2 SIRPA 21886829 2547823 Regulation EPHB2 SIRPA 21886829 2547832 Regulation EPHB2 SIRPA 21886829 2547834 Regulation EPHB2 SIRT1 18320031 2384855 Regulation EPHB2 SIRT1 24410795 1482587 Regulation EPHB2 SIRT1 24742694 2188981 Regulation EPHB2 SIX1 22765220 471718 Regulation EPHB2 SIX1 22765220 471719 Regulation EPHB2 SIX1 22765220 471737 Regulation EPHB2 SIX1 22945933 1399928 Regulation EPHB2 SKP1 11435472 1519612 Regulation EPHB2 SKP1 11435472 1519633 Regulation EPHB2 SKP1 23420868 2085679 Regulation EPHB2 SKP2 22279619 939658 Regulation EPHB2 SLC25A16 24130864 2867425 Regulation EPHB2 SLC2A4RG 20824214 2474039 Regulation EPHB2 SLC39A9 23505453 2766099 Regulation EPHB2 SLC4A3 24842369 1576348 Regulation EPHB2 SLC9A1 22904641 490794 Regulation EPHB2 SLC9A1 22904641 490802 Regulation EPHB2 SLC9A1 22904641 490804 Regulation EPHB2 SLC9A1 22904641 490811 Regulation EPHB2 SLC9A1 22904641 490815 Regulation EPHB2 SMAD1 22761782 2658386 Regulation EPHB2 SMAD2 22174924 2582567 Regulation EPHB2 SMAD7 24090133 537607 Regulation EPHB2 SMN2 22348054 2596645 Regulation EPHB2 SOAT1 20388118 147705 Regulation EPHB2 SOAT1 22649371 874882 Regulation EPHB2 SOCS3 24260222 2882911 Regulation EPHB2 SOCS3 PMC2833763 134316 Regulation EPHB2 SOS1 24027568 908809 Regulation EPHB2 SOS1 25397617 3027239 Regulation EPHB2 SOS2 24027568 908810 Regulation EPHB2 SOX2 24643025 2935535 Regulation EPHB2 SP1 21829524 2541584 Regulation EPHB2 SP1 23640330 2087546 Regulation EPHB2 SP3 24550717 2299699 Regulation EPHB2 SPP1 23935934 2828585 Regulation EPHB2 SPP1 23935934 2828592 Regulation EPHB2 SPP1 24810160 2189995 Regulation EPHB2 SPP1 24810160 2190002 Regulation EPHB2 SPRED1 24278701 3150194 Regulation EPHB2 SPRY1 23554919 2773978 Regulation EPHB2 SPRY2 24744103 494623 Regulation EPHB2 SPRY2 24744103 494842 Regulation EPHB2 SPRY4 22384148 2606910 Regulation EPHB2 SPRY4 23554919 2774070 Regulation EPHB2 SRC 11897012 389923 Regulation EPHB2 SRC 19568240 432396 Regulation EPHB2 SRC 19826415 2127392 Regulation EPHB2 SRC 20190765 1931141 Regulation EPHB2 SRC 21050441 257854 Regulation EPHB2 SRC 21152208 22754 Regulation EPHB2 SRC 21765460 2141051 Regulation EPHB2 SRC 21785723 1686378 Regulation EPHB2 SRC 22675459 2648693 Regulation EPHB2 SRC 23933651 18441 Regulation EPHB2 SRC 24751948 2956197 Regulation EPHB2 SRC 25396727 3026977 Regulation EPHB2 SRC 25566074 955124 Regulation EPHB2 SRC PMC3363182 391234 Regulation EPHB2 SRL 22315658 1702871 Regulation EPHB2 SST 23641235 878368 Regulation EPHB2 SST 24416361 2907962 Regulation EPHB2 SSTR2 22651821 1648797 Regulation EPHB2 SSTR3 22651821 1648798 Regulation EPHB2 ST5 23935508 2347825 Regulation EPHB2 STAB2 24586357 2924407 Regulation EPHB2 STAT3 12010564 98799 Regulation EPHB2 STAT3 22937006 2682712 Regulation EPHB2 STAT3 24260222 2882910 Regulation EPHB2 STAT3 24533454 271655 Regulation EPHB2 STYX 25479605 3032404 Regulation EPHB2 STYXL1 25019380 2988768 Regulation EPHB2 STYXL1 25019380 2988772 Regulation EPHB2 SYK 21687747 922416 Regulation EPHB2 SYK 21687806 922513 Regulation EPHB2 SYK 23424645 2755075 Regulation EPHB2 SYNGAP1 22558107 2624482 Regulation EPHB2 SYNGAP1 25426475 950176 Regulation EPHB2 TAB1 17205106 1054714 Regulation EPHB2 TAB1 17205106 1054716 Regulation EPHB2 TAB1 24801688 2961697 Regulation EPHB2 TAB2 23586039 181015 Regulation EPHB2 TAB2 23586039 181188 Regulation EPHB2 TACC3 24550739 2356978 Regulation EPHB2 TAT 18538010 356795 Regulation EPHB2 TERF1 23758320 151554 Regulation EPHB2 TERF1 25629002 949891 Regulation EPHB2 TERF2 18335053 2386986 Regulation EPHB2 TERF2 23758320 151555 Regulation EPHB2 TERF2 25629002 949892 Regulation EPHB2 TERF2IP 18335053 2386988 Regulation EPHB2 TERF2IP 23758320 151558 Regulation EPHB2 TERF2IP 25629002 949895 Regulation EPHB2 TET1 19255520 1703995 Regulation EPHB2 TET2 19255520 1703993 Regulation EPHB2 TET3 19255520 1703994 Regulation EPHB2 TFAP2A 19701232 8039 Regulation EPHB2 TGFB1 22111877 334684 Regulation EPHB2 THAP1 21961726 261197 Regulation EPHB2 THAP10 21961726 261204 Regulation EPHB2 THAP11 21961726 261205 Regulation EPHB2 THAP2 21961726 261195 Regulation EPHB2 THAP3 21961726 261196 Regulation EPHB2 THAP4 21961726 261198 Regulation EPHB2 THAP5 21961726 261199 Regulation EPHB2 THAP6 21961726 261200 Regulation EPHB2 THAP7 21961726 261201 Regulation EPHB2 THAP8 21961726 261202 Regulation EPHB2 THAP9 21961726 261203 Regulation EPHB2 THEMIS 21189249 1190231 Regulation EPHB2 THEMIS 21189249 1190237 Regulation EPHB2 TIMP1 22327365 1928219 Regulation EPHB2 TINF2 23758320 151556 Regulation EPHB2 TINF2 25629002 949893 Regulation EPHB2 TLR2 19252500 1960639 Regulation EPHB2 TLR2 20300608 3046493 Regulation EPHB2 TLR4 19399172 2415461 Regulation EPHB2 TMBIM6 24894176 682716 Regulation EPHB2 TNF 16207331 104347 Regulation EPHB2 TNF 23079107 409269 Regulation EPHB2 TNF 23800251 1627179 Regulation EPHB2 TNF 23800251 1627180 Regulation EPHB2 TNF 23800251 1627181 Regulation EPHB2 TNF 23800251 1627182 Regulation EPHB2 TNF 24352036 1632452 Regulation EPHB2 TNF 24961509 1736184 Regulation EPHB2 TNFSF10 25015549 2195792 Regulation EPHB2 TNFSF11 24244809 204692 Regulation EPHB2 TNFSF11 24244809 204720 Regulation EPHB2 TP53 23559009 561059 Regulation EPHB2 TP53 23844043 2819133 Regulation EPHB2 TP53 25196936 1730910 Regulation EPHB2 TPO 16834459 2368839 Regulation EPHB2 TPO 22792187 2661209 Regulation EPHB2 TRAF2 9432981 1602482 Regulation EPHB2 TRAF3IP2 23042150 1957925 Regulation EPHB2 TRAF3IP2 24586980 2928535 Regulation EPHB2 TRAF3IP2 24586980 2928665 Regulation EPHB2 TRAF6 23586039 181013 Regulation EPHB2 TRAF6 23586039 181186 Regulation EPHB2 TRAF6 9432981 1602412 Regulation EPHB2 TRAF6 9432981 1602427 Regulation EPHB2 TRAF6 9432981 1602446 Regulation EPHB2 TRAF6 9432981 1602471 Regulation EPHB2 TRAPPC4 24717932 1023931 Regulation EPHB2 TREM2 19399172 2415440 Regulation EPHB2 TRPC1 19680266 546150 Regulation EPHB2 TRPC5 19680266 546171 Regulation EPHB2 TRPV1 22216270 2585214 Regulation EPHB2 TSC22D3 21804606 2141536 Regulation EPHB2 TWIST1 22673193 555714 Regulation EPHB2 TYR 24129178 1113286 Regulation EPHB2 UBB 23844119 2819477 Regulation EPHB2 UBE2V1 23586039 181014 Regulation EPHB2 UBE2V1 23586039 181187 Regulation EPHB2 USP15 23105109 1205382 Regulation EPHB2 VAV1 11413196 1519515 Regulation EPHB2 VAV1 23342133 2742529 Regulation EPHB2 VAV1 25313137 2205089 Regulation EPHB2 VAV1 25313137 2205090 Regulation EPHB2 VAV1 25313137 2205099 Regulation EPHB2 VAV3 23566222 1867753 Regulation EPHB2 VAV3 23566222 1867754 Regulation EPHB2 VAV3 23566222 1867803 Regulation EPHB2 VDR 23785369 907866 Regulation EPHB2 VEGFA 12925710 1296042 Regulation EPHB2 VEGFA 23028886 2693512 Regulation EPHB2 VEGFA 23639442 700623 Regulation EPHB2 VEGFA 24119769 1700726 Regulation EPHB2 VEGFA 24586357 2924394 Regulation EPHB2 VEGFC 24046321 703712 Regulation EPHB2 VEGFC 24046321 703718 Regulation EPHB2 VIM 22536447 2622521 Regulation EPHB2 WDR61 21298035 2499470 Regulation EPHB2 WDR61 23911909 1637784 Regulation EPHB2 WNT1 19349579 1364805 Regulation EPHB2 WNT1 20011526 2433406 Regulation EPHB2 WNT1 24735639 1668010 Regulation EPHB2 WNT11 20011526 2433407 Regulation EPHB2 WNT11 24735639 1668011 Regulation EPHB2 WNT16 20011526 2433413 Regulation EPHB2 WNT16 24735639 1668016 Regulation EPHB2 WNT2 20011526 2433408 Regulation EPHB2 WNT2 24735639 1668012 Regulation EPHB2 WNT3 20011526 2433409 Regulation EPHB2 WNT3 24735639 1668013 Regulation EPHB2 WNT3A 20011526 2433412 Regulation EPHB2 WNT4 20011526 2433410 Regulation EPHB2 WNT4 24735639 1668014 Regulation EPHB2 WNT6 20011526 2433411 Regulation EPHB2 WNT6 24735639 1668015 Regulation EPHB2 XRCC5 18335053 2386987 Regulation EPHB2 XRCC6 18335053 2386990 Regulation EPHB2 YWHAB 18335053 2386969 Regulation EPHB2 YWHAB 23208503 2150237 Regulation EPHB2 YWHAB 23208503 2150270 Regulation EPHB2 ZBTB7A 23300578 2733885 Regulation EPHB2 ZC3H12A 24336080 570384 Regulation EPHB2 ZGLP1 22412973 2609912 Regulation EPHB2 ZGLP1 22412973 2609917 Regulation EPHB2 ZGLP1 22412973 2609918 Regulation EPHB2 ZGLP1 22412973 2609924 Regulation EPHB3 EFNB1 23143520 1967865 Regulation EPHB4 EFNB1 23143520 1967868 Regulation EPHB6 EFNB1 23143520 1967871 Regulation EPO PGC 25170305 1063280 Regulation EPS15 CTGF 25384022 3024594 Regulation EPS15 FUT4 23100020 1768460 Regulation EPS15 RGS2 20135898 734804 Regulation EPS8 CTGF 25384022 3024596 Regulation EPS8 FUT4 23100020 1768471 Regulation EPS8 RGS2 20135898 734805 Regulation ERBB2 EDN2 23702846 1107308 Regulation ERBB2 EPHB2 22649008 778729 Regulation ERBB2 EPHB2 25081058 612776 Regulation ERBB2 MAP2K6 21278786 2137827 Regulation ERBB3 EPHB2 24918976 620151 Regulation ERBB4 MMP28 20860838 466538 Regulation ERBB4 MMP7 20860838 466553 Regulation ERC1 MMP28 22303396 882128 Regulation ERC1 MMP7 22303396 882143 Regulation ERC2 MMP28 22303396 882150 Regulation ERC2 MMP7 22303396 882165 Regulation EREG MAP2K6 20034375 1676646 Regulation EREG RNASE1 24330607 270907 Regulation EREG RNASE1 24330607 270953 Regulation EREG RNASE7 24330607 270916 Regulation EREG RNASE7 24330607 270962 Regulation EREG SPHK1 21936950 1697752 Regulation ERF MAP2K6 21599960 1898298 Regulation ERG TNF 19460151 1625335 Regulation ERVK-6 EPHB2 19144181 112439 Regulation ERVK-6 MAP2K6 19144181 112445 Regulation ESPL1 FOXO1 22645648 2208385 Regulation ESPL1 FOXO1 22645648 2208389 Regulation ESR1 FOXA1 24339902 2894129 Regulation ESR1 SPHK1 25153718 2198618 Regulation ETS1 EPHB2 15972796 2016775 Regulation ETS1 EPHB2 25210949 1484881 Regulation ETS1 EPHB2 25210949 1484884 Regulation ETS1 EPHB2 25210949 1484886 Regulation ETS1 EPHB2 25294825 2105173 Regulation ETS1 EPHB2 25294825 2105206 Regulation ETS1 EPHB2 25294825 2105214 Regulation ETS2 UCA1 24069250 2852278 Regulation ETS2 UCA1 24069250 2852283 Regulation ETV4 EPHB2 21087211 148183 Regulation ETV4 EPHB2 21087211 148190 Regulation ETV5 EPHB2 21087211 148184 Regulation ETV5 EPHB2 21087211 148191 Regulation ETV6 FOXO1 17010188 232455 Regulation ETV7 DKC1 22291956 2591378 Regulation ETV7 HSP90AA1 22291956 2591379 Regulation ETV7 PTGES3 22291956 2591377 Regulation ETV7 TERT 22291956 2591376 Regulation EXT1 MMP28 23613970 2782932 Regulation EYA1 EPHB2 23251383 2727927 Regulation EYA1 EPHB2 23251383 2728043 Regulation EYA2 EPHB2 23251383 2727928 Regulation EYA2 EPHB2 23251383 2728044 Regulation EYA3 EPHB2 23251383 2727929 Regulation EYA3 EPHB2 23251383 2728045 Regulation EYA4 EPHB2 23251383 2727930 Regulation EYA4 EPHB2 23251383 2728046 Regulation EZH2 EPHB2 24168056 1700781 Regulation EZH2 TNF 20814569 2473461 Regulation EZR CAPN8 22073041 923757 Regulation EZR CAPN8 22073041 923785 Regulation EZR CAPN8 22073041 923813 Regulation EZR CAPN8 9566966 1467277 Regulation EZR CAPN8 9566966 1467333 Regulation EZR CAPN8 9566966 1467421 Regulation F10 EPHB2 23066391 1076877 Regulation F10 F3 16221316 658595 Regulation F10 SRGN 24286332 222297 Regulation F10 TFPI2 22022598 2563992 Regulation F11R CLDN10 23885123 1817458 Regulation F2 F3 19873354 1609482 Regulation F2R AHSA1 21029417 354077 Regulation F2R AP1B1 21966428 2557701 Regulation F2R AP1G1 21966428 2557702 Regulation F2R APC 17893198 1547101 Regulation F2R ATRX 18842153 324271 Regulation F2R CTGF 22212430 14251 Regulation F2R CTSG 24453410 1756640 Regulation F2R F2RL3 21721170 29565 Regulation F2R FLNA 20713593 1559583 Regulation F2R FYN 19917775 1556771 Regulation F2R GAST 24278414 2885901 Regulation F2R GLTSCR2 19917775 1556772 Regulation F2R GRB10 22952817 2684148 Regulation F2R GRB14 22952817 2684149 Regulation F2R GRB2 22952817 2684150 Regulation F2R GRB7 22952817 2684151 Regulation F2R GRK5 24807909 1823558 Regulation F2R IL1A 16808851 1654917 Regulation F2R LGALS3 21966428 2557687 Regulation F2R LGALS3 21966428 2557703 Regulation F2R MAPK3 21029417 354078 Regulation F2R MAPK3 21029417 354161 Regulation F2R MET 25386346 3092731 Regulation F2R MMP1 22992722 988782 Regulation F2R PITX2 24743392 2955482 Regulation F2R PLG 23431500 2234761 Regulation F2R S1PR1 22518344 1082542 Regulation F2R SHH 25386346 3092730 Regulation F2RL1 F2R 21029417 354024 Regulation F2RL1 F2R 24215724 538156 Regulation F2RL1 F3 22973554 941226 Regulation F2RL2 TNF 21667320 3211477 Regulation F3 CXCL2 18755030 324109 Regulation F3 DPP4 22167343 142816 Regulation F3 F2RL1 22973554 941231 Regulation F8 TNF 22115311 1697986 Regulation F8 TNF 25422582 743485 Regulation FABP7 NR2F1 20111703 2438544 Regulation FABP7 NR2F1 20111703 2438546 Regulation FABP7 NR2F1 20111703 2438547 Regulation FADD FAS 19118384 1983119 Regulation FADD TNF 19373245 546131 Regulation FADD TNF 22666585 2009604 Regulation FADD TNFSF10 18992144 251790 Regulation FAH TNF 1989665 433965 Regulation FAH TNF 1989665 433966 Regulation FAH TNF 1989668 433969 Regulation FAIM2 EPHB2 23029562 2698763 Regulation FAIM2 EPHB2 23029562 2698800 Regulation FAIM2 EPHB2 23029562 2698818 Regulation FAIM2 EPHB2 23029562 2698819 Regulation FAIM2 EPHB2 23029562 2698839 Regulation FAIM2 FAS 23029562 2698799 Regulation FAIM3 CHI3L1 19414556 1554754 Regulation FAM107A GADD45B 20525385 329215 Regulation FAM129B EPHB2 24358901 848671 Regulation FANCD2 TP63 24823795 2100822 Regulation FAP MYH16 20223042 1029805 Regulation FAP MYH3 20223042 1029812 Regulation FAR1 FHL1 18670649 2305649 Regulation FAS ABCC6 21244676 1723417 Regulation FAS ABCC6 21244676 1723418 Regulation FAS ACO1 21599965 332899 Regulation FAS ACO2 21599965 332900 Regulation FAS AGXT 17999750 352074 Regulation FAS AKT1 11457886 1519829 Regulation FAS AKT1 19936232 2431774 Regulation FAS AKT1 19936232 2431806 Regulation FAS AKT1 22824368 1724883 Regulation FAS AKT1 22949843 1098057 Regulation FAS AKT1 23316192 905632 Regulation FAS AKT1S1 23676995 589638 Regulation FAS AKT2 19936232 2431775 Regulation FAS AKT2 19936232 2431807 Regulation FAS AKT2 23316192 905633 Regulation FAS AKT3 19936232 2431776 Regulation FAS AKT3 19936232 2431808 Regulation FAS AKT3 23316192 905634 Regulation FAS APC 22908306 1399410 Regulation FAS ARHGEF2 25107365 1488251 Regulation FAS ATG10 21887385 2549814 Regulation FAS ATG10 21887385 2549815 Regulation FAS ATG12 21887385 2549820 Regulation FAS ATG12 21887385 2549821 Regulation FAS ATG13 21887385 2549818 Regulation FAS ATG13 21887385 2549819 Regulation FAS ATG14 21887385 2549812 Regulation FAS ATG14 21887385 2549813 Regulation FAS ATG3 21887385 2549816 Regulation FAS ATG3 21887385 2549817 Regulation FAS ATG5 21887385 2549822 Regulation FAS ATG5 21887385 2549823 Regulation FAS ATG7 21887385 2549810 Regulation FAS ATG7 21887385 2549811 Regulation FAS BCL2 17031406 428234 Regulation FAS BHLHE40 18838394 2036780 Regulation FAS BHLHE41 18838394 2036711 Regulation FAS BHLHE41 18838394 2036782 Regulation FAS BRCA1 25594018 2173723 Regulation FAS BRCA1 25594018 2173728 Regulation FAS BRCA1 25594018 2173735 Regulation FAS C3 21573156 2522697 Regulation FAS CA2 21713032 2276641 Regulation FAS CASP1 9334376 1601781 Regulation FAS CASP10 21049020 2480444 Regulation FAS CASP2 24350060 864564 Regulation FAS CASP8 10704075 1736865 Regulation FAS CASP8 16129703 1537084 Regulation FAS CASP8 23889969 294620 Regulation FAS CAV1 24131997 1819383 Regulation FAS CD36 24275630 1158368 Regulation FAS CD4 16636134 1540119 Regulation FAS CD4 21573156 2522698 Regulation FAS CD40 22194871 2583069 Regulation FAS CD40 9892626 1605119 Regulation FAS CD40LG 22848207 902710 Regulation FAS CD40LG 22848207 902717 Regulation FAS CD74 25304249 1510816 Regulation FAS CD74 25304249 1510817 Regulation FAS CD8A 16636134 1540127 Regulation FAS CFL1 24901238 3068131 Regulation FAS CFLAR 22348197 497095 Regulation FAS CFLAR 22875006 557319 Regulation FAS CFLAR 22875006 557323 Regulation FAS CFLAR 25379355 1243453 Regulation FAS CPOX 19159447 2112482 Regulation FAS CPOX 19159447 2112483 Regulation FAS CPT1A 21599965 332901 Regulation FAS CRK 20877355 435993 Regulation FAS CTLA4 19052636 2401808 Regulation FAS DGAT2 23593473 2781455 Regulation FAS DLG1 18070911 1346823 Regulation FAS DLG2 18070911 1346824 Regulation FAS DLG3 18070911 1346825 Regulation FAS DLG4 18070911 1346826 Regulation FAS DLG5 18070911 1346827 Regulation FAS DNMT3A 22507896 799387 Regulation FAS DST 22662114 2647022 Regulation FAS DST 22662114 2647023 Regulation FAS ECM1 24065163 1730255 Regulation FAS ECM2 24065163 1730256 Regulation FAS EGR1 20087343 434323 Regulation FAS EPHB2 22046349 2566535 Regulation FAS EZR 21151158 12248 Regulation FAS FADD 19118384 1983118 Regulation FAS FADD 23737986 2799844 Regulation FAS FAS 18070911 1346807 Regulation FAS FAS 19118384 1983117 Regulation FAS FASLG 12110144 99305 Regulation FAS FASLG 15795317 1319315 Regulation FAS FASLG 21264287 2495209 Regulation FAS FASLG 23840885 2818324 Regulation FAS FLOT2 23671449 95730 Regulation FAS FOXL2 24240106 1685254 Regulation FAS FOXP3 22905732 356042 Regulation FAS G6PD 25272231 1131551 Regulation FAS GAB2 21118992 1783637 Regulation FAS GADD45A 22986526 2148755 Regulation FAS GLI3 24044691 294978 Regulation FAS GOT2 23382926 2746803 Regulation FAS HMOX1 20979658 1723386 Regulation FAS HRAS 22046349 2566536 Regulation FAS IFNG 15899041 103697 Regulation FAS IFNG 18474096 110754 Regulation FAS IGF1 19091070 352512 Regulation FAS IGF1 19091070 352523 Regulation FAS IL10 19756150 2426526 Regulation FAS IL12A 7500020 1587118 Regulation FAS IL12B 7500020 1587119 Regulation FAS IL2 7504062 1588770 Regulation FAS IL6 19091070 352513 Regulation FAS IL6 19091070 352524 Regulation FAS IL7 22194871 2583076 Regulation FAS IL7 22194871 2583108 Regulation FAS INS 21471514 719051 Regulation FAS INS 22676303 1724634 Regulation FAS INS 24026559 730229 Regulation FAS INSIG1 21843373 1229509 Regulation FAS JUN 11250803 789816 Regulation FAS JUN 19806201 2427734 Regulation FAS KRAS 10662780 1255845 Regulation FAS KRAS 22046349 2566537 Regulation FAS KRR1 20038679 1370001 Regulation FAS LUM 24558602 1154269 Regulation FAS LYN 9064343 1600351 Regulation FAS MAPRE3 23712260 1405204 Regulation FAS MLST8 23676995 589637 Regulation FAS MLXIPL 22111040 730345 Regulation FAS MSH2 11641530 1632767 Regulation FAS MSH2 11641530 1632792 Regulation FAS MSH3 11641530 1632768 Regulation FAS MSH3 11641530 1632793 Regulation FAS MSH4 11641530 1632769 Regulation FAS MSH4 11641530 1632794 Regulation FAS MSH5 11641530 1632770 Regulation FAS MSH5 11641530 1632795 Regulation FAS MSH6 11641530 1632771 Regulation FAS MSH6 11641530 1632796 Regulation FAS MTOR 23676995 589640 Regulation FAS MTOR 24648839 1074027 Regulation FAS MYL2 23551528 1480249 Regulation FAS MYLIP 22479460 2615484 Regulation FAS MYLIP 22479460 2615491 Regulation FAS MYLIP 24430730 3139381 Regulation FAS MYLIP 25552935 1063943 Regulation FAS MYLIP 25552935 1063948 Regulation FAS MYLK 20037648 2435348 Regulation FAS NAALADL1 21912564 633129 Regulation FAS NFATC2IP 23170112 842641 Regulation FAS NFKB1 22382690 438357 Regulation FAS NRAS 22046349 2566538 Regulation FAS P2RX7 22789015 1664441 Regulation FAS PIK3CA 19798413 2427533 Regulation FAS PIK3CA 19798413 2427583 Regulation FAS PIK3CA 19798413 2427587 Regulation FAS PIK3CA 19798413 2427591 Regulation FAS PIK3CA 23316192 905635 Regulation FAS PIK3R1 19798413 2427534 Regulation FAS PIK3R1 19798413 2427584 Regulation FAS PIK3R1 19798413 2427588 Regulation FAS PIK3R1 19798413 2427592 Regulation FAS PIK3R1 23316192 905636 Regulation FAS PLEC 20702585 1779847 Regulation FAS POU2F1 25178366 136746 Regulation FAS PRDX2 23640463 561723 Regulation FAS PRKAA1 25049694 136345 Regulation FAS PRKAA2 25049694 136346 Regulation FAS PRKAB1 25049694 136347 Regulation FAS PRKAB2 25049694 136348 Regulation FAS PRKAG1 25049694 136349 Regulation FAS PRKAG2 25049694 136350 Regulation FAS PRL PMC3300591 477020 Regulation FAS PRLR PMC3300591 477021 Regulation FAS PTBP1 24957602 2102143 Regulation FAS PTEN 22949843 1098053 Regulation FAS PTEN 22949843 1098058 Regulation FAS PTEN 22949843 1098059 Regulation FAS PTGS2 19159447 2112484 Regulation FAS PTGS2 21209926 2492459 Regulation FAS PTK2 24683541 187633 Regulation FAS PTK6 24683541 187634 Regulation FAS PTK7 24683541 187635 Regulation FAS PTPN11 21118992 1783689 Regulation FAS PUM1 24901238 3068118 Regulation FAS PUM1 24901238 3068122 Regulation FAS PUM1 24901238 3068130 Regulation FAS RAF1 11157988 1267362 Regulation FAS RAF1 16365167 1326358 Regulation FAS RAF1 16365167 1326371 Regulation FAS RASA1 10769036 1257234 Regulation FAS RELA 10075983 1511258 Regulation FAS RELA 22382690 438358 Regulation FAS RHO 10769036 1257233 Regulation FAS RHOC 23825001 2809333 Regulation FAS RIPK2 24658576 2937876 Regulation FAS ROCK1 20037648 2435346 Regulation FAS ROCK2 20037648 2435347 Regulation FAS RPS20 22929310 1506544 Regulation FAS RPTOR 23676995 589639 Regulation FAS RPTOR 24648839 1074026 Regulation FAS RRM1 24957602 2102141 Regulation FAS RRM2 24957602 2102142 Regulation FAS SEC14L2 23519612 2086296 Regulation FAS SEC14L2 24285959 1070279 Regulation FAS SLC25A16 22087285 2571216 Regulation FAS SP1 19936232 2431804 Regulation FAS SP1 21687747 922428 Regulation FAS SP3 19936232 2431805 Regulation FAS SP3 21687747 922429 Regulation FAS SPN 10601365 1513779 Regulation FAS SPN 10601365 1513780 Regulation FAS SRC 19190626 431732 Regulation FAS SRC 22291036 1394925 Regulation FAS SREBF1 18838394 2036781 Regulation FAS SREBF1 20173757 9476 Regulation FAS SREBF1 20173757 9480 Regulation FAS SREBF1 20173757 9484 Regulation FAS SREBF1 20205889 2112624 Regulation FAS SREBF1 22111040 730344 Regulation FAS SREBF1 22844333 814862 Regulation FAS SREBF1 23304111 3076104 Regulation FAS SREBF1 23382926 2746802 Regulation FAS SREBF1 24067358 3137277 Regulation FAS SREBF1 24625548 2933797 Regulation FAS SREBF1 24678767 1726829 Regulation FAS SREBF1 24843688 1494553 Regulation FAS SREBF1 25250914 1131019 Regulation FAS SREBF1 25609476 3149803 Regulation FAS STAT1 15296508 523863 Regulation FAS TCF12 24876678 1759153 Regulation FAS TCF15 24876678 1759154 Regulation FAS TCF19 24876678 1759155 Regulation FAS TCF20 24876678 1759156 Regulation FAS TCF21 24876678 1759157 Regulation FAS TCF23 24876678 1759161 Regulation FAS TCF24 24876678 1759163 Regulation FAS TCF25 24876678 1759162 Regulation FAS TCF3 24876678 1759158 Regulation FAS TCF4 24876678 1759159 Regulation FAS TCF7 24876678 1759160 Regulation FAS TGM7 18021457 250644 Regulation FAS TLR4 20964825 855121 Regulation FAS TLR4 22529965 2620749 Regulation FAS TNF 11581316 1521088 Regulation FAS TNF 11581316 1521089 Regulation FAS TNF 18474096 110753 Regulation FAS TNF 20122254 243379 Regulation FAS TNF 20122254 243380 Regulation FAS TNF 21781333 656620 Regulation FAS TNF 21850048 552443 Regulation FAS TNF 24465826 2911829 Regulation FAS TNFRSF1A 21789261 2538372 Regulation FAS TNFRSF1A 21850048 552444 Regulation FAS TNFRSF1B 17254331 166006 Regulation FAS TNFSF11 23300516 2733562 Regulation FAS TNFSF13B 11015437 1517313 Regulation FAS TNFSF13B 11015437 1517315 Regulation FAS TNMD 23825001 2809332 Regulation FAS TP53 12923319 1634163 Regulation FAS TP53 15038834 382346 Regulation FAS TP53 15559377 630343 Regulation FAS TP53 16709241 1845263 Regulation FAS TP53 18237448 361443 Regulation FAS TP53 23166734 2718826 Regulation FAS TP53 23762486 2803685 Regulation FAS TP53 24622841 3081744 Regulation FAS TP53 24980819 2194735 Regulation FAS TP53 25392688 490143 Regulation FAS TP53 9841917 1604748 Regulation FAS TP53 9841917 1604751 Regulation FAS TRIP6 16880273 1331775 Regulation FAS TRIP6 16880273 1331777 Regulation FAS VAV1 21151158 12247 Regulation FAS VCL 18056416 1346756 Regulation FAS ZMAT3 24469038 2154623 Regulation FAS ZMAT3 24469038 2154639 Regulation FAS ZMAT3 24469038 2154641 Regulation FASLG ANGPT1 23554782 1226184 Regulation FASLG FAS 12177809 421999 Regulation FASLG FAS 15148335 1532703 Regulation FASLG FAS 16186185 1537912 Regulation FASLG FAS 23372642 2745535 Regulation FASLG FAS 23840885 2818325 Regulation FASLG FOXO1 16336649 656501 Regulation FASLG FOXO1 18648506 2393415 Regulation FASLG TNF 20664736 1709772 Regulation FASLG TNF 21781333 656621 Regulation FASLG TNF 23372642 2745534 Regulation FASLG TNF 24465826 2911830 Regulation FAU PLAU 9662256 447320 Regulation FBN1 TGM2 24921197 653868 Regulation FBXO32 FOXO1 23555761 2775255 Regulation FBXO32 FOXO1 24550841 964122 Regulation FBXO32 FOXO1 24550841 964133 Regulation FBXO32 FOXO1 25032690 2990181 Regulation FBXO32 FOXO3 22586590 722914 Regulation FBXO32 FOXO3 22586590 722920 Regulation FBXO32 FOXO3 23374633 245359 Regulation FBXO32 FOXO3 23374633 245378 Regulation FBXO32 FOXO3 23922868 2826919 Regulation FBXO32 FOXO3 24292657 2301733 Regulation FBXO32 FOXO3 24550841 964123 Regulation FBXO32 FOXO3 24550841 964134 Regulation FBXO32 FOXO3 25032690 2990182 Regulation FBXO32 FOXO4 24550841 964124 Regulation FBXO32 FOXO6 24550841 964121 Regulation FBXO32 MPI 23437325 2756460 Regulation FBXO32 MPI 23437325 2756462 Regulation FBXO32 MYOG 21264243 2494883 Regulation FBXO32 RNF19A 23046544 3161180 Regulation FBXO32 SIRT1 22476871 1238659 Regulation FBXO32 TNF 23378678 3610 Regulation FBXO32 TRAF6 21187332 1384551 Regulation FBXO32 TRIM63 23024748 2689688 Regulation FBXO32 TRIM63 24292657 2301732 Regulation FBXO4 CCND1 18764945 583292 Regulation FBXW11 TNF 25071782 913484 Regulation FCER2 TNF 22666666 1920918 Regulation FCGBP CADM1 22152070 262807 Regulation FCGBP CADM2 22152070 262805 Regulation FCGBP CADM3 22152070 262804 Regulation FCGBP CADM4 22152070 262806 Regulation FDPS CLU 25138053 2198207 Regulation FGA FOXA1 24093963 345442 Regulation FGB HES2 20028511 659393 Regulation FGB TNF 7519620 1436164 Regulation FGF1 EPHB2 18442396 323312 Regulation FGF1 FGFBP1 22111880 1864226 Regulation FGF1 MAP2K6 18442396 323318 Regulation FGF1 MSX1 22383889 2332150 Regulation FGF10 EPHB2 18442396 323321 Regulation FGF10 FGFBP1 22111880 1864227 Regulation FGF10 MAP2K6 18442396 323327 Regulation FGF10 MSX1 22383889 2332152 Regulation FGF11 EPHB2 18442396 323330 Regulation FGF11 FGFBP1 22111880 1864228 Regulation FGF11 MAP2K6 18442396 323336 Regulation FGF11 MSX1 22383889 2332154 Regulation FGF12 EPHB2 18442396 323339 Regulation FGF12 FGFBP1 22111880 1864229 Regulation FGF12 MAP2K6 18442396 323345 Regulation FGF12 MSX1 22383889 2332156 Regulation FGF13 EPHB2 18442396 323348 Regulation FGF13 FGFBP1 22111880 1864230 Regulation FGF13 MAP2K6 18442396 323354 Regulation FGF13 MSX1 22383889 2332158 Regulation FGF14 EPHB2 18442396 323357 Regulation FGF14 FGFBP1 22111880 1864231 Regulation FGF14 MAP2K6 18442396 323363 Regulation FGF14 MSX1 22383889 2332160 Regulation FGF16 EPHB2 18442396 323366 Regulation FGF16 FGFBP1 22111880 1864232 Regulation FGF16 MAP2K6 18442396 323372 Regulation FGF16 MSX1 22383889 2332162 Regulation FGF17 EPHB2 18442396 323375 Regulation FGF17 FGFBP1 22111880 1864233 Regulation FGF17 MAP2K6 18442396 323381 Regulation FGF17 MSX1 22383889 2332164 Regulation FGF18 EPHB2 18442396 323384 Regulation FGF18 FGFBP1 22111880 1864234 Regulation FGF18 MAP2K6 18442396 323390 Regulation FGF18 MSX1 22383889 2332166 Regulation FGF19 EPHB2 18442396 323393 Regulation FGF19 FGFBP1 22111880 1864235 Regulation FGF19 MAP2K6 18442396 323399 Regulation FGF19 MSX1 22383889 2332168 Regulation FGF2 ANGPT1 12070283 1523614 Regulation FGF2 EDN2 23469133 2762019 Regulation FGF2 EPHB2 18442396 323402 Regulation FGF2 EPHB2 24827991 2969855 Regulation FGF2 EPHB2 24827991 2969856 Regulation FGF2 FGFBP1 22111880 1864236 Regulation FGF2 IL1B 19954533 2232854 Regulation FGF2 MAP2K6 18442396 323408 Regulation FGF2 MMP28 16286510 1325410 Regulation FGF2 MMP28 23227251 2725888 Regulation FGF2 MMP28 24260208 2882760 Regulation FGF2 MMP7 16286510 1325425 Regulation FGF2 MMP7 23227251 2725907 Regulation FGF2 MMP7 24260208 2882779 Regulation FGF2 MSX1 22383889 2332170 Regulation FGF2 S100B 22276098 2589919 Regulation FGF2 S100B 22276098 2589960 Regulation FGF2 TNF 19014534 2232743 Regulation FGF2 TNF 19014534 2232744 Regulation FGF2 TNF 19014534 2232745 Regulation FGF2 TNF 19014534 2232746 Regulation FGF2 TNF 19014534 2232767 Regulation FGF2 TNF 19014534 2232772 Regulation FGF2 TNF 24008729 565518 Regulation FGF20 EPHB2 18442396 323411 Regulation FGF20 FGFBP1 22111880 1864237 Regulation FGF20 MAP2K6 18442396 323417 Regulation FGF20 MSX1 22383889 2332172 Regulation FGF21 EPHB2 18442396 323420 Regulation FGF21 FGFBP1 22111880 1864238 Regulation FGF21 MAP2K6 18442396 323426 Regulation FGF21 MSX1 22383889 2332174 Regulation FGF21 PGC 21331285 1669715 Regulation FGF21 PGC 23451284 2758550 Regulation FGF21 PGC 24605108 880203 Regulation FGF21 PGC 24744913 2251863 Regulation FGF22 EPHB2 18442396 323429 Regulation FGF22 FGFBP1 22111880 1864239 Regulation FGF22 MAP2K6 18442396 323435 Regulation FGF22 MSX1 22383889 2332176 Regulation FGF23 CYP24A1 24718641 2950982 Regulation FGF23 EPHB2 18442396 323438 Regulation FGF23 FGFBP1 22111880 1864240 Regulation FGF23 MAP2K6 18442396 323444 Regulation FGF23 MSX1 22383889 2332178 Regulation FGF3 CCND1 18703590 2035919 Regulation FGF3 EPHB2 18442396 323447 Regulation FGF3 FGFBP1 22111880 1864241 Regulation FGF3 MAP2K6 18442396 323453 Regulation FGF3 MSX1 22383889 2332180 Regulation FGF4 EPHB2 18442396 323456 Regulation FGF4 FGFBP1 22111880 1864242 Regulation FGF4 MAP2K6 18442396 323462 Regulation FGF4 MSX1 22383889 2332182 Regulation FGF5 EPHB2 18442396 323465 Regulation FGF5 FGFBP1 22111880 1864243 Regulation FGF5 MAP2K6 18442396 323471 Regulation FGF5 MSX1 22383889 2332184 Regulation FGF6 EPHB2 18442396 323474 Regulation FGF6 FGFBP1 22111880 1864244 Regulation FGF6 MAP2K6 18442396 323480 Regulation FGF6 MSX1 22383889 2332186 Regulation FGF7 EPHB2 18442396 323483 Regulation FGF7 FGFBP1 22111880 1864245 Regulation FGF7 MAP2K6 18442396 323489 Regulation FGF7 MSX1 22383889 2332188 Regulation FGF8 EPHB2 18442396 323492 Regulation FGF8 FGFBP1 22111880 1864246 Regulation FGF8 MAP2K6 18442396 323498 Regulation FGF8 MSX1 22383889 2332190 Regulation FGF8 MSX1 24160254 345735 Regulation FGF9 EPHB2 18442396 323501 Regulation FGF9 FGFBP1 22111880 1864247 Regulation FGF9 MAP2K6 18442396 323507 Regulation FGF9 MSX1 22383889 2332192 Regulation FGFR1 CCND1 19330026 2125004 Regulation FGFR1 FZD4 25277175 2202888 Regulation FGFR1 HRH1 23497494 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2328440 Regulation FOXO1 MAPKAPK5 23878308 1572795 Regulation FOXO1 MDM2 18665269 2394182 Regulation FOXO1 MDM2 18665269 2394231 Regulation FOXO1 MED23 25223702 612822 Regulation FOXO1 MIR17HG 23983402 1754582 Regulation FOXO1 MLST8 23183047 1569958 Regulation FOXO1 MLST8 23183047 1570052 Regulation FOXO1 MLST8 23183047 1570167 Regulation FOXO1 MLST8 23183047 1570241 Regulation FOXO1 MLST8 24255720 2882070 Regulation FOXO1 MLST8 24633152 2934673 Regulation FOXO1 MLST8 24633152 2934701 Regulation FOXO1 MMP14 25162582 3002913 Regulation FOXO1 MRRF 22574120 2631818 Regulation FOXO1 MTOR 22489168 1095460 Regulation FOXO1 MTOR 23183047 1569960 Regulation FOXO1 MTOR 23183047 1570054 Regulation FOXO1 MTOR 23183047 1570169 Regulation FOXO1 MTOR 23183047 1570243 Regulation FOXO1 MTOR 24255720 2882072 Regulation FOXO1 MTOR 24633152 2934675 Regulation FOXO1 MTOR 24633152 2934703 Regulation FOXO1 MUT 21541341 2516992 Regulation FOXO1 MYC 24977668 2194644 Regulation FOXO1 MYC PMC3395103 395718 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FOXO1 PIK3CA 20565782 1676912 Regulation FOXO1 PIK3CA 20657733 2456302 Regulation FOXO1 PIK3CA 20868529 1647859 Regulation FOXO1 PIK3CA 22621320 150597 Regulation FOXO1 PIK3CA 22888331 903259 Regulation FOXO1 PIK3CA 24024143 3093181 Regulation FOXO1 PIK3CA 24162775 1959294 Regulation FOXO1 PIK3CA 24836538 2971284 Regulation FOXO1 PIK3CA 24876677 1759015 Regulation FOXO1 PIK3CA 25157276 1240806 Regulation FOXO1 PIK3R1 15353558 1533381 Regulation FOXO1 PIK3R1 15353558 1533425 Regulation FOXO1 PIK3R1 17997602 3040248 Regulation FOXO1 PIK3R1 19043547 2306839 Regulation FOXO1 PIK3R1 19043547 2306861 Regulation FOXO1 PIK3R1 19243599 282194 Regulation FOXO1 PIK3R1 20565782 1676913 Regulation FOXO1 PIK3R1 20657733 2456303 Regulation FOXO1 PIK3R1 20868529 1647860 Regulation FOXO1 PIK3R1 22621320 150598 Regulation FOXO1 PIK3R1 22888331 903260 Regulation FOXO1 PIK3R1 24024143 3093182 Regulation FOXO1 PIK3R1 24162775 1959295 Regulation FOXO1 PIK3R1 24836538 2971285 Regulation FOXO1 PIK3R1 24876677 1759016 Regulation FOXO1 PIK3R1 25157276 1240807 Regulation FOXO1 POLDIP2 23046544 3161216 Regulation FOXO1 PPARA 23372643 2745551 Regulation FOXO1 PPARG 21615920 397987 Regulation FOXO1 PPP3CA 23805378 749508 Regulation FOXO1 PPP3R1 23805378 749509 Regulation FOXO1 PRDX2 24977668 2194673 Regulation FOXO1 PRKAA1 21386086 718261 Regulation FOXO1 PRKAA1 24385923 2354779 Regulation FOXO1 PRKAA1 25026276 2195889 Regulation FOXO1 PRKAA2 21386086 718262 Regulation FOXO1 PRKAA2 24385923 2354780 Regulation FOXO1 PRKAA2 25026276 2195890 Regulation FOXO1 PRKAB1 21386086 718263 Regulation FOXO1 PRKAB1 24385923 2354781 Regulation FOXO1 PRKAB1 25026276 2195891 Regulation FOXO1 PRKAB2 21386086 718264 Regulation FOXO1 PRKAB2 24385923 2354782 Regulation FOXO1 PRKAB2 25026276 2195892 Regulation FOXO1 PRKAG1 21386086 718265 Regulation FOXO1 PRKAG1 24385923 2354783 Regulation FOXO1 PRKAG1 25026276 2195893 Regulation FOXO1 PRKAG2 21386086 718266 Regulation FOXO1 PRKAG2 24385923 2354784 Regulation FOXO1 PRKAG2 25026276 2195894 Regulation FOXO1 PSMA1 23277279 610811 Regulation FOXO1 PSMA2 23277279 610812 Regulation FOXO1 PSMA3 23277279 610813 Regulation FOXO1 PSMA4 23277279 610814 Regulation FOXO1 PSMA5 23277279 610815 Regulation FOXO1 PSMA6 23277279 610816 Regulation FOXO1 PSMA7 23277279 610817 Regulation FOXO1 PSMB1 23277279 610818 Regulation FOXO1 PSMB2 23277279 610819 Regulation FOXO1 PSMB3 23277279 610820 Regulation FOXO1 PSMB4 23277279 610821 Regulation FOXO1 PSMB5 23277279 610822 Regulation FOXO1 PSMB6 23277279 610823 Regulation FOXO1 PSMB7 23277279 610824 Regulation FOXO1 PTMS 20567500 2453176 Regulation FOXO1 PTMS 24525530 1940621 Regulation FOXO1 RALA 12844367 298082 Regulation FOXO1 RENBP 17447841 3039593 Regulation FOXO1 RENBP 20300563 1910592 Regulation FOXO1 RENBP 20300563 1910593 Regulation FOXO1 RENBP 20300563 1910600 Regulation FOXO1 RICTOR 24255720 2882071 Regulation FOXO1 RICTOR 24633152 2934674 Regulation FOXO1 RICTOR 24633152 2934702 Regulation FOXO1 RPTOR 22489168 1095459 Regulation FOXO1 RPTOR 23183047 1569959 Regulation FOXO1 RPTOR 23183047 1570053 Regulation FOXO1 RPTOR 23183047 1570168 Regulation FOXO1 RPTOR 23183047 1570242 Regulation FOXO1 SCGB1D4 20975207 28376 Regulation FOXO1 SCGB1D4 22016799 2562883 Regulation FOXO1 SCGB1D4 22511947 2619016 Regulation FOXO1 SCGB1D4 23906066 700874 Regulation FOXO1 SCN5A 22400069 2608781 Regulation FOXO1 SELL 22888331 903200 Regulation FOXO1 SELL 23183047 1570164 Regulation FOXO1 SETD2 19152120 1478392 Regulation FOXO1 SETD2 23183047 1569957 Regulation FOXO1 SETD2 23183047 1570051 Regulation FOXO1 SETD2 23183047 1570166 Regulation FOXO1 SETD2 23183047 1570240 Regulation FOXO1 SGK1 20657733 2456324 Regulation FOXO1 SGK1 20657733 2456351 Regulation FOXO1 SGK1 22359667 2598771 Regulation FOXO1 SGK1 23786484 32873 Regulation FOXO1 SGK1 23786484 33026 Regulation FOXO1 SGK1 23786484 33027 Regulation FOXO1 SGK1 23786484 33028 Regulation FOXO1 SGK1 23786484 33126 Regulation FOXO1 SGK1 23786484 33127 Regulation FOXO1 SGK1 23786484 33234 Regulation FOXO1 SGK1 23786484 33247 Regulation FOXO1 SGTA 19007433 226812 Regulation FOXO1 SIRT1 16441841 32418 Regulation FOXO1 SIRT1 18781224 1054981 Regulation FOXO1 SIRT1 21087523 1696909 Regulation FOXO1 SIRT1 21566744 3188796 Regulation FOXO1 SIRT1 21596782 2063183 Regulation FOXO1 SIRT1 21909281 2326098 Regulation FOXO1 SIRT1 21909281 2326141 Regulation FOXO1 SIRT1 21909281 2326142 Regulation FOXO1 SIRT1 21909281 2326155 Regulation FOXO1 SIRT1 21909281 2326251 Regulation FOXO1 SIRT1 22983125 542044 Regulation FOXO1 SIRT1 24009212 781950 Regulation FOXO1 SIRT1 24040102 2845685 Regulation FOXO1 SIRT1 24069505 2226957 Regulation FOXO1 SIRT1 25044690 2119622 Regulation FOXO1 SIRT1 25386563 1496745 Regulation FOXO1 SIRT2 21566744 3188791 Regulation FOXO1 SIRT6 25133775 2998865 Regulation FOXO1 SKP2 18665269 2394204 Regulation FOXO1 SMAD6 24145169 1411678 Regulation FOXO1 SPAG8 20975207 28386 Regulation FOXO1 SPDYA 22280365 263367 Regulation FOXO1 SPRY1 23554919 2773813 Regulation FOXO1 SPRY1 23554919 2773855 Regulation FOXO1 SPRY4 23554919 2773814 Regulation FOXO1 ST3GAL4 23401241 779874 Regulation FOXO1 STAT1 23401241 779864 Regulation FOXO1 STAT1 23401241 779869 Regulation FOXO1 STS 24077633 18485 Regulation FOXO1 STS 24077633 18498 Regulation FOXO1 TARDBP 25329970 2366511 Regulation FOXO1 TARDBP 25329970 2366512 Regulation FOXO1 TARDBP 25329970 2366535 Regulation FOXO1 TARDBP 25329970 2366539 Regulation FOXO1 TCF12 23786484 33029 Regulation FOXO1 TCF15 23786484 33030 Regulation FOXO1 TCF19 23786484 33031 Regulation FOXO1 TCF20 23786484 33032 Regulation FOXO1 TCF21 23786484 33033 Regulation FOXO1 TCF23 23786484 33037 Regulation FOXO1 TCF24 23786484 33040 Regulation FOXO1 TCF25 23786484 33039 Regulation FOXO1 TCF3 23786484 33034 Regulation FOXO1 TCF4 23786484 33035 Regulation FOXO1 TCF7 23786484 33036 Regulation FOXO1 TIMP3 23401241 779875 Regulation FOXO1 TLR1 24740015 2953871 Regulation FOXO1 TLR1 24740015 2954388 Regulation FOXO1 TLR10 24740015 2953879 Regulation FOXO1 TLR10 24740015 2954396 Regulation FOXO1 TLR2 24740015 2953872 Regulation FOXO1 TLR2 24740015 2954389 Regulation FOXO1 TLR3 24740015 2953873 Regulation FOXO1 TLR3 24740015 2954390 Regulation FOXO1 TLR4 24740015 2953874 Regulation FOXO1 TLR4 24740015 2954391 Regulation FOXO1 TLR5 24740015 2953875 Regulation FOXO1 TLR5 24740015 2954392 Regulation FOXO1 TLR6 24740015 2953880 Regulation FOXO1 TLR6 24740015 2954397 Regulation FOXO1 TLR7 24740015 2953876 Regulation FOXO1 TLR7 24740015 2954393 Regulation FOXO1 TLR8 24740015 2953877 Regulation FOXO1 TLR8 24740015 2954394 Regulation FOXO1 TLR9 24740015 2953878 Regulation FOXO1 TLR9 24740015 2954395 Regulation FOXO1 TMEM135 21151927 2485375 Regulation FOXO1 TNF 20300563 1910591 Regulation FOXO1 TNF 20300563 1910598 Regulation FOXO1 TNF 20300563 1910599 Regulation FOXO1 TNFRSF9 23874982 2823972 Regulation FOXO1 TNFSF11 24781012 1941808 Regulation FOXO1 TNFSF11 24781012 1941818 Regulation FOXO1 TNFSF13B 24801688 2961559 Regulation FOXO1 TP53 18665269 2394235 Regulation FOXO1 TP53 20085646 236523 Regulation FOXO1 TP53 24466179 2913880 Regulation FOXO1 TRG 21144036 1647921 Regulation FOXO1 TRIM54 22690213 1073164 Regulation FOXO1 TRIM63 23555761 2775265 Regulation FOXO1 TSC22D3 23516608 2768718 Regulation FOXO1 TSC22D3 23516608 2768722 Regulation FOXO1 TSC22D3 23516608 2768726 Regulation FOXO1 TSC22D3 23516608 2768729 Regulation FOXO1 UGCG 23154295 2110542 Regulation FOXO1 WAS 22156377 29999 Regulation FOXO1 WAS 22156377 30070 Regulation FOXO1 WAS 22156377 30080 Regulation FOXO1 WNT3A 24466091 2913272 Regulation FOXO1 XBP1 23277279 610798 Regulation FOXO1 XBP1 23277279 610799 Regulation FOXO1 XBP1 23277279 610845 Regulation FOXO1 XBP1 23277279 610865 Regulation FOXO1 XBP1 24683410 1226792 Regulation FOXO3 ALDH2 22524197 358549 Regulation FOXO3 EPHB2 20885957 2475706 Regulation FOXO3 EPHB2 22242005 2328443 Regulation FOXO3 EPHB2 25271153 1211021 Regulation FOXO3 FAS 15569384 382396 Regulation FOXO3 FBXO32 22586590 722921 Regulation FOXO3 FBXO32 22690213 1073170 Regulation FOXO3 FOXO1 21965295 1795334 Regulation FOXO3 FOXO1 23661003 561742 Regulation FOXO3 FOXO1 24757526 1491702 Regulation FOXO3 FOXO1 25546383 3036509 Regulation FOXO3 MAP2K6 20868529 1647814 Regulation FOXO3 PGC 24801481 2961424 Regulation FOXO3 SELL 22888331 903201 Regulation FOXO3 SELL 23183047 1570170 Regulation FOXO3 SPHK1 21625639 2525203 Regulation FOXO3 SPHK1 21625639 2525207 Regulation FOXO3 SPHK1 21625639 2525210 Regulation FOXO3 SPHK1 21625639 2525221 Regulation FOXO3 SPHK1 21625639 2525222 Regulation FOXO3 SPHK1 21625639 2525232 Regulation FOXO4 EPHB2 22242005 2328461 Regulation FOXO4 FBXO32 22690213 1073175 Regulation FOXO4 FOXO1 21965295 1795336 Regulation FOXO4 FOXO1 24757526 1491703 Regulation FOXO4 SELL 22888331 903206 Regulation FOXO4 SELL 23183047 1570201 Regulation FOXO6 EPHB2 22242005 2328413 Regulation FOXO6 FBXO32 22690213 1073160 Regulation FOXO6 FOXO1 21965295 1795329 Regulation FOXO6 PGC 23639108 213497 Regulation FOXO6 SELL 22888331 903199 Regulation FOXO6 SELL 23183047 1570144 Regulation FOXP3 FOXO1 20439537 1558146 Regulation FOXP3 FOXO1 20439537 1558158 Regulation FOXP3 FOXO1 22905034 903666 Regulation FOXP3 FOXO1 24595170 2930845 Regulation FOXP3 HBEGF 25264896 3010770 Regulation FOXP3 ITGAL 25108241 1621232 Regulation FOXP3 PLAU 23169000 1904605 Regulation FOXP3 PLAU 23169000 1904606 Regulation FOXP3 STAT4 22046502 1702838 Regulation FOXQ1 FOXC1 24987514 828597 Regulation FOXQ1 FOXC2 24987514 828598 Regulation FOXQ1 FOXL1 24987514 828599 Regulation FOXQ1 KDM3A 22581778 2075303 Regulation FOXQ1 KDM3A 22581778 2075304 Regulation FOXQ1 KDM3A 22581778 2075305 Regulation FOXQ1 KDM3A 22581778 2075310 Regulation FOXQ1 MBD2 22581778 2075306 Regulation FPR2 EPHB2 23434665 1101991 Regulation FSHB FOXO1 25423188 3030057 Regulation FSHB FOXO1 25423188 3030070 Regulation FST MSX1 23316168 960734 Regulation FSTL1 TNF 24347831 1755754 Regulation FTH1 TNF 15296517 350525 Regulation FUT1 HBEGF 22330337 1717968 Regulation FUT1 HBEGF 22330337 1717974 Regulation FUT1 ITGAL 24749071 3166657 Regulation FUT1 TLR7 20706677 979163 Regulation FUT1 TLR7 20706677 979217 Regulation FUT1 TNF 11581316 1521094 Regulation FUT1 TNF 11581316 1521103 Regulation FUT1 TNF 21768269 1564321 Regulation FUT1 TNF 21768269 1564322 Regulation FUT1 TNF 23755201 2801920 Regulation FUT1 TNF 23882270 908329 Regulation FUT1 TNF 23882270 908331 Regulation FUT4 ABO 22157667 1734725 Regulation FUT4 FUT9 19048108 2401583 Regulation FUT4 HNF1A 21203500 2320887 Regulation FUT4 HNF1A 24069312 2852705 Regulation FUT4 HNF4A 21203500 2320888 Regulation FUT4 ME2 19707466 175873 Regulation FXN PGC 19376812 1032232 Regulation FYN EPHB2 23874979 2823945 Regulation FZD4 MPZ 21752258 1892311 Regulation FZD4 MYLIP 25018733 965454 Regulation FZD4 SLC9A3R1 20802536 2135841 Regulation FZD4 SLC9A3R1 20802536 2135842 Regulation FZD4 WNT1 17386109 279570 Regulation FZD4 WNT1 17386109 279585 Regulation FZD4 WNT1 22019198 2252948 Regulation FZD4 WNT11 17386109 279571 Regulation FZD4 WNT11 17386109 279586 Regulation FZD4 WNT11 22019198 2252949 Regulation FZD4 WNT16 17386109 279577 Regulation FZD4 WNT16 17386109 279591 Regulation FZD4 WNT16 22019198 2252954 Regulation FZD4 WNT2 17386109 279572 Regulation FZD4 WNT2 17386109 279573 Regulation FZD4 WNT2 17386109 279587 Regulation FZD4 WNT2 17386109 279593 Regulation FZD4 WNT2 22019198 2252950 Regulation FZD4 WNT3 17386109 279574 Regulation FZD4 WNT3 17386109 279588 Regulation FZD4 WNT3 22019198 2252951 Regulation FZD4 WNT4 17386109 279575 Regulation FZD4 WNT4 17386109 279589 Regulation FZD4 WNT4 22019198 2252952 Regulation FZD4 WNT6 17386109 279576 Regulation FZD4 WNT6 17386109 279590 Regulation FZD4 WNT6 22019198 2252953 Regulation G0S2 INS 23951308 2834127 Regulation G6PC EPHB2 22848439 2669014 Regulation G6PC FAS 22676303 1724591 Regulation G6PC FOXO1 21559261 3128191 Regulation G6PC FOXO1 21804540 1961585 Regulation G6PC FOXO1 22291689 923969 Regulation G6PC FOXO1 22848439 2669010 Regulation G6PC FOXO1 25136826 2998922 Regulation G6PD TP63 23811687 1929245 Regulation GAB1 PECAM1 20723025 1692082 Regulation GAB1 PECAM1 20723025 1692116 Regulation GAB2 EPHB2 19737390 526018 Regulation GAB3 CD2 7561741 1612485 Regulation GAB3 CD2 7561741 1612489 Regulation GAB3 SHC1 23607741 536051 Regulation GABPA EPHB2 24839356 1758779 Regulation GABPA EPHB2 25353254 1731135 Regulation GABPA LBP 24400114 2905761 Regulation GABPA MAP2K6 22530035 2621003 Regulation GABPA PGC 22072942 1091855 Regulation GADD45A DAPK1 24216985 500739 Regulation GADD45A EPHB2 21286247 1028305 Regulation GADD45A FOXO1 24436017 494509 Regulation GADD45A FOXO1 24710551 619624 Regulation GADD45A MAP2K6 21286247 1028319 Regulation GADD45A MAP2K6 21286247 1028320 Regulation GADD45B TNF 21738489 2325079 Regulation GAL GNE 20383336 2445909 Regulation GAL TLR7 23202469 3221712 Regulation GAPDH EPHB2 22964641 2148624 Regulation GAPDH EPHB2 24990076 742257 Regulation GAST CCND1 15798764 425452 Regulation GAST TNF 7502522 3230090 Regulation GATA1 FOXO1 23271974 2340571 Regulation GATA1 MAP2K6 23717580 2798266 Regulation GATA2 FHL1 19075112 1362572 Regulation GATA2 FOXO1 23271974 2340575 Regulation GATA3 FOXA1 16643655 319059 Regulation GATA3 FOXO1 23271974 2340579 Regulation GATA3 STAT4 23345540 2209522 Regulation GATA4 EPHB2 21702924 508506 Regulation GATA4 EPHB2 21702924 508562 Regulation GATA4 FOXO1 23271974 2340583 Regulation GATA4 MAP2K6 21702924 508512 Regulation GATA4 MAP2K6 21702924 508568 Regulation GATA4 MSX1 23620817 2783521 Regulation GATA5 FOXO1 23271974 2340567 Regulation GATA6 FOXO1 23271974 2340587 Regulation GBP1 EPHB2 22692453 1918831 Regulation GCG FOXA1 17907808 2304411 Regulation GCG FOXO1 21283589 2496906 Regulation GCG GLP1R 23649520 727268 Regulation GCG TSPAN1 23840313 2812598 Regulation GEMIN2 CAPN8 21209906 2492075 Regulation GEMIN2 SMN2 21124729 2319950 Regulation GEMIN4 CAPN8 21209906 2492131 Regulation GEMIN4 SMN2 21124729 2319958 Regulation GEMIN5 CAPN8 21209906 2492145 Regulation GEMIN5 SMN2 21124729 2319962 Regulation GEMIN6 CAPN8 21209906 2492159 Regulation GEMIN6 SMN2 21124729 2319965 Regulation GEMIN7 CAPN8 21209906 2492173 Regulation GEMIN7 SMN2 21124729 2319968 Regulation GEMIN8 SMN2 21124729 2319971 Regulation GFAP CTGF 22511849 1914263 Regulation GFAP LBP 23517687 294296 Regulation GFAP MMP28 22438979 2612540 Regulation GFAP MMP7 22438979 2612555 Regulation GFAP TNF 24008729 565519 Regulation GFAP TNF 25025494 2989212 Regulation GFAP WNT7A 25170755 3003855 Regulation GH1 RASD1 24817889 1070764 Regulation GIF TNF 18474096 110755 Regulation GIF TNF 19088872 2219129 Regulation GIP GLP1R 20215429 713029 Regulation GJA1 MAP2K6 21738714 2533506 Regulation GJA1 MAP2K6 24002703 1880147 Regulation GJA1 MMP28 24002703 1880140 Regulation GJA1 MMP7 24002703 1880164 Regulation GJA1 TNF 22590660 2371275 Regulation GJB2 CA2 20584891 1609778 Regulation GJB2 DSC1 24931423 1681429 Regulation GJB2 DSC2 24931423 1681430 Regulation GJB2 DSC3 24931423 1681431 Regulation GJB2 FLI1 21647307 3128214 Regulation GJB2 KDM5B 23579952 1105440 Regulation GJB2 KDM5B 23579952 1105446 Regulation GJB2 MBD2 23579952 1105441 Regulation GJB2 MT-CO2 24847209 869326 Regulation GJB2 POU3F4 25259580 3010473 Regulation GJB4 DSC1 24931423 1681435 Regulation GJB4 DSC2 24931423 1681436 Regulation GJB4 DSC3 24931423 1681437 Regulation GJC1 MAP2K6 11514593 1273973 Regulation GJC2 MAP2K6 11514593 1273955 Regulation GJC3 MAP2K6 11514593 1273964 Regulation GLI1 EPHB2 21860067 2176456 Regulation GLI1 EPHB2 23097684 2181610 Regulation GLI1 EPHB2 23900341 2183758 Regulation GLI1 MAP2K6 20941789 775428 Regulation GLI1 MAP2K6 21860067 2176462 Regulation GLI1 MAP2K6 23097684 2181616 Regulation GLI1 MAP2K6 23436775 780192 Regulation GLI1 MAP2K6 23900341 2183764 Regulation GLI1 MAP2K6 23935925 2828461 Regulation GLI1 MAP2K6 24852887 3157740 Regulation GLI1 TLR7 23995793 2153498 Regulation GLI2 MAP2K6 24852887 3157776 Regulation GLI2 TNF 25009639 844850 Regulation GLI2 TNF 25009639 844851 Regulation GLP1R INS 21747829 831783 Regulation GLP1R ISL1 23518338 699067 Regulation GLP1R NPAS4 23656887 727308 Regulation GLP1R PDX1 18544709 706253 Regulation GLP1R ZGLP1 19859570 1213165 Regulation GLP1R ZGLP1 21430088 718900 Regulation GLP1R ZGLP1 21744074 733473 Regulation GLP1R ZGLP1 24327600 787522 Regulation GLS EPHB2 21085672 2483044 Regulation GLS TNF 22534375 125585 Regulation GLS TNF 22534375 125587 Regulation GLS TNF 22534375 125589 Regulation GNB1 RGS2 23755177 2801654 Regulation GNB2L1 TNF 20352103 2444813 Regulation GNE LDHB 18560563 2391312 Regulation GNG10 FAS 22676303 1724592 Regulation GNG10 FAS 22676303 1724655 Regulation GNG10 FAS 22676303 1724656 Regulation GNG11 FAS 22676303 1724593 Regulation GNG11 FAS 22676303 1724657 Regulation GNG11 FAS 22676303 1724658 Regulation GNG12 FAS 22676303 1724589 Regulation GNG12 FAS 22676303 1724651 Regulation GNG12 FAS 22676303 1724652 Regulation GNG13 FAS 22676303 1724588 Regulation GNG13 FAS 22676303 1724649 Regulation GNG13 FAS 22676303 1724650 Regulation GNG2 FAS 22676303 1724594 Regulation GNG2 FAS 22676303 1724659 Regulation GNG2 FAS 22676303 1724660 Regulation GNG2 RGS2 23755177 2801655 Regulation GNG3 FAS 22676303 1724595 Regulation GNG3 FAS 22676303 1724661 Regulation GNG3 FAS 22676303 1724662 Regulation GNG4 FAS 22676303 1724596 Regulation GNG4 FAS 22676303 1724663 Regulation GNG4 FAS 22676303 1724664 Regulation GNG5 FAS 22676303 1724597 Regulation GNG5 FAS 22676303 1724665 Regulation GNG5 FAS 22676303 1724666 Regulation GNG7 FAS 22676303 1724598 Regulation GNG7 FAS 22676303 1724667 Regulation GNG7 FAS 22676303 1724668 Regulation GNG8 FAS 22676303 1724590 Regulation GNG8 FAS 22676303 1724653 Regulation GNG8 FAS 22676303 1724654 Regulation GNRH1 LBP 24454506 825097 Regulation GNRHR EPHB2 23248618 877650 Regulation GOLGA2 EPHB2 11425867 1271714 Regulation GOLGA2 RAB31 11927603 1280563 Regulation GOLGB1 RAB31 11927603 1280591 Regulation GORASP1 EPHB2 18762583 1357040 Regulation GORASP1 EPHB2 18762583 1357062 Regulation GORASP1 MAP2K6 18762583 1357068 Regulation GOT2 FAS 23382926 2746805 Regulation GP2 ITGAL 16445864 3096164 Regulation GP2 ITGB2 16445864 3096165 Regulation GP2 ITGB2 2564418 1577423 Regulation GP2 TNF 22837985 940970 Regulation GP2 TNF 23853427 1754080 Regulation GP5 ITGAL 16445864 3096166 Regulation GP5 ITGB2 16445864 3096167 Regulation GP5 ITGB2 2564418 1577425 Regulation GP5 TNF 22837985 940972 Regulation GP5 TNF 23853427 1754082 Regulation GP6 ITGAL 16445864 3096162 Regulation GP6 ITGB2 16445864 3096163 Regulation GP6 ITGB2 2564418 1577421 Regulation GP6 PECAM1 19850043 850763 Regulation GP6 TNF 22837985 940968 Regulation GP6 TNF 23853427 1754078 Regulation GP9 ITGAL 16445864 3096168 Regulation GP9 ITGB2 16445864 3096169 Regulation GP9 ITGB2 2564418 1577427 Regulation GP9 TNF 22837985 940974 Regulation GP9 TNF 23853427 1754084 Regulation GPER1 FAS 21203528 2490696 Regulation GPHN EPHB2 24782709 869151 Regulation GPI EPHB2 23785474 2806388 Regulation GPI EPHB2 24385109 1880240 Regulation GPI SLC9A2 20011065 1213390 Regulation GPI TNF 23755184 2801850 Regulation GPNMB FLCN 21209915 2492402 Regulation GPNMB FLCN 21209915 2492447 Regulation GPNMB FLCN 21209915 2492449 Regulation GPNMB MITF 22912767 2679227 Regulation GPNMB MITF 22912767 2679233 Regulation GPNMB MMP1 20711474 2471244 Regulation GPNMB MMP10 20711474 2471245 Regulation GPNMB MMP11 20711474 2471246 Regulation GPNMB MMP12 20711474 2471247 Regulation GPNMB MMP13 20711474 2471248 Regulation GPNMB MMP14 20711474 2471249 Regulation GPNMB MMP15 20711474 2471250 Regulation GPNMB MMP16 20711474 2471251 Regulation GPNMB MMP17 20711474 2471252 Regulation GPNMB MMP19 20711474 2471253 Regulation GPNMB MMP2 20711474 2471254 Regulation GPNMB MMP20 20711474 2471255 Regulation GPNMB MMP21 20711474 2471242 Regulation GPNMB MMP24 20711474 2471256 Regulation GPNMB MMP25 20711474 2471239 Regulation GPNMB MMP26 20711474 2471240 Regulation GPNMB MMP27 20711474 2471241 Regulation GPNMB MMP28 20711474 2471243 Regulation GPNMB MMP3 20711474 2471257 Regulation GPNMB MMP7 20711474 2471258 Regulation GPNMB MMP8 20711474 2471259 Regulation GPNMB MMP9 20711474 2471260 Regulation GPNMB SOD1 22891158 3131106 Regulation GPNMB TCF12 22912767 2679216 Regulation GPNMB TCF15 22912767 2679217 Regulation GPNMB TCF19 22912767 2679218 Regulation GPNMB TCF20 22912767 2679219 Regulation GPNMB TCF21 22912767 2679220 Regulation GPNMB TCF23 22912767 2679224 Regulation GPNMB TCF24 22912767 2679226 Regulation GPNMB TCF25 22912767 2679225 Regulation GPNMB TCF3 22912767 2679221 Regulation GPNMB TCF4 22912767 2679222 Regulation GPNMB TCF7 22912767 2679223 Regulation GPNMB TFE3 21209915 2492400 Regulation GPNMB TFE3 21209915 2492401 Regulation GPNMB TFE3 21209915 2492446 Regulation GPNMB TFE3 21209915 2492448 Regulation GPR115 CA2 17362227 1691966 Regulation GPR115 GPR64 23226635 1044274 Regulation GPR115 MTOR 25295009 966168 Regulation GPR115 QRICH1 24339877 2893272 Regulation GPR115 QRICH2 24339877 2893273 Regulation GPR115 RAB4A 24785348 619896 Regulation GPR115 RASGRF1 11134081 1266390 Regulation GPR115 RASGRF2 11134081 1266391 Regulation GPR115 RGS5 17315600 3208291 Regulation GPR115 RHO 22375118 950863 Regulation GPR115 RIC8A 19432969 362196 Regulation GPR115 SAA1 22731103 1663760 Regulation GPR115 SRC 23887203 144582 Regulation GPR115 WNT1 24339877 2893265 Regulation GPR115 WNT11 24339877 2893266 Regulation GPR115 WNT16 24339877 2893271 Regulation GPR115 WNT2 24339877 2893267 Regulation GPR115 WNT3 24339877 2893268 Regulation GPR115 WNT4 24339877 2893269 Regulation GPR115 WNT6 24339877 2893270 Regulation GPR132 CA2 17362227 1691955 Regulation GPR132 GPR64 23226635 1044263 Regulation GPR132 MTOR 25295009 966157 Regulation GPR132 QRICH1 24339877 2893173 Regulation GPR132 QRICH2 24339877 2893174 Regulation GPR132 RAB4A 24785348 619885 Regulation GPR132 RASGRF1 11134081 1266368 Regulation GPR132 RASGRF2 11134081 1266369 Regulation GPR132 RGS5 17315600 3208280 Regulation GPR132 RHO 22375118 950852 Regulation GPR132 RIC8A 19432969 362185 Regulation GPR132 SAA1 22731103 1663749 Regulation GPR132 SRC 23887203 144571 Regulation GPR132 WNT1 24339877 2893166 Regulation GPR132 WNT11 24339877 2893167 Regulation GPR132 WNT16 24339877 2893172 Regulation GPR132 WNT2 24339877 2893168 Regulation GPR132 WNT3 24339877 2893169 Regulation GPR132 WNT4 24339877 2893170 Regulation GPR132 WNT6 24339877 2893171 Regulation GPR87 CA2 17362227 1692035 Regulation GPR87 GPR64 23226635 1044343 Regulation GPR87 MTOR 25295009 966237 Regulation GPR87 QRICH1 24339877 2894093 Regulation GPR87 QRICH2 24339877 2894094 Regulation GPR87 RAB4A 24785348 619967 Regulation GPR87 RASGRF1 11134081 1266528 Regulation GPR87 RASGRF2 11134081 1266529 Regulation GPR87 RGS5 17315600 3208360 Regulation GPR87 RHO 22375118 950932 Regulation GPR87 RIC8A 19432969 362265 Regulation GPR87 SAA1 22731103 1663829 Regulation GPR87 SRC 23887203 144651 Regulation GPR87 TP53 22266725 14442 Regulation GPR87 WNT1 24339877 2894086 Regulation GPR87 WNT11 24339877 2894087 Regulation GPR87 WNT16 24339877 2894092 Regulation GPR87 WNT2 24339877 2894088 Regulation GPR87 WNT3 24339877 2894089 Regulation GPR87 WNT4 24339877 2894090 Regulation GPR87 WNT6 24339877 2894091 Regulation GPX1 LBP 21541044 1090768 Regulation GPX1 LBP 21541044 1090769 Regulation GPX1 OSR1 25206429 2004412 Regulation GPX1 PGC 22563483 2626886 Regulation GPX2 LBP 21541044 1090770 Regulation GPX2 LBP 21541044 1090771 Regulation GPX2 OSR1 25206429 2004414 Regulation GPX2 PGC 22563483 2626887 Regulation GPX3 LBP 21541044 1090772 Regulation GPX3 LBP 21541044 1090773 Regulation GPX3 OSR1 25206429 2004416 Regulation GPX3 PGC 22563483 2626888 Regulation GPX4 LBP 21541044 1090774 Regulation GPX4 LBP 21541044 1090775 Regulation GPX4 OSR1 25206429 2004418 Regulation GPX4 PGC 22563483 2626889 Regulation GPX5 LBP 21541044 1090776 Regulation GPX5 LBP 21541044 1090777 Regulation GPX5 OSR1 25206429 2004420 Regulation GPX5 PGC 22563483 2626890 Regulation GPX6 LBP 21541044 1090778 Regulation GPX6 LBP 21541044 1090779 Regulation GPX6 OSR1 25206429 2004422 Regulation GPX6 PGC 22563483 2626891 Regulation GPX7 LBP 21541044 1090780 Regulation GPX7 LBP 21541044 1090781 Regulation GPX7 OSR1 25206429 2004424 Regulation GPX7 PGC 22563483 2626892 Regulation GPX8 LBP 21541044 1090766 Regulation GPX8 LBP 21541044 1090767 Regulation GPX8 OSR1 25206429 2004410 Regulation GPX8 PGC 22563483 2626885 Regulation GRAP2 PECAM1 12177047 1286360 Regulation GRAP2 TNF 16207331 104366 Regulation GRAP2 TNF 24352036 1632453 Regulation GRB10 ITGAL 24114554 808864 Regulation GRB10 KCNE1 23183700 1610398 Regulation GRB14 ITGAL 24114554 808865 Regulation GRB14 KCNE1 23183700 1610399 Regulation GRB2 ITGAL 24114554 808866 Regulation GRB2 KCNE1 23183700 1610400 Regulation GRB7 ITGAL 24114554 808867 Regulation GRB7 KCNE1 23183700 1610401 Regulation GRIK2 NETO2 25141211 1766238 Regulation GRIK2 PRKACB 25141211 1766205 Regulation GRIK2 PRKACG 25141211 1766206 Regulation GRIK2 PRKAR1A 25141211 1766207 Regulation GRIK2 PRKAR1B 25141211 1766208 Regulation GRIK2 PRKAR2A 25141211 1766209 Regulation GRIK2 PRKAR2B 25141211 1766210 Regulation GRIK2 RAB17 24895134 1209565 Regulation GRIK2 RAB17 24895134 1209570 Regulation GRIK2 RAB4A 23556457 3187405 Regulation GRIK2 RAB8A 23556457 3187404 Regulation GRIK5 EPHB2 25500906 2160850 Regulation GRIN2D PLAT 21975018 1892491 Regulation GRK1 F2R 21760880 2535860 Regulation GRK4 F2R 21760880 2535862 Regulation GRK5 F2R 21760880 2535863 Regulation GRK6 F2R 21760880 2535864 Regulation GRK7 F2R 21760880 2535861 Regulation GSK3A EPHB2 20941790 775570 Regulation GSK3A MAP2K6 20941790 775576 Regulation GSK3B EPHB2 20941790 775578 Regulation GSK3B MAP2K6 20941790 775584 Regulation GSN SCIN 22676183 363466 Regulation GSPT1 CCND1 23383245 2749740 Regulation GSPT1 ID1 25028095 1875736 Regulation GSPT2 CCND1 23383245 2749744 Regulation GSTA4 EPHB2 24999379 2229499 Regulation GTF2B STK39 22303389 881852 Regulation GTF2F1 STK39 22303389 881867 Regulation GTF2F2 STK39 22303389 881882 Regulation GUCY2D S100B 24723847 931616 Regulation GYG1 PGC 22272266 2589500 Regulation GZMB MAP2K6 24795729 912627 Regulation GZMB TNF 23483844 863988 Regulation H2AFX TNF 19641621 2422118 Regulation H2AFX TNFSF10 21092294 1860279 Regulation HACE1 CCND1 23864022 1937161 Regulation HACE1 CCND1 23864022 1937162 Regulation HAMP TF 19107209 2402729 Regulation HAMP TF 20066043 21500 Regulation HAMP TF 20631898 21574 Regulation HAMP TF 23092063 153573 Regulation HAMP TF 24653703 953812 Regulation HAMP TNF 23505235 91340 Regulation HAMP TNF 24286116 130139 Regulation HAMP TNF 24286116 130140 Regulation HAMP TNF 24286116 130141 Regulation HAMP TNF 24286116 130142 Regulation HAMP TNF 24286116 130155 Regulation HAMP TNF 24286116 130156 Regulation HAMP TNF 24741293 176303 Regulation HAPLN1 EPHB2 19144181 112456 Regulation HAPLN1 MAP2K6 19144181 112462 Regulation HAS1 HAS3 23314337 453231 Regulation HAS2 MMP28 21708929 1564121 Regulation HAS2 MMP7 21708929 1564137 Regulation HAS3 IL10 21263749 806612 Regulation HAS3 IL11 21263749 806613 Regulation HAS3 IL13 21263749 806614 Regulation HAS3 IL15 21263749 806615 Regulation HAS3 IL16 21263749 806616 Regulation HAS3 IL18 21263749 806617 Regulation HAS3 IL19 21263749 806618 Regulation HAS3 IL2 21263749 806619 Regulation HAS3 IL20 21263749 806620 Regulation HAS3 IL21 21263749 806621 Regulation HAS3 IL22 21263749 806604 Regulation HAS3 IL24 21263749 806602 Regulation HAS3 IL25 21263749 806603 Regulation HAS3 IL26 21263749 806608 Regulation HAS3 IL27 21263749 806609 Regulation HAS3 IL3 21263749 806622 Regulation HAS3 IL31 21263749 806610 Regulation HAS3 IL32 21263749 806607 Regulation HAS3 IL33 21263749 806606 Regulation HAS3 IL34 21263749 806611 Regulation HAS3 IL37 21263749 806605 Regulation HAS3 IL4 21263749 806623 Regulation HAS3 IL5 21263749 806624 Regulation HAS3 IL6 21263749 806625 Regulation HAS3 IL7 21263749 806626 Regulation HAS3 IL8 21263749 806627 Regulation HAS3 IL9 21263749 806628 Regulation HAVCR2 TLR7 24339828 910258 Regulation HBA1 HES2 24825971 1162804 Regulation HBD SPHK1 20634980 2455680 Regulation HBD TNF 23649937 161222 Regulation HBD TNF 23762096 637766 Regulation HBEGF ADAM10 23888518 3185291 Regulation HBEGF ADAM11 23888518 3185292 Regulation HBEGF ADAM12 23589494 1404539 Regulation HBEGF ADAM12 23888518 3185293 Regulation HBEGF ADAM15 14993236 1306910 Regulation HBEGF ADAM15 23888518 3185294 Regulation HBEGF ADAM17 23888518 3185295 Regulation HBEGF ADAM18 23888518 3185296 Regulation HBEGF ADAM19 23888518 3185297 Regulation HBEGF ADAM2 23888518 3185298 Regulation HBEGF ADAM20 23888518 3185299 Regulation HBEGF ADAM21 23888518 3185300 Regulation HBEGF ADAM22 23888518 3185301 Regulation HBEGF ADAM23 23888518 3185302 Regulation HBEGF ADAM28 23888518 3185303 Regulation HBEGF ADAM29 23888518 3185304 Regulation HBEGF ADAM30 23888518 3185305 Regulation HBEGF ADAM32 23888518 3185290 Regulation HBEGF ADAM33 23888518 3185289 Regulation HBEGF ADAM5 23888518 3185306 Regulation HBEGF ADAM6 23888518 3185307 Regulation HBEGF ADAM7 23888518 3185308 Regulation HBEGF ADAM8 23888518 3185309 Regulation HBEGF ADAM9 23888518 3185310 Regulation HBEGF AKT1 22984591 2689349 Regulation HBEGF AKT2 22984591 2689350 Regulation HBEGF AKT3 22984591 2689351 Regulation HBEGF BACE2 7790364 1441076 Regulation HBEGF CCK 20584780 1023287 Regulation HBEGF CD9 10662783 1255858 Regulation HBEGF CD9 10662783 1255864 Regulation HBEGF CD9 7790364 1441075 Regulation HBEGF CSF2 25033458 2990303 Regulation HBEGF EDN1 20452970 1187764 Regulation HBEGF EGF 23029355 2696806 Regulation HBEGF EGFR 25033458 2990299 Regulation HBEGF F12 17177600 2368928 Regulation HBEGF GAST 20584780 1023271 Regulation HBEGF GAST PMC2557557 450135 Regulation HBEGF IL1A 22911722 2675967 Regulation HBEGF IL1A 22911722 2675969 Regulation HBEGF IL1A 22911722 2675972 Regulation HBEGF IL1A 22911722 2675973 Regulation HBEGF IL1A 22911722 2675975 Regulation HBEGF MMP1 23213380 167791 Regulation HBEGF MMP1 23213380 167880 Regulation HBEGF MMP10 23213380 167792 Regulation HBEGF MMP10 23213380 167881 Regulation HBEGF MMP11 23213380 167793 Regulation HBEGF MMP11 23213380 167882 Regulation HBEGF MMP12 23213380 167794 Regulation HBEGF MMP12 23213380 167883 Regulation HBEGF MMP13 23213380 167795 Regulation HBEGF MMP13 23213380 167884 Regulation HBEGF MMP14 23213380 167796 Regulation HBEGF MMP14 23213380 167885 Regulation HBEGF MMP15 23213380 167797 Regulation HBEGF MMP15 23213380 167886 Regulation HBEGF MMP16 23213380 167798 Regulation HBEGF MMP16 23213380 167887 Regulation HBEGF MMP17 23213380 167799 Regulation HBEGF MMP17 23213380 167888 Regulation HBEGF MMP19 23213380 167800 Regulation HBEGF MMP19 23213380 167889 Regulation HBEGF MMP2 23213380 167801 Regulation HBEGF MMP2 23213380 167890 Regulation HBEGF MMP20 23213380 167802 Regulation HBEGF MMP20 23213380 167891 Regulation HBEGF MMP21 23213380 167789 Regulation HBEGF MMP21 23213380 167878 Regulation HBEGF MMP24 23213380 167803 Regulation HBEGF MMP24 23213380 167892 Regulation HBEGF MMP25 23213380 167786 Regulation HBEGF MMP25 23213380 167875 Regulation HBEGF MMP26 23213380 167787 Regulation HBEGF MMP26 23213380 167876 Regulation HBEGF MMP27 23213380 167788 Regulation HBEGF MMP27 23213380 167877 Regulation HBEGF MMP28 23213380 167790 Regulation HBEGF MMP28 23213380 167879 Regulation HBEGF MMP3 23213380 167804 Regulation HBEGF MMP3 23213380 167893 Regulation HBEGF MMP7 23213380 167805 Regulation HBEGF MMP7 23213380 167894 Regulation HBEGF MMP8 23213380 167806 Regulation HBEGF MMP8 23213380 167895 Regulation HBEGF MMP9 23213380 167807 Regulation HBEGF MMP9 23213380 167896 Regulation HBEGF MYLIP 22319602 2595597 Regulation HBEGF MYLIP 22319602 2595601 Regulation HBEGF OXA1L 22319602 2595598 Regulation HBEGF PSEN1 14597771 1299850 Regulation HBEGF RUNX2 24136232 568210 Regulation HBEGF RUNX2 24136232 568211 Regulation HBEGF RUNX2 24136232 568212 Regulation HBEGF RUNX2 24136232 568224 Regulation HBEGF SDC2 8349739 1447592 Regulation HBEGF SLC33A1 23451083 2757721 Regulation HBEGF SP1 25060396 492932 Regulation HBEGF SRC 23209895 1689855 Regulation HBEGF SRC 23213380 167784 Regulation HBEGF SRC 23213380 167785 Regulation HBEGF SRC 25342939 685344 Regulation HBEGF TLR2 21124967 2484842 Regulation HBEGF TLR4 21124967 2484843 Regulation HCCS CCND1 19402906 1503677 Regulation HCK TNF 25332099 607571 Regulation HDAC3 RCAN1 25144594 3001078 Regulation HDAC3 TNF 24039666 2844445 Regulation HDAC4 IL1B 25424126 133930 Regulation HDAC6 EPHB2 24023871 2843892 Regulation HES1 MAP2K6 24392017 2905179 Regulation HES1 TNF 22190977 633831 Regulation HES2 DCC 24009732 2841426 Regulation HES2 MYLIP 24945987 2300931 Regulation HES2 NOTCH1 24086596 2854948 Regulation HES2 NOTCH2 24086596 2854949 Regulation HES2 NOTCH3 23028706 2692642 Regulation HES2 NOTCH3 24086596 2854950 Regulation HES2 NOTCH4 24086596 2854951 Regulation HGF PLAU 11953898 421605 Regulation HGF PLAU 17134505 312983 Regulation HGF TNF 20551596 3078654 Regulation HGF TNF 25099287 3144951 Regulation HGF TNFSF10 18992144 251792 Regulation HHIP PDZK1 21653824 1791346 Regulation HHIP PDZK1 21653824 1791347 Regulation HHIP PDZK1 21653824 1791348 Regulation HHIP PDZK1 21653824 1791360 Regulation HIF1A IL1B 12378005 1633013 Regulation HIF1A TNF 12378005 1633007 Regulation HIGD1A JAG1 23115560 968866 Regulation HIST1H3H EGLN3 20677832 156742 Regulation HIST1H3H UCA1 24876127 758402 Regulation HIST1H3J STK39 25521508 2367704 Regulation HIST1H4E FOXA1 21623366 1976274 Regulation HIST2H3C ITGAL 17325197 1544510 Regulation HIVEP3 TNF 25228904 914162 Regulation HK1 CDKN1C 22592318 555551 Regulation HK1 EPHB2 21085672 2483207 Regulation HK2 EPHB2 21085672 2483211 Regulation HK2 EPHB2 23118219 1205519 Regulation HK2 PGC 19696889 2310531 Regulation HK3 EPHB2 21085672 2483215 Regulation HLA-DRA TLR7 18509450 2389688 Regulation HLA-DRA TLR7 21587207 769715 Regulation HLA-DRB1 EPHB2 22662193 2647203 Regulation HLA-DRB1 MAP2K6 22892844 478765 Regulation HLA-DRB1 TLR7 18509450 2389698 Regulation HLA-DRB1 TLR7 21587207 769725 Regulation HLA-DRB1 TNFSF10 21209944 2492478 Regulation HLA-DRB1 TNFSF10 22495350 555330 Regulation HLA-DRB1 TNFSF10 23432760 267893 Regulation HLA-DRB1 TNFSF10 24287697 569443 Regulation HLA-DRB1 TNFSF10 25015549 2195774 Regulation HLA-DRB1 TNFSF10 25015549 2195791 Regulation HLA-E TNF 21712991 2531483 Regulation HLA-E TNF 24236107 2878566 Regulation HMGB1 EPHB2 23392177 559857 Regulation HMGB1 EPHB2 25019241 1943131 Regulation HMGB1 TNF 16354107 2368639 Regulation HMGB1 TNF 18346273 110179 Regulation HMGB1 TNF 18346273 110183 Regulation HMGB1 TNF 18557992 110960 Regulation HMGB1 TNF 21406085 313380 Regulation HMGB1 TNF 21871094 123921 Regulation HMGB1 TNF 23349558 6676 Regulation HMGB1 TNF 23403473 842969 Regulation HMGB1 TNF 23738324 181976 Regulation HMGCS2 FOXA1 22238690 2587080 Regulation HMOX1 BPI 19272177 1227022 Regulation HMOX1 EPHB2 21765607 1490007 Regulation HMOX1 EPHB2 23762139 820010 Regulation HMOX1 EPHB2 23762139 820026 Regulation HMOX1 EPHB2 23826208 2811440 Regulation HMOX1 EPHB2 23826208 2811512 Regulation HMOX1 EPHB2 24839356 1758785 Regulation HMOX1 EPHB2 24862327 680617 Regulation HMOX1 EPHB2 24958265 1767367 Regulation HMOX1 F2R 22541814 125604 Regulation HMOX1 F2R 22541814 125619 Regulation HMOX1 FOXO1 24255720 2882048 Regulation HMOX1 FOXO1 24255720 2882049 Regulation HMOX1 FOXO1 24255720 2882054 Regulation HMOX1 GLP1R 20364157 9800 Regulation HMOX1 GLP1R 20364157 9801 Regulation HMOX1 GLP1R 20364157 9815 Regulation HMOX1 LBP 24400114 2905762 Regulation HMOX1 PGC 24350287 185933 Regulation HMOX1 TNF 21307400 2174861 Regulation HMOX1 TNF 23285041 2732019 Regulation HMOX1 TNF 24013271 2842024 Regulation HMOX1 TNF 24212776 498330 Regulation HMOX1 TNF 24456852 2233577 Regulation HMOX1 TNF 24755677 2957240 Regulation HNF1A EPHB2 21283735 2497452 Regulation HNF1A MAP2K6 21283735 2497461 Regulation HNF4A CCND1 22751438 541615 Regulation HNF4A CCND1 22751438 541618 Regulation HNRNPA1 RNASE1 19656952 2047028 Regulation HNRNPD LAMB3 22160594 1798634 Regulation HNRNPD RAB31 18060067 2381222 Regulation HNRNPF ARSA 18411340 1550472 Regulation HNRNPF CCL17 24701375 2163130 Regulation HNRNPF EDN2 18195069 1548353 Regulation HNRNPF EDN2 18195069 1548441 Regulation HNRNPF EPHB2 25111504 2996291 Regulation HNRNPF ITGAL 21980488 2560948 Regulation HNRNPF ITGB2 22238634 2586764 Regulation HNRNPF ITGB2 22238634 2586765 Regulation HNRNPF MAP2K6 21544193 2517145 Regulation HNRNPF NT5E 23520507 2768963 Regulation HNRNPF STAT4 20231889 2443098 Regulation HNRNPF TLR7 12045249 1523546 Regulation HNRNPF TLR7 18086320 109693 Regulation HNRNPF TLR7 19476613 113392 Regulation HNRNPF TLR7 19476613 113400 Regulation HNRNPF TLR7 19557165 3044281 Regulation HNRNPF TLR7 20617179 3047913 Regulation HNRNPF TLR7 22125457 3152206 Regulation HNRNPF TLR7 22190970 633707 Regulation HNRNPF TLR7 22474436 980121 Regulation HNRNPF TLR7 22905233 2675775 Regulation HNRNPF TLR7 22984435 2688611 Regulation HNRNPF TLR7 24204367 909813 Regulation HNRNPF TLR7 24335833 1736633 Regulation HNRNPF TLR7 24705920 2949302 Regulation HNRNPF TLR7 25093822 2995307 Regulation HNRNPF TLR7 25153703 3002312 Regulation HNRNPF TLR7 25153703 3002369 Regulation HNRNPF TLR7 25429207 3216558 Regulation HNRNPF TNF 12823847 99842 Regulation HNRNPF TNF 19715582 353117 Regulation HNRNPF TNF 25123797 368556 Regulation HNRNPH1 ARSA 18411340 1550473 Regulation HNRNPH1 CCL17 24701375 2163132 Regulation HNRNPH1 EDN2 18195069 1548356 Regulation HNRNPH1 EDN2 18195069 1548444 Regulation HNRNPH1 EPHB2 25111504 2996292 Regulation HNRNPH1 ITGAL 21980488 2560949 Regulation HNRNPH1 ITGB2 22238634 2586766 Regulation HNRNPH1 ITGB2 22238634 2586767 Regulation HNRNPH1 MAP2K6 21544193 2517147 Regulation HNRNPH1 NT5E 23520507 2768964 Regulation HNRNPH1 STAT4 20231889 2443102 Regulation HNRNPH1 TLR7 12045249 1523547 Regulation HNRNPH1 TLR7 18086320 109703 Regulation HNRNPH1 TLR7 19476613 113393 Regulation HNRNPH1 TLR7 19476613 113401 Regulation HNRNPH1 TLR7 19557165 3044291 Regulation HNRNPH1 TLR7 20617179 3047923 Regulation HNRNPH1 TLR7 22125457 3152216 Regulation HNRNPH1 TLR7 22190970 633717 Regulation HNRNPH1 TLR7 22474436 980131 Regulation HNRNPH1 TLR7 22905233 2675785 Regulation HNRNPH1 TLR7 22984435 2688621 Regulation HNRNPH1 TLR7 24204367 909823 Regulation HNRNPH1 TLR7 24335833 1736644 Regulation HNRNPH1 TLR7 24705920 2949312 Regulation HNRNPH1 TLR7 25093822 2995309 Regulation HNRNPH1 TLR7 25153703 3002322 Regulation HNRNPH1 TLR7 25153703 3002379 Regulation HNRNPH1 TLR7 25429207 3216568 Regulation HNRNPH1 TNF 12823847 99843 Regulation HNRNPH1 TNF 19715582 353119 Regulation HNRNPH1 TNF 25123797 368558 Regulation HNRNPK ANGPT1 24642125 614216 Regulation HNRNPR SMN2 23383159 2748573 Regulation HNRNPR SMN2 25338097 3018568 Regulation HOXA2 MSX1 23316168 960741 Regulation HOXA5 PLAU 23864708 1816980 Regulation HOXA5 PLAU 23864708 1817027 Regulation HOXA5 PLAU 23864708 1817032 Regulation HOXB13 FOXA1 25206306 2249926 Regulation HOXB13 HOXB2 20504375 1855528 Regulation HOXB2 EGR2 8922394 1457849 Regulation HOXB2 HOXB1 23408898 2342534 Regulation HOXD-AS1 EPHB2 25522241 349990 Regulation HP TNF 9792335 1763848 Regulation HRAS DGKI 25233099 3008241 Regulation HRAS DGKI 25233099 3008248 Regulation HRAS EPHB2 17449939 1634819 Regulation HRAS EPHB2 18597688 251136 Regulation HRAS EPHB2 18629230 1212682 Regulation HRAS EPHB2 25003010 3092921 Regulation HRAS FOXO1 20375467 27030 Regulation HRAS FOXO1 23306151 1100400 Regulation HRAS FOXO1 24265619 962923 Regulation HRAS LGALS7B 23530091 2182840 Regulation HRAS LIPG 17967061 3039966 Regulation HRAS MAP2K6 18629230 1212688 Regulation HRAS STK39 24849659 2972583 Regulation HRAS TNF 25526565 1136161 Regulation HRH1 HRH4 22272324 2589579 Regulation HRH1 HSPB8 19259415 488866 Regulation HRH1 MAP2K1 23209876 3131746 Regulation HRH1 MAP2K2 23209876 3131747 Regulation HRH1 MAP2K3 23209876 3131748 Regulation HRH1 MAP2K4 23209876 3131749 Regulation HRH1 MAP2K5 23209876 3131750 Regulation HRH1 MAP2K6 23209876 3131751 Regulation HRH1 MAP2K7 23209876 3131752 Regulation HRH1 OFC1 20981231 1031559 Regulation HRH1 PARP1 23209876 3131745 Regulation HRH1 TRPC6 24709960 618011 Regulation HRH1 XRCC5 23209876 3131744 Regulation HRH1 XRCC5 23209876 3131765 Regulation HSD11B2 CEBPA 25133511 2998615 Regulation HSD11B2 CEBPB 25133511 2998616 Regulation HSD11B2 INS 25133511 2998617 Regulation HSD11B2 MAPK1 25229504 3008062 Regulation HSD11B2 MAPK10 25229504 3008063 Regulation HSD11B2 MAPK11 25229504 3008064 Regulation HSD11B2 MAPK12 25229504 3008065 Regulation HSD11B2 MAPK13 25229504 3008066 Regulation HSD11B2 MAPK14 25229504 3008067 Regulation HSD11B2 MAPK15 25229504 3008061 Regulation HSD11B2 MAPK3 25229504 3008068 Regulation HSD11B2 MAPK4 25229504 3008069 Regulation HSD11B2 MAPK6 25229504 3008070 Regulation HSD11B2 MAPK7 25229504 3008071 Regulation HSD11B2 MAPK8 25229504 3008072 Regulation HSD11B2 MAPK9 25229504 3008073 Regulation HSD11B2 SP1 25229504 3008046 Regulation HSD17B12 GRIK2 23556457 3187401 Regulation HSF1 CLU 25138053 2198208 Regulation HSF1 CLU 25138053 2198213 Regulation HSF1 EPHB2 23185570 2721943 Regulation HSF1 FOXO1 24314125 33291 Regulation HSP90AA1 CAPN8 23425388 275929 Regulation HSP90AA1 ETV7 22291956 2591381 Regulation HSP90AA1 ZFP57 25032857 577565 Regulation HSP90AB1 CAPN8 18200806 3208536 Regulation HSPA5 CAPN8 22069639 3182998 Regulation HSPA5 CLU 23457489 2758637 Regulation HSPA5 CLU 23457489 2758645 Regulation HSPA5 TNFSF10 24795528 1062775 Regulation HSPB1 CLU 25138053 2198210 Regulation HSPB1 TNF 18519735 1352449 Regulation HSPB3 PLAT 18389070 631105 Regulation HSPB3 ZBTB16 17973985 1002955 Regulation HSPB8 HRH1 19259415 488865 Regulation HSPG2 GPR115 15847696 1896606 Regulation HSPG2 GPR132 15847696 1896595 Regulation HSPG2 GPR87 15847696 1896675 Regulation HTN1 CD14 24473528 3139669 Regulation HTN3 CD14 24473528 3139670 Regulation HTN3 SCARA3 24723138 1832363 Regulation HTR3A RIC3 20522555 1188045 Regulation HTR3A RIC3 20522555 1188055 Regulation HTR3A RIC3 20522555 1188062 Regulation HTR3A RIC3 20522555 1188071 Regulation HTR3A RIC3 20522555 1188073 Regulation HTR3B RIC3 20522555 1188046 Regulation HYAL2 TNF 11960552 276620 Regulation IARS FOXO1 24936657 2980601 Regulation IBD2 ARSA 18475455 1743806 Regulation IBD2 CD14 23730203 679434 Regulation IBD2 CHI3L1 19259344 3231607 Regulation IBD2 FAS 25045210 1760175 Regulation IBD2 IL1B 23915129 359269 Regulation IBD2 TNF 10562322 1513178 Regulation IBD2 TNF 12486099 1525569 Regulation IBD2 TNF 12625840 312775 Regulation IBD2 TNF 15694007 391946 Regulation IBD2 TNF 16259632 1624824 Regulation IBD2 TNF 18645606 1083722 Regulation IBD2 TNF 21853060 2542965 Regulation IBD2 TNF 22848704 2670164 Regulation IBD2 TNF 24339869 2891312 Regulation IBD3 ARSA 18475455 1743802 Regulation IBD3 CD14 23730203 679430 Regulation IBD3 CHI3L1 19259344 3231603 Regulation IBD3 FAS 25045210 1760167 Regulation IBD3 IL1B 23915129 359261 Regulation IBD3 TNF 10562322 1513174 Regulation IBD3 TNF 12486099 1525561 Regulation IBD3 TNF 12625840 312771 Regulation IBD3 TNF 15694007 391942 Regulation IBD3 TNF 16259632 1624820 Regulation IBD3 TNF 18645606 1083718 Regulation IBD3 TNF 21853060 2542961 Regulation IBD3 TNF 22848704 2670160 Regulation IBD3 TNF 24339869 2891308 Regulation IBD4 ARSA 18475455 1743807 Regulation IBD4 CD14 23730203 679435 Regulation IBD4 CHI3L1 19259344 3231608 Regulation IBD4 FAS 25045210 1760177 Regulation IBD4 IL1B 23915129 359271 Regulation IBD4 TNF 10562322 1513179 Regulation IBD4 TNF 12486099 1525570 Regulation IBD4 TNF 12625840 312776 Regulation IBD4 TNF 15694007 391947 Regulation IBD4 TNF 16259632 1624825 Regulation IBD4 TNF 18645606 1083723 Regulation IBD4 TNF 21853060 2542966 Regulation IBD4 TNF 22848704 2670165 Regulation IBD4 TNF 24339869 2891313 Regulation IBD5 ARSA 18475455 1743808 Regulation IBD5 CD14 23730203 679436 Regulation IBD5 CHI3L1 19259344 3231609 Regulation IBD5 FAS 25045210 1760179 Regulation IBD5 IL1B 23915129 359273 Regulation IBD5 TNF 10562322 1513180 Regulation IBD5 TNF 12486099 1525571 Regulation IBD5 TNF 12625840 312777 Regulation IBD5 TNF 15694007 391948 Regulation IBD5 TNF 16259632 1624826 Regulation IBD5 TNF 18645606 1083724 Regulation IBD5 TNF 21853060 2542967 Regulation IBD5 TNF 22848704 2670166 Regulation IBD5 TNF 24339869 2891314 Regulation IBD6 ARSA 18475455 1743809 Regulation IBD6 CD14 23730203 679437 Regulation IBD6 CHI3L1 19259344 3231610 Regulation IBD6 FAS 25045210 1760181 Regulation IBD6 IL1B 23915129 359275 Regulation IBD6 TNF 10562322 1513181 Regulation IBD6 TNF 12486099 1525572 Regulation IBD6 TNF 12625840 312778 Regulation IBD6 TNF 15694007 391949 Regulation IBD6 TNF 16259632 1624827 Regulation IBD6 TNF 18645606 1083725 Regulation IBD6 TNF 21853060 2542968 Regulation IBD6 TNF 22848704 2670167 Regulation IBD6 TNF 24339869 2891315 Regulation IBD7 ARSA 18475455 1743803 Regulation IBD7 CD14 23730203 679431 Regulation IBD7 CHI3L1 19259344 3231604 Regulation IBD7 FAS 25045210 1760169 Regulation IBD7 IL1B 23915129 359263 Regulation IBD7 TNF 10562322 1513175 Regulation IBD7 TNF 12486099 1525562 Regulation IBD7 TNF 12625840 312772 Regulation IBD7 TNF 15694007 391943 Regulation IBD7 TNF 16259632 1624821 Regulation IBD7 TNF 18645606 1083719 Regulation IBD7 TNF 21853060 2542962 Regulation IBD7 TNF 22848704 2670161 Regulation IBD7 TNF 24339869 2891309 Regulation IBD8 ARSA 18475455 1743804 Regulation IBD8 CD14 23730203 679432 Regulation IBD8 CHI3L1 19259344 3231605 Regulation IBD8 FAS 25045210 1760171 Regulation IBD8 IL1B 23915129 359265 Regulation IBD8 TNF 10562322 1513176 Regulation IBD8 TNF 12486099 1525567 Regulation IBD8 TNF 12625840 312773 Regulation IBD8 TNF 15694007 391944 Regulation IBD8 TNF 16259632 1624822 Regulation IBD8 TNF 18645606 1083720 Regulation IBD8 TNF 21853060 2542963 Regulation IBD8 TNF 22848704 2670162 Regulation IBD8 TNF 24339869 2891310 Regulation IBD9 ARSA 18475455 1743805 Regulation IBD9 CD14 23730203 679433 Regulation IBD9 CHI3L1 19259344 3231606 Regulation IBD9 FAS 25045210 1760173 Regulation IBD9 IL1B 23915129 359267 Regulation IBD9 TNF 10562322 1513177 Regulation IBD9 TNF 12486099 1525568 Regulation IBD9 TNF 12625840 312774 Regulation IBD9 TNF 15694007 391945 Regulation IBD9 TNF 16259632 1624823 Regulation IBD9 TNF 18645606 1083721 Regulation IBD9 TNF 21853060 2542964 Regulation IBD9 TNF 22848704 2670163 Regulation IBD9 TNF 24339869 2891311 Regulation ICAM1 ARSA 20877628 2475398 Regulation ICAM1 EPHB2 23098564 1231423 Regulation ICAM1 EPHB2 23457623 2759213 Regulation ICAM1 EPHB2 23626475 1715013 Regulation ICAM1 F2R 1385447 1298492 Regulation ICAM1 HES2 24891765 1759446 Regulation ICAM1 IL1B 12537603 3103818 Regulation ICAM1 ITGAL 7515097 1589176 Regulation ICAM1 ITGB2 1346139 1297622 Regulation ICAM1 ITGB2 15566616 658550 Regulation ICAM1 ITGB2 21970746 354731 Regulation ICAM1 MAP2K6 23626475 1715019 Regulation ICAM1 TLR7 18509450 2389708 Regulation ICAM1 TNF 10362102 414325 Regulation ICAM1 TNF 11133391 789757 Regulation ICAM1 TNF 11532196 368615 Regulation ICAM1 TNF 11667965 3102809 Regulation ICAM1 TNF 11817671 1738000 Regulation ICAM1 TNF 11817671 1738003 Regulation ICAM1 TNF 12537603 3103817 Regulation ICAM1 TNF 1385447 1298494 Regulation ICAM1 TNF 18096615 2032384 Regulation ICAM1 TNF 18289377 2112393 Regulation ICAM1 TNF 18931039 707115 Regulation ICAM1 TNF 21029292 590587 Regulation ICAM1 TNF 21152396 1912448 Regulation ICAM1 TNF 21375761 1697085 Regulation ICAM1 TNF 22028734 813418 Regulation ICAM1 TNF 22043276 2565967 Regulation ICAM1 TNF 22129197 1229979 Regulation ICAM1 TNF 22837985 940976 Regulation ICAM1 TNF 23264465 1810504 Regulation ICAM1 TNF 23317476 1155724 Regulation ICAM1 TNF 23317476 1155735 Regulation ICAM1 TNF 23671702 2792522 Regulation ICAM1 TNF 23789107 169905 Regulation ICAM1 TNF 23884101 220658 Regulation ICAM1 TNF 23987139 412473 Regulation ICAM1 TNF 23987139 412474 Regulation ICAM1 TNF 24228622 359355 Regulation ICAM1 TNF 24386129 2902852 Regulation ICAM1 TNF 24429403 1709602 Regulation ICAM1 TNF 24563688 2924008 Regulation ICAM1 TNF 24861337 653715 Regulation ICAM1 TNF 24884532 1701708 Regulation ICAM1 TNF 25032222 194870 Regulation ICAM1 TNF 7520473 1589474 Regulation ICAM1 TNF 7908214 444477 Regulation ICAM1 TNF 8666932 1597250 Regulation ICAM1 TNF 8666939 1597354 Regulation ICAM1 TNF 9400742 797442 Regulation ICAM1 TNF 9788898 798145 Regulation ICAM1 TNF PMC2062908 448367 Regulation ICAM2 ITGB2 24317296 1487273 Regulation ICAM2 TNF PMC2062908 448368 Regulation ICAM3 ITGAL 7901223 1443337 Regulation ICAM3 TNF PMC2062908 448369 Regulation ICAM4 TNF PMC2062908 448370 Regulation ICAM5 MMP28 23844251 2819652 Regulation ICAM5 MMP28 24853857 2973101 Regulation ICAM5 MMP7 23844251 2819667 Regulation ICAM5 MMP7 24853857 2973116 Regulation ICAM5 TNF PMC2062908 448371 Regulation ICOS EPHB2 24378539 1574362 Regulation ID1 AKT1 20796276 257149 Regulation ID1 AKT1 20796276 257150 Regulation ID1 AKT1 22139302 1879334 Regulation ID1 AKT1 22139302 1879335 Regulation ID1 AKT1 22139302 1879435 Regulation ID1 AKT2 20796276 257151 Regulation ID1 AKT2 20796276 257152 Regulation ID1 AKT2 22139302 1879336 Regulation ID1 AKT2 22139302 1879337 Regulation ID1 AKT2 22139302 1879436 Regulation ID1 AKT3 20796276 257153 Regulation ID1 AKT3 20796276 257154 Regulation ID1 AKT3 22139302 1879338 Regulation ID1 AKT3 22139302 1879339 Regulation ID1 AKT3 22139302 1879437 Regulation ID1 BMP1 23593444 2781383 Regulation ID1 BMP1 PMC3329082 3086473 Regulation ID1 BMP10 23593444 2781391 Regulation ID1 BMP10 PMC3329082 3086481 Regulation ID1 BMP15 23593444 2781384 Regulation ID1 BMP15 PMC3329082 3086474 Regulation ID1 BMP2 19366455 1676279 Regulation ID1 BMP2 21998639 2561816 Regulation ID1 BMP2 23593444 2781385 Regulation ID1 BMP2 24520257 844101 Regulation ID1 BMP2 PMC3329082 3086475 Regulation ID1 BMP3 23593444 2781386 Regulation ID1 BMP3 PMC3329082 3086476 Regulation ID1 BMP4 21949000 720830 Regulation ID1 BMP4 23028567 2691659 Regulation ID1 BMP4 23593444 2781387 Regulation ID1 BMP4 PMC3329082 3086477 Regulation ID1 BMP5 23593444 2781388 Regulation ID1 BMP5 PMC3329082 3086478 Regulation ID1 BMP6 23593444 2781389 Regulation ID1 BMP6 PMC3329082 3086479 Regulation ID1 BMP7 23593444 2781390 Regulation ID1 BMP7 PMC3329082 3086480 Regulation ID1 BTG2 24744701 869129 Regulation ID1 CCNA2 22139302 1879386 Regulation ID1 CDH1 23320068 2739504 Regulation ID1 EGF 25028095 1875785 Regulation ID1 EPC1 22139302 1879433 Regulation ID1 EPC2 22139302 1879434 Regulation ID1 FGF2 24142921 977602 Regulation ID1 FOXO3 20565867 1856222 Regulation ID1 GDF2 24670474 1125586 Regulation ID1 GJA1 24457967 571652 Regulation ID1 HAMP 24236640 450698 Regulation ID1 KLF17 19951400 1006918 Regulation ID1 MAP1LC3A 22815997 2667781 Regulation ID1 MCAM 22272201 1067123 Regulation ID1 MMP2 23714001 1699825 Regulation ID1 NOTCH1 19508709 1850897 Regulation ID1 NOTCH1 19508709 1850917 Regulation ID1 NOTCH1 24950189 2982060 Regulation ID1 NOTCH2 19508709 1850898 Regulation ID1 NOTCH2 19508709 1850918 Regulation ID1 NOTCH2 24950189 2982061 Regulation ID1 NOTCH3 19508709 1850899 Regulation ID1 NOTCH3 19508709 1850919 Regulation ID1 NOTCH3 24950189 2982062 Regulation ID1 NOTCH4 19508709 1850900 Regulation ID1 NOTCH4 19508709 1850920 Regulation ID1 NOTCH4 24950189 2982063 Regulation ID1 PDLIM7 20565867 1856221 Regulation ID1 PDLIM7 22110506 22125 Regulation ID1 PIK3CA 20796276 257155 Regulation ID1 PIK3CA 20796276 257156 Regulation ID1 PIK3CA 22139302 1879340 Regulation ID1 PIK3CA 22139302 1879341 Regulation ID1 PIK3CA 22139302 1879438 Regulation ID1 PIK3R1 20796276 257157 Regulation ID1 PIK3R1 20796276 257158 Regulation ID1 PIK3R1 22139302 1879342 Regulation ID1 PIK3R1 22139302 1879343 Regulation ID1 PIK3R1 22139302 1879439 Regulation ID1 SKIV2L 20862378 1672492 Regulation ID1 SMAD1 17509151 1999805 Regulation ID1 SMAD1 22348410 174968 Regulation ID1 SMAD2 17509151 1999806 Regulation ID1 SMAD2 22348410 174969 Regulation ID1 SMAD3 17509151 1999807 Regulation ID1 SMAD3 22348410 174970 Regulation ID1 SMAD4 17509151 1999808 Regulation ID1 SMAD4 20974850 1188966 Regulation ID1 SMAD4 22348410 174971 Regulation ID1 SMAD4 24554596 2213005 Regulation ID1 SMAD5 17509151 1999809 Regulation ID1 SMAD5 22348410 174972 Regulation ID1 SMAD5 25534700 3149045 Regulation ID1 SMAD6 17509151 1999810 Regulation ID1 SMAD6 22348410 174973 Regulation ID1 SMAD6 25534700 3149046 Regulation ID1 SMAD7 17509151 1999811 Regulation ID1 SMAD7 22348410 174974 Regulation ID1 SMAD7 25534700 3149047 Regulation ID1 SMAD9 17509151 1999812 Regulation ID1 SMAD9 22348410 174975 Regulation ID1 SRC 24457967 571678 Regulation ID1 SRC 25028095 1875746 Regulation ID1 SYCP2 22130070 553576 Regulation ID1 TNF 23531541 1103887 Regulation ID1 TNF 24620998 132068 Regulation ID1 TP53 16966095 792742 Regulation ID1 TTC37 20862378 1672493 Regulation ID1 VEGFA 24520257 844102 Regulation ID1 WDR61 20862378 1672494 Regulation ID1 ZNF148 25028095 1875737 Regulation ID1 ZNF148 25028095 1875776 Regulation ID3 EPHB2 11560990 1520826 Regulation ID3 ID1 23342268 491922 Regulation IDDM10 TNF 8064245 1593976 Regulation IDDM11 TNF 8064245 1593977 Regulation IDDM12 TNF 8064245 1593978 Regulation IDDM13 TNF 8064245 1593979 Regulation IDDM14 TNF 8064245 1593980 Regulation IDDM15 TNF 8064245 1593981 Regulation IDDM16 TNF 8064245 1593982 Regulation IDDM17 TNF 8064245 1593983 Regulation IDDM18 TNF 8064245 1593984 Regulation IDDM2 TNF 8064245 1593985 Regulation IDDM3 TNF 8064245 1593986 Regulation IDDM4 TNF 8064245 1593987 Regulation IDDM5 TNF 8064245 1593988 Regulation IDDM6 TNF 8064245 1593989 Regulation IDDM7 TNF 8064245 1593990 Regulation IDDM8 TNF 8064245 1593991 Regulation IDDM9 TNF 8064245 1593992 Regulation IDO1 TLR7 22708060 4572 Regulation IDO1 TNF 23882269 908249 Regulation IDO1 TNF 25123797 368560 Regulation IDO1 TNF 25379363 212538 Regulation IER3 TNF 19570030 137527 Regulation IFI27 ABL1 24098519 2857947 Regulation IFI27 ABL1 24098519 2857997 Regulation IFI27 AFAP1L2 22928011 2681352 Regulation IFI27 AKT1 14680481 457990 Regulation IFI27 AKT1 16780593 579941 Regulation IFI27 AKT1 21297943 2498593 Regulation IFI27 AKT1 22733130 2147524 Regulation IFI27 AKT1 22733130 2147655 Regulation IFI27 AKT1 24426773 1916669 Regulation IFI27 AKT1 24457952 571295 Regulation IFI27 AKT1 25247710 3009199 Regulation IFI27 AKT2 21297943 2498594 Regulation IFI27 AKT2 22733130 2147525 Regulation IFI27 AKT2 22733130 2147656 Regulation IFI27 AKT2 24426773 1916670 Regulation IFI27 AKT2 24457952 571296 Regulation IFI27 AKT2 25247710 3009200 Regulation IFI27 AKT3 21297943 2498595 Regulation IFI27 AKT3 22733130 2147526 Regulation IFI27 AKT3 22733130 2147657 Regulation IFI27 AKT3 24426773 1916671 Regulation IFI27 AKT3 24457952 571297 Regulation IFI27 AKT3 25247710 3009201 Regulation IFI27 APOBEC3G 23890083 378377 Regulation IFI27 APOBEC3G 23890083 378411 Regulation IFI27 APOBEC3G 23890083 378440 Regulation IFI27 ATOH1 23409082 2753494 Regulation IFI27 BCL10 20492666 1855402 Regulation IFI27 BCR 24098519 2857945 Regulation IFI27 BCR 24098519 2857995 Regulation IFI27 BLK 22797726 1951253 Regulation IFI27 BTRC 15833134 996362 Regulation IFI27 CA8 24870804 2975257 Regulation IFI27 CARD10 22615840 2643801 Regulation IFI27 CASP1 21153858 1148054 Regulation IFI27 CASP1 23386784 176218 Regulation IFI27 CASP10 21153858 1148055 Regulation IFI27 CASP10 23386784 176219 Regulation IFI27 CASP12 21153858 1148065 Regulation IFI27 CASP12 23386784 176229 Regulation IFI27 CASP14 21153858 1148056 Regulation IFI27 CASP14 23386784 176220 Regulation IFI27 CASP16 21153858 1148066 Regulation IFI27 CASP16 23386784 176230 Regulation IFI27 CASP2 21153858 1148057 Regulation IFI27 CASP2 23386784 176221 Regulation IFI27 CASP3 21153858 1148058 Regulation IFI27 CASP3 23386784 176222 Regulation IFI27 CASP4 21153858 1148059 Regulation IFI27 CASP4 23386784 176223 Regulation IFI27 CASP5 21153858 1148060 Regulation IFI27 CASP5 23386784 176224 Regulation IFI27 CASP6 21153858 1148061 Regulation IFI27 CASP6 23386784 176225 Regulation IFI27 CASP7 21153858 1148062 Regulation IFI27 CASP7 23386784 176226 Regulation IFI27 CASP8 21153858 1148063 Regulation IFI27 CASP8 23386784 176227 Regulation IFI27 CASP9 21153858 1148064 Regulation IFI27 CASP9 23386784 176228 Regulation IFI27 CCND1 21677822 641233 Regulation IFI27 CCND1 24086649 2855316 Regulation IFI27 CCND1 24143227 2867939 Regulation IFI27 CCND2 20831799 375773 Regulation IFI27 CDH1 23029392 2697080 Regulation IFI27 CDH1 9679152 1469030 Regulation IFI27 CDH1 9679152 1469043 Regulation IFI27 CDK16 25593992 2172361 Regulation IFI27 CDK16 25593992 2172362 Regulation IFI27 CDK2 16449999 427008 Regulation IFI27 CDK2 18922157 1503341 Regulation IFI27 CDK2 20975996 2478742 Regulation IFI27 CDK2 21423803 2508393 Regulation IFI27 CDK2 24086649 2855317 Regulation IFI27 CDK4 22754369 1096176 Regulation IFI27 CDK4 24086649 2855318 Regulation IFI27 CDKN1A 17088910 428330 Regulation IFI27 CDKN1A 17088910 428331 Regulation IFI27 CDKN1A 17088910 428357 Regulation IFI27 CDKN1A 17088910 428375 Regulation IFI27 CDKN1A 19267931 3109325 Regulation IFI27 CDKN1A 20200561 1719464 Regulation IFI27 CDKN1A 24358021 2285078 Regulation IFI27 CDKN2A PMC2360767 448450 Regulation IFI27 CFL1 23509459 1073485 Regulation IFI27 CUL1 15833134 996363 Regulation IFI27 CXCR2 22397681 1698171 Regulation IFI27 DAP 17088910 428340 Regulation IFI27 DND1 23890083 378378 Regulation IFI27 DND1 23890083 378441 Regulation IFI27 ECM1 9026502 1459209 Regulation IFI27 ECM2 9026502 1459210 Regulation IFI27 EGF 18534028 463021 Regulation IFI27 EGFR 23829771 410497 Regulation IFI27 EPHB2 23029392 2697061 Regulation IFI27 EPHB2 23029392 2697151 Regulation IFI27 EPHB2 24426773 1916668 Regulation IFI27 EVPL 24098519 2857946 Regulation IFI27 EVPL 24098519 2857996 Regulation IFI27 FARP2 24811221 2190588 Regulation IFI27 FOXO1 24741631 1621411 Regulation IFI27 FOXO3 19384426 668869 Regulation IFI27 FOXO3 20661471 2456701 Regulation IFI27 FOXO3 23259070 1719140 Regulation IFI27 FOXO3 23434653 1101835 Regulation IFI27 GFER 21346186 1788547 Regulation IFI27 GPR3 19526062 2419428 Regulation IFI27 HEPACAM 20226097 411793 Regulation IFI27 HES1 23409082 2753492 Regulation IFI27 HGF 24426773 1916682 Regulation IFI27 HLA-G 21887223 2547988 Regulation IFI27 HSPB1 24143227 2867940 Regulation IFI27 IAPP 17088910 428341 Regulation IFI27 ID3 18069898 2304629 Regulation IFI27 ID3 18069898 2304632 Regulation IFI27 ID3 18069898 2304639 Regulation IFI27 ID3 18069898 2304653 Regulation IFI27 ID3 18069898 2304656 Regulation IFI27 ID3 18069898 2304658 Regulation IFI27 IFI27L1 22397681 1698170 Regulation IFI27 IL6 15583018 1533988 Regulation IFI27 IRF4 21818355 2540657 Regulation IFI27 KAT2B 22547391 2074932 Regulation IFI27 LGALS3 24971481 548980 Regulation IFI27 LGALS3 24971481 549033 Regulation IFI27 MALT1 20492666 1855401 Regulation IFI27 MAP2K1 14680481 457991 Regulation IFI27 MAP2K2 14680481 457992 Regulation IFI27 MAP2K3 14680481 457993 Regulation IFI27 MAP2K4 14680481 457994 Regulation IFI27 MAP2K5 14680481 457995 Regulation IFI27 MAP2K6 14680481 457996 Regulation IFI27 MAP2K7 14680481 457997 Regulation IFI27 MAPK1 14680481 457998 Regulation IFI27 MAPK1 23029392 2697082 Regulation IFI27 MAPK1 23762493 2804160 Regulation IFI27 MAPK10 14680481 457999 Regulation IFI27 MAPK10 23029392 2697083 Regulation IFI27 MAPK10 23762493 2804161 Regulation IFI27 MAPK11 14680481 458000 Regulation IFI27 MAPK11 23029392 2697084 Regulation IFI27 MAPK11 23762493 2804162 Regulation IFI27 MAPK12 14680481 458001 Regulation IFI27 MAPK12 23029392 2697085 Regulation IFI27 MAPK12 23762493 2804163 Regulation IFI27 MAPK13 14680481 458002 Regulation IFI27 MAPK13 23029392 2697086 Regulation IFI27 MAPK13 23762493 2804164 Regulation IFI27 MAPK14 14680481 458003 Regulation IFI27 MAPK14 23029392 2697087 Regulation IFI27 MAPK14 23762493 2804165 Regulation IFI27 MAPK15 14680481 457989 Regulation IFI27 MAPK15 23029392 2697081 Regulation IFI27 MAPK15 23762493 2804159 Regulation IFI27 MAPK3 14680481 458004 Regulation IFI27 MAPK3 23029392 2697088 Regulation IFI27 MAPK3 23762493 2804166 Regulation IFI27 MAPK3 23762493 2804201 Regulation IFI27 MAPK4 14680481 458005 Regulation IFI27 MAPK4 23029392 2697089 Regulation IFI27 MAPK4 23762493 2804167 Regulation IFI27 MAPK6 14680481 458006 Regulation IFI27 MAPK6 23029392 2697090 Regulation IFI27 MAPK6 23762493 2804168 Regulation IFI27 MAPK7 14680481 458007 Regulation IFI27 MAPK7 23029392 2697091 Regulation IFI27 MAPK7 23762493 2804169 Regulation IFI27 MAPK8 14680481 458008 Regulation IFI27 MAPK8 23029392 2697092 Regulation IFI27 MAPK8 23762493 2804170 Regulation IFI27 MAPK9 14680481 458009 Regulation IFI27 MAPK9 23029392 2697093 Regulation IFI27 MAPK9 23762493 2804171 Regulation IFI27 MAPKAP1 22733130 2147518 Regulation IFI27 MAT2A 19025580 1503413 Regulation IFI27 MIR150 25435958 2170282 Regulation IFI27 MLST8 22733130 2147519 Regulation IFI27 MLST8 22733130 2147520 Regulation IFI27 MLST8 22733130 2147578 Regulation IFI27 MTOR 22733130 2147527 Regulation IFI27 MTOR 22733130 2147528 Regulation IFI27 MTOR 22733130 2147580 Regulation IFI27 MTOR 23389114 809978 Regulation IFI27 MYLIP 19153141 2040785 Regulation IFI27 MYLIP 20618998 256617 Regulation IFI27 MYLIP 21909123 13303 Regulation IFI27 MYLIP 22086949 2069449 Regulation IFI27 MYLIP 22754369 1096177 Regulation IFI27 MYLIP 23056458 2701591 Regulation IFI27 MYLIP 23409140 2753765 Regulation IFI27 MYLIP 23409140 2753766 Regulation IFI27 MYLIP 23409140 2753777 Regulation IFI27 MYLIP 23409140 2753795 Regulation IFI27 MYLIP 23472073 2763858 Regulation IFI27 MYLIP 23613955 2782839 Regulation IFI27 MYLIP 24137356 2165638 Regulation IFI27 MYLIP 24314651 3216472 Regulation IFI27 MYLIP 24727952 2951762 Regulation IFI27 MYLIP 24727952 2951769 Regulation IFI27 MYLIP 24970806 2193925 Regulation IFI27 MYLIP 25141103 1129096 Regulation IFI27 MYLIP 25435958 2170281 Regulation IFI27 MYLIP 25435958 2170285 Regulation IFI27 NA 9679152 1469039 Regulation IFI27 NCOA3 23511556 440355 Regulation IFI27 NFATC1 21148296 1784385 Regulation IFI27 NFATC1 21148296 1784443 Regulation IFI27 NFATC4 21148296 1784386 Regulation IFI27 NFATC4 21148296 1784444 Regulation IFI27 NME1 19123928 1994578 Regulation IFI27 NME1 19123928 1994656 Regulation IFI27 NR4A1 25269081 3011881 Regulation IFI27 PARP1 18412984 323112 Regulation IFI27 PARP1 24367566 2900234 Regulation IFI27 PCNA 18922157 1503342 Regulation IFI27 PCNA 24083250 184403 Regulation IFI27 PFKFB3 25032860 577604 Regulation IFI27 PFKFB3 25032860 577611 Regulation IFI27 PI3 20200561 1719460 Regulation IFI27 PI3 24426773 1916672 Regulation IFI27 PIEZO1 12188931 277035 Regulation IFI27 PIEZO1 12188931 277044 Regulation IFI27 PIK3CA 14680481 458010 Regulation IFI27 PIK3CA 16780593 579942 Regulation IFI27 PIK3CA 22733130 2147529 Regulation IFI27 PIK3CA 22733130 2147530 Regulation IFI27 PIK3CA 22733130 2147643 Regulation IFI27 PIK3CA 22733130 2147658 Regulation IFI27 PIK3CA 24578720 3177514 Regulation IFI27 PIK3CA 9679152 1469044 Regulation IFI27 PIK3R1 14680481 458011 Regulation IFI27 PIK3R1 16780593 579943 Regulation IFI27 PIK3R1 22733130 2147531 Regulation IFI27 PIK3R1 22733130 2147532 Regulation IFI27 PIK3R1 22733130 2147644 Regulation IFI27 PIK3R1 22733130 2147659 Regulation IFI27 PIK3R1 24578720 3177515 Regulation IFI27 PIK3R1 9679152 1469045 Regulation IFI27 PLD1 23576547 1813451 Regulation IFI27 PLD1 23576547 1813461 Regulation IFI27 PLD2 23576547 1813452 Regulation IFI27 POLDIP2 22404972 528391 Regulation IFI27 PRKAA1 20170512 481473 Regulation IFI27 PRKAA2 20170512 481474 Regulation IFI27 PRKAB1 20170512 481475 Regulation IFI27 PRKAB2 20170512 481476 Regulation IFI27 PRKAG1 20170512 481477 Regulation IFI27 PRKAG2 20170512 481478 Regulation IFI27 PRMT6 22916108 2680004 Regulation IFI27 PRR5 22733130 2147523 Regulation IFI27 PTEN 21986318 3079222 Regulation IFI27 PTEN 23472073 2763859 Regulation IFI27 PTGS2 22397681 1698172 Regulation IFI27 PTHLH 20876711 716617 Regulation IFI27 RAC1 19538723 1227214 Regulation IFI27 RALA 23576547 1813447 Regulation IFI27 RALA 23576547 1813462 Regulation IFI27 REST 22665064 2147166 Regulation IFI27 REST 22665064 2147215 Regulation IFI27 RET 23509459 1073486 Regulation IFI27 RHOA 10427091 1248776 Regulation IFI27 RICTOR 22733130 2147521 Regulation IFI27 RICTOR 22733130 2147522 Regulation IFI27 RICTOR 22733130 2147579 Regulation IFI27 RNF112 21566658 547297 Regulation IFI27 RNF112 24359566 1232752 Regulation IFI27 RPL11 23056458 2701590 Regulation IFI27 SETD2 21103079 2114980 Regulation IFI27 SF3B1 24811221 2190587 Regulation IFI27 SF3B3 23951410 170573 Regulation IFI27 SF3B3 23951410 170574 Regulation IFI27 SFN 23476648 1674519 Regulation IFI27 SKP1 15833134 996360 Regulation IFI27 SKP2 12188931 277034 Regulation IFI27 SKP2 15833134 996361 Regulation IFI27 SKP2 17724117 1343504 Regulation IFI27 SKP2 20525401 313241 Regulation IFI27 SKP2 21182801 3111840 Regulation IFI27 SKP2 21255415 586040 Regulation IFI27 SKP2 21255415 586048 Regulation IFI27 SKP2 22547391 2074913 Regulation IFI27 SKP2 22558406 2625562 Regulation IFI27 SKP2 23029392 2697148 Regulation IFI27 SKP2 23077551 2704777 Regulation IFI27 SKP2 23409140 2753764 Regulation IFI27 SKP2 23409140 2753776 Regulation IFI27 SKP2 23409140 2753794 Regulation IFI27 SKP2 24083250 184402 Regulation IFI27 SKP2 24463355 2008203 Regulation IFI27 SMAD3 23434653 1101836 Regulation IFI27 SP3 19212434 2405577 Regulation IFI27 STAT1 23352233 1040786 Regulation IFI27 STAT3 25412315 579352 Regulation IFI27 STAT6 24401087 271098 Regulation IFI27 TAB2 20492666 1855400 Regulation IFI27 TAP1 22723949 2655379 Regulation IFI27 TCF12 24741631 1621399 Regulation IFI27 TCF15 24741631 1621400 Regulation IFI27 TCF19 24741631 1621401 Regulation IFI27 TCF20 24741631 1621402 Regulation IFI27 TCF21 24741631 1621403 Regulation IFI27 TCF23 24741631 1621407 Regulation IFI27 TCF24 24741631 1621409 Regulation IFI27 TCF25 24741631 1621408 Regulation IFI27 TCF3 24741631 1621404 Regulation IFI27 TCF4 24741631 1621405 Regulation IFI27 TCF7 24741631 1621406 Regulation IFI27 TMED7 23029392 2697116 Regulation IFI27 TP53 19267931 3109315 Regulation IFI27 TP53 24788701 2959238 Regulation IFI27 TRAF6 20492666 1855398 Regulation IFI27 TRIM21 22522706 771782 Regulation IFI27 TYK2 22723949 2655378 Regulation IFI27 UBE2V1 20492666 1855399 Regulation IFI27 UCA1 24457952 571294 Regulation IFI27 USP37 22665064 2147183 Regulation IFI27 VHL 19602254 253750 Regulation IFI27L1 IFI27 22397681 1698154 Regulation IFI44 FAS 16818723 1330946 Regulation IFI44 MIP 17233909 351842 Regulation IFIH1 TLR7 21079690 3049436 Regulation IFIT2 EPHB2 21368873 550844 Regulation IFIT5 TNF 7519620 1436181 Regulation IFN1@ OASL 23874199 3063145 Regulation IFN1@ TLR7 19047436 1552945 Regulation IFN1@ TLR7 19047436 1552946 Regulation IFN1@ TLR7 19047436 1552994 Regulation IFN1@ TLR7 20975040 1561053 Regulation IFN1@ TLR7 21994626 3219428 Regulation IFN1@ TLR7 21994626 3219429 Regulation IFN1@ TLR7 21994626 3219528 Regulation IFN1@ TLR7 21998693 2561936 Regulation IFN1@ TLR7 22279442 923962 Regulation IFN1@ TLR7 23717310 907022 Regulation IFN1@ TLR7 24497833 3066113 Regulation IFN1@ TLR7 25203514 3006382 Regulation IFNA1 ADRB2 23724117 2799032 Regulation IFNAR2 TLR7 19624844 116086 Regulation IFNB1 EPHB2 22427889 2610558 Regulation IFNB1 TLR7 24270516 1959406 Regulation IFNG TLR7 24734221 865098 Regulation IFNG TNF 23755050 907407 Regulation IFNG TNF 2390468 441484 Regulation IFNL1 TLR7 24286242 130946 Regulation IFNR TNF 10389988 414543 Regulation IGF1 ARSG 22194889 2583263 Regulation IGF1 ARSG 22194889 2583264 Regulation IGF1 ARSG 22194889 2583265 Regulation IGF1 CDKN1C 17517131 300014 Regulation IGF1 EFNB1 21795402 1793160 Regulation IGF1 EFNB1 21795402 1793224 Regulation IGF1 FOXO1 19337549 3208681 Regulation IGF1 FOXO1 23844554 473471 Regulation IGF1 FOXO1 23844554 473532 Regulation IGF1 IGFBP1 18769480 2395896 Regulation IGF1 IGFBP1 21931746 2554308 Regulation IGF1 IGFBP1 22363400 2598851 Regulation IGF1 IGFBP1 23383064 2747736 Regulation IGF1 IGFBP1 24204984 2875076 Regulation IGF1 IGFBP1 24899777 175101 Regulation IGF1 IGFBP1 24904527 880733 Regulation IGF1 IGFBP1 25226394 3007745 Regulation IGF1 IL1B 15813980 1624696 Regulation IGF1 LBP 23894366 2824404 Regulation IGF1 MAP2K6 21699731 1862640 Regulation IGF1 TFPI2 20485667 2450640 Regulation IGF1 TNF 15813980 1624695 Regulation IGF1 TNF 22894827 126639 Regulation IGF1 TNF 25013674 1143396 Regulation IGF1R EPHB2 23382729 878048 Regulation IGF1R MAP2K6 23382729 878057 Regulation IGF1R TM4SF19 25344917 2206264 Regulation IGF2 FOXO1 23206814 3161255 Regulation IGF2 FOXO1 23844554 473475 Regulation IGF2 FOXO1 23844554 473536 Regulation IGF2 IGFBP1 18769480 2395897 Regulation IGF2 IGFBP1 21931746 2554310 Regulation IGF2 IGFBP1 22363400 2598858 Regulation IGF2 IGFBP1 23383064 2747743 Regulation IGF2 TNF 25013674 1143397 Regulation IGF2R RAB31 24788816 2959651 Regulation IGF2R RAB31 24788816 2959678 Regulation IGF2R RAB31 25472813 1486020 Regulation IGFALS PGC 18464922 3072313 Regulation IGFALS PGC 25057490 195423 Regulation IGFALS TNF 20195368 2441795 Regulation IGFBP1 COMT 23236253 983751 Regulation IGFBP1 ECM1 12473169 457481 Regulation IGFBP1 ECM2 12473169 457482 Regulation IGFBP1 EGF 8595162 445315 Regulation IGFBP1 FOXO1 14668045 830420 Regulation IGFBP1 FOXO1 15200677 3095789 Regulation IGFBP1 FOXO1 18648506 2393419 Regulation IGFBP1 FOXO1 22510882 771776 Regulation IGFBP1 FOXO1 23349855 2743547 Regulation IGFBP1 FOXO3 18648506 2393420 Regulation IGFBP1 FOXO4 18648506 2393421 Regulation IGFBP1 FOXO6 18648506 2393418 Regulation IGFBP1 HMGA1 22355763 3130422 Regulation IGFBP1 HOXA10 21814398 1636510 Regulation IGFBP1 IGF1 11972897 297937 Regulation IGFBP1 IGF1 12153762 791181 Regulation IGFBP1 IGF1 22363400 2598865 Regulation IGFBP1 IGF1 22848683 2670073 Regulation IGFBP1 IGF1 25218581 3176691 Regulation IGFBP1 IGF2 11972897 297938 Regulation IGFBP1 IGF2 22363400 2598866 Regulation IGFBP1 INS 14668045 830410 Regulation IGFBP1 INS 14668045 830419 Regulation IGFBP1 INS 14668047 830504 Regulation IGFBP1 INS 15350195 369610 Regulation IGFBP1 INS 15350195 369618 Regulation IGFBP1 INS 16600022 369961 Regulation IGFBP1 INS 17662149 108830 Regulation IGFBP1 INS 17692117 389816 Regulation IGFBP1 INS 18234122 3096590 Regulation IGFBP1 INS 18234122 3096591 Regulation IGFBP1 INS 18234122 3096592 Regulation IGFBP1 INS 18234122 3096593 Regulation IGFBP1 INS 18234122 3096594 Regulation IGFBP1 INS 18234122 3096595 Regulation IGFBP1 INS 18234122 3096596 Regulation IGFBP1 INS 18234122 3096597 Regulation IGFBP1 INS 18234122 3096609 Regulation IGFBP1 INS 18234122 3096610 Regulation IGFBP1 INS 18234122 3096611 Regulation IGFBP1 INS 18234122 3096612 Regulation IGFBP1 INS 18234122 3096613 Regulation IGFBP1 INS 18234122 3096614 Regulation IGFBP1 INS 18234122 3096622 Regulation IGFBP1 INS 18234122 3096623 Regulation IGFBP1 INS 18234122 3096628 Regulation IGFBP1 INS 18596909 2391656 Regulation IGFBP1 INS 20216949 1489832 Regulation IGFBP1 INS 20216949 1489833 Regulation IGFBP1 INS 20216949 1489834 Regulation IGFBP1 INS 20216949 1489853 Regulation IGFBP1 INS 20216949 1489865 Regulation IGFBP1 INS 20216949 1489871 Regulation IGFBP1 INS 20216949 1489872 Regulation IGFBP1 INS 20216949 1489878 Regulation IGFBP1 INS 20216949 1489879 Regulation IGFBP1 INS 22355763 3130418 Regulation IGFBP1 INS 22493645 1491762 Regulation IGFBP1 INS 22950808 266230 Regulation IGFBP1 INS 24204984 2875085 Regulation IGFBP1 INS 24555152 1153216 Regulation IGFBP1 INS 24904693 640844 Regulation IGFBP1 INS 7577447 443969 Regulation IGFBP1 INS 8180007 444610 Regulation IGFBP1 INS 9662244 447293 Regulation IGFBP1 LEP 24790314 650044 Regulation IGFBP1 MTOR 20216949 1489831 Regulation IGFBP1 MTOR 20216949 1489877 Regulation IGFBP1 NOTCH2 25397403 3027151 Regulation IGFBP1 SETD2 24574272 135765 Regulation IGFBP1 SIL1 17042939 319213 Regulation IGFBP1 TP53 22674894 778748 Regulation IGFBP3 FOXA1 22879989 2673400 Regulation IGFBP3 FOXA1 22879989 2673401 Regulation IGFBP3 FOXA1 22879989 2673429 Regulation IGFBP3 FOXA1 22879989 2673433 Regulation IGFBP3 FOXA1 22879989 2673434 Regulation IGFBP3 TNF 23592916 1915856 Regulation IGFBP3 TNF 24964199 2983534 Regulation IGFBP3 TNF 25073020 2993128 Regulation IGFBP5 EPHB2 23626478 1715092 Regulation IGKV1-27 TNF 17620405 1341846 Regulation IGKV1-27 TNF 24741605 1621317 Regulation IHH EPHB2 25003010 3092922 Regulation IKBKB IFI27 25099287 3144970 Regulation IKBKB TLR7 22984582 2689206 Regulation IKBKB TLR7 24527057 825307 Regulation IKBKB TNF 10359587 1511926 Regulation IKBKB TNF 10359587 1511950 Regulation IKBKB TNF 11238593 1519033 Regulation IKBKB TNF 17925009 233622 Regulation IKBKB TNF 20087353 434415 Regulation IKBKB TNF 20351780 2444606 Regulation IKBKB TNF 21119000 1783953 Regulation IKBKB TNF 21119000 1783977 Regulation IKBKB TNF 22768286 2660434 Regulation IKBKB TNF 23104095 1958302 Regulation IKBKB TNF 24386331 2903506 Regulation IKBKB TNF 24386331 2903544 Regulation IKBKB TNF 24487321 1959864 Regulation IKBKG IFI27 25099287 3144971 Regulation IKBKG TLR7 22984582 2689216 Regulation IKBKG TLR7 24527057 825317 Regulation IKBKG TNF 10359587 1511928 Regulation IKBKG TNF 10359587 1511952 Regulation IKBKG TNF 11238593 1519034 Regulation IKBKG TNF 17925009 233623 Regulation IKBKG TNF 20087353 434416 Regulation IKBKG TNF 20351780 2444607 Regulation IKBKG TNF 20484576 1776878 Regulation IKBKG TNF 20484576 1776893 Regulation IKBKG TNF 21119000 1783955 Regulation IKBKG TNF 21119000 1783978 Regulation IKBKG TNF 22768286 2660435 Regulation IKBKG TNF 23104095 1958279 Regulation IKBKG TNF 23104095 1958304 Regulation IKBKG TNF 24386331 2903507 Regulation IKBKG TNF 24386331 2903545 Regulation IKBKG TNF 24487321 1959865 Regulation IL10 ALOX5 12417634 1525204 Regulation IL10 CD14 17242961 810107 Regulation IL10 CD14 17916230 3108372 Regulation IL10 CD14 20946675 1723289 Regulation IL10 CD14 20946675 1723290 Regulation IL10 CD14 20946675 1723291 Regulation IL10 CST6 22072824 1713249 Regulation IL10 CST6 25275395 2373014 Regulation IL10 EPHB2 18648505 2393085 Regulation IL10 EPHB2 19667062 1555688 Regulation IL10 EPHB2 21253577 3050660 Regulation IL10 EPHB2 21253577 3050661 Regulation IL10 EPHB2 21253577 3050662 Regulation IL10 EPHB2 21253577 3050663 Regulation IL10 EPHB2 23800014 1232286 Regulation IL10 EPHB2 24191131 1754980 Regulation IL10 EPHB2 24330710 538612 Regulation IL10 EPHB2 24855454 1627900 Regulation IL10 EPHB2 24855454 1627915 Regulation IL10 FOXO1 19651810 710752 Regulation IL10 IL1B 15154610 630055 Regulation IL10 IL1B 22020329 2144335 Regulation IL10 IL1R2 2143773 1563019 Regulation IL10 IL1R2 2664067 1577711 Regulation IL10 JAG1 7905018 1592874 Regulation IL10 MAP2K6 24855454 1627910 Regulation IL10 NGFR 22880054 2674053 Regulation IL10 PTGER2 25098409 2995467 Regulation IL10 RNF150 23847409 649762 Regulation IL10 S100A7 22230654 3112897 Regulation IL10 STAT4 22969768 904245 Regulation IL10 TLR7 17485512 1545822 Regulation IL10 TLR7 17485512 1545941 Regulation IL10 TLR7 17893200 1547152 Regulation IL10 TLR7 17918201 807215 Regulation IL10 TLR7 19667062 1555648 Regulation IL10 TLR7 20821041 1491432 Regulation IL10 TLR7 20837696 1560153 Regulation IL10 TLR7 21152080 2486098 Regulation IL10 TLR7 22197976 1956480 Regulation IL10 TLR7 22526791 94539 Regulation IL10 TLR7 22649499 2646608 Regulation IL10 TLR7 22649499 2646640 Regulation IL10 TLR7 22808181 2665025 Regulation IL10 TLR7 22815909 2666689 Regulation IL10 TLR7 22880012 2673578 Regulation IL10 TLR7 22911108 3058869 Regulation IL10 TLR7 23028609 2691909 Regulation IL10 TLR7 23194300 356094 Regulation IL10 TLR7 23268427 3225197 Regulation IL10 TLR7 23566714 128140 Regulation IL10 TLR7 23826189 2810743 Regulation IL10 TLR7 24743542 2955610 Regulation IL10 TLR7 25112836 1619103 Regulation IL10 TLR7 25566514 865358 Regulation IL10 TNF 10408703 414820 Regulation IL10 TNF 10408703 414821 Regulation IL10 TNF 10408703 414856 Regulation IL10 TNF 11577995 1737877 Regulation IL10 TNF 11577995 1737881 Regulation IL10 TNF 11879539 98608 Regulation IL10 TNF 12110137 99165 Regulation IL10 TNF 15154610 630037 Regulation IL10 TNF 19451266 1554830 Regulation IL10 TNF 19907653 2430902 Regulation IL10 TNF 20808962 2473163 Regulation IL10 TNF 22028806 2564406 Regulation IL10 TNF 22125677 2115087 Regulation IL10 TNF 22880012 2673577 Regulation IL10 TNF 23691105 2794520 Regulation IL10 TNF 24130911 2372253 Regulation IL10 TNF 24371377 1756059 Regulation IL10 TNF 24911280 2977603 Regulation IL10 TNF 25205937 90021 Regulation IL10 TNF 7964475 1593465 Regulation IL10 TNF 7964475 1593466 Regulation IL10 TNF 7964475 1593467 Regulation IL10 TNF 7964475 1593473 Regulation IL10 TNF 8163935 1594286 Regulation IL11 IL1B 22020329 2144336 Regulation IL11 IL1R2 2143773 1563021 Regulation IL11 IL1R2 2664067 1577713 Regulation IL11 TNF 11132773 1737257 Regulation IL11 TNF 20808962 2473164 Regulation IL12A ALOX5 12417634 1525199 Regulation IL12A ALOX5 23613965 2782923 Regulation IL12A CD14 15841259 810596 Regulation IL12A EPHB2 18648505 2393201 Regulation IL12A EPHB2 18648505 2393312 Regulation IL12A EPHB2 19667062 1555653 Regulation IL12A EPHB2 19667062 1555689 Regulation IL12A EPHB2 19667062 1555755 Regulation IL12A EPHB2 20396387 1214737 Regulation IL12A EPHB2 22537317 355889 Regulation IL12A EPHB2 22852877 532947 Regulation IL12A STAT4 10704465 1514556 Regulation IL12A STAT4 20843320 1858912 Regulation IL12A STAT4 21687641 139640 Regulation IL12A STAT4 22110388 1058562 Regulation IL12A STAT4 24876666 1758851 Regulation IL12A TLR7 15851485 1535865 Regulation IL12A TLR7 15851485 1535866 Regulation IL12A TLR7 15851485 1535867 Regulation IL12A TLR7 16365150 1539090 Regulation IL12A TLR7 17371930 1544878 Regulation IL12A TLR7 17485511 1545676 Regulation IL12A TLR7 17485512 1545832 Regulation IL12A TLR7 17485512 1545884 Regulation IL12A TLR7 18411340 1550383 Regulation IL12A TLR7 18461564 807289 Regulation IL12A TLR7 18461564 807387 Regulation IL12A TLR7 18461564 807458 Regulation IL12A TLR7 18461564 807498 Regulation IL12A TLR7 18490488 1551248 Regulation IL12A TLR7 18584038 3072635 Regulation IL12A TLR7 18584038 3072725 Regulation IL12A TLR7 18584038 3073512 Regulation IL12A TLR7 18584038 3073513 Regulation IL12A TLR7 18584038 3074247 Regulation IL12A TLR7 19430534 2416269 Regulation IL12A TLR7 19609356 3044627 Regulation IL12A TLR7 19766674 1042575 Regulation IL12A TLR7 19770272 1556381 Regulation IL12A TLR7 20193084 1727947 Regulation IL12A TLR7 21060840 2480862 Regulation IL12A TLR7 21060840 2480951 Regulation IL12A TLR7 21124820 3050095 Regulation IL12A TLR7 21152080 2486113 Regulation IL12A TLR7 21637332 2525803 Regulation IL12A TLR7 21931552 3053391 Regulation IL12A TLR7 21994612 3218966 Regulation IL12A TLR7 22863292 366871 Regulation IL12A TLR7 23071254 1569711 Regulation IL12A TLR7 23162549 904971 Regulation IL12A TLR7 23755218 2802058 Regulation IL12A TLR7 23940256 1573377 Regulation IL12A TLR7 23967307 2835820 Regulation IL12A TLR7 24098413 2856228 Regulation IL12A TLR7 24098413 2856252 Regulation IL12A TLR7 24155889 2871068 Regulation IL12A TLR7 24165808 808934 Regulation IL12A TLR7 24178712 3223567 Regulation IL12A TLR7 24282405 909992 Regulation IL12A TLR7 24708419 1043519 Regulation IL12A TLR7 24910635 913038 Regulation IL12A TLR7 25429207 3216578 Regulation IL12A TNF 12223112 99379 Regulation IL12A TNF 12223112 99403 Regulation IL12A TNF 14568984 1529257 Regulation IL12A TNF 15657292 1534266 Regulation IL12A TNF 19492047 2418012 Regulation IL12A TNF 21199955 1562321 Regulation IL12A TNF 23853585 3062964 Regulation IL12A TNF 7722441 1591783 Regulation IL12A TNF 9104810 1600624 Regulation IL12A TNFSF10 11257133 1519061 Regulation IL12A TP63 10952720 1516575 Regulation IL12A TP63 9348310 1601843 Regulation IL12B ALOX5 12417634 1525200 Regulation IL12B ALOX5 23613965 2782924 Regulation IL12B CD14 15841259 810598 Regulation IL12B EPHB2 18648505 2393216 Regulation IL12B EPHB2 18648505 2393327 Regulation IL12B EPHB2 19667062 1555657 Regulation IL12B EPHB2 19667062 1555692 Regulation IL12B EPHB2 19667062 1555758 Regulation IL12B EPHB2 20396387 1214738 Regulation IL12B EPHB2 22537317 355890 Regulation IL12B EPHB2 22852877 532948 Regulation IL12B RORC 23469228 2763573 Regulation IL12B STAT4 10704465 1514557 Regulation IL12B STAT4 20843320 1858915 Regulation IL12B STAT4 21687641 139641 Regulation IL12B STAT4 22110388 1058563 Regulation IL12B STAT4 24876666 1758852 Regulation IL12B TLR7 15851485 1535897 Regulation IL12B TLR7 15851485 1535898 Regulation IL12B TLR7 15851485 1535899 Regulation IL12B TLR7 16365150 1539100 Regulation IL12B TLR7 17371930 1544888 Regulation IL12B TLR7 17485511 1545686 Regulation IL12B TLR7 17485512 1545843 Regulation IL12B TLR7 17485512 1545894 Regulation IL12B TLR7 18411340 1550393 Regulation IL12B TLR7 18461564 807300 Regulation IL12B TLR7 18461564 807397 Regulation IL12B TLR7 18461564 807468 Regulation IL12B TLR7 18461564 807508 Regulation IL12B TLR7 18490488 1551268 Regulation IL12B TLR7 18584038 3072645 Regulation IL12B TLR7 18584038 3072735 Regulation IL12B TLR7 18584038 3073532 Regulation IL12B TLR7 18584038 3073533 Regulation IL12B TLR7 18584038 3074257 Regulation IL12B TLR7 19430534 2416271 Regulation IL12B TLR7 19609356 3044637 Regulation IL12B TLR7 19766674 1042585 Regulation IL12B TLR7 19770272 1556391 Regulation IL12B TLR7 20193084 1727957 Regulation IL12B TLR7 21060840 2480873 Regulation IL12B TLR7 21060840 2480961 Regulation IL12B TLR7 21124820 3050096 Regulation IL12B TLR7 21152080 2486115 Regulation IL12B TLR7 21188221 1081720 Regulation IL12B TLR7 21637332 2525813 Regulation IL12B TLR7 21931552 3053401 Regulation IL12B TLR7 21994612 3218977 Regulation IL12B TLR7 22164330 97570 Regulation IL12B TLR7 22417709 125136 Regulation IL12B TLR7 22863292 366881 Regulation IL12B TLR7 23071254 1569721 Regulation IL12B TLR7 23162549 904981 Regulation IL12B TLR7 23755218 2802068 Regulation IL12B TLR7 23940256 1573387 Regulation IL12B TLR7 23967307 2835832 Regulation IL12B TLR7 24098413 2856238 Regulation IL12B TLR7 24098413 2856262 Regulation IL12B TLR7 24155889 2871078 Regulation IL12B TLR7 24165808 808944 Regulation IL12B TLR7 24178712 3223568 Regulation IL12B TLR7 24282405 910002 Regulation IL12B TLR7 24708419 1043529 Regulation IL12B TLR7 24910635 913039 Regulation IL12B TLR7 25429207 3216588 Regulation IL12B TNF 12223112 99381 Regulation IL12B TNF 12223112 99404 Regulation IL12B TNF 14568984 1529260 Regulation IL12B TNF 15657292 1534267 Regulation IL12B TNF 19492047 2418013 Regulation IL12B TNF 21199955 1562322 Regulation IL12B TNF 22545055 1144852 Regulation IL12B TNF 22545055 1144856 Regulation IL12B TNF 23853585 3062965 Regulation IL12B TNF 7722441 1591784 Regulation IL12B TNF 9104810 1600625 Regulation IL12B TNFSF10 11257133 1519062 Regulation IL12B TP63 10952720 1516576 Regulation IL12B TP63 9348310 1601847 Regulation IL12RB1 RCAN1 18755030 324113 Regulation IL12RB1 STAT4 10952721 1516674 Regulation IL12RB2 STAT4 10952721 1516675 Regulation IL13 EPHB2 15833106 3104959 Regulation IL13 EPHB2 21989417 1041864 Regulation IL13 IL1B 22020329 2144337 Regulation IL13 IL1R2 2143773 1563023 Regulation IL13 IL1R2 2664067 1577715 Regulation IL13 TNF 19951425 353238 Regulation IL13 TNF 20808962 2473165 Regulation IL15 IL1B 22020329 2144338 Regulation IL15 IL1R2 2143773 1563025 Regulation IL15 IL1R2 2664067 1577717 Regulation IL15 TNF 11219391 98346 Regulation IL15 TNF 20808962 2473166 Regulation IL15 TNF 21881590 1630503 Regulation IL15 TNF 23950892 2832724 Regulation IL15 TNF 24603712 2931985 Regulation IL16 ALOX5 12235216 1524882 Regulation IL16 IL1B 22020329 2144339 Regulation IL16 IL1R2 2143773 1563027 Regulation IL16 IL1R2 2664067 1577719 Regulation IL16 TNF 20808962 2473167 Regulation IL17A EPHB2 24376862 2902566 Regulation IL17A FOXO1 21825017 1564547 Regulation IL17A FOXO1 21825017 1564591 Regulation IL17A IFI27 21326316 988610 Regulation IL17A IFI27 21326316 988611 Regulation IL17A JAG1 24435677 809080 Regulation IL17A PTGER2 19273625 1554274 Regulation IL17A PTGER2 21946663 1041837 Regulation IL17A RORC 22473038 1957043 Regulation IL17A RORC 23626872 141966 Regulation IL17A RORC 24611151 588850 Regulation IL17A TLR7 20374638 328779 Regulation IL17A TLR7 22417709 125151 Regulation IL17A TLR7 24358364 2899771 Regulation IL17A TNF 15642134 102287 Regulation IL17A TNF 20571894 1491251 Regulation IL17A TNF 21078888 1561563 Regulation IL17A TNF 21078888 1561568 Regulation IL17A TNF 21801431 123396 Regulation IL17A TNF 23349929 2744083 Regulation IL17A TNF 24744681 3156523 Regulation IL17A TNF 24744681 3156528 Regulation IL17A ZBTB16 22473038 1957044 Regulation IL17D TLR7 22911108 3058879 Regulation IL18 IL1B 22020329 2144340 Regulation IL18 IL1R2 2143773 1563029 Regulation IL18 IL1R2 2664067 1577721 Regulation IL18 TLR7 18195076 1548601 Regulation IL18 TLR7 18195076 1548646 Regulation IL18 TLR7 23484118 179475 Regulation IL18 TLR7 23484118 179496 Regulation IL18 TNF 1396471 791931 Regulation IL18 TNF 15285802 1654729 Regulation IL18 TNF 20808962 2473168 Regulation IL18 TNF 25580276 1491717 Regulation IL19 IL1B 22020329 2144341 Regulation IL19 IL1R2 2143773 1563031 Regulation IL19 IL1R2 2664067 1577723 Regulation IL19 TNF 20808962 2473169 Regulation IL1A ADAMTS1 20645923 147939 Regulation IL1A AXIN2 10496353 415374 Regulation IL1A CAPN8 21978263 354776 Regulation IL1A CAPN8 22563421 2626439 Regulation IL1A CAPN8 24024155 3093359 Regulation IL1A CD14 20946675 1723296 Regulation IL1A CD14 20946675 1723297 Regulation IL1A CLU 25342887 743391 Regulation IL1A EPHB2 22114704 2573496 Regulation IL1A EPHB2 22867088 2233246 Regulation IL1A EPHB2 23209347 1750896 Regulation IL1A EPHB2 24349206 2897076 Regulation IL1A FOXO1 19651810 710724 Regulation IL1A FOXO1 19651810 710725 Regulation IL1A FOXO1 19651810 710726 Regulation IL1A FOXO1 19651810 710727 Regulation IL1A FOXO1 19651810 710728 Regulation IL1A FOXO1 19651810 710735 Regulation IL1A FOXO1 19651810 710742 Regulation IL1A FOXO1 19651810 710743 Regulation IL1A FOXO1 19651810 710760 Regulation IL1A FOXO1 19651810 710761 Regulation IL1A FOXO1 19651810 710766 Regulation IL1A FOXO1 19651810 710768 Regulation IL1A IL1B 23717664 2798687 Regulation IL1A IL1B 23717664 2798688 Regulation IL1A IL1R2 10637275 1514180 Regulation IL1A IL1R2 20847813 1747873 Regulation IL1A MMP28 11714393 98490 Regulation IL1A MMP28 23825438 178304 Regulation IL1A MMP7 11714393 98505 Regulation IL1A MMP7 23825438 178319 Regulation IL1A PLAU 23502002 2086205 Regulation IL1A PTGER2 25237386 1651020 Regulation IL1A SPHK1 20634980 2455712 Regulation IL1A SPHK1 21310085 1657773 Regulation IL1A TLR7 21085613 3050011 Regulation IL1A TLR7 21152080 2486103 Regulation IL1A TLR7 21188221 1081730 Regulation IL1A TLR7 21733175 1658673 Regulation IL1A TLR7 22164330 97571 Regulation IL1A TLR7 22484733 1957174 Regulation IL1A TLR7 22530722 3210220 Regulation IL1A TLR7 22649499 2646618 Regulation IL1A TLR7 22751696 723637 Regulation IL1A TLR7 22937165 2683165 Regulation IL1A TLR7 23239947 3229389 Regulation IL1A TLR7 23509682 179803 Regulation IL1A TLR7 23937571 357444 Regulation IL1A TLR7 24178712 3223569 Regulation IL1A TLR7 24285369 3138878 Regulation IL1A TLR7 24886384 3124695 Regulation IL1A TLR7 24942685 1043323 Regulation IL1A TLR7 24966466 1759801 Regulation IL1A TLR7 25071732 927045 Regulation IL1A TLR7 25136575 197190 Regulation IL1A TLR7 25340046 950144 Regulation IL1A TLR7 25485543 3032616 Regulation IL1A TLR7 PMC3194144 134707 Regulation IL1A TNF 16613612 105826 Regulation IL1A TNF 17177994 107709 Regulation IL1A TNF 18475483 1743987 Regulation IL1A TNF 19198593 1952250 Regulation IL1A TNF 20156727 809184 Regulation IL1A TNF 20693346 716065 Regulation IL1A TNF 20890434 1635297 Regulation IL1A TNF 21131967 1954736 Regulation IL1A TNF 21383912 176025 Regulation IL1A TNF 23136547 1084285 Regulation IL1A TNF 23509435 3154516 Regulation IL1A TNF 23940760 2832281 Regulation IL1A TNF 23940760 2832286 Regulation IL1A TNF 23940760 2832313 Regulation IL1A TNF 23940775 2832355 Regulation IL1A TNF 24156755 380451 Regulation IL1A TNF 24192345 295265 Regulation IL1A TNF 24594641 2929967 Regulation IL1A TNF 24595131 2930800 Regulation IL1A TNF 24747164 18904 Regulation IL1A TNF 24864134 1758839 Regulation IL1A TNF 24982891 193529 Regulation IL1A TNF 25501329 1135636 Regulation IL1A TNF 25580276 1491718 Regulation IL1A TNF 25614712 1763571 Regulation IL1A TNF 2647895 1577616 Regulation IL1B ADAM17 22792188 2661289 Regulation IL1B BMP7 19011694 2400858 Regulation IL1B BMP7 19011694 2400867 Regulation IL1B BMP7 19011694 2400874 Regulation IL1B CASP1 24312444 2889502 Regulation IL1B CASP1 24972036 2985206 Regulation IL1B CASP10 24972036 2985207 Regulation IL1B CASP12 24972036 2985217 Regulation IL1B CASP14 24972036 2985208 Regulation IL1B CASP16 24972036 2985218 Regulation IL1B CASP2 24972036 2985209 Regulation IL1B CASP3 24972036 2985210 Regulation IL1B CASP4 24972036 2985211 Regulation IL1B CASP5 24972036 2985212 Regulation IL1B CASP6 24972036 2985213 Regulation IL1B CASP7 24972036 2985214 Regulation IL1B CASP8 24972036 2985215 Regulation IL1B CASP9 24972036 2985216 Regulation IL1B CDK9 24009751 2841598 Regulation IL1B CFTR 23977375 2840149 Regulation IL1B EDN1 19954533 2232849 Regulation IL1B EGFR 22792188 2661230 Regulation IL1B EGFR 22792188 2661259 Regulation IL1B ENTPD1 18553155 3089823 Regulation IL1B FCGR3A 22184119 1200869 Regulation IL1B HLA-A 16162034 2368500 Regulation IL1B IL10 15154610 630085 Regulation IL1B IL10 22020329 2144352 Regulation IL1B IL11 22020329 2144353 Regulation IL1B IL13 22020329 2144354 Regulation IL1B IL15 12857602 1738973 Regulation IL1B IL15 22020329 2144355 Regulation IL1B IL16 22020329 2144356 Regulation IL1B IL18 22020329 2144357 Regulation IL1B IL19 22020329 2144358 Regulation IL1B IL1A 23516523 2768209 Regulation IL1B IL1RN 23451225 2758408 Regulation IL1B IL2 22020329 2144359 Regulation IL1B IL20 22020329 2144360 Regulation IL1B IL21 22020329 2144361 Regulation IL1B IL22 22020329 2144344 Regulation IL1B IL24 22020329 2144342 Regulation IL1B IL25 22020329 2144343 Regulation IL1B IL26 22020329 2144348 Regulation IL1B IL27 22020329 2144349 Regulation IL1B IL3 22020329 2144362 Regulation IL1B IL31 22020329 2144350 Regulation IL1B IL32 22020329 2144347 Regulation IL1B IL33 22020329 2144346 Regulation IL1B IL34 22020329 2144351 Regulation IL1B IL37 22020329 2144345 Regulation IL1B IL4 22020329 2144363 Regulation IL1B IL5 22020329 2144364 Regulation IL1B IL6 22020329 2144365 Regulation IL1B IL6 22229105 1082427 Regulation IL1B IL6ST 24009751 2841599 Regulation IL1B IL7 22020329 2144366 Regulation IL1B IL8 22020329 2144367 Regulation IL1B IL8 22701308 1224382 Regulation IL1B IL9 22020329 2144368 Regulation IL1B LCN2 23776639 2805350 Regulation IL1B MAP3K7 20680494 1654491 Regulation IL1B MAPK1 19094210 112270 Regulation IL1B MAPK10 19094210 112271 Regulation IL1B MAPK11 19094210 112272 Regulation IL1B MAPK12 19094210 112273 Regulation IL1B MAPK13 19094210 112274 Regulation IL1B MAPK14 19094210 112275 Regulation IL1B MAPK15 19094210 112269 Regulation IL1B MAPK3 19094210 112276 Regulation IL1B MAPK4 19094210 112277 Regulation IL1B MAPK6 19094210 112278 Regulation IL1B MAPK7 19094210 112279 Regulation IL1B MAPK8 19094210 112280 Regulation IL1B MAPK9 19094210 112281 Regulation IL1B MIR146A 21694443 736914 Regulation IL1B NFKB1 24009751 2841600 Regulation IL1B NFKB1 8642348 1596998 Regulation IL1B NFKB1 9839693 1764072 Regulation IL1B NLRP12 PMC3194427 2236098 Regulation IL1B NLRP3 21740493 590607 Regulation IL1B NOTCH1 19094210 112282 Regulation IL1B NOTCH2 19094210 112283 Regulation IL1B NOTCH3 19094210 112284 Regulation IL1B NOTCH4 19094210 112285 Regulation IL1B P2RX7 24972036 2985219 Regulation IL1B PGD 19094210 112286 Regulation IL1B PPARA 19011694 2400859 Regulation IL1B PPARA 19011694 2400875 Regulation IL1B PTGS1 9927229 1764290 Regulation IL1B RELA 24009751 2841601 Regulation IL1B RELA 8642348 1596999 Regulation IL1B RELA 9839693 1764073 Regulation IL1B SIRT1 19008341 707279 Regulation IL1B SOD2 24885568 365029 Regulation IL1B SPI1 23936458 2831020 Regulation IL1B TLR1 PMC3952087 2236180 Regulation IL1B TLR10 PMC3952087 2236188 Regulation IL1B TLR2 PMC3952087 2236181 Regulation IL1B TLR3 PMC3952087 2236182 Regulation IL1B TLR4 23936458 2831025 Regulation IL1B TLR4 24755298 1668084 Regulation IL1B TLR4 PMC3952087 2236183 Regulation IL1B TLR5 PMC3952087 2236184 Regulation IL1B TLR6 PMC3952087 2236189 Regulation IL1B TLR7 PMC3952087 2236185 Regulation IL1B TLR8 PMC3952087 2236186 Regulation IL1B TLR9 PMC3952087 2236187 Regulation IL1B TNF 16571116 1624905 Regulation IL1B TNF 21569399 1697254 Regulation IL1B TNF 21569399 1697259 Regulation IL1B TNF 24156755 380452 Regulation IL1B UGT8 16098232 1727719 Regulation IL1B UGT8 16098232 1727720 Regulation IL1R1 IL1B 22642771 1662991 Regulation IL1R1 TLR7 18268042 1549438 Regulation IL1R2 IL10 2143773 1563069 Regulation IL1R2 IL10 2664067 1577761 Regulation IL1R2 IL11 2143773 1563070 Regulation IL1R2 IL11 2664067 1577762 Regulation IL1R2 IL13 2143773 1563071 Regulation IL1R2 IL13 2664067 1577763 Regulation IL1R2 IL15 2143773 1563072 Regulation IL1R2 IL15 2664067 1577764 Regulation IL1R2 IL16 2143773 1563073 Regulation IL1R2 IL16 2664067 1577765 Regulation IL1R2 IL18 2143773 1563074 Regulation IL1R2 IL18 2664067 1577766 Regulation IL1R2 IL19 2143773 1563075 Regulation IL1R2 IL19 2664067 1577767 Regulation IL1R2 IL1A 18472818 1741828 Regulation IL1R2 IL1A 2965211 1579227 Regulation IL1R2 IL2 2143773 1563076 Regulation IL1R2 IL2 2664067 1577768 Regulation IL1R2 IL20 2143773 1563077 Regulation IL1R2 IL20 2664067 1577769 Regulation IL1R2 IL21 2143773 1563078 Regulation IL1R2 IL21 2664067 1577770 Regulation IL1R2 IL22 2143773 1563061 Regulation IL1R2 IL22 2664067 1577753 Regulation IL1R2 IL24 2143773 1563059 Regulation IL1R2 IL24 2664067 1577751 Regulation IL1R2 IL25 2143773 1563060 Regulation IL1R2 IL25 2664067 1577752 Regulation IL1R2 IL26 2143773 1563065 Regulation IL1R2 IL26 2664067 1577757 Regulation IL1R2 IL27 2143773 1563066 Regulation IL1R2 IL27 2664067 1577758 Regulation IL1R2 IL3 2143773 1563079 Regulation IL1R2 IL3 2664067 1577771 Regulation IL1R2 IL31 2143773 1563067 Regulation IL1R2 IL31 2664067 1577759 Regulation IL1R2 IL32 2143773 1563064 Regulation IL1R2 IL32 2664067 1577756 Regulation IL1R2 IL33 2143773 1563063 Regulation IL1R2 IL33 2664067 1577755 Regulation IL1R2 IL34 2143773 1563068 Regulation IL1R2 IL34 2664067 1577760 Regulation IL1R2 IL37 2143773 1563062 Regulation IL1R2 IL37 2664067 1577754 Regulation IL1R2 IL4 2143773 1563080 Regulation IL1R2 IL4 2664067 1577772 Regulation IL1R2 IL5 2143773 1563081 Regulation IL1R2 IL5 2664067 1577773 Regulation IL1R2 IL6 2143773 1563082 Regulation IL1R2 IL6 2664067 1577774 Regulation IL1R2 IL7 2143773 1563083 Regulation IL1R2 IL7 2664067 1577775 Regulation IL1R2 IL8 2143773 1563084 Regulation IL1R2 IL8 2664067 1577776 Regulation IL1R2 IL9 2143773 1563085 Regulation IL1R2 IL9 2664067 1577777 Regulation IL1RL1 ATF3 22390138 150064 Regulation IL1RL1 IL4 24832045 176608 Regulation IL1RL1 STAT6 24832045 176607 Regulation IL1RN ANGPT1 24563688 2923998 Regulation IL1RN TNF 1386877 1528872 Regulation IL1RN TNF 15142263 101157 Regulation IL1RN TNF 23577023 3076685 Regulation IL1RN TNF PMC2833622 134246 Regulation IL2 CD14 10587349 1513470 Regulation IL2 CD14 23898465 864146 Regulation IL2 EPHB2 15833106 3104963 Regulation IL2 EPHB2 21989417 1041865 Regulation IL2 EPHB2 22769588 521320 Regulation IL2 FAS 11104808 1518118 Regulation IL2 FAS 23391314 1049252 Regulation IL2 IL1B 22020329 2144369 Regulation IL2 IL1R2 2143773 1563087 Regulation IL2 IL1R2 2664067 1577779 Regulation IL2 ITGB2 1717633 1543747 Regulation IL2 ITGB2 23864893 821538 Regulation IL2 JAG1 2965740 1579439 Regulation IL2 LAMB3 9971749 1474245 Regulation IL2 LBP 25552899 744135 Regulation IL2 MAP2K6 10544198 1512887 Regulation IL2 MIP 22132075 2573992 Regulation IL2 STAT4 20104254 1910517 Regulation IL2 TLR7 22984435 2688631 Regulation IL2 TNF 2056282 1558509 Regulation IL2 TNF 20808962 2473170 Regulation IL2 TNF 2109037 1561575 Regulation IL2 TNF 21915344 2553425 Regulation IL2 TNF 22132075 2573988 Regulation IL2 TNF 22216206 2584611 Regulation IL20 IL1B 22020329 2144370 Regulation IL20 IL1R2 2143773 1563089 Regulation IL20 IL1R2 2664067 1577781 Regulation IL20 TNF 20808962 2473171 Regulation IL20 TNF PMC2833708 134306 Regulation IL21 IL1B 22020329 2144371 Regulation IL21 IL1R2 2143773 1563091 Regulation IL21 IL1R2 2664067 1577783 Regulation IL21 STAT4 22848667 2670015 Regulation IL21 STAT4 23064011 30905 Regulation IL21 STAT4 23064011 30914 Regulation IL21 STAT4 23064011 30915 Regulation IL21 TNF 20808962 2473172 Regulation IL22 CD14 23131784 1919436 Regulation IL22 CD14 23131784 1919437 Regulation IL22 CD14 23131784 1919475 Regulation IL22 FOXO1 21825017 1564545 Regulation IL22 FOXO1 21825017 1564588 Regulation IL22 IL1B 22020329 2144327 Regulation IL22 IL1R2 2143773 1563003 Regulation IL22 IL1R2 2664067 1577695 Regulation IL22 RAB31 22417743 125269 Regulation IL22 TLR7 24358364 2899758 Regulation IL22 TNF 20808962 2473155 Regulation IL22 TNF 24623532 1050584 Regulation IL23A RORC 23469228 2763571 Regulation IL23A TLR7 18490488 1551228 Regulation IL23A TLR7 21188221 1081710 Regulation IL23A TLR7 22164330 97569 Regulation IL23A TLR7 22417709 125122 Regulation IL23A TLR7 23755218 2802038 Regulation IL23A TLR7 23940256 1573367 Regulation IL23A TLR7 23967307 2835808 Regulation IL23A TLR7 23967307 2836144 Regulation IL23A TNF 15657292 1534265 Regulation IL23A TNF 21881590 1630501 Regulation IL23A TNF 21881590 1630502 Regulation IL23A TNF 22545055 1144851 Regulation IL23A TNF 22545055 1144855 Regulation IL24 IL1B 22020329 2144325 Regulation IL24 IL1R2 2143773 1562999 Regulation IL24 IL1R2 2664067 1577691 Regulation IL24 TNF 20808962 2473153 Regulation IL25 IL1B 22020329 2144326 Regulation IL25 IL1R2 2143773 1563001 Regulation IL25 IL1R2 2664067 1577693 Regulation IL25 TNF 20808962 2473154 Regulation IL26 IL1B 22020329 2144331 Regulation IL26 IL1R2 2143773 1563011 Regulation IL26 IL1R2 2664067 1577703 Regulation IL26 TNF 20808962 2473159 Regulation IL27 IL1B 22020329 2144332 Regulation IL27 IL1R2 2143773 1563013 Regulation IL27 IL1R2 2664067 1577705 Regulation IL27 TNF 20808962 2473160 Regulation IL2RA EPHB2 23758320 151545 Regulation IL2RA MMP28 19509016 708909 Regulation IL2RA MMP7 19509016 708924 Regulation IL2RA TLR7 17283209 1544285 Regulation IL2RA TNF 2831292 1578483 Regulation IL2RA TNF 7836916 1592460 Regulation IL2RB TNF 19570027 137314 Regulation IL2RB TNF 19570027 137315 Regulation IL2RB TNF 19570027 137412 Regulation IL2RB TNF 21519548 85481 Regulation IL3 IL1B 22020329 2144372 Regulation IL3 IL1R2 2143773 1563093 Regulation IL3 IL1R2 2664067 1577785 Regulation IL3 TNF 20808962 2473173 Regulation IL3 TNF 8439496 444904 Regulation IL3 TNF 8879191 1599074 Regulation IL31 IL1B 22020329 2144333 Regulation IL31 IL1R2 2143773 1563015 Regulation IL31 IL1R2 2664067 1577707 Regulation IL31 TNF 20808962 2473161 Regulation IL32 IL1B 22020329 2144330 Regulation IL32 IL1R2 2143773 1563009 Regulation IL32 IL1R2 2664067 1577701 Regulation IL32 TNF 20615213 119660 Regulation IL32 TNF 20615213 119661 Regulation IL32 TNF 20615213 119662 Regulation IL32 TNF 20615213 119663 Regulation IL32 TNF 20615213 119669 Regulation IL32 TNF 20615213 119673 Regulation IL32 TNF 20615213 119703 Regulation IL32 TNF 20808962 2473158 Regulation IL33 CAPN8 22778496 1750034 Regulation IL33 IL1B 22020329 2144329 Regulation IL33 IL1R2 2143773 1563007 Regulation IL33 IL1R2 2664067 1577699 Regulation IL33 TLR7 23169007 808719 Regulation IL33 TLR7 24058536 2847891 Regulation IL33 TNF 20808962 2473157 Regulation IL33 TNF 23418608 2754908 Regulation IL33 TNF 23567618 1642606 Regulation IL33 TNF 23567618 1642622 Regulation IL33 TNF 23567618 1642623 Regulation IL34 FUT4 23409120 2753570 Regulation IL34 IL1B 22020329 2144334 Regulation IL34 IL1R2 2143773 1563017 Regulation IL34 IL1R2 2664067 1577709 Regulation IL34 TNF 20808962 2473162 Regulation IL34 TNF 24339952 2894354 Regulation IL34 TNF 24339952 2894355 Regulation IL34 TNF 24339952 2894356 Regulation IL34 TNF 24339952 2894361 Regulation IL34 TNF 24970360 1886466 Regulation IL36B TNF 16646978 105917 Regulation IL37 IL1B 22020329 2144328 Regulation IL37 IL1R2 2143773 1563005 Regulation IL37 IL1R2 2664067 1577697 Regulation IL37 TNF 20808962 2473156 Regulation IL4 ALOX5 12235216 1524884 Regulation IL4 ARSA 21829647 2542227 Regulation IL4 EPHB2 16172258 1537806 Regulation IL4 EPHB2 21989417 1041851 Regulation IL4 EPHB2 21989417 1041852 Regulation IL4 EPHB2 21989417 1041853 Regulation IL4 EPHB2 21989417 1041854 Regulation IL4 EPHB2 21989417 1041855 Regulation IL4 EPHB2 21989417 1041866 Regulation IL4 EPHB2 22130674 1200743 Regulation IL4 IL1B 22020329 2144373 Regulation IL4 IL1R2 2143773 1563095 Regulation IL4 IL1R2 2664067 1577787 Regulation IL4 RORC 22473038 1957046 Regulation IL4 STAT4 17030948 1542813 Regulation IL4 TLR7 23194300 356096 Regulation IL4 TNF 20808962 2473174 Regulation IL4 TNF 22132075 2573996 Regulation IL4 TNF 24550673 1138204 Regulation IL4 TNF 8691152 1598574 Regulation IL4 ZBTB16 22473038 1957047 Regulation IL4I1 RORC 24151516 638704 Regulation IL5 EPHB2 22783258 902428 Regulation IL5 IL1B 11132773 1737259 Regulation IL5 IL1B 22020329 2144374 Regulation IL5 IL1R2 2143773 1563097 Regulation IL5 IL1R2 2664067 1577789 Regulation IL5 TNF 11132773 1737258 Regulation IL5 TNF 20808962 2473175 Regulation IL6 ARSA 23306703 835014 Regulation IL6 ARSA 23306703 835015 Regulation IL6 ARSA 23306703 835023 Regulation IL6 CD14 20946675 1723302 Regulation IL6 CD14 20946675 1723303 Regulation IL6 CD14 7500012 1587100 Regulation IL6 CTGF 23227240 2725716 Regulation IL6 EDN2 18195069 1548359 Regulation IL6 EDN2 18195069 1548400 Regulation IL6 EDN2 18195069 1548401 Regulation IL6 EDN2 20937084 1657177 Regulation IL6 EPHB2 18310089 505551 Regulation IL6 EPHB2 21054880 508254 Regulation IL6 EPHB2 21162728 2232990 Regulation IL6 EPHB2 22537317 355871 Regulation IL6 EPHB2 22736938 1914558 Regulation IL6 EPHB2 23343403 127791 Regulation IL6 EPHB2 23405061 2751550 Regulation IL6 EPHB2 23554896 2773620 Regulation IL6 EPHB2 24191131 1754981 Regulation IL6 EPHB2 24191131 1754991 Regulation IL6 EPHB2 24566135 1124040 Regulation IL6 EPHB2 24782592 1758332 Regulation IL6 EPHB2 24913620 391447 Regulation IL6 EPHB2 25192391 3005508 Regulation IL6 FAS 20956499 716765 Regulation IL6 FAS 23305094 1725208 Regulation IL6 GPR115 16951492 1740494 Regulation IL6 GPR132 16951492 1740483 Regulation IL6 GPR87 16951492 1740563 Regulation IL6 HRH1 25374757 82624 Regulation IL6 ID1 20010941 434214 Regulation IL6 ID1 20010941 434218 Regulation IL6 IL1B 22020329 2144375 Regulation IL6 IL1B 22611374 833062 Regulation IL6 IL1B 22611374 833066 Regulation IL6 IL1R2 2143773 1563099 Regulation IL6 IL1R2 2664067 1577791 Regulation IL6 LINC00284 25431574 916013 Regulation IL6 LINC00284 25431574 920188 Regulation IL6 LINC00341 25431574 915973 Regulation IL6 LINC00341 25431574 920148 Regulation IL6 MAP2K6 10544198 1512894 Regulation IL6 MAP2K6 21054880 508263 Regulation IL6 MAP2K6 21521520 122420 Regulation IL6 MAP2K6 24855454 1627879 Regulation IL6 MAP2K6 25231749 1142737 Regulation IL6 NT5E 23520507 2768961 Regulation IL6 PGC 23240005 2727176 Regulation IL6 PLAT 23408962 2753001 Regulation IL6 RNASE1 21953341 90941 Regulation IL6 RNASE7 21953341 90949 Regulation IL6 STK39 20552019 2452802 Regulation IL6 TLR7 17485511 1545696 Regulation IL6 TLR7 17485512 1545951 Regulation IL6 TLR7 17895997 2378784 Regulation IL6 TLR7 17998391 1547791 Regulation IL6 TLR7 18066067 1951744 Regulation IL6 TLR7 19047436 1552989 Regulation IL6 TLR7 19430534 2416273 Regulation IL6 TLR7 19668221 1952780 Regulation IL6 TLR7 19770272 1556401 Regulation IL6 TLR7 19806220 2427841 Regulation IL6 TLR7 20584912 1377139 Regulation IL6 TLR7 21115688 1562053 Regulation IL6 TLR7 21115688 1562065 Regulation IL6 TLR7 21789039 979944 Regulation IL6 TLR7 21829730 2542604 Regulation IL6 TLR7 21953341 90983 Regulation IL6 TLR7 21994612 3218988 Regulation IL6 TLR7 22164330 97572 Regulation IL6 TLR7 22484733 1957153 Regulation IL6 TLR7 22751696 723647 Regulation IL6 TLR7 22751696 723732 Regulation IL6 TLR7 22751696 723733 Regulation IL6 TLR7 22883744 1664745 Regulation IL6 TLR7 23071254 1569731 Regulation IL6 TLR7 23239947 3229399 Regulation IL6 TLR7 24178712 3223570 Regulation IL6 TLR7 24282429 639180 Regulation IL6 TLR7 24505352 2920707 Regulation IL6 TLR7 24886842 2975728 Regulation IL6 TLR7 25112836 1619113 Regulation IL6 TLR7 25136575 197191 Regulation IL6 TLR7 25276832 200425 Regulation IL6 TLR7 PMC3194144 134717 Regulation IL6 TNF 12482999 1633953 Regulation IL6 TNF 12823853 99849 Regulation IL6 TNF 1373292 423501 Regulation IL6 TNF 15574198 3177974 Regulation IL6 TNF 15642135 102294 Regulation IL6 TNF 15642135 102301 Regulation IL6 TNF 16008840 3105107 Regulation IL6 TNF 16185356 3105674 Regulation IL6 TNF 16185356 3105679 Regulation IL6 TNF 16185356 3105691 Regulation IL6 TNF 18234077 110112 Regulation IL6 TNF 18434350 1497482 Regulation IL6 TNF 18472819 1741837 Regulation IL6 TNF 18475475 1743894 Regulation IL6 TNF 18475489 1744021 Regulation IL6 TNF 18475629 1744948 Regulation IL6 TNF 18475825 1767022 Regulation IL6 TNF 18955281 811114 Regulation IL6 TNF 20150970 1213780 Regulation IL6 TNF 20224659 1214046 Regulation IL6 TNF 20380722 118656 Regulation IL6 TNF 20808962 2473176 Regulation IL6 TNF 20827340 2114612 Regulation IL6 TNF 20830230 1711867 Regulation IL6 TNF 20877569 2475385 Regulation IL6 TNF 20953899 645856 Regulation IL6 TNF 21152179 1028877 Regulation IL6 TNF 21245598 91583 Regulation IL6 TNF 21253506 1748721 Regulation IL6 TNF 21306632 2233028 Regulation IL6 TNF 21383912 176026 Regulation IL6 TNF 21394207 2506560 Regulation IL6 TNF 21629785 2525655 Regulation IL6 TNF 21687569 661407 Regulation IL6 TNF 22125453 3152140 Regulation IL6 TNF 22190977 633832 Regulation IL6 TNF 22190977 633841 Regulation IL6 TNF 22547990 3152642 Regulation IL6 TNF 22606066 3152815 Regulation IL6 TNF 22611374 833061 Regulation IL6 TNF 22611374 833065 Regulation IL6 TNF 23104095 1958306 Regulation IL6 TNF 23104095 1958307 Regulation IL6 TNF 23285227 2733020 Regulation IL6 TNF 23363614 127889 Regulation IL6 TNF 23363614 127892 Regulation IL6 TNF 23363614 127893 Regulation IL6 TNF 23469058 2760942 Regulation IL6 TNF 23956643 1920757 Regulation IL6 TNF 24062615 1628899 Regulation IL6 TNF 24138989 410765 Regulation IL6 TNF 24244348 2879478 Regulation IL6 TNF 24286116 130147 Regulation IL6 TNF 24286116 130158 Regulation IL6 TNF 24339952 2894367 Regulation IL6 TNF 24455710 186343 Regulation IL6 TNF 24505395 2920780 Regulation IL6 TNF 24747164 18908 Regulation IL6 TNF 24758719 1483139 Regulation IL6 TNF 25126586 1622999 Regulation IL6 TNF 25400932 1037366 Regulation IL6 TNF 25479553 3032323 Regulation IL6 TNF 25501329 1135637 Regulation IL6 TNF 7530764 1589991 Regulation IL6 TNF 7530764 1590009 Regulation IL6 TNF 7577463 444043 Regulation IL6 TNF 7595192 1590717 Regulation IL6 TNF 7595192 1590718 Regulation IL6 TNF 7964502 1593661 Regulation IL6 TNF 9400742 797443 Regulation IL6 TNF 9788898 798146 Regulation IL6 TNF 9788898 798147 Regulation IL6 TNF 9788898 798148 Regulation IL6 TNF 9864375 1473486 Regulation IL6 TNF PMC3952452 2236259 Regulation IL6 TNF PMC3952452 2236261 Regulation IL6 TNF PMC4033969 2245918 Regulation IL6 TNF PMC4291585 541135 Regulation IL6R B4GALT1 24146813 2868171 Regulation IL6R CD24 19014460 361919 Regulation IL6R IL6ST 20462429 402595 Regulation IL6R MPL 24312573 2889870 Regulation IL6R MYLIP 22942733 1097144 Regulation IL6ST EDN2 18195069 1548456 Regulation IL7 FOXO1 22654881 901226 Regulation IL7 IL1B 22020329 2144376 Regulation IL7 IL1R2 2143773 1563101 Regulation IL7 IL1R2 2664067 1577793 Regulation IL7 TNF 20808962 2473177 Regulation IL7 TNF 23136547 1084294 Regulation IL7 TNF 24562309 1959956 Regulation IL7R MAML3 19349467 1554439 Regulation IL7R MAML3 19349467 1554480 Regulation IL8 ALOX5 18475524 1744200 Regulation IL8 ANO1 22973054 1807577 Regulation IL8 ANO1 22973054 1807585 Regulation IL8 ANO1 22973054 1807589 Regulation IL8 CCND1 24086675 2855503 Regulation IL8 CD14 17242961 810109 Regulation IL8 EPHB2 19279691 1909018 Regulation IL8 EPHB2 20051107 365722 Regulation IL8 EPHB2 20051107 365723 Regulation IL8 EPHB2 21192810 366208 Regulation IL8 EPHB2 21789185 2538095 Regulation IL8 EPHB2 21860608 1038260 Regulation IL8 EPHB2 22719918 2653751 Regulation IL8 EPHB2 22867088 2233256 Regulation IL8 EPHB2 22867088 2233316 Regulation IL8 EPHB2 23034049 3113205 Regulation IL8 EPHB2 24629040 1701550 Regulation IL8 EPHB2 24647471 2936142 Regulation IL8 EPHB2 25121739 2997348 Regulation IL8 HBEGF 24555532 3114322 Regulation IL8 IL1B 18553155 3090101 Regulation IL8 IL1B 22020329 2144377 Regulation IL8 IL1R2 2143773 1563103 Regulation IL8 IL1R2 2664067 1577795 Regulation IL8 ITGB2 8691134 1598410 Regulation IL8 LBP 21352551 1626322 Regulation IL8 LBP 21352551 1626323 Regulation IL8 LBP 21352551 1626324 Regulation IL8 LBP 21352551 1626326 Regulation IL8 LBP 21352551 1626328 Regulation IL8 LINC00284 25431574 920785 Regulation IL8 LINC00341 25431574 920745 Regulation IL8 MIP 21931324 1720404 Regulation IL8 NT5E 25242873 1762329 Regulation IL8 RCAN1 19348862 158349 Regulation IL8 RCAN1 19819266 158548 Regulation IL8 RCAN1 19819266 158549 Regulation IL8 RCAN1 19819266 158574 Regulation IL8 S100A7 22230654 3112898 Regulation IL8 TLR7 19527497 3109664 Regulation IL8 TLR7 20584912 1377149 Regulation IL8 TLR7 21108806 1626209 Regulation IL8 TLR7 22216191 2584559 Regulation IL8 TLR7 22558189 2624564 Regulation IL8 TLR7 23497095 2236050 Regulation IL8 TLR7 23824215 2808908 Regulation IL8 TLR7 23950714 3063610 Regulation IL8 TLR7 24164922 399428 Regulation IL8 TLR7 24164922 399450 Regulation IL8 TLR7 24285369 3138888 Regulation IL8 TLR7 25276832 200435 Regulation IL8 TLR7 PMC3194144 134728 Regulation IL8 TNF 11686888 3103512 Regulation IL8 TNF 11879548 98697 Regulation IL8 TNF 11879548 98698 Regulation IL8 TNF 11879548 98699 Regulation IL8 TNF 12482999 1633955 Regulation IL8 TNF 12823853 99852 Regulation IL8 TNF 15857511 648856 Regulation IL8 TNF 16008840 3105104 Regulation IL8 TNF 16185356 3105676 Regulation IL8 TNF 16185356 3105677 Regulation IL8 TNF 16185356 3105681 Regulation IL8 TNF 16185356 3105682 Regulation IL8 TNF 17620405 1341847 Regulation IL8 TNF 18321393 356786 Regulation IL8 TNF 18472819 1741839 Regulation IL8 TNF 18472842 1742221 Regulation IL8 TNF 18475825 1767023 Regulation IL8 TNF 19014534 2232752 Regulation IL8 TNF 19014534 2232753 Regulation IL8 TNF 19014534 2232754 Regulation IL8 TNF 19014534 2232774 Regulation IL8 TNF 19014534 2232780 Regulation IL8 TNF 19308690 495330 Regulation IL8 TNF 19487419 1554847 Regulation IL8 TNF 19503841 1746617 Regulation IL8 TNF 20803037 3175157 Regulation IL8 TNF 20808962 2473178 Regulation IL8 TNF 20830230 1711869 Regulation IL8 TNF 21092318 1626189 Regulation IL8 TNF 21346178 718093 Regulation IL8 TNF 22363592 2601130 Regulation IL8 TNF 22414102 682236 Regulation IL8 TNF 22534338 398569 Regulation IL8 TNF 22891766 245234 Regulation IL8 TNF 22899878 1750212 Regulation IL8 TNF 22988345 1750569 Regulation IL8 TNF 23189190 2722344 Regulation IL8 TNF 23251142 3076086 Regulation IL8 TNF 23326019 1751342 Regulation IL8 TNF 23800251 1627040 Regulation IL8 TNF 23800251 1627041 Regulation IL8 TNF 23800251 1627100 Regulation IL8 TNF 23800251 1627101 Regulation IL8 TNF 23800251 1627113 Regulation IL8 TNF 23800251 1627114 Regulation IL8 TNF 23800251 1627115 Regulation IL8 TNF 23800251 1627129 Regulation IL8 TNF 23800251 1627151 Regulation IL8 TNF 23800251 1627152 Regulation IL8 TNF 23823136 2808709 Regulation IL8 TNF 23841502 367171 Regulation IL8 TNF 23935691 822212 Regulation IL8 TNF 23967134 2834607 Regulation IL8 TNF 24086143 2350914 Regulation IL8 TNF 24517278 131794 Regulation IL8 TNF 24517278 131795 Regulation IL8 TNF 24517278 131847 Regulation IL8 TNF 24517278 131861 Regulation IL8 TNF 24864134 1758840 Regulation IL8 TNF 24892615 653900 Regulation IL8 TNF 24936153 1627920 Regulation IL8 TNF 25013674 1143399 Regulation IL8 TNF 7500047 1588528 Regulation IL8 TNF 8064229 1593933 Regulation IL8 TNF 9839698 1764091 Regulation IL8 TNF PMC4033969 2245919 Regulation IL9 IL1B 22020329 2144378 Regulation IL9 IL1R2 2143773 1563105 Regulation IL9 IL1R2 2664067 1577797 Regulation IL9 TNF 20808962 2473179 Regulation INHBA CCND1 24628936 539620 Regulation INHBA TNF 24899891 1074254 Regulation INHBB CNP 17374144 299879 Regulation INPP4B EPHB2 22895072 478779 Regulation INPP4B EPHB2 22895072 478787 Regulation INPP4B EPHB2 22895072 478806 Regulation INS ALDH2 22524197 358555 Regulation INS ANO1 24885604 359399 Regulation INS CD14 20064776 793859 Regulation INS ENPP1 21573217 2522972 Regulation INS ENPP1 21573217 2522976 Regulation INS ENPP1 23861746 2819804 Regulation INS ENPP1 24633815 3081937 Regulation INS EPHB2 19720798 711026 Regulation INS EPHB2 22745639 1068554 Regulation INS EPHB2 22875989 1806422 Regulation INS EPHB2 22875989 1806423 Regulation INS EPHB2 22875989 1806424 Regulation INS FAS 22676303 1724636 Regulation INS FAS 23258903 725429 Regulation INS FAS 24275630 1158362 Regulation INS FOXO1 21335550 1190781 Regulation INS FOXO1 21335550 1190782 Regulation INS FOXO1 21335550 1190786 Regulation INS FOXO1 21335550 1190799 Regulation INS FOXO1 21483870 2512517 Regulation INS FOXO1 22586579 722756 Regulation INS FOXO1 23606925 2225799 Regulation INS FOXO1 23885240 961974 Regulation INS FOXO1 24244124 2298994 Regulation INS FOXO1 24843627 1494187 Regulation INS FOXO1 24843827 589711 Regulation INS FOXO1 24904417 954472 Regulation INS FOXO1 25353004 1888791 Regulation INS G0S2 23951308 2834135 Regulation INS GLP1R 19859570 1213168 Regulation INS GLP1R 22101168 13932 Regulation INS GLP1R 22101168 13933 Regulation INS GLP1R 22101168 13934 Regulation INS GLP1R 22101168 13937 Regulation INS GLP1R 22101168 13938 Regulation INS GLP1R 22101168 13939 Regulation INS GLP1R 22776039 731754 Regulation INS GLP1R 23649520 727269 Regulation INS GLP1R 23815892 294441 Regulation INS GLP1R 24167617 2872397 Regulation INS GLP1R 24244813 204880 Regulation INS GLP1R 24951252 3126071 Regulation INS GLP1R 25206841 2006113 Regulation INS GLP1R 25309791 788266 Regulation INS GLP1R 25506055 201749 Regulation INS ID1 21940780 720683 Regulation INS ID1 21940780 720684 Regulation INS ID1 21940780 720689 Regulation INS ID1 21949000 720840 Regulation INS IGFBP1 17662149 108831 Regulation INS IGFBP1 18596909 2391657 Regulation INS IGFBP1 22357965 721624 Regulation INS IGFBP1 22950808 266231 Regulation INS IGFBP1 24204984 2875086 Regulation INS IGFBP1 25245338 1498072 Regulation INS PGC 20433743 2112653 Regulation INS RASD1 24817889 1070773 Regulation INS STAT4 23939393 728371 Regulation INS TGM2 1356992 1297658 Regulation INS TGM2 19859528 2269636 Regulation INS TGM2 24349085 2896744 Regulation INS TLR7 21151908 2485333 Regulation INS TLR7 24758278 1726883 Regulation INS TNF 19148295 1746430 Regulation INS TNF 19690064 710940 Regulation INS TNF 20007934 712159 Regulation INS TNF 21346178 718085 Regulation INS TNF 21346178 718086 Regulation INS TNF 22550485 1072973 Regulation INS TNF 22691241 126153 Regulation INS TNF 23056223 2700725 Regulation INS TNF 23176569 732212 Regulation INS TNF 24349514 2898386 Regulation INS TNF 24692847 1757851 Regulation INS TNF 24692847 1757854 Regulation INS TNF 24692847 1757856 Regulation INS TNF 25258478 1762463 Regulation INS TNF 25352752 1917462 Regulation INS TNF 25352752 1917496 Regulation INS TNF 7530759 1589911 Regulation INSR FOXO1 23844554 473479 Regulation INSR TNF 22654787 875806 Regulation INSR TNF 25352752 1917463 Regulation INTS1 EPHB2 22131969 860774 Regulation INTS10 EPHB2 22131969 860777 Regulation INTS12 EPHB2 22131969 860776 Regulation INTS2 EPHB2 22131969 860782 Regulation INTS2 TNF 22413919 508908 Regulation INTS2 TNF 24791061 1694377 Regulation INTS3 EPHB2 22131969 860781 Regulation INTS4 EPHB2 22131969 860775 Regulation INTS5 EPHB2 22131969 860783 Regulation INTS6 EPHB2 22131969 860772 Regulation INTS6 MAP2K6 17895999 2378795 Regulation INTS7 EPHB2 22131969 860773 Regulation INTS8 EPHB2 22131969 860779 Regulation INTS9 EPHB2 22131969 860778 Regulation IRAK1 TLR7 17485511 1545778 Regulation IRAK1 TLR7 21573018 2520473 Regulation IRAK1 TLR7 21743479 1955565 Regulation IRAK1 TNF 12493069 658440 Regulation IRAK1 TNF 23104095 1958281 Regulation IRAK1 TNF 23166614 2718109 Regulation IRAK1BP1 TLR7 18268037 1549361 Regulation IRAK1BP1 TLR7 PMC2271012 1605532 Regulation IRAK2 TLR7 19564352 1555296 Regulation IRAK2 TNF 12493069 658441 Regulation IRAK3 TLR7 21390243 1049731 Regulation IRAK3 TLR7 22928050 2681964 Regulation IRAK3 TLR7 22928050 2681990 Regulation IRAK3 TLR7 22928050 2682020 Regulation IRAK3 TNF 12493069 658438 Regulation IRAK4 TLR7 17485511 1545768 Regulation IRAK4 TLR7 17893200 1547179 Regulation IRAK4 TNF 12493069 658439 Regulation IRF1 TLR7 15851485 1535917 Regulation IRF1 TLR7 15851485 1535971 Regulation IRF1 TLR7 24568879 222821 Regulation IRF4 FOXO1 23835343 727933 Regulation IRF5 TLR7 19430534 2416275 Regulation IRF5 TLR7 19430534 2416276 Regulation IRF5 TLR7 21253574 3050452 Regulation IRF5 TLR7 21253574 3050475 Regulation IRF5 TLR7 25084355 2994349 Regulation IRF6 TP63 21918538 1630511 Regulation IRF7 OASL 24393529 222599 Regulation IRF7 OASL 24393529 222601 Regulation IRF7 OASL 24393529 222603 Regulation IRF7 TLR7 19430534 2416278 Regulation IRF7 TLR7 21197425 979829 Regulation IRF7 TLR7 21743479 1955572 Regulation IRF7 TLR7 21743479 1955606 Regulation IRF8 TLR7 24155889 2871090 Regulation IRS1 EPHB2 19953085 1903256 Regulation IRS1 EPHB2 19956598 2432175 Regulation IRS1 EPHB2 22875989 1806491 Regulation IRS1 FAS 24275630 1158363 Regulation IRS1 TNF 18443205 705841 Regulation IRS1 TNF 19808894 711290 Regulation IRS1 TNF 21386087 718363 Regulation IRS1 TNF 25352752 1917490 Regulation IRS1 WNT7A 22179044 1928148 Regulation IRS2 FOXO1 21933986 720642 Regulation IRS2 FOXO1 22384192 2607232 Regulation IRS4 ASB4 21955513 387317 Regulation IRS4 ASB4 21955513 387318 Regulation IRS4 ASB4 21955513 387319 Regulation IRS4 ASB4 21955513 387327 Regulation IRS4 IGF1 19534786 525655 Regulation IRS4 TRB 24886479 3124699 Regulation ISG15 TLR7 22558189 2624548 Regulation ISG15 TNF 25414636 939368 Regulation ISG20 TLR7 22558189 2624558 Regulation ISG20 TNF 25414636 939369 Regulation ISL1 CCND1 21829621 2542089 Regulation ISL1 CCND1 21829621 2542090 Regulation ITCH EPHB2 24708812 1843044 Regulation ITCH EPHB2 24708812 1843049 Regulation ITCH EPHB2 24708812 1843052 Regulation ITCH HRH1 18667087 1897067 Regulation ITGA9 MYLIP 24803669 2100787 Regulation ITGA9 RHO 22509805 3206651 Regulation ITGAL CA2 1346139 1297624 Regulation ITGAL CAPN1 20479866 2449892 Regulation ITGAL CAPN1 22046434 2567881 Regulation ITGAL CAPN10 20479866 2449893 Regulation ITGAL CAPN10 22046434 2567882 Regulation ITGAL CAPN11 20479866 2449894 Regulation ITGAL CAPN11 22046434 2567883 Regulation ITGAL CAPN12 20479866 2449891 Regulation ITGAL CAPN12 22046434 2567880 Regulation ITGAL CAPN13 20479866 2449902 Regulation ITGAL CAPN13 22046434 2567891 Regulation ITGAL CAPN14 20479866 2449903 Regulation ITGAL CAPN14 22046434 2567892 Regulation ITGAL CAPN15 20479866 2449890 Regulation ITGAL CAPN15 22046434 2567879 Regulation ITGAL CAPN2 20479866 2449895 Regulation ITGAL CAPN2 22046434 2567884 Regulation ITGAL CAPN3 20479866 2449896 Regulation ITGAL CAPN3 22046434 2567885 Regulation ITGAL CAPN5 20479866 2449897 Regulation ITGAL CAPN5 22046434 2567886 Regulation ITGAL CAPN6 20479866 2449898 Regulation ITGAL CAPN6 22046434 2567887 Regulation ITGAL CAPN7 20479866 2449899 Regulation ITGAL CAPN7 22046434 2567888 Regulation ITGAL CAPN8 20479866 2449900 Regulation ITGAL CAPN8 22046434 2567889 Regulation ITGAL CAPN9 20479866 2449901 Regulation ITGAL CAPN9 22046434 2567890 Regulation ITGAL CD226 14676297 1529995 Regulation ITGAL CD226 14676297 1529996 Regulation ITGAL CD226 14676297 1530010 Regulation ITGAL CD28 1569401 1534412 Regulation ITGAL CD47 24006483 1817989 Regulation ITGAL CD47 24006483 1817992 Regulation ITGAL CD47 24006483 1818015 Regulation ITGAL CD53 24832104 2970511 Regulation ITGAL CD53 24832104 2970527 Regulation ITGAL CTTN 21788407 1564380 Regulation ITGAL EDN1 18029384 90724 Regulation ITGAL ICAM1 3128630 1580272 Regulation ITGAL ICAM1 7520448 1436252 Regulation ITGAL ICAM2 7520448 1436253 Regulation ITGAL ICAM3 7520448 1436254 Regulation ITGAL ICAM3 7520448 1436258 Regulation ITGAL ICAM4 7520448 1436255 Regulation ITGAL ICAM5 7520448 1436256 Regulation ITGAL LCP2 22291096 1567035 Regulation ITGAL MAP2K3 21206905 2491135 Regulation ITGAL NAPA 11259095 418397 Regulation ITGAL NT5E 9015312 1459035 Regulation ITGAL PDLIM7 24068937 3064207 Regulation ITGAL PIK3CA 20174606 2291188 Regulation ITGAL PIK3R1 20174606 2291189 Regulation ITGAL PLAC8 23999103 786309 Regulation ITGAL PTPRC 7520448 1436257 Regulation ITGAL PTPRC 8018541 444522 Regulation ITGAL RAP2A 12707305 1292122 Regulation ITGAL RFX1 23510070 128081 Regulation ITGAL SELPLG 18045459 352097 Regulation ITGAL SKAP1 15939789 1536343 Regulation ITGAL SYK 18045459 352098 Regulation ITGAL TLN1 24945611 2981362 Regulation ITGAL VAV1 24368807 1413289 Regulation ITGAL ZAP70 24596147 753318 Regulation ITGAM ALOX5 18475524 1744201 Regulation ITGAM ITGB2 21103413 2483944 Regulation ITGAM SELL 23573259 2778016 Regulation ITGAX ITGB2 21103413 2483945 Regulation ITGB1 ID1 24062740 908913 Regulation ITGB2 ACD 20733035 1559646 Regulation ITGB2 CA2 7510713 1435247 Regulation ITGB2 CCL21 24945611 2981354 Regulation ITGB2 CCR7 10620605 1513832 Regulation ITGB2 CCR7 24195963 988973 Regulation ITGB2 CD14 10587349 1513471 Regulation ITGB2 CD226 14676297 1529997 Regulation ITGB2 CD226 14676297 1529998 Regulation ITGB2 CD28 24376655 2901728 Regulation ITGB2 CD47 24006483 1817994 Regulation ITGB2 CD47 24006483 1818008 Regulation ITGB2 CD47 24006483 1818012 Regulation ITGB2 CD99 18521343 3127576 Regulation ITGB2 CDC73 1315317 1297521 Regulation ITGB2 CDL1 1717478 1335490 Regulation ITGB2 CHEK2 23959798 1880524 Regulation ITGB2 CTLA4 24376655 2901729 Regulation ITGB2 CTR9 1315317 1297522 Regulation ITGB2 CXCL1 21970746 354726 Regulation ITGB2 CXCL12 23554986 2774177 Regulation ITGB2 DEFA1B 7686213 1591517 Regulation ITGB2 FERMT3 22701459 901713 Regulation ITGB2 ICAM1 21909384 2551705 Regulation ITGB2 ICAM1 7510713 1435248 Regulation ITGB2 IL3 18214796 1042548 Regulation ITGB2 IL8 1969919 1555845 Regulation ITGB2 IL8 1969919 1555851 Regulation ITGB2 ITGAL 7515097 1589177 Regulation ITGB2 ITGAM 25036109 2990568 Regulation ITGB2 JAK2 24368807 1413208 Regulation ITGB2 JAK3 24368807 1413209 Regulation ITGB2 LCP1 24438191 1871482 Regulation ITGB2 LEO1 1315317 1297525 Regulation ITGB2 MCOLN1 21909384 2551702 Regulation ITGB2 PAF1 1315317 1297523 Regulation ITGB2 PARP1 20090957 2437684 Regulation ITGB2 PLD1 22654882 901238 Regulation ITGB2 POT1 20733035 1559644 Regulation ITGB2 PTH 22144889 3054868 Regulation ITGB2 PTX3 18475549 1744291 Regulation ITGB2 PTX3 18475549 1744292 Regulation ITGB2 PTX3 18475551 1744304 Regulation ITGB2 PTX3 18475551 1744305 Regulation ITGB2 PTX4 18475549 1744289 Regulation ITGB2 PTX4 18475549 1744290 Regulation ITGB2 PTX4 18475551 1744302 Regulation ITGB2 PTX4 18475551 1744303 Regulation ITGB2 RAD50 20733035 1559647 Regulation ITGB2 RHOA 22654882 901237 Regulation ITGB2 SOD1 23959798 1880523 Regulation ITGB2 SOD1 23959798 1880536 Regulation ITGB2 SOD1 23959798 1880542 Regulation ITGB2 SOD2 23959798 1880543 Regulation ITGB2 SOD3 23959798 1880544 Regulation ITGB2 SRC 22110576 2572177 Regulation ITGB2 SRC 22110576 2572253 Regulation ITGB2 TERF1 20733035 1559641 Regulation ITGB2 TERF2 20733035 1559642 Regulation ITGB2 TERF2IP 20733035 1559645 Regulation ITGB2 TINF2 20733035 1559643 Regulation ITGB2 TLN1 22701459 901712 Regulation ITGB2 TLN1 22701459 901717 Regulation ITGB2 WDR61 1315317 1297524 Regulation ITIH4 TNF 21599974 1898300 Regulation ITIH4 TNF 21599974 1898302 Regulation ITM2B TNF 23987141 345027 Regulation ITSN1 EPHB2 20824214 2474044 Regulation ITSN2 EPHB2 20824214 2474047 Regulation IVD MMP28 21801383 1652102 Regulation JAG1 BRCA1 23863842 2091392 Regulation JAG1 BRCA1 23863842 2091393 Regulation JAG1 CA2 24239355 609204 Regulation JAG1 DKC1 22351600 778090 Regulation JAG1 DLL1 21124801 2484110 Regulation JAG1 EIF4E 25466251 609749 Regulation JAG1 EPHB2 25164432 1484770 Regulation JAG1 ERF 23630463 866828 Regulation JAG1 GDF2 24896812 2976224 Regulation JAG1 HIGD1A 23115560 968867 Regulation JAG1 HNRNPF 20479116 1558266 Regulation JAG1 HNRNPH1 20479116 1558267 Regulation JAG1 HSP90AA1 22351600 778091 Regulation JAG1 IGFALS 25609923 744636 Regulation JAG1 IGFALS 25609923 744637 Regulation JAG1 IGFALS 25609923 744776 Regulation JAG1 IL1A 23495140 780225 Regulation JAG1 KDM4A 24886710 475121 Regulation JAG1 LATS2 22027184 3160008 Regulation JAG1 MAMLD1 24391519 2355278 Regulation JAG1 MIR335 24885481 273349 Regulation JAG1 MYB 23115560 968868 Regulation JAG1 MYLIP 21857907 2544265 Regulation JAG1 MYLIP 21887253 2548194 Regulation JAG1 MYLIP 21887253 2548876 Regulation JAG1 MYLIP 21887253 2548877 Regulation JAG1 MYLIP 22363487 2599554 Regulation JAG1 MYLIP 22363487 2599568 Regulation JAG1 MYLIP 22363487 2599573 Regulation JAG1 MYLIP 23028429 2690541 Regulation JAG1 MYLIP 23768087 268940 Regulation JAG1 MYLIP 24694752 3141349 Regulation JAG1 MYLIP 25018733 965455 Regulation JAG1 NOTCH1 20953350 2174572 Regulation JAG1 NOTCH1 22390640 124914 Regulation JAG1 NOTCH1 22487493 3207597 Regulation JAG1 NOTCH1 24688641 657008 Regulation JAG1 NOTCH2 20953350 2174573 Regulation JAG1 NOTCH2 22390640 124915 Regulation JAG1 NOTCH2 22487493 3207598 Regulation JAG1 NOTCH2 24688641 657009 Regulation JAG1 NOTCH3 20953350 2174574 Regulation JAG1 NOTCH3 22487493 3207599 Regulation JAG1 NOTCH3 24688641 657010 Regulation JAG1 NOTCH4 20953350 2174575 Regulation JAG1 NOTCH4 22487493 3207600 Regulation JAG1 NOTCH4 24688641 657011 Regulation JAG1 PML 23455394 1720924 Regulation JAG1 PTBP1 20479116 1558268 Regulation JAG1 PTBP2 20479116 1558265 Regulation JAG1 PTGES3 22351600 778089 Regulation JAG1 RARA 23455394 1720925 Regulation JAG1 RPL10 22943452 828109 Regulation JAG1 RPL11 22943452 828110 Regulation JAG1 RPL12 22943452 828111 Regulation JAG1 RPL13 22943452 828112 Regulation JAG1 RPL14 22943452 828113 Regulation JAG1 RPL15 22943452 828114 Regulation JAG1 RPL17 22943452 828115 Regulation JAG1 RPL18 22943452 828116 Regulation JAG1 RPL19 22943452 828117 Regulation JAG1 RPL21 22943452 828118 Regulation JAG1 RPL22 22943452 828119 Regulation JAG1 RPL23 22943452 828120 Regulation JAG1 RPL24 22943452 828121 Regulation JAG1 RPL26 22943452 828122 Regulation JAG1 RPL27 22943452 828123 Regulation JAG1 RPL28 22943452 828124 Regulation JAG1 RPL29 22943452 828125 Regulation JAG1 RPL3 22943452 828126 Regulation JAG1 RPL30 22943452 828127 Regulation JAG1 RPL31 22943452 828128 Regulation JAG1 RPL32 22943452 828129 Regulation JAG1 RPL34 22943452 828130 Regulation JAG1 RPL35 22943452 828131 Regulation JAG1 RPL36 22943452 828142 Regulation JAG1 RPL37 22943452 828132 Regulation JAG1 RPL38 22943452 828133 Regulation JAG1 RPL39 22943452 828134 Regulation JAG1 RPL4 22943452 828135 Regulation JAG1 RPL41 22943452 828136 Regulation JAG1 RPL5 22943452 828137 Regulation JAG1 RPL6 22943452 828138 Regulation JAG1 RPL7 22943452 828139 Regulation JAG1 RPL8 22943452 828140 Regulation JAG1 RPL9 22943452 828141 Regulation JAG1 SERPINE1 23494120 83890 Regulation JAG1 SETD2 22225988 469621 Regulation JAG1 SNX17 25408867 608134 Regulation JAG1 SNX17 25408867 608183 Regulation JAG1 SOD1 25609923 744830 Regulation JAG1 SOD1 25609923 744854 Regulation JAG1 TCF12 20150991 1161088 Regulation JAG1 TCF15 20150991 1161089 Regulation JAG1 TCF19 20150991 1161090 Regulation JAG1 TCF20 20150991 1161091 Regulation JAG1 TCF21 20150991 1161092 Regulation JAG1 TCF23 20150991 1161096 Regulation JAG1 TCF24 20150991 1161098 Regulation JAG1 TCF25 20150991 1161097 Regulation JAG1 TCF3 20150991 1161093 Regulation JAG1 TCF4 20150991 1161094 Regulation JAG1 TCF7 20150991 1161095 Regulation JAG1 TCF7L2 21437251 2509045 Regulation JAG1 TERT 22351600 778088 Regulation JAG1 TNF 23531541 1103927 Regulation JAG1 TP53 24098521 2858049 Regulation JAG1 TP53 24098521 2858068 Regulation JAG1 TP53 24098521 2858072 Regulation JAG1 TP53 24098521 2858074 Regulation JAG1 TP53 24098521 2858078 Regulation JAG1 WNT1 20953350 2174565 Regulation JAG1 WNT1 20953350 2174576 Regulation JAG1 WNT1 20953350 2174583 Regulation JAG1 WNT11 20953350 2174566 Regulation JAG1 WNT11 20953350 2174577 Regulation JAG1 WNT11 20953350 2174584 Regulation JAG1 WNT16 20953350 2174571 Regulation JAG1 WNT16 20953350 2174582 Regulation JAG1 WNT16 20953350 2174589 Regulation JAG1 WNT2 20953350 2174567 Regulation JAG1 WNT2 20953350 2174578 Regulation JAG1 WNT2 20953350 2174585 Regulation JAG1 WNT3 20953350 2174568 Regulation JAG1 WNT3 20953350 2174579 Regulation JAG1 WNT3 20953350 2174586 Regulation JAG1 WNT4 20953350 2174569 Regulation JAG1 WNT4 20953350 2174580 Regulation JAG1 WNT4 20953350 2174587 Regulation JAG1 WNT6 20953350 2174570 Regulation JAG1 WNT6 20953350 2174581 Regulation JAG1 WNT6 20953350 2174588 Regulation JAK1 CEACAM6 24069556 1706902 Regulation JAK2 CCND1 24004818 1618329 Regulation JAK2 MAP2K6 21183952 1720064 Regulation JMJD6 RNASE1 24914048 2101788 Regulation JMJD6 RNASE7 24914048 2101796 Regulation JUN CTGF 22212430 14252 Regulation JUN DAPK1 23114086 625154 Regulation JUN EPHB2 10839298 417142 Regulation JUN EPHB2 19417730 7465 Regulation JUN EPHB2 21167049 403527 Regulation JUN EPHB2 22294553 777996 Regulation JUN EPHB2 23226069 2249758 Regulation JUN EPHB2 23646205 2788775 Regulation JUN EPHB2 23670595 1106840 Regulation JUN EPHB2 24116275 204272 Regulation JUN EPHB2 24223737 2876949 Regulation JUN EPHB2 24278338 2885780 Regulation JUN EPHB2 25077945 2993617 Regulation JUN EPHB2 25101306 1622668 Regulation JUN EPHB2 25121739 2997357 Regulation JUN FAS 23029562 2698820 Regulation JUN FAS 23760585 945438 Regulation JUN IL1B 22642771 1662992 Regulation JUN IL1B 22642771 1662993 Regulation JUN IRS4 19539371 1718774 Regulation JUN MAP2K6 22294553 778002 Regulation JUN MAP2K6 23060802 959377 Regulation JUN MAP2K6 24116275 204278 Regulation JUN MMP28 25099178 2995524 Regulation JUN MMP7 25099178 2995539 Regulation JUN PTGER2 25327961 216549 Regulation JUN TLR7 19668221 1952720 Regulation JUN TLR7 21390243 1049741 Regulation JUN TNF 10359574 1511813 Regulation JUN TNF 10359574 1511814 Regulation JUN TNF 11684708 1275858 Regulation JUN TNF 15043753 3095699 Regulation JUN TNF 16359550 3105887 Regulation JUN TNF 16359550 3105888 Regulation JUN TNF 16359550 3105953 Regulation JUN TNF 20418897 9900 Regulation JUN TNF 20507572 353447 Regulation JUN TNF 20936779 1964430 Regulation JUN TNF 21152033 2485837 Regulation JUN TNF 21915344 2553426 Regulation JUN TNF 22618772 722986 Regulation JUN TNF 23173923 381199 Regulation JUN TNF 23482819 89198 Regulation JUN TNF 23784308 606150 Regulation JUN TNF 24587316 2929406 Regulation JUN TNF 24587316 2929407 Regulation JUN TNF 25009774 3094540 Regulation JUN TNF 8691131 1598236 Regulation JUNB CCND1 21108789 1860318 Regulation JUP TSPAN1 14691142 1303149 Regulation KANK2 CABP4 24646911 1125017 Regulation KANK4 AKT1 18458160 1351913 Regulation KANK4 AKT1 18458160 1351983 Regulation KANK4 AKT1 18458160 1352045 Regulation KANK4 AKT2 18458160 1351914 Regulation KANK4 AKT2 18458160 1351984 Regulation KANK4 AKT2 18458160 1352046 Regulation KANK4 AKT3 18458160 1351915 Regulation KANK4 AKT3 18458160 1351985 Regulation KANK4 AKT3 18458160 1352047 Regulation KANK4 PIK3CA 18458160 1351916 Regulation KANK4 PIK3CA 18458160 1351986 Regulation KANK4 PIK3CA 18458160 1352048 Regulation KANK4 PIK3R1 18458160 1351917 Regulation KANK4 PIK3R1 18458160 1351987 Regulation KANK4 PIK3R1 18458160 1352049 Regulation KARS GRIK2 23431475 2003057 Regulation KAT2B TGM2 22944909 1890299 Regulation KAT2B TNF 19052667 162866 Regulation KCNE1 CALM3 23593319 2780646 Regulation KCNE1 MYLIP 24386485 2904025 Regulation KCNE1 PIP 22787448 951950 Regulation KCNE1 PIP 24681627 2946967 Regulation KCNH2 KCNE1 17895974 2378201 Regulation KCNH2 KCNE1 17895974 2378214 Regulation KCNH2 KCNE1 24478792 885748 Regulation KCNH4 EPHB2 17664338 1342596 Regulation KCNH4 EPHB2 20137095 375098 Regulation KCNH4 TNF 24386331 2903639 Regulation KCNH8 EPHB2 12204819 791200 Regulation KCNK3 IYD 24586202 2357087 Regulation KCNK3 ST8SIA2 24743596 1823357 Regulation KCNQ1 KCNE1 19340287 2411418 Regulation KCNQ1 KCNE1 19687231 1609441 Regulation KCNQ1 KCNE1 21576273 1682632 Regulation KCNQ1 KCNE1 21576273 1682633 Regulation KCNQ1 KCNE1 22529812 951568 Regulation KCNQ1 KCNE1 24478792 885755 Regulation KCNQ1 KCNE1 24827085 3141893 Regulation KDM5B GJB2 23579952 1105439 Regulation KDM5B GJB2 23579952 1105445 Regulation KDR ANGPT1 23575676 1935919 Regulation KDR RCAN1 20625401 2454995 Regulation KHDRBS1 CCND1 22132318 1669548 Regulation KHDRBS1 EPHB2 24287914 1121856 Regulation KHSRP TNF 21519548 85489 Regulation KHSRP TNF 22615562 3056751 Regulation KHSRP TNF 22615562 3056764 Regulation KIF11 KRT38 22164253 2579541 Regulation KIF11 RAB31 19653898 1834092 Regulation KIF12 KRT38 22164253 2579167 Regulation KIF12 RAB31 19653898 1834011 Regulation KIF14 KRT38 22164253 2578989 Regulation KIF14 RAB31 19653898 1833930 Regulation KIF15 KRT38 22164253 2578825 Regulation KIF15 RAB31 19653898 1833849 Regulation KIF17 KRT38 22164253 2578939 Regulation KIF17 RAB31 19653898 1833903 Regulation KIF19 KRT38 22164253 2579259 Regulation KIF19 RAB31 19653898 1834038 Regulation KIF1A RAB31 19653898 1834227 Regulation KIF22 KRT38 22164253 2579641 Regulation KIF22 RAB31 19653898 1834146 Regulation KIF23 KRT38 22164253 2579691 Regulation KIF23 RAB31 19653898 1834173 Regulation KIF24 KRT38 22164253 2579039 Regulation KIF24 RAB31 19653898 1833957 Regulation KIF25 KRT38 22164253 2579591 Regulation KIF25 RAB31 19653898 1834119 Regulation KIF27 KRT38 22164253 2578889 Regulation KIF27 RAB31 19653898 1833876 Regulation KIF6 KRT38 22164253 2579117 Regulation KIF6 RAB31 19653898 1833984 Regulation KIF7 KRT38 22164253 2579421 Regulation KIF7 RAB31 19653898 1834065 Regulation KIF9 KRT38 22164253 2578775 Regulation KIF9 RAB31 19653898 1833822 Regulation KITLG TNF 24908398 297186 Regulation KL EPHB2 24386260 2903397 Regulation KL FOXO1 20844314 27713 Regulation KL TNF 21593200 719222 Regulation KLF2 FOXO1 22563336 1709966 Regulation KLF2 SELL 20601952 1953904 Regulation KLF2 SELL 24843022 756828 Regulation KLF2 SELL 24843022 756829 Regulation KLF4 TNF 25473217 88434 Regulation KLF8 CCND1 23222713 2151181 Regulation KLF8 CCND1 23222713 2151185 Regulation KLF8 EPHB2 21887232 2548012 Regulation KLF9 EDN1 18406357 158094 Regulation KLF9 MAP2K3 23825110 1034242 Regulation KLF9 MAPK1 25317150 2006863 Regulation KLF9 MAPK10 25317150 2006864 Regulation KLF9 MAPK11 25317150 2006865 Regulation KLF9 MAPK12 25317150 2006866 Regulation KLF9 MAPK13 25317150 2006867 Regulation KLF9 MAPK14 25317150 2006868 Regulation KLF9 MAPK15 25317150 2006862 Regulation KLF9 MAPK3 25317150 2006869 Regulation KLF9 MAPK4 25317150 2006870 Regulation KLF9 MAPK6 25317150 2006871 Regulation KLF9 MAPK7 25317150 2006872 Regulation KLF9 MAPK8 25317150 2006873 Regulation KLF9 MAPK9 25317150 2006874 Regulation KLF9 MYLIP 24349493 2898354 Regulation KLF9 MYLIP PMC3757848 3086677 Regulation KLF9 NR2F1 24349493 2898340 Regulation KLF9 NR2F1 24349493 2898349 Regulation KLF9 NR2F1 24349493 2898355 Regulation KLK3 CLU 24156019 492150 Regulation KLK3 MAP2K6 20126616 2439326 Regulation KLK3 MAP2K6 20126616 2439347 Regulation KLK3 TLR7 22860075 2671455 Regulation KLRC1 TLR7 24130907 2867683 Regulation KRAS DGKI 25233099 3008242 Regulation KRAS DGKI 25233099 3008249 Regulation KRAS EPHB2 17449939 1634820 Regulation KRAS EPHB2 18597688 251137 Regulation KRAS EPHB2 18629230 1212691 Regulation KRAS EPHB2 25003010 3092923 Regulation KRAS FOXO1 20375467 27034 Regulation KRAS FOXO1 23306151 1100404 Regulation KRAS FOXO1 24265619 962927 Regulation KRAS LGALS7B 23530091 2182841 Regulation KRAS LIPG 17967061 3039967 Regulation KRAS MAP2K6 18629230 1212697 Regulation KRAS STK39 24849659 2972598 Regulation KRAS TNF 25526565 1136162 Regulation KRIT1 FOXO1 20668652 2457232 Regulation KRR1 TNF 19262463 764090 Regulation KRR1 TNF 19373245 546132 Regulation KRR1 TNF 21670490 2176164 Regulation KRR1 TNF 23104095 1958277 Regulation KRT1 TGM2 24278578 3180218 Regulation KRT1 TP63 20808887 2317847 Regulation KRT10 TGM2 24278578 3180219 Regulation KRT12 TGM2 24278578 3180220 Regulation KRT13 TGM2 24278578 3180221 Regulation KRT14 TGM2 24278578 3180222 Regulation KRT15 TGM2 24278578 3180223 Regulation KRT16 TGM2 24278578 3180224 Regulation KRT17 TGM2 24278578 3180225 Regulation KRT18 TGM2 24278578 3180226 Regulation KRT19 TGM2 24278578 3180227 Regulation KRT2 TGM2 24278578 3180229 Regulation KRT20 TGM2 24278578 3180201 Regulation KRT222 TGM2 24278578 3180206 Regulation KRT23 TGM2 24278578 3180228 Regulation KRT24 TGM2 24278578 3180199 Regulation KRT25 TGM2 24278578 3180213 Regulation KRT26 TGM2 24278578 3180214 Regulation KRT27 TGM2 24278578 3180215 Regulation KRT28 TGM2 24278578 3180216 Regulation KRT3 TGM2 24278578 3180230 Regulation KRT31 TGM2 24278578 3180236 Regulation KRT32 TGM2 24278578 3180237 Regulation KRT34 TGM2 24278578 3180238 Regulation KRT35 TGM2 24278578 3180239 Regulation KRT36 TGM2 24278578 3180240 Regulation KRT37 TGM2 24278578 3180241 Regulation KRT38 ADIPOQ 23096717 1631510 Regulation KRT38 ADIPOQ 23096717 1631610 Regulation KRT38 ADIPOQ 23096717 1631660 Regulation KRT38 DNAJB1 23650580 851842 Regulation KRT38 EGF 2447102 1415596 Regulation KRT38 EGF 2447102 1415747 Regulation KRT38 EGF 6169731 1429914 Regulation KRT38 FOXN1 14610062 1300531 Regulation KRT38 HOXC13 24714551 2950032 Regulation KRT38 KIF11 22164253 2580044 Regulation KRT38 KIF12 22164253 2580041 Regulation KRT38 KIF14 22164253 2580038 Regulation KRT38 KIF15 22164253 2580035 Regulation KRT38 KIF17 22164253 2580037 Regulation KRT38 KIF19 22164253 2580042 Regulation KRT38 KIF22 22164253 2580046 Regulation KRT38 KIF23 22164253 2580047 Regulation KRT38 KIF24 22164253 2580039 Regulation KRT38 KIF25 22164253 2580045 Regulation KRT38 KIF27 22164253 2580036 Regulation KRT38 KIF6 22164253 2580040 Regulation KRT38 KIF7 22164253 2580043 Regulation KRT38 KIF9 22164253 2580034 Regulation KRT38 KRT14 1702787 1334280 Regulation KRT38 MYLIP 24451143 1123395 Regulation KRT38 NR3C2 9864372 1473476 Regulation KRT38 PRL 24853682 1050162 Regulation KRT38 RNF19A 17535969 1340735 Regulation KRT38 TCF12 24965658 3143791 Regulation KRT38 TCF15 24965658 3143792 Regulation KRT38 TCF19 24965658 3143793 Regulation KRT38 TCF20 24965658 3143794 Regulation KRT38 TCF21 24965658 3143795 Regulation KRT38 TCF23 24965658 3143799 Regulation KRT38 TCF24 24965658 3143801 Regulation KRT38 TCF25 24965658 3143800 Regulation KRT38 TCF3 24965658 3143796 Regulation KRT38 TCF4 24965658 3143797 Regulation KRT38 TCF7 24965658 3143798 Regulation KRT38 TGM2 24278578 3180242 Regulation KRT38 UBXN4 22292069 2593528 Regulation KRT38 ZEB1 20181230 255400 Regulation KRT39 TGM2 24278578 3180217 Regulation KRT4 TGM2 24278578 3180231 Regulation KRT40 TGM2 24278578 3180204 Regulation KRT5 TGM2 24278578 3180232 Regulation KRT7 TGM2 24278578 3180233 Regulation KRT71 TGM2 24278578 3180208 Regulation KRT72 TGM2 24278578 3180212 Regulation KRT73 TGM2 24278578 3180209 Regulation KRT74 TGM2 24278578 3180210 Regulation KRT75 TGM2 24278578 3180203 Regulation KRT76 TGM2 24278578 3180202 Regulation KRT77 TGM2 24278578 3180200 Regulation KRT78 TGM2 24278578 3180207 Regulation KRT79 TGM2 24278578 3180211 Regulation KRT8 TGM2 24278578 3180234 Regulation KRT80 TGM2 24278578 3180205 Regulation KRT81 TGM2 24278578 3180243 Regulation KRT82 TGM2 24278578 3180244 Regulation KRT83 TGM2 24278578 3180245 Regulation KRT84 TGM2 24278578 3180246 Regulation KRT85 TGM2 24278578 3180247 Regulation KRT86 TGM2 24278578 3180248 Regulation KRT9 TGM2 24278578 3180235 Regulation KRTAP9-9 NES 9151683 1460090 Regulation KRTAP9-9 NES 9151683 1460324 Regulation KSR1 EPHB2 23431403 2755427 Regulation KSR1 EPHB2 24829611 1650655 Regulation KSR1 F2R 24829611 1650750 Regulation KSR1 MAP2K6 24829611 1650661 Regulation LAMA4 LAMA3 24971943 2985137 Regulation LAMA4 PIK3CA 19584916 1212751 Regulation LAMA4 PIK3R1 19584916 1212752 Regulation LAMA5 PLAT 9531563 1466749 Regulation LAMB1 EPHB2 22904067 2080416 Regulation LAMB1 EPHB2 22904067 2080430 Regulation LAMB2 PLAT 9531563 1466751 Regulation LAMB3 CDKN1A 23805223 2807884 Regulation LAMB3 IFI27 22754369 1096188 Regulation LAMB3 MYLIP 23159910 2181645 Regulation LAMB3 MYLIP 23159910 2181647 Regulation LAMB3 MYLIP 23483249 1141571 Regulation LAMB3 MYLIP 23773282 483531 Regulation LAMB3 MYLIP 24091622 441992 Regulation LAMB3 MYLIP 24091622 441996 Regulation LAMB3 MYLIP 24091622 442002 Regulation LAMB3 PIK3CA 18283320 430351 Regulation LAMB3 PIK3R1 18283320 430352 Regulation LAMB3 PLG 24212644 497884 Regulation LAMB3 SMAD4 18664273 251248 Regulation LAMB3 SMAD4 18664273 251249 Regulation LAMB3 SMAD4 18664273 251250 Regulation LAMB3 SMAD4 18664273 251260 Regulation LAMB3 SMAD4 18664273 251265 Regulation LAMB3 SMAD4 18664273 251267 Regulation LAMB3 SMAD4 20307265 1853818 Regulation LAMB3 ZEB1 24212644 497881 Regulation LAMC2 EPHB2 24990076 742258 Regulation LAMC2 TNF 24990076 742248 Regulation LAMC2 TNF 24990076 742249 Regulation LAMC3 PLAT 9531563 1466753 Regulation LAMP1 TNF 21519548 85490 Regulation LANCL1 TLR7 18584038 3072745 Regulation LANCL1 TLR7 18584038 3074267 Regulation LANCL1 TLR7 19430534 2416279 Regulation LAT PECAM1 20723025 1692081 Regulation LAT PECAM1 20723025 1692089 Regulation LBP CNR1 22073164 2569451 Regulation LBP INS 20699433 729546 Regulation LBP NGF 25069717 132866 Regulation LBP SPARC 21867537 1898403 Regulation LCK EPHB2 21152094 2486261 Regulation LCN2 CAPN8 20200223 1774885 Regulation LCN2 MAP2K6 18852336 729102 Regulation LCN2 MAP2K6 18852336 729113 Regulation LCN2 TNF 21403867 1748819 Regulation LCN2 TNF 21403867 1748820 Regulation LCN2 TNF 23238132 651914 Regulation LCT TNF 22039370 1038374 Regulation LCT TNF 24490170 186731 Regulation LDLR EPHB2 19283084 3043427 Regulation LDLR PCSK9 17328821 279527 Regulation LDLR PCSK9 18547436 1722725 Regulation LDLR PCSK9 19196236 146453 Regulation LDLR PCSK9 19196236 146454 Regulation LDLR PCSK9 20423497 2112633 Regulation LDLR PCSK9 20498851 2451196 Regulation LDLR PCSK9 21792295 742469 Regulation LDLR PCSK9 23115612 668234 Regulation LDLR PCSK9 23298392 2113731 Regulation LDLR PCSK9 23344002 1905709 Regulation LDLR PCSK9 23430252 1206582 Regulation LDLR PCSK9 23430252 1206583 Regulation LDLR PCSK9 23675525 2793515 Regulation LDLR PCSK9 23675525 2793521 Regulation LDLR PCSK9 23675525 2793530 Regulation LDLR PCSK9 24252756 179025 Regulation LDLR PCSK9 24278757 3150672 Regulation LDLR PCSK9 24278757 3150679 Regulation LDLR PCSK9 24278757 3150684 Regulation LDLR PCSK9 24278757 3150687 Regulation LDLR PCSK9 24278757 3150688 Regulation LDLR PCSK9 24834104 2114035 Regulation LDLR PCSK9 24901470 2976871 Regulation LDLR PCSK9 25042549 19267 Regulation LDLR PCSK9 25064003 1726965 Regulation LDLR PCSK9 25064003 1726994 Regulation LDLR PCSK9 25349780 854164 Regulation LDLR TMEM100 23922764 2826458 Regulation LDLR TMEM156 23922764 2826476 Regulation LDLR TMEM211 23922764 2826556 Regulation LDLR TMEM213 23922764 2826493 Regulation LDLR TNF 7577459 444041 Regulation LEF1 PDE5A 25429621 579500 Regulation LEO1 ARSA 18475637 1745107 Regulation LEO1 LPCAT1 25415055 177562 Regulation LEO1 TNF 3119758 1580161 Regulation LEO1 TNF 3119758 1580162 Regulation LEO1 TNF 3119758 1580182 Regulation LEP EPHB2 19066310 707396 Regulation LEP EPHB2 19246598 708146 Regulation LEP EPHB2 25352831 881317 Regulation LEP GLP1R 22249232 1140321 Regulation LEP MAP2K6 23056265 2700828 Regulation LEP PGC 24086538 2854569 Regulation LEP TNF 21646388 719427 Regulation LEP TNF 22947075 337396 Regulation LEP TNF 23818912 637886 Regulation LEP TNF 24757680 189530 Regulation LEP TNF 8996253 1599920 Regulation LGALS7B CEBPA 24789216 2960208 Regulation LGALS7B FEN1 20543986 2452525 Regulation LGALS7B HRAS 23530091 2182839 Regulation LGALS7B RPGR 21289092 1786171 Regulation LGALS7B TP53 23530091 2182823 Regulation LGALS7B TP53 23530091 2182838 Regulation LGALS7B TP53 23530091 2182883 Regulation LGALS7B TP53 23985992 2184708 Regulation LGALS7B TP53 23985992 2184709 Regulation LGALS7B TP53 25277199 2203319 Regulation LGALS9 TLR7 23967307 2835844 Regulation LGMN CST6 23088560 266736 Regulation LHX2 PLAU 23864708 1816979 Regulation LHX2 PLAU 23864708 1816984 Regulation LHX2 PLAU 23864708 1816988 Regulation LHX2 PLAU 23864708 1816989 Regulation LHX2 PLAU 23864708 1816993 Regulation LHX2 PLAU 23864708 1816999 Regulation LHX2 PLAU 23864708 1817007 Regulation LHX2 PLAU 23864708 1817029 Regulation LIF EDN2 23372671 2745724 Regulation LIF RCAN1 19348862 158363 Regulation LIF STK39 9298977 1463151 Regulation LIF TNF 24008729 565520 Regulation LIF TNF 24008729 565521 Regulation LILRB1 EPHB2 23667323 2283046 Regulation LILRB2 TLR7 19860908 353178 Regulation LILRB4 TLR7 19860908 353188 Regulation LIMS1 NES 21390327 2506433 Regulation LIN37 AXIN2 21814488 2276980 Regulation LIN37 TNF 11581316 1521093 Regulation LIN52 AXIN2 21814488 2276972 Regulation LIN52 TNF 11581316 1521090 Regulation LIN54 AXIN2 21814488 2276974 Regulation LIN54 TNF 11581316 1521091 Regulation LIN9 AXIN2 21814488 2276978 Regulation LIN9 TNF 11581316 1521092 Regulation LINC00284 E2F4 21436991 1220646 Regulation LINC00284 RBL2 21436991 1220647 Regulation LINC00284 SUN1 24667841 2944385 Regulation LINC00284 SUN2 24667841 2944383 Regulation LINC00284 SUN3 24667841 2944386 Regulation LINC00284 SUN5 24667841 2944384 Regulation LINC00341 E2F4 21436991 1220566 Regulation LINC00341 RBL2 21436991 1220567 Regulation LINC00341 SUN1 24667841 2944225 Regulation LINC00341 SUN2 24667841 2944223 Regulation LINC00341 SUN3 24667841 2944226 Regulation LINC00341 SUN5 24667841 2944224 Regulation LIPA FOXO1 24136225 568093 Regulation LIPE G0S2 23499576 3204079 Regulation LIPE TNF 24475180 2915170 Regulation LIPG HRAS 17967061 3039968 Regulation LIPG IL6 19502419 708768 Regulation LIPG KRAS 17967061 3039969 Regulation LIPG LPO 23991116 2840960 Regulation LIPG MSTN 20161803 2440918 Regulation LIPG NRAS 17967061 3039970 Regulation LIPG PTN 24015201 2842305 Regulation LMO4 MAP2K6 19648968 2126248 Regulation LMX1A MSX1 21829537 2541639 Regulation LOR EPHB2 17449939 1634813 Regulation LOX CAPN8 25309925 201287 Regulation LOX TNF 24971753 2985067 Regulation LOX TNF 24971753 2985068 Regulation LPA ANGPT1 19297368 513371 Regulation LPA PCSK9 21232153 1723406 Regulation LPA PCSK9 23329883 1084344 Regulation LPA PCSK9 24278703 3150242 Regulation LPA PCSK9 24278757 3150686 Regulation LPA PCSK9 25600226 143173 Regulation LPA SLC6A2 21284875 258624 Regulation LPA SLC6A2 21284875 258627 Regulation LPA TNF 7577459 444042 Regulation LPAR2 EPHB2 21686182 1091074 Regulation LPAR3 EPHB2 21686182 1091071 Regulation LPCAT1 CA2 22676268 229988 Regulation LPCAT1 CA2 22676268 229990 Regulation LPCAT1 CA2 22676268 229993 Regulation LPCAT1 CREB1 22096492 2571600 Regulation LPCAT1 NOTCH1 22096492 2571601 Regulation LPCAT1 PLG 21364954 2504552 Regulation LPIN1 PGC 17612398 300677 Regulation LPIN1 PGC 19753306 2426498 Regulation LPIN1 PGC 21857965 2544442 Regulation LPIN1 PGC 23236470 2726512 Regulation LPL FOXO1 23443131 1102641 Regulation LPL ITGB2 7528765 1589730 Regulation LPL TNF 17162363 630557 Regulation LPL TNF 24790463 629891 Regulation LPL TNF 3385359 1581146 Regulation LPL TNF 3390373 443340 Regulation LPL TNF 7577459 444038 Regulation LPL TNF 9667678 447382 Regulation LRP1 EPHB2 12499359 1290496 Regulation LRP1 PCSK9 23675525 2793522 Regulation LRP1 PCSK9 23675525 2793531 Regulation LRP1 PCSK9 23675525 2793532 Regulation LRP1 PCSK9 25340851 3018948 Regulation LRP1 PLAT 21576385 1563912 Regulation LRP10 PLAT 21576385 1563909 Regulation LRP11 PLAT 21576385 1563910 Regulation LRP12 PLAT 21576385 1563911 Regulation LRP2 PLAT 21576385 1563913 Regulation LRP3 PLAT 21576385 1563914 Regulation LRP4 PLAT 21576385 1563915 Regulation LRP5 EPHB2 20011526 2433444 Regulation LRP5 PLAT 21576385 1563916 Regulation LRP6 PLAT 21576385 1563917 Regulation LRP8 PLAT 21576385 1563918 Regulation LRRC7 RINL 22291991 2591597 Regulation LRRK2 RGS2 25071441 932193 Regulation LRRN2 HOXB1 19602272 1994778 Regulation LRRN2 HOXB1 19602272 1994779 Regulation LRRN2 HOXB1 19602272 1994780 Regulation LRRN2 HOXB1 19602272 1994784 Regulation LRRN2 HOXB1 19602272 1994791 Regulation LRRN2 HOXB1 19602272 1994792 Regulation LRRN2 HOXB1 19602272 1994793 Regulation LRRN2 HOXB1 19602272 1994802 Regulation LRRN2 SHH 19602272 1994776 Regulation LRRN2 SHH 19602272 1994777 Regulation LRRN2 SHH 19602272 1994789 Regulation LRRN2 SHH 19602272 1994790 Regulation LRRN2 SHH 19602272 1994801 Regulation LSS ETV7 24357328 740822 Regulation LSS ETV7 24357328 740824 Regulation LTA CD14 24349012 2896577 Regulation LTA CD14 24349012 2896587 Regulation LTA CD14 24826382 190667 Regulation LTB ARSA 18475455 1743813 Regulation LTB MAP2K6 24634497 1624490 Regulation LTB TLR7 24634497 1624615 Regulation LTBP1 SERPINA5 23148642 339572 Regulation LTBP1 TGM2 9060478 1459495 Regulation LTBP1 TGM2 9060478 1459502 Regulation LTF EPHB2 15932641 382979 Regulation LY6D IL7 24023617 2843104 Regulation LY96 CD14 14517279 1529122 Regulation LYRM1 TNF 22110480 832218 Regulation LYZ TNF 18475501 1744097 Regulation MAD2L1 STK39 24025726 364114 Regulation MADCAM1 TNF 12625840 312749 Regulation MADCAM1 TNF 12625840 312754 Regulation MADCAM1 TNF 16259632 1624796 Regulation MADCAM1 TNF 16259632 1624802 Regulation MADCAM1 TNF 16259632 1624803 Regulation MADCAM1 TNF 24562309 1959949 Regulation MADD RAB31 19653898 1834200 Regulation MAGEE1 FAS 7595193 1590722 Regulation MALT1 EPHB2 19305426 2124966 Regulation MAMSTR TMEM100 22570537 489688 Regulation MAMSTR TMEM156 22570537 489706 Regulation MAMSTR TMEM211 22570537 489786 Regulation MAMSTR TMEM213 22570537 489723 Regulation MAOA ARNTL 25395965 3085982 Regulation MAOA CA2 17868476 384299 Regulation MAOA CA2 17868476 384300 Regulation MAOA CLOCK 25395965 3085979 Regulation MAOA COMT 24966828 898435 Regulation MAOA GGA1 23170116 842669 Regulation MAOA GGA1 23170116 842675 Regulation MAOA GGA1 23170116 842681 Regulation MAOA GGA2 23170116 842667 Regulation MAOA GGA2 23170116 842673 Regulation MAOA GGA2 23170116 842679 Regulation MAOA GGA3 23170116 842668 Regulation MAOA GGA3 23170116 842674 Regulation MAOA GGA3 23170116 842680 Regulation MAOA IL6 22906985 1718405 Regulation MAOA IL6 22906985 1718406 Regulation MAOA IL6 22906985 1718407 Regulation MAOA IL6 22906985 1718413 Regulation MAOA SRY 21695109 2276414 Regulation MAOA TCF12 25395965 3085970 Regulation MAOA TCF15 25395965 3085971 Regulation MAOA TCF19 25395965 3085972 Regulation MAOA TCF20 25395965 3085973 Regulation MAOA TCF21 25395965 3085974 Regulation MAOA TCF23 25395965 3085978 Regulation MAOA TCF24 25395965 3085981 Regulation MAOA TCF25 25395965 3085980 Regulation MAOA TCF3 25395965 3085975 Regulation MAOA TCF4 25395965 3085976 Regulation MAOA TCF7 25395965 3085977 Regulation MAOA TMBIM6 24292328 3138913 Regulation MAOA TMBIM6 24292328 3138920 Regulation MAOA TMBIM6 24292328 3138921 Regulation MAOB PGC 22246294 1033619 Regulation MAP1LC3A CLU 25503391 1947698 Regulation MAP1LC3A CLU 25503391 1947699 Regulation MAP1LC3A F3 24853422 576232 Regulation MAP1LC3A FAS 23585825 2778691 Regulation MAP2 EPHB2 17984326 1346314 Regulation MAP2 EPHB2 17984326 1346321 Regulation MAP2K1 CCND1 22833568 1806130 Regulation MAP2K1 CCND1 22833568 1806131 Regulation MAP2K1 CCND1 22833568 1806147 Regulation MAP2K1 EPHB2 14997206 424363 Regulation MAP2K1 EPHB2 24023871 2843882 Regulation MAP2K1 JAG1 21738743 2533610 Regulation MAP2K1 MAP2K6 19043603 3074792 Regulation MAP2K1 TLR7 20832340 1040222 Regulation MAP2K1 TLR7 20832340 1040244 Regulation MAP2K1 TLR7 22577336 3128565 Regulation MAP2K1 TNF 19808894 711292 Regulation MAP2K1 TNF 19808894 711293 Regulation MAP2K1 TNF 19808894 711294 Regulation MAP2K1 TNF 19808894 711440 Regulation MAP2K2 CCND1 22833568 1806132 Regulation MAP2K2 CCND1 22833568 1806133 Regulation MAP2K2 CCND1 22833568 1806148 Regulation MAP2K2 EPHB2 24023871 2843883 Regulation MAP2K2 JAG1 21738743 2533612 Regulation MAP2K2 TLR7 20832340 1040245 Regulation MAP2K2 TLR7 22577336 3128576 Regulation MAP2K2 TNF 19808894 711301 Regulation MAP2K2 TNF 19808894 711302 Regulation MAP2K2 TNF 19808894 711303 Regulation MAP2K2 TNF 19808894 711442 Regulation MAP2K3 CCND1 22833568 1806134 Regulation MAP2K3 CCND1 22833568 1806135 Regulation MAP2K3 CCND1 22833568 1806149 Regulation MAP2K3 EPHB2 24023871 2843884 Regulation MAP2K3 JAG1 21738743 2533614 Regulation MAP2K3 TLR7 20832340 1040246 Regulation MAP2K3 TLR7 22577336 3128587 Regulation MAP2K3 TNF 19808894 711310 Regulation MAP2K3 TNF 19808894 711311 Regulation MAP2K3 TNF 19808894 711312 Regulation MAP2K3 TNF 19808894 711444 Regulation MAP2K4 CCND1 22833568 1806136 Regulation MAP2K4 CCND1 22833568 1806137 Regulation MAP2K4 CCND1 22833568 1806150 Regulation MAP2K4 EPHB2 24023871 2843885 Regulation MAP2K4 JAG1 21738743 2533616 Regulation MAP2K4 TLR7 20832340 1040247 Regulation MAP2K4 TLR7 22577336 3128598 Regulation MAP2K4 TNF 19808894 711319 Regulation MAP2K4 TNF 19808894 711320 Regulation MAP2K4 TNF 19808894 711321 Regulation MAP2K4 TNF 19808894 711446 Regulation MAP2K5 CCND1 22833568 1806138 Regulation MAP2K5 CCND1 22833568 1806139 Regulation MAP2K5 CCND1 22833568 1806151 Regulation MAP2K5 EPHB2 24023871 2843886 Regulation MAP2K5 JAG1 21738743 2533618 Regulation MAP2K5 TLR7 20832340 1040248 Regulation MAP2K5 TLR7 22577336 3128609 Regulation MAP2K5 TNF 19808894 711328 Regulation MAP2K5 TNF 19808894 711329 Regulation MAP2K5 TNF 19808894 711330 Regulation MAP2K5 TNF 19808894 711448 Regulation MAP2K6 ABL1 19568437 2420821 Regulation MAP2K6 AKT1 22348085 2596815 Regulation MAP2K6 AKT2 22348085 2596816 Regulation MAP2K6 AKT3 22348085 2596817 Regulation MAP2K6 ATF3 22053207 2568032 Regulation MAP2K6 ATR 23640330 2087583 Regulation MAP2K6 BRAF 16846534 460002 Regulation MAP2K6 BRAF 23208503 2150258 Regulation MAP2K6 BRAF 23208503 2150281 Regulation MAP2K6 CASP1 22649423 875766 Regulation MAP2K6 CASP10 22649423 875767 Regulation MAP2K6 CASP12 22649423 875777 Regulation MAP2K6 CASP14 22649423 875768 Regulation MAP2K6 CASP16 22649423 875778 Regulation MAP2K6 CASP2 22649423 875769 Regulation MAP2K6 CASP3 22649423 875770 Regulation MAP2K6 CASP4 22649423 875771 Regulation MAP2K6 CASP5 22649423 875772 Regulation MAP2K6 CASP6 22649423 875773 Regulation MAP2K6 CASP7 22649423 875774 Regulation MAP2K6 CASP8 22649423 875775 Regulation MAP2K6 CASP9 22649423 875776 Regulation MAP2K6 CASR 23439762 1714774 Regulation MAP2K6 CCNA2 25187756 484838 Regulation MAP2K6 CCNA2 25187756 484857 Regulation MAP2K6 CCND1 22833568 1806140 Regulation MAP2K6 CCND1 22833568 1806141 Regulation MAP2K6 CCND1 22833568 1806152 Regulation MAP2K6 CDH1 22543706 14723 Regulation MAP2K6 CDKN1A 23006971 2181169 Regulation MAP2K6 CRK 23552557 2156010 Regulation MAP2K6 CROT 21107320 1986755 Regulation MAP2K6 CSF1 22028782 2564147 Regulation MAP2K6 CSF1 22028782 2564148 Regulation MAP2K6 CSF1 22028782 2564202 Regulation MAP2K6 CSF1 22028782 2564220 Regulation MAP2K6 CSF1 22028782 2564239 Regulation MAP2K6 CSF1 22028782 2564284 Regulation MAP2K6 CXCL12 23840250 820737 Regulation MAP2K6 CXCR4 23840250 820738 Regulation MAP2K6 CYP2E1 22028977 1078819 Regulation MAP2K6 DLL1 21738743 2533619 Regulation MAP2K6 DUSP6 19897477 1167274 Regulation MAP2K6 DUSP6 19897477 1167291 Regulation MAP2K6 EGF 21666717 2140190 Regulation MAP2K6 EGF 23105109 1205459 Regulation MAP2K6 EGFR 19517027 671877 Regulation MAP2K6 EGFR 22294553 777901 Regulation MAP2K6 EGFR 22294553 777902 Regulation MAP2K6 EPHB2 24023871 2843887 Regulation MAP2K6 FGF2 24880876 1964778 Regulation MAP2K6 HGF 23267331 960616 Regulation MAP2K6 HGF 24840640 1087374 Regulation MAP2K6 HRAS 18629230 1212714 Regulation MAP2K6 HRAS 19319189 2408592 Regulation MAP2K6 HRAS 21831290 1505446 Regulation MAP2K6 HRAS 23076254 604990 Regulation MAP2K6 IGKV6D-21 23840250 820739 Regulation MAP2K6 IL17A 16504032 392055 Regulation MAP2K6 IL1A 19808894 711340 Regulation MAP2K6 IL1A 19808894 711341 Regulation MAP2K6 IL1A 19808894 711342 Regulation MAP2K6 IL1A 19808894 711451 Regulation MAP2K6 INS 19808894 711343 Regulation MAP2K6 INS 19808894 711344 Regulation MAP2K6 INTS6 17895999 2378802 Regulation MAP2K6 JAG1 21738743 2533620 Regulation MAP2K6 JAK2 21183952 1720073 Regulation MAP2K6 JUN 23060802 959384 Regulation MAP2K6 KDR 21693010 468371 Regulation MAP2K6 KIF1B 20802223 2253149 Regulation MAP2K6 KRAS 18629230 1212715 Regulation MAP2K6 KRAS 21831290 1505447 Regulation MAP2K6 KRAS 23076254 604991 Regulation MAP2K6 KSR1 23105109 1205433 Regulation MAP2K6 LEP 24371782 1718807 Regulation MAP2K6 LYN 23826126 2810343 Regulation MAP2K6 LYN 23826126 2810344 Regulation MAP2K6 MAP2K1 24759913 2957840 Regulation MAP2K6 MAP3K13 23552557 2156011 Regulation MAP2K6 MAP3K13 23552557 2156012 Regulation MAP2K6 MAP3K5 22028977 1078805 Regulation MAP2K6 MAP3K8 19808894 711345 Regulation MAP2K6 MAPK1 23453810 1878039 Regulation MAP2K6 MAPK1 23704993 2797346 Regulation MAP2K6 MAPK10 23704993 2797347 Regulation MAP2K6 MAPK11 23704993 2797348 Regulation MAP2K6 MAPK12 23704993 2797349 Regulation MAP2K6 MAPK13 23704993 2797350 Regulation MAP2K6 MAPK14 23704993 2797351 Regulation MAP2K6 MAPK15 23704993 2797345 Regulation MAP2K6 MAPK3 23453810 1878040 Regulation MAP2K6 MAPK3 23704993 2797352 Regulation MAP2K6 MAPK3 23840250 820740 Regulation MAP2K6 MAPK3 24062636 938316 Regulation MAP2K6 MAPK4 23704993 2797353 Regulation MAP2K6 MAPK6 23704993 2797354 Regulation MAP2K6 MAPK7 23704993 2797355 Regulation MAP2K6 MAPK8 23704993 2797356 Regulation MAP2K6 MAPK9 23704993 2797357 Regulation MAP2K6 MSC 16168115 459095 Regulation MAP2K6 MSC 16168115 459096 Regulation MAP2K6 MTOR 23437362 2756583 Regulation MAP2K6 MXD1 16880791 427906 Regulation MAP2K6 NGF 20376360 2445435 Regulation MAP2K6 NOS1 19343212 3043678 Regulation MAP2K6 NPPA 20802223 2253166 Regulation MAP2K6 NPPA 20802223 2253167 Regulation MAP2K6 NPY6R 22182854 1720473 Regulation MAP2K6 NRAS 18629230 1212716 Regulation MAP2K6 NRAS 21831290 1505448 Regulation MAP2K6 NRAS 22475322 264507 Regulation MAP2K6 NRAS 23076254 604992 Regulation MAP2K6 PARK2 25535478 1615746 Regulation MAP2K6 PARK7 25535478 1615745 Regulation MAP2K6 PDGFRB 22213560 3171756 Regulation MAP2K6 PEBP1 22860010 2670772 Regulation MAP2K6 PI3 15067018 1307720 Regulation MAP2K6 PI3 15149544 241454 Regulation MAP2K6 PI3 18091994 2381416 Regulation MAP2K6 PIM1 21860423 2142203 Regulation MAP2K6 PINK1 25535478 1615744 Regulation MAP2K6 PKN1 21494665 2513490 Regulation MAP2K6 POLDIP2 22219646 1913736 Regulation MAP2K6 PPP2CA 19897477 1167275 Regulation MAP2K6 PPP2CA 23640330 2087584 Regulation MAP2K6 PPP2R1A 19897477 1167276 Regulation MAP2K6 PPP2R1A 23640330 2087585 Regulation MAP2K6 PPP2R2B 19897477 1167277 Regulation MAP2K6 PPP2R2B 23640330 2087586 Regulation MAP2K6 PRKACB 18955270 811097 Regulation MAP2K6 PRKACG 18955270 811098 Regulation MAP2K6 PRKAR1A 18955270 811099 Regulation MAP2K6 PRKAR1B 18955270 811100 Regulation MAP2K6 PRKAR2A 18955270 811101 Regulation MAP2K6 PRKAR2B 18955270 811102 Regulation MAP2K6 PTEN 9832564 1472260 Regulation MAP2K6 PTPN13 19734941 2126787 Regulation MAP2K6 RAC1 23006971 2181170 Regulation MAP2K6 RAC2 23006971 2181171 Regulation MAP2K6 RAC3 23006971 2181172 Regulation MAP2K6 RAF1 20624904 1377622 Regulation MAP2K6 RAF1 22860010 2670773 Regulation MAP2K6 RAF1 22984397 2688276 Regulation MAP2K6 RB1 23640330 2087587 Regulation MAP2K6 RIT1 24469055 2154667 Regulation MAP2K6 RIT1 24469055 2154687 Regulation MAP2K6 RNF19A 23552557 2156154 Regulation MAP2K6 SHC1 20624904 1377632 Regulation MAP2K6 SIX1 22765220 471725 Regulation MAP2K6 SIX1 22765220 471743 Regulation MAP2K6 SMAD7 24090133 537613 Regulation MAP2K6 SMURF2 23250956 1651801 Regulation MAP2K6 SP1 23640330 2087582 Regulation MAP2K6 SPRY1 24970815 2194228 Regulation MAP2K6 SPRY2 24970815 2194229 Regulation MAP2K6 SPRY3 24970815 2194230 Regulation MAP2K6 SPRY4 24970815 2194231 Regulation MAP2K6 SRC 21785723 1686384 Regulation MAP2K6 THEMIS 19597499 1952620 Regulation MAP2K6 TLR1 22577336 3128614 Regulation MAP2K6 TLR10 22577336 3128623 Regulation MAP2K6 TLR2 22577336 3128615 Regulation MAP2K6 TLR3 22577336 3128616 Regulation MAP2K6 TLR4 22577336 3128617 Regulation MAP2K6 TLR5 22577336 3128618 Regulation MAP2K6 TLR6 22577336 3128624 Regulation MAP2K6 TLR7 20832340 1040249 Regulation MAP2K6 TLR7 22577336 3128620 Regulation MAP2K6 TLR8 22577336 3128621 Regulation MAP2K6 TLR9 22577336 3128622 Regulation MAP2K6 TNF 19808894 711337 Regulation MAP2K6 TNF 19808894 711338 Regulation MAP2K6 TNF 19808894 711339 Regulation MAP2K6 TNF 19808894 711450 Regulation MAP2K6 TNFSF11 22577336 3128619 Regulation MAP2K6 TYR 24129178 1113295 Regulation MAP2K6 USP15 23105109 1205432 Regulation MAP2K6 YWHAB 23208503 2150259 Regulation MAP2K6 YWHAB 23208503 2150282 Regulation MAP2K7 CCND1 22833568 1806142 Regulation MAP2K7 CCND1 22833568 1806143 Regulation MAP2K7 CCND1 22833568 1806153 Regulation MAP2K7 EPHB2 24023871 2843888 Regulation MAP2K7 JAG1 21738743 2533622 Regulation MAP2K7 TLR7 20832340 1040250 Regulation MAP2K7 TLR7 22577336 3128631 Regulation MAP2K7 TNF 19808894 711346 Regulation MAP2K7 TNF 19808894 711347 Regulation MAP2K7 TNF 19808894 711348 Regulation MAP2K7 TNF 19808894 711452 Regulation MAP2K7 TNF 22348197 497104 Regulation MAP3K1 PLAU 16887003 460077 Regulation MAP3K11 TNF 19918265 609850 Regulation MAP3K11 TNF 19918265 609876 Regulation MAP3K5 CTGF 23227240 2725723 Regulation MAP3K5 FAS 22719792 814726 Regulation MAP3K5 TFPI2 22654913 1068289 Regulation MAP3K5 TNF 22719792 814725 Regulation MAP3K7 TLR7 19234607 2406044 Regulation MAP3K7 TLR7 24498425 2919887 Regulation MAP3K7 TNF 23844119 2819474 Regulation MAP3K7 TNF 24535827 1416516 Regulation MAP3K7 TNF 24535827 1416607 Regulation MAP3K7 TNFSF10 20062539 2436820 Regulation MAP3K8 EPHB2 15575964 1844345 Regulation MAP3K8 NEDD9 23557442 151390 Regulation MAP3K8 TNF 19808894 711367 Regulation MAP3K8 TNF 19808894 711454 Regulation MAP4K4 TNF 24244164 3064993 Regulation MAPK1 ALOX5 25025775 2989423 Regulation MAPK1 ANGPT1 25329960 3017048 Regulation MAPK1 CD14 21387014 2506195 Regulation MAPK1 CHI3L1 23755018 961399 Regulation MAPK1 EPHB2 18648505 2393340 Regulation MAPK1 EPHB2 20100173 212598 Regulation MAPK1 EPHB2 21411626 1788951 Regulation MAPK1 EPHB2 21559189 1052557 Regulation MAPK1 EPHB2 21811439 933302 Regulation MAPK1 EPHB2 21989417 1041860 Regulation MAPK1 EPHB2 22182854 1720475 Regulation MAPK1 EPHB2 24005988 658068 Regulation MAPK1 FAS 21975294 552744 Regulation MAPK1 FAS 21975294 552745 Regulation MAPK1 FAS 23029562 2698802 Regulation MAPK1 FOXO1 20375467 27038 Regulation MAPK1 HBEGF 22984591 2689352 Regulation MAPK1 ITGB2 21314908 3209840 Regulation MAPK1 MAP2K6 14981092 1306537 Regulation MAPK1 MAP2K6 15184504 1532833 Regulation MAPK1 MAP2K6 15353558 1533395 Regulation MAPK1 MAP2K6 16103225 1323241 Regulation MAPK1 MAP2K6 17442097 108215 Regulation MAPK1 MAP2K6 19043603 3074799 Regulation MAPK1 MAP2K6 20955562 120585 Regulation MAPK1 MAP2K6 21699731 1862609 Regulation MAPK1 MAP2K6 22164285 2580320 Regulation MAPK1 MAP2K6 22408427 1095113 Regulation MAPK1 MAP2K6 22415879 722056 Regulation MAPK1 MAP2K6 22545230 3163630 Regulation MAPK1 MAP2K6 23049945 2699920 Regulation MAPK1 MAP2K6 23097702 623102 Regulation MAPK1 MAP2K6 23115639 2711473 Regulation MAPK1 MAP2K6 23704993 2797376 Regulation MAPK1 MAP2K6 24371149 2186345 Regulation MAPK1 MIP 17233909 351823 Regulation MAPK1 MMP28 15841081 425576 Regulation MAPK1 MMP7 15841081 425591 Regulation MAPK1 MUC16 23694968 3135845 Regulation MAPK1 NES 23928293 3169647 Regulation MAPK1 NGFR 22880054 2673901 Regulation MAPK1 PGC 22829833 1068749 Regulation MAPK1 PTGER2 25327961 216550 Regulation MAPK1 RARB 18445634 2034356 Regulation MAPK1 RCAN1 19124655 1553373 Regulation MAPK1 RGS2 18067675 461888 Regulation MAPK1 RGS2 24743392 2955373 Regulation MAPK1 S100B 22276098 2589844 Regulation MAPK1 SARM1 21850204 1057553 Regulation MAPK1 SLC6A2 18509476 2389909 Regulation MAPK1 SPHK1 20498849 2451145 Regulation MAPK1 SPHK1 20498849 2451179 Regulation MAPK1 SPHK1 20634980 2455778 Regulation MAPK1 SPHK1 20634980 2455811 Regulation MAPK1 STK39 10587355 1513524 Regulation MAPK1 TLR7 19043549 3042617 Regulation MAPK1 TLR7 20832340 1040251 Regulation MAPK1 TLR7 22829768 3058054 Regulation MAPK1 TLR7 22829768 3058481 Regulation MAPK1 TLR7 23527104 2769510 Regulation MAPK1 TNF 15175101 523672 Regulation MAPK1 TNF 15642133 102199 Regulation MAPK1 TNF 16207331 104251 Regulation MAPK1 TNF 16542479 105587 Regulation MAPK1 TNF 21572963 2520275 Regulation MAPK1 TNF 22973314 1068999 Regulation MAPK1 TNF 23326019 1751343 Regulation MAPK1 TNF 24039713 2844648 Regulation MAPK1 TNF 24304472 1482110 Regulation MAPK1 TNF 24614867 2933207 Regulation MAPK10 ALOX5 25025775 2989424 Regulation MAPK10 ANGPT1 25329960 3017050 Regulation MAPK10 CD14 21387014 2506196 Regulation MAPK10 CHI3L1 23755018 961400 Regulation MAPK10 EPHB2 18648505 2393341 Regulation MAPK10 EPHB2 20100173 212599 Regulation MAPK10 EPHB2 21411626 1788952 Regulation MAPK10 EPHB2 22182854 1720477 Regulation MAPK10 EPHB2 24005988 658069 Regulation MAPK10 FAS 21975294 552746 Regulation MAPK10 FAS 21975294 552747 Regulation MAPK10 FAS 23029562 2698803 Regulation MAPK10 FOXO1 20375467 27042 Regulation MAPK10 ITGB2 21314908 3209841 Regulation MAPK10 MAP2K6 14981092 1306545 Regulation MAPK10 MAP2K6 15184504 1532834 Regulation MAPK10 MAP2K6 17442097 108217 Regulation MAPK10 MAP2K6 20955562 120587 Regulation MAPK10 MAP2K6 22164285 2580321 Regulation MAPK10 MAP2K6 22415879 722059 Regulation MAPK10 MAP2K6 23097702 623110 Regulation MAPK10 MAP2K6 23115639 2711475 Regulation MAPK10 MAP2K6 23704993 2797383 Regulation MAPK10 MAP2K6 24371149 2186352 Regulation MAPK10 MMP28 15841081 425598 Regulation MAPK10 MMP7 15841081 425613 Regulation MAPK10 MUC16 23694968 3135846 Regulation MAPK10 NGFR 22880054 2673903 Regulation MAPK10 PGC 22829833 1068750 Regulation MAPK10 PTGER2 25327961 216551 Regulation MAPK10 RARB 18445634 2034358 Regulation MAPK10 RCAN1 19124655 1553374 Regulation MAPK10 RGS2 18067675 461889 Regulation MAPK10 RGS2 24743392 2955375 Regulation MAPK10 S100B 22276098 2589846 Regulation MAPK10 SARM1 21850204 1057554 Regulation MAPK10 SLC6A2 18509476 2389910 Regulation MAPK10 SPHK1 20498849 2451146 Regulation MAPK10 SPHK1 20498849 2451180 Regulation MAPK10 TLR7 19043549 3042627 Regulation MAPK10 TLR7 20832340 1040252 Regulation MAPK10 TLR7 22829768 3058064 Regulation MAPK10 TLR7 22829768 3058491 Regulation MAPK10 TNF 15175101 523673 Regulation MAPK10 TNF 15642133 102201 Regulation MAPK10 TNF 16207331 104252 Regulation MAPK10 TNF 16542479 105588 Regulation MAPK10 TNF 21572963 2520276 Regulation MAPK10 TNF 22973314 1069003 Regulation MAPK10 TNF 23326019 1751344 Regulation MAPK10 TNF 24304472 1482111 Regulation MAPK10 TNF 24614867 2933208 Regulation MAPK11 ALOX5 25025775 2989425 Regulation MAPK11 ANGPT1 25329960 3017052 Regulation MAPK11 CD14 21387014 2506197 Regulation MAPK11 CHI3L1 23755018 961401 Regulation MAPK11 EPHB2 18648505 2393342 Regulation MAPK11 EPHB2 20100173 212600 Regulation MAPK11 EPHB2 21411626 1788953 Regulation MAPK11 EPHB2 22182854 1720479 Regulation MAPK11 EPHB2 24005988 658070 Regulation MAPK11 FAS 21975294 552748 Regulation MAPK11 FAS 21975294 552749 Regulation MAPK11 FAS 23029562 2698804 Regulation MAPK11 FOXO1 20375467 27046 Regulation MAPK11 ITGB2 21314908 3209842 Regulation MAPK11 MAP2K6 14981092 1306553 Regulation MAPK11 MAP2K6 15184504 1532835 Regulation MAPK11 MAP2K6 17442097 108219 Regulation MAPK11 MAP2K6 20955562 120589 Regulation MAPK11 MAP2K6 22164285 2580322 Regulation MAPK11 MAP2K6 22415879 722062 Regulation MAPK11 MAP2K6 23097702 623118 Regulation MAPK11 MAP2K6 23115639 2711477 Regulation MAPK11 MAP2K6 23704993 2797390 Regulation MAPK11 MAP2K6 24371149 2186359 Regulation MAPK11 MMP28 15841081 425620 Regulation MAPK11 MMP7 15841081 425635 Regulation MAPK11 MUC16 23694968 3135847 Regulation MAPK11 NGFR 22880054 2673905 Regulation MAPK11 PGC 22829833 1068751 Regulation MAPK11 PTGER2 25327961 216552 Regulation MAPK11 RARB 18445634 2034360 Regulation MAPK11 RCAN1 19124655 1553375 Regulation MAPK11 RGS2 18067675 461890 Regulation MAPK11 RGS2 24743392 2955377 Regulation MAPK11 S100B 22276098 2589848 Regulation MAPK11 SARM1 21850204 1057555 Regulation MAPK11 SLC6A2 18509476 2389911 Regulation MAPK11 SPHK1 20498849 2451147 Regulation MAPK11 SPHK1 20498849 2451181 Regulation MAPK11 TLR7 19043549 3042637 Regulation MAPK11 TLR7 20832340 1040253 Regulation MAPK11 TLR7 22829768 3058074 Regulation MAPK11 TLR7 22829768 3058501 Regulation MAPK11 TNF 15175101 523674 Regulation MAPK11 TNF 15642133 102203 Regulation MAPK11 TNF 16207331 104253 Regulation MAPK11 TNF 16542479 105589 Regulation MAPK11 TNF 21572963 2520277 Regulation MAPK11 TNF 22973314 1069007 Regulation MAPK11 TNF 23326019 1751345 Regulation MAPK11 TNF 24304472 1482112 Regulation MAPK11 TNF 24614867 2933209 Regulation MAPK12 ALOX5 25025775 2989426 Regulation MAPK12 ANGPT1 25329960 3017054 Regulation MAPK12 CD14 21387014 2506198 Regulation MAPK12 CHI3L1 23755018 961402 Regulation MAPK12 EPHB2 18648505 2393343 Regulation MAPK12 EPHB2 20100173 212601 Regulation MAPK12 EPHB2 21411626 1788954 Regulation MAPK12 EPHB2 22182854 1720481 Regulation MAPK12 EPHB2 24005988 658071 Regulation MAPK12 FAS 21975294 552750 Regulation MAPK12 FAS 21975294 552751 Regulation MAPK12 FAS 23029562 2698805 Regulation MAPK12 FOXO1 20375467 27050 Regulation MAPK12 ITGB2 21314908 3209843 Regulation MAPK12 MAP2K6 14981092 1306561 Regulation MAPK12 MAP2K6 15184504 1532836 Regulation MAPK12 MAP2K6 17442097 108221 Regulation MAPK12 MAP2K6 20955562 120591 Regulation MAPK12 MAP2K6 22164285 2580323 Regulation MAPK12 MAP2K6 22415879 722065 Regulation MAPK12 MAP2K6 23097702 623126 Regulation MAPK12 MAP2K6 23115639 2711479 Regulation MAPK12 MAP2K6 23704993 2797397 Regulation MAPK12 MAP2K6 24371149 2186366 Regulation MAPK12 MMP28 15841081 425642 Regulation MAPK12 MMP7 15841081 425657 Regulation MAPK12 MUC16 23694968 3135848 Regulation MAPK12 NGFR 22880054 2673907 Regulation MAPK12 PGC 22829833 1068752 Regulation MAPK12 PTGER2 25327961 216553 Regulation MAPK12 RARB 18445634 2034362 Regulation MAPK12 RCAN1 19124655 1553376 Regulation MAPK12 RGS2 18067675 461891 Regulation MAPK12 RGS2 24743392 2955379 Regulation MAPK12 S100B 22276098 2589850 Regulation MAPK12 SARM1 21850204 1057556 Regulation MAPK12 SLC6A2 18509476 2389912 Regulation MAPK12 SPHK1 20498849 2451148 Regulation MAPK12 SPHK1 20498849 2451182 Regulation MAPK12 TLR7 19043549 3042647 Regulation MAPK12 TLR7 20832340 1040254 Regulation MAPK12 TLR7 22829768 3058084 Regulation MAPK12 TLR7 22829768 3058511 Regulation MAPK12 TNF 15175101 523675 Regulation MAPK12 TNF 15642133 102205 Regulation MAPK12 TNF 16207331 104254 Regulation MAPK12 TNF 16542479 105590 Regulation MAPK12 TNF 21572963 2520278 Regulation MAPK12 TNF 22973314 1069011 Regulation MAPK12 TNF 23326019 1751346 Regulation MAPK12 TNF 24304472 1482113 Regulation MAPK12 TNF 24614867 2933210 Regulation MAPK13 ALOX5 25025775 2989427 Regulation MAPK13 ANGPT1 25329960 3017056 Regulation MAPK13 CD14 21387014 2506199 Regulation MAPK13 CHI3L1 23755018 961403 Regulation MAPK13 EPHB2 18648505 2393344 Regulation MAPK13 EPHB2 20100173 212602 Regulation MAPK13 EPHB2 21411626 1788955 Regulation MAPK13 EPHB2 22182854 1720483 Regulation MAPK13 EPHB2 24005988 658072 Regulation MAPK13 FAS 21975294 552752 Regulation MAPK13 FAS 21975294 552753 Regulation MAPK13 FAS 23029562 2698806 Regulation MAPK13 FOXO1 20375467 27054 Regulation MAPK13 ITGB2 21314908 3209844 Regulation MAPK13 MAP2K6 14981092 1306569 Regulation MAPK13 MAP2K6 15184504 1532837 Regulation MAPK13 MAP2K6 17442097 108223 Regulation MAPK13 MAP2K6 20955562 120593 Regulation MAPK13 MAP2K6 22164285 2580324 Regulation MAPK13 MAP2K6 22415879 722068 Regulation MAPK13 MAP2K6 23097702 623134 Regulation MAPK13 MAP2K6 23115639 2711481 Regulation MAPK13 MAP2K6 23704993 2797404 Regulation MAPK13 MAP2K6 24371149 2186373 Regulation MAPK13 MMP28 15841081 425664 Regulation MAPK13 MMP7 15841081 425679 Regulation MAPK13 MUC16 23694968 3135849 Regulation MAPK13 NGFR 22880054 2673909 Regulation MAPK13 PGC 22829833 1068753 Regulation MAPK13 PTGER2 25327961 216554 Regulation MAPK13 RARB 18445634 2034364 Regulation MAPK13 RCAN1 19124655 1553377 Regulation MAPK13 RGS2 18067675 461892 Regulation MAPK13 RGS2 24743392 2955381 Regulation MAPK13 S100B 22276098 2589852 Regulation MAPK13 SARM1 21850204 1057557 Regulation MAPK13 SLC6A2 18509476 2389913 Regulation MAPK13 SPHK1 20498849 2451149 Regulation MAPK13 SPHK1 20498849 2451183 Regulation MAPK13 TLR7 19043549 3042657 Regulation MAPK13 TLR7 20832340 1040255 Regulation MAPK13 TLR7 22829768 3058094 Regulation MAPK13 TLR7 22829768 3058521 Regulation MAPK13 TNF 15175101 523676 Regulation MAPK13 TNF 15642133 102207 Regulation MAPK13 TNF 16207331 104255 Regulation MAPK13 TNF 16542479 105591 Regulation MAPK13 TNF 21572963 2520279 Regulation MAPK13 TNF 22973314 1069015 Regulation MAPK13 TNF 23326019 1751347 Regulation MAPK13 TNF 24304472 1482114 Regulation MAPK13 TNF 24614867 2933211 Regulation MAPK14 ALOX5 25025775 2989428 Regulation MAPK14 ANGPT1 25329960 3017058 Regulation MAPK14 CD14 21387014 2506200 Regulation MAPK14 CHI3L1 23755018 961404 Regulation MAPK14 EPHB2 18648505 2393345 Regulation MAPK14 EPHB2 20100173 212603 Regulation MAPK14 EPHB2 21411626 1788956 Regulation MAPK14 EPHB2 22182854 1720485 Regulation MAPK14 EPHB2 24005988 658073 Regulation MAPK14 FAS 21975294 552754 Regulation MAPK14 FAS 21975294 552755 Regulation MAPK14 FAS 23029562 2698807 Regulation MAPK14 FOXO1 20375467 27058 Regulation MAPK14 ITGB2 21314908 3209845 Regulation MAPK14 MAP2K6 14981092 1306577 Regulation MAPK14 MAP2K6 15184504 1532838 Regulation MAPK14 MAP2K6 17442097 108225 Regulation MAPK14 MAP2K6 20955562 120595 Regulation MAPK14 MAP2K6 22164285 2580325 Regulation MAPK14 MAP2K6 22415879 722071 Regulation MAPK14 MAP2K6 23097702 623142 Regulation MAPK14 MAP2K6 23115639 2711483 Regulation MAPK14 MAP2K6 23704993 2797411 Regulation MAPK14 MAP2K6 24371149 2186380 Regulation MAPK14 MMP28 15841081 425686 Regulation MAPK14 MMP7 15841081 425701 Regulation MAPK14 MUC16 23694968 3135850 Regulation MAPK14 NGFR 22880054 2673911 Regulation MAPK14 PGC 22829833 1068754 Regulation MAPK14 PTGER2 25327961 216555 Regulation MAPK14 RARB 18445634 2034366 Regulation MAPK14 RCAN1 19124655 1553378 Regulation MAPK14 RGS2 18067675 461893 Regulation MAPK14 RGS2 24743392 2955383 Regulation MAPK14 S100B 22276098 2589854 Regulation MAPK14 SARM1 21850204 1057558 Regulation MAPK14 SLC6A2 18509476 2389914 Regulation MAPK14 SPHK1 20498849 2451150 Regulation MAPK14 SPHK1 20498849 2451184 Regulation MAPK14 TLR7 19043549 3042667 Regulation MAPK14 TLR7 20832340 1040256 Regulation MAPK14 TLR7 22829768 3058104 Regulation MAPK14 TLR7 22829768 3058531 Regulation MAPK14 TNF 15175101 523677 Regulation MAPK14 TNF 15642133 102209 Regulation MAPK14 TNF 16207331 104256 Regulation MAPK14 TNF 16542479 105592 Regulation MAPK14 TNF 21572963 2520280 Regulation MAPK14 TNF 22973314 1069019 Regulation MAPK14 TNF 23326019 1751348 Regulation MAPK14 TNF 24304472 1482115 Regulation MAPK14 TNF 24614867 2933212 Regulation MAPK15 ALOX5 25025775 2989421 Regulation MAPK15 ANGPT1 25329960 3017040 Regulation MAPK15 CD14 21387014 2506194 Regulation MAPK15 CHI3L1 23755018 961398 Regulation MAPK15 EPHB2 18648505 2393280 Regulation MAPK15 EPHB2 20100173 212597 Regulation MAPK15 EPHB2 21411626 1788950 Regulation MAPK15 EPHB2 22182854 1720438 Regulation MAPK15 EPHB2 24005988 658067 Regulation MAPK15 FAS 21975294 552742 Regulation MAPK15 FAS 21975294 552743 Regulation MAPK15 FAS 23029562 2698801 Regulation MAPK15 FOXO1 20375467 27010 Regulation MAPK15 ITGB2 21314908 3209839 Regulation MAPK15 MAP2K6 14981092 1306521 Regulation MAPK15 MAP2K6 15184504 1532832 Regulation MAPK15 MAP2K6 17442097 108213 Regulation MAPK15 MAP2K6 20955562 120583 Regulation MAPK15 MAP2K6 22164285 2580319 Regulation MAPK15 MAP2K6 22415879 722053 Regulation MAPK15 MAP2K6 23097702 623094 Regulation MAPK15 MAP2K6 23115639 2711471 Regulation MAPK15 MAP2K6 23704993 2797278 Regulation MAPK15 MAP2K6 24371149 2186338 Regulation MAPK15 MMP28 15841081 425554 Regulation MAPK15 MMP7 15841081 425569 Regulation MAPK15 MUC16 23694968 3135844 Regulation MAPK15 NGFR 22880054 2673893 Regulation MAPK15 PGC 22829833 1068748 Regulation MAPK15 PTGER2 25327961 216548 Regulation MAPK15 RARB 18445634 2034354 Regulation MAPK15 RCAN1 19124655 1553365 Regulation MAPK15 RGS2 18067675 461887 Regulation MAPK15 RGS2 24743392 2955369 Regulation MAPK15 S100B 22276098 2589842 Regulation MAPK15 SARM1 21850204 1057552 Regulation MAPK15 SLC6A2 18509476 2389907 Regulation MAPK15 SPHK1 20498849 2451144 Regulation MAPK15 SPHK1 20498849 2451178 Regulation MAPK15 TLR7 19043549 3042607 Regulation MAPK15 TLR7 20832340 1040243 Regulation MAPK15 TLR7 22829768 3058044 Regulation MAPK15 TLR7 22829768 3058470 Regulation MAPK15 TNF 15175101 523671 Regulation MAPK15 TNF 15642133 102197 Regulation MAPK15 TNF 16207331 104250 Regulation MAPK15 TNF 16542479 105586 Regulation MAPK15 TNF 21572963 2520274 Regulation MAPK15 TNF 22973314 1068923 Regulation MAPK15 TNF 23326019 1751341 Regulation MAPK15 TNF 24304472 1482108 Regulation MAPK15 TNF 24614867 2933206 Regulation MAPK3 ALOX5 25025775 2989429 Regulation MAPK3 ANGPT1 25329960 3017060 Regulation MAPK3 CAPN8 23825596 2809787 Regulation MAPK3 CCND1 24004818 1618330 Regulation MAPK3 CD14 21387014 2506201 Regulation MAPK3 CHI3L1 22211103 1058708 Regulation MAPK3 CHI3L1 23755018 961405 Regulation MAPK3 CTGF 23383241 2749630 Regulation MAPK3 EFNB1 21795402 1793162 Regulation MAPK3 EFNB1 21795402 1793226 Regulation MAPK3 EFNB1 21795402 1793240 Regulation MAPK3 EFNB1 24098442 2856360 Regulation MAPK3 EFNB1 24098442 2856361 Regulation MAPK3 EPHB2 18648505 2393346 Regulation MAPK3 EPHB2 20100173 212604 Regulation MAPK3 EPHB2 21411626 1788957 Regulation MAPK3 EPHB2 21989417 1041861 Regulation MAPK3 EPHB2 22182854 1720487 Regulation MAPK3 EPHB2 23118219 1205520 Regulation MAPK3 EPHB2 24005988 658074 Regulation MAPK3 FAS 21975294 552756 Regulation MAPK3 FAS 21975294 552757 Regulation MAPK3 FAS 23029562 2698808 Regulation MAPK3 FOXO1 20375467 27062 Regulation MAPK3 HBEGF 22984591 2689356 Regulation MAPK3 ITGB2 21314908 3209846 Regulation MAPK3 MAP2K6 14981092 1306585 Regulation MAPK3 MAP2K6 15184504 1532839 Regulation MAPK3 MAP2K6 15353558 1533402 Regulation MAPK3 MAP2K6 16103225 1323248 Regulation MAPK3 MAP2K6 17442097 108227 Regulation MAPK3 MAP2K6 18662930 90784 Regulation MAPK3 MAP2K6 18662930 90785 Regulation MAPK3 MAP2K6 18662930 90786 Regulation MAPK3 MAP2K6 19043603 3074806 Regulation MAPK3 MAP2K6 19575782 283065 Regulation MAPK3 MAP2K6 19575782 283066 Regulation MAPK3 MAP2K6 19575782 283131 Regulation MAPK3 MAP2K6 19575782 283144 Regulation MAPK3 MAP2K6 19575782 283163 Regulation MAPK3 MAP2K6 19619605 833470 Regulation MAPK3 MAP2K6 20034375 1676702 Regulation MAPK3 MAP2K6 20674313 2114173 Regulation MAPK3 MAP2K6 20955562 120597 Regulation MAPK3 MAP2K6 21699731 1862616 Regulation MAPK3 MAP2K6 21833779 3323 Regulation MAPK3 MAP2K6 22164285 2580326 Regulation MAPK3 MAP2K6 22348085 2596826 Regulation MAPK3 MAP2K6 22415879 722074 Regulation MAPK3 MAP2K6 22545230 3163637 Regulation MAPK3 MAP2K6 22754300 1095913 Regulation MAPK3 MAP2K6 22909302 138149 Regulation MAPK3 MAP2K6 23049945 2699929 Regulation MAPK3 MAP2K6 23097702 623150 Regulation MAPK3 MAP2K6 23115639 2711485 Regulation MAPK3 MAP2K6 23166699 2718608 Regulation MAPK3 MAP2K6 23457297 1206637 Regulation MAPK3 MAP2K6 23675062 1064465 Regulation MAPK3 MAP2K6 23704993 2797418 Regulation MAPK3 MAP2K6 23840250 820753 Regulation MAPK3 MAP2K6 23907465 564616 Regulation MAPK3 MAP2K6 24030148 566065 Regulation MAPK3 MAP2K6 24371149 2186387 Regulation MAPK3 MAP2K6 25026288 2196122 Regulation MAPK3 MAP2K6 25050339 195167 Regulation MAPK3 MAP2K6 25193864 2199028 Regulation MAPK3 MAP2K6 25193864 2199029 Regulation MAPK3 MAP2K6 25330306 3017452 Regulation MAPK3 MIP 17233909 351826 Regulation MAPK3 MMP28 15841081 425708 Regulation MAPK3 MMP7 15841081 425723 Regulation MAPK3 MUC16 23694968 3135815 Regulation MAPK3 MUC16 23694968 3135851 Regulation MAPK3 NES 23928293 3169648 Regulation MAPK3 NGFR 22880054 2673913 Regulation MAPK3 PGC 22829833 1068755 Regulation MAPK3 PLAU 24481457 571868 Regulation MAPK3 PTGER2 25327961 216556 Regulation MAPK3 RARB 18445634 2034368 Regulation MAPK3 RCAN1 19124655 1553379 Regulation MAPK3 RGS2 18067675 461894 Regulation MAPK3 RGS2 24743392 2955385 Regulation MAPK3 S100B 22276098 2589856 Regulation MAPK3 SARM1 21850204 1057559 Regulation MAPK3 SLC6A2 18509476 2389915 Regulation MAPK3 SPHK1 20498849 2451151 Regulation MAPK3 SPHK1 20498849 2451185 Regulation MAPK3 SPHK1 20634980 2455779 Regulation MAPK3 SPHK1 20634980 2455812 Regulation MAPK3 STK39 10587355 1513539 Regulation MAPK3 TLR7 19043549 3042677 Regulation MAPK3 TLR7 20832340 1040257 Regulation MAPK3 TLR7 22829768 3058114 Regulation MAPK3 TLR7 22829768 3058541 Regulation MAPK3 TLR7 23527104 2769520 Regulation MAPK3 TNF 10359585 1511870 Regulation MAPK3 TNF 15175101 523678 Regulation MAPK3 TNF 15642133 102211 Regulation MAPK3 TNF 16207331 104257 Regulation MAPK3 TNF 16542479 105593 Regulation MAPK3 TNF 18822184 3212654 Regulation MAPK3 TNF 19808894 711371 Regulation MAPK3 TNF 19808894 711372 Regulation MAPK3 TNF 19808894 711373 Regulation MAPK3 TNF 19808894 711374 Regulation MAPK3 TNF 19808894 711375 Regulation MAPK3 TNF 19808894 711376 Regulation MAPK3 TNF 19808894 711456 Regulation MAPK3 TNF 21572963 2520281 Regulation MAPK3 TNF 22973314 1069023 Regulation MAPK3 TNF 23326019 1751349 Regulation MAPK3 TNF 24039713 2844649 Regulation MAPK3 TNF 24304472 1482116 Regulation MAPK3 TNF 24614867 2933213 Regulation MAPK3 TNFSF10 24466325 2914334 Regulation MAPK4 ALOX5 25025775 2989430 Regulation MAPK4 ANGPT1 25329960 3017062 Regulation MAPK4 CD14 21387014 2506202 Regulation MAPK4 CHI3L1 23755018 961406 Regulation MAPK4 EPHB2 18648505 2393347 Regulation MAPK4 EPHB2 20100173 212605 Regulation MAPK4 EPHB2 21411626 1788958 Regulation MAPK4 EPHB2 22182854 1720489 Regulation MAPK4 EPHB2 24005988 658075 Regulation MAPK4 FAS 21975294 552758 Regulation MAPK4 FAS 21975294 552759 Regulation MAPK4 FAS 23029562 2698809 Regulation MAPK4 FOXO1 20375467 27066 Regulation MAPK4 ITGB2 21314908 3209847 Regulation MAPK4 MAP2K6 14981092 1306593 Regulation MAPK4 MAP2K6 15184504 1532840 Regulation MAPK4 MAP2K6 17442097 108229 Regulation MAPK4 MAP2K6 20955562 120599 Regulation MAPK4 MAP2K6 22164285 2580327 Regulation MAPK4 MAP2K6 22415879 722077 Regulation MAPK4 MAP2K6 23097702 623158 Regulation MAPK4 MAP2K6 23115639 2711487 Regulation MAPK4 MAP2K6 23704993 2797425 Regulation MAPK4 MAP2K6 24371149 2186394 Regulation MAPK4 MMP28 15841081 425730 Regulation MAPK4 MMP7 15841081 425745 Regulation MAPK4 MUC16 23694968 3135852 Regulation MAPK4 NGFR 22880054 2673915 Regulation MAPK4 PGC 22829833 1068756 Regulation MAPK4 PTGER2 25327961 216557 Regulation MAPK4 RARB 18445634 2034370 Regulation MAPK4 RCAN1 19124655 1553380 Regulation MAPK4 RGS2 18067675 461895 Regulation MAPK4 RGS2 24743392 2955387 Regulation MAPK4 S100B 22276098 2589872 Regulation MAPK4 SARM1 21850204 1057560 Regulation MAPK4 SLC6A2 18509476 2389916 Regulation MAPK4 SPHK1 20498849 2451152 Regulation MAPK4 SPHK1 20498849 2451186 Regulation MAPK4 TLR7 19043549 3042687 Regulation MAPK4 TLR7 20832340 1040258 Regulation MAPK4 TLR7 22829768 3058124 Regulation MAPK4 TLR7 22829768 3058551 Regulation MAPK4 TNF 15175101 523679 Regulation MAPK4 TNF 15642133 102213 Regulation MAPK4 TNF 16207331 104258 Regulation MAPK4 TNF 16542479 105594 Regulation MAPK4 TNF 21572963 2520282 Regulation MAPK4 TNF 22973314 1069027 Regulation MAPK4 TNF 23326019 1751350 Regulation MAPK4 TNF 24304472 1482117 Regulation MAPK4 TNF 24614867 2933214 Regulation MAPK6 ALOX5 25025775 2989431 Regulation MAPK6 ANGPT1 25329960 3017064 Regulation MAPK6 CD14 21387014 2506203 Regulation MAPK6 CHI3L1 23755018 961407 Regulation MAPK6 EPHB2 18648505 2393348 Regulation MAPK6 EPHB2 20100173 212606 Regulation MAPK6 EPHB2 21411626 1788959 Regulation MAPK6 EPHB2 22182854 1720491 Regulation MAPK6 EPHB2 24005988 658076 Regulation MAPK6 FAS 21975294 552760 Regulation MAPK6 FAS 21975294 552761 Regulation MAPK6 FAS 23029562 2698810 Regulation MAPK6 FOXO1 20375467 27070 Regulation MAPK6 ITGB2 21314908 3209848 Regulation MAPK6 MAP2K6 14981092 1306601 Regulation MAPK6 MAP2K6 15184504 1532841 Regulation MAPK6 MAP2K6 17442097 108231 Regulation MAPK6 MAP2K6 20955562 120601 Regulation MAPK6 MAP2K6 22164285 2580328 Regulation MAPK6 MAP2K6 22415879 722080 Regulation MAPK6 MAP2K6 23097702 623166 Regulation MAPK6 MAP2K6 23115639 2711489 Regulation MAPK6 MAP2K6 23704993 2797432 Regulation MAPK6 MAP2K6 24371149 2186401 Regulation MAPK6 MMP28 15841081 425752 Regulation MAPK6 MMP7 15841081 425767 Regulation MAPK6 MUC16 23694968 3135853 Regulation MAPK6 NGFR 22880054 2673917 Regulation MAPK6 PGC 22829833 1068757 Regulation MAPK6 PTGER2 25327961 216558 Regulation MAPK6 RARB 18445634 2034372 Regulation MAPK6 RCAN1 19124655 1553381 Regulation MAPK6 RGS2 18067675 461896 Regulation MAPK6 RGS2 24743392 2955389 Regulation MAPK6 S100B 22276098 2589874 Regulation MAPK6 SARM1 21850204 1057561 Regulation MAPK6 SLC6A2 18509476 2389917 Regulation MAPK6 SPHK1 20498849 2451153 Regulation MAPK6 SPHK1 20498849 2451187 Regulation MAPK6 TLR7 19043549 3042697 Regulation MAPK6 TLR7 20832340 1040259 Regulation MAPK6 TLR7 22829768 3058134 Regulation MAPK6 TLR7 22829768 3058561 Regulation MAPK6 TNF 15175101 523680 Regulation MAPK6 TNF 15642133 102215 Regulation MAPK6 TNF 16207331 104259 Regulation MAPK6 TNF 16542479 105595 Regulation MAPK6 TNF 21572963 2520283 Regulation MAPK6 TNF 22973314 1069031 Regulation MAPK6 TNF 23326019 1751351 Regulation MAPK6 TNF 24304472 1482118 Regulation MAPK6 TNF 24614867 2933215 Regulation MAPK7 ALOX5 25025775 2989432 Regulation MAPK7 ANGPT1 25329960 3017066 Regulation MAPK7 CD14 21387014 2506204 Regulation MAPK7 CHI3L1 23755018 961408 Regulation MAPK7 EPHB2 18648505 2393349 Regulation MAPK7 EPHB2 20100173 212607 Regulation MAPK7 EPHB2 21411626 1788960 Regulation MAPK7 EPHB2 22182854 1720493 Regulation MAPK7 EPHB2 24005988 658077 Regulation MAPK7 FAS 21975294 552762 Regulation MAPK7 FAS 21975294 552763 Regulation MAPK7 FAS 23029562 2698811 Regulation MAPK7 FOXO1 20375467 27074 Regulation MAPK7 ITGB2 21314908 3209849 Regulation MAPK7 MAP2K6 14981092 1306609 Regulation MAPK7 MAP2K6 15184504 1532842 Regulation MAPK7 MAP2K6 17442097 108233 Regulation MAPK7 MAP2K6 20955562 120603 Regulation MAPK7 MAP2K6 22164285 2580329 Regulation MAPK7 MAP2K6 22415879 722083 Regulation MAPK7 MAP2K6 23097702 623174 Regulation MAPK7 MAP2K6 23115639 2711491 Regulation MAPK7 MAP2K6 23704993 2797439 Regulation MAPK7 MAP2K6 24371149 2186408 Regulation MAPK7 MMP28 15841081 425774 Regulation MAPK7 MMP7 15841081 425789 Regulation MAPK7 MUC16 23694968 3135854 Regulation MAPK7 NGFR 22880054 2673919 Regulation MAPK7 PGC 22829833 1068758 Regulation MAPK7 PTGER2 25327961 216559 Regulation MAPK7 RARB 18445634 2034374 Regulation MAPK7 RCAN1 19124655 1553382 Regulation MAPK7 RGS2 18067675 461897 Regulation MAPK7 RGS2 24743392 2955391 Regulation MAPK7 S100B 22276098 2589876 Regulation MAPK7 SARM1 21850204 1057562 Regulation MAPK7 SLC6A2 18509476 2389918 Regulation MAPK7 SPHK1 20498849 2451154 Regulation MAPK7 SPHK1 20498849 2451188 Regulation MAPK7 TLR7 19043549 3042707 Regulation MAPK7 TLR7 20832340 1040260 Regulation MAPK7 TLR7 22829768 3058144 Regulation MAPK7 TLR7 22829768 3058571 Regulation MAPK7 TNF 15175101 523681 Regulation MAPK7 TNF 15642133 102217 Regulation MAPK7 TNF 16207331 104260 Regulation MAPK7 TNF 16542479 105596 Regulation MAPK7 TNF 21572963 2520284 Regulation MAPK7 TNF 22973314 1069035 Regulation MAPK7 TNF 23326019 1751352 Regulation MAPK7 TNF 24304472 1482119 Regulation MAPK7 TNF 24614867 2933216 Regulation MAPK8 ALOX5 25025775 2989433 Regulation MAPK8 ANGPT1 25329960 3017068 Regulation MAPK8 CD14 21387014 2506205 Regulation MAPK8 CHI3L1 23755018 961409 Regulation MAPK8 EPHB2 18648505 2393350 Regulation MAPK8 EPHB2 20100173 212608 Regulation MAPK8 EPHB2 21411626 1788961 Regulation MAPK8 EPHB2 22182854 1720495 Regulation MAPK8 EPHB2 24005988 658078 Regulation MAPK8 FAS 16818723 1330948 Regulation MAPK8 FAS 21975294 552764 Regulation MAPK8 FAS 21975294 552765 Regulation MAPK8 FAS 23029562 2698812 Regulation MAPK8 FOXO1 20375467 27078 Regulation MAPK8 ITGB2 21314908 3209850 Regulation MAPK8 MAP2K6 14981092 1306617 Regulation MAPK8 MAP2K6 15184504 1532843 Regulation MAPK8 MAP2K6 17442097 108235 Regulation MAPK8 MAP2K6 20955562 120605 Regulation MAPK8 MAP2K6 22164285 2580330 Regulation MAPK8 MAP2K6 22415879 722086 Regulation MAPK8 MAP2K6 23097702 623182 Regulation MAPK8 MAP2K6 23115639 2711493 Regulation MAPK8 MAP2K6 23704993 2797446 Regulation MAPK8 MAP2K6 24371149 2186415 Regulation MAPK8 MMP28 15841081 425796 Regulation MAPK8 MMP7 15841081 425811 Regulation MAPK8 MUC16 23694968 3135855 Regulation MAPK8 NES 22496975 1687893 Regulation MAPK8 NGFR 22880054 2673921 Regulation MAPK8 PGC 22829833 1068759 Regulation MAPK8 PTGER2 25327961 216560 Regulation MAPK8 RARB 18445634 2034376 Regulation MAPK8 RCAN1 19124655 1553383 Regulation MAPK8 RGS2 18067675 461898 Regulation MAPK8 RGS2 24743392 2955393 Regulation MAPK8 S100B 22276098 2589878 Regulation MAPK8 SARM1 21850204 1057563 Regulation MAPK8 SLC6A2 18509476 2389919 Regulation MAPK8 SPHK1 20498849 2451155 Regulation MAPK8 SPHK1 20498849 2451189 Regulation MAPK8 TLR7 19043549 3042717 Regulation MAPK8 TLR7 20832340 1040261 Regulation MAPK8 TLR7 22829768 3058154 Regulation MAPK8 TLR7 22829768 3058581 Regulation MAPK8 TNF 15175101 523682 Regulation MAPK8 TNF 15642133 102219 Regulation MAPK8 TNF 16207331 104261 Regulation MAPK8 TNF 16542479 105597 Regulation MAPK8 TNF 17567906 370633 Regulation MAPK8 TNF 17567906 370634 Regulation MAPK8 TNF 21572963 2520285 Regulation MAPK8 TNF 22973314 1069039 Regulation MAPK8 TNF 23326019 1751353 Regulation MAPK8 TNF 24304472 1482120 Regulation MAPK8 TNF 24614867 2933217 Regulation MAPK8 TNF 24651600 3066459 Regulation MAPK8IP1 SMN2 22669976 1203714 Regulation MAPK8IP1 TNFSF10 21237154 829094 Regulation MAPK9 ALOX5 25025775 2989434 Regulation MAPK9 ANGPT1 25329960 3017070 Regulation MAPK9 CD14 21387014 2506206 Regulation MAPK9 CHI3L1 23755018 961410 Regulation MAPK9 EPHB2 18648505 2393351 Regulation MAPK9 EPHB2 20100173 212609 Regulation MAPK9 EPHB2 21411626 1788962 Regulation MAPK9 EPHB2 22182854 1720497 Regulation MAPK9 EPHB2 24005988 658079 Regulation MAPK9 FAS 21975294 552766 Regulation MAPK9 FAS 21975294 552767 Regulation MAPK9 FAS 23029562 2698813 Regulation MAPK9 FOXO1 20375467 27082 Regulation MAPK9 ITGB2 21314908 3209851 Regulation MAPK9 MAP2K6 14981092 1306625 Regulation MAPK9 MAP2K6 15184504 1532844 Regulation MAPK9 MAP2K6 17442097 108237 Regulation MAPK9 MAP2K6 20955562 120607 Regulation MAPK9 MAP2K6 22164285 2580331 Regulation MAPK9 MAP2K6 22415879 722089 Regulation MAPK9 MAP2K6 23097702 623190 Regulation MAPK9 MAP2K6 23115639 2711495 Regulation MAPK9 MAP2K6 23704993 2797453 Regulation MAPK9 MAP2K6 24371149 2186422 Regulation MAPK9 MMP28 15841081 425818 Regulation MAPK9 MMP7 15841081 425833 Regulation MAPK9 MUC16 23694968 3135856 Regulation MAPK9 NGFR 22880054 2673923 Regulation MAPK9 PGC 22829833 1068760 Regulation MAPK9 PTGER2 25327961 216561 Regulation MAPK9 RARB 18445634 2034378 Regulation MAPK9 RCAN1 19124655 1553384 Regulation MAPK9 RGS2 18067675 461899 Regulation MAPK9 RGS2 24743392 2955395 Regulation MAPK9 S100B 22276098 2589880 Regulation MAPK9 SARM1 21850204 1057564 Regulation MAPK9 SLC6A2 18509476 2389920 Regulation MAPK9 SPHK1 20498849 2451156 Regulation MAPK9 SPHK1 20498849 2451190 Regulation MAPK9 TLR7 19043549 3042727 Regulation MAPK9 TLR7 20832340 1040262 Regulation MAPK9 TLR7 22829768 3058164 Regulation MAPK9 TLR7 22829768 3058591 Regulation MAPK9 TNF 15175101 523683 Regulation MAPK9 TNF 15642133 102221 Regulation MAPK9 TNF 16207331 104262 Regulation MAPK9 TNF 16542479 105598 Regulation MAPK9 TNF 21572963 2520286 Regulation MAPK9 TNF 22973314 1069043 Regulation MAPK9 TNF 23326019 1751354 Regulation MAPK9 TNF 24304472 1482121 Regulation MAPK9 TNF 24614867 2933218 Regulation MAPKAP1 TLR7 24740015 2954151 Regulation MAPKAPK2 TLR7 23901045 1065478 Regulation MARCH5 KRT38 17606867 1341733 Regulation MARCKSL1 FHL1 15113405 231122 Regulation MARCO TLR7 25089703 2994615 Regulation MAS1L ANGPT1 20948563 1079640 Regulation MAST1 TLR7 22783258 902393 Regulation MAST2 TLR7 22783258 902403 Regulation MAST3 TLR7 22783258 902413 Regulation MAST4 TLR7 22783258 902423 Regulation MAT2A IFI27 19025580 1503414 Regulation MATN2 NFIC 24895400 1487895 Regulation MATN2 NFIC 24895400 1487945 Regulation MATN2 NFIX 24895400 1487896 Regulation MAVS TLR7 16785313 1540806 Regulation MBNL1 TNNT2 20071745 2051673 Regulation MBP WNT7A 25170755 3003856 Regulation MBTPS1 EPHB2 21887342 2549358 Regulation MBTPS1 MMP28 25245676 2201786 Regulation MBTPS1 MMP7 25245676 2201802 Regulation MBTPS1 S1PR3 24970177 208737 Regulation MBTPS1 S1PR3 25245676 2201787 Regulation MBTPS1 SPHK1 16636149 1329315 Regulation MBTPS1 SPHK1 20634980 2455734 Regulation MBTPS1 SPHK1 21304987 2501999 Regulation MBTPS1 SPHK1 21668976 305698 Regulation MBTPS1 SPHK1 22654878 901069 Regulation MBTPS1 SPHK1 25133174 196747 Regulation MBTPS1 SPHK1 25153718 2198620 Regulation MBTPS1 SPHK1 25309325 871454 Regulation MBTPS1 SPHK1 25534583 3148490 Regulation MC3R NPNT 19844573 2428918 Regulation MCL1 EPHB2 22253918 2588364 Regulation MCL1 EPHB2 22649777 939980 Regulation MCL1 EPHB2 22751450 1720731 Regulation MCL1 EPHB2 22751450 1720732 Regulation MCL1 EPHB2 22761917 2659240 Regulation MCL1 EPHB2 23056582 2702355 Regulation MCL1 EPHB2 23088735 1698890 Regulation MCL1 EPHB2 23088735 1698891 Regulation MCL1 EPHB2 23088735 1698931 Regulation MCL1 MAP2K6 18769617 2396026 Regulation MCL1 MAP2K6 23088735 1698937 Regulation MCL1 MAP2K6 24263101 569220 Regulation MDM2 FOXO1 18665269 2394239 Regulation MDM2 HBEGF 23236372 2725999 Regulation MDM2 HBEGF 23236372 2726021 Regulation MED1 ALOX5 23991239 2372083 Regulation MED1 EPHB2 21789185 2538092 Regulation MED1 EPHB2 22319481 860897 Regulation MED1 EPHB2 23209347 1750895 Regulation MED1 EPHB2 24045785 3137209 Regulation MED1 EPHB2 24065881 931300 Regulation MED1 EPHB2 25068892 622530 Regulation MED1 IL1B 11132773 1737403 Regulation MED1 MAP2K6 24065881 931306 Regulation MED1 RCAN1 19124655 1553464 Regulation MED1 TF PMC3611773 1616070 Regulation MED1 TLR7 15804356 3104880 Regulation MED1 TLR7 18584038 3073547 Regulation MED1 TLR7 18584038 3074207 Regulation MED1 TNF 11132773 1737402 Regulation MED1 TNF 23824685 2809242 Regulation MED1 TNF 24963279 842236 Regulation MED1 TNF 25275456 2373082 Regulation MED1 TNF 3435705 443462 Regulation MED10 ALOX5 23991239 2372078 Regulation MED10 EPHB2 21789185 2538087 Regulation MED10 EPHB2 23209347 1750891 Regulation MED10 IL1B 11132773 1737393 Regulation MED10 RCAN1 19124655 1553460 Regulation MED10 TF PMC3611773 1616066 Regulation MED10 TLR7 15804356 3104825 Regulation MED10 TLR7 18584038 3073456 Regulation MED10 TLR7 18584038 3074167 Regulation MED10 TNF 11132773 1737392 Regulation MED10 TNF 23824685 2809238 Regulation MED10 TNF 24963279 842221 Regulation MED10 TNF 25275456 2373078 Regulation MED10 TNF 3435705 443458 Regulation MED11 ALOX5 23991239 2372081 Regulation MED11 EPHB2 21789185 2538090 Regulation MED11 EPHB2 23209347 1750894 Regulation MED11 IL1B 11132773 1737399 Regulation MED11 RCAN1 19124655 1553463 Regulation MED11 TF PMC3611773 1616069 Regulation MED11 TLR7 15804356 3104858 Regulation MED11 TLR7 18584038 3073486 Regulation MED11 TLR7 18584038 3074197 Regulation MED11 TNF 11132773 1737398 Regulation MED11 TNF 23824685 2809241 Regulation MED11 TNF 24963279 842230 Regulation MED11 TNF 25275456 2373081 Regulation MED11 TNF 3435705 443461 Regulation MED12 EPHB2 22319481 860871 Regulation MED12 EPHB2 23209347 1750866 Regulation MED12 EPHB2 24045785 3137195 Regulation MED12 EPHB2 24065881 931196 Regulation MED12 FOXA1 21572438 1987552 Regulation MED12 MAP2K6 24065881 931202 Regulation MED12 RCAN1 19124655 1553435 Regulation MED12 TF PMC3611773 1616041 Regulation MED12 TLR7 18584038 3073186 Regulation MED12 TLR7 18584038 3073917 Regulation MED12 TNF 23824685 2809213 Regulation MED12 TNF 25275456 2373053 Regulation MED12 TNF 3435705 443433 Regulation MED13 ALOX5 23991239 2372065 Regulation MED13 EPHB2 21789185 2538074 Regulation MED13 EPHB2 22319481 860881 Regulation MED13 EPHB2 23209347 1750876 Regulation MED13 EPHB2 24045785 3137200 Regulation MED13 EPHB2 24065881 931236 Regulation MED13 IL1B 11132773 1737367 Regulation MED13 MAP2K6 24065881 931242 Regulation MED13 RCAN1 19124655 1553445 Regulation MED13 TF PMC3611773 1616051 Regulation MED13 TLR7 15804356 3104682 Regulation MED13 TLR7 18584038 3073306 Regulation MED13 TLR7 18584038 3074017 Regulation MED13 TNF 11132773 1737366 Regulation MED13 TNF 23824685 2809223 Regulation MED13 TNF 24963279 842182 Regulation MED13 TNF 25275456 2373063 Regulation MED13 TNF 3435705 443443 Regulation MED13L ALOX5 23991239 2372066 Regulation MED13L EPHB2 21789185 2538075 Regulation MED13L EPHB2 23209347 1750877 Regulation MED13L IL1B 11132773 1737369 Regulation MED13L RCAN1 19124655 1553446 Regulation MED13L TF PMC3611773 1616052 Regulation MED13L TLR7 15804356 3104693 Regulation MED13L TLR7 18584038 3073316 Regulation MED13L TLR7 18584038 3074027 Regulation MED13L TNF 11132773 1737368 Regulation MED13L TNF 23824685 2809224 Regulation MED13L TNF 24963279 842185 Regulation MED13L TNF 25275456 2373064 Regulation MED13L TNF 3435705 443444 Regulation MED14 ALOX5 23991239 2372070 Regulation MED14 EPHB2 21789185 2538079 Regulation MED14 EPHB2 22319481 860885 Regulation MED14 EPHB2 23209347 1750881 Regulation MED14 EPHB2 24045785 3137202 Regulation MED14 EPHB2 24049075 2093739 Regulation MED14 EPHB2 24049075 2093781 Regulation MED14 EPHB2 24049075 2093782 Regulation MED14 EPHB2 24065881 931252 Regulation MED14 IL1B 11132773 1737377 Regulation MED14 MAP2K6 24065881 931258 Regulation MED14 RCAN1 19124655 1553450 Regulation MED14 TF PMC3611773 1616056 Regulation MED14 TLR7 15804356 3104737 Regulation MED14 TLR7 18584038 3073356 Regulation MED14 TLR7 18584038 3074067 Regulation MED14 TNF 11132773 1737376 Regulation MED14 TNF 23824685 2809228 Regulation MED14 TNF 24963279 842197 Regulation MED14 TNF 25275456 2373068 Regulation MED14 TNF 3435705 443448 Regulation MED15 ALOX5 23991239 2372059 Regulation MED15 EPHB2 21789185 2538068 Regulation MED15 EPHB2 22319481 860873 Regulation MED15 EPHB2 23209347 1750867 Regulation MED15 EPHB2 24045785 3137196 Regulation MED15 EPHB2 24065881 931204 Regulation MED15 IL1B 11132773 1737355 Regulation MED15 MAP2K6 24065881 931210 Regulation MED15 RCAN1 19124655 1553436 Regulation MED15 TF PMC3611773 1616042 Regulation MED15 TLR7 15804356 3104616 Regulation MED15 TLR7 18584038 3073196 Regulation MED15 TLR7 18584038 3073927 Regulation MED15 TNF 11132773 1737354 Regulation MED15 TNF 23824685 2809214 Regulation MED15 TNF 24963279 842160 Regulation MED15 TNF 25275456 2373054 Regulation MED15 TNF 3435705 443434 Regulation MED16 ALOX5 23991239 2372061 Regulation MED16 EPHB2 21789185 2538070 Regulation MED16 EPHB2 23209347 1750870 Regulation MED16 IL1B 11132773 1737359 Regulation MED16 RCAN1 19124655 1553439 Regulation MED16 TF PMC3611773 1616045 Regulation MED16 TLR7 15804356 3104638 Regulation MED16 TLR7 18584038 3073246 Regulation MED16 TLR7 18584038 3073957 Regulation MED16 TNF 11132773 1737358 Regulation MED16 TNF 23824685 2809217 Regulation MED16 TNF 24963279 842168 Regulation MED16 TNF 25275456 2373057 Regulation MED16 TNF 3435705 443437 Regulation MED17 ALOX5 23991239 2372072 Regulation MED17 EPHB2 21789185 2538081 Regulation MED17 EPHB2 22319481 860889 Regulation MED17 EPHB2 23209347 1750883 Regulation MED17 EPHB2 24045785 3137204 Regulation MED17 EPHB2 24065881 931268 Regulation MED17 IL1B 11132773 1737381 Regulation MED17 MAP2K6 24065881 931274 Regulation MED17 RCAN1 19124655 1553452 Regulation MED17 TF PMC3611773 1616058 Regulation MED17 TLR7 15804356 3104759 Regulation MED17 TLR7 18584038 3073376 Regulation MED17 TLR7 18584038 3074087 Regulation MED17 TNF 11132773 1737380 Regulation MED17 TNF 23824685 2809230 Regulation MED17 TNF 24963279 842203 Regulation MED17 TNF 25275456 2373070 Regulation MED17 TNF 3435705 443450 Regulation MED18 ALOX5 23991239 2372077 Regulation MED18 EPHB2 21789185 2538086 Regulation MED18 EPHB2 23209347 1750890 Regulation MED18 IL1B 11132773 1737391 Regulation MED18 RCAN1 19124655 1553459 Regulation MED18 TF PMC3611773 1616065 Regulation MED18 TLR7 15804356 3104814 Regulation MED18 TLR7 18584038 3073446 Regulation MED18 TLR7 18584038 3074157 Regulation MED18 TNF 11132773 1737390 Regulation MED18 TNF 23824685 2809237 Regulation MED18 TNF 24963279 842218 Regulation MED18 TNF 25275456 2373077 Regulation MED18 TNF 3435705 443457 Regulation MED19 ALOX5 23991239 2372080 Regulation MED19 EPHB2 21789185 2538089 Regulation MED19 EPHB2 23209347 1750893 Regulation MED19 IL1B 11132773 1737397 Regulation MED19 RCAN1 19124655 1553462 Regulation MED19 TF PMC3611773 1616068 Regulation MED19 TLR7 15804356 3104847 Regulation MED19 TLR7 18584038 3073476 Regulation MED19 TLR7 18584038 3074187 Regulation MED19 TNF 11132773 1737396 Regulation MED19 TNF 23824685 2809240 Regulation MED19 TNF 24963279 842227 Regulation MED19 TNF 25275456 2373080 Regulation MED19 TNF 3435705 443460 Regulation MED20 ALOX5 23991239 2372060 Regulation MED20 EPHB2 21789185 2538069 Regulation MED20 EPHB2 23209347 1750869 Regulation MED20 IL1B 11132773 1737357 Regulation MED20 RCAN1 19124655 1553438 Regulation MED20 TF PMC3611773 1616044 Regulation MED20 TLR7 15804356 3104627 Regulation MED20 TLR7 18584038 3073236 Regulation MED20 TLR7 18584038 3073947 Regulation MED20 TNF 11132773 1737356 Regulation MED20 TNF 23824685 2809216 Regulation MED20 TNF 24963279 842165 Regulation MED20 TNF 25275456 2373056 Regulation MED20 TNF 3435705 443436 Regulation MED21 ALOX5 23991239 2372057 Regulation MED21 EPHB2 21789185 2538066 Regulation MED21 EPHB2 22319481 860869 Regulation MED21 EPHB2 23209347 1750864 Regulation MED21 EPHB2 24065881 931188 Regulation MED21 IL1B 11132773 1737351 Regulation MED21 MAP2K6 24065881 931194 Regulation MED21 RCAN1 19124655 1553433 Regulation MED21 TF PMC3611773 1616039 Regulation MED21 TLR7 15804356 3104594 Regulation MED21 TLR7 18584038 3073156 Regulation MED21 TLR7 18584038 3073897 Regulation MED21 TNF 11132773 1737350 Regulation MED21 TNF 23824685 2809211 Regulation MED21 TNF 24963279 842154 Regulation MED21 TNF 25275456 2373051 Regulation MED21 TNF 3435705 443431 Regulation MED22 ALOX5 23991239 2372058 Regulation MED22 EPHB2 21789185 2538067 Regulation MED22 EPHB2 23209347 1750865 Regulation MED22 IL1B 11132773 1737353 Regulation MED22 RCAN1 19124655 1553434 Regulation MED22 TF PMC3611773 1616040 Regulation MED22 TLR7 15804356 3104605 Regulation MED22 TLR7 18584038 3073166 Regulation MED22 TLR7 18584038 3073907 Regulation MED22 TNF 11132773 1737352 Regulation MED22 TNF 23824685 2809212 Regulation MED22 TNF 24963279 842157 Regulation MED22 TNF 25275456 2373052 Regulation MED22 TNF 3435705 443432 Regulation MED23 ALOX5 23991239 2372071 Regulation MED23 EPHB2 21789185 2538080 Regulation MED23 EPHB2 22319481 860887 Regulation MED23 EPHB2 23209347 1750882 Regulation MED23 EPHB2 24045785 3137203 Regulation MED23 EPHB2 24065881 931260 Regulation MED23 IL1B 11132773 1737379 Regulation MED23 MAP2K6 24065881 931266 Regulation MED23 RCAN1 19124655 1553451 Regulation MED23 TF PMC3611773 1616057 Regulation MED23 TLR7 15804356 3104748 Regulation MED23 TLR7 18584038 3073366 Regulation MED23 TLR7 18584038 3074077 Regulation MED23 TNF 11132773 1737378 Regulation MED23 TNF 23824685 2809229 Regulation MED23 TNF 24963279 842200 Regulation MED23 TNF 25275456 2373069 Regulation MED23 TNF 3435705 443449 Regulation MED24 ALOX5 23991239 2372067 Regulation MED24 EPHB2 21789185 2538076 Regulation MED24 EPHB2 22319481 860883 Regulation MED24 EPHB2 23209347 1750878 Regulation MED24 EPHB2 24045785 3137201 Regulation MED24 EPHB2 24065881 931244 Regulation MED24 IL1B 11132773 1737371 Regulation MED24 MAP2K6 24065881 931250 Regulation MED24 RCAN1 19124655 1553447 Regulation MED24 TF PMC3611773 1616053 Regulation MED24 TLR7 15804356 3104704 Regulation MED24 TLR7 18584038 3073326 Regulation MED24 TLR7 18584038 3074037 Regulation MED24 TNF 11132773 1737370 Regulation MED24 TNF 23824685 2809225 Regulation MED24 TNF 24963279 842188 Regulation MED24 TNF 25275456 2373065 Regulation MED24 TNF 3435705 443445 Regulation MED25 ALOX5 23991239 2372079 Regulation MED25 EPHB2 21789185 2538088 Regulation MED25 EPHB2 22319481 860895 Regulation MED25 EPHB2 23209347 1750892 Regulation MED25 EPHB2 24045785 3137207 Regulation MED25 EPHB2 24065881 931292 Regulation MED25 IL1B 11132773 1737395 Regulation MED25 MAP2K6 24065881 931298 Regulation MED25 RCAN1 19124655 1553461 Regulation MED25 TF PMC3611773 1616067 Regulation MED25 TLR7 15804356 3104836 Regulation MED25 TLR7 18584038 3073466 Regulation MED25 TLR7 18584038 3074177 Regulation MED25 TNF 11132773 1737394 Regulation MED25 TNF 23824685 2809239 Regulation MED25 TNF 24963279 842224 Regulation MED25 TNF 25275456 2373079 Regulation MED25 TNF 3435705 443459 Regulation MED26 ALOX5 23991239 2372073 Regulation MED26 EPHB2 21789185 2538082 Regulation MED26 EPHB2 22319481 860891 Regulation MED26 EPHB2 23209347 1750884 Regulation MED26 EPHB2 24045785 3137205 Regulation MED26 EPHB2 24065881 931276 Regulation MED26 IL1B 11132773 1737383 Regulation MED26 MAP2K6 24065881 931282 Regulation MED26 RCAN1 19124655 1553453 Regulation MED26 TF PMC3611773 1616059 Regulation MED26 TLR7 15804356 3104770 Regulation MED26 TLR7 18584038 3073386 Regulation MED26 TLR7 18584038 3074097 Regulation MED26 TNF 11132773 1737382 Regulation MED26 TNF 23824685 2809231 Regulation MED26 TNF 24963279 842206 Regulation MED26 TNF 25275456 2373071 Regulation MED26 TNF 3435705 443451 Regulation MED27 ALOX5 23991239 2372074 Regulation MED27 EPHB2 21789185 2538083 Regulation MED27 EPHB2 23209347 1750885 Regulation MED27 IL1B 11132773 1737385 Regulation MED27 RCAN1 19124655 1553454 Regulation MED27 TF PMC3611773 1616060 Regulation MED27 TLR7 15804356 3104781 Regulation MED27 TLR7 18584038 3073396 Regulation MED27 TLR7 18584038 3074107 Regulation MED27 TNF 11132773 1737384 Regulation MED27 TNF 23824685 2809232 Regulation MED27 TNF 24963279 842209 Regulation MED27 TNF 25275456 2373072 Regulation MED27 TNF 3435705 443452 Regulation MED28 EPHB2 23209347 1750888 Regulation MED28 RCAN1 19124655 1553457 Regulation MED28 TF PMC3611773 1616063 Regulation MED28 TLR7 18584038 3073426 Regulation MED28 TLR7 18584038 3074137 Regulation MED28 TNF 23824685 2809235 Regulation MED28 TNF 25275456 2373075 Regulation MED28 TNF 3435705 443455 Regulation MED29 ALOX5 23991239 2372069 Regulation MED29 EPHB2 21789185 2538078 Regulation MED29 EPHB2 23209347 1750880 Regulation MED29 IL1B 11132773 1737375 Regulation MED29 RCAN1 19124655 1553449 Regulation MED29 TF PMC3611773 1616055 Regulation MED29 TLR7 15804356 3104726 Regulation MED29 TLR7 18584038 3073346 Regulation MED29 TLR7 18584038 3074057 Regulation MED29 TNF 11132773 1737374 Regulation MED29 TNF 23824685 2809227 Regulation MED29 TNF 24963279 842194 Regulation MED29 TNF 25275456 2373067 Regulation MED29 TNF 3435705 443447 Regulation MED30 ALOX5 23991239 2372068 Regulation MED30 EPHB2 21789185 2538077 Regulation MED30 EPHB2 23209347 1750879 Regulation MED30 IL1B 11132773 1737373 Regulation MED30 RCAN1 19124655 1553448 Regulation MED30 TF PMC3611773 1616054 Regulation MED30 TLR7 15804356 3104715 Regulation MED30 TLR7 18584038 3073336 Regulation MED30 TLR7 18584038 3074047 Regulation MED30 TNF 11132773 1737372 Regulation MED30 TNF 23824685 2809226 Regulation MED30 TNF 24963279 842191 Regulation MED30 TNF 25275456 2373066 Regulation MED30 TNF 3435705 443446 Regulation MED31 ALOX5 23991239 2372076 Regulation MED31 EPHB2 21789185 2538085 Regulation MED31 EPHB2 23209347 1750887 Regulation MED31 IL1B 11132773 1737389 Regulation MED31 RCAN1 19124655 1553456 Regulation MED31 TF PMC3611773 1616062 Regulation MED31 TLR7 15804356 3104803 Regulation MED31 TLR7 18584038 3073416 Regulation MED31 TLR7 18584038 3074127 Regulation MED31 TNF 11132773 1737388 Regulation MED31 TNF 23824685 2809234 Regulation MED31 TNF 24963279 842215 Regulation MED31 TNF 25275456 2373074 Regulation MED31 TNF 3435705 443454 Regulation MED4 ALOX5 23991239 2372062 Regulation MED4 EPHB2 21789185 2538071 Regulation MED4 EPHB2 23209347 1750872 Regulation MED4 EPHB2 24045785 3137197 Regulation MED4 IL1B 11132773 1737361 Regulation MED4 RCAN1 19124655 1553441 Regulation MED4 TF PMC3611773 1616047 Regulation MED4 TLR7 15804356 3104649 Regulation MED4 TLR7 18584038 3073266 Regulation MED4 TLR7 18584038 3073977 Regulation MED4 TNF 11132773 1737360 Regulation MED4 TNF 23824685 2809219 Regulation MED4 TNF 24963279 842171 Regulation MED4 TNF 25275456 2373059 Regulation MED4 TNF 3435705 443439 Regulation MED6 ALOX5 23991239 2372063 Regulation MED6 EPHB2 21789185 2538072 Regulation MED6 EPHB2 22319481 860879 Regulation MED6 EPHB2 23209347 1750874 Regulation MED6 EPHB2 24045785 3137198 Regulation MED6 EPHB2 24065881 931228 Regulation MED6 IL1B 11132773 1737363 Regulation MED6 MAP2K6 24065881 931234 Regulation MED6 RCAN1 19124655 1553443 Regulation MED6 TF PMC3611773 1616049 Regulation MED6 TLR7 15804356 3104660 Regulation MED6 TLR7 18584038 3073286 Regulation MED6 TLR7 18584038 3073997 Regulation MED6 TNF 11132773 1737362 Regulation MED6 TNF 23824685 2809221 Regulation MED6 TNF 24963279 842176 Regulation MED6 TNF 25275456 2373061 Regulation MED6 TNF 3435705 443441 Regulation MED7 ALOX5 23991239 2372075 Regulation MED7 EPHB2 21789185 2538084 Regulation MED7 EPHB2 22319481 860893 Regulation MED7 EPHB2 23209347 1750886 Regulation MED7 EPHB2 24045785 3137206 Regulation MED7 EPHB2 24065881 931284 Regulation MED7 IL1B 11132773 1737387 Regulation MED7 MAP2K6 24065881 931290 Regulation MED7 RCAN1 19124655 1553455 Regulation MED7 TF PMC3611773 1616061 Regulation MED7 TLR7 15804356 3104792 Regulation MED7 TLR7 18584038 3073406 Regulation MED7 TLR7 18584038 3074117 Regulation MED7 TNF 11132773 1737386 Regulation MED7 TNF 23824685 2809233 Regulation MED7 TNF 24963279 842212 Regulation MED7 TNF 25275456 2373073 Regulation MED7 TNF 3435705 443453 Regulation MED8 ALOX5 23991239 2372064 Regulation MED8 EPHB2 21789185 2538073 Regulation MED8 EPHB2 23209347 1750875 Regulation MED8 EPHB2 24045785 3137199 Regulation MED8 IL1B 11132773 1737365 Regulation MED8 RCAN1 19124655 1553444 Regulation MED8 TF PMC3611773 1616050 Regulation MED8 TLR7 15804356 3104671 Regulation MED8 TLR7 18584038 3073296 Regulation MED8 TLR7 18584038 3074007 Regulation MED8 TNF 11132773 1737364 Regulation MED8 TNF 23824685 2809222 Regulation MED8 TNF 24963279 842179 Regulation MED8 TNF 25275456 2373062 Regulation MED8 TNF 3435705 443442 Regulation MED9 EPHB2 23209347 1750889 Regulation MED9 RCAN1 19124655 1553458 Regulation MED9 TF PMC3611773 1616064 Regulation MED9 TLR7 18584038 3073436 Regulation MED9 TLR7 18584038 3074147 Regulation MED9 TNF 23824685 2809236 Regulation MED9 TNF 25275456 2373076 Regulation MED9 TNF 3435705 443456 Regulation MEFV FHL1 24219103 151966 Regulation MEFV FHL1 24219103 151967 Regulation MEI1 TLR7 19564352 1555261 Regulation MEI1 TLR7 19564352 1555262 Regulation MEI4 TLR7 19564352 1555281 Regulation MEI4 TLR7 19564352 1555282 Regulation MET FOXO1 21253475 3127973 Regulation METAP2 EPHB2 17984326 1346311 Regulation MFN2 PGC 18974884 2399748 Regulation MFN2 PGC 18974884 2399749 Regulation MFN2 PGC 18974884 2399751 Regulation MFN2 PGC 21274278 1670137 Regulation MFN2 PGC 22742515 212905 Regulation MFN2 PGC 22769563 3161129 Regulation MFN2 PGC 24623376 784460 Regulation MGAM SI 1717481 1335504 Regulation MGAT3 ARSA 24184502 154213 Regulation MICA EPHB2 21935360 2555205 Regulation MICE TNF 23382717 972503 Regulation MICE TNF 9104810 1600612 Regulation MIEN1 PLAU 19503095 2125540 Regulation MIF F2R 21209875 2491651 Regulation MIF TLR7 18723565 90831 Regulation MIF TLR7 23046560 339434 Regulation MIF TNF 21087445 645644 Regulation MIF TNF 21977228 2559767 Regulation MIF TNF 22496958 1680486 Regulation MIF TNF 23675368 878569 Regulation MIP ACD 8315395 1594892 Regulation MIP ADIPOQ 18972601 3231516 Regulation MIP AKT1 24009857 203923 Regulation MIP AKT2 24009857 203924 Regulation MIP AKT3 24009857 203925 Regulation MIP C5 24634797 21397 Regulation MIP CA2 15078916 1607844 Regulation MIP CA2 23893133 1982113 Regulation MIP CALM3 23734214 2799704 Regulation MIP CALM3 23893133 1982114 Regulation MIP CFTR 21301926 1050357 Regulation MIP CFTR 24671173 2946587 Regulation MIP CSF2 8315395 1594891 Regulation MIP CXCL10 22132075 2573993 Regulation MIP EIF1 19413900 3109483 Regulation MIP EPHB2 11877481 1523111 Regulation MIP FEV 24833899 1072156 Regulation MIP FGF2 21698120 2530416 Regulation MIP FPR1 11877481 1523112 Regulation MIP IL10 17634143 108612 Regulation MIP IL11 17634143 108613 Regulation MIP IL13 17634143 108614 Regulation MIP IL15 17634143 108615 Regulation MIP IL16 17634143 108616 Regulation MIP IL17A 21747807 923189 Regulation MIP IL17A 22028860 2564564 Regulation MIP IL18 17634143 108617 Regulation MIP IL19 17634143 108618 Regulation MIP IL2 17634143 108619 Regulation MIP IL2 22132075 2573994 Regulation MIP IL20 17634143 108620 Regulation MIP IL21 17634143 108621 Regulation MIP IL22 17634143 108604 Regulation MIP IL24 17634143 108601 Regulation MIP IL25 17634143 108603 Regulation MIP IL26 17634143 108608 Regulation MIP IL27 17634143 108609 Regulation MIP IL3 17634143 108622 Regulation MIP IL31 17634143 108610 Regulation MIP IL32 17634143 108607 Regulation MIP IL33 17634143 108606 Regulation MIP IL33 23418608 2754897 Regulation MIP IL34 17634143 108611 Regulation MIP IL37 17634143 108605 Regulation MIP IL4 17634143 108623 Regulation MIP IL5 17634143 108624 Regulation MIP IL6 17634143 108625 Regulation MIP IL6 23822633 3113738 Regulation MIP IL7 17634143 108626 Regulation MIP IL8 17634143 108627 Regulation MIP IL9 17634143 108628 Regulation MIP LEP 18972601 3231517 Regulation MIP MAF 17262012 1906236 Regulation MIP MAFB 17262012 1906282 Regulation MIP MAPK1 19781090 1625790 Regulation MIP MAPK10 19781090 1625791 Regulation MIP MAPK11 19781090 1625792 Regulation MIP MAPK12 19781090 1625793 Regulation MIP MAPK13 19781090 1625794 Regulation MIP MAPK14 19781090 1625795 Regulation MIP MAPK15 19781090 1625789 Regulation MIP MAPK3 17316425 658808 Regulation MIP MAPK3 17316425 658810 Regulation MIP MAPK3 19781090 1625796 Regulation MIP MAPK3 22379572 1710336 Regulation MIP MAPK4 19781090 1625797 Regulation MIP MAPK6 19781090 1625798 Regulation MIP MAPK7 19781090 1625799 Regulation MIP MAPK8 19781090 1625800 Regulation MIP MAPK9 19781090 1625801 Regulation MIP MYD88 16304610 3039067 Regulation MIP PIP 20817957 27649 Regulation MIP PITX3 21698120 2530413 Regulation MIP PLA2G4A 23670971 727355 Regulation MIP PRKACB 21298000 2499269 Regulation MIP PRKACB 22095752 776888 Regulation MIP PRKACB 23734214 2799705 Regulation MIP PRKACB 23734214 2799711 Regulation MIP PRKACG 21298000 2499270 Regulation MIP PRKACG 22095752 776889 Regulation MIP PRKACG 23734214 2799706 Regulation MIP PRKACG 23734214 2799712 Regulation MIP PRKAR1A 21298000 2499271 Regulation MIP PRKAR1A 22095752 776890 Regulation MIP PRKAR1A 23734214 2799707 Regulation MIP PRKAR1A 23734214 2799713 Regulation MIP PRKAR1B 21298000 2499272 Regulation MIP PRKAR1B 22095752 776891 Regulation MIP PRKAR1B 23734214 2799708 Regulation MIP PRKAR1B 23734214 2799714 Regulation MIP PRKAR2A 21298000 2499273 Regulation MIP PRKAR2A 22095752 776892 Regulation MIP PRKAR2A 23734214 2799709 Regulation MIP PRKAR2A 23734214 2799715 Regulation MIP PRKAR2B 21298000 2499274 Regulation MIP PRKAR2B 22095752 776893 Regulation MIP PRKAR2B 23734214 2799710 Regulation MIP PRKAR2B 23734214 2799716 Regulation MIP SEA 8496676 1595579 Regulation MIP STAT1 24964861 411215 Regulation MIP STAT1 24964861 411218 Regulation MIP STAT3 24964861 411219 Regulation MIP TGFB1 8394405 1595126 Regulation MIP TLR4 15935092 3105025 Regulation MIP TLR4 21543283 794377 Regulation MIP TNF 17634143 108602 Regulation MIP TNF 19901996 1746819 Regulation MIP TNF 9400717 797370 Regulation MIR155 TLR7 24800233 190000 Regulation MIR221 IFI27 20813046 1858362 Regulation MIR222 IFI27 20813046 1858363 Regulation MIR34A JAG1 24598126 1618818 Regulation MITF EPHB2 21887372 2549623 Regulation MITF EPHB2 21887372 2549709 Regulation MITF EPHB2 25045707 195104 Regulation MITF IFI27 23028343 2338276 Regulation MITF MAP2K6 21887372 2549700 Regulation MITF PGC 24161908 2185142 Regulation MKNK1 EPHB2 19351384 357972 Regulation MKNK1 EPHB2 19690847 828903 Regulation MKNK1 EPHB2 22392765 2179856 Regulation MLST8 EPHB2 21200439 2489528 Regulation MLST8 EPHB2 21283628 2497007 Regulation MLST8 EPHB2 22028687 860563 Regulation MLST8 EPHB2 23197407 779549 Regulation MLST8 EPHB2 23431403 2755372 Regulation MLST8 EPHB2 23431403 2755434 Regulation MLST8 EPHB2 24303063 2887911 Regulation MLST8 FOXO1 23183047 1570151 Regulation MLST8 FOXO1 24498161 2918733 Regulation MLST8 MAP2K6 22564882 2180124 Regulation MLST8 PGC 24352740 2212458 Regulation MLST8 RAB31 22523661 1670359 Regulation MLST8 TLR7 24740015 2954171 Regulation MLXIPL CCND1 22751438 541606 Regulation MLXIPL CCND1 22751438 541614 Regulation MLXIPL CCND1 22951541 541913 Regulation MLXIPL FOXO1 23056614 2702407 Regulation MLXIPL FOXO1 23056614 2702410 Regulation MME EPHB2 22767595 1204021 Regulation MME MAP2K6 22767595 1204027 Regulation MMP1 AGR2 17129374 107456 Regulation MMP1 CAPN8 21501525 1505088 Regulation MMP1 EPHB2 21320340 258847 Regulation MMP1 EPHB2 21738525 922820 Regulation MMP1 MMP28 19375502 1731667 Regulation MMP1 NES 24819052 2968707 Regulation MMP1 PECAM1 12591918 1291207 Regulation MMP1 PLAT 23565108 935281 Regulation MMP1 PLAT 24303218 2003310 Regulation MMP1 PLAU 24189182 787885 Regulation MMP1 TFPI2 23905012 853468 Regulation MMP1 TGM2 24130925 204526 Regulation MMP1 TLR7 17129374 107450 Regulation MMP1 TNF 11879548 98702 Regulation MMP1 TNF 11879548 98703 Regulation MMP1 TNF 11879548 98704 Regulation MMP1 TNF 15043753 3095702 Regulation MMP1 TNF 17118171 3096374 Regulation MMP1 TNF 18852869 1908432 Regulation MMP1 TNF 19627579 116239 Regulation MMP1 TNF 19889233 3097688 Regulation MMP1 TNF 21067565 397474 Regulation MMP1 TNF 21067565 397476 Regulation MMP1 TNF 21547259 1749191 Regulation MMP1 TNF 21912722 2223899 Regulation MMP1 TNF 22367096 650839 Regulation MMP1 TNF 23389627 1811860 Regulation MMP1 TNF 23750094 163629 Regulation MMP1 TNF 24062615 1628901 Regulation MMP1 TNF 24144354 651707 Regulation MMP1 TNF 24926361 844521 Regulation MMP1 TNF 25250141 1148980 Regulation MMP1 TNF 25457675 805859 Regulation MMP1 TNFSF10 24611063 911510 Regulation MMP1 TSPAN1 10491398 1250428 Regulation MMP1 WNT7A 24479426 131550 Regulation MMP10 AGR2 17129374 107468 Regulation MMP10 CAPN8 21501525 1505102 Regulation MMP10 EPHB2 21320340 258866 Regulation MMP10 EPHB2 21738525 922821 Regulation MMP10 MMP28 19375502 1731668 Regulation MMP10 PECAM1 12591918 1291208 Regulation MMP10 PLAT 23565108 935282 Regulation MMP10 PLAT 24303218 2003311 Regulation MMP10 PLAU 24189182 787886 Regulation MMP10 TFPI2 23905012 853469 Regulation MMP10 TGM2 24130925 204527 Regulation MMP10 TLR7 17129374 107462 Regulation MMP10 TNF 11237387 418349 Regulation MMP10 TNF 17118171 3096375 Regulation MMP10 TNF 18852869 1908433 Regulation MMP10 TNF 19889233 3097689 Regulation MMP10 TNF 21547259 1749193 Regulation MMP10 TNF 21912722 2223900 Regulation MMP10 TNF 23389627 1811861 Regulation MMP10 TNF 23750094 163630 Regulation MMP10 TNF 24144354 651708 Regulation MMP10 TNF 24926361 844522 Regulation MMP10 TNF 25250141 1148981 Regulation MMP10 TNFSF10 24611063 911521 Regulation MMP10 TSPAN1 10491398 1250450 Regulation MMP10 WNT7A 24479426 131552 Regulation MMP11 AGR2 17129374 107480 Regulation MMP11 CAPN8 21501525 1505116 Regulation MMP11 EPHB2 21320340 258885 Regulation MMP11 EPHB2 21738525 922822 Regulation MMP11 MMP28 19375502 1731669 Regulation MMP11 PECAM1 12591918 1291209 Regulation MMP11 PLAT 23565108 935283 Regulation MMP11 PLAT 24303218 2003312 Regulation MMP11 PLAU 24189182 787887 Regulation MMP11 TFPI2 23905012 853470 Regulation MMP11 TGM2 24130925 204528 Regulation MMP11 TLR7 17129374 107474 Regulation MMP11 TNF 17118171 3096376 Regulation MMP11 TNF 18852869 1908434 Regulation MMP11 TNF 19889233 3097690 Regulation MMP11 TNF 21547259 1749195 Regulation MMP11 TNF 21912722 2223901 Regulation MMP11 TNF 23389627 1811862 Regulation MMP11 TNF 23750094 163631 Regulation MMP11 TNF 24144354 651709 Regulation MMP11 TNF 24926361 844523 Regulation MMP11 TNF 25250141 1148982 Regulation MMP11 TNFSF10 24611063 911532 Regulation MMP11 TSPAN1 10491398 1250472 Regulation MMP11 WNT7A 24479426 131554 Regulation MMP12 AGR2 17129374 107492 Regulation MMP12 CAPN8 21501525 1505130 Regulation MMP12 CD14 15526056 2368213 Regulation MMP12 EPHB2 19144181 112472 Regulation MMP12 EPHB2 21320340 258904 Regulation MMP12 EPHB2 21738525 922823 Regulation MMP12 MAP2K6 19144181 112478 Regulation MMP12 MMP28 19375502 1731670 Regulation MMP12 PECAM1 12591918 1291210 Regulation MMP12 PLAT 23565108 935284 Regulation MMP12 PLAT 24303218 2003313 Regulation MMP12 PLAU 24189182 787888 Regulation MMP12 TFPI2 23905012 853471 Regulation MMP12 TGM2 24130925 204529 Regulation MMP12 TLR7 17129374 107486 Regulation MMP12 TNF 16359550 3105891 Regulation MMP12 TNF 16359550 3105892 Regulation MMP12 TNF 17118171 3096377 Regulation MMP12 TNF 18852869 1908435 Regulation MMP12 TNF 19889233 3097691 Regulation MMP12 TNF 21547259 1749197 Regulation MMP12 TNF 21912722 2223902 Regulation MMP12 TNF 23389627 1811863 Regulation MMP12 TNF 23750094 163632 Regulation MMP12 TNF 24144354 651710 Regulation MMP12 TNF 24926361 844524 Regulation MMP12 TNF 25250141 1148983 Regulation MMP12 TNFSF10 24611063 911543 Regulation MMP12 TSPAN1 10491398 1250494 Regulation MMP12 WNT7A 24479426 131556 Regulation MMP13 AGR2 17129374 107504 Regulation MMP13 CAPN8 21501525 1505144 Regulation MMP13 EPHB2 21246051 2492967 Regulation MMP13 EPHB2 21320340 258923 Regulation MMP13 EPHB2 21738525 922824 Regulation MMP13 F2R 24385683 1756369 Regulation MMP13 IL1B 22018279 124245 Regulation MMP13 MMP28 19375502 1731671 Regulation MMP13 PECAM1 12591918 1291211 Regulation MMP13 PLAT 23565108 935285 Regulation MMP13 PLAT 24303218 2003314 Regulation MMP13 PLAU 24189182 787889 Regulation MMP13 TFPI2 23905012 853472 Regulation MMP13 TGM2 24130925 204530 Regulation MMP13 TLR7 17129374 107498 Regulation MMP13 TNF 17118171 3096378 Regulation MMP13 TNF 18852869 1908436 Regulation MMP13 TNF 19435506 113284 Regulation MMP13 TNF 19627579 116241 Regulation MMP13 TNF 19889233 3097692 Regulation MMP13 TNF 21339857 648059 Regulation MMP13 TNF 21547259 1749199 Regulation MMP13 TNF 21912722 2223903 Regulation MMP13 TNF 22018279 124244 Regulation MMP13 TNF 23389627 1811864 Regulation MMP13 TNF 23750094 163633 Regulation MMP13 TNF 23784308 606152 Regulation MMP13 TNF 24144354 651711 Regulation MMP13 TNF 24926361 844525 Regulation MMP13 TNF 25250141 1148984 Regulation MMP13 TNFSF10 24611063 911554 Regulation MMP13 TSPAN1 10491398 1250516 Regulation MMP13 WNT7A 24479426 131558 Regulation MMP14 AGR2 17129374 107516 Regulation MMP14 CAPN8 21501525 1505158 Regulation MMP14 CAPN8 22407449 87072 Regulation MMP14 EPHB2 19636436 1671453 Regulation MMP14 EPHB2 21320340 258942 Regulation MMP14 EPHB2 21738525 922825 Regulation MMP14 MAP2K6 22310287 2146246 Regulation MMP14 MMP28 18762577 1356241 Regulation MMP14 MMP28 19375502 1731672 Regulation MMP14 MMP28 24156018 492128 Regulation MMP14 MMP7 18762577 1356256 Regulation MMP14 MMP7 24156018 492143 Regulation MMP14 PECAM1 12591918 1291212 Regulation MMP14 PLAT 23565108 935286 Regulation MMP14 PLAT 24303218 2003315 Regulation MMP14 PLAU 24189182 787890 Regulation MMP14 TFPI2 23905012 853473 Regulation MMP14 TGM2 24130925 204531 Regulation MMP14 TLR7 17129374 107510 Regulation MMP14 TNF 15272933 248413 Regulation MMP14 TNF 17118171 3096379 Regulation MMP14 TNF 18852869 1908437 Regulation MMP14 TNF 19889233 3097693 Regulation MMP14 TNF 21547259 1749201 Regulation MMP14 TNF 21912722 2223904 Regulation MMP14 TNF 23389627 1811865 Regulation MMP14 TNF 23750094 163634 Regulation MMP14 TNF 24144354 651712 Regulation MMP14 TNF 24926361 844526 Regulation MMP14 TNF 25162582 3002847 Regulation MMP14 TNF 25162582 3002918 Regulation MMP14 TNF 25162582 3002921 Regulation MMP14 TNF 25162582 3002935 Regulation MMP14 TNF 25162582 3002942 Regulation MMP14 TNF 25250141 1148985 Regulation MMP14 TNF 25457675 805862 Regulation MMP14 TNFSF10 24611063 911565 Regulation MMP14 TSPAN1 10491398 1250538 Regulation MMP14 WNT7A 24479426 131562 Regulation MMP15 AGR2 17129374 107528 Regulation MMP15 CAPN8 21501525 1505172 Regulation MMP15 EPHB2 21320340 258961 Regulation MMP15 EPHB2 21738525 922826 Regulation MMP15 MMP28 19375502 1731673 Regulation MMP15 PECAM1 12591918 1291213 Regulation MMP15 PLAT 23565108 935287 Regulation MMP15 PLAT 24303218 2003316 Regulation MMP15 PLAU 24189182 787891 Regulation MMP15 TFPI2 23905012 853474 Regulation MMP15 TGM2 24130925 204532 Regulation MMP15 TLR7 17129374 107522 Regulation MMP15 TNF 17118171 3096380 Regulation MMP15 TNF 18093301 300979 Regulation MMP15 TNF 18093301 300982 Regulation MMP15 TNF 18093301 300985 Regulation MMP15 TNF 18852869 1908438 Regulation MMP15 TNF 19889233 3097694 Regulation MMP15 TNF 21547259 1749203 Regulation MMP15 TNF 21912722 2223905 Regulation MMP15 TNF 23389627 1811866 Regulation MMP15 TNF 23750094 163635 Regulation MMP15 TNF 24144354 651713 Regulation MMP15 TNF 24926361 844527 Regulation MMP15 TNF 25250141 1148986 Regulation MMP15 TNFSF10 24611063 911576 Regulation MMP15 TSPAN1 10491398 1250560 Regulation MMP15 WNT7A 24479426 131564 Regulation MMP16 AGR2 17129374 107540 Regulation MMP16 CAPN8 21501525 1505186 Regulation MMP16 EPHB2 21320340 258980 Regulation MMP16 EPHB2 21738525 922827 Regulation MMP16 MMP28 19375502 1731674 Regulation MMP16 PECAM1 12591918 1291214 Regulation MMP16 PLAT 23565108 935288 Regulation MMP16 PLAT 24303218 2003317 Regulation MMP16 PLAU 24189182 787892 Regulation MMP16 TFPI2 23905012 853475 Regulation MMP16 TGM2 24130925 204533 Regulation MMP16 TLR7 17129374 107534 Regulation MMP16 TNF 17118171 3096381 Regulation MMP16 TNF 18852869 1908439 Regulation MMP16 TNF 19889233 3097695 Regulation MMP16 TNF 21547259 1749205 Regulation MMP16 TNF 21912722 2223906 Regulation MMP16 TNF 23389627 1811867 Regulation MMP16 TNF 23750094 163636 Regulation MMP16 TNF 24144354 651714 Regulation MMP16 TNF 24926361 844528 Regulation MMP16 TNF 25250141 1148987 Regulation MMP16 TNFSF10 24611063 911587 Regulation MMP16 TSPAN1 10491398 1250582 Regulation MMP16 WNT7A 24479426 131566 Regulation MMP17 AGR2 17129374 107552 Regulation MMP17 CAPN8 21501525 1505200 Regulation MMP17 EPHB2 21320340 258999 Regulation MMP17 EPHB2 21738525 922828 Regulation MMP17 MMP28 19375502 1731675 Regulation MMP17 PECAM1 12591918 1291215 Regulation MMP17 PLAT 23565108 935289 Regulation MMP17 PLAT 24303218 2003318 Regulation MMP17 PLAU 24189182 787893 Regulation MMP17 TFPI2 23905012 853476 Regulation MMP17 TGM2 24130925 204534 Regulation MMP17 TLR7 17129374 107546 Regulation MMP17 TNF 17118171 3096382 Regulation MMP17 TNF 18852869 1908440 Regulation MMP17 TNF 19889233 3097696 Regulation MMP17 TNF 21547259 1749207 Regulation MMP17 TNF 21912722 2223907 Regulation MMP17 TNF 23389627 1811868 Regulation MMP17 TNF 23750094 163637 Regulation MMP17 TNF 24144354 651715 Regulation MMP17 TNF 24926361 844529 Regulation MMP17 TNF 25250141 1148988 Regulation MMP17 TNFSF10 24611063 911598 Regulation MMP17 TSPAN1 10491398 1250604 Regulation MMP17 WNT7A 24479426 131568 Regulation MMP19 AGR2 17129374 107564 Regulation MMP19 CAPN8 21501525 1505214 Regulation MMP19 EPHB2 21320340 259018 Regulation MMP19 EPHB2 21738525 922829 Regulation MMP19 MMP28 19375502 1731676 Regulation MMP19 PECAM1 12591918 1291216 Regulation MMP19 PLAT 23565108 935290 Regulation MMP19 PLAT 24303218 2003319 Regulation MMP19 PLAU 24189182 787894 Regulation MMP19 TFPI2 23905012 853477 Regulation MMP19 TGM2 24130925 204535 Regulation MMP19 TLR7 17129374 107558 Regulation MMP19 TNF 17118171 3096383 Regulation MMP19 TNF 18852869 1908441 Regulation MMP19 TNF 19889233 3097697 Regulation MMP19 TNF 21547259 1749209 Regulation MMP19 TNF 21912722 2223908 Regulation MMP19 TNF 23389627 1811869 Regulation MMP19 TNF 23750094 163638 Regulation MMP19 TNF 24144354 651716 Regulation MMP19 TNF 24926361 844530 Regulation MMP19 TNF 25250141 1148989 Regulation MMP19 TNFSF10 24611063 911609 Regulation MMP19 TSPAN1 10491398 1250626 Regulation MMP19 WNT7A 24479426 131570 Regulation MMP2 ADAMTS1 19116037 3096835 Regulation MMP2 AGR2 17129374 107576 Regulation MMP2 ANGPT1 20805979 2471619 Regulation MMP2 AXIN2 24454854 2910174 Regulation MMP2 CAPN8 21501525 1505228 Regulation MMP2 CLU 22949882 1098131 Regulation MMP2 CTGF 25003330 2195011 Regulation MMP2 EPHB2 20214814 255478 Regulation MMP2 EPHB2 21320340 259037 Regulation MMP2 EPHB2 21320340 259180 Regulation MMP2 EPHB2 21738525 922830 Regulation MMP2 EPHB2 22506069 2618354 Regulation MMP2 EPHB2 24278338 2885775 Regulation MMP2 EPHB2 24278338 2885781 Regulation MMP2 EPHB2 24318272 2186042 Regulation MMP2 EPHB2 24348851 2167465 Regulation MMP2 EPHB2 24996644 1702298 Regulation MMP2 EPHB2 25203554 3006405 Regulation MMP2 FAS 21573233 2522998 Regulation MMP2 FOXO1 21965295 1795338 Regulation MMP2 ID1 23714001 1699826 Regulation MMP2 ID1 23714001 1699827 Regulation MMP2 MAP2K6 22310287 2146253 Regulation MMP2 MAP2K6 24013225 2153533 Regulation MMP2 MAP2K6 24318272 2186048 Regulation MMP2 MMP28 19375502 1731677 Regulation MMP2 MMP28 23967226 2835065 Regulation MMP2 MMP28 24978432 504551 Regulation MMP2 MMP7 23967226 2835080 Regulation MMP2 MMP7 24978432 504569 Regulation MMP2 NES 22870054 1920652 Regulation MMP2 NNMT 22545051 1673657 Regulation MMP2 NNMT 22545051 1673658 Regulation MMP2 NNMT 22545051 1673663 Regulation MMP2 PECAM1 12591918 1291217 Regulation MMP2 PLAT 23565108 935291 Regulation MMP2 PLAT 24303218 2003320 Regulation MMP2 PLAU 24189182 787895 Regulation MMP2 PLAU 25222667 1730979 Regulation MMP2 TFPI2 17717633 493682 Regulation MMP2 TFPI2 23905012 853478 Regulation MMP2 TGM2 24130925 204481 Regulation MMP2 TGM2 24130925 204482 Regulation MMP2 TGM2 24130925 204487 Regulation MMP2 TGM2 24130925 204497 Regulation MMP2 TGM2 24130925 204536 Regulation MMP2 TLR7 17129374 107570 Regulation MMP2 TNF 12966436 423289 Regulation MMP2 TNF 16106101 1740051 Regulation MMP2 TNF 16106101 1740052 Regulation MMP2 TNF 17118171 3096384 Regulation MMP2 TNF 18852869 1908442 Regulation MMP2 TNF 19281093 1071728 Regulation MMP2 TNF 19889233 3097698 Regulation MMP2 TNF 21547259 1749211 Regulation MMP2 TNF 21912722 2223909 Regulation MMP2 TNF 23389627 1811870 Regulation MMP2 TNF 23750094 163639 Regulation MMP2 TNF 24085323 1142171 Regulation MMP2 TNF 24085323 1142172 Regulation MMP2 TNF 24085323 1142173 Regulation MMP2 TNF 24085323 1142174 Regulation MMP2 TNF 24085323 1142175 Regulation MMP2 TNF 24085323 1142201 Regulation MMP2 TNF 24085323 1142202 Regulation MMP2 TNF 24085323 1142203 Regulation MMP2 TNF 24085323 1142204 Regulation MMP2 TNF 24144354 651717 Regulation MMP2 TNF 24190483 1142424 Regulation MMP2 TNF 24223987 2877531 Regulation MMP2 TNF 24502696 1233186 Regulation MMP2 TNF 24926361 844531 Regulation MMP2 TNF 25250141 1148990 Regulation MMP2 TNF 25457675 805860 Regulation MMP2 TNFSF10 16622457 427503 Regulation MMP2 TNFSF10 21209944 2492479 Regulation MMP2 TNFSF10 24611063 911620 Regulation MMP2 TSPAN1 10491398 1249735 Regulation MMP2 TSPAN1 10491398 1250648 Regulation MMP2 TSPAN1 10491398 1250870 Regulation MMP2 WIF1 20573255 1856528 Regulation MMP2 WNT7A 24479426 131572 Regulation MMP20 AGR2 17129374 107588 Regulation MMP20 CAPN8 21501525 1505242 Regulation MMP20 EPHB2 21320340 259056 Regulation MMP20 EPHB2 21738525 922831 Regulation MMP20 MMP28 19375502 1731678 Regulation MMP20 PECAM1 12591918 1291218 Regulation MMP20 PLAT 23565108 935292 Regulation MMP20 PLAT 24303218 2003321 Regulation MMP20 PLAU 24189182 787896 Regulation MMP20 TFPI2 23905012 853479 Regulation MMP20 TGM2 24130925 204537 Regulation MMP20 TLR7 17129374 107582 Regulation MMP20 TNF 17118171 3096385 Regulation MMP20 TNF 18852869 1908443 Regulation MMP20 TNF 19889233 3097699 Regulation MMP20 TNF 21547259 1749213 Regulation MMP20 TNF 21912722 2223910 Regulation MMP20 TNF 23389627 1811871 Regulation MMP20 TNF 23750094 163640 Regulation MMP20 TNF 24144354 651718 Regulation MMP20 TNF 24926361 844532 Regulation MMP20 TNF 25250141 1148991 Regulation MMP20 TNFSF10 24611063 911631 Regulation MMP20 TSPAN1 10491398 1250670 Regulation MMP20 WNT7A 24479426 131574 Regulation MMP21 AGR2 17129374 107432 Regulation MMP21 CAPN8 21501525 1505060 Regulation MMP21 EPHB2 21320340 258806 Regulation MMP21 EPHB2 21738525 922818 Regulation MMP21 MMP28 19375502 1731664 Regulation MMP21 PECAM1 12591918 1291205 Regulation MMP21 PLAT 23565108 935279 Regulation MMP21 PLAT 24303218 2003308 Regulation MMP21 PLAU 24189182 787883 Regulation MMP21 TFPI2 23905012 853466 Regulation MMP21 TGM2 24130925 204524 Regulation MMP21 TLR7 17129374 107426 Regulation MMP21 TNF 17118171 3096372 Regulation MMP21 TNF 18852869 1908430 Regulation MMP21 TNF 19889233 3097686 Regulation MMP21 TNF 21547259 1749187 Regulation MMP21 TNF 21912722 2223897 Regulation MMP21 TNF 23389627 1811858 Regulation MMP21 TNF 23750094 163627 Regulation MMP21 TNF 24144354 651705 Regulation MMP21 TNF 24926361 844516 Regulation MMP21 TNF 25250141 1148978 Regulation MMP21 TNFSF10 24611063 911488 Regulation MMP21 TSPAN1 10491398 1250384 Regulation MMP21 WNT7A 24479426 131545 Regulation MMP24 AGR2 17129374 107600 Regulation MMP24 CAPN8 21501525 1505256 Regulation MMP24 EPHB2 21320340 259075 Regulation MMP24 EPHB2 21738525 922832 Regulation MMP24 MMP28 19375502 1731679 Regulation MMP24 PECAM1 12591918 1291219 Regulation MMP24 PLAT 23565108 935293 Regulation MMP24 PLAT 24303218 2003322 Regulation MMP24 PLAU 24189182 787897 Regulation MMP24 TFPI2 23905012 853480 Regulation MMP24 TGM2 24130925 204538 Regulation MMP24 TLR7 17129374 107594 Regulation MMP24 TNF 17118171 3096386 Regulation MMP24 TNF 18852869 1908444 Regulation MMP24 TNF 19889233 3097700 Regulation MMP24 TNF 21067565 397475 Regulation MMP24 TNF 21547259 1749215 Regulation MMP24 TNF 21912722 2223911 Regulation MMP24 TNF 23389627 1811872 Regulation MMP24 TNF 23750094 163641 Regulation MMP24 TNF 24144354 651719 Regulation MMP24 TNF 24926361 844533 Regulation MMP24 TNF 25250141 1148992 Regulation MMP24 TNFSF10 24611063 911642 Regulation MMP24 TSPAN1 10491398 1250692 Regulation MMP24 WNT7A 24479426 131576 Regulation MMP25 AGR2 17129374 107396 Regulation MMP25 CAPN8 21501525 1505018 Regulation MMP25 EPHB2 21320340 258749 Regulation MMP25 EPHB2 21738525 922815 Regulation MMP25 MMP28 19375502 1731661 Regulation MMP25 PECAM1 12591918 1291202 Regulation MMP25 PLAT 23565108 935276 Regulation MMP25 PLAT 24303218 2003305 Regulation MMP25 PLAU 24189182 787880 Regulation MMP25 TFPI2 23905012 853463 Regulation MMP25 TGM2 24130925 204521 Regulation MMP25 TLR7 17129374 107390 Regulation MMP25 TNF 17118171 3096369 Regulation MMP25 TNF 18852869 1908427 Regulation MMP25 TNF 19889233 3097683 Regulation MMP25 TNF 21547259 1749181 Regulation MMP25 TNF 21912722 2223894 Regulation MMP25 TNF 23389627 1811855 Regulation MMP25 TNF 23750094 163624 Regulation MMP25 TNF 24144354 651702 Regulation MMP25 TNF 24926361 844513 Regulation MMP25 TNF 25250141 1148975 Regulation MMP25 TNFSF10 24611063 911455 Regulation MMP25 TSPAN1 10491398 1250318 Regulation MMP25 WNT7A 24479426 131539 Regulation MMP26 AGR2 17129374 107408 Regulation MMP26 CAPN8 21501525 1505032 Regulation MMP26 EPHB2 21320340 258768 Regulation MMP26 EPHB2 21738525 922816 Regulation MMP26 MMP28 19375502 1731662 Regulation MMP26 PECAM1 12591918 1291203 Regulation MMP26 PLAT 23565108 935277 Regulation MMP26 PLAT 24303218 2003306 Regulation MMP26 PLAU 24189182 787881 Regulation MMP26 TFPI2 23905012 853464 Regulation MMP26 TGM2 24130925 204522 Regulation MMP26 TLR7 17129374 107402 Regulation MMP26 TNF 17118171 3096370 Regulation MMP26 TNF 18852869 1908428 Regulation MMP26 TNF 19889233 3097684 Regulation MMP26 TNF 21547259 1749183 Regulation MMP26 TNF 21912722 2223895 Regulation MMP26 TNF 23389627 1811856 Regulation MMP26 TNF 23750094 163625 Regulation MMP26 TNF 24144354 651703 Regulation MMP26 TNF 24926361 844514 Regulation MMP26 TNF 25250141 1148976 Regulation MMP26 TNFSF10 24611063 911466 Regulation MMP26 TSPAN1 10491398 1250340 Regulation MMP26 WNT7A 24479426 131541 Regulation MMP27 AGR2 17129374 107420 Regulation MMP27 CAPN8 21501525 1505046 Regulation MMP27 EPHB2 21320340 258787 Regulation MMP27 EPHB2 21738525 922817 Regulation MMP27 MMP28 19375502 1731663 Regulation MMP27 PECAM1 12591918 1291204 Regulation MMP27 PLAT 23565108 935278 Regulation MMP27 PLAT 24303218 2003307 Regulation MMP27 PLAU 24189182 787882 Regulation MMP27 TFPI2 23905012 853465 Regulation MMP27 TGM2 24130925 204523 Regulation MMP27 TLR7 17129374 107414 Regulation MMP27 TNF 17118171 3096371 Regulation MMP27 TNF 18852869 1908429 Regulation MMP27 TNF 19889233 3097685 Regulation MMP27 TNF 21547259 1749185 Regulation MMP27 TNF 21912722 2223896 Regulation MMP27 TNF 23389627 1811857 Regulation MMP27 TNF 23750094 163626 Regulation MMP27 TNF 24144354 651704 Regulation MMP27 TNF 24926361 844515 Regulation MMP27 TNF 25250141 1148977 Regulation MMP27 TNFSF10 24611063 911477 Regulation MMP27 TSPAN1 10491398 1250362 Regulation MMP27 WNT7A 24479426 131543 Regulation MMP28 ACE 21887284 2549105 Regulation MMP28 ADIPOQ 19883500 117630 Regulation MMP28 AGR2 17129374 107444 Regulation MMP28 AGR3 17129374 107443 Regulation MMP28 AKT1 21320340 258826 Regulation MMP28 AKT1 25147440 1761539 Regulation MMP28 AKT2 21320340 258827 Regulation MMP28 AKT2 25147440 1761540 Regulation MMP28 AKT3 21320340 258828 Regulation MMP28 AKT3 25147440 1761541 Regulation MMP28 AP2M1 9683296 447419 Regulation MMP28 BAX 12756268 1527255 Regulation MMP28 BCL2 11181702 1518634 Regulation MMP28 BCL2 11181702 1518678 Regulation MMP28 BCL2 21083891 2231236 Regulation MMP28 BNIP3 22292033 2592061 Regulation MMP28 BRMS1 24879377 2975637 Regulation MMP28 BSG 16207318 104039 Regulation MMP28 BSG 16207318 104061 Regulation MMP28 BSG 16507143 105002 Regulation MMP28 BSG 16507143 105024 Regulation MMP28 BSG 19664212 116381 Regulation MMP28 BSG 25076423 2993189 Regulation MMP28 BSG 25076423 2993281 Regulation MMP28 BSG 25076423 2993282 Regulation MMP28 BSG 25076423 2993321 Regulation MMP28 BSG 25268615 1131376 Regulation MMP28 BSG 25268615 1131465 Regulation MMP28 BSG 25404518 133872 Regulation MMP28 C4BPA 22259633 1710509 Regulation MMP28 CA2 23233904 941674 Regulation MMP28 CAPN1 21501525 1505066 Regulation MMP28 CAPN10 21501525 1505067 Regulation MMP28 CAPN11 21501525 1505068 Regulation MMP28 CAPN12 21501525 1505065 Regulation MMP28 CAPN13 21501525 1505076 Regulation MMP28 CAPN14 21501525 1505077 Regulation MMP28 CAPN15 21501525 1505064 Regulation MMP28 CAPN2 21501525 1505069 Regulation MMP28 CAPN3 21501525 1505070 Regulation MMP28 CAPN5 21501525 1505071 Regulation MMP28 CAPN6 21501525 1505072 Regulation MMP28 CAPN7 21501525 1505073 Regulation MMP28 CAPN8 21501525 1505074 Regulation MMP28 CAPN9 21501525 1505075 Regulation MMP28 CASP1 19715609 1851677 Regulation MMP28 CASP1 24091661 567016 Regulation MMP28 CASP1 24260080 2166500 Regulation MMP28 CASP1 24260080 2166501 Regulation MMP28 CASP10 19715609 1851678 Regulation MMP28 CASP10 24091661 567017 Regulation MMP28 CASP10 24260080 2166502 Regulation MMP28 CASP10 24260080 2166503 Regulation MMP28 CASP12 19715609 1851688 Regulation MMP28 CASP12 24091661 567027 Regulation MMP28 CASP12 24260080 2166522 Regulation MMP28 CASP12 24260080 2166523 Regulation MMP28 CASP14 19715609 1851679 Regulation MMP28 CASP14 24091661 567018 Regulation MMP28 CASP14 24260080 2166504 Regulation MMP28 CASP14 24260080 2166505 Regulation MMP28 CASP16 19715609 1851689 Regulation MMP28 CASP16 24091661 567028 Regulation MMP28 CASP16 24260080 2166524 Regulation MMP28 CASP16 24260080 2166525 Regulation MMP28 CASP2 19715609 1851680 Regulation MMP28 CASP2 24091661 567019 Regulation MMP28 CASP2 24260080 2166506 Regulation MMP28 CASP2 24260080 2166507 Regulation MMP28 CASP2 24664279 2938220 Regulation MMP28 CASP3 19715609 1851681 Regulation MMP28 CASP3 24091661 567020 Regulation MMP28 CASP3 24260080 2166508 Regulation MMP28 CASP3 24260080 2166509 Regulation MMP28 CASP4 19715609 1851682 Regulation MMP28 CASP4 24091661 567021 Regulation MMP28 CASP4 24260080 2166510 Regulation MMP28 CASP4 24260080 2166511 Regulation MMP28 CASP5 19715609 1851683 Regulation MMP28 CASP5 24091661 567022 Regulation MMP28 CASP5 24260080 2166512 Regulation MMP28 CASP5 24260080 2166513 Regulation MMP28 CASP6 19715609 1851684 Regulation MMP28 CASP6 24091661 567023 Regulation MMP28 CASP6 24260080 2166514 Regulation MMP28 CASP6 24260080 2166515 Regulation MMP28 CASP7 19715609 1851685 Regulation MMP28 CASP7 24091661 567024 Regulation MMP28 CASP7 24260080 2166516 Regulation MMP28 CASP7 24260080 2166517 Regulation MMP28 CASP8 19715609 1851686 Regulation MMP28 CASP8 21569377 1658347 Regulation MMP28 CASP8 24091661 567025 Regulation MMP28 CASP8 24260080 2166518 Regulation MMP28 CASP8 24260080 2166519 Regulation MMP28 CASP9 19715609 1851687 Regulation MMP28 CASP9 24091661 567026 Regulation MMP28 CASP9 24260080 2166520 Regulation MMP28 CASP9 24260080 2166521 Regulation MMP28 CAT 21283566 2495625 Regulation MMP28 CAV1 18596970 2392398 Regulation MMP28 CCL25 20649989 3226133 Regulation MMP28 CCR7 19363519 7295 Regulation MMP28 CCR7 19363519 7408 Regulation MMP28 CCR7 19363519 7431 Regulation MMP28 CD2 18629305 793188 Regulation MMP28 CD9 23840773 2817497 Regulation MMP28 CD9 23840773 2817547 Regulation MMP28 CDK5 18385789 1907970 Regulation MMP28 CNGA1 22699690 621498 Regulation MMP28 CNGB1 22699690 621499 Regulation MMP28 CPOX 21371008 451314 Regulation MMP28 CRIP1 21731450 1091164 Regulation MMP28 CRIP2 21731450 1091165 Regulation MMP28 CRIP3 21731450 1091163 Regulation MMP28 CXCL12 21403844 506743 Regulation MMP28 CXCL13 20412587 1854090 Regulation MMP28 CXCL17 22454662 813824 Regulation MMP28 CYR61 25351421 1887045 Regulation MMP28 DKK3 23476112 3129259 Regulation MMP28 EARS2 24130267 91505 Regulation MMP28 ECM1 18670615 3074494 Regulation MMP28 ECM1 19298660 352738 Regulation MMP28 ECM1 23847438 1061490 Regulation MMP28 ECM1 25530657 738505 Regulation MMP28 ECM2 18670615 3074495 Regulation MMP28 ECM2 19298660 352739 Regulation MMP28 ECM2 23847438 1061491 Regulation MMP28 ECM2 25530657 738506 Regulation MMP28 EGF 15083203 424456 Regulation MMP28 EGF 24098477 2856573 Regulation MMP28 EGF 8471429 444978 Regulation MMP28 EGF 8471429 444979 Regulation MMP28 EGFR 24362507 502592 Regulation MMP28 EPHB2 21320340 258825 Regulation MMP28 EPHB2 21738525 922819 Regulation MMP28 ERVK-6 24455428 3151102 Regulation MMP28 ETS1 22971289 472191 Regulation MMP28 ETS1 24281073 501579 Regulation MMP28 ETS1 25210488 1488704 Regulation MMP28 ETS2 24281073 501580 Regulation MMP28 ETS2 25210488 1488705 Regulation MMP28 ETV1 21673681 436908 Regulation MMP28 EZH2 22272343 2589679 Regulation MMP28 EZH2 22272343 2589680 Regulation MMP28 FASLG 24611063 911507 Regulation MMP28 FGF2 10684258 1256005 Regulation MMP28 FURIN 19375502 1731666 Regulation MMP28 FURIN 21152186 154470 Regulation MMP28 FURIN 23936445 2830495 Regulation MMP28 GLRX 18560520 2390946 Regulation MMP28 GLRX 18560520 2390990 Regulation MMP28 GLRX 18560520 2391078 Regulation MMP28 HDAC1 15899037 103292 Regulation MMP28 HDAC1 24062615 1628733 Regulation MMP28 HDAC2 15899037 103293 Regulation MMP28 HDAC2 24062615 1628734 Regulation MMP28 HGF 10851027 1259188 Regulation MMP28 HGF 11027427 417885 Regulation MMP28 HMGB1 20799933 119835 Regulation MMP28 HMGB1 20799933 119836 Regulation MMP28 HMGB1 20799933 119837 Regulation MMP28 HPSE 19360105 2412785 Regulation MMP28 HPSE 22590508 2640742 Regulation MMP28 HRASLS 23687991 1232124 Regulation MMP28 IDO1 11375052 224790 Regulation MMP28 IFI44 20109185 284165 Regulation MMP28 IGF1 24717414 1703657 Regulation MMP28 IGF1R 23061721 533144 Regulation MMP28 IL11 25352758 1716765 Regulation MMP28 IL13 15743487 102614 Regulation MMP28 IL13 15743487 102636 Regulation MMP28 IL17A 19014637 463232 Regulation MMP28 IL17A 19627579 116133 Regulation MMP28 IL17A 19627579 116185 Regulation MMP28 IL17A 19627579 116214 Regulation MMP28 IL1A 11714393 98485 Regulation MMP28 IL1A 19695094 116607 Regulation MMP28 IL1A 20799933 119838 Regulation MMP28 IL1A 20799933 119839 Regulation MMP28 IL1A 20799933 119840 Regulation MMP28 IL1A 21801383 1652106 Regulation MMP28 IL1A 22011328 660041 Regulation MMP28 IL1A 22710193 2253047 Regulation MMP28 IL1A 23965253 129073 Regulation MMP28 IL1RN 17760968 108867 Regulation MMP28 IL1RN 17760968 108868 Regulation MMP28 INSR 23061721 533145 Regulation MMP28 JUN 14979937 100211 Regulation MMP28 JUN 17559674 108357 Regulation MMP28 JUN 18226189 110094 Regulation MMP28 JUN 20964825 855164 Regulation MMP28 JUN 23226337 2724210 Regulation MMP28 JUN 24281073 501581 Regulation MMP28 JUN 24349175 2896974 Regulation MMP28 LPA 21876704 3172827 Regulation MMP28 LTB 12516548 2001388 Regulation MMP28 LXN 21762534 260548 Regulation MMP28 MAPK1 16906368 1769314 Regulation MMP28 MAPK1 19765281 116853 Regulation MMP28 MAPK1 21320340 258829 Regulation MMP28 MAPK1 21371008 451077 Regulation MMP28 MAPK1 23587438 1666251 Regulation MMP28 MAPK1 23760725 2164143 Regulation MMP28 MAPK1 23760725 2164144 Regulation MMP28 MAPK1 23760725 2164145 Regulation MMP28 MAPK1 24204703 2873853 Regulation MMP28 MAPK1 24466137 2913423 Regulation MMP28 MAPK1 24664279 2938222 Regulation MMP28 MAPK1 25205985 90268 Regulation MMP28 MAPK10 16906368 1769315 Regulation MMP28 MAPK10 19765281 116854 Regulation MMP28 MAPK10 21320340 258830 Regulation MMP28 MAPK10 21371008 451078 Regulation MMP28 MAPK10 23587438 1666252 Regulation MMP28 MAPK10 23760725 2164146 Regulation MMP28 MAPK10 23760725 2164147 Regulation MMP28 MAPK10 23760725 2164148 Regulation MMP28 MAPK10 24204703 2873854 Regulation MMP28 MAPK10 24466137 2913424 Regulation MMP28 MAPK10 24664279 2938223 Regulation MMP28 MAPK10 25205985 90269 Regulation MMP28 MAPK11 16906368 1769316 Regulation MMP28 MAPK11 19765281 116855 Regulation MMP28 MAPK11 21320340 258831 Regulation MMP28 MAPK11 21371008 451079 Regulation MMP28 MAPK11 23587438 1666253 Regulation MMP28 MAPK11 23760725 2164149 Regulation MMP28 MAPK11 23760725 2164150 Regulation MMP28 MAPK11 23760725 2164151 Regulation MMP28 MAPK11 24204703 2873855 Regulation MMP28 MAPK11 24466137 2913425 Regulation MMP28 MAPK11 24664279 2938224 Regulation MMP28 MAPK11 25205985 90270 Regulation MMP28 MAPK12 16906368 1769317 Regulation MMP28 MAPK12 19765281 116856 Regulation MMP28 MAPK12 21320340 258832 Regulation MMP28 MAPK12 21371008 451080 Regulation MMP28 MAPK12 23587438 1666254 Regulation MMP28 MAPK12 23760725 2164152 Regulation MMP28 MAPK12 23760725 2164153 Regulation MMP28 MAPK12 23760725 2164154 Regulation MMP28 MAPK12 24204703 2873856 Regulation MMP28 MAPK12 24466137 2913426 Regulation MMP28 MAPK12 24664279 2938225 Regulation MMP28 MAPK12 25205985 90271 Regulation MMP28 MAPK13 16906368 1769318 Regulation MMP28 MAPK13 19765281 116857 Regulation MMP28 MAPK13 21320340 258833 Regulation MMP28 MAPK13 21371008 451081 Regulation MMP28 MAPK13 23587438 1666255 Regulation MMP28 MAPK13 23760725 2164155 Regulation MMP28 MAPK13 23760725 2164156 Regulation MMP28 MAPK13 23760725 2164157 Regulation MMP28 MAPK13 24204703 2873857 Regulation MMP28 MAPK13 24466137 2913427 Regulation MMP28 MAPK13 24664279 2938226 Regulation MMP28 MAPK13 25205985 90272 Regulation MMP28 MAPK14 16906368 1769319 Regulation MMP28 MAPK14 19765281 116858 Regulation MMP28 MAPK14 21320340 258834 Regulation MMP28 MAPK14 21371008 451082 Regulation MMP28 MAPK14 23587438 1666256 Regulation MMP28 MAPK14 23760725 2164158 Regulation MMP28 MAPK14 23760725 2164159 Regulation MMP28 MAPK14 23760725 2164160 Regulation MMP28 MAPK14 24204703 2873858 Regulation MMP28 MAPK14 24466137 2913428 Regulation MMP28 MAPK14 24664279 2938227 Regulation MMP28 MAPK14 25205985 90273 Regulation MMP28 MAPK15 16906368 1769313 Regulation MMP28 MAPK15 19765281 116852 Regulation MMP28 MAPK15 21320340 258824 Regulation MMP28 MAPK15 21371008 451076 Regulation MMP28 MAPK15 23587438 1666250 Regulation MMP28 MAPK15 23760725 2164140 Regulation MMP28 MAPK15 23760725 2164141 Regulation MMP28 MAPK15 23760725 2164142 Regulation MMP28 MAPK15 24204703 2873852 Regulation MMP28 MAPK15 24466137 2913422 Regulation MMP28 MAPK15 24664279 2938221 Regulation MMP28 MAPK15 25205985 90267 Regulation MMP28 MAPK3 16906368 1769320 Regulation MMP28 MAPK3 19765281 116859 Regulation MMP28 MAPK3 21320340 258835 Regulation MMP28 MAPK3 21371008 451083 Regulation MMP28 MAPK3 23587438 1666257 Regulation MMP28 MAPK3 23760725 2164161 Regulation MMP28 MAPK3 23760725 2164162 Regulation MMP28 MAPK3 23760725 2164163 Regulation MMP28 MAPK3 24204703 2873859 Regulation MMP28 MAPK3 24466137 2913429 Regulation MMP28 MAPK3 24664279 2938228 Regulation MMP28 MAPK3 25205985 90274 Regulation MMP28 MAPK4 16906368 1769321 Regulation MMP28 MAPK4 19765281 116860 Regulation MMP28 MAPK4 21320340 258836 Regulation MMP28 MAPK4 21371008 451084 Regulation MMP28 MAPK4 23587438 1666258 Regulation MMP28 MAPK4 23760725 2164164 Regulation MMP28 MAPK4 23760725 2164165 Regulation MMP28 MAPK4 23760725 2164166 Regulation MMP28 MAPK4 24204703 2873860 Regulation MMP28 MAPK4 24466137 2913430 Regulation MMP28 MAPK4 24664279 2938229 Regulation MMP28 MAPK4 25205985 90275 Regulation MMP28 MAPK6 16906368 1769322 Regulation MMP28 MAPK6 19765281 116861 Regulation MMP28 MAPK6 21320340 258837 Regulation MMP28 MAPK6 21371008 451085 Regulation MMP28 MAPK6 23587438 1666259 Regulation MMP28 MAPK6 23760725 2164167 Regulation MMP28 MAPK6 23760725 2164168 Regulation MMP28 MAPK6 23760725 2164169 Regulation MMP28 MAPK6 24204703 2873861 Regulation MMP28 MAPK6 24466137 2913431 Regulation MMP28 MAPK6 24664279 2938230 Regulation MMP28 MAPK6 25205985 90276 Regulation MMP28 MAPK7 16906368 1769323 Regulation MMP28 MAPK7 19765281 116862 Regulation MMP28 MAPK7 21320340 258838 Regulation MMP28 MAPK7 21371008 451086 Regulation MMP28 MAPK7 23587438 1666260 Regulation MMP28 MAPK7 23760725 2164170 Regulation MMP28 MAPK7 23760725 2164171 Regulation MMP28 MAPK7 23760725 2164172 Regulation MMP28 MAPK7 24204703 2873862 Regulation MMP28 MAPK7 24466137 2913432 Regulation MMP28 MAPK7 24664279 2938231 Regulation MMP28 MAPK7 25205985 90277 Regulation MMP28 MAPK8 16906368 1769324 Regulation MMP28 MAPK8 19765281 116863 Regulation MMP28 MAPK8 21320340 258839 Regulation MMP28 MAPK8 21371008 451087 Regulation MMP28 MAPK8 23028407 2219714 Regulation MMP28 MAPK8 23587438 1666261 Regulation MMP28 MAPK8 23760725 2164173 Regulation MMP28 MAPK8 23760725 2164174 Regulation MMP28 MAPK8 23760725 2164175 Regulation MMP28 MAPK8 24204703 2873863 Regulation MMP28 MAPK8 24466137 2913433 Regulation MMP28 MAPK8 24664279 2938232 Regulation MMP28 MAPK8 25205985 90278 Regulation MMP28 MAPK9 16906368 1769325 Regulation MMP28 MAPK9 19765281 116864 Regulation MMP28 MAPK9 21320340 258840 Regulation MMP28 MAPK9 21371008 451088 Regulation MMP28 MAPK9 23587438 1666262 Regulation MMP28 MAPK9 23760725 2164176 Regulation MMP28 MAPK9 23760725 2164177 Regulation MMP28 MAPK9 23760725 2164178 Regulation MMP28 MAPK9 24204703 2873864 Regulation MMP28 MAPK9 24466137 2913434 Regulation MMP28 MAPK9 24664279 2938233 Regulation MMP28 MAPK9 25205985 90279 Regulation MMP28 MBTPS1 16636149 1329328 Regulation MMP28 MIF 16872482 106370 Regulation MMP28 MIF 23050964 89499 Regulation MMP28 MIF 24069610 184269 Regulation MMP28 MMP14 18762577 1356231 Regulation MMP28 MMP28 19375502 1731665 Regulation MMP28 MOK 18511846 706161 Regulation MMP28 MPO 12615902 1526084 Regulation MMP28 MPO 21547259 1749190 Regulation MMP28 MPO 22723783 958083 Regulation MMP28 MRC1 23937653 380389 Regulation MMP28 MRC2 23937653 380388 Regulation MMP28 MSC 24692869 1691208 Regulation MMP28 MSLN 23694968 3135961 Regulation MMP28 MTOR 23383143 2748323 Regulation MMP28 MTOR PMC4212306 3206440 Regulation MMP28 MTOR PMC4212306 3206559 Regulation MMP28 MYLIP 20023698 2128578 Regulation MMP28 MYLIP 23857777 781450 Regulation MMP28 MYOF 22761893 2659085 Regulation MMP28 MYOF 22761893 2659108 Regulation MMP28 NA 21118526 2111654 Regulation MMP28 NA 21192843 623476 Regulation MMP28 NA 21283566 2495626 Regulation MMP28 NA 21998720 2562204 Regulation MMP28 NA 23760725 2164179 Regulation MMP28 NA 23760725 2164180 Regulation MMP28 NA 23760725 2164181 Regulation MMP28 NA 24091661 567254 Regulation MMP28 NA 24260080 2166526 Regulation MMP28 NA 24260080 2166527 Regulation MMP28 NA 24260080 2166528 Regulation MMP28 NFKB1 23226337 2724211 Regulation MMP28 NFKB1 PMC3405422 805089 Regulation MMP28 NOS3 22936987 2682601 Regulation MMP28 NOS3 24992254 2986385 Regulation MMP28 NOTCH1 24749110 1022529 Regulation MMP28 NOTCH2 24749110 1022530 Regulation MMP28 NOTCH3 24749110 1022531 Regulation MMP28 NOTCH4 24749110 1022532 Regulation MMP28 NOV 22353423 1661094 Regulation MMP28 NOV 22353423 1661145 Regulation MMP28 NOX1 23840100 1753723 Regulation MMP28 NOX3 23840100 1753724 Regulation MMP28 NOX4 23840100 1753725 Regulation MMP28 NOX5 23840100 1753722 Regulation MMP28 NPS 23940521 2831314 Regulation MMP28 NUP43 20109185 284166 Regulation MMP28 OSM 25057495 195482 Regulation MMP28 PARK7 20186336 2441656 Regulation MMP28 PECAM1 12591918 1291206 Regulation MMP28 PF4 22275902 956289 Regulation MMP28 PGD 23687991 1232125 Regulation MMP28 PI3 20459645 1854843 Regulation MMP28 PIK3CA 19775453 254178 Regulation MMP28 PIK3CA 21320340 258841 Regulation MMP28 PIK3CA 21799931 2539328 Regulation MMP28 PIK3CA 23383143 2748324 Regulation MMP28 PIK3CA 25147440 1761542 Regulation MMP28 PIK3R1 19775453 254179 Regulation MMP28 PIK3R1 21320340 258842 Regulation MMP28 PIK3R1 21799931 2539329 Regulation MMP28 PIK3R1 23383143 2748325 Regulation MMP28 PIK3R1 25147440 1761543 Regulation MMP28 PIP 19765281 116865 Regulation MMP28 PIP 19765281 117125 Regulation MMP28 PLAT 23565108 935280 Regulation MMP28 PLAT 24303218 2003309 Regulation MMP28 PLAU 24189182 787884 Regulation MMP28 PPARA PMC2756345 496226 Regulation MMP28 PRKAA1 23561047 509651 Regulation MMP28 PRKAA2 23561047 509652 Regulation MMP28 PRKAB1 23561047 509653 Regulation MMP28 PRKAB2 23561047 509654 Regulation MMP28 PRKAG1 23561047 509655 Regulation MMP28 PRKAG2 23561047 509656 Regulation MMP28 PRKD1 23562655 829774 Regulation MMP28 PROS1 18516228 3041311 Regulation MMP28 PTGS2 16831226 249494 Regulation MMP28 PTGS2 20169190 3046306 Regulation MMP28 PTGS2 21457581 3178066 Regulation MMP28 PTGS2 23552603 2156208 Regulation MMP28 PTGS2 23552603 2156273 Regulation MMP28 PTPRC 18779349 1551972 Regulation MMP28 QSOX1 23098186 472582 Regulation MMP28 RASGRF1 19678938 116454 Regulation MMP28 RBBP4 15899037 103294 Regulation MMP28 RBBP4 24062615 1628735 Regulation MMP28 RBBP7 15899037 103295 Regulation MMP28 RBBP7 24062615 1628736 Regulation MMP28 RBPJ 24971735 612531 Regulation MMP28 RELA 23226337 2724212 Regulation MMP28 RELA PMC3405422 805090 Regulation MMP28 RLN1 15642129 102015 Regulation MMP28 RLN1 16784544 106065 Regulation MMP28 RLN1 22936987 2682349 Regulation MMP28 RLN1 22936987 2682350 Regulation MMP28 RLN1 22936987 2682351 Regulation MMP28 RLN2 15642129 102016 Regulation MMP28 RLN2 16784544 106066 Regulation MMP28 RLN2 22936987 2682352 Regulation MMP28 RLN2 22936987 2682353 Regulation MMP28 RLN2 22936987 2682354 Regulation MMP28 RLN3 15642129 102017 Regulation MMP28 RLN3 16784544 106067 Regulation MMP28 RLN3 22936987 2682355 Regulation MMP28 RLN3 22936987 2682356 Regulation MMP28 RLN3 22936987 2682357 Regulation MMP28 S100A4 23922901 2827444 Regulation MMP28 SERPINF1 22690122 1224357 Regulation MMP28 SETD2 21847402 1238204 Regulation MMP28 SFN 23072510 127004 Regulation MMP28 SIRT1 20920189 3110980 Regulation MMP28 SOCS1 24238405 129986 Regulation MMP28 SP1 24755270 272823 Regulation MMP28 SPP1 16128620 2368449 Regulation MMP28 SRC 20167811 2007820 Regulation MMP28 SSFA2 7537277 1436603 Regulation MMP28 SULF2 22410125 471333 Regulation MMP28 SYT1 24755270 272824 Regulation MMP28 TAGLN 25050546 2990986 Regulation MMP28 TCF12 25029110 2989759 Regulation MMP28 TCF15 25029110 2989760 Regulation MMP28 TCF19 25029110 2989761 Regulation MMP28 TCF20 25029110 2989762 Regulation MMP28 TCF21 25029110 2989763 Regulation MMP28 TCF23 25029110 2989767 Regulation MMP28 TCF24 25029110 2989769 Regulation MMP28 TCF25 25029110 2989768 Regulation MMP28 TCF3 25029110 2989764 Regulation MMP28 TCF4 25029110 2989765 Regulation MMP28 TCF7 25029110 2989766 Regulation MMP28 TCF7L2 23965253 129587 Regulation MMP28 TERT 24388106 222502 Regulation MMP28 TET1 23533523 818066 Regulation MMP28 TET2 23533523 818064 Regulation MMP28 TET3 23533523 818065 Regulation MMP28 TFPI2 23905012 853467 Regulation MMP28 TGFB1 PMC3405422 805088 Regulation MMP28 TGFB1I1 24811612 1159574 Regulation MMP28 TGM2 24130925 204525 Regulation MMP28 THBS1 23749112 1107560 Regulation MMP28 TIMP1 20011114 3045815 Regulation MMP28 TIMP1 20011518 2433264 Regulation MMP28 TIMP1 21711826 519358 Regulation MMP28 TIMP1 21814555 2539835 Regulation MMP28 TIMP1 22701711 2652133 Regulation MMP28 TIMP1 22911824 2676998 Regulation MMP28 TIMP1 23029478 2698376 Regulation MMP28 TIMP1 23187000 219754 Regulation MMP28 TIMP1 24454910 2910359 Regulation MMP28 TIMP1 25076423 2993343 Regulation MMP28 TIMP2 21811685 1681573 Regulation MMP28 TIMP2 22911824 2676999 Regulation MMP28 TIMP2 23631818 3091893 Regulation MMP28 TLR1 17129374 107433 Regulation MMP28 TLR10 17129374 107441 Regulation MMP28 TLR2 17129374 107434 Regulation MMP28 TLR3 17129374 107435 Regulation MMP28 TLR4 17129374 107436 Regulation MMP28 TLR5 17129374 107437 Regulation MMP28 TLR6 17129374 107442 Regulation MMP28 TLR7 17129374 107438 Regulation MMP28 TLR8 17129374 107439 Regulation MMP28 TLR9 17129374 107440 Regulation MMP28 TLR9 24959259 2168880 Regulation MMP28 TLR9 24959259 2168881 Regulation MMP28 TNC 21818551 600169 Regulation MMP28 TNF 17118171 3096373 Regulation MMP28 TNF 18852869 1908431 Regulation MMP28 TNF 19889233 3097687 Regulation MMP28 TNF 21547259 1749189 Regulation MMP28 TNF 21801383 1652105 Regulation MMP28 TNF 21912722 2223898 Regulation MMP28 TNF 23389627 1811859 Regulation MMP28 TNF 23750094 163628 Regulation MMP28 TNF 24144354 651706 Regulation MMP28 TNF 24926361 844517 Regulation MMP28 TNF 25250141 1148979 Regulation MMP28 TNFSF10 24611063 911499 Regulation MMP28 TNFSF11 24611063 911500 Regulation MMP28 TNFSF12 24611063 911501 Regulation MMP28 TNFSF13 23383143 2748322 Regulation MMP28 TNFSF13 24611063 911502 Regulation MMP28 TNFSF14 24611063 911503 Regulation MMP28 TNFSF15 24611063 911504 Regulation MMP28 TNFSF18 24611063 911505 Regulation MMP28 TNFSF4 24611063 911506 Regulation MMP28 TNFSF8 24611063 911508 Regulation MMP28 TNFSF9 24611063 911509 Regulation MMP28 TSPAN1 10491398 1250406 Regulation MMP28 TSPAN10 10491398 1250415 Regulation MMP28 TSPAN11 10491398 1250417 Regulation MMP28 TSPAN12 10491398 1250410 Regulation MMP28 TSPAN13 10491398 1250411 Regulation MMP28 TSPAN14 10491398 1250413 Regulation MMP28 TSPAN15 10491398 1250412 Regulation MMP28 TSPAN16 10491398 1250416 Regulation MMP28 TSPAN17 10491398 1250403 Regulation MMP28 TSPAN18 10491398 1250408 Regulation MMP28 TSPAN19 10491398 1250418 Regulation MMP28 TSPAN2 10491398 1250407 Regulation MMP28 TSPAN3 10491398 1250404 Regulation MMP28 TSPAN31 10491398 1250397 Regulation MMP28 TSPAN32 10491398 1250402 Regulation MMP28 TSPAN33 10491398 1250414 Regulation MMP28 TSPAN4 10491398 1250401 Regulation MMP28 TSPAN5 10491398 1250405 Regulation MMP28 TSPAN6 10491398 1250400 Regulation MMP28 TSPAN7 10491398 1250398 Regulation MMP28 TSPAN8 10491398 1250399 Regulation MMP28 TSPAN9 10491398 1250409 Regulation MMP28 UCP2 17472436 2262931 Regulation MMP28 VEGFA 21193734 717007 Regulation MMP28 WISP2 14636425 523468 Regulation MMP28 WNT1 16438732 3106273 Regulation MMP28 WNT1 23071438 3059758 Regulation MMP28 WNT1 23965253 129303 Regulation MMP28 WNT11 16438732 3106274 Regulation MMP28 WNT11 23071438 3059759 Regulation MMP28 WNT11 23965253 129304 Regulation MMP28 WNT16 16438732 3106279 Regulation MMP28 WNT16 23071438 3059764 Regulation MMP28 WNT16 23965253 129309 Regulation MMP28 WNT2 16438732 3106275 Regulation MMP28 WNT2 23071438 3059760 Regulation MMP28 WNT2 23965253 129305 Regulation MMP28 WNT3 16438732 3106276 Regulation MMP28 WNT3 23071438 3059761 Regulation MMP28 WNT3 23965253 129306 Regulation MMP28 WNT3A 24479426 131548 Regulation MMP28 WNT4 16438732 3106277 Regulation MMP28 WNT4 23071438 3059762 Regulation MMP28 WNT4 23965253 129307 Regulation MMP28 WNT5A 24757147 135797 Regulation MMP28 WNT6 16438732 3106278 Regulation MMP28 WNT6 23071438 3059763 Regulation MMP28 WNT6 23965253 129308 Regulation MMP28 WNT7A 24479426 131547 Regulation MMP3 AGR2 17129374 107612 Regulation MMP3 CAPN8 21501525 1505270 Regulation MMP3 CTGF 25003330 2195012 Regulation MMP3 EPHB2 21320340 259094 Regulation MMP3 EPHB2 21738525 922833 Regulation MMP3 EPHB2 22114952 1229910 Regulation MMP3 MMP28 19375502 1731680 Regulation MMP3 PECAM1 12591918 1291220 Regulation MMP3 PLAT 23565108 935294 Regulation MMP3 PLAT 24303218 2003323 Regulation MMP3 PLAU 24189182 787898 Regulation MMP3 TFPI2 23905012 853481 Regulation MMP3 TGM2 24130925 204539 Regulation MMP3 TLR7 17129374 107606 Regulation MMP3 TNF 17118171 3096387 Regulation MMP3 TNF 18852869 1908445 Regulation MMP3 TNF 19889233 3097701 Regulation MMP3 TNF 19906289 117780 Regulation MMP3 TNF 19906289 117781 Regulation MMP3 TNF 21547259 1749217 Regulation MMP3 TNF 21912722 2223912 Regulation MMP3 TNF 23389627 1811873 Regulation MMP3 TNF 23750094 163642 Regulation MMP3 TNF 24062615 1628903 Regulation MMP3 TNF 24144354 651720 Regulation MMP3 TNF 24926361 844534 Regulation MMP3 TNF 25250141 1148993 Regulation MMP3 TNFSF10 24611063 911653 Regulation MMP3 TSPAN1 10491398 1250714 Regulation MMP3 WNT7A 24479426 131578 Regulation MMP7 ACE 21887284 2549120 Regulation MMP7 ADAM10 18478055 2388502 Regulation MMP7 ADIPOQ 19883500 117645 Regulation MMP7 AGR2 17129374 107624 Regulation MMP7 AGR3 17129374 107623 Regulation MMP7 AKT1 21320340 259114 Regulation MMP7 AKT1 25147440 1761619 Regulation MMP7 AKT2 21320340 259115 Regulation MMP7 AKT2 25147440 1761620 Regulation MMP7 AKT3 21320340 259116 Regulation MMP7 AKT3 25147440 1761621 Regulation MMP7 AP2M1 9683296 447456 Regulation MMP7 ASCL1 23300791 2735976 Regulation MMP7 BAX 12756268 1527270 Regulation MMP7 BCL2 11181702 1518649 Regulation MMP7 BCL2 11181702 1518693 Regulation MMP7 BCL2 21083891 2231251 Regulation MMP7 BNIP3 22292033 2592076 Regulation MMP7 BRMS1 24879377 2975652 Regulation MMP7 BSG 16207318 104054 Regulation MMP7 BSG 16207318 104076 Regulation MMP7 BSG 16507143 105017 Regulation MMP7 BSG 16507143 105039 Regulation MMP7 BSG 19664212 116396 Regulation MMP7 BSG 25076423 2993204 Regulation MMP7 BSG 25076423 2993311 Regulation MMP7 BSG 25076423 2993312 Regulation MMP7 BSG 25076423 2993336 Regulation MMP7 BSG 25268615 1131392 Regulation MMP7 BSG 25268615 1131480 Regulation MMP7 BSG 25404518 133888 Regulation MMP7 C4BPA 22259633 1710524 Regulation MMP7 CA2 23233904 941689 Regulation MMP7 CAPN1 21501525 1505276 Regulation MMP7 CAPN10 21501525 1505277 Regulation MMP7 CAPN11 21501525 1505278 Regulation MMP7 CAPN12 21501525 1505275 Regulation MMP7 CAPN13 21501525 1505286 Regulation MMP7 CAPN14 21501525 1505287 Regulation MMP7 CAPN15 21501525 1505274 Regulation MMP7 CAPN2 21501525 1505279 Regulation MMP7 CAPN3 21501525 1505280 Regulation MMP7 CAPN5 21501525 1505281 Regulation MMP7 CAPN6 21501525 1505282 Regulation MMP7 CAPN7 21501525 1505283 Regulation MMP7 CAPN8 21501525 1505284 Regulation MMP7 CAPN9 21501525 1505285 Regulation MMP7 CASP1 19715609 1851872 Regulation MMP7 CASP1 24091661 567211 Regulation MMP7 CASP1 24260080 2166935 Regulation MMP7 CASP1 24260080 2166936 Regulation MMP7 CASP10 19715609 1851873 Regulation MMP7 CASP10 24091661 567212 Regulation MMP7 CASP10 24260080 2166937 Regulation MMP7 CASP10 24260080 2166938 Regulation MMP7 CASP12 19715609 1851883 Regulation MMP7 CASP12 24091661 567222 Regulation MMP7 CASP12 24260080 2166957 Regulation MMP7 CASP12 24260080 2166958 Regulation MMP7 CASP14 19715609 1851874 Regulation MMP7 CASP14 24091661 567213 Regulation MMP7 CASP14 24260080 2166939 Regulation MMP7 CASP14 24260080 2166940 Regulation MMP7 CASP16 19715609 1851884 Regulation MMP7 CASP16 24091661 567223 Regulation MMP7 CASP16 24260080 2166959 Regulation MMP7 CASP16 24260080 2166960 Regulation MMP7 CASP2 19715609 1851875 Regulation MMP7 CASP2 24091661 567214 Regulation MMP7 CASP2 24260080 2166941 Regulation MMP7 CASP2 24260080 2166942 Regulation MMP7 CASP2 24664279 2938430 Regulation MMP7 CASP3 19715609 1851876 Regulation MMP7 CASP3 24091661 567215 Regulation MMP7 CASP3 24260080 2166943 Regulation MMP7 CASP3 24260080 2166944 Regulation MMP7 CASP4 19715609 1851877 Regulation MMP7 CASP4 24091661 567216 Regulation MMP7 CASP4 24260080 2166945 Regulation MMP7 CASP4 24260080 2166946 Regulation MMP7 CASP5 19715609 1851878 Regulation MMP7 CASP5 24091661 567217 Regulation MMP7 CASP5 24260080 2166947 Regulation MMP7 CASP5 24260080 2166948 Regulation MMP7 CASP6 19715609 1851879 Regulation MMP7 CASP6 24091661 567218 Regulation MMP7 CASP6 24260080 2166949 Regulation MMP7 CASP6 24260080 2166950 Regulation MMP7 CASP7 19715609 1851880 Regulation MMP7 CASP7 24091661 567219 Regulation MMP7 CASP7 24260080 2166951 Regulation MMP7 CASP7 24260080 2166952 Regulation MMP7 CASP8 19715609 1851881 Regulation MMP7 CASP8 21569377 1658363 Regulation MMP7 CASP8 24091661 567220 Regulation MMP7 CASP8 24260080 2166953 Regulation MMP7 CASP8 24260080 2166954 Regulation MMP7 CASP9 19715609 1851882 Regulation MMP7 CASP9 24091661 567221 Regulation MMP7 CASP9 24260080 2166955 Regulation MMP7 CASP9 24260080 2166956 Regulation MMP7 CAT 21283566 2495655 Regulation MMP7 CAV1 18596970 2392413 Regulation MMP7 CCL25 20649989 3226148 Regulation MMP7 CCR7 19363519 7310 Regulation MMP7 CCR7 19363519 7423 Regulation MMP7 CCR7 19363519 7446 Regulation MMP7 CD2 18629305 793218 Regulation MMP7 CD9 23840773 2817512 Regulation MMP7 CD9 23840773 2817562 Regulation MMP7 CDK5 18385789 1907986 Regulation MMP7 CNGA1 22699690 621528 Regulation MMP7 CNGB1 22699690 621529 Regulation MMP7 CPOX 21371008 451329 Regulation MMP7 CRIP1 21731450 1091209 Regulation MMP7 CRIP2 21731450 1091210 Regulation MMP7 CRIP3 21731450 1091208 Regulation MMP7 CXCL12 21403844 506758 Regulation MMP7 CXCL13 20412587 1854107 Regulation MMP7 CXCL17 22454662 813839 Regulation MMP7 CYCSP3 21423639 812402 Regulation MMP7 CYR61 25351421 1887060 Regulation MMP7 DKK1 24325363 1870470 Regulation MMP7 DKK1 24325363 1870472 Regulation MMP7 DKK3 23476112 3129274 Regulation MMP7 EARS2 24130267 91520 Regulation MMP7 ECM1 18670615 3074524 Regulation MMP7 ECM1 19298660 352768 Regulation MMP7 ECM1 23847438 1061520 Regulation MMP7 ECM1 25530657 738579 Regulation MMP7 ECM2 18670615 3074525 Regulation MMP7 ECM2 19298660 352769 Regulation MMP7 ECM2 23847438 1061521 Regulation MMP7 ECM2 25530657 738580 Regulation MMP7 EGF 15083203 424471 Regulation MMP7 EGF 24098477 2856588 Regulation MMP7 EGF 8471429 445008 Regulation MMP7 EGF 8471429 445009 Regulation MMP7 EGFR 24362507 502608 Regulation MMP7 EPHB2 21320340 259113 Regulation MMP7 EPHB2 21738525 922834 Regulation MMP7 ERBB2 23076342 2171047 Regulation MMP7 ERVK-6 24455428 3151118 Regulation MMP7 ETS1 22971289 472207 Regulation MMP7 ETS1 24281073 501624 Regulation MMP7 ETS1 25210488 1488734 Regulation MMP7 ETS2 24281073 501625 Regulation MMP7 ETS2 25210488 1488735 Regulation MMP7 ETV1 21673681 436923 Regulation MMP7 ETV1 23076342 2171048 Regulation MMP7 EZH2 22272343 2589709 Regulation MMP7 EZH2 22272343 2589710 Regulation MMP7 FASLG 24611063 911672 Regulation MMP7 FGF1 22292085 2593658 Regulation MMP7 FGF10 22292085 2593659 Regulation MMP7 FGF11 22292085 2593660 Regulation MMP7 FGF12 22292085 2593661 Regulation MMP7 FGF13 22292085 2593662 Regulation MMP7 FGF14 22292085 2593663 Regulation MMP7 FGF16 22292085 2593664 Regulation MMP7 FGF17 22292085 2593665 Regulation MMP7 FGF18 22292085 2593666 Regulation MMP7 FGF19 22292085 2593667 Regulation MMP7 FGF2 10684258 1256020 Regulation MMP7 FGF2 22292085 2593668 Regulation MMP7 FGF20 22292085 2593669 Regulation MMP7 FGF21 22292085 2593670 Regulation MMP7 FGF22 22292085 2593671 Regulation MMP7 FGF23 22292085 2593672 Regulation MMP7 FGF3 22292085 2593673 Regulation MMP7 FGF4 22292085 2593674 Regulation MMP7 FGF5 22292085 2593675 Regulation MMP7 FGF6 22292085 2593676 Regulation MMP7 FGF7 22292085 2593677 Regulation MMP7 FGF8 22292085 2593678 Regulation MMP7 FGF9 22292085 2593679 Regulation MMP7 FURIN 23936445 2830510 Regulation MMP7 GAST 20584780 1023272 Regulation MMP7 GAST 20584780 1023273 Regulation MMP7 GLRX 18560520 2390961 Regulation MMP7 GLRX 18560520 2391005 Regulation MMP7 GLRX 18560520 2391093 Regulation MMP7 HDAC1 15899037 103352 Regulation MMP7 HDAC1 24062615 1628796 Regulation MMP7 HDAC2 15899037 103353 Regulation MMP7 HDAC2 24062615 1628797 Regulation MMP7 HGF 10851027 1259203 Regulation MMP7 HGF 11027427 417900 Regulation MMP7 HMGB1 20799933 119947 Regulation MMP7 HMGB1 20799933 119948 Regulation MMP7 HMGB1 20799933 119949 Regulation MMP7 HPSE 19360105 2412800 Regulation MMP7 HPSE 22590508 2640757 Regulation MMP7 HRASLS 23687991 1232154 Regulation MMP7 HSPG2 23840737 2816262 Regulation MMP7 IDO1 11375052 224805 Regulation MMP7 IFI44 20109185 284195 Regulation MMP7 IGF1 22159423 1140657 Regulation MMP7 IGF1 24717414 1703672 Regulation MMP7 IGF1R 23061721 533174 Regulation MMP7 IL11 25352758 1716780 Regulation MMP7 IL13 15743487 102629 Regulation MMP7 IL13 15743487 102652 Regulation MMP7 IL17A 19014637 463247 Regulation MMP7 IL17A 19627579 116148 Regulation MMP7 IL17A 19627579 116200 Regulation MMP7 IL17A 19627579 116231 Regulation MMP7 IL1A 11714393 98522 Regulation MMP7 IL1A 19695094 116622 Regulation MMP7 IL1A 20799933 119950 Regulation MMP7 IL1A 20799933 119951 Regulation MMP7 IL1A 20799933 119952 Regulation MMP7 IL1A 22011328 660056 Regulation MMP7 IL1A 22710193 2253062 Regulation MMP7 IL1A 23965253 129088 Regulation MMP7 IL1RN 17760968 108929 Regulation MMP7 IL1RN 17760968 108930 Regulation MMP7 IL24 24270662 1632376 Regulation MMP7 INSR 23061721 533175 Regulation MMP7 JUN 14979937 100226 Regulation MMP7 JUN 17559674 108378 Regulation MMP7 JUN 18226189 110109 Regulation MMP7 JUN 20939893 1859807 Regulation MMP7 JUN 20939893 1859808 Regulation MMP7 JUN 20939893 1859815 Regulation MMP7 JUN 20964825 855180 Regulation MMP7 JUN 23226337 2724255 Regulation MMP7 JUN 24281073 501626 Regulation MMP7 JUN 24349175 2896989 Regulation MMP7 LPA 21876704 3172842 Regulation MMP7 LTB 12516548 2001403 Regulation MMP7 LXN 21762534 260567 Regulation MMP7 MAP4K4 24244164 3064990 Regulation MMP7 MAPK1 16906368 1769509 Regulation MMP7 MAPK1 19765281 117063 Regulation MMP7 MAPK1 21320340 259117 Regulation MMP7 MAPK1 21371008 451272 Regulation MMP7 MAPK1 21814482 1057501 Regulation MMP7 MAPK1 23587438 1666446 Regulation MMP7 MAPK1 23760725 2164773 Regulation MMP7 MAPK1 23760725 2164774 Regulation MMP7 MAPK1 23760725 2164775 Regulation MMP7 MAPK1 24204703 2874048 Regulation MMP7 MAPK1 24466137 2913618 Regulation MMP7 MAPK1 24664279 2938432 Regulation MMP7 MAPK1 25205985 90463 Regulation MMP7 MAPK10 16906368 1769510 Regulation MMP7 MAPK10 19765281 117064 Regulation MMP7 MAPK10 21320340 259118 Regulation MMP7 MAPK10 21371008 451273 Regulation MMP7 MAPK10 21814482 1057502 Regulation MMP7 MAPK10 23587438 1666447 Regulation MMP7 MAPK10 23760725 2164776 Regulation MMP7 MAPK10 23760725 2164777 Regulation MMP7 MAPK10 23760725 2164778 Regulation MMP7 MAPK10 24204703 2874049 Regulation MMP7 MAPK10 24466137 2913619 Regulation MMP7 MAPK10 24664279 2938433 Regulation MMP7 MAPK10 25205985 90464 Regulation MMP7 MAPK11 16906368 1769511 Regulation MMP7 MAPK11 19765281 117065 Regulation MMP7 MAPK11 21320340 259119 Regulation MMP7 MAPK11 21371008 451274 Regulation MMP7 MAPK11 21814482 1057503 Regulation MMP7 MAPK11 23587438 1666448 Regulation MMP7 MAPK11 23760725 2164779 Regulation MMP7 MAPK11 23760725 2164780 Regulation MMP7 MAPK11 23760725 2164781 Regulation MMP7 MAPK11 24204703 2874050 Regulation MMP7 MAPK11 24466137 2913620 Regulation MMP7 MAPK11 24664279 2938434 Regulation MMP7 MAPK11 25205985 90465 Regulation MMP7 MAPK12 16906368 1769512 Regulation MMP7 MAPK12 19765281 117066 Regulation MMP7 MAPK12 21320340 259120 Regulation MMP7 MAPK12 21371008 451275 Regulation MMP7 MAPK12 21814482 1057504 Regulation MMP7 MAPK12 23587438 1666449 Regulation MMP7 MAPK12 23760725 2164782 Regulation MMP7 MAPK12 23760725 2164783 Regulation MMP7 MAPK12 23760725 2164784 Regulation MMP7 MAPK12 24204703 2874051 Regulation MMP7 MAPK12 24466137 2913621 Regulation MMP7 MAPK12 24664279 2938435 Regulation MMP7 MAPK12 25205985 90466 Regulation MMP7 MAPK13 16906368 1769513 Regulation MMP7 MAPK13 19765281 117067 Regulation MMP7 MAPK13 21320340 259121 Regulation MMP7 MAPK13 21371008 451276 Regulation MMP7 MAPK13 21814482 1057505 Regulation MMP7 MAPK13 23587438 1666450 Regulation MMP7 MAPK13 23760725 2164785 Regulation MMP7 MAPK13 23760725 2164786 Regulation MMP7 MAPK13 23760725 2164787 Regulation MMP7 MAPK13 24204703 2874052 Regulation MMP7 MAPK13 24466137 2913622 Regulation MMP7 MAPK13 24664279 2938436 Regulation MMP7 MAPK13 25205985 90467 Regulation MMP7 MAPK14 16906368 1769514 Regulation MMP7 MAPK14 19765281 117068 Regulation MMP7 MAPK14 21320340 259122 Regulation MMP7 MAPK14 21371008 451277 Regulation MMP7 MAPK14 21814482 1057506 Regulation MMP7 MAPK14 23587438 1666451 Regulation MMP7 MAPK14 23760725 2164788 Regulation MMP7 MAPK14 23760725 2164789 Regulation MMP7 MAPK14 23760725 2164790 Regulation MMP7 MAPK14 24204703 2874053 Regulation MMP7 MAPK14 24466137 2913623 Regulation MMP7 MAPK14 24664279 2938437 Regulation MMP7 MAPK14 25205985 90468 Regulation MMP7 MAPK15 16906368 1769508 Regulation MMP7 MAPK15 19765281 117062 Regulation MMP7 MAPK15 21320340 259112 Regulation MMP7 MAPK15 21371008 451271 Regulation MMP7 MAPK15 21814482 1057500 Regulation MMP7 MAPK15 23587438 1666445 Regulation MMP7 MAPK15 23760725 2164770 Regulation MMP7 MAPK15 23760725 2164771 Regulation MMP7 MAPK15 23760725 2164772 Regulation MMP7 MAPK15 24204703 2874047 Regulation MMP7 MAPK15 24466137 2913617 Regulation MMP7 MAPK15 24664279 2938431 Regulation MMP7 MAPK15 25205985 90462 Regulation MMP7 MAPK3 16906368 1769515 Regulation MMP7 MAPK3 19765281 117069 Regulation MMP7 MAPK3 21320340 259123 Regulation MMP7 MAPK3 21371008 451278 Regulation MMP7 MAPK3 21814482 1057507 Regulation MMP7 MAPK3 23587438 1666452 Regulation MMP7 MAPK3 23760725 2164791 Regulation MMP7 MAPK3 23760725 2164792 Regulation MMP7 MAPK3 23760725 2164793 Regulation MMP7 MAPK3 23840737 2816263 Regulation MMP7 MAPK3 24204703 2874054 Regulation MMP7 MAPK3 24466137 2913624 Regulation MMP7 MAPK3 24664279 2938438 Regulation MMP7 MAPK3 25205985 90469 Regulation MMP7 MAPK4 16906368 1769516 Regulation MMP7 MAPK4 19765281 117070 Regulation MMP7 MAPK4 21320340 259124 Regulation MMP7 MAPK4 21371008 451279 Regulation MMP7 MAPK4 21814482 1057508 Regulation MMP7 MAPK4 23587438 1666453 Regulation MMP7 MAPK4 23760725 2164794 Regulation MMP7 MAPK4 23760725 2164795 Regulation MMP7 MAPK4 23760725 2164796 Regulation MMP7 MAPK4 24204703 2874055 Regulation MMP7 MAPK4 24466137 2913625 Regulation MMP7 MAPK4 24664279 2938439 Regulation MMP7 MAPK4 25205985 90470 Regulation MMP7 MAPK6 16906368 1769517 Regulation MMP7 MAPK6 19765281 117071 Regulation MMP7 MAPK6 21320340 259125 Regulation MMP7 MAPK6 21371008 451280 Regulation MMP7 MAPK6 21814482 1057509 Regulation MMP7 MAPK6 23587438 1666454 Regulation MMP7 MAPK6 23760725 2164797 Regulation MMP7 MAPK6 23760725 2164798 Regulation MMP7 MAPK6 23760725 2164799 Regulation MMP7 MAPK6 24204703 2874056 Regulation MMP7 MAPK6 24466137 2913626 Regulation MMP7 MAPK6 24664279 2938440 Regulation MMP7 MAPK6 25205985 90471 Regulation MMP7 MAPK7 16906368 1769518 Regulation MMP7 MAPK7 19765281 117072 Regulation MMP7 MAPK7 21320340 259126 Regulation MMP7 MAPK7 21371008 451281 Regulation MMP7 MAPK7 21814482 1057510 Regulation MMP7 MAPK7 23587438 1666455 Regulation MMP7 MAPK7 23760725 2164800 Regulation MMP7 MAPK7 23760725 2164801 Regulation MMP7 MAPK7 23760725 2164802 Regulation MMP7 MAPK7 24204703 2874057 Regulation MMP7 MAPK7 24466137 2913627 Regulation MMP7 MAPK7 24664279 2938441 Regulation MMP7 MAPK7 25205985 90472 Regulation MMP7 MAPK8 16906368 1769519 Regulation MMP7 MAPK8 19765281 117073 Regulation MMP7 MAPK8 21320340 259127 Regulation MMP7 MAPK8 21371008 451282 Regulation MMP7 MAPK8 21814482 1057511 Regulation MMP7 MAPK8 23028407 2219729 Regulation MMP7 MAPK8 23587438 1666456 Regulation MMP7 MAPK8 23760725 2164803 Regulation MMP7 MAPK8 23760725 2164804 Regulation MMP7 MAPK8 23760725 2164805 Regulation MMP7 MAPK8 24204703 2874058 Regulation MMP7 MAPK8 24466137 2913628 Regulation MMP7 MAPK8 24664279 2938442 Regulation MMP7 MAPK8 25205985 90473 Regulation MMP7 MAPK9 16906368 1769520 Regulation MMP7 MAPK9 19765281 117074 Regulation MMP7 MAPK9 21320340 259128 Regulation MMP7 MAPK9 21371008 451283 Regulation MMP7 MAPK9 21814482 1057512 Regulation MMP7 MAPK9 23587438 1666457 Regulation MMP7 MAPK9 23760725 2164806 Regulation MMP7 MAPK9 23760725 2164807 Regulation MMP7 MAPK9 23760725 2164808 Regulation MMP7 MAPK9 24204703 2874059 Regulation MMP7 MAPK9 24466137 2913629 Regulation MMP7 MAPK9 24664279 2938443 Regulation MMP7 MAPK9 25205985 90474 Regulation MMP7 MBTPS1 16636149 1329343 Regulation MMP7 MIF 16872482 106387 Regulation MMP7 MIF 23050964 89514 Regulation MMP7 MIF 24069610 184286 Regulation MMP7 MMP14 18762577 1356267 Regulation MMP7 MMP28 19375502 1731681 Regulation MMP7 MOG 19267908 385419 Regulation MMP7 MOK 18511846 706176 Regulation MMP7 MPO 12615902 1526099 Regulation MMP7 MPO 21547259 1749220 Regulation MMP7 MPO 22723783 958098 Regulation MMP7 MRC1 23937653 380419 Regulation MMP7 MRC2 23937653 380418 Regulation MMP7 MSC 24692869 1691223 Regulation MMP7 MSLN 23694968 3135774 Regulation MMP7 MSLN 23694968 3135990 Regulation MMP7 MSLN 23694968 3135996 Regulation MMP7 MSLN 23694968 3136011 Regulation MMP7 MTOR 23383143 2748383 Regulation MMP7 MTOR PMC4212306 3206456 Regulation MMP7 MTOR PMC4212306 3206574 Regulation MMP7 MUC16 23694968 3135995 Regulation MMP7 MUC16 23694968 3136010 Regulation MMP7 MYLIP 20023698 2128593 Regulation MMP7 MYLIP 23437250 2756308 Regulation MMP7 MYLIP 23857777 781465 Regulation MMP7 MYOF 22761893 2659100 Regulation MMP7 MYOF 22761893 2659123 Regulation MMP7 NA 21118526 2111669 Regulation MMP7 NA 21192843 623491 Regulation MMP7 NA 21283566 2495656 Regulation MMP7 NA 21998720 2562219 Regulation MMP7 NA 23760725 2164809 Regulation MMP7 NA 23760725 2164810 Regulation MMP7 NA 23760725 2164811 Regulation MMP7 NA 24091661 567269 Regulation MMP7 NA 24260080 2166961 Regulation MMP7 NA 24260080 2166962 Regulation MMP7 NA 24260080 2166963 Regulation MMP7 NEU1 23076342 2171049 Regulation MMP7 NFKB1 23226337 2724256 Regulation MMP7 NFKB1 PMC3405422 805134 Regulation MMP7 NOS3 22936987 2682616 Regulation MMP7 NOS3 24992254 2986400 Regulation MMP7 NOTCH1 24749110 1022589 Regulation MMP7 NOTCH2 24749110 1022590 Regulation MMP7 NOTCH3 24749110 1022591 Regulation MMP7 NOTCH4 24749110 1022592 Regulation MMP7 NOV 22353423 1661109 Regulation MMP7 NOV 22353423 1661160 Regulation MMP7 NOX1 23840100 1753783 Regulation MMP7 NOX3 23840100 1753784 Regulation MMP7 NOX4 23840100 1753785 Regulation MMP7 NOX5 23840100 1753782 Regulation MMP7 NPS 23940521 2831329 Regulation MMP7 NUP43 20109185 284196 Regulation MMP7 OSM 25057495 195497 Regulation MMP7 PARK7 20186336 2441671 Regulation MMP7 PECAM1 12591918 1291221 Regulation MMP7 PF4 22275902 956304 Regulation MMP7 PGD 23687991 1232155 Regulation MMP7 PI3 20459645 1854859 Regulation MMP7 PIK3CA 19775453 254208 Regulation MMP7 PIK3CA 21320340 259129 Regulation MMP7 PIK3CA 21799931 2539360 Regulation MMP7 PIK3CA 23383143 2748384 Regulation MMP7 PIK3CA 25147440 1761622 Regulation MMP7 PIK3R1 19775453 254209 Regulation MMP7 PIK3R1 21320340 259130 Regulation MMP7 PIK3R1 21799931 2539361 Regulation MMP7 PIK3R1 23383143 2748385 Regulation MMP7 PIK3R1 25147440 1761623 Regulation MMP7 PIP 19765281 117075 Regulation MMP7 PIP 19765281 117140 Regulation MMP7 PKD2 24336522 1820042 Regulation MMP7 PLAT 23565108 935295 Regulation MMP7 PLAT 24303218 2003324 Regulation MMP7 PLAU 24189182 787899 Regulation MMP7 PPARA PMC2756345 496245 Regulation MMP7 PRKAA1 23561047 509741 Regulation MMP7 PRKAA2 23561047 509742 Regulation MMP7 PRKAB1 23561047 509743 Regulation MMP7 PRKAB2 23561047 509744 Regulation MMP7 PRKAG1 23561047 509745 Regulation MMP7 PRKAG2 23561047 509746 Regulation MMP7 PRKD1 23562655 829789 Regulation MMP7 PROS1 18516228 3041326 Regulation MMP7 PTEN 24143235 2868028 Regulation MMP7 PTEN 24143235 2868040 Regulation MMP7 PTGS2 16831226 249509 Regulation MMP7 PTGS2 20169190 3046321 Regulation MMP7 PTGS2 21457581 3178081 Regulation MMP7 PTGS2 23552603 2156223 Regulation MMP7 PTGS2 23552603 2156288 Regulation MMP7 PTGS2 24704993 806943 Regulation MMP7 PTPRC 18779349 1551987 Regulation MMP7 QSOX1 23098186 472597 Regulation MMP7 RASGRF1 19678938 116475 Regulation MMP7 RBBP4 15899037 103354 Regulation MMP7 RBBP4 24062615 1628798 Regulation MMP7 RBBP7 15899037 103355 Regulation MMP7 RBBP7 24062615 1628799 Regulation MMP7 RBPJ 24971735 612546 Regulation MMP7 RELA 23226337 2724257 Regulation MMP7 RELA PMC3405422 805135 Regulation MMP7 RLN1 15642129 102060 Regulation MMP7 RLN1 16784544 106110 Regulation MMP7 RLN1 22936987 2682488 Regulation MMP7 RLN1 22936987 2682489 Regulation MMP7 RLN1 22936987 2682490 Regulation MMP7 RLN2 15642129 102061 Regulation MMP7 RLN2 16784544 106111 Regulation MMP7 RLN2 22936987 2682491 Regulation MMP7 RLN2 22936987 2682492 Regulation MMP7 RLN2 22936987 2682493 Regulation MMP7 RLN3 15642129 102062 Regulation MMP7 RLN3 16784544 106112 Regulation MMP7 RLN3 22936987 2682494 Regulation MMP7 RLN3 22936987 2682495 Regulation MMP7 RLN3 22936987 2682496 Regulation MMP7 RNF146 24454854 2910164 Regulation MMP7 RNF146 24454854 2910187 Regulation MMP7 RNF146 24454854 2910188 Regulation MMP7 RNF146 24454854 2910192 Regulation MMP7 S100A4 23922901 2827459 Regulation MMP7 SDC1 24136296 808873 Regulation MMP7 SERPINF1 22690122 1224372 Regulation MMP7 SETD2 21847402 1238219 Regulation MMP7 SFN 23072510 127020 Regulation MMP7 SIRT1 20920189 3110995 Regulation MMP7 SOCS1 24238405 130001 Regulation MMP7 SOX18 22292085 2593633 Regulation MMP7 SOX18 22292085 2593657 Regulation MMP7 SP1 24755270 272861 Regulation MMP7 SPP1 16128620 2368464 Regulation MMP7 SRC 20167811 2007835 Regulation MMP7 SSFA2 7537277 1436618 Regulation MMP7 STAT3 20939893 1859814 Regulation MMP7 STAT3 21991388 2561754 Regulation MMP7 STAT3 24107265 1870080 Regulation MMP7 STAT3 24199193 184804 Regulation MMP7 SULF2 22410125 471348 Regulation MMP7 SYT1 24755270 272862 Regulation MMP7 TAGLN 25050546 2991001 Regulation MMP7 TCF12 25029110 2989924 Regulation MMP7 TCF15 25029110 2989925 Regulation MMP7 TCF19 25029110 2989926 Regulation MMP7 TCF20 25029110 2989927 Regulation MMP7 TCF21 25029110 2989928 Regulation MMP7 TCF23 25029110 2989932 Regulation MMP7 TCF24 25029110 2989934 Regulation MMP7 TCF25 25029110 2989933 Regulation MMP7 TCF3 25029110 2989929 Regulation MMP7 TCF4 25029110 2989930 Regulation MMP7 TCF7 25029110 2989931 Regulation MMP7 TCF7L2 23965253 129602 Regulation MMP7 TERT 24388106 222517 Regulation MMP7 TET1 23533523 818120 Regulation MMP7 TET2 23533523 818118 Regulation MMP7 TET3 23533523 818119 Regulation MMP7 TFPI2 23905012 853482 Regulation MMP7 TGFB1 PMC3405422 805133 Regulation MMP7 TGFB1I1 24811612 1159590 Regulation MMP7 TGM2 24130925 204540 Regulation MMP7 THBS1 23749112 1107575 Regulation MMP7 TIMP1 20011114 3045830 Regulation MMP7 TIMP1 20011518 2433280 Regulation MMP7 TIMP1 21711826 519373 Regulation MMP7 TIMP1 21814555 2539850 Regulation MMP7 TIMP1 22701711 2652148 Regulation MMP7 TIMP1 22911824 2677028 Regulation MMP7 TIMP1 23029478 2698391 Regulation MMP7 TIMP1 23187000 219769 Regulation MMP7 TIMP1 24454910 2910374 Regulation MMP7 TIMP1 25076423 2993359 Regulation MMP7 TIMP2 21811685 1681588 Regulation MMP7 TIMP2 22911824 2677029 Regulation MMP7 TIMP2 23631818 3091908 Regulation MMP7 TLR1 17129374 107613 Regulation MMP7 TLR10 17129374 107621 Regulation MMP7 TLR2 17129374 107614 Regulation MMP7 TLR3 17129374 107615 Regulation MMP7 TLR4 17129374 107616 Regulation MMP7 TLR5 17129374 107617 Regulation MMP7 TLR6 17129374 107622 Regulation MMP7 TLR7 17129374 107618 Regulation MMP7 TLR8 17129374 107619 Regulation MMP7 TLR9 17129374 107620 Regulation MMP7 TLR9 24959259 2168910 Regulation MMP7 TLR9 24959259 2168911 Regulation MMP7 TNC 21818551 600184 Regulation MMP7 TNF 17118171 3096388 Regulation MMP7 TNF 18852869 1908446 Regulation MMP7 TNF 19889233 3097702 Regulation MMP7 TNF 21067565 397477 Regulation MMP7 TNF 21547259 1749219 Regulation MMP7 TNF 21912722 2223913 Regulation MMP7 TNF 23389627 1811874 Regulation MMP7 TNF 23750094 163643 Regulation MMP7 TNF 24144354 651721 Regulation MMP7 TNF 24926361 844535 Regulation MMP7 TNF 25250141 1148994 Regulation MMP7 TNFSF10 24611063 911664 Regulation MMP7 TNFSF11 24611063 911665 Regulation MMP7 TNFSF12 24611063 911666 Regulation MMP7 TNFSF13 23383143 2748382 Regulation MMP7 TNFSF13 24611063 911667 Regulation MMP7 TNFSF14 24611063 911668 Regulation MMP7 TNFSF15 24611063 911669 Regulation MMP7 TNFSF18 24611063 911670 Regulation MMP7 TNFSF4 24611063 911671 Regulation MMP7 TNFSF8 24611063 911673 Regulation MMP7 TNFSF9 24611063 911674 Regulation MMP7 TSPAN1 10491398 1250736 Regulation MMP7 TSPAN10 10491398 1250745 Regulation MMP7 TSPAN11 10491398 1250747 Regulation MMP7 TSPAN12 10491398 1250740 Regulation MMP7 TSPAN13 10491398 1250741 Regulation MMP7 TSPAN14 10491398 1250743 Regulation MMP7 TSPAN15 10491398 1250742 Regulation MMP7 TSPAN16 10491398 1250746 Regulation MMP7 TSPAN17 10491398 1250733 Regulation MMP7 TSPAN18 10491398 1250738 Regulation MMP7 TSPAN19 10491398 1250748 Regulation MMP7 TSPAN2 10491398 1250737 Regulation MMP7 TSPAN3 10491398 1250734 Regulation MMP7 TSPAN31 10491398 1250727 Regulation MMP7 TSPAN32 10491398 1250732 Regulation MMP7 TSPAN33 10491398 1250744 Regulation MMP7 TSPAN4 10491398 1250731 Regulation MMP7 TSPAN5 10491398 1250735 Regulation MMP7 TSPAN6 10491398 1250730 Regulation MMP7 TSPAN7 10491398 1250728 Regulation MMP7 TSPAN8 10491398 1250729 Regulation MMP7 TSPAN9 10491398 1250739 Regulation MMP7 UCP2 17472436 2262946 Regulation MMP7 VEGFA 21193734 717022 Regulation MMP7 WISP2 14636425 523483 Regulation MMP7 WNT1 16438732 3106378 Regulation MMP7 WNT1 23071438 3059863 Regulation MMP7 WNT1 23965253 129408 Regulation MMP7 WNT11 16438732 3106379 Regulation MMP7 WNT11 23071438 3059864 Regulation MMP7 WNT11 23965253 129409 Regulation MMP7 WNT16 16438732 3106384 Regulation MMP7 WNT16 23071438 3059869 Regulation MMP7 WNT16 23965253 129414 Regulation MMP7 WNT2 16438732 3106380 Regulation MMP7 WNT2 23071438 3059865 Regulation MMP7 WNT2 23965253 129410 Regulation MMP7 WNT3 16438732 3106381 Regulation MMP7 WNT3 23071438 3059866 Regulation MMP7 WNT3 23965253 129411 Regulation MMP7 WNT3A 24479426 131583 Regulation MMP7 WNT4 16438732 3106382 Regulation MMP7 WNT4 23071438 3059867 Regulation MMP7 WNT4 23965253 129412 Regulation MMP7 WNT5A 24757147 135813 Regulation MMP7 WNT6 16438732 3106383 Regulation MMP7 WNT6 23071438 3059868 Regulation MMP7 WNT6 23965253 129413 Regulation MMP7 WNT7A 24479426 131582 Regulation MMP8 AGR2 17129374 107636 Regulation MMP8 CAPN8 21501525 1505298 Regulation MMP8 EPHB2 21320340 259132 Regulation MMP8 EPHB2 21738525 922835 Regulation MMP8 MMP28 19375502 1731682 Regulation MMP8 PECAM1 12591918 1291222 Regulation MMP8 PLAT 23565108 935296 Regulation MMP8 PLAT 24303218 2003325 Regulation MMP8 PLAU 24189182 787900 Regulation MMP8 TFPI2 23905012 853483 Regulation MMP8 TGM2 24130925 204541 Regulation MMP8 TLR7 17129374 107630 Regulation MMP8 TNF 17118171 3096389 Regulation MMP8 TNF 18852869 1908447 Regulation MMP8 TNF 19889233 3097703 Regulation MMP8 TNF 21547259 1749221 Regulation MMP8 TNF 21912722 2223914 Regulation MMP8 TNF 23389627 1811875 Regulation MMP8 TNF 23750094 163644 Regulation MMP8 TNF 24144354 651722 Regulation MMP8 TNF 24683547 187711 Regulation MMP8 TNF 24926361 844536 Regulation MMP8 TNF 25250141 1148995 Regulation MMP8 TNFSF10 24611063 911675 Regulation MMP8 TSPAN1 10491398 1250758 Regulation MMP8 WNT7A 24479426 131584 Regulation MMP9 AGR2 17129374 107648 Regulation MMP9 ARSA 20137092 1722990 Regulation MMP9 ARSA 20137092 1722993 Regulation MMP9 CAPN8 21501525 1505312 Regulation MMP9 CEACAM6 25398131 3027590 Regulation MMP9 EPHB2 19144181 112480 Regulation MMP9 EPHB2 19272186 1227053 Regulation MMP9 EPHB2 20107538 1037437 Regulation MMP9 EPHB2 21320340 259151 Regulation MMP9 EPHB2 21738525 922836 Regulation MMP9 EPHB2 23139770 2713881 Regulation MMP9 EPHB2 24023938 2844271 Regulation MMP9 EPHB2 24205091 2875320 Regulation MMP9 EPHB2 24504172 2187108 Regulation MMP9 EPHB2 25499743 476606 Regulation MMP9 F2R 14711377 3095684 Regulation MMP9 F2R 22992722 988762 Regulation MMP9 F2R 22992722 988766 Regulation MMP9 ID1 24970809 2193990 Regulation MMP9 IL1B 22018279 124247 Regulation MMP9 IL1B 23922722 2826283 Regulation MMP9 LGALS7B 25277199 2203325 Regulation MMP9 MAP2K6 19144181 112486 Regulation MMP9 MAP2K6 23139770 2713887 Regulation MMP9 MAP2K6 24013225 2153540 Regulation MMP9 MMP28 19375502 1731683 Regulation MMP9 MMP28 23199061 804590 Regulation MMP9 MMP28 24978432 504578 Regulation MMP9 MMP7 23199061 804605 Regulation MMP9 MMP7 24978432 504596 Regulation MMP9 MUC16 23594194 3113598 Regulation MMP9 NES 22870054 1920653 Regulation MMP9 PECAM1 12591918 1291223 Regulation MMP9 PGC 17987121 2380295 Regulation MMP9 PLAT 20406488 328841 Regulation MMP9 PLAT 23565108 935297 Regulation MMP9 PLAT 24303218 2003326 Regulation MMP9 PLAU 24189182 787901 Regulation MMP9 PLAU 25222667 1730981 Regulation MMP9 PODXL 23596468 843109 Regulation MMP9 S100A7 23618129 3226595 Regulation MMP9 SRGN 21880179 623907 Regulation MMP9 TFPI2 23905012 853484 Regulation MMP9 TGM2 21943122 1863480 Regulation MMP9 TGM2 24130925 204483 Regulation MMP9 TGM2 24130925 204484 Regulation MMP9 TGM2 24130925 204488 Regulation MMP9 TGM2 24130925 204498 Regulation MMP9 TGM2 24130925 204542 Regulation MMP9 TLR7 17129374 107642 Regulation MMP9 TNF 10408860 414954 Regulation MMP9 TNF 16106101 1740053 Regulation MMP9 TNF 16423283 3106029 Regulation MMP9 TNF 17118171 3096390 Regulation MMP9 TNF 18852869 1908448 Regulation MMP9 TNF 19889233 3097704 Regulation MMP9 TNF 21547259 1749223 Regulation MMP9 TNF 21747731 1091440 Regulation MMP9 TNF 21747731 1091442 Regulation MMP9 TNF 21747731 1091447 Regulation MMP9 TNF 21867555 1659552 Regulation MMP9 TNF 21867555 1659570 Regulation MMP9 TNF 21912722 2223915 Regulation MMP9 TNF 22018279 124246 Regulation MMP9 TNF 22353423 1661115 Regulation MMP9 TNF 23341882 2741312 Regulation MMP9 TNF 23389627 1811876 Regulation MMP9 TNF 23587438 1666471 Regulation MMP9 TNF 23750094 163645 Regulation MMP9 TNF 23974988 1050738 Regulation MMP9 TNF 24085323 1142181 Regulation MMP9 TNF 24085323 1142182 Regulation MMP9 TNF 24085323 1142183 Regulation MMP9 TNF 24085323 1142184 Regulation MMP9 TNF 24085323 1142205 Regulation MMP9 TNF 24085323 1142206 Regulation MMP9 TNF 24085323 1142207 Regulation MMP9 TNF 24085323 1142208 Regulation MMP9 TNF 24085323 1142226 Regulation MMP9 TNF 24144354 651723 Regulation MMP9 TNF 24190483 1142425 Regulation MMP9 TNF 24223987 2877533 Regulation MMP9 TNF 24236107 2878567 Regulation MMP9 TNF 24502696 1233027 Regulation MMP9 TNF 24502696 1233055 Regulation MMP9 TNF 24502696 1233092 Regulation MMP9 TNF 24502696 1233361 Regulation MMP9 TNF 24864265 191758 Regulation MMP9 TNF 24926361 844537 Regulation MMP9 TNF 25009774 3094541 Regulation MMP9 TNF 25250141 1148996 Regulation MMP9 TNF 25393535 2373169 Regulation MMP9 TNF 25393535 2373170 Regulation MMP9 TNF 9743290 447887 Regulation MMP9 TNF 9743290 447888 Regulation MMP9 TNF 9743290 447889 Regulation MMP9 TNF 9743290 447890 Regulation MMP9 TNF 9743290 447892 Regulation MMP9 TNF 9743290 447893 Regulation MMP9 TNFSF10 21209944 2492480 Regulation MMP9 TNFSF10 24611063 911686 Regulation MMP9 TSPAN1 10491398 1250780 Regulation MMP9 VSNL1 20419170 2447185 Regulation MMP9 WIF1 20573255 1856529 Regulation MMP9 WNT7A 24479426 131586 Regulation MN1 MSX1 23316168 960812 Regulation MNAT1 CAPN8 20200223 1774809 Regulation MOCOS ITGAL 21980488 2560947 Regulation MOG MMP7 19267908 385420 Regulation MOK EPHB2 18226173 658914 Regulation MOK EPHB2 23358382 1149035 Regulation MOK S100B 21423669 3051388 Regulation MOK S100B 24988410 2986170 Regulation MOS ITGB2 19175917 352572 Regulation MPL PLAGL1 21263445 1720194 Regulation MPO ARSA 16192667 1740109 Regulation MPO ARSA 24381411 1756237 Regulation MPO ARSA 24381411 1756238 Regulation MPO ARSA 25045574 1082999 Regulation MPO MMP28 21547259 1749230 Regulation MPO MMP7 21547259 1749245 Regulation MPO S100B 25345916 3129588 Regulation MPO TNF 22889165 1664763 Regulation MRC1 RAB31 22753895 1398773 Regulation MRE11A PECAM1 10725328 1256592 Regulation MRE11A TLR7 25118589 1945135 Regulation MRXS5 EPHB2 19684611 8026 Regulation MS NT5E 18553155 3089983 Regulation MSC TLR7 22783256 902127 Regulation MSC TLR7 24391353 1756459 Regulation MSC TLR7 24391353 1756460 Regulation MSC TLR7 24391353 1756461 Regulation MSC TLR7 24391353 1756494 Regulation MSC TLR7 24391353 1756505 Regulation MSC TLR7 24391353 1756515 Regulation MSC TLR7 25279386 1905695 Regulation MSH3 MAP2K6 23320839 482771 Regulation MSH3 TNF 23642074 1666695 Regulation MSH6 PGC 22548174 1155570 Regulation MSK10 EPHB2 24058693 2848573 Regulation MSK10 TNF 24705157 985099 Regulation MSK32 EPHB2 24058693 2848574 Regulation MSK32 TNF 24705157 985101 Regulation MSK38 EPHB2 24058693 2848575 Regulation MSK38 TNF 24705157 985103 Regulation MSK9 EPHB2 24058693 2848576 Regulation MSK9 TNF 24705157 985105 Regulation MSLN MUC16 23694968 3135857 Regulation MSN EPHB2 25406076 3028325 Regulation MSN NES 18541028 251062 Regulation MSR1 TNF 25250731 3009905 Regulation MSR1 TNF 25250731 3009907 Regulation MSTN CCND1 22427853 2610422 Regulation MSTN EPHB2 20419100 2446956 Regulation MSTN EPHB2 20419100 2446957 Regulation MSTN EPHB2 20419100 2446961 Regulation MSTN EPHB2 20419100 2446987 Regulation MSTN EPHB2 20419100 2446988 Regulation MSTN EPHB2 21048967 2480258 Regulation MSX1 BMP1 17068080 2023355 Regulation MSX1 BMP1 18404215 2305187 Regulation MSX1 BMP1 22140629 3086098 Regulation MSX1 BMP10 17068080 2023363 Regulation MSX1 BMP10 18404215 2305195 Regulation MSX1 BMP10 22140629 3086106 Regulation MSX1 BMP15 17068080 2023356 Regulation MSX1 BMP15 18404215 2305188 Regulation MSX1 BMP15 22140629 3086099 Regulation MSX1 BMP2 17068080 2023357 Regulation MSX1 BMP2 18404215 2305189 Regulation MSX1 BMP2 22140629 3086100 Regulation MSX1 BMP2 24160254 345737 Regulation MSX1 BMP3 17068080 2023358 Regulation MSX1 BMP3 18404215 2305190 Regulation MSX1 BMP3 22140629 3086101 Regulation MSX1 BMP4 16157866 2017597 Regulation MSX1 BMP4 17068080 2023359 Regulation MSX1 BMP4 18404215 2305191 Regulation MSX1 BMP4 22140629 3086102 Regulation MSX1 BMP4 23316168 960789 Regulation MSX1 BMP4 24160254 345738 Regulation MSX1 BMP4 24550718 2299812 Regulation MSX1 BMP4 24550718 2300299 Regulation MSX1 BMP5 17068080 2023360 Regulation MSX1 BMP5 18404215 2305192 Regulation MSX1 BMP5 22140629 3086103 Regulation MSX1 BMP6 17068080 2023361 Regulation MSX1 BMP6 18404215 2305193 Regulation MSX1 BMP6 22140629 3086104 Regulation MSX1 BMP7 17068080 2023362 Regulation MSX1 BMP7 18404215 2305194 Regulation MSX1 BMP7 22140629 3086105 Regulation MSX1 CDH2 22254040 2115988 Regulation MSX1 DLX1 23382810 2746346 Regulation MSX1 DLX2 23382810 2746347 Regulation MSX1 DLX3 23382810 2746348 Regulation MSX1 DLX4 23382810 2746349 Regulation MSX1 DLX5 23382810 2746350 Regulation MSX1 DLX6 23382810 2746344 Regulation MSX1 DLX6 23382810 2746351 Regulation MSX1 EHMT2 22629437 2646491 Regulation MSX1 EHMT2 22629437 2646492 Regulation MSX1 FGF1 17068080 2023364 Regulation MSX1 FGF10 17068080 2023365 Regulation MSX1 FGF11 17068080 2023366 Regulation MSX1 FGF12 17068080 2023367 Regulation MSX1 FGF13 17068080 2023368 Regulation MSX1 FGF14 17068080 2023369 Regulation MSX1 FGF16 17068080 2023370 Regulation MSX1 FGF17 17068080 2023371 Regulation MSX1 FGF18 17068080 2023372 Regulation MSX1 FGF19 17068080 2023373 Regulation MSX1 FGF2 17068080 2023374 Regulation MSX1 FGF20 17068080 2023375 Regulation MSX1 FGF21 17068080 2023376 Regulation MSX1 FGF22 17068080 2023377 Regulation MSX1 FGF23 17068080 2023378 Regulation MSX1 FGF3 17068080 2023379 Regulation MSX1 FGF4 17068080 2023380 Regulation MSX1 FGF5 17068080 2023381 Regulation MSX1 FGF6 17068080 2023382 Regulation MSX1 FGF7 17068080 2023383 Regulation MSX1 FGF7 23316168 960790 Regulation MSX1 FGF8 17068080 2023384 Regulation MSX1 FGF8 24160254 345739 Regulation MSX1 FGF9 17068080 2023385 Regulation MSX1 GATA4 23620817 2783522 Regulation MSX1 HOXA2 23316168 960743 Regulation MSX1 HOXB1 21433221 3171449 Regulation MSX1 LIF 17462098 3096432 Regulation MSX1 LMX1A 21829537 2541640 Regulation MSX1 MN1 23316168 960813 Regulation MSX1 PAX9 19591819 698124 Regulation MSX1 PAX9 24160254 345740 Regulation MSX1 SPRY2 23316168 960780 Regulation MSX1 WNT1 23055979 959188 Regulation MSX1 WNT1 23055979 959189 Regulation MSX1 WNT1 23055979 959190 Regulation MSX1 WNT1 23055979 959231 Regulation MSX1 WNT11 23055979 959191 Regulation MSX1 WNT11 23055979 959192 Regulation MSX1 WNT11 23055979 959193 Regulation MSX1 WNT11 23055979 959232 Regulation MSX1 WNT16 23055979 959206 Regulation MSX1 WNT16 23055979 959207 Regulation MSX1 WNT16 23055979 959208 Regulation MSX1 WNT16 23055979 959237 Regulation MSX1 WNT2 23055979 959194 Regulation MSX1 WNT2 23055979 959195 Regulation MSX1 WNT2 23055979 959196 Regulation MSX1 WNT2 23055979 959233 Regulation MSX1 WNT3 23055979 959197 Regulation MSX1 WNT3 23055979 959198 Regulation MSX1 WNT3 23055979 959199 Regulation MSX1 WNT3 23055979 959234 Regulation MSX1 WNT4 23055979 959200 Regulation MSX1 WNT4 23055979 959201 Regulation MSX1 WNT4 23055979 959202 Regulation MSX1 WNT4 23055979 959235 Regulation MSX1 WNT6 23055979 959203 Regulation MSX1 WNT6 23055979 959204 Regulation MSX1 WNT6 23055979 959205 Regulation MSX1 WNT6 23055979 959236 Regulation MSX1 WNT7B 23383281 2750020 Regulation MT-CO2 CA12 23869188 1084705 Regulation MT1E FAS 22291036 1394915 Regulation MTDH CEACAM6 24586388 2924442 Regulation MTDH TNF 22768080 2659639 Regulation MTOR ALDH2 22524197 358550 Regulation MTOR ARSA 24901243 2976452 Regulation MTOR AXIN2 22319467 929529 Regulation MTOR CCND1 23818927 820587 Regulation MTOR EPHB2 21200439 2489530 Regulation MTOR EPHB2 21283628 2497027 Regulation MTOR EPHB2 22028687 860565 Regulation MTOR EPHB2 23077579 2704800 Regulation MTOR EPHB2 23077579 2704801 Regulation MTOR EPHB2 23077579 2704802 Regulation MTOR EPHB2 23077579 2704813 Regulation MTOR EPHB2 23197407 779569 Regulation MTOR EPHB2 23431403 2755378 Regulation MTOR EPHB2 23431403 2755425 Regulation MTOR EPHB2 23431403 2755436 Regulation MTOR EPHB2 23531532 1103331 Regulation MTOR EPHB2 23754976 930935 Regulation MTOR EPHB2 24303063 2887913 Regulation MTOR EPHB2 24611062 880286 Regulation MTOR FOXO1 22489168 1095464 Regulation MTOR FOXO1 23183047 1570195 Regulation MTOR FOXO1 24498161 2918741 Regulation MTOR MAP2K6 18729301 3231435 Regulation MTOR MAP2K6 22564882 2180162 Regulation MTOR MAP2K6 23531532 1103339 Regulation MTOR PGC 22351927 1395778 Regulation MTOR PGC 24352740 2212468 Regulation MTOR RAB31 22523661 1670413 Regulation MTOR RAB31 23892275 18247 Regulation MTOR RIC3 18591430 1353355 Regulation MTOR STK39 19229373 686335 Regulation MTOR TLR7 24740015 2954251 Regulation MTOR TNF 22363816 2602081 Regulation MTTER RNASE1 18033800 2031929 Regulation MTTER RNASE7 18033800 2031937 Regulation MTTP FOXO1 20423497 2112648 Regulation MUC1 AGR2 23635006 473284 Regulation MUC1 EPHB2 16491824 1711345 Regulation MUC1 MAP2K6 22216327 2585623 Regulation MUC1 RAB31 22792175 2661059 Regulation MUC1 RAB31 22792175 2661081 Regulation MUC1 RAB31 25472813 1486010 Regulation MUC1 S100A7 23300877 2736924 Regulation MUC1 TNF 12482999 1633957 Regulation MUC1 TNF 21949848 2556889 Regulation MUC1 TNF 24453426 1757072 Regulation MUC12 AGR2 23635006 473285 Regulation MUC12 EPHB2 16491824 1711346 Regulation MUC12 TNF 12482999 1633959 Regulation MUC12 TNF 21949848 2556890 Regulation MUC12 TNF 24453426 1757073 Regulation MUC13 AGR2 23635006 473286 Regulation MUC13 EPHB2 16491824 1711347 Regulation MUC13 TNF 12482999 1633961 Regulation MUC13 TNF 21949848 2556891 Regulation MUC13 TNF 24453426 1757074 Regulation MUC15 AGR2 23635006 473278 Regulation MUC15 EPHB2 16491824 1711339 Regulation MUC15 TNF 12482999 1633941 Regulation MUC15 TNF 21949848 2556883 Regulation MUC15 TNF 24453426 1757066 Regulation MUC16 AGR2 23635006 473279 Regulation MUC16 APC 23741618 749300 Regulation MUC16 APC 23741618 749315 Regulation MUC16 ATOH1 22719768 1143470 Regulation MUC16 CA2 11004201 1607085 Regulation MUC16 CA2 21283816 2498362 Regulation MUC16 CA2 23741618 749249 Regulation MUC16 CA2 23741618 749285 Regulation MUC16 CARD11 22303480 2595092 Regulation MUC16 CDX2 19412438 669014 Regulation MUC16 CISH 8217607 444655 Regulation MUC16 CISH 8795574 445599 Regulation MUC16 CRH 20808677 1635271 Regulation MUC16 CSE 24905583 2977375 Regulation MUC16 DTX1 21931707 2554194 Regulation MUC16 DTX2 21931707 2554191 Regulation MUC16 DTX3 21931707 2554192 Regulation MUC16 DTX4 21931707 2554193 Regulation MUC16 DUOX1 23691121 2794620 Regulation MUC16 EGFR 22496644 3056056 Regulation MUC16 EPHB2 16491824 1711340 Regulation MUC16 FGFR1 24958148 1767285 Regulation MUC16 FGFR2 24958148 1767286 Regulation MUC16 FGFR3 24958148 1767287 Regulation MUC16 FGFR3 8270909 1612629 Regulation MUC16 FGFR4 24958148 1767288 Regulation MUC16 GNAS 23403822 440241 Regulation MUC16 GNAS 23403822 440242 Regulation MUC16 GNAS 24498386 2919319 Regulation MUC16 GNAS 24498386 2919320 Regulation MUC16 HSPG2 22013477 695874 Regulation MUC16 IL13 25147434 1761160 Regulation MUC16 IL17A 25147434 1761161 Regulation MUC16 IL1A 12482999 1633944 Regulation MUC16 IL1A 12482999 1634029 Regulation MUC16 IL4 15203548 1739495 Regulation MUC16 IL4 16551361 3106918 Regulation MUC16 MAPK1 12482999 1633484 Regulation MUC16 MAPK1 16491824 1711020 Regulation MUC16 MAPK1 22977714 646417 Regulation MUC16 MAPK10 12482999 1633485 Regulation MUC16 MAPK10 16491824 1711021 Regulation MUC16 MAPK10 22977714 646418 Regulation MUC16 MAPK11 12482999 1633486 Regulation MUC16 MAPK11 16491824 1711022 Regulation MUC16 MAPK11 22977714 646419 Regulation MUC16 MAPK12 12482999 1633487 Regulation MUC16 MAPK12 16491824 1711023 Regulation MUC16 MAPK12 22977714 646420 Regulation MUC16 MAPK13 12482999 1633488 Regulation MUC16 MAPK13 16491824 1711024 Regulation MUC16 MAPK13 22977714 646421 Regulation MUC16 MAPK14 12482999 1633489 Regulation MUC16 MAPK14 16491824 1711025 Regulation MUC16 MAPK14 22977714 646422 Regulation MUC16 MAPK15 12482999 1633483 Regulation MUC16 MAPK15 16491824 1711019 Regulation MUC16 MAPK15 22977714 646416 Regulation MUC16 MAPK3 12482999 1633490 Regulation MUC16 MAPK3 16491824 1711026 Regulation MUC16 MAPK3 16491824 1711226 Regulation MUC16 MAPK3 22977714 646423 Regulation MUC16 MAPK4 12482999 1633491 Regulation MUC16 MAPK4 16491824 1711027 Regulation MUC16 MAPK4 22977714 646424 Regulation MUC16 MAPK6 12482999 1633492 Regulation MUC16 MAPK6 16491824 1711028 Regulation MUC16 MAPK6 22977714 646425 Regulation MUC16 MAPK7 12482999 1633493 Regulation MUC16 MAPK7 16491824 1711029 Regulation MUC16 MAPK7 22977714 646426 Regulation MUC16 MAPK8 12482999 1633494 Regulation MUC16 MAPK8 16491824 1711030 Regulation MUC16 MAPK8 22977714 646427 Regulation MUC16 MAPK9 12482999 1633495 Regulation MUC16 MAPK9 16491824 1711031 Regulation MUC16 MAPK9 22977714 646428 Regulation MUC16 MECOM 17029558 2303377 Regulation MUC16 MMP9 22412870 2609423 Regulation MUC16 MUC4 16551361 3106919 Regulation MUC16 MUC5AC 23053395 3158191 Regulation MUC16 MYD88 PMC3552307 92113 Regulation MUC16 MYLIP 24204560 2872939 Regulation MUC16 NAMPT 24885580 1233832 Regulation MUC16 NAMPT 24885580 1233934 Regulation MUC16 NAMPT 24885580 1234020 Regulation MUC16 NELFCD 24386378 2903814 Regulation MUC16 NGF 21179428 1912474 Regulation MUC16 NOS1 9400742 797557 Regulation MUC16 NOS2 21603133 1081789 Regulation MUC16 NOS2 9400742 797558 Regulation MUC16 NOS3 21603133 1081790 Regulation MUC16 NOS3 9400742 797559 Regulation MUC16 NR4A3 17391532 3107979 Regulation MUC16 OSCP1 17391532 3107978 Regulation MUC16 PAK1 22768318 2660495 Regulation MUC16 PAK2 22768318 2660496 Regulation MUC16 PAK3 22768318 2660497 Regulation MUC16 PAK4 22768318 2660493 Regulation MUC16 PAK6 22768318 2660494 Regulation MUC16 PAK7 22768318 2660492 Regulation MUC16 PI3 12482999 1633891 Regulation MUC16 PIK3CA 12482999 1634030 Regulation MUC16 PIK3R1 12482999 1634031 Regulation MUC16 PRSS27 23102107 1617619 Regulation MUC16 PTGS2 22013477 695875 Regulation MUC16 SETD2 23462909 1919797 Regulation MUC16 SPDEF 21203431 2490227 Regulation MUC16 STAT6 21203431 2490226 Regulation MUC16 TGFB1 15203548 1739538 Regulation MUC16 TIMP1 20459644 255955 Regulation MUC16 TLR2 19656404 353041 Regulation MUC16 TLR3 23282443 3225284 Regulation MUC16 TNF 12482999 1633943 Regulation MUC16 TNF 21949848 2556884 Regulation MUC16 TNF 24453426 1757067 Regulation MUC16 TRPM5 23741618 749250 Regulation MUC17 AGR2 23635006 473280 Regulation MUC17 EPHB2 16491824 1711341 Regulation MUC17 TNF 12482999 1633945 Regulation MUC17 TNF 21949848 2556885 Regulation MUC17 TNF 24453426 1757068 Regulation MUC19 AGR2 23635006 473277 Regulation MUC19 EPHB2 16491824 1711338 Regulation MUC19 TNF 12482999 1633939 Regulation MUC19 TNF 21949848 2556882 Regulation MUC19 TNF 24453426 1757065 Regulation MUC2 AGR2 23635006 473287 Regulation MUC2 EPHB2 16491824 1711348 Regulation MUC2 EPHB2 24498386 2919335 Regulation MUC2 MUC16 21949848 2556901 Regulation MUC2 TNF 12482999 1633963 Regulation MUC2 TNF 21949848 2556892 Regulation MUC2 TNF 22162748 2577619 Regulation MUC2 TNF 23723167 780906 Regulation MUC2 TNF 24453426 1757075 Regulation MUC20 AGR2 23635006 473282 Regulation MUC20 EPHB2 16491824 1711343 Regulation MUC20 TNF 12482999 1633949 Regulation MUC20 TNF 21949848 2556887 Regulation MUC20 TNF 24453426 1757070 Regulation MUC21 AGR2 23635006 473281 Regulation MUC21 EPHB2 16491824 1711342 Regulation MUC21 TNF 12482999 1633947 Regulation MUC21 TNF 21949848 2556886 Regulation MUC21 TNF 24453426 1757069 Regulation MUC22 AGR2 23635006 473283 Regulation MUC22 EPHB2 16491824 1711344 Regulation MUC22 TNF 12482999 1633951 Regulation MUC22 TNF 21949848 2556888 Regulation MUC22 TNF 24453426 1757071 Regulation MUC4 AGR2 23635006 473288 Regulation MUC4 EPHB2 16491824 1711349 Regulation MUC4 MAP2K6 22537161 1865643 Regulation MUC4 MUC16 16551361 3106939 Regulation MUC4 TNF 12482999 1633965 Regulation MUC4 TNF 21949848 2556893 Regulation MUC4 TNF 24453426 1757076 Regulation MUC5AC ALOX5 11324902 1737773 Regulation MUC5AC EPHB2 16491824 1711350 Regulation MUC5AC EPHB2 24027752 183916 Regulation MUC5AC EPHB2 24498386 2919340 Regulation MUC5AC MUC16 23053395 3158203 Regulation MUC5AC MUC16 24905583 2977387 Regulation MUC5AC TLR7 22303480 2594808 Regulation MUC5AC TLR7 22303480 2594996 Regulation MUC5AC TLR7 22303480 2595052 Regulation MUC5AC TLR7 22303480 2595053 Regulation MUC5AC TNF 19668469 649350 Regulation MUC5AC TNF 25398130 3027514 Regulation MUC6 AGR2 23635006 473289 Regulation MUC6 EPHB2 16491824 1711351 Regulation MUC6 TNF 12482999 1633967 Regulation MUC6 TNF 21949848 2556894 Regulation MUC6 TNF 24453426 1757077 Regulation MUC7 AGR2 23635006 473290 Regulation MUC7 EPHB2 16491824 1711352 Regulation MUC7 TGM2 24921197 653875 Regulation MUC7 TNF 12482999 1633969 Regulation MUC7 TNF 21949848 2556895 Regulation MUC7 TNF 24453426 1757078 Regulation MUC8 AGR2 23635006 473291 Regulation MUC8 EPHB2 16491824 1711353 Regulation MUC8 TNF 12482999 1633971 Regulation MUC8 TNF 21949848 2556896 Regulation MUC8 TNF 24453426 1757079 Regulation MUT FOXO1 21541341 2516993 Regulation MVD ADAMTS1 20546609 256266 Regulation MVD ADAMTS1 20546609 256269 Regulation MX1 MX2 19825344 3209757 Regulation MX2 MX1 19825344 3209758 Regulation MYB JAG1 23115560 968869 Regulation MYBL1 TNF 23049873 2699762 Regulation MYBPC1 FBXO32 22028912 2565143 Regulation MYBPC2 FBXO32 22028912 2565145 Regulation MYBPC3 FBXO32 22028912 2565147 Regulation MYBPC3 TNNT2 23233322 1243946 Regulation MYC AXIN2 19262462 764070 Regulation MYC CCND1 24349321 2897480 Regulation MYC EPHB2 15811177 1844546 Regulation MYC EPHB2 16899113 1845506 Regulation MYC EPHB2 16899113 1845517 Regulation MYC EPHB2 18463697 2289716 Regulation MYC EPHB2 23300995 2737824 Regulation MYC EPHB2 23437333 2756481 Regulation MYC EPHB2 24416646 1708134 Regulation MYC EPHB2 24457827 2186902 Regulation MYC FOLR1 17579712 2376567 Regulation MYC FOXO1 20089194 284067 Regulation MYC FOXO1 24583874 545755 Regulation MYC FOXO1 24977668 2194645 Regulation MYC ID1 24137437 2165752 Regulation MYC KRT38 25433490 349868 Regulation MYC MAP2K6 16899113 1845512 Regulation MYC MAP2K6 16899113 1845525 Regulation MYC MAP2K6 23227266 2725960 Regulation MYC MAP2K6 23437333 2756490 Regulation MYC MAP2K6 23867226 700647 Regulation MYC MUC16 24204606 2873122 Regulation MYC ZBTB16 21824427 363070 Regulation MYCN EPHB2 9432981 1602458 Regulation MYD88 TLR7 15223603 1739714 Regulation MYD88 TLR7 18066067 1951766 Regulation MYD88 TLR7 18824587 1552231 Regulation MYD88 TLR7 18946505 2399112 Regulation MYD88 TLR7 22643865 1905634 Regulation MYD88 TLR7 23483993 2764949 Regulation MYD88 TNF 25426709 3030155 Regulation MYH16 HIST1H3H 22771996 3187879 Regulation MYH16 KLF5 21951574 3112763 Regulation MYH16 MSC 24710543 619490 Regulation MYH16 MYF5 22541644 3161057 Regulation MYH16 MYOCD 21352594 376350 Regulation MYH16 REPIN1 23935420 3154967 Regulation MYH16 SIX1 24852826 2359380 Regulation MYH16 SIX1 24852826 2359381 Regulation MYH16 SIX1 24852826 2359435 Regulation MYH16 SIX4 24852826 2359477 Regulation MYH16 SMAD3 23620745 2783205 Regulation MYH16 SMAD3 24718260 2950556 Regulation MYH16 SMARCA4 23740219 142966 Regulation MYH16 SNAP25 8896595 1456824 Regulation MYH16 SRF 21352594 376349 Regulation MYH16 TAC1 24086300 2853873 Regulation MYH16 TAC3 24086300 2853874 Regulation MYH16 TAC4 24086300 2853875 Regulation MYH2 TNF 24453411 1756657 Regulation MYH2 TNF 24453411 1756663 Regulation MYH2 TNF 24453411 1756664 Regulation MYH3 HIST1H3H 22771996 3187887 Regulation MYH3 KLF5 21951574 3112771 Regulation MYH3 MSC 24710543 619497 Regulation MYH3 MYF5 22541644 3161064 Regulation MYH3 MYOCD 21352594 376364 Regulation MYH3 REPIN1 23935420 3154974 Regulation MYH3 SIX1 24852826 2359394 Regulation MYH3 SIX1 24852826 2359395 Regulation MYH3 SIX1 24852826 2359442 Regulation MYH3 SIX4 24852826 2359484 Regulation MYH3 SMAD3 23620745 2783212 Regulation MYH3 SMAD3 24718260 2950563 Regulation MYH3 SMARCA4 23740219 142973 Regulation MYH3 SNAP25 8896595 1456831 Regulation MYH3 SRF 21352594 376363 Regulation MYH3 TAC1 24086300 2853894 Regulation MYH3 TAC3 24086300 2853895 Regulation MYH3 TAC4 24086300 2853896 Regulation MYL1 MAP2K6 23826126 2810386 Regulation MYL10 MAP2K6 23826126 2810376 Regulation MYL12B TNF 22688336 723187 Regulation MYL2 MAP2K6 23826126 2810396 Regulation MYL3 MAP2K6 23826126 2810406 Regulation MYL4 MAP2K6 23826126 2810416 Regulation MYL5 MAP2K6 23826126 2810426 Regulation MYL6 MAP2K6 23826126 2810436 Regulation MYL7 MAP2K6 23826126 2810366 Regulation MYL9 MAP2K6 23826126 2810356 Regulation MYLIP CCND1 20948989 2174559 Regulation MYLIP CCND1 20948989 2174560 Regulation MYLIP CCND1 22912826 2679566 Regulation MYLIP CCND1 22942717 1097077 Regulation MYLIP CCND1 22942717 1097078 Regulation MYLIP CCND1 24744457 738416 Regulation MYLIP CCND1 25289101 2169775 Regulation MYLIP CDKN1C 24308935 1158400 Regulation MYLIP CTGF 20393144 713778 Regulation MYLIP CTGF 21501375 32647 Regulation MYLIP CTGF 23688035 1232181 Regulation MYLIP CTGF 25003330 2195005 Regulation MYLIP CTGF 25124875 1483826 Regulation MYLIP EPHB2 21266476 2060290 Regulation MYLIP EPHB2 22916239 2680361 Regulation MYLIP EPHB2 23469214 2763228 Regulation MYLIP EPHB2 23469214 2763229 Regulation MYLIP EPHB2 23469214 2763248 Regulation MYLIP EPHB2 23469214 2763282 Regulation MYLIP EPHB2 23633945 3060726 Regulation MYLIP EPHB2 23633945 3060727 Regulation MYLIP EPHB2 23633945 3060770 Regulation MYLIP EPHB2 24349829 478329 Regulation MYLIP FAS 23166734 2718791 Regulation MYLIP FAS 23166734 2718831 Regulation MYLIP FAS 25333257 2205582 Regulation MYLIP FHL1 21261953 393710 Regulation MYLIP FHL1 24885979 395025 Regulation MYLIP FHL1 25414712 971832 Regulation MYLIP IFI27 22754369 1096175 Regulation MYLIP IFI27 24727437 2188818 Regulation MYLIP IFI27 24727437 2188819 Regulation MYLIP IFI27 24727437 2188820 Regulation MYLIP IFI27 24727437 2188838 Regulation MYLIP IFI27 24727437 2188839 Regulation MYLIP IFI27 24727952 2951761 Regulation MYLIP IFI27 24727952 2951763 Regulation MYLIP IFI27 25433493 1510899 Regulation MYLIP KLF9 24349493 2898341 Regulation MYLIP KLF9 PMC3757848 3086689 Regulation MYLIP LAMB3 23483249 1141572 Regulation MYLIP MAP2K6 24448661 3139572 Regulation MYLIP NES 23016664 387836 Regulation MYLIP NES 23016664 387855 Regulation MYLIP NR2F1 24349493 2898331 Regulation MYLIP NR2F1 24349493 2898335 Regulation MYLIP NR2F1 24349493 2898342 Regulation MYLIP NR2F1 24349493 2898350 Regulation MYLIP NR2F1 24349493 2898356 Regulation MYLIP PLAU 23864708 1816998 Regulation MYLIP RCAN1 19603121 1832576 Regulation MYLIP TLR7 20041145 2435428 Regulation MYLIP TLR7 20041145 2435429 Regulation MYLIP TLR7 20041145 2435464 Regulation MYLIP TLR7 20144951 2052341 Regulation MYLIP TLR7 22846613 1698669 Regulation MYLIP TLR7 23076273 3217205 Regulation MYLIP TLR7 23762086 637694 Regulation MYLIP TLR7 24351865 1122537 Regulation MYLIP TLR7 24932654 2980373 Regulation MYLIP TNF 19823581 2428102 Regulation MYLIP TNF 20459811 118931 Regulation MYLIP TNF 21029443 3111549 Regulation MYLIP TNF 21611196 2523867 Regulation MYLIP TNF 22518321 1079155 Regulation MYLIP TNF 22615562 3056749 Regulation MYLIP TNF 23056947 1145812 Regulation MYLIP TNF 23592910 1915796 Regulation MYLIP TNF 23592910 1915797 Regulation MYLIP TNF 24086143 2350875 Regulation MYLIP TNF 24098322 2855796 Regulation MYLIP TNF 24113581 1113264 Regulation MYLIP TNF 24179536 2166241 Regulation MYLIP TNF 24369540 1495487 Regulation MYLIP TNF 24587348 2929698 Regulation MYLIP TNF 24688608 2208348 Regulation MYLIP TNF 24885472 1701852 Regulation MYLIP TNF 24971753 2985083 Regulation MYLIP TNF 25182190 381604 Regulation MYLIP TNFSF10 24941171 2980831 Regulation MYLIP TP63 23545251 2182981 Regulation MYLIP TP63 23710361 1690492 Regulation MYLIP TP63 24396276 679778 Regulation MYLIP TP63 25168241 549173 Regulation MYLIP WIF1 24853424 576266 Regulation MYLIP WNT7A 23862015 170008 Regulation MYLIP WNT7A 23862015 170009 Regulation MYLIP WNT7A 23862015 170010 Regulation MYLIP WNT7A 23862015 170034 Regulation MYLIP WNT7A 23862015 170075 Regulation MYLK EPHB2 21731751 2532405 Regulation MYLK EPHB2 23467882 1879473 Regulation MYLK EPHB2 24255721 2882084 Regulation MYO10 EPHB2 10648571 1255622 Regulation MYO10 EPHB2 23986484 1487117 Regulation MYO10 FOXO1 23799156 2807589 Regulation MYO10 TMOD1 23052974 805265 Regulation MYO10 TMOD1 25520664 967240 Regulation MYO10 TNF 22257771 3160820 Regulation MYO16 EPHB2 10648571 1255621 Regulation MYO16 EPHB2 23986484 1487112 Regulation MYO16 FOXO1 23799156 2807586 Regulation MYO16 TMOD1 23052974 805262 Regulation MYO16 TMOD1 25520664 967237 Regulation MYO16 TNF 22257771 3160819 Regulation MYO19 EPHB2 10648571 1255620 Regulation MYO19 EPHB2 23986484 1487111 Regulation MYO19 FOXO1 23799156 2807584 Regulation MYO19 TMOD1 23052974 805259 Regulation MYO19 TMOD1 25520664 967230 Regulation MYO19 TNF 22257771 3160818 Regulation MYO6 EPHB2 10648571 1255623 Regulation MYO6 EPHB2 23986484 1487118 Regulation MYO6 FOXO1 23799156 2807591 Regulation MYO6 TMOD1 23052974 805268 Regulation MYO6 TMOD1 25520664 967243 Regulation MYO6 TNF 22257771 3160821 Regulation MYOCD EPHB2 23855625 1232450 Regulation MYOCD FOXO1 23554919 2773922 Regulation MYOCD FOXO1 23554919 2774048 Regulation MYOG FOXO1 23799156 2807593 Regulation NAMPT FOXO1 24905194 2977207 Regulation NAMPT TNF 18335040 2386921 Regulation NANOG ABCG2 19107196 2402700 Regulation NANOG CCND1 24043946 2121945 Regulation NANOG HBEGF 22873932 532980 Regulation NANOG HBEGF 22873932 532992 Regulation NANOG ZFP57 24550733 2356301 Regulation NANOG ZFP57 24550733 2356462 Regulation NANOG ZFP57 24550733 2356463 Regulation NANOG ZFP57 24550733 2356667 Regulation NANOS2 EPHB2 11696589 1521581 Regulation NANOS2 TLR7 19139169 1553599 Regulation NANOS2 TNF 22022590 2563989 Regulation NANOS2 TNF 22811738 636690 Regulation NANOS2 TNF 22811738 636692 Regulation NAP1L1 CDKN1C 25071868 803810 Regulation NAP1L2 CDKN1C 24413569 3139328 Regulation NAV1 FOXO1 22400069 2608772 Regulation NAV1 FOXO1 22400069 2608779 Regulation NAV1 FOXO1 22400069 2608780 Regulation NBL1 FAS 25049615 136135 Regulation NBL1 TNF 7520469 1589452 Regulation NBN IFI27 23468519 1812385 Regulation NCEH1 PGC 25610371 872919 Regulation NCF1 HBEGF 22873932 532994 Regulation NCOA2 RARB 15345368 792157 Regulation NCOA3 CCND1 23511556 440356 Regulation NCOA3 EPHB2 21572418 1925879 Regulation NCOA3 EPHB2 21860657 813158 Regulation NCOA3 IFI27 23511556 440357 Regulation NCR2 TLR7 21151495 2485086 Regulation NDC80 WFDC2 23502467 1103020 Regulation NDP FZD4 20512146 1948942 Regulation NDRG1 TLR7 24740015 2953886 Regulation NEB TMOD1 12975349 1297087 Regulation NEB TMOD1 22013379 1222825 Regulation NEDD9 ANAPC10 15144564 277507 Regulation NEDD9 ANAPC10 15144564 277508 Regulation NEDD9 ANAPC10 15144564 277530 Regulation NEDD9 ANAPC10 15144564 277564 Regulation NEDD9 APC 15144564 277559 Regulation NEDD9 BCAR1 20808771 2471838 Regulation NEDD9 CDH1 15144564 277505 Regulation NEDD9 CDH1 15144564 277506 Regulation NEDD9 CDH1 15144564 277529 Regulation NEDD9 CDH1 15144564 277558 Regulation NEDD9 CDH1 21765937 2536534 Regulation NEDD9 DOCK3 25594051 2173946 Regulation NEDD9 FLT3 21552520 2517591 Regulation NEDD9 MYLIP 22869051 2180502 Regulation NEDD9 MYO10 22347397 2595822 Regulation NEDD9 MYO16 22347397 2595821 Regulation NEDD9 MYO19 22347397 2595820 Regulation NEDD9 MYO6 22347397 2595823 Regulation NEDD9 NPY6R 24058594 2848149 Regulation NEDD9 RAC1 25594051 2173947 Regulation NEDD9 RAC2 25594051 2173948 Regulation NEDD9 RAC3 25594051 2173949 Regulation NEDD9 SMAD3 15144564 277509 Regulation NEDD9 SMAD3 15144564 277510 Regulation NEDD9 SMAD3 15144564 277511 Regulation NEDD9 SMAD3 15144564 277523 Regulation NEDD9 SMURF2 20825672 585601 Regulation NEDD9 SMURF2 20825672 585602 Regulation NEDD9 SMURF2 20825672 585603 Regulation NEDD9 SMURF2 20825672 585604 Regulation NEDD9 SMURF2 20825672 585607 Regulation NEDD9 SMURF2 20825672 585608 Regulation NEDD9 SMURF2 20825672 585617 Regulation NEDD9 SMURF2 20825672 585622 Regulation NEDD9 SMURF2 20825672 585623 Regulation NEDD9 STK11 23668926 625615 Regulation NEDD9 WASF2 25594051 2173945 Regulation NEFH PGC 25610371 872920 Regulation NELFCD ALOX5 24832045 176593 Regulation NELFCD FAS 15154605 629967 Regulation NELFCD HRH1 20948178 3079164 Regulation NELFCD JAG1 11238588 1518870 Regulation NELFCD JAG1 18665263 2394122 Regulation NELFCD MUC16 9868597 738714 Regulation NELFCD NES 19406170 1770210 Regulation NELFCD NES 25133189 196818 Regulation NELFCD PLAU 24120085 1667189 Regulation NELFCD STAT4 23990947 2840501 Regulation NELFCD STAT4 24043764 1573625 Regulation NELFCD STAT4 24199193 184775 Regulation NELFCD TCN1 25058148 2992054 Regulation NELFCD TLR7 16365150 1539076 Regulation NELFCD TLR7 19749770 1921401 Regulation NELFCD TLR7 20011519 2433302 Regulation NELFCD TLR7 21253574 3050442 Regulation NELFCD TLR7 21750585 1918478 Regulation NELFCD TLR7 22973560 863687 Regulation NELFCD TLR7 23935651 638108 Regulation NELFCD TLR7 24244362 2879699 Regulation NELFCD TNF 17322989 1606652 Regulation NELFCD TNF 18519801 706201 Regulation NELFCD TNF 20671921 1215939 Regulation NELFCD TNF 23006537 1024590 Regulation NELFCD TNF 23149314 625199 Regulation NELFCD TNF 23657146 3135710 Regulation NELFCD TNF 24465826 2911831 Regulation NELFCD TNF 9151895 1601147 Regulation NELFCD TNFSF10 23497038 1666079 Regulation NELFCD TP63 24023564 638546 Regulation NES ANXA2 23226323 2724123 Regulation NES BRCA2 24013206 1982210 Regulation NES CD47 23591719 3135422 Regulation NES CDK2 19696784 785908 Regulation NES CDK5 20200223 1774858 Regulation NES CDK5 20200223 1774892 Regulation NES CDK5 21346193 1788639 Regulation NES CDK5 21902831 3160715 Regulation NES CXCR5 24528805 1667709 Regulation NES EGF 23468987 2760618 Regulation NES EIF5A 11238447 1267512 Regulation NES F2R 18053121 384485 Regulation NES FGF1 24572070 3169862 Regulation NES FGF2 24572070 3169855 Regulation NES HGF 24572070 3169861 Regulation NES HRES1 21346193 1788642 Regulation NES MAPK8 22496975 1687894 Regulation NES MSH4 20185565 2052449 Regulation NES MSH5 20185565 2052450 Regulation NES MYC 21304179 2174837 Regulation NES MYC 21304179 2174838 Regulation NES MYLIP 23016664 387852 Regulation NES MYLIP 23016664 387856 Regulation NES NPAS4 24887558 3169992 Regulation NES NR0B1 24013206 1982211 Regulation NES NRG1 23938193 510181 Regulation NES NRG2 23938193 510182 Regulation NES NRG3 23938193 510183 Regulation NES NRG4 23938193 510180 Regulation NES PARP10 22992334 533097 Regulation NES PPP1R3A 24979747 2985664 Regulation NES PPP1R3A 24979747 2985681 Regulation NES RDX 21179535 2488451 Regulation NES SEC14L2 21060813 3049350 Regulation NES SETD2 25088159 412640 Regulation NES SETD2 25088159 412643 Regulation NES SKP1 23226372 2724392 Regulation NES SKP2 23226372 2724393 Regulation NES SMAD4 24625091 272353 Regulation NES SMAD4 24625091 272356 Regulation NES VEGFA 25088159 412639 Regulation NES XPO1 12045187 1283701 Regulation NES XPO1 17067381 3116365 Regulation NES XPO1 17726514 2377632 Regulation NES XPO1 17726514 2377635 Regulation NES XPO1 17726514 2377636 Regulation NES XPO1 19564402 1367415 Regulation NES XPO1 19606211 2421545 Regulation NES XPO1 19606211 2421552 Regulation NES XPO1 19750013 2426367 Regulation NES XPO1 19750013 2426369 Regulation NES XPO1 21034499 1026045 Regulation NES XPO1 21060813 3049358 Regulation NES XPO1 21109527 2059057 Regulation NES XPO1 21268017 808245 Regulation NES XPO1 21695276 2530340 Regulation NES XPO1 21736733 1697575 Regulation NES XPO1 21871131 1863057 Regulation NES XPO1 21871131 1863058 Regulation NES XPO1 22334672 1201175 Regulation NES XPO1 22334672 1201180 Regulation NES XPO1 22334672 1201187 Regulation NES XPO1 22815488 1204064 Regulation NES XPO1 22815488 1204066 Regulation NES XPO1 22815488 1204068 Regulation NES XPO1 22815488 1204070 Regulation NES XPO1 23181164 654373 Regulation NES XPO1 23297360 1033889 Regulation NES XPO1 23383123 2748039 Regulation NES XPO1 23951221 2833819 Regulation NES XPO1 23951221 2833840 Regulation NES XPO1 23965528 3223460 Regulation NES XPO1 24959884 2983277 Regulation NES XPO1 25072814 2993033 Regulation NES XPO1 25233087 2301441 Regulation NES XPO4 21109527 2059060 Regulation NES XPO4 24959884 2983280 Regulation NES XPO5 21109527 2059059 Regulation NES XPO5 24959884 2983279 Regulation NES XPO6 21109527 2059061 Regulation NES XPO6 24959884 2983281 Regulation NES XPO7 21109527 2059058 Regulation NES XPO7 24959884 2983278 Regulation NET1 TNF 16552434 427213 Regulation NEUROD1 EPHB2 21203386 2489681 Regulation NEUROD1 EPHB2 23670594 1106740 Regulation NEUROD1 EPHB2 24465772 2911735 Regulation NEUROD1 EPHB2 24465772 2911740 Regulation NEUROD1 HRH1 25112718 1843237 Regulation NEUROD1 IFI27 20810788 1782475 Regulation NEUROD1 IFI27 21566658 547268 Regulation NEUROD1 IL6R 19239705 324892 Regulation NEUROD1 MAP2K6 21203386 2489687 Regulation NEUROD1 NGFR 23660869 3135745 Regulation NEUROD1 NGFR 23660869 3135753 Regulation NEUROD1 NR2F1 23472160 2764309 Regulation NEUROD1 TF 2981233 1424752 Regulation NEUROD1 TMOD1 23638401 2236524 Regulation NEUROD1 TMOD1 23638401 2236533 Regulation NEUROD1 WNT7A 25170755 3003868 Regulation NEUROD1 ZFP57 22735705 2079263 Regulation NEUROD2 EPHB2 21203386 2489689 Regulation NEUROD2 EPHB2 23670594 1106759 Regulation NEUROD2 EPHB2 24465772 2911736 Regulation NEUROD2 EPHB2 24465772 2911741 Regulation NEUROD2 HRH1 25112718 1843238 Regulation NEUROD2 IFI27 20810788 1782477 Regulation NEUROD2 IFI27 21566658 547269 Regulation NEUROD2 IL6R 19239705 324894 Regulation NEUROD2 MAP2K6 21203386 2489695 Regulation NEUROD2 NGFR 23660869 3135747 Regulation NEUROD2 NGFR 23660869 3135755 Regulation NEUROD2 NR2F1 23472160 2764310 Regulation NEUROD2 TF 2981233 1424753 Regulation NEUROD2 TMOD1 23638401 2236525 Regulation NEUROD2 TMOD1 23638401 2236534 Regulation NEUROD2 WNT7A 25170755 3003870 Regulation NEUROD2 ZFP57 22735705 2079281 Regulation NEUROD4 EPHB2 21203386 2489665 Regulation NEUROD4 EPHB2 23670594 1106702 Regulation NEUROD4 EPHB2 24465772 2911733 Regulation NEUROD4 EPHB2 24465772 2911738 Regulation NEUROD4 HRH1 25112718 1843235 Regulation NEUROD4 IFI27 20810788 1782471 Regulation NEUROD4 IFI27 21566658 547266 Regulation NEUROD4 IL6R 19239705 324888 Regulation NEUROD4 MAP2K6 21203386 2489671 Regulation NEUROD4 NGFR 23660869 3135741 Regulation NEUROD4 NGFR 23660869 3135749 Regulation NEUROD4 NR2F1 23472160 2764307 Regulation NEUROD4 TF 2981233 1424750 Regulation NEUROD4 TMOD1 23638401 2236522 Regulation NEUROD4 TMOD1 23638401 2236531 Regulation NEUROD4 WNT7A 25170755 3003864 Regulation NEUROD4 ZFP57 22735705 2079227 Regulation NEUROD6 EPHB2 21203386 2489673 Regulation NEUROD6 EPHB2 23670594 1106721 Regulation NEUROD6 EPHB2 24465772 2911734 Regulation NEUROD6 EPHB2 24465772 2911739 Regulation NEUROD6 HRH1 25112718 1843236 Regulation NEUROD6 IFI27 20810788 1782473 Regulation NEUROD6 IFI27 21566658 547267 Regulation NEUROD6 IL6R 19239705 324890 Regulation NEUROD6 MAP2K6 21203386 2489679 Regulation NEUROD6 NGFR 23660869 3135743 Regulation NEUROD6 NGFR 23660869 3135751 Regulation NEUROD6 NR2F1 23472160 2764308 Regulation NEUROD6 TF 2981233 1424751 Regulation NEUROD6 TMOD1 23638401 2236523 Regulation NEUROD6 TMOD1 23638401 2236532 Regulation NEUROD6 WNT7A 25170755 3003866 Regulation NEUROD6 ZFP57 22735705 2079245 Regulation NF1 CLU 21281507 356985 Regulation NFASC ANK1 9660878 1468379 Regulation NFASC ANK2 9660878 1468380 Regulation NFASC ANK3 9660878 1468381 Regulation NFAT5 EPHB2 25152734 965842 Regulation NFAT5 TLR7 22312110 1567211 Regulation NFAT5 TLR7 23867654 839178 Regulation NFATC1 EFNB1 22403721 2609230 Regulation NFATC1 FHL1 19075112 1362573 Regulation NFATC1 FHL1 19075112 1362574 Regulation NFATC1 FHL1 19075112 1362576 Regulation NFATC1 RCAN1 19860902 526179 Regulation NFATC1 RCAN1 21464221 1563204 Regulation NFATC1 TLR7 21861861 123743 Regulation NFATC1 TNF 20482767 118985 Regulation NFATC1 TNF 23082080 816037 Regulation NFATC3 TNF 23690827 637408 Regulation NFE2 MMP28 23613970 2782946 Regulation NFE2L2 ALDH2 21249230 2494453 Regulation NFE2L2 EPHB2 21270272 717454 Regulation NFE2L2 EPHB2 21931870 2555203 Regulation NFE2L2 EPHB2 23710636 220516 Regulation NFE2L2 F2R 22541814 125639 Regulation NFIC MATN2 24895400 1487946 Regulation NFKB1 CCND1 23145063 2715548 Regulation NFKB1 EPHB2 23762330 2803048 Regulation NFKB1 IL1B 23323936 239525 Regulation NFKB1 MAP2K6 23675062 1064473 Regulation NFKB1 MMP28 25099178 2995546 Regulation NFKB1 MMP7 25099178 2995561 Regulation NFKB1 TLR7 24454965 2910534 Regulation NFKB1 TM4SF19 25344917 2206270 Regulation NFKB1 TNF 11097206 702063 Regulation NFKB1 TNF 17032459 319207 Regulation NFKB1 TNF 17868448 392117 Regulation NFKB1 TNF 19036161 1238126 Regulation NFKB1 TNF 21539730 1626349 Regulation NFKB1 TNF 2193094 1565442 Regulation NFKB1 TNF 22654792 875819 Regulation NFKB1 TNF 22654792 875820 Regulation NFKB1 TNF 22787387 742505 Regulation NFKB1 TNF 22870920 239402 Regulation NFKB1 TNF 22911724 2675984 Regulation NFKB1 TNF 22911724 2675993 Regulation NFKB1 TNF 23576877 1628499 Regulation NFKB1 TNF 23576877 1628503 Regulation NFKB1 TNF 23593011 2345224 Regulation NFKB1 TNF 24710489 618877 Regulation NFKB1 TNF 7561697 1590670 Regulation NFKB1 TNF 8655581 1451891 Regulation NFKB1 TNF 8698809 1452485 Regulation NFKB1 TNF PMC2750202 450204 Regulation NGF IL1B 16594997 1654851 Regulation NGF NGFR 3005338 1425036 Regulation NGF NGFR 6290502 1430894 Regulation NGFR FYN 22880054 2673833 Regulation NGFR FYN 22880054 2674067 Regulation NGFR MLST8 25221943 3007226 Regulation NGFR MTOR 25221943 3007228 Regulation NGFR NGF 1348250 1297637 Regulation NGFR NGF 1618900 1324474 Regulation NGFR NGF 1671048 1329979 Regulation NGFR NGF 1671048 1329992 Regulation NGFR NGF 1671048 1329996 Regulation NGFR NGF 7559764 1437131 Regulation NGFR NTRK1 7540615 1436826 Regulation NGFR RPTOR 25221943 3007227 Regulation NGFR SYK 22880054 2673832 Regulation NGFR SYK 22880054 2674066 Regulation NGFR TNF 21519548 85482 Regulation NGFR TNF 21519548 85491 Regulation NGFR TNF 21519548 85493 Regulation NGFR TNFRSF1B 8676061 1597704 Regulation NLRP12 TNF 24273542 909954 Regulation NLRP3 TLR7 21533069 3051619 Regulation NLRP3 TLR7 23666718 780762 Regulation NLRP3 TLR7 24273750 864455 Regulation NLRP3 TLR7 24966466 1759768 Regulation NM EPHB2 24842369 1576284 Regulation NM EPHB2 24842369 1576305 Regulation NM EPHB2 24842369 1576321 Regulation NM ITGB2 11457896 1519998 Regulation NM ITGB2 11457896 1519999 Regulation NM PECAM1 12417630 1525143 Regulation NM PECAM1 12417630 1525144 Regulation NM TNF 11097214 702133 Regulation NM TNF 18472822 1741850 Regulation NM TNF 18475491 1744039 Regulation NM TNF 18475491 1744040 Regulation NM TNF 18475579 1744401 Regulation NM TNF 22991570 815627 Regulation NM TNF 24223056 824056 Regulation NM TNF 24385881 3155775 Regulation NME1 IFI27 19123928 1994644 Regulation NMNAT2 TAP1 25271157 1211030 Regulation NMNAT2 TAP2 25271157 1211031 Regulation NNMT IL6 19216803 1503538 Regulation NNMT STAT3 19216803 1503537 Regulation NOD1 TLR7 24676425 3066567 Regulation NOD1 TNF 19356238 113110 Regulation NOD2 TLR7 24676425 3066568 Regulation NOD2 TNF 19356238 113111 Regulation NOD2 TNF 24886810 1127306 Regulation NONO EPHB2 21368873 550845 Regulation NOS1 ARSA 22837307 724033 Regulation NOS1 ARSA 22837307 724034 Regulation NOS1 BLVRA 25206501 2004856 Regulation NOS1 BLVRA 25206501 2004863 Regulation NOS1 EPHB2 19343212 3043663 Regulation NOS1 EPHB2 19343212 3043664 Regulation NOS1 EPHB2 19343212 3043665 Regulation NOS1 EPHB2 19343212 3043680 Regulation NOS1 EPHB2 19343212 3043699 Regulation NOS1 MAP2K6 15899045 103738 Regulation NOS1 MAP2K6 19343212 3043686 Regulation NOS1 OSR1 25206429 2004426 Regulation NOS1 TNF 18475707 1745489 Regulation NOS1 TNF 19118493 651017 Regulation NOS1 TNF 23209478 1703313 Regulation NOS2 BLVRA 25206501 2004857 Regulation NOS2 BLVRA 25206501 2004864 Regulation NOS2 EPHB2 20396387 1214739 Regulation NOS2 EPHB2 23946691 1716146 Regulation NOS2 EPHB2 25079440 1128787 Regulation NOS2 FOXO1 19584310 710418 Regulation NOS2 FOXO1 19584310 710424 Regulation NOS2 IL1B 11200365 1737637 Regulation NOS2 IL1B 11200365 1737651 Regulation NOS2 PTGER2 22159280 83843 Regulation NOS2 TLR7 20385024 290784 Regulation NOS2 TLR7 23637937 2786731 Regulation NOS2 TLR7 23690823 637357 Regulation NOS2 TLR7 24479442 1667584 Regulation NOS2 TLR7 24847328 912740 Regulation NOS2 TNF 14657222 1529931 Regulation NOS2 TNF 16606437 658633 Regulation NOS2 TNF 18475707 1745490 Regulation NOS2 TNF 19118493 651023 Regulation NOS2 TNF 19557162 3044211 Regulation NOS2 TNF 20828402 1657156 Regulation NOS2 TNF 22132330 1155370 Regulation NOS2 TNF 22506619 451408 Regulation NOS2 TNF 22570765 1680691 Regulation NOS2 TNF 22654792 875821 Regulation NOS2 TNF 22745717 2655864 Regulation NOS2 TNF 23346188 817062 Regulation NOS2 TNF 23365490 1751433 Regulation NOS2 TNF 23531541 1103888 Regulation NOS2 TNF 23984387 183522 Regulation NOS2 TNF 24039983 2845183 Regulation NOS2 TNF 24747164 18912 Regulation NOS2 TNF 25426114 915249 Regulation NOS2 TNF 7530762 1589951 Regulation NOS2 TNF 9104810 1600626 Regulation NOS3 ALDH2 22606372 2116814 Regulation NOS3 ANGPT1 16584574 279146 Regulation NOS3 BLVRA 25206501 2004858 Regulation NOS3 BLVRA 25206501 2004865 Regulation NOS3 CAPN8 23533715 1080953 Regulation NOS3 CAPN8 24886224 511558 Regulation NOS3 EPHB2 18382618 831314 Regulation NOS3 EPHB2 21937726 1795108 Regulation NOS3 EPHB2 25000310 216079 Regulation NOS3 EPHB2 25460732 3094738 Regulation NOS3 FOXO1 19584310 710419 Regulation NOS3 IGFBP1 22357965 721623 Regulation NOS3 PECAM1 23785479 2806390 Regulation NOS3 PGC 22802954 2663778 Regulation NOS3 PGC 23056347 2701295 Regulation NOS3 STK39 22916065 1613804 Regulation NOS3 TNF 18475707 1745491 Regulation NOS3 TNF 19118493 651001 Regulation NOS3 TNF 24381514 3155629 Regulation NOTCH1 F2R 22952817 2684152 Regulation NOTCH1 FOXA1 24512546 271508 Regulation NOTCH1 FOXO1 21804540 1961586 Regulation NOTCH1 FOXO1 21804540 1961620 Regulation NOTCH1 HES2 22074495 1864082 Regulation NOTCH1 JAG1 18194540 242224 Regulation NOTCH1 JAG1 20016694 1160888 Regulation NOTCH1 JAG1 23092791 1619995 Regulation NOTCH1 JAG1 23901284 2121527 Regulation NOTCH1 JAG1 24563863 187177 Regulation NOTCH1 JAG1 24708907 6083 Regulation NOTCH1 MAMLD1 24391519 2355279 Regulation NOTCH1 NRARP 19197356 2307254 Regulation NOTCH1 PLAU 22004682 1863773 Regulation NOTCH1 PLAU 22004682 1863799 Regulation NOTCH1 PLAU 22004682 1863809 Regulation NOTCH1 RORC 22430492 1567852 Regulation NOTCH1 TNF 20011512 2433205 Regulation NOTCH1 TNF 20011512 2433228 Regulation NOTCH1 TNF 20814569 2473430 Regulation NOTCH1 TNF 20814569 2473431 Regulation NOTCH1 TNF 20814569 2473447 Regulation NOTCH1 TNF 20814569 2473462 Regulation NOTCH1 TNF 20814569 2473464 Regulation NOTCH1 TNF 20814569 2473465 Regulation NOTCH1 TNF 22190977 633833 Regulation NOTCH2 FOXA1 24512546 271509 Regulation NOTCH2 FOXO1 21804540 1961621 Regulation NOTCH2 HES2 22074495 1864091 Regulation NOTCH2 IGFBP1 25397403 3027152 Regulation NOTCH2 JAG1 20016694 1160889 Regulation NOTCH2 JAG1 23092791 1619996 Regulation NOTCH2 JAG1 23901284 2121530 Regulation NOTCH2 JAG1 24708907 6084 Regulation NOTCH2 MAMLD1 24391519 2355280 Regulation NOTCH2 NRARP 19197356 2307255 Regulation NOTCH2 PLAU 22004682 1863810 Regulation NOTCH2 RORC 22430492 1567854 Regulation NOTCH2 TNF 20011512 2433206 Regulation NOTCH2 TNF 20011512 2433222 Regulation NOTCH2 TNF 20011512 2433229 Regulation NOTCH2 TNF 22190977 633834 Regulation NOTCH3 EPHB2 25164432 1484771 Regulation NOTCH3 FOXA1 24512546 271510 Regulation NOTCH3 FOXO1 21804540 1961622 Regulation NOTCH3 HES2 22074495 1864100 Regulation NOTCH3 JAG1 20016694 1160890 Regulation NOTCH3 JAG1 20953350 2174590 Regulation NOTCH3 JAG1 23092791 1619997 Regulation NOTCH3 JAG1 23901284 2121533 Regulation NOTCH3 JAG1 24708907 6085 Regulation NOTCH3 MAMLD1 24391519 2355281 Regulation NOTCH3 NRARP 19197356 2307256 Regulation NOTCH3 PLAU 22004682 1863811 Regulation NOTCH3 RORC 22430492 1567856 Regulation NOTCH3 TNF 20011512 2433207 Regulation NOTCH3 TNF 20011512 2433230 Regulation NOTCH3 TNF 22190977 633835 Regulation NOTCH4 FOXA1 24512546 271511 Regulation NOTCH4 FOXO1 21804540 1961623 Regulation NOTCH4 HES2 22074495 1864109 Regulation NOTCH4 JAG1 20016694 1160891 Regulation NOTCH4 JAG1 23092791 1619998 Regulation NOTCH4 JAG1 23901284 2121536 Regulation NOTCH4 JAG1 24708907 6086 Regulation NOTCH4 MAMLD1 24391519 2355282 Regulation NOTCH4 NRARP 19197356 2307257 Regulation NOTCH4 PLAU 22004682 1863812 Regulation NOTCH4 RORC 22430492 1567858 Regulation NOTCH4 TNF 20011512 2433208 Regulation NOTCH4 TNF 20011512 2433231 Regulation NOTCH4 TNF 22190977 633836 Regulation NOTO FOXA1 23383217 2749521 Regulation NOV FOXO1 23705021 2797497 Regulation NOV FOXO1 23705021 2797498 Regulation NOV FOXO1 23705021 2797499 Regulation NOV TNF 24722330 2951162 Regulation NOX1 ALOX5 17625512 1902342 Regulation NOX1 EPHB2 22559742 398603 Regulation NOX1 EPHB2 23434665 1101996 Regulation NOX1 EPHB2 24132149 1113500 Regulation NOX1 TLR7 24823882 1126708 Regulation NOX1 TNF 20500811 3110373 Regulation NOX1 TNF 21670490 2176165 Regulation NOX1 TNF 21966220 3209162 Regulation NOX1 TP63 9064349 1600441 Regulation NOX3 ALOX5 17625512 1902343 Regulation NOX3 EPHB2 22559742 398604 Regulation NOX3 EPHB2 23434665 1101998 Regulation NOX3 TLR7 24823882 1126718 Regulation NOX3 TNF 20500811 3110374 Regulation NOX3 TNF 21966220 3209163 Regulation NOX3 TP63 9064349 1600443 Regulation NOX4 ALOX5 17625512 1902344 Regulation NOX4 EPHB2 22140508 2574865 Regulation NOX4 EPHB2 22559742 398605 Regulation NOX4 EPHB2 23434665 1102001 Regulation NOX4 TLR7 24823882 1126728 Regulation NOX4 TNF 20500811 3110375 Regulation NOX4 TNF 21966220 3209164 Regulation NOX4 TP63 9064349 1600445 Regulation NOX5 ALOX5 17625512 1902337 Regulation NOX5 EPHB2 22559742 398602 Regulation NOX5 EPHB2 23434665 1101988 Regulation NOX5 TLR7 24823882 1126698 Regulation NOX5 TNF 20500811 3110372 Regulation NOX5 TNF 21966220 3209158 Regulation NOX5 TP63 9064349 1600439 Regulation NPAS2 RORC 18454201 2305296 Regulation NPNT GALNT7 19844573 2428919 Regulation NPNT MIR378A 25006962 2987327 Regulation NPNT MYLIP 24130780 2866933 Regulation NPNT TAS2R38 22518348 1692905 Regulation NPPA TNF 24369440 1755932 Regulation NPR1 TNF 24369440 1755933 Regulation NPR1 TNF 24369440 1755937 Regulation NPS CD14 23803652 1108026 Regulation NPS LBP 23803652 1108027 Regulation NPS TNF 24369440 1755936 Regulation NPTX1 TNF 12186649 994878 Regulation NPTX2 TNF 12186649 994880 Regulation NPY FOXO1 22876196 2337363 Regulation NPY FOXO1 22876196 2337379 Regulation NQO1 TNF 22866165 1239690 Regulation NQO1 TNF 22866165 1239691 Regulation NR0B1 EPHB2 23894528 2825184 Regulation NR2F1 NEUROD1 23472160 2764292 Regulation NR2F1 NEUROD2 23472160 2764293 Regulation NR2F1 NEUROD4 23472160 2764290 Regulation NR2F1 NEUROD6 23472160 2764291 Regulation NR2F1 SUZ12 23666625 2088340 Regulation NR3C2 CTGF 15608389 1634458 Regulation NR3C2 ITGAL 2952751 1579187 Regulation NR3C2 TLR7 24705920 2949322 Regulation NR4A2 EPHB2 19522012 3170498 Regulation NR4A2 EPHB2 19522012 3170539 Regulation NRARP MYLIP 22916024 2337818 Regulation NRAS DGKI 25233099 3008243 Regulation NRAS DGKI 25233099 3008250 Regulation NRAS EPHB2 17449939 1634821 Regulation NRAS EPHB2 18597688 251138 Regulation NRAS EPHB2 18629230 1212721 Regulation NRAS EPHB2 25003010 3092924 Regulation NRAS FOXO1 20375467 27086 Regulation NRAS FOXO1 23306151 1100411 Regulation NRAS FOXO1 24265619 962931 Regulation NRAS LGALS7B 23530091 2182842 Regulation NRAS LIPG 17967061 3039971 Regulation NRAS MAP2K6 18629230 1212727 Regulation NRAS STK39 24849659 2972613 Regulation NRAS TNF 25526565 1136163 Regulation NRCAM EFNB1 24023801 2843634 Regulation NRCAM EPHB2 24023801 2843638 Regulation NRCAM NFASC 21382554 2010199 Regulation NRD1 PGC 24492630 1940588 Regulation NRD1 PGC 24492630 1940596 Regulation NRD1 PGC 24492630 1940610 Regulation NRF1 EPHB2 23710636 220518 Regulation NRF1 PGC 24098634 2858242 Regulation NRIP1 TLR7 21193034 158634 Regulation NRXN3 FOXQ1 23383267 2749802 Regulation NRXN3 FOXQ1 23383267 2749803 Regulation NRXN3 FOXQ1 23383267 2749804 Regulation NRXN3 FOXQ1 23383267 2749805 Regulation NRXN3 FOXQ1 23383267 2749806 Regulation NRXN3 FOXQ1 23383267 2749808 Regulation NRXN3 FOXQ1 23383267 2749809 Regulation NRXN3 FOXQ1 23383267 2749810 Regulation NRXN3 FOXQ1 23383267 2749814 Regulation NT5E BMP2 24018651 1675559 Regulation NT5E CD28 24493796 1574730 Regulation NT5E NGF 17653301 3360 Regulation NT5E SETD2 18404475 3087789 Regulation NT5E SETD2 18404475 3087791 Regulation NT5E SP1 23118504 1225316 Regulation NT5E TNF 24133572 2867756 Regulation NT5E TNF 24133572 2867757 Regulation NTF3 RAB31 25295627 1766538 Regulation NTF3 TNF 19695094 116629 Regulation NTF4 RAB31 25295627 1766565 Regulation NTF4 TNF 19695094 116630 Regulation NTN1 EPHB2 22046354 2566901 Regulation NTN1 UNC5B 21813473 1023467 Regulation NTRK1 CTGF 22586581 722783 Regulation NTRK1 CTGF 22586581 722794 Regulation NTRK1 CTGF 22586581 722795 Regulation NTRK1 NGFR 22236693 1652116 Regulation NTRK1 NGFR 7540615 1436827 Regulation NTRK2 NT5E 24758840 619706 Regulation NTRK2 TNF 21958434 1659850 Regulation NTRK3 NT5E 24758840 619710 Regulation NUP107 NES 9151683 1460333 Regulation NUP133 NES 9151683 1460327 Regulation NUP153 INPP4B 25126743 2998013 Regulation NUP153 NES 9151683 1460336 Regulation NUP155 NES 9151683 1460337 Regulation NUP160 NES 9151683 1460328 Regulation NUP188 NES 9151683 1460326 Regulation NUP205 NES 9151683 1460329 Regulation NUP210 INPP4B 25126743 2998012 Regulation NUP210 NES 9151683 1460335 Regulation NUP214 INPP4B 25126743 2998014 Regulation NUP214 NES 9151683 1460338 Regulation NUP35 NES 9151683 1460332 Regulation NUP37 NES 9151683 1460334 Regulation NUP43 FAS 16818723 1330947 Regulation NUP43 MIP 17233909 351843 Regulation NUP43 NES 9151683 1460330 Regulation NUP50 EPHB2 22028962 1686702 Regulation NUP50 NES 9151683 1460339 Regulation NUP54 NES 9151683 1460325 Regulation NUP62 INPP4B 25126743 2998015 Regulation NUP62 NES 9151683 1460340 Regulation NUP85 NES 9151683 1460343 Regulation NUP88 NES 9151683 1460341 Regulation NUP93 NES 9151683 1460331 Regulation NUP98 NES 9151683 1460342 Regulation OASL IFN1@ 23874199 3063148 Regulation OATP1 PDZK1 24728453 2952056 Regulation OCLN ANGPT1 23894369 2824424 Regulation OCLN ANGPT1 23894369 2824433 Regulation OCLN C12orf75 9015310 1459009 Regulation OCLN CAPN8 21737691 1791757 Regulation OCLN MMP7 20442866 3046770 Regulation OCLN TNF 23924897 1817688 Regulation OCLN TNF 24259385 1029580 Regulation OCLN TNF 24992685 2986599 Regulation OLFM4 CASP3 22471589 1230542 Regulation OLFM4 NOTCH1 PMC4212306 3206500 Regulation OLFM4 NOTCH2 PMC4212306 3206501 Regulation OLFM4 NOTCH3 PMC4212306 3206502 Regulation OLFM4 NOTCH4 PMC4212306 3206503 Regulation OLFM4 PIK3CA 25364714 861621 Regulation OLFM4 PIK3R1 25364714 861622 Regulation OLFM4 SMARCA4 25010414 2360361 Regulation OLR1 TNF 24217965 1606828 Regulation OLR1 TNF 25250731 3009901 Regulation OLR1 TNFSF10 24466325 2914332 Regulation OPA1 ALOX5 23991239 2372082 Regulation OPA1 EPHB2 21789185 2538091 Regulation OPA1 IL1B 11132773 1737401 Regulation OPA1 TLR7 15804356 3104869 Regulation OPA1 TNF 11132773 1737400 Regulation OPA1 TNF 24963279 842233 Regulation OPN3 NR2F1 24058409 2847297 Regulation OPN4 NR2F1 24058409 2847298 Regulation OPN5 NR2F1 24058409 2847299 Regulation OSM ADAMTS1 20645923 147958 Regulation OSR1 ARSD 24795851 2236863 Regulation OSR1 CDH1 25226030 3007623 Regulation OSR1 COMT 19228412 143279 Regulation OSR1 JUN 24349499 2898363 Regulation OSR1 SETD2 22510688 1933971 Regulation OSR1 SOD2 25226030 3007574 Regulation OSR1 SOD2 25226030 3007641 Regulation OSR1 WNK1 24393035 152291 Regulation OSR1 WNK2 24393035 152292 Regulation OSR1 WNK3 24393035 152293 Regulation OSR1 WNK4 24393035 152294 Regulation OXA1L CCND1 25289101 2169777 Regulation OXA1L FAS 24691448 2947766 Regulation OXA1L RCAN1 19603121 1832695 Regulation OXA1L WNT7A 23862015 170015 Regulation OXA1L WNT7A 23862015 170016 Regulation OXA1L WNT7A 23862015 170017 Regulation OXA1L WNT7A 23862015 170035 Regulation OXA1L WNT7A 23862015 170078 Regulation OXT OXTR 23815867 1769915 Regulation OXTR CSH1 22958877 1161596 Regulation OXTR ESR1 21811473 972199 Regulation OXTR ESR1 23050969 89632 Regulation OXTR GH1 22958877 1161597 Regulation OXTR IL13 20670427 3110888 Regulation OXTR IL13 20670427 3110889 Regulation OXTR IL1A PMC2442803 1049670 Regulation OXTR PPP5C 24334513 1685263 Regulation OXTR PPP5C 24334513 1685264 Regulation P2RX1 GPR115 21172341 810230 Regulation P2RX1 GPR132 21172341 810219 Regulation P2RX1 GPR87 21172341 810299 Regulation P2RY1 IL1B 18553155 3090118 Regulation PABPC1 LAMB3 22160594 1798637 Regulation PABPC1 RAB31 18060067 2381250 Regulation PADI3 DEFA1B 23028349 2338285 Regulation PAF1 ARSA 18475637 1745105 Regulation PAF1 LPCAT1 25415055 177558 Regulation PAF1 TNF 3119758 1580157 Regulation PAF1 TNF 3119758 1580158 Regulation PAF1 TNF 3119758 1580180 Regulation PAH STK39 21533110 2514469 Regulation PAIP1 LAMB3 22160594 1798628 Regulation PAIP1 RAB31 18060067 2381166 Regulation PAK1 ARSA 23146664 154200 Regulation PAK1 EPHB2 23497290 1867539 Regulation PAK1 TNF 19298660 352677 Regulation PAK1 TNF 19298660 352774 Regulation PAK1 TNF 19298660 352778 Regulation PAK2 EPHB2 23497290 1867540 Regulation PAK2 SLC6A2 23864709 1817036 Regulation PAK2 SLC6A2 23864709 1817040 Regulation PAK2 SLC6A2 23864709 1817044 Regulation PAK3 EPHB2 23497290 1867541 Regulation PAK4 EPHB2 23497290 1867536 Regulation PAK6 EPHB2 23497290 1867537 Regulation PAK7 EPHB2 23497290 1867535 Regulation PALLD EPHB2 22216253 2585047 Regulation PALLD EPHB2 22216253 2585075 Regulation PALLD MAP2K6 22216253 2585053 Regulation PALLD MAP2K6 22216253 2585081 Regulation PAM CD14 24349012 2896578 Regulation PAPPA TNF 22997483 1750585 Regulation PAPPA TNF 22997483 1750586 Regulation PARK10 PGC 22916173 2680151 Regulation PARK11 PGC 22916173 2680152 Regulation PARK12 PGC 22916173 2680153 Regulation PARK16 PGC 22916173 2680154 Regulation PARK2 PGC 22916173 2680155 Regulation PARK3 PGC 22916173 2680156 Regulation PARK7 EPHB2 20386724 2271424 Regulation PARK7 PGC 22916173 2680150 Regulation PARK7 RAB31 23892275 18193 Regulation PARK7 RAB31 23892275 18220 Regulation PARK7 TNF 24963279 842163 Regulation PARP1 CAPN8 22666585 2009600 Regulation PARP1 CAPN8 22666585 2009635 Regulation PARP1 EPHB2 24145797 786323 Regulation PARP1 FAS 9730899 1603687 Regulation PARP1 IFI27 18412984 323106 Regulation PARP1 LBP 24595452 2931323 Regulation PARP1 PECAM1 10725328 1256590 Regulation PARP1 TLR7 25118589 1945101 Regulation PARP1 TNF 15642133 102145 Regulation PARP1 TNF 23760205 605919 Regulation PARP1 TNF 24363881 1764622 Regulation PARP1 TNFSF10 17718901 1645708 Regulation PARP1 TNFSF10 25191654 861474 Regulation PARP10 FAS 9730899 1603682 Regulation PARP10 NES 22992334 533096 Regulation PARP10 TNF 15642133 102135 Regulation PARP10 TNFSF10 17718901 1645703 Regulation PARP10 TNFSF10 25191654 861469 Regulation PARP11 FAS 9730899 1603655 Regulation PARP11 TNF 15642133 102128 Regulation PARP11 TNFSF10 17718901 1645697 Regulation PARP11 TNFSF10 25191654 861466 Regulation PARP12 FAS 9730899 1603680 Regulation PARP12 TNF 15642133 102130 Regulation PARP12 TNFSF10 17718901 1645701 Regulation PARP12 TNFSF10 25191654 861467 Regulation PARP14 FAS 9730899 1603693 Regulation PARP14 TNF 15642133 102153 Regulation PARP14 TNFSF10 17718901 1645712 Regulation PARP14 TNFSF10 25191654 861478 Regulation PARP15 FAS 9730899 1603685 Regulation PARP15 TNF 15642133 102141 Regulation PARP15 TNFSF10 17718901 1645706 Regulation PARP15 TNFSF10 25191654 861472 Regulation PARP16 FAS 9730899 1603683 Regulation PARP16 TNF 15642133 102137 Regulation PARP16 TNFSF10 17718901 1645704 Regulation PARP16 TNFSF10 25191654 861470 Regulation PARP2 FAS 9730899 1603689 Regulation PARP2 TNF 15642133 102149 Regulation PARP2 TNFSF10 17718901 1645710 Regulation PARP2 TNFSF10 25191654 861476 Regulation PARP3 FAS 9730899 1603692 Regulation PARP3 TNF 15642133 102151 Regulation PARP3 TNFSF10 17718901 1645711 Regulation PARP3 TNFSF10 25191654 861477 Regulation PARP4 FAS 9730899 1603688 Regulation PARP4 TNF 15642133 102147 Regulation PARP4 TNFSF10 17718901 1645709 Regulation PARP4 TNFSF10 25191654 861475 Regulation PARP6 FAS 9730899 1603686 Regulation PARP6 TNF 15642133 102143 Regulation PARP6 TNFSF10 17718901 1645707 Regulation PARP6 TNFSF10 25191654 861473 Regulation PARP8 FAS 9730899 1603684 Regulation PARP8 TNF 15642133 102139 Regulation PARP8 TNFSF10 17718901 1645705 Regulation PARP8 TNFSF10 25191654 861471 Regulation PARP9 FAS 9730899 1603681 Regulation PARP9 TNF 15642133 102132 Regulation PARP9 TNFSF10 17718901 1645702 Regulation PARP9 TNFSF10 25191654 861468 Regulation PARVA EPHB2 15353548 1311970 Regulation PARVA EPHB2 15353548 1311979 Regulation PAX3 FOXO1 23799156 2807595 Regulation PAX6 CCND1 24454925 2910388 Regulation PAX7 TNF 20814569 2473463 Regulation PAX9 MSX1 24160254 345744 Regulation PCBD1 TGM2 20363864 1499204 Regulation PCBD1 TNF 24406986 3139225 Regulation PCDH19 CTCF 22210889 2071211 Regulation PCDH19 CTCF 22988450 882914 Regulation PCDH19 REST 20385576 2052918 Regulation PCDH19 SMCHD1 24818964 2968672 Regulation PCDH19 ZNF10 24818964 2965250 Regulation PCDH19 ZNF100 24818964 2965251 Regulation PCDH19 ZNF101 24818964 2965252 Regulation PCDH19 ZNF106 24818964 2965253 Regulation PCDH19 ZNF107 24818964 2965254 Regulation PCDH19 ZNF112 24818964 2965255 Regulation PCDH19 ZNF114 24818964 2965256 Regulation PCDH19 ZNF117 24818964 2965257 Regulation PCDH19 ZNF12 24818964 2965258 Regulation PCDH19 ZNF121 24818964 2965259 Regulation PCDH19 ZNF124 24818964 2965260 Regulation PCDH19 ZNF131 24818964 2965261 Regulation PCDH19 ZNF132 24818964 2965262 Regulation PCDH19 ZNF133 24818964 2965263 Regulation PCDH19 ZNF134 24818964 2965264 Regulation PCDH19 ZNF135 24818964 2965265 Regulation PCDH19 ZNF136 24818964 2965266 Regulation PCDH19 ZNF138 24818964 2965267 Regulation PCDH19 ZNF14 24818964 2965268 Regulation PCDH19 ZNF140 24818964 2965269 Regulation PCDH19 ZNF141 24818964 2965270 Regulation PCDH19 ZNF142 24818964 2965271 Regulation PCDH19 ZNF143 24818964 2965272 Regulation PCDH19 ZNF146 24818964 2965273 Regulation PCDH19 ZNF148 24818964 2965274 Regulation PCDH19 ZNF154 24818964 2965275 Regulation PCDH19 ZNF155 24818964 2965276 Regulation PCDH19 ZNF157 24818964 2965277 Regulation PCDH19 ZNF16 24818964 2965279 Regulation PCDH19 ZNF160 24818964 2965280 Regulation PCDH19 ZNF165 24818964 2965281 Regulation PCDH19 ZNF169 24818964 2965282 Regulation PCDH19 ZNF17 24818964 2965283 Regulation PCDH19 ZNF174 24818964 2965284 Regulation PCDH19 ZNF175 24818964 2965285 Regulation PCDH19 ZNF177 24818964 2965286 Regulation PCDH19 ZNF18 24818964 2965287 Regulation PCDH19 ZNF180 24818964 2965288 Regulation PCDH19 ZNF181 24818964 2965289 Regulation PCDH19 ZNF182 24818964 2965303 Regulation PCDH19 ZNF184 24818964 2965290 Regulation PCDH19 ZNF185 24818964 2965291 Regulation PCDH19 ZNF189 24818964 2965292 Regulation PCDH19 ZNF19 24818964 2965293 Regulation PCDH19 ZNF195 24818964 2965294 Regulation PCDH19 ZNF197 24818964 2965295 Regulation PCDH19 ZNF2 24818964 2965296 Regulation PCDH19 ZNF20 24818964 2965297 Regulation PCDH19 ZNF200 24818964 2965298 Regulation PCDH19 ZNF202 24818964 2965299 Regulation PCDH19 ZNF205 24818964 2965300 Regulation PCDH19 ZNF207 24818964 2965301 Regulation PCDH19 ZNF208 24818964 2965302 Regulation PCDH19 ZNF211 24818964 2965304 Regulation PCDH19 ZNF212 24818964 2965305 Regulation PCDH19 ZNF213 24818964 2965306 Regulation PCDH19 ZNF214 24818964 2965307 Regulation PCDH19 ZNF215 24818964 2965308 Regulation PCDH19 ZNF217 24818964 2965309 Regulation PCDH19 ZNF219 24818964 2965310 Regulation PCDH19 ZNF22 24818964 2965311 Regulation PCDH19 ZNF221 24818964 2965312 Regulation PCDH19 ZNF222 24818964 2965313 Regulation PCDH19 ZNF223 24818964 2965314 Regulation PCDH19 ZNF224 24818964 2965315 Regulation PCDH19 ZNF225 24818964 2965316 Regulation PCDH19 ZNF226 24818964 2965317 Regulation PCDH19 ZNF227 24818964 2965318 Regulation PCDH19 ZNF229 24818964 2965319 Regulation PCDH19 ZNF23 24818964 2965320 Regulation PCDH19 ZNF230 24818964 2965321 Regulation PCDH19 ZNF232 24818964 2965322 Regulation PCDH19 ZNF233 24818964 2965686 Regulation PCDH19 ZNF234 24818964 2965323 Regulation PCDH19 ZNF235 24818964 2965249 Regulation PCDH19 ZNF236 24818964 2965324 Regulation PCDH19 ZNF239 24818964 2965325 Regulation PCDH19 ZNF24 24818964 2965326 Regulation PCDH19 ZNF248 24818964 2965327 Regulation PCDH19 ZNF25 24818964 2965328 Regulation PCDH19 ZNF250 24818964 2965329 Regulation PCDH19 ZNF251 24818964 2965330 Regulation PCDH19 ZNF253 24818964 2965387 Regulation PCDH19 ZNF254 24818964 2965331 Regulation PCDH19 ZNF256 24818964 2965332 Regulation PCDH19 ZNF257 24818964 2965388 Regulation PCDH19 ZNF259 24818964 2965333 Regulation PCDH19 ZNF26 24818964 2965334 Regulation PCDH19 ZNF260 24818964 2965389 Regulation PCDH19 ZNF263 24818964 2965335 Regulation PCDH19 ZNF264 24818964 2965336 Regulation PCDH19 ZNF266 24818964 2965337 Regulation PCDH19 ZNF267 24818964 2965338 Regulation PCDH19 ZNF268 24818964 2965339 Regulation PCDH19 ZNF271 24818964 2965340 Regulation PCDH19 ZNF273 24818964 2965341 Regulation PCDH19 ZNF274 24818964 2965342 Regulation PCDH19 ZNF275 24818964 2965343 Regulation PCDH19 ZNF276 24818964 2965492 Regulation PCDH19 ZNF277 24818964 2965344 Regulation PCDH19 ZNF28 24818964 2965345 Regulation PCDH19 ZNF281 24818964 2965346 Regulation PCDH19 ZNF282 24818964 2965347 Regulation PCDH19 ZNF283 24818964 2965348 Regulation PCDH19 ZNF284 24818964 2965349 Regulation PCDH19 ZNF285 24818964 2965350 Regulation PCDH19 ZNF287 24818964 2965390 Regulation PCDH19 ZNF292 24818964 2965430 Regulation PCDH19 ZNF296 24818964 2965408 Regulation PCDH19 ZNF3 24818964 2965351 Regulation PCDH19 ZNF30 24818964 2965352 Regulation PCDH19 ZNF300 24818964 2965353 Regulation PCDH19 ZNF302 24818964 2965398 Regulation PCDH19 ZNF304 24818964 2965391 Regulation PCDH19 ZNF311 24818964 2965397 Regulation PCDH19 ZNF316 24818964 2965396 Regulation PCDH19 ZNF317 24818964 2965392 Regulation PCDH19 ZNF318 24818964 2965393 Regulation PCDH19 ZNF319 24818964 2965394 Regulation PCDH19 ZNF32 24818964 2965354 Regulation PCDH19 ZNF320 24818964 2965395 Regulation PCDH19 ZNF322 24818964 2965499 Regulation PCDH19 ZNF324 24818964 2965399 Regulation PCDH19 ZNF326 24818964 2965400 Regulation PCDH19 ZNF329 24818964 2965401 Regulation PCDH19 ZNF330 24818964 2965402 Regulation PCDH19 ZNF331 24818964 2965403 Regulation PCDH19 ZNF333 24818964 2965404 Regulation PCDH19 ZNF334 24818964 2965405 Regulation PCDH19 ZNF335 24818964 2965406 Regulation PCDH19 ZNF337 24818964 2965407 Regulation PCDH19 ZNF34 24818964 2965355 Regulation PCDH19 ZNF341 24818964 2965409 Regulation PCDH19 ZNF343 24818964 2965410 Regulation PCDH19 ZNF345 24818964 2965413 Regulation PCDH19 ZNF346 24818964 2965414 Regulation PCDH19 ZNF347 24818964 2965415 Regulation PCDH19 ZNF35 24818964 2965356 Regulation PCDH19 ZNF350 24818964 2965416 Regulation PCDH19 ZNF358 24818964 2965420 Regulation PCDH19 ZNF362 24818964 2965424 Regulation PCDH19 ZNF365 24818964 2965426 Regulation PCDH19 ZNF366 24818964 2965427 Regulation PCDH19 ZNF367 24818964 2965428 Regulation PCDH19 ZNF382 24818964 2965421 Regulation PCDH19 ZNF383 24818964 2965431 Regulation PCDH19 ZNF384 24818964 2965248 Regulation PCDH19 ZNF391 24818964 2965433 Regulation PCDH19 ZNF394 24818964 2965436 Regulation PCDH19 ZNF395 24818964 2965432 Regulation PCDH19 ZNF396 24818964 2965435 Regulation PCDH19 ZNF397 24818964 2965434 Regulation PCDH19 ZNF398 24818964 2965429 Regulation PCDH19 ZNF404 24818964 2965437 Regulation PCDH19 ZNF407 24818964 2965438 Regulation PCDH19 ZNF408 24818964 2965439 Regulation PCDH19 ZNF41 24818964 2965357 Regulation PCDH19 ZNF410 24818964 2965440 Regulation PCDH19 ZNF414 24818964 2965444 Regulation PCDH19 ZNF415 24818964 2965445 Regulation PCDH19 ZNF416 24818964 2965446 Regulation PCDH19 ZNF417 24818964 2965447 Regulation PCDH19 ZNF418 24818964 2965448 Regulation PCDH19 ZNF419 24818964 2965449 Regulation PCDH19 ZNF420 24818964 2965450 Regulation PCDH19 ZNF423 24818964 2965419 Regulation PCDH19 ZNF425 24818964 2965451 Regulation PCDH19 ZNF426 24818964 2965452 Regulation PCDH19 ZNF428 24818964 2965453 Regulation PCDH19 ZNF429 24818964 2965460 Regulation PCDH19 ZNF43 24818964 2965358 Regulation PCDH19 ZNF430 24818964 2965455 Regulation PCDH19 ZNF431 24818964 2965456 Regulation PCDH19 ZNF432 24818964 2965457 Regulation PCDH19 ZNF433 24818964 2965458 Regulation PCDH19 ZNF436 24818964 2965459 Regulation PCDH19 ZNF438 24818964 2965467 Regulation PCDH19 ZNF439 24818964 2965461 Regulation PCDH19 ZNF44 24818964 2965359 Regulation PCDH19 ZNF440 24818964 2965462 Regulation PCDH19 ZNF441 24818964 2965463 Regulation PCDH19 ZNF442 24818964 2965464 Regulation PCDH19 ZNF443 24818964 2965465 Regulation PCDH19 ZNF444 24818964 2965411 Regulation PCDH19 ZNF445 24818964 2965466 Regulation PCDH19 ZNF446 24818964 2965468 Regulation PCDH19 ZNF449 24818964 2965469 Regulation PCDH19 ZNF45 24818964 2965360 Regulation PCDH19 ZNF451 24818964 2965470 Regulation PCDH19 ZNF454 24818964 2965471 Regulation PCDH19 ZNF460 24818964 2965472 Regulation PCDH19 ZNF461 24818964 2965473 Regulation PCDH19 ZNF462 24818964 2965474 Regulation PCDH19 ZNF467 24818964 2965483 Regulation PCDH19 ZNF468 24818964 2965708 Regulation PCDH19 ZNF469 24818964 2965485 Regulation PCDH19 ZNF470 24818964 2965481 Regulation PCDH19 ZNF471 24818964 2965486 Regulation PCDH19 ZNF473 24818964 2965487 Regulation PCDH19 ZNF474 24818964 2965488 Regulation PCDH19 ZNF479 24818964 2965489 Regulation PCDH19 ZNF48 24818964 2965361 Regulation PCDH19 ZNF480 24818964 2965491 Regulation PCDH19 ZNF483 24818964 2965493 Regulation PCDH19 ZNF484 24818964 2965494 Regulation PCDH19 ZNF485 24818964 2965495 Regulation PCDH19 ZNF486 24818964 2965454 Regulation PCDH19 ZNF487 24818964 2965496 Regulation PCDH19 ZNF488 24818964 2965497 Regulation PCDH19 ZNF490 24818964 2965500 Regulation PCDH19 ZNF491 24818964 2965501 Regulation PCDH19 ZNF492 24818964 2965502 Regulation PCDH19 ZNF493 24818964 2965503 Regulation PCDH19 ZNF496 24818964 2965504 Regulation PCDH19 ZNF497 24818964 2965505 Regulation PCDH19 ZNF500 24818964 2965506 Regulation PCDH19 ZNF501 24818964 2965507 Regulation PCDH19 ZNF502 24818964 2965508 Regulation PCDH19 ZNF503 24818964 2965498 Regulation PCDH19 ZNF506 24818964 2965509 Regulation PCDH19 ZNF507 24818964 2965510 Regulation PCDH19 ZNF510 24818964 2965656 Regulation PCDH19 ZNF511 24818964 2965630 Regulation PCDH19 ZNF512 24818964 2965663 Regulation PCDH19 ZNF513 24818964 2965575 Regulation PCDH19 ZNF514 24818964 2965549 Regulation PCDH19 ZNF516 24818964 2965649 Regulation PCDH19 ZNF517 24818964 2965610 Regulation PCDH19 ZNF519 24818964 2965680 Regulation PCDH19 ZNF521 24818964 2965511 Regulation PCDH19 ZNF524 24818964 2965625 Regulation PCDH19 ZNF525 24818964 2965669 Regulation PCDH19 ZNF526 24818964 2965667 Regulation PCDH19 ZNF527 24818964 2965665 Regulation PCDH19 ZNF528 24818964 2965664 Regulation PCDH19 ZNF529 24818964 2965662 Regulation PCDH19 ZNF530 24818964 2965661 Regulation PCDH19 ZNF532 24818964 2965684 Regulation PCDH19 ZNF534 24818964 2965561 Regulation PCDH19 ZNF536 24818964 2965653 Regulation PCDH19 ZNF540 24818964 2965531 Regulation PCDH19 ZNF541 24818964 2965530 Regulation PCDH19 ZNF542 24818964 2965535 Regulation PCDH19 ZNF543 24818964 2965528 Regulation PCDH19 ZNF544 24818964 2965418 Regulation PCDH19 ZNF546 24818964 2965637 Regulation PCDH19 ZNF547 24818964 2965569 Regulation PCDH19 ZNF548 24818964 2965576 Regulation PCDH19 ZNF549 24818964 2965579 Regulation PCDH19 ZNF550 24818964 2965634 Regulation PCDH19 ZNF551 24818964 2965522 Regulation PCDH19 ZNF552 24818964 2965556 Regulation PCDH19 ZNF554 24818964 2965578 Regulation PCDH19 ZNF555 24818964 2965628 Regulation PCDH19 ZNF556 24818964 2965539 Regulation PCDH19 ZNF557 24818964 2965633 Regulation PCDH19 ZNF558 24818964 2965567 Regulation PCDH19 ZNF559 24818964 2965622 Regulation PCDH19 ZNF56 24818964 2965362 Regulation PCDH19 ZNF560 24818964 2965573 Regulation PCDH19 ZNF561 24818964 2965639 Regulation PCDH19 ZNF562 24818964 2965553 Regulation PCDH19 ZNF563 24818964 2965677 Regulation PCDH19 ZNF564 24818964 2965692 Regulation PCDH19 ZNF565 24818964 2965583 Regulation PCDH19 ZNF566 24818964 2965550 Regulation PCDH19 ZNF567 24818964 2965640 Regulation PCDH19 ZNF568 24818964 2965534 Regulation PCDH19 ZNF569 24818964 2965513 Regulation PCDH19 ZNF57 24818964 2965363 Regulation PCDH19 ZNF570 24818964 2965564 Regulation PCDH19 ZNF571 24818964 2965519 Regulation PCDH19 ZNF572 24818964 2965585 Regulation PCDH19 ZNF573 24818964 2965565 Regulation PCDH19 ZNF574 24818964 2965557 Regulation PCDH19 ZNF575 24818964 2965604 Regulation PCDH19 ZNF576 24818964 2965627 Regulation PCDH19 ZNF577 24818964 2965638 Regulation PCDH19 ZNF578 24818964 2965570 Regulation PCDH19 ZNF579 24818964 2965580 Regulation PCDH19 ZNF580 24818964 2965672 Regulation PCDH19 ZNF581 24818964 2965520 Regulation PCDH19 ZNF582 24818964 2965566 Regulation PCDH19 ZNF583 24818964 2965568 Regulation PCDH19 ZNF584 24818964 2965602 Regulation PCDH19 ZNF586 24818964 2965552 Regulation PCDH19 ZNF587 24818964 2965690 Regulation PCDH19 ZNF589 24818964 2965417 Regulation PCDH19 ZNF592 24818964 2965648 Regulation PCDH19 ZNF593 24818964 2965685 Regulation PCDH19 ZNF594 24818964 2965666 Regulation PCDH19 ZNF595 24818964 2965596 Regulation PCDH19 ZNF596 24818964 2965600 Regulation PCDH19 ZNF597 24818964 2965577 Regulation PCDH19 ZNF598 24818964 2965619 Regulation PCDH19 ZNF599 24818964 2965563 Regulation PCDH19 ZNF600 24818964 2965688 Regulation PCDH19 ZNF605 24818964 2965617 Regulation PCDH19 ZNF606 24818964 2965546 Regulation PCDH19 ZNF607 24818964 2965621 Regulation PCDH19 ZNF608 24818964 2965658 Regulation PCDH19 ZNF609 24818964 2965650 Regulation PCDH19 ZNF610 24818964 2965581 Regulation PCDH19 ZNF611 24818964 2965644 Regulation PCDH19 ZNF613 24818964 2965543 Regulation PCDH19 ZNF614 24818964 2965512 Regulation PCDH19 ZNF615 24818964 2965514 Regulation PCDH19 ZNF616 24818964 2965615 Regulation PCDH19 ZNF618 24818964 2965668 Regulation PCDH19 ZNF619 24818964 2965590 Regulation PCDH19 ZNF620 24818964 2965643 Regulation PCDH19 ZNF621 24818964 2965517 Regulation PCDH19 ZNF622 24818964 2965691 Regulation PCDH19 ZNF623 24818964 2965654 Regulation PCDH19 ZNF624 24818964 2965659 Regulation PCDH19 ZNF625 24818964 2965679 Regulation PCDH19 ZNF626 24818964 2965674 Regulation PCDH19 ZNF627 24818964 2965678 Regulation PCDH19 ZNF628 24818964 2965614 Regulation PCDH19 ZNF629 24818964 2965652 Regulation PCDH19 ZNF630 24818964 2965646 Regulation PCDH19 ZNF638 24818964 2965423 Regulation PCDH19 ZNF639 24818964 2965687 Regulation PCDH19 ZNF641 24818964 2965693 Regulation PCDH19 ZNF644 24818964 2965657 Regulation PCDH19 ZNF645 24818964 2965562 Regulation PCDH19 ZNF646 24818964 2965651 Regulation PCDH19 ZNF648 24818964 2965425 Regulation PCDH19 ZNF649 24818964 2965541 Regulation PCDH19 ZNF652 24818964 2965655 Regulation PCDH19 ZNF653 24818964 2965526 Regulation PCDH19 ZNF654 24818964 2965538 Regulation PCDH19 ZNF655 24818964 2965682 Regulation PCDH19 ZNF658 24818964 2965527 Regulation PCDH19 ZNF66 24818964 2965365 Regulation PCDH19 ZNF660 24818964 2965582 Regulation PCDH19 ZNF662 24818964 2965694 Regulation PCDH19 ZNF663 24818964 2965532 Regulation PCDH19 ZNF664 24818964 2965536 Regulation PCDH19 ZNF665 24818964 2965548 Regulation PCDH19 ZNF667 24818964 2965645 Regulation PCDH19 ZNF668 24818964 2965542 Regulation PCDH19 ZNF669 24818964 2965540 Regulation PCDH19 ZNF670 24818964 2965620 Regulation PCDH19 ZNF671 24818964 2965560 Regulation PCDH19 ZNF672 24818964 2965558 Regulation PCDH19 ZNF674 24818964 2965422 Regulation PCDH19 ZNF675 24818964 2965681 Regulation PCDH19 ZNF676 24818964 2965442 Regulation PCDH19 ZNF677 24818964 2965642 Regulation PCDH19 ZNF678 24818964 2965636 Regulation PCDH19 ZNF679 24818964 2965635 Regulation PCDH19 ZNF680 24818964 2965589 Regulation PCDH19 ZNF681 24818964 2965571 Regulation PCDH19 ZNF682 24818964 2965647 Regulation PCDH19 ZNF683 24818964 2965631 Regulation PCDH19 ZNF684 24818964 2965629 Regulation PCDH19 ZNF687 24818964 2965660 Regulation PCDH19 ZNF688 24818964 2965676 Regulation PCDH19 ZNF689 24818964 2965525 Regulation PCDH19 ZNF69 24818964 2965366 Regulation PCDH19 ZNF691 24818964 2965612 Regulation PCDH19 ZNF692 24818964 2965554 Regulation PCDH19 ZNF695 24818964 2965689 Regulation PCDH19 ZNF696 24818964 2965545 Regulation PCDH19 ZNF697 24818964 2965695 Regulation PCDH19 ZNF699 24818964 2965515 Regulation PCDH19 ZNF7 24818964 2965367 Regulation PCDH19 ZNF70 24818964 2965368 Regulation PCDH19 ZNF700 24818964 2965529 Regulation PCDH19 ZNF701 24818964 2965537 Regulation PCDH19 ZNF703 24818964 2965547 Regulation PCDH19 ZNF704 24818964 2965697 Regulation PCDH19 ZNF706 24818964 2965518 Regulation PCDH19 ZNF707 24818964 2965609 Regulation PCDH19 ZNF708 24818964 2965278 Regulation PCDH19 ZNF709 24818964 2965443 Regulation PCDH19 ZNF71 24818964 2965369 Regulation PCDH19 ZNF710 24818964 2965533 Regulation PCDH19 ZNF711 24818964 2965364 Regulation PCDH19 ZNF713 24818964 2965479 Regulation PCDH19 ZNF714 24818964 2965594 Regulation PCDH19 ZNF716 24818964 2965698 Regulation PCDH19 ZNF717 24818964 2965671 Regulation PCDH19 ZNF718 24818964 2965587 Regulation PCDH19 ZNF720 24818964 2965591 Regulation PCDH19 ZNF721 24818964 2965670 Regulation PCDH19 ZNF723 24818964 2965696 Regulation PCDH19 ZNF726 24818964 2965699 Regulation PCDH19 ZNF727 24818964 2965482 Regulation PCDH19 ZNF728 24818964 2965700 Regulation PCDH19 ZNF729 24818964 2965701 Regulation PCDH19 ZNF73 24818964 2965370 Regulation PCDH19 ZNF730 24818964 2965706 Regulation PCDH19 ZNF732 24818964 2965728 Regulation PCDH19 ZNF735 24818964 2965702 Regulation PCDH19 ZNF736 24818964 2965703 Regulation PCDH19 ZNF737 24818964 2965704 Regulation PCDH19 ZNF738 24818964 2965705 Regulation PCDH19 ZNF74 24818964 2965371 Regulation PCDH19 ZNF740 24818964 2965603 Regulation PCDH19 ZNF746 24818964 2965478 Regulation PCDH19 ZNF747 24818964 2965626 Regulation PCDH19 ZNF749 24818964 2965707 Regulation PCDH19 ZNF750 24818964 2965544 Regulation PCDH19 ZNF76 24818964 2965372 Regulation PCDH19 ZNF761 24818964 2965484 Regulation PCDH19 ZNF763 24818964 2965606 Regulation PCDH19 ZNF764 24818964 2965623 Regulation PCDH19 ZNF765 24818964 2965521 Regulation PCDH19 ZNF766 24818964 2965616 Regulation PCDH19 ZNF767 24818964 2965477 Regulation PCDH19 ZNF768 24818964 2965559 Regulation PCDH19 ZNF77 24818964 2965373 Regulation PCDH19 ZNF770 24818964 2965555 Regulation PCDH19 ZNF771 24818964 2965673 Regulation PCDH19 ZNF772 24818964 2965709 Regulation PCDH19 ZNF773 24818964 2965675 Regulation PCDH19 ZNF774 24818964 2965710 Regulation PCDH19 ZNF775 24818964 2965632 Regulation PCDH19 ZNF776 24818964 2965586 Regulation PCDH19 ZNF777 24818964 2965480 Regulation PCDH19 ZNF778 24818964 2965572 Regulation PCDH19 ZNF781 24818964 2965584 Regulation PCDH19 ZNF782 24818964 2965711 Regulation PCDH19 ZNF783 24818964 2965597 Regulation PCDH19 ZNF784 24818964 2965712 Regulation PCDH19 ZNF785 24818964 2965574 Regulation PCDH19 ZNF786 24818964 2965476 Regulation PCDH19 ZNF787 24818964 2965593 Regulation PCDH19 ZNF788 24818964 2965713 Regulation PCDH19 ZNF789 24818964 2965608 Regulation PCDH19 ZNF79 24818964 2965374 Regulation PCDH19 ZNF790 24818964 2965714 Regulation PCDH19 ZNF791 24818964 2965588 Regulation PCDH19 ZNF792 24818964 2965516 Regulation PCDH19 ZNF793 24818964 2965715 Regulation PCDH19 ZNF799 24818964 2965618 Regulation PCDH19 ZNF8 24818964 2965375 Regulation PCDH19 ZNF80 24818964 2965376 Regulation PCDH19 ZNF800 24818964 2965599 Regulation PCDH19 ZNF805 24818964 2965490 Regulation PCDH19 ZNF806 24818964 2965716 Regulation PCDH19 ZNF807 24818964 2965717 Regulation PCDH19 ZNF808 24818964 2965718 Regulation PCDH19 ZNF81 24818964 2965377 Regulation PCDH19 ZNF812 24818964 2965719 Regulation PCDH19 ZNF813 24818964 2965720 Regulation PCDH19 ZNF814 24818964 2965721 Regulation PCDH19 ZNF816 24818964 2965592 Regulation PCDH19 ZNF821 24818964 2965613 Regulation PCDH19 ZNF823 24818964 2965683 Regulation PCDH19 ZNF827 24818964 2965595 Regulation PCDH19 ZNF829 24818964 2965722 Regulation PCDH19 ZNF83 24818964 2965378 Regulation PCDH19 ZNF830 24818964 2965624 Regulation PCDH19 ZNF831 24818964 2965412 Regulation PCDH19 ZNF835 24818964 2965723 Regulation PCDH19 ZNF836 24818964 2965724 Regulation PCDH19 ZNF837 24818964 2965524 Regulation PCDH19 ZNF839 24818964 2965441 Regulation PCDH19 ZNF84 24818964 2965379 Regulation PCDH19 ZNF840 24818964 2965725 Regulation PCDH19 ZNF841 24818964 2965605 Regulation PCDH19 ZNF843 24818964 2965641 Regulation PCDH19 ZNF844 24818964 2965551 Regulation PCDH19 ZNF845 24818964 2965523 Regulation PCDH19 ZNF846 24818964 2965598 Regulation PCDH19 ZNF85 24818964 2965380 Regulation PCDH19 ZNF850 24818964 2965611 Regulation PCDH19 ZNF852 24818964 2965607 Regulation PCDH19 ZNF853 24818964 2965475 Regulation PCDH19 ZNF860 24818964 2965726 Regulation PCDH19 ZNF862 24818964 2965727 Regulation PCDH19 ZNF865 24818964 2965733 Regulation PCDH19 ZNF878 24818964 2965729 Regulation PCDH19 ZNF879 24818964 2965731 Regulation PCDH19 ZNF880 24818964 2965730 Regulation PCDH19 ZNF883 24818964 2965601 Regulation PCDH19 ZNF888 24818964 2965732 Regulation PCDH19 ZNF891 24818964 2965734 Regulation PCDH19 ZNF90 24818964 2965381 Regulation PCDH19 ZNF91 24818964 2965382 Regulation PCDH19 ZNF92 24818964 2965383 Regulation PCDH19 ZNF93 24818964 2965384 Regulation PCDH19 ZNF98 24818964 2965385 Regulation PCDH19 ZNF99 24818964 2965386 Regulation PCDH8 CTCF 22210889 2071216 Regulation PCDH8 CTCF 22988450 882919 Regulation PCDH8 REST 20385576 2052923 Regulation PCDH8 SMCHD1 24818964 2968677 Regulation PCDH8 ZNF10 24818964 2967685 Regulation PCDH8 ZNF100 24818964 2967686 Regulation PCDH8 ZNF101 24818964 2967687 Regulation PCDH8 ZNF106 24818964 2967688 Regulation PCDH8 ZNF107 24818964 2967689 Regulation PCDH8 ZNF112 24818964 2967690 Regulation PCDH8 ZNF114 24818964 2967691 Regulation PCDH8 ZNF117 24818964 2967692 Regulation PCDH8 ZNF12 24818964 2967693 Regulation PCDH8 ZNF121 24818964 2967694 Regulation PCDH8 ZNF124 24818964 2967695 Regulation PCDH8 ZNF131 24818964 2967696 Regulation PCDH8 ZNF132 24818964 2967697 Regulation PCDH8 ZNF133 24818964 2967698 Regulation PCDH8 ZNF134 24818964 2967699 Regulation PCDH8 ZNF135 24818964 2967700 Regulation PCDH8 ZNF136 24818964 2967701 Regulation PCDH8 ZNF138 24818964 2967702 Regulation PCDH8 ZNF14 24818964 2967703 Regulation PCDH8 ZNF140 24818964 2967704 Regulation PCDH8 ZNF141 24818964 2967705 Regulation PCDH8 ZNF142 24818964 2967706 Regulation PCDH8 ZNF143 24818964 2967707 Regulation PCDH8 ZNF146 24818964 2967708 Regulation PCDH8 ZNF148 24818964 2967709 Regulation PCDH8 ZNF154 24818964 2967710 Regulation PCDH8 ZNF155 24818964 2967711 Regulation PCDH8 ZNF157 24818964 2967712 Regulation PCDH8 ZNF16 24818964 2967714 Regulation PCDH8 ZNF160 24818964 2967715 Regulation PCDH8 ZNF165 24818964 2967716 Regulation PCDH8 ZNF169 24818964 2967717 Regulation PCDH8 ZNF17 24818964 2967718 Regulation PCDH8 ZNF174 24818964 2967719 Regulation PCDH8 ZNF175 24818964 2967720 Regulation PCDH8 ZNF177 24818964 2967721 Regulation PCDH8 ZNF18 24818964 2967722 Regulation PCDH8 ZNF180 24818964 2967723 Regulation PCDH8 ZNF181 24818964 2967724 Regulation PCDH8 ZNF182 24818964 2967738 Regulation PCDH8 ZNF184 24818964 2967725 Regulation PCDH8 ZNF185 24818964 2967726 Regulation PCDH8 ZNF189 24818964 2967727 Regulation PCDH8 ZNF19 24818964 2967728 Regulation PCDH8 ZNF195 24818964 2967729 Regulation PCDH8 ZNF197 24818964 2967730 Regulation PCDH8 ZNF2 24818964 2967731 Regulation PCDH8 ZNF20 24818964 2967732 Regulation PCDH8 ZNF200 24818964 2967733 Regulation PCDH8 ZNF202 24818964 2967734 Regulation PCDH8 ZNF205 24818964 2967735 Regulation PCDH8 ZNF207 24818964 2967736 Regulation PCDH8 ZNF208 24818964 2967737 Regulation PCDH8 ZNF211 24818964 2967739 Regulation PCDH8 ZNF212 24818964 2967740 Regulation PCDH8 ZNF213 24818964 2967741 Regulation PCDH8 ZNF214 24818964 2967742 Regulation PCDH8 ZNF215 24818964 2967743 Regulation PCDH8 ZNF217 24818964 2967744 Regulation PCDH8 ZNF219 24818964 2967745 Regulation PCDH8 ZNF22 24818964 2967746 Regulation PCDH8 ZNF221 24818964 2967747 Regulation PCDH8 ZNF222 24818964 2967748 Regulation PCDH8 ZNF223 24818964 2967749 Regulation PCDH8 ZNF224 24818964 2967750 Regulation PCDH8 ZNF225 24818964 2967751 Regulation PCDH8 ZNF226 24818964 2967752 Regulation PCDH8 ZNF227 24818964 2967753 Regulation PCDH8 ZNF229 24818964 2967754 Regulation PCDH8 ZNF23 24818964 2967755 Regulation PCDH8 ZNF230 24818964 2967756 Regulation PCDH8 ZNF232 24818964 2967757 Regulation PCDH8 ZNF233 24818964 2968121 Regulation PCDH8 ZNF234 24818964 2967758 Regulation PCDH8 ZNF235 24818964 2967684 Regulation PCDH8 ZNF236 24818964 2967759 Regulation PCDH8 ZNF239 24818964 2967760 Regulation PCDH8 ZNF24 24818964 2967761 Regulation PCDH8 ZNF248 24818964 2967762 Regulation PCDH8 ZNF25 24818964 2967763 Regulation PCDH8 ZNF250 24818964 2967764 Regulation PCDH8 ZNF251 24818964 2967765 Regulation PCDH8 ZNF253 24818964 2967822 Regulation PCDH8 ZNF254 24818964 2967766 Regulation PCDH8 ZNF256 24818964 2967767 Regulation PCDH8 ZNF257 24818964 2967823 Regulation PCDH8 ZNF259 24818964 2967768 Regulation PCDH8 ZNF26 24818964 2967769 Regulation PCDH8 ZNF260 24818964 2967824 Regulation PCDH8 ZNF263 24818964 2967770 Regulation PCDH8 ZNF264 24818964 2967771 Regulation PCDH8 ZNF266 24818964 2967772 Regulation PCDH8 ZNF267 24818964 2967773 Regulation PCDH8 ZNF268 24818964 2967774 Regulation PCDH8 ZNF271 24818964 2967775 Regulation PCDH8 ZNF273 24818964 2967776 Regulation PCDH8 ZNF274 24818964 2967777 Regulation PCDH8 ZNF275 24818964 2967778 Regulation PCDH8 ZNF276 24818964 2967927 Regulation PCDH8 ZNF277 24818964 2967779 Regulation PCDH8 ZNF28 24818964 2967780 Regulation PCDH8 ZNF281 24818964 2967781 Regulation PCDH8 ZNF282 24818964 2967782 Regulation PCDH8 ZNF283 24818964 2967783 Regulation PCDH8 ZNF284 24818964 2967784 Regulation PCDH8 ZNF285 24818964 2967785 Regulation PCDH8 ZNF287 24818964 2967825 Regulation PCDH8 ZNF292 24818964 2967865 Regulation PCDH8 ZNF296 24818964 2967843 Regulation PCDH8 ZNF3 24818964 2967786 Regulation PCDH8 ZNF30 24818964 2967787 Regulation PCDH8 ZNF300 24818964 2967788 Regulation PCDH8 ZNF302 24818964 2967833 Regulation PCDH8 ZNF304 24818964 2967826 Regulation PCDH8 ZNF311 24818964 2967832 Regulation PCDH8 ZNF316 24818964 2967831 Regulation PCDH8 ZNF317 24818964 2967827 Regulation PCDH8 ZNF318 24818964 2967828 Regulation PCDH8 ZNF319 24818964 2967829 Regulation PCDH8 ZNF32 24818964 2967789 Regulation PCDH8 ZNF320 24818964 2967830 Regulation PCDH8 ZNF322 24818964 2967934 Regulation PCDH8 ZNF324 24818964 2967834 Regulation PCDH8 ZNF326 24818964 2967835 Regulation PCDH8 ZNF329 24818964 2967836 Regulation PCDH8 ZNF330 24818964 2967837 Regulation PCDH8 ZNF331 24818964 2967838 Regulation PCDH8 ZNF333 24818964 2967839 Regulation PCDH8 ZNF334 24818964 2967840 Regulation PCDH8 ZNF335 24818964 2967841 Regulation PCDH8 ZNF337 24818964 2967842 Regulation PCDH8 ZNF34 24818964 2967790 Regulation PCDH8 ZNF341 24818964 2967844 Regulation PCDH8 ZNF343 24818964 2967845 Regulation PCDH8 ZNF345 24818964 2967848 Regulation PCDH8 ZNF346 24818964 2967849 Regulation PCDH8 ZNF347 24818964 2967850 Regulation PCDH8 ZNF35 24818964 2967791 Regulation PCDH8 ZNF350 24818964 2967851 Regulation PCDH8 ZNF358 24818964 2967855 Regulation PCDH8 ZNF362 24818964 2967859 Regulation PCDH8 ZNF365 24818964 2967861 Regulation PCDH8 ZNF366 24818964 2967862 Regulation PCDH8 ZNF367 24818964 2967863 Regulation PCDH8 ZNF382 24818964 2967856 Regulation PCDH8 ZNF383 24818964 2967866 Regulation PCDH8 ZNF384 24818964 2967683 Regulation PCDH8 ZNF391 24818964 2967868 Regulation PCDH8 ZNF394 24818964 2967871 Regulation PCDH8 ZNF395 24818964 2967867 Regulation PCDH8 ZNF396 24818964 2967870 Regulation PCDH8 ZNF397 24818964 2967869 Regulation PCDH8 ZNF398 24818964 2967864 Regulation PCDH8 ZNF404 24818964 2967872 Regulation PCDH8 ZNF407 24818964 2967873 Regulation PCDH8 ZNF408 24818964 2967874 Regulation PCDH8 ZNF41 24818964 2967792 Regulation PCDH8 ZNF410 24818964 2967875 Regulation PCDH8 ZNF414 24818964 2967879 Regulation PCDH8 ZNF415 24818964 2967880 Regulation PCDH8 ZNF416 24818964 2967881 Regulation PCDH8 ZNF417 24818964 2967882 Regulation PCDH8 ZNF418 24818964 2967883 Regulation PCDH8 ZNF419 24818964 2967884 Regulation PCDH8 ZNF420 24818964 2967885 Regulation PCDH8 ZNF423 24818964 2967854 Regulation PCDH8 ZNF425 24818964 2967886 Regulation PCDH8 ZNF426 24818964 2967887 Regulation PCDH8 ZNF428 24818964 2967888 Regulation PCDH8 ZNF429 24818964 2967895 Regulation PCDH8 ZNF43 24818964 2967793 Regulation PCDH8 ZNF430 24818964 2967890 Regulation PCDH8 ZNF431 24818964 2967891 Regulation PCDH8 ZNF432 24818964 2967892 Regulation PCDH8 ZNF433 24818964 2967893 Regulation PCDH8 ZNF436 24818964 2967894 Regulation PCDH8 ZNF438 24818964 2967902 Regulation PCDH8 ZNF439 24818964 2967896 Regulation PCDH8 ZNF44 24818964 2967794 Regulation PCDH8 ZNF440 24818964 2967897 Regulation PCDH8 ZNF441 24818964 2967898 Regulation PCDH8 ZNF442 24818964 2967899 Regulation PCDH8 ZNF443 24818964 2967900 Regulation PCDH8 ZNF444 24818964 2967846 Regulation PCDH8 ZNF445 24818964 2967901 Regulation PCDH8 ZNF446 24818964 2967903 Regulation PCDH8 ZNF449 24818964 2967904 Regulation PCDH8 ZNF45 24818964 2967795 Regulation PCDH8 ZNF451 24818964 2967905 Regulation PCDH8 ZNF454 24818964 2967906 Regulation PCDH8 ZNF460 24818964 2967907 Regulation PCDH8 ZNF461 24818964 2967908 Regulation PCDH8 ZNF462 24818964 2967909 Regulation PCDH8 ZNF467 24818964 2967918 Regulation PCDH8 ZNF468 24818964 2968143 Regulation PCDH8 ZNF469 24818964 2967920 Regulation PCDH8 ZNF470 24818964 2967916 Regulation PCDH8 ZNF471 24818964 2967921 Regulation PCDH8 ZNF473 24818964 2967922 Regulation PCDH8 ZNF474 24818964 2967923 Regulation PCDH8 ZNF479 24818964 2967924 Regulation PCDH8 ZNF48 24818964 2967796 Regulation PCDH8 ZNF480 24818964 2967926 Regulation PCDH8 ZNF483 24818964 2967928 Regulation PCDH8 ZNF484 24818964 2967929 Regulation PCDH8 ZNF485 24818964 2967930 Regulation PCDH8 ZNF486 24818964 2967889 Regulation PCDH8 ZNF487 24818964 2967931 Regulation PCDH8 ZNF488 24818964 2967932 Regulation PCDH8 ZNF490 24818964 2967935 Regulation PCDH8 ZNF491 24818964 2967936 Regulation PCDH8 ZNF492 24818964 2967937 Regulation PCDH8 ZNF493 24818964 2967938 Regulation PCDH8 ZNF496 24818964 2967939 Regulation PCDH8 ZNF497 24818964 2967940 Regulation PCDH8 ZNF500 24818964 2967941 Regulation PCDH8 ZNF501 24818964 2967942 Regulation PCDH8 ZNF502 24818964 2967943 Regulation PCDH8 ZNF503 24818964 2967933 Regulation PCDH8 ZNF506 24818964 2967944 Regulation PCDH8 ZNF507 24818964 2967945 Regulation PCDH8 ZNF510 24818964 2968091 Regulation PCDH8 ZNF511 24818964 2968065 Regulation PCDH8 ZNF512 24818964 2968098 Regulation PCDH8 ZNF513 24818964 2968010 Regulation PCDH8 ZNF514 24818964 2967984 Regulation PCDH8 ZNF516 24818964 2968084 Regulation PCDH8 ZNF517 24818964 2968045 Regulation PCDH8 ZNF519 24818964 2968115 Regulation PCDH8 ZNF521 24818964 2967946 Regulation PCDH8 ZNF524 24818964 2968060 Regulation PCDH8 ZNF525 24818964 2968104 Regulation PCDH8 ZNF526 24818964 2968102 Regulation PCDH8 ZNF527 24818964 2968100 Regulation PCDH8 ZNF528 24818964 2968099 Regulation PCDH8 ZNF529 24818964 2968097 Regulation PCDH8 ZNF530 24818964 2968096 Regulation PCDH8 ZNF532 24818964 2968119 Regulation PCDH8 ZNF534 24818964 2967996 Regulation PCDH8 ZNF536 24818964 2968088 Regulation PCDH8 ZNF540 24818964 2967966 Regulation PCDH8 ZNF541 24818964 2967965 Regulation PCDH8 ZNF542 24818964 2967970 Regulation PCDH8 ZNF543 24818964 2967963 Regulation PCDH8 ZNF544 24818964 2967853 Regulation PCDH8 ZNF546 24818964 2968072 Regulation PCDH8 ZNF547 24818964 2968004 Regulation PCDH8 ZNF548 24818964 2968011 Regulation PCDH8 ZNF549 24818964 2968014 Regulation PCDH8 ZNF550 24818964 2968069 Regulation PCDH8 ZNF551 24818964 2967957 Regulation PCDH8 ZNF552 24818964 2967991 Regulation PCDH8 ZNF554 24818964 2968013 Regulation PCDH8 ZNF555 24818964 2968063 Regulation PCDH8 ZNF556 24818964 2967974 Regulation PCDH8 ZNF557 24818964 2968068 Regulation PCDH8 ZNF558 24818964 2968002 Regulation PCDH8 ZNF559 24818964 2968057 Regulation PCDH8 ZNF56 24818964 2967797 Regulation PCDH8 ZNF560 24818964 2968008 Regulation PCDH8 ZNF561 24818964 2968074 Regulation PCDH8 ZNF562 24818964 2967988 Regulation PCDH8 ZNF563 24818964 2968112 Regulation PCDH8 ZNF564 24818964 2968127 Regulation PCDH8 ZNF565 24818964 2968018 Regulation PCDH8 ZNF566 24818964 2967985 Regulation PCDH8 ZNF567 24818964 2968075 Regulation PCDH8 ZNF568 24818964 2967969 Regulation PCDH8 ZNF569 24818964 2967948 Regulation PCDH8 ZNF57 24818964 2967798 Regulation PCDH8 ZNF570 24818964 2967999 Regulation PCDH8 ZNF571 24818964 2967954 Regulation PCDH8 ZNF572 24818964 2968020 Regulation PCDH8 ZNF573 24818964 2968000 Regulation PCDH8 ZNF574 24818964 2967992 Regulation PCDH8 ZNF575 24818964 2968039 Regulation PCDH8 ZNF576 24818964 2968062 Regulation PCDH8 ZNF577 24818964 2968073 Regulation PCDH8 ZNF578 24818964 2968005 Regulation PCDH8 ZNF579 24818964 2968015 Regulation PCDH8 ZNF580 24818964 2968107 Regulation PCDH8 ZNF581 24818964 2967955 Regulation PCDH8 ZNF582 24818964 2968001 Regulation PCDH8 ZNF583 24818964 2968003 Regulation PCDH8 ZNF584 24818964 2968037 Regulation PCDH8 ZNF586 24818964 2967987 Regulation PCDH8 ZNF587 24818964 2968125 Regulation PCDH8 ZNF589 24818964 2967852 Regulation PCDH8 ZNF592 24818964 2968083 Regulation PCDH8 ZNF593 24818964 2968120 Regulation PCDH8 ZNF594 24818964 2968101 Regulation PCDH8 ZNF595 24818964 2968031 Regulation PCDH8 ZNF596 24818964 2968035 Regulation PCDH8 ZNF597 24818964 2968012 Regulation PCDH8 ZNF598 24818964 2968054 Regulation PCDH8 ZNF599 24818964 2967998 Regulation PCDH8 ZNF600 24818964 2968123 Regulation PCDH8 ZNF605 24818964 2968052 Regulation PCDH8 ZNF606 24818964 2967981 Regulation PCDH8 ZNF607 24818964 2968056 Regulation PCDH8 ZNF608 24818964 2968093 Regulation PCDH8 ZNF609 24818964 2968085 Regulation PCDH8 ZNF610 24818964 2968016 Regulation PCDH8 ZNF611 24818964 2968079 Regulation PCDH8 ZNF613 24818964 2967978 Regulation PCDH8 ZNF614 24818964 2967947 Regulation PCDH8 ZNF615 24818964 2967949 Regulation PCDH8 ZNF616 24818964 2968050 Regulation PCDH8 ZNF618 24818964 2968103 Regulation PCDH8 ZNF619 24818964 2968025 Regulation PCDH8 ZNF620 24818964 2968078 Regulation PCDH8 ZNF621 24818964 2967952 Regulation PCDH8 ZNF622 24818964 2968126 Regulation PCDH8 ZNF623 24818964 2968089 Regulation PCDH8 ZNF624 24818964 2968094 Regulation PCDH8 ZNF625 24818964 2968114 Regulation PCDH8 ZNF626 24818964 2968109 Regulation PCDH8 ZNF627 24818964 2968113 Regulation PCDH8 ZNF628 24818964 2968049 Regulation PCDH8 ZNF629 24818964 2968087 Regulation PCDH8 ZNF630 24818964 2968081 Regulation PCDH8 ZNF638 24818964 2967858 Regulation PCDH8 ZNF639 24818964 2968122 Regulation PCDH8 ZNF641 24818964 2968128 Regulation PCDH8 ZNF644 24818964 2968092 Regulation PCDH8 ZNF645 24818964 2967997 Regulation PCDH8 ZNF646 24818964 2968086 Regulation PCDH8 ZNF648 24818964 2967860 Regulation PCDH8 ZNF649 24818964 2967976 Regulation PCDH8 ZNF652 24818964 2968090 Regulation PCDH8 ZNF653 24818964 2967961 Regulation PCDH8 ZNF654 24818964 2967973 Regulation PCDH8 ZNF655 24818964 2968117 Regulation PCDH8 ZNF658 24818964 2967962 Regulation PCDH8 ZNF66 24818964 2967800 Regulation PCDH8 ZNF660 24818964 2968017 Regulation PCDH8 ZNF662 24818964 2968129 Regulation PCDH8 ZNF663 24818964 2967967 Regulation PCDH8 ZNF664 24818964 2967971 Regulation PCDH8 ZNF665 24818964 2967983 Regulation PCDH8 ZNF667 24818964 2968080 Regulation PCDH8 ZNF668 24818964 2967977 Regulation PCDH8 ZNF669 24818964 2967975 Regulation PCDH8 ZNF670 24818964 2968055 Regulation PCDH8 ZNF671 24818964 2967995 Regulation PCDH8 ZNF672 24818964 2967993 Regulation PCDH8 ZNF674 24818964 2967857 Regulation PCDH8 ZNF675 24818964 2968116 Regulation PCDH8 ZNF676 24818964 2967877 Regulation PCDH8 ZNF677 24818964 2968077 Regulation PCDH8 ZNF678 24818964 2968071 Regulation PCDH8 ZNF679 24818964 2968070 Regulation PCDH8 ZNF680 24818964 2968024 Regulation PCDH8 ZNF681 24818964 2968006 Regulation PCDH8 ZNF682 24818964 2968082 Regulation PCDH8 ZNF683 24818964 2968066 Regulation PCDH8 ZNF684 24818964 2968064 Regulation PCDH8 ZNF687 24818964 2968095 Regulation PCDH8 ZNF688 24818964 2968111 Regulation PCDH8 ZNF689 24818964 2967960 Regulation PCDH8 ZNF69 24818964 2967801 Regulation PCDH8 ZNF691 24818964 2968047 Regulation PCDH8 ZNF692 24818964 2967989 Regulation PCDH8 ZNF695 24818964 2968124 Regulation PCDH8 ZNF696 24818964 2967980 Regulation PCDH8 ZNF697 24818964 2968130 Regulation PCDH8 ZNF699 24818964 2967950 Regulation PCDH8 ZNF7 24818964 2967802 Regulation PCDH8 ZNF70 24818964 2967803 Regulation PCDH8 ZNF700 24818964 2967964 Regulation PCDH8 ZNF701 24818964 2967972 Regulation PCDH8 ZNF703 24818964 2967982 Regulation PCDH8 ZNF704 24818964 2968132 Regulation PCDH8 ZNF706 24818964 2967953 Regulation PCDH8 ZNF707 24818964 2968044 Regulation PCDH8 ZNF708 24818964 2967713 Regulation PCDH8 ZNF709 24818964 2967878 Regulation PCDH8 ZNF71 24818964 2967804 Regulation PCDH8 ZNF710 24818964 2967968 Regulation PCDH8 ZNF711 24818964 2967799 Regulation PCDH8 ZNF713 24818964 2967914 Regulation PCDH8 ZNF714 24818964 2968029 Regulation PCDH8 ZNF716 24818964 2968133 Regulation PCDH8 ZNF717 24818964 2968106 Regulation PCDH8 ZNF718 24818964 2968022 Regulation PCDH8 ZNF720 24818964 2968026 Regulation PCDH8 ZNF721 24818964 2968105 Regulation PCDH8 ZNF723 24818964 2968131 Regulation PCDH8 ZNF726 24818964 2968134 Regulation PCDH8 ZNF727 24818964 2967917 Regulation PCDH8 ZNF728 24818964 2968135 Regulation PCDH8 ZNF729 24818964 2968136 Regulation PCDH8 ZNF73 24818964 2967805 Regulation PCDH8 ZNF730 24818964 2968141 Regulation PCDH8 ZNF732 24818964 2968163 Regulation PCDH8 ZNF735 24818964 2968137 Regulation PCDH8 ZNF736 24818964 2968138 Regulation PCDH8 ZNF737 24818964 2968139 Regulation PCDH8 ZNF738 24818964 2968140 Regulation PCDH8 ZNF74 24818964 2967806 Regulation PCDH8 ZNF740 24818964 2968038 Regulation PCDH8 ZNF746 24818964 2967913 Regulation PCDH8 ZNF747 24818964 2968061 Regulation PCDH8 ZNF749 24818964 2968142 Regulation PCDH8 ZNF750 24818964 2967979 Regulation PCDH8 ZNF76 24818964 2967807 Regulation PCDH8 ZNF761 24818964 2967919 Regulation PCDH8 ZNF763 24818964 2968041 Regulation PCDH8 ZNF764 24818964 2968058 Regulation PCDH8 ZNF765 24818964 2967956 Regulation PCDH8 ZNF766 24818964 2968051 Regulation PCDH8 ZNF767 24818964 2967912 Regulation PCDH8 ZNF768 24818964 2967994 Regulation PCDH8 ZNF77 24818964 2967808 Regulation PCDH8 ZNF770 24818964 2967990 Regulation PCDH8 ZNF771 24818964 2968108 Regulation PCDH8 ZNF772 24818964 2968144 Regulation PCDH8 ZNF773 24818964 2968110 Regulation PCDH8 ZNF774 24818964 2968145 Regulation PCDH8 ZNF775 24818964 2968067 Regulation PCDH8 ZNF776 24818964 2968021 Regulation PCDH8 ZNF777 24818964 2967915 Regulation PCDH8 ZNF778 24818964 2968007 Regulation PCDH8 ZNF781 24818964 2968019 Regulation PCDH8 ZNF782 24818964 2968146 Regulation PCDH8 ZNF783 24818964 2968032 Regulation PCDH8 ZNF784 24818964 2968147 Regulation PCDH8 ZNF785 24818964 2968009 Regulation PCDH8 ZNF786 24818964 2967911 Regulation PCDH8 ZNF787 24818964 2968028 Regulation PCDH8 ZNF788 24818964 2968148 Regulation PCDH8 ZNF789 24818964 2968043 Regulation PCDH8 ZNF79 24818964 2967809 Regulation PCDH8 ZNF790 24818964 2968149 Regulation PCDH8 ZNF791 24818964 2968023 Regulation PCDH8 ZNF792 24818964 2967951 Regulation PCDH8 ZNF793 24818964 2968150 Regulation PCDH8 ZNF799 24818964 2968053 Regulation PCDH8 ZNF8 24818964 2967810 Regulation PCDH8 ZNF80 24818964 2967811 Regulation PCDH8 ZNF800 24818964 2968034 Regulation PCDH8 ZNF805 24818964 2967925 Regulation PCDH8 ZNF806 24818964 2968151 Regulation PCDH8 ZNF807 24818964 2968152 Regulation PCDH8 ZNF808 24818964 2968153 Regulation PCDH8 ZNF81 24818964 2967812 Regulation PCDH8 ZNF812 24818964 2968154 Regulation PCDH8 ZNF813 24818964 2968155 Regulation PCDH8 ZNF814 24818964 2968156 Regulation PCDH8 ZNF816 24818964 2968027 Regulation PCDH8 ZNF821 24818964 2968048 Regulation PCDH8 ZNF823 24818964 2968118 Regulation PCDH8 ZNF827 24818964 2968030 Regulation PCDH8 ZNF829 24818964 2968157 Regulation PCDH8 ZNF83 24818964 2967813 Regulation PCDH8 ZNF830 24818964 2968059 Regulation PCDH8 ZNF831 24818964 2967847 Regulation PCDH8 ZNF835 24818964 2968158 Regulation PCDH8 ZNF836 24818964 2968159 Regulation PCDH8 ZNF837 24818964 2967959 Regulation PCDH8 ZNF839 24818964 2967876 Regulation PCDH8 ZNF84 24818964 2967814 Regulation PCDH8 ZNF840 24818964 2968160 Regulation PCDH8 ZNF841 24818964 2968040 Regulation PCDH8 ZNF843 24818964 2968076 Regulation PCDH8 ZNF844 24818964 2967986 Regulation PCDH8 ZNF845 24818964 2967958 Regulation PCDH8 ZNF846 24818964 2968033 Regulation PCDH8 ZNF85 24818964 2967815 Regulation PCDH8 ZNF850 24818964 2968046 Regulation PCDH8 ZNF852 24818964 2968042 Regulation PCDH8 ZNF853 24818964 2967910 Regulation PCDH8 ZNF860 24818964 2968161 Regulation PCDH8 ZNF862 24818964 2968162 Regulation PCDH8 ZNF865 24818964 2968168 Regulation PCDH8 ZNF878 24818964 2968164 Regulation PCDH8 ZNF879 24818964 2968166 Regulation PCDH8 ZNF880 24818964 2968165 Regulation PCDH8 ZNF883 24818964 2968036 Regulation PCDH8 ZNF888 24818964 2968167 Regulation PCDH8 ZNF891 24818964 2968169 Regulation PCDH8 ZNF90 24818964 2967816 Regulation PCDH8 ZNF91 24818964 2967817 Regulation PCDH8 ZNF92 24818964 2967818 Regulation PCDH8 ZNF93 24818964 2967819 Regulation PCDH8 ZNF98 24818964 2967820 Regulation PCDH8 ZNF99 24818964 2967821 Regulation PCK1 PGC 22577560 1639180 Regulation PCK2 PGC 22577560 1639181 Regulation PCMT1 EPHB2 24358311 2899493 Regulation PCNA CCND1 10471034 415076 Regulation PCNA CCND1 18648506 2393423 Regulation PCNA CCND1 22276175 2590344 Regulation PCNA CCND1 24212955 499353 Regulation PCNA CCND1 24662164 2118598 Regulation PCNA EPHB2 18404517 3089679 Regulation PCNA EPHB2 22310282 2146192 Regulation PCNA FOXO1 11277966 993995 Regulation PCNA IFI27 15606917 1734146 Regulation PCSK9 AKT1S1 25110901 691683 Regulation PCSK9 ANXA2 22848640 2669932 Regulation PCSK9 APLP2 23430252 1206578 Regulation PCSK9 APOB 23544125 2773541 Regulation PCSK9 COG2 25042549 19289 Regulation PCSK9 DM1 24898067 1874903 Regulation PCSK9 ECD 23400816 1206488 Regulation PCSK9 EEF1A2 19687008 1166608 Regulation PCSK9 EEF1A2 24653785 2214593 Regulation PCSK9 HNF1A 19687008 1166607 Regulation PCSK9 HNF1A 19687008 1166624 Regulation PCSK9 HNF1A 19687008 1166626 Regulation PCSK9 HNF1A 24115837 742820 Regulation PCSK9 HNF1A 25110901 691669 Regulation PCSK9 INHBA 21408162 2507100 Regulation PCSK9 INS 25600226 143172 Regulation PCSK9 LDLR 23400816 1206489 Regulation PCSK9 LDLR 25064003 1726964 Regulation PCSK9 LDLR 25600226 143162 Regulation PCSK9 MLST8 25110901 691682 Regulation PCSK9 MTOR 25110901 691685 Regulation PCSK9 PCSK7 25349778 854160 Regulation PCSK9 RPTOR 25110901 691684 Regulation PCSK9 SEC24A 23580231 748956 Regulation PCSK9 SEC24B 23580231 748957 Regulation PCSK9 SIM2 24755036 1701691 Regulation PCSK9 SREBF1 18547436 1722729 Regulation PCSK9 SREBF1 23298392 2113730 Regulation PCSK9 SREBF2 18547436 1722730 Regulation PCSK9 SREBF2 22355267 1059730 Regulation PCSK9 SREBF2 23130136 1157043 Regulation PCSK9 SREBF2 23130136 1157044 Regulation PCSK9 SREBF2 23400816 1206459 Regulation PCSK9 STS 22998978 1724985 Regulation PDC AXIN2 22163035 2577903 Regulation PDC TLR7 21912648 2552553 Regulation PDC TLR7 22414065 398546 Regulation PDCD1 CAPN8 16776830 383291 Regulation PDCD1 CCND1 23606879 818613 Regulation PDCD1 FAS 21088713 1044785 Regulation PDCD1 FAS 24025186 367193 Regulation PDCD1 FAS 9126933 1601082 Regulation PDCD1 MMP28 11250717 456823 Regulation PDCD1 MMP7 11250717 456838 Regulation PDCD1 TNF 11720454 420196 Regulation PDCD1 TNF 12816542 3095039 Regulation PDCD1 TNF 16584110 630396 Regulation PDCD1 TNF 9653098 1603164 Regulation PDCD10 CAPN8 16776830 383306 Regulation PDCD10 CCND1 23606879 818614 Regulation PDCD10 FAS 21088713 1044786 Regulation PDCD10 FAS 24025186 367194 Regulation PDCD10 FAS 9126933 1601084 Regulation PDCD10 MMP28 11250717 456845 Regulation PDCD10 MMP7 11250717 456860 Regulation PDCD10 TNF 11720454 420197 Regulation PDCD10 TNF 12816542 3095040 Regulation PDCD10 TNF 16584110 630397 Regulation PDCD10 TNF 9653098 1603165 Regulation PDCD11 CAPN8 16776830 383276 Regulation PDCD11 CCND1 23606879 818612 Regulation PDCD11 FAS 21088713 1044784 Regulation PDCD11 FAS 24025186 367192 Regulation PDCD11 FAS 9126933 1601080 Regulation PDCD11 MMP28 11250717 456801 Regulation PDCD11 MMP7 11250717 456816 Regulation PDCD11 TNF 11720454 420195 Regulation PDCD11 TNF 12816542 3095038 Regulation PDCD11 TNF 16584110 630395 Regulation PDCD11 TNF 9653098 1603163 Regulation PDCD2 CAPN8 16776830 383321 Regulation PDCD2 CCND1 23606879 818615 Regulation PDCD2 FAS 21088713 1044787 Regulation PDCD2 FAS 24025186 367195 Regulation PDCD2 FAS 9126933 1601086 Regulation PDCD2 MMP28 11250717 456867 Regulation PDCD2 MMP7 11250717 456882 Regulation PDCD2 TNF 11720454 420198 Regulation PDCD2 TNF 12816542 3095041 Regulation PDCD2 TNF 16584110 630398 Regulation PDCD2 TNF 9653098 1603166 Regulation PDCD4 CAPN8 16776830 383336 Regulation PDCD4 CCND1 23606879 818616 Regulation PDCD4 FAS 21088713 1044788 Regulation PDCD4 FAS 24025186 367196 Regulation PDCD4 FAS 9126933 1601088 Regulation PDCD4 JAG1 25144746 3001221 Regulation PDCD4 MMP28 11250717 456889 Regulation PDCD4 MMP7 11250717 456904 Regulation PDCD4 TNF 11720454 420199 Regulation PDCD4 TNF 12816542 3095042 Regulation PDCD4 TNF 16584110 630399 Regulation PDCD4 TNF 9653098 1603167 Regulation PDCD5 CAPN8 16776830 383351 Regulation PDCD5 CCND1 23606879 818617 Regulation PDCD5 FAS 21088713 1044789 Regulation PDCD5 FAS 24025186 367197 Regulation PDCD5 FAS 9126933 1601090 Regulation PDCD5 MMP28 11250717 456911 Regulation PDCD5 MMP7 11250717 456926 Regulation PDCD5 TNF 11720454 420200 Regulation PDCD5 TNF 12816542 3095043 Regulation PDCD5 TNF 16584110 630400 Regulation PDCD5 TNF 9653098 1603168 Regulation PDCD6 CAPN8 16776830 383366 Regulation PDCD6 CCND1 23606879 818618 Regulation PDCD6 FAS 21088713 1044790 Regulation PDCD6 FAS 24025186 367198 Regulation PDCD6 FAS 9126933 1601092 Regulation PDCD6 MMP28 11250717 456933 Regulation PDCD6 MMP7 11250717 456948 Regulation PDCD6 TNF 11720454 420201 Regulation PDCD6 TNF 12816542 3095044 Regulation PDCD6 TNF 16584110 630401 Regulation PDCD6 TNF 9653098 1603169 Regulation PDCD7 CAPN8 16776830 383381 Regulation PDCD7 CCND1 23606879 818619 Regulation PDCD7 FAS 21088713 1044791 Regulation PDCD7 FAS 24025186 367199 Regulation PDCD7 FAS 9126933 1601094 Regulation PDCD7 MMP28 11250717 456955 Regulation PDCD7 MMP7 11250717 456970 Regulation PDCD7 TNF 11720454 420202 Regulation PDCD7 TNF 12816542 3095045 Regulation PDCD7 TNF 16584110 630402 Regulation PDCD7 TNF 9653098 1603170 Regulation PDE3A CAPN8 PMC3363253 391259 Regulation PDE4B IL2 23451206 2758368 Regulation PDE4B IL2 23451206 2758371 Regulation PDE4B KRAS 22830422 1866255 Regulation PDE4B TLR4 23888251 696993 Regulation PDE5A WNT3A 25429621 579485 Regulation PDE6D CTGF 20979602 3111544 Regulation PDGFB EPHB2 21738771 2533811 Regulation PDGFRA EPHB2 24489888 2916678 Regulation PDGFRA EPHB2 24489888 2916679 Regulation PDGFRA MAP2K6 24489888 2916675 Regulation PDGFRA MAP2K6 24489888 2916685 Regulation PDGFRB MAP2K6 21496277 259540 Regulation PDGFRB TNFSF10 24999473 194213 Regulation PDK1 EPHB2 24265727 2885087 Regulation PDK1 FOXO1 23130316 730589 Regulation PDK2 FOXO1 23130316 730593 Regulation PDK3 FOXO1 23130316 730597 Regulation PDK4 EPHB2 23961260 1243175 Regulation PDK4 FOXO1 22489168 1095513 Regulation PDK4 FOXO1 23130316 730601 Regulation PDK4 FOXO1 23443131 1102642 Regulation PDK4 FOXO1 24520982 2113977 Regulation PDK4 FOXO1 PMC3757848 3086644 Regulation PDK4 PGC 22682013 2113235 Regulation PDK4 PGC 23716639 2088910 Regulation PDK4 PGC 24466039 2912188 Regulation PDLIM7 ID1 21701587 2531206 Regulation PDLIM7 ID1 21701587 2531210 Regulation PDLIM7 ID1 21701587 2531217 Regulation PDLIM7 TLR7 22952664 2683538 Regulation PDLIM7 TLR7 22952664 2683564 Regulation PDX1 FOXO1 21537415 730257 Regulation PDX1 FOXO1 21716694 831712 Regulation PDX1 FOXO1 22110478 832196 Regulation PDX1 FOXO1 22577380 1072978 Regulation PDX1 FOXO1 23424659 2755180 Regulation PDX1 PGC 23274887 725452 Regulation PDX1 PGC 23274887 725453 Regulation PDX1 PGC 23274887 725454 Regulation PDX1 PGC 23274887 725475 Regulation PDZK1 PPARA 20090896 1020654 Regulation PDZK1 SCARB1 20949066 3048888 Regulation PDZK1 SCARB1 23936087 2829384 Regulation PECAM1 CCL2 22641100 1718352 Regulation PECAM1 CCL2 22641100 1718353 Regulation PECAM1 CCL2 22641100 1718354 Regulation PECAM1 CCL2 22641100 1718364 Regulation PECAM1 CCL2 22641100 1718365 Regulation PECAM1 CCL2 22641100 1718376 Regulation PECAM1 CCL2 22641100 1718377 Regulation PECAM1 CCL2 22641100 1718388 Regulation PECAM1 CCL2 22641100 1718396 Regulation PECAM1 CD38 23946809 2165404 Regulation PECAM1 CDH1 22646479 336552 Regulation PECAM1 CDH10 22646479 336553 Regulation PECAM1 CDH11 22646479 336554 Regulation PECAM1 CDH12 22646479 336555 Regulation PECAM1 CDH13 22646479 336556 Regulation PECAM1 CDH15 22646479 336557 Regulation PECAM1 CDH16 22646479 336558 Regulation PECAM1 CDH17 22646479 336559 Regulation PECAM1 CDH18 22646479 336560 Regulation PECAM1 CDH19 22646479 336561 Regulation PECAM1 CDH2 22646479 336562 Regulation PECAM1 CDH20 22646479 336563 Regulation PECAM1 CDH22 22646479 336548 Regulation PECAM1 CDH23 22646479 336549 Regulation PECAM1 CDH24 22646479 336550 Regulation PECAM1 CDH26 22646479 336551 Regulation PECAM1 CDH3 22646479 336564 Regulation PECAM1 CDH4 22646479 336565 Regulation PECAM1 CDH5 22646479 336566 Regulation PECAM1 CDH5 24665386 3178739 Regulation PECAM1 CDH6 22646479 336567 Regulation PECAM1 CDH7 22646479 336568 Regulation PECAM1 CDH8 22646479 336569 Regulation PECAM1 CDH9 22646479 336570 Regulation PECAM1 DAPK3 23279263 1653560 Regulation PECAM1 DBT 22927877 815044 Regulation PECAM1 ENG 8655583 1451941 Regulation PECAM1 FER 18710921 1354885 Regulation PECAM1 FYN 18710921 1354886 Regulation PECAM1 FYN 18710921 1354895 Regulation PECAM1 GATA2 18498633 323671 Regulation PECAM1 HGF 23622716 1617868 Regulation PECAM1 KMT2A 22926525 2148342 Regulation PECAM1 MAP2K1 24939055 1508122 Regulation PECAM1 MAP2K2 24939055 1508123 Regulation PECAM1 MAP2K3 24939055 1508124 Regulation PECAM1 MAP2K4 24939055 1508125 Regulation PECAM1 MAP2K5 24939055 1508126 Regulation PECAM1 MAP2K6 24939055 1508127 Regulation PECAM1 MAP2K7 24939055 1508128 Regulation PECAM1 MBTPS1 24898615 1234116 Regulation PECAM1 MTOR 24939055 1508121 Regulation PECAM1 MYLIP 22646479 336571 Regulation PECAM1 NA 22927877 815045 Regulation PECAM1 OLFM1 23264563 739820 Regulation PECAM1 PRKCD 25084151 2994182 Regulation PECAM1 PRKCE 25084151 2994169 Regulation PECAM1 PRKCE 25084151 2994183 Regulation PECAM1 SRC 22641100 1718355 Regulation PECAM1 SRC 22641100 1718384 Regulation PECAM1 SRC 22641100 1718391 Regulation PECAM1 TBX5 12177047 1286367 Regulation PECAM1 TP53 16982804 1334098 Regulation PER1 FAS 24068941 2349955 Regulation PER1 RGS16 21610730 1933106 Regulation PER1 TNF 24901009 1621707 Regulation PER1 TNF 25397888 3027402 Regulation PER2 TNF 24901009 1621717 Regulation PGC ADIPOQ 20929977 716673 Regulation PGC ADIPOQ 23238294 725379 Regulation PGC ADO 24914683 2978948 Regulation PGC AGTR2 19074984 707532 Regulation PGC AKT1 22415879 722091 Regulation PGC AKT1 23110128 2706571 Regulation PGC AKT1 24675698 1125672 Regulation PGC AKT1S1 20299475 713304 Regulation PGC AKT1S1 23497627 3161799 Regulation PGC AKT2 22415879 722092 Regulation PGC AKT2 23110128 2706572 Regulation PGC AKT3 22415879 722093 Regulation PGC AKT3 23110128 2706573 Regulation PGC ARNTL 21483791 2512232 Regulation PGC ATP4A 22448266 2613423 Regulation PGC BMP2 22549226 788623 Regulation PGC BMP4 19107197 2402702 Regulation PGC BMP4 22549226 788624 Regulation PGC BMP7 22549226 788625 Regulation PGC CA2 20847946 3075431 Regulation PGC CA2 23028640 2692006 Regulation PGC CA2 24027504 861018 Regulation PGC CA2 25072597 2992994 Regulation PGC CAPS 23968387 2233544 Regulation PGC CCNT1 22096235 2069573 Regulation PGC CCNT1 22096235 2069578 Regulation PGC CCNT2 22096235 2069579 Regulation PGC CDK9 17389765 3071518 Regulation PGC CEBPA 19641492 1983875 Regulation PGC CIDEC 18682832 2394923 Regulation PGC CPT1A 21915347 2553456 Regulation PGC CREB1 21542802 137817 Regulation PGC CREB1 22288011 2009384 Regulation PGC CREB1 22508755 2074770 Regulation PGC CREB1 22540007 2623095 Regulation PGC CREB1 22540007 2623100 Regulation PGC CREB1 22829833 1068703 Regulation PGC CREB1 25493285 88060 Regulation PGC CREB3 21542802 137818 Regulation PGC CREB3 22288011 2009385 Regulation PGC CREB3 22508755 2074771 Regulation PGC CREB3 22540007 2623096 Regulation PGC CREB3 22540007 2623101 Regulation PGC CREB3 22829833 1068704 Regulation PGC CREB3 25493285 88061 Regulation PGC CREB5 21542802 137816 Regulation PGC CREB5 22288011 2009383 Regulation PGC CREB5 22508755 2074769 Regulation PGC CREB5 22540007 2623094 Regulation PGC CREB5 22540007 2623099 Regulation PGC CREB5 22829833 1068702 Regulation PGC CREB5 25493285 88059 Regulation PGC CTBP1 22453831 1933649 Regulation PGC CTBP1 22453831 1933662 Regulation PGC CTBP1 22453831 1933676 Regulation PGC CTDNEP1 23469192 2763027 Regulation PGC CTDNEP1 23469192 2763122 Regulation PGC DGAT1 21264296 2495226 Regulation PGC DGAT1 21264296 2495227 Regulation PGC DUSP1 22415879 721908 Regulation PGC DUSP1 22415879 722090 Regulation PGC DUSP1 22415879 722251 Regulation PGC EPO 25170305 1063283 Regulation PGC EPX 23990359 728519 Regulation PGC EPX 25170305 1063351 Regulation PGC EPX 25170305 1063371 Regulation PGC ERF 20713602 1378392 Regulation PGC ESRRA 24904222 491417 Regulation PGC FAS 22676303 1724599 Regulation PGC FGF1 24917499 704134 Regulation PGC FGF10 24917499 704135 Regulation PGC FGF11 24917499 704136 Regulation PGC FGF12 24917499 704137 Regulation PGC FGF13 24917499 704138 Regulation PGC FGF14 24917499 704139 Regulation PGC FGF16 24917499 704140 Regulation PGC FGF17 24917499 704141 Regulation PGC FGF18 24917499 704142 Regulation PGC FGF19 24917499 704143 Regulation PGC FGF2 24917499 704144 Regulation PGC FGF20 24917499 704145 Regulation PGC FGF21 23970879 879138 Regulation PGC FGF21 24917499 704146 Regulation PGC FGF22 24917499 704147 Regulation PGC FGF23 24917499 704148 Regulation PGC FGF3 24917499 704149 Regulation PGC FGF4 24917499 704150 Regulation PGC FGF5 24917499 704151 Regulation PGC FGF6 24917499 704152 Regulation PGC FGF7 24917499 704153 Regulation PGC FGF8 24917499 704154 Regulation PGC FGF9 24917499 704155 Regulation PGC FNDC5 PMC3374209 395681 Regulation PGC FOXC2 21270254 717391 Regulation PGC FOXC2 21270254 717399 Regulation PGC FOXO6 23639108 213498 Regulation PGC FOXO6 23639108 213499 Regulation PGC FOXO6 23639108 213503 Regulation PGC FOXO6 23639108 213511 Regulation PGC GAPDH 20972425 1925268 Regulation PGC GATA1 18974883 2399624 Regulation PGC GATA2 18974883 2399625 Regulation PGC GATA3 18974883 2399626 Regulation PGC GATA4 18974883 2399627 Regulation PGC GATA4 18974883 2399628 Regulation PGC GATA5 18974883 2399623 Regulation PGC GATA6 18974883 2399629 Regulation PGC GCG 24733293 2952839 Regulation PGC GDF5 22549226 788626 Regulation PGC GDF6 22549226 788627 Regulation PGC GDF7 22549226 788628 Regulation PGC HDAC1 21731503 2324981 Regulation PGC HDAC1 22453831 1933653 Regulation PGC HDAC1 22453831 1933666 Regulation PGC HDAC1 22453831 1933680 Regulation PGC HDAC10 21731503 2324979 Regulation PGC HDAC11 21731503 2324980 Regulation PGC HDAC2 21731503 2324982 Regulation PGC HDAC2 22453831 1933667 Regulation PGC HDAC3 21731503 2324983 Regulation PGC HDAC3 23069623 724952 Regulation PGC HDAC4 21731503 2324973 Regulation PGC HDAC5 18974883 2399720 Regulation PGC HDAC5 21731503 2324977 Regulation PGC HDAC6 21731503 2324974 Regulation PGC HDAC7 21731503 2324976 Regulation PGC HDAC8 21731503 2324972 Regulation PGC HDAC9 21731503 2324975 Regulation PGC HMG20A 22453831 1933654 Regulation PGC HMG20A 22453831 1933668 Regulation PGC HMG20A 22453831 1933681 Regulation PGC HMG20B 22453831 1933655 Regulation PGC HMG20B 22453831 1933669 Regulation PGC HMG20B 22453831 1933682 Regulation PGC HSPA1B 22453831 1933656 Regulation PGC HSPA1B 22453831 1933670 Regulation PGC HSPA1B 22453831 1933683 Regulation PGC IL6 23240005 2727162 Regulation PGC IL6 23240005 2727163 Regulation PGC IL6 23240005 2727172 Regulation PGC IL6 23240005 2727177 Regulation PGC IL6 23240005 2727178 Regulation PGC IL6 23240005 2727179 Regulation PGC IL6 23240005 2727187 Regulation PGC IL6ST 17389765 3071519 Regulation PGC INS 19262749 2406890 Regulation PGC KAT2A 21629705 1155240 Regulation PGC KAT2A 25186010 83611 Regulation PGC KAT2B 21493629 1033413 Regulation PGC KAT2B 23434656 1101839 Regulation PGC KDM1A 22453831 1933652 Regulation PGC KDM1A 22453831 1933665 Regulation PGC KDM1A 22453831 1933679 Regulation PGC KLF11 24586865 2927368 Regulation PGC LEP 20929977 716674 Regulation PGC LEP 20929977 716675 Regulation PGC MAF 23922719 2826261 Regulation PGC MAPK1 20847946 3075408 Regulation PGC MAPK1 22175016 1686904 Regulation PGC MAPK1 22415879 722284 Regulation PGC MAPK1 23554809 3076547 Regulation PGC MAPK10 20847946 3075409 Regulation PGC MAPK10 22175016 1686905 Regulation PGC MAPK10 22415879 722285 Regulation PGC MAPK10 23554809 3076548 Regulation PGC MAPK11 20847946 3075410 Regulation PGC MAPK11 22175016 1686906 Regulation PGC MAPK11 22415879 722286 Regulation PGC MAPK11 23554809 3076549 Regulation PGC MAPK12 20847946 3075411 Regulation PGC MAPK12 22175016 1686907 Regulation PGC MAPK12 22415879 722287 Regulation PGC MAPK12 23554809 3076550 Regulation PGC MAPK13 20847946 3075412 Regulation PGC MAPK13 22175016 1686908 Regulation PGC MAPK13 22415879 722288 Regulation PGC MAPK13 23554809 3076551 Regulation PGC MAPK14 20847946 3075413 Regulation PGC MAPK14 22175016 1686909 Regulation PGC MAPK14 22415879 722289 Regulation PGC MAPK14 23554809 3076552 Regulation PGC MAPK15 20847946 3075407 Regulation PGC MAPK15 22175016 1686903 Regulation PGC MAPK15 22415879 722283 Regulation PGC MAPK15 23554809 3076546 Regulation PGC MAPK3 20847946 3075414 Regulation PGC MAPK3 22175016 1686910 Regulation PGC MAPK3 22415879 722290 Regulation PGC MAPK3 23554809 3076553 Regulation PGC MAPK4 20847946 3075415 Regulation PGC MAPK4 22175016 1686911 Regulation PGC MAPK4 22415879 722291 Regulation PGC MAPK4 23554809 3076554 Regulation PGC MAPK6 20847946 3075416 Regulation PGC MAPK6 22175016 1686912 Regulation PGC MAPK6 22415879 722292 Regulation PGC MAPK6 23554809 3076555 Regulation PGC MAPK7 20847946 3075417 Regulation PGC MAPK7 22175016 1686913 Regulation PGC MAPK7 22415879 722293 Regulation PGC MAPK7 23554809 3076556 Regulation PGC MAPK8 20847946 3075418 Regulation PGC MAPK8 22175016 1686914 Regulation PGC MAPK8 22415879 722294 Regulation PGC MAPK8 23554809 3076557 Regulation PGC MAPK9 20847946 3075419 Regulation PGC MAPK9 22175016 1686915 Regulation PGC MAPK9 22415879 722295 Regulation PGC MAPK9 23554809 3076558 Regulation PGC MARK1 25057490 195438 Regulation PGC MARK2 25057490 195437 Regulation PGC MARK3 25057490 195439 Regulation PGC MARK4 25057490 195436 Regulation PGC MFN1 24642777 2935275 Regulation PGC MFN2 24623376 784461 Regulation PGC MFN2 24642777 2935274 Regulation PGC MITF 24161908 2185154 Regulation PGC MLST8 20299475 713303 Regulation PGC MLST8 23497627 3161798 Regulation PGC MPST 25364764 862512 Regulation PGC MPZ 22622131 555555 Regulation PGC MPZ 22742579 292133 Regulation PGC MSH6 22548174 1155571 Regulation PGC MTOR 20299475 713306 Regulation PGC MTOR 22351927 1395771 Regulation PGC MTOR 22351927 1395773 Regulation PGC MTOR 22351927 1395779 Regulation PGC MTOR 22771762 842572 Regulation PGC MTOR 23434656 1101873 Regulation PGC MTOR 23497627 3161797 Regulation PGC MTOR 23497627 3161801 Regulation PGC MYC 19779629 2427292 Regulation PGC MYLIP 19440340 2416802 Regulation PGC MYLIP 20724363 1682596 Regulation PGC MYLIP 24086656 2855440 Regulation PGC MYLIP 24705162 985143 Regulation PGC NAMPT 25566462 1498464 Regulation PGC NOS3 22802954 2663779 Regulation PGC NRD1 24492630 1940589 Regulation PGC NRD1 24492630 1940590 Regulation PGC NRD1 24492630 1940591 Regulation PGC NRD1 24492630 1940597 Regulation PGC NRD1 24492630 1940611 Regulation PGC NRD1 24492630 1940612 Regulation PGC NRIP1 22389706 2608012 Regulation PGC PHF21A 22453831 1933648 Regulation PGC PHF21A 22453831 1933661 Regulation PGC PHF21A 22453831 1933675 Regulation PGC PHF21B 22453831 1933650 Regulation PGC PHF21B 22453831 1933663 Regulation PGC PHF21B 22453831 1933677 Regulation PGC PI3 24675698 1125673 Regulation PGC POU5F1 21547058 1057112 Regulation PGC PPARA 21723506 590230 Regulation PGC PPARA 21723506 590232 Regulation PGC PPP3CA 23431467 1151214 Regulation PGC PPP3R1 23431467 1151215 Regulation PGC PRDM16 19641492 1983874 Regulation PGC PRKAA1 18974883 2399630 Regulation PGC PRKAA1 18974883 2399666 Regulation PGC PRKAA1 18974883 2399667 Regulation PGC PRKAA1 18974883 2399721 Regulation PGC PRKAA1 19502419 708810 Regulation PGC PRKAA1 21040371 174503 Regulation PGC PRKAA1 21768291 1390000 Regulation PGC PRKAA1 22175016 1686916 Regulation PGC PRKAA1 22353542 2113168 Regulation PGC PRKAA1 22359576 2597769 Regulation PGC PRKAA1 22808092 2664291 Regulation PGC PRKAA1 22837722 1096667 Regulation PGC PRKAA1 23304112 3076110 Regulation PGC PRKAA1 23755172 2801618 Regulation PGC PRKAA1 23964012 781876 Regulation PGC PRKAA1 24296486 31737 Regulation PGC PRKAA1 24296486 31863 Regulation PGC PRKAA1 24624081 858853 Regulation PGC PRKAA1 24801481 2961417 Regulation PGC PRKAA1 24822191 190566 Regulation PGC PRKAA1 24843073 2252151 Regulation PGC PRKAA1 25026276 2195907 Regulation PGC PRKAA1 25057490 195440 Regulation PGC PRKAA1 25136584 197207 Regulation PGC PRKAA1 25170305 1063335 Regulation PGC PRKAA1 25566462 1498489 Regulation PGC PRKAA1 25566462 1498495 Regulation PGC PRKAA2 18974883 2399631 Regulation PGC PRKAA2 18974883 2399668 Regulation PGC PRKAA2 18974883 2399669 Regulation PGC PRKAA2 18974883 2399722 Regulation PGC PRKAA2 19502419 708811 Regulation PGC PRKAA2 21040371 174504 Regulation PGC PRKAA2 21768291 1390001 Regulation PGC PRKAA2 22175016 1686917 Regulation PGC PRKAA2 22353542 2113169 Regulation PGC PRKAA2 22359576 2597770 Regulation PGC PRKAA2 22808092 2664292 Regulation PGC PRKAA2 22837722 1096668 Regulation PGC PRKAA2 23304112 3076111 Regulation PGC PRKAA2 23755172 2801619 Regulation PGC PRKAA2 23964012 781877 Regulation PGC PRKAA2 24296486 31738 Regulation PGC PRKAA2 24296486 31864 Regulation PGC PRKAA2 24624081 858854 Regulation PGC PRKAA2 24801481 2961418 Regulation PGC PRKAA2 24822191 190567 Regulation PGC PRKAA2 24843073 2252152 Regulation PGC PRKAA2 25026276 2195908 Regulation PGC PRKAA2 25057490 195441 Regulation PGC PRKAA2 25136584 197208 Regulation PGC PRKAA2 25170305 1063336 Regulation PGC PRKAA2 25566462 1498490 Regulation PGC PRKAA2 25566462 1498496 Regulation PGC PRKAB1 18974883 2399632 Regulation PGC PRKAB1 18974883 2399670 Regulation PGC PRKAB1 18974883 2399671 Regulation PGC PRKAB1 18974883 2399723 Regulation PGC PRKAB1 19502419 708812 Regulation PGC PRKAB1 21040371 174505 Regulation PGC PRKAB1 21768291 1390002 Regulation PGC PRKAB1 22175016 1686918 Regulation PGC PRKAB1 22353542 2113170 Regulation PGC PRKAB1 22359576 2597771 Regulation PGC PRKAB1 22808092 2664293 Regulation PGC PRKAB1 22837722 1096669 Regulation PGC PRKAB1 23304112 3076112 Regulation PGC PRKAB1 23755172 2801620 Regulation PGC PRKAB1 23964012 781878 Regulation PGC PRKAB1 24296486 31739 Regulation PGC PRKAB1 24296486 31865 Regulation PGC PRKAB1 24624081 858855 Regulation PGC PRKAB1 24801481 2961419 Regulation PGC PRKAB1 24822191 190568 Regulation PGC PRKAB1 24843073 2252153 Regulation PGC PRKAB1 25026276 2195909 Regulation PGC PRKAB1 25057490 195442 Regulation PGC PRKAB1 25136584 197209 Regulation PGC PRKAB1 25170305 1063337 Regulation PGC PRKAB1 25566462 1498491 Regulation PGC PRKAB1 25566462 1498497 Regulation PGC PRKAB2 18974883 2399633 Regulation PGC PRKAB2 18974883 2399672 Regulation PGC PRKAB2 18974883 2399673 Regulation PGC PRKAB2 18974883 2399724 Regulation PGC PRKAB2 19502419 708813 Regulation PGC PRKAB2 21040371 174506 Regulation PGC PRKAB2 21768291 1390003 Regulation PGC PRKAB2 22175016 1686919 Regulation PGC PRKAB2 22353542 2113171 Regulation PGC PRKAB2 22359576 2597772 Regulation PGC PRKAB2 22808092 2664294 Regulation PGC PRKAB2 22837722 1096670 Regulation PGC PRKAB2 23304112 3076113 Regulation PGC PRKAB2 23755172 2801621 Regulation PGC PRKAB2 23964012 781879 Regulation PGC PRKAB2 24296486 31740 Regulation PGC PRKAB2 24296486 31866 Regulation PGC PRKAB2 24624081 858856 Regulation PGC PRKAB2 24801481 2961420 Regulation PGC PRKAB2 24822191 190569 Regulation PGC PRKAB2 24843073 2252154 Regulation PGC PRKAB2 25026276 2195910 Regulation PGC PRKAB2 25057490 195443 Regulation PGC PRKAB2 25136584 197210 Regulation PGC PRKAB2 25170305 1063338 Regulation PGC PRKAB2 25566462 1498492 Regulation PGC PRKAB2 25566462 1498498 Regulation PGC PRKACB 19502419 708814 Regulation PGC PRKACB 22500113 1224027 Regulation PGC PRKACB 22500113 1224045 Regulation PGC PRKACB 23554809 3076672 Regulation PGC PRKACB 24642777 2935276 Regulation PGC PRKACG 19502419 708815 Regulation PGC PRKACG 22500113 1224028 Regulation PGC PRKACG 22500113 1224046 Regulation PGC PRKACG 23554809 3076673 Regulation PGC PRKACG 24642777 2935277 Regulation PGC PRKAG1 18974883 2399634 Regulation PGC PRKAG1 18974883 2399674 Regulation PGC PRKAG1 18974883 2399675 Regulation PGC PRKAG1 18974883 2399725 Regulation PGC PRKAG1 19502419 708816 Regulation PGC PRKAG1 21040371 174507 Regulation PGC PRKAG1 21768291 1390004 Regulation PGC PRKAG1 22175016 1686920 Regulation PGC PRKAG1 22353542 2113172 Regulation PGC PRKAG1 22359576 2597773 Regulation PGC PRKAG1 22808092 2664295 Regulation PGC PRKAG1 22837722 1096671 Regulation PGC PRKAG1 23304112 3076114 Regulation PGC PRKAG1 23755172 2801622 Regulation PGC PRKAG1 23964012 781880 Regulation PGC PRKAG1 24296486 31741 Regulation PGC PRKAG1 24296486 31867 Regulation PGC PRKAG1 24624081 858857 Regulation PGC PRKAG1 24801481 2961421 Regulation PGC PRKAG1 24822191 190570 Regulation PGC PRKAG1 24843073 2252155 Regulation PGC PRKAG1 25026276 2195911 Regulation PGC PRKAG1 25057490 195444 Regulation PGC PRKAG1 25136584 197211 Regulation PGC PRKAG1 25170305 1063339 Regulation PGC PRKAG1 25566462 1498493 Regulation PGC PRKAG1 25566462 1498499 Regulation PGC PRKAG2 18974883 2399635 Regulation PGC PRKAG2 18974883 2399676 Regulation PGC PRKAG2 18974883 2399677 Regulation PGC PRKAG2 18974883 2399726 Regulation PGC PRKAG2 19502419 708817 Regulation PGC PRKAG2 21040371 174508 Regulation PGC PRKAG2 21768291 1390005 Regulation PGC PRKAG2 22175016 1686921 Regulation PGC PRKAG2 22353542 2113173 Regulation PGC PRKAG2 22359576 2597774 Regulation PGC PRKAG2 22808092 2664296 Regulation PGC PRKAG2 22837722 1096672 Regulation PGC PRKAG2 23304112 3076115 Regulation PGC PRKAG2 23755172 2801623 Regulation PGC PRKAG2 23964012 781881 Regulation PGC PRKAG2 24296486 31742 Regulation PGC PRKAG2 24296486 31868 Regulation PGC PRKAG2 24624081 858858 Regulation PGC PRKAG2 24801481 2961422 Regulation PGC PRKAG2 24822191 190571 Regulation PGC PRKAG2 24843073 2252156 Regulation PGC PRKAG2 25026276 2195912 Regulation PGC PRKAG2 25057490 195445 Regulation PGC PRKAG2 25136584 197212 Regulation PGC PRKAG2 25170305 1063340 Regulation PGC PRKAG2 25566462 1498494 Regulation PGC PRKAG2 25566462 1498500 Regulation PGC PRKAR1A 19502419 708818 Regulation PGC PRKAR1A 22500113 1224029 Regulation PGC PRKAR1A 22500113 1224047 Regulation PGC PRKAR1A 23554809 3076674 Regulation PGC PRKAR1A 24642777 2935278 Regulation PGC PRKAR1B 19502419 708819 Regulation PGC PRKAR1B 22500113 1224030 Regulation PGC PRKAR1B 22500113 1224048 Regulation PGC PRKAR1B 23554809 3076675 Regulation PGC PRKAR1B 24642777 2935279 Regulation PGC PRKAR2A 19502419 708820 Regulation PGC PRKAR2A 22500113 1224031 Regulation PGC PRKAR2A 22500113 1224049 Regulation PGC PRKAR2A 23554809 3076676 Regulation PGC PRKAR2A 24642777 2935280 Regulation PGC PRKAR2B 19502419 708821 Regulation PGC PRKAR2B 22500113 1224032 Regulation PGC PRKAR2B 22500113 1224050 Regulation PGC PRKAR2B 23554809 3076677 Regulation PGC PRKAR2B 24642777 2935281 Regulation PGC RB1 23895241 213830 Regulation PGC RBL1 20713602 1378393 Regulation PGC RBL1 20713602 1378394 Regulation PGC RBL1 20713602 1378395 Regulation PGC RBL1 20713602 1378396 Regulation PGC RBL1 20713602 1378397 Regulation PGC RBL1 20713602 1378403 Regulation PGC RBL1 20713602 1378404 Regulation PGC RCOR1 22453831 1933647 Regulation PGC RCOR1 22453831 1933660 Regulation PGC RCOR1 22453831 1933674 Regulation PGC RCOR3 22453831 1933651 Regulation PGC RCOR3 22453831 1933664 Regulation PGC RCOR3 22453831 1933678 Regulation PGC RELB 24472138 1727086 Regulation PGC RNF19A 21040371 174502 Regulation PGC RPS6KA5 21493629 1033409 Regulation PGC RPS6KB1 20299475 713302 Regulation PGC RPTOR 20299475 713305 Regulation PGC RPTOR 23497627 3161800 Regulation PGC RREB1 22453831 1933644 Regulation PGC RREB1 22453831 1933657 Regulation PGC RREB1 22453831 1933671 Regulation PGC RUNX2 24983969 2985858 Regulation PGC SETD2 21437130 731295 Regulation PGC SIRT1 18031569 32514 Regulation PGC SIRT1 18031569 32515 Regulation PGC SIRT1 18031569 32517 Regulation PGC SIRT1 19247483 2406595 Regulation PGC SIRT1 19500359 2112541 Regulation PGC SIRT1 20157548 25883 Regulation PGC SIRT1 20847946 3075191 Regulation PGC SIRT1 21483036 29430 Regulation PGC SIRT1 21525818 1734951 Regulation PGC SIRT1 21596782 2063186 Regulation PGC SIRT1 21731503 2324978 Regulation PGC SIRT1 22096235 2069572 Regulation PGC SIRT1 22096235 2069577 Regulation PGC SIRT1 22447225 14606 Regulation PGC SIRT1 22447225 14630 Regulation PGC SIRT1 22548174 1155561 Regulation PGC SIRT1 23755172 2801617 Regulation PGC SIRT1 23874150 2283636 Regulation PGC SIRT1 23874150 2283726 Regulation PGC SIRT1 24505445 2920900 Regulation PGC SIRT1 24742694 2188990 Regulation PGC SIRT1 24822191 190565 Regulation PGC SIRT1 25032964 2360451 Regulation PGC SIRT1 25057490 195419 Regulation PGC SIRT1 25170305 1063282 Regulation PGC SIRT1 25192192 2245337 Regulation PGC SIRT6 24015318 2842828 Regulation PGC SLC25A5 24296486 31736 Regulation PGC SLC2A4 22359576 2597744 Regulation PGC SLC7A1 20661474 2456755 Regulation PGC SOX2 22737227 2655691 Regulation PGC STK11 21124456 1986876 Regulation PGC TACC2 21493629 1033411 Regulation PGC TACC3 21493629 1033412 Regulation PGC TAF4 22288011 2009382 Regulation PGC TANK 23342071 2741978 Regulation PGC TCF12 24161908 2185143 Regulation PGC TCF15 24161908 2185144 Regulation PGC TCF19 24161908 2185145 Regulation PGC TCF20 24161908 2185146 Regulation PGC TCF21 24161908 2185147 Regulation PGC TCF23 24161908 2185151 Regulation PGC TCF24 24161908 2185153 Regulation PGC TCF25 24161908 2185152 Regulation PGC TCF3 24161908 2185148 Regulation PGC TCF4 24161908 2185149 Regulation PGC TCF7 24161908 2185150 Regulation PGC TDRD7 23777831 828378 Regulation PGC TET2 24322296 2096635 Regulation PGC TET3 24322296 2096636 Regulation PGC TFAM 23755172 2801583 Regulation PGC TFAM 24344687 2221662 Regulation PGC TFEB 25061009 3203852 Regulation PGC TNF 22082477 682664 Regulation PGC TNFRSF12A 23342071 2741979 Regulation PGC TNFSF12 22082477 682662 Regulation PGC TNFSF12 23342071 2741982 Regulation PGC TNFSF12 23835416 3163176 Regulation PGC TNFSF12 23835416 3163177 Regulation PGC TNFSF12 23835416 3163180 Regulation PGC TP53 20042072 328071 Regulation PGC TWIST1 23093952 3075996 Regulation PGC TWIST1 23093952 3075997 Regulation PGC TWIST1 23093952 3075998 Regulation PGC TWIST1 23093952 3076028 Regulation PGC TWIST1 23093952 3076029 Regulation PGC TWIST1 23093952 3076038 Regulation PGC TWIST1 23093952 3076039 Regulation PGC TWIST1 23093952 3076072 Regulation PGC UCP1 20885954 2475678 Regulation PGC UCP1 23554809 3076637 Regulation PGC UCP2 25152028 19616 Regulation PGC UGCG 23274887 725455 Regulation PGC USF1 18974883 2399622 Regulation PGC USF1 18974883 2399665 Regulation PGC WNT1 23469192 2763033 Regulation PGC WNT11 23469192 2763034 Regulation PGC WNT16 23469192 2763039 Regulation PGC WNT2 23469192 2763035 Regulation PGC WNT3 23469192 2763036 Regulation PGC WNT4 23469192 2763037 Regulation PGC WNT6 23469192 2763038 Regulation PGC ZMYM2 22453831 1933645 Regulation PGC ZMYM2 22453831 1933658 Regulation PGC ZMYM2 22453831 1933672 Regulation PGC ZNF217 22453831 1933646 Regulation PGC ZNF217 22453831 1933659 Regulation PGC ZNF217 22453831 1933673 Regulation PGC ZNF746 21708898 739041 Regulation PGC ZNF746 21708898 739042 Regulation PGD IL1B 9836494 1764020 Regulation PGD IL1B 9836494 1764021 Regulation PGF ARSA 24672263 650221 Regulation PGF TNF 20064200 118109 Regulation PGF TNF 24663124 2938006 Regulation PGP EPHB2 23799854 440985 Regulation PGP EPHB2 23799854 440989 Regulation PGP MMP28 19450278 3109572 Regulation PGP MMP7 19450278 3109588 Regulation PGP TNF 20300455 1214077 Regulation PGP TNF 20300455 1214082 Regulation PGP TNF 20300455 1214089 Regulation PGP TNF 24130926 204543 Regulation PGP TNF 24130926 204548 Regulation PGP TNF 24130926 204549 Regulation PGP TNF 24130926 204551 Regulation PGP TNF 24498193 2918890 Regulation PGR CCND1 24575359 86190 Regulation PHC1 EPHB2 22870894 802978 Regulation PHF5A SMN2 22110043 2070054 Regulation PHLDA1 EPHB2 18597688 251139 Regulation PHYH PGC 25610371 872921 Regulation PI3 ANGPT1 16584574 279147 Regulation PI3 ANGPT1 25329960 3017072 Regulation PI3 PRODH 25628629 972047 Regulation PI3 TLR7 17371930 1545009 Regulation PIAS2 TNF 23525087 1958676 Regulation PIGR ARR3 19476633 365675 Regulation PIGR ERVK-6 20706611 1216015 Regulation PIGR IL17A 24220295 1920126 Regulation PIGR IL1A 21956244 1918516 Regulation PIGR IL1A 24220295 1920127 Regulation PIGR MAPK1 21451502 1918356 Regulation PIGR MAPK10 21451502 1918357 Regulation PIGR MAPK11 21451502 1918358 Regulation PIGR MAPK12 21451502 1918359 Regulation PIGR MAPK13 21451502 1918360 Regulation PIGR MAPK14 21451502 1918361 Regulation PIGR MAPK15 21451502 1918355 Regulation PIGR MAPK3 21451502 1918362 Regulation PIGR MAPK4 21451502 1918363 Regulation PIGR MAPK6 21451502 1918364 Regulation PIGR MAPK7 21451502 1918365 Regulation PIGR MAPK8 21451502 1918366 Regulation PIGR MAPK9 21451502 1918367 Regulation PIGR MYD88 22491177 1918757 Regulation PIGR PIGQ 19476633 365674 Regulation PIGR SLPI 20706611 1216012 Regulation PIGR TLR1 21451502 1918203 Regulation PIGR TLR1 21451502 1918339 Regulation PIGR TLR1 22491177 1918745 Regulation PIGR TLR10 21451502 1918211 Regulation PIGR TLR10 21451502 1918348 Regulation PIGR TLR10 22491177 1918753 Regulation PIGR TLR2 21451502 1918204 Regulation PIGR TLR2 21451502 1918340 Regulation PIGR TLR2 22491177 1918746 Regulation PIGR TLR3 21451502 1918205 Regulation PIGR TLR3 21451502 1918341 Regulation PIGR TLR3 22491177 1918747 Regulation PIGR TLR3 24236214 2878963 Regulation PIGR TLR4 21451502 1918206 Regulation PIGR TLR4 21451502 1918342 Regulation PIGR TLR4 22491177 1918748 Regulation PIGR TLR5 21451502 1918207 Regulation PIGR TLR5 21451502 1918343 Regulation PIGR TLR5 22491177 1918749 Regulation PIGR TLR6 21451502 1918212 Regulation PIGR TLR6 21451502 1918349 Regulation PIGR TLR6 22491177 1918754 Regulation PIGR TLR7 21451502 1918208 Regulation PIGR TLR7 21451502 1918345 Regulation PIGR TLR7 22491177 1918750 Regulation PIGR TLR8 21451502 1918209 Regulation PIGR TLR8 21451502 1918346 Regulation PIGR TLR8 22491177 1918751 Regulation PIGR TLR9 21451502 1918210 Regulation PIGR TLR9 21451502 1918347 Regulation PIGR TLR9 22491177 1918752 Regulation PIGR TNF 21451502 1918344 Regulation PIK3C3 DAPK1 22095288 547712 Regulation PIK3CA CTGF 24637722 2934863 Regulation PIK3CA EPHB2 10747099 1257025 Regulation PIK3CA EPHB2 19357636 1902847 Regulation PIK3CA EPHB2 21762482 387037 Regulation PIK3CA EPHB2 23986484 1487119 Regulation PIK3CA EPHB2 23986484 1487120 Regulation PIK3CA EPHB2 23986484 1487157 Regulation PIK3CA FAS 21713032 2276559 Regulation PIK3CA FHL1 24952875 274075 Regulation PIK3CA FOXO1 20375467 27090 Regulation PIK3CA FOXO1 24162775 1959304 Regulation PIK3CA FOXO1 25488803 476395 Regulation PIK3CA INPP4B 22970424 941204 Regulation PIK3CA ITGB2 21232086 1657685 Regulation PIK3CA KANK4 18458160 1351943 Regulation PIK3CA KANK4 18458160 1352029 Regulation PIK3CA KANK4 18458160 1352069 Regulation PIK3CA LAMA4 19584916 1212753 Regulation PIK3CA LAMB3 18283320 430372 Regulation PIK3CA LAMB3 18283320 430383 Regulation PIK3CA MAP2K6 21762482 387043 Regulation PIK3CA MAP2K6 24263101 569228 Regulation PIK3CA MMP28 21799931 2539370 Regulation PIK3CA MMP7 21799931 2539386 Regulation PIK3CA OLFM4 25364714 861623 Regulation PIK3CA PECAM1 20723025 1692135 Regulation PIK3CA TLR7 22606294 2642943 Regulation PIK3CA TLR7 24740015 2954261 Regulation PIK3CA TM4SF19 25344917 2206279 Regulation PIK3CA TM4SF19 25344917 2206280 Regulation PIK3CA TNF 16504042 278995 Regulation PIK3CA TNF 22973314 1069067 Regulation PIK3CA TSPAN1 10491398 1249759 Regulation PIK3R1 CTGF 24637722 2934864 Regulation PIK3R1 EPHB2 10747099 1257026 Regulation PIK3R1 EPHB2 19357636 1902851 Regulation PIK3R1 EPHB2 21762482 387045 Regulation PIK3R1 EPHB2 23986484 1487121 Regulation PIK3R1 EPHB2 23986484 1487122 Regulation PIK3R1 EPHB2 23986484 1487158 Regulation PIK3R1 FAS 21713032 2276560 Regulation PIK3R1 FHL1 24952875 274076 Regulation PIK3R1 FOXO1 20375467 27094 Regulation PIK3R1 FOXO1 24162775 1959305 Regulation PIK3R1 FOXO1 25488803 476399 Regulation PIK3R1 INPP4B 22970424 941205 Regulation PIK3R1 ITGB2 21232086 1657686 Regulation PIK3R1 KANK4 18458160 1351947 Regulation PIK3R1 KANK4 18458160 1352033 Regulation PIK3R1 KANK4 18458160 1352073 Regulation PIK3R1 LAMA4 19584916 1212754 Regulation PIK3R1 LAMB3 18283320 430376 Regulation PIK3R1 LAMB3 18283320 430387 Regulation PIK3R1 MAP2K6 21762482 387051 Regulation PIK3R1 MAP2K6 24263101 569236 Regulation PIK3R1 MMP28 21799931 2539393 Regulation PIK3R1 MMP7 21799931 2539409 Regulation PIK3R1 OLFM4 25364714 861624 Regulation PIK3R1 PECAM1 20723025 1692136 Regulation PIK3R1 TLR7 22606294 2642953 Regulation PIK3R1 TLR7 24740015 2954271 Regulation PIK3R1 TM4SF19 25344917 2206291 Regulation PIK3R1 TM4SF19 25344917 2206292 Regulation PIK3R1 TNF 16504042 278996 Regulation PIK3R1 TNF 22973314 1069071 Regulation PIK3R1 TSPAN1 10491398 1249781 Regulation PIK3R2 RCAN1 19603121 1832710 Regulation PIKFYVE SLC6A2 21284875 258626 Regulation PIM1 CD14 21949737 2556422 Regulation PIM1 STAT4 23209281 1205779 Regulation PIM2 STAT4 23209281 1205780 Regulation PIM3 STAT4 23209281 1205778 Regulation PIN1 CAPN8 19545424 1625470 Regulation PIN1 DAPK1 23880846 1108938 Regulation PIN1 DAPK1 24853415 575975 Regulation PIN1 TLR7 21743479 1955578 Regulation PIP EPHB2 22817771 471863 Regulation PIP EPHB2 22817771 471864 Regulation PIP EPHB2 22817771 471865 Regulation PIP EPHB2 22817771 471871 Regulation PIP EPHB2 22817771 472013 Regulation PIP MIP 20817957 27650 Regulation PITX2 RGS2 22802950 2663741 Regulation PITX3 PGC 23145024 2715230 Regulation PKD1 FHL1 24219103 151971 Regulation PKD1 FHL1 24219103 151972 Regulation PKD1 FHL1 24219103 151973 Regulation PKD1 FHL1 24219103 151974 Regulation PKD1 FHL1 24219103 152013 Regulation PKD2 FHL1 24219103 151979 Regulation PKD2 FHL1 24219103 151980 Regulation PKD2 FHL1 24219103 151981 Regulation PKD2 FHL1 24219103 151982 Regulation PKD2 FHL1 24219103 152016 Regulation PKD2 MMP7 24336522 1820043 Regulation PKD2 MMP7 24336522 1820048 Regulation PKD3 FHL1 24219103 151987 Regulation PKD3 FHL1 24219103 151988 Regulation PKD3 FHL1 24219103 151989 Regulation PKD3 FHL1 24219103 151990 Regulation PKD3 FHL1 24219103 152019 Regulation PKM EGLN3 21709315 2176243 Regulation PKM EPHB2 23178880 1928813 Regulation PKN1 ARSA 23146664 154195 Regulation PKN1 TNF 19298660 352680 Regulation PLA2G12B PGC 21673902 1090928 Regulation PLA2G1B IL1B 18472822 1741851 Regulation PLA2G1B TNF 18475466 1743842 Regulation PLA2G1B TNF 25426024 872211 Regulation PLA2G4A EPHB2 19409102 1897183 Regulation PLA2G4A EPHB2 19409102 1897193 Regulation PLA2G4A EPHB2 21152208 22769 Regulation PLA2G4A EPHB2 22911431 3058942 Regulation PLA2G4A MAP2K6 12370087 225151 Regulation PLA2G4A MAP2K6 12370087 225159 Regulation PLA2G4A TNF 24069158 2851354 Regulation PLA2G4A TNF 24069158 2851529 Regulation PLA2G4A TNF 24349530 2898449 Regulation PLAGL1 GATM 23145134 2716184 Regulation PLAGL1 STC1 23145134 2716183 Regulation PLAT BDNF 17576803 1341635 Regulation PLAT BDNF 22034132 735040 Regulation PLAT CA2 25090090 2994829 Regulation PLAT CRH 18818748 2396847 Regulation PLAT DLG4 23866919 1895819 Regulation PLAT EGF 17261179 3096402 Regulation PLAT FGF2 8601593 1450645 Regulation PLAT HCLS1 17576803 1341609 Regulation PLAT HCLS1 17576803 1341621 Regulation PLAT HCLS1 17576803 1341641 Regulation PLAT HRAS 11437413 419205 Regulation PLAT HSPB3 18389070 631106 Regulation PLAT IL1A 24156000 1713098 Regulation PLAT IL6 21450059 1641002 Regulation PLAT KRAS 11437413 419206 Regulation PLAT LEP 17521427 370527 Regulation PLAT LRP1 23866919 1895802 Regulation PLAT MAPK1 24009867 204056 Regulation PLAT MAPK10 24009867 204057 Regulation PLAT MAPK11 24009867 204058 Regulation PLAT MAPK12 24009867 204059 Regulation PLAT MAPK13 24009867 204060 Regulation PLAT MAPK14 24009867 204061 Regulation PLAT MAPK15 24009867 204055 Regulation PLAT MAPK3 24009867 204062 Regulation PLAT MAPK4 24009867 204063 Regulation PLAT MAPK6 24009867 204064 Regulation PLAT MAPK7 24009867 204065 Regulation PLAT MAPK8 24009867 204066 Regulation PLAT MAPK9 24009867 204067 Regulation PLAT MYLIP 24911610 2978874 Regulation PLAT NGF 17576803 1341636 Regulation PLAT NRAS 11437413 419207 Regulation PLAT NTF3 17576803 1341622 Regulation PLAT NTF4 17576803 1341623 Regulation PLAT PAICS 19789215 811513 Regulation PLAT SDS 3121634 1425833 Regulation PLAT SERPINB2 24999729 2986620 Regulation PLAT SERPINE1 20300596 512946 Regulation PLAT SERPINE1 21785728 1155317 Regulation PLAT SERPINE1 22069469 2569032 Regulation PLAT SERPINE1 23118508 1225459 Regulation PLAT SERPINE1 24235858 1614609 Regulation PLAT SERPINE1 24235858 1614617 Regulation PLAT SERPINE1 24999729 2986619 Regulation PLAT SERPINI1 21569344 1697244 Regulation PLAT SERPINI1 24608243 2932703 Regulation PLAT SERPINI1 24608243 2932705 Regulation PLAT SHH 22432023 2611604 Regulation PLAT SIGLEC7 17576803 1341620 Regulation PLAT SRGN 21880179 623908 Regulation PLAT SRGN 24286332 222300 Regulation PLAT TNF 24156000 1713097 Regulation PLAT TNFRSF1B 17576803 1341600 Regulation PLAT TNFRSF1B 17576803 1341608 Regulation PLAT TNFRSF1B 17576803 1341629 Regulation PLAT TNFRSF1B 17576803 1341639 Regulation PLAT UCN2 23525432 1157522 Regulation PLAT UCN3 23525432 1157521 Regulation PLAT VEGFA 23308155 2738474 Regulation PLAT VEGFA 8601593 1450644 Regulation PLAU AHSA1 19497102 1503749 Regulation PLAU AKT1 23597113 128335 Regulation PLAU AKT1 23661031 735571 Regulation PLAU AKT2 23597113 128336 Regulation PLAU AKT2 23661031 735572 Regulation PLAU AKT3 23597113 128337 Regulation PLAU AKT3 23661031 735573 Regulation PLAU ANGPT1 20805979 2471620 Regulation PLAU AREG 23844004 2818955 Regulation PLAU BRMS1 24879377 2975657 Regulation PLAU BRMS1L 22076152 2570313 Regulation PLAU BSG 22443116 264371 Regulation PLAU BSG 22443116 264372 Regulation PLAU BSG 22443116 264373 Regulation PLAU BSG 22443116 264374 Regulation PLAU BSG 22443116 264375 Regulation PLAU BSG 22443116 264376 Regulation PLAU BSG 22443116 264378 Regulation PLAU BSG 22443116 264380 Regulation PLAU BSG 22443116 264384 Regulation PLAU BSG 24705283 2949064 Regulation PLAU CCNA1 18612129 1651551 Regulation PLAU CD44 22621373 471545 Regulation PLAU CD44 22621373 471546 Regulation PLAU CD44 23326564 2740723 Regulation PLAU CDC42 20067638 255089 Regulation PLAU CDC42 20067638 255090 Regulation PLAU CDC42 20067638 255139 Regulation PLAU CDC42 20067638 255156 Regulation PLAU CDC42 20067638 255167 Regulation PLAU CDC42 20067638 255185 Regulation PLAU CEBPA 18445634 2034380 Regulation PLAU CRK 19497102 1503764 Regulation PLAU CSF1 22909061 1866390 Regulation PLAU EGF 17261179 3096403 Regulation PLAU EGR1 21283769 2498246 Regulation PLAU EPHB2 19497102 1503751 Regulation PLAU EPHB2 19497102 1503752 Regulation PLAU EPHB2 19497102 1503765 Regulation PLAU EPHB2 19497102 1503775 Regulation PLAU EPHB2 19497102 1503781 Regulation PLAU EPHB2 21798065 1505394 Regulation PLAU EPHB2 23597113 128334 Regulation PLAU ETS1 22986534 2148779 Regulation PLAU ETS1 25079072 2993754 Regulation PLAU ETS2 15236655 3095828 Regulation PLAU FGF1 19808845 811538 Regulation PLAU FGF1 21799677 812935 Regulation PLAU FGF10 19808845 811539 Regulation PLAU FGF10 21799677 812936 Regulation PLAU FGF11 19808845 811540 Regulation PLAU FGF11 21799677 812937 Regulation PLAU FGF12 19808845 811541 Regulation PLAU FGF12 21799677 812938 Regulation PLAU FGF13 19808845 811542 Regulation PLAU FGF13 21799677 812939 Regulation PLAU FGF14 19808845 811543 Regulation PLAU FGF14 21799677 812940 Regulation PLAU FGF16 19808845 811544 Regulation PLAU FGF16 21799677 812941 Regulation PLAU FGF17 19808845 811545 Regulation PLAU FGF17 21799677 812942 Regulation PLAU FGF18 19808845 811546 Regulation PLAU FGF18 21799677 812943 Regulation PLAU FGF19 19808845 811547 Regulation PLAU FGF19 21799677 812944 Regulation PLAU FGF2 19808845 811548 Regulation PLAU FGF2 21151668 812308 Regulation PLAU FGF2 21799677 812945 Regulation PLAU FGF2 24944688 2168647 Regulation PLAU FGF20 19808845 811549 Regulation PLAU FGF20 21799677 812946 Regulation PLAU FGF21 19808845 811550 Regulation PLAU FGF21 21799677 812947 Regulation PLAU FGF22 19808845 811551 Regulation PLAU FGF22 21799677 812948 Regulation PLAU FGF23 19808845 811552 Regulation PLAU FGF23 21799677 812949 Regulation PLAU FGF3 19808845 811553 Regulation PLAU FGF3 21799677 812950 Regulation PLAU FGF4 19808845 811554 Regulation PLAU FGF4 21799677 812951 Regulation PLAU FGF5 19808845 811555 Regulation PLAU FGF5 21799677 812952 Regulation PLAU FGF6 19808845 811556 Regulation PLAU FGF6 21799677 812953 Regulation PLAU FGF7 19808845 811557 Regulation PLAU FGF7 21799677 812954 Regulation PLAU FGF8 19808845 811558 Regulation PLAU FGF8 21799677 812955 Regulation PLAU FGF9 19808845 811559 Regulation PLAU FGF9 21799677 812956 Regulation PLAU FOSL1 25200076 2104644 Regulation PLAU GATA4 23125522 1225551 Regulation PLAU GPI 22558080 2624256 Regulation PLAU GRAP2 22443116 264377 Regulation PLAU GRAP2 23597113 128338 Regulation PLAU GSN 22927998 2681287 Regulation PLAU GSN 22927998 2681299 Regulation PLAU GSN 22927998 2681301 Regulation PLAU HGF 16646560 1711378 Regulation PLAU HGF 19497102 1503766 Regulation PLAU HGF 19497102 1503776 Regulation PLAU HGF 24959301 1240510 Regulation PLAU HOXA5 23864708 1817030 Regulation PLAU HRAS 11437413 419208 Regulation PLAU HRAS 11437413 419221 Regulation PLAU HRAS 11437413 419224 Regulation PLAU IL1A 23502002 2086206 Regulation PLAU IL1A 23597113 128320 Regulation PLAU ILF3 22986534 2148770 Regulation PLAU ILF3 22986534 2148771 Regulation PLAU ILF3 22986534 2148772 Regulation PLAU ILF3 22986534 2148773 Regulation PLAU IRG1 21304816 2499931 Regulation PLAU ITGA4 24107265 1870060 Regulation PLAU JUN 22986534 2148786 Regulation PLAU JUN 23562655 829806 Regulation PLAU JUN 25200076 2104641 Regulation PLAU KAL1 24189182 787902 Regulation PLAU KAT2B 23502002 2086233 Regulation PLAU KRAS 11437413 419209 Regulation PLAU KRAS 11437413 419222 Regulation PLAU KRAS 11437413 419225 Regulation PLAU LPA 23326327 2739798 Regulation PLAU MAP3K1 16887003 460078 Regulation PLAU MAPK1 24466137 2913668 Regulation PLAU MAPK10 24466137 2913669 Regulation PLAU MAPK11 24466137 2913670 Regulation PLAU MAPK12 24466137 2913671 Regulation PLAU MAPK13 24466137 2913672 Regulation PLAU MAPK14 24466137 2913673 Regulation PLAU MAPK15 24466137 2913665 Regulation PLAU MAPK3 22952779 2684066 Regulation PLAU MAPK3 23468978 2760562 Regulation PLAU MAPK3 24466137 2913674 Regulation PLAU MAPK4 24466137 2913675 Regulation PLAU MAPK6 24466137 2913676 Regulation PLAU MAPK7 24466137 2913677 Regulation PLAU MAPK8 24466137 2913678 Regulation PLAU MAPK9 24466137 2913679 Regulation PLAU ME2 24314144 222364 Regulation PLAU MT-CO2 20931209 1072494 Regulation PLAU MYLIP 23459460 2342822 Regulation PLAU MYLIP 24330766 1870575 Regulation PLAU MYOCD 23125522 1225550 Regulation PLAU NA 19497102 1503753 Regulation PLAU NA 19497102 1503754 Regulation PLAU NA 19497102 1503767 Regulation PLAU NOTCH1 22004682 1863746 Regulation PLAU NOTCH1 22004682 1863823 Regulation PLAU NRAS 11437413 419210 Regulation PLAU NRAS 11437413 419223 Regulation PLAU NRAS 11437413 419226 Regulation PLAU PAF1 23502002 2086225 Regulation PLAU PAF1 23502002 2086229 Regulation PLAU PAICS 19789215 811514 Regulation PLAU PARP1 21595892 3207304 Regulation PLAU PARP10 21595892 3207299 Regulation PLAU PARP11 21595892 3207296 Regulation PLAU PARP12 21595892 3207297 Regulation PLAU PARP14 21595892 3207308 Regulation PLAU PARP15 21595892 3207302 Regulation PLAU PARP16 21595892 3207300 Regulation PLAU PARP2 21595892 3207306 Regulation PLAU PARP3 21595892 3207307 Regulation PLAU PARP4 21595892 3207305 Regulation PLAU PARP6 21595892 3207303 Regulation PLAU PARP8 21595892 3207301 Regulation PLAU PARP9 21595892 3207298 Regulation PLAU PDCD4 25144746 3001226 Regulation PLAU PI3 20459645 1854862 Regulation PLAU PIK3CA 17264880 2374621 Regulation PLAU PIK3CA 23661031 735574 Regulation PLAU PIK3R1 17264880 2374622 Regulation PLAU PIK3R1 23661031 735575 Regulation PLAU PLAUR 12668656 1291667 Regulation PLAU PLAUR 12952933 1296543 Regulation PLAU PLAUR 21535874 3207274 Regulation PLAU PLAUR 23125522 1225559 Regulation PLAU PLAUR 23125522 1225561 Regulation PLAU PLAUR 24129242 442100 Regulation PLAU PLG 10206287 414200 Regulation PLAU PLG 11056680 97969 Regulation PLAU PLG 11953871 421541 Regulation PLAU PLG 1661735 1328996 Regulation PLAU PLG 23849048 269388 Regulation PLAU PLG 24129242 442101 Regulation PLAU POLDIP2 19497102 1503774 Regulation PLAU PRB1 23485561 1812929 Regulation PLAU PRB1 23485561 1812941 Regulation PLAU PRB2 23485561 1812930 Regulation PLAU PRB2 23485561 1812942 Regulation PLAU PRB3 23485561 1812931 Regulation PLAU PRB3 23485561 1812943 Regulation PLAU PRB4 23485561 1812932 Regulation PLAU PRB4 23485561 1812944 Regulation PLAU PRDX6 17980029 461757 Regulation PLAU PRKAA1 23597113 128218 Regulation PLAU PRKAA1 23597113 128219 Regulation PLAU PRKAA2 23597113 128220 Regulation PLAU PRKAA2 23597113 128221 Regulation PLAU PRKAB1 23597113 128222 Regulation PLAU PRKAB1 23597113 128223 Regulation PLAU PRKAB2 23597113 128224 Regulation PLAU PRKAB2 23597113 128225 Regulation PLAU PRKAG1 23597113 128226 Regulation PLAU PRKAG1 23597113 128227 Regulation PLAU PRKAG2 23597113 128228 Regulation PLAU PRKAG2 23597113 128229 Regulation PLAU PTGER1 21813027 260792 Regulation PLAU PTGER3 21813027 260793 Regulation PLAU RAC1 20067638 255091 Regulation PLAU RAC1 20067638 255092 Regulation PLAU RAC1 20067638 255140 Regulation PLAU RAC1 20067638 255157 Regulation PLAU RAC1 20067638 255168 Regulation PLAU RAC1 20067638 255186 Regulation PLAU RNF19A 18629100 655563 Regulation PLAU RNF19A 19497102 1503750 Regulation PLAU RNF19A 22315682 1687186 Regulation PLAU SEMA5A 23661031 735546 Regulation PLAU SERPINB2 1661735 1328995 Regulation PLAU SERPINB2 24129242 442099 Regulation PLAU SERPINB2 24999729 2986622 Regulation PLAU SERPINB2 9472634 446870 Regulation PLAU SERPINE1 10817507 417103 Regulation PLAU SERPINE1 1661735 1328994 Regulation PLAU SERPINE1 18599586 83814 Regulation PLAU SERPINE1 23118508 1225460 Regulation PLAU SERPINE1 23451143 2758247 Regulation PLAU SERPINE1 23766912 3081249 Regulation PLAU SERPINE1 24129242 442098 Regulation PLAU SERPINE1 24340014 2894519 Regulation PLAU SERPINE1 24494029 1240283 Regulation PLAU SERPINE1 24999729 2986621 Regulation PLAU SERPINE1 9472634 446869 Regulation PLAU SETD2 24216979 500598 Regulation PLAU SLC17A5 22992293 292518 Regulation PLAU SMAD3 23984088 1150991 Regulation PLAU SMAD4 23984088 1151023 Regulation PLAU SRF 23125522 1225549 Regulation PLAU ST14 23675430 2792845 Regulation PLAU ST14 23675430 2792866 Regulation PLAU ST14 24146945 2869003 Regulation PLAU TCF12 23940799 2832505 Regulation PLAU TCF12 24466137 2913656 Regulation PLAU TCF15 23940799 2832506 Regulation PLAU TCF15 24466137 2913657 Regulation PLAU TCF19 23940799 2832507 Regulation PLAU TCF19 24466137 2913658 Regulation PLAU TCF20 23940799 2832508 Regulation PLAU TCF20 24466137 2913659 Regulation PLAU TCF21 23940799 2832509 Regulation PLAU TCF21 24466137 2913660 Regulation PLAU TCF23 23940799 2832513 Regulation PLAU TCF23 24466137 2913664 Regulation PLAU TCF24 23940799 2832515 Regulation PLAU TCF24 24466137 2913667 Regulation PLAU TCF25 23940799 2832514 Regulation PLAU TCF25 24466137 2913666 Regulation PLAU TCF3 23940799 2832510 Regulation PLAU TCF3 24466137 2913661 Regulation PLAU TCF4 23940799 2832511 Regulation PLAU TCF4 24466137 2913662 Regulation PLAU TCF7 23940799 2832512 Regulation PLAU TCF7 24466137 2913663 Regulation PLAU TCN1 24314144 222362 Regulation PLAU TCN2 24314144 222363 Regulation PLAU THBS1 10917542 417281 Regulation PLAU THBS1 10917542 417282 Regulation PLAU TIMP1 22558080 2624255 Regulation PLAU TNF 22927998 2681296 Regulation PLAU TNFRSF6B 24107265 1870059 Regulation PLAU TNFSF10 24481457 571852 Regulation PLAU TNFSF10 24481457 571854 Regulation PLAU TNFSF10 24481457 571870 Regulation PLAU VEGFA 20067638 255184 Regulation PLAU VTN 8830783 1456555 Regulation PLAUR EPHB2 12865932 422945 Regulation PLAUR EPHB2 21283769 2498251 Regulation PLAUR ITGB2 7535337 1590103 Regulation PLAUR PLAU 12952933 1296544 Regulation PLAUR PLAU 19893210 736372 Regulation PLAUR PLAU 23076139 518461 Regulation PLAUR PLAU 24348274 2354269 Regulation PLAUR RAB31 25472813 1486021 Regulation PLAUR TLR7 21998707 2562096 Regulation PLCB1 CAPN8 22563421 2626355 Regulation PLCB2 CAPN8 22563421 2626369 Regulation PLCB3 CAPN8 22563421 2626383 Regulation PLCB4 CAPN8 22563421 2626397 Regulation PLEK F2R 23239877 1205873 Regulation PLG MMP28 17848984 1054775 Regulation PLG MMP7 17848984 1054790 Regulation PLG PLAT 17134505 312965 Regulation PLG PLAT 17576803 1341630 Regulation PLG PLAT 17917109 1889776 Regulation PLG PLAT 22022509 2563331 Regulation PLG PLAT 23118506 1225376 Regulation PLG PLAT 23236466 2726471 Regulation PLG PLAT 24587197 2929041 Regulation PLG PLAU 10496343 415322 Regulation PLG PLAU 17134505 312979 Regulation PLG PLAU 17576803 1341631 Regulation PLG PLAU 19638192 374408 Regulation PLG PLAU 19672469 3074972 Regulation PLG PLAU 19893210 736373 Regulation PLG PLAU 21837240 1066616 Regulation PLG PLAU 22454771 154748 Regulation PLG PLAU 23125522 1225553 Regulation PLG PLAU 23125522 1225556 Regulation PLG PLAU 23236466 2726472 Regulation PLG PLAU 23236466 2726474 Regulation PLG PLAU 23675430 2792872 Regulation PLG PLAU 23710449 181729 Regulation PLG PLAU 23806081 3113683 Regulation PLG PLAU 23849048 269389 Regulation PLG PLAU 23853591 3062997 Regulation PLG PLAU 9472634 446864 Regulation PLK1 F2R 23926048 2212053 Regulation PLK1 FOXO1 19384426 668852 Regulation PLK1 TLR7 24205328 2876058 Regulation PLK1 TNF 20484576 1776879 Regulation PLK1 TNF 20484576 1776895 Regulation PLK1 TP63 23948487 2184640 Regulation PLP1 TUB 24081489 1411102 Regulation PLXNB1 EPHB2 15210733 1310172 Regulation PMPCB CCND1 23974100 544267 Regulation PMPCB TNF 22880094 2674203 Regulation PNPLA3 TNF 24915004 2979092 Regulation PODXL CDH5 25520612 939439 Regulation PODXL EBF1 24172684 1709573 Regulation PODXL LIMS1 21390327 2506431 Regulation PODXL SLC9A3R1 22932996 2235568 Regulation PODXL SP1 16684343 369995 Regulation PODXL SP1 16684343 369996 Regulation PODXL SP1 23560927 294334 Regulation PODXL WT1 24327929 2234767 Regulation POLD3 TLR7 19430534 2416267 Regulation POLDIP2 ID1 18489764 352171 Regulation POLDIP2 MAP2K6 21607062 950216 Regulation POLDIP2 MAP2K6 22219646 1913728 Regulation POLDIP2 MMP28 24928086 273928 Regulation POLDIP2 MMP7 24928086 273943 Regulation POLDIP2 PGC 22829833 1068747 Regulation POLDIP2 SPHK1 20498849 2451177 Regulation POLDIP2 TNF 21738708 2533444 Regulation POLR2A STK39 22303389 881897 Regulation POLR2B STK39 22303389 881912 Regulation POLR2C STK39 22303389 881927 Regulation POLR2D STK39 22303389 881942 Regulation POLR2E STK39 22303389 881957 Regulation POLR2F STK39 22303389 881972 Regulation POLR2G STK39 22303389 881987 Regulation POLR2H STK39 22303389 882002 Regulation POLR2I STK39 22303389 882017 Regulation POLR2J STK39 22303389 882032 Regulation POLR2K STK39 22303389 882047 Regulation POLR2L STK39 22303389 882062 Regulation POMC EPHB2 19066310 707402 Regulation POMC FOXO1 21642975 1966858 Regulation POT1 DAPK1 16476779 1327877 Regulation POT1 ITGB2 17692468 157362 Regulation POT1 TNF 24892036 1621661 Regulation POU2F1 EPHB2 24717932 1023946 Regulation POU5F1 EPHB2 24643025 2935537 Regulation POU5F1 NR2F1 23451132 2758132 Regulation POU5F1 ZFP57 24550733 2356319 Regulation POU5F1 ZFP57 24550733 2356509 Regulation POU5F1 ZFP57 24550733 2356510 Regulation POU5F1 ZFP57 24550733 2356685 Regulation PPA1 AXIN2 21814488 2276982 Regulation PPA2 AXIN2 21814488 2276976 Regulation PPARA CTGF 25132338 19422 Regulation PPARA IL1B 25152754 3077257 Regulation PPARA MAP2K6 18309369 3072145 Regulation PPARA PGC 23093952 3076040 Regulation PPARA PGC 23951275 2834103 Regulation PPARA PGC 25295003 860023 Regulation PPARA TNF 23251142 3076087 Regulation PPARD PGC 25295003 860024 Regulation PPARG EPHB2 20690415 1142896 Regulation PPARG MAP2K6 20690415 1142902 Regulation PPBP ATP5O 25288986 2254577 Regulation PPBP CTSG 24597571 1872469 Regulation PPBP IL6 23136963 412320 Regulation PPBP IL6 23136963 412321 Regulation PPBP IL6 23136963 412322 Regulation PPBP IL6 23136963 412324 Regulation PPL TNF 16177180 2017702 Regulation PPP1R12A AGR2 22641346 1397917 Regulation PPP2CA ARSA 19966835 8435 Regulation PPP2CA AXIN2 17961225 1646018 Regulation PPP2CA INPP4B 22895072 478807 Regulation PPP2CA TNF 23549267 1104970 Regulation PPP2R1A ARSA 19966835 8436 Regulation PPP2R1A AXIN2 17961225 1646021 Regulation PPP2R1A INPP4B 22895072 478808 Regulation PPP2R1A TNF 23549267 1104985 Regulation PPP2R2B ARSA 19966835 8437 Regulation PPP2R2B AXIN2 17961225 1646024 Regulation PPP2R2B INPP4B 22895072 478809 Regulation PPP2R2B TNF 23549267 1105000 Regulation PPP3CA FOXO1 20969782 330339 Regulation PPP3CA RCAN1 19124655 1553385 Regulation PPP3CA RCAN1 19725972 1646640 Regulation PPP3CA RCAN1 19725972 1646671 Regulation PPP3CA RCAN1 21629754 1052653 Regulation PPP3CA RCAN1 22461792 680261 Regulation PPP3CA RCAN1 23185487 2721143 Regulation PPP3CA RCAN1 25009690 2229552 Regulation PPP3CA RCAN1 25429622 579503 Regulation PPP3CA TNF 20507572 353449 Regulation PPP3CB FOXO1 20969782 330342 Regulation PPP3CB RCAN1 19725972 1646672 Regulation PPP3CB RCAN1 21629754 1052655 Regulation PPP3CB RCAN1 23185487 2721144 Regulation PPP3CB RCAN1 25009690 2229553 Regulation PPP3CC FOXO1 20969782 330345 Regulation PPP3CC RCAN1 19725972 1646673 Regulation PPP3CC RCAN1 21629754 1052657 Regulation PPP3CC RCAN1 23185487 2721145 Regulation PPP3CC RCAN1 25009690 2229554 Regulation PPP3R1 RCAN1 19124655 1553386 Regulation PPP3R1 RCAN1 19725972 1646641 Regulation PPP3R1 RCAN1 22461792 680262 Regulation PPP3R1 RCAN1 25429622 579504 Regulation PPP3R1 TNF 20507572 353450 Regulation PPRC1 PGC 22960139 1881381 Regulation PPT1 FOXO1 19936085 981471 Regulation PPT1 FOXO1 19936085 981483 Regulation PQBP1 EPHB2 22044770 387393 Regulation PRB1 EPHB2 21258428 1030574 Regulation PRB2 EPHB2 21258428 1030575 Regulation PRB3 EPHB2 21258428 1030576 Regulation PRB4 EPHB2 21258428 1030577 Regulation PRDM1 TNF 23977359 2840065 Regulation PRDM16 HES2 19050759 2401639 Regulation PRDX1 MMP7 24519465 2243690 Regulation PRDX2 DAPK1 20048748 8919 Regulation PRDX2 MMP7 24519465 2243691 Regulation PRDX3 MMP7 24519465 2243692 Regulation PRG2 TNF 18001488 109442 Regulation PRG2 TNF 19519926 113585 Regulation PRG3 TNF 18001488 109443 Regulation PRG3 TNF 19519926 113586 Regulation PRG4 TNF 18001488 109444 Regulation PRG4 TNF 19519926 113587 Regulation PRKAA1 EPHB2 24419232 506361 Regulation PRKAA1 FOXO1 21483870 2512519 Regulation PRKAA1 PGC 22829833 1068761 Regulation PRKAA1 PGC 24167585 2872273 Regulation PRKAA1 PGC 24822191 190572 Regulation PRKAA1 PGC 25192192 2245339 Regulation PRKAA1 PGC 25566462 1498501 Regulation PRKAA1 TNF 20808811 2472484 Regulation PRKAA1 TNF 21673972 2528146 Regulation PRKAA1 TNF 22550592 1079177 Regulation PRKAA1 TNF 24669186 742940 Regulation PRKAA2 EPHB2 24419232 506362 Regulation PRKAA2 FOXO1 21483870 2512521 Regulation PRKAA2 PGC 22829833 1068762 Regulation PRKAA2 PGC 24167585 2872274 Regulation PRKAA2 PGC 24822191 190573 Regulation PRKAA2 PGC 25192192 2245340 Regulation PRKAA2 PGC 25566462 1498502 Regulation PRKAA2 TNF 20808811 2472485 Regulation PRKAA2 TNF 21673972 2528147 Regulation PRKAA2 TNF 22550592 1079179 Regulation PRKAA2 TNF 24669186 742941 Regulation PRKAB1 EPHB2 24419232 506363 Regulation PRKAB1 FOXO1 21483870 2512523 Regulation PRKAB1 PGC 22829833 1068763 Regulation PRKAB1 PGC 24167585 2872275 Regulation PRKAB1 PGC 24822191 190574 Regulation PRKAB1 PGC 25192192 2245341 Regulation PRKAB1 PGC 25566462 1498503 Regulation PRKAB1 TNF 20808811 2472486 Regulation PRKAB1 TNF 21673972 2528148 Regulation PRKAB1 TNF 22550592 1079181 Regulation PRKAB1 TNF 24669186 742942 Regulation PRKAB2 EPHB2 24419232 506364 Regulation PRKAB2 FOXO1 21483870 2512525 Regulation PRKAB2 PGC 22829833 1068764 Regulation PRKAB2 PGC 24167585 2872276 Regulation PRKAB2 PGC 24822191 190575 Regulation PRKAB2 PGC 25192192 2245342 Regulation PRKAB2 PGC 25566462 1498504 Regulation PRKAB2 TNF 20808811 2472487 Regulation PRKAB2 TNF 21673972 2528149 Regulation PRKAB2 TNF 22550592 1079183 Regulation PRKAB2 TNF 24669186 742943 Regulation PRKACB EPHB2 23034049 3113206 Regulation PRKACB GLP1R 24244813 204887 Regulation PRKACB PGC 22500113 1224033 Regulation PRKACB TNF 23284918 2731287 Regulation PRKACG EPHB2 23034049 3113207 Regulation PRKACG GLP1R 24244813 204888 Regulation PRKACG PGC 22500113 1224034 Regulation PRKACG TNF 23284918 2731288 Regulation PRKAG1 EPHB2 24419232 506365 Regulation PRKAG1 FOXO1 21483870 2512527 Regulation PRKAG1 PGC 22829833 1068765 Regulation PRKAG1 PGC 24167585 2872277 Regulation PRKAG1 PGC 24822191 190576 Regulation PRKAG1 PGC 25192192 2245343 Regulation PRKAG1 PGC 25566462 1498505 Regulation PRKAG1 TNF 20808811 2472488 Regulation PRKAG1 TNF 21673972 2528150 Regulation PRKAG1 TNF 22550592 1079185 Regulation PRKAG1 TNF 24669186 742944 Regulation PRKAG2 EPHB2 24419232 506366 Regulation PRKAG2 FOXO1 21483870 2512529 Regulation PRKAG2 PGC 22829833 1068766 Regulation PRKAG2 PGC 24167585 2872278 Regulation PRKAG2 PGC 24822191 190577 Regulation PRKAG2 PGC 25192192 2245344 Regulation PRKAG2 PGC 25566462 1498506 Regulation PRKAG2 TNF 20808811 2472489 Regulation PRKAG2 TNF 21673972 2528151 Regulation PRKAG2 TNF 22550592 1079187 Regulation PRKAG2 TNF 24669186 742945 Regulation PRKAR1A EPHB2 23034049 3113208 Regulation PRKAR1A GLP1R 24244813 204889 Regulation PRKAR1A PGC 22500113 1224035 Regulation PRKAR1A TNF 23284918 2731289 Regulation PRKAR1B EPHB2 23034049 3113209 Regulation PRKAR1B GLP1R 24244813 204890 Regulation PRKAR1B PGC 22500113 1224036 Regulation PRKAR1B TNF 23284918 2731290 Regulation PRKAR2A EPHB2 23034049 3113210 Regulation PRKAR2A GLP1R 24244813 204891 Regulation PRKAR2A PGC 22500113 1224037 Regulation PRKAR2A TNF 23284918 2731291 Regulation PRKAR2B EPHB2 23034049 3113211 Regulation PRKAR2B GLP1R 24244813 204892 Regulation PRKAR2B PGC 22500113 1224038 Regulation PRKAR2B TNF 23284918 2731292 Regulation PRL EPHB2 20885978 2475799 Regulation PRL EPHB2 22152284 1641014 Regulation PRL FOXO1 23349855 2743548 Regulation PRL TNF 22894827 126640 Regulation PRL TNF 23626671 2783584 Regulation PRLR TNF 23626671 2783585 Regulation PRNP MAP2K6 25364742 862412 Regulation PRODH CHDH 24039956 2845123 Regulation PRODH CKAP4 23861960 2821066 Regulation PRODH MYC 22737668 940859 Regulation PRODH MYC 22737668 940863 Regulation PRODH MYLIP 22737668 940852 Regulation PRODH PI3 25628629 972048 Regulation PRODH TP53 23861960 2821064 Regulation PRODH TP53 23861960 2821065 Regulation PRODH TP53 23861960 2821073 Regulation PROK1 TNFSF10 23531545 2086342 Regulation PROM1 GPR87 23593389 2780809 Regulation PROS1 EPHB2 25029544 1128410 Regulation PRR11 TNF 16277694 104772 Regulation PRR12 TNF 16277694 104778 Regulation PRR13 TNF 16277694 104771 Regulation PRR14 TNF 16277694 104776 Regulation PRR15 TNF 16277694 104770 Regulation PRR16 TNF 16277694 104779 Regulation PRR18 TNF 16277694 104777 Regulation PRR19 TNF 16277694 104783 Regulation PRR21 TNF 16277694 104784 Regulation PRR22 TNF 16277694 104775 Regulation PRR24 TNF 16277694 104773 Regulation PRR25 TNF 16277694 104785 Regulation PRR26 TNF 16277694 104780 Regulation PRR3 TNF 16277694 104769 Regulation PRR4 TNF 16277694 104768 Regulation PRR5 TNF 16277694 104781 Regulation PRR7 TNF 16277694 104774 Regulation PRR9 TNF 16277694 104782 Regulation PRS EDN2 23469133 2762020 Regulation PRSS21 CPP 19949457 860341 Regulation PRSS21 SORBS1 19014578 3096781 Regulation PRTN3 EPHB2 22675451 2648391 Regulation PSEN2 ARSA 14633288 392518 Regulation PSG1 SRGN 22754550 925142 Regulation PSG11 SRGN 22754550 925143 Regulation PSG2 SRGN 22754550 925144 Regulation PSG3 SRGN 22754550 925145 Regulation PSG4 SRGN 22754550 925146 Regulation PSG5 SRGN 22754550 925147 Regulation PSG6 SRGN 22754550 925148 Regulation PSG7 SRGN 22754550 925149 Regulation PSG8 SRGN 22754550 925150 Regulation PSG9 SRGN 22754550 925151 Regulation PSMA1 OSR1 21343295 1190840 Regulation PSMA2 OSR1 21343295 1190842 Regulation PSMA5 OSR1 21343295 1190844 Regulation PSMA7 OSR1 21343295 1190846 Regulation PSMB1 OSR1 21343295 1190848 Regulation PSMB10 OSR1 21343295 1190850 Regulation PSMB2 OSR1 21343295 1190852 Regulation PSMB3 OSR1 21343295 1190854 Regulation PSMB6 OSR1 21343295 1190856 Regulation PSMB7 OSR1 21343295 1190858 Regulation PSMB8 OSR1 21343295 1190860 Regulation PSMB9 OSR1 21343295 1190862 Regulation PSMC1 OSR1 21343295 1190864 Regulation PSMC2 OSR1 21343295 1190866 Regulation PSMC3 OSR1 21343295 1190868 Regulation PSMC3 STK39 21991300 2561298 Regulation PSMC4 OSR1 21343295 1190870 Regulation PSMC5 OSR1 21343295 1190872 Regulation PSMC6 OSR1 21343295 1190874 Regulation PSMD1 OSR1 21343295 1190876 Regulation PSMD10 OSR1 21343295 1190878 Regulation PSMD12 OSR1 21343295 1190880 Regulation PSMD13 OSR1 21343295 1190882 Regulation PSMD2 OSR1 21343295 1190884 Regulation PSMD4 OSR1 21343295 1190886 Regulation PSMD5 OSR1 21343295 1190888 Regulation PSMD6 OSR1 21343295 1190890 Regulation PSMD7 OSR1 21343295 1190892 Regulation PSMD8 OSR1 21343295 1190894 Regulation PSMD9 OSR1 21343295 1190896 Regulation PSME1 OSR1 21343295 1190898 Regulation PSME2 OSR1 21343295 1190900 Regulation PSME3 OSR1 21343295 1190902 Regulation PSMF1 OSR1 21343295 1190904 Regulation PTBP1 ARSA 18411340 1550474 Regulation PTBP1 CCL17 24701375 2163134 Regulation PTBP1 EDN2 18195069 1548362 Regulation PTBP1 EDN2 18195069 1548447 Regulation PTBP1 EPHB2 25111504 2996293 Regulation PTBP1 ITGAL 21980488 2560950 Regulation PTBP1 ITGB2 22238634 2586768 Regulation PTBP1 ITGB2 22238634 2586769 Regulation PTBP1 MAP2K6 21544193 2517149 Regulation PTBP1 NT5E 23520507 2768965 Regulation PTBP1 STAT4 20231889 2443110 Regulation PTBP1 TLR7 12045249 1523548 Regulation PTBP1 TLR7 18086320 109713 Regulation PTBP1 TLR7 19476613 113394 Regulation PTBP1 TLR7 19476613 113402 Regulation PTBP1 TLR7 19557165 3044301 Regulation PTBP1 TLR7 20617179 3047933 Regulation PTBP1 TLR7 22125457 3152226 Regulation PTBP1 TLR7 22190970 633727 Regulation PTBP1 TLR7 22474436 980141 Regulation PTBP1 TLR7 22905233 2675795 Regulation PTBP1 TLR7 22984435 2688641 Regulation PTBP1 TLR7 24204367 909833 Regulation PTBP1 TLR7 24335833 1736655 Regulation PTBP1 TLR7 24705920 2949332 Regulation PTBP1 TLR7 25093822 2995311 Regulation PTBP1 TLR7 25153703 3002332 Regulation PTBP1 TLR7 25153703 3002389 Regulation PTBP1 TLR7 25429207 3216598 Regulation PTBP1 TNF 12823847 99844 Regulation PTBP1 TNF 19715582 353121 Regulation PTBP1 TNF 25123797 368561 Regulation PTBP2 ARSA 18411340 1550471 Regulation PTBP2 CCL17 24701375 2163128 Regulation PTBP2 EDN2 18195069 1548350 Regulation PTBP2 EDN2 18195069 1548438 Regulation PTBP2 EPHB2 25111504 2996286 Regulation PTBP2 ITGAL 21980488 2560946 Regulation PTBP2 ITGB2 22238634 2586762 Regulation PTBP2 ITGB2 22238634 2586763 Regulation PTBP2 MAP2K6 21544193 2517143 Regulation PTBP2 NT5E 23520507 2768962 Regulation PTBP2 STAT4 20231889 2443094 Regulation PTBP2 TLR7 12045249 1523545 Regulation PTBP2 TLR7 18086320 109683 Regulation PTBP2 TLR7 19476613 113391 Regulation PTBP2 TLR7 19476613 113399 Regulation PTBP2 TLR7 19557165 3044271 Regulation PTBP2 TLR7 20617179 3047903 Regulation PTBP2 TLR7 22125457 3152196 Regulation PTBP2 TLR7 22190970 633697 Regulation PTBP2 TLR7 22474436 980111 Regulation PTBP2 TLR7 22905233 2675765 Regulation PTBP2 TLR7 22984435 2688601 Regulation PTBP2 TLR7 24204367 909793 Regulation PTBP2 TLR7 24335833 1736622 Regulation PTBP2 TLR7 24705920 2949292 Regulation PTBP2 TLR7 25093822 2995305 Regulation PTBP2 TLR7 25153703 3002302 Regulation PTBP2 TLR7 25153703 3002359 Regulation PTBP2 TLR7 25429207 3216548 Regulation PTBP2 TNF 12823847 99841 Regulation PTBP2 TNF 19715582 353115 Regulation PTBP2 TNF 25123797 368554 Regulation PTEN EPHB2 19881543 2127993 Regulation PTEN ID1 21293053 2174745 Regulation PTEN TM4SF19 25344917 2206300 Regulation PTGDS IL1B 19094210 112287 Regulation PTGER2 ADCY1 22012553 494166 Regulation PTGER2 ADCY10 22012553 494165 Regulation PTGER2 ADCY2 22012553 494167 Regulation PTGER2 ADCY3 22012553 494168 Regulation PTGER2 ADCY4 22012553 494169 Regulation PTGER2 ADCY5 22012553 494170 Regulation PTGER2 ADCY6 22012553 494171 Regulation PTGER2 ADCY7 22012553 494172 Regulation PTGER2 ADCY8 22012553 494173 Regulation PTGER2 ADCY9 22012553 494174 Regulation PTGER2 CXCR4 20705717 1885424 Regulation PTGER2 MICE 22654101 1203468 Regulation PTGER2 PGR 20948178 3079135 Regulation PTGER2 PRKACB 25327961 216597 Regulation PTGER2 PRKACG 25327961 216598 Regulation PTGER2 PRKAR1A 25327961 216599 Regulation PTGER2 PRKAR1B 25327961 216600 Regulation PTGER2 PRKAR2A 25327961 216601 Regulation PTGER2 PRKAR2B 25327961 216602 Regulation PTGER4 EPHB2 22159280 83845 Regulation PTGER4 SLCO2A1 25505603 2248715 Regulation PTGES PTGER2 25327961 216605 Regulation PTGES TNF 15899061 103841 Regulation PTGES TNF PMC2834086 134570 Regulation PTGES3 ETV7 22291956 2591375 Regulation PTGES3 ZFP57 25032857 577529 Regulation PTGIS CSRP1 19480687 360034 Regulation PTGS1 TLR7 23850620 145307 Regulation PTGS2 ALOX5 24064666 1920006 Regulation PTGS2 CAPN8 19545424 1625371 Regulation PTGS2 CAPN8 19545424 1625372 Regulation PTGS2 EPHB2 10725339 1256857 Regulation PTGS2 EPHB2 18404483 3088088 Regulation PTGS2 EPHB2 19327173 113095 Regulation PTGS2 EPHB2 22675459 2648707 Regulation PTGS2 EPHB2 22927840 23045 Regulation PTGS2 EPHB2 24385109 1880242 Regulation PTGS2 IFI27 22397681 1698179 Regulation PTGS2 IL1B 11200365 1737638 Regulation PTGS2 IL1B 23844276 2226533 Regulation PTGS2 PGC 20661474 2456769 Regulation PTGS2 PTGER2 25327961 216606 Regulation PTGS2 SPHK1 24385109 1880261 Regulation PTGS2 TGM2 24009824 203571 Regulation PTGS2 TGM2 24009824 203572 Regulation PTGS2 TGM2 24009824 203574 Regulation PTGS2 TGM2 24009824 203575 Regulation PTGS2 TLR7 22027478 1023485 Regulation PTGS2 TNF 11132773 1737269 Regulation PTGS2 TNF 11238591 1518883 Regulation PTGS2 TNF 11238591 1518884 Regulation PTGS2 TNF 20953381 1748556 Regulation PTGS2 TNF 22605974 1095608 Regulation PTGS2 TNF 23024463 1750600 Regulation PTGS2 TNF 23024463 1750606 Regulation PTGS2 TNF 23056034 3075987 Regulation PTGS2 TNF 23346188 817064 Regulation PTGS2 TNF 23688423 314109 Regulation PTGS2 TNF 23688423 314176 Regulation PTGS2 TNF 23700398 1039691 Regulation PTGS2 TNF 24156000 1713093 Regulation PTGS2 TNF 24349530 2898420 Regulation PTGS2 TNF 9927229 1764295 Regulation PTHLH EPHB2 25003010 3092925 Regulation PTHLH TNF 20953899 645854 Regulation PTK6 EPHB2 24788754 2959292 Regulation PTK6 FOXO1 21479203 2511168 Regulation PTN FOXO1 23469153 2762500 Regulation PTPN1 CAPN8 18332219 1350020 Regulation PTPN1 TNF 24590766 1575155 Regulation PTPN11 GAB3 21118992 1783668 Regulation PTPN11 PECAM1 20723025 1692117 Regulation PTPN13 FAS 24316673 1930415 Regulation PTPN22 CD22 25101192 3151878 Regulation PTPN6 CD22 8627166 1596135 Regulation PTPN7 EPHB2 23761790 907705 Regulation PTPRJ GPR115 24016860 129677 Regulation PTPRJ GPR132 24016860 129666 Regulation PTPRJ GPR87 24016860 129746 Regulation PTTG1 FOXO1 22645648 2208390 Regulation PTX3 EPHB2 24457902 2186918 Regulation PTX3 TLR7 24060373 1700545 Regulation PTX3 TNF 19014569 313017 Regulation PTX3 TNF 20003354 117899 Regulation PTX3 TNF 21637713 2525838 Regulation PTX3 TNF 22529962 2620735 Regulation PTX3 TNF 23401658 1915598 Regulation PTX3 TNF 23531541 1103889 Regulation PTX3 TNF 25393877 3026869 Regulation PTX4 TNF 20003354 117897 Regulation PTX4 TNF 23531541 1103886 Regulation PTX4 TNF 25393877 3026868 Regulation PUM1 EPHB2 25349449 2250844 Regulation PUM1 FAS 24901238 3068119 Regulation PUM1 MAP2K6 25349449 2250850 Regulation PVR TLR7 23349877 2743812 Regulation PVR TLR7 23349877 2743915 Regulation PVR TLR7 23349877 2743933 Regulation PXN EPHB2 20011539 2433642 Regulation PXN EPHB2 22859931 2670474 Regulation PXN FAS 18056416 1346763 Regulation PXN TNF 7525608 1436365 Regulation PXN TNF 7525608 1436370 Regulation PXN TNF 7525608 1436371 Regulation PYY FAS 22844422 2668145 Regulation QRICH1 GPR115 24339877 2893510 Regulation QRICH1 GPR132 24339877 2893499 Regulation QRICH1 GPR87 24339877 2893579 Regulation QRICH2 GPR115 24339877 2893610 Regulation QRICH2 GPR132 24339877 2893599 Regulation QRICH2 GPR87 24339877 2893679 Regulation RAB10 TLR7 25118589 1944390 Regulation RAB12 TLR7 25118589 1944379 Regulation RAB13 TLR7 25118589 1944400 Regulation RAB14 TLR7 25118589 1944261 Regulation RAB15 TLR7 25118589 1944339 Regulation RAB17 TLR7 25118589 1944251 Regulation RAB18 TLR7 25118589 1944179 Regulation RAB19 TLR7 25118589 1944319 Regulation RAB20 TLR7 25118589 1944289 Regulation RAB21 TLR7 25118589 1944299 Regulation RAB22A RINL 21419809 158721 Regulation RAB23 TLR7 25118589 1944199 Regulation RAB24 MMP28 23613970 2782960 Regulation RAB24 TLR7 25118589 1944410 Regulation RAB25 TLR7 25118589 1944279 Regulation RAB26 TLR7 25118589 1944189 Regulation RAB28 TLR7 25118589 1944420 Regulation RAB30 TLR7 25118589 1944430 Regulation RAB31 ARHGAP4 11927603 1280641 Regulation RAB31 CHM 20027300 2435089 Regulation RAB31 CHM 23667438 2790560 Regulation RAB31 ESR1 25261375 2202253 Regulation RAB31 GABARAPL2 20562859 1985392 Regulation RAB31 GDI1 21931684 2554149 Regulation RAB31 GDI1 23154999 1809541 Regulation RAB31 GDI2 21931684 2554150 Regulation RAB31 GDI2 23154999 1809542 Regulation RAB31 GOLGA2 11927603 1280639 Regulation RAB31 GOLGB1 11927603 1280640 Regulation RAB31 HIST1H3H 20375147 1775663 Regulation RAB31 HOXD13 21850271 2542788 Regulation RAB31 IGKV6D-21 21850271 2542789 Regulation RAB31 MADD 18559336 1163965 Regulation RAB31 MUC1 22792175 2661055 Regulation RAB31 MUC1 22792175 2661077 Regulation RAB31 MUC1 25261375 2202230 Regulation RAB31 MUC1 25261375 2202254 Regulation RAB31 RAB1A 22529993 2620830 Regulation RAB31 RAB3GAP1 18463892 810164 Regulation RAB31 RAB3GAP1 24312013 868083 Regulation RAB31 RBBP8 9679147 1468703 Regulation RAB31 SLC6A11 24225037 388914 Regulation RAB31 TLR1 25118589 1944435 Regulation RAB31 TLR10 25118589 1944443 Regulation RAB31 TLR2 25118589 1944436 Regulation RAB31 TLR3 25118589 1944437 Regulation RAB31 TLR4 25118589 1944438 Regulation RAB31 TLR5 25118589 1944439 Regulation RAB31 TLR6 25118589 1944444 Regulation RAB31 TLR7 25118589 1944440 Regulation RAB31 TLR8 25118589 1944441 Regulation RAB31 TLR9 25118589 1944442 Regulation RAB31 TRNAC1 24885147 246378 Regulation RAB31 TRNAE1 24349132 2896834 Regulation RAB32 TLR7 25118589 1944450 Regulation RAB34 TLR7 25118589 1944241 Regulation RAB35 TLR7 25118589 1944460 Regulation RAB36 TLR7 25118589 1944470 Regulation RAB37 TLR7 25118589 1944369 Regulation RAB38 TLR7 25118589 1944480 Regulation RAB41 TLR7 25118589 1944309 Regulation RAB42 TLR7 25118589 1944359 Regulation RAB43 TLR7 25118589 1944329 Regulation RAB44 TLR7 25118589 1944349 Regulation RAB5A RINL 21419809 158722 Regulation RABEPK EPHB2 22852877 532946 Regulation RABEPK TLR7 23071254 1569701 Regulation RABEPK TP63 18847496 111635 Regulation RAC1 ANGPT1 21858121 2546400 Regulation RAC1 CAPN8 11062268 1264730 Regulation RAC1 CAPN8 11062268 1264912 Regulation RAC1 CAPN8 11062268 1265041 Regulation RAC1 EPHB2 11980921 1282374 Regulation RAC1 EPHB2 19182796 1965181 Regulation RAC1 EPHB2 22970259 2687867 Regulation RAC1 EPHB2 23389627 1811837 Regulation RAC1 EPHB2 23389627 1811904 Regulation RAC1 EPHB2 25123138 1129025 Regulation RAC1 EPHB2 25123138 1129030 Regulation RAC1 EPHB2 25123138 1129040 Regulation RAC1 FZD4 22325146 1864910 Regulation RAC1 GAB3 21118992 1783682 Regulation RAC1 GAB3 21118992 1783692 Regulation RAC1 PECAM1 23733346 1405457 Regulation RAC1 PLAU 12952933 1296545 Regulation RAC1 PLAU 12952933 1296556 Regulation RAC1 RGS2 23760466 1732363 Regulation RAC1 TLR7 25118589 1944490 Regulation RAC2 CAPN8 11062268 1264744 Regulation RAC2 CAPN8 11062268 1264926 Regulation RAC2 CAPN8 11062268 1265055 Regulation RAC2 EPHB2 11980921 1282375 Regulation RAC2 EPHB2 23389627 1811839 Regulation RAC2 EPHB2 23389627 1811906 Regulation RAC2 FZD4 22325146 1864920 Regulation RAC2 PLAU 12952933 1296546 Regulation RAC2 PLAU 12952933 1296557 Regulation RAC2 RGS2 23760466 1732367 Regulation RAC2 TLR7 25118589 1944500 Regulation RAC3 CAPN8 11062268 1264758 Regulation RAC3 CAPN8 11062268 1264940 Regulation RAC3 CAPN8 11062268 1265069 Regulation RAC3 EPHB2 11980921 1282376 Regulation RAC3 EPHB2 23389627 1811841 Regulation RAC3 EPHB2 23389627 1811908 Regulation RAC3 FZD4 22325146 1864930 Regulation RAC3 PLAU 12952933 1296547 Regulation RAC3 PLAU 12952933 1296558 Regulation RAC3 RGS2 23760466 1732371 Regulation RAC3 TLR7 25118589 1944510 Regulation RAD50 DAPK1 16476779 1327886 Regulation RAD50 ITGB2 17692468 157365 Regulation RAD50 PECAM1 10725328 1256593 Regulation RAD50 TLR7 25118589 1945152 Regulation RAD51 PPBP 23637786 2786039 Regulation RAD51 TNF 25310191 3015023 Regulation RAE1 TLR7 23316194 905668 Regulation RAET1E MYC 23166357 1569886 Regulation RAF1 EPHB2 18335053 2387072 Regulation RAF1 MAP2K6 22826029 723949 Regulation RAF1 MAP2K6 22984397 2688283 Regulation RAG1 EPHB2 14624253 2255185 Regulation RAG1 FOXO1 18978794 1951894 Regulation RAG1 FOXO1 18978794 1951915 Regulation RAG1 FOXO1 18978794 1951919 Regulation RAG1 FOXO1 21655267 2527794 Regulation RAG1 FOXO1 21655267 2527809 Regulation RAG1 FOXO1 21655267 2527821 Regulation RAG1 FOXO1 22291095 1567011 Regulation RAG1 FOXO1 22997486 656251 Regulation RAG1 FOXO1 23878308 1572796 Regulation RAG1 FOXO1 23878308 1572838 Regulation RAG1 FOXO1 25400915 1037027 Regulation RAG1 FOXO1 25400915 1037165 Regulation RAG2 FOXO1 18978794 1951916 Regulation RAG2 FOXO1 18978794 1951920 Regulation RAG2 FOXO1 21655267 2527796 Regulation RAG2 FOXO1 21655267 2527811 Regulation RAG2 FOXO1 21655267 2527823 Regulation RAG2 FOXO1 22291095 1567012 Regulation RAG2 FOXO1 22997486 656252 Regulation RAG2 FOXO1 23878308 1572799 Regulation RAG2 FOXO1 23878308 1572840 Regulation RAG2 FOXO1 25400915 1037034 Regulation RANBP2 INPP4B 25126743 2998016 Regulation RANBP3 EPHB2 24247654 1721911 Regulation RARB IAPP 2438371 1611114 Regulation RARB NCL 22693611 2650950 Regulation RARB NCL 22693611 2650956 Regulation RARB NCL 22693611 2650957 Regulation RARB NCL 22693611 2650963 Regulation RARB NR2F2 22693611 2650958 Regulation RARB NR2F2 22693611 2650964 Regulation RARB RARA 9255592 797247 Regulation RARB RXRA 9255592 797246 Regulation RARS PGC 24059847 290138 Regulation RASA1 EPHB2 21200439 2489531 Regulation RASA1 RAB31 23878272 1406238 Regulation RASD1 AMPH 24817889 1070774 Regulation RASD1 INS 24817889 1070772 Regulation RASD1 MYLIP 23202960 1098887 Regulation RASD1 NOS1 21245950 1912600 Regulation RASGRF1 CAPN8 19678938 116548 Regulation RASGRF1 CAPN8 19678938 116549 Regulation RASSF10 PRKACB 23552700 2156434 Regulation RASSF10 PRKACG 23552700 2156435 Regulation RASSF10 PRKAR1A 23552700 2156436 Regulation RASSF10 PRKAR1B 23552700 2156437 Regulation RASSF10 PRKAR2A 23552700 2156438 Regulation RASSF10 PRKAR2B 23552700 2156439 Regulation RB1 CCND1 24876129 758429 Regulation RB1 EPHB2 24330646 412498 Regulation RB1 MAP2K6 22531632 438643 Regulation RB1 PECAM1 24548763 809527 Regulation RB1 PIGR 24699841 1886378 Regulation RBCK1 TNF 23104095 1958297 Regulation RBFOX3 TLR7 24740015 2953866 Regulation RBFOX3 TLR7 24740015 2954383 Regulation RBL1 EPHB2 23829771 410465 Regulation RBL1 PGC 20713602 1378398 Regulation RBL1 PGC 20713602 1378405 Regulation RBP4 TNF 19597296 736298 Regulation RBP4 TNF 19597296 736302 Regulation RBPJ TNF 22249448 1566910 Regulation RCAN1 ARHGAP22 19603121 1832619 Regulation RCAN1 CA2 19725972 1646661 Regulation RCAN1 EGFR 19603121 1832620 Regulation RCAN1 HDAC3 25144594 3001076 Regulation RCAN1 HDAC3 25144594 3001077 Regulation RCAN1 HDAC3 25144594 3001104 Regulation RCAN1 IL12RB1 18755030 324108 Regulation RCAN1 NFATC1 19348862 158366 Regulation RCAN1 NFATC1 19860902 526178 Regulation RCAN1 NFATC1 21464221 1563203 Regulation RCAN1 PGF 19819266 158565 Regulation RCAN1 PGF 19819266 158579 Regulation RCAN1 PIK3R2 19603121 1832621 Regulation RCAN1 PPP3CA 19725972 1646665 Regulation RCAN1 PPP3CA 19725972 1646676 Regulation RCAN1 PPP3CA 19725972 1646682 Regulation RCAN1 PPP3CA 22461792 680257 Regulation RCAN1 PPP3CA 22461792 680258 Regulation RCAN1 PPP3CA 25009690 2229549 Regulation RCAN1 PPP3CB 19725972 1646666 Regulation RCAN1 PPP3CB 19725972 1646683 Regulation RCAN1 PPP3CB 25009690 2229550 Regulation RCAN1 PPP3CC 19725972 1646667 Regulation RCAN1 PPP3CC 19725972 1646684 Regulation RCAN1 PPP3CC 25009690 2229551 Regulation RCAN1 PPP3R1 19725972 1646677 Regulation RCAN1 PPP3R1 22461792 680259 Regulation RCAN1 PPP3R1 22461792 680260 Regulation RCAN1 VEGFA 20625401 2454994 Regulation REG1A TLR7 17283209 1544295 Regulation REG3A EPHB2 18084034 2032234 Regulation REG3A EPHB2 18084034 2032250 Regulation REL RCAN1 19603121 1832713 Regulation REL TNF 21915344 2553427 Regulation REL TNF 24024170 3093439 Regulation RELA CCND1 23145063 2715550 Regulation RELA EPHB2 23762330 2803049 Regulation RELA IL1B 23323936 239526 Regulation RELA MAP2K6 23675062 1064480 Regulation RELA MMP28 25099178 2995568 Regulation RELA MMP7 25099178 2995583 Regulation RELA TLR7 24454965 2910544 Regulation RELA TM4SF19 25344917 2206306 Regulation RELA TNF 11097206 702064 Regulation RELA TNF 17032459 319208 Regulation RELA TNF 17868448 392118 Regulation RELA TNF 19036161 1238127 Regulation RELA TNF 20948609 846234 Regulation RELA TNF 21131967 1954743 Regulation RELA TNF 21131967 1954749 Regulation RELA TNF 21539730 1626350 Regulation RELA TNF 21593200 719219 Regulation RELA TNF 21765477 2141241 Regulation RELA TNF 2193094 1565443 Regulation RELA TNF 22654792 875822 Regulation RELA TNF 22654792 875823 Regulation RELA TNF 22787387 742507 Regulation RELA TNF 22870920 239403 Regulation RELA TNF 22911724 2675985 Regulation RELA TNF 22911724 2675994 Regulation RELA TNF 22996371 1029310 Regulation RELA TNF 23271966 3060158 Regulation RELA TNF 23576877 1628500 Regulation RELA TNF 23576877 1628504 Regulation RELA TNF 23593011 2345225 Regulation RELA TNF 24004852 803468 Regulation RELA TNF 24710489 618878 Regulation RELA TNF 25074812 1488224 Regulation RELA TNF 25076912 965647 Regulation RELA TNF 7561697 1590674 Regulation RELA TNF 8655581 1451892 Regulation RELA TNF 8698809 1452488 Regulation RELA TNF PMC2750202 450205 Regulation RELB TNF 22880094 2674205 Regulation RELN PLAT 23082219 2705564 Regulation RELN PLAT 23082219 2705565 Regulation REN RASD1 21247419 376239 Regulation REN RASD1 21247419 376240 Regulation REN RASD1 21247419 376256 Regulation REN RASD1 21247419 376279 Regulation REN RASD1 21247419 376302 Regulation REN RASD1 21247419 376305 Regulation RET EPHB2 20386724 2271428 Regulation RET FOXO1 22529334 30615 Regulation RET IFI27 23509459 1073488 Regulation RETN EPHB2 21655142 1075772 Regulation RETN TNF 18335040 2386920 Regulation RETN TNF 19473519 1227129 Regulation RETN TNF 19473519 1227130 Regulation RETN TNF 19473519 1227147 Regulation RETN TNF 19473519 1227150 Regulation RGMA UNC5B 19273616 1364461 Regulation RGS16 DUSP6 16012519 426299 Regulation RGS16 MYLIP 22817753 155865 Regulation RGS16 RB1 25568667 987490 Regulation RGS16 RB1 25568667 987491 Regulation RGS16 TP53 25568667 987489 Regulation RGS2 CAV1 17986358 321018 Regulation RGS2 NOS3 17986358 321019 Regulation RGS2 NPAS4 23656887 727282 Regulation RGS2 NPAS4 23656887 727305 Regulation RGS2 NPPA 20352235 142252 Regulation RGS2 TAC1 22802950 2663756 Regulation RGS2 TAC1 22802950 2663760 Regulation RGS2 TAC1 22802950 2663766 Regulation RGS2 TAC3 22802950 2663757 Regulation RGS2 TAC3 22802950 2663761 Regulation RGS2 TAC3 22802950 2663767 Regulation RGS2 TAC4 22802950 2663758 Regulation RGS2 TAC4 22802950 2663762 Regulation RGS2 TAC4 22802950 2663768 Regulation RGS2 UCHL5 21048919 2479739 Regulation RHEB EPHB2 24391850 2904757 Regulation RHO EPHB2 18614536 1164097 Regulation RHO EPHB2 23986484 1487108 Regulation RHO RGS2 23760466 1732359 Regulation RHO TMOD1 24130935 204624 Regulation RHO TNF 23544124 2773534 Regulation RHOA ANGPT1 21858121 2546399 Regulation RHOA CCND1 22070920 1863892 Regulation RHOA EPHB2 15210733 1310170 Regulation RHOA EPHB2 22593214 1803217 Regulation RHOA IFI27 10427091 1248778 Regulation RHOA IFI27 21423803 2508394 Regulation RHOA MAP2K6 22593214 1803225 Regulation RHOA RGS16 25568667 987495 Regulation RHOA SLC6A2 18509476 2389908 Regulation RHOA SLC6A2 21390328 2506447 Regulation RHOA SLC6A2 21390328 2506461 Regulation RHOA SLC6A2 23828577 563903 Regulation RHOA TNF 21473788 1658074 Regulation RHOA TNF 23365678 2745517 Regulation RHOA UNC5B 19273616 1364462 Regulation RHOA UNC5B 19273616 1364463 Regulation RIC3 OPN1LW 15824136 1319933 Regulation RICTOR FOXO1 24498161 2918737 Regulation RICTOR TLR7 24740015 2954181 Regulation RING1 EPHB2 22870894 802974 Regulation RINL MUSK 21419809 158710 Regulation RIPK3 TNF 24098568 2858188 Regulation RIPK3 TNF 24535827 1416606 Regulation RN7SK EPHB2 23658523 3061200 Regulation RNASE1 ABCC1 16585272 1328699 Regulation RNASE1 ABCC1 16585272 1328796 Regulation RNASE1 ASIP 15647500 2015310 Regulation RNASE1 GPER1 22902561 1877837 Regulation RNASE1 KCNH4 20137095 375082 Regulation RNASE1 MCOLN1 19814799 3212880 Regulation RNASE1 NOP10 21747919 2534206 Regulation RNASE1 NOP10 21747919 2534460 Regulation RNASE1 NOP14 21747919 2534208 Regulation RNASE1 NOP14 21747919 2534462 Regulation RNASE1 NOP16 21747919 2534210 Regulation RNASE1 NOP16 21747919 2534464 Regulation RNASE1 NOP2 21747919 2534212 Regulation RNASE1 NOP2 21747919 2534466 Regulation RNASE1 NOP56 21747919 2534207 Regulation RNASE1 NOP56 21747919 2534461 Regulation RNASE1 NOP58 21747919 2534211 Regulation RNASE1 NOP58 21747919 2534465 Regulation RNASE1 NOP9 21747919 2534209 Regulation RNASE1 NOP9 21747919 2534463 Regulation RNASE1 PCBD1 25101113 896587 Regulation RNASE1 PCNA 19015152 2037487 Regulation RNASE1 PCNA 19015152 2037488 Regulation RNASE1 PCNA 21245041 2059791 Regulation RNASE1 PCNA 21245041 2059792 Regulation RNASE1 PCNA 21245041 2059876 Regulation RNASE1 PCNA 21245041 2059951 Regulation RNASE1 PRPH2 21994660 3219589 Regulation RNASE1 TERT 21053045 599643 Regulation RNASE7 ABCC1 16585272 1328707 Regulation RNASE7 ABCC1 16585272 1328804 Regulation RNASE7 ASIP 15647500 2015318 Regulation RNASE7 EGFR 24747887 2955898 Regulation RNASE7 GPER1 22902561 1877845 Regulation RNASE7 IL17A 23555696 2774934 Regulation RNASE7 KCNH4 20137095 375090 Regulation RNASE7 MCOLN1 19814799 3212888 Regulation RNASE7 MYLIP 23469087 2761401 Regulation RNASE7 MYLIP 23469087 2761405 Regulation RNASE7 MYLIP 23469087 2761413 Regulation RNASE7 MYLIP 23469087 2761414 Regulation RNASE7 NOP10 21747919 2534276 Regulation RNASE7 NOP10 21747919 2534516 Regulation RNASE7 NOP14 21747919 2534278 Regulation RNASE7 NOP14 21747919 2534518 Regulation RNASE7 NOP16 21747919 2534280 Regulation RNASE7 NOP16 21747919 2534520 Regulation RNASE7 NOP2 21747919 2534282 Regulation RNASE7 NOP2 21747919 2534522 Regulation RNASE7 NOP56 21747919 2534277 Regulation RNASE7 NOP56 21747919 2534517 Regulation RNASE7 NOP58 21747919 2534281 Regulation RNASE7 NOP58 21747919 2534521 Regulation RNASE7 NOP9 21747919 2534279 Regulation RNASE7 NOP9 21747919 2534519 Regulation RNASE7 PCBD1 25101113 896595 Regulation RNASE7 PCNA 19015152 2037503 Regulation RNASE7 PCNA 19015152 2037504 Regulation RNASE7 PCNA 21245041 2059807 Regulation RNASE7 PCNA 21245041 2059808 Regulation RNASE7 PCNA 21245041 2059884 Regulation RNASE7 PCNA 21245041 2059959 Regulation RNASE7 PRPH2 21994660 3219597 Regulation RNASE7 STAT3 23555696 2774907 Regulation RNASE7 STAT3 23555696 2774925 Regulation RNASE7 TERT 21053045 599651 Regulation RND3 EPHB2 23208503 2150240 Regulation RND3 MAP2K6 23208503 2150246 Regulation RNF146 AXIN2 24454854 2910171 Regulation RNF146 MMP7 24454854 2910186 Regulation RNF19A ARSA 24586486 2925126 Regulation RNF19A EPHB2 21253577 3050562 Regulation RNF19A EPHB2 23762330 2803044 Regulation RNF19A MAP2K6 15642743 1534183 Regulation RNF19A MAP2K6 20026657 1369845 Regulation RNF19A MAP2K6 22164285 2580318 Regulation RNF19A PTGER2 25327961 216547 Regulation RNF19A TLR7 22984582 2689186 Regulation RNF19A TNF 23731466 357369 Regulation RNF19A TNFSF10 24466325 2914333 Regulation RNF4 HAS3 20805883 2471576 Regulation RNU1-4 TNF 22067318 788599 Regulation ROCK1 CCND1 22070920 1863890 Regulation ROCK2 CCND1 22070920 1863891 Regulation ROR1 WNT7A 24204697 2873501 Regulation RORC AHR 22888330 903096 Regulation RORC ARNTL 18454201 2305291 Regulation RORC ARNTL 18454201 2305308 Regulation RORC ARNTL 18454201 2305314 Regulation RORC ARNTL 18454201 2305322 Regulation RORC BATF 21151104 1954780 Regulation RORC BATF 21151104 1954788 Regulation RORC CDC73 22013287 1749594 Regulation RORC CLOCK 18454201 2305290 Regulation RORC CLOCK 18454201 2305307 Regulation RORC CLOCK 18454201 2305321 Regulation RORC CTR9 22013287 1749595 Regulation RORC EOMES 23383714 988000 Regulation RORC FOXO1 21825017 1564594 Regulation RORC IL10 21518800 1563636 Regulation RORC IL6 21131965 1954688 Regulation RORC IL7 21825017 1564595 Regulation RORC IRF4 21151104 1954779 Regulation RORC IRF4 21151104 1954787 Regulation RORC KLF2 21825017 1564596 Regulation RORC LEO1 22013287 1749598 Regulation RORC MYLIP 23359619 2744992 Regulation RORC NOTCH1 22430492 1567844 Regulation RORC NOTCH2 22430492 1567845 Regulation RORC NOTCH3 22430492 1567846 Regulation RORC NOTCH4 22430492 1567847 Regulation RORC PAF1 22013287 1749596 Regulation RORC RUNX1 21151104 1954765 Regulation RORC TCF3 21131965 1954695 Regulation RORC WDR61 22013287 1749597 Regulation RPAP1 STK39 22303389 881822 Regulation RPE TNF 23922887 2827197 Regulation RPL17 CCND1 24886298 734634 Regulation RPL17 TLR7 21706028 1961437 Regulation RPL17 TLR7 25279955 3012269 Regulation RPL23A FHL1 21045055 2057814 Regulation RPS10 FHL1 17937820 233657 Regulation RPS10 FHL1 20122284 402300 Regulation RPS11 FHL1 17937820 233658 Regulation RPS11 FHL1 20122284 402302 Regulation RPS12 FHL1 17937820 233659 Regulation RPS12 FHL1 20122284 402304 Regulation RPS13 FHL1 17937820 233660 Regulation RPS13 FHL1 20122284 402306 Regulation RPS14 FHL1 17937820 233661 Regulation RPS14 FHL1 20122284 402308 Regulation RPS15 FHL1 17937820 233662 Regulation RPS15 FHL1 20122284 402310 Regulation RPS16 FHL1 17937820 233663 Regulation RPS16 FHL1 20122284 402312 Regulation RPS17 FHL1 17937820 233664 Regulation RPS17 FHL1 20122284 402314 Regulation RPS18 FHL1 17937820 233665 Regulation RPS18 FHL1 20122284 402316 Regulation RPS19 FHL1 17937820 233666 Regulation RPS19 FHL1 20122284 402318 Regulation RPS2 FHL1 17937820 233667 Regulation RPS2 FHL1 20122284 402320 Regulation RPS20 FAS 22929310 1506543 Regulation RPS20 FHL1 17937820 233668 Regulation RPS20 FHL1 20122284 402322 Regulation RPS21 EPHB2 22715416 2653054 Regulation RPS21 FHL1 17937820 233669 Regulation RPS21 FHL1 20122284 402324 Regulation RPS23 FHL1 17937820 233670 Regulation RPS23 FHL1 20122284 402326 Regulation RPS24 FHL1 17937820 233671 Regulation RPS24 FHL1 20122284 402328 Regulation RPS25 FHL1 17937820 233672 Regulation RPS25 FHL1 20122284 402330 Regulation RPS26 FHL1 17937820 233673 Regulation RPS26 FHL1 20122284 402332 Regulation RPS27 FHL1 17937820 233674 Regulation RPS27 FHL1 20122284 402334 Regulation RPS28 FHL1 17937820 233675 Regulation RPS28 FHL1 20122284 402336 Regulation RPS29 FHL1 17937820 233676 Regulation RPS29 FHL1 20122284 402338 Regulation RPS3 FHL1 17937820 233677 Regulation RPS3 FHL1 20122284 402340 Regulation RPS5 FHL1 17937820 233678 Regulation RPS5 FHL1 20122284 402342 Regulation RPS6 EPHB2 25500906 2160848 Regulation RPS6 FHL1 17937820 233679 Regulation RPS6 FHL1 20122284 402344 Regulation RPS6KA3 HES2 PMC4099718 661361 Regulation RPS6KA4 EPHB2 23675462 2793061 Regulation RPS6KA5 EPHB2 12769834 369172 Regulation RPS6KA5 EPHB2 22312244 1094822 Regulation RPS6KB1 TNF 22257771 3160829 Regulation RPS7 FHL1 17937820 233680 Regulation RPS7 FHL1 20122284 402346 Regulation RPS8 FHL1 17937820 233681 Regulation RPS8 FHL1 20122284 402348 Regulation RPS9 FHL1 17937820 233682 Regulation RPS9 FHL1 20122284 402350 Regulation RPTOR EPHB2 21200439 2489529 Regulation RPTOR EPHB2 21283628 2497013 Regulation RPTOR EPHB2 22028687 860564 Regulation RPTOR EPHB2 23077579 2704797 Regulation RPTOR EPHB2 23077579 2704798 Regulation RPTOR EPHB2 23077579 2704799 Regulation RPTOR EPHB2 23077579 2704812 Regulation RPTOR EPHB2 23197407 779559 Regulation RPTOR EPHB2 23431403 2755376 Regulation RPTOR EPHB2 23431403 2755435 Regulation RPTOR EPHB2 23754976 930934 Regulation RPTOR EPHB2 24303063 2887912 Regulation RPTOR FOXO1 22489168 1095456 Regulation RPTOR FOXO1 23183047 1570158 Regulation RPTOR MAP2K6 22564882 2180137 Regulation RPTOR PGC 24352740 2212463 Regulation RPTOR RAB31 22523661 1670386 Regulation RUNX1 EPHB2 22253733 2587789 Regulation RUNX1 EPHB2 24681962 219080 Regulation RUNX2 EPHB2 22433113 1675706 Regulation RUNX2 EPHB2 22942680 1096711 Regulation RUNX2 FOXO1 25187705 1138333 Regulation RUNX2 TNF 22396737 2608367 Regulation RUNX2 TNF 22396737 2608457 Regulation RUNX2 TNF 24592264 911246 Regulation RUNX2 TNF 24743742 573948 Regulation RUNX2 TNF 24743742 574053 Regulation RUNX2 TNF 25228904 914151 Regulation RUNX2 ZFP57 21173110 1383436 Regulation RUNX2 ZFP57 21173110 1383437 Regulation RUNX2 ZFP57 21173110 1383438 Regulation RUNX2 ZFP57 23569325 1571527 Regulation RYK AXIN2 21814488 2276970 Regulation S100A12 EDN2 22046339 2566499 Regulation S100A12 EPHB2 21933441 1898412 Regulation S100A12 EPHB2 21933441 1898414 Regulation S100A12 EPHB2 21933441 1898419 Regulation S100A2 TP63 18388131 2034130 Regulation S100A4 EPHB2 23383075 2747894 Regulation S100A7 EGF 18320059 2384877 Regulation S100A7 EGF 18320059 2384883 Regulation S100A7 EPHB2 20689826 2457884 Regulation S100A7 IFNG 17986321 250450 Regulation S100A7 IFNG 17986321 250451 Regulation S100A7 IFNG 17986321 250469 Regulation S100A7 IFNG 17986321 250471 Regulation S100A7 IFNG 17986321 250475 Regulation S100A7 IL17A 24901012 1621731 Regulation S100A7 IL22 24901012 1621730 Regulation S100A7 IL5 25621169 1727230 Regulation S100A7 STAT1 17986321 250468 Regulation S100A7 STAT3 20689826 2457883 Regulation S100A7 TNF 24901012 1621729 Regulation S100A8 EPHB2 22817771 472016 Regulation S100A8 EPHB2 22817771 472028 Regulation S100A8 JAG1 25144746 3001215 Regulation S100A8 TNF 19232095 507914 Regulation S100A9 LEMD1 20098622 2437820 Regulation S100A9 TNF 21738489 2325073 Regulation S100B AGTR1 21970823 1659862 Regulation S100B CA2 20827422 513037 Regulation S100B CA2 20827422 513097 Regulation S100B CA2 20827422 513117 Regulation S100B DST 18245062 3129638 Regulation S100B EPO 20948886 661403 Regulation S100B FPR2 23164356 1895676 Regulation S100B GCG 20672003 512954 Regulation S100B HOXC11 21654685 436849 Regulation S100B INS 20631894 512950 Regulation S100B MCM2 18042286 1003070 Regulation S100B MCM3 18042286 1003071 Regulation S100B MLST8 25221943 3007220 Regulation S100B MOK 23164356 1895677 Regulation S100B MTOR 25221943 3007222 Regulation S100B NCOA1 21654685 436850 Regulation S100B OPN1MW 22163000 2577782 Regulation S100B RPS6KB1 25221943 3007208 Regulation S100B RPTOR 25221943 3007221 Regulation S100B SOX10 25536222 3035722 Regulation S100B SOX10 25536222 3035724 Regulation S100B SOX9 25536222 3035766 Regulation S100B TXNIP 22474421 832761 Regulation S100G IL1B 25049477 136116 Regulation S100G IL1B 25049477 136117 Regulation S100G IL1B 25049477 136118 Regulation S100G IL1B 25049477 136119 Regulation S1PR1 EPHB2 21686182 1091072 Regulation S1PR2 SPHK1 20573281 285308 Regulation S1PR3 EPHB2 21686182 1091073 Regulation S1PR3 HSPG2 20573281 285309 Regulation S1PR3 MBTPS1 21687504 950266 Regulation S1PR3 MBTPS1 21687504 950269 Regulation S1PR3 MBTPS1 22788716 3161150 Regulation S1PR3 PIK3CA 24324439 963046 Regulation S1PR3 PIK3R1 24324439 963047 Regulation S1PR3 SMAD1 20089836 1773256 Regulation S1PR3 SMAD1 20089836 1773257 Regulation S1PR3 SMAD1 24970177 208738 Regulation S1PR3 SMAD1 25198418 3005982 Regulation S1PR3 SMAD2 20089836 1773258 Regulation S1PR3 SMAD2 20089836 1773259 Regulation S1PR3 SMAD2 24970177 208739 Regulation S1PR3 SMAD2 25198418 3005983 Regulation S1PR3 SMAD3 20089836 1773260 Regulation S1PR3 SMAD3 20089836 1773261 Regulation S1PR3 SMAD3 24970177 208740 Regulation S1PR3 SMAD3 25198418 3005984 Regulation S1PR3 SMAD4 20089836 1773262 Regulation S1PR3 SMAD4 20089836 1773263 Regulation S1PR3 SMAD4 24970177 208741 Regulation S1PR3 SMAD4 25198418 3005985 Regulation S1PR3 SMAD5 20089836 1773264 Regulation S1PR3 SMAD5 20089836 1773265 Regulation S1PR3 SMAD5 24970177 208742 Regulation S1PR3 SMAD5 25198418 3005986 Regulation S1PR3 SMAD6 20089836 1773266 Regulation S1PR3 SMAD6 20089836 1773267 Regulation S1PR3 SMAD6 24970177 208743 Regulation S1PR3 SMAD6 25198418 3005987 Regulation S1PR3 SMAD7 20089836 1773268 Regulation S1PR3 SMAD7 20089836 1773269 Regulation S1PR3 SMAD7 24970177 208744 Regulation S1PR3 SMAD7 25198418 3005988 Regulation S1PR3 SMAD9 20089836 1773270 Regulation S1PR3 SMAD9 20089836 1773271 Regulation S1PR3 SMAD9 24970177 208745 Regulation S1PR3 SMAD9 25198418 3005989 Regulation S1PR3 VEGFA 24970169 208642 Regulation SAA1 GPR115 22731103 1663667 Regulation SAA1 GPR132 22731103 1663656 Regulation SAA1 GPR87 22731103 1663736 Regulation SAA1 TNF 18816405 324209 Regulation SAA1 TNF 24651840 2937270 Regulation SAA1 TNF 24651840 2937273 Regulation SAA3P TNF 19925655 327022 Regulation SCARA3 APOB 21850203 1057519 Regulation SCARA3 GTF2B 24681887 1982650 Regulation SCARB1 ARSA 20137092 1722983 Regulation SCARB1 PDZK1 16197558 2013436 Regulation SCARB1 PDZK1 19654867 2422721 Regulation SCARB1 PDZK1 19956623 2432306 Regulation SCARB1 PDZK1 20515451 2112666 Regulation SCARB1 PDZK1 23936087 2829380 Regulation SCARB1 PDZK1 23936087 2829381 Regulation SCARB1 PDZK1 23936087 2829382 Regulation SCARB1 PDZK1 23936087 2829383 Regulation SCARB1 PDZK1 23936087 2829391 Regulation SCARB1 PDZK1 23936087 2829392 Regulation SCARB1 TNFSF10 24466325 2914325 Regulation SCARB1 TNFSF10 24466325 2914327 Regulation SCARB1 TNFSF10 24466325 2914336 Regulation SCARB1 TNFSF10 24466325 2914338 Regulation SCARNA5 ID1 24137437 2165751 Regulation SCARNA5 TNFSF10 22942757 1097363 Regulation SCARNA5 TNFSF10 22942757 1097364 Regulation SCD FAS 20525346 1723067 Regulation SCD FAS 25590576 2301617 Regulation SCG2 EDN2 21955788 405628 Regulation SCG3 EDN2 21955788 405634 Regulation SCG5 EDN2 21955788 405631 Regulation SCGB1A1 TNF PMC3643277 3225814 Regulation SCGB1D4 FOXO1 20975207 28373 Regulation SCGB1D4 FOXO1 22511947 2619013 Regulation SCGB1D4 FOXO1 22949833 1097929 Regulation SCGB3A1 NFYA 18194566 371322 Regulation SCGB3A1 NFYB 18194566 371323 Regulation SCGB3A1 NFYC 18194566 371324 Regulation SCIN CA2 1331119 1297605 Regulation SCIN CA2 1331119 1297606 Regulation SCIN GSN 22676183 363465 Regulation SCN5A FOXO1 23393573 2751193 Regulation SCRIB EPHB2 23359326 2744892 Regulation SCRIB EPHB2 23359326 2744938 Regulation SCT CST6 22323296 1800329 Regulation SCT CST6 22323296 1800330 Regulation SCT CST6 22323296 1800331 Regulation SDC1 MMP28 22346752 3055658 Regulation SDC1 MMP7 22346752 3055673 Regulation SDC2 EPHB2 17548511 1341005 Regulation SEA TNF 16614521 1634738 Regulation SEC14L2 CAPN8 21516125 2139314 Regulation SEC23IP TNF 7525608 1436369 Regulation SEC61B PGC 21475702 1238428 Regulation SELE CHI3L1 7540655 1590362 Regulation SELE EPHB2 23457623 2759211 Regulation SELE HES2 24891765 1759439 Regulation SELE ITGB2 22291096 1567031 Regulation SELE NT5E 20181103 1625938 Regulation SELE PECAM1 9314541 1463952 Regulation SELE SELL 7682218 1438771 Regulation SELE TNF 23929007 87352 Regulation SELE TNF 23987139 412467 Regulation SELE TNF 24228622 359351 Regulation SELE TNF 24429403 1709600 Regulation SELE TNF 8386742 1595102 Regulation SELE TNF 8691131 1598235 Regulation SELL ADAM17 24602331 660686 Regulation SELL AKT1 23183047 1570121 Regulation SELL AKT2 23183047 1570122 Regulation SELL AKT3 23183047 1570123 Regulation SELL ANG 25369284 3022287 Regulation SELL AOC3 9254657 1601429 Regulation SELL APC 25268140 3011351 Regulation SELL ARSE 11097205 702046 Regulation SELL BCR 22888331 903174 Regulation SELL CALM3 11785676 702308 Regulation SELL CALM3 19823572 2268692 Regulation SELL CD69 23658623 2789213 Regulation SELL CD79A 22888331 903175 Regulation SELL CD79B 22888331 903176 Regulation SELL CDC73 1315317 1297511 Regulation SELL CSF2 2040651 1375877 Regulation SELL CSF2 7512970 1435288 Regulation SELL CSF2 7515891 1435482 Regulation SELL CSF2 7542512 702515 Regulation SELL CSF3 23251603 2729149 Regulation SELL CTLA4 23752227 1572493 Regulation SELL CTR9 1315317 1297512 Regulation SELL CTTN 21788407 1564376 Regulation SELL EDN1 18029384 90723 Regulation SELL FOXO1 18978794 1951892 Regulation SELL FOXO1 22654881 901224 Regulation SELL FOXO1 22888331 903196 Regulation SELL FOXO1 23183047 1570119 Regulation SELL FOXO3 22888331 903197 Regulation SELL FOXO3 23183047 1570120 Regulation SELL FOXO4 22888331 903198 Regulation SELL FOXO4 23183047 1570125 Regulation SELL FOXO6 22888331 903195 Regulation SELL FOXO6 23183047 1570116 Regulation SELL FOXP3 18998771 2265395 Regulation SELL FUT4 14597733 1529408 Regulation SELL FUT4 14597733 1529416 Regulation SELL FUT4 14597733 1529419 Regulation SELL FUT7 14597733 1529409 Regulation SELL HRG PMC4273748 661376 Regulation SELL IFN1@ 7506267 1435149 Regulation SELL IFN1@ 7506267 1435150 Regulation SELL IFN1@ 7506267 1435152 Regulation SELL IFN1@ 7506267 1435156 Regulation SELL IFN1@ 7506267 1435157 Regulation SELL IL1A 7506267 1435161 Regulation SELL IL2 7506267 1435162 Regulation SELL IL21 18286285 487864 Regulation SELL IL6 7506267 1435163 Regulation SELL ITGAM 23573259 2778015 Regulation SELL KLF2 19412182 1952453 Regulation SELL KLF2 21966447 2558004 Regulation SELL KLF2 24843022 756825 Regulation SELL KLF2 24843022 756826 Regulation SELL LEO1 1315317 1297515 Regulation SELL LGALS3 23576987 952937 Regulation SELL MED1 18472871 1742393 Regulation SELL MED10 18472871 1742388 Regulation SELL MED11 18472871 1742391 Regulation SELL MED13 18472871 1742375 Regulation SELL MED13L 18472871 1742376 Regulation SELL MED14 18472871 1742380 Regulation SELL MED15 18472871 1742369 Regulation SELL MED16 18472871 1742371 Regulation SELL MED17 18472871 1742382 Regulation SELL MED18 18472871 1742387 Regulation SELL MED19 18472871 1742390 Regulation SELL MED20 18472871 1742370 Regulation SELL MED21 18472871 1742367 Regulation SELL MED22 18472871 1742368 Regulation SELL MED23 18472871 1742381 Regulation SELL MED24 18472871 1742377 Regulation SELL MED25 18472871 1742389 Regulation SELL MED26 18472871 1742383 Regulation SELL MED27 18472871 1742384 Regulation SELL MED29 18472871 1742379 Regulation SELL MED30 18472871 1742378 Regulation SELL MED31 18472871 1742386 Regulation SELL MED4 18472871 1742372 Regulation SELL MED6 18472871 1742373 Regulation SELL MED7 18472871 1742385 Regulation SELL MED8 18472871 1742374 Regulation SELL MLST8 23183047 1570117 Regulation SELL MTOR 23183047 1570124 Regulation SELL MTOR 23369601 3190685 Regulation SELL OPA1 18472871 1742392 Regulation SELL PAF1 1315317 1297513 Regulation SELL PLG 21364954 2504546 Regulation SELL PLG 21364954 2504547 Regulation SELL PODXL 22016802 2562904 Regulation SELL PRG2 20140097 2440051 Regulation SELL PRG3 20140097 2440052 Regulation SELL PRG4 20140097 2440053 Regulation SELL RPTOR 23183047 1570118 Regulation SELL SETD2 23183047 1570115 Regulation SELL SETD2 23183047 1570235 Regulation SELL TLN1 7538138 1436694 Regulation SELL TLN2 7538138 1436696 Regulation SELL TLR1 24499202 34914 Regulation SELL TLR10 24499202 34922 Regulation SELL TLR2 23409051 2753328 Regulation SELL TLR2 23409051 2753332 Regulation SELL TLR2 24499202 34915 Regulation SELL TLR3 24499202 34916 Regulation SELL TLR4 24499202 34917 Regulation SELL TLR5 24499202 34918 Regulation SELL TLR6 24499202 34923 Regulation SELL TLR7 24499202 34919 Regulation SELL TLR8 24499202 34920 Regulation SELL TLR9 23409051 2753329 Regulation SELL TLR9 23409051 2753333 Regulation SELL TLR9 24499202 34921 Regulation SELL TNF 17355628 108155 Regulation SELL TNF 7506267 1435160 Regulation SELL VCL 7538138 1436695 Regulation SELL WDR61 1315317 1297514 Regulation SELP HES2 20028511 659386 Regulation SELP SELL 8909556 1457696 Regulation SEMA5A PLAU 23661031 735570 Regulation SENP2 NES 22031293 1795933 Regulation SERPINA5 ARNTL2 23148642 339573 Regulation SERPINA5 LTBP1 23148642 339574 Regulation SERPINB2 PLAT 9303361 446603 Regulation SERPINB2 TNF 9607921 1602827 Regulation SERPINB3 INPP4B 24500884 492411 Regulation SERPINB3 TNF 11044363 418037 Regulation SERPINB3 TNF 21858034 2545811 Regulation SERPINB3 TNF 23379751 267661 Regulation SERPINB5 F2R 21378407 2175466 Regulation SERPINB5 F2R 21378407 2175467 Regulation SERPINB5 F2R 21378407 2175482 Regulation SERPINB5 F2R 22266725 14440 Regulation SERPINB6 TNF 25136575 197178 Regulation SERPINE1 EPHB2 17474984 656552 Regulation SERPINE1 EPHB2 17474984 656553 Regulation SERPINE1 EPHB2 20204159 1671942 Regulation SERPINE1 JAG1 23494120 83891 Regulation SERPINE1 MAP2K6 20204159 1671948 Regulation SERPINE1 MAP2K6 24707477 188406 Regulation SERPINE1 PLAU 10817507 417102 Regulation SERPINE1 PLAU 16091756 426323 Regulation SERPINE1 PLAU 16091756 426324 Regulation SERPINE1 PLAU 23766912 3081248 Regulation SERPINE1 RCAN1 23825664 2809894 Regulation SERPINE1 RCAN1 23825664 2809934 Regulation SERPINE1 RCAN1 23825664 2809940 Regulation SERPINE1 SRGN 24286332 222298 Regulation SERPINE1 SRGN 24286332 222299 Regulation SERPINE1 SRGN 24286332 222302 Regulation SERPINE1 TNF 21494547 2512955 Regulation SERPINE1 TNF 21494547 2512974 Regulation SERPINF1 TNF 24367624 2900358 Regulation SERPINF1 TNF 24367624 2900364 Regulation SERPINF1 TNF 24367624 2900381 Regulation SERPINF1 TNF 24367624 2900409 Regulation SERPINF1 TNF 24367624 2900413 Regulation SERPINF1 TNF 24367624 2900415 Regulation SETD2 EGLN3 21291529 467123 Regulation SETD2 EGLN3 22007214 1673212 Regulation SETD2 EGLN3 24386269 2903413 Regulation SETD2 EGLN3 25010988 576860 Regulation SETD2 EPHB2 19406746 1165854 Regulation SETD2 EPHB2 21544242 2517404 Regulation SETD2 EPHB2 21544242 2517482 Regulation SETD2 EPHB2 21980400 2560261 Regulation SETD2 EPHB2 21980400 2560326 Regulation SETD2 EPHB2 23342124 2742497 Regulation SETD2 EPHB2 23469202 2763190 Regulation SETD2 FOXO1 21696576 260288 Regulation SETD2 FOXO1 21696576 260289 Regulation SETD2 FOXO1 23183047 1570138 Regulation SETD2 ID1 18519801 706205 Regulation SETD2 OSR1 21209911 2492227 Regulation SETD2 PECAM1 22607554 3091502 Regulation SETD2 STK39 21234295 648187 Regulation SETD2 TFPI2 23282899 3225396 Regulation SETD2 TLR7 22870988 126595 Regulation SETD2 TLR7 23282899 3225386 Regulation SETD2 TLR7 PMC4088757 661310 Regulation SETD2 TNF 21298084 2320977 Regulation SETD2 TNF 25075575 454114 Regulation SF3B3 IFI27 23951410 170569 Regulation SF3B5 SMN2 22110043 2070059 Regulation SFTPA2 SNCAIP 23924898 1817706 Regulation SFTPC TGM2 24244820 204961 Regulation SFXN1 CD14 17242961 810075 Regulation SFXN1 EPHB2 25148033 3001316 Regulation SGK1 FOXO1 23786484 32869 Regulation SGK1 FOXO1 23786484 33240 Regulation SH2B1 AGR2 22174895 2582479 Regulation SH3D19 EPHB2 22267161 1967398 Regulation SHBG TNF 19209274 3176892 Regulation SHBG TNF 22210320 721057 Regulation SHC1 EPHB2 24349153 2896879 Regulation SHH ANGPT1 23894369 2824422 Regulation SHH ANGPT1 23894369 2824427 Regulation SHH MAP2K6 23935925 2828448 Regulation SHH MSX1 23316168 960778 Regulation SHH PLAT 22432023 2611595 Regulation SHH PLAT 22432023 2611608 Regulation SHH WNT7A 18355805 697131 Regulation SIAH1 EGLN3 24809345 2358909 Regulation SIAH1 EPHB2 21076532 1674766 Regulation SIAH2 EGLN3 24809345 2358914 Regulation SIAH2 EPHB2 21076532 1674767 Regulation SIAH3 EPHB2 21076532 1674771 Regulation SIGIRR IL1R2 22973499 1764568 Regulation SIGIRR TLR7 22973499 1764562 Regulation SIGLEC1 TNF 21040544 3111648 Regulation SIGLEC10 TNF 21040544 3111652 Regulation SIGLEC11 TNF 21040544 3111654 Regulation SIGLEC12 TNF 21040544 3111650 Regulation SIGLEC14 TNF 21040544 3111660 Regulation SIGLEC15 TNF 21040544 3111658 Regulation SIGLEC16 TNF 21040544 3111656 Regulation SIGLEC5 TNF 21040544 3111638 Regulation SIGLEC6 TNF 21040544 3111640 Regulation SIGLEC7 TNF 21040544 3111642 Regulation SIGLEC7 TNF 21519548 85492 Regulation SIGLEC8 TNF 21040544 3111644 Regulation SIGLEC9 TNF 21040544 3111646 Regulation SIL1 MMP28 24549119 503020 Regulation SIL1 MMP7 24549119 503035 Regulation SIRT1 ALDH2 24040162 2846028 Regulation SIRT1 ALDH2 24040162 2846031 Regulation SIRT1 FOXO1 24843827 589699 Regulation SIRT1 FOXO1 25360511 2119077 Regulation SIRT1 FOXO1 25386563 1496742 Regulation SIRT1 PGC 20157548 25882 Regulation SIRT1 PGC 22829833 1068746 Regulation SIRT1 PGC 23326623 2225408 Regulation SIRT1 PGC 23326623 2225410 Regulation SIRT1 PGC 23840225 1156415 Regulation SIRT1 PGC 24069505 2226981 Regulation SIRT1 PGC 24822191 190564 Regulation SIRT1 PGC 24990154 3144003 Regulation SIRT1 TNF 22447223 14584 Regulation SIRT1 TNF 22447223 14585 Regulation SIRT1 TNF 22447223 14586 Regulation SIRT3 ACSS1 22087287 2571277 Regulation SIRT3 PGC 20661474 2456752 Regulation SIRT3 PGC 20661474 2456753 Regulation SIRT3 PGC 20661474 2456754 Regulation SIRT3 PGC 20661474 2456780 Regulation SIRT3 PGC 20661474 2456781 Regulation SIRT3 PGC 21901160 2550243 Regulation SIRT3 PGC 23075607 30917 Regulation SIRT3 PGC 23800187 1868860 Regulation SIRT3 PGC 23840225 1156412 Regulation SIRT3 PGC 23840225 1156417 Regulation SIRT3 PGC 24837835 1126935 Regulation SIRT5 NGFR 23593219 2780364 Regulation SIRT6 TNF 21738489 2325074 Regulation SIX1 MYH16 24852826 2359408 Regulation SIX1 MYH16 24852826 2359409 Regulation SIX1 MYH3 24852826 2359422 Regulation SIX1 MYH3 24852826 2359423 Regulation SKP2 FOXO1 18665269 2394215 Regulation SKP2 IFI27 23029392 2697146 Regulation SLAMF1 TLR7 23882270 908290 Regulation SLC10A3 TNF 17304338 1054721 Regulation SLC12A2 TNF 24916922 1668190 Regulation SLC12A2 TNF 24916922 1668196 Regulation SLC12A2 TNF 24916922 1668198 Regulation SLC12A5 CAPN8 24089642 2003261 Regulation SLC12A5 CLU 24097188 1963615 Regulation SLC12A5 EPHB2 22084630 860767 Regulation SLC12A6 OSR1 24393035 152288 Regulation SLC12A9 CCND1 23620761 2783316 Regulation SLC16A3 BSG 25314297 1131949 Regulation SLC16A3 INS 21779523 2115052 Regulation SLC16A3 SETD2 24363178 606913 Regulation SLC16A6 ARSG 24454846 2910142 Regulation SLC19A1 TNF 22546471 125651 Regulation SLC1A2 EPHB2 24376419 953420 Regulation SLC1A2 TNF 24836816 2971325 Regulation SLC1A2 TNF 25371754 845420 Regulation SLC1A2 TNF 25371754 845421 Regulation SLC1A2 TNF 25371754 845423 Regulation SLC1A5 TNF 25574232 845561 Regulation SLC20A1 CCND1 19808898 787712 Regulation SLC22A3 CCND1 18945340 2001048 Regulation SLC22A3 CCND1 23836980 2121363 Regulation SLC22A3 CEACAM6 25398131 3027589 Regulation SLC22A3 CEACAM6 25398131 3027600 Regulation SLC22A3 CTGF 22747784 380978 Regulation SLC22A3 CTGF 23259759 856346 Regulation SLC22A3 EPHB2 21880137 519995 Regulation SLC22A3 EPHB2 22649777 939971 Regulation SLC22A3 EPHB2 23544048 2773398 Regulation SLC22A3 EPHB2 24568222 1872217 Regulation SLC22A3 EPHB2 24678619 396465 Regulation SLC22A3 FOXA1 23896594 1109472 Regulation SLC22A3 FOXQ1 22761930 2659247 Regulation SLC22A3 FOXQ1 25356753 2206498 Regulation SLC22A3 ID1 24347544 752265 Regulation SLC22A3 ID1 25393508 1134139 Regulation SLC22A3 JAG1 23560082 2776423 Regulation SLC22A3 JAG1 24598126 1618816 Regulation SLC22A3 KLF9 21324165 259216 Regulation SLC22A3 KRT38 23536778 2771559 Regulation SLC22A3 MMP7 20584780 1023285 Regulation SLC22A3 MUC16 21326240 436478 Regulation SLC22A3 MUC16 21326240 436490 Regulation SLC22A3 NEDD9 21829474 2541151 Regulation SLC22A3 PIGR 22025622 1651636 Regulation SLC22A3 PIGR 22025622 1651637 Regulation SLC22A3 PIGR 22025622 1651684 Regulation SLC22A3 PIGR 22025622 1651722 Regulation SLC22A3 PLAU 23984088 1150916 Regulation SLC22A3 PLAU 23984088 1150917 Regulation SLC22A3 PODXL 21533279 2515745 Regulation SLC22A3 TNF 21147546 2220572 Regulation SLC22A3 TNF 21664353 829209 Regulation SLC22A3 TNF 23437179 2755912 Regulation SLC25A20 TLR7 19551144 2419930 Regulation SLC2A1 TNF 23835341 727903 Regulation SLC2A2 FOXO1 22399922 3158698 Regulation SLC2A4 EPHB2 20231899 2443166 Regulation SLC2A4 FAS 20525346 1723068 Regulation SLC2A4 PGC 19696889 2310530 Regulation SLC2A4 PGC 21475702 1238404 Regulation SLC2A4 PGC 22359576 2597737 Regulation SLC2A4 PGC 24199159 730983 Regulation SLC2A4 RAB31 22470488 2614371 Regulation SLC2A4 TNF 23383064 2747757 Regulation SLC2A4 TNF 23835341 727904 Regulation SLC2A4 TNF 24204966 2874983 Regulation SLC2A4RG EPHB2 20824214 2474013 Regulation SLC3A2 EPHB2 22768207 2660173 Regulation SLC44A1 FAS 24578708 1070414 Regulation SLC4A2 MAP2K6 19823673 2428290 Regulation SLC4A2 MAP2K6 19823673 2428291 Regulation SLC6A11 RAB31 24225037 388887 Regulation SLC6A2 CDC5L 11960554 368984 Regulation SLC6A2 CDK1 24339788 2353362 Regulation SLC6A2 CDK2 21690308 1389386 Regulation SLC6A2 PAK2 23864709 1817039 Regulation SLC6A2 PAK2 23864709 1817043 Regulation SLC6A3 EPHB2 22722938 1203934 Regulation SLC6A3 EPHB2 22722938 1203935 Regulation SLC9A1 EPHB2 22904641 490798 Regulation SLC9A2 CISH 24376510 2900981 Regulation SLC9A2 EGR1 24376510 2900973 Regulation SLC9A2 EGR1 24376510 2900984 Regulation SLC9A2 EGR1 24376510 2900985 Regulation SLCO6A1 EPHB2 9432981 1602426 Regulation SLCO6A1 FOXO1 24314125 33281 Regulation SLCO6A1 RNASE1 18509452 2389812 Regulation SLCO6A1 RNASE7 18509452 2389820 Regulation SLCO6A1 TNF 24386331 2903543 Regulation SLFN11 CCND1 25329797 3016329 Regulation SLFN12 CCND1 25329797 3016327 Regulation SLFN13 CCND1 25329797 3016328 Regulation SLFN14 CCND1 25329797 3016331 Regulation SLFN5 CCND1 25329797 3016330 Regulation SLIT2 CCND1 22140553 2576650 Regulation SLK FAS 15219238 523853 Regulation SLPI EPHB2 15691373 524163 Regulation SLPI EPHB2 20668165 1779483 Regulation SLPI EPHB2 22942680 1096713 Regulation SLPI EPHB2 22942680 1096770 Regulation SLPI HBEGF 24136232 568228 Regulation SLPI NES 19696784 785911 Regulation SLPI TNF 24795772 825693 Regulation SLPI TNF 25514790 3034718 Regulation SLPI WNT7A 23497616 3161670 Regulation SMAD1 ANGPT1 25329960 3016936 Regulation SMAD1 EPHB2 19821774 1236710 Regulation SMAD1 EPHB2 22593733 930624 Regulation SMAD1 EPHB2 22593733 930662 Regulation SMAD1 EPHB2 24340017 2894570 Regulation SMAD1 FOXO1 25423188 3030058 Regulation SMAD1 MAP2K6 24340017 2894578 Regulation SMAD1 S1PR3 24970177 208746 Regulation SMAD1 TNF 19087346 3109092 Regulation SMAD1 TNF 24743742 573968 Regulation SMAD1 TNF 24820069 454067 Regulation SMAD1 WIF1 24632949 548681 Regulation SMAD2 ANGPT1 25329960 3016939 Regulation SMAD2 CLU 23157228 230283 Regulation SMAD2 EPHB2 21572418 1925876 Regulation SMAD2 EPHB2 21860657 813117 Regulation SMAD2 EPHB2 21860657 813155 Regulation SMAD2 EPHB2 24340017 2894581 Regulation SMAD2 FOXO1 25423188 3030059 Regulation SMAD2 MAP2K6 21383698 2138600 Regulation SMAD2 MAP2K6 24340017 2894589 Regulation SMAD2 S1PR3 24970177 208747 Regulation SMAD2 TNF 19087346 3109094 Regulation SMAD2 TNF 22313861 3160888 Regulation SMAD2 TNF 23670020 93307 Regulation SMAD2 TNF 24743742 573970 Regulation SMAD2 TNF 24820069 454068 Regulation SMAD3 ANGPT1 25329960 3016942 Regulation SMAD3 CLU 23157228 230284 Regulation SMAD3 EPHB2 21572418 1925877 Regulation SMAD3 EPHB2 21860657 813118 Regulation SMAD3 EPHB2 21860657 813156 Regulation SMAD3 EPHB2 22470391 1992825 Regulation SMAD3 EPHB2 22927969 2681230 Regulation SMAD3 EPHB2 24340017 2894592 Regulation SMAD3 FOXO1 25423188 3030060 Regulation SMAD3 MAP2K6 24340017 2894600 Regulation SMAD3 S1PR3 24970177 208748 Regulation SMAD3 SLC6A2 23828577 563905 Regulation SMAD3 TNF 19087346 3109096 Regulation SMAD3 TNF 24004852 803467 Regulation SMAD3 TNF 24743742 573972 Regulation SMAD3 TNF 24820069 454069 Regulation SMAD4 ANGPT1 25329960 3016945 Regulation SMAD4 EPHB2 21572418 1925878 Regulation SMAD4 EPHB2 21860657 813157 Regulation SMAD4 EPHB2 24340017 2894603 Regulation SMAD4 FOXO1 25423188 3030061 Regulation SMAD4 MAP2K6 24340017 2894611 Regulation SMAD4 S1PR3 24970177 208757 Regulation SMAD4 TNF 19087346 3109098 Regulation SMAD4 TNF 24743742 573974 Regulation SMAD4 TNF 24820069 454070 Regulation SMAD5 ANGPT1 25329960 3016948 Regulation SMAD5 EPHB2 24340017 2894614 Regulation SMAD5 FOXO1 25423188 3030062 Regulation SMAD5 MAP2K6 24340017 2894622 Regulation SMAD5 S1PR3 24970177 208758 Regulation SMAD5 TNF 19087346 3109100 Regulation SMAD5 TNF 24743742 573976 Regulation SMAD5 TNF 24820069 454071 Regulation SMAD6 ANGPT1 25329960 3016951 Regulation SMAD6 EPHB2 24340017 2894625 Regulation SMAD6 FOXO1 25423188 3030063 Regulation SMAD6 MAP2K6 24340017 2894633 Regulation SMAD6 S1PR3 24970177 208759 Regulation SMAD6 TNF 19087346 3109102 Regulation SMAD6 TNF 24743742 573978 Regulation SMAD6 TNF 24820069 454072 Regulation SMAD7 ANGPT1 25329960 3016954 Regulation SMAD7 EPHB2 24340017 2894636 Regulation SMAD7 FOXO1 25423188 3030064 Regulation SMAD7 MAP2K6 24340017 2894644 Regulation SMAD7 S1PR3 24970177 208760 Regulation SMAD7 TF 24236640 450701 Regulation SMAD7 TNF 19087346 3109104 Regulation SMAD7 TNF 24743742 573980 Regulation SMAD7 TNF 24820069 454073 Regulation SMAD9 ANGPT1 25329960 3016957 Regulation SMAD9 EPHB2 24340017 2894647 Regulation SMAD9 FOXO1 25423188 3030065 Regulation SMAD9 MAP2K6 24340017 2894655 Regulation SMAD9 S1PR3 24970177 208761 Regulation SMAD9 TNF 19087346 3109106 Regulation SMAD9 TNF 24743742 573982 Regulation SMAD9 TNF 24820069 454074 Regulation SMARCA2 CCND1 21811517 1239526 Regulation SMARCA2 CCND1 21811517 1239527 Regulation SMARCA2 EPHB2 24811485 2190638 Regulation SMARCA4 EPHB2 21572418 1925870 Regulation SMARCA4 EPHB2 21860657 813149 Regulation SMARCA4 EPHB2 24811485 2190639 Regulation SMARCA4 STAT4 16717115 1540381 Regulation SMARCA4 UCA1 24993775 2171789 Regulation SMARCB1 EPHB2 24811485 2190640 Regulation SMARCC1 EPHB2 21572418 1925871 Regulation SMARCC1 EPHB2 21860657 813150 Regulation SMARCC1 EPHB2 24811485 2190641 Regulation SMARCC2 EPHB2 21572418 1925872 Regulation SMARCC2 EPHB2 21860657 813151 Regulation SMARCC2 EPHB2 24811485 2190642 Regulation SMARCD1 EPHB2 24811485 2190643 Regulation SMARCE1 EPHB2 24811485 2190644 Regulation SMC2 EDN2 22558515 3086174 Regulation SMC2 MAP2K6 22949889 1060708 Regulation SMC3 EDN2 22558515 3086186 Regulation SMC3 MAP2K6 22949889 1060736 Regulation SMC4 EDN2 22558515 3086177 Regulation SMC4 MAP2K6 22949889 1060715 Regulation SMC5 EDN2 22558515 3086180 Regulation SMC5 MAP2K6 22949889 1060722 Regulation SMC6 EDN2 22558515 3086183 Regulation SMC6 MAP2K6 22949889 1060729 Regulation SMN1 EPHB2 22348054 2596652 Regulation SMN1 HBEGF 22330337 1717975 Regulation SMN1 ID1 23320068 2739511 Regulation SMN1 SMN2 21124729 2319953 Regulation SMN1 SMN2 22669976 1203533 Regulation SMN2 BMP1 18791638 2396513 Regulation SMN2 BMP10 18791638 2396521 Regulation SMN2 BMP15 18791638 2396514 Regulation SMN2 BMP2 18791638 2396515 Regulation SMN2 BMP3 18791638 2396516 Regulation SMN2 BMP4 18791638 2396517 Regulation SMN2 BMP5 18791638 2396518 Regulation SMN2 BMP6 18791638 2396519 Regulation SMN2 BMP7 18791638 2396520 Regulation SMN2 CAPN1 21209906 2492081 Regulation SMN2 CAPN10 21209906 2492082 Regulation SMN2 CAPN11 21209906 2492083 Regulation SMN2 CAPN12 21209906 2492080 Regulation SMN2 CAPN13 21209906 2492091 Regulation SMN2 CAPN14 21209906 2492092 Regulation SMN2 CAPN15 21209906 2492079 Regulation SMN2 CAPN2 21209906 2492084 Regulation SMN2 CAPN3 21209906 2492085 Regulation SMN2 CAPN5 21209906 2492086 Regulation SMN2 CAPN6 21209906 2492087 Regulation SMN2 CAPN7 21209906 2492088 Regulation SMN2 CAPN8 21209906 2492089 Regulation SMN2 CAPN9 21209906 2492090 Regulation SMN2 CAST 21209906 2492013 Regulation SMN2 COP 23284781 2730966 Regulation SMN2 CREB1 25514431 3034552 Regulation SMN2 CREB3 25514431 3034553 Regulation SMN2 CREB5 25514431 3034551 Regulation SMN2 CRK 24405637 2221783 Regulation SMN2 DHX9 11149922 1266608 Regulation SMN2 GEMIN2 17640370 280491 Regulation SMN2 GRAP2 24405637 2221763 Regulation SMN2 HNRNPR 23383159 2748566 Regulation SMN2 MECP2 18971205 1031892 Regulation SMN2 MIR137 23615451 1814174 Regulation SMN2 PIEZO1 23615451 1813979 Regulation SMN2 PIEZO1 23615451 1813998 Regulation SMN2 SMN1 21124729 2319956 Regulation SMN2 TET1 22669976 1203550 Regulation SMN2 TET1 22669976 1203791 Regulation SMN2 TET2 22669976 1203548 Regulation SMN2 TET2 22669976 1203789 Regulation SMN2 TET3 22669976 1203549 Regulation SMN2 TET3 22669976 1203790 Regulation SMS TLR7 24009514 3064119 Regulation SMURF2 NEDD9 20825672 585627 Regulation SNAI1 EPHB2 19124656 1553558 Regulation SNAI1 EPHB2 22105351 1393660 Regulation SNAI1 EPHB2 24894949 1942400 Regulation SNAI1 VSNL1 22479362 2614930 Regulation SNAI1 VSNL1 22479362 2614936 Regulation SNAI1 VSNL1 22479362 2614950 Regulation SNAI1 VSNL1 22479362 2614954 Regulation SNAI1 VSNL1 22479362 2614956 Regulation SNAI1 VSNL1 PMC3876944 3038935 Regulation SNAI2 EPHB2 14623871 1301370 Regulation SNAI2 JAG1 17984306 1547589 Regulation SNAI2 MAP2K6 21418646 304905 Regulation SNAI2 NEDD9 21829474 2541155 Regulation SNCA SNCAIP 18366718 359886 Regulation SNCAIP COG2 23418753 1725503 Regulation SNCAIP HDAC6 23284848 2731066 Regulation SNCAIP REL 10770796 1515142 Regulation SNRPA CAPN8 21209906 2492103 Regulation SNRPA1 SMN2 22110043 2070044 Regulation SNRPB CAPN8 21209906 2492117 Regulation SNRPB2 SMN2 22110043 2070049 Regulation SNRPE CCND1 24848372 2972419 Regulation SNX24 IL1B 24268062 522331 Regulation SOAT1 CAPN8 22046434 2567856 Regulation SOAT1 HES2 22530164 2232455 Regulation SOCS1 STAT4 20843320 1858908 Regulation SOCS1 TNF 22739986 556342 Regulation SOCS1 TNF 22973314 1068917 Regulation SOCS1 TNF 24963279 842174 Regulation SOCS1 TNFSF10 20185810 712895 Regulation SOCS3 EPHB2 23782265 151737 Regulation SOCS3 IL1B 18989459 3042188 Regulation SOCS3 STAT4 20843320 1858910 Regulation SOCS3 TNF 22500980 355798 Regulation SOCS3 TNF 22739986 556343 Regulation SOCS3 TNF 25352752 1917454 Regulation SOCS3 TNF 25352752 1917455 Regulation SOCS3 TNF 25352752 1917495 Regulation SOD1 IL1B 11286475 418514 Regulation SOD1 LBP 21541044 1090760 Regulation SOD1 LBP 21541044 1090761 Regulation SOD1 LBP 24454506 825101 Regulation SOD1 NES 22870054 1920657 Regulation SOD1 OSR1 25206429 2004402 Regulation SOD1 PGC 22563483 2626882 Regulation SOD1 TNF 10359573 1511790 Regulation SOD1 TNF 10359573 1511791 Regulation SOD1 TNF 21403844 506732 Regulation SOD1 TNF 7523104 796021 Regulation SOD1 TNF 7705313 796413 Regulation SOD2 CDKN1C 24308935 1158395 Regulation SOD2 FOXO1 22820707 30782 Regulation SOD2 FOXO1 24556689 572286 Regulation SOD2 IL1B 11286475 418515 Regulation SOD2 LBP 21541044 1090762 Regulation SOD2 LBP 21541044 1090763 Regulation SOD2 LBP 24454506 825102 Regulation SOD2 NES 22870054 1920658 Regulation SOD2 OSR1 25206429 2004404 Regulation SOD2 PGC 22563483 2626883 Regulation SOD2 TNF 10359573 1511794 Regulation SOD2 TNF 10359573 1511795 Regulation SOD2 TNF 21403844 506733 Regulation SOD2 TNF 7523104 796022 Regulation SOD2 TNF 7705313 796441 Regulation SOD3 IL1B 11286475 418516 Regulation SOD3 LBP 21541044 1090764 Regulation SOD3 LBP 21541044 1090765 Regulation SOD3 LBP 24454506 825103 Regulation SOD3 NES 22870054 1920659 Regulation SOD3 OSR1 25206429 2004406 Regulation SOD3 PGC 22563483 2626884 Regulation SOD3 TNF 10359573 1511798 Regulation SOD3 TNF 10359573 1511799 Regulation SOD3 TNF 21403844 506734 Regulation SOD3 TNF 25025040 194672 Regulation SOD3 TNF 7523104 796023 Regulation SOD3 TNF 7705313 796469 Regulation SORL1 BDNF 22870188 2671963 Regulation SORL1 GGA1 22621900 1803310 Regulation SOS1 CABP4 24920279 395053 Regulation SOS1 EPHB2 23027900 1400295 Regulation SOS1 EPHB2 23803171 536534 Regulation SOS1 MAP2K6 24324645 2890989 Regulation SOS1 RNASE1 22719885 2653561 Regulation SOS1 RNASE1 22719885 2653585 Regulation SOS1 RNASE1 22719885 2653609 Regulation SOS1 RNASE7 22719885 2653569 Regulation SOS1 RNASE7 22719885 2653593 Regulation SOS1 RNASE7 22719885 2653617 Regulation SOS2 CABP4 24920279 395058 Regulation SOS2 EPHB2 23027900 1400296 Regulation SOS2 EPHB2 23803171 536535 Regulation SOS2 MAP2K6 24324645 2890996 Regulation SOS2 RNASE1 22719885 2653573 Regulation SOS2 RNASE1 22719885 2653597 Regulation SOS2 RNASE1 22719885 2653621 Regulation SOS2 RNASE7 22719885 2653581 Regulation SOS2 RNASE7 22719885 2653605 Regulation SOS2 RNASE7 22719885 2653629 Regulation SOST CTGF 19857613 412953 Regulation SOST EPHB2 21723865 850882 Regulation SOST PTGER2 21723865 850888 Regulation SOST TNF 24286133 130377 Regulation SOX10 NGFR 24799129 2960762 Regulation SOX10 NGFR 24799129 2960769 Regulation SOX11 CCND1 21124928 2484745 Regulation SOX2 EPHB2 24643025 2935534 Regulation SOX2 ID1 24457967 571649 Regulation SOX2 ID1 24457967 571674 Regulation SOX2 IFI27 23217425 615779 Regulation SOX2 JAG1 24465223 2355843 Regulation SOX2 MAP2K6 23009336 1867023 Regulation SOX2 MAP2K6 25340657 2366644 Regulation SOX4 EPHB2 23251334 2727765 Regulation SOX4 EPHB2 23251334 2727827 Regulation SOX4 MAP2K6 23251334 2727771 Regulation SOX4 MAP2K6 23251334 2727835 Regulation SOX6 CREB3L2 24711445 1209129 Regulation SOX9 CHI3L1 PMC2833845 134364 Regulation SOX9 CREB3L2 24711445 1209128 Regulation SOX9 EPHB2 19144181 112423 Regulation SOX9 EPHB2 19144181 112424 Regulation SOX9 EPHB2 20800688 2222092 Regulation SOX9 EPHB2 22761195 2180431 Regulation SOX9 MAP2K6 19144181 112435 Regulation SOX9 MAP2K6 19144181 112436 Regulation SOX9 TNF 18182117 109770 Regulation SOX9 TNF 18182117 109771 Regulation SOX9 TNF 18182117 109772 Regulation SOX9 TNF 18182117 109773 Regulation SOX9 TNF 18182117 109793 Regulation SOX9 TNF 18182117 109795 Regulation SOX9 TNF 18182117 109796 Regulation SOX9 TNF 18182117 109799 Regulation SOX9 TNF 19435506 113280 Regulation SP1 EPHB2 18852899 2397583 Regulation SP1 EPHB2 18852899 2397629 Regulation SP1 EPHB2 21829524 2541617 Regulation SP1 EPHB2 23696862 2795577 Regulation SP1 HBEGF 25060396 492935 Regulation SP1 TNF 22534375 125573 Regulation SP1 TNF 22534375 125574 Regulation SP6 TP63 25166858 2362420 Regulation SP8 TP63 25166858 2362421 Regulation SPAG11B EPHB2 22159280 83841 Regulation SPAG8 EPHB2 22294469 135272 Regulation SPAG8 FOXO1 20975207 28381 Regulation SPAG8 PRSS21 25038180 137198 Regulation SPAG8 TNF 22067318 788601 Regulation SPAG8 TNF 23435016 1691542 Regulation SPAG8 TNF 24367624 2900363 Regulation SPARC CTGF 20359365 118622 Regulation SPARC CTGF 20359365 118625 Regulation SPARC CTGF 23390502 2750818 Regulation SPARC MMP28 24551460 2003428 Regulation SPARC MMP7 24551460 2003443 Regulation SPARC TNFSF10 16622457 427501 Regulation SPC24 FHL1 22496762 2617368 Regulation SPHK1 CA2 16203868 1538016 Regulation SPHK1 CALM3 16203868 1538017 Regulation SPHK1 CEBPB 24597747 1701384 Regulation SPHK1 CORO6 19390594 2415354 Regulation SPHK1 CORO7 19390594 2415355 Regulation SPHK1 CRK 20498849 2451163 Regulation SPHK1 EPHB2 16636149 1329292 Regulation SPHK1 GPER1 16636149 1329264 Regulation SPHK1 IGF1 22788716 3161135 Regulation SPHK1 IL1A 24464131 1959761 Regulation SPHK1 INS 24349009 2896538 Regulation SPHK1 INS 24349009 2896550 Regulation SPHK1 INS 24349009 2896553 Regulation SPHK1 MAPK3 16636149 1329265 Regulation SPHK1 MAPK3 16636149 1329353 Regulation SPHK1 MAPK3 24970177 208693 Regulation SPHK1 MAPK3 24970177 208789 Regulation SPHK1 MBTPS1 20634980 2455733 Regulation SPHK1 MYLIP 24279510 1678942 Regulation SPHK1 PIK3CA 20634980 2455722 Regulation SPHK1 PIK3CA 20634980 2455794 Regulation SPHK1 PIK3R1 20634980 2455723 Regulation SPHK1 PIK3R1 20634980 2455795 Regulation SPHK1 PLD1 22136116 244777 Regulation SPHK1 PLD1 24970177 208790 Regulation SPHK1 PLD2 22136116 244778 Regulation SPHK1 PLD2 24970177 208791 Regulation SPHK1 PLD3 22136116 244773 Regulation SPHK1 PLD3 24970177 208785 Regulation SPHK1 PLD4 22136116 244774 Regulation SPHK1 PLD4 24970177 208786 Regulation SPHK1 PLD5 22136116 244775 Regulation SPHK1 PLD5 24970177 208787 Regulation SPHK1 PLD6 22136116 244776 Regulation SPHK1 PLD6 24970177 208788 Regulation SPHK1 PTK2 25417698 1947388 Regulation SPHK1 PTK6 25417698 1947389 Regulation SPHK1 PTK7 25417698 1947390 Regulation SPHK1 RUNX2 20863401 1859306 Regulation SPHK1 SMAD1 21798099 3160441 Regulation SPHK1 SMAD1 25198418 3005974 Regulation SPHK1 SMAD2 21798099 3160442 Regulation SPHK1 SMAD2 25198418 3005975 Regulation SPHK1 SMAD3 21798099 3160443 Regulation SPHK1 SMAD3 25198418 3005976 Regulation SPHK1 SMAD4 21798099 3160444 Regulation SPHK1 SMAD4 25198418 3005977 Regulation SPHK1 SMAD5 21798099 3160445 Regulation SPHK1 SMAD5 25198418 3005978 Regulation SPHK1 SMAD6 21798099 3160446 Regulation SPHK1 SMAD6 25198418 3005979 Regulation SPHK1 SMAD7 21798099 3160447 Regulation SPHK1 SMAD7 25198418 3005980 Regulation SPHK1 SMAD9 21798099 3160448 Regulation SPHK1 SMAD9 25198418 3005981 Regulation SPHK1 SPHK2 16636149 1329303 Regulation SPHK1 SPHK2 16636149 1329366 Regulation SPHK1 TP53 23028939 2693652 Regulation SPHK1 VEGFA 24970177 208784 Regulation SPHK1 VEGFA 25417698 1947361 Regulation SPHK1 VEGFA 25417698 1947362 Regulation SPHK1 VEGFA 25417698 1947363 Regulation SPHK1 VEGFA 25417698 1947364 Regulation SPHK1 VEGFA 25417698 1947365 Regulation SPHK2 SPHK1 16636149 1329367 Regulation SPP1 MAP2K6 24216994 500832 Regulation SPP1 MMP28 22978720 275088 Regulation SPP1 MMP7 22978720 275103 Regulation SPP1 TNF 24490170 186723 Regulation SPP1 TNF 24490170 186730 Regulation SPR TNF 21085650 2482869 Regulation SPRED2 MAP2K6 24970815 2194290 Regulation SPRR1B SDCBP 25593999 2173505 Regulation SPRR1B SDCBP 25593999 2173506 Regulation SPRR3 IL13 23844115 2819448 Regulation SPRR3 IL4 23844115 2819449 Regulation SPRR3 JUN 24796531 2960570 Regulation SPRR3 NFE2L2 22383093 778345 Regulation SPRR3 NFE2L2 22383093 778346 Regulation SPRR3 STAT6 23844115 2819447 Regulation SPRY4 MAP2K6 24970815 2194325 Regulation SQSTM1 CAPN8 24553345 984548 Regulation SRC ANGPT1 24642125 614209 Regulation SRC CAPN8 18332219 1349982 Regulation SRC CAPN8 23551528 1480305 Regulation SRC CTGF 21760921 2535992 Regulation SRC EPHB2 PMC3363182 391233 Regulation SRC FAS 19190626 431735 Regulation SRC MMP28 23213380 167857 Regulation SRC MMP7 23213380 167872 Regulation SRC TLR7 21911421 1565242 Regulation SRC TNF 24502696 1233369 Regulation SREBF1 EPHB2 23153363 1725112 Regulation SREBF1 FAS 22027268 1724073 Regulation SREBF1 FAS 23382926 2746799 Regulation SREBF1 FAS 24843688 1494552 Regulation SREBF1 FOXO1 21479224 2511297 Regulation SREBF2 FAS 22027268 1724076 Regulation SRF EPHB2 21873936 1735101 Regulation SRF TNF 24386331 2903629 Regulation SRGN GCG 24363554 742883 Regulation SRGN INS 24363554 742884 Regulation SRGN LEP 20522593 713981 Regulation SRGN LEP 20522593 713983 Regulation SRGN MYL2 18086913 1346867 Regulation SRGN MYL2 18086913 1346868 Regulation SRGN ZGLP1 20522593 713982 Regulation SRGN ZGLP1 21885869 719772 Regulation SRGN ZGLP1 23825925 731496 Regulation SRL EPHB2 22315658 1702870 Regulation SRP14 SMN2 23221635 2082704 Regulation SRP19 SMN2 23221635 2082709 Regulation SRP54 SMN2 23221635 2082714 Regulation SRP68 SMN2 23221635 2082719 Regulation SRP72 SMN2 23221635 2082724 Regulation SRP9 SMN2 23221635 2082729 Regulation SRSF11 RNASE1 24914048 2101776 Regulation SRSF11 RNASE7 24914048 2101784 Regulation SST TNF 7502522 3230089 Regulation ST13 PDZK1 21653824 1791345 Regulation ST2 CD14 23429360 838596 Regulation ST3 GNE 20383336 2445908 Regulation STAR EPHB2 22479211 2334479 Regulation STAR EPHB2 24945345 2981098 Regulation STAT1 EPHB2 19895680 1006865 Regulation STAT1 EPHB2 23825585 2809705 Regulation STAT1 EPHB2 23825585 2809749 Regulation STAT1 EPHB2 23825585 2809765 Regulation STAT1 MAP2K6 23825585 2809711 Regulation STAT1 MAP2K6 23825585 2809755 Regulation STAT1 MAP2K6 23825585 2809771 Regulation STAT1 STAT4 17846149 1546999 Regulation STAT1 STAT4 24058795 1705943 Regulation STAT1 TLR7 15851485 1535831 Regulation STAT1 TNF 23401241 780034 Regulation STAT1 TNF 24453411 1756653 Regulation STAT1 TNF 24453411 1756660 Regulation STAT3 ARSA 24901243 2976451 Regulation STAT3 CAPN8 25352693 1713550 Regulation STAT3 CAPN8 25352693 1713551 Regulation STAT3 CAPN8 25352693 1713552 Regulation STAT3 CCND1 22833568 1806162 Regulation STAT3 CCND1 22833568 1806167 Regulation STAT3 EPHB2 12010564 98798 Regulation STAT3 EPHB2 19440292 2416401 Regulation STAT3 EPHB2 21254404 775781 Regulation STAT3 EPHB2 21738764 2533749 Regulation STAT3 EPHB2 22174819 2582279 Regulation STAT3 EPHB2 22213560 3171738 Regulation STAT3 EPHB2 24423131 1507491 Regulation STAT3 EPHB2 24423131 1507564 Regulation STAT3 EPHB2 24533454 271641 Regulation STAT3 EPHB2 24533454 271642 Regulation STAT3 EPHB2 25383546 3024171 Regulation STAT3 MAP2K6 22213560 3171744 Regulation STAT3 MAP2K6 22235275 2585737 Regulation STAT3 MAP2K6 22319590 2595569 Regulation STAT3 MAP2K6 24312439 2889464 Regulation STAT3 TNF 20205746 1656125 Regulation STAT3 TNF 23236394 2726178 Regulation STAT3 TNF 25025494 2989208 Regulation STAT4 CD8A 25336459 1733393 Regulation STAT4 DEF6 10449525 1512292 Regulation STAT4 DEF8 10449525 1512291 Regulation STAT4 DOK1 22514638 2619611 Regulation STAT4 DOK1 22514638 2619632 Regulation STAT4 DOK1 22514638 2619634 Regulation STAT4 EPHB2 19001140 1552784 Regulation STAT4 GATA3 16520391 1539660 Regulation STAT4 GATA3 16520391 1539672 Regulation STAT4 GGT2 22729903 1832225 Regulation STAT4 IL12A 10704465 1514554 Regulation STAT4 IL12A 10952721 1516580 Regulation STAT4 IL12A 12370258 1525019 Regulation STAT4 IL12A 23064011 30891 Regulation STAT4 IL12A 9120388 1601007 Regulation STAT4 IL12B 10704465 1514555 Regulation STAT4 IL12B 10952721 1516581 Regulation STAT4 IL12B 12370258 1525020 Regulation STAT4 IL12B 23064011 30892 Regulation STAT4 IL12B 23469228 2763568 Regulation STAT4 IL12B 9120388 1601008 Regulation STAT4 IL21 12370258 1525011 Regulation STAT4 IL23A 23469228 2763567 Regulation STAT4 JAK2 22110388 1058570 Regulation STAT4 MAP2K1 24106497 696943 Regulation STAT4 MAP3K8 19001140 1552783 Regulation STAT4 MAP3K8 19001140 1552794 Regulation STAT4 NELFCD 23720660 907047 Regulation STAT4 NELFCD 24043764 1573624 Regulation STAT4 NELFCD 24049648 1152239 Regulation STAT4 NELFCD 24199193 184774 Regulation STAT4 PIM1 23209281 1205800 Regulation STAT4 PIM2 23209281 1205801 Regulation STAT4 PIM3 23209281 1205799 Regulation STAT4 STAT1 17846149 1547000 Regulation STAT4 STAT1 24058795 1705944 Regulation STAT4 STAT4 18803832 111222 Regulation STAT4 STAT4 22729903 1832224 Regulation STAT4 TWIST1 22969750 877133 Regulation STAT4 TYK2 22110388 1058569 Regulation STAT5A CAPN8 25352693 1713592 Regulation STAT5A CAPN8 25352693 1713593 Regulation STAT5A CAPN8 25352693 1713594 Regulation STAT5A CCND1 24158537 2185116 Regulation STAT5A CTGF 19152120 1478468 Regulation STAT5A EPHB2 22649371 874963 Regulation STAT5A MAP2K6 22649371 874880 Regulation STAT6 TNF 14638848 1529851 Regulation STEAP4 TNF 24643198 1062550 Regulation STIP1 MMP28 23836498 781155 Regulation STIP1 MMP7 23836498 781171 Regulation STK11 FOXO1 22412893 2609510 Regulation STK32C TNF 24944768 2115579 Regulation STK39 AKT1 21949832 2556704 Regulation STK39 AKT2 21949832 2556705 Regulation STK39 AKT3 21949832 2556706 Regulation STK39 BUB1 24025726 364086 Regulation STK39 BUB1B 24025726 364087 Regulation STK39 BUB3 24025726 364088 Regulation STK39 CA2 21439244 623580 Regulation STK39 CA2 22246465 2170861 Regulation STK39 CALM3 17026765 1845625 Regulation STK39 CALM3 17477876 250125 Regulation STK39 CALM3 21439244 623581 Regulation STK39 CALM3 22246465 2170862 Regulation STK39 CALM3 22645613 1673950 Regulation STK39 CALM3 23114086 625126 Regulation STK39 CALM3 23269878 1712095 Regulation STK39 CALM3 23383130 2748084 Regulation STK39 CALM3 24860643 1770145 Regulation STK39 CDC20 24025726 364089 Regulation STK39 HSP90AB1 22073363 806688 Regulation STK39 HYAL2 15363108 248563 Regulation STK39 LIF 9298977 1463136 Regulation STK39 MAD2L1 24025726 364090 Regulation STK39 PIK3CA 21904677 1139495 Regulation STK39 PIK3CA 24049458 491067 Regulation STK39 PIK3CA 24611016 2122837 Regulation STK39 PIK3R1 21904677 1139496 Regulation STK39 PIK3R1 24049458 491068 Regulation STK39 PIK3R1 24611016 2122838 Regulation STK39 PSMC3 21991300 2561283 Regulation STK39 RHO 11238445 1267442 Regulation STK39 ULK1 22257884 834268 Regulation STK4 FOXO1 24595170 2930842 Regulation STK4 FOXO1 24852423 2972957 Regulation STMN1 EPHB2 20062533 2436732 Regulation STMN1 IFI27 19643027 325855 Regulation STMN3 ID1 25028095 1875733 Regulation STOML2 EPHB2 23667687 2792001 Regulation STOML2 EPHB2 23667687 2792015 Regulation STRAP CAPN8 21209906 2492201 Regulation STS PLAGL1 24260468 2884378 Regulation STX6 RAB31 20347926 833586 Regulation SULT1A3 JAG1 22902754 666525 Regulation SULT2A1 SMN2 24023879 2843949 Regulation SULT2A1 SMN2 24023879 2843964 Regulation SULT2A1 SMN2 24023879 2843974 Regulation SUPT16H TNF 23049873 2699760 Regulation SUV39H1 FOXO1 23435416 2151777 Regulation SWI5 FOXO1 11277966 993997 Regulation SWI5 FOXO1 21689484 404992 Regulation SYCE3 MAP2K6 21411864 2175703 Regulation SYCE3 MAP2K6 23085539 2181488 Regulation SYK CAPN8 14757742 1530862 Regulation SYK TLR7 22496641 3056006 Regulation SYN1 EPHB2 17105652 106853 Regulation SYN1 EPHB2 17105652 106914 Regulation SYN1 EPHB2 17105652 106937 Regulation SYN1 EPHB2 17105652 106998 Regulation SYN1 EPHB2 22942754 1097336 Regulation SYN1 EPHB2 23840629 2815727 Regulation SYN1 WNT7A 25170755 3003872 Regulation SYN2 EPHB2 17105652 106857 Regulation SYN2 EPHB2 17105652 106917 Regulation SYN2 EPHB2 17105652 106938 Regulation SYN2 EPHB2 17105652 107000 Regulation SYN3 EPHB2 17105652 106861 Regulation SYN3 EPHB2 17105652 106920 Regulation SYN3 EPHB2 17105652 106939 Regulation SYN3 EPHB2 17105652 107002 Regulation SYNCRIP LAMB3 22160594 1798625 Regulation SYNCRIP RAB31 18060067 2381138 Regulation SYNGAP1 EPHB2 25426475 950172 Regulation SYNM ACACA 20941370 973509 Regulation SYNM POU6F1 24667541 2938776 Regulation SYNM WAS 23936144 2829503 Regulation SYNM WAS 23936144 2829507 Regulation SYNM WAS 23936144 2829508 Regulation SYNM WAS 23936144 2829509 Regulation SYNPO TNS1 24967628 2983767 Regulation SYT1 EPHB2 25238288 2201168 Regulation SYT1 IL1B 21539730 1626354 Regulation SYT1 TCN1 23936501 2831122 Regulation SYT1 TLR7 23853595 3063024 Regulation SYT1 TNF 17620405 1341839 Regulation SYT1 TNF 20948609 846233 Regulation SYT1 TNF 21539730 1626353 Regulation SYT1 TNF 21904602 2550403 Regulation SYT1 TNF 22096375 1628423 Regulation SYT1 TNF 22384180 2607139 Regulation SYT1 TNF 22384180 2607156 Regulation SYT1 TNF 22754320 1095970 Regulation SYT1 TNF 24024170 3093436 Regulation SYT1 TNF 24371075 1704455 Regulation SYT1 TNF 24371075 1704459 Regulation SYT1 TNF 24371075 1704463 Regulation SYT1 TNF 24614867 2933162 Regulation SYT1 TNF 24614867 2933164 Regulation SYT1 TNF 24616552 1757571 Regulation SYT4 CABP4 16618809 1329021 Regulation SYT8 APP 24086147 2351296 Regulation SYT8 CA2 10545502 1251651 Regulation SYT8 CA2 10974000 1262591 Regulation SYT8 CA2 14580108 3228649 Regulation SYT8 CA2 19597565 934587 Regulation SYT8 CA2 22940675 1977972 Regulation SYT8 CA2 22940675 1977973 Regulation SYT8 CA2 22940675 1978013 Regulation SYT8 CA2 22940675 1978081 Regulation SYT8 CA2 24957080 1654401 Regulation SYT8 CA2 25206473 2004748 Regulation SYT8 INS 23221643 2082812 Regulation SYT8 SNAPIN 23949442 839338 Regulation SYT8 SNAPIN 23949442 839397 Regulation SYT8 SV2A 24937314 1156942 Regulation SYT8 WNT7B 16818724 1331015 Regulation TAB1 TLR7 24498425 2919876 Regulation TAB2 EPHB2 19305426 2124965 Regulation TACC2 TGM2 22944909 1890297 Regulation TACC2 TNF 19052667 162864 Regulation TACC3 TGM2 22944909 1890298 Regulation TACC3 TNF 19052667 162865 Regulation TACR1 EPHB2 21188216 1081593 Regulation TANK TLR7 18411340 1550428 Regulation TANK TNF 18246321 1644004 Regulation TANK TNF 20484576 1776877 Regulation TANK TNF 20484576 1776890 Regulation TANK TNF 21307340 1786603 Regulation TARDBP CAPN8 24369767 809520 Regulation TARDBP SMN2 18957104 385059 Regulation TARS TNF 23425968 3134258 Regulation TARS TNF 23425968 3134259 Regulation TAS2R13 FOXO1 24490110 3151483 Regulation TAS2R38 TLR7 23380647 1024534 Regulation TAT TNF 22039370 1038364 Regulation TAT TNF 22187158 2070778 Regulation TAX1BP1 TNF 19262463 764089 Regulation TBC1D4 AXIN2 22473005 610574 Regulation TBC1D4 RAB31 20410134 1775803 Regulation TBC1D4 TNF 18443205 705811 Regulation TBX21 FOXO1 23712431 1572180 Regulation TCEA1 ANO1 24694595 1823301 Regulation TCEA1 ELOVL4 21139992 1912421 Regulation TCEA1 ELOVL4 21139992 1912423 Regulation TCEA1 ELOVL4 24569140 1637954 Regulation TCEA1 ELOVL4 24571530 361215 Regulation TCEA1 EPHB2 23741474 2801186 Regulation TCEA1 EPHB2 24260264 2883580 Regulation TCEA1 EPHB2 24587210 2929064 Regulation TCEA1 FHL1 18611274 281581 Regulation TCEA1 FOXO1 19555482 235798 Regulation TCEA1 ITGAL 22711877 1568400 Regulation TCEA1 LINC00284 24843027 757021 Regulation TCEA1 LINC00341 24843027 756981 Regulation TCEA1 MAP2K6 24260264 2883589 Regulation TCEA1 NGFR 20156358 402377 Regulation TCEA1 SARM1 21555464 1386914 Regulation TCEA1 SRGN 20032306 1772593 Regulation TCEA1 TMOD1 19752024 1367930 Regulation TCEA1 TMOD1 20737540 694952 Regulation TCEA1 TMOD1 7798317 1441693 Regulation TCEA1 TNF 22615129 1568238 Regulation TCEA1 TNS1 8195290 1445741 Regulation TCF12 ANKRD1 22016770 2562485 Regulation TCF12 CAPN8 24707444 1490766 Regulation TCF12 CCND1 19473496 464252 Regulation TCF12 CCND1 22912670 2677244 Regulation TCF12 CCND1 25143352 785262 Regulation TCF12 EPHB2 20838657 2272388 Regulation TCF12 EPHB2 21253577 3050538 Regulation TCF12 EPHB2 21887232 2548001 Regulation TCF12 EPHB2 22433113 1675707 Regulation TCF12 EPHB2 22808094 2664316 Regulation TCF12 EPHB2 25121739 2997303 Regulation TCF12 EPHB2 25302800 3014503 Regulation TCF12 FOXO1 23712431 1572192 Regulation TCF12 FOXO1 23786484 32949 Regulation TCF12 ID1 24204703 2874093 Regulation TCF12 MAP2K6 17325210 1337729 Regulation TCF12 PGC 24161908 2185131 Regulation TCF12 PGC 24358311 2899500 Regulation TCF12 TLR7 22028588 1222999 Regulation TCF12 TLR7 22358241 653095 Regulation TCF12 TLR7 24977712 2985359 Regulation TCF12 TNF 15987495 104005 Regulation TCF12 TNF 17076895 997495 Regulation TCF12 TNF 20086228 712814 Regulation TCF12 TNF 22267916 983520 Regulation TCF12 TNF 22419908 951367 Regulation TCF12 TNF 22768286 2660422 Regulation TCF12 TNF 23173923 381124 Regulation TCF12 TNF 23874808 2822905 Regulation TCF12 TNF 24926361 844505 Regulation TCF12 ZFP57 23569325 1571779 Regulation TCF15 ANKRD1 22016770 2562487 Regulation TCF15 CAPN8 24707444 1490780 Regulation TCF15 CCND1 19473496 464253 Regulation TCF15 CCND1 22912670 2677246 Regulation TCF15 CCND1 25143352 785263 Regulation TCF15 EPHB2 20838657 2272389 Regulation TCF15 EPHB2 21253577 3050541 Regulation TCF15 EPHB2 21887232 2548002 Regulation TCF15 EPHB2 22433113 1675708 Regulation TCF15 EPHB2 22808094 2664317 Regulation TCF15 EPHB2 25121739 2997304 Regulation TCF15 EPHB2 25302800 3014517 Regulation TCF15 FOXO1 23712431 1572193 Regulation TCF15 FOXO1 23786484 32954 Regulation TCF15 ID1 24204703 2874094 Regulation TCF15 MAP2K6 17325210 1337736 Regulation TCF15 PGC 24161908 2185132 Regulation TCF15 PGC 24358311 2899502 Regulation TCF15 TLR7 22028588 1223009 Regulation TCF15 TLR7 22358241 653105 Regulation TCF15 TLR7 24977712 2985369 Regulation TCF15 TNF 15987495 104006 Regulation TCF15 TNF 17076895 997496 Regulation TCF15 TNF 20086228 712816 Regulation TCF15 TNF 22267916 983524 Regulation TCF15 TNF 22419908 951368 Regulation TCF15 TNF 22768286 2660423 Regulation TCF15 TNF 23173923 381127 Regulation TCF15 TNF 23874808 2822906 Regulation TCF15 TNF 24926361 844506 Regulation TCF15 ZFP57 23569325 1571797 Regulation TCF19 ANKRD1 22016770 2562489 Regulation TCF19 CAPN8 24707444 1490794 Regulation TCF19 CCND1 19473496 464254 Regulation TCF19 CCND1 22912670 2677248 Regulation TCF19 CCND1 25143352 785264 Regulation TCF19 EPHB2 20838657 2272390 Regulation TCF19 EPHB2 21253577 3050544 Regulation TCF19 EPHB2 21887232 2548003 Regulation TCF19 EPHB2 22433113 1675709 Regulation TCF19 EPHB2 22808094 2664318 Regulation TCF19 EPHB2 25121739 2997305 Regulation TCF19 EPHB2 25302800 3014531 Regulation TCF19 FOXO1 23712431 1572194 Regulation TCF19 FOXO1 23786484 32959 Regulation TCF19 ID1 24204703 2874095 Regulation TCF19 MAP2K6 17325210 1337743 Regulation TCF19 PGC 24161908 2185133 Regulation TCF19 PGC 24358311 2899504 Regulation TCF19 TLR7 22028588 1223019 Regulation TCF19 TLR7 22358241 653115 Regulation TCF19 TLR7 24977712 2985379 Regulation TCF19 TNF 15987495 104007 Regulation TCF19 TNF 17076895 997497 Regulation TCF19 TNF 20086228 712818 Regulation TCF19 TNF 22267916 983528 Regulation TCF19 TNF 22419908 951369 Regulation TCF19 TNF 22768286 2660424 Regulation TCF19 TNF 23173923 381130 Regulation TCF19 TNF 23874808 2822907 Regulation TCF19 TNF 24926361 844507 Regulation TCF19 ZFP57 23569325 1571815 Regulation TCF20 ANKRD1 22016770 2562491 Regulation TCF20 CAPN8 24707444 1490808 Regulation TCF20 CCND1 19473496 464255 Regulation TCF20 CCND1 22912670 2677250 Regulation TCF20 CCND1 25143352 785265 Regulation TCF20 EPHB2 20838657 2272391 Regulation TCF20 EPHB2 21253577 3050547 Regulation TCF20 EPHB2 21887232 2548004 Regulation TCF20 EPHB2 22433113 1675710 Regulation TCF20 EPHB2 22808094 2664319 Regulation TCF20 EPHB2 25121739 2997306 Regulation TCF20 EPHB2 25302800 3014545 Regulation TCF20 FOXO1 23712431 1572195 Regulation TCF20 FOXO1 23786484 32964 Regulation TCF20 ID1 24204703 2874096 Regulation TCF20 MAP2K6 17325210 1337750 Regulation TCF20 PGC 24161908 2185134 Regulation TCF20 PGC 24358311 2899506 Regulation TCF20 TLR7 22028588 1223029 Regulation TCF20 TLR7 22358241 653125 Regulation TCF20 TLR7 24977712 2985389 Regulation TCF20 TNF 15987495 104008 Regulation TCF20 TNF 17076895 997498 Regulation TCF20 TNF 20086228 712820 Regulation TCF20 TNF 22267916 983532 Regulation TCF20 TNF 22419908 951370 Regulation TCF20 TNF 22768286 2660425 Regulation TCF20 TNF 23173923 381133 Regulation TCF20 TNF 23874808 2822908 Regulation TCF20 TNF 24926361 844508 Regulation TCF20 ZFP57 23569325 1571833 Regulation TCF21 ANKRD1 22016770 2562493 Regulation TCF21 CAPN8 24707444 1490822 Regulation TCF21 CCND1 19473496 464256 Regulation TCF21 CCND1 22912670 2677252 Regulation TCF21 CCND1 25143352 785266 Regulation TCF21 EPHB2 20838657 2272392 Regulation TCF21 EPHB2 21253577 3050550 Regulation TCF21 EPHB2 21887232 2548005 Regulation TCF21 EPHB2 22433113 1675711 Regulation TCF21 EPHB2 22808094 2664320 Regulation TCF21 EPHB2 25121739 2997307 Regulation TCF21 EPHB2 25302800 3014559 Regulation TCF21 FOXO1 23712431 1572196 Regulation TCF21 FOXO1 23786484 32969 Regulation TCF21 ID1 24204703 2874097 Regulation TCF21 MAP2K6 17325210 1337757 Regulation TCF21 PGC 24161908 2185135 Regulation TCF21 PGC 24358311 2899508 Regulation TCF21 TLR7 22028588 1223039 Regulation TCF21 TLR7 22358241 653135 Regulation TCF21 TLR7 24977712 2985399 Regulation TCF21 TNF 15987495 104009 Regulation TCF21 TNF 17076895 997499 Regulation TCF21 TNF 20086228 712822 Regulation TCF21 TNF 22267916 983536 Regulation TCF21 TNF 22419908 951371 Regulation TCF21 TNF 22768286 2660426 Regulation TCF21 TNF 23173923 381136 Regulation TCF21 TNF 23874808 2822909 Regulation TCF21 TNF 24926361 844509 Regulation TCF21 ZFP57 23569325 1571851 Regulation TCF23 ANKRD1 22016770 2562523 Regulation TCF23 CAPN8 24707444 1490878 Regulation TCF23 CCND1 19473496 464260 Regulation TCF23 CCND1 22912670 2677260 Regulation TCF23 CCND1 25143352 785270 Regulation TCF23 EPHB2 20838657 2272396 Regulation TCF23 EPHB2 21253577 3050577 Regulation TCF23 EPHB2 21887232 2548009 Regulation TCF23 EPHB2 22433113 1675715 Regulation TCF23 EPHB2 22808094 2664324 Regulation TCF23 EPHB2 25121739 2997311 Regulation TCF23 EPHB2 25302800 3014615 Regulation TCF23 FOXO1 23712431 1572200 Regulation TCF23 FOXO1 23786484 32989 Regulation TCF23 ID1 24204703 2874101 Regulation TCF23 MAP2K6 17325210 1337785 Regulation TCF23 PGC 24161908 2185139 Regulation TCF23 PGC 24358311 2899516 Regulation TCF23 TLR7 22028588 1223079 Regulation TCF23 TLR7 22358241 653175 Regulation TCF23 TLR7 24977712 2985439 Regulation TCF23 TNF 15987495 104024 Regulation TCF23 TNF 17076895 997503 Regulation TCF23 TNF 20086228 712831 Regulation TCF23 TNF 22267916 983552 Regulation TCF23 TNF 22419908 951375 Regulation TCF23 TNF 22768286 2660430 Regulation TCF23 TNF 23173923 381161 Regulation TCF23 TNF 23874808 2822914 Regulation TCF23 TNF 24926361 844518 Regulation TCF23 ZFP57 23569325 1571923 Regulation TCF24 ANKRD1 22016770 2562527 Regulation TCF24 CAPN8 24707444 1490906 Regulation TCF24 CCND1 19473496 464262 Regulation TCF24 CCND1 22912670 2677264 Regulation TCF24 CCND1 25143352 785272 Regulation TCF24 EPHB2 20838657 2272398 Regulation TCF24 EPHB2 21253577 3050628 Regulation TCF24 EPHB2 21887232 2548011 Regulation TCF24 EPHB2 22433113 1675717 Regulation TCF24 EPHB2 22808094 2664326 Regulation TCF24 EPHB2 25121739 2997313 Regulation TCF24 EPHB2 25302800 3014643 Regulation TCF24 FOXO1 23712431 1572202 Regulation TCF24 FOXO1 23786484 33023 Regulation TCF24 ID1 24204703 2874103 Regulation TCF24 MAP2K6 17325210 1337799 Regulation TCF24 PGC 24161908 2185141 Regulation TCF24 PGC 24358311 2899520 Regulation TCF24 TLR7 22028588 1223099 Regulation TCF24 TLR7 22358241 653195 Regulation TCF24 TLR7 24977712 2985459 Regulation TCF24 TNF 15987495 104026 Regulation TCF24 TNF 17076895 997505 Regulation TCF24 TNF 20086228 712837 Regulation TCF24 TNF 22267916 983560 Regulation TCF24 TNF 22419908 951377 Regulation TCF24 TNF 22768286 2660433 Regulation TCF24 TNF 23173923 381167 Regulation TCF24 TNF 23874808 2822916 Regulation TCF24 TNF 24926361 844520 Regulation TCF24 ZFP57 23569325 1571959 Regulation TCF25 ANKRD1 22016770 2562525 Regulation TCF25 CAPN8 24707444 1490892 Regulation TCF25 CCND1 19473496 464261 Regulation TCF25 CCND1 22912670 2677262 Regulation TCF25 CCND1 25143352 785271 Regulation TCF25 EPHB2 20838657 2272397 Regulation TCF25 EPHB2 21253577 3050587 Regulation TCF25 EPHB2 21887232 2548010 Regulation TCF25 EPHB2 22433113 1675716 Regulation TCF25 EPHB2 22808094 2664325 Regulation TCF25 EPHB2 25121739 2997312 Regulation TCF25 EPHB2 25302800 3014629 Regulation TCF25 FOXO1 23712431 1572201 Regulation TCF25 FOXO1 23786484 33018 Regulation TCF25 ID1 24204703 2874102 Regulation TCF25 MAP2K6 17325210 1337792 Regulation TCF25 PGC 24161908 2185140 Regulation TCF25 PGC 24358311 2899518 Regulation TCF25 TLR7 22028588 1223089 Regulation TCF25 TLR7 22358241 653185 Regulation TCF25 TLR7 24977712 2985449 Regulation TCF25 TNF 15987495 104025 Regulation TCF25 TNF 17076895 997504 Regulation TCF25 TNF 20086228 712835 Regulation TCF25 TNF 22267916 983556 Regulation TCF25 TNF 22419908 951376 Regulation TCF25 TNF 22768286 2660432 Regulation TCF25 TNF 23173923 381164 Regulation TCF25 TNF 23874808 2822915 Regulation TCF25 TNF 24926361 844519 Regulation TCF25 ZFP57 23569325 1571941 Regulation TCF3 ANKRD1 22016770 2562495 Regulation TCF3 CAPN8 24707444 1490836 Regulation TCF3 CCND1 19473496 464257 Regulation TCF3 CCND1 22912670 2677254 Regulation TCF3 CCND1 25143352 785267 Regulation TCF3 EPHB2 20838657 2272393 Regulation TCF3 EPHB2 21253577 3050553 Regulation TCF3 EPHB2 21887232 2548006 Regulation TCF3 EPHB2 22111016 1151842 Regulation TCF3 EPHB2 22433113 1675712 Regulation TCF3 EPHB2 22808094 2664321 Regulation TCF3 EPHB2 25121739 2997308 Regulation TCF3 EPHB2 25302800 3014573 Regulation TCF3 FOXO1 23712431 1572197 Regulation TCF3 FOXO1 23786484 32974 Regulation TCF3 ID1 24204703 2874098 Regulation TCF3 MAP2K6 17325210 1337764 Regulation TCF3 PGC 24161908 2185136 Regulation TCF3 PGC 24358311 2899510 Regulation TCF3 TLR7 22028588 1223049 Regulation TCF3 TLR7 22358241 653145 Regulation TCF3 TLR7 24977712 2985409 Regulation TCF3 TNF 15987495 104010 Regulation TCF3 TNF 17076895 997500 Regulation TCF3 TNF 20086228 712824 Regulation TCF3 TNF 22267916 983540 Regulation TCF3 TNF 22419908 951372 Regulation TCF3 TNF 22768286 2660427 Regulation TCF3 TNF 23173923 381139 Regulation TCF3 TNF 23874808 2822910 Regulation TCF3 TNF 24926361 844510 Regulation TCF3 ZFP57 23569325 1571869 Regulation TCF4 ANKRD1 22016770 2562497 Regulation TCF4 CAPN8 24707444 1490850 Regulation TCF4 CCND1 19473496 464258 Regulation TCF4 CCND1 22912670 2677256 Regulation TCF4 CCND1 25143352 785268 Regulation TCF4 EPHB2 20838657 2272394 Regulation TCF4 EPHB2 21253577 3050556 Regulation TCF4 EPHB2 21887232 2548007 Regulation TCF4 EPHB2 22433113 1675713 Regulation TCF4 EPHB2 22808094 2664322 Regulation TCF4 EPHB2 25121739 2997309 Regulation TCF4 EPHB2 25302800 3014587 Regulation TCF4 FOXO1 23712431 1572198 Regulation TCF4 FOXO1 23786484 32979 Regulation TCF4 ID1 24204703 2874099 Regulation TCF4 MAP2K6 17325210 1337771 Regulation TCF4 PGC 24161908 2185137 Regulation TCF4 PGC 24358311 2899512 Regulation TCF4 TLR7 22028588 1223059 Regulation TCF4 TLR7 22358241 653155 Regulation TCF4 TLR7 24977712 2985419 Regulation TCF4 TNF 15987495 104011 Regulation TCF4 TNF 17076895 997501 Regulation TCF4 TNF 20086228 712826 Regulation TCF4 TNF 22267916 983544 Regulation TCF4 TNF 22419908 951373 Regulation TCF4 TNF 22768286 2660428 Regulation TCF4 TNF 23173923 381142 Regulation TCF4 TNF 23874808 2822911 Regulation TCF4 TNF 24926361 844511 Regulation TCF4 ZFP57 23569325 1571887 Regulation TCF7 ANKRD1 22016770 2562499 Regulation TCF7 CAPN8 24707444 1490864 Regulation TCF7 CCND1 19473496 464259 Regulation TCF7 CCND1 22912670 2677258 Regulation TCF7 CCND1 25143352 785269 Regulation TCF7 EPHB2 20838657 2272395 Regulation TCF7 EPHB2 21253577 3050559 Regulation TCF7 EPHB2 21887232 2548008 Regulation TCF7 EPHB2 22433113 1675714 Regulation TCF7 EPHB2 22808094 2664323 Regulation TCF7 EPHB2 25121739 2997310 Regulation TCF7 EPHB2 25302800 3014601 Regulation TCF7 FOXO1 23712431 1572199 Regulation TCF7 FOXO1 23786484 32984 Regulation TCF7 ID1 24204703 2874100 Regulation TCF7 MAP2K6 17325210 1337778 Regulation TCF7 PGC 24161908 2185138 Regulation TCF7 PGC 24358311 2899514 Regulation TCF7 TLR7 22028588 1223069 Regulation TCF7 TLR7 22358241 653165 Regulation TCF7 TLR7 24977712 2985429 Regulation TCF7 TNF 15987495 104012 Regulation TCF7 TNF 17076895 997502 Regulation TCF7 TNF 20086228 712828 Regulation TCF7 TNF 22267916 983548 Regulation TCF7 TNF 22419908 951374 Regulation TCF7 TNF 22768286 2660429 Regulation TCF7 TNF 23173923 381145 Regulation TCF7 TNF 23874808 2822912 Regulation TCF7 TNF 24926361 844512 Regulation TCF7 ZFP57 23569325 1571905 Regulation TCN1 AFP 20087354 434424 Regulation TCN1 AFP 20087354 434425 Regulation TCN1 AFP 20087354 434474 Regulation TCN1 AFP 20087354 434492 Regulation TCN1 CD8A 17394654 1620479 Regulation TCN1 CHRFAM7A 8920864 1599466 Regulation TCN1 GRIN1 22579927 2011477 Regulation TCN1 IL7 24147035 2869590 Regulation TCN1 INS 23752133 2110809 Regulation TCN1 NELFCD 25058148 2992053 Regulation TCN1 TRIM26 20087354 434422 Regulation TCN1 TRIM26 20087354 434423 Regulation TCN1 TRIM26 20087354 434488 Regulation TCN1 TRIM26 20087354 434490 Regulation TDGF1P3 CD14 24904837 865241 Regulation TDGF1P3 LBP 1708813 1543159 Regulation TDGF1P3 TNF 17355628 108153 Regulation TEC CHI3L1 22238378 2071492 Regulation TECR TNF 21473788 1658069 Regulation TEK ANGPT1 17803352 2369125 Regulation TERF1 DAPK1 16476779 1327868 Regulation TERF1 ITGB2 17692468 157359 Regulation TERF2 DAPK1 16476779 1327871 Regulation TERF2 ITGB2 17692468 157360 Regulation TERF2 PECAM1 10725328 1256587 Regulation TERF2 TLR7 25118589 1944980 Regulation TERF2IP DAPK1 16476779 1327880 Regulation TERF2IP ITGB2 17692468 157363 Regulation TERF2IP PECAM1 10725328 1256589 Regulation TERF2IP TLR7 25118589 1945084 Regulation TERT ETV7 22291956 2591374 Regulation TERT ZFP57 25032857 577511 Regulation TET1 TNFSF10 22530952 264521 Regulation TET2 PGC 24322296 2096632 Regulation TET2 TNFSF10 22530952 264519 Regulation TET3 PGC 24322296 2096634 Regulation TET3 TNFSF10 22530952 264520 Regulation TF A2M 25057495 195452 Regulation TF ANKS1A 23825523 2809508 Regulation TF ANKS1A 23825523 2809509 Regulation TF BMP1 22701178 1079211 Regulation TF BMP10 22701178 1079219 Regulation TF BMP15 22701178 1079212 Regulation TF BMP2 22701178 1079213 Regulation TF BMP3 22701178 1079214 Regulation TF BMP4 22701178 1079215 Regulation TF BMP5 22701178 1079216 Regulation TF BMP6 22701178 1079217 Regulation TF BMP7 22701178 1079218 Regulation TF CCL2 23343383 127693 Regulation TF CLCN5 19940036 84806 Regulation TF CLIP3 11854307 1279401 Regulation TF CLTA 18974847 2399590 Regulation TF CLTC 18974847 2399591 Regulation TF HFE PMC300675 2288354 Regulation TF IL2 6325575 1585720 Regulation TF KIF3B 19940036 84807 Regulation TF MTOR 17640392 1002336 Regulation TF MTOR 17640392 1002340 Regulation TF S100A8 21589900 3051807 Regulation TF TCF3 23112860 2711227 Regulation TFAM PGC 22072942 1091854 Regulation TFAM PGC 23755172 2801582 Regulation TFAM PGC 24098634 2858241 Regulation TFAM PGC 24344687 2221661 Regulation TFAM PGC 25076854 1063206 Regulation TFAP2A KLF9 10864211 417181 Regulation TFAP2B EPHB2 24766673 1874025 Regulation TFAP2B EPHB2 24766673 1874026 Regulation TFCP2L1 STAT3 23942233 773287 Regulation TFEB EPHB2 22343943 771490 Regulation TFEB EPHB2 22343943 771511 Regulation TFEB EPHB2 22343943 771513 Regulation TFEB PGC 25061009 3203851 Regulation TFF1 FAS 21203528 2490695 Regulation TFF3 MUC16 23306189 2117166 Regulation TFPI2 CDH5 20386594 2445940 Regulation TFPI2 EDC3 24339780 3065247 Regulation TFPI2 EDC4 24339780 3065246 Regulation TFPI2 KLF6 18053161 370971 Regulation TFPI2 LCT 23703216 2088609 Regulation TFPI2 SETD2 23282899 3225395 Regulation TFRC TGM2 22451718 1567882 Regulation TGFB1 IL1B 23049873 2699756 Regulation TGFB1 TNF 23049873 2699755 Regulation TGM2 ABL1 23326482 2740437 Regulation TGM2 ADO 15279680 390118 Regulation TGM2 BCR 23326482 2740434 Regulation TGM2 CA2 22333138 394084 Regulation TGM2 CA2 8013419 796760 Regulation TGM2 CD79A 23326482 2740435 Regulation TGM2 CD79B 23326482 2740436 Regulation TGM2 G0S2 23546556 1141584 Regulation TGM2 IL17A 24116291 204392 Regulation TGM2 MYLIP 22294552 2179646 Regulation TGM2 TGM1 20157411 1712981 Regulation TGM2 TGM2 20157411 1712982 Regulation TGM2 TGM3 20157411 1712983 Regulation TGM2 TGM4 20157411 1712984 Regulation TGM2 TGM5 20157411 1712985 Regulation TGM2 TGM6 20157411 1712986 Regulation TGM2 TGM7 20157411 1712987 Regulation TGS1 EPHB2 24358311 2899461 Regulation TH EPHB2 21808606 933240 Regulation THBS1 ADAMTS1 20546609 256261 Regulation THBS1 ADAMTS1 20546609 256262 Regulation THBS1 ADAMTS1 20546609 256265 Regulation THBS1 ADAMTS1 20546609 256273 Regulation THBS1 CTGF 23950936 2832994 Regulation THBS1 MMP28 23749112 1107538 Regulation THBS1 MMP7 23749112 1107553 Regulation TIAM1 EPHB2 23208503 2150228 Regulation TIAM1 MAP2K6 23208503 2150234 Regulation TIE1 ANGPT1 20208988 1910580 Regulation TIE1 ANGPT1 20554518 1188157 Regulation TIE1 ANGPT1 22125555 1709953 Regulation TIE1 ANGPT1 23405099 2751809 Regulation TIE1 TNF 15535839 101936 Regulation TIMP1 EPHB2 24349206 2897075 Regulation TIMP1 MMP28 12110123 99013 Regulation TIMP1 MMP28 19375502 1731660 Regulation TIMP1 MMP28 20011114 3045793 Regulation TIMP1 MMP28 21217769 12346 Regulation TIMP1 MMP28 21631912 1658488 Regulation TIMP1 MMP28 22230683 398464 Regulation TIMP1 MMP28 24454910 2910337 Regulation TIMP1 MMP28 24681647 1960393 Regulation TIMP1 MMP7 12110123 99028 Regulation TIMP1 MMP7 20011114 3045808 Regulation TIMP1 MMP7 21217769 12361 Regulation TIMP1 MMP7 21631912 1658504 Regulation TIMP1 MMP7 22230683 398479 Regulation TIMP1 MMP7 24454910 2910352 Regulation TIMP1 MMP7 24681647 1960408 Regulation TIMP1 MUC16 20459644 255954 Regulation TIMP1 TLR7 23223421 91290 Regulation TIMP1 TLR7 23223421 91322 Regulation TIMP1 TNF 10408860 414953 Regulation TIMP1 TNF 16106101 1740045 Regulation TIMP1 TNF 16106101 1740046 Regulation TIMP1 TNF 16106101 1740047 Regulation TIMP1 TNF 18852869 1908426 Regulation TIMP1 TNF 21547259 1749156 Regulation TIMP1 TNF 23750094 163623 Regulation TIMP1 TNF 23755201 2801913 Regulation TIMP1 TNF 23967215 2834945 Regulation TIMP1 TNF 25457675 805858 Regulation TIMP1 TNF 8976186 1599726 Regulation TIMP2 MMP28 11250745 457049 Regulation TIMP2 MMP7 11250745 457064 Regulation TIMP2 TNF 16106101 1740048 Regulation TIMP2 TNF 16106101 1740049 Regulation TIMP2 TNF 16106101 1740050 Regulation TIMP2 TNF 24223987 2877527 Regulation TIMP2 TNFSF10 16622457 427502 Regulation TIMP4 TNF 24223987 2877529 Regulation TINF2 DAPK1 16476779 1327874 Regulation TINF2 ITGB2 17692468 157361 Regulation TJP1 ANGPT1 23253477 1401592 Regulation TJP1 ANGPT1 23894369 2824432 Regulation TJP1 CAPN8 22931549 2233401 Regulation TJP1 CAPN8 22931549 2233443 Regulation TJP1 CAPN8 22931549 2233485 Regulation TJP1 EPHB2 24409324 2906887 Regulation TJP1 TNF 19772664 313173 Regulation TLR1 CD14 20236452 659506 Regulation TLR1 CD14 21789185 2537985 Regulation TLR1 CD14 24489448 1757431 Regulation TLR1 CD14 24672516 926396 Regulation TLR1 CD14 25474158 2373485 Regulation TLR1 CD22 22566885 899327 Regulation TLR1 EPHB2 22783258 902332 Regulation TLR1 EPHB2 22783258 902333 Regulation TLR1 EPHB2 22783258 902369 Regulation TLR1 EPHB2 23405061 2751394 Regulation TLR1 EPHB2 24927726 1684605 Regulation TLR1 MAP2K6 23405061 2751647 Regulation TLR1 MAP2K6 23405061 2751691 Regulation TLR1 MX2 22043290 2566010 Regulation TLR1 PDE4B 21288894 1190549 Regulation TLR1 SARM1 21850204 1057542 Regulation TLR1 TLR7 17893200 1547133 Regulation TLR1 TMEM100 23429360 836818 Regulation TLR1 TMEM156 23429360 836836 Regulation TLR1 TMEM211 23429360 836916 Regulation TLR1 TMEM213 23429360 836853 Regulation TLR10 CD14 20236452 659514 Regulation TLR10 CD14 21789185 2537996 Regulation TLR10 CD14 24672516 926404 Regulation TLR10 CD14 25474158 2373501 Regulation TLR10 CD22 22566885 899431 Regulation TLR10 EPHB2 22783258 902356 Regulation TLR10 EPHB2 22783258 902357 Regulation TLR10 EPHB2 22783258 902385 Regulation TLR10 EPHB2 23405061 2751514 Regulation TLR10 EPHB2 24927726 1684647 Regulation TLR10 MX2 22043290 2566018 Regulation TLR10 PDE4B 21288894 1190557 Regulation TLR10 SARM1 21850204 1057550 Regulation TLR10 TMEM100 23429360 838178 Regulation TLR10 TMEM156 23429360 838196 Regulation TLR10 TMEM211 23429360 838276 Regulation TLR10 TMEM213 23429360 838213 Regulation TLR2 CD14 12391013 1525084 Regulation TLR2 CD14 20236452 659507 Regulation TLR2 CD14 21789185 2537986 Regulation TLR2 CD14 21789185 2537987 Regulation TLR2 CD14 23338226 1879468 Regulation TLR2 CD14 23762847 182047 Regulation TLR2 CD14 24489448 1757432 Regulation TLR2 CD14 24672516 926397 Regulation TLR2 CD14 25375272 3070147 Regulation TLR2 CD14 25474158 2373487 Regulation TLR2 CD22 22566885 899340 Regulation TLR2 EDN2 18195069 1548450 Regulation TLR2 EPHB2 22783258 902335 Regulation TLR2 EPHB2 22783258 902336 Regulation TLR2 EPHB2 22783258 902371 Regulation TLR2 EPHB2 23405061 2751409 Regulation TLR2 EPHB2 24927726 1684608 Regulation TLR2 FOXO1 24265696 2884906 Regulation TLR2 MX2 22043290 2566011 Regulation TLR2 PDE4B 21288894 1190550 Regulation TLR2 SARM1 21850204 1057543 Regulation TLR2 TLR7 17893200 1547136 Regulation TLR2 TLR7 24174969 638968 Regulation TLR2 TMEM100 23429360 836988 Regulation TLR2 TMEM156 23429360 837006 Regulation TLR2 TMEM211 23429360 837086 Regulation TLR2 TMEM213 23429360 837023 Regulation TLR2 TNF 14651749 3095631 Regulation TLR2 TNF 16004610 3105091 Regulation TLR2 TNF 16365150 1538965 Regulation TLR2 TNF 18360633 3176739 Regulation TLR2 TNF 19386086 242413 Regulation TLR2 TNF 19693265 2424227 Regulation TLR2 TNF 19835594 3110074 Regulation TLR2 TNF 21408103 2370952 Regulation TLR2 TNF 21949655 3053588 Regulation TLR2 TNF 23304186 637139 Regulation TLR2 TNF 24961692 1733015 Regulation TLR2 TP63 16365150 1538966 Regulation TLR3 CD14 20236452 659481 Regulation TLR3 CD14 20236452 659508 Regulation TLR3 CD14 21789185 2537988 Regulation TLR3 CD14 24672516 926398 Regulation TLR3 CD14 25474158 2373489 Regulation TLR3 CD22 22566885 899353 Regulation TLR3 EPHB2 22783258 902338 Regulation TLR3 EPHB2 22783258 902339 Regulation TLR3 EPHB2 22783258 902373 Regulation TLR3 EPHB2 23405061 2751424 Regulation TLR3 EPHB2 24927726 1684622 Regulation TLR3 MX2 22043290 2566012 Regulation TLR3 PDE4B 21288894 1190551 Regulation TLR3 SARM1 21850204 1057544 Regulation TLR3 TLR7 17893200 1547139 Regulation TLR3 TMEM100 23429360 837158 Regulation TLR3 TMEM156 23429360 837176 Regulation TLR3 TMEM211 23429360 837256 Regulation TLR3 TMEM213 23429360 837193 Regulation TLR4 ALOX5 25116953 2996584 Regulation TLR4 CAPN8 24489676 2915681 Regulation TLR4 CAPN8 24489676 2915751 Regulation TLR4 CAPN8 24489676 2915788 Regulation TLR4 CD14 14517279 1529121 Regulation TLR4 CD14 20236452 659509 Regulation TLR4 CD14 21356084 354405 Regulation TLR4 CD14 21789185 2537990 Regulation TLR4 CD14 23055921 3059519 Regulation TLR4 CD14 23209313 1570373 Regulation TLR4 CD14 24010102 2234933 Regulation TLR4 CD14 24244872 2233926 Regulation TLR4 CD14 24672516 926399 Regulation TLR4 CD14 25474158 2373491 Regulation TLR4 CD22 22566885 899366 Regulation TLR4 EPHB2 22783258 902341 Regulation TLR4 EPHB2 22783258 902342 Regulation TLR4 EPHB2 22783258 902375 Regulation TLR4 EPHB2 23405061 2751439 Regulation TLR4 EPHB2 24927726 1684625 Regulation TLR4 FOXO1 24265696 2884910 Regulation TLR4 LBP 21356084 354407 Regulation TLR4 MX2 22043290 2566013 Regulation TLR4 PDE4B 21288894 1190552 Regulation TLR4 SARM1 21850204 1057545 Regulation TLR4 TLR7 18282141 650989 Regulation TLR4 TLR7 20051129 3110187 Regulation TLR4 TLR7 20051129 3110229 Regulation TLR4 TLR7 21152080 2486076 Regulation TLR4 TLR7 21789185 2538033 Regulation TLR4 TLR7 22916010 3059137 Regulation TLR4 TLR7 24174969 638978 Regulation TLR4 TLR7 24814708 145459 Regulation TLR4 TMEM100 23429360 837328 Regulation TLR4 TMEM156 23429360 837346 Regulation TLR4 TMEM211 23429360 837426 Regulation TLR4 TMEM213 23429360 837363 Regulation TLR4 TNF 14651749 3095632 Regulation TLR4 TNF 18498620 352183 Regulation TLR4 TNF 19997599 2432942 Regulation TLR4 TNF 20202224 1227991 Regulation TLR4 TNF 22823589 337051 Regulation TLR4 TNF 23133376 3059967 Regulation TLR4 TNF 25566447 1498425 Regulation TLR5 CD14 20236452 659510 Regulation TLR5 CD14 21789185 2537991 Regulation TLR5 CD14 24672516 926400 Regulation TLR5 CD14 25474158 2373493 Regulation TLR5 CD22 22566885 899379 Regulation TLR5 EPHB2 22783258 902344 Regulation TLR5 EPHB2 22783258 902345 Regulation TLR5 EPHB2 22783258 902377 Regulation TLR5 EPHB2 23405061 2751454 Regulation TLR5 EPHB2 24927726 1684639 Regulation TLR5 MX2 22043290 2566014 Regulation TLR5 PDE4B 21288894 1190553 Regulation TLR5 SARM1 21850204 1057546 Regulation TLR5 TLR7 17893200 1547143 Regulation TLR5 TLR7 22545147 2624175 Regulation TLR5 TLR7 22545147 2624185 Regulation TLR5 TLR7 22545147 2624195 Regulation TLR5 TMEM100 23429360 837498 Regulation TLR5 TMEM156 23429360 837516 Regulation TLR5 TMEM211 23429360 837596 Regulation TLR5 TMEM213 23429360 837533 Regulation TLR6 CD14 20236452 659515 Regulation TLR6 CD14 21789185 2537997 Regulation TLR6 CD14 23338226 1879469 Regulation TLR6 CD14 24672516 926405 Regulation TLR6 CD14 25474158 2373503 Regulation TLR6 CD22 22566885 899444 Regulation TLR6 EPHB2 22783258 902359 Regulation TLR6 EPHB2 22783258 902360 Regulation TLR6 EPHB2 22783258 902387 Regulation TLR6 EPHB2 23405061 2751529 Regulation TLR6 EPHB2 24927726 1684649 Regulation TLR6 MX2 22043290 2566019 Regulation TLR6 PDE4B 21288894 1190558 Regulation TLR6 SARM1 21850204 1057551 Regulation TLR6 TMEM100 23429360 838348 Regulation TLR6 TMEM156 23429360 838366 Regulation TLR6 TMEM211 23429360 838446 Regulation TLR6 TMEM213 23429360 838383 Regulation TLR7 ACD 25118589 1945046 Regulation TLR7 ADIPOQ 22095690 1033546 Regulation TLR7 AHR 19703987 1556097 Regulation TLR7 AHSA1 22783258 902346 Regulation TLR7 AHSA1 22783258 902378 Regulation TLR7 AHSA1 23405061 2751467 Regulation TLR7 AHSA1 24927726 1684640 Regulation TLR7 AKT1 21738617 2532910 Regulation TLR7 AKT1 21738617 2533048 Regulation TLR7 AKT2 21738617 2532911 Regulation TLR7 AKT2 21738617 2533049 Regulation TLR7 AKT3 21738617 2532912 Regulation TLR7 AKT3 21738617 2533050 Regulation TLR7 APOB 23349676 2742938 Regulation TLR7 ARF6 23060951 654207 Regulation TLR7 ATF3 21152039 2485921 Regulation TLR7 B2M 19075287 1553104 Regulation TLR7 BAMBI 20706677 979197 Regulation TLR7 BCL10 23799152 2807363 Regulation TLR7 BCR 22566885 899497 Regulation TLR7 BMX 18947379 111790 Regulation TLR7 BST2 21994744 3219922 Regulation TLR7 BTK 18947379 111791 Regulation TLR7 BTK 23967355 2837729 Regulation TLR7 BTK 25170774 3003993 Regulation TLR7 C5AR1 24814708 145475 Regulation TLR7 CARD9 18200499 807242 Regulation TLR7 CBL 23056470 2701698 Regulation TLR7 CCND2 18180309 1548209 Regulation TLR7 CD14 20236452 659511 Regulation TLR7 CD14 21789185 2537993 Regulation TLR7 CD14 24672516 926401 Regulation TLR7 CD14 25474158 2373495 Regulation TLR7 CD180 18847495 111626 Regulation TLR7 CD180 22661952 957382 Regulation TLR7 CD19 PMC4184230 2236350 Regulation TLR7 CD22 22566885 899392 Regulation TLR7 CD36 25474158 2373496 Regulation TLR7 CD44 23940791 2832468 Regulation TLR7 CDC73 20976181 2479287 Regulation TLR7 CEBPD 24747529 2955882 Regulation TLR7 CHUK 24527057 825277 Regulation TLR7 CISH 19300567 2011638 Regulation TLR7 CISH 23078795 1617596 Regulation TLR7 CISH 23144910 2714847 Regulation TLR7 CSF1 18219369 1083668 Regulation TLR7 CSF1 23533994 180622 Regulation TLR7 CSF2 19426550 282595 Regulation TLR7 CSF2 19426550 282667 Regulation TLR7 CSF3 18219369 1083669 Regulation TLR7 CSF3 23882270 908300 Regulation TLR7 CTNNBL1 24134665 3210752 Regulation TLR7 CTR9 20976181 2479288 Regulation TLR7 CXCL10 23144947 2715099 Regulation TLR7 DES 24039815 2844850 Regulation TLR7 DLD 23675052 1064393 Regulation TLR7 DOCK2 20231379 1557666 Regulation TLR7 DOCK2 20231379 1557745 Regulation TLR7 DOK1 22761938 2659323 Regulation TLR7 DOK2 22761938 2659324 Regulation TLR7 DOK3 22761938 2659320 Regulation TLR7 DOK3 22761938 2659423 Regulation TLR7 DOK4 22761938 2659319 Regulation TLR7 DOK5 22761938 2659318 Regulation TLR7 DOK6 22761938 2659322 Regulation TLR7 DOK7 22761938 2659321 Regulation TLR7 EEF1A2 20396414 1747351 Regulation TLR7 ELL 22174696 2328022 Regulation TLR7 EPHB2 22783258 902347 Regulation TLR7 EPHB2 22783258 902348 Regulation TLR7 EPHB2 22783258 902379 Regulation TLR7 EPHB2 23405061 2751469 Regulation TLR7 EPHB2 24927726 1684641 Regulation TLR7 FLII 23555084 180763 Regulation TLR7 FLT1 25486609 3032881 Regulation TLR7 HAVCR2 23967307 2835915 Regulation TLR7 HCK 18947379 111793 Regulation TLR7 HLA-A 19075287 1553102 Regulation TLR7 HMOX1 18234118 110125 Regulation TLR7 HRAS 23565202 2777232 Regulation TLR7 HSPG2 24856829 222966 Regulation TLR7 IFNAR1 17893202 1547193 Regulation TLR7 IGKV1-27 18268035 1549219 Regulation TLR7 IGKV1-27 21964925 600401 Regulation TLR7 IGKV1-27 23047678 1934413 Regulation TLR7 IGKV1-27 23429360 837779 Regulation TLR7 IGKV1-27 24459463 910879 Regulation TLR7 IGKV1-27 24917867 913091 Regulation TLR7 IKBKB 24527057 825278 Regulation TLR7 IKBKG 23825957 3062923 Regulation TLR7 IKBKG 24527057 825279 Regulation TLR7 IL10 20625435 2455116 Regulation TLR7 IL10 20625435 2455137 Regulation TLR7 IL12A 15007094 1531670 Regulation TLR7 IL12A 16365150 1539060 Regulation TLR7 IL12B 15007094 1531671 Regulation TLR7 IL12B 16365150 1539061 Regulation TLR7 IL23A 15007094 1531669 Regulation TLR7 IL32 22613074 125939 Regulation TLR7 IL4 24489947 2917079 Regulation TLR7 IL4 24489947 2917111 Regulation TLR7 INPP5D 22876243 902769 Regulation TLR7 INPP5D 23078795 1617384 Regulation TLR7 INS 18556339 729036 Regulation TLR7 IRAK1 15767370 1534890 Regulation TLR7 IRAK1 15767370 1534902 Regulation TLR7 IRAK1 15767370 1534920 Regulation TLR7 IRAK1 16606665 1539946 Regulation TLR7 IRAK1 16606665 1539969 Regulation TLR7 IRAK1 20929569 403298 Regulation TLR7 IRAK1 21188194 139566 Regulation TLR7 IRAK1 21639951 122808 Regulation TLR7 IRAK1 22393448 2608258 Regulation TLR7 IRAK1 23078795 1617562 Regulation TLR7 IRAK2 21998578 3053699 Regulation TLR7 IRAK2 22393448 2608259 Regulation TLR7 IRAK3 16316467 1624864 Regulation TLR7 IRAK3 20929569 403297 Regulation TLR7 IRAK3 21390243 1049854 Regulation TLR7 IRAK3 21811575 2539607 Regulation TLR7 IRAK3 22393448 2608255 Regulation TLR7 IRAK3 22737610 2161078 Regulation TLR7 IRAK3 23437317 2756448 Regulation TLR7 IRAK3 23776703 2805639 Regulation TLR7 IRAK3 23776703 2805672 Regulation TLR7 IRAK4 17470642 1545495 Regulation TLR7 IRAK4 17470642 1545496 Regulation TLR7 IRAK4 17470642 1545527 Regulation TLR7 IRAK4 17485511 1545730 Regulation TLR7 IRAK4 17893200 1547146 Regulation TLR7 IRAK4 17893200 1547169 Regulation TLR7 IRAK4 19689377 694806 Regulation TLR7 IRAK4 21197425 979797 Regulation TLR7 IRAK4 22393448 2608256 Regulation TLR7 IRAK4 23994464 1051352 Regulation TLR7 IRAK4 25034608 3144657 Regulation TLR7 IRAK4 25034608 3144668 Regulation TLR7 IRF4 24009023 1110981 Regulation TLR7 IRF5 19108028 3231574 Regulation TLR7 IRF5 21826793 776703 Regulation TLR7 IRF5 25076492 2993372 Regulation TLR7 KLRAP1 19075287 1553103 Regulation TLR7 KLRAP1 20934454 1042670 Regulation TLR7 KRAS 23565202 2777233 Regulation TLR7 KRR1 22661952 957463 Regulation TLR7 LEO1 20976181 2479291 Regulation TLR7 LGALS9 23967307 2835916 Regulation TLR7 LILRA2 22479404 2615209 Regulation TLR7 LPA 23349676 2742939 Regulation TLR7 LRRFIP1 23435233 3222258 Regulation TLR7 LTB 24634497 1624551 Regulation TLR7 LY96 25415198 3224429 Regulation TLR7 LYN PMC4291836 541295 Regulation TLR7 MALT1 23799152 2807362 Regulation TLR7 MAP3K5 21064192 775633 Regulation TLR7 MAP3K8 19667062 1555633 Regulation TLR7 MAPK1 23405061 2751470 Regulation TLR7 MAPK10 23405061 2751471 Regulation TLR7 MAPK11 23405061 2751472 Regulation TLR7 MAPK12 23405061 2751473 Regulation TLR7 MAPK13 23405061 2751474 Regulation TLR7 MAPK14 23405061 2751475 Regulation TLR7 MAPK15 23405061 2751468 Regulation TLR7 MAPK3 23405061 2751476 Regulation TLR7 MAPK4 23405061 2751477 Regulation TLR7 MAPK6 23405061 2751478 Regulation TLR7 MAPK7 23405061 2751479 Regulation TLR7 MAPK8 23405061 2751480 Regulation TLR7 MAPK9 23405061 2751481 Regulation TLR7 MAPKAP1 24740015 2954116 Regulation TLR7 MAPKAP1 24740015 2954498 Regulation TLR7 MEI1 19564352 1555231 Regulation TLR7 MEI1 19564352 1555232 Regulation TLR7 MEI4 19564352 1555233 Regulation TLR7 MEI4 19564352 1555234 Regulation TLR7 MIF 21977228 2559805 Regulation TLR7 MIF 23046560 339424 Regulation TLR7 MKL1 19300567 2011636 Regulation TLR7 MLST8 24740015 2954117 Regulation TLR7 MLST8 24740015 2954499 Regulation TLR7 MRE11A 25118589 1944210 Regulation TLR7 MSC 22745793 2656504 Regulation TLR7 MTA1 25117662 2996757 Regulation TLR7 MTA2 25117662 2996758 Regulation TLR7 MTA3 25117662 2996756 Regulation TLR7 MTOR 24740015 2954119 Regulation TLR7 MTOR 24740015 2954501 Regulation TLR7 MUC1 24968021 2984016 Regulation TLR7 MX2 22043290 2566015 Regulation TLR7 MYD88 15223603 1739704 Regulation TLR7 MYD88 17553156 1002256 Regulation TLR7 MYD88 18268035 1549115 Regulation TLR7 MYD88 18268035 1549116 Regulation TLR7 MYD88 18268035 1549169 Regulation TLR7 MYD88 18268035 1549220 Regulation TLR7 MYD88 18268035 1549304 Regulation TLR7 MYD88 18824587 1552221 Regulation TLR7 MYD88 18947379 111708 Regulation TLR7 MYD88 19079579 3042875 Regulation TLR7 MYD88 20396389 1747334 Regulation TLR7 MYD88 20661430 3048187 Regulation TLR7 MYD88 21197425 979819 Regulation TLR7 MYD88 21390243 1049855 Regulation TLR7 MYD88 21496301 1658230 Regulation TLR7 MYD88 21747787 923027 Regulation TLR7 MYD88 21893536 2250047 Regulation TLR7 MYD88 21931552 3053381 Regulation TLR7 MYD88 21943186 3112625 Regulation TLR7 MYD88 21998578 3053700 Regulation TLR7 MYD88 22074389 354833 Regulation TLR7 MYD88 22661952 957464 Regulation TLR7 MYD88 22737610 2161067 Regulation TLR7 MYD88 22928050 2681753 Regulation TLR7 MYD88 22973499 1764589 Regulation TLR7 MYD88 22985132 3226486 Regulation TLR7 MYD88 23055935 3059617 Regulation TLR7 MYD88 23299509 1022883 Regulation TLR7 MYD88 23471913 740247 Regulation TLR7 MYD88 23483993 2764961 Regulation TLR7 MYD88 23483993 2764986 Regulation TLR7 MYD88 23484159 179786 Regulation TLR7 MYD88 23527272 2770339 Regulation TLR7 MYD88 23527272 2770384 Regulation TLR7 MYD88 23527272 2770426 Regulation TLR7 MYD88 23758787 1649526 Regulation TLR7 MYD88 24386204 2903242 Regulation TLR7 MYD88 24489933 2916906 Regulation TLR7 MYD88 24586659 2925997 Regulation TLR7 MYD88 24705038 2948732 Regulation TLR7 MYD88 24797940 2960681 Regulation TLR7 MYD88 25076492 2993388 Regulation TLR7 MYD88 25170774 3003974 Regulation TLR7 MYD88 25232836 3008146 Regulation TLR7 MYD88 25312698 1491661 Regulation TLR7 MYD88 PMC3332402 134739 Regulation TLR7 MYLIP 21188194 139565 Regulation TLR7 MYLIP 22393448 2608257 Regulation TLR7 MYLIP 22518321 1079148 Regulation TLR7 MYLIP 22661952 957462 Regulation TLR7 MYLIP 23468661 2343502 Regulation TLR7 MYLIP 23468661 2343503 Regulation TLR7 MYLIP 23506673 1036568 Regulation TLR7 MYLIP 24705038 2948774 Regulation TLR7 MYLIP 24705038 2948775 Regulation TLR7 MYLIP 24800233 190020 Regulation TLR7 MYLIP 24932654 2980363 Regulation TLR7 NDP 21964925 600402 Regulation TLR7 NELFCD 16365150 1539059 Regulation TLR7 NELFCD 22927956 2681207 Regulation TLR7 NELFCD 24244362 2879690 Regulation TLR7 NEU1 25187624 761468 Regulation TLR7 NEU1 25187624 761469 Regulation TLR7 NFAT5 23867654 839189 Regulation TLR7 NFKB1 21044333 659718 Regulation TLR7 NINJ1 PMC3504845 661152 Regulation TLR7 NLRP3 24966466 1759759 Regulation TLR7 NOD2 21750585 1918436 Regulation TLR7 NOD2 21750585 1918437 Regulation TLR7 NOD2 22114704 2573545 Regulation TLR7 NOD2 23977330 2840030 Regulation TLR7 NOD2 24459463 910878 Regulation TLR7 NOD2 25423082 3029852 Regulation TLR7 NOD2 25423082 3029877 Regulation TLR7 NOTCH1 22610140 1957483 Regulation TLR7 NOTCH2 22610140 1957484 Regulation TLR7 NOTCH3 22610140 1957485 Regulation TLR7 NOTCH4 22610140 1957486 Regulation TLR7 NOX1 20532218 3047287 Regulation TLR7 NOX4 20532218 3047288 Regulation TLR7 NPY4R 24586659 2925967 Regulation TLR7 NRAS 23565202 2777234 Regulation TLR7 PAF1 20976181 2479289 Regulation TLR7 PARP1 25118589 1944208 Regulation TLR7 PDC 22414065 398545 Regulation TLR7 PDE4B 21288894 1190554 Regulation TLR7 PELI1 23603814 1962969 Regulation TLR7 PELI1 23603814 1963011 Regulation TLR7 PELI1 23603814 1963012 Regulation TLR7 PHKA2 18947379 111794 Regulation TLR7 PIK3CA 20953381 1748516 Regulation TLR7 PIK3CA 20953381 1748517 Regulation TLR7 PIK3CA 21738617 2532913 Regulation TLR7 PIK3CA 21738617 2533051 Regulation TLR7 PIK3CA 22570785 1688449 Regulation TLR7 PIK3CA 22570785 1688494 Regulation TLR7 PIK3CA 22606294 2642988 Regulation TLR7 PIK3CA 24740015 2954294 Regulation TLR7 PIK3CA 24936377 212477 Regulation TLR7 PIK3CA 24936377 212517 Regulation TLR7 PIK3CA 25228903 914135 Regulation TLR7 PIK3R1 20953381 1748518 Regulation TLR7 PIK3R1 20953381 1748519 Regulation TLR7 PIK3R1 21738617 2532914 Regulation TLR7 PIK3R1 21738617 2533052 Regulation TLR7 PIK3R1 22570785 1688450 Regulation TLR7 PIK3R1 22570785 1688495 Regulation TLR7 PIK3R1 22606294 2642989 Regulation TLR7 PIK3R1 24740015 2954295 Regulation TLR7 PIK3R1 24936377 212478 Regulation TLR7 PIK3R1 24936377 212518 Regulation TLR7 PIK3R1 25228903 914136 Regulation TLR7 PIKFYVE 24040108 2845740 Regulation TLR7 PIN1 21743479 1955559 Regulation TLR7 PIN1 21743479 1955617 Regulation TLR7 PKD1 22783258 902457 Regulation TLR7 PKD3 22928050 2682010 Regulation TLR7 PLXNA4 21098092 1561969 Regulation TLR7 POT1 25118589 1945044 Regulation TLR7 PRKACB 23405061 2751592 Regulation TLR7 PRKACG 23405061 2751593 Regulation TLR7 PRKAR1A 23405061 2751594 Regulation TLR7 PRKAR1B 23405061 2751595 Regulation TLR7 PRKAR2A 23405061 2751596 Regulation TLR7 PRKAR2B 23405061 2751597 Regulation TLR7 PSEN1 22174891 2582459 Regulation TLR7 PTEN 24856829 222967 Regulation TLR7 PTGS1 23850620 145297 Regulation TLR7 QRICH1 24742067 2114012 Regulation TLR7 QRICH2 24742067 2114013 Regulation TLR7 RAC1 21098092 1561861 Regulation TLR7 RAC2 21098092 1561862 Regulation TLR7 RAC3 21098092 1561863 Regulation TLR7 RAD50 25118589 1944211 Regulation TLR7 RAD50 25118589 1945047 Regulation TLR7 RASGRP1 25118589 1943939 Regulation TLR7 RASGRP3 25118589 1944206 Regulation TLR7 RASGRP3 25118589 1945274 Regulation TLR7 RBPJ 22610140 1957435 Regulation TLR7 RELA 21044333 659719 Regulation TLR7 RELA 21451502 1918322 Regulation TLR7 RICTOR 24740015 2954118 Regulation TLR7 RICTOR 24740015 2954500 Regulation TLR7 RNF216 23109936 968853 Regulation TLR7 SARM1 21850204 1057547 Regulation TLR7 SERPINC1 22577589 507197 Regulation TLR7 SETD2 21516132 12704 Regulation TLR7 SIGIRR 18644972 1551632 Regulation TLR7 SIGIRR 22661952 957381 Regulation TLR7 SIGIRR 23950714 3063590 Regulation TLR7 SIGIRR 23950714 3063591 Regulation TLR7 SIGLEC1 22566885 899388 Regulation TLR7 SIGLEC1 25187624 760948 Regulation TLR7 SIGLEC1 25187624 760949 Regulation TLR7 SIGLEC10 22566885 899390 Regulation TLR7 SIGLEC10 25187624 760955 Regulation TLR7 SIGLEC10 25187624 760956 Regulation TLR7 SIGLEC10 25187624 760957 Regulation TLR7 SIGLEC11 22566885 899391 Regulation TLR7 SIGLEC11 25187624 760958 Regulation TLR7 SIGLEC11 25187624 760959 Regulation TLR7 SIGLEC11 25187624 760960 Regulation TLR7 SIGLEC12 22566885 899389 Regulation TLR7 SIGLEC12 25187624 760952 Regulation TLR7 SIGLEC12 25187624 760953 Regulation TLR7 SIGLEC12 25187624 760954 Regulation TLR7 SIGLEC14 22566885 899395 Regulation TLR7 SIGLEC14 25187624 760967 Regulation TLR7 SIGLEC14 25187624 760968 Regulation TLR7 SIGLEC14 25187624 760969 Regulation TLR7 SIGLEC15 22566885 899394 Regulation TLR7 SIGLEC15 25187624 760964 Regulation TLR7 SIGLEC15 25187624 760965 Regulation TLR7 SIGLEC15 25187624 760966 Regulation TLR7 SIGLEC16 22566885 899393 Regulation TLR7 SIGLEC16 25187624 760961 Regulation TLR7 SIGLEC16 25187624 760962 Regulation TLR7 SIGLEC16 25187624 760963 Regulation TLR7 SIGLEC5 22566885 899383 Regulation TLR7 SIGLEC5 25187624 760938 Regulation TLR7 SIGLEC5 25187624 760939 Regulation TLR7 SIGLEC6 22566885 899384 Regulation TLR7 SIGLEC6 25187624 760940 Regulation TLR7 SIGLEC6 25187624 760941 Regulation TLR7 SIGLEC7 22566885 899385 Regulation TLR7 SIGLEC7 25187624 760942 Regulation TLR7 SIGLEC7 25187624 760943 Regulation TLR7 SIGLEC8 22566885 899386 Regulation TLR7 SIGLEC8 25187624 760944 Regulation TLR7 SIGLEC8 25187624 760945 Regulation TLR7 SIGLEC9 22566885 899387 Regulation TLR7 SIGLEC9 25187624 760946 Regulation TLR7 SIGLEC9 25187624 760947 Regulation TLR7 SOCS1 16381597 2368687 Regulation TLR7 SOCS1 19300567 2011637 Regulation TLR7 SOCS1 20862390 979495 Regulation TLR7 SOCS1 20862390 979551 Regulation TLR7 SOCS1 20862390 979597 Regulation TLR7 SOCS1 20862390 979654 Regulation TLR7 SOCS1 21789039 979934 Regulation TLR7 SOCS1 22727118 1663636 Regulation TLR7 SOCS1 24757565 1831889 Regulation TLR7 SOCS2 19779605 2427242 Regulation TLR7 SOCS3 20862390 979496 Regulation TLR7 SOCS3 24069550 1706694 Regulation TLR7 SOCS3 25120543 913746 Regulation TLR7 SPESP1 21943110 2231287 Regulation TLR7 ST2 22661952 957380 Regulation TLR7 ST2 23483993 2764960 Regulation TLR7 STAT6 24489947 2917077 Regulation TLR7 STAT6 24489947 2917078 Regulation TLR7 SULT2A1 21203748 1146732 Regulation TLR7 SYK 18947379 111792 Regulation TLR7 SYK 24286216 130809 Regulation TLR7 SYK 24286216 130842 Regulation TLR7 TAB2 22661952 957461 Regulation TLR7 TAB2 23799152 2807361 Regulation TLR7 TANK 21625535 3051907 Regulation TLR7 TCEA1 22174696 2328021 Regulation TLR7 TCF12 23320062 2739407 Regulation TLR7 TCF15 23320062 2739408 Regulation TLR7 TCF19 23320062 2739409 Regulation TLR7 TCF20 23320062 2739410 Regulation TLR7 TCF21 23320062 2739411 Regulation TLR7 TCF23 23320062 2739415 Regulation TLR7 TCF24 23320062 2739417 Regulation TLR7 TCF25 23320062 2739416 Regulation TLR7 TCF3 23320062 2739412 Regulation TLR7 TCF4 23320062 2739413 Regulation TLR7 TCF7 23320062 2739414 Regulation TLR7 TDGF1P3 23133361 2297644 Regulation TLR7 TERF1 25118589 1945041 Regulation TLR7 TERF2 25118589 1944204 Regulation TLR7 TERF2 25118589 1945042 Regulation TLR7 TERF2IP 25118589 1944207 Regulation TLR7 TERF2IP 25118589 1945045 Regulation TLR7 TFAP4 23426999 748726 Regulation TLR7 THEMIS2 20644716 2455959 Regulation TLR7 TINF2 25118589 1945043 Regulation TLR7 TIRAP 25514371 3224571 Regulation TLR7 TLR2 23840549 2815168 Regulation TLR7 TLR4 21152080 2486077 Regulation TLR7 TLR4 22916010 3059138 Regulation TLR7 TLR4 23429360 838572 Regulation TLR7 TLR4 25187624 760950 Regulation TLR7 TLR4 25187624 760951 Regulation TLR7 TLR8 23085951 596482 Regulation TLR7 TLR8 23281837 127643 Regulation TLR7 TLR9 19386086 242416 Regulation TLR7 TLR9 23189270 863864 Regulation TLR7 TLR9 23396449 2085549 Regulation TLR7 TMEM100 23429360 837668 Regulation TLR7 TMEM101 23429360 837734 Regulation TLR7 TMEM102 23429360 837697 Regulation TLR7 TMEM104 23429360 837677 Regulation TLR7 TMEM105 23429360 837699 Regulation TLR7 TMEM107 23429360 837714 Regulation TLR7 TMEM108 23429360 837727 Regulation TLR7 TMEM109 23429360 837736 Regulation TLR7 TMEM11 23429360 837620 Regulation TLR7 TMEM110 23429360 837748 Regulation TLR7 TMEM114 23429360 837762 Regulation TLR7 TMEM115 23429360 837742 Regulation TLR7 TMEM116 23429360 837648 Regulation TLR7 TMEM117 23429360 837656 Regulation TLR7 TMEM119 23429360 837708 Regulation TLR7 TMEM121 23429360 837630 Regulation TLR7 TMEM123 23429360 837744 Regulation TLR7 TMEM125 23429360 837722 Regulation TLR7 TMEM127 23429360 837678 Regulation TLR7 TMEM128 23429360 837719 Regulation TLR7 TMEM129 23429360 837651 Regulation TLR7 TMEM130 23429360 837659 Regulation TLR7 TMEM131 23429360 837746 Regulation TLR7 TMEM133 23429360 837642 Regulation TLR7 TMEM134 23429360 837681 Regulation TLR7 TMEM135 23429360 837682 Regulation TLR7 TMEM136 23429360 837723 Regulation TLR7 TMEM138 23429360 837701 Regulation TLR7 TMEM139 23429360 837639 Regulation TLR7 TMEM140 23429360 837636 Regulation TLR7 TMEM141 23429360 837720 Regulation TLR7 TMEM143 23429360 837666 Regulation TLR7 TMEM144 23429360 837671 Regulation TLR7 TMEM145 23429360 837700 Regulation TLR7 TMEM147 23429360 837747 Regulation TLR7 TMEM154 23429360 837692 Regulation TLR7 TMEM155 23429360 837690 Regulation TLR7 TMEM156 23429360 837686 Regulation TLR7 TMEM158 23429360 837745 Regulation TLR7 TMEM159 23429360 837743 Regulation TLR7 TMEM160 23429360 837679 Regulation TLR7 TMEM163 23429360 837658 Regulation TLR7 TMEM164 23429360 837685 Regulation TLR7 TMEM165 23429360 837750 Regulation TLR7 TMEM168 23429360 837673 Regulation TLR7 TMEM169 23429360 837650 Regulation TLR7 TMEM17 23429360 837696 Regulation TLR7 TMEM171 23429360 837702 Regulation TLR7 TMEM173 23429360 837711 Regulation TLR7 TMEM174 23429360 837717 Regulation TLR7 TMEM175 23429360 837735 Regulation TLR7 TMEM177 23429360 837715 Regulation TLR7 TMEM179 23429360 837627 Regulation TLR7 TMEM18 23429360 837655 Regulation TLR7 TMEM180 23429360 837684 Regulation TLR7 TMEM181 23429360 837631 Regulation TLR7 TMEM182 23429360 837688 Regulation TLR7 TMEM186 23429360 837645 Regulation TLR7 TMEM187 23429360 837615 Regulation TLR7 TMEM189 23429360 837619 Regulation TLR7 TMEM19 23429360 837667 Regulation TLR7 TMEM190 23429360 837741 Regulation TLR7 TMEM192 23429360 837698 Regulation TLR7 TMEM196 23429360 837640 Regulation TLR7 TMEM198 23429360 837763 Regulation TLR7 TMEM199 23429360 837623 Regulation TLR7 TMEM2 23429360 837611 Regulation TLR7 TMEM201 23429360 837765 Regulation TLR7 TMEM202 23429360 837767 Regulation TLR7 TMEM203 23429360 837721 Regulation TLR7 TMEM204 23429360 837616 Regulation TLR7 TMEM205 23429360 837740 Regulation TLR7 TMEM206 23429360 837665 Regulation TLR7 TMEM207 23429360 837764 Regulation TLR7 TMEM208 23429360 837646 Regulation TLR7 TMEM209 23429360 837637 Regulation TLR7 TMEM210 23429360 837770 Regulation TLR7 TMEM211 23429360 837766 Regulation TLR7 TMEM212 23429360 837771 Regulation TLR7 TMEM213 23429360 837703 Regulation TLR7 TMEM214 23429360 837676 Regulation TLR7 TMEM215 23429360 837769 Regulation TLR7 TMEM216 23429360 837647 Regulation TLR7 TMEM217 23429360 837632 Regulation TLR7 TMEM218 23429360 837705 Regulation TLR7 TMEM219 23429360 837653 Regulation TLR7 TMEM220 23429360 837768 Regulation TLR7 TMEM221 23429360 837638 Regulation TLR7 TMEM222 23429360 837657 Regulation TLR7 TMEM223 23429360 837728 Regulation TLR7 TMEM225 23429360 837759 Regulation TLR7 TMEM230 23429360 837618 Regulation TLR7 TMEM231 23429360 837773 Regulation TLR7 TMEM232 23429360 837774 Regulation TLR7 TMEM233 23429360 837772 Regulation TLR7 TMEM234 23429360 837738 Regulation TLR7 TMEM235 23429360 837707 Regulation TLR7 TMEM236 23429360 837641 Regulation TLR7 TMEM237 23429360 837617 Regulation TLR7 TMEM238 23429360 837775 Regulation TLR7 TMEM239 23429360 837776 Regulation TLR7 TMEM240 23429360 837652 Regulation TLR7 TMEM241 23429360 837752 Regulation TLR7 TMEM242 23429360 837622 Regulation TLR7 TMEM243 23429360 837634 Regulation TLR7 TMEM244 23429360 837633 Regulation TLR7 TMEM245 23429360 837614 Regulation TLR7 TMEM246 23429360 837716 Regulation TLR7 TMEM247 23429360 837777 Regulation TLR7 TMEM248 23429360 837661 Regulation TLR7 TMEM249 23429360 837778 Regulation TLR7 TMEM25 23429360 837675 Regulation TLR7 TMEM251 23429360 837629 Regulation TLR7 TMEM252 23429360 837730 Regulation TLR7 TMEM253 23429360 837761 Regulation TLR7 TMEM254 23429360 837672 Regulation TLR7 TMEM256 23429360 837733 Regulation TLR7 TMEM257 23429360 837669 Regulation TLR7 TMEM258 23429360 837610 Regulation TLR7 TMEM259 23429360 837621 Regulation TLR7 TMEM26 23429360 837731 Regulation TLR7 TMEM260 23429360 837628 Regulation TLR7 TMEM261 23429360 837749 Regulation TLR7 TMEM27 23429360 837739 Regulation TLR7 TMEM31 23429360 837732 Regulation TLR7 TMEM33 23429360 837663 Regulation TLR7 TMEM35 23429360 837674 Regulation TLR7 TMEM37 23429360 837624 Regulation TLR7 TMEM40 23429360 837670 Regulation TLR7 TMEM42 23429360 837726 Regulation TLR7 TMEM43 23429360 837729 Regulation TLR7 TMEM44 23429360 837649 Regulation TLR7 TMEM47 23429360 837625 Regulation TLR7 TMEM5 23429360 837613 Regulation TLR7 TMEM51 23429360 837662 Regulation TLR7 TMEM52 23429360 837710 Regulation TLR7 TMEM53 23429360 837683 Regulation TLR7 TMEM54 23429360 837643 Regulation TLR7 TMEM56 23429360 837691 Regulation TLR7 TMEM57 23429360 837664 Regulation TLR7 TMEM59 23429360 837612 Regulation TLR7 TMEM60 23429360 837635 Regulation TLR7 TMEM61 23429360 837704 Regulation TLR7 TMEM62 23429360 837687 Regulation TLR7 TMEM64 23429360 837660 Regulation TLR7 TMEM65 23429360 837654 Regulation TLR7 TMEM66 23429360 837737 Regulation TLR7 TMEM67 23429360 837725 Regulation TLR7 TMEM68 23429360 837693 Regulation TLR7 TMEM69 23429360 837712 Regulation TLR7 TMEM70 23429360 837680 Regulation TLR7 TMEM71 23429360 837694 Regulation TLR7 TMEM72 23429360 837751 Regulation TLR7 TMEM74 23429360 837689 Regulation TLR7 TMEM75 23429360 837753 Regulation TLR7 TMEM78 23429360 837754 Regulation TLR7 TMEM79 23429360 837718 Regulation TLR7 TMEM80 23429360 837706 Regulation TLR7 TMEM81 23429360 837755 Regulation TLR7 TMEM82 23429360 837756 Regulation TLR7 TMEM88 23429360 837757 Regulation TLR7 TMEM89 23429360 837758 Regulation TLR7 TMEM9 23429360 837626 Regulation TLR7 TMEM91 23429360 837760 Regulation TLR7 TMEM92 23429360 837695 Regulation TLR7 TMEM95 23429360 837709 Regulation TLR7 TMEM97 23429360 837713 Regulation TLR7 TMEM98 23429360 837644 Regulation TLR7 TMEM99 23429360 837724 Regulation TLR7 TNFAIP3 18268035 1549114 Regulation TLR7 TNFAIP3 18268035 1549248 Regulation TLR7 TNFAIP3 18268035 1549280 Regulation TLR7 TNFAIP3 21750679 2325172 Regulation TLR7 TNIP1 21750679 2325173 Regulation TLR7 TOLLIP 24459463 910877 Regulation TLR7 TP53 21483755 2323155 Regulation TLR7 TRAF1 24058413 2847316 Regulation TLR7 TRAF3 23758787 1649525 Regulation TLR7 TRAF3 25010048 2987736 Regulation TLR7 TRAF6 19479062 2417712 Regulation TLR7 TRAF6 20497537 362666 Regulation TLR7 TRAF6 20929569 403296 Regulation TLR7 TRAF6 21188194 139564 Regulation TLR7 TRAF6 21639951 122807 Regulation TLR7 TRAF6 23799152 2807358 Regulation TLR7 TRAM1 14517278 1529015 Regulation TLR7 TRAM1 23078795 1617339 Regulation TLR7 TRAM1 25514371 3224572 Regulation TLR7 TRAM2 14517278 1529014 Regulation TLR7 TRAM2 23078795 1617338 Regulation TLR7 TRAM2 25514371 3224570 Regulation TLR7 TRIM21 22479513 2615646 Regulation TLR7 TRIP10 22945920 1569003 Regulation TLR7 TRIP10 22945920 1569221 Regulation TLR7 TRIP11 22945920 1569004 Regulation TLR7 TRIP11 22945920 1569222 Regulation TLR7 TRIP12 22945920 1569005 Regulation TLR7 TRIP12 22945920 1569223 Regulation TLR7 TRIP13 22945920 1569006 Regulation TLR7 TRIP13 22945920 1569224 Regulation TLR7 TRIP4 22945920 1569007 Regulation TLR7 TRIP4 22945920 1569225 Regulation TLR7 TRIP6 22945920 1569008 Regulation TLR7 TRIP6 22945920 1569226 Regulation TLR7 TSLP 24335833 1736612 Regulation TLR7 UBE2V1 23799152 2807359 Regulation TLR7 UNC93B1 17452530 1339611 Regulation TLR7 UNC93B1 17452530 1339900 Regulation TLR7 UNC93B1 23426999 748727 Regulation TLR7 UNC93B1 23426999 748803 Regulation TLR7 UNC93B1 23426999 748804 Regulation TLR7 UNC93B1 25309543 914377 Regulation TLR7 UNC93B1 25309543 914383 Regulation TLR7 UNC93B2 17452530 1339612 Regulation TLR7 UNC93B2 17452530 1339901 Regulation TLR7 UNC93B3 17452530 1339613 Regulation TLR7 UNC93B3 17452530 1339902 Regulation TLR7 UNC93B4 17452530 1339614 Regulation TLR7 UNC93B4 17452530 1339903 Regulation TLR7 UNC93B5 17452530 1339615 Regulation TLR7 UNC93B5 17452530 1339904 Regulation TLR7 UNC93B6 17452530 1339616 Regulation TLR7 UNC93B6 17452530 1339905 Regulation TLR7 UNC93B7 17452530 1339617 Regulation TLR7 UNC93B7 17452530 1339906 Regulation TLR7 UNC93B8 17452530 1339618 Regulation TLR7 UNC93B8 17452530 1339907 Regulation TLR7 WDR61 20976181 2479290 Regulation TLR7 WNK1 22570745 1024111 Regulation TLR7 WNT1 23832647 1022292 Regulation TLR7 WNT11 23832647 1022293 Regulation TLR7 WNT16 23832647 1022298 Regulation TLR7 WNT2 23832647 1022294 Regulation TLR7 WNT3 23832647 1022295 Regulation TLR7 WNT4 23832647 1022296 Regulation TLR7 WNT6 23832647 1022297 Regulation TLR7 WWP1 23799152 2807360 Regulation TLR7 XRCC5 25118589 1944205 Regulation TLR7 XRCC6 25118589 1944209 Regulation TLR7 YME1L1 21483755 2323156 Regulation TLR8 CD14 20236452 659512 Regulation TLR8 CD14 21789185 2537994 Regulation TLR8 CD14 24672516 926402 Regulation TLR8 CD14 25474158 2373497 Regulation TLR8 CD22 22566885 899405 Regulation TLR8 EPHB2 22783258 902350 Regulation TLR8 EPHB2 22783258 902351 Regulation TLR8 EPHB2 22783258 902381 Regulation TLR8 EPHB2 23405061 2751484 Regulation TLR8 EPHB2 24927726 1684643 Regulation TLR8 MX2 22043290 2566016 Regulation TLR8 PDE4B 21288894 1190555 Regulation TLR8 SARM1 21850204 1057548 Regulation TLR8 TLR7 17893200 1547147 Regulation TLR8 TMEM100 23429360 837838 Regulation TLR8 TMEM156 23429360 837856 Regulation TLR8 TMEM211 23429360 837936 Regulation TLR8 TMEM213 23429360 837873 Regulation TLR9 ADRB2 23724117 2799028 Regulation TLR9 CD14 20236452 659513 Regulation TLR9 CD14 21789185 2537995 Regulation TLR9 CD14 24672516 926403 Regulation TLR9 CD14 25474158 2373499 Regulation TLR9 CD22 22566885 899418 Regulation TLR9 EPHB2 22783258 902353 Regulation TLR9 EPHB2 22783258 902354 Regulation TLR9 EPHB2 22783258 902383 Regulation TLR9 EPHB2 23405061 2751499 Regulation TLR9 EPHB2 24927726 1684645 Regulation TLR9 MX2 22043290 2566017 Regulation TLR9 PDE4B 21288894 1190556 Regulation TLR9 SARM1 21850204 1057549 Regulation TLR9 TLR7 19386086 242417 Regulation TLR9 TLR7 20051129 3110197 Regulation TLR9 TLR7 20051129 3110239 Regulation TLR9 TLR7 20182644 1213859 Regulation TLR9 TLR7 21743479 1955561 Regulation TLR9 TLR7 21743479 1955571 Regulation TLR9 TLR7 22919688 863623 Regulation TLR9 TLR7 24489947 2917039 Regulation TLR9 TMEM100 23429360 838008 Regulation TLR9 TMEM156 23429360 838026 Regulation TLR9 TMEM211 23429360 838106 Regulation TLR9 TMEM213 23429360 838043 Regulation TLR9 TNF 23650544 2788936 Regulation TLR9 TP63 16365150 1538971 Regulation TMC8 TNF 23429285 560012 Regulation TMED7 EGLN3 22087251 2570786 Regulation TMED7 FOXO1 23630664 943090 Regulation TMED7 ID1 23342268 491938 Regulation TMED7 IFI27 20200561 1719459 Regulation TMED7 UCA1 24457952 571313 Regulation TMEM100 ANKH 20200976 1237420 Regulation TMEM100 CA2 22645520 873369 Regulation TMEM100 GDF2 24670474 1125661 Regulation TMEM100 MAMSTR 22570537 489601 Regulation TMEM100 MYLIP 24098708 2859345 Regulation TMEM100 NEDD4L 24961812 1882975 Regulation TMEM100 PTCH1 24393163 1871286 Regulation TMEM100 SLN 24255707 2881899 Regulation TMEM100 WNT1 19424478 670739 Regulation TMEM100 WNT11 19424478 670740 Regulation TMEM100 WNT16 19424478 670745 Regulation TMEM100 WNT2 19424478 670741 Regulation TMEM100 WNT3 19424478 670742 Regulation TMEM100 WNT4 19424478 670743 Regulation TMEM100 WNT6 19424478 670744 Regulation TMEM156 ANKH 20200976 1237438 Regulation TMEM156 CA2 22645520 873387 Regulation TMEM156 MAMSTR 22570537 489619 Regulation TMEM156 MYLIP 24098708 2859363 Regulation TMEM156 NEDD4L 24961812 1882993 Regulation TMEM156 PTCH1 24393163 1871304 Regulation TMEM156 SLN 24255707 2881917 Regulation TMEM156 WNT1 19424478 670865 Regulation TMEM156 WNT11 19424478 670866 Regulation TMEM156 WNT16 19424478 670871 Regulation TMEM156 WNT2 19424478 670867 Regulation TMEM156 WNT3 19424478 670868 Regulation TMEM156 WNT4 19424478 670869 Regulation TMEM156 WNT6 19424478 670870 Regulation TMEM182 TNF 24903457 361411 Regulation TMEM211 ANKH 20200976 1237518 Regulation TMEM211 CA2 22645520 873467 Regulation TMEM211 MAMSTR 22570537 489868 Regulation TMEM211 MYLIP 24098708 2859445 Regulation TMEM211 NEDD4L 24961812 1883073 Regulation TMEM211 PTCH1 24393163 1871384 Regulation TMEM211 SLN 24255707 2881997 Regulation TMEM211 WNT1 19424478 671425 Regulation TMEM211 WNT11 19424478 671426 Regulation TMEM211 WNT16 19424478 671431 Regulation TMEM211 WNT2 19424478 671427 Regulation TMEM211 WNT3 19424478 671428 Regulation TMEM211 WNT4 19424478 671429 Regulation TMEM211 WNT6 19424478 671430 Regulation TMEM213 ANKH 20200976 1237455 Regulation TMEM213 CA2 22645520 873404 Regulation TMEM213 MAMSTR 22570537 489805 Regulation TMEM213 MYLIP 24098708 2859381 Regulation TMEM213 NEDD4L 24961812 1883010 Regulation TMEM213 PTCH1 24393163 1871321 Regulation TMEM213 SLN 24255707 2881934 Regulation TMEM213 WNT1 19424478 670984 Regulation TMEM213 WNT11 19424478 670985 Regulation TMEM213 WNT16 19424478 670990 Regulation TMEM213 WNT2 19424478 670986 Regulation TMEM213 WNT3 19424478 670987 Regulation TMEM213 WNT4 19424478 670988 Regulation TMEM213 WNT6 19424478 670989 Regulation TMEM45A SETD2 22954140 266234 Regulation TMOD1 CA2 19255776 2242661 Regulation TMOD1 CA2 19629180 2421844 Regulation TMOD1 CA2 20584889 1609743 Regulation TMOD1 CA2 22500102 1223947 Regulation TMOD1 CA2 22737252 2655722 Regulation TMOD1 CA2 23227172 2725605 Regulation TMOD1 CA2 4621650 1429207 Regulation TMOD1 CALD1 8163552 1445384 Regulation TMOD1 CALD1 8408215 1448258 Regulation TMOD1 GATA4 21702924 508570 Regulation TMOD1 MYBPC1 22545180 143536 Regulation TMOD1 MYBPC2 22545180 143537 Regulation TMOD1 MYBPC3 22545180 143538 Regulation TMOD1 MYO10 25520664 967228 Regulation TMOD1 MYO16 25520664 967227 Regulation TMOD1 MYO19 25520664 967226 Regulation TMOD1 MYO6 25520664 967229 Regulation TMOD1 NEB 16157704 1323979 Regulation TMOD1 NEB 22013379 1222799 Regulation TMOD1 NEB 22470472 2614264 Regulation TMOD1 NEBL 22375125 956450 Regulation TMOD1 PRKACB 15738048 1608092 Regulation TMOD1 PRKACB 19433622 1609383 Regulation TMOD1 PRKACG 15738048 1608093 Regulation TMOD1 PRKACG 19433622 1609384 Regulation TMOD1 PRKAR1A 15738048 1608094 Regulation TMOD1 PRKAR1A 19433622 1609385 Regulation TMOD1 PRKAR1B 15738048 1608095 Regulation TMOD1 PRKAR1B 19433622 1609386 Regulation TMOD1 PRKAR2A 15738048 1608096 Regulation TMOD1 PRKAR2A 19433622 1609387 Regulation TMOD1 PRKAR2B 15738048 1608097 Regulation TMOD1 PRKAR2B 19433622 1609388 Regulation TMOD1 RHO 24130935 204627 Regulation TMOD1 TMOD1 12975349 1297085 Regulation TMOD1 TMOD1 22013379 1222823 Regulation TMOD1 TPM1 8163552 1445380 Regulation TMOD1 TPM1 8408215 1448254 Regulation TMOD1 TPM2 8163552 1445381 Regulation TMOD1 TPM2 8408215 1448255 Regulation TMOD1 TPM3 8163552 1445382 Regulation TMOD1 TPM3 8408215 1448256 Regulation TMOD1 TPM4 8163552 1445383 Regulation TMOD1 TPM4 8408215 1448257 Regulation TMPRSS4 KAT5 23821596 992836 Regulation TMPRSS4 MORF4L1 23821596 992835 Regulation TMPRSS4 RPS27 24934155 1419793 Regulation TMPRSS5 PCDH8 21529371 1996814 Regulation TNC STAT4 21205293 3111879 Regulation TNC TNF 21205293 3111875 Regulation TNC TNF 21205293 3111883 Regulation TNF ABCC1 24086787 2372190 Regulation TNF ACAN 22594821 125882 Regulation TNF ACKR3 25084358 2994449 Regulation TNF ACPP 23577176 2778507 Regulation TNF ACR 21437062 629871 Regulation TNF ADAM11 22953039 2233618 Regulation TNF ADAM17 21980496 2560999 Regulation TNF ADAM17 22389670 2607909 Regulation TNF ADAM17 24223177 2876612 Regulation TNF ADAM17 25045210 1760166 Regulation TNF ADIPOQ 20156719 809179 Regulation TNF ADM 21477302 3112021 Regulation TNF ADO 21675943 680455 Regulation TNF ADO 23897810 1207980 Regulation TNF AGA 21317295 717925 Regulation TNF AGA 21317295 717934 Regulation TNF AGA 21317295 717942 Regulation TNF AGAP3 23493728 1624163 Regulation TNF AGO2 21124909 2484560 Regulation TNF AGO2 23493408 1623979 Regulation TNF AHR 12204817 791186 Regulation TNF AHR 22110376 1058211 Regulation TNF AHR 22110376 1058213 Regulation TNF AHR 22110376 1058215 Regulation TNF AHR 23099484 795108 Regulation TNF AHSA1 20644716 2455939 Regulation TNF AHSA1 21314908 3209836 Regulation TNF AHSA1 22829768 3058197 Regulation TNF AHSA1 23549267 1104855 Regulation TNF AHSA1 24205379 2876327 Regulation TNF AHSA1 24963482 193017 Regulation TNF AHSG 18335040 2386916 Regulation TNF AHSG 23577176 2778506 Regulation TNF AIMP2 21483803 2323370 Regulation TNF AKT1 10974038 1516967 Regulation TNF AKT1 10974038 1516968 Regulation TNF AKT1 10974038 1517033 Regulation TNF AKT1 17208518 3203985 Regulation TNF AKT1 21483870 2512555 Regulation TNF AKT1 21949832 2556785 Regulation TNF AKT1 22973314 1068894 Regulation TNF AKT1 23731754 1627005 Regulation TNF AKT1 24669186 742952 Regulation TNF AKT2 10974038 1516969 Regulation TNF AKT2 10974038 1516970 Regulation TNF AKT2 10974038 1517034 Regulation TNF AKT2 17208518 3203986 Regulation TNF AKT2 21483870 2512556 Regulation TNF AKT2 21949832 2556786 Regulation TNF AKT2 22973314 1068895 Regulation TNF AKT2 23731754 1627006 Regulation TNF AKT2 24669186 742953 Regulation TNF AKT3 10974038 1516971 Regulation TNF AKT3 10974038 1516972 Regulation TNF AKT3 10974038 1517035 Regulation TNF AKT3 17208518 3203987 Regulation TNF AKT3 21483870 2512557 Regulation TNF AKT3 21949832 2556787 Regulation TNF AKT3 22973314 1068896 Regulation TNF AKT3 23731754 1627007 Regulation TNF AKT3 24669186 742954 Regulation TNF ALB 21042558 1912094 Regulation TNF ALB 21042558 1912098 Regulation TNF ALB 21603190 22870 Regulation TNF ALOX5AP 11877481 1523107 Regulation TNF ALPI 23533546 656745 Regulation TNF ANGPT2 19416526 659188 Regulation TNF ANXA6 11879539 98575 Regulation TNF AP5B1 23094196 1082715 Regulation TNF APC 9053444 1600138 Regulation TNF APOA1 12110136 99149 Regulation TNF APOB 12366867 350311 Regulation TNF APOB 12366867 350315 Regulation TNF APOB 23983406 1754633 Regulation TNF APOB 25172490 1621055 Regulation TNF ARAF 7790814 1592137 Regulation TNF ARG1 23760286 1709450 Regulation TNF ARG1 23760286 1709451 Regulation TNF ARG1 25501750 3033700 Regulation TNF ARG1 3260938 1580640 Regulation TNF ARG1 3260938 1580662 Regulation TNF ARG2 23760286 1709452 Regulation TNF ARG2 23760286 1709453 Regulation TNF ARG2 25501750 3033701 Regulation TNF ARG2 3260938 1580641 Regulation TNF ARG2 3260938 1580663 Regulation TNF ARSA 18475455 1743811 Regulation TNF ASAP2 23238132 651903 Regulation TNF ATF2 12361922 791234 Regulation TNF ATF2 12361922 791236 Regulation TNF ATF2 20507572 353444 Regulation TNF ATF3 24062788 822842 Regulation TNF ATL1 21831303 1659250 Regulation TNF ATL2 21831303 1659251 Regulation TNF ATL3 21831303 1659252 Regulation TNF ATP8A2 18955281 811112 Regulation TNF ATR 22768051 2659587 Regulation TNF BCL3 24130828 2867268 Regulation TNF BCL3 24130828 2867269 Regulation TNF BCL3 24130828 2867271 Regulation TNF BIRC2 22934195 1153698 Regulation TNF BIRC2 23028454 2690660 Regulation TNF BIRC3 23028454 2690661 Regulation TNF BMP2 24820069 453989 Regulation TNF BRAF 21871121 1659637 Regulation TNF BRD1 22189182 1230016 Regulation TNF BRD1 22189182 1230022 Regulation TNF BTK 21611196 2523835 Regulation TNF BTK 21611196 2523851 Regulation TNF BTK 21611196 2523855 Regulation TNF BTK 21611196 2523862 Regulation TNF BTK 22592745 694254 Regulation TNF BTK 25170774 3003928 Regulation TNF BTK 9547335 1602611 Regulation TNF C3 21855168 1041349 Regulation TNF C3 22069473 2569039 Regulation TNF C4A 24789665 1886409 Regulation TNF C5 2165128 1564028 Regulation TNF C5 3260938 1580639 Regulation TNF C5 3260938 1580648 Regulation TNF C5 3260938 1580661 Regulation TNF C5 3260938 1580671 Regulation TNF C5 3260938 1580673 Regulation TNF C5 9271590 1601596 Regulation TNF C9orf3 23985898 1730110 Regulation TNF CA2 18404427 3087196 Regulation TNF CA2 22666474 2648191 Regulation TNF CA2 23420671 906053 Regulation TNF CA2 24885636 273452 Regulation TNF CA2 2536067 1577279 Regulation TNF CA7 23193206 729942 Regulation TNF CALM3 18472853 1742281 Regulation TNF CARD9 19139169 1553581 Regulation TNF CARD9 21283787 3051081 Regulation TNF CASP1 11381085 1270278 Regulation TNF CASP1 19740426 659282 Regulation TNF CASP1 24454930 2910418 Regulation TNF CASP10 11381085 1270279 Regulation TNF CASP10 19740426 659283 Regulation TNF CASP12 11381085 1270289 Regulation TNF CASP12 19740426 659293 Regulation TNF CASP14 11381085 1270280 Regulation TNF CASP14 19740426 659284 Regulation TNF CASP16 11381085 1270291 Regulation TNF CASP16 19740426 659294 Regulation TNF CASP2 11381085 1270281 Regulation TNF CASP2 19740426 659285 Regulation TNF CASP3 11381085 1270282 Regulation TNF CASP3 19740426 659286 Regulation TNF CASP3 21311098 2174899 Regulation TNF CASP3 22471589 1230541 Regulation TNF CASP3 22471589 1230543 Regulation TNF CASP3 23193206 729943 Regulation TNF CASP4 11381085 1270283 Regulation TNF CASP4 19740426 659287 Regulation TNF CASP5 11381085 1270284 Regulation TNF CASP5 19740426 659288 Regulation TNF CASP6 11381085 1270285 Regulation TNF CASP6 19740426 659289 Regulation TNF CASP7 11381085 1270286 Regulation TNF CASP7 19740426 659290 Regulation TNF CASP8 10704075 1736864 Regulation TNF CASP8 11381085 1270287 Regulation TNF CASP8 19740426 659291 Regulation TNF CASP9 11381085 1270288 Regulation TNF CASP9 19740426 659292 Regulation TNF CASP9 21311098 2174900 Regulation TNF CASR 21603229 955311 Regulation TNF CASR 23564188 1879568 Regulation TNF CBR1 19476641 1897215 Regulation TNF CBR1 19476641 1897224 Regulation TNF CCDC88A 23967134 2834585 Regulation TNF CCL2 19936231 2431761 Regulation TNF CCL2 22031820 2565193 Regulation TNF CCL4 24892615 653897 Regulation TNF CCNG1 11581316 1521087 Regulation TNF CCR7 21468000 1905576 Regulation TNF CD14 17242961 810105 Regulation TNF CD14 20419140 2447178 Regulation TNF CD14 23964697 1651390 Regulation TNF CD14 24489448 1757425 Regulation TNF CD14 24489448 1757426 Regulation TNF CD14 24489448 1757427 Regulation TNF CD14 24489448 1757428 Regulation TNF CD14 24489448 1757440 Regulation TNF CD14 7505800 1588825 Regulation TNF CD160 24516120 1575042 Regulation TNF CD2 25505551 1037374 Regulation TNF CD200R1 22025201 1629416 Regulation TNF CD27 15184507 1532879 Regulation TNF CD274 23056446 2701568 Regulation TNF CD28 15833106 3104976 Regulation TNF CD28 24396625 1150509 Regulation TNF CD28 25041351 2251124 Regulation TNF CD36 19847289 2429178 Regulation TNF CD36 21949655 3053535 Regulation TNF CD36 22292032 2592034 Regulation TNF CD36 24204889 2874763 Regulation TNF CD38 25054074 1083010 Regulation TNF CD4 18477401 1640963 Regulation TNF CD4 21085470 2370884 Regulation TNF CD4 21423609 2508119 Regulation TNF CD4 21556142 2517729 Regulation TNF CD4 21556142 2517751 Regulation TNF CD4 21556142 2517762 Regulation TNF CD4 22003408 2562350 Regulation TNF CD4 23300801 2736007 Regulation TNF CD4 23300801 2736012 Regulation TNF CD4 23300801 2736013 Regulation TNF CD4 23300801 2736025 Regulation TNF CD4 23493728 1624162 Regulation TNF CD4 23774102 1492608 Regulation TNF CD4 23977084 2838332 Regulation TNF CD4 25490675 3033297 Regulation TNF CD40 17296788 1544381 Regulation TNF CD40 18817573 1655567 Regulation TNF CD40LG 14568985 1529378 Regulation TNF CD40LG 23837669 128448 Regulation TNF CD40LG 23970926 638395 Regulation TNF CD40LG 25161698 803829 Regulation TNF CD48 16684368 105993 Regulation TNF CD74 16618371 319022 Regulation TNF CD79A 22451718 1567870 Regulation TNF CD79A 23774102 1492609 Regulation TNF CD8A 17183635 2373592 Regulation TNF CD8A 21483676 2511788 Regulation TNF CD8A 22003411 2562376 Regulation TNF CD8A 23383283 2750085 Regulation TNF CD8A 23774102 1492610 Regulation TNF CD8B 22003411 2562377 Regulation TNF CD8B 23383283 2750086 Regulation TNF CD8B 23774102 1492611 Regulation TNF CD9 20824074 2473609 Regulation TNF CDC73 14580106 3228345 Regulation TNF CEBPA 21314908 3209831 Regulation TNF CEBPA 24381940 186048 Regulation TNF CFLAR 21307398 2174854 Regulation TNF CFLAR 22348197 497094 Regulation TNF CFLAR 25379355 1243452 Regulation TNF CFP 12885154 702333 Regulation TNF CFP 22132075 2573987 Regulation TNF CHM 25053922 1627937 Regulation TNF CHUK 16177180 2017696 Regulation TNF CHUK 25762184 1623433 Regulation TNF CHUK 9841930 1604800 Regulation TNF CLEC7A 21603213 632769 Regulation TNF CLEC7A 24109480 909109 Regulation TNF CLIP3 22297296 554136 Regulation TNF CLU 25342887 743390 Regulation TNF CNOT11 23136361 1613561 Regulation TNF CNR2 22716035 1663562 Regulation TNF CNTN2 21345194 1504911 Regulation TNF CNTN2 21345194 1504912 Regulation TNF CNTN2 21345194 1504913 Regulation TNF COQ2 25326018 1148467 Regulation TNF COQ2 25326018 1148498 Regulation TNF COQ3 25326018 1148463 Regulation TNF COQ3 25326018 1148494 Regulation TNF COQ4 25326018 1148464 Regulation TNF COQ4 25326018 1148495 Regulation TNF COQ5 25326018 1148469 Regulation TNF COQ5 25326018 1148500 Regulation TNF COQ6 25326018 1148465 Regulation TNF COQ6 25326018 1148496 Regulation TNF COQ7 25326018 1148466 Regulation TNF COQ7 25326018 1148497 Regulation TNF COQ9 25326018 1148468 Regulation TNF COQ9 25326018 1148499 Regulation TNF CORD1 17485512 1545803 Regulation TNF CPN1 25253920 1762442 Regulation TNF CPP 23577176 2778508 Regulation TNF CPZ 2033366 1557963 Regulation TNF CPZ 23565187 2777074 Regulation TNF CPZ 24349012 2896586 Regulation TNF CREB1 24225056 275975 Regulation TNF CREB3 24225056 275976 Regulation TNF CREB5 24225056 275974 Regulation TNF CRK 19566962 3109713 Regulation TNF CRK 20644716 2455972 Regulation TNF CRK 21629204 1734973 Regulation TNF CRK 23226236 2723840 Regulation TNF CRP 19533192 3163511 Regulation TNF CRP 22216303 2585488 Regulation TNF CRY1 23335987 2741207 Regulation TNF CRY2 23335987 2741208 Regulation TNF CSE 21738617 2532908 Regulation TNF CSE 22359478 1714078 Regulation TNF CSF1R 20181277 118371 Regulation TNF CSF1R 20181277 118374 Regulation TNF CSF1R 20181277 118378 Regulation TNF CSF2 1512539 1532289 Regulation TNF CSF2 18947379 111833 Regulation TNF CSF2 24564340 357490 Regulation TNF CSF2 3049913 1579817 Regulation TNF CSF2 8006603 1593768 Regulation TNF CSK 21931706 2554189 Regulation TNF CSK 24349012 2896570 Regulation TNF CSK 24349012 2896613 Regulation TNF CSK 24349012 2896614 Regulation TNF CSK 24349012 2896629 Regulation TNF CSRP1 24505395 2920779 Regulation TNF CTR9 14580106 3228346 Regulation TNF CTSB 11381085 1270290 Regulation TNF CTSB 25526565 1136156 Regulation TNF CUX1 23805228 2807923 Regulation TNF CUX1 23805228 2807924 Regulation TNF CX3CL1 22093090 1892518 Regulation TNF CXCL10 22132075 2573984 Regulation TNF CXCL12 18371213 110356 Regulation TNF CXCR4 16109172 3115869 Regulation TNF CYTIP 24945497 2981328 Regulation TNF DAP 10402466 1248032 Regulation TNF DBT 18958157 2399410 Regulation TNF DEFB103B 21809339 808386 Regulation TNF DEFB103B 21809339 808418 Regulation TNF DNAJC5 21556142 2517728 Regulation TNF DNAJC5 21556142 2517761 Regulation TNF DNAJC5 23300801 2736011 Regulation TNF DOK3 22761938 2659388 Regulation TNF DPP4 11027426 417845 Regulation TNF DPP4 23805228 2807965 Regulation TNF DUSP1 20017901 353378 Regulation TNF DUSP10 24842373 1576397 Regulation TNF DUSP4 21085614 3050044 Regulation TNF DYNLRB1 22808176 2664998 Regulation TNF DYNLRB1 23638011 2786986 Regulation TNF DYNLRB1 23638011 2786990 Regulation TNF ECM1 24519465 2243679 Regulation TNF ECM1 8666673 1452091 Regulation TNF ECM2 24519465 2243680 Regulation TNF ECM2 8666673 1452092 Regulation TNF EDN1 23577221 2225758 Regulation TNF EEF1A2 22583375 3112973 Regulation TNF EGR1 19765320 1227436 Regulation TNF EGR1 20087343 434322 Regulation TNF EHMT1 20953406 979670 Regulation TNF EIF1 20939898 353689 Regulation TNF EIF2AK2 14979937 100125 Regulation TNF EIF2AK2 14979937 100183 Regulation TNF EIF2AK2 21699726 1658626 Regulation TNF EIF2AK2 22359543 2597627 Regulation TNF ELAVL1 20459669 3118924 Regulation TNF ELAVL1 23028373 2338516 Regulation TNF ENO3 24192345 295261 Regulation TNF EPAS1 24520300 2167674 Regulation TNF EPHB2 15575964 1844343 Regulation TNF EPHB2 20644716 2455940 Regulation TNF EPHB2 20644716 2455973 Regulation TNF EPHB2 21317295 717902 Regulation TNF EPHB2 21317295 717935 Regulation TNF EPHB2 21789185 2538094 Regulation TNF EPHB2 22384111 2605793 Regulation TNF EPHB2 22384111 2605794 Regulation TNF EPHB2 24191131 1754979 Regulation TNF EPHB2 24304472 1482134 Regulation TNF EPO 23956505 1754516 Regulation TNF EPX 22353555 166518 Regulation TNF ERP27 24385881 3155744 Regulation TNF ERP29 24385881 3155742 Regulation TNF ERP44 24385881 3155743 Regulation TNF ESAT 22132075 2573985 Regulation TNF ESAT 24260295 2883664 Regulation TNF F2R 25147434 1761155 Regulation TNF F2RL1 21072196 2481372 Regulation TNF F2RL1 22175012 1686821 Regulation TNF F2RL1 22175012 1686823 Regulation TNF F2RL3 21593984 1047276 Regulation TNF FAS 12177809 422002 Regulation TNF FAS 25028665 194805 Regulation TNF FASLG 20664736 1709771 Regulation TNF FASN 24349275 2897330 Regulation TNF FCER2 21526166 2513808 Regulation TNF FCGR3A 22184119 1200868 Regulation TNF FGB PMC3332409 134760 Regulation TNF FGFR3 23936328 2829943 Regulation TNF FGFR3 24733966 1758184 Regulation TNF FGFR3 24733966 1758185 Regulation TNF FGL2 21750671 3052235 Regulation TNF FLOT2 18475487 1744010 Regulation TNF FLOT2 18475487 1744011 Regulation TNF FLOT2 18475487 1744012 Regulation TNF FLOT2 18475487 1744014 Regulation TNF FLOT2 18475742 1746302 Regulation TNF FLOT2 18475742 1746305 Regulation TNF FLT3LG 23349985 2744346 Regulation TNF FOS 23173923 381159 Regulation TNF FOS 24465697 2911458 Regulation TNF FOXO1 20300563 1910606 Regulation TNF FOXO3 19363483 1952347 Regulation TNF FSTL1 20404927 2446599 Regulation TNF FXR1 24069363 2853085 Regulation TNF FXYD1 24367694 2900581 Regulation TNF FYB 22672517 532755 Regulation TNF GAPDH 24902773 3142154 Regulation TNF GGA1 18193105 1489138 Regulation TNF GGA2 18193105 1489136 Regulation TNF GGA3 18193105 1489137 Regulation TNF GIF 23798880 2248449 Regulation TNF GLA 23393601 2751379 Regulation TNF GLI3 23093861 1225240 Regulation TNF GOT2 15770048 1739931 Regulation TNF GP2 10360649 414280 Regulation TNF GP5 10360649 414281 Regulation TNF GP6 10360649 414279 Regulation TNF GP9 10360649 414282 Regulation TNF GPI 18475691 1745396 Regulation TNF GPI 18475691 1745397 Regulation TNF GPI 22518279 1079953 Regulation TNF GPI 22558080 2624252 Regulation TNF GPR65 19479052 2417572 Regulation TNF GPR65 19479052 2417576 Regulation TNF GPR68 19479052 2417573 Regulation TNF GPR68 19479052 2417577 Regulation TNF GRAP2 20230629 402472 Regulation TNF GRAP2 21317295 717936 Regulation TNF GRAP2 23227067 3204585 Regulation TNF GRAP2 23587438 1666544 Regulation TNF GRAP2 24916922 1668192 Regulation TNF GRB10 25371727 845336 Regulation TNF GRB10 25371727 845337 Regulation TNF GRB14 25371727 845338 Regulation TNF GRB14 25371727 845339 Regulation TNF GRB2 25371727 845340 Regulation TNF GRB2 25371727 845341 Regulation TNF GRB7 25371727 845342 Regulation TNF GRB7 25371727 845343 Regulation TNF GTS 21843370 1659410 Regulation TNF HAMP 23505235 91339 Regulation TNF HAVCR2 23144609 3059993 Regulation TNF HCK 25332099 607570 Regulation TNF HCL1 15469594 658538 Regulation TNF HCL2 15469594 658539 Regulation TNF HCL3 15469594 658540 Regulation TNF HCLS1 8666940 1597389 Regulation TNF HDAC3 23559860 1915761 Regulation TNF HDAC3 24039666 2844428 Regulation TNF HDAC4 25187650 1830519 Regulation TNF HDAC4 25187650 1830524 Regulation TNF HGF 25762184 1623436 Regulation TNF HGS 25298686 2248193 Regulation TNF HGS 25298686 2248194 Regulation TNF HLA-A 19802382 2427601 Regulation TNF HLA-E 23226431 2724752 Regulation TNF HMGB1 18346273 110182 Regulation TNF HMGB1 21660935 808360 Regulation TNF HMGB1 21871094 123920 Regulation TNF HMGB1 23209806 2723134 Regulation TNF HMGB1 23874764 2822479 Regulation TNF HMGB1 24204700 2873510 Regulation TNF HMGB1 24578610 1085066 Regulation TNF HMGB1 25048472 3233752 Regulation TNF HNRNPF 12437786 1733978 Regulation TNF HNRNPF 19370157 2413294 Regulation TNF HNRNPH1 12437786 1733979 Regulation TNF HNRNPH1 19370157 2413295 Regulation TNF HPD 21124909 2484549 Regulation TNF HPD 21124909 2484573 Regulation TNF HPD 21124909 2484577 Regulation TNF HPD 21357587 3177783 Regulation TNF HPD 24260295 2883670 Regulation TNF HPD 25535478 1615727 Regulation TNF HPSE 20419162 2447182 Regulation TNF HPSE2 25059987 380670 Regulation TNF HRAS 25526565 1136157 Regulation TNF HRH4 23532396 1050505 Regulation TNF HSF1 25053922 1627946 Regulation TNF HSP90AA1 23516526 2768253 Regulation TNF HSPD1 22900050 2674939 Regulation TNF HSPG2 14583784 423748 Regulation TNF HSPG2 8760826 1598988 Regulation TNF HSPG2 8760826 1598992 Regulation TNF ICAM1 22771595 1045188 Regulation TNF ICAM1 23592916 1915853 Regulation TNF ID1 20010941 434211 Regulation TNF ID1 20010941 434212 Regulation TNF ID1 20010941 434217 Regulation TNF ID1 20010941 434223 Regulation TNF ID1 20010941 434224 Regulation TNF ID1 20010941 434226 Regulation TNF ID1 20010941 434227 Regulation TNF ID1 20010941 434231 Regulation TNF IER3 24945926 2359926 Regulation TNF IFIT2 19108715 352539 Regulation TNF IFN1@ 2450953 1574924 Regulation TNF IFNG 11577996 1737882 Regulation TNF IFNG 1512539 1532290 Regulation TNF IFNG 18474096 110752 Regulation TNF IFNG 18553155 3090098 Regulation TNF IFNG 20174649 2441594 Regulation TNF IFNG 23755050 907406 Regulation TNF IGF1 21371294 1657863 Regulation TNF IGF1 21371294 1657864 Regulation TNF IGF1 21371294 1657865 Regulation TNF IGF1 21371294 1657935 Regulation TNF IGF1 21371294 1657936 Regulation TNF IGF1 21371294 1657973 Regulation TNF IGFBP3 23383064 2747758 Regulation TNF IGFBP3 23592916 1915854 Regulation TNF IGFBP3 23592916 1915855 Regulation TNF IGKV1-27 24747594 1126210 Regulation TNF IGKV1-27 24917867 913090 Regulation TNF IKBKB 16177180 2017697 Regulation TNF IKBKB 25762184 1623434 Regulation TNF IKBKB 9841930 1604801 Regulation TNF IKBKG 16177180 2017698 Regulation TNF IKBKG 19373245 546090 Regulation TNF IKBKG 25762184 1623435 Regulation TNF IKBKG 9841930 1604802 Regulation TNF IL10 10880525 1516042 Regulation TNF IL10 11304549 1519261 Regulation TNF IL10 11545248 1737852 Regulation TNF IL10 11850581 1632870 Regulation TNF IL10 11850581 1632881 Regulation TNF IL10 15154610 629981 Regulation TNF IL10 17392587 1741409 Regulation TNF IL10 17392587 1741413 Regulation TNF IL10 17997848 1727765 Regulation TNF IL10 19203382 112787 Regulation TNF IL10 1940799 1554709 Regulation TNF IL10 19451266 1554829 Regulation TNF IL10 19771178 2214657 Regulation TNF IL10 19907653 2430901 Regulation TNF IL10 20594330 119163 Regulation TNF IL10 20706538 1049598 Regulation TNF IL10 21269456 3213915 Regulation TNF IL10 21599903 1658447 Regulation TNF IL10 21949832 2556694 Regulation TNF IL10 21949832 2556752 Regulation TNF IL10 21949832 2556782 Regulation TNF IL10 21949832 2556788 Regulation TNF IL10 22458733 412041 Regulation TNF IL10 22646809 1728184 Regulation TNF IL10 22873651 3204393 Regulation TNF IL10 22989378 381954 Regulation TNF IL10 23168705 1045227 Regulation TNF IL10 23272193 2730125 Regulation TNF IL10 23509800 180372 Regulation TNF IL10 23980096 1573518 Regulation TNF IL10 24314293 314627 Regulation TNF IL10 24314293 314628 Regulation TNF IL10 24382974 639484 Regulation TNF IL10 24456582 1701257 Regulation TNF IL10 24492460 1940531 Regulation TNF IL10 24520210 1062385 Regulation TNF IL10 24911280 2977602 Regulation TNF IL10 25187652 1621074 Regulation TNF IL10 25642189 955149 Regulation TNF IL10 7525853 1589721 Regulation TNF IL10 7964475 1593464 Regulation TNF IL12A 19492047 2418010 Regulation TNF IL12A 22194770 633890 Regulation TNF IL12A 23202920 1098604 Regulation TNF IL12A 23533314 1751872 Regulation TNF IL12A 23853585 3062962 Regulation TNF IL12A 23959031 3217829 Regulation TNF IL12A 24273539 909917 Regulation TNF IL12A 24982658 913165 Regulation TNF IL12A 25061260 1760261 Regulation TNF IL12B 19492047 2418011 Regulation TNF IL12B 22194770 633891 Regulation TNF IL12B 23202920 1098605 Regulation TNF IL12B 23533314 1751873 Regulation TNF IL12B 23853585 3062963 Regulation TNF IL12B 23959031 3217830 Regulation TNF IL12B 24273539 909918 Regulation TNF IL12B 24982658 913166 Regulation TNF IL12B 25061260 1760262 Regulation TNF IL13 20182640 631851 Regulation TNF IL13 23554645 1225854 Regulation TNF IL15 22888423 97655 Regulation TNF IL17A 16185356 3105690 Regulation TNF IL17A 19014637 463268 Regulation TNF IL17A 20169058 2370637 Regulation TNF IL17A 20571894 1491250 Regulation TNF IL17A 21294864 121389 Regulation TNF IL17A 21294864 121404 Regulation TNF IL17A 22028860 2564573 Regulation TNF IL17A 22171994 1864510 Regulation TNF IL17A 25250801 3010015 Regulation TNF IL17D 23049843 2699599 Regulation TNF IL18 11489953 1520482 Regulation TNF IL18 14979936 100110 Regulation TNF IL18 19178691 659109 Regulation TNF IL1A 12137246 1738162 Regulation TNF IL1A 18472791 1766938 Regulation TNF IL1A 18475489 1744020 Regulation TNF IL1A 19570027 137398 Regulation TNF IL1A 20380722 118654 Regulation TNF IL1A 20693346 716064 Regulation TNF IL1A 20890434 1635296 Regulation TNF IL1A 21477368 3112049 Regulation TNF IL1A 2161898 1563990 Regulation TNF IL1A 21629785 2525658 Regulation TNF IL1A 21682898 122877 Regulation TNF IL1A 21961050 2224087 Regulation TNF IL1A 22419920 95174 Regulation TNF IL1A 22455445 336080 Regulation TNF IL1A 22496641 3055979 Regulation TNF IL1A 23516523 2768192 Regulation TNF IL1A 23516523 2768224 Regulation TNF IL1A 23642074 1666689 Regulation TNF IL1A 23814544 684713 Regulation TNF IL1A 23889808 1627683 Regulation TNF IL1A 24192345 295264 Regulation TNF IL1A 24249711 1158343 Regulation TNF IL1A 24283517 130108 Regulation TNF IL1A 24446482 1415325 Regulation TNF IL1A 24705335 2949070 Regulation TNF IL1A 24982891 193528 Regulation TNF IL1A 25412085 3028956 Regulation TNF IL1A 2647895 1577615 Regulation TNF IL1A 8064221 1593920 Regulation TNF IL1B 18553155 3090099 Regulation TNF IL1B 23451225 2758406 Regulation TNF IL1B 25147565 1074707 Regulation TNF IL1RN 23451225 2758407 Regulation TNF IL1RN 23577023 3076683 Regulation TNF IL2 1955461 1367377 Regulation TNF IL2 2206945 437999 Regulation TNF IL2 22132075 2573986 Regulation TNF IL2 22216206 2584610 Regulation TNF IL2 7841036 444445 Regulation TNF IL2 8064221 1593913 Regulation TNF IL2 8064221 1593921 Regulation TNF IL2 8064221 1593927 Regulation TNF IL20 21844205 1564844 Regulation TNF IL20 21844205 1564847 Regulation TNF IL21 24574581 1757521 Regulation TNF IL22 21897855 2549858 Regulation TNF IL2RB 19570027 137399 Regulation TNF IL3 3049913 1579818 Regulation TNF IL32 19351384 357976 Regulation TNF IL37 25226272 3007705 Regulation TNF IL4 10704085 1736968 Regulation TNF IL4 11850581 1632871 Regulation TNF IL4 11850581 1632882 Regulation TNF IL4 14638848 1529855 Regulation TNF IL4 14638848 1529856 Regulation TNF IL4 14638848 1529857 Regulation TNF IL4 14638848 1529858 Regulation TNF IL4 14638848 1529875 Regulation TNF IL4 14638848 1529876 Regulation TNF IL4 14638848 1529912 Regulation TNF IL4 18475655 1745172 Regulation TNF IL4 18475657 1745187 Regulation TNF IL4 20182640 631852 Regulation TNF IL4 20701773 1657114 Regulation TNF IL4 22132075 2573995 Regulation TNF IL4 22989378 381955 Regulation TNF IL4 24314293 314629 Regulation TNF IL4 24314293 314630 Regulation TNF IL4 24550673 1138203 Regulation TNF IL4 25387665 1050606 Regulation TNF IL5 9839698 1764090 Regulation TNF IL6 12137246 1738163 Regulation TNF IL6 12467526 1738284 Regulation TNF IL6 1512539 1532291 Regulation TNF IL6 16137392 658591 Regulation TNF IL6 16259641 395237 Regulation TNF IL6 16623957 1722635 Regulation TNF IL6 16642549 3230854 Regulation TNF IL6 17993753 1703967 Regulation TNF IL6 18416823 1722701 Regulation TNF IL6 18472791 1766939 Regulation TNF IL6 18475724 1745852 Regulation TNF IL6 19148295 1746435 Regulation TNF IL6 19188427 707881 Regulation TNF IL6 22369693 1661193 Regulation TNF IL6 22606066 3152814 Regulation TNF IL6 22646809 1728185 Regulation TNF IL6 22679491 2650114 Regulation TNF IL6 22911786 2676468 Regulation TNF IL6 23239116 1239220 Regulation TNF IL6 23271367 1100126 Regulation TNF IL6 23382717 972513 Regulation TNF IL6 23642074 1666690 Regulation TNF IL6 24040434 2372100 Regulation TNF IL6 24391507 3065937 Regulation TNF IL6 24600449 911352 Regulation TNF IL6 24988414 2986171 Regulation TNF IL6 25105150 1496621 Regulation TNF IL6 25479553 3032322 Regulation TNF IL6 8145042 1594268 Regulation TNF IL6ST 20530204 1558454 Regulation TNF IL8 16008840 3105101 Regulation TNF IL8 18475483 1743986 Regulation TNF IL8 23189190 2722342 Regulation TNF IL8 23823136 2808708 Regulation TNF IL8 24892615 653898 Regulation TNF INS 19188427 707882 Regulation TNF INS 21054880 508271 Regulation TNF INS 21054880 508280 Regulation TNF INS 22536561 1920870 Regulation TNF INS 22550485 1072972 Regulation TNF INSR 22942720 1097118 Regulation TNF INTS2 24791061 1694376 Regulation TNF IRAK1 16606665 1539945 Regulation TNF IRAK1 22496647 3056094 Regulation TNF IRAK1 24106612 1152206 Regulation TNF IRAK1BP1 18268037 1549373 Regulation TNF IRAK2 23824036 2808880 Regulation TNF IRAK3 23634235 2225815 Regulation TNF IRAK3 23634235 2225817 Regulation TNF IRF1 19487420 1554882 Regulation TNF IRF1 23514422 1683711 Regulation TNF IRF2 23514422 1683712 Regulation TNF IRF3 18617992 3041644 Regulation TNF IRF3 22916150 2680090 Regulation TNF IRF3 23514422 1683713 Regulation TNF IRF3 23799152 2807430 Regulation TNF IRF4 23514422 1683714 Regulation TNF IRF5 23514422 1683715 Regulation TNF IRF5 24788560 2959163 Regulation TNF IRF6 23514422 1683716 Regulation TNF IRF7 18617992 3041617 Regulation TNF IRF7 18617992 3041618 Regulation TNF IRF7 22916150 2680091 Regulation TNF IRF7 23514422 1683717 Regulation TNF IRF8 19487420 1554881 Regulation TNF IRF8 23514422 1683710 Regulation TNF IRF9 23514422 1683718 Regulation TNF IRS1 22942720 1097119 Regulation TNF ITGAM 25036109 2990564 Regulation TNF ITGB2 2565948 1577429 Regulation TNF ITIH4 24884548 1668085 Regulation TNF ITIH4 24884548 1668086 Regulation TNF JAK1 21254404 775850 Regulation TNF JAK2 21254404 775851 Regulation TNF JAK3 21254404 775852 Regulation TNF JUN 12361922 791232 Regulation TNF JUN 18558008 323725 Regulation TNF JUN 20507572 353443 Regulation TNF JUN 21314908 3209832 Regulation TNF JUN 21755026 1081990 Regulation TNF JUN 22933572 1807243 Regulation TNF JUN 23173923 381160 Regulation TNF JUN 23762271 2802853 Regulation TNF KIR3DL1 8760835 1599068 Regulation TNF KLF4 24470523 1159228 Regulation TNF KLF5 16500892 2019654 Regulation TNF KLF5 25197166 1761947 Regulation TNF KLK3 23728723 17886 Regulation TNF KLRC1 24516120 1575043 Regulation TNF KLRC1 PMC4288483 1623801 Regulation TNF KRAS 25526565 1136158 Regulation TNF KRR1 21119000 1783900 Regulation TNF KRR1 22297296 554137 Regulation TNF KRR1 23788031 563000 Regulation TNF LAMC2 24990076 742221 Regulation TNF LBH 25054063 1623611 Regulation TNF LBP 20846396 353609 Regulation TNF LCT 22039370 1038368 Regulation TNF LCT 22039370 1038389 Regulation TNF LEO1 14580106 3228349 Regulation TNF LEP 15203568 1739682 Regulation TNF LEP 19888448 2430238 Regulation TNF LEP 19888448 2430239 Regulation TNF LEP 20607056 1681554 Regulation TNF LEP 20607056 1681555 Regulation TNF LEP 20607056 1681560 Regulation TNF LEP 22947075 337394 Regulation TNF LEP 23593289 2780588 Regulation TNF LIN28A 25313561 3015273 Regulation TNF LITAF 21633715 1912781 Regulation TNF LITAF 21984950 2561246 Regulation TNF LITAF 21984950 2561247 Regulation TNF LITAF 21984950 2561250 Regulation TNF LITAF 21984950 2561251 Regulation TNF LNPEP 7530759 1589922 Regulation TNF LPA 25172490 1621056 Regulation TNF LSS 22518279 1079937 Regulation TNF LSS 22518279 1079954 Regulation TNF LSS 22518279 1079974 Regulation TNF LTA 24349012 2896571 Regulation TNF LTA 24349012 2896615 Regulation TNF LTA 24349012 2896616 Regulation TNF LTA 24349012 2896630 Regulation TNF LTA 25078879 660748 Regulation TNF LTA 25530682 1763428 Regulation TNF LTF 22708778 356000 Regulation TNF LTF 23547923 1725723 Regulation TNF LTF PMC3495428 661106 Regulation TNF MAP2K1 19590712 1489515 Regulation TNF MAP2K1 21054880 508253 Regulation TNF MAP2K1 21871121 1659639 Regulation TNF MAP2K1 22069638 3182920 Regulation TNF MAP2K1 23642074 1666670 Regulation TNF MAP2K2 19590712 1489516 Regulation TNF MAP2K3 19590712 1489517 Regulation TNF MAP2K3 24349164 2896896 Regulation TNF MAP2K4 19590712 1489518 Regulation TNF MAP2K5 19590712 1489519 Regulation TNF MAP2K6 19590712 1489520 Regulation TNF MAP2K7 19590712 1489521 Regulation TNF MAP3K11 21194439 1657668 Regulation TNF MAP3K5 21119000 1783901 Regulation TNF MAP3K7 16987412 384043 Regulation TNF MAP3K7 22313861 3160957 Regulation TNF MAP3K7 22348103 2596858 Regulation TNF MAP3K8 15575964 1844344 Regulation TNF MAP3K8 15575964 1844355 Regulation TNF MAP3K8 19808894 711284 Regulation TNF MAP3K8 23557442 151366 Regulation TNF MAP3K8 23557442 151383 Regulation TNF MAPK1 16542479 105574 Regulation TNF MAPK1 16581537 792547 Regulation TNF MAPK1 16581537 792601 Regulation TNF MAPK1 18478117 2388673 Regulation TNF MAPK1 18478117 2388769 Regulation TNF MAPK1 19570027 137400 Regulation TNF MAPK1 20056579 793838 Regulation TNF MAPK1 20089176 284020 Regulation TNF MAPK1 21451502 1918369 Regulation TNF MAPK1 21547253 1749003 Regulation TNF MAPK1 21682898 122982 Regulation TNF MAPK1 22524232 1661915 Regulation TNF MAPK1 22611435 814330 Regulation TNF MAPK1 22973314 1068897 Regulation TNF MAPK1 23549267 1104857 Regulation TNF MAPK1 23549267 1105269 Regulation TNF MAPK1 23587438 1666545 Regulation TNF MAPK1 23587438 1666570 Regulation TNF MAPK1 23936634 140779 Regulation TNF MAPK1 24376635 2901571 Regulation TNF MAPK1 24376635 2901584 Regulation TNF MAPK1 24381514 3155644 Regulation TNF MAPK1 24566135 1124024 Regulation TNF MAPK1 24566135 1124043 Regulation TNF MAPK1 25180066 2230004 Regulation TNF MAPK10 16542479 105575 Regulation TNF MAPK10 16581537 792548 Regulation TNF MAPK10 16581537 792602 Regulation TNF MAPK10 18478117 2388674 Regulation TNF MAPK10 18478117 2388770 Regulation TNF MAPK10 19570027 137401 Regulation TNF MAPK10 20056579 793839 Regulation TNF MAPK10 20089176 284021 Regulation TNF MAPK10 21451502 1918370 Regulation TNF MAPK10 21547253 1749004 Regulation TNF MAPK10 21682898 122983 Regulation TNF MAPK10 22524232 1661916 Regulation TNF MAPK10 22611435 814331 Regulation TNF MAPK10 22973314 1068898 Regulation TNF MAPK10 23549267 1104858 Regulation TNF MAPK10 23549267 1105270 Regulation TNF MAPK10 23936634 140780 Regulation TNF MAPK10 24376635 2901572 Regulation TNF MAPK10 24376635 2901585 Regulation TNF MAPK10 24381514 3155645 Regulation TNF MAPK10 24566135 1124025 Regulation TNF MAPK10 24566135 1124044 Regulation TNF MAPK10 25180066 2230005 Regulation TNF MAPK11 16542479 105576 Regulation TNF MAPK11 16581537 792549 Regulation TNF MAPK11 16581537 792603 Regulation TNF MAPK11 18478117 2388675 Regulation TNF MAPK11 18478117 2388771 Regulation TNF MAPK11 19570027 137402 Regulation TNF MAPK11 20056579 793840 Regulation TNF MAPK11 20089176 284022 Regulation TNF MAPK11 21451502 1918371 Regulation TNF MAPK11 21547253 1749005 Regulation TNF MAPK11 21682898 122984 Regulation TNF MAPK11 22524232 1661917 Regulation TNF MAPK11 22611435 814332 Regulation TNF MAPK11 22973314 1068899 Regulation TNF MAPK11 23549267 1104859 Regulation TNF MAPK11 23549267 1105271 Regulation TNF MAPK11 23936634 140781 Regulation TNF MAPK11 24376635 2901573 Regulation TNF MAPK11 24376635 2901586 Regulation TNF MAPK11 24381514 3155646 Regulation TNF MAPK11 24566135 1124026 Regulation TNF MAPK11 24566135 1124045 Regulation TNF MAPK11 25180066 2230006 Regulation TNF MAPK12 16542479 105577 Regulation TNF MAPK12 16581537 792550 Regulation TNF MAPK12 16581537 792604 Regulation TNF MAPK12 18478117 2388676 Regulation TNF MAPK12 18478117 2388772 Regulation TNF MAPK12 19570027 137403 Regulation TNF MAPK12 20056579 793841 Regulation TNF MAPK12 20089176 284023 Regulation TNF MAPK12 21451502 1918372 Regulation TNF MAPK12 21547253 1749006 Regulation TNF MAPK12 21682898 122985 Regulation TNF MAPK12 22524232 1661918 Regulation TNF MAPK12 22611435 814333 Regulation TNF MAPK12 22973314 1068900 Regulation TNF MAPK12 23549267 1104860 Regulation TNF MAPK12 23549267 1105272 Regulation TNF MAPK12 23936634 140782 Regulation TNF MAPK12 24376635 2901574 Regulation TNF MAPK12 24376635 2901587 Regulation TNF MAPK12 24381514 3155647 Regulation TNF MAPK12 24566135 1124027 Regulation TNF MAPK12 24566135 1124046 Regulation TNF MAPK12 25180066 2230007 Regulation TNF MAPK13 16542479 105578 Regulation TNF MAPK13 16581537 792551 Regulation TNF MAPK13 16581537 792605 Regulation TNF MAPK13 18478117 2388677 Regulation TNF MAPK13 18478117 2388773 Regulation TNF MAPK13 19570027 137404 Regulation TNF MAPK13 20056579 793842 Regulation TNF MAPK13 20089176 284024 Regulation TNF MAPK13 21451502 1918373 Regulation TNF MAPK13 21547253 1749007 Regulation TNF MAPK13 21682898 122986 Regulation TNF MAPK13 22524232 1661919 Regulation TNF MAPK13 22611435 814334 Regulation TNF MAPK13 22973314 1068901 Regulation TNF MAPK13 23549267 1104861 Regulation TNF MAPK13 23549267 1105273 Regulation TNF MAPK13 23936634 140783 Regulation TNF MAPK13 24376635 2901575 Regulation TNF MAPK13 24376635 2901588 Regulation TNF MAPK13 24381514 3155648 Regulation TNF MAPK13 24566135 1124028 Regulation TNF MAPK13 24566135 1124047 Regulation TNF MAPK13 25180066 2230008 Regulation TNF MAPK14 16542479 105579 Regulation TNF MAPK14 16581537 792552 Regulation TNF MAPK14 16581537 792606 Regulation TNF MAPK14 18478117 2388678 Regulation TNF MAPK14 18478117 2388774 Regulation TNF MAPK14 19570027 137405 Regulation TNF MAPK14 20056579 793843 Regulation TNF MAPK14 20089176 284025 Regulation TNF MAPK14 21451502 1918374 Regulation TNF MAPK14 21547253 1749008 Regulation TNF MAPK14 21682898 122987 Regulation TNF MAPK14 22524232 1661920 Regulation TNF MAPK14 22611435 814335 Regulation TNF MAPK14 22973314 1068902 Regulation TNF MAPK14 23549267 1104862 Regulation TNF MAPK14 23549267 1105274 Regulation TNF MAPK14 23936634 140784 Regulation TNF MAPK14 24376635 2901576 Regulation TNF MAPK14 24376635 2901589 Regulation TNF MAPK14 24381514 3155649 Regulation TNF MAPK14 24566135 1124029 Regulation TNF MAPK14 24566135 1124048 Regulation TNF MAPK14 25180066 2230009 Regulation TNF MAPK15 16542479 105573 Regulation TNF MAPK15 16581537 792546 Regulation TNF MAPK15 16581537 792600 Regulation TNF MAPK15 18478117 2388672 Regulation TNF MAPK15 18478117 2388768 Regulation TNF MAPK15 19570027 137397 Regulation TNF MAPK15 20056579 793837 Regulation TNF MAPK15 20089176 284019 Regulation TNF MAPK15 21451502 1918368 Regulation TNF MAPK15 21547253 1749002 Regulation TNF MAPK15 21682898 122981 Regulation TNF MAPK15 22524232 1661914 Regulation TNF MAPK15 22611435 814329 Regulation TNF MAPK15 22973314 1068893 Regulation TNF MAPK15 23549267 1104856 Regulation TNF MAPK15 23549267 1105268 Regulation TNF MAPK15 23936634 140778 Regulation TNF MAPK15 24376635 2901570 Regulation TNF MAPK15 24376635 2901583 Regulation TNF MAPK15 24381514 3155643 Regulation TNF MAPK15 24566135 1124023 Regulation TNF MAPK15 24566135 1124042 Regulation TNF MAPK15 25180066 2230003 Regulation TNF MAPK3 10815618 1737083 Regulation TNF MAPK3 16542479 105580 Regulation TNF MAPK3 16581537 792553 Regulation TNF MAPK3 16581537 792607 Regulation TNF MAPK3 18478117 2388679 Regulation TNF MAPK3 18478117 2388775 Regulation TNF MAPK3 19570027 137406 Regulation TNF MAPK3 20056579 793844 Regulation TNF MAPK3 20089176 284026 Regulation TNF MAPK3 21451502 1918375 Regulation TNF MAPK3 21547253 1749009 Regulation TNF MAPK3 21682898 122988 Regulation TNF MAPK3 22279582 2590812 Regulation TNF MAPK3 22379572 1710335 Regulation TNF MAPK3 22524232 1661921 Regulation TNF MAPK3 22611435 814336 Regulation TNF MAPK3 22662179 2647142 Regulation TNF MAPK3 22973314 1068903 Regulation TNF MAPK3 23227067 3204532 Regulation TNF MAPK3 23227067 3204548 Regulation TNF MAPK3 23549267 1104863 Regulation TNF MAPK3 23549267 1105275 Regulation TNF MAPK3 23587438 1666546 Regulation TNF MAPK3 23587438 1666571 Regulation TNF MAPK3 23671886 1495257 Regulation TNF MAPK3 23936634 140785 Regulation TNF MAPK3 24069363 2853086 Regulation TNF MAPK3 24304472 1482149 Regulation TNF MAPK3 24376635 2901577 Regulation TNF MAPK3 24376635 2901590 Regulation TNF MAPK3 24381514 3155650 Regulation TNF MAPK3 24566135 1124030 Regulation TNF MAPK3 24566135 1124049 Regulation TNF MAPK3 25180066 2230010 Regulation TNF MAPK4 16542479 105581 Regulation TNF MAPK4 16581537 792554 Regulation TNF MAPK4 16581537 792608 Regulation TNF MAPK4 18478117 2388680 Regulation TNF MAPK4 18478117 2388776 Regulation TNF MAPK4 19570027 137407 Regulation TNF MAPK4 20056579 793845 Regulation TNF MAPK4 20089176 284027 Regulation TNF MAPK4 21451502 1918376 Regulation TNF MAPK4 21547253 1749010 Regulation TNF MAPK4 21682898 122989 Regulation TNF MAPK4 22524232 1661922 Regulation TNF MAPK4 22611435 814337 Regulation TNF MAPK4 22973314 1068904 Regulation TNF MAPK4 23549267 1104864 Regulation TNF MAPK4 23549267 1105276 Regulation TNF MAPK4 23936634 140786 Regulation TNF MAPK4 24376635 2901578 Regulation TNF MAPK4 24376635 2901591 Regulation TNF MAPK4 24381514 3155651 Regulation TNF MAPK4 24566135 1124031 Regulation TNF MAPK4 24566135 1124050 Regulation TNF MAPK4 25180066 2230011 Regulation TNF MAPK6 16542479 105582 Regulation TNF MAPK6 16581537 792555 Regulation TNF MAPK6 16581537 792609 Regulation TNF MAPK6 18478117 2388681 Regulation TNF MAPK6 18478117 2388777 Regulation TNF MAPK6 19570027 137408 Regulation TNF MAPK6 20056579 793846 Regulation TNF MAPK6 20089176 284028 Regulation TNF MAPK6 21451502 1918377 Regulation TNF MAPK6 21547253 1749011 Regulation TNF MAPK6 21682898 122990 Regulation TNF MAPK6 22524232 1661923 Regulation TNF MAPK6 22611435 814338 Regulation TNF MAPK6 22973314 1068905 Regulation TNF MAPK6 23549267 1104865 Regulation TNF MAPK6 23549267 1105277 Regulation TNF MAPK6 23936634 140787 Regulation TNF MAPK6 24376635 2901579 Regulation TNF MAPK6 24376635 2901592 Regulation TNF MAPK6 24381514 3155652 Regulation TNF MAPK6 24566135 1124032 Regulation TNF MAPK6 24566135 1124051 Regulation TNF MAPK6 25180066 2230012 Regulation TNF MAPK7 16542479 105583 Regulation TNF MAPK7 16581537 792556 Regulation TNF MAPK7 16581537 792610 Regulation TNF MAPK7 18478117 2388682 Regulation TNF MAPK7 18478117 2388778 Regulation TNF MAPK7 19570027 137409 Regulation TNF MAPK7 20056579 793847 Regulation TNF MAPK7 20089176 284029 Regulation TNF MAPK7 21451502 1918378 Regulation TNF MAPK7 21547253 1749012 Regulation TNF MAPK7 21682898 122991 Regulation TNF MAPK7 22524232 1661924 Regulation TNF MAPK7 22611435 814339 Regulation TNF MAPK7 22973314 1068906 Regulation TNF MAPK7 23549267 1104866 Regulation TNF MAPK7 23549267 1105278 Regulation TNF MAPK7 23936634 140788 Regulation TNF MAPK7 24376635 2901580 Regulation TNF MAPK7 24376635 2901593 Regulation TNF MAPK7 24381514 3155653 Regulation TNF MAPK7 24566135 1124033 Regulation TNF MAPK7 24566135 1124052 Regulation TNF MAPK7 25180066 2230013 Regulation TNF MAPK8 16542479 105584 Regulation TNF MAPK8 16581537 792557 Regulation TNF MAPK8 16581537 792611 Regulation TNF MAPK8 18478117 2388683 Regulation TNF MAPK8 18478117 2388779 Regulation TNF MAPK8 19570027 137410 Regulation TNF MAPK8 20056579 793848 Regulation TNF MAPK8 20089176 284030 Regulation TNF MAPK8 21451502 1918379 Regulation TNF MAPK8 21547253 1749013 Regulation TNF MAPK8 21682898 122992 Regulation TNF MAPK8 22279582 2590813 Regulation TNF MAPK8 22524232 1661925 Regulation TNF MAPK8 22611435 814340 Regulation TNF MAPK8 22973314 1068907 Regulation TNF MAPK8 23549267 1104867 Regulation TNF MAPK8 23549267 1105279 Regulation TNF MAPK8 23936634 140789 Regulation TNF MAPK8 24376635 2901581 Regulation TNF MAPK8 24376635 2901594 Regulation TNF MAPK8 24381514 3155654 Regulation TNF MAPK8 24566135 1124034 Regulation TNF MAPK8 24566135 1124053 Regulation TNF MAPK8 25180066 2230014 Regulation TNF MAPK9 16542479 105585 Regulation TNF MAPK9 16581537 792558 Regulation TNF MAPK9 16581537 792612 Regulation TNF MAPK9 18478117 2388684 Regulation TNF MAPK9 18478117 2388780 Regulation TNF MAPK9 19570027 137411 Regulation TNF MAPK9 20056579 793849 Regulation TNF MAPK9 20089176 284031 Regulation TNF MAPK9 21451502 1918380 Regulation TNF MAPK9 21547253 1749014 Regulation TNF MAPK9 21682898 122993 Regulation TNF MAPK9 22524232 1661926 Regulation TNF MAPK9 22611435 814341 Regulation TNF MAPK9 22973314 1068908 Regulation TNF MAPK9 23549267 1104868 Regulation TNF MAPK9 23549267 1105280 Regulation TNF MAPK9 23936634 140790 Regulation TNF MAPK9 24376635 2901582 Regulation TNF MAPK9 24376635 2901595 Regulation TNF MAPK9 24381514 3155655 Regulation TNF MAPK9 24566135 1124035 Regulation TNF MAPK9 24566135 1124054 Regulation TNF MAPK9 25180066 2230015 Regulation TNF MAPKAPK2 19296855 400571 Regulation TNF MAPKAPK2 20230629 402480 Regulation TNF MAPKAPK2 22792454 1688957 Regulation TNF MAPKAPK2 22991685 1082669 Regulation TNF MAPKAPK2 23028373 2338487 Regulation TNF MAPKAPK2 25386251 696614 Regulation TNF MAPKAPK3 24705157 985043 Regulation TNF MBL2 18180310 1548243 Regulation TNF MBOAT1 23951185 2833670 Regulation TNF MBTPS1 22096531 2571673 Regulation TNF MBTPS1 24586752 2926276 Regulation TNF ME2 19707466 175869 Regulation TNF ME2 19707466 175870 Regulation TNF MEA1 23755184 2801868 Regulation TNF MEA1 24348730 824742 Regulation TNF MED1 20454616 2449520 Regulation TNF MED10 20454616 2449515 Regulation TNF MED11 20454616 2449518 Regulation TNF MED13 20454616 2449502 Regulation TNF MED13L 20454616 2449503 Regulation TNF MED14 20454616 2449507 Regulation TNF MED15 20454616 2449496 Regulation TNF MED16 20454616 2449498 Regulation TNF MED17 20454616 2449509 Regulation TNF MED18 20454616 2449514 Regulation TNF MED19 20454616 2449517 Regulation TNF MED20 20454616 2449497 Regulation TNF MED21 20454616 2449494 Regulation TNF MED22 20454616 2449495 Regulation TNF MED23 20454616 2449508 Regulation TNF MED24 20454616 2449504 Regulation TNF MED25 20454616 2449516 Regulation TNF MED26 20454616 2449510 Regulation TNF MED27 20454616 2449511 Regulation TNF MED29 20454616 2449506 Regulation TNF MED30 20454616 2449505 Regulation TNF MED31 20454616 2449513 Regulation TNF MED4 20454616 2449499 Regulation TNF MED6 20454616 2449500 Regulation TNF MED7 20454616 2449512 Regulation TNF MED8 20454616 2449501 Regulation TNF MET 25060092 850520 Regulation TNF MFGE8 22114683 2573412 Regulation TNF MIF 20939898 353690 Regulation TNF MIF 20939898 353740 Regulation TNF MIF 22496958 1680484 Regulation TNF MIF 22496958 1680485 Regulation TNF MIF 23451183 2758313 Regulation TNF MIF 24069610 184264 Regulation TNF MIP 8496676 1595576 Regulation TNF MLKL 23835476 611276 Regulation TNF MLKL 23835476 611279 Regulation TNF MME 23935680 822152 Regulation TNF MME 23935680 822155 Regulation TNF MMP1 21547259 1749164 Regulation TNF MMP1 22970361 2230938 Regulation TNF MMP1 25414771 206525 Regulation TNF MMP1 25414771 206591 Regulation TNF MMP1 PMC3301273 660922 Regulation TNF MMP10 21547259 1749165 Regulation TNF MMP10 22970361 2230939 Regulation TNF MMP10 25414771 206526 Regulation TNF MMP10 25414771 206592 Regulation TNF MMP11 21547259 1749166 Regulation TNF MMP11 22970361 2230940 Regulation TNF MMP11 25414771 206527 Regulation TNF MMP11 25414771 206593 Regulation TNF MMP12 21547259 1749167 Regulation TNF MMP12 22970361 2230941 Regulation TNF MMP12 23450717 960889 Regulation TNF MMP12 25414771 206528 Regulation TNF MMP12 25414771 206594 Regulation TNF MMP13 21547259 1749168 Regulation TNF MMP13 22970361 2230942 Regulation TNF MMP13 23723167 780902 Regulation TNF MMP13 23723167 780903 Regulation TNF MMP13 23723167 780908 Regulation TNF MMP13 25414771 206529 Regulation TNF MMP13 25414771 206595 Regulation TNF MMP14 21547259 1749169 Regulation TNF MMP14 22970361 2230943 Regulation TNF MMP14 25414771 206530 Regulation TNF MMP14 25414771 206596 Regulation TNF MMP15 21547259 1749170 Regulation TNF MMP15 22970361 2230944 Regulation TNF MMP15 25414771 206531 Regulation TNF MMP15 25414771 206597 Regulation TNF MMP16 21547259 1749171 Regulation TNF MMP16 22970361 2230945 Regulation TNF MMP16 25414771 206532 Regulation TNF MMP16 25414771 206598 Regulation TNF MMP17 21547259 1749172 Regulation TNF MMP17 22970361 2230946 Regulation TNF MMP17 25414771 206533 Regulation TNF MMP17 25414771 206599 Regulation TNF MMP19 21547259 1749173 Regulation TNF MMP19 22970361 2230947 Regulation TNF MMP19 25414771 206534 Regulation TNF MMP19 25414771 206600 Regulation TNF MMP2 21547259 1749174 Regulation TNF MMP2 21573233 2523008 Regulation TNF MMP2 21573233 2523013 Regulation TNF MMP2 22970361 2230948 Regulation TNF MMP2 25414771 206535 Regulation TNF MMP2 25414771 206601 Regulation TNF MMP20 21547259 1749175 Regulation TNF MMP20 22970361 2230949 Regulation TNF MMP20 25414771 206536 Regulation TNF MMP20 25414771 206602 Regulation TNF MMP21 21547259 1749162 Regulation TNF MMP21 22970361 2230936 Regulation TNF MMP21 25414771 206523 Regulation TNF MMP21 25414771 206589 Regulation TNF MMP24 21547259 1749176 Regulation TNF MMP24 22970361 2230950 Regulation TNF MMP24 25414771 206537 Regulation TNF MMP24 25414771 206603 Regulation TNF MMP25 21547259 1749159 Regulation TNF MMP25 22970361 2230933 Regulation TNF MMP25 25414771 206520 Regulation TNF MMP25 25414771 206586 Regulation TNF MMP26 21547259 1749160 Regulation TNF MMP26 22970361 2230934 Regulation TNF MMP26 25414771 206521 Regulation TNF MMP26 25414771 206587 Regulation TNF MMP27 21547259 1749161 Regulation TNF MMP27 22970361 2230935 Regulation TNF MMP27 25414771 206522 Regulation TNF MMP27 25414771 206588 Regulation TNF MMP28 21547259 1749163 Regulation TNF MMP28 22970361 2230937 Regulation TNF MMP28 25414771 206524 Regulation TNF MMP28 25414771 206590 Regulation TNF MMP3 20380722 118655 Regulation TNF MMP3 21547259 1749177 Regulation TNF MMP3 22970361 2230951 Regulation TNF MMP3 25414771 206538 Regulation TNF MMP3 25414771 206604 Regulation TNF MMP7 21547259 1749178 Regulation TNF MMP7 22970361 2230952 Regulation TNF MMP7 25414771 206539 Regulation TNF MMP7 25414771 206605 Regulation TNF MMP8 21547259 1749179 Regulation TNF MMP8 22970361 2230953 Regulation TNF MMP8 23839109 1879626 Regulation TNF MMP8 25414771 206540 Regulation TNF MMP8 25414771 206606 Regulation TNF MMP9 21547259 1749180 Regulation TNF MMP9 22970361 2230954 Regulation TNF MMP9 25414771 206541 Regulation TNF MMP9 25414771 206607 Regulation TNF MOK 24625976 572994 Regulation TNF MSH2 14612916 423853 Regulation TNF MSH2 PMC2062908 448330 Regulation TNF MSH3 14612916 423854 Regulation TNF MSH3 PMC2062908 448331 Regulation TNF MSH4 14612916 423855 Regulation TNF MSH4 PMC2062908 448332 Regulation TNF MSH5 14612916 423856 Regulation TNF MSH5 PMC2062908 448333 Regulation TNF MSH6 14612916 423857 Regulation TNF MSH6 PMC2062908 448334 Regulation TNF MST1R 23817579 1042122 Regulation TNF MTOR 22363816 2602080 Regulation TNF MTOR 22363816 2602087 Regulation TNF MTTP 10815618 1737088 Regulation TNF MYD88 15197227 1532928 Regulation TNF MYD88 16304610 3039066 Regulation TNF MYD88 19079579 3042867 Regulation TNF MYD88 19122812 2404047 Regulation TNF MYD88 19753301 2426481 Regulation TNF MYD88 20204070 1213893 Regulation TNF MYD88 20886104 3048847 Regulation TNF MYD88 20886104 3048851 Regulation TNF MYD88 20939898 353712 Regulation TNF MYD88 21115688 1562064 Regulation TNF MYD88 21625574 3051962 Regulation TNF MYD88 21789039 979933 Regulation TNF MYD88 21809339 808393 Regulation TNF MYD88 22655058 2646746 Regulation TNF MYD88 23471913 740230 Regulation TNF MYD88 24285369 3138850 Regulation TNF MYD88 24758719 1483083 Regulation TNF MYD88 24904838 865252 Regulation TNF MYD88 25101851 2995934 Regulation TNF MYLIP 19918258 1041629 Regulation TNF MYLIP 21611196 2523852 Regulation TNF MYLIP 21611196 2523858 Regulation TNF MYLIP 21611196 2523863 Regulation TNF MYLIP 22518321 1079154 Regulation TNF MYLIP 22518321 1079158 Regulation TNF MYLIP 22558252 2624830 Regulation TNF MYLIP 22709905 1663504 Regulation TNF MYLIP 22829170 217865 Regulation TNF MYLIP 22900099 2675239 Regulation TNF MYLIP 22950459 1664995 Regulation TNF MYLIP 22950459 1664998 Regulation TNF MYLIP 22950459 1665003 Regulation TNF MYLIP 22950459 1665004 Regulation TNF MYLIP 22950459 1665007 Regulation TNF MYLIP 23056947 1145804 Regulation TNF MYLIP 23056947 1145811 Regulation TNF MYLIP 23143100 2081895 Regulation TNF MYLIP 23233675 1205869 Regulation TNF MYLIP 23638011 2786987 Regulation TNF MYLIP 23638011 2786988 Regulation TNF MYLIP 23979021 611305 Regulation TNF MYLIP 23979021 611306 Regulation TNF MYLIP 24351865 1122517 Regulation TNF MYLIP 24400890 1482492 Regulation TNF MYLIP 24475180 2915175 Regulation TNF MYLIP 24499489 346698 Regulation TNF MYLIP 24623979 3177135 Regulation TNF MYLIP 24688608 2208347 Regulation TNF MYLIP 24744457 738412 Regulation TNF MYLIP 24885472 1701851 Regulation TNF MYLIP 24885472 1701864 Regulation TNF MYLIP 24885472 1701865 Regulation TNF MYLIP 24885472 1701881 Regulation TNF MYLIP 24885472 1701884 Regulation TNF MYLIP 25083878 2993985 Regulation TNF MYLIP 25203514 3006384 Regulation TNF NA 14630568 830292 Regulation TNF NA 15312215 658532 Regulation TNF NA 23351387 695282 Regulation TNF NA 24001404 314586 Regulation TNF NA 24048773 745678 Regulation TNF NA 24048773 745679 Regulation TNF NAALADL1 17485511 1545736 Regulation TNF NAALADL1 24349012 2896609 Regulation TNF NAALADL1 25295753 3012773 Regulation TNF NAMPT 20546557 3118939 Regulation TNF NAMPT 24392007 2905153 Regulation TNF NBPF10 10732775 416675 Regulation TNF NCR1 22457623 3055892 Regulation TNF NCR1 22457623 3055898 Regulation TNF NCR1 24516120 1575044 Regulation TNF NELFCD 17322989 1606651 Regulation TNF NELFCD 18519801 706200 Regulation TNF NELFCD 22572815 1630798 Regulation TNF NELFCD 23006537 1024589 Regulation TNF NFAT5 16027109 2016906 Regulation TNF NFAT5 16027109 2016907 Regulation TNF NFAT5 16027109 2016910 Regulation TNF NFAT5 16027109 2016914 Regulation TNF NFAT5 21629436 672852 Regulation TNF NFAT5 23514422 1683719 Regulation TNF NFATC2 10952728 1516720 Regulation TNF NFATC2 10952728 1516727 Regulation TNF NFATC2 12361922 791233 Regulation TNF NFATC2 23110116 2706453 Regulation TNF NFATC2 7650486 1591373 Regulation TNF NFKB1 10815618 1737084 Regulation TNF NFKB1 11097212 702122 Regulation TNF NFKB1 18822146 161142 Regulation TNF NFKB1 20148136 1625877 Regulation TNF NFKB1 20178593 362439 Regulation TNF NFKB1 21127710 1748664 Regulation TNF NFKB1 22870920 239400 Regulation TNF NFKB1 22912686 2678519 Regulation TNF NFKB1 23028204 1750614 Regulation TNF NFKB1 23493408 1623980 Regulation TNF NFKB1 23762271 2802854 Regulation TNF NFKB1 24359561 3216062 Regulation TNF NFKB1 9841930 1604803 Regulation TNF NIT1 9362527 1602023 Regulation TNF NLRC4 21533069 3051567 Regulation TNF NLRP3 21533069 3051566 Regulation TNF NLRP3 22531291 1662114 Regulation TNF NLRP3 22531291 1662133 Regulation TNF NOD2 24498172 2918811 Regulation TNF NOS1 23781123 1753395 Regulation TNF NOS1 24744897 2251803 Regulation TNF NOS1 24995119 2229448 Regulation TNF NOS2 22570765 1680688 Regulation TNF NOS2 23318584 611087 Regulation TNF NOS2 24995119 2229449 Regulation TNF NOTCH1 21958395 1659838 Regulation TNF NOX1 16959029 1654961 Regulation TNF NOX1 25180066 2229968 Regulation TNF NOX1 25180066 2229972 Regulation TNF NOX3 16959029 1654962 Regulation TNF NOX3 25180066 2229969 Regulation TNF NOX3 25180066 2229973 Regulation TNF NOX4 16959029 1654963 Regulation TNF NOX4 22048166 553427 Regulation TNF NOX4 25180066 2229970 Regulation TNF NOX4 25180066 2229974 Regulation TNF NOX5 16959029 1654960 Regulation TNF NOX5 25180066 2229967 Regulation TNF NOX5 25180066 2229971 Regulation TNF NPY 15899028 102738 Regulation TNF NPY 25206918 2006501 Regulation TNF NPY 25206918 2006502 Regulation TNF NPY 25206918 2006560 Regulation TNF NRAS 25526565 1136159 Regulation TNF NRD1 22351606 778150 Regulation TNF NRG1 23936190 2829627 Regulation TNF NRG2 23936190 2829628 Regulation TNF NRG3 23936190 2829629 Regulation TNF NRG4 23936190 2829626 Regulation TNF NT5E 23520507 2768960 Regulation TNF NTRK1 20195389 1478636 Regulation TNF OMP 23720712 864036 Regulation TNF OPA1 20454616 2449519 Regulation TNF OPN1MW 21042286 12008 Regulation TNF OPTN 19096531 1908637 Regulation TNF OPTN 20436471 1948937 Regulation TNF OPTN 22675546 2649104 Regulation TNF OPTN 22690120 1914504 Regulation TNF P2RX4 22547202 3090958 Regulation TNF P2RX7 17367517 1624953 Regulation TNF P2RX7 17367517 1624966 Regulation TNF P2RX7 17367517 1624967 Regulation TNF P2RX7 18404430 3087323 Regulation TNF P2RX7 23210974 356115 Regulation TNF P2RX7 24146541 1916410 Regulation TNF P4HB 18680601 658969 Regulation TNF P4HB 18680601 658970 Regulation TNF P4HB 18680601 658971 Regulation TNF P4HB 18680601 658974 Regulation TNF P4HB 18680601 658976 Regulation TNF P4HB 18680601 658977 Regulation TNF PACS1 15498105 390237 Regulation TNF PACS2 15498105 390236 Regulation TNF PAEP 8855980 445731 Regulation TNF PAF1 14580106 3228347 Regulation TNF PAM 19753301 2426484 Regulation TNF PAM 21931706 2554190 Regulation TNF PAM 23189190 2722343 Regulation TNF PAM 24349012 2896572 Regulation TNF PAM 24349012 2896617 Regulation TNF PAM 24349012 2896618 Regulation TNF PAM 24349012 2896631 Regulation TNF PARK2 21124909 2484533 Regulation TNF PARK2 21124909 2484569 Regulation TNF PARK7 21124909 2484532 Regulation TNF PARK7 21124909 2484568 Regulation TNF PARK7 24963279 842114 Regulation TNF PARP1 25161822 452503 Regulation TNF PARP1 25161822 452507 Regulation TNF PC 23099484 795109 Regulation TNF PC 23099484 795111 Regulation TNF PCSK1 23190609 558246 Regulation TNF PCSK1 24198446 1755031 Regulation TNF PCSK2 20587063 402698 Regulation TNF PDLIM7 16104828 2368422 Regulation TNF PDLIM7 16573838 33389 Regulation TNF PDLIM7 16573838 33390 Regulation TNF PDLIM7 18331642 1625046 Regulation TNF PDLIM7 PMC1188257 2370119 Regulation TNF PGA3 22953221 3126947 Regulation TNF PGA4 22953221 3126948 Regulation TNF PGA5 22953221 3126949 Regulation TNF PI3 20148136 1625875 Regulation TNF PI3 PMC3273240 99577 Regulation TNF PIK3CA 11219394 98365 Regulation TNF PIK3CA 11879539 98576 Regulation TNF PIK3CA 12110137 99198 Regulation TNF PIK3CA 22973314 1068909 Regulation TNF PIK3CA 23514422 1683720 Regulation TNF PIK3CA 23514422 1683733 Regulation TNF PIK3R1 11219394 98366 Regulation TNF PIK3R1 11879539 98577 Regulation TNF PIK3R1 12110137 99199 Regulation TNF PIK3R1 22973314 1068910 Regulation TNF PIK3R1 23514422 1683721 Regulation TNF PIK3R1 23514422 1683734 Regulation TNF PINK1 21124909 2484531 Regulation TNF PINK1 21124909 2484567 Regulation TNF PLA2G1B 24592395 187426 Regulation TNF PLA2G1B PMC1968561 448070 Regulation TNF PLA2G4A 22066066 1636439 Regulation TNF PLAT 23408962 2753000 Regulation TNF PLD1 25047119 2990888 Regulation TNF PLK1 24205328 2875955 Regulation TNF PLK1 24205328 2875956 Regulation TNF PLK1 24205328 2875984 Regulation TNF PLK1 24205328 2875985 Regulation TNF PLK1 24205328 2875994 Regulation TNF PLK1 24205328 2876067 Regulation TNF PMS1 23593410 2781160 Regulation TNF PMS1 23593410 2781169 Regulation TNF PMS2 23593410 2781161 Regulation TNF PMS2 23593410 2781170 Regulation TNF PNLIP 25610476 827651 Regulation TNF PNLIP 25610476 827679 Regulation TNF POLDIP2 22069638 3182919 Regulation TNF POLDIP2 23227067 3204531 Regulation TNF POU5F1 22739622 1488818 Regulation TNF PPARA 22537532 1662211 Regulation TNF PPARG 15203568 1739650 Regulation TNF PPARG 21450068 732025 Regulation TNF PPP1R3A 17502003 626753 Regulation TNF PPP1R3A 22523542 2620154 Regulation TNF PPP1R3A 24979747 2985676 Regulation TNF PPP2CA 17967904 1547412 Regulation TNF PPP2R1A 17967904 1547413 Regulation TNF PPP2R2B 17967904 1547414 Regulation TNF PPP3CA 10952728 1516721 Regulation TNF PPP3CA 20507572 353445 Regulation TNF PPP3CB 10952728 1516722 Regulation TNF PPP3CC 10952728 1516723 Regulation TNF PPP3R1 20507572 353446 Regulation TNF PRDM1 23087693 904781 Regulation TNF PRDM1 23977359 2840063 Regulation TNF PRDX1 25024510 1760081 Regulation TNF PRDX2 20585389 2453859 Regulation TNF PRKAA1 22550592 1079165 Regulation TNF PRKAA1 23300870 2736894 Regulation TNF PRKAA1 23423573 726568 Regulation TNF PRKAA1 25007068 1128307 Regulation TNF PRKAA2 22550592 1079166 Regulation TNF PRKAA2 23300870 2736895 Regulation TNF PRKAA2 23423573 726569 Regulation TNF PRKAA2 25007068 1128308 Regulation TNF PRKAB1 22550592 1079167 Regulation TNF PRKAB1 23300870 2736896 Regulation TNF PRKAB1 23423573 726570 Regulation TNF PRKAB1 25007068 1128309 Regulation TNF PRKAB2 22550592 1079168 Regulation TNF PRKAB2 23300870 2736897 Regulation TNF PRKAB2 23423573 726571 Regulation TNF PRKAB2 25007068 1128310 Regulation TNF PRKACB 18568240 652525 Regulation TNF PRKACB 18568240 652526 Regulation TNF PRKACB 18568240 652527 Regulation TNF PRKACB 18568240 652658 Regulation TNF PRKACB 22384111 2604142 Regulation TNF PRKACB 22384111 2605937 Regulation TNF PRKACB 23284918 2731281 Regulation TNF PRKACG 18568240 652528 Regulation TNF PRKACG 18568240 652529 Regulation TNF PRKACG 18568240 652530 Regulation TNF PRKACG 18568240 652659 Regulation TNF PRKACG 22384111 2604143 Regulation TNF PRKACG 22384111 2605938 Regulation TNF PRKACG 23284918 2731282 Regulation TNF PRKAG1 22550592 1079169 Regulation TNF PRKAG1 23300870 2736898 Regulation TNF PRKAG1 23423573 726572 Regulation TNF PRKAG1 25007068 1128311 Regulation TNF PRKAG2 22550592 1079170 Regulation TNF PRKAG2 23300870 2736899 Regulation TNF PRKAG2 23423573 726573 Regulation TNF PRKAG2 25007068 1128312 Regulation TNF PRKAR1A 18568240 652531 Regulation TNF PRKAR1A 18568240 652532 Regulation TNF PRKAR1A 18568240 652533 Regulation TNF PRKAR1A 18568240 652660 Regulation TNF PRKAR1A 22384111 2604144 Regulation TNF PRKAR1A 22384111 2605939 Regulation TNF PRKAR1A 23284918 2731283 Regulation TNF PRKAR1B 18568240 652534 Regulation TNF PRKAR1B 18568240 652535 Regulation TNF PRKAR1B 18568240 652536 Regulation TNF PRKAR1B 18568240 652661 Regulation TNF PRKAR1B 22384111 2604145 Regulation TNF PRKAR1B 22384111 2605940 Regulation TNF PRKAR1B 23284918 2731284 Regulation TNF PRKAR2A 18568240 652537 Regulation TNF PRKAR2A 18568240 652538 Regulation TNF PRKAR2A 18568240 652539 Regulation TNF PRKAR2A 18568240 652662 Regulation TNF PRKAR2A 22384111 2604146 Regulation TNF PRKAR2A 22384111 2605941 Regulation TNF PRKAR2A 23284918 2731285 Regulation TNF PRKAR2B 18568240 652540 Regulation TNF PRKAR2B 18568240 652541 Regulation TNF PRKAR2B 18568240 652542 Regulation TNF PRKAR2B 18568240 652663 Regulation TNF PRKAR2B 22384111 2604147 Regulation TNF PRKAR2B 22384111 2605942 Regulation TNF PRKAR2B 23284918 2731286 Regulation TNF PRNP 24952384 1668267 Regulation TNF PRNP 24952384 1668270 Regulation TNF PRNP 24952384 1668274 Regulation TNF PROK1 24051059 3102702 Regulation TNF PTBP1 12437786 1733980 Regulation TNF PTBP1 19370157 2413296 Regulation TNF PTBP2 12437786 1733977 Regulation TNF PTBP2 19370157 2413293 Regulation TNF PTGS2 11405554 1737837 Regulation TNF PTGS2 11405554 1737838 Regulation TNF PTHLH 20953899 645853 Regulation TNF PTPN1 24590766 1575154 Regulation TNF PTPN7 24265715 2885016 Regulation TNF PTPN7 24265715 2885046 Regulation TNF PTPN7 24265715 2885051 Regulation TNF PTPN7 24265715 2885055 Regulation TNF PTPN7 24265715 2885056 Regulation TNF PTX3 18297211 652389 Regulation TNF PTX3 18568240 652543 Regulation TNF PTX3 18568240 652544 Regulation TNF PTX3 18568240 652545 Regulation TNF PTX3 18568240 652677 Regulation TNF PTX3 24959559 1154636 Regulation TNF PTX3 24959559 1154640 Regulation TNF PTX4 18297211 652388 Regulation TNF PTX4 18568240 652522 Regulation TNF PTX4 18568240 652523 Regulation TNF PTX4 18568240 652524 Regulation TNF PTX4 18568240 652676 Regulation TNF PTX4 24959559 1154635 Regulation TNF PTX4 24959559 1154639 Regulation TNF RAB6A 23437303 2756409 Regulation TNF RAD1 21371294 1657866 Regulation TNF RAD1 21371294 1657867 Regulation TNF RAD1 21371294 1657974 Regulation TNF RAD17 21371294 1657868 Regulation TNF RAD17 21371294 1657869 Regulation TNF RAD17 21371294 1657975 Regulation TNF RAD18 21371294 1657861 Regulation TNF RAD18 21371294 1657862 Regulation TNF RAD18 21371294 1657972 Regulation TNF RAD21 21371294 1657870 Regulation TNF RAD21 21371294 1657871 Regulation TNF RAD21 21371294 1657976 Regulation TNF RAD50 21371294 1657872 Regulation TNF RAD50 21371294 1657873 Regulation TNF RAD50 21371294 1657977 Regulation TNF RAD51 21371294 1657874 Regulation TNF RAD51 21371294 1657875 Regulation TNF RAD51 21371294 1657978 Regulation TNF RAD52 21371294 1657876 Regulation TNF RAD52 21371294 1657877 Regulation TNF RAD52 21371294 1657979 Regulation TNF RASSF1 24776599 514450 Regulation TNF RASSF1 24776599 514451 Regulation TNF RASSF1 24776599 514462 Regulation TNF RASSF1 24776599 514536 Regulation TNF RB1 25206809 2005940 Regulation TNF RB1 25535474 1615577 Regulation TNF RBCK1 23104095 1958263 Regulation TNF RBM10 23675440 2792936 Regulation TNF RBP4 19675137 710820 Regulation TNF RBPJ 22249448 1566866 Regulation TNF RBPJ 22249448 1566867 Regulation TNF RBPJ 22249448 1566908 Regulation TNF RELA 10815618 1737085 Regulation TNF RELA 11097212 702123 Regulation TNF RELA 18822146 161143 Regulation TNF RELA 20148136 1625878 Regulation TNF RELA 20178593 362440 Regulation TNF RELA 21127710 1748665 Regulation TNF RELA 22870920 239401 Regulation TNF RELA 22912686 2678520 Regulation TNF RELA 22996371 1029309 Regulation TNF RELA 23028204 1750615 Regulation TNF RELA 23762271 2802855 Regulation TNF RELA 24359561 3216063 Regulation TNF RELA 9841930 1604804 Regulation TNF RENBP 24876878 825957 Regulation TNF REV1 24040434 2372098 Regulation TNF REV1 24040434 2372099 Regulation TNF RGN 23670020 93309 Regulation TNF RIPK1 22075985 547608 Regulation TNF RIPK3 21368763 1987152 Regulation TNF RIPK3 22075985 547609 Regulation TNF RIPK3 23788031 562999 Regulation TNF RIPK3 24507727 271493 Regulation TNF RIPK3 24909514 18992 Regulation TNF RIPK3 25136567 197165 Regulation TNF RNF19A 20148136 1625876 Regulation TNF RNF19A 21197399 632181 Regulation TNF RNF19A 21682898 122980 Regulation TNF RNF19A 23227067 3204547 Regulation TNF RNF19A 23549267 1105267 Regulation TNF RNF19A 23587438 1666569 Regulation TNF RNF19A 23731466 357368 Regulation TNF RNF19A 25295284 1623306 Regulation TNF RNGTT 25012519 297602 Regulation TNF RNGTT 25012519 297603 Regulation TNF RPE 23133491 816228 Regulation TNF RPE 23133491 816229 Regulation TNF RPE 23133491 816236 Regulation TNF RPLP1 24663085 1125564 Regulation TNF RPS16 21172007 331815 Regulation TNF RTL1 25409514 3028769 Regulation TNF RTN4 23435238 3222297 Regulation TNF S100A12 15899028 102736 Regulation TNF S100A12 20529227 34833 Regulation TNF S100A12 20931347 1615907 Regulation TNF S100A8 16613612 105857 Regulation TNF S100A8 23619188 838813 Regulation TNF S100A9 23133376 3059968 Regulation TNF S100A9 23619188 838814 Regulation TNF SAA1 12110136 99148 Regulation TNF SAG 18685727 1908333 Regulation TNF SAMHD1 24116037 2864999 Regulation TNF SAMHD1 25106478 348483 Regulation TNF SDC2 16022734 1036133 Regulation TNF SDC2 16022734 1036134 Regulation TNF SDC2 16022734 1036139 Regulation TNF SEA 16614521 1634742 Regulation TNF SEA 2258710 1568229 Regulation TNF SELE 8551244 1595948 Regulation TNF SERPINB3 10732775 416674 Regulation TNF SERPINB3 21858034 2545812 Regulation TNF SERPINB3 21858034 2545814 Regulation TNF SERPINB6 25136575 197177 Regulation TNF SETBP1 16144553 312907 Regulation TNF SETBP1 16614521 1634743 Regulation TNF SETBP1 19001139 1552752 Regulation TNF SETBP1 24533103 2922273 Regulation TNF SETBP1 7520469 1589455 Regulation TNF SFRP1 24339864 2891236 Regulation TNF SFRP1 24339864 2891250 Regulation TNF SFRP1 24339864 2891271 Regulation TNF SH3BP2 22640988 2221127 Regulation TNF SIGLEC7 23288991 1915403 Regulation TNF SIRT1 22069489 2569152 Regulation TNF SIRT1 22069489 2569230 Regulation TNF SIRT1 23497276 388434 Regulation TNF SIRT1 24039666 2844390 Regulation TNF SIRT1 24039666 2844474 Regulation TNF SIRT2 24039666 2844389 Regulation TNF SIRT2 24039666 2844473 Regulation TNF SIRT3 24039666 2844391 Regulation TNF SIRT3 24039666 2844475 Regulation TNF SIRT4 24039666 2844392 Regulation TNF SIRT4 24039666 2844476 Regulation TNF SIRT5 24039666 2844393 Regulation TNF SIRT5 24039666 2844477 Regulation TNF SIRT6 19936064 2431680 Regulation TNF SIRT6 19936064 2431682 Regulation TNF SIRT6 24039666 2844394 Regulation TNF SIRT6 24039666 2844478 Regulation TNF SIRT6 24064057 220792 Regulation TNF SIRT7 24039666 2844395 Regulation TNF SIRT7 24039666 2844479 Regulation TNF SLAMF1 15123745 1532271 Regulation TNF SLC25A10 22723938 2655170 Regulation TNF SLC2A4 24349514 2898403 Regulation TNF SLCO6A1 10408834 414868 Regulation TNF SLCO6A1 22469910 1086631 Regulation TNF SLCO6A1 22469910 1086633 Regulation TNF SLPI 10449524 1512272 Regulation TNF SLPI 16352738 1538805 Regulation TNF SLPI 16352738 1538806 Regulation TNF SLPI 21912612 2552183 Regulation TNF SLPI 25514790 3034719 Regulation TNF SMAD2 23484152 179736 Regulation TNF SMAD3 23484152 179737 Regulation TNF SMAD7 23484152 179738 Regulation TNF SMOX 16008840 3105100 Regulation TNF SNAP25 11850581 1632880 Regulation TNF SOCS1 22973314 1068892 Regulation TNF SOCS1 23236370 2725994 Regulation TNF SOCS3 25352752 1917451 Regulation TNF SOCS3 25352752 1917452 Regulation TNF SOCS3 25352752 1917479 Regulation TNF SOD2 24885568 365028 Regulation TNF SOST 24286133 130375 Regulation TNF SP1 24391986 2905127 Regulation TNF SPHK1 20498849 2451142 Regulation TNF SPHK1 20498849 2451143 Regulation TNF SPHK1 20498849 2451191 Regulation TNF SPHK1 20634980 2455711 Regulation TNF SPHK1 21310085 1657772 Regulation TNF SPHK1 24586752 2926287 Regulation TNF SPHK2 24586752 2926288 Regulation TNF SPR 21085650 2482870 Regulation TNF SRC 23209344 1750705 Regulation TNF SRGN 21880179 623906 Regulation TNF SRL 12495444 1734009 Regulation TNF SRL 17498286 274425 Regulation TNF SRL 17498286 274426 Regulation TNF STAT1 24453411 1756655 Regulation TNF STAT3 19849823 117514 Regulation TNF STAT3 22174891 2582471 Regulation TNF STAT3 22937006 2682701 Regulation TNF STAT3 23979021 611327 Regulation TNF STAT3 24101903 962416 Regulation TNF STAT3 25092271 1087682 Regulation TNF STAT6 14638848 1529852 Regulation TNF STAT6 14638848 1529904 Regulation TNF STK10 11238593 1519001 Regulation TNF STK11 11238593 1519002 Regulation TNF STK16 11238593 1519003 Regulation TNF STK19 11238593 1519004 Regulation TNF STK24 11238593 1519005 Regulation TNF STK25 11238593 1519006 Regulation TNF STK3 11238593 1519007 Regulation TNF STK31 11238593 1519008 Regulation TNF STK33 11238593 1519010 Regulation TNF STK35 11238593 1519011 Regulation TNF STK36 11238593 1519012 Regulation TNF STK38 11238593 1519014 Regulation TNF STK39 11238593 1519013 Regulation TNF STK4 11238593 1519009 Regulation TNF STK40 11238593 1519015 Regulation TNF STS 21533069 3051565 Regulation TNF STS 22531291 1662113 Regulation TNF STS 22723924 2655129 Regulation TNF SYK 22883599 292359 Regulation TNF SYK 24340123 2372324 Regulation TNF SYK 25033445 3068700 Regulation TNF SYT1 20195489 26830 Regulation TNF SYT1 23448136 245404 Regulation TNF SYT1 24283517 130116 Regulation TNF TAB1 22313861 3160956 Regulation TNF TAB1 22348103 2596857 Regulation TNF TAT 19467159 3117924 Regulation TNF TAT 22039370 1038366 Regulation TNF TAT 22039370 1038387 Regulation TNF TAT 22591363 680524 Regulation TNF TAX1BP1 19609363 3044885 Regulation TNF TAZ 25502757 841160 Regulation TNF TBK1 21931631 2553719 Regulation TNF TBP 22247597 1490085 Regulation TNF TCF12 15987495 104013 Regulation TNF TCF12 16192667 1740087 Regulation TNF TCF12 22479453 2615397 Regulation TNF TCF12 22848841 1079262 Regulation TNF TCF12 23125487 1750669 Regulation TNF TCF12 23173923 381148 Regulation TNF TCF12 23481064 1045284 Regulation TNF TCF12 24078775 1754783 Regulation TNF TCF12 24591741 1046895 Regulation TNF TCF12 25210730 3006577 Regulation TNF TCF15 15987495 104014 Regulation TNF TCF15 16192667 1740088 Regulation TNF TCF15 22479453 2615398 Regulation TNF TCF15 22848841 1079263 Regulation TNF TCF15 23125487 1750670 Regulation TNF TCF15 23173923 381149 Regulation TNF TCF15 23481064 1045285 Regulation TNF TCF15 24078775 1754784 Regulation TNF TCF15 24591741 1046896 Regulation TNF TCF15 25210730 3006578 Regulation TNF TCF19 15987495 104015 Regulation TNF TCF19 16192667 1740089 Regulation TNF TCF19 22479453 2615399 Regulation TNF TCF19 22848841 1079264 Regulation TNF TCF19 23125487 1750671 Regulation TNF TCF19 23173923 381150 Regulation TNF TCF19 23481064 1045286 Regulation TNF TCF19 24078775 1754785 Regulation TNF TCF19 24591741 1046897 Regulation TNF TCF19 25210730 3006579 Regulation TNF TCF20 15987495 104016 Regulation TNF TCF20 16192667 1740090 Regulation TNF TCF20 22479453 2615400 Regulation TNF TCF20 22848841 1079265 Regulation TNF TCF20 23125487 1750672 Regulation TNF TCF20 23173923 381151 Regulation TNF TCF20 23481064 1045287 Regulation TNF TCF20 24078775 1754786 Regulation TNF TCF20 24591741 1046898 Regulation TNF TCF20 25210730 3006580 Regulation TNF TCF21 15987495 104017 Regulation TNF TCF21 16192667 1740091 Regulation TNF TCF21 22479453 2615401 Regulation TNF TCF21 22848841 1079266 Regulation TNF TCF21 23125487 1750673 Regulation TNF TCF21 23173923 381152 Regulation TNF TCF21 23481064 1045288 Regulation TNF TCF21 24078775 1754787 Regulation TNF TCF21 24591741 1046899 Regulation TNF TCF21 25210730 3006581 Regulation TNF TCF23 15987495 104021 Regulation TNF TCF23 16192667 1740095 Regulation TNF TCF23 22479453 2615405 Regulation TNF TCF23 22848841 1079270 Regulation TNF TCF23 23125487 1750677 Regulation TNF TCF23 23173923 381156 Regulation TNF TCF23 23481064 1045292 Regulation TNF TCF23 24078775 1754791 Regulation TNF TCF23 24591741 1046903 Regulation TNF TCF23 25210730 3006585 Regulation TNF TCF24 15987495 104023 Regulation TNF TCF24 16192667 1740097 Regulation TNF TCF24 22479453 2615407 Regulation TNF TCF24 22848841 1079272 Regulation TNF TCF24 23125487 1750679 Regulation TNF TCF24 23173923 381158 Regulation TNF TCF24 23481064 1045294 Regulation TNF TCF24 24078775 1754793 Regulation TNF TCF24 24591741 1046905 Regulation TNF TCF24 25210730 3006587 Regulation TNF TCF25 15987495 104022 Regulation TNF TCF25 16192667 1740096 Regulation TNF TCF25 22479453 2615406 Regulation TNF TCF25 22848841 1079271 Regulation TNF TCF25 23125487 1750678 Regulation TNF TCF25 23173923 381157 Regulation TNF TCF25 23481064 1045293 Regulation TNF TCF25 24078775 1754792 Regulation TNF TCF25 24591741 1046904 Regulation TNF TCF25 25210730 3006586 Regulation TNF TCF3 15987495 104018 Regulation TNF TCF3 16192667 1740092 Regulation TNF TCF3 22479453 2615402 Regulation TNF TCF3 22848841 1079267 Regulation TNF TCF3 23125487 1750674 Regulation TNF TCF3 23173923 381153 Regulation TNF TCF3 23481064 1045289 Regulation TNF TCF3 24078775 1754788 Regulation TNF TCF3 24591741 1046900 Regulation TNF TCF3 25210730 3006582 Regulation TNF TCF4 15987495 104019 Regulation TNF TCF4 16192667 1740093 Regulation TNF TCF4 22479453 2615403 Regulation TNF TCF4 22848841 1079268 Regulation TNF TCF4 23125487 1750675 Regulation TNF TCF4 23173923 381154 Regulation TNF TCF4 23481064 1045290 Regulation TNF TCF4 24078775 1754789 Regulation TNF TCF4 24591741 1046901 Regulation TNF TCF4 25210730 3006583 Regulation TNF TCF7 15987495 104020 Regulation TNF TCF7 16192667 1740094 Regulation TNF TCF7 22479453 2615404 Regulation TNF TCF7 22848841 1079269 Regulation TNF TCF7 23125487 1750676 Regulation TNF TCF7 23173923 381155 Regulation TNF TCF7 23481064 1045291 Regulation TNF TCF7 24078775 1754790 Regulation TNF TCF7 24591741 1046902 Regulation TNF TCF7 25210730 3006584 Regulation TNF TFAM 22469910 1086630 Regulation TNF TGFA 2295877 1569299 Regulation TNF TGFB1 3110354 1580013 Regulation TNF TGM4 22291795 95049 Regulation TNF THEMIS2 20644716 2455981 Regulation TNF THRSP 21297958 2498903 Regulation TNF THRSP 21390306 2506388 Regulation TNF THY1 20657842 2456464 Regulation TNF THY1 20657842 2456466 Regulation TNF TIA1 PMC3273100 99532 Regulation TNF TIMP1 21547259 1749158 Regulation TNF TIMP1 22558080 2624251 Regulation TNF TIRAP 22648407 1203384 Regulation TNF TIRAP 22648407 1203402 Regulation TNF TLE3 24244826 206034 Regulation TNF TLE3 24244826 206035 Regulation TNF TLE3 24244826 206043 Regulation TNF TLR1 16061725 1536972 Regulation TNF TLR1 17485511 1545651 Regulation TNF TLR1 17485512 1545793 Regulation TNF TLR1 17485512 1545900 Regulation TNF TLR1 17895997 2378769 Regulation TNF TLR1 17998391 1547776 Regulation TNF TLR1 18411340 1550366 Regulation TNF TLR1 18493310 2389292 Regulation TNF TLR1 18584038 3072600 Regulation TNF TLR1 18584038 3073171 Regulation TNF TLR1 19386086 242380 Regulation TNF TLR1 19386086 242400 Regulation TNF TLR1 19386086 242428 Regulation TNF TLR1 19667063 1555779 Regulation TNF TLR1 19668221 1952755 Regulation TNF TLR1 19770272 1556366 Regulation TNF TLR1 20584912 1377124 Regulation TNF TLR1 21049294 665227 Regulation TNF TLR1 21789039 979923 Regulation TNF TLR1 21829730 2542589 Regulation TNF TLR1 21852947 3052897 Regulation TNF TLR1 21861860 123682 Regulation TNF TLR1 21915309 2553196 Regulation TNF TLR1 22484733 1957138 Regulation TNF TLR1 22808181 2665045 Regulation TNF TLR1 22829768 3058192 Regulation TNF TLR1 22883744 1664730 Regulation TNF TLR1 22916150 2680080 Regulation TNF TLR1 23071254 1569686 Regulation TNF TLR1 23239947 3229374 Regulation TNF TLR1 23959031 3217819 Regulation TNF TLR1 24098413 2856270 Regulation TNF TLR1 24098508 2857853 Regulation TNF TLR1 24282429 639165 Regulation TNF TLR1 24734221 865083 Regulation TNF TLR1 25071732 927030 Regulation TNF TLR1 25078879 660738 Regulation TNF TLR1 25120287 1760459 Regulation TNF TLR1 25329467 3016114 Regulation TNF TLR10 16061725 1536980 Regulation TNF TLR10 17485511 1545659 Regulation TNF TLR10 17485512 1545801 Regulation TNF TLR10 17485512 1545908 Regulation TNF TLR10 17895997 2378777 Regulation TNF TLR10 17998391 1547784 Regulation TNF TLR10 18411340 1550374 Regulation TNF TLR10 18493310 2389300 Regulation TNF TLR10 18584038 3072608 Regulation TNF TLR10 18584038 3073179 Regulation TNF TLR10 19386086 242388 Regulation TNF TLR10 19386086 242408 Regulation TNF TLR10 19386086 242436 Regulation TNF TLR10 19667063 1555787 Regulation TNF TLR10 19668221 1952763 Regulation TNF TLR10 19770272 1556374 Regulation TNF TLR10 20584912 1377132 Regulation TNF TLR10 21049294 665235 Regulation TNF TLR10 21789039 979931 Regulation TNF TLR10 21829730 2542597 Regulation TNF TLR10 21852947 3052905 Regulation TNF TLR10 21861860 123690 Regulation TNF TLR10 21915309 2553204 Regulation TNF TLR10 22484733 1957146 Regulation TNF TLR10 22808181 2665053 Regulation TNF TLR10 22829768 3058201 Regulation TNF TLR10 22883744 1664738 Regulation TNF TLR10 22916150 2680088 Regulation TNF TLR10 23071254 1569694 Regulation TNF TLR10 23239947 3229382 Regulation TNF TLR10 23959031 3217827 Regulation TNF TLR10 24098413 2856278 Regulation TNF TLR10 24098508 2857861 Regulation TNF TLR10 24282429 639173 Regulation TNF TLR10 24734221 865091 Regulation TNF TLR10 25071732 927038 Regulation TNF TLR10 25078879 660746 Regulation TNF TLR10 25120287 1760467 Regulation TNF TLR10 25329467 3016122 Regulation TNF TLR2 16061725 1536973 Regulation TNF TLR2 16344862 3039081 Regulation TNF TLR2 16365150 1538970 Regulation TNF TLR2 17485511 1545652 Regulation TNF TLR2 17485511 1545739 Regulation TNF TLR2 17485512 1545794 Regulation TNF TLR2 17485512 1545901 Regulation TNF TLR2 17895997 2378770 Regulation TNF TLR2 17998391 1547777 Regulation TNF TLR2 17998391 1547797 Regulation TNF TLR2 18411340 1550367 Regulation TNF TLR2 18493310 2389293 Regulation TNF TLR2 18584038 3072601 Regulation TNF TLR2 18584038 3073172 Regulation TNF TLR2 19386086 242381 Regulation TNF TLR2 19386086 242401 Regulation TNF TLR2 19386086 242414 Regulation TNF TLR2 19386086 242429 Regulation TNF TLR2 19667063 1555780 Regulation TNF TLR2 19668221 1952756 Regulation TNF TLR2 19770272 1556367 Regulation TNF TLR2 19847289 2429170 Regulation TNF TLR2 20396387 1214875 Regulation TNF TLR2 20584912 1377125 Regulation TNF TLR2 20950462 356972 Regulation TNF TLR2 21049294 665228 Regulation TNF TLR2 21789039 979924 Regulation TNF TLR2 21829730 2542590 Regulation TNF TLR2 21852947 3052898 Regulation TNF TLR2 21861860 123683 Regulation TNF TLR2 21915309 2553197 Regulation TNF TLR2 22194732 923873 Regulation TNF TLR2 22417709 125113 Regulation TNF TLR2 22417709 125221 Regulation TNF TLR2 22434667 1050242 Regulation TNF TLR2 22434667 1050245 Regulation TNF TLR2 22454775 506851 Regulation TNF TLR2 22470546 2614557 Regulation TNF TLR2 22484733 1957139 Regulation TNF TLR2 22728440 3079596 Regulation TNF TLR2 22808181 2665018 Regulation TNF TLR2 22808181 2665046 Regulation TNF TLR2 22829768 3058193 Regulation TNF TLR2 22883744 1664731 Regulation TNF TLR2 22916150 2680081 Regulation TNF TLR2 22967304 1768263 Regulation TNF TLR2 23071254 1569687 Regulation TNF TLR2 23176969 3179398 Regulation TNF TLR2 23239947 3229375 Regulation TNF TLR2 23650544 2788937 Regulation TNF TLR2 23650544 2788938 Regulation TNF TLR2 23762102 819853 Regulation TNF TLR2 23805193 2807622 Regulation TNF TLR2 23959031 3217820 Regulation TNF TLR2 24098413 2856271 Regulation TNF TLR2 24098413 2856281 Regulation TNF TLR2 24098508 2857854 Regulation TNF TLR2 24282429 639166 Regulation TNF TLR2 24290283 1156632 Regulation TNF TLR2 24341851 346166 Regulation TNF TLR2 24734221 865084 Regulation TNF TLR2 24757287 1758246 Regulation TNF TLR2 24886142 368281 Regulation TNF TLR2 24983999 2986010 Regulation TNF TLR2 25053922 1627935 Regulation TNF TLR2 25057505 1622619 Regulation TNF TLR2 25071732 927031 Regulation TNF TLR2 25078879 660739 Regulation TNF TLR2 25120287 1760460 Regulation TNF TLR2 25329467 3016115 Regulation TNF TLR2 25400920 1037333 Regulation TNF TLR2 25436906 3030695 Regulation TNF TLR2 25595212 3211312 Regulation TNF TLR3 16061725 1536974 Regulation TNF TLR3 17485511 1545653 Regulation TNF TLR3 17485512 1545795 Regulation TNF TLR3 17485512 1545902 Regulation TNF TLR3 17895997 2378771 Regulation TNF TLR3 17998391 1547778 Regulation TNF TLR3 18411340 1550368 Regulation TNF TLR3 18493310 2389294 Regulation TNF TLR3 18584038 3072602 Regulation TNF TLR3 18584038 3073173 Regulation TNF TLR3 19088911 2214857 Regulation TNF TLR3 19386086 242382 Regulation TNF TLR3 19386086 242402 Regulation TNF TLR3 19386086 242430 Regulation TNF TLR3 19667063 1555781 Regulation TNF TLR3 19668221 1952757 Regulation TNF TLR3 19770272 1556368 Regulation TNF TLR3 20396387 1214876 Regulation TNF TLR3 20584912 1377126 Regulation TNF TLR3 21049294 665229 Regulation TNF TLR3 21789039 979925 Regulation TNF TLR3 21829730 2542591 Regulation TNF TLR3 21852947 3052899 Regulation TNF TLR3 21861860 123684 Regulation TNF TLR3 21915309 2553198 Regulation TNF TLR3 22484733 1957140 Regulation TNF TLR3 22661952 957410 Regulation TNF TLR3 22808181 2665047 Regulation TNF TLR3 22829768 3058194 Regulation TNF TLR3 22883744 1664732 Regulation TNF TLR3 22916150 2680082 Regulation TNF TLR3 23071254 1569688 Regulation TNF TLR3 23239947 3229376 Regulation TNF TLR3 23787171 1666858 Regulation TNF TLR3 23959031 3217821 Regulation TNF TLR3 24098413 2856272 Regulation TNF TLR3 24098508 2857855 Regulation TNF TLR3 24282429 639167 Regulation TNF TLR3 24734221 865085 Regulation TNF TLR3 24762979 2372605 Regulation TNF TLR3 25071732 927032 Regulation TNF TLR3 25078879 660740 Regulation TNF TLR3 25120287 1760461 Regulation TNF TLR3 25329467 3016116 Regulation TNF TLR3 25595212 3211313 Regulation TNF TLR4 11781369 1522142 Regulation TNF TLR4 16061725 1536975 Regulation TNF TLR4 17242961 810104 Regulation TNF TLR4 17485511 1545654 Regulation TNF TLR4 17485512 1545796 Regulation TNF TLR4 17485512 1545903 Regulation TNF TLR4 17895997 2378772 Regulation TNF TLR4 17998391 1547779 Regulation TNF TLR4 18411340 1550369 Regulation TNF TLR4 18493310 2389295 Regulation TNF TLR4 18510752 1655525 Regulation TNF TLR4 18584038 3072603 Regulation TNF TLR4 18584038 3073174 Regulation TNF TLR4 19196461 324776 Regulation TNF TLR4 19386086 242383 Regulation TNF TLR4 19386086 242403 Regulation TNF TLR4 19386086 242431 Regulation TNF TLR4 19667063 1555782 Regulation TNF TLR4 19668221 1952758 Regulation TNF TLR4 19675137 710816 Regulation TNF TLR4 19675137 710822 Regulation TNF TLR4 19770272 1556369 Regulation TNF TLR4 20584912 1377127 Regulation TNF TLR4 20827416 1049600 Regulation TNF TLR4 21049294 665230 Regulation TNF TLR4 21556316 1078181 Regulation TNF TLR4 21603190 22869 Regulation TNF TLR4 21789039 979926 Regulation TNF TLR4 21829730 2542592 Regulation TNF TLR4 21852947 3052900 Regulation TNF TLR4 21861860 123685 Regulation TNF TLR4 21915309 2553199 Regulation TNF TLR4 22322306 834290 Regulation TNF TLR4 22322306 834291 Regulation TNF TLR4 22434667 1050243 Regulation TNF TLR4 22484733 1957141 Regulation TNF TLR4 22563397 2626267 Regulation TNF TLR4 22655058 2646745 Regulation TNF TLR4 22661952 957411 Regulation TNF TLR4 22808181 2665019 Regulation TNF TLR4 22808181 2665048 Regulation TNF TLR4 22829768 3058195 Regulation TNF TLR4 22883744 1664733 Regulation TNF TLR4 22916150 2680083 Regulation TNF TLR4 22951730 1631222 Regulation TNF TLR4 22951730 1631372 Regulation TNF TLR4 23071254 1569689 Regulation TNF TLR4 23133376 3059969 Regulation TNF TLR4 23209806 2723165 Regulation TNF TLR4 23239947 3229377 Regulation TNF TLR4 23762102 819854 Regulation TNF TLR4 23864765 1754263 Regulation TNF TLR4 23936458 2831024 Regulation TNF TLR4 23959031 3217822 Regulation TNF TLR4 23984304 1072182 Regulation TNF TLR4 24098413 2856222 Regulation TNF TLR4 24098413 2856273 Regulation TNF TLR4 24098508 2857856 Regulation TNF TLR4 24165011 3123858 Regulation TNF TLR4 24282429 639168 Regulation TNF TLR4 24290283 1156633 Regulation TNF TLR4 24335753 3186512 Regulation TNF TLR4 24489448 1757434 Regulation TNF TLR4 24595131 2930810 Regulation TNF TLR4 24734221 865086 Regulation TNF TLR4 25053922 1627936 Regulation TNF TLR4 25071732 927033 Regulation TNF TLR4 25078879 660741 Regulation TNF TLR4 25120287 1760462 Regulation TNF TLR4 25329467 3016117 Regulation TNF TLR4 25566447 1498426 Regulation TNF TLR4 25580138 1703335 Regulation TNF TLR4 PMC4212304 3206243 Regulation TNF TLR5 16061725 1536976 Regulation TNF TLR5 17485511 1545655 Regulation TNF TLR5 17485512 1545797 Regulation TNF TLR5 17485512 1545904 Regulation TNF TLR5 17895997 2378773 Regulation TNF TLR5 17998391 1547780 Regulation TNF TLR5 18411340 1550370 Regulation TNF TLR5 18493310 2389296 Regulation TNF TLR5 18584038 3072604 Regulation TNF TLR5 18584038 3073175 Regulation TNF TLR5 19386086 242384 Regulation TNF TLR5 19386086 242404 Regulation TNF TLR5 19386086 242432 Regulation TNF TLR5 19461888 3043879 Regulation TNF TLR5 19667063 1555783 Regulation TNF TLR5 19668221 1952759 Regulation TNF TLR5 19770272 1556370 Regulation TNF TLR5 20584912 1377128 Regulation TNF TLR5 21049294 665231 Regulation TNF TLR5 21789039 979927 Regulation TNF TLR5 21829730 2542593 Regulation TNF TLR5 21852947 3052901 Regulation TNF TLR5 21861860 123686 Regulation TNF TLR5 21915309 2553200 Regulation TNF TLR5 22484733 1957142 Regulation TNF TLR5 22808181 2665049 Regulation TNF TLR5 22829768 3058196 Regulation TNF TLR5 22883744 1664734 Regulation TNF TLR5 22916150 2680084 Regulation TNF TLR5 23071254 1569690 Regulation TNF TLR5 23239947 3229378 Regulation TNF TLR5 23959031 3217823 Regulation TNF TLR5 24098413 2856274 Regulation TNF TLR5 24098508 2857857 Regulation TNF TLR5 24282429 639169 Regulation TNF TLR5 24734221 865087 Regulation TNF TLR5 25071732 927034 Regulation TNF TLR5 25078879 660742 Regulation TNF TLR5 25120287 1760463 Regulation TNF TLR5 25329467 3016118 Regulation TNF TLR6 16061725 1536981 Regulation TNF TLR6 17485511 1545660 Regulation TNF TLR6 17485512 1545802 Regulation TNF TLR6 17485512 1545909 Regulation TNF TLR6 17895997 2378778 Regulation TNF TLR6 17998391 1547785 Regulation TNF TLR6 18411340 1550375 Regulation TNF TLR6 18493310 2389301 Regulation TNF TLR6 18584038 3072609 Regulation TNF TLR6 18584038 3073180 Regulation TNF TLR6 19386086 242389 Regulation TNF TLR6 19386086 242409 Regulation TNF TLR6 19386086 242437 Regulation TNF TLR6 19667063 1555788 Regulation TNF TLR6 19668221 1952764 Regulation TNF TLR6 19770272 1556375 Regulation TNF TLR6 20584912 1377133 Regulation TNF TLR6 21049294 665236 Regulation TNF TLR6 21789039 979932 Regulation TNF TLR6 21829730 2542598 Regulation TNF TLR6 21852947 3052906 Regulation TNF TLR6 21861860 123691 Regulation TNF TLR6 21915309 2553205 Regulation TNF TLR6 22484733 1957147 Regulation TNF TLR6 22808181 2665054 Regulation TNF TLR6 22829768 3058202 Regulation TNF TLR6 22883744 1664739 Regulation TNF TLR6 22916150 2680089 Regulation TNF TLR6 23071254 1569695 Regulation TNF TLR6 23239947 3229383 Regulation TNF TLR6 23959031 3217828 Regulation TNF TLR6 24098413 2856279 Regulation TNF TLR6 24098508 2857862 Regulation TNF TLR6 24282429 639174 Regulation TNF TLR6 24734221 865092 Regulation TNF TLR6 24983999 2986011 Regulation TNF TLR6 25071732 927039 Regulation TNF TLR6 25078879 660747 Regulation TNF TLR6 25120287 1760468 Regulation TNF TLR6 25329467 3016123 Regulation TNF TLR7 16061725 1536977 Regulation TNF TLR7 17485511 1545656 Regulation TNF TLR7 17485512 1545798 Regulation TNF TLR7 17485512 1545905 Regulation TNF TLR7 17895997 2378774 Regulation TNF TLR7 17998391 1547781 Regulation TNF TLR7 18411340 1550371 Regulation TNF TLR7 18493310 2389297 Regulation TNF TLR7 18584038 3072605 Regulation TNF TLR7 18584038 3073176 Regulation TNF TLR7 19386086 242385 Regulation TNF TLR7 19386086 242405 Regulation TNF TLR7 19386086 242433 Regulation TNF TLR7 19424421 3043795 Regulation TNF TLR7 19667063 1555784 Regulation TNF TLR7 19668221 1952760 Regulation TNF TLR7 19770272 1556371 Regulation TNF TLR7 20584912 1377129 Regulation TNF TLR7 21049294 665232 Regulation TNF TLR7 21115688 1562051 Regulation TNF TLR7 21115688 1562063 Regulation TNF TLR7 21789039 979928 Regulation TNF TLR7 21829730 2542594 Regulation TNF TLR7 21852947 3052902 Regulation TNF TLR7 21861860 123687 Regulation TNF TLR7 21915309 2553201 Regulation TNF TLR7 22484733 1957143 Regulation TNF TLR7 22530722 3210219 Regulation TNF TLR7 22606294 2643007 Regulation TNF TLR7 22808181 2665050 Regulation TNF TLR7 22829768 3058198 Regulation TNF TLR7 22883744 1664735 Regulation TNF TLR7 22916150 2680085 Regulation TNF TLR7 23071254 1569691 Regulation TNF TLR7 23239947 3229379 Regulation TNF TLR7 23396449 2085553 Regulation TNF TLR7 23959031 3217824 Regulation TNF TLR7 24098413 2856275 Regulation TNF TLR7 24098508 2857858 Regulation TNF TLR7 24282429 639170 Regulation TNF TLR7 24734221 865088 Regulation TNF TLR7 25071732 927035 Regulation TNF TLR7 25078879 660743 Regulation TNF TLR7 25120287 1760464 Regulation TNF TLR7 25329467 3016119 Regulation TNF TLR7 25485543 3032615 Regulation TNF TLR8 16061725 1536978 Regulation TNF TLR8 17485511 1545657 Regulation TNF TLR8 17485512 1545799 Regulation TNF TLR8 17485512 1545906 Regulation TNF TLR8 17895997 2378775 Regulation TNF TLR8 17998391 1547782 Regulation TNF TLR8 18411340 1550372 Regulation TNF TLR8 18493310 2389298 Regulation TNF TLR8 18584038 3072606 Regulation TNF TLR8 18584038 3073177 Regulation TNF TLR8 19386086 242386 Regulation TNF TLR8 19386086 242406 Regulation TNF TLR8 19386086 242434 Regulation TNF TLR8 19667063 1555785 Regulation TNF TLR8 19668221 1952761 Regulation TNF TLR8 19770272 1556372 Regulation TNF TLR8 20584912 1377130 Regulation TNF TLR8 21049294 665233 Regulation TNF TLR8 21789039 979929 Regulation TNF TLR8 21829730 2542595 Regulation TNF TLR8 21852947 3052903 Regulation TNF TLR8 21861860 123688 Regulation TNF TLR8 21915309 2553202 Regulation TNF TLR8 22484733 1957144 Regulation TNF TLR8 22808181 2665051 Regulation TNF TLR8 22829768 3058199 Regulation TNF TLR8 22883744 1664736 Regulation TNF TLR8 22916150 2680086 Regulation TNF TLR8 23071254 1569692 Regulation TNF TLR8 23239947 3229380 Regulation TNF TLR8 23959031 3217825 Regulation TNF TLR8 24098413 2856276 Regulation TNF TLR8 24098508 2857859 Regulation TNF TLR8 24282429 639171 Regulation TNF TLR8 24734221 865089 Regulation TNF TLR8 25071732 927036 Regulation TNF TLR8 25078879 660744 Regulation TNF TLR8 25120287 1760465 Regulation TNF TLR8 25329467 3016120 Regulation TNF TLR9 15197227 1532927 Regulation TNF TLR9 15197227 1532972 Regulation TNF TLR9 16061725 1536979 Regulation TNF TLR9 17485511 1545658 Regulation TNF TLR9 17485512 1545800 Regulation TNF TLR9 17485512 1545907 Regulation TNF TLR9 17895997 2378776 Regulation TNF TLR9 17998391 1547783 Regulation TNF TLR9 18411340 1550373 Regulation TNF TLR9 18493310 2389299 Regulation TNF TLR9 18584038 3072607 Regulation TNF TLR9 18584038 3073178 Regulation TNF TLR9 19386086 242387 Regulation TNF TLR9 19386086 242407 Regulation TNF TLR9 19386086 242415 Regulation TNF TLR9 19386086 242435 Regulation TNF TLR9 19667063 1555786 Regulation TNF TLR9 19668221 1952762 Regulation TNF TLR9 19770272 1556373 Regulation TNF TLR9 20584912 1377131 Regulation TNF TLR9 21049294 665234 Regulation TNF TLR9 21115688 1562052 Regulation TNF TLR9 21115691 1562138 Regulation TNF TLR9 21115691 1562149 Regulation TNF TLR9 21789039 979930 Regulation TNF TLR9 21829730 2542596 Regulation TNF TLR9 21852947 3052904 Regulation TNF TLR9 21861860 123689 Regulation TNF TLR9 21915309 2553203 Regulation TNF TLR9 22484733 1957145 Regulation TNF TLR9 22719247 3057134 Regulation TNF TLR9 22808181 2665052 Regulation TNF TLR9 22829768 3058200 Regulation TNF TLR9 22883744 1664737 Regulation TNF TLR9 22916150 2680087 Regulation TNF TLR9 23071254 1569693 Regulation TNF TLR9 23239947 3229381 Regulation TNF TLR9 23396449 2085554 Regulation TNF TLR9 23452377 356212 Regulation TNF TLR9 23650544 2788935 Regulation TNF TLR9 23650544 2788939 Regulation TNF TLR9 23959031 3217826 Regulation TNF TLR9 24098413 2856277 Regulation TNF TLR9 24098508 2857860 Regulation TNF TLR9 24282429 639172 Regulation TNF TLR9 24498172 2918810 Regulation TNF TLR9 24734221 865090 Regulation TNF TLR9 25071732 927037 Regulation TNF TLR9 25078879 660745 Regulation TNF TLR9 25120287 1760466 Regulation TNF TLR9 25329467 3016121 Regulation TNF TNFAIP3 24747594 1126209 Regulation TNF TNFAIP6 25088370 1668376 Regulation TNF TNFRSF1A 18250193 1548974 Regulation TNF TNFRSF1A 19421420 979112 Regulation TNF TNFRSF1A 19893201 736358 Regulation TNF TNFRSF1A 24949443 192678 Regulation TNF TNFRSF1B 19506728 671650 Regulation TNF TNFRSF1B 19506728 671652 Regulation TNF TNFRSF1B 21754991 2535259 Regulation TNF TNFRSF1B 22844580 3131094 Regulation TNF TNFRSF1B 23469058 2760940 Regulation TNF TNFRSF1B 23469058 2760944 Regulation TNF TNFRSF1B 23874808 2822922 Regulation TNF TNFRSF1B 24776599 514461 Regulation TNF TNFRSF1B 24861337 653714 Regulation TNF TNFRSF9 21747409 1041756 Regulation TNF TNFRSF9 22039370 1038367 Regulation TNF TNFRSF9 22039370 1038388 Regulation TNF TNFRSF9 23437083 2755517 Regulation TNF TNFRSF9 23437083 2755518 Regulation TNF TNFSF11 17634140 108561 Regulation TNF TNP1 19124655 1553363 Regulation TNF TNP2 19124655 1553364 Regulation TNF TOLLIP 19198660 2405464 Regulation TNF TOP2A 22027829 1193618 Regulation TNF TP53 18558008 323724 Regulation TNF TP53 22973314 1068891 Regulation TNF TPPP 20824074 2473610 Regulation TNF TRAF2 21119000 1783899 Regulation TNF TRAF6 22496647 3056093 Regulation TNF TREM2 22666624 1052908 Regulation TNF TRIM21 23737876 843241 Regulation TNF TRIM21 23737876 843242 Regulation TNF TRIM3 23967238 2835176 Regulation TNF TRIM8 23152791 2716285 Regulation TNF TSC22D3 22396737 2608463 Regulation TNF TSPAN31 23758654 3210512 Regulation TNF TXNIP 23820201 1704179 Regulation TNF TYR 23445687 294240 Regulation TNF UBA6 23883607 363908 Regulation TNF UBE2N 20613989 2454657 Regulation TNF UGCG 15857511 648871 Regulation TNF USP12 25071782 913476 Regulation TNF USP25 23042150 1957883 Regulation TNF USP5 24349023 2896634 Regulation TNF UXT 21307340 1786589 Regulation TNF UXT 21307340 1786598 Regulation TNF VEGFA 2258694 1568154 Regulation TNF VIMP 23634235 2225811 Regulation TNF VIMP 23634235 2225818 Regulation TNF VIP 14680506 99976 Regulation TNF VIP 14680506 99978 Regulation TNF VIP 14680506 100010 Regulation TNF VIP 15899028 102737 Regulation TNF WAS 24009860 203998 Regulation TNF WDR61 14580106 3228348 Regulation TNF WNT1 24286133 130201 Regulation TNF WNT1 24286133 130202 Regulation TNF WNT1 24286133 130203 Regulation TNF WNT1 24286133 130271 Regulation TNF WNT1 24286133 130369 Regulation TNF WNT1 24286133 130387 Regulation TNF WNT11 24286133 130204 Regulation TNF WNT11 24286133 130205 Regulation TNF WNT11 24286133 130206 Regulation TNF WNT11 24286133 130272 Regulation TNF WNT11 24286133 130370 Regulation TNF WNT11 24286133 130388 Regulation TNF WNT16 24286133 130219 Regulation TNF WNT16 24286133 130220 Regulation TNF WNT16 24286133 130221 Regulation TNF WNT16 24286133 130277 Regulation TNF WNT16 24286133 130376 Regulation TNF WNT16 24286133 130393 Regulation TNF WNT2 24286133 130207 Regulation TNF WNT2 24286133 130208 Regulation TNF WNT2 24286133 130209 Regulation TNF WNT2 24286133 130273 Regulation TNF WNT2 24286133 130371 Regulation TNF WNT2 24286133 130389 Regulation TNF WNT3 24286133 130210 Regulation TNF WNT3 24286133 130211 Regulation TNF WNT3 24286133 130212 Regulation TNF WNT3 24286133 130274 Regulation TNF WNT3 24286133 130372 Regulation TNF WNT3 24286133 130390 Regulation TNF WNT4 24286133 130213 Regulation TNF WNT4 24286133 130214 Regulation TNF WNT4 24286133 130215 Regulation TNF WNT4 24286133 130275 Regulation TNF WNT4 24286133 130373 Regulation TNF WNT4 24286133 130391 Regulation TNF WNT5A 24993819 274224 Regulation TNF WNT6 24286133 130216 Regulation TNF WNT6 24286133 130217 Regulation TNF WNT6 24286133 130218 Regulation TNF WNT6 24286133 130276 Regulation TNF WNT6 24286133 130374 Regulation TNF WNT6 24286133 130392 Regulation TNF WWP1 23799152 2807356 Regulation TNF WWP1 23799152 2807357 Regulation TNF YWHAB 21871121 1659638 Regulation TNF ZFP36 14638848 1529853 Regulation TNF ZFP36 14638848 1529854 Regulation TNF ZFP36 14638848 1529905 Regulation TNF ZFP36 15535838 101911 Regulation TNF ZFP36 20221403 2442564 Regulation TNF ZFP36 21611196 2523836 Regulation TNF ZFP36 23028373 2338482 Regulation TNF ZFP36 23468959 2760285 Regulation TNF ZFP36 23468959 2760288 Regulation TNF ZFP36 23468959 2760289 Regulation TNF ZFP36 23468959 2760295 Regulation TNF ZFP36 23940256 1573395 Regulation TNF ZFP36 24069363 2853131 Regulation TNF ZFP36 PMC2834070 134563 Regulation TNF ZFYVE9 23435238 3222298 Regulation TNFAIP3 TNF 17052335 319218 Regulation TNFAIP3 TNF 24489933 2916749 Regulation TNFAIP3 TNF 24489933 2916902 Regulation TNFAIP3 TNF 24489933 2916903 Regulation TNFAIP3 TNF 25071782 913483 Regulation TNFAIP6 TNF 12823853 99846 Regulation TNFAIP6 TNF 22455445 336082 Regulation TNFRSF10A TNF 20440001 1376091 Regulation TNFRSF10A TNFSF10 21209944 2492476 Regulation TNFRSF10B MUC16 24690311 272600 Regulation TNFRSF10B TNFSF10 21209944 2492477 Regulation TNFRSF11B EPHB2 24265865 206072 Regulation TNFRSF11B TGM2 24265865 206059 Regulation TNFRSF11B TGM2 24265865 206060 Regulation TNFRSF11B TGM2 24265865 206061 Regulation TNFRSF11B TGM2 24265865 206075 Regulation TNFRSF11B TGM2 24265865 206081 Regulation TNFRSF11B TGM2 24265865 206082 Regulation TNFRSF11B TGM2 24265865 206084 Regulation TNFRSF11B TNF 15142264 101178 Regulation TNFRSF11B TNF 15642135 102293 Regulation TNFRSF11B TNF 15642135 102297 Regulation TNFRSF11B TNF 15642135 102300 Regulation TNFRSF11B TNF 17963332 3231332 Regulation TNFRSF11B TNF 17963332 3231333 Regulation TNFRSF11B TNF 17963332 3231369 Regulation TNFRSF11B TNF 24228244 184963 Regulation TNFRSF11B TNF 24592264 911244 Regulation TNFRSF11B TNF 24683547 187708 Regulation TNFRSF11B TNF PMC2833857 134396 Regulation TNFRSF11B TNF PMC2834080 134568 Regulation TNFRSF13C TLR7 21818370 2540744 Regulation TNFRSF1A TNF 16385659 3230830 Regulation TNFRSF1A TNF 16385659 3230831 Regulation TNFRSF1A TNF 19421420 979113 Regulation TNFRSF1A TNF 21754991 2535245 Regulation TNFRSF1A TNF 21789261 2538371 Regulation TNFRSF1A TNF 24083053 3175373 Regulation TNFRSF1A TNF 24098720 2859479 Regulation TNFRSF1A TNF 24502696 1233308 Regulation TNFRSF1A TNF 25140115 1760940 Regulation TNFRSF1A TNF 25140115 1760941 Regulation TNFRSF1A TNF 25228904 914156 Regulation TNFRSF1A TNF 25228904 914180 Regulation TNFRSF1B CHI3L1 7519240 1589379 Regulation TNFRSF1B TNF 16385659 3230833 Regulation TNFRSF1B TNF 19506728 671653 Regulation TNFRSF1B TNF 21754991 2535246 Regulation TNFRSF1B TNF 24626175 2933957 Regulation TNFRSF1B TNF 25228904 914158 Regulation TNFRSF1B TNF 25228904 914182 Regulation TNFRSF9 TNF 22039370 1038369 Regulation TNFSF10 AKT1 22159760 2170485 Regulation TNFSF10 AKT2 22159760 2170486 Regulation TNFSF10 AKT3 22159760 2170487 Regulation TNFSF10 BAX 17718901 1645607 Regulation TNFSF10 BIRC2 18606850 1353517 Regulation TNFSF10 BIRC2 24633224 2934765 Regulation TNFSF10 CASP1 22048166 553299 Regulation TNFSF10 CASP1 22048166 553300 Regulation TNFSF10 CASP1 23254290 558405 Regulation TNFSF10 CASP10 22048166 553301 Regulation TNFSF10 CASP10 22048166 553302 Regulation TNFSF10 CASP10 23254290 558406 Regulation TNFSF10 CASP12 22048166 553321 Regulation TNFSF10 CASP12 22048166 553322 Regulation TNFSF10 CASP12 23254290 558416 Regulation TNFSF10 CASP14 22048166 553303 Regulation TNFSF10 CASP14 22048166 553304 Regulation TNFSF10 CASP14 23254290 558407 Regulation TNFSF10 CASP16 22048166 553323 Regulation TNFSF10 CASP16 22048166 553324 Regulation TNFSF10 CASP16 23254290 558417 Regulation TNFSF10 CASP2 22048166 553305 Regulation TNFSF10 CASP2 22048166 553306 Regulation TNFSF10 CASP2 23254290 558408 Regulation TNFSF10 CASP3 21237154 828991 Regulation TNFSF10 CASP3 22048166 553307 Regulation TNFSF10 CASP3 22048166 553308 Regulation TNFSF10 CASP3 23254290 558409 Regulation TNFSF10 CASP4 22048166 553309 Regulation TNFSF10 CASP4 22048166 553310 Regulation TNFSF10 CASP4 23254290 558410 Regulation TNFSF10 CASP5 22048166 553311 Regulation TNFSF10 CASP5 22048166 553312 Regulation TNFSF10 CASP5 23254290 558411 Regulation TNFSF10 CASP6 22048166 553313 Regulation TNFSF10 CASP6 22048166 553314 Regulation TNFSF10 CASP6 23254290 558412 Regulation TNFSF10 CASP7 22048166 553315 Regulation TNFSF10 CASP7 22048166 553316 Regulation TNFSF10 CASP7 23254290 558413 Regulation TNFSF10 CASP8 16434995 426980 Regulation TNFSF10 CASP8 20967281 2478630 Regulation TNFSF10 CASP8 22048166 553317 Regulation TNFSF10 CASP8 22048166 553318 Regulation TNFSF10 CASP8 23254290 558414 Regulation TNFSF10 CASP9 22048166 553319 Regulation TNFSF10 CASP9 22048166 553320 Regulation TNFSF10 CASP9 23254290 558415 Regulation TNFSF10 CD28 10224285 1511683 Regulation TNFSF10 CD3D 10224285 1511684 Regulation TNFSF10 CD3D 10224285 1511685 Regulation TNFSF10 CD3E 10224285 1511686 Regulation TNFSF10 CD3E 10224285 1511687 Regulation TNFSF10 CD3G 10224285 1511688 Regulation TNFSF10 CD3G 10224285 1511689 Regulation TNFSF10 CD40 25505620 2248744 Regulation TNFSF10 CD70 24481449 571790 Regulation TNFSF10 CDH13 24244613 2880952 Regulation TNFSF10 CFLAR 22348197 497096 Regulation TNFSF10 CFLAR 25379355 1243454 Regulation TNFSF10 CRK 20877355 435994 Regulation TNFSF10 DDX58 22087337 2571547 Regulation TNFSF10 DDX58 22087337 2571548 Regulation TNFSF10 DDX58 22087337 2571550 Regulation TNFSF10 DDX58 22087337 2571552 Regulation TNFSF10 DDX58 24369016 185975 Regulation TNFSF10 FAS 20967287 2370822 Regulation TNFSF10 FOXO3 22159760 2170484 Regulation TNFSF10 FOXO3 22159760 2170507 Regulation TNFSF10 FOXO3 23828551 2183516 Regulation TNFSF10 GIF PMC4220873 357760 Regulation TNFSF10 GLMN 25313680 2288242 Regulation TNFSF10 GRAP2 23514593 3121481 Regulation TNFSF10 HDAC2 20398369 1853928 Regulation TNFSF10 HLA-DRB1 20087343 434321 Regulation TNFSF10 HMGB1 PMC4220873 357761 Regulation TNFSF10 HRAS 23470485 2182453 Regulation TNFSF10 IFN1@ 24455433 3151159 Regulation TNFSF10 IFNAR1 23468627 3060374 Regulation TNFSF10 IL10 21187913 3050256 Regulation TNFSF10 IL10 21187913 3050257 Regulation TNFSF10 IL12A 22520731 1230551 Regulation TNFSF10 IL12B 22520731 1230552 Regulation TNFSF10 IL18 PMC2833857 134381 Regulation TNFSF10 IRF1 19404407 2415740 Regulation TNFSF10 IRF1 19404407 2415774 Regulation TNFSF10 IRF1 19404407 2415775 Regulation TNFSF10 IRF3 21829705 2542479 Regulation TNFSF10 IRF3 21829705 2542484 Regulation TNFSF10 IRF7 19404407 2415776 Regulation TNFSF10 KRAS 23470485 2182454 Regulation TNFSF10 KRR1 23096115 557875 Regulation TNFSF10 KRR1 23096115 557895 Regulation TNFSF10 LBH 20442774 2448907 Regulation TNFSF10 LGALS3 19308684 495156 Regulation TNFSF10 MADD 21915099 770794 Regulation TNFSF10 MAPK1 23514593 3121482 Regulation TNFSF10 MAPK10 23514593 3121483 Regulation TNFSF10 MAPK11 23514593 3121484 Regulation TNFSF10 MAPK12 23514593 3121485 Regulation TNFSF10 MAPK13 23514593 3121486 Regulation TNFSF10 MAPK14 23514593 3121487 Regulation TNFSF10 MAPK15 23514593 3121480 Regulation TNFSF10 MAPK3 22279582 2590814 Regulation TNFSF10 MAPK3 23514593 3121488 Regulation TNFSF10 MAPK4 23514593 3121489 Regulation TNFSF10 MAPK6 23514593 3121490 Regulation TNFSF10 MAPK7 23514593 3121491 Regulation TNFSF10 MAPK8 22279582 2590815 Regulation TNFSF10 MAPK8 23514593 3121492 Regulation TNFSF10 MAPK9 23514593 3121493 Regulation TNFSF10 MAVS 24369016 185976 Regulation TNFSF10 MET 24748276 2956031 Regulation TNFSF10 MET 24748276 2956060 Regulation TNFSF10 MET 24748276 2956062 Regulation TNFSF10 MLKL 23835476 611280 Regulation TNFSF10 MUC16 24690311 272536 Regulation TNFSF10 MYLIP 24941171 2980828 Regulation TNFSF10 NFATC1 21603612 2523447 Regulation TNFSF10 NFATC1 21603612 2523467 Regulation TNFSF10 NFATC1 21603612 2523493 Regulation TNFSF10 NFATC1 21603612 2523505 Regulation TNFSF10 NFATC1 21603612 2523510 Regulation TNFSF10 NFATC1 22696685 1804020 Regulation TNFSF10 NFATC2 21603612 2523506 Regulation TNFSF10 NFATC2IP 23170112 842642 Regulation TNFSF10 NFATC3 21603612 2523468 Regulation TNFSF10 NFATC4 21603612 2523469 Regulation TNFSF10 NOX4 22048166 553428 Regulation TNFSF10 NRAS 23470485 2182455 Regulation TNFSF10 PDGFRB 24999473 194212 Regulation TNFSF10 SP1 21603612 2523446 Regulation TNFSF10 SP1 21603612 2523478 Regulation TNFSF10 SP1 21603612 2523490 Regulation TNFSF10 SP1 21603612 2523492 Regulation TNFSF10 SP1 22892844 478736 Regulation TNFSF10 SP1 22892844 478759 Regulation TNFSF10 SP1 22892844 478768 Regulation TNFSF10 SREBF1 21406729 2175631 Regulation TNFSF10 STAT1 19404407 2415773 Regulation TNFSF10 STAT3 23514593 3121479 Regulation TNFSF10 TANK 18606850 1353516 Regulation TNFSF10 TAT 21368875 550918 Regulation TNFSF10 TNF 21850048 552449 Regulation TNFSF10 TNF PMC2833857 134397 Regulation TNFSF10 TNFRSF10A 18504532 1644044 Regulation TNFSF10 TNFRSF10B 24324518 824429 Regulation TNFSF10 TNFSF11 23300516 2733580 Regulation TNFSF10 TP53 22745910 155222 Regulation TNFSF10 TP53 22892844 478741 Regulation TNFSF10 TRAF6 22719861 2653295 Regulation TNFSF10 TRNAE1 22530952 264522 Regulation TNFSF10 TYRP1 25358794 3167505 Regulation TNFSF11 MMP7 24665208 487655 Regulation TNFSF11 TNF 11805147 1522492 Regulation TNFSF11 TNF 17963332 3231334 Regulation TNFSF11 TNF 17963332 3231335 Regulation TNFSF11 TNF 17963332 3231371 Regulation TNFSF11 TNF 21410959 121897 Regulation TNFSF11 TNF 24592264 911245 Regulation TNFSF11 TNF 25228904 914160 Regulation TNFSF11 TNF PMC2833857 134398 Regulation TNFSF11 TNFSF10 23300516 2733581 Regulation TNFSF11 ZFP57 23569325 1571173 Regulation TNFSF11 ZFP57 23569325 1571286 Regulation TNFSF11 ZFP57 23569325 1571454 Regulation TNFSF12 TNF 11879548 98712 Regulation TNFSF12 TNFSF10 24130833 2867293 Regulation TNFSF13 MMP28 23383143 2748285 Regulation TNFSF13 MMP7 23383143 2748301 Regulation TNFSF13B TLR7 19291304 112967 Regulation TNFSF13B TLR7 21818370 2540740 Regulation TNFSF13B TLR7 21818370 2540741 Regulation TNFSF13B TLR7 21818370 2540742 Regulation TNFSF13B TLR7 21818370 2540743 Regulation TNFSF13B TLR7 21818370 2540754 Regulation TNFSF13B TLR7 24877127 192056 Regulation TNFSF13B TNF 19291304 112949 Regulation TNFSF15 TLR7 24876829 681772 Regulation TNMD EPHB2 23157718 3207808 Regulation TNNT2 MBNL1 18286170 2383574 Regulation TNNT2 MBNL1 18286170 2383575 Regulation TNNT2 MYBPC3 23233322 1243945 Regulation TNNT2 SLC25A20 23810896 1156992 Regulation TOLLIP SERPINA5 23148642 339568 Regulation TP53 ANKRD1 22016770 2562613 Regulation TP53 CCND1 10376986 414411 Regulation TP53 CCND1 22548705 1865877 Regulation TP53 CTGF 22438586 1801417 Regulation TP53 DAPK1 16476779 1327892 Regulation TP53 DAPK1 20145727 1065992 Regulation TP53 DAPK1 25229255 2200306 Regulation TP53 EPHB2 12676607 791644 Regulation TP53 EPHB2 18847491 251677 Regulation TP53 EPHB2 18847491 251680 Regulation TP53 EPHB2 23638878 1868124 Regulation TP53 EPHB2 23844043 2819131 Regulation TP53 EPHB2 25162007 197892 Regulation TP53 EPHB2 25162007 197912 Regulation TP53 EPHB2 25162007 197913 Regulation TP53 EPHB2 25196936 1730902 Regulation TP53 FAS 23166734 2718830 Regulation TP53 FAS 23166734 2718843 Regulation TP53 FAS 23166734 2718844 Regulation TP53 FAS 24622841 3081745 Regulation TP53 FAS 24980819 2194736 Regulation TP53 FHL1 22028589 1223119 Regulation TP53 FOXO1 20085646 236522 Regulation TP53 FOXO1 20878915 775197 Regulation TP53 HBEGF 23236372 2725998 Regulation TP53 HBEGF 23236372 2726020 Regulation TP53 JAG1 24098521 2858046 Regulation TP53 JAG1 24098521 2858061 Regulation TP53 JAG1 24098521 2858069 Regulation TP53 JAG1 24098521 2858075 Regulation TP53 LGALS7B 25277199 2203318 Regulation TP53 MAP2K6 15642743 1534181 Regulation TP53 OSR1 24931004 1681348 Regulation TP53 PLAU 23864708 1816992 Regulation TP53 PLAU 23864708 1817019 Regulation TP53 TNF 17567906 370641 Regulation TP53 TNF 18213398 804415 Regulation TP53 TNF 18521369 3127592 Regulation TP53 TNF 18521369 3127593 Regulation TP53 TNF 22039421 2565403 Regulation TP53 TNF 22973314 1068911 Regulation TP53 TNF 23193206 729944 Regulation TP53 TP63 22389628 2278519 Regulation TP53 WIF1 24853424 576270 Regulation TP63 ABL1 21364617 549353 Regulation TP63 BMP1 22662233 2647605 Regulation TP63 BMP10 22662233 2647613 Regulation TP63 BMP15 22662233 2647606 Regulation TP63 BMP2 22662233 2647607 Regulation TP63 BMP3 22662233 2647608 Regulation TP63 BMP4 22662233 2647609 Regulation TP63 BMP5 22662233 2647610 Regulation TP63 BMP6 22662233 2647611 Regulation TP63 BMP7 22662233 2647612 Regulation TP63 CCDC88A 15728240 1534745 Regulation TP63 CD40LG 23837669 128449 Regulation TP63 CDH1 23658742 2790136 Regulation TP63 CKAP4 22247000 777629 Regulation TP63 CRK 22073300 2569850 Regulation TP63 CSF2 10811870 1515482 Regulation TP63 ETS2 19047440 1553000 Regulation TP63 FGFR2 23545251 2182980 Regulation TP63 FOXN1 24594519 2929902 Regulation TP63 IGF1 23906066 700776 Regulation TP63 IGF1 23906066 700879 Regulation TP63 IL10 16365149 1538937 Regulation TP63 IL12A 9348310 1601841 Regulation TP63 IL12B 9348310 1601842 Regulation TP63 IL15 23509806 180553 Regulation TP63 IL2 21364747 2504211 Regulation TP63 IL4 10811870 1515483 Regulation TP63 INS 23906066 700777 Regulation TP63 IRF8 9348310 1601840 Regulation TP63 ITGA4 18802456 3041833 Regulation TP63 ITGA4 18802456 3041834 Regulation TP63 ITGA4 18802456 3041870 Regulation TP63 ITGB1 18802456 3041835 Regulation TP63 ITGB1 18802456 3041836 Regulation TP63 ITGB1 18802456 3041871 Regulation TP63 MYCN 24556696 572383 Regulation TP63 MYD88 16365150 1538975 Regulation TP63 MYLIP 23545251 2182979 Regulation TP63 NFIL3 24690414 132080 Regulation TP63 OPN1LW 21931552 3053415 Regulation TP63 PCBP1 23940783 2832407 Regulation TP63 PCBP1 23940783 2832414 Regulation TP63 PCBP1 23940783 2832423 Regulation TP63 PLK1 23948487 2184639 Regulation TP63 PRDX2 22073300 2569841 Regulation TP63 PSMB9 20498633 2132339 Regulation TP63 PSMB9 20498633 2132347 Regulation TP63 PSMB9 20498633 2132348 Regulation TP63 RABEPK 18847496 111634 Regulation TP63 TLR1 18584038 3072610 Regulation TP63 TLR1 18584038 3073211 Regulation TP63 TLR1 18584038 3073212 Regulation TP63 TLR10 18584038 3072618 Regulation TP63 TLR10 18584038 3073227 Regulation TP63 TLR10 18584038 3073228 Regulation TP63 TLR2 18584038 3072611 Regulation TP63 TLR2 18584038 3073213 Regulation TP63 TLR2 18584038 3073214 Regulation TP63 TLR3 18584038 3072612 Regulation TP63 TLR3 18584038 3073215 Regulation TP63 TLR3 18584038 3073216 Regulation TP63 TLR4 18584038 3072613 Regulation TP63 TLR4 18584038 3073217 Regulation TP63 TLR4 18584038 3073218 Regulation TP63 TLR4 21152080 2486110 Regulation TP63 TLR5 18584038 3072614 Regulation TP63 TLR5 18584038 3073219 Regulation TP63 TLR5 18584038 3073220 Regulation TP63 TLR6 18584038 3072619 Regulation TP63 TLR6 18584038 3073229 Regulation TP63 TLR6 18584038 3073230 Regulation TP63 TLR7 18584038 3072615 Regulation TP63 TLR7 18584038 3073221 Regulation TP63 TLR7 18584038 3073222 Regulation TP63 TLR7 21152080 2486111 Regulation TP63 TLR8 18584038 3072616 Regulation TP63 TLR8 18584038 3073223 Regulation TP63 TLR8 18584038 3073224 Regulation TP63 TLR9 18584038 3072617 Regulation TP63 TLR9 18584038 3073225 Regulation TP63 TLR9 18584038 3073226 Regulation TP63 TP53 24823795 2100820 Regulation TP63 TP53 24823795 2100821 Regulation TP63 TP53 24823795 2100838 Regulation TP63 VCAM1 18802456 3041831 Regulation TP63 VCAM1 18802456 3041832 Regulation TP63 VCAM1 18802456 3041869 Regulation TPM1 TMOD1 2380244 1405728 Regulation TPM1 TMOD1 2380244 1405729 Regulation TPM1 TMOD1 2380244 1405851 Regulation TPM2 TMOD1 2380244 1405736 Regulation TPM2 TMOD1 2380244 1405737 Regulation TPM2 TMOD1 2380244 1405855 Regulation TPM3 TMOD1 2380244 1405744 Regulation TPM3 TMOD1 2380244 1405745 Regulation TPM3 TMOD1 2380244 1405859 Regulation TPM4 TMOD1 2380244 1405752 Regulation TPM4 TMOD1 2380244 1405753 Regulation TPM4 TMOD1 2380244 1405863 Regulation TPX2 TNF 20967264 2478611 Regulation TRADD TNF 17567906 370597 Regulation TRADD TNF 23429285 560011 Regulation TRAF1 TNF 11696595 1521650 Regulation TRAF1 TNF 22679495 2650127 Regulation TRAF2 TNF 19918265 609849 Regulation TRAF2 TNF 19918265 609875 Regulation TRAF2 TNF 22679495 2650128 Regulation TRAF3 TNF 21078888 1561561 Regulation TRAF3 TNF 21078888 1561567 Regulation TRAF3 TNF 22679495 2650129 Regulation TRAF4 TNF 22679495 2650130 Regulation TRAF5 TNF 22679495 2650131 Regulation TRAF6 EPHB2 19305426 2124963 Regulation TRAF6 TLR7 18411340 1550438 Regulation TRAF6 TLR7 19668221 1952717 Regulation TRAF6 TLR7 19668221 1952770 Regulation TRAF6 TNF 22679495 2650132 Regulation TRAF7 TNF 22679495 2650133 Regulation TREM1 TLR7 24842612 2971805 Regulation TREM2 EPHB2 19399172 2415439 Regulation TRIB3 TNFSF10 24795528 1062774 Regulation TRIM21 TLR7 23455675 1958604 Regulation TRIM21 TLR7 25084355 2994331 Regulation TRIM26 TCN1 20087354 434426 Regulation TRIM26 TCN1 20087354 434427 Regulation TRIM26 TCN1 20087354 434489 Regulation TRIM26 TCN1 20087354 434491 Regulation TRIM33 EPHB2 21572418 1925873 Regulation TRIM33 EPHB2 21860657 813152 Regulation TRIM63 FBXO32 23024748 2689687 Regulation TRIM63 FOXO1 19730740 2425824 Regulation TRIM63 FOXO1 23497226 2113860 Regulation TRIM63 FOXO1 23555761 2775254 Regulation TRIM63 FOXO1 24550841 964131 Regulation TRIM63 FOXO1 25032690 2990179 Regulation TRNAC1 RAB31 24885147 246351 Regulation TRPC6 HRH1 24709960 618008 Regulation TRPV1 TGM2 11914134 382169 Regulation TRPV1 TNF 19695100 1897458 Regulation TSC2 EPHB2 20062052 1965861 Regulation TSC2 EPHB2 21200439 2489527 Regulation TSC2 EPHB2 21763421 613344 Regulation TSC2 EPHB2 21904669 799031 Regulation TSC22D3 CCND1 19814803 1852095 Regulation TSLP TLR7 24204367 909803 Regulation TSLP TLR7 PMC3353466 35186 Regulation TSLP TNF 17242164 1544188 Regulation TSPAN1 CD9 25200404 3145448 Regulation TSPAN1 RHO 24040034 2845350 Regulation TUB CDK1 21573187 2522926 Regulation TUB IGF1 25031889 788252 Regulation TUB INS 22966070 724653 Regulation TUB INS 22966070 724673 Regulation TUB INS 25031889 788253 Regulation TUB ISY1 22448250 2613403 Regulation TUB LEP 22966070 724654 Regulation TUB LEP 22966070 724674 Regulation TUB SYF2 22448250 2613402 Regulation TWIST1 EPHB2 23071632 2703605 Regulation TWIST1 JAG1 25144746 3001216 Regulation TXNIP FOXO1 24112473 270034 Regulation TYR EPHB2 20565770 360383 Regulation TYR EPHB2 24743745 2955698 Regulation TYR EPHB2 24743745 2955699 Regulation TYR EPHB2 24743745 2955700 Regulation TYRP1 TNF 23544139 2773550 Regulation UBA52 FHL1 15113405 231121 Regulation UBA7 G0S2 23546556 1141583 Regulation UBA7 G0S2 23546556 1141585 Regulation UBC EPHB2 23894528 2825183 Regulation UBE2C FOXA1 22879989 2673440 Regulation UBE2V1 EPHB2 19305426 2124964 Regulation UBXN4 KRT38 22292069 2593478 Regulation UCA1 CDKN1A 24993775 2171807 Regulation UCA1 CISH 24069250 2852288 Regulation UCA1 ETS2 24069250 2852276 Regulation UCA1 ETS2 24069250 2852279 Regulation UCA1 ETS2 24069250 2852284 Regulation UCA1 PTBP1 24457952 571259 Regulation UCA1 PTBP1 24457952 571287 Regulation UCA1 PTBP1 24457952 571305 Regulation UCA1 PTBP1 24457952 571308 Regulation UCA1 PTBP1 24457952 571315 Regulation UCA1 PTBP1 24457952 571318 Regulation UCA1 TCF12 24069250 2852265 Regulation UCA1 TCF15 24069250 2852266 Regulation UCA1 TCF19 24069250 2852267 Regulation UCA1 TCF20 24069250 2852268 Regulation UCA1 TCF21 24069250 2852269 Regulation UCA1 TCF23 24069250 2852273 Regulation UCA1 TCF24 24069250 2852275 Regulation UCA1 TCF25 24069250 2852274 Regulation UCA1 TCF3 24069250 2852270 Regulation UCA1 TCF4 24069250 2852271 Regulation UCA1 TCF7 24069250 2852272 Regulation UCP1 PGC 22389706 2607963 Regulation UCP1 PGC 23093952 3076036 Regulation UCP1 PGC 23455155 2110747 Regulation UCP1 PGC 23717545 2798145 Regulation UCP2 ANGPT1 24642125 614203 Regulation UCP2 FAS 24086674 2855501 Regulation UCP2 FAS 24275630 1158391 Regulation UCP2 PGC 20566666 715345 Regulation UCP2 PGC 22742515 212913 Regulation UCP2 PGC 25152028 19615 Regulation UCP3 FAS 24275630 1158392 Regulation UCP3 PGC 20566666 715346 Regulation UCP3 PGC 22353542 2113161 Regulation UFD1L PGC 21475702 1238412 Regulation UGCG CLU 24555568 1871855 Regulation UGCG TNF 23049873 2699761 Regulation UGCG TNF 23717489 2797857 Regulation UHRF1 TNFSF10 24941171 2980829 Regulation UMOD EPHB2 22130674 1200741 Regulation UNC13D STAT4 24842371 1576371 Regulation UNC13D STAT4 24842371 1576372 Regulation UNC5B AGAP2 21460185 1789326 Regulation UNC5B AGAP2 21460185 1789327 Regulation UNC5B AKT1 23770988 18008 Regulation UNC5B AKT2 23770988 18009 Regulation UNC5B AKT3 23770988 18010 Regulation UNC5B APLP2 22989406 1896467 Regulation UNC5B PI3 21460185 1789410 Regulation UNC5B UNC5D 24293316 783417 Regulation UNC5D UNC5B 24293316 783418 Regulation UNC93B1 TLR7 23426999 748724 Regulation UNC93B1 TLR7 23426999 748793 Regulation UNC93B1 TLR7 23426999 748794 Regulation UNC93B1 TLR7 25309543 914382 Regulation UPK3B CAPN8 19090995 385367 Regulation UQCRFS1 PGC 25610371 872917 Regulation USO1 CAPN8 21516125 2139145 Regulation USP2 PGC 22447855 722477 Regulation USP2 PGC 22447855 722488 Regulation USP2 PGC 23133608 2713154 Regulation USP37 IFI27 22665064 2147182 Regulation USP5 TNF 24349023 2896635 Regulation UTF1 MAP2K6 24672748 3166331 Regulation UTP15 EPHB2 18404480 3087807 Regulation UTP18 EPHB2 18404480 3087805 Regulation UTP20 EPHB2 18404480 3087803 Regulation UTP23 EPHB2 18404480 3087808 Regulation UTP3 EPHB2 18404480 3087806 Regulation UTP6 EPHB2 18404480 3087804 Regulation UTRN PGC 24447845 3163263 Regulation UTS2R RCAN1 19727437 1055704 Regulation UVRAG FOXO1 23906066 700822 Regulation UXT TNF 17620405 1341840 Regulation VAMP3 RAB31 20347926 833613 Regulation VASP ARSA 22837307 724008 Regulation VAV1 CCND1 25313137 2205102 Regulation VAV1 FAS 21151158 12249 Regulation VCAM1 CFI 22970174 2687507 Regulation VCAM1 EPHB2 23626475 1715005 Regulation VCAM1 EPHB2 PMC3273056 99504 Regulation VCAM1 IL1B 12537603 3103816 Regulation VCAM1 MAP2K6 22031842 2565378 Regulation VCAM1 MAP2K6 23626475 1715011 Regulation VCAM1 NT5E 20181103 1625939 Regulation VCAM1 PECAM1 24199192 184772 Regulation VCAM1 TNF 12537603 3103815 Regulation VCAM1 TNF 1281211 1527730 Regulation VCAM1 TNF 14594625 791964 Regulation VCAM1 TNF 18096615 2032383 Regulation VCAM1 TNF 18289377 2112392 Regulation VCAM1 TNF 19718408 3231704 Regulation VCAM1 TNF 19930605 290768 Regulation VCAM1 TNF 21029292 590586 Regulation VCAM1 TNF 22408625 951342 Regulation VCAM1 TNF 23317476 1155723 Regulation VCAM1 TNF 23317476 1155734 Regulation VCAM1 TNF 23789107 169900 Regulation VCAM1 TNF 23884101 220657 Regulation VCAM1 TNF 23987139 412468 Regulation VCAM1 TNF 23987139 412469 Regulation VCAM1 TNF 24148690 1726361 Regulation VCAM1 TNF 24228622 359353 Regulation VCAM1 TNF 24429403 1709601 Regulation VCAM1 TNF 24516119 1575038 Regulation VCAM1 TNF 24563688 2924007 Regulation VCAM1 TNF 25258478 1762468 Regulation VCAM1 TNF 7520473 1589473 Regulation VCAM1 TNF 8245796 1594752 Regulation VCAM1 TNF 8920874 1599481 Regulation VCAM1 TNF 9625761 1602971 Regulation VCAM1 TNF 9625761 1602972 Regulation VCAM1 TNF 9788885 798107 Regulation VCAM1 TNF PMC4212304 3206314 Regulation VCAN CD14 11545252 1737868 Regulation VCAN CD14 11545252 1737869 Regulation VCAN HAS3 23139787 2713924 Regulation VCL FAS 18056416 1346762 Regulation VCP MUC16 22870330 2672530 Regulation VCP PGC 21475702 1238420 Regulation VDR EPHB2 23785369 907863 Regulation VDR TNF 22880111 2674464 Regulation VDR TNF 22880111 2674465 Regulation VDR TNF 22880111 2674466 Regulation VEGFA ANGPT1 12070283 1523613 Regulation VEGFA ARSA 21826202 2540779 Regulation VEGFA ARSA 21826202 2540784 Regulation VEGFA ARSA 21826202 2540786 Regulation VEGFA ARSA 23555012 2774347 Regulation VEGFA ARSA 23555012 2774349 Regulation VEGFA CCND1 20459741 1855045 Regulation VEGFA CHI3L1 23665676 2152233 Regulation VEGFA CHI3L1 23755018 961397 Regulation VEGFA CHI3L1 23755018 961412 Regulation VEGFA CHI3L1 23755018 961415 Regulation VEGFA CHI3L1 23840582 2815326 Regulation VEGFA CHI3L1 24883044 484405 Regulation VEGFA CTGF 24451141 1123102 Regulation VEGFA EPHB2 18159242 2381597 Regulation VEGFA EPHB2 18852899 2397586 Regulation VEGFA EPHB2 18852899 2397646 Regulation VEGFA EPHB2 21544242 2517400 Regulation VEGFA EPHB2 21672207 1229257 Regulation VEGFA EPHB2 23028886 2693508 Regulation VEGFA EPHB2 23286511 587804 Regulation VEGFA EPHB2 23388056 1479932 Regulation VEGFA EPHB2 24216994 500837 Regulation VEGFA EPHB2 24216994 500841 Regulation VEGFA EPHB2 25332857 3165780 Regulation VEGFA EPHB2 25332857 3165827 Regulation VEGFA EPHB2 25369078 3022198 Regulation VEGFA FOXO1 22384192 2607230 Regulation VEGFA FOXO1 22384192 2607231 Regulation VEGFA FOXO1 22384192 2607237 Regulation VEGFA FOXO1 22384192 2607241 Regulation VEGFA FOXO1 22384192 2607243 Regulation VEGFA FOXO1 22384192 2607249 Regulation VEGFA HBEGF 25384035 3024626 Regulation VEGFA ID1 22139302 1879330 Regulation VEGFA ID1 22139302 1879369 Regulation VEGFA ID1 22139302 1879460 Regulation VEGFA MAP2K6 22069624 3182806 Regulation VEGFA MAP2K6 25332857 3165794 Regulation VEGFA MAP2K6 25332857 3165795 Regulation VEGFA MAP2K6 25332857 3165836 Regulation VEGFA MIP 19936307 1910105 Regulation VEGFA OXTR 22721969 723476 Regulation VEGFA PECAM1 24734240 188948 Regulation VEGFA PECAM1 24959215 2168712 Regulation VEGFA PGC 19696889 2310529 Regulation VEGFA PGC 20214829 1504081 Regulation VEGFA PGC 24416421 2908894 Regulation VEGFA PLAT 22432023 2611596 Regulation VEGFA PLAT 22432023 2611610 Regulation VEGFA PLAU 20067638 255182 Regulation VEGFA PTGER2 20219142 386008 Regulation VEGFA PTGER2 24156238 1726365 Regulation VEGFA S100A7 23618129 3226594 Regulation VEGFA SELL 16831898 1541162 Regulation VEGFA SELL 16831898 1541163 Regulation VEGFA STK39 21234295 648171 Regulation VEGFA TLR7 20539755 2452369 Regulation VEGFA TNF 12110126 99042 Regulation VEGFA TNF 17997858 109358 Regulation VEGFA TNF 18202163 3177754 Regulation VEGFA TNF 20029652 178131 Regulation VEGFA TNF 21349160 3207147 Regulation VEGFA TNF 21747731 1091439 Regulation VEGFA TNF 21747731 1091441 Regulation VEGFA TNF 21747731 1091446 Regulation VEGFA TNF 23922887 2827198 Regulation VEGFA TNF 24141333 88933 Regulation VEGFA TNF 24927773 3102548 Regulation VEGFA TNF 25099287 3144949 Regulation VEGFA TNF 25384035 3024625 Regulation VEGFA TNFSF10 16622457 427504 Regulation VEGFA TNFSF10 16622457 427505 Regulation VEGFA ZFP57 15860771 2016245 Regulation VEGFA ZFP57 15860771 2016246 Regulation VEGFC EPHB2 23424645 2755063 Regulation VEGFC MAP2K6 22745786 2656431 Regulation VEGFC TNF 25120672 2169281 Regulation VEGFC TNF 25387493 85255 Regulation VIM ID1 24970809 2193987 Regulation VIM ID1 25028095 1875770 Regulation VIM JAG1 25144746 3001217 Regulation VIM NEDD9 24058594 2848132 Regulation VIM NEDD9 24058594 2848153 Regulation VIM PODXL 21533279 2515746 Regulation VLDLR PCSK9 24278757 3150692 Regulation VSNL1 EGF 22479362 2614933 Regulation VSNL1 EGF 22479362 2614949 Regulation VSNL1 SNAI1 22479362 2614943 Regulation VTI1A RAB31 20347926 833640 Regulation VTN PLAU 23843894 3177310 Regulation VWF TNF 25422582 743484 Regulation WAS CAPN8 25200405 1234612 Regulation WDR61 ARSA 18475637 1745106 Regulation WDR61 LPCAT1 25415055 177560 Regulation WDR61 TNF 3119758 1580159 Regulation WDR61 TNF 3119758 1580160 Regulation WDR61 TNF 3119758 1580181 Regulation WFDC2 IPO11 24975515 3143881 Regulation WFDC2 IPO11 24975515 3143888 Regulation WFDC2 IPO13 24975515 3143878 Regulation WFDC2 IPO13 24975515 3143885 Regulation WFDC2 IPO4 24975515 3143880 Regulation WFDC2 IPO4 24975515 3143887 Regulation WFDC2 IPO5 24975515 3143882 Regulation WFDC2 IPO5 24975515 3143889 Regulation WFDC2 IPO7 24975515 3143883 Regulation WFDC2 IPO7 24975515 3143890 Regulation WFDC2 IPO8 24975515 3143884 Regulation WFDC2 IPO8 24975515 3143891 Regulation WFDC2 IPO9 24975515 3143879 Regulation WFDC2 IPO9 24975515 3143886 Regulation WFDC2 VEGFA 24389815 3139192 Regulation WIF1 GC 24632949 548653 Regulation WIF1 MYLIP 24755295 1873933 Regulation WIF1 MYLIP 24755295 1873934 Regulation WIF1 SHH 24632949 548651 Regulation WIF1 SHH 24632949 548652 Regulation WIF1 SHH 24632949 548671 Regulation WIF1 SMAD1 24632949 548680 Regulation WIF1 WNT1 24632949 548640 Regulation WIF1 WNT1 24632949 548672 Regulation WIF1 WNT11 24632949 548641 Regulation WIF1 WNT11 24632949 548673 Regulation WIF1 WNT16 24632949 548646 Regulation WIF1 WNT16 24632949 548678 Regulation WIF1 WNT2 24632949 548642 Regulation WIF1 WNT2 24632949 548674 Regulation WIF1 WNT3 24632949 548643 Regulation WIF1 WNT3 24632949 548675 Regulation WIF1 WNT4 24632949 548644 Regulation WIF1 WNT4 24632949 548676 Regulation WIF1 WNT6 24632949 548645 Regulation WIF1 WNT6 24632949 548677 Regulation WNK1 EGLN3 25420773 1947404 Regulation WNK1 TNF 17565690 1846540 Regulation WNK1 TNF 20693346 716057 Regulation WNK1 TNF 21306441 1889362 Regulation WNK1 TNF 21573233 2523017 Regulation WNK1 TNF 21765477 2141238 Regulation WNK1 TNF 21904602 2550399 Regulation WNK1 TNF 21904602 2550404 Regulation WNK1 TNF 21915344 2553424 Regulation WNK1 TNF 22076152 2570312 Regulation WNK1 TNF 22076152 2570316 Regulation WNK1 TNF 22076152 2570319 Regulation WNK1 TNF 22110478 832158 Regulation WNK1 TNF 22723832 2654769 Regulation WNK1 TNF 24614867 2933192 Regulation WNK1 TNF 25310191 3015022 Regulation WNK1 TNF 9625761 1602976 Regulation WNT1 AXIN2 11739413 1277193 Regulation WNT1 AXIN2 11806834 994517 Regulation WNT1 AXIN2 17961224 1645898 Regulation WNT1 AXIN2 19888210 1903074 Regulation WNT1 AXIN2 19909509 400643 Regulation WNT1 AXIN2 21170416 2487326 Regulation WNT1 AXIN2 21471006 1789874 Regulation WNT1 AXIN2 21799911 2539151 Regulation WNT1 AXIN2 21814488 2276790 Regulation WNT1 AXIN2 22303459 2594528 Regulation WNT1 AXIN2 22957046 2686157 Regulation WNT1 AXIN2 22957046 2686158 Regulation WNT1 AXIN2 22957046 2686159 Regulation WNT1 AXIN2 22957046 2686335 Regulation WNT1 AXIN2 23155463 2717410 Regulation WNT1 AXIN2 23869245 2821215 Regulation WNT1 AXIN2 24324671 2891019 Regulation WNT1 AXIN2 24474204 3081461 Regulation WNT1 AXIN2 24995284 193996 Regulation WNT1 CCND1 15601467 248591 Regulation WNT1 CCND1 20865053 2475151 Regulation WNT1 CCND1 24755523 2189362 Regulation WNT1 CTGF 24152728 1819398 Regulation WNT1 EMP1 24920608 784946 Regulation WNT1 EPHB2 24743024 2189230 Regulation WNT1 FZD4 24252524 538375 Regulation WNT1 GPR115 24339877 2892424 Regulation WNT1 GPR132 24339877 2892413 Regulation WNT1 GPR87 24339877 2892495 Regulation WNT1 JAG1 23560082 2776878 Regulation WNT1 MSX1 22383889 2332136 Regulation WNT1 NEDD9 24058594 2848142 Regulation WNT1 NES 25056574 475378 Regulation WNT1 NES 25056574 475385 Regulation WNT1 PCDH19 19956686 2311746 Regulation WNT1 PCDH8 19956686 2311751 Regulation WNT1 RGS2 23755177 2801771 Regulation WNT1 TLR7 23832647 1022237 Regulation WNT1 TMEM100 19424478 669229 Regulation WNT1 TMEM156 19424478 669247 Regulation WNT1 TMEM211 19424478 669327 Regulation WNT1 TMEM213 19424478 669264 Regulation WNT1 TNF 18511911 763726 Regulation WNT1 TNF 24286133 130222 Regulation WNT1 TNF 24286133 130223 Regulation WNT1 TNF 24286133 130328 Regulation WNT1 TNF 24318398 697076 Regulation WNT1 TNF 24318398 697091 Regulation WNT1 WIF1 19136570 1642816 Regulation WNT1 WIF1 20334650 1504098 Regulation WNT1 WIF1 24632949 548633 Regulation WNT11 AXIN2 11739413 1277195 Regulation WNT11 AXIN2 11806834 994519 Regulation WNT11 AXIN2 17961224 1645900 Regulation WNT11 AXIN2 19888210 1903076 Regulation WNT11 AXIN2 19909509 400645 Regulation WNT11 AXIN2 21170416 2487329 Regulation WNT11 AXIN2 21471006 1789877 Regulation WNT11 AXIN2 21799911 2539153 Regulation WNT11 AXIN2 21814488 2276792 Regulation WNT11 AXIN2 22303459 2594530 Regulation WNT11 AXIN2 22957046 2686169 Regulation WNT11 AXIN2 22957046 2686170 Regulation WNT11 AXIN2 22957046 2686171 Regulation WNT11 AXIN2 22957046 2686338 Regulation WNT11 AXIN2 23155463 2717412 Regulation WNT11 AXIN2 23869245 2821216 Regulation WNT11 AXIN2 24324671 2891020 Regulation WNT11 AXIN2 24474204 3081463 Regulation WNT11 AXIN2 24995284 193998 Regulation WNT11 CCND1 20865053 2475153 Regulation WNT11 CCND1 24755523 2189363 Regulation WNT11 CTGF 24152728 1819399 Regulation WNT11 EMP1 24920608 784949 Regulation WNT11 EPHB2 24743024 2189244 Regulation WNT11 FZD4 24252524 538376 Regulation WNT11 GPR115 24339877 2892519 Regulation WNT11 GPR132 24339877 2892508 Regulation WNT11 GPR87 24339877 2892590 Regulation WNT11 JAG1 23560082 2776880 Regulation WNT11 MSX1 22383889 2332138 Regulation WNT11 NEDD9 24058594 2848143 Regulation WNT11 NES 25056574 475379 Regulation WNT11 NES 25056574 475386 Regulation WNT11 PCDH19 19956686 2311757 Regulation WNT11 PCDH8 19956686 2311762 Regulation WNT11 RGS2 23755177 2801773 Regulation WNT11 TLR7 23832647 1022247 Regulation WNT11 TMEM100 19424478 669398 Regulation WNT11 TMEM156 19424478 669416 Regulation WNT11 TMEM211 19424478 669496 Regulation WNT11 TMEM213 19424478 669433 Regulation WNT11 TNF 18511911 763727 Regulation WNT11 TNF 24286133 130224 Regulation WNT11 TNF 24286133 130225 Regulation WNT11 TNF 24286133 130330 Regulation WNT11 TNF 24318398 697077 Regulation WNT11 TNF 24318398 697092 Regulation WNT11 WIF1 19136570 1642818 Regulation WNT11 WIF1 20334650 1504099 Regulation WNT11 WIF1 24632949 548634 Regulation WNT16 AXIN2 11739413 1277205 Regulation WNT16 AXIN2 11806834 994529 Regulation WNT16 AXIN2 17961224 1645910 Regulation WNT16 AXIN2 19888210 1903086 Regulation WNT16 AXIN2 19909509 400655 Regulation WNT16 AXIN2 21170416 2487344 Regulation WNT16 AXIN2 21471006 1789892 Regulation WNT16 AXIN2 21799911 2539163 Regulation WNT16 AXIN2 21814488 2276802 Regulation WNT16 AXIN2 22303459 2594540 Regulation WNT16 AXIN2 22957046 2686229 Regulation WNT16 AXIN2 22957046 2686230 Regulation WNT16 AXIN2 22957046 2686231 Regulation WNT16 AXIN2 22957046 2686353 Regulation WNT16 AXIN2 23155463 2717422 Regulation WNT16 AXIN2 23869245 2821221 Regulation WNT16 AXIN2 24324671 2891025 Regulation WNT16 AXIN2 24474204 3081473 Regulation WNT16 AXIN2 24995284 194008 Regulation WNT16 CCND1 20865053 2475163 Regulation WNT16 CCND1 24755523 2189368 Regulation WNT16 CTGF 24152728 1819405 Regulation WNT16 EMP1 24920608 784964 Regulation WNT16 EPHB2 24743024 2189314 Regulation WNT16 FZD4 24252524 538381 Regulation WNT16 GPR115 24339877 2893075 Regulation WNT16 GPR132 24339877 2893064 Regulation WNT16 GPR87 24339877 2893146 Regulation WNT16 JAG1 23560082 2776890 Regulation WNT16 MSX1 22383889 2332148 Regulation WNT16 NEDD9 24058594 2848148 Regulation WNT16 NES 25056574 475384 Regulation WNT16 NES 25056574 475391 Regulation WNT16 PCDH19 19956686 2311812 Regulation WNT16 PCDH8 19956686 2311817 Regulation WNT16 RGS2 23755177 2801783 Regulation WNT16 TLR7 23832647 1022325 Regulation WNT16 TMEM100 19424478 670285 Regulation WNT16 TMEM156 19424478 670303 Regulation WNT16 TMEM211 19424478 670383 Regulation WNT16 TMEM213 19424478 670320 Regulation WNT16 TNF 18511911 763732 Regulation WNT16 TNF 24286133 130234 Regulation WNT16 TNF 24286133 130235 Regulation WNT16 TNF 24286133 130340 Regulation WNT16 TNF 24318398 697082 Regulation WNT16 TNF 24318398 697097 Regulation WNT16 WIF1 19136570 1642828 Regulation WNT16 WIF1 20334650 1504104 Regulation WNT16 WIF1 24632949 548639 Regulation WNT2 AXIN2 11739413 1277197 Regulation WNT2 AXIN2 11806834 994521 Regulation WNT2 AXIN2 17961224 1645902 Regulation WNT2 AXIN2 19888210 1903078 Regulation WNT2 AXIN2 19909509 400647 Regulation WNT2 AXIN2 21170416 2487332 Regulation WNT2 AXIN2 21471006 1789880 Regulation WNT2 AXIN2 21799911 2539155 Regulation WNT2 AXIN2 21814488 2276794 Regulation WNT2 AXIN2 22303459 2594532 Regulation WNT2 AXIN2 22957046 2686181 Regulation WNT2 AXIN2 22957046 2686182 Regulation WNT2 AXIN2 22957046 2686183 Regulation WNT2 AXIN2 22957046 2686341 Regulation WNT2 AXIN2 23155463 2717414 Regulation WNT2 AXIN2 23869245 2821217 Regulation WNT2 AXIN2 24324671 2891021 Regulation WNT2 AXIN2 24474204 3081465 Regulation WNT2 AXIN2 24995284 194000 Regulation WNT2 CCND1 20865053 2475155 Regulation WNT2 CCND1 24755523 2189364 Regulation WNT2 CTGF 24152728 1819400 Regulation WNT2 EMP1 24920608 784952 Regulation WNT2 EPHB2 24743024 2189258 Regulation WNT2 FZD4 24252524 538377 Regulation WNT2 GPR115 24339877 2892614 Regulation WNT2 GPR132 24339877 2892603 Regulation WNT2 GPR87 24339877 2892685 Regulation WNT2 JAG1 23560082 2776882 Regulation WNT2 MSX1 22383889 2332140 Regulation WNT2 NEDD9 24058594 2848144 Regulation WNT2 NES 25056574 475380 Regulation WNT2 NES 25056574 475387 Regulation WNT2 PCDH19 19956686 2311768 Regulation WNT2 PCDH8 19956686 2311773 Regulation WNT2 RGS2 23755177 2801775 Regulation WNT2 TLR7 23832647 1022257 Regulation WNT2 TMEM100 19424478 669567 Regulation WNT2 TMEM156 19424478 669585 Regulation WNT2 TMEM211 19424478 669665 Regulation WNT2 TMEM213 19424478 669602 Regulation WNT2 TNF 18511911 763728 Regulation WNT2 TNF 24286133 130226 Regulation WNT2 TNF 24286133 130227 Regulation WNT2 TNF 24286133 130332 Regulation WNT2 TNF 24318398 697078 Regulation WNT2 TNF 24318398 697093 Regulation WNT2 WIF1 19136570 1642820 Regulation WNT2 WIF1 20334650 1504100 Regulation WNT2 WIF1 24632949 548635 Regulation WNT3 AXIN2 11739413 1277199 Regulation WNT3 AXIN2 11806834 994523 Regulation WNT3 AXIN2 17961224 1645904 Regulation WNT3 AXIN2 19888210 1903080 Regulation WNT3 AXIN2 19909509 400649 Regulation WNT3 AXIN2 21170416 2487335 Regulation WNT3 AXIN2 21471006 1789883 Regulation WNT3 AXIN2 21799911 2539157 Regulation WNT3 AXIN2 21814488 2276796 Regulation WNT3 AXIN2 22303459 2594534 Regulation WNT3 AXIN2 22957046 2686193 Regulation WNT3 AXIN2 22957046 2686194 Regulation WNT3 AXIN2 22957046 2686195 Regulation WNT3 AXIN2 22957046 2686344 Regulation WNT3 AXIN2 23155463 2717416 Regulation WNT3 AXIN2 23869245 2821218 Regulation WNT3 AXIN2 24324671 2891022 Regulation WNT3 AXIN2 24474204 3081467 Regulation WNT3 AXIN2 24995284 194002 Regulation WNT3 CCND1 20865053 2475157 Regulation WNT3 CCND1 24755523 2189365 Regulation WNT3 CTGF 24152728 1819401 Regulation WNT3 EMP1 24920608 784955 Regulation WNT3 EPHB2 24743024 2189272 Regulation WNT3 FZD4 24252524 538378 Regulation WNT3 GPR115 24339877 2892709 Regulation WNT3 GPR132 24339877 2892698 Regulation WNT3 GPR87 24339877 2892780 Regulation WNT3 JAG1 23560082 2776884 Regulation WNT3 MSX1 22383889 2332142 Regulation WNT3 NEDD9 24058594 2848145 Regulation WNT3 NES 25056574 475381 Regulation WNT3 NES 25056574 475388 Regulation WNT3 PCDH19 19956686 2311779 Regulation WNT3 PCDH8 19956686 2311784 Regulation WNT3 RGS2 23755177 2801777 Regulation WNT3 TLR7 23832647 1022267 Regulation WNT3 TMEM100 19424478 669736 Regulation WNT3 TMEM156 19424478 669754 Regulation WNT3 TMEM211 19424478 669834 Regulation WNT3 TMEM213 19424478 669771 Regulation WNT3 TNF 18511911 763729 Regulation WNT3 TNF 24286133 130228 Regulation WNT3 TNF 24286133 130229 Regulation WNT3 TNF 24286133 130334 Regulation WNT3 TNF 24318398 697079 Regulation WNT3 TNF 24318398 697094 Regulation WNT3 WIF1 19136570 1642822 Regulation WNT3 WIF1 20334650 1504101 Regulation WNT3 WIF1 24632949 548636 Regulation WNT3A MAP2K6 23118616 2280951 Regulation WNT4 AXIN2 11739413 1277201 Regulation WNT4 AXIN2 11806834 994525 Regulation WNT4 AXIN2 17961224 1645906 Regulation WNT4 AXIN2 19888210 1903082 Regulation WNT4 AXIN2 19909509 400651 Regulation WNT4 AXIN2 21170416 2487338 Regulation WNT4 AXIN2 21471006 1789886 Regulation WNT4 AXIN2 21799911 2539159 Regulation WNT4 AXIN2 21814488 2276798 Regulation WNT4 AXIN2 22303459 2594536 Regulation WNT4 AXIN2 22957046 2686205 Regulation WNT4 AXIN2 22957046 2686206 Regulation WNT4 AXIN2 22957046 2686207 Regulation WNT4 AXIN2 22957046 2686347 Regulation WNT4 AXIN2 23155463 2717418 Regulation WNT4 AXIN2 23869245 2821219 Regulation WNT4 AXIN2 24324671 2891023 Regulation WNT4 AXIN2 24474204 3081469 Regulation WNT4 AXIN2 24995284 194004 Regulation WNT4 CCND1 20865053 2475159 Regulation WNT4 CCND1 24755523 2189366 Regulation WNT4 CTGF 24152728 1819402 Regulation WNT4 EMP1 24920608 784958 Regulation WNT4 EPHB2 24743024 2189286 Regulation WNT4 FZD4 24252524 538379 Regulation WNT4 GPR115 24339877 2892804 Regulation WNT4 GPR132 24339877 2892793 Regulation WNT4 GPR87 24339877 2892875 Regulation WNT4 JAG1 23560082 2776886 Regulation WNT4 JAG1 23560082 2776907 Regulation WNT4 MSX1 22383889 2332144 Regulation WNT4 NEDD9 24058594 2848146 Regulation WNT4 NES 25056574 475382 Regulation WNT4 NES 25056574 475389 Regulation WNT4 PCDH19 19956686 2311790 Regulation WNT4 PCDH8 19956686 2311795 Regulation WNT4 RGS2 23755177 2801779 Regulation WNT4 TLR7 23832647 1022277 Regulation WNT4 TMEM100 19424478 669905 Regulation WNT4 TMEM156 19424478 669923 Regulation WNT4 TMEM211 19424478 670003 Regulation WNT4 TMEM213 19424478 669940 Regulation WNT4 TNF 18511911 763730 Regulation WNT4 TNF 24286133 130230 Regulation WNT4 TNF 24286133 130231 Regulation WNT4 TNF 24286133 130336 Regulation WNT4 TNF 24318398 697080 Regulation WNT4 TNF 24318398 697095 Regulation WNT4 WIF1 19136570 1642824 Regulation WNT4 WIF1 20334650 1504102 Regulation WNT4 WIF1 24632949 548637 Regulation WNT6 AXIN2 11739413 1277203 Regulation WNT6 AXIN2 11806834 994527 Regulation WNT6 AXIN2 17961224 1645908 Regulation WNT6 AXIN2 19888210 1903084 Regulation WNT6 AXIN2 19909509 400653 Regulation WNT6 AXIN2 21170416 2487341 Regulation WNT6 AXIN2 21471006 1789889 Regulation WNT6 AXIN2 21799911 2539161 Regulation WNT6 AXIN2 21814488 2276800 Regulation WNT6 AXIN2 22303459 2594538 Regulation WNT6 AXIN2 22957046 2686217 Regulation WNT6 AXIN2 22957046 2686218 Regulation WNT6 AXIN2 22957046 2686219 Regulation WNT6 AXIN2 22957046 2686350 Regulation WNT6 AXIN2 23155463 2717420 Regulation WNT6 AXIN2 23869245 2821220 Regulation WNT6 AXIN2 24324671 2891024 Regulation WNT6 AXIN2 24474204 3081471 Regulation WNT6 AXIN2 24995284 194006 Regulation WNT6 CCND1 20865053 2475161 Regulation WNT6 CCND1 24755523 2189367 Regulation WNT6 CTGF 24152728 1819403 Regulation WNT6 EMP1 24920608 784961 Regulation WNT6 EPHB2 24743024 2189300 Regulation WNT6 FZD4 24252524 538380 Regulation WNT6 GPR115 24339877 2892899 Regulation WNT6 GPR132 24339877 2892888 Regulation WNT6 GPR87 24339877 2892970 Regulation WNT6 JAG1 23560082 2776888 Regulation WNT6 MSX1 22383889 2332146 Regulation WNT6 NEDD9 24058594 2848147 Regulation WNT6 NES 25056574 475383 Regulation WNT6 NES 25056574 475390 Regulation WNT6 PCDH19 19956686 2311801 Regulation WNT6 PCDH8 19956686 2311806 Regulation WNT6 RGS2 23755177 2801781 Regulation WNT6 TLR7 23832647 1022287 Regulation WNT6 TMEM100 19424478 670074 Regulation WNT6 TMEM156 19424478 670092 Regulation WNT6 TMEM211 19424478 670172 Regulation WNT6 TMEM213 19424478 670109 Regulation WNT6 TNF 18511911 763731 Regulation WNT6 TNF 24286133 130232 Regulation WNT6 TNF 24286133 130233 Regulation WNT6 TNF 24286133 130338 Regulation WNT6 TNF 24318398 697081 Regulation WNT6 TNF 24318398 697096 Regulation WNT6 WIF1 19136570 1642826 Regulation WNT6 WIF1 20334650 1504103 Regulation WNT6 WIF1 24632949 548638 Regulation WNT7A GRHL2 23284647 2730360 Regulation WNT7A GRHL2 23284647 2730378 Regulation WNT7A IGF1 22179044 1928144 Regulation WNT7A IGF1 25163459 1239294 Regulation WNT7A IGF2 22179044 1928145 Regulation WNT7A IGF2 23213437 168795 Regulation WNT7A IGF2 25163459 1239295 Regulation WNT7A SHH 23140504 1997937 Regulation WNT7A SYN1 25170755 3003873 Regulation WTS F2R 23940457 2283790 Regulation WWP1 IFI27 23573293 2778199 Regulation XBP1 EPHB2 23277279 610864 Regulation XBP1 EPHB2 23277279 610878 Regulation XIAP FOXO1 23653632 883832 Regulation XIAP MAP2K6 23056924 140512 Regulation XIAP TNF 12967350 3095100 Regulation XIAP TNFSF10 23703388 561938 Regulation XPO1 NES 22362746 2072649 Regulation XPO1 NES 25119991 2997192 Regulation XRCC5 PECAM1 10725328 1256588 Regulation XRCC5 TLR7 25118589 1945032 Regulation XRCC6 CLU 21042904 3204942 Regulation XRCC6 CLU 21042904 3204956 Regulation XRCC6 PECAM1 10725328 1256591 Regulation XRCC6 TLR7 25118589 1945118 Regulation YAP1 EPHB2 23857250 2156945 Regulation YAP1 MAP2K6 23857250 2156951 Regulation YAP1 NES 21156173 850872 Regulation YBX3 MAP2K6 21368869 550797 Regulation YWHAB EPHB2 24578720 3177452 Regulation YWHAH RASD1 21915321 2553244 Regulation YY1 TNF 23226345 2724302 Regulation YY1 ZFP57 22355521 3129840 Regulation ZAP70 ITGAL 24596147 753317 Regulation ZBTB16 HSPB3 17973985 1002919 Regulation ZC3H12A EPHB2 20137095 375160 Regulation ZC3H12A EPHB2 20137095 375190 Regulation ZC3H12A RNASE1 22561375 2075077 Regulation ZC3H12A RNASE7 22561375 2075085 Regulation ZEB1 EPHB2 24318272 2186032 Regulation ZEB1 JAG1 21224847 768964 Regulation ZEB1 MAP2K6 24318272 2186038 Regulation ZEB2 IL1R2 21747944 2534787 Regulation ZFP36 CAPN8 21731431 1091142 Regulation ZFP36 EPHB2 20644716 2455975 Regulation ZFP36 TNF 12823857 99883 Regulation ZFP36 TNF 20221403 2442565 Regulation ZFP36 TNF PMC2834070 134565 Regulation ZFP36L1 EPHB2 25106868 2103834 Regulation ZFP36L1 ZFP57 24999452 948384 Regulation ZFP57 BMI1 20808772 2472235 Regulation ZFP57 EBF1 23569325 1571545 Regulation ZFP57 ENO2 21173110 1383485 Regulation ZFP57 HDAC3 21173110 1383486 Regulation ZFP57 MAPK3 24722354 2951241 Regulation ZFP57 MAPK3 24722354 2951322 Regulation ZFP57 MAPK3 24722354 2951360 Regulation ZFP57 NANOG 25122140 2301298 Regulation ZFP57 OLIG1 22355521 3129896 Regulation ZFP57 TDGF1P4 24550733 2356447 Regulation ZFP57 TRIM28 23451074 2757450 Regulation ZFP57 YY1 22355521 3129865 Regulation ZFP57 ZFP36L1 24999452 948402 Regulation ZFP57 ZNF24 22355521 3129866 Regulation ZFP57 ZNF423 24081948 1573728 Regulation ZFP57 ZNF704 20169146 2441178 Regulation ZGLP1 EPHB2 23844037 2819053 Regulation ZGLP1 GLP1R 22474415 832741 Regulation ZGLP1 GLP1R 22474415 832752 Regulation ZGLP1 GLP1R 24327600 787521 Regulation ZIC2 ALAS2 22369568 336017 Regulation ZNF10 TNF 20577653 1911230 Regulation ZNF100 TNF 20577653 1911231 Regulation ZNF101 TNF 20577653 1911232 Regulation ZNF106 TNF 20577653 1911233 Regulation ZNF107 TNF 20577653 1911234 Regulation ZNF112 TNF 20577653 1911235 Regulation ZNF114 TNF 20577653 1911236 Regulation ZNF117 TNF 20577653 1911237 Regulation ZNF12 TNF 20577653 1911238 Regulation ZNF121 TNF 20577653 1911239 Regulation ZNF124 TNF 20577653 1911240 Regulation ZNF131 TNF 20577653 1911241 Regulation ZNF132 TNF 20577653 1911242 Regulation ZNF133 TNF 20577653 1911243 Regulation ZNF134 TNF 20577653 1911244 Regulation ZNF135 TNF 20577653 1911245 Regulation ZNF136 TNF 20577653 1911246 Regulation ZNF138 TNF 20577653 1911247 Regulation ZNF14 TNF 20577653 1911248 Regulation ZNF140 TNF 20577653 1911249 Regulation ZNF141 TNF 20577653 1911250 Regulation ZNF142 TNF 20577653 1911251 Regulation ZNF143 TNF 20577653 1911252 Regulation ZNF146 TNF 20577653 1911253 Regulation ZNF148 ID1 25028095 1875771 Regulation ZNF148 ID1 25028095 1875814 Regulation ZNF148 TNF 20577653 1911254 Regulation ZNF154 TNF 20577653 1911255 Regulation ZNF155 TNF 20577653 1911256 Regulation ZNF157 TNF 20577653 1911257 Regulation ZNF16 TNF 20577653 1911259 Regulation ZNF160 TNF 20577653 1911260 Regulation ZNF165 TNF 20577653 1911261 Regulation ZNF169 TNF 20577653 1911262 Regulation ZNF17 TNF 20577653 1911263 Regulation ZNF174 TNF 20577653 1911264 Regulation ZNF175 TNF 20577653 1911265 Regulation ZNF177 TNF 20577653 1911266 Regulation ZNF18 TNF 20577653 1911267 Regulation ZNF180 TNF 20577653 1911268 Regulation ZNF181 TNF 20577653 1911269 Regulation ZNF182 TNF 20577653 1911283 Regulation ZNF184 TNF 20577653 1911270 Regulation ZNF185 TNF 20577653 1911271 Regulation ZNF189 TNF 20577653 1911272 Regulation ZNF19 TNF 20577653 1911273 Regulation ZNF195 TNF 20577653 1911274 Regulation ZNF197 TNF 20577653 1911275 Regulation ZNF2 TNF 20577653 1911276 Regulation ZNF20 TNF 20577653 1911277 Regulation ZNF200 TNF 20577653 1911278 Regulation ZNF202 TNF 20577653 1911279 Regulation ZNF205 TNF 20577653 1911280 Regulation ZNF207 TNF 20577653 1911281 Regulation ZNF208 TNF 20577653 1911282 Regulation ZNF211 TNF 20577653 1911284 Regulation ZNF212 TNF 20577653 1911285 Regulation ZNF213 TNF 20577653 1911286 Regulation ZNF214 TNF 20577653 1911287 Regulation ZNF215 TNF 20577653 1911288 Regulation ZNF217 TNF 20577653 1911289 Regulation ZNF219 TNF 20577653 1911290 Regulation ZNF22 TNF 20577653 1911291 Regulation ZNF221 TNF 20577653 1911292 Regulation ZNF222 TNF 20577653 1911293 Regulation ZNF223 TNF 20577653 1911294 Regulation ZNF224 TNF 20577653 1911295 Regulation ZNF225 TNF 20577653 1911296 Regulation ZNF226 TNF 20577653 1911297 Regulation ZNF227 TNF 20577653 1911298 Regulation ZNF229 TNF 20577653 1911299 Regulation ZNF23 TNF 20577653 1911300 Regulation ZNF230 TNF 20577653 1911301 Regulation ZNF232 TNF 20577653 1911302 Regulation ZNF233 TNF 20577653 1911666 Regulation ZNF234 TNF 20577653 1911303 Regulation ZNF235 TNF 20577653 1911229 Regulation ZNF236 TNF 20577653 1911304 Regulation ZNF239 TNF 20577653 1911305 Regulation ZNF24 TNF 20577653 1911306 Regulation ZNF248 TNF 20577653 1911307 Regulation ZNF25 TNF 20577653 1911308 Regulation ZNF250 TNF 20577653 1911309 Regulation ZNF251 TNF 20577653 1911310 Regulation ZNF253 TNF 20577653 1911367 Regulation ZNF254 TNF 20577653 1911311 Regulation ZNF256 TNF 20577653 1911312 Regulation ZNF257 TNF 20577653 1911368 Regulation ZNF259 TNF 20577653 1911313 Regulation ZNF26 TNF 20577653 1911314 Regulation ZNF260 TNF 20577653 1911369 Regulation ZNF263 TNF 20577653 1911315 Regulation ZNF264 TNF 20577653 1911316 Regulation ZNF266 TNF 20577653 1911317 Regulation ZNF267 TNF 20577653 1911318 Regulation ZNF268 TNF 20577653 1911319 Regulation ZNF271 TNF 20577653 1911320 Regulation ZNF273 TNF 20577653 1911321 Regulation ZNF274 TNF 20577653 1911322 Regulation ZNF275 TNF 20577653 1911323 Regulation ZNF276 TNF 20577653 1911472 Regulation ZNF277 TNF 20577653 1911324 Regulation ZNF28 TNF 20577653 1911325 Regulation ZNF281 TNF 20577653 1911326 Regulation ZNF282 TNF 20577653 1911327 Regulation ZNF283 TNF 20577653 1911328 Regulation ZNF284 TNF 20577653 1911329 Regulation ZNF285 TNF 20577653 1911330 Regulation ZNF287 TNF 20577653 1911370 Regulation ZNF292 TNF 20577653 1911410 Regulation ZNF296 TNF 20577653 1911388 Regulation ZNF3 TNF 20577653 1911331 Regulation ZNF30 TNF 20577653 1911332 Regulation ZNF300 TNF 20577653 1911333 Regulation ZNF302 TNF 20577653 1911378 Regulation ZNF304 TNF 20577653 1911371 Regulation ZNF311 TNF 20577653 1911377 Regulation ZNF316 TNF 20577653 1911376 Regulation ZNF317 TNF 20577653 1911372 Regulation ZNF318 TNF 20577653 1911373 Regulation ZNF319 TNF 20577653 1911374 Regulation ZNF32 TNF 20577653 1911334 Regulation ZNF320 TNF 20577653 1911375 Regulation ZNF322 TNF 20577653 1911479 Regulation ZNF324 TNF 20577653 1911379 Regulation ZNF326 TNF 20577653 1911380 Regulation ZNF329 TNF 20577653 1911381 Regulation ZNF330 TNF 20577653 1911382 Regulation ZNF331 TNF 20577653 1911383 Regulation ZNF333 TNF 20577653 1911384 Regulation ZNF334 TNF 20577653 1911385 Regulation ZNF335 TNF 20577653 1911386 Regulation ZNF337 TNF 20577653 1911387 Regulation ZNF34 TNF 20577653 1911335 Regulation ZNF341 TNF 20577653 1911389 Regulation ZNF343 TNF 20577653 1911390 Regulation ZNF345 TNF 20577653 1911393 Regulation ZNF346 TNF 20577653 1911394 Regulation ZNF347 TNF 20577653 1911395 Regulation ZNF35 TNF 20577653 1911336 Regulation ZNF350 TNF 20577653 1911396 Regulation ZNF358 TNF 20577653 1911400 Regulation ZNF362 TNF 20577653 1911404 Regulation ZNF365 TNF 20577653 1911406 Regulation ZNF366 TNF 20577653 1911407 Regulation ZNF367 TNF 20577653 1911408 Regulation ZNF382 TNF 20577653 1911401 Regulation ZNF383 TNF 20577653 1911411 Regulation ZNF384 TNF 20577653 1911228 Regulation ZNF391 TNF 20577653 1911413 Regulation ZNF394 TNF 20577653 1911416 Regulation ZNF395 TNF 20577653 1911412 Regulation ZNF396 TNF 20577653 1911415 Regulation ZNF397 TNF 20577653 1911414 Regulation ZNF398 TNF 20577653 1911409 Regulation ZNF404 TNF 20577653 1911417 Regulation ZNF407 TNF 20577653 1911418 Regulation ZNF408 TNF 20577653 1911419 Regulation ZNF41 TNF 20577653 1911337 Regulation ZNF410 TNF 20577653 1911420 Regulation ZNF414 TNF 20577653 1911424 Regulation ZNF415 TNF 20577653 1911425 Regulation ZNF416 TNF 20577653 1911426 Regulation ZNF417 TNF 20577653 1911427 Regulation ZNF418 TNF 20577653 1911428 Regulation ZNF419 TNF 20577653 1911429 Regulation ZNF420 TNF 20577653 1911430 Regulation ZNF423 TNF 20577653 1911399 Regulation ZNF425 TNF 20577653 1911431 Regulation ZNF426 TNF 20577653 1911432 Regulation ZNF428 TNF 20577653 1911433 Regulation ZNF429 TNF 20577653 1911440 Regulation ZNF43 TNF 20577653 1911338 Regulation ZNF430 TNF 20577653 1911435 Regulation ZNF431 TNF 20577653 1911436 Regulation ZNF432 TNF 20577653 1911437 Regulation ZNF433 TNF 20577653 1911438 Regulation ZNF436 TNF 20577653 1911439 Regulation ZNF438 TNF 20577653 1911447 Regulation ZNF439 TNF 20577653 1911441 Regulation ZNF44 TNF 20577653 1911339 Regulation ZNF440 TNF 20577653 1911442 Regulation ZNF441 TNF 20577653 1911443 Regulation ZNF442 TNF 20577653 1911444 Regulation ZNF443 TNF 20577653 1911445 Regulation ZNF444 TNF 20577653 1911391 Regulation ZNF445 TNF 20577653 1911446 Regulation ZNF446 TNF 20577653 1911448 Regulation ZNF449 TNF 20577653 1911449 Regulation ZNF45 TNF 20577653 1911340 Regulation ZNF451 TNF 20577653 1911450 Regulation ZNF454 TNF 20577653 1911451 Regulation ZNF460 TNF 20577653 1911452 Regulation ZNF461 TNF 20577653 1911453 Regulation ZNF462 TNF 20577653 1911454 Regulation ZNF467 TNF 20577653 1911463 Regulation ZNF468 TNF 20577653 1911688 Regulation ZNF469 TNF 20577653 1911465 Regulation ZNF470 TNF 20577653 1911461 Regulation ZNF471 TNF 20577653 1911466 Regulation ZNF473 TNF 20577653 1911467 Regulation ZNF474 TNF 20577653 1911468 Regulation ZNF479 TNF 20577653 1911469 Regulation ZNF48 TNF 20577653 1911341 Regulation ZNF480 TNF 20577653 1911471 Regulation ZNF483 TNF 20577653 1911473 Regulation ZNF484 TNF 20577653 1911474 Regulation ZNF485 TNF 20577653 1911475 Regulation ZNF486 TNF 20577653 1911434 Regulation ZNF487 TNF 20577653 1911476 Regulation ZNF488 TNF 20577653 1911477 Regulation ZNF490 TNF 20577653 1911480 Regulation ZNF491 TNF 20577653 1911481 Regulation ZNF492 TNF 20577653 1911482 Regulation ZNF493 TNF 20577653 1911483 Regulation ZNF496 TNF 20577653 1911484 Regulation ZNF497 TNF 20577653 1911485 Regulation ZNF500 TNF 20577653 1911486 Regulation ZNF501 TNF 20577653 1911487 Regulation ZNF502 TNF 20577653 1911488 Regulation ZNF503 TNF 20577653 1911478 Regulation ZNF506 TNF 20577653 1911489 Regulation ZNF507 TNF 20577653 1911490 Regulation ZNF510 TNF 20577653 1911636 Regulation ZNF511 TNF 20577653 1911610 Regulation ZNF512 TNF 20577653 1911643 Regulation ZNF513 TNF 20577653 1911555 Regulation ZNF514 TNF 20577653 1911529 Regulation ZNF516 TNF 20577653 1911629 Regulation ZNF517 TNF 20577653 1911590 Regulation ZNF519 TNF 20577653 1911660 Regulation ZNF521 TNF 20577653 1911491 Regulation ZNF524 TNF 20577653 1911605 Regulation ZNF525 TNF 20577653 1911649 Regulation ZNF526 TNF 20577653 1911647 Regulation ZNF527 TNF 20577653 1911645 Regulation ZNF528 TNF 20577653 1911644 Regulation ZNF529 TNF 20577653 1911642 Regulation ZNF530 TNF 20577653 1911641 Regulation ZNF532 TNF 20577653 1911664 Regulation ZNF534 TNF 20577653 1911541 Regulation ZNF536 TNF 20577653 1911633 Regulation ZNF540 TNF 20577653 1911511 Regulation ZNF541 TNF 20577653 1911510 Regulation ZNF542 TNF 20577653 1911515 Regulation ZNF543 TNF 20577653 1911508 Regulation ZNF544 TNF 20577653 1911398 Regulation ZNF546 TNF 20577653 1911617 Regulation ZNF547 TNF 20577653 1911549 Regulation ZNF548 TNF 20577653 1911556 Regulation ZNF549 TNF 20577653 1911559 Regulation ZNF550 TNF 20577653 1911614 Regulation ZNF551 TNF 20577653 1911502 Regulation ZNF552 TNF 20577653 1911536 Regulation ZNF554 TNF 20577653 1911558 Regulation ZNF555 TNF 20577653 1911608 Regulation ZNF556 TNF 20577653 1911519 Regulation ZNF557 TNF 20577653 1911613 Regulation ZNF558 TNF 20577653 1911547 Regulation ZNF559 TNF 20577653 1911602 Regulation ZNF56 TNF 20577653 1911342 Regulation ZNF560 TNF 20577653 1911553 Regulation ZNF561 TNF 20577653 1911619 Regulation ZNF562 TNF 20577653 1911533 Regulation ZNF563 TNF 20577653 1911657 Regulation ZNF564 TNF 20577653 1911672 Regulation ZNF565 TNF 20577653 1911563 Regulation ZNF566 TNF 20577653 1911530 Regulation ZNF567 TNF 20577653 1911620 Regulation ZNF568 TNF 20577653 1911514 Regulation ZNF569 TNF 20577653 1911493 Regulation ZNF57 TNF 20577653 1911343 Regulation ZNF570 TNF 20577653 1911544 Regulation ZNF571 TNF 20577653 1911499 Regulation ZNF572 TNF 20577653 1911565 Regulation ZNF573 TNF 20577653 1911545 Regulation ZNF574 TNF 20577653 1911537 Regulation ZNF575 TNF 20577653 1911584 Regulation ZNF576 TNF 20577653 1911607 Regulation ZNF577 TNF 20577653 1911618 Regulation ZNF578 TNF 20577653 1911550 Regulation ZNF579 TNF 20577653 1911560 Regulation ZNF580 TNF 20577653 1911652 Regulation ZNF581 TNF 20577653 1911500 Regulation ZNF582 TNF 20577653 1911546 Regulation ZNF583 TNF 20577653 1911548 Regulation ZNF584 TNF 20577653 1911582 Regulation ZNF586 TNF 20577653 1911532 Regulation ZNF587 TNF 20577653 1911670 Regulation ZNF589 TNF 20577653 1911397 Regulation ZNF592 TNF 20577653 1911628 Regulation ZNF593 TNF 20577653 1911665 Regulation ZNF594 TNF 20577653 1911646 Regulation ZNF595 TNF 20577653 1911576 Regulation ZNF596 TNF 20577653 1911580 Regulation ZNF597 TNF 20577653 1911557 Regulation ZNF598 TNF 20577653 1911599 Regulation ZNF599 TNF 20577653 1911543 Regulation ZNF600 TNF 20577653 1911668 Regulation ZNF605 TNF 20577653 1911597 Regulation ZNF606 TNF 20577653 1911526 Regulation ZNF607 TNF 20577653 1911601 Regulation ZNF608 TNF 20577653 1911638 Regulation ZNF609 TNF 20577653 1911630 Regulation ZNF610 TNF 20577653 1911561 Regulation ZNF611 TNF 20577653 1911624 Regulation ZNF613 TNF 20577653 1911523 Regulation ZNF614 TNF 20577653 1911492 Regulation ZNF615 TNF 20577653 1911494 Regulation ZNF616 TNF 20577653 1911595 Regulation ZNF618 TNF 20577653 1911648 Regulation ZNF619 TNF 20577653 1911570 Regulation ZNF620 TNF 20577653 1911623 Regulation ZNF621 TNF 20577653 1911497 Regulation ZNF622 TNF 20577653 1911671 Regulation ZNF623 TNF 20577653 1911634 Regulation ZNF624 TNF 20577653 1911639 Regulation ZNF625 TNF 20577653 1911659 Regulation ZNF626 TNF 20577653 1911654 Regulation ZNF627 TNF 20577653 1911658 Regulation ZNF628 TNF 20577653 1911594 Regulation ZNF629 TNF 20577653 1911632 Regulation ZNF630 TNF 20577653 1911626 Regulation ZNF638 TNF 20577653 1911403 Regulation ZNF639 TNF 20577653 1911667 Regulation ZNF641 TNF 20577653 1911673 Regulation ZNF644 TNF 20577653 1911637 Regulation ZNF645 TNF 20577653 1911542 Regulation ZNF646 TNF 20577653 1911631 Regulation ZNF648 TNF 20577653 1911405 Regulation ZNF649 TNF 20577653 1911521 Regulation ZNF652 TNF 20577653 1911635 Regulation ZNF653 TNF 20577653 1911506 Regulation ZNF654 TNF 20577653 1911518 Regulation ZNF655 TNF 20577653 1911662 Regulation ZNF658 TNF 20577653 1911507 Regulation ZNF66 TNF 20577653 1911345 Regulation ZNF660 TNF 20577653 1911562 Regulation ZNF662 TNF 20577653 1911674 Regulation ZNF663 TNF 20577653 1911512 Regulation ZNF664 TNF 20577653 1911516 Regulation ZNF665 TNF 20577653 1911528 Regulation ZNF667 TNF 20577653 1911625 Regulation ZNF668 TNF 20577653 1911522 Regulation ZNF669 TNF 20577653 1911520 Regulation ZNF670 TNF 20577653 1911600 Regulation ZNF671 TNF 20577653 1911540 Regulation ZNF672 TNF 20577653 1911538 Regulation ZNF674 TNF 20577653 1911402 Regulation ZNF675 TNF 20577653 1911661 Regulation ZNF676 TNF 20577653 1911422 Regulation ZNF677 TNF 20577653 1911622 Regulation ZNF678 TNF 20577653 1911616 Regulation ZNF679 TNF 20577653 1911615 Regulation ZNF680 TNF 20577653 1911569 Regulation ZNF681 TNF 20577653 1911551 Regulation ZNF682 TNF 20577653 1911627 Regulation ZNF683 TNF 20577653 1911611 Regulation ZNF684 TNF 20577653 1911609 Regulation ZNF687 TNF 20577653 1911640 Regulation ZNF688 TNF 20577653 1911656 Regulation ZNF689 TNF 20577653 1911505 Regulation ZNF69 TNF 20577653 1911346 Regulation ZNF691 TNF 20577653 1911592 Regulation ZNF692 TNF 20577653 1911534 Regulation ZNF695 TNF 20577653 1911669 Regulation ZNF696 TNF 20577653 1911525 Regulation ZNF697 TNF 20577653 1911675 Regulation ZNF699 TNF 20577653 1911495 Regulation ZNF7 TNF 20577653 1911347 Regulation ZNF70 TNF 20577653 1911348 Regulation ZNF700 TNF 20577653 1911509 Regulation ZNF701 TNF 20577653 1911517 Regulation ZNF703 CCND1 19330026 2125002 Regulation ZNF703 TNF 20577653 1911527 Regulation ZNF704 TNF 20577653 1911677 Regulation ZNF704 ZFP57 20169146 2441196 Regulation ZNF706 TNF 20577653 1911498 Regulation ZNF707 TNF 20577653 1911589 Regulation ZNF708 TNF 20577653 1911258 Regulation ZNF709 TNF 20577653 1911423 Regulation ZNF71 TNF 20577653 1911349 Regulation ZNF710 TNF 20577653 1911513 Regulation ZNF711 TNF 20577653 1911344 Regulation ZNF713 TNF 20577653 1911459 Regulation ZNF714 TNF 20577653 1911574 Regulation ZNF716 TNF 20577653 1911678 Regulation ZNF717 TNF 20577653 1911651 Regulation ZNF718 TNF 20577653 1911567 Regulation ZNF720 TNF 20577653 1911571 Regulation ZNF721 TNF 20577653 1911650 Regulation ZNF723 TNF 20577653 1911676 Regulation ZNF726 TNF 20577653 1911679 Regulation ZNF727 TNF 20577653 1911462 Regulation ZNF728 TNF 20577653 1911680 Regulation ZNF729 TNF 20577653 1911681 Regulation ZNF73 TNF 20577653 1911350 Regulation ZNF730 TNF 20577653 1911686 Regulation ZNF732 TNF 20577653 1911708 Regulation ZNF735 TNF 20577653 1911682 Regulation ZNF736 TNF 20577653 1911683 Regulation ZNF737 TNF 20577653 1911684 Regulation ZNF738 TNF 20577653 1911685 Regulation ZNF74 TNF 20577653 1911351 Regulation ZNF740 TNF 20577653 1911583 Regulation ZNF746 TNF 20577653 1911458 Regulation ZNF747 TNF 20577653 1911606 Regulation ZNF749 TNF 20577653 1911687 Regulation ZNF750 TNF 20577653 1911524 Regulation ZNF76 TNF 20577653 1911352 Regulation ZNF761 TNF 20577653 1911464 Regulation ZNF763 TNF 20577653 1911586 Regulation ZNF764 TNF 20577653 1911603 Regulation ZNF765 TNF 20577653 1911501 Regulation ZNF766 TNF 20577653 1911596 Regulation ZNF767 TNF 20577653 1911457 Regulation ZNF768 TNF 20577653 1911539 Regulation ZNF77 TNF 20577653 1911353 Regulation ZNF770 TNF 20577653 1911535 Regulation ZNF771 TNF 20577653 1911653 Regulation ZNF772 TNF 20577653 1911689 Regulation ZNF773 TNF 20577653 1911655 Regulation ZNF774 TNF 20577653 1911690 Regulation ZNF775 TNF 20577653 1911612 Regulation ZNF776 TNF 20577653 1911566 Regulation ZNF777 TNF 20577653 1911460 Regulation ZNF778 TNF 20577653 1911552 Regulation ZNF781 TNF 20577653 1911564 Regulation ZNF782 TNF 20577653 1911691 Regulation ZNF783 TNF 20577653 1911577 Regulation ZNF784 TNF 20577653 1911692 Regulation ZNF785 TNF 20577653 1911554 Regulation ZNF786 TNF 20577653 1911456 Regulation ZNF787 TNF 20577653 1911573 Regulation ZNF788 TNF 20577653 1911693 Regulation ZNF789 TNF 20577653 1911588 Regulation ZNF79 TNF 20577653 1911354 Regulation ZNF790 TNF 20577653 1911694 Regulation ZNF791 TNF 20577653 1911568 Regulation ZNF792 TNF 20577653 1911496 Regulation ZNF793 TNF 20577653 1911695 Regulation ZNF799 TNF 20577653 1911598 Regulation ZNF8 TNF 20577653 1911355 Regulation ZNF80 TNF 20577653 1911356 Regulation ZNF800 TNF 20577653 1911579 Regulation ZNF805 TNF 20577653 1911470 Regulation ZNF806 TNF 20577653 1911696 Regulation ZNF807 TNF 20577653 1911697 Regulation ZNF808 TNF 20577653 1911698 Regulation ZNF81 TNF 20577653 1911357 Regulation ZNF812 TNF 20577653 1911699 Regulation ZNF813 TNF 20577653 1911700 Regulation ZNF814 TNF 20577653 1911701 Regulation ZNF816 TNF 20577653 1911572 Regulation ZNF821 TNF 20577653 1911593 Regulation ZNF823 TNF 20577653 1911663 Regulation ZNF827 TNF 20577653 1911575 Regulation ZNF829 TNF 20577653 1911702 Regulation ZNF83 TNF 20577653 1911358 Regulation ZNF830 TNF 20577653 1911604 Regulation ZNF831 TNF 20577653 1911392 Regulation ZNF835 TNF 20577653 1911703 Regulation ZNF836 TNF 20577653 1911704 Regulation ZNF837 TNF 20577653 1911504 Regulation ZNF839 TNF 20577653 1911421 Regulation ZNF84 TNF 20577653 1911359 Regulation ZNF840 TNF 20577653 1911705 Regulation ZNF841 TNF 20577653 1911585 Regulation ZNF843 TNF 20577653 1911621 Regulation ZNF844 TNF 20577653 1911531 Regulation ZNF845 TNF 20577653 1911503 Regulation ZNF846 TNF 20577653 1911578 Regulation ZNF85 TNF 20577653 1911360 Regulation ZNF850 TNF 20577653 1911591 Regulation ZNF852 TNF 20577653 1911587 Regulation ZNF853 TNF 20577653 1911455 Regulation ZNF860 TNF 20577653 1911706 Regulation ZNF862 TNF 20577653 1911707 Regulation ZNF865 TNF 20577653 1911713 Regulation ZNF878 TNF 20577653 1911709 Regulation ZNF879 TNF 20577653 1911711 Regulation ZNF880 TNF 20577653 1911710 Regulation ZNF883 TNF 20577653 1911581 Regulation ZNF888 TNF 20577653 1911712 Regulation ZNF891 TNF 20577653 1911714 Regulation ZNF90 TNF 20577653 1911361 Regulation ZNF91 TNF 20577653 1911362 Regulation ZNF92 TNF 20577653 1911363 Regulation ZNF93 TNF 20577653 1911364 Regulation ZNF98 TNF 20577653 1911365 Regulation ZNF99 TNF 20577653 1911366 Regulation ZSWIM2 F2R 23242217 1928919 Negative_regulation A2M FUT4 2427760 61792 Unlike aprotinin , *inhibited* [alpha 2-macroglobulin] bound trypsin activity as well as free trypsin . Negative_regulation A2M IL1B 11466367 839951 In this study , it is analyzed how *inhibits* IL-6 induced transcriptional activation of the [alpha(2)-macroglobulin] promoter . Negative_regulation A2M IL1B 2452086 91088 The stimulation of [alpha 2-macroglobulin] and cysteine proteinase inhibitor synthesis by interleukin-6 was *inhibited* by in a dose dependent manner . Negative_regulation AANAT TNF 17014691 1629412 The transcription of [Aa-nat] , a gene encoding the key enzyme in melatonin biosynthesis , together with the synthesis of the melatonin precursor N-acetylserotonin , was *inhibited* by . Negative_regulation AANAT TNF 20586888 2303346 Corticosterone inhibits pineal NFKB leading to an enhancement of melatonin production , while *leads* to inhibition of [Aa-nat] transcription and the production of N-acetylserotonin in cultured glands . Negative_regulation ABCA1 ABCA12 23931754 2826660 Overexpression of in HeLa-ABCA1 cells *increased* the abundance and stability of [ABCA1] . Negative_regulation ABCA1 CAPN8 12511593 1038855 In an apparent positive feedback loop , apoA-I binds [ABCA1] , promotes lipid efflux , *inhibits* degradation , and leads to increased levels of ABCA1 . Negative_regulation ABCA1 IL1B 17135302 1716732 *attenuated* [ABCA1] promoter activity through an LXR ( liver X receptor ) -independent pathway , since IL-1beta did not alter the expression and activities of LXRalpha/beta , and deletion of the LXR responsive element from the ABCA1 promoter failed to reverse the IL-1beta effect . Negative_regulation ABCA1 IL1B 17135302 1716736 Thus our data provide strong evidence that ROS and NF-kappaB , but not LXR , mediate the *induced* downregulation of [ABCA1] via a novel transcriptional mechanism , which might play an important role of proinflammation in the alteration of lipid metabolism . Negative_regulation ABCA1 TNF 19913791 2224829 Here we examined the *role* of in [ABCA1] induction and tested the effects of lymphotoxin-alpha (LT) , another TNF family member , on macrophage ABCA1 levels . Negative_regulation ABCA1 TNF 20212278 2230044 *reduced* both [ABCA1] and SR-BI expression and impaired cholesterol efflux from partially differentiated adipocytes . Negative_regulation ABCA12 SGMS1 19429679 2101279 Inhibitors of glucosylceramide synthase , , and ceramidase and small interfering RNA knockdown of human alkaline ceramidase , which all increase endogenous ceramide levels , also *increased* [ABCA12] mRNA levels . Negative_regulation ABCA12 SGMS2 19429679 2101278 Inhibitors of glucosylceramide synthase , , and ceramidase and small interfering RNA knockdown of human alkaline ceramidase , which all increase endogenous ceramide levels , also *increased* [ABCA12] mRNA levels . Negative_regulation ABCA12 UGCG 19429679 2101277 Inhibitors of , sphingomyelin synthase , and ceramidase and small interfering RNA knockdown of human alkaline ceramidase , which all increase endogenous ceramide levels , also *increased* [ABCA12] mRNA levels . Negative_regulation ABCA4 DMD 6740670 39595 and but not DMI *caused* small reductions of [RMP] , Vmax , and ERP . Negative_regulation ABCA4 NAPA 1381010 196027 *caused* a small but not significant concentration dependent decrease in Vmax , no change in [RMP] , and significant concentration dependent increases in APD50 , APD90 , and ERP . Negative_regulation ABCA4 PRKACB 16885524 1625607 However , the D ( 2 ) R effects on inward rectification and [RMP] were *blocked* by inhibition of PI-PLC , but not activity . Negative_regulation ABCA4 PRKACG 16885524 1625608 However , the D ( 2 ) R effects on inward rectification and [RMP] were *blocked* by inhibition of PI-PLC , but not activity . Negative_regulation ABCA4 PRKAR1A 16885524 1625609 However , the D ( 2 ) R effects on inward rectification and [RMP] were *blocked* by inhibition of PI-PLC , but not activity . Negative_regulation ABCA4 PRKAR1B 16885524 1625610 However , the D ( 2 ) R effects on inward rectification and [RMP] were *blocked* by inhibition of PI-PLC , but not activity . Negative_regulation ABCA4 PRKAR2A 16885524 1625611 However , the D ( 2 ) R effects on inward rectification and [RMP] were *blocked* by inhibition of PI-PLC , but not activity . Negative_regulation ABCA4 PRKAR2B 16885524 1625612 However , the D ( 2 ) R effects on inward rectification and [RMP] were *blocked* by inhibition of PI-PLC , but not activity . Negative_regulation ABCB1 FOXO1 18390843 1951284 *Role* of activation in [MDR1] expression in adriamycin-resistant breast cancer cells . Negative_regulation ABCB1 PTGER2 16415092 1533844 The *role* of dependent signaling via cAMP in [Mdr1b] gene activation in primary rat hepatocyte cultures . Negative_regulation ABCB1 RAB31 22863995 2682443 Moreover , quantitative real-time polymerase chain reaction ( qPCR ) analysis showed could *reduce* the transcript level of [MDR1] , a multidrug efflux pump , and caused a slight transcriptional reduction for another drug pump related gene CDR1 . Negative_regulation ABCB11 IL1B 17916651 1830233 In conclusion , zonal downregulation of [Bsep] in obstructive cholestasis is associated with portal inflammation and is *mediated* by TNF-alpha and . Negative_regulation ABCB11 TNF 15860642 1464963 *induces* a sustained decrease in Ntcp , Oatp1/Oatp1a1 , and [Bsep] mRNA expression but exerts only transient [ multidrug resistance associated protein 2 ( Mrp2 ) ] or no effects ( Mrp3 ) on Mrps . Negative_regulation ABCB11 TNF 17916651 1830232 In conclusion , zonal downregulation of [Bsep] in obstructive cholestasis is associated with portal inflammation and is *mediated* by and IL-1beta . Negative_regulation ABCB11 TNF 19074973 2035853 , unlike IL-6 , markedly *reduced* [bile salt export pump] mRNA levels and increased BCRP protein expression . Negative_regulation ABCC1 FOXO1 23763570 2882284 This study aimed to investigate the *role* of in regulating [MRP2] gene expression in TAMR-MCF-7 cells . Negative_regulation ABCC1 IL1B 15185298 1256162 *represses* [MRP2] gene expression through inactivation of interferon regulatory factor 3 in HepG2 cells . Negative_regulation ABCC1 IL1B 15185298 1256163 inhibited the transcriptional activity of MRP2 promoter constructs by 40 % , and this inhibition of [MRP2] promoter activity was *mediated* through the interferon stimulatory response element ( ISRE ) . Negative_regulation ABCC1 TNF 20702406 2323261 In SC human hepatocytes , both absolute protein and mRNA levels of [MRP2/ABCC2] were significantly *down-regulated* by , IL-6 , or IL-1ß . Negative_regulation ABCC2 TNF 20702406 2323264 In SC human hepatocytes , both absolute protein and mRNA levels of [MRP2/ABCC2] were significantly *down-regulated* by , IL-6 , or IL-1ß . Negative_regulation ABCC6 MAP2K6 17260025 1747264 beta2AR antagonists and constitutively active Mek-1 rescue from the effects of ARA-211 , demonstrating that beta2AR stimulation and kinase inhibition are *required* for [ARA-211] antitumor activity . Negative_regulation ABCG1 CAPN8 21295304 2410264 Here , we show the *role* of in [ABCG1] degradation . Negative_regulation ABCG1 TNF 23914732 2830652 Our results showed that *inhibited* the rate of cholesterol efflux and down-regulation the expression levels of ABCA1 , [ABCG1] and LXRa and up-regulation the expression levels of CD-36 , SR-A in human macrophages ; Negative_regulation ABCG2 ABCB1 23065516 2793533 ABCB1 ( ) and [ABCG2] *inhibitors* neither increased dasatinib intracellular concentration nor enhanced dasatinib mediated Bcr-Abl kinase inhibition . Negative_regulation ABCG2 AHR 24389113 2912001 inhibitors like CH223191 significantly reversed TCDD- and prochloraz *induced* stimulation of [ABCG2] efflux activity . Negative_regulation ABCG2 BCRP1 21602547 2445748 In placentae derived from female fetuses , high-dose DEX significantly downregulated [Abcg2] mRNA expression on E15 .5 ( P < .05 ) and significantly *inhibited* function ( P < .05 ) . Negative_regulation ABCG2 BSG 23622764 2784347 Further studies demonstrated that exogenous overexpression of in CHO cells *increased* [ABCG2] protein level . Negative_regulation ABCG2 CDH1 18245481 1865078 We conclude that ABCG2 expression in MCF7 cells is regulated during an EMT , and that the EMT effect reflects posttranslational regulation of ABCG2 function by as well as transcriptional *repression* of the [ABCG2] gene . Negative_regulation ABCG2 ERAS 21965746 2488301 induces chemoresistance to CPT-11 via activation of phosphatidylinositol-3 kinase-protein kinase ß mTOR pathway and NF-?B , and consequently *results* in up-regulation of [ABCG2] . Negative_regulation ABCG2 ESR1 18991020 2105755 However , response of the [ABCG2] promoter was *enhanced* by overexpression of in both T47D cells and BeWo cells . Negative_regulation ABCG2 MYLIP 22498306 2595558 significantly increased the chemosensitivity of ovarian CICs to cisplatin , pacitaxel , and adriamycin , and *reduced* mRNA expression of the multidrug resistance gene [ABCG2] as compared with miR-199a mutant transfected and untransfected cells . Negative_regulation ABCG2 MYLIP 23619912 2819091 Here , we report that *inhibits* the expression of CD133 , Lgr5 , and [ABCG2] in colon cancer cells by binding to both the 3'-untranslated region and the coding sequences of the three genes . Negative_regulation ABCG2 OSM 21570956 2445223 This *mediated* down-regulation of drug SLC transporters and [ABCG2] in human hepatocytes may contribute to alterations of pharmacokinetics in patients suffering from diseases associated with increased production of OSM . Negative_regulation ABCG2 PIM1 23261525 2732446 Decrease in ABCB1 and [ABCG2] cell surface expression *mediated* by inhibition represents a novel mechanism of chemosensitization . Negative_regulation ABCG2 PRL 23150485 2729611 We investigated the *role* of the lactogenic hormone in the regulation of [ABCG2] . Negative_regulation ABCG2 PTEN 19265662 2045553 In this cell population , Akt , but not its downstream target mTOR , regulates [ABCG2] activity , and loss of *increases* the SP . Negative_regulation ABCG2 SP1 23996530 2856093 The [ABCG2] promoter activity was impaired when Sp1 sites were mutated but was *enhanced* by overexpression of or Sp3 proteins . Negative_regulation ABI1 CAPN8 15178460 1255432 Taken together , these findings indicate that [E3b1] is *down-regulated* by activation and stabilized by Pak activation . Negative_regulation ACACA CCND1 14714130 1347038 To evaluate the *role* of in the biological regulation of [ACC] , we constitutively expressed an antisense cyclin D1 complementary DNA ( cDNA ) in an established ACC cell line that exhibits high endogenous expression of cyclin D1 . Negative_regulation ACACA PGC 21803289 2462265 Deletion of mIndy in mice ( mINDY ( -/- ) mice ) reduces hepatocellular ATP/ADP ratio , activates hepatic AMPK , induces , *inhibits* [ACC-2] , and reduces SREBP-1c levels . Negative_regulation ACAD8 EPHB2 19755425 2158579 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Negative_regulation ACAN EPHB2 16622376 1551686 Moreover , inhibition of activity , in the presence TGF-beta3 , *resulted* in suppression of collagen Type II , [aggrecan] , TGF-beta-RI , TGF-beta-RII and TGF-beta-RIII mRNA expression . Negative_regulation ACAN IL1B 11467894 840809 *suppressed* [aggrecan] synthesis by chondrocytes in agarose . Negative_regulation ACAN IL1B 19107653 2018865 FGF2 , , and TSA *inhibited* expression of [aggrecan] , while TSA also decreased mRNA levels of collagen type II . Negative_regulation ACAN IL1B 19714579 2139312 Transfection of chondrocytes with ds-miR-140 down-regulated IL-1beta induced ADAMTS5 expression and rescued the *dependent* repression of [AGGRECAN] gene expression . Negative_regulation ACAN IL1B 19763723 2247720 In vitro , muscone reversed *induced* upregulation of IL-1beta , tumor necrosis factor alpha , cyclooxygenase 2 , inducible nitric oxide synthase , matrix metalloproteinase 13 , aggrecanase 2 , and nitric oxide and downregulation of Col2alpha1 and [aggrecan] . Negative_regulation ACAN IL1B 21856929 2496232 Platelet-rich plasma releasate diminished *induced* inhibition of COL2A1 and [ACAN] gene expression . Negative_regulation ACAN IL1B 9645953 514924 Compressive force promotes sox9 , type II collagen and [aggrecan] and *inhibits* expression resulting in chondrogenesis in mouse embryonic limb bud mesenchymal cells . Negative_regulation ACAN MAP2K6 19762915 2158836 CA Akt also promoted type II collagen and Sox9 expression , whereas tBHP treatment and CA *inhibited* [aggrecan] , collagen II , and Sox9 mRNA expression . Negative_regulation ACAN MMP28 23797671 2815511 Exposure of the explants to recombinant hTryptase-ß , recombinant mMCP-6 , or lysates harvested from WT mouse peritoneal MCs ( PMCs ) significantly increased the levels of enzymatically active in cartilage and significantly *induced* [aggrecan] loss into the conditioned media , relative to replicate explants exposed to medium alone or lysates collected from mMCP-6-null PMCs . Negative_regulation ACAN MMP7 23797671 2815526 Exposure of the explants to recombinant hTryptase-ß , recombinant mMCP-6 , or lysates harvested from WT mouse peritoneal MCs ( PMCs ) significantly increased the levels of enzymatically active in cartilage and significantly *induced* [aggrecan] loss into the conditioned media , relative to replicate explants exposed to medium alone or lysates collected from mMCP-6-null PMCs . Negative_regulation ACAN TNF 15642133 1363095 Individually , and EGF *diminished* levels of [aggrecan] and type II collagen mRNA . Negative_regulation ACAN TNF 19026560 2001500 *suppressed* collagen type II and [aggrecan] , but increased MMP and cytokine expression in chondrocytes compared to the non stimulated controls . Negative_regulation ACCS JAG1 22427350 2588191 Analysis of clinical data indicates that Jag1 expression correlates with both grade and stage of ACCs , supporting a *role* of dependent Notch activation in late-stage [ACCs] . Negative_regulation ACD F2R 15078882 1251910 Concomitant stimulation of both and PAR-4 in the presence of ADP scavengers still *resulted* in a strongly reduced activation of [Rap1B] . Negative_regulation ACD TNF 10704256 672823 Moreover , removal of activity by a neutralizing anti-TNF-alpha antibody ( cA2 ) *restored* [Fas-ACD] . Negative_regulation ACD TNF 10704256 672825 These results suggest the following : ( 1 ) [Fas-ACD] might be *diminished* in vivo by local excessive and this might contribute in part to RASH . Negative_regulation ACE AGR2 20488233 2288729 The experimental results demonstrated the antihypertensive effect of Salvia elegans and it was due to the antagonism and *inhibition* of [angiotensin converting enzyme] . Negative_regulation ACE ANGPT1 2147739 145502 Systemic blood pressure did not change throughout the trial , indicating that no major systemic effects were present during infusion or concomitant [ACE] *inhibition* . Negative_regulation ACE ANGPT1 8840953 386869 The circulating and urinary bladder tissue concentrations of angiotensin I (ANG I) and angiotensin II [ANG- ( 1-8 ) ] were examined in anesthetized Sprague-Dawley male rats given an intravenous bolus infusion of either , the [angiotensin converting enzyme (ACE)] *inhibitors* enalaprilat or ramiprilat , or saline . Negative_regulation ACE ANGPT1 9281434 451466 Ang II content in pouch tissue was measured by radioimmunoassay following HPLC separation while its capacity to generate Ang II was assessed in tissue bath , with and without exogenous or lisinopril , an [ACE] *inhibitor* . Negative_regulation ACE ANGPT1 9655885 516619 *inhibited* purified [angiotensin converting enzyme (ACE)] by 30 +/- 3.5 % ( n = 4 ) at 10 ( -6 ) M . Negative_regulation ACE ARSA 12596445 1029850 Some agents are probably underemployed ( [ACE] *inhibitors* , ) and others overused ( antiulcerous ) . Negative_regulation ACE ARSA 16674817 1569824 The exposure to cardioprotective drugs was defined as the number of cardioprotective drug classes ( , Beta-Blockers , [Angiotensin Converting Enzyme (ACE)] *Inhibitors* , Statins ) claimed within the index period ( first 30 days after the index hospitalization ) . Negative_regulation ACE ARSA 18180914 1870052 Dispensed drugs after AMI were compared to the recommended drug treatment according to Swedish and European guidelines -- , beta-blockers , lipid lowering drugs and angiotensin converting enzyme inhibitors ( [ACE] *inhibitors* ) . Negative_regulation ACE ARSA 19653115 2180278 Patients with severe LVDys ( EF < 40 % ) were more likely to be prescribed [angiotensin converting enzyme] *inhibitors* ( 55.8 vs. 39.1 % , P = 0.051 ) , beta-blockers ( 81.4 vs. 62.4 % , P = 0.018 ) , statins ( 60.5 vs 38.3 % , P = 0.009 ) , ( 37.2 vs 21 % , P = 0.27 ) and clopidogrel ( 16.3 vs. 3 % , P = 0.001 ) . Negative_regulation ACE EDN2 15320512 1286514 Treatment with [ACE] *inhibitors* , angiotensin- , aldosterone- , and has been shown to beneficially modulate endothelial dysfunction in CHF . Negative_regulation ACE EDN2 8707380 376344 Comparison of effect of antagonism and [angiotensin converting enzyme] *inhibition* on blood pressure and vascular structure in spontaneously hypertensive rats treated with N omega-nitro-L-arginine methyl ester . Negative_regulation ACE EDN2 9595459 506032 Effects of receptor antagonism and [angiotensin converting enzyme] *inhibition* on cardiac and renal remodeling in the rat . Negative_regulation ACE MMP28 10525103 653915 This study examined the effects of specific inhibition , [ACE] *inhibition* , and combined treatment on LV systolic and diastolic function in a model of CHF . Negative_regulation ACE MMP7 10525103 653930 This study examined the effects of specific inhibition , [ACE] *inhibition* , and combined treatment on LV systolic and diastolic function in a model of CHF . Negative_regulation ACE TLR7 24251781 2903614 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , PI3K/AkT inhibition , IKK/JNK inhibition , mTORC1 inhibition , JAK/STAT inhibition , suppression , and [ACE] *inhibition* . Negative_regulation ACE TNF 20452384 2288460 *repressed* the expression of [ACE] in HUVECs while phorbol 12-myristate 13-acetate ( PMA ) upregulated it in 24h ( approximately 12-fold dynamic range by [ ( 3 ) H ] enalaprilat binding , corroborated by ACE immunoblotting ) . Negative_regulation ACE2 ANGPT1 23681967 2827843 With the exception of the lowest rhACE2 dose , the decrease in levels lasted for at least 24 h. Repeated dosing ( 400 µg/kg for 3 or 6 days ) *caused* only minimal accumulation of [ACE2] , and Ang1-8 levels were suppressed over the whole application period . Negative_regulation ACHE FAS 10741458 679930 However , , at concentrations in which changes of morphological parameters were observed , did not *inhibit* the [AChE] activity as measured histochemically . Negative_regulation ACHE FAS 1823265 177831 1. We examined the effect , in rats , of an intraseptal microinjection of , an irreversible peptide [acetylcholinesterase (AChE)] *inhibitor* , on a ) AChE activity measured in septum and hippocampus , b ) 3H-quinuclidinyl benzylate ( 3H-QNB ) and 3H-oxotremorine ( 3H-OXO ) binding to hippocampal cholinergic muscarinic receptors , c ) 3H-flunitrazepam ( 3H-FNZ ) binding to hippocampal benzodiazepine receptors as a control for QNB and OXO binding , d ) acquisition and retention in three different behavioral paradigms , i.e. , water finding ( in which there is concomitant habituation to the apparatus ) , step-down inhibitory avoidance , and shuttle avoidance . Negative_regulation ACHE FAS 7528787 284158 In order to examine the ability of motor neurones to take up fasciculin (FAS) and transport it centrally from muscle terminals to the spinal cord , we injected pure 2 , a powerful [acetylcholinesterase (AChE)] *inhibitor* , into mouse gastrocnemius muscle . Negative_regulation ACHE FAS 7689409 225746 The effects of the peptide , a potent *inhibitor* of [acetylcholinesterase (AChE)] have been examined , following unilateral microinfusion , on tissue levels of monoamines in the rat substantia nigra and concomitant circling behaviour . Negative_regulation ACHE FAS 7689409 225747 Although *inhibited* 87 % of total [AChE] , the levels of dopamine and its metabolites remained unchanged . Negative_regulation ACHE FAS 8509385 221629 All the specific binding of 125I-FAS3 to [AChE] is *prevented* by as from D. angusticeps venom ( Kd = 0.4 , 14 , and 25 pM , respectively ) . Negative_regulation ACHE MAOA 19943334 2264467 Methanolic extracts of the plants were tested for protective effects against hydrogen-peroxide induced toxicity in PC12 cells , antioxidant activity ( by ABTS and X/XO methods ) and neurochemical properties ( inhibition , [AChE] *inhibition* and affinity to the GABA(A) receptor ) . Negative_regulation ACHE MAOA 23261030 2724838 Taken together , our findings established molecular details of [AChE] , BChE and *inhibition* by quaternary ß-carboline alkaloids and MIAs from Psychotria , suggesting these secondary metabolites are scaffolds for the development of multifunctional compounds against neurodegeneration . Negative_regulation ACO1 IL1B 1720090 171636 The presence of actinomycin-D during the 1-h IL-1 beta incubation period prevented the *induced* rise in nitrite production and the IL-1 beta induced inhibition of [aconitase] activity and insulin release . Negative_regulation ACO2 IL1B 1731791 181381 induces nitric oxide production and *inhibits* the activity of [aconitase] without decreasing glucose oxidation rates in isolated mouse pancreatic islets . Negative_regulation ACO2 IL1B 1731791 181382 It is concluded that in both rat and mouse islets induces nitric oxide formation and that this induction *leads* to the inhibition of the Krebs cycle enzyme [aconitase] . Negative_regulation ACO2 IL1B 7514870 257080 Inhibition of NO synthase also restores *induced* inhibition of mitochondrial [aconitase] activity in a time dependent fashion that mimics the recovery of glucose stimulated insulin secretion by islets . Negative_regulation ACP2 TNF 23509807 2756988 NaO induced BNBD4 , [LAP] , and BNBD10 mRNA expression , but BNBD5 and were *inhibited* . Negative_regulation ACR JAG1 3304435 76575 To determine if these can contact sperm and *inhibit* [acrosin] when mixed with the entire human ejaculate for a short period of time ( roughly imitating clinical conditions ) , the inhibitors were added to semen at various concentrations for 2 min , after which the seminal plasma and unbound inhibitor were removed from the sperm by Ficoll centrifugation . Negative_regulation ACSL3 FAS 15556626 1340231 Triacsin C , an inhibitor of FACL3 activity , completely abolished the downregulation of FAS expression by vitamin D3 , whereas an inhibitor of activity , cerulenin , *had* no significant effect on the upregulation of [FACL3] expression by vitamin D3 in LNCaP cells . Negative_regulation ACSS1 ACLY 22718913 2659538 Furthermore , suppression *resulted* in elevated expression of [acyl-CoA synthetase short-chain family] member 2 ( ACSS2 ) , an enzyme that also produces acetyl-CoA using acetate as a substrate . Negative_regulation ACSS1 STS 16315594 1487395 As an ethylene action inhibitor , at concentration of 0.2 mmol/L generally *inhibited* the expression of [Rh-ACSs] and Rh-ACO in both cultivars , although it induced the expression of Rh-ACS3 transiently in ` Kardinal ' . Negative_regulation ACSS2 EDN2 9230761 444744 To investigate the *role* of the endothelial derived vasoactive mediator ( ET-1 ) in the [acute chest syndrome (ACS)] , we incubated bovine pulmonary artery endothelial cells ( BPAEC ) with red blood cells ( equivalent to a hematocrit of 20 % ) and/or autologous plasma ( 1 : 10 dilution ) from two patients during ACS and during routine clinic visits . Negative_regulation ACTB TNF 8375478 229876 These data suggested that the *induced* inhibition of [beta-actin] gene expression was not due to altered transcription activity . Negative_regulation ACTC1 TNF 3405207 96200 When added to proliferating myoblasts , *inhibited* the expression of [alpha-cardiac actin] , a muscle-specific gene whose expression is observed at low levels in human myoblasts . Negative_regulation ACVRL1 EPHB2 17620321 1787018 Further , HMVEC-d wounding induced activation of both JNK and , and these were *inhibited* by [ALK1ca] expression . Negative_regulation ADA NT5E 11961376 932600 In pregnant women , the activity of plasma <5'-nucleotidase> and plasma [ADO ] were significantly elevated and plasma [adenosine deaminase] activity was significantly *reduced* . Negative_regulation ADAM11 EPHB2 17617806 1769753 The suppressive effect on [MDC] and IP-10 may , at least in part , *involve* the down-regulation of LPS induced p38 and expression . Negative_regulation ADAM11 JAG1 20974985 2348713 Upregulation of OX40L and by mDC *resulted* in [mDC-driven] Th2 responses . Negative_regulation ADAM17 CLU 16213748 1501088 Among these 30 genes we found a high proportion of genes associated with apoptotic cell death , cell proliferation and cell cycle signalling including complement lysis *inhibitor* ( ) , beta-catenin interacting protein ( ICAT ) , peroxisome proliferator activated receptor alpha ( PPARalpha ) , [TNF alpha converting enzyme] ( ADAM17/TACE ) , homeo box A3 ( HOX1 ) , inositol polyphosphatase 5-phosphatase type IV ( PPI5PIV ) and inhibitor of p53 induced apoptosis alpha ( IPIA-Alpha/NM23-H6 ) . Negative_regulation ADAM17 TNF 12014967 941737 The best compound inhibits MMPs and [TACE] with nanomolar potency and *inhibits* the release of from cells with an IC50 of 48 nM . Negative_regulation ADAM17 TNF 12973924 1139665 It was concluded that all the three types of TACE inhibitors can regulate the expression of [TACE] at different levels and *inhibit* secretion , indicating TACE is a novel target for inflammation therapy . Negative_regulation ADAM17 TNF 15145598 1247696 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of MMP and [TACE] , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation ADAM17 TNF 21078557 2349627 Twelve analogues were synthesized and most of compounds were active in vitro [TACE] enzyme inhibition as well as cellular *inhibition* . Negative_regulation ADAM8 CST6 20116077 2226762 While both enzymes are inhibited by E-64 and iodoacetamide , chicken fully *inhibits* [CMS1MS2] , but scarcely affects activity of CMS2MS2 . Negative_regulation ADAMTS1 FBLN1 16061471 1460145 Furthermore , was found to *enhance* the capacity of [ADAMTS-1] to cleave aggrecan , a proteoglycan known to bind to fibulin-1 . Negative_regulation ADAMTS1 HDAC1 19007777 1998205 inhibition *upregulates* the expression of angiostatic [ADAMTS1] . Negative_regulation ADAMTS1 HDAC2 19007777 1998206 inhibition *upregulates* the expression of angiostatic [ADAMTS1] . Negative_regulation ADAMTS1 MMP3 15208368 1267956 Studies were designed to determine if ADAMTS-1 ( a disintegrin and metalloproteinase with thrombospondin repeats-1 ) is expressed in the rhesus monkey corpus luteum ( CL ) , is regulated by endocrine ( LH ) or local ( progesterone ) factors , and is correlated with tissue inhibitor of ( TIMP-3 ) , an *inhibitor* of [ADAMTS-1] . Negative_regulation ADAMTS1 RBBP4 19007777 1998207 inhibition *upregulates* the expression of angiostatic [ADAMTS1] . Negative_regulation ADAMTS1 RBBP7 19007777 1998208 inhibition *upregulates* the expression of angiostatic [ADAMTS1] . Negative_regulation ADAMTS1 SMARCA4 18267097 1865726 We show that trabeculation *requires* , a chromatin remodeling protein , to repress [ADAMTS1] expression in the endocardium that overlies the developing trabeculae . Negative_regulation ADAMTS4 IL1B 15805962 1391024 In the *presence* of , the strain reduced the mRNA levels of [aggrecanase-1] and aggrecanase-2 . Negative_regulation ADAMTS5 IL1B 15805962 1391025 In the presence of , the strain *reduced* the mRNA levels of aggrecanase-1 and [aggrecanase-2] . Negative_regulation ADAP1 F2R 16341594 1491826 p42 ( IP4 ) [/centaurin alpha1] , a brain-specific PtdIns ( 3,4,5 ) P3/Ins ( 1,3,4,5 ) P4-binding protein : membrane trafficking induced by epidermal growth factor is *inhibited* by stimulation of phospholipase C-coupled . Negative_regulation ADCY1 ADRB2 9271340 450263 In previous studies , it was shown that the overexpression of in the hearts of transgenic mice ( Tg ) *leads* to agonist independent activation of [adenylate cyclase] and enhanced myocardial function . Negative_regulation ADCY1 CA12 233968 1087 The inhibitory effect of PTH was ATP- , Mg++- , and K+-dependent and temperature dependent ; inactivation of PTH by heating at 100degreesC abolished the effect of PTH both to activate [adenylate cyclase] and to *inhibit* . Negative_regulation ADCY1 CA12 233968 1347 Calcium 5 mM also partially abolished effects of PTH to activate [adenylate cyclase] and to *inhibit* . Negative_regulation ADCY1 EDN2 1316904 185750 *inhibits* [adenylate cyclase] and stimulates phosphoinositide hydrolysis in adult cardiac myocytes . Negative_regulation ADCY1 GPR115 7684247 216736 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY1 GPR132 7684247 216725 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY1 GPR87 7684247 216805 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY1 MAOA 3234480 103046 These data suggest that chronic nonselective and chronic inhibition *causes* a down-regulation of the 5-HT1A mediated inhibition of forskolin stimulated [adenylate cyclase] activity . Negative_regulation ADCY1 MAP2K6 8071375 270341 Both mutant PAF receptors more potently activated the other signals ( , arachidonate release , and *inhibition* of [adenylate cyclase] ) than did the wild type receptor . Negative_regulation ADCY1 PTGER2 1667331 176564 In conclusion , activation of protein kinase C by phorbol esters reveals a Gi-mediated *induced* inhibition of [adenylate cyclase] in addition to the prostaglandin E receptor mediated stimulation of cAMP accumulation in Jurkat cells . Negative_regulation ADCY1 RASD1 15913563 1412591 Acute D ( 2L ) receptor mediated inhibition of A23187 stimulated [AC1] activity ( IC50 , 4.0+/-1.4 nM ; 50+/-3 % inhibition ) was not altered in the *presence* of ( IC50 , 2.4+/-1.3 nM , 50+/-1 % inhibition ) ; Negative_regulation ADCY1 S100B 18445708 1938541 and 5 ) coexpression of in D ( 2 ) receptor expressing 293 cells selectively *increased* D ( 2 ) receptor stimulation of extracellular signal regulated kinases and inhibition of [adenylate cyclase] . Negative_regulation ADCY1 S100B 3191991 101170 *inhibits* the [adenylate cyclase] activity in the presence of Mg2+ ( 5.0-50 mM ) , while it activates the same enzyme in the presence of Ca2+ ( 0.1-1.0 mM ) dose-dependently in both cases . Negative_regulation ADCY1 SELL 1521577 196970 Addition of the octapeptide , Met5-enk *resulted* in decreased [adenylate cyclase] activity ; Negative_regulation ADCY1 SRGN 2120055 141862 Hepatocytes from obese Zucker rats displayed a resistance to both agonist induced phosphorylation of alpha Gi-2 and to p [ NH ] *mediated* inhibition of [adenylate cyclase] . Negative_regulation ADCY1 SRGN 2511846 121774 The ability of p [ NH ] to *inhibit* forskolin stimulated [adenylate cyclase] activity was attenuated in the presence of insulin . Negative_regulation ADCY10 ADRB2 9271340 450262 In previous studies , it was shown that the overexpression of in the hearts of transgenic mice ( Tg ) *leads* to agonist independent activation of [adenylate cyclase] and enhanced myocardial function . Negative_regulation ADCY10 CA12 233968 1074 The inhibitory effect of PTH was ATP- , Mg++- , and K+-dependent and temperature dependent ; inactivation of PTH by heating at 100degreesC abolished the effect of PTH both to activate [adenylate cyclase] and to *inhibit* . Negative_regulation ADCY10 CA12 233968 1334 Calcium 5 mM also partially abolished effects of PTH to activate [adenylate cyclase] and to *inhibit* . Negative_regulation ADCY10 CA12 3136415 95866 Ultrastructural localization of and its possible *role* in the endolymphatic [sac] . Negative_regulation ADCY10 EDN2 1316904 185747 *inhibits* [adenylate cyclase] and stimulates phosphoinositide hydrolysis in adult cardiac myocytes . Negative_regulation ADCY10 FHL1 16407297 1533657 Overexpression of in differentiating C2C12 cells *induced* `` [sac-like] '' myotube formation ( myosac ) , associated with impaired Z-line and myosin thick filament assembly . Negative_regulation ADCY10 GPR115 7684247 216643 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY10 GPR132 7684247 216632 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY10 GPR87 7684247 216712 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY10 MAOA 3234480 103044 These data suggest that chronic nonselective and chronic inhibition *causes* a down-regulation of the 5-HT1A mediated inhibition of forskolin stimulated [adenylate cyclase] activity . Negative_regulation ADCY10 MAP2K6 8071375 270334 Both mutant PAF receptors more potently activated the other signals ( , arachidonate release , and *inhibition* of [adenylate cyclase] ) than did the wild type receptor . Negative_regulation ADCY10 PTGER2 1667331 176560 In conclusion , activation of protein kinase C by phorbol esters reveals a Gi-mediated *induced* inhibition of [adenylate cyclase] in addition to the prostaglandin E receptor mediated stimulation of cAMP accumulation in Jurkat cells . Negative_regulation ADCY10 S100B 18445708 1938540 and 5 ) coexpression of in D ( 2 ) receptor expressing 293 cells selectively *increased* D ( 2 ) receptor stimulation of extracellular signal regulated kinases and inhibition of [adenylate cyclase] . Negative_regulation ADCY10 S100B 3191991 101168 *inhibits* the [adenylate cyclase] activity in the presence of Mg2+ ( 5.0-50 mM ) , while it activates the same enzyme in the presence of Ca2+ ( 0.1-1.0 mM ) dose-dependently in both cases . Negative_regulation ADCY10 SELL 1521577 196967 Addition of the octapeptide , Met5-enk *resulted* in decreased [adenylate cyclase] activity ; Negative_regulation ADCY10 SRGN 2120055 141861 Hepatocytes from obese Zucker rats displayed a resistance to both agonist induced phosphorylation of alpha Gi-2 and to p [ NH ] *mediated* inhibition of [adenylate cyclase] . Negative_regulation ADCY10 SRGN 2511846 121773 The ability of p [ NH ] to *inhibit* forskolin stimulated [adenylate cyclase] activity was attenuated in the presence of insulin . Negative_regulation ADCY2 ADRB2 9271340 450264 In previous studies , it was shown that the overexpression of in the hearts of transgenic mice ( Tg ) *leads* to agonist independent activation of [adenylate cyclase] and enhanced myocardial function . Negative_regulation ADCY2 CA12 233968 1100 The inhibitory effect of PTH was ATP- , Mg++- , and K+-dependent and temperature dependent ; inactivation of PTH by heating at 100degreesC abolished the effect of PTH both to activate [adenylate cyclase] and to *inhibit* . Negative_regulation ADCY2 CA12 233968 1360 Calcium 5 mM also partially abolished effects of PTH to activate [adenylate cyclase] and to *inhibit* . Negative_regulation ADCY2 EDN2 1316904 185753 *inhibits* [adenylate cyclase] and stimulates phosphoinositide hydrolysis in adult cardiac myocytes . Negative_regulation ADCY2 GPR115 7684247 216829 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY2 GPR132 7684247 216818 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY2 GPR87 7684247 216898 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY2 MAOA 3234480 103048 These data suggest that chronic nonselective and chronic inhibition *causes* a down-regulation of the 5-HT1A mediated inhibition of forskolin stimulated [adenylate cyclase] activity . Negative_regulation ADCY2 MAP2K6 8071375 270348 Both mutant PAF receptors more potently activated the other signals ( , arachidonate release , and *inhibition* of [adenylate cyclase] ) than did the wild type receptor . Negative_regulation ADCY2 PTGER2 1667331 176568 In conclusion , activation of protein kinase C by phorbol esters reveals a Gi-mediated *induced* inhibition of [adenylate cyclase] in addition to the prostaglandin E receptor mediated stimulation of cAMP accumulation in Jurkat cells . Negative_regulation ADCY2 RASD1 16489124 1548664 In addition , significantly *reduced* phorbol 12-myristate 13-acetate ( PMA ) -stimulated [AC2] activity but did not alter Galpha ( s ) -mediated cAMP accumulation . Negative_regulation ADCY2 S100B 18445708 1938542 and 5 ) coexpression of in D ( 2 ) receptor expressing 293 cells selectively *increased* D ( 2 ) receptor stimulation of extracellular signal regulated kinases and inhibition of [adenylate cyclase] . Negative_regulation ADCY2 S100B 3191991 101172 *inhibits* the [adenylate cyclase] activity in the presence of Mg2+ ( 5.0-50 mM ) , while it activates the same enzyme in the presence of Ca2+ ( 0.1-1.0 mM ) dose-dependently in both cases . Negative_regulation ADCY2 SELL 1521577 196973 Addition of the octapeptide , Met5-enk *resulted* in decreased [adenylate cyclase] activity ; Negative_regulation ADCY2 SRGN 2120055 141863 Hepatocytes from obese Zucker rats displayed a resistance to both agonist induced phosphorylation of alpha Gi-2 and to p [ NH ] mediated *inhibition* of [adenylate cyclase] . Negative_regulation ADCY2 SRGN 2511846 121775 The ability of p [ NH ] to *inhibit* forskolin stimulated [adenylate cyclase] activity was attenuated in the presence of insulin . Negative_regulation ADCY3 ADRB2 9271340 450265 In previous studies , it was shown that the overexpression of in the hearts of transgenic mice ( Tg ) *leads* to agonist independent activation of [adenylate cyclase] and enhanced myocardial function . Negative_regulation ADCY3 CA12 233968 1113 The inhibitory effect of PTH was ATP- , Mg++- , and K+-dependent and temperature dependent ; inactivation of PTH by heating at 100degreesC abolished the effect of PTH both to activate [adenylate cyclase] and to *inhibit* . Negative_regulation ADCY3 CA12 233968 1373 Calcium 5 mM also partially abolished effects of PTH to activate [adenylate cyclase] and to *inhibit* . Negative_regulation ADCY3 EDN2 1316904 185756 *inhibits* [adenylate cyclase] and stimulates phosphoinositide hydrolysis in adult cardiac myocytes . Negative_regulation ADCY3 GPR115 7684247 216922 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY3 GPR132 7684247 216911 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY3 GPR87 7684247 216991 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY3 MAOA 3234480 103050 These data suggest that chronic nonselective and chronic inhibition *causes* a down-regulation of the 5-HT1A mediated inhibition of forskolin stimulated [adenylate cyclase] activity . Negative_regulation ADCY3 MAP2K6 8071375 270355 Both mutant PAF receptors more potently activated the other signals ( , arachidonate release , and *inhibition* of [adenylate cyclase] ) than did the wild type receptor . Negative_regulation ADCY3 PTGER2 1667331 176572 In conclusion , activation of protein kinase C by phorbol esters reveals a Gi-mediated *induced* inhibition of [adenylate cyclase] in addition to the prostaglandin E receptor mediated stimulation of cAMP accumulation in Jurkat cells . Negative_regulation ADCY3 S100B 18445708 1938543 and 5 ) coexpression of in D ( 2 ) receptor expressing 293 cells selectively *increased* D ( 2 ) receptor stimulation of extracellular signal regulated kinases and inhibition of [adenylate cyclase] . Negative_regulation ADCY3 S100B 3191991 101174 *inhibits* the [adenylate cyclase] activity in the presence of Mg2+ ( 5.0-50 mM ) , while it activates the same enzyme in the presence of Ca2+ ( 0.1-1.0 mM ) dose-dependently in both cases . Negative_regulation ADCY3 SELL 1521577 196976 Addition of the octapeptide , Met5-enk *resulted* in decreased [adenylate cyclase] activity ; Negative_regulation ADCY3 SRGN 2120055 141864 Hepatocytes from obese Zucker rats displayed a resistance to both agonist induced phosphorylation of alpha Gi-2 and to p [ NH ] *mediated* inhibition of [adenylate cyclase] . Negative_regulation ADCY3 SRGN 2511846 121776 The ability of p [ NH ] to *inhibit* forskolin stimulated [adenylate cyclase] activity was attenuated in the presence of insulin . Negative_regulation ADCY4 ADRB2 9271340 450266 In previous studies , it was shown that the overexpression of in the hearts of transgenic mice ( Tg ) *leads* to agonist independent activation of [adenylate cyclase] and enhanced myocardial function . Negative_regulation ADCY4 CA12 233968 1126 The inhibitory effect of PTH was ATP- , Mg++- , and K+-dependent and temperature dependent ; inactivation of PTH by heating at 100degreesC abolished the effect of PTH both to activate [adenylate cyclase] and to *inhibit* . Negative_regulation ADCY4 CA12 233968 1386 Calcium 5 mM also partially abolished effects of PTH to activate [adenylate cyclase] and to *inhibit* . Negative_regulation ADCY4 EDN2 1316904 185759 *inhibits* [adenylate cyclase] and stimulates phosphoinositide hydrolysis in adult cardiac myocytes . Negative_regulation ADCY4 GPR115 7684247 217015 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY4 GPR132 7684247 217004 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY4 GPR87 7684247 217084 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY4 MAOA 3234480 103052 These data suggest that chronic nonselective and chronic inhibition *causes* a down-regulation of the 5-HT1A mediated inhibition of forskolin stimulated [adenylate cyclase] activity . Negative_regulation ADCY4 MAP2K6 8071375 270362 Both mutant PAF receptors more potently activated the other signals ( , arachidonate release , and *inhibition* of [adenylate cyclase] ) than did the wild type receptor . Negative_regulation ADCY4 PTGER2 1667331 176576 In conclusion , activation of protein kinase C by phorbol esters reveals a Gi-mediated *induced* inhibition of [adenylate cyclase] in addition to the prostaglandin E receptor mediated stimulation of cAMP accumulation in Jurkat cells . Negative_regulation ADCY4 S100B 18445708 1938544 and 5 ) coexpression of in D ( 2 ) receptor expressing 293 cells selectively *increased* D ( 2 ) receptor stimulation of extracellular signal regulated kinases and inhibition of [adenylate cyclase] . Negative_regulation ADCY4 S100B 3191991 101176 *inhibits* the [adenylate cyclase] activity in the presence of Mg2+ ( 5.0-50 mM ) , while it activates the same enzyme in the presence of Ca2+ ( 0.1-1.0 mM ) dose-dependently in both cases . Negative_regulation ADCY4 SELL 1521577 196979 Addition of the octapeptide , Met5-enk *resulted* in decreased [adenylate cyclase] activity ; Negative_regulation ADCY4 SRGN 2120055 141865 Hepatocytes from obese Zucker rats displayed a resistance to both agonist induced phosphorylation of alpha Gi-2 and to p [ NH ] mediated *inhibition* of [adenylate cyclase] . Negative_regulation ADCY4 SRGN 2511846 121777 The ability of p [ NH ] to *inhibit* forskolin stimulated [adenylate cyclase] activity was attenuated in the presence of insulin . Negative_regulation ADCY5 ADRB2 9271340 450267 In previous studies , it was shown that the overexpression of in the hearts of transgenic mice ( Tg ) *leads* to agonist independent activation of [adenylate cyclase] and enhanced myocardial function . Negative_regulation ADCY5 CA12 233968 1139 The inhibitory effect of PTH was ATP- , Mg++- , and K+-dependent and temperature dependent ; inactivation of PTH by heating at 100degreesC abolished the effect of PTH both to activate [adenylate cyclase] and to *inhibit* . Negative_regulation ADCY5 CA12 233968 1399 Calcium 5 mM also partially abolished effects of PTH to activate [adenylate cyclase] and to *inhibit* . Negative_regulation ADCY5 EDN2 1316904 185762 *inhibits* [adenylate cyclase] and stimulates phosphoinositide hydrolysis in adult cardiac myocytes . Negative_regulation ADCY5 GPR115 7684247 217108 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY5 GPR132 7684247 217097 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY5 GPR87 7684247 217177 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY5 MAOA 3234480 103054 These data suggest that chronic nonselective and chronic inhibition *causes* a down-regulation of the 5-HT1A mediated inhibition of forskolin stimulated [adenylate cyclase] activity . Negative_regulation ADCY5 MAP2K6 8071375 270369 Both mutant PAF receptors more potently activated the other signals ( , arachidonate release , and *inhibition* of [adenylate cyclase] ) than did the wild type receptor . Negative_regulation ADCY5 PTGER2 1667331 176580 In conclusion , activation of protein kinase C by phorbol esters reveals a Gi-mediated *induced* inhibition of [adenylate cyclase] in addition to the prostaglandin E receptor mediated stimulation of cAMP accumulation in Jurkat cells . Negative_regulation ADCY5 S100B 18445708 1938545 and 5 ) coexpression of in D ( 2 ) receptor expressing 293 cells selectively *increased* D ( 2 ) receptor stimulation of extracellular signal regulated kinases and inhibition of [adenylate cyclase] . Negative_regulation ADCY5 S100B 3191991 101178 *inhibits* the [adenylate cyclase] activity in the presence of Mg2+ ( 5.0-50 mM ) , while it activates the same enzyme in the presence of Ca2+ ( 0.1-1.0 mM ) dose-dependently in both cases . Negative_regulation ADCY5 SELL 1521577 196982 Addition of the octapeptide , Met5-enk *resulted* in decreased [adenylate cyclase] activity ; Negative_regulation ADCY5 SRGN 2120055 141866 Hepatocytes from obese Zucker rats displayed a resistance to both agonist induced phosphorylation of alpha Gi-2 and to p [ NH ] mediated *inhibition* of [adenylate cyclase] . Negative_regulation ADCY5 SRGN 2511846 121778 The ability of p [ NH ] to *inhibit* forskolin stimulated [adenylate cyclase] activity was attenuated in the presence of insulin . Negative_regulation ADCY6 ADRB2 9271340 450268 In previous studies , it was shown that the overexpression of in the hearts of transgenic mice ( Tg ) *leads* to agonist independent activation of [adenylate cyclase] and enhanced myocardial function . Negative_regulation ADCY6 CA12 233968 1152 The inhibitory effect of PTH was ATP- , Mg++- , and K+-dependent and temperature dependent ; inactivation of PTH by heating at 100degreesC abolished the effect of PTH both to activate [adenylate cyclase] and to *inhibit* . Negative_regulation ADCY6 CA12 233968 1412 Calcium 5 mM also partially abolished effects of PTH to activate [adenylate cyclase] and to *inhibit* . Negative_regulation ADCY6 EDN2 1316904 185765 *inhibits* [adenylate cyclase] and stimulates phosphoinositide hydrolysis in adult cardiac myocytes . Negative_regulation ADCY6 GPR115 7684247 217201 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY6 GPR132 7684247 217190 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY6 GPR87 7684247 217270 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY6 MAOA 3234480 103056 These data suggest that chronic nonselective and chronic inhibition *causes* a down-regulation of the 5-HT1A mediated inhibition of forskolin stimulated [adenylate cyclase] activity . Negative_regulation ADCY6 MAP2K6 8071375 270376 Both mutant PAF receptors more potently activated the other signals ( , arachidonate release , and *inhibition* of [adenylate cyclase] ) than did the wild type receptor . Negative_regulation ADCY6 PTGER2 1667331 176584 In conclusion , activation of protein kinase C by phorbol esters reveals a Gi-mediated *induced* inhibition of [adenylate cyclase] in addition to the prostaglandin E receptor mediated stimulation of cAMP accumulation in Jurkat cells . Negative_regulation ADCY6 S100B 18445708 1938546 and 5 ) coexpression of in D ( 2 ) receptor expressing 293 cells selectively *increased* D ( 2 ) receptor stimulation of extracellular signal regulated kinases and inhibition of [adenylate cyclase] . Negative_regulation ADCY6 S100B 3191991 101180 *inhibits* the [adenylate cyclase] activity in the presence of Mg2+ ( 5.0-50 mM ) , while it activates the same enzyme in the presence of Ca2+ ( 0.1-1.0 mM ) dose-dependently in both cases . Negative_regulation ADCY6 SELL 1521577 196985 Addition of the octapeptide , Met5-enk *resulted* in decreased [adenylate cyclase] activity ; Negative_regulation ADCY6 SRGN 2120055 141867 Hepatocytes from obese Zucker rats displayed a resistance to both agonist induced phosphorylation of alpha Gi-2 and to p [ NH ] *mediated* inhibition of [adenylate cyclase] . Negative_regulation ADCY6 SRGN 2511846 121779 The ability of p [ NH ] to *inhibit* forskolin stimulated [adenylate cyclase] activity was attenuated in the presence of insulin . Negative_regulation ADCY7 ADRB2 9271340 450269 In previous studies , it was shown that the overexpression of in the hearts of transgenic mice ( Tg ) *leads* to agonist independent activation of [adenylate cyclase] and enhanced myocardial function . Negative_regulation ADCY7 CA12 233968 1165 The inhibitory effect of PTH was ATP- , Mg++- , and K+-dependent and temperature dependent ; inactivation of PTH by heating at 100degreesC abolished the effect of PTH both to activate [adenylate cyclase] and to *inhibit* . Negative_regulation ADCY7 CA12 233968 1425 Calcium 5 mM also partially abolished effects of PTH to activate [adenylate cyclase] and to *inhibit* . Negative_regulation ADCY7 EDN2 1316904 185768 *inhibits* [adenylate cyclase] and stimulates phosphoinositide hydrolysis in adult cardiac myocytes . Negative_regulation ADCY7 GPR115 7684247 217294 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY7 GPR132 7684247 217283 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY7 GPR87 7684247 217363 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY7 MAOA 3234480 103058 These data suggest that chronic nonselective and chronic inhibition *causes* a down-regulation of the 5-HT1A mediated inhibition of forskolin stimulated [adenylate cyclase] activity . Negative_regulation ADCY7 MAP2K6 8071375 270383 Both mutant PAF receptors more potently activated the other signals ( , arachidonate release , and *inhibition* of [adenylate cyclase] ) than did the wild type receptor . Negative_regulation ADCY7 PTGER2 1667331 176588 In conclusion , activation of protein kinase C by phorbol esters reveals a Gi-mediated *induced* inhibition of [adenylate cyclase] in addition to the prostaglandin E receptor mediated stimulation of cAMP accumulation in Jurkat cells . Negative_regulation ADCY7 S100B 18445708 1938547 and 5 ) coexpression of in D ( 2 ) receptor expressing 293 cells selectively *increased* D ( 2 ) receptor stimulation of extracellular signal regulated kinases and inhibition of [adenylate cyclase] . Negative_regulation ADCY7 S100B 3191991 101182 *inhibits* the [adenylate cyclase] activity in the presence of Mg2+ ( 5.0-50 mM ) , while it activates the same enzyme in the presence of Ca2+ ( 0.1-1.0 mM ) dose-dependently in both cases . Negative_regulation ADCY7 SELL 1521577 196988 Addition of the octapeptide , Met5-enk *resulted* in decreased [adenylate cyclase] activity ; Negative_regulation ADCY7 SRGN 2120055 141868 Hepatocytes from obese Zucker rats displayed a resistance to both agonist induced phosphorylation of alpha Gi-2 and to p [ NH ] mediated *inhibition* of [adenylate cyclase] . Negative_regulation ADCY7 SRGN 2511846 121780 The ability of p [ NH ] to *inhibit* forskolin stimulated [adenylate cyclase] activity was attenuated in the presence of insulin . Negative_regulation ADCY8 ADRB2 9271340 450270 In previous studies , it was shown that the overexpression of in the hearts of transgenic mice ( Tg ) *leads* to agonist independent activation of [adenylate cyclase] and enhanced myocardial function . Negative_regulation ADCY8 CA12 233968 1178 The inhibitory effect of PTH was ATP- , Mg++- , and K+-dependent and temperature dependent ; inactivation of PTH by heating at 100degreesC abolished the effect of PTH both to activate [adenylate cyclase] and to *inhibit* . Negative_regulation ADCY8 CA12 233968 1438 Calcium 5 mM also partially abolished effects of PTH to activate [adenylate cyclase] and to *inhibit* . Negative_regulation ADCY8 EDN2 1316904 185771 *inhibits* [adenylate cyclase] and stimulates phosphoinositide hydrolysis in adult cardiac myocytes . Negative_regulation ADCY8 GPR115 7684247 217387 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY8 GPR132 7684247 217376 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY8 GPR87 7684247 217456 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY8 MAOA 3234480 103060 These data suggest that chronic nonselective and chronic inhibition *causes* a down-regulation of the 5-HT1A mediated inhibition of forskolin stimulated [adenylate cyclase] activity . Negative_regulation ADCY8 MAP2K6 8071375 270390 Both mutant PAF receptors more potently activated the other signals ( , arachidonate release , and *inhibition* of [adenylate cyclase] ) than did the wild type receptor . Negative_regulation ADCY8 PTGER2 1667331 176592 In conclusion , activation of protein kinase C by phorbol esters reveals a Gi-mediated *induced* inhibition of [adenylate cyclase] in addition to the prostaglandin E receptor mediated stimulation of cAMP accumulation in Jurkat cells . Negative_regulation ADCY8 S100B 18445708 1938548 and 5 ) coexpression of in D ( 2 ) receptor expressing 293 cells selectively *increased* D ( 2 ) receptor stimulation of extracellular signal regulated kinases and inhibition of [adenylate cyclase] . Negative_regulation ADCY8 S100B 3191991 101184 *inhibits* the [adenylate cyclase] activity in the presence of Mg2+ ( 5.0-50 mM ) , while it activates the same enzyme in the presence of Ca2+ ( 0.1-1.0 mM ) dose-dependently in both cases . Negative_regulation ADCY8 SELL 1521577 196991 Addition of the octapeptide , Met5-enk *resulted* in decreased [adenylate cyclase] activity ; Negative_regulation ADCY8 SRGN 2120055 141869 Hepatocytes from obese Zucker rats displayed a resistance to both agonist induced phosphorylation of alpha Gi-2 and to p [ NH ] *mediated* inhibition of [adenylate cyclase] . Negative_regulation ADCY8 SRGN 2511846 121781 The ability of p [ NH ] to *inhibit* forskolin stimulated [adenylate cyclase] activity was attenuated in the presence of insulin . Negative_regulation ADCY9 ADRB2 9271340 450271 In previous studies , it was shown that the overexpression of in the hearts of transgenic mice ( Tg ) *leads* to agonist independent activation of [adenylate cyclase] and enhanced myocardial function . Negative_regulation ADCY9 CA12 233968 1191 The inhibitory effect of PTH was ATP- , Mg++- , and K+-dependent and temperature dependent ; inactivation of PTH by heating at 100degreesC abolished the effect of PTH both to activate [adenylate cyclase] and to *inhibit* . Negative_regulation ADCY9 CA12 233968 1451 Calcium 5 mM also partially abolished effects of PTH to activate [adenylate cyclase] and to *inhibit* . Negative_regulation ADCY9 EDN2 1316904 185774 *inhibits* [adenylate cyclase] and stimulates phosphoinositide hydrolysis in adult cardiac myocytes . Negative_regulation ADCY9 GPR115 7684247 217480 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY9 GPR132 7684247 217469 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY9 GPR87 7684247 217549 LPA stimulates phospholipase C and *inhibits* [adenylate cyclase] in its target cells , apparently by activating a specific . Negative_regulation ADCY9 MAOA 3234480 103062 These data suggest that chronic nonselective and chronic inhibition *causes* a down-regulation of the 5-HT1A mediated inhibition of forskolin stimulated [adenylate cyclase] activity . Negative_regulation ADCY9 MAP2K6 8071375 270397 Both mutant PAF receptors more potently activated the other signals ( , arachidonate release , and *inhibition* of [adenylate cyclase] ) than did the wild type receptor . Negative_regulation ADCY9 PTGER2 1667331 176596 In conclusion , activation of protein kinase C by phorbol esters reveals a Gi-mediated *induced* inhibition of [adenylate cyclase] in addition to the prostaglandin E receptor mediated stimulation of cAMP accumulation in Jurkat cells . Negative_regulation ADCY9 S100B 18445708 1938549 and 5 ) coexpression of in D ( 2 ) receptor expressing 293 cells selectively *increased* D ( 2 ) receptor stimulation of extracellular signal regulated kinases and inhibition of [adenylate cyclase] . Negative_regulation ADCY9 S100B 3191991 101186 *inhibits* the [adenylate cyclase] activity in the presence of Mg2+ ( 5.0-50 mM ) , while it activates the same enzyme in the presence of Ca2+ ( 0.1-1.0 mM ) dose-dependently in both cases . Negative_regulation ADCY9 SELL 1521577 196994 Addition of the octapeptide , Met5-enk *resulted* in decreased [adenylate cyclase] activity ; Negative_regulation ADCY9 SRGN 2120055 141870 Hepatocytes from obese Zucker rats displayed a resistance to both agonist induced phosphorylation of alpha Gi-2 and to p [ NH ] *mediated* inhibition of [adenylate cyclase] . Negative_regulation ADCY9 SRGN 2511846 121782 The ability of p [ NH ] to *inhibit* forskolin stimulated [adenylate cyclase] activity was attenuated in the presence of insulin . Negative_regulation ADCYAP1 EPHB2 12692897 1080610 C2-ceramide and [PACAP] *induced* opposite effects on phosphorylated forms of and JNK without affecting the total amounts of ERK and JNK , suggesting that a balance between these two MAP-kinases is critical for the cell survival/death decision . Negative_regulation ADD1 FAS 11160371 781722 Moreover , overexpression of [ADD-1/SREBP-1] by adenoviral gene transfer *induces* in chicken adipocytes , where lipogenesis is normally low . Negative_regulation ADH1A ADH1C 20617019 2286536 In patients with alcoholic liver disease , liver activity *increases* , while [ADH1] activity decreases , as alcohol intake increases . Negative_regulation ADH1B ALDH2 20958327 2365142 The DNA damage induced by ethanol could be attenuated by alcohol dehydrogenase 1B (ADH1B) or inhibitor , and the mRNA expression levels of [ADH1B] and ALDH2 were *increased* markedly by ethanol . Negative_regulation ADH1C ADH1A 19489444 2091271 Furthermore , [ADH3] was *induced* in damaged cells with increased hydrophobicity , whereas decreased its activity in severe liver diseases . Negative_regulation ADH1C ADH1A 20617019 2286537 Furthermore , [ADH3] is *induced* in damaged cells that have greater hydrophobicity , whereas activity is lower when there is severe liver disease . Negative_regulation ADIPOQ FOXO1 24595303 2929791 Silencing expression *prevented* C3G stimulated induction of [adiponectin] expression . Negative_regulation ADIPOQ FOXO1 24595303 2929794 In contrast , overexpression of *promoted* [adiponectin] expression in adipocytes . Negative_regulation ADIPOQ HSD11B2 19223847 2071996 The <11beta-HSD1> inhibitor had no effect on serum adiponectin , but *increased* liver [adiponectin receptor type 2 (Adipo-R2)] mRNA levels . Negative_regulation ADIPOQ IL1B 15149722 1248422 *suppressed* [adiponectin] mRNA levels substantially in both subcutaneous and visceral AT . Negative_regulation ADIPOQ IL1B 18303122 1896905 But in contrast to MCP-1 , [adiponectin] release was significantly *suppressed* by both exogenous TNF-alpha and as well as by PPARgamma antagonists bisphenol A diglycidyl ether and T0070907 ( P < 0.01 ) . Negative_regulation ADIPOQ JAG1 19540436 2099099 In contrast , NICD or transgene expression strongly inhibited adipocyte formation and *reduced* peroxisome proliferator activated receptor-gamma , fatty acid binding protein 4 , and [adiponectin] precursor gene expression . Negative_regulation ADIPOQ MAOA 23611731 2784107 In this study , however , we found that selective inhibitors , moclobemide and Ro41-1049 , and a selective MAO-B inhibitor , selegiline , *promoted* [adiponectin] production during adipocyte differentiation in hBM-MSCs , which suggested the anti-diabetic potential of these drugs . Negative_regulation ADIPOQ MAP2K6 23490586 2818589 In adipocytes , specific inhibition of MEK/ERK1/2 pathway decreased intracellular and secretory adiponectin levels , whereas adiponectin gene expression was increased , suggesting that inhibition may *promote* [adiponectin] protein degradation . Negative_regulation ADIPOQ TNF 12378384 997067 The mechanism of *induced* inhibition of [apM-1] gene expression is , at least in part , due to a decrease of transcriptional SP1 binding activity caused by TNF-alpha and thus provides a new mechanism of TNF-alpha dependent signalling . Negative_regulation ADIPOQ TNF 12927809 1131909 and ( 3 ) *inhibited* [adiponectin] , but paradoxically increased , aP2 expression in PPAR gamma 2-infected C/EBP alpha null cells . Negative_regulation ADIPOQ TNF 12974762 1139772 In contrast , , which is also produced by fat tissue , leads to insulin resistance and furthermore *inhibits* [adiponectin] mRNA production and secretion of the protein . Negative_regulation ADIPOQ TNF 15351728 1292613 The IKKbeta inhibitor cancelled the *mediated* down-regulation of [adiponectin] secretion and simultaneously up-regulated the phosphorylation of Akt in 3T3-L1 adipocytes . Negative_regulation ADIPOQ TNF 15897474 1408590 In subcutaneous adipocytes from lean subjects , *inhibited* [adiponectin] release by 7.4 +/- 1.2 % ( n = 9 , p < 0.05 ) but had no effect on adiponectin release from subcutaneous or omental adipocytes from obese subjects . Negative_regulation ADIPOQ TNF 17700650 1978911 Dietary intervention was associated with significant reductions in ( baseline : 2.2 ( s.d. 0.3 ) , post-intervention : 1.5 ( s.d. 0.3 ) pg/ml , P=0.01 ) and low-density lipoprotein-cholesterol ( baseline : 2.5 ( s.d. 0.2 ) , post-intervention : 2.3 ( s.d. 0.1 ) mmol/l , P=0.03 ) and *increased* [adiponectin] ( baseline : 6.5 ( s.d. 0.7 ) , post-intervention : 7.6 ( s.d. 0.6 ) microg/ml , P=0.02 ) . Negative_regulation ADIPOQ TNF 17895880 1874089 The release of [adiponectin] was *enhanced* by insulin and by inhibition of endogenous ( TNFalpha ) using etancercept . Negative_regulation ADIPOQ TNF 18303122 1896904 But in contrast to MCP-1 , [adiponectin] release was significantly *suppressed* by both exogenous and IL-1beta as well as by PPARgamma antagonists bisphenol A diglycidyl ether and T0070907 ( P < 0.01 ) . Negative_regulation ADIPOQ TNF 19013780 2035050 Although the [adiponectin] secretion was reduced in the *presence* of lipopolysaccharide plus and IFN-gamma , only gamma-oryzanol supported the activity of adiponectin secretion under NF-kappaB activated condition . Negative_regulation ADIPOQ TNF 19227810 2007372 [Adiponectin] secretion is *inhibited* by and by catecholamines , and is stimulated by PPAR gamma activation . Negative_regulation ADIPOQ TNF 19324019 2064565 IGFBP-3 , hypoxia and *inhibit* [adiponectin] transcription . Negative_regulation ADIPOQ TNF 19324019 2064566 The present study demonstrates that IGFBP-3 , the hypoxia-mimetic agent cobalt chloride , and *inhibit* rosiglitazone induced [adiponectin] transcription in mouse embryo fibroblasts that stably express PPAR-gamma2 . Negative_regulation ADIPOQ TNF 20521979 2271250 All 21 subset samples inhibited TNFalpha stimulated free fatty acid release and attenuated *inhibition* of [adiponectin] secretion . Negative_regulation ADIPOQ TNF 21143189 2425151 Both in rat and human ADSC-adipocytes , significantly induced proinflammatory cytokines [MCP-1 ( monocyte chemoattractant protein-1 ) and IL-6 ] and *suppressed* [adiponectin] expression , while pioglitazone antagonized these effects . Negative_regulation ADIPOQ TNF 21554928 2435390 Brazilian propolis derived components inhibit *mediated* downregulation of [adiponectin] expression via different mechanisms in 3T3-L1 adipocytes . Negative_regulation ADIPOQ TNF 21554928 2435391 The effect of various Brazilian propolis derived components on inhibition of *mediated* downregulation of [adiponectin] expression in 3T3-L1 adipocytes and molecular mechanism was investigated . Negative_regulation ADIPOQ TNF 21554928 2435392 Pretreatment with either artepillin C (C3) or its derivative ( C4 ) significantly inhibited *mediated* downregulation of [adiponectin] expression in 3T3-L1 adipocytes . Negative_regulation ADIPOQ TNF 21554928 2435393 These data demonstrate that 1 ) both C3 and C4 significantly inhibit the *mediated* downregulation of [adiponectin] in adipocytes , 2 ) C3 functions as a PPAR? agonist , and its inhibition of the effect of TNF-a is due to this PPAR? transactivation , and 3 ) C4 is an effective inhibitor of JNK activation , thus inhibiting the TNF-a mediated downregulation of adiponectin . Negative_regulation ADIPOQ TNF 21554928 2435394 Brazilian propolis derived components ( C3 and C4 ) can significantly inhibit *mediated* downregulation of [adiponectin] in adipocytes , although they do so via different mechanisms . Negative_regulation ADIPOQ TNF 22571939 2619223 Accumulative studies have shown that there exists a reciprocal relationship between adiponectin and TNF-a , i.e. , adiponectin negatively regulates TNF-a expression , whereas [adiponectin] expression is *inhibited* by . Negative_regulation ADIPOQ TNF 22744305 2644409 Stimulation of human adipocytes with a over 6 and 24 h *resulted* in a significant decrease in [adiponectin] mRNA transcripts . Negative_regulation ADIPOQ TNF 23381555 2860761 [Adiponectin] gene transcription and mRNA stability were both *reduced* by . Negative_regulation ADIPOQ TNF 23381555 2860762 opposes the action of adiponectin in the regulation of lipid metabolism , and *inhibits* [adiponectin] expression at transcriptional and post-transcriptional levels . Negative_regulation ADIPOR1 MAP2K6 22012952 2526912 P13K inhibitor LY294002 and Akt1/2 kinase inhibitor but not the ERK1/2 kinase ( ) inhibitors PD98059 and U0126 *blocked* the insulin induced reduction in [AdipoR1] expression and AMPK phosphorylation . Negative_regulation ADIPOR2 FOXO1 21194380 2443135 *Role* of signaling in dietary saturated fat dependent upregulation of liver [adiponectin receptor 2] in ethanol administered mice . Negative_regulation ADM CTGF 18401334 1920302 In this model , there is upregulation of mRNA expression and extracellular signal regulated kinase ( ERK ) phosphorylation , and [adrenomedullin] overexpression *suppressed* both of these activities without altering the blood pressure . Negative_regulation ADRA1B MAP2K6 19302552 2052082 It was observed that at nanomolar concentrations the inhibitors , PD98059 ( 2'-amino-3'-methoxyflavone ) and UO126 [ 1,4- ( diamino-2,3-dicyano/1,4-bis- ( 2-aminophenylthio ) -butadiene ] , *increased* [alpha(1B)-adrenoceptor] phosphorylation and diminished the functional response of this receptor to noradrenaline . Negative_regulation ADRB2 DNM1 11311137 804890 On the other hand , agonist promoted sequestration of the [beta(2)-adrenergic receptor] was dramatically *inhibited* by K44A ( 81.2+/-16.3 % ) and by arrestin- ( 319-418 ) ( 36.9+/-4.4 % ) . Negative_regulation ADRB2 DNM2 11311137 804891 On the other hand , agonist promoted sequestration of the [beta(2)-adrenergic receptor] was dramatically *inhibited* by K44A ( 81.2+/-16.3 % ) and by arrestin- ( 319-418 ) ( 36.9+/-4.4 % ) . Negative_regulation ADRB2 DNM3 11311137 804889 On the other hand , agonist promoted sequestration of the [beta(2)-adrenergic receptor] was dramatically *inhibited* by K44A ( 81.2+/-16.3 % ) and by arrestin- ( 319-418 ) ( 36.9+/-4.4 % ) . Negative_regulation ADRB2 GIT1 9826657 550629 Overexpression of *leads* to reduced [beta2-adrenergic receptor] signaling and increased receptor phosphorylation , which result from reduced receptor internalization and resensitization . Negative_regulation ADRB2 GPR88 23936473 2826954 In marked contrast , in non ciliated cells , was distributed throughout the plasma membrane and *inhibited* the [B2AR] response . Negative_regulation ADRB2 GRK1 11858796 914614 These data suggest that the increase in activity may be one of the mechanisms underlying alterations in the coupling between beta2-adrenoceptor and adenylyl cyclase via G-protein and may thus *contribute* to the downregulation of [beta2-adrenoceptor] in cystic fibrosis lung . Negative_regulation ADRB2 GRK4 11858796 914616 These data suggest that the increase in activity may be one of the mechanisms underlying alterations in the coupling between beta2-adrenoceptor and adenylyl cyclase via G-protein and may thus *contribute* to the downregulation of [beta2-adrenoceptor] in cystic fibrosis lung . Negative_regulation ADRB2 GRK5 11858796 914617 These data suggest that the increase in activity may be one of the mechanisms underlying alterations in the coupling between beta2-adrenoceptor and adenylyl cyclase via G-protein and may thus *contribute* to the downregulation of [beta2-adrenoceptor] in cystic fibrosis lung . Negative_regulation ADRB2 GRK6 11858796 914618 These data suggest that the increase in activity may be one of the mechanisms underlying alterations in the coupling between beta2-adrenoceptor and adenylyl cyclase via G-protein and may thus *contribute* to the downregulation of [beta2-adrenoceptor] in cystic fibrosis lung . Negative_regulation ADRB2 GRK7 11858796 914615 These data suggest that the increase in activity may be one of the mechanisms underlying alterations in the coupling between beta2-adrenoceptor and adenylyl cyclase via G-protein and may thus *contribute* to the downregulation of [beta2-adrenoceptor] in cystic fibrosis lung . Negative_regulation ADRB2 NOS1 11324456 765129 The organ-bath was used to observe the tension changes in rings of coronary and femoral arteries to different concentrations of isoprenaline ( ISO ) after endothelium removal , *inhibition* by L-NMMA and beta 1 and/or [beta 2 adrenoceptor] antagonization . Negative_regulation ADRB2 OXTR 9584840 504447 [Beta2-adrenoceptor] desensitization in non-pregnant estrogen primed rat myometrium *involves* modulation of gene expression . Negative_regulation ADRB2 RHO 24605225 2925139 Our previous study showed that guanine nucleotide dissociation inhibitor 2 ( RhoGDI2 ) overexpression *induced* [beta-2 adrenergic receptor] ( ß2AR ) desensitization in airway smooth muscle cells . Negative_regulation ADRB2 SRC 14990578 1243145 Here we used mouse embryonic fibroblast (MEF) cells deficient in Src family tyrosine kinases to examine the *role* of in [beta2-adrenergic receptor] signaling to the MAPK pathway and in receptor internalization . Negative_regulation ADRB2 TGFB1 11138844 760358 *inhibits* [beta2-adrenoceptor] gene transcription . Negative_regulation ADRB2 TGFB1 11138844 760360 In summary , *induces* [beta2-adrenoceptor] desensitization through the alteration in adenylyl cyclase activity and down-regulation of beta2-adrenoceptor mRNA and protein through the reduction in the rate of beta2-adrenoceptor gene transcription . Negative_regulation ADRB2 TNF 8387402 217981 *causes* homologous desensitization of lymphocyte [beta 2-adrenergic receptor] response . Negative_regulation ADRB3 TNF 10884431 709573 The absence of both receptors or p55 receptor alone *resulted* in a significant reduction in brown adipocyte apoptosis and an increase in [beta(3)-adrenoreceptor] and uncoupling protein-1 expression in obese mice . Negative_regulation ADRBK1 EPHB2 10574913 569202 Inhibition of ERK activity in HEK293 cells potentiates GRK2 activity , whereas , conversely , activation *inhibits* [GRK2] activity . Negative_regulation ADRBK1 IL1B 17869478 1843176 signaling is *required* for mechanical allodynia induced by nerve injury and for the ensuing reduction in spinal cord neuronal [GRK2] . Negative_regulation ADRBK1 IL1B 17869478 1843177 We hypothesized that in the L5 SNT model mechanical allodynia would be associated with reduced neuronal GRK2 levels in the spinal cord dorsal horn and that signaling would be *required* to induce both the decrease in [GRK2] and mechanical allodynia . Negative_regulation ADRBK1 IL1B 17869478 1843178 These results suggest a functional relation between the L5 SNT induced *mediated* decrease in [GRK2] and development of mechanical allodynia . Negative_regulation ADRBK1 TNF 16385076 1533414 Moreover , inhibitors of the SMases and an inhibitor of c-Jun NH2-terminal kinase , also a downstream effector in the SMase pathway , reversed *mediated* effects on [GRK2] translocation and A2A R desensitization . Negative_regulation AFP HBEGF 10213920 608096 selectively *suppressed* the [AFP] enhancer activity , resulting in decreased levels of both albumin and AFP mRNA in HuH-7 cells . Negative_regulation AFP HBEGF 10213920 608099 In contrast , HB-EGF did not influence the albumin transcripts in huH-1/cl.2 cells or primary culture of rat hepatocytes , although the [AFP] enhancer activity was *reduced* by in huH-1/cl.2 cells as well as in HuH-7 cells . Negative_regulation AGR2 CDKN1A 24190633 2885898 MHY218 also caused an increase in the expression levels of ( WAF1/CIP1 ) , [a G2/M] phase *inhibitor* , in a p53 independent pathway . Negative_regulation AGR2 EDC3 16389457 1512752 When added to cultures of transformed cells , *induced* [a G2/M] blockade followed by cell death . Negative_regulation AGR2 EDC4 16389457 1512751 When added to cultures of transformed cells , *induced* [a G2/M] blockade followed by cell death . Negative_regulation AGR2 LATS1 11850843 913151 Ectopic expression of in MCF-7 cells specifically down-regulates Cyclin A and Cyclin B protein levels and dramatically reduces CDC2 kinase activity , *leading* to [a G2/M] blockade . Negative_regulation AGR2 PTPRC 1431097 202778 Based on this observation , experiments were designed to examine the *role* of in regulation of [AgR] complex phosphorylation . Negative_regulation AGR2 SETD2 23712868 2870495 Expression of the oxygen dependent degradation domain mutant in cells *resulted* in elevated [AGR2] levels and an increased ability to induce HUVEC migration and tube formation in vitro and enhanced growth and vascularity of tumor xenografts in vivo , which were prevented by AGR2 knockdown . Negative_regulation AGR2 SH3D19 20048076 2193010 We show that the anti-invasive effect of occurs , at least in part , through its ability to *inhibit* [AGR2] expression . Negative_regulation AGRP IL1B 18583425 1966056 Furthermore , we demonstrate that *inhibits* the release of [AgRP] from hypothalamic explants . Negative_regulation AGT TNF 20592241 2320433 *reduced* [AGT] protein accumulation in the medium between 8 and 24 h ( 0.62 ± 0.13 by 40 ng/ml TNF-a , ratio to control ) . Negative_regulation AGTR2 TNF 19399939 2070318 After treatment with 5-FU , , IL-1 , and IL-6 in serum of rats of Group C were *inhibited* [at 2] and 6 h after operation ( P < 0.05 ) , and IL-10 , TGF-beta were inhibited at 24 h compared to Group B ( P < 0.05 ) . Negative_regulation AGXT TNF 17715340 1783381 Such a reduction in astrocyte expressed [AGT] and AngII is *dependent* , in vitro , on the proinflammatory cytokines and interferon-gamma . Negative_regulation AGXT TNF 20592241 2320432 *suppressed* [AGT] mRNA expression in a dose- and time dependent manner . Negative_regulation AHCTF1 TNF 22025632 2508071 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation AHR EPHB2 15572374 1368338 kinase inhibition *stabilizes* the [aryl hydrocarbon receptor] : implications for transcriptional activation and protein degradation . Negative_regulation AHR IL1B 18483242 1910711 Silencing of RELA expression alleviated *mediated* repression of [AHR] transcriptional activity , whereas PMA mediated repression was maintained . Negative_regulation AHR SELL 18382861 1892987 When CD4+ and CD8+ donor T-cells from AhR-WT and AhR-KO mice were injected in various combinations into F1 mice , the enhanced expression of CD25 on CD8+ T-cells required AhR in donor CD4+ T-cells , while down-regulation of *required* [AhR] in the donor CD8+ T-cells themselves . Negative_regulation AHR TNF 16159621 1455993 blockade *resulted* in significant inhibition of the late [AHR] without affecting the early AHR , and reduction in airway eosinophilia and inflammation . Negative_regulation AHR TNF 17336618 1707640 However , studies with TNF-deficient or TNF receptor-deficient mice have not produced a clear picture of the *role* of in the [AHR] associated with allergic inflammation in the mouse . Negative_regulation AHR TNF 17372990 1720544 We have investigated the *role* of in mast cell mediated late [airway hyperresponsiveness (AHR)] using mast cell-deficient WBB6F1-W/W ( v ) ( W/W ( v ) ) mice in a murine model of asthma , which exhibits a biphasic increase in AHR . Negative_regulation AHRR IL1B 1554389 184281 A time course experiment indicated that *inhibited* hepatocyte [AHH] activity after only 2 hr of incubation . Negative_regulation AHSA1 EPHB2 18619440 1941780 Serum starvation *induced* [p38] phosphorylation , whereas it did not affect the phosphorylation of or JNK . Negative_regulation AHSA1 EPHB2 9553146 499562 The *activation* of [p38] and apoptosis by the inhibition of is antagonized by the phosphoinositide 3-kinase/Akt pathway . Negative_regulation AHSA1 MAP2K6 20503247 2289205 Expression of dominant negative forms of A-Raf , MKK4 or and pharmacological *inhibition* of MEK and [p38] revealed that extracellular signal regulated protein kinase , p38 and c-Jun NH ( 2 ) -terminal protein kinase participate in the upregulation of AP-1 activity . Negative_regulation AHSG IL1B 2848721 100502 Monocyte conditioned medium , recombinant human interleukin-6 ( rhIL6 ) and ( rhIL1 beta ) all *down-regulated* the synthesis of [AHSG] . Negative_regulation AIS1 NFASC 22492029 2583480 Loss of in both Purkinje and basket neurons *caused* abnormal basket axon collateral branching and targeting to Purkinje [soma/AIS] , leading to extensive pinceau disorganization , Purkinje neuron degeneration , and severe ataxia . Negative_regulation AIS2 NFASC 22492029 2583481 Loss of in both Purkinje and basket neurons *caused* abnormal basket axon collateral branching and targeting to Purkinje [soma/AIS] , leading to extensive pinceau disorganization , Purkinje neuron degeneration , and severe ataxia . Negative_regulation AIS3 NFASC 22492029 2583482 Loss of in both Purkinje and basket neurons *caused* abnormal basket axon collateral branching and targeting to Purkinje [soma/AIS] , leading to extensive pinceau disorganization , Purkinje neuron degeneration , and severe ataxia . Negative_regulation AKT1 ABCA12 24950409 2947211 In the cell-free assay significantly *inhibited* phosphoinositide 3-kinase (PI3K) mediated phosphorylation of [Akt1] at Ser473 , but Li2CO3 did not affect PI3K mediated PI ( 3,4,5 ) P3 production and 3-phosphoinositide dependent protein kinase 1 ( PDK1 ) -mediated phosphorylation of Akt1 at Thr308 . Negative_regulation AKT1 ARSA 23867870 2830025 Therefore , <5-ASA> reduces CUC induced reactive oxygen species in colonic progenitor cells and enhances PTEN activity , thus *attenuating* [PI3K/Akt] signaling . Negative_regulation AKT1 CAPN8 20347887 2266287 Interestingly , inhibitors of proteosome , or caspase mediated proteolysis did not significantly *block* [AKT] loss . Negative_regulation AKT1 CCND1 20529342 2277414 The molecular analysis of tumor samples and in vitro experiments indicated that MTA induces cytostatic rather than pro-apoptotic effects inhibiting the phosphorylation of [Akt] and S6 ribosomal protein and *inducing* the down-regulation of . Negative_regulation AKT1 CCND1 23237355 2711142 Essential oil activated the caspase dependent apoptotic pathway , *induced* a rapid and transient activation of [Akt] and Erk1/2 , and suppressed levels of expression in cultured pancreatic cancer cells . Negative_regulation AKT1 CCND1 24596136 2955913 Baicalein induced G0/G1-phase arrest in hepatocellular carcinoma cells , *inhibited* [AKT] , and promoted the degradation of ß-catenin and without activation of GSK-3ß . Negative_regulation AKT1 EPHB2 10629859 576449 Expression of GRK2-ct inhibited the H2O2 induced activation of by 70 % and also *inhibited* the activation of [Akt] by 30 % . Negative_regulation AKT1 EPHB2 11228049 763988 PD98059 inhibited activation of and LY294002 *repressed* activation of [Akt] in response to IGF-I , but did not affect tyrosine phosphorylation of the IGF-IR , IRS-1 , IRS-2 , or Shc . Negative_regulation AKT1 EPHB2 11445578 850509 Finally , examination of the phosphorylation state of Akt after HGF stimulation revealed that inhibition *resulted* in a decrease in [Akt] activation at both 5 and 10 min . Negative_regulation AKT1 EPHB2 12514175 1063814 Together , our data suggest that GDF-15 prevents apoptosis in CGN by activating [Akt] and *inhibiting* endogenously active . Negative_regulation AKT1 EPHB2 14978732 1213596 ( 2 ) the use of E-cadherin blocking antibodies efficiently prevents [Akt] phosphorylation and *inhibition* after 70 min of calcium restoration ; Negative_regulation AKT1 EPHB2 15351743 1292639 Expression of Gab1 PI3K-m in SK-N-MC human primitive neuroectodermal tumor cells expressing wild-type RET markedly impaired [Akt] phosphorylation , Rac1 activation , and lamellipodia formation that were *induced* by GDNF whereas expression of Gab1 SHP2-m partially impaired activation . Negative_regulation AKT1 EPHB2 15608143 1369083 MIP-2 activated extracellular signal regulated kinase ( ) 1/2 and [Akt] and both the mitogen activated protein kinase kinase 1 ( MEK1 ) and phosphatidylinositol 3-kinase (PI3K) *inhibitors* 2'-amino-3'-methoxyflavone ( PD98059 ) and wortmannin reduced the neuroprotective effect of MIP-2 . Negative_regulation AKT1 EPHB2 17418380 1748725 inhibition also significantly *increased* [Akt] phosphorylation under all conditions and decreased Smad-3 phosphorylation in the presence of IL-13+TGF-beta1 . Negative_regulation AKT1 EPHB2 18538131 1928838 OML induced phosphorylation was inhibited by specific inhibitors of PI3K and SFKs , and OML induced [Akt] phosphorylation was *inhibited* by a inhibitor of SFKs . Negative_regulation AKT1 EPHB2 19201774 2149168 All COX inhibitors attenuated activation , but only celecoxib significantly *inhibited* [Akt] activation in HSCs . Negative_regulation AKT1 EPHB2 19762915 2158780 In normal human chondrocytes , tBHP triggered strong IRS-1 ( Ser-312 and Ser-616 ) and phosphorylation and *inhibited* IGF-I induced IRS-1 ( Tyr-612 ) and [Akt] phosphorylation . Negative_regulation AKT1 EPHB2 19762915 2158844 Chemical inhibition of significantly *enhanced* IGF-I phosphorylation of [Akt] and alleviated tBHP inhibition of Akt phosphorylation . Negative_regulation AKT1 EPHB2 20512842 2270607 We found that low concentrations rapamycin increased Akt and phosphorylation through a mTORC1 dependent mechanism because knockdowned raptor induced the activation of Akt and ERK , but higher doses of rapamycin *inhibited* [Akt] and ERK phosphorylation mainly via the mTORC2 signaling pathway because that the silencing of rictor led to the inhibition of Akt and ERK phosphorylation . Negative_regulation AKT1 EPHB2 20714148 2312969 Sorafenib reduced c-Kit , and VEGFR2 activation and on the other hand , gemcitabine *inhibited* [Akt] phosphorylation . Negative_regulation AKT1 EPHB2 21148681 2390253 Inhibition of JNK , but not p38 MAPK and , *reduced* [Akt] phosphorylation . Negative_regulation AKT1 EPHB2 21529991 2489597 Sorafenib reduced c-Kit and activation and gemcitabine *inhibited* [Akt] phosphorylation . Negative_regulation AKT1 EPHB2 21945981 2507232 Exposure of SW480 cells to ECG led to apoptosis as determined by caspase-3 activity , imbalance among Bcl-2 anti- and pro-apoptotic protein levels , activation and [AKT] *inhibition* , whereas PB2 treatment enhanced phospho-AKT and phospho-ERK levels . Negative_regulation AKT1 EPHB2 22129743 2515086 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 mitogen activated protein kinase (MAPK) and [Akt] phosphorylation , but in contrast , *inhibited* that of ( 1/2 ) . Negative_regulation AKT1 EPHB2 22509025 2589536 By suppressing GRK expression with siRNA , we demonstrated that lowering GRK5/6 abolishes IGF1 mediated ERK and AKT activation , whereas GRK2 inhibition increases activation and partially *inhibits* [AKT] signaling . Negative_regulation AKT1 FAS 15806173 1417486 In contrast , inhibition of activity by the drug C75 *resulted* in downregulation of [phospho-AKT] and increased cell death . Negative_regulation AKT1 FAS 15806173 1417492 Treatment with LY294002 abolished [AKT] activity and potentiated apoptosis *induced* by inhibitors cerulenin or C75 only in cells with constitutively active AKT , suggesting that constitutive activation of AKT protects against FAS inhibitor induced cell death . Negative_regulation AKT1 FAS 15806173 1417495 Furthermore , inhibition of activity by cerulenin or C75 *resulted* in downregulation of [phospho-AKT] , which preceded the induction of apoptosis . Negative_regulation AKT1 FAS 25086185 2956910 Surprisingly , in *response* to suppression , we observed robust increases in both [Akt] and ERK phosphorylation . Negative_regulation AKT1 FBXO32 24002653 2856146 To accomplish this goal , in vivo transfection of plasmid DNA was used to create transient transgenic mouse skeletal muscles , and our results show for the first time that Smad3 expression is sufficient to stimulate promoter activity , *inhibit* [Akt/mTOR] signaling and protein synthesis , and induce muscle fiber atrophy . Negative_regulation AKT1 FOXO1 10960473 751690 Coexpression of the Forkhead transcription factor stimulates the glucose-6-phosphatase promoter activity via interaction with an insulin response unit (IRU) , and this activation is *suppressed* by [protein kinase B] . Negative_regulation AKT1 FOXO1 16076959 1442282 Furthermore , in in vitro kinase reactions , the association of wild-type and its target DNA sequence *inhibits* the [protein kinase B-dependent] phosphorylation of Foxo1 , whereas mutated Foxo1 proteins , which mimic constitutively acetylated states , are efficiently phosphorylated even in the presence of the DNA . Negative_regulation AKT1 FOXO1 17210752 1681612 Interestingly , overexpression of constitutively active also *led* to activation of MEK and [Akt] phosphorylation . Negative_regulation AKT1 FOXO1 18077353 1836756 In addition , activity suppresses protein phosphatase 2A (PP2A) and *disrupts* [Akt-PP2A] and Akt-calcineurin interactions . Negative_regulation AKT1 FOXO1 21940942 2507176 Deacetylated *inhibits* free cholesterol induced [Akt] phosphorylation and increases levels of the nuclear factor-?B precursor p105 , decreasing nuclear translocation of nuclear factor-?B p65 subunit and dampening mitogen activated protein/extracellular signal regulated kinase activation to prevent inflammation . Negative_regulation AKT1 FOXO1 22515357 2584469 Infection with oipA mutants reduced PI3K/Akt activation and inhibited FoxO1/3a phosphorylation , whereas infection with cag PAI mutants reduced [PI3K/Akt] activity but did not *inhibit* activation . Negative_regulation AKT1 FOXO1 24453252 2913008 Our findings not only identify Mst kinases as the long-searched-for factors that simultaneously activate and *inhibit* TCR stimulated [Akt] downstream of TCR signaling to promote Foxp3 expression and Treg development , but also shed new light on understanding and designing better therapeutic strategies for MST1 deficiency mediated human immunodeficiency syndrome . Negative_regulation AKT1 FUT4 20506505 2307904 Results show that overexpression of *increases* the phosphorylation of ERK1/2 , p38 MAPK , and [PI3K/Akt] . Negative_regulation AKT1 HSD11B2 19675138 2150730 Selective <11beta-HSD1> inhibition decreases pSer ( 307 ) IRS1 , *increases* pThr ( 308 ) [Akt/PKB] , and decreases lipogenic and lipolytic gene expression that may represent an important mechanism underpinning their insulin sensitizing action . Negative_regulation AKT1 IFI27 16489017 1524897 Expression of in MCF7 breast cancer cells *down-regulated* RhoA and increased motility , survival , and [Akt] levels without an effect on cell cycle distribution . Negative_regulation AKT1 IFI27 19158484 2027269 Inhibition of ( Kip1 ) gene expression by PDGF *required* protein synthesis and histone deacetylase activity but not [Akt] or ERK activity . Negative_regulation AKT1 IFI27 20823108 2336467 Western blot analysis revealed that honokiol : ( i ) inhibited the levels of cyclins D1 , D2 and E and associated cyclin dependent kinases (CDKs)2 , CDK4 and CDK6 , ( ii ) upregulated Cip/p21 and and ( iii ) *inhibited* the levels of phosphatidylinositol 3-kinase and the phosphorylation of [Akt] at Ser ( 473 ) in UVB induced skin tumors . Negative_regulation AKT1 IL1B 11976320 953989 CaMKKc and [Akt] overexpression decreases IRAK1 mediated NF-kappaB activity and its association with MyD88 in *response* to stimulation . Negative_regulation AKT1 IL1B 16718462 1584815 A synthetic peptide , C3d , reported to bind NCAM , did not activate MAPK or [Akt] as reported in neurons but *inhibited* induced MAPK activity , thereby mimicking the effect of SU5402 . Negative_regulation AKT1 IL1B 17467122 1931670 In trophic support deprived neurons , compromised the PI3-K/Akt pathway mediated protection by BDNF and *suppressed* [Akt] activation . Negative_regulation AKT1 IL1B 20632386 2316665 Our results showed that GDNF resulted in a significant reduction in enhanced permeability , *inhibited* MPO activity , and TNF-alpha expression , and increased ZO-1 and [Akt] expression . Negative_regulation AKT1 IL1R2 22940184 2701657 A further study indicated that alantolactone attenuated the phosphorylation of [Akt] and *inhibited* the expression of MyD88 and domain containing adaptor protein ( TIRAP ) , an upstream signaling molecule required for IKK and MAPKs activation . Negative_regulation AKT1 INPP4B 24070612 2857803 Further , we show that but not PTEN is able to reduce tyrosine phosphorylation of Akt1 and both the lipid and PTP activity of INPP4B likely *contribute* to the reduction of [Akt1] phosphorylation . Negative_regulation AKT1 IRS4 19029952 2029396 Once expressed , as well as binding to E1A and the insulin receptor , remains tyrosine phosphorylated and constitutively associates with the regulatory p85 subunit of phosphoinositide 3 kinase , *resulting* in the phosphorylation of [Akt] ( causing activation ) and GSK-3beta ( causing inhibition ) . Negative_regulation AKT1 KLF9 24737412 2936309 Intriguingly , expression severely *suppressed* the activation of [AKT] and its downstream targets . Negative_regulation AKT1 KLF9 24737412 2936312 These data collectively showing that substantially *inhibits* [AKT] activation and abrogates tumor growth of PCa cells , suggest the potential of either genetic or pharmacological activation of KLF9 in the therapeutic treatment of castration-resistant PCa . Negative_regulation AKT1 MAP2K6 14978732 1213602 ( 2 ) the use of E-cadherin blocking antibodies efficiently prevents [Akt] phosphorylation and *inhibition* after 70 min of calcium restoration ; Negative_regulation AKT1 MAP2K6 15177934 1255143 The effects of NT on [EGFR/ERK/Akt] activation and DNA synthesis were *attenuated* by PLC-inhibitor ( U73122 ) , PKC-inhibitors ( bisindolylmaleimide , staurosporine , rottlerin ) , inhibitor ( U0126 ) and PI3 kinase inhibitors ( wortmannin , LY 294002 ) . Negative_regulation AKT1 MAP2K6 15361836 1303939 or PI3K inhibitors *suppressed* ERK or [Akt] activation , respectively , and induced apoptosis in the v-ErbB : ER-responsive cells . Negative_regulation AKT1 MAP2K6 17418380 1748731 inhibition also significantly *increased* [Akt] phosphorylation under all conditions and decreased Smad-3 phosphorylation in the presence of IL-13+TGF-beta1 . Negative_regulation AKT1 MAP2K6 22552284 2618758 inhibition *leads* to [PI3K/AKT] activation by relieving a negative feedback on ERBB receptors . Negative_regulation AKT1 MAP2K6 22552284 2618793 In this study , we describe a feedback mechanism in which inhibition *leads* to activation of [PI3K/AKT] signaling in EGFR and HER2-driven cancers . Negative_regulation AKT1 MAP2K6 22561840 2608743 We found that the [phospho-Akt] level under the Raf mutation was remarkably *augmented* by inhibitor , while the phospho-ERK level was almost completely repressed . Negative_regulation AKT1 PECAM1 15985432 1441175 Tie2 and expression decreased > 80 % after siRNA treatment , and flow stimulated phosphorylation of ERK1/2 , [Akt] , and endothelial nitric oxide synthase was significantly *inhibited* by Tie2 and PECAM1 siRNA . Negative_regulation AKT1 PECAM1 16118242 1454340 *Role* of in the shear-stress induced activation of [Akt] and the endothelial nitric oxide synthase (eNOS) in endothelial cells . Negative_regulation AKT1 PLAU 23615713 2804727 In addition , avß6 integrin *induced* the phosphorylation of p38 MAPK and PI3 [K/Akt] , contributing to the up-regulation of uPA , as treatment with the specific inhibitor for p38 mitogen activated protein kinases (MAPK) ( SB203580 ) or phosphatidylinositol 3-kinase (PI3 K)/Akt ( LY294002 ) strikingly abrogated expression . Negative_regulation AKT1 RGS16 19509421 2115975 overexpression in MCF7 breast cancer cells *inhibited* EGF induced proliferation and [Akt] phosphorylation , whereas shRNA mediated extinction of RGS16 augmented cell growth and resistance to TKI treatment . Negative_regulation AKT1 RGS2 15536149 1367477 also *inhibited* Flt3-ITD induced phosphorylation of [Akt] and glycogen synthase kinase beta ( Gsk3-beta ) without influencing signal transducer and activator of transcription 5 ( STAT5 ) activation . Negative_regulation AKT1 RGS2 20362664 2261064 overexpression also significantly *attenuated* ISO induced extracellular signal regulated kinases 1 and 2 ( ERK1/2 ) and [Akt] activation , which may account for , or contribute to , its observed antihypertrophic effects . Negative_regulation AKT1 S100B 21130124 2413990 Moreover , *reduces* myoblast apoptosis in an MEK-ERK1/2 , [Akt] , JNK , and NF-?B dependent manner . Negative_regulation AKT1 SPHK1 15993704 1429706 Inhibition of SPHK-1 also did not affect EGF stimulated phosphorylation of PI-3 kinase , [Akt] , ERK1/2 or p38 but inhibition of PI-3 kinase with a specific inhibitor LY294002 partly ( 40 % ) *inhibited* the EGF stimulated increase in activity . Negative_regulation AKT1 TCN1 19422047 2096124 Here , we demonstrate that *inhibits* Akt phosphorylation at Thr308 and Ser473 and [Akt] activity in the human prostate cancer cell line PC-3 . Negative_regulation AKT1 TCN1 20489726 2327382 The Akt activation inhibitor *inhibits* [Akt] phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane . Negative_regulation AKT1 TCN1 20489726 2327388 Triciribine (TCN) phosphate ( TCN-P ) , the active metabolite of the Akt phosphorylation inhibitor TCN , is in clinical trials , but the mechanism by which *inhibits* [Akt] phosphorylation is unknown . Negative_regulation AKT1 TCN1 20489726 2327394 Here we show that in vitro , *inhibits* neither [Akt] activity nor the phosphorylation of Akt S473 and T308 by mammalian target of rapamycin or phosphoinositide dependent kinase 1 . Negative_regulation AKT1 TCN1 20489726 2327400 However , in intact cells , *inhibits* EGF stimulated [Akt] recruitment to the plasma membrane and phosphorylation of Akt . Negative_regulation AKT1 TCN1 23993427 2862081 In this phase I/II study of , a small-molecule [Akt] *inhibitor* , TCN-PM therapy was well tolerated in patients with advanced hematological malignancies , and reduced levels of phosphorylation of Akt and its substrate Bad were shown , consistent with inhibition of this survival pathway and induction of cell death . Negative_regulation AKT1 TFPI2 24591127 2886375 Furthermore , silencing of *caused* increased [Akt] phosphorylation level and NF-?B transcription in MHCC97-L cells . Negative_regulation AKT1 TLR7 24251781 2903674 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , [PI3K/AkT] *inhibition* , IKK/JNK inhibition , mTORC1 inhibition , JAK/STAT inhibition , suppression , and ACE inhibition . Negative_regulation AKT1 TNF 11067939 747589 In the presence of TNF-alpha , [Akt] activity was enhanced , and CPPD crystal induced activation of ERK1 and ERK2 was more sustained than with CPPD crystals alone , but itself *reduced* the basal phosphotransferase activities of these MAP kinases . Negative_regulation AKT1 TNF 11563846 863018 Insulin induced phosphorylation of [Akt] downstream of PI3K was *inhibited* by in a similar pattern . Negative_regulation AKT1 TNF 12089369 959669 p38 MAPK inhibition with 10 microM SB202190 that also decreased ANCA induced superoxide generation prevented S473 phosphorylation of [Akt] in *response* to and to ANCA . Negative_regulation AKT1 TNF 15646653 1349878 Stimulation of human neutrophils with granulocyte colony stimulating factor ( G-CSF ) , granulocyte-macrophage CSF (GM-CSF) , or *resulted* in phosphorylation of [Akt] , the potency being GM-CSF > G-CSF = TNF , which was inhibited by wortmannin . Negative_regulation AKT1 TNF 16712794 1564772 On the other hand , addition of or IL-6 neutralizing antibodies to the supernatant of co-culture *recovered* both IRS-2 phosphorylation and [Akt] activation . Negative_regulation AKT1 TNF 17264149 1696906 Disrupting signaling by TNF-alpha neutralizing antibody or knocking out TNF-alpha receptors *blocked* stretch activation of p38 , but not ERK1/2 , JNK or [AKT] . Negative_regulation AKT1 TNF 17449583 1730013 At the molecular level , quercetin inhibited [Akt] phosphorylation but did not *inhibit* TNF induced RelA/I-kappaB phosphorylation and IkappaB degradation or induced nuclear factor-kappaB transcriptional activity . Negative_regulation AKT1 TNF 19118509 2004810 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and and *inhibited* the phosphorylation of [Akt] , PKCdelta and p38 mitogen activated protein kinase (MAPK) . Negative_regulation AKT1 TNF 19782747 2183814 We found that a reduction in PKCdelta protein levels reversed the *mediated* reduction in insulin stimulated IRS-1 Tyr phosphorylation , [Akt] activation , and glycogen synthesis . Negative_regulation AKT1 TNF 19801900 2148203 Vaspin did not inhibit the ( 20 min ) activation of JNK , p38 and NF-kappaB , but only slightly *inhibited* [Akt] . Negative_regulation AKT1 TNF 20048146 2211532 Staurosporine , , or a Fas ligand *inhibited* both RVI and hypertonicity induced [Akt] activation in a manner sensitive to a scavenger for reactive oxygen species ( ROS ) . Negative_regulation AKT1 TNF 20164250 2227810 IL-6 and , but not IL-1beta , *inhibited* [Akt] phosphorylation within 15 min of insulin stimulation , but only IL-6 was inhibitory 30 min after stimulation . Negative_regulation AKT1 TNF 20208423 2265452 The *induced* suppression of the tyrosine phosphorylation of the insulin receptor substrate-1 (IRS-1) and [Akt] in 3T3-L1 adipocytes was also reversed by SAM . Negative_regulation AKT1 TNF 20632386 2316664 Our results showed that GDNF resulted in a significant reduction in enhanced permeability , *inhibited* MPO activity , IL-1beta and expression , and increased ZO-1 and [Akt] expression . Negative_regulation AKT1 TNF 21282635 2393018 Both FFAs and *induce* an [Akt] inhibitor , carboxyl-terminal modulator protein ( CTMP ) . Negative_regulation AKT1 TNF 22223859 2559158 Further studies showed that decreased expression of the antiapoptotic proteins Bcl-2 and Bcl-xL , decreased I?Ba and PPAR? , and also *inhibited* PI3K dependent [Akt] and EGFR signaling . Negative_regulation AKT1 TNF 22266196 2559753 DAG also reversed or attenuated the *induced* reduction in phosphorylation of [Akt] , FOXO1 , 4E-BP-1 , and GSK-3ß in myotubes . Negative_regulation AKT1 TNFSF10 11992615 938778 In addition , combined and wortmannin treatment *resulted* in cleavage of several proteins : PARP , [Akt] , p21/WAF1 , and MDM2 as well as dephosphorylation of Akt . Negative_regulation AKT1 TNFSF10 18457369 1909358 Clematis mandshurica prevents *induced* down-regulation of 14-3-3 and phosphorylated [Akt] . Negative_regulation AKT1 TNFSF10 20113484 2213103 The combination of GGTI-298 and TRAIL was more effective than each single agent in decreasing the levels of IkappaBalpha and p-Akt , implying that activates NF-kappaB and *inhibits* [Akt] . Negative_regulation AKT1 TNFSF10 22321426 2520715 To study the effects of combinative therapy of tumor necrosis factor related apoptosis inducing ligand ( ) and [PI3-K-Akt] *inhibitor* on the growth and apoptosis of nasopharyngeal carcinoma (NPC) cells and underlying mechanisms . Negative_regulation AKT1 TNFSF10 22998497 2720109 Interestingly , while *induces* a significant reduction in the levels of [phospho-Akt] ( pAkt ) and phospho-MADD ( pMADD ) in TRAIL-sensitive cells , it fails to do so in TRAIL-resistant cells . Negative_regulation AKT1 TNFSF10 24556678 2919244 Furthermore , thioridazine increased the production of reactive oxygen species ( ROS ) in Caki cells , and ROS scavengers ( N-acetylcysteine , glutathione ethyl ester , and trolox ) inhibited thioridazine plus induced apoptosis , as well as [Akt] *inhibition* and the downregulation of c-FLIP ( L ) and Mcl-1 . Negative_regulation AKT2 ARSA 23867870 2830026 Therefore , <5-ASA> reduces CUC induced reactive oxygen species in colonic progenitor cells and enhances PTEN activity , thus *attenuating* [PI3K/Akt] signaling . Negative_regulation AKT2 CAPN8 20347887 2266301 Interestingly , inhibitors of proteosome , or caspase mediated proteolysis did not significantly *block* [AKT] loss . Negative_regulation AKT2 CCND1 20529342 2277415 The molecular analysis of tumor samples and in vitro experiments indicated that MTA induces cytostatic rather than pro-apoptotic effects inhibiting the phosphorylation of [Akt] and S6 ribosomal protein and *inducing* the down-regulation of . Negative_regulation AKT2 CCND1 23237355 2711144 Essential oil activated the caspase dependent apoptotic pathway , *induced* a rapid and transient activation of [Akt] and Erk1/2 , and suppressed levels of expression in cultured pancreatic cancer cells . Negative_regulation AKT2 CCND1 24596136 2955914 Baicalein induced G0/G1-phase arrest in hepatocellular carcinoma cells , *inhibited* [AKT] , and promoted the degradation of ß-catenin and without activation of GSK-3ß . Negative_regulation AKT2 EPHB2 10629859 576451 Expression of GRK2-ct inhibited the H2O2 induced activation of by 70 % and also *inhibited* the activation of [Akt] by 30 % . Negative_regulation AKT2 EPHB2 11228049 763989 PD98059 inhibited activation of and LY294002 *repressed* activation of [Akt] in response to IGF-I , but did not affect tyrosine phosphorylation of the IGF-IR , IRS-1 , IRS-2 , or Shc . Negative_regulation AKT2 EPHB2 11445578 850510 Finally , examination of the phosphorylation state of Akt after HGF stimulation revealed that inhibition *resulted* in a decrease in [Akt] activation at both 5 and 10 min . Negative_regulation AKT2 EPHB2 12514175 1063815 Together , our data suggest that GDF-15 prevents apoptosis in CGN by activating [Akt] and *inhibiting* endogenously active . Negative_regulation AKT2 EPHB2 14978732 1213604 ( 2 ) the use of E-cadherin blocking antibodies efficiently prevents [Akt] phosphorylation and *inhibition* after 70 min of calcium restoration ; Negative_regulation AKT2 EPHB2 15351743 1292643 Expression of Gab1 PI3K-m in SK-N-MC human primitive neuroectodermal tumor cells expressing wild-type RET markedly impaired [Akt] phosphorylation , Rac1 activation , and lamellipodia formation that were *induced* by GDNF whereas expression of Gab1 SHP2-m partially impaired activation . Negative_regulation AKT2 EPHB2 15608143 1369085 MIP-2 activated extracellular signal regulated kinase ( ) 1/2 and [Akt] and both the mitogen activated protein kinase kinase 1 ( MEK1 ) and phosphatidylinositol 3-kinase (PI3K) *inhibitors* 2'-amino-3'-methoxyflavone ( PD98059 ) and wortmannin reduced the neuroprotective effect of MIP-2 . Negative_regulation AKT2 EPHB2 17418380 1748733 inhibition also significantly *increased* [Akt] phosphorylation under all conditions and decreased Smad-3 phosphorylation in the presence of IL-13+TGF-beta1 . Negative_regulation AKT2 EPHB2 18538131 1928839 OML induced phosphorylation was inhibited by specific inhibitors of PI3K and SFKs , and OML induced [Akt] phosphorylation was *inhibited* by a inhibitor of SFKs . Negative_regulation AKT2 EPHB2 19201774 2149169 All COX inhibitors attenuated activation , but only celecoxib significantly *inhibited* [Akt] activation in HSCs . Negative_regulation AKT2 EPHB2 19762915 2158782 In normal human chondrocytes , tBHP triggered strong IRS-1 ( Ser-312 and Ser-616 ) and phosphorylation and *inhibited* IGF-I induced IRS-1 ( Tyr-612 ) and [Akt] phosphorylation . Negative_regulation AKT2 EPHB2 19762915 2158845 Chemical inhibition of significantly *enhanced* IGF-I phosphorylation of [Akt] and alleviated tBHP inhibition of Akt phosphorylation . Negative_regulation AKT2 EPHB2 20512842 2270608 We found that low concentrations rapamycin increased Akt and phosphorylation through a mTORC1 dependent mechanism because knockdowned raptor induced the activation of Akt and ERK , but higher doses of rapamycin *inhibited* [Akt] and ERK phosphorylation mainly via the mTORC2 signaling pathway because that the silencing of rictor led to the inhibition of Akt and ERK phosphorylation . Negative_regulation AKT2 EPHB2 20714148 2312971 Sorafenib reduced c-Kit , and VEGFR2 activation and on the other hand , gemcitabine *inhibited* [Akt] phosphorylation . Negative_regulation AKT2 EPHB2 21148681 2390267 Inhibition of JNK , but not p38 MAPK and , *reduced* [Akt] phosphorylation . Negative_regulation AKT2 EPHB2 21529991 2489598 Sorafenib reduced c-Kit and activation and gemcitabine *inhibited* [Akt] phosphorylation . Negative_regulation AKT2 EPHB2 21945981 2507233 Exposure of SW480 cells to ECG led to apoptosis as determined by caspase-3 activity , imbalance among Bcl-2 anti- and pro-apoptotic protein levels , activation and [AKT] *inhibition* , whereas PB2 treatment enhanced phospho-AKT and phospho-ERK levels . Negative_regulation AKT2 EPHB2 22129743 2515087 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 mitogen activated protein kinase (MAPK) and [Akt] phosphorylation , but in contrast , *inhibited* that of ( 1/2 ) . Negative_regulation AKT2 EPHB2 22509025 2589537 By suppressing GRK expression with siRNA , we demonstrated that lowering GRK5/6 abolishes IGF1 mediated ERK and AKT activation , whereas GRK2 inhibition increases activation and partially *inhibits* [AKT] signaling . Negative_regulation AKT2 FAS 15806173 1417487 In contrast , inhibition of activity by the drug C75 *resulted* in downregulation of [phospho-AKT] and increased cell death . Negative_regulation AKT2 FAS 15806173 1417493 Treatment with LY294002 abolished [AKT] activity and potentiated apoptosis *induced* by inhibitors cerulenin or C75 only in cells with constitutively active AKT , suggesting that constitutive activation of AKT protects against FAS inhibitor induced cell death . Negative_regulation AKT2 FAS 15806173 1417496 Furthermore , inhibition of activity by cerulenin or C75 *resulted* in downregulation of [phospho-AKT] , which preceded the induction of apoptosis . Negative_regulation AKT2 FAS 25086185 2956911 Surprisingly , in *response* to suppression , we observed robust increases in both [Akt] and ERK phosphorylation . Negative_regulation AKT2 FBXO32 24002653 2856148 To accomplish this goal , in vivo transfection of plasmid DNA was used to create transient transgenic mouse skeletal muscles , and our results show for the first time that Smad3 expression is sufficient to stimulate promoter activity , *inhibit* [Akt/mTOR] signaling and protein synthesis , and induce muscle fiber atrophy . Negative_regulation AKT2 FOXO1 17210752 1681613 Interestingly , overexpression of constitutively active also *led* to activation of MEK and [Akt] phosphorylation . Negative_regulation AKT2 FOXO1 18077353 1836760 In addition , activity suppresses protein phosphatase 2A (PP2A) and *disrupts* [Akt-PP2A] and Akt-calcineurin interactions . Negative_regulation AKT2 FOXO1 21940942 2507177 Deacetylated *inhibits* free cholesterol induced [Akt] phosphorylation and increases levels of the nuclear factor-?B precursor p105 , decreasing nuclear translocation of nuclear factor-?B p65 subunit and dampening mitogen activated protein/extracellular signal regulated kinase activation to prevent inflammation . Negative_regulation AKT2 FOXO1 22515357 2584471 Infection with oipA mutants reduced PI3K/Akt activation and inhibited FoxO1/3a phosphorylation , whereas infection with cag PAI mutants reduced [PI3K/Akt] activity but did not *inhibit* activation . Negative_regulation AKT2 FOXO1 24453252 2913010 Our findings not only identify Mst kinases as the long-searched-for factors that simultaneously activate and *inhibit* TCR stimulated [Akt] downstream of TCR signaling to promote Foxp3 expression and Treg development , but also shed new light on understanding and designing better therapeutic strategies for MST1 deficiency mediated human immunodeficiency syndrome . Negative_regulation AKT2 FUT4 20506505 2307905 Results show that overexpression of *increases* the phosphorylation of ERK1/2 , p38 MAPK , and [PI3K/Akt] . Negative_regulation AKT2 HSD11B2 19675138 2150731 Selective <11beta-HSD1> inhibition decreases pSer ( 307 ) IRS1 , *increases* pThr ( 308 ) [Akt/PKB] , and decreases lipogenic and lipolytic gene expression that may represent an important mechanism underpinning their insulin sensitizing action . Negative_regulation AKT2 IFI27 16489017 1524898 Expression of in MCF7 breast cancer cells *down-regulated* RhoA and increased motility , survival , and [Akt] levels without an effect on cell cycle distribution . Negative_regulation AKT2 IFI27 19158484 2027270 Inhibition of ( Kip1 ) gene expression by PDGF *required* protein synthesis and histone deacetylase activity but not [Akt] or ERK activity . Negative_regulation AKT2 IFI27 20823108 2336470 Western blot analysis revealed that honokiol : ( i ) inhibited the levels of cyclins D1 , D2 and E and associated cyclin dependent kinases (CDKs)2 , CDK4 and CDK6 , ( ii ) upregulated Cip/p21 and and ( iii ) *inhibited* the levels of phosphatidylinositol 3-kinase and the phosphorylation of [Akt] at Ser ( 473 ) in UVB induced skin tumors . Negative_regulation AKT2 IL1B 11976320 953990 CaMKKc and [Akt] overexpression decreases IRAK1 mediated NF-kappaB activity and its association with MyD88 in *response* to stimulation . Negative_regulation AKT2 IL1B 16718462 1584829 A synthetic peptide , C3d , reported to bind NCAM , did not activate MAPK or [Akt] as reported in neurons but *inhibited* induced MAPK activity , thereby mimicking the effect of SU5402 . Negative_regulation AKT2 IL1B 17467122 1931671 In trophic support deprived neurons , compromised the PI3-K/Akt pathway mediated protection by BDNF and *suppressed* [Akt] activation . Negative_regulation AKT2 IL1B 20632386 2316668 Our results showed that GDNF resulted in a significant reduction in enhanced permeability , *inhibited* MPO activity , and TNF-alpha expression , and increased ZO-1 and [Akt] expression . Negative_regulation AKT2 IL1R2 22940184 2701661 A further study indicated that alantolactone attenuated the phosphorylation of [Akt] and *inhibited* the expression of MyD88 and domain containing adaptor protein ( TIRAP ) , an upstream signaling molecule required for IKK and MAPKs activation . Negative_regulation AKT2 IRS4 19029952 2029397 Once expressed , as well as binding to E1A and the insulin receptor , remains tyrosine phosphorylated and constitutively associates with the regulatory p85 subunit of phosphoinositide 3 kinase , *resulting* in the phosphorylation of [Akt] ( causing activation ) and GSK-3beta ( causing inhibition ) . Negative_regulation AKT2 KLF9 24737412 2936310 Intriguingly , expression severely *suppressed* the activation of [AKT] and its downstream targets . Negative_regulation AKT2 KLF9 24737412 2936313 These data collectively showing that substantially *inhibits* [AKT] activation and abrogates tumor growth of PCa cells , suggest the potential of either genetic or pharmacological activation of KLF9 in the therapeutic treatment of castration-resistant PCa . Negative_regulation AKT2 MAP2K6 14978732 1213610 ( 2 ) the use of E-cadherin blocking antibodies efficiently prevents [Akt] phosphorylation and *inhibition* after 70 min of calcium restoration ; Negative_regulation AKT2 MAP2K6 15177934 1255151 The effects of NT on [EGFR/ERK/Akt] activation and DNA synthesis were *attenuated* by PLC-inhibitor ( U73122 ) , PKC-inhibitors ( bisindolylmaleimide , staurosporine , rottlerin ) , inhibitor ( U0126 ) and PI3 kinase inhibitors ( wortmannin , LY 294002 ) . Negative_regulation AKT2 MAP2K6 15361836 1303946 or PI3K inhibitors *suppressed* ERK or [Akt] activation , respectively , and induced apoptosis in the v-ErbB : ER-responsive cells . Negative_regulation AKT2 MAP2K6 17418380 1748739 inhibition also significantly *increased* [Akt] phosphorylation under all conditions and decreased Smad-3 phosphorylation in the presence of IL-13+TGF-beta1 . Negative_regulation AKT2 MAP2K6 22552284 2618765 inhibition *leads* to [PI3K/AKT] activation by relieving a negative feedback on ERBB receptors . Negative_regulation AKT2 MAP2K6 22552284 2618800 In this study , we describe a feedback mechanism in which inhibition *leads* to activation of [PI3K/AKT] signaling in EGFR and HER2-driven cancers . Negative_regulation AKT2 MAP2K6 22561840 2608750 We found that the [phospho-Akt] level under the Raf mutation was remarkably *augmented* by inhibitor , while the phospho-ERK level was almost completely repressed . Negative_regulation AKT2 PECAM1 15985432 1441177 Tie2 and expression decreased > 80 % after siRNA treatment , and flow stimulated phosphorylation of ERK1/2 , [Akt] , and endothelial nitric oxide synthase was significantly *inhibited* by Tie2 and PECAM1 siRNA . Negative_regulation AKT2 PECAM1 16118242 1454341 *Role* of in the shear-stress induced activation of [Akt] and the endothelial nitric oxide synthase (eNOS) in endothelial cells . Negative_regulation AKT2 PLAU 23615713 2804728 In addition , avß6 integrin *induced* the phosphorylation of p38 MAPK and PI3 [K/Akt] , contributing to the up-regulation of uPA , as treatment with the specific inhibitor for p38 mitogen activated protein kinases (MAPK) ( SB203580 ) or phosphatidylinositol 3-kinase (PI3 K)/Akt ( LY294002 ) strikingly abrogated expression . Negative_regulation AKT2 RGS16 19509421 2115976 overexpression in MCF7 breast cancer cells *inhibited* EGF induced proliferation and [Akt] phosphorylation , whereas shRNA mediated extinction of RGS16 augmented cell growth and resistance to TKI treatment . Negative_regulation AKT2 RGS2 15536149 1367478 also *inhibited* Flt3-ITD induced phosphorylation of [Akt] and glycogen synthase kinase beta ( Gsk3-beta ) without influencing signal transducer and activator of transcription 5 ( STAT5 ) activation . Negative_regulation AKT2 RGS2 20362664 2261065 overexpression also significantly *attenuated* ISO induced extracellular signal regulated kinases 1 and 2 ( ERK1/2 ) and [Akt] activation , which may account for , or contribute to , its observed antihypertrophic effects . Negative_regulation AKT2 S100B 21130124 2413991 Moreover , *reduces* myoblast apoptosis in an MEK-ERK1/2 , [Akt] , JNK , and NF-?B dependent manner . Negative_regulation AKT2 SPHK1 15993704 1429708 Inhibition of SPHK-1 also did not affect EGF stimulated phosphorylation of PI-3 kinase , [Akt] , ERK1/2 or p38 but inhibition of PI-3 kinase with a specific inhibitor LY294002 partly ( 40 % ) *inhibited* the EGF stimulated increase in activity . Negative_regulation AKT2 TCN1 19422047 2096126 Here , we demonstrate that *inhibits* Akt phosphorylation at Thr308 and Ser473 and [Akt] activity in the human prostate cancer cell line PC-3 . Negative_regulation AKT2 TCN1 20489726 2327384 The Akt activation inhibitor *inhibits* [Akt] phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane . Negative_regulation AKT2 TCN1 20489726 2327390 Triciribine (TCN) phosphate ( TCN-P ) , the active metabolite of the Akt phosphorylation inhibitor TCN , is in clinical trials , but the mechanism by which *inhibits* [Akt] phosphorylation is unknown . Negative_regulation AKT2 TCN1 20489726 2327396 Here we show that in vitro , *inhibits* neither [Akt] activity nor the phosphorylation of Akt S473 and T308 by mammalian target of rapamycin or phosphoinositide dependent kinase 1 . Negative_regulation AKT2 TCN1 20489726 2327402 However , in intact cells , *inhibits* EGF stimulated [Akt] recruitment to the plasma membrane and phosphorylation of Akt . Negative_regulation AKT2 TCN1 23993427 2862083 In this phase I/II study of , a small-molecule [Akt] *inhibitor* , TCN-PM therapy was well tolerated in patients with advanced hematological malignancies , and reduced levels of phosphorylation of Akt and its substrate Bad were shown , consistent with inhibition of this survival pathway and induction of cell death . Negative_regulation AKT2 TFPI2 24591127 2886376 Furthermore , silencing of *caused* increased [Akt] phosphorylation level and NF-?B transcription in MHCC97-L cells . Negative_regulation AKT2 TLR7 24251781 2903701 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , [PI3K/AkT] *inhibition* , IKK/JNK inhibition , mTORC1 inhibition , JAK/STAT inhibition , suppression , and ACE inhibition . Negative_regulation AKT2 TNF 11067939 747590 In the presence of TNF-alpha , [Akt] activity was enhanced , and CPPD crystal induced activation of ERK1 and ERK2 was more sustained than with CPPD crystals alone , but itself *reduced* the basal phosphotransferase activities of these MAP kinases . Negative_regulation AKT2 TNF 11563846 863019 Insulin induced phosphorylation of [Akt] downstream of PI3K was *inhibited* by in a similar pattern . Negative_regulation AKT2 TNF 12089369 959670 p38 MAPK inhibition with 10 microM SB202190 that also decreased ANCA induced superoxide generation prevented S473 phosphorylation of [Akt] in *response* to and to ANCA . Negative_regulation AKT2 TNF 15646653 1349881 Stimulation of human neutrophils with granulocyte colony stimulating factor ( G-CSF ) , granulocyte-macrophage CSF (GM-CSF) , or *resulted* in phosphorylation of [Akt] , the potency being GM-CSF > G-CSF = TNF , which was inhibited by wortmannin . Negative_regulation AKT2 TNF 16712794 1564774 On the other hand , addition of or IL-6 neutralizing antibodies to the supernatant of co-culture *recovered* both IRS-2 phosphorylation and [Akt] activation . Negative_regulation AKT2 TNF 17264149 1696907 Disrupting signaling by TNF-alpha neutralizing antibody or knocking out TNF-alpha receptors *blocked* stretch activation of p38 , but not ERK1/2 , JNK or [AKT] . Negative_regulation AKT2 TNF 17449583 1730015 At the molecular level , quercetin inhibited [Akt] phosphorylation but did not *inhibit* TNF induced RelA/I-kappaB phosphorylation and IkappaB degradation or induced nuclear factor-kappaB transcriptional activity . Negative_regulation AKT2 TNF 19001549 2016189 The expression of DeltaIP-PTEN enhanced the phosphorylation of Akt1 at 120 min and that of Akt2 at 2 min. Interestingly , the expression of DeltaIP-SHIP2 , but not DeltaIP-PTEN , protected against the *inhibition* of insulin induced phosphorylation of [Akt2] , GSK3 , and AS160 , whereas both improved the TNF-alpha inhibition of insulin induced 2-deoxyglucose uptake . Negative_regulation AKT2 TNF 19118509 2004813 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and and *inhibited* the phosphorylation of [Akt] , PKCdelta and p38 mitogen activated protein kinase (MAPK) . Negative_regulation AKT2 TNF 19782747 2183815 We found that a reduction in PKCdelta protein levels reversed the *mediated* reduction in insulin stimulated IRS-1 Tyr phosphorylation , [Akt] activation , and glycogen synthesis . Negative_regulation AKT2 TNF 19801900 2148208 Vaspin did not inhibit the ( 20 min ) activation of JNK , p38 and NF-kappaB , but only slightly *inhibited* [Akt] . Negative_regulation AKT2 TNF 20048146 2211534 Staurosporine , , or a Fas ligand *inhibited* both RVI and hypertonicity induced [Akt] activation in a manner sensitive to a scavenger for reactive oxygen species ( ROS ) . Negative_regulation AKT2 TNF 20164250 2227812 IL-6 and , but not IL-1beta , *inhibited* [Akt] phosphorylation within 15 min of insulin stimulation , but only IL-6 was inhibitory 30 min after stimulation . Negative_regulation AKT2 TNF 20208423 2265453 The *induced* suppression of the tyrosine phosphorylation of the insulin receptor substrate-1 (IRS-1) and [Akt] in 3T3-L1 adipocytes was also reversed by SAM . Negative_regulation AKT2 TNF 20632386 2316667 Our results showed that GDNF resulted in a significant reduction in enhanced permeability , *inhibited* MPO activity , IL-1beta and expression , and increased ZO-1 and [Akt] expression . Negative_regulation AKT2 TNF 21282635 2393020 Both FFAs and *induce* an [Akt] inhibitor , carboxyl-terminal modulator protein ( CTMP ) . Negative_regulation AKT2 TNF 22223859 2559165 Further studies showed that decreased expression of the antiapoptotic proteins Bcl-2 and Bcl-xL , decreased I?Ba and PPAR? , and also *inhibited* PI3K dependent [Akt] and EGFR signaling . Negative_regulation AKT2 TNF 22266196 2559754 DAG also reversed or attenuated the *induced* reduction in phosphorylation of [Akt] , FOXO1 , 4E-BP-1 , and GSK-3ß in myotubes . Negative_regulation AKT2 TNFSF10 11992615 938779 In addition , combined and wortmannin treatment *resulted* in cleavage of several proteins : PARP , [Akt] , p21/WAF1 , and MDM2 as well as dephosphorylation of Akt . Negative_regulation AKT2 TNFSF10 18457369 1909359 Clematis mandshurica prevents *induced* down-regulation of 14-3-3 and phosphorylated [Akt] . Negative_regulation AKT2 TNFSF10 20113484 2213106 The combination of GGTI-298 and TRAIL was more effective than each single agent in decreasing the levels of IkappaBalpha and p-Akt , implying that activates NF-kappaB and *inhibits* [Akt] . Negative_regulation AKT2 TNFSF10 22321426 2520716 To study the effects of combinative therapy of tumor necrosis factor related apoptosis inducing ligand ( ) and [PI3-K-Akt] *inhibitor* on the growth and apoptosis of nasopharyngeal carcinoma (NPC) cells and underlying mechanisms . Negative_regulation AKT2 TNFSF10 22998497 2720110 Interestingly , while *induces* a significant reduction in the levels of [phospho-Akt] ( pAkt ) and phospho-MADD ( pMADD ) in TRAIL-sensitive cells , it fails to do so in TRAIL-resistant cells . Negative_regulation AKT2 TNFSF10 24556678 2919245 Furthermore , thioridazine increased the production of reactive oxygen species ( ROS ) in Caki cells , and ROS scavengers ( N-acetylcysteine , glutathione ethyl ester , and trolox ) inhibited thioridazine plus induced apoptosis , as well as [Akt] *inhibition* and the downregulation of c-FLIP ( L ) and Mcl-1 . Negative_regulation AKT3 ARSA 23867870 2830027 Therefore , <5-ASA> reduces CUC induced reactive oxygen species in colonic progenitor cells and enhances PTEN activity , thus *attenuating* [PI3K/Akt] signaling . Negative_regulation AKT3 CAPN8 20347887 2266315 Interestingly , inhibitors of proteosome , or caspase mediated proteolysis did not significantly *block* [AKT] loss . Negative_regulation AKT3 CCND1 20529342 2277416 The molecular analysis of tumor samples and in vitro experiments indicated that MTA induces cytostatic rather than pro-apoptotic effects inhibiting the phosphorylation of [Akt] and S6 ribosomal protein and *inducing* the down-regulation of . Negative_regulation AKT3 CCND1 23237355 2711146 Essential oil activated the caspase dependent apoptotic pathway , *induced* a rapid and transient activation of [Akt] and Erk1/2 , and suppressed levels of expression in cultured pancreatic cancer cells . Negative_regulation AKT3 CCND1 24596136 2955915 Baicalein induced G0/G1-phase arrest in hepatocellular carcinoma cells , *inhibited* [AKT] , and promoted the degradation of ß-catenin and without activation of GSK-3ß . Negative_regulation AKT3 EPHB2 10629859 576453 Expression of GRK2-ct inhibited the H2O2 induced activation of by 70 % and also *inhibited* the activation of [Akt] by 30 % . Negative_regulation AKT3 EPHB2 11228049 763990 PD98059 inhibited activation of and LY294002 *repressed* activation of [Akt] in response to IGF-I , but did not affect tyrosine phosphorylation of the IGF-IR , IRS-1 , IRS-2 , or Shc . Negative_regulation AKT3 EPHB2 11445578 850511 Finally , examination of the phosphorylation state of Akt after HGF stimulation revealed that inhibition *resulted* in a decrease in [Akt] activation at both 5 and 10 min . Negative_regulation AKT3 EPHB2 12514175 1063816 Together , our data suggest that GDF-15 prevents apoptosis in CGN by activating [Akt] and *inhibiting* endogenously active . Negative_regulation AKT3 EPHB2 14978732 1213612 ( 2 ) the use of E-cadherin blocking antibodies efficiently prevents [Akt] phosphorylation and *inhibition* after 70 min of calcium restoration ; Negative_regulation AKT3 EPHB2 15351743 1292647 Expression of Gab1 PI3K-m in SK-N-MC human primitive neuroectodermal tumor cells expressing wild-type RET markedly impaired [Akt] phosphorylation , Rac1 activation , and lamellipodia formation that were *induced* by GDNF whereas expression of Gab1 SHP2-m partially impaired activation . Negative_regulation AKT3 EPHB2 15608143 1369087 MIP-2 activated extracellular signal regulated kinase ( ) 1/2 and [Akt] and both the mitogen activated protein kinase kinase 1 ( MEK1 ) and phosphatidylinositol 3-kinase (PI3K) *inhibitors* 2'-amino-3'-methoxyflavone ( PD98059 ) and wortmannin reduced the neuroprotective effect of MIP-2 . Negative_regulation AKT3 EPHB2 17418380 1748741 inhibition also significantly *increased* [Akt] phosphorylation under all conditions and decreased Smad-3 phosphorylation in the presence of IL-13+TGF-beta1 . Negative_regulation AKT3 EPHB2 18538131 1928840 OML induced phosphorylation was inhibited by specific inhibitors of PI3K and SFKs , and OML induced [Akt] phosphorylation was *inhibited* by a inhibitor of SFKs . Negative_regulation AKT3 EPHB2 19201774 2149170 All COX inhibitors attenuated activation , but only celecoxib significantly *inhibited* [Akt] activation in HSCs . Negative_regulation AKT3 EPHB2 19762915 2158784 In normal human chondrocytes , tBHP triggered strong IRS-1 ( Ser-312 and Ser-616 ) and phosphorylation and *inhibited* IGF-I induced IRS-1 ( Tyr-612 ) and [Akt] phosphorylation . Negative_regulation AKT3 EPHB2 19762915 2158846 Chemical inhibition of significantly *enhanced* IGF-I phosphorylation of [Akt] and alleviated tBHP inhibition of Akt phosphorylation . Negative_regulation AKT3 EPHB2 20512842 2270609 We found that low concentrations rapamycin increased Akt and phosphorylation through a mTORC1 dependent mechanism because knockdowned raptor induced the activation of Akt and ERK , but higher doses of rapamycin *inhibited* [Akt] and ERK phosphorylation mainly via the mTORC2 signaling pathway because that the silencing of rictor led to the inhibition of Akt and ERK phosphorylation . Negative_regulation AKT3 EPHB2 20714148 2312973 Sorafenib reduced c-Kit , and VEGFR2 activation and on the other hand , gemcitabine *inhibited* [Akt] phosphorylation . Negative_regulation AKT3 EPHB2 21148681 2390281 Inhibition of JNK , but not p38 MAPK and , *reduced* [Akt] phosphorylation . Negative_regulation AKT3 EPHB2 21529991 2489599 Sorafenib reduced c-Kit and activation and gemcitabine *inhibited* [Akt] phosphorylation . Negative_regulation AKT3 EPHB2 21945981 2507234 Exposure of SW480 cells to ECG led to apoptosis as determined by caspase-3 activity , imbalance among Bcl-2 anti- and pro-apoptotic protein levels , activation and [AKT] *inhibition* , whereas PB2 treatment enhanced phospho-AKT and phospho-ERK levels . Negative_regulation AKT3 EPHB2 22129743 2515088 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 mitogen activated protein kinase (MAPK) and [Akt] phosphorylation , but in contrast , *inhibited* that of ( 1/2 ) . Negative_regulation AKT3 EPHB2 22509025 2589538 By suppressing GRK expression with siRNA , we demonstrated that lowering GRK5/6 abolishes IGF1 mediated ERK and AKT activation , whereas GRK2 inhibition increases activation and partially *inhibits* [AKT] signaling . Negative_regulation AKT3 FAS 15806173 1417488 In contrast , inhibition of activity by the drug C75 *resulted* in downregulation of [phospho-AKT] and increased cell death . Negative_regulation AKT3 FAS 15806173 1417494 Treatment with LY294002 abolished [AKT] activity and potentiated apoptosis *induced* by inhibitors cerulenin or C75 only in cells with constitutively active AKT , suggesting that constitutive activation of AKT protects against FAS inhibitor induced cell death . Negative_regulation AKT3 FAS 15806173 1417497 Furthermore , inhibition of activity by cerulenin or C75 *resulted* in downregulation of [phospho-AKT] , which preceded the induction of apoptosis . Negative_regulation AKT3 FAS 25086185 2956912 Surprisingly , in *response* to suppression , we observed robust increases in both [Akt] and ERK phosphorylation . Negative_regulation AKT3 FBXO32 24002653 2856150 To accomplish this goal , in vivo transfection of plasmid DNA was used to create transient transgenic mouse skeletal muscles , and our results show for the first time that Smad3 expression is sufficient to stimulate promoter activity , *inhibit* [Akt/mTOR] signaling and protein synthesis , and induce muscle fiber atrophy . Negative_regulation AKT3 FOXO1 17210752 1681614 Interestingly , overexpression of constitutively active also *led* to activation of MEK and [Akt] phosphorylation . Negative_regulation AKT3 FOXO1 18077353 1836764 In addition , activity suppresses protein phosphatase 2A (PP2A) and *disrupts* [Akt-PP2A] and Akt-calcineurin interactions . Negative_regulation AKT3 FOXO1 21940942 2507178 Deacetylated *inhibits* free cholesterol induced [Akt] phosphorylation and increases levels of the nuclear factor-?B precursor p105 , decreasing nuclear translocation of nuclear factor-?B p65 subunit and dampening mitogen activated protein/extracellular signal regulated kinase activation to prevent inflammation . Negative_regulation AKT3 FOXO1 22515357 2584473 Infection with oipA mutants reduced PI3K/Akt activation and inhibited FoxO1/3a phosphorylation , whereas infection with cag PAI mutants reduced [PI3K/Akt] activity but did not *inhibit* activation . Negative_regulation AKT3 FOXO1 24453252 2913012 Our findings not only identify Mst kinases as the long-searched-for factors that simultaneously activate and *inhibit* TCR stimulated [Akt] downstream of TCR signaling to promote Foxp3 expression and Treg development , but also shed new light on understanding and designing better therapeutic strategies for MST1 deficiency mediated human immunodeficiency syndrome . Negative_regulation AKT3 FUT4 20506505 2307906 Results show that overexpression of *increases* the phosphorylation of ERK1/2 , p38 MAPK , and [PI3K/Akt] . Negative_regulation AKT3 HSD11B2 19675138 2150732 Selective <11beta-HSD1> inhibition decreases pSer ( 307 ) IRS1 , *increases* pThr ( 308 ) [Akt/PKB] , and decreases lipogenic and lipolytic gene expression that may represent an important mechanism underpinning their insulin sensitizing action . Negative_regulation AKT3 IFI27 16489017 1524899 Expression of in MCF7 breast cancer cells *down-regulated* RhoA and increased motility , survival , and [Akt] levels without an effect on cell cycle distribution . Negative_regulation AKT3 IFI27 19158484 2027271 Inhibition of ( Kip1 ) gene expression by PDGF *required* protein synthesis and histone deacetylase activity but not [Akt] or ERK activity . Negative_regulation AKT3 IFI27 20823108 2336473 Western blot analysis revealed that honokiol : ( i ) inhibited the levels of cyclins D1 , D2 and E and associated cyclin dependent kinases (CDKs)2 , CDK4 and CDK6 , ( ii ) upregulated Cip/p21 and and ( iii ) *inhibited* the levels of phosphatidylinositol 3-kinase and the phosphorylation of [Akt] at Ser ( 473 ) in UVB induced skin tumors . Negative_regulation AKT3 IL1B 11976320 953991 CaMKKc and [Akt] overexpression decreases IRAK1 mediated NF-kappaB activity and its association with MyD88 in *response* to stimulation . Negative_regulation AKT3 IL1B 16718462 1584843 A synthetic peptide , C3d , reported to bind NCAM , did not activate MAPK or [Akt] as reported in neurons but *inhibited* induced MAPK activity , thereby mimicking the effect of SU5402 . Negative_regulation AKT3 IL1B 17467122 1931672 In trophic support deprived neurons , compromised the PI3-K/Akt pathway mediated protection by BDNF and *suppressed* [Akt] activation . Negative_regulation AKT3 IL1B 20632386 2316671 Our results showed that GDNF resulted in a significant reduction in enhanced permeability , *inhibited* MPO activity , and TNF-alpha expression , and increased ZO-1 and [Akt] expression . Negative_regulation AKT3 IL1R2 22940184 2701665 A further study indicated that alantolactone attenuated the phosphorylation of [Akt] and *inhibited* the expression of MyD88 and domain containing adaptor protein ( TIRAP ) , an upstream signaling molecule required for IKK and MAPKs activation . Negative_regulation AKT3 IRS4 19029952 2029398 Once expressed , as well as binding to E1A and the insulin receptor , remains tyrosine phosphorylated and constitutively associates with the regulatory p85 subunit of phosphoinositide 3 kinase , *resulting* in the phosphorylation of [Akt] ( causing activation ) and GSK-3beta ( causing inhibition ) . Negative_regulation AKT3 KLF9 24737412 2936311 Intriguingly , expression severely *suppressed* the activation of [AKT] and its downstream targets . Negative_regulation AKT3 KLF9 24737412 2936314 These data collectively showing that substantially *inhibits* [AKT] activation and abrogates tumor growth of PCa cells , suggest the potential of either genetic or pharmacological activation of KLF9 in the therapeutic treatment of castration-resistant PCa . Negative_regulation AKT3 MAP2K6 14978732 1213618 ( 2 ) the use of E-cadherin blocking antibodies efficiently prevents [Akt] phosphorylation and *inhibition* after 70 min of calcium restoration ; Negative_regulation AKT3 MAP2K6 15177934 1255159 The effects of NT on [EGFR/ERK/Akt] activation and DNA synthesis were *attenuated* by PLC-inhibitor ( U73122 ) , PKC-inhibitors ( bisindolylmaleimide , staurosporine , rottlerin ) , inhibitor ( U0126 ) and PI3 kinase inhibitors ( wortmannin , LY 294002 ) . Negative_regulation AKT3 MAP2K6 15361836 1303953 or PI3K inhibitors *suppressed* ERK or [Akt] activation , respectively , and induced apoptosis in the v-ErbB : ER-responsive cells . Negative_regulation AKT3 MAP2K6 17418380 1748747 inhibition also significantly *increased* [Akt] phosphorylation under all conditions and decreased Smad-3 phosphorylation in the presence of IL-13+TGF-beta1 . Negative_regulation AKT3 MAP2K6 22552284 2618772 inhibition *leads* to [PI3K/AKT] activation by relieving a negative feedback on ERBB receptors . Negative_regulation AKT3 MAP2K6 22552284 2618807 In this study , we describe a feedback mechanism in which inhibition *leads* to activation of [PI3K/AKT] signaling in EGFR and HER2-driven cancers . Negative_regulation AKT3 MAP2K6 22561840 2608757 We found that the [phospho-Akt] level under the Raf mutation was remarkably *augmented* by inhibitor , while the phospho-ERK level was almost completely repressed . Negative_regulation AKT3 PECAM1 15985432 1441179 Tie2 and expression decreased > 80 % after siRNA treatment , and flow stimulated phosphorylation of ERK1/2 , [Akt] , and endothelial nitric oxide synthase was significantly *inhibited* by Tie2 and PECAM1 siRNA . Negative_regulation AKT3 PECAM1 16118242 1454342 *Role* of in the shear-stress induced activation of [Akt] and the endothelial nitric oxide synthase (eNOS) in endothelial cells . Negative_regulation AKT3 PLAU 23615713 2804729 In addition , avß6 integrin *induced* the phosphorylation of p38 MAPK and PI3 [K/Akt] , contributing to the up-regulation of uPA , as treatment with the specific inhibitor for p38 mitogen activated protein kinases (MAPK) ( SB203580 ) or phosphatidylinositol 3-kinase (PI3 K)/Akt ( LY294002 ) strikingly abrogated expression . Negative_regulation AKT3 RGS16 19509421 2115977 overexpression in MCF7 breast cancer cells *inhibited* EGF induced proliferation and [Akt] phosphorylation , whereas shRNA mediated extinction of RGS16 augmented cell growth and resistance to TKI treatment . Negative_regulation AKT3 RGS2 15536149 1367479 also *inhibited* Flt3-ITD induced phosphorylation of [Akt] and glycogen synthase kinase beta ( Gsk3-beta ) without influencing signal transducer and activator of transcription 5 ( STAT5 ) activation . Negative_regulation AKT3 RGS2 20362664 2261066 overexpression also significantly *attenuated* ISO induced extracellular signal regulated kinases 1 and 2 ( ERK1/2 ) and [Akt] activation , which may account for , or contribute to , its observed antihypertrophic effects . Negative_regulation AKT3 S100B 21130124 2413992 Moreover , *reduces* myoblast apoptosis in an MEK-ERK1/2 , [Akt] , JNK , and NF-?B dependent manner . Negative_regulation AKT3 SPHK1 15993704 1429710 Inhibition of SPHK-1 also did not affect EGF stimulated phosphorylation of PI-3 kinase , [Akt] , ERK1/2 or p38 but inhibition of PI-3 kinase with a specific inhibitor LY294002 partly ( 40 % ) *inhibited* the EGF stimulated increase in activity . Negative_regulation AKT3 TCN1 19422047 2096128 Here , we demonstrate that *inhibits* Akt phosphorylation at Thr308 and Ser473 and [Akt] activity in the human prostate cancer cell line PC-3 . Negative_regulation AKT3 TCN1 20489726 2327386 The Akt activation inhibitor *inhibits* [Akt] phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane . Negative_regulation AKT3 TCN1 20489726 2327392 Triciribine (TCN) phosphate ( TCN-P ) , the active metabolite of the Akt phosphorylation inhibitor TCN , is in clinical trials , but the mechanism by which *inhibits* [Akt] phosphorylation is unknown . Negative_regulation AKT3 TCN1 20489726 2327398 Here we show that in vitro , *inhibits* neither [Akt] activity nor the phosphorylation of Akt S473 and T308 by mammalian target of rapamycin or phosphoinositide dependent kinase 1 . Negative_regulation AKT3 TCN1 20489726 2327404 However , in intact cells , *inhibits* EGF stimulated [Akt] recruitment to the plasma membrane and phosphorylation of Akt . Negative_regulation AKT3 TCN1 23993427 2862085 In this phase I/II study of , a small-molecule [Akt] *inhibitor* , TCN-PM therapy was well tolerated in patients with advanced hematological malignancies , and reduced levels of phosphorylation of Akt and its substrate Bad were shown , consistent with inhibition of this survival pathway and induction of cell death . Negative_regulation AKT3 TFPI2 24591127 2886377 Furthermore , silencing of *caused* increased [Akt] phosphorylation level and NF-?B transcription in MHCC97-L cells . Negative_regulation AKT3 TLR7 24251781 2903728 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , [PI3K/AkT] *inhibition* , IKK/JNK inhibition , mTORC1 inhibition , JAK/STAT inhibition , suppression , and ACE inhibition . Negative_regulation AKT3 TNF 11067939 747591 In the presence of TNF-alpha , [Akt] activity was enhanced , and CPPD crystal induced activation of ERK1 and ERK2 was more sustained than with CPPD crystals alone , but itself *reduced* the basal phosphotransferase activities of these MAP kinases . Negative_regulation AKT3 TNF 11563846 863020 Insulin induced phosphorylation of [Akt] downstream of PI3K was *inhibited* by in a similar pattern . Negative_regulation AKT3 TNF 12089369 959671 p38 MAPK inhibition with 10 microM SB202190 that also decreased ANCA induced superoxide generation prevented S473 phosphorylation of [Akt] in *response* to and to ANCA . Negative_regulation AKT3 TNF 15646653 1349884 Stimulation of human neutrophils with granulocyte colony stimulating factor ( G-CSF ) , granulocyte-macrophage CSF (GM-CSF) , or *resulted* in phosphorylation of [Akt] , the potency being GM-CSF > G-CSF = TNF , which was inhibited by wortmannin . Negative_regulation AKT3 TNF 16712794 1564776 On the other hand , addition of or IL-6 neutralizing antibodies to the supernatant of co-culture *recovered* both IRS-2 phosphorylation and [Akt] activation . Negative_regulation AKT3 TNF 17264149 1696908 Disrupting signaling by TNF-alpha neutralizing antibody or knocking out TNF-alpha receptors *blocked* stretch activation of p38 , but not ERK1/2 , JNK or [AKT] . Negative_regulation AKT3 TNF 17449583 1730017 At the molecular level , quercetin inhibited [Akt] phosphorylation but did not *inhibit* TNF induced RelA/I-kappaB phosphorylation and IkappaB degradation or induced nuclear factor-kappaB transcriptional activity . Negative_regulation AKT3 TNF 19118509 2004816 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and and *inhibited* the phosphorylation of [Akt] , PKCdelta and p38 mitogen activated protein kinase (MAPK) . Negative_regulation AKT3 TNF 19782747 2183816 We found that a reduction in PKCdelta protein levels reversed the *mediated* reduction in insulin stimulated IRS-1 Tyr phosphorylation , [Akt] activation , and glycogen synthesis . Negative_regulation AKT3 TNF 19801900 2148213 Vaspin did not inhibit the ( 20 min ) activation of JNK , p38 and NF-kappaB , but only slightly *inhibited* [Akt] . Negative_regulation AKT3 TNF 20048146 2211536 Staurosporine , , or a Fas ligand *inhibited* both RVI and hypertonicity induced [Akt] activation in a manner sensitive to a scavenger for reactive oxygen species ( ROS ) . Negative_regulation AKT3 TNF 20164250 2227814 IL-6 and , but not IL-1beta , *inhibited* [Akt] phosphorylation within 15 min of insulin stimulation , but only IL-6 was inhibitory 30 min after stimulation . Negative_regulation AKT3 TNF 20208423 2265454 The *induced* suppression of the tyrosine phosphorylation of the insulin receptor substrate-1 (IRS-1) and [Akt] in 3T3-L1 adipocytes was also reversed by SAM . Negative_regulation AKT3 TNF 20632386 2316670 Our results showed that GDNF resulted in a significant reduction in enhanced permeability , *inhibited* MPO activity , IL-1beta and expression , and increased ZO-1 and [Akt] expression . Negative_regulation AKT3 TNF 21282635 2393022 Both FFAs and *induce* an [Akt] inhibitor , carboxyl-terminal modulator protein ( CTMP ) . Negative_regulation AKT3 TNF 22223859 2559172 Further studies showed that decreased expression of the antiapoptotic proteins Bcl-2 and Bcl-xL , decreased I?Ba and PPAR? , and also *inhibited* PI3K dependent [Akt] and EGFR signaling . Negative_regulation AKT3 TNF 22266196 2559755 DAG also reversed or attenuated the *induced* reduction in phosphorylation of [Akt] , FOXO1 , 4E-BP-1 , and GSK-3ß in myotubes . Negative_regulation AKT3 TNFSF10 11992615 938780 In addition , combined and wortmannin treatment *resulted* in cleavage of several proteins : PARP , [Akt] , p21/WAF1 , and MDM2 as well as dephosphorylation of Akt . Negative_regulation AKT3 TNFSF10 18457369 1909360 Clematis mandshurica prevents *induced* down-regulation of 14-3-3 and phosphorylated [Akt] . Negative_regulation AKT3 TNFSF10 20113484 2213109 The combination of GGTI-298 and TRAIL was more effective than each single agent in decreasing the levels of IkappaBalpha and p-Akt , implying that activates NF-kappaB and *inhibits* [Akt] . Negative_regulation AKT3 TNFSF10 22321426 2520717 To study the effects of combinative therapy of tumor necrosis factor related apoptosis inducing ligand ( ) and [PI3-K-Akt] *inhibitor* on the growth and apoptosis of nasopharyngeal carcinoma (NPC) cells and underlying mechanisms . Negative_regulation AKT3 TNFSF10 22998497 2720111 Interestingly , while *induces* a significant reduction in the levels of [phospho-Akt] ( pAkt ) and phospho-MADD ( pMADD ) in TRAIL-sensitive cells , it fails to do so in TRAIL-resistant cells . Negative_regulation AKT3 TNFSF10 24556678 2919246 Furthermore , thioridazine increased the production of reactive oxygen species ( ROS ) in Caki cells , and ROS scavengers ( N-acetylcysteine , glutathione ethyl ester , and trolox ) inhibited thioridazine plus induced apoptosis , as well as [Akt] *inhibition* and the downregulation of c-FLIP ( L ) and Mcl-1 . Negative_regulation ALAS1 FOXO1 22070747 2548056 [ALAS1] gene expression is *down-regulated* by Akt mediated phosphorylation and nuclear exclusion of by vanadate in diabetic mice . Negative_regulation ALAS1 IL1B 10433360 633986 *suppressed* the microsomal total P450 and heme contents and [delta-ALAS] activity in the liver . Negative_regulation ALAS1 IL1B 10433360 633988 *inhibited* both allylisopropylamide- and phenobarbital-inducible [delta-ALAS] activities in the liver . Negative_regulation ALB FAS 18088500 1847346 In-vitro , *inhibited* the binding of flurbiprofen to rat [serum albumin] . Negative_regulation ALB HBEGF 10213920 608097 selectively suppressed the AFP enhancer activity , resulting in decreased *levels* of both [albumin] and AFP mRNA in HuH-7 cells . Negative_regulation ALB HES2 10866254 705969 also *reduced* [albumin] synthesis . Negative_regulation ALB IL1B 12202007 983013 ( 10 ng/mL ) *inhibited* [albumin] ( -90 % ) , urea ( -40 to 50 % ) , and IL-6 stimulated fibrinogen ( -90 % ) secretion . Negative_regulation ALB IL1B 2468672 109367 Recombinant human *mediates* an increase in synthesis of the positive acute phase complement protein factor B and a decrease in synthesis of negative acute phase protein [albumin] in the parent uncloned HepG2 cell line ( HG2Y ) , but not in the subclone HG2N . Negative_regulation ALB TF 2475226 115150 AFP and [albumin] levels in HuH-6 and HuH-7 were *reduced* or unchanged by fetuin , bovine serum albumin ( BSA ) and , although no cytotoxicity was shown by any of them . Negative_regulation ALB TNF 10374487 478568 Endotoxin *inhibited* [albumin] mRNA expression in vivo probably by stimulating , IL-1 , and IL-6 production . Negative_regulation ALB TNF 1505918 196408 Pure interleukin-1 , interleukin-6 and also *inhibited* [albumin] synthesis ( p less than 0.05 , Wilcoxon 's rank sum test , n = 5 ) , interleukin-6 having the greatest effect . Negative_regulation ALB TNF 2295699 127548 *inhibits* [albumin] gene expression in a murine model of cachexia . Negative_regulation ALB TNF 2295699 127550 Therefore , selectively *inhibits* the genetic expression of [albumin] in this model before weight loss . Negative_regulation ALCAM S100B 23729438 2801827 Blocking [CD166/ALCAM] expression using small interfering RNA completely *inhibited* induced NF-?B activation in RAGE ( -/- ) , but not in WT cells . Negative_regulation ALDH2 ALDH3A1 16244377 1471204 In contrast , isosorbide-2,5-dinitrate ( ISDN , 1 microM ) inhibited activity ( 1.1 +/- 0.4 % of control ) but did not *inhibit* [ALDH2] activity even up to 50 microM ISDN . Negative_regulation ALDH2 CRYGEP 19922789 2203719 ( 4 ) also *inhibited* hepatic [ALDH2] activity in a time dependent manner without altering the protein level , suggesting ALDH2 inhibition through covalent modifications such as phosphorylation by JNK . Negative_regulation ALDH2 DDAH2 18289604 1878533 Exogenous ADMA significantly enhanced ROS production/MDA concentration and inhibited ALDH-2 activity , and overexpression of could significantly *suppress* GTN induced oxidative stress and inhibition of [ALDH-2] activity , which is also attenuated by L-arginine . Negative_regulation ALDH2 GYS1 22524197 2595804 In vitro data revealed that the [ALDH2] activator Alda-1 and kinase-3ß *inhibition* protected against high glucose induced mitochondrial and mechanical anomalies , the effect of which was cancelled by mitochondrial uncoupling . Negative_regulation ALDH2 GYS2 22524197 2595805 In vitro data revealed that the [ALDH2] activator Alda-1 and kinase-3ß *inhibition* protected against high glucose induced mitochondrial and mechanical anomalies , the effect of which was cancelled by mitochondrial uncoupling . Negative_regulation ALDH2 PRKAA1 21130747 2372858 In this study , we have demonstrated that ALDH2 acts as a transcriptional repressor in *response* to activation , and MDA modifies ALDH2 and inhibits repressive activity of [ALDH2] in general transcription . Negative_regulation ALDH2 PRKAA2 21130747 2372859 In this study , we have demonstrated that ALDH2 acts as a transcriptional repressor in *response* to activation , and MDA modifies ALDH2 and inhibits repressive activity of [ALDH2] in general transcription . Negative_regulation ALDH2 PRKAB1 21130747 2372860 In this study , we have demonstrated that ALDH2 acts as a transcriptional repressor in *response* to activation , and MDA modifies ALDH2 and inhibits repressive activity of [ALDH2] in general transcription . Negative_regulation ALDH2 PRKAB2 21130747 2372861 In this study , we have demonstrated that ALDH2 acts as a transcriptional repressor in *response* to activation , and MDA modifies ALDH2 and inhibits repressive activity of [ALDH2] in general transcription . Negative_regulation ALDH2 PRKAG1 21130747 2372862 In this study , we have demonstrated that ALDH2 acts as a transcriptional repressor in *response* to activation , and MDA modifies ALDH2 and inhibits repressive activity of [ALDH2] in general transcription . Negative_regulation ALDH2 PRKAG2 21130747 2372863 In this study , we have demonstrated that ALDH2 acts as a transcriptional repressor in *response* to activation , and MDA modifies ALDH2 and inhibits repressive activity of [ALDH2] in general transcription . Negative_regulation ALDH3A1 ALDH2 16244377 1471205 In contrast , isosorbide-2,5-dinitrate ( ISDN , 1 microM ) inhibited [ALDH3] activity ( 1.1 +/- 0.4 % of control ) but did not *inhibit* activity even up to 50 microM ISDN . Negative_regulation ALK EPHB2 21415216 2416594 *Role* of and STAT3-survivin signaling pathways in [ALK] inhibitor induced apoptosis in EML4-ALK positive lung cancer . Negative_regulation ALOX5 ADCY5 3132172 92745 Since the natural compound can selectively *inhibit* [5-lipoxygenase] and affect in vivo inflammation , it will be interesting to investigate the role of leukotrienes on inflammation and other physiological processes . Negative_regulation ALOX5 AGTR1 8355184 227446 RAPA to 50 microM did not *inhibit* in vitro human synovial phospholipase A2 or [5-lipoxygenase] and cyclo-oxygenase activity in the human blood leukocyte assay . Negative_regulation ALOX5 ALOX5AP 1469057 207085 To examine the *role* of in A23187 induced translocation of [5-LO] to a membrane fraction , we have studied the A23187 stimulated translocation of 5-LO in osteosarcoma cells expressing both 5-LO and FLAP , and in osteosarcoma cells expressing 5-LO only . Negative_regulation ALOX5 ALOX5AP 8245774 236935 These results demonstrate that the nuclear envelope is the intracellular site at which 5-LO and act to metabolize arachidonic acid , and that ionophore activation of neutrophils and monocytes *results* in the translocation of [5-LO] from a nonsedimentable location to the nuclear envelope . Negative_regulation ALOX5 APP 17998412 1882720 Absence of [5LO] did not *induce* any significant change in levels and processing , or Abeta catabolic pathways . Negative_regulation ALOX5 BCHE 23380204 2758973 The strongest [5-lipoxygenase (5-LOX)] , acetylcholinesterase (AChE) and *inhibition* activities were obtained for the ethanol extract ( IC50 values of 6.20 , 14.83 and 2.65mg/l , respectively ) and the best cytotoxic activity against MCF-7 cells was obtained for the methanol extract ( IC50=31mg/l ) . Negative_regulation ALOX5 CA2 12893830 1150176 Mutation of the Ca2+ binding sites within the C2-like domain of 5-LO resulted in strong reduction of [5-LO] activity by M-DSP and GPx-1 , also in the *presence* of . Negative_regulation ALOX5 CA2 2496978 109721 At higher arachidonate concentrations and in the *presence* of the glutathione effect was not observed but additional glutathione peroxidase also blocked this maximally stimulated [5-lipoxygenase] . Negative_regulation ALOX5 CAT 1994001 154233 Neither TMK-777 ( a [5-lipoxygenase] *inhibitor* ) ( 10 ( -7 ) M ) nor superoxide dismutase ( 100 U/ml ) plus ( 1,000 U/ml ) affected either contraction . Negative_regulation ALOX5 CDC123 21447614 2443717 *reduced* [5-LO] activity in cell-free assays ( purified human recombinant enzyme or leukocyte homogenates ) , with IC ( 50 ) values in the low nanomolar range ( 9-25 nM ) and a selectivity index of approximately 35 and 15 over p12-LO and 15-LO1 , respectively . Negative_regulation ALOX5 CDC123 21447614 2443731 Likewise , *inhibited* [5-LO] product formation in intact human polymorphonuclear leukocytes and monocytes ( IC ( 50 ) = 0.45-0.8 µM ) . Negative_regulation ALOX5 CDC16 21447614 2443718 *reduced* [5-LO] activity in cell-free assays ( purified human recombinant enzyme or leukocyte homogenates ) , with IC ( 50 ) values in the low nanomolar range ( 9-25 nM ) and a selectivity index of approximately 35 and 15 over p12-LO and 15-LO1 , respectively . Negative_regulation ALOX5 CDC16 21447614 2443732 Likewise , *inhibited* [5-LO] product formation in intact human polymorphonuclear leukocytes and monocytes ( IC ( 50 ) = 0.45-0.8 µM ) . Negative_regulation ALOX5 CDC20 21447614 2443719 *reduced* [5-LO] activity in cell-free assays ( purified human recombinant enzyme or leukocyte homogenates ) , with IC ( 50 ) values in the low nanomolar range ( 9-25 nM ) and a selectivity index of approximately 35 and 15 over p12-LO and 15-LO1 , respectively . Negative_regulation ALOX5 CDC20 21447614 2443733 Likewise , *inhibited* [5-LO] product formation in intact human polymorphonuclear leukocytes and monocytes ( IC ( 50 ) = 0.45-0.8 µM ) . Negative_regulation ALOX5 CDC23 21447614 2443720 *reduced* [5-LO] activity in cell-free assays ( purified human recombinant enzyme or leukocyte homogenates ) , with IC ( 50 ) values in the low nanomolar range ( 9-25 nM ) and a selectivity index of approximately 35 and 15 over p12-LO and 15-LO1 , respectively . Negative_regulation ALOX5 CDC23 21447614 2443734 Likewise , *inhibited* [5-LO] product formation in intact human polymorphonuclear leukocytes and monocytes ( IC ( 50 ) = 0.45-0.8 µM ) . Negative_regulation ALOX5 CDC26 21447614 2443729 *reduced* [5-LO] activity in cell-free assays ( purified human recombinant enzyme or leukocyte homogenates ) , with IC ( 50 ) values in the low nanomolar range ( 9-25 nM ) and a selectivity index of approximately 35 and 15 over p12-LO and 15-LO1 , respectively . Negative_regulation ALOX5 CDC26 21447614 2443743 Likewise , *inhibited* [5-LO] product formation in intact human polymorphonuclear leukocytes and monocytes ( IC ( 50 ) = 0.45-0.8 µM ) . Negative_regulation ALOX5 CDC27 21447614 2443721 *reduced* [5-LO] activity in cell-free assays ( purified human recombinant enzyme or leukocyte homogenates ) , with IC ( 50 ) values in the low nanomolar range ( 9-25 nM ) and a selectivity index of approximately 35 and 15 over p12-LO and 15-LO1 , respectively . Negative_regulation ALOX5 CDC27 21447614 2443735 Likewise , *inhibited* [5-LO] product formation in intact human polymorphonuclear leukocytes and monocytes ( IC ( 50 ) = 0.45-0.8 µM ) . Negative_regulation ALOX5 CDC34 21447614 2443722 *reduced* [5-LO] activity in cell-free assays ( purified human recombinant enzyme or leukocyte homogenates ) , with IC ( 50 ) values in the low nanomolar range ( 9-25 nM ) and a selectivity index of approximately 35 and 15 over p12-LO and 15-LO1 , respectively . Negative_regulation ALOX5 CDC34 21447614 2443736 Likewise , *inhibited* [5-LO] product formation in intact human polymorphonuclear leukocytes and monocytes ( IC ( 50 ) = 0.45-0.8 µM ) . Negative_regulation ALOX5 CDC37 21447614 2443723 *reduced* [5-LO] activity in cell-free assays ( purified human recombinant enzyme or leukocyte homogenates ) , with IC ( 50 ) values in the low nanomolar range ( 9-25 nM ) and a selectivity index of approximately 35 and 15 over p12-LO and 15-LO1 , respectively . Negative_regulation ALOX5 CDC37 21447614 2443737 Likewise , *inhibited* [5-LO] product formation in intact human polymorphonuclear leukocytes and monocytes ( IC ( 50 ) = 0.45-0.8 µM ) . Negative_regulation ALOX5 CDC40 21447614 2443724 *reduced* [5-LO] activity in cell-free assays ( purified human recombinant enzyme or leukocyte homogenates ) , with IC ( 50 ) values in the low nanomolar range ( 9-25 nM ) and a selectivity index of approximately 35 and 15 over p12-LO and 15-LO1 , respectively . Negative_regulation ALOX5 CDC40 21447614 2443738 Likewise , *inhibited* [5-LO] product formation in intact human polymorphonuclear leukocytes and monocytes ( IC ( 50 ) = 0.45-0.8 µM ) . Negative_regulation ALOX5 CDC42 21447614 2443725 *reduced* [5-LO] activity in cell-free assays ( purified human recombinant enzyme or leukocyte homogenates ) , with IC ( 50 ) values in the low nanomolar range ( 9-25 nM ) and a selectivity index of approximately 35 and 15 over p12-LO and 15-LO1 , respectively . Negative_regulation ALOX5 CDC42 21447614 2443739 Likewise , *inhibited* [5-LO] product formation in intact human polymorphonuclear leukocytes and monocytes ( IC ( 50 ) = 0.45-0.8 µM ) . Negative_regulation ALOX5 CDC45 21447614 2443726 *reduced* [5-LO] activity in cell-free assays ( purified human recombinant enzyme or leukocyte homogenates ) , with IC ( 50 ) values in the low nanomolar range ( 9-25 nM ) and a selectivity index of approximately 35 and 15 over p12-LO and 15-LO1 , respectively . Negative_regulation ALOX5 CDC45 21447614 2443740 Likewise , *inhibited* [5-LO] product formation in intact human polymorphonuclear leukocytes and monocytes ( IC ( 50 ) = 0.45-0.8 µM ) . Negative_regulation ALOX5 CDC6 21447614 2443727 *reduced* [5-LO] activity in cell-free assays ( purified human recombinant enzyme or leukocyte homogenates ) , with IC ( 50 ) values in the low nanomolar range ( 9-25 nM ) and a selectivity index of approximately 35 and 15 over p12-LO and 15-LO1 , respectively . Negative_regulation ALOX5 CDC6 21447614 2443741 Likewise , *inhibited* [5-LO] product formation in intact human polymorphonuclear leukocytes and monocytes ( IC ( 50 ) = 0.45-0.8 µM ) . Negative_regulation ALOX5 CDC7 21447614 2443728 *reduced* [5-LO] activity in cell-free assays ( purified human recombinant enzyme or leukocyte homogenates ) , with IC ( 50 ) values in the low nanomolar range ( 9-25 nM ) and a selectivity index of approximately 35 and 15 over p12-LO and 15-LO1 , respectively . Negative_regulation ALOX5 CDC7 21447614 2443742 Likewise , *inhibited* [5-LO] product formation in intact human polymorphonuclear leukocytes and monocytes ( IC ( 50 ) = 0.45-0.8 µM ) . Negative_regulation ALOX5 CDC73 21447614 2443716 *reduced* [5-LO] activity in cell-free assays ( purified human recombinant enzyme or leukocyte homogenates ) , with IC ( 50 ) values in the low nanomolar range ( 9-25 nM ) and a selectivity index of approximately 35 and 15 over p12-LO and 15-LO1 , respectively . Negative_regulation ALOX5 CDC73 21447614 2443730 Likewise , *inhibited* [5-LO] product formation in intact human polymorphonuclear leukocytes and monocytes ( IC ( 50 ) = 0.45-0.8 µM ) . Negative_regulation ALOX5 CDT1 2167696 140202 The possible utility of 654 , a potent [5-lipoxygenase] *inhibitor* , for treating human inflammatory skin disease was investigated in murine skin treated with 1.0 mg arachidonic acid ( AA ) . Negative_regulation ALOX5 CPOX 14752172 1205537 Licofelone , a competitive *inhibitor* of [5-lipoxygenase] , and COX-2 , is currently in clinical development for the treatment of osteoarthritis ( OA ) . Negative_regulation ALOX5 CPOX 17887937 1797457 A mixed extract containing two naturally occurring flavonoids , baicalin from Scutellaria baicalensis and catechin from Acacia catechu , was tested for and [5-lipoxygenase (5-LOX)] *inhibition* via enzyme , cellular , and in vivo models . Negative_regulation ALOX5 CPOX 18281656 1872428 We performed a randomized phase II trial to test the hypothesis that *inhibitors* of two eicosanoid pathways ( cyclooxygenase-2 <[COX-2> ] , celecoxib and [5-lipoxygenase] [ 5-LOX ] , zileuton ) added to chemotherapy would improve outcome in advanced non-small-cell lung cancer ( NSCLC ) . Negative_regulation ALOX5 CPOX 24295787 2894000 Novel di-tertiary-butyl phenylhydrazones as dual [cyclooxygenase-2/5-lipoxygenase] inhibitors : synthesis , *inhibition* , molecular modeling , and insights into their cytotoxicities . Negative_regulation ALOX5 CPP 8859938 388499 Similarly , pretreatment of isolated rabbit heart with defibrotide ( 200 mu g/ml ) , a polydeoxyribonucleotide derivative known to inhibit PMNL activation and enhance PGI ( 2 ) production by heart endothelial cells , produced significant protection against the increase in and almost complete *inhibition* of [5-LO] product synthesis . Negative_regulation ALOX5 CTLA4 17175250 1662396 This study examined the combinatory effect on graft survival of neonatal pig pancreatic cell clusters ( NPCC ) with nordihydroguaiaretic acid ( NDGA ) , a [5-lipoxygenase] *inhibitor* , with systemic CTLA4Ig expression , with local and with interleukin-1 (IL-1) receptor antagonist ( IL-1ra ) expression using a pig to mouse model . Negative_regulation ALOX5 CYSLTR1 10765473 580080 Two strategies for modulating the actions of the leukotrienes are currently undergoing clinical evaluation : antagonism and [5-lipoxygenase (5-LO)] *inhibition* . Negative_regulation ALOX5 CYSLTR2 10765473 580081 Two strategies for modulating the actions of the leukotrienes are currently undergoing clinical evaluation : antagonism and [5-lipoxygenase (5-LO)] *inhibition* . Negative_regulation ALOX5 FOXA2 23822876 2870689 expression *inhibited* 15-lipoxygenase ( Alox15 ) and increased [Alox5] transcription , each encoding key lipoxygenases associated with asthma . Negative_regulation ALOX5 GPX1 2496978 109723 At higher arachidonate concentrations and in the presence of Ca2+ the glutathione effect was not observed but additional also *blocked* this maximally stimulated [5-lipoxygenase] . Negative_regulation ALOX5 GPX1 9687587 522410 Nonredox [5-lipoxygenase] inhibitors *require* for efficient inhibition of 5-lipoxygenase activity . Negative_regulation ALOX5 GPX2 2496978 109724 At higher arachidonate concentrations and in the presence of Ca2+ the glutathione effect was not observed but additional also *blocked* this maximally stimulated [5-lipoxygenase] . Negative_regulation ALOX5 GPX2 9687587 522411 Nonredox [5-lipoxygenase] inhibitors *require* for efficient inhibition of 5-lipoxygenase activity . Negative_regulation ALOX5 GPX3 2496978 109725 At higher arachidonate concentrations and in the presence of Ca2+ the glutathione effect was not observed but additional also *blocked* this maximally stimulated [5-lipoxygenase] . Negative_regulation ALOX5 GPX3 9687587 522412 Nonredox [5-lipoxygenase] inhibitors *require* for efficient inhibition of 5-lipoxygenase activity . Negative_regulation ALOX5 GPX4 2496978 109726 At higher arachidonate concentrations and in the presence of Ca2+ the glutathione effect was not observed but additional also *blocked* this maximally stimulated [5-lipoxygenase] . Negative_regulation ALOX5 GPX4 9687587 522413 Nonredox [5-lipoxygenase] inhibitors *require* for efficient inhibition of 5-lipoxygenase activity . Negative_regulation ALOX5 GPX5 2496978 109727 At higher arachidonate concentrations and in the presence of Ca2+ the glutathione effect was not observed but additional also *blocked* this maximally stimulated [5-lipoxygenase] . Negative_regulation ALOX5 GPX5 9687587 522414 Nonredox [5-lipoxygenase] inhibitors *require* for efficient inhibition of 5-lipoxygenase activity . Negative_regulation ALOX5 GPX6 2496978 109728 At higher arachidonate concentrations and in the presence of Ca2+ the glutathione effect was not observed but additional also *blocked* this maximally stimulated [5-lipoxygenase] . Negative_regulation ALOX5 GPX6 9687587 522415 Nonredox [5-lipoxygenase] inhibitors *require* for efficient inhibition of 5-lipoxygenase activity . Negative_regulation ALOX5 GPX7 2496978 109729 At higher arachidonate concentrations and in the presence of Ca2+ the glutathione effect was not observed but additional also *blocked* this maximally stimulated [5-lipoxygenase] . Negative_regulation ALOX5 GPX7 9687587 522416 Nonredox [5-lipoxygenase] inhibitors *require* for efficient inhibition of 5-lipoxygenase activity . Negative_regulation ALOX5 GPX8 2496978 109722 At higher arachidonate concentrations and in the presence of Ca2+ the glutathione effect was not observed but additional also *blocked* this maximally stimulated [5-lipoxygenase] . Negative_regulation ALOX5 GPX8 9687587 522409 Nonredox [5-lipoxygenase] inhibitors *require* for efficient inhibition of 5-lipoxygenase activity . Negative_regulation ALOX5 HDAC1 12817474 1103607 Trichostatin A and structurally related inhibitors *induce* [5-lipoxygenase] promoter activity . Negative_regulation ALOX5 HDAC10 12817474 1103605 Trichostatin A and structurally related inhibitors *induce* [5-lipoxygenase] promoter activity . Negative_regulation ALOX5 HDAC11 12817474 1103606 Trichostatin A and structurally related inhibitors *induce* [5-lipoxygenase] promoter activity . Negative_regulation ALOX5 HDAC2 12817474 1103608 Trichostatin A and structurally related inhibitors *induce* [5-lipoxygenase] promoter activity . Negative_regulation ALOX5 HDAC3 12817474 1103609 Trichostatin A and structurally related inhibitors *induce* [5-lipoxygenase] promoter activity . Negative_regulation ALOX5 HDAC4 12817474 1103600 Trichostatin A and structurally related inhibitors *induce* [5-lipoxygenase] promoter activity . Negative_regulation ALOX5 HDAC5 12817474 1103604 Trichostatin A and structurally related inhibitors *induce* [5-lipoxygenase] promoter activity . Negative_regulation ALOX5 HDAC6 12817474 1103601 Trichostatin A and structurally related inhibitors *induce* [5-lipoxygenase] promoter activity . Negative_regulation ALOX5 HDAC7 12817474 1103603 Trichostatin A and structurally related inhibitors *induce* [5-lipoxygenase] promoter activity . Negative_regulation ALOX5 HDAC8 12817474 1103599 Trichostatin A and structurally related inhibitors *induce* [5-lipoxygenase] promoter activity . Negative_regulation ALOX5 HDAC9 12817474 1103602 Trichostatin A and structurally related inhibitors *induce* [5-lipoxygenase] promoter activity . Negative_regulation ALOX5 HLA-B 9784426 540797 LPS induced IL-6 release was partially inhibited by , a [5-lipoxygenase] *inhibitor* . Negative_regulation ALOX5 IDO1 8460711 215714 In 12 other preparations , fMLP activated HL-60 cells were pretreated with either 10 microM or 100 microM A63162 , a [5-lipoxygenase] *inhibitor* . Negative_regulation ALOX5 IL10 22926034 2697599 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL11 22926034 2697600 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL13 22926034 2697601 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL15 22926034 2697602 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL16 22926034 2697603 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL18 22926034 2697604 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL19 22926034 2697605 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL1RN 17175250 1662397 This study examined the combinatory effect on graft survival of neonatal pig pancreatic cell clusters ( NPCC ) with nordihydroguaiaretic acid ( NDGA ) , a [5-lipoxygenase] *inhibitor* , with systemic CTLA4Ig expression , with local CTLA4Ig and with ( IL-1ra ) expression using a pig to mouse model . Negative_regulation ALOX5 IL2 22926034 2697606 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL20 22926034 2697607 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL21 22926034 2697608 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL22 22926034 2697591 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL24 22926034 2697589 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL25 22926034 2697590 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL26 22926034 2697595 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL27 22926034 2697596 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL3 22926034 2697609 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL31 22926034 2697597 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL32 22926034 2697594 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL33 22926034 2697593 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL34 22926034 2697598 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL37 22926034 2697592 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL4 22926034 2697610 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL5 22926034 2697611 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL6 22926034 2697612 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL7 22926034 2697613 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL8 22926034 2697614 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 IL9 22926034 2697615 We then present different approaches that tackle inflammation , including inhibition of [5-lipoxygenase] , blockade of P-selectin , use of a viral derived serpin , and *inhibition* . Negative_regulation ALOX5 LOX 24295787 2894001 Novel di-tertiary-butyl phenylhydrazones as dual [cyclooxygenase-2/5-lipoxygenase] inhibitors : synthesis , *inhibition* , molecular modeling , and insights into their cytotoxicities . Negative_regulation ALOX5 LTB 18369577 1888214 RBx 7796 inhibited [5-lipoxygenase] enzyme and *inhibited* release of from neutrophils . Negative_regulation ALOX5 LTB 20207999 2229881 In addition , ( 4 ) , but not LTD ( 4 ) , *reduced* FFA uptake in primary adipocytes , whereas [5-LO] inhibition suppressed isoproterenol induced adipose tissue lipolysis . Negative_regulation ALOX5 LTB 2126672 146847 In parallel laboratory assays , Tenidap was found to exhibit a significant in vitro dose dependent *inhibition* of ionophore stimulated neutrophil production of the [5-lipoxygenase] product : [ 3H ] . Negative_regulation ALOX5 LTC4S 12767051 1094252 The addition of methylprednisolone ( MP ) inhibited generation of cysLTs from the cells with A23187-stimulation and also did activity , but did not *inhibit* [5-lipoxygenase (5-LOX)] . Negative_regulation ALOX5 LTC4S 9113110 425989 LTC4-S inhibition by FLAP inhibitors is in agreement with the significant homology reported for expression cloned LTC4-S with FLAP , Furthermore , functional homology of the binding sites for inhibitors on LTC4-S and FLAP is suggested by the conservation of the relative potencies of MK-886 and BAY-X1005 vs FLAP dependent [5-lipoxygenase] activity and *inhibition* : MK-886 was 19.3-fold more potent than BAY-X1005 as FLAP inhibitor and 19.6-fold more potent than BAY-X1005 as LTC4-S inhibitor . Negative_regulation ALOX5 MAP2K1 11091139 754762 In order to elucidate the *role* of ( MEK-1/2 ) in [5-lipoxygenase (5-LO)] activation we studied the N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -induced 5-LO translocation in human blood neutrophils ( PMNs ) . Negative_regulation ALOX5 MAP2K2 11091139 754763 In order to elucidate the *role* of ( MEK-1/2 ) in [5-lipoxygenase (5-LO)] activation we studied the N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -induced 5-LO translocation in human blood neutrophils ( PMNs ) . Negative_regulation ALOX5 MAP2K3 11091139 754764 In order to elucidate the *role* of ( MEK-1/2 ) in [5-lipoxygenase (5-LO)] activation we studied the N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -induced 5-LO translocation in human blood neutrophils ( PMNs ) . Negative_regulation ALOX5 MAP2K4 11091139 754765 In order to elucidate the *role* of ( MEK-1/2 ) in [5-lipoxygenase (5-LO)] activation we studied the N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -induced 5-LO translocation in human blood neutrophils ( PMNs ) . Negative_regulation ALOX5 MAP2K5 11091139 754766 In order to elucidate the *role* of ( MEK-1/2 ) in [5-lipoxygenase (5-LO)] activation we studied the N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -induced 5-LO translocation in human blood neutrophils ( PMNs ) . Negative_regulation ALOX5 MAP2K6 11091139 754767 In order to elucidate the *role* of ( MEK-1/2 ) in [5-lipoxygenase (5-LO)] activation we studied the N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -induced 5-LO translocation in human blood neutrophils ( PMNs ) . Negative_regulation ALOX5 MAP2K7 11091139 754768 In order to elucidate the *role* of ( MEK-1/2 ) in [5-lipoxygenase (5-LO)] activation we studied the N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -induced 5-LO translocation in human blood neutrophils ( PMNs ) . Negative_regulation ALOX5 MBD1 19781662 2183766 Furthermore , we found that overexpression *repressed* [5-LO] promoter activity when the CpG sites at the Sp1 binding site close to the transcriptional start site ( GC4 ) were methylated . Negative_regulation ALOX5 MCOLN1 9072050 343723 Human recombinant [5-lipoxygenase] was also *inhibited* by in the same concentration range ( IC50 16 mM ) . Negative_regulation ALOX5 MEPE 17766677 1822813 Separate administration ( 4-chlorophenyl ) -3- ( trifluoromethyl ) -1H-pyrazol-1-yl ] benzenesulfonamide ( SC-236 ) , a selective COX-2 inhibitor , and CJ-13,610 , a [5-LO] *inhibitor* , to carbon tetrachloride treated mice significantly reduced fibrosis as revealed by the analysis of Sirius Red stained liver sections without affecting necroinflammation . Negative_regulation ALOX5 PBRM1 7814884 292805 The increase in leukocyte flux associated with CMP 48/80 was blocked by diphenhydramine ( H1-receptor antagonist ) and an anti-P-selectin Ab ( ) , but not by the [5-lipoxygenase] *inhibitor* , MK 886 . Negative_regulation ALOX5 PLA2G1B 7562506 324311 However , SK & F 45905 inhibited 85-kDa activity ( IC50 = 3 microM ) , and both compounds *inhibited* [5-lipoxygenase] activity ( IC50 values of 2-4 microM ) . Negative_regulation ALOX5 PLA2G4A 18665843 1979415 In vitro responses of asthma ( N=26 ) and healthy ( N=11 ) subject PBMC samples to allergen stimulation in the presence and absence of inhibition or [5-lipoxygenase] *inhibition* were compared at the gene expression level using oligonucleotide arrays and at the protein level using ELISA . Negative_regulation ALOX5 PLA2G4A 9654399 516126 Terfenadine inhibited the synthesis of LTC4 to 67.2 % at a concentration of 5 microg/ml. LT synthesis was directly suppressed by inhibition of [5-lipoxygenase (5-LO)] through calcium ion independent mechanisms , and was also possibly *suppressed* by inhibition of and 5-LO by blocking the influx of intracellular calcium ion that was initiated by IgE related stimulation . Negative_regulation ALOX5 PRKG1 18474265 1927467 activation *resulted* in phosphorylation of [5-LO] . Negative_regulation ALOX5 PSMD2 11082424 750332 did not directly *inhibit* the enzymatic activity of [5-LO] , but prevented its translocation to the nuclear membrane without affecting the requisite calcium signal . Negative_regulation ALOX5 PTGES 24315851 2904893 The n-hexane extract of M. pinnata efficiently suppressed [5-LO] activity in stimulated human neutrophils ( IC50 =8.7µg/ml ) and potently *inhibited* isolated human recombinant 5-LO ( IC50 =0.48µg/ml ) and ( IC50 =1.0µg/ml ) . Negative_regulation ALOX5 PTGS2 14752172 1205538 Licofelone , a competitive *inhibitor* of [5-lipoxygenase] , cyclooxygenase (COX)-1 and , is currently in clinical development for the treatment of osteoarthritis ( OA ) . Negative_regulation ALOX5 SLAMF7 7787309 313040 , a soybean lipoxygenase ( SBL ) and human [5-lipoxygenase (5-LO)] *inhibitor* , was isolated from Streptomyces sp. USF-19 strain . Negative_regulation ALOX5 SNORA66 3107853 73491 Six rats received a [5-lipoxygenase] *inhibitor* ( 1-naphthalenol,2,3,diethyl-4-methoxy-acetate ) ( ) ( 20 mg/kg ) . Negative_regulation ALOX5 SNORD60 6097546 44050 Enzyme release from LTB4 treated cells was suppressed with the phospholipase inhibitor , 4-bromophenacyl bromide ( 4-BPB ) , the cyclooxygenase/lipoxygenase inhibitor , ETYA , and the [5-lipoxygenase] *inhibitor* , , 257 . Negative_regulation ALOX5 SOD1 1994001 154230 Neither TMK-777 ( a [5-lipoxygenase] *inhibitor* ) ( 10 ( -7 ) M ) nor ( 100 U/ml ) plus catalase ( 1,000 U/ml ) affected either contraction . Negative_regulation ALOX5 SOD2 1994001 154231 Neither TMK-777 ( a [5-lipoxygenase] *inhibitor* ) ( 10 ( -7 ) M ) nor ( 100 U/ml ) plus catalase ( 1,000 U/ml ) affected either contraction . Negative_regulation ALOX5 SOD3 1994001 154232 Neither TMK-777 ( a [5-lipoxygenase] *inhibitor* ) ( 10 ( -7 ) M ) nor ( 100 U/ml ) plus catalase ( 1,000 U/ml ) affected either contraction . Negative_regulation ALOX5 SP1 20554538 2327599 Moreover , the *role* of and NF-?B in HNE induced [5-LO] expression was confirmed by siRNA knockdown of Sp1 and NF-?B . Negative_regulation ALOX5 USF1 7787309 313038 , a soybean lipoxygenase ( SBL ) and human [5-lipoxygenase (5-LO)] *inhibitor* , was isolated from Streptomyces sp. USF-19 strain . Negative_regulation ALOX5 USF2 7787309 313039 , a soybean lipoxygenase ( SBL ) and human [5-lipoxygenase (5-LO)] *inhibitor* , was isolated from Streptomyces sp. USF-19 strain . Negative_regulation ALOX5 VHL 17616938 1769500 The loss of expression *led* to high basal [5-LO] and VEGF expression , which were markedly reduced by transfection with 5-LO small interfering RNA ( siRNA ) . Negative_regulation ALOX5 WAS 15073046 1279325 Curcumin and potently *inhibited* the activity of human recombinant [5-LOX] , showing estimated IC ( 50 ) values of 0.7 and 3 micro M , respectively . Negative_regulation ALOX5AP PLAT 17330201 1707348 *Role* of recombinant in free [flap] salvage . Negative_regulation AMH TNF 12917325 1130515 *inhibited* [MIS] expression in testis organ cultures , and TNF-alpha ( -/- ) testes showed high and prolonged MIS expression . Negative_regulation AMOTL1 TNF 23793505 2828617 The *role* of and interferon-? in regulating [angiomotin-like protein 1] expression in lung microvascular endothelial cells . Negative_regulation ANAPC1 TFPI2 9405394 469798 The direct interaction of PP5 with CDC16 and CDC27 , as well as its overlapping spindle localization in mitosis , suggests that may be *involved* in the regulation of the activity of the [anaphase promoting complex] . Negative_regulation ANAPC2 TFPI2 9405394 469799 The direct interaction of PP5 with CDC16 and CDC27 , as well as its overlapping spindle localization in mitosis , suggests that may be *involved* in the regulation of the activity of the [anaphase promoting complex] . Negative_regulation ANAPC4 TFPI2 9405394 469800 The direct interaction of PP5 with CDC16 and CDC27 , as well as its overlapping spindle localization in mitosis , suggests that may be *involved* in the regulation of the activity of the [anaphase promoting complex] . Negative_regulation ANAPC5 TFPI2 9405394 469793 The direct interaction of PP5 with CDC16 and CDC27 , as well as its overlapping spindle localization in mitosis , suggests that may be *involved* in the regulation of the activity of the [anaphase promoting complex] . Negative_regulation ANAPC7 TFPI2 9405394 469797 The direct interaction of PP5 with CDC16 and CDC27 , as well as its overlapping spindle localization in mitosis , suggests that may be *involved* in the regulation of the activity of the [anaphase promoting complex] . Negative_regulation ANG CTGF 17318787 1664878 We have evaluated the *role* of in vascular and renal damage associated with hypertension and possible interactions with [angiotensin II (Ang II)] . Negative_regulation ANG PLAU 21389187 2416200 From the angiogenesis antibody array analysis , we observed that the simultaneous downregulation of uPAR and *resulted* in the downregulation of [angiogenin] and overexpression of RANTES . Negative_regulation ANGPT1 ACE 1317125 187858 inhibition *increased* renal and plasma [ANG I] levels 2.8- and 12-fold , respectively , and decreased renal and plasma ANG II levels 75-78 % . Negative_regulation ANGPT1 ACE 2147739 145503 Systemic blood pressure did not change throughout the trial , indicating that no major systemic effects were present during [ANG-I] infusion or concomitant *inhibition* . Negative_regulation ANGPT1 ACE 2831145 84978 This study revealed the presence of high ACE activity in monoamine regions of dog brainstem and spinal cord , and showed that the metabolite Ang- ( 1-7 ) is the major product generated from [Ang I] in the *presence* and absence of inhibition . Negative_regulation ANGPT1 ACE 7658973 290934 A study was performed on renin synthesis in order to evaluate changes that occur in renal cells during chronic *inhibition* of [Ang I] in mice . Negative_regulation ANGPT1 ACE2 15467007 1359219 ACE2 is expressed in the kidney , but its precise intrarenal localization is unclear , and the *role* of intrarenal in the production of [ANG 1-7] is unknown . Negative_regulation ANGPT1 AMELX 19546406 2110338 Safety , pharmacokinetics , and antitumor activity of 386 , a selective [angiopoietin] *inhibitor* , in adult patients with advanced solid tumors . Negative_regulation ANGPT1 ANGPT1 15381091 1298591 Functional inhibition of secreted [angiopoietin] : a novel *role* for in coronary vessel patterning . Negative_regulation ANGPT1 ANGPT2 11861279 917096 Thrombin induced secreted *inhibited* the binding of recombinant ( 35 ) [S-Ang-1] to its Tie-2-Fc receptor , demonstrating functionality . Negative_regulation ANGPT1 ANGPT2 11967990 938068 Hypoxia induced expression of NERF2 and Tie2 was blocked by , a competitive *inhibitor* of [angiopoietin-1] , and by recombinant soluble extracellular domain of Tie2 but not by VEGF neutralizing antibodies . Negative_regulation ANGPT1 ANGPT2 19838115 2184159 Early experiments showed that Ang1 stabilizes newly formed vessels and reduces vascular permeability , with *blocking* [Ang1] activation of the Tie2 receptor . Negative_regulation ANGPT1 ANGPT2 20937592 2332760 In no case was Ang1 inhibition shown to ( a ) confer superior activity to inhibition or dual [Ang1/2] *inhibition* or ( b ) antagonize the efficacy of Ang2 inhibition . Negative_regulation ANGPT1 ANGPT2 7994001 283035 Similarly , the 30-fold increase in plasma during ANG II infusion was not *followed* by an increase in ANG II excretion , but in fact by a decrease in urinary [ANG I] and ANG II . Negative_regulation ANGPT1 ANGPT2 8263802 239253 The dose-response curves of contractions obtained with ANG I or as well as the dose dependent *inhibition* of [ANG I-induced] responses in the presence of CGS 16617 were similar for carotids taken from both WKY and SHR. Responses to ANG I were restored as early as 5 min after incubation solutions containing inhibitory concentrations of CGS 16617 were removed . Negative_regulation ANGPT1 ANGPT2 9887046 584953 They also *inhibited* the increases in LV in both the infarct and infarct-free LV at 1 and 3 days post-MI with however no significant increase in LV [ANG I] . Negative_regulation ANGPT1 ANGPTL1 15342395 1291930 In addition , we have demonstrated that the binding of Ang-3 to the cell surface is required for the effective inhibition of Ang-3 on tumor metastasis and that inhibits endothelial cell proliferation and survival and *blocks* [Ang-1-] and vascular endothelial growth factor induced activation of extracellular signal regulated kinase 1/2 and Akt kinases , which likely underlie the Ang-3 mediated inhibition on tumor angiogenesis and metastasis . Negative_regulation ANGPT1 ANGPTL1 8396341 230292 ANG I ( 10 ( -9 ) M ) and ( 10 ( -10 ) M ) also stimulated the Na(+)-HCO3- cotransporter , and captopril ( 10 ( -4 ) M ) *attenuated* the [ANG I] stimulation by 68 +/- 3.5 % ( P < 0.01 ) but not that of ANG II and III . Negative_regulation ANGPT1 APLN 24363305 2911370 In WT mice , overexpression of *increased* Sirt3 , VEGF/VEGFR2 , and [angiopoietin-1 (Ang-1)/Tie-2] expression in the heart . Negative_regulation ANGPT1 APLN 24363305 2911375 Overexpression of *increased* Sirt3 , VEGF/VEGFR2 , and [Ang-1/Tie-2] expression together with improved vascular density in db/db mice . Negative_regulation ANGPT1 CAV1 16690881 1570021 Prolonged AAV mediated [Ang1] transgene expression also *induced* SMC activation , whereas AAV-Ang2 lacked the SMC activating effects and decreased . Negative_regulation ANGPT1 IL1B 15126358 1244841 Both and tumor necrosis factor-alpha *caused* marked down-regulation of [Ang-1] mRNA levels at 4 h with a further decrease observed at 24 h. Using signaling inhibitors , we identified the P38 pathway as the pathway that mediates IL-1beta down-regulation of Ang-1 . Negative_regulation ANGPT1 IL6 22596210 2643463 not only enhances VEGF expression but also *inhibits* [Ang-1] signalling by directly down regulating Ang-1 expression and up-regulating Ang-2 , an antagonist of Ang-1 . Negative_regulation ANGPT1 KLF2 19106103 2036470 Here , we investigated the mechanism of how Ang1/Tie2 signal induces KLF2 expression to clarify the *role* of in [Ang1/Tie2] signal mediated vascular quiescence . Negative_regulation ANGPT1 MAPK1 22508858 2613272 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Negative_regulation ANGPT1 MAPK10 22508858 2613273 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Negative_regulation ANGPT1 MAPK11 22508858 2613274 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Negative_regulation ANGPT1 MAPK12 22508858 2613275 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Negative_regulation ANGPT1 MAPK13 22508858 2613276 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Negative_regulation ANGPT1 MAPK14 22508858 2613277 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Negative_regulation ANGPT1 MAPK15 22508858 2613271 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Negative_regulation ANGPT1 MAPK3 22508858 2613278 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Negative_regulation ANGPT1 MAPK4 22508858 2613279 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Negative_regulation ANGPT1 MAPK6 22508858 2613280 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Negative_regulation ANGPT1 MAPK7 22508858 2613281 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Negative_regulation ANGPT1 MAPK8 22508858 2613282 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Negative_regulation ANGPT1 MAPK9 22508858 2613283 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Negative_regulation ANGPT1 PDGFD 15994946 1429933 Overexpression of *led* to increased expression of [angiopoietin-1] and matrix metalloproteinase-9 in tumor tissues . Negative_regulation ANGPT1 PRD 24347761 2880956 In the investigation of pancreatic angiogenic factors , *inhibited* the decreased expression of VEGF and [Ang-1] , and reversed the reduction of VEGFR2 and Tie2 phosphorylation in T2DM rats ; Negative_regulation ANGPT1 PRDX2 21297075 2425804 dose-dependently *suppressed* vascular endothelial growth factor , endothelial nitric oxide synthase , and [angiopoietin-1] expression in cultured myocardial endothelial cells , which effects were mimicked by selective gene silencing of several class I and II HDACs . Negative_regulation ANGPT1 PTH 17039426 1631029 An adenylyl cyclase activator , forskolin , was shown to *induce* [Ang-1] mRNA expression , whereas the protein kinase A inhibitor , H-89 , blocked the ( 1-34 ) -mediated expression of Ang-1 mRNA . Negative_regulation ANGPT1 REN 21045736 2370731 inhibition *increased* [angiopoietin-1] in SHR and reduced angiopoietin-2 in both WKY and SHR blood pressure independently . Negative_regulation ANGPT1 SLC33A1 8315514 222831 ASSOCIATED CHANGES IN ANG I AND ANG II : blockade by losartan is *followed* by rises in plasma [Ang I] and Ang II ; Negative_regulation ANGPT1 SMC2 16690881 1570019 Prolonged AAV mediated [Ang1] transgene expression also *induced* SMC activation , whereas AAV-Ang2 lacked the activating effects and decreased CAV . Negative_regulation ANGPT1 SMC3 16690881 1570024 Prolonged AAV mediated [Ang1] transgene expression also *induced* SMC activation , whereas AAV-Ang2 lacked the activating effects and decreased CAV . Negative_regulation ANGPT1 SMC4 16690881 1570020 Prolonged AAV mediated [Ang1] transgene expression also *induced* SMC activation , whereas AAV-Ang2 lacked the activating effects and decreased CAV . Negative_regulation ANGPT1 SMC5 16690881 1570022 Prolonged AAV mediated [Ang1] transgene expression also *induced* SMC activation , whereas AAV-Ang2 lacked the activating effects and decreased CAV . Negative_regulation ANGPT1 SMC6 16690881 1570023 Prolonged AAV mediated [Ang1] transgene expression also *induced* SMC activation , whereas AAV-Ang2 lacked the activating effects and decreased CAV . Negative_regulation ANGPT1 TIE1 15381091 1298598 We show that Ang1cc can inhibit activation and can *inhibit* [Ang1] activity in vitro and in vivo . Negative_regulation ANGPT1 TIE1 17901375 1824155 sTie2 bound both [Ang1] and Ang2 and *inhibited* angiopoietin mediated phosphorylation and antiapoptosis . Negative_regulation ANGPT1 TIE1 19922791 2184707 Previous work has shown that [Ang1] binding and activation of Tie2 are *inhibited* by , a related receptor that complexes with Tie2 in cells . Negative_regulation ANGPT1 TIE1 20227369 2223726 To address the *role* of in [angiopoietin] mediated Tie2 signaling and determine the basis for the behavior of the individual angiopoietins , we used an in vivo FRET based proximity assay to monitor Tie1 and -2 localization and association . Negative_regulation ANGPT1 TIE1 20547659 2315733 significantly *inhibited* HUVEC cytoprotection and migration in response to Ang1 alone , or [Ang1] in combination with VEGF . Negative_regulation ANGPT1 TIE1 20547659 2315735 , a novel splice variant of the Tie1 receptor , *inhibits* [Ang1/VEGF] signalling , suggesting that Ang inhibition may be of therapeutic benefit in inflammatory arthritis . Negative_regulation ANGPT1 TIE1 22103492 2509483 This receptor interacts with the related protein Tie1 on the cell surface , and *inhibits* [Ang1] signalling through Tie2 . Negative_regulation ANGPT1 TIMP1 23663694 2784958 Enzyme linked immunosorbent assay ( ELISA ) was employed to measure levels of five serum proteins previously demonstrated to be up-regulated in papillary thyroid cancer (PTC) : [angiopoietin-1 (Ang-1)] , cytokeratin 19 (CK-19) , tissue *inhibitor* of metalloproteinase-1 ( ) , chitinase 3 like-1 ( YKL-40 ) , and galectin-3 (GAL-3) . Negative_regulation ANGPT1 TNF 15126358 1244840 Both IL-1beta and *caused* marked down-regulation of [Ang-1] mRNA levels at 4 h with a further decrease observed at 24 h. Using signaling inhibitors , we identified the P38 pathway as the pathway that mediates IL-1beta down-regulation of Ang-1 . Negative_regulation ANGPT1 TNIP2 12933576 1174015 Expression of truncated *prevented* the Tie2 activating ligand [angiopoietin-1] from inhibiting endothelial cell death . Negative_regulation ANGPT1 VEGFA 16814127 1580792 The increase of induced by ang II was suppressed by losartan , and the increase of [Ang1] induced by ang II was *inhibited* by PD123319 as detected by immunoblot . Negative_regulation ANGPT1 VEGFA 21704211 2447102 The results showed that NECA treatment triggered down-regulation of [Ang1] , *induced* expression , and stimulated neovascularization , highlighting the beneficial effect of NECA on the process of angiogenesis . Negative_regulation ANGPT1 VEGFA 22447000 2588498 In unstable lesions , compared with stable lesions , was 1.7-fold increased ( P=0.032 ) and [Ang-1] was 1.9-fold *reduced* ( P=0.029 ) . Negative_regulation ANGPT1 VEGFA 22596210 2643462 IL-6 not only enhances expression but also *inhibits* [Ang-1] signalling by directly down regulating Ang-1 expression and up-regulating Ang-2 , an antagonist of Ang-1 . Negative_regulation ANGPT2 ANGPT1 12628953 1067231 Ad . perfusion *reduced* [Ang2] expression in microcirculation , the numbers of graft infiltrating leukocytes , and the level of immunoactivation and interstitial fibrosis , as well as both the incidence and intensity of intimal lesions . Negative_regulation ANGPT2 ANGPT1 12811821 1102911 Expression of alpha-smooth muscle ( SM ) actin , apparent in the contractile phenotype , was decreased by FN. Expressions of matrix Gla and osteopontin , apparent in the synthetic phenotype , were increased by FN . [Ang II] measured by radioimmunoassay ( RIA ) was significantly increased in human VSMC by FN. Expression of mRNAs for Ang II-generating proteases cathepsin D , cathepsin G , ACE , and chymase was increased by FN. Expressions of cathepsin D and cathepsin G proteins were also *increased* by FN. activity , which was inhibited by an aspartyl protease inhibitor pepstatin A , was readily detected in the conditioned medium from human VSMC . Negative_regulation ANGPT2 ANGPT1 15381091 1298592 Functional inhibition of secreted [angiopoietin] : a novel *role* for in coronary vessel patterning . Negative_regulation ANGPT2 ANGPT1 16014048 1431819 At the early stage ( day 6 ) , glomerular expression of VEGF and receptors flk-1 and flt-1 as well as , and receptor Tie2 were increased , and glomerular monocyte infiltration and the expression of [angiopoietin-2 (Ang-2)] , a natural antagonist of Ang-1 , were *reduced* . Negative_regulation ANGPT2 ANGPT1 20937592 2332761 In no case was Ang1 inhibition shown to ( a ) confer superior activity to [Ang2] inhibition or dual *inhibition* or ( b ) antagonize the efficacy of Ang2 inhibition . Negative_regulation ANGPT2 ANGPT1 9887046 584954 They also *inhibited* the increases in LV [ANG II] in both the infarct and infarct-free LV at 1 and 3 days post-MI with however no significant increase in LV . Negative_regulation ANGPT2 ARSA 22306536 2565245 These observations suggest that *inhibits* [Ang II-induced] NADPH oxidase expression , NF-?B activation and AT1R transcription in cardiac fibroblasts , and fibroblast proliferation and collagen expression . Negative_regulation ANGPT2 EPHB2 11322781 807189 Antioxidants such as catalase or N-acetyl-cysteine decreased Ang II-activated phosphorylation and *inhibited* [Ang II-induced] beta-MyHC promoter activity . Negative_regulation ANGPT2 EPHB2 9886938 584886 ANG II-induced activations of Fyn , Raf-1 , and were augmented in cells pretreated with BAPTA-AM , but [ANG II-induced] expression of the dual-specificity phosphatase mitogen activated protein kinase phosphatase-1 was *blocked* by BAPTA-AM pretreatment . Negative_regulation ANGPT2 F2R 20180904 2272419 These results suggest a physiologic role for the low concentration of thrombin in maintaining the integrity of the EPCR containing vasculature through the dependent *inhibition* of [Ang2] and P-selectin release from Weibel-Palade bodies . Negative_regulation ANGPT2 FOXO1 17960565 1844739 Our results support a VEGF dependent induction of Ang-2 in low flow areas , and *dependent* downregulation of [Ang-2] in high flow areas . Negative_regulation ANGPT2 FOXO1 18006475 1851638 Moreover , as the AMPK dependent phosphorylation and degradation of *attenuates* [Ang-2] expression and protects against the pro-inflammatory actions of TNF-alpha , this kinase may be a useful target to prevent the progression of vascular diseases . Negative_regulation ANGPT2 FOXO1 20228261 2254439 Dominant negative Akt and constitutively active *blocked* the ability of IGF-1 to prevent [ANG II-mediated] upregulation of atrogin-1 and skeletal muscle wasting . Negative_regulation ANGPT2 HBEGF 11737589 885866 We studied the *roles* of and endothelial growth factor (EGF) receptor ( EGFR ) in [Ang II-induced] FN expression using mesangial cells . Negative_regulation ANGPT2 IL1B 17989112 1850954 In summary , these data indicate that *inhibited* [ANG II-mediated] type IV collagen production , via CTGF downregulation , and increased type IV collagen degradation , through MMP-9 upregulation . Negative_regulation ANGPT2 MAP2K6 18511912 1939531 Inhibiting Ang II type 1 (AT1) receptor , Ras , or *blocked* the [Ang II-induced] increase in smMLCK expression . Negative_regulation ANGPT2 RGS2 15914115 1412597 These results suggest that may be *involved* in short-term regulation of [Ang II-induced] Gi-mediated adenylyl cyclase signalling . Negative_regulation ANGPT2 RGS2 16627589 1583055 overexpression by retroviral infection in H295R cells *caused* a decrease in [Ang II-stimulated] aldosterone secretion but did not modify cortisol secretion . Negative_regulation ANGPT2 TNF 8768832 378764 *reduced* [ANG II-] and potassium induced aldosterone synthesis and CYP11B2 mRNA levels . Negative_regulation ANGPT4 ANGPT1 15381091 1298593 Functional inhibition of secreted [angiopoietin] : a novel *role* for in coronary vessel patterning . Negative_regulation ANKH IL1B 20133941 2227001 [Ank] expression and PP(i) transport were strongly *reduced* by , whereas Wnt-5a was the only Wnt protein increased . Negative_regulation ANKRD1 ADCY6 21127130 2390063 For example , both and AC6mut *reduced* phenylephrine induced cardiac myocyte hypertrophy and apoptosis ( p < 0.001 ) , expression of [cardiac ankyrin repeat protein] ( p < 0.01 ) , and phospholamban ( p < 0.05 ) . Negative_regulation ANKRD1 DDIT3 15826945 1417731 Furthermore , transcriptionally *down-regulated* the expression of the [cardiac ankyrin repeat protein] gene ( CARP ) , which is a nuclear transcriptional co-factor that negatively regulates the expression of the cardiac gene . Negative_regulation ANO1 ANO10 20056604 2211918 In contrast ANO9 and suppressed baseline Cl ( - ) conductance and coexpression of ANO9 with ANO1 *inhibited* [ANO1] activity . Negative_regulation ANO1 ANO9 20056604 2211917 In contrast and ANO10 suppressed baseline Cl ( - ) conductance and coexpression of ANO9 with ANO1 *inhibited* [ANO1] activity . Negative_regulation ANO1 CFTR 22178883 2518397 [TMEM16A-currents] were *attenuated* by additional expression of , and were completely abrogated when additionally expressed CFTR was activated by IBMX and forskolin . Negative_regulation ANO1 TFP1 24420770 2907229 Although [Ano1] is *blocked* by the CaM inhibitor , we propose that TFP inhibits the channel in a CaM independent manner because TFP does not inhibit Ano1 when applied to the cytoplasmic side of excised patches . Negative_regulation ANPEP CD14 7902377 234567 Like IL-4 , it *enhanced* the expression of CD11b , CD11c , CD18 , CD29 , CD49e ( VLA-5 ) , class II MHC , [CD13] , and CD23 , whereas it decreased the expression of CD64 , CD32 , CD16 , and in a dose dependent manner . Negative_regulation ANPEP JAG1 15492809 1321591 Cell proliferation assays were performed with MKN28 and , in which inhibition of CD10 significantly reduced the growth of both cell lines , and inhibition of [CD13] significantly *increased* the proliferation of the AGS cells , indicating that the ability to degrade gastrointestinal peptides may play an important role in the pathobiology of gastric cancer . Negative_regulation ANXA6 EPHB2 16824602 1666057 A specific inhibitor , U0126 , as well as PI3K inhibitors , differentially *regulated* IL-10 and IL-12 [p70] productions . Negative_regulation ANXA6 EPHB2 22715163 2634075 Lovastatin alone significantly reduced MPC and MTT cell viability at therapeutically relevant doses and *inhibited* both and AKT signalling , but increased [mTORC1/p70S6K] signalling . Negative_regulation ANXA6 FOXO1 17077083 1654889 Overexpression of wild type *enhances* [p70] S6K phosphorylation , whereas overexpression of TSC2 can reverse these effects . Negative_regulation ANXA6 SPHK1 21435724 2416931 Our data demonstrated that deficiency *enhanced* LPS induced [IL-12p70] production although SphK2 was present . Negative_regulation ANXA6 TLR7 18271077 1865806 Stimulation with TLR2 , TLR4 and ligands , as well as TLR3 ligand , *resulted* in significantly lower production of TNF-alpha , but neither IL-6 nor [IL-12p70] , by DCs from XLA patients in comparison to normal controls . Negative_regulation ANXA6 TNF 10373483 622586 *inhibited* [p70] ( s6k ) activation by glucose stimulated beta-cells of the islets of Langerhans in a dose- and time dependent manner , with maximal inhibition observed at approximately 20-50 ng/ml , detected after 24 and 48 h of exposure . Negative_regulation ANXA6 TNF 10373483 622587 Exogenous insulin failed to prevent *induced* inhibition of [p70] ( s6k ) , suggesting a defect in the insulin signaling pathway . Negative_regulation ANXA6 TNF 10373483 622588 Unexpectedly , and also interleukin 1 (IL-1) induced *inhibition* of [p70] ( s6k ) was completely prevented by inhibitors that block NO production . Negative_regulation ANXA6 TNF 10373483 622590 Furthermore , the ability of IL-1 receptor antagonist protein , IRAP , to block *induced* inhibition of [p70] ( s6k ) indicated that activation of intra-islet macrophages and the release of IL-1 that induces iNOS expression in beta-cells was responsible for the inhibitory effects of TNFalpha . Negative_regulation AOC3 MAOA 6694535 35690 Contribution of MAO-A , -B and SSAO to the metabolism of each substrate in each tissue was defined from experiments where the decrease of oxidative deamination of each substrate at a given concentration was measured as a function of increasing concentrations of a selective , -B or [SSAO] *inhibitor* . Negative_regulation AP1B1 EPHB2 12594266 1060830 Interestingly , transient activation *resulted* in altered AP-1 DNA binding activity and the induction of an [AP-1 complex] that was devoid of Fos protein and consisted of Jun-Jun dimers . Negative_regulation AP1B1 PLAU 15558021 1361111 Upregulation of JunB expression in MEKK1-/- cells forms an inhibitory [AP-1 complex] that binds to the uPA promoter and *inhibits* transcription . Negative_regulation AP1G1 EPHB2 12594266 1060831 Interestingly , transient activation *resulted* in altered AP-1 DNA binding activity and the induction of an [AP-1 complex] that was devoid of Fos protein and consisted of Jun-Jun dimers . Negative_regulation AP1G1 PLAU 15558021 1361112 Upregulation of JunB expression in MEKK1-/- cells forms an inhibitory [AP-1 complex] that binds to the uPA promoter and *inhibits* transcription . Negative_regulation APC AXIN2 15355978 1334088 We also show an unexpected *role* for in facilitating the ubiquitination-proteasome mediated down-regulation of [APC] through the oligomerization of Axin . Negative_regulation APC ID1 18372912 1938162 During late mitosis , binds to Cdh1 and disrupts the interaction between Cdh1 and APC , *resulting* in suppression of [APC] ( Cdh1 ) activity . Negative_regulation APC MMP28 11392606 823047 Recently , the serine protease , activated protein C (APC) , has been shown to directly activate gelatinase A , without requiring *Inhibition* of [APC] represents a selective approach to prevent gelatinase A activation and may prove to be of therapeutic benefit in RA . Negative_regulation APC MMP7 11392606 823062 Recently , the serine protease , activated protein C (APC) , has been shown to directly activate gelatinase A , without requiring *Inhibition* of [APC] represents a selective approach to prevent gelatinase A activation and may prove to be of therapeutic benefit in RA . Negative_regulation APOA1 IL1B 9617572 509718 The present results suggest that and TNF-alpha *suppress* hepatic [apo A-I] expression and secretion but not expression of apo E , which could contribute to the abnormal lipid metabolism in certain cytokine mediated inflammatory diseases . Negative_regulation APOA1 TNF 16475830 1524161 however , in the *presence* of , [apoAI] promoter activity was suppressed to an extent similar to that in cells not treated with SB202190 . Negative_regulation APOA1 TNF 16475830 1524164 These results suggest that *suppresses* [apoAI] promoter activity through both the MEK/ERK and JNK pathways but is not mediated by either p38 MAP kinase activity or NF-kappaB activation . Negative_regulation APOA1 TNF 22271762 2586215 these results elucidate the cell type-specific mechanism of the *mediated* regulation of [apoA-I] gene expression in monocytes and macrophages . Negative_regulation APOA1 TNF 23588423 2714270 In human hepatocytes , *inhibits* expression of [APO AI] , which may decrease the secretion of high density lipoproteins . Negative_regulation APOA1 TNF 8572227 340712 De novo synthesis of [apo A-I] , apo B-100 , and apo B-48 was also markedly *reduced* by . Negative_regulation APOA1 TNF 9617572 509717 The present results suggest that IL-1 beta and *suppress* hepatic [apo A-I] expression and secretion but not expression of apo E , which could contribute to the abnormal lipid metabolism in certain cytokine mediated inflammatory diseases . Negative_regulation APOB CLU 15961700 1446021 In monkeys , oral D- [ 113-122 ] rapidly *reduced* [lipoprotein lipid hydroperoxides (LOOH)] and improved HDL inflammatory properties . Negative_regulation APOB G0S2 23951308 2831720 Hepatic overexpression *resulted* in an increase in plasma Low-density lipoprotein (LDL)/Very-Low-density ( VLDL ) [lipoprotein] cholesterol level . Negative_regulation APOB GLP1R 19957161 2204073 activation with exendin-4 alone also decreased plasma and TRL-ApoB-48 in hamsters and mice , and *reduced* secretion of [ApoB-48] in hamster enterocyte cultures . Negative_regulation APOB GLP1R 22237690 2564105 Pharmacological augmentation of signalling by dipeptidyl peptidase 4 (DPP-4) inhibition *reduced* intestinal [lipoprotein] secretion in experimental studies , suggesting that DPP-4 inhibitors may ameliorate dyslipidaemia and thus reduce cardiovascular risk in patients with type 2 diabetes . Negative_regulation APOB IL1B 10734059 678608 Tumor necrosis factor-alpha and *inhibit* [apolipoprotein B] secretion in CaCo-2 cells via the epidermal growth factor receptor signaling pathway . Negative_regulation APOB IL1B 9419781 291237 Results demonstrated that treatment of cultured hepatocytes with TNF-alpha maximally inhibited Apo B production by 50 % at a half-maximal concentration of 100 pg/mL , whereas maximally *inhibited* [Apo B] production by 80 % at a half-maximal dose of 200 pg/mL . Negative_regulation APOB PCSK9 15118091 1244594 These results were confirmed in vitro by the demonstration that transfection of in McA-RH7777 cells *caused* a reduction in LDLR protein and [LDL] binding . Negative_regulation APOB PCSK9 15677715 1369862 Overexpression of in mice *leads* to increased total and [low-density lipoprotein (LDL)] cholesterol levels because of a decrease in hepatic LDL receptor (LDLR) protein with normal mRNA levels . Negative_regulation APOB PCSK9 17380167 1715368 Expression of normally downregulates the LDL-receptor pathway by indirectly causing degradation of LDL-receptor protein , and loss-of-function mutations in PCSK9 *result* in low plasma [LDL] levels . Negative_regulation APOB PCSK9 18354138 1906273 Plasma preferentially *reduces* liver [LDL] receptors in mice . Negative_regulation APOB PCSK9 19075777 2003117 Furthermore , deficiency *leads* to significantly lowered [LDL] cholesterol levels in humans and provides dramatic protection against coronary heart disease . Negative_regulation APOB PCSK9 23115612 2695870 The *role* of in the regulation of circulating low density [lipoprotein-cholesterol] ( LDL-c ) levels is ascribed to binding of circulating PCSK9 to the LDL receptor (LDLR) and subsequent lysosomal degradation of LDLR . Negative_regulation APOB PCSK9 23344002 2712774 2',4'-BNA-AON that targeted murine *induced* a dose dependent reduction in hepatic PCSK9 mRNA and [LDL cholesterol (LDL-C)] ; Negative_regulation APOB PCSK9 23714205 2853890 By downregulating LDLR , *reduces* hepatic clearance of [LDL-cholesterol] . Negative_regulation APOB TF 6323541 36635 Moreover , did not *prevent* the binding and uptake of fluorescent labeled [LDL] by activated lymphocytes . Negative_regulation APOB TNF 10734059 678607 and interleukin-1beta *inhibit* [apolipoprotein B] secretion in CaCo-2 cells via the epidermal growth factor receptor signaling pathway . Negative_regulation APOB TNF 8387950 218079 Comparison of the kinetics of specific low-density lipoprotein binding in the unstimulated cells and in the tumor necrosis factor stimulated cells indicated that tumor necrosis factor caused a 30 % increase in maximum velocity with no significant change in Michaelis constant , suggesting that *increases* the number of low-density [lipoprotein] receptors on the cells rather than changing binding affinity . Negative_regulation APOB TNF 8572227 340713 De novo synthesis of apo A-I , [apo B-100] , and apo B-48 was also markedly *reduced* by . Negative_regulation APOC3 TNF 9350999 460911 *Repression* of [apoC-III] gene expression by involves C/EBPdelta/NF-IL6beta via an IL-1 independent pathway . Negative_regulation APOE ARSA 15228221 1268923 ( 200 , 500 , and 1,000 microm ) *inhibited* both the lipid peroxidation and the oxidative modification of [apoE] . Negative_regulation APOE TNF 10686578 669859 After 48 h of incubation , [apoE] secretion was *inhibited* by but not affected by IL-1beta and IFN-gamma . Negative_regulation APOE TNF 18467438 1938868 *mediated* suppression of adipocyte [apolipoprotein E] gene transcription : primary role for the nuclear factor (NF)-kappaB pathway and NFkappaB p50 . Negative_regulation APOE TNF 18467438 1938869 We have previously reported that *reduces* adipocyte [apoE] , and the current studies were undertaken to evaluate the molecular mechanism for this regulation . Negative_regulation APOE TNF 18467438 1938871 Reduction of p50 expression using small interference RNA completely eliminated *mediated* reduction of endogenous adipocyte [apoE] gene expression . Negative_regulation APP ALOX5 17998412 1882721 Absence of <5LO> did not *induce* any significant change in [amyloid-beta precursor protein (APP)] levels and processing , or Abeta catabolic pathways . Negative_regulation APP EPHB2 18275940 1872072 We demonstrate additionally that specific inhibition during staurosporine induction , with serum-free conditions , *results* in down-regulation of [APP] phosphorylation at T668 , together with attenuation of the increased Abeta-secretory response . Negative_regulation APP IL1B 17549252 1752482 A beneficial *role* for in [Alzheimer disease] ? Negative_regulation APP TNF 1577876 187553 In cultures , GH , TNF-alpha and TGF-beta each inhibited lipid deposition , whereas and TGF-beta , but not GH , *inhibited* [AD-1] antigen expression . Negative_regulation AQP1 HES2 23741323 2797322 Group and Group HTS decreased pulmonary vascular permeability and Wet-to-dry lung weight ratio , improved arterial blood gas analysis and survival rates , and *attenuated* the decreased pulmonary expression of [aquaporin1] and aquaporin5 after the `` two-hit '' , comparing with groups NF and LR , but these beneficial effects were blunted in group HTS . Negative_regulation AQP3 EPHB2 18064629 1867987 inhibitors PD98059 and U0126 *inhibit* UV-induced down-regulation of [AQP3] . Negative_regulation AQP3 EPHB2 18214481 1943957 We also find that curcumin , a well known anti-ovarian cancer drug , down-regulates [AQP3] expression and reduces cell migration in CaOV3 , and the effects of curcumin are *mediated* , at least in part , by its inhibitory effects on EGFR and downstream activation . Negative_regulation AQP3 HSD11B2 17213730 1695863 A decreased expression of <11betaHSD2> may *result* in an upregulation of [AQP3] , in which AVP/cAMP dependent mechanisms are unlikely to be involved . Negative_regulation AQP3 MAP2K6 18064629 1867993 inhibitors PD98059 and U0126 *inhibit* UV-induced down-regulation of [AQP3] . Negative_regulation AQP3 TNF 19619514 2118174 TNF-alpha also decreased AQP3 mRNA expression and promoter activity , indicating that *suppresses* [AQP3] gene transcription . Negative_regulation AQP3 TNF 22531364 2793356 [AQP3] expression is downregulated in *response* to ( TNF- a ) . Negative_regulation AQP4 S100B 17984171 1850461 Finally , elevated levels of *induced* ROS and loss of [AQP4] expression led to increased programmed cell death . Negative_regulation AQP5 HES2 23741323 2797329 Group and Group HTS decreased pulmonary vascular permeability and Wet-to-dry lung weight ratio , improved arterial blood gas analysis and survival rates , and *attenuated* the decreased pulmonary expression of aquaporin1 and [aquaporin5] after the `` two-hit '' , comparing with groups NF and LR , but these beneficial effects were blunted in group HTS . Negative_regulation AQP5 TNF 11279049 819476 *inhibits* [aquaporin 5] expression in mouse lung epithelial cells . Negative_regulation AQP5 TNF 21973049 2629334 Although we also investigated the role of NF-?B activity in the *induced* suppression of [AQP5] expression in NS-SV-AC cells , we detected similar TNF-a suppression of AQP5 expression in non transfected cells and in a super-repressor form of I?Ba cDNA transfected cell clones . Negative_regulation AQP5 TNF 21973049 2629335 Therefore , our results may indicate that *inhibition* of [AQP5] expression in human salivary gland acinar cells is due to the epigenetic mechanism by suppression of acetylation of histone H4 . Negative_regulation AQP8 TNF 18174273 1862954 LPS induces the *mediated* downregulation of rat liver [aquaporin-8] : role in sepsis associated cholestasis . Negative_regulation AR CCND1 11714699 896987 We have shown previously that functions as a co-repressor to *inhibit* ligand dependent [androgen receptor] activation . Negative_regulation AR CCND1 20338923 2260573 Previous reports have shown that can directly enhance estrogen receptor activity and *inhibit* [androgen receptor] activity in a ligand independent manner and thus may play an important role in hormone-responsive malignancies . Negative_regulation AR FOXA1 21915096 2491961 Dual *role* of in [androgen receptor] binding to chromatin , androgen signalling and prostate cancer . Negative_regulation AR FOXO1 20930691 2332617 Nuclear deficiency *increases* [androgen receptor] transactivation and modifies the activity of important nuclear receptors and key genes involved in pilosebaceous keratinocyte proliferation , sebaceous lipogenesis and expression of perifollicular inflammatory cytokines . Negative_regulation AR PLAT 8119140 250589 Interestingly , whereas mRNA levels , like those of TGF beta 2 and -beta 3 , were barely detectable in adult prostatic tissues , mRNA levels for urokinase plasminogen activator , [androgen receptor] , and c-myc were readily *detected* and expressed in a lobe-specific fashion . Negative_regulation AR RGS2 16449965 1573909 ( RGS2 ) *inhibits* androgen independent activation of [androgen receptor] in prostate cancer cells . Negative_regulation AR TGM2 24656569 2938534 expression *promotes* castration-resistant phenotype and transcriptional repression of [androgen receptor] . Negative_regulation AR TNF 19934328 2172248 Knocking down TRADD expression in LNCaP cells impaired *induced* NF-kappaB activation and [androgen receptor] repression , whereas overexpression of TRADD in C4-2B cells restored their sensitivity to TNF-alpha . Negative_regulation AR UGT1A7 18471784 1910400 On the other hand , inhibition of expression by small interfering RNA ( siRNA ) *resulted* in an induced response to DHT of [androgen-receptor] target genes such as PSA , KLK4 , NKX3.1 , TMPRSS2 , SLC16A6 and VEGF . Negative_regulation ARAF MAP2K6 12364324 1019066 GLP1 stimulated activation of Erk is blocked by inhibitors of , but GLP1 does not *induce* the activation of [A-Raf] , B-Raf , C-Raf , or Ras . Negative_regulation ARAF2P ARSA 11535802 854793 By contrast , expression of [PKS1] was severely *impaired* by , although catalytic activity of a polyketide synthase ( PKS1 ) was not inhibited by AsA . Negative_regulation ARF1 TNF 16467041 1523420 These findings suggest that the *role* of in [ARF] may be in linkage disequilibrium with some other severity genes not yet genetically determined . Negative_regulation ARF3 TNF 16467041 1523421 These findings suggest that the *role* of in [ARF] may be in linkage disequilibrium with some other severity genes not yet genetically determined . Negative_regulation ARF4 TNF 16467041 1523422 These findings suggest that the *role* of in [ARF] may be in linkage disequilibrium with some other severity genes not yet genetically determined . Negative_regulation ARF5 TNF 16467041 1523423 These findings suggest that the *role* of in [ARF] may be in linkage disequilibrium with some other severity genes not yet genetically determined . Negative_regulation ARF6 EPHB2 24955982 2947307 Our results indicate that ET-1 induces , through endothelin type A receptor (ETAR) , lipolysis , the ARF6 activation and extracellular-signal regulated kinase ( ERK ) phosphorylation in adipocytes , further ET-1 stimulated lipolysis is inhibited by the *inhibitors* of [ARF6] activation , phosphorylation and dynamin , which is essential for endocytosis . Negative_regulation ARF6 RGS2 10779358 687245 The bombesin elicited translocation of vesicular [ARF6] was mimicked by activated Galphaq and was partially *inhibited* by expression of , which down regulates Gq function . Negative_regulation ARF6 TNF 16467041 1523424 These findings suggest that the *role* of in [ARF] may be in linkage disequilibrium with some other severity genes not yet genetically determined . Negative_regulation ARG1 IL1B 9245484 446672 mediated *inhibition* of [arginase] in RINm5F cells . Negative_regulation ARG1 TP63 19106413 2031553 This was indicated by significantly increased nuclear translocation of nuclear factor kappaB , as well as production of , tumor necrosis factor alpha , and interleukin-6 , and *reduced* expression of [arginase-I] . Negative_regulation ARG2 IL1B 9245484 446673 mediated *inhibition* of [arginase] in RINm5F cells . Negative_regulation ARG2 STK39 18621907 1966316 Together , the data demonstrate a central *role* of in the upregulation of both [arginase II] and iNOS in bPAEC in response to L/T treatment . Negative_regulation ARID4B TNF 7691816 230979 In addition the cytokines interleukin-1 , -6 , and *mediate* a decrease in hepatic [SAP] ( FP ) transcript levels in female hamsters but did not cause a significant elevation of SAP ( FP ) mRNA in livers of male hamsters . Negative_regulation ARL4C MYLIP 22673513 2611344 Here , we describe that , an LXR suppressed miRNA , *inhibits* the expression of the ATP binding cassette transporter A1 ( ABCA1 ) and [ADP-ribosylation factor-like 7 (ARL7)] , two LXR target genes which play critical roles in cholesterol efflux . Negative_regulation ARRB1 MAP2K6 12167719 973476 This insulin induced decrease in [beta-arrestin-1] content was *blocked* by inhibition of phosphatidylinositol-3 kinase ( PI-3 kinase ) and with wortmannin and PD98059 , respectively . Negative_regulation ARRB2 PTGER2 11418617 849793 Signaling via endogenous EP4 receptors in CHO-K1 cells was attenuated by ARR2-GFP expression , whereas [ARR2] ( R169E ) -GFP expression in HASM *inhibited* receptor mediated cAMP production . Negative_regulation ARSA ARSB 2879581 66507 [Arylsulfatase A] was *inhibited* by sulfate , sulfite , silver , magnesium , manganese and calcium ions and by chloride , sulfate , sulfite and silver ions . Negative_regulation ARSA ASL 22541557 2590355 Congenital deficiency *causes* [argininosuccinic aciduria (ASA)] , the second most common urea-cycle disorder , and leads to deficiency of both ureagenesis and NO production . Negative_regulation ARSA CASP1 18612824 2010579 Our results indicate that [ASA] in the *presence* of inhibitors causes gastric mucosal cell death through a caspase independent pathway suggestive of apoptosis-like programmed cell death . Negative_regulation ARSA CASP10 18612824 2010580 Our results indicate that [ASA] in the *presence* of inhibitors causes gastric mucosal cell death through a caspase independent pathway suggestive of apoptosis-like programmed cell death . Negative_regulation ARSA CASP12 18612824 2010590 Our results indicate that [ASA] in the *presence* of inhibitors causes gastric mucosal cell death through a caspase independent pathway suggestive of apoptosis-like programmed cell death . Negative_regulation ARSA CASP14 18612824 2010581 Our results indicate that [ASA] in the *presence* of inhibitors causes gastric mucosal cell death through a caspase independent pathway suggestive of apoptosis-like programmed cell death . Negative_regulation ARSA CASP16 18612824 2010591 Our results indicate that [ASA] in the *presence* of inhibitors causes gastric mucosal cell death through a caspase independent pathway suggestive of apoptosis-like programmed cell death . Negative_regulation ARSA CASP2 18612824 2010582 Our results indicate that [ASA] in the *presence* of inhibitors causes gastric mucosal cell death through a caspase independent pathway suggestive of apoptosis-like programmed cell death . Negative_regulation ARSA CASP3 18612824 2010583 Our results indicate that [ASA] in the *presence* of inhibitors causes gastric mucosal cell death through a caspase independent pathway suggestive of apoptosis-like programmed cell death . Negative_regulation ARSA CASP4 18612824 2010584 Our results indicate that [ASA] in the *presence* of inhibitors causes gastric mucosal cell death through a caspase independent pathway suggestive of apoptosis-like programmed cell death . Negative_regulation ARSA CASP5 18612824 2010585 Our results indicate that [ASA] in the *presence* of inhibitors causes gastric mucosal cell death through a caspase independent pathway suggestive of apoptosis-like programmed cell death . Negative_regulation ARSA CASP6 18612824 2010586 Our results indicate that [ASA] in the *presence* of inhibitors causes gastric mucosal cell death through a caspase independent pathway suggestive of apoptosis-like programmed cell death . Negative_regulation ARSA CASP7 18612824 2010587 Our results indicate that [ASA] in the *presence* of inhibitors causes gastric mucosal cell death through a caspase independent pathway suggestive of apoptosis-like programmed cell death . Negative_regulation ARSA CASP8 18612824 2010588 Our results indicate that [ASA] in the *presence* of inhibitors causes gastric mucosal cell death through a caspase independent pathway suggestive of apoptosis-like programmed cell death . Negative_regulation ARSA CASP9 18612824 2010589 Our results indicate that [ASA] in the *presence* of inhibitors causes gastric mucosal cell death through a caspase independent pathway suggestive of apoptosis-like programmed cell death . Negative_regulation ARSA CAT 24085115 2857986 However , in the *presence* of neutralizing H2O2 , [AsA] alone or in combination with X-irradiation only slightly decreased the intercellular ROS . Negative_regulation ARSA CCND1 10753205 681730 Overexpression of was *induced* by BBN but not [Na-AsA] and the degree of overexpression was higher in the order simple hyperplasia , papillary or nodular hyperplasia , papilloma and carcinoma . Negative_regulation ARSA COPS5 23424245 2760022 Together , our data reveal a regulatory *role* of in light-dark regulation of [AsA] synthesis . Negative_regulation ARSA CPOX 24204637 2864602 However , the variable clinical response to [5-ASA] and frequent deterioration in *response* to inhibitors , has prompted an in depth simultaneous evaluation of multiple lipid mediators ( including eicosanoids ) within the inflammatory milieu in UC . Negative_regulation ARSA MPI 18755683 1975327 Moreover , a reduction of expression through RNA interference *resulted* in a substantial decrease in the total [AsA] content of leaves of knockdown PMI1 plants , whereas the complete inhibition of PMI2 expression did not affect the total AsA levels in leaves of knock-out PMI2 plants . Negative_regulation ARSA PRG2 1433013 204580 TA did not depress chondroformative variables in human cartilage in vitro , while [ASA] *induced* a decrease of DNA and syntheses . Negative_regulation ARSA PRG3 1433013 204581 TA did not depress chondroformative variables in human cartilage in vitro , while [ASA] *induced* a decrease of DNA and syntheses . Negative_regulation ARSA PRG4 1433013 204582 TA did not depress chondroformative variables in human cartilage in vitro , while [ASA] *induced* a decrease of DNA and syntheses . Negative_regulation ARSA PTGS2 15763541 1383556 Interestingly , the expression of was not *inhibited* at 1mM [ASA] , but was even enhanced significantly . Negative_regulation ARSA PTGS2 20062937 2193831 *inhibition* produced by residual [ASA] is the probable cause of ischaemic accidents and drug eluting stents thrombosis a few days after ASA withdrawal . Negative_regulation ARSA TJP1 22917627 2683141 We measured whether [ASA] *induced* the increase of differentiated Caco-2 permeability , the decrease of expression , the production of reactive oxygen species ( ROS ) , and the expression of ROS modified zonula occludens-1 (ZO-1) protein . Negative_regulation ARSA TJP2 22917627 2683142 We measured whether [ASA] *induced* the increase of differentiated Caco-2 permeability , the decrease of expression , the production of reactive oxygen species ( ROS ) , and the expression of ROS modified zonula occludens-1 (ZO-1) protein . Negative_regulation ARSA TJP3 22917627 2683143 We measured whether [ASA] *induced* the increase of differentiated Caco-2 permeability , the decrease of expression , the production of reactive oxygen species ( ROS ) , and the expression of ROS modified zonula occludens-1 (ZO-1) protein . Negative_regulation ART1 FAS 8977313 403295 IFN-alpha2 did not alter the induced activity of Mitogen activated protein kinase (MAPK) 1 and did not *inhibit* the Apo-1/Fas mediated proteolytic cleavage of [ADP-ribosyltransferase] , a substrate of Interleukin-beta1 converting enzyme ( ICE ) and homologues . Negative_regulation ART3 FAS 8977313 403310 IFN-alpha2 did not alter the induced activity of Mitogen activated protein kinase (MAPK) 1 and did not *inhibit* the Apo-1/Fas mediated proteolytic cleavage of [ADP-ribosyltransferase] , a substrate of Interleukin-beta1 converting enzyme ( ICE ) and homologues . Negative_regulation ART4 FAS 8977313 403325 IFN-alpha2 did not alter the induced activity of Mitogen activated protein kinase (MAPK) 1 and did not *inhibit* the Apo-1/Fas mediated proteolytic cleavage of [ADP-ribosyltransferase] , a substrate of Interleukin-beta1 converting enzyme ( ICE ) and homologues . Negative_regulation ART5 FAS 8977313 403228 IFN-alpha2 did not alter the induced activity of Mitogen activated protein kinase (MAPK) 1 and did not *inhibit* the Apo-1/Fas mediated proteolytic cleavage of [ADP-ribosyltransferase] , a substrate of Interleukin-beta1 converting enzyme ( ICE ) and homologues . Negative_regulation ASIC3 EPHB2 17696763 1829737 Moreover , inhibition of activity by dominant negative-mitogen activated protein kinase kinase ( DN-MEK ) *resulted* in a dose dependent suppression of [ASIC3] basal promoter activity , whereas overexpression of constitutively active MEK1 caused an increase in ASIC3 promoter activity . Negative_regulation ASIP FAS 9637525 513850 Indeed , ligation of both and BCR *resulted* in cleavage of the IL-1beta converting enzyme/Ced-3-like protease caspase 3 and its substrates [Ac-Asp-Glu-Val-Asp-aldehyde] and poly ( ADP-ribose ) polymerase . Negative_regulation ASS1 TNF 17496212 1772435 *reduces* [argininosuccinate synthase] expression and nitric oxide production in aortic endothelial cells . Negative_regulation ASS1 TNF 24401210 2900320 T0901317 influenced NO metabolism as indicated by a decrease in TNF-a upregulated arginase activity , a reversal of *induced* downregulation of [argininosuccinate synthase] mRNA expression and eNOS expression to basal levels and a raise in NO production . Negative_regulation ATF1 CCND1 15205322 1261183 Repression of by p16(INK4a) occurred independently of the p16(INK4a)-cdk4 binding function and *required* a cAMP-response [element/activating transcription factor-2] binding site . Negative_regulation ATF2 CCND1 15205322 1261185 Repression of by p16(INK4a) occurred independently of the p16(INK4a)-cdk4 binding function and *required* a cAMP-response [element/activating transcription factor-2] binding site . Negative_regulation ATF2 MAP2K6 16050133 1438527 In contrast , the inhibitor , PD98059 , or the JNK inhibitor , SP600125 , *had* no significant effect on DNA binding of [ATF-2] . Negative_regulation ATF3 CCND1 15205322 1261187 Repression of by p16(INK4a) occurred independently of the p16(INK4a)-cdk4 binding function and *required* a cAMP-response [element/activating transcription factor-2] binding site . Negative_regulation ATF3 ID1 21554132 2435388 Further work is needed to determine the molecular mechanism ( s ) responsible for the regulation of Id1 and to determine if biological activity of [ATF3] overexpression is *mediated* by repression of by these compounds . Negative_regulation ATF4 CCND1 15205322 1261189 Repression of by p16(INK4a) occurred independently of the p16(INK4a)-cdk4 binding function and *required* a cAMP-response [element/activating transcription factor-2] binding site . Negative_regulation ATF4 EGLN3 21951999 2502558 Coexpression of PHD1 or with ATF4 *repressed* the transcriptional activity of [ATF4] . Negative_regulation ATF5 CCND1 15205322 1261191 Repression of by p16(INK4a) occurred independently of the p16(INK4a)-cdk4 binding function and *required* a cAMP-response [element/activating transcription factor-2] binding site . Negative_regulation ATF6 CCND1 15205322 1261193 Repression of by p16(INK4a) occurred independently of the p16(INK4a)-cdk4 binding function and *required* a cAMP-response [element/activating transcription factor-2] binding site . Negative_regulation ATF7 CCND1 15205322 1261195 Repression of by p16(INK4a) occurred independently of the p16(INK4a)-cdk4 binding function and *required* a cAMP-response [element/activating transcription factor-2] binding site . Negative_regulation ATG4B CAPN8 21854730 2505676 Immunoblot , autophagic flux , genetic , and imaging analyses all associated the increase in sensitivity to I/R injury with age with decreased autophagy and subsequent mitochondrial dysfunction due to *mediated* loss of [Atg4B] . Negative_regulation ATOH1 IFI27 17113786 1677131 Overexpression of the prosensory transcription factor , [Math1] , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation ATP2A2 MAP2K6 12829175 1105210 ( Glu ) prolonged decay of the contractile calcium transients , downregulated SERCA2 expression , and *reduced* the activity of the rat [SERCA2] gene promoter . Negative_regulation ATP5J TNF 15158150 1250634 We investigated the *role* of in the generation and release of [CF6] . Negative_regulation ATP5O ABCA4 11278627 798298 Photodamage to causes it to aggregate in SDS gels and *results* in the loss of retinal stimulated [ATPase] activity . Negative_regulation ATP5O ABCG2 11437380 832778 Here we report that the expression of the protein in Sf9 insect cells *resulted* in a high-capacity , vanadate-sensitive [ATPase] activity in isolated membrane preparations . Negative_regulation ATP5O CA12 6302706 27494 NB did not inhibit in whole stomach homogenates of guinea pig , but did *inhibit* the potassium stimulated gastric microsomal [ATPase] . Negative_regulation ATP5O CAPN8 20884028 2401473 Right ventricular troponin I was degraded by increased activity , and protein levels of sarco ( endo ) plasmic reticulum calcium [ATPase] were *reduced* in both ventricles . Negative_regulation ATP5O EDN2 2549995 117489 At high concentrations , ( 10 ( -5 ) M ) *inhibited* [Na-K-ATPase] in vitro . Negative_regulation ATP5O EDN2 2558568 123342 In contrast to the response observed in intact cells , in permeabilized IMCD cells did not *inhibit* ouabain-sensitive [ATPase] . Negative_regulation ATP5O EDN2 2558568 123345 Several observations indicated that prostaglandin E2 ( PGE2 ) mediates *inhibition* of Na ( + ) -K ( + ) [-ATPase] activity . Negative_regulation ATP5O EPHB2 10712238 673939 These findings suggest that Na ( + ) -K ( + ) [-ATPase] inhibition by bufalin *induces* calcium influx and thereby activates PKC and . Negative_regulation ATP5O IL1B 12433284 1015679 *inhibited* , in a dose dependent manner , the activity of Na ( + ) /K ( + ) [-ATPase] in villus and crypt jejunal cells and in medullary and cortical kidney cells . Negative_regulation ATP5O IL1B 12957788 1137950 These results indicate that *reduces* the expression of [ATPase] independently of NFkB but , through a major pathway involving p38 and COX-2/PGE2 , and another pathway involving JNK/AP1 . Negative_regulation ATP5O IL1B 14985981 1236663 *reduces* the activity and protein expression of Na ( + ) -K ( + ) [-ATPase] in rat kidney cells . Negative_regulation ATP5O IL1B 15016405 1220838 *inhibits* Na+-K+ [ATPase] activity and protein expression in cardiac myocytes . Negative_regulation ATP5O IL1B 9314830 455702 induced transcripts for inducible NO synthase (iNOS) , did not alter GAPDH transcripts , and *reduced* sarcoplasmic reticulum Ca ( 2+ ) [-ATPase] ( 65 % of control , P < .001 ) transcripts . Negative_regulation ATP5O JAG1 2825594 80942 The Na+ , K+-ATPase from brain or kidney and sarcoplasmic reticulum ( SR ) [Ca2+-ATPase] were *inhibited* potently by agelasidine C ( Agd-C ) and , the bioactive principles of sea sponge , while Agd-C and Ags-B exerted less potent inhibition of heart Na+ , K+-ATPase . Negative_regulation ATP5O MAP2K6 15277314 1282820 Inhibition of Raf-1 , ( MAPKK/MEK ) , p38 MAPK and STAT1 with , respectively , GW 5074 , PD 98059 , SB 203580 and epigallocatechin gallate *prevented* inhibition of Na ( + ) -K ( + ) [-ATPase] activity by IFN-gamma . Negative_regulation ATP5O MUC16 11885694 919860 Butanol fraction showed significant increase in secretion , and *inhibited* malondialdehyde ( MDA ) and H+/ [K+ATPase] activity in the stomach . Negative_regulation ATP5O TMOD1 9553120 499519 Our results show the following : ( i ) the NH2-terminal region of troponin T activates the actomyosin ATPase in the presence of tropomyosin; (ii) the interaction of the globular domain of troponin T with the *blocks* [ATPase] activation in the absence of Ca2+ ; Negative_regulation ATP5O TNF 15935952 1415108 inhibited net water and chloride absorption , down-regulated in both surface and crypt colonocytes the Na+-K+-2Cl- cotransporter , and *reduced* the protein expression and activity of the Na+-K+ [ATPase] . Negative_regulation ATP5O TNF 18348163 1925285 JNK modulates the effect of caspases and NF-kappaB in the *induced* down-regulation of [Na+/K+ATPase] in HepG2 cells . Negative_regulation ATP5O TNF 19148111 2037988 ( 3 ) Digibind had no effects on TNFalpha induced upregulation of extracellular signal regulated kinase phosphorylation , but could block *induced* downregulation of Na ( + ) /K ( + ) [-ATPase] beta1 expression . Negative_regulation ATP5O TNF 20222869 2254374 *reduces* the Na+/K+ [ATPase] activity in LLC-PK1 cells by activating caspases and JNK and inhibiting NF-kappaB . Negative_regulation ATP5O TNF 9142647 428525 and transforming growth factor-beta 1 ( TGF-beta 1 ) *inhibit* the expression and activity of Na+/K ( + ) [-ATPase] in FRTL-5 rat thyroid cells . Negative_regulation ATP5O TNF 9142647 428526 Na+/K ( + ) [-ATPase] activity , which drives iodide uptake by thyroid cells , is *inhibited* by and TGF-beta . Negative_regulation ATP5O TNF 9865597 556279 The release of *required* both a Ca2 ( + ) [-ATPase] inhibitor and 12-O-tetradecanoylphorbol-13-acetate ( TPA ) . Negative_regulation ATP8A2 ARSA 7589376 334028 When compared to placebo , inhaled *reduced* the airway responsiveness to AMP in all the subjects studied , the geometric mean ( range ) values for PC20 AMP increasing significantly from 36.3 ( 7.9-250.5 ) to 101.8 ( 27.2-1300 ) mg . [ml-1] after placebo and L-ASA , respectively . Negative_regulation ATR IFI27 16968694 1639986 Ras stimulated [ATR] activity , as evidenced by Chk1 and p53 phosphorylation , was *blocked* by , suggesting that cell cycle progression triggers checkpoint activation , likely as a consequence of replication stress . Negative_regulation AVEN NES 20935510 2337806 Disruption of this by site directed mutagenesis *resulted* in enhanced nuclear localization of [Aven] , but did not alter the ability of the protein to induce G ( 2 ) /M cell cycle arrest in interphase Xenopus laevis extracts . Negative_regulation AVP MAOA 12605405 1062776 The deficiency *caused* an increase in [AVP] and VIP expression ( determined by immunohistochemistry , enzyme immunoassay , and in situ hybridization ) compared to C3H mice . Negative_regulation AVPR2 RGS2 17475820 1744141 It is proposed that is *involved* in negative feedback regulation of [V2R] signaling . Negative_regulation AXIN2 APC 12072559 956659 Altered nuclear expression of [axin] seen in colon polyps and carcinomas may be a *consequence* of the loss of full-length and the advent of nuclear beta-catenin . Negative_regulation AXIN2 APC 17189293 1688437 Second , reduction of the levels of truncated by RNA interference increases the activity of a beta-catenin dependent reporter gene and *stimulates* the expression of the beta-catenin target gene [AXIN2/conductin] . Negative_regulation AXIN2 CTNNB1 10722668 677120 Down-regulation of by the colorectal tumor suppressor APC *requires* association with [Axin] and beta-catenin . Negative_regulation AXIN2 DAB2 12805222 1101605 Wnt stimulation leads to a time dependent dissociation of endogenous Dab2-Dvl-3 and Dvl-3-axin interactions in NIH-3T3 cells , while overexpression *leads* to maintenance of Dab2-Dvl-3 association and subsequent loss of [Dvl-3-axin] interactions . Negative_regulation AXIN2 DAB2 17922036 1882539 levels induced during retinoic acid induced differentiation of F9 , or during transforming growth factor-beta induced epithelial-mesenchymal transdifferentiation of mouse mammary epithelial cells *result* in the stabilization of [Axin] and concomitant inhibition of beta-catenin signaling . Negative_regulation AXIN2 DAB2 17922036 1882544 Ectopic expression of in F9 cells as well as in transformed cell lines *results* in increased [Axin] expression and attenuation of Wnt mediated signaling . Negative_regulation AXIN2 DAB2 19581931 2122482 Here , we show that functions upstream of PP1 to *block* the interaction between [Axin] and PP1 , inhibiting Axin dephosphorylation and thereby stabilizing its expression , ultimately leading to inhibition of Wnt/beta-catenin . Negative_regulation AXIN2 DVL1 10196136 604288 , which was genetically shown to function upstream of GSK-3beta , *inhibited* the phosphorylation of [Axin] by GSK-3beta in vitro . Negative_regulation AXIN2 DVL1 16303557 1485391 In the `` canonical '' Wnt signaling pathway , is required to functionally *inhibit* the activity of the [GSK3beta/Axin] complex and thereby stabilize beta-catenin . Negative_regulation AXIN2 DVL2 16303557 1485392 In the `` canonical '' Wnt signaling pathway , is *required* to functionally inhibit the activity of the [GSK3beta/Axin] complex and thereby stabilize beta-catenin . Negative_regulation AXIN2 DVL3 16303557 1485393 In the `` canonical '' Wnt signaling pathway , is required to functionally *inhibit* the activity of the [GSK3beta/Axin] complex and thereby stabilize beta-catenin . Negative_regulation AXIN2 FRAT1 15699046 1388701 We propose that recruitment of Axin and Frat1 to the membrane by LRP5 leads to both [Axin] degradation and mediated *inhibition* of glycogen synthase kinase-3 . Negative_regulation AXIN2 GYS1 20974802 2365398 These phosphorylated motifs are required to recruit [axin] and to *inhibit* , two basic components of the ß-catenin destruction complex . Negative_regulation AXIN2 GYS2 20974802 2365399 These phosphorylated motifs are required to recruit [axin] and to *inhibit* , two basic components of the ß-catenin destruction complex . Negative_regulation AXIN2 HDAC3 23300083 2742249 Together , these studies identify a key mechanistic pathway for regulating intramembranous bone development within the skull that involves Runx2- and *mediated* suppression of [Axin2] to prevent the untimely closure of the calvarial sutures . Negative_regulation AXIN2 HINT1 16014379 1431902 Consistent with these observations , *represses* expression of the endogenous target genes cyclin D1 and [axin2] whereas knockdown of Hint1/PKCI by RNA interference increases their expression . Negative_regulation AXIN2 IDS 24667606 2934892 The repressed luciferase reporter activity , bound their genomic target sites , and *repressed* [AXIN2] and MYC expression in HEK293 cells . Negative_regulation AXIN2 IDS 24667606 2934894 The *repressed* [AXIN2] and MYC expression in these cells , which suggests that dTALEs could offer an effective therapeutic strategy for the treatment of colorectal cancer . Negative_regulation AXIN2 LEF1 11854293 929341 stimulated expression of a known beta-catenin target ( E-cadherin ) , *suppressed* expression of Apc and [Axin] , and induced apoptosis in 129/Sv but not in neighboring B6-ROSA26 epithelial cells . Negative_regulation AXIN2 MAP3K1 12878610 1142595 Expression of specific small interfering RNA against MEKK4 effectively attenuates JNK activation by the binding-defective Axin mutant in 293T cells and *inhibits* JNK activation by wild-type [Axin] in MEKK1-/- cells , confirming that MEKK4 is indeed another mitogen activated protein kinase kinase kinase that is specifically involved in Axin mediated JNK activation independently of MEKK1 . Negative_regulation AXIN2 MYLIP 23624843 2790506 p53 regulates nuclear GSK-3 levels through *mediated* [Axin2] suppression in colorectal cancer cells . Negative_regulation AXIN2 MYLIP 23624843 2790514 In this study , we report that p53 regulates GSK-3ß nuclear localization via *mediated* suppression of [Axin2] in colorectal cancer . Negative_regulation AXIN2 MYLIP 24166197 2902972 In addition , [Axin2] was *down-regulated* by approximately 50 % by over expressed at both the mRNA and protein levels . Negative_regulation AXIN2 MYLIP 24166197 2902973 The luciferase assay showed that over expressed in KB oral cancer cells *suppressed* [AXIN2] expression through an interaction with its own binding site at AXIN2 3'UTR ( 64-92 ) . Negative_regulation AXIN2 NR4A2 21362399 2415774 In addition , *inhibited* ß-catenin mediated expression of [Axin2] in MC3T3-E1 cells . Negative_regulation AXIN2 PC 19464575 2084976 153 *reduced* basal [Axin2] mRNA levels and it inhibited induction of Axin2 expression by recombinant mouse Wnt3a . Negative_regulation AXIN2 PPM1D 23405243 2743725 Thus , loss of [?H2AX in] vivo could be *due* , in part , to increased expression and activity of in the presence of Tax . Negative_regulation AXIN2 PRMT1 21242974 2425509 We found that the transient expression of led to an increased level of Axin and that knockdown of endogenous PRMT1 by short hairpin RNA *reduced* the level of [Axin] . Negative_regulation AXIN2 PRMT1 21242974 2425513 Consistent with the *role* of in the regulation of [Axin] , knockdown of PRMT1 enhanced the level of cytoplasmic ß-catenin as well as ß-catenin dependent transcription activity . Negative_regulation AXIN2 RUNX2 23300083 2742246 Here we demonstrate that Runx2 binds several regions of the Axin2 promoter and that *mediated* repression of [Axin2] transcription depends on Hdac3 . Negative_regulation AXIN2 SMURF2 20858899 2342929 Transient expression of *down-regulated* the level of [Axin] and increased the ubiquitination of Axin . Negative_regulation AXIN2 TNKS 22440753 2606680 Inhibition of poly ( ADP-ribosyl ) ation activity by JW55 *led* to stabilization of [AXIN2] , a member of the ß-catenin destruction complex , followed by increased degradation of ß-catenin . Negative_regulation AXIN2 TP53 23588680 2772997 In addition , ectopic expression of Axin by transient transfection of C6 cells with rAxin revealed that overexpression of [Axin] *induced* cell cycle arrest and apoptosis with an upregulation of . Negative_regulation AXIN2 WNT1 12781135 1095621 induced *inhibition* of the [Axin] complex depends on Dishevelled ( Dsh ) , a cytoplasmic protein that can bind to Axin , but the mechanism of this inhibition is not understood . Negative_regulation AXIN2 WNT1 15972957 1424302 Further , the interaction between TSC1/TSC2 and components of the beta-catenin degradation complex was dependent on Wnt stimulation such that binding of tuberin to GSK3 and [Axin] was reduced in the *presence* of whereas the tuberin Dishevelled interaction was increased . Negative_regulation AXIN2 WNT1 16303557 1485408 We further demonstrate that depletion of Galpha ( o ) or Galpha ( q ) will inhibit , respectively , the *induced* disruption of [GSK3beta/Axin2] and GSK3beta/Axin complexes and diminish Wnt stabilization of beta-catenin . Negative_regulation AXIN2 WNT1 16303557 1485467 We conclude that rapid disruption of [GSK3beta/Axin] interactions in *response* to leads to the initial stabilization of beta-catenin and that Galpha ( o ) and Galpha ( q ) signaling contributes to Wnt mediated GSK3beta/Axin disruption and the ultimate stabilization of beta-catenin . Negative_regulation AXIN2 WNT1 19888210 2161355 We show that Ube2m interacts with and modulates beta-catenin stability , and that the antagonistic effect of Nkd1 on signaling *requires* interaction with [Axin] , itself a negative pathway regulator . Negative_regulation AXIN2 WNT11 12781135 1095622 *induced* inhibition of the [Axin] complex depends on Dishevelled ( Dsh ) , a cytoplasmic protein that can bind to Axin , but the mechanism of this inhibition is not understood . Negative_regulation AXIN2 WNT11 15972957 1424303 Further , the interaction between TSC1/TSC2 and components of the beta-catenin degradation complex was dependent on Wnt stimulation such that binding of tuberin to GSK3 and [Axin] was *reduced* in the presence of whereas the tuberin Dishevelled interaction was increased . Negative_regulation AXIN2 WNT11 16303557 1485409 We further demonstrate that depletion of Galpha ( o ) or Galpha ( q ) will inhibit , respectively , the *induced* disruption of [GSK3beta/Axin2] and GSK3beta/Axin complexes and diminish Wnt stabilization of beta-catenin . Negative_regulation AXIN2 WNT11 16303557 1485468 We conclude that rapid disruption of [GSK3beta/Axin] interactions in *response* to leads to the initial stabilization of beta-catenin and that Galpha ( o ) and Galpha ( q ) signaling contributes to Wnt mediated GSK3beta/Axin disruption and the ultimate stabilization of beta-catenin . Negative_regulation AXIN2 WNT11 19888210 2161356 We show that Ube2m interacts with and modulates beta-catenin stability , and that the antagonistic effect of Nkd1 on signaling *requires* interaction with [Axin] , itself a negative pathway regulator . Negative_regulation AXIN2 WNT16 12781135 1095627 *induced* inhibition of the [Axin] complex depends on Dishevelled ( Dsh ) , a cytoplasmic protein that can bind to Axin , but the mechanism of this inhibition is not understood . Negative_regulation AXIN2 WNT16 15972957 1424308 Further , the interaction between TSC1/TSC2 and components of the beta-catenin degradation complex was dependent on Wnt stimulation such that binding of tuberin to GSK3 and [Axin] was *reduced* in the presence of whereas the tuberin Dishevelled interaction was increased . Negative_regulation AXIN2 WNT16 16303557 1485414 We further demonstrate that depletion of Galpha ( o ) or Galpha ( q ) will inhibit , respectively , the *induced* disruption of [GSK3beta/Axin2] and GSK3beta/Axin complexes and diminish Wnt stabilization of beta-catenin . Negative_regulation AXIN2 WNT16 16303557 1485473 We conclude that rapid disruption of [GSK3beta/Axin] interactions in *response* to leads to the initial stabilization of beta-catenin and that Galpha ( o ) and Galpha ( q ) signaling contributes to Wnt mediated GSK3beta/Axin disruption and the ultimate stabilization of beta-catenin . Negative_regulation AXIN2 WNT16 19888210 2161361 We show that Ube2m interacts with and modulates beta-catenin stability , and that the antagonistic effect of Nkd1 on signaling *requires* interaction with [Axin] , itself a negative pathway regulator . Negative_regulation AXIN2 WNT2 12781135 1095623 induced *inhibition* of the [Axin] complex depends on Dishevelled ( Dsh ) , a cytoplasmic protein that can bind to Axin , but the mechanism of this inhibition is not understood . Negative_regulation AXIN2 WNT2 15972957 1424304 Further , the interaction between TSC1/TSC2 and components of the beta-catenin degradation complex was dependent on Wnt stimulation such that binding of tuberin to GSK3 and [Axin] was reduced in the *presence* of whereas the tuberin Dishevelled interaction was increased . Negative_regulation AXIN2 WNT2 16303557 1485410 We further demonstrate that depletion of Galpha ( o ) or Galpha ( q ) will inhibit , respectively , the *induced* disruption of [GSK3beta/Axin2] and GSK3beta/Axin complexes and diminish Wnt stabilization of beta-catenin . Negative_regulation AXIN2 WNT2 16303557 1485469 We conclude that rapid disruption of [GSK3beta/Axin] interactions in *response* to leads to the initial stabilization of beta-catenin and that Galpha ( o ) and Galpha ( q ) signaling contributes to Wnt mediated GSK3beta/Axin disruption and the ultimate stabilization of beta-catenin . Negative_regulation AXIN2 WNT2 19888210 2161357 We show that Ube2m interacts with and modulates beta-catenin stability , and that the antagonistic effect of Nkd1 on signaling *requires* interaction with [Axin] , itself a negative pathway regulator . Negative_regulation AXIN2 WNT3 12781135 1095624 induced *inhibition* of the [Axin] complex depends on Dishevelled ( Dsh ) , a cytoplasmic protein that can bind to Axin , but the mechanism of this inhibition is not understood . Negative_regulation AXIN2 WNT3 15972957 1424305 Further , the interaction between TSC1/TSC2 and components of the beta-catenin degradation complex was dependent on Wnt stimulation such that binding of tuberin to GSK3 and [Axin] was *reduced* in the presence of whereas the tuberin Dishevelled interaction was increased . Negative_regulation AXIN2 WNT3 16303557 1485411 We further demonstrate that depletion of Galpha ( o ) or Galpha ( q ) will inhibit , respectively , the *induced* disruption of [GSK3beta/Axin2] and GSK3beta/Axin complexes and diminish Wnt stabilization of beta-catenin . Negative_regulation AXIN2 WNT3 16303557 1485470 We conclude that rapid disruption of [GSK3beta/Axin] interactions in *response* to leads to the initial stabilization of beta-catenin and that Galpha ( o ) and Galpha ( q ) signaling contributes to Wnt mediated GSK3beta/Axin disruption and the ultimate stabilization of beta-catenin . Negative_regulation AXIN2 WNT3 19888210 2161358 We show that Ube2m interacts with and modulates beta-catenin stability , and that the antagonistic effect of Nkd1 on signaling *requires* interaction with [Axin] , itself a negative pathway regulator . Negative_regulation AXIN2 WNT3A 19464575 2084975 PCB 153 reduced basal [Axin2] mRNA levels and it *inhibited* induction of Axin2 expression by recombinant mouse . Negative_regulation AXIN2 WNT4 12781135 1095625 *induced* inhibition of the [Axin] complex depends on Dishevelled ( Dsh ) , a cytoplasmic protein that can bind to Axin , but the mechanism of this inhibition is not understood . Negative_regulation AXIN2 WNT4 15972957 1424306 Further , the interaction between TSC1/TSC2 and components of the beta-catenin degradation complex was dependent on Wnt stimulation such that binding of tuberin to GSK3 and [Axin] was reduced in the *presence* of whereas the tuberin Dishevelled interaction was increased . Negative_regulation AXIN2 WNT4 16303557 1485412 We further demonstrate that depletion of Galpha ( o ) or Galpha ( q ) will inhibit , respectively , the *induced* disruption of [GSK3beta/Axin2] and GSK3beta/Axin complexes and diminish Wnt stabilization of beta-catenin . Negative_regulation AXIN2 WNT4 16303557 1485471 We conclude that rapid disruption of [GSK3beta/Axin] interactions in *response* to leads to the initial stabilization of beta-catenin and that Galpha ( o ) and Galpha ( q ) signaling contributes to Wnt mediated GSK3beta/Axin disruption and the ultimate stabilization of beta-catenin . Negative_regulation AXIN2 WNT4 19888210 2161359 We show that Ube2m interacts with and modulates beta-catenin stability , and that the antagonistic effect of Nkd1 on signaling *requires* interaction with [Axin] , itself a negative pathway regulator . Negative_regulation AXIN2 WNT6 12781135 1095626 induced *inhibition* of the [Axin] complex depends on Dishevelled ( Dsh ) , a cytoplasmic protein that can bind to Axin , but the mechanism of this inhibition is not understood . Negative_regulation AXIN2 WNT6 15972957 1424307 Further , the interaction between TSC1/TSC2 and components of the beta-catenin degradation complex was dependent on Wnt stimulation such that binding of tuberin to GSK3 and [Axin] was *reduced* in the presence of whereas the tuberin Dishevelled interaction was increased . Negative_regulation AXIN2 WNT6 16303557 1485413 We further demonstrate that depletion of Galpha ( o ) or Galpha ( q ) will inhibit , respectively , the *induced* disruption of [GSK3beta/Axin2] and GSK3beta/Axin complexes and diminish Wnt stabilization of beta-catenin . Negative_regulation AXIN2 WNT6 16303557 1485472 We conclude that rapid disruption of [GSK3beta/Axin] interactions in *response* to leads to the initial stabilization of beta-catenin and that Galpha ( o ) and Galpha ( q ) signaling contributes to Wnt mediated GSK3beta/Axin disruption and the ultimate stabilization of beta-catenin . Negative_regulation AXIN2 WNT6 19888210 2161360 We show that Ube2m interacts with and modulates beta-catenin stability , and that the antagonistic effect of Nkd1 on signaling *requires* interaction with [Axin] , itself a negative pathway regulator . Negative_regulation B3GAT3 IL1B 15601778 1348170 We previously reported that *down-regulated* the expression and activity of [GlcAT-I] in primary rat chondrocytes . Negative_regulation B4GALT1 TNF 17917074 1804095 The *role* of and its receptors in the production of [beta-1,4 galactosyltransferase I] and V mRNAs by rat primary astrocytes . Negative_regulation B9D2 TNF 22025632 2508075 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation BACE1 CAPN8 20595388 2309368 Consistently , overexpression of in heterologous APP expressing cells *up-regulated* the level of [BACE1] and increased Abeta production . Negative_regulation BACE1 PGC 21358044 2463484 In contrast , down-regulation of levels by transfection with PGC-1a siRNA *increased* [BACE1] expression . Negative_regulation BAD TNF 12023375 943784 Thus , [BAD1] of B. dermatitidis *induces* suppression of and progressive infection by both TGF-beta dependent and -independent mechanisms . Negative_regulation BAIAP2 KANK4 19171758 2027761 specifically *inhibits* the binding of [IRSp53] with active Rac1 ( Rac1 ( G12V ) ) but not Cdc42 ( cdc42 ( G12V ) ) and thus inhibits the IRSp53 dependent development of lamellipodia without affecting the formation of filopodia . Negative_regulation BAMBI TNF 24448807 2932990 We investigated the mechanism by which TLR4 signaling down-regulates BAMBI expression in HSCs and found that TLR4- and *mediated* [BAMBI] down-regulation is dependent on regulation of BAMBI promoter activity through the interaction with NF-?Bp50 and HDAC1 in HSCs . Negative_regulation BAMBI TNF 24448807 2932991 In human HSCs , [BAMBI] expression was down-regulated in *response* to LPS and . Negative_regulation BAX ANGPT1 23554782 2714259 Specifically , *prevented* DOX induced increases in FasL and [Bax] levels and cleaved caspase-3 and caspase-8 levels in H9C2 cells . Negative_regulation BAX CAPN8 16214879 1508040 U-46619 induced activation *resulted* in translocation of [Bax] to the mitochondria , loss of polarization of the latter ( using potentiometric probe 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolyl-carbocyanine iodide ; Negative_regulation BAX CAPN8 18468506 1921553 We found that inhibition of *increased* oridonin induced [Bax] activation , cytochrome c release and PARP cleavage , indicating that calpain plays an anti-apoptotic role in oridonin induced L929 cell apoptosis . Negative_regulation BAX CCND1 19153211 2079262 In vivo , azacitidine ( 0.8 mg/kg i.p. ) reduced tumor proliferation and induced apoptosis in both xenografts upmodulating the expression of p16INKA , [Bax] , Bak , p21/WAF1 , and p27/KIP1 , and *inhibiting* the activation of Akt activity and the expression of , Bcl-2 , and Bcl-XL . Negative_regulation BAX CCND1 19471891 2085389 NF-kappaB target gene expression of apoptotic cell death proteins ( [Bax] , caspase-3 , caspase-9 ) was significantly enhanced , but the expression of anti-apoptotic genes and cell proliferation marker genes ( Bcl-2 , inhibitor of apoptosis protein ( IAP-1 ) and X chromosome IAP (XIAP) , Cox-2 , c-Fos , c-Jun and ) was significantly *inhibited* by the combined treatment compared to Rg3 or docetaxel alone . Negative_regulation BAX CCND1 21209944 2359476 In xenografted tumors , resveratrol upregulated the expressions of TRAIL-R1/DR4 , TRAIL-R2/DR5 , [Bax] and p27 ( /KIP1 ) , and *inhibited* the expression of Bcl-2 and . Negative_regulation BAX CCND1 23708661 2926310 IL-6 promoted NPC cell proliferation in a dose- and time dependent manner , accompanied by increasing and Bcl-2 expression and the Stat3 activation , but *inhibiting* [Bax] and p21 expression . Negative_regulation BAX EGLN3 20849813 2331327 Furthermore , immunoprecipitation experiments showed that upregulation *reduced* the formation of the [Bax-Bcl-2] complex , inhibiting the anti-apoptotic effect of Bcl-2 . Negative_regulation BAX EPHB2 15790513 1386369 Inhibiting activation *reduced* the increased expression of p27 and [Bax] , but had no effect on the decreased expression of Bcl-2 , suggesting the involvement of ERK activation in the SN-induced increased expression of p27 and Bax . Negative_regulation BAX EPHB2 17298978 1698949 Inhibition of *prevented* the DADLE induced decrease in apoptosis and [Bax] translocation , and increase in survivin and Bcl-2 . Negative_regulation BAX FAS 12529377 1079126 In human KB epithelial cells expressing the caspase-resistant mutant crBAP31 , stimulation resulted in cleavage of BID and insertion of BAX into mitochondrial membrane , but subsequent oligomerization of [BAX] and BAK , egress of cytochrome c to the cytosol , and apoptosis were *impaired* . Negative_regulation BAX ID1 18158619 1971449 expression *resulted* in increased number of viable cells , reduced [Bax] expression , enhanced Bcl-2 expression , but no change in Bcl-xL expression . Negative_regulation BAX MAP2K6 11842081 929172 In contrast , both U0126 , a inhibitor , and active MEK *had* little effect on [Bax] localization . Negative_regulation BAX MMP28 19513559 2092537 The WEPN treatment *induced* the upregulation of pro-apoptotic [Bax] , downregulation of anti-apoptotic Bcl-2 expression and loss of mitochondrial , which was associated with the proteolytic activation of caspases and the concomitant degradation of poly ( ADP ribose ) polymerase ( PARP ) protein . Negative_regulation BAX MMP7 19513559 2092552 The WEPN treatment *induced* the upregulation of pro-apoptotic [Bax] , downregulation of anti-apoptotic Bcl-2 expression and loss of mitochondrial , which was associated with the proteolytic activation of caspases and the concomitant degradation of poly ( ADP ribose ) polymerase ( PARP ) protein . Negative_regulation BAX PECAM1 12649141 1099404 In addition , markedly *suppressed* [Bax] overexpression induced cytochrome c release , caspase activation , and nuclear fragmentation . Negative_regulation BAX TNF 11571294 882328 induces E1B 19K-Bax interaction and *inhibits* [Bax] oligomerization . Negative_regulation BCHE ALOX5 23380204 2758975 The strongest <5-lipoxygenase (5-LOX)> , acetylcholinesterase (AChE) and [butyrylcholinesterase (BuChE)] *inhibition* activities were obtained for the ethanol extract ( IC50 values of 6.20 , 14.83 and 2.65mg/l , respectively ) and the best cytotoxic activity against MCF-7 cells was obtained for the methanol extract ( IC50=31mg/l ) . Negative_regulation BCHE FAS 18155347 1875163 Taken collectively , these results suggest that chlorpyrifos induces apoptosis in placental cells through pathways not dependent on signaling , activation of caspases or *inhibition* of [cholinesterase] . Negative_regulation BCHE TNF 18155347 1875162 Taken collectively , these results suggest that chlorpyrifos induces apoptosis in placental cells through pathways not dependent on signaling , activation of caspases or *inhibition* of [cholinesterase] . Negative_regulation BCL10 ARSA 15546508 1338101 Both and indomethacin *reduced* the protein levels of Bcl-2 and [Bcl-xl] , but upregulated those of Bax and Bcl-xs . Negative_regulation BCL10 FAS 21786383 2803027 Western blot analysis demonstrated that propofol promoted , cytochrome c , caspase-9 and -3 active form and Bax levels , but *inhibited* [Bcl-xl] protein level which led to cell apoptosis . Negative_regulation BCL10 FAS 9317114 456232 In this system , ligation also *triggers* [Bcl-2/Bcl-x] down-regulation , an effect inhibited by sIgG cross linking , the cysteine protease inhibitor acetyl-Tyr-Val-Ala-Asp-chloromethyl ketone , and PMA treatment . Negative_regulation BCL10 FOXO1 20228261 2254430 IGF-1 prevents ANG II-induced skeletal muscle atrophy via Akt- and dependent *inhibition* of the [ubiquitin ligase] atrogin-1 expression . Negative_regulation BCL10 ID1 18158619 1971450 expression *resulted* in increased number of viable cells , reduced Bax expression , enhanced Bcl-2 expression , but no change in [Bcl-xL] expression . Negative_regulation BCL10 TLR7 24384074 2900126 *led* to a down-regulation of MARCH1 [ubiquitin ligase] which prevents the degradation of MHC-II and decreased IL-10 also contributed to an increase in MHC-II . Negative_regulation BCL10 TNF 16243830 1471160 Further investigation showed that silencing of hPEBP4 in MCF-7 cells promoted *induced* stability of p53 , up-regulation of phospho-p53ser15 , p21waf/cip , and Bax , and down-regulation of Bcl-2 and [Bcl-xL] , which were shown to depend on extracellular signal regulated kinase 1/2 and c-jun NH2-terminal kinase activation by hPEBP4 silencing . Negative_regulation BCL10 TNF 18591962 1966113 However , [Bcl-x] ( L ) protein levels , but not those of Bcl-2 , Bax and Bak , are *reduced* by ActD or treatments . Negative_regulation BCL10 TNF 18838114 1988235 DXMb protects the organ of Corti against TNFalpha ototoxicity by up-regulating Bcl-2 and [Bcl-xl] expression and by *inhibiting* induced increases in Bax , TNFR1 , and the Bax/Bcl-2 ratio . Negative_regulation BCL10 TNF 19411063 2070945 Wu et al. , in this issue of Cancer Cell , show that dependent NFkappaB activation *induces* COP9 signalosome mediated inhibition of GSK3beta and the SCF(beta-TRCP) [ubiquitin ligase] , thus leading to stabilization of the transcription factor Snail and promoting cell migration and metastasis . Negative_regulation BCL10 TNFSF10 18457369 1909364 In addition , Clematis mandshurica treatment prevents the *induced* reduction of the interactions between 14-3-3 with phospho-ser112-Bad and phospho-ser136-Bad , and [BcL-xL] with phospho-ser155-Bad . Negative_regulation BCL10 TNFSF10 21554547 2475625 *induced* a decrease in Bid , Bcl-2 and [Bcl-xL] protein levels , increase in cleaved Bid and Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 and -3 ) and an increase in the tumour suppressor p53 levels . Negative_regulation BCL10 TNFSF10 21800052 2521523 *induced* a decrease in Bid , Bcl-2 , [Bcl-xL] , and survivin protein levels , increase in Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 , and -3 ) , cleavage of PARP-1 and an increase in the tumor suppressor p53 levels . Negative_regulation BCL2 ARSA 15546508 1338102 Both and indomethacin *reduced* the protein levels of Bcl-2 and [Bcl-xl] , but upregulated those of Bax and Bcl-xs . Negative_regulation BCL2 CAPN8 19782128 2264327 Nuclear translocation and *dependent* reduction of [Bcl-2] after neonatal cerebral hypoxia-ischemia . Negative_regulation BCL2 CTGF 10601320 574562 Finally , recombinant showed no effect on Bax protein expression but significantly *reduced* [Bcl2] protein expression . Negative_regulation BCL2 EGLN3 20849813 2331328 Furthermore , immunoprecipitation experiments showed that upregulation *reduced* the formation of the [Bax-Bcl-2] complex , inhibiting the anti-apoptotic effect of Bcl-2 . Negative_regulation BCL2 EPHB2 10097113 601585 By contrast , neither an inhibitor ( PD098059 ) nor p38 inhibitors ( SB203580 and SB202190 ) *had* an effect on [Bcl-2] phosphorylation . Negative_regulation BCL2 EPHB2 23741975 2909188 Combined treatment with rapamycin and IDA down-regulated [Bcl-2] and Mcl-1 , and *inhibited* the activation of phosphoinositide 3-kinase (PI3K)/mTOR and extracellular signal related kinase ( ) . Negative_regulation BCL2 FAS 16120269 895996 Using a stable transfected CEM cell line , we show that [Bcl-2] suppressed caspase processing in both cytosolic and mitochondrial compartments in *response* to both staurosporine and ligation . Negative_regulation BCL2 FAS 20179890 2215934 As shown in our preliminary study , MCP-1 induced apoptosis of hUVECs in a dose dependent manner at both 24 h and 48 h. FACS and Western blot analysis results in the present study indicated that MCP-1 promoted the expression of proapoptotic proteins Bax and and *inhibited* the expression of antiapoptotic protein [Bcl-2] . Negative_regulation BCL2 FAS 21190961 2378979 BCL-6 decreased and inducible nitric oxide synthase expression and nitric oxide production , but it *inhibited* the expression of the antiapoptotic proteins [Bcl-2] and JunB while increasing the expression of the proapoptotic death protein 5 . Negative_regulation BCL2 FAS 21786383 2803030 Western blot analysis demonstrated that propofol promoted , cytochrome c , caspase-9 and -3 active form and Bax levels , but *inhibited* [Bcl-xl] protein level which led to cell apoptosis . Negative_regulation BCL2 FAS 22528224 2589581 In addition , disruption of ??m was followed by up-regulated expression of pro-apoptotic Bax , and Fas-L , and *down-regulated* expression of anti-apoptotic [Bcl-2] . Negative_regulation BCL2 FAS 24983900 2947846 FX induced the up-regulation of Bax , Trp53 and Casp9 and *down-regulated* [Bcl2] but the expression levels of and Casp8 mRNA remained unchanged . Negative_regulation BCL2 FAS 9317114 456233 In this system , ligation also *triggers* [Bcl-2/Bcl-x] down-regulation , an effect inhibited by sIgG cross linking , the cysteine protease inhibitor acetyl-Tyr-Val-Ala-Asp-chloromethyl ketone , and PMA treatment . Negative_regulation BCL2 FAS 9317114 456234 In A20 cells , signaling may thus *trigger* both ICE activation and Bcl-x and [Bcl-2] down-regulation . Negative_regulation BCL2 FAS 9764613 537369 MoAb induced apoptosis of RA synovial cells in vitro , and proinflammatory cytokines tumour necrosis factor-alpha (TNF-alpha) and IL-1beta , but not IL-6 or IL-8 , *inhibited* the anti-Fas induced apoptosis accompanying up-regulation of [Bcl-2] protein expression and reduced expression of CPP32 and ICH-1L . Negative_regulation BCL2 FAS 9823951 549032 These results suggest that some pediatric ALL cells expressing mt-p53+ may be sensitive to *mediated* apoptosis due to high levels of Fas expression and lack of [Bcl-2] , and further suggest that molecular methods of activating Fas may be useful for therapy of refractory ALL with the Fas+/mt-p53+ phenotype . Negative_regulation BCL2 ID1 18158619 1971451 expression *resulted* in increased number of viable cells , reduced Bax expression , enhanced Bcl-2 expression , but no change in [Bcl-xL] expression . Negative_regulation BCL2 MAOA 22065207 2567961 The novel *role* of in [Bcl-2] induction by rasagiline is discussed with regard to the molecular mechanism underlying neuroprotection by the MAO inhibitors . Negative_regulation BCL2 MAP2K6 18512759 1951964 NAC reversed the A beta ( 25-35 ) -induced decrease in the expression of [Bcl-2] , which could be *blocked* by the MAPK kinase ( ) inhibitor or Cdk5 inhibitors . Negative_regulation BCL2 TNF 11704864 879393 Here we show that an increase in the level of expression of [Bcl-2] in the human prostate carcinoma cell line LNCaP observed in response to hormone withdrawal is further *augmented* by treatment , and this effect is abated by inhibitors of NF-kappa B . Negative_regulation BCL2 TNF 11805237 906403 In conclusion , cilostazol and its analogs exert a strong protection against apoptotic cell death by scavenging hydroxyl radicals and intracellular ROS with reduction in formation and by *increasing* [Bcl-2] protein expression and decreasing Bax protein and cytochrome c release . Negative_regulation BCL2 TNF 12054739 951469 dramatically *reduced* intracellular levels of [Bcl-2] , while Dex abrogated this reduction . Negative_regulation BCL2 TNF 12077131 976076 We observed no detectable changes in the steady-state levels of Bcl-X ( L ) , Bax , and Bid , although *suppresses* [Bcl-2] expression . Negative_regulation BCL2 TNF 14667973 1178041 Treatment with P4 augmented EGF and [Bcl-2] protein expression , but *inhibited* IGF-I and expression in cultured leiomyoma cells . Negative_regulation BCL2 TNF 15317679 1286345 Additional studies suggested that the *induced* decrease in [Bcl-2] expression and activation of the intrinsic mitochondrial death pathway were responsible for the cardiac myocyte apoptosis observed in the MHCsTNF mice . Negative_regulation BCL2 TNF 16243830 1471161 Further investigation showed that silencing of hPEBP4 in MCF-7 cells promoted *induced* stability of p53 , up-regulation of phospho-p53ser15 , p21waf/cip , and Bax , and down-regulation of Bcl-2 and [Bcl-xL] , which were shown to depend on extracellular signal regulated kinase 1/2 and c-jun NH2-terminal kinase activation by hPEBP4 silencing . Negative_regulation BCL2 TNF 18838114 1988238 DXMb protects the organ of Corti against TNFalpha ototoxicity by up-regulating Bcl-2 and [Bcl-xl] expression and by *inhibiting* induced increases in Bax , TNFR1 , and the Bax/Bcl-2 ratio . Negative_regulation BCL2 TNF 9581775 503479 plus NAC treatment *resulted* in a marked decrease in [Bcl-2] protein levels in HIV-1 infected cells , coupled with an increase in Bax protein compared to uninfected cells , suggesting that the difference in susceptibility to TNFalpha induced apoptosis may relate to the differences in relative levels of Bcl-2 and Bax . Negative_regulation BCL2 TNF 9581775 503485 As was observed for the U9-IIIB cells , treatment also *induced* a marked decrease in [Bcl-2] protein levels in TD-IkappaB expressing cells . Negative_regulation BCL2 TNFSF10 17534449 1746715 We explored the combined therapeutic effects of a secretable form of ( S ) *induced* apoptosis and the downregulation of [Bcl-2] in human gliomas . Negative_regulation BCL2 TNFSF10 17534449 1746718 These results show that simultaneous triggering of *mediated* death receptor pathway and downregulation of [Bcl-2] by shRNA leads to enhanced eradication of gliomas and serves as a template in developing and monitoring combination therapies for the treatment of drug-resistant cancers . Negative_regulation BCL2 TNFSF10 18457369 1909365 In addition , Clematis mandshurica treatment prevents the *induced* reduction of the interactions between 14-3-3 with phospho-ser112-Bad and phospho-ser136-Bad , and [BcL-xL] with phospho-ser155-Bad . Negative_regulation BCL2 TNFSF10 21554547 2475626 *induced* a decrease in Bid , Bcl-2 and [Bcl-xL] protein levels , increase in cleaved Bid and Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 and -3 ) and an increase in the tumour suppressor p53 levels . Negative_regulation BCL2 TNFSF10 21800052 2521524 *induced* a decrease in Bid , Bcl-2 , [Bcl-xL] , and survivin protein levels , increase in Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 , and -3 ) , cleavage of PARP-1 and an increase in the tumor suppressor p53 levels . Negative_regulation BCL2 TP63 21527555 2449133 *Repression* of proapoptotic [Bcl-2] family member genes including p53 upregulated modulator of apoptosis ( PUMA ) by is required for survival of SCC cells . Negative_regulation BCL2L1 TNFSF10 18497982 1917532 *reduced* endogenous TRAIL , [Bcl2l1] and caspase-1 expression . Negative_regulation BCL2L11 FOXO1 19553561 2128953 activation *resulted* in a significant increase in muscle atrophy F-box (MAFbx)/atrogin-1 , muscle-specific RING finger protein 1 ( MuRF-1 ) , and [Bcl-2 interacting mediator of cell death] ( Bim ) gene expression , with no significant increase in Bcl-2/adenovirus E1B 19-kDa interacting protein 3 ( BNip3 ) gene expression . Negative_regulation BCL3 ARSA 15546508 1338103 Both and indomethacin *reduced* the protein levels of Bcl-2 and [Bcl-xl] , but upregulated those of Bax and Bcl-xs . Negative_regulation BCL3 FAS 21786383 2803033 Western blot analysis demonstrated that propofol promoted , cytochrome c , caspase-9 and -3 active form and Bax levels , but *inhibited* [Bcl-xl] protein level which led to cell apoptosis . Negative_regulation BCL3 ID1 18158619 1971452 expression *resulted* in increased number of viable cells , reduced Bax expression , enhanced Bcl-2 expression , but no change in [Bcl-xL] expression . Negative_regulation BCL3 TNF 16243830 1471162 Further investigation showed that silencing of hPEBP4 in MCF-7 cells promoted *induced* stability of p53 , up-regulation of phospho-p53ser15 , p21waf/cip , and Bax , and down-regulation of Bcl-2 and [Bcl-xL] , which were shown to depend on extracellular signal regulated kinase 1/2 and c-jun NH2-terminal kinase activation by hPEBP4 silencing . Negative_regulation BCL3 TNF 18838114 1988241 DXMb protects the organ of Corti against TNFalpha ototoxicity by up-regulating Bcl-2 and [Bcl-xl] expression and by *inhibiting* induced increases in Bax , TNFR1 , and the Bax/Bcl-2 ratio . Negative_regulation BCL3 TNFSF10 18457369 1909366 In addition , Clematis mandshurica treatment prevents the *induced* reduction of the interactions between 14-3-3 with phospho-ser112-Bad and phospho-ser136-Bad , and [BcL-xL] with phospho-ser155-Bad . Negative_regulation BCL3 TNFSF10 21554547 2475627 *induced* a decrease in Bid , Bcl-2 and [Bcl-xL] protein levels , increase in cleaved Bid and Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 and -3 ) and an increase in the tumour suppressor p53 levels . Negative_regulation BCL3 TNFSF10 21800052 2521525 *induced* a decrease in Bid , Bcl-2 , [Bcl-xL] , and survivin protein levels , increase in Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 , and -3 ) , cleavage of PARP-1 and an increase in the tumor suppressor p53 levels . Negative_regulation BCL5 ARSA 15546508 1338098 Both and indomethacin *reduced* the protein levels of Bcl-2 and [Bcl-xl] , but upregulated those of Bax and Bcl-xs . Negative_regulation BCL5 FAS 21786383 2803000 Western blot analysis demonstrated that propofol promoted , cytochrome c , caspase-9 and -3 active form and Bax levels , but *inhibited* [Bcl-xl] protein level which led to cell apoptosis . Negative_regulation BCL5 ID1 18158619 1971446 expression *resulted* in increased number of viable cells , reduced Bax expression , enhanced Bcl-2 expression , but no change in [Bcl-xL] expression . Negative_regulation BCL5 TNF 16243830 1471154 Further investigation showed that silencing of hPEBP4 in MCF-7 cells promoted *induced* stability of p53 , up-regulation of phospho-p53ser15 , p21waf/cip , and Bax , and down-regulation of Bcl-2 and [Bcl-xL] , which were shown to depend on extracellular signal regulated kinase 1/2 and c-jun NH2-terminal kinase activation by hPEBP4 silencing . Negative_regulation BCL5 TNF 18838114 1988214 DXMb protects the organ of Corti against TNFalpha ototoxicity by up-regulating Bcl-2 and [Bcl-xl] expression and by *inhibiting* induced increases in Bax , TNFR1 , and the Bax/Bcl-2 ratio . Negative_regulation BCL5 TNFSF10 18457369 1909361 In addition , Clematis mandshurica treatment prevents the *induced* reduction of the interactions between 14-3-3 with phospho-ser112-Bad and phospho-ser136-Bad , and [BcL-xL] with phospho-ser155-Bad . Negative_regulation BCL5 TNFSF10 21554547 2475616 *induced* a decrease in Bid , Bcl-2 and [Bcl-xL] protein levels , increase in cleaved Bid and Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 and -3 ) and an increase in the tumour suppressor p53 levels . Negative_regulation BCL5 TNFSF10 21800052 2521514 *induced* a decrease in Bid , Bcl-2 , [Bcl-xL] , and survivin protein levels , increase in Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 , and -3 ) , cleavage of PARP-1 and an increase in the tumor suppressor p53 levels . Negative_regulation BCL6 ARSA 15546508 1338099 Both and indomethacin *reduced* the protein levels of Bcl-2 and [Bcl-xl] , but upregulated those of Bax and Bcl-xs . Negative_regulation BCL6 FAS 21786383 2803003 Western blot analysis demonstrated that propofol promoted , cytochrome c , caspase-9 and -3 active form and Bax levels , but *inhibited* [Bcl-xl] protein level which led to cell apoptosis . Negative_regulation BCL6 ID1 18158619 1971447 expression *resulted* in increased number of viable cells , reduced Bax expression , enhanced Bcl-2 expression , but no change in [Bcl-xL] expression . Negative_regulation BCL6 TNF 16243830 1471155 Further investigation showed that silencing of hPEBP4 in MCF-7 cells promoted *induced* stability of p53 , up-regulation of phospho-p53ser15 , p21waf/cip , and Bax , and down-regulation of Bcl-2 and [Bcl-xL] , which were shown to depend on extracellular signal regulated kinase 1/2 and c-jun NH2-terminal kinase activation by hPEBP4 silencing . Negative_regulation BCL6 TNF 18838114 1988217 DXMb protects the organ of Corti against TNFalpha ototoxicity by up-regulating Bcl-2 and [Bcl-xl] expression and by *inhibiting* induced increases in Bax , TNFR1 , and the Bax/Bcl-2 ratio . Negative_regulation BCL6 TNFSF10 18457369 1909362 In addition , Clematis mandshurica treatment prevents the *induced* reduction of the interactions between 14-3-3 with phospho-ser112-Bad and phospho-ser136-Bad , and [BcL-xL] with phospho-ser155-Bad . Negative_regulation BCL6 TNFSF10 21554547 2475617 *induced* a decrease in Bid , Bcl-2 and [Bcl-xL] protein levels , increase in cleaved Bid and Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 and -3 ) and an increase in the tumour suppressor p53 levels . Negative_regulation BCL6 TNFSF10 21800052 2521515 *induced* a decrease in Bid , Bcl-2 , [Bcl-xL] , and survivin protein levels , increase in Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 , and -3 ) , cleavage of PARP-1 and an increase in the tumor suppressor p53 levels . Negative_regulation BCL9 ARSA 15546508 1338100 Both and indomethacin *reduced* the protein levels of Bcl-2 and [Bcl-xl] , but upregulated those of Bax and Bcl-xs . Negative_regulation BCL9 FAS 21786383 2803006 Western blot analysis demonstrated that propofol promoted , cytochrome c , caspase-9 and -3 active form and Bax levels , but *inhibited* [Bcl-xl] protein level which led to cell apoptosis . Negative_regulation BCL9 ID1 18158619 1971448 expression *resulted* in increased number of viable cells , reduced Bax expression , enhanced Bcl-2 expression , but no change in [Bcl-xL] expression . Negative_regulation BCL9 TNF 16243830 1471156 Further investigation showed that silencing of hPEBP4 in MCF-7 cells promoted *induced* stability of p53 , up-regulation of phospho-p53ser15 , p21waf/cip , and Bax , and down-regulation of Bcl-2 and [Bcl-xL] , which were shown to depend on extracellular signal regulated kinase 1/2 and c-jun NH2-terminal kinase activation by hPEBP4 silencing . Negative_regulation BCL9 TNF 18838114 1988220 DXMb protects the organ of Corti against TNFalpha ototoxicity by up-regulating Bcl-2 and [Bcl-xl] expression and by *inhibiting* induced increases in Bax , TNFR1 , and the Bax/Bcl-2 ratio . Negative_regulation BCL9 TNFSF10 18457369 1909363 In addition , Clematis mandshurica treatment prevents the *induced* reduction of the interactions between 14-3-3 with phospho-ser112-Bad and phospho-ser136-Bad , and [BcL-xL] with phospho-ser155-Bad . Negative_regulation BCL9 TNFSF10 21554547 2475618 *induced* a decrease in Bid , Bcl-2 and [Bcl-xL] protein levels , increase in cleaved Bid and Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 and -3 ) and an increase in the tumour suppressor p53 levels . Negative_regulation BCL9 TNFSF10 21800052 2521516 *induced* a decrease in Bid , Bcl-2 , [Bcl-xL] , and survivin protein levels , increase in Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 , and -3 ) , cleavage of PARP-1 and an increase in the tumor suppressor p53 levels . Negative_regulation BCR CD22 12055217 951719 Moreover , in CD22-deficient mice , anti-IgM treatment did not trigger enhanced Ca ( 2+ ) influx in CD5 ( + ) B-1 cells , unlike CD22-deficient splenic B-2 cells , suggesting a relatively limited *role* of in [BCR] signaling in B-1 cells . Negative_regulation BCR CD22 23456653 2760566 Epratuzumab is a humanized monoclonal antibody that targets CD22 on B cells and results in modulation of B-cell function and migration , as regulates adhesion and *inhibits* [B-cell receptor (BCR)] signalling . Negative_regulation BCR EPHB2 18048365 1861115 [BCR] activation results in the induction of c-Fos , FosB , and JunB , and expression of these are *suppressed* by and JNK inhibitors . Negative_regulation BCRP1 TNF 19629677 2195027 [BCRP] mRNA levels were significantly *reduced* by IL-1beta , IL-6 and . Negative_regulation BCRP1 TNF 19629677 2195045 IL-1beta , IL-6 and also significantly *reduced* the [BCRP] activity as assessed by mitoxantrone uptake experiments . Negative_regulation BCRP2 TNF 19629677 2195019 [BCRP] mRNA levels were significantly *reduced* by IL-1beta , IL-6 and . Negative_regulation BCRP2 TNF 19629677 2195037 IL-1beta , IL-6 and also significantly *reduced* the [BCRP] activity as assessed by mitoxantrone uptake experiments . Negative_regulation BCRP3 TNF 19629677 2195021 [BCRP] mRNA levels were significantly *reduced* by IL-1beta , IL-6 and . Negative_regulation BCRP3 TNF 19629677 2195039 IL-1beta , IL-6 and also significantly *reduced* the [BCRP] activity as assessed by mitoxantrone uptake experiments . Negative_regulation BCRP4 TNF 19629677 2195023 [BCRP] mRNA levels were significantly *reduced* by IL-1beta , IL-6 and . Negative_regulation BCRP4 TNF 19629677 2195041 IL-1beta , IL-6 and also significantly *reduced* the [BCRP] activity as assessed by mitoxantrone uptake experiments . Negative_regulation BCRP5 TNF 19629677 2195025 [BCRP] mRNA levels were significantly *reduced* by IL-1beta , IL-6 and . Negative_regulation BCRP5 TNF 19629677 2195043 IL-1beta , IL-6 and also significantly *reduced* the [BCRP] activity as assessed by mitoxantrone uptake experiments . Negative_regulation BCRP6 TNF 19629677 2195029 [BCRP] mRNA levels were significantly *reduced* by IL-1beta , IL-6 and . Negative_regulation BCRP6 TNF 19629677 2195047 IL-1beta , IL-6 and also significantly *reduced* the [BCRP] activity as assessed by mitoxantrone uptake experiments . Negative_regulation BCRP7 TNF 19629677 2195031 [BCRP] mRNA levels were significantly *reduced* by IL-1beta , IL-6 and . Negative_regulation BCRP7 TNF 19629677 2195049 IL-1beta , IL-6 and also significantly *reduced* the [BCRP] activity as assessed by mitoxantrone uptake experiments . Negative_regulation BCRP8 TNF 19629677 2195033 [BCRP] mRNA levels were significantly *reduced* by IL-1beta , IL-6 and . Negative_regulation BCRP8 TNF 19629677 2195051 IL-1beta , IL-6 and also significantly *reduced* the [BCRP] activity as assessed by mitoxantrone uptake experiments . Negative_regulation BCRP9 TNF 19629677 2195035 [BCRP] mRNA levels were significantly *reduced* by IL-1beta , IL-6 and . Negative_regulation BCRP9 TNF 19629677 2195053 IL-1beta , IL-6 and also significantly *reduced* the [BCRP] activity as assessed by mitoxantrone uptake experiments . Negative_regulation BDKRB2 EPHB2 22818222 2640047 Inhibiting activation *blocked* IL-1ß induced [BDKRB2] mRNA expression while increasing COX-2 expression . Negative_regulation BDNF EPHB2 14684879 1179334 We also show that activation of extracellular signal regulated kinase ( Erk ) by [BDNF] is required to overcome inhibition by MAG , and that activated transiently *inhibits* phosphodiesterase 4 ( PDE4 ) , the enzyme that hydrolyzes cAMP . Negative_regulation BDNF EPHB2 16269011 1502326 Blocking activation with PD98059 or U0126 *prevented* the FGF-2 induced up-regulation of [BDNF] transcription but had no effect on TrkB . Negative_regulation BDNF TNF 12182839 977886 In contrast , [BDNF] expression was *reduced* by in human umbilical vein endothelial cells ( HUVEC ) . Negative_regulation BDNF TNF 14654461 1188358 Moreover , lack of *increased* the expression of nerve growth factor (NGF) , but not [brain derived neurotrophic factor (BDNF)] , following performance of the learning task . Negative_regulation BECN1 TLR7 18772134 1985780 signaling enhances the interaction of MyD88 and Trif with Beclin 1 , and *reduces* the binding of [Beclin 1] to Bcl-2 . Negative_regulation BECN1 TLR7 18772134 1985810 These findings indicate signaling via its adaptor proteins *reduces* the binding of [Beclin 1] to Bcl-2 by recruiting Beclin 1 into the TLR signaling complex leading to autophagy . Negative_regulation BGLAP CTGF 18583340 1946713 Overexpression of in ST-2 cells *increased* alkaline phosphatase activity , [osteocalcin] and alkaline phosphatase mRNA levels , and mineralized nodule formation . Negative_regulation BGLAP FOXO1 21471200 2433551 We showed that *inhibited* Runx2 dependent transcriptional activity and osteocalcin mRNA expression and [Bglap2] promoter activity in MC-4 preosteoblasts . Negative_regulation BGLAP IL1B 11934644 927812 and ( iv ) reverses *dependent* suppression of [osteocalcin] and alkaline phosphatase synthesis . Negative_regulation BGLAP IL1B 1309841 178453 In the present studies , and TNF-alpha both *inhibited* 1,25-dihydroxyvitamin D3-stimulated production of [osteocalcin] protein and mRNA by ROS 17/2.8 osteosarcoma cells , whereas IL-6 had no effect on protein and only weakly inhibited mRNA . Negative_regulation BGLAP IL1B 16774854 1631522 Furthermore , in addition to down regulating BMP-2 induced Smad1/5 phosphorylation , also *caused* a reduction in the level of BMP-2 induced alkaline phosphatase activity and [osteocalcin] expression , both closely associated with bone cell differentiation . Negative_regulation BGLAP IL1B 20460758 2257487 stimulated cellular proliferation but *inhibited* the synthesis of [osteocalcin] containing gamma carboxylated glutamic acid ( Gla-OSCAL ) . Negative_regulation BGLAP TNF 1309841 178452 In the present studies , IL-1 beta and both *inhibited* 1,25-dihydroxyvitamin D3-stimulated production of [osteocalcin] protein and mRNA by ROS 17/2.8 osteosarcoma cells , whereas IL-6 had no effect on protein and only weakly inhibited mRNA . Negative_regulation BGLAP TNF 1309841 178454 In screening studies , ( -57 % ) and IL-6 ( -37 % ) *inhibited* vitamin D-stimulated [osteocalcin] transcription , whereas IL-1 alpha , IL-1 beta , and IL-8 had no effect . Negative_regulation BGLAP TNF 16813528 1580732 At the injured growth plate on day 8 , inhibition *increased* expression of cbfa1 and [osteocalcin] and increased trabecular bone formation at the injury site . Negative_regulation BGLAP TNF 2019266 157115 *inhibits* 1,25-dihydroxyvitamin D3-stimulated [bone Gla protein] synthesis in rat osteosarcoma cells ( ROS 17/2.8 ) by a pretranslational mechanism . Negative_regulation BGLAP TNF 2019266 157117 ( 10 ng/ml ) *inhibited* [BGP] secretion to 42 +/- 5 % , 19 +/- 10 % , and 15 +/- 3 % of control values after 24 , 48 , and 72 h of treatment . Negative_regulation BGLAP TNF 2019266 157120 These results suggest that the mechanism of *inhibition* of [BGP] synthesis includes a pretranslational site and support the hypothesis that TNF alpha inhibits bone formation by a selective inhibition of matrix protein production . Negative_regulation BGLAP TNF 20638987 2292237 In addition , *suppressed* BMP-2 induced Runx2 and [osteocalcin] expression , and estradiol and dexamethasone reversed the TNF-alpha effects on BMP-2 induced Runx2 expression . Negative_regulation BGLAP TNF 8119149 250593 We have shown that *inhibition* of 1,25-dihydroxyvitamin D3 [ 1,25- ( OH ) 2D3 ] -stimulated synthesis of the bone-specific protein [osteocalcin (OC)] occurs by decreasing steady state levels of OC mRNA , suggesting a pretranslational mechanism . Negative_regulation BGLAP TNF 8213262 231537 We have previously shown that *inhibits* 1,25- ( OH ) 2D3 stimulated synthesis of [bone gla protein (BGP)] , an abundant and osteoblast-specific matrix constituent . Negative_regulation BGLAP TNF 8891757 392025 In the present study , the importance of prostaglandin formation in IL-1 and induced *inhibition* of [osteocalcin] and type I collagen formation has been examined . Negative_regulation BGLAP TNF 8891757 392038 Four non-steroidal antiinflammatory drugs , indomethacin , flurbiprofen , naproxen and meclofenamic acid , inhibited basal , IL-1 beta- and TNF-alpha stimulated PGE2 formation in the MG-63 cells without affecting IL-1 beta- or induced *inhibition* of [osteocalcin] and type I collagen formation . Negative_regulation BGLAP TNF 8891757 392042 These data show that IL-1 and *inhibit* [osteocalcin] and type I collagen formation in osteoblasts independently of prostaglandin biosynthesis and that non-steroidal antiinflammatory drugs do not affect the effects of IL-1 and TNF on bone matrix biosynthesis . Negative_regulation BGN IL1B 7490271 335480 decorin was only slightly up-regulated by IL-1 beta , while [biglycan] was markedly *down-regulated* by and significantly up-regulated by TGF-beta 1 . Negative_regulation BGN TNF 9139731 428240 that changed the morphology of the cells from a polygonal shape into a spindle shape and that also *stimulated* the detachment of the cells from culture dish , markedly decreased the net synthesis of [biglycan] , whereas the net synthesis of PG-100 was increased . Negative_regulation BID FAS 12529377 1079123 In human KB epithelial cells expressing the caspase-resistant mutant crBAP31 , stimulation *resulted* in cleavage of [BID] and insertion of BAX into mitochondrial membrane , but subsequent oligomerization of BAX and BAK , egress of cytochrome c to the cytosol , and apoptosis were impaired . Negative_regulation BIRC2 IL1B 11373338 817854 In mesangial cells , and tumor necrosis factor-alpha *induced* cellular inhibitor of apoptosis 1 ( [cIAP1] ) mRNA expression within 3 h . Negative_regulation BIRC2 TNF 11373338 817853 In mesangial cells , interleukin-1beta (IL-1beta) and *induced* cellular inhibitor of apoptosis 1 ( [cIAP1] ) mRNA expression within 3 h . Negative_regulation BIRC2 TNFSF10 20951133 2365020 *induced* loss of [cIAP-1] and XIAP requires caspase activity . Negative_regulation BIRC3 EPHB2 20403072 2282201 inhibition at the initial stage of I/R injury may *cause* changes in c-IAP2 gene expression or [c-IAP2/caspase] 3 interactions , resulting in long lasting therapeutic effects . Negative_regulation BIRC3 MAP2K6 20403072 2282207 inhibition at the initial stage of I/R injury may *cause* changes in c-IAP2 gene expression or [c-IAP2/caspase] 3 interactions , resulting in long lasting therapeutic effects . Negative_regulation BMP1 CTGF 12134160 968966 These results show that *inhibits* [BMP] and activates TGF-beta signals by direct binding in the extracellular space . Negative_regulation BMP1 CTGF 16769906 1572575 Edar activation also induces , an *inhibitor* of [BMP] signaling , allowing BMP action only at a distance from their site of synthesis . Negative_regulation BMP1 CTGF 17164417 1679049 Using a quantitative approach , we show in cultured embryonic skin that Eda induced the expression of two [Bmp] *inhibitors* , ( CCN family protein 2/connective tissue growth factor ) and follistatin . Negative_regulation BMP1 HES2 16616763 1598371 130/0.4 can *inhibit* CLP induced [PCP] by attenuating pulmonary inflammation and NF-kappaB activation in vivo . Negative_regulation BMP1 MAP2K6 15019950 1221031 Real-time PCR showed that neither [BMP] stimulation nor *inhibition* increased Trk receptor expression and that the BMP induced genes Smad6 and Id1 were not upregulated by PD98059 . Negative_regulation BMP1 TNF 16373342 1519759 *inhibited* the expression of [bone morphogenetic protein] and transforming growth factor-beta signaling reporter constructs , and the inhibition of each was blocked by Smurf1 siRNA and Smurf2 siRNA , respectively . Negative_regulation BMP1 TNF 19854828 2170367 These results suggest that *inhibits* [BMP] signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB . Negative_regulation BMP10 CTGF 12134160 968974 These results show that *inhibits* [BMP] and activates TGF-beta signals by direct binding in the extracellular space . Negative_regulation BMP10 CTGF 16769906 1572591 Edar activation also induces , an *inhibitor* of [BMP] signaling , allowing BMP action only at a distance from their site of synthesis . Negative_regulation BMP10 CTGF 17164417 1679065 Using a quantitative approach , we show in cultured embryonic skin that Eda induced the expression of two [Bmp] *inhibitors* , ( CCN family protein 2/connective tissue growth factor ) and follistatin . Negative_regulation BMP10 MAP2K6 15019950 1221087 Real-time PCR showed that neither [BMP] stimulation nor *inhibition* increased Trk receptor expression and that the BMP induced genes Smad6 and Id1 were not upregulated by PD98059 . Negative_regulation BMP10 TNF 16373342 1519767 *inhibited* the expression of [bone morphogenetic protein] and transforming growth factor-beta signaling reporter constructs , and the inhibition of each was blocked by Smurf1 siRNA and Smurf2 siRNA , respectively . Negative_regulation BMP10 TNF 19854828 2170375 These results suggest that *inhibits* [BMP] signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB . Negative_regulation BMP15 CTGF 12134160 968967 These results show that *inhibits* [BMP] and activates TGF-beta signals by direct binding in the extracellular space . Negative_regulation BMP15 CTGF 16769906 1572577 Edar activation also induces , an *inhibitor* of [BMP] signaling , allowing BMP action only at a distance from their site of synthesis . Negative_regulation BMP15 CTGF 17164417 1679051 Using a quantitative approach , we show in cultured embryonic skin that Eda induced the expression of two [Bmp] *inhibitors* , ( CCN family protein 2/connective tissue growth factor ) and follistatin . Negative_regulation BMP15 MAP2K6 15019950 1221038 Real-time PCR showed that neither [BMP] stimulation nor *inhibition* increased Trk receptor expression and that the BMP induced genes Smad6 and Id1 were not upregulated by PD98059 . Negative_regulation BMP15 TNF 16373342 1519760 *inhibited* the expression of [bone morphogenetic protein] and transforming growth factor-beta signaling reporter constructs , and the inhibition of each was blocked by Smurf1 siRNA and Smurf2 siRNA , respectively . Negative_regulation BMP15 TNF 19854828 2170368 These results suggest that *inhibits* [BMP] signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB . Negative_regulation BMP2 CTGF 12134160 968968 These results show that *inhibits* [BMP] and activates TGF-beta signals by direct binding in the extracellular space . Negative_regulation BMP2 CTGF 16769906 1572579 Edar activation also induces , an *inhibitor* of [BMP] signaling , allowing BMP action only at a distance from their site of synthesis . Negative_regulation BMP2 CTGF 17164417 1679053 Using a quantitative approach , we show in cultured embryonic skin that Eda induced the expression of two [Bmp] *inhibitors* , ( CCN family protein 2/connective tissue growth factor ) and follistatin . Negative_regulation BMP2 KLF9 20410205 2274289 Loss of in mice and HESCs *enhanced* [BMP2] expression , whereas recombinant BMP2 treatment of HESCs attenuated KLF9 mRNA levels . Negative_regulation BMP2 MAP2K6 15019950 1221045 Real-time PCR showed that neither [BMP] stimulation nor *inhibition* increased Trk receptor expression and that the BMP induced genes Smad6 and Id1 were not upregulated by PD98059 . Negative_regulation BMP2 TNF 16373342 1519761 *inhibited* the expression of [bone morphogenetic protein] and transforming growth factor-beta signaling reporter constructs , and the inhibition of each was blocked by Smurf1 siRNA and Smurf2 siRNA , respectively . Negative_regulation BMP2 TNF 17266397 1725627 In vitro , *suppresses* [BMP-2-] and TGFbeta mediated Smad activation through induction of NF-kappaB . Negative_regulation BMP2 TNF 19854828 2170339 In this study , we found that inhibited the alkaline phosphatase activity and markedly *reduced* [BMP2-] and Smad induced reporter activity in MC3T3-E1 cells . Negative_regulation BMP2 TNF 19854828 2170369 These results suggest that *inhibits* [BMP] signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB . Negative_regulation BMP2 TNF 22179526 2575009 inhibition in diabetic animals also reduced apoptosis , increased proliferation of bone lining cells , and *increased* mRNA levels of FGF-2 , TGFß-1 , [BMP-2] , and BMP-6 . Negative_regulation BMP2 TNF 25228904 2958354 However , IL-17 decreased the *induced* [BMP2] inhibition . Negative_regulation BMP3 CTGF 12134160 968969 These results show that *inhibits* [BMP] and activates TGF-beta signals by direct binding in the extracellular space . Negative_regulation BMP3 CTGF 16769906 1572581 Edar activation also induces , an *inhibitor* of [BMP] signaling , allowing BMP action only at a distance from their site of synthesis . Negative_regulation BMP3 CTGF 17164417 1679055 Using a quantitative approach , we show in cultured embryonic skin that Eda induced the expression of two [Bmp] *inhibitors* , ( CCN family protein 2/connective tissue growth factor ) and follistatin . Negative_regulation BMP3 MAP2K6 15019950 1221052 Real-time PCR showed that neither [BMP] stimulation nor *inhibition* increased Trk receptor expression and that the BMP induced genes Smad6 and Id1 were not upregulated by PD98059 . Negative_regulation BMP3 TNF 16373342 1519762 *inhibited* the expression of [bone morphogenetic protein] and transforming growth factor-beta signaling reporter constructs , and the inhibition of each was blocked by Smurf1 siRNA and Smurf2 siRNA , respectively . Negative_regulation BMP3 TNF 19854828 2170370 These results suggest that *inhibits* [BMP] signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB . Negative_regulation BMP4 CTGF 12134160 968970 These results show that *inhibits* [BMP] and activates TGF-beta signals by direct binding in the extracellular space . Negative_regulation BMP4 CTGF 16769906 1572583 Edar activation also induces , an *inhibitor* of [BMP] signaling , allowing BMP action only at a distance from their site of synthesis . Negative_regulation BMP4 CTGF 17164417 1679057 Using a quantitative approach , we show in cultured embryonic skin that Eda induced the expression of two [Bmp] *inhibitors* , ( CCN family protein 2/connective tissue growth factor ) and follistatin . Negative_regulation BMP4 FOXO1 15688035 1376232 [BMP4] expression , for example , was *repressed* by both Pax3 and in SaOS-2 cells , while in the rhabdomyosarcoma , RD , Pax3/FKHR , but not Pax3 , induced BMP4 expression . Negative_regulation BMP4 IL1B 9874511 557155 [BMP-4] was *down-regulated* by IFN-alpha ( approximately 60 % ) and ( approximately 20 % ) . Negative_regulation BMP4 MAP2K6 15019950 1221059 Real-time PCR showed that neither [BMP] stimulation nor *inhibition* increased Trk receptor expression and that the BMP induced genes Smad6 and Id1 were not upregulated by PD98059 . Negative_regulation BMP4 MSX1 21297014 2388337 We also found that by itself *represses* transcription from this proximal [Bmp4] promoter , and that , in combination with Pax9 , it acts as a potentiator of Pax9 induced Bmp4 transactivation . Negative_regulation BMP4 NR2F1 7499338 332922 By co-transfection of a COUP-TFI expression plasmid with the BMP-4 1A promoter in fetal rat calvarial osteoblasts , we demonstrated that *inhibits* the [BMP-4] promoter activity . Negative_regulation BMP4 OSR1 22791896 2634590 Our data suggest that normally *repress* [bmp4] expression in the lpm , and that BMP signaling negatively regulates the wnt2b domain . Negative_regulation BMP4 PLAU 17275810 1704340 Overexpression of [BMP-4] changed cell morphology to invasive spindle phenotype and *induced* the expression and activity of . Negative_regulation BMP4 TNF 16373342 1519763 *inhibited* the expression of [bone morphogenetic protein] and transforming growth factor-beta signaling reporter constructs , and the inhibition of each was blocked by Smurf1 siRNA and Smurf2 siRNA , respectively . Negative_regulation BMP4 TNF 19854828 2170371 These results suggest that *inhibits* [BMP] signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB . Negative_regulation BMP5 CTGF 12134160 968971 These results show that *inhibits* [BMP] and activates TGF-beta signals by direct binding in the extracellular space . Negative_regulation BMP5 CTGF 16769906 1572585 Edar activation also induces , an *inhibitor* of [BMP] signaling , allowing BMP action only at a distance from their site of synthesis . Negative_regulation BMP5 CTGF 17164417 1679059 Using a quantitative approach , we show in cultured embryonic skin that Eda induced the expression of two [Bmp] *inhibitors* , ( CCN family protein 2/connective tissue growth factor ) and follistatin . Negative_regulation BMP5 MAP2K6 15019950 1221066 Real-time PCR showed that neither [BMP] stimulation nor *inhibition* increased Trk receptor expression and that the BMP induced genes Smad6 and Id1 were not upregulated by PD98059 . Negative_regulation BMP5 TNF 16373342 1519764 *inhibited* the expression of [bone morphogenetic protein] and transforming growth factor-beta signaling reporter constructs , and the inhibition of each was blocked by Smurf1 siRNA and Smurf2 siRNA , respectively . Negative_regulation BMP5 TNF 19854828 2170372 These results suggest that *inhibits* [BMP] signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB . Negative_regulation BMP5 TNF 21319131 2469718 Stimulation of HK-2 cells with TGF-ß , and AT-II *resulted* in a significant decreased expression of [BMP-5] and its receptors . Negative_regulation BMP6 CTGF 12134160 968972 These results show that *inhibits* [BMP] and activates TGF-beta signals by direct binding in the extracellular space . Negative_regulation BMP6 CTGF 16769906 1572587 Edar activation also induces , an *inhibitor* of [BMP] signaling , allowing BMP action only at a distance from their site of synthesis . Negative_regulation BMP6 CTGF 17164417 1679061 Using a quantitative approach , we show in cultured embryonic skin that Eda induced the expression of two [Bmp] *inhibitors* , ( CCN family protein 2/connective tissue growth factor ) and follistatin . Negative_regulation BMP6 ETV7 11108721 786494 The retinoic acid receptor alpha and [bone morphogenetic protein-6B (BMP-6)] genes are specifically *repressed* by indicating a function for Tel-2 as an inhibitor of differentiation . Negative_regulation BMP6 MAP2K6 15019950 1221073 Real-time PCR showed that neither [BMP] stimulation nor *inhibition* increased Trk receptor expression and that the BMP induced genes Smad6 and Id1 were not upregulated by PD98059 . Negative_regulation BMP6 TNF 16373342 1519765 *inhibited* the expression of [bone morphogenetic protein] and transforming growth factor-beta signaling reporter constructs , and the inhibition of each was blocked by Smurf1 siRNA and Smurf2 siRNA , respectively . Negative_regulation BMP6 TNF 19854828 2170373 These results suggest that *inhibits* [BMP] signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB . Negative_regulation BMP6 TNF 22179526 2575010 inhibition in diabetic animals also reduced apoptosis , increased proliferation of bone lining cells , and *increased* mRNA levels of FGF-2 , TGFß-1 , BMP-2 , and [BMP-6] . Negative_regulation BMP7 CHRDL1 19357253 2064871 We propose that *reduces* [BMP7] signaling in healthy proximal tubules , and the loss of this activity upon sloughing of injured epithelia promotes BMP7 signaling in repopulating , dedifferentiated epithelia . Negative_regulation BMP7 CTGF 12134160 968973 These results show that *inhibits* [BMP] and activates TGF-beta signals by direct binding in the extracellular space . Negative_regulation BMP7 CTGF 16769906 1572589 Edar activation also induces , an *inhibitor* of [BMP] signaling , allowing BMP action only at a distance from their site of synthesis . Negative_regulation BMP7 CTGF 17164417 1679063 Using a quantitative approach , we show in cultured embryonic skin that Eda induced the expression of two [Bmp] *inhibitors* , ( CCN family protein 2/connective tissue growth factor ) and follistatin . Negative_regulation BMP7 CTGF 18632843 1979293 *inhibits* [BMP-7] signaling in diabetic nephropathy . Negative_regulation BMP7 CTGF 18632843 1979304 In cultured renal glomerular and tubulointerstitial cells , *diminished* [BMP-7] signaling activity , evidenced by lower levels of pSmad1/5 , Id1 mRNA , and BMP-responsive element-luciferase activity . Negative_regulation BMP7 MAP2K6 15019950 1221080 Real-time PCR showed that neither [BMP] stimulation nor *inhibition* increased Trk receptor expression and that the BMP induced genes Smad6 and Id1 were not upregulated by PD98059 . Negative_regulation BMP7 MMP7 22215634 2559034 ( MMP-7 ) *inhibition* of [BMP-7] induced renal tubular branching morphogenesis suggests a role in the pathogenesis of human renal dysplasia . Negative_regulation BMP7 TNF 16373342 1519766 *inhibited* the expression of [bone morphogenetic protein] and transforming growth factor-beta signaling reporter constructs , and the inhibition of each was blocked by Smurf1 siRNA and Smurf2 siRNA , respectively . Negative_regulation BMP7 TNF 18816401 1993554 in the cartilage , however , blocking of *increased* the expression of [BMP7] . Negative_regulation BMP7 TNF 19854828 2170374 These results suggest that *inhibits* [BMP] signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB . Negative_regulation BMPR2 TNF 16797218 1579073 The results showed that although *down-regulated* [BMPR-IA and -II] transcripts , it increased the level of BMPR-IB mRNA via a MAPK dependent pathway . Negative_regulation BNIP3 CAPN8 22525374 2658629 Inhibition of the mPTP pore with BH4-TAT peptide , *inhibition* with PD150606 , or knockdown ( KD ) of [Bnip3] failed to prevent nuclear translocation of these DNase although Bnip3 KD blocked mitochondrial fission . Negative_regulation BNIP3 FOXO1 22102632 2557427 Expression of DN *inhibited* the increased mRNA levels of atrogin-1 , MuRF1 , cathepsin L , and/or [Bnip3] and inhibited muscle fiber atrophy during cancer cachexia and sepsis . Negative_regulation BPI CEBPE 17483073 1738808 In this study , we studied the *role* of a myeloid-specific transcription factor , ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Negative_regulation BPI SP1 16282362 1518462 Studies of BPI promoter expression in IECs identified regulatory regions of the BPI promoter and revealed a prominent *role* for CCAAT/enhancer binding protein and especially in the basal regulation of [BPI] . Negative_regulation BPI SP3 16282362 1518463 Studies of BPI promoter expression in IECs identified regulatory regions of the BPI promoter and revealed a prominent *role* for CCAAT/enhancer binding protein and especially in the basal regulation of [BPI] . Negative_regulation BPI TCF12 17483073 1738800 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Negative_regulation BPI TCF15 17483073 1738801 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Negative_regulation BPI TCF19 17483073 1738802 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Negative_regulation BPI TCF20 17483073 1738803 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Negative_regulation BPI TCF21 17483073 1738804 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Negative_regulation BPI TCF23 17483073 1738809 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Negative_regulation BPI TCF24 17483073 1738811 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Negative_regulation BPI TCF25 17483073 1738810 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Negative_regulation BPI TCF3 17483073 1738805 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Negative_regulation BPI TCF4 17483073 1738806 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Negative_regulation BPI TCF7 17483073 1738807 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Negative_regulation BPI TNF 8648149 363678 To assess the *role* of in the elevated [BPI] levels during sepsis , the following studies were performed . Negative_regulation BPNT1 TNF 8170501 255191 As the *induced* decrease of [PIP2] synthesis was associated with a decreased synthesis of the phospholipid phosphatidylinositol ( PI ) , the precursor of PIP2 , by 33 % , the decreased availability of PIP2 is apparently , at least in part , the result of the decreased synthesis of PI . Negative_regulation BRAF EPHB2 20810616 2341714 We found that nanomolar concentrations of Sorafenib reduced the basal activity of , *inhibited* cAMP dependent activation of [B-Raf] and MEK/ERK signaling , and caused a concentration dependent inhibition of cell proliferation induced by cAMP , epidermal growth factor , or the combination of the two agonists . Negative_regulation BRAF EPHB2 22206679 2537592 Here , we showed that although UI-152 inhibited , it *induced* [B-Raf] binding to Raf-1 as well as Raf-1 activation . Negative_regulation BRAF MAP2K6 12364324 1019024 GLP1 stimulated activation of Erk is blocked by inhibitors of , but GLP1 does not *induce* the activation of A-Raf , [B-Raf] , C-Raf , or Ras . Negative_regulation BRAF MAP2K6 18045987 1861080 The expression of Rnd3 , a Rho antagonist , was attenuated after [B-RAF] knockdown or *inhibition* , but it was enhanced in melanocytes expressing active B-RAF . Negative_regulation BRAF MAP2K6 20629085 2334845 Understanding network of signal-transduction pathways and how that network may adapt to [BRAF] inhibition or *inhibition* will point to the next generation of clinical trials investigating rational combination regimens . Negative_regulation BRAF MAP2K6 22437314 2612748 These alterations uniformly promoted MAPK reactivation and most conferred resistance to inhibition and to the concurrent *inhibition* of [BRAF] and MEK . Negative_regulation BRAF MAP2K6 24132923 2878965 Characterization included expression profiling , assessment of MEK signature and compensatory pathways , *inhibition* , [BRAF] expression , and cytokine levels . Negative_regulation BRAF MAP2K6 24345920 2880920 Activation of the mitogen activated protein kinase (MAPK) pathway in cells by ectopic expression of PAPSS1-BRAF was abrogated by ( MEK ) inhibition but not by [BRAF] *inhibition* . Negative_regulation BRCA1 CCND1 17334399 1772002 Using chromatin immunoprecipitation assays , we observed that the inhibition of activity *resulted* in increased [BRCA1] DNA binding at particular promoters in vivo . Negative_regulation BSG MMP28 14985463 1214883 Increased activity in tumor local environment *results* in proteolytic cleavage of membrane associated [EMMPRIN] , releasing soluble EMMPRIN . Negative_regulation BSG MMP7 14985463 1214898 Increased activity in tumor local environment *results* in proteolytic cleavage of membrane associated [EMMPRIN] , releasing soluble EMMPRIN . Negative_regulation BTG1 ARSA 2763271 116506 AD6 ( 20-50 mumols/l ) , but not , incubated with whole blood or PRP , *prevented* the fall in platelet count and the release of [BTG] for at least 150 min . Negative_regulation BTG1 ARSA 2949396 66707 *caused* a significant reduction of [B-TG] plasma levels in TIA patients 2 hours after the first administration , but no effect was observed at the 7th and 14th day of treatment . Negative_regulation BTG1 ARSA 2961218 81228 At low PAF concentrations aggregation and [BTG] release were *blocked* by apyrase ( a scavenger of ADP ) , by ( an inhibitor of cyclooxygenase ) and by BM 13177 ( a thromboxane receptor antagonist ) . Negative_regulation BTG2 ARSA 2763271 116507 AD6 ( 20-50 mumols/l ) , but not , incubated with whole blood or PRP , *prevented* the fall in platelet count and the release of [BTG] for at least 150 min . Negative_regulation BTG2 ARSA 2949396 66708 *caused* a significant reduction of [B-TG] plasma levels in TIA patients 2 hours after the first administration , but no effect was observed at the 7th and 14th day of treatment . Negative_regulation BTG2 ARSA 2961218 81229 At low PAF concentrations aggregation and [BTG] release were *blocked* by apyrase ( a scavenger of ADP ) , by ( an inhibitor of cyclooxygenase ) and by BM 13177 ( a thromboxane receptor antagonist ) . Negative_regulation BTG3 ARSA 2763271 116508 AD6 ( 20-50 mumols/l ) , but not , incubated with whole blood or PRP , *prevented* the fall in platelet count and the release of [BTG] for at least 150 min . Negative_regulation BTG3 ARSA 2949396 66709 *caused* a significant reduction of [B-TG] plasma levels in TIA patients 2 hours after the first administration , but no effect was observed at the 7th and 14th day of treatment . Negative_regulation BTG3 ARSA 2961218 81230 At low PAF concentrations aggregation and [BTG] release were *blocked* by apyrase ( a scavenger of ADP ) , by ( an inhibitor of cyclooxygenase ) and by BM 13177 ( a thromboxane receptor antagonist ) . Negative_regulation BTG4 ARSA 2763271 116509 AD6 ( 20-50 mumols/l ) , but not , incubated with whole blood or PRP , *prevented* the fall in platelet count and the release of [BTG] for at least 150 min . Negative_regulation BTG4 ARSA 2949396 66710 *caused* a significant reduction of [B-TG] plasma levels in TIA patients 2 hours after the first administration , but no effect was observed at the 7th and 14th day of treatment . Negative_regulation BTG4 ARSA 2961218 81231 At low PAF concentrations aggregation and [BTG] release were *blocked* by apyrase ( a scavenger of ADP ) , by ( an inhibitor of cyclooxygenase ) and by BM 13177 ( a thromboxane receptor antagonist ) . Negative_regulation BTRC FGD3 18363964 1887896 Here we show that , which was identified as a homologue of FGD1 but has been poorly characterized , has conserved the same motif and is *down-regulated* similarly by [SCF] ( FWD1/beta-TrCP ) . Negative_regulation BTRC IL1B 15735017 1378392 In PancTu-1 cells , betaTRCP1 expression is inhibited , at least in part , by the interleukin-1 (IL-1) receptor ( I ) antagonist , whereas stimulation of PT45-P1 cells with *resulted* in an increased expression of [betaTRCP1] , and transfection of this cell line with betaTRCP1 induced IL-1beta secretion in a NF-kappaB dependent fashion . Negative_regulation BUB1 TNF 22025632 2508059 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation C1orf228 IFI27 17702989 1788801 Furthermore , overexpression of *enhanced* LPS induced [IL-12p40] and IkappaB-zeta mRNA induction while Ifi202 AS RNA suppressed these in RAW 264.7 cells . Negative_regulation C1orf228 TLR7 22685319 2675984 Interestingly , despite expression of TLR mRNA on Kupffer cells , ligation of TLR4 , , and TLR9 *resulted* in a weak induction of IL-10 , low or undetectable levels of [IL-12p40] and TNF , and up-regulation of CD40 on the surface . Negative_regulation C1QTNF9 TNF 23212557 2718450 In H9c2 cells , ( TNF-a ) strongly *inhibited* [CTRP9] expression ( > 60 % ) , and significantly reduced peroxisome proliferator activated receptor-gamma ( PPAR? ) , a known transcription factor promoting adiponectin expression . Negative_regulation C3 FUT4 19608865 2112222 In vitro , *inhibited* local [C5a/C3a] production by antigen presenting cell-T-cell complexes and attenuated MOG ( 35-55 ) -specific Th1 and Th17 responses with little nonspecific cytotoxicity . Negative_regulation C3 FUT4 2019419 157156 In this study , we showed that the concentration of 4.5 X 10 ( -6 ) M of FUT-175 caused 50 % inhibition of C5 convertase activity of CVF , Bb in reactive hemolysis assays , and that 4.0 X 10 ( -6 ) M *caused* 50 % inhibition of the production of [C3a] and C5a generated by the C3/C5 convertase activity of CVF , Bb . Negative_regulation C3 SCIN 20654625 2310798 Previously , we have shown that binds C3b directly and competitively *inhibits* binding of human factor H and , to a lesser degree , that of factor B to [C3b] . Negative_regulation C3 TNF 23168409 2729757 Peroxisome proliferator activated receptor a positively regulates [complement C3] expression but *inhibits* a-mediated activation of C3 gene in mammalian hepatic derived cells . Negative_regulation C3AR1 TNF 15056381 1229968 *down-regulated* the [C3aR] . Negative_regulation C4A FUT4 2303313 127843 In human serum , *inhibited* C3a , [C4a] and C5a generation induced by heat aggregated IgG , zymosan and Cobra venom factor with IC50 values in the range of 3-43 microM depending on the stimulus and the fragments . Negative_regulation C5 CFI 2221580 142848 Smoke treated *inhibited* only 36 % of the [C5a-GcG] chemotactic activity . Negative_regulation C5 CFI 2313096 130121 was found to markedly *inhibit* the neutrophil chemotactic activity of partially purified [C5a] containing GcG ( p less than 0.01 ) . Negative_regulation C5 FUT4 19608865 2112233 In vitro , *inhibited* local [C5a/C3a] production by antigen presenting cell-T-cell complexes and attenuated MOG ( 35-55 ) -specific Th1 and Th17 responses with little nonspecific cytotoxicity . Negative_regulation C5 FUT4 2019419 157167 In this study , we showed that the concentration of 4.5 X 10 ( -6 ) M of FUT-175 caused 50 % inhibition of C5 convertase activity of CVF , Bb in reactive hemolysis assays , and that 4.0 X 10 ( -6 ) M *caused* 50 % inhibition of the production of C3a and [C5a] generated by the C3/C5 convertase activity of CVF , Bb . Negative_regulation C5 FUT4 2303313 127854 In human serum , *inhibited* C3a , C4a and [C5a] generation induced by heat aggregated IgG , zymosan and Cobra venom factor with IC50 values in the range of 3-43 microM depending on the stimulus and the fragments . Negative_regulation C5 FUT4 2793750 119689 FUT-175 did not modify heparin + protamine induced leukopenia , suggesting that incompletely *blocked* [C5a] production . Negative_regulation C5AR2 TLR7 21630250 2481083 Furthermore , activation *inhibited* [C5L2] expression upon C5a stimulation . Negative_regulation C5AR2 TNF 17068344 1654792 In HeLa cells , interferon-gamma and drastically *reduce* [C5L2] expression . Negative_regulation C9orf3 TNF 11693580 876588 Among several cytokines tested , only *inhibited* [apo] E secretion in basal conditions in CCF-STTG1 human astrocytoma cells . Negative_regulation C9orf3 TNF 11693580 876589 In the presence of 25-hydroxycholesterol , *reduced* [apo] E secretion by 80 % , while interleukins ( IL ) IL-1beta , IL-6 , and IL-2 had no significant effects . Negative_regulation CA1 MFI2 16111909 1454272 It includes serum transferrin , ovotransferrin , lactoferrin , , *inhibitor* of [carbonic anhydrase] , saxiphilin , the major yolk protein in sea urchins , the crayfish protein , pacifastin , and a protein from green algae . Negative_regulation CA1 TF 23258311 2757974 Throughout the evolution of vertebrates , transferrin members have diversified into distinct subfamilies including , ovotransferrin , lactoferrin , melanotransferrin , the *inhibitor* of [carbonic anhydrase] , pacifastin , and the major yolk protein in sea urchin . Negative_regulation CA10 MFI2 16111909 1454273 It includes serum transferrin , ovotransferrin , lactoferrin , , *inhibitor* of [carbonic anhydrase] , saxiphilin , the major yolk protein in sea urchins , the crayfish protein , pacifastin , and a protein from green algae . Negative_regulation CA10 TF 23258311 2757975 Throughout the evolution of vertebrates , transferrin members have diversified into distinct subfamilies including , ovotransferrin , lactoferrin , melanotransferrin , the *inhibitor* of [carbonic anhydrase] , pacifastin , and the major yolk protein in sea urchin . Negative_regulation CA11 MFI2 16111909 1454274 It includes serum transferrin , ovotransferrin , lactoferrin , , *inhibitor* of [carbonic anhydrase] , saxiphilin , the major yolk protein in sea urchins , the crayfish protein , pacifastin , and a protein from green algae . Negative_regulation CA11 TF 23258311 2757976 Throughout the evolution of vertebrates , transferrin members have diversified into distinct subfamilies including , ovotransferrin , lactoferrin , melanotransferrin , the *inhibitor* of [carbonic anhydrase] , pacifastin , and the major yolk protein in sea urchin . Negative_regulation CA12 ADCY1 233968 972 The inhibitory effect of PTH was ATP- , Mg++- , and K+-dependent and temperature dependent ; inactivation of PTH by heating at 100degreesC abolished the effect of PTH both to activate and to *inhibit* [carbonic anhydrase] . Negative_regulation CA12 ADCY1 233968 1232 Calcium 5 mM also partially abolished effects of PTH to activate and to *inhibit* [carbonic anhydrase] . Negative_regulation CA12 ADCY10 233968 971 The inhibitory effect of PTH was ATP- , Mg++- , and K+-dependent and temperature dependent ; inactivation of PTH by heating at 100degreesC abolished the effect of PTH both to activate and to *inhibit* [carbonic anhydrase] . Negative_regulation CA12 ADCY10 233968 1231 Calcium 5 mM also partially abolished effects of PTH to activate and to *inhibit* [carbonic anhydrase] . Negative_regulation CA12 ADCY2 233968 973 The inhibitory effect of PTH was ATP- , Mg++- , and K+-dependent and temperature dependent ; inactivation of PTH by heating at 100degreesC abolished the effect of PTH both to activate and to *inhibit* [carbonic anhydrase] . Negative_regulation CA12 ADCY2 233968 1233 Calcium 5 mM also partially abolished effects of PTH to activate and to *inhibit* [carbonic anhydrase] . Negative_regulation CA12 ADCY3 233968 974 The inhibitory effect of PTH was ATP- , Mg++- , and K+-dependent and temperature dependent ; inactivation of PTH by heating at 100degreesC abolished the effect of PTH both to activate and to *inhibit* [carbonic anhydrase] . Negative_regulation CA12 ADCY3 233968 1234 Calcium 5 mM also partially abolished effects of PTH to activate and to *inhibit* [carbonic anhydrase] . Negative_regulation CA12 ADCY4 233968 975 The inhibitory effect of PTH was ATP- , Mg++- , and K+-dependent and temperature dependent ; inactivation of PTH by heating at 100degreesC abolished the effect of PTH both to activate and to *inhibit* [carbonic anhydrase] . Negative_regulation CA12 ADCY4 233968 1235 Calcium 5 mM also partially abolished effects of PTH to activate and to *inhibit* [carbonic anhydrase] . Negative_regulation CA12 ADCY5 233968 976 The inhibitory effect of PTH was ATP- , Mg++- , and K+-dependent and temperature dependent ; inactivation of PTH by heating at 100degreesC abolished the effect of PTH both to activate and to *inhibit* [carbonic anhydrase] . Negative_regulation CA12 ADCY5 233968 1236 Calcium 5 mM also partially abolished effects of PTH to activate and to *inhibit* [carbonic anhydrase] . Negative_regulation CA12 ADCY6 233968 977 The inhibitory effect of PTH was ATP- , Mg++- , and K+-dependent and temperature dependent ; inactivation of PTH by heating at 100degreesC abolished the effect of PTH both to activate and to *inhibit* [carbonic anhydrase] . Negative_regulation CA12 ADCY6 233968 1237 Calcium 5 mM also partially abolished effects of PTH to activate and to *inhibit* [carbonic anhydrase] . Negative_regulation CA12 ADCY7 233968 978 The inhibitory effect of PTH was ATP- , Mg++- , and K+-dependent and temperature dependent ; inactivation of PTH by heating at 100degreesC abolished the effect of PTH both to activate and to *inhibit* [carbonic anhydrase] . Negative_regulation CA12 ADCY7 233968 1238 Calcium 5 mM also partially abolished effects of PTH to activate and to *inhibit* [carbonic anhydrase] . Negative_regulation CA12 ADCY8 233968 979 The inhibitory effect of PTH was ATP- , Mg++- , and K+-dependent and temperature dependent ; inactivation of PTH by heating at 100degreesC abolished the effect of PTH both to activate and to *inhibit* [carbonic anhydrase] . Negative_regulation CA12 ADCY8 233968 1239 Calcium 5 mM also partially abolished effects of PTH to activate and to *inhibit* [carbonic anhydrase] . Negative_regulation CA12 ADCY9 233968 980 The inhibitory effect of PTH was ATP- , Mg++- , and K+-dependent and temperature dependent ; inactivation of PTH by heating at 100degreesC abolished the effect of PTH both to activate and to *inhibit* [carbonic anhydrase] . Negative_regulation CA12 ADCY9 233968 1240 Calcium 5 mM also partially abolished effects of PTH to activate and to *inhibit* [carbonic anhydrase] . Negative_regulation CA12 ATP5O 6302706 27481 NB did not inhibit [carbonic anhydrase] in whole stomach homogenates of guinea pig , but did *inhibit* the potassium stimulated gastric microsomal . Negative_regulation CA12 CALCA 2396499 141344 The stimulated calcium efflux was completely inhibited by both 10 ng/ml salmon , a physiologic inhibitor of osteoclast activity , and 4 x 10 ( -4 ) M acetazolamide , a specific *inhibitor* of [carbonic anhydrase] , the enzyme necessary for substantial proton generation by osteoclasts . Negative_regulation CA12 CSF2 6403922 26773 In anaesthetized normocapnic dogs [ HCO-3 ] was increased to ca 33 mmol/l by perfusing the brain ventricles for 45 min with a mock CSF containing a high [ HCO-3 ] which in addition contained 2.5 mg/ml acetazolamide to *inhibit* central [carbonic anhydrase] . Negative_regulation CA12 DBI 6414310 31725 The present experiments employed in vivo microperfusion , microcalorimetry , and microelectrode techniques to determine the effects of luminal application of a dextran bound [carbonic anhydrase] *inhibitor* ( ) on bicarbonate reabsorptive rate ( JtCO2 ) and intraluminal pH in the rat proximal convoluted tubule . Negative_regulation CA12 DDT 5572900 262 Does *inhibit* [carbonic anhydrase] ? Negative_regulation CA12 DDT 5572900 275 This degree of inhibition suggests that may not *inhibit* [carbonic anhydrase] effectively at the usual concentrations found in tissue after exposure of organisms to DDT in the environment . Negative_regulation CA12 MFI2 16111909 1454275 It includes serum transferrin , ovotransferrin , lactoferrin , , *inhibitor* of [carbonic anhydrase] , saxiphilin , the major yolk protein in sea urchins , the crayfish protein , pacifastin , and a protein from green algae . Negative_regulation CA12 MT-CO2 15258031 1272380 The effects of indomethacin , breathing ( 3 % ) before and after indomethacin treatment , and [carbonic anhydrase] *inhibition* with or without indomethacin treatment were investigated . Negative_regulation CA12 MT-CO2 15258031 1272406 After indomethacin had been given , the rise in ONPO ( 2 ) caused by breathing and [carbonic anhydrase] *inhibition* was significantly reduced . Negative_regulation CA12 MT-CO2 15708831 1373244 [Carbonic anhydrase] inhibition reduces the removal of CO2 from the tissue and the accumulation *induces* vasodilatation resulting in increased blood flow and improved oxygen supply . Negative_regulation CA12 NCOA5 9482718 488062 Although , has *reduced* internal [carbonic anhydrase] activity , unexpectedly the level of Cah3 was similar to that of the wild-type , suggesting that the mutant accumulates an inactive Cah3 polypeptide . Negative_regulation CA12 NPPB 17562070 1798023 The extent of overacidification was decreased by acetazolamide ( a [carbonic anhydrase] *inhibitor* ) , bumetanide ( an inhibitor of Na+/K+/2Cl ( - ) cotransporter [ NKCC ] ) , and ( an inhibitor of Cl ( - ) channel ) . Negative_regulation CA12 NPPB 21425321 2438353 A significant increase of 29.1 and 24.3 % in Cu accumulation was observed after cell incubation with acetozalamide ( [carbonic anhydrase] *inhibitor* ) and ( Cl ( - ) channels blocker ) , respectively . Negative_regulation CA12 PDX1 15367896 1294872 Overexpression of in HPC cultures *stimulated* somatostatin , glucagon , and [carbonic anhydrase] expression but had no effect on insulin gene expression . Negative_regulation CA12 SCAI 8647347 358671 The heterocyclic sulfonamide [carbonic anhydrase] *inhibitor* ( ) 6-ethoxyzolamide ( ETZ ) caused a decrease ( 42+/-7 % of control , IC50 = 2.2+/-1.1 x 10 ( -7 ) M ) in the incorporation of [ 14C ] bicarbonate into several Krebs cycle intermediates in 3T3-F442A adipocytes . Negative_regulation CA12 SDS 12388401 1035090 Unlike CA IV , expressed [CA XII] activity was *inhibited* by 1 % , suggesting insufficient disulfide linkages to stabilize the molecule . Negative_regulation CA12 TF 23258311 2757977 Throughout the evolution of vertebrates , transferrin members have diversified into distinct subfamilies including , ovotransferrin , lactoferrin , melanotransferrin , the *inhibitor* of [carbonic anhydrase] , pacifastin , and the major yolk protein in sea urchin . Negative_regulation CA12 TPM1 12102678 962761 *inhibits* [carbonic anhydrase] , with metabolic acidosis as a possible side effect , although this has been reported in only two adult cases . Negative_regulation CA12 TPM1 12199733 982641 *inhibits* [carbonic anhydrase] , which may result in metabolic acidosis from decreased serum bicarbonate . Negative_regulation CA12 TPM1 8156972 253292 weakly *inhibited* erythrocyte [carbonic anhydrase (CA)] activity . Negative_regulation CA12 TPM2 12102678 962762 *inhibits* [carbonic anhydrase] , with metabolic acidosis as a possible side effect , although this has been reported in only two adult cases . Negative_regulation CA12 TPM2 12199733 982642 *inhibits* [carbonic anhydrase] , which may result in metabolic acidosis from decreased serum bicarbonate . Negative_regulation CA12 TPM2 8156972 253293 weakly *inhibited* erythrocyte [carbonic anhydrase (CA)] activity . Negative_regulation CA12 TPM3 12102678 962763 *inhibits* [carbonic anhydrase] , with metabolic acidosis as a possible side effect , although this has been reported in only two adult cases . Negative_regulation CA12 TPM3 12199733 982643 *inhibits* [carbonic anhydrase] , which may result in metabolic acidosis from decreased serum bicarbonate . Negative_regulation CA12 TPM3 8156972 253294 weakly *inhibited* erythrocyte [carbonic anhydrase (CA)] activity . Negative_regulation CA12 TPM4 12102678 962764 *inhibits* [carbonic anhydrase] , with metabolic acidosis as a possible side effect , although this has been reported in only two adult cases . Negative_regulation CA12 TPM4 12199733 982644 *inhibits* [carbonic anhydrase] , which may result in metabolic acidosis from decreased serum bicarbonate . Negative_regulation CA12 TPM4 8156972 253295 weakly *inhibited* erythrocyte [carbonic anhydrase (CA)] activity . Negative_regulation CA12 VHL 9770531 539137 Reintroduced wild-type strongly *inhibited* the overexpression of the [CA12] gene in the parental renal cell carcinoma cell lines . Negative_regulation CA13 MFI2 16111909 1454284 It includes serum transferrin , ovotransferrin , lactoferrin , , *inhibitor* of [carbonic anhydrase] , saxiphilin , the major yolk protein in sea urchins , the crayfish protein , pacifastin , and a protein from green algae . Negative_regulation CA13 TF 23258311 2757986 Throughout the evolution of vertebrates , transferrin members have diversified into distinct subfamilies including , ovotransferrin , lactoferrin , melanotransferrin , the *inhibitor* of [carbonic anhydrase] , pacifastin , and the major yolk protein in sea urchin . Negative_regulation CA14 MFI2 16111909 1454276 It includes serum transferrin , ovotransferrin , lactoferrin , , *inhibitor* of [carbonic anhydrase] , saxiphilin , the major yolk protein in sea urchins , the crayfish protein , pacifastin , and a protein from green algae . Negative_regulation CA14 TF 23258311 2757978 Throughout the evolution of vertebrates , transferrin members have diversified into distinct subfamilies including , ovotransferrin , lactoferrin , melanotransferrin , the *inhibitor* of [carbonic anhydrase] , pacifastin , and the major yolk protein in sea urchin . Negative_regulation CA2 ARSA 8196511 259189 at concentrations of 250 microM or less , which had little effect on succinate linked respiration , *impaired* [Ca2+] accumulation in liver mitochondria by causing an increase in Ca2+ release . Negative_regulation CA2 CABP4 2346670 134846 Regucalcin , a isolated from rat liver cytosol , *inhibited* [Ca2] ( + ) - and phospholipid dependent protein kinase ( protein kinase C ) activity in hepatic cytosol . Negative_regulation CA2 CAPN8 12937083 1151470 Both [Ca2+] depletion and *inhibition* protected the cytoskeleton from degradation , as assessed by immunohistological and ultrastructural analysis . Negative_regulation CA2 CD22 19594633 2105410 recruits the tyrosine phosphatase Src homology 2 domain containing phosphatase 1 ( SHP-1 ) to immunoreceptor tyrosine based inhibitory motifs ( ITIMs ) and *inhibits* B-cell receptor (BCR) induced [Ca2+] signaling on normal B cells . Negative_regulation CA2 EDN2 2674497 117773 induced rapid *increase* followed by a decrease in cytosolic [Ca2+] [ ( Ca2+ ] i ) and a slow increase in muscle tension in the vascular smooth muscle strip of rat carotid artery . Negative_regulation CA2 EDN2 9176228 433681 BQ-788 , an ETB antagonist , *inhibited* [[Ca2+] ] i responses to . Negative_regulation CA2 F2R 12114324 964034 In wt LECs , thrombin or agonist peptide ( TFLLRNPNDK-NH2 ) *resulted* in a prolonged [Ca2+] transient secondary to influx of Ca2+ . Negative_regulation CA2 F2R 12632022 1067921 In summary , [Ca(II)3] ( 3,5-DIPS ) 6 , a new calmodulin dependent nitric oxide synthase activator , decreases P-selectin expression of human platelets in *response* to activation . Negative_regulation CA2 F2R 16939417 1673109 Desensitization of and PAR-4 or pre-treatment with the PAR-1 and PAR-4 antagonists SCH 79797 and tcY-NH2 reduced Ca2+ mobilization induced by thrombin , and depletion of the DTS after desensitization or blockade of PAR-1 and PAR-4 *had* no significant effect on [Ca2+] release stimulated by thrombin through the GPIb-IX-V receptor . Negative_regulation CA2 F2R 21148289 2396213 , ATP , and PDGF receptor activation *resulted* in prominent nuclear [Ca 2+] signals . Negative_regulation CA2 F2R 8621721 360129 Consistent with the PAF receptor phosphorylation , both thrombin and peptide *inhibited* phosphoinositide hydrolysis , [Ca2+] mobilization , and degranulation stimulated by PAF . Negative_regulation CA2 FOLR1 11640901 872042 did not alter Ca2+ influx stimulated by brief applications of NMDA or glutamate during normoxia or hypoxia , but did *reduce* the increase in [ [Ca2+] ] i produced by 10 min of glutamate exposure during hypoxia . Negative_regulation CA2 HES2 10963542 727339 Although hydroxyethyl starch decreased Ca2+ in but not Ca2+ up , not only *prevented* the increase of [Ca2+] in and Ca2+ up but also inhibited hepatocyte oxidative injury . Negative_regulation CA2 HRH1 7556415 327667 The role of inositol 1,3,4,5-tetrakisphosphate in internal [Ca2+] mobilization *following* stimulation in DDT1 MF-2 cells . Negative_regulation CA2 IL1B 11936556 927948 Antipyretic drugs such as acetylsalicylic acid , dexamethasone , and lipocortin 5- ( 204-212 ) peptide counteract *induced* fever and abolish changes in [Ca2+] and PGE2 concentrations in CSF . Negative_regulation CA2 IL1B 7552306 327493 These results indicate that and LPS *inhibit* 5-HT2 receptor mediated [Ca2+] mobilization via pathways that include the activation of a tyrosine kinase and protein kinase C . Negative_regulation CA2 ITGAL 19542227 2116370 Using membrane vesicles expressing the mouse class I major histocompatibility complex , i.e. Ld plus costimulatory ligands , i.e . B7-1 and intercellular adhesion molecule-1 along with 2C T cell receptor transgenic T cells , we investigated the *roles* of CD28 and ( lymphocyte function associated antigen-1 ) in the activation of PLC-gamma1 and [Ca2+] signaling . Negative_regulation CA2 ITGB2 11867690 918074 Most importantly , [Ca(2)] ( + ) mobilization did not *induce* activation of PYK2 when the interaction was prevented with function blocking mAb , implying that the Ca(2) ( + ) -induced activation of PYK2 requires integrin engagement . Negative_regulation CA2 ITGB2 19542227 2116382 These results ensure the unique *role* of in T cell [Ca2+] signaling and reveal that LFA-1 dependent Ca2+ entry proceeds via a mechanism separate from store operated Ca2+ entry . Negative_regulation CA2 JAG1 2825594 80941 The Na+ , K+-ATPase from brain or kidney and sarcoplasmic reticulum ( SR ) [Ca2+-ATPase] were *inhibited* potently by agelasidine C ( Agd-C ) and , the bioactive principles of sea sponge , while Agd-C and Ags-B exerted less potent inhibition of heart Na+ , K+-ATPase . Negative_regulation CA2 MAP2K6 8954997 401124 Although inhibitor *had* no effect on oxytocin induced intracellular [Ca2+] mobilization in either pregnant human or pregnant rat uterine cells , it partly inhibited oxytocin induced pregnant rat uterine contraction in a dose dependent manner . Negative_regulation CA2 MFI2 16111909 1454277 It includes serum transferrin , ovotransferrin , lactoferrin , , *inhibitor* of [carbonic anhydrase] , saxiphilin , the major yolk protein in sea urchins , the crayfish protein , pacifastin , and a protein from green algae . Negative_regulation CA2 MMP28 18661233 2028069 Baicalein *induced* an increase in the cytoplasmic levels of ROS and [Ca2+] in 1 h and reached their peak at 3 h , and thereafter a loss of by flow cytometry . Negative_regulation CA2 MMP7 18661233 2028084 Baicalein induced an *increase* in the cytoplasmic levels of ROS and [Ca2+] in 1 h and reached their peak at 3 h , and thereafter a loss of by flow cytometry . Negative_regulation CA2 RGS2 12975484 1151796 Potentiated [Ca2+] signaling by CXCR2 was markedly *attenuated* by expression of either or the Gbetagamma-scavenger Galphat1 ( transducin alpha subunit ) , indicating the involvement of Galphaq and Gbetagamma subunits , respectively . Negative_regulation CA2 RGS2 15383626 1334867 In HEK293 cells , stable expression of myc tagged , -3 , or -4 at equivalent levels also *inhibited* phosphoinositide and [Ca2+] signaling by endogenously expressed muscarinic M3 receptors in the order RGS3 > or = RGS2 > RGS4 . Negative_regulation CA2 SELL 7518434 261857 The *role* of in ROI production and [Ca2+] signaling in suspended neutrophils was examined using the DREG series of anti-L-selectin antibodies . Negative_regulation CA2 SELL 8600168 351822 However , ATP induced loss of did not *require* extracellular [Ca2+] . Negative_regulation CA2 SPHK1 9020156 412648 However , in CG4 cells block of did not *increase* the oscillatory [Ca2+] response elicited by PDGF-BB , although the addition of exogenous sphingosine induced an oscillatory Ca2+ response in 77 % of cells studied . Negative_regulation CA2 TF 23258311 2757979 Throughout the evolution of vertebrates , transferrin members have diversified into distinct subfamilies including , ovotransferrin , lactoferrin , melanotransferrin , the *inhibitor* of [carbonic anhydrase] , pacifastin , and the major yolk protein in sea urchin . Negative_regulation CA2 TF 9461291 475785 Consequently , we examined the *role* of in internal free [Ca2+] regulation . Negative_regulation CA2 TNF 7598686 311317 PTX also enhanced *induced* down-regulation of acetylcholine mediated [ [Ca2+] ] i mobilization in neuroblastoma cells . Negative_regulation CA2 TNF 8521959 336461 TNF alpha receptor expression in rat cardiac myocytes : *inhibition* of L-type Ca2+ current and [Ca2+] transients . Negative_regulation CA2 TNF 9865597 556278 The release of *required* both a [Ca2] ( + ) -ATPase inhibitor and 12-O-tetradecanoylphorbol-13-acetate ( TPA ) . Negative_regulation CA2 TNF 9882452 584150 Endothelin stimulated [Ca2+] mobilization by 3T3-L1 adipocytes is *suppressed* by . Negative_regulation CA3 EPHB2 17822775 1882349 Both the increase of spines in CA1 and the decrease of thorns in [CA3] were completely *suppressed* by MAP kinase inhibitor . Negative_regulation CA3 MFI2 16111909 1454278 It includes serum transferrin , ovotransferrin , lactoferrin , , *inhibitor* of [carbonic anhydrase] , saxiphilin , the major yolk protein in sea urchins , the crayfish protein , pacifastin , and a protein from green algae . Negative_regulation CA3 TF 23258311 2757980 Throughout the evolution of vertebrates , transferrin members have diversified into distinct subfamilies including , ovotransferrin , lactoferrin , melanotransferrin , the *inhibitor* of [carbonic anhydrase] , pacifastin , and the major yolk protein in sea urchin . Negative_regulation CA4 MFI2 16111909 1454279 It includes serum transferrin , ovotransferrin , lactoferrin , , *inhibitor* of [carbonic anhydrase] , saxiphilin , the major yolk protein in sea urchins , the crayfish protein , pacifastin , and a protein from green algae . Negative_regulation CA4 TF 23258311 2757981 Throughout the evolution of vertebrates , transferrin members have diversified into distinct subfamilies including , ovotransferrin , lactoferrin , melanotransferrin , the *inhibitor* of [carbonic anhydrase] , pacifastin , and the major yolk protein in sea urchin . Negative_regulation CA6 MFI2 16111909 1454280 It includes serum transferrin , ovotransferrin , lactoferrin , , *inhibitor* of [carbonic anhydrase] , saxiphilin , the major yolk protein in sea urchins , the crayfish protein , pacifastin , and a protein from green algae . Negative_regulation CA6 TF 23258311 2757982 Throughout the evolution of vertebrates , transferrin members have diversified into distinct subfamilies including , ovotransferrin , lactoferrin , melanotransferrin , the *inhibitor* of [carbonic anhydrase] , pacifastin , and the major yolk protein in sea urchin . Negative_regulation CA7 MFI2 16111909 1454281 It includes serum transferrin , ovotransferrin , lactoferrin , , *inhibitor* of [carbonic anhydrase] , saxiphilin , the major yolk protein in sea urchins , the crayfish protein , pacifastin , and a protein from green algae . Negative_regulation CA7 TF 23258311 2757983 Throughout the evolution of vertebrates , transferrin members have diversified into distinct subfamilies including , ovotransferrin , lactoferrin , melanotransferrin , the *inhibitor* of [carbonic anhydrase] , pacifastin , and the major yolk protein in sea urchin . Negative_regulation CA8 MFI2 16111909 1454282 It includes serum transferrin , ovotransferrin , lactoferrin , , *inhibitor* of [carbonic anhydrase] , saxiphilin , the major yolk protein in sea urchins , the crayfish protein , pacifastin , and a protein from green algae . Negative_regulation CA8 TF 23258311 2757984 Throughout the evolution of vertebrates , transferrin members have diversified into distinct subfamilies including , ovotransferrin , lactoferrin , melanotransferrin , the *inhibitor* of [carbonic anhydrase] , pacifastin , and the major yolk protein in sea urchin . Negative_regulation CA9 MFI2 16111909 1454283 It includes serum transferrin , ovotransferrin , lactoferrin , , *inhibitor* of [carbonic anhydrase] , saxiphilin , the major yolk protein in sea urchins , the crayfish protein , pacifastin , and a protein from green algae . Negative_regulation CA9 TF 23258311 2757985 Throughout the evolution of vertebrates , transferrin members have diversified into distinct subfamilies including , ovotransferrin , lactoferrin , melanotransferrin , the *inhibitor* of [carbonic anhydrase] , pacifastin , and the major yolk protein in sea urchin . Negative_regulation CABP4 CALM3 6331894 40324 Trifluoperazine (TFP) , an *inhibitor* of the [calcium binding protein] , , was used to assess the role of calmodulin in the responses of rabbit lymphoid cells to stimulation with mitogen and antigen . Negative_regulation CABP4 MDK 10096022 560678 Disruption of the *resulted* in altered expression of a [calcium binding protein] in the hippocampus of infant mice and their abnormal behaviour . Negative_regulation CADM1 TNF 9705247 525871 Selective inhibition of *induced* [cell adhesion molecule] gene expression by tanapox virus . Negative_regulation CADM2 TNF 9705247 525869 Selective inhibition of *induced* [cell adhesion molecule] gene expression by tanapox virus . Negative_regulation CADM3 TNF 9705247 525868 Selective inhibition of *induced* [cell adhesion molecule] gene expression by tanapox virus . Negative_regulation CADM4 TNF 9705247 525870 Selective inhibition of *induced* [cell adhesion molecule] gene expression by tanapox virus . Negative_regulation CALCA NEDD9 10455189 638624 Phorbol 12-myristate 13-acetate also induced tyrosine phosphorylation , and the protein kinase C inhibitor calphostin C completely *inhibited* both [calcitonin-] and phorbol 12-myristate 13-acetate stimulated HEF1 phosphorylation . Negative_regulation CALD1 EPHB2 10712263 673969 Activation of , but not p38 MAP kinases , *results* in phosphorylation of [caldesmon] in vivo , which is a novel function for M ( 2 ) receptor activation in smooth muscle . Negative_regulation CALD1 TMOD1 16540476 1582096 We conclude that [caldesmon] inhibition of the rate of phosphate release is *caused* by the being switched by caldesmon to an inactive state . Negative_regulation CALM3 CABP4 6947252 18442 However , carp parvalbumin and chicken intestinal vitamin D-dependent do not *inhibit* the phenothiazine -- [calmodulin] interaction . Negative_regulation CALM3 SELL 10677354 668104 Prevention of [CaM-L-selectin] interaction by CaM inhibitors or mutation of a CaM binding site in L-selectin *induced* ectodomain shedding . Negative_regulation CALM3 TNF 23199585 2763728 [CAM] and AZM *induced* a dose dependent suppression of spontaneous , sTNFR2 , IL-6 , IL-8 and CCL18 production ( p < 0.05 ) . Negative_regulation CAMP EPHB2 22943069 2744943 HPL cells were treated with synthesized [LL37] in the *presence* or absence of PD98059 , a inhibitor , or PDTC , an NF-?B inhibitor . Negative_regulation CAMP MAP2K6 22943069 2744949 HPL cells were treated with synthesized [LL37] in the *presence* or absence of PD98059 , a inhibitor , or PDTC , an NF-?B inhibitor . Negative_regulation CAMP MUC16 18456648 1932970 This study shows that the antibacterial [LL-37] peptide and its synthetic analogue WLBU2 are *inhibited* by salivary and that the cationic steroid CSA-13 retains most of its function in the presence of an equal amount of mucin or saliva . Negative_regulation CAPN1 CABP4 12072431 975969 Interestingly , ectopic expression of a , calbindin-D(28k) , in MCF-7 cells not only *attenuated* the elevation in [ Ca ( 2+ ) ] ( i ) and [calpain] activation , but also reduced death triggered by vitamin D compounds . Negative_regulation CAPN1 CAPN8 16956607 1639534 This suggested that LSEAL had a inhibitory function and synthetic LSEAL *inhibited* [calpain I] and II proteolysis of two calpain substrates , tau and alpha-synuclein . Negative_regulation CAPN1 ITGB2 16894473 1597197 ( 1A ) decreased the Skp2 expression and *repressed* the activity of [calpain] during G1 phase in SMMC-7721 cells . Negative_regulation CAPN1 TNS1 7816056 285292 For control myofibrils , both 100 and 200 uM , *reduced* [calpain] degradation rates to a similar extent for all substrate proteins . Negative_regulation CAPN10 CABP4 12072431 975975 Interestingly , ectopic expression of a , calbindin-D(28k) , in MCF-7 cells not only *attenuated* the elevation in [ Ca ( 2+ ) ] ( i ) and [calpain] activation , but also reduced death triggered by vitamin D compounds . Negative_regulation CAPN10 ITGB2 16894473 1597205 ( 1A ) decreased the Skp2 expression and *repressed* the activity of [calpain] during G1 phase in SMMC-7721 cells . Negative_regulation CAPN10 TNS1 7816056 285293 For control myofibrils , both 100 and 200 uM , *reduced* [calpain] degradation rates to a similar extent for all substrate proteins . Negative_regulation CAPN11 CABP4 12072431 975981 Interestingly , ectopic expression of a , calbindin-D(28k) , in MCF-7 cells not only *attenuated* the elevation in [ Ca ( 2+ ) ] ( i ) and [calpain] activation , but also reduced death triggered by vitamin D compounds . Negative_regulation CAPN11 ITGB2 16894473 1597213 ( 1A ) decreased the Skp2 expression and *repressed* the activity of [calpain] during G1 phase in SMMC-7721 cells . Negative_regulation CAPN11 TNS1 7816056 285294 For control myofibrils , both 100 and 200 uM , *reduced* [calpain] degradation rates to a similar extent for all substrate proteins . Negative_regulation CAPN12 CABP4 12072431 975963 Interestingly , ectopic expression of a , calbindin-D(28k) , in MCF-7 cells not only *attenuated* the elevation in [ Ca ( 2+ ) ] ( i ) and [calpain] activation , but also reduced death triggered by vitamin D compounds . Negative_regulation CAPN12 ITGB2 16894473 1597189 ( 1A ) decreased the Skp2 expression and *repressed* the activity of [calpain] during G1 phase in SMMC-7721 cells . Negative_regulation CAPN12 TNS1 7816056 285291 For control myofibrils , both 100 and 200 uM , *reduced* [calpain] degradation rates to a similar extent for all substrate proteins . Negative_regulation CAPN13 CABP4 12072431 976029 Interestingly , ectopic expression of a , calbindin-D(28k) , in MCF-7 cells not only *attenuated* the elevation in [ Ca ( 2+ ) ] ( i ) and [calpain] activation , but also reduced death triggered by vitamin D compounds . Negative_regulation CAPN13 ITGB2 16894473 1597277 ( 1A ) decreased the Skp2 expression and *repressed* the activity of [calpain] during G1 phase in SMMC-7721 cells . Negative_regulation CAPN13 TNS1 7816056 285302 For control myofibrils , both 100 and 200 uM , *reduced* [calpain] degradation rates to a similar extent for all substrate proteins . Negative_regulation CAPN14 CABP4 12072431 976035 Interestingly , ectopic expression of a , calbindin-D(28k) , in MCF-7 cells not only *attenuated* the elevation in [ Ca ( 2+ ) ] ( i ) and [calpain] activation , but also reduced death triggered by vitamin D compounds . Negative_regulation CAPN14 ITGB2 16894473 1597285 ( 1A ) decreased the Skp2 expression and *repressed* the activity of [calpain] during G1 phase in SMMC-7721 cells . Negative_regulation CAPN14 TNS1 7816056 285303 For control myofibrils , both 100 and 200 uM , *reduced* [calpain] degradation rates to a similar extent for all substrate proteins . Negative_regulation CAPN15 CABP4 12072431 975957 Interestingly , ectopic expression of a , calbindin-D(28k) , in MCF-7 cells not only *attenuated* the elevation in [ Ca ( 2+ ) ] ( i ) and [calpain] activation , but also reduced death triggered by vitamin D compounds . Negative_regulation CAPN15 ITGB2 16894473 1597181 ( 1A ) decreased the Skp2 expression and *repressed* the activity of [calpain] during G1 phase in SMMC-7721 cells . Negative_regulation CAPN15 TNS1 7816056 285290 For control myofibrils , both 100 and 200 uM , *reduced* [calpain] degradation rates to a similar extent for all substrate proteins . Negative_regulation CAPN2 CABP4 12072431 975987 Interestingly , ectopic expression of a , calbindin-D(28k) , in MCF-7 cells not only *attenuated* the elevation in [ Ca ( 2+ ) ] ( i ) and [calpain] activation , but also reduced death triggered by vitamin D compounds . Negative_regulation CAPN2 CAPN8 12540781 1050647 In other studies , calpain activity and [m-calpain] and mu-calpain expression were measured during cold preservation in the *presence* or absence of inhibitors . Negative_regulation CAPN2 CAPN8 8845743 337975 Role of in spinal cord injury : *increased* [mcalpain] immunoreactivity in spinal cord after compression injury in the rat . Negative_regulation CAPN2 ITGB2 16894473 1597221 ( 1A ) decreased the Skp2 expression and *repressed* the activity of [calpain] during G1 phase in SMMC-7721 cells . Negative_regulation CAPN2 TNF 10600505 573864 In RA FLS , although IL-6 did not alter m-calpain mRNA expression , IL-1 <+ tumor necrosis factor> ( TNF ) and IL-1 + transforming growth factor ( TGF ) *down-regulated* [m-calpain] mRNA expression . Negative_regulation CAPN2 TNS1 7816056 285295 For control myofibrils , both 100 and 200 uM , *reduced* [calpain] degradation rates to a similar extent for all substrate proteins . Negative_regulation CAPN3 CABP4 12072431 975993 Interestingly , ectopic expression of a , calbindin-D(28k) , in MCF-7 cells not only *attenuated* the elevation in [ Ca ( 2+ ) ] ( i ) and [calpain] activation , but also reduced death triggered by vitamin D compounds . Negative_regulation CAPN3 ITGB2 16894473 1597229 ( 1A ) decreased the Skp2 expression and *repressed* the activity of [calpain] during G1 phase in SMMC-7721 cells . Negative_regulation CAPN3 TNS1 7816056 285296 For control myofibrils , both 100 and 200 uM , *reduced* [calpain] degradation rates to a similar extent for all substrate proteins . Negative_regulation CAPN5 CABP4 12072431 975999 Interestingly , ectopic expression of a , calbindin-D(28k) , in MCF-7 cells not only *attenuated* the elevation in [ Ca ( 2+ ) ] ( i ) and [calpain] activation , but also reduced death triggered by vitamin D compounds . Negative_regulation CAPN5 ITGB2 16894473 1597237 ( 1A ) decreased the Skp2 expression and *repressed* the activity of [calpain] during G1 phase in SMMC-7721 cells . Negative_regulation CAPN5 TNS1 7816056 285297 For control myofibrils , both 100 and 200 uM , *reduced* [calpain] degradation rates to a similar extent for all substrate proteins . Negative_regulation CAPN6 CABP4 12072431 976005 Interestingly , ectopic expression of a , calbindin-D(28k) , in MCF-7 cells not only *attenuated* the elevation in [ Ca ( 2+ ) ] ( i ) and [calpain] activation , but also reduced death triggered by vitamin D compounds . Negative_regulation CAPN6 ITGB2 16894473 1597245 ( 1A ) decreased the Skp2 expression and *repressed* the activity of [calpain] during G1 phase in SMMC-7721 cells . Negative_regulation CAPN6 TNS1 7816056 285298 For control myofibrils , both 100 and 200 uM , *reduced* [calpain] degradation rates to a similar extent for all substrate proteins . Negative_regulation CAPN7 CABP4 12072431 976011 Interestingly , ectopic expression of a , calbindin-D(28k) , in MCF-7 cells not only *attenuated* the elevation in [ Ca ( 2+ ) ] ( i ) and [calpain] activation , but also reduced death triggered by vitamin D compounds . Negative_regulation CAPN7 ITGB2 16894473 1597253 ( 1A ) decreased the Skp2 expression and *repressed* the activity of [calpain] during G1 phase in SMMC-7721 cells . Negative_regulation CAPN7 TNS1 7816056 285299 For control myofibrils , both 100 and 200 uM , *reduced* [calpain] degradation rates to a similar extent for all substrate proteins . Negative_regulation CAPN8 ABCA1 12511593 1038837 In an apparent positive feedback loop , apoA-I binds , promotes lipid efflux , *inhibits* [calpain] degradation , and leads to increased levels of ABCA1 . Negative_regulation CAPN8 ABCA1 22248050 2564295 Like lipid-free apolipoprotein A-I (apoA-I) , tyrHDL increases total and cell surface , *inhibits* [calpain dependent and -independent] proteolysis of ABCA1 , and can be bound by cell surface ABCA1 in human skin fibroblasts . Negative_regulation CAPN8 ADRBK1 16963227 1673437 The hydrogen peroxide induced decrease in GRK2 is prevented by a [calpain] protease inhibitor , but does not *involve* increased GRK2 degradation or changes in mRNA level . Negative_regulation CAPN8 APOA1 12511593 1038838 In an apparent positive feedback loop , binds ABCA1 , promotes lipid efflux , *inhibits* [calpain] degradation , and leads to increased levels of ABCA1 . Negative_regulation CAPN8 ATP2A2 18071073 1854337 The peroxisome proliferator activated receptor-gamma agonist rosiglitazone increased SERCA-2 expression in megakaryocytes , and treating patients with type 2 diabetes mellitus with rosiglitazone for 12 weeks increased platelet expression and Ca2+-ATPase activity , decreased SERCA-2 tyrosine nitration , and normalized platelet [Ca2+ ] i. Rosiglitazone also *reduced* [mu-calpain] activity , normalized platelet endothelial cell adhesion molecule-1 levels , and partially restored platelet sensitivity to nitric oxide synthase inhibition . Negative_regulation CAPN8 ATP5O 18071073 1854338 The peroxisome proliferator activated receptor-gamma agonist rosiglitazone increased SERCA-2 expression in megakaryocytes , and treating patients with type 2 diabetes mellitus with rosiglitazone for 12 weeks increased platelet SERCA-2 expression and activity , decreased SERCA-2 tyrosine nitration , and normalized platelet [Ca2+ ] i. Rosiglitazone also *reduced* [mu-calpain] activity , normalized platelet endothelial cell adhesion molecule-1 levels , and partially restored platelet sensitivity to nitric oxide synthase inhibition . Negative_regulation CAPN8 BCL2 11029754 739926 Finally , overexpression *inhibited* etoposide induced [calpain] activation , Bax cleavage , cytochrome c release , and apoptosis . Negative_regulation CAPN8 BCL2 11413236 828486 Cleavage of Bax is mediated by caspase dependent or -independent [calpain] *activation* in dopaminergic neuronal cells : protective role of . Negative_regulation CAPN8 CA2 12937083 1151482 Both depletion and [calpain] *inhibition* protected the cytoskeleton from degradation , as assessed by immunohistological and ultrastructural analysis . Negative_regulation CAPN8 CA2 18071073 1854336 The peroxisome proliferator activated receptor-gamma agonist rosiglitazone increased SERCA-2 expression in megakaryocytes , and treating patients with type 2 diabetes mellitus with rosiglitazone for 12 weeks increased platelet SERCA-2 expression and activity , decreased SERCA-2 tyrosine nitration , and normalized platelet [Ca2+ ] i. Rosiglitazone also *reduced* [mu-calpain] activity , normalized platelet endothelial cell adhesion molecule-1 levels , and partially restored platelet sensitivity to nitric oxide synthase inhibition . Negative_regulation CAPN8 CA2 9928631 559962 In the *presence* of 1 microM free , 10 pM free Pb2+ reduced [calpain] activity , but in the presence of 100 microM free Ca2+ , 1 nM free Pb2+ failed to inhibit calpain . Negative_regulation CAPN8 CABP1 12072431 976015 Interestingly , ectopic expression of a , calbindin-D(28k) , in MCF-7 cells not only *attenuated* the elevation in [ Ca ( 2+ ) ] ( i ) and [calpain] activation , but also reduced death triggered by vitamin D compounds . Negative_regulation CAPN8 CABP2 12072431 976016 Interestingly , ectopic expression of a , calbindin-D(28k) , in MCF-7 cells not only *attenuated* the elevation in [ Ca ( 2+ ) ] ( i ) and [calpain] activation , but also reduced death triggered by vitamin D compounds . Negative_regulation CAPN8 CABP4 12072431 976017 Interestingly , ectopic expression of a , calbindin-D(28k) , in MCF-7 cells not only *attenuated* the elevation in [ Ca ( 2+ ) ] ( i ) and [calpain] activation , but also reduced death triggered by vitamin D compounds . Negative_regulation CAPN8 CABP5 12072431 976014 Interestingly , ectopic expression of a , calbindin-D(28k) , in MCF-7 cells not only *attenuated* the elevation in [ Ca ( 2+ ) ] ( i ) and [calpain] activation , but also reduced death triggered by vitamin D compounds . Negative_regulation CAPN8 CABP7 12072431 976019 Interestingly , ectopic expression of a , calbindin-D(28k) , in MCF-7 cells not only *attenuated* the elevation in [ Ca ( 2+ ) ] ( i ) and [calpain] activation , but also reduced death triggered by vitamin D compounds . Negative_regulation CAPN8 CALB1 12072431 976018 Interestingly , ectopic expression of a calcium binding protein , , in MCF-7 cells not only *attenuated* the elevation in [ Ca ( 2+ ) ] ( i ) and [calpain] activation , but also reduced death triggered by vitamin D compounds . Negative_regulation CAPN8 CALCA 16461769 1540931 Calcitonin inhibited the constitutive cleavage of a fluorogenic calpain substrate and transiently blocked the constitutive cleavage of filamin A , talin , and Pyk2 by a protein kinase C-dependent mechanism , demonstrating that *induces* the inhibition of [calpain] in osteoclasts . Negative_regulation CAPN8 CALM3 1328642 197872 this finding together with the *inhibition* of [calpain] imply that the JFP is a PEDST-type calpain substrate . Negative_regulation CAPN8 CAPN1 24607452 2929961 These data showed that ( i ) physiologically elevated cytosolic Ca ( 2+ ) concentrations were sufficient to trigger activation , blockade of Ca ( 2+ ) influx *preventing* [calpain] activation and ( ii ) calpain-1 activity was elevated in spreading neutrophil . Negative_regulation CAPN8 CAPN2 9067861 418890 In contrast , both acidic FGF and basic FGF stimulated mu calpain ( 37 % ) and ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 CAPN3 19105197 2042084 In vivo , NMDA immediately decreased G-substrate immunoreactivity , and the suppression of calpain activation using ALLN or , an *inhibitor* of [calpain] , blocked this decrease . Negative_regulation CAPN8 CAPNS1 24607452 2929962 These data showed that ( i ) physiologically elevated cytosolic Ca ( 2+ ) concentrations were sufficient to trigger activation , blockade of Ca ( 2+ ) influx *preventing* [calpain] activation and ( ii ) calpain-1 activity was elevated in spreading neutrophil . Negative_regulation CAPN8 CASP1 11054482 745558 Although rigorous study of multi-drug protocols is very demanding , effective therapy is likely to require ( 1 ) peptide growth factors for early activation of survival signaling pathways and recovery of translation competence , ( 2 ) inhibition of lipid peroxidation , ( 3 ) *inhibition* of [calpain] , and ( 4 ) inhibition . Negative_regulation CAPN8 CASP1 12199150 982374 Staurosporine induced loss of neuronal particles was blocked by nonselective inhibition ( z-VAD-fmk ) and by [calpain] *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CAPN8 CASP1 20080185 2225779 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known inhibitor Z-VAD fmk or by [calpain] *inhibition* . Negative_regulation CAPN8 CASP1 8920967 396667 The formation of the 120 kDa SBDP was insensitive to [calpain] inhibitors but was completely *blocked* by an ( ICE ) -like protease inhibitor , Z-Asp-CH2OC ( O ) -2,6-dichlorobenzene . Negative_regulation CAPN8 CASP10 11054482 745559 Although rigorous study of multi-drug protocols is very demanding , effective therapy is likely to require ( 1 ) peptide growth factors for early activation of survival signaling pathways and recovery of translation competence , ( 2 ) inhibition of lipid peroxidation , ( 3 ) inhibition of [calpain] , and ( 4 ) *inhibition* . Negative_regulation CAPN8 CASP10 12199150 982375 Staurosporine induced loss of neuronal particles was blocked by nonselective inhibition ( z-VAD-fmk ) and by [calpain] *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CAPN8 CASP10 20080185 2225780 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known inhibitor Z-VAD fmk or by [calpain] *inhibition* . Negative_regulation CAPN8 CASP12 11054482 745569 Although rigorous study of multi-drug protocols is very demanding , effective therapy is likely to require ( 1 ) peptide growth factors for early activation of survival signaling pathways and recovery of translation competence , ( 2 ) inhibition of lipid peroxidation , ( 3 ) inhibition of [calpain] , and ( 4 ) *inhibition* . Negative_regulation CAPN8 CASP12 12199150 982385 Staurosporine induced loss of neuronal particles was blocked by nonselective inhibition ( z-VAD-fmk ) and by [calpain] *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CAPN8 CASP12 20080185 2225790 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known inhibitor Z-VAD fmk or by [calpain] *inhibition* . Negative_regulation CAPN8 CASP14 11054482 745560 Although rigorous study of multi-drug protocols is very demanding , effective therapy is likely to require ( 1 ) peptide growth factors for early activation of survival signaling pathways and recovery of translation competence , ( 2 ) inhibition of lipid peroxidation , ( 3 ) *inhibition* of [calpain] , and ( 4 ) inhibition . Negative_regulation CAPN8 CASP14 12199150 982376 Staurosporine induced loss of neuronal particles was blocked by nonselective inhibition ( z-VAD-fmk ) and by [calpain] *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CAPN8 CASP14 20080185 2225781 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known inhibitor Z-VAD fmk or by [calpain] *inhibition* . Negative_regulation CAPN8 CASP16 11054482 745570 Although rigorous study of multi-drug protocols is very demanding , effective therapy is likely to require ( 1 ) peptide growth factors for early activation of survival signaling pathways and recovery of translation competence , ( 2 ) inhibition of lipid peroxidation , ( 3 ) *inhibition* of [calpain] , and ( 4 ) inhibition . Negative_regulation CAPN8 CASP16 12199150 982386 Staurosporine induced loss of neuronal particles was blocked by nonselective inhibition ( z-VAD-fmk ) and by [calpain] *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CAPN8 CASP16 20080185 2225791 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known inhibitor Z-VAD fmk or by [calpain] *inhibition* . Negative_regulation CAPN8 CASP2 11054482 745561 Although rigorous study of multi-drug protocols is very demanding , effective therapy is likely to require ( 1 ) peptide growth factors for early activation of survival signaling pathways and recovery of translation competence , ( 2 ) inhibition of lipid peroxidation , ( 3 ) inhibition of [calpain] , and ( 4 ) *inhibition* . Negative_regulation CAPN8 CASP2 12199150 982377 Staurosporine induced loss of neuronal particles was blocked by nonselective inhibition ( z-VAD-fmk ) and by [calpain] *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CAPN8 CASP2 20080185 2225782 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known inhibitor Z-VAD fmk or by [calpain] *inhibition* . Negative_regulation CAPN8 CASP3 11054482 745562 Although rigorous study of multi-drug protocols is very demanding , effective therapy is likely to require ( 1 ) peptide growth factors for early activation of survival signaling pathways and recovery of translation competence , ( 2 ) inhibition of lipid peroxidation , ( 3 ) *inhibition* of [calpain] , and ( 4 ) inhibition . Negative_regulation CAPN8 CASP3 12199150 982378 Staurosporine induced loss of neuronal particles was blocked by nonselective inhibition ( z-VAD-fmk ) and by [calpain] *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CAPN8 CASP3 12851726 1109681 Furthermore , pretreatment with the specific pharmacological calpain inhibitor calpeptin blocked the drug induced calpain small subunit autolysis and [calpain] activation in mitochondria and *inhibited* apoptosis associated activation , demonstrating that mitochondrial calpain activation through small subunit cleavage is an essential step for inducing tumor cell apoptosis by various anticancer drugs . Negative_regulation CAPN8 CASP3 14527821 1148950 was also activated by simvastatin after 12 h. Verapamil and PD150606 , a cell-permeable selective calpain inhibitor , significantly *inhibited* simvastatin induced augmentation of [calpain] activity and blocked caspase-3 activation , respectively . Negative_regulation CAPN8 CASP3 18031600 1828315 SF reduced glutamate evoked apoptotic morphology , protein expression , and PARP cleavage and *inhibited* the glutamate induced upregulation of the [mu-calpain] protein level . Negative_regulation CAPN8 CASP3 20080185 2225783 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known inhibitor Z-VAD fmk or by [calpain] *inhibition* . Negative_regulation CAPN8 CASP3 21683092 2500092 The obtained data provided evidence for neuroprotective potency of MAPK/ERK1/2 and [calpain] , but not *inhibition* against the neurotoxic effects of LC in primary cortical neurons and give rationale for using these inhibitors in the treatment of neurodegenerative diseases connected with proteasome dysfunction . Negative_regulation CAPN8 CASP3 22237475 2569288 Amiloride also inhibited [calpain] and calcineurin expression levels in acid induced chondrocytes , and *inhibited* activity . Negative_regulation CAPN8 CASP4 11054482 745563 Although rigorous study of multi-drug protocols is very demanding , effective therapy is likely to require ( 1 ) peptide growth factors for early activation of survival signaling pathways and recovery of translation competence , ( 2 ) inhibition of lipid peroxidation , ( 3 ) inhibition of [calpain] , and ( 4 ) *inhibition* . Negative_regulation CAPN8 CASP4 12199150 982379 Staurosporine induced loss of neuronal particles was blocked by nonselective inhibition ( z-VAD-fmk ) and by [calpain] *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CAPN8 CASP4 20080185 2225784 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known inhibitor Z-VAD fmk or by [calpain] *inhibition* . Negative_regulation CAPN8 CASP5 11054482 745564 Although rigorous study of multi-drug protocols is very demanding , effective therapy is likely to require ( 1 ) peptide growth factors for early activation of survival signaling pathways and recovery of translation competence , ( 2 ) inhibition of lipid peroxidation , ( 3 ) *inhibition* of [calpain] , and ( 4 ) inhibition . Negative_regulation CAPN8 CASP5 12199150 982380 Staurosporine induced loss of neuronal particles was blocked by nonselective inhibition ( z-VAD-fmk ) and by [calpain] *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CAPN8 CASP5 20080185 2225785 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known inhibitor Z-VAD fmk or by [calpain] *inhibition* . Negative_regulation CAPN8 CASP6 11054482 745565 Although rigorous study of multi-drug protocols is very demanding , effective therapy is likely to require ( 1 ) peptide growth factors for early activation of survival signaling pathways and recovery of translation competence , ( 2 ) inhibition of lipid peroxidation , ( 3 ) inhibition of [calpain] , and ( 4 ) *inhibition* . Negative_regulation CAPN8 CASP6 12199150 982381 Staurosporine induced loss of neuronal particles was blocked by nonselective inhibition ( z-VAD-fmk ) and by [calpain] *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CAPN8 CASP6 20080185 2225786 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known inhibitor Z-VAD fmk or by [calpain] *inhibition* . Negative_regulation CAPN8 CASP7 11054482 745566 Although rigorous study of multi-drug protocols is very demanding , effective therapy is likely to require ( 1 ) peptide growth factors for early activation of survival signaling pathways and recovery of translation competence , ( 2 ) inhibition of lipid peroxidation , ( 3 ) *inhibition* of [calpain] , and ( 4 ) inhibition . Negative_regulation CAPN8 CASP7 12199150 982382 Staurosporine induced loss of neuronal particles was blocked by nonselective inhibition ( z-VAD-fmk ) and by [calpain] *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CAPN8 CASP7 20080185 2225787 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known inhibitor Z-VAD fmk or by [calpain] *inhibition* . Negative_regulation CAPN8 CASP8 11054482 745567 Although rigorous study of multi-drug protocols is very demanding , effective therapy is likely to require ( 1 ) peptide growth factors for early activation of survival signaling pathways and recovery of translation competence , ( 2 ) inhibition of lipid peroxidation , ( 3 ) inhibition of [calpain] , and ( 4 ) *inhibition* . Negative_regulation CAPN8 CASP8 12199150 982383 Staurosporine induced loss of neuronal particles was blocked by nonselective inhibition ( z-VAD-fmk ) and by [calpain] *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CAPN8 CASP8 18038901 1828505 Moreover , [calpain] activity was *inhibited* by calpain inhibitors such as ALLN or leupeptin , but not by inhibitor peptide . Negative_regulation CAPN8 CASP8 20080185 2225788 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known inhibitor Z-VAD fmk or by [calpain] *inhibition* . Negative_regulation CAPN8 CASP9 11054482 745568 Although rigorous study of multi-drug protocols is very demanding , effective therapy is likely to require ( 1 ) peptide growth factors for early activation of survival signaling pathways and recovery of translation competence , ( 2 ) inhibition of lipid peroxidation , ( 3 ) *inhibition* of [calpain] , and ( 4 ) inhibition . Negative_regulation CAPN8 CASP9 12199150 982384 Staurosporine induced loss of neuronal particles was blocked by nonselective inhibition ( z-VAD-fmk ) and by [calpain] *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CAPN8 CASP9 20080185 2225789 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known inhibitor Z-VAD fmk or by [calpain] *inhibition* . Negative_regulation CAPN8 CAST 10222112 609575 I , a selective *inhibitor* of [mu-calpain] , also significantly reduced reactive gliosis . Negative_regulation CAPN8 CAST 10601241 574286 Evidence for the involvement of calpain inhibition in this process was obtained by the demonstration that 1 ) somatostatin induced a dose dependent decrease in calpain activity and 2 ) [calpain] *inhibitors* , I and calpeptin , both abolished the cleavage of Hsp 90 and induced a dose dependent increase in [ ( 3 ) H ] dexamethasone binding . Negative_regulation CAPN8 CAST 10749891 698679 Likewise , inhibition of calpain by overexpression of , the specific endogenous *inhibitor* of [calpain] , prevents 2-day post-confluent preadipocytes from reentering the cell cycle triggered by the differentiation inducers . Negative_regulation CAPN8 CAST 10822276 694821 The expression of , a specific endogenous *inhibitor* of [calpain] , was higher in RSa than in UVr-1 cells . Negative_regulation CAPN8 CAST 10876161 708879 , a specific *inhibitor* of [calpain] , consists of a unique N-terminal domain ( domain L ) and four repetitive protease-inhibitor domains ( domains 1-4 ) . Negative_regulation CAPN8 CAST 10942721 722638 To address the involvement of the calpain system in both basal and silica induced nuclear factor (NF)-kappaB activation , several human bronchial epithelial cell lines were established in which an intracellular *inhibitor* of [calpain] , , was stably expressed . Negative_regulation CAPN8 CAST 11518218 851521 Activity of the myofibril bound [calpain] was partly ( 58 to 67 % ) inhibited by the calpain inhibitors , E-64 and iodoacetate ; was more effectively inhibited by a broader based protease inhibitor , leupeptin ( 84 to 89 % ) ; and was poorly *inhibited* ( 43 to 45 % ) by . Negative_regulation CAPN8 CAST 11779201 900050 To elucidate further the effects of calpain in malignant transformation of NIH3T3 cells , , an endogenous specific *inhibitor* of [calpain] , was expressed in NIH3T3 cells by transfection with cDNA . Negative_regulation CAPN8 CAST 12119304 984897 m-Calpain was not activated , but mu-calpain was activated at an abnormally high level , and an endogenous *inhibitor* of [calpain] , , was significantly decreased . Negative_regulation CAPN8 CAST 12715890 1083708 exon 1B-derived peptide , a selective *inhibitor* of [calpain] : enhancing cell permeability by conjugation with penetratin . Negative_regulation CAPN8 CAST 12738057 1087918 Calpain is widely expressed in the central nervous system ( CNS ) and regulated by , an endogenous [calpain-specific] *inhibitor* . Negative_regulation CAPN8 CAST 14500891 1144322 , the endogenous *inhibitor* of [calpain] , is an intrinsically unstructured protein proposed to undergo folding transitions upon binding to the enzyme . Negative_regulation CAPN8 CAST 14612448 1200491 Decreased levels of , a highly specific intrinsic *inhibitor* of [calpain] , resulted in activation of calpain-1 , but not calpain-2 , in neutrophils undergoing apoptosis , a process that was blocked by a specific calpain-1 inhibitor or by intracellular delivery of a calpastatin peptide . Negative_regulation CAPN8 CAST 14995081 1182938 We investigated the effect of leupeptin and , two [calpain] *inhibitors* and of a caspase-3 inhibitor , Ac-DEVD-CHO , on functional recovery , myocardial infarct size and apoptosis in isolated rat hearts ( Langendorff technique ) subjected to 30 min of global ischemia and 120 min of reperfusion . Negative_regulation CAPN8 CAST 14996907 1220459 In the absence of Foxj1 , the expression of , an *inhibitor* of the protease [calpain] , decreased . Negative_regulation CAPN8 CAST 15180919 1288642 , a specific *inhibitor* of [calpain] , potentiates inhibitory effect of CSE on the endothelial monolayer wound repair , tube formation , cell migration , and cell proliferation . Negative_regulation CAPN8 CAST 15302874 1303291 The activity of calpain is modulated by two regulatory proteins , , the specific endogenous *inhibitor* of [calpain] , and the 28-kDa regulatory subunit . Negative_regulation CAPN8 CAST 1569094 187055 , a specific *inhibitor* of [calpain] , consists of a unique N-terminal domain ( domain L ) and four repetitive calpain-inhibition domains ( domains 1-4 ) . Negative_regulation CAPN8 CAST 15691895 1388590 The absence of [calpain] in Capn4-null embryonic fibroblasts and the lowered calpain activity in MC3T3-E1 osteoblastic cells *due* to stable expression of the , calpastatin , reduce PTH stimulated cAMP accumulation . Negative_regulation CAPN8 CAST 15886234 1439830 The presence of PGE2 stimulated calpain activity , whereas two [calpain] *inhibitors* , and N-Ac-Leu-Leu-methioninal (ALLM) , blocked EVT migration . Negative_regulation CAPN8 CAST 16385561 1520108 The restoration of pCREB by protein phosphatase (PP)-1/2A inhibitors or the inhibition of excessive *activation* of [calpain] by did not reduce OGD/reoxygenation induced LDH release . Negative_regulation CAPN8 CAST 16857754 1613358 After exposure to the calpain inhibitor , N-benzyloxycarbonyl-L-leucyl-L-leucinal or overexpression of , a specific endogenous *inhibitor* of [calpain] , ST-13 preadipocytes acquired the adipocyte phenotype . Negative_regulation CAPN8 CAST 16871587 1593186 By examining expression of , an endogenous *inhibitor* of [calpain] in three liver cell division models known to be resistant to hepatotoxicity , we tested the hypothesis that increased CAST in the dividing hepatocytes affords resistance against progression of injury . Negative_regulation CAPN8 CAST 16876115 1600815 , an endogenous *inhibitor* of [calpain] , is composed of domain L and four repetitive homologous domains 1-4 . Negative_regulation CAPN8 CAST 18001554 1827094 *suppresses* the increased [calpain] activity and reverses the structural remodeling of sustained atrial fibrillation . Negative_regulation CAPN8 CAST 18157632 1869224 however , it had no significant effects on the [mu-calpain] activities in core and the levels in penumbra at R 23 h . Calpain inhibitor I ( 0.8 mg/rat , i.c.v. ) markedly *reduced* the caspase-3 activities in core at R 3 h and R 23 h , but not in penumbra . Negative_regulation CAPN8 CAST 18208663 1857638 , ALLM , *suppressed* the increased [calpain] activity and reversed structural remodeling caused by sustained atrial fibrillation in the present model . Negative_regulation CAPN8 CAST 18258859 1884882 We generated transgenic mice constitutively expressing high levels of , a [calpain-specific] *inhibitor* . Negative_regulation CAPN8 CAST 18395616 1893617 Moreover , MDL-28170 , a , partially rescued the neuron death and *attenuated* the expression of activated [mu-calpain] , cleavage of Bid ( 15 kDa ) , AIF translocation and cytochrome c release . Negative_regulation CAPN8 CAST 18786620 1980660 Overexpression of also *inhibited* Ca ( 2+ ) -promoted [calpain] activation and protein degradation ; Negative_regulation CAPN8 CAST 18950702 2014213 Pharmacological inhibitors of calpain or overexpression of , a specific calpain inhibitor , *blocked* [calpain] activation and prevented cardiomyocyte apoptosis during NE stimulation . Negative_regulation CAPN8 CAST 1895100 167279 The polyamines did not increase the activity of purified calpain I or calpain II determined with either [ 14C ] casein or purified spectrin as the substrate , nor did they interfere with the inhibitory effects of , an endogenous *inhibitor* of [calpain] . Negative_regulation CAPN8 CAST 19318376 2087078 Over-expression of *inhibits* [calpain] activation and attenuates myocardial dysfunction during endotoxaemia . Negative_regulation CAPN8 CAST 19318376 2087092 These effects of LPS were abrogated by over-expression of , an endogenous calpain inhibitor , transfection of calpain-1 siRNA , or various pharmacological [calpain] *inhibitors* . Negative_regulation CAPN8 CAST 19318376 2087159 Over-expression of *inhibits* [calpain] activation and improves myocardial function in endotoxaemia . Negative_regulation CAPN8 CAST 21156051 2358137 Expression of , the endogenous *inhibitor* of [calpain] , was decreased in the CMV and low MP groups but its level was preserved to controls in the high MP group . Negative_regulation CAPN8 CAST 21268016 2380674 To address the role of calpain in rejection , we used a skin transplant model in transgenic mice expressing high levels of , a [calpain-specific] *inhibitor* . Negative_regulation CAPN8 CAST 21982763 2498004 Thus , PIN1 apparently restrains the ability of to *inhibit* [calpain] , maintaining calpain activity in endothelial cells . Negative_regulation CAPN8 CAST 22062138 655811 Feed restriction increased protein degradation in hind-limb muscle of lambs ( p < 0.1 ) , with a concominant decrease in the extractable activity of ( p < 0.01 ) , the endogenous *inhibitor* of [calpain] . Negative_regulation CAPN8 CAST 22073041 2504371 We found that EHEC infection results in an increase in epithelial ( CaCo-2a ) cell [calpain] activity and that EHEC induced microvillar effacement was *blocked* by ectopic expression of , an endogenous calpain inhibitor , or by pretreatment of intestinal cells with a cell penetrating version of calpastatin . Negative_regulation CAPN8 CAST 22095979 2540969 A rapidly progressive form of glomerulonephritis in wild type and transgenic mice expressing high levels of , a [calpain-specific] *inhibitor* , was studied . Negative_regulation CAPN8 CAST 22268136 2575523 To test our hypothesis , we induced polymicrobial sepsis by cecal ligation and puncture in wild-type ( WT ) mice and transgenic mice expressing high levels of , a [calpain-specific] *inhibitor* . Negative_regulation CAPN8 CAST 22688056 2633562 In this study , we analyzed the potential therapeutic efficacy of inhibiting the *activation* of [calpain] by a novel in aged 3xTgAD mice with well established cognitive impairment , plaques , and tangles . Negative_regulation CAPN8 CAST 22843411 2635652 For this purpose , we *inhibited* [calpain] activity in mouse models of Machado-Joseph disease by overexpressing the endogenous calpain-inhibitor . Negative_regulation CAPN8 CAST 23295187 2737851 Production of these fragments was inhibited by , the endogenous and specific *inhibitor* of [calpain] . Negative_regulation CAPN8 CAST 23365236 2738953 Three [calpain] *inhibitors* , I , MDL-28170 , and PD150606 , but not the control compound PD145305 , inhibit LFD both in the intact animal as shown by electromyograms and by intracellular recordings at neuromuscular junctions . Negative_regulation CAPN8 CAST 23707532 2806307 HER2 regulates Brk/PTK6 stability via upregulating , an *inhibitor* of [calpain] . Negative_regulation CAPN8 CAST 23989868 2856046 Meanwhile , it has been shown that caspase-3 can cleave , the *inhibitor* of [µ-calpain] . Negative_regulation CAPN8 CAST 24200051 2875715 Trichostatin A epigenetically increases expression and *inhibits* [calpain] activity and calcium induced SH-SY5Y neuronal cell toxicity . Negative_regulation CAPN8 CAST 24441549 2922897 In calpastatin transgenic mice , an endogenous and cultured neonatal mouse cardiomyocytes overexpressing calpastatin also *inhibited* [calpain] activity , I?Ba protein degradation , and NF-?B activation after LPS treatment . Negative_regulation CAPN8 CAST 25052996 2953507 Loss of *leads* to activation of [calpain] in human lens epithelial cells . Negative_regulation CAPN8 CAST 25052996 2953521 The hypothesis is that high levels of human endogenous , calpastatin (CS) , *prevent* [calpain] activation in human lenses . Negative_regulation CAPN8 CAST 2555371 122032 Removal of , the endogenous inhibitor of the calpains , by phenyl-Sepharose chromatography *increases* the [calpain] activity of extracts from both control and nerve growth factor treated cells and brings the activity in the extracts from treated cells up to the activity in those from controls . Negative_regulation CAPN8 CAST 2883970 73090 Activation of platelet factor XIII by [calpain] was *inhibited* by EDTA , leupeptin , and endogenous calpain-specific inhibitor . Negative_regulation CAPN8 CAST 2985174 47549 In contrast , a previously described endogenous *inhibitor* of [calpain] , <'calpastatin> ' , was found not to vary in its activity across brain regions . Negative_regulation CAPN8 CAST 2998223 53251 Because may *prevent* binding of [calpain] to phenyl-Sepharose by forming a protease-inhibitor complex in the presence of Ca2+ , preadsorbing the protease to a suspension of phenyl-Sepharose beads initially in the absence of Ca2+ separates most of the calpain present in tissue extracts from calpastatin . Negative_regulation CAPN8 CAST 6290462 23247 The Ca2+ induced weakening of Z disks and the Z-disk removal by muscle calpain could be clearly distinguished by using muscle , an endogenous *inhibitor* of muscle [calpain] . Negative_regulation CAPN8 CAST 6327382 37743 The cleavage was dependent on Ca2+ and could be blocked by , a [calpain-specific] *inhibitor* . Negative_regulation CAPN8 CAST 6897650 25465 Human erythrocyte could *inhibit* not only [calpain] of the same origin but also calpains having low and high Ca2+-sensitivity from rat liver . Negative_regulation CAPN8 CAST 7559644 328204 Furthermore , the introduction of a synthetic peptide , an exclusively specific *inhibitor* of [calpain] , into the cells also reduced the down-regulation , suggesting the involvement of calpain among all the intracellular cysteine proteases in this process . Negative_regulation CAPN8 CAST 7585879 325603 I preferentially *inhibits* micro ( mu ) [-calpain] while inhibitor II inhibits milli ( m)-calpain . Negative_regulation CAPN8 CAST 7709342 298000 The Milan hypertensive strain (MHS) of rats , in addition to having hypertension , is also characterized by a genetic deficiency in , the endogenous *inhibitor* of [calpain] . Negative_regulation CAPN8 CAST 7847693 286645 Immunoreactivity toward , the endogenous *inhibitor* of [calpain] , was also markedly reduced in layers II-V of the neocortex in Alzheimer 's disease . Negative_regulation CAPN8 CAST 8082870 271069 It is concluded that a remarkable decrease in content maintained unchanged whole liver soluble homogenate calpain activity during protein depletion and refeeding and *contributes* to an increased [calpain] activity related to degradable protein in depleted livers . Negative_regulation CAPN8 CAST 8149403 252761 The decline of the pump activity corresponded to the degradation of the pump protein and was inversely correlated to the amount of the natural *inhibitor* of [calpain] , , present in the cells . Negative_regulation CAPN8 CAST 8334520 223760 The immunohistochemical localization of , an endogenous *inhibitor* of both m- and [mu-calpain] was also examined . Negative_regulation CAPN8 CAST 8373185 229654 A peptide containing the inhibitory sequence did not *inhibit* the binding of [calpain] to membranes . Negative_regulation CAPN8 CAST 8373185 229668 These data indicate that calpain binds to cell membranes through a site ( regulatory site ) other than the active site and that *inhibits* the binding of [calpain] to cell membranes via a site ( regulatory inhibition site ) other than the inhibitory sequence . Negative_regulation CAPN8 CAST 8410223 233505 In addition , the activity of , an intrinsic *inhibitor* of [calpain] , in the basilar artery was determined by assay . Negative_regulation CAPN8 CAST 8946415 400411 The present experiments were concerned with the examination of the hypothesis that a deficiency in , the endogenous *inhibitor* of [calpain] , enhances learning and memory performance . Negative_regulation CAPN8 CAST 9046025 416686 We concluded that a decrease in content *contributes* to an increased [calpain] activity related to degradable protein in protein depleted kidney . Negative_regulation CAPN8 CAST 9116760 406469 , an endogenous calpain inhibitor , *inhibits* not only the proteolytic activity of calpain but also the binding of [calpain] to membranes . Negative_regulation CAPN8 CAST 9207214 440710 In this study , we investigated whether mu-calpain is involved in the processing of profilaggrin to filaggrin monomers by using both an active mu-calpain specific antibody and a 27-mer synthetic peptide , a cell-permeable [calpain-specific] *inhibitor* . Negative_regulation CAPN8 CAST 9369979 464117 The inhibitory activity of calpastatin also tended to decrease after HI , indicating that a reduction of may be *necessary* for extensive [calpain] activation to occur . Negative_regulation CAPN8 CAST 9426288 481635 Characterization of the factor in cytoplasm revealed that it is likely to be , an endogenous *inhibitor* of [calpain] ( Ca2+ activated neutral protease ) . Negative_regulation CAPN8 CAST 9838106 552604 Previous studies have shown that transcription of the gene encoding bovine , an *inhibitor* of the calcium activated cysteine protease [calpain] , is upregulated following activation of cAMP dependent signaling pathways . Negative_regulation CAPN8 CAST 9894609 558759 In the present study , the physiological *inhibitor* of [calpain] , , was found to be cleaved in three different apoptotic systems . Negative_regulation CAPN8 CAST 9990015 597214 Exposure of preadipocytes to the calpain inhibitor N-acetyl-Leu-Leu-norleucinal or overexpression of , a specific endogenous *inhibitor* of [calpain] , blocks expression of adipocyte-specific genes , notably the CCAAT/enhancer binding protein ( C/EBP)alpha gene , and acquisition of the adipocyte phenotype . Negative_regulation CAPN8 CD3EAP 22206846 2575069 We also determined that the mediated *inhibition* of [calpain] activity in the brain is greater in the CAST mice with Aß pathology than in non-APP tg mice , as demonstrated by a decrease in calpain mediated cytoskeleton protein cleavage . Negative_regulation CAPN8 CD3EAP 22206846 2575083 In summary , in vivo [calpain] inhibition *mediated* by transgene expression reduces Aß pathology in APP23 mice , with our findings further suggesting that APP metabolism is modified by CAST overexpression as the mice develop Aß pathology . Negative_regulation CAPN8 CDC42 12649322 1072325 Further , both [calpain] inhibition and stimulation with IL-8 and formyl-Met-Leu-Phe ( fMLP ) *induced* an increase in and Rac activation . Negative_regulation CAPN8 CEP104 11331414 808693 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP112 11331414 808705 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP120 11331414 808703 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP128 11331414 808691 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP135 11331414 808709 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP152 11331414 808711 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP164 11331414 808710 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP170 11331414 808706 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP19 11331414 808704 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP192 11331414 808696 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP250 11331414 808690 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP290 11331414 808707 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP350 11331414 808692 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP41 11331414 808689 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP44 11331414 808712 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP55 11331414 808688 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP57 11331414 808714 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP63 11331414 808700 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP68 11331414 808708 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP70 11331414 808713 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP72 11331414 808697 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP76 11331414 808698 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP78 11331414 808699 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP85 11331414 808695 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP89 11331414 808701 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP95 11331414 808694 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CEP97 11331414 808702 also blocked Abeta-induction of cyclin D1 and DP5 genes and *blocked* Abeta induced increases in cytoplasmic cytochrome c , caspase 3-like activity and [calpain] activation . Negative_regulation CAPN8 CHGA 12171431 974156 Therefore it is suggested that *caused* a reduction of the proteolysis of myofibrillar protein in skeletal muscles through a reduction of [calpain] and proteasome activities , in consequence to ameliorate the muscle atrophy . Negative_regulation CAPN8 CHN2 8424777 210905 Two irreversible [calpain] *inhibitors* , benzyloxycarbonyl ( Cbz ) -Leu-Leu-Tyr-Ch2F and , were shown earlier [ Anagli , Hagmann and Shaw ( 1991 ) Biochem . Negative_regulation CAPN8 CHN2 8566604 349476 The protease inhibitor *inhibited* both [calpain-like] protease activity and induction of the MMPT by Ca2+ and tert-butyl hydroperoxide . Negative_regulation CAPN8 CHN2 9018111 412185 The effect of a [calpain-selective] cell permeant *inhibitor* , benzyloxycarbonyl Leu-Leu-Tyr diazomethylketone ( ) , on the serum stimulated growth of WI-38 human fibroblasts has been investigated . Negative_regulation CAPN8 CHN2 9103432 423245 in this study , we show that two additional [calpain] active site *inhibitors* , L-3-carboxy-trans-2,3-epoxypropionyl-leu-amido- ( 4-guanidinio ) butane ethyl ester ( E64d ) and carbenzoxy-leu-leu-tyr-CHN2 ( ) , also prevent apoptosis in this model . Negative_regulation CAPN8 CPN2 18455725 1921322 Our findings introduce the possibility that reversible phosphorylation of *regulates* its ability to activate [calpain] in phosphatase inhibitor induced apoptosis and controls the cellular accessibility of long-chain fatty acid-CoAs for cellular signaling . Negative_regulation CAPN8 CSE 15180919 1288656 Transfection of PAEC with antisense oligodeoxyribonucleotides of calpastatin , the major endogenous calpain inhibitor , prevented *induced* increase in calpastatin protein content and CSE induced decreases in [calpain] activity . Negative_regulation CAPN8 CSE 16100081 1466564 Incubation of PAEC with an antisense oligodeoxyribonucleotide of calpastatin prevented CSE induced increases in calpastatin protein and *induced* decreases in [calpain] activity , eNOS gene transcription , activity and protein content of eNOS , and NO release . Negative_regulation CAPN8 CXCL17 16091365 1460711 Rather than inhibiting microglial activation and caspase , CTC and *suppressed* [calpain] activities . Negative_regulation CAPN8 EGFR 21656832 2442412 Loss of also *increased* the activity of [calpain] , which is pro-apoptotic . Negative_regulation CAPN8 FGF1 9067861 418891 In contrast , both acidic and basic FGF stimulated mu calpain ( 37 % ) and mcalpain ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 FGF10 9067861 418892 In contrast , both acidic and basic FGF stimulated mu calpain ( 37 % ) and mcalpain ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 FGF11 9067861 418893 In contrast , both acidic and basic FGF stimulated mu calpain ( 37 % ) and mcalpain ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 FGF12 9067861 418894 In contrast , both acidic and basic FGF stimulated mu calpain ( 37 % ) and mcalpain ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 FGF13 9067861 418895 In contrast , both acidic and basic FGF stimulated mu calpain ( 37 % ) and mcalpain ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 FGF14 9067861 418896 In contrast , both acidic and basic FGF stimulated mu calpain ( 37 % ) and mcalpain ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 FGF16 9067861 418897 In contrast , both acidic and basic FGF stimulated mu calpain ( 37 % ) and mcalpain ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 FGF17 9067861 418898 In contrast , both acidic and basic FGF stimulated mu calpain ( 37 % ) and mcalpain ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 FGF18 9067861 418899 In contrast , both acidic and basic FGF stimulated mu calpain ( 37 % ) and mcalpain ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 FGF19 9067861 418900 In contrast , both acidic and basic FGF stimulated mu calpain ( 37 % ) and mcalpain ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 FGF2 9067861 418901 In contrast , both acidic and basic FGF stimulated mu calpain ( 37 % ) and mcalpain ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 FGF2 9089209 421796 The intensity of the cytoplasmic calpain immunoreactivity was significantly decreased in the nuclear and non-nuclear regions of the cytoplasm , respectively , following withdrawal of cAMP at 144 hr. Removal of from the medium *resulted* in an increase of cytoplasmic [calpain] immunoreactivity in the nuclear regions and cytoplasm , while there was dramatic loss of myelin calpain immunoreactivity from both the nuclear region and cytoplasm . Negative_regulation CAPN8 FGF20 9067861 418902 In contrast , both acidic and basic FGF stimulated mu calpain ( 37 % ) and mcalpain ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 FGF21 9067861 418903 In contrast , both acidic and basic FGF stimulated mu calpain ( 37 % ) and mcalpain ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 FGF22 9067861 418904 In contrast , both acidic and basic FGF stimulated mu calpain ( 37 % ) and mcalpain ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 FGF23 9067861 418905 In contrast , both acidic and basic FGF stimulated mu calpain ( 37 % ) and mcalpain ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 FGF3 9067861 418906 In contrast , both acidic and basic FGF stimulated mu calpain ( 37 % ) and mcalpain ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 FGF4 9067861 418907 In contrast , both acidic and basic FGF stimulated mu calpain ( 37 % ) and mcalpain ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 FGF5 9067861 418908 In contrast , both acidic and basic FGF stimulated mu calpain ( 37 % ) and mcalpain ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 FGF6 9067861 418909 In contrast , both acidic and basic FGF stimulated mu calpain ( 37 % ) and mcalpain ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 FGF7 9067861 418910 In contrast , both acidic and basic FGF stimulated mu calpain ( 37 % ) and mcalpain ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 FGF8 9067861 418911 In contrast , both acidic and basic FGF stimulated mu calpain ( 37 % ) and mcalpain ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 FGF9 9067861 418912 In contrast , both acidic and basic FGF stimulated mu calpain ( 37 % ) and mcalpain ( 58 % ) of tSC while PDGF-aa and PDGF-bb *inhibited* both [calpain] activities . Negative_regulation CAPN8 FLNA 20937704 2337837 Moreover , down-regulation *enhanced* [calpain] activity through the mitogen activated protein kinase-extracellular signal regulated kinase cascade and stimulated the cleavage of FA proteins . Negative_regulation CAPN8 GAP43 17326767 1747852 A GAP-43 fragment , lacking about forty N-terminal residues ( named GAP-43-3 ) , was produced by m-calpain mediated cleavage of and *inhibited* m-calpain , but not [micro-calpain] . Negative_regulation CAPN8 GAS2 20679491 2317403 *inhibits* [calpain] protease activity , and beta-catenin is a calpain substrate in these cells . Negative_regulation CAPN8 GIF 22664727 2632761 These findings suggest that berbamine confers cardioprotection against I/R injury by attenuating [ Ca ( 2+ ) ( i ) overloading and *preventing* [calpain] activation through the activation of the PI3K-Akt-GSK3ß pathway and , subsequently , opening of the mitoK ( ATP ) channel . Negative_regulation CAPN8 GPER1 9207214 440711 In this study , we investigated whether mu-calpain is involved in the processing of profilaggrin to filaggrin monomers by using both an active mu-calpain specific antibody and a <27-mer> synthetic calpastatin peptide , a cell-permeable [calpain-specific] *inhibitor* . Negative_regulation CAPN8 HMOX1 21352351 2579169 Puerarin protects human umbilical vein endothelial cells against high glucose induced apoptosis by upregulating and *inhibiting* [calpain] activation . Negative_regulation CAPN8 IL2RB 15264225 1275147 NGF acts via low-affinity neurotrophin receptor and [calpain] *inhibition* to reduce UV neurotoxicity . Negative_regulation CAPN8 ITGB1 16894473 1597260 ( 1A ) decreased the Skp2 expression and *repressed* the activity of [calpain] during G1 phase in SMMC-7721 cells . Negative_regulation CAPN8 ITGB2 16894473 1597261 ( 1A ) decreased the Skp2 expression and *repressed* the activity of [calpain] during G1 phase in SMMC-7721 cells . Negative_regulation CAPN8 ITGB3 16894473 1597262 ( 1A ) decreased the Skp2 expression and *repressed* the activity of [calpain] during G1 phase in SMMC-7721 cells . Negative_regulation CAPN8 ITGB4 16894473 1597263 ( 1A ) decreased the Skp2 expression and *repressed* the activity of [calpain] during G1 phase in SMMC-7721 cells . Negative_regulation CAPN8 ITGB5 16894473 1597264 ( 1A ) decreased the Skp2 expression and *repressed* the activity of [calpain] during G1 phase in SMMC-7721 cells . Negative_regulation CAPN8 ITGB6 16894473 1597265 ( 1A ) decreased the Skp2 expression and *repressed* the activity of [calpain] during G1 phase in SMMC-7721 cells . Negative_regulation CAPN8 ITGB7 16894473 1597266 ( 1A ) decreased the Skp2 expression and *repressed* the activity of [calpain] during G1 phase in SMMC-7721 cells . Negative_regulation CAPN8 ITGB8 16894473 1597267 ( 1A ) decreased the Skp2 expression and *repressed* the activity of [calpain] during G1 phase in SMMC-7721 cells . Negative_regulation CAPN8 KHSRP 15264225 1275214 Overall , we interpret these results as consistent with an NGF neuroprotective pathway wherein activation *leads* sequentially to ceramide generation , new protein synthesis , and inhibition of [calpain] activation . Negative_regulation CAPN8 KNG1 2396995 141384 We explored the kinetic mechanisms for *inhibition* of [calpain] by comparing calpain inactivation by human high-molecular-mass kininogen ( HK ) and human low-molecular-mass kininogen ( LK ) . Negative_regulation CAPN8 KNG1 2433279 69345 The 2B5 antibody did neutralize the ability of to *inhibit* platelet [calpain] . Negative_regulation CAPN8 KNG1 2473540 113877 Since low molecular weight can also *inhibit* [calpain] , the coagulant activity of kininogen , an activity unique for high molecular weight kininogen , was determined in dystrophic hamster plasma and found to be 69 % of normal in close agreement with the calpain inhibitory activity . Negative_regulation CAPN8 LGALS3 21368866 2361315 Here , we report that inhibition by siRNA or GCS-100/MCP *enhances* [calpain] activation , whereas Gal-3 overexpression inhibits it . Negative_regulation CAPN8 LPA 20420580 2246712 Interestingly , induced down-regulation of MAG was significantly inhibited by calpain inhibitors ( calpain inhibitor X , E-64 and E-64d ) and LPA markedly *induced* [calpain] activation in the DR . Negative_regulation CAPN8 MAG 20420580 2246713 Interestingly , LPA induced down-regulation of was significantly inhibited by calpain inhibitors ( calpain inhibitor X , E-64 and E-64d ) and LPA markedly *induced* [calpain] activation in the DR . Negative_regulation CAPN8 MAPK1 20089917 2201484 In both cell types , BDNF and EGF rapidly elicited [calpain] activation , which was completely *blocked* by and calpain inhibitors . Negative_regulation CAPN8 MAPK10 20089917 2201485 In both cell types , BDNF and EGF rapidly elicited [calpain] activation , which was completely *blocked* by and calpain inhibitors . Negative_regulation CAPN8 MAPK11 20089917 2201486 In both cell types , BDNF and EGF rapidly elicited [calpain] activation , which was completely *blocked* by and calpain inhibitors . Negative_regulation CAPN8 MAPK12 20089917 2201487 In both cell types , BDNF and EGF rapidly elicited [calpain] activation , which was completely *blocked* by and calpain inhibitors . Negative_regulation CAPN8 MAPK13 20089917 2201488 In both cell types , BDNF and EGF rapidly elicited [calpain] activation , which was completely *blocked* by and calpain inhibitors . Negative_regulation CAPN8 MAPK14 20089917 2201489 In both cell types , BDNF and EGF rapidly elicited [calpain] activation , which was completely *blocked* by and calpain inhibitors . Negative_regulation CAPN8 MAPK15 20089917 2201483 In both cell types , BDNF and EGF rapidly elicited [calpain] activation , which was completely *blocked* by and calpain inhibitors . Negative_regulation CAPN8 MAPK3 20089917 2201490 In both cell types , BDNF and EGF rapidly elicited [calpain] activation , which was completely *blocked* by and calpain inhibitors . Negative_regulation CAPN8 MAPK4 20089917 2201491 In both cell types , BDNF and EGF rapidly elicited [calpain] activation , which was completely *blocked* by and calpain inhibitors . Negative_regulation CAPN8 MAPK6 20089917 2201492 In both cell types , BDNF and EGF rapidly elicited [calpain] activation , which was completely *blocked* by and calpain inhibitors . Negative_regulation CAPN8 MAPK7 20089917 2201493 In both cell types , BDNF and EGF rapidly elicited [calpain] activation , which was completely *blocked* by and calpain inhibitors . Negative_regulation CAPN8 MAPK8 20089917 2201494 In both cell types , BDNF and EGF rapidly elicited [calpain] activation , which was completely *blocked* by and calpain inhibitors . Negative_regulation CAPN8 MAPK9 20089917 2201495 In both cell types , BDNF and EGF rapidly elicited [calpain] activation , which was completely *blocked* by and calpain inhibitors . Negative_regulation CAPN8 MAPK9 21156791 2390342 Mechanistically , we observed Fmod to delay the degradation of I?Ba by promoting the following : ( i ) activation of *inhibition* of [calpain] and casein kinase 2 activity ; Negative_regulation CAPN8 NA 15886234 1439831 The presence of PGE2 stimulated calpain activity , whereas two [calpain] *inhibitors* , calpastatin and , blocked EVT migration . Negative_regulation CAPN8 NA 24192288 2891598 Pretreatment of animals with two [calpain] *inhibitors* , and calpeptin , as well as a protein synthesis inhibitor , cycloheximide ( CHX ) , significantly suppressed the IPR induced AQP5 degradation in the PG membrane fraction ; Negative_regulation CAPN8 NGF 2555371 122046 These studies suggest that *causes* a decrease in the activity of [calpain] in morphologically differentiating PC12 cells by causing an increase in the activity of calpastatin . Negative_regulation CAPN8 NOX1 19379762 2089136 Inhibiting or scavenging ROS *attenuated* [calpain] activity and decreased apoptosis in PMEC during septic plasma stimulation . Negative_regulation CAPN8 NOX3 19379762 2089137 Inhibiting or scavenging ROS *attenuated* [calpain] activity and decreased apoptosis in PMEC during septic plasma stimulation . Negative_regulation CAPN8 NOX4 19379762 2089138 Inhibiting or scavenging ROS *attenuated* [calpain] activity and decreased apoptosis in PMEC during septic plasma stimulation . Negative_regulation CAPN8 NOX5 19379762 2089135 Inhibiting or scavenging ROS *attenuated* [calpain] activity and decreased apoptosis in PMEC during septic plasma stimulation . Negative_regulation CAPN8 NPY4R 16385561 1520110 The restoration of pCREB by protein inhibitors or the *inhibition* of excessive activation of [calpain] by calpain inhibitor did not reduce OGD/reoxygenation induced LDH release . Negative_regulation CAPN8 NPY4R 17428797 1742332 Interestingly , we found that the [calpain] regulation of AMPAR currents was diminished by inhibition of Ca2+/calmodulin dependent protein kinase II ( CaMKII ) but was *augmented* by inhibition of protein . Negative_regulation CAPN8 NPY6R 16385561 1520109 The restoration of pCREB by protein inhibitors or the *inhibition* of excessive activation of [calpain] by calpain inhibitor did not reduce OGD/reoxygenation induced LDH release . Negative_regulation CAPN8 NTF3 15264225 1275148 NGF acts via p75 low-affinity receptor and [calpain] *inhibition* to reduce UV neurotoxicity . Negative_regulation CAPN8 NTF4 15264225 1275149 NGF acts via p75 low-affinity receptor and [calpain] *inhibition* to reduce UV neurotoxicity . Negative_regulation CAPN8 PGP 10493948 646868 These results indicated that calpain involved Pgp turnover and that [calpain] inhibition *induced* ubiquitinated mainly at the cell surface membrane with a reduction in its own functions suggesting that the modulation of Pgp-turnover involves MDR-reversal by another approach . Negative_regulation CAPN8 PRKACB 11909964 924005 EGF induced [calpain] activation was *inhibited* by cAMP activation of , as the PKA inhibitors H-89 and Rp-8Br-cAMPS abrogated cAMP inhibition of both motility and calpain activation . Negative_regulation CAPN8 PRKACB 15364618 1294339 The effects of IPC on calpain , alpha-fodrin , and LDH release were blunted by the application of the PKA inhibitor H89 or alprenolol during IPC , while transient stimulation of with CPT-cAMP or isoproterenol before ischemia *attenuated* [calpain] activation , alpha-fodrin degradation , and markedly reduced LDH release ( P < 0.001 ) . Negative_regulation CAPN8 PRKACB 19642365 2113453 The actin binding protein (ABP) and talin proteolysis demonstrated that [calpain] was *activated* by inhibitor and expressed on the platelet membrane . Negative_regulation CAPN8 PRKACG 11909964 924006 EGF induced [calpain] activation was *inhibited* by cAMP activation of , as the PKA inhibitors H-89 and Rp-8Br-cAMPS abrogated cAMP inhibition of both motility and calpain activation . Negative_regulation CAPN8 PRKACG 15364618 1294340 The effects of IPC on calpain , alpha-fodrin , and LDH release were blunted by the application of the PKA inhibitor H89 or alprenolol during IPC , while transient stimulation of with CPT-cAMP or isoproterenol before ischemia *attenuated* [calpain] activation , alpha-fodrin degradation , and markedly reduced LDH release ( P < 0.001 ) . Negative_regulation CAPN8 PRKACG 19642365 2113454 The actin binding protein (ABP) and talin proteolysis demonstrated that [calpain] was *activated* by inhibitor and expressed on the platelet membrane . Negative_regulation CAPN8 PRKAR1A 11909964 924007 EGF induced [calpain] activation was *inhibited* by cAMP activation of , as the PKA inhibitors H-89 and Rp-8Br-cAMPS abrogated cAMP inhibition of both motility and calpain activation . Negative_regulation CAPN8 PRKAR1A 15364618 1294341 The effects of IPC on calpain , alpha-fodrin , and LDH release were blunted by the application of the PKA inhibitor H89 or alprenolol during IPC , while transient stimulation of with CPT-cAMP or isoproterenol before ischemia *attenuated* [calpain] activation , alpha-fodrin degradation , and markedly reduced LDH release ( P < 0.001 ) . Negative_regulation CAPN8 PRKAR1A 19642365 2113455 The actin binding protein (ABP) and talin proteolysis demonstrated that [calpain] was *activated* by inhibitor and expressed on the platelet membrane . Negative_regulation CAPN8 PRKAR1B 11909964 924008 EGF induced [calpain] activation was *inhibited* by cAMP activation of , as the PKA inhibitors H-89 and Rp-8Br-cAMPS abrogated cAMP inhibition of both motility and calpain activation . Negative_regulation CAPN8 PRKAR1B 15364618 1294342 The effects of IPC on calpain , alpha-fodrin , and LDH release were blunted by the application of the PKA inhibitor H89 or alprenolol during IPC , while transient stimulation of with CPT-cAMP or isoproterenol before ischemia *attenuated* [calpain] activation , alpha-fodrin degradation , and markedly reduced LDH release ( P < 0.001 ) . Negative_regulation CAPN8 PRKAR1B 19642365 2113456 The actin binding protein (ABP) and talin proteolysis demonstrated that [calpain] was *activated* by inhibitor and expressed on the platelet membrane . Negative_regulation CAPN8 PRKAR2A 11909964 924009 EGF induced [calpain] activation was *inhibited* by cAMP activation of , as the PKA inhibitors H-89 and Rp-8Br-cAMPS abrogated cAMP inhibition of both motility and calpain activation . Negative_regulation CAPN8 PRKAR2A 15364618 1294343 The effects of IPC on calpain , alpha-fodrin , and LDH release were blunted by the application of the PKA inhibitor H89 or alprenolol during IPC , while transient stimulation of with CPT-cAMP or isoproterenol before ischemia *attenuated* [calpain] activation , alpha-fodrin degradation , and markedly reduced LDH release ( P < 0.001 ) . Negative_regulation CAPN8 PRKAR2A 19642365 2113457 The actin binding protein (ABP) and talin proteolysis demonstrated that [calpain] was *activated* by inhibitor and expressed on the platelet membrane . Negative_regulation CAPN8 PRKAR2B 11909964 924010 EGF induced [calpain] activation was *inhibited* by cAMP activation of , as the PKA inhibitors H-89 and Rp-8Br-cAMPS abrogated cAMP inhibition of both motility and calpain activation . Negative_regulation CAPN8 PRKAR2B 15364618 1294344 The effects of IPC on calpain , alpha-fodrin , and LDH release were blunted by the application of the PKA inhibitor H89 or alprenolol during IPC , while transient stimulation of with CPT-cAMP or isoproterenol before ischemia *attenuated* [calpain] activation , alpha-fodrin degradation , and markedly reduced LDH release ( P < 0.001 ) . Negative_regulation CAPN8 PRKAR2B 19642365 2113458 The actin binding protein (ABP) and talin proteolysis demonstrated that [calpain] was *activated* by inhibitor and expressed on the platelet membrane . Negative_regulation CAPN8 PSEN1 10677567 668267 When PS and [calpain] were separately expressed in COS cells by cDNA transfection and then combined in vitro , or both were co-transfected to be co-expressed in vivo in COS cells , and PS2 *reduced* the casein proteolysis activity of m-calpain but not that of mu-calpain . Negative_regulation CAPN8 PTH 8546814 326495 production by micro-calpain , expressed as per cent area under the curve , *increased* from 0 % in the absence of either [micro-calpain] or Ca2+ , to 71.5 % when a 5 : 1 molar ratio of bPTH to calpain was used . Negative_regulation CAPN8 PTX3 21723247 2461145 Here , we show that various [calpain] inhibitors ( PD150606 , PD151746 , N-acetyl-Leu-Leu-Nle-CHO [ ALLN ] , N-acetyl-Leu-Leu-Met-CHO [ ALLM ] , and calpeptin ) and ?-secretase inhibitor I *induced* increase in cytoplasmic free Ca ( 2+ ) ( [ Ca ( 2+ ) ] ( i ) ) in human neutrophils and neutrophil migration . Negative_regulation CAPN8 PTX4 21723247 2461144 Here , we show that various [calpain] inhibitors ( PD150606 , PD151746 , N-acetyl-Leu-Leu-Nle-CHO [ ALLN ] , N-acetyl-Leu-Leu-Met-CHO [ ALLM ] , and calpeptin ) and ?-secretase inhibitor I *induced* increase in cytoplasmic free Ca ( 2+ ) ( [ Ca ( 2+ ) ] ( i ) ) in human neutrophils and neutrophil migration . Negative_regulation CAPN8 RAC1 12649322 1072326 Further , both [calpain] inhibition and stimulation with IL-8 and formyl-Met-Leu-Phe ( fMLP ) *induced* an increase in Cdc42 and activation . Negative_regulation CAPN8 RAC2 12649322 1072327 Further , both [calpain] inhibition and stimulation with IL-8 and formyl-Met-Leu-Phe ( fMLP ) *induced* an increase in Cdc42 and activation . Negative_regulation CAPN8 RAC3 12649322 1072328 Further , both [calpain] inhibition and stimulation with IL-8 and formyl-Met-Leu-Phe ( fMLP ) *induced* an increase in Cdc42 and activation . Negative_regulation CAPN8 RAPSN 17640526 1771150 Interestingly , the AChR associated protein interacted with calpain in an agrin dependent manner , and this interaction *inhibited* the protease activity of [calpain] . Negative_regulation CAPN8 RBMS1 23922702 2826322 In addition , ( 1 , 10 µM ) significantly *blocked* Aß25-35 induced [µ-calpain] expression and decreased the formation of p25 and tau hyperphosphorylation . Negative_regulation CAPN8 SERPINA1 23526215 2803998 Furthermore , *inhibited* [calpain] activity , whose activation by TNF-a contributed to decreased intracellular A1AT concentrations . Negative_regulation CAPN8 SST 10601241 574285 Evidence for the involvement of calpain inhibition in this process was obtained by the demonstration that 1 ) *induced* a dose dependent decrease in [calpain] activity and 2 ) calpain inhibitors , calpain inhibitor I and calpeptin , both abolished the cleavage of Hsp 90 and induced a dose dependent increase in [ ( 3 ) H ] dexamethasone binding . Negative_regulation CAPN8 SYK 23684705 2811134 The activity of [calpain] in MCF7 cell lysates was *inhibited* by both treatment with hydrogen peroxide and expression of , the former due to oxidative inactivation of calpain and the latter to enhanced expression of calpastatin (CAST) , the endogenous calpain inhibitor . Negative_regulation CAPN8 TAT 22525374 2658657 Inhibition of the mPTP pore with peptide , [calpain] *inhibition* with PD150606 , or knockdown ( KD ) of Bnip3 failed to prevent nuclear translocation of these DNase although Bnip3 KD blocked mitochondrial fission . Negative_regulation CAPN8 TDGF1P6 15210718 1289074 In summary , we report for the first time that both caspases and calpains are involved in 661W photoreceptor apoptosis and that [calpain] activation can be *prevented* by the ROS scavenger . Negative_regulation CAPN8 TNS1 7816056 285300 For control myofibrils , both 100 and 200 uM , *reduced* [calpain] degradation rates to a similar extent for all substrate proteins . Negative_regulation CAPN8 TYR 8424777 210904 Two irreversible [calpain] *inhibitors* , benzyloxycarbonyl ( Cbz ) <-Leu-Leu-Tyr-Ch2F> and Cbz-Leu-Leu-Tyr-CHN2 , were shown earlier [ Anagli , Hagmann and Shaw ( 1991 ) Biochem . Negative_regulation CAPN8 TYR 8566604 349475 The protease inhibitor *inhibited* both [calpain-like] protease activity and induction of the MMPT by Ca2+ and tert-butyl hydroperoxide . Negative_regulation CAPN9 CABP4 12072431 976023 Interestingly , ectopic expression of a , calbindin-D(28k) , in MCF-7 cells not only *attenuated* the elevation in [ Ca ( 2+ ) ] ( i ) and [calpain] activation , but also reduced death triggered by vitamin D compounds . Negative_regulation CAPN9 ITGB2 16894473 1597269 ( 1A ) decreased the Skp2 expression and *repressed* the activity of [calpain] during G1 phase in SMMC-7721 cells . Negative_regulation CAPN9 TNS1 7816056 285301 For control myofibrils , both 100 and 200 uM , *reduced* [calpain] degradation rates to a similar extent for all substrate proteins . Negative_regulation CAPNS1 CAPN8 16956607 1639548 This suggested that LSEAL had a inhibitory function and synthetic LSEAL *inhibited* [calpain I] and II proteolysis of two calpain substrates , tau and alpha-synuclein . Negative_regulation CAPS IL1B 19501000 2098117 The central *role* of in [CAPS] is supported by the response to IL-1 targeted therapy . Negative_regulation CAPS IL1B 19649332 2118958 Kineret ( R ) or anakinra/ Amgen , Inc. ) , not only provided supportive evidence for the *role* of in [CAPS] but also demonstrated the efficacy of targeting IL-1beta for treatment of these conditions . Negative_regulation CAPS IL1B 19707454 2009176 The selective blockade of IL-1beta , with anakinra ( IL-1 receptor antagonist ) , not only provided supportive evidence for the *role* of in [CAPS] , but also demonstrated the efficacy of targeting IL-1beta for treatment of these conditions . Negative_regulation CASP1 CAPN8 11449356 835975 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Negative_regulation CASP1 CAPN8 12199150 982410 Staurosporine induced loss of neuronal particles was blocked by nonselective [caspase] inhibition ( z-VAD-fmk ) and by *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CASP1 CAPN8 20080185 2225815 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known [caspase] inhibitor Z-VAD fmk or by *inhibition* . Negative_regulation CASP1 EPHB2 11854398 913636 Concomitantly , we have also demonstrated that recombinant Mos , MEK , and are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP1 EPHB2 14720214 1197750 Interestingly , inhibition of dramatically increased mitochondrial malfunction , and *enhanced* [caspase] activation , resulting in enhanced neuronal cell death . Negative_regulation CASP1 EPHB2 18490749 1916977 inhibition *led* to cytosolic release of mitochondrial proteins and [caspase] activation . Negative_regulation CASP1 EPHB2 21858143 2469160 Facilitation of activation and *inhibition* of [caspase] activation promotes resistance to Glu excitotoxicity in SCN2.2 cells . Negative_regulation CASP1 EPHB2 22334892 2553977 In response to mutant Htt , is activated and directs a protective transcriptional response and *inhibits* [caspase] activation . Negative_regulation CASP1 FAS 11739185 886054 Fas signaling can be interrupted at 3 mains levels : clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector [caspase] *inhibition* of downstream caspase-8 . Negative_regulation CASP1 FAS 12207331 983574 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Negative_regulation CASP1 FAS 23809162 2808149 Here we show that stimulation of macrophages with ?-3 , including eicosapentaenoic acid ( EPA ) , docosahexaenoic acid ( DHA ) , and other family members , abolished NLRP3 inflammasome activation and *inhibited* subsequent [caspase-1] activation and IL-1ß secretion . Negative_regulation CASP1 MAP2K6 11854398 913642 Concomitantly , we have also demonstrated that recombinant Mos , , and ERK are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP1 MAP2K6 16672322 1583577 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* caspase activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only [caspase] activity . Negative_regulation CASP1 SPHK1 16890416 1607662 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating and *inhibiting* [caspase] activity . Negative_regulation CASP1 TGM2 12667098 1075259 A discussion of the effect of antibodies , [caspase] *inhibitors* , chemical inhibitors , heat-shock proteins , suppressor peptides and inhibitors upon aggregation and disease is presented . Negative_regulation CASP1 TGM2 17003418 1618385 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Negative_regulation CASP1 TNF 22678778 2620927 Experimental models suggest promising role of newer anti-inflammatory drugs such as antioxidants , inhibitors of , poly-ADP-ribose inhibitors , [caspase] *inhibitors* , brain derived neurotrophic factor etc. ; Negative_regulation CASP1 TNF 22933232 2701604 We also evaluated the lipopolysaccharide (LPS)- , IL-1a- , and induced activity of matrix metalloproteinase 3 (MMP-3) , MMP-9 , and MMP-13 in NLRP3-knockout mice and wild-type mice and the *inhibition* of [caspase 1] with Z-YVAD-FMK and the blockade of IL-1ß with IL-1 receptor antagonist (IL-1Ra) . Negative_regulation CASP1 TNFSF10 17908999 1803397 With the use of locked nucleic acid ( LNA ) -antimiR-21 oligonucleotides , bimodal imaging vectors , and neural precursor cells (NPC) expressing a secretable variant of the cytotoxic agent tumor necrosis factor related apoptosis inducing ligand ( S-TRAIL ) , we show that the combined suppression of miR-21 and *leads* to a synergistic increase in [caspase] activity and significantly decreased cell viability in human glioma cells in vitro . Negative_regulation CASP1 TNFSF10 18497982 1917531 *reduced* endogenous TRAIL , Bcl2l1 and [caspase-1] expression . Negative_regulation CASP1 TNFSF10 20951133 2364981 induced loss of cIAP-1 and XIAP *requires* [caspase] activity . Negative_regulation CASP1 TNFSF10 9334376 457888 AICD can be blocked by [ICE] inhibitors in some patients , and this AICD is *mediated* by . Negative_regulation CASP10 CAPN8 11449356 835989 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Negative_regulation CASP10 CAPN8 12199150 982424 Staurosporine induced loss of neuronal particles was blocked by nonselective [caspase] inhibition ( z-VAD-fmk ) and by *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CASP10 CAPN8 20080185 2225829 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known [caspase] inhibitor Z-VAD fmk or by *inhibition* . Negative_regulation CASP10 EPHB2 11854398 913645 Concomitantly , we have also demonstrated that recombinant Mos , MEK , and are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP10 EPHB2 14720214 1197751 Interestingly , inhibition of dramatically increased mitochondrial malfunction , and *enhanced* [caspase] activation , resulting in enhanced neuronal cell death . Negative_regulation CASP10 EPHB2 18490749 1916978 inhibition *led* to cytosolic release of mitochondrial proteins and [caspase] activation . Negative_regulation CASP10 EPHB2 21858143 2469161 Facilitation of activation and *inhibition* of [caspase] activation promotes resistance to Glu excitotoxicity in SCN2.2 cells . Negative_regulation CASP10 EPHB2 22334892 2553979 In response to mutant Htt , is activated and directs a protective transcriptional response and *inhibits* [caspase] activation . Negative_regulation CASP10 FAS 11739185 886055 Fas signaling can be interrupted at 3 mains levels : clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector [caspase] *inhibition* of downstream caspase-8 . Negative_regulation CASP10 FAS 12207331 983575 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Negative_regulation CASP10 MAP2K6 11854398 913651 Concomitantly , we have also demonstrated that recombinant Mos , , and ERK are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP10 MAP2K6 16672322 1583585 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* caspase activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only [caspase] activity . Negative_regulation CASP10 SPHK1 16890416 1607664 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating and *inhibiting* [caspase] activity . Negative_regulation CASP10 TGM2 12667098 1075266 A discussion of the effect of antibodies , [caspase] *inhibitors* , chemical inhibitors , heat-shock proteins , suppressor peptides and inhibitors upon aggregation and disease is presented . Negative_regulation CASP10 TGM2 17003418 1618392 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Negative_regulation CASP10 TNF 22678778 2620928 Experimental models suggest promising role of newer anti-inflammatory drugs such as antioxidants , inhibitors of , poly-ADP-ribose inhibitors , [caspase] *inhibitors* , brain derived neurotrophic factor etc. ; Negative_regulation CASP10 TNFSF10 17908999 1803404 With the use of locked nucleic acid ( LNA ) -antimiR-21 oligonucleotides , bimodal imaging vectors , and neural precursor cells (NPC) expressing a secretable variant of the cytotoxic agent tumor necrosis factor related apoptosis inducing ligand ( S-TRAIL ) , we show that the combined suppression of miR-21 and *leads* to a synergistic increase in [caspase] activity and significantly decreased cell viability in human glioma cells in vitro . Negative_regulation CASP10 TNFSF10 20951133 2364984 induced loss of cIAP-1 and XIAP *requires* [caspase] activity . Negative_regulation CASP12 CAPN8 11449356 836129 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Negative_regulation CASP12 CAPN8 12199150 982590 Staurosporine induced loss of neuronal particles was blocked by nonselective [caspase] inhibition ( z-VAD-fmk ) and by *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CASP12 CAPN8 20080185 2225995 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known [caspase] inhibitor Z-VAD fmk or by *inhibition* . Negative_regulation CASP12 EPHB2 11854398 913735 Concomitantly , we have also demonstrated that recombinant Mos , MEK , and are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP12 EPHB2 14720214 1197761 Interestingly , inhibition of dramatically increased mitochondrial malfunction , and *enhanced* [caspase] activation , resulting in enhanced neuronal cell death . Negative_regulation CASP12 EPHB2 18490749 1916988 inhibition *led* to cytosolic release of mitochondrial proteins and [caspase] activation . Negative_regulation CASP12 EPHB2 21858143 2469171 Facilitation of activation and *inhibition* of [caspase] activation promotes resistance to Glu excitotoxicity in SCN2.2 cells . Negative_regulation CASP12 EPHB2 22334892 2553999 In response to mutant Htt , is activated and directs a protective transcriptional response and *inhibits* [caspase] activation . Negative_regulation CASP12 FAS 11739185 886078 Fas signaling can be interrupted at 3 mains levels : clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector [caspase] *inhibition* of downstream caspase-8 . Negative_regulation CASP12 FAS 12207331 983585 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Negative_regulation CASP12 MAP2K6 11854398 913741 Concomitantly , we have also demonstrated that recombinant Mos , , and ERK are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP12 MAP2K6 16672322 1583665 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* caspase activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only [caspase] activity . Negative_regulation CASP12 SPHK1 16890416 1607697 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating and *inhibiting* [caspase] activity . Negative_regulation CASP12 TGM2 12667098 1075349 A discussion of the effect of antibodies , [caspase] *inhibitors* , chemical inhibitors , heat-shock proteins , suppressor peptides and inhibitors upon aggregation and disease is presented . Negative_regulation CASP12 TGM2 17003418 1618462 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Negative_regulation CASP12 TNF 22678778 2620938 Experimental models suggest promising role of newer anti-inflammatory drugs such as antioxidants , inhibitors of , poly-ADP-ribose inhibitors , [caspase] *inhibitors* , brain derived neurotrophic factor etc. ; Negative_regulation CASP12 TNFSF10 17908999 1803474 With the use of locked nucleic acid ( LNA ) -antimiR-21 oligonucleotides , bimodal imaging vectors , and neural precursor cells (NPC) expressing a secretable variant of the cytotoxic agent tumor necrosis factor related apoptosis inducing ligand ( S-TRAIL ) , we show that the combined suppression of miR-21 and *leads* to a synergistic increase in [caspase] activity and significantly decreased cell viability in human glioma cells in vitro . Negative_regulation CASP12 TNFSF10 20951133 2365014 induced loss of cIAP-1 and XIAP *requires* [caspase] activity . Negative_regulation CASP14 CAPN8 11449356 836003 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Negative_regulation CASP14 CAPN8 12199150 982438 Staurosporine induced loss of neuronal particles was blocked by nonselective [caspase] inhibition ( z-VAD-fmk ) and by *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CASP14 CAPN8 20080185 2225843 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known [caspase] inhibitor Z-VAD fmk or by *inhibition* . Negative_regulation CASP14 EPHB2 11854398 913654 Concomitantly , we have also demonstrated that recombinant Mos , MEK , and are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP14 EPHB2 14720214 1197752 Interestingly , inhibition of dramatically increased mitochondrial malfunction , and *enhanced* [caspase] activation , resulting in enhanced neuronal cell death . Negative_regulation CASP14 EPHB2 18490749 1916979 inhibition *led* to cytosolic release of mitochondrial proteins and [caspase] activation . Negative_regulation CASP14 EPHB2 21858143 2469162 Facilitation of activation and *inhibition* of [caspase] activation promotes resistance to Glu excitotoxicity in SCN2.2 cells . Negative_regulation CASP14 EPHB2 22334892 2553981 In response to mutant Htt , is activated and directs a protective transcriptional response and *inhibits* [caspase] activation . Negative_regulation CASP14 FAS 11739185 886056 Fas signaling can be interrupted at 3 mains levels : clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector [caspase] *inhibition* of downstream caspase-8 . Negative_regulation CASP14 FAS 12207331 983576 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Negative_regulation CASP14 MAP2K6 11854398 913660 Concomitantly , we have also demonstrated that recombinant Mos , , and ERK are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP14 MAP2K6 16672322 1583593 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* caspase activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only [caspase] activity . Negative_regulation CASP14 SPHK1 16890416 1607666 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating and *inhibiting* [caspase] activity . Negative_regulation CASP14 TGM2 12667098 1075273 A discussion of the effect of antibodies , [caspase] *inhibitors* , chemical inhibitors , heat-shock proteins , suppressor peptides and inhibitors upon aggregation and disease is presented . Negative_regulation CASP14 TGM2 17003418 1618399 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Negative_regulation CASP14 TNF 22678778 2620929 Experimental models suggest promising role of newer anti-inflammatory drugs such as antioxidants , inhibitors of , poly-ADP-ribose inhibitors , [caspase] *inhibitors* , brain derived neurotrophic factor etc. ; Negative_regulation CASP14 TNFSF10 17908999 1803411 With the use of locked nucleic acid ( LNA ) -antimiR-21 oligonucleotides , bimodal imaging vectors , and neural precursor cells (NPC) expressing a secretable variant of the cytotoxic agent tumor necrosis factor related apoptosis inducing ligand ( S-TRAIL ) , we show that the combined suppression of miR-21 and *leads* to a synergistic increase in [caspase] activity and significantly decreased cell viability in human glioma cells in vitro . Negative_regulation CASP14 TNFSF10 20951133 2364987 induced loss of cIAP-1 and XIAP *requires* [caspase] activity . Negative_regulation CASP16 CAPN8 11449356 836143 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Negative_regulation CASP16 CAPN8 12199150 982604 Staurosporine induced loss of neuronal particles was blocked by nonselective [caspase] inhibition ( z-VAD-fmk ) and by *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CASP16 CAPN8 20080185 2226009 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known [caspase] inhibitor Z-VAD fmk or by *inhibition* . Negative_regulation CASP16 EPHB2 11854398 913753 Concomitantly , we have also demonstrated that recombinant Mos , MEK , and are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP16 EPHB2 14720214 1197762 Interestingly , inhibition of dramatically increased mitochondrial malfunction , and *enhanced* [caspase] activation , resulting in enhanced neuronal cell death . Negative_regulation CASP16 EPHB2 18490749 1916989 inhibition *led* to cytosolic release of mitochondrial proteins and [caspase] activation . Negative_regulation CASP16 EPHB2 21858143 2469172 Facilitation of activation and *inhibition* of [caspase] activation promotes resistance to Glu excitotoxicity in SCN2.2 cells . Negative_regulation CASP16 EPHB2 22334892 2554001 In response to mutant Htt , is activated and directs a protective transcriptional response and *inhibits* [caspase] activation . Negative_regulation CASP16 FAS 11739185 886079 Fas signaling can be interrupted at 3 mains levels : clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector [caspase] *inhibition* of downstream caspase-8 . Negative_regulation CASP16 FAS 12207331 983586 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Negative_regulation CASP16 MAP2K6 11854398 913759 Concomitantly , we have also demonstrated that recombinant Mos , , and ERK are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP16 MAP2K6 16672322 1583673 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* caspase activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only [caspase] activity . Negative_regulation CASP16 SPHK1 16890416 1607699 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating and *inhibiting* [caspase] activity . Negative_regulation CASP16 TGM2 12667098 1075356 A discussion of the effect of antibodies , [caspase] *inhibitors* , chemical inhibitors , heat-shock proteins , suppressor peptides and inhibitors upon aggregation and disease is presented . Negative_regulation CASP16 TGM2 17003418 1618469 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Negative_regulation CASP16 TNF 22678778 2620939 Experimental models suggest promising role of newer anti-inflammatory drugs such as antioxidants , inhibitors of , poly-ADP-ribose inhibitors , [caspase] *inhibitors* , brain derived neurotrophic factor etc. ; Negative_regulation CASP16 TNFSF10 17908999 1803481 With the use of locked nucleic acid ( LNA ) -antimiR-21 oligonucleotides , bimodal imaging vectors , and neural precursor cells (NPC) expressing a secretable variant of the cytotoxic agent tumor necrosis factor related apoptosis inducing ligand ( S-TRAIL ) , we show that the combined suppression of miR-21 and *leads* to a synergistic increase in [caspase] activity and significantly decreased cell viability in human glioma cells in vitro . Negative_regulation CASP16 TNFSF10 20951133 2365017 induced loss of cIAP-1 and XIAP *requires* [caspase] activity . Negative_regulation CASP2 CAPN8 11449356 836017 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Negative_regulation CASP2 CAPN8 12199150 982452 Staurosporine induced loss of neuronal particles was blocked by nonselective [caspase] inhibition ( z-VAD-fmk ) and by *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CASP2 CAPN8 20080185 2225857 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known [caspase] inhibitor Z-VAD fmk or by *inhibition* . Negative_regulation CASP2 EPHB2 11854398 913663 Concomitantly , we have also demonstrated that recombinant Mos , MEK , and are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP2 EPHB2 14720214 1197753 Interestingly , inhibition of dramatically increased mitochondrial malfunction , and *enhanced* [caspase] activation , resulting in enhanced neuronal cell death . Negative_regulation CASP2 EPHB2 18490749 1916980 inhibition *led* to cytosolic release of mitochondrial proteins and [caspase] activation . Negative_regulation CASP2 EPHB2 21858143 2469163 Facilitation of activation and *inhibition* of [caspase] activation promotes resistance to Glu excitotoxicity in SCN2.2 cells . Negative_regulation CASP2 EPHB2 22334892 2553983 In response to mutant Htt , is activated and directs a protective transcriptional response and *inhibits* [caspase] activation . Negative_regulation CASP2 FAS 11739185 886057 Fas signaling can be interrupted at 3 mains levels : clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector [caspase] *inhibition* of downstream caspase-8 . Negative_regulation CASP2 FAS 12207331 983577 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Negative_regulation CASP2 FAS 9764613 537363 MoAb induced apoptosis of RA synovial cells in vitro , and proinflammatory cytokines tumour necrosis factor-alpha (TNF-alpha) and IL-1beta , but not IL-6 or IL-8 , *inhibited* the anti-Fas induced apoptosis accompanying up-regulation of Bcl-2 protein expression and reduced expression of CPP32 and [ICH-1L] . Negative_regulation CASP2 MAP2K6 11854398 913669 Concomitantly , we have also demonstrated that recombinant Mos , , and ERK are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP2 MAP2K6 16672322 1583601 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* caspase activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only [caspase] activity . Negative_regulation CASP2 SPHK1 16890416 1607668 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating and *inhibiting* [caspase] activity . Negative_regulation CASP2 TGM2 12667098 1075280 A discussion of the effect of antibodies , [caspase] *inhibitors* , chemical inhibitors , heat-shock proteins , suppressor peptides and inhibitors upon aggregation and disease is presented . Negative_regulation CASP2 TGM2 17003418 1618406 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Negative_regulation CASP2 TNF 22678778 2620930 Experimental models suggest promising role of newer anti-inflammatory drugs such as antioxidants , inhibitors of , poly-ADP-ribose inhibitors , [caspase] *inhibitors* , brain derived neurotrophic factor etc. ; Negative_regulation CASP2 TNFSF10 17908999 1803418 With the use of locked nucleic acid ( LNA ) -antimiR-21 oligonucleotides , bimodal imaging vectors , and neural precursor cells (NPC) expressing a secretable variant of the cytotoxic agent tumor necrosis factor related apoptosis inducing ligand ( S-TRAIL ) , we show that the combined suppression of miR-21 and *leads* to a synergistic increase in [caspase] activity and significantly decreased cell viability in human glioma cells in vitro . Negative_regulation CASP2 TNFSF10 20951133 2364990 induced loss of cIAP-1 and XIAP *requires* [caspase] activity . Negative_regulation CASP3 ANGPT1 15692086 1376289 promoted survival of serum starved C2C12 , HSM , and NCM ( MTT , trypan blue ) and *prevented* taxol induced apoptosis ( [caspase-3] ) . Negative_regulation CASP3 ANGPT1 21704119 2465570 Moreover , inhibition *increased* the levels of [active caspase 3] and androsterone , but decreased estradiol , AKT phosphorylation and the area of smooth muscle cell actin . Negative_regulation CASP3 ANGPT1 21738954 2489985 increased cardiomyocyte survival through integrin-ß1 mediated extracellular signal regulated kinase ( ERK ) phosphorylation , which inhibited caspase-9 through phosphorylation at Thr¹²5 and subsequently *reduced* [active caspase-3] . Negative_regulation CASP3 ANGPT1 23554782 2714257 Specifically , *prevented* DOX induced increases in FasL and Bax levels and cleaved [caspase-3] and caspase-8 levels in H9C2 cells . Negative_regulation CASP3 CAPN8 10828077 697058 In the hippocampal neuron cultures , the inhibition of activity *restored* [caspase-3-like] protease activity after an exposure to N-methyl-d-aspartate . Negative_regulation CASP3 CAPN8 11449356 836031 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Negative_regulation CASP3 CAPN8 12199150 982466 Staurosporine induced loss of neuronal particles was blocked by nonselective [caspase] inhibition ( z-VAD-fmk ) and by *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CASP3 CAPN8 12851726 1109693 Furthermore , pretreatment with the specific pharmacological calpain inhibitor calpeptin blocked the drug induced calpain small subunit autolysis and activation in mitochondria and *inhibited* apoptosis associated [caspase-3] activation , demonstrating that mitochondrial calpain activation through small subunit cleavage is an essential step for inducing tumor cell apoptosis by various anticancer drugs . Negative_regulation CASP3 CAPN8 14527821 1148962 [Caspase-3] was also activated by simvastatin after 12 h. Verapamil and PD150606 , a cell-permeable selective calpain inhibitor , significantly *inhibited* simvastatin induced augmentation of activity and blocked caspase-3 activation , respectively . Negative_regulation CASP3 CAPN8 18031600 1828327 SF reduced glutamate evoked apoptotic morphology , [active caspase-3] protein expression , and PARP cleavage and *inhibited* the glutamate induced upregulation of the protein level . Negative_regulation CASP3 CAPN8 20080185 2225871 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known [caspase] inhibitor Z-VAD fmk or by *inhibition* . Negative_regulation CASP3 CAPN8 22237475 2569300 Amiloride also inhibited and calcineurin expression levels in acid induced chondrocytes , and *inhibited* [caspase-3] activity . Negative_regulation CASP3 CAPN8 22720745 2713464 The findings of this investigation show that *prevented* the activation of [caspase-3] , whereas caspase-3 appeared to enhance the calpain activity during post-mortem aging through inhibition of calpastatin . Negative_regulation CASP3 CCND1 18228136 2010121 In conclusion , 2ME chemosensitizes resistant breast cancer cells to Dox cytotoxicity by down regulating expression of Bcl2 and , *augmenting* [caspase 3] activity as well as inducing cell cycle block in G ( 1 ) and S phases . Negative_regulation CASP3 CCND1 24360936 2911199 In addition , analogue 3A.1 induced [caspase 3] activity and *inhibited* , CDK6 , and COX-2 protein expression . Negative_regulation CASP3 CLU 11231633 789613 Surprisingly , the absence of *had* no effect on [caspase-3] activation , and clusterin accumulation and caspase-3 activation did not colocalize to the same cells . Negative_regulation CASP3 EMP1 18000616 1827026 Inhibition of release *causes* accumulation of [caspase 3] and promotes cell detachment , although the extent depends on the kind of `` external stress '' . Negative_regulation CASP3 EPHB2 11854398 913672 Concomitantly , we have also demonstrated that recombinant Mos , MEK , and are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP3 EPHB2 12048219 968718 Ectopic expression of PKCalpha or -zeta did not affect p38 kinase or but *inhibited* the p53 accumulation and [caspase-3] activation that are required for NO-induced apoptosis of chondrocytes . Negative_regulation CASP3 EPHB2 14720214 1197754 Interestingly , inhibition of dramatically increased mitochondrial malfunction , and *enhanced* [caspase] activation , resulting in enhanced neuronal cell death . Negative_regulation CASP3 EPHB2 15964118 1428212 In addition , the malvidin treatment significantly increased the p38 kinase expression and inhibited the ERK activity , and the effects of malvidin on [caspase-3] activation were *blocked* , respectively , by the and p38 inhibitors . Negative_regulation CASP3 EPHB2 17135301 1716729 Moreover , inhibition of phosphorylation *potentiated* serum withdrawal induced [caspase-3] activity . Negative_regulation CASP3 EPHB2 18490749 1916981 inhibition *led* to cytosolic release of mitochondrial proteins and [caspase] activation . Negative_regulation CASP3 EPHB2 19849845 2160377 In addition , we determined that in the estrogen treated rats there was an increase in the levels of ( p < 0.01 ) and Akt ( p < 0.05 ) at the 24 hour time-point , and that 17 beta-estradiol *blocked* the activation of [caspase-3] ( p < 0.01 ) and subsequent cleavage of PARP ( p < 0.05 ) . Negative_regulation CASP3 EPHB2 20347949 2281885 In addition , MWG extract attenuated activation of [caspase-3] and poly ADP-ribose polymerase (PARP) and *inhibited* the phosphorylation of , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation CASP3 EPHB2 20403072 2282193 inhibition at the initial stage of I/R injury may *cause* changes in c-IAP2 gene expression or [c-IAP2/caspase 3] interactions , resulting in long lasting therapeutic effects . Negative_regulation CASP3 EPHB2 21858143 2469164 Facilitation of activation and *inhibition* of [caspase] activation promotes resistance to Glu excitotoxicity in SCN2.2 cells . Negative_regulation CASP3 EPHB2 22334892 2553985 In response to mutant Htt , is activated and directs a protective transcriptional response and *inhibits* [caspase] activation . Negative_regulation CASP3 EPHB2 22560879 2603175 In addition , down-regulation of *resulted* in activation of [caspase 3] and caspase 9 . Negative_regulation CASP3 FAS 10403377 629014 engagement by an agonistic anti-Fas antibody *resulted* in enhanced [caspase 3] and 8 activity and increased mitochondrial permeability . Negative_regulation CASP3 FAS 11739185 886058 Fas signaling can be interrupted at 3 mains levels : clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector [caspase] *inhibition* of downstream caspase-8 . Negative_regulation CASP3 FAS 12011074 962234 In wild-type mice , stimulation *resulted* in normal activation of [caspase-3] , with the generation of the active p19-p12 complex . Negative_regulation CASP3 FAS 12207331 983578 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Negative_regulation CASP3 FAS 15726400 1409633 Gemcitabine treatment , as well as stimulation of , *resulted* in cleavage of effector [caspase 3] as well as its substrate PARP and caspase 9 , followed by DNA fragmentation . Negative_regulation CASP3 FAS 16314469 1487017 Only markedly *diminished* lung tissue tumor necrosis factor-alpha , IL-6 , IL-10 , interferon-gamma , IL-12 , and [caspase-3] activity . Negative_regulation CASP3 FAS 19962232 2232234 In addition , the pretreatment of BrTet or Vrp followed by Dox *induced* activation of [caspase-3] , release of cytochrome c and AIF from mitochondria into cytosol , loss of mitochondrial transmembrane potential ( DeltaPsi ( m ) ) and elevation of Bax/Bcl-2 ratio , with no effect on activation of caspase-8 and the expression of . Negative_regulation CASP3 FAS 9764613 537366 MoAb induced apoptosis of RA synovial cells in vitro , and proinflammatory cytokines tumour necrosis factor-alpha (TNF-alpha) and IL-1beta , but not IL-6 or IL-8 , *inhibited* the anti-Fas induced apoptosis accompanying up-regulation of Bcl-2 protein expression and reduced expression of [CPP32] and ICH-1L . Negative_regulation CASP3 GPR115 14769384 1182443 Caspase-3 was significantly activated by 20 microM Abeta25-35 and 5 microM Abeta1-40 , but effectively *prevented* the Abeta mediated activation of [caspase-3] . Negative_regulation CASP3 GPR132 14769384 1182432 [Caspase-3] was significantly activated by 20 microM Abeta25-35 and 5 microM Abeta1-40 , but effectively *prevented* the Abeta mediated activation of caspase-3 . Negative_regulation CASP3 GPR87 14769384 1182512 [Caspase-3] was significantly activated by 20 microM Abeta25-35 and 5 microM Abeta1-40 , but effectively *prevented* the Abeta mediated activation of caspase-3 . Negative_regulation CASP3 HBEGF 19010935 2022371 [Caspase-3] activation was attenuated in the *presence* of and PD169316 . Negative_regulation CASP3 IL1B 15818317 1393447 In addition , AdvBcl-2 pretreatment led to diminished cytochrome c release into cytosolic extracts and reduced intragraft production and *inhibited* intragraft [caspase-3] and caspase-9 activity . Negative_regulation CASP3 ITGB2 14971566 1182728 and anti-ICAM-1 antibodies significantly *reduced* activated monocyte induced TUNEL positive HRPE cells , by 48 % ( P = .0051 ) and 38 % ( P = .046 ) , respectively , and [caspase-3] activity by 56 % ( P < .0001 ) and 45 % ( P < .0001 ) , respectively . Negative_regulation CASP3 MAP2K6 11518502 851593 *Activation* of [caspase-3] and induction of apoptosis are blocked both by a inhibitor and by emetine treatment which inhibits MEK kinase ( Mos ) synthesis . Negative_regulation CASP3 MAP2K6 11854398 913678 Concomitantly , we have also demonstrated that recombinant Mos , , and ERK are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP3 MAP2K6 15972258 1497944 Inhibition of *potentiated* TNF induced [caspase-3] activity and cell death , and both those events were suppressed by treatment with fostriecin or calyculin A. Immunoprecipitation experiments revealed an association between p38 MAPK , PP2A and MEK , and the results of a phosphatase assay suggested that PP2A is a downstream target of p38 MAPK . Negative_regulation CASP3 MAP2K6 16672322 1583609 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* caspase activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only [caspase] activity . Negative_regulation CASP3 MAP2K6 20403072 2282199 inhibition at the initial stage of I/R injury may *cause* changes in c-IAP2 gene expression or [c-IAP2/caspase 3] interactions , resulting in long lasting therapeutic effects . Negative_regulation CASP3 MMP28 20396553 1358752 The CDCA derivatives demonstrated various apoptosis hallmarks , such as mitochondrial changes ( reduction of , cytochrome c release , and Smac/ DIABLO translocation ) , *activation* of [caspase-3] ( resulting in the degradation of PARP and DFF45 ) , DNA fragmentation and nuclear condensation . Negative_regulation CASP3 MMP7 20396553 1358767 The CDCA derivatives demonstrated various apoptosis hallmarks , such as mitochondrial changes ( reduction of , cytochrome c release , and Smac/ DIABLO translocation ) , *activation* of [caspase-3] ( resulting in the degradation of PARP and DFF45 ) , DNA fragmentation and nuclear condensation . Negative_regulation CASP3 PGC 22266669 2580051 Under the condition of hypoxia concomitant with serum deprivation , the overexpression of in MSCs *resulted* in a higher expression level of hypoxia-inducible factor-1a (Hif-1a) , a greater ratio of B-cell lymphoma leukemia-2 (Bcl-2)/Bcl-2 associated X protein (Bax) , and a lower level of [caspase 3] compared with the controls , followed by an increased survival rate and an elevated expression level of several proangiogenic factors . Negative_regulation CASP3 RCAN1 21216952 2408322 Here we show that overexpression of in primary neurons *activates* caspase-9 and [caspase-3] and subsequently induces neuronal apoptosis . Negative_regulation CASP3 SMN2 15862279 1400872 Depletion of protein by RNA interference in control fibroblasts *increased* [caspase-3] activity , whereas transfection of SMA fibroblasts with wild-type SMN decreased caspase-3 activity . Negative_regulation CASP3 SNCAIP 16495229 1548803 Thus , *reduces* procaspase-3 hydrolysis and thereby [caspase-3] activity and decreases poly ( ADP-ribose ) polymerase cleavage , two main indicators of apoptotic cell death . Negative_regulation CASP3 SPHK1 16890416 1607670 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating and *inhibiting* [caspase] activity . Negative_regulation CASP3 SPHK1 19597728 2123715 A inhibitor reduced cell colony formation and *activated* [caspase-3] in both TMZ-sensitive and resistant GBM cells . Negative_regulation CASP3 TGM2 12667098 1075287 A discussion of the effect of antibodies , [caspase] *inhibitors* , chemical inhibitors , heat-shock proteins , suppressor peptides and inhibitors upon aggregation and disease is presented . Negative_regulation CASP3 TGM2 17003418 1618413 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Negative_regulation CASP3 TNF 12202395 983056 CD40 ligation and *prevented* release of cytochrome c and activation of [caspase-3] , which could not be explained by effects on the expression of Bcl-2 , Bcl-x ( L ) or Bax . Negative_regulation CASP3 TNF 14505549 1144907 Hepatocyte apoptosis and liver injury and the expression of [caspase-3] could be *blocked* by antagonizing . Negative_regulation CASP3 TNF 14699068 1211562 Additionally , the actin filament stabilizer phallacidin potently blocked the nuclear translocation of nuclear factor-kappaB and its binding activity , resulting in abrogation of the *induced* inhibition of [caspase-3] . Negative_regulation CASP3 TNF 17274948 1697422 Stimulation of the cells with IL6RIL6 plus *resulted* in both the activation of [caspase-3] and the reduction of bcl-2 expression . Negative_regulation CASP3 TNF 18496137 1944934 Compared with Control , Postcon also inhibited translocation of NF-kappa B to nuclei ( 167 % +/- 21 % vs. 142 % +/- 18 % * ) , decreased the level of plasma ( 1,994 +/- 447 vs. 667 +/- 130* pg/mL ) , and *inhibited* [caspase-3] activity ( 0.57 % +/- 0.1 % vs. 0.21 % +/- 0.1 % * ) . Negative_regulation CASP3 TNF 21938476 2532754 With 4-MC pretreatment to hyperglycemic rats the following results were noted : ( i ) Decrease in pancreatic NGF level was blocked , ( ii ) Increase in pancreatic level and the number of TNF-a ( + ) beta cell in the islets were prevented , ( iii ) *Increase* in the number of ß cell synthhesized apoptotic Ras effectors that RASSF1 and NORE1 was blocked , ( iv ) While pancreatic lipid peroxidation level decreased , antioxidant molecule glutathione and antioxidant enzymes glutathione peroxidase , catalase and superoxide dismutase activities increased , ( v ) Pancreatic caspase-3 activity and the number of cleaved [caspase-3] ( + ) ß cells were decreased . Negative_regulation CASP3 TNF 22678778 2620931 Experimental models suggest promising role of newer anti-inflammatory drugs such as antioxidants , inhibitors of , poly-ADP-ribose inhibitors , [caspase] *inhibitors* , brain derived neurotrophic factor etc. ; Negative_regulation CASP3 TNFSF10 17908999 1803425 With the use of locked nucleic acid ( LNA ) -antimiR-21 oligonucleotides , bimodal imaging vectors , and neural precursor cells (NPC) expressing a secretable variant of the cytotoxic agent tumor necrosis factor related apoptosis inducing ligand ( S-TRAIL ) , we show that the combined suppression of miR-21 and *leads* to a synergistic increase in [caspase] activity and significantly decreased cell viability in human glioma cells in vitro . Negative_regulation CASP3 TNFSF10 20951133 2364993 induced loss of cIAP-1 and XIAP *requires* [caspase] activity . Negative_regulation CASP4 CAPN8 11449356 836045 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Negative_regulation CASP4 CAPN8 12199150 982480 Staurosporine induced loss of neuronal particles was blocked by nonselective [caspase] inhibition ( z-VAD-fmk ) and by *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CASP4 CAPN8 20080185 2225885 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known [caspase] inhibitor Z-VAD fmk or by *inhibition* . Negative_regulation CASP4 EPHB2 11854398 913681 Concomitantly , we have also demonstrated that recombinant Mos , MEK , and are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP4 EPHB2 14720214 1197755 Interestingly , inhibition of dramatically increased mitochondrial malfunction , and *enhanced* [caspase] activation , resulting in enhanced neuronal cell death . Negative_regulation CASP4 EPHB2 18490749 1916982 inhibition *led* to cytosolic release of mitochondrial proteins and [caspase] activation . Negative_regulation CASP4 EPHB2 21858143 2469165 Facilitation of activation and *inhibition* of [caspase] activation promotes resistance to Glu excitotoxicity in SCN2.2 cells . Negative_regulation CASP4 EPHB2 22334892 2553987 In response to mutant Htt , is activated and directs a protective transcriptional response and *inhibits* [caspase] activation . Negative_regulation CASP4 FAS 11739185 886059 Fas signaling can be interrupted at 3 mains levels : clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector [caspase] *inhibition* of downstream caspase-8 . Negative_regulation CASP4 FAS 12207331 983579 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Negative_regulation CASP4 MAP2K6 11854398 913687 Concomitantly , we have also demonstrated that recombinant Mos , , and ERK are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP4 MAP2K6 16672322 1583617 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* caspase activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only [caspase] activity . Negative_regulation CASP4 SPHK1 16890416 1607672 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating and *inhibiting* [caspase] activity . Negative_regulation CASP4 TGM2 12667098 1075294 A discussion of the effect of antibodies , [caspase] *inhibitors* , chemical inhibitors , heat-shock proteins , suppressor peptides and inhibitors upon aggregation and disease is presented . Negative_regulation CASP4 TGM2 17003418 1618420 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Negative_regulation CASP4 TNF 22678778 2620932 Experimental models suggest promising role of newer anti-inflammatory drugs such as antioxidants , inhibitors of , poly-ADP-ribose inhibitors , [caspase] *inhibitors* , brain derived neurotrophic factor etc. ; Negative_regulation CASP4 TNFSF10 17908999 1803432 With the use of locked nucleic acid ( LNA ) -antimiR-21 oligonucleotides , bimodal imaging vectors , and neural precursor cells (NPC) expressing a secretable variant of the cytotoxic agent tumor necrosis factor related apoptosis inducing ligand ( S-TRAIL ) , we show that the combined suppression of miR-21 and *leads* to a synergistic increase in [caspase] activity and significantly decreased cell viability in human glioma cells in vitro . Negative_regulation CASP4 TNFSF10 20951133 2364996 induced loss of cIAP-1 and XIAP *requires* [caspase] activity . Negative_regulation CASP5 CAPN8 11449356 836059 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Negative_regulation CASP5 CAPN8 12199150 982494 Staurosporine induced loss of neuronal particles was blocked by nonselective [caspase] inhibition ( z-VAD-fmk ) and by *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CASP5 CAPN8 20080185 2225899 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known [caspase] inhibitor Z-VAD fmk or by *inhibition* . Negative_regulation CASP5 EPHB2 11854398 913690 Concomitantly , we have also demonstrated that recombinant Mos , MEK , and are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP5 EPHB2 14720214 1197756 Interestingly , inhibition of dramatically increased mitochondrial malfunction , and *enhanced* [caspase] activation , resulting in enhanced neuronal cell death . Negative_regulation CASP5 EPHB2 18490749 1916983 inhibition *led* to cytosolic release of mitochondrial proteins and [caspase] activation . Negative_regulation CASP5 EPHB2 21858143 2469166 Facilitation of activation and *inhibition* of [caspase] activation promotes resistance to Glu excitotoxicity in SCN2.2 cells . Negative_regulation CASP5 EPHB2 22334892 2553989 In response to mutant Htt , is activated and directs a protective transcriptional response and *inhibits* [caspase] activation . Negative_regulation CASP5 FAS 11739185 886060 Fas signaling can be interrupted at 3 mains levels : clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector [caspase] *inhibition* of downstream caspase-8 . Negative_regulation CASP5 FAS 12207331 983580 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Negative_regulation CASP5 MAP2K6 11854398 913696 Concomitantly , we have also demonstrated that recombinant Mos , , and ERK are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP5 MAP2K6 16672322 1583625 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* caspase activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only [caspase] activity . Negative_regulation CASP5 SPHK1 16890416 1607674 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating and *inhibiting* [caspase] activity . Negative_regulation CASP5 TGM2 12667098 1075301 A discussion of the effect of antibodies , [caspase] *inhibitors* , chemical inhibitors , heat-shock proteins , suppressor peptides and inhibitors upon aggregation and disease is presented . Negative_regulation CASP5 TGM2 17003418 1618427 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Negative_regulation CASP5 TNF 22678778 2620933 Experimental models suggest promising role of newer anti-inflammatory drugs such as antioxidants , inhibitors of , poly-ADP-ribose inhibitors , [caspase] *inhibitors* , brain derived neurotrophic factor etc. ; Negative_regulation CASP5 TNFSF10 17908999 1803439 With the use of locked nucleic acid ( LNA ) -antimiR-21 oligonucleotides , bimodal imaging vectors , and neural precursor cells (NPC) expressing a secretable variant of the cytotoxic agent tumor necrosis factor related apoptosis inducing ligand ( S-TRAIL ) , we show that the combined suppression of miR-21 and *leads* to a synergistic increase in [caspase] activity and significantly decreased cell viability in human glioma cells in vitro . Negative_regulation CASP5 TNFSF10 20951133 2364999 induced loss of cIAP-1 and XIAP *requires* [caspase] activity . Negative_regulation CASP6 CAPN8 11449356 836073 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Negative_regulation CASP6 CAPN8 12199150 982508 Staurosporine induced loss of neuronal particles was blocked by nonselective [caspase] inhibition ( z-VAD-fmk ) and by *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CASP6 CAPN8 20080185 2225913 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known [caspase] inhibitor Z-VAD fmk or by *inhibition* . Negative_regulation CASP6 EPHB2 11854398 913699 Concomitantly , we have also demonstrated that recombinant Mos , MEK , and are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP6 EPHB2 14720214 1197757 Interestingly , inhibition of dramatically increased mitochondrial malfunction , and *enhanced* [caspase] activation , resulting in enhanced neuronal cell death . Negative_regulation CASP6 EPHB2 18490749 1916984 inhibition *led* to cytosolic release of mitochondrial proteins and [caspase] activation . Negative_regulation CASP6 EPHB2 21858143 2469167 Facilitation of activation and *inhibition* of [caspase] activation promotes resistance to Glu excitotoxicity in SCN2.2 cells . Negative_regulation CASP6 EPHB2 22334892 2553991 In response to mutant Htt , is activated and directs a protective transcriptional response and *inhibits* [caspase] activation . Negative_regulation CASP6 FAS 11739185 886061 Fas signaling can be interrupted at 3 mains levels : clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector [caspase] *inhibition* of downstream caspase-8 . Negative_regulation CASP6 FAS 12207331 983581 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Negative_regulation CASP6 MAP2K6 11854398 913705 Concomitantly , we have also demonstrated that recombinant Mos , , and ERK are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP6 MAP2K6 16672322 1583633 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* caspase activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only [caspase] activity . Negative_regulation CASP6 SPHK1 16890416 1607676 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating and *inhibiting* [caspase] activity . Negative_regulation CASP6 TGM2 12667098 1075308 A discussion of the effect of antibodies , [caspase] *inhibitors* , chemical inhibitors , heat-shock proteins , suppressor peptides and inhibitors upon aggregation and disease is presented . Negative_regulation CASP6 TGM2 17003418 1618434 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Negative_regulation CASP6 TNF 22678778 2620934 Experimental models suggest promising role of newer anti-inflammatory drugs such as antioxidants , inhibitors of , poly-ADP-ribose inhibitors , [caspase] *inhibitors* , brain derived neurotrophic factor etc. ; Negative_regulation CASP6 TNFSF10 17908999 1803446 With the use of locked nucleic acid ( LNA ) -antimiR-21 oligonucleotides , bimodal imaging vectors , and neural precursor cells (NPC) expressing a secretable variant of the cytotoxic agent tumor necrosis factor related apoptosis inducing ligand ( S-TRAIL ) , we show that the combined suppression of miR-21 and *leads* to a synergistic increase in [caspase] activity and significantly decreased cell viability in human glioma cells in vitro . Negative_regulation CASP6 TNFSF10 20951133 2365002 induced loss of cIAP-1 and XIAP *requires* [caspase] activity . Negative_regulation CASP7 CAPN8 11449356 836087 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Negative_regulation CASP7 CAPN8 12199150 982522 Staurosporine induced loss of neuronal particles was blocked by nonselective [caspase] inhibition ( z-VAD-fmk ) and by *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CASP7 CAPN8 20080185 2225927 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known [caspase] inhibitor Z-VAD fmk or by *inhibition* . Negative_regulation CASP7 EPHB2 11854398 913708 Concomitantly , we have also demonstrated that recombinant Mos , MEK , and are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP7 EPHB2 14720214 1197758 Interestingly , inhibition of dramatically increased mitochondrial malfunction , and *enhanced* [caspase] activation , resulting in enhanced neuronal cell death . Negative_regulation CASP7 EPHB2 18490749 1916985 inhibition *led* to cytosolic release of mitochondrial proteins and [caspase] activation . Negative_regulation CASP7 EPHB2 21858143 2469168 Facilitation of activation and *inhibition* of [caspase] activation promotes resistance to Glu excitotoxicity in SCN2.2 cells . Negative_regulation CASP7 EPHB2 22334892 2553993 In response to mutant Htt , is activated and directs a protective transcriptional response and *inhibits* [caspase] activation . Negative_regulation CASP7 FAS 11739185 886062 Fas signaling can be interrupted at 3 mains levels : clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector [caspase] *inhibition* of downstream caspase-8 . Negative_regulation CASP7 FAS 12207331 983582 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Negative_regulation CASP7 MAP2K6 11854398 913714 Concomitantly , we have also demonstrated that recombinant Mos , , and ERK are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP7 MAP2K6 16672322 1583641 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* caspase activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only [caspase] activity . Negative_regulation CASP7 SPHK1 16890416 1607678 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating and *inhibiting* [caspase] activity . Negative_regulation CASP7 TGM2 12667098 1075315 A discussion of the effect of antibodies , [caspase] *inhibitors* , chemical inhibitors , heat-shock proteins , suppressor peptides and inhibitors upon aggregation and disease is presented . Negative_regulation CASP7 TGM2 17003418 1618441 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Negative_regulation CASP7 TNF 22678778 2620935 Experimental models suggest promising role of newer anti-inflammatory drugs such as antioxidants , inhibitors of , poly-ADP-ribose inhibitors , [caspase] *inhibitors* , brain derived neurotrophic factor etc. ; Negative_regulation CASP7 TNFSF10 17908999 1803453 With the use of locked nucleic acid ( LNA ) -antimiR-21 oligonucleotides , bimodal imaging vectors , and neural precursor cells (NPC) expressing a secretable variant of the cytotoxic agent tumor necrosis factor related apoptosis inducing ligand ( S-TRAIL ) , we show that the combined suppression of miR-21 and *leads* to a synergistic increase in [caspase] activity and significantly decreased cell viability in human glioma cells in vitro . Negative_regulation CASP7 TNFSF10 20951133 2365005 induced loss of cIAP-1 and XIAP *requires* [caspase] activity . Negative_regulation CASP8 ANGPT1 23554782 2714258 Specifically , *prevented* DOX induced increases in FasL and Bax levels and cleaved caspase-3 and [caspase-8] levels in H9C2 cells . Negative_regulation CASP8 CAPN8 11449356 836101 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Negative_regulation CASP8 CAPN8 12199150 982536 Staurosporine induced loss of neuronal particles was blocked by nonselective [caspase] inhibition ( z-VAD-fmk ) and by *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CASP8 CAPN8 20080185 2225941 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known [caspase] inhibitor Z-VAD fmk or by *inhibition* . Negative_regulation CASP8 EPHB2 11854398 913717 Concomitantly , we have also demonstrated that recombinant Mos , MEK , and are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP8 EPHB2 12736263 1112945 Despite this , it completely suppresses PICD by sustaining activation and *inhibiting* [caspase 8] activation in phagocytosing neutrophils . Negative_regulation CASP8 EPHB2 14720214 1197759 Interestingly , inhibition of dramatically increased mitochondrial malfunction , and *enhanced* [caspase] activation , resulting in enhanced neuronal cell death . Negative_regulation CASP8 EPHB2 18490749 1916986 inhibition *led* to cytosolic release of mitochondrial proteins and [caspase] activation . Negative_regulation CASP8 EPHB2 20404718 2246104 Since sustained ERK activation can activate caspase-8 in some cell types , we studied the *role* of in Vpr induced [caspase-8] activation . Negative_regulation CASP8 EPHB2 21858143 2469169 Facilitation of activation and *inhibition* of [caspase] activation promotes resistance to Glu excitotoxicity in SCN2.2 cells . Negative_regulation CASP8 EPHB2 22334892 2553995 In response to mutant Htt , is activated and directs a protective transcriptional response and *inhibits* [caspase] activation . Negative_regulation CASP8 FAS 11739185 886063 Fas signaling can be interrupted at 3 mains levels : clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector [caspase] *inhibition* of downstream caspase-8 . Negative_regulation CASP8 FAS 11801595 922390 In the present studies , we found that stimulation of receptors , with either agonistic antibody or CD95 ligand , *resulted* in the activation of [caspase-8] , which in turn processed caspase-3 between its large and small subunits . Negative_regulation CASP8 FAS 12207331 983583 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Negative_regulation CASP8 FAS 14688367 1190736 However , activation *resulted* in [caspase-8] activation and apoptosis only in the presence of cycloheximide ( CHX ) . Negative_regulation CASP8 FAS 15214041 1262838 Similarly , cross linking *resulted* in caspase independent translocation of FADD/MORT1 and [caspase-8] to the lipid rafts , which was prevented by a death domain-defective receptor . Negative_regulation CASP8 FAS 15519734 1328951 In addition , ZB4 , an antagonistic , *inhibited* the activation of [caspase-8] by CoCl ( 2 ) , indicating that Fas receptor was involved in this pathway . Negative_regulation CASP8 FAS 16018969 1435071 In the present study , we investigated the *role* of signaling in [caspase 8] activation induced by fast neutrons irradiation in these cells . Negative_regulation CASP8 FAS 16112422 1448661 These observations argue against a *role* of in gemcitabine induced [caspase-8] activation and reveal that the anti-apoptotic function of DN-FADD differs from caspase-8 inhibition in Colo357 cells . Negative_regulation CASP8 FAS 16246840 1489628 Stimulation of cell surface ( CD95 ) *results* in recruitment of cytoplasmic proteins and activation of [caspase-8] , which in turn activates downstream effector caspases leading to programmed cell death . Negative_regulation CASP8 FAS 18375387 1906954 Lansoprazole also inhibits indomethacin induced Fas mediated mucosal cell death by down regulating or FasL expression and *inhibiting* [caspase-8] activation . Negative_regulation CASP8 FAS 18617900 1972384 In contrast , stimulation of T cells *resulted* in a much more profound activation of [caspase-8] that was exclusively cytosolic . Negative_regulation CASP8 FAS 19107989 2004154 Lack of functional receptors and selective pharmacological *inhibition* of [caspase-8] prevents activation of caspase-3 and provides significant neuroprotection . Negative_regulation CASP8 FAS 22044063 2508293 EA also increased expression of , FasL , and c-Jun N-terminal kinase (JNK) , p38 , and mitogen activated protein kinase (MAPK) and decreased expression of extracellular signal regulated kinase ( ERK ) 1/2-p. Co-treatment with the JNK inhibitor SP600125 *inhibited* EA-induced apoptosis and the activation of [caspase-8] , -9 , and -3 . Negative_regulation CASP8 FAS 22212591 2642696 In addition , cystamine reduced level of and *inhibited* activation of [caspase-8] . Negative_regulation CASP8 FAS 23285096 2711748 However , GTP induced upregulation through activation of c-jun-N-terminal kinase *resulted* in FADD phosphorylation , [caspase-8] activation and truncation of BID , leading to apoptosis in both LNCaPshV and LNCaPshp53 cells . Negative_regulation CASP8 MAP2K6 11854398 913723 Concomitantly , we have also demonstrated that recombinant Mos , , and ERK are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP8 MAP2K6 16672322 1583649 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* caspase activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only [caspase] activity . Negative_regulation CASP8 PLAU 21389187 2416204 In addition , Western blot analysis revealed that downregulation of uPAR and *caused* the activation of [caspase 8] and CAD , which is indicative of apoptosis , and in vivo TUNEL assay confirmed these results . Negative_regulation CASP8 SPHK1 16890416 1607680 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating and *inhibiting* [caspase] activity . Negative_regulation CASP8 TGM2 12667098 1075322 A discussion of the effect of antibodies , [caspase] *inhibitors* , chemical inhibitors , heat-shock proteins , suppressor peptides and inhibitors upon aggregation and disease is presented . Negative_regulation CASP8 TGM2 17003418 1618448 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Negative_regulation CASP8 TNF 17051336 1649461 and IFN-gamma induced apoptosis in HSG cells and *resulted* in the activation of [caspase 8] and the `` death receptor '' pathway . Negative_regulation CASP8 TNF 20951126 2364933 The damnacanthal mediated expression of DR5/TRAIL and *results* in [caspase 8] activation , leading to Bid cleavage . Negative_regulation CASP8 TNF 22678778 2620936 Experimental models suggest promising role of newer anti-inflammatory drugs such as antioxidants , inhibitors of , poly-ADP-ribose inhibitors , [caspase] *inhibitors* , brain derived neurotrophic factor etc. ; Negative_regulation CASP8 TNF 23151904 2723053 CF31 inhibition of activation of AKT also *results* in TNF-a dependent activation of [caspase-8] and apoptosis . Negative_regulation CASP8 TNF 23487422 2766589 We evaluated the role of TNF signaling in pulmonary edema formation in a clinically relevant mouse model of ALI induced by acid aspiration and investigated the effects of p55 receptor deletion , [caspase-8] *inhibition* , and alveolar macrophage depletion on alveolar epithelial function . Negative_regulation CASP8 TNFSF10 11439335 833182 A TNFR1-antagonistic mAb or a decoy receptor *inhibited* the activation of [caspase-8] and the subsequent apoptosis induced by TNFalpha or TRAIL , respectively , in the cells . Negative_regulation CASP8 TNFSF10 11439335 833186 However , neither the TNFR1-antagonistic mAb nor the decoy receptor *inhibited* mAb 225 induced activation of [caspase-8] and apoptosis in DiFi cells . Negative_regulation CASP8 TNFSF10 15475369 1319200 Instead , in the presence of DcR3 , engagement *resulted* in an increased activation of [caspase-8] , an elevated cleavage of Bid , and enhanced release of Smac and cytochrome c from mitochondria to cytosol compared with TRAIL alone . Negative_regulation CASP8 TNFSF10 17908999 1803460 With the use of locked nucleic acid ( LNA ) -antimiR-21 oligonucleotides , bimodal imaging vectors , and neural precursor cells (NPC) expressing a secretable variant of the cytotoxic agent tumor necrosis factor related apoptosis inducing ligand ( S-TRAIL ) , we show that the combined suppression of miR-21 and *leads* to a synergistic increase in [caspase] activity and significantly decreased cell viability in human glioma cells in vitro . Negative_regulation CASP8 TNFSF10 20951126 2364935 The damnacanthal mediated expression of and TNF-R1/TNF-a *results* in [caspase 8] activation , leading to Bid cleavage . Negative_regulation CASP8 TNFSF10 20951133 2365008 induced loss of cIAP-1 and XIAP *requires* [caspase] activity . Negative_regulation CASP8 TNFSF10 23703388 2792452 Here , we show that despite resistance of Bax/Bak double-deficient cells , *resulted* in [caspase-8] activation and complete processing of the caspase-3 proenzymes . Negative_regulation CASP8AP2 ITGB2 10101135 602026 We observe a similar effect in mammalian cells , where expression of can *prevent* [CED-4] and CED-3 from inducing apoptosis . Negative_regulation CASP9 ANGPT1 12824293 1113657 The presence of ( 300 ng/ml ) significantly attenuated endothelial cell apoptosis and *inhibited* [caspase-9] , -7 , and -3 activation . Negative_regulation CASP9 CAPN8 11449356 836115 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Negative_regulation CASP9 CAPN8 12199150 982550 Staurosporine induced loss of neuronal particles was blocked by nonselective [caspase] inhibition ( z-VAD-fmk ) and by *inhibition* ( calpain inhibitor II [ ALLM ] ) . Negative_regulation CASP9 CAPN8 20080185 2225955 In the present research , we show that exposure to MPP ( + ) induce the cell death of neuroblastoma derived dopaminergic B65 cells , which is not reversed by the widely known [caspase] inhibitor Z-VAD fmk or by *inhibition* . Negative_regulation CASP9 EPHB2 11854398 913726 Concomitantly , we have also demonstrated that recombinant Mos , MEK , and are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP9 EPHB2 14720214 1197760 Interestingly , inhibition of dramatically increased mitochondrial malfunction , and *enhanced* [caspase] activation , resulting in enhanced neuronal cell death . Negative_regulation CASP9 EPHB2 18490749 1916987 inhibition *led* to cytosolic release of mitochondrial proteins and [caspase] activation . Negative_regulation CASP9 EPHB2 21858143 2469170 Facilitation of activation and *inhibition* of [caspase] activation promotes resistance to Glu excitotoxicity in SCN2.2 cells . Negative_regulation CASP9 EPHB2 22334892 2553997 In response to mutant Htt , is activated and directs a protective transcriptional response and *inhibits* [caspase] activation . Negative_regulation CASP9 EPHB2 22560879 2603176 In addition , down-regulation of *resulted* in activation of caspase 3 and [caspase 9] . Negative_regulation CASP9 FAS 10647997 662006 By contrast , stimulation alone *resulted* in neither cytochrome c release nor [caspase 9] activation at 3 h , and the increase in the DEVD cleavage activity and apoptosis became evident at later time points . Negative_regulation CASP9 FAS 11739185 886077 Fas signaling can be interrupted at 3 mains levels : clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector [caspase] *inhibition* of downstream caspase-8 . Negative_regulation CASP9 FAS 12207331 983584 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Negative_regulation CASP9 FAS 16527514 1589258 It was found that caspase-3 and -8 inhibitors reduced the accelerative effect of PI 3-K inhibitor on *mediated* apoptosis in OSCC cells , but not [caspase-9] inhibitor . Negative_regulation CASP9 HES2 24604207 2925094 The data revealed that *attenuated* the activation of capase-3 and [caspase-9] . Negative_regulation CASP9 IL1B 15818317 1393448 In addition , AdvBcl-2 pretreatment led to diminished cytochrome c release into cytosolic extracts and reduced intragraft production and *inhibited* intragraft caspase-3 and [caspase-9] activity . Negative_regulation CASP9 IL1B 16845798 1587972 Cultured AF cells were divided into 6 groups and treated with no drug , 10 ng/mL IL-6 , 10 ng/mL IL-1beta , 10 ng/mL IL-1beta and Z-VAD-FMK ( a [caspase-9] *inhibitor* ) , 10 ng/mL and 10 ng/mL IL-6 , 10 ng/mL IL-1beta and 100 ng/mL IL-6 , respectively . Negative_regulation CASP9 MAP2K6 11854398 913732 Concomitantly , we have also demonstrated that recombinant Mos , , and ERK are *sufficient* to block cytochrome c-dependent [caspase] activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CASP9 MAP2K6 16672322 1583657 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* caspase activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only [caspase] activity . Negative_regulation CASP9 RCAN1 21216952 2408323 Here we show that overexpression of in primary neurons *activates* [caspase-9] and caspase-3 and subsequently induces neuronal apoptosis . Negative_regulation CASP9 SPHK1 16890416 1607682 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating and *inhibiting* [caspase] activity . Negative_regulation CASP9 TGM2 12667098 1075329 A discussion of the effect of antibodies , [caspase] *inhibitors* , chemical inhibitors , heat-shock proteins , suppressor peptides and inhibitors upon aggregation and disease is presented . Negative_regulation CASP9 TGM2 17003418 1618455 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Negative_regulation CASP9 TNF 12869386 1149972 SP-600125 , a specific inhibitor of JNK activation , prevented cytochrome c release from mitochondria , JNK activation , DNA fragmentation , and [caspase-9] activation in *response* to . Negative_regulation CASP9 TNF 22678778 2620937 Experimental models suggest promising role of newer anti-inflammatory drugs such as antioxidants , inhibitors of , poly-ADP-ribose inhibitors , [caspase] *inhibitors* , brain derived neurotrophic factor etc. ; Negative_regulation CASP9 TNFSF10 17908999 1803467 With the use of locked nucleic acid ( LNA ) -antimiR-21 oligonucleotides , bimodal imaging vectors , and neural precursor cells (NPC) expressing a secretable variant of the cytotoxic agent tumor necrosis factor related apoptosis inducing ligand ( S-TRAIL ) , we show that the combined suppression of miR-21 and *leads* to a synergistic increase in [caspase] activity and significantly decreased cell viability in human glioma cells in vitro . Negative_regulation CASP9 TNFSF10 20951133 2365011 induced loss of cIAP-1 and XIAP *requires* [caspase] activity . Negative_regulation CASQ2 EDN2 20529095 2271407 *Role* of in the effects of isoprenaline on potassium currents and [calsequestrin 2] expression in the heart . Negative_regulation CASR CABP4 16199532 1483135 Also , osteocalcin , a highly expressed in bone , dose-dependently stimulated GPRC6A activity in the presence of calcium but *inhibited* the calcium dependent activation of [CASR] . Negative_regulation CAST CAPN8 11745202 887576 The treatment of cultured cells with hydrogen peroxide induced both *dependent* cleavage of merlin and reduction of an intrinsic calpain inhibitor [calpastatin] . Negative_regulation CAST CAPN8 16385561 1520124 The restoration of pCREB by protein phosphatase (PP)-1/2A inhibitors or the inhibition of excessive *activation* of by [calpain inhibitor] did not reduce OGD/reoxygenation induced LDH release . Negative_regulation CAST CAPN8 22688056 2633574 In this study , we analyzed the potential therapeutic efficacy of inhibiting the *activation* of by a novel [calpain inhibitor] in aged 3xTgAD mice with well established cognitive impairment , plaques , and tangles . Negative_regulation CAST CAPN8 24200051 2875727 Trichostatin A epigenetically increases [calpastatin] expression and *inhibits* activity and calcium induced SH-SY5Y neuronal cell toxicity . Negative_regulation CAST CAPN8 24262518 2886073 In this study , both and caspase-3-inhibitors *suppressed* postmortem degradation of [calpastatin] . Negative_regulation CAT ARSA 714540 8030 ( 25 mg/100 ml ) did not *impair* RBC G-6-PD , glutathione peroxidase or [catalase] activity , glutathione stability , or hexose monophosphate shunt activity . Negative_regulation CAT FAS 17566139 1848426 All the tested *reduced* [catalase] activity . Negative_regulation CAT FOXO1 17186497 1701656 However , dominant negative *inhibited* [catalase] protein level . Negative_regulation CAT TNF 17879952 1888786 These results indicate that *mediated* downregulation of [catalase] expression and accordingly sufficient H ( 2 ) O ( 2 ) is required for appropriate function of the NF-kappaB dependent survival pathway . Negative_regulation CAV1 EPHB2 19288272 2185411 Pharmacological inhibition of in TAM-R cells *restored* [caveolin-1] and also resulted in the emergence of pools of phosphorylated caveolin-1 . Negative_regulation CAV1 IL1B 20374325 2181244 Treatment with AGFs inhibited *induced* overexpression of [caveolin-1] in human OA chondrocytes . Negative_regulation CAV1 IL1B 20374325 2181245 Our results suggest that AGFs downregulated *induced* chondrocyte ageing and overexpression of [caveolin-1] in human chondrocytes , which is mediated by kinase cascades involving the p42/44 MAP kinase and PI3-K/Akt signalling pathways . Negative_regulation CAV1 TNF 11311151 804928 Interestingly , stimulation of fibroblasts with *resulted* in a partial shift of its p55 receptor to caveolin enriched membrane fractions and the appearance of [caveolin-sensitive] neutral sphingomyelinase activity in the non-caveolar fractions . Negative_regulation CAV1 TNF 11908851 923621 As a comparison , *induced* a decrease of [caveolin-1] in the cells . Negative_regulation CAV1 TNF 18207479 1876670 These data , together with our findings that *suppressed* [caveolin-1] expression in cultured AM , suggest that TNFalpha and downstream signaling mediate activation of NF-kappaB and the regulation of inflammatory genes important in ozone toxicity , and that this process is linked to caveolin-1 . Negative_regulation CAV1 TNF 22752385 2644482 Progressive increases in the expression of myocardial in 28 days and 56 days O ( 3 ) -exposed animals were *followed* by decreases in cardiac [caveolin-1] levels . Negative_regulation CAV1 TNF 23383114 2739511 Rac1 inhibitors significantly abolished this barrier-protective effect induced by down-regulation of [caveolin-1] in *response* to in RPMVECs . Negative_regulation CAV2 TNF 11311151 804929 Interestingly , stimulation of fibroblasts with *resulted* in a partial shift of its p55 receptor to caveolin enriched membrane fractions and the appearance of [caveolin-sensitive] neutral sphingomyelinase activity in the non-caveolar fractions . Negative_regulation CAV3 TNF 11311151 804930 Interestingly , stimulation of fibroblasts with *resulted* in a partial shift of its p55 receptor to caveolin enriched membrane fractions and the appearance of [caveolin-sensitive] neutral sphingomyelinase activity in the non-caveolar fractions . Negative_regulation CCL17 CSK 18557811 1972037 Furthermore , Escherichia coli ( E. coli ) lipopolysaccharide ( TLR4 ligand ) and ( TLR2 ligand ) *inhibited* [CCL17] production by TNF-alpha + IL-4 stimulated HGFs , while CpG DNA ( TLR9 ligand ) enhanced TNF-alpha + IL-4 induced-CCL17 production by HGFs . Negative_regulation CCL17 CXCL10 12446452 1084496 Finally , adenosine augmented the release of the chemokine [CCL17] and *inhibited* production by mDCs . Negative_regulation CCL17 MAPK1 24704449 2935365 Furthermore , we showed that PKC? and p38 *contributed* to the inhibition of TNF-a/IFN-? induced [TARC/CCL17] and MDC/CCL22 expression by blocking I?Ba degradation in HaCaT cells . Negative_regulation CCL17 MAPK10 24704449 2935366 Furthermore , we showed that PKC? and p38 *contributed* to the inhibition of TNF-a/IFN-? induced [TARC/CCL17] and MDC/CCL22 expression by blocking I?Ba degradation in HaCaT cells . Negative_regulation CCL17 MAPK11 24704449 2935367 Furthermore , we showed that PKC? and p38 *contributed* to the inhibition of TNF-a/IFN-? induced [TARC/CCL17] and MDC/CCL22 expression by blocking I?Ba degradation in HaCaT cells . Negative_regulation CCL17 MAPK12 24704449 2935368 Furthermore , we showed that PKC? and p38 *contributed* to the inhibition of TNF-a/IFN-? induced [TARC/CCL17] and MDC/CCL22 expression by blocking I?Ba degradation in HaCaT cells . Negative_regulation CCL17 MAPK13 24704449 2935369 Furthermore , we showed that PKC? and p38 *contributed* to the inhibition of TNF-a/IFN-? induced [TARC/CCL17] and MDC/CCL22 expression by blocking I?Ba degradation in HaCaT cells . Negative_regulation CCL17 MAPK14 24704449 2935370 Furthermore , we showed that PKC? and p38 *contributed* to the inhibition of TNF-a/IFN-? induced [TARC/CCL17] and MDC/CCL22 expression by blocking I?Ba degradation in HaCaT cells . Negative_regulation CCL17 MAPK15 24704449 2935364 Furthermore , we showed that PKC? and p38 *contributed* to the inhibition of TNF-a/IFN-? induced [TARC/CCL17] and MDC/CCL22 expression by blocking I?Ba degradation in HaCaT cells . Negative_regulation CCL17 MAPK3 24704449 2935371 Furthermore , we showed that PKC? and p38 *contributed* to the inhibition of TNF-a/IFN-? induced [TARC/CCL17] and MDC/CCL22 expression by blocking I?Ba degradation in HaCaT cells . Negative_regulation CCL17 MAPK4 24704449 2935372 Furthermore , we showed that PKC? and p38 *contributed* to the inhibition of TNF-a/IFN-? induced [TARC/CCL17] and MDC/CCL22 expression by blocking I?Ba degradation in HaCaT cells . Negative_regulation CCL17 MAPK6 24704449 2935373 Furthermore , we showed that PKC? and p38 *contributed* to the inhibition of TNF-a/IFN-? induced [TARC/CCL17] and MDC/CCL22 expression by blocking I?Ba degradation in HaCaT cells . Negative_regulation CCL17 MAPK7 24704449 2935374 Furthermore , we showed that PKC? and p38 *contributed* to the inhibition of TNF-a/IFN-? induced [TARC/CCL17] and MDC/CCL22 expression by blocking I?Ba degradation in HaCaT cells . Negative_regulation CCL17 MAPK8 24704449 2935375 Furthermore , we showed that PKC? and p38 *contributed* to the inhibition of TNF-a/IFN-? induced [TARC/CCL17] and MDC/CCL22 expression by blocking I?Ba degradation in HaCaT cells . Negative_regulation CCL17 MAPK9 24704449 2935376 Furthermore , we showed that PKC? and p38 *contributed* to the inhibition of TNF-a/IFN-? induced [TARC/CCL17] and MDC/CCL22 expression by blocking I?Ba degradation in HaCaT cells . Negative_regulation CCL17 PAM 18557811 1972038 Furthermore , Escherichia coli ( E. coli ) lipopolysaccharide ( TLR4 ligand ) and ( TLR2 ligand ) *inhibited* [CCL17] production by TNF-alpha + IL-4 stimulated HGFs , while CpG DNA ( TLR9 ligand ) enhanced TNF-alpha + IL-4 induced-CCL17 production by HGFs . Negative_regulation CCL17 STAT6 20393449 2240465 The following study investigates the *role* of the transcriptional activator in IL-4 dependant gene expression of [CCL17] in a Burkitt lymphoma cell line ( Namalwa ) . Negative_regulation CCL17 TGFB1 12413771 1010988 The *induced* down-regulation of [TARC/CCL17] in HaCaT cells suggests that TGF-beta(1) might regulate the TARC related inflammatory processes , which may be important for understanding the pathogenesis of allergic diseases . Negative_regulation CCL2 ANGPT1 17085463 1685069 *suppressed* both renal expression of intercellular adhesion molecule-1 and [monocyte chemoattractant protein-1] and monocyte/macrophage infiltration in diabetic db/db mice . Negative_regulation CCL2 CAPN8 9633934 513190 The effects of norLeu were due to its inhibition of the proteasome rather than calpain , because other inhibitors *had* no effect on [MCP-1] expression . Negative_regulation CCL2 CTGF 16408113 1513387 The present studies investigate the regulatory *role* of in the production of fractalkine , [monocyte chemoattractant protein-1] ( MCP-1 ) , and RANTES ( regulated upon activation , normal T cell expressed and secreted ) in cultured mesangial cells of rats , and the modulatory effects of lipoxin A ( 4 ) ( LXA ( 4 ) ) on actions of CTGF . Negative_regulation CCL2 EDN2 22262076 2520541 Novel interventions , which are reviewed here , include vitamin D receptor activators , RAASi with direct renin inhibitors or aldosterone antagonists , , inflammation suppression with pentoxyfillin , [MCP-1] synthesis *inhibitors* , or with Nrf2 agonists . Negative_regulation CCL2 EFNB1 24098442 2852228 Adenovirus mediated adipose significantly *reduced* the increase in [Mcp-1] mRNA level induced by coculture of 3T3-L1 adipocytes with RAW264.7 cells . Negative_regulation CCL2 EPHB2 12595493 1061584 *inhibited* [MCP-1] and PAI-1 mRNA expression in MC , but not TGF-beta1 . Negative_regulation CCL2 EPHB2 19224633 2044679 MCP-2/CCL8 ( 6-75 ) induced internalization of CCR2 , *inhibited* MCP-1/CCL2 and MCP-2/CCL8 signaling and antagonized the chemotactic activity of several CCR2 ligands ( [MCP-1/CCL2] , MCP-2/CCL8 , MCP-3/CCL7 ) . Negative_regulation CCL2 EPHB2 21290408 2388246 Inhibiting kinase activation *blocked* expression of [MCP-1] . Negative_regulation CCL2 HSD11B2 19776225 2232014 In contrast , overexpression of <11 beta-HSD1> further *augmented* TNF-alpha induced iNOS , IL-6 , and [MCP-1] expression . Negative_regulation CCL2 IL1B 10089132 600001 SB 203580 decreased *induced* MCP-1 mRNA and protein levels , but did not affect [MCP-1] mRNA stability . Negative_regulation CCL2 IL1B 11274229 797574 These data suggested that ( 1 ) constitutive and expression of MCP-1 was differently regulated by AP-1 and NF-kappaB and ( 2 ) t-RA *inhibited* selectively the constitutive expression of [MCP-1] via intervention in the AP-1 pathway . Negative_regulation CCL2 IL1B 12384141 998578 Simultaneously , however , G-CSF pretreatment apparently *enhanced* LPS induced secretion of IL-10 and [monocyte chemoattractant protein-1] , whereas secretions of , IL-6 , and IL-8 were unaffected . Negative_regulation CCL2 IL1B 20712904 2317873 Resveratrol inhibited LPS induced expression and release of TNF-alpha , IL-6 , [MCP-1] , and iNOS/NO in both cell types with more potency in microglia , and *inhibited* LPS induced expression of in microglia but not astrocytes . Negative_regulation CCL2 IL1B 7811465 292534 We determined that stimulation of resident rat PAMs with bacterial lipopolysaccharide (LPS) , murine tumor necrosis factor-alpha , or human *resulted* in the inducible expression of MCP-1 mRNA and the secretion of biologically active [MCP-1] . Negative_regulation CCL2 IL1R2 12372465 996438 Soluble *blocks* [monocyte chemotactic protein-1] secretion by U937 cells in response to peripheral blood serum of women with endometriosis . Negative_regulation CCL2 IL1R2 20590818 2290711 Moreover , we demonstrate that reduction in by RNA interference *increased* IL-1 mediated [CCL2] and CCL5 mRNA and protein expression . Negative_regulation CCL2 MAP2K6 9920834 588009 Consistent with that finding , expression of wild-type or constitutively active significantly *enhanced* the effect of limiting TNF-alpha concentrations on [MCP-1] synthesis . Negative_regulation CCL2 SPHK1 15191888 1295212 We further investigated the *role* of in TNF-alpha induced expression of inflammatory genes , such as [monocyte chemoattractant protein-1] ( MCP-1 ) and VCAM-1 by using small interfering RNA ( siRNA ) specifically for SphK1 . Negative_regulation CCL2 TLR7 17939949 1844441 This study highlights the importance of cytosolic phospholipase A2 (cPLA2) mediated reactive oxygen species ( ROS ) signaling processes in the regulation of [MCP-1] release as a *result* of activation . Negative_regulation CCL2 TLR7 22787112 2645360 Mechanistically , interfered with macrophage proinflammatory responses to TLR2 and TLR4 ligands , *reduced* [monocyte chemoattractant protein-1] production , and prevented expansion of Ly6C ( hi ) inflammatory monocytes and accumulation of inflammatory M1 macrophages into developing atherosclerotic lesions . Negative_regulation CCL2 TNF 10496934 647234 Divergent *roles* of and platelet activating factor in endotoxin induced release of [monocyte chemoattractant protein 1] and macrophage inflammatory protein 1beta in chimpanzees . Negative_regulation CCL2 TNF 10690939 670591 We found that TNF-alpha increased the secretion of [MCP-1] by 55-fold versus the control and troglitazone significantly *inhibited* this induced increase in MCP-1 secretion ( 49.3 % ) . Negative_regulation CCL2 TNF 10716998 676630 We have shown previously that in human monocytes , bacterial lipopolysaccharide , IL-1 , and *induce* a rapid down-regulation of the [monocyte chemotactic protein-1] receptor CCR2 ( CC chemokine receptor-2 ) . Negative_regulation CCL2 TNF 11133741 769343 Consistent with that finding , stimulation with NiCl ( 2 ) or activated IkappaB kinase-beta (IKKbeta) , and transient transfection of dominant negative IKKbeta strongly *inhibited* NiCl ( 2 ) - and TNFalpha induced [MCP-1] expression . Negative_regulation CCL2 TNF 20421523 2256481 The induced proinflammatory response of SMCs is *inhibited* by Nurr1 , as reflected by reduced interleukin-1beta , tumor necrosis factor-alpha , and [monocyte chemoattractant protein-1] expression . Negative_regulation CCL2 TNF 20435921 2288097 TBP and dose-dependently *inhibited* TNFalpha induced secretion of interleukin (IL)-6 , IL-8 , granulocyte macrophage-colony stimulating factor , and [monocyte chemoattractant protein-1] in immortalized human endometriotic cells . Negative_regulation CCL2 TNF 22353423 2586865 In vitro , results based on cultured DRG neurons showed that siRNA mediated inhibition of NOV enhanced IL-1ß- and induced MMP-2 , MMP-9 and [CCL2] expression whereas NOV addition *inhibited* TNF-a induced MMP-9 expression through ß1 integrin engagement . Negative_regulation CCL2 TNF 7811465 292533 We determined that stimulation of resident rat PAMs with bacterial lipopolysaccharide (LPS) , murine , or human interleukin-1 beta *resulted* in the inducible expression of MCP-1 mRNA and the secretion of biologically active [MCP-1] . Negative_regulation CCL2 TNF 8273123 247098 Nor did neutralizing antibodies to *prevent* [MCP-1] production in ABO incompatibility . Negative_regulation CCL20 MAP2K6 19350575 2057623 and JNK inhibitors *suppressed* PRL- or PRL-plus-IL-17 induced [CCL20] production and AP-1 activities . Negative_regulation CCL20 TNF 23178752 2718137 Administering did not prevent splenic T-cell activation , but did *suppress* hepatic [CCL20] expression . Negative_regulation CCL21 TNF 17236235 1696421 *dependent* overexpression of [CCL21] is an underlying cause of progressive lymphoaccumulation in generalized lymphoproliferative disorder . Negative_regulation CCL22 TNF 21852386 2486302 We determined that monocyte derived IL-1ß and are key players as monocyte depletion or neutralization of these cytokines *attenuated* secretion of [CCL22] . Negative_regulation CCL3 EPHB2 14982949 1250916 Constitutively active mitogen activated protein kinase kinase ( MEK ) induced [MIP-1alpha] , and Ras dominant negative ( DN ) *inhibited* IC-induced phosphorylation and MIP-1alpha production . Negative_regulation CCL3 MAP2K6 14982949 1250922 Constitutively active ( MEK ) induced MIP-1alpha , and Ras dominant negative ( DN ) *inhibited* IC-induced ERK phosphorylation and [MIP-1alpha] production . Negative_regulation CCL3 TNF 10877490 708903 Results of these studies show that the anti-viral resistance induced by activation of CD4+ T cells with anti-CD3 + anti-CD28 is primarily conferred by the synthesis of tumor necrosis factor-alpha (TNF-alpha) , and highlight a unique regulatory *role* for in regulating synthesis of [MIP-1alpha] , MIP-1beta , and regulated-on-activation normal T-expressed and secreted cells , which contributes to this state of antiviral resistance to R5-tropic strains of HIV/SIV . Negative_regulation CCL4 IL1B 18789903 1976135 The reduction in induced c-jun expression and subsequent binding of the c-jun/CREB1 complex to AP-1/CRE site mainly *contributed* to the inhibitory action of HE-145 on IL-1beta induced [MIP-1beta] production . Negative_regulation CCL4 TNF 10496934 647235 Divergent *roles* of and platelet activating factor in endotoxin induced release of monocyte chemoattractant protein 1 and [macrophage inflammatory protein 1beta] in chimpanzees . Negative_regulation CCL5 TNF 19353522 2064841 C/EBPbeta knockdown also inhibited the synergistic expression of CXCL1 , inducible nitric oxide synthase , and [CCL5] in *response* to concomitant IFNgamma and . Negative_regulation CCL5 TNF 24523572 2914622 Stimulation of HPFB with IL-1ß and *resulted* in a time- ( up to 96 h ) and dose dependent increase in [CCL5] expression and release . Negative_regulation CCNA1 TNF 18787932 2012243 Induction of apoptosis in U-937 cells by staurosporine or *resulted* in an increase in [cyclin A1] protein expression , which correlated well with cyclin A1 protein modification and the activation of caspase-3 . Negative_regulation CCNA2 ID1 18764931 1969030 Furthermore , using TaqMan Low-density Arrays we identified key pro-angiogenic genes induced by CRP among them were vascular endothelial cell growth factor receptor-2 ( VEGFR2/KDR ) , platelet derived growth factor ( PDGF-BB ) , notch family transcription factors ( Notch1 and Notch3 ) , cysteine-rich angiogenic inducer 61 ( [CYR61/CCN1] ) and *inhibitor* of DNA binding/differentiation-1 ( ) . Negative_regulation CCNA2 IFI27 9789031 542004 The cyclin dependent kinase inhibitor p15(INK4B) blocks association of cyclin dependent kinase (CDK)4/cyclin D and ( kip-1 ) *blocks* activity of [CDK2/cyclin A] and CDK2/cyclin E , complexes that are mandatory for cell-cycle progression . Negative_regulation CCNC CD14 16574244 1582533 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation CCNC LBP 16574244 1582534 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation CCNC MSX1 17130681 1653058 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation CCNC TNF 14550746 1152693 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation CCND1 ABCC6 17510080 1778277 In this study , we identified a novel *role* for in the regulation of [cyclin D1] expression in the absence of AR stimulation in human cancer cells . Negative_regulation CCND1 ACR 12124333 965735 Cotreatment of HepG2 human hepatoma cells with the proteasome inhibitor N-acetyl-Leu-Leu-norleu-al did not prevent the *induced* decrease in [cyclin D1] protein , in contrast to the protective effect of N-acetyl-Leu-Leu-norleu-al on the cyclin D1 protein in cells treated with all-trans-retinoic acid . Negative_regulation CCND1 ACR 12124333 965736 Nevertheless , even in the presence of excess beta-catenin , markedly *inhibited* the transcriptional activity of the [cyclin D1] promoter . Negative_regulation CCND1 ACR 14871993 1208395 Reporter assays indicated that *inhibited* the transcriptional activity of the [cyclin D1] , c-fos , and activator protein promoters . Negative_regulation CCND1 ADIPOQ 17145894 1653962 *mediated* suppression of [cyclin D1] expression and attenuation of cell proliferation was abrogated by the GSK-3beta inhibitor lithium chloride . Negative_regulation CCND1 AGAP2 11136977 758776 Dominant negative *prevents* the NGF enhancement of PI3K and upregulation of [cyclin D1] . Negative_regulation CCND1 AKT1 12124352 965742 Herceptin induced inhibition of phosphatidylinositol-3 kinase and Is *required* for antibody mediated effects on p27 , [cyclin D1] , and antitumor action . Negative_regulation CCND1 AKT1 17130121 1693425 Insulin-like growth factor 1 (IGF-1) treatment or activation *attenuated* the myostatin stimulated [cyclin D1] degradation as well as the associated cell proliferation repression . Negative_regulation CCND1 AKT1 19504174 2157240 Signaling analysis data further demonstrated that myricetin *inhibited* mediated activator protein-1 (AP-1) transactivation , [cyclin D1] expression and cell transformation . Negative_regulation CCND1 AKT1 20529342 2277411 The molecular analysis of tumor samples and in vitro experiments indicated that MTA induces cytostatic rather than pro-apoptotic effects inhibiting the phosphorylation of and S6 ribosomal protein and *inducing* the down-regulation of [cyclin D1] . Negative_regulation CCND1 AKT1 24596136 2955910 Baicalein induced G0/G1-phase arrest in hepatocellular carcinoma cells , *inhibited* , and promoted the degradation of ß-catenin and [cyclin D1] without activation of GSK-3ß . Negative_regulation CCND1 AKT2 12124352 965743 Herceptin induced inhibition of phosphatidylinositol-3 kinase and Is *required* for antibody mediated effects on p27 , [cyclin D1] , and antitumor action . Negative_regulation CCND1 AKT2 17130121 1693426 Insulin-like growth factor 1 (IGF-1) treatment or activation *attenuated* the myostatin stimulated [cyclin D1] degradation as well as the associated cell proliferation repression . Negative_regulation CCND1 AKT2 19504174 2157241 Signaling analysis data further demonstrated that myricetin *inhibited* mediated activator protein-1 (AP-1) transactivation , [cyclin D1] expression and cell transformation . Negative_regulation CCND1 AKT2 20529342 2277412 The molecular analysis of tumor samples and in vitro experiments indicated that MTA induces cytostatic rather than pro-apoptotic effects inhibiting the phosphorylation of and S6 ribosomal protein and *inducing* the down-regulation of [cyclin D1] . Negative_regulation CCND1 AKT2 24596136 2955911 Baicalein induced G0/G1-phase arrest in hepatocellular carcinoma cells , *inhibited* , and promoted the degradation of ß-catenin and [cyclin D1] without activation of GSK-3ß . Negative_regulation CCND1 AKT3 12124352 965744 Herceptin induced inhibition of phosphatidylinositol-3 kinase and Is *required* for antibody mediated effects on p27 , [cyclin D1] , and antitumor action . Negative_regulation CCND1 AKT3 17130121 1693427 Insulin-like growth factor 1 (IGF-1) treatment or activation *attenuated* the myostatin stimulated [cyclin D1] degradation as well as the associated cell proliferation repression . Negative_regulation CCND1 AKT3 19504174 2157242 Signaling analysis data further demonstrated that myricetin *inhibited* mediated activator protein-1 (AP-1) transactivation , [cyclin D1] expression and cell transformation . Negative_regulation CCND1 AKT3 20529342 2277413 The molecular analysis of tumor samples and in vitro experiments indicated that MTA induces cytostatic rather than pro-apoptotic effects inhibiting the phosphorylation of and S6 ribosomal protein and *inducing* the down-regulation of [cyclin D1] . Negative_regulation CCND1 AKT3 24596136 2955912 Baicalein induced G0/G1-phase arrest in hepatocellular carcinoma cells , *inhibited* , and promoted the degradation of ß-catenin and [cyclin D1] without activation of GSK-3ß . Negative_regulation CCND1 ANGPT2 9357777 462000 Consistent with this , *inhibits* [cyclin D1] expression and cyclin D1-associated kinase activity . Negative_regulation CCND1 APC 19148484 2026570 The loss of and GSK3-beta did not *lead* to augmentation of the Wnt target protein [cyclin D1] or the Wnt oncoprotein beta-catenin . Negative_regulation CCND1 APOE 9685360 522046 also *inhibited* PDGF induced [cyclin D1] mRNA expression , suggesting that the apoE effect was mediated by growth arrest at the G0 to G1 phase . Negative_regulation CCND1 ARF1 21478909 2475517 In addition , depletion of or expression of ARF1T ( 31 ) N resulted in the constitutive association of pRB and E2F1 , thereby stabilizing the interaction of E2F1 as well as pRB at endogenous sites of target gene promoters , *preventing* expression of E2F target genes , such as [cyclin D1] , Mcm6 and E2F1 , important for cell-cycle progression . Negative_regulation CCND1 ARNTL 20576619 2309054 However , deficiency *increased* the protein levels of cdc2 , cyclin B1 , [cyclin D1] and cyclin E . Wee1 and cyclin A expression was minimally altered . Negative_regulation CCND1 ARSA 10753205 681729 Overexpression of [cyclin D1] was *induced* by BBN but not and the degree of overexpression was higher in the order simple hyperplasia , papillary or nodular hyperplasia , papilloma and carcinoma . Negative_regulation CCND1 ARSA 14566053 1158694 *reduced* the expression of [cyclin D1] , a downstream target gene that plays an important role in colon carcinogenesis . Negative_regulation CCND1 ARSA 19576865 2142562 *reduced* the expression of Wnt/beta-catenin downstream target gene [cyclin D1] , and total cellular beta-catenin levels . Negative_regulation CCND1 ASD1 11676861 873552 Western blotting demonstrated that while EGF-stimulation led to cyclin D1 over-expression , *inhibited* [cyclin D1] protein expression . Negative_regulation CCND1 ATF1 15205322 1261176 Repression of [cyclin D1] by p16(INK4a) occurred independently of the p16(INK4a)-cdk4 binding function and *required* a cAMP-response binding site . Negative_regulation CCND1 ATF2 10066798 593804 Dominant negative mutants of CREB and but not c-Jun *inhibited* pp60 ( v-src ) induction of [cyclin D1] . Negative_regulation CCND1 ATF2 11850817 913090 However , transcriptional up-regulation of [cyclin D1] by HGF/SF was partially inhibited by the p38 kinase-specific inhibitor , and cyclin D1 protein induction was partially *blocked* by a dominant negative mutant . Negative_regulation CCND1 ATF2 15205322 1261177 Repression of [cyclin D1] by p16(INK4a) occurred independently of the p16(INK4a)-cdk4 binding function and *required* a cAMP-response binding site . Negative_regulation CCND1 ATF2 9990041 597247 Overexpression of in chondrocytes *enhanced* activity of the [cyclin D1] promoter 3 . Negative_regulation CCND1 ATF3 11375399 834920 Northern blot analysis and co-transfection experiments demonstrate that overexpression of enhances cyclin D1 mRNA expression and *activates* the [cyclin D1] promoter 2.5-fold when activating protein-1 (AP-1) and cyclic AMP response element ( CRE ) sites within the promoter are intact . Negative_regulation CCND1 ATF3 15205322 1261178 Repression of [cyclin D1] by p16(INK4a) occurred independently of the p16(INK4a)-cdk4 binding function and *required* a cAMP-response binding site . Negative_regulation CCND1 ATF3 16984628 1628226 Our data suggest that transcriptional induction of the gene in maturing chondrocytes *results* in down-regulation of [cyclin D1] and cyclin A expression as well as activation of RUNX2 dependent transcription . Negative_regulation CCND1 ATF3 23591848 2773224 Overexpression of *increased* [CCND1/2] expression in PC3 and DU145 cancer cells . Negative_regulation CCND1 ATF4 15205322 1261179 Repression of [cyclin D1] by p16(INK4a) occurred independently of the p16(INK4a)-cdk4 binding function and *required* a cAMP-response binding site . Negative_regulation CCND1 ATF5 15205322 1261180 Repression of [cyclin D1] by p16(INK4a) occurred independently of the p16(INK4a)-cdk4 binding function and *required* a cAMP-response binding site . Negative_regulation CCND1 ATF6 15205322 1261181 Repression of [cyclin D1] by p16(INK4a) occurred independently of the p16(INK4a)-cdk4 binding function and *required* a cAMP-response binding site . Negative_regulation CCND1 ATF7 15205322 1261182 Repression of [cyclin D1] by p16(INK4a) occurred independently of the p16(INK4a)-cdk4 binding function and *required* a cAMP-response binding site . Negative_regulation CCND1 AXIN1 11739413 886411 *attenuated* the expression of [cyclin D1] , a Wnt target that promotes the growth and differentiation of mammary lobulo-alveoli . Negative_regulation CCND1 AXIN2 11739413 886412 *attenuated* the expression of [cyclin D1] , a Wnt target that promotes the growth and differentiation of mammary lobulo-alveoli . Negative_regulation CCND1 BAD 17670745 1794009 overexpression *inhibited* G ( 1 ) transit and cell growth as well as [cyclin D1] expression . Negative_regulation CCND1 BAD 17670745 1794010 Estrogen stimulation displaced BAD from TRE/CRE elements in MCF7 cells , whereas overexpression *inhibited* estrogen induced [cyclin D1] synthesis and cell proliferation . Negative_regulation CCND1 BAD 17670745 1794011 Inhibition of endogenous in MCF7 cells markedly increased the proliferative fraction and DNA synthesis , activated Cdks , and *increased* [cyclin D1] protein levels . Negative_regulation CCND1 BAD 21040406 2339105 The effects of knockdown of SULF2 on HCC cells were *mediated* by decreased Akt phosphorylation , downregulation of [cyclin D1] and the anti-apoptotic molecule Bcl-2 , and upregulation of the pro-apoptotic molecule . Negative_regulation CCND1 BANP 16166625 1456591 Our studies reveal that *represses* [cyclin D1] gene expression , which can be reversed by small interfering RNA specific to SMAR1 . Negative_regulation CCND1 BANP 17668048 1776916 In a recent report we have shown that *represses* [Cyclin D1] transcription through recruitment of HDAC1 dependent repressor complex at the MAR site of Cyclin D1 promoter . Negative_regulation CCND1 BANP 20006573 2199866 We have earlier shown that can *repress* the transcription of [Cyclin D1] promoter by forming a HDAC1 dependent repressor complex . Negative_regulation CCND1 BAX 18716166 1951003 Feeding WD to Apc ( 1638N/+ ) mice not only enhanced [cyclin D1] expression in colonic epithelium compared with AIN-76A treatment as previously reported but also significantly *increased* the expression of the antiapoptotic protein B-cell lymphoma 2 (Bcl-2) concomitantly with a decrease in the proapoptotic and the number of apoptotic epithelial cells . Negative_regulation CCND1 BAX 19153211 2079216 In vivo , azacitidine ( 0.8 mg/kg i.p. ) reduced tumor proliferation and induced apoptosis in both xenografts upmodulating the expression of p16INKA , , Bak , p21/WAF1 , and p27/KIP1 , and *inhibiting* the activation of Akt activity and the expression of [cyclin D1] , Bcl-2 , and Bcl-XL . Negative_regulation CCND1 BAX 19471891 2085377 NF-kappaB target gene expression of apoptotic cell death proteins ( , caspase-3 , caspase-9 ) was significantly enhanced , but the expression of anti-apoptotic genes and cell proliferation marker genes ( Bcl-2 , inhibitor of apoptosis protein ( IAP-1 ) and X chromosome IAP (XIAP) , Cox-2 , c-Fos , c-Jun and [cyclin D1] ) was significantly *inhibited* by the combined treatment compared to Rg3 or docetaxel alone . Negative_regulation CCND1 BAX 20732338 2368188 Hormone treatment sustained the growth of the lesions *induced* by MNU by increasing expression of Areg , Bcl-2 , [Ccnd-1] and Vegf genes , while decreasing expression of Bad , , Casp 3 , 8 , 9 and p53 genes . Negative_regulation CCND1 BAX 21209944 2359471 In xenografted tumors , resveratrol upregulated the expressions of TRAIL-R1/DR4 , TRAIL-R2/DR5 , and p27 ( /KIP1 ) , and *inhibited* the expression of Bcl-2 and [cyclin D1] . Negative_regulation CCND1 BCL10 21911473 2496822 Collectively , these data reveal a requisite *role* for the SCF ( Fbx4 ) E3 in regulating [cyclin D1] accumulation , consistent with tumor suppressive function in vivo . Negative_regulation CCND1 BCL10 22687624 2633551 Combination treatment resulted in a synergistic growth inhibition , down-regulation of NF-?B DNA binding activity , *inhibition* of [cyclin D1] , ( L ) , p-Akt , Akt , p-mTOR , and p-Bad , up-regulation of Bax , and induction of cellular apoptosis . Negative_regulation CCND1 BCL2 16847683 1606810 The [Cyclin D1] gene translocation was *detected* by fluorescence in situ hybridisation ( FISH ) , whereas c-myc and genes translocation were absent . Negative_regulation CCND1 BCL2 24022053 2841966 treatment induced apoptosis and autophagic cell death , and *inhibited* [cyclin D1] , HIF1a and Src/Fak signaling in tumors . Negative_regulation CCND1 BCL3 16940298 1627468 Moreover , impaired HBx mediated up-regulation by small interfering RNA for BCL-3 *reduced* HBx mediated [cyclin D1] up-regulation . Negative_regulation CCND1 BHLHE40 21506129 2439207 strongly *repressed* the promoter activity of [cyclin D1] . Negative_regulation CCND1 BHLHE40 21506129 2439208 Forced expression of efficiently *repressed* the [cyclin D1] promoter and expression . Negative_regulation CCND1 BMP2 10903423 712913 *inhibited* estradiol induced [cyclin D1-associated] kinase activity . Negative_regulation CCND1 BRCA1 17278098 1725714 We previously showed that in breast cancer cells , overexpression of *induces* [Cyclin D1] overexpression and increases cell proliferation . Negative_regulation CCND1 BTG2 16456675 1554707 *inhibits* the expression of [cyclin D1] , thus resulting in the arrest of cells at G1/S phase by pRB and p53 dependent manner . Negative_regulation CCND1 CASP1 14647418 1210436 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Negative_regulation CCND1 CASP10 14647418 1210437 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Negative_regulation CCND1 CASP12 14647418 1210447 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Negative_regulation CCND1 CASP14 14647418 1210438 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Negative_regulation CCND1 CASP16 14647418 1210448 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Negative_regulation CCND1 CASP2 14647418 1210439 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Negative_regulation CCND1 CASP3 14647418 1210440 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Negative_regulation CCND1 CASP3 24360936 2911202 In addition , analogue 3A.1 induced activity and *inhibited* [cyclin D1] , CDK6 , and COX-2 protein expression . Negative_regulation CCND1 CASP4 14647418 1210441 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Negative_regulation CCND1 CASP5 14647418 1210442 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Negative_regulation CCND1 CASP6 14647418 1210443 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Negative_regulation CCND1 CASP7 14647418 1210444 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Negative_regulation CCND1 CASP8 14647418 1210445 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Negative_regulation CCND1 CASP9 14647418 1210446 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Negative_regulation CCND1 CAT 10419534 632024 Pretreatment with ebselen , , and the flavoprotein inhibitor diphenylene iodonium each *attenuated* PDGF- and Rac1 mediated [cyclin D(1)] promoter activation , while having no effect on the induction of cyclin D(1) by mitogen activated protein kinase/extracellular signal regulated kinase ( ERK ) kinase-1 ( MEK1 ) , the upstream activator of ERKs . Negative_regulation CCND1 CAV1 10747899 707332 Expression of antisense caveolin-1 increased cyclin D1 levels , whereas overexpression *inhibited* expression of the [cyclin D1] gene . Negative_regulation CCND1 CAV1 10747899 707334 [Cyclin D1] promoter activity was selectively *repressed* by , but not by caveolin-3 , and this repression required the caveolin-1 N terminus . Negative_regulation CCND1 CAV3 10747899 707335 [Cyclin D1] promoter activity was selectively *repressed* by caveolin-1 , but not by , and this repression required the caveolin-1 N terminus . Negative_regulation CCND1 CBX8 17371797 1760202 The mediated *inhibition* of [cyclin D1] expression correlates with recruitment of PC3 to the cyclin D1 promoter , which is accompanied by histone deacetylation . Negative_regulation CCND1 CCND3 7876159 298410 Expression of [cyclin D1] was *induced* in myoblasts by bFGF and TGF beta ( albeit with different kinetics for each factor ) , while induction of expression was inhibited by these growth factors . Negative_regulation CCND1 CD44 20590664 2285888 We found that expression significantly inhibited cell proliferation and *down-regulated* EGR-1 expression and EGR-1 targets [cyclin D1] and cyclin D2 . Negative_regulation CCND1 CDC27 20439707 2262652 Silencing of C/EBPdelta , , or the APC/C coactivator Cdh1 ( FZR1 ) in MCF-10A breast epithelial cells *increased* [cyclin D1] protein expression . Negative_regulation CCND1 CDC37 14701845 1218961 Importantly , overexpression of not only *stimulated* [cyclin D1] binding to wild type Cdk4 but also restored its binding to Cdk4 ( G15A ) . Negative_regulation CCND1 CDC6 19106611 2024755 Ectopic overexpression of in quiescent cells *promoted* [cyclin D1] expression , CDK4 activation and G ( 1 ) progression . Negative_regulation CCND1 CDH1 18187454 1856834 E-cadherin mediated cell-cell adhesion also supports [cyclin D1] induction in these cells , and the combined inhibition of both and integrin adhesion is *required* to prevent the expression of cyclin D1 mRNA and protein . Negative_regulation CCND1 CDH1 20439707 2262653 Silencing of C/EBPdelta , Cdc27 , or the APC/C coactivator ( FZR1 ) in MCF-10A breast epithelial cells *increased* [cyclin D1] protein expression . Negative_regulation CCND1 CDK2 10383891 624676 Under these conditions , and CDK4 protein expression remained unchanged compared with proliferating cells , but expression of [cyclin D1] and p27 ( KIP1 ) was *down-regulated* and cyclin E accumulated in the inactive form . Negative_regulation CCND1 CDK2 20816752 2324981 Analysis of G1 cell cycle regulators expression revealed 2M4VP increased expression of CDK inhibitor , p21Waf1/Cip1 and p15 INK4b , decreased expression of [cyclin D1] and cyclin E , and *inhibited* kinase activities of CDK4 and . Negative_regulation CCND1 CDK2 21429724 2523556 HEGU and isoangustone A reduced the levels of CDK2 and CDK4 as well as cyclin A and [cyclin D1] proteins , and also *induced* a decrease in activity . Negative_regulation CCND1 CDK2 9344597 459127 Thus , even though overexpression of [cyclin D1] can *induce* the expression of cyclin E and phosphorylated , premature activation of cyclin E-CDK2 kinase activity in quiescent cells or during progression through G1 appears to be blocked by CDKIs . Negative_regulation CCND1 CDK4 10383891 624677 Under these conditions , CDK2 and protein expression remained unchanged compared with proliferating cells , but expression of [cyclin D1] and p27 ( KIP1 ) was *down-regulated* and cyclin E accumulated in the inactive form . Negative_regulation CCND1 CDK4 14701845 1218959 However , in contrast to wild type Cdk4 , Cdk4 ( G15A ) , and ( G18A ) had greatly *reduced* binding of [cyclin D1] , Cdc37 , and Hsp90 . Negative_regulation CCND1 CDK4 17996899 1903196 [Cyclin D1] expression markedly *increased* from day 3 , with down-regulation of , which re-elevated on day 14 . Negative_regulation CCND1 CDK4 20816752 2324982 Analysis of G1 cell cycle regulators expression revealed 2M4VP increased expression of CDK inhibitor , p21Waf1/Cip1 and p15 INK4b , decreased expression of [cyclin D1] and cyclin E , and *inhibited* kinase activities of and CDK2 . Negative_regulation CCND1 CDK4 9101469 423026 The recently cloned gene p16 ( MST1 ) has been identified as a putative tumor suppressor gene that binds to and CDK6 ( cyclin dependent kinases ) , *preventing* their interaction with [cyclin D1] and thereby preventing cell cycle progression at the G1 stage . Negative_regulation CCND1 CDK4 9710613 526853 We show that p16 and ( N158 ) *inhibit* the kinase activity of cellular [cyclin D1] complexes through different mechanisms . Negative_regulation CCND1 CDK6 9101469 423027 The recently cloned gene p16 ( MST1 ) has been identified as a putative tumor suppressor gene that binds to CDK4 and ( cyclin dependent kinases ) , *preventing* their interaction with [cyclin D1] and thereby preventing cell cycle progression at the G1 stage . Negative_regulation CCND1 CDKN1A 10806303 692116 EGCG induced ( CIP1/WAF1/SDI1 ) , *inhibited* [cyclin D1-associated] pRB kinase activity , and impaired pRB phosphorylation . Negative_regulation CCND1 CDKN1A 11371120 817651 The aims of this study were to evaluate the regulatory level of cyclin D1 expression and the relationship between the expression of [cyclin D1] and its *inhibitor* , , and to evaluate their impact on the prognosis of early stage cervical cancer . Negative_regulation CCND1 CDKN1A 11917224 925564 The purpose of this study was to evaluate expression of COX-2 in benign and malignant endometrium in the context of other cell cycle and proliferation markers , including Ki-67 , [cyclin D1] , and the cyclin dependent kinase *inhibitor* , . Negative_regulation CCND1 CDKN1A 14647467 1173372 Although overexpression of ( Cip)(I ) *promoted* [cyclin D1] nuclear localization , inhibition of either glycogen synthase kinase 3beta- or CRM1 mediated cyclin D1 nuclear export did not , suggesting that the inhibition of its nuclear import , rather than the acceleration of nuclear export , contributes to cytoplasmic sequestration of cyclin D1 in postmitotic neurons . Negative_regulation CCND1 CDKN1A 15499572 1374758 The levels of expression of G1/S-phase related proteins , such as [cyclin D1] , cyclin dependent kinase (cdk)4 , cdk6 , and proliferating cell nuclear antigen , were reduced and a cdk inhibitor , , was *induced* in rPCT1-CM treated TR-iBRB2 cells . Negative_regulation CCND1 CDKN1A 15557280 1367893 We found that overexpression of wild-type FAK promoted exit from G ( 1 ) in monolayer cultures of glioblastoma cells , *enhanced* the expression of cyclins D1 and E while reducing the expression of p27 ( Kip1 ) and ( Waf1 ) , and enhanced the kinase activity of the [cyclin D1-cyclin] dependent kinase-4 (cdk4) complex . Negative_regulation CCND1 CDKN1A 17443686 1760944 We found that the decrease in [cyclin D1] levels induced by NO was GSH-sensitive implying that the redox regulation of NO-mediated cytostasis was a multifaceted process and that both and p53 independent cyclin D1 pathways were *involved* . Negative_regulation CCND1 CDKN1A 19153211 2079214 In vivo , azacitidine ( 0.8 mg/kg i.p. ) reduced tumor proliferation and induced apoptosis in both xenografts upmodulating the expression of p16INKA , Bax , Bak , , and p27/KIP1 , and *inhibiting* the activation of Akt activity and the expression of [cyclin D1] , Bcl-2 , and Bcl-XL . Negative_regulation CCND1 CDKN1A 20179194 2215784 Further studies revealed that BME treatment enhanced p53 , , and pChk1/2 and *inhibited* cyclin B1 and [cyclin D1] expression , suggesting an additional mechanism involving cell cycle regulation . Negative_regulation CCND1 CDKN1A 20642839 2297553 SFN induced the expression of and p27/KIP1 , and *inhibited* the expression of [cyclin D1] . Negative_regulation CCND1 CDKN1A 21980390 2493071 Resveratrol induced cell cycle arrest by up-regulating the expression of , p27/KIP1 and *inhibiting* the expression of [cyclin D1] . Negative_regulation CCND1 CDKN1A 22191569 2568782 BME treatment enhanced cellular tumor antigen p53 , ( also called p21 ) , and cyclic AMP dependent transcription factor-3 levels and *inhibited* [G1/S-specific cyclin D1] , D2 , and D3 , and mitogen activated protein kinase 8 ( also called Janus kinase ) expression , suggesting an additional mechanism involving cell cycle regulation and cell survival . Negative_regulation CCND1 CDKN1A 23627734 2870419 We also show that increased levels due to treatment with chemotherapeutic agents *result* in increased formation and kinase activity of [cyclin D1/Cdk2] complexes , and that cyclin D1/Cdk2 complexes are able to phosphorylate a number of substrates in addition to Rb . Negative_regulation CCND1 CDKN1A 24606473 2925157 Up-regulation of pRb , , p27 and corresponding *inhibition* of [cyclin D1] and CDK4 were observed . Negative_regulation CCND1 CDKN1A 24939301 2942142 The expression of [cyclin D1] and B1 , p27 and PCNA in VSMCs of paclitaxel treated group was up-regulated , but that of *down-regulated* as compared with VECs . Negative_regulation CCND1 CDKN1A 9858545 581965 In contrast , loss of did not *lead* to deregulated [cyclin D1-dependent] kinase activities , nor did p21 directly regulate cyclin B1/Cdc2 activity . Negative_regulation CCND1 CDKN1B 9111314 425633 As cdk4- and cdk6 associated p15INK4B increased during TGF-beta arrest of sensitive cells , there was a loss of [cyclin D1] , p21Cip1 , and p27Kip1 from these kinase complexes , and cyclin E-cdk2 associated *increased* . Negative_regulation CCND1 CDKN2A 10599415 573776 We previously reported that the [cyclin D1-CDK4/6] *inhibitor* , , is elevated at senescence in HUCs . Negative_regulation CCND1 CDKN2A 15205322 1261174 *repressed* [cyclin D1] expression and transcription . Negative_regulation CCND1 CDKN2A 15205322 1261175 *Repression* of [cyclin D1] by occurred independently of the p16(INK4a)-cdk4 binding function and required a cAMP-response element/activating transcription factor-2 binding site . Negative_regulation CCND1 CDKN2A 15205322 1261198 *repressed* [cyclin D1] through a novel distal cis-element at -1137 , which bound p53 in chromatin-immunoprecipitation assays . Negative_regulation CCND1 CDKN2A 7970707 280047 Activation of the E2F transcription factor by [cyclin D1] is *blocked* by , the product of the putative tumor suppressor gene MTS1 . Negative_regulation CCND1 CDKN2A 9637718 513917 The level of , an endogenous *inhibitor* of the [cyclin D1/cdk4] complex decreased . Negative_regulation CCND1 CDKN2B 9111314 425637 Thus , in TGF-beta arrest , may displace already associated cyclin D1 from cdks and *prevent* new [cyclin D1-cdk] complexes from forming . Negative_regulation CCND1 CDX1 14508520 1145360 Lastly , expression did not alter cyclin D1 mRNA stability but did *reduce* [cyclin D1] promoter activity , suggesting that Cdx1 acts to diminish cyclin D1 gene transcription . Negative_regulation CCND1 CEBPA 11906187 923175 In conclusion , downregulation of [cyclin -D1] , -E , and -A expression , which may be *induced* by impaired activities of and AP-1 , is responsible for the decreased regenerative capacity of cirrhotic liver after partial hepatectomy . Negative_regulation CCND1 CEBPD 20439707 2262654 Silencing of , Cdc27 , or the APC/C coactivator Cdh1 ( FZR1 ) in MCF-10A breast epithelial cells *increased* [cyclin D1] protein expression . Negative_regulation CCND1 CELF1 24502807 2914087 Moreover , depletion of *resulted* in downregulation of cyclin B1 and upregulation of [cyclin D1] . Negative_regulation CCND1 CHUK 18792914 2008956 Soluble and insoluble nickel compounds exert a differential inhibitory effect on cell growth through *dependent* [cyclin D1] down-regulation . Negative_regulation CCND1 CHUK 20080131 2218715 We further show that *dependent* downregulation of [Cyclin D1] expression in the UVB response results from the reduction of ERK1/2 dependent Cyclin D1 transcription coupled with an increase of p38 kinase dependent Cyclin D1 proteolysis . Negative_regulation CCND1 CIB1 19153211 2079213 In vivo , azacitidine ( 0.8 mg/kg i.p. ) reduced tumor proliferation and induced apoptosis in both xenografts upmodulating the expression of p16INKA , Bax , Bak , p21/WAF1 , and , and *inhibiting* the activation of Akt activity and the expression of [cyclin D1] , Bcl-2 , and Bcl-XL . Negative_regulation CCND1 CIB1 20642839 2297552 SFN induced the expression of p21/CIP1 and , and *inhibited* the expression of [cyclin D1] . Negative_regulation CCND1 CISH 14587026 1159650 In both cell lines ATRA and <9-cis> RA *induced* the most profound decreases in [cyclin D1] and cdk2 expression and also mediated the largest growth inhibition . Negative_regulation CCND1 CKS1BP7 12605034 1062761 The highly expressed cyclin dependent kinase 4 (CDK4) is a cell cycle kinase that associates with cyclin D1 for the progression through the G1/S checkpoint , whereas overexpression of *blocks* the inhibition of the [cyclin D1/CDK4] complex by the CDK inhibitor p27/Kip1 . Negative_regulation CCND1 CLDN1 22941467 2697680 In line with this , upon TNF-a stimulus , downregulation of by siRNA knockdown *results* in a significant increase in cleavage of caspase-8 and poly ( ADP-ribose ) polymerase , a decrease of [cyclinD1] expression , and DNA fragmentation . Negative_regulation CCND1 CLMN 22001116 2522169 In contrast , ectopic overexpression of produces an *increase* in the cyclin dependent kinase inhibitor , p21 ( Cip1 ) , a decrease in [cyclin D1] protein and an increase in hypophosphorylated Rb , showing that Clmn participates in G ( 1 ) /S arrest . Negative_regulation CCND1 CNP 17404514 1735990 *inhibits* neurotrophin induced [cyclin D1] expression , and induces the expression of different profiles of inhibitory cell cycle proteins , which are neurotrophin-specific and correlate with the attainment of different maturational cell fates . Negative_regulation CCND1 CRABP1 14713576 1181681 overexpression *resulted* in stimulated [cyclin D1] expression indicating the dependency of this cell cycle control protein on retinoic acid metabolism . Negative_regulation CCND1 CREB1 10066798 593802 Dominant negative mutants of and ATF-2 but not c-Jun *inhibited* pp60 ( v-src ) induction of [cyclin D1] . Negative_regulation CCND1 CREB1 19435810 2084302 In primary keratinocyte cultures , expression induced apoptosis of v-Ras ( Ha ) -infected cells and *suppressed* the expression of cell cycle proteins cyclin B1 and [cyclin D1] . Negative_regulation CCND1 CREB3 10066798 593803 Dominant negative mutants of and ATF-2 but not c-Jun *inhibited* pp60 ( v-src ) induction of [cyclin D1] . Negative_regulation CCND1 CREB3 19435810 2084303 In primary keratinocyte cultures , expression induced apoptosis of v-Ras ( Ha ) -infected cells and *suppressed* the expression of cell cycle proteins cyclin B1 and [cyclin D1] . Negative_regulation CCND1 CREB5 10066798 593801 Dominant negative mutants of and ATF-2 but not c-Jun *inhibited* pp60 ( v-src ) induction of [cyclin D1] . Negative_regulation CCND1 CREB5 19435810 2084301 In primary keratinocyte cultures , expression induced apoptosis of v-Ras ( Ha ) -infected cells and *suppressed* the expression of cell cycle proteins cyclin B1 and [cyclin D1] . Negative_regulation CCND1 CREM 17185632 1717328 Here we show that gastrin induces transcription of cell cycle gene [cyclin D1] and protooncogene c-fos in the neuroendocrine pancreatic cell line AR42J and that this gastrin response is *inhibited* by endogenous . Negative_regulation CCND1 CREM 22488648 2822637 was found to efficiently *repress* the expression of [cyclin D1] in R545 cells due to the binding of ICER to the CRE in the cyclin D1 promoter . Negative_regulation CCND1 CTNNAL1 14993280 1215998 Interestingly , expression *attenuates* the activation of the [cyclin D1] promoter , a target of Wnt pathway signals . Negative_regulation CCND1 CTNNB1 12124333 965737 Nevertheless , even in the *presence* of excess , ACR markedly inhibited the transcriptional activity of the [cyclin D1] promoter . Negative_regulation CCND1 CTNNB1 12707392 1082890 In addition , the overexpression of Wnt-4 and promoted the cell cycle and *increased* the promoter activity and protein expression of [cyclin D1] in LLC-PK1 cells . Negative_regulation CCND1 CTNNB1 14764597 1235123 Since beta-catenin plays a pivotal role in regulating cyclin D1 transcription , we studied whether PPARgamma2 mediated inhibition of [cyclin D1] transcription *involved* . Negative_regulation CCND1 CTNNB1 15111320 1241140 simultaneously *induces* activation of the p53-p21WAF1 pathway and overexpression of [cyclin D1] during squamous differentiation of endometrial carcinoma cells . Negative_regulation CCND1 CTNNB1 15111320 1241143 These findings indicate that in Em Cas , nuclear can simultaneously *induce* activation of the p53-p21WAF1 pathway and overexpression of [cyclin D1] , leading to suppression of cell proliferation or induction of cell senescence . Negative_regulation CCND1 CTNNB1 16328068 1503611 Treatment with wild cherry extract resulted in the suppression of beta-catenin/T cell factor transcription , as assessed by TOP/FOP reporter constructs , suggesting that suppressed signaling by wild cherry extract *leads* to the reduction of [cyclin D1] expression . Negative_regulation CCND1 CTNNB1 17275129 1718272 An associated inhibition of *dependent* Tcf reporter activity , decreased levels of downstream target gene products glutamine synthetase and [cyclin-D1] , and decreased proliferation and survival of hepatoma cells was evident . Negative_regulation CCND1 CTNNB1 17638904 1770891 Treatment of DU145 human prostate cancer cells with 10 and 20 micromol/L apigenin also increased protein levels of E-cadherin by 27 % to 74 % , *inhibited* nuclear translocation of and its retention in the cytoplasm , and decreased c-Myc and [cyclin D1] levels , an effect similar to the exposure of cells to beta-catenin small interfering RNA . Negative_regulation CCND1 CTNNB1 18048388 1861130 Ectopic expression of Dkk3 in lung cancer cells with Dkk3 hypermethylation induced apoptosis and *inhibited* TCF-4 activity as well as nuclear accumulation of and expression of TCF-4 targets c-Myc and [cyclin D1] . Negative_regulation CCND1 CTNNB1 19089909 2031001 It also inhibited the transcriptional activities of , and USF2 , and *inhibited* the expression of endogenous [cyclin D1] and TGFbeta2 . Negative_regulation CCND1 CTNNB1 19091460 2041988 The hexachlorophene modulation of Siah-1 and is independent of p53 and *results* in reduced expression of [cyclin-D1] and c-Myc ( target genes of beta-catenin ) , leading to the growth arrest of B lymphoma cells . Negative_regulation CCND1 CTNND1 16534869 1536561 Furthermore , overexpression of down *regulated* the expression of apoptotic protein survivin and cell cycle regulator [cyclin D1] . Negative_regulation CCND1 CYGB 24737588 2943110 overexpression *inhibited* cell growth , invasion , cell cycle progression and [cyclin D1] expression in SKOV3 cell line and its depletion promoted cell proliferation , invasion , cell cycle transition and cyclin D1 expression . Negative_regulation CCND1 CYLD 18245814 1871588 overexpression also *inhibited* expression of [cyclin D1] and activation of the E2F pathway through deubiquitination of the upstream molecule Bcl-3 and inhibition of its translocation into the nucleus . Negative_regulation CCND1 CYLD 19124656 2025086 As a direct *consequence* of repression , the protooncogene BCL-3 translocates into the nucleus and activates [Cyclin D1] and N-cadherin promoters , resulting in proliferation and invasion of melanoma cells . Negative_regulation CCND1 DAB2 12805222 1101587 Ectopic expression of in NIH-3T3 mouse fibroblasts *attenuates* canonical Wnt/beta-catenin mediated signaling , including accumulation of beta-catenin , activation of beta-catenin/T-cell-specific factor/lymphoid enhancer binding factor 1-dependent reporter constructs , and endogenous [cyclin D1] induction . Negative_regulation CCND1 DACH1 16980615 1616999 *repressed* [cyclin D1] through a novel mechanism via a c-Jun DNA binding partner , requiring the DACH1 alpha-helical DS domain which recruits corepressors to the local chromatin . Negative_regulation CCND1 DCLK2 15863496 1426005 Here we show that a recently identified carbon monoxide releasing molecule , [ Ru ( CO ) <3Cl2> ] 2 ( or CORM-2 ) 1 ) inhibits NAD(P)H oxidase cytochrome b558 activity , 2 ) increases oxidant production by the mitochondria , and 3 ) *inhibits* ASMC proliferation and phosphorylation of the ERK1/2 mitogen activated protein kinase and expression of [cyclin D1] , two critical pathways involved in muscle proliferation . Negative_regulation CCND1 DCN 24342321 2880842 Moreover , we also show that up-regulation of *induced* significant decreases of TGF-ß1 , [cyclin D1] expression , phosphorylation of EGFR , and increases of P53 and P21 expression . Negative_regulation CCND1 DDIT3 19754954 2140425 This was linked to enhanced expression , inhibition of proliferation , induction of apoptosis and luminal clearing in Wt-ErbB2 and to *inhibition* of [cyclin D1] levels and subsequent proliferation in CA-ErbB2 cells . Negative_regulation CCND1 DIRAS3 22528939 2681372 expression *inhibited* [cyclin D1] expression in SK-BR-3 cells and JIMT-1 cells , while it promoted p27 ( Kip1 ) and calpain1 expression in these cells . Negative_regulation CCND1 DKC1 20941532 2364843 Molecular studies showed elevation of Telomerase , viral oncoproteins E6 and E7 , PCNA , p16 , Cyclin D1 in HPV positive cell lines on treatment with estradiol but after treatment with curcumin the level of E7 , PCNA , and [Cyclin D1] was *reduced* but the level of E6 , , and p16 was unaltered . Negative_regulation CCND1 DYRK1B 22711815 2621365 Cirp did not affect binding of to cyclin D1 but *inhibited* phosphorylation of [cyclin D1] by Dyrk1b , resulting in cyclin D1 stabilization . Negative_regulation CCND1 E2F1 10504464 648926 Because we previously reported that the regulation of G1 cyclins is a key factor in the G1/S transition phase in mesangial cells , we showed that overexpression of *induced* protein expression of [cyclin D1] and cyclin E and increased promoter activity . Negative_regulation CCND1 E2F1 12243339 990359 These results suggest that merlin inhibits abnormal cell proliferation which is activated via Ras by repressing Rb phosphorylation , blocking the increase of the [cyclin D1] protein level , and *inhibiting* the activation of AP-1- and dependent transcription in NIH3T3 cells . Negative_regulation CCND1 E2F1 8633069 361789 We found that overexpression *leads* to an inhibition of [cyclin D1-dependent] kinase activity and induces the expression of a p16 related transcript . Negative_regulation CCND1 E2F1 9584162 505024 Inhibition of cyclin D1 kinase activity is associated with mediated *inhibition* of [cyclin D1] promoter activity through E2F and Sp1 . Negative_regulation CCND1 E2F2 9584162 505025 Inhibition of cyclin D1 kinase activity is associated with *mediated* inhibition of [cyclin D1] promoter activity through E2F and Sp1 . Negative_regulation CCND1 E2F3 9584162 505026 Inhibition of cyclin D1 kinase activity is associated with mediated *inhibition* of [cyclin D1] promoter activity through E2F and Sp1 . Negative_regulation CCND1 E2F4 9584162 505027 Inhibition of cyclin D1 kinase activity is associated with *mediated* inhibition of [cyclin D1] promoter activity through E2F and Sp1 . Negative_regulation CCND1 E2F5 9584162 505028 Inhibition of cyclin D1 kinase activity is associated with mediated *inhibition* of [cyclin D1] promoter activity through E2F and Sp1 . Negative_regulation CCND1 E2F6 9584162 505029 Inhibition of cyclin D1 kinase activity is associated with *mediated* inhibition of [cyclin D1] promoter activity through E2F and Sp1 . Negative_regulation CCND1 E2F7 9584162 505022 Inhibition of cyclin D1 kinase activity is associated with *mediated* inhibition of [cyclin D1] promoter activity through E2F and Sp1 . Negative_regulation CCND1 E2F8 9584162 505023 Inhibition of cyclin D1 kinase activity is associated with *mediated* inhibition of [cyclin D1] promoter activity through E2F and Sp1 . Negative_regulation CCND1 ECM1 22678010 2611464 We wondered whether interaction was *involved* in the regulation of [cyclin D1] expression , and the possible signaling pathways in mitogen stimulating podocytes . Negative_regulation CCND1 ECM2 22678010 2611465 We wondered whether interaction was *involved* in the regulation of [cyclin D1] expression , and the possible signaling pathways in mitogen stimulating podocytes . Negative_regulation CCND1 EDAR 19936545 2190469 specifically reduced serum induced Egr-1 expression in VSMCs , further *down-regulated* the expression of [cyclin D1] and TGF-beta1 , and arrested the cells at G0/G1 , inhibiting entry into the S phase . Negative_regulation CCND1 EGF 24126105 2867914 Depletion of Gab1 , using siRNA , decreased the ERK and Akt activation , [cyclin D1] expression , and DNA synthesis in *response* to both and HGF . Negative_regulation CCND1 EGFR 11751523 889946 Treatment with EGCG inhibited phosphorylation of the , signal transducer and activator of transcription3 ( Stat3 ) , and extracellular regulated kinase (ERK) proteins and also *inhibited* basal and transforming growth factor-alpha stimulated c-fos and [cyclin D1] promoter activity . Negative_regulation CCND1 EGFR 18451246 1902944 blockade inhibited these effects and also *caused* increased apoptosis , a p53 independent G ( 0 ) -G ( 1 ) cell cycle arrest , and decreased [cyclin D1] expression . Negative_regulation CCND1 EGFR 21458521 2422634 Over expression of an active in vitamin D sensitive ovarian cancer cells caused resistance to 1,25 ( OH ) ( 2 ) D ( 3 ) -induced growth suppression and *diminished* the hormonal regulation of [cyclin D1] , cyclin E , Skp2 and p27 , a group of cell cycle regulators that mediate 1,25 ( OH ) ( 2 ) D ( 3 ) -induced cell cycle arrest at G1-S checkpoint . Negative_regulation CCND1 EGFR 24486412 2923598 Transfection of HIF-2a siRNA into HCC cells downregulated the expression of VEGF ( vascular endothelial growth factor ) , [cyclin D1] , HIF-2a and TGF-a , and *inhibited* the activation of . Negative_regulation CCND1 EIF4E 15878868 1419283 Exposure of cells to cadmium , as well as the specific silencing of eIF4E gene , also resulted in decreased cellular levels of cyclin D1 , a critical cell cycle and growth regulating gene , suggesting that the observed inhibition of [cyclin D1] gene expression in the cadmium treated cells is most likely *due* to decreased cellular level of . Negative_regulation CCND1 EIF4EBP3 22684010 2633428 In this study , altered <4E-BP3> ( eIF4E binding protein 3 ) expression *resulted* in profoundly affected [cyclin D1] protein levels , partially due to changes in the cytoplasmic cyclin D1 mRNA levels in both U2OS and MCF7 cells , whereas altered 4E-BP1 expression did not affect eIF4E mediated cyclin D1 mRNA export . Negative_regulation CCND1 ENG 22789855 2639789 *inhibits* ERK induced c-Myc and [cyclin D1] expression to impede endothelial cell proliferation . Negative_regulation CCND1 EPHB2 11751523 889947 Treatment with EGCG inhibited phosphorylation of the EGFR , signal transducer and activator of transcription3 ( Stat3 ) , and proteins and also *inhibited* basal and transforming growth factor-alpha stimulated c-fos and [cyclin D1] promoter activity . Negative_regulation CCND1 EPHB2 12791183 1097640 Fourthly , ET-1 increased the phosphorylated level of ERK and the expression of cylin D1 , an inhibitor of *blocked* phosphorylated level of ERK and [cyclin D1] expression . Negative_regulation CCND1 EPHB2 19539699 2103637 Cell-cycle regulators such as cyclin dependent kinase 2 (Cdk2) , [Cyclin D1] and Hes1 *mediated* the effect of on NSCs proliferation and differentiation . Negative_regulation CCND1 EPHB2 24342356 2916999 Further studies showed that SUMOylation at Lys-138 was critical for RhoGDIa down-regulation of [cyclin D1] protein expression and that was a specific downstream *target* of SUMOylated RhoGDIa for its inhibition of C-Jun/AP-1 cascade , cyclin d1 transcription , and cell cycle progression . Negative_regulation CCND1 EPHB2 9407076 470832 Overexpression of dominant negative *resulted* in inhibition of PDGF induced [cyclin D1] expression but had no effect on PDGF induced p27 ( KIP1 ) degradation . Negative_regulation CCND1 ERBB2 20522955 2271263 In this study , CRA dramatically inhibited expression in a dose- and time dependent manner , effectively inhibited cell proliferation , and *induced* G ( 0 ) /G ( 1 ) arrest through the induction of p27 ( kip1 ) and [cyclin D(1)] down-regulation . Negative_regulation CCND1 ESR2 11986316 954183 Strikingly , the presence of completely *inhibits* [cyclin D1] gene activation by estrogen and ERalpha or even by estrogen and the superactive ERalphaK206A . Negative_regulation CCND1 ESR2 15313930 1285811 Moreover , ERalpha and ERbeta had opposite actions on cyclin D1 gene regulation , because *down-regulated* [cyclin D1] gene expression , whereas ERalpha increased cyclin D1 levels . Negative_regulation CCND1 ETS1 15579511 1344883 Furthermore , overexpression of promoted the cell cycle and *increased* the promoter activity and protein expression of [cyclin D1] in LLC-PK1 cells . Negative_regulation CCND1 ETS2 7559524 323576 [Cyclin D1] promoter activity was *stimulated* by overexpression of mitogen activated protein kinase ( p41MAPK ) or through the proximal 22 base pairs . Negative_regulation CCND1 F2RL1 23991105 2836593 Inhibition of miR-34a partially abolished the suppression of [Cyclin D1] *induced* by deficiency . Negative_regulation CCND1 FAM60A 22865885 2677478 Furthermore , depletion of altered the periodic association of HDAC1 with the cyclin D1 promoter , *increased* [cyclin D1] expression at all cell cycle phases , and caused premature S phase entry . Negative_regulation CCND1 FBXO31 20664978 2298233 Ectopic overexpression of *resulted* in down-regulation of [cyclin D1] which leads to the accumulation of cells at the G1 phase of the cell cycle . Negative_regulation CCND1 FBXO4 18598945 1935345 Inhibition of activity *results* in accumulation of nuclear [cyclin D1] and oncogenic transformation . Negative_regulation CCND1 FBXW8 17205132 1663860 A critical *role* for and MAPK in [cyclin D1] degradation and cancer cell proliferation . Negative_regulation CCND1 FBXW8 17205132 1663902 Depletion of *caused* a significant accumulation of [cyclin D1] , as well as sequestration of CDK1 in the cytoplasm . Negative_regulation CCND1 FBXW8 24083669 2863410 Moreover , in HEC108 cells , another endometrial cancer cell line , UA treatment decreased [cyclin D1] , pERK1/2 , and Cullin1 levels in a dose- and time dependent manner and UA markedly *inhibited* . Negative_regulation CCND1 FDFT1 23164604 2735807 Stimulation of MCF-7 with *induced* upregulation of p21 and downregulation of [cyclin D1] , which can cause G1 cell cycle arrest . Negative_regulation CCND1 FHIT 21830375 2468285 The results suggest that increased gene activity can promote apoptosis of cholangiocarcinoma and *reduce* the expression level of [cyclin D1] . Negative_regulation CCND1 FHL2 19018287 1992043 We reported previously that regulates cyclin D1 expression and that immortalized FHL2-null mouse embryo fibroblasts ( MEFs ) display *reduced* levels of [cyclin D1] and low proliferative activity . Negative_regulation CCND1 FLI1 18271016 1911572 In this report , we show that depletion of in Ewing 's cell lines *results* in a senescence phenotype , a marked increase in expression of the G1/S regulatory proteins p27 ( kip1 ) and p57(kip2) , and a significant decrease in [cyclin D1] and CDK2 . Negative_regulation CCND1 FOXE1 22521644 2595752 In MCF-7/TTF-2 stable cell lines , *repressed* the expression of endogenous ERa target genes such as pS2 and [cyclin D1] by interrupting ERa binding to target promoters and also significantly decreased cell proliferation . Negative_regulation CCND1 FOXM1 20332230 2230705 Furthermore , overexpression of in immortalized NHAs *increased* the expression of survivin , [cyclin D1] , and cyclin E , which are important molecules for tumor growth . Negative_regulation CCND1 FUT1 24056538 2846441 We confirmed that directly binds to the C-terminus of Cx43 , whereas Hsc54 , a splice variant of Hsc70 , does not , that Cx43 competes with cyclin D1 for binding to Hsc70 , and that the nuclear accumulation of [cyclin D1] is *reduced* by overexpression of Cx43 in a GJIC independent manner , which is restored by co-overexpression with Hsc70 . Negative_regulation CCND1 GAST 17185632 1717329 Here we show that gastrin induces transcription of cell cycle gene [cyclin D1] and protooncogene c-fos in the neuroendocrine pancreatic cell line AR42J and that this response is *inhibited* by endogenous inducible cAMP early repressor (ICER) . Negative_regulation CCND1 GATA3 20154722 2248566 Overexpression of *induced* [Cyclin D1] promoter activity , which decreased after site directed mutagenesis of the GATA3 binding site in the Cyclin D1 promoter . Negative_regulation CCND1 GATA3 20154722 2248567 Silencing of *resulted* in reduced [Cyclin D1] promoter activity and reduced Cyclin D1 mRNA and protein levels . Negative_regulation CCND1 GEMIN2 17855508 1810516 Direct *repression* of [cyclin D1] by attenuates cell cycle progression in cells undergoing an epithelial mesenchymal transition . Negative_regulation CCND1 GEMIN2 17855508 1810518 Repression of [cyclin D1] was *caused* by direct binding of to three sequence elements in the cyclin D1 gene promoter . Negative_regulation CCND1 GEMIN2 17855508 1810519 By expressing exogenous cyclin D1 in A431/SIP1 cells and using RNA interference , we demonstrated that the *repression* of [cyclin D1] gene by was necessary and sufficient for Rb hypophosphorylation and accumulation of cells in G1 phase . Negative_regulation CCND1 GGNBP2 12522140 1063997 *suppressed* [cyclin D1] expression at both mRNA and protein levels , whereas the overexpression of cyclin D1 overrode DIF-3 induced cell cycle arrest . Negative_regulation CCND1 GLIS2 17289029 1704635 In addition , *represses* the expression of the TCF target gene [cyclin D1] . Negative_regulation CCND1 GLTSCR2 21167305 2390803 Ectopic expression of , both in PTEN positive HeLa cells and in PTEN-deficient U251 cells , effectively *represses* [cyclin D1] expression , arrests the cell cycle at G0/G1 , and promotes cell apoptosis . Negative_regulation CCND1 GP2 22012075 2539733 With regard to proliferation related signals , our finding indicated that SJSZ ( 50 µg/ml ) *diminished* the production of intracellular ROS , activity of phosphorylated ERK , p38 MAPK , NF-?B ( p50 and p65 ) , PCNA , and [cyclin D1/CDK4] in MNNG induced BNL CL.2 cells . Negative_regulation CCND1 GP5 22012075 2539734 With regard to proliferation related signals , our finding indicated that SJSZ ( 50 µg/ml ) *diminished* the production of intracellular ROS , activity of phosphorylated ERK , p38 MAPK , NF-?B ( p50 and p65 ) , PCNA , and [cyclin D1/CDK4] in MNNG induced BNL CL.2 cells . Negative_regulation CCND1 GP6 22012075 2539732 With regard to proliferation related signals , our finding indicated that SJSZ ( 50 µg/ml ) *diminished* the production of intracellular ROS , activity of phosphorylated ERK , p38 MAPK , NF-?B ( p50 and p65 ) , PCNA , and [cyclin D1/CDK4] in MNNG induced BNL CL.2 cells . Negative_regulation CCND1 GP9 22012075 2539735 With regard to proliferation related signals , our finding indicated that SJSZ ( 50 µg/ml ) *diminished* the production of intracellular ROS , activity of phosphorylated ERK , p38 MAPK , NF-?B ( p50 and p65 ) , PCNA , and [cyclin D1/CDK4] in MNNG induced BNL CL.2 cells . Negative_regulation CCND1 GRAP2 21219862 2386424 inhibitor as well as PKC inhibitor *restored* expression of [cyclinD1] and cell growth in AM KO MEF cells . Negative_regulation CCND1 GRAP2 8702807 376064 Furthermore , inhibition of ( MAPK ) activity with the specific inhibitor , SB203580 , *enhanced* [cyclin D1] transcription and protein level . Negative_regulation CCND1 GRK5 22099983 2529545 Also , evidence revealed that the loss of activity *resulted* in decreased [cyclin D1] expression , Rb protein phosphorylation and E2F target gene expression involved in cell cycle control . Negative_regulation CCND1 GSK3B 12235165 1012351 Overexpression of an uninhibitable mutant *resulted* in partial inhibition of FGF-2 mediated [cyclin D1] induction . Negative_regulation CCND1 GSK3B 15753396 1380171 Rapamycin induced down-regulation of [cyclin D1] is *inhibited* by the inhibitors lithium chloride , SB216763 , and SB415286 . Negative_regulation CCND1 GSK3B 16153639 1467406 Depletion of endogenous by RNA interference also *attenuated* the effect of DIF-1 on [cyclin D1] degradation . Negative_regulation CCND1 GSK3B 17437044 1729074 Further , the expression of [cyclin D1] was *down-regulated* by . Negative_regulation CCND1 GSK3B 17895382 1802750 This [cyclin D1] nuclear accumulation *results* from the inhibition of ( GSK3beta ) activity caused by an inhibitory phosphorylation by protein kinase B . Negative_regulation CCND1 GSK3B 17951252 1830778 Inhibitory Ser-9 phosphorylation of ( GSK3beta ) by Akt *prevented* proteasome mediated [cyclin D1] degradation and induced cell cycle progress in LeTx intoxicated THP-1 cells . Negative_regulation CCND1 GSK3B 18084742 1924508 In conclusion , this study demonstrated that cordycepin inhibits the proliferation of B16-BL6 cells by stimulating adenosine A3 receptors followed by the Wnt signaling pathway , including activation and [cyclin D1] *inhibition* . Negative_regulation CCND1 GSK3B 19148484 2026569 The loss of APC and did not *lead* to augmentation of the Wnt target protein [cyclin D1] or the Wnt oncoprotein beta-catenin . Negative_regulation CCND1 GTPBP1 10444391 635968 Cyclin D1 expression on collagen film was inhibited by cytochalasin D and exoenzyme C3 , suggesting a *role* for the , Rho , in regulating [cyclin D1] expression . Negative_regulation CCND1 GTPBP10 10444391 635966 Cyclin D1 expression on collagen film was inhibited by cytochalasin D and exoenzyme C3 , suggesting a *role* for the , Rho , in regulating [cyclin D1] expression . Negative_regulation CCND1 GTPBP2 10444391 635969 Cyclin D1 expression on collagen film was inhibited by cytochalasin D and exoenzyme C3 , suggesting a *role* for the , Rho , in regulating [cyclin D1] expression . Negative_regulation CCND1 GTPBP3 10444391 635963 Cyclin D1 expression on collagen film was inhibited by cytochalasin D and exoenzyme C3 , suggesting a *role* for the , Rho , in regulating [cyclin D1] expression . Negative_regulation CCND1 GTPBP4 10444391 635964 Cyclin D1 expression on collagen film was inhibited by cytochalasin D and exoenzyme C3 , suggesting a *role* for the , Rho , in regulating [cyclin D1] expression . Negative_regulation CCND1 GTPBP6 10444391 635967 Cyclin D1 expression on collagen film was inhibited by cytochalasin D and exoenzyme C3 , suggesting a *role* for the , Rho , in regulating [cyclin D1] expression . Negative_regulation CCND1 GTPBP8 10444391 635965 Cyclin D1 expression on collagen film was inhibited by cytochalasin D and exoenzyme C3 , suggesting a *role* for the , Rho , in regulating [cyclin D1] expression . Negative_regulation CCND1 HBP1 11500377 847045 Here , we show that is a *repressor* of the [cyclin D1] gene and inhibits the Wnt signaling pathway . Negative_regulation CCND1 HBZ 24065533 2857753 In our present study , we observed that expression *suppressed* [cyclin D1] level . Negative_regulation CCND1 HBZ 24065533 2857757 Immunoprecipitation and GST pull-down assays showed the binding of HBZ-bZIP to CRE binding protein (CREB) , which confirmed that the [cyclin D1] promoter activity inhibition via the CRE-site was *mediated* by . Negative_regulation CCND1 HBZ 24065533 2857758 The results suggested that *suppressed* [cyclin D1] transcription through interactions with CREB and along with other viral protein , HBZ may play a causal role for leukemogenesis . Negative_regulation CCND1 HCL1 21541686 2440284 Cinacalcet *suppresses* [Cyclin D1] oncogene derived parathyroid cell proliferation in a murine model for primary hyperparathyroidism . Negative_regulation CCND1 HCL2 21541686 2440285 Cinacalcet *suppresses* [Cyclin D1] oncogene derived parathyroid cell proliferation in a murine model for primary hyperparathyroidism . Negative_regulation CCND1 HCL3 21541686 2440286 Cinacalcet *suppresses* [Cyclin D1] oncogene derived parathyroid cell proliferation in a murine model for primary hyperparathyroidism . Negative_regulation CCND1 HDAC1 14657023 1177210 Removal of the inhibitors from the growth medium of these clones *leads* to downregulation of [cyclin D1] . Negative_regulation CCND1 HDAC1 21465537 2448229 Silencing either or HDAC2 with siRNA also significantly *inhibited* cell proliferation , decreased expression of [Cyclin D1] , and increased expression of p57 . Negative_regulation CCND1 HDAC2 14657023 1177211 Removal of the inhibitors from the growth medium of these clones *leads* to downregulation of [cyclin D1] . Negative_regulation CCND1 HDAC2 21465537 2448230 Silencing either HDAC1 or with siRNA also significantly *inhibited* cell proliferation , decreased expression of [Cyclin D1] , and increased expression of p57 . Negative_regulation CCND1 HDAC2 24965412 2947486 Furthermore , Western blot analyses demonstrated that downregulated expression *inhibited* the expression of [cyclin D1] , cyclin E , and cdk2 proteins but elevated the expression of p21 protein . Negative_regulation CCND1 HEXIM1 18757415 1956556 Increased expression in the mammary gland decreased estrogen-driven ductal morphogenesis and *inhibited* the expression of [cyclin D1] and serine 2 phosphorylated RNA polymerase II ( S2P RNAP II ) . Negative_regulation CCND1 HEXIM1 18757415 1956558 In addition , increased HEXIM1 expression in MCF-7 cells led to a decrease in estrogen induced cyclin D1 expression , whereas down-regulation of expression *led* to an enhancement of estrogen induced [cyclin D1] expression . Negative_regulation CCND1 HGF 24126105 2867915 Depletion of Gab1 , using siRNA , decreased the ERK and Akt activation , [cyclin D1] expression , and DNA synthesis in *response* to both EGF and . Negative_regulation CCND1 HINT1 16014379 1431901 Consistent with these observations , *represses* expression of the endogenous target genes [cyclin D1] and axin2 whereas knockdown of Hint1/PKCI by RNA interference increases their expression . Negative_regulation CCND1 HLA-DRB1 21179458 2358289 Inhibition of FOXO transcription factors by shRNA blocked resveratrol induced upregulation of Bim , TRAIL , , DR5 , p27/KIP1 and apoptosis , and *inhibition* of [cyclin D1] by resveratrol . Negative_regulation CCND1 HLA-DRB1 21209944 2359470 In xenografted tumors , resveratrol upregulated the expressions of TRAIL-R1/DR4 , , Bax and p27 ( /KIP1 ) , and *inhibited* the expression of Bcl-2 and [cyclin D1] . Negative_regulation CCND1 HMGB1 20543468 2279439 significantly *inhibited* the proliferation and [cyclin D1] and PCNA mRNA and protein expression of HMGB1 on HepG2 cells ( P < 0.05 ) . Negative_regulation CCND1 HNRNPU 22276175 2545287 Interestingly , overexpression of *increased* ß-catenin and [cyclin D1] expression , while co-transfection with siRNA targeting ß-catenin abolishes the effect of p120ctn-1A on up-regulation of cyclin D1 , suggesting a role of ß-catenin in mediating p120ctn-1A 's regulatory function on cyclin D1 expression . Negative_regulation CCND1 HPR 15498786 1359592 prevented these changes and *induced* a decrease in expression of iNos , c-myc , [cyclin D1] and Vegf-A genes , that were over expressed in preneoplastic liver and nodules , and a decrease in Bcl-2/Bax , Bcl-2/Bad and Bcl-xL/Bax mRNA ratios with respect to the lesions of control rats . Negative_regulation CCND1 HRAS 12202534 983079 The requirement for and the regulatory *role* of ERK2 in [cyclin D1] production and in cell proliferation suggest that the Ras/Raf/MEK/ERK pathway plays a key role in the control of RPE cell proliferation . Negative_regulation CCND1 HRAS 16496386 1554933 Inhibition of by farnesyl thiosalicylic acid *promoted* proteasomal degradation of [cyclin D1] , with a concomitant decrease in phosphorylated retinoblastoma protein accompanied by downregulation of E2F1 and decreased expression of key E2F1 regulated genes critical for cell-cycle progression . Negative_regulation CCND1 HRAS 9407076 470816 Overexpression of dominant negative forms of Ras or RhoA completely blocked PDGF induced p27 ( KIP1 ) degradation , but only dominant negative *inhibited* [cyclin D1] protein expression . Negative_regulation CCND1 HSP90AA1 20941532 2364844 Molecular studies showed elevation of Telomerase , viral oncoproteins E6 and E7 , PCNA , p16 , Cyclin D1 in HPV positive cell lines on treatment with estradiol but after treatment with curcumin the level of E7 , PCNA , and [Cyclin D1] was *reduced* but the level of E6 , , and p16 was unaltered . Negative_regulation CCND1 ID2 18806828 1993460 Analysis of CRC cell cycle regulatory proteins showed that reducing levels *reduces* [cyclin D1] levels and increased p21 levels . Negative_regulation CCND1 IFI27 11115553 768367 Insufficient effect of ( KIP1 ) to *inhibit* [cyclin D1] in human esophageal cancer in vitro . Negative_regulation CCND1 IFI27 15557280 1367894 We found that overexpression of wild-type FAK promoted exit from G ( 1 ) in monolayer cultures of glioblastoma cells , enhanced the expression of cyclins D1 and E while reducing the expression of ( Kip1 ) and p21 ( Waf1 ) , and *enhanced* the kinase activity of the [cyclin D1-cyclin] dependent kinase-4 (cdk4) complex . Negative_regulation CCND1 IFI27 20642839 2297554 SFN induced the expression of p21/CIP1 and , and *inhibited* the expression of [cyclin D1] . Negative_regulation CCND1 IGF1 17508424 1761891 Thus , we provide a model for cyclin D1 coordinate regulation where FGF-2 stimulation of the MAPK pathway promotes cyclin D1 mRNA expression while activation of the PI3K pathway *inhibits* proteasome degradation of [cyclin D1] and enhances nuclear localization of cyclin D1 . Negative_regulation CCND1 IGH 2426362 61725 We therefore evaluated the *role* of two possible region linked gene products in [BCL1] growth inhibition ; Negative_regulation CCND1 IKBKG 19497850 2115853 peptide significantly *blocked* increases in [cyclin D1] expression , thereby , abrogating hyperplasia of proximal crypts . Negative_regulation CCND1 IL6 10666199 665394 During IL-6 induced macrophage differentiation of M1 cells , *down-regulated* [cyclin D1] expression and induced p19(INK4D) expression , leading to reduction in cdk4 activities . Negative_regulation CCND1 ILK 9153256 431285 overexpression *results* in increased expression of [cyclin D1] , activation of Cdk4 and cyclin E-associated kinases , and hyperphosphorylation of the retinoblastoma protein . Negative_regulation CCND1 INHBA 23169291 2704130 Silencing of expression by siRNA oligonucleotides further confirmed these results and *led* to reduced [cyclin D1/3] expression . Negative_regulation CCND1 INS 11557838 861445 Removing from cultures *resulted* in a reduction in differentially elevated levels of [cyclin D1] . Negative_regulation CCND1 INS 23794242 2849217 *induces* C2C12 cell proliferation and apoptosis through regulation of [cyclin D1] and BAD expression . Negative_regulation CCND1 IRF1 24119616 2867864 We found that overexpression *led* to down-regulation of [cyclin D1/CDK4] and inhibited cell cycle progression in VSMCs under normal glucose conditions . Negative_regulation CCND1 ITGA7 23830872 2829164 The binding *led* to a decreased protein level of tumor necrosis factor a , cytoplasmic translocation of NF-?B , and down-regulation of [cyclin D1] . Negative_regulation CCND1 JAK2 19638583 2118637 The constitutive activation of ErbB2 signaling , which is an initial event in the formation of mammary cancer , was able to override the functional *role* of in regulating the expression of Akt1 and [cyclin D1] . Negative_regulation CCND1 JAK2 22174819 2518342 Mechanistic characterization revealed that NSC-743380 suppressed the phosphorylation of C-terminal domain of RNA polymerase II , induced JNK activation , *inhibited* phosphorylation and suppressed [cyclin D1] expression in sensitive human cancer cells . Negative_regulation CCND1 JARID2 19010785 2016676 A jumonji ( ) protein complex *represses* [cyclin D1] expression by methylation of histone H3-K9 . Negative_regulation CCND1 JARID2 19010785 2016678 Here , we show the mechanisms by which *represses* the transcription of [cyclin D1] . Negative_regulation CCND1 JUN 11906187 923176 In conclusion , downregulation of [cyclin -D1] , -E , and -A expression , which may be *induced* by impaired activities of C/EBP and , is responsible for the decreased regenerative capacity of cirrhotic liver after partial hepatectomy . Negative_regulation CCND1 JUN 12243339 990360 These results suggest that merlin inhibits abnormal cell proliferation which is activated via Ras by repressing Rb phosphorylation , blocking the increase of the [cyclin D1] protein level , and *inhibiting* the activation of and E2F-1 dependent transcription in NIH3T3 cells . Negative_regulation CCND1 JUN 19504174 2157243 Signaling analysis data further demonstrated that myricetin *inhibited* Akt mediated transactivation , [cyclin D1] expression and cell transformation . Negative_regulation CCND1 JUN 20596608 2286034 Pre-treatment of NS3 protein expressing cells with ERK inhibitor , PD98059 , blocked the activation of and NF-kappaB , and *inhibited* [cyclin D1] expression and cell proliferation . Negative_regulation CCND1 JUN 22461029 2612918 Chemical inhibitors of JNK and ERK pathways , dominant negative JNK and , and c-Jun shRNA significantly *inhibited* CCK induced DNA synthesis , CCK induced AP-1 activation , and [cyclin D1] expression . Negative_regulation CCND1 JUN 22727408 2713469 BLU inhibits clonogenic growth of nasopharyngeal carcinoma cells , arrests cell cycle at G1 phase , downregulates JNK and [cyclin D1] promoter activities , and *inhibits* phosphorylation of . Negative_regulation CCND1 KCNK2 21949155 2525398 We developed an MLE-12 cell line deficient in Trek-1 expression using shRNA and found that deficiency *resulted* in increased cell proliferation and upregulation of PCNA but not [Cyclin D1] . Negative_regulation CCND1 KHSRP 17603629 1765187 Upregulation of *led* to downregulation of cyclin A , [cyclin D1] , cyclin E , cyclin dependent kinase 2 , p-Rb , and PCNA , but to upregulation of Rb and p27 expressions . Negative_regulation CCND1 KLF4 20479568 2356974 In addition , forced expression of *inhibited* [cyclin D1] promoter transactivation . Negative_regulation CCND1 KRAS 12202534 983080 The requirement for and the regulatory *role* of ERK2 in [cyclin D1] production and in cell proliferation suggest that the Ras/Raf/MEK/ERK pathway plays a key role in the control of RPE cell proliferation . Negative_regulation CCND1 KRAS 16496386 1554934 Inhibition of by farnesyl thiosalicylic acid *promoted* proteasomal degradation of [cyclin D1] , with a concomitant decrease in phosphorylated retinoblastoma protein accompanied by downregulation of E2F1 and decreased expression of key E2F1 regulated genes critical for cell-cycle progression . Negative_regulation CCND1 KRAS 9407076 470817 Overexpression of dominant negative forms of Ras or RhoA completely blocked PDGF induced p27 ( KIP1 ) degradation , but only dominant negative *inhibited* [cyclin D1] protein expression . Negative_regulation CCND1 LAMB1 24423321 2926980 Furthermore , inhibited epidermal growth factor receptor , AKT , and ERK1/2 phosphorylation and *down-regulated* [cyclin D1] in 8305C and AF cells . Negative_regulation CCND1 LEF1 17885813 1818682 Serum deprived MC3T3-E1 cells normally upregulate Runx2 protein regardless of Lef1 deficiency , although loss of reduces cyclin A and *increases* [cyclin D1] expression upon serum withdrawal . Negative_regulation CCND1 LEP 15319373 1303760 *resulted* in a robust increase in [cyclin D1] expression . Negative_regulation CCND1 LEP 17303663 1726004 The analysis of G1/S-phase cyclins by quantitative ( real-time ) RT-PCR and Western blot points to the *induced* decrease in cyclin A2 and subsequent increase in [cyclin D1] expression that precedes a leptin triggered decrease in the number of prepubertal Leydig cells . Negative_regulation CCND1 LILRB1 24281003 2904556 Furthermore , overexpression or silencing of PA28gamma *reduced* the [cyclinD1] expression at mRNA and protein level in NSCLC cell lines . Negative_regulation CCND1 LILRB1 24570594 2919769 overexpression *reduced* [cyclin D1] expression and increased p21 , caspase-3 , and BAX expression , which subsequently inhibited CRC cell proliferation and induced CRC cell apoptosis . Negative_regulation CCND1 LMO4 19648968 2143373 Loss of subsequently *results* in reduced [Cyclin D1] and Cyclin E . Negative_regulation CCND1 LRRC4 17541939 1841509 expression significantly inhibited the expression of some cytokines and their receptors determined by microarray and Western blot assays , and dramatically *reduced* cytokine induced AP-1 , NF-kB , and [CyclinD1] activation in glioma cells . Negative_regulation CCND1 MAG 16520748 1555081 Furthermore , *suppressed* IL-6 induced promoter activity of [cyclin D1] and monocyte chemotactic protein (MCP)-1 for which STAT3 activation plays a role . Negative_regulation CCND1 MALT1 21911473 2496821 Collectively , these data reveal a requisite *role* for the SCF ( Fbx4 ) E3 in regulating [cyclin D1] accumulation , consistent with tumor suppressive function in vivo . Negative_regulation CCND1 MAP2K1 10504469 648929 In contrast , overexpression of the active form of , the classic MAPK-activator , MKK1 *increased* [cyclin D1] promoter activity and protein level , as well as the percentages of S and G2/M phases . Negative_regulation CCND1 MAP2K1 18702686 1950580 inhibition increased p21 , p27 and cyclin E and JNK inhibition additionally *increased* [cyclin D1] expression . Negative_regulation CCND1 MAP2K1 24342356 2917000 Further studies showed that SUMOylation at Lys-138 was critical for RhoGDIa down-regulation of [cyclin D1] protein expression and that was a specific downstream *target* of SUMOylated RhoGDIa for its inhibition of C-Jun/AP-1 cascade , cyclin d1 transcription , and cell cycle progression . Negative_regulation CCND1 MAP3K3 10207109 606779 The *induced* block of [cyclin D1] expression and of cell cycle progression may be mediated via p38 MAPK , a downstream effector of MEKK3 . Negative_regulation CCND1 MAP3K7 10048449 592531 Western blot analysis demonstrates that the level of [cyclin D1] protein was *regulated* negatively by overexpression of . Negative_regulation CCND1 MAPK1 10504490 649003 In contrast , overexpression of the active form of p42/44 , MKK1 , *increased* [cyclin D1] and A promoter activity and protein levels . Negative_regulation CCND1 MAPK1 12202534 983081 The requirement for Ras and the regulatory *role* of in [cyclin D1] production and in cell proliferation suggest that the Ras/Raf/MEK/ERK pathway plays a key role in the control of RPE cell proliferation . Negative_regulation CCND1 MAPK1 14656993 1201991 Conversely , sustained activation of p38 by the p38 MAPK activating kinases MKK3 and MKK6 or transfection with Sema-3A *inhibited* VEGF induced [cyclin D1] up-regulation and MM cell proliferation . Negative_regulation CCND1 MAPK1 16849370 1600334 Utilizing MCF-7 Tet-Off breast cancer cell lines stably expressing two different nuclear localization defective PTEN mutants , as well as wild-type PTEN and empty vector control cells , we demonstrate that nuclear PTEN down-regulates [cyclin D1] transcription and this event is *mediated* by the down-regulation of specifically by nuclear localized PTEN . Negative_regulation CCND1 MAPK1 17205132 1663862 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Negative_regulation CCND1 MAPK1 20113529 2213134 In contrast , focal adhesion/actin cytoskeleton , and NF B signaling appeared to characterize the target genes and their interacting proteins in [CCND1] *suppressed* PANC1 cells . Negative_regulation CCND1 MAPK1 21219862 2386425 inhibitor as well as PKC inhibitor *restored* expression of [cyclinD1] and cell growth in AM KO MEF cells . Negative_regulation CCND1 MAPK1 7559524 323577 [Cyclin D1] promoter activity was *stimulated* by overexpression of ( p41MAPK ) or c-Ets-2 through the proximal 22 base pairs . Negative_regulation CCND1 MAPK10 10504490 649004 In contrast , overexpression of the active form of p42/44 , MKK1 , *increased* [cyclin D1] and A promoter activity and protein levels . Negative_regulation CCND1 MAPK10 14656993 1201992 Conversely , sustained activation of p38 by the p38 MAPK activating kinases MKK3 and MKK6 or transfection with Sema-3A *inhibited* VEGF induced [cyclin D1] up-regulation and MM cell proliferation . Negative_regulation CCND1 MAPK10 16849370 1600335 Utilizing MCF-7 Tet-Off breast cancer cell lines stably expressing two different nuclear localization defective PTEN mutants , as well as wild-type PTEN and empty vector control cells , we demonstrate that nuclear PTEN down-regulates [cyclin D1] transcription and this event is *mediated* by the down-regulation of specifically by nuclear localized PTEN . Negative_regulation CCND1 MAPK10 17205132 1663863 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Negative_regulation CCND1 MAPK10 20113529 2213135 In contrast , focal adhesion/actin cytoskeleton , and NF B signaling appeared to characterize the target genes and their interacting proteins in [CCND1] *suppressed* PANC1 cells . Negative_regulation CCND1 MAPK10 21219862 2386426 inhibitor as well as PKC inhibitor *restored* expression of [cyclinD1] and cell growth in AM KO MEF cells . Negative_regulation CCND1 MAPK10 7559524 323578 [Cyclin D1] promoter activity was *stimulated* by overexpression of ( p41MAPK ) or c-Ets-2 through the proximal 22 base pairs . Negative_regulation CCND1 MAPK11 10504490 649005 In contrast , overexpression of the active form of p42/44 , MKK1 , *increased* [cyclin D1] and A promoter activity and protein levels . Negative_regulation CCND1 MAPK11 14656993 1201993 Conversely , sustained activation of p38 by the p38 MAPK activating kinases MKK3 and MKK6 or transfection with Sema-3A *inhibited* VEGF induced [cyclin D1] up-regulation and MM cell proliferation . Negative_regulation CCND1 MAPK11 16849370 1600336 Utilizing MCF-7 Tet-Off breast cancer cell lines stably expressing two different nuclear localization defective PTEN mutants , as well as wild-type PTEN and empty vector control cells , we demonstrate that nuclear PTEN down-regulates [cyclin D1] transcription and this event is *mediated* by the down-regulation of specifically by nuclear localized PTEN . Negative_regulation CCND1 MAPK11 17205132 1663864 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Negative_regulation CCND1 MAPK11 20113529 2213136 In contrast , focal adhesion/actin cytoskeleton , and NF B signaling appeared to characterize the target genes and their interacting proteins in [CCND1] *suppressed* PANC1 cells . Negative_regulation CCND1 MAPK11 21219862 2386427 inhibitor as well as PKC inhibitor *restored* expression of [cyclinD1] and cell growth in AM KO MEF cells . Negative_regulation CCND1 MAPK11 7559524 323579 [Cyclin D1] promoter activity was *stimulated* by overexpression of ( p41MAPK ) or c-Ets-2 through the proximal 22 base pairs . Negative_regulation CCND1 MAPK12 10504490 649006 In contrast , overexpression of the active form of p42/44 , MKK1 , *increased* [cyclin D1] and A promoter activity and protein levels . Negative_regulation CCND1 MAPK12 14656993 1201994 Conversely , sustained activation of p38 by the p38 MAPK activating kinases MKK3 and MKK6 or transfection with Sema-3A *inhibited* VEGF induced [cyclin D1] up-regulation and MM cell proliferation . Negative_regulation CCND1 MAPK12 16849370 1600337 Utilizing MCF-7 Tet-Off breast cancer cell lines stably expressing two different nuclear localization defective PTEN mutants , as well as wild-type PTEN and empty vector control cells , we demonstrate that nuclear PTEN down-regulates [cyclin D1] transcription and this event is *mediated* by the down-regulation of specifically by nuclear localized PTEN . Negative_regulation CCND1 MAPK12 17205132 1663865 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Negative_regulation CCND1 MAPK12 20113529 2213137 In contrast , focal adhesion/actin cytoskeleton , and NF B signaling appeared to characterize the target genes and their interacting proteins in [CCND1] *suppressed* PANC1 cells . Negative_regulation CCND1 MAPK12 21219862 2386428 inhibitor as well as PKC inhibitor *restored* expression of [cyclinD1] and cell growth in AM KO MEF cells . Negative_regulation CCND1 MAPK12 7559524 323580 [Cyclin D1] promoter activity was *stimulated* by overexpression of ( p41MAPK ) or c-Ets-2 through the proximal 22 base pairs . Negative_regulation CCND1 MAPK13 10504490 649007 In contrast , overexpression of the active form of p42/44 , MKK1 , *increased* [cyclin D1] and A promoter activity and protein levels . Negative_regulation CCND1 MAPK13 14656993 1201995 Conversely , sustained activation of p38 by the p38 MAPK activating kinases MKK3 and MKK6 or transfection with Sema-3A *inhibited* VEGF induced [cyclin D1] up-regulation and MM cell proliferation . Negative_regulation CCND1 MAPK13 16849370 1600338 Utilizing MCF-7 Tet-Off breast cancer cell lines stably expressing two different nuclear localization defective PTEN mutants , as well as wild-type PTEN and empty vector control cells , we demonstrate that nuclear PTEN down-regulates [cyclin D1] transcription and this event is *mediated* by the down-regulation of specifically by nuclear localized PTEN . Negative_regulation CCND1 MAPK13 17205132 1663866 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Negative_regulation CCND1 MAPK13 20113529 2213138 In contrast , focal adhesion/actin cytoskeleton , and NF B signaling appeared to characterize the target genes and their interacting proteins in [CCND1] *suppressed* PANC1 cells . Negative_regulation CCND1 MAPK13 21219862 2386429 inhibitor as well as PKC inhibitor *restored* expression of [cyclinD1] and cell growth in AM KO MEF cells . Negative_regulation CCND1 MAPK13 7559524 323581 [Cyclin D1] promoter activity was *stimulated* by overexpression of ( p41MAPK ) or c-Ets-2 through the proximal 22 base pairs . Negative_regulation CCND1 MAPK14 10504490 649008 In contrast , overexpression of the active form of p42/44 , MKK1 , *increased* [cyclin D1] and A promoter activity and protein levels . Negative_regulation CCND1 MAPK14 14656993 1201996 Conversely , sustained activation of p38 by the p38 MAPK activating kinases MKK3 and MKK6 or transfection with Sema-3A *inhibited* VEGF induced [cyclin D1] up-regulation and MM cell proliferation . Negative_regulation CCND1 MAPK14 16849370 1600339 Utilizing MCF-7 Tet-Off breast cancer cell lines stably expressing two different nuclear localization defective PTEN mutants , as well as wild-type PTEN and empty vector control cells , we demonstrate that nuclear PTEN down-regulates [cyclin D1] transcription and this event is *mediated* by the down-regulation of specifically by nuclear localized PTEN . Negative_regulation CCND1 MAPK14 17205132 1663867 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Negative_regulation CCND1 MAPK14 20113529 2213139 In contrast , focal adhesion/actin cytoskeleton , and NF B signaling appeared to characterize the target genes and their interacting proteins in [CCND1] *suppressed* PANC1 cells . Negative_regulation CCND1 MAPK14 21219862 2386430 inhibitor as well as PKC inhibitor *restored* expression of [cyclinD1] and cell growth in AM KO MEF cells . Negative_regulation CCND1 MAPK14 7559524 323582 [Cyclin D1] promoter activity was *stimulated* by overexpression of ( p41MAPK ) or c-Ets-2 through the proximal 22 base pairs . Negative_regulation CCND1 MAPK15 10504490 649002 In contrast , overexpression of the active form of p42/44 , MKK1 , *increased* [cyclin D1] and A promoter activity and protein levels . Negative_regulation CCND1 MAPK15 14656993 1201990 Conversely , sustained activation of p38 by the p38 MAPK activating kinases MKK3 and MKK6 or transfection with Sema-3A *inhibited* VEGF induced [cyclin D1] up-regulation and MM cell proliferation . Negative_regulation CCND1 MAPK15 16849370 1600333 Utilizing MCF-7 Tet-Off breast cancer cell lines stably expressing two different nuclear localization defective PTEN mutants , as well as wild-type PTEN and empty vector control cells , we demonstrate that nuclear PTEN down-regulates [cyclin D1] transcription and this event is *mediated* by the down-regulation of specifically by nuclear localized PTEN . Negative_regulation CCND1 MAPK15 17205132 1663861 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Negative_regulation CCND1 MAPK15 20113529 2213133 In contrast , focal adhesion/actin cytoskeleton , and NF B signaling appeared to characterize the target genes and their interacting proteins in [CCND1] *suppressed* PANC1 cells . Negative_regulation CCND1 MAPK15 21219862 2386423 inhibitor as well as PKC inhibitor *restored* expression of [cyclinD1] and cell growth in AM KO MEF cells . Negative_regulation CCND1 MAPK15 7559524 323575 [Cyclin D1] promoter activity was *stimulated* by overexpression of ( p41MAPK ) or c-Ets-2 through the proximal 22 base pairs . Negative_regulation CCND1 MAPK3 10504490 649009 In contrast , overexpression of the active form of p42/44 , MKK1 , *increased* [cyclin D1] and A promoter activity and protein levels . Negative_regulation CCND1 MAPK3 10919709 580579 Inhibition of activity also *led* to decreased cell proliferation and to decreased [cyclin D1] expression . Negative_regulation CCND1 MAPK3 14656993 1201997 Conversely , sustained activation of p38 by the p38 MAPK activating kinases MKK3 and MKK6 or transfection with Sema-3A *inhibited* VEGF induced [cyclin D1] up-regulation and MM cell proliferation . Negative_regulation CCND1 MAPK3 15374964 1297984 In response to 10 % serum , a proliferative stimulus , phosphorylated ERK1/2 initially accumulated in the nucleus , and reduction of nuclear after 2 to 4 hours was *followed* by expression of [cyclin D1] and S-phase entry . Negative_regulation CCND1 MAPK3 16849370 1600340 Utilizing MCF-7 Tet-Off breast cancer cell lines stably expressing two different nuclear localization defective PTEN mutants , as well as wild-type PTEN and empty vector control cells , we demonstrate that nuclear PTEN down-regulates [cyclin D1] transcription and this event is *mediated* by the down-regulation of specifically by nuclear localized PTEN . Negative_regulation CCND1 MAPK3 17205132 1663868 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Negative_regulation CCND1 MAPK3 20113529 2213140 In contrast , focal adhesion/actin cytoskeleton , and NF B signaling appeared to characterize the target genes and their interacting proteins in [CCND1] *suppressed* PANC1 cells . Negative_regulation CCND1 MAPK3 21219862 2386431 inhibitor as well as PKC inhibitor *restored* expression of [cyclinD1] and cell growth in AM KO MEF cells . Negative_regulation CCND1 MAPK3 7559524 323583 [Cyclin D1] promoter activity was *stimulated* by overexpression of ( p41MAPK ) or c-Ets-2 through the proximal 22 base pairs . Negative_regulation CCND1 MAPK4 10504490 649010 In contrast , overexpression of the active form of p42/44 , MKK1 , *increased* [cyclin D1] and A promoter activity and protein levels . Negative_regulation CCND1 MAPK4 14656993 1201998 Conversely , sustained activation of p38 by the p38 MAPK activating kinases MKK3 and MKK6 or transfection with Sema-3A *inhibited* VEGF induced [cyclin D1] up-regulation and MM cell proliferation . Negative_regulation CCND1 MAPK4 16849370 1600341 Utilizing MCF-7 Tet-Off breast cancer cell lines stably expressing two different nuclear localization defective PTEN mutants , as well as wild-type PTEN and empty vector control cells , we demonstrate that nuclear PTEN down-regulates [cyclin D1] transcription and this event is *mediated* by the down-regulation of specifically by nuclear localized PTEN . Negative_regulation CCND1 MAPK4 17205132 1663869 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Negative_regulation CCND1 MAPK4 20113529 2213141 In contrast , focal adhesion/actin cytoskeleton , and NF B signaling appeared to characterize the target genes and their interacting proteins in [CCND1] *suppressed* PANC1 cells . Negative_regulation CCND1 MAPK4 21219862 2386432 inhibitor as well as PKC inhibitor *restored* expression of [cyclinD1] and cell growth in AM KO MEF cells . Negative_regulation CCND1 MAPK4 7559524 323584 [Cyclin D1] promoter activity was *stimulated* by overexpression of ( p41MAPK ) or c-Ets-2 through the proximal 22 base pairs . Negative_regulation CCND1 MAPK6 10504490 649011 In contrast , overexpression of the active form of p42/44 , MKK1 , *increased* [cyclin D1] and A promoter activity and protein levels . Negative_regulation CCND1 MAPK6 14656993 1201999 Conversely , sustained activation of p38 by the p38 MAPK activating kinases MKK3 and MKK6 or transfection with Sema-3A *inhibited* VEGF induced [cyclin D1] up-regulation and MM cell proliferation . Negative_regulation CCND1 MAPK6 16849370 1600342 Utilizing MCF-7 Tet-Off breast cancer cell lines stably expressing two different nuclear localization defective PTEN mutants , as well as wild-type PTEN and empty vector control cells , we demonstrate that nuclear PTEN down-regulates [cyclin D1] transcription and this event is *mediated* by the down-regulation of specifically by nuclear localized PTEN . Negative_regulation CCND1 MAPK6 17205132 1663870 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Negative_regulation CCND1 MAPK6 20113529 2213142 In contrast , focal adhesion/actin cytoskeleton , and NF B signaling appeared to characterize the target genes and their interacting proteins in [CCND1] *suppressed* PANC1 cells . Negative_regulation CCND1 MAPK6 21219862 2386433 inhibitor as well as PKC inhibitor *restored* expression of [cyclinD1] and cell growth in AM KO MEF cells . Negative_regulation CCND1 MAPK6 7559524 323585 [Cyclin D1] promoter activity was *stimulated* by overexpression of ( p41MAPK ) or c-Ets-2 through the proximal 22 base pairs . Negative_regulation CCND1 MAPK7 10504490 649012 In contrast , overexpression of the active form of p42/44 , MKK1 , *increased* [cyclin D1] and A promoter activity and protein levels . Negative_regulation CCND1 MAPK7 14656993 1202000 Conversely , sustained activation of p38 by the p38 MAPK activating kinases MKK3 and MKK6 or transfection with Sema-3A *inhibited* VEGF induced [cyclin D1] up-regulation and MM cell proliferation . Negative_regulation CCND1 MAPK7 16849370 1600343 Utilizing MCF-7 Tet-Off breast cancer cell lines stably expressing two different nuclear localization defective PTEN mutants , as well as wild-type PTEN and empty vector control cells , we demonstrate that nuclear PTEN down-regulates [cyclin D1] transcription and this event is *mediated* by the down-regulation of specifically by nuclear localized PTEN . Negative_regulation CCND1 MAPK7 17205132 1663871 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Negative_regulation CCND1 MAPK7 20113529 2213143 In contrast , focal adhesion/actin cytoskeleton , and NF B signaling appeared to characterize the target genes and their interacting proteins in [CCND1] *suppressed* PANC1 cells . Negative_regulation CCND1 MAPK7 21219862 2386434 inhibitor as well as PKC inhibitor *restored* expression of [cyclinD1] and cell growth in AM KO MEF cells . Negative_regulation CCND1 MAPK7 7559524 323586 [Cyclin D1] promoter activity was *stimulated* by overexpression of ( p41MAPK ) or c-Ets-2 through the proximal 22 base pairs . Negative_regulation CCND1 MAPK8 10504490 649013 In contrast , overexpression of the active form of p42/44 , MKK1 , *increased* [cyclin D1] and A promoter activity and protein levels . Negative_regulation CCND1 MAPK8 14656993 1202001 Conversely , sustained activation of p38 by the p38 MAPK activating kinases MKK3 and MKK6 or transfection with Sema-3A *inhibited* VEGF induced [cyclin D1] up-regulation and MM cell proliferation . Negative_regulation CCND1 MAPK8 16849370 1600344 Utilizing MCF-7 Tet-Off breast cancer cell lines stably expressing two different nuclear localization defective PTEN mutants , as well as wild-type PTEN and empty vector control cells , we demonstrate that nuclear PTEN down-regulates [cyclin D1] transcription and this event is *mediated* by the down-regulation of specifically by nuclear localized PTEN . Negative_regulation CCND1 MAPK8 17205132 1663872 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Negative_regulation CCND1 MAPK8 20113529 2213144 In contrast , focal adhesion/actin cytoskeleton , and NF B signaling appeared to characterize the target genes and their interacting proteins in [CCND1] *suppressed* PANC1 cells . Negative_regulation CCND1 MAPK8 21219862 2386435 inhibitor as well as PKC inhibitor *restored* expression of [cyclinD1] and cell growth in AM KO MEF cells . Negative_regulation CCND1 MAPK8 7559524 323587 [Cyclin D1] promoter activity was *stimulated* by overexpression of ( p41MAPK ) or c-Ets-2 through the proximal 22 base pairs . Negative_regulation CCND1 MAPK9 10504490 649014 In contrast , overexpression of the active form of p42/44 , MKK1 , *increased* [cyclin D1] and A promoter activity and protein levels . Negative_regulation CCND1 MAPK9 14656993 1202002 Conversely , sustained activation of p38 by the p38 MAPK activating kinases MKK3 and MKK6 or transfection with Sema-3A *inhibited* VEGF induced [cyclin D1] up-regulation and MM cell proliferation . Negative_regulation CCND1 MAPK9 16849370 1600345 Utilizing MCF-7 Tet-Off breast cancer cell lines stably expressing two different nuclear localization defective PTEN mutants , as well as wild-type PTEN and empty vector control cells , we demonstrate that nuclear PTEN down-regulates [cyclin D1] transcription and this event is *mediated* by the down-regulation of specifically by nuclear localized PTEN . Negative_regulation CCND1 MAPK9 17205132 1663873 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Negative_regulation CCND1 MAPK9 20113529 2213145 In contrast , focal adhesion/actin cytoskeleton , and NF B signaling appeared to characterize the target genes and their interacting proteins in [CCND1] *suppressed* PANC1 cells . Negative_regulation CCND1 MAPK9 21219862 2386436 inhibitor as well as PKC inhibitor *restored* expression of [cyclinD1] and cell growth in AM KO MEF cells . Negative_regulation CCND1 MAPK9 7559524 323588 [Cyclin D1] promoter activity was *stimulated* by overexpression of ( p41MAPK ) or c-Ets-2 through the proximal 22 base pairs . Negative_regulation CCND1 MAPKAP1 24626091 2934216 Notably , selective inhibition of *triggered* proteasome mediated [cyclin D1] degradation , suggesting that mTORC2 blockade is responsible for GSK3 dependent reduction of cyclin D1 . Negative_regulation CCND1 MAT1A 22318685 2617581 Forced overexpression in HepG2 and HuH7 cells *led* to a rise in the SAM level , decreased cell proliferation , increased apoptosis , down-regulation of [Cyclin D1] , E2F1 , IKK , NF-?B , and antiapoptotic BCL2 and XIAP genes , and up-regulation of BAX and BAK proapoptotic genes . Negative_regulation CCND1 MIR195 22802111 2645779 Using bioinformatics prediction and experimental studies , we showed that could *repress* the expression of Cdc42 , [CCND1] , and FGF1 genes . Negative_regulation CCND1 MKNK1 20499137 2362886 Furthermore , inhibitor *led* to reduced [cyclin D1] expression and caused inhibition of cell proliferation and cell death in human brain malignant lymphoma cell line ( HKBML ) . Negative_regulation CCND1 MLST8 19364503 2065066 Here , we show that inhibition of with its specific inhibitor , rapamycin , suppresses normal thymocyte DNA synthesis by downregulating 4EBP1 , but not S6K , and that 4EBP1 phosphorylation and [cyclin D1] expression are coordinately *increased* in Atm-/- thymocytes . Negative_regulation CCND1 MLST8 24626091 2934217 Notably , selective inhibition of *triggered* proteasome mediated [cyclin D1] degradation , suggesting that mTORC2 blockade is responsible for GSK3 dependent reduction of cyclin D1 . Negative_regulation CCND1 MMP2 19538881 2099063 It seems to be related with down regulating the expression of [cyclin D1] and CDK4 and *inhibiting* the activity of . Negative_regulation CCND1 MNT 19086036 2041959 Switch from to Myc-Max *induces* p53 and [cyclin D1] expression and apoptosis during cholestasis in mouse and human hepatocytes . Negative_regulation CCND1 MSC 18855134 2141660 alone or MSC + tamoxifen significantly *reduced* ERalpha , PR and [cyclin D1] , Ki67 index and microvessel density while increasing apoptosis in tumor tissues . Negative_regulation CCND1 MSX2 18786927 1986160 Overexpression of wild type in mesenchymal cells *stimulated* cell proliferation and [cyclin D1] expression , whereas P148H mutant did not . Negative_regulation CCND1 MTA1 21209952 2359491 *inhibited* the activation and proliferation of isolated myofibroblasts and down-regulated [cyclin D1] gene expression at the transcriptional level . Negative_regulation CCND1 MTA2 21209952 2359492 *inhibited* the activation and proliferation of isolated myofibroblasts and down-regulated [cyclin D1] gene expression at the transcriptional level . Negative_regulation CCND1 MTA3 21209952 2359490 *inhibited* the activation and proliferation of isolated myofibroblasts and down-regulated [cyclin D1] gene expression at the transcriptional level . Negative_regulation CCND1 MTOR 19364503 2065068 Here , we show that inhibition of with its specific inhibitor , rapamycin , suppresses normal thymocyte DNA synthesis by downregulating 4EBP1 , but not S6K , and that 4EBP1 phosphorylation and [cyclin D1] expression are coordinately *increased* in Atm-/- thymocytes . Negative_regulation CCND1 MTOR 23291002 2752427 Since Akt functions as an upstream activator of mechanistic target of rapamycin complex 1 ( mTORC1 ) and is also a downstream target for mTORC2 , the aim of this work was to determine whether is *involved* in thrombin induced RPE cell proliferation by regulating [cyclin D1] expression in immortalized rat RPE-J cell line . Negative_regulation CCND1 MTOR 24626091 2934219 Notably , selective inhibition of *triggered* proteasome mediated [cyclin D1] degradation , suggesting that mTORC2 blockade is responsible for GSK3 dependent reduction of cyclin D1 . Negative_regulation CCND1 MUC1 22318732 2571527 Silencing in human breast cancer cells *down-regulated* activation of the [cyclin D1] promoter and decreased cyclin D1 expression . Negative_regulation CCND1 MUC1 23633115 2790759 We further investigated several MUC1 related molecules of the ß-catenin pathway , and found that the expression of decreased the translocation of ß-catenin into the nucleus , reduced the activity of T cell factor (TCF) and *blocked* the expression of [cyclin D1] and c-Myc . Negative_regulation CCND1 MYC 10551866 565350 By measuring [ ( 3 ) H ] thymidine incorporation , it was found that expression of prolonged the G ( 1 ) phase and *inhibited* up-regulation of [cyclin D1] expression during G ( 1 ) . Negative_regulation CCND1 MYC 12790780 1097547 An antisense mediated decrease in expression *results* in decreased [cyclin D1] expression and inhibition of DNA synthesis , mimicking the effects of antiestrogen treatment and emphasizing the importance of c-Myc as an estrogen/antiestrogen target . Negative_regulation CCND1 MYC 19698176 2133265 Immunoblot analysis showed that expression of protein was significantly downregulated by ApoG2 and that the expression of c-Myc 's downstream molecules [cyclin D1] and cyclin E were *inhibited* whereas p21 was induced . Negative_regulation CCND1 MYC 8196642 259336 Constitutive expression of human *represses* mRNA levels of [cyclin D1] in proliferating BALB/c-3T3 fibroblasts . Negative_regulation CCND1 MYC 8196642 259337 In particular , we found that association with Max is not required for *repression* of [cyclin D1] by in vivo . Negative_regulation CCND1 MYC 8196642 259338 Expression of *represses* the [cyclin D1] promoter via core promoter elements and antagonizes USF mediated transactivation . Negative_regulation CCND1 MYC 8386381 217787 In synchronized cells , *repression* of [cyclin D1] by occurred very early in the G1 phase of the cell cycle . Negative_regulation CCND1 MYLIP 18483394 1939095 This study introduces the *role* of in the regulation of [CCND1] in MCL . Negative_regulation CCND1 MYLIP 19538740 2121204 Of interest , we found that not only suppressed the luciferase activity , but also *suppressed* the endogenous [CCND1] both at protein and mRNA levels . Negative_regulation CCND1 MYLIP 19703993 2144608 Downregulation of in meningiomas and arachnoidal cells *resulted* in increased expression of beta-catenin and [cyclin D1] involved in cell proliferation . Negative_regulation CCND1 MYLIP 20090763 2235408 Concomitant downregulation of and miR-34c substantially *restored* cell cycle progression and expression of [cyclin D1] and Cdk4 . Negative_regulation CCND1 MYLIP 20309880 2362696 In addition , transient transfection of *inhibited* c-Met and [cyclin D1] expression and esophageal cancer cell proliferation , whereas miR-16-2 suppressed RAR-ß ( 2 ) expression and increased tumor cell proliferation . Negative_regulation CCND1 MYLIP 20683643 2329486 In HeLa cells , directly reduced the expression of RND3 at the mRNA and protein levels , which thereby *promoted* expression of the downstream protein [cyclin D1] and increased S-phase entry . Negative_regulation CCND1 MYLIP 22072615 2528262 Furthermore , bioinformatic prediction and experimental validation were used to identify miR-365 target genes and indicated that the antitumor effects of were probably *mediated* by its targeting and repression of [Cyclin D1] and Bcl-2 expression , thus inhibiting cell cycle progression and promoting apoptosis . Negative_regulation CCND1 MYLIP 22491710 2589417 Moreover , *repressed* the expressions of [cyclin D1] and urokinase-type plasminogen activator in A549 cells . Negative_regulation CCND1 MYLIP 22610915 2691414 Up-regulated *resulted* in nuclear accumulation of ß-catenin and a concomitant increase in [cyclin D1] , c-myc , and survivin . Negative_regulation CCND1 MYLIP 22665054 2744842 In previous studies , we demonstrated that miR-193b expression is reduced in melanoma relative to benign nevi , and also that *represses* [cyclin D1] and Mcl-1 expression . Negative_regulation CCND1 MYLIP 22911796 2657378 Additionally , we show that both and miR-133 *reduce* [Cyclin D1] expression and repress myoblast proliferation by inducing G1 phase arrest . Negative_regulation CCND1 MYLIP 23079745 2745145 Bioinformatics analysis of target sites and ectopic expression in HCC cells showed that and miR-125b *suppressed* SIRT7 and [cyclin D1] expression and induced p21 ( WAF1/Cip1 ) -dependent G1 cell cycle arrest . Negative_regulation CCND1 MYLIP 23155254 2699997 *inhibited* expression of [cyclin-D1] , cyclin dependent kinase 4/6 , B-cell lymphoma-2 (BCL-2) and increased cleaved poly ( ADP-ribose ) polymerase ( cPARP ) and cleaved caspase-3 after irradiation . Negative_regulation CCND1 MYLIP 23207154 2705330 The protein levels of [cyclinD1] , cyclinG1 , and E2F1 were significantly *reduced* by both and miR-551b ( P less than 0.001 ) . Negative_regulation CCND1 MYLIP 23223432 2731450 Suppression of miR-193a expands the oncogenic activity of the fusion protein AML-ETO , because *represses* the expression of multiple target genes , such as AML1/ETO , DNMT3a , HDAC3 , KIT , [CCND1] , and MDM2 directly , and increases PTEN indirectly . Negative_regulation CCND1 MYLIP 23298478 2712160 As a consequence , *inhibited* the expression of p-AKT1 , PCNA , [CyclinD1] and MMP-2 , reduced the proliferative activities and invasive potential , and induced cycle arrest in G0/G1 phase in U251 cells . Negative_regulation CCND1 MYLIP 23298779 2733078 The up-regulation of remarkably induced cell cycle arrest and apoptosis , suppressed the tumor cell migration and *inhibited* the target gene expressions such as E2F3 , Bcl-2 , c-myc and [cyclin D1] . Negative_regulation CCND1 MYLIP 23318178 2742351 The transient transfection of pre-miR-30C resulted in greater than 70 % growth inhibition in PC-3 cells and provided strong evidence that selectively *suppresses* the expression of [cyclin D1] and D2 , but not cyclin D3 . Negative_regulation CCND1 MYLIP 23383271 2739535 Restoration of *mediated* down-regulation of [cyclin D1] and Ets1 by transient transfection , rescued the cancer cells from decrease in proliferation , migration and invasion . Negative_regulation CCND1 MYLIP 23598417 2774396 In addition , expression *suppressed* the expression of Wnt5a , cMyc and [cyclin D1] , and increased the phosphorylation of ß-catenin and expression of Caspase 3 , which may contribute to the inhibitory effect of miR-590-5P on cell growth . Negative_regulation CCND1 MYLIP 23740840 2854108 Furthermore , we demonstrated that upregulation *led* to downregulation of [cyclin D1] and c-Myc through inhibition of NF-?B pathway initiated by direct targeting of the IKBKB 3'-untranslated region . Negative_regulation CCND1 MYLIP 23845851 2825082 Meanwhile , also *attenuates* [cyclin D1] and CDKs expression to induce cell cycle arrest . Negative_regulation CCND1 MYLIP 24107628 2878890 In this study , we show that directly targets cyclin D1 and *contributes* to the regulation of [CCND1] gene expression in both myogenic and non-muscle , transformed cells . Negative_regulation CCND1 MYLIP 24107628 2878891 We demonstrate that , either exogenous or endogenous , *reduces* [cyclin D1] levels and proliferation rate in C2C12 cells without promoting differentiation , and that miR-206 knockdown in terminally differentiated C2C12 cells leads to cyclin D1 accumulation in myotubes , indicating that miR-206 might be involved in the maintenance of the post-mitotic state . Negative_regulation CCND1 MYLIP 24333727 2910830 Microarray and Western blotting results showed that significantly *inhibited* CDK1 and [Cyclin D1] gene expression in Ishikawa cells . Negative_regulation CCND1 MYLIP 25111862 2954406 Selective *repression* of the oncogene [cyclin D1] by the tumor suppressor in cancers . Negative_regulation CCND1 MYLK 12773570 1095222 Inhibition of either or Rho kinase blocked sustained ERK signaling , but only Rho kinase inhibition *allowed* for the induction of [cyclin D1] and activation of cdk4 via Rac/Cdc42 . Negative_regulation CCND1 NA 15897899 1433122 or rotenone *reduced* E2-induced [cyclin D1] expression . Negative_regulation CCND1 NAB1 10959623 726269 At inhibitory concentrations ( higher than 1 mM ) *reduced* [cyclin D1] and p53 level in a dose dependent manner and sustained the synthesis of p21waf1/cip1 , probably in a p53 independent way , accounting for the G0/G1 block observed by flow cytometry . Negative_regulation CCND1 NAB2 10959623 726270 At inhibitory concentrations ( higher than 1 mM ) *reduced* [cyclin D1] and p53 level in a dose dependent manner and sustained the synthesis of p21waf1/cip1 , probably in a p53 independent way , accounting for the G0/G1 block observed by flow cytometry . Negative_regulation CCND1 NCK1 21719533 2471292 We have found that adapter protein sequesters PAK1 in the cytoplasm and that coexpression of both PAK1 and Nck *inhibits* the amplifying effect of PRL induced PAK1 on [cyclin D1] promoter activity ( 95 % inhibition ) . Negative_regulation CCND1 NCKIPSD 17407970 1722123 Reporter assays in MCF-7 cells indicated that strongly *inhibited* the transcriptional activities of the [cyclin D1] , c-fos , NF-kappaB , SRE and p21cP1 promoters . Negative_regulation CCND1 NCKIPSD 17407970 1722127 Nevertheless markedly *inhibited* the stimulation of [cyclin D1] promoter activity obtained with trichostatin A [ 1 ] , an inhibitor of HDAC . Negative_regulation CCND1 NCOA1 22542550 2631162 We studied the *role* of PR and in the expression of VEGF , EGFR and [cyclin D1] mediated by P in human astrocytoma cell lines grade III ( U373 ) and IV ( D54 ) . Negative_regulation CCND1 NCOA3 20642839 2297555 SFN induced the expression of and p27/KIP1 , and *inhibited* the expression of [cyclin D1] . Negative_regulation CCND1 NCOA3 21980390 2493072 Resveratrol induced cell cycle arrest by up-regulating the expression of , p27/KIP1 and *inhibiting* the expression of [cyclin D1] . Negative_regulation CCND1 NELFCD 20735431 2324060 Moreover , upregulation of in MDA-MB-231 cells *resulted* in the decrease of [cyclin D1] , ß-catenin , and ERK activity , and the increase of p21 . Negative_regulation CCND1 NEUROG2 22547683 2608440 The use of NEUROG2VP16 and NEUROG2EnR , acting as the constitutive activator and repressor , respectively , indicates that indirectly *represses* [CCND1] and CCNE2 but opens the possibility that CCNE2 is also repressed by a direct mechanism . Negative_regulation CCND1 NFKB1 10464245 640349 Inhibiting by overexpression of an NF-kappaB trans-dominant inhibitor ( nonphosphorylatable IkappaBalpha ) *reduced* [cyclin D1] promoter activation by the Rac1 mutants , placing NF-kappaB in a pathway of Rac1 activation of cyclin D1 . Negative_regulation CCND1 NFKB1 12101248 962566 A reduction in endogenous cyclin D1 levels that coincided with NF-kappaB1 transgene reversal of enhanced nfkb1 ( -/- ) pre-B-cell transformation , coupled with *inhibition* of v-Abl induced kappaB dependent murine [cyclin D1] transcription , lends support to a model in which v-Abl induced cyclin D1 transcription in transformed pre-B cells is controlled by Rel/NF-kappaB dimers with different activities . Negative_regulation CCND1 NFKB1 15489888 1342733 Nonsteroidal anti-inflammatory agents differ in their ability to suppress activation , *inhibition* of expression of cyclooxygenase-2 and [cyclin D1] , and abrogation of tumor cell proliferation . Negative_regulation CCND1 NFKB1 19471891 2085376 target gene expression of apoptotic cell death proteins ( Bax , caspase-3 , caspase-9 ) was significantly enhanced , but the expression of anti-apoptotic genes and cell proliferation marker genes ( Bcl-2 , inhibitor of apoptosis protein ( IAP-1 ) and X chromosome IAP (XIAP) , Cox-2 , c-Fos , c-Jun and [cyclin D1] ) was significantly *inhibited* by the combined treatment compared to Rg3 or docetaxel alone . Negative_regulation CCND1 NFKB1 20596608 2286035 Pre-treatment of NS3 protein expressing cells with ERK inhibitor , PD98059 , blocked the activation of AP-1 and , and *inhibited* [cyclin D1] expression and cell proliferation . Negative_regulation CCND1 NOX1 16987002 1617633 In cycling cells , the effects of Nox1 were dose dependent : levels of Nox1 that induced 3- to 10-fold increases in ROS promoted phosphorylation of ERK1/2 and expression of cyclin D1 , whereas expression of with Noxo1 and Noxa1 ( or expression of Nox4 alone ) that induced substantial increases in intracellular ROS *inhibited* [cyclin D1] and proliferation . Negative_regulation CCND1 NQO2 22266466 2564848 Our results indicate a hitherto unreported *role* of in the control of [AKT/GSK-3ß/cyclin D1] and highlight the involvement of NQO2 in degradation of cyclin D1 , as part of mechanism of chemoprevention by resveratrol . Negative_regulation CCND1 NR1I3 16322332 1487938 Finally , the inhibitory effects of and BAY11-7082 on cyclin D1 expression were not additive - by blocking NF-kappaB CaR activation did not *induce* a further reduction in [cyclin D1] levels . Negative_regulation CCND1 NR3C1 16644723 1575216 The *represses* [cyclin D1] by targeting the Tcf-beta-catenin complex . Negative_regulation CCND1 NR3C1 16644723 1575217 Here we show that in U2OS/GR cells , which are growth arrested by GCs , the *represses* [cyclin D1] via Tcf-beta-catenin , the transcriptional effector of the canonical Wnt pathway . Negative_regulation CCND1 NR4A3 19153266 2032311 Conversely , overexpression of *induces* [cyclin D1] expression and the transcriptional activity of the cyclin D1 promoter in transient reporter assays . Negative_regulation CCND1 NRAS 12202534 983082 The requirement for and the regulatory *role* of ERK2 in [cyclin D1] production and in cell proliferation suggest that the Ras/Raf/MEK/ERK pathway plays a key role in the control of RPE cell proliferation . Negative_regulation CCND1 NRAS 16496386 1554935 Inhibition of by farnesyl thiosalicylic acid *promoted* proteasomal degradation of [cyclin D1] , with a concomitant decrease in phosphorylated retinoblastoma protein accompanied by downregulation of E2F1 and decreased expression of key E2F1 regulated genes critical for cell-cycle progression . Negative_regulation CCND1 NRAS 9407076 470818 Overexpression of dominant negative forms of Ras or RhoA completely blocked PDGF induced p27 ( KIP1 ) degradation , but only dominant negative *inhibited* [cyclin D1] protein expression . Negative_regulation CCND1 ODC1 18330478 1881420 Gene transfection of markedly *down-regulated* expression of ODC and [cyclin D1] , resulting in suppression of proliferation and cell cycle arrest at G0-G1 phase , and the inhibition of colony formation , an anchorage independent growth pattern , and the migratory ability of MDA-MB-231 cells . Negative_regulation CCND1 OSM 12147685 985216 In addition , , an interleukin-6 family cytokine , *down-regulated* the expression of [cyclin D1] and D2 in a primary culture of fetal hepatocytes in which OSM induces hepatic differentiation . Negative_regulation CCND1 PAG1 21092590 2350053 An over-expression of in PC-3M-1E8 cells effectively *suppresses* the activation of Ras and ERK , as well as the [cyclin D1] expression , leading to an inhibition of the proliferation ability of tumor cells . Negative_regulation CCND1 PAK1 14583477 1158989 Such [cyclin D1] promoter activation was *inhibited* by dominant negative forms of Rac1 and . Negative_regulation CCND1 PAK1 15743831 1379102 Furthermore , PAK1 stimulated [cyclin D1] promoter activity was repressed by cotransfection of NF2 , and activity was *inhibited* by expression of merlin . Negative_regulation CCND1 PAK1 21719533 2471293 We have found that adapter protein Nck sequesters PAK1 in the cytoplasm and that coexpression of both and Nck *inhibits* the amplifying effect of PRL induced PAK1 on [cyclin D1] promoter activity ( 95 % inhibition ) . Negative_regulation CCND1 PAK2 15743831 1379103 Furthermore , PAK1 stimulated [cyclin D1] promoter activity was repressed by cotransfection of NF2 , and activity was *inhibited* by expression of merlin . Negative_regulation CCND1 PAK3 15743831 1379104 Furthermore , PAK1 stimulated [cyclin D1] promoter activity was repressed by cotransfection of NF2 , and activity was *inhibited* by expression of merlin . Negative_regulation CCND1 PAK4 15743831 1379100 Furthermore , PAK1 stimulated [cyclin D1] promoter activity was repressed by cotransfection of NF2 , and activity was *inhibited* by expression of merlin . Negative_regulation CCND1 PAK6 15743831 1379101 Furthermore , PAK1 stimulated [cyclin D1] promoter activity was repressed by cotransfection of NF2 , and activity was *inhibited* by expression of merlin . Negative_regulation CCND1 PAK7 15743831 1379099 Furthermore , PAK1 stimulated [cyclin D1] promoter activity was repressed by cotransfection of NF2 , and activity was *inhibited* by expression of merlin . Negative_regulation CCND1 PC 20394812 2262240 Pre-treatment of cells with a proteasome inhibitor ( MG132 ) suppressed *induced* decrease in [cyclin D1] protein levels . Negative_regulation CCND1 PDCD4 22393466 2521056 Conversely , ectopic expression of *inhibited* AKT phosphorylation and [cyclin D1] expression , suggesting that Pdcd4 regulates AKT activity and cyclin D1 expression . Negative_regulation CCND1 PI3 11989975 936446 In this study , we have elucidated differential regulation of the zinc stimulated p21 ( CiP/WAF1 ) and [cyclin D1] *activation* by inhibition of . Negative_regulation CCND1 PIK3C3 12124352 965745 Herceptin induced inhibition of and Akt Is *required* for antibody mediated effects on p27 , [cyclin D1] , and antitumor action . Negative_regulation CCND1 PIK3C3 16353249 1526381 DIM downregulates phosphorylated Akt and and downstream *inhibition* of [cyclin D1] and cdk4 . Negative_regulation CCND1 PIK3R4 12124352 965746 Herceptin induced inhibition of and Akt Is *required* for antibody mediated effects on p27 , [cyclin D1] , and antitumor action . Negative_regulation CCND1 PIK3R4 16353249 1526382 DIM downregulates phosphorylated Akt and and downstream *inhibition* of [cyclin D1] and cdk4 . Negative_regulation CCND1 PIN1 11432833 832058 Overexpression of *increases* cellular [cyclin D1] protein and activates its promoter . Negative_regulation CCND1 PIN1 16820873 1581574 Here , we investigated the *role* of in association with [cyclinD1] in esophageal SCC progression and its clinicopathological significance . Negative_regulation CCND1 PIN1 21443524 2531673 Here , we show that inhibition of by its selective inhibitor juglone *leads* to up-regulation of [cyclinD1] , phospho-tau , and caspase 3 , producing apoptosis in cultured rat hippocampal neurons . Negative_regulation CCND1 PKN1 18515095 1958468 The ( K299A ) mutant also *inhibited* the stimulation of the expression of c-myc and [cyclin D1] , and of cell proliferation and migration , by gastrins . Negative_regulation CCND1 PKN1 21719533 2471294 We have found that adapter protein Nck sequesters in the cytoplasm and that coexpression of both PAK1 and Nck *inhibits* the amplifying effect of PRL induced PAK1 on [cyclin D1] promoter activity ( 95 % inhibition ) . Negative_regulation CCND1 PLK1 18957422 2001147 Activation of *inhibited* TNF induced expression of [cyclin D1] . Negative_regulation CCND1 PML 10763819 683922 whereas , overexpression of *leads* to decreased [cyclin D1] levels . Negative_regulation CCND1 POU2F1 12391146 1001673 In the breast cancer cell line MCF-7 , overexpression of or its POU domain strongly *increases* transcriptional activation of [cyclin D1] and GAL4 reporter genes that is specifically dependent upon CREB but independent of Oct-1 DNA binding . Negative_regulation CCND1 PPARA 16917105 1632844 Using small interfering RNA to decrease endogenous PPARalpha expression , it was determined that was partially *involved* in the [cyclin D1] repression . Negative_regulation CCND1 PPARG 11287611 800234 Herein , liganded by either natural ( 15d-PGJ ( 2 ) and PGD ( 2 ) ) or synthetic ligands ( BRL49653 and troglitazone ) , selectively *inhibited* expression of the [cyclin D1] gene . Negative_regulation CCND1 PPARG 11287611 800235 [Cyclin D1] *repression* by involved competition for limiting abundance of p300 , directed through a c-Fos binding site of the cyclin D1 promoter . Negative_regulation CCND1 PPARG 14764597 1235122 Furthermore activation of *attenuated* [cyclin D1] promoter activity indicating a transcriptional regulation of cyclin D1 . Negative_regulation CCND1 PPARG 14764597 1235124 Since beta-catenin plays a pivotal role in regulating cyclin D1 transcription , we studied whether *mediated* inhibition of [cyclin D1] transcription involved beta-catenin . Negative_regulation CCND1 PPARG 14764597 1235126 Interestingly overexpression of either wild-type or S37A mutant beta-catenin was unable to rescue *mediated* suppression of [cyclin D1] transcription , whereas overexpression of cAMP-response element binding protein ( CREB ) was capable of antagonizing this inhibitory effect of PPARgamma2 . Negative_regulation CCND1 PPARG 14764597 1235127 Additionally pretreatment with okadaic acid antagonized *mediated* inhibition of [cyclin D1] transcription without any effect on beta-catenin expression . Negative_regulation CCND1 PPARG 14764597 1235128 These results indicated that activation *inhibited* [cyclin D1] transcription in hepatocytes via CREB dependent and beta-catenin independent pathways . Negative_regulation CCND1 PPARG 15190077 1280756 Our earlier studies have shown that troglitazone ( TZD ) -mediated activation of in hepatocytes inhibits growth and *attenuates* [cyclin D1] transcription via modulating CREB levels . Negative_regulation CCND1 PPARG 15486348 1366940 Activation of *mediated* curcumin suppression of the expression of [cyclin D1] , a critical protein in the cell cycle , in Moser cells . Negative_regulation CCND1 PPARG 15486348 1366943 Taken together , our results demonstrated for the first time that curcumin activation of inhibited Moser cell growth and *mediated* the suppression of the gene expression of [cyclin D1] and EGFR . Negative_regulation CCND1 PPARG 19075513 2003105 inhibition *promoted* cell proliferation and increased expressions of the c-myc and [cyclin D1] genes and the beta-catenin protein in the colon epithelium . Negative_regulation CCND1 PPARG 19551868 2149561 We also demonstrate that activation *leads* to increased ( p21WAF1/Cip1 and keratin 19 ) or decreased ( [cyclin D1] ) expression of known KLF4 targets , suggesting that KLF4 is a nodal player in a network of PPARgamma regulated genes . Negative_regulation CCND1 PPP3CA 9606972 508316 The inhibitors of and calcium uptake also completely *blocked* the stimulatory effects of lysophosphatidic acid on the expression of cyclins E and A , but not [cyclin D1] . Negative_regulation CCND1 PPP3CB 9606972 508317 The inhibitors of and calcium uptake also completely *blocked* the stimulatory effects of lysophosphatidic acid on the expression of cyclins E and A , but not [cyclin D1] . Negative_regulation CCND1 PPP3CC 9606972 508318 The inhibitors of and calcium uptake also completely *blocked* the stimulatory effects of lysophosphatidic acid on the expression of cyclins E and A , but not [cyclin D1] . Negative_regulation CCND1 PRDX2 15585645 1345660 In the ERalpha positive MCF-7 cell line , *repressed* ERalpha and [cyclin D1] transcription and induced ubiquitin dependent proteasomal degradation of cyclin D1 , leading primarily to G ( 1 ) -S-phase cell cycle arrest . Negative_regulation CCND1 PRDX2 15585645 1345668 Taken together , our data show that effectively *induces* [cyclin D1] down-regulation through both ERalpha dependent and ERalpha independent mechanisms , providing an important new strategy for combating resistance to antiestrogens . Negative_regulation CCND1 PRDX2 18949380 1978832 In addition , markedly *down-regulated* the expression of [cyclin D1] and CDK4 , up-regulated the expression of p21WAF1 and p53 and induced cell cycle arrest at the G1 phase in MCF10A-ras cells . Negative_regulation CCND1 PRKAA1 19440038 2096557 At the molecular level , metformin increases , *reduces* P-EGFR , EGFR , P-MAPK , P-Src , [cyclin D1] and cyclin E ( but not cyclin A or B , p27 or p21 ) , and induces PARP cleavage in a dose- and time dependent manner . Negative_regulation CCND1 PRKAA2 19440038 2096558 At the molecular level , metformin increases , *reduces* P-EGFR , EGFR , P-MAPK , P-Src , [cyclin D1] and cyclin E ( but not cyclin A or B , p27 or p21 ) , and induces PARP cleavage in a dose- and time dependent manner . Negative_regulation CCND1 PRKAB1 19440038 2096559 At the molecular level , metformin increases , *reduces* P-EGFR , EGFR , P-MAPK , P-Src , [cyclin D1] and cyclin E ( but not cyclin A or B , p27 or p21 ) , and induces PARP cleavage in a dose- and time dependent manner . Negative_regulation CCND1 PRKAB2 19440038 2096560 At the molecular level , metformin increases , *reduces* P-EGFR , EGFR , P-MAPK , P-Src , [cyclin D1] and cyclin E ( but not cyclin A or B , p27 or p21 ) , and induces PARP cleavage in a dose- and time dependent manner . Negative_regulation CCND1 PRKAG1 19440038 2096561 At the molecular level , metformin increases , *reduces* P-EGFR , EGFR , P-MAPK , P-Src , [cyclin D1] and cyclin E ( but not cyclin A or B , p27 or p21 ) , and induces PARP cleavage in a dose- and time dependent manner . Negative_regulation CCND1 PRKAG2 19440038 2096562 At the molecular level , metformin increases , *reduces* P-EGFR , EGFR , P-MAPK , P-Src , [cyclin D1] and cyclin E ( but not cyclin A or B , p27 or p21 ) , and induces PARP cleavage in a dose- and time dependent manner . Negative_regulation CCND1 PRKCA 19232344 2054680 expression consistently ( a ) *reduced* steady-state levels of [cyclin D1] by a novel transcriptional mechanism not previously seen in non transformed cells , and ( b ) re-established the ability of PKC agonists to activate the translational repressor 4E-BP1 and inhibit cyclin D1 translation . Negative_regulation CCND1 PRKCA 20141613 2178980 Moreover , activation *repressed* the expression of [cyclin D1] and c-myc , which are known beta-catenin target genes , and thus inhibited the growth of colon cancer cells . Negative_regulation CCND1 PTEN 12917336 1130532 Expression of wild-type but not of mutant forms unable to dephosphorylate phosphoinositides *reduced* the expression of [cyclin D1] . Negative_regulation CCND1 PTEN 12917336 1130533 expression also *prevented* [cyclin D1] from localizing to the nucleus during the G ( 1 ) - to S-phase cell cycle transition . Negative_regulation CCND1 PTGES3 20941532 2364842 Molecular studies showed elevation of Telomerase , viral oncoproteins E6 and E7 , PCNA , p16 , Cyclin D1 in HPV positive cell lines on treatment with estradiol but after treatment with curcumin the level of E7 , PCNA , and [Cyclin D1] was *reduced* but the level of E6 , , and p16 was unaltered . Negative_regulation CCND1 PTGS2 17077316 1684056 The continued increase of ( up to 18 h ) *resulted* in increased intracellular prostaglandin E ( 2 ) and [cyclin D1] expression significantly after 8 and 12 h of EGF treatment . Negative_regulation CCND1 PTGS2 17763946 1858233 Overexpression of did not *increase* expression of [cyclin D1] or phosphoretinoblastoma protein (pRb) , or cleavage of caspase 3 suggesting that this cell cycle mechanism does not mediate COX-2 toxicity in this model . Negative_regulation CCND1 PTGS2 9101092 422998 Taken together , the results demonstrate that TGF-beta 1 strongly induces COX-2 at both the mRNA and protein levels and suggest that this induction of is *involved* in the down-regulation of [cyclin D1] and inhibition of cell growth caused by TGF-beta 1 in rat intestinal epithelial cells . Negative_regulation CCND1 PTH 21852324 2490743 Expressions of pERK1/2 and [cyclin D1] were *inhibited* dramatically by in differentiated osteoblasts from WT mice but much less in osteoblasts from Mkp1 KO mice . Negative_regulation CCND1 PTX3 14500737 1144248 In vivo , similarly *reduces* [cyclin D1] expression in mesangial cells of rats with acute Thy1 glomerulonephritis . Negative_regulation CCND1 PTX4 14500737 1144247 In vivo , similarly *reduces* [cyclin D1] expression in mesangial cells of rats with acute Thy1 glomerulonephritis . Negative_regulation CCND1 RAC1 14583477 1158990 Such [cyclin D1] promoter activation was *inhibited* by dominant negative forms of and PAK1 . Negative_regulation CCND1 RASSF1 12024041 944163 *inhibits* accumulation of native [cyclin D1] , and the RASSF1A induced cell cycle arrest can be relieved by ectopic expression of cyclin D1 or of other downstream activators of the G ( 1 ) /S-phase transition ( cyclin A and E7 ) . Negative_regulation CCND1 RASSF1 15887288 1426604 *induces* cell cycle arrest through inhibition of [cyclin D1] accumulation . Negative_regulation CCND1 RASSF1 19160099 2053970 *induces* cell cycle arrest through inhibition of [cyclin D1] accumulation . Negative_regulation CCND1 RB1 10806303 692117 EGCG induced p21 ( CIP1/WAF1/SDI1 ) , *inhibited* [cyclin D1-associated] pRB kinase activity , and impaired phosphorylation . Negative_regulation CCND1 RB1 8552398 347206 In transformed cell lines , loss of activity strongly correlates with a decrease in cyclin D1 protein expression , and conversely , introduction of pRb can *induce* [cyclin D1] promoter activity . Negative_regulation CCND1 RB1 9584162 505031 Overexpression of *activated* the [cyclin D1] promoter , and a dominant interfering pRB mutant was defective in cyclin D1 promoter activation . Negative_regulation CCND1 RBBP4 14657023 1177212 Removal of the inhibitors from the growth medium of these clones *leads* to downregulation of [cyclin D1] . Negative_regulation CCND1 RBBP7 14657023 1177213 Removal of the inhibitors from the growth medium of these clones *leads* to downregulation of [cyclin D1] . Negative_regulation CCND1 RBL2 16916926 1646378 Suramin , , PD 98059 , and wortmannin *blocked* the ATP induced increase in the [cyclin D1] , cyclin E , cyclin dependent kinase (CDK) 2 , and CDK4 levels . Negative_regulation CCND1 RBMS1 18059167 1839956 In the in vivo setting , YC-1 combined with cisplatin remarkably suppressed tumor growth in a HCC xenograft model , and this effect was also accompanied by *mediated* downregulation of P-Stat3 ( 705 ) , Bcl-xL , [Cyclin D1] and survivin , and induction of cleaved caspase 9 and PARP in the tumor tissues . Negative_regulation CCND1 REL 12897145 1118153 Lastly , stable overexpression of *resulted* in increased [cyclin D1] and NF-kappaB p52 and p50 subunit protein levels . Negative_regulation CCND1 RELA 10464245 640350 Inhibiting by overexpression of an NF-kappaB trans-dominant inhibitor ( nonphosphorylatable IkappaBalpha ) *reduced* [cyclin D1] promoter activation by the Rac1 mutants , placing NF-kappaB in a pathway of Rac1 activation of cyclin D1 . Negative_regulation CCND1 RELA 12101248 962567 A reduction in endogenous cyclin D1 levels that coincided with NF-kappaB1 transgene reversal of enhanced nfkb1 ( -/- ) pre-B-cell transformation , coupled with *inhibition* of v-Abl induced kappaB dependent murine [cyclin D1] transcription , lends support to a model in which v-Abl induced cyclin D1 transcription in transformed pre-B cells is controlled by Rel/NF-kappaB dimers with different activities . Negative_regulation CCND1 RELA 15489888 1342734 Nonsteroidal anti-inflammatory agents differ in their ability to suppress activation , *inhibition* of expression of cyclooxygenase-2 and [cyclin D1] , and abrogation of tumor cell proliferation . Negative_regulation CCND1 RELA 19471891 2085378 target gene expression of apoptotic cell death proteins ( Bax , caspase-3 , caspase-9 ) was significantly enhanced , but the expression of anti-apoptotic genes and cell proliferation marker genes ( Bcl-2 , inhibitor of apoptosis protein ( IAP-1 ) and X chromosome IAP (XIAP) , Cox-2 , c-Fos , c-Jun and [cyclin D1] ) was significantly *inhibited* by the combined treatment compared to Rg3 or docetaxel alone . Negative_regulation CCND1 RELA 20596608 2286036 Pre-treatment of NS3 protein expressing cells with ERK inhibitor , PD98059 , blocked the activation of AP-1 and , and *inhibited* [cyclin D1] expression and cell proliferation . Negative_regulation CCND1 RHO 12773570 1095221 Inhibition of either MLCK or Rho kinase blocked sustained ERK signaling , but only kinase inhibition *allowed* for the induction of [cyclin D1] and activation of cdk4 via Rac/Cdc42 . Negative_regulation CCND1 RHO 16322093 1533066 Lbc stably transfected hepatocarcinoma cells exhibit increased proliferation and levels of ERK and [cyclin D1] activation , which are *blocked* by a inhibitor . Negative_regulation CCND1 RHO 19620284 2124252 Restoring activity , which is downregulated after loss of Cav1 , antagonizes Rac1 and *prevents* [cyclin D1] accumulation after serum starvation or loss of adhesion . Negative_regulation CCND1 RHOA 14726536 1219904 These effects are accompanied by activation of [cyclin D1] transcription and *repression* of the collagen X promoter by . Negative_regulation CCND1 RHOA 14726536 1219905 Dominant negative also *inhibits* induction of the [cyclin D1] promoter by parathyroid hormone related peptide . Negative_regulation CCND1 RHOA 18045963 1832927 Vasopressin triggers senescence in K-ras transformed cells via *dependent* downregulation of [cyclin D1] . Negative_regulation CCND1 RICTOR 24626091 2934218 Notably , selective inhibition of *triggered* proteasome mediated [cyclin D1] degradation , suggesting that mTORC2 blockade is responsible for GSK3 dependent reduction of cyclin D1 . Negative_regulation CCND1 RIN1 15511088 1328202 Expression of Rab5 : S34N and also *block* EGF induction of [cyclin D1] transcription . Negative_regulation CCND1 RND3 20683643 2329487 In HeLa cells , mir-200b directly reduced the expression of at the mRNA and protein levels , which thereby *promoted* expression of the downstream protein [cyclin D1] and increased S-phase entry . Negative_regulation CCND1 RPL19 19799608 2209140 In addition , the suppression of expression by transfection with small interfering RNA *resulted* in the suppression of [cyclinD1] , D3 synthesis , and the growth inhibition of lung cancer cell lines overexpressing RPL19 . Negative_regulation CCND1 RPL34 10049762 592730 also interacts with Cdk4 and , in parallel , *inhibits* the [Cdk4/cyclin D1] activity . Negative_regulation CCND1 RPTOR 19364503 2065067 Here , we show that inhibition of with its specific inhibitor , rapamycin , suppresses normal thymocyte DNA synthesis by downregulating 4EBP1 , but not S6K , and that 4EBP1 phosphorylation and [cyclin D1] expression are coordinately *increased* in Atm-/- thymocytes . Negative_regulation CCND1 RRM2B 21216934 2386382 Conversely , overexpression of *resulted* in an increase in the expression of p21 and decrease in the expression of [cyclin D1] , which correlated with reduced cell population in S-phase in vitro and suppressed growth in vivo . Negative_regulation CCND1 RUNX2 23824099 2854232 Exogenous PTHrP *induced* the expression of [cyclin D1] and Bcl-2 mRNA by various signalling pathways , whereas it inhibited expression through PKA , p38MAPK , MEK and PI3K signalling pathways . Negative_regulation CCND1 SCGB1A1 24106713 2852544 Western blot analysis showed that PDGF-BB induced activation of [cyclin D1] was *inhibited* by . Negative_regulation CCND1 SERPINB5 19728335 2186449 Therefore , in this study , we analyzed the expression of mRNAs encoding components and targets of NF-kappaB signaling including IKKalpha , IKKbeta , RANK , RANKL , OPG , CyclinD3 , mammary serine protease *inhibitor* ( ) , [CyclinD1] , c-FLIP , Bcl-xl , Stat3 , Cip1 and Cip2 by real-time PCR in 40 patients with liver cancer . Negative_regulation CCND1 SERPINF1 17525281 1746207 *reduced* G ( 1 ) cyclin ( [cyclin D1] and E ) expression and increased p27 , a cyclin dependent kinase inhibitor . Negative_regulation CCND1 SETD2 23867319 2865892 *mediated* overexpression of [HO-1/Cyclin D1] facilitates cytoprotection by limiting hepatic inflammatory responses , and hepatocellular necrosis/apoptosis in a PI3K dependent manner . Negative_regulation CCND1 SFN 20642839 2297551 induced the expression of p21/CIP1 and p27/KIP1 , and *inhibited* the expression of [cyclin D1] . Negative_regulation CCND1 SH3D19 18355957 1912638 Down-regulation of expression in MCF-7 cells by shRNA *resulted* in increased cell growth in response to HRG and increased [cyclin D1] and ErbB2 expression . Negative_regulation CCND1 SIAH1 19091460 2041987 The hexachlorophene modulation of and beta-catenin is independent of p53 and *results* in reduced expression of [cyclin-D1] and c-Myc ( target genes of beta-catenin ) , leading to the growth arrest of B lymphoma cells . Negative_regulation CCND1 SIX1 23527134 2761999 Overexpression of upregulates cyclin D1 mRNA and protein , and significantly *enhances* the activity of the [cyclin D1] promoter in PANC-1 cells . Negative_regulation CCND1 SKP2 21931116 2506992 Mechanistically , we show that deficiency *induces* [Cyclin D1] gene expression , which contributes to an increase in HSC cycling . Negative_regulation CCND1 SLC12A9 11371120 817650 The aims of this study were to evaluate the regulatory level of cyclin D1 expression and the relationship between the expression of [cyclin D1] and its *inhibitor* , , and to evaluate their impact on the prognosis of early stage cervical cancer . Negative_regulation CCND1 SLFN11 15946944 1445931 The induction of [cyclin D1] by these stimuli was blocked in the *presence* of as were all downstream cell cycle processes . Negative_regulation CCND1 SLFN12 15946944 1445929 The induction of [cyclin D1] by these stimuli was blocked in the *presence* of as were all downstream cell cycle processes . Negative_regulation CCND1 SLFN13 15946944 1445930 The induction of [cyclin D1] by these stimuli was blocked in the *presence* of as were all downstream cell cycle processes . Negative_regulation CCND1 SLFN14 15946944 1445933 The induction of [cyclin D1] by these stimuli was blocked in the *presence* of as were all downstream cell cycle processes . Negative_regulation CCND1 SLFN5 15946944 1445932 The induction of [cyclin D1] by these stimuli was blocked in the *presence* of as were all downstream cell cycle processes . Negative_regulation CCND1 SMAD4 19544418 2128792 Wnt1 expression was attenuated by Smad4 small interfering RNA ( siRNA ) , and BMP-4 induced [cyclin D1] expression was *inhibited* by and Wnt1 siRNAs . Negative_regulation CCND1 SMARCA4 18239461 1890507 Herein , *inhibited* DNA synthesis and [cyclin D1] expression in human MCF-7 breast cancer epithelial cells . Negative_regulation CCND1 SMARCB1 12138206 969185 Cell cycle arrest and *repression* of [cyclin D1] transcription by . Negative_regulation CCND1 SMARCB1 12138206 969210 In addition , *repressed* transcription of [cyclin D1] gene in MON , in a histone deacetylase (HDAC) dependent manner . Negative_regulation CCND1 SMARCB1 16099835 1448306 We have previously demonstrated that *represses* [Cyclin D1] transcription in rhabdoid cells by directly recruiting histone deacetylase 1 complex to its promoter , leading to G ( 0 ) -G ( 1 ) arrest . Negative_regulation CCND1 SMARCB1 18223228 1864155 , a tumor suppressor biallelically deleted/inactivated in rhabdoid tumors , directly *represses* [cyclin D1] . Negative_regulation CCND1 SMARCB1 21173237 2373662 directly *represses* [CCND1] and activates cyclin dependent kinase (cdk) inhibitors p16(Ink4a) and p21 ( CIP ) . Negative_regulation CCND1 SNORA73A 7784093 309891 We now report that in diploid human fibroblasts functional inactivation of pRB by adenovirus E1A is not sufficient for efficient repression of cyclin D1 gene expression , since the gene product , in addition to E1A , is *required* for repression of the [cyclin D1] gene . Negative_regulation CCND1 SOX17 21957254 2488186 overexpression *inhibited* PDGF induced TOPFLASH and [cyclin D1] promoter activity , and decreased endogenous cyclin D1 , activated ß-catenin , as well as total ß-catenin levels . Negative_regulation CCND1 SOX6 17412698 1760786 Luciferase-reporter assay with beta-catenin showed that *suppresses* [cyclin D1] promoter activities . Negative_regulation CCND1 SOX6 17412698 1760787 By using a histone deacetylase (HDAC) inhibitor and co-immunoprecipitation analysis , we showed that *suppressed* [cyclin D1] activities by interacting withbeta-catenin and HDAC1 . Negative_regulation CCND1 SPHK1 17164439 1716990 Overexpressing human in these cells *resulted* in increased levels of the cell cycle regulator [cyclin D1] and increased myosin light-chain phosphorylation . Negative_regulation CCND1 SPP1 19926637 2198009 Moreover , transfection of cells with wt STAT3 upregulates whereas STAT3 Y705F downregulates Bcl2 and [cyclin D1] expressions in *response* to . Negative_regulation CCND1 SRC 17409427 1722266 Suppression of by RNA interference in NIH3T3-ETV6-NTRK3 cells *resulted* in markedly decreased expression of [cyclin D1] and suppression of activation of Ras-Erk1/2 and PI3K-Akt . Negative_regulation CCND1 SRC 17991742 1851033 Suppression of by RNA interference in highly metastatic 4T1 mammary cancer cells , which express endogenous TrkC , *resulted* in markedly decreased expression of [cyclin D1] and suppression of activation of Ras-Erk1/2 and PI3K-Akt . Negative_regulation CCND1 SRC 18679417 1973319 inhibition *resulted* in decreased binding of beta-catenin to the promoters of G1 phase cell cycle regulators [cyclin D1] and c-Myc. C-Myc may also be regulated at the protein level by extracellular signal regulated kinase 1/2 and GSK3beta . Negative_regulation CCND1 SSFA2 22193592 2543510 The HCS assay also showed that could *inhibit* the EGFR internalization , extracellular-signal regulated kinase ( Erk ) /mitogen activated protein kinase translocation to nucleus , the accumulation of phosphorylated protein kinase B ( Akt ) , signal transducer and activator of transcription 3 ( STAT3 ) , and [cyclin D1] in the nucleus . Negative_regulation CCND1 SST 24828612 2945095 FLNA silencing in human tumoral cells did not affect SST2 expression and localization but abolished the *induced* reduction of [cyclin D1] ( -37 % ± 15 % in control cells , P < .05 vs basal ) and caspase-3/7 activation ( +63 % ± 31 % in control cells , P < .05 vs basal ) . Negative_regulation CCND1 STAT3 12147685 985218 Activation of in fetal hepatocytes of transgenic mice expressing the STAT3-estrogen receptor fusion protein by 4-hydroxytamoxifen *resulted* in the suppression of [cyclin D1] and D2 expression . Negative_regulation CCND1 STAT3 12147685 985220 Furthermore , , a constitutively active form of STAT3 , *suppressed* transcription of the [cyclin D1] promoter in fetal hepatocytes , whereas it activated the transcription in hepatic tumor cells , huH7 and HepG2 . Negative_regulation CCND1 STAT3 16611639 1568866 Furthermore , reduced expression in PC12 cells *suppressed* NGF induced [cyclin D1] expression , thereby inhibiting growth arrest normally triggered by NGF treatment . Negative_regulation CCND1 STAT3 20332458 2230778 Moreover , overexpression of constitutively active *increased* [cyclin D1] transcriptional activity and protein expression , whereas overexpression of a dominant negative STAT3 deletion mutant ( STAT3 ( 1-588 ) ) reduced cyclin D1 transcriptional activity . Negative_regulation CCND1 STAT3 22174819 2518341 Mechanistic characterization revealed that NSC-743380 suppressed the phosphorylation of C-terminal domain of RNA polymerase II , induced JNK activation , *inhibited* phosphorylation and suppressed [cyclin D1] expression in sensitive human cancer cells . Negative_regulation CCND1 STAT3 22216901 2559045 Down regulation of with siRNA *resulted* in a reduced expression of Bcl-2 and [cyclin D1] . Negative_regulation CCND1 STAT3 23800091 2885173 Consequently , the inhibitory effect of EESP on activation *resulted* in an increase in the pro-apoptotic Bax/Bcl-2 ratio , decrease in the expression of the pro-proliferative [Cyclin D1] and CDK4 , as well as down-regulation of pro-angiogenic VEGF-A and VEGFR-2 expression . Negative_regulation CCND1 STK10 21398050 2421208 We have recently revealed that acquired radioresistance of tumor cells induced by fractionated radiation is attributable to cyclin D1 overexpression as a consequence of the downregulation of GSK3ß dependent [cyclin D1] proteolysis *mediated* by a constitutively activated , AKT . Negative_regulation CCND1 STK11 21398050 2421209 We have recently revealed that acquired radioresistance of tumor cells induced by fractionated radiation is attributable to cyclin D1 overexpression as a consequence of the downregulation of GSK3ß dependent [cyclin D1] proteolysis *mediated* by a constitutively activated , AKT . Negative_regulation CCND1 STK16 21398050 2421210 We have recently revealed that acquired radioresistance of tumor cells induced by fractionated radiation is attributable to cyclin D1 overexpression as a consequence of the downregulation of GSK3ß dependent [cyclin D1] proteolysis *mediated* by a constitutively activated , AKT . Negative_regulation CCND1 STK19 21398050 2421211 We have recently revealed that acquired radioresistance of tumor cells induced by fractionated radiation is attributable to cyclin D1 overexpression as a consequence of the downregulation of GSK3ß dependent [cyclin D1] proteolysis *mediated* by a constitutively activated , AKT . Negative_regulation CCND1 STK24 21398050 2421212 We have recently revealed that acquired radioresistance of tumor cells induced by fractionated radiation is attributable to cyclin D1 overexpression as a consequence of the downregulation of GSK3ß dependent [cyclin D1] proteolysis *mediated* by a constitutively activated , AKT . Negative_regulation CCND1 STK25 21398050 2421213 We have recently revealed that acquired radioresistance of tumor cells induced by fractionated radiation is attributable to cyclin D1 overexpression as a consequence of the downregulation of GSK3ß dependent [cyclin D1] proteolysis *mediated* by a constitutively activated , AKT . Negative_regulation CCND1 STK3 21398050 2421214 We have recently revealed that acquired radioresistance of tumor cells induced by fractionated radiation is attributable to cyclin D1 overexpression as a consequence of the downregulation of GSK3ß dependent [cyclin D1] proteolysis *mediated* by a constitutively activated , AKT . Negative_regulation CCND1 STK31 21398050 2421215 We have recently revealed that acquired radioresistance of tumor cells induced by fractionated radiation is attributable to cyclin D1 overexpression as a consequence of the downregulation of GSK3ß dependent [cyclin D1] proteolysis *mediated* by a constitutively activated , AKT . Negative_regulation CCND1 STK33 21398050 2421217 We have recently revealed that acquired radioresistance of tumor cells induced by fractionated radiation is attributable to cyclin D1 overexpression as a consequence of the downregulation of GSK3ß dependent [cyclin D1] proteolysis *mediated* by a constitutively activated , AKT . Negative_regulation CCND1 STK35 21398050 2421218 We have recently revealed that acquired radioresistance of tumor cells induced by fractionated radiation is attributable to cyclin D1 overexpression as a consequence of the downregulation of GSK3ß dependent [cyclin D1] proteolysis *mediated* by a constitutively activated , AKT . Negative_regulation CCND1 STK36 21398050 2421219 We have recently revealed that acquired radioresistance of tumor cells induced by fractionated radiation is attributable to cyclin D1 overexpression as a consequence of the downregulation of GSK3ß dependent [cyclin D1] proteolysis *mediated* by a constitutively activated , AKT . Negative_regulation CCND1 STK38 21398050 2421221 We have recently revealed that acquired radioresistance of tumor cells induced by fractionated radiation is attributable to cyclin D1 overexpression as a consequence of the downregulation of GSK3ß dependent [cyclin D1] proteolysis *mediated* by a constitutively activated , AKT . Negative_regulation CCND1 STK39 21398050 2421220 We have recently revealed that acquired radioresistance of tumor cells induced by fractionated radiation is attributable to cyclin D1 overexpression as a consequence of the downregulation of GSK3ß dependent [cyclin D1] proteolysis *mediated* by a constitutively activated , AKT . Negative_regulation CCND1 STK4 21398050 2421216 We have recently revealed that acquired radioresistance of tumor cells induced by fractionated radiation is attributable to cyclin D1 overexpression as a consequence of the downregulation of GSK3ß dependent [cyclin D1] proteolysis *mediated* by a constitutively activated , AKT . Negative_regulation CCND1 STK40 21398050 2421222 We have recently revealed that acquired radioresistance of tumor cells induced by fractionated radiation is attributable to cyclin D1 overexpression as a consequence of the downregulation of GSK3ß dependent [cyclin D1] proteolysis *mediated* by a constitutively activated , AKT . Negative_regulation CCND1 STRA13 22905217 2648188 SUMO modification of is *required* for repression of [cyclin D1] expression and cellular growth arrest . Negative_regulation CCND1 SUV39H1 19906718 2197647 RNA interference analysis showed that was *critical* for [cyclin D1] repression . Negative_regulation CCND1 SYT1 20061362 2280833 In HT-29 cells , pterostilbene reduced the protein levels of beta-catenin , [cyclin D1] and c-MYC , altered the cellular localization of beta-catenin and *inhibited* the phosphorylation of . Negative_regulation CCND1 SYT1 22309289 2571259 HBx activated Akt phosphorylated its downstream target glycogen synthase kinase 3ß , leading to stabilization of ß-catenin , while phosphorylation *resulted* in enhanced promoter recruitment and expression of target genes encoding [cyclin D1] and Bcl-XL . Negative_regulation CCND1 TAB1 10048449 592530 Western blot analysis demonstrates that the level of [cyclin D1] protein was *regulated* negatively by overexpression of . Negative_regulation CCND1 TAB2 21911473 2496820 Collectively , these data reveal a requisite *role* for the SCF ( Fbx4 ) E3 in regulating [cyclin D1] accumulation , consistent with tumor suppressive function in vivo . Negative_regulation CCND1 TAF1 22711989 2634014 Here we present data demonstrating that disruption of the interaction within TFIID by protein phosphorylation *leads* to activation of TAF1 HAT activity and stimulation of [cyclin D1] and cyclin A gene transcription . Negative_regulation CCND1 TAF7 22711989 2634015 Here we present data demonstrating that disruption of the interaction within TFIID by protein phosphorylation *leads* to activation of TAF1 HAT activity and stimulation of [cyclin D1] and cyclin A gene transcription . Negative_regulation CCND1 TCEAL1 10974928 729346 Moreover P21 ( WAF1 ) as the main cyclin dependent kinases (CDKs) inhibitor may also inhibit the activity of the cyclins , thus overexpression of ( WAF1 ) may *result* in reduced level of [cyclin D1] . Negative_regulation CCND1 TCEAL1 12496058 1026251 It was also found that the expression of ( WAF1/CIP1 ) was significantly induced and the expression of [cyclin D1] and CDK4 was significantly *inhibited* in tea treated groups . Negative_regulation CCND1 TCEAL1 16092977 1443504 Cyclin D1 and were cell cycle regulatory proteins in HSC , and taurine can *inhibit* the HSC [cyclin D1] expression and stimulate P21waf1 expression , facilitate arresting cells in G0/G1 phase , and suppress cell proliferation . Negative_regulation CCND1 TCEAL7 18806825 2000746 Mechanistic investigations revealed that associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally *represses* [cyclin D1] expression . Negative_regulation CCND1 TCF12 10201372 605418 Furthermore , expression of a dominant negative form of in colon-cancer cells strongly *inhibits* expression of [cyclin D1] without affecting expression of cyclin D2 , cyclin E , or cyclin dependent kinases 2 , 4 or 6 . Negative_regulation CCND1 TCF12 12242657 990062 Treatment of one HNSCC cell line ( SNU 1076 ) with anti-Wnt-1 antibodies reduced the activity of the Wnt/Fz dependent transcription factor , and *diminished* the expression of [cyclin D1] and beta-catenin proteins . Negative_regulation CCND1 TCF15 10201372 605419 Furthermore , expression of a dominant negative form of in colon-cancer cells strongly *inhibits* expression of [cyclin D1] without affecting expression of cyclin D2 , cyclin E , or cyclin dependent kinases 2 , 4 or 6 . Negative_regulation CCND1 TCF15 12242657 990063 Treatment of one HNSCC cell line ( SNU 1076 ) with anti-Wnt-1 antibodies reduced the activity of the Wnt/Fz dependent transcription factor , and *diminished* the expression of [cyclin D1] and beta-catenin proteins . Negative_regulation CCND1 TCF19 10201372 605420 Furthermore , expression of a dominant negative form of in colon-cancer cells strongly *inhibits* expression of [cyclin D1] without affecting expression of cyclin D2 , cyclin E , or cyclin dependent kinases 2 , 4 or 6 . Negative_regulation CCND1 TCF19 12242657 990064 Treatment of one HNSCC cell line ( SNU 1076 ) with anti-Wnt-1 antibodies reduced the activity of the Wnt/Fz dependent transcription factor , and *diminished* the expression of [cyclin D1] and beta-catenin proteins . Negative_regulation CCND1 TCF20 10201372 605421 Furthermore , expression of a dominant negative form of in colon-cancer cells strongly *inhibits* expression of [cyclin D1] without affecting expression of cyclin D2 , cyclin E , or cyclin dependent kinases 2 , 4 or 6 . Negative_regulation CCND1 TCF20 12242657 990065 Treatment of one HNSCC cell line ( SNU 1076 ) with anti-Wnt-1 antibodies reduced the activity of the Wnt/Fz dependent transcription factor , and *diminished* the expression of [cyclin D1] and beta-catenin proteins . Negative_regulation CCND1 TCF21 10201372 605422 Furthermore , expression of a dominant negative form of in colon-cancer cells strongly *inhibits* expression of [cyclin D1] without affecting expression of cyclin D2 , cyclin E , or cyclin dependent kinases 2 , 4 or 6 . Negative_regulation CCND1 TCF21 12242657 990066 Treatment of one HNSCC cell line ( SNU 1076 ) with anti-Wnt-1 antibodies reduced the activity of the Wnt/Fz dependent transcription factor , and *diminished* the expression of [cyclin D1] and beta-catenin proteins . Negative_regulation CCND1 TCF23 10201372 605426 Furthermore , expression of a dominant negative form of in colon-cancer cells strongly *inhibits* expression of [cyclin D1] without affecting expression of cyclin D2 , cyclin E , or cyclin dependent kinases 2 , 4 or 6 . Negative_regulation CCND1 TCF23 12242657 990070 Treatment of one HNSCC cell line ( SNU 1076 ) with anti-Wnt-1 antibodies reduced the activity of the Wnt/Fz dependent transcription factor , and *diminished* the expression of [cyclin D1] and beta-catenin proteins . Negative_regulation CCND1 TCF24 10201372 605428 Furthermore , expression of a dominant negative form of in colon-cancer cells strongly *inhibits* expression of [cyclin D1] without affecting expression of cyclin D2 , cyclin E , or cyclin dependent kinases 2 , 4 or 6 . Negative_regulation CCND1 TCF24 12242657 990072 Treatment of one HNSCC cell line ( SNU 1076 ) with anti-Wnt-1 antibodies reduced the activity of the Wnt/Fz dependent transcription factor , and *diminished* the expression of [cyclin D1] and beta-catenin proteins . Negative_regulation CCND1 TCF25 10201372 605427 Furthermore , expression of a dominant negative form of in colon-cancer cells strongly *inhibits* expression of [cyclin D1] without affecting expression of cyclin D2 , cyclin E , or cyclin dependent kinases 2 , 4 or 6 . Negative_regulation CCND1 TCF25 12242657 990071 Treatment of one HNSCC cell line ( SNU 1076 ) with anti-Wnt-1 antibodies reduced the activity of the Wnt/Fz dependent transcription factor , and *diminished* the expression of [cyclin D1] and beta-catenin proteins . Negative_regulation CCND1 TCF3 10201372 605423 Furthermore , expression of a dominant negative form of in colon-cancer cells strongly *inhibits* expression of [cyclin D1] without affecting expression of cyclin D2 , cyclin E , or cyclin dependent kinases 2 , 4 or 6 . Negative_regulation CCND1 TCF3 12242657 990067 Treatment of one HNSCC cell line ( SNU 1076 ) with anti-Wnt-1 antibodies reduced the activity of the Wnt/Fz dependent transcription factor , and *diminished* the expression of [cyclin D1] and beta-catenin proteins . Negative_regulation CCND1 TCF3 22191569 2568780 BME treatment enhanced cellular tumor antigen p53 , cyclin dependent kinase inhibitor 1A ( also called p21 ) , and cyclic AMP dependent levels and *inhibited* [G1/S-specific cyclin D1] , D2 , and D3 , and mitogen activated protein kinase 8 ( also called Janus kinase ) expression , suggesting an additional mechanism involving cell cycle regulation and cell survival . Negative_regulation CCND1 TCF4 10201372 605424 Furthermore , expression of a dominant negative form of in colon-cancer cells strongly *inhibits* expression of [cyclin D1] without affecting expression of cyclin D2 , cyclin E , or cyclin dependent kinases 2 , 4 or 6 . Negative_regulation CCND1 TCF4 12242657 990068 Treatment of one HNSCC cell line ( SNU 1076 ) with anti-Wnt-1 antibodies reduced the activity of the Wnt/Fz dependent transcription factor , and *diminished* the expression of [cyclin D1] and beta-catenin proteins . Negative_regulation CCND1 TCF7 10201372 605425 Furthermore , expression of a dominant negative form of in colon-cancer cells strongly *inhibits* expression of [cyclin D1] without affecting expression of cyclin D2 , cyclin E , or cyclin dependent kinases 2 , 4 or 6 . Negative_regulation CCND1 TCF7 12242657 990069 Treatment of one HNSCC cell line ( SNU 1076 ) with anti-Wnt-1 antibodies reduced the activity of the Wnt/Fz dependent transcription factor , and *diminished* the expression of [cyclin D1] and beta-catenin proteins . Negative_regulation CCND1 TCF7L2 18048388 1861129 Ectopic expression of Dkk3 in lung cancer cells with Dkk3 hypermethylation induced apoptosis and *inhibited* activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and [cyclin D1] . Negative_regulation CCND1 TCF7L2 19089909 2030999 It also inhibited the transcriptional activities of , and USF2 , and *inhibited* the expression of endogenous [cyclin D1] and TGFbeta2 . Negative_regulation CCND1 TCF7L2 22005519 2526410 Moreover , RNAi mediated depletion of endogenous *resulted* in reduced [cyclin D1] promoter activity and protein expression , and the overexpression of TCF7L2 overrode the inhibition of the TCF dependent transcriptional activity and cyclin D1 promoter activity induced by DIF-1 . Negative_regulation CCND1 TERT 20941532 2364841 Molecular studies showed elevation of Telomerase , viral oncoproteins E6 and E7 , PCNA , p16 , Cyclin D1 in HPV positive cell lines on treatment with estradiol but after treatment with curcumin the level of E7 , PCNA , and [Cyclin D1] was *reduced* but the level of E6 , , and p16 was unaltered . Negative_regulation CCND1 TFAP2C 16867219 1592880 expression also *led* to [cyclin D1] repression , decreased Rb phosphorylation , and decreased E2F activity in breast carcinoma cells . Negative_regulation CCND1 TFPI2 21458846 2453524 Western blot assay showed can *inhibit* [cyclinD1] expression and FAK phosphorylation . Negative_regulation CCND1 TGFB1 10454739 638350 *delayed* EGF- or PDGF induced [cyclin D1] expression and blocked the induction of active p42/p44MAPK . Negative_regulation CCND1 TGFB1 10455028 638400 had no effect on the expression of c-myc or p27 ( kip1 ) and weakly *attenuated* the expression of [cyclin D(1)] . Negative_regulation CCND1 TGFB1 10471535 641897 Despite its stimulatory effects on cyclin D1 levels , *inhibited* [cyclin D1-associated] kinase activity and the growth of COLO-357 cells . Negative_regulation CCND1 TGFB1 10906153 713704 *inhibited* PDGF induction of [cyclin D1] protein at 12 h . Negative_regulation CCND1 TGFB1 17482347 1778126 ( TGFbeta ) *reduced* [cyclin D1] levels in the majority of tumors , this effect being not influenced by CaSR activation and menin expression levels . Negative_regulation CCND1 TGFB1 7824270 293210 *inhibits* [cyclin D1] expression in intestinal epithelial cells . Negative_regulation CCND1 TGFB1 9692552 523219 ( TGF-beta1 ) arrests intestinal epithelial cells ( RIE-1 and IEC-6 ) in the G1 phase of the cell cycle and *inhibits* [cyclin D1] expression . Negative_regulation CCND1 TGFB1 9692552 523220 Metabolic labeling studies indicated that *inhibited* [cyclin D1] synthesis without altering the rate of cyclin D1 protein degradation . Negative_regulation CCND1 TGFB1 9692552 523221 These data indicate that *inhibits* the synthesis of [cyclin D1] in gut epithelial cells and that this inhibition is the cause , rather than the result , of TGF-beta1 mediated arrest of intestinal epithelial cell proliferation . Negative_regulation CCND1 TGFB2 17482347 1778127 ( TGFbeta ) *reduced* [cyclin D1] levels in the majority of tumors , this effect being not influenced by CaSR activation and menin expression levels . Negative_regulation CCND1 TGFB3 17482347 1778128 ( TGFbeta ) *reduced* [cyclin D1] levels in the majority of tumors , this effect being not influenced by CaSR activation and menin expression levels . Negative_regulation CCND1 TIMP2 20619141 2286574 After the 24-week drug administration , expressions of several key receptors such as aryl hydrocarbon receptor (AhR) and signal proteins like p53 , cytochrome P450 1A1 (CYP1A1) , proliferating cell nuclear antigen ( PCNA ) , signal transducer and activator of transcription-3 ( Stat-3 ) , survivin , matrix metalloproteinase-2 (MMP-2) , [cyclin D1] , c-myc , tissue *inhibitor* of matrix metalloproteinase-2 ( ) and caspase-3 , and some anti-oxidant markers were studied . Negative_regulation CCND1 TIMP3 23830872 2829163 The binding *led* to a decreased protein level of tumor necrosis factor a , cytoplasmic translocation of NF-?B , and down-regulation of [cyclin D1] . Negative_regulation CCND1 TIPRL 25135222 2957402 These findings suggest that nuclear *induced* downregulation of [cyclin D1] transcription antagonizes EGFR signaling and suppresses tumorigenesis . Negative_regulation CCND1 TJP2 17881732 1823719 [Cyclin D1] is transcriptionally *down-regulated* by via an E box and the transcription factor c-Myc . Negative_regulation CCND1 TJP2 17881732 1823720 Here , we have studied the *role* of , a TJ peripheral protein , in the regulation of [cyclin D1] transcription . Negative_regulation CCND1 TJP2 17881732 1823723 To understand how *represses* [cyclin D1] promoter activity , we used deletion analyses and found that ZO-2 negatively regulates cyclin D1 transcription via an E box and that it diminishes cell proliferation . Negative_regulation CCND1 TLK1 21306487 2410478 Downregulation of levels *results* in undue nuclear accumulation of [cyclin D1] and increased Cdk4 dependent phosphorylation of pRB under quiescence conditions . Negative_regulation CCND1 TLK2 21306487 2410479 Downregulation of levels *results* in undue nuclear accumulation of [cyclin D1] and increased Cdk4 dependent phosphorylation of pRB under quiescence conditions . Negative_regulation CCND1 TMED7 11123288 768679 VCAM-1 ligation activated extracellular signal regulated kinase 2 and *resulted* in increased expression of [cyclin D1] , yet there was neither ( kip1 ) degradation nor an increase in smooth muscle cell DNA synthesis . Negative_regulation CCND1 TMED7 12370811 996098 Collectively , the effects of cyclin D2 overexpression on mammary gland development during pregnancy and involution are attributed to two major factors , altered ( kip1 ) protein level and *inhibition* of [cyclin D1] phosphorylation . Negative_regulation CCND1 TMED7 19153211 2079215 In vivo , azacitidine ( 0.8 mg/kg i.p. ) reduced tumor proliferation and induced apoptosis in both xenografts upmodulating the expression of p16INKA , Bax , Bak , p21/WAF1 , and , and *inhibiting* the activation of Akt activity and the expression of [cyclin D1] , Bcl-2 , and Bcl-XL . Negative_regulation CCND1 TMED7 21209944 2359469 In xenografted tumors , resveratrol upregulated the expressions of TRAIL-R1/DR4 , TRAIL-R2/DR5 , Bax and ( /KIP1 ) , and *inhibited* the expression of Bcl-2 and [cyclin D1] . Negative_regulation CCND1 TMED7 9407076 470815 Overexpression of dominant negative forms of Ras or RhoA completely blocked PDGF induced ( KIP1 ) degradation , but only dominant negative Ras *inhibited* [cyclin D1] protein expression . Negative_regulation CCND1 TNF 16194364 1462861 On the other hand , *inhibited* [cyclin D(1)] expression . Negative_regulation CCND1 TNF 19694904 2151067 In addition , the cell fragments assay and immunofluorescence revealed that *prevented* the translocation of [cyclin D1] into the nucleus , while knocking down SSeCKS alpha isoform expression prompted cyclin D1 redistribution to the nucleus . Negative_regulation CCND1 TNFRSF10A 21209944 2359467 In xenografted tumors , resveratrol upregulated the expressions of , TRAIL-R2/DR5 , Bax and p27 ( /KIP1 ) , and *inhibited* the expression of Bcl-2 and [cyclin D1] . Negative_regulation CCND1 TNFRSF10B 21209944 2359468 In xenografted tumors , resveratrol upregulated the expressions of TRAIL-R1/DR4 , , Bax and p27 ( /KIP1 ) , and *inhibited* the expression of Bcl-2 and [cyclin D1] . Negative_regulation CCND1 TNFSF11 22818895 2646043 We found that PNS *enhanced* the mRNA expression of OPG , ß-catenin , and [cyclin D1] while decreased the mRNA expression of and PPAR?2 . Negative_regulation CCND1 TNP1 7980579 281357 [Cyclin D1] mRNA expression occurring 6 h after stimulation was suppressed in the *presence* of from 2 to 6 h after stimulation . Negative_regulation CCND1 TNP2 7980579 281358 [Cyclin D1] mRNA expression occurring 6 h after stimulation was suppressed in the *presence* of from 2 to 6 h after stimulation . Negative_regulation CCND1 TOB1 12050114 950366 Thus , inhibits cell growth by *suppressing* [cyclin D1] expression , which is canceled by Erk1- and Erk2 mediated Tob phosphorylation . Negative_regulation CCND1 TOB1 12756225 1090670 acts as a transcriptional corepressor and *suppresses* the [cyclin D1] promoter activity through an interaction with histone deacetylase . Negative_regulation CCND1 TOB2 12050114 950367 Thus , inhibits cell growth by *suppressing* [cyclin D1] expression , which is canceled by Erk1- and Erk2 mediated Tob phosphorylation . Negative_regulation CCND1 TOB2 12756225 1090671 acts as a transcriptional corepressor and *suppresses* the [cyclin D1] promoter activity through an interaction with histone deacetylase . Negative_regulation CCND1 TP53 10834541 697784 These findings suggested the hypothesis that prior aberrant expression may affect or *regulate* the overexpression of [cyclin D1] . Negative_regulation CCND1 TP53 11798189 902330 Our results suggest that ectopic wild-type gene transfer *results* in increased [cyclin D1] expression and , consequently , sensitizes human colorectal cancer cells to chemotherapeutic agents . Negative_regulation CCND1 TP53 15297421 1283368 On multivariate analysis , overexpression of [cyclin D1] and combined loss of p21 ( Waf1/Cip1 ) in the *presence* of overexpression were independent predictors of overall survival . Negative_regulation CCND1 TP53 17443686 1760943 We found that the decrease in [cyclin D1] levels induced by NO was GSH-sensitive implying that the redox regulation of NO-mediated cytostasis was a multifaceted process and that both and p53 independent cyclin D1 pathways were *involved* . Negative_regulation CCND1 TP53 19800042 2159484 Importantly , overexpression can *prevent* [cyclin D1] promoter activation by p65 . Negative_regulation CCND1 TP53 20062013 2212063 expression *results* in increased p21 expression , a negative cell-cycle regulatory protein and an inhibitor of [cyclin D1] . Negative_regulation CCND1 TP53 20179194 2215783 Further studies revealed that BME treatment enhanced , p21 , and pChk1/2 and *inhibited* cyclin B1 and [cyclin D1] expression , suggesting an additional mechanism involving cell cycle regulation . Negative_regulation CCND1 TP53 22191569 2568781 BME treatment enhanced , cyclin dependent kinase inhibitor 1A ( also called p21 ) , and cyclic AMP dependent transcription factor-3 levels and *inhibited* [G1/S-specific cyclin D1] , D2 , and D3 , and mitogen activated protein kinase 8 ( also called Janus kinase ) expression , suggesting an additional mechanism involving cell cycle regulation and cell survival . Negative_regulation CCND1 TP53 7784093 309885 The *role* of in coordinated regulation of [cyclin D1] and p21 gene expression by the adenovirus E1A and E1B oncogenes . Negative_regulation CCND1 TRAF6 21911473 2496818 Collectively , these data reveal a requisite *role* for the SCF ( Fbx4 ) E3 in regulating [cyclin D1] accumulation , consistent with tumor suppressive function in vivo . Negative_regulation CCND1 TRG 21144036 2358046 When added in serum containing media , *inhibited* proliferation and [cyclin D1] expression , but was unable to induce any apoptosis . Negative_regulation CCND1 TSC2 9361010 462574 Taken together with our finding that antisense inhibition of *causes* up-regulation of [cyclin D1] expression , these results provide the first evidence for a connection between tuberin/Rap1 and the G1 CDK dependent regulation of the transition from G0/G1 to S phase . Negative_regulation CCND1 TWIST1 18442194 1900491 Overexpression of in MKN28 cells increased Tcf-4/Lef DNA binding activity , and *promoted* expression of Tcf-4 's downstream target genes [cyclin D1] and MMP-2 . Negative_regulation CCND1 UBE2D3 23741361 2797338 ShRNA mediated inhibition of expression attenuated MCF-7 radiosensitivity , and *induced* the accumulation of hTERT and [cyclin D1] in these cells . Negative_regulation CCND1 UBE2V1 21911473 2496819 Collectively , these data reveal a requisite *role* for the SCF ( Fbx4 ) E3 in regulating [cyclin D1] accumulation , consistent with tumor suppressive function in vivo . Negative_regulation CCND1 USF2 19089909 2031000 It also inhibited the transcriptional activities of beta-catenin/TCF4 , and , and *inhibited* the expression of endogenous [cyclin D1] and TGFbeta2 . Negative_regulation CCND1 USP1 19711357 2145143 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP10 19711357 2145144 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP11 19711357 2145145 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP12 19711357 2145188 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP13 19711357 2145146 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP14 19711357 2145147 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP15 19711357 2145148 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP16 19711357 2145149 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP18 19711357 2145150 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP19 19711357 2145151 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP2 19711357 2145152 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP20 19711357 2145153 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP21 19711357 2145154 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP22 19711357 2145155 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP24 19711357 2145156 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP25 19711357 2145157 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP26 19711357 2145165 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP28 19711357 2145158 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP29 19711357 2145167 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP3 19711357 2145159 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP30 19711357 2145175 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP31 19711357 2145170 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP32 19711357 2145168 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP33 19711357 2145169 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP34 19711357 2145176 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP35 19711357 2145171 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP36 19711357 2145172 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP37 19711357 2145173 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP38 19711357 2145177 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP39 19711357 2145181 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP4 19711357 2145160 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP40 19711357 2145179 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP41 19711357 2145180 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP42 19711357 2145178 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP43 19711357 2145182 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP44 19711357 2145174 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP45 19711357 2145187 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP46 19711357 2145183 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP47 19711357 2145184 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP48 19711357 2145166 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP49 19711357 2145185 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP5 19711357 2145161 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP50 19711357 2145186 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP51 19711357 2145189 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP53 19711357 2145191 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP54 19711357 2145190 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP6 19711357 2145162 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP7 19711357 2145163 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 USP8 19711357 2145164 EcR , but not reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by [cyclin D1] . Negative_regulation CCND1 VCAM1 11123288 768678 ligation activated extracellular signal regulated kinase 2 and *resulted* in increased expression of [cyclin D1] , yet there was neither p27 ( kip1 ) degradation nor an increase in smooth muscle cell DNA synthesis . Negative_regulation CCND1 VEGFA 12909331 1121962 Western blot analysis shows that delphinidin reverses the *induced* decrease in expression of cyclin dependent kinase inhibitor p27 ( kip1 ) and the vascular endothelial growth factor induced increase of [cyclin D1] and cyclin A , both being necessary to achieve the G ( 1 ) -to-S transition . Negative_regulation CCND1 VEGFA 19369241 2120038 , on the other hand , *led* to a reduction in [cyclin D1] and to an increase in GSK 3beta and beta-catenin expression which was paralleled by an increase in RPE-specific differentiation markers . Negative_regulation CCND1 VHL 12036906 949164 This suggests a model whereby in some kidney cell types , pVHL may regulate a proliferative response to hypoxia , whereas the loss of *leads* to constitutively elevated [cyclin D1] and abnormal proliferation under normal growth conditions . Negative_regulation CCND1 VHL 12097293 961262 A type 2C pVHL mutant ( V188L ) , which is associated with a PHE only phenotype ( and had been shown previously to retain the ability to promote HIF ubiquitylation ) , retained the ability to suppress CCND1expression suggesting that loss of *mediated* suppression of [cyclin D1] is not necessary for PHE development in VHL disease . Negative_regulation CCND1 VHL 12743597 1088452 Taken together , these observations indicate that is *required* for the downregulation of [cyclinD1] at a high cell density through HIF . Negative_regulation CCND1 WNK1 21056029 2354531 NF-?B *represses* ß-catenin activated transcription of [cyclin D1] . Negative_regulation CCND1 WNT1 19544418 2128791 expression was attenuated by Smad4 small interfering RNA ( siRNA ) , and BMP-4 induced [cyclin D1] expression was *inhibited* by Smad4 and Wnt1 siRNAs . Negative_regulation CCND1 WNT1 20739273 2336028 We analyzed that inhibition of signaling by p15RS *leads* to decreased expression of [CYCLIN D1] and c-MYC , two Wnt targeted genes critical for cell growth . Negative_regulation CCND1 WNT1 20856206 2381658 One of such molecules is V3Nter , a soluble SFRP-like frizzled polypeptide that binds to Wnt3a and *inhibits* signaling and expression of the ß-catenin target genes [cyclin D1] and c-myc. V3Nter is derived from the cell surface extracellular matrix component collagen XVIII . Negative_regulation CCND1 WNT11 20739273 2336029 We analyzed that inhibition of signaling by p15RS *leads* to decreased expression of [CYCLIN D1] and c-MYC , two Wnt targeted genes critical for cell growth . Negative_regulation CCND1 WNT11 20856206 2381659 One of such molecules is V3Nter , a soluble SFRP-like frizzled polypeptide that binds to Wnt3a and *inhibits* signaling and expression of the ß-catenin target genes [cyclin D1] and c-myc. V3Nter is derived from the cell surface extracellular matrix component collagen XVIII . Negative_regulation CCND1 WNT16 20739273 2336034 We analyzed that inhibition of signaling by p15RS *leads* to decreased expression of [CYCLIN D1] and c-MYC , two Wnt targeted genes critical for cell growth . Negative_regulation CCND1 WNT16 20856206 2381664 One of such molecules is V3Nter , a soluble SFRP-like frizzled polypeptide that binds to Wnt3a and *inhibits* signaling and expression of the ß-catenin target genes [cyclin D1] and c-myc. V3Nter is derived from the cell surface extracellular matrix component collagen XVIII . Negative_regulation CCND1 WNT2 20739273 2336030 We analyzed that inhibition of signaling by p15RS *leads* to decreased expression of [CYCLIN D1] and c-MYC , two Wnt targeted genes critical for cell growth . Negative_regulation CCND1 WNT2 20856206 2381660 One of such molecules is V3Nter , a soluble SFRP-like frizzled polypeptide that binds to Wnt3a and *inhibits* signaling and expression of the ß-catenin target genes [cyclin D1] and c-myc. V3Nter is derived from the cell surface extracellular matrix component collagen XVIII . Negative_regulation CCND1 WNT3 20739273 2336031 We analyzed that inhibition of signaling by p15RS *leads* to decreased expression of [CYCLIN D1] and c-MYC , two Wnt targeted genes critical for cell growth . Negative_regulation CCND1 WNT3 20856206 2381661 One of such molecules is V3Nter , a soluble SFRP-like frizzled polypeptide that binds to Wnt3a and *inhibits* signaling and expression of the ß-catenin target genes [cyclin D1] and c-myc. V3Nter is derived from the cell surface extracellular matrix component collagen XVIII . Negative_regulation CCND1 WNT3A 22876125 2641498 Overexpression of *resulted* in upregulated expression of ß-catenin , c-Myc , and [cyclin D1] . Negative_regulation CCND1 WNT4 12707392 1082889 In addition , the overexpression of and beta-catenin promoted the cell cycle and *increased* the promoter activity and protein expression of [cyclin D1] in LLC-PK1 cells . Negative_regulation CCND1 WNT4 20739273 2336032 We analyzed that inhibition of signaling by p15RS *leads* to decreased expression of [CYCLIN D1] and c-MYC , two Wnt targeted genes critical for cell growth . Negative_regulation CCND1 WNT4 20856206 2381662 One of such molecules is V3Nter , a soluble SFRP-like frizzled polypeptide that binds to Wnt3a and *inhibits* signaling and expression of the ß-catenin target genes [cyclin D1] and c-myc. V3Nter is derived from the cell surface extracellular matrix component collagen XVIII . Negative_regulation CCND1 WNT6 20739273 2336033 We analyzed that inhibition of signaling by p15RS *leads* to decreased expression of [CYCLIN D1] and c-MYC , two Wnt targeted genes critical for cell growth . Negative_regulation CCND1 WNT6 20856206 2381663 One of such molecules is V3Nter , a soluble SFRP-like frizzled polypeptide that binds to Wnt3a and *inhibits* signaling and expression of the ß-catenin target genes [cyclin D1] and c-myc. V3Nter is derived from the cell surface extracellular matrix component collagen XVIII . Negative_regulation CCND1 ZBTB17 16537485 1536657 Both [cyclin D1] down-regulation and the G ( 1 ) slowdown induced by the transposase *require* . Negative_regulation CCND1 ZFX 24448637 2918181 Depletion of decreased the phosphorylation level of AKT and *increased* the phosphorylation level of ERK2 and the expression of [cyclin D1] , which is involved in cell survival and cell cycle regulation . Negative_regulation CCND2 EPHB2 16210359 1501030 The present study therefore shows that the inhibitory effect of DHT on insulin stimulated granulosa cell proliferation occurs early in the signaling pathway at the level of insulin receptor substrate-1 phosphorylation , leading to reduced phosphorylation and subsequent *inhibition* of [cyclin D2] mRNA expression . Negative_regulation CCND3 CDKN1C 15294951 1279029 Induction of *resulted* in increased association of cdk6 with [cyclin D3] , without receptor mediated T cell stimulation . Negative_regulation CCND3 IFI27 15665120 1395344 This novel feature of the binding specificity of p27 ( kip1 ) to cyclins and cdk 's in vivo is interpreted in the context of overexpression of [cyclin D3] in the *presence* of high levels of ( kip1 ) in human B-cell lymphomas with adverse clinical outcome . Negative_regulation CCNE1 IFI27 10896783 711674 Evaluation of the kinase activity of cyclin-Cdk complexes showed that RA increases ( Kip1 ) expression in CH27 cells leading to markedly reduced cyclin A/Cdk2 kinase activity and slightly *reduced* [cyclin E/Cdk2] kinase activity , with no effect on cyclin D/Cdk4 and cyclin D/Cdk6 activities . Negative_regulation CCR1 TNF 10496320 647186 *down-regulated* CC [chemokine receptor (CCR)1] , CCR2 , and CCR5 and up-regulated CCR7 mRNA levels , in agreement with functional data . Negative_regulation CCR1 TNF 10679062 668579 Stimulation of mature DCs with TGF-beta 1 also enhanced *induced* down-regulation of the expressions of [CCR-1] , CCR-3 , CCR-5 , CCR-6 , and CXCR-4 , and chemotaxis to their respective ligands , while this stimulation suppressed TNF-alpha induced expression of CCR-7 and chemotactic migratory ability to MIP-3 beta . Negative_regulation CCR1 TNF 18178867 1856463 Stimulation of ASMC with and , to a lesser extent , IFN-gamma *resulted* in an up-regulation of [CCR1] expression , which was totally suppressed by both dexamethasone or mithramycin . Negative_regulation CCR2 EPHB2 19224633 2044684 MCP-2/CCL8 ( 6-75 ) induced internalization of CCR2 , *inhibited* MCP-1/CCL2 and MCP-2/CCL8 signaling and antagonized the chemotactic activity of several [CCR2] ligands ( MCP-1/CCL2 , MCP-2/CCL8 , MCP-3/CCL7 ) . Negative_regulation CCR2 TNF 10496320 647187 *down-regulated* CC chemokine receptor (CCR)1 , [CCR2] , and CCR5 and up-regulated CCR7 mRNA levels , in agreement with functional data . Negative_regulation CCR2 TNF 15517610 1343155 Inhibition of [CCR2] directly augmented Toll-like receptor *induced* IL-10 , but not and IL-6 , production of macrophages in vitro . Negative_regulation CCR3 IL1B 12004163 939981 Given the association of chemokine receptors with progression to diabetes , it appears that *induced* down-regulation of [CCR3] and CCR5 promotes a protective mechanism against cellular destruction . Negative_regulation CCR3 TNF 10679062 668585 Stimulation of mature DCs with TGF-beta 1 also enhanced *induced* down-regulation of the expressions of CCR-1 , [CCR-3] , CCR-5 , CCR-6 , and CXCR-4 , and chemotaxis to their respective ligands , while this stimulation suppressed TNF-alpha induced expression of CCR-7 and chemotactic migratory ability to MIP-3 beta . Negative_regulation CCR5 IL1B 12004163 939982 Given the association of chemokine receptors with progression to diabetes , it appears that *induced* down-regulation of CCR3 and [CCR5] promotes a protective mechanism against cellular destruction . Negative_regulation CCR5 STAT4 11739505 886520 A mandatory *role* for in IL-12 induction of mouse T cell [CCR5] . Negative_regulation CCR5 STAT4 11739505 886531 Considering that STAT4 is the most critical of IL-12 signaling molecules , this study investigated the *role* for in the induction of [CCR5] expression . Negative_regulation CCR5 TNF 10496320 647188 *down-regulated* CC chemokine receptor (CCR)1 , CCR2 , and [CCR5] and up-regulated CCR7 mRNA levels , in agreement with functional data . Negative_regulation CCR5 TNF 10716998 676636 In contrast , xanthine/xanthine oxidase opposed the bacterial lipopolysaccharide- and *mediated* inhibition of [CCR5] and CXCR4 mRNA expression and increased both the CCR5 surface expression and the cell migration ( 3-fold ) in response to macrophage inflammatory protein-1beta . Negative_regulation CCR5 TNF 10820380 694468 In the *presence* of IL-13 and , expression of [CCR5] was completely abrogated while the expression of CD4 and CXCR4 remained significantly reduced as compared to untreated controls . Negative_regulation CCR5 TNF 10843668 700092 In this study , we report that *delays* the surface expression of [CCR5] on PBLs after activation and diminishes CCR5 irrespective of its initial level . Negative_regulation CCR5 TNF 11023494 738295 LPS stimulated up-regulation of CXCR4 and [CCR5] in vitro was *inhibited* by and anti-IFN gamma . Negative_regulation CCR6 TNF 10577517 569531 Down-regulation of the beta-chemokine receptor [CCR6] in dendritic cells *mediated* by and IL-4 . Negative_regulation CCR6 TNF 10679062 668591 Stimulation of mature DCs with TGF-beta 1 also enhanced *induced* down-regulation of the expressions of CCR-1 , CCR-3 , CCR-5 , [CCR-6] , and CXCR-4 , and chemotaxis to their respective ligands , while this stimulation suppressed TNF-alpha induced expression of CCR-7 and chemotactic migratory ability to MIP-3 beta . Negative_regulation CCR7 EPHB2 17179222 1717268 Specific inhibition of during CB DC maturation *enhanced* LPS induced up-regulation of [CCR7] and CXCR4 on CB DCs and their chemotaxis toward CCL19 and CXCL12 , to a level similar to that of mature AB DCs . Negative_regulation CCR7 SELL 22387549 2572518 Notably , ligation of and/or CCR7 did not *result* in increased [CCR7] expression levels , internalization , or re-expression . Negative_regulation CCR7 TNF 12436111 1016128 Defective localization was attributable to *dependent* , interleukin 10-mediated inhibition of [CCR7] expression . Negative_regulation CCR9 TNF 23460364 2799483 or TGF-ß1 antagonism *attenuated* [CCR9] ( + ) macrophage induced HSC activation . Negative_regulation CCT CA12 23289904 2786293 Supposedly , prostaglandin analogs (PGA) could reduce the central corneal thickness (CCT) , while topical inhibitors ( TCAI ) could *increase* [CCT] . Negative_regulation CD14 ADAM11 22155193 2548653 Moreover , activation of monocytes and with live BCG *reduced* expression levels of [CD14] and CD11c , respectively , necessitating optimization of staining conditions to reliably measure these lineage markers . Negative_regulation CD14 APOB 9863542 556104 In addition , *inhibited* IL-1 and TNF production and the expression of CD11a , CD11b , CD11c and [CD14] by the mononuclear cells of FH patients and this may be an additional beneficial effect of LDL-apheresis apart of decreasing LDL concentrations . Negative_regulation CD14 ARID4B 9759883 536614 Performing gel filtration of FITC labeled ReLPS incubated with soluble CD14 , we showed that could not *prevent* binding of LPS to soluble [CD14] , in contrast to pep27-39 . Negative_regulation CD14 CCL2 9561931 500539 However , stimulation of monocytes with *resulted* only in upregulation of the expression of [CD14] on monocytes from symptomatic asthma patients but not on monocytes from asymptomatic asthma patients and healthy individuals . Negative_regulation CD14 CD19 11606028 871561 or anti-CD79b antibody *blocked* B cell proliferation and [anti-CD14] or anti-CD 11b antibody decreased macrophage NO production , indicating the possible cellular binding sites of PG . Negative_regulation CD14 CD4 15937058 1427470 Interestingly , neither mAbs nor recombinant soluble CD4 ( sCD4 ) receptor could *block* IL-10 secretion induced by HIV-1 ( 213 ) , HIV-1 ( BaL ) or HIV-1 gp160 in [CD14] ( + ) monocytes , whereas anti-CD4 mAb or sCD4 almost completely blocked the secretion of the other cytokines . Negative_regulation CD14 CEBPA 10438498 634841 These data indicate that is directly *involved* in the regulation of [CD14] gene expression . Negative_regulation CD14 CISH 19846417 2165323 Complimentary in vitro experiments to determine the specificity of the effect showed that synthetic , trans11-CLA *suppressed* surface expression of [CD14] and TLR4 on BMDC . Negative_regulation CD14 CRP 17051617 1642002 *impairs* human [CD14+] monocyte derived dendritic cell differentiation , maturation and function . Negative_regulation CD14 CSF2 10766183 684355 Granulocyte macrophage and interleukin 4 *enhance* the number and antigen presenting activity of circulating [CD14+] and CD83+ cells in cancer patients . Negative_regulation CD14 CSF2 11012779 736214 Release of [CD14] in the culture supernatant was decreased in the *presence* of , suggesting that a reduced shedding was responsible for the effect of GM-CSF on CD14 expression . Negative_regulation CD14 CSF2 11477201 841988 Down-regulation of [CD14] expression in *response* to IL-4 and was slower in cord blood monocytes than that in adult peripheral blood monocytes . Negative_regulation CD14 CSF2 8543833 346271 In contrast to these cytokines , IFN-gamma suppressed LPS induced histamine production regardless of whether it was stimulated by or IL-3 , and *inhibited* [CD14] expression . Negative_regulation CD14 CSF2 8911145 395288 *down-regulated* the membrane expression of [CD14] on monocytes while it up-regulated expression on neutrophils . Negative_regulation CD14 EDNRA 10229544 611043 Flow cytometric analysis showed that markedly *reduced* the expression of [CD14] and CD11c/CD18 on the surface of AMs . Negative_regulation CD14 ELANE 11067940 747597 This reduction of CD14 resulted from direct proteolysis by HLE on the cell surface , because *reduced* [CD14] on fixed HGF and also on purified cell membranes . Negative_regulation CD14 FRMD6 8759762 377962 The binding to [CD14+] and CD117+ cells could be *blocked* by rC5a and by peptide representing amino acid residues 1-31 of the C5aR . Negative_regulation CD14 GPX1 20219985 2281571 We have found that suppression of in human microvascular endothelial cells *increases* [CD14] gene expression compared to untreated or siControl ( siCtrl ) -treated conditions . Negative_regulation CD14 GPX1 20219985 2281572 Following LPS treatment , deficiency *augmented* LPS induced intracellular reactive oxygen species accumulation , [CD14] expression , and intercellular adhesion molecule-1 ( ICAM-1 ) mRNA and protein expression compared to LPS treated control cells . Negative_regulation CD14 HDAC1 9759883 536618 Performing gel filtration of FITC labeled ReLPS incubated with soluble CD14 , we showed that could not *prevent* binding of LPS to soluble [CD14] , in contrast to pep27-39 . Negative_regulation CD14 HDAC2 9759883 536619 Performing gel filtration of FITC labeled ReLPS incubated with soluble CD14 , we showed that could not *prevent* binding of LPS to soluble [CD14] , in contrast to pep27-39 . Negative_regulation CD14 IFNG 1380987 196024 The effect of the cytokines interferon-gamma (IFN-gamma) , tumor necrosis factor alpha (TNF alpha) , granulocyte monocyte colony stimulating factor ( GM-CSF ) and interleukin 1 (IL-1) on the expression of CD14 or HLA-DR was different : strongly upregulated HLA-DR expression and *down-regulated* [CD14] expression while TNF alpha , GM-CSF and IL-1 mainly stimulated CD14 expression on bone marrow mononuclear cells . Negative_regulation CD14 IFNG 1431309 202881 Monocytes were cultured for 48 h with IFN-gamma alone or for 24 h with IFN-gamma followed by LPS for a second 24 h . alone *caused* a down-regulation of [CD14] expression , as assessed by flow cytometry , relative to CD14 expression in untreated monocytes . Negative_regulation CD14 IFNG 8872897 389713 Surface [CD14] expression can be *down-regulated* by interaction with its ligand lipopolysaccharide (LPS) , and by the T-helper ( Th1 ) cytokine or the Th2 cytokine interleukin-4 (IL-4) . Negative_regulation CD14 IL13 10023859 590785 As evidenced by flow cytometry , in the in vitro cell cultures was physiologically active and *suppressed* [CD14] expression , while it enhanced the expression of CD23 on human monocytes . Negative_regulation CD14 IL13 11278629 802715 It also inhibited IL-13 induced STAT-6 ( signal transduction and activator of transducer-6 ) activation in immune cells and cancer cells and reversed *induced* inhibition of [CD14] expression on human primary monocytes . Negative_regulation CD14 IL13 7542068 310928 *inhibited* [CD14] expression on human monocytes . Negative_regulation CD14 IL13 7545713 323051 dose-dependently *inhibited* [CD14] expression on human monocytes . Negative_regulation CD14 IL13 7545713 323052 *dependent* down-regulation of [CD14] resulted in the inhibition of CD14 mediated events . Negative_regulation CD14 IL1A 15760549 1383242 Glycine could efficiently protect rat liver grafts from ischemia-reperfusion injury by repressing the expression of [CD14] and NF-kappa B binding activity in Kupffer cells and *inhibiting* the productions of TNF alpha and . Negative_regulation CD14 IL3 8543833 346272 In contrast to these cytokines , IFN-gamma suppressed LPS induced histamine production regardless of whether it was stimulated by GM-CSF or , and *inhibited* [CD14] expression . Negative_regulation CD14 IL4 10766183 684356 Granulocyte macrophage colony stimulating factor and *enhance* the number and antigen presenting activity of circulating [CD14+] and CD83+ cells in cancer patients . Negative_regulation CD14 IL4 11477201 841989 Down-regulation of [CD14] expression in *response* to and GM-CSF was slower in cord blood monocytes than that in adult peripheral blood monocytes . Negative_regulation CD14 IL4 1701391 145032 Nuclear run-off assays revealed that the *dependent* down-regulation of [CD14] resulted from decreased transcription . Negative_regulation CD14 IL4 7522293 269631 However , upregulation of [CD14] and MSE mRNA expression in the cell line by a 2-day incubation with LPS were *inhibited* by . Negative_regulation CD14 IL4 7559810 324102 In addition , *inhibited* expression of [CD14] , which is a receptor for LPS bound to the LPS binding protein (LBP) . Negative_regulation CD14 IL4 7691031 228706 *induces* down-regulation of [CD14] expression on human monocytes only when the cells are cultured with serum . Negative_regulation CD14 IL4 8872897 389714 Surface [CD14] expression can be *down-regulated* by interaction with its ligand lipopolysaccharide (LPS) , and by the T-helper ( Th1 ) cytokine interferon-gamma (IFN-gamma) or the Th2 cytokine . Negative_regulation CD14 IL4 9014829 405437 Paralleling the situation in peripheral blood monocytes ( PBMo ) , recombinant human *down-regulated* the expression of [CD14] on the cell surface of MUTZ-3 , but not that of MONO-MAC-6 cells . Negative_regulation CD14 INHBA 18321725 1891890 In addition , could obviously *reduce* the expressions of CD68 and [CD14] , as well as Toll-like receptor 4 (TLR4) on RAW264.7 cells induced by LPS , but could not influence the proliferation of RAW264.7 cells . Negative_regulation CD14 INHBA 19091310 2031040 Furthermore , remarkably *inhibited* the expressions of [CD14] and MHC II on LPS induced mouse peritoneal macrophages , but had no significant effect on the expression of MHC I and the proliferation of mouse peritoneal macrophages . Negative_regulation CD14 LBP 15618154 1357608 Here , we report that human high-dose ( hd-LBP ) *suppresses* binding of both R-type and S-type LPS to [CD14] and inhibits LPS induced nuclear translocation of NF-kappaB , although cellular uptake of R-type LPS was found to be increased by hd-LBP . Negative_regulation CD14 LGALS9 21562126 2458866 *down-regulated* [CD14] on pDC-like macrophages from PBS treated mice independently of Gal-9/Tim-3 ( T-cell immunoglobulin- and mucin domain containing molecule-3 ) interaction , resulting in the acquisition of suppressive function , suggesting that the loss of CD14 by Gal-9 is critical for the suppression of pDC-like macrophages . Negative_regulation CD14 MSH2 14572638 1155906 Anti-CD14 antibody was unable to protect *mediated* downregulation of [CD14] . Negative_regulation CD14 MSH3 14572638 1155907 Anti-CD14 antibody was unable to protect *mediated* downregulation of [CD14] . Negative_regulation CD14 MSH4 14572638 1155908 Anti-CD14 antibody was unable to protect *mediated* downregulation of [CD14] . Negative_regulation CD14 MSH5 14572638 1155909 Anti-CD14 antibody was unable to protect *mediated* downregulation of [CD14] . Negative_regulation CD14 MSH6 14572638 1155910 Anti-CD14 antibody was unable to protect *mediated* downregulation of [CD14] . Negative_regulation CD14 MTX1 10219258 609100 The generation of [CD14] ( + ) cells from RA bone marrow CD14 ( - ) progenitor cells was significantly *suppressed* by . Negative_regulation CD14 NFKB1 15618154 1357609 Here , we report that human high-dose LBP ( hd-LBP ) suppresses binding of both R-type and S-type LPS to [CD14] and *inhibits* LPS induced nuclear translocation of , although cellular uptake of R-type LPS was found to be increased by hd-LBP . Negative_regulation CD14 PTX3 1596574 188745 Basal [CD14] and CD11b expression were slightly *reduced* by DEX and , but neither drug modified the acivicin induced increases . Negative_regulation CD14 PTX4 1596574 188744 Basal [CD14] and CD11b expression were slightly *reduced* by DEX and , but neither drug modified the acivicin induced increases . Negative_regulation CD14 RBBP4 9759883 536620 Performing gel filtration of FITC labeled ReLPS incubated with soluble CD14 , we showed that could not *prevent* binding of LPS to soluble [CD14] , in contrast to pep27-39 . Negative_regulation CD14 RBBP7 9759883 536621 Performing gel filtration of FITC labeled ReLPS incubated with soluble CD14 , we showed that could not *prevent* binding of LPS to soluble [CD14] , in contrast to pep27-39 . Negative_regulation CD14 RELA 15618154 1357610 Here , we report that human high-dose LBP ( hd-LBP ) suppresses binding of both R-type and S-type LPS to [CD14] and *inhibits* LPS induced nuclear translocation of , although cellular uptake of R-type LPS was found to be increased by hd-LBP . Negative_regulation CD14 SAP130 9759883 536617 Performing gel filtration of FITC labeled ReLPS incubated with soluble CD14 , we showed that could not *prevent* binding of LPS to soluble [CD14] , in contrast to pep27-39 . Negative_regulation CD14 SAP30 9759883 536613 Performing gel filtration of FITC labeled ReLPS incubated with soluble CD14 , we showed that could not *prevent* binding of LPS to soluble [CD14] , in contrast to pep27-39 . Negative_regulation CD14 SIN3A 9759883 536615 Performing gel filtration of FITC labeled ReLPS incubated with soluble CD14 , we showed that could not *prevent* binding of LPS to soluble [CD14] , in contrast to pep27-39 . Negative_regulation CD14 SLCO6A1 2154231 127442 We found that inhibited the capacity of HL-60 cells to produce C2 but did not *inhibit* the expression of [CD14] . Negative_regulation CD14 SLCO6A1 9281388 451464 The generation of [CD14] ( + ) cells from RA bone marrow CD14 ( - ) progenitor cells was significantly *suppressed* by , but not by BUC-ID . Negative_regulation CD14 STAT1 15944287 1416137 Finally , interfering RNA *inhibited* IL-10 induced [CD14] expression . Negative_regulation CD14 SUDS3 9759883 536616 Performing gel filtration of FITC labeled ReLPS incubated with soluble CD14 , we showed that could not *prevent* binding of LPS to soluble [CD14] , in contrast to pep27-39 . Negative_regulation CD14 TAL1 18436863 1920979 Decreased expression in CMP *resulted* in rare erythroid colonies , in a 2-3 fold reduction of GM colony number in clonogenic assays and in a 3.6-5.6 decreased production of [CD14] ( + ) CD15 ( + ) GM cells in liquid culture . Negative_regulation CD14 TGFB1 10768925 685056 Since TGF-beta1 pretreatment inhibited LPS stimulated expression of c-fos and c-jun genes and also the binding of nuclear proteins to the consensus sequence of the binding site for activation protein 1 (AP-1) , a heterodimer of c-Fos and c-Jun , in the cells , *inhibition* of [CD14] expression may be a consequence of downregulation of AP-1 . Negative_regulation CD14 TLR9 15627643 1349324 On the other hand , expression was decreased by SiO ( 2 ) nano-particles , and expression of the co-receptor [CD14] was *inhibited* by Co nanoparticles . Negative_regulation CD14 TNF 15256426 1322061 Using neutralizing antibodies against m-CSF-1R or its ligand , we found that inhibiting this pathway strongly reduced [CD14] expression in *response* to RA and , suggesting that this pathway is essential for their synergy in RA-resistant leukemia cells . Negative_regulation CD14 TNF 15760549 1383241 Glycine could efficiently protect rat liver grafts from ischemia-reperfusion injury by repressing the expression of [CD14] and NF-kappa B binding activity in Kupffer cells and *inhibiting* the productions of and IL-1 . Negative_regulation CD14 TOP1 7510956 250011 We conclude that inhibition of *enhances* vitamin D3-stimulated [CD 14] expression . Negative_regulation CD14 TYR 17977838 1850281 These findings reveal *roles* of Phe ( 121 ) and ( 131 ) in TLR4 independent interactions of human MD-2 with E . [CD14] and , together with Phe ( 126 ) , in activation of TLR4 by bound E . MD-2 . Negative_regulation CD14 UTP15 22299633 2605952 ATP and also *down-regulated* the gene expression of TLR4 , [CD14] and MyD88 ( myeloid differentiation factor 88 ) , a TLR adaptor molecule , and protein expression of CD14 and MyD88 . Negative_regulation CD14 UTP18 22299633 2605950 ATP and also *down-regulated* the gene expression of TLR4 , [CD14] and MyD88 ( myeloid differentiation factor 88 ) , a TLR adaptor molecule , and protein expression of CD14 and MyD88 . Negative_regulation CD14 UTP20 22299633 2605948 ATP and also *down-regulated* the gene expression of TLR4 , [CD14] and MyD88 ( myeloid differentiation factor 88 ) , a TLR adaptor molecule , and protein expression of CD14 and MyD88 . Negative_regulation CD14 UTP23 22299633 2605953 ATP and also *down-regulated* the gene expression of TLR4 , CD14 and MyD88 ( myeloid differentiation factor 88 ) , a TLR adaptor molecule , and protein expression of [CD14] and MyD88 . Negative_regulation CD14 UTP3 22299633 2605951 ATP and also *down-regulated* the gene expression of TLR4 , CD14 and MyD88 ( myeloid differentiation factor 88 ) , a TLR adaptor molecule , and protein expression of [CD14] and MyD88 . Negative_regulation CD14 UTP6 22299633 2605949 ATP and also *down-regulated* the gene expression of TLR4 , CD14 and MyD88 ( myeloid differentiation factor 88 ) , a TLR adaptor molecule , and protein expression of [CD14] and MyD88 . Negative_regulation CD14 ZDHHC2 8145026 252596 . gp120 significantly *reduced* the accessory function of monocytes to stimulate autologous lymphocytes with anti-CD3 , the Fc receptor mediated chemiluminescence of monocytes , and the expression of CD4 and Fc receptor I/II , while the expression of the monocyte marker [CD14] and major histocompatibility complex class I and II was not influenced . Negative_regulation CD19 CD22 17223015 1703662 CD19 regulates CD22 phosphorylation by augmenting Lyn kinase activity , while *inhibits* [CD19] phosphorylation via SHP-1 . Negative_regulation CD1A EPHB2 15810889 1392147 Conversely , the inhibition of by the specific inhibitor ( PD98059 ) , but not the p-38 inhibitor SB203580 , *restored* [CD1a] expression ( P=0.011 , n=4 ) in iC3b stimulated MDDC . Negative_regulation CD1A TNF 7536438 297250 *induced* a dose- and time dependent decrease in [CD1a+] epidermal Langerhans cell numbers and an increase in dermal CD1a+ cells , suggesting migration of Langerhans cells away from the epidermis . Negative_regulation CD1B TLR7 18253929 1871713 Stimulation with type I IFN , viral ligands or viruses strongly enhanced the number of CD1D transcripts in human myeloid DC but *diminished* the abundance of CD1A , [CD1B] and CD1E mRNA . Negative_regulation CD1D TLR7 18253929 1871723 Stimulation with type I IFN , viral ligands or viruses strongly *enhanced* the number of [CD1D] transcripts in human myeloid DC but diminished the abundance of CD1A , CD1B and CD1E mRNA . Negative_regulation CD22 BCR 16339538 1491605 By contrast , CD19/CD21 ligation using higher concentrations of SA-C3dg significantly inhibited induced [ Ca2+ ] i responses and *inhibited* CD19 , Lyn , [CD22] , and Syk phosphorylation . Negative_regulation CD22 CD19 11584010 882673 overexpression also enhanced BCR induced [ Ca ( 2+ ) ] ( i ) responses , but *down-regulated* tyrosine phosphorylation of [CD22] and multiple other cellular proteins following BCR ligation . Negative_regulation CD22 CD19 16339538 1491606 By contrast , ligation using higher concentrations of SA-C3dg significantly inhibited BCR induced [ Ca2+ ] i responses and *inhibited* CD19 , Lyn , [CD22] , and Syk phosphorylation . Negative_regulation CD22 CD79A 16339538 1491607 By contrast , CD19/CD21 ligation using higher concentrations of SA-C3dg significantly inhibited induced [ Ca2+ ] i responses and *inhibited* CD19 , Lyn , [CD22] , and Syk phosphorylation . Negative_regulation CD22 CD79B 16339538 1491608 By contrast , CD19/CD21 ligation using higher concentrations of SA-C3dg significantly inhibited induced [ Ca2+ ] i responses and *inhibited* CD19 , Lyn , [CD22] , and Syk phosphorylation . Negative_regulation CD22 CR2 16339538 1491609 By contrast , ligation using higher concentrations of SA-C3dg significantly inhibited BCR induced [ Ca2+ ] i responses and *inhibited* CD19 , Lyn , [CD22] , and Syk phosphorylation . Negative_regulation CD22 PTPN6 8627166 355810 Transient expression of CD22 and a null mutant of ( PTP-1CM ) in COS cells *resulted* in an increase in tyrosyl phosphorylation of [CD22] and its interaction with PTP-1CM . Negative_regulation CD28 FAS 9708185 526494 In Jurkat T cells , we show that signalling *leads* to rapid and selective [CD28] down-regulation , and that this is associated with a specific decrease in mRNA for CD28 , indicating that mechanisms exist which target CD28 at a transcriptional level . Negative_regulation CD28 TNF 11544310 855313 In reporter gene bioassays , was found to *inhibit* the activity of the [CD28] minimal promoter . Negative_regulation CD28 TNF 15128741 1267193 *reduced* [CD28] expression because of the inhibition of INR-driven transcription . Negative_regulation CD28 TNF 21562872 2546493 Further , Med abrogated *induced* loss of [CD28] expression in the BM T cells . Negative_regulation CD28 TNF 8095456 211926 [CD28] associated to CD3 or CD2 *induced* high levels of IL-2 , and IL-4 secretion for 10 days , in contrast to CD3 alone which induced only TNF secretion . Negative_regulation CD33 TNF 22500980 2595585 High glucose concentrations *induce* production through the down-regulation of [CD33] in primary human monocytes . Negative_regulation CD34 SELL 11239168 791807 We conclude that release of [CD34] ( + ) cells to the PB *involves* a general downregulation of Thy1 , and VLA-4 on CD34 ( + ) cells , irrespective of the growth factor used for mobilization . Negative_regulation CD34 TNF 7536684 300160 Similarly , preferentially *inhibited* total nucleated and [CD34+] cell production in the subpopulation enriched for erythroid cells . Negative_regulation CD34 TNF 9218621 442298 In HNSCC bulk cultures containing high levels of CD34+ NS activity , not only *reduced* [CD34+] cell levels , but also increased the capacity of the intratumoral T cells to express the p55 IL-2R . Negative_regulation CD36 ALOX5 19135147 2031974 This study investigated the *role* of <5-LO> in HNE induced [CD36] expression and macrophage foam cell formation , and the link between HNE and 5-LO . Negative_regulation CD36 ALOX5 19135147 2031977 In peritoneal macrophages from 5-LO-deficient mice , HNE induced CD36 expression was markedly attenuated , confirming a pivotal *role* of <5-LO> in HNE induced [CD36] expression . Negative_regulation CD36 PECAM1 9529372 496619 The down-regulation of in bEND.3 cells *resulted* in reexpression of endogenous thrombospondin-1 and its antiangiogenic receptor [CD36] . Negative_regulation CD36 TNF 17335569 1760084 We investigated the *role* of and adalimumab , a human anti-TNFalpha monoclonal antibody widely used in human pathology , in [CD36] expression in human monocytes . Negative_regulation CD36 TNF 17335569 1760087 *inhibits* both [CD36] membrane expression and mRNA expression . Negative_regulation CD36 TNF 17335569 1760088 [CD36] expression on human monocytes is *inhibited* by and independently increased by adalimumab . Negative_regulation CD36 TNF 19593846 2105354 Quantitative real-time PCR assays showed that CE treatment decreased the mRNA expression of IL-1beta , IL-6 and , improved the mRNA expression of IR , IRS1 , IRS2 , PI3K and Akt1 , *inhibited* [CD36] , MTTP , and PTEN , and enhanced the impaired SREBP-1c expression in TNF-alpha treated enterocytes . Negative_regulation CD36 TNF 24808360 2939829 In vitro , and IL-1ß significantly *inhibited* the microglia expression of [CD36] and reduced the microglia phagocytosis of RBCs . Negative_regulation CD36 TNF 7553223 323267 Removal of HLA-DR+ or [CD36+] monocytes also caused a significant reduction in S-27609- and imiquimod *induced* IFN-alpha and . Negative_regulation CD38 RNASE1 8877402 390524 BS significantly *inhibited* the expression of CD25 , [CD38] and CD71 antigens on PHA- , Con A- and MLC stimulated human T and B lymphocytes . Negative_regulation CD38 RNASE7 8877402 390532 BS significantly *inhibited* the expression of CD25 , [CD38] and CD71 antigens on PHA- , Con A- and MLC stimulated human T and B lymphocytes . Negative_regulation CD3D JAG1 8757315 377707 CD4 participation in TCR/CD3 associated activation through interaction with the MHC class II *results* in formation of a [CD4-TCR/CD3] complex capable of maximal signal transduction . Negative_regulation CD3E JAG1 8757315 377708 CD4 participation in TCR/CD3 associated activation through interaction with the MHC class II *results* in formation of a [CD4-TCR/CD3] complex capable of maximal signal transduction . Negative_regulation CD3EAP CAPN8 22206846 2575097 In summary , in vivo *inhibition* mediated by [CAST] transgene expression reduces Aß pathology in APP23 mice , with our findings further suggesting that APP metabolism is modified by CAST overexpression as the mice develop Aß pathology . Negative_regulation CD3G JAG1 8757315 377709 CD4 participation in TCR/CD3 associated activation through interaction with the MHC class II *results* in formation of a [CD4-TCR/CD3] complex capable of maximal signal transduction . Negative_regulation CD4 CD14 24598451 2925052 Cocultures showed that ascites ( + ) cells markedly *suppressed* antigen-specific [CD4] ( + ) T responses , but suppression could be alleviated by treatment with anti-IL-10 or inhibition of indoleamine 2,3-dioxygenase . Negative_regulation CD4 FAS 10196277 604631 Antiretroviral cytolytic T-lymphocyte nonresponsiveness : *mediated* inhibition of [CD4] ( + ) and CD8 ( + ) antiviral T cells by viral antigen positive veto cells . Negative_regulation CD4 FAS 15322178 1286789 Our results reveal an important *dependent* mechanism for the regulation of hapten-specific [CD4] ( + ) T cell responses by CD8 ( + ) T cells , which causes the dominance of CD8 ( + ) effector T cells and the active suppression of a CD4 ( + ) T cell response . Negative_regulation CD4 FAS 23943615 2845262 ligation could promote regulatory DCs to *inhibit* [CD4] ( + ) T cell proliferation more significantly . Negative_regulation CD4 FAS 8924258 371605 To analyse the *role* of the apoptosis inducing receptor in the depletion of [CD4+] and CD8+ T cells in HIV infected individuals . Negative_regulation CD4 IL1R2 17182252 1688330 gene transfer *reduced* intragraft monocytes/macrophages and [CD4] ( + ) cell infiltrates ( p < 0.05 ) , TNF-alpha and transforming growth factor-beta ( TGF-beta ) expression ( p < 0.05 ) , and prolonged graft survival ( 15.6+/-5.7 vs 10.3+/-2.5 days with control vector and 10.1+/-2.1 days with buffer alone ; p < 0.01 ) . Negative_regulation CD4 ITGAL 15778396 1385097 These results indicate a prominent *role* for HLA-DP and in BAL [CD4] ( + ) T cell activation and further suggest that specific Abs to these molecules could serve as a possible therapy for chronic beryllium disease . Negative_regulation CD4 ITGB2 15383575 1298949 We examined the *role* of in [CD4] ( + ) T cell activation in vivo by using a system that allows for segregation of the migration and activation defects through the adoptive transfer of LFA-1-deficient ( CD18 ( -/- ) ) CD4 ( + ) T cells from DO11.10 Ag-specific TCR transgenic mice into wild-type BALB/c mice . Negative_regulation CD4 JAG1 8757315 377710 CD4 participation in TCR/CD3 associated activation through interaction with the MHC class II *results* in formation of a [CD4-TCR/CD3] complex capable of maximal signal transduction . Negative_regulation CD4 LBP 16159572 1455956 could significantly *increase* the numbers of [CD4] ( + ) and CD8 ( + ) T cells in TIL as compared with those in model control group ( P < 0.05 ) . Negative_regulation CD4 TNF 15749890 1379716 In the absence of WSX-1 , an increased production of the proinflammatory cytokines and IL-12p40 *resulted* in elevated [CD4+] T cell activation and IFN-gamma production , which enhanced macrophage effector functions and reduced bacterial loads . Negative_regulation CD4 TNF 19595251 2105474 The level of decreased , and the numbers of CD ( 3 ) ( + ) and [CD(4)] ( + ) T lymphocytes *increased* significantly on day 4 in Combined Therapy Group ( P < 0.05 or P < 0.01 ) . Negative_regulation CD4 TNFSF10 15884050 1426468 Additionally , the inhibition of IL-2 dependent [CD4] ( + ) or CD8 ( + ) T cell blast growth upon CD3 or CD59 ligation was *dependent* , at least partially , on FasL and/or . Negative_regulation CD40 CD22 16393971 1505963 By contrast , anti-CD40 stimulation specifically up-regulated anti-IgM induced phosphorylation of tyrosines within two ITIM motifs , Y762 and Y842 , which was consistent with in vivo finding of the negative *role* of in [CD40] signaling . Negative_regulation CD40 IL1B 11971025 933516 It prevented NF-kappa B binding to the COX-2 promoter through a new pathway that is the *repression* of NF-kappa [Bp50] induction by . Negative_regulation CD40 IL1B 15696085 1372141 alone had no effect , but it *attenuated* the TNF induced expression of both [CD40] and OX40 ligand . Negative_regulation CD40 MMP28 20921282 2337458 Furthermore , [IL-2/a-CD40] *induced* the IFN-?- and NO-dependent decrease in expression and activity , concomitant with increases in tissue inhibitor of metalloproteinase ( TIMP ) 1 and E-cadherin expression within tumors . Negative_regulation CD40 MMP7 20921282 2337473 Furthermore , [IL-2/a-CD40] *induced* the IFN-?- and NO-dependent decrease in expression and activity , concomitant with increases in tissue inhibitor of metalloproteinase ( TIMP ) 1 and E-cadherin expression within tumors . Negative_regulation CD40 TLR7 22685319 2675981 Interestingly , despite expression of TLR mRNA on Kupffer cells , ligation of TLR4 , , and TLR9 *resulted* in a weak induction of IL-10 , low or undetectable levels of IL-12p40 and TNF , and up-regulation of [CD40] on the surface . Negative_regulation CD40 TNF 10332965 614903 IL-10 exerted inhibitory effects on both [CD40] ligation induced and CD40 ligation plus IFN-gamma *induced* production by ST cells . Negative_regulation CD40 TNF 10594746 573125 Furthermore , *restored* the DEX induced inhibition of [CD40] expression on Langerhans cells , but not the inhibition of B7-1 or B7-2 expression . Negative_regulation CD40 TNF 11830590 928972 Critical *role* of and NF-kappa B in interferon-gamma -induced [CD40] expression in microglia/macrophages . Negative_regulation CD40 TNF 15578092 1344758 We found that induced OX40 expression on T cells and *blocking* the interaction between either [CD40] and its ligand or OX40 and its ligand suppressed development of arthritis . Negative_regulation CD40 TNF 20006573 2199871 Thus , *mediated* regulation of [CD40] expression occurs by dual phosphorylation of SMAR1 and STAT1 . Negative_regulation CD40 TNF 22010829 2539712 These results reveal an important *role* of induction in [CD40] 's chemosensitization activity and suggest that modulating TNF-a autocrine from cancer cells is an effective option for increasing the anticancer value of chemotherapeutics such as cisplatin . Negative_regulation CD40 TNF 22956783 2684022 Abundance of miR-181a attenuated ox-LDL induced CD83 and [CD40] expression , *inhibited* the secretion of interleukin (IL)-6 and , and up-regulated IL-10 , an important anti-inflammatory cytokine that was inhibited by ox-LDL . Negative_regulation CD40 TNF 23075766 2710533 *reduced* SIRT1 expression and induced [CD40] expression in CRL-1730 endothelial cells in a time- and concentration- dependent manner . Negative_regulation CD40LG ARSA 14730251 1198937 In healthy volunteers , [CD40L] expression in platelets is not significantly *inhibited* by alone , but is inhibited after treatment with the ADP-receptor antagonist clopidogrel or with clopidogrel plus ASA . Negative_regulation CD40LG EPHB2 22142890 2568508 Decreased activation also *resulted* in overexpression and demethylation of the X-linked methylation-sensitive gene [CD40lg] in female but not male mice , consistent with demethylation of the second X chromosome in the females . Negative_regulation CD44 FAS 16555058 1604172 The TM-TNFalpha expressing tumors up-regulated ( CD95 ) expression and *inhibited* the expression of tumor metastasis associated molecule [CD44v3] . Negative_regulation CD44 IL1B 10547196 564714 Both IL-1alpha and *reduced* [CD44] membrane expression of MIA PaCa 2 , while TGF-beta1 increased the percentage of CD44 positive CAPAN-1 cells . Negative_regulation CD44 IL1B 18427719 1920731 The present study clearly suggests that HA binds [CD44] and *inhibits* induced MMP-1 and -13 expression via down-regulation of Phos-p38 in SW-1353 cells . Negative_regulation CD44 IL1B 9197378 438541 In addition , pretreatment of infected monocytes with a TNF-alpha synthesis inhibitor , RP 55778 , or with MAbs directed against IL-1beta , confirmed the *role* of TNF-alpha and in the regulation of CD18 , [CD44] , and CD54 expression . Negative_regulation CD44 TNF 12867430 1141917 Blocking production by PD98059 , a p42/44 inhibitor , significantly *reduced* the LPS induced sialidase activity and [CD44-HA] binding . Negative_regulation CD44 TNF 16555058 1604171 The expressing tumors up-regulated Fas ( CD95 ) expression and *inhibited* the expression of tumor metastasis associated molecule [CD44v3] . Negative_regulation CD44 TNF 16908592 1601620 However , little is known about the *role* of in [CD44] expression of cancer cells . Negative_regulation CD44 TNF 22386367 2572488 We found that *down-regulated* [CD44s] expression , up-regulated CD44v3 and CD44v6 expression through JNK pathway in MCF-7 cells . Negative_regulation CD44 TNF 9197378 438540 In addition , pretreatment of infected monocytes with a TNF-alpha synthesis inhibitor , RP 55778 , or with MAbs directed against IL-1beta , confirmed the *role* of and IL-1beta in the regulation of CD18 , [CD44] , and CD54 expression . Negative_regulation CD47 IL1B 17233117 1664220 We conclude that and TNF-alpha *inhibit* NaBu induced [IAP] gene expression , likely by blocking the histone acetylation within its promoter . Negative_regulation CD47 TNF 17233117 1664219 We conclude that IL-1beta and *inhibit* NaBu induced [IAP] gene expression , likely by blocking the histone acetylation within its promoter . Negative_regulation CD47 TNFSF10 15385934 1324170 *induced* no discernible changes in FLIP , DR4 , DR5 , Mcl-1 , or survivin expression , modest declines in levels of DcR2 and [c-IAP] , but resulted in the marked transcriptional downregulation of XIAP . Negative_regulation CD58 SELL 8449611 214010 CD2 , CD44 , CD54 and [CD58] were *increased* by IL-2 but was strongly down-regulated on the long-term activated NK cells . Negative_regulation CD59 TNF 10480555 643522 Northern blot analysis showed that the mRNA expression of C3 , C4 , DAF and Crry was up-regulated , but that of [CD59] was *down-regulated* by IFN-gamma , and/or LPS alone or by synergy . Negative_regulation CD69 ALOX5 11200053 779711 Pivotal role of <5-lipoxygenase> in the activation of human eosinophils : platelet activating factor and interleukin-5 *induce* [CD69] on eosinophils through the 5-lipoxygenase pathway . Negative_regulation CD79A CD22 23456653 2760567 Epratuzumab is a humanized monoclonal antibody that targets CD22 on B cells and results in modulation of B-cell function and migration , as regulates adhesion and *inhibits* [B-cell receptor (BCR)] signalling . Negative_regulation CD79A CTGF 15012739 1183020 The present study was designed to elucidate the *role* of in diabetic nephropathy (DN) , [immunoglobulin A nephropathy (IgA-N)] , membranous nephropathy ( MN ) , and minimal change nephrotic syndrome ( MCNS ) . Negative_regulation CD79A NES 8132219 251467 *inhibited* IgM and [IgA1] production from human lymphoblastoid B-cell lines CBL and GM-1056 , respectively , in a dose dependent fashion . Negative_regulation CD79A NES 8132219 251468 also *inhibited* production of IgM , IgG1 , IgG2 , IgG3 , IgG4 , [IgA1] and IgA2 by tonsillar B cells stimulated with Staphylococcus aureus Cowan strain I ( SAC ) and IL-6 without affecting proliferation . Negative_regulation CD79A TNF 9338552 458421 In vitro observations showed that exogenously added and TNF-beta *inhibited* IgG and [IgA] secretion by pokeweed mitogen stimulated mononuclear cells . Negative_regulation CD79A TNF 9338552 458423 These results suggest that may be *involved* in the regulation of IgG and [IgA] production and can be associated with an arrest of IgG and IgA switch of B cells in hypogammaglobulinemia . Negative_regulation CD79B CD22 23456653 2760568 Epratuzumab is a humanized monoclonal antibody that targets CD22 on B cells and results in modulation of B-cell function and migration , as regulates adhesion and *inhibits* [B-cell receptor (BCR)] signalling . Negative_regulation CD80 TNF 10594746 573126 Furthermore , *restored* the DEX induced inhibition of CD40 expression on Langerhans cells , but not the inhibition of [B7-1] or B7-2 expression . Negative_regulation CD80 TNF 19278729 2063553 Stimulation with , S. gordonii , PGN , LTA , or LP all *resulted* in increased surface expression of MHCII , [CD80] , and CD86 , compared to unstimulated BM-DCs . Negative_regulation CD80 TNF 23000301 2694267 We found that Tregs derived from the tumor mice down-regulated the expression of costimulatory molecules [CD80/CD86] on DCs and *inhibited* the production of and IL-12 from DCs . Negative_regulation CD81 EPHB2 14676841 1211196 In addition , overexpression of [CD81] in HepG2 cells , NIH3T3 cells , and murine fibroblasts GD25 lacking the beta1 family of integrins *induces* cell proliferation and activation . Negative_regulation CD81 PCSK9 19489072 2102867 Interestingly , stable expression of or a more active membrane bound form of the protein ( PCSK9-ACE2 ) *resulted* in a marked reduction in [CD81] and LDLR expression . Negative_regulation CD82 MAP2K6 16157583 1475807 Pharmacologic inhibitors of protein kinase C , Ras , and , but not phosphoinositide 3-kinase , *block* [ST6Gal-I] down-regulation , integrin hyposialylation , and fibronectin binding . Negative_regulation CD83 TNF 22956783 2684025 Abundance of miR-181a attenuated ox-LDL induced [CD83] and CD40 expression , *inhibited* the secretion of interleukin (IL)-6 and , and up-regulated IL-10 , an important anti-inflammatory cytokine that was inhibited by ox-LDL . Negative_regulation CD86 ADRB2 12055247 951799 B cell receptor- and *induced* regulation of [B7-2] ( CD86 ) expression in B cells . Negative_regulation CD86 IL1B 9394834 468234 In addition , the up-regulation of [CD86] expression on DC treated with DNCB was significantly *suppressed* by either or anti-TNF-alpha antibody , while that by NiCl2 was relatively insensitive to these antibody treatments . Negative_regulation CD86 TF 11509640 848647 Lactoferrin and lactoferricin B , but not , *inhibited* CpG ODN stimulation of [CD86] expression in the human Ramos B cell line and decreased cellular uptake of ODN , a process required for CpG bioactivity . Negative_regulation CD86 TNF 10594746 573127 Furthermore , *restored* the DEX induced inhibition of CD40 expression on Langerhans cells , but not the inhibition of B7-1 or [B7-2] expression . Negative_regulation CD86 TNF 19278729 2063555 Stimulation with , S. gordonii , PGN , LTA , or LP all *resulted* in increased surface expression of MHCII , CD80 , and [CD86] , compared to unstimulated BM-DCs . Negative_regulation CD86 TNF 23000301 2694270 We found that Tregs derived from the tumor mice down-regulated the expression of costimulatory molecules [CD80/CD86] on DCs and *inhibited* the production of and IL-12 from DCs . Negative_regulation CD86 TNF 8647204 366286 , which elicits both Th1- and Th2 characteristics depending on experimental conditions , *down-regulated* [B7-2] but did not alter B7-1 expression . Negative_regulation CD8A FAS 10196277 604633 Antiretroviral cytolytic T-lymphocyte nonresponsiveness : *mediated* inhibition of CD4 ( + ) and [CD8] ( + ) antiviral T cells by viral antigen positive veto cells . Negative_regulation CD8A FAS 8892953 392263 Thus , is not *required* for the immune downregulation of the [CD8+-T-lymphocyte] response following acute LCMV infection . Negative_regulation CD8A FOXO1 22425248 2573073 Transcription factor *represses* T-bet mediated effector functions and promotes memory [CD8] ( + ) T cell differentiation . Negative_regulation CD8A IFI27 20200542 2265346 However , silencing of Foxp3 reduced expression of Foxp3 , and PD1-all of which are *involved* in the suppressive capacity of [CD8] ( + ) Treg in this model . Negative_regulation CD8A IFI27 21326316 2453084 Our findings indicate a potential *role* for in the suppressive capacity of peptide induced regulatory [CD8] ( + ) Ti cells through effects on the expression of Foxp3 and the synthesis of TGFß . Negative_regulation CD8A ITGAL 24158516 2889567 Essential *role* of in [CD8+] T-cell accumulation and activation in adipose tissue . Negative_regulation CD8A JAG1 19265135 2045492 Injection of OVA and Jagged1 encoding plasmids inhibited proliferation of OVA-specific granzyme B-producing CD8 ( + ) T cells , although could not directly *inhibit* [CD8] ( + ) T cell proliferation in vitro . Negative_regulation CD8A JAG1 19535638 2098917 characterizing tumors or chronic viral infection are generally presented to the host immune system before specific immunotherapy is initiated , and consequent generation of regulatory CD4 ( + ) T cells can *inhibit* induction of desired effector [CD8] T cell responses . Negative_regulation CD8A JAG1 20729328 2313175 We further demonstrated that delivering to DCs via hDectin-1 using anti-hDectin-1-Ag conjugates *resulted* in potent Ag-specific [CD8] ( + ) T cell responses . Negative_regulation CD8A LBP 16159572 1455957 could significantly *increase* the numbers of CD4 ( + ) and [CD8] ( + ) T cells in TIL as compared with those in model control group ( P < 0.05 ) . Negative_regulation CD8A OASL 23874199 2817742 deficiency also *led* to the accelerated elimination of viremia and induction of a functional antiviral [CD8] T-cell response , which critically depended on IFN-I receptor signaling . Negative_regulation CD8A TNF 15596816 1356615 *Role* of receptors in regulating [CD8] T-cell responses during acute lymphocytic choriomeningitis virus infection . Negative_regulation CD8A TNF 15596816 1356617 To address these issues , we have investigated the *role* of I ( p55R ) and II ( p75R ) in regulating [CD8] T-cell responses to lymphocytic choriomeningitis virus ( LCMV ) with wild-type , p55R-deficient ( p55 ( -/- ) ) , p75R-deficient ( p75 ( -/- ) ) , and p55R- and p75R-deficient ( DKO ) mice . Negative_regulation CD8A TNF 18439426 1920983 Furthermore , [CD8alphabeta] lymphocyte recruitment in the intestinal epithelium and inflammatory infiltration in the LP are not *impaired* in CCR9- or CCL25-deficient ( DeltaARE ) mice . Negative_regulation CD8A TNFSF10 15884050 1426470 Additionally , the inhibition of IL-2 dependent CD4 ( + ) or [CD8] ( + ) T cell blast growth upon CD3 or CD59 ligation was *dependent* , at least partially , on FasL and/or . Negative_regulation CD8A TNFSF10 17127445 1667937 However , a *role* of as a fine tuning regulator of the immune system , especially in the regulation of [CD8+] T cell activation and memory , has been also demonstrated . Negative_regulation CD8A TNFSF10 21940678 2497479 The current study examined the *role* of in the pulmonary [CD8] T cell response to a clinically significant IAV [ A/PR/8/34 ( PR8 ; Negative_regulation CD8B FOXO1 22425248 2573074 Transcription factor *represses* T-bet mediated effector functions and promotes memory [CD8] ( + ) T cell differentiation . Negative_regulation CD8B IFI27 21326316 2453090 Our findings indicate a potential *role* for in the suppressive capacity of peptide induced regulatory [CD8] ( + ) Ti cells through effects on the expression of Foxp3 and the synthesis of TGFß . Negative_regulation CD8B JAG1 19535638 2098919 characterizing tumors or chronic viral infection are generally presented to the host immune system before specific immunotherapy is initiated , and consequent generation of regulatory CD4 ( + ) T cells can *inhibit* induction of desired effector [CD8] T cell responses . Negative_regulation CD8B JAG1 20729328 2313176 We further demonstrated that delivering to DCs via hDectin-1 using anti-hDectin-1-Ag conjugates *resulted* in potent Ag-specific [CD8] ( + ) T cell responses . Negative_regulation CD8B LBP 16159572 1455958 could significantly *increase* the numbers of CD4 ( + ) and [CD8] ( + ) T cells in TIL as compared with those in model control group ( P < 0.05 ) . Negative_regulation CD8B TNF 18439426 1920985 Furthermore , [CD8alphabeta] lymphocyte recruitment in the intestinal epithelium and inflammatory infiltration in the LP are not *impaired* in CCR9- or CCL25-deficient ( DeltaARE ) mice . Negative_regulation CD8B TNFSF10 15884050 1426472 Additionally , the inhibition of IL-2 dependent CD4 ( + ) or [CD8] ( + ) T cell blast growth upon CD3 or CD59 ligation was *dependent* , at least partially , on FasL and/or . Negative_regulation CD8B TNFSF10 17127445 1667938 However , a *role* of as a fine tuning regulator of the immune system , especially in the regulation of [CD8+] T cell activation and memory , has been also demonstrated . Negative_regulation CD9 TCN1 7685612 219776 and TCN-P markedly *inhibited* HIV-1 induced [p24] core antigen production , reverse transcriptase , and infectious virus production in a dose dependent manner using HIV-1 acutely infected CEM-SS , H9 , and persistently infected H9IIIB and U1 cells . Negative_regulation CDC123 SLC6A2 10219244 609084 From G1 through anaphase , RENT localizes to the nucleolus , and [Cdc14] activity is *inhibited* by . Negative_regulation CDC123 SLC6A2 12056824 951968 Cdc14 sequestered in the nucleolus by forming a complex with , a nucleolar *inhibitor* of [Cdc14] , is activated after the release from the nucleolus and Cdc5 is essential for this release . Negative_regulation CDC123 SLC6A2 12598903 1064388 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Negative_regulation CDC16 SLC6A2 10219244 609085 From G1 through anaphase , RENT localizes to the nucleolus , and [Cdc14] activity is *inhibited* by . Negative_regulation CDC16 SLC6A2 12056824 951969 Cdc14 sequestered in the nucleolus by forming a complex with , a nucleolar *inhibitor* of [Cdc14] , is activated after the release from the nucleolus and Cdc5 is essential for this release . Negative_regulation CDC16 SLC6A2 12598903 1064389 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Negative_regulation CDC16 TFPI2 9405394 469794 The direct interaction of PP5 with CDC16 and CDC27 , as well as its overlapping spindle localization in mitosis , suggests that may be *involved* in the regulation of the activity of the [anaphase promoting complex] . Negative_regulation CDC20 ID1 18372912 1938165 The negative effect of on APC ( Cdh1 ) *results* in suppression of APC ( Cdh1 ) -induced Aurora A and [Cdc20] degradation , leading to failure in cytokinesis . Negative_regulation CDC20 SLC6A2 10219244 609086 From G1 through anaphase , RENT localizes to the nucleolus , and [Cdc14] activity is *inhibited* by . Negative_regulation CDC20 SLC6A2 12056824 951970 Cdc14 sequestered in the nucleolus by forming a complex with , a nucleolar *inhibitor* of [Cdc14] , is activated after the release from the nucleolus and Cdc5 is essential for this release . Negative_regulation CDC20 SLC6A2 12598903 1064390 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Negative_regulation CDC20 TNF 22025632 2508064 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation CDC23 SLC6A2 10219244 609087 From G1 through anaphase , RENT localizes to the nucleolus , and [Cdc14] activity is *inhibited* by . Negative_regulation CDC23 SLC6A2 12056824 951971 Cdc14 sequestered in the nucleolus by forming a complex with , a nucleolar *inhibitor* of [Cdc14] , is activated after the release from the nucleolus and Cdc5 is essential for this release . Negative_regulation CDC23 SLC6A2 12598903 1064391 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Negative_regulation CDC23 TFPI2 9405394 469795 The direct interaction of PP5 with CDC16 and CDC27 , as well as its overlapping spindle localization in mitosis , suggests that may be *involved* in the regulation of the activity of the [anaphase promoting complex] . Negative_regulation CDC25A EPHB2 15672448 1409534 Cdc25A and interaction : EGFR independent ERK *activation* by a protein phosphatase [Cdc25A] inhibitor , compound 5 . Negative_regulation CDC25A TP63 17001315 1708812 In contrast to p53 , neither nor p73 can *repress* [Cdc25A] transcription . Negative_regulation CDC25C NES 11313932 805951 However , complete nuclear accumulation of [Cdc25C] *required* loss of both function and 14-3-3 binding and this was accomplished both pharmacologically and by mutation . Negative_regulation CDC26 SLC6A2 10219244 609096 From G1 through anaphase , RENT localizes to the nucleolus , and [Cdc14] activity is *inhibited* by . Negative_regulation CDC26 SLC6A2 12056824 951980 Cdc14 sequestered in the nucleolus by forming a complex with , a nucleolar *inhibitor* of [Cdc14] , is activated after the release from the nucleolus and Cdc5 is essential for this release . Negative_regulation CDC26 SLC6A2 12598903 1064400 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Negative_regulation CDC27 SLC6A2 10219244 609088 From G1 through anaphase , RENT localizes to the nucleolus , and [Cdc14] activity is *inhibited* by . Negative_regulation CDC27 SLC6A2 12056824 951972 Cdc14 sequestered in the nucleolus by forming a complex with , a nucleolar *inhibitor* of [Cdc14] , is activated after the release from the nucleolus and Cdc5 is essential for this release . Negative_regulation CDC27 SLC6A2 12598903 1064392 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Negative_regulation CDC27 TFPI2 9405394 469796 The direct interaction of PP5 with CDC16 and CDC27 , as well as its overlapping spindle localization in mitosis , suggests that may be *involved* in the regulation of the activity of the [anaphase promoting complex] . Negative_regulation CDC34 SLC6A2 10219244 609089 From G1 through anaphase , RENT localizes to the nucleolus , and [Cdc14] activity is *inhibited* by . Negative_regulation CDC34 SLC6A2 12056824 951973 Cdc14 sequestered in the nucleolus by forming a complex with , a nucleolar *inhibitor* of [Cdc14] , is activated after the release from the nucleolus and Cdc5 is essential for this release . Negative_regulation CDC34 SLC6A2 12598903 1064393 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Negative_regulation CDC37 SLC6A2 10219244 609090 From G1 through anaphase , RENT localizes to the nucleolus , and [Cdc14] activity is *inhibited* by . Negative_regulation CDC37 SLC6A2 12056824 951974 Cdc14 sequestered in the nucleolus by forming a complex with , a nucleolar *inhibitor* of [Cdc14] , is activated after the release from the nucleolus and Cdc5 is essential for this release . Negative_regulation CDC37 SLC6A2 12598903 1064394 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Negative_regulation CDC40 SLC6A2 10219244 609091 From G1 through anaphase , RENT localizes to the nucleolus , and [Cdc14] activity is *inhibited* by . Negative_regulation CDC40 SLC6A2 12056824 951975 Cdc14 sequestered in the nucleolus by forming a complex with , a nucleolar *inhibitor* of [Cdc14] , is activated after the release from the nucleolus and Cdc5 is essential for this release . Negative_regulation CDC40 SLC6A2 12598903 1064395 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Negative_regulation CDC42 CAPN8 12649322 1072351 Further , both inhibition and stimulation with IL-8 and formyl-Met-Leu-Phe ( fMLP ) *induced* an increase in [Cdc42] and Rac activation . Negative_regulation CDC42 MAP2K6 20869211 2337202 Moreover , overexpression of ultimately *led* to the upregulation of [Cdc42] and Rac1 , suggesting that MKK6 acts as a crucial upstream signaling molecule for Rho family GTPases . Negative_regulation CDC42 SLC6A2 10219244 609092 From G1 through anaphase , RENT localizes to the nucleolus , and [Cdc14] activity is *inhibited* by . Negative_regulation CDC42 SLC6A2 12056824 951976 Cdc14 sequestered in the nucleolus by forming a complex with , a nucleolar *inhibitor* of [Cdc14] , is activated after the release from the nucleolus and Cdc5 is essential for this release . Negative_regulation CDC42 SLC6A2 12598903 1064396 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Negative_regulation CDC42EP5 CDC42 11584266 865947 negatively regulates this effect and *inhibits* the binding of [Borg3] to septins . Negative_regulation CDC45 SLC6A2 10219244 609093 From G1 through anaphase , RENT localizes to the nucleolus , and [Cdc14] activity is *inhibited* by . Negative_regulation CDC45 SLC6A2 12056824 951977 Cdc14 sequestered in the nucleolus by forming a complex with , a nucleolar *inhibitor* of [Cdc14] , is activated after the release from the nucleolus and Cdc5 is essential for this release . Negative_regulation CDC45 SLC6A2 12598903 1064397 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Negative_regulation CDC6 SLC6A2 10219244 609094 From G1 through anaphase , RENT localizes to the nucleolus , and [Cdc14] activity is *inhibited* by . Negative_regulation CDC6 SLC6A2 12056824 951978 Cdc14 sequestered in the nucleolus by forming a complex with , a nucleolar *inhibitor* of [Cdc14] , is activated after the release from the nucleolus and Cdc5 is essential for this release . Negative_regulation CDC6 SLC6A2 12598903 1064398 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Negative_regulation CDC7 SLC6A2 10219244 609095 From G1 through anaphase , RENT localizes to the nucleolus , and [Cdc14] activity is *inhibited* by . Negative_regulation CDC7 SLC6A2 12056824 951979 Cdc14 sequestered in the nucleolus by forming a complex with , a nucleolar *inhibitor* of [Cdc14] , is activated after the release from the nucleolus and Cdc5 is essential for this release . Negative_regulation CDC7 SLC6A2 12598903 1064399 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Negative_regulation CDC7 STK39 24900258 2523207 A ligand based 3D pharmacophore model for [CDC7] *inhibition* was created and successfully applied in the discovery of novel 2- ( heteroaryl ) -6,7-dihydrothieno [ 3,2-c ] pyridin-4 ( 5H ) -ones . Negative_regulation CDC73 ARSA 6711391 37373 These studies suggest that regulates PAF availability unrelated to its effect on cyclooxygenase and that MC membrane products directly *inhibit* [PAF] activity from rat PLC . Negative_regulation CDC73 ARSA 8430224 212739 Since acetylsalicylic acid (ASA) is an accepted therapeutic alternative in these patients , we sought to determine if would *attenuate* endothelial cell [PAF] production resulting from ACA exposure . Negative_regulation CDC73 CD14 7541418 310475 The soluble form of ( sCD14 ) , when added to MO stimulated with LBP-LPS complexes , *inhibited* the synthesis of [PAF] possibly by competing with mCD14 . Negative_regulation CDC73 IL1B 1519663 196898 Stimulation of isolated mouse alveolar macrophages with recombinant murine or IL-1 alpha *resulted* in rapid , dose dependent , and cell concentration dependent increases in [PAF] secretion . Negative_regulation CDC73 SLC6A2 10219244 609083 From G1 through anaphase , RENT localizes to the nucleolus , and [Cdc14] activity is *inhibited* by . Negative_regulation CDC73 SLC6A2 12056824 951967 Cdc14 sequestered in the nucleolus by forming a complex with , a nucleolar *inhibitor* of [Cdc14] , is activated after the release from the nucleolus and Cdc5 is essential for this release . Negative_regulation CDC73 SLC6A2 12598903 1064387 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Negative_regulation CDC73 TNF 9403541 469608 Furthermore , inhibiting [PAF] production with AACOCF3 , or manoalide , also *inhibited* LPS induced Mphi mRNA expression . Negative_regulation CDCA2 HSD11B2 8969942 402762 These results show that both 3 alpha,5B-THP and [CDCA] are hypertensinogenic in the rat and that the inhibition of either <11 beta-HSD2> or 11 beta-HSD1 activity by endogenous progesterone metabolites and CDCA may be *involved* in the pathology of hypertension . Negative_regulation CDCA3 HSD11B2 8969942 402763 These results show that both 3 alpha,5B-THP and [CDCA] are hypertensinogenic in the rat and that the inhibition of either 11 beta-HSD2 or <11 beta-HSD1> activity by endogenous progesterone metabolites and CDCA may be *involved* in the pathology of hypertension . Negative_regulation CDCA4 HSD11B2 8969942 402764 These results show that both 3 alpha,5B-THP and [CDCA] are hypertensinogenic in the rat and that the inhibition of either <11 beta-HSD2> or 11 beta-HSD1 activity by endogenous progesterone metabolites and CDCA may be *involved* in the pathology of hypertension . Negative_regulation CDCA5 FAS 10754300 682552 [p35] expression *inhibited* ( CD95 ) - , CD3- , or peptide induced caspase activity in vitro and conferred resistance to Fas induced apoptosis . Negative_regulation CDCA5 HSD11B2 8969942 402765 These results show that both 3 alpha,5B-THP and [CDCA] are hypertensinogenic in the rat and that the inhibition of either 11 beta-HSD2 or <11 beta-HSD1> activity by endogenous progesterone metabolites and CDCA may be *involved* in the pathology of hypertension . Negative_regulation CDCA7 HSD11B2 8969942 402766 These results show that both 3 alpha,5B-THP and [CDCA] are hypertensinogenic in the rat and that the inhibition of either <11 beta-HSD2> or 11 beta-HSD1 activity by endogenous progesterone metabolites and CDCA may be *involved* in the pathology of hypertension . Negative_regulation CDCA8 HSD11B2 8969942 402767 These results show that both 3 alpha,5B-THP and [CDCA] are hypertensinogenic in the rat and that the inhibition of either 11 beta-HSD2 or <11 beta-HSD1> activity by endogenous progesterone metabolites and CDCA may be *involved* in the pathology of hypertension . Negative_regulation CDH1 CAPN8 12393869 1035833 The *role* of in the proteolytic cleavage of [E-cadherin] in prostate and mammary epithelial cells . Negative_regulation CDH1 CAPN8 21825064 2485373 H. pylori induced activation *results* in cleavage of [E-cadherin] to produce a 100-kDa truncated form and induce relocalization of E-cadherin and ß-catenin . Negative_regulation CDH1 CCND1 18187454 1856835 E-cadherin mediated cell-cell adhesion also supports induction in these cells , and the combined inhibition of both [E-cadherin] and integrin adhesion is *required* to prevent the expression of cyclin D1 mRNA and protein . Negative_regulation CDH1 CHI3L1 21991364 2493509 also *suppressed* expression of [E-cadherin] but increased MMP-9 and cell motility , the crucial mechanisms that mediate mammary tissue remodeling during involution . Negative_regulation CDH1 EPHB2 20824291 2341832 Inhibition of signaling *mediated* up-regulation of [E-cadherin] and claudin-4 , and/or decreased expression of matrix metalloproteinases ( MMPs ) such as MMP-2 and MMP-9 , play a role in the TZD induced inhibition of cancer cell invasion . Negative_regulation CDH1 EPHB2 21181094 2385809 uPA/ uPAR downregulation also induces [E-cadherin] expression and *inhibits* activation of . Negative_regulation CDH1 EPHB2 23554977 2767288 The pharmacological inhibition of phosphatidylinositol-3-kinase (PI3K) , mammalian target of rapamycin (mTOR) , and MEK suggests that both PI3K/Akt/mTOR and signaling are *required* for FGF2 induced [E-cadherin] down-regulation . Negative_regulation CDH1 F2R 24378645 2917261 The epithelial inhibition by SCH-79797 *restored* [E-cadherin] induction and deterred a-SMA induction , indicating that epithelial PAR-1 localization was responsible for resulting in airway EMT . Negative_regulation CDH1 FAS 23929433 2887884 Inhibition of signaling by downregulation of the Fas receptor *led* to a decrease in miR-23a expression and cell invasion ability in vivo and in vitro , as well as an increase in [E-cadherin] . Negative_regulation CDH1 FOXA1 22590586 2598957 Knockdown of FOXA1 in RT4 bladder cancer cells resulted in increased expression of UPK1B , UPK2 , UPK3A , and UPK3B , decreased E-cadherin expression and significantly increased cell proliferation , while overexpression of in T24 cells *increased* [E-cadherin] expression and significantly decreased cell growth and invasion . Negative_regulation CDH1 FOXQ1 21285253 2393079 Notably , *repressed* expression of the core EMT regulator [E-cadherin] by binding to the E-box in its promoter region . Negative_regulation CDH1 HBEGF 12057867 952229 In contrast , epidermal growth factor (EGF) or ( HB-EGF ) *induces* the epithelial-like to fibroblastoid conversion of A549 and H322 cell lines , slightly reduces the expression of [E-cadherin] and beta-catenin , but not alpha- and gamma-catenins , and stimulates cell motility . Negative_regulation CDH1 HBEGF 17875687 1796183 Our data here clearly indicated the distinct *role* of in the regulation of [E-cadherin] expression and the epithelial-mesenchymal transition . Negative_regulation CDH1 HBEGF 17875687 1796186 Expression of noncleaved in pancreatic cells *resulted* in the up-regulation of [E-cadherin] through suppression of ZEB1 , which is a transcriptional repressor of E-cadherin . Negative_regulation CDH1 ID1 16007183 1459362 Ectopic overexpression of was not *sufficient* to induce [E-cadherin] , which was critical for the morphological changes induced by 1alpha,25 ( OH ) 2D3 in SW480-ADH cells . Negative_regulation CDH1 ID1 17202424 1688832 Ectopic expression of *suppressed* epithelial [E-cadherin] and zonula occludens-1 expression . Negative_regulation CDH1 JAG1 17984306 1826745 mediated Notch activation *induces* epithelial-to-mesenchymal transition through Slug induced repression of [E-cadherin] . Negative_regulation CDH1 MAP2K6 19285010 2046531 A inhibitor , U0126 , *increased* [E-cadherin] or claudin 4 mRNA and protein expression , and potently inhibited cell invasion . Negative_regulation CDH1 MAP2K6 20824291 2341838 Inhibition of signaling *mediated* up-regulation of [E-cadherin] and claudin-4 , and/or decreased expression of matrix metalloproteinases ( MMPs ) such as MMP-2 and MMP-9 , play a role in the TZD induced inhibition of cancer cell invasion . Negative_regulation CDH1 TNF 12503700 1026843 In human bronchial epithelial cells the authors have shown that *induced* a significant decrease of [E-cadherin] and beta-catenin expression . Negative_regulation CDH1 TNF 20350779 2281928 In contrast , NF-kappaB activation by or expression of constitutively active IKK2 *induced* an EMT-phenotype with up-regulation of vimentin and ZEB1 , and down-regulation of [E-cadherin] . Negative_regulation CDH1 TNF 21895660 2532520 *reduced* the expression of [E-cadherin] in HGECs , and IM reversed the reduction . Negative_regulation CDH1 TNF 9558117 500067 IL-1 and *caused* a rapid reduction in FSDDC [E-cadherin] mRNA levels that preceded the decrease in E-cadherin surface expression . Negative_regulation CDH2 IL1B 10491223 646308 TNF-alpha ( 10-100 U/ml ) and ( 10-100 ng/ml ) *suppressed* [N-cadherin] without changing OB-cadherin expression , while PTH ( 1-100 ng/ml ) had no effect on cadherin expression . Negative_regulation CDH2 MMP28 15769936 1424948 The inhibitors GM-6001 and TAPI-O *inhibited* cleavage and/or loss of E- and [N-cadherin] protein expression . Negative_regulation CDH2 MMP28 22489706 2624582 inhibition attenuated ADAM-10 protein 15 days after TBI+BEC and *increased* [N-cadherin] . Negative_regulation CDH2 MMP7 15769936 1424963 The inhibitors GM-6001 and TAPI-O *inhibited* cleavage and/or loss of E- and [N-cadherin] protein expression . Negative_regulation CDH2 MMP7 22489706 2624597 inhibition attenuated ADAM-10 protein 15 days after TBI+BEC and *increased* [N-cadherin] . Negative_regulation CDH2 TGM2 23290789 2764003 Suppression of or the c-Jun-N-terminal kinase (JNK) inhibitor , SP600125 , significantly reduced and over-expression of Tgase-2 *increased* the expression of [N-cadherin] . Negative_regulation CDH2 TNF 10491223 646307 ( 10-100 U/ml ) and IL-1beta ( 10-100 ng/ml ) *suppressed* [N-cadherin] without changing OB-cadherin expression , while PTH ( 1-100 ng/ml ) had no effect on cadherin expression . Negative_regulation CDH5 PECAM1 24425872 2917921 Moreover , we have confirmed that the CD31 ecto-domain plays a key role in specific caspase cascades as well as cell adhesion mediated cell growth and found that deficiency *results* in a reduction in [VE-cadherin] expression . Negative_regulation CDH5 TNF 14734634 1211802 Studies of the mechanism of action showed that CgA inhibits *induced* [VE-cadherin] down-regulation and barrier alteration of cultured endothelial cells , in an indirect manner . Negative_regulation CDK1 CCND1 22851678 2677171 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , p27 ( Kip1 ) , and . Negative_regulation CDK1 CCND1 24399246 2906966 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) ( p21Cip1 , p27Kip1 , p15INK4B ) , and cyclin E were shown to be differentially expressed in latexin overexpressed cells and latexin silenced cells . Negative_regulation CDK1 CDKN1C 11347369 814324 The expression of , a [cyclin dependent kinase] *inhibitor* , is a strong indicator that the cells are exiting the cell cycle and are beginning to differentiate . Negative_regulation CDK1 CDKN1C 11529881 853597 We examine the cell proliferation activity and expression of [cyclin dependent kinase] *inhibitors* of the Cip/Kip family , p21Cip1 , p27Kip1 and , in foetal hamster lungs to determine the expression patterns of the cyclin dependent kinase inhibitors and to clarify the relationship between expression of the cyclin dependent kinase inhibitors and lung development . Negative_regulation CDK1 CDKN1C 15224347 1264945 The expression of ( Kip2 ) , a [cyclin dependent kinase] *inhibitor* that was also in the imprinted region , exhibited some variable increased expression predominantly in hepatic neoplasms from livers of female TG+ rats . Negative_regulation CDK1 CDKN1C 15537824 1367507 In contrast , EGCG accelerates terminal differentiation in normal human epidermal keratinocytes ( NHEK ) mediated partially by up-regulation of , a [cyclin dependent kinase] *inhibitor* that confers growth arrest and differentiation . Negative_regulation CDK1 CDKN1C 16731797 1565994 Differential expression of [cyclin dependent kinase] *inhibitors* , p27Kip1 and , by corticotropin in rat adrenal cortex . Negative_regulation CDK1 CDKN1C 16731797 1566032 An important role for the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p27Kip1 and , in the proliferation and differentiation of adrenal cells has been suggested by their knockout mice , which display adrenal hyperplasia . Negative_regulation CDK1 CDKN1C 18822693 1970534 The aim of this study was to establish the importance of , a unique [cyclin dependent kinase] *inhibitor* , in the oncogenesis of bladder carcinoma . Negative_regulation CDK1 CDKN1C 18981479 1983587 Differentiation of trophoblast stem cells into giant cells is triggered by *inhibition* of [CDK1] activity . Negative_regulation CDK1 CDKN1C 20503313 2263847 A small number of individuals with BWS ( 5-10 % ) have mutations in , a [cyclin dependent kinase] *inhibitor* of G1 cyclin complexes that functions as a negative regulator of cellular growth and proliferation . Negative_regulation CDK1 CDKN1C 21322636 2443291 p21 was found to be a key regulator of this process , because down-regulation of the [cyclin dependent kinase] *inhibitors* p27 ( CDKN1B/KIP1 ) or p57 ( ) or the tumor suppressor p53 ( TP53/LFS1 ) failed to induce proliferation and subsequent dedifferentiation . Negative_regulation CDK1 CDKN1C 22996691 2679047 Expression of , a BMP10 regulated [cyclin dependent kinase] *inhibitor* , was induced in Myocd-/- hearts , while BMP10 activated cardiogenic transcription factors , including NKX2.5 and MEF2c , were repressed . Negative_regulation CDK1 CDKN1C 7550351 323229 Genomic imprinting of , a [cyclin dependent kinase] *inhibitor* , in mouse . Negative_regulation CDK1 CDKN1C 7729683 302206 Cloning of , a [cyclin dependent kinase] *inhibitor* with unique domain structure and tissue distribution . Negative_regulation CDK1 CDKN1C 8923002 397199 The gene for insulin-like growth factor II (IGF2) is normally expressed from the paternal allele , while H19 and , a [cyclin dependent kinase] *inhibitor* , are expressed from the maternal allele . Negative_regulation CDK1 CDKN1C 9311734 455006 these include the gene for insulin-like growth factor II (IGF2) and H19 , which show abnormal imprint-specific expression and/or methylation in 20 % of BWS patients , and , a [cyclin dependent kinase] *inhibitor* , which we found showed biallelic expression in one of nine BWS patients studied . Negative_regulation CDK1 EPHB2 20855497 2325788 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Negative_regulation CDK1 EPHB2 21871886 2491170 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK1 IFI27 10198213 605026 73-kDa heat shock cognate protein interacts directly with , a [cyclin dependent kinase] *inhibitor* , during G1/S transition . Negative_regulation CDK1 IFI27 10198213 605064 In the present study , we demonstrated that 73hsc ( heat shock cognate protein ) , which belongs to the HSP70 family of molecular chaperones , interacts with , an *inhibitor* of [cyclin dependent kinase] , during G1/S transition . Negative_regulation CDK1 IFI27 10510349 651095 The treatment of macrophages with adenosine induces the expression of , a G1 [cyclin dependent kinase] *inhibitor* , in a protein kinase A-dependent way . Negative_regulation CDK1 IFI27 10859299 715242 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in many types of carcinomas . Negative_regulation CDK1 IFI27 10861499 705300 ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has an important role in the progression of cells from G ( 1 ) into S phase of the cell cycle . Negative_regulation CDK1 IFI27 10903892 713397 Minimal requirements for the nuclear localization of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK1 IFI27 11136238 786704 Previous work has shown that cyclin A can be cleaved at Arg-70/Arg-71 by a proteolytic activity present in an in vitro coupled transcription/translation system by using rabbit reticulocyte lysate programmed by plasmid DNA encoding ( KIP1 ) , a [cyclin dependent kinase] *inhibitor* , but not by plasmid DNAs encoding other cyclin dependent kinases inhibitors . Negative_regulation CDK1 IFI27 11164713 782649 [Cyclin dependent kinase] *inhibitors* , p21 ( waf1/cip1 ) and ( kip1 ) , are expressed site- and hair cycle-dependently in rat hair follicles . Negative_regulation CDK1 IFI27 11237531 790101 A major function of , also known as Kip1 , is to bind and *inhibit* [cyclin/cyclin dependent kinase] complexes , thereby blocking cell cycle progression . Negative_regulation CDK1 IFI27 11251953 793934 Low expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is a marker of poor prognosis in synovial sarcoma . Negative_regulation CDK1 IFI27 11251953 793953 Low expression of ( kip1 ) , a dominant [cyclin dependent kinase] *inhibitor* involved in G1-S transition of the cell cycle , recently has been reported to be associated with aggressive tumor growth . Negative_regulation CDK1 IFI27 11301477 803355 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in breast cancer . Negative_regulation CDK1 IFI27 11400230 824386 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , negatively regulates the G1 phase progression of the cell cycle by binding to the cyclin E/cyclin dependent kinase 2 complex . Negative_regulation CDK1 IFI27 11557117 861239 , a [cyclin dependent kinase] *inhibitor* , regulates the progression from G1 into the S phase by binding and inhibiting cyclin/cdks . Negative_regulation CDK1 IFI27 11744034 897884 Levels of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p16 and , were initially high in quiescent isolated cells and tissue ; Negative_regulation CDK1 IFI27 11745414 888954 Herein , expression of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p21 , and p57 and their associated kinase activities were examined in 61 cases of soft tissue smooth muscle tumors . Negative_regulation CDK1 IFI27 11850846 913172 LY294002 also causes an increase in , a [cyclin dependent kinase] *inhibitor* and results in the dephosphorylation of members of the pocket protein family . Negative_regulation CDK1 IFI27 11856766 914391 The differentiation was accompanied by a growth arrest and the upregulation of [cyclin dependent kinase] *inhibitors* , and p57 , as well as cyclin D(1) , whereas cyclin A was downregulated . Negative_regulation CDK1 IFI27 12097295 961264 Reduced expression level of , a [cyclin dependent kinase] *inhibitor* , is associated with high aggressiveness and poor prognosis of various malignant tumors , including gastric carcinoma . Negative_regulation CDK1 IFI27 12465754 1022243 Calcitriol induces a significant G0/G1 arrest and modulates p21 ( Waf/Cip1 ) and ( Kip1 ) , the [cyclin dependent kinase] *inhibitors* . Negative_regulation CDK1 IFI27 12663518 1074515 IP6 strongly increased the expression of CDKIs ( [cyclin dependent kinase] *inhibitors* ) , Cip1/p21 and , without any noticeable changes in G1 CDKs and cyclins , except a slight increase in cyclin D2 . Negative_regulation CDK1 IFI27 12771291 1094732 Parathyroid cell growth in patients with advanced secondary hyperparathyroidism : vitamin D receptor and [cyclin dependent kinase] *inhibitors* , p21 and . Negative_regulation CDK1 IFI27 12943995 1135781 We also observed a simultaneous increase in the expression of [cyclin-dependent-kinase] *inhibitors* , p21 , , p15 and p16 , associated with a loss in expression of Cyclin-A2 and Cyclin-E . Negative_regulation CDK1 IFI27 14618613 1188014 To examine the mechanism of the troglitazone induced growth inhibition , we determined ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , expression by Western blot analysis in troglitazone treated HLF cells . Negative_regulation CDK1 IFI27 15048878 1225234 We conclude that substrate dependent acquisition of proliferative phenotypes following repeated cycles of AAM injury correlates with modulation of the [cyclin dependent kinase] *inhibitors* , and p21 . Negative_regulation CDK1 IFI27 15138205 1246181 Gastric cells chronically exposed to H pylori in vitro develop resistance to apoptosis associated with low levels of , a [cyclin dependent kinase] *inhibitor* and haplo insufficient tumour suppressor gene that is downregulated in gastric cancer . Negative_regulation CDK1 IFI27 15224009 1264872 A high level of , an *inhibitor* of [cyclin dependent kinase] that correlates with the degree of in vitro apoptosis , is found in B-CLL cells . Negative_regulation CDK1 IFI27 15263796 1275065 The prognostic significance of cyclins D1 , E and [cyclin dependent kinase] *inhibitors* p21 ( Waf1/Cip1 ) , ( Kip1 ) in determining the risk of recurrence and progression with both univariate ( log rank test ) and multivariate ( Cox regression ) methods of analysis showed no statistically significance differences . Negative_regulation CDK1 IFI27 15378017 1323999 In the present study , we investigated the consequences of the combined loss of either of two [cyclin dependent kinase] *inhibitors* , p21 and , in cooperation with deletion of the INK4a/ARF locus . Negative_regulation CDK1 IFI27 15474987 1354672 Under the same conditions , adding MG or HK to VD3 or ATRA treatment further enlarged the G0/G1 cell population and increased the expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK1 IFI27 15491288 1321366 In addition , in myeloma cells subjected to growth-factor starvation , the upregulation of PGP9.5 was observed in association with that of ( Kip1 ) , a [cyclin-dependent-kinase] *inhibitor* , although the upregulation caused by irradiation was milder . Negative_regulation CDK1 IFI27 15799773 1390554 Several genes , including insulin-like growth factor 1 (IGF-1) and [cyclin dependent kinase] *inhibitor* ( ( Kip1 ) ) were induced by both injury types and these may have potential clinical application as markers of tissue damage . Negative_regulation CDK1 IFI27 15930262 1414417 Here , we found that VDUP1-/- fibroblast cells proliferated more rapidly compared with wild-type cells with reduced expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK1 IFI27 16020508 1465802 Tregs were blocked from cell cycle progression due to decrease of cyclin E and cyclin A and increase of ( p27kip [cyclin dependent kinase] *inhibitor* ) . Negative_regulation CDK1 IFI27 16039115 1473592 Levels of expression of cyclins , cyclin dependent kinases and [cyclin dependent kinase] *inhibitors* , p21 and , were analysed by western blotting . Negative_regulation CDK1 IFI27 16328436 1503614 [Cyclin dependent kinase] *inhibitors* CIP1 ( p21 ) and KIP1 ( ) in ovarian cancer . Negative_regulation CDK1 IFI27 16427178 1567158 In this study , under treatment with various concentrations of PA in MDA-MB 231 cell line , we checked mRNA levels for cyclin A and cyclin B1 and the protein levels of cyclin A and cyclin B1 , Cdc2 ( cyclin dependent kinases ) , p21 ( waf1/cip1 ) and ( Kip1 ) ( [cyclin dependent kinase] *inhibitors* ) , Cdc25C , Chk2 and Wee1 kinase ( cyclin dependent kinase relative factors ) in cell cycle G2/M phase . Negative_regulation CDK1 IFI27 16436005 1495298 ( kip1 ) , a universal [cyclin dependent kinase] *inhibitor* , is a useful marker for predicting clinical aggressiveness with various human tumors . Negative_regulation CDK1 IFI27 16564150 1555711 In contrast , protein levels of , a [cyclin dependent kinase] *inhibitor* , are increased after induction of ER-stress using tunicamycin . Negative_regulation CDK1 IFI27 17360552 1712741 As proof of principle , we studied the consequence of sporadic loss of , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK1 IFI27 17918155 1843860 Furthermore , we find that the growth inhibitory dose of R1881 leads to increases in the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21 and as well as to G1 arrest . Negative_regulation CDK1 IFI27 17979972 1874275 Terrein was found to downregulate cyclin B1 and Cdc2 without Cdc2 phosphorylation , but upregulated ( KIP1 ) ( p27 ) , a known *inhibitor* of [cyclin dependent kinase] . Negative_regulation CDK1 IFI27 18583941 1953281 Roles of [cyclin dependent kinase] *inhibitors* , p21/Cip1 ( p21 ) and p27/Kip1 ( ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation CDK1 IFI27 19026637 2022719 Activation of ERK1/2 was not affected by MacCM , and neither was the expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK1 IFI27 19147535 2026266 Two [cyclin dependent kinase] *inhibitors* , p18 ( Ink4c ) and ( Kip1 ) , are required for proper cerebellar development . Negative_regulation CDK1 IFI27 19276255 2046184 In retrospective studies , loss of ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has been associated with poor prognosis following colorectal cancer treatment . Negative_regulation CDK1 IFI27 19321452 2073929 Although HSC70 directly bound to ( Kip1 ) ( a [cyclin dependent kinase] *inhibitor* ) , histatin 3 increased the binding between those proteins but not with a peptide capable of binding to HSC70 . Negative_regulation CDK1 IFI27 19538337 2103556 In this study , we examined the role of melatonin on synoviocyte proliferation in primary cultured human fibroblast-like synoviocytes ( FLSs ) by analyzing protein expression of P21 ( CIP1 ) ( P21 ) and ( KIP1 ) ( P27 ) , the [cyclin dependent kinase] *inhibitors* that are important in cell cycle control , and the phosphorylation of mitogen activated protein kinases ( MAPKs ) . Negative_regulation CDK1 IFI27 19598246 2149807 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is also known to demarcate the prosensory region in the cochlear primordium , which consists of the sensory progenitors that have completed their terminal mitoses . Negative_regulation CDK1 IFI27 19720293 2133700 Trastuzumab , a humanized antibody directed against the Her2 receptor , induces the expression of ( kip1 ) , an intranuclear [cyclin dependent kinase] *inhibitor* in some breast cancer cells . Negative_regulation CDK1 IFI27 21443540 2438438 Furthermore , NS expression was associated with cellular proliferation in OSCC cell lines using siRNA , which upregulated , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK1 IFI27 21980125 2502925 Further , deletion of AMPKa2 but not AMPKa1 reduced the level of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , and increased the level of S-phase kinase associated protein 2 ( Skp2 ) , a known E3 ubiquitin ligase for p27 ( Kip1 ) , through activation of p52 nuclear factor kappa B ( NF-?B ) -2 . Negative_regulation CDK1 IFI27 22154697 2563114 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) of the CIP/KIP family , p21 , and p57 , mediate cell cycle inhibition . Negative_regulation CDK1 IFI27 22460505 2637114 Cell cycle analysis indicated thioridazine induced the down-regulation of cyclin D1 , cyclin A and CDK4 , and the induction of p21 and , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK1 IFI27 22851678 2677173 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , ( Kip1 ) , and cyclin D1 . Negative_regulation CDK1 IFI27 23255047 2827350 Skp2 mediated degradation of , a [cyclin dependent kinase] *inhibitor* , is involved in cell cycle regulation . Negative_regulation CDK1 IFI27 23721824 2819694 miR-370 induced proliferation was correlated with the downregulation of [cyclin dependent kinase] *inhibitors* , ( Kip1 ) and p21 ( Cip1 ) , and the upregulation of the cell cycle regulator cyclin D1 . Negative_regulation CDK1 IFI27 23888319 2901985 Our results found that curcumin inhibited cell proliferation , which was associated with upregulation of the [cyclin dependent kinase] *inhibitors* , and p21 , and downregulation of cyclin D1 . Negative_regulation CDK1 IFI27 23944957 2887958 We determined whether proliferation and IL-6 release are abnormal in ASM cells ( ASMCs ) from patients with severe asthma , and whether these features could be mediated by microRNA-221 and microRNA-222 , through modulation of the [cyclin dependent kinase] *inhibitors* , p21 ( WAF1 ) and ( kip1 ) . Negative_regulation CDK1 IFI27 24067984 2867163 Western blot analysis of key cell cycle regulators revealed that K-Rta mediated cell cycle arrest was associated with a decrease in cyclin A and phosphorylated Rb ( pS807/pS811 ) protein levels , both markers of S phase progression , and an increase in protein levels for , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK1 IFI27 24708177 2938865 Recently , STMN1 was reported to interact with , an *inhibitor* of [cyclin dependent kinase] complexes . Negative_regulation CDK1 IFI27 8654372 366860 Expression of Zta results in induction of the tumor suppressor protein , p53 , and the [cyclin dependent kinase] *inhibitors* , p21 and , as well as accumulation of hypophosphorylated pRb . Negative_regulation CDK1 IFI27 8845296 337808 We have examined the level of cyclin E , a G1 cyclin , and , a [cyclin dependent kinase] *inhibitor* , in BALB/c 3T3 cells . Negative_regulation CDK1 IFI27 9268291 449776 Our data showed that both and Np27 *inhibited* [CDC2] kinase activity . Negative_regulation CDK1 IFI27 9616167 509576 The identification of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* that contributes to cell cycle arrest and represents a link between extracellular signals and cell cycle , prompted us to study p27 protein in the lymphocytes from 88 patients with B-CLL and 32 patients with other chronic B-lymphoproliferative disorders . Negative_regulation CDK1 IFI27 9746784 532990 The ( kip-1 ) , a [cyclin dependent kinase] *inhibitor* which is important in blocking the cell cycle , was induced more quickly and potently by Ro 25-9716 ( 10 ( -7 ) mol/L , 0 to 5 days ) than by 1,25D3 , suggesting a possible mechanism by which these analogs inhibit proliferation of leukemic growth . Negative_regulation CDK1 IFI27 9891946 558534 Hence , we have determined the cell cycle profile , expressions and activities of the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21CIP1 and , during rat ventricular myocyte development . Negative_regulation CDK1 ITGA9 22138449 2536208 Furthermore , effects of p21 , a [cyclin dependent kinase] *inhibitor* , and integrin a9 ( ) were examined . Negative_regulation CDK1 MAP2K6 10597223 573351 p21Cip1/Waf1 [cyclin dependent kinase] inhibitor ( p21 ) is *inducible* by Raf and ( MAPKK ) , but the level of regulation is unknown . Negative_regulation CDK1 MAP2K6 21871886 2491176 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK1 MAP2K6 9450967 484043 In other experiments , p42MAPK activation by or by Mos *inhibited* [Cdc2] activation by cyclin B. PD098059 , a specific inhibitor of MEK , blocked the effects of MEK ( QP ) and Mos . Negative_regulation CDK1 RARB 21868513 2473717 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Negative_regulation CDK1 TNF 16520149 1531136 The response of tumors to MET-stress depends on their mutational status , however , it always involves inhibition of [CDK1] and in most cases the upregulation of p21 , p27 , GADDs and 14-3-3sigma in *response* to upregulation of TGF-beta , IRF-1 , , Rb and/or MDA-7 and the downregulation of PI3K , RAS and NF-kappaB . Negative_regulation CDK10 CCND1 22851678 2677177 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , p27 ( Kip1 ) , and . Negative_regulation CDK10 CCND1 24399246 2906968 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) ( p21Cip1 , p27Kip1 , p15INK4B ) , and cyclin E were shown to be differentially expressed in latexin overexpressed cells and latexin silenced cells . Negative_regulation CDK10 CDKN1C 11347369 814326 The expression of , a [cyclin dependent kinase] *inhibitor* , is a strong indicator that the cells are exiting the cell cycle and are beginning to differentiate . Negative_regulation CDK10 CDKN1C 11529881 853603 We examine the cell proliferation activity and expression of [cyclin dependent kinase] *inhibitors* of the Cip/Kip family , p21Cip1 , p27Kip1 and , in foetal hamster lungs to determine the expression patterns of the cyclin dependent kinase inhibitors and to clarify the relationship between expression of the cyclin dependent kinase inhibitors and lung development . Negative_regulation CDK10 CDKN1C 15224347 1264947 The expression of ( Kip2 ) , a [cyclin dependent kinase] *inhibitor* that was also in the imprinted region , exhibited some variable increased expression predominantly in hepatic neoplasms from livers of female TG+ rats . Negative_regulation CDK10 CDKN1C 15537824 1367509 In contrast , EGCG accelerates terminal differentiation in normal human epidermal keratinocytes ( NHEK ) mediated partially by up-regulation of , a [cyclin dependent kinase] *inhibitor* that confers growth arrest and differentiation . Negative_regulation CDK10 CDKN1C 16731797 1565998 Differential expression of [cyclin dependent kinase] *inhibitors* , p27Kip1 and , by corticotropin in rat adrenal cortex . Negative_regulation CDK10 CDKN1C 16731797 1566036 An important role for the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p27Kip1 and , in the proliferation and differentiation of adrenal cells has been suggested by their knockout mice , which display adrenal hyperplasia . Negative_regulation CDK10 CDKN1C 18822693 1970536 The aim of this study was to establish the importance of , a unique [cyclin dependent kinase] *inhibitor* , in the oncogenesis of bladder carcinoma . Negative_regulation CDK10 CDKN1C 20503313 2263849 A small number of individuals with BWS ( 5-10 % ) have mutations in , a [cyclin dependent kinase] *inhibitor* of G1 cyclin complexes that functions as a negative regulator of cellular growth and proliferation . Negative_regulation CDK10 CDKN1C 21322636 2443295 p21 was found to be a key regulator of this process , because down-regulation of the [cyclin dependent kinase] *inhibitors* p27 ( CDKN1B/KIP1 ) or p57 ( ) or the tumor suppressor p53 ( TP53/LFS1 ) failed to induce proliferation and subsequent dedifferentiation . Negative_regulation CDK10 CDKN1C 22996691 2679049 Expression of , a BMP10 regulated [cyclin dependent kinase] *inhibitor* , was induced in Myocd-/- hearts , while BMP10 activated cardiogenic transcription factors , including NKX2.5 and MEF2c , were repressed . Negative_regulation CDK10 CDKN1C 7550351 323231 Genomic imprinting of , a [cyclin dependent kinase] *inhibitor* , in mouse . Negative_regulation CDK10 CDKN1C 7729683 302208 Cloning of , a [cyclin dependent kinase] *inhibitor* with unique domain structure and tissue distribution . Negative_regulation CDK10 CDKN1C 8923002 397203 The gene for insulin-like growth factor II (IGF2) is normally expressed from the paternal allele , while H19 and , a [cyclin dependent kinase] *inhibitor* , are expressed from the maternal allele . Negative_regulation CDK10 CDKN1C 9311734 455008 these include the gene for insulin-like growth factor II (IGF2) and H19 , which show abnormal imprint-specific expression and/or methylation in 20 % of BWS patients , and , a [cyclin dependent kinase] *inhibitor* , which we found showed biallelic expression in one of nine BWS patients studied . Negative_regulation CDK10 EPHB2 20855497 2325795 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Negative_regulation CDK10 EPHB2 21871886 2491190 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK10 IFI27 10198213 605030 73-kDa heat shock cognate protein interacts directly with , a [cyclin dependent kinase] *inhibitor* , during G1/S transition . Negative_regulation CDK10 IFI27 10198213 605068 In the present study , we demonstrated that 73hsc ( heat shock cognate protein ) , which belongs to the HSP70 family of molecular chaperones , interacts with , an *inhibitor* of [cyclin dependent kinase] , during G1/S transition . Negative_regulation CDK10 IFI27 10510349 651099 The treatment of macrophages with adenosine induces the expression of , a G1 [cyclin dependent kinase] *inhibitor* , in a protein kinase A-dependent way . Negative_regulation CDK10 IFI27 10859299 715244 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in many types of carcinomas . Negative_regulation CDK10 IFI27 10861499 705302 ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has an important role in the progression of cells from G ( 1 ) into S phase of the cell cycle . Negative_regulation CDK10 IFI27 10903892 713399 Minimal requirements for the nuclear localization of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK10 IFI27 11136238 786706 Previous work has shown that cyclin A can be cleaved at Arg-70/Arg-71 by a proteolytic activity present in an in vitro coupled transcription/translation system by using rabbit reticulocyte lysate programmed by plasmid DNA encoding ( KIP1 ) , a [cyclin dependent kinase] *inhibitor* , but not by plasmid DNAs encoding other cyclin dependent kinases inhibitors . Negative_regulation CDK10 IFI27 11164713 782653 [Cyclin dependent kinase] *inhibitors* , p21 ( waf1/cip1 ) and ( kip1 ) , are expressed site- and hair cycle-dependently in rat hair follicles . Negative_regulation CDK10 IFI27 11237531 790103 A major function of , also known as Kip1 , is to bind and *inhibit* [cyclin/cyclin dependent kinase] complexes , thereby blocking cell cycle progression . Negative_regulation CDK10 IFI27 11251953 793936 Low expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is a marker of poor prognosis in synovial sarcoma . Negative_regulation CDK10 IFI27 11251953 793955 Low expression of ( kip1 ) , a dominant [cyclin dependent kinase] *inhibitor* involved in G1-S transition of the cell cycle , recently has been reported to be associated with aggressive tumor growth . Negative_regulation CDK10 IFI27 11301477 803357 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in breast cancer . Negative_regulation CDK10 IFI27 11400230 824388 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , negatively regulates the G1 phase progression of the cell cycle by binding to the cyclin E/cyclin dependent kinase 2 complex . Negative_regulation CDK10 IFI27 11557117 861241 , a [cyclin dependent kinase] *inhibitor* , regulates the progression from G1 into the S phase by binding and inhibiting cyclin/cdks . Negative_regulation CDK10 IFI27 11744034 897886 Levels of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p16 and , were initially high in quiescent isolated cells and tissue ; Negative_regulation CDK10 IFI27 11745414 888956 Herein , expression of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p21 , and p57 and their associated kinase activities were examined in 61 cases of soft tissue smooth muscle tumors . Negative_regulation CDK10 IFI27 11850846 913176 LY294002 also causes an increase in , a [cyclin dependent kinase] *inhibitor* and results in the dephosphorylation of members of the pocket protein family . Negative_regulation CDK10 IFI27 11856766 914393 The differentiation was accompanied by a growth arrest and the upregulation of [cyclin dependent kinase] *inhibitors* , and p57 , as well as cyclin D(1) , whereas cyclin A was downregulated . Negative_regulation CDK10 IFI27 12097295 961266 Reduced expression level of , a [cyclin dependent kinase] *inhibitor* , is associated with high aggressiveness and poor prognosis of various malignant tumors , including gastric carcinoma . Negative_regulation CDK10 IFI27 12465754 1022247 Calcitriol induces a significant G0/G1 arrest and modulates p21 ( Waf/Cip1 ) and ( Kip1 ) , the [cyclin dependent kinase] *inhibitors* . Negative_regulation CDK10 IFI27 12663518 1074523 IP6 strongly increased the expression of CDKIs ( [cyclin dependent kinase] *inhibitors* ) , Cip1/p21 and , without any noticeable changes in G1 CDKs and cyclins , except a slight increase in cyclin D2 . Negative_regulation CDK10 IFI27 12771291 1094736 Parathyroid cell growth in patients with advanced secondary hyperparathyroidism : vitamin D receptor and [cyclin dependent kinase] *inhibitors* , p21 and . Negative_regulation CDK10 IFI27 12943995 1135785 We also observed a simultaneous increase in the expression of [cyclin-dependent-kinase] *inhibitors* , p21 , , p15 and p16 , associated with a loss in expression of Cyclin-A2 and Cyclin-E . Negative_regulation CDK10 IFI27 14618613 1188016 To examine the mechanism of the troglitazone induced growth inhibition , we determined ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , expression by Western blot analysis in troglitazone treated HLF cells . Negative_regulation CDK10 IFI27 15048878 1225238 We conclude that substrate dependent acquisition of proliferative phenotypes following repeated cycles of AAM injury correlates with modulation of the [cyclin dependent kinase] *inhibitors* , and p21 . Negative_regulation CDK10 IFI27 15138205 1246183 Gastric cells chronically exposed to H pylori in vitro develop resistance to apoptosis associated with low levels of , a [cyclin dependent kinase] *inhibitor* and haplo insufficient tumour suppressor gene that is downregulated in gastric cancer . Negative_regulation CDK10 IFI27 15224009 1264876 A high level of , an *inhibitor* of [cyclin dependent kinase] that correlates with the degree of in vitro apoptosis , is found in B-CLL cells . Negative_regulation CDK10 IFI27 15263796 1275067 The prognostic significance of cyclins D1 , E and [cyclin dependent kinase] *inhibitors* p21 ( Waf1/Cip1 ) , ( Kip1 ) in determining the risk of recurrence and progression with both univariate ( log rank test ) and multivariate ( Cox regression ) methods of analysis showed no statistically significance differences . Negative_regulation CDK10 IFI27 15378017 1324003 In the present study , we investigated the consequences of the combined loss of either of two [cyclin dependent kinase] *inhibitors* , p21 and , in cooperation with deletion of the INK4a/ARF locus . Negative_regulation CDK10 IFI27 15474987 1354674 Under the same conditions , adding MG or HK to VD3 or ATRA treatment further enlarged the G0/G1 cell population and increased the expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK10 IFI27 15491288 1321368 In addition , in myeloma cells subjected to growth-factor starvation , the upregulation of PGP9.5 was observed in association with that of ( Kip1 ) , a [cyclin-dependent-kinase] *inhibitor* , although the upregulation caused by irradiation was milder . Negative_regulation CDK10 IFI27 15799773 1390556 Several genes , including insulin-like growth factor 1 (IGF-1) and [cyclin dependent kinase] *inhibitor* ( ( Kip1 ) ) were induced by both injury types and these may have potential clinical application as markers of tissue damage . Negative_regulation CDK10 IFI27 15930262 1414419 Here , we found that VDUP1-/- fibroblast cells proliferated more rapidly compared with wild-type cells with reduced expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK10 IFI27 16020508 1465806 Tregs were blocked from cell cycle progression due to decrease of cyclin E and cyclin A and increase of ( p27kip [cyclin dependent kinase] *inhibitor* ) . Negative_regulation CDK10 IFI27 16039115 1473596 Levels of expression of cyclins , cyclin dependent kinases and [cyclin dependent kinase] *inhibitors* , p21 and , were analysed by western blotting . Negative_regulation CDK10 IFI27 16328436 1503616 [Cyclin dependent kinase] *inhibitors* CIP1 ( p21 ) and KIP1 ( ) in ovarian cancer . Negative_regulation CDK10 IFI27 16427178 1567162 In this study , under treatment with various concentrations of PA in MDA-MB 231 cell line , we checked mRNA levels for cyclin A and cyclin B1 and the protein levels of cyclin A and cyclin B1 , Cdc2 ( cyclin dependent kinases ) , p21 ( waf1/cip1 ) and ( Kip1 ) ( [cyclin dependent kinase] *inhibitors* ) , Cdc25C , Chk2 and Wee1 kinase ( cyclin dependent kinase relative factors ) in cell cycle G2/M phase . Negative_regulation CDK10 IFI27 16436005 1495300 ( kip1 ) , a universal [cyclin dependent kinase] *inhibitor* , is a useful marker for predicting clinical aggressiveness with various human tumors . Negative_regulation CDK10 IFI27 16564150 1555713 In contrast , protein levels of , a [cyclin dependent kinase] *inhibitor* , are increased after induction of ER-stress using tunicamycin . Negative_regulation CDK10 IFI27 17360552 1712745 As proof of principle , we studied the consequence of sporadic loss of , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK10 IFI27 17918155 1843864 Furthermore , we find that the growth inhibitory dose of R1881 leads to increases in the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21 and as well as to G1 arrest . Negative_regulation CDK10 IFI27 17979972 1874277 Terrein was found to downregulate cyclin B1 and Cdc2 without Cdc2 phosphorylation , but upregulated ( KIP1 ) ( p27 ) , a known *inhibitor* of [cyclin dependent kinase] . Negative_regulation CDK10 IFI27 18583941 1953289 Roles of [cyclin dependent kinase] *inhibitors* , p21/Cip1 ( p21 ) and p27/Kip1 ( ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation CDK10 IFI27 19026637 2022721 Activation of ERK1/2 was not affected by MacCM , and neither was the expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK10 IFI27 19147535 2026270 Two [cyclin dependent kinase] *inhibitors* , p18 ( Ink4c ) and ( Kip1 ) , are required for proper cerebellar development . Negative_regulation CDK10 IFI27 19276255 2046186 In retrospective studies , loss of ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has been associated with poor prognosis following colorectal cancer treatment . Negative_regulation CDK10 IFI27 19321452 2073931 Although HSC70 directly bound to ( Kip1 ) ( a [cyclin dependent kinase] *inhibitor* ) , histatin 3 increased the binding between those proteins but not with a peptide capable of binding to HSC70 . Negative_regulation CDK10 IFI27 19538337 2103560 In this study , we examined the role of melatonin on synoviocyte proliferation in primary cultured human fibroblast-like synoviocytes ( FLSs ) by analyzing protein expression of P21 ( CIP1 ) ( P21 ) and ( KIP1 ) ( P27 ) , the [cyclin dependent kinase] *inhibitors* that are important in cell cycle control , and the phosphorylation of mitogen activated protein kinases ( MAPKs ) . Negative_regulation CDK10 IFI27 19598246 2149809 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is also known to demarcate the prosensory region in the cochlear primordium , which consists of the sensory progenitors that have completed their terminal mitoses . Negative_regulation CDK10 IFI27 19720293 2133702 Trastuzumab , a humanized antibody directed against the Her2 receptor , induces the expression of ( kip1 ) , an intranuclear [cyclin dependent kinase] *inhibitor* in some breast cancer cells . Negative_regulation CDK10 IFI27 21443540 2438440 Furthermore , NS expression was associated with cellular proliferation in OSCC cell lines using siRNA , which upregulated , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK10 IFI27 21980125 2502927 Further , deletion of AMPKa2 but not AMPKa1 reduced the level of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , and increased the level of S-phase kinase associated protein 2 ( Skp2 ) , a known E3 ubiquitin ligase for p27 ( Kip1 ) , through activation of p52 nuclear factor kappa B ( NF-?B ) -2 . Negative_regulation CDK10 IFI27 22154697 2563116 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) of the CIP/KIP family , p21 , and p57 , mediate cell cycle inhibition . Negative_regulation CDK10 IFI27 22460505 2637118 Cell cycle analysis indicated thioridazine induced the down-regulation of cyclin D1 , cyclin A and CDK4 , and the induction of p21 and , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK10 IFI27 22851678 2677179 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , ( Kip1 ) , and cyclin D1 . Negative_regulation CDK10 IFI27 23255047 2827352 Skp2 mediated degradation of , a [cyclin dependent kinase] *inhibitor* , is involved in cell cycle regulation . Negative_regulation CDK10 IFI27 23721824 2819698 miR-370 induced proliferation was correlated with the downregulation of [cyclin dependent kinase] *inhibitors* , ( Kip1 ) and p21 ( Cip1 ) , and the upregulation of the cell cycle regulator cyclin D1 . Negative_regulation CDK10 IFI27 23888319 2901989 Our results found that curcumin inhibited cell proliferation , which was associated with upregulation of the [cyclin dependent kinase] *inhibitors* , and p21 , and downregulation of cyclin D1 . Negative_regulation CDK10 IFI27 23944957 2887962 We determined whether proliferation and IL-6 release are abnormal in ASM cells ( ASMCs ) from patients with severe asthma , and whether these features could be mediated by microRNA-221 and microRNA-222 , through modulation of the [cyclin dependent kinase] *inhibitors* , p21 ( WAF1 ) and ( kip1 ) . Negative_regulation CDK10 IFI27 24067984 2867165 Western blot analysis of key cell cycle regulators revealed that K-Rta mediated cell cycle arrest was associated with a decrease in cyclin A and phosphorylated Rb ( pS807/pS811 ) protein levels , both markers of S phase progression , and an increase in protein levels for , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK10 IFI27 24708177 2938867 Recently , STMN1 was reported to interact with , an *inhibitor* of [cyclin dependent kinase] complexes . Negative_regulation CDK10 IFI27 8654372 366864 Expression of Zta results in induction of the tumor suppressor protein , p53 , and the [cyclin dependent kinase] *inhibitors* , p21 and , as well as accumulation of hypophosphorylated pRb . Negative_regulation CDK10 IFI27 8845296 337814 We have examined the level of cyclin E , a G1 cyclin , and , a [cyclin dependent kinase] *inhibitor* , in BALB/c 3T3 cells . Negative_regulation CDK10 IFI27 9616167 509578 The identification of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* that contributes to cell cycle arrest and represents a link between extracellular signals and cell cycle , prompted us to study p27 protein in the lymphocytes from 88 patients with B-CLL and 32 patients with other chronic B-lymphoproliferative disorders . Negative_regulation CDK10 IFI27 9746784 532992 The ( kip-1 ) , a [cyclin dependent kinase] *inhibitor* which is important in blocking the cell cycle , was induced more quickly and potently by Ro 25-9716 ( 10 ( -7 ) mol/L , 0 to 5 days ) than by 1,25D3 , suggesting a possible mechanism by which these analogs inhibit proliferation of leukemic growth . Negative_regulation CDK10 IFI27 9891946 558542 Hence , we have determined the cell cycle profile , expressions and activities of the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21CIP1 and , during rat ventricular myocyte development . Negative_regulation CDK10 ITGA9 22138449 2536210 Furthermore , effects of p21 , a [cyclin dependent kinase] *inhibitor* , and integrin a9 ( ) were examined . Negative_regulation CDK10 MAP2K6 10597223 573375 p21Cip1/Waf1 [cyclin dependent kinase] inhibitor ( p21 ) is *inducible* by Raf and ( MAPKK ) , but the level of regulation is unknown . Negative_regulation CDK10 MAP2K6 21871886 2491196 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK10 RARB 21868513 2473719 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Negative_regulation CDK12 CCND1 22851678 2677210 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , p27 ( Kip1 ) , and . Negative_regulation CDK12 CCND1 24399246 2906979 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) ( p21Cip1 , p27Kip1 , p15INK4B ) , and cyclin E were shown to be differentially expressed in latexin overexpressed cells and latexin silenced cells . Negative_regulation CDK12 CDKN1C 11347369 814337 The expression of , a [cyclin dependent kinase] *inhibitor* , is a strong indicator that the cells are exiting the cell cycle and are beginning to differentiate . Negative_regulation CDK12 CDKN1C 11529881 853636 We examine the cell proliferation activity and expression of [cyclin dependent kinase] *inhibitors* of the Cip/Kip family , p21Cip1 , p27Kip1 and , in foetal hamster lungs to determine the expression patterns of the cyclin dependent kinase inhibitors and to clarify the relationship between expression of the cyclin dependent kinase inhibitors and lung development . Negative_regulation CDK12 CDKN1C 15224347 1264958 The expression of ( Kip2 ) , a [cyclin dependent kinase] *inhibitor* that was also in the imprinted region , exhibited some variable increased expression predominantly in hepatic neoplasms from livers of female TG+ rats . Negative_regulation CDK12 CDKN1C 15537824 1367520 In contrast , EGCG accelerates terminal differentiation in normal human epidermal keratinocytes ( NHEK ) mediated partially by up-regulation of , a [cyclin dependent kinase] *inhibitor* that confers growth arrest and differentiation . Negative_regulation CDK12 CDKN1C 16731797 1566020 Differential expression of [cyclin dependent kinase] *inhibitors* , p27Kip1 and , by corticotropin in rat adrenal cortex . Negative_regulation CDK12 CDKN1C 16731797 1566058 An important role for the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p27Kip1 and , in the proliferation and differentiation of adrenal cells has been suggested by their knockout mice , which display adrenal hyperplasia . Negative_regulation CDK12 CDKN1C 18822693 1970547 The aim of this study was to establish the importance of , a unique [cyclin dependent kinase] *inhibitor* , in the oncogenesis of bladder carcinoma . Negative_regulation CDK12 CDKN1C 20503313 2263860 A small number of individuals with BWS ( 5-10 % ) have mutations in , a [cyclin dependent kinase] *inhibitor* of G1 cyclin complexes that functions as a negative regulator of cellular growth and proliferation . Negative_regulation CDK12 CDKN1C 21322636 2443317 p21 was found to be a key regulator of this process , because down-regulation of the [cyclin dependent kinase] *inhibitors* p27 ( CDKN1B/KIP1 ) or p57 ( ) or the tumor suppressor p53 ( TP53/LFS1 ) failed to induce proliferation and subsequent dedifferentiation . Negative_regulation CDK12 CDKN1C 22996691 2679060 Expression of , a BMP10 regulated [cyclin dependent kinase] *inhibitor* , was induced in Myocd-/- hearts , while BMP10 activated cardiogenic transcription factors , including NKX2.5 and MEF2c , were repressed . Negative_regulation CDK12 CDKN1C 7550351 323242 Genomic imprinting of , a [cyclin dependent kinase] *inhibitor* , in mouse . Negative_regulation CDK12 CDKN1C 7729683 302219 Cloning of , a [cyclin dependent kinase] *inhibitor* with unique domain structure and tissue distribution . Negative_regulation CDK12 CDKN1C 8923002 397225 The gene for insulin-like growth factor II (IGF2) is normally expressed from the paternal allele , while H19 and , a [cyclin dependent kinase] *inhibitor* , are expressed from the maternal allele . Negative_regulation CDK12 CDKN1C 9311734 455019 these include the gene for insulin-like growth factor II (IGF2) and H19 , which show abnormal imprint-specific expression and/or methylation in 20 % of BWS patients , and , a [cyclin dependent kinase] *inhibitor* , which we found showed biallelic expression in one of nine BWS patients studied . Negative_regulation CDK12 EPHB2 20855497 2325830 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Negative_regulation CDK12 EPHB2 21871886 2491318 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK12 IFI27 10198213 605052 73-kDa heat shock cognate protein interacts directly with , a [cyclin dependent kinase] *inhibitor* , during G1/S transition . Negative_regulation CDK12 IFI27 10198213 605090 In the present study , we demonstrated that 73hsc ( heat shock cognate protein ) , which belongs to the HSP70 family of molecular chaperones , interacts with , an *inhibitor* of [cyclin dependent kinase] , during G1/S transition . Negative_regulation CDK12 IFI27 10510349 651121 The treatment of macrophages with adenosine induces the expression of , a G1 [cyclin dependent kinase] *inhibitor* , in a protein kinase A-dependent way . Negative_regulation CDK12 IFI27 10859299 715255 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in many types of carcinomas . Negative_regulation CDK12 IFI27 10861499 705313 ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has an important role in the progression of cells from G ( 1 ) into S phase of the cell cycle . Negative_regulation CDK12 IFI27 10903892 713410 Minimal requirements for the nuclear localization of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK12 IFI27 11136238 786717 Previous work has shown that cyclin A can be cleaved at Arg-70/Arg-71 by a proteolytic activity present in an in vitro coupled transcription/translation system by using rabbit reticulocyte lysate programmed by plasmid DNA encoding ( KIP1 ) , a [cyclin dependent kinase] *inhibitor* , but not by plasmid DNAs encoding other cyclin dependent kinases inhibitors . Negative_regulation CDK12 IFI27 11164713 782675 [Cyclin dependent kinase] *inhibitors* , p21 ( waf1/cip1 ) and ( kip1 ) , are expressed site- and hair cycle-dependently in rat hair follicles . Negative_regulation CDK12 IFI27 11237531 790114 A major function of , also known as Kip1 , is to bind and *inhibit* [cyclin/cyclin dependent kinase] complexes , thereby blocking cell cycle progression . Negative_regulation CDK12 IFI27 11251953 793947 Low expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is a marker of poor prognosis in synovial sarcoma . Negative_regulation CDK12 IFI27 11251953 793966 Low expression of ( kip1 ) , a dominant [cyclin dependent kinase] *inhibitor* involved in G1-S transition of the cell cycle , recently has been reported to be associated with aggressive tumor growth . Negative_regulation CDK12 IFI27 11301477 803368 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in breast cancer . Negative_regulation CDK12 IFI27 11400230 824399 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , negatively regulates the G1 phase progression of the cell cycle by binding to the cyclin E/cyclin dependent kinase 2 complex . Negative_regulation CDK12 IFI27 11557117 861252 , a [cyclin dependent kinase] *inhibitor* , regulates the progression from G1 into the S phase by binding and inhibiting cyclin/cdks . Negative_regulation CDK12 IFI27 11744034 897897 Levels of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p16 and , were initially high in quiescent isolated cells and tissue ; Negative_regulation CDK12 IFI27 11745414 888967 Herein , expression of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p21 , and p57 and their associated kinase activities were examined in 61 cases of soft tissue smooth muscle tumors . Negative_regulation CDK12 IFI27 11850846 913198 LY294002 also causes an increase in , a [cyclin dependent kinase] *inhibitor* and results in the dephosphorylation of members of the pocket protein family . Negative_regulation CDK12 IFI27 11856766 914404 The differentiation was accompanied by a growth arrest and the upregulation of [cyclin dependent kinase] *inhibitors* , and p57 , as well as cyclin D(1) , whereas cyclin A was downregulated . Negative_regulation CDK12 IFI27 12097295 961277 Reduced expression level of , a [cyclin dependent kinase] *inhibitor* , is associated with high aggressiveness and poor prognosis of various malignant tumors , including gastric carcinoma . Negative_regulation CDK12 IFI27 12465754 1022269 Calcitriol induces a significant G0/G1 arrest and modulates p21 ( Waf/Cip1 ) and ( Kip1 ) , the [cyclin dependent kinase] *inhibitors* . Negative_regulation CDK12 IFI27 12663518 1074567 IP6 strongly increased the expression of CDKIs ( [cyclin dependent kinase] *inhibitors* ) , Cip1/p21 and , without any noticeable changes in G1 CDKs and cyclins , except a slight increase in cyclin D2 . Negative_regulation CDK12 IFI27 12771291 1094758 Parathyroid cell growth in patients with advanced secondary hyperparathyroidism : vitamin D receptor and [cyclin dependent kinase] *inhibitors* , p21 and . Negative_regulation CDK12 IFI27 12943995 1135807 We also observed a simultaneous increase in the expression of [cyclin-dependent-kinase] *inhibitors* , p21 , , p15 and p16 , associated with a loss in expression of Cyclin-A2 and Cyclin-E . Negative_regulation CDK12 IFI27 14618613 1188027 To examine the mechanism of the troglitazone induced growth inhibition , we determined ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , expression by Western blot analysis in troglitazone treated HLF cells . Negative_regulation CDK12 IFI27 15048878 1225260 We conclude that substrate dependent acquisition of proliferative phenotypes following repeated cycles of AAM injury correlates with modulation of the [cyclin dependent kinase] *inhibitors* , and p21 . Negative_regulation CDK12 IFI27 15138205 1246194 Gastric cells chronically exposed to H pylori in vitro develop resistance to apoptosis associated with low levels of , a [cyclin dependent kinase] *inhibitor* and haplo insufficient tumour suppressor gene that is downregulated in gastric cancer . Negative_regulation CDK12 IFI27 15224009 1264898 A high level of , an *inhibitor* of [cyclin dependent kinase] that correlates with the degree of in vitro apoptosis , is found in B-CLL cells . Negative_regulation CDK12 IFI27 15263796 1275078 The prognostic significance of cyclins D1 , E and [cyclin dependent kinase] *inhibitors* p21 ( Waf1/Cip1 ) , ( Kip1 ) in determining the risk of recurrence and progression with both univariate ( log rank test ) and multivariate ( Cox regression ) methods of analysis showed no statistically significance differences . Negative_regulation CDK12 IFI27 15378017 1324025 In the present study , we investigated the consequences of the combined loss of either of two [cyclin dependent kinase] *inhibitors* , p21 and , in cooperation with deletion of the INK4a/ARF locus . Negative_regulation CDK12 IFI27 15474987 1354685 Under the same conditions , adding MG or HK to VD3 or ATRA treatment further enlarged the G0/G1 cell population and increased the expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK12 IFI27 15491288 1321379 In addition , in myeloma cells subjected to growth-factor starvation , the upregulation of PGP9.5 was observed in association with that of ( Kip1 ) , a [cyclin-dependent-kinase] *inhibitor* , although the upregulation caused by irradiation was milder . Negative_regulation CDK12 IFI27 15799773 1390567 Several genes , including insulin-like growth factor 1 (IGF-1) and [cyclin dependent kinase] *inhibitor* ( ( Kip1 ) ) were induced by both injury types and these may have potential clinical application as markers of tissue damage . Negative_regulation CDK12 IFI27 15930262 1414430 Here , we found that VDUP1-/- fibroblast cells proliferated more rapidly compared with wild-type cells with reduced expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK12 IFI27 16020508 1465828 Tregs were blocked from cell cycle progression due to decrease of cyclin E and cyclin A and increase of ( p27kip [cyclin dependent kinase] *inhibitor* ) . Negative_regulation CDK12 IFI27 16039115 1473618 Levels of expression of cyclins , cyclin dependent kinases and [cyclin dependent kinase] *inhibitors* , p21 and , were analysed by western blotting . Negative_regulation CDK12 IFI27 16328436 1503627 [Cyclin dependent kinase] *inhibitors* CIP1 ( p21 ) and KIP1 ( ) in ovarian cancer . Negative_regulation CDK12 IFI27 16427178 1567184 In this study , under treatment with various concentrations of PA in MDA-MB 231 cell line , we checked mRNA levels for cyclin A and cyclin B1 and the protein levels of cyclin A and cyclin B1 , Cdc2 ( cyclin dependent kinases ) , p21 ( waf1/cip1 ) and ( Kip1 ) ( [cyclin dependent kinase] *inhibitors* ) , Cdc25C , Chk2 and Wee1 kinase ( cyclin dependent kinase relative factors ) in cell cycle G2/M phase . Negative_regulation CDK12 IFI27 16436005 1495311 ( kip1 ) , a universal [cyclin dependent kinase] *inhibitor* , is a useful marker for predicting clinical aggressiveness with various human tumors . Negative_regulation CDK12 IFI27 16564150 1555724 In contrast , protein levels of , a [cyclin dependent kinase] *inhibitor* , are increased after induction of ER-stress using tunicamycin . Negative_regulation CDK12 IFI27 17360552 1712767 As proof of principle , we studied the consequence of sporadic loss of , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK12 IFI27 17918155 1843886 Furthermore , we find that the growth inhibitory dose of R1881 leads to increases in the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21 and as well as to G1 arrest . Negative_regulation CDK12 IFI27 17979972 1874288 Terrein was found to downregulate cyclin B1 and Cdc2 without Cdc2 phosphorylation , but upregulated ( KIP1 ) ( p27 ) , a known *inhibitor* of [cyclin dependent kinase] . Negative_regulation CDK12 IFI27 18583941 1953335 Roles of [cyclin dependent kinase] *inhibitors* , p21/Cip1 ( p21 ) and p27/Kip1 ( ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation CDK12 IFI27 19026637 2022732 Activation of ERK1/2 was not affected by MacCM , and neither was the expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK12 IFI27 19147535 2026292 Two [cyclin dependent kinase] *inhibitors* , p18 ( Ink4c ) and ( Kip1 ) , are required for proper cerebellar development . Negative_regulation CDK12 IFI27 19276255 2046197 In retrospective studies , loss of ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has been associated with poor prognosis following colorectal cancer treatment . Negative_regulation CDK12 IFI27 19321452 2073942 Although HSC70 directly bound to ( Kip1 ) ( a [cyclin dependent kinase] *inhibitor* ) , histatin 3 increased the binding between those proteins but not with a peptide capable of binding to HSC70 . Negative_regulation CDK12 IFI27 19538337 2103582 In this study , we examined the role of melatonin on synoviocyte proliferation in primary cultured human fibroblast-like synoviocytes ( FLSs ) by analyzing protein expression of P21 ( CIP1 ) ( P21 ) and ( KIP1 ) ( P27 ) , the [cyclin dependent kinase] *inhibitors* that are important in cell cycle control , and the phosphorylation of mitogen activated protein kinases ( MAPKs ) . Negative_regulation CDK12 IFI27 19598246 2149820 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is also known to demarcate the prosensory region in the cochlear primordium , which consists of the sensory progenitors that have completed their terminal mitoses . Negative_regulation CDK12 IFI27 19720293 2133713 Trastuzumab , a humanized antibody directed against the Her2 receptor , induces the expression of ( kip1 ) , an intranuclear [cyclin dependent kinase] *inhibitor* in some breast cancer cells . Negative_regulation CDK12 IFI27 21443540 2438451 Furthermore , NS expression was associated with cellular proliferation in OSCC cell lines using siRNA , which upregulated , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK12 IFI27 21980125 2502938 Further , deletion of AMPKa2 but not AMPKa1 reduced the level of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , and increased the level of S-phase kinase associated protein 2 ( Skp2 ) , a known E3 ubiquitin ligase for p27 ( Kip1 ) , through activation of p52 nuclear factor kappa B ( NF-?B ) -2 . Negative_regulation CDK12 IFI27 22154697 2563127 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) of the CIP/KIP family , p21 , and p57 , mediate cell cycle inhibition . Negative_regulation CDK12 IFI27 22460505 2637140 Cell cycle analysis indicated thioridazine induced the down-regulation of cyclin D1 , cyclin A and CDK4 , and the induction of p21 and , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK12 IFI27 22851678 2677212 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , ( Kip1 ) , and cyclin D1 . Negative_regulation CDK12 IFI27 23255047 2827363 Skp2 mediated degradation of , a [cyclin dependent kinase] *inhibitor* , is involved in cell cycle regulation . Negative_regulation CDK12 IFI27 23721824 2819720 miR-370 induced proliferation was correlated with the downregulation of [cyclin dependent kinase] *inhibitors* , ( Kip1 ) and p21 ( Cip1 ) , and the upregulation of the cell cycle regulator cyclin D1 . Negative_regulation CDK12 IFI27 23888319 2902011 Our results found that curcumin inhibited cell proliferation , which was associated with upregulation of the [cyclin dependent kinase] *inhibitors* , and p21 , and downregulation of cyclin D1 . Negative_regulation CDK12 IFI27 23944957 2887984 We determined whether proliferation and IL-6 release are abnormal in ASM cells ( ASMCs ) from patients with severe asthma , and whether these features could be mediated by microRNA-221 and microRNA-222 , through modulation of the [cyclin dependent kinase] *inhibitors* , p21 ( WAF1 ) and ( kip1 ) . Negative_regulation CDK12 IFI27 24067984 2867176 Western blot analysis of key cell cycle regulators revealed that K-Rta mediated cell cycle arrest was associated with a decrease in cyclin A and phosphorylated Rb ( pS807/pS811 ) protein levels , both markers of S phase progression , and an increase in protein levels for , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK12 IFI27 24708177 2938878 Recently , STMN1 was reported to interact with , an *inhibitor* of [cyclin dependent kinase] complexes . Negative_regulation CDK12 IFI27 8654372 366886 Expression of Zta results in induction of the tumor suppressor protein , p53 , and the [cyclin dependent kinase] *inhibitors* , p21 and , as well as accumulation of hypophosphorylated pRb . Negative_regulation CDK12 IFI27 8845296 337847 We have examined the level of cyclin E , a G1 cyclin , and , a [cyclin dependent kinase] *inhibitor* , in BALB/c 3T3 cells . Negative_regulation CDK12 IFI27 9616167 509589 The identification of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* that contributes to cell cycle arrest and represents a link between extracellular signals and cell cycle , prompted us to study p27 protein in the lymphocytes from 88 patients with B-CLL and 32 patients with other chronic B-lymphoproliferative disorders . Negative_regulation CDK12 IFI27 9746784 533003 The ( kip-1 ) , a [cyclin dependent kinase] *inhibitor* which is important in blocking the cell cycle , was induced more quickly and potently by Ro 25-9716 ( 10 ( -7 ) mol/L , 0 to 5 days ) than by 1,25D3 , suggesting a possible mechanism by which these analogs inhibit proliferation of leukemic growth . Negative_regulation CDK12 IFI27 9891946 558586 Hence , we have determined the cell cycle profile , expressions and activities of the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21CIP1 and , during rat ventricular myocyte development . Negative_regulation CDK12 ITGA9 22138449 2536221 Furthermore , effects of p21 , a [cyclin dependent kinase] *inhibitor* , and integrin a9 ( ) were examined . Negative_regulation CDK12 MAP2K6 10597223 573470 p21Cip1/Waf1 [cyclin dependent kinase] inhibitor ( p21 ) is *inducible* by Raf and ( MAPKK ) , but the level of regulation is unknown . Negative_regulation CDK12 MAP2K6 21871886 2491324 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK12 RARB 21868513 2473730 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Negative_regulation CDK13 CCND1 22851678 2677174 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , p27 ( Kip1 ) , and . Negative_regulation CDK13 CCND1 24399246 2906967 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) ( p21Cip1 , p27Kip1 , p15INK4B ) , and cyclin E were shown to be differentially expressed in latexin overexpressed cells and latexin silenced cells . Negative_regulation CDK13 CDKN1C 11347369 814325 The expression of , a [cyclin dependent kinase] *inhibitor* , is a strong indicator that the cells are exiting the cell cycle and are beginning to differentiate . Negative_regulation CDK13 CDKN1C 11529881 853600 We examine the cell proliferation activity and expression of [cyclin dependent kinase] *inhibitors* of the Cip/Kip family , p21Cip1 , p27Kip1 and , in foetal hamster lungs to determine the expression patterns of the cyclin dependent kinase inhibitors and to clarify the relationship between expression of the cyclin dependent kinase inhibitors and lung development . Negative_regulation CDK13 CDKN1C 15224347 1264946 The expression of ( Kip2 ) , a [cyclin dependent kinase] *inhibitor* that was also in the imprinted region , exhibited some variable increased expression predominantly in hepatic neoplasms from livers of female TG+ rats . Negative_regulation CDK13 CDKN1C 15537824 1367508 In contrast , EGCG accelerates terminal differentiation in normal human epidermal keratinocytes ( NHEK ) mediated partially by up-regulation of , a [cyclin dependent kinase] *inhibitor* that confers growth arrest and differentiation . Negative_regulation CDK13 CDKN1C 16731797 1565996 Differential expression of [cyclin dependent kinase] *inhibitors* , p27Kip1 and , by corticotropin in rat adrenal cortex . Negative_regulation CDK13 CDKN1C 16731797 1566034 An important role for the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p27Kip1 and , in the proliferation and differentiation of adrenal cells has been suggested by their knockout mice , which display adrenal hyperplasia . Negative_regulation CDK13 CDKN1C 18822693 1970535 The aim of this study was to establish the importance of , a unique [cyclin dependent kinase] *inhibitor* , in the oncogenesis of bladder carcinoma . Negative_regulation CDK13 CDKN1C 20503313 2263848 A small number of individuals with BWS ( 5-10 % ) have mutations in , a [cyclin dependent kinase] *inhibitor* of G1 cyclin complexes that functions as a negative regulator of cellular growth and proliferation . Negative_regulation CDK13 CDKN1C 21322636 2443293 p21 was found to be a key regulator of this process , because down-regulation of the [cyclin dependent kinase] *inhibitors* p27 ( CDKN1B/KIP1 ) or p57 ( ) or the tumor suppressor p53 ( TP53/LFS1 ) failed to induce proliferation and subsequent dedifferentiation . Negative_regulation CDK13 CDKN1C 22996691 2679048 Expression of , a BMP10 regulated [cyclin dependent kinase] *inhibitor* , was induced in Myocd-/- hearts , while BMP10 activated cardiogenic transcription factors , including NKX2.5 and MEF2c , were repressed . Negative_regulation CDK13 CDKN1C 7550351 323230 Genomic imprinting of , a [cyclin dependent kinase] *inhibitor* , in mouse . Negative_regulation CDK13 CDKN1C 7729683 302207 Cloning of , a [cyclin dependent kinase] *inhibitor* with unique domain structure and tissue distribution . Negative_regulation CDK13 CDKN1C 8923002 397201 The gene for insulin-like growth factor II (IGF2) is normally expressed from the paternal allele , while H19 and , a [cyclin dependent kinase] *inhibitor* , are expressed from the maternal allele . Negative_regulation CDK13 CDKN1C 9311734 455007 these include the gene for insulin-like growth factor II (IGF2) and H19 , which show abnormal imprint-specific expression and/or methylation in 20 % of BWS patients , and , a [cyclin dependent kinase] *inhibitor* , which we found showed biallelic expression in one of nine BWS patients studied . Negative_regulation CDK13 EPHB2 20855497 2325791 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Negative_regulation CDK13 EPHB2 21871886 2491180 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK13 IFI27 10198213 605028 73-kDa heat shock cognate protein interacts directly with , a [cyclin dependent kinase] *inhibitor* , during G1/S transition . Negative_regulation CDK13 IFI27 10198213 605066 In the present study , we demonstrated that 73hsc ( heat shock cognate protein ) , which belongs to the HSP70 family of molecular chaperones , interacts with , an *inhibitor* of [cyclin dependent kinase] , during G1/S transition . Negative_regulation CDK13 IFI27 10510349 651097 The treatment of macrophages with adenosine induces the expression of , a G1 [cyclin dependent kinase] *inhibitor* , in a protein kinase A-dependent way . Negative_regulation CDK13 IFI27 10859299 715243 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in many types of carcinomas . Negative_regulation CDK13 IFI27 10861499 705301 ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has an important role in the progression of cells from G ( 1 ) into S phase of the cell cycle . Negative_regulation CDK13 IFI27 10903892 713398 Minimal requirements for the nuclear localization of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK13 IFI27 11136238 786705 Previous work has shown that cyclin A can be cleaved at Arg-70/Arg-71 by a proteolytic activity present in an in vitro coupled transcription/translation system by using rabbit reticulocyte lysate programmed by plasmid DNA encoding ( KIP1 ) , a [cyclin dependent kinase] *inhibitor* , but not by plasmid DNAs encoding other cyclin dependent kinases inhibitors . Negative_regulation CDK13 IFI27 11164713 782651 [Cyclin dependent kinase] *inhibitors* , p21 ( waf1/cip1 ) and ( kip1 ) , are expressed site- and hair cycle-dependently in rat hair follicles . Negative_regulation CDK13 IFI27 11237531 790102 A major function of , also known as Kip1 , is to bind and *inhibit* [cyclin/cyclin dependent kinase] complexes , thereby blocking cell cycle progression . Negative_regulation CDK13 IFI27 11251953 793935 Low expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is a marker of poor prognosis in synovial sarcoma . Negative_regulation CDK13 IFI27 11251953 793954 Low expression of ( kip1 ) , a dominant [cyclin dependent kinase] *inhibitor* involved in G1-S transition of the cell cycle , recently has been reported to be associated with aggressive tumor growth . Negative_regulation CDK13 IFI27 11301477 803356 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in breast cancer . Negative_regulation CDK13 IFI27 11400230 824387 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , negatively regulates the G1 phase progression of the cell cycle by binding to the cyclin E/cyclin dependent kinase 2 complex . Negative_regulation CDK13 IFI27 11557117 861240 , a [cyclin dependent kinase] *inhibitor* , regulates the progression from G1 into the S phase by binding and inhibiting cyclin/cdks . Negative_regulation CDK13 IFI27 11744034 897885 Levels of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p16 and , were initially high in quiescent isolated cells and tissue ; Negative_regulation CDK13 IFI27 11745414 888955 Herein , expression of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p21 , and p57 and their associated kinase activities were examined in 61 cases of soft tissue smooth muscle tumors . Negative_regulation CDK13 IFI27 11850846 913174 LY294002 also causes an increase in , a [cyclin dependent kinase] *inhibitor* and results in the dephosphorylation of members of the pocket protein family . Negative_regulation CDK13 IFI27 11856766 914392 The differentiation was accompanied by a growth arrest and the upregulation of [cyclin dependent kinase] *inhibitors* , and p57 , as well as cyclin D(1) , whereas cyclin A was downregulated . Negative_regulation CDK13 IFI27 12097295 961265 Reduced expression level of , a [cyclin dependent kinase] *inhibitor* , is associated with high aggressiveness and poor prognosis of various malignant tumors , including gastric carcinoma . Negative_regulation CDK13 IFI27 12465754 1022245 Calcitriol induces a significant G0/G1 arrest and modulates p21 ( Waf/Cip1 ) and ( Kip1 ) , the [cyclin dependent kinase] *inhibitors* . Negative_regulation CDK13 IFI27 12663518 1074519 IP6 strongly increased the expression of CDKIs ( [cyclin dependent kinase] *inhibitors* ) , Cip1/p21 and , without any noticeable changes in G1 CDKs and cyclins , except a slight increase in cyclin D2 . Negative_regulation CDK13 IFI27 12771291 1094734 Parathyroid cell growth in patients with advanced secondary hyperparathyroidism : vitamin D receptor and [cyclin dependent kinase] *inhibitors* , p21 and . Negative_regulation CDK13 IFI27 12943995 1135783 We also observed a simultaneous increase in the expression of [cyclin-dependent-kinase] *inhibitors* , p21 , , p15 and p16 , associated with a loss in expression of Cyclin-A2 and Cyclin-E . Negative_regulation CDK13 IFI27 14618613 1188015 To examine the mechanism of the troglitazone induced growth inhibition , we determined ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , expression by Western blot analysis in troglitazone treated HLF cells . Negative_regulation CDK13 IFI27 15048878 1225236 We conclude that substrate dependent acquisition of proliferative phenotypes following repeated cycles of AAM injury correlates with modulation of the [cyclin dependent kinase] *inhibitors* , and p21 . Negative_regulation CDK13 IFI27 15138205 1246182 Gastric cells chronically exposed to H pylori in vitro develop resistance to apoptosis associated with low levels of , a [cyclin dependent kinase] *inhibitor* and haplo insufficient tumour suppressor gene that is downregulated in gastric cancer . Negative_regulation CDK13 IFI27 15224009 1264874 A high level of , an *inhibitor* of [cyclin dependent kinase] that correlates with the degree of in vitro apoptosis , is found in B-CLL cells . Negative_regulation CDK13 IFI27 15263796 1275066 The prognostic significance of cyclins D1 , E and [cyclin dependent kinase] *inhibitors* p21 ( Waf1/Cip1 ) , ( Kip1 ) in determining the risk of recurrence and progression with both univariate ( log rank test ) and multivariate ( Cox regression ) methods of analysis showed no statistically significance differences . Negative_regulation CDK13 IFI27 15378017 1324001 In the present study , we investigated the consequences of the combined loss of either of two [cyclin dependent kinase] *inhibitors* , p21 and , in cooperation with deletion of the INK4a/ARF locus . Negative_regulation CDK13 IFI27 15474987 1354673 Under the same conditions , adding MG or HK to VD3 or ATRA treatment further enlarged the G0/G1 cell population and increased the expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK13 IFI27 15491288 1321367 In addition , in myeloma cells subjected to growth-factor starvation , the upregulation of PGP9.5 was observed in association with that of ( Kip1 ) , a [cyclin-dependent-kinase] *inhibitor* , although the upregulation caused by irradiation was milder . Negative_regulation CDK13 IFI27 15799773 1390555 Several genes , including insulin-like growth factor 1 (IGF-1) and [cyclin dependent kinase] *inhibitor* ( ( Kip1 ) ) were induced by both injury types and these may have potential clinical application as markers of tissue damage . Negative_regulation CDK13 IFI27 15930262 1414418 Here , we found that VDUP1-/- fibroblast cells proliferated more rapidly compared with wild-type cells with reduced expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK13 IFI27 16020508 1465804 Tregs were blocked from cell cycle progression due to decrease of cyclin E and cyclin A and increase of ( p27kip [cyclin dependent kinase] *inhibitor* ) . Negative_regulation CDK13 IFI27 16039115 1473594 Levels of expression of cyclins , cyclin dependent kinases and [cyclin dependent kinase] *inhibitors* , p21 and , were analysed by western blotting . Negative_regulation CDK13 IFI27 16328436 1503615 [Cyclin dependent kinase] *inhibitors* CIP1 ( p21 ) and KIP1 ( ) in ovarian cancer . Negative_regulation CDK13 IFI27 16427178 1567160 In this study , under treatment with various concentrations of PA in MDA-MB 231 cell line , we checked mRNA levels for cyclin A and cyclin B1 and the protein levels of cyclin A and cyclin B1 , Cdc2 ( cyclin dependent kinases ) , p21 ( waf1/cip1 ) and ( Kip1 ) ( [cyclin dependent kinase] *inhibitors* ) , Cdc25C , Chk2 and Wee1 kinase ( cyclin dependent kinase relative factors ) in cell cycle G2/M phase . Negative_regulation CDK13 IFI27 16436005 1495299 ( kip1 ) , a universal [cyclin dependent kinase] *inhibitor* , is a useful marker for predicting clinical aggressiveness with various human tumors . Negative_regulation CDK13 IFI27 16564150 1555712 In contrast , protein levels of , a [cyclin dependent kinase] *inhibitor* , are increased after induction of ER-stress using tunicamycin . Negative_regulation CDK13 IFI27 17360552 1712743 As proof of principle , we studied the consequence of sporadic loss of , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK13 IFI27 17918155 1843862 Furthermore , we find that the growth inhibitory dose of R1881 leads to increases in the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21 and as well as to G1 arrest . Negative_regulation CDK13 IFI27 17979972 1874276 Terrein was found to downregulate cyclin B1 and Cdc2 without Cdc2 phosphorylation , but upregulated ( KIP1 ) ( p27 ) , a known *inhibitor* of [cyclin dependent kinase] . Negative_regulation CDK13 IFI27 18583941 1953285 Roles of [cyclin dependent kinase] *inhibitors* , p21/Cip1 ( p21 ) and p27/Kip1 ( ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation CDK13 IFI27 19026637 2022720 Activation of ERK1/2 was not affected by MacCM , and neither was the expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK13 IFI27 19147535 2026268 Two [cyclin dependent kinase] *inhibitors* , p18 ( Ink4c ) and ( Kip1 ) , are required for proper cerebellar development . Negative_regulation CDK13 IFI27 19276255 2046185 In retrospective studies , loss of ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has been associated with poor prognosis following colorectal cancer treatment . Negative_regulation CDK13 IFI27 19321452 2073930 Although HSC70 directly bound to ( Kip1 ) ( a [cyclin dependent kinase] *inhibitor* ) , histatin 3 increased the binding between those proteins but not with a peptide capable of binding to HSC70 . Negative_regulation CDK13 IFI27 19538337 2103558 In this study , we examined the role of melatonin on synoviocyte proliferation in primary cultured human fibroblast-like synoviocytes ( FLSs ) by analyzing protein expression of P21 ( CIP1 ) ( P21 ) and ( KIP1 ) ( P27 ) , the [cyclin dependent kinase] *inhibitors* that are important in cell cycle control , and the phosphorylation of mitogen activated protein kinases ( MAPKs ) . Negative_regulation CDK13 IFI27 19598246 2149808 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is also known to demarcate the prosensory region in the cochlear primordium , which consists of the sensory progenitors that have completed their terminal mitoses . Negative_regulation CDK13 IFI27 19720293 2133701 Trastuzumab , a humanized antibody directed against the Her2 receptor , induces the expression of ( kip1 ) , an intranuclear [cyclin dependent kinase] *inhibitor* in some breast cancer cells . Negative_regulation CDK13 IFI27 21443540 2438439 Furthermore , NS expression was associated with cellular proliferation in OSCC cell lines using siRNA , which upregulated , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK13 IFI27 21980125 2502926 Further , deletion of AMPKa2 but not AMPKa1 reduced the level of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , and increased the level of S-phase kinase associated protein 2 ( Skp2 ) , a known E3 ubiquitin ligase for p27 ( Kip1 ) , through activation of p52 nuclear factor kappa B ( NF-?B ) -2 . Negative_regulation CDK13 IFI27 22154697 2563115 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) of the CIP/KIP family , p21 , and p57 , mediate cell cycle inhibition . Negative_regulation CDK13 IFI27 22460505 2637116 Cell cycle analysis indicated thioridazine induced the down-regulation of cyclin D1 , cyclin A and CDK4 , and the induction of p21 and , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK13 IFI27 22851678 2677176 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , ( Kip1 ) , and cyclin D1 . Negative_regulation CDK13 IFI27 23255047 2827351 Skp2 mediated degradation of , a [cyclin dependent kinase] *inhibitor* , is involved in cell cycle regulation . Negative_regulation CDK13 IFI27 23721824 2819696 miR-370 induced proliferation was correlated with the downregulation of [cyclin dependent kinase] *inhibitors* , ( Kip1 ) and p21 ( Cip1 ) , and the upregulation of the cell cycle regulator cyclin D1 . Negative_regulation CDK13 IFI27 23888319 2901987 Our results found that curcumin inhibited cell proliferation , which was associated with upregulation of the [cyclin dependent kinase] *inhibitors* , and p21 , and downregulation of cyclin D1 . Negative_regulation CDK13 IFI27 23944957 2887960 We determined whether proliferation and IL-6 release are abnormal in ASM cells ( ASMCs ) from patients with severe asthma , and whether these features could be mediated by microRNA-221 and microRNA-222 , through modulation of the [cyclin dependent kinase] *inhibitors* , p21 ( WAF1 ) and ( kip1 ) . Negative_regulation CDK13 IFI27 24067984 2867164 Western blot analysis of key cell cycle regulators revealed that K-Rta mediated cell cycle arrest was associated with a decrease in cyclin A and phosphorylated Rb ( pS807/pS811 ) protein levels , both markers of S phase progression , and an increase in protein levels for , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK13 IFI27 24708177 2938866 Recently , STMN1 was reported to interact with , an *inhibitor* of [cyclin dependent kinase] complexes . Negative_regulation CDK13 IFI27 8654372 366862 Expression of Zta results in induction of the tumor suppressor protein , p53 , and the [cyclin dependent kinase] *inhibitors* , p21 and , as well as accumulation of hypophosphorylated pRb . Negative_regulation CDK13 IFI27 8845296 337811 We have examined the level of cyclin E , a G1 cyclin , and , a [cyclin dependent kinase] *inhibitor* , in BALB/c 3T3 cells . Negative_regulation CDK13 IFI27 9616167 509577 The identification of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* that contributes to cell cycle arrest and represents a link between extracellular signals and cell cycle , prompted us to study p27 protein in the lymphocytes from 88 patients with B-CLL and 32 patients with other chronic B-lymphoproliferative disorders . Negative_regulation CDK13 IFI27 9746784 532991 The ( kip-1 ) , a [cyclin dependent kinase] *inhibitor* which is important in blocking the cell cycle , was induced more quickly and potently by Ro 25-9716 ( 10 ( -7 ) mol/L , 0 to 5 days ) than by 1,25D3 , suggesting a possible mechanism by which these analogs inhibit proliferation of leukemic growth . Negative_regulation CDK13 IFI27 9891946 558538 Hence , we have determined the cell cycle profile , expressions and activities of the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21CIP1 and , during rat ventricular myocyte development . Negative_regulation CDK13 ITGA9 22138449 2536209 Furthermore , effects of p21 , a [cyclin dependent kinase] *inhibitor* , and integrin a9 ( ) were examined . Negative_regulation CDK13 MAP2K6 10597223 573359 p21Cip1/Waf1 [cyclin dependent kinase] inhibitor ( p21 ) is *inducible* by Raf and ( MAPKK ) , but the level of regulation is unknown . Negative_regulation CDK13 MAP2K6 21871886 2491186 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK13 RARB 21868513 2473718 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Negative_regulation CDK14 CCND1 22851678 2677222 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , p27 ( Kip1 ) , and . Negative_regulation CDK14 CCND1 24399246 2906983 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) ( p21Cip1 , p27Kip1 , p15INK4B ) , and cyclin E were shown to be differentially expressed in latexin overexpressed cells and latexin silenced cells . Negative_regulation CDK14 CDKN1C 11347369 814341 The expression of , a [cyclin dependent kinase] *inhibitor* , is a strong indicator that the cells are exiting the cell cycle and are beginning to differentiate . Negative_regulation CDK14 CDKN1C 11529881 853648 We examine the cell proliferation activity and expression of [cyclin dependent kinase] *inhibitors* of the Cip/Kip family , p21Cip1 , p27Kip1 and , in foetal hamster lungs to determine the expression patterns of the cyclin dependent kinase inhibitors and to clarify the relationship between expression of the cyclin dependent kinase inhibitors and lung development . Negative_regulation CDK14 CDKN1C 15224347 1264962 The expression of ( Kip2 ) , a [cyclin dependent kinase] *inhibitor* that was also in the imprinted region , exhibited some variable increased expression predominantly in hepatic neoplasms from livers of female TG+ rats . Negative_regulation CDK14 CDKN1C 15537824 1367524 In contrast , EGCG accelerates terminal differentiation in normal human epidermal keratinocytes ( NHEK ) mediated partially by up-regulation of , a [cyclin dependent kinase] *inhibitor* that confers growth arrest and differentiation . Negative_regulation CDK14 CDKN1C 16731797 1566028 Differential expression of [cyclin dependent kinase] *inhibitors* , p27Kip1 and , by corticotropin in rat adrenal cortex . Negative_regulation CDK14 CDKN1C 16731797 1566066 An important role for the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p27Kip1 and , in the proliferation and differentiation of adrenal cells has been suggested by their knockout mice , which display adrenal hyperplasia . Negative_regulation CDK14 CDKN1C 18822693 1970551 The aim of this study was to establish the importance of , a unique [cyclin dependent kinase] *inhibitor* , in the oncogenesis of bladder carcinoma . Negative_regulation CDK14 CDKN1C 20503313 2263865 A small number of individuals with BWS ( 5-10 % ) have mutations in , a [cyclin dependent kinase] *inhibitor* of G1 cyclin complexes that functions as a negative regulator of cellular growth and proliferation . Negative_regulation CDK14 CDKN1C 21322636 2443325 p21 was found to be a key regulator of this process , because down-regulation of the [cyclin dependent kinase] *inhibitors* p27 ( CDKN1B/KIP1 ) or p57 ( ) or the tumor suppressor p53 ( TP53/LFS1 ) failed to induce proliferation and subsequent dedifferentiation . Negative_regulation CDK14 CDKN1C 22996691 2679064 Expression of , a BMP10 regulated [cyclin dependent kinase] *inhibitor* , was induced in Myocd-/- hearts , while BMP10 activated cardiogenic transcription factors , including NKX2.5 and MEF2c , were repressed . Negative_regulation CDK14 CDKN1C 7550351 323246 Genomic imprinting of , a [cyclin dependent kinase] *inhibitor* , in mouse . Negative_regulation CDK14 CDKN1C 7729683 302223 Cloning of , a [cyclin dependent kinase] *inhibitor* with unique domain structure and tissue distribution . Negative_regulation CDK14 CDKN1C 8923002 397233 The gene for insulin-like growth factor II (IGF2) is normally expressed from the paternal allele , while H19 and , a [cyclin dependent kinase] *inhibitor* , are expressed from the maternal allele . Negative_regulation CDK14 CDKN1C 9311734 455023 these include the gene for insulin-like growth factor II (IGF2) and H19 , which show abnormal imprint-specific expression and/or methylation in 20 % of BWS patients , and , a [cyclin dependent kinase] *inhibitor* , which we found showed biallelic expression in one of nine BWS patients studied . Negative_regulation CDK14 EPHB2 20855497 2325842 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Negative_regulation CDK14 EPHB2 21871886 2491358 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK14 IFI27 10198213 605060 73-kDa heat shock cognate protein interacts directly with , a [cyclin dependent kinase] *inhibitor* , during G1/S transition . Negative_regulation CDK14 IFI27 10198213 605098 In the present study , we demonstrated that 73hsc ( heat shock cognate protein ) , which belongs to the HSP70 family of molecular chaperones , interacts with , an *inhibitor* of [cyclin dependent kinase] , during G1/S transition . Negative_regulation CDK14 IFI27 10510349 651129 The treatment of macrophages with adenosine induces the expression of , a G1 [cyclin dependent kinase] *inhibitor* , in a protein kinase A-dependent way . Negative_regulation CDK14 IFI27 10859299 715259 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in many types of carcinomas . Negative_regulation CDK14 IFI27 10861499 705317 ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has an important role in the progression of cells from G ( 1 ) into S phase of the cell cycle . Negative_regulation CDK14 IFI27 10903892 713414 Minimal requirements for the nuclear localization of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK14 IFI27 11136238 786721 Previous work has shown that cyclin A can be cleaved at Arg-70/Arg-71 by a proteolytic activity present in an in vitro coupled transcription/translation system by using rabbit reticulocyte lysate programmed by plasmid DNA encoding ( KIP1 ) , a [cyclin dependent kinase] *inhibitor* , but not by plasmid DNAs encoding other cyclin dependent kinases inhibitors . Negative_regulation CDK14 IFI27 11164713 782683 [Cyclin dependent kinase] *inhibitors* , p21 ( waf1/cip1 ) and ( kip1 ) , are expressed site- and hair cycle-dependently in rat hair follicles . Negative_regulation CDK14 IFI27 11237531 790119 A major function of , also known as Kip1 , is to bind and *inhibit* [cyclin/cyclin dependent kinase] complexes , thereby blocking cell cycle progression . Negative_regulation CDK14 IFI27 11251953 793951 Low expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is a marker of poor prognosis in synovial sarcoma . Negative_regulation CDK14 IFI27 11251953 793970 Low expression of ( kip1 ) , a dominant [cyclin dependent kinase] *inhibitor* involved in G1-S transition of the cell cycle , recently has been reported to be associated with aggressive tumor growth . Negative_regulation CDK14 IFI27 11301477 803372 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in breast cancer . Negative_regulation CDK14 IFI27 11400230 824403 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , negatively regulates the G1 phase progression of the cell cycle by binding to the cyclin E/cyclin dependent kinase 2 complex . Negative_regulation CDK14 IFI27 11557117 861256 , a [cyclin dependent kinase] *inhibitor* , regulates the progression from G1 into the S phase by binding and inhibiting cyclin/cdks . Negative_regulation CDK14 IFI27 11744034 897901 Levels of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p16 and , were initially high in quiescent isolated cells and tissue ; Negative_regulation CDK14 IFI27 11745414 888971 Herein , expression of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p21 , and p57 and their associated kinase activities were examined in 61 cases of soft tissue smooth muscle tumors . Negative_regulation CDK14 IFI27 11850846 913206 LY294002 also causes an increase in , a [cyclin dependent kinase] *inhibitor* and results in the dephosphorylation of members of the pocket protein family . Negative_regulation CDK14 IFI27 11856766 914408 The differentiation was accompanied by a growth arrest and the upregulation of [cyclin dependent kinase] *inhibitors* , and p57 , as well as cyclin D(1) , whereas cyclin A was downregulated . Negative_regulation CDK14 IFI27 12097295 961281 Reduced expression level of , a [cyclin dependent kinase] *inhibitor* , is associated with high aggressiveness and poor prognosis of various malignant tumors , including gastric carcinoma . Negative_regulation CDK14 IFI27 12465754 1022277 Calcitriol induces a significant G0/G1 arrest and modulates p21 ( Waf/Cip1 ) and ( Kip1 ) , the [cyclin dependent kinase] *inhibitors* . Negative_regulation CDK14 IFI27 12663518 1074583 IP6 strongly increased the expression of CDKIs ( [cyclin dependent kinase] *inhibitors* ) , Cip1/p21 and , without any noticeable changes in G1 CDKs and cyclins , except a slight increase in cyclin D2 . Negative_regulation CDK14 IFI27 12771291 1094766 Parathyroid cell growth in patients with advanced secondary hyperparathyroidism : vitamin D receptor and [cyclin dependent kinase] *inhibitors* , p21 and . Negative_regulation CDK14 IFI27 12943995 1135815 We also observed a simultaneous increase in the expression of [cyclin-dependent-kinase] *inhibitors* , p21 , , p15 and p16 , associated with a loss in expression of Cyclin-A2 and Cyclin-E . Negative_regulation CDK14 IFI27 14618613 1188031 To examine the mechanism of the troglitazone induced growth inhibition , we determined ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , expression by Western blot analysis in troglitazone treated HLF cells . Negative_regulation CDK14 IFI27 15048878 1225268 We conclude that substrate dependent acquisition of proliferative phenotypes following repeated cycles of AAM injury correlates with modulation of the [cyclin dependent kinase] *inhibitors* , and p21 . Negative_regulation CDK14 IFI27 15138205 1246198 Gastric cells chronically exposed to H pylori in vitro develop resistance to apoptosis associated with low levels of , a [cyclin dependent kinase] *inhibitor* and haplo insufficient tumour suppressor gene that is downregulated in gastric cancer . Negative_regulation CDK14 IFI27 15224009 1264906 A high level of , an *inhibitor* of [cyclin dependent kinase] that correlates with the degree of in vitro apoptosis , is found in B-CLL cells . Negative_regulation CDK14 IFI27 15263796 1275082 The prognostic significance of cyclins D1 , E and [cyclin dependent kinase] *inhibitors* p21 ( Waf1/Cip1 ) , ( Kip1 ) in determining the risk of recurrence and progression with both univariate ( log rank test ) and multivariate ( Cox regression ) methods of analysis showed no statistically significance differences . Negative_regulation CDK14 IFI27 15378017 1324033 In the present study , we investigated the consequences of the combined loss of either of two [cyclin dependent kinase] *inhibitors* , p21 and , in cooperation with deletion of the INK4a/ARF locus . Negative_regulation CDK14 IFI27 15474987 1354689 Under the same conditions , adding MG or HK to VD3 or ATRA treatment further enlarged the G0/G1 cell population and increased the expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK14 IFI27 15491288 1321383 In addition , in myeloma cells subjected to growth-factor starvation , the upregulation of PGP9.5 was observed in association with that of ( Kip1 ) , a [cyclin-dependent-kinase] *inhibitor* , although the upregulation caused by irradiation was milder . Negative_regulation CDK14 IFI27 15799773 1390572 Several genes , including insulin-like growth factor 1 (IGF-1) and [cyclin dependent kinase] *inhibitor* ( ( Kip1 ) ) were induced by both injury types and these may have potential clinical application as markers of tissue damage . Negative_regulation CDK14 IFI27 15930262 1414434 Here , we found that VDUP1-/- fibroblast cells proliferated more rapidly compared with wild-type cells with reduced expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK14 IFI27 16020508 1465838 Tregs were blocked from cell cycle progression due to decrease of cyclin E and cyclin A and increase of ( p27kip [cyclin dependent kinase] *inhibitor* ) . Negative_regulation CDK14 IFI27 16039115 1473626 Levels of expression of cyclins , cyclin dependent kinases and [cyclin dependent kinase] *inhibitors* , p21 and , were analysed by western blotting . Negative_regulation CDK14 IFI27 16328436 1503631 [Cyclin dependent kinase] *inhibitors* CIP1 ( p21 ) and KIP1 ( ) in ovarian cancer . Negative_regulation CDK14 IFI27 16427178 1567192 In this study , under treatment with various concentrations of PA in MDA-MB 231 cell line , we checked mRNA levels for cyclin A and cyclin B1 and the protein levels of cyclin A and cyclin B1 , Cdc2 ( cyclin dependent kinases ) , p21 ( waf1/cip1 ) and ( Kip1 ) ( [cyclin dependent kinase] *inhibitors* ) , Cdc25C , Chk2 and Wee1 kinase ( cyclin dependent kinase relative factors ) in cell cycle G2/M phase . Negative_regulation CDK14 IFI27 16436005 1495315 ( kip1 ) , a universal [cyclin dependent kinase] *inhibitor* , is a useful marker for predicting clinical aggressiveness with various human tumors . Negative_regulation CDK14 IFI27 16564150 1555728 In contrast , protein levels of , a [cyclin dependent kinase] *inhibitor* , are increased after induction of ER-stress using tunicamycin . Negative_regulation CDK14 IFI27 17360552 1712775 As proof of principle , we studied the consequence of sporadic loss of , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK14 IFI27 17918155 1843894 Furthermore , we find that the growth inhibitory dose of R1881 leads to increases in the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21 and as well as to G1 arrest . Negative_regulation CDK14 IFI27 17979972 1874292 Terrein was found to downregulate cyclin B1 and Cdc2 without Cdc2 phosphorylation , but upregulated ( KIP1 ) ( p27 ) , a known *inhibitor* of [cyclin dependent kinase] . Negative_regulation CDK14 IFI27 18583941 1953355 Roles of [cyclin dependent kinase] *inhibitors* , p21/Cip1 ( p21 ) and p27/Kip1 ( ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation CDK14 IFI27 19026637 2022736 Activation of ERK1/2 was not affected by MacCM , and neither was the expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK14 IFI27 19147535 2026300 Two [cyclin dependent kinase] *inhibitors* , p18 ( Ink4c ) and ( Kip1 ) , are required for proper cerebellar development . Negative_regulation CDK14 IFI27 19276255 2046201 In retrospective studies , loss of ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has been associated with poor prognosis following colorectal cancer treatment . Negative_regulation CDK14 IFI27 19321452 2073946 Although HSC70 directly bound to ( Kip1 ) ( a [cyclin dependent kinase] *inhibitor* ) , histatin 3 increased the binding between those proteins but not with a peptide capable of binding to HSC70 . Negative_regulation CDK14 IFI27 19538337 2103590 In this study , we examined the role of melatonin on synoviocyte proliferation in primary cultured human fibroblast-like synoviocytes ( FLSs ) by analyzing protein expression of P21 ( CIP1 ) ( P21 ) and ( KIP1 ) ( P27 ) , the [cyclin dependent kinase] *inhibitors* that are important in cell cycle control , and the phosphorylation of mitogen activated protein kinases ( MAPKs ) . Negative_regulation CDK14 IFI27 19598246 2149824 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is also known to demarcate the prosensory region in the cochlear primordium , which consists of the sensory progenitors that have completed their terminal mitoses . Negative_regulation CDK14 IFI27 19720293 2133717 Trastuzumab , a humanized antibody directed against the Her2 receptor , induces the expression of ( kip1 ) , an intranuclear [cyclin dependent kinase] *inhibitor* in some breast cancer cells . Negative_regulation CDK14 IFI27 21443540 2438455 Furthermore , NS expression was associated with cellular proliferation in OSCC cell lines using siRNA , which upregulated , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK14 IFI27 21980125 2502942 Further , deletion of AMPKa2 but not AMPKa1 reduced the level of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , and increased the level of S-phase kinase associated protein 2 ( Skp2 ) , a known E3 ubiquitin ligase for p27 ( Kip1 ) , through activation of p52 nuclear factor kappa B ( NF-?B ) -2 . Negative_regulation CDK14 IFI27 22154697 2563131 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) of the CIP/KIP family , p21 , and p57 , mediate cell cycle inhibition . Negative_regulation CDK14 IFI27 22460505 2637148 Cell cycle analysis indicated thioridazine induced the down-regulation of cyclin D1 , cyclin A and CDK4 , and the induction of p21 and , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK14 IFI27 22851678 2677224 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , ( Kip1 ) , and cyclin D1 . Negative_regulation CDK14 IFI27 23255047 2827367 Skp2 mediated degradation of , a [cyclin dependent kinase] *inhibitor* , is involved in cell cycle regulation . Negative_regulation CDK14 IFI27 23721824 2819728 miR-370 induced proliferation was correlated with the downregulation of [cyclin dependent kinase] *inhibitors* , ( Kip1 ) and p21 ( Cip1 ) , and the upregulation of the cell cycle regulator cyclin D1 . Negative_regulation CDK14 IFI27 23888319 2902019 Our results found that curcumin inhibited cell proliferation , which was associated with upregulation of the [cyclin dependent kinase] *inhibitors* , and p21 , and downregulation of cyclin D1 . Negative_regulation CDK14 IFI27 23944957 2887992 We determined whether proliferation and IL-6 release are abnormal in ASM cells ( ASMCs ) from patients with severe asthma , and whether these features could be mediated by microRNA-221 and microRNA-222 , through modulation of the [cyclin dependent kinase] *inhibitors* , p21 ( WAF1 ) and ( kip1 ) . Negative_regulation CDK14 IFI27 24067984 2867180 Western blot analysis of key cell cycle regulators revealed that K-Rta mediated cell cycle arrest was associated with a decrease in cyclin A and phosphorylated Rb ( pS807/pS811 ) protein levels , both markers of S phase progression , and an increase in protein levels for , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK14 IFI27 24708177 2938882 Recently , STMN1 was reported to interact with , an *inhibitor* of [cyclin dependent kinase] complexes . Negative_regulation CDK14 IFI27 8654372 366896 Expression of Zta results in induction of the tumor suppressor protein , p53 , and the [cyclin dependent kinase] *inhibitors* , p21 and , as well as accumulation of hypophosphorylated pRb . Negative_regulation CDK14 IFI27 8845296 337859 We have examined the level of cyclin E , a G1 cyclin , and , a [cyclin dependent kinase] *inhibitor* , in BALB/c 3T3 cells . Negative_regulation CDK14 IFI27 9616167 509593 The identification of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* that contributes to cell cycle arrest and represents a link between extracellular signals and cell cycle , prompted us to study p27 protein in the lymphocytes from 88 patients with B-CLL and 32 patients with other chronic B-lymphoproliferative disorders . Negative_regulation CDK14 IFI27 9746784 533007 The ( kip-1 ) , a [cyclin dependent kinase] *inhibitor* which is important in blocking the cell cycle , was induced more quickly and potently by Ro 25-9716 ( 10 ( -7 ) mol/L , 0 to 5 days ) than by 1,25D3 , suggesting a possible mechanism by which these analogs inhibit proliferation of leukemic growth . Negative_regulation CDK14 IFI27 9891946 558602 Hence , we have determined the cell cycle profile , expressions and activities of the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21CIP1 and , during rat ventricular myocyte development . Negative_regulation CDK14 ITGA9 22138449 2536225 Furthermore , effects of p21 , a [cyclin dependent kinase] *inhibitor* , and integrin a9 ( ) were examined . Negative_regulation CDK14 MAP2K6 10597223 573502 p21Cip1/Waf1 [cyclin dependent kinase] inhibitor ( p21 ) is *inducible* by Raf and ( MAPKK ) , but the level of regulation is unknown . Negative_regulation CDK14 MAP2K6 21871886 2491364 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK14 RARB 21868513 2473734 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Negative_regulation CDK15 CCND1 22851678 2677168 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , p27 ( Kip1 ) , and . Negative_regulation CDK15 CCND1 24399246 2906965 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) ( p21Cip1 , p27Kip1 , p15INK4B ) , and cyclin E were shown to be differentially expressed in latexin overexpressed cells and latexin silenced cells . Negative_regulation CDK15 CDKN1C 11347369 814323 The expression of , a [cyclin dependent kinase] *inhibitor* , is a strong indicator that the cells are exiting the cell cycle and are beginning to differentiate . Negative_regulation CDK15 CDKN1C 11529881 853594 We examine the cell proliferation activity and expression of [cyclin dependent kinase] *inhibitors* of the Cip/Kip family , p21Cip1 , p27Kip1 and , in foetal hamster lungs to determine the expression patterns of the cyclin dependent kinase inhibitors and to clarify the relationship between expression of the cyclin dependent kinase inhibitors and lung development . Negative_regulation CDK15 CDKN1C 15224347 1264944 The expression of ( Kip2 ) , a [cyclin dependent kinase] *inhibitor* that was also in the imprinted region , exhibited some variable increased expression predominantly in hepatic neoplasms from livers of female TG+ rats . Negative_regulation CDK15 CDKN1C 15537824 1367506 In contrast , EGCG accelerates terminal differentiation in normal human epidermal keratinocytes ( NHEK ) mediated partially by up-regulation of , a [cyclin dependent kinase] *inhibitor* that confers growth arrest and differentiation . Negative_regulation CDK15 CDKN1C 16731797 1565992 Differential expression of [cyclin dependent kinase] *inhibitors* , p27Kip1 and , by corticotropin in rat adrenal cortex . Negative_regulation CDK15 CDKN1C 16731797 1566030 An important role for the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p27Kip1 and , in the proliferation and differentiation of adrenal cells has been suggested by their knockout mice , which display adrenal hyperplasia . Negative_regulation CDK15 CDKN1C 18822693 1970533 The aim of this study was to establish the importance of , a unique [cyclin dependent kinase] *inhibitor* , in the oncogenesis of bladder carcinoma . Negative_regulation CDK15 CDKN1C 20503313 2263846 A small number of individuals with BWS ( 5-10 % ) have mutations in , a [cyclin dependent kinase] *inhibitor* of G1 cyclin complexes that functions as a negative regulator of cellular growth and proliferation . Negative_regulation CDK15 CDKN1C 21322636 2443289 p21 was found to be a key regulator of this process , because down-regulation of the [cyclin dependent kinase] *inhibitors* p27 ( CDKN1B/KIP1 ) or p57 ( ) or the tumor suppressor p53 ( TP53/LFS1 ) failed to induce proliferation and subsequent dedifferentiation . Negative_regulation CDK15 CDKN1C 22996691 2679046 Expression of , a BMP10 regulated [cyclin dependent kinase] *inhibitor* , was induced in Myocd-/- hearts , while BMP10 activated cardiogenic transcription factors , including NKX2.5 and MEF2c , were repressed . Negative_regulation CDK15 CDKN1C 7550351 323228 Genomic imprinting of , a [cyclin dependent kinase] *inhibitor* , in mouse . Negative_regulation CDK15 CDKN1C 7729683 302205 Cloning of , a [cyclin dependent kinase] *inhibitor* with unique domain structure and tissue distribution . Negative_regulation CDK15 CDKN1C 8923002 397197 The gene for insulin-like growth factor II (IGF2) is normally expressed from the paternal allele , while H19 and , a [cyclin dependent kinase] *inhibitor* , are expressed from the maternal allele . Negative_regulation CDK15 CDKN1C 9311734 455005 these include the gene for insulin-like growth factor II (IGF2) and H19 , which show abnormal imprint-specific expression and/or methylation in 20 % of BWS patients , and , a [cyclin dependent kinase] *inhibitor* , which we found showed biallelic expression in one of nine BWS patients studied . Negative_regulation CDK15 EPHB2 20855497 2325785 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Negative_regulation CDK15 EPHB2 21871886 2491160 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK15 IFI27 10198213 605024 73-kDa heat shock cognate protein interacts directly with , a [cyclin dependent kinase] *inhibitor* , during G1/S transition . Negative_regulation CDK15 IFI27 10198213 605062 In the present study , we demonstrated that 73hsc ( heat shock cognate protein ) , which belongs to the HSP70 family of molecular chaperones , interacts with , an *inhibitor* of [cyclin dependent kinase] , during G1/S transition . Negative_regulation CDK15 IFI27 10510349 651093 The treatment of macrophages with adenosine induces the expression of , a G1 [cyclin dependent kinase] *inhibitor* , in a protein kinase A-dependent way . Negative_regulation CDK15 IFI27 10859299 715241 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in many types of carcinomas . Negative_regulation CDK15 IFI27 10861499 705299 ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has an important role in the progression of cells from G ( 1 ) into S phase of the cell cycle . Negative_regulation CDK15 IFI27 10903892 713396 Minimal requirements for the nuclear localization of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK15 IFI27 11136238 786703 Previous work has shown that cyclin A can be cleaved at Arg-70/Arg-71 by a proteolytic activity present in an in vitro coupled transcription/translation system by using rabbit reticulocyte lysate programmed by plasmid DNA encoding ( KIP1 ) , a [cyclin dependent kinase] *inhibitor* , but not by plasmid DNAs encoding other cyclin dependent kinases inhibitors . Negative_regulation CDK15 IFI27 11164713 782647 [Cyclin dependent kinase] *inhibitors* , p21 ( waf1/cip1 ) and ( kip1 ) , are expressed site- and hair cycle-dependently in rat hair follicles . Negative_regulation CDK15 IFI27 11237531 790100 A major function of , also known as Kip1 , is to bind and *inhibit* [cyclin/cyclin dependent kinase] complexes , thereby blocking cell cycle progression . Negative_regulation CDK15 IFI27 11251953 793933 Low expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is a marker of poor prognosis in synovial sarcoma . Negative_regulation CDK15 IFI27 11251953 793952 Low expression of ( kip1 ) , a dominant [cyclin dependent kinase] *inhibitor* involved in G1-S transition of the cell cycle , recently has been reported to be associated with aggressive tumor growth . Negative_regulation CDK15 IFI27 11301477 803354 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in breast cancer . Negative_regulation CDK15 IFI27 11400230 824385 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , negatively regulates the G1 phase progression of the cell cycle by binding to the cyclin E/cyclin dependent kinase 2 complex . Negative_regulation CDK15 IFI27 11557117 861238 , a [cyclin dependent kinase] *inhibitor* , regulates the progression from G1 into the S phase by binding and inhibiting cyclin/cdks . Negative_regulation CDK15 IFI27 11744034 897883 Levels of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p16 and , were initially high in quiescent isolated cells and tissue ; Negative_regulation CDK15 IFI27 11745414 888953 Herein , expression of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p21 , and p57 and their associated kinase activities were examined in 61 cases of soft tissue smooth muscle tumors . Negative_regulation CDK15 IFI27 11850846 913170 LY294002 also causes an increase in , a [cyclin dependent kinase] *inhibitor* and results in the dephosphorylation of members of the pocket protein family . Negative_regulation CDK15 IFI27 11856766 914390 The differentiation was accompanied by a growth arrest and the upregulation of [cyclin dependent kinase] *inhibitors* , and p57 , as well as cyclin D(1) , whereas cyclin A was downregulated . Negative_regulation CDK15 IFI27 12097295 961263 Reduced expression level of , a [cyclin dependent kinase] *inhibitor* , is associated with high aggressiveness and poor prognosis of various malignant tumors , including gastric carcinoma . Negative_regulation CDK15 IFI27 12465754 1022241 Calcitriol induces a significant G0/G1 arrest and modulates p21 ( Waf/Cip1 ) and ( Kip1 ) , the [cyclin dependent kinase] *inhibitors* . Negative_regulation CDK15 IFI27 12663518 1074511 IP6 strongly increased the expression of CDKIs ( [cyclin dependent kinase] *inhibitors* ) , Cip1/p21 and , without any noticeable changes in G1 CDKs and cyclins , except a slight increase in cyclin D2 . Negative_regulation CDK15 IFI27 12771291 1094730 Parathyroid cell growth in patients with advanced secondary hyperparathyroidism : vitamin D receptor and [cyclin dependent kinase] *inhibitors* , p21 and . Negative_regulation CDK15 IFI27 12943995 1135779 We also observed a simultaneous increase in the expression of [cyclin-dependent-kinase] *inhibitors* , p21 , , p15 and p16 , associated with a loss in expression of Cyclin-A2 and Cyclin-E . Negative_regulation CDK15 IFI27 14618613 1188013 To examine the mechanism of the troglitazone induced growth inhibition , we determined ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , expression by Western blot analysis in troglitazone treated HLF cells . Negative_regulation CDK15 IFI27 15048878 1225232 We conclude that substrate dependent acquisition of proliferative phenotypes following repeated cycles of AAM injury correlates with modulation of the [cyclin dependent kinase] *inhibitors* , and p21 . Negative_regulation CDK15 IFI27 15138205 1246180 Gastric cells chronically exposed to H pylori in vitro develop resistance to apoptosis associated with low levels of , a [cyclin dependent kinase] *inhibitor* and haplo insufficient tumour suppressor gene that is downregulated in gastric cancer . Negative_regulation CDK15 IFI27 15224009 1264870 A high level of , an *inhibitor* of [cyclin dependent kinase] that correlates with the degree of in vitro apoptosis , is found in B-CLL cells . Negative_regulation CDK15 IFI27 15263796 1275064 The prognostic significance of cyclins D1 , E and [cyclin dependent kinase] *inhibitors* p21 ( Waf1/Cip1 ) , ( Kip1 ) in determining the risk of recurrence and progression with both univariate ( log rank test ) and multivariate ( Cox regression ) methods of analysis showed no statistically significance differences . Negative_regulation CDK15 IFI27 15378017 1323997 In the present study , we investigated the consequences of the combined loss of either of two [cyclin dependent kinase] *inhibitors* , p21 and , in cooperation with deletion of the INK4a/ARF locus . Negative_regulation CDK15 IFI27 15474987 1354671 Under the same conditions , adding MG or HK to VD3 or ATRA treatment further enlarged the G0/G1 cell population and increased the expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK15 IFI27 15491288 1321365 In addition , in myeloma cells subjected to growth-factor starvation , the upregulation of PGP9.5 was observed in association with that of ( Kip1 ) , a [cyclin-dependent-kinase] *inhibitor* , although the upregulation caused by irradiation was milder . Negative_regulation CDK15 IFI27 15799773 1390553 Several genes , including insulin-like growth factor 1 (IGF-1) and [cyclin dependent kinase] *inhibitor* ( ( Kip1 ) ) were induced by both injury types and these may have potential clinical application as markers of tissue damage . Negative_regulation CDK15 IFI27 15930262 1414416 Here , we found that VDUP1-/- fibroblast cells proliferated more rapidly compared with wild-type cells with reduced expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK15 IFI27 16020508 1465799 Tregs were blocked from cell cycle progression due to decrease of cyclin E and cyclin A and increase of ( p27kip [cyclin dependent kinase] *inhibitor* ) . Negative_regulation CDK15 IFI27 16039115 1473590 Levels of expression of cyclins , cyclin dependent kinases and [cyclin dependent kinase] *inhibitors* , p21 and , were analysed by western blotting . Negative_regulation CDK15 IFI27 16328436 1503613 [Cyclin dependent kinase] *inhibitors* CIP1 ( p21 ) and KIP1 ( ) in ovarian cancer . Negative_regulation CDK15 IFI27 16427178 1567156 In this study , under treatment with various concentrations of PA in MDA-MB 231 cell line , we checked mRNA levels for cyclin A and cyclin B1 and the protein levels of cyclin A and cyclin B1 , Cdc2 ( cyclin dependent kinases ) , p21 ( waf1/cip1 ) and ( Kip1 ) ( [cyclin dependent kinase] *inhibitors* ) , Cdc25C , Chk2 and Wee1 kinase ( cyclin dependent kinase relative factors ) in cell cycle G2/M phase . Negative_regulation CDK15 IFI27 16436005 1495297 ( kip1 ) , a universal [cyclin dependent kinase] *inhibitor* , is a useful marker for predicting clinical aggressiveness with various human tumors . Negative_regulation CDK15 IFI27 16564150 1555710 In contrast , protein levels of , a [cyclin dependent kinase] *inhibitor* , are increased after induction of ER-stress using tunicamycin . Negative_regulation CDK15 IFI27 17360552 1712739 As proof of principle , we studied the consequence of sporadic loss of , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK15 IFI27 17918155 1843858 Furthermore , we find that the growth inhibitory dose of R1881 leads to increases in the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21 and as well as to G1 arrest . Negative_regulation CDK15 IFI27 17979972 1874274 Terrein was found to downregulate cyclin B1 and Cdc2 without Cdc2 phosphorylation , but upregulated ( KIP1 ) ( p27 ) , a known *inhibitor* of [cyclin dependent kinase] . Negative_regulation CDK15 IFI27 18583941 1953277 Roles of [cyclin dependent kinase] *inhibitors* , p21/Cip1 ( p21 ) and p27/Kip1 ( ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation CDK15 IFI27 19026637 2022718 Activation of ERK1/2 was not affected by MacCM , and neither was the expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK15 IFI27 19147535 2026264 Two [cyclin dependent kinase] *inhibitors* , p18 ( Ink4c ) and ( Kip1 ) , are required for proper cerebellar development . Negative_regulation CDK15 IFI27 19276255 2046183 In retrospective studies , loss of ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has been associated with poor prognosis following colorectal cancer treatment . Negative_regulation CDK15 IFI27 19321452 2073928 Although HSC70 directly bound to ( Kip1 ) ( a [cyclin dependent kinase] *inhibitor* ) , histatin 3 increased the binding between those proteins but not with a peptide capable of binding to HSC70 . Negative_regulation CDK15 IFI27 19538337 2103554 In this study , we examined the role of melatonin on synoviocyte proliferation in primary cultured human fibroblast-like synoviocytes ( FLSs ) by analyzing protein expression of P21 ( CIP1 ) ( P21 ) and ( KIP1 ) ( P27 ) , the [cyclin dependent kinase] *inhibitors* that are important in cell cycle control , and the phosphorylation of mitogen activated protein kinases ( MAPKs ) . Negative_regulation CDK15 IFI27 19598246 2149806 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is also known to demarcate the prosensory region in the cochlear primordium , which consists of the sensory progenitors that have completed their terminal mitoses . Negative_regulation CDK15 IFI27 19720293 2133699 Trastuzumab , a humanized antibody directed against the Her2 receptor , induces the expression of ( kip1 ) , an intranuclear [cyclin dependent kinase] *inhibitor* in some breast cancer cells . Negative_regulation CDK15 IFI27 21443540 2438437 Furthermore , NS expression was associated with cellular proliferation in OSCC cell lines using siRNA , which upregulated , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK15 IFI27 21980125 2502924 Further , deletion of AMPKa2 but not AMPKa1 reduced the level of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , and increased the level of S-phase kinase associated protein 2 ( Skp2 ) , a known E3 ubiquitin ligase for p27 ( Kip1 ) , through activation of p52 nuclear factor kappa B ( NF-?B ) -2 . Negative_regulation CDK15 IFI27 22154697 2563113 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) of the CIP/KIP family , p21 , and p57 , mediate cell cycle inhibition . Negative_regulation CDK15 IFI27 22460505 2637112 Cell cycle analysis indicated thioridazine induced the down-regulation of cyclin D1 , cyclin A and CDK4 , and the induction of p21 and , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK15 IFI27 22851678 2677170 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , ( Kip1 ) , and cyclin D1 . Negative_regulation CDK15 IFI27 23255047 2827349 Skp2 mediated degradation of , a [cyclin dependent kinase] *inhibitor* , is involved in cell cycle regulation . Negative_regulation CDK15 IFI27 23721824 2819692 miR-370 induced proliferation was correlated with the downregulation of [cyclin dependent kinase] *inhibitors* , ( Kip1 ) and p21 ( Cip1 ) , and the upregulation of the cell cycle regulator cyclin D1 . Negative_regulation CDK15 IFI27 23888319 2901983 Our results found that curcumin inhibited cell proliferation , which was associated with upregulation of the [cyclin dependent kinase] *inhibitors* , and p21 , and downregulation of cyclin D1 . Negative_regulation CDK15 IFI27 23944957 2887956 We determined whether proliferation and IL-6 release are abnormal in ASM cells ( ASMCs ) from patients with severe asthma , and whether these features could be mediated by microRNA-221 and microRNA-222 , through modulation of the [cyclin dependent kinase] *inhibitors* , p21 ( WAF1 ) and ( kip1 ) . Negative_regulation CDK15 IFI27 24067984 2867162 Western blot analysis of key cell cycle regulators revealed that K-Rta mediated cell cycle arrest was associated with a decrease in cyclin A and phosphorylated Rb ( pS807/pS811 ) protein levels , both markers of S phase progression , and an increase in protein levels for , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK15 IFI27 24708177 2938864 Recently , STMN1 was reported to interact with , an *inhibitor* of [cyclin dependent kinase] complexes . Negative_regulation CDK15 IFI27 8654372 366858 Expression of Zta results in induction of the tumor suppressor protein , p53 , and the [cyclin dependent kinase] *inhibitors* , p21 and , as well as accumulation of hypophosphorylated pRb . Negative_regulation CDK15 IFI27 8845296 337805 We have examined the level of cyclin E , a G1 cyclin , and , a [cyclin dependent kinase] *inhibitor* , in BALB/c 3T3 cells . Negative_regulation CDK15 IFI27 9616167 509575 The identification of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* that contributes to cell cycle arrest and represents a link between extracellular signals and cell cycle , prompted us to study p27 protein in the lymphocytes from 88 patients with B-CLL and 32 patients with other chronic B-lymphoproliferative disorders . Negative_regulation CDK15 IFI27 9746784 532989 The ( kip-1 ) , a [cyclin dependent kinase] *inhibitor* which is important in blocking the cell cycle , was induced more quickly and potently by Ro 25-9716 ( 10 ( -7 ) mol/L , 0 to 5 days ) than by 1,25D3 , suggesting a possible mechanism by which these analogs inhibit proliferation of leukemic growth . Negative_regulation CDK15 IFI27 9891946 558530 Hence , we have determined the cell cycle profile , expressions and activities of the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21CIP1 and , during rat ventricular myocyte development . Negative_regulation CDK15 ITGA9 22138449 2536207 Furthermore , effects of p21 , a [cyclin dependent kinase] *inhibitor* , and integrin a9 ( ) were examined . Negative_regulation CDK15 MAP2K6 10597223 573343 p21Cip1/Waf1 [cyclin dependent kinase] inhibitor ( p21 ) is *inducible* by Raf and ( MAPKK ) , but the level of regulation is unknown . Negative_regulation CDK15 MAP2K6 21871886 2491166 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK15 RARB 21868513 2473716 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Negative_regulation CDK16 CCND1 22851678 2677213 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , p27 ( Kip1 ) , and . Negative_regulation CDK16 CCND1 24399246 2906980 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) ( p21Cip1 , p27Kip1 , p15INK4B ) , and cyclin E were shown to be differentially expressed in latexin overexpressed cells and latexin silenced cells . Negative_regulation CDK16 CDKN1C 11347369 814338 The expression of , a [cyclin dependent kinase] *inhibitor* , is a strong indicator that the cells are exiting the cell cycle and are beginning to differentiate . Negative_regulation CDK16 CDKN1C 11529881 853639 We examine the cell proliferation activity and expression of [cyclin dependent kinase] *inhibitors* of the Cip/Kip family , p21Cip1 , p27Kip1 and , in foetal hamster lungs to determine the expression patterns of the cyclin dependent kinase inhibitors and to clarify the relationship between expression of the cyclin dependent kinase inhibitors and lung development . Negative_regulation CDK16 CDKN1C 15224347 1264959 The expression of ( Kip2 ) , a [cyclin dependent kinase] *inhibitor* that was also in the imprinted region , exhibited some variable increased expression predominantly in hepatic neoplasms from livers of female TG+ rats . Negative_regulation CDK16 CDKN1C 15537824 1367521 In contrast , EGCG accelerates terminal differentiation in normal human epidermal keratinocytes ( NHEK ) mediated partially by up-regulation of , a [cyclin dependent kinase] *inhibitor* that confers growth arrest and differentiation . Negative_regulation CDK16 CDKN1C 16731797 1566022 Differential expression of [cyclin dependent kinase] *inhibitors* , p27Kip1 and , by corticotropin in rat adrenal cortex . Negative_regulation CDK16 CDKN1C 16731797 1566060 An important role for the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p27Kip1 and , in the proliferation and differentiation of adrenal cells has been suggested by their knockout mice , which display adrenal hyperplasia . Negative_regulation CDK16 CDKN1C 18822693 1970548 The aim of this study was to establish the importance of , a unique [cyclin dependent kinase] *inhibitor* , in the oncogenesis of bladder carcinoma . Negative_regulation CDK16 CDKN1C 20503313 2263862 A small number of individuals with BWS ( 5-10 % ) have mutations in , a [cyclin dependent kinase] *inhibitor* of G1 cyclin complexes that functions as a negative regulator of cellular growth and proliferation . Negative_regulation CDK16 CDKN1C 21322636 2443319 p21 was found to be a key regulator of this process , because down-regulation of the [cyclin dependent kinase] *inhibitors* p27 ( CDKN1B/KIP1 ) or p57 ( ) or the tumor suppressor p53 ( TP53/LFS1 ) failed to induce proliferation and subsequent dedifferentiation . Negative_regulation CDK16 CDKN1C 22996691 2679061 Expression of , a BMP10 regulated [cyclin dependent kinase] *inhibitor* , was induced in Myocd-/- hearts , while BMP10 activated cardiogenic transcription factors , including NKX2.5 and MEF2c , were repressed . Negative_regulation CDK16 CDKN1C 7550351 323243 Genomic imprinting of , a [cyclin dependent kinase] *inhibitor* , in mouse . Negative_regulation CDK16 CDKN1C 7729683 302220 Cloning of , a [cyclin dependent kinase] *inhibitor* with unique domain structure and tissue distribution . Negative_regulation CDK16 CDKN1C 8923002 397227 The gene for insulin-like growth factor II (IGF2) is normally expressed from the paternal allele , while H19 and , a [cyclin dependent kinase] *inhibitor* , are expressed from the maternal allele . Negative_regulation CDK16 CDKN1C 9311734 455020 these include the gene for insulin-like growth factor II (IGF2) and H19 , which show abnormal imprint-specific expression and/or methylation in 20 % of BWS patients , and , a [cyclin dependent kinase] *inhibitor* , which we found showed biallelic expression in one of nine BWS patients studied . Negative_regulation CDK16 EPHB2 20855497 2325833 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Negative_regulation CDK16 EPHB2 21871886 2491328 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK16 IFI27 10198213 605054 73-kDa heat shock cognate protein interacts directly with , a [cyclin dependent kinase] *inhibitor* , during G1/S transition . Negative_regulation CDK16 IFI27 10198213 605092 In the present study , we demonstrated that 73hsc ( heat shock cognate protein ) , which belongs to the HSP70 family of molecular chaperones , interacts with , an *inhibitor* of [cyclin dependent kinase] , during G1/S transition . Negative_regulation CDK16 IFI27 10510349 651123 The treatment of macrophages with adenosine induces the expression of , a G1 [cyclin dependent kinase] *inhibitor* , in a protein kinase A-dependent way . Negative_regulation CDK16 IFI27 10859299 715256 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in many types of carcinomas . Negative_regulation CDK16 IFI27 10861499 705314 ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has an important role in the progression of cells from G ( 1 ) into S phase of the cell cycle . Negative_regulation CDK16 IFI27 10903892 713411 Minimal requirements for the nuclear localization of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK16 IFI27 11136238 786718 Previous work has shown that cyclin A can be cleaved at Arg-70/Arg-71 by a proteolytic activity present in an in vitro coupled transcription/translation system by using rabbit reticulocyte lysate programmed by plasmid DNA encoding ( KIP1 ) , a [cyclin dependent kinase] *inhibitor* , but not by plasmid DNAs encoding other cyclin dependent kinases inhibitors . Negative_regulation CDK16 IFI27 11164713 782677 [Cyclin dependent kinase] *inhibitors* , p21 ( waf1/cip1 ) and ( kip1 ) , are expressed site- and hair cycle-dependently in rat hair follicles . Negative_regulation CDK16 IFI27 11237531 790116 A major function of , also known as Kip1 , is to bind and *inhibit* [cyclin/cyclin dependent kinase] complexes , thereby blocking cell cycle progression . Negative_regulation CDK16 IFI27 11251953 793948 Low expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is a marker of poor prognosis in synovial sarcoma . Negative_regulation CDK16 IFI27 11251953 793967 Low expression of ( kip1 ) , a dominant [cyclin dependent kinase] *inhibitor* involved in G1-S transition of the cell cycle , recently has been reported to be associated with aggressive tumor growth . Negative_regulation CDK16 IFI27 11301477 803369 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in breast cancer . Negative_regulation CDK16 IFI27 11400230 824400 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , negatively regulates the G1 phase progression of the cell cycle by binding to the cyclin E/cyclin dependent kinase 2 complex . Negative_regulation CDK16 IFI27 11557117 861253 , a [cyclin dependent kinase] *inhibitor* , regulates the progression from G1 into the S phase by binding and inhibiting cyclin/cdks . Negative_regulation CDK16 IFI27 11744034 897898 Levels of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p16 and , were initially high in quiescent isolated cells and tissue ; Negative_regulation CDK16 IFI27 11745414 888968 Herein , expression of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p21 , and p57 and their associated kinase activities were examined in 61 cases of soft tissue smooth muscle tumors . Negative_regulation CDK16 IFI27 11850846 913200 LY294002 also causes an increase in , a [cyclin dependent kinase] *inhibitor* and results in the dephosphorylation of members of the pocket protein family . Negative_regulation CDK16 IFI27 11856766 914405 The differentiation was accompanied by a growth arrest and the upregulation of [cyclin dependent kinase] *inhibitors* , and p57 , as well as cyclin D(1) , whereas cyclin A was downregulated . Negative_regulation CDK16 IFI27 12097295 961278 Reduced expression level of , a [cyclin dependent kinase] *inhibitor* , is associated with high aggressiveness and poor prognosis of various malignant tumors , including gastric carcinoma . Negative_regulation CDK16 IFI27 12465754 1022271 Calcitriol induces a significant G0/G1 arrest and modulates p21 ( Waf/Cip1 ) and ( Kip1 ) , the [cyclin dependent kinase] *inhibitors* . Negative_regulation CDK16 IFI27 12663518 1074571 IP6 strongly increased the expression of CDKIs ( [cyclin dependent kinase] *inhibitors* ) , Cip1/p21 and , without any noticeable changes in G1 CDKs and cyclins , except a slight increase in cyclin D2 . Negative_regulation CDK16 IFI27 12771291 1094760 Parathyroid cell growth in patients with advanced secondary hyperparathyroidism : vitamin D receptor and [cyclin dependent kinase] *inhibitors* , p21 and . Negative_regulation CDK16 IFI27 12943995 1135809 We also observed a simultaneous increase in the expression of [cyclin-dependent-kinase] *inhibitors* , p21 , , p15 and p16 , associated with a loss in expression of Cyclin-A2 and Cyclin-E . Negative_regulation CDK16 IFI27 14618613 1188028 To examine the mechanism of the troglitazone induced growth inhibition , we determined ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , expression by Western blot analysis in troglitazone treated HLF cells . Negative_regulation CDK16 IFI27 15048878 1225262 We conclude that substrate dependent acquisition of proliferative phenotypes following repeated cycles of AAM injury correlates with modulation of the [cyclin dependent kinase] *inhibitors* , and p21 . Negative_regulation CDK16 IFI27 15138205 1246195 Gastric cells chronically exposed to H pylori in vitro develop resistance to apoptosis associated with low levels of , a [cyclin dependent kinase] *inhibitor* and haplo insufficient tumour suppressor gene that is downregulated in gastric cancer . Negative_regulation CDK16 IFI27 15224009 1264900 A high level of , an *inhibitor* of [cyclin dependent kinase] that correlates with the degree of in vitro apoptosis , is found in B-CLL cells . Negative_regulation CDK16 IFI27 15263796 1275079 The prognostic significance of cyclins D1 , E and [cyclin dependent kinase] *inhibitors* p21 ( Waf1/Cip1 ) , ( Kip1 ) in determining the risk of recurrence and progression with both univariate ( log rank test ) and multivariate ( Cox regression ) methods of analysis showed no statistically significance differences . Negative_regulation CDK16 IFI27 15378017 1324027 In the present study , we investigated the consequences of the combined loss of either of two [cyclin dependent kinase] *inhibitors* , p21 and , in cooperation with deletion of the INK4a/ARF locus . Negative_regulation CDK16 IFI27 15474987 1354686 Under the same conditions , adding MG or HK to VD3 or ATRA treatment further enlarged the G0/G1 cell population and increased the expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK16 IFI27 15491288 1321380 In addition , in myeloma cells subjected to growth-factor starvation , the upregulation of PGP9.5 was observed in association with that of ( Kip1 ) , a [cyclin-dependent-kinase] *inhibitor* , although the upregulation caused by irradiation was milder . Negative_regulation CDK16 IFI27 15799773 1390569 Several genes , including insulin-like growth factor 1 (IGF-1) and [cyclin dependent kinase] *inhibitor* ( ( Kip1 ) ) were induced by both injury types and these may have potential clinical application as markers of tissue damage . Negative_regulation CDK16 IFI27 15930262 1414431 Here , we found that VDUP1-/- fibroblast cells proliferated more rapidly compared with wild-type cells with reduced expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK16 IFI27 16020508 1465832 Tregs were blocked from cell cycle progression due to decrease of cyclin E and cyclin A and increase of ( p27kip [cyclin dependent kinase] *inhibitor* ) . Negative_regulation CDK16 IFI27 16039115 1473620 Levels of expression of cyclins , cyclin dependent kinases and [cyclin dependent kinase] *inhibitors* , p21 and , were analysed by western blotting . Negative_regulation CDK16 IFI27 16328436 1503628 [Cyclin dependent kinase] *inhibitors* CIP1 ( p21 ) and KIP1 ( ) in ovarian cancer . Negative_regulation CDK16 IFI27 16427178 1567186 In this study , under treatment with various concentrations of PA in MDA-MB 231 cell line , we checked mRNA levels for cyclin A and cyclin B1 and the protein levels of cyclin A and cyclin B1 , Cdc2 ( cyclin dependent kinases ) , p21 ( waf1/cip1 ) and ( Kip1 ) ( [cyclin dependent kinase] *inhibitors* ) , Cdc25C , Chk2 and Wee1 kinase ( cyclin dependent kinase relative factors ) in cell cycle G2/M phase . Negative_regulation CDK16 IFI27 16436005 1495312 ( kip1 ) , a universal [cyclin dependent kinase] *inhibitor* , is a useful marker for predicting clinical aggressiveness with various human tumors . Negative_regulation CDK16 IFI27 16564150 1555725 In contrast , protein levels of , a [cyclin dependent kinase] *inhibitor* , are increased after induction of ER-stress using tunicamycin . Negative_regulation CDK16 IFI27 17360552 1712769 As proof of principle , we studied the consequence of sporadic loss of , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK16 IFI27 17918155 1843888 Furthermore , we find that the growth inhibitory dose of R1881 leads to increases in the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21 and as well as to G1 arrest . Negative_regulation CDK16 IFI27 17979972 1874289 Terrein was found to downregulate cyclin B1 and Cdc2 without Cdc2 phosphorylation , but upregulated ( KIP1 ) ( p27 ) , a known *inhibitor* of [cyclin dependent kinase] . Negative_regulation CDK16 IFI27 18583941 1953343 Roles of [cyclin dependent kinase] *inhibitors* , p21/Cip1 ( p21 ) and p27/Kip1 ( ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation CDK16 IFI27 19026637 2022733 Activation of ERK1/2 was not affected by MacCM , and neither was the expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK16 IFI27 19147535 2026294 Two [cyclin dependent kinase] *inhibitors* , p18 ( Ink4c ) and ( Kip1 ) , are required for proper cerebellar development . Negative_regulation CDK16 IFI27 19276255 2046198 In retrospective studies , loss of ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has been associated with poor prognosis following colorectal cancer treatment . Negative_regulation CDK16 IFI27 19321452 2073943 Although HSC70 directly bound to ( Kip1 ) ( a [cyclin dependent kinase] *inhibitor* ) , histatin 3 increased the binding between those proteins but not with a peptide capable of binding to HSC70 . Negative_regulation CDK16 IFI27 19538337 2103584 In this study , we examined the role of melatonin on synoviocyte proliferation in primary cultured human fibroblast-like synoviocytes ( FLSs ) by analyzing protein expression of P21 ( CIP1 ) ( P21 ) and ( KIP1 ) ( P27 ) , the [cyclin dependent kinase] *inhibitors* that are important in cell cycle control , and the phosphorylation of mitogen activated protein kinases ( MAPKs ) . Negative_regulation CDK16 IFI27 19598246 2149821 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is also known to demarcate the prosensory region in the cochlear primordium , which consists of the sensory progenitors that have completed their terminal mitoses . Negative_regulation CDK16 IFI27 19720293 2133714 Trastuzumab , a humanized antibody directed against the Her2 receptor , induces the expression of ( kip1 ) , an intranuclear [cyclin dependent kinase] *inhibitor* in some breast cancer cells . Negative_regulation CDK16 IFI27 21443540 2438452 Furthermore , NS expression was associated with cellular proliferation in OSCC cell lines using siRNA , which upregulated , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK16 IFI27 21980125 2502939 Further , deletion of AMPKa2 but not AMPKa1 reduced the level of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , and increased the level of S-phase kinase associated protein 2 ( Skp2 ) , a known E3 ubiquitin ligase for p27 ( Kip1 ) , through activation of p52 nuclear factor kappa B ( NF-?B ) -2 . Negative_regulation CDK16 IFI27 22154697 2563128 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) of the CIP/KIP family , p21 , and p57 , mediate cell cycle inhibition . Negative_regulation CDK16 IFI27 22460505 2637142 Cell cycle analysis indicated thioridazine induced the down-regulation of cyclin D1 , cyclin A and CDK4 , and the induction of p21 and , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK16 IFI27 22851678 2677215 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , ( Kip1 ) , and cyclin D1 . Negative_regulation CDK16 IFI27 23255047 2827364 Skp2 mediated degradation of , a [cyclin dependent kinase] *inhibitor* , is involved in cell cycle regulation . Negative_regulation CDK16 IFI27 23721824 2819722 miR-370 induced proliferation was correlated with the downregulation of [cyclin dependent kinase] *inhibitors* , ( Kip1 ) and p21 ( Cip1 ) , and the upregulation of the cell cycle regulator cyclin D1 . Negative_regulation CDK16 IFI27 23888319 2902013 Our results found that curcumin inhibited cell proliferation , which was associated with upregulation of the [cyclin dependent kinase] *inhibitors* , and p21 , and downregulation of cyclin D1 . Negative_regulation CDK16 IFI27 23944957 2887986 We determined whether proliferation and IL-6 release are abnormal in ASM cells ( ASMCs ) from patients with severe asthma , and whether these features could be mediated by microRNA-221 and microRNA-222 , through modulation of the [cyclin dependent kinase] *inhibitors* , p21 ( WAF1 ) and ( kip1 ) . Negative_regulation CDK16 IFI27 24067984 2867177 Western blot analysis of key cell cycle regulators revealed that K-Rta mediated cell cycle arrest was associated with a decrease in cyclin A and phosphorylated Rb ( pS807/pS811 ) protein levels , both markers of S phase progression , and an increase in protein levels for , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK16 IFI27 24708177 2938879 Recently , STMN1 was reported to interact with , an *inhibitor* of [cyclin dependent kinase] complexes . Negative_regulation CDK16 IFI27 8654372 366890 Expression of Zta results in induction of the tumor suppressor protein , p53 , and the [cyclin dependent kinase] *inhibitors* , p21 and , as well as accumulation of hypophosphorylated pRb . Negative_regulation CDK16 IFI27 8845296 337850 We have examined the level of cyclin E , a G1 cyclin , and , a [cyclin dependent kinase] *inhibitor* , in BALB/c 3T3 cells . Negative_regulation CDK16 IFI27 9616167 509590 The identification of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* that contributes to cell cycle arrest and represents a link between extracellular signals and cell cycle , prompted us to study p27 protein in the lymphocytes from 88 patients with B-CLL and 32 patients with other chronic B-lymphoproliferative disorders . Negative_regulation CDK16 IFI27 9746784 533004 The ( kip-1 ) , a [cyclin dependent kinase] *inhibitor* which is important in blocking the cell cycle , was induced more quickly and potently by Ro 25-9716 ( 10 ( -7 ) mol/L , 0 to 5 days ) than by 1,25D3 , suggesting a possible mechanism by which these analogs inhibit proliferation of leukemic growth . Negative_regulation CDK16 IFI27 9891946 558590 Hence , we have determined the cell cycle profile , expressions and activities of the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21CIP1 and , during rat ventricular myocyte development . Negative_regulation CDK16 ITGA9 22138449 2536222 Furthermore , effects of p21 , a [cyclin dependent kinase] *inhibitor* , and integrin a9 ( ) were examined . Negative_regulation CDK16 MAP2K6 10597223 573478 p21Cip1/Waf1 [cyclin dependent kinase] inhibitor ( p21 ) is *inducible* by Raf and ( MAPKK ) , but the level of regulation is unknown . Negative_regulation CDK16 MAP2K6 21871886 2491334 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK16 RARB 21868513 2473731 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Negative_regulation CDK17 CCND1 22851678 2677216 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , p27 ( Kip1 ) , and . Negative_regulation CDK17 CCND1 24399246 2906981 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) ( p21Cip1 , p27Kip1 , p15INK4B ) , and cyclin E were shown to be differentially expressed in latexin overexpressed cells and latexin silenced cells . Negative_regulation CDK17 CDKN1C 11347369 814339 The expression of , a [cyclin dependent kinase] *inhibitor* , is a strong indicator that the cells are exiting the cell cycle and are beginning to differentiate . Negative_regulation CDK17 CDKN1C 11529881 853642 We examine the cell proliferation activity and expression of [cyclin dependent kinase] *inhibitors* of the Cip/Kip family , p21Cip1 , p27Kip1 and , in foetal hamster lungs to determine the expression patterns of the cyclin dependent kinase inhibitors and to clarify the relationship between expression of the cyclin dependent kinase inhibitors and lung development . Negative_regulation CDK17 CDKN1C 15224347 1264960 The expression of ( Kip2 ) , a [cyclin dependent kinase] *inhibitor* that was also in the imprinted region , exhibited some variable increased expression predominantly in hepatic neoplasms from livers of female TG+ rats . Negative_regulation CDK17 CDKN1C 15537824 1367522 In contrast , EGCG accelerates terminal differentiation in normal human epidermal keratinocytes ( NHEK ) mediated partially by up-regulation of , a [cyclin dependent kinase] *inhibitor* that confers growth arrest and differentiation . Negative_regulation CDK17 CDKN1C 16731797 1566024 Differential expression of [cyclin dependent kinase] *inhibitors* , p27Kip1 and , by corticotropin in rat adrenal cortex . Negative_regulation CDK17 CDKN1C 16731797 1566062 An important role for the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p27Kip1 and , in the proliferation and differentiation of adrenal cells has been suggested by their knockout mice , which display adrenal hyperplasia . Negative_regulation CDK17 CDKN1C 18822693 1970549 The aim of this study was to establish the importance of , a unique [cyclin dependent kinase] *inhibitor* , in the oncogenesis of bladder carcinoma . Negative_regulation CDK17 CDKN1C 20503313 2263863 A small number of individuals with BWS ( 5-10 % ) have mutations in , a [cyclin dependent kinase] *inhibitor* of G1 cyclin complexes that functions as a negative regulator of cellular growth and proliferation . Negative_regulation CDK17 CDKN1C 21322636 2443321 p21 was found to be a key regulator of this process , because down-regulation of the [cyclin dependent kinase] *inhibitors* p27 ( CDKN1B/KIP1 ) or p57 ( ) or the tumor suppressor p53 ( TP53/LFS1 ) failed to induce proliferation and subsequent dedifferentiation . Negative_regulation CDK17 CDKN1C 22996691 2679062 Expression of , a BMP10 regulated [cyclin dependent kinase] *inhibitor* , was induced in Myocd-/- hearts , while BMP10 activated cardiogenic transcription factors , including NKX2.5 and MEF2c , were repressed . Negative_regulation CDK17 CDKN1C 7550351 323244 Genomic imprinting of , a [cyclin dependent kinase] *inhibitor* , in mouse . Negative_regulation CDK17 CDKN1C 7729683 302221 Cloning of , a [cyclin dependent kinase] *inhibitor* with unique domain structure and tissue distribution . Negative_regulation CDK17 CDKN1C 8923002 397229 The gene for insulin-like growth factor II (IGF2) is normally expressed from the paternal allele , while H19 and , a [cyclin dependent kinase] *inhibitor* , are expressed from the maternal allele . Negative_regulation CDK17 CDKN1C 9311734 455021 these include the gene for insulin-like growth factor II (IGF2) and H19 , which show abnormal imprint-specific expression and/or methylation in 20 % of BWS patients , and , a [cyclin dependent kinase] *inhibitor* , which we found showed biallelic expression in one of nine BWS patients studied . Negative_regulation CDK17 EPHB2 20855497 2325836 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Negative_regulation CDK17 EPHB2 21871886 2491338 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK17 IFI27 10198213 605056 73-kDa heat shock cognate protein interacts directly with , a [cyclin dependent kinase] *inhibitor* , during G1/S transition . Negative_regulation CDK17 IFI27 10198213 605094 In the present study , we demonstrated that 73hsc ( heat shock cognate protein ) , which belongs to the HSP70 family of molecular chaperones , interacts with , an *inhibitor* of [cyclin dependent kinase] , during G1/S transition . Negative_regulation CDK17 IFI27 10510349 651125 The treatment of macrophages with adenosine induces the expression of , a G1 [cyclin dependent kinase] *inhibitor* , in a protein kinase A-dependent way . Negative_regulation CDK17 IFI27 10859299 715257 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in many types of carcinomas . Negative_regulation CDK17 IFI27 10861499 705315 ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has an important role in the progression of cells from G ( 1 ) into S phase of the cell cycle . Negative_regulation CDK17 IFI27 10903892 713412 Minimal requirements for the nuclear localization of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK17 IFI27 11136238 786719 Previous work has shown that cyclin A can be cleaved at Arg-70/Arg-71 by a proteolytic activity present in an in vitro coupled transcription/translation system by using rabbit reticulocyte lysate programmed by plasmid DNA encoding ( KIP1 ) , a [cyclin dependent kinase] *inhibitor* , but not by plasmid DNAs encoding other cyclin dependent kinases inhibitors . Negative_regulation CDK17 IFI27 11164713 782679 [Cyclin dependent kinase] *inhibitors* , p21 ( waf1/cip1 ) and ( kip1 ) , are expressed site- and hair cycle-dependently in rat hair follicles . Negative_regulation CDK17 IFI27 11237531 790117 A major function of , also known as Kip1 , is to bind and *inhibit* [cyclin/cyclin dependent kinase] complexes , thereby blocking cell cycle progression . Negative_regulation CDK17 IFI27 11251953 793949 Low expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is a marker of poor prognosis in synovial sarcoma . Negative_regulation CDK17 IFI27 11251953 793968 Low expression of ( kip1 ) , a dominant [cyclin dependent kinase] *inhibitor* involved in G1-S transition of the cell cycle , recently has been reported to be associated with aggressive tumor growth . Negative_regulation CDK17 IFI27 11301477 803370 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in breast cancer . Negative_regulation CDK17 IFI27 11400230 824401 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , negatively regulates the G1 phase progression of the cell cycle by binding to the cyclin E/cyclin dependent kinase 2 complex . Negative_regulation CDK17 IFI27 11557117 861254 , a [cyclin dependent kinase] *inhibitor* , regulates the progression from G1 into the S phase by binding and inhibiting cyclin/cdks . Negative_regulation CDK17 IFI27 11744034 897899 Levels of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p16 and , were initially high in quiescent isolated cells and tissue ; Negative_regulation CDK17 IFI27 11745414 888969 Herein , expression of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p21 , and p57 and their associated kinase activities were examined in 61 cases of soft tissue smooth muscle tumors . Negative_regulation CDK17 IFI27 11850846 913202 LY294002 also causes an increase in , a [cyclin dependent kinase] *inhibitor* and results in the dephosphorylation of members of the pocket protein family . Negative_regulation CDK17 IFI27 11856766 914406 The differentiation was accompanied by a growth arrest and the upregulation of [cyclin dependent kinase] *inhibitors* , and p57 , as well as cyclin D(1) , whereas cyclin A was downregulated . Negative_regulation CDK17 IFI27 12097295 961279 Reduced expression level of , a [cyclin dependent kinase] *inhibitor* , is associated with high aggressiveness and poor prognosis of various malignant tumors , including gastric carcinoma . Negative_regulation CDK17 IFI27 12465754 1022273 Calcitriol induces a significant G0/G1 arrest and modulates p21 ( Waf/Cip1 ) and ( Kip1 ) , the [cyclin dependent kinase] *inhibitors* . Negative_regulation CDK17 IFI27 12663518 1074575 IP6 strongly increased the expression of CDKIs ( [cyclin dependent kinase] *inhibitors* ) , Cip1/p21 and , without any noticeable changes in G1 CDKs and cyclins , except a slight increase in cyclin D2 . Negative_regulation CDK17 IFI27 12771291 1094762 Parathyroid cell growth in patients with advanced secondary hyperparathyroidism : vitamin D receptor and [cyclin dependent kinase] *inhibitors* , p21 and . Negative_regulation CDK17 IFI27 12943995 1135811 We also observed a simultaneous increase in the expression of [cyclin-dependent-kinase] *inhibitors* , p21 , , p15 and p16 , associated with a loss in expression of Cyclin-A2 and Cyclin-E . Negative_regulation CDK17 IFI27 14618613 1188029 To examine the mechanism of the troglitazone induced growth inhibition , we determined ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , expression by Western blot analysis in troglitazone treated HLF cells . Negative_regulation CDK17 IFI27 15048878 1225264 We conclude that substrate dependent acquisition of proliferative phenotypes following repeated cycles of AAM injury correlates with modulation of the [cyclin dependent kinase] *inhibitors* , and p21 . Negative_regulation CDK17 IFI27 15138205 1246196 Gastric cells chronically exposed to H pylori in vitro develop resistance to apoptosis associated with low levels of , a [cyclin dependent kinase] *inhibitor* and haplo insufficient tumour suppressor gene that is downregulated in gastric cancer . Negative_regulation CDK17 IFI27 15224009 1264902 A high level of , an *inhibitor* of [cyclin dependent kinase] that correlates with the degree of in vitro apoptosis , is found in B-CLL cells . Negative_regulation CDK17 IFI27 15263796 1275080 The prognostic significance of cyclins D1 , E and [cyclin dependent kinase] *inhibitors* p21 ( Waf1/Cip1 ) , ( Kip1 ) in determining the risk of recurrence and progression with both univariate ( log rank test ) and multivariate ( Cox regression ) methods of analysis showed no statistically significance differences . Negative_regulation CDK17 IFI27 15378017 1324029 In the present study , we investigated the consequences of the combined loss of either of two [cyclin dependent kinase] *inhibitors* , p21 and , in cooperation with deletion of the INK4a/ARF locus . Negative_regulation CDK17 IFI27 15474987 1354687 Under the same conditions , adding MG or HK to VD3 or ATRA treatment further enlarged the G0/G1 cell population and increased the expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK17 IFI27 15491288 1321381 In addition , in myeloma cells subjected to growth-factor starvation , the upregulation of PGP9.5 was observed in association with that of ( Kip1 ) , a [cyclin-dependent-kinase] *inhibitor* , although the upregulation caused by irradiation was milder . Negative_regulation CDK17 IFI27 15799773 1390570 Several genes , including insulin-like growth factor 1 (IGF-1) and [cyclin dependent kinase] *inhibitor* ( ( Kip1 ) ) were induced by both injury types and these may have potential clinical application as markers of tissue damage . Negative_regulation CDK17 IFI27 15930262 1414432 Here , we found that VDUP1-/- fibroblast cells proliferated more rapidly compared with wild-type cells with reduced expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK17 IFI27 16020508 1465834 Tregs were blocked from cell cycle progression due to decrease of cyclin E and cyclin A and increase of ( p27kip [cyclin dependent kinase] *inhibitor* ) . Negative_regulation CDK17 IFI27 16039115 1473622 Levels of expression of cyclins , cyclin dependent kinases and [cyclin dependent kinase] *inhibitors* , p21 and , were analysed by western blotting . Negative_regulation CDK17 IFI27 16328436 1503629 [Cyclin dependent kinase] *inhibitors* CIP1 ( p21 ) and KIP1 ( ) in ovarian cancer . Negative_regulation CDK17 IFI27 16427178 1567188 In this study , under treatment with various concentrations of PA in MDA-MB 231 cell line , we checked mRNA levels for cyclin A and cyclin B1 and the protein levels of cyclin A and cyclin B1 , Cdc2 ( cyclin dependent kinases ) , p21 ( waf1/cip1 ) and ( Kip1 ) ( [cyclin dependent kinase] *inhibitors* ) , Cdc25C , Chk2 and Wee1 kinase ( cyclin dependent kinase relative factors ) in cell cycle G2/M phase . Negative_regulation CDK17 IFI27 16436005 1495313 ( kip1 ) , a universal [cyclin dependent kinase] *inhibitor* , is a useful marker for predicting clinical aggressiveness with various human tumors . Negative_regulation CDK17 IFI27 16564150 1555726 In contrast , protein levels of , a [cyclin dependent kinase] *inhibitor* , are increased after induction of ER-stress using tunicamycin . Negative_regulation CDK17 IFI27 17360552 1712771 As proof of principle , we studied the consequence of sporadic loss of , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK17 IFI27 17918155 1843890 Furthermore , we find that the growth inhibitory dose of R1881 leads to increases in the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21 and as well as to G1 arrest . Negative_regulation CDK17 IFI27 17979972 1874290 Terrein was found to downregulate cyclin B1 and Cdc2 without Cdc2 phosphorylation , but upregulated ( KIP1 ) ( p27 ) , a known *inhibitor* of [cyclin dependent kinase] . Negative_regulation CDK17 IFI27 18583941 1953347 Roles of [cyclin dependent kinase] *inhibitors* , p21/Cip1 ( p21 ) and p27/Kip1 ( ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation CDK17 IFI27 19026637 2022734 Activation of ERK1/2 was not affected by MacCM , and neither was the expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK17 IFI27 19147535 2026296 Two [cyclin dependent kinase] *inhibitors* , p18 ( Ink4c ) and ( Kip1 ) , are required for proper cerebellar development . Negative_regulation CDK17 IFI27 19276255 2046199 In retrospective studies , loss of ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has been associated with poor prognosis following colorectal cancer treatment . Negative_regulation CDK17 IFI27 19321452 2073944 Although HSC70 directly bound to ( Kip1 ) ( a [cyclin dependent kinase] *inhibitor* ) , histatin 3 increased the binding between those proteins but not with a peptide capable of binding to HSC70 . Negative_regulation CDK17 IFI27 19538337 2103586 In this study , we examined the role of melatonin on synoviocyte proliferation in primary cultured human fibroblast-like synoviocytes ( FLSs ) by analyzing protein expression of P21 ( CIP1 ) ( P21 ) and ( KIP1 ) ( P27 ) , the [cyclin dependent kinase] *inhibitors* that are important in cell cycle control , and the phosphorylation of mitogen activated protein kinases ( MAPKs ) . Negative_regulation CDK17 IFI27 19598246 2149822 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is also known to demarcate the prosensory region in the cochlear primordium , which consists of the sensory progenitors that have completed their terminal mitoses . Negative_regulation CDK17 IFI27 19720293 2133715 Trastuzumab , a humanized antibody directed against the Her2 receptor , induces the expression of ( kip1 ) , an intranuclear [cyclin dependent kinase] *inhibitor* in some breast cancer cells . Negative_regulation CDK17 IFI27 21443540 2438453 Furthermore , NS expression was associated with cellular proliferation in OSCC cell lines using siRNA , which upregulated , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK17 IFI27 21980125 2502940 Further , deletion of AMPKa2 but not AMPKa1 reduced the level of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , and increased the level of S-phase kinase associated protein 2 ( Skp2 ) , a known E3 ubiquitin ligase for p27 ( Kip1 ) , through activation of p52 nuclear factor kappa B ( NF-?B ) -2 . Negative_regulation CDK17 IFI27 22154697 2563129 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) of the CIP/KIP family , p21 , and p57 , mediate cell cycle inhibition . Negative_regulation CDK17 IFI27 22460505 2637144 Cell cycle analysis indicated thioridazine induced the down-regulation of cyclin D1 , cyclin A and CDK4 , and the induction of p21 and , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK17 IFI27 22851678 2677218 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , ( Kip1 ) , and cyclin D1 . Negative_regulation CDK17 IFI27 23255047 2827365 Skp2 mediated degradation of , a [cyclin dependent kinase] *inhibitor* , is involved in cell cycle regulation . Negative_regulation CDK17 IFI27 23721824 2819724 miR-370 induced proliferation was correlated with the downregulation of [cyclin dependent kinase] *inhibitors* , ( Kip1 ) and p21 ( Cip1 ) , and the upregulation of the cell cycle regulator cyclin D1 . Negative_regulation CDK17 IFI27 23888319 2902015 Our results found that curcumin inhibited cell proliferation , which was associated with upregulation of the [cyclin dependent kinase] *inhibitors* , and p21 , and downregulation of cyclin D1 . Negative_regulation CDK17 IFI27 23944957 2887988 We determined whether proliferation and IL-6 release are abnormal in ASM cells ( ASMCs ) from patients with severe asthma , and whether these features could be mediated by microRNA-221 and microRNA-222 , through modulation of the [cyclin dependent kinase] *inhibitors* , p21 ( WAF1 ) and ( kip1 ) . Negative_regulation CDK17 IFI27 24067984 2867178 Western blot analysis of key cell cycle regulators revealed that K-Rta mediated cell cycle arrest was associated with a decrease in cyclin A and phosphorylated Rb ( pS807/pS811 ) protein levels , both markers of S phase progression , and an increase in protein levels for , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK17 IFI27 24708177 2938880 Recently , STMN1 was reported to interact with , an *inhibitor* of [cyclin dependent kinase] complexes . Negative_regulation CDK17 IFI27 8654372 366892 Expression of Zta results in induction of the tumor suppressor protein , p53 , and the [cyclin dependent kinase] *inhibitors* , p21 and , as well as accumulation of hypophosphorylated pRb . Negative_regulation CDK17 IFI27 8845296 337853 We have examined the level of cyclin E , a G1 cyclin , and , a [cyclin dependent kinase] *inhibitor* , in BALB/c 3T3 cells . Negative_regulation CDK17 IFI27 9616167 509591 The identification of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* that contributes to cell cycle arrest and represents a link between extracellular signals and cell cycle , prompted us to study p27 protein in the lymphocytes from 88 patients with B-CLL and 32 patients with other chronic B-lymphoproliferative disorders . Negative_regulation CDK17 IFI27 9746784 533005 The ( kip-1 ) , a [cyclin dependent kinase] *inhibitor* which is important in blocking the cell cycle , was induced more quickly and potently by Ro 25-9716 ( 10 ( -7 ) mol/L , 0 to 5 days ) than by 1,25D3 , suggesting a possible mechanism by which these analogs inhibit proliferation of leukemic growth . Negative_regulation CDK17 IFI27 9891946 558594 Hence , we have determined the cell cycle profile , expressions and activities of the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21CIP1 and , during rat ventricular myocyte development . Negative_regulation CDK17 ITGA9 22138449 2536223 Furthermore , effects of p21 , a [cyclin dependent kinase] *inhibitor* , and integrin a9 ( ) were examined . Negative_regulation CDK17 MAP2K6 10597223 573486 p21Cip1/Waf1 [cyclin dependent kinase] inhibitor ( p21 ) is *inducible* by Raf and ( MAPKK ) , but the level of regulation is unknown . Negative_regulation CDK17 MAP2K6 21871886 2491344 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK17 RARB 21868513 2473732 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Negative_regulation CDK18 CCND1 22851678 2677219 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , p27 ( Kip1 ) , and . Negative_regulation CDK18 CCND1 24399246 2906982 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) ( p21Cip1 , p27Kip1 , p15INK4B ) , and cyclin E were shown to be differentially expressed in latexin overexpressed cells and latexin silenced cells . Negative_regulation CDK18 CDKN1C 11347369 814340 The expression of , a [cyclin dependent kinase] *inhibitor* , is a strong indicator that the cells are exiting the cell cycle and are beginning to differentiate . Negative_regulation CDK18 CDKN1C 11529881 853645 We examine the cell proliferation activity and expression of [cyclin dependent kinase] *inhibitors* of the Cip/Kip family , p21Cip1 , p27Kip1 and , in foetal hamster lungs to determine the expression patterns of the cyclin dependent kinase inhibitors and to clarify the relationship between expression of the cyclin dependent kinase inhibitors and lung development . Negative_regulation CDK18 CDKN1C 15224347 1264961 The expression of ( Kip2 ) , a [cyclin dependent kinase] *inhibitor* that was also in the imprinted region , exhibited some variable increased expression predominantly in hepatic neoplasms from livers of female TG+ rats . Negative_regulation CDK18 CDKN1C 15537824 1367523 In contrast , EGCG accelerates terminal differentiation in normal human epidermal keratinocytes ( NHEK ) mediated partially by up-regulation of , a [cyclin dependent kinase] *inhibitor* that confers growth arrest and differentiation . Negative_regulation CDK18 CDKN1C 16731797 1566026 Differential expression of [cyclin dependent kinase] *inhibitors* , p27Kip1 and , by corticotropin in rat adrenal cortex . Negative_regulation CDK18 CDKN1C 16731797 1566064 An important role for the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p27Kip1 and , in the proliferation and differentiation of adrenal cells has been suggested by their knockout mice , which display adrenal hyperplasia . Negative_regulation CDK18 CDKN1C 18822693 1970550 The aim of this study was to establish the importance of , a unique [cyclin dependent kinase] *inhibitor* , in the oncogenesis of bladder carcinoma . Negative_regulation CDK18 CDKN1C 20503313 2263864 A small number of individuals with BWS ( 5-10 % ) have mutations in , a [cyclin dependent kinase] *inhibitor* of G1 cyclin complexes that functions as a negative regulator of cellular growth and proliferation . Negative_regulation CDK18 CDKN1C 21322636 2443323 p21 was found to be a key regulator of this process , because down-regulation of the [cyclin dependent kinase] *inhibitors* p27 ( CDKN1B/KIP1 ) or p57 ( ) or the tumor suppressor p53 ( TP53/LFS1 ) failed to induce proliferation and subsequent dedifferentiation . Negative_regulation CDK18 CDKN1C 22996691 2679063 Expression of , a BMP10 regulated [cyclin dependent kinase] *inhibitor* , was induced in Myocd-/- hearts , while BMP10 activated cardiogenic transcription factors , including NKX2.5 and MEF2c , were repressed . Negative_regulation CDK18 CDKN1C 7550351 323245 Genomic imprinting of , a [cyclin dependent kinase] *inhibitor* , in mouse . Negative_regulation CDK18 CDKN1C 7729683 302222 Cloning of , a [cyclin dependent kinase] *inhibitor* with unique domain structure and tissue distribution . Negative_regulation CDK18 CDKN1C 8923002 397231 The gene for insulin-like growth factor II (IGF2) is normally expressed from the paternal allele , while H19 and , a [cyclin dependent kinase] *inhibitor* , are expressed from the maternal allele . Negative_regulation CDK18 CDKN1C 9311734 455022 these include the gene for insulin-like growth factor II (IGF2) and H19 , which show abnormal imprint-specific expression and/or methylation in 20 % of BWS patients , and , a [cyclin dependent kinase] *inhibitor* , which we found showed biallelic expression in one of nine BWS patients studied . Negative_regulation CDK18 EPHB2 20855497 2325839 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Negative_regulation CDK18 EPHB2 21871886 2491348 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK18 IFI27 10198213 605058 73-kDa heat shock cognate protein interacts directly with , a [cyclin dependent kinase] *inhibitor* , during G1/S transition . Negative_regulation CDK18 IFI27 10198213 605096 In the present study , we demonstrated that 73hsc ( heat shock cognate protein ) , which belongs to the HSP70 family of molecular chaperones , interacts with , an *inhibitor* of [cyclin dependent kinase] , during G1/S transition . Negative_regulation CDK18 IFI27 10510349 651127 The treatment of macrophages with adenosine induces the expression of , a G1 [cyclin dependent kinase] *inhibitor* , in a protein kinase A-dependent way . Negative_regulation CDK18 IFI27 10859299 715258 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in many types of carcinomas . Negative_regulation CDK18 IFI27 10861499 705316 ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has an important role in the progression of cells from G ( 1 ) into S phase of the cell cycle . Negative_regulation CDK18 IFI27 10903892 713413 Minimal requirements for the nuclear localization of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK18 IFI27 11136238 786720 Previous work has shown that cyclin A can be cleaved at Arg-70/Arg-71 by a proteolytic activity present in an in vitro coupled transcription/translation system by using rabbit reticulocyte lysate programmed by plasmid DNA encoding ( KIP1 ) , a [cyclin dependent kinase] *inhibitor* , but not by plasmid DNAs encoding other cyclin dependent kinases inhibitors . Negative_regulation CDK18 IFI27 11164713 782681 [Cyclin dependent kinase] *inhibitors* , p21 ( waf1/cip1 ) and ( kip1 ) , are expressed site- and hair cycle-dependently in rat hair follicles . Negative_regulation CDK18 IFI27 11237531 790118 A major function of , also known as Kip1 , is to bind and *inhibit* [cyclin/cyclin dependent kinase] complexes , thereby blocking cell cycle progression . Negative_regulation CDK18 IFI27 11251953 793950 Low expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is a marker of poor prognosis in synovial sarcoma . Negative_regulation CDK18 IFI27 11251953 793969 Low expression of ( kip1 ) , a dominant [cyclin dependent kinase] *inhibitor* involved in G1-S transition of the cell cycle , recently has been reported to be associated with aggressive tumor growth . Negative_regulation CDK18 IFI27 11301477 803371 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in breast cancer . Negative_regulation CDK18 IFI27 11400230 824402 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , negatively regulates the G1 phase progression of the cell cycle by binding to the cyclin E/cyclin dependent kinase 2 complex . Negative_regulation CDK18 IFI27 11557117 861255 , a [cyclin dependent kinase] *inhibitor* , regulates the progression from G1 into the S phase by binding and inhibiting cyclin/cdks . Negative_regulation CDK18 IFI27 11744034 897900 Levels of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p16 and , were initially high in quiescent isolated cells and tissue ; Negative_regulation CDK18 IFI27 11745414 888970 Herein , expression of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p21 , and p57 and their associated kinase activities were examined in 61 cases of soft tissue smooth muscle tumors . Negative_regulation CDK18 IFI27 11850846 913204 LY294002 also causes an increase in , a [cyclin dependent kinase] *inhibitor* and results in the dephosphorylation of members of the pocket protein family . Negative_regulation CDK18 IFI27 11856766 914407 The differentiation was accompanied by a growth arrest and the upregulation of [cyclin dependent kinase] *inhibitors* , and p57 , as well as cyclin D(1) , whereas cyclin A was downregulated . Negative_regulation CDK18 IFI27 12097295 961280 Reduced expression level of , a [cyclin dependent kinase] *inhibitor* , is associated with high aggressiveness and poor prognosis of various malignant tumors , including gastric carcinoma . Negative_regulation CDK18 IFI27 12465754 1022275 Calcitriol induces a significant G0/G1 arrest and modulates p21 ( Waf/Cip1 ) and ( Kip1 ) , the [cyclin dependent kinase] *inhibitors* . Negative_regulation CDK18 IFI27 12663518 1074579 IP6 strongly increased the expression of CDKIs ( [cyclin dependent kinase] *inhibitors* ) , Cip1/p21 and , without any noticeable changes in G1 CDKs and cyclins , except a slight increase in cyclin D2 . Negative_regulation CDK18 IFI27 12771291 1094764 Parathyroid cell growth in patients with advanced secondary hyperparathyroidism : vitamin D receptor and [cyclin dependent kinase] *inhibitors* , p21 and . Negative_regulation CDK18 IFI27 12943995 1135813 We also observed a simultaneous increase in the expression of [cyclin-dependent-kinase] *inhibitors* , p21 , , p15 and p16 , associated with a loss in expression of Cyclin-A2 and Cyclin-E . Negative_regulation CDK18 IFI27 14618613 1188030 To examine the mechanism of the troglitazone induced growth inhibition , we determined ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , expression by Western blot analysis in troglitazone treated HLF cells . Negative_regulation CDK18 IFI27 15048878 1225266 We conclude that substrate dependent acquisition of proliferative phenotypes following repeated cycles of AAM injury correlates with modulation of the [cyclin dependent kinase] *inhibitors* , and p21 . Negative_regulation CDK18 IFI27 15138205 1246197 Gastric cells chronically exposed to H pylori in vitro develop resistance to apoptosis associated with low levels of , a [cyclin dependent kinase] *inhibitor* and haplo insufficient tumour suppressor gene that is downregulated in gastric cancer . Negative_regulation CDK18 IFI27 15224009 1264904 A high level of , an *inhibitor* of [cyclin dependent kinase] that correlates with the degree of in vitro apoptosis , is found in B-CLL cells . Negative_regulation CDK18 IFI27 15263796 1275081 The prognostic significance of cyclins D1 , E and [cyclin dependent kinase] *inhibitors* p21 ( Waf1/Cip1 ) , ( Kip1 ) in determining the risk of recurrence and progression with both univariate ( log rank test ) and multivariate ( Cox regression ) methods of analysis showed no statistically significance differences . Negative_regulation CDK18 IFI27 15378017 1324031 In the present study , we investigated the consequences of the combined loss of either of two [cyclin dependent kinase] *inhibitors* , p21 and , in cooperation with deletion of the INK4a/ARF locus . Negative_regulation CDK18 IFI27 15474987 1354688 Under the same conditions , adding MG or HK to VD3 or ATRA treatment further enlarged the G0/G1 cell population and increased the expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK18 IFI27 15491288 1321382 In addition , in myeloma cells subjected to growth-factor starvation , the upregulation of PGP9.5 was observed in association with that of ( Kip1 ) , a [cyclin-dependent-kinase] *inhibitor* , although the upregulation caused by irradiation was milder . Negative_regulation CDK18 IFI27 15799773 1390571 Several genes , including insulin-like growth factor 1 (IGF-1) and [cyclin dependent kinase] *inhibitor* ( ( Kip1 ) ) were induced by both injury types and these may have potential clinical application as markers of tissue damage . Negative_regulation CDK18 IFI27 15930262 1414433 Here , we found that VDUP1-/- fibroblast cells proliferated more rapidly compared with wild-type cells with reduced expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK18 IFI27 16020508 1465836 Tregs were blocked from cell cycle progression due to decrease of cyclin E and cyclin A and increase of ( p27kip [cyclin dependent kinase] *inhibitor* ) . Negative_regulation CDK18 IFI27 16039115 1473624 Levels of expression of cyclins , cyclin dependent kinases and [cyclin dependent kinase] *inhibitors* , p21 and , were analysed by western blotting . Negative_regulation CDK18 IFI27 16328436 1503630 [Cyclin dependent kinase] *inhibitors* CIP1 ( p21 ) and KIP1 ( ) in ovarian cancer . Negative_regulation CDK18 IFI27 16427178 1567190 In this study , under treatment with various concentrations of PA in MDA-MB 231 cell line , we checked mRNA levels for cyclin A and cyclin B1 and the protein levels of cyclin A and cyclin B1 , Cdc2 ( cyclin dependent kinases ) , p21 ( waf1/cip1 ) and ( Kip1 ) ( [cyclin dependent kinase] *inhibitors* ) , Cdc25C , Chk2 and Wee1 kinase ( cyclin dependent kinase relative factors ) in cell cycle G2/M phase . Negative_regulation CDK18 IFI27 16436005 1495314 ( kip1 ) , a universal [cyclin dependent kinase] *inhibitor* , is a useful marker for predicting clinical aggressiveness with various human tumors . Negative_regulation CDK18 IFI27 16564150 1555727 In contrast , protein levels of , a [cyclin dependent kinase] *inhibitor* , are increased after induction of ER-stress using tunicamycin . Negative_regulation CDK18 IFI27 17360552 1712773 As proof of principle , we studied the consequence of sporadic loss of , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK18 IFI27 17918155 1843892 Furthermore , we find that the growth inhibitory dose of R1881 leads to increases in the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21 and as well as to G1 arrest . Negative_regulation CDK18 IFI27 17979972 1874291 Terrein was found to downregulate cyclin B1 and Cdc2 without Cdc2 phosphorylation , but upregulated ( KIP1 ) ( p27 ) , a known *inhibitor* of [cyclin dependent kinase] . Negative_regulation CDK18 IFI27 18583941 1953351 Roles of [cyclin dependent kinase] *inhibitors* , p21/Cip1 ( p21 ) and p27/Kip1 ( ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation CDK18 IFI27 19026637 2022735 Activation of ERK1/2 was not affected by MacCM , and neither was the expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK18 IFI27 19147535 2026298 Two [cyclin dependent kinase] *inhibitors* , p18 ( Ink4c ) and ( Kip1 ) , are required for proper cerebellar development . Negative_regulation CDK18 IFI27 19276255 2046200 In retrospective studies , loss of ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has been associated with poor prognosis following colorectal cancer treatment . Negative_regulation CDK18 IFI27 19321452 2073945 Although HSC70 directly bound to ( Kip1 ) ( a [cyclin dependent kinase] *inhibitor* ) , histatin 3 increased the binding between those proteins but not with a peptide capable of binding to HSC70 . Negative_regulation CDK18 IFI27 19538337 2103588 In this study , we examined the role of melatonin on synoviocyte proliferation in primary cultured human fibroblast-like synoviocytes ( FLSs ) by analyzing protein expression of P21 ( CIP1 ) ( P21 ) and ( KIP1 ) ( P27 ) , the [cyclin dependent kinase] *inhibitors* that are important in cell cycle control , and the phosphorylation of mitogen activated protein kinases ( MAPKs ) . Negative_regulation CDK18 IFI27 19598246 2149823 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is also known to demarcate the prosensory region in the cochlear primordium , which consists of the sensory progenitors that have completed their terminal mitoses . Negative_regulation CDK18 IFI27 19720293 2133716 Trastuzumab , a humanized antibody directed against the Her2 receptor , induces the expression of ( kip1 ) , an intranuclear [cyclin dependent kinase] *inhibitor* in some breast cancer cells . Negative_regulation CDK18 IFI27 21443540 2438454 Furthermore , NS expression was associated with cellular proliferation in OSCC cell lines using siRNA , which upregulated , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK18 IFI27 21980125 2502941 Further , deletion of AMPKa2 but not AMPKa1 reduced the level of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , and increased the level of S-phase kinase associated protein 2 ( Skp2 ) , a known E3 ubiquitin ligase for p27 ( Kip1 ) , through activation of p52 nuclear factor kappa B ( NF-?B ) -2 . Negative_regulation CDK18 IFI27 22154697 2563130 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) of the CIP/KIP family , p21 , and p57 , mediate cell cycle inhibition . Negative_regulation CDK18 IFI27 22460505 2637146 Cell cycle analysis indicated thioridazine induced the down-regulation of cyclin D1 , cyclin A and CDK4 , and the induction of p21 and , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK18 IFI27 22851678 2677221 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , ( Kip1 ) , and cyclin D1 . Negative_regulation CDK18 IFI27 23255047 2827366 Skp2 mediated degradation of , a [cyclin dependent kinase] *inhibitor* , is involved in cell cycle regulation . Negative_regulation CDK18 IFI27 23721824 2819726 miR-370 induced proliferation was correlated with the downregulation of [cyclin dependent kinase] *inhibitors* , ( Kip1 ) and p21 ( Cip1 ) , and the upregulation of the cell cycle regulator cyclin D1 . Negative_regulation CDK18 IFI27 23888319 2902017 Our results found that curcumin inhibited cell proliferation , which was associated with upregulation of the [cyclin dependent kinase] *inhibitors* , and p21 , and downregulation of cyclin D1 . Negative_regulation CDK18 IFI27 23944957 2887990 We determined whether proliferation and IL-6 release are abnormal in ASM cells ( ASMCs ) from patients with severe asthma , and whether these features could be mediated by microRNA-221 and microRNA-222 , through modulation of the [cyclin dependent kinase] *inhibitors* , p21 ( WAF1 ) and ( kip1 ) . Negative_regulation CDK18 IFI27 24067984 2867179 Western blot analysis of key cell cycle regulators revealed that K-Rta mediated cell cycle arrest was associated with a decrease in cyclin A and phosphorylated Rb ( pS807/pS811 ) protein levels , both markers of S phase progression , and an increase in protein levels for , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK18 IFI27 24708177 2938881 Recently , STMN1 was reported to interact with , an *inhibitor* of [cyclin dependent kinase] complexes . Negative_regulation CDK18 IFI27 8654372 366894 Expression of Zta results in induction of the tumor suppressor protein , p53 , and the [cyclin dependent kinase] *inhibitors* , p21 and , as well as accumulation of hypophosphorylated pRb . Negative_regulation CDK18 IFI27 8845296 337856 We have examined the level of cyclin E , a G1 cyclin , and , a [cyclin dependent kinase] *inhibitor* , in BALB/c 3T3 cells . Negative_regulation CDK18 IFI27 9616167 509592 The identification of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* that contributes to cell cycle arrest and represents a link between extracellular signals and cell cycle , prompted us to study p27 protein in the lymphocytes from 88 patients with B-CLL and 32 patients with other chronic B-lymphoproliferative disorders . Negative_regulation CDK18 IFI27 9746784 533006 The ( kip-1 ) , a [cyclin dependent kinase] *inhibitor* which is important in blocking the cell cycle , was induced more quickly and potently by Ro 25-9716 ( 10 ( -7 ) mol/L , 0 to 5 days ) than by 1,25D3 , suggesting a possible mechanism by which these analogs inhibit proliferation of leukemic growth . Negative_regulation CDK18 IFI27 9891946 558598 Hence , we have determined the cell cycle profile , expressions and activities of the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21CIP1 and , during rat ventricular myocyte development . Negative_regulation CDK18 ITGA9 22138449 2536224 Furthermore , effects of p21 , a [cyclin dependent kinase] *inhibitor* , and integrin a9 ( ) were examined . Negative_regulation CDK18 MAP2K6 10597223 573494 p21Cip1/Waf1 [cyclin dependent kinase] inhibitor ( p21 ) is *inducible* by Raf and ( MAPKK ) , but the level of regulation is unknown . Negative_regulation CDK18 MAP2K6 21871886 2491354 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK18 RARB 21868513 2473733 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Negative_regulation CDK19 CCND1 22851678 2677204 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , p27 ( Kip1 ) , and . Negative_regulation CDK19 CCND1 24399246 2906977 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) ( p21Cip1 , p27Kip1 , p15INK4B ) , and cyclin E were shown to be differentially expressed in latexin overexpressed cells and latexin silenced cells . Negative_regulation CDK19 CD14 16574244 1582548 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation CDK19 CDKN1C 11347369 814335 The expression of , a [cyclin dependent kinase] *inhibitor* , is a strong indicator that the cells are exiting the cell cycle and are beginning to differentiate . Negative_regulation CDK19 CDKN1C 11529881 853630 We examine the cell proliferation activity and expression of [cyclin dependent kinase] *inhibitors* of the Cip/Kip family , p21Cip1 , p27Kip1 and , in foetal hamster lungs to determine the expression patterns of the cyclin dependent kinase inhibitors and to clarify the relationship between expression of the cyclin dependent kinase inhibitors and lung development . Negative_regulation CDK19 CDKN1C 15224347 1264956 The expression of ( Kip2 ) , a [cyclin dependent kinase] *inhibitor* that was also in the imprinted region , exhibited some variable increased expression predominantly in hepatic neoplasms from livers of female TG+ rats . Negative_regulation CDK19 CDKN1C 15537824 1367518 In contrast , EGCG accelerates terminal differentiation in normal human epidermal keratinocytes ( NHEK ) mediated partially by up-regulation of , a [cyclin dependent kinase] *inhibitor* that confers growth arrest and differentiation . Negative_regulation CDK19 CDKN1C 16731797 1566016 Differential expression of [cyclin dependent kinase] *inhibitors* , p27Kip1 and , by corticotropin in rat adrenal cortex . Negative_regulation CDK19 CDKN1C 16731797 1566054 An important role for the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p27Kip1 and , in the proliferation and differentiation of adrenal cells has been suggested by their knockout mice , which display adrenal hyperplasia . Negative_regulation CDK19 CDKN1C 18822693 1970545 The aim of this study was to establish the importance of , a unique [cyclin dependent kinase] *inhibitor* , in the oncogenesis of bladder carcinoma . Negative_regulation CDK19 CDKN1C 20503313 2263858 A small number of individuals with BWS ( 5-10 % ) have mutations in , a [cyclin dependent kinase] *inhibitor* of G1 cyclin complexes that functions as a negative regulator of cellular growth and proliferation . Negative_regulation CDK19 CDKN1C 21322636 2443313 p21 was found to be a key regulator of this process , because down-regulation of the [cyclin dependent kinase] *inhibitors* p27 ( CDKN1B/KIP1 ) or p57 ( ) or the tumor suppressor p53 ( TP53/LFS1 ) failed to induce proliferation and subsequent dedifferentiation . Negative_regulation CDK19 CDKN1C 22996691 2679058 Expression of , a BMP10 regulated [cyclin dependent kinase] *inhibitor* , was induced in Myocd-/- hearts , while BMP10 activated cardiogenic transcription factors , including NKX2.5 and MEF2c , were repressed . Negative_regulation CDK19 CDKN1C 7550351 323240 Genomic imprinting of , a [cyclin dependent kinase] *inhibitor* , in mouse . Negative_regulation CDK19 CDKN1C 7729683 302217 Cloning of , a [cyclin dependent kinase] *inhibitor* with unique domain structure and tissue distribution . Negative_regulation CDK19 CDKN1C 8923002 397221 The gene for insulin-like growth factor II (IGF2) is normally expressed from the paternal allele , while H19 and , a [cyclin dependent kinase] *inhibitor* , are expressed from the maternal allele . Negative_regulation CDK19 CDKN1C 9311734 455017 these include the gene for insulin-like growth factor II (IGF2) and H19 , which show abnormal imprint-specific expression and/or methylation in 20 % of BWS patients , and , a [cyclin dependent kinase] *inhibitor* , which we found showed biallelic expression in one of nine BWS patients studied . Negative_regulation CDK19 EPHB2 20855497 2325824 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Negative_regulation CDK19 EPHB2 21871886 2491298 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK19 IFI27 10198213 605048 73-kDa heat shock cognate protein interacts directly with , a [cyclin dependent kinase] *inhibitor* , during G1/S transition . Negative_regulation CDK19 IFI27 10198213 605086 In the present study , we demonstrated that 73hsc ( heat shock cognate protein ) , which belongs to the HSP70 family of molecular chaperones , interacts with , an *inhibitor* of [cyclin dependent kinase] , during G1/S transition . Negative_regulation CDK19 IFI27 10510349 651117 The treatment of macrophages with adenosine induces the expression of , a G1 [cyclin dependent kinase] *inhibitor* , in a protein kinase A-dependent way . Negative_regulation CDK19 IFI27 10859299 715253 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in many types of carcinomas . Negative_regulation CDK19 IFI27 10861499 705311 ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has an important role in the progression of cells from G ( 1 ) into S phase of the cell cycle . Negative_regulation CDK19 IFI27 10903892 713408 Minimal requirements for the nuclear localization of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK19 IFI27 11136238 786715 Previous work has shown that cyclin A can be cleaved at Arg-70/Arg-71 by a proteolytic activity present in an in vitro coupled transcription/translation system by using rabbit reticulocyte lysate programmed by plasmid DNA encoding ( KIP1 ) , a [cyclin dependent kinase] *inhibitor* , but not by plasmid DNAs encoding other cyclin dependent kinases inhibitors . Negative_regulation CDK19 IFI27 11164713 782671 [Cyclin dependent kinase] *inhibitors* , p21 ( waf1/cip1 ) and ( kip1 ) , are expressed site- and hair cycle-dependently in rat hair follicles . Negative_regulation CDK19 IFI27 11237531 790112 A major function of , also known as Kip1 , is to bind and *inhibit* [cyclin/cyclin dependent kinase] complexes , thereby blocking cell cycle progression . Negative_regulation CDK19 IFI27 11251953 793945 Low expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is a marker of poor prognosis in synovial sarcoma . Negative_regulation CDK19 IFI27 11251953 793964 Low expression of ( kip1 ) , a dominant [cyclin dependent kinase] *inhibitor* involved in G1-S transition of the cell cycle , recently has been reported to be associated with aggressive tumor growth . Negative_regulation CDK19 IFI27 11301477 803366 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in breast cancer . Negative_regulation CDK19 IFI27 11400230 824397 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , negatively regulates the G1 phase progression of the cell cycle by binding to the cyclin E/cyclin dependent kinase 2 complex . Negative_regulation CDK19 IFI27 11557117 861250 , a [cyclin dependent kinase] *inhibitor* , regulates the progression from G1 into the S phase by binding and inhibiting cyclin/cdks . Negative_regulation CDK19 IFI27 11744034 897895 Levels of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p16 and , were initially high in quiescent isolated cells and tissue ; Negative_regulation CDK19 IFI27 11745414 888965 Herein , expression of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p21 , and p57 and their associated kinase activities were examined in 61 cases of soft tissue smooth muscle tumors . Negative_regulation CDK19 IFI27 11850846 913194 LY294002 also causes an increase in , a [cyclin dependent kinase] *inhibitor* and results in the dephosphorylation of members of the pocket protein family . Negative_regulation CDK19 IFI27 11856766 914402 The differentiation was accompanied by a growth arrest and the upregulation of [cyclin dependent kinase] *inhibitors* , and p57 , as well as cyclin D(1) , whereas cyclin A was downregulated . Negative_regulation CDK19 IFI27 12097295 961275 Reduced expression level of , a [cyclin dependent kinase] *inhibitor* , is associated with high aggressiveness and poor prognosis of various malignant tumors , including gastric carcinoma . Negative_regulation CDK19 IFI27 12465754 1022265 Calcitriol induces a significant G0/G1 arrest and modulates p21 ( Waf/Cip1 ) and ( Kip1 ) , the [cyclin dependent kinase] *inhibitors* . Negative_regulation CDK19 IFI27 12663518 1074559 IP6 strongly increased the expression of CDKIs ( [cyclin dependent kinase] *inhibitors* ) , Cip1/p21 and , without any noticeable changes in G1 CDKs and cyclins , except a slight increase in cyclin D2 . Negative_regulation CDK19 IFI27 12771291 1094754 Parathyroid cell growth in patients with advanced secondary hyperparathyroidism : vitamin D receptor and [cyclin dependent kinase] *inhibitors* , p21 and . Negative_regulation CDK19 IFI27 12943995 1135803 We also observed a simultaneous increase in the expression of [cyclin-dependent-kinase] *inhibitors* , p21 , , p15 and p16 , associated with a loss in expression of Cyclin-A2 and Cyclin-E . Negative_regulation CDK19 IFI27 14618613 1188025 To examine the mechanism of the troglitazone induced growth inhibition , we determined ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , expression by Western blot analysis in troglitazone treated HLF cells . Negative_regulation CDK19 IFI27 15048878 1225256 We conclude that substrate dependent acquisition of proliferative phenotypes following repeated cycles of AAM injury correlates with modulation of the [cyclin dependent kinase] *inhibitors* , and p21 . Negative_regulation CDK19 IFI27 15138205 1246192 Gastric cells chronically exposed to H pylori in vitro develop resistance to apoptosis associated with low levels of , a [cyclin dependent kinase] *inhibitor* and haplo insufficient tumour suppressor gene that is downregulated in gastric cancer . Negative_regulation CDK19 IFI27 15224009 1264894 A high level of , an *inhibitor* of [cyclin dependent kinase] that correlates with the degree of in vitro apoptosis , is found in B-CLL cells . Negative_regulation CDK19 IFI27 15263796 1275076 The prognostic significance of cyclins D1 , E and [cyclin dependent kinase] *inhibitors* p21 ( Waf1/Cip1 ) , ( Kip1 ) in determining the risk of recurrence and progression with both univariate ( log rank test ) and multivariate ( Cox regression ) methods of analysis showed no statistically significance differences . Negative_regulation CDK19 IFI27 15378017 1324021 In the present study , we investigated the consequences of the combined loss of either of two [cyclin dependent kinase] *inhibitors* , p21 and , in cooperation with deletion of the INK4a/ARF locus . Negative_regulation CDK19 IFI27 15474987 1354683 Under the same conditions , adding MG or HK to VD3 or ATRA treatment further enlarged the G0/G1 cell population and increased the expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK19 IFI27 15491288 1321377 In addition , in myeloma cells subjected to growth-factor starvation , the upregulation of PGP9.5 was observed in association with that of ( Kip1 ) , a [cyclin-dependent-kinase] *inhibitor* , although the upregulation caused by irradiation was milder . Negative_regulation CDK19 IFI27 15799773 1390565 Several genes , including insulin-like growth factor 1 (IGF-1) and [cyclin dependent kinase] *inhibitor* ( ( Kip1 ) ) were induced by both injury types and these may have potential clinical application as markers of tissue damage . Negative_regulation CDK19 IFI27 15930262 1414428 Here , we found that VDUP1-/- fibroblast cells proliferated more rapidly compared with wild-type cells with reduced expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK19 IFI27 16020508 1465824 Tregs were blocked from cell cycle progression due to decrease of cyclin E and cyclin A and increase of ( p27kip [cyclin dependent kinase] *inhibitor* ) . Negative_regulation CDK19 IFI27 16039115 1473614 Levels of expression of cyclins , cyclin dependent kinases and [cyclin dependent kinase] *inhibitors* , p21 and , were analysed by western blotting . Negative_regulation CDK19 IFI27 16328436 1503625 [Cyclin dependent kinase] *inhibitors* CIP1 ( p21 ) and KIP1 ( ) in ovarian cancer . Negative_regulation CDK19 IFI27 16427178 1567180 In this study , under treatment with various concentrations of PA in MDA-MB 231 cell line , we checked mRNA levels for cyclin A and cyclin B1 and the protein levels of cyclin A and cyclin B1 , Cdc2 ( cyclin dependent kinases ) , p21 ( waf1/cip1 ) and ( Kip1 ) ( [cyclin dependent kinase] *inhibitors* ) , Cdc25C , Chk2 and Wee1 kinase ( cyclin dependent kinase relative factors ) in cell cycle G2/M phase . Negative_regulation CDK19 IFI27 16436005 1495309 ( kip1 ) , a universal [cyclin dependent kinase] *inhibitor* , is a useful marker for predicting clinical aggressiveness with various human tumors . Negative_regulation CDK19 IFI27 16564150 1555722 In contrast , protein levels of , a [cyclin dependent kinase] *inhibitor* , are increased after induction of ER-stress using tunicamycin . Negative_regulation CDK19 IFI27 17360552 1712763 As proof of principle , we studied the consequence of sporadic loss of , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK19 IFI27 17918155 1843882 Furthermore , we find that the growth inhibitory dose of R1881 leads to increases in the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21 and as well as to G1 arrest . Negative_regulation CDK19 IFI27 17979972 1874286 Terrein was found to downregulate cyclin B1 and Cdc2 without Cdc2 phosphorylation , but upregulated ( KIP1 ) ( p27 ) , a known *inhibitor* of [cyclin dependent kinase] . Negative_regulation CDK19 IFI27 18583941 1953327 Roles of [cyclin dependent kinase] *inhibitors* , p21/Cip1 ( p21 ) and p27/Kip1 ( ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation CDK19 IFI27 19026637 2022730 Activation of ERK1/2 was not affected by MacCM , and neither was the expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK19 IFI27 19147535 2026288 Two [cyclin dependent kinase] *inhibitors* , p18 ( Ink4c ) and ( Kip1 ) , are required for proper cerebellar development . Negative_regulation CDK19 IFI27 19276255 2046195 In retrospective studies , loss of ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has been associated with poor prognosis following colorectal cancer treatment . Negative_regulation CDK19 IFI27 19321452 2073940 Although HSC70 directly bound to ( Kip1 ) ( a [cyclin dependent kinase] *inhibitor* ) , histatin 3 increased the binding between those proteins but not with a peptide capable of binding to HSC70 . Negative_regulation CDK19 IFI27 19538337 2103578 In this study , we examined the role of melatonin on synoviocyte proliferation in primary cultured human fibroblast-like synoviocytes ( FLSs ) by analyzing protein expression of P21 ( CIP1 ) ( P21 ) and ( KIP1 ) ( P27 ) , the [cyclin dependent kinase] *inhibitors* that are important in cell cycle control , and the phosphorylation of mitogen activated protein kinases ( MAPKs ) . Negative_regulation CDK19 IFI27 19598246 2149818 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is also known to demarcate the prosensory region in the cochlear primordium , which consists of the sensory progenitors that have completed their terminal mitoses . Negative_regulation CDK19 IFI27 19720293 2133711 Trastuzumab , a humanized antibody directed against the Her2 receptor , induces the expression of ( kip1 ) , an intranuclear [cyclin dependent kinase] *inhibitor* in some breast cancer cells . Negative_regulation CDK19 IFI27 21443540 2438449 Furthermore , NS expression was associated with cellular proliferation in OSCC cell lines using siRNA , which upregulated , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK19 IFI27 21980125 2502936 Further , deletion of AMPKa2 but not AMPKa1 reduced the level of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , and increased the level of S-phase kinase associated protein 2 ( Skp2 ) , a known E3 ubiquitin ligase for p27 ( Kip1 ) , through activation of p52 nuclear factor kappa B ( NF-?B ) -2 . Negative_regulation CDK19 IFI27 22154697 2563125 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) of the CIP/KIP family , p21 , and p57 , mediate cell cycle inhibition . Negative_regulation CDK19 IFI27 22460505 2637136 Cell cycle analysis indicated thioridazine induced the down-regulation of cyclin D1 , cyclin A and CDK4 , and the induction of p21 and , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK19 IFI27 22851678 2677206 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , ( Kip1 ) , and cyclin D1 . Negative_regulation CDK19 IFI27 23255047 2827361 Skp2 mediated degradation of , a [cyclin dependent kinase] *inhibitor* , is involved in cell cycle regulation . Negative_regulation CDK19 IFI27 23721824 2819716 miR-370 induced proliferation was correlated with the downregulation of [cyclin dependent kinase] *inhibitors* , ( Kip1 ) and p21 ( Cip1 ) , and the upregulation of the cell cycle regulator cyclin D1 . Negative_regulation CDK19 IFI27 23888319 2902007 Our results found that curcumin inhibited cell proliferation , which was associated with upregulation of the [cyclin dependent kinase] *inhibitors* , and p21 , and downregulation of cyclin D1 . Negative_regulation CDK19 IFI27 23944957 2887980 We determined whether proliferation and IL-6 release are abnormal in ASM cells ( ASMCs ) from patients with severe asthma , and whether these features could be mediated by microRNA-221 and microRNA-222 , through modulation of the [cyclin dependent kinase] *inhibitors* , p21 ( WAF1 ) and ( kip1 ) . Negative_regulation CDK19 IFI27 24067984 2867174 Western blot analysis of key cell cycle regulators revealed that K-Rta mediated cell cycle arrest was associated with a decrease in cyclin A and phosphorylated Rb ( pS807/pS811 ) protein levels , both markers of S phase progression , and an increase in protein levels for , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK19 IFI27 24708177 2938876 Recently , STMN1 was reported to interact with , an *inhibitor* of [cyclin dependent kinase] complexes . Negative_regulation CDK19 IFI27 8654372 366882 Expression of Zta results in induction of the tumor suppressor protein , p53 , and the [cyclin dependent kinase] *inhibitors* , p21 and , as well as accumulation of hypophosphorylated pRb . Negative_regulation CDK19 IFI27 8845296 337841 We have examined the level of cyclin E , a G1 cyclin , and , a [cyclin dependent kinase] *inhibitor* , in BALB/c 3T3 cells . Negative_regulation CDK19 IFI27 9616167 509587 The identification of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* that contributes to cell cycle arrest and represents a link between extracellular signals and cell cycle , prompted us to study p27 protein in the lymphocytes from 88 patients with B-CLL and 32 patients with other chronic B-lymphoproliferative disorders . Negative_regulation CDK19 IFI27 9746784 533001 The ( kip-1 ) , a [cyclin dependent kinase] *inhibitor* which is important in blocking the cell cycle , was induced more quickly and potently by Ro 25-9716 ( 10 ( -7 ) mol/L , 0 to 5 days ) than by 1,25D3 , suggesting a possible mechanism by which these analogs inhibit proliferation of leukemic growth . Negative_regulation CDK19 IFI27 9891946 558578 Hence , we have determined the cell cycle profile , expressions and activities of the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21CIP1 and , during rat ventricular myocyte development . Negative_regulation CDK19 ITGA9 22138449 2536219 Furthermore , effects of p21 , a [cyclin dependent kinase] *inhibitor* , and integrin a9 ( ) were examined . Negative_regulation CDK19 LBP 16574244 1582549 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation CDK19 MAP2K6 10597223 573454 p21Cip1/Waf1 [cyclin dependent kinase] inhibitor ( p21 ) is *inducible* by Raf and ( MAPKK ) , but the level of regulation is unknown . Negative_regulation CDK19 MAP2K6 21871886 2491304 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK19 MSX1 17130681 1653068 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation CDK19 RARB 21868513 2473728 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Negative_regulation CDK19 TNF 14550746 1152698 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation CDK2 CCND1 10585273 571103 Complex mechanisms underlying impaired *activation* of Cdk4 and [Cdk2] in replicative senescence : roles of p16 , p21 , and . Negative_regulation CDK2 CCND1 11114718 759172 The kinase activities of cyclin D/CDK4 , 6 and cyclin E/CDK2 complexes were only slightly elevated , consistent with the findings that coordinate increases in p21 , and cyclin E *resulted* in an increase in [cyclin/CDK/p21] complexes . Negative_regulation CDK2 CCND1 14747065 1204261 Samples of NSG , pleomorphic adenoma ( PA ) , adenoid cystic carcinoma (ACC) , mucoepidermoid carcinoma (MEC) , epithelial-myoepithelial carcinoma (EMC) , malignant myoepithelioma ( MEM ) , carcinoma ex pleomorphic adenoma (CEPA) , and polymorphous , low-grade adenocarcinoma ( PLGA ) were examined immunohistochemically using antibodies to , cyclin dependent kinase 4 (CDK-4) , retinoblastoma protein ( pRb ) , [CDK] *inhibitor* p16 and transcription factor E2F-1 . Negative_regulation CDK2 CCND1 19046439 2001643 In sensitive breast cancer lines , the reduction in *led* to release of sequestered CDK inhibitors , p27Kip1 and p21Cip1 , and association of these inhibitors with [cyclin E/CDK2 complexes] . Negative_regulation CDK2 CCND1 20816752 2324983 Analysis of G1 cell cycle regulators expression revealed 2M4VP increased expression of CDK inhibitor , p21Waf1/Cip1 and p15 INK4b , decreased expression of and cyclin E , and *inhibited* kinase activities of CDK4 and [CDK2] . Negative_regulation CDK2 CCND1 21429724 2523557 HEGU and isoangustone A reduced the levels of CDK2 and CDK4 as well as cyclin A and proteins , and also *induced* a decrease in [CDK2] activity . Negative_regulation CDK2 CCND1 22851678 2677180 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , p27 ( Kip1 ) , and . Negative_regulation CDK2 CCND1 24399246 2906969 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) ( p21Cip1 , p27Kip1 , p15INK4B ) , and cyclin E were shown to be differentially expressed in latexin overexpressed cells and latexin silenced cells . Negative_regulation CDK2 CCND1 9169494 432865 overexpression *resulted* in a concomitant increase in CDK4 levels in the adult myocardium , as well as modest increases in proliferating cell nuclear antigen and [CDK2] levels . Negative_regulation CDK2 CCND1 9344597 459128 Thus , even though overexpression of can *induce* the expression of cyclin E and phosphorylated [CDK2] , premature activation of cyclin E-CDK2 kinase activity in quiescent cells or during progression through G1 appears to be blocked by CDKIs . Negative_regulation CDK2 CDKN1C 10551775 565257 Selective expression by the tetracycline analog doxycycline to levels comparable to those observed on DEX induction *resulted* in a 1.7-fold increase in the doubling time and a shift of HeLa cells to the G1 phase as well as a decrease in [CDK2] activity . Negative_regulation CDK2 CDKN1C 10731669 678281 Mice lacking a [CDK] *inhibitor* , , exhibit skeletal abnormalities and growth retardation . Negative_regulation CDK2 CDKN1C 11347369 814327 The expression of , a [cyclin dependent kinase] *inhibitor* , is a strong indicator that the cells are exiting the cell cycle and are beginning to differentiate . Negative_regulation CDK2 CDKN1C 11529881 853606 We examine the cell proliferation activity and expression of [cyclin dependent kinase] *inhibitors* of the Cip/Kip family , p21Cip1 , p27Kip1 and , in foetal hamster lungs to determine the expression patterns of the cyclin dependent kinase inhibitors and to clarify the relationship between expression of the cyclin dependent kinase inhibitors and lung development . Negative_regulation CDK2 CDKN1C 15224347 1264948 The expression of ( Kip2 ) , a [cyclin dependent kinase] *inhibitor* that was also in the imprinted region , exhibited some variable increased expression predominantly in hepatic neoplasms from livers of female TG+ rats . Negative_regulation CDK2 CDKN1C 15537824 1367510 In contrast , EGCG accelerates terminal differentiation in normal human epidermal keratinocytes ( NHEK ) mediated partially by up-regulation of , a [cyclin dependent kinase] *inhibitor* that confers growth arrest and differentiation . Negative_regulation CDK2 CDKN1C 16731797 1566000 Differential expression of [cyclin dependent kinase] *inhibitors* , p27Kip1 and , by corticotropin in rat adrenal cortex . Negative_regulation CDK2 CDKN1C 16731797 1566038 An important role for the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p27Kip1 and , in the proliferation and differentiation of adrenal cells has been suggested by their knockout mice , which display adrenal hyperplasia . Negative_regulation CDK2 CDKN1C 17464323 1766505 Here , we report that selective p57(Kip2) expression sensitizes cancer cells to apoptotic agents such as cisplatin , etoposide and staurosporine (STS) via a mechanism , which does not require *mediated* inhibition of [CDK] . Negative_regulation CDK2 CDKN1C 18822693 1970537 The aim of this study was to establish the importance of , a unique [cyclin dependent kinase] *inhibitor* , in the oncogenesis of bladder carcinoma . Negative_regulation CDK2 CDKN1C 18981479 1983590 Similarly , FGF4 deprivation resulted in CDK1 inhibition by overexpressing two [CDK-specific] *inhibitors* , and p21/CIP1 . Negative_regulation CDK2 CDKN1C 20503313 2263850 A small number of individuals with BWS ( 5-10 % ) have mutations in , a [cyclin dependent kinase] *inhibitor* of G1 cyclin complexes that functions as a negative regulator of cellular growth and proliferation . Negative_regulation CDK2 CDKN1C 21322636 2443297 p21 was found to be a key regulator of this process , because down-regulation of the [cyclin dependent kinase] *inhibitors* p27 ( CDKN1B/KIP1 ) or p57 ( ) or the tumor suppressor p53 ( TP53/LFS1 ) failed to induce proliferation and subsequent dedifferentiation . Negative_regulation CDK2 CDKN1C 21769918 2494976 , a [CDK] *inhibitor* , is frequently down-regulated in several malignancy tumors . Negative_regulation CDK2 CDKN1C 22569127 2625022 Phosphorylation of at T143 by p38 *enhances* its association with and inhibition of [Cdk2] , which results in cell-cycle delay upon stress . Negative_regulation CDK2 CDKN1C 22996691 2679050 Expression of , a BMP10 regulated [cyclin dependent kinase] *inhibitor* , was induced in Myocd-/- hearts , while BMP10 activated cardiogenic transcription factors , including NKX2.5 and MEF2c , were repressed . Negative_regulation CDK2 CDKN1C 7550351 323232 Genomic imprinting of , a [cyclin dependent kinase] *inhibitor* , in mouse . Negative_regulation CDK2 CDKN1C 7729683 302209 Cloning of , a [cyclin dependent kinase] *inhibitor* with unique domain structure and tissue distribution . Negative_regulation CDK2 CDKN1C 8923002 397205 The gene for insulin-like growth factor II (IGF2) is normally expressed from the paternal allele , while H19 and , a [cyclin dependent kinase] *inhibitor* , are expressed from the maternal allele . Negative_regulation CDK2 CDKN1C 9311734 455009 these include the gene for insulin-like growth factor II (IGF2) and H19 , which show abnormal imprint-specific expression and/or methylation in 20 % of BWS patients , and , a [cyclin dependent kinase] *inhibitor* , which we found showed biallelic expression in one of nine BWS patients studied . Negative_regulation CDK2 EPHB2 15917995 1413220 We have demonstrated that ( MAPK ) signaling was *involved* in the induction of both p15(INK4b)and p16(INK4a) [CDK] inhibitors and growth inhibition of hepatoma cell HepG2 triggered by the tumor promoter tetradecanoyl phorbol acetate ( TPA ) . Negative_regulation CDK2 EPHB2 20855497 2325798 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Negative_regulation CDK2 EPHB2 21871886 2491200 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK2 HES2 18275847 1878135 CCN3 transfection to Kusa-A1 inhibited osteogenic differentiation and cell proliferation , which is accompanied by upregulation of , Notch downstream targets , and p21 , a [CDK] *inhibitor* . Negative_regulation CDK2 ID1 12203366 983161 Ectopic expression in CNE1 cells *resulted* in an increase in serum independent cell growth , percentage of cells in S phase , and phosphorylation of RB and [cyclin dependent kinase 2] proteins . Negative_regulation CDK2 IFI27 10198213 605032 73-kDa heat shock cognate protein interacts directly with , a [cyclin dependent kinase] *inhibitor* , during G1/S transition . Negative_regulation CDK2 IFI27 10198213 605070 In the present study , we demonstrated that 73hsc ( heat shock cognate protein ) , which belongs to the HSP70 family of molecular chaperones , interacts with , an *inhibitor* of [cyclin dependent kinase] , during G1/S transition . Negative_regulation CDK2 IFI27 10383885 624663 Blocking hyperploid progression through hydroxyurea or ectopically expressed ( Kip1 ) , a G1-specific [Cdk] *inhibitor* , abrogates AMD cytotoxicity . Negative_regulation CDK2 IFI27 10510349 651101 The treatment of macrophages with adenosine induces the expression of , a G1 [cyclin dependent kinase] *inhibitor* , in a protein kinase A-dependent way . Negative_regulation CDK2 IFI27 10791951 707953 The ( Kip1 ) binds to the cyclin/CDK2 complexes and *causes* a decrease in [CDK2] kinase activity . Negative_regulation CDK2 IFI27 10811608 693070 The [Cdk2] *inhibitor* , ( Kip1 ) , is degraded in a phosphorylation- and ubiquitylation dependent manner at the G ( 1 ) -S transition of the cell cycle . Negative_regulation CDK2 IFI27 10859299 715245 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in many types of carcinomas . Negative_regulation CDK2 IFI27 10861499 705303 ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has an important role in the progression of cells from G ( 1 ) into S phase of the cell cycle . Negative_regulation CDK2 IFI27 10896783 711675 Evaluation of the kinase activity of cyclin-Cdk complexes showed that RA increases ( Kip1 ) expression in CH27 cells leading to markedly reduced cyclin A/Cdk2 kinase activity and slightly *reduced* [cyclin E/Cdk2] kinase activity , with no effect on cyclin D/Cdk4 and cyclin D/Cdk6 activities . Negative_regulation CDK2 IFI27 10903892 713400 Minimal requirements for the nuclear localization of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK2 IFI27 10970882 728862 These functional and biochemical data provide a direct link between c-Myc transcriptional regulation and ubiquitin mediated proteolysis and together support the view that c-Myc promotes G ( 1 ) exit in part via Cul1 dependent ubiquitination and degradation of the [CDK] *inhibitor* , ( kip1 ) . Negative_regulation CDK2 IFI27 11136238 786707 Previous work has shown that cyclin A can be cleaved at Arg-70/Arg-71 by a proteolytic activity present in an in vitro coupled transcription/translation system by using rabbit reticulocyte lysate programmed by plasmid DNA encoding ( KIP1 ) , a [cyclin dependent kinase] *inhibitor* , but not by plasmid DNAs encoding other cyclin dependent kinases inhibitors . Negative_regulation CDK2 IFI27 11164713 782655 [Cyclin dependent kinase] *inhibitors* , p21 ( waf1/cip1 ) and ( kip1 ) , are expressed site- and hair cycle-dependently in rat hair follicles . Negative_regulation CDK2 IFI27 11164713 782685 These results imply that [CDK] *inhibitors* , p21 ( waf1/cip1 ) and ( kip1 ) , are involved in the differentiation of follicular epithelial cells . Negative_regulation CDK2 IFI27 11237531 790104 A major function of , also known as Kip1 , is to bind and *inhibit* [cyclin/cyclin dependent kinase] complexes , thereby blocking cell cycle progression . Negative_regulation CDK2 IFI27 11251953 793937 Low expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is a marker of poor prognosis in synovial sarcoma . Negative_regulation CDK2 IFI27 11251953 793956 Low expression of ( kip1 ) , a dominant [cyclin dependent kinase] *inhibitor* involved in G1-S transition of the cell cycle , recently has been reported to be associated with aggressive tumor growth . Negative_regulation CDK2 IFI27 11301477 803358 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in breast cancer . Negative_regulation CDK2 IFI27 11400230 824389 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , negatively regulates the G1 phase progression of the cell cycle by binding to the cyclin E/cyclin dependent kinase 2 complex . Negative_regulation CDK2 IFI27 11438580 833015 Loss of ( Kip1 ) , another [Cdk] *inhibitor* , precedes cell death in neocortical neurons subjected to oxygen-glucose deprivation in vitro . Negative_regulation CDK2 IFI27 11494151 846196 However , in non-adherent cells no molecular mechanism has yet been proposed for the cell adhesion dependent up-regulation of the cyclin dependent kinase inhibitor (CKI) , and the associated *inhibition* of cyclin [E-CDK2] . Negative_regulation CDK2 IFI27 11557117 861242 , a [cyclin dependent kinase] *inhibitor* , regulates the progression from G1 into the S phase by binding and inhibiting cyclin/cdks . Negative_regulation CDK2 IFI27 11744034 897887 Levels of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p16 and , were initially high in quiescent isolated cells and tissue ; Negative_regulation CDK2 IFI27 11745414 888957 Herein , expression of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p21 , and p57 and their associated kinase activities were examined in 61 cases of soft tissue smooth muscle tumors . Negative_regulation CDK2 IFI27 11850846 913178 LY294002 also causes an increase in , a [cyclin dependent kinase] *inhibitor* and results in the dephosphorylation of members of the pocket protein family . Negative_regulation CDK2 IFI27 11856766 914394 The differentiation was accompanied by a growth arrest and the upregulation of [cyclin dependent kinase] *inhibitors* , and p57 , as well as cyclin D(1) , whereas cyclin A was downregulated . Negative_regulation CDK2 IFI27 12097295 961267 Reduced expression level of , a [cyclin dependent kinase] *inhibitor* , is associated with high aggressiveness and poor prognosis of various malignant tumors , including gastric carcinoma . Negative_regulation CDK2 IFI27 12465754 1022249 Calcitriol induces a significant G0/G1 arrest and modulates p21 ( Waf/Cip1 ) and ( Kip1 ) , the [cyclin dependent kinase] *inhibitors* . Negative_regulation CDK2 IFI27 12663518 1074527 IP6 strongly increased the expression of CDKIs ( [cyclin dependent kinase] *inhibitors* ) , Cip1/p21 and , without any noticeable changes in G1 CDKs and cyclins , except a slight increase in cyclin D2 . Negative_regulation CDK2 IFI27 12771291 1094738 Parathyroid cell growth in patients with advanced secondary hyperparathyroidism : vitamin D receptor and [cyclin dependent kinase] *inhibitors* , p21 and . Negative_regulation CDK2 IFI27 12871207 1142269 The induction of the premature senescence programme is mediated by inhibition of [Cdk2] kinase activity , and ( KIP1 ) is *required* to maintain the senescent phenotype . Negative_regulation CDK2 IFI27 12943995 1135787 We also observed a simultaneous increase in the expression of [cyclin-dependent-kinase] *inhibitors* , p21 , , p15 and p16 , associated with a loss in expression of Cyclin-A2 and Cyclin-E . Negative_regulation CDK2 IFI27 14593714 1160037 Oncogenic RAS mutants such as v-Ha-RAS trigger cell cycle entry ( G0-G1 transition ) mainly by up-regulating cyclin D1 , an activator of cyclin dependent kinases (CDK) , and down regulating , a [CDK] *inhibitor* . Negative_regulation CDK2 IFI27 14618613 1188017 To examine the mechanism of the troglitazone induced growth inhibition , we determined ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , expression by Western blot analysis in troglitazone treated HLF cells . Negative_regulation CDK2 IFI27 14734859 1199530 Cross linking of mIgM of WEHIdelta cells causes accumulation of the [Cdk] *inhibitor* , ( Kip1 ) . Negative_regulation CDK2 IFI27 15048878 1225240 We conclude that substrate dependent acquisition of proliferative phenotypes following repeated cycles of AAM injury correlates with modulation of the [cyclin dependent kinase] *inhibitors* , and p21 . Negative_regulation CDK2 IFI27 15057270 1244157 ( Kip1 ) ( p27 ) , a [CDK] *inhibitor* , migrates into the nucleus , where it controls cyclin-CDK complex activity for proper cell cycle progression . Negative_regulation CDK2 IFI27 15138205 1246184 Gastric cells chronically exposed to H pylori in vitro develop resistance to apoptosis associated with low levels of , a [cyclin dependent kinase] *inhibitor* and haplo insufficient tumour suppressor gene that is downregulated in gastric cancer . Negative_regulation CDK2 IFI27 15224009 1264878 A high level of , an *inhibitor* of [cyclin dependent kinase] that correlates with the degree of in vitro apoptosis , is found in B-CLL cells . Negative_regulation CDK2 IFI27 15263796 1275068 The prognostic significance of cyclins D1 , E and [cyclin dependent kinase] *inhibitors* p21 ( Waf1/Cip1 ) , ( Kip1 ) in determining the risk of recurrence and progression with both univariate ( log rank test ) and multivariate ( Cox regression ) methods of analysis showed no statistically significance differences . Negative_regulation CDK2 IFI27 15378017 1324005 In the present study , we investigated the consequences of the combined loss of either of two [cyclin dependent kinase] *inhibitors* , p21 and , in cooperation with deletion of the INK4a/ARF locus . Negative_regulation CDK2 IFI27 15474987 1354675 Under the same conditions , adding MG or HK to VD3 or ATRA treatment further enlarged the G0/G1 cell population and increased the expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK2 IFI27 15491288 1321369 In addition , in myeloma cells subjected to growth-factor starvation , the upregulation of PGP9.5 was observed in association with that of ( Kip1 ) , a [cyclin-dependent-kinase] *inhibitor* , although the upregulation caused by irradiation was milder . Negative_regulation CDK2 IFI27 15799773 1390557 Several genes , including insulin-like growth factor 1 (IGF-1) and [cyclin dependent kinase] *inhibitor* ( ( Kip1 ) ) were induced by both injury types and these may have potential clinical application as markers of tissue damage . Negative_regulation CDK2 IFI27 15930262 1414420 Here , we found that VDUP1-/- fibroblast cells proliferated more rapidly compared with wild-type cells with reduced expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK2 IFI27 16020508 1465808 Tregs were blocked from cell cycle progression due to decrease of cyclin E and cyclin A and increase of ( p27kip [cyclin dependent kinase] *inhibitor* ) . Negative_regulation CDK2 IFI27 16039115 1473598 Levels of expression of cyclins , cyclin dependent kinases and [cyclin dependent kinase] *inhibitors* , p21 and , were analysed by western blotting . Negative_regulation CDK2 IFI27 16230398 1470082 Using dominant negative Cdk2 and a degradation stable p27 mutant , we show that cell cycle progression induced by SF/HGF requires [Cdk2] function and *inhibition* . Negative_regulation CDK2 IFI27 16322758 1519042 P19ink4d knockdown together with depletion of , another [CDK] *inhibitor* regulated by 1,25D3 and RA , rendered cells resistant to ligand induced growth arrest . Negative_regulation CDK2 IFI27 16328436 1503617 [Cyclin dependent kinase] *inhibitors* CIP1 ( p21 ) and KIP1 ( ) in ovarian cancer . Negative_regulation CDK2 IFI27 16427178 1567164 In this study , under treatment with various concentrations of PA in MDA-MB 231 cell line , we checked mRNA levels for cyclin A and cyclin B1 and the protein levels of cyclin A and cyclin B1 , Cdc2 ( cyclin dependent kinases ) , p21 ( waf1/cip1 ) and ( Kip1 ) ( [cyclin dependent kinase] *inhibitors* ) , Cdc25C , Chk2 and Wee1 kinase ( cyclin dependent kinase relative factors ) in cell cycle G2/M phase . Negative_regulation CDK2 IFI27 16436005 1495301 ( kip1 ) , a universal [cyclin dependent kinase] *inhibitor* , is a useful marker for predicting clinical aggressiveness with various human tumors . Negative_regulation CDK2 IFI27 16564150 1555714 In contrast , protein levels of , a [cyclin dependent kinase] *inhibitor* , are increased after induction of ER-stress using tunicamycin . Negative_regulation CDK2 IFI27 17254967 1691042 phosphorylation by Src *regulates* inhibition of cyclin [E-Cdk2] . Negative_regulation CDK2 IFI27 17360552 1712747 As proof of principle , we studied the consequence of sporadic loss of , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK2 IFI27 17918155 1843866 Furthermore , we find that the growth inhibitory dose of R1881 leads to increases in the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21 and as well as to G1 arrest . Negative_regulation CDK2 IFI27 17979972 1874278 Terrein was found to downregulate cyclin B1 and Cdc2 without Cdc2 phosphorylation , but upregulated ( KIP1 ) ( p27 ) , a known *inhibitor* of [cyclin dependent kinase] . Negative_regulation CDK2 IFI27 18583941 1953293 Roles of [cyclin dependent kinase] *inhibitors* , p21/Cip1 ( p21 ) and p27/Kip1 ( ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation CDK2 IFI27 19026637 2022722 Activation of ERK1/2 was not affected by MacCM , and neither was the expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK2 IFI27 19147535 2026272 Two [cyclin dependent kinase] *inhibitors* , p18 ( Ink4c ) and ( Kip1 ) , are required for proper cerebellar development . Negative_regulation CDK2 IFI27 19276255 2046187 In retrospective studies , loss of ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has been associated with poor prognosis following colorectal cancer treatment . Negative_regulation CDK2 IFI27 19295442 2064011 Treatment with cudraflavone B downregulated the cyclins and CDKs and upregulated the expression of p21 and , a [CDK] *inhibitor* . Negative_regulation CDK2 IFI27 19321452 2073932 Although HSC70 directly bound to ( Kip1 ) ( a [cyclin dependent kinase] *inhibitor* ) , histatin 3 increased the binding between those proteins but not with a peptide capable of binding to HSC70 . Negative_regulation CDK2 IFI27 19538337 2103562 In this study , we examined the role of melatonin on synoviocyte proliferation in primary cultured human fibroblast-like synoviocytes ( FLSs ) by analyzing protein expression of P21 ( CIP1 ) ( P21 ) and ( KIP1 ) ( P27 ) , the [cyclin dependent kinase] *inhibitors* that are important in cell cycle control , and the phosphorylation of mitogen activated protein kinases ( MAPKs ) . Negative_regulation CDK2 IFI27 19598246 2149810 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is also known to demarcate the prosensory region in the cochlear primordium , which consists of the sensory progenitors that have completed their terminal mitoses . Negative_regulation CDK2 IFI27 19720293 2133703 Trastuzumab , a humanized antibody directed against the Her2 receptor , induces the expression of ( kip1 ) , an intranuclear [cyclin dependent kinase] *inhibitor* in some breast cancer cells . Negative_regulation CDK2 IFI27 20086097 2218910 An increased nuclear accumulation of , an *inhibitor* of the [cyclin E-cdk2 complex] , was also observed for the mutant epithelium . Negative_regulation CDK2 IFI27 21278490 2392866 GSK-3 inactivation or depletion promotes ß-cell replication via down regulation of the [CDK] *inhibitor* , ( Kip1 ) . Negative_regulation CDK2 IFI27 21278797 2425695 Notably , , the [CDK] *inhibitor* , is increased in Mitf depleted cells and is required for exacerbation of the tumorigenic properties of melanoma cells . Negative_regulation CDK2 IFI27 21443540 2438441 Furthermore , NS expression was associated with cellular proliferation in OSCC cell lines using siRNA , which upregulated , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK2 IFI27 21980125 2502928 Further , deletion of AMPKa2 but not AMPKa1 reduced the level of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , and increased the level of S-phase kinase associated protein 2 ( Skp2 ) , a known E3 ubiquitin ligase for p27 ( Kip1 ) , through activation of p52 nuclear factor kappa B ( NF-?B ) -2 . Negative_regulation CDK2 IFI27 22154697 2563117 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) of the CIP/KIP family , p21 , and p57 , mediate cell cycle inhibition . Negative_regulation CDK2 IFI27 22460505 2637120 Cell cycle analysis indicated thioridazine induced the down-regulation of cyclin D1 , cyclin A and CDK4 , and the induction of p21 and , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK2 IFI27 22851678 2677182 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , ( Kip1 ) , and cyclin D1 . Negative_regulation CDK2 IFI27 23255047 2827353 Skp2 mediated degradation of , a [cyclin dependent kinase] *inhibitor* , is involved in cell cycle regulation . Negative_regulation CDK2 IFI27 23721824 2819700 miR-370 induced proliferation was correlated with the downregulation of [cyclin dependent kinase] *inhibitors* , ( Kip1 ) and p21 ( Cip1 ) , and the upregulation of the cell cycle regulator cyclin D1 . Negative_regulation CDK2 IFI27 23888319 2901991 Our results found that curcumin inhibited cell proliferation , which was associated with upregulation of the [cyclin dependent kinase] *inhibitors* , and p21 , and downregulation of cyclin D1 . Negative_regulation CDK2 IFI27 23944957 2887964 We determined whether proliferation and IL-6 release are abnormal in ASM cells ( ASMCs ) from patients with severe asthma , and whether these features could be mediated by microRNA-221 and microRNA-222 , through modulation of the [cyclin dependent kinase] *inhibitors* , p21 ( WAF1 ) and ( kip1 ) . Negative_regulation CDK2 IFI27 24067984 2867166 Western blot analysis of key cell cycle regulators revealed that K-Rta mediated cell cycle arrest was associated with a decrease in cyclin A and phosphorylated Rb ( pS807/pS811 ) protein levels , both markers of S phase progression , and an increase in protein levels for , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK2 IFI27 24269842 2893089 In order to assess the role of Cdk2 under limiting conditions , we used Skp2 knockout mice that exhibit increased levels of [Cdk] *inhibitor* , ( Kip1 ) , which is able to inhibit Cdk2 and Cdk1 . Negative_regulation CDK2 IFI27 24500246 2914030 In this study , a fusion protein consisting of mVenus and a defective mutant of [CDK] *inhibitor* , ( p27K ( - ) ) was shown to be able to identify and isolate a population of quiescent cells and to effectively visualize the G0 to G1 transition . Negative_regulation CDK2 IFI27 24708177 2938868 Recently , STMN1 was reported to interact with , an *inhibitor* of [cyclin dependent kinase] complexes . Negative_regulation CDK2 IFI27 8033213 264080 , a novel *inhibitor* of G1 [cyclin-Cdk] protein kinase activity , is related to p21 . Negative_regulation CDK2 IFI27 8654372 366866 Expression of Zta results in induction of the tumor suppressor protein , p53 , and the [cyclin dependent kinase] *inhibitors* , p21 and , as well as accumulation of hypophosphorylated pRb . Negative_regulation CDK2 IFI27 8845296 337817 We have examined the level of cyclin E , a G1 cyclin , and , a [cyclin dependent kinase] *inhibitor* , in BALB/c 3T3 cells . Negative_regulation CDK2 IFI27 9531600 496920 In addition , MPA prevented the IL-2 induced elimination of ( Kip1 ) , a [CDK] *inhibitor* , and resulted in the retention of high levels of p27 ( Kip1 ) in IL-2/PHA-L treated T cells bound to CDK2 . Negative_regulation CDK2 IFI27 9616167 509579 The identification of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* that contributes to cell cycle arrest and represents a link between extracellular signals and cell cycle , prompted us to study p27 protein in the lymphocytes from 88 patients with B-CLL and 32 patients with other chronic B-lymphoproliferative disorders . Negative_regulation CDK2 IFI27 9746784 532993 The ( kip-1 ) , a [cyclin dependent kinase] *inhibitor* which is important in blocking the cell cycle , was induced more quickly and potently by Ro 25-9716 ( 10 ( -7 ) mol/L , 0 to 5 days ) than by 1,25D3 , suggesting a possible mechanism by which these analogs inhibit proliferation of leukemic growth . Negative_regulation CDK2 IFI27 9789031 542005 The cyclin dependent kinase inhibitor p15(INK4B) blocks association of cyclin dependent kinase (CDK)4/cyclin D and ( kip-1 ) *blocks* activity of [CDK2/cyclin A] and CDK2/cyclin E , complexes that are mandatory for cell-cycle progression . Negative_regulation CDK2 IFI27 9891946 558546 Hence , we have determined the cell cycle profile , expressions and activities of the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21CIP1 and , during rat ventricular myocyte development . Negative_regulation CDK2 ITGA9 22138449 2536211 Furthermore , effects of p21 , a [cyclin dependent kinase] *inhibitor* , and integrin a9 ( ) were examined . Negative_regulation CDK2 MAP2K6 10597223 573383 p21Cip1/Waf1 [cyclin dependent kinase] inhibitor ( p21 ) is *inducible* by Raf and ( MAPKK ) , but the level of regulation is unknown . Negative_regulation CDK2 MAP2K6 21871886 2491206 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK2 MAP2K6 22997239 2694247 P = .02 when mean tumor volume was compared for inhibitor vs MEK inhibitor plus [CDK2/4] *inhibition* ; Negative_regulation CDK2 MYH16 15466361 1305439 Cyclic strain increased the activity of [cyclin dependent kinase 2 (cdk2)] and the cellular level of cyclin A , and *inhibited* the expression of and formation of myotubes in C2C12 cultures . Negative_regulation CDK2 MYH3 15466361 1305446 Cyclic strain increased the activity of [cyclin dependent kinase 2 (cdk2)] and the cellular level of cyclin A , and *inhibited* the expression of and formation of myotubes in C2C12 cultures . Negative_regulation CDK2 RARB 21868513 2473720 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Negative_regulation CDK2 TNF 10339667 616036 *reduced* the expression of the [cyclin E-cdk2 complex] . Negative_regulation CDK20 CCND1 22851678 2677207 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , p27 ( Kip1 ) , and . Negative_regulation CDK20 CCND1 24399246 2906978 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) ( p21Cip1 , p27Kip1 , p15INK4B ) , and cyclin E were shown to be differentially expressed in latexin overexpressed cells and latexin silenced cells . Negative_regulation CDK20 CDKN1C 11347369 814336 The expression of , a [cyclin dependent kinase] *inhibitor* , is a strong indicator that the cells are exiting the cell cycle and are beginning to differentiate . Negative_regulation CDK20 CDKN1C 11529881 853633 We examine the cell proliferation activity and expression of [cyclin dependent kinase] *inhibitors* of the Cip/Kip family , p21Cip1 , p27Kip1 and , in foetal hamster lungs to determine the expression patterns of the cyclin dependent kinase inhibitors and to clarify the relationship between expression of the cyclin dependent kinase inhibitors and lung development . Negative_regulation CDK20 CDKN1C 15224347 1264957 The expression of ( Kip2 ) , a [cyclin dependent kinase] *inhibitor* that was also in the imprinted region , exhibited some variable increased expression predominantly in hepatic neoplasms from livers of female TG+ rats . Negative_regulation CDK20 CDKN1C 15537824 1367519 In contrast , EGCG accelerates terminal differentiation in normal human epidermal keratinocytes ( NHEK ) mediated partially by up-regulation of , a [cyclin dependent kinase] *inhibitor* that confers growth arrest and differentiation . Negative_regulation CDK20 CDKN1C 16731797 1566018 Differential expression of [cyclin dependent kinase] *inhibitors* , p27Kip1 and , by corticotropin in rat adrenal cortex . Negative_regulation CDK20 CDKN1C 16731797 1566056 An important role for the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p27Kip1 and , in the proliferation and differentiation of adrenal cells has been suggested by their knockout mice , which display adrenal hyperplasia . Negative_regulation CDK20 CDKN1C 18822693 1970546 The aim of this study was to establish the importance of , a unique [cyclin dependent kinase] *inhibitor* , in the oncogenesis of bladder carcinoma . Negative_regulation CDK20 CDKN1C 20503313 2263859 A small number of individuals with BWS ( 5-10 % ) have mutations in , a [cyclin dependent kinase] *inhibitor* of G1 cyclin complexes that functions as a negative regulator of cellular growth and proliferation . Negative_regulation CDK20 CDKN1C 21322636 2443315 p21 was found to be a key regulator of this process , because down-regulation of the [cyclin dependent kinase] *inhibitors* p27 ( CDKN1B/KIP1 ) or p57 ( ) or the tumor suppressor p53 ( TP53/LFS1 ) failed to induce proliferation and subsequent dedifferentiation . Negative_regulation CDK20 CDKN1C 22996691 2679059 Expression of , a BMP10 regulated [cyclin dependent kinase] *inhibitor* , was induced in Myocd-/- hearts , while BMP10 activated cardiogenic transcription factors , including NKX2.5 and MEF2c , were repressed . Negative_regulation CDK20 CDKN1C 7550351 323241 Genomic imprinting of , a [cyclin dependent kinase] *inhibitor* , in mouse . Negative_regulation CDK20 CDKN1C 7729683 302218 Cloning of , a [cyclin dependent kinase] *inhibitor* with unique domain structure and tissue distribution . Negative_regulation CDK20 CDKN1C 8923002 397223 The gene for insulin-like growth factor II (IGF2) is normally expressed from the paternal allele , while H19 and , a [cyclin dependent kinase] *inhibitor* , are expressed from the maternal allele . Negative_regulation CDK20 CDKN1C 9311734 455018 these include the gene for insulin-like growth factor II (IGF2) and H19 , which show abnormal imprint-specific expression and/or methylation in 20 % of BWS patients , and , a [cyclin dependent kinase] *inhibitor* , which we found showed biallelic expression in one of nine BWS patients studied . Negative_regulation CDK20 EPHB2 20855497 2325827 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Negative_regulation CDK20 EPHB2 21871886 2491308 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK20 IFI27 10198213 605050 73-kDa heat shock cognate protein interacts directly with , a [cyclin dependent kinase] *inhibitor* , during G1/S transition . Negative_regulation CDK20 IFI27 10198213 605088 In the present study , we demonstrated that 73hsc ( heat shock cognate protein ) , which belongs to the HSP70 family of molecular chaperones , interacts with , an *inhibitor* of [cyclin dependent kinase] , during G1/S transition . Negative_regulation CDK20 IFI27 10510349 651119 The treatment of macrophages with adenosine induces the expression of , a G1 [cyclin dependent kinase] *inhibitor* , in a protein kinase A-dependent way . Negative_regulation CDK20 IFI27 10859299 715254 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in many types of carcinomas . Negative_regulation CDK20 IFI27 10861499 705312 ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has an important role in the progression of cells from G ( 1 ) into S phase of the cell cycle . Negative_regulation CDK20 IFI27 10903892 713409 Minimal requirements for the nuclear localization of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK20 IFI27 11136238 786716 Previous work has shown that cyclin A can be cleaved at Arg-70/Arg-71 by a proteolytic activity present in an in vitro coupled transcription/translation system by using rabbit reticulocyte lysate programmed by plasmid DNA encoding ( KIP1 ) , a [cyclin dependent kinase] *inhibitor* , but not by plasmid DNAs encoding other cyclin dependent kinases inhibitors . Negative_regulation CDK20 IFI27 11164713 782673 [Cyclin dependent kinase] *inhibitors* , p21 ( waf1/cip1 ) and ( kip1 ) , are expressed site- and hair cycle-dependently in rat hair follicles . Negative_regulation CDK20 IFI27 11237531 790113 A major function of , also known as Kip1 , is to bind and *inhibit* [cyclin/cyclin dependent kinase] complexes , thereby blocking cell cycle progression . Negative_regulation CDK20 IFI27 11251953 793946 Low expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is a marker of poor prognosis in synovial sarcoma . Negative_regulation CDK20 IFI27 11251953 793965 Low expression of ( kip1 ) , a dominant [cyclin dependent kinase] *inhibitor* involved in G1-S transition of the cell cycle , recently has been reported to be associated with aggressive tumor growth . Negative_regulation CDK20 IFI27 11301477 803367 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in breast cancer . Negative_regulation CDK20 IFI27 11400230 824398 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , negatively regulates the G1 phase progression of the cell cycle by binding to the cyclin E/cyclin dependent kinase 2 complex . Negative_regulation CDK20 IFI27 11557117 861251 , a [cyclin dependent kinase] *inhibitor* , regulates the progression from G1 into the S phase by binding and inhibiting cyclin/cdks . Negative_regulation CDK20 IFI27 11744034 897896 Levels of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p16 and , were initially high in quiescent isolated cells and tissue ; Negative_regulation CDK20 IFI27 11745414 888966 Herein , expression of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p21 , and p57 and their associated kinase activities were examined in 61 cases of soft tissue smooth muscle tumors . Negative_regulation CDK20 IFI27 11850846 913196 LY294002 also causes an increase in , a [cyclin dependent kinase] *inhibitor* and results in the dephosphorylation of members of the pocket protein family . Negative_regulation CDK20 IFI27 11856766 914403 The differentiation was accompanied by a growth arrest and the upregulation of [cyclin dependent kinase] *inhibitors* , and p57 , as well as cyclin D(1) , whereas cyclin A was downregulated . Negative_regulation CDK20 IFI27 12097295 961276 Reduced expression level of , a [cyclin dependent kinase] *inhibitor* , is associated with high aggressiveness and poor prognosis of various malignant tumors , including gastric carcinoma . Negative_regulation CDK20 IFI27 12465754 1022267 Calcitriol induces a significant G0/G1 arrest and modulates p21 ( Waf/Cip1 ) and ( Kip1 ) , the [cyclin dependent kinase] *inhibitors* . Negative_regulation CDK20 IFI27 12663518 1074563 IP6 strongly increased the expression of CDKIs ( [cyclin dependent kinase] *inhibitors* ) , Cip1/p21 and , without any noticeable changes in G1 CDKs and cyclins , except a slight increase in cyclin D2 . Negative_regulation CDK20 IFI27 12771291 1094756 Parathyroid cell growth in patients with advanced secondary hyperparathyroidism : vitamin D receptor and [cyclin dependent kinase] *inhibitors* , p21 and . Negative_regulation CDK20 IFI27 12943995 1135805 We also observed a simultaneous increase in the expression of [cyclin-dependent-kinase] *inhibitors* , p21 , , p15 and p16 , associated with a loss in expression of Cyclin-A2 and Cyclin-E . Negative_regulation CDK20 IFI27 14618613 1188026 To examine the mechanism of the troglitazone induced growth inhibition , we determined ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , expression by Western blot analysis in troglitazone treated HLF cells . Negative_regulation CDK20 IFI27 15048878 1225258 We conclude that substrate dependent acquisition of proliferative phenotypes following repeated cycles of AAM injury correlates with modulation of the [cyclin dependent kinase] *inhibitors* , and p21 . Negative_regulation CDK20 IFI27 15138205 1246193 Gastric cells chronically exposed to H pylori in vitro develop resistance to apoptosis associated with low levels of , a [cyclin dependent kinase] *inhibitor* and haplo insufficient tumour suppressor gene that is downregulated in gastric cancer . Negative_regulation CDK20 IFI27 15224009 1264896 A high level of , an *inhibitor* of [cyclin dependent kinase] that correlates with the degree of in vitro apoptosis , is found in B-CLL cells . Negative_regulation CDK20 IFI27 15263796 1275077 The prognostic significance of cyclins D1 , E and [cyclin dependent kinase] *inhibitors* p21 ( Waf1/Cip1 ) , ( Kip1 ) in determining the risk of recurrence and progression with both univariate ( log rank test ) and multivariate ( Cox regression ) methods of analysis showed no statistically significance differences . Negative_regulation CDK20 IFI27 15378017 1324023 In the present study , we investigated the consequences of the combined loss of either of two [cyclin dependent kinase] *inhibitors* , p21 and , in cooperation with deletion of the INK4a/ARF locus . Negative_regulation CDK20 IFI27 15474987 1354684 Under the same conditions , adding MG or HK to VD3 or ATRA treatment further enlarged the G0/G1 cell population and increased the expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK20 IFI27 15491288 1321378 In addition , in myeloma cells subjected to growth-factor starvation , the upregulation of PGP9.5 was observed in association with that of ( Kip1 ) , a [cyclin-dependent-kinase] *inhibitor* , although the upregulation caused by irradiation was milder . Negative_regulation CDK20 IFI27 15799773 1390566 Several genes , including insulin-like growth factor 1 (IGF-1) and [cyclin dependent kinase] *inhibitor* ( ( Kip1 ) ) were induced by both injury types and these may have potential clinical application as markers of tissue damage . Negative_regulation CDK20 IFI27 15930262 1414429 Here , we found that VDUP1-/- fibroblast cells proliferated more rapidly compared with wild-type cells with reduced expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK20 IFI27 16020508 1465826 Tregs were blocked from cell cycle progression due to decrease of cyclin E and cyclin A and increase of ( p27kip [cyclin dependent kinase] *inhibitor* ) . Negative_regulation CDK20 IFI27 16039115 1473616 Levels of expression of cyclins , cyclin dependent kinases and [cyclin dependent kinase] *inhibitors* , p21 and , were analysed by western blotting . Negative_regulation CDK20 IFI27 16328436 1503626 [Cyclin dependent kinase] *inhibitors* CIP1 ( p21 ) and KIP1 ( ) in ovarian cancer . Negative_regulation CDK20 IFI27 16427178 1567182 In this study , under treatment with various concentrations of PA in MDA-MB 231 cell line , we checked mRNA levels for cyclin A and cyclin B1 and the protein levels of cyclin A and cyclin B1 , Cdc2 ( cyclin dependent kinases ) , p21 ( waf1/cip1 ) and ( Kip1 ) ( [cyclin dependent kinase] *inhibitors* ) , Cdc25C , Chk2 and Wee1 kinase ( cyclin dependent kinase relative factors ) in cell cycle G2/M phase . Negative_regulation CDK20 IFI27 16436005 1495310 ( kip1 ) , a universal [cyclin dependent kinase] *inhibitor* , is a useful marker for predicting clinical aggressiveness with various human tumors . Negative_regulation CDK20 IFI27 16564150 1555723 In contrast , protein levels of , a [cyclin dependent kinase] *inhibitor* , are increased after induction of ER-stress using tunicamycin . Negative_regulation CDK20 IFI27 17360552 1712765 As proof of principle , we studied the consequence of sporadic loss of , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK20 IFI27 17918155 1843884 Furthermore , we find that the growth inhibitory dose of R1881 leads to increases in the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21 and as well as to G1 arrest . Negative_regulation CDK20 IFI27 17979972 1874287 Terrein was found to downregulate cyclin B1 and Cdc2 without Cdc2 phosphorylation , but upregulated ( KIP1 ) ( p27 ) , a known *inhibitor* of [cyclin dependent kinase] . Negative_regulation CDK20 IFI27 18583941 1953331 Roles of [cyclin dependent kinase] *inhibitors* , p21/Cip1 ( p21 ) and p27/Kip1 ( ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation CDK20 IFI27 19026637 2022731 Activation of ERK1/2 was not affected by MacCM , and neither was the expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK20 IFI27 19147535 2026290 Two [cyclin dependent kinase] *inhibitors* , p18 ( Ink4c ) and ( Kip1 ) , are required for proper cerebellar development . Negative_regulation CDK20 IFI27 19276255 2046196 In retrospective studies , loss of ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has been associated with poor prognosis following colorectal cancer treatment . Negative_regulation CDK20 IFI27 19321452 2073941 Although HSC70 directly bound to ( Kip1 ) ( a [cyclin dependent kinase] *inhibitor* ) , histatin 3 increased the binding between those proteins but not with a peptide capable of binding to HSC70 . Negative_regulation CDK20 IFI27 19538337 2103580 In this study , we examined the role of melatonin on synoviocyte proliferation in primary cultured human fibroblast-like synoviocytes ( FLSs ) by analyzing protein expression of P21 ( CIP1 ) ( P21 ) and ( KIP1 ) ( P27 ) , the [cyclin dependent kinase] *inhibitors* that are important in cell cycle control , and the phosphorylation of mitogen activated protein kinases ( MAPKs ) . Negative_regulation CDK20 IFI27 19598246 2149819 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is also known to demarcate the prosensory region in the cochlear primordium , which consists of the sensory progenitors that have completed their terminal mitoses . Negative_regulation CDK20 IFI27 19720293 2133712 Trastuzumab , a humanized antibody directed against the Her2 receptor , induces the expression of ( kip1 ) , an intranuclear [cyclin dependent kinase] *inhibitor* in some breast cancer cells . Negative_regulation CDK20 IFI27 21443540 2438450 Furthermore , NS expression was associated with cellular proliferation in OSCC cell lines using siRNA , which upregulated , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK20 IFI27 21980125 2502937 Further , deletion of AMPKa2 but not AMPKa1 reduced the level of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , and increased the level of S-phase kinase associated protein 2 ( Skp2 ) , a known E3 ubiquitin ligase for p27 ( Kip1 ) , through activation of p52 nuclear factor kappa B ( NF-?B ) -2 . Negative_regulation CDK20 IFI27 22154697 2563126 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) of the CIP/KIP family , p21 , and p57 , mediate cell cycle inhibition . Negative_regulation CDK20 IFI27 22460505 2637138 Cell cycle analysis indicated thioridazine induced the down-regulation of cyclin D1 , cyclin A and CDK4 , and the induction of p21 and , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK20 IFI27 22851678 2677209 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , ( Kip1 ) , and cyclin D1 . Negative_regulation CDK20 IFI27 23255047 2827362 Skp2 mediated degradation of , a [cyclin dependent kinase] *inhibitor* , is involved in cell cycle regulation . Negative_regulation CDK20 IFI27 23721824 2819718 miR-370 induced proliferation was correlated with the downregulation of [cyclin dependent kinase] *inhibitors* , ( Kip1 ) and p21 ( Cip1 ) , and the upregulation of the cell cycle regulator cyclin D1 . Negative_regulation CDK20 IFI27 23888319 2902009 Our results found that curcumin inhibited cell proliferation , which was associated with upregulation of the [cyclin dependent kinase] *inhibitors* , and p21 , and downregulation of cyclin D1 . Negative_regulation CDK20 IFI27 23944957 2887982 We determined whether proliferation and IL-6 release are abnormal in ASM cells ( ASMCs ) from patients with severe asthma , and whether these features could be mediated by microRNA-221 and microRNA-222 , through modulation of the [cyclin dependent kinase] *inhibitors* , p21 ( WAF1 ) and ( kip1 ) . Negative_regulation CDK20 IFI27 24067984 2867175 Western blot analysis of key cell cycle regulators revealed that K-Rta mediated cell cycle arrest was associated with a decrease in cyclin A and phosphorylated Rb ( pS807/pS811 ) protein levels , both markers of S phase progression , and an increase in protein levels for , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK20 IFI27 24708177 2938877 Recently , STMN1 was reported to interact with , an *inhibitor* of [cyclin dependent kinase] complexes . Negative_regulation CDK20 IFI27 8654372 366884 Expression of Zta results in induction of the tumor suppressor protein , p53 , and the [cyclin dependent kinase] *inhibitors* , p21 and , as well as accumulation of hypophosphorylated pRb . Negative_regulation CDK20 IFI27 8845296 337844 We have examined the level of cyclin E , a G1 cyclin , and , a [cyclin dependent kinase] *inhibitor* , in BALB/c 3T3 cells . Negative_regulation CDK20 IFI27 9616167 509588 The identification of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* that contributes to cell cycle arrest and represents a link between extracellular signals and cell cycle , prompted us to study p27 protein in the lymphocytes from 88 patients with B-CLL and 32 patients with other chronic B-lymphoproliferative disorders . Negative_regulation CDK20 IFI27 9746784 533002 The ( kip-1 ) , a [cyclin dependent kinase] *inhibitor* which is important in blocking the cell cycle , was induced more quickly and potently by Ro 25-9716 ( 10 ( -7 ) mol/L , 0 to 5 days ) than by 1,25D3 , suggesting a possible mechanism by which these analogs inhibit proliferation of leukemic growth . Negative_regulation CDK20 IFI27 9891946 558582 Hence , we have determined the cell cycle profile , expressions and activities of the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21CIP1 and , during rat ventricular myocyte development . Negative_regulation CDK20 ITGA9 22138449 2536220 Furthermore , effects of p21 , a [cyclin dependent kinase] *inhibitor* , and integrin a9 ( ) were examined . Negative_regulation CDK20 MAP2K6 10597223 573462 p21Cip1/Waf1 [cyclin dependent kinase] inhibitor ( p21 ) is *inducible* by Raf and ( MAPKK ) , but the level of regulation is unknown . Negative_regulation CDK20 MAP2K6 21871886 2491314 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK20 RARB 21868513 2473729 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Negative_regulation CDK3 CCND1 22851678 2677183 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , p27 ( Kip1 ) , and . Negative_regulation CDK3 CCND1 24399246 2906970 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) ( p21Cip1 , p27Kip1 , p15INK4B ) , and cyclin E were shown to be differentially expressed in latexin overexpressed cells and latexin silenced cells . Negative_regulation CDK3 CDKN1C 11347369 814328 The expression of , a [cyclin dependent kinase] *inhibitor* , is a strong indicator that the cells are exiting the cell cycle and are beginning to differentiate . Negative_regulation CDK3 CDKN1C 11529881 853609 We examine the cell proliferation activity and expression of [cyclin dependent kinase] *inhibitors* of the Cip/Kip family , p21Cip1 , p27Kip1 and , in foetal hamster lungs to determine the expression patterns of the cyclin dependent kinase inhibitors and to clarify the relationship between expression of the cyclin dependent kinase inhibitors and lung development . Negative_regulation CDK3 CDKN1C 15224347 1264949 The expression of ( Kip2 ) , a [cyclin dependent kinase] *inhibitor* that was also in the imprinted region , exhibited some variable increased expression predominantly in hepatic neoplasms from livers of female TG+ rats . Negative_regulation CDK3 CDKN1C 15537824 1367511 In contrast , EGCG accelerates terminal differentiation in normal human epidermal keratinocytes ( NHEK ) mediated partially by up-regulation of , a [cyclin dependent kinase] *inhibitor* that confers growth arrest and differentiation . Negative_regulation CDK3 CDKN1C 16731797 1566002 Differential expression of [cyclin dependent kinase] *inhibitors* , p27Kip1 and , by corticotropin in rat adrenal cortex . Negative_regulation CDK3 CDKN1C 16731797 1566040 An important role for the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p27Kip1 and , in the proliferation and differentiation of adrenal cells has been suggested by their knockout mice , which display adrenal hyperplasia . Negative_regulation CDK3 CDKN1C 18822693 1970538 The aim of this study was to establish the importance of , a unique [cyclin dependent kinase] *inhibitor* , in the oncogenesis of bladder carcinoma . Negative_regulation CDK3 CDKN1C 20503313 2263851 A small number of individuals with BWS ( 5-10 % ) have mutations in , a [cyclin dependent kinase] *inhibitor* of G1 cyclin complexes that functions as a negative regulator of cellular growth and proliferation . Negative_regulation CDK3 CDKN1C 21322636 2443299 p21 was found to be a key regulator of this process , because down-regulation of the [cyclin dependent kinase] *inhibitors* p27 ( CDKN1B/KIP1 ) or p57 ( ) or the tumor suppressor p53 ( TP53/LFS1 ) failed to induce proliferation and subsequent dedifferentiation . Negative_regulation CDK3 CDKN1C 22996691 2679051 Expression of , a BMP10 regulated [cyclin dependent kinase] *inhibitor* , was induced in Myocd-/- hearts , while BMP10 activated cardiogenic transcription factors , including NKX2.5 and MEF2c , were repressed . Negative_regulation CDK3 CDKN1C 7550351 323233 Genomic imprinting of , a [cyclin dependent kinase] *inhibitor* , in mouse . Negative_regulation CDK3 CDKN1C 7729683 302210 Cloning of , a [cyclin dependent kinase] *inhibitor* with unique domain structure and tissue distribution . Negative_regulation CDK3 CDKN1C 8923002 397207 The gene for insulin-like growth factor II (IGF2) is normally expressed from the paternal allele , while H19 and , a [cyclin dependent kinase] *inhibitor* , are expressed from the maternal allele . Negative_regulation CDK3 CDKN1C 9311734 455010 these include the gene for insulin-like growth factor II (IGF2) and H19 , which show abnormal imprint-specific expression and/or methylation in 20 % of BWS patients , and , a [cyclin dependent kinase] *inhibitor* , which we found showed biallelic expression in one of nine BWS patients studied . Negative_regulation CDK3 EPHB2 20855497 2325801 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Negative_regulation CDK3 EPHB2 21871886 2491210 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK3 IFI27 10198213 605034 73-kDa heat shock cognate protein interacts directly with , a [cyclin dependent kinase] *inhibitor* , during G1/S transition . Negative_regulation CDK3 IFI27 10198213 605072 In the present study , we demonstrated that 73hsc ( heat shock cognate protein ) , which belongs to the HSP70 family of molecular chaperones , interacts with , an *inhibitor* of [cyclin dependent kinase] , during G1/S transition . Negative_regulation CDK3 IFI27 10510349 651103 The treatment of macrophages with adenosine induces the expression of , a G1 [cyclin dependent kinase] *inhibitor* , in a protein kinase A-dependent way . Negative_regulation CDK3 IFI27 10859299 715246 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in many types of carcinomas . Negative_regulation CDK3 IFI27 10861499 705304 ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has an important role in the progression of cells from G ( 1 ) into S phase of the cell cycle . Negative_regulation CDK3 IFI27 10903892 713401 Minimal requirements for the nuclear localization of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK3 IFI27 11136238 786708 Previous work has shown that cyclin A can be cleaved at Arg-70/Arg-71 by a proteolytic activity present in an in vitro coupled transcription/translation system by using rabbit reticulocyte lysate programmed by plasmid DNA encoding ( KIP1 ) , a [cyclin dependent kinase] *inhibitor* , but not by plasmid DNAs encoding other cyclin dependent kinases inhibitors . Negative_regulation CDK3 IFI27 11164713 782657 [Cyclin dependent kinase] *inhibitors* , p21 ( waf1/cip1 ) and ( kip1 ) , are expressed site- and hair cycle-dependently in rat hair follicles . Negative_regulation CDK3 IFI27 11237531 790105 A major function of , also known as Kip1 , is to bind and *inhibit* [cyclin/cyclin dependent kinase] complexes , thereby blocking cell cycle progression . Negative_regulation CDK3 IFI27 11251953 793938 Low expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is a marker of poor prognosis in synovial sarcoma . Negative_regulation CDK3 IFI27 11251953 793957 Low expression of ( kip1 ) , a dominant [cyclin dependent kinase] *inhibitor* involved in G1-S transition of the cell cycle , recently has been reported to be associated with aggressive tumor growth . Negative_regulation CDK3 IFI27 11301477 803359 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in breast cancer . Negative_regulation CDK3 IFI27 11400230 824390 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , negatively regulates the G1 phase progression of the cell cycle by binding to the cyclin E/cyclin dependent kinase 2 complex . Negative_regulation CDK3 IFI27 11557117 861243 , a [cyclin dependent kinase] *inhibitor* , regulates the progression from G1 into the S phase by binding and inhibiting cyclin/cdks . Negative_regulation CDK3 IFI27 11744034 897888 Levels of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p16 and , were initially high in quiescent isolated cells and tissue ; Negative_regulation CDK3 IFI27 11745414 888958 Herein , expression of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p21 , and p57 and their associated kinase activities were examined in 61 cases of soft tissue smooth muscle tumors . Negative_regulation CDK3 IFI27 11850846 913180 LY294002 also causes an increase in , a [cyclin dependent kinase] *inhibitor* and results in the dephosphorylation of members of the pocket protein family . Negative_regulation CDK3 IFI27 11856766 914395 The differentiation was accompanied by a growth arrest and the upregulation of [cyclin dependent kinase] *inhibitors* , and p57 , as well as cyclin D(1) , whereas cyclin A was downregulated . Negative_regulation CDK3 IFI27 12097295 961268 Reduced expression level of , a [cyclin dependent kinase] *inhibitor* , is associated with high aggressiveness and poor prognosis of various malignant tumors , including gastric carcinoma . Negative_regulation CDK3 IFI27 12465754 1022251 Calcitriol induces a significant G0/G1 arrest and modulates p21 ( Waf/Cip1 ) and ( Kip1 ) , the [cyclin dependent kinase] *inhibitors* . Negative_regulation CDK3 IFI27 12663518 1074531 IP6 strongly increased the expression of CDKIs ( [cyclin dependent kinase] *inhibitors* ) , Cip1/p21 and , without any noticeable changes in G1 CDKs and cyclins , except a slight increase in cyclin D2 . Negative_regulation CDK3 IFI27 12771291 1094740 Parathyroid cell growth in patients with advanced secondary hyperparathyroidism : vitamin D receptor and [cyclin dependent kinase] *inhibitors* , p21 and . Negative_regulation CDK3 IFI27 12943995 1135789 We also observed a simultaneous increase in the expression of [cyclin-dependent-kinase] *inhibitors* , p21 , , p15 and p16 , associated with a loss in expression of Cyclin-A2 and Cyclin-E . Negative_regulation CDK3 IFI27 14618613 1188018 To examine the mechanism of the troglitazone induced growth inhibition , we determined ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , expression by Western blot analysis in troglitazone treated HLF cells . Negative_regulation CDK3 IFI27 15048878 1225242 We conclude that substrate dependent acquisition of proliferative phenotypes following repeated cycles of AAM injury correlates with modulation of the [cyclin dependent kinase] *inhibitors* , and p21 . Negative_regulation CDK3 IFI27 15138205 1246185 Gastric cells chronically exposed to H pylori in vitro develop resistance to apoptosis associated with low levels of , a [cyclin dependent kinase] *inhibitor* and haplo insufficient tumour suppressor gene that is downregulated in gastric cancer . Negative_regulation CDK3 IFI27 15224009 1264880 A high level of , an *inhibitor* of [cyclin dependent kinase] that correlates with the degree of in vitro apoptosis , is found in B-CLL cells . Negative_regulation CDK3 IFI27 15263796 1275069 The prognostic significance of cyclins D1 , E and [cyclin dependent kinase] *inhibitors* p21 ( Waf1/Cip1 ) , ( Kip1 ) in determining the risk of recurrence and progression with both univariate ( log rank test ) and multivariate ( Cox regression ) methods of analysis showed no statistically significance differences . Negative_regulation CDK3 IFI27 15378017 1324007 In the present study , we investigated the consequences of the combined loss of either of two [cyclin dependent kinase] *inhibitors* , p21 and , in cooperation with deletion of the INK4a/ARF locus . Negative_regulation CDK3 IFI27 15474987 1354676 Under the same conditions , adding MG or HK to VD3 or ATRA treatment further enlarged the G0/G1 cell population and increased the expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK3 IFI27 15491288 1321370 In addition , in myeloma cells subjected to growth-factor starvation , the upregulation of PGP9.5 was observed in association with that of ( Kip1 ) , a [cyclin-dependent-kinase] *inhibitor* , although the upregulation caused by irradiation was milder . Negative_regulation CDK3 IFI27 15799773 1390558 Several genes , including insulin-like growth factor 1 (IGF-1) and [cyclin dependent kinase] *inhibitor* ( ( Kip1 ) ) were induced by both injury types and these may have potential clinical application as markers of tissue damage . Negative_regulation CDK3 IFI27 15930262 1414421 Here , we found that VDUP1-/- fibroblast cells proliferated more rapidly compared with wild-type cells with reduced expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK3 IFI27 16020508 1465810 Tregs were blocked from cell cycle progression due to decrease of cyclin E and cyclin A and increase of ( p27kip [cyclin dependent kinase] *inhibitor* ) . Negative_regulation CDK3 IFI27 16039115 1473600 Levels of expression of cyclins , cyclin dependent kinases and [cyclin dependent kinase] *inhibitors* , p21 and , were analysed by western blotting . Negative_regulation CDK3 IFI27 16328436 1503618 [Cyclin dependent kinase] *inhibitors* CIP1 ( p21 ) and KIP1 ( ) in ovarian cancer . Negative_regulation CDK3 IFI27 16427178 1567166 In this study , under treatment with various concentrations of PA in MDA-MB 231 cell line , we checked mRNA levels for cyclin A and cyclin B1 and the protein levels of cyclin A and cyclin B1 , Cdc2 ( cyclin dependent kinases ) , p21 ( waf1/cip1 ) and ( Kip1 ) ( [cyclin dependent kinase] *inhibitors* ) , Cdc25C , Chk2 and Wee1 kinase ( cyclin dependent kinase relative factors ) in cell cycle G2/M phase . Negative_regulation CDK3 IFI27 16436005 1495302 ( kip1 ) , a universal [cyclin dependent kinase] *inhibitor* , is a useful marker for predicting clinical aggressiveness with various human tumors . Negative_regulation CDK3 IFI27 16564150 1555715 In contrast , protein levels of , a [cyclin dependent kinase] *inhibitor* , are increased after induction of ER-stress using tunicamycin . Negative_regulation CDK3 IFI27 17360552 1712749 As proof of principle , we studied the consequence of sporadic loss of , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK3 IFI27 17918155 1843868 Furthermore , we find that the growth inhibitory dose of R1881 leads to increases in the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21 and as well as to G1 arrest . Negative_regulation CDK3 IFI27 17979972 1874279 Terrein was found to downregulate cyclin B1 and Cdc2 without Cdc2 phosphorylation , but upregulated ( KIP1 ) ( p27 ) , a known *inhibitor* of [cyclin dependent kinase] . Negative_regulation CDK3 IFI27 18583941 1953297 Roles of [cyclin dependent kinase] *inhibitors* , p21/Cip1 ( p21 ) and p27/Kip1 ( ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation CDK3 IFI27 19026637 2022723 Activation of ERK1/2 was not affected by MacCM , and neither was the expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK3 IFI27 19147535 2026274 Two [cyclin dependent kinase] *inhibitors* , p18 ( Ink4c ) and ( Kip1 ) , are required for proper cerebellar development . Negative_regulation CDK3 IFI27 19276255 2046188 In retrospective studies , loss of ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has been associated with poor prognosis following colorectal cancer treatment . Negative_regulation CDK3 IFI27 19321452 2073933 Although HSC70 directly bound to ( Kip1 ) ( a [cyclin dependent kinase] *inhibitor* ) , histatin 3 increased the binding between those proteins but not with a peptide capable of binding to HSC70 . Negative_regulation CDK3 IFI27 19538337 2103564 In this study , we examined the role of melatonin on synoviocyte proliferation in primary cultured human fibroblast-like synoviocytes ( FLSs ) by analyzing protein expression of P21 ( CIP1 ) ( P21 ) and ( KIP1 ) ( P27 ) , the [cyclin dependent kinase] *inhibitors* that are important in cell cycle control , and the phosphorylation of mitogen activated protein kinases ( MAPKs ) . Negative_regulation CDK3 IFI27 19598246 2149811 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is also known to demarcate the prosensory region in the cochlear primordium , which consists of the sensory progenitors that have completed their terminal mitoses . Negative_regulation CDK3 IFI27 19720293 2133704 Trastuzumab , a humanized antibody directed against the Her2 receptor , induces the expression of ( kip1 ) , an intranuclear [cyclin dependent kinase] *inhibitor* in some breast cancer cells . Negative_regulation CDK3 IFI27 21443540 2438442 Furthermore , NS expression was associated with cellular proliferation in OSCC cell lines using siRNA , which upregulated , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK3 IFI27 21980125 2502929 Further , deletion of AMPKa2 but not AMPKa1 reduced the level of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , and increased the level of S-phase kinase associated protein 2 ( Skp2 ) , a known E3 ubiquitin ligase for p27 ( Kip1 ) , through activation of p52 nuclear factor kappa B ( NF-?B ) -2 . Negative_regulation CDK3 IFI27 22154697 2563118 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) of the CIP/KIP family , p21 , and p57 , mediate cell cycle inhibition . Negative_regulation CDK3 IFI27 22460505 2637122 Cell cycle analysis indicated thioridazine induced the down-regulation of cyclin D1 , cyclin A and CDK4 , and the induction of p21 and , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK3 IFI27 22851678 2677185 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , ( Kip1 ) , and cyclin D1 . Negative_regulation CDK3 IFI27 23255047 2827354 Skp2 mediated degradation of , a [cyclin dependent kinase] *inhibitor* , is involved in cell cycle regulation . Negative_regulation CDK3 IFI27 23721824 2819702 miR-370 induced proliferation was correlated with the downregulation of [cyclin dependent kinase] *inhibitors* , ( Kip1 ) and p21 ( Cip1 ) , and the upregulation of the cell cycle regulator cyclin D1 . Negative_regulation CDK3 IFI27 23888319 2901993 Our results found that curcumin inhibited cell proliferation , which was associated with upregulation of the [cyclin dependent kinase] *inhibitors* , and p21 , and downregulation of cyclin D1 . Negative_regulation CDK3 IFI27 23944957 2887966 We determined whether proliferation and IL-6 release are abnormal in ASM cells ( ASMCs ) from patients with severe asthma , and whether these features could be mediated by microRNA-221 and microRNA-222 , through modulation of the [cyclin dependent kinase] *inhibitors* , p21 ( WAF1 ) and ( kip1 ) . Negative_regulation CDK3 IFI27 24067984 2867167 Western blot analysis of key cell cycle regulators revealed that K-Rta mediated cell cycle arrest was associated with a decrease in cyclin A and phosphorylated Rb ( pS807/pS811 ) protein levels , both markers of S phase progression , and an increase in protein levels for , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK3 IFI27 24708177 2938869 Recently , STMN1 was reported to interact with , an *inhibitor* of [cyclin dependent kinase] complexes . Negative_regulation CDK3 IFI27 8654372 366868 Expression of Zta results in induction of the tumor suppressor protein , p53 , and the [cyclin dependent kinase] *inhibitors* , p21 and , as well as accumulation of hypophosphorylated pRb . Negative_regulation CDK3 IFI27 8845296 337820 We have examined the level of cyclin E , a G1 cyclin , and , a [cyclin dependent kinase] *inhibitor* , in BALB/c 3T3 cells . Negative_regulation CDK3 IFI27 9616167 509580 The identification of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* that contributes to cell cycle arrest and represents a link between extracellular signals and cell cycle , prompted us to study p27 protein in the lymphocytes from 88 patients with B-CLL and 32 patients with other chronic B-lymphoproliferative disorders . Negative_regulation CDK3 IFI27 9746784 532994 The ( kip-1 ) , a [cyclin dependent kinase] *inhibitor* which is important in blocking the cell cycle , was induced more quickly and potently by Ro 25-9716 ( 10 ( -7 ) mol/L , 0 to 5 days ) than by 1,25D3 , suggesting a possible mechanism by which these analogs inhibit proliferation of leukemic growth . Negative_regulation CDK3 IFI27 9891946 558550 Hence , we have determined the cell cycle profile , expressions and activities of the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21CIP1 and , during rat ventricular myocyte development . Negative_regulation CDK3 ITGA9 22138449 2536212 Furthermore , effects of p21 , a [cyclin dependent kinase] *inhibitor* , and integrin a9 ( ) were examined . Negative_regulation CDK3 MAP2K6 10597223 573391 p21Cip1/Waf1 [cyclin dependent kinase] inhibitor ( p21 ) is *inducible* by Raf and ( MAPKK ) , but the level of regulation is unknown . Negative_regulation CDK3 MAP2K6 21871886 2491216 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK3 RARB 21868513 2473721 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Negative_regulation CDK4 CCND1 10585273 571105 Complex mechanisms underlying impaired *activation* of [Cdk4] and Cdk2 in replicative senescence : roles of p16 , p21 , and . Negative_regulation CDK4 CCND1 15743831 1379098 In this report , we show that adenovirus mediated expression of merlin in NF2-deficient tumor cells inhibits cell proliferation and arrests cells at G1 phase , concomitant with decreased expression of , *inhibition* of [CDK4] activity , and dephosphorylation of pRB . Negative_regulation CDK4 CCND1 16406622 1527155 The inhibition of expression and the *inhibition* of [CDK4] expression significantly impaired the B ( a ) P-induced overexpression of E2F-1 respectively . Negative_regulation CDK4 CCND1 19806481 2299381 p16 could specifically interact with to *inhibit* the activity of [cyclin dependent kinase 4] . Negative_regulation CDK4 CCND1 20813136 2341765 PMA also increased expression and *inhibition* of cyclin [D1/CDK4] complex and the cell cycle reduced BK virus infection . Negative_regulation CDK4 CCND1 20816752 2324986 Analysis of G1 cell cycle regulators expression revealed 2M4VP increased expression of CDK inhibitor , p21Waf1/Cip1 and p15 INK4b , decreased expression of and cyclin E , and *inhibited* kinase activities of [CDK4] and CDK2 . Negative_regulation CDK4 CCND1 22851678 2677186 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , p27 ( Kip1 ) , and . Negative_regulation CDK4 CCND1 24399246 2906971 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) ( p21Cip1 , p27Kip1 , p15INK4B ) , and cyclin E were shown to be differentially expressed in latexin overexpressed cells and latexin silenced cells . Negative_regulation CDK4 CCND1 9169494 432866 overexpression *resulted* in a concomitant increase in [CDK4] levels in the adult myocardium , as well as modest increases in proliferating cell nuclear antigen and CDK2 levels . Negative_regulation CDK4 CCND1 9815758 479564 Despite the continued presence of antiestrogen , induction *resulted* in the formation of active cyclin [D1/Cdk4] complexes , concurrent hyperphosphorylation of the retinoblastoma protein , and entry into S phase of cells previously arrested in G1 . Negative_regulation CDK4 CDKN1C 11347369 814329 The expression of , a [cyclin dependent kinase] *inhibitor* , is a strong indicator that the cells are exiting the cell cycle and are beginning to differentiate . Negative_regulation CDK4 CDKN1C 11529881 853612 We examine the cell proliferation activity and expression of [cyclin dependent kinase] *inhibitors* of the Cip/Kip family , p21Cip1 , p27Kip1 and , in foetal hamster lungs to determine the expression patterns of the cyclin dependent kinase inhibitors and to clarify the relationship between expression of the cyclin dependent kinase inhibitors and lung development . Negative_regulation CDK4 CDKN1C 15224347 1264950 The expression of ( Kip2 ) , a [cyclin dependent kinase] *inhibitor* that was also in the imprinted region , exhibited some variable increased expression predominantly in hepatic neoplasms from livers of female TG+ rats . Negative_regulation CDK4 CDKN1C 15537824 1367512 In contrast , EGCG accelerates terminal differentiation in normal human epidermal keratinocytes ( NHEK ) mediated partially by up-regulation of , a [cyclin dependent kinase] *inhibitor* that confers growth arrest and differentiation . Negative_regulation CDK4 CDKN1C 15821902 1403863 [CDK4] activity is *inhibited* by , which is regulated by insulin . Negative_regulation CDK4 CDKN1C 16731797 1566004 Differential expression of [cyclin dependent kinase] *inhibitors* , p27Kip1 and , by corticotropin in rat adrenal cortex . Negative_regulation CDK4 CDKN1C 16731797 1566042 An important role for the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p27Kip1 and , in the proliferation and differentiation of adrenal cells has been suggested by their knockout mice , which display adrenal hyperplasia . Negative_regulation CDK4 CDKN1C 18822693 1970539 The aim of this study was to establish the importance of , a unique [cyclin dependent kinase] *inhibitor* , in the oncogenesis of bladder carcinoma . Negative_regulation CDK4 CDKN1C 20503313 2263852 A small number of individuals with BWS ( 5-10 % ) have mutations in , a [cyclin dependent kinase] *inhibitor* of G1 cyclin complexes that functions as a negative regulator of cellular growth and proliferation . Negative_regulation CDK4 CDKN1C 21322636 2443301 p21 was found to be a key regulator of this process , because down-regulation of the [cyclin dependent kinase] *inhibitors* p27 ( CDKN1B/KIP1 ) or p57 ( ) or the tumor suppressor p53 ( TP53/LFS1 ) failed to induce proliferation and subsequent dedifferentiation . Negative_regulation CDK4 CDKN1C 22996691 2679052 Expression of , a BMP10 regulated [cyclin dependent kinase] *inhibitor* , was induced in Myocd-/- hearts , while BMP10 activated cardiogenic transcription factors , including NKX2.5 and MEF2c , were repressed . Negative_regulation CDK4 CDKN1C 7550351 323234 Genomic imprinting of , a [cyclin dependent kinase] *inhibitor* , in mouse . Negative_regulation CDK4 CDKN1C 7729683 302211 Cloning of , a [cyclin dependent kinase] *inhibitor* with unique domain structure and tissue distribution . Negative_regulation CDK4 CDKN1C 8923002 397209 The gene for insulin-like growth factor II (IGF2) is normally expressed from the paternal allele , while H19 and , a [cyclin dependent kinase] *inhibitor* , are expressed from the maternal allele . Negative_regulation CDK4 CDKN1C 9311734 455011 these include the gene for insulin-like growth factor II (IGF2) and H19 , which show abnormal imprint-specific expression and/or methylation in 20 % of BWS patients , and , a [cyclin dependent kinase] *inhibitor* , which we found showed biallelic expression in one of nine BWS patients studied . Negative_regulation CDK4 EPHB2 20855497 2325804 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Negative_regulation CDK4 EPHB2 21871886 2491220 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK4 IFI27 10198213 605036 73-kDa heat shock cognate protein interacts directly with , a [cyclin dependent kinase] *inhibitor* , during G1/S transition . Negative_regulation CDK4 IFI27 10198213 605074 In the present study , we demonstrated that 73hsc ( heat shock cognate protein ) , which belongs to the HSP70 family of molecular chaperones , interacts with , an *inhibitor* of [cyclin dependent kinase] , during G1/S transition . Negative_regulation CDK4 IFI27 10510349 651105 The treatment of macrophages with adenosine induces the expression of , a G1 [cyclin dependent kinase] *inhibitor* , in a protein kinase A-dependent way . Negative_regulation CDK4 IFI27 10713180 675915 In contrast , cyclin [D-Cdk4] was not *inhibited* by His ( 6 ) <-p27> in vitro or p27 ( Kip1 ) in vivo . Negative_regulation CDK4 IFI27 10859299 715247 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in many types of carcinomas . Negative_regulation CDK4 IFI27 10861499 705305 ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has an important role in the progression of cells from G ( 1 ) into S phase of the cell cycle . Negative_regulation CDK4 IFI27 10903892 713402 Minimal requirements for the nuclear localization of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK4 IFI27 11136238 786709 Previous work has shown that cyclin A can be cleaved at Arg-70/Arg-71 by a proteolytic activity present in an in vitro coupled transcription/translation system by using rabbit reticulocyte lysate programmed by plasmid DNA encoding ( KIP1 ) , a [cyclin dependent kinase] *inhibitor* , but not by plasmid DNAs encoding other cyclin dependent kinases inhibitors . Negative_regulation CDK4 IFI27 11164713 782659 [Cyclin dependent kinase] *inhibitors* , p21 ( waf1/cip1 ) and ( kip1 ) , are expressed site- and hair cycle-dependently in rat hair follicles . Negative_regulation CDK4 IFI27 11237531 790106 A major function of , also known as Kip1 , is to bind and *inhibit* [cyclin/cyclin dependent kinase] complexes , thereby blocking cell cycle progression . Negative_regulation CDK4 IFI27 11251953 793939 Low expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is a marker of poor prognosis in synovial sarcoma . Negative_regulation CDK4 IFI27 11251953 793958 Low expression of ( kip1 ) , a dominant [cyclin dependent kinase] *inhibitor* involved in G1-S transition of the cell cycle , recently has been reported to be associated with aggressive tumor growth . Negative_regulation CDK4 IFI27 11301477 803360 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in breast cancer . Negative_regulation CDK4 IFI27 11400230 824391 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , negatively regulates the G1 phase progression of the cell cycle by binding to the cyclin E/cyclin dependent kinase 2 complex . Negative_regulation CDK4 IFI27 11557117 861244 , a [cyclin dependent kinase] *inhibitor* , regulates the progression from G1 into the S phase by binding and inhibiting cyclin/cdks . Negative_regulation CDK4 IFI27 11744034 897889 Levels of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p16 and , were initially high in quiescent isolated cells and tissue ; Negative_regulation CDK4 IFI27 11745414 888959 Herein , expression of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p21 , and p57 and their associated kinase activities were examined in 61 cases of soft tissue smooth muscle tumors . Negative_regulation CDK4 IFI27 11850846 913182 LY294002 also causes an increase in , a [cyclin dependent kinase] *inhibitor* and results in the dephosphorylation of members of the pocket protein family . Negative_regulation CDK4 IFI27 11856766 914396 The differentiation was accompanied by a growth arrest and the upregulation of [cyclin dependent kinase] *inhibitors* , and p57 , as well as cyclin D(1) , whereas cyclin A was downregulated . Negative_regulation CDK4 IFI27 12097295 961269 Reduced expression level of , a [cyclin dependent kinase] *inhibitor* , is associated with high aggressiveness and poor prognosis of various malignant tumors , including gastric carcinoma . Negative_regulation CDK4 IFI27 12465754 1022253 Calcitriol induces a significant G0/G1 arrest and modulates p21 ( Waf/Cip1 ) and ( Kip1 ) , the [cyclin dependent kinase] *inhibitors* . Negative_regulation CDK4 IFI27 12663518 1074535 IP6 strongly increased the expression of CDKIs ( [cyclin dependent kinase] *inhibitors* ) , Cip1/p21 and , without any noticeable changes in G1 CDKs and cyclins , except a slight increase in cyclin D2 . Negative_regulation CDK4 IFI27 12771291 1094742 Parathyroid cell growth in patients with advanced secondary hyperparathyroidism : vitamin D receptor and [cyclin dependent kinase] *inhibitors* , p21 and . Negative_regulation CDK4 IFI27 12943995 1135791 We also observed a simultaneous increase in the expression of [cyclin-dependent-kinase] *inhibitors* , p21 , , p15 and p16 , associated with a loss in expression of Cyclin-A2 and Cyclin-E . Negative_regulation CDK4 IFI27 14597415 1160650 In the presence of TSH , transforming growth factor beta ( TGFbeta ) did not affect the assembly of cyclin D3-CDK4 , but it strongly inhibited the pRb-kinase activity associated with both cyclin D3 and p27 , not only by preventing the nuclear import of cyclin D3-CDK4 and its binding to , but also by *inhibiting* [CDK4] phosphorylation within residual p27 bound cyclin D3-CDK4 complexes . Negative_regulation CDK4 IFI27 14618613 1188019 To examine the mechanism of the troglitazone induced growth inhibition , we determined ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , expression by Western blot analysis in troglitazone treated HLF cells . Negative_regulation CDK4 IFI27 15048878 1225244 We conclude that substrate dependent acquisition of proliferative phenotypes following repeated cycles of AAM injury correlates with modulation of the [cyclin dependent kinase] *inhibitors* , and p21 . Negative_regulation CDK4 IFI27 15138205 1246186 Gastric cells chronically exposed to H pylori in vitro develop resistance to apoptosis associated with low levels of , a [cyclin dependent kinase] *inhibitor* and haplo insufficient tumour suppressor gene that is downregulated in gastric cancer . Negative_regulation CDK4 IFI27 15224009 1264882 A high level of , an *inhibitor* of [cyclin dependent kinase] that correlates with the degree of in vitro apoptosis , is found in B-CLL cells . Negative_regulation CDK4 IFI27 15263796 1275070 The prognostic significance of cyclins D1 , E and [cyclin dependent kinase] *inhibitors* p21 ( Waf1/Cip1 ) , ( Kip1 ) in determining the risk of recurrence and progression with both univariate ( log rank test ) and multivariate ( Cox regression ) methods of analysis showed no statistically significance differences . Negative_regulation CDK4 IFI27 15378017 1324009 In the present study , we investigated the consequences of the combined loss of either of two [cyclin dependent kinase] *inhibitors* , p21 and , in cooperation with deletion of the INK4a/ARF locus . Negative_regulation CDK4 IFI27 15474987 1354677 Under the same conditions , adding MG or HK to VD3 or ATRA treatment further enlarged the G0/G1 cell population and increased the expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK4 IFI27 15491288 1321371 In addition , in myeloma cells subjected to growth-factor starvation , the upregulation of PGP9.5 was observed in association with that of ( Kip1 ) , a [cyclin-dependent-kinase] *inhibitor* , although the upregulation caused by irradiation was milder . Negative_regulation CDK4 IFI27 15799773 1390559 Several genes , including insulin-like growth factor 1 (IGF-1) and [cyclin dependent kinase] *inhibitor* ( ( Kip1 ) ) were induced by both injury types and these may have potential clinical application as markers of tissue damage . Negative_regulation CDK4 IFI27 15930262 1414422 Here , we found that VDUP1-/- fibroblast cells proliferated more rapidly compared with wild-type cells with reduced expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK4 IFI27 16020508 1465812 Tregs were blocked from cell cycle progression due to decrease of cyclin E and cyclin A and increase of ( p27kip [cyclin dependent kinase] *inhibitor* ) . Negative_regulation CDK4 IFI27 16039115 1473602 Levels of expression of cyclins , cyclin dependent kinases and [cyclin dependent kinase] *inhibitors* , p21 and , were analysed by western blotting . Negative_regulation CDK4 IFI27 16328436 1503619 [Cyclin dependent kinase] *inhibitors* CIP1 ( p21 ) and KIP1 ( ) in ovarian cancer . Negative_regulation CDK4 IFI27 16427178 1567168 In this study , under treatment with various concentrations of PA in MDA-MB 231 cell line , we checked mRNA levels for cyclin A and cyclin B1 and the protein levels of cyclin A and cyclin B1 , Cdc2 ( cyclin dependent kinases ) , p21 ( waf1/cip1 ) and ( Kip1 ) ( [cyclin dependent kinase] *inhibitors* ) , Cdc25C , Chk2 and Wee1 kinase ( cyclin dependent kinase relative factors ) in cell cycle G2/M phase . Negative_regulation CDK4 IFI27 16436005 1495303 ( kip1 ) , a universal [cyclin dependent kinase] *inhibitor* , is a useful marker for predicting clinical aggressiveness with various human tumors . Negative_regulation CDK4 IFI27 16564150 1555716 In contrast , protein levels of , a [cyclin dependent kinase] *inhibitor* , are increased after induction of ER-stress using tunicamycin . Negative_regulation CDK4 IFI27 17360552 1712751 As proof of principle , we studied the consequence of sporadic loss of , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK4 IFI27 17918155 1843870 Furthermore , we find that the growth inhibitory dose of R1881 leads to increases in the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21 and as well as to G1 arrest . Negative_regulation CDK4 IFI27 17979972 1874280 Terrein was found to downregulate cyclin B1 and Cdc2 without Cdc2 phosphorylation , but upregulated ( KIP1 ) ( p27 ) , a known *inhibitor* of [cyclin dependent kinase] . Negative_regulation CDK4 IFI27 18583941 1953301 Roles of [cyclin dependent kinase] *inhibitors* , p21/Cip1 ( p21 ) and p27/Kip1 ( ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation CDK4 IFI27 19026637 2022724 Activation of ERK1/2 was not affected by MacCM , and neither was the expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK4 IFI27 19147535 2026276 Two [cyclin dependent kinase] *inhibitors* , p18 ( Ink4c ) and ( Kip1 ) , are required for proper cerebellar development . Negative_regulation CDK4 IFI27 19276255 2046189 In retrospective studies , loss of ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has been associated with poor prognosis following colorectal cancer treatment . Negative_regulation CDK4 IFI27 19321452 2073934 Although HSC70 directly bound to ( Kip1 ) ( a [cyclin dependent kinase] *inhibitor* ) , histatin 3 increased the binding between those proteins but not with a peptide capable of binding to HSC70 . Negative_regulation CDK4 IFI27 19538337 2103566 In this study , we examined the role of melatonin on synoviocyte proliferation in primary cultured human fibroblast-like synoviocytes ( FLSs ) by analyzing protein expression of P21 ( CIP1 ) ( P21 ) and ( KIP1 ) ( P27 ) , the [cyclin dependent kinase] *inhibitors* that are important in cell cycle control , and the phosphorylation of mitogen activated protein kinases ( MAPKs ) . Negative_regulation CDK4 IFI27 19598246 2149812 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is also known to demarcate the prosensory region in the cochlear primordium , which consists of the sensory progenitors that have completed their terminal mitoses . Negative_regulation CDK4 IFI27 19720293 2133705 Trastuzumab , a humanized antibody directed against the Her2 receptor , induces the expression of ( kip1 ) , an intranuclear [cyclin dependent kinase] *inhibitor* in some breast cancer cells . Negative_regulation CDK4 IFI27 21443540 2438443 Furthermore , NS expression was associated with cellular proliferation in OSCC cell lines using siRNA , which upregulated , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK4 IFI27 21980125 2502930 Further , deletion of AMPKa2 but not AMPKa1 reduced the level of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , and increased the level of S-phase kinase associated protein 2 ( Skp2 ) , a known E3 ubiquitin ligase for p27 ( Kip1 ) , through activation of p52 nuclear factor kappa B ( NF-?B ) -2 . Negative_regulation CDK4 IFI27 22154697 2563119 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) of the CIP/KIP family , p21 , and p57 , mediate cell cycle inhibition . Negative_regulation CDK4 IFI27 22460505 2637124 Cell cycle analysis indicated thioridazine induced the down-regulation of cyclin D1 , cyclin A and CDK4 , and the induction of p21 and , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK4 IFI27 22851678 2677188 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , ( Kip1 ) , and cyclin D1 . Negative_regulation CDK4 IFI27 23255047 2827355 Skp2 mediated degradation of , a [cyclin dependent kinase] *inhibitor* , is involved in cell cycle regulation . Negative_regulation CDK4 IFI27 23721824 2819704 miR-370 induced proliferation was correlated with the downregulation of [cyclin dependent kinase] *inhibitors* , ( Kip1 ) and p21 ( Cip1 ) , and the upregulation of the cell cycle regulator cyclin D1 . Negative_regulation CDK4 IFI27 23888319 2901995 Our results found that curcumin inhibited cell proliferation , which was associated with upregulation of the [cyclin dependent kinase] *inhibitors* , and p21 , and downregulation of cyclin D1 . Negative_regulation CDK4 IFI27 23944957 2887968 We determined whether proliferation and IL-6 release are abnormal in ASM cells ( ASMCs ) from patients with severe asthma , and whether these features could be mediated by microRNA-221 and microRNA-222 , through modulation of the [cyclin dependent kinase] *inhibitors* , p21 ( WAF1 ) and ( kip1 ) . Negative_regulation CDK4 IFI27 24067984 2867168 Western blot analysis of key cell cycle regulators revealed that K-Rta mediated cell cycle arrest was associated with a decrease in cyclin A and phosphorylated Rb ( pS807/pS811 ) protein levels , both markers of S phase progression , and an increase in protein levels for , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK4 IFI27 24708177 2938870 Recently , STMN1 was reported to interact with , an *inhibitor* of [cyclin dependent kinase] complexes . Negative_regulation CDK4 IFI27 8654372 366870 Expression of Zta results in induction of the tumor suppressor protein , p53 , and the [cyclin dependent kinase] *inhibitors* , p21 and , as well as accumulation of hypophosphorylated pRb . Negative_regulation CDK4 IFI27 8845296 337823 We have examined the level of cyclin E , a G1 cyclin , and , a [cyclin dependent kinase] *inhibitor* , in BALB/c 3T3 cells . Negative_regulation CDK4 IFI27 9325318 456847 In contrast , the same or a larger increase in levels did not *inhibit* [Cdk4] or its homologue Cdk6 , despite extensive binding to these kinases . Negative_regulation CDK4 IFI27 9616167 509581 The identification of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* that contributes to cell cycle arrest and represents a link between extracellular signals and cell cycle , prompted us to study p27 protein in the lymphocytes from 88 patients with B-CLL and 32 patients with other chronic B-lymphoproliferative disorders . Negative_regulation CDK4 IFI27 9746784 532995 The ( kip-1 ) , a [cyclin dependent kinase] *inhibitor* which is important in blocking the cell cycle , was induced more quickly and potently by Ro 25-9716 ( 10 ( -7 ) mol/L , 0 to 5 days ) than by 1,25D3 , suggesting a possible mechanism by which these analogs inhibit proliferation of leukemic growth . Negative_regulation CDK4 IFI27 9891946 558554 Hence , we have determined the cell cycle profile , expressions and activities of the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21CIP1 and , during rat ventricular myocyte development . Negative_regulation CDK4 ITGA9 22138449 2536213 Furthermore , effects of p21 , a [cyclin dependent kinase] *inhibitor* , and integrin a9 ( ) were examined . Negative_regulation CDK4 ITGAL 9865919 556411 These include myc proto-oncogene , 40S ribosomal protein S19 , heat shock proteins , leukosialin S ( CD43 ) , integrin alphaL ( ) , calgranulin (A) , and [CDK4] *inhibitor* ( p16ink4 ) . Negative_regulation CDK4 MAP2K6 10597223 573399 p21Cip1/Waf1 [cyclin dependent kinase] inhibitor ( p21 ) is *inducible* by Raf and ( MAPKK ) , but the level of regulation is unknown . Negative_regulation CDK4 MAP2K6 21871886 2491226 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK4 RARB 21868513 2473722 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Negative_regulation CDK4 TNF 21811927 2462725 Furthermore , treatment with OD 78 decreased *induced* levels of cyclin E , cyclin D1 , CDK2 , proliferating cell nuclear antigen , and phosphorylated retinoblastoma protein , but not the [CDK4] expression level . Negative_regulation CDK5 CCND1 22851678 2677189 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , p27 ( Kip1 ) , and . Negative_regulation CDK5 CCND1 24399246 2906972 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) ( p21Cip1 , p27Kip1 , p15INK4B ) , and cyclin E were shown to be differentially expressed in latexin overexpressed cells and latexin silenced cells . Negative_regulation CDK5 CDKN1C 11347369 814330 The expression of , a [cyclin dependent kinase] *inhibitor* , is a strong indicator that the cells are exiting the cell cycle and are beginning to differentiate . Negative_regulation CDK5 CDKN1C 11529881 853615 We examine the cell proliferation activity and expression of [cyclin dependent kinase] *inhibitors* of the Cip/Kip family , p21Cip1 , p27Kip1 and , in foetal hamster lungs to determine the expression patterns of the cyclin dependent kinase inhibitors and to clarify the relationship between expression of the cyclin dependent kinase inhibitors and lung development . Negative_regulation CDK5 CDKN1C 15224347 1264951 The expression of ( Kip2 ) , a [cyclin dependent kinase] *inhibitor* that was also in the imprinted region , exhibited some variable increased expression predominantly in hepatic neoplasms from livers of female TG+ rats . Negative_regulation CDK5 CDKN1C 15537824 1367513 In contrast , EGCG accelerates terminal differentiation in normal human epidermal keratinocytes ( NHEK ) mediated partially by up-regulation of , a [cyclin dependent kinase] *inhibitor* that confers growth arrest and differentiation . Negative_regulation CDK5 CDKN1C 16731797 1566006 Differential expression of [cyclin dependent kinase] *inhibitors* , p27Kip1 and , by corticotropin in rat adrenal cortex . Negative_regulation CDK5 CDKN1C 16731797 1566044 An important role for the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p27Kip1 and , in the proliferation and differentiation of adrenal cells has been suggested by their knockout mice , which display adrenal hyperplasia . Negative_regulation CDK5 CDKN1C 18822693 1970540 The aim of this study was to establish the importance of , a unique [cyclin dependent kinase] *inhibitor* , in the oncogenesis of bladder carcinoma . Negative_regulation CDK5 CDKN1C 20503313 2263853 A small number of individuals with BWS ( 5-10 % ) have mutations in , a [cyclin dependent kinase] *inhibitor* of G1 cyclin complexes that functions as a negative regulator of cellular growth and proliferation . Negative_regulation CDK5 CDKN1C 21322636 2443303 p21 was found to be a key regulator of this process , because down-regulation of the [cyclin dependent kinase] *inhibitors* p27 ( CDKN1B/KIP1 ) or p57 ( ) or the tumor suppressor p53 ( TP53/LFS1 ) failed to induce proliferation and subsequent dedifferentiation . Negative_regulation CDK5 CDKN1C 22996691 2679053 Expression of , a BMP10 regulated [cyclin dependent kinase] *inhibitor* , was induced in Myocd-/- hearts , while BMP10 activated cardiogenic transcription factors , including NKX2.5 and MEF2c , were repressed . Negative_regulation CDK5 CDKN1C 7550351 323235 Genomic imprinting of , a [cyclin dependent kinase] *inhibitor* , in mouse . Negative_regulation CDK5 CDKN1C 7729683 302212 Cloning of , a [cyclin dependent kinase] *inhibitor* with unique domain structure and tissue distribution . Negative_regulation CDK5 CDKN1C 8923002 397211 The gene for insulin-like growth factor II (IGF2) is normally expressed from the paternal allele , while H19 and , a [cyclin dependent kinase] *inhibitor* , are expressed from the maternal allele . Negative_regulation CDK5 CDKN1C 9311734 455012 these include the gene for insulin-like growth factor II (IGF2) and H19 , which show abnormal imprint-specific expression and/or methylation in 20 % of BWS patients , and , a [cyclin dependent kinase] *inhibitor* , which we found showed biallelic expression in one of nine BWS patients studied . Negative_regulation CDK5 EPHB2 17108320 1686010 To further explore the nature of this inhibition , we studied the kinetics of NGF activation of extracellular signal regulated kinase ( ) 1/2 in cortical neurons with or without roscovitine , an *inhibitor* of [Cdk5] . Negative_regulation CDK5 EPHB2 20855497 2325807 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Negative_regulation CDK5 EPHB2 21871886 2491230 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK5 IFI27 10198213 605038 73-kDa heat shock cognate protein interacts directly with , a [cyclin dependent kinase] *inhibitor* , during G1/S transition . Negative_regulation CDK5 IFI27 10198213 605076 In the present study , we demonstrated that 73hsc ( heat shock cognate protein ) , which belongs to the HSP70 family of molecular chaperones , interacts with , an *inhibitor* of [cyclin dependent kinase] , during G1/S transition . Negative_regulation CDK5 IFI27 10510349 651107 The treatment of macrophages with adenosine induces the expression of , a G1 [cyclin dependent kinase] *inhibitor* , in a protein kinase A-dependent way . Negative_regulation CDK5 IFI27 10859299 715248 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in many types of carcinomas . Negative_regulation CDK5 IFI27 10861499 705306 ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has an important role in the progression of cells from G ( 1 ) into S phase of the cell cycle . Negative_regulation CDK5 IFI27 10903892 713403 Minimal requirements for the nuclear localization of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK5 IFI27 11136238 786710 Previous work has shown that cyclin A can be cleaved at Arg-70/Arg-71 by a proteolytic activity present in an in vitro coupled transcription/translation system by using rabbit reticulocyte lysate programmed by plasmid DNA encoding ( KIP1 ) , a [cyclin dependent kinase] *inhibitor* , but not by plasmid DNAs encoding other cyclin dependent kinases inhibitors . Negative_regulation CDK5 IFI27 11164713 782661 [Cyclin dependent kinase] *inhibitors* , p21 ( waf1/cip1 ) and ( kip1 ) , are expressed site- and hair cycle-dependently in rat hair follicles . Negative_regulation CDK5 IFI27 11237531 790107 A major function of , also known as Kip1 , is to bind and *inhibit* [cyclin/cyclin dependent kinase] complexes , thereby blocking cell cycle progression . Negative_regulation CDK5 IFI27 11251953 793940 Low expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is a marker of poor prognosis in synovial sarcoma . Negative_regulation CDK5 IFI27 11251953 793959 Low expression of ( kip1 ) , a dominant [cyclin dependent kinase] *inhibitor* involved in G1-S transition of the cell cycle , recently has been reported to be associated with aggressive tumor growth . Negative_regulation CDK5 IFI27 11301477 803361 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in breast cancer . Negative_regulation CDK5 IFI27 11400230 824392 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , negatively regulates the G1 phase progression of the cell cycle by binding to the cyclin E/cyclin dependent kinase 2 complex . Negative_regulation CDK5 IFI27 11557117 861245 , a [cyclin dependent kinase] *inhibitor* , regulates the progression from G1 into the S phase by binding and inhibiting cyclin/cdks . Negative_regulation CDK5 IFI27 11744034 897890 Levels of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p16 and , were initially high in quiescent isolated cells and tissue ; Negative_regulation CDK5 IFI27 11745414 888960 Herein , expression of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p21 , and p57 and their associated kinase activities were examined in 61 cases of soft tissue smooth muscle tumors . Negative_regulation CDK5 IFI27 11850846 913184 LY294002 also causes an increase in , a [cyclin dependent kinase] *inhibitor* and results in the dephosphorylation of members of the pocket protein family . Negative_regulation CDK5 IFI27 11856766 914397 The differentiation was accompanied by a growth arrest and the upregulation of [cyclin dependent kinase] *inhibitors* , and p57 , as well as cyclin D(1) , whereas cyclin A was downregulated . Negative_regulation CDK5 IFI27 12097295 961270 Reduced expression level of , a [cyclin dependent kinase] *inhibitor* , is associated with high aggressiveness and poor prognosis of various malignant tumors , including gastric carcinoma . Negative_regulation CDK5 IFI27 12465754 1022255 Calcitriol induces a significant G0/G1 arrest and modulates p21 ( Waf/Cip1 ) and ( Kip1 ) , the [cyclin dependent kinase] *inhibitors* . Negative_regulation CDK5 IFI27 12663518 1074539 IP6 strongly increased the expression of CDKIs ( [cyclin dependent kinase] *inhibitors* ) , Cip1/p21 and , without any noticeable changes in G1 CDKs and cyclins , except a slight increase in cyclin D2 . Negative_regulation CDK5 IFI27 12771291 1094744 Parathyroid cell growth in patients with advanced secondary hyperparathyroidism : vitamin D receptor and [cyclin dependent kinase] *inhibitors* , p21 and . Negative_regulation CDK5 IFI27 12943995 1135793 We also observed a simultaneous increase in the expression of [cyclin-dependent-kinase] *inhibitors* , p21 , , p15 and p16 , associated with a loss in expression of Cyclin-A2 and Cyclin-E . Negative_regulation CDK5 IFI27 14618613 1188020 To examine the mechanism of the troglitazone induced growth inhibition , we determined ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , expression by Western blot analysis in troglitazone treated HLF cells . Negative_regulation CDK5 IFI27 15048878 1225246 We conclude that substrate dependent acquisition of proliferative phenotypes following repeated cycles of AAM injury correlates with modulation of the [cyclin dependent kinase] *inhibitors* , and p21 . Negative_regulation CDK5 IFI27 15138205 1246187 Gastric cells chronically exposed to H pylori in vitro develop resistance to apoptosis associated with low levels of , a [cyclin dependent kinase] *inhibitor* and haplo insufficient tumour suppressor gene that is downregulated in gastric cancer . Negative_regulation CDK5 IFI27 15224009 1264884 A high level of , an *inhibitor* of [cyclin dependent kinase] that correlates with the degree of in vitro apoptosis , is found in B-CLL cells . Negative_regulation CDK5 IFI27 15263796 1275071 The prognostic significance of cyclins D1 , E and [cyclin dependent kinase] *inhibitors* p21 ( Waf1/Cip1 ) , ( Kip1 ) in determining the risk of recurrence and progression with both univariate ( log rank test ) and multivariate ( Cox regression ) methods of analysis showed no statistically significance differences . Negative_regulation CDK5 IFI27 15378017 1324011 In the present study , we investigated the consequences of the combined loss of either of two [cyclin dependent kinase] *inhibitors* , p21 and , in cooperation with deletion of the INK4a/ARF locus . Negative_regulation CDK5 IFI27 15474987 1354678 Under the same conditions , adding MG or HK to VD3 or ATRA treatment further enlarged the G0/G1 cell population and increased the expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK5 IFI27 15491288 1321372 In addition , in myeloma cells subjected to growth-factor starvation , the upregulation of PGP9.5 was observed in association with that of ( Kip1 ) , a [cyclin-dependent-kinase] *inhibitor* , although the upregulation caused by irradiation was milder . Negative_regulation CDK5 IFI27 15799773 1390560 Several genes , including insulin-like growth factor 1 (IGF-1) and [cyclin dependent kinase] *inhibitor* ( ( Kip1 ) ) were induced by both injury types and these may have potential clinical application as markers of tissue damage . Negative_regulation CDK5 IFI27 15930262 1414423 Here , we found that VDUP1-/- fibroblast cells proliferated more rapidly compared with wild-type cells with reduced expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK5 IFI27 16020508 1465814 Tregs were blocked from cell cycle progression due to decrease of cyclin E and cyclin A and increase of ( p27kip [cyclin dependent kinase] *inhibitor* ) . Negative_regulation CDK5 IFI27 16039115 1473604 Levels of expression of cyclins , cyclin dependent kinases and [cyclin dependent kinase] *inhibitors* , p21 and , were analysed by western blotting . Negative_regulation CDK5 IFI27 16328436 1503620 [Cyclin dependent kinase] *inhibitors* CIP1 ( p21 ) and KIP1 ( ) in ovarian cancer . Negative_regulation CDK5 IFI27 16427178 1567170 In this study , under treatment with various concentrations of PA in MDA-MB 231 cell line , we checked mRNA levels for cyclin A and cyclin B1 and the protein levels of cyclin A and cyclin B1 , Cdc2 ( cyclin dependent kinases ) , p21 ( waf1/cip1 ) and ( Kip1 ) ( [cyclin dependent kinase] *inhibitors* ) , Cdc25C , Chk2 and Wee1 kinase ( cyclin dependent kinase relative factors ) in cell cycle G2/M phase . Negative_regulation CDK5 IFI27 16436005 1495304 ( kip1 ) , a universal [cyclin dependent kinase] *inhibitor* , is a useful marker for predicting clinical aggressiveness with various human tumors . Negative_regulation CDK5 IFI27 16564150 1555717 In contrast , protein levels of , a [cyclin dependent kinase] *inhibitor* , are increased after induction of ER-stress using tunicamycin . Negative_regulation CDK5 IFI27 17360552 1712753 As proof of principle , we studied the consequence of sporadic loss of , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK5 IFI27 17918155 1843872 Furthermore , we find that the growth inhibitory dose of R1881 leads to increases in the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21 and as well as to G1 arrest . Negative_regulation CDK5 IFI27 17979972 1874281 Terrein was found to downregulate cyclin B1 and Cdc2 without Cdc2 phosphorylation , but upregulated ( KIP1 ) ( p27 ) , a known *inhibitor* of [cyclin dependent kinase] . Negative_regulation CDK5 IFI27 18583941 1953305 Roles of [cyclin dependent kinase] *inhibitors* , p21/Cip1 ( p21 ) and p27/Kip1 ( ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation CDK5 IFI27 19026637 2022725 Activation of ERK1/2 was not affected by MacCM , and neither was the expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK5 IFI27 19147535 2026278 Two [cyclin dependent kinase] *inhibitors* , p18 ( Ink4c ) and ( Kip1 ) , are required for proper cerebellar development . Negative_regulation CDK5 IFI27 19276255 2046190 In retrospective studies , loss of ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has been associated with poor prognosis following colorectal cancer treatment . Negative_regulation CDK5 IFI27 19321452 2073935 Although HSC70 directly bound to ( Kip1 ) ( a [cyclin dependent kinase] *inhibitor* ) , histatin 3 increased the binding between those proteins but not with a peptide capable of binding to HSC70 . Negative_regulation CDK5 IFI27 19538337 2103568 In this study , we examined the role of melatonin on synoviocyte proliferation in primary cultured human fibroblast-like synoviocytes ( FLSs ) by analyzing protein expression of P21 ( CIP1 ) ( P21 ) and ( KIP1 ) ( P27 ) , the [cyclin dependent kinase] *inhibitors* that are important in cell cycle control , and the phosphorylation of mitogen activated protein kinases ( MAPKs ) . Negative_regulation CDK5 IFI27 19598246 2149813 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is also known to demarcate the prosensory region in the cochlear primordium , which consists of the sensory progenitors that have completed their terminal mitoses . Negative_regulation CDK5 IFI27 19720293 2133706 Trastuzumab , a humanized antibody directed against the Her2 receptor , induces the expression of ( kip1 ) , an intranuclear [cyclin dependent kinase] *inhibitor* in some breast cancer cells . Negative_regulation CDK5 IFI27 21443540 2438444 Furthermore , NS expression was associated with cellular proliferation in OSCC cell lines using siRNA , which upregulated , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK5 IFI27 21980125 2502931 Further , deletion of AMPKa2 but not AMPKa1 reduced the level of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , and increased the level of S-phase kinase associated protein 2 ( Skp2 ) , a known E3 ubiquitin ligase for p27 ( Kip1 ) , through activation of p52 nuclear factor kappa B ( NF-?B ) -2 . Negative_regulation CDK5 IFI27 22154697 2563120 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) of the CIP/KIP family , p21 , and p57 , mediate cell cycle inhibition . Negative_regulation CDK5 IFI27 22460505 2637126 Cell cycle analysis indicated thioridazine induced the down-regulation of cyclin D1 , cyclin A and CDK4 , and the induction of p21 and , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK5 IFI27 22851678 2677191 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , ( Kip1 ) , and cyclin D1 . Negative_regulation CDK5 IFI27 23255047 2827356 Skp2 mediated degradation of , a [cyclin dependent kinase] *inhibitor* , is involved in cell cycle regulation . Negative_regulation CDK5 IFI27 23721824 2819706 miR-370 induced proliferation was correlated with the downregulation of [cyclin dependent kinase] *inhibitors* , ( Kip1 ) and p21 ( Cip1 ) , and the upregulation of the cell cycle regulator cyclin D1 . Negative_regulation CDK5 IFI27 23888319 2901997 Our results found that curcumin inhibited cell proliferation , which was associated with upregulation of the [cyclin dependent kinase] *inhibitors* , and p21 , and downregulation of cyclin D1 . Negative_regulation CDK5 IFI27 23944957 2887970 We determined whether proliferation and IL-6 release are abnormal in ASM cells ( ASMCs ) from patients with severe asthma , and whether these features could be mediated by microRNA-221 and microRNA-222 , through modulation of the [cyclin dependent kinase] *inhibitors* , p21 ( WAF1 ) and ( kip1 ) . Negative_regulation CDK5 IFI27 24067984 2867169 Western blot analysis of key cell cycle regulators revealed that K-Rta mediated cell cycle arrest was associated with a decrease in cyclin A and phosphorylated Rb ( pS807/pS811 ) protein levels , both markers of S phase progression , and an increase in protein levels for , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK5 IFI27 24708177 2938871 Recently , STMN1 was reported to interact with , an *inhibitor* of [cyclin dependent kinase] complexes . Negative_regulation CDK5 IFI27 8654372 366872 Expression of Zta results in induction of the tumor suppressor protein , p53 , and the [cyclin dependent kinase] *inhibitors* , p21 and , as well as accumulation of hypophosphorylated pRb . Negative_regulation CDK5 IFI27 8845296 337826 We have examined the level of cyclin E , a G1 cyclin , and , a [cyclin dependent kinase] *inhibitor* , in BALB/c 3T3 cells . Negative_regulation CDK5 IFI27 9616167 509582 The identification of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* that contributes to cell cycle arrest and represents a link between extracellular signals and cell cycle , prompted us to study p27 protein in the lymphocytes from 88 patients with B-CLL and 32 patients with other chronic B-lymphoproliferative disorders . Negative_regulation CDK5 IFI27 9746784 532996 The ( kip-1 ) , a [cyclin dependent kinase] *inhibitor* which is important in blocking the cell cycle , was induced more quickly and potently by Ro 25-9716 ( 10 ( -7 ) mol/L , 0 to 5 days ) than by 1,25D3 , suggesting a possible mechanism by which these analogs inhibit proliferation of leukemic growth . Negative_regulation CDK5 IFI27 9891946 558558 Hence , we have determined the cell cycle profile , expressions and activities of the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21CIP1 and , during rat ventricular myocyte development . Negative_regulation CDK5 ITGA9 22138449 2536214 Furthermore , effects of p21 , a [cyclin dependent kinase] *inhibitor* , and integrin a9 ( ) were examined . Negative_regulation CDK5 MAP2K6 10597223 573407 p21Cip1/Waf1 [cyclin dependent kinase] inhibitor ( p21 ) is *inducible* by Raf and ( MAPKK ) , but the level of regulation is unknown . Negative_regulation CDK5 MAP2K6 21871886 2491236 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK5 RARB 21868513 2473723 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Negative_regulation CDK6 CCND1 22851678 2677192 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , p27 ( Kip1 ) , and . Negative_regulation CDK6 CCND1 24399246 2906973 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) ( p21Cip1 , p27Kip1 , p15INK4B ) , and cyclin E were shown to be differentially expressed in latexin overexpressed cells and latexin silenced cells . Negative_regulation CDK6 CDKN1C 11347369 814331 The expression of , a [cyclin dependent kinase] *inhibitor* , is a strong indicator that the cells are exiting the cell cycle and are beginning to differentiate . Negative_regulation CDK6 CDKN1C 11529881 853618 We examine the cell proliferation activity and expression of [cyclin dependent kinase] *inhibitors* of the Cip/Kip family , p21Cip1 , p27Kip1 and , in foetal hamster lungs to determine the expression patterns of the cyclin dependent kinase inhibitors and to clarify the relationship between expression of the cyclin dependent kinase inhibitors and lung development . Negative_regulation CDK6 CDKN1C 15224347 1264952 The expression of ( Kip2 ) , a [cyclin dependent kinase] *inhibitor* that was also in the imprinted region , exhibited some variable increased expression predominantly in hepatic neoplasms from livers of female TG+ rats . Negative_regulation CDK6 CDKN1C 15537824 1367514 In contrast , EGCG accelerates terminal differentiation in normal human epidermal keratinocytes ( NHEK ) mediated partially by up-regulation of , a [cyclin dependent kinase] *inhibitor* that confers growth arrest and differentiation . Negative_regulation CDK6 CDKN1C 16731797 1566008 Differential expression of [cyclin dependent kinase] *inhibitors* , p27Kip1 and , by corticotropin in rat adrenal cortex . Negative_regulation CDK6 CDKN1C 16731797 1566046 An important role for the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p27Kip1 and , in the proliferation and differentiation of adrenal cells has been suggested by their knockout mice , which display adrenal hyperplasia . Negative_regulation CDK6 CDKN1C 18822693 1970541 The aim of this study was to establish the importance of , a unique [cyclin dependent kinase] *inhibitor* , in the oncogenesis of bladder carcinoma . Negative_regulation CDK6 CDKN1C 20503313 2263854 A small number of individuals with BWS ( 5-10 % ) have mutations in , a [cyclin dependent kinase] *inhibitor* of G1 cyclin complexes that functions as a negative regulator of cellular growth and proliferation . Negative_regulation CDK6 CDKN1C 21322636 2443305 p21 was found to be a key regulator of this process , because down-regulation of the [cyclin dependent kinase] *inhibitors* p27 ( CDKN1B/KIP1 ) or p57 ( ) or the tumor suppressor p53 ( TP53/LFS1 ) failed to induce proliferation and subsequent dedifferentiation . Negative_regulation CDK6 CDKN1C 22996691 2679054 Expression of , a BMP10 regulated [cyclin dependent kinase] *inhibitor* , was induced in Myocd-/- hearts , while BMP10 activated cardiogenic transcription factors , including NKX2.5 and MEF2c , were repressed . Negative_regulation CDK6 CDKN1C 7550351 323236 Genomic imprinting of , a [cyclin dependent kinase] *inhibitor* , in mouse . Negative_regulation CDK6 CDKN1C 7729683 302213 Cloning of , a [cyclin dependent kinase] *inhibitor* with unique domain structure and tissue distribution . Negative_regulation CDK6 CDKN1C 8923002 397213 The gene for insulin-like growth factor II (IGF2) is normally expressed from the paternal allele , while H19 and , a [cyclin dependent kinase] *inhibitor* , are expressed from the maternal allele . Negative_regulation CDK6 CDKN1C 9311734 455013 these include the gene for insulin-like growth factor II (IGF2) and H19 , which show abnormal imprint-specific expression and/or methylation in 20 % of BWS patients , and , a [cyclin dependent kinase] *inhibitor* , which we found showed biallelic expression in one of nine BWS patients studied . Negative_regulation CDK6 EPHB2 20855497 2325810 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Negative_regulation CDK6 EPHB2 21871886 2491240 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK6 IFI27 10198213 605040 73-kDa heat shock cognate protein interacts directly with , a [cyclin dependent kinase] *inhibitor* , during G1/S transition . Negative_regulation CDK6 IFI27 10198213 605078 In the present study , we demonstrated that 73hsc ( heat shock cognate protein ) , which belongs to the HSP70 family of molecular chaperones , interacts with , an *inhibitor* of [cyclin dependent kinase] , during G1/S transition . Negative_regulation CDK6 IFI27 10510349 651109 The treatment of macrophages with adenosine induces the expression of , a G1 [cyclin dependent kinase] *inhibitor* , in a protein kinase A-dependent way . Negative_regulation CDK6 IFI27 10859299 715249 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in many types of carcinomas . Negative_regulation CDK6 IFI27 10861499 705307 ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has an important role in the progression of cells from G ( 1 ) into S phase of the cell cycle . Negative_regulation CDK6 IFI27 10903892 713404 Minimal requirements for the nuclear localization of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK6 IFI27 11136238 786711 Previous work has shown that cyclin A can be cleaved at Arg-70/Arg-71 by a proteolytic activity present in an in vitro coupled transcription/translation system by using rabbit reticulocyte lysate programmed by plasmid DNA encoding ( KIP1 ) , a [cyclin dependent kinase] *inhibitor* , but not by plasmid DNAs encoding other cyclin dependent kinases inhibitors . Negative_regulation CDK6 IFI27 11164713 782663 [Cyclin dependent kinase] *inhibitors* , p21 ( waf1/cip1 ) and ( kip1 ) , are expressed site- and hair cycle-dependently in rat hair follicles . Negative_regulation CDK6 IFI27 11237531 790108 A major function of , also known as Kip1 , is to bind and *inhibit* [cyclin/cyclin dependent kinase] complexes , thereby blocking cell cycle progression . Negative_regulation CDK6 IFI27 11251953 793941 Low expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is a marker of poor prognosis in synovial sarcoma . Negative_regulation CDK6 IFI27 11251953 793960 Low expression of ( kip1 ) , a dominant [cyclin dependent kinase] *inhibitor* involved in G1-S transition of the cell cycle , recently has been reported to be associated with aggressive tumor growth . Negative_regulation CDK6 IFI27 11301477 803362 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in breast cancer . Negative_regulation CDK6 IFI27 11400230 824393 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , negatively regulates the G1 phase progression of the cell cycle by binding to the cyclin E/cyclin dependent kinase 2 complex . Negative_regulation CDK6 IFI27 11557117 861246 , a [cyclin dependent kinase] *inhibitor* , regulates the progression from G1 into the S phase by binding and inhibiting cyclin/cdks . Negative_regulation CDK6 IFI27 11744034 897891 Levels of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p16 and , were initially high in quiescent isolated cells and tissue ; Negative_regulation CDK6 IFI27 11745414 888961 Herein , expression of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p21 , and p57 and their associated kinase activities were examined in 61 cases of soft tissue smooth muscle tumors . Negative_regulation CDK6 IFI27 11850846 913186 LY294002 also causes an increase in , a [cyclin dependent kinase] *inhibitor* and results in the dephosphorylation of members of the pocket protein family . Negative_regulation CDK6 IFI27 11856766 914398 The differentiation was accompanied by a growth arrest and the upregulation of [cyclin dependent kinase] *inhibitors* , and p57 , as well as cyclin D(1) , whereas cyclin A was downregulated . Negative_regulation CDK6 IFI27 12097295 961271 Reduced expression level of , a [cyclin dependent kinase] *inhibitor* , is associated with high aggressiveness and poor prognosis of various malignant tumors , including gastric carcinoma . Negative_regulation CDK6 IFI27 12465754 1022257 Calcitriol induces a significant G0/G1 arrest and modulates p21 ( Waf/Cip1 ) and ( Kip1 ) , the [cyclin dependent kinase] *inhibitors* . Negative_regulation CDK6 IFI27 12663518 1074543 IP6 strongly increased the expression of CDKIs ( [cyclin dependent kinase] *inhibitors* ) , Cip1/p21 and , without any noticeable changes in G1 CDKs and cyclins , except a slight increase in cyclin D2 . Negative_regulation CDK6 IFI27 12771291 1094746 Parathyroid cell growth in patients with advanced secondary hyperparathyroidism : vitamin D receptor and [cyclin dependent kinase] *inhibitors* , p21 and . Negative_regulation CDK6 IFI27 12943995 1135795 We also observed a simultaneous increase in the expression of [cyclin-dependent-kinase] *inhibitors* , p21 , , p15 and p16 , associated with a loss in expression of Cyclin-A2 and Cyclin-E . Negative_regulation CDK6 IFI27 14618613 1188021 To examine the mechanism of the troglitazone induced growth inhibition , we determined ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , expression by Western blot analysis in troglitazone treated HLF cells . Negative_regulation CDK6 IFI27 15048878 1225248 We conclude that substrate dependent acquisition of proliferative phenotypes following repeated cycles of AAM injury correlates with modulation of the [cyclin dependent kinase] *inhibitors* , and p21 . Negative_regulation CDK6 IFI27 15138205 1246188 Gastric cells chronically exposed to H pylori in vitro develop resistance to apoptosis associated with low levels of , a [cyclin dependent kinase] *inhibitor* and haplo insufficient tumour suppressor gene that is downregulated in gastric cancer . Negative_regulation CDK6 IFI27 15224009 1264886 A high level of , an *inhibitor* of [cyclin dependent kinase] that correlates with the degree of in vitro apoptosis , is found in B-CLL cells . Negative_regulation CDK6 IFI27 15263796 1275072 The prognostic significance of cyclins D1 , E and [cyclin dependent kinase] *inhibitors* p21 ( Waf1/Cip1 ) , ( Kip1 ) in determining the risk of recurrence and progression with both univariate ( log rank test ) and multivariate ( Cox regression ) methods of analysis showed no statistically significance differences . Negative_regulation CDK6 IFI27 15378017 1324013 In the present study , we investigated the consequences of the combined loss of either of two [cyclin dependent kinase] *inhibitors* , p21 and , in cooperation with deletion of the INK4a/ARF locus . Negative_regulation CDK6 IFI27 15474987 1354679 Under the same conditions , adding MG or HK to VD3 or ATRA treatment further enlarged the G0/G1 cell population and increased the expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK6 IFI27 15491288 1321373 In addition , in myeloma cells subjected to growth-factor starvation , the upregulation of PGP9.5 was observed in association with that of ( Kip1 ) , a [cyclin-dependent-kinase] *inhibitor* , although the upregulation caused by irradiation was milder . Negative_regulation CDK6 IFI27 15799773 1390561 Several genes , including insulin-like growth factor 1 (IGF-1) and [cyclin dependent kinase] *inhibitor* ( ( Kip1 ) ) were induced by both injury types and these may have potential clinical application as markers of tissue damage . Negative_regulation CDK6 IFI27 15930262 1414424 Here , we found that VDUP1-/- fibroblast cells proliferated more rapidly compared with wild-type cells with reduced expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK6 IFI27 16020508 1465816 Tregs were blocked from cell cycle progression due to decrease of cyclin E and cyclin A and increase of ( p27kip [cyclin dependent kinase] *inhibitor* ) . Negative_regulation CDK6 IFI27 16039115 1473606 Levels of expression of cyclins , cyclin dependent kinases and [cyclin dependent kinase] *inhibitors* , p21 and , were analysed by western blotting . Negative_regulation CDK6 IFI27 16328436 1503621 [Cyclin dependent kinase] *inhibitors* CIP1 ( p21 ) and KIP1 ( ) in ovarian cancer . Negative_regulation CDK6 IFI27 16427178 1567172 In this study , under treatment with various concentrations of PA in MDA-MB 231 cell line , we checked mRNA levels for cyclin A and cyclin B1 and the protein levels of cyclin A and cyclin B1 , Cdc2 ( cyclin dependent kinases ) , p21 ( waf1/cip1 ) and ( Kip1 ) ( [cyclin dependent kinase] *inhibitors* ) , Cdc25C , Chk2 and Wee1 kinase ( cyclin dependent kinase relative factors ) in cell cycle G2/M phase . Negative_regulation CDK6 IFI27 16436005 1495305 ( kip1 ) , a universal [cyclin dependent kinase] *inhibitor* , is a useful marker for predicting clinical aggressiveness with various human tumors . Negative_regulation CDK6 IFI27 16564150 1555718 In contrast , protein levels of , a [cyclin dependent kinase] *inhibitor* , are increased after induction of ER-stress using tunicamycin . Negative_regulation CDK6 IFI27 17360552 1712755 As proof of principle , we studied the consequence of sporadic loss of , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK6 IFI27 17918155 1843874 Furthermore , we find that the growth inhibitory dose of R1881 leads to increases in the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21 and as well as to G1 arrest . Negative_regulation CDK6 IFI27 17979972 1874282 Terrein was found to downregulate cyclin B1 and Cdc2 without Cdc2 phosphorylation , but upregulated ( KIP1 ) ( p27 ) , a known *inhibitor* of [cyclin dependent kinase] . Negative_regulation CDK6 IFI27 18583941 1953309 Roles of [cyclin dependent kinase] *inhibitors* , p21/Cip1 ( p21 ) and p27/Kip1 ( ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation CDK6 IFI27 19026637 2022726 Activation of ERK1/2 was not affected by MacCM , and neither was the expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK6 IFI27 19147535 2026280 Two [cyclin dependent kinase] *inhibitors* , p18 ( Ink4c ) and ( Kip1 ) , are required for proper cerebellar development . Negative_regulation CDK6 IFI27 19276255 2046191 In retrospective studies , loss of ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has been associated with poor prognosis following colorectal cancer treatment . Negative_regulation CDK6 IFI27 19321452 2073936 Although HSC70 directly bound to ( Kip1 ) ( a [cyclin dependent kinase] *inhibitor* ) , histatin 3 increased the binding between those proteins but not with a peptide capable of binding to HSC70 . Negative_regulation CDK6 IFI27 19538337 2103570 In this study , we examined the role of melatonin on synoviocyte proliferation in primary cultured human fibroblast-like synoviocytes ( FLSs ) by analyzing protein expression of P21 ( CIP1 ) ( P21 ) and ( KIP1 ) ( P27 ) , the [cyclin dependent kinase] *inhibitors* that are important in cell cycle control , and the phosphorylation of mitogen activated protein kinases ( MAPKs ) . Negative_regulation CDK6 IFI27 19598246 2149814 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is also known to demarcate the prosensory region in the cochlear primordium , which consists of the sensory progenitors that have completed their terminal mitoses . Negative_regulation CDK6 IFI27 19720293 2133707 Trastuzumab , a humanized antibody directed against the Her2 receptor , induces the expression of ( kip1 ) , an intranuclear [cyclin dependent kinase] *inhibitor* in some breast cancer cells . Negative_regulation CDK6 IFI27 21443540 2438445 Furthermore , NS expression was associated with cellular proliferation in OSCC cell lines using siRNA , which upregulated , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK6 IFI27 21980125 2502932 Further , deletion of AMPKa2 but not AMPKa1 reduced the level of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , and increased the level of S-phase kinase associated protein 2 ( Skp2 ) , a known E3 ubiquitin ligase for p27 ( Kip1 ) , through activation of p52 nuclear factor kappa B ( NF-?B ) -2 . Negative_regulation CDK6 IFI27 22154697 2563121 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) of the CIP/KIP family , p21 , and p57 , mediate cell cycle inhibition . Negative_regulation CDK6 IFI27 22460505 2637128 Cell cycle analysis indicated thioridazine induced the down-regulation of cyclin D1 , cyclin A and CDK4 , and the induction of p21 and , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK6 IFI27 22851678 2677194 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , ( Kip1 ) , and cyclin D1 . Negative_regulation CDK6 IFI27 23255047 2827357 Skp2 mediated degradation of , a [cyclin dependent kinase] *inhibitor* , is involved in cell cycle regulation . Negative_regulation CDK6 IFI27 23721824 2819708 miR-370 induced proliferation was correlated with the downregulation of [cyclin dependent kinase] *inhibitors* , ( Kip1 ) and p21 ( Cip1 ) , and the upregulation of the cell cycle regulator cyclin D1 . Negative_regulation CDK6 IFI27 23888319 2901999 Our results found that curcumin inhibited cell proliferation , which was associated with upregulation of the [cyclin dependent kinase] *inhibitors* , and p21 , and downregulation of cyclin D1 . Negative_regulation CDK6 IFI27 23944957 2887972 We determined whether proliferation and IL-6 release are abnormal in ASM cells ( ASMCs ) from patients with severe asthma , and whether these features could be mediated by microRNA-221 and microRNA-222 , through modulation of the [cyclin dependent kinase] *inhibitors* , p21 ( WAF1 ) and ( kip1 ) . Negative_regulation CDK6 IFI27 24067984 2867170 Western blot analysis of key cell cycle regulators revealed that K-Rta mediated cell cycle arrest was associated with a decrease in cyclin A and phosphorylated Rb ( pS807/pS811 ) protein levels , both markers of S phase progression , and an increase in protein levels for , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK6 IFI27 24708177 2938872 Recently , STMN1 was reported to interact with , an *inhibitor* of [cyclin dependent kinase] complexes . Negative_regulation CDK6 IFI27 8654372 366874 Expression of Zta results in induction of the tumor suppressor protein , p53 , and the [cyclin dependent kinase] *inhibitors* , p21 and , as well as accumulation of hypophosphorylated pRb . Negative_regulation CDK6 IFI27 8845296 337829 We have examined the level of cyclin E , a G1 cyclin , and , a [cyclin dependent kinase] *inhibitor* , in BALB/c 3T3 cells . Negative_regulation CDK6 IFI27 9325318 456848 In contrast , the same or a larger increase in levels did not *inhibit* Cdk4 or its homologue [Cdk6] , despite extensive binding to these kinases . Negative_regulation CDK6 IFI27 9616167 509583 The identification of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* that contributes to cell cycle arrest and represents a link between extracellular signals and cell cycle , prompted us to study p27 protein in the lymphocytes from 88 patients with B-CLL and 32 patients with other chronic B-lymphoproliferative disorders . Negative_regulation CDK6 IFI27 9746784 532997 The ( kip-1 ) , a [cyclin dependent kinase] *inhibitor* which is important in blocking the cell cycle , was induced more quickly and potently by Ro 25-9716 ( 10 ( -7 ) mol/L , 0 to 5 days ) than by 1,25D3 , suggesting a possible mechanism by which these analogs inhibit proliferation of leukemic growth . Negative_regulation CDK6 IFI27 9891946 558562 Hence , we have determined the cell cycle profile , expressions and activities of the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21CIP1 and , during rat ventricular myocyte development . Negative_regulation CDK6 ITGA9 22138449 2536215 Furthermore , effects of p21 , a [cyclin dependent kinase] *inhibitor* , and integrin a9 ( ) were examined . Negative_regulation CDK6 MAP2K6 10597223 573415 p21Cip1/Waf1 [cyclin dependent kinase] inhibitor ( p21 ) is *inducible* by Raf and ( MAPKK ) , but the level of regulation is unknown . Negative_regulation CDK6 MAP2K6 21871886 2491246 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK6 RARB 21868513 2473724 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Negative_regulation CDK7 CCND1 22851678 2677195 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , p27 ( Kip1 ) , and . Negative_regulation CDK7 CCND1 24399246 2906974 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) ( p21Cip1 , p27Kip1 , p15INK4B ) , and cyclin E were shown to be differentially expressed in latexin overexpressed cells and latexin silenced cells . Negative_regulation CDK7 CDKN1C 11347369 814332 The expression of , a [cyclin dependent kinase] *inhibitor* , is a strong indicator that the cells are exiting the cell cycle and are beginning to differentiate . Negative_regulation CDK7 CDKN1C 11529881 853621 We examine the cell proliferation activity and expression of [cyclin dependent kinase] *inhibitors* of the Cip/Kip family , p21Cip1 , p27Kip1 and , in foetal hamster lungs to determine the expression patterns of the cyclin dependent kinase inhibitors and to clarify the relationship between expression of the cyclin dependent kinase inhibitors and lung development . Negative_regulation CDK7 CDKN1C 15224347 1264953 The expression of ( Kip2 ) , a [cyclin dependent kinase] *inhibitor* that was also in the imprinted region , exhibited some variable increased expression predominantly in hepatic neoplasms from livers of female TG+ rats . Negative_regulation CDK7 CDKN1C 15537824 1367515 In contrast , EGCG accelerates terminal differentiation in normal human epidermal keratinocytes ( NHEK ) mediated partially by up-regulation of , a [cyclin dependent kinase] *inhibitor* that confers growth arrest and differentiation . Negative_regulation CDK7 CDKN1C 16731797 1566010 Differential expression of [cyclin dependent kinase] *inhibitors* , p27Kip1 and , by corticotropin in rat adrenal cortex . Negative_regulation CDK7 CDKN1C 16731797 1566048 An important role for the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p27Kip1 and , in the proliferation and differentiation of adrenal cells has been suggested by their knockout mice , which display adrenal hyperplasia . Negative_regulation CDK7 CDKN1C 18822693 1970542 The aim of this study was to establish the importance of , a unique [cyclin dependent kinase] *inhibitor* , in the oncogenesis of bladder carcinoma . Negative_regulation CDK7 CDKN1C 20503313 2263855 A small number of individuals with BWS ( 5-10 % ) have mutations in , a [cyclin dependent kinase] *inhibitor* of G1 cyclin complexes that functions as a negative regulator of cellular growth and proliferation . Negative_regulation CDK7 CDKN1C 21322636 2443307 p21 was found to be a key regulator of this process , because down-regulation of the [cyclin dependent kinase] *inhibitors* p27 ( CDKN1B/KIP1 ) or p57 ( ) or the tumor suppressor p53 ( TP53/LFS1 ) failed to induce proliferation and subsequent dedifferentiation . Negative_regulation CDK7 CDKN1C 22996691 2679055 Expression of , a BMP10 regulated [cyclin dependent kinase] *inhibitor* , was induced in Myocd-/- hearts , while BMP10 activated cardiogenic transcription factors , including NKX2.5 and MEF2c , were repressed . Negative_regulation CDK7 CDKN1C 7550351 323237 Genomic imprinting of , a [cyclin dependent kinase] *inhibitor* , in mouse . Negative_regulation CDK7 CDKN1C 7729683 302214 Cloning of , a [cyclin dependent kinase] *inhibitor* with unique domain structure and tissue distribution . Negative_regulation CDK7 CDKN1C 8923002 397215 The gene for insulin-like growth factor II (IGF2) is normally expressed from the paternal allele , while H19 and , a [cyclin dependent kinase] *inhibitor* , are expressed from the maternal allele . Negative_regulation CDK7 CDKN1C 9311734 455014 these include the gene for insulin-like growth factor II (IGF2) and H19 , which show abnormal imprint-specific expression and/or methylation in 20 % of BWS patients , and , a [cyclin dependent kinase] *inhibitor* , which we found showed biallelic expression in one of nine BWS patients studied . Negative_regulation CDK7 EPHB2 20855497 2325813 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Negative_regulation CDK7 EPHB2 21871886 2491250 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK7 IFI27 10198213 605042 73-kDa heat shock cognate protein interacts directly with , a [cyclin dependent kinase] *inhibitor* , during G1/S transition . Negative_regulation CDK7 IFI27 10198213 605080 In the present study , we demonstrated that 73hsc ( heat shock cognate protein ) , which belongs to the HSP70 family of molecular chaperones , interacts with , an *inhibitor* of [cyclin dependent kinase] , during G1/S transition . Negative_regulation CDK7 IFI27 10510349 651111 The treatment of macrophages with adenosine induces the expression of , a G1 [cyclin dependent kinase] *inhibitor* , in a protein kinase A-dependent way . Negative_regulation CDK7 IFI27 10859299 715250 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in many types of carcinomas . Negative_regulation CDK7 IFI27 10861499 705308 ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has an important role in the progression of cells from G ( 1 ) into S phase of the cell cycle . Negative_regulation CDK7 IFI27 10903892 713405 Minimal requirements for the nuclear localization of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK7 IFI27 11136238 786712 Previous work has shown that cyclin A can be cleaved at Arg-70/Arg-71 by a proteolytic activity present in an in vitro coupled transcription/translation system by using rabbit reticulocyte lysate programmed by plasmid DNA encoding ( KIP1 ) , a [cyclin dependent kinase] *inhibitor* , but not by plasmid DNAs encoding other cyclin dependent kinases inhibitors . Negative_regulation CDK7 IFI27 11164713 782665 [Cyclin dependent kinase] *inhibitors* , p21 ( waf1/cip1 ) and ( kip1 ) , are expressed site- and hair cycle-dependently in rat hair follicles . Negative_regulation CDK7 IFI27 11237531 790109 A major function of , also known as Kip1 , is to bind and *inhibit* [cyclin/cyclin dependent kinase] complexes , thereby blocking cell cycle progression . Negative_regulation CDK7 IFI27 11251953 793942 Low expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is a marker of poor prognosis in synovial sarcoma . Negative_regulation CDK7 IFI27 11251953 793961 Low expression of ( kip1 ) , a dominant [cyclin dependent kinase] *inhibitor* involved in G1-S transition of the cell cycle , recently has been reported to be associated with aggressive tumor growth . Negative_regulation CDK7 IFI27 11301477 803363 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in breast cancer . Negative_regulation CDK7 IFI27 11400230 824394 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , negatively regulates the G1 phase progression of the cell cycle by binding to the cyclin E/cyclin dependent kinase 2 complex . Negative_regulation CDK7 IFI27 11557117 861247 , a [cyclin dependent kinase] *inhibitor* , regulates the progression from G1 into the S phase by binding and inhibiting cyclin/cdks . Negative_regulation CDK7 IFI27 11744034 897892 Levels of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p16 and , were initially high in quiescent isolated cells and tissue ; Negative_regulation CDK7 IFI27 11745414 888962 Herein , expression of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p21 , and p57 and their associated kinase activities were examined in 61 cases of soft tissue smooth muscle tumors . Negative_regulation CDK7 IFI27 11850846 913188 LY294002 also causes an increase in , a [cyclin dependent kinase] *inhibitor* and results in the dephosphorylation of members of the pocket protein family . Negative_regulation CDK7 IFI27 11856766 914399 The differentiation was accompanied by a growth arrest and the upregulation of [cyclin dependent kinase] *inhibitors* , and p57 , as well as cyclin D(1) , whereas cyclin A was downregulated . Negative_regulation CDK7 IFI27 12097295 961272 Reduced expression level of , a [cyclin dependent kinase] *inhibitor* , is associated with high aggressiveness and poor prognosis of various malignant tumors , including gastric carcinoma . Negative_regulation CDK7 IFI27 12465754 1022259 Calcitriol induces a significant G0/G1 arrest and modulates p21 ( Waf/Cip1 ) and ( Kip1 ) , the [cyclin dependent kinase] *inhibitors* . Negative_regulation CDK7 IFI27 12663518 1074547 IP6 strongly increased the expression of CDKIs ( [cyclin dependent kinase] *inhibitors* ) , Cip1/p21 and , without any noticeable changes in G1 CDKs and cyclins , except a slight increase in cyclin D2 . Negative_regulation CDK7 IFI27 12771291 1094748 Parathyroid cell growth in patients with advanced secondary hyperparathyroidism : vitamin D receptor and [cyclin dependent kinase] *inhibitors* , p21 and . Negative_regulation CDK7 IFI27 12943995 1135797 We also observed a simultaneous increase in the expression of [cyclin-dependent-kinase] *inhibitors* , p21 , , p15 and p16 , associated with a loss in expression of Cyclin-A2 and Cyclin-E . Negative_regulation CDK7 IFI27 14618613 1188022 To examine the mechanism of the troglitazone induced growth inhibition , we determined ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , expression by Western blot analysis in troglitazone treated HLF cells . Negative_regulation CDK7 IFI27 15048878 1225250 We conclude that substrate dependent acquisition of proliferative phenotypes following repeated cycles of AAM injury correlates with modulation of the [cyclin dependent kinase] *inhibitors* , and p21 . Negative_regulation CDK7 IFI27 15138205 1246189 Gastric cells chronically exposed to H pylori in vitro develop resistance to apoptosis associated with low levels of , a [cyclin dependent kinase] *inhibitor* and haplo insufficient tumour suppressor gene that is downregulated in gastric cancer . Negative_regulation CDK7 IFI27 15224009 1264888 A high level of , an *inhibitor* of [cyclin dependent kinase] that correlates with the degree of in vitro apoptosis , is found in B-CLL cells . Negative_regulation CDK7 IFI27 15263796 1275073 The prognostic significance of cyclins D1 , E and [cyclin dependent kinase] *inhibitors* p21 ( Waf1/Cip1 ) , ( Kip1 ) in determining the risk of recurrence and progression with both univariate ( log rank test ) and multivariate ( Cox regression ) methods of analysis showed no statistically significance differences . Negative_regulation CDK7 IFI27 15378017 1324015 In the present study , we investigated the consequences of the combined loss of either of two [cyclin dependent kinase] *inhibitors* , p21 and , in cooperation with deletion of the INK4a/ARF locus . Negative_regulation CDK7 IFI27 15474987 1354680 Under the same conditions , adding MG or HK to VD3 or ATRA treatment further enlarged the G0/G1 cell population and increased the expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK7 IFI27 15491288 1321374 In addition , in myeloma cells subjected to growth-factor starvation , the upregulation of PGP9.5 was observed in association with that of ( Kip1 ) , a [cyclin-dependent-kinase] *inhibitor* , although the upregulation caused by irradiation was milder . Negative_regulation CDK7 IFI27 15799773 1390562 Several genes , including insulin-like growth factor 1 (IGF-1) and [cyclin dependent kinase] *inhibitor* ( ( Kip1 ) ) were induced by both injury types and these may have potential clinical application as markers of tissue damage . Negative_regulation CDK7 IFI27 15930262 1414425 Here , we found that VDUP1-/- fibroblast cells proliferated more rapidly compared with wild-type cells with reduced expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK7 IFI27 16020508 1465818 Tregs were blocked from cell cycle progression due to decrease of cyclin E and cyclin A and increase of ( p27kip [cyclin dependent kinase] *inhibitor* ) . Negative_regulation CDK7 IFI27 16039115 1473608 Levels of expression of cyclins , cyclin dependent kinases and [cyclin dependent kinase] *inhibitors* , p21 and , were analysed by western blotting . Negative_regulation CDK7 IFI27 16328436 1503622 [Cyclin dependent kinase] *inhibitors* CIP1 ( p21 ) and KIP1 ( ) in ovarian cancer . Negative_regulation CDK7 IFI27 16427178 1567174 In this study , under treatment with various concentrations of PA in MDA-MB 231 cell line , we checked mRNA levels for cyclin A and cyclin B1 and the protein levels of cyclin A and cyclin B1 , Cdc2 ( cyclin dependent kinases ) , p21 ( waf1/cip1 ) and ( Kip1 ) ( [cyclin dependent kinase] *inhibitors* ) , Cdc25C , Chk2 and Wee1 kinase ( cyclin dependent kinase relative factors ) in cell cycle G2/M phase . Negative_regulation CDK7 IFI27 16436005 1495306 ( kip1 ) , a universal [cyclin dependent kinase] *inhibitor* , is a useful marker for predicting clinical aggressiveness with various human tumors . Negative_regulation CDK7 IFI27 16564150 1555719 In contrast , protein levels of , a [cyclin dependent kinase] *inhibitor* , are increased after induction of ER-stress using tunicamycin . Negative_regulation CDK7 IFI27 17360552 1712757 As proof of principle , we studied the consequence of sporadic loss of , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK7 IFI27 17918155 1843876 Furthermore , we find that the growth inhibitory dose of R1881 leads to increases in the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21 and as well as to G1 arrest . Negative_regulation CDK7 IFI27 17979972 1874283 Terrein was found to downregulate cyclin B1 and Cdc2 without Cdc2 phosphorylation , but upregulated ( KIP1 ) ( p27 ) , a known *inhibitor* of [cyclin dependent kinase] . Negative_regulation CDK7 IFI27 18583941 1953313 Roles of [cyclin dependent kinase] *inhibitors* , p21/Cip1 ( p21 ) and p27/Kip1 ( ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation CDK7 IFI27 19026637 2022727 Activation of ERK1/2 was not affected by MacCM , and neither was the expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK7 IFI27 19147535 2026282 Two [cyclin dependent kinase] *inhibitors* , p18 ( Ink4c ) and ( Kip1 ) , are required for proper cerebellar development . Negative_regulation CDK7 IFI27 19276255 2046192 In retrospective studies , loss of ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has been associated with poor prognosis following colorectal cancer treatment . Negative_regulation CDK7 IFI27 19321452 2073937 Although HSC70 directly bound to ( Kip1 ) ( a [cyclin dependent kinase] *inhibitor* ) , histatin 3 increased the binding between those proteins but not with a peptide capable of binding to HSC70 . Negative_regulation CDK7 IFI27 19538337 2103572 In this study , we examined the role of melatonin on synoviocyte proliferation in primary cultured human fibroblast-like synoviocytes ( FLSs ) by analyzing protein expression of P21 ( CIP1 ) ( P21 ) and ( KIP1 ) ( P27 ) , the [cyclin dependent kinase] *inhibitors* that are important in cell cycle control , and the phosphorylation of mitogen activated protein kinases ( MAPKs ) . Negative_regulation CDK7 IFI27 19598246 2149815 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is also known to demarcate the prosensory region in the cochlear primordium , which consists of the sensory progenitors that have completed their terminal mitoses . Negative_regulation CDK7 IFI27 19720293 2133708 Trastuzumab , a humanized antibody directed against the Her2 receptor , induces the expression of ( kip1 ) , an intranuclear [cyclin dependent kinase] *inhibitor* in some breast cancer cells . Negative_regulation CDK7 IFI27 21443540 2438446 Furthermore , NS expression was associated with cellular proliferation in OSCC cell lines using siRNA , which upregulated , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK7 IFI27 21980125 2502933 Further , deletion of AMPKa2 but not AMPKa1 reduced the level of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , and increased the level of S-phase kinase associated protein 2 ( Skp2 ) , a known E3 ubiquitin ligase for p27 ( Kip1 ) , through activation of p52 nuclear factor kappa B ( NF-?B ) -2 . Negative_regulation CDK7 IFI27 22154697 2563122 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) of the CIP/KIP family , p21 , and p57 , mediate cell cycle inhibition . Negative_regulation CDK7 IFI27 22460505 2637130 Cell cycle analysis indicated thioridazine induced the down-regulation of cyclin D1 , cyclin A and CDK4 , and the induction of p21 and , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK7 IFI27 22851678 2677197 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , ( Kip1 ) , and cyclin D1 . Negative_regulation CDK7 IFI27 23255047 2827358 Skp2 mediated degradation of , a [cyclin dependent kinase] *inhibitor* , is involved in cell cycle regulation . Negative_regulation CDK7 IFI27 23721824 2819710 miR-370 induced proliferation was correlated with the downregulation of [cyclin dependent kinase] *inhibitors* , ( Kip1 ) and p21 ( Cip1 ) , and the upregulation of the cell cycle regulator cyclin D1 . Negative_regulation CDK7 IFI27 23888319 2902001 Our results found that curcumin inhibited cell proliferation , which was associated with upregulation of the [cyclin dependent kinase] *inhibitors* , and p21 , and downregulation of cyclin D1 . Negative_regulation CDK7 IFI27 23944957 2887974 We determined whether proliferation and IL-6 release are abnormal in ASM cells ( ASMCs ) from patients with severe asthma , and whether these features could be mediated by microRNA-221 and microRNA-222 , through modulation of the [cyclin dependent kinase] *inhibitors* , p21 ( WAF1 ) and ( kip1 ) . Negative_regulation CDK7 IFI27 24067984 2867171 Western blot analysis of key cell cycle regulators revealed that K-Rta mediated cell cycle arrest was associated with a decrease in cyclin A and phosphorylated Rb ( pS807/pS811 ) protein levels , both markers of S phase progression , and an increase in protein levels for , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK7 IFI27 24708177 2938873 Recently , STMN1 was reported to interact with , an *inhibitor* of [cyclin dependent kinase] complexes . Negative_regulation CDK7 IFI27 8654372 366876 Expression of Zta results in induction of the tumor suppressor protein , p53 , and the [cyclin dependent kinase] *inhibitors* , p21 and , as well as accumulation of hypophosphorylated pRb . Negative_regulation CDK7 IFI27 8845296 337832 We have examined the level of cyclin E , a G1 cyclin , and , a [cyclin dependent kinase] *inhibitor* , in BALB/c 3T3 cells . Negative_regulation CDK7 IFI27 9616167 509584 The identification of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* that contributes to cell cycle arrest and represents a link between extracellular signals and cell cycle , prompted us to study p27 protein in the lymphocytes from 88 patients with B-CLL and 32 patients with other chronic B-lymphoproliferative disorders . Negative_regulation CDK7 IFI27 9746784 532998 The ( kip-1 ) , a [cyclin dependent kinase] *inhibitor* which is important in blocking the cell cycle , was induced more quickly and potently by Ro 25-9716 ( 10 ( -7 ) mol/L , 0 to 5 days ) than by 1,25D3 , suggesting a possible mechanism by which these analogs inhibit proliferation of leukemic growth . Negative_regulation CDK7 IFI27 9891946 558566 Hence , we have determined the cell cycle profile , expressions and activities of the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21CIP1 and , during rat ventricular myocyte development . Negative_regulation CDK7 ITGA9 22138449 2536216 Furthermore , effects of p21 , a [cyclin dependent kinase] *inhibitor* , and integrin a9 ( ) were examined . Negative_regulation CDK7 MAP2K6 10597223 573423 p21Cip1/Waf1 [cyclin dependent kinase] inhibitor ( p21 ) is *inducible* by Raf and ( MAPKK ) , but the level of regulation is unknown . Negative_regulation CDK7 MAP2K6 21871886 2491256 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK7 RARB 21868513 2473725 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Negative_regulation CDK8 CCND1 22851678 2677198 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , p27 ( Kip1 ) , and . Negative_regulation CDK8 CCND1 24399246 2906975 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) ( p21Cip1 , p27Kip1 , p15INK4B ) , and cyclin E were shown to be differentially expressed in latexin overexpressed cells and latexin silenced cells . Negative_regulation CDK8 CD14 16574244 1582542 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation CDK8 CDKN1C 11347369 814333 The expression of , a [cyclin dependent kinase] *inhibitor* , is a strong indicator that the cells are exiting the cell cycle and are beginning to differentiate . Negative_regulation CDK8 CDKN1C 11529881 853624 We examine the cell proliferation activity and expression of [cyclin dependent kinase] *inhibitors* of the Cip/Kip family , p21Cip1 , p27Kip1 and , in foetal hamster lungs to determine the expression patterns of the cyclin dependent kinase inhibitors and to clarify the relationship between expression of the cyclin dependent kinase inhibitors and lung development . Negative_regulation CDK8 CDKN1C 15224347 1264954 The expression of ( Kip2 ) , a [cyclin dependent kinase] *inhibitor* that was also in the imprinted region , exhibited some variable increased expression predominantly in hepatic neoplasms from livers of female TG+ rats . Negative_regulation CDK8 CDKN1C 15537824 1367516 In contrast , EGCG accelerates terminal differentiation in normal human epidermal keratinocytes ( NHEK ) mediated partially by up-regulation of , a [cyclin dependent kinase] *inhibitor* that confers growth arrest and differentiation . Negative_regulation CDK8 CDKN1C 16731797 1566012 Differential expression of [cyclin dependent kinase] *inhibitors* , p27Kip1 and , by corticotropin in rat adrenal cortex . Negative_regulation CDK8 CDKN1C 16731797 1566050 An important role for the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p27Kip1 and , in the proliferation and differentiation of adrenal cells has been suggested by their knockout mice , which display adrenal hyperplasia . Negative_regulation CDK8 CDKN1C 18822693 1970543 The aim of this study was to establish the importance of , a unique [cyclin dependent kinase] *inhibitor* , in the oncogenesis of bladder carcinoma . Negative_regulation CDK8 CDKN1C 20503313 2263856 A small number of individuals with BWS ( 5-10 % ) have mutations in , a [cyclin dependent kinase] *inhibitor* of G1 cyclin complexes that functions as a negative regulator of cellular growth and proliferation . Negative_regulation CDK8 CDKN1C 21322636 2443309 p21 was found to be a key regulator of this process , because down-regulation of the [cyclin dependent kinase] *inhibitors* p27 ( CDKN1B/KIP1 ) or p57 ( ) or the tumor suppressor p53 ( TP53/LFS1 ) failed to induce proliferation and subsequent dedifferentiation . Negative_regulation CDK8 CDKN1C 22996691 2679056 Expression of , a BMP10 regulated [cyclin dependent kinase] *inhibitor* , was induced in Myocd-/- hearts , while BMP10 activated cardiogenic transcription factors , including NKX2.5 and MEF2c , were repressed . Negative_regulation CDK8 CDKN1C 7550351 323238 Genomic imprinting of , a [cyclin dependent kinase] *inhibitor* , in mouse . Negative_regulation CDK8 CDKN1C 7729683 302215 Cloning of , a [cyclin dependent kinase] *inhibitor* with unique domain structure and tissue distribution . Negative_regulation CDK8 CDKN1C 8923002 397217 The gene for insulin-like growth factor II (IGF2) is normally expressed from the paternal allele , while H19 and , a [cyclin dependent kinase] *inhibitor* , are expressed from the maternal allele . Negative_regulation CDK8 CDKN1C 9311734 455015 these include the gene for insulin-like growth factor II (IGF2) and H19 , which show abnormal imprint-specific expression and/or methylation in 20 % of BWS patients , and , a [cyclin dependent kinase] *inhibitor* , which we found showed biallelic expression in one of nine BWS patients studied . Negative_regulation CDK8 EPHB2 20855497 2325816 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Negative_regulation CDK8 EPHB2 21871886 2491260 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK8 IFI27 10198213 605044 73-kDa heat shock cognate protein interacts directly with , a [cyclin dependent kinase] *inhibitor* , during G1/S transition . Negative_regulation CDK8 IFI27 10198213 605082 In the present study , we demonstrated that 73hsc ( heat shock cognate protein ) , which belongs to the HSP70 family of molecular chaperones , interacts with , an *inhibitor* of [cyclin dependent kinase] , during G1/S transition . Negative_regulation CDK8 IFI27 10510349 651113 The treatment of macrophages with adenosine induces the expression of , a G1 [cyclin dependent kinase] *inhibitor* , in a protein kinase A-dependent way . Negative_regulation CDK8 IFI27 10859299 715251 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in many types of carcinomas . Negative_regulation CDK8 IFI27 10861499 705309 ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has an important role in the progression of cells from G ( 1 ) into S phase of the cell cycle . Negative_regulation CDK8 IFI27 10903892 713406 Minimal requirements for the nuclear localization of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK8 IFI27 11136238 786713 Previous work has shown that cyclin A can be cleaved at Arg-70/Arg-71 by a proteolytic activity present in an in vitro coupled transcription/translation system by using rabbit reticulocyte lysate programmed by plasmid DNA encoding ( KIP1 ) , a [cyclin dependent kinase] *inhibitor* , but not by plasmid DNAs encoding other cyclin dependent kinases inhibitors . Negative_regulation CDK8 IFI27 11164713 782667 [Cyclin dependent kinase] *inhibitors* , p21 ( waf1/cip1 ) and ( kip1 ) , are expressed site- and hair cycle-dependently in rat hair follicles . Negative_regulation CDK8 IFI27 11237531 790110 A major function of , also known as Kip1 , is to bind and *inhibit* [cyclin/cyclin dependent kinase] complexes , thereby blocking cell cycle progression . Negative_regulation CDK8 IFI27 11251953 793943 Low expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is a marker of poor prognosis in synovial sarcoma . Negative_regulation CDK8 IFI27 11251953 793962 Low expression of ( kip1 ) , a dominant [cyclin dependent kinase] *inhibitor* involved in G1-S transition of the cell cycle , recently has been reported to be associated with aggressive tumor growth . Negative_regulation CDK8 IFI27 11301477 803364 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in breast cancer . Negative_regulation CDK8 IFI27 11400230 824395 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , negatively regulates the G1 phase progression of the cell cycle by binding to the cyclin E/cyclin dependent kinase 2 complex . Negative_regulation CDK8 IFI27 11557117 861248 , a [cyclin dependent kinase] *inhibitor* , regulates the progression from G1 into the S phase by binding and inhibiting cyclin/cdks . Negative_regulation CDK8 IFI27 11744034 897893 Levels of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p16 and , were initially high in quiescent isolated cells and tissue ; Negative_regulation CDK8 IFI27 11745414 888963 Herein , expression of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p21 , and p57 and their associated kinase activities were examined in 61 cases of soft tissue smooth muscle tumors . Negative_regulation CDK8 IFI27 11850846 913190 LY294002 also causes an increase in , a [cyclin dependent kinase] *inhibitor* and results in the dephosphorylation of members of the pocket protein family . Negative_regulation CDK8 IFI27 11856766 914400 The differentiation was accompanied by a growth arrest and the upregulation of [cyclin dependent kinase] *inhibitors* , and p57 , as well as cyclin D(1) , whereas cyclin A was downregulated . Negative_regulation CDK8 IFI27 12097295 961273 Reduced expression level of , a [cyclin dependent kinase] *inhibitor* , is associated with high aggressiveness and poor prognosis of various malignant tumors , including gastric carcinoma . Negative_regulation CDK8 IFI27 12465754 1022261 Calcitriol induces a significant G0/G1 arrest and modulates p21 ( Waf/Cip1 ) and ( Kip1 ) , the [cyclin dependent kinase] *inhibitors* . Negative_regulation CDK8 IFI27 12663518 1074551 IP6 strongly increased the expression of CDKIs ( [cyclin dependent kinase] *inhibitors* ) , Cip1/p21 and , without any noticeable changes in G1 CDKs and cyclins , except a slight increase in cyclin D2 . Negative_regulation CDK8 IFI27 12771291 1094750 Parathyroid cell growth in patients with advanced secondary hyperparathyroidism : vitamin D receptor and [cyclin dependent kinase] *inhibitors* , p21 and . Negative_regulation CDK8 IFI27 12943995 1135799 We also observed a simultaneous increase in the expression of [cyclin-dependent-kinase] *inhibitors* , p21 , , p15 and p16 , associated with a loss in expression of Cyclin-A2 and Cyclin-E . Negative_regulation CDK8 IFI27 14618613 1188023 To examine the mechanism of the troglitazone induced growth inhibition , we determined ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , expression by Western blot analysis in troglitazone treated HLF cells . Negative_regulation CDK8 IFI27 15048878 1225252 We conclude that substrate dependent acquisition of proliferative phenotypes following repeated cycles of AAM injury correlates with modulation of the [cyclin dependent kinase] *inhibitors* , and p21 . Negative_regulation CDK8 IFI27 15138205 1246190 Gastric cells chronically exposed to H pylori in vitro develop resistance to apoptosis associated with low levels of , a [cyclin dependent kinase] *inhibitor* and haplo insufficient tumour suppressor gene that is downregulated in gastric cancer . Negative_regulation CDK8 IFI27 15224009 1264890 A high level of , an *inhibitor* of [cyclin dependent kinase] that correlates with the degree of in vitro apoptosis , is found in B-CLL cells . Negative_regulation CDK8 IFI27 15263796 1275074 The prognostic significance of cyclins D1 , E and [cyclin dependent kinase] *inhibitors* p21 ( Waf1/Cip1 ) , ( Kip1 ) in determining the risk of recurrence and progression with both univariate ( log rank test ) and multivariate ( Cox regression ) methods of analysis showed no statistically significance differences . Negative_regulation CDK8 IFI27 15378017 1324017 In the present study , we investigated the consequences of the combined loss of either of two [cyclin dependent kinase] *inhibitors* , p21 and , in cooperation with deletion of the INK4a/ARF locus . Negative_regulation CDK8 IFI27 15474987 1354681 Under the same conditions , adding MG or HK to VD3 or ATRA treatment further enlarged the G0/G1 cell population and increased the expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK8 IFI27 15491288 1321375 In addition , in myeloma cells subjected to growth-factor starvation , the upregulation of PGP9.5 was observed in association with that of ( Kip1 ) , a [cyclin-dependent-kinase] *inhibitor* , although the upregulation caused by irradiation was milder . Negative_regulation CDK8 IFI27 15799773 1390563 Several genes , including insulin-like growth factor 1 (IGF-1) and [cyclin dependent kinase] *inhibitor* ( ( Kip1 ) ) were induced by both injury types and these may have potential clinical application as markers of tissue damage . Negative_regulation CDK8 IFI27 15930262 1414426 Here , we found that VDUP1-/- fibroblast cells proliferated more rapidly compared with wild-type cells with reduced expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK8 IFI27 16020508 1465820 Tregs were blocked from cell cycle progression due to decrease of cyclin E and cyclin A and increase of ( p27kip [cyclin dependent kinase] *inhibitor* ) . Negative_regulation CDK8 IFI27 16039115 1473610 Levels of expression of cyclins , cyclin dependent kinases and [cyclin dependent kinase] *inhibitors* , p21 and , were analysed by western blotting . Negative_regulation CDK8 IFI27 16328436 1503623 [Cyclin dependent kinase] *inhibitors* CIP1 ( p21 ) and KIP1 ( ) in ovarian cancer . Negative_regulation CDK8 IFI27 16427178 1567176 In this study , under treatment with various concentrations of PA in MDA-MB 231 cell line , we checked mRNA levels for cyclin A and cyclin B1 and the protein levels of cyclin A and cyclin B1 , Cdc2 ( cyclin dependent kinases ) , p21 ( waf1/cip1 ) and ( Kip1 ) ( [cyclin dependent kinase] *inhibitors* ) , Cdc25C , Chk2 and Wee1 kinase ( cyclin dependent kinase relative factors ) in cell cycle G2/M phase . Negative_regulation CDK8 IFI27 16436005 1495307 ( kip1 ) , a universal [cyclin dependent kinase] *inhibitor* , is a useful marker for predicting clinical aggressiveness with various human tumors . Negative_regulation CDK8 IFI27 16564150 1555720 In contrast , protein levels of , a [cyclin dependent kinase] *inhibitor* , are increased after induction of ER-stress using tunicamycin . Negative_regulation CDK8 IFI27 17360552 1712759 As proof of principle , we studied the consequence of sporadic loss of , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK8 IFI27 17918155 1843878 Furthermore , we find that the growth inhibitory dose of R1881 leads to increases in the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21 and as well as to G1 arrest . Negative_regulation CDK8 IFI27 17979972 1874284 Terrein was found to downregulate cyclin B1 and Cdc2 without Cdc2 phosphorylation , but upregulated ( KIP1 ) ( p27 ) , a known *inhibitor* of [cyclin dependent kinase] . Negative_regulation CDK8 IFI27 18583941 1953317 Roles of [cyclin dependent kinase] *inhibitors* , p21/Cip1 ( p21 ) and p27/Kip1 ( ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation CDK8 IFI27 19026637 2022728 Activation of ERK1/2 was not affected by MacCM , and neither was the expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK8 IFI27 19147535 2026284 Two [cyclin dependent kinase] *inhibitors* , p18 ( Ink4c ) and ( Kip1 ) , are required for proper cerebellar development . Negative_regulation CDK8 IFI27 19276255 2046193 In retrospective studies , loss of ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has been associated with poor prognosis following colorectal cancer treatment . Negative_regulation CDK8 IFI27 19321452 2073938 Although HSC70 directly bound to ( Kip1 ) ( a [cyclin dependent kinase] *inhibitor* ) , histatin 3 increased the binding between those proteins but not with a peptide capable of binding to HSC70 . Negative_regulation CDK8 IFI27 19538337 2103574 In this study , we examined the role of melatonin on synoviocyte proliferation in primary cultured human fibroblast-like synoviocytes ( FLSs ) by analyzing protein expression of P21 ( CIP1 ) ( P21 ) and ( KIP1 ) ( P27 ) , the [cyclin dependent kinase] *inhibitors* that are important in cell cycle control , and the phosphorylation of mitogen activated protein kinases ( MAPKs ) . Negative_regulation CDK8 IFI27 19598246 2149816 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is also known to demarcate the prosensory region in the cochlear primordium , which consists of the sensory progenitors that have completed their terminal mitoses . Negative_regulation CDK8 IFI27 19720293 2133709 Trastuzumab , a humanized antibody directed against the Her2 receptor , induces the expression of ( kip1 ) , an intranuclear [cyclin dependent kinase] *inhibitor* in some breast cancer cells . Negative_regulation CDK8 IFI27 21443540 2438447 Furthermore , NS expression was associated with cellular proliferation in OSCC cell lines using siRNA , which upregulated , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK8 IFI27 21980125 2502934 Further , deletion of AMPKa2 but not AMPKa1 reduced the level of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , and increased the level of S-phase kinase associated protein 2 ( Skp2 ) , a known E3 ubiquitin ligase for p27 ( Kip1 ) , through activation of p52 nuclear factor kappa B ( NF-?B ) -2 . Negative_regulation CDK8 IFI27 22154697 2563123 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) of the CIP/KIP family , p21 , and p57 , mediate cell cycle inhibition . Negative_regulation CDK8 IFI27 22460505 2637132 Cell cycle analysis indicated thioridazine induced the down-regulation of cyclin D1 , cyclin A and CDK4 , and the induction of p21 and , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK8 IFI27 22851678 2677200 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , ( Kip1 ) , and cyclin D1 . Negative_regulation CDK8 IFI27 23255047 2827359 Skp2 mediated degradation of , a [cyclin dependent kinase] *inhibitor* , is involved in cell cycle regulation . Negative_regulation CDK8 IFI27 23721824 2819712 miR-370 induced proliferation was correlated with the downregulation of [cyclin dependent kinase] *inhibitors* , ( Kip1 ) and p21 ( Cip1 ) , and the upregulation of the cell cycle regulator cyclin D1 . Negative_regulation CDK8 IFI27 23888319 2902003 Our results found that curcumin inhibited cell proliferation , which was associated with upregulation of the [cyclin dependent kinase] *inhibitors* , and p21 , and downregulation of cyclin D1 . Negative_regulation CDK8 IFI27 23944957 2887976 We determined whether proliferation and IL-6 release are abnormal in ASM cells ( ASMCs ) from patients with severe asthma , and whether these features could be mediated by microRNA-221 and microRNA-222 , through modulation of the [cyclin dependent kinase] *inhibitors* , p21 ( WAF1 ) and ( kip1 ) . Negative_regulation CDK8 IFI27 24067984 2867172 Western blot analysis of key cell cycle regulators revealed that K-Rta mediated cell cycle arrest was associated with a decrease in cyclin A and phosphorylated Rb ( pS807/pS811 ) protein levels , both markers of S phase progression , and an increase in protein levels for , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK8 IFI27 24708177 2938874 Recently , STMN1 was reported to interact with , an *inhibitor* of [cyclin dependent kinase] complexes . Negative_regulation CDK8 IFI27 8654372 366878 Expression of Zta results in induction of the tumor suppressor protein , p53 , and the [cyclin dependent kinase] *inhibitors* , p21 and , as well as accumulation of hypophosphorylated pRb . Negative_regulation CDK8 IFI27 8845296 337835 We have examined the level of cyclin E , a G1 cyclin , and , a [cyclin dependent kinase] *inhibitor* , in BALB/c 3T3 cells . Negative_regulation CDK8 IFI27 9616167 509585 The identification of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* that contributes to cell cycle arrest and represents a link between extracellular signals and cell cycle , prompted us to study p27 protein in the lymphocytes from 88 patients with B-CLL and 32 patients with other chronic B-lymphoproliferative disorders . Negative_regulation CDK8 IFI27 9746784 532999 The ( kip-1 ) , a [cyclin dependent kinase] *inhibitor* which is important in blocking the cell cycle , was induced more quickly and potently by Ro 25-9716 ( 10 ( -7 ) mol/L , 0 to 5 days ) than by 1,25D3 , suggesting a possible mechanism by which these analogs inhibit proliferation of leukemic growth . Negative_regulation CDK8 IFI27 9891946 558570 Hence , we have determined the cell cycle profile , expressions and activities of the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21CIP1 and , during rat ventricular myocyte development . Negative_regulation CDK8 ITGA9 22138449 2536217 Furthermore , effects of p21 , a [cyclin dependent kinase] *inhibitor* , and integrin a9 ( ) were examined . Negative_regulation CDK8 LBP 16574244 1582543 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation CDK8 MAP2K6 10597223 573431 p21Cip1/Waf1 [cyclin dependent kinase] inhibitor ( p21 ) is *inducible* by Raf and ( MAPKK ) , but the level of regulation is unknown . Negative_regulation CDK8 MAP2K6 21871886 2491266 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK8 MSX1 17130681 1653064 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation CDK8 RARB 21868513 2473726 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Negative_regulation CDK8 TNF 14550746 1152696 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation CDK8 TNF 16874302 1600731 Upon *stimulation* of the cells by , NF-kappaB and TFIIH are rapidly recruited to the promoter together with additional Mediator and RNAP II , but [CDK8] is lost . Negative_regulation CDK9 CCND1 22851678 2677201 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , p27 ( Kip1 ) , and . Negative_regulation CDK9 CCND1 24399246 2906976 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) ( p21Cip1 , p27Kip1 , p15INK4B ) , and cyclin E were shown to be differentially expressed in latexin overexpressed cells and latexin silenced cells . Negative_regulation CDK9 CDKN1C 11347369 814334 The expression of , a [cyclin dependent kinase] *inhibitor* , is a strong indicator that the cells are exiting the cell cycle and are beginning to differentiate . Negative_regulation CDK9 CDKN1C 11529881 853627 We examine the cell proliferation activity and expression of [cyclin dependent kinase] *inhibitors* of the Cip/Kip family , p21Cip1 , p27Kip1 and , in foetal hamster lungs to determine the expression patterns of the cyclin dependent kinase inhibitors and to clarify the relationship between expression of the cyclin dependent kinase inhibitors and lung development . Negative_regulation CDK9 CDKN1C 15224347 1264955 The expression of ( Kip2 ) , a [cyclin dependent kinase] *inhibitor* that was also in the imprinted region , exhibited some variable increased expression predominantly in hepatic neoplasms from livers of female TG+ rats . Negative_regulation CDK9 CDKN1C 15537824 1367517 In contrast , EGCG accelerates terminal differentiation in normal human epidermal keratinocytes ( NHEK ) mediated partially by up-regulation of , a [cyclin dependent kinase] *inhibitor* that confers growth arrest and differentiation . Negative_regulation CDK9 CDKN1C 16731797 1566014 Differential expression of [cyclin dependent kinase] *inhibitors* , p27Kip1 and , by corticotropin in rat adrenal cortex . Negative_regulation CDK9 CDKN1C 16731797 1566052 An important role for the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p27Kip1 and , in the proliferation and differentiation of adrenal cells has been suggested by their knockout mice , which display adrenal hyperplasia . Negative_regulation CDK9 CDKN1C 18822693 1970544 The aim of this study was to establish the importance of , a unique [cyclin dependent kinase] *inhibitor* , in the oncogenesis of bladder carcinoma . Negative_regulation CDK9 CDKN1C 20503313 2263857 A small number of individuals with BWS ( 5-10 % ) have mutations in , a [cyclin dependent kinase] *inhibitor* of G1 cyclin complexes that functions as a negative regulator of cellular growth and proliferation . Negative_regulation CDK9 CDKN1C 21322636 2443311 p21 was found to be a key regulator of this process , because down-regulation of the [cyclin dependent kinase] *inhibitors* p27 ( CDKN1B/KIP1 ) or p57 ( ) or the tumor suppressor p53 ( TP53/LFS1 ) failed to induce proliferation and subsequent dedifferentiation . Negative_regulation CDK9 CDKN1C 22996691 2679057 Expression of , a BMP10 regulated [cyclin dependent kinase] *inhibitor* , was induced in Myocd-/- hearts , while BMP10 activated cardiogenic transcription factors , including NKX2.5 and MEF2c , were repressed . Negative_regulation CDK9 CDKN1C 7550351 323239 Genomic imprinting of , a [cyclin dependent kinase] *inhibitor* , in mouse . Negative_regulation CDK9 CDKN1C 7729683 302216 Cloning of , a [cyclin dependent kinase] *inhibitor* with unique domain structure and tissue distribution . Negative_regulation CDK9 CDKN1C 8923002 397219 The gene for insulin-like growth factor II (IGF2) is normally expressed from the paternal allele , while H19 and , a [cyclin dependent kinase] *inhibitor* , are expressed from the maternal allele . Negative_regulation CDK9 CDKN1C 9311734 455016 these include the gene for insulin-like growth factor II (IGF2) and H19 , which show abnormal imprint-specific expression and/or methylation in 20 % of BWS patients , and , a [cyclin dependent kinase] *inhibitor* , which we found showed biallelic expression in one of nine BWS patients studied . Negative_regulation CDK9 EPHB2 20855497 2325819 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Negative_regulation CDK9 EPHB2 21871886 2491270 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK9 IFI27 10198213 605046 73-kDa heat shock cognate protein interacts directly with , a [cyclin dependent kinase] *inhibitor* , during G1/S transition . Negative_regulation CDK9 IFI27 10198213 605084 In the present study , we demonstrated that 73hsc ( heat shock cognate protein ) , which belongs to the HSP70 family of molecular chaperones , interacts with , an *inhibitor* of [cyclin dependent kinase] , during G1/S transition . Negative_regulation CDK9 IFI27 10510349 651115 The treatment of macrophages with adenosine induces the expression of , a G1 [cyclin dependent kinase] *inhibitor* , in a protein kinase A-dependent way . Negative_regulation CDK9 IFI27 10859299 715252 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in many types of carcinomas . Negative_regulation CDK9 IFI27 10861499 705310 ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has an important role in the progression of cells from G ( 1 ) into S phase of the cell cycle . Negative_regulation CDK9 IFI27 10903892 713407 Minimal requirements for the nuclear localization of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK9 IFI27 11136238 786714 Previous work has shown that cyclin A can be cleaved at Arg-70/Arg-71 by a proteolytic activity present in an in vitro coupled transcription/translation system by using rabbit reticulocyte lysate programmed by plasmid DNA encoding ( KIP1 ) , a [cyclin dependent kinase] *inhibitor* , but not by plasmid DNAs encoding other cyclin dependent kinases inhibitors . Negative_regulation CDK9 IFI27 11164713 782669 [Cyclin dependent kinase] *inhibitors* , p21 ( waf1/cip1 ) and ( kip1 ) , are expressed site- and hair cycle-dependently in rat hair follicles . Negative_regulation CDK9 IFI27 11237531 790111 A major function of , also known as Kip1 , is to bind and *inhibit* [cyclin/cyclin dependent kinase] complexes , thereby blocking cell cycle progression . Negative_regulation CDK9 IFI27 11251953 793944 Low expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is a marker of poor prognosis in synovial sarcoma . Negative_regulation CDK9 IFI27 11251953 793963 Low expression of ( kip1 ) , a dominant [cyclin dependent kinase] *inhibitor* involved in G1-S transition of the cell cycle , recently has been reported to be associated with aggressive tumor growth . Negative_regulation CDK9 IFI27 11301477 803365 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , correlates with poor clinical outcome in breast cancer . Negative_regulation CDK9 IFI27 11400230 824396 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , negatively regulates the G1 phase progression of the cell cycle by binding to the cyclin E/cyclin dependent kinase 2 complex . Negative_regulation CDK9 IFI27 11557117 861249 , a [cyclin dependent kinase] *inhibitor* , regulates the progression from G1 into the S phase by binding and inhibiting cyclin/cdks . Negative_regulation CDK9 IFI27 11744034 897894 Levels of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p16 and , were initially high in quiescent isolated cells and tissue ; Negative_regulation CDK9 IFI27 11745414 888964 Herein , expression of the [cyclin dependent kinase] *inhibitors* ( CKIs ) , p21 , and p57 and their associated kinase activities were examined in 61 cases of soft tissue smooth muscle tumors . Negative_regulation CDK9 IFI27 11850846 913192 LY294002 also causes an increase in , a [cyclin dependent kinase] *inhibitor* and results in the dephosphorylation of members of the pocket protein family . Negative_regulation CDK9 IFI27 11856766 914401 The differentiation was accompanied by a growth arrest and the upregulation of [cyclin dependent kinase] *inhibitors* , and p57 , as well as cyclin D(1) , whereas cyclin A was downregulated . Negative_regulation CDK9 IFI27 12097295 961274 Reduced expression level of , a [cyclin dependent kinase] *inhibitor* , is associated with high aggressiveness and poor prognosis of various malignant tumors , including gastric carcinoma . Negative_regulation CDK9 IFI27 12465754 1022263 Calcitriol induces a significant G0/G1 arrest and modulates p21 ( Waf/Cip1 ) and ( Kip1 ) , the [cyclin dependent kinase] *inhibitors* . Negative_regulation CDK9 IFI27 12663518 1074555 IP6 strongly increased the expression of CDKIs ( [cyclin dependent kinase] *inhibitors* ) , Cip1/p21 and , without any noticeable changes in G1 CDKs and cyclins , except a slight increase in cyclin D2 . Negative_regulation CDK9 IFI27 12771291 1094752 Parathyroid cell growth in patients with advanced secondary hyperparathyroidism : vitamin D receptor and [cyclin dependent kinase] *inhibitors* , p21 and . Negative_regulation CDK9 IFI27 12943995 1135801 We also observed a simultaneous increase in the expression of [cyclin-dependent-kinase] *inhibitors* , p21 , , p15 and p16 , associated with a loss in expression of Cyclin-A2 and Cyclin-E . Negative_regulation CDK9 IFI27 14618613 1188024 To examine the mechanism of the troglitazone induced growth inhibition , we determined ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , expression by Western blot analysis in troglitazone treated HLF cells . Negative_regulation CDK9 IFI27 15048878 1225254 We conclude that substrate dependent acquisition of proliferative phenotypes following repeated cycles of AAM injury correlates with modulation of the [cyclin dependent kinase] *inhibitors* , and p21 . Negative_regulation CDK9 IFI27 15138205 1246191 Gastric cells chronically exposed to H pylori in vitro develop resistance to apoptosis associated with low levels of , a [cyclin dependent kinase] *inhibitor* and haplo insufficient tumour suppressor gene that is downregulated in gastric cancer . Negative_regulation CDK9 IFI27 15224009 1264892 A high level of , an *inhibitor* of [cyclin dependent kinase] that correlates with the degree of in vitro apoptosis , is found in B-CLL cells . Negative_regulation CDK9 IFI27 15263796 1275075 The prognostic significance of cyclins D1 , E and [cyclin dependent kinase] *inhibitors* p21 ( Waf1/Cip1 ) , ( Kip1 ) in determining the risk of recurrence and progression with both univariate ( log rank test ) and multivariate ( Cox regression ) methods of analysis showed no statistically significance differences . Negative_regulation CDK9 IFI27 15378017 1324019 In the present study , we investigated the consequences of the combined loss of either of two [cyclin dependent kinase] *inhibitors* , p21 and , in cooperation with deletion of the INK4a/ARF locus . Negative_regulation CDK9 IFI27 15474987 1354682 Under the same conditions , adding MG or HK to VD3 or ATRA treatment further enlarged the G0/G1 cell population and increased the expression of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK9 IFI27 15491288 1321376 In addition , in myeloma cells subjected to growth-factor starvation , the upregulation of PGP9.5 was observed in association with that of ( Kip1 ) , a [cyclin-dependent-kinase] *inhibitor* , although the upregulation caused by irradiation was milder . Negative_regulation CDK9 IFI27 15799773 1390564 Several genes , including insulin-like growth factor 1 (IGF-1) and [cyclin dependent kinase] *inhibitor* ( ( Kip1 ) ) were induced by both injury types and these may have potential clinical application as markers of tissue damage . Negative_regulation CDK9 IFI27 15930262 1414427 Here , we found that VDUP1-/- fibroblast cells proliferated more rapidly compared with wild-type cells with reduced expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK9 IFI27 16020508 1465822 Tregs were blocked from cell cycle progression due to decrease of cyclin E and cyclin A and increase of ( p27kip [cyclin dependent kinase] *inhibitor* ) . Negative_regulation CDK9 IFI27 16039115 1473612 Levels of expression of cyclins , cyclin dependent kinases and [cyclin dependent kinase] *inhibitors* , p21 and , were analysed by western blotting . Negative_regulation CDK9 IFI27 16328436 1503624 [Cyclin dependent kinase] *inhibitors* CIP1 ( p21 ) and KIP1 ( ) in ovarian cancer . Negative_regulation CDK9 IFI27 16427178 1567178 In this study , under treatment with various concentrations of PA in MDA-MB 231 cell line , we checked mRNA levels for cyclin A and cyclin B1 and the protein levels of cyclin A and cyclin B1 , Cdc2 ( cyclin dependent kinases ) , p21 ( waf1/cip1 ) and ( Kip1 ) ( [cyclin dependent kinase] *inhibitors* ) , Cdc25C , Chk2 and Wee1 kinase ( cyclin dependent kinase relative factors ) in cell cycle G2/M phase . Negative_regulation CDK9 IFI27 16436005 1495308 ( kip1 ) , a universal [cyclin dependent kinase] *inhibitor* , is a useful marker for predicting clinical aggressiveness with various human tumors . Negative_regulation CDK9 IFI27 16564150 1555721 In contrast , protein levels of , a [cyclin dependent kinase] *inhibitor* , are increased after induction of ER-stress using tunicamycin . Negative_regulation CDK9 IFI27 17360552 1712761 As proof of principle , we studied the consequence of sporadic loss of , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK9 IFI27 17918155 1843880 Furthermore , we find that the growth inhibitory dose of R1881 leads to increases in the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21 and as well as to G1 arrest . Negative_regulation CDK9 IFI27 17979972 1874285 Terrein was found to downregulate cyclin B1 and Cdc2 without Cdc2 phosphorylation , but upregulated ( KIP1 ) ( p27 ) , a known *inhibitor* of [cyclin dependent kinase] . Negative_regulation CDK9 IFI27 18583941 1953321 Roles of [cyclin dependent kinase] *inhibitors* , p21/Cip1 ( p21 ) and p27/Kip1 ( ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation CDK9 IFI27 19026637 2022729 Activation of ERK1/2 was not affected by MacCM , and neither was the expression of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK9 IFI27 19147535 2026286 Two [cyclin dependent kinase] *inhibitors* , p18 ( Ink4c ) and ( Kip1 ) , are required for proper cerebellar development . Negative_regulation CDK9 IFI27 19276255 2046194 In retrospective studies , loss of ( Kip1 ) ( p27 ) , a [cyclin dependent kinase] *inhibitor* , has been associated with poor prognosis following colorectal cancer treatment . Negative_regulation CDK9 IFI27 19321452 2073939 Although HSC70 directly bound to ( Kip1 ) ( a [cyclin dependent kinase] *inhibitor* ) , histatin 3 increased the binding between those proteins but not with a peptide capable of binding to HSC70 . Negative_regulation CDK9 IFI27 19538337 2103576 In this study , we examined the role of melatonin on synoviocyte proliferation in primary cultured human fibroblast-like synoviocytes ( FLSs ) by analyzing protein expression of P21 ( CIP1 ) ( P21 ) and ( KIP1 ) ( P27 ) , the [cyclin dependent kinase] *inhibitors* that are important in cell cycle control , and the phosphorylation of mitogen activated protein kinases ( MAPKs ) . Negative_regulation CDK9 IFI27 19598246 2149817 ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , is also known to demarcate the prosensory region in the cochlear primordium , which consists of the sensory progenitors that have completed their terminal mitoses . Negative_regulation CDK9 IFI27 19720293 2133710 Trastuzumab , a humanized antibody directed against the Her2 receptor , induces the expression of ( kip1 ) , an intranuclear [cyclin dependent kinase] *inhibitor* in some breast cancer cells . Negative_regulation CDK9 IFI27 21443540 2438448 Furthermore , NS expression was associated with cellular proliferation in OSCC cell lines using siRNA , which upregulated , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK9 IFI27 21980125 2502935 Further , deletion of AMPKa2 but not AMPKa1 reduced the level of ( Kip1 ) , a [cyclin dependent kinase] *inhibitor* , and increased the level of S-phase kinase associated protein 2 ( Skp2 ) , a known E3 ubiquitin ligase for p27 ( Kip1 ) , through activation of p52 nuclear factor kappa B ( NF-?B ) -2 . Negative_regulation CDK9 IFI27 22154697 2563124 The [cyclin dependent kinase] *inhibitors* ( CDKIs ) of the CIP/KIP family , p21 , and p57 , mediate cell cycle inhibition . Negative_regulation CDK9 IFI27 22460505 2637134 Cell cycle analysis indicated thioridazine induced the down-regulation of cyclin D1 , cyclin A and CDK4 , and the induction of p21 and , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK9 IFI27 22851678 2677203 Differential cell cycle regulator expression included [cyclin dependent kinase] *inhibitors* , p21 ( Cip1 ) , ( Kip1 ) , and cyclin D1 . Negative_regulation CDK9 IFI27 23255047 2827360 Skp2 mediated degradation of , a [cyclin dependent kinase] *inhibitor* , is involved in cell cycle regulation . Negative_regulation CDK9 IFI27 23721824 2819714 miR-370 induced proliferation was correlated with the downregulation of [cyclin dependent kinase] *inhibitors* , ( Kip1 ) and p21 ( Cip1 ) , and the upregulation of the cell cycle regulator cyclin D1 . Negative_regulation CDK9 IFI27 23888319 2902005 Our results found that curcumin inhibited cell proliferation , which was associated with upregulation of the [cyclin dependent kinase] *inhibitors* , and p21 , and downregulation of cyclin D1 . Negative_regulation CDK9 IFI27 23944957 2887978 We determined whether proliferation and IL-6 release are abnormal in ASM cells ( ASMCs ) from patients with severe asthma , and whether these features could be mediated by microRNA-221 and microRNA-222 , through modulation of the [cyclin dependent kinase] *inhibitors* , p21 ( WAF1 ) and ( kip1 ) . Negative_regulation CDK9 IFI27 24067984 2867173 Western blot analysis of key cell cycle regulators revealed that K-Rta mediated cell cycle arrest was associated with a decrease in cyclin A and phosphorylated Rb ( pS807/pS811 ) protein levels , both markers of S phase progression , and an increase in protein levels for , a [cyclin dependent kinase] *inhibitor* . Negative_regulation CDK9 IFI27 24708177 2938875 Recently , STMN1 was reported to interact with , an *inhibitor* of [cyclin dependent kinase] complexes . Negative_regulation CDK9 IFI27 8654372 366880 Expression of Zta results in induction of the tumor suppressor protein , p53 , and the [cyclin dependent kinase] *inhibitors* , p21 and , as well as accumulation of hypophosphorylated pRb . Negative_regulation CDK9 IFI27 8845296 337838 We have examined the level of cyclin E , a G1 cyclin , and , a [cyclin dependent kinase] *inhibitor* , in BALB/c 3T3 cells . Negative_regulation CDK9 IFI27 9616167 509586 The identification of ( kip1 ) , a [cyclin dependent kinase] *inhibitor* that contributes to cell cycle arrest and represents a link between extracellular signals and cell cycle , prompted us to study p27 protein in the lymphocytes from 88 patients with B-CLL and 32 patients with other chronic B-lymphoproliferative disorders . Negative_regulation CDK9 IFI27 9746784 533000 The ( kip-1 ) , a [cyclin dependent kinase] *inhibitor* which is important in blocking the cell cycle , was induced more quickly and potently by Ro 25-9716 ( 10 ( -7 ) mol/L , 0 to 5 days ) than by 1,25D3 , suggesting a possible mechanism by which these analogs inhibit proliferation of leukemic growth . Negative_regulation CDK9 IFI27 9891946 558574 Hence , we have determined the cell cycle profile , expressions and activities of the [cyclin dependent kinase] *inhibitors* ( CDKIs ) , p21CIP1 and , during rat ventricular myocyte development . Negative_regulation CDK9 ITGA9 22138449 2536218 Furthermore , effects of p21 , a [cyclin dependent kinase] *inhibitor* , and integrin a9 ( ) were examined . Negative_regulation CDK9 MAP2K6 10597223 573439 p21Cip1/Waf1 [cyclin dependent kinase] inhibitor ( p21 ) is *inducible* by Raf and ( MAPKK ) , but the level of regulation is unknown . Negative_regulation CDK9 MAP2K6 21871886 2491276 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the [cyclin dependent kinase] inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDK9 RARB 21868513 2473727 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Negative_regulation CDK9 TP63 9614940 509532 In order to elucidate the *role* of in the [heterodimer] , chimeric HIV-1/FIV RT heterodimers were constructed and characterized . Negative_regulation CDKN1A CAPN8 11264351 796623 Considered together , these results suggest that the increase in activity observed following HCMV infection *contributes* significantly to the reduction of [p21cip1] levels and the resultant cell cycle progression . Negative_regulation CDKN1A CCND1 10806303 692118 EGCG induced [p21] ( CIP1/WAF1/SDI1 ) , *inhibited* pRB kinase activity , and impaired pRB phosphorylation . Negative_regulation CDKN1A CCND1 11114718 759173 The kinase activities of cyclin D/CDK4 , 6 and cyclin E/CDK2 complexes were only slightly elevated , consistent with the findings that coordinate increases in p21 , and cyclin E *resulted* in an increase in [cyclin/CDK/p21] complexes . Negative_regulation CDKN1A CCND1 11759294 887705 Quercetin treatment , however , resulted in a moderate *increase* in [Cip1/p21] with no change in Kip1/p27 and a decrease in CDK4 and . Negative_regulation CDKN1A CCND1 12727871 1086525 The stabilization of p21 by Ras was accompanied by high levels of p21 associated cyclin D1 and , similarly to Ras , was *sufficient* to inhibit the proteasome mediated [p21] degradation . Negative_regulation CDKN1A CCND1 12727871 1086526 We show that p21 directly binds to the C8alpha subunit of the 20S proteasome complex and that by competing for binding , *inhibits* [p21] degradation by purified 20S complexes in vitro . Negative_regulation CDKN1A CCND1 15475462 1319233 OSI-461 enhanced the G0-G1 arrest caused by acyclic retinoid , and the combination of these agents caused a synergistic decrease in the levels of expression of cyclin D1 protein and mRNA , inhibited promoter activity , decreased the level of hyperphosphorylated forms of the Rb protein , *induced* increased cellular levels of the [p21] ( CIP1 ) protein and mRNA , and stimulated p21 ( CIP1 ) promoter activity . Negative_regulation CDKN1A CCND1 16170570 1500416 At high doses ( > 25 microM ) , SFN dramatically *induces* the expression of [p21] ( CIP1 ) while significantly inhibits the expression of the G ( 1 ) phase cell cycle regulatory genes such as , cyclin A , and c-myc . Negative_regulation CDKN1A CCND1 16365067 1504888 Lycopene *prevented* smoke induced changes in [p21] ( Waf1/Cip1 ) , Bax-1 , cleaved caspase 3 , , and PCNA in a dose dependent fashion . Negative_regulation CDKN1A CCND1 17666821 1776826 PSC dose-dependently *induced* cyclin dependent kinase (CDK) inhibitor [p21] expression , whereas the expression of , cyclin A , CDK4 , CDK2 , and proliferating cell nuclear antigen ( PCNA ) were decreased by treatment with PSC . Negative_regulation CDKN1A CCND1 18697201 1955464 While LTF treatment downregulated expression of and phosphorylation of retinoblastoma protein ( Rb ) , expression of [p21] and p27 in 5-8F NPC cells was *enhanced* . Negative_regulation CDKN1A CCND1 19153211 2079230 In vivo , azacitidine ( 0.8 mg/kg i.p. ) reduced tumor proliferation and induced apoptosis in both xenografts upmodulating the expression of p16INKA , Bax , Bak , [p21/WAF1] , and p27/KIP1 , and *inhibiting* the activation of Akt activity and the expression of , Bcl-2 , and Bcl-XL . Negative_regulation CDKN1A CCND1 19513541 2092469 Western blotting showed that PI-103 induced down-regulation of and E1 and simultaneously *up-regulated* [p21] and p27 , associated with arrest in the G0-G1 phase of the cell cycle . Negative_regulation CDKN1A CCND1 20179194 2215786 Further studies revealed that BME treatment enhanced p53 , [p21] , and pChk1/2 and *inhibited* cyclin B1 and expression , suggesting an additional mechanism involving cell cycle regulation . Negative_regulation CDKN1A CCND1 20642839 2297557 SFN induced the expression of [p21/CIP1] and p27/KIP1 , and *inhibited* the expression of . Negative_regulation CDKN1A CCND1 21695715 2494307 In the cell cycle related proteins , SJSZ glycoprotein ( 50 µg/ml ) significantly *enhances* the expression of p53 , [p21] , and p27 , whereas it suppressed the activity of . Negative_regulation CDKN1A CCND1 21980390 2493073 Resveratrol induced cell cycle arrest by up-regulating the expression of [p21/CIP1] , p27/KIP1 and *inhibiting* the expression of . Negative_regulation CDKN1A CCND1 22191569 2568783 BME treatment enhanced cellular tumor antigen p53 , [cyclin dependent kinase inhibitor 1A] ( also called p21 ) , and cyclic AMP dependent transcription factor-3 levels and *inhibited* , D2 , and D3 , and mitogen activated protein kinase 8 ( also called Janus kinase ) expression , suggesting an additional mechanism involving cell cycle regulation and cell survival . Negative_regulation CDKN1A CCND1 23708661 2926307 IL-6 promoted NPC cell proliferation in a dose- and time dependent manner , accompanied by increasing and Bcl-2 expression and the Stat3 activation , but *inhibiting* Bax and [p21] expression . Negative_regulation CDKN1A CLU 20307318 2244588 Over-expression of secretory also *blocks* the TNFalpha mediated induction of [p21] and abrogates the cleavage of Bax to t-Bax , rendering the MCF-7CLU cells significantly more resistant to the cytokine than the parental cells . Negative_regulation CDKN1A EPHB2 15212949 1262418 Decreasing with the pharmacological inhibitors , PD98059 and U0126 , markedly *suppresses* hyperoxia stimulated phospho-p53 ( Ser15 ) , p53 , and [p21] ( CIP1 ) , and also restores the hyperoxia reduced kinase activities of cyclin D1/E1-Cdks . Negative_regulation CDKN1A EPHB2 20664969 2298212 Immunoblot analysis demonstrated that oridonin treatment increased expression levels of p-JNK , p-p38 , p-p53 and [p21] , elevated the level of cyclin B1/p-Cdc2 ( Tyr15 ) complex , and *inhibited* the expression of . Negative_regulation CDKN1A EPHB2 20855497 2325821 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the [p21] ( Waf1/Cip1 ) cyclin dependent kinase inhibitor , and induction of senescence . Negative_regulation CDKN1A EPHB2 21871886 2491279 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the cyclin dependent kinase inhibitors , p16(INK4A) and [p21] ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDKN1A EPHB2 23772367 2714458 VN attenuated radiation induced expression of [p21] , an inhibitor of cell cycle progression , and selectively *inhibited* and p38 MAPK dependent p21 induction after radiation exposure through regulation of the activity of GSK-3ß . Negative_regulation CDKN1A FAS 14767544 1207628 In SK-Br3 cells , cerulenin induced inhibition of activity *resulted* in down-regulation of p53 , and up-regulation of cyclin dependent kinase inhibitor (CDKi) [p21WAF1/CIP1] . Negative_regulation CDKN1A FAS 15094777 1258186 Moreover , depletion of by RNAi also *caused* loss of ERalpha expression , downregulation of PR , and accumulation of [p21WAF1/CIP1] and p27Kip1 in E2-stimulated Ishikawa cells . Negative_regulation CDKN1A FOXO1 24769335 2939541 CAR mediated repression of transcriptional activity *regulates* the cell cycle inhibitor [p21] in mouse livers . Negative_regulation CDKN1A ID1 23342268 2712717 Moreover , through gene silencing approaches we show that and Id3 primarily *attenuates* [CDKN1A] ( p21 ) and CDKN1B ( p27 ) , respectively . Negative_regulation CDKN1A ID1 9315646 455913 In correlation with the finding that E47 overexpression leads to growth arrest in NIH 3T3 cells , we have shown that overexpression in NIH 3T3 cells accelerates cell growth and *inhibits* [p21] expression . Negative_regulation CDKN1A IFI27 11145574 780302 and 5 ) SMS suppresses mitogen induced ( Kip1 ) down-regulation , as well as marginally *induces* [p21] ( Cip ) expression . Negative_regulation CDKN1A IFI27 12466968 1022423 Collectively , our data suggest that [p21] ( Cip1 ) suppresses tumor formation elicited by multiple agents and that p21 ( Cip1 ) and ( Kip1 ) *suppress* tumor formation in different ways . Negative_regulation CDKN1A IFI27 16400524 1494643 In Western blot analysis , p21 induced cytoplasmic translocation of [Waf1] ( Cip1/p27 ) and> Kip ( p271 ) and phosphorylation of Kip ( p211 ) but rk-2 treatment *inhibited* translocation of ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation CDKN1A IL1B 12171790 974223 *inhibits* expression of [p21] ( WAF1/CIP1 ) and p27 ( KIP1 ) and enhances proliferation in response to platelet derived growth factor-BB in smooth muscle cells . Negative_regulation CDKN1A MAP2K6 10597223 573446 [p21Cip1/Waf1] cyclin dependent kinase inhibitor ( p21 ) is *inducible* by Raf and ( MAPKK ) , but the level of regulation is unknown . Negative_regulation CDKN1A MAP2K6 21871886 2491285 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the cyclin dependent kinase inhibitors , p16(INK4A) and [p21] ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDKN1A TFPI2 9575175 502608 Employing a stable cell line derived from p53-deficient human fibroblast that contains tetracycline regulated transactivator and operator plasmids to control the expression of wild-type p53 ( TR9-7 cells ) , we then show that the induction of [p21] ( WAF1/Cip1 ) , which occurs in *response* to the inhibition of expression , requires the p53 protein . Negative_regulation CDKN1A TNF 14599803 1161373 We found that the histone deacetylase (HDAC) inhibitors ( phenylbutyrate and trichostatin A ) causing histone hyperacetylation to modulate multiple gene expression not only induced the expression of [p21] ( Cip1 ) and p16(INK4) in synovial cells but also *inhibited* the expression of in affected tissues in adjuvant arthritis , an animal model of RA . Negative_regulation CDKN1A TNFSF10 11992615 938777 In addition , combined and wortmannin treatment *resulted* in cleavage of several proteins : PARP , Akt , [p21/WAF1] , and MDM2 as well as dephosphorylation of Akt . Negative_regulation CDKN1A TP63 17018588 1630147 In normal primary human keratinocytes , we find that inhibition of endogenous by RNA interference ( RNAi ) *induces* [p21] ( CIP1 ) expression , inhibits cell cycle progression , and ultimately promotes cellular senescence . Negative_regulation CDKN1B CCND1 9111314 425635 As cdk4- and cdk6 associated p15INK4B increased during TGF-beta arrest of sensitive cells , there was a loss of , p21Cip1 , and p27Kip1 from these kinase complexes , and cyclin E-cdk2 associated [p27Kip1] *increased* . Negative_regulation CDKN1B EPHB2 15930121 1433869 Furthermore , in response to H2O2 , inhibition of activation *repressed* p66shcA dependent phosphorylation of FOXO3a and the down-regulation of its target gene [p27kip1] . Negative_regulation CDKN1B EPHB2 20181064 2215969 High activity *suppresses* expression of the cell cycle inhibitor [p27Kip1] in colorectal cancer cells . Negative_regulation CDKN1B FAS 15094777 1258187 Moreover , depletion of by RNAi also *caused* loss of ERalpha expression , downregulation of PR , and accumulation of p21WAF1/CIP1 and [p27Kip1] in E2-stimulated Ishikawa cells . Negative_regulation CDKN1B FOXO1 12773534 1113403 Reducing expression using RNA interference , on the other hand , *attenuated* [p27Kip1] expression and stimulated endothelial cell proliferation . Negative_regulation CDKN1B FOXO1 12891709 1117759 To understand mechanisms by which IGF-I signals the downregulation of p27Kip1 in rat skeletal satellite cells , the *role* of Forkhead transcription factor in transcriptional activity of [p27Kip1] was examined . Negative_regulation CDKN1B FOXO1 23251696 2709014 is present in quiescent pituitary cells during development and is *increased* in the absence of [p27 Kip1] . Negative_regulation CDKN1B ID1 23342268 2712719 Moreover , through gene silencing approaches we show that and Id3 primarily *attenuates* CDKN1A ( p21 ) and [CDKN1B] ( p27 ) , respectively . Negative_regulation CDKN1B IFI27 10951574 723712 Inhibition of MEK activation completely abrogated OSM and IL-6 *induced* [p27kip1] accumulation , while expression of dominant negative STAT5 decreased the OSM and IL-6 mediated inhibition of DNA-synthesis and partially inhibited accumulation . Negative_regulation CDKN1B IFI27 18583941 1953324 Roles of cyclin dependent kinase *inhibitors* , p21/Cip1 ( p21 ) and [p27/Kip1] ( ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation CDKN1B IFI27 20158095 2208550 The growth inhibition was mediated by a cyclin dependent kinase inhibitor , [p27(Kip1)] , accumulation which is *induced* by both inhibition of ubiquitylation of p27 ( Kip1 ) and reduction of degradation activity of ( Kip1 ) by proteasome . Negative_regulation CDKN1B MAP2K6 10951574 723718 Inhibition of activation completely abrogated OSM and IL-6 *induced* [p27kip1] accumulation , while expression of dominant negative STAT5 decreased the OSM and IL-6 mediated inhibition of DNA-synthesis and partially inhibited p27kip1 accumulation . Negative_regulation CDKN1B MAP2K6 9264403 449307 Inhibition of the activation of mitogen activated protein (MAP) kinase by cyclic AMP elevating agents and a inhibitor *prevented* the oncogenic Ras induced degradation of [p27Kip1] . Negative_regulation CDKN1C CALM3 2952648 71172 decreased the rate of phosphorylation of P-57 by protein kinase C , and phosphorylation *prevented* [P-57] binding to calmodulin-Sepharose . Negative_regulation CDKN1C COPS6 23187808 2707772 These data suggest that CSN6 is an important negative regulator of p57 (Kip2) , and that overexpression of in many types of cancer could *lead* to decreased expression of [p57 (Kip2)] and result in promoted cancer cell growth . Negative_regulation CDKN1C CTCF 21304052 2431445 Transient depletion of by small interfering RNA increased CDKN1C expression and significantly *reduced* the estrogen mediated repression of [CDKN1C] . Negative_regulation CDKN1C CXCL12 22889515 2642366 We also searched the *role* of signal in [p57kip2] expression in vitro . Negative_regulation CDKN1C EZH2 19340297 2056707 In particular , we show that [CDKN1C] is targeted by histone methyltransferase EZH2 mediated histone H3 lysine 27 trimethylation ( H3K27me3 ) , and can be strongly *activated* by inhibition of in synergy with histone deacetylase inhibitor . Negative_regulation CDKN1C FLI1 11423975 831108 The inducible expression of *led* to a strong upregulation of c-Myc and a considerable downregulation of [p57KIP2] . Negative_regulation CDKN1C FLI1 18271016 1911574 In this report , we show that depletion of in Ewing 's cell lines *results* in a senescence phenotype , a marked increase in expression of the G1/S regulatory proteins p27 ( kip1 ) and [p57(kip2)] , and a significant decrease in cyclin D1 and CDK2 . Negative_regulation CDKN1C ID3 21964314 2502757 Further , potently *repressed* expression of the [cyclin dependent kinase inhibitor p57] ( Kip2 ) , a gene which is also silenced in a rare ß-cell hyperproliferative disorder in infants . Negative_regulation CDKN1C IL8 22945845 2715883 Additionally , *suppressed* the major cell cycle inhibitor [CDKN1C/p57] ( KIP2 ) by downregulating its positive regulator PROX1 , which is known as the master regulator of LEC-differentiation . Negative_regulation CDKN1C MIR221 21278784 2398204 *inhibits* [CDKN1C/p57] expression in human colorectal carcinoma . Negative_regulation CDKN1C MIR221 21278784 2398207 binds to the target site in the 3'-UTR of the CDKN1C/p57 mRNA to *inhibit* [CDKN1C/p57] expression by post-transcriptional gene silencing to promote CRC occurrence and progress , therefore serving as a potential therapeutic target for the prevention and treatment of CRC . Negative_regulation CDKN1C MIR221 22126772 2514794 inhibitor significantly *up-regulated* [CDKN1C/p57] protein expression in Caco2 cells ( P < 0.01 ) . Negative_regulation CDKN1C MYLIP 21278784 2398206 Moreover , a inhibitor significantly *increased* [CDKN1C/p57] protein expression in CRC cells . Negative_regulation CDKN1C MYLIP 21538272 2423904 inhibitor significantly *enhanced* [CDKN1C/P57] protein expression , inhibited proliferation of CRC cells and induced apoptosis of CRC cells ( P < 0.01 ) . Negative_regulation CDKN1C NOTCH1 22705236 2633859 In this study , we show that the down-regulation of and Notch3 in two HCC cell lines *resulted* in Hes1 down-regulation , [CDKN1C/P57] up-regulation , and reduced cell growth . Negative_regulation CDKN1C NOTCH1 25005473 2948368 Using several mouse models combined with ex vivo studies , we demonstrate that signaling is *required* to repress p21 ( cip1 ) and [p57(kip2)] expression in muscle progenitor cells . Negative_regulation CDKN1C NOTCH2 25005473 2948369 Using several mouse models combined with ex vivo studies , we demonstrate that signaling is required to *repress* p21 ( cip1 ) and [p57(kip2)] expression in muscle progenitor cells . Negative_regulation CDKN1C NOTCH3 22705236 2633860 In this study , we show that the down-regulation of Notch1 and in two HCC cell lines *resulted* in Hes1 down-regulation , [CDKN1C/P57] up-regulation , and reduced cell growth . Negative_regulation CDKN1C NOTCH3 25005473 2948370 Using several mouse models combined with ex vivo studies , we demonstrate that signaling is *required* to repress p21 ( cip1 ) and [p57(kip2)] expression in muscle progenitor cells . Negative_regulation CDKN1C NOTCH4 25005473 2948371 Using several mouse models combined with ex vivo studies , we demonstrate that signaling is required to *repress* p21 ( cip1 ) and [p57(kip2)] expression in muscle progenitor cells . Negative_regulation CDKN1C PAK4 23873832 2839273 Here , by using quantitative RT-PCR and immunoblot analyses , we discovered that over-expression of could *suppress* [cyclin dependent kinase inhibitor 1C] ( p57(Kip2) ) expression in the MCF-7 human breast cancer cell line , whereas lentiviral vector mediated small interfering RNA ( siRNA ) knockdown of PAK4 markedly promoted p57(Kip2) expression in MCF-7 cells . Negative_regulation CDKN1C PAK4 23873832 2839274 Furthermore , *mediated* down-regulation of [p57(Kip2)] was reversed by MG132 , a specific proteasome inhibitor . Negative_regulation CDKN1C PAK4 23873832 2839275 The ubiquitination assay confirmed that the activity of *attenuated* [p57(Kip2)] protein stability through the ubiquitin-proteasome pathway in MCF-7 cells . Negative_regulation CDKN1C SEC14L2 23470527 2750369 mediated suppression of cell migration *requires* [p57Kip2] control of actin cytoskeleton dynamics . Negative_regulation CDKN1C SKP2 12925736 1135309 Overexpression of WT *promoted* degradation of [p57Kip2] , whereas expression of a dominant negative mutant of Skp2 prolonged the half-life of p57Kip2 . Negative_regulation CDKN1C TGFB1 10708569 673521 We previously uncovered that growth stimulation of rat primary osteoblasts by ( TGF-beta1 ) *resulted* in a dramatic decrease in [p57(Kip2)] , a member of cyclin dependent kinase (CDK) inhibitors , through the proteasomal degradation pathway ( Urano et al. , J. Biol. Chem. 274 , 12197-12200 , 1999 ) . Negative_regulation CDKN2A CCND1 10537346 563219 Loss of [p16INK4A] in the *presence* of overexpression conferred a significantly worse disease-free ( P = 0.011 ) and overall ( P = 0.002 ) survival at 5 years . Negative_regulation CDKN2A EPHB2 15917995 1413221 We have demonstrated that ( MAPK ) signaling was *involved* in the induction of both p15(INK4b)and [p16(INK4a)] CDK inhibitors and growth inhibition of hepatoma cell HepG2 triggered by the tumor promoter tetradecanoyl phorbol acetate ( TPA ) . Negative_regulation CDKN2A EPHB2 21871886 2491288 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the cyclin dependent kinase inhibitors , [p16(INK4A)] and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDKN2A ID1 11507043 848054 These data suggest a *role* for in regulating [p16/Ink4a] expression in early melanomas and demonstrate that later genetic changes may provide for irreversible loss of p16 expression in advanced stages of this tumor . Negative_regulation CDKN2A ID1 12949053 1158036 As p16INK4a protein is inactivated in hepatocellular carcinoma ( HCC ) , we aimed to investigate the *role* of in regulating [p16INK4a] expression during the development of HCC in HCC patients and direct ectopic Id-1 introduction into the PLC/PRF/5 HCC cell line . Negative_regulation CDKN2A ITGAL 9865919 556412 These include myc proto-oncogene , 40S ribosomal protein S19 , heat shock proteins , leukosialin S ( CD43 ) , integrin alphaL ( ) , calgranulin (A) , and CDK4 *inhibitor* ( [p16ink4] ) . Negative_regulation CDKN2A MAP2K6 21871886 2491294 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the cyclin dependent kinase inhibitors , [p16(INK4A)] and p21 ( CIP1 ) , but not Rb phosphorylation and E2F1 expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Negative_regulation CDKN2A TNF 14599803 1161378 We found that the histone deacetylase (HDAC) inhibitors ( phenylbutyrate and trichostatin A ) causing histone hyperacetylation to modulate multiple gene expression not only induced the expression of p21 ( Cip1 ) and [p16(INK4)] in synovial cells but also *inhibited* the expression of in affected tissues in adjuvant arthritis , an animal model of RA . Negative_regulation CDKN2B EPHB2 15917995 1413222 We have demonstrated that ( MAPK ) signaling was *involved* in the induction of both [p15(INK4b)and] p16(INK4a) CDK inhibitors and growth inhibition of hepatoma cell HepG2 triggered by the tumor promoter tetradecanoyl phorbol acetate ( TPA ) . Negative_regulation CDT1 CCND1 18006686 1827333 Nuclear accumulation of during S phase *inhibits* Cul4 dependent [Cdt1] proteolysis and triggers p53 dependent DNA rereplication . Negative_regulation CDX2 TNF 22326557 2586479 *induced* down-regulation of [CDX2] suppresses MEP1A expression in colitis . Negative_regulation CDX2 TNF 22326557 2586500 The present results indicate that a *mediated* down-regulation of [CDX2] can be related to suppressed expression of MEP1A during intestinal inflammation . Negative_regulation CDX2 TNF 24501326 2933211 The aim was to investigate the signaling pathways involved in the *mediated* downregulation of [CDX2] , and its influence on Wnt/ß-catenin signaling components in colon cancer cells . Negative_regulation CDX2 TNF 24501326 2933212 Inhibition of nuclear factor-kappaB or p38 pathways showed that these are involved in the *dependent* downregulation of [CDX2] . Negative_regulation CDX2 TNF 24501326 2933214 Furthermore , *mediated* downregulation of [CDX2] was found to significantly decrease the mRNA levels of adenomatous polyposis coli (APC) , axis inhibition protein 2 (AXIN2) and glycogen synthase kinase-3 beta ( GSK3ß ) , whereas the mRNA levels of Wnt targets were significantly elevated in TNF-a treated Caco-2 cells . Negative_regulation CEACAM1 TNF 2019266 157118 The *inhibition* of [BGP] secretion was independent of changes in [ 14C ] leucine incorporation , suggesting that TNF alpha did not have a general inhibitory effect on total protein synthesis . Negative_regulation CEACAM5 ARSA 12423325 1014164 Production of [carcinoembryonic antigen] and the invasive potential of SW480 cells were also *inhibited* by . Negative_regulation CEACAM6 CCL2 10229865 611189 [NCA] was *inhibited* by leukotriene B4 receptor antagonist and anti-IL-8 and G-CSF Abs. MCA was attenuated by leukotriene B4 receptor antagonist , and , GM-CSF , and TGF-beta Abs . Leukotriene B4 receptor antagonist and these Abs inhibited the corresponding m.w . Negative_regulation CEACAM6 CSF2 10229865 611190 [NCA] was *inhibited* by leukotriene B4 receptor antagonist and anti-IL-8 and G-CSF Abs. MCA was attenuated by leukotriene B4 receptor antagonist , and monocyte chemoattractant protein-1 , , and TGF-beta Abs . Leukotriene B4 receptor antagonist and these Abs inhibited the corresponding m.w . Negative_regulation CEACAM6 SOX9 19637360 2182905 Defect in [CEACAM] family member expression in Crohn 's disease IECs is *regulated* by the . Negative_regulation CEBPA IL1B 16865359 1592775 Down-regulation of peroxisome proliferating activated receptor gamma and [CCAAT/enhancer binding protein alpha] in *response* to may have contributed to the altered phenotype of IL1B treated adipocytes . Negative_regulation CEBPA TNF 1618860 191385 Transcriptional *repression* of the [C/EBP-alpha] and GLUT4 genes in 3T3-L1 adipocytes by . Negative_regulation CEBPA TNF 1939208 170405 Transcriptional *repression* of the GLUT4 and [C/EBP] genes in 3T3-L1 adipocytes by . Negative_regulation CEBPA TNF 7956951 277899 Treatment of 3T3-L1 cells with troglitazone ( 1-10 microM ) partially prevented this inhibitory effect of TNF on adipogenesis , and enhanced expression of [C/EBP alpha] and GLUT4 , even in the *presence* of . Negative_regulation CEBPB EPHB2 19276382 2046266 Ras ( V12 ) -induced silencing of [C/EBPbeta] occurred at the mRNA level and *involved* both the Raf-mitogen activated protein/extracellular signal regulated kinase ( ERK ) and phosphatidylinositol 3-kinase signaling pathways . Negative_regulation CEBPB TNF 11820362 908776 Transfection of NFkappaB and C/EBPbeta-sensitive reporter promoter constructs demonstrated that NFkappaB activity was enhanced and that constitutive [C/EBPbeta] was *inhibited* by , with both effects being p38 MAPK dependent . Negative_regulation CEBPB TNF 12871593 1114134 *Activation* of NF-kappaB as well as [C/EBPbeta] by p40 and inhibition of p40 induced expression of by Deltap65 , a dominant negative mutant of p65 , and DeltaC/EBPbeta , a dominant negative mutant of C/EBPbeta , suggests that p40 induces the expression of TNF-alpha through the activation of NF-kappaB and C/EBPbeta . Negative_regulation CENPA TNF 22025632 2508067 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation CENPE TNF 22025632 2508068 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation CENPF TNF 22025632 2508069 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation CERS1 CD14 7686144 219828 Moreover , after exposure of the cells to fumonisin B1 , an *inhibitor* of [ceramide synthase] , , even in the wild type cells , became hypersensitive to PI-PLC . Negative_regulation CERS2 CD14 7686144 219827 Moreover , after exposure of the cells to fumonisin B1 , an *inhibitor* of [ceramide synthase] , , even in the wild type cells , became hypersensitive to PI-PLC . Negative_regulation CERS3 CD14 7686144 219831 Moreover , after exposure of the cells to fumonisin B1 , an *inhibitor* of [ceramide synthase] , , even in the wild type cells , became hypersensitive to PI-PLC . Negative_regulation CERS4 CD14 7686144 219829 Moreover , after exposure of the cells to fumonisin B1 , an *inhibitor* of [ceramide synthase] , , even in the wild type cells , became hypersensitive to PI-PLC . Negative_regulation CERS5 CD14 7686144 219830 Moreover , after exposure of the cells to fumonisin B1 , an *inhibitor* of [ceramide synthase] , , even in the wild type cells , became hypersensitive to PI-PLC . Negative_regulation CERS6 CD14 7686144 219832 Moreover , after exposure of the cells to fumonisin B1 , an *inhibitor* of [ceramide synthase] , , even in the wild type cells , became hypersensitive to PI-PLC . Negative_regulation CFI KRT76 2147856 145504 Treatment with , an *inhibitor* of [C3bINA] ( I factor ) , resulted in a marked inhibition of phagosome-lysosome fusion in S. typhi infected macrophages , although no significant inhibition was observed on phagocytosis of S. typhi . Negative_regulation CFL1 CAPN8 18765479 1985668 Mutagenesis studies indicated that cleavage of WAVE1 by *results* in the removal of the verprolin-homology , [cofilin-like] , and acidic domain and thus , the loss of WAVE1 activity . Negative_regulation CFL1 MAP2K6 14559914 1186131 Inhibition of in Ras transformed NIH3T3 results in restoration of actin stress fibers accompanied by a loss of cytoplasmic p21(Cip1) , and *increased* phosphorylation of [cofilin] . Negative_regulation CFL2 CAPN8 18765479 1985682 Mutagenesis studies indicated that cleavage of WAVE1 by *results* in the removal of the verprolin-homology , [cofilin-like] , and acidic domain and thus , the loss of WAVE1 activity . Negative_regulation CFL2 MAP2K6 14559914 1186138 Inhibition of in Ras transformed NIH3T3 results in restoration of actin stress fibers accompanied by a loss of cytoplasmic p21(Cip1) , and *increased* phosphorylation of [cofilin] . Negative_regulation CFLAR TNFSF10 20663232 2305182 In addition , *induced* down-regulation of DNA-PKcs/Akt/GSK-3beta pathway and [c-FLIP] and up-regulation of cell surface expression of death receptors were associated with the increased susceptibility to TRAIL of MDR cells . Negative_regulation CFP IL1B 8560198 348978 anti-IL-1 alpha , <-IL-1 beta> , -IL-4 , -IFN gamma and -IL-13 *suppressed* [PFC] induction . Negative_regulation CFP TCN1 3159691 48953 given before a primary immunization *suppressed* a secondary [PFC] response to SRBC elicited 28 days later . Negative_regulation CFTR ANO1 22178883 2518398 On the other hand , [CFTR-currents] were *attenuated* by additional expression of . Negative_regulation CFTR CAPN8 21111762 2372160 Inhibition of intracellular activity prevents CFTR degradation and *leads* to a 10-fold increase in the level of [F508del-CFTR] at the plasma membrane , further indicating the involvement of calpain activity in the maintenance of very low levels of mature channel form . Negative_regulation CFTR TNF 7526699 280475 IFN-gamma and synergistically *reduce* [CFTR] gene expression . Negative_regulation CGA FOXO1 22865884 2677412 We also showed that *repressed* basal transcription and [gonadotropin releasing hormone (GnRH)] induction of both the murine and human LHB genes in LßT2 cells , suggesting that FOXO1 regulation of LHB transcription may be conserved between rodents and humans . Negative_regulation CGA GPR115 16293662 1518605 The action of GnIH on the inhibition of [gonadotropin] release is *mediated* by a novel in the quail pituitary . Negative_regulation CGA GPR132 16293662 1518594 The action of GnIH on the inhibition of [gonadotropin] release is *mediated* by a novel in the quail pituitary . Negative_regulation CGA GPR87 16293662 1518674 The action of GnIH on the inhibition of [gonadotropin] release is *mediated* by a novel in the quail pituitary . Negative_regulation CGA PLAT 16514196 1530776 The results suggest that [gonadotropin] surge *induced* regulation of tissue inhibitor of metalloproteinase-4 and may be prostanoid dependent , and support a potential role for increased tissue plasminogen activator expression and decreased tissue inhibitor of metalloproteinase-4 expression in the mechanism of ovulation . Negative_regulation CGA TNF 1727811 180929 *inhibits* human chorionic [gonadotropin] secretion . Negative_regulation CGB8 FOXO1 22865884 2677411 We also showed that *repressed* basal transcription and [gonadotropin releasing hormone (GnRH)] induction of both the murine and human LHB genes in LßT2 cells , suggesting that FOXO1 regulation of LHB transcription may be conserved between rodents and humans . Negative_regulation CGB8 GPR115 16293662 1518512 The action of GnIH on the inhibition of [gonadotropin] release is *mediated* by a novel in the quail pituitary . Negative_regulation CGB8 GPR132 16293662 1518501 The action of GnIH on the inhibition of [gonadotropin] release is *mediated* by a novel in the quail pituitary . Negative_regulation CGB8 GPR87 16293662 1518581 The action of GnIH on the inhibition of [gonadotropin] release is *mediated* by a novel in the quail pituitary . Negative_regulation CGB8 PLAT 16514196 1530775 The results suggest that [gonadotropin] surge *induced* regulation of tissue inhibitor of metalloproteinase-4 and may be prostanoid dependent , and support a potential role for increased tissue plasminogen activator expression and decreased tissue inhibitor of metalloproteinase-4 expression in the mechanism of ovulation . Negative_regulation CGB8 TNF 1727811 180928 *inhibits* human chorionic [gonadotropin] secretion . Negative_regulation CHEK1 GNE 24038068 2862631 Here we report that , a novel [checkpoint kinase-1 (CHK1)] *inhibitor* , enhances the activity of gemcitabine by disabling the S- and G2 cell-cycle checkpoints following DNA damage . Negative_regulation CHGA MSX1 19262020 2100199 Transfection assay demonstrated that markedly *repressed* the basal [Cga] and Fshb gene expression , while Lhb expression was affected slightly . Negative_regulation CHGA TLR7 21376231 2400213 We demonstrate that signaling enhances the rate of acidification of the Salmonella containing phagosome , and inhibition of this acidification *prevents* [SPI-2] induction . Negative_regulation CHGA TNF 16574984 1568537 *attenuated* JAK2/STAT5 and ERK1/2 phosphorylation and IGF-I and [Spi] 2.1 mRNA expression following GH stimulation . Negative_regulation CHGA TNF 16574984 1568545 *prevented* the induction of [Spi] 2.1 promoter activity by GH and the STAT5 construct . Negative_regulation CHGA TNF 18719026 1984924 The 5- to 6-fold induction of [Spi] 2.1 and IGF-I promoter activity by GH was *inhibited* by . Negative_regulation CHGA TNF 21462331 2412862 This study also showed that tumor necrosis factor a (TNF-a) induced [SPI-3] mRNA expression in HT-29 human colon cancer cells , and vitamin B6 ( pyridoxal hydrochloride ) pretreatment of HT-29 cells *inhibited* -induced mRNA expression of SPI-3 . Negative_regulation CHI3L1 CD80 7533092 292208 The antigen induced expression of [gp39] on transgenic T cells was *inhibited* by antibodies to class II major histocompatibility complex , CD4 and LFA-1 , but not by CTLA-4 Ig , or anti-B7-2 . Negative_regulation CHI3L1 CD86 7533092 292209 The antigen induced expression of [gp39] on transgenic T cells was *inhibited* by antibodies to class II major histocompatibility complex , CD4 and LFA-1 , but not by CTLA-4 Ig , anti-B7-1 or . Negative_regulation CHI3L1 FGF2 15771622 1384458 In contrast , both and tumor necrosing factor-alpha *repressed* [YKL-40] . Negative_regulation CHI3L1 IFNG 8103067 226020 Expression of [gp39] was *inhibited* by on activated Th1 , Th2 , and CD4+ T cells ; Negative_regulation CHI3L1 IL1B 11315922 806430 , but not TGFbeta , *reduced* [YKL-40] production in cartilage explant cultures . Negative_regulation CHI3L1 IL6 21478032 2434030 To study the possible *role* of and tumor necrosis factor (TNF)-a in the regulation of [YKL-40] plasma levels , we included healthy men , who received either recombinant human ( rh ) IL-6 ( n=6 ) , rhTNF-a ( n=8 ) or vehicle ( n=7 ) for 3h . Negative_regulation CHI3L1 MMP1 12195629 981716 The measured biochemical markers included , MMP-3 , and MMP-13 , the tissue *inhibitor* of MMPs ( TIMP-1 ) , COMP , [YKL-40] , and tenascin . Negative_regulation CHI3L1 MMP13 12195629 981717 The measured biochemical markers included MMP-1 , MMP-3 , and , the tissue *inhibitor* of MMPs ( TIMP-1 ) , COMP , [YKL-40] , and tenascin . Negative_regulation CHI3L1 MMP3 12195629 981718 The measured biochemical markers included MMP-1 , , and MMP-13 , the tissue *inhibitor* of MMPs ( TIMP-1 ) , COMP , [YKL-40] , and tenascin . Negative_regulation CHI3L1 NFKB1 18708058 1961526 Selective *repression* of [YKL-40] by in glioma cell lines involves recruitment of histone deacetylase-1 and -2 . Negative_regulation CHI3L1 RELA 18708058 1961527 Selective *repression* of [YKL-40] by in glioma cell lines involves recruitment of histone deacetylase-1 and -2 . Negative_regulation CHI3L1 SCGB1A1 20093645 2241891 Furthermore , nasal mucosal gene transfer in CC10-knockout mice attenuated eosinophilic inflammation and *suppressed* the levels of [CHI3L1] . Negative_regulation CHI3L1 TIMP1 23663694 2784956 Enzyme linked immunosorbent assay ( ELISA ) was employed to measure levels of five serum proteins previously demonstrated to be up-regulated in papillary thyroid cancer (PTC) : angiopoietin-1 (Ang-1) , cytokeratin 19 (CK-19) , tissue *inhibitor* of metalloproteinase-1 ( ) , [chitinase 3 like-1] ( YKL-40 ) , and galectin-3 (GAL-3) . Negative_regulation CHI3L1 TNF 21478032 2434029 To study the possible *role* of interleukin-6 (IL-6) and in the regulation of [YKL-40] plasma levels , we included healthy men , who received either recombinant human ( rh ) IL-6 ( n=6 ) , rhTNF-a ( n=8 ) or vehicle ( n=7 ) for 3h . Negative_regulation CHI3L1 TP53 15771622 1384457 Inhibition of *augmented* the [YKL-40] expression indicating that YKL-40 is attenuated by p53 . Negative_regulation CHKA TFPI2 21921034 2506883 A comparable *role* for in the regulation of [Chk1] phosphorylation was also observed in human cells . Negative_regulation CHRD PCSK9 19063703 2018002 Annexin A2 specifically binds the [CHRD] and *inhibits* function , and Annexin A2 peptide mimics could pave the way for the development of novel PCSK9-inhibitory compounds . Negative_regulation CHUK ARSA 10593965 572931 Recombinant [IKKalpha] and IKKbeta autophosphorylation and their phosphorylation of glutathione S-transferase-IkappaBalpha are *inhibited* by <5-ASA> . Negative_regulation CHUK ARSA 10593965 572933 However , [IKKalpha] serine phosphorylation by its upstream kinase in either intact cells or cellular extracts is not *blocked* by <5-ASA> . Negative_regulation CHUK EGLN3 23732909 2811908 Instead , interaction with IKK? is required for the ability of to *inhibit* IKK? ubiquitination and [IKK-NF-?B] signaling . Negative_regulation CHUK EPHB2 14604964 1209542 The antigen induced tyrosine phosphorylation of FcepsilonRI , Syk , phospholipase C-gamma (PLC-gamma) , activation of c-Jun N-terminal kinase (JNK) , extracellular signal regulated kinase ( ) , *inhibitor* of nuclear factor kappaB kinase ( [IKK] ) , and Ca++ influx were all suppressed in the cells overexpressing Cbl-b in the lipid raft . Negative_regulation CHUK EPHB2 16242916 1532014 Consistently , inhibition of significantly *increased* [IkappaB kinase (IKK)] activity , IkappaBalpha phosphorylation , and nuclear translocation of NF-kappaB induced by VEGF , whereas overexpression of ERK resulted in the loss of these responses to VEGF . Negative_regulation CHUK FAS 20212524 2223112 We validated experimentally that stimulation *resulted* in an interaction of p43-FLIP with the [IKK complex] followed by its activation . Negative_regulation CHUK TLR7 22037600 2508142 signaling *activates* the inhibitor of transcription factor NF-?B ( I?B ) kinase ( [IKK) complex] , which governs NF-?B mediated transcription during inflammation . Negative_regulation CHUK TLR7 24251781 2903556 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , PI3K/AkT inhibition , [IKK/JNK] *inhibition* , mTORC1 inhibition , JAK/STAT inhibition , suppression , and ACE inhibition . Negative_regulation CHUK TNF 16774932 1672072 PMA selectively causes the degradation of IkappaB kinases ( IKKs ) including IKK-gamma and IKK-beta , and subsequent inhibition of *induced* [IKK] and NF-kappaB activation in human colon cancer cell line HCT-116 , but not in other gastrointestinal tract cells . Negative_regulation CHUK TNF 18346759 1892209 We demonstrated that stimulates IkappaB-alpha phosphorylation through induction of IKK activity , and that fenofibrate *inhibits* [IKK] activity and TNFalpha induced IkappaB-alpha phosphorylation . Negative_regulation CHUK TNF 24215713 2897254 Moreover , classical NF-?B activation ( both by and IKK-ß over-expression ) *reduced* [IKK-a] levels and IKK-a over-expression prevented TNF-a induced impairments in muscle OXPHEN . Negative_regulation CHUK TNF 24215713 2897257 *induced* reductions in muscle [IKK-a] may accelerate muscle OXPHEN deterioration in COPD . Negative_regulation CHUK TNFSF10 17237443 1690118 These results present the combination of stimulation and [IkappaB kinase] *inhibition* as a new approach to MCL therapy . Negative_regulation CIB1 CCND1 19153211 2079220 In vivo , azacitidine ( 0.8 mg/kg i.p. ) reduced tumor proliferation and induced apoptosis in both xenografts upmodulating the expression of p16INKA , Bax , Bak , p21/WAF1 , and [p27/KIP1] , and *inhibiting* the activation of Akt activity and the expression of , Bcl-2 , and Bcl-XL . Negative_regulation CIB1 CCND1 20642839 2297556 SFN induced the expression of p21/CIP1 and [p27/KIP1] , and *inhibited* the expression of . Negative_regulation CIB1 CDKN1C 17050328 1636109 , a [KIP] family cyclin dependent kinase (Cdk) *inhibitor* , blocks the cell cycle by acting on multiple cyclin-Cdk complexes . Negative_regulation CIB1 FOXO1 17015685 1629784 Consistent with the important *role* of in p27 [kip1] transcription , stimulated Vav1 ( -/- ) T cells failed to down-regulate the expression of p27 kip1 , explaining their G0-G1 arrest . Negative_regulation CIB1 FOXO1 21179458 2358274 The inhibition of PI3K/AKT pathway *induced* transcriptional activity resulting in induction of Bim , TRAIL , [p27/KIP1] , DR4 and DR5 , and inhibition of cyclin D1 . Negative_regulation CIB1 IFI27 16020508 1465800 Tregs were blocked from cell cycle progression due to decrease of cyclin E and cyclin A and increase of ( [p27kip] cyclin dependent kinase *inhibitor* ) . Negative_regulation CIB1 IFI27 16869759 1496863 Cdk2 is also dispensable for cell cycle inhibition and tumor suppression by the Cip/Kip *inhibitors* , p21 ( Cip1 ) and ( [Kip1] ) . Negative_regulation CIB1 JAG1 24497510 2913751 In particular , directly *repressed* [KIP RELATED PROTEIN 4 (KRP4)] and KRP2 , which control the transition to the DNA synthesis phase ( S-phase ) of the cell cycle . Negative_regulation CIC EPHB2 23733957 2801903 A recent study established that active *reduces* the nuclear levels of [Cic] , but it remained unclear whether this is required for the induction of Cic target genes . Negative_regulation CIITA IL1B 9916712 587499 *suppressed* IFN-gamma activation of the type IV [CIITA] promoter in astroglioma cells , indicating that the inhibitory influence of IL-1beta is mediated by inhibition of CIITA transcription . Negative_regulation CIITA TNF 10415044 631167 We show here that *suppresses* IFN-gamma induced [CIITA] mRNA accumulation , resulting in decreased MHC class II expression in human fibrosarcoma HT1080 cells . Negative_regulation CIITA TNF 10415044 631169 also *inhibits* [CIITA] mRNA accumulation and protein expression in a tetracycline regulated system without affecting promoter activity . Negative_regulation CIITA TNF 10415044 631172 Consistent with this interpretation , *blocked* IFN-gamma induced [CIITA] and MHC class II expression in mutant cells that are unresponsive to TGF-beta or IFN-beta . Negative_regulation CIRBP TNF 24337574 2905286 Here , we show that and TGFß *impair* the expression of [Cirbp] in fibroblasts and neuronal cells . Negative_regulation CISH ABCA4 23144455 2710777 The results suggest a possible *role* of and , in particular , the NBD1 domain in [11-cis-retinal] binding . Negative_regulation CISH CCND1 14587026 1159651 In both cell lines ATRA and [9-cis] RA *induced* the most profound decreases in and cdk2 expression and also mediated the largest growth inhibition . Negative_regulation CKAP4 FOXO1 23906066 2822508 Insulin/IGF-1 controls epidermal morphogenesis via regulation of mediated [p63] *inhibition* . Negative_regulation CKAP4 TP63 15922574 1440363 [p63] is the identity switch for uterine/vaginal epithelial cell fate , and disruption of expression by diethylstilbestrol (DES) *induces* cervical/vaginal adenosis in mice . Negative_regulation CKAP4 TP63 21820419 2490435 Therefore , we propose a potential biological *role* of interaction in regulation of [p63] during epidermal differentiation . Negative_regulation CKAP5 TNF 22025632 2508076 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation CLASP1 TNF 22025632 2508063 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation CLASP2 TNF 22025632 2508062 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation CLCA1 MUC16 18596559 1953698 Our goal was to investigate the effect of glucocorticosteroids , acetyl-cysteine (ACC) , and calcium activated [chloride channel (CLCA)] inhibitors in a model of Th2 type cytokine *induced* expression in human airway mucosa . Negative_regulation CLCA2 MUC16 18596559 1953713 Our goal was to investigate the effect of glucocorticosteroids , acetyl-cysteine (ACC) , and calcium activated [chloride channel (CLCA)] inhibitors in a model of Th2 type cytokine *induced* expression in human airway mucosa . Negative_regulation CLCA4 MUC16 18596559 1953728 Our goal was to investigate the effect of glucocorticosteroids , acetyl-cysteine (ACC) , and calcium activated [chloride channel (CLCA)] inhibitors in a model of Th2 type cytokine *induced* expression in human airway mucosa . Negative_regulation CLDN1 TNF 23538493 2788578 In addition , *induced* a downregulation of [claudin-1] , claudin-2 , claudin-4 , and occludin as well as activation of phosphatidylinositol 3-kinase signaling in T-84 but not Caco-2 cells , which was reversed by adalimumab . Negative_regulation CLDN4 EPHB2 20593014 2285918 Inhibition of , not JNK , significantly *increased* TER and expression of [claudin 4] in 2CLP monolayers , and prevented significant differences in claudin 18 expression between 2CLP and sham monolayers . Negative_regulation CLDN4 EPHB2 20824291 2341840 Inhibition of signaling *mediated* up-regulation of E-cadherin and [claudin-4] , and/or decreased expression of matrix metalloproteinases ( MMPs ) such as MMP-2 and MMP-9 , play a role in the TZD induced inhibition of cancer cell invasion . Negative_regulation CLDN4 MAP2K6 20824291 2341846 Inhibition of signaling *mediated* up-regulation of E-cadherin and [claudin-4] , and/or decreased expression of matrix metalloproteinases ( MMPs ) such as MMP-2 and MMP-9 , play a role in the TZD induced inhibition of cancer cell invasion . Negative_regulation CLDN4 TNF 23538493 2788579 In addition , *induced* a downregulation of claudin-1 , claudin-2 , [claudin-4] , and occludin as well as activation of phosphatidylinositol 3-kinase signaling in T-84 but not Caco-2 cells , which was reversed by adalimumab . Negative_regulation CLDN5 FOXO1 24280217 2898645 Down-regulation of using siRNA by itself *caused* up-regulation of [claudin-5] expression and partial protection from cytotoxicity . Negative_regulation CLDN5 MMP28 21717368 2447253 *mediated* disruption of [claudin-5] in the blood-brain barrier of rat brain after cerebral ischemia . Negative_regulation CLDN5 MMP7 21717368 2447268 *mediated* disruption of [claudin-5] in the blood-brain barrier of rat brain after cerebral ischemia . Negative_regulation CLDN5 PLAT 24045404 2888218 Progesterone treatment significantly prevented *induced* decrease in TEER and expression of occludin and [claudin-5] , and attenuated VEGF levels in culture media subjected to hypoxia . Negative_regulation CLDN5 TNF 18996436 2016025 significantly *reduced* the promoter activity and mRNA levels of [claudin-5] in brain cEND and myocardial MyEND endothelial cells . Negative_regulation CLDN5 TNF 19333725 2106209 were increased , but [claudin5] were *reduced* in vehicle treated rats after pMCAO . Negative_regulation CLDN7 TNF 22073304 2504449 Cytokines as , IL-6 , and IFN-? *increased* apoptosis and monolayer permeability , inhibited the wound healing and the claudin-3 , [claudin-7] and claudin-8 expression in HT-29/B6 cells . Negative_regulation CLDN8 TNF 22073304 2504451 Cytokines as , IL-6 , and IFN-? *increased* apoptosis and monolayer permeability , inhibited the wound healing and the claudin-3 , claudin-7 and [claudin-8] expression in HT-29/B6 cells . Negative_regulation CLEC4A TNF 11994513 939109 The surface expression of the [CLECSF6] protein was *reduced* by , IL-1alpha , LPS , and Matrigel . Negative_regulation CLIP1 TLR7 20631258 2321916 mediated B cell activation *results* in ectopic [CLIP] expression that promotes B cell dependent inflammation . Negative_regulation CLIP1 TNF 22025632 2508058 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation CLIP2 TLR7 20631258 2321936 mediated B cell activation *results* in ectopic [CLIP] expression that promotes B cell dependent inflammation . Negative_regulation CLIP3 TLR7 20631258 2321926 mediated B cell activation *results* in ectopic [CLIP] expression that promotes B cell dependent inflammation . Negative_regulation CLIP4 TLR7 20631258 2321946 mediated B cell activation *results* in ectopic [CLIP] expression that promotes B cell dependent inflammation . Negative_regulation CLSTN1 EPHB2 21385839 2404447 We also demonstrate that inhibition of *promotes* binding of [calsyntenin-1] to KLC1 . Negative_regulation CLTA MAP2K6 24138302 2868017 The most prominent example of this shift is the management of metastatic melanoma , where BRAF and *inhibition* and [CLTA-4] blockade have established an entirely new standard of care in the last 3 years . Negative_regulation CLU ADAM17 16213748 1501090 Among these 30 genes we found a high proportion of genes associated with apoptotic cell death , cell proliferation and cell cycle signalling including complement lysis *inhibitor* ( [clusterin/CLU] ) , beta-catenin interacting protein ( ICAT ) , peroxisome proliferator activated receptor alpha ( PPARalpha ) , ( ADAM17/TACE ) , homeo box A3 ( HOX1 ) , inositol polyphosphatase 5-phosphatase type IV ( PPI5PIV ) and inhibitor of p53 induced apoptosis alpha ( IPIA-Alpha/NM23-H6 ) . Negative_regulation CLU ANG 10712283 673994 In contrast , clusterin expression was stimulated via AT(2) receptors , a response differing from that in the adult , in which *inhibits* [clusterin] expression via AT(1) receptors . Negative_regulation CLU ANGPT2 7611452 312167 Through AT1 receptors , endogenous stimulates EGF and *inhibits* [clusterin] expression . Negative_regulation CLU DES 8170836 255212 and castration *reduced* prostate weights to 20 % and 6 % of control , respectively , while inducing [TRPM-2] expression to a maximum on day 5 of the experiment . Negative_regulation CLU EGF 10492250 646572 However , *reduced* tubular vimentin by 36 % and [clusterin] expression by 70 % ( markers of tubular injury ) , and decreased tubular atrophy by 50 % in the postobstructed kidney compared with saline treated rats . Negative_regulation CLU EGF 9367891 463448 Results demonstrate that *inhibits* expression of WDNM1 and [SGP-2] genes in mammary epithelial cells . Negative_regulation CLU EGF 9854140 555013 However , strongly *inhibited* the expression of WDNM1 and [SGP-2] genes . Negative_regulation CLU F11 24126506 2853258 Various studies have evaluated the *role* of in DF and [CLI] that resulted favourable in terms of feasibility , technical efficacy , the reduced number of complications , and limb salvage rates . Negative_regulation CLU FDFT1 15037817 1224059 slightly decreased [ Cl-]i in non-hypoxic myocytes and *delayed* the hypoxia/reoxygenation induced increase in [ [Cl-]i] during ischemia and reperfusion ( P < 0.05 ) . Negative_regulation CLU FOS 10406964 629680 The results suggest that the *represses* [clusterin] gene expression , maintaining a low basal level in the absence of TGFbeta , and that TGFbeta , presumably through its effects on c-Fos protein synthesis and/or stability , abrogates the repression of c-Fos , thereby resulting in gene expression . Negative_regulation CLU FOXL2 23051594 2702840 binds and suppresses the PTTG promoter , and [Clu] also *suppresses* PTTG expression , thus neutralizing protumorigenic PTTG gonadotroph tumor cell properties . Negative_regulation CLU HDAC1 20307625 2244618 We have observed earlier that inhibitors can *induce* the expression of [clusterin] in several neuroblastoma and glioma cell lines . Negative_regulation CLU HDAC1 20307625 2244626 Another clinically used inhibitor , the cancer drug , Vorinostat ( SAHA , suberoylanilide hydroxamic acid ) , also robustly *stimulated* the expression of [clusterin] in human astrocytes . Negative_regulation CLU HDAC2 20307625 2244619 We have observed earlier that inhibitors can *induce* the expression of [clusterin] in several neuroblastoma and glioma cell lines . Negative_regulation CLU HDAC2 20307625 2244627 Another clinically used inhibitor , the cancer drug , Vorinostat ( SAHA , suberoylanilide hydroxamic acid ) , also robustly *stimulated* the expression of [clusterin] in human astrocytes . Negative_regulation CLU HIF1A 16414399 1514460 However , little is known about the endogenous angiogenic response and the *role* of in human [critical limb ischemia (CLI)] . Negative_regulation CLU HOXA3 16213748 1501091 Among these 30 genes we found a high proportion of genes associated with apoptotic cell death , cell proliferation and cell cycle signalling including complement lysis *inhibitor* ( [clusterin/CLU] ) , beta-catenin interacting protein ( ICAT ) , peroxisome proliferator activated receptor alpha ( PPARalpha ) , TNF alpha converting enzyme ( ADAM17/TACE ) , ( HOX1 ) , inositol polyphosphatase 5-phosphatase type IV ( PPI5PIV ) and inhibitor of p53 induced apoptosis alpha ( IPIA-Alpha/NM23-H6 ) . Negative_regulation CLU HRAS 16568090 1598087 Oncogenic *suppresses* [clusterin] expression through promoter hypermethylation . Negative_regulation CLU IL24 21732348 2538863 Here , we identify clusterin (CLU) as a MDA-7/IL-24 interacting protein in DU-145 cells and investigate the *role* of in regulating [CLU] expression and mediating the antitumor properties of mda-7/IL-24 in prostate cancer . Negative_regulation CLU LEPR 23673647 2785260 Furthermore , long-form deficiency or hypothalamic low-density lipoprotein receptor related protein-2 suppression in mice *leads* to impaired hypothalamic [clusterin] signalling and actions . Negative_regulation CLU LRP2 10670527 666639 The present data also reveal that after efferent duct ligation , there are circulating factors that inhibit [Apo J] expression in a region-specific manner ( corpus and cauda ) and that *inhibit* expression along the entire epididymis and that these are derived from the testis . Negative_regulation CLU MYCN 23362253 2758739 Here , we show that *inhibits* the expression of [CLU] by direct interaction with the non-canonical E box sequence CACGCG in the 5'-flanking region . Negative_regulation CLU MYLIP 23436804 2803742 The repression of also influences cell death upon DNA damage and *mediates* regulation of NCOA3 ( SRC-3 ) and [CLU] in colon cancer cells . Negative_regulation CLU NA 10533675 562414 In contrast , the glutathione precursor *prevented* PDTC dependent increase in GSSG/GSH ratio , inhibition of SP-A and -B mRNAs , and induction of [apoJ] . Negative_regulation CLU NFKB1 12882985 1142755 Ectopic [apolipoprotein J] expression strongly *inhibited* activity in human neuroblastoma cells and murine embryonic fibroblasts by stabilizing inhibitors of NF-kappaB ( IkappaBs ) . Negative_regulation CLU PTGS1 15331142 1290921 Not only ibuprofen , aspirin ( 100 microM ) , indomethacin ( 50 microM ) , and selective or COX-2 inhibitor ( 10 nM ketrolac or 2 microM NS398 ) also *blocked* the Abeta induced increase in neuronal [ [Cl-]i] , though such effects of COX-2 preferring drugs were limited in aggregated Abeta induced changes . Negative_regulation CLU RBBP4 20307625 2244620 We have observed earlier that inhibitors can *induce* the expression of [clusterin] in several neuroblastoma and glioma cell lines . Negative_regulation CLU RBBP4 20307625 2244628 Another clinically used inhibitor , the cancer drug , Vorinostat ( SAHA , suberoylanilide hydroxamic acid ) , also robustly *stimulated* the expression of [clusterin] in human astrocytes . Negative_regulation CLU RBBP7 20307625 2244621 We have observed earlier that inhibitors can *induce* the expression of [clusterin] in several neuroblastoma and glioma cell lines . Negative_regulation CLU RBBP7 20307625 2244629 Another clinically used inhibitor , the cancer drug , Vorinostat ( SAHA , suberoylanilide hydroxamic acid ) , also robustly *stimulated* the expression of [clusterin] in human astrocytes . Negative_regulation CLU RELA 12882985 1142756 Ectopic [apolipoprotein J] expression strongly *inhibited* activity in human neuroblastoma cells and murine embryonic fibroblasts by stabilizing inhibitors of NF-kappaB ( IkappaBs ) . Negative_regulation CLU SLC12A5 15774713 1384638 Decreases in after neuronal injuries *result* in increases in [ [Cl-]i] and enhanced neuronal excitability due to depolarizing GABA responses . Negative_regulation CLU SLC12A5 21486764 2428444 Here we show that in primary hippocampal neuronal cultures the suppression of the function using two different shRNAs , dominant negative KCC2 mutant C568A or DIOA inhibitor , *increased* the intracellular chloride concentration [ [Cl?]i] and enhanced the toxicity induced by lipofectamine dependent oxidative stress or activation of the NMDA receptors . Negative_regulation CLU SLC17A5 12372949 996504 significantly *reduced* renal expression of intercellular adhesion molecule (ICAM)-1 , osteopontin , monocyte chemotactic protein (MCP)-1 , and transforming growth factor (TGF)-beta1 , as well as [clusterin] . Negative_regulation CLU SLC30A1 19288494 2063901 Expression of , previously shown to regulate Zn ( 2+ ) influx , increased following prolonged application of zinc or cadmium to the explants and *prevented* [clusterin] up-regulation by subsequent exposure to these ions . Negative_regulation CLU TIMP1 1311314 178806 In the *presence* of , the formation of a 92T4Cl proenzyme complex with TIMP prevents dimerization , formation of the complex with [ClI] , and activation of the 92T4Cl proenzyme by stromelysin , a related metalloprotease . Negative_regulation CLU TIMP1 21784140 2472476 In this work , we investigated if co-exposure of rats to these compounds leads to alterations in the expression of the genes encoding kidney injury molecule 1 (KIM-1) , metallopeptidase *inhibitor* 1 ( ) , [clusterin] , osteopontin , and neutrophil gelatinase associated lipocalin/lipocalin 2 ( NGAL ) , which have been proposed as urinary biomarkers for nephrotoxicity . Negative_regulation CLU TIMP1 23287709 2741973 We investigated the effect of cisplatin on the protein levels of kidney injury molecule (KIM)-1 , [clusterin] , calbindin , tissue *inhibitor* of metalloproteinase ( ) -1 , cystatin C (CysC) , ß2-microglobulin ( ß2-M ) and neutrophil gelatinase associated lipocalin ( NGAL ) , which have been recently identified as in vivo biomarkers of nephrotoxicity . Negative_regulation CLU TP53 14508108 1145218 Loss of functional in HCT116 : p53 ( -/- ) cells *augmented* [CLU] de novo synthesis after IR exposure . Negative_regulation CMC1 ARSA 158654 9699 *inhibited* [CMC] at relatively low concentrations . Negative_regulation CMC2 ARSA 158654 9698 *inhibited* [CMC] at relatively low concentrations . Negative_regulation CMC4 ARSA 158654 9700 *inhibited* [CMC] at relatively low concentrations . Negative_regulation CNP IL1B 16109311 1445233 Interestingly , both and TNF-alpha markedly *inhibited* the expression of MOG , [CNPase] , and PLP but not MBP , the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate ( PDTC ) . Negative_regulation CNP TNF 16109311 1445232 Interestingly , both IL-1beta and markedly *inhibited* the expression of MOG , [CNPase] , and PLP but not MBP , the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate ( PDTC ) . Negative_regulation CNR1 FOXO1 16690806 1584260 Silencing of using small interfering RNA oligonucleotides decreased IGFBP1 and DCN levels and *increased* [CNR1] , TIMP3 , and PRL levels . Negative_regulation CNR1 GLP1R 22100840 2509430 Combined stimulation of and *inhibition* of cannabinoid [CB1] receptor act synergistically to reduce food intake and body weight in the rat . Negative_regulation CNR2 SPHK1 20718749 2306757 In addition to this , S1P mediated relaxation was also reduced by [CB(2)] receptor antagonists and *inhibition* . Negative_regulation CNR2 TNF 21867920 2473673 Our data show that [CB(2)] receptor *mediated* cAMP formation , but not intracellular calcium , is crucially involved in the regulation of osteoclastogenesis , primarily by inhibiting macrophage chemotaxis and expression . Negative_regulation CNTN2 TNF 17314097 1719497 Interestingly , peptides spanning CCR2 and/or LZ disrupt [IKKgamma-Tax] and IKKgamma-PP2A interactions and potently *inhibit* NF-kappaB activation by Tax and . Negative_regulation COA1 FAS 11444828 834127 We have previously shown that inhibition *causes* a rapid increase in [malonyl-CoA] levels identifying malonyl-CoA as a potential trigger of apoptosis . Negative_regulation COA1 FAS 16740734 1566506 Collectively , our results indicate that inhibition of in breast cancer cells *causes* accumulation of [malonyl-CoA] , which leads to inhibition of CPT-1 and up-regulation of ceramide and induction of the proapoptotic genes BNIP3 , TRAIL , and DAPK2 , resulting in apoptosis . Negative_regulation COA1 FAS 18719599 1955833 Inhibitors of , administered systemically or intracerebroventricularly to mice , *increase* hypothalamic [malony-CoA] and suppress food intake . Negative_regulation COA1 FOXO1 16997836 1640791 Increased activity *resulted* in up-regulation of hepatic peroxisome proliferator activated receptor-gamma coactivator-1beta , fatty acid synthase , and acetyl [CoA] carboxylase expression , accounting for increased hepatic fat infiltration . Negative_regulation COA1 TNF 2566909 112846 To investigate the mechanisms by which *prevents* [acetyl-CoA] carboxylase mRNA accumulation , we determined the effect of TNF on the transcription rate of the carboxylase gene and the half-life of carboxylase mRNA . Negative_regulation COA3 FAS 11444828 834129 We have previously shown that inhibition *causes* a rapid increase in [malonyl-CoA] levels identifying malonyl-CoA as a potential trigger of apoptosis . Negative_regulation COA3 FAS 16740734 1566508 Collectively , our results indicate that inhibition of in breast cancer cells *causes* accumulation of [malonyl-CoA] , which leads to inhibition of CPT-1 and up-regulation of ceramide and induction of the proapoptotic genes BNIP3 , TRAIL , and DAPK2 , resulting in apoptosis . Negative_regulation COA3 FAS 18719599 1955835 Inhibitors of , administered systemically or intracerebroventricularly to mice , *increase* hypothalamic [malony-CoA] and suppress food intake . Negative_regulation COA3 FOXO1 16997836 1640793 Increased activity *resulted* in up-regulation of hepatic peroxisome proliferator activated receptor-gamma coactivator-1beta , fatty acid synthase , and acetyl [CoA] carboxylase expression , accounting for increased hepatic fat infiltration . Negative_regulation COA3 TNF 2566909 112848 To investigate the mechanisms by which *prevents* [acetyl-CoA] carboxylase mRNA accumulation , we determined the effect of TNF on the transcription rate of the carboxylase gene and the half-life of carboxylase mRNA . Negative_regulation COA4 FAS 11444828 834128 We have previously shown that inhibition *causes* a rapid increase in [malonyl-CoA] levels identifying malonyl-CoA as a potential trigger of apoptosis . Negative_regulation COA4 FAS 16740734 1566507 Collectively , our results indicate that inhibition of in breast cancer cells *causes* accumulation of [malonyl-CoA] , which leads to inhibition of CPT-1 and up-regulation of ceramide and induction of the proapoptotic genes BNIP3 , TRAIL , and DAPK2 , resulting in apoptosis . Negative_regulation COA4 FAS 18719599 1955834 Inhibitors of , administered systemically or intracerebroventricularly to mice , *increase* hypothalamic [malony-CoA] and suppress food intake . Negative_regulation COA4 FOXO1 16997836 1640792 Increased activity *resulted* in up-regulation of hepatic peroxisome proliferator activated receptor-gamma coactivator-1beta , fatty acid synthase , and acetyl [CoA] carboxylase expression , accounting for increased hepatic fat infiltration . Negative_regulation COA4 TNF 2566909 112847 To investigate the mechanisms by which *prevents* [acetyl-CoA] carboxylase mRNA accumulation , we determined the effect of TNF on the transcription rate of the carboxylase gene and the half-life of carboxylase mRNA . Negative_regulation COA5 FAS 11444828 834130 We have previously shown that inhibition *causes* a rapid increase in [malonyl-CoA] levels identifying malonyl-CoA as a potential trigger of apoptosis . Negative_regulation COA5 FAS 16740734 1566509 Collectively , our results indicate that inhibition of in breast cancer cells *causes* accumulation of [malonyl-CoA] , which leads to inhibition of CPT-1 and up-regulation of ceramide and induction of the proapoptotic genes BNIP3 , TRAIL , and DAPK2 , resulting in apoptosis . Negative_regulation COA5 FAS 18719599 1955836 Inhibitors of , administered systemically or intracerebroventricularly to mice , *increase* hypothalamic [malony-CoA] and suppress food intake . Negative_regulation COA5 FOXO1 16997836 1640794 Increased activity *resulted* in up-regulation of hepatic peroxisome proliferator activated receptor-gamma coactivator-1beta , fatty acid synthase , and acetyl [CoA] carboxylase expression , accounting for increased hepatic fat infiltration . Negative_regulation COA5 TNF 2566909 112849 To investigate the mechanisms by which *prevents* [acetyl-CoA] carboxylase mRNA accumulation , we determined the effect of TNF on the transcription rate of the carboxylase gene and the half-life of carboxylase mRNA . Negative_regulation COA6 FAS 11444828 834126 We have previously shown that inhibition *causes* a rapid increase in [malonyl-CoA] levels identifying malonyl-CoA as a potential trigger of apoptosis . Negative_regulation COA6 FAS 16740734 1566505 Collectively , our results indicate that inhibition of in breast cancer cells *causes* accumulation of [malonyl-CoA] , which leads to inhibition of CPT-1 and up-regulation of ceramide and induction of the proapoptotic genes BNIP3 , TRAIL , and DAPK2 , resulting in apoptosis . Negative_regulation COA6 FAS 18719599 1955832 Inhibitors of , administered systemically or intracerebroventricularly to mice , *increase* hypothalamic [malony-CoA] and suppress food intake . Negative_regulation COA6 FOXO1 16997836 1640790 Increased activity *resulted* in up-regulation of hepatic peroxisome proliferator activated receptor-gamma coactivator-1beta , fatty acid synthase , and acetyl [CoA] carboxylase expression , accounting for increased hepatic fat infiltration . Negative_regulation COA6 TNF 2566909 112845 To investigate the mechanisms by which *prevents* [acetyl-CoA] carboxylase mRNA accumulation , we determined the effect of TNF on the transcription rate of the carboxylase gene and the half-life of carboxylase mRNA . Negative_regulation COG2 PCSK9 25051126 2948675 Accordingly , inhibition of activity has become an attractive *target* for drug development for lowering [LDL-C] , and human monoclonal antibodies against PCSK9 , are now in late-stage clinical development . Negative_regulation COL1A1 CHI3L1 19666003 2132686 secreted from adipose tissue *inhibits* degradation of [type I collagen] . Negative_regulation COL1A1 CHI3L1 19666003 2132688 purified from SVF cells *inhibited* the degradation of [type I collagen] , a major extracellular matrix of AT , by matrix metalloproteinase (MMP)-1 and increased rate of fibril formation of type I collagen . Negative_regulation COL1A1 CHI3L1 19666003 2132690 These results suggest that macrophage/preadipocyte interaction enhances degradation of type I collagen in AT , meanwhile , secreted from macrophages infiltrating into AT *inhibits* the [type I collagen] degradation . Negative_regulation COL1A1 CTGF 19565505 2104341 This study was undertaken to investigate the *role* of in enhanced expression of [type I collagen] in bleomycin induced lung fibrosis , and to delineate the mechanisms of action underlying the effects of CTGF on Col1a2 ( collagen gene type I alpha2 ) in this mouse model and in human pulmonary fibroblasts . Negative_regulation COL1A1 IL1B 19453649 2096998 [Polymerized-type I collagen] *induced* an increase of 3- to 6fold cell proliferation ( Ki-67 ) , proteoglycans content , and COMP and type II collagen expression , whereas it inhibited and TNF-alpha production . Negative_regulation COL1A1 IL1B 20471972 2288519 Inhibitory effects of baicalin on *induced* MMP-1/TIMP-1 and its stimulated effect on [collagen-I] production in human periodontal ligament cells . Negative_regulation COL1A1 IL1B 8891757 392030 In the human osteoblastic cell line MG-63 , IL-1 alpha ( 10-1000 pg/ml ) , ( 3-300 pg/ml ) and TNF-alpha ( 1-30 ng/ml ) stimulated prostaglandin E2 ( PGE2 ) formation and *inhibited* 1,25 ( OH ) 2-vitamin D3-induced osteocalcin biosynthesis as well as basal production of [type I collagen] . Negative_regulation COL1A1 MMP28 21855382 2500988 Increased renal expression was not *sufficient* to prevent homotrimeric [type I collagen] accumulation . Negative_regulation COL1A1 MMP7 21855382 2501003 Increased renal expression was not *sufficient* to prevent homotrimeric [type I collagen] accumulation . Negative_regulation COL1A1 PLAU 16144810 1499334 This was also associated with a decrease in mRNA expression , decreased plasmin activity , and *increased* [collagen I] mRNA expression . Negative_regulation COL1A1 TNF 10201951 605697 Earlier studies have documented that *inhibits* [type I collagen] gene ( COL1A2 ) expression at the transcriptional level , but the characterization of the transcription factors involved has been elusive . Negative_regulation COL1A1 TNF 15157666 1250571 In contrast , , whose matrix remodelling function is opposite to that of TGF-beta , *reduces* [type I collagen] gene expression . Negative_regulation COL1A1 TNF 15550448 1367856 Acetaldehyde enhances , whereas *inhibits* , transcription of the type I collagen promoters and [type I collagen] production . Negative_regulation COL1A1 TNF 16738527 1496692 In contrast , , whose matrix remodelling function is opposite to that of TGF-beta , *reduces* [type I collagen] gene expression . Negative_regulation COL1A1 TNF 19453649 2096997 [Polymerized-type I collagen] *induced* an increase of 3- to 6fold cell proliferation ( Ki-67 ) , proteoglycans content , and COMP and type II collagen expression , whereas it inhibited IL-1beta and production . Negative_regulation COL1A1 TNF 2122979 143942 and interferon-gamma *suppress* the activation of human [type I collagen] gene expression by transforming growth factor-beta 1 . Negative_regulation COL1A1 TNF 7636301 317458 In addition , TNF-R55-specific *suppressed* [type I collagen] mRNA levels as potently as wild-type TNF-alpha ( by 60 % ) . Negative_regulation COL1A1 TNF 8891757 392026 In the present study , the importance of prostaglandin formation in IL-1 and induced *inhibition* of osteocalcin and [type I collagen] formation has been examined . Negative_regulation COL1A1 TNF 8891757 392028 In the human osteoblastic cell line MG-63 , IL-1 alpha ( 10-1000 pg/ml ) , IL-1 beta ( 3-300 pg/ml ) and ( 1-30 ng/ml ) stimulated prostaglandin E2 ( PGE2 ) formation and *inhibited* 1,25 ( OH ) 2-vitamin D3-induced osteocalcin biosynthesis as well as basal production of [type I collagen] . Negative_regulation COL1A1 TNF 8891757 392039 Four non-steroidal antiinflammatory drugs , indomethacin , flurbiprofen , naproxen and meclofenamic acid , inhibited basal , IL-1 beta- and TNF-alpha stimulated PGE2 formation in the MG-63 cells without affecting IL-1 beta- or induced *inhibition* of osteocalcin and [type I collagen] formation . Negative_regulation COL1A1 TNF 8891757 392044 These data show that IL-1 and *inhibit* osteocalcin and [type I collagen] formation in osteoblasts independently of prostaglandin biosynthesis and that non-steroidal antiinflammatory drugs do not affect the effects of IL-1 and TNF on bone matrix biosynthesis . Negative_regulation COL1A1 TNF 8920984 396678 *suppressed* [COL1A1] promoter activity through proximal short promoter elements containing only 107 bp. Short substitution mutations between -101 and -97 bp or between -46 and -38 bp abolished TNF-alpha suppression of COL1A1 promoter activity . Negative_regulation COL1A1 TNF 8920984 396679 These results suggest that *suppressed* [COL1A1] promoter activity through elements located between -101 and -97 bp and between -46 and -38 bp of the COL1A1 promoter , and that the suppression involved DNA-protein interactions . Negative_regulation COL1A2 CHI3L1 19666003 2132687 secreted from adipose tissue *inhibits* degradation of [type I collagen] . Negative_regulation COL1A2 CHI3L1 19666003 2132689 purified from SVF cells *inhibited* the degradation of [type I collagen] , a major extracellular matrix of AT , by matrix metalloproteinase (MMP)-1 and increased rate of fibril formation of type I collagen . Negative_regulation COL1A2 CHI3L1 19666003 2132691 These results suggest that macrophage/preadipocyte interaction enhances degradation of type I collagen in AT , meanwhile , secreted from macrophages infiltrating into AT *inhibits* the [type I collagen] degradation . Negative_regulation COL1A2 CTGF 19565505 2104342 This study was undertaken to investigate the *role* of in enhanced expression of [type I collagen] in bleomycin induced lung fibrosis , and to delineate the mechanisms of action underlying the effects of CTGF on Col1a2 ( collagen gene type I alpha2 ) in this mouse model and in human pulmonary fibroblasts . Negative_regulation COL1A2 IL1B 19453649 2097000 [Polymerized-type I collagen] *induced* an increase of 3- to 6fold cell proliferation ( Ki-67 ) , proteoglycans content , and COMP and type II collagen expression , whereas it inhibited and TNF-alpha production . Negative_regulation COL1A2 IL1B 20471972 2288520 Inhibitory effects of baicalin on *induced* MMP-1/TIMP-1 and its stimulated effect on [collagen-I] production in human periodontal ligament cells . Negative_regulation COL1A2 IL1B 8891757 392033 In the human osteoblastic cell line MG-63 , IL-1 alpha ( 10-1000 pg/ml ) , ( 3-300 pg/ml ) and TNF-alpha ( 1-30 ng/ml ) stimulated prostaglandin E2 ( PGE2 ) formation and *inhibited* 1,25 ( OH ) 2-vitamin D3-induced osteocalcin biosynthesis as well as basal production of [type I collagen] . Negative_regulation COL1A2 MMP28 21855382 2501010 Increased renal expression was not *sufficient* to prevent homotrimeric [type I collagen] accumulation . Negative_regulation COL1A2 MMP7 21855382 2501025 Increased renal expression was not *sufficient* to prevent homotrimeric [type I collagen] accumulation . Negative_regulation COL1A2 PLAU 16144810 1499335 This was also associated with a decrease in mRNA expression , decreased plasmin activity , and *increased* [collagen I] mRNA expression . Negative_regulation COL1A2 TNF 10201951 605698 Earlier studies have documented that *inhibits* [type I collagen] gene ( COL1A2 ) expression at the transcriptional level , but the characterization of the transcription factors involved has been elusive . Negative_regulation COL1A2 TNF 12393755 1012841 Distinct involvement of the Jun-N-terminal kinase and NF-kappaB pathways in the *repression* of the human [COL1A2] gene by . Negative_regulation COL1A2 TNF 12393755 1012842 In JNK1-/ -- JNK2-/- (JNK-/-) fibroblasts , *inhibited* basal [COL1A2] expression but had no effect on TGF-beta-driven gene transactivation unless jnk1 was introduced ectopically . Negative_regulation COL1A2 TNF 15157666 1250572 In contrast , , whose matrix remodelling function is opposite to that of TGF-beta , *reduces* [type I collagen] gene expression . Negative_regulation COL1A2 TNF 15550448 1367857 Acetaldehyde enhances , whereas *inhibits* , transcription of the type I collagen promoters and [type I collagen] production . Negative_regulation COL1A2 TNF 16738527 1496693 In contrast , , whose matrix remodelling function is opposite to that of TGF-beta , *reduces* [type I collagen] gene expression . Negative_regulation COL1A2 TNF 19453649 2096999 [Polymerized-type I collagen] *induced* an increase of 3- to 6fold cell proliferation ( Ki-67 ) , proteoglycans content , and COMP and type II collagen expression , whereas it inhibited IL-1beta and production . Negative_regulation COL1A2 TNF 2122979 143944 and interferon-gamma *suppress* the activation of human [type I collagen] gene expression by transforming growth factor-beta 1 . Negative_regulation COL1A2 TNF 7636301 317459 In addition , TNF-R55-specific *suppressed* [type I collagen] mRNA levels as potently as wild-type TNF-alpha ( by 60 % ) . Negative_regulation COL1A2 TNF 8891757 392027 In the present study , the importance of prostaglandin formation in IL-1 and induced *inhibition* of osteocalcin and [type I collagen] formation has been examined . Negative_regulation COL1A2 TNF 8891757 392031 In the human osteoblastic cell line MG-63 , IL-1 alpha ( 10-1000 pg/ml ) , IL-1 beta ( 3-300 pg/ml ) and ( 1-30 ng/ml ) stimulated prostaglandin E2 ( PGE2 ) formation and *inhibited* 1,25 ( OH ) 2-vitamin D3-induced osteocalcin biosynthesis as well as basal production of [type I collagen] . Negative_regulation COL1A2 TNF 8891757 392040 Four non-steroidal antiinflammatory drugs , indomethacin , flurbiprofen , naproxen and meclofenamic acid , inhibited basal , IL-1 beta- and TNF-alpha stimulated PGE2 formation in the MG-63 cells without affecting IL-1 beta- or induced *inhibition* of osteocalcin and [type I collagen] formation . Negative_regulation COL1A2 TNF 8891757 392046 These data show that IL-1 and *inhibit* osteocalcin and [type I collagen] formation in osteoblasts independently of prostaglandin biosynthesis and that non-steroidal antiinflammatory drugs do not affect the effects of IL-1 and TNF on bone matrix biosynthesis . Negative_regulation COL2A1 ARSA 2734619 113543 The biosynthesis of [type II collagen] was *suppressed* to 70 % to 80 % of the control by indomethacin and . Negative_regulation COL2A1 EPHB2 16468044 1573940 Inhibitors of and NFkappaB could significantly *block* the induction of MMP-1 and -13 ( p < 0.05 ) and the repression of [collagen type II] ( p < 0.01 ) . Negative_regulation COL2A1 EPHB2 16622376 1551685 Moreover , inhibition of activity , in the presence TGF-beta3 , *resulted* in suppression of [collagen Type II] , aggrecan , TGF-beta-RI , TGF-beta-RII and TGF-beta-RIII mRNA expression . Negative_regulation COL2A1 IL1B 11037878 741249 The p38 MAPK-selective inhibitor , SB203580 , partially reversed *induced* inhibition of [COL2A1] mRNA levels and COL2A1-luciferase reporter gene expression . Negative_regulation COL2A1 IL1B 11037878 741251 These studies also show , for the first time , that p38 MAPK is one of the signals required for *induced* inhibition of [COL2A1] gene expression . Negative_regulation COL2A1 IL1B 12637574 1085761 Egr-1 mediates transcriptional *repression* of [COL2A1] promoter activity by . Negative_regulation COL2A1 IL1B 15659840 1350278 *induced* a decrease in [collagen type II] and upregulation of MMP-3 in a time dependent manner . Negative_regulation COL2A1 IL1B 15659840 1350280 In addition , *induced* a decrease in [type II collagen] , which was relieved by curcumin treatment . Negative_regulation COL2A1 IL1B 16754689 1590196 This study examined the possible involvement and regulatory mechanisms of Wnt signaling in induced *inhibition* of [type II collagen] expression in chondrocytes . Negative_regulation COL2A1 IL1B 17291458 1710973 Curcumin also reversed the *induced* down-regulation of [collagen type II] and beta1-integrin receptor expression . Negative_regulation COL2A1 IL1B 17404069 1721541 Resveratrol significantly reduced the *induced* inhibition of expression of cartilage-specific [collagen type II] and signal transduction receptor beta1-integrin in a time dependent manner . Negative_regulation COL2A1 IL1B 17454300 1730128 *inhibited* [type II collagen] expression , but activated CDK6 . Negative_regulation COL2A1 IL1B 17454300 1730131 However , overexpression of CDK6 inhibited type II collagen expression , whereas inhibition of CDK6 activity blocked *induced* suppression of [type II collagen] expression . Negative_regulation COL2A1 IL1B 18044710 1867302 We reported previously that early activation of EGR-1 by *results* in suppression of the proximal [COL2A1] promoter activity by displacement of Sp1 from GC boxes . Negative_regulation COL2A1 IL1B 18044710 1867306 Of the ETS factors tested , this response was specific to ESE-1 , since ESE-3 , which was also *induced* by , suppressed [COL2A1] promoter activity only weakly . Negative_regulation COL2A1 IL1B 18438857 1915457 Previous studies in our laboratory have shown that *represses* expression of the cartilage characteristic genes , cartilage derived retinoic acid-sensitive protein ( cd-rap ) and type II collagen ( [COL2A1] ) ; Negative_regulation COL2A1 IL1B 19453649 2097002 Polymerized-type I collagen *induced* an increase of 3- to 6fold cell proliferation ( Ki-67 ) , proteoglycans content , and COMP and [type II collagen] expression , whereas it inhibited and TNF-alpha production . Negative_regulation COL2A1 IL1B 21856929 2496231 Platelet-rich plasma releasate diminished induced *inhibition* of [COL2A1] and ACAN gene expression . Negative_regulation COL2A1 IL1B 3264290 101503 In this study we found that recombinant human *suppressed* synthesis of cartilage-specific [type II collagen] by cultured human costal chondrocytes associated with decreased steady state levels of alpha 1 ( II ) and alpha 1 ( IX ) procollagen mRNAs . Negative_regulation COL2A1 IL1B 9645953 514923 Compressive force promotes sox9 , [type II collagen] and aggrecan and *inhibits* expression resulting in chondrogenesis in mouse embryonic limb bud mesenchymal cells . Negative_regulation COL2A1 MAP2K6 14617631 1200695 Both inhibitors *increased* total [type II collagen] protein accumulation in micromass culture and elevated the activity of a transfected type II collagen enhancer-luciferase reporter gene . Negative_regulation COL2A1 MAP2K6 15250049 1271436 Type II collagen mRNA expression was expressed strongly during chondrogenesis and inhibition ( U0126 ) *resulted* in complete down-regulation of [type II collagen] . Negative_regulation COL2A1 MMP28 24363499 2881742 CM *enhanced* [type II collagen] expression in OA chondrocytes while decreasing activity in cell supernatants as well as the levels of MMP-3 and MMP-13 proteins and mRNA in OA chondrocytes stimulated with interleukin- (IL-) 1ß . Negative_regulation COL2A1 MMP7 24363499 2881757 CM *enhanced* [type II collagen] expression in OA chondrocytes while decreasing activity in cell supernatants as well as the levels of MMP-3 and MMP-13 proteins and mRNA in OA chondrocytes stimulated with interleukin- (IL-) 1ß . Negative_regulation COL2A1 TNF 18023359 1832153 Stimulation with or TNF-alpha and IL-10 significantly *inhibited* [collagen type II] and increased IL-10 and TNF-alpha mRNA expression . Negative_regulation COL2A1 TNF 19026560 2001499 *suppressed* [collagen type II] and aggrecan , but increased MMP and cytokine expression in chondrocytes compared to the non stimulated controls . Negative_regulation COL2A1 TNF 19453649 2097001 Polymerized-type I collagen *induced* an increase of 3- to 6fold cell proliferation ( Ki-67 ) , proteoglycans content , and COMP and [type II collagen] expression , whereas it inhibited IL-1beta and production . Negative_regulation COL2A1 TNF 22038356 2499435 The result showed that increased the expression of ß-catenin and MMP-13 , and significantly *inhibited* the synthesis of [type II collagen] and proteoglycan , which resulted in the degeneration of nucleus pulposus cells . Negative_regulation COL4A1 MMP28 11835393 911232 Plasminogen dependent [ 3H ] [-collagen IV] degradation was *inhibited* by inhibitor of uPA ( amiloride ) and ( phenanthroline ) and by antibodies against uPA or MMP-9 or alphavbeta6 integrin , indicating the involvement of alphavbeta6 integrin , uPA and MMP-9 in the process . Negative_regulation COL4A1 MMP7 11835393 911247 Plasminogen dependent [ 3H ] [-collagen IV] degradation was *inhibited* by inhibitor of uPA ( amiloride ) and ( phenanthroline ) and by antibodies against uPA or MMP-9 or alphavbeta6 integrin , indicating the involvement of alphavbeta6 integrin , uPA and MMP-9 in the process . Negative_regulation COL4A1 PLAU 24447806 2927145 In diabetic rats , *down-regulated* PAI-1 and [collagen IV] expression in mesangial matrix ( P < 0.05 ) . Negative_regulation COL4A1 PLAU 9573532 502463 Compared with the untreated hypercholesterolemic group , antioxidant therapy *induced* significant reductions in renal mRNA levels for procollagen III ( to 60 % of untreated levels ) , [collagen IV] ( 60 % ) , and TIMP-1 ( 20 % ) , while levels were significantly increased ( to 210 % ) . Negative_regulation COL4A1 TGM2 17223863 1689232 Inhibition of also *resulted* in loss of basement membrane [collagen IV] . Negative_regulation COL4A2 MMP28 11835393 911254 Plasminogen dependent [ 3H ] [-collagen IV] degradation was *inhibited* by inhibitor of uPA ( amiloride ) and ( phenanthroline ) and by antibodies against uPA or MMP-9 or alphavbeta6 integrin , indicating the involvement of alphavbeta6 integrin , uPA and MMP-9 in the process . Negative_regulation COL4A2 MMP7 11835393 911269 Plasminogen dependent [ 3H ] [-collagen IV] degradation was *inhibited* by inhibitor of uPA ( amiloride ) and ( phenanthroline ) and by antibodies against uPA or MMP-9 or alphavbeta6 integrin , indicating the involvement of alphavbeta6 integrin , uPA and MMP-9 in the process . Negative_regulation COL4A2 PLAU 24447806 2927146 In diabetic rats , *down-regulated* PAI-1 and [collagen IV] expression in mesangial matrix ( P < 0.05 ) . Negative_regulation COL4A2 PLAU 9573532 502464 Compared with the untreated hypercholesterolemic group , antioxidant therapy *induced* significant reductions in renal mRNA levels for procollagen III ( to 60 % of untreated levels ) , [collagen IV] ( 60 % ) , and TIMP-1 ( 20 % ) , while levels were significantly increased ( to 210 % ) . Negative_regulation COL4A2 TGM2 17223863 1689239 Inhibition of also *resulted* in loss of basement membrane [collagen IV] . Negative_regulation COL4A3 MMP28 11835393 911276 Plasminogen dependent [ 3H ] [-collagen IV] degradation was *inhibited* by inhibitor of uPA ( amiloride ) and ( phenanthroline ) and by antibodies against uPA or MMP-9 or alphavbeta6 integrin , indicating the involvement of alphavbeta6 integrin , uPA and MMP-9 in the process . Negative_regulation COL4A3 MMP7 11835393 911291 Plasminogen dependent [ 3H ] [-collagen IV] degradation was *inhibited* by inhibitor of uPA ( amiloride ) and ( phenanthroline ) and by antibodies against uPA or MMP-9 or alphavbeta6 integrin , indicating the involvement of alphavbeta6 integrin , uPA and MMP-9 in the process . Negative_regulation COL4A3 PLAU 24447806 2927147 In diabetic rats , *down-regulated* PAI-1 and [collagen IV] expression in mesangial matrix ( P < 0.05 ) . Negative_regulation COL4A3 PLAU 9573532 502465 Compared with the untreated hypercholesterolemic group , antioxidant therapy *induced* significant reductions in renal mRNA levels for procollagen III ( to 60 % of untreated levels ) , [collagen IV] ( 60 % ) , and TIMP-1 ( 20 % ) , while levels were significantly increased ( to 210 % ) . Negative_regulation COL4A3 TGM2 17223863 1689246 Inhibition of also *resulted* in loss of basement membrane [collagen IV] . Negative_regulation COL4A4 MMP28 11835393 911298 Plasminogen dependent [ 3H ] [-collagen IV] degradation was *inhibited* by inhibitor of uPA ( amiloride ) and ( phenanthroline ) and by antibodies against uPA or MMP-9 or alphavbeta6 integrin , indicating the involvement of alphavbeta6 integrin , uPA and MMP-9 in the process . Negative_regulation COL4A4 MMP7 11835393 911313 Plasminogen dependent [ 3H ] [-collagen IV] degradation was *inhibited* by inhibitor of uPA ( amiloride ) and ( phenanthroline ) and by antibodies against uPA or MMP-9 or alphavbeta6 integrin , indicating the involvement of alphavbeta6 integrin , uPA and MMP-9 in the process . Negative_regulation COL4A4 PLAU 24447806 2927148 In diabetic rats , *down-regulated* PAI-1 and [collagen IV] expression in mesangial matrix ( P < 0.05 ) . Negative_regulation COL4A4 PLAU 9573532 502466 Compared with the untreated hypercholesterolemic group , antioxidant therapy *induced* significant reductions in renal mRNA levels for procollagen III ( to 60 % of untreated levels ) , [collagen IV] ( 60 % ) , and TIMP-1 ( 20 % ) , while levels were significantly increased ( to 210 % ) . Negative_regulation COL4A4 TGM2 17223863 1689253 Inhibition of also *resulted* in loss of basement membrane [collagen IV] . Negative_regulation COL4A5 MMP28 11835393 911320 Plasminogen dependent [ 3H ] [-collagen IV] degradation was *inhibited* by inhibitor of uPA ( amiloride ) and ( phenanthroline ) and by antibodies against uPA or MMP-9 or alphavbeta6 integrin , indicating the involvement of alphavbeta6 integrin , uPA and MMP-9 in the process . Negative_regulation COL4A5 MMP7 11835393 911335 Plasminogen dependent [ 3H ] [-collagen IV] degradation was *inhibited* by inhibitor of uPA ( amiloride ) and ( phenanthroline ) and by antibodies against uPA or MMP-9 or alphavbeta6 integrin , indicating the involvement of alphavbeta6 integrin , uPA and MMP-9 in the process . Negative_regulation COL4A5 PLAU 24447806 2927149 In diabetic rats , *down-regulated* PAI-1 and [collagen IV] expression in mesangial matrix ( P < 0.05 ) . Negative_regulation COL4A5 PLAU 9573532 502467 Compared with the untreated hypercholesterolemic group , antioxidant therapy *induced* significant reductions in renal mRNA levels for procollagen III ( to 60 % of untreated levels ) , [collagen IV] ( 60 % ) , and TIMP-1 ( 20 % ) , while levels were significantly increased ( to 210 % ) . Negative_regulation COL4A5 TGM2 17223863 1689260 Inhibition of also *resulted* in loss of basement membrane [collagen IV] . Negative_regulation COL4A6 MMP28 11835393 911342 Plasminogen dependent [ 3H ] [-collagen IV] degradation was *inhibited* by inhibitor of uPA ( amiloride ) and ( phenanthroline ) and by antibodies against uPA or MMP-9 or alphavbeta6 integrin , indicating the involvement of alphavbeta6 integrin , uPA and MMP-9 in the process . Negative_regulation COL4A6 MMP7 11835393 911357 Plasminogen dependent [ 3H ] [-collagen IV] degradation was *inhibited* by inhibitor of uPA ( amiloride ) and ( phenanthroline ) and by antibodies against uPA or MMP-9 or alphavbeta6 integrin , indicating the involvement of alphavbeta6 integrin , uPA and MMP-9 in the process . Negative_regulation COL4A6 PLAU 24447806 2927150 In diabetic rats , *down-regulated* PAI-1 and [collagen IV] expression in mesangial matrix ( P < 0.05 ) . Negative_regulation COL4A6 PLAU 9573532 502468 Compared with the untreated hypercholesterolemic group , antioxidant therapy *induced* significant reductions in renal mRNA levels for procollagen III ( to 60 % of untreated levels ) , [collagen IV] ( 60 % ) , and TIMP-1 ( 20 % ) , while levels were significantly increased ( to 210 % ) . Negative_regulation COL4A6 TGM2 17223863 1689267 Inhibition of also *resulted* in loss of basement membrane [collagen IV] . Negative_regulation COL7A1 IL1B 15810887 1392142 We demonstrated that both TNF-alpha and *reduced* COL7A1 expression in epidermal keratinocytes in an additive manner , whereas they increased [COL7A1] expression in dermal fibroblasts . Negative_regulation COL7A1 LAMB3 18460030 1927027 Plasmin treated showed lower keratinocyte adhesion activity and *reduced* binding to [type VII collagen] . Negative_regulation COL7A1 TNF 15810887 1392141 We demonstrated that both and IL-1beta *reduced* [COL7A1] expression in epidermal keratinocytes in an additive manner , whereas they increased COL7A1 expression in dermal fibroblasts . Negative_regulation COMP IL1B 19453649 2097004 Polymerized-type I collagen *induced* an increase of 3- to 6fold cell proliferation ( Ki-67 ) , proteoglycans content , and [COMP] and type II collagen expression , whereas it inhibited and TNF-alpha production . Negative_regulation COMP MMP28 12853037 1109993 In this study we utilised well established bovine cartilage culture models to examine IL-1alpha stimulated [COMP] proteolysis in the *presence* and absence of inhibitors . Negative_regulation COMP MMP7 12853037 1110008 In this study we utilised well established bovine cartilage culture models to examine IL-1alpha stimulated [COMP] proteolysis in the *presence* and absence of inhibitors . Negative_regulation COMP TNF 19453649 2097003 Polymerized-type I collagen *induced* an increase of 3- to 6fold cell proliferation ( Ki-67 ) , proteoglycans content , and [COMP] and type II collagen expression , whereas it inhibited IL-1beta and production . Negative_regulation COMT MAOA 9444560 475292 Effect of and B and of [catechol-O-methyltransferase] *inhibition* on L-DOPA induced circling behavior . Negative_regulation COPS5 TNF 23636414 2805036 This was paralleled by an increased NF-?B-driven upregulation of atherogenic chemokines and adhesion molecules , as measured by qPCR and flow cytometry , and translated into an enhanced arrest of THP-1 monocytes on *stimulated* , [CSN5] depleted HUVECs . Negative_regulation CORT IL1B 8243265 236508 Recombinant rat ( rIL-1 beta ) when given ip *resulted* in dose dependent increases in plasma ACTH , [CORT] , and IL-6 concentrations . Negative_regulation CORT MMP28 11930228 894577 The disruption of was *induced* by [CORT] ( 10 ( 6 ) mol/L ) in hippocampal neurons cultured in hypoglycemic and serum free medium and antagonized by high concentration of glucose . Negative_regulation CORT MMP7 11930228 894592 The disruption of was *induced* by [CORT] ( 10 ( 6 ) mol/L ) in hippocampal neurons cultured in hypoglycemic and serum free medium and antagonized by high concentration of glucose . Negative_regulation CP TNF 7557864 327865 In contrast to Il-6 and Il-1 alpha , *reduced* the production of fibrinogen and [ceruloplasmin] but stimulated the production of ferritin . Negative_regulation CPA4 HDAC1 12552318 1057024 Because [CPA4] was originally identified as a protein *induced* in a prostate cancer cell line ( PC-3 ) by inhibitors , and was located at the putative prostate cancer-aggressiveness locus at 7q32 , we investigated its imprinting status in fetal tissues and in adult benign hypertrophic prostate ( BPH ) . Negative_regulation CPA4 HDAC10 12552318 1057022 Because [CPA4] was originally identified as a protein *induced* in a prostate cancer cell line ( PC-3 ) by inhibitors , and was located at the putative prostate cancer-aggressiveness locus at 7q32 , we investigated its imprinting status in fetal tissues and in adult benign hypertrophic prostate ( BPH ) . Negative_regulation CPA4 HDAC11 12552318 1057023 Because [CPA4] was originally identified as a protein *induced* in a prostate cancer cell line ( PC-3 ) by inhibitors , and was located at the putative prostate cancer-aggressiveness locus at 7q32 , we investigated its imprinting status in fetal tissues and in adult benign hypertrophic prostate ( BPH ) . Negative_regulation CPA4 HDAC2 12552318 1057025 Because [CPA4] was originally identified as a protein *induced* in a prostate cancer cell line ( PC-3 ) by inhibitors , and was located at the putative prostate cancer-aggressiveness locus at 7q32 , we investigated its imprinting status in fetal tissues and in adult benign hypertrophic prostate ( BPH ) . Negative_regulation CPA4 HDAC3 12552318 1057026 Because [CPA4] was originally identified as a protein *induced* in a prostate cancer cell line ( PC-3 ) by inhibitors , and was located at the putative prostate cancer-aggressiveness locus at 7q32 , we investigated its imprinting status in fetal tissues and in adult benign hypertrophic prostate ( BPH ) . Negative_regulation CPA4 HDAC4 12552318 1057017 Because [CPA4] was originally identified as a protein *induced* in a prostate cancer cell line ( PC-3 ) by inhibitors , and was located at the putative prostate cancer-aggressiveness locus at 7q32 , we investigated its imprinting status in fetal tissues and in adult benign hypertrophic prostate ( BPH ) . Negative_regulation CPA4 HDAC5 12552318 1057021 Because [CPA4] was originally identified as a protein *induced* in a prostate cancer cell line ( PC-3 ) by inhibitors , and was located at the putative prostate cancer-aggressiveness locus at 7q32 , we investigated its imprinting status in fetal tissues and in adult benign hypertrophic prostate ( BPH ) . Negative_regulation CPA4 HDAC6 12552318 1057018 Because [CPA4] was originally identified as a protein *induced* in a prostate cancer cell line ( PC-3 ) by inhibitors , and was located at the putative prostate cancer-aggressiveness locus at 7q32 , we investigated its imprinting status in fetal tissues and in adult benign hypertrophic prostate ( BPH ) . Negative_regulation CPA4 HDAC7 12552318 1057020 Because [CPA4] was originally identified as a protein *induced* in a prostate cancer cell line ( PC-3 ) by inhibitors , and was located at the putative prostate cancer-aggressiveness locus at 7q32 , we investigated its imprinting status in fetal tissues and in adult benign hypertrophic prostate ( BPH ) . Negative_regulation CPA4 HDAC8 12552318 1057016 Because [CPA4] was originally identified as a protein *induced* in a prostate cancer cell line ( PC-3 ) by inhibitors , and was located at the putative prostate cancer-aggressiveness locus at 7q32 , we investigated its imprinting status in fetal tissues and in adult benign hypertrophic prostate ( BPH ) . Negative_regulation CPA4 HDAC9 12552318 1057019 Because [CPA4] was originally identified as a protein *induced* in a prostate cancer cell line ( PC-3 ) by inhibitors , and was located at the putative prostate cancer-aggressiveness locus at 7q32 , we investigated its imprinting status in fetal tissues and in adult benign hypertrophic prostate ( BPH ) . Negative_regulation CPA4 LXN 10051192 593043 The aim of the present study was to investigate the density , laminar distribution , size , morphology , and neurotransmitter phenotype of rat cortical neurons expressing , an *inhibitor* of [carboxypeptidase A] . Negative_regulation CPA4 LXN 10350638 617067 , a [carboxypeptidase A] *inhibitor* , is expressed in a cell type-specific manner in both central and peripheral nervous systems in the rat . Negative_regulation CPA4 LXN 10498275 647562 , a [carboxypeptidase A] *inhibitor* , is expressed in a subset of neurons in the infragranular layers of the lateral cortex in the rat . Negative_regulation CPA4 LXN 10698712 672002 , a [carboxypeptidase A] *inhibitor* , is expressed in rat peritoneal mast cells and is associated with granular structures distinct from secretory granules and lysosomes . Negative_regulation CPA4 LXN 11455960 766025 , a [carboxypeptidase A] *inhibitor* , is expressed in a cell type-specific manner in both central and peripheral nervous systems in the rat . Negative_regulation CPA4 LXN 14528447 1148979 We have shown previously that , a [carboxypeptidase A] *inhibitor* , is expressed in intrahemispheric corticocortical neurons from the second postnatal week in the rat ( Arimatsu et al. [ 1999 ] Cereb . Negative_regulation CPA4 LXN 15738388 1383021 Latexin , alias , *inhibits* human [CPA4] ( hCPA4 ) , whose expression is induced in prostate cancer cells after treatment with histone deacetylase inhibitors . Negative_regulation CPA4 LXN 9895311 586861 Neurons expressing , a [carboxypeptidase A] *inhibitor* , are restricted to lateral areas in the cerebral cortex of adult and early postnatal rats . Negative_regulation CPOX ALOX5 17887937 1797456 A mixed extract containing two naturally occurring flavonoids , baicalin from Scutellaria baicalensis and catechin from Acacia catechu , was tested for [cyclooxygenase (COX)] and <5-lipoxygenase (5-LOX)> *inhibition* via enzyme , cellular , and in vivo models . Negative_regulation CPOX ALOX5 18281656 1872427 We performed a randomized phase II trial to test the hypothesis that *inhibitors* of two eicosanoid pathways ( cyclooxygenase-2 [[COX-2] ] , celecoxib and <5-lipoxygenase> [ 5-LOX ] , zileuton ) added to chemotherapy would improve outcome in advanced non-small-cell lung cancer ( NSCLC ) . Negative_regulation CPOX ALOX5 24295787 2893998 Novel di-tertiary-butyl phenylhydrazones as dual inhibitors : synthesis , [COX/LOX] *inhibition* , molecular modeling , and insights into their cytotoxicities . Negative_regulation CPOX ARSA 10406241 629404 We have also shown that the protective effect of PC does not influence the ability of to *inhibit* mucosal [cyclooxygenase (COX)] activity in the stomach and other tissues . Negative_regulation CPOX ARSA 10406241 629405 The mechanism of mucosal protection provided by this compound is not related to any alteration in the ability of to *inhibit* mucosal [COX] activity . Negative_regulation CPOX ARSA 11303759 803683 In the present experiments , adult Mongolian gerbils were chronically treated with , a non-selective [COX] *inhibitor* , and the proliferation of cells in the dentate gyrus was examined under ischemia . Negative_regulation CPOX ARSA 12668897 1075901 When [COX-l] is *inhibited* by or NSAIDs , PGE ( 2 ) synthesis stops and an enormous release of histamine and synthesis of LTs occurs . Negative_regulation CPOX ARSA 16618538 1562741 In order to clarify whether COX inhibitors directly inhibit A549 cell , three COX inhibitors , NS398 ( selective COX-2 inhibitor ) , SC560 ( selective COX-1 inhibitor ) , and acetyl salicylic acid ( , non-selective [COX] *inhibitor* ) , were studied . Negative_regulation CPOX ARSA 17329938 1706864 The activated cells were incubated with NS398 ( selective COX-2 inhibitor ) , SC560 ( selective COX-1 inhibitor ) , ( nonselective [COX] *inhibitor* ) at 37 degrees C for 15 min . Negative_regulation CPOX ARSA 22890587 2740211 NSAIDs and *inhibit* the same [COX-enzymes] , and thus may interact . Negative_regulation CPOX EPHB2 11208911 894816 However , both [COX] inhibitors *induced* activation of extracellular signal regulated kinase ( ) in neurones and phosphorylation of heavy molecular weight neurofilaments , cytoskeletal substrates of ERK . Negative_regulation CPOX IL1B 8931118 397841 Our findings indicate that caused an increase in AA release and COX activity and that in the presence of 1,25- ( OH ) 2D3 AA release , but not [COX] activity , is *suppressed* . Negative_regulation CPOX MMP28 21371008 2453176 up-regulation may be a *target* for [cyclooxygenase (COX)] and prostaglandin ( PG ) receptor inhibition , but the extent and mechanisms of COX independent MMP up-regulation are unclear . Negative_regulation CPOX MMP7 21371008 2453191 up-regulation may be a *target* for [cyclooxygenase (COX)] and prostaglandin ( PG ) receptor inhibition , but the extent and mechanisms of COX independent MMP up-regulation are unclear . Negative_regulation CPOX TNF 16518767 1531092 and interleukin-10 mRNA expression was elevated in H. pylori infected mice , but only TNF-alpha mRNA expression was further *increased* by [COX] deficiency . Negative_regulation CPOX TNF 19548191 2162488 The cardiovascular protective effect of RCLE seems to be due to an interplay of different factors : [COX] pathway activation , *inhibition* , endothelial nitric oxide synthase (eNOS) activation , and free radical and ROS scavenging . Negative_regulation CPOX TNF 22031851 2547571 Studies in mesangial cells and macrophages were carried out to establish that the in vivo increase in PLA(2) and COX were mediated by and IL-1ß and that curcumin , by antagonizing the cytokines , could significantly *reduce* both PLA(2) and [COX] . Negative_regulation CPOX TNFSF10 14670183 1178353 Moreover , coadministration of plus indomethacin , a pharmacological *inhibitor* of [cyclooxygenase (COX)] , showed an additive effect on SK-N-SH cell death . Negative_regulation CPP EPHB2 18940233 1989098 However , the *roles* of in the morphine paired [conditioned place preference (CPP)] are not clear . Negative_regulation CPSF1 SCARA3 18806823 2021204 A mutant unable to bind to CPSF3 did not alter CPSF3 subcellular distribution , did not *inhibit* its [polyadenylation] activity and did not induce cell death . Negative_regulation CPSF2 SCARA3 18806823 2021205 A mutant unable to bind to CPSF3 did not alter CPSF3 subcellular distribution , did not *inhibit* its [polyadenylation] activity and did not induce cell death . Negative_regulation CPSF3 SCARA3 18806823 2021206 A mutant unable to bind to CPSF3 did not alter CPSF3 subcellular distribution , did not *inhibit* its [polyadenylation] activity and did not induce cell death . Negative_regulation CPT1A LPCAT1 20018880 2210800 Overexpression of *increased* degradation of [CPT1] ( cholinephosphotransferase ) , a resident Golgi enzyme that catalyzes the terminal step for de novo PtdCho synthesis . Negative_regulation CPT1A PGC 23602251 2774495 Overexpression of wild-type , but not mutant PGC-1a , also *caused* a significant increase in hepatocyte expression of [carnitine palmitoyl transferase 1a] , a rate determining enzyme that transfers long-chain fatty acids into mitochondria for oxidation . Negative_regulation CPT2 PGC 21486805 2417691 Suppression of endogenous STARS reduced basal [Cpt-1ß] levels by 8.2-fold and *inhibited* the induced increase in Cpt-1ß mRNA . Negative_regulation CPZ TNF 8443968 213629 [CPZ] , DEX and completely *prevented* LPS lethality but not pulmonary oedema or pulmonary PMN infiltration , indicating that : ( i ) lung oedema is not the main cause of death after LPS ; Negative_regulation CR1 IL1B 9142862 428539 During reoxygenation , both whole blood PMN phagocytosis and bactericidal activity were reduced in the presence of IL-8 , TNF-alpha , or , and in subsets of PMN with reduced phagocytosis H/R *reduced* CD64 , CD32w , CD16 , [CD35] , and CD11b/CD18 expression in the presence of each cytokine . Negative_regulation CR1 TNF 9142862 428538 During reoxygenation , both whole blood PMN phagocytosis and bactericidal activity were reduced in the *presence* of IL-8 , , or IL-1beta , and in subsets of PMN with reduced phagocytosis H/R reduced CD64 , CD32w , CD16 , [CD35] , and CD11b/CD18 expression in the presence of each cytokine . Negative_regulation CRAT TNF 10670695 578719 [pPGHS1CAT] expression in amnion derived AV3 cells was *inhibited* by the pro-inflammatory cytokines and interleukin 1-beta (IL-1beta) . Negative_regulation CRAT TNF 21147697 2356184 Plasma levels of however did not show any significant changes in STZ induced diabetic rats fed with CV. Antioxidant enzyme SOD showed no significant changes in all groups but [CAT] activity was *reduced* in STZ induced diabetic rats compared to the control . Negative_regulation CRAT TNF 8119149 250594 *inhibited* 1,25- ( OH ) 2D3 stimulated , but not basal , [CAT] activity . Negative_regulation CRAT TNF 8920984 396677 *inhibited* the [CAT] activity of fibroblasts transfected with plasmids containing 2.3 kb of 5 ' flanking sequences of COL1A1 , whereas the activity of control plasmids containing the herpes simplex thymidine kinase promoter gene ( pBLCAT ) was unaltered . Negative_regulation CREB1 EFNB1 18403216 1920325 Moreover , the receptor complex specifically *enhances* the ability of alpha7-nAChRs to activate the transcription factor [CREB] , acting through a pathway including a receptor tyrosine kinase , a Src family member , PI3 kinase , and protein kinase A most distally . Negative_regulation CREB1 EPHB2 15193999 1259705 The effect of FK960 on c-Fos was inhibited by PD98059 ( 10microM ) , an kinase inhibitor , and cycloheximide ( 1microg/ml ) , a transcription inhibitor , and the effect of FK960 on [CREB] phosphorylation was *blocked* by PD98059 . Negative_regulation CREB1 EPHB2 18403216 1920327 Moreover , the receptor complex specifically *enhances* the ability of alpha7-nAChRs to activate the transcription factor [CREB] , acting through a pathway including a receptor tyrosine kinase , a Src family member , PI3 kinase , and protein kinase A most distally . Negative_regulation CREB1 EPHB2 19279268 2046354 Thus , when rats were re-exposed to the conditioning context for retrieval of pain experience , ERK and [CREB] were reactivated in the rACC , and *inhibiting* activation blocked the expression of F-CPA . Negative_regulation CREB1 EPHB2 20015475 2200065 Pretreatment of U87-MG cells with the ERK inhibitor PD98059 , accentuated ERK inhibition and increased CREB phosphorylation at Ser-133 and CREB-driven transcription stimulated by PGE ( 2 ) , suggesting that inhibition of *contributes* to PGE ( 2 ) -induced [CREB] activation . Negative_regulation CREB1 IL1B 12388341 1012752 also *attenuated* dibutyryl cAMP induced CRE-driven gene expression , but not dibutyryl cAMP induced [CREB] phosphorylation . Negative_regulation CREB1 MAP2K6 10406459 629465 These results suggest that a basal level of activity is *necessary* for both PDGF- and forskolin induced [CREB] activation , independent of CREB Ser-133 phosphorylation . Negative_regulation CREB1 MAP2K6 11885780 894052 The *activations* of [CREB] and NF-kappaB were blocked by inhibitors of either p38 ( SB-203580 ) or ( PD-098059 ) , suggesting that they were events downstream of MAK kinase . Negative_regulation CREB1 MAP2K6 19620255 2137522 Rather , the H2O2 dependent decrease in [CREB] protein is *prevented* by the proteasome inhibitor lactacystin , by inhibitors of or protein kinase C activity , or by adenoviral mediated delivery of a small interfering RNA that decreases PKD1 expression . Negative_regulation CREB1 MAP2K6 19937254 2240943 Interestingly , in non-UVB exposed human melanocytes , a inhibitor *stimulated* the phosphorylation of [p38/CREB] which was associated with an increased production of MITF and KIT in a pattern similar to that induced by UVB . Negative_regulation CREB1 TNF 15857826 1418931 *caused* a moderate decrease in the binding of [CREB1] to its cognate CRE DNA binding site . Negative_regulation CREB1 TNF 16633733 1611874 On the other hand , TGF-beta2 and significantly *repressed* FSH stimulated transcriptional activation of [CREB] by 30 % ( P < 0.05 ) and 45 % ( P < 0.05 ) , respectively . Negative_regulation CREB3 EFNB1 18403216 1920331 Moreover , the receptor complex specifically *enhances* the ability of alpha7-nAChRs to activate the transcription factor [CREB] , acting through a pathway including a receptor tyrosine kinase , a Src family member , PI3 kinase , and protein kinase A most distally . Negative_regulation CREB3 EPHB2 15193999 1259706 The effect of FK960 on c-Fos was inhibited by PD98059 ( 10microM ) , an kinase inhibitor , and cycloheximide ( 1microg/ml ) , a transcription inhibitor , and the effect of FK960 on [CREB] phosphorylation was *blocked* by PD98059 . Negative_regulation CREB3 EPHB2 18403216 1920333 Moreover , the receptor complex specifically *enhances* the ability of alpha7-nAChRs to activate the transcription factor [CREB] , acting through a pathway including a receptor tyrosine kinase , a Src family member , PI3 kinase , and protein kinase A most distally . Negative_regulation CREB3 EPHB2 19279268 2046355 Thus , when rats were re-exposed to the conditioning context for retrieval of pain experience , ERK and [CREB] were reactivated in the rACC , and *inhibiting* activation blocked the expression of F-CPA . Negative_regulation CREB3 EPHB2 20015475 2200066 Pretreatment of U87-MG cells with the ERK inhibitor PD98059 , accentuated ERK inhibition and increased CREB phosphorylation at Ser-133 and CREB-driven transcription stimulated by PGE ( 2 ) , suggesting that inhibition of *contributes* to PGE ( 2 ) -induced [CREB] activation . Negative_regulation CREB3 IL1B 12388341 1012753 also *attenuated* dibutyryl cAMP induced CRE-driven gene expression , but not dibutyryl cAMP induced [CREB] phosphorylation . Negative_regulation CREB3 MAP2K6 10406459 629472 These results suggest that a basal level of activity is *necessary* for both PDGF- and forskolin induced [CREB] activation , independent of CREB Ser-133 phosphorylation . Negative_regulation CREB3 MAP2K6 11885780 894060 The *activations* of [CREB] and NF-kappaB were blocked by inhibitors of either p38 ( SB-203580 ) or ( PD-098059 ) , suggesting that they were events downstream of MAK kinase . Negative_regulation CREB3 MAP2K6 19620255 2137529 Rather , the H2O2 dependent decrease in [CREB] protein is *prevented* by the proteasome inhibitor lactacystin , by inhibitors of or protein kinase C activity , or by adenoviral mediated delivery of a small interfering RNA that decreases PKD1 expression . Negative_regulation CREB3 MAP2K6 19937254 2240950 Interestingly , in non-UVB exposed human melanocytes , a inhibitor *stimulated* the phosphorylation of [p38/CREB] which was associated with an increased production of MITF and KIT in a pattern similar to that induced by UVB . Negative_regulation CREB3 TNF 16633733 1611876 On the other hand , TGF-beta2 and significantly *repressed* FSH stimulated transcriptional activation of [CREB] by 30 % ( P < 0.05 ) and 45 % ( P < 0.05 ) , respectively . Negative_regulation CREB5 EFNB1 18403216 1920319 Moreover , the receptor complex specifically *enhances* the ability of alpha7-nAChRs to activate the transcription factor [CREB] , acting through a pathway including a receptor tyrosine kinase , a Src family member , PI3 kinase , and protein kinase A most distally . Negative_regulation CREB5 EPHB2 15193999 1259704 The effect of FK960 on c-Fos was inhibited by PD98059 ( 10microM ) , an kinase inhibitor , and cycloheximide ( 1microg/ml ) , a transcription inhibitor , and the effect of FK960 on [CREB] phosphorylation was *blocked* by PD98059 . Negative_regulation CREB5 EPHB2 18403216 1920321 Moreover , the receptor complex specifically *enhances* the ability of alpha7-nAChRs to activate the transcription factor [CREB] , acting through a pathway including a receptor tyrosine kinase , a Src family member , PI3 kinase , and protein kinase A most distally . Negative_regulation CREB5 EPHB2 19279268 2046353 Thus , when rats were re-exposed to the conditioning context for retrieval of pain experience , ERK and [CREB] were reactivated in the rACC , and *inhibiting* activation blocked the expression of F-CPA . Negative_regulation CREB5 EPHB2 20015475 2200064 Pretreatment of U87-MG cells with the ERK inhibitor PD98059 , accentuated ERK inhibition and increased CREB phosphorylation at Ser-133 and CREB-driven transcription stimulated by PGE ( 2 ) , suggesting that inhibition of *contributes* to PGE ( 2 ) -induced [CREB] activation . Negative_regulation CREB5 IL1B 12388341 1012751 also *attenuated* dibutyryl cAMP induced CRE-driven gene expression , but not dibutyryl cAMP induced [CREB] phosphorylation . Negative_regulation CREB5 MAP2K6 10406459 629458 These results suggest that a basal level of activity is *necessary* for both PDGF- and forskolin induced [CREB] activation , independent of CREB Ser-133 phosphorylation . Negative_regulation CREB5 MAP2K6 11885780 894044 The *activations* of [CREB] and NF-kappaB were blocked by inhibitors of either p38 ( SB-203580 ) or ( PD-098059 ) , suggesting that they were events downstream of MAK kinase . Negative_regulation CREB5 MAP2K6 19620255 2137515 Rather , the H2O2 dependent decrease in [CREB] protein is *prevented* by the proteasome inhibitor lactacystin , by inhibitors of or protein kinase C activity , or by adenoviral mediated delivery of a small interfering RNA that decreases PKD1 expression . Negative_regulation CREB5 MAP2K6 19937254 2240936 Interestingly , in non-UVB exposed human melanocytes , a inhibitor *stimulated* the phosphorylation of [p38/CREB] which was associated with an increased production of MITF and KIT in a pattern similar to that induced by UVB . Negative_regulation CREB5 TNF 16633733 1611872 On the other hand , TGF-beta2 and significantly *repressed* FSH stimulated transcriptional activation of [CREB] by 30 % ( P < 0.05 ) and 45 % ( P < 0.05 ) , respectively . Negative_regulation CRH HSD11B2 23042946 2698570 Furthermore , inhibition of activity by 18ß-glycyrrhetinic acid *resulted* in elevated whole-body cortisol levels and preoptic area mRNA abundance of [corticotropin releasing factor] and mineralocorticoid receptor . Negative_regulation CRH IL1B 12535154 1049270 is *involved* in hypothalamic regulation of [corticotropin releasing hormone (CRH)] secretion and consequent downstream modulation of the neuroimmune response . Negative_regulation CRH IL1B 12864977 1111787 Lack of [CRH] attenuated LPS administration *induced* increase of mRNA expression in the spleen . Negative_regulation CRH IL1B 8381442 211962 Both and stress resulted in increased levels of CRF mRNA and when both were given together , the combination *resulted* in an additive effect on the increase in [CRF] transcripts . Negative_regulation CRIP1 MMP28 24812324 2944812 Mechanistically , miR-712 stimulated MMP activity in the aortic wall by directly targeting 2 inhibitors : tissue inhibitor of metalloproteinase 3 ( TIMP3 ) and reversion *inducing* [cysteine-rich protein] with kazal motifs ( RECK ) . Negative_regulation CRIP1 MMP7 24812324 2944827 Mechanistically , miR-712 stimulated MMP activity in the aortic wall by directly targeting 2 inhibitors : tissue inhibitor of metalloproteinase 3 ( TIMP3 ) and reversion *inducing* [cysteine-rich protein] with kazal motifs ( RECK ) . Negative_regulation CRIP2 MMP28 24812324 2944834 Mechanistically , miR-712 stimulated MMP activity in the aortic wall by directly targeting 2 inhibitors : tissue inhibitor of metalloproteinase 3 ( TIMP3 ) and reversion *inducing* [cysteine-rich protein] with kazal motifs ( RECK ) . Negative_regulation CRIP2 MMP7 24812324 2944849 Mechanistically , miR-712 stimulated MMP activity in the aortic wall by directly targeting 2 inhibitors : tissue inhibitor of metalloproteinase 3 ( TIMP3 ) and reversion *inducing* [cysteine-rich protein] with kazal motifs ( RECK ) . Negative_regulation CRIP3 MMP28 24812324 2944790 Mechanistically , miR-712 stimulated MMP activity in the aortic wall by directly targeting 2 inhibitors : tissue inhibitor of metalloproteinase 3 ( TIMP3 ) and reversion *inducing* [cysteine-rich protein] with kazal motifs ( RECK ) . Negative_regulation CRIP3 MMP7 24812324 2944805 Mechanistically , miR-712 stimulated MMP activity in the aortic wall by directly targeting 2 inhibitors : tissue inhibitor of metalloproteinase 3 ( TIMP3 ) and reversion *inducing* [cysteine-rich protein] with kazal motifs ( RECK ) . Negative_regulation CRK EPHB2 12482999 1024629 It inhibited phosphorylation , but did not *inhibit* [p38] phosphorylation . Negative_regulation CRK EPHB2 16291589 1526017 Thus , our results suggested that tumor induced [p38] MAPK activation and *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation CRK EPHB2 16767222 1576565 The enhancing effects of HSP60 costimulation on Tregs involved innate signaling via TLR2 , *led* to activation of PKC , PI3K , and [p38] , and were further enhanced by inhibition of . Negative_regulation CRK EPHB2 17146999 1497045 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase *inhibitors* , [p38] MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to inhibit mucin secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation CRK EPHB2 17372934 1797738 Low pressure ( 20 mmHg ) , equivalent to normal tissue pressure , increases phagocytosis by primary monocytes and PMA differentiated THP-1 macrophages , in part by FAK and *inhibition* and [p38] activation . Negative_regulation CRK EPHB2 20664969 2298213 Immunoblot analysis demonstrated that oridonin treatment increased expression levels of p-JNK , [p-p38] , p-p53 and p21 , elevated the level of cyclin B1/p-Cdc2 ( Tyr15 ) complex , and *inhibited* the expression of . Negative_regulation CRK EPHB2 20881039 2347112 Extracellular signal regulated receptor kinase ( ) and [p38] mitogen activated protein kinase *inhibitors* ( U0126 and SB203580 ) were sufficient to block Nup hyperphosphorylation in EMCV infected or L-expressing cells . Negative_regulation CRK EPHB2 22913737 2734837 In the present study , we examined the effects of intracerebroventricular administration of extracellular signal regulated protein kinase- ( ) and [p38-specific] *inhibitors* , U0126 and PD169316 , respectively , on apoptosis induced by amyloid beta ( Aß ) in rats . Negative_regulation CRK EPHB2 23198898 2736293 In addition , cytokine levels of astrocytes gradually decreased due to extracellular signal regulated kinase ( ) , c-Jun N-terminal kinase (JNK) and [p38] *inhibitors* . Negative_regulation CRK EPHB2 24253595 2910443 We examined the *role* of in the regulation of MKP1 and JNK , and [p38] activities and apoptosis . Negative_regulation CRK EPHB2 24297112 2894180 Following treatment with mitogen activated protein kinase (MAPK) *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB203580 ( [p38] inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Negative_regulation CRK IFI27 19364817 2081511 We have previously identified the protein kinase p38alpha as a novel regulator of contact inhibition , as [p38alpha] is activated upon cell-cell contacts and p38alpha-deficient cells are *impaired* in both confluence induced proliferation arrest and ( Kip1 ) accumulation . Negative_regulation CRK IL1B 11854442 913947 Moreover , IL-1 beta stimulation of the cells caused the phosphorylation of [p38] and extracellular signal regulated kinase ( ERK ) , and induced COX-2 expression was *inhibited* by the pretreatment of WISH cells with a p38 inhibitor , in contrast ERK upstream inhibitor had no effect . Negative_regulation CRK IL1B 15031635 1183837 CQ reduced mRNA expression and strongly *inhibited* phosphorylation of mitogen activated protein kinase (MAPK) [p38] , and to a lesser extent c-Jun N-terminal kinase and extracellular signal regulated kinase 1/2 . Negative_regulation CRK IL1B 18313411 1897482 CO was found to increase p38 phosphorylation and [p38] inhibition using SB203580 increased iNOS protein levels in *response* to . Negative_regulation CRK MAP2K6 17146999 1497051 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , [p38] MAP kinase *inhibitors* , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to inhibit mucin secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation CRK MAP2K6 19915797 2197767 We confirmed the interaction between phospho-p38 and MAP4 using immunoprecipitation and found that SB203580 , a [p38/MAPK] *inhibitor* , increases and ( Glu ) overexpression decreases hypoxic cell viability . Negative_regulation CRK MAP2K6 24253595 2910449 We examined the *role* of in the regulation of MKP1 and JNK , and [p38] activities and apoptosis . Negative_regulation CRK TNF 12842450 1108423 SB203580 inhibition of [p38] activity did not affect HSP72 expression , or reverse NaArs inhibition of LPS *induced* production . Negative_regulation CRK TNF 14585994 1159340 In transfection studies , RIP1 and TRAF2 stimulate [p38] MAP kinase activation , and dominant negative forms of RIP1 and TRAF2 *inhibit* induced p38 MAP kinase activation . Negative_regulation CRK TNF 21925494 2492121 The drug also reduced M. leprae induced production and *inhibited* [p38] and ERK1/2 activation . Negative_regulation CRK TNF 23056531 2685378 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit a ( TNF-a production in cultured macrophages ) and in vitro MAPK [p38a] *inhibition* . Negative_regulation CRK TNF 9916683 587469 SB 203580 , a selective inhibitor of p38 , blocked [p38] and MAPKAPK-2 activation in the T cell clone but did not completely *inhibit* release . Negative_regulation CRKL EPHB2 11443118 850426 Overexpression of Lyn *induced* constitutive phosphorylation of [CrkL] and activation of Erk , whereas that of a Lyn mutant lacking the tyrosine kinase domain attenuated the Epo induced phosphorylation of CrkL and activation of . Negative_regulation CRP TGM2 20609741 2286378 The suppressed the rise of the proinflammatory cytokines interleukin-6 ( p = 0.02 ) and interleukin-8 ( p = 0.05 ) , and *reduced* the postoperative increase in [C-reactive protein] ( p = 0.04 ) . Negative_regulation CRS AXIN2 15790973 1386509 The *role* of in calvarial morphogenesis and [craniosynostosis] . Negative_regulation CRTC1 MSX1 22039046 2516808 [TorC1] *inhibitor* , rapamycin (Rap) , and glutamine synthetase inhibitor , , elicit responses grossly similar to those of limiting nitrogen , implicating both glutamine synthesis and TorC1 in the regulation of Gln3 and Gat1 . Negative_regulation CRY1 CA12 21307569 2393289 [Cry1Aa] binding to Bombyx mori aminopeptidase N and other Cry toxin binding proteins was *inhibited* by , a Cry toxin binding protein . Negative_regulation CRY1 TNF 19625730 2112688 Interaction of with TNFR1 ( Tnfrsf1a , CD120a , p55 ) , but not TNFR2 ( Tnfrsf1b , CD120b , p75 ) , *leads* to fast downregulation of gene expression of Dbp and upregulation of negative regulators of the molecular clock , Per1 and Per2 , [Cryptochrome-1 (Cry1)] , and Differentiated embryo chondrocytes-1 ( Dec1 ) . Negative_regulation CRYGEP CTGF 23827951 2820809 stimulation *resulted* in the significant production of IL-6 , IL-8 , [C-C motif ligand 2 (CCL2)] , CCL20 , MMP-1 and MMP-3 in FLSs in the presence , but not in the absence , of IL-1ß . Negative_regulation CSE CAPN8 15180919 1288670 These results suggest that [CSE] attenuates angiogenesis of PAEC and the mechanism *involves* inhibition of . Negative_regulation CSE SRGN 15047144 1224998 Whereas , exogenous supply of , an *inhibitor* of [cystathionine gamma-lyase (CSE)] , decreased the plasma H2S content and worsened HPH . Negative_regulation CSE SRGN 19783349 2147576 significantly *suppressed* the expression of [CSE] and decreased the H ( 2 ) S level , yet also aggravated the symptoms of AR . Negative_regulation CSE SRGN 22982226 2697876 However , the use of , a potent *inhibitor* of [CSE] , markedly enhanced the cell killing effect induced by radiation . Negative_regulation CSE SRGN 23830907 2834620 Contrariwise , hydroxylamine ( HA , a CBS inhibitor ) and DL-propargylglycine ( , a [CSE] *inhibitor* ) decreased formalin induced nociceptive behavior in both experimental groups . Negative_regulation CSE SRGN 24508802 2918777 , a [CSE] *inhibitor* , significantly decreased T-currents in Cav3 .2-HEK293 cells , but not in NG108-15 cells . Negative_regulation CSF1 ITGAL 1371132 179597 Stimulation of cells with antibodies to the monocyte surface Ag MAC-1 , , and ICAM-1 did not *result* in [M-CSF] secretion . Negative_regulation CSF1 TNF 8647916 366334 Cycloheximide treatment of MC3T3-E1 cells up-regulated CSF-1 mRNA , and compared to either agent alone , cycloheximide and in combination *resulted* in augmentation of [CSF-1] expression . Negative_regulation CSF1 TNF 8781564 380388 Stimulation of PKC depleted mesangial cells with either PMA or *inhibited* [M-CSF] mRNA transcripts . Negative_regulation CSF1R ITGB2 22399609 2566900 In this study , we treated three myeloid cell lines , , THP-1 , and U937 , with sunitinib , and a small-molecule [CSF-1R] *inhibitor* ( cFMS-I ) to test the anticancer effect of such treatment . Negative_regulation CSF2 IL1B 17077666 1642378 *enhanced* the mRNA and/or protein levels of granulocyte-macrophage colony stimulating factor ( [GM-CSF] ) , IL-8 , and monocyte chemotactic protein (MCP)-1 in HCE and IL-6 , IL-8 , MCP-3 , and regulated on T-cell activation expressed secreted ( RANTES ) in HCFs . Negative_regulation CSF2 IL1B 9700099 525182 stimulation *resulted* in a 15-fold induction of [GM-CSF] protein , which was associated with a corresponding 47-fold maximal induction of GM-CSF mRNA levels . Negative_regulation CSF2 IL6R 10671302 666720 The objective of this study was to investigate the pathophysiological *roles* of soluble ( sIL-6R ) in [cerebrospinal fluid (CSF)] . Negative_regulation CSF2 ITGB2 14613935 1187963 Co-stimulating and CD11b with activating antibodies *resulted* in NF-kappaB activation by [GM-CSF] and IL-8 in suspended cells . Negative_regulation CSF2 MAP2K6 18252806 1895842 Interestingly , , p38 , and IKK inhibitors *block* TNF-alpha induced IL-8 , IL-6 , and [GM-CSF] secretion and 12z invasion , whereas the PI3K inhibitors do not . Negative_regulation CSF2 SELL 1694883 135324 The regulation of LAM-1 expression was tested by treating various cell populations with cytokines or other stimuli for 0-90 min. Exposure of neutrophils , monocytes , and marrow myeloid cells to [GM-CSF] *induced* rapid and complete loss of from the cell surface , but had no effect on LAM-1 expression by lymphocytes . Negative_regulation CSF2 TF 3490395 64717 Purified iron saturated human *suppressed* release of [GM-CSF] only from the T4+ subset of lymphocytes . Negative_regulation CSF2 TNF 10754482 682700 Similarly , [GM-CSF] *induced* a slight inhibition ( P < 0.05 ) , whereas TGF-beta1 and almost blocked DNA synthesis ( P < 0.001 ) after 72h . Negative_regulation CSF2 TNF 12869027 1112132 IgG prevented induced CD106 membrane expression and an increase in [ Ca++]i , and *inhibited* the secretion of interleukin-6 (IL-6) and [macrophage-colony stimulating factor] ( M-CSF ) . Negative_regulation CSF2 TNF 1698795 141623 Specificity studies under conditions that prevent receptor internalization showed that the binding of IL-3 , [GM-CSF] , and IL-5 was not *inhibited* by , IL-1 beta , interferon (IFN)-gamma , or G-CSF . Negative_regulation CSF2 TNF 20435921 2288099 TBP and dose-dependently *inhibited* TNFalpha induced secretion of interleukin (IL)-6 , IL-8 , granulocyte [macrophage-colony stimulating factor] , and monocyte chemoattractant protein-1 in immortalized human endometriotic cells . Negative_regulation CSF2 TNF 2794062 119710 We conclude that participates in mediating meningeal inflammation associated with Hib experimental meningitis , and that DXM , when given before or with Hib LOS , *inhibits* [CSF] TNF production and modulates the meningeal inflammatory response . Negative_regulation CSF2 TNF 8062890 268717 The combined stimulation by IL-1 plus *resulted* in supra-additive increases in [GM-CSF] expression by +/+ ( - ) 1.LDA11 . Negative_regulation CSF2 TNF 8391545 224362 inhibits IFN-gamma induced HLA-DR expression and IFN-gamma *blocks* TNF-alpha dependent synoviocyte proliferation , collagenase production , and [GM-CSF] secretion . Negative_regulation CSF2 TNF 8958788 401717 Stimulation with *resulted* in an increased [GM-CSF] production in fibroblasts ( 361 +/- 14 pg/ml ) , HTh 74 ( 148 +/- 51 pg/ml ) and SW 1736 cultures ( 235 +/- 43 pg/ml ) . Negative_regulation CSF2 TNF 9103454 423281 In contrast [granulocyte-macrophage-CSF] and , to a greater extent , markedly *reduced* IL-1 binding . Negative_regulation CSF3 EPHB2 15671148 1366083 *Roles* of Stat3 and in [G-CSF] signaling . Negative_regulation CSF3 IL1B 10029158 591524 In the present study the *roles* of and TNF-alpha in DDTC mediated [G-CSF] induction were examined using human long-term bone marrow cultures ( hLTBMCs ) . Negative_regulation CSF3 SELL 9689553 522936 [Granulocyte-colony stimulating factor] *induced* Mac-1 expression in a dose dependent manner , whereas expression was unaffected or reduced at high concentrations . Negative_regulation CSF3 TNF 10029158 591523 In the present study the *roles* of IL-1beta and in DDTC mediated [G-CSF] induction were examined using human long-term bone marrow cultures ( hLTBMCs ) . Negative_regulation CSF3 TNF 10198397 605242 [G-CSF] did not affect rectal temperature or the plasma levels of cortisol and growth hormone but did *induce* increases in the plasma levels of IL-1 receptor antagonist and both soluble receptors within 2 h after injection . Negative_regulation CSF3 TNF 1826697 155269 In addition , G-CSF binding studies suggested that the *induced* decrease in [G-CSF] binding to PEM was probably due to a reduction in receptor number rather than receptor affinity . Negative_regulation CSF3 TNF 21552804 345715 We report that all-trans retinoic acid ( tRA ) synergizes with LPS to *enhance* the production of [granulocyte colony stimulating factor] ( G-CSF ) in PMA treated cells , whereas the production of granulocyte-macrophage CSF , interleukin 1-beta (IL-1-beta) , and is minimally affected by tRA . Negative_regulation CSF3 TNF 21566987 290623 t-RA stimulated LPS mediated [granulocyte colony stimulating factor] ( G-CSF ) secretion over two-fold and *inhibited* both LPS mediated granulocyte-macrophage CSF (GM-CSF) and secretion by as much as 50 % . Negative_regulation CSF3 TNF 7513220 253676 , on the other hand , *suppresses* the [G-CSF] stimulated AML cell proliferation and serves as a modulator of growth factor receptors on AML cells . Negative_regulation CSF3R TNF 10729720 678248 , however , *down-regulated* [G-CSF receptor] expression . Negative_regulation CSH2 TNF 8060345 268228 *inhibits* expression of mouse [placental lactogen-II] through TNF-alpha type-I but not type-II receptor . Negative_regulation CSN2 ARSA 3588660 74094 Sodium cromoglycate ( 10 mg/kg ) selectively reduced the increases in CSN response to and IND. Phentolamine ( 0.2 mg/kg ) *inhibited* the increased [CSN] activity induced by ASA , IND , and TZ . Negative_regulation CSN2 FAS 21732136 2505234 *mediated* inhibition of [a-casein] to biotinylated hemin was neutralized with Ferrozine , but not NTA , while FAS- as well as ferric chloride mediated inhibition in their interaction was neutralized by NTA . Negative_regulation CSN2 TGM2 12162571 972215 Tyrosine melanin inhibited tissue-type in a competitive manner with a glutamine substrate , and also *inhibited* the cross linking of [casein] catalyzed by a tissue-type transglutaminase . Negative_regulation CSN2 TNF 15336944 1291312 and apigenin , a [casein kinase2 (CK2)] *inhibitor* , showed decreased CK2 phosphorylation and increased PTEN phosphorylation , which were reversed by KR-31378 . Negative_regulation CSN2 TNF 1572296 187213 In optimal lactogenic medium , ( 10-10,000 U/ml ) *inhibited* [casein] production . Negative_regulation CSN3 ARSA 3588660 74093 Sodium cromoglycate ( 10 mg/kg ) selectively reduced the increases in CSN response to and IND. Phentolamine ( 0.2 mg/kg ) *inhibited* the increased [CSN] activity induced by ASA , IND , and TZ . Negative_regulation CSN3 FAS 21732136 2505233 mediated *inhibition* of [a-casein] to biotinylated hemin was neutralized with Ferrozine , but not NTA , while FAS- as well as ferric chloride mediated inhibition in their interaction was neutralized by NTA . Negative_regulation CSN3 TGM2 12162571 972208 Tyrosine melanin inhibited tissue-type in a competitive manner with a glutamine substrate , and also *inhibited* the cross linking of [casein] catalyzed by a tissue-type transglutaminase . Negative_regulation CSN3 TNF 15336944 1291311 and apigenin , a [casein kinase2 (CK2)] *inhibitor* , showed decreased CK2 phosphorylation and increased PTEN phosphorylation , which were reversed by KR-31378 . Negative_regulation CSN3 TNF 1572296 187212 In optimal lactogenic medium , ( 10-10,000 U/ml ) *inhibited* [casein] production . Negative_regulation CSRP1 TNF 17100775 1644812 LPS , interleukin (IL)-1 , IL-6 and increased and IL-10 *reduced* [CRP] expression in PBMC . Negative_regulation CST6 AKT1 19074894 2003036 Breast cancer associated fibroblasts confer *mediated* epigenetic silencing of [Cystatin M] in epithelial cells . Negative_regulation CST6 CSTB 8263913 239261 In most of the solution NMR structures , this segment adopts a conformation more like that of , a family 1 [cystatin] *inhibitor* , as was observed in the crystal structure of its inhibitory complex with papain . Negative_regulation CST6 KNG1 9398600 469019 Paradoxically , addition of ( a [cystatin-like] protease *inhibitor* ) to the lysates before electrophoresis results in the appearance of additional bands of proteolytic activity in the 160-190 kDa molecular mass range . Negative_regulation CSTF1 SCARA3 18806823 2021207 A mutant unable to bind to CPSF3 did not alter CPSF3 subcellular distribution , did not *inhibit* its [polyadenylation] activity and did not induce cell death . Negative_regulation CSTF2 SCARA3 18806823 2021208 A mutant unable to bind to CPSF3 did not alter CPSF3 subcellular distribution , did not *inhibit* its [polyadenylation] activity and did not induce cell death . Negative_regulation CSTF3 SCARA3 18806823 2021209 A mutant unable to bind to CPSF3 did not alter CPSF3 subcellular distribution , did not *inhibit* its [polyadenylation] activity and did not induce cell death . Negative_regulation CTBS TNF 23666609 2827831 In vitro studies showed that *reduces* intracellular protein levels of [CtB] , CtL , and NPC2 , but increases their secretion in 3T3-L1 adipocytes . Negative_regulation CTD CDKN1C 20106982 2226562 RNA interference studies demonstrate that this activity is not an artifact of CDKN1C overexpression , because endogenous *mediates* an inhibition of RNA pol II [CTD] phosphorylation in HeLa cells upon treatment with dexamethasone . Negative_regulation CTD CFI 22290438 2565105 recruitment to this defined region may *result* from simultaneous binding to the Spt5 CTR , to nascent RNA containing the pA sequence , and to the elongating Pol II isoform that is phosphorylated at serine 2 ( S2 ) residues in its [C-terminal domain (CTD)] . Negative_regulation CTD PGC 18200011 1863538 Ectopic expression in somatic cells is *sufficient* to repress [CTD] Ser 2 phosphorylation . Negative_regulation CTF1 TNF 8939900 398545 Furthermore , is unable to *repress* [CTF-1] activity in NIH3T3 cells overexpressing ras or raf , suggesting that TNF-alpha regulates CTF-1 by a Ras-Raf kinase dependent pathway . Negative_regulation CTGF ACVRL1 21344387 2480404 Overexpression of constitutively active ( caALK1 ) in normal and SSc fibroblasts *led* to a moderate increase of collagen and [CCN2] . Negative_regulation CTGF ADIPOQ 21946149 2507235 *reduces* [connective tissue growth factor] in human hepatocytes which is already induced in non-fibrotic non-alcoholic steatohepatitis . Negative_regulation CTGF ADM 18401334 1920300 *inhibits* [connective tissue growth factor] expression , extracellular signal regulated kinase activation and renal fibrosis . Negative_regulation CTGF ADM 18401334 1920301 In this model , there is upregulation of [connective tissue growth factor (CTGF)] mRNA expression and extracellular signal regulated kinase ( ERK ) phosphorylation , and overexpression *suppressed* both of these activities without altering the blood pressure . Negative_regulation CTGF ADM 18401334 1920303 In NRK-49F renal fibroblasts , *reduced* transforming growth factor-beta induced [CTGF] and fibronectin mRNA upregulation through the cyclic AMP/protein kinase A signaling pathway , and suppressed ERK phosphorylation and cell proliferation . Negative_regulation CTGF AGTR2 14578193 1156662 Only treatment with an AT(1) receptor antagonist , but not an , *diminished* [CTGF] and fibronectin overexpression and ameliorated tubular damage . Negative_regulation CTGF AKT1 11018037 752832 Furthermore , overexpression of constitutive active was *sufficient* to induce [CTGF] gene expression , and inhibition of Akt activation by overexpressing dominant negative mutant of Akt abolished the VEGF induced CTGF expression . Negative_regulation CTGF AKT1 12218048 1012057 The *role* of p42/44 MAPK and in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Negative_regulation CTGF AKT1 19208742 2039205 Activation of FoxO transcription factors by inhibition of phosphatidylinositol <3-kinase/AKT> signaling *resulted* in a synergistic increase in CA-4P mediated [CTGF] induction . Negative_regulation CTGF AKT1 20201953 2259330 blockade using a specific pharmacological inhibitor and Akt siRNA *resulted* in a significant up-regulation of [CCN2] , which correlated with the increase in MMP1 . Negative_regulation CTGF AKT2 11018037 752833 Furthermore , overexpression of constitutive active was *sufficient* to induce [CTGF] gene expression , and inhibition of Akt activation by overexpressing dominant negative mutant of Akt abolished the VEGF induced CTGF expression . Negative_regulation CTGF AKT2 19208742 2039206 Activation of FoxO transcription factors by inhibition of phosphatidylinositol <3-kinase/AKT> signaling *resulted* in a synergistic increase in CA-4P mediated [CTGF] induction . Negative_regulation CTGF AKT2 20201953 2259331 blockade using a specific pharmacological inhibitor and Akt siRNA *resulted* in a significant up-regulation of [CCN2] , which correlated with the increase in MMP1 . Negative_regulation CTGF AKT3 11018037 752834 Furthermore , overexpression of constitutive active was *sufficient* to induce [CTGF] gene expression , and inhibition of Akt activation by overexpressing dominant negative mutant of Akt abolished the VEGF induced CTGF expression . Negative_regulation CTGF AKT3 19208742 2039207 Activation of FoxO transcription factors by inhibition of phosphatidylinositol <3-kinase/AKT> signaling *resulted* in a synergistic increase in CA-4P mediated [CTGF] induction . Negative_regulation CTGF AKT3 20201953 2259332 blockade using a specific pharmacological inhibitor and Akt siRNA *resulted* in a significant up-regulation of [CCN2] , which correlated with the increase in MMP1 . Negative_regulation CTGF AMOT 24101513 2858136 Concordant with phosphorylated Amot130 specifically mediating these effects , wild-type selectively induced YAP phosphorylation and *reduced* transcription of [connective tissue growth factor] in an AIP4 dependent manner versus Amot130 ( S175A ) . Negative_regulation CTGF ANG 23044205 2684657 ( 1-7 ) can *inhibit* the Ang II-stimulated up-regulation of RhoA , ROCK and [CTGF] in hepatic stellate cells , indicating that the ACE2-Ang ( 1-7 ) -Mas axis , an important branch of the renin-Ang-aldosterone system is involved in the occurrence and development of liver fibrosis . Negative_regulation CTGF BAI1 21170500 2356926 These results suggest that could *prevent* the up-regulation of [CTGF] expression in fibrotic lungs of rats receiving BLM instillation , which might be one of the mechanisms underlying the preventive effect of Bai on pulmonary fibrosis . Negative_regulation CTGF BAI2 21170500 2356927 These results suggest that could *prevent* the up-regulation of [CTGF] expression in fibrotic lungs of rats receiving BLM instillation , which might be one of the mechanisms underlying the preventive effect of Bai on pulmonary fibrosis . Negative_regulation CTGF BAI3 21170500 2356928 These results suggest that could *prevent* the up-regulation of [CTGF] expression in fibrotic lungs of rats receiving BLM instillation , which might be one of the mechanisms underlying the preventive effect of Bai on pulmonary fibrosis . Negative_regulation CTGF BMP7 19957515 2172835 dramatically suppressed the mRNA and protein expression of alpha-SMA , restored the expression of E-cadherin and *prevented* the expression of [CTGF] in a dose dependent manner after co-incubation with TGF-beta1 for 48 h ( 400 ng/ml BMP-7 + TGF-beta1 vs . TGF-beta1 , alone , P < 0.01 ) . Negative_regulation CTGF C1QTNF3 21351204 2499718 *inhibited* TGF-ß production and the expression of [CTGF] and collagen I in CLPF , whereas collagen III expression remained unchanged . Negative_regulation CTGF CAV1 22277251 2642803 This study was undertaken to evaluate the *role* of in Smad1 signaling and [CCN2] expression in healthy and SSc dermal fibroblasts . Negative_regulation CTGF CFD 24415895 2884171 Western blot analyses showed that *inhibited* the expression of FN , a-SMA , [CTGF] , TGFß1 , TGFß2 , Smad2/3 , and Smad4 . Negative_regulation CTGF COL1A1 22033529 2567952 TGF-ß1 stimulated mRNA expression of TGFB1 , CTGF , aSMA , and in keloid fibroblasts , while pirfenidone significantly *inhibited* mRNA expression of [CTGF] and aSMA in the identical cells . Negative_regulation CTGF CREB1 20053791 2211790 We conclude that forskolin stimulates *mediated* trans-activation of the Dot1 gene , which leads to hypermethylation of histone H3K79 at the CTGF promoter , and inhibition of [CTGF] transcription . Negative_regulation CTGF CREB3 20053791 2211791 We conclude that forskolin stimulates mediated trans-activation of the Dot1 gene , which leads to hypermethylation of histone H3K79 at the CTGF promoter , and *inhibition* of [CTGF] transcription . Negative_regulation CTGF CREB5 20053791 2211789 We conclude that forskolin stimulates mediated trans-activation of the Dot1 gene , which leads to hypermethylation of histone H3K79 at the CTGF promoter , and *inhibition* of [CTGF] transcription . Negative_regulation CTGF DCN 22280508 2545402 To assess the expression of , biglycan , versican , perlecan , fibronectin , dermatopontin , extracellular matrix protein 1 (ECM-1) , matrix metalloproteinase 1 , tissue *inhibitor* of metalloproteinase 1 , [connective tissue growth factor (CTGF)] , transforming growth factor ß1 , and Smad-3 protein , real-time RT-PCR and immunohistochemistry were performed on skin specimens obtained from the genital region of healthy subjects ( n = 10 ) as well as LS patients ( n = 26 ) . Negative_regulation CTGF DKK1 20299474 2281627 , a specific Wnt antagonist , also *attenuated* the high-glucose induced [CTGF] overexpression , indicating a role of Wnt signaling in CTGF overexpression in diabetes . Negative_regulation CTGF EDN1 16336267 1491295 Thereby , long-time stimulation by *resulted* in a changed ET-receptor subtype ratio and in a biphasic [CTGF] induction . Negative_regulation CTGF ENG 21769684 2461858 *inhibited* [CCN2] promoter activity in response to TGFß . Negative_regulation CTGF EPHB2 17428796 1742316 In lung fibroblasts , inhibition of the TGFbeta1 stimulated [CCN2/CTGF] by PGE ( 2 ) , butaprost , or forskolin is *due* to p38 , , and JNK MAP kinase inhibition that is cAMP dependent . Negative_regulation CTGF FGF2 9647791 516465 The binding of 125I labeled recombinant [CTGF] to HCS-2/8 cells was *inhibited* by unlabeled CTGF but not by PDGF-BB or . Negative_regulation CTGF FN1 15265370 1275312 PAI-1 and mRNA expression induced by TGF-beta1 was significantly *inhibited* by [CTGF] antisense ODNs . Negative_regulation CTGF FOXO1 19208742 2039203 Activation of transcription factors by inhibition of phosphatidylinositol 3-kinase/AKT signaling *resulted* in a synergistic increase in CA-4P mediated [CTGF] induction . Negative_regulation CTGF FOXO3 19208742 2039204 Activation of transcription factors by inhibition of phosphatidylinositol 3-kinase/AKT signaling *resulted* in a synergistic increase in CA-4P mediated [CTGF] induction . Negative_regulation CTGF FOXO4 19208742 2039208 Activation of transcription factors by inhibition of phosphatidylinositol 3-kinase/AKT signaling *resulted* in a synergistic increase in CA-4P mediated [CTGF] induction . Negative_regulation CTGF FOXO6 19208742 2039202 Activation of transcription factors by inhibition of phosphatidylinositol 3-kinase/AKT signaling *resulted* in a synergistic increase in CA-4P mediated [CTGF] induction . Negative_regulation CTGF GPS1 20540031 2367833 *mediated* down-regulation of TGF-ß1 and [CTGF] and up-regulation of Smad7 are essential for their effects of antifibrogenesis . Negative_regulation CTGF GPS2 20540031 2367834 *mediated* down-regulation of TGF-ß1 and [CTGF] and up-regulation of Smad7 are essential for their effects of antifibrogenesis . Negative_regulation CTGF GRAP2 17428796 1742317 In lung fibroblasts , inhibition of the TGFbeta1 stimulated [CCN2/CTGF] by PGE ( 2 ) , butaprost , or forskolin is *due* to , ERK , and JNK MAP kinase inhibition that is cAMP dependent . Negative_regulation CTGF HBZ 21705495 2465698 Finally , expression *resulted* in enhanced transcription of Pdgfb , Sox4 , [Ctgf] , Foxp3 , Runx1 , and Tsc22d1 genes and suppression of the Id2 gene ; Negative_regulation CTGF HDAC7 19404935 2075159 Most interestingly , TSA *induced* the expression of [CTGF] and ICAM-1 , while silencing of had no effect on their expression . Negative_regulation CTGF HGF 17164998 1661987 In addition , *suppressed* collagen synthesis and mRNA levels of procollagenalpha1 ( I ) and [connective tissue growth factor (CTGF)] in SSc fibroblasts . Negative_regulation CTGF HMOX1 22087023 2514165 The cardioprotective effects of in the late phase of infarct healing may be *mediated* partly by down-regulation of the profibrotic [connective tissue growth factor (CTGF)] , as HO-1 decreased CTGF expression at week 4 . Negative_regulation CTGF HSF1 18599869 1947147 In addition to reducing TM upregulation , inhibition of *reduced* statin induced upregulation of tissue plasminogen activator , whereas downregulation of thrombomospondin , plasminogen activator inhibitor 1 , or [connective tissue growth factor] was unaffected . Negative_regulation CTGF ID1 22099397 2585504 Smad1/Smad5 or overexpression *reduced* the TGF-ß1 mediated expression of [CTGF] . Negative_regulation CTGF ID2 22099397 2585505 Smad1/Smad5 or overexpression *reduced* the TGF-ß1 mediated expression of [CTGF] . Negative_regulation CTGF IFNG 17034590 1630964 *inhibited* the TGF-beta induced [CTGF] mRNA expression dose-dependently in dermal fibroblasts , but they failed to hamper the CoCl ( 2 ) -induced CTGF mRNA expression . Negative_regulation CTGF IGF1 18586434 1935265 however , GH did not affect CTGF expression in MAC-T cells , suggesting that may also *inhibit* [CTGF] expression in the mammary gland . Negative_regulation CTGF IGF1 18586434 1935271 Overall , these results suggest a novel biochemical and functional relationship between CTGF and IGF1 in the bovine mammary gland , where may *inhibit* [CTGF] expression to reduce the attenuating effect of CTGF on IGF1 stimulated proliferation of epithelial cells . Negative_regulation CTGF IHG1 18508967 1951849 In the HK-2 proximal tubule cell line , overexpression of *increased* TGF-beta1 stimulated expression of [connective tissue growth factor] and fibronectin . Negative_regulation CTGF IL1A 20205862 2223036 Stimulation of chondrocytes with PGE2 or significantly *suppressed* [CTGF] expression . Negative_regulation CTGF IL1A 20544797 2289872 and beta *inhibited* TGF-beta stimulated [CTGF] promoter activity , and the activity of a synthetic minimal promoter containing Smad 3-binding CAGA elements . Negative_regulation CTGF IL1A 20544797 2289873 In addition , RNA interference suggested that TGF-beta activated kinase1 (TAK1) is necessary for *inhibition* of TGF-beta stimulated [CTGF] expression . Negative_regulation CTGF IL1A 23454256 2776321 In conclusion , *reduced* [CCN2] expression and increased TNC expression in human CF. These observations are of potential value for understanding how inflammation and ECM regulation are linked at the level of the CF . Negative_regulation CTGF IL1B 17989112 1850952 did not increase the production of CTGF and type IV collagen but significantly *inhibited* ANG II-induced [CTGF] and type IV collagen overexpression . Negative_regulation CTGF IL4 11967989 938063 However , *attenuated* the TGF-beta stimulated induction of [CTGF] mRNA expression by 50 % . Negative_regulation CTGF JAK2 23108098 2721400 Thrombin induced CCN2 expression and [CCN2-Luc] activity were *attenuated* by a JAK inhibitor ( AG490 ) and , STAT3DN , and the STAT decoy ODN . Negative_regulation CTGF JUN 20222112 2281581 Further evidence of Smad3 and AP-1 involvement was seen when DN-Smad3 , SiRNA-Smad3 , Smad7 , and *suppressed* TGFbeta mediated activation of the [CTGF] promoter . Negative_regulation CTGF KLF15 18586263 1946831 The Kruppel-like factor *inhibits* [connective tissue growth factor (CTGF)] expression in cardiac fibroblasts . Negative_regulation CTGF KLF15 18586263 1946834 From a mechanistic standpoint , *inhibits* basal and TGFbeta1 mediated induction of the [CTGF] promoter . Negative_regulation CTGF LEFTY1 11991857 938599 inhibits Smad2 phosphorylation initiated by TGF-beta or its receptor and *prevents* [CTGF] promoter activity driven by TGF-beta . Negative_regulation CTGF LEFTY2 11991857 938598 inhibits Smad2 phosphorylation initiated by TGF-beta or its receptor and *prevents* [CTGF] promoter activity driven by TGF-beta . Negative_regulation CTGF LOX 21215756 2397020 Inhibition of [CTGF] by siRNA transfections completely inhibited AngII *induced* expression . Negative_regulation CTGF MAP2K1 15955090 1422000 Furthermore , co-expression of Smad3 with constitutively active *resulted* in potent induction of [CTGF] production without exogenous TGF-beta stimulation . Negative_regulation CTGF MAP3K5 23227240 2708234 [CTGF] mediated IL-6 production was *attenuated* by avß5 integrin neutralized antibody and ( ASK1 ) shRNA . Negative_regulation CTGF MAP3K7 20544797 2289874 In addition , RNA interference suggested that is *necessary* for IL-1 inhibition of TGF-beta stimulated [CTGF] expression . Negative_regulation CTGF MAPK1 12218048 1012058 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Negative_regulation CTGF MAPK1 16327498 1488498 inhibition *had* a similar effect on TGF-beta induced [CTGF] and fibronectin expression . Negative_regulation CTGF MAPK1 17907155 1812496 The inhibitor , U0126 , blocked MMP-1 activity and *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MAPK10 12218048 1012059 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Negative_regulation CTGF MAPK10 17907155 1812497 The inhibitor , U0126 , blocked MMP-1 activity and *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MAPK11 12218048 1012060 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Negative_regulation CTGF MAPK11 17907155 1812498 The inhibitor , U0126 , blocked MMP-1 activity and *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MAPK12 12218048 1012061 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Negative_regulation CTGF MAPK12 17907155 1812499 The inhibitor , U0126 , blocked MMP-1 activity and *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MAPK13 12218048 1012062 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Negative_regulation CTGF MAPK13 17907155 1812500 The inhibitor , U0126 , blocked MMP-1 activity and *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MAPK14 12218048 1012063 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Negative_regulation CTGF MAPK14 17907155 1812501 The inhibitor , U0126 , blocked MMP-1 activity and *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MAPK15 12218048 1012056 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Negative_regulation CTGF MAPK15 17907155 1812495 The inhibitor , U0126 , blocked MMP-1 activity and *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MAPK3 12218048 1012064 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Negative_regulation CTGF MAPK3 16327498 1488499 inhibition *had* a similar effect on TGF-beta induced [CTGF] and fibronectin expression . Negative_regulation CTGF MAPK3 17907155 1812502 The inhibitor , U0126 , blocked MMP-1 activity and *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MAPK4 12218048 1012065 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Negative_regulation CTGF MAPK4 17907155 1812503 The inhibitor , U0126 , blocked MMP-1 activity and *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MAPK6 12218048 1012066 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Negative_regulation CTGF MAPK6 17907155 1812504 The inhibitor , U0126 , blocked MMP-1 activity and *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MAPK7 12218048 1012067 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Negative_regulation CTGF MAPK7 17907155 1812505 The inhibitor , U0126 , blocked MMP-1 activity and *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MAPK8 12218048 1012068 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Negative_regulation CTGF MAPK8 17907155 1812506 The inhibitor , U0126 , blocked MMP-1 activity and *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MAPK9 12218048 1012069 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Negative_regulation CTGF MAPK9 17907155 1812507 The inhibitor , U0126 , blocked MMP-1 activity and *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MMP1 17907155 1812530 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MMP10 17907155 1812531 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MMP11 17907155 1812532 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MMP12 17907155 1812533 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MMP13 17907155 1812534 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MMP14 17907155 1812535 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MMP15 17907155 1812536 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MMP16 17907155 1812537 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MMP17 17907155 1812538 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MMP19 17907155 1812539 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MMP2 17907155 1812540 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MMP20 17907155 1812541 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MMP21 17907155 1812528 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MMP24 17907155 1812542 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MMP25 17907155 1812525 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MMP26 17907155 1812526 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MMP27 17907155 1812527 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MMP28 17907155 1812529 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MMP3 17907155 1812543 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MMP7 17907155 1812544 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MMP8 17907155 1812545 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MMP9 17907155 1812546 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Negative_regulation CTGF MYLIP 22395530 2606422 Interestingly , overexpression of could in turn negatively *regulated* TGF-ß and [connective tissue growth factor (CTGF)] expression and Smad3 signaling . Negative_regulation CTGF MYLIP 23681229 2785464 Finally , we further found that directly *suppressed* the expression of [CTGF] in NPC . Negative_regulation CTGF MYLIP 24296617 2904760 The *role* of in the regulation of Ang II-induced [CTGF] expression was evaluated in cultured cardiomyocytes with quantitative real-time reverse transcription polymerase chain reaction and Western blot analysis . Negative_regulation CTGF MYLIP 24296617 2904767 Finally , transfection of into cardiomyocytes *prevented* the upregulation of [CTGF] induced by Ang II . Negative_regulation CTGF NEUROG3 18616996 1972374 Both are induced by the WNT signaling pathway , and microarray data suggest that expression of WISP1 and [CTGF] is *repressed* by ( Ngn3 ( NEUROG3 ) ) , a transcription factor directing specification of the endocrine pancreas . Negative_regulation CTGF NOV 22698069 2659326 Furthermore , overexpressed in cultured primary hepatocytes *resulted* in decreased levels of [CCN2/CTGF] , the profibrotic marker protein in liver fibrosis . Negative_regulation CTGF NPY6R 21667293 2460004 [CCN2] was expressed in B16 ( F10 ) cells , and was *reduced* by the FAK/src inhibitor and the MEK/ERK inhibitor U0126 indicating that CCN2 acts downstream of these pathways in B16 ( F10 ) murine melanoma cells . Negative_regulation CTGF NPY6R 23108098 2721407 In addition , thrombin induced [CCN2] expression and CCN2-Luc activity were *inhibited* by c-SrcDN and ( an Src inhibitor ) . Negative_regulation CTGF OSM 22814105 2640028 *inhibits* TGF-ß1 induced [CTGF] expression via STAT3 in human proximal tubular cells . Negative_regulation CTGF OSM 22814105 2640029 In the present study we examined the *role* of TGF-ß1- and induced signaling mechanisms in the regulation of [CTGF] mRNA expression in human proximal tubular HK-2 cells . Negative_regulation CTGF OSM 22814105 2640035 However , knockdown of STAT3 but not STAT1 prevented *mediated* suppression of basal and TGF-ß1 induced upregulation of [CTGF] mRNA expression . Negative_regulation CTGF P2RX4 24574541 2942633 These findings showed that lack of expression leads to increased renal fibrosis , and *increased* expression of TGF-ß and [CTGF] in the UUO model . Negative_regulation CTGF PDGFB 9647791 516466 The binding of 125I labeled recombinant [CTGF] to HCS-2/8 cells was *inhibited* by unlabeled CTGF but not by or bFGF . Negative_regulation CTGF PIK3CA 19208742 2039209 Activation of FoxO transcription factors by inhibition of signaling *resulted* in a synergistic increase in CA-4P mediated [CTGF] induction . Negative_regulation CTGF PIK3R1 19208742 2039210 Activation of FoxO transcription factors by inhibition of signaling *resulted* in a synergistic increase in CA-4P mediated [CTGF] induction . Negative_regulation CTGF POLG2 18366626 1898678 In contrast , reduced the overall level of osteogenesis , and *reduced* BMP-2 secretion , RUNX-2 activity , [CTGF] levels and ALP activity at many of the timepoints examined . Negative_regulation CTGF PPARA 22550475 2590532 Pioglitazone treatment significantly increased expression and *inhibited* [CTGF] expression but had no effect on TGF-ß expression . Negative_regulation CTGF PPARG 11590167 882908 In addition , suppression of CTGF mRNA expression is relieved by pretreatment with an antagonist of PPAR gamma ( GW9662 ) , suggesting that the inhibition of [CTGF] expression is *mediated* by . Negative_regulation CTGF PPARG 11590167 882909 To elucidate further the molecular mechanism by which *inhibits* [CTGF] expression , an approximately 2-kilobase pair CTGF promoter was cloned . Negative_regulation CTGF PPARG 11590167 882910 We found that activation *inhibits* TGF-beta induced [CTGF] promoter activity in a dose dependent manner , and suppression of CTGF promoter activity by PPAR gamma activation is completely rescued by overexpression of Smad3 , but not by Smad4 . Negative_regulation CTGF PPARG 11590167 882914 Taken together , the data suggest that *inhibits* TGF-beta induced [CTGF] expression in HASMCs by directly interfering with the Smad3 signaling pathway . Negative_regulation CTGF PPARG 16723090 1565397 Furthermore , ligands significantly *suppressed* TGF-beta1 induced [CTGF] expression ( at both transcriptional and post-transcriptional levels ) in HSC , and the inhibitory effect was dramatically , if not completely , abolished by pretreatment with GW9662 , suggesting that the inhibition was indeed mediated by PPAR gamma . Negative_regulation CTGF PPARG 18658087 2010715 overexpression *suppressed* type I collagen , fibronectin , and [CTGF] in cultured hSCFs at the mRNA or protein level . Negative_regulation CTGF PPARG 19764552 2140676 It is supposed that rosiglitazone *inhibits* [CTGF] expression induced by TGF-beta1 in HLF-02 cells by activating through NF-kappaB and AP-1 signal transduction pathways . Negative_regulation CTGF PTEN 21654839 2475805 Overexpression of *reduced* the overexpression of type I collagen and [CCN2] by dSSc fibroblasts . Negative_regulation CTGF PTX3 15987746 1446766 Here , it was demonstrated that *inhibited* not only TGF-beta1 induced [CTGF] expression but also CTGF induced collagen I ( alpha1 ) [ Col I ( alpha1 ) ] expression in normal rat kidney fibroblasts ( NRK-49F ) and alpha-smooth muscle actin expression in normal rat kidney proximal tubular epithelial cells ( NRK-52E ) . Negative_regulation CTGF PTX3 15987746 1446773 Furthermore , *attenuated* tubulointerstitial fibrosis , myofibroblasts accumulation , and expression of [CTGF] and Col I ( alpha1 ) in unilateral ureteral obstruction kidneys . Negative_regulation CTGF PTX3 15987746 1446775 The mechanism by which *reduced* [CTGF] in NRK-49F and NRK-52E was investigated . Negative_regulation CTGF PTX3 15987746 1446784 In conclusion , these results indicate that *inhibits* [CTGF] expression by interfering with Smad3/4 dependent CTGF transcription through protein kinase A and blocks the profibrogenic effects of CTGF on renal cells . Negative_regulation CTGF PTX4 15987746 1446765 Here , it was demonstrated that *inhibited* not only TGF-beta1 induced [CTGF] expression but also CTGF induced collagen I ( alpha1 ) [ Col I ( alpha1 ) ] expression in normal rat kidney fibroblasts ( NRK-49F ) and alpha-smooth muscle actin expression in normal rat kidney proximal tubular epithelial cells ( NRK-52E ) . Negative_regulation CTGF PTX4 15987746 1446772 Furthermore , *attenuated* tubulointerstitial fibrosis , myofibroblasts accumulation , and expression of [CTGF] and Col I ( alpha1 ) in unilateral ureteral obstruction kidneys . Negative_regulation CTGF PTX4 15987746 1446774 The mechanism by which *reduced* [CTGF] in NRK-49F and NRK-52E was investigated . Negative_regulation CTGF PTX4 15987746 1446783 In conclusion , these results indicate that *inhibits* [CTGF] expression by interfering with Smad3/4 dependent CTGF transcription through protein kinase A and blocks the profibrogenic effects of CTGF on renal cells . Negative_regulation CTGF RAD1 21382976 2438201 Chromatin immunoprecipitation assay and co-immunoprecipitation further demonstrated that *inhibited* the binding of C/EBP-d to the [CTGF] promoter via direct interaction with C/EBP-d . Negative_regulation CTGF RAD1 21382976 2438208 *inhibits* [CTGF] expression through binding with C/EBP-d , thus regulating ECM production in the heart . Negative_regulation CTGF RAD17 21382976 2438202 Chromatin immunoprecipitation assay and co-immunoprecipitation further demonstrated that *inhibited* the binding of C/EBP-d to the [CTGF] promoter via direct interaction with C/EBP-d . Negative_regulation CTGF RAD17 21382976 2438209 *inhibits* [CTGF] expression through binding with C/EBP-d , thus regulating ECM production in the heart . Negative_regulation CTGF RAD18 21382976 2438200 Chromatin immunoprecipitation assay and co-immunoprecipitation further demonstrated that *inhibited* the binding of C/EBP-d to the [CTGF] promoter via direct interaction with C/EBP-d . Negative_regulation CTGF RAD18 21382976 2438207 *inhibits* [CTGF] expression through binding with C/EBP-d , thus regulating ECM production in the heart . Negative_regulation CTGF RAD21 21382976 2438203 Chromatin immunoprecipitation assay and co-immunoprecipitation further demonstrated that *inhibited* the binding of C/EBP-d to the [CTGF] promoter via direct interaction with C/EBP-d . Negative_regulation CTGF RAD21 21382976 2438210 *inhibits* [CTGF] expression through binding with C/EBP-d , thus regulating ECM production in the heart . Negative_regulation CTGF RAD50 21382976 2438204 Chromatin immunoprecipitation assay and co-immunoprecipitation further demonstrated that *inhibited* the binding of C/EBP-d to the [CTGF] promoter via direct interaction with C/EBP-d . Negative_regulation CTGF RAD50 21382976 2438211 *inhibits* [CTGF] expression through binding with C/EBP-d , thus regulating ECM production in the heart . Negative_regulation CTGF RAD51 21382976 2438205 Chromatin immunoprecipitation assay and co-immunoprecipitation further demonstrated that *inhibited* the binding of C/EBP-d to the [CTGF] promoter via direct interaction with C/EBP-d . Negative_regulation CTGF RAD51 21382976 2438212 *inhibits* [CTGF] expression through binding with C/EBP-d , thus regulating ECM production in the heart . Negative_regulation CTGF RAD52 21382976 2438206 Chromatin immunoprecipitation assay and co-immunoprecipitation further demonstrated that *inhibited* the binding of C/EBP-d to the [CTGF] promoter via direct interaction with C/EBP-d . Negative_regulation CTGF RAD52 21382976 2438213 *inhibits* [CTGF] expression through binding with C/EBP-d , thus regulating ECM production in the heart . Negative_regulation CTGF RHOA 12951326 1158059 Overexpression of constitutively active *induced* [CTGF] synthesis . Negative_regulation CTGF RHOA 15970428 1497762 Inhibition of the RhoA associated kinase or overexpression of dominant negative *reduced* the stimulated [CTGF] expression indicative of a role for RhoA signaling in CTGF expression . Negative_regulation CTGF RHOA 17215322 1732496 Overexpression of constitutively active or SRF significantly *increased* [CTGF] protein synthesis . Negative_regulation CTGF RUNX2 21986102 2539635 Forced expression of Runx2 decreased and the reduction of expression by small interfering RNA *enhanced* both basal and TGF-ß stimulated [CTGF] gene expression in HASMCs . Negative_regulation CTGF SERPINA3 20299474 2281615 The purpose of this study was to investigate the *role* of in the regulation of [CTGF] and fibrogenesis and its mechanism of action . Negative_regulation CTGF SERPINA3 20299474 2281618 *attenuated* the [CTGF] and fibronectin overexpression in retinas of diabetic rats . Negative_regulation CTGF SGK1 18846327 1976888 Overexpression of active in HMCs transfected with pIRES2-EGFP-S422D hSGK1 ( SD ) could *increase* the expression of phosphorylated SGK1 and [CTGF] as compared with HMCs groups transfected with pIRES2-EGFP ( FP ) under high glucose or normal glucose . Negative_regulation CTGF SGK1 22042038 2562579 The effects of aldosterone on ICAM-1 and [CTGF] promoter activities and protein expressions were *inhibited* by the transfection of dominant negative and dominant negative I?Ba . Negative_regulation CTGF SMAD1 15855807 1425629 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Negative_regulation CTGF SMAD1 22099397 2585506 or Id1/2 overexpression *reduced* the TGF-ß1 mediated expression of [CTGF] . Negative_regulation CTGF SMAD2 15377500 1353931 The proinflammatory cytokines tumor necrosis factor-alpha and IL-1 beta reduced TGF-beta 1-stimulated mRNA expression of [CTGF] but did not *inhibit* TGF-beta induced phosphorylation . Negative_regulation CTGF SMAD2 15855807 1425630 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Negative_regulation CTGF SMAD2 19610047 2130872 New results indicate that the methylxanthine caffeine -- a major component of coffee and the most widely consumed pharmacologically active substance in the world -- might be responsible for this phenomenon , because it *inhibits* the synthesis of [connective tissue growth factor] ( CTGF/CCN2 ) in liver parenchymal and nonparenchymal cells , primarily by inducing degradation of ( and to a much lesser extent Smad3 ) and thus impairment of transforming growth factor beta ( TGF-beta ) signaling . Negative_regulation CTGF SMAD2 19667256 2138721 Importantly , the ability of knockdown of Smad3 , but not , to *inhibit* Ang II-induced [CTGF] and collagen I expression further revealed an essential role for Smad3 in Ang II-mediated renal fibrosis . Negative_regulation CTGF SMAD2 21245987 2379908 The inhibition of TGFß1 driven [CCN2/CTGF] expression by IL-6 did not *involve* a modulation of ( and Smad1/3 ) signalling . Negative_regulation CTGF SMAD2 22211842 2629466 Deletion of Smad3 inhibits , whereas disruption of *upregulates* , [connective tissue growth factor] and vascular endothelial growth factor expression and promotes both epithelial-myofibroblast and endothelial-myofibroblast transition . Negative_regulation CTGF SMAD3 15377500 1353932 The proinflammatory cytokines tumor necrosis factor-alpha and IL-1 beta reduced TGF-beta 1-stimulated mRNA expression of [CTGF] but did not *inhibit* TGF-beta induced phosphorylation . Negative_regulation CTGF SMAD3 15855807 1425631 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Negative_regulation CTGF SMAD3 15955090 1421996 Adenoviral overexpression of Smad3 enhanced the TGF-beta elicited expression of CTGF , whereas Smad7 and dominant negative *suppressed* the effects of TGF-beta on [CTGF] and Cyr61 expression . Negative_regulation CTGF SMAD3 20222112 2281582 Further evidence of Smad3 and AP-1 involvement was seen when , SiRNA-Smad3 , Smad7 , and DN-AP-1 *suppressed* TGFbeta mediated activation of the [CTGF] promoter . Negative_regulation CTGF SMAD4 15855807 1425632 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Negative_regulation CTGF SMAD5 15855807 1425633 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Negative_regulation CTGF SMAD5 22099397 2585507 or Id1/2 overexpression *reduced* the TGF-ß1 mediated expression of [CTGF] . Negative_regulation CTGF SMAD6 15855807 1425634 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Negative_regulation CTGF SMAD7 15855807 1425635 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Negative_regulation CTGF SMAD7 16902401 1601346 gene transfer *suppressed* mRNA expressions of [connective tissue growth factor (CTGF)] , VEGF , and monocyte chemoattractant protein-1 in vivo and those of type-I collagen , alphaSMA , and CTGF in vitro . Negative_regulation CTGF SMAD7 17403017 1728225 Additionally , IFN-gamma treatment stimulated expression and *inhibited* [connective tissue growth factor] , which has been considered a key molecule to promote the transdifferentiation of myofibroblasts via TGF-beta1 activation . Negative_regulation CTGF SMAD7 17657819 1816247 In line with these data , hepatocyte-specific transgenic *reduced* [CTGF] expression in carbon tetrachloride treated animals , whereas in Smad7 knockout mice , it was enhanced . Negative_regulation CTGF SMAD7 20222112 2281583 Further evidence of Smad3 and AP-1 involvement was seen when DN-Smad3 , SiRNA-Smad3 , , and DN-AP-1 *suppressed* TGFbeta mediated activation of the [CTGF] promoter . Negative_regulation CTGF SMAD7 24090133 2867554 Inhibition of expression in CCD-1068SK fibroblasts *resulted* in increased [CCN2] expression , while Smad7 overexpression had the opposite effect . Negative_regulation CTGF SMAD9 15855807 1425636 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Negative_regulation CTGF SMN1 16324366 1490940 The [CTGF] mRNA expression of the HKC cells transfected with CTGF ASODN that was stimulated by TGF-beta1 10 microg/L was significantly suppressed ( P < 0.01 ) and the mRNA expression induced by TGF-beta1 10 microg/L was significantly *inhibited* by CTGF ASODN transfection ( P < 0.01 ) . Negative_regulation CTGF SOX9 20571031 2308988 Luciferase , electrophoretic mobility shift assay ( EMSA ) , and ChIP analysis revealed that *represses* [Ccn2] expression by binding to the consensus TCF x LEF x Sox9 site . Negative_regulation CTGF SP1 12888575 1150097 Blocking activity *reduces* the elevated , constitutive levels of [CTGF] promoter activity and protein expression observed in SSc fibroblasts . Negative_regulation CTGF SRC 23108098 2721396 In this study , we further investigated the *roles* of , JAK2 , and STAT3 in thrombin induced [CCN2] expression . Negative_regulation CTGF SRF 17215322 1732495 Overexpression of constitutively active RhoA or significantly *increased* [CTGF] protein synthesis . Negative_regulation CTGF STAT3 23108098 2721399 Thrombin induced CCN2 expression and [CCN2-Luc] activity were *attenuated* by a JAK inhibitor ( AG490 ) and JAK2DN , , and the STAT decoy ODN . Negative_regulation CTGF TCF21 17551956 1848377 Suppression of by siRNA *resulted* in increased cell proliferation and reduced expression of alphaSMA , fibronectin , and [CTGF] , and myofibroblast secreted proteins including pro-fibrotic cytokines and inhibitors of matrix metalloproteinases . Negative_regulation CTGF TEAD4 21701496 2532151 In contrast , *represses* expression of the growth factor [CTGF] ( connective tissue growth factor ) to promote differentiation . Negative_regulation CTGF TGFB1 16306131 1539378 Overexpression of [CTGF] during hepatic fibrogenesis is *induced* by . Negative_regulation CTGF TGFB1 18287089 1891391 does not stimulate RhoA activation in gingival fibroblasts , and the overexpression of dominant negative RhoA does not *reduce* [CCN2/CTGF] expression in response to TGFbeta1 . Negative_regulation CTGF TGFB1 19024301 1992308 The level of [CTGF] protein expression *induced* by was measured by immunocytochemistry , The mRNA expression of CTGF was evaluated by quantitative real time fluroscent polymerase chain reaction . Negative_regulation CTGF TGFB1 19127219 2047793 Treatment with JNK inhibitors also decreased normal branching morphogenesis and induced [CTGF] expression as well as augmented *inhibition* of branching and induction of CTGF expression . Negative_regulation CTGF TGFB1 20432467 2282447 In this study we demonstrate that activates Src kinase in ROS17/2.8 cells and that treatment with the Src family kinase inhibitor PP2 *prevents* Src activation and [CTGF] induction by TGF-beta1 . Negative_regulation CTGF TGFB1 22033529 2567951 TGF-ß1 stimulated mRNA expression of , CTGF , aSMA , and Col1A1 in keloid fibroblasts , while pirfenidone significantly *inhibited* mRNA expression of [CTGF] and aSMA in the identical cells . Negative_regulation CTGF TGFB2 16306131 1539379 Overexpression of [CTGF] during hepatic fibrogenesis is *induced* by . Negative_regulation CTGF TGFB3 16306131 1539380 Overexpression of [CTGF] during hepatic fibrogenesis is *induced* by . Negative_regulation CTGF TIMP1 15495827 1321977 AA-Na 40 microg/ml , with or without 10 % S-YRS , was co-cultured with hRIFs , then the hRIFs mRNA of transforming growth factor-beta1 ( TGF-beta1 ) , [connective tissue growth factor (CTGF)] , plasminogen activator inhibitor-1 ( PAI-1 ) , tissue *inhibitor* of metalloproteinase-1 ( ) and type I collagen ( Col I ) in the cultured cells were detected by RT-PCR , and their protein expression monitored with ELISA and Western blot respectively . Negative_regulation CTGF TIMP1 15864749 1401470 The inhibitory effects of Sm ( 50-400 microg/ml ) on TGF-beta1 induced alpha-smooth muscle actin ( alpha-SMA ) secretion and the mRNA expressions of fibrosis related genes , including alpha-SMA , [connective tissue growth factor (CTGF)] , and tissue *inhibitor* of metalloproteinase-1 ( ) , were assessed . Negative_regulation CTGF TIMP1 16321319 1487762 The mRNA and the protein expression of transforming growth factor-beta1 ( TGF-beta1 ) , [connective tissue growth factor (CTGF)] , plasminogen activator inhibitor-1 ( PAI-1 ) , tissue *inhibitor* of metalloproteinase-1 ( ) and collagen I (ColI) in kidney tissue was semi-quantitatively determined with reverse transcription-polymerase chain reaction ( RT-PCR ) and immunohistochemical staining , respectively . Negative_regulation CTGF TIMP1 16548356 1537866 The expressions of matrix metalloproteinase-3 ( MMP-3) , tissue *inhibitor* of metalloproteinase-1 ( ) , fibronectin (FN) , [connective tissue growth factor (CTGF)] and alpha-smooth muscle actin ( alpha-SMA ) were determined semi-quantitatively by immunohistochemistry on the 14th day . Negative_regulation CTGF TIMP1 17038489 1692775 After a 12-wk-long experimental period , the Achilles tendon was tested mechanically and the cross-sectional area , the soleus and gastrocnemius muscle mass , and mRNA concentration of collagen I , collagen III , tissue *inhibitor* of metalloproteinase-1 ( ) , transforming growth factor-beta , [connective tissue growth factor] , and matrix metalloproteinase-2 was determined . Negative_regulation CTGF TIMP1 19234054 2062078 Pulmonary artery matrix metalloproteinase-13 (MMP-13) , tissue *inhibitor* of metalloproteinase-1 ( ) , and [connective tissue growth factor (CTGF)] were evaluated by immunohistochemistry . Negative_regulation CTGF TIMP1 19375424 2106400 HSCs from Sprague-Dawley rats were exposed to leptin and expression of collagen-I , tissue *inhibitor* of matrix metalloproteinases-1 ( ) , transforming growth factor beta1 ( TGF-beta1 ) , and [connective tissue growth factor] ( CTGF/CCN2 ) was assessed . Negative_regulation CTGF TIMP1 20819546 2318389 This study aimed to establish an in vitro cell culture model of rhesus monkey lumbar intervertebral discs and to investigate the effect of combined [connective tissue growth factor (CTGF)] and tissue *inhibitor* of metalloprotease-1 ( ) expression mediated by adeno associated virus ( AAV ) on collagen type II and proteoglycan levels . Negative_regulation CTGF TIMP1 21464546 2412906 Tissue hydroxyproline , the mRNA expression of Collagen I , Collagen III , transforming growth factor-beta 1 ( TGF-ß1 ) , [connective tissue growth factor (CTGF)] , a-smooth muscle actin ( a-SMA ) , matrix metalloproteinase-9 (MMP-9) and tissue *inhibitor* of metalloproteinase-1 ( ) of rat liver was detected . Negative_regulation CTGF TIMP1 21475835 2185152 We analyzed the intrahepatic messenger RNA ( mRNA ) expression of several ECM metabolism related genes : transforming growth factor ß1 ( TGF-ß1 ) , [connective tissue growth factor (CTGF)] , procollagen-a1 ( collagen-I ) , matrix metalloproteinase (MMP)-2 , MMP-13 and tissue *inhibitor* of metalloproteinases ( ) -1 on days 10 , 21 and 42 after bile duct ligation ( BDL ) . Negative_regulation CTGF TIMP1 23207149 2705326 FQ-PCR analysis showed that CTGFshRNA and specifically *inhibited* the expression of [CTGF] , TIMP-1 , and PC I mRNA in activated HSC-T6 cells . Negative_regulation CTGF TIMP1 24188024 2910236 Twelve selected biomarkers previously associated to airway remodeling such as [connective tissue growth factor (CTGF)] , fibroblast growth factor (FGF)-2 , matrix metalloproteinase (MMP)-1 , MMP-2 , MMP-3 , MMP-7 , MMP-8 , MMP-9 , MMP-12 , MMP-13 , procollagen type 1 and tissue *inhibitor* of metalloproteinase ( ) -1 were measured in sputum samples using ELISA or Luminex technology . Negative_regulation CTGF TIMP2 21591863 2430672 To investigate the aqueous humor levels of [connective tissue growth factor (CTGF)] , matrix metalloprotinease-2 (MMP-2) , and tissue *inhibitor* of matrix metalloprotinease-2 ( ) in human eyes with exfoliative glaucoma , primary open-angle glaucoma , and senile cataract patients . Negative_regulation CTGF TNF 16936247 1673103 TGF-beta1 induced [CTGF] expression can be *blocked* by . Negative_regulation CTGF TNF 19385047 2069259 *suppressed* TGF-beta induced [CTGF] expression by switching the binding preference of p300 from Smad4 to p65 . Negative_regulation CTGF TNF 19922639 2176242 In addition , tumour necrosis factor (TNF)alpha can induce the CTGF production from synovial fibroblasts even though can oppositely *inhibit* the production of [CTGF] from chondrocytes . Negative_regulation CTGF TNF 23029004 2680745 IFN-? and synergize to *inhibit* [CTGF] expression in human lung endothelial cells . Negative_regulation CTGF TNF 23029004 2680746 IFN-? and *down-regulated* [CTGF] in human LEC at the promoter- , transcriptional- and translational-level in a dose- and time dependent manner . Negative_regulation CTGF VEGFA 15703462 1382798 At high concentration of TGF-beta , production predominates and [CTGF] production was *inhibited* . Negative_regulation CTGF WNT1 20299474 2281620 Dickkopf-1 , a specific Wnt antagonist , also attenuated the high-glucose induced CTGF overexpression , indicating a *role* of signaling in [CTGF] overexpression in diabetes . Negative_regulation CTGF WNT1 21473864 2428153 The indirect upregulation of [CTGF] expression by Dll1 is likely *due* to the ability of Dll1icd to increase signaling , a pathway that targets CTGF . Negative_regulation CTGF WNT11 20299474 2281621 Dickkopf-1 , a specific Wnt antagonist , also attenuated the high-glucose induced CTGF overexpression , indicating a *role* of signaling in [CTGF] overexpression in diabetes . Negative_regulation CTGF WNT11 21473864 2428154 The indirect upregulation of [CTGF] expression by Dll1 is likely *due* to the ability of Dll1icd to increase signaling , a pathway that targets CTGF . Negative_regulation CTGF WNT16 20299474 2281626 Dickkopf-1 , a specific Wnt antagonist , also attenuated the high-glucose induced CTGF overexpression , indicating a *role* of signaling in [CTGF] overexpression in diabetes . Negative_regulation CTGF WNT16 21473864 2428159 The indirect upregulation of [CTGF] expression by Dll1 is likely *due* to the ability of Dll1icd to increase signaling , a pathway that targets CTGF . Negative_regulation CTGF WNT2 20299474 2281622 Dickkopf-1 , a specific Wnt antagonist , also attenuated the high-glucose induced CTGF overexpression , indicating a *role* of signaling in [CTGF] overexpression in diabetes . Negative_regulation CTGF WNT2 21473864 2428155 The indirect upregulation of [CTGF] expression by Dll1 is likely *due* to the ability of Dll1icd to increase signaling , a pathway that targets CTGF . Negative_regulation CTGF WNT3 20299474 2281623 Dickkopf-1 , a specific Wnt antagonist , also attenuated the high-glucose induced CTGF overexpression , indicating a *role* of signaling in [CTGF] overexpression in diabetes . Negative_regulation CTGF WNT3 21473864 2428156 The indirect upregulation of [CTGF] expression by Dll1 is likely *due* to the ability of Dll1icd to increase signaling , a pathway that targets CTGF . Negative_regulation CTGF WNT3A 20299474 2281649 Further , SERPINA3K also attenuated the *induced* activation of the canonical Wnt pathway and the overexpression of [CTGF] . Negative_regulation CTGF WNT4 20299474 2281624 Dickkopf-1 , a specific Wnt antagonist , also attenuated the high-glucose induced CTGF overexpression , indicating a *role* of signaling in [CTGF] overexpression in diabetes . Negative_regulation CTGF WNT4 21473864 2428157 The indirect upregulation of [CTGF] expression by Dll1 is likely *due* to the ability of Dll1icd to increase signaling , a pathway that targets CTGF . Negative_regulation CTGF WNT6 20299474 2281625 Dickkopf-1 , a specific Wnt antagonist , also attenuated the high-glucose induced CTGF overexpression , indicating a *role* of signaling in [CTGF] overexpression in diabetes . Negative_regulation CTGF WNT6 21473864 2428158 The indirect upregulation of [CTGF] expression by Dll1 is likely *due* to the ability of Dll1icd to increase signaling , a pathway that targets CTGF . Negative_regulation CTGF WWTR1 23959471 2920845 In conclusion , promotes malignant cell growth and *inhibits* apoptosis by cyclin A and [CTGF] regulation . Negative_regulation CTH SRGN 16796902 1579053 shunt + PPG group undergoing abdominal aorta-inferior vena cava puncture so as to establish model of left-to-right shunt and then intraperitoneal injection of , an *inhibitor* of [cystathionine-gamma-lyase] : sham group undergoing sham operation ; Negative_regulation CTH SRGN 17346888 1797695 L-Cysteine , an endogenous source for H ( 2 ) S , given i.pl. , also elicited hyperalgesia , an effect being abolished by and beta-cyanoalanine ( BCA ) , *inhibitors* of [cystathionine-gamma-lyase] , a H(2)S synthesizing enzyme . Negative_regulation CTH SRGN 17437046 1729075 ( 6 ) APD in the normal papillary muscles was increased by DL-propargylglycine ( , an *inhibitor* of [cystathionine gamma-lyase] , 200 micromol/L ) . Negative_regulation CTH SRGN 2033464 159630 Because *inhibits* [gamma-cystathionase] specifically , rats infused with PPG as part of a TPN regimen were evaluated as a potential model . Negative_regulation CTH SRGN 9291354 452728 However , injection of , an *inhibitor* of [cystathionase] , decreased the zinc induced MT synthesis in the tumors and also decreased the tumor weight after exposure to X radiation . Negative_regulation CTNNB1 AXIN2 10023673 590681 *prevents* Wnt-3a induced accumulation of [beta-catenin] . Negative_regulation CTNNB1 AXIN2 10722668 677118 Down-regulation of [beta-catenin] by the colorectal tumor suppressor APC *requires* association with and beta-catenin . Negative_regulation CTNNB1 AXIN2 10906131 743642 *down-regulated* [beta-catenin] in SW480 cells , but not Axin ( delta ) ( beta)(-catenin ) . Negative_regulation CTNNB1 AXIN2 10906131 743644 In L cells where APC is intact , ( delta ) ( beta)(-catenin ) *inhibited* Wnt dependent accumulation of [beta-catenin] but not Axin- ( 298-832 ) ( delta ) ( beta)(-catenin ) in which the APC- and beta-catenin binding sites are deleted . Negative_regulation CTNNB1 AXIN2 11970895 933220 Overexpression of Dapper increases and GSK-3 in this complex , *resulting* in decreased soluble beta-catenin and decreased activation of [beta-catenin-responsive] genes . Negative_regulation CTNNB1 AXIN2 12192039 980768 This interaction inhibited *mediated* downregulation of free levels of cytosolic [beta-catenin] . Negative_regulation CTNNB1 AXIN2 15188427 1256672 Biochemical analysis revealed that such an increase in [betacatenin] was *due* to the disruption of complexes promoted by the increased expression of Frat , the mouse homologue of GSK3betabinding protein ( GBP ) , in epidermis , precluding the degradation of betacatenin . Negative_regulation CTNNB1 AXIN2 16303557 1485452 We conclude that rapid disruption of interactions in response to Wnt *leads* to the initial stabilization of [beta-catenin] and that Galpha ( o ) and Galpha ( q ) signaling contributes to Wnt mediated GSK3beta/Axin disruption and the ultimate stabilization of beta-catenin . Negative_regulation CTNNB1 AXIN2 18372914 1938174 In addition , a high level of p53 downregulates the [beta-catenin] expression , but this effect is *attenuated* by non-functional or betaTrCP in lung cancer . Negative_regulation CTNNB1 AXIN2 19131506 2037542 Overexpression of , an *inhibitor* of [beta-catenin] , also reduces GnRH stimulation of TOPflash . Negative_regulation CTNNB1 AXIN2 20010817 2191341 Wnt7a and active beta-catenin promote neural stem cell self-renewal , whereas the deletion of Wnt7a or the lentiviral transduction of , a [beta-catenin] *inhibitor* , led to decreased cell proliferation in adult neurogenic areas . Negative_regulation CTNNB1 AXIN2 9501208 491101 In mammalian cells , *inhibits* Wnt-1 stimulation of [beta-catenin/lymphoid] enhancer factor 1-dependent transcription . Negative_regulation CTNNB1 CCND1 15111320 1241141 [Beta-catenin] simultaneously *induces* activation of the p53-p21WAF1 pathway and overexpression of during squamous differentiation of endometrial carcinoma cells . Negative_regulation CTNNB1 CCND1 15111320 1241144 These findings indicate that in Em Cas , nuclear [beta-catenin] can simultaneously *induce* activation of the p53-p21WAF1 pathway and overexpression of , leading to suppression of cell proliferation or induction of cell senescence . Negative_regulation CTNNB1 CCND1 17638904 1770893 Treatment of DU145 human prostate cancer cells with 10 and 20 micromol/L apigenin also increased protein levels of E-cadherin by 27 % to 74 % , *inhibited* nuclear translocation of [beta-catenin] and its retention in the cytoplasm , and decreased c-Myc and levels , an effect similar to the exposure of cells to beta-catenin small interfering RNA . Negative_regulation CTNNB1 CCND1 18048388 1861132 Ectopic expression of Dkk3 in lung cancer cells with Dkk3 hypermethylation induced apoptosis and *inhibited* TCF-4 activity as well as nuclear accumulation of [beta-catenin] and expression of TCF-4 targets c-Myc and . Negative_regulation CTNNB1 CCND1 19089909 2031002 It also inhibited the transcriptional activities of [beta-catenin/TCF4] , and USF2 , and *inhibited* the expression of endogenous and TGFbeta2 . Negative_regulation CTNNB1 FOXO1 18250171 1884711 Interaction of with beta-catenin *inhibits* [beta-catenin/T] cell factor activity . Negative_regulation CTNNB1 FOXO1 19268509 2135406 A prominent feature of ROS induced FOXO activation is ROS induced binding of beta-catenin to FOXO [[6 ] M.A. Essers , L.M. de Vries-Smits , N. Barker , P.E. Polderman , B.M. Burgering , H.C. Korswagen , Functional interaction between beta-catenin and FOXO in oxidative stress signaling , Science ( New York , NY ) 308 ( 2005 ) 1181-1184 , [ 7 ] M. Almeida , L. Han , M. Martin-Millan , C.A. O'Brien , S.C. Manolagas , Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription , J. Biol. Chem. 282 ( 2007 ) 27298-27305 , [ 8 ] D. Hoogeboom , M.A. Essers , P.E. Polderman , E. Voets , L.M. Smits , B.M. Burgering , Interaction of with beta-catenin *inhibits* [beta-catenin/T] cell factor activity , J. Biol. Chem. 283 ( 2008 ) 9224-9230 ] . Negative_regulation CTNNB1 HBEGF 12057867 952231 In contrast , epidermal growth factor (EGF) or ( HB-EGF ) *induces* the epithelial-like to fibroblastoid conversion of A549 and H322 cell lines , slightly reduces the expression of E-cadherin and [beta-catenin] , but not alpha- and gamma-catenins , and stimulates cell motility . Negative_regulation CTNNB1 MAP2K6 20089873 2258673 In addition , the VEGF induced transcriptional *activation* of [beta-catenin] and uPAR expression were blocked by PEDF and by inhibitors of p38 and . Negative_regulation CTNNB1 NES 15051498 1229562 In addition , mutations in NES1 , but not , *reduced* binding of alpha-catenin to [beta-catenin] and impaired the ability of alpha-catenin to repress beta-catenin/Tcf dependent transcription . Negative_regulation CTNNB1 NES 15051498 1229563 Therefore , is *required* both for repression of [beta-catenin] signaling and for nuclear export , while NES2 is required only for nuclear export . Negative_regulation CTNNB1 PECAM1 10462517 640037 ( 3 ) can *prevent* [beta-catenin] nuclear translocation in transfected SW480 colon carcinoma cells . Negative_regulation CTNNB1 S100A7 18223693 1919127 Furthermore , we demonstrated that is associated with the beta-catenin complex , and *inhibits* [beta-catenin] signaling by targeting beta-catenin degradation via a noncanonical mechanism that is independent of GSK3beta mediated phosphorylation . Negative_regulation CTNNB1 TNF 12503700 1026844 In human bronchial epithelial cells the authors have shown that *induced* a significant decrease of E-cadherin and [beta-catenin] expression . Negative_regulation CTNNB1 TP63 14989490 1182869 Briefly , in vitro studies using squamous cell carcinoma cell lines have suggested that may *block* the phosphorylation of [beta-catenin] , leading to its nuclear accumulation and triggering beta-catenin-responsive transcription of genes related to proliferation and oncogenic biological behavior . Negative_regulation CTNNB1 WIF1 19307728 2056229 In vitro , *suppressed* [beta-catenin] levels in human osteosarcoma cell lines , induced differentiation of human and mouse primary osteoblasts , and suppressed the growth of mouse and human osteosarcoma cell lines . Negative_regulation CTNND1 CAPN8 21571907 2458938 Furthermore , pharmacological inhibition or depletion of calpain-1 with a specific siRNA *prevented* [p120-catenin] loss and subsequent stretch induced gap formation . Negative_regulation CTNND1 EPHB2 12456636 1021295 FRNK expression disrupted the formation of a v-Src-FAK signaling complex , *inhibited* [p130Cas] tyrosine phosphorylation , and attenuated v-Src stimulated and JNK kinase activation . Negative_regulation CTR9 ARSA 6711391 37374 These studies suggest that regulates PAF availability unrelated to its effect on cyclooxygenase and that MC membrane products directly *inhibit* [PAF] activity from rat PLC . Negative_regulation CTR9 ARSA 8430224 212740 Since acetylsalicylic acid (ASA) is an accepted therapeutic alternative in these patients , we sought to determine if would *attenuate* endothelial cell [PAF] production resulting from ACA exposure . Negative_regulation CTR9 CD14 7541418 310476 The soluble form of ( sCD14 ) , when added to MO stimulated with LBP-LPS complexes , *inhibited* the synthesis of [PAF] possibly by competing with mCD14 . Negative_regulation CTR9 IL1B 1519663 196900 Stimulation of isolated mouse alveolar macrophages with recombinant murine or IL-1 alpha *resulted* in rapid , dose dependent , and cell concentration dependent increases in [PAF] secretion . Negative_regulation CTR9 TNF 9403541 469609 Furthermore , inhibiting [PAF] production with AACOCF3 , or manoalide , also *inhibited* LPS induced Mphi mRNA expression . Negative_regulation CTSB CST6 12798398 1100913 , an endogenous [cathepsin B] *inhibitor* , was expressed 40-fold higher in the metastatic versus the primary tumor cell line . Negative_regulation CTSB CST6 15530858 1332864 , released from the NPs , effectively *inhibited* [cathepsin B] activity , as detected by degradation of specific Z-Arg-Arg cresyl violet substrate . Negative_regulation CTSB CST6 17048522 1635976 delivered into MCF-10A neoT cells by PLGA NPs effectively *inhibited* intracellular proteolytic activity of [cathepsin B] , as detected by specific fluorogenic substrate Z-Arg2 cresyl violet . Negative_regulation CTSB CST6 17048522 1635986 On the contrary , free in solution did not internalise into the cells and *inhibit* [cathepsin B] . Negative_regulation CTSB CST6 17381726 1715493 We demonstrated that palmitoylated rapidly internalized into the cell and *caused* a complete loss of [cathepsin B] activity . Negative_regulation CTSB CST6 18702630 1974133 The experiments showed that acylated quickly internalized into the cells and effectively *inhibited* [cathepsin B] . Negative_regulation CTSB CST6 18754876 1956438 Over-expression of *inhibited* the intracellular activity of [cathepsin B] , which is one of the putative substrates of CST6 proteinase inhibitor and can intracellularly function as a pro-apoptotic factor . Negative_regulation CTSB CST6 21172403 2396392 Crude Austrelaps superbus ( Australian lowland copperhead ) snake venom inhibited papain , and a recombinant form of A. superbus *inhibited* cathepsin L ? papain [> cathepsin B] , with no inhibition observed for calpain or legumain . Negative_regulation CTSB CST6 9276465 450711 Surprisingly , however , [cathepsin B] was *inhibited* 15-fold more strongly by quail ( Ki = 47 pM ; k ( on ) = 19x10 ( 7 ) M ( -1 ) s ( -1 ) ; k ( off ) = 9x10 ( -4 ) s ( -1 ) ) than by chicken cystatin ( Ki = 784 pM ; k ( on ) = 2.9x10 ( 7 ) M ( -1 ) s ( -1 ) ; k ( off ) = 24x10 ( -4 ) s ( -1 ) ) . Negative_regulation CTSB PLAU 17172424 1662298 RNA interference mediated simultaneous down-regulation of receptor and [cathepsin B] *induces* caspase-8 mediated apoptosis in SNB19 human glioma cells . Negative_regulation CTSB TNFSF10 17431792 1748959 [Cathepsin B] activity in U2OS cells was significantly activated shortly after exposure to TRAIL , and the cathepsin B inhibitor , CA074Me , *inhibited* both and anti-DR5 mediated apoptosis and delayed the cleavage of Bid . Negative_regulation CTSC OLFM4 22844115 2646619 *inhibits* [cathepsin C-mediated] protease activities , thereby modulating neutrophil killing of Staphylococcus aureus and Escherichia coli in mice . Negative_regulation CTSC OLFM4 22844115 2646621 We demonstrated that *inhibited* [cathepsin C] activity in vitro and in vivo . Negative_regulation CTSD OLFM4 21470957 2448240 Mechanistic studies revealed that OLFM4 may exhibit its anticancer effects through regulating cell autophagy by targeting cathepsin D , as *reduced* [cathepsin D] protein levels and enzymatic activity and attenuated cathepsin D-induced cancer cell proliferation . Negative_regulation CTSD TGM2 21960143 2718852 Binding of to CTSD *resulted* in the depletion of [CTSD] via cross linking in vitro as well as in MEFs , leading to decreased levels of apoptosis . Negative_regulation CTSF CST6 15255182 1272023 [Cathepsin F] was rapidly and tightly *inhibited* by cystatin C , chicken and equistatin with Ki values in the subnanomolar range ( 0.03-0.47 nM ) , whereas L-kininogen was a less strong inhibitor of the enzyme ( Ki=4.7 nM ) . Negative_regulation CTSH CST6 14621998 1168600 Recombinant human [cathepsin H] was *inhibited* by chicken , stefin A , and stefin B with the K ( i ) values in the range of 0.05-0.1 nM , which is slightly tighter than the inhibition of purified cathepsin H by the same inhibitors . Negative_regulation CTSK CST6 10951198 723606 [Cathepsin X] was *inhibited* by stefin A , cystatin C and chicken ( Ki = 1.7-15.0 nM ) , but poorly or not at all by stefin B ( Ki > 250 nM ) and L-kininogen , respectively . Negative_regulation CTSL CST6 16565075 1568359 We report that human cathepsin V (CTSV) and human [cathepsin L (CTSL)] are strongly *inhibited* by human . Negative_regulation CTSL FOXO1 22102632 2557435 Expression of DN *inhibited* the increased mRNA levels of atrogin-1 , MuRF1 , [cathepsin L] , and/or Bnip3 and inhibited muscle fiber atrophy during cancer cachexia and sepsis . Negative_regulation CTSS CST6 15161240 1252803 According to sodium dodecyl sulfate-polyacrylamide gel electrophoresis and enzymic activity analyses , cross linking of mackerel and hairtail myosin heavy chain and low molecular mass compounds and formation of epsilon- ( gamma-glutamyl ) lysine cross-links were observed on samples with MTGase , while the recombinant could effectively *inhibit* the [cathepsins] and subsequently prevent degradation of proteins during setting . Negative_regulation CTSS CST6 3555467 68267 Our laboratory has been involved in the study of the role of lysosomal proteinases , namely , [cathepsins] B , H and L and the endogenous cysteine proteinase *inhibitor* , , during muscle differentiation in vitro . Negative_regulation CTSV CST6 16565075 1568360 We report that human [cathepsin V (CTSV)] and human cathepsin L (CTSL) are strongly *inhibited* by human . Negative_regulation CUL1 FGD3 18363964 1887900 Here we show that , which was identified as a homologue of FGD1 but has been poorly characterized , has conserved the same motif and is *down-regulated* similarly by [SCF] ( FWD1/beta-TrCP ) . Negative_regulation CUL4A EPHB2 18332868 1925098 Consistently , VprBP depletion abolished the in vivo interaction of Merlin and [Roc1-Cullin4A-DDB1] , which resulted in Merlin stabilization and *inhibited* and Rac activation . Negative_regulation CUX1 TNF 10665999 665315 In confluent SMCs , the synthesis of [CDP] was more strongly *inhibited* by than that of NCP . Negative_regulation CX3CL1 CTGF 16408113 1513388 The present studies investigate the regulatory *role* of in the production of [fractalkine] , monocyte chemoattractant protein-1 ( MCP-1 ) , and RANTES ( regulated upon activation , normal T cell expressed and secreted ) in cultured mesangial cells of rats , and the modulatory effects of lipoxin A ( 4 ) ( LXA ( 4 ) ) on actions of CTGF . Negative_regulation CX3CL1 S100B 19961838 2199377 Albumin activated ERK1/2 , p38 MAPK and JNK signaling pathways in astrocytes , and *induced* the production of interleukin (IL)-1beta , inducible nitric oxide (NO) synthase , the NO metabolite nitrite , and the chemokine [CX3CL1] while reducing the level of . Negative_regulation CX3CL1 TNF 15111313 1241123 Tumor necrosis factor-alpha *induces* [fractalkine] expression preferentially in arterial endothelial cells and mithramycin A suppresses induced fractalkine expression . Negative_regulation CX3CL1 TNF 18230685 1911285 We show , in lung A549 epithelial cells , that the and IFNgamma synergistically induced protein release and mRNA expression of [CX(3)CL1] is *inhibited* by dexamethasone , without interfering with cytokine induced nuclear translocation of NF-kappaB , and by an inhibitor of IkappaB kinase 2 , AS602868 . Negative_regulation CXCL1 F2R 7482442 335398 These results suggest that catalytic activation of by thrombin *results* in GRO [alpha/MGSA] production , at least in part , via a pathway involving PKC in HUVEC . Negative_regulation CXCL1 TNF 19353522 2064843 C/EBPbeta knockdown also inhibited the synergistic expression of [CXCL1] , inducible nitric oxide synthase , and CCL5 in *response* to concomitant IFNgamma and . Negative_regulation CXCL1 TNF 22976954 2693595 The synergistic effect of and IL-17A on astrocytes *resulted* in enhanced secretion of [CXCL-1] , a neutrophil chemoattractant . Negative_regulation CXCL10 CCL17 12446452 1084497 Finally , adenosine augmented the release of the chemokine and *inhibited* [CXCL10] production by mDCs . Negative_regulation CXCL10 EPHB2 17617806 1769738 The suppressive effect on MDC and [IP-10] may , at least in part , *involve* the down-regulation of LPS induced p38 and expression . Negative_regulation CXCL10 GLP1R 21595283 2430747 Furthermore , mediated signals might *suppress* the expression of chemokine ligand [CXCL10] which binds to newly identified receptor TLR4 ( Toll-like receptor 4 ) , and impairs beta cell function and viability in diabetes . Negative_regulation CXCL10 TLR7 17170125 1717066 Blockade of IFN-alpha/beta *inhibits* [IP-10] production by agonist activated regulatory DCs . Negative_regulation CXCL10 TNF 14597565 1187427 induced CXCL10 expression in hASM was dependent on NFkappaB activation , and a salicylanilide NFkappaB inhibitor *blocked* the [CXCL10] expression . Negative_regulation CXCL10 TNF 22022590 2499098 Anti-IFN? antibodies and soluble receptor completely *blocked* [CXCL10] upregulation . Negative_regulation CXCL10 TNF 24219422 2865094 Drug treatments significantly inhibited secretion of [CXCL10] in mock infected , but not RV-infected , BE cells , and *inhibited* secretion of under both conditions . Negative_regulation CXCL11 MUC16 16466101 1523345 We studied the *role* of cytokeratin ( CK ) and expression in differentiating [ITAC] , metastatic adenocarcinoma of intestinal origin , and non-intestinal-type sinonasal adenocarcinoma ( non-ITAC ) . Negative_regulation CXCL12 ANGPT1 22558265 2591214 Overexpression of resulted in a significant increase in CXCR-4/SDF-1a expression and *promoted* CD133 ( + ) /c-kit ( + ) , CD133 ( + ) /CXCR-4 ( + ) and CD133 ( + ) [/SDF-1a] ( + ) cell recruitment into ischemic hearts . Negative_regulation CXCL12 TNF 15075355 1265791 In vivo , and IFN-gamma *inhibit* growth factor induced angiogenesis and [SDF-1] expression in endothelial cells . Negative_regulation CXCL12 TNF 18371213 1925415 *reduced* [SDF-1] expression by ST2 cells . Negative_regulation CXCL12 TNF 18371213 1925416 Systemically elevated levels *inhibit* bone marrow stromal cell production of [SDF-1] and increase the release of bone marrow OCPs to the peripheral blood . Negative_regulation CXCL12 TNF 20923761 2347475 We show here that *inhibits* both basal and LIGHT induced [CXCL12] expression . Negative_regulation CXCL12 TNF 20923761 2347479 In contrast , ectopic RelB expression recapitulated the effects of on NC signaling and *inhibited* basal and LIGHT induced [CXCL12] expression by HUVEC . Negative_regulation CXCL13 TNF 15050303 1229342 *reduced* [CXCL13] production only in BMSC from OA patients . Negative_regulation CXCL2 EPHB2 20477948 2288587 In addition , protein kinase C inhibitors suppressed ATP induced and JNK activation , and also *inhibited* ATP induced [CXCL2] expression in microglia . Negative_regulation CXCR1 TLR7 15819701 1393495 [CXCR1] and CXCR2 were *down-regulated* by engagement . Negative_regulation CXCR1 TNF 11531949 853938 Down-regulation of [CXCR1] and CXCR2 expression on human neutrophils upon activation of whole blood by S. aureus is *mediated* by . Negative_regulation CXCR1 TNF 11531949 853940 We further showed that *induced* decrease of [CXCR1] and CXCR2 expression was associated with lower IL-8 binding and lower CXCR1 and CXCR2 mRNA levels , and was abrogated by protease inhibitors . Negative_regulation CXCR1 TNF 11531949 853942 We suggest that during septicemia , S. aureus may inhibit neutrophil responsiveness to IL-8 and other CXC chemokines via *mediated* down-regulation of [CXCR1] and CXCR2 . Negative_regulation CXCR2 TLR7 15819701 1393505 CXCR1 and [CXCR2] were *down-regulated* by engagement . Negative_regulation CXCR2 TLR7 22661085 2615428 First , the anti-fungal effect occurred due to the rapid and massive recruitment of neutrophils to the site of infection as a result of the release of CXCR2 chemokines by peritoneal macrophages and by reversal of the *induced* reduction of [CXCR2] expression in neutrophils during IL-33 priming . Negative_regulation CXCR2 TNF 10950785 723472 [CXCR2] down-regulation *induced* by LPS or in vitro was abrogated by a p38 mitogen activated protein kinase (MAPK) inhibitor . Negative_regulation CXCR2 TNF 11531949 853939 Down-regulation of CXCR1 and [CXCR2] expression on human neutrophils upon activation of whole blood by S. aureus is *mediated* by . Negative_regulation CXCR2 TNF 11531949 853941 We further showed that *induced* decrease of CXCR1 and [CXCR2] expression was associated with lower IL-8 binding and lower CXCR1 and CXCR2 mRNA levels , and was abrogated by protease inhibitors . Negative_regulation CXCR2 TNF 11531949 853943 We suggest that during septicemia , S. aureus may inhibit neutrophil responsiveness to IL-8 and other CXC chemokines via *mediated* down-regulation of CXCR1 and [CXCR2] . Negative_regulation CXCR3 TNF 20579746 2290584 *dependent* regulation of [CXCR3] expression modulates neuronal survival during West Nile virus encephalitis . Negative_regulation CXCR4 ANGPT1 22558265 2591215 Overexpression of resulted in a significant increase in CXCR-4/SDF-1a expression and *promoted* CD133 ( + ) /c-kit ( + ) , CD133 ( + ) [/CXCR-4] ( + ) and CD133 ( + ) /SDF-1a ( + ) cell recruitment into ischemic hearts . Negative_regulation CXCR4 EPHB2 17179222 1717269 Specific inhibition of during CB DC maturation *enhanced* LPS induced up-regulation of CCR7 and [CXCR4] on CB DCs and their chemotaxis toward CCL19 and CXCL12 , to a level similar to that of mature AB DCs . Negative_regulation CXCR4 SLC38A3 18768385 1985709 This study compares the interactions of three structurally diverse small-molecule CXCR4 inhibitors with the receptor and is the first report of the molecular interactions of the nonmacrocyclic [CXCR4] *inhibitor* ( ) -N'- ( 5,6,7,8-tetrahydroquinolin-8-yl ) butene-1,4-diamine ( AMD11070 ) . Negative_regulation CXCR4 TNF 10679062 668597 Stimulation of mature DCs with TGF-beta 1 also enhanced *induced* down-regulation of the expressions of CCR-1 , CCR-3 , CCR-5 , CCR-6 , and [CXCR-4] , and chemotaxis to their respective ligands , while this stimulation suppressed TNF-alpha induced expression of CCR-7 and chemotactic migratory ability to MIP-3 beta . Negative_regulation CXCR4 TNF 11023494 738297 LPS stimulated up-regulation of [CXCR4] and CCR5 in vitro was *inhibited* by and anti-IFN gamma . Negative_regulation CXCR4 TNF 11146046 780344 *mediated* decrease of [CXCR4] mRNA accumulation resulted in decreased CXCR4 protein expression . Negative_regulation CXCR4 TNF 12555203 1051613 Expression of chemokines and their receptors in human and simian astrocytes : evidence for a central *role* of and IFN gamma in [CXCR4] and CCR5 modulation . Negative_regulation CXCR4 TNF 16288025 1481186 stimulation activated components of the nuclear factor kappaB pathway , and overexpression of the inhibitor of kappaB also *reduced* [CXCR4] expression . Negative_regulation CXCR4 TNFSF10 23647548 2805294 These results were confirmed in a human breast cancer xenograft mouse model , suggesting that significantly enhanced miR-146a expression and *suppressed* [CXCR4] expression , indicating that TRAIL induced miR-146a up-regulation is negatively associated with CXCR4 expression . Negative_regulation CXCR6 IL1B 19438592 2078065 On the other hand , and interferon-gamma *inhibited* [CXCR6] expression on TNF-alpha treated HGF . Negative_regulation CYBA ARSA 1685923 175338 Superoxide anion production requires translocation of a [cytochrome b-245] and this translocation was *reduced* by sulphasalazine ( P less than 0.01 ) but not by <5-ASA> or sulphapyridine . Negative_regulation CYBB ARSA 15326075 1290595 SIN-1 , NCX 4016 , and NCX 4050 but not alone *inhibited* the formation of O2*- and expression of [gp91(phox)] . Negative_regulation CYBB ARSA 1685923 175339 Superoxide anion production requires translocation of a [cytochrome b-245] and this translocation was *reduced* by sulphasalazine ( P less than 0.01 ) but not by <5-ASA> or sulphapyridine . Negative_regulation CYBB TLR7 23386616 2754974 In this study , we investigated the *role* of in [Nox2] expression in spinal cord microglia after peripheral nerve injury . Negative_regulation CYBB TNF 12016268 942388 Stimulation of HPAE cells with *resulted* in the phosphorylation of p47(phox) and its association with [gp91(phox)] . Negative_regulation CYBB TNF 19450605 2096913 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated [gp91(phox)-NADPH] oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 MAPK and *inhibited* cardiac expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation CYCS CAPN8 18468506 1921539 We found that inhibition of *increased* oridonin induced Bax activation , [cytochrome c] release and PARP cleavage , indicating that calpain plays an anti-apoptotic role in oridonin induced L929 cell apoptosis . Negative_regulation CYCS CLU 17416353 1728596 expression also restored partially the mitochondrial membrane potential and *prevented* the release of [cytochrome-c] from mitochondria into cytoplasma . Negative_regulation CYCS CLU 17689225 1788324 The hyper expressed form of localizes to mitochondria , *inhibits* [cytochrome c] release , and is inhibited by the proteasome . Negative_regulation CYCS EPHB2 11854398 913744 Concomitantly , we have also demonstrated that recombinant Mos , MEK , and are *sufficient* to block [cytochrome c-dependent] caspase activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CYCS EPHB2 20046096 2200676 expression *results* in mitochondrial depolarization and translocation of [cytochrome c] from the mitochondria to the cytosol . Negative_regulation CYCS FAS 10647997 662007 By contrast , stimulation alone *resulted* in neither [cytochrome c] release nor caspase 9 activation at 3 h , and the increase in the DEVD cleavage activity and apoptosis became evident at later time points . Negative_regulation CYCS FAS 11980895 954076 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of MMP and [cytochrome c] release . Negative_regulation CYCS FAS 22516057 2700727 Furthermore , dioscin decreased the protein expressions of , increased Bcl-2/Bax ratio , *inhibited* the release of [cytochrome c] from mitochondrion to cytosol and attenuated CCl ( 4 ) -induced caspase-3 and -8 activities . Negative_regulation CYCS IFI27 20724915 2313057 Concurrent with the late G1 arrest , we observed an overexpression of along with a decreased expression of p21 , cyclin dependent kinase 1 , cyclin dependent kinase 4 , and cyclin D. Clotrimazole *induced* the translocation of mitochondrial bound hexokinase II to the cytoplasm and the release of [cytochrome c] into the cytoplasm . Negative_regulation CYCS MAP2K6 11854398 913750 Concomitantly , we have also demonstrated that recombinant Mos , , and ERK are *sufficient* to block [cytochrome c-dependent] caspase activation in purified Xenopus cytosol , which lacks both transcription and translation . Negative_regulation CYCS MMP28 11067917 747093 Overexpression of B cell lymphoma gene 2 (Bcl-2) *inhibited* TRAIL induced release of [cytochrome c] , changes in , and apoptosis . Negative_regulation CYCS MMP28 23516491 2761578 Reactive oxygen species ( ROS ) generation , activation of mitochondrial permeability transition pores ( MPTPs ) and loss of mitochondrial were observed very early during apoptosis and were *followed* subsequently by the release of [cytochrome-c] from the mitochondria . Negative_regulation CYCS MMP7 11067917 747108 Overexpression of B cell lymphoma gene 2 (Bcl-2) *inhibited* TRAIL induced release of [cytochrome c] , changes in , and apoptosis . Negative_regulation CYCS MMP7 23516491 2761593 Reactive oxygen species ( ROS ) generation , activation of mitochondrial permeability transition pores ( MPTPs ) and loss of mitochondrial were observed very early during apoptosis and were *followed* subsequently by the release of [cytochrome-c] from the mitochondria . Negative_regulation CYCS PLAT 18199803 1870304 In vitro , inhibited staurosporine or H ( 2 ) O ( 2 ) -induced caspase-3 activation , prevented cellular DNA fragmentation , and *suppressed* the release of [cytochrome C] from mitochondria into the cytosol in a rat interstitial fibroblast cell line ( NRK-49F ) . Negative_regulation CYCS TNF 11300499 802125 This effect of was *mediated* by inhibition of mitochondrial [cytochrome c] release . Negative_regulation CYCS TNF 12202395 983058 CD40 ligation and *prevented* release of [cytochrome c] and activation of caspase-3 , which could not be explained by effects on the expression of Bcl-2 , Bcl-x ( L ) or Bax . Negative_regulation CYCS TNF 12869386 1149973 SP-600125 , a specific inhibitor of JNK activation , prevented [cytochrome c] release from mitochondria , JNK activation , DNA fragmentation , and caspase-9 activation in *response* to . Negative_regulation CYCS TNFSF10 15475369 1319202 Instead , in the presence of DcR3 , engagement *resulted* in an increased activation of caspase-8 , an elevated cleavage of Bid , and enhanced release of Smac and [cytochrome c] from mitochondria to cytosol compared with TRAIL alone . Negative_regulation CYLD PDE4B 23575688 2768172 Here , we show that inhibition of markedly *enhances* upregulation of [CYLD] expression in response to bacteria , thereby suggesting that PDE4B acts as a negative regulator for CYLD . Negative_regulation CYP11A1 IL1B 1874173 165332 *inhibited* hCG stimulated testosterone formation and [P450scc] mRNA expression in a dose dependent manner . Negative_regulation CYP11A1 KLF9 18056793 1861295 Transient transfection of KLF4 , , and KLF13 *suppressed* LDLR/luc , StAR/luc , and [CYP11A/luc] by 80-90 % ( P < 0.001 ) . Negative_regulation CYP11A1 LBP 16730372 1672043 Luciferase reporter gene assays showed that specifically *repressed* transcriptional activation of the human [P450scc] promoter . Negative_regulation CYP11A1 TNF 24570488 2919765 We screened for cytokines that regulated intestinal glucocorticoid synthesis and found that *suppressed* corticosterone secretion and [Cyp11a1] and Cyp11b1 expression in an intestinal crypt epithelial cell line . Negative_regulation CYP11A1 TNF 24570488 2919767 suppressed steroidogenesis by activating the transcription factors c-Jun and nuclear factor ?B ( NF-?B ) , which both interacted with the transcription factor NR5A2 and *repressed* [Cyp11a1] reporter activity . Negative_regulation CYP11A1 TNF 8504748 221284 also *caused* a decrease in [P450scc] and P450c17 mRNA and protein . Negative_regulation CYP11A1 TNF 9397943 291199 *inhibited* both [P450scc] and IGF-I mRNA gene expression . Negative_regulation CYP11A1 TNF 9564825 500759 In contrast , interleukin-1 and murine *reduced* hCG induced [P450scc] mRNA expression without inhibiting StAR mRNA or protein levels . Negative_regulation CYP11B1 TNF 24570488 2919766 We screened for cytokines that regulated intestinal glucocorticoid synthesis and found that *suppressed* corticosterone secretion and Cyp11a1 and [Cyp11b1] expression in an intestinal crypt epithelial cell line . Negative_regulation CYP11B2 MAP2K6 19418629 2075911 In accordance with earlier findings , in H295R cells inhibition *increased* the expression of NR4A1 , NR4A2 and [CYP11B2] genes , however , it decreased the Ang II-induced gene expression levels , suggesting that ERK activation has a role in control of expression of these genes . Negative_regulation CYP11B2 NR2F1 15666827 1350492 Unexpectedly , overexpression of *increased* the [CYP11B2] promoter activity , whereas overexpression of SF-1 repressed it in human adrenocortical H295R cells . Negative_regulation CYP11B2 TNF 8768832 378763 *reduced* ANG II- and potassium induced aldosterone synthesis and [CYP11B2] mRNA levels . Negative_regulation CYP17A1 IL1B 9666341 518584 completely *inhibited* cAMP stimulated testosterone production and [P450c17] mRNA expression . Negative_regulation CYP17A1 MAP2K6 15514033 1359679 Similarly , the inhibitor , PD98059 , *increased* CYP17 mRNA accumulation and [CYP17] promoter activity to levels observed in PCOS cells . Negative_regulation CYP17A1 NR2F1 14765993 1207493 Overexpression of Ubc9 similarly enhances *dependent* repression of the promoter activity of the bovine [CYP17] gene encoding steroid 17alpha-hydroxylase . Negative_regulation CYP17A1 TNF 7628389 316411 To determine whether *inhibits* the cAMP induced expression of the [Cyp17] gene , plasmids containing two different size fragments of the 5'-flanking region of the Cyp17 gene upstream of the chloramphenicol acetyltransferase (CAT) reporter gene were transiently transfected into MA-10 tumor Leydig cells , and the effect of TNF alpha on cAMP induced CAT activity was determined . Negative_regulation CYP19A1 IL1B 1646737 157920 *inhibited* FSH stimulated [aromatase] activity in a dose dependent manner while IL-1 alpha had no significant effect . Negative_regulation CYP19A1 SLCO2A1 21212407 2386313 Silencing of in preadipocytes increased PGE ( 2 ) levels in the extracellular medium , thereby stimulating the cAMP ? PKA pathway *resulting* in enhanced interaction between pCREB , p300 , and the [CYP19] I.3/II promoter . Negative_regulation CYP19A1 SLCO2A1 21212407 2386316 Overexpressing reduced extracellular PGE ( 2 ) levels , suppressed the cAMP ? PKA pathway , enhanced the interaction between BRCA1 and p300 , and *inhibited* [aromatase] expression . Negative_regulation CYP19A1 TF 1744571 171907 *inhibits* [aromatase] activity of rat granulosa cells in vitro . Negative_regulation CYP19A1 TNF 10405348 629355 Inhibition of alpha *stimulated* [aromatase] activity by microtubule stabilizing agents , paclitaxel and 2-methoxyestradiol . Negative_regulation CYP19A1 TNF 16946004 1639272 activates transcription of inducible repressor form of 3',5'-cyclic adenosine 5'-monophosphate-responsive element binding modulator and *represses* P450 [aromatase] and inhibin alpha-subunit expression in rat ovarian granulosa cells by a p44/42 mitogen activated protein kinase dependent mechanism . Negative_regulation CYP19A1 TNF 16946004 1639289 Finally , the blocking of p44/42 MAPK activation prevented *inhibition* of FSH dependent increases in [P450AROM] and inhibin alpha-subunit mRNA levels , thus indicating that p44/42 MAPK mediated ICER expression may be accountable for the effects of TNFalpha on the expression of both proteins . Negative_regulation CYP19A1 TNF 19501915 2103005 also significantly *inhibited* expression of hCG , HSD3B1 and [CYP19] genes , and stimulated CYP24A1 gene expression . Negative_regulation CYP19A1 TNF 3132919 94249 ( 10 pg/ml-10 ng/ml ) *inhibited* FSH ( 250 ng/ml ) -induced [aromatase] activity in a concentration dependent manner , and 10 ng/ml of TNF completely abolished the FSH induced aromatase activity . Negative_regulation CYP19A1 TNF 7506269 237760 The mediated *inhibition* of [aromatase] activity therefore prevents the luteotrophic effects of a variety of peptides including oxytocin . Negative_regulation CYP19A1 TNF 7720683 301489 In FSH primed cells , *inhibited* [P450-AROM] activity in a dose dependent manner , an effect that was also observed in cells treated with bacterial sphingomyelinase ( SMase 0.003-0.3 U/ml ) or increasing concentrations ( 0.1-10 microM ) of N-acetylsphingosine ( C2-cer ) a membrane-permeable analogue of ceramide . Negative_regulation CYP19A1 TNF 8319591 223116 ( 20 ng/ml ) also *inhibited* Sertoli cell [aromatase] activity when stimulated with 8-bromo-cAMP ( 0.01-3 mM , 72 h ) instead of FSH , suggesting that the antigonadotropin action of the cytokine is probably exerted at a step located beyond cAMP formation . Negative_regulation CYP1A1 ARSG 10484072 643919 The CYP1A1 activity *increased* continuously up to 72 hr , where ASG showed an induction efficiency in the same range as for the positive control ( 1 microM ICZ ) after 24 hr , whereas the CYP1A1 protein level , measured by Western blot analysis , was maximally induced after 24 hr . significantly inhibited [CYP1A1] activity in whole cells at concentrations above 1 microM . Negative_regulation CYP1A1 ARSG 10484072 643923 Taken together , the results indicate that *inhibits* [CYP1A1] activity at low concentrations , but induces the same activity at higher concentrations . Negative_regulation CYP1A1 TNF 17588258 1786271 Both and LPS *repressed* the beta-naphthoflavone ( betaNF ) -mediated induction of [Cyp1a1] and Nqo1 at mRNA and activity levels . Negative_regulation CYP1A2 JAG1 23215698 2718462 In this study , we examined whether could *inhibit* the activity of [CYP1A2] in rat liver microsomes in vitro and in vivo . Negative_regulation CYP1A2 TNF 22475265 2643108 *down-regulated* the gene expression of [CYP1A2] , 2D6 and 3A4 only , whereas IL-6 down-regulated gene expression of all of the tested CYP isoforms except 2D6 . Negative_regulation CYP24A1 CALCA 7956916 277882 These data suggest that calcitonin is a potent negative regulator of I-24-OHase mRNA expression and [I-24-OHase] activity and that the release of may *block* an important pathway for the inactivation of vitamin D3 metabolites in intestine and , thereby , potentiate the toxicity of vitamin D3 during periods of its excess consumption . Negative_regulation CYP24A1 CYP27B1 15225757 1268366 Nevertheless , incubations in the presence of 8-bromo cAMP ( 1.5mM ) resulted in [CYP24] induction and *inhibition* , respectively . Negative_regulation CYP24A1 EIF2AK1 15173382 1254205 Functionally , co-expression of Sin3A enhances Alien mediated gene repression and overexpression of the alone *leads* to the inhibition of Alien mediated repression and to the induction of the endogenous [CYP24] promoter . Negative_regulation CYP24A1 IGFBP3 23770368 2815304 Moreover , real-time RT-PCR demonstrated that can *inhibit* the osteocalcin and [CYP24a1] mRNA transcription induced by 1,25- ( OH ) 2D3 in osteoblastic cells . Negative_regulation CYP24A1 IL13 23045480 2698609 We show that *enhances* the ability of 25D ( 3 ) to increase expression of hCAP18/LL-37 and [CYP24A1] . Negative_regulation CYP24A1 NR1I2 16691293 1563743 Instead , *inhibited* VDR mediated [CYP24] promoter activity , and CYP24 expression was very low in tissues containing high levels of SXR , including the small intestine . Negative_regulation CYP24A1 SNAI2 19502595 2108309 *reduces* the ligand induced VDR transcriptional activation of a consensus response element and of the [CYP24] promoter . Negative_regulation CYP24A1 YY1 11376120 818172 In summary , our results suggest that *represses* [24(OH)ase] transcription , at least in part , by sequestering activator proteins involved in VDR mediated transcription . Negative_regulation CYP26A1 RARB 16012519 1441429 DNA demethylation , histone acetylation , and exogenous overexpression of partially *restored* retinoid-responsive [CYP26A1] expression in RA-resistant MDA-MB-231 breast , but not SK-MES-1 lung , cancer cells . Negative_regulation CYP27B1 CYP24A1 15225757 1268367 Nevertheless , incubations in the presence of 8-bromo cAMP ( 1.5mM ) resulted in induction and [CYP27B1] *inhibition* , respectively . Negative_regulation CYP27B1 MAP2K6 21914460 2497156 Studies in vitro and in vivo demonstrate that activation of signaling in the kidney is *necessary* for the suppression of [CYP27B1] gene expression by FGF-23 . Negative_regulation CYP27B1 TMEM100 24247665 2876488 Klotho , a , protease and hormone mainly expressed in kidney , is *required* for the suppression of 1,25 ( OH ) 2D3 generating [25-hydroxyvitamin D3 1-alpha-hydroxylase] ( Cyp27b1 ) by FGF23 . Negative_regulation CYP27B1 TMEM156 24247665 2876506 Klotho , a , protease and hormone mainly expressed in kidney , is *required* for the suppression of 1,25 ( OH ) 2D3 generating [25-hydroxyvitamin D3 1-alpha-hydroxylase] ( Cyp27b1 ) by FGF23 . Negative_regulation CYP27B1 TMEM211 24247665 2876586 Klotho , a , protease and hormone mainly expressed in kidney , is *required* for the suppression of 1,25 ( OH ) 2D3 generating [25-hydroxyvitamin D3 1-alpha-hydroxylase] ( Cyp27b1 ) by FGF23 . Negative_regulation CYP27B1 TMEM213 24247665 2876523 Klotho , a , protease and hormone mainly expressed in kidney , is *required* for the suppression of 1,25 ( OH ) 2D3 generating [25-hydroxyvitamin D3 1-alpha-hydroxylase] ( Cyp27b1 ) by FGF23 . Negative_regulation CYP2B6 MAP2K6 17314319 1726168 On the other hand , inhibition by 1,4-diamino-2,3-dicyano-1,4-bis ( methylthio ) butadiene ( U0126 ) of an HGF downstream kinase ( MEK ) *induced* the [Cyp2b10] gene and up-regulated the CAR regulated promoter activity in the absence of TCPOBOP . Negative_regulation CYP2B6 TNF 10096772 601468 This specific down-regulation of [CYP2B1] was *mediated* exclusively by , released from the Kupffer cells . Negative_regulation CYP2C19 IL1B 10433360 633987 Western blot analysis and marker enzyme activities for individual P450 isoforms demonstrated that *suppressed* [CYP2C6] , 2C13 , 2E1 , and 3A2 , whereas CYP2A , 2B1/2 , 2C11 , and 4A1 were not influenced by the treatments . Negative_regulation CYP2C19 IL1B 11001567 580804 [Cytochrome P450-2C11 (CYP 2C11)] is down-regulated in *response* to , and this response involves the hydrolysis of sphingomyelin to ceramide as well as ceramide to sphingosine , and phosphorylation of sphingosine to sphingosine 1-phosphate . Negative_regulation CYP2C19 TNF 16415373 1520804 alpha blockade *increases* renal [Cyp2c23] expression and slows the progression of renal damage in salt-sensitive hypertension . Negative_regulation CYP2C19 TNF 16415373 1520805 These data suggest that *contributes* to downregulation of [Cyp2c23] , blood pressure regulation , and renal injury in angiotensin high-salt hypertension . Negative_regulation CYP2E1 LBP 22138659 2536253 remarkably *inhibited* [cytochrome P450 2E1] expression and restored the expression levels of antioxidant enzymes . Negative_regulation CYP3A4 FAS 14615069 1163716 The intracellular ceramide levels were significantly enhanced by the treatment with the anti-Fas antibodies and both [CYP3A4] protein and mRNA expression was *suppressed* by activation in a dose dependent manner . Negative_regulation CYP3A4 PGC 22333269 2705755 Lower expression of HNF4a and might *impair* rifampicin mediated [CYP3A4] induction under conditions where PXR is overexpressed in human fetal liver cells . Negative_regulation CYP3A4 PGC 22333269 2705757 These results suggested that lower expression of HNF4a and may *impair* RIF mediated [CYP3A4] induction under conditions of PXR overexpression in HFL cells . Negative_regulation CYP3A4 TNF 12419308 1013172 We found that bacterial sphingomyelinase ( SMase ) and , which are known to increase intracellular ceramide levels , also markedly *suppressed* the synthesis of [CYP3A4] . Negative_regulation CYP4A11 IL1B 9354589 461645 and IL-6 strongly *diminished* [CYP4A1] activity and apoprotein and mRNA levels in a dose- and time dependent manner . Negative_regulation CYP4A22 IL1B 9354589 461643 and IL-6 strongly *diminished* [CYP4A1] activity and apoprotein and mRNA levels in a dose- and time dependent manner . Negative_regulation CYP7A1 EPHB2 21097822 2377014 Furthermore , we demonstrate in vitro that suppression of [CYP7A1] by TNFa and IL-1ß is *dependent* on JNK and signaling . Negative_regulation CYP7A1 FOXO1 16885156 1613821 Insulin regulation of [cholesterol 7alpha-hydroxylase] expression in human hepatocytes : *roles* of and sterol regulatory element binding protein 1c . Negative_regulation CYP7A1 FOXO1 19463968 2128299 This study investigated the *roles* of in the regulation of [cholesterol 7alpha-hydroxylase] ( CYP7A1 ) gene expression in primary human hepatocytes . Negative_regulation CYP7A1 FOXO1 19463968 2128302 Adenovirus mediated expression of a phosphorylation defective and constitutively active form of ( FoxO1-ADA ) *inhibited* [CYP7A1] mRNA expression and bile acid synthesis , while siRNA knockdown of FoxO1 resulted in a approximately 6-fold induction of CYP7A1 mRNA in human hepatocytes . Negative_regulation CYP7A1 FOXO1 19463968 2128304 Insulin caused rapid exclusion of FoxO1 from the nucleus and resulted in the induction of [CYP7A1] mRNA expression , which was *blocked* by . Negative_regulation CYP7A1 FOXO1 19463968 2128308 Impaired regulation of may *cause* down-regulation of [CYP7A1] gene expression and contribute to dyslipidemia in insulin resistance . Negative_regulation CYP7A1 FOXO1 21817852 2495535 However , ectopic expression of increased the rat CYP7A1- , but mildly *reduced* human [CYP7A1-promoter] activities in a dose dependent manner . Negative_regulation CYP7A1 IL1B 15550563 1380573 Real-time PCR assays revealed that both chenodeoxycholic acid (CDCA) and markedly *reduced* CYP8B1 , cholesterol 7alpha-hydroxylase [CYP7A1] and hepatic nuclear factor 4alpha ( HNF4alpha ) mRNA expression levels in human primary hepatocytes . Negative_regulation CYP7A1 IL1B 16729332 1565778 and CDCA *reduced* [CYP7A1] but induced c-Jun messenger RNA expression in human primary hepatocytes . Negative_regulation CYP7A1 IL1B 16729332 1565786 *inhibited* human [CYP7A1] reporter activity via the HNF4 alpha binding site . Negative_regulation CYP7A1 TNF 16049268 1447766 Herein , to clarify the *role* of in LN-induced downregulation of [cholesterol 7alpha-hydroxylase] , effects of LN on gene expression of hepatic cholesterol 7alpha-hydroxylase ( Cyp7a1 ) in TNF-alpha-knockout ( KO ) and TNF-alpha-wild-type ( WT ) mice were comparatively examined . Negative_regulation CYP7A1 TNF 18511845 1945192 Furthermore , and cJun *attenuated* TGFbeta1 stimulation of rat [Cyp7a1] . Negative_regulation CYP8B1 IL1B 15550563 1380575 *inhibited* human [CYP8B1] reporter activity only in liver cells , and a c-Jun NH ( 2 ) -terminal kinase ( JNK ) -specific inhibitor blocked IL-1beta inhibition . Negative_regulation CYP8B1 IL1B 15550563 1380576 Activated JNK1 or c-Jun inhibited , whereas their dominant negative forms blocked , *inhibition* of [CYP8B1] transcription . Negative_regulation CYP8B1 IL1B 15550563 1380582 These results suggest that *inhibits* [CYP8B1] gene transcription via a mitogen activated protein kinase/JNK pathway that inhibits HNF4alpha gene expression and its DNA binding ability . Negative_regulation CYR61 ID1 18764931 1969031 Furthermore , using TaqMan Low-density Arrays we identified key pro-angiogenic genes induced by CRP among them were vascular endothelial cell growth factor receptor-2 ( VEGFR2/KDR ) , platelet derived growth factor ( PDGF-BB ) , notch family transcription factors ( Notch1 and Notch3 ) , cysteine-rich angiogenic inducer 61 ( [CYR61/CCN1] ) and *inhibitor* of DNA binding/differentiation-1 ( ) . Negative_regulation CYSLTR1 ALOX5 10765473 580078 Two strategies for modulating the actions of the leukotrienes are currently undergoing clinical evaluation : [cysteinyl leukotriene receptor] antagonism and <5-lipoxygenase (5-LO)> *inhibition* . Negative_regulation CYSLTR1 EPHB2 19561298 2110642 The membrane expression of the [CysLT(1)R] analyzed by FACS with anti-Myc Ab was not reduced by the cotransfection , yet both LTD ( 4 ) -elicited phosphorylation and the specific binding of [ ( 3 ) H ] LTD ( 4 ) to microsomal membranes were fully *inhibited* . Negative_regulation CYSLTR2 ALOX5 10765473 580079 Two strategies for modulating the actions of the leukotrienes are currently undergoing clinical evaluation : [cysteinyl leukotriene receptor] antagonism and <5-lipoxygenase (5-LO)> *inhibition* . Negative_regulation CYSLTR2 IL1B 12816881 1120776 Lipopolysaccharide , tumor necrosis factor-alpha , or *caused* a rapid ( within 30 minutes ) and partially reversible suppression of [CysLT2R] mRNA levels . Negative_regulation CYSLTR2 TNF 12816881 1120775 Lipopolysaccharide , , or interleukin-1beta *caused* a rapid ( within 30 minutes ) and partially reversible suppression of [CysLT2R] mRNA levels . Negative_regulation CYSLTR2 TNF 19042113 1998805 Interestingly , also *reduced* [CysLT2R] expression in cancer cells . Negative_regulation CYTL1 TNF 7628389 316409 *inhibition* of 17 [alpha-hydroxylase/C17-20] lyase gene ( Cyp17 ) expression . Negative_regulation DAPK1 MYLIP 22593189 2625182 *mediated* downregulation of [DAPK] and KLF4 also enabled the colonization of CRC cells at a metastatic site . Negative_regulation DAPK1 MYLIP 22593189 2625186 Our findings therefore indicate that *mediated* repression of [DAPK] and KLF4 promotes metastasis in CRC , and this regulatory circuit may contribute in part to hypoxia stimulated tumor metastasis . Negative_regulation DAPK1 TIMP3 12660028 1074106 We have determined the promoter CpG island methylation status of O(6)-methylguanine-DNA methyltransferase ( MGMT ) , glutathione-S-transferase P1 (GSTP1) , [death associated protein kinase (DAPK)] , p14 ( ARF ) , thrombospondin-1 (THBS1) , tissue *inhibitor* of metalloproteinase-3 gene ( ) , p73 , p16(INK4A) , RB1 , and TP53 genes in three primary central nervous system lymphomas ( PCNSL ) . Negative_regulation DAPK1 TNF 17056602 1654571 In this study , we confirmed the existence of the alternatively spliced human DAPK-beta , and we examined the levels of DAPK autophosphorylation and [DAPK] catalytic activity in *response* to or ceramide . Negative_regulation DAPK1 TP53 22170404 2563270 It stimulated the phosphorylation of adenosine monophosphate activated protein kinase ( AMPK ) and , but *inhibited* the phosphorylation of [death associated protein kinase (DAPK)] . Negative_regulation DAPK2 TNF 17056602 1654572 In this study , we confirmed the existence of the alternatively spliced human DAPK-beta , and we examined the levels of DAPK autophosphorylation and [DAPK] catalytic activity in *response* to or ceramide . Negative_regulation DAPK3 TNF 17056602 1654573 In this study , we confirmed the existence of the alternatively spliced human DAPK-beta , and we examined the levels of DAPK autophosphorylation and [DAPK] catalytic activity in *response* to or ceramide . Negative_regulation DBH EPHB2 12609984 1079775 They further suggest that activity *inhibits* basal [DBH] gene expression . Negative_regulation DBH MAP2K6 12842874 1141093 Pharmacogenomic studies with microarrays showed that protein kinase A , , and casein kinase II inhibitors *blocked* induction of [DBH] and a large subset of ethanol-responsive genes . Negative_regulation DCC UNC5B 21820492 2485197 Quantitative reverse transcription polymerase chain reaction ( qPCR ) and Western blot analysis revealed that treadmill exercise *enhanced* netrin-1 and [DCC] expression , while it suppressed expression in rat peri-ischemic brain area , especially at day 14 and 28 after MCAO ( n = 4 , P < 0.05 or P < 0.01 ) . Negative_regulation DCN TNF 9485085 488224 In contrast , *resulted* in a marked increase in [decorin] mRNA levels ( +260 % ) that was not the result of transcriptional regulation . Negative_regulation DCP2 TNF 2226778 144483 Stability studies of IL-6 transcripts in fibroblasts showed that *delayed* IL-6 [mRNA decay] but not LT . Negative_regulation DCPS SMN2 23727836 2843805 Quinazolines increase promoter activity and *inhibit* the ribonucleic acid scavenger enzyme [DcpS] . Negative_regulation DCT MAP2K6 11310793 804825 Studies using inhibitors for protein kinases involved in cell signaling pathways suggested that stress activated kinase p38 and mitogen activated protein kinase kinase are *involved* in TPA independent regulation of [TYRP2] expression in melanocytes . Negative_regulation DDB1 EPHB2 18332868 1925102 Consistently , VprBP depletion abolished the in vivo interaction of Merlin and [Roc1-Cullin4A-DDB1] , which resulted in Merlin stabilization and *inhibited* and Rac activation . Negative_regulation DDIT3 TLR7 22231169 2544696 Each of these processes is required for *mediated* [CHOP] suppression in ER-stressed cells in vitro and in vivo . Negative_regulation DDT TNF 18755234 1975295 However , in presence lipopolysaccharide , [DDT] *induced* significant ( p < 0.05 ) suppression of and NO generation , suggestive of impairment of macrophage microbiocidal effects . Negative_regulation DEFA1B TNF 20525314 2295374 also *inhibited* [HNP1-3] levels from OA but not from RA cells . Negative_regulation DEFB4B SPHK1 20634980 2292175 Overexpression of with concomitant inhibition of GSK-3beta *enhanced* the induction of [beta-defensin-2] in oral keratinocytes . Negative_regulation DEFB4B TNF 21367976 2431742 IFN-? , IL-17 , IL-22 , , IL-1ß , and IL-6 enhanced , and IL-10 , IL-4 , and IL-13 *suppressed* [hBD-2] secretion from keratinocytes . Negative_regulation DEK TNF 16829531 1606410 [DEK] expression blocked p65 mediated activation of an NF-kappaB dependent reporter gene and also *inhibited* induced activation of the reporter gene . Negative_regulation DEPTOR EPHB2 24458360 2933088 In cultured myotubes , inhibition of , but not Jun NH2-terminal kinase and I?B kinase , *blocked* the downregulation of Baf60c and [Deptor] by the proinflammatory cytokine tumor necrosis factor-a . Negative_regulation DES CAPN8 17513494 1783995 We next determined that ventricular myocytes that underwent Ca ( 2+ ) overload also demonstrated a *dependent* disruption of [desmin] that could be reduced by H ( 2 ) O ( 2 ) /p38 MAPK activation . Negative_regulation DES RARB 12223147 987671 Transfection of RAR-beta gene and treatment with ligand ATRA could increase the expression of protein for at least 144h and *inhibit* the proliferation and the expression of alpha-SMA and [desmin] in PDGF activated HSC . Negative_regulation DEXI EPHB2 24846141 2945313 Phosphorylation of by this compound increased protein synthesis by activating MTOR and *prevented* [dexamethasone induced protein] degradation by blocking FoxO3a activity , but it did not alter Akt phosphorylation . Negative_regulation DIABLO MAP2K6 17877640 1796709 In another clone ( PC70 ) , ICP10PK inhibited apoptosis through *dependent* up-regulation of the anti-apoptotic protein XIAP ( that inhibits the activity of processed caspase-3 ) and down-regulation of the apoptogenic protein [Smac/DIABLO] . Negative_regulation DIABLO TNFSF10 11948412 930155 In contrast , in SKW lymphoblastoid cells , induced activation of caspase-8 directly translated into full activation of caspases , cleavage of XIAP , DFF45 or PARP and apoptosis independent of Bcl-2 overexpression , although Bcl-2 similarly *inhibited* loss of mitochondrial membrane potential and the release of cytochrome c , AIF and [Smac] from mitochondria in all cell types . Negative_regulation DIABLO TNFSF10 15475369 1319204 Instead , in the presence of DcR3 , engagement *resulted* in an increased activation of caspase-8 , an elevated cleavage of Bid , and enhanced release of [Smac] and cytochrome c from mitochondria to cytosol compared with TRAIL alone . Negative_regulation DIANPH CTGF 15012739 1183021 The present study was designed to elucidate the *role* of in [diabetic nephropathy (DN)] , immunoglobulin A nephropathy (IgA-N) , membranous nephropathy ( MN ) , and minimal change nephrotic syndrome ( MCNS ) . Negative_regulation DIANPH CTGF 16380465 1553972 Temporal expression profile and distribution pattern indicate a *role* of ( CTGF/CCN-2 ) in [diabetic nephropathy] in mice . Negative_regulation DIANPH CTGF 18235518 1864364 Unraveling the *role* of in [diabetic nephropathy] . Negative_regulation DIANPH SPON2 22235198 2519496 *Role* of in [diabetic nephropathy] . Negative_regulation DIANPH TNF 17113815 1651165 The *role* of in [diabetic nephropathy] : pathogenic and therapeutic implications . Negative_regulation DIANPH TNFSF10 21251686 2452988 To investigate the *role* of in [diabetic nephropathy] , we measured the serum concentrations of OPG and TRAIL in type 2 diabetes mellitus patients with different stages of nephropathy by enzyme linked immunosorbent assay . Negative_regulation DIO1 IL1B 11916626 925476 IL-6 at 500 pg/ml and TNF-alpha at 25 ng/ml had no significant effect , whereas 100 ng/ml IFN-gamma or 10 ng/ml *reduced* [5'DI] enzyme activity to 77.9 and 59.5 % of control values . Negative_regulation DIO1 IL1B 11916626 925478 IFN-gamma did not alter , IL-6 and TNF-alpha moderately decreased ( in the case of IL-6 only in the CAT system ) , and ( 0.01-10 ng/ml ) dose-dependently *inhibited* [5'DI] promoter activity to a minimum of 38.1 % . Negative_regulation DIO1 IL1B 11916626 925479 *inhibited* both [5'DI] enzyme and promoter activity and , thus , may exert its effect on thyroid hormone metabolism at least partially through direct inhibition of hepatic 5'DI gene transcription . Negative_regulation DIO1 TNF 7867596 296471 In TSH deprived FRTL-5 cells , and IFN-gamma *resulted* in a small but dose dependent decrease in [5'D-I] activity . Negative_regulation DIO1 TNF 7867596 296475 or IFN-gamma *blocked* the TSH- or cAMP induced rise in [5'D-I] activity . Negative_regulation DIO1 TNF 8180680 256326 This TSH induced increase in [5'D-I] was *attenuated* by in a dose dependent manner ( p < 0.001 ) . Negative_regulation DIO1 TNF 8180680 256327 Enzyme kinetic analysis demonstrated that thyrotropin increased 5'D-I by increasing Vmax ( p < 0.01 ) without significantly affecting Km. Likewise , TNF-alpha decreased the thyrotropin induced 5'D-I by decreasing Vmax ( p < 0.05 ) but not Km. The effect of TNF-alpha on thyrotropin induced 5'D-I in FRTL-5 cells is probably mediated through post-thyrotropin induced generation of cyclic adenosine monophosphate ( cAMP ) because *inhibited* both dibutyryl cAMP ( p < 0.001 ) and forskolin ( p < 0.001 ) -induced increases in [5'D-I] without affecting cAMP generation stimulated by thyrotropin . Negative_regulation DIO1 TNF 8180680 256331 In conclusion , we have demonstrated that *inhibits* thyrotropin induced [5'D-I] activity in FRTL-5 cells by pathways distal to the generation of cAMP and that TNF-alpha may play a role in the modulation of the production of triiodothyronine by the thyroid gland . Negative_regulation DIRAS3 CCND1 22528939 2681373 [ARHI] expression *inhibited* expression in SK-BR-3 cells and JIMT-1 cells , while it promoted p27 ( Kip1 ) and calpain1 expression in these cells . Negative_regulation DISC1 TNF 23423194 2755351 Our findings suggest that the cytoprotective effects of HO-1 are *mediated* by suppression of mediated apoptotic signaling , specifically by modulating apoptotic [DISC] formation and mitochondrial TNFR1 translocation during hepatic I/R . Negative_regulation DISC1 TNFSF10 20484047 2283422 However , in cells susceptible to TRAIL treatment , *induces* a reduction in MADD phosphorylation levels resulting in MADD dissociation from , and Fas associated death domain association with DR4 , which allows [death inducing signaling complex (DISC)] formation leading to apoptosis . Negative_regulation DISC2 TNF 23423194 2755353 Our findings suggest that the cytoprotective effects of HO-1 are *mediated* by suppression of mediated apoptotic signaling , specifically by modulating apoptotic [DISC] formation and mitochondrial TNFR1 translocation during hepatic I/R . Negative_regulation DISC2 TNFSF10 20484047 2283423 However , in cells susceptible to TRAIL treatment , *induces* a reduction in MADD phosphorylation levels resulting in MADD dissociation from , and Fas associated death domain association with DR4 , which allows [death inducing signaling complex (DISC)] formation leading to apoptosis . Negative_regulation DKC1 EPHB2 12223143 987664 HRT , VCR , and Vp16 could inhibit cell proliferation ( 0.28 % 0.08 % , 0.25 % 0.16 % , 0.24 % 0.11 % ) , induce apoptosis ( 21.12 % , 28.83 % , 12.30 % ) , *inhibit* [telomerase] activity , and down-regulate the protein expression of phosphorylated . Negative_regulation DKC1 EPHB2 12674761 1030440 The results showed that HRT , VCR and Vp16 could inhibit cell proliferation , induce apoptosis , *inhibit* [telomerase] activity and down-regulate the protein expression of phosphorylated . Negative_regulation DKC1 TNFSF10 23358473 2758703 In recent years , studies have shown that therapeutic agents such as metformin , salinomycin , DECA-14 , rapamycin , oncostatin M (OSM) , some natural compounds , oncolytic viruses , microRNAs , cell signaling pathway inhibitors , TNF related apoptosis inducing ligand ( ) , interferon ( IFN ) , [telomerase] *inhibitors* , all-trans retinoic acid ( ATRA ) and monoclonal antibodies can suppress the self-renewal of CSCs in vitro and in vivo . Negative_regulation DKC1 ZFP57 20145034 2214656 The *repression* of [telomerase] expression by artificial targeting the promoter region of the hTERT presents a new promising strategy for inhibiting the growth of human cancer cells . Negative_regulation DKK1 TNF 25228904 2958349 [DKK-1] mRNA expression was *inhibited* by and IL-17A either alone or combined . Negative_regulation DLD COL17A1 12786825 1096730 This reflects the pivotal *role* of in [LAD] . Negative_regulation DLD ITGB2 11249768 764208 [LAD] *results* from heterogeneous molecular defects in the leukocyte integrin , which prevent CD11/CD18 heterodimer formation and surface expression . Negative_regulation DLL3 EPHB2 23533157 2804069 Mechanistically , dependent induction of miR-18a* directly *represses* expression of [DLL3] , an autocrine inhibitor of NOTCH , thus enhancing the level of activated NOTCH-1 . Negative_regulation DMD TNF 20373002 2282040 Pretreatment of these cells with MG132 , an inhibitor of nuclear factor kappa B (NF-kappaB) pathway , abolished *induced* reduction in mRNA levels of [dystrophin] and titin . Negative_regulation DMKN EPHB2 22735594 2634311 Inhibition of signaling by its specific inhibitor also *increased* [dermokine] expression level . Negative_regulation DNM1 CAPN8 16002400 1452845 In addition , our results provided evidence that the Abeta induced decrease in dynamin 1 was likely the result of a *mediated* cleavage of dynamin 1 protein and possibly the down-regulation of [dynamin 1] gene expression . Negative_regulation DNMT1 PLAT 24117907 2902790 Ethanol also increased protein expression and release , and *inhibited* [DNMT] activity with a corresponding decrease in DNA methylation levels of the tPA promoter . Negative_regulation DPP4 GLP1R 18801896 2012285 Here we investigated whether acute activation ( exendin-4 ) or [DPP-4] *inhibition* ( des-F-sitagliptin ) modulates insulin action in mice using a hyperinsulinemic euglycemic clamp . Negative_regulation DPP4 GLP1R 19925389 2167108 This is also further complicated by the availability of new incretin based therapies , the [dipeptidylpeptidase-4 (DPP-IV)] *inhibitors* and glucagon-like-1 receptor ( ) analogues . Negative_regulation DPP4 GLP1R 22323472 2580561 Both activation and [DPP-4] *inhibition* exert multiple cardioprotective actions in preclinical models of cardiovascular dysfunction , and short-term studies in human subjects appear to demonstrate modest yet beneficial actions on cardiac function in subjects with ischemic heart disease . Negative_regulation DPP4 GLP1R 24375052 2906659 The incretin based agents -- agonists of glucagon-like peptide 1 receptor ( ) and *inhibitors* of [dipeptidyl peptidase 4 (DPP-4)] , an enzyme that degrades glucagon-like peptide 1 -- are novel blood-glucose lowering drugs used in the treatment of type 2 diabetes mellitus ( T2DM ) . Negative_regulation DPP4 GLP1R 24855202 2940683 Activation of signaling or *inhibition* of [DPP-4] activity produces a broad range of overlapping and unique cardiovascular actions . Negative_regulation DRD1 ZIC2 10984499 752156 and Sp3 *repress* Sp1 induced activation of the human [D1A dopamine receptor] gene . Negative_regulation DRG1 TNF 11849773 912919 To further understand the *role* of in [DRG] , we injected rat L5 DRG with biotinylated TNF alpha , neurobiotin , or vehicle , and detected translocation of the biotin tag by avidin-biotin histochemistry . Negative_regulation DRG2 TNF 11849773 912920 To further understand the *role* of in [DRG] , we injected rat L5 DRG with biotinylated TNF alpha , neurobiotin , or vehicle , and detected translocation of the biotin tag by avidin-biotin histochemistry . Negative_regulation DTNA SYNC 12467731 1032212 We speculate that the loss of [alpha-dystrobrevin] from the membrane , and subsequent loss of nNOS , is *due* to the interaction . Negative_regulation DUSP1 EPHB2 24253595 2910451 We examined the *role* of in the regulation of [MKP1] and JNK , and p38 activities and apoptosis . Negative_regulation DUSP1 EPHB2 9774360 539706 In addition , PD 098059 , an antagonist of MEK ( MAP kinase/ERK kinase ) , the upstream kinase of ERK , significantly reduced the PDGF induced activation of and potently *inhibited* the expression of [MKP-1] after stimulation with PDGF , thereby demonstrating the induction of MKP-1 in response to activation of the ERK signaling cascade . Negative_regulation DUSP1 MAP2K6 11435498 832581 Killing of both C. albicans and S. cerevisiae could be reduced using PD98059 , which mimics [MKP-1] and *inhibits* phosphorylation , suggesting that specific MKP-1 activation by C. albicans could contribute to its ability to escape the yeast lytic potential of macrophages . Negative_regulation DUSP1 MAP2K6 24253595 2910457 We examined the *role* of in the regulation of [MKP1] and JNK , and p38 activities and apoptosis . Negative_regulation DUSP1 PDE4B 22610099 2619886 *inhibits* [MKP-1] expression in a cAMP-PKA dependent manner . Negative_regulation DUSP1 TNF 23812841 2838828 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP10 TNF 23812841 2838829 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP11 TNF 23812841 2838830 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP12 TNF 23812841 2838831 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP13 TNF 23812841 2838823 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP14 TNF 23812841 2838819 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP15 TNF 23812841 2838818 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP16 TNF 22182512 2543298 induced phosphor-JNK levels *increased* after 5min , peaked at 10 min , and decreased after 30 min. Interestingly , [MKP-7] protein levels increased after 30 min , when phosphor-JNK induction by TNF-a was decreased . Negative_regulation DUSP16 TNF 23812841 2838820 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP18 TNF 23812841 2838821 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP19 TNF 23812841 2838822 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP2 TNF 23812841 2838832 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP21 TNF 23812841 2838824 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP22 TNF 23812841 2838817 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP23 TNF 23812841 2838825 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP26 TNF 23812841 2838827 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP27 TNF 23812841 2838826 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP28 TNF 23812841 2838840 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP3 TNF 23812841 2838833 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP4 TNF 23812841 2838816 *mediated* suppression of [dual-specificity phosphatase 4] : crosstalk between NF?B and MAPK regulates endothelial cell survival . Negative_regulation DUSP4 TNF 23812841 2838834 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP4 TNF 23812841 2838841 Pharmacological inhibition of NF?B activation or a dominant negative construct of the inhibitor of ?B significantly lessened TNF-a mediated suppression of DUSP4 expression by 70-84 % and attenuated ERK activation , implicating NF?B dependent pathways in the *mediated* suppression of [DUSP4] that contributes to ERK1/2 signaling . Negative_regulation DUSP5 TNF 23812841 2838835 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP6 TNF 23812841 2838836 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP7 TNF 23812841 2838837 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP8 TNF 23812841 2838838 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DUSP9 TNF 23812841 2838839 *caused* a significant suppression of a [dual specificity phosphatase] , DUSP4 , that regulates ERK1/2 activation . Negative_regulation DVL1 TNF 20628365 2321891 [Dvl] expression *inhibits* p65 mediated or stimulated activation of the NF-?B dependent reporter . Negative_regulation DVL2 TNF 20628365 2321893 [Dvl] expression *inhibits* p65 mediated or stimulated activation of the NF-?B dependent reporter . Negative_regulation DVL3 TNF 20628365 2321895 [Dvl] expression *inhibits* p65 mediated or stimulated activation of the NF-?B dependent reporter . Negative_regulation DYRK1B CCND1 22711815 2621366 Cirp did not affect binding of [Dyrk1b] to cyclin D1 but *inhibited* phosphorylation of by Dyrk1b , resulting in cyclin D1 stabilization . Negative_regulation DYSF TNF 18276788 1872078 siRNA mediated inhibition of [dysferlin] expression in the J774 macrophage cell line resulted in significantly enhanced phagocytosis , both at baseline and in *response* to . Negative_regulation E2F1 CCND1 11739785 886750 Inhibition of expression with antisense oligonucleotides *causes* a delay in progression of chondrocytes through the G1 phase of the cell cycle , reduced [E2F] activity , and decreased proliferation . Negative_regulation E2F1 CCND1 16479154 1534710 In pRb-null U266 cells , enforced overexpression of diminished CDK inhibitor mediated dephosphorylation of the pocket proteins p130 and p107 , reduced binding of E2F1 and E2F4 to p130 and p107 , and *attenuated* inhibition of [E2F] activity . Negative_regulation E2F1 CCND1 7970707 280120 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Negative_regulation E2F1 IFI27 10417394 631601 [E2F-1] overexpression in cardiomyocytes *induces* downregulation of p21CIP1 and and release of active cyclin dependent kinases in the presence of insulin-like growth factor I . Negative_regulation E2F1 STK39 12657366 1073233 NF-kappaB , the c-jun N-terminal kinase-c-Jun pathway , p53 , [E2F1] , and other transcription factors are probably all involved in regulating the expression of BH3-only proteins after brain ischaemia , and mitochondrial translocation of Bad from sequestering cytosolic proteins is *promoted* by inactivation of the , Akt . Negative_regulation E2F2 CCND1 11739785 886751 Inhibition of expression with antisense oligonucleotides *causes* a delay in progression of chondrocytes through the G1 phase of the cell cycle , reduced [E2F] activity , and decreased proliferation . Negative_regulation E2F2 CCND1 16479154 1534711 In pRb-null U266 cells , enforced overexpression of diminished CDK inhibitor mediated dephosphorylation of the pocket proteins p130 and p107 , reduced binding of E2F1 and E2F4 to p130 and p107 , and *attenuated* inhibition of [E2F] activity . Negative_regulation E2F2 CCND1 7970707 280121 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Negative_regulation E2F3 CCND1 11739785 886752 Inhibition of expression with antisense oligonucleotides *causes* a delay in progression of chondrocytes through the G1 phase of the cell cycle , reduced [E2F] activity , and decreased proliferation . Negative_regulation E2F3 CCND1 16479154 1534712 In pRb-null U266 cells , enforced overexpression of diminished CDK inhibitor mediated dephosphorylation of the pocket proteins p130 and p107 , reduced binding of E2F1 and E2F4 to p130 and p107 , and *attenuated* inhibition of [E2F] activity . Negative_regulation E2F3 CCND1 7970707 280122 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Negative_regulation E2F4 CCND1 11739785 886753 Inhibition of expression with antisense oligonucleotides *causes* a delay in progression of chondrocytes through the G1 phase of the cell cycle , reduced [E2F] activity , and decreased proliferation . Negative_regulation E2F4 CCND1 16479154 1534713 In pRb-null U266 cells , enforced overexpression of diminished CDK inhibitor mediated dephosphorylation of the pocket proteins p130 and p107 , reduced binding of E2F1 and E2F4 to p130 and p107 , and *attenuated* inhibition of [E2F] activity . Negative_regulation E2F4 CCND1 7970707 280123 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Negative_regulation E2F5 CCND1 11739785 886754 Inhibition of expression with antisense oligonucleotides *causes* a delay in progression of chondrocytes through the G1 phase of the cell cycle , reduced [E2F] activity , and decreased proliferation . Negative_regulation E2F5 CCND1 16479154 1534714 In pRb-null U266 cells , enforced overexpression of diminished CDK inhibitor mediated dephosphorylation of the pocket proteins p130 and p107 , reduced binding of E2F1 and E2F4 to p130 and p107 , and *attenuated* inhibition of [E2F] activity . Negative_regulation E2F5 CCND1 7970707 280124 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Negative_regulation E2F6 CCND1 11739785 886755 Inhibition of expression with antisense oligonucleotides *causes* a delay in progression of chondrocytes through the G1 phase of the cell cycle , reduced [E2F] activity , and decreased proliferation . Negative_regulation E2F6 CCND1 16479154 1534715 In pRb-null U266 cells , enforced overexpression of diminished CDK inhibitor mediated dephosphorylation of the pocket proteins p130 and p107 , reduced binding of E2F1 and E2F4 to p130 and p107 , and *attenuated* inhibition of [E2F] activity . Negative_regulation E2F6 CCND1 7970707 280125 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Negative_regulation E2F7 CCND1 11739785 886748 Inhibition of expression with antisense oligonucleotides *causes* a delay in progression of chondrocytes through the G1 phase of the cell cycle , reduced [E2F] activity , and decreased proliferation . Negative_regulation E2F7 CCND1 16479154 1534708 In pRb-null U266 cells , enforced overexpression of diminished CDK inhibitor mediated dephosphorylation of the pocket proteins p130 and p107 , reduced binding of E2F1 and E2F4 to p130 and p107 , and *attenuated* inhibition of [E2F] activity . Negative_regulation E2F7 CCND1 7970707 280118 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Negative_regulation E2F8 CCND1 11739785 886749 Inhibition of expression with antisense oligonucleotides *causes* a delay in progression of chondrocytes through the G1 phase of the cell cycle , reduced [E2F] activity , and decreased proliferation . Negative_regulation E2F8 CCND1 16479154 1534709 In pRb-null U266 cells , enforced overexpression of diminished CDK inhibitor mediated dephosphorylation of the pocket proteins p130 and p107 , reduced binding of E2F1 and E2F4 to p130 and p107 , and *attenuated* inhibition of [E2F] activity . Negative_regulation E2F8 CCND1 7970707 280119 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Negative_regulation EBP TNF 16754199 1571443 In addition , *down-regulated* insulin induced [CCAAT/enhancer binding protein (C/EBP)-alpha] gene expression and DNA binding activity , but fumonisin B precludes these effects . Negative_regulation ECE1 TNF 11775854 581310 induced ET-1 release and [ECE] mRNA expression from human ASMC are *inhibited* by antisense oligonucleotide of ECE . Negative_regulation ECE1 TNF 9032126 414764 *resulted* in a significant increase in [ECE-1] mRNA expression . Negative_regulation ECM1 CTGF 15579446 1344857 To determine the critical *role* of in AGE induced [ECM] accumulation leading to diabetic nephropathy , rats were given AGEs by intravenous injection for 6 weeks . Negative_regulation ECM1 CTGF 17393107 1716259 In order to investigate the effects of connective tissue growth factor (CTGF) antisense oligodeoxynucleotide ( ODN ) on plasminogen activator inhibitor-1 ( PAI-1 ) expression in renal tubular cells induced by transforming growth factor beta1 ( TGF-beta1 ) and to explore the *role* of in the degradation of renal [extracellular matrix (ECM)] , a human proximal tubular epithelial cell line ( HKC ) was cultured in vitro . Negative_regulation ECM1 MMP28 14609564 1162401 Inhibition of activity through elevated levels of TGF-beta2 might *contribute* to the increase in [ECM] in the trabecular meshwork of glaucomatous eyes . Negative_regulation ECM1 MMP28 16565411 1538977 Accordingly , loss of RPE activity most likely *leads* to excessive accumulation of collagen and other [ECM] , a potential mechanism for formation of deposits . Negative_regulation ECM1 MMP7 14609564 1162416 Inhibition of activity through elevated levels of TGF-beta2 might *contribute* to the increase in [ECM] in the trabecular meshwork of glaucomatous eyes . Negative_regulation ECM1 MMP7 16565411 1538992 Accordingly , loss of RPE activity most likely *leads* to excessive accumulation of collagen and other [ECM] , a potential mechanism for formation of deposits . Negative_regulation ECM1 PLAT 16038272 1437337 To study the *role* of plasminogen activator inhibitor-1 ( PAI-1 ) and in the accumulation of [extracellular matrix (ECM)] in the kidney of KKAy mice with type 2 diabetes . Negative_regulation ECM1 PLAU 19181000 2007117 Herein we have focused on the *role* of ( uPA ) and transforming growth factor beta 1 ( TGF/1 ) in [ECM] degradation and reconstitution in muscles . Negative_regulation ECM1 PLAU 7540230 307178 [ECM] degradation was *reduced* by a monoclonal antibody ( MAb ) against human tPA ( -54 +/- 8.6 % ) or human ( -39 +/- 5.2 % ) compared to cells treated with identical amounts of non-specific monoclonal IgG ( P < 0.01 ) . ( Negative_regulation ECM1 TGM2 16936095 1608916 In the present study , the *role* of in the accumulation of [extracellular matrix (ECM)] proteins in these scars was investigated . Negative_regulation ECM1 TNF 10629048 659290 The proinflammatory cytokine *inhibits* [ECM] accumulation by stimulating the expression of matrix proteolytic enzymes and by downregulating the deposition of structural macromolecules such as type I collagen . Negative_regulation ECM1 TNF 7797231 313843 Thus , IL-1 + enhanced neutrophil and EC degradation of the ECM but *inhibited* lymphocyte [ECM] degradation . Negative_regulation ECM2 CTGF 15579446 1344858 To determine the critical *role* of in AGE induced [ECM] accumulation leading to diabetic nephropathy , rats were given AGEs by intravenous injection for 6 weeks . Negative_regulation ECM2 CTGF 17393107 1716260 In order to investigate the effects of connective tissue growth factor (CTGF) antisense oligodeoxynucleotide ( ODN ) on plasminogen activator inhibitor-1 ( PAI-1 ) expression in renal tubular cells induced by transforming growth factor beta1 ( TGF-beta1 ) and to explore the *role* of in the degradation of renal [extracellular matrix (ECM)] , a human proximal tubular epithelial cell line ( HKC ) was cultured in vitro . Negative_regulation ECM2 MMP28 14609564 1162423 Inhibition of activity through elevated levels of TGF-beta2 might *contribute* to the increase in [ECM] in the trabecular meshwork of glaucomatous eyes . Negative_regulation ECM2 MMP28 16565411 1539000 Accordingly , loss of RPE activity most likely *leads* to excessive accumulation of collagen and other [ECM] , a potential mechanism for formation of deposits . Negative_regulation ECM2 MMP7 14609564 1162438 Inhibition of activity through elevated levels of TGF-beta2 might *contribute* to the increase in [ECM] in the trabecular meshwork of glaucomatous eyes . Negative_regulation ECM2 MMP7 16565411 1539015 Accordingly , loss of RPE activity most likely *leads* to excessive accumulation of collagen and other [ECM] , a potential mechanism for formation of deposits . Negative_regulation ECM2 PLAT 16038272 1437339 To study the *role* of plasminogen activator inhibitor-1 ( PAI-1 ) and in the accumulation of [extracellular matrix (ECM)] in the kidney of KKAy mice with type 2 diabetes . Negative_regulation ECM2 PLAU 19181000 2007119 Herein we have focused on the *role* of ( uPA ) and transforming growth factor beta 1 ( TGF/1 ) in [ECM] degradation and reconstitution in muscles . Negative_regulation ECM2 PLAU 7540230 307179 [ECM] degradation was *reduced* by a monoclonal antibody ( MAb ) against human tPA ( -54 +/- 8.6 % ) or human ( -39 +/- 5.2 % ) compared to cells treated with identical amounts of non-specific monoclonal IgG ( P < 0.01 ) . ( Negative_regulation ECM2 TGM2 16936095 1608917 In the present study , the *role* of in the accumulation of [extracellular matrix (ECM)] proteins in these scars was investigated . Negative_regulation ECM2 TNF 10629048 659291 The proinflammatory cytokine *inhibits* [ECM] accumulation by stimulating the expression of matrix proteolytic enzymes and by downregulating the deposition of structural macromolecules such as type I collagen . Negative_regulation ECM2 TNF 7797231 313845 Thus , IL-1 + enhanced neutrophil and EC degradation of the ECM but *inhibited* lymphocyte [ECM] degradation . Negative_regulation EDC3 AGR2 16389457 1512750 When added to cultures of transformed cells , [EDC] *induced* blockade followed by cell death . Negative_regulation EDC4 AGR2 16389457 1512749 When added to cultures of transformed cells , [EDC] *induced* blockade followed by cell death . Negative_regulation EDN1 ANGPT1 16741035 1566599 [ET-1] release from cultured endothelial cells was dose-dependently *reduced* by , which also prevented induction of ET-1 release by TNF-alpha ( P < 0.05 ) . Negative_regulation EDN1 ANGPT1 16741035 1566601 gene transfer *attenuated* the LPS induced increases in ppET-1 RNA and lavage [ET-1] protein by 34 % and 33 % , respectively ( P < 0.05 ) . Negative_regulation EDN1 EDN2 10217659 608432 Role of in deterioration of heart failure due to cardiomyopathy in hamsters : *increase* in [endothelin-1] production in the heart and beneficial effect of endothelin-A receptor antagonist on survival and cardiac function . Negative_regulation EDN1 EDN2 1659343 171315 In competition experiments , [ 125I ] [ET-1] binding was totally *inhibited* by unlabeled ET-1 and with inhibition constant ( Ki ) values of 0.20 and 0.21 nM respectively , and 80 % inhibited by ET-3 with Ki value of 0.50 nM . Negative_regulation EDN1 EDN2 17660396 1799075 Altered *role* of smooth muscle receptors in coronary [endothelin-1] and alpha1-adrenoceptor mediated vasoconstriction in Type 2 diabetes . Negative_regulation EDN1 EDN2 2161792 133575 Unlabeled ET-1 and preferentially *down-regulated* the binding of [ 125I ] [ET-1] , and S6b preferentially down-regulated the binding of [ 125I ] S6b. ( ABSTRACT TRUNCATED AT 250 WORDS ) Negative_regulation EDN1 EDN2 2166046 137882 Binding of [125I-ET-1] to these cells was *inhibited* by 50-200 pM , whereas endothelin-3 did not compete for this receptor subtype . Negative_regulation EDN1 EDN2 7806063 292503 Unlabeled ET-1 , , and ET-3 *inhibited* the specific binding of [125I-ET-1] in a concentration dependent manner , but the inhibitory effect of ET-3 was smaller than those of ET-1 and ET-2 . Negative_regulation EDN1 EDN2 7900824 300113 The binding of [125I-ET-1] to these cells was *inhibited* by the presence of unlabeled ET-1 , , or BQ-123 , whereas ET-3 and sarafotoxin S6c did not compete for this binding site . Negative_regulation EDN1 EDN2 8751073 344182 ET-1 and *inhibited* [ 125I ] [ET-1] binding to the membrane particulates from the various regions of the urinary tract with single high affinity constants . Negative_regulation EDN1 EDN2 9770328 538816 [ET-1] binding was completely *inhibited* by unlabelled ET-1 or , and by BQ123 ( ETA receptor antagonist ) , whereas ET-3 and IRL1038 ( ETB receptor antagonist ) did so only weakly . Negative_regulation EDN1 EPHB2 19575782 2111409 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Negative_regulation EDN1 IL1B 12239089 989289 The activities of ERalpha and ERbeta were compared in three distinct gene regulatory pathways , including inhibition of induction of E-selectin expression , *inhibition* of basal [endothelin-1] production , and the ability to induce two matrix stabilizing enzymes : tissue transglutaminase and a novel member of the lysyl oxidase family . Negative_regulation EDN1 IL1B 9252556 447583 *inhibits* [ET-1] production by ATII cells in vitro : evidence for involvement of cyclooxygenase 2 pathway . Negative_regulation EDN1 TNF 10218741 608493 Stimulation of BAECs with or transforming growth factor-beta increased ET-1 synthesis , and treatment of BAECs with 2-chloroadenosine or staurosporine *caused* concentration dependent reductions in [ET-1] synthesis . Negative_regulation EDN1 TNF 15652492 1364256 H ( 2 ) O ( 2 ) enhances induced IL-8 expression , but *inhibits* TNF-alpha induced [ET-1] expression . Negative_regulation EDN1 TNF 20193475 2216303 Our results indicate that the selective ET-1R antagonist BQ123 not only reduces the increase of mPAP and serum [ET-1] level , but also *inhibits* the production of , and attenuates the local inflammatory response induced by APTE . Negative_regulation EDN1 TNF 22249931 2569492 Bosentan , an endothelin receptor antagonist , ameliorates collagen induced arthritis : the *role* of in the induction of [endothelin] system genes . Negative_regulation EDN2 ACE 8707380 376347 Comparison of effect of [endothelin] antagonism and *inhibition* on blood pressure and vascular structure in spontaneously hypertensive rats treated with N omega-nitro-L-arginine methyl ester . Negative_regulation EDN2 ACE 9595459 506035 Effects of [endothelin] receptor antagonism and *inhibition* on cardiac and renal remodeling in the rat . Negative_regulation EDN2 APOB 8929252 386378 Extensively oxidized *inhibited* [endothelin] secretion from cultured endothelial cells . Negative_regulation EDN2 ATP5O 1662089 172730 From these data , it was concluded that [endothelin] inhibits fluid and bicarbonate transport in the proximal tubule and that this inhibition is in part *due* to suppression of Na+/K+ activity . Negative_regulation EDN2 BMP7 11786084 901235 *represses* the basal and TNF-alpha stimulated expression of the pro-inflammatory cytokines IL-6 and IL-1beta , the chemokines MCP-1 and IL-8 , and the vasoconstrictor [ET-2] in PTEC . Negative_regulation EDN2 CA2 2674497 117776 [Endothelin] *induced* rapid increase followed by a decrease in cytosolic [ ( Ca2+ ] i ) and a slow increase in muscle tension in the vascular smooth muscle strip of rat carotid artery . Negative_regulation EDN2 CAV1 20026011 2200264 The *role* of beta ( 1 ) interaction in [endothelin] signaling through Galpha subunits . Negative_regulation EDN2 CCL2 22262076 2520544 Novel interventions , which are reviewed here , include vitamin D receptor activators , RAASi with direct renin *inhibitors* or aldosterone antagonists , [endothelin-antagonist] , inflammation suppression with pentoxyfillin , synthesis inhibitors , or with Nrf2 agonists . Negative_regulation EDN2 CD28 15347370 1292241 Activation by sIgA and ligation *resulted* in the release of ECP and [EDN] , which was inhibited by IPD-1151T . Negative_regulation EDN2 EDN1 10573185 568766 Specifically , acute hypoxic stress *induced* a significant increase ( 360 % of the basal level ) in [ET-2] mRNA expression compared with that in normoxic cells , whereas it decreased mRNA expression by 62 % in primary cultured cardiomyocytes . Negative_regulation EDN2 EDN1 8884216 391001 These findings indicate that 1 ) [endothelin] receptor blockade produces beneficial effects on renal haemodynamics in rats with experimental congestive heart failure and 2 ) may be *involved* in the pathogenesis of renal hypoperfusion only in decompensated congestive heart failure . Negative_regulation EDN2 EDNRB 21801593 2462231 Whether this effect was due to activation of [endothelin] A receptors in the *presence* of blockade or due to the loss of vasculoprotective effects of endothelin B receptors remained unknown . Negative_regulation EDN2 EDNRB 8587353 341642 *mediated* contraction of human and rat pulmonary resistance arteries and the effect of pulmonary hypertension on [endothelin] responses in the rat . Negative_regulation EDN2 EGF 1722462 173612 specifically *reduced* the secretion of not only ir-ET-2 but also ir-big [ET-2] with only a small decrease in total protein synthesis . Negative_regulation EDN2 EPHB2 19575782 2111423 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Negative_regulation EDN2 FAS 22972036 2706274 By real-time RT-PCR analysis , ET-2 mRNA expression was found to significantly increase in cultured ovarian GCs after treatment with hCG , or even N-carbobenzoxyl-L-leucinyl-L-leucinyl-L-norvalinal ( MG-132 ) , while this increased [ET-2] mRNA expression could also be *blocked* by under human chorionic gonadotropin ( hCG ) treatment . Negative_regulation EDN2 GATA2 19279013 2063577 silencing of *resulted* in diminished expression of [EDN] , and also diminished expression of GATA-1 in both butyric acid induced HL-60 clone 15 cells and in differentiating human eosinophils derived from CD34 ( + ) hematopoietic progenitors . Negative_regulation EDN2 GATA2 19279013 2063584 Likewise , overexpression of in uninduced HL-60 clone 15 cells *resulted* in augmented transcription of both [EDN] and GATA-1 . Negative_regulation EDN2 HGF 18622140 1984413 Taken together , these data suggest that in asthma , *attenuates* allergic airway inflammation and AHR through at least the suppression of ROS production and [EDN] release from eosinophils . Negative_regulation EDN2 IFNG 2104901 126868 However , *suppressed* sIgA induced [EDN] release by 23 % . Negative_regulation EDN2 IL6 11997273 939330 [Endothelin] antagonism and *inhibition* attenuate the proatherogenic effects of C-reactive protein . Negative_regulation EDN2 IL6 11997273 939336 In each study , the effect of [endothelin] antagonism ( bosentan ) and *inhibition* ( monoclonal anti-IL-6 antibodies ) was examined . Negative_regulation EDN2 INS 8674895 372459 Insulin at a concentration in the physiological range ( 10 ( -10 ) -10 ( -7 ) mol/l ) potently suppressed CNP secretion , whereas at the same concentration did not *suppress* [endothelin (ET)] secretion from EC . Negative_regulation EDN2 MAPK1 19575782 2111424 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Negative_regulation EDN2 MAPK10 19575782 2111425 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Negative_regulation EDN2 MAPK11 19575782 2111426 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Negative_regulation EDN2 MAPK12 19575782 2111427 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Negative_regulation EDN2 MAPK13 19575782 2111428 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Negative_regulation EDN2 MAPK14 19575782 2111429 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Negative_regulation EDN2 MAPK15 19575782 2111422 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Negative_regulation EDN2 MAPK3 19575782 2111430 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Negative_regulation EDN2 MAPK4 19575782 2111431 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Negative_regulation EDN2 MAPK6 19575782 2111432 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Negative_regulation EDN2 MAPK7 19575782 2111433 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Negative_regulation EDN2 MAPK8 19575782 2111434 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Negative_regulation EDN2 MAPK9 19575782 2111435 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Negative_regulation EDN2 MME 11566914 863976 We showed that the inhibition of does not *augment* the vasodilator and vasoconstrictor activities of adrenomedullin and [endothelin] , respectively , in small resistance arteries from patients with chronic heart failure . Negative_regulation EDN2 MME 1535677 190967 inhibition *increases* the urinary excretion and plasma levels of [endothelin] . Negative_regulation EDN2 NDP 23009755 2720189 Constitutive overexpression of *activates* Wnt/ß-catenin and [endothelin-2] signaling to protect photoreceptors from light damage . Negative_regulation EDN2 NFKB1 19616538 2124173 Ghrelin also significantly suppressed interleukin-1beta , tumor necrosis factor-alpha , and [endothelin-l] mRNA expression , and *inhibited* activation . Negative_regulation EDN2 NOS1 15126084 1244689 In some experiments , the effects of [endothelin (ET)] receptor blockade ( with bosentan ) and *inhibition* ( with L-NAME ) on pravastatin mediated cardioprotection were evaluated . Negative_regulation EDN2 NOS1 9578518 503272 *Role* of in release of [endothelin] from cultured human endometrial cells . Negative_regulation EDN2 NOS2 9578518 503273 *Role* of in release of [endothelin] from cultured human endometrial cells . Negative_regulation EDN2 NOS3 18043518 1846634 PPHN was associated with decreases in and ET-B receptor and *increase* in [prepro-endothelin] mRNA levels . Negative_regulation EDN2 NOS3 9578518 503274 *Role* of in release of [endothelin] from cultured human endometrial cells . Negative_regulation EDN2 NPPA 21694921 2185189 Reductions of Mg and can *trigger* pronounced angiotensin ( 200 % ) , [endothelin] , and catecholamine elevations ( clearly shown in recent years ) and vicious cycles between the latter and Mg deficits . Negative_regulation EDN2 PPP3CA 15619133 1348842 In 11 renal transplant patients , blood CsA concentrations , *inhibition* in peripheral blood mononuclear cells and [endothelin] plasma concentrations were measured over a 4-h period after CsA intake . Negative_regulation EDN2 PPP3R1 15619133 1348843 In 11 renal transplant patients , blood CsA concentrations , *inhibition* in peripheral blood mononuclear cells and [endothelin] plasma concentrations were measured over a 4-h period after CsA intake . Negative_regulation EDN2 PRCC 15139053 1246999 The presence of ECE-1 mRNA in these tissue specimens suggested that active endothelin ligands were present , indicating [endothelin] axis activity was elevated in ccRCC compared with normal kidney , but *impaired* in . Negative_regulation EDN2 RELA 19616538 2124174 Ghrelin also significantly suppressed interleukin-1beta , tumor necrosis factor-alpha , and [endothelin-l] mRNA expression , and *inhibited* activation . Negative_regulation EDN2 REN 19376621 2135556 [Endothelin] receptor antagonism and *inhibition* as treatment options for scleroderma kidney . Negative_regulation EDN2 REN 19376621 2135562 Both [endothelin] receptor antagonism and direct *inhibition* offer alternate novel therapies for patients with SRC . Negative_regulation EDN2 REN 8682065 343267 Novel possibilities that have not yet been tested sufficiently in patients with heart failure include [endothelin] receptor antagonism , arginine vasopressin antagonism , and *inhibition* . Negative_regulation EDN2 SERPINE1 16264199 1478715 Blood was taken prior to PCI for baseline measurement of : ( 1 ) vasoconstrictive factors : [endothelin (ET)] and serotonin ( 5-HT); (2 ) thrombotic factors : tissue factor ( TF ) , plasminogen activator *inhibitor* ( ) , thrombin/antithrombin III complex (TAT) , and prothrombin fragment F1+2 ( F1+2 ) ; Negative_regulation EDN2 SLC33A1 8903630 344926 Our data show that chronic receptor blockade does not modify plasma endothelin-like immunoreactivity but *increases* urinary [endothelin-like] immunoreactivity . Negative_regulation EDN2 TGFB1 16255956 1477500 The procedure was also performed in the presence or absence of [endothelin (ET)] receptor A *inhibitor* ( BQ123 ) , ( TGF-beta(1) ) neutralized antibody , respectively or simultaneously , followed by immunostaining , Western blotting and bromodeoxyuridine ( BrdU ) incorporation respectively to detect alpha-SMA expression and cell proliferation in the co-cultured sub-epithelial fibroblasts . Negative_regulation EDN2 TGFB1 1722462 173609 Production of immunoreactive ( ir- ) [endothelin-2 (ET-2)] in renal adenocarcinoma cells , ACHN , was *reduced* by , basic fibroblast growth factor , transforming growth factor-alpha and , most strikingly , by epidermal growth factor (EGF) . Negative_regulation EDN2 TGFB2 1722462 173610 Production of immunoreactive ( ir- ) [endothelin-2 (ET-2)] in renal adenocarcinoma cells , ACHN , was *reduced* by , basic fibroblast growth factor , transforming growth factor-alpha and , most strikingly , by epidermal growth factor (EGF) . Negative_regulation EDN2 TGFB3 1722462 173611 Production of immunoreactive ( ir- ) [endothelin-2 (ET-2)] in renal adenocarcinoma cells , ACHN , was *reduced* by , basic fibroblast growth factor , transforming growth factor-alpha and , most strikingly , by epidermal growth factor (EGF) . Negative_regulation EDN2 TNF 22249931 2569493 Bosentan , an endothelin receptor antagonist , ameliorates collagen induced arthritis : the *role* of in the induction of [endothelin] system genes . Negative_regulation EDN2 TSLP 22838633 2640772 stimulation *resulted* in release of [EDN] , phosphorylation of STAT5 as well as promotion of viability and survival . Negative_regulation EDN2 VEGFA 23614848 2774839 Apelin is an adipokine that elicits endothelium dependent vasorelaxation and reduces arterial blood pressure , while relaxin is a protein hormone that induces the production of nitric oxide and and *inhibits* [endothelin] and angiotensin II . Negative_regulation EDN3 EPHB2 19575782 2111437 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Negative_regulation EDN3 TNF 22249931 2569494 Bosentan , an endothelin receptor antagonist , ameliorates collagen induced arthritis : the *role* of in the induction of [endothelin] system genes . Negative_regulation EDNRB EDN2 1321607 190259 Using ROS17/2 rat osteosarcoma cells as a model system , we examined the possibility that *induced* down-regulation of [ETB] receptor was accompanied by a decrease in levels of ETB receptor mRNA . Negative_regulation EEC1 FAS 18342935 1886517 Since Fas and Fas ligand (FasL) are expressed in EEC and trophoblast cells respectively and mitogen activated protein kinases ( MAPKs ) mediate Fas induced apoptosis , the *roles* of and MAPK signaling in [trophoblast-EEC] interactions were studied . Negative_regulation EEF2K TNF 12171600 992515 Since the phosphorylation of Ser-377 does not inhibit eEF2 kinase in vitro , our results suggest that anisomycin or *inhibit* [eEF2 kinase] via the phosphorylation of Ser-359 . Negative_regulation EFNB1 JUNB 19193201 2007220 Over-expression of *down-regulated* PTHR1 and [ephrin B1] , and increased VCAM-1 . Negative_regulation EFNB1 WNT1 22227340 2550506 Activation of canonical signaling or *inhibition* of forward [EfnB] signaling rescues the eye defects caused by loss of ADAM13 , suggesting that ADAM13 functions through regulation of the EfnB-Wnt pathway interaction . Negative_regulation EFNB1 WNT11 22227340 2550507 Activation of canonical signaling or *inhibition* of forward [EfnB] signaling rescues the eye defects caused by loss of ADAM13 , suggesting that ADAM13 functions through regulation of the EfnB-Wnt pathway interaction . Negative_regulation EFNB1 WNT16 22227340 2550512 Activation of canonical signaling or *inhibition* of forward [EfnB] signaling rescues the eye defects caused by loss of ADAM13 , suggesting that ADAM13 functions through regulation of the EfnB-Wnt pathway interaction . Negative_regulation EFNB1 WNT2 22227340 2550508 Activation of canonical signaling or *inhibition* of forward [EfnB] signaling rescues the eye defects caused by loss of ADAM13 , suggesting that ADAM13 functions through regulation of the EfnB-Wnt pathway interaction . Negative_regulation EFNB1 WNT3 22227340 2550509 Activation of canonical signaling or *inhibition* of forward [EfnB] signaling rescues the eye defects caused by loss of ADAM13 , suggesting that ADAM13 functions through regulation of the EfnB-Wnt pathway interaction . Negative_regulation EFNB1 WNT4 22227340 2550510 Activation of canonical signaling or *inhibition* of forward [EfnB] signaling rescues the eye defects caused by loss of ADAM13 , suggesting that ADAM13 functions through regulation of the EfnB-Wnt pathway interaction . Negative_regulation EFNB1 WNT6 22227340 2550511 Activation of canonical signaling or *inhibition* of forward [EfnB] signaling rescues the eye defects caused by loss of ADAM13 , suggesting that ADAM13 functions through regulation of the EfnB-Wnt pathway interaction . Negative_regulation EFS IL1B 16675961 1583969 Concomitantly , we demonstrated that [EFs] stimulation *induced* NF-kappaB nuclear translocation and DNA binding on IL-1beta promoter region whereas inhibition of NF-kappaB with the specific chemical inhibitor SN-50 or by overexpression of IkappaB , the endogenous inhibitor of NF-kappaB pathway , totally abolished EFs mediated mRNA overexpression . Negative_regulation EGF ADAMTS1 16314835 1546921 Overexpression of in these cells *promoted* tumor angiogenesis and invasion , shedding of the transmembrane precursors of heparin binding epidermal growth factor (EGF) and amphiregulin (AR) , and activation of the [EGF] receptor and ErbB-2 , while overexpression of ADAMTS-1E/Q inhibited these events . Negative_regulation EGF CCND1 11123423 762769 [EGF] *induced* cell proliferation through ERK phosphorylation , since U0126 , which is an inhibitor of ERK phosphorylation , abrogated the increase of by EGF . Negative_regulation EGF EPHB2 10688043 669950 Inhibition of [EGF-] and LPA- *induced* activation with the EGF receptor inhibitor , AG1478 , or the MEK inhibitor , PD98059 , attenuated their proliferative effects . Negative_regulation EGF EPHB2 15908804 1420111 [EGF] *induced* a mild effect on DNA synthesis and activation in EGFR positive FDC-P1 cells but not EGFR negative FL5.12 cells . Negative_regulation EGF EPHB2 21518868 2428884 EGF activates NF-?B and *stimulates* phosphorylation of FER , [EGF receptor (EGFR)] , and ERK p42/p44 , and decreased expression of FER or inhibition of phosphorylation inhibits the EGF induced activation of NF-?B . Negative_regulation EGF HBEGF 11116149 810663 BB2116 as well as HB-EGF neutralizing antibody inhibited the EGF receptor transactivation by AngII , suggesting a critical *role* of in the metalloprotease dependent [EGF] receptor transactivation . Negative_regulation EGF HBEGF 1556128 184403 Heparin binding epidermal growth factor-like growth factor ( ) is a newly described member of the epidermal growth factor (EGF) family that is mitogenic for BALB/c 3T3 cells , *inhibits* the binding of [125I-EGF] to its receptor , and triggers autophosphorylation of the EGF receptor . Negative_regulation EGF HBEGF 20586269 2280653 H2O2 induced [EGF] receptor phosphorylation was *inhibited* by , but not TGF-alpha , neutralizing antibody . Negative_regulation EGF IGFBP1 16701564 1563851 *inhibits* [EGF] mitogenic activity in cultured endometrial stromal cells . Negative_regulation EGF MAP2K6 12037663 949281 The *activation* of hTERT mRNA expression by [EGF] was specifically blocked by inhibitor , and in vitro kinase assays demonstrated that ERK is activated in response to EGF . Negative_regulation EGF MAP2K6 9448004 483768 Activated forms of Ras , RacI , Cdc42Hs , and MEKK increased expression of the c-jun promoter , while dominant negative forms of Ras , RacI , and *inhibited* [EGF] induction . Negative_regulation EGF RARB 15766561 1383686 An [EGF] receptor inhibitor *induces* expression in breast and ovarian cancer cells . Negative_regulation EGF TNF 14667973 1178037 Treatment with P4 augmented [EGF] and Bcl-2 protein expression , but *inhibited* IGF-I and expression in cultured leiomyoma cells . Negative_regulation EGF TNF 18467504 1944662 *inhibits* ligand stimulated [EGF] receptor activation through a TNF receptor 1-dependent mechanism . Negative_regulation EGF TNF 2334431 132637 *caused* an inhibition of 125I labeled [epidermal growth factor] [ ( 125I ] EGF ) binding to its receptors of human amniotic ( WISH ) cells at 5 min after addition of TNF , which reached a maximal level ( 60-70 % reduction ) after 15-30 min and declined thereafter . Negative_regulation EGF TNF 2334431 132638 however , still *reduced* the [EGF] binding to the cells pretreated with TPA for a long time . Negative_regulation EGF TNF 3259236 92886 We have previously shown that can *increase* the number of [epidermal growth factor (EGF)] receptors on human FS-4 fibroblasts and that this increase may be related to the mitogenic action of TNF in these cells . Negative_regulation EGF TNF 3546282 70421 *increases* the number of [epidermal growth factor] receptors on human fibroblasts . Negative_regulation EGFR CCND1 11751523 889948 Treatment with EGCG inhibited phosphorylation of the [EGFR] , signal transducer and activator of transcription3 ( Stat3 ) , and extracellular regulated kinase (ERK) proteins and also *inhibited* basal and transforming growth factor-alpha stimulated c-fos and promoter activity . Negative_regulation EGFR CCND1 24486412 2923600 Transfection of HIF-2a siRNA into HCC cells downregulated the expression of VEGF ( vascular endothelial growth factor ) , , HIF-2a and TGF-a , and *inhibited* the activation of [EGFR] . Negative_regulation EGFR EPHB2 11371939 817733 Inhibition of the kinase activity of protein kinase C or [epidermal growth factor receptor] eliminated BK *induced* activation . Negative_regulation EGFR EPHB2 12186792 978306 In VSMCs , EGFR-AS ( 2.5 micromol/L ) reduced [EGFR] expression and *inhibited* the Ang II-induced phosphorylation of . Negative_regulation EGFR EPHB2 14645669 1173053 However , long-term application of U69 ,593 neither down-regulated [EGFR] nor *inhibited* EGF induced activation . Negative_regulation EGFR EPHB2 19222789 2100041 In addition , ERK or AKT activation is essential for EGFR activation because or AKT inhibitor *blocks* [EGFR] activation following UVB radiation , indicating that EGFR/AKT/ERK pathways form a regulatory loop and converge into cell cycle progression following UVB radiation . Negative_regulation EGFR EPHB2 19956829 2184945 PCNA expression correlated with pathway inhibition , but not with gefitinib mediated *inhibition* of [EGFR] activity alone . Negative_regulation EGFR EPHB2 20562913 2308827 Next , we show that pharmacological inhibition of ( but not Akt ) signaling *enhances* EGF induced [EGFR] activation , ubiquitination and downregulation , and may lead to enhanced receptor turnover . Negative_regulation EGFR EPHB2 22418433 2587969 S2R ( Pgrmc1 ) associates with EGFR and *increases* [EGFR] levels at the plasma membrane , and the EGFR inhibitors erlotinib and AG1478 , as well as Akt and inhibitors , suppressed the NGAL/LCN2 RNA and protein levels . Negative_regulation EGFR FAS 19141676 2025740 No significant genetic interactions were detected with the Notch , Wingless , Hedgehog or Dpp pathways , nor did Fas2 inhibit the FGF receptor or Torso , indicating specificity in the inhibitory *role* of in [EGFR] signalling . Negative_regulation EGFR HBEGF 16153425 1455323 [EGFR] phosphorylation by plasmin was *blocked* by inhibition of MMP activity and the ligand . Negative_regulation EGFR HBEGF 17001310 1716323 Induction of HB-EGF expression and ectodomain shedding synergistically led to robust epidermal growth factor receptor (EGFR) phosphorylation , whereas inhibition of expression by use of the HB-EGF inhibitor ( CRM197 ) or siRNA *resulted* in the suppression of chemotherapy induced [EGFR] phosphorylation . Negative_regulation EGFR HBEGF 18656632 1942633 [EGFR] phosphorylation by insulin was *blocked* by inhibition of MMP activity and the ligand . Negative_regulation EGFR HBEGF 19040574 1998783 Treatment of clones with heparin binding epidermal growth factor (EGF)-like growth factor ( ) neutralizing antibodies as well as an [EGFR] *inhibitor* allowed the dissection of mechanisms regulating cell proliferation and apoptosis . Negative_regulation EGFR HBEGF 19394555 2070220 [EGFR] phosphorylation by ATF was *blocked* by inhibition of MMP activity and the ligand . Negative_regulation EGFR HBEGF 23349960 2734138 Erlotinib blocks the activation of the [epidermal growth factor receptor (EGFR)] in *response* to . Negative_regulation EGFR HBEGF 23451083 2749374 Both telmisartan and candesartan did not inhibit TPA induced [EGFR] phosphorylation , and telmisartan , but not candesartan , *inhibited* TPA induced nuclear translocation of after knockdown of AT1R . Negative_regulation EGFR ID1 14688027 1218833 In contrast , down-regulation of in androgen independent DU145 cells by its antisense oligonucleotides *resulted* in suppression of [EGF-R] expression at both transcriptional and protein levels . Negative_regulation EGFR MAP2K6 15177934 1255127 The effects of NT on [EGFR/ERK/Akt] activation and DNA synthesis were *attenuated* by PLC-inhibitor ( U73122 ) , PKC-inhibitors ( bisindolylmaleimide , staurosporine , rottlerin ) , inhibitor ( U0126 ) and PI3 kinase inhibitors ( wortmannin , LY 294002 ) . Negative_regulation EGFR MAP2K6 22546605 2602978 Both claudin-2 and p-ERK1/2 levels were decreased by EGF neutralizing antibody , EGF receptor (EGFR) siRNA , AG1478 , an *inhibitor* of [EGFR] , U0126 , an inhibitor of MEK , and the exogenous expression of dominant . Negative_regulation EGFR MAP2K6 8662819 367328 *Role* of in regulation of the [epidermal growth factor receptor] by protein kinase C . Negative_regulation EGFR MMP28 17149366 1661623 Inhibition of activity *leads* to decreased [EGFR] phosphorylation . Negative_regulation EGFR MMP7 17149366 1661638 Inhibition of activity *leads* to decreased [EGFR] phosphorylation . Negative_regulation EGFR MUC16 21326240 2403905 Downregulation of cell surface induces epithelial-to-mesenchymal transition and *restores* [EGFR] signalling in NIH : OVCAR3 ovarian carcinoma cells . Negative_regulation EGFR RARB 17286282 1718475 The [ErbB-1] inhibitor PD153035 cooperates with retinoic acid during growth inhibition and *induces* suggesting that ErbB-1 controls retinoic acid receptor-beta . Negative_regulation EGFR TNF 10023672 590678 Prior to the onset of apoptosis , caused a significant reduction in the level of EGFr tyrosine phosphorylation in Sen cells but *mediated* only limited suppression of [EGFr] tyrosine phosphorylation in apoptotically resistant Res cells . Negative_regulation EGFR TNF 18467504 1944663 *attenuated* EGF stimulated [EGFR] phosphorylation in wild-type and TNFR2 ( -/- ) , but not TNFR1 ( -/- ) , mouse colon epithelial ( MCE ) cells . Negative_regulation EGFR TNF 18467504 1944665 Reexpression of wild-type TNFR1 in TNFR1 ( -/- ) MCE cells rescued *induced* [EGFR] inhibition , but expression of TNFR1 deletion mutant constructs lacking the death domain ( DD ) of TNFR1 did not , implicating this domain in EGFR downregulation . Negative_regulation EGFR TNF 18701712 1950523 stimulated EGFR phosphorylation in young adult mouse colon epithelial cells , and loss of [EGFR] expression or inhibition of kinase activity *increased* TNF induced apoptosis , which was prevented in WT but not by kinase-inactive EGFR expression . Negative_regulation EGFR TNF 22223859 2559151 Further studies showed that decreased expression of the antiapoptotic proteins Bcl-2 and Bcl-xL , decreased I?Ba and PPAR? , and also *inhibited* PI3K dependent Akt and [EGFR] signaling . Negative_regulation EGFR TNF 9098007 422658 *inhibited* the mitogenic effect of growth factors and [epidermal growth factor receptor] tyrosine phosphorylation . Negative_regulation EGLN1 ANGPT1 23616286 2795383 *dependent* [Phd2] repression initiated a feed-forward loop mediated by the induction of the ANG receptor TIE2 in macrophages . Negative_regulation EGLN1 CLU 24105925 2896369 Inhibition of [PHD-2] with shRNAs *increased* postischemic neovascularization in diabetic mice with . Negative_regulation EGLN1 EGLN3 14506252 1164839 Interestingly , [EGLN1] and EGLN3 mRNAs were also *triggered* by inhibitors , suggesting the involvement of HIFalpha in the control of its transcription . Negative_regulation EGLN3 ANGPT2 15308873 1290466 The present study was undertaken to investigate whether the *mediated* suppression of [SM-20/PHD3/PHD3] may be associated with an increase in HIF-1 alpha . Negative_regulation EGLN3 EGLN1 14506252 1164840 Interestingly , EGLN1 and [EGLN3] mRNAs were also *triggered* by inhibitors , suggesting the involvement of HIFalpha in the control of its transcription . Negative_regulation EGLN3 EGLN2 14506252 1164841 Interestingly , EGLN1 and [EGLN3] mRNAs were also *triggered* by inhibitors , suggesting the involvement of HIFalpha in the control of its transcription . Negative_regulation EGLN3 EGLN3 14506252 1164842 Interestingly , EGLN1 and [EGLN3] mRNAs were also *triggered* by inhibitors , suggesting the involvement of HIFalpha in the control of its transcription . Negative_regulation EGLN3 EPAS1 15156561 1250495 We further tested the regulation of these genes by HIF-1 and HIF-2 and found that siRNA targeted degradation of HIF-1alpha and *results* in decreased hypoxia induced [PHD3] expression . Negative_regulation EGLN3 HIF1A 15104534 1272932 In the human osteosarcoma cell line , U2OS , selective suppression of expression by RNA interference *resulted* in a complete loss of hypoxic induction of PHD2 and [PHD3] . Negative_regulation EGLN3 HIF1A 15156561 1250496 We further tested the regulation of these genes by HIF-1 and HIF-2 and found that siRNA targeted degradation of and HIF-2alpha *results* in decreased hypoxia induced [PHD3] expression . Negative_regulation EGLN3 SETD2 24477694 2913241 [PHD3] expression was *inhibited* by blockade of Akt and mammalian target of rapamycin (mTOR) , but not by and HIF-2a double knockdown . Negative_regulation EGLN3 SLC22A3 24367580 2881794 We also found that induction of in MDCK cells *resulted* in the specific downregulation of [PHD3] , whereas the expression of the other HIF-PHD enzymes was not affected . Negative_regulation EGR1 EPHB2 16551742 1542078 In RAW macrophages in vitro , hypoxia induced Egr-1 mRNA expression was ERK dependent , and CO-mediated suppression of activation *resulted* in [Egr-1] inhibition . Negative_regulation EGR1 EPHB2 22198386 2575040 We demonstrate that induction of [EGR1] *involves* mediated down-regulation of microRNA-191 and phosphorylation of the ETS2 repressor factor (ERF) repressor , which subsequently leaves the nucleus . Negative_regulation EGR1 RCAN1 24218457 2879488 Interestingly , SCF induced [Egr1] was also *suppressed* by , suggesting a negative regulatory loop between Egr1 and Rcan1 . Negative_regulation EGR1 TNF 9437186 474866 The present studies are the first to demonstrate that PMA , but not LPS , , and thrombin , induced Egr-1 binding to the second serum-responsive region ( SRR-2 ) of TF promoter and that curcumin *inhibited* the PMA induced [Egr-1] binding to SRR-2 . Negative_regulation EIF1AX TNF 15967409 1428231 These data indicate that a ARE binding trans acting factor ( s ) *inhibits* the association of the [43S complex] with RNA transcripts . Negative_regulation EIF2AK2 LBP 17611646 1768652 markedly *reduced* the phosphorylation of [PKR] triggered by A beta peptide . Negative_regulation EIF2AK2 MAP2K6 16414988 1514480 Activated *suppresses* activation of [PKR] and enables efficient replication and in vivo oncolysis by Deltagamma ( 1 ) 34.5 mutants of herpes simplex virus 1 . Negative_regulation EIF2AK2 MAP2K6 16414988 1514487 The results indicate that activated *mediates* the suppression of [PKR] and that the status of MEK predicts the ability of Deltagamma ( 1 ) 34.5 mutant viruses to replicate in and destroy tumor cells . Negative_regulation EIF2AK2 MAP2K6 17927520 1813178 Tumor cells which overexpress MAPK kinase ( MEK ) activity support robust replication of Deltagamma134.5 mutants via mediated *inhibition* of [PKR] , resulting in tumor oncolysis . Negative_regulation EIF2AK2 MAP2K6 23302873 2742264 Earlier studies have shown that active *blocks* the activation of [protein kinase R (PKR)] , a component of antiviral innate immune responses . Negative_regulation EIF2AK2 TNF 16153435 1455348 Inhibition of expression by tetracycline *resulted* in downregulation of [PKR] and decreased apoptosis . Negative_regulation EIF2S1 FAS 10908726 715703 We now show that activation of the receptor *promotes* an early , transient increase in the level of [eIF2alpha] phosphorylation , which is temporally correlated with the onset of the inhibition of translation . Negative_regulation EIF2S1 TLR7 19855386 2165515 engagement did not *suppress* phosphorylation of PERK or [eIF-2alpha] , which are upstream of CHOP , but phospho-eIF-2alpha failed to promote translation of the CHOP activator ATF4 . Negative_regulation EIF4EBP1 MAP2K6 11799119 922294 Overexpression of constitutively active in HEK293 cells *resulted* both in the phosphorylation of [4E-BP1] at Ser ( 64 ) and Thr ( 36/45 ) and its release from eIF4E . Negative_regulation EIF4EBP1 TNF 22266196 2559752 DAG also reversed or attenuated the *induced* reduction in phosphorylation of Akt , FOXO1 , [4E-BP-1] , and GSK-3ß in myotubes . Negative_regulation EIF4G1 CAPN8 22006312 2503271 Finally , inhibition following global ischemia in vivo *blocked* decreases in [eIF4G1] , facilitated protein synthesis , and increased neuronal viability in ischemia-vulnerable hippocampal CA1 neurons . Negative_regulation EIF4G1 EPHB2 11154262 770699 Interestingly , we found that the association of both Mnk1 and Mnk2 with eIF4G increased upon inhibition of the MAPK pathways while activation of *resulted* in decreased binding to [eIF4G] . Negative_regulation EIF4G2 EPHB2 11154262 770700 Interestingly , we found that the association of both Mnk1 and Mnk2 with eIF4G increased upon inhibition of the MAPK pathways while activation of *resulted* in decreased binding to [eIF4G] . Negative_regulation EIF4G3 EPHB2 11154262 770701 Interestingly , we found that the association of both Mnk1 and Mnk2 with eIF4G increased upon inhibition of the MAPK pathways while activation of *resulted* in decreased binding to [eIF4G] . Negative_regulation ELANE MUC16 7912511 261984 Human airway mucin and bovine submaxillary at concentrations of 0.4 to 2.8 mg/ml both markedly *inhibited* the elastolytic activity of 50 nM [HLE] , with maximum inhibition approaching 90 % . Negative_regulation ELANE TNF 9758732 536310 Methylprednisolone treatment effectively inhibited the increases in and IL-6 and the decreases in AT-III and albumin , but did not *inhibit* the increases in [PMN-elastase] and TAT levels . Negative_regulation ELAVL1 EPHB2 20161729 2215147 Berberine significantly inhibited HIV PI-induced TNF-alpha and IL-6 expression by modulating ER stress signaling pathways and subsequent activation , in turn *preventing* the accumulation of the RNA binding protein [HuR] in cytosol and inhibiting the binding of HuR to the 3'-UTRs of TNF-alpha and IL-6 in macrophages . Negative_regulation ELAVL1 EPHB2 23116706 2717445 Blocking signaling pathway activation *resulted* in attenuated [HuR] binding . Negative_regulation ELF3 FOXA1 23266329 2745807 KLF5 directly inhibited activity of the FoxA1 promoter , and in turn *inhibited* [Elf3] gene expression in vitro , linking the observed loss of Elf3 with the persistent expression of FoxA1 observed in Klf5-deficient mice . Negative_regulation ELL C1QTNF1 9002605 404750 The results of the present work support the possible *role* of in GA-induced corolla and stem [elongation] . Negative_regulation ELL EPHB2 15067199 1231863 Taken together , the results demonstrate the functional *role* for and p23 in the neurite [elongation] activity of FK506 and reveal a novel signal transduction pathway involving p23 activation of ERK . Negative_regulation ELL MAP2K6 15304225 1284539 Here , we tested this model , and we found that the capping function of HP1 is due to its direct binding to telomeric DNA , while the silencing of telomeric sequences and telomere [elongation] is *due* to its interaction with . Negative_regulation ELL MAP2K6 16463277 1534585 A detailed study of growth cone behavior showed that the filopodial [elongation] *induced* by inhibiting PI-3K , Akt , ROCK , and was achieved by increasing two motility parameters : the rate with which filopodia extend ( extension rate ) and the time that filopodia spend elongating . Negative_regulation ELL MAP2K6 20869211 2337199 Overexpression of the constitutive active form of *resulted* in significant [elongation] of dendrites in the melanoma cell line SK-mel-24 . Negative_regulation ELL PLAU 8933768 398230 In the form deprived eyes , *inhibited* vitreous depth and axial length [elongation] , but PAI-1 had no effect . Negative_regulation ELL RNASE1 11952127 930473 A tobacco S-like *inhibits* hyphal [elongation] of plant pathogens . Negative_regulation ELL RNASE1 2425351 60430 subsequent [elongation] is *inhibited* by aphidicolin but not by . Negative_regulation ELL RNASE7 11952127 930481 A tobacco S-like *inhibits* hyphal [elongation] of plant pathogens . Negative_regulation ELL TMOD1 11054557 745725 By binding to the N-terminus of tropomyosin (TM) and actin , *blocks* the [elongation] and depolymerization of the actin filaments at the pointed end . Negative_regulation ELL TMOD1 7798317 281081 In the absence of tropomyosin , acts as a `` leaky '' cap , partially *inhibiting* [elongation] and depolymerization at the pointed filament ends ( Kd for inhibition of elongation = 0.1-0.4 microM ) . Negative_regulation ELL TNF 11826115 909370 These results suggest that glia derived , as part of an injury or inflammatory process , can *inhibit* neurite [elongation] and branching during development and regeneration . Negative_regulation ELL TNF 9856801 555195 , however , strongly *inhibited* the [elongation] of the hair shaft in a dose dependent manner , accompanied by abnormal morphology and increased cell death in the bulb matrix cells . Negative_regulation ELN CLU 17872975 1818229 associates with altered elastic fibers in human photoaged skin and *prevents* [elastin] from ultraviolet induced aggregation in vitro . Negative_regulation ELN CTGF 18385064 1893051 Transfection of *blocked* TGF-beta2 mediated activation of [elastin] and ColVI but had no effect on MMP-2 and PAI-1 induction . Negative_regulation ELN TNF 10423400 632593 Fibroblast [tropoelastin] and alpha-smooth-muscle actin expression are *repressed* by particulate activated macrophage derived in experimental silicosis . Negative_regulation ELN TNF 7798617 281104 These results suggest that excess ( or other mediator ) produced in C3H/HeN skin ( but not C3H/HeJ skin ) in response to UVB exposure is *involved* in the mast cell increase and partial inhibition of [elastin] increase , but that neither these mediators nor mast cell products are important mediators for the chronic UVB induced increases in neutrophils , glycosaminoglycans , and collagen . Negative_regulation EMP1 CRK 19192109 2049504 On the basis of the importance of p38 mitogen activated protein kinase (MAPK) in endothelial responses to inflammatory stimuli , we sought to define the *role* of in [EMP] generation and function . Negative_regulation EMP1 IFNB1 15957513 1422672 MS-E but not MS-R plasma elicited release of activation derived EMP and enhanced TEMIG of mono and mono : EMP . 1b *inhibited* TEMIG and release of [EMP] , suggesting a role of EMP and a novel therapeutic mechanism for IFN-beta 1b in MS . Negative_regulation EMP1 ROCK2 16720831 1604878 Pharmacologic inhibition of Rho-kinases or specific depletion of by short interfering ( si ) RNA *inhibited* thrombin induced [EMP] release . Negative_regulation EMP1 TP53 12508535 1027476 Down-regulation of bcl-2 expression and up-regulation of expression were *induced* by [EMP] . Negative_regulation ENPP1 GALNT2 23500900 2766684 *Role* of in the modulation of [ENPP1] expression , and insulin signaling and action : GALNT2 : a novel modulator of insulin signaling . Negative_regulation ENPP1 SERPINE1 22553514 2366931 The corresponding gene expression and function can affect POAG progress , including *roles* of in extracellular matrix , [ENPP1] in insulin inhibition , IL-6 in endogenous neuroprotection , IL-6 , IL-6R and E-Sel in autoimmune response , LIPC and FGB in blood hyperviscosity syndrome , ADIPOQ in NOS/NO production , PON1 in vascular endothelial protection . Negative_regulation EPAS1 MUC16 1778417 175845 Apo- and holo-forms of HLf and BLf both inhibited more than 80 % , while *caused* approx. 50 % inhibition of the [HLf] binding . Negative_regulation EPAS1 TNF 23496259 2803950 However , *inhibited* the mRNA expression of the Per2 gene , as well as Dbp , [Hlf] , and Tef , but enhanced the mRNA expression of E4bp4 . Negative_regulation EPC1 ITGB2 16825578 1591412 Essential *role* of in mediating [EPC] recruitment , angiogenesis , and repair to the infarcted myocardium . Negative_regulation EPC2 ITGB2 16825578 1591414 Essential *role* of in mediating [EPC] recruitment , angiogenesis , and repair to the infarcted myocardium . Negative_regulation EPCAM TNF 11505407 847911 *induced* inhibition of the [EpCAM] expression is mediated by TNF receptor 1 through the TNF receptor associated death domain protein ( TRADD ) and by the activation of nuclear factor kappaB (NF-kappaB) , and it can be blocked by dominant negative variants of TRADD and the NF-kappaB inhibitor , IkappaB . Negative_regulation EPCAM ZFP57 17186549 1724586 Overall , are versatile bi-directional modulators of gene expression and downregulation of [EGP-2] promoter activity using ZFP-TFs can ultimately *result* in a novel anti-cancer treatment . Negative_regulation EPHA3 EPHB2 20434485 2274732 The results demonstrate that taspine can down-regulate phosphorylation of FGFR1 and , and *inhibit* [Hek293/FGFR1] and MCF-7 cell proliferation . Negative_regulation EPHA8 RINL 22291991 2545608 Interestingly , expression in cultured cells *reduced* [EphA8] levels in a manner dependent on both its GEF activity and interaction with odin . Negative_regulation EPHB2 ACE 16480696 1534741 inhibition *increased* bone marrow [ERK] phosphorylation and MMP-9 activity . Negative_regulation EPHB2 ACR 21071580 2371322 markedly *inhibited* the activation of Ras and phosphorylation of the [ERK] ( extracellular signal regulated kinase ) and RXRa proteins in the livers of experimental mice . Negative_regulation EPHB2 ACTL6A 20371669 2273394 Furthermore , treatment with 3MA markedly down-regulated capsaicin induced p38 activation and LC3 conversion , and completely *down-regulated* [ERK] activation and led to LC3II accumulation . Negative_regulation EPHB2 ACVRL1 17620321 1787019 Further , HMVEC-d wounding induced activation of both JNK and [ERK] , and these were *inhibited* by expression . Negative_regulation EPHB2 ADAP1 16287813 1509647 Here we have shown that transient expression of in COS-7 cells *results* in specific activation of [ERK] , and the activation is inhibited by co-expression of a dominant negative form of Ras . Negative_regulation EPHB2 ADAP1 16287813 1509649 We have also found that a mutant form of that is unable to bind PIP3 fails to induce ERK activation and that a phosphatidylinositol 3-kinase inhibitor LY294002 *inhibits* centaurin-alpha1 dependent [ERK] activation . Negative_regulation EPHB2 ADCY3 19070587 2018105 Furthermore , *dependent* inhibition of PDGF mediated [ERK-activation] and proliferation could be demonstrated . Negative_regulation EPHB2 ADCYAP1 12692897 1080611 C2-ceramide and *induced* opposite effects on phosphorylated forms of [ERK] and JNK without affecting the total amounts of ERK and JNK , suggesting that a balance between these two MAP-kinases is critical for the cell survival/death decision . Negative_regulation EPHB2 ADIPOQ 12070119 955783 also *reduced* PDGF-AA stimulated or HB-EGF stimulated [ERK] phosphorylation in a dose dependent manner without affecting autophosphorylation of PDGF alpha-receptor or EGF receptor . Negative_regulation EPHB2 ADIPOQ 15558058 1343415 In cultures of cardiac myocytes , activated AMPK and *inhibited* agonist stimulated hypertrophy and [ERK] activation . Negative_regulation EPHB2 ADIPOQ 18267956 1891135 also *suppressed* VEGF induced reactive oxygen species generation , activation of Akt , the mitogen activated protein kinase [ERK] and the RhoGTPase RhoA , and induction of the formation of actin stress fibres and focal cellular adhesions . Negative_regulation EPHB2 ADM 10666504 665623 Thus we conclude that the mechanism of *induced* decrease in [ERK] activity in rat mesangial cells is at least in part mediated by an increase in PP2A activity . Negative_regulation EPHB2 ADM 15511634 1328245 In contrast , *inhibited* aldosterone induced fibroblast proliferation and [ERK] activity . Negative_regulation EPHB2 ADM 18401334 1920304 In NRK-49F renal fibroblasts , reduced transforming growth factor-beta induced CTGF and fibronectin mRNA upregulation through the cyclic AMP/protein kinase A signaling pathway , and *suppressed* [ERK] phosphorylation and cell proliferation . Negative_regulation EPHB2 ADO 19070587 2018106 Furthermore , a dependent *inhibition* of PDGF mediated [ERK-activation] and proliferation could be demonstrated . Negative_regulation EPHB2 ADRBK1 10629859 576444 Expression of *inhibited* the H2O2 induced activation of [ERK] by 70 % and also inhibited the activation of Akt by 30 % . Negative_regulation EPHB2 ADRBK1 15671180 1369748 suppression actually *increased* beta-arrestin stimulated [ERK] activation . Negative_regulation EPHB2 ADRBK1 22509025 2589532 By suppressing GRK expression with siRNA , we demonstrated that lowering GRK5/6 abolishes IGF1 mediated ERK and AKT activation , whereas inhibition *increases* [ERK] activation and partially inhibits AKT signaling . Negative_regulation EPHB2 AGAP2 23527545 2787935 In addition , AGAP2 formed a complex with endogenous ERK ( extracellular-signal regulated kinase ) and overexpression of *potentiated* [ERK] phosphorylation induced by ß2-adrenergic receptors . Negative_regulation EPHB2 AGTR2 10406457 629406 Alanine substitutions further demonstrated that lysine 240 , asparagine 242 , and serine 243 are key residues for *induced* apoptosis , [ERK] inhibition , and SHP-1 activation . Negative_regulation EPHB2 AGTR2 10406457 629410 To examine whether a functional link exists between activation of SHP-1 and apoptosis , we used a catalytically inactive SHP-1 mutant and demonstrated that preventing SHP-1 activation strongly attenuates *induced* [ERK] inhibition and apoptosis . Negative_regulation EPHB2 AGTR2 10891597 711255 Angiotensin receptor stimulates ERK1 and ERK2 in quiescent but *inhibits* [ERK] in NGF stimulated PC12W cells . Negative_regulation EPHB2 AGTR2 11230986 789431 Transient transfection of a dominant negative SHP-1 mutant into rat fetal VSMCs resulted in a significant decrease of the receptor mediated *inhibition* of [ERK] phosphorylation and attenuated the proapoptotic effect of AT2 receptor . Negative_regulation EPHB2 AGTR2 11566906 863963 Maximal [ERK] activity induced by Ang II was *increased* 1.9- and 2.2-fold by inhibition , which was abolished by orthovanadate but not okadaic acid or pertussis toxin . Negative_regulation EPHB2 AGTR2 11566906 863968 Stable overexpression of SHP-1-dominant negative mutant completely abolished mediated *inhibition* of EGFR and [ERK] activation . Negative_regulation EPHB2 AGTR2 11566906 863969 These findings suggested that *inhibits* [ERK] activity by inducing SHP-1 activity , leading to decreases in AP-1 activity and AP-1 regulated gene expression , in which EGFR dephosphorylation plays an important role via association of SHP-1 . Negative_regulation EPHB2 AGTR2 9806232 544755 Moreover we observed that AT1 receptor stimulation activated extracellular signal regulated kinase ( ERK ) , whereas the receptor stimulation *inhibited* the activation of [ERK] . Negative_regulation EPHB2 AHR 24163404 2916325 Beta-naphthoflavone ( DB06732 ) mediates estrogen receptor positive breast cancer cell cycle arrest through *dependent* regulation of PI3K/AKT and [MAPK/ERK] signaling . Negative_regulation EPHB2 AHSA1 9553146 499563 The *activation* of and apoptosis by the inhibition of [Erk] is antagonized by the phosphoinositide 3-kinase/Akt pathway . Negative_regulation EPHB2 AIRE 18600064 1935488 Moreover , *inhibited* LPS induced [ERK] phosphorylation . Negative_regulation EPHB2 AKT1 10629859 576445 Expression of GRK2-ct inhibited the H2O2 induced activation of [ERK] by 70 % and also *inhibited* the activation of by 30 % . Negative_regulation EPHB2 AKT1 12514175 1063811 Together , our data suggest that GDF-15 prevents apoptosis in CGN by activating and *inhibiting* endogenously active [ERK] . Negative_regulation EPHB2 AKT1 14978732 1213593 ( 2 ) the use of E-cadherin blocking antibodies efficiently prevents phosphorylation and [MEK-ERK] *inhibition* after 70 min of calcium restoration ; Negative_regulation EPHB2 AKT1 15263001 1296092 Inhibition of or phosphatidylinositol 3-kinase also *allowed* cAMP dependent activation of B-Raf and [ERK] in normal calcium . Negative_regulation EPHB2 AKT1 15337530 1291363 We have characterized the *role* of Drosophila PI3K and in [ERK] pathway activation involving insulin induced proliferation using Drosophila Schneider cells . Negative_regulation EPHB2 AKT1 15791648 1397423 The inhibition of phosphatidylinositol 3-kinase <(PI3K)/Akt> signaling by LY294002 *increased* the [Erk] activation induced by the mutant B-raf proteins , as well as by wild-type B-raf . Negative_regulation EPHB2 AKT1 16238696 1489469 Elevated activity in turn suppressed Raf activity and *induced* a decline in [ERK] activation . Negative_regulation EPHB2 AKT1 17418380 1748752 In contrast , phosphoinositide-3 inhibition *increased* phosphorylation of [ERK] and Smads , leading to increased TIMP-1 . Negative_regulation EPHB2 AKT1 18538131 1928835 OML induced [ERK] phosphorylation was inhibited by specific inhibitors of PI3K and SFKs , and OML induced phosphorylation was *inhibited* by a inhibitor of SFKs . Negative_regulation EPHB2 AKT1 19201774 2149165 All COX inhibitors attenuated [ERK] activation , but only celecoxib significantly *inhibited* activation in HSCs . Negative_regulation EPHB2 AKT1 19762915 2158776 In normal human chondrocytes , tBHP triggered strong IRS-1 ( Ser-312 and Ser-616 ) and [ERK] phosphorylation and *inhibited* IGF-I induced IRS-1 ( Tyr-612 ) and phosphorylation . Negative_regulation EPHB2 AKT1 20512842 2270604 We found that low concentrations rapamycin increased Akt and [ERK] phosphorylation through a mTORC1 dependent mechanism because knockdowned raptor induced the activation of Akt and ERK , but higher doses of rapamycin *inhibited* and ERK phosphorylation mainly via the mTORC2 signaling pathway because that the silencing of rictor led to the inhibition of Akt and ERK phosphorylation . Negative_regulation EPHB2 AKT1 20668435 2317097 In addition , DHA caused AKT and [ERK] activation in a time dependent manner , and the DHA induced HO-1 upregulation could be *attenuated* by PI-3 and MEK/ERK inhibitors . Negative_regulation EPHB2 AKT1 20714148 2312966 Sorafenib reduced c-Kit , [ERK] and VEGFR2 activation and on the other hand , gemcitabine *inhibited* phosphorylation . Negative_regulation EPHB2 AKT1 21529991 2489594 Sorafenib reduced c-Kit and [ERK] activation and gemcitabine *inhibited* phosphorylation . Negative_regulation EPHB2 AKT1 21903772 2511205 inhibition in APC ( - ) /Pten ( - ) tumor cells *resulted* in compensatory upregulation of [ERK] signaling . Negative_regulation EPHB2 AKT1 21945981 2507229 Exposure of SW480 cells to ECG led to apoptosis as determined by caspase-3 activity , imbalance among Bcl-2 anti- and pro-apoptotic protein levels , [ERK] activation and *inhibition* , whereas PB2 treatment enhanced phospho-AKT and phospho-ERK levels . Negative_regulation EPHB2 AKT1 22129743 2515071 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 mitogen activated protein kinase (MAPK) and phosphorylation , but in contrast , *inhibited* that of [ERK] ( 1/2 ) . Negative_regulation EPHB2 AKT1 22509025 2589533 By suppressing GRK expression with siRNA , we demonstrated that lowering GRK5/6 abolishes IGF1 mediated ERK and AKT activation , whereas GRK2 inhibition increases [ERK] activation and partially *inhibits* signaling . Negative_regulation EPHB2 AKT1 23133361 2696558 The model confirms that phagocytosis associated changes in the composition of the cell membrane can inhibit ERK activity and predicts that and Ras-GAP synergize to *inhibit* [ERK] . Negative_regulation EPHB2 AKT1 23817184 2815706 [ERK] was activated under the basal conditions in MSTO-211H cells , and the activation was *prevented* by inhibitors for PI3 kinase , PDK1 , Akt , and Rac1 or by knocking-down PI3 kinase , PDK1 , , and Rac1 . Negative_regulation EPHB2 AKT2 10629859 576446 Expression of GRK2-ct inhibited the H2O2 induced activation of [ERK] by 70 % and also *inhibited* the activation of by 30 % . Negative_regulation EPHB2 AKT2 12514175 1063812 Together , our data suggest that GDF-15 prevents apoptosis in CGN by activating and *inhibiting* endogenously active [ERK] . Negative_regulation EPHB2 AKT2 14978732 1213594 ( 2 ) the use of E-cadherin blocking antibodies efficiently prevents phosphorylation and [MEK-ERK] *inhibition* after 70 min of calcium restoration ; Negative_regulation EPHB2 AKT2 15263001 1296093 Inhibition of or phosphatidylinositol 3-kinase also *allowed* cAMP dependent activation of B-Raf and [ERK] in normal calcium . Negative_regulation EPHB2 AKT2 15337530 1291364 We have characterized the *role* of Drosophila PI3K and in [ERK] pathway activation involving insulin induced proliferation using Drosophila Schneider cells . Negative_regulation EPHB2 AKT2 15791648 1397424 The inhibition of phosphatidylinositol 3-kinase <(PI3K)/Akt> signaling by LY294002 *increased* the [Erk] activation induced by the mutant B-raf proteins , as well as by wild-type B-raf . Negative_regulation EPHB2 AKT2 16238696 1489470 Elevated activity in turn suppressed Raf activity and *induced* a decline in [ERK] activation . Negative_regulation EPHB2 AKT2 17418380 1748753 In contrast , phosphoinositide-3 inhibition *increased* phosphorylation of [ERK] and Smads , leading to increased TIMP-1 . Negative_regulation EPHB2 AKT2 18538131 1928836 OML induced [ERK] phosphorylation was inhibited by specific inhibitors of PI3K and SFKs , and OML induced phosphorylation was *inhibited* by a inhibitor of SFKs . Negative_regulation EPHB2 AKT2 19201774 2149166 All COX inhibitors attenuated [ERK] activation , but only celecoxib significantly *inhibited* activation in HSCs . Negative_regulation EPHB2 AKT2 19762915 2158777 In normal human chondrocytes , tBHP triggered strong IRS-1 ( Ser-312 and Ser-616 ) and [ERK] phosphorylation and *inhibited* IGF-I induced IRS-1 ( Tyr-612 ) and phosphorylation . Negative_regulation EPHB2 AKT2 20512842 2270605 We found that low concentrations rapamycin increased Akt and [ERK] phosphorylation through a mTORC1 dependent mechanism because knockdowned raptor induced the activation of Akt and ERK , but higher doses of rapamycin *inhibited* and ERK phosphorylation mainly via the mTORC2 signaling pathway because that the silencing of rictor led to the inhibition of Akt and ERK phosphorylation . Negative_regulation EPHB2 AKT2 20668435 2317098 In addition , DHA caused AKT and [ERK] activation in a time dependent manner , and the DHA induced HO-1 upregulation could be *attenuated* by PI-3 and MEK/ERK inhibitors . Negative_regulation EPHB2 AKT2 20714148 2312967 Sorafenib reduced c-Kit , [ERK] and VEGFR2 activation and on the other hand , gemcitabine *inhibited* phosphorylation . Negative_regulation EPHB2 AKT2 21529991 2489595 Sorafenib reduced c-Kit and [ERK] activation and gemcitabine *inhibited* phosphorylation . Negative_regulation EPHB2 AKT2 21903772 2511206 inhibition in APC ( - ) /Pten ( - ) tumor cells *resulted* in compensatory upregulation of [ERK] signaling . Negative_regulation EPHB2 AKT2 21945981 2507230 Exposure of SW480 cells to ECG led to apoptosis as determined by caspase-3 activity , imbalance among Bcl-2 anti- and pro-apoptotic protein levels , [ERK] activation and *inhibition* , whereas PB2 treatment enhanced phospho-AKT and phospho-ERK levels . Negative_regulation EPHB2 AKT2 22129743 2515072 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 mitogen activated protein kinase (MAPK) and phosphorylation , but in contrast , *inhibited* that of [ERK] ( 1/2 ) . Negative_regulation EPHB2 AKT2 22509025 2589534 By suppressing GRK expression with siRNA , we demonstrated that lowering GRK5/6 abolishes IGF1 mediated ERK and AKT activation , whereas GRK2 inhibition increases [ERK] activation and partially *inhibits* signaling . Negative_regulation EPHB2 AKT2 23133361 2696559 The model confirms that phagocytosis associated changes in the composition of the cell membrane can inhibit ERK activity and predicts that and Ras-GAP synergize to *inhibit* [ERK] . Negative_regulation EPHB2 AKT2 23817184 2815707 [ERK] was activated under the basal conditions in MSTO-211H cells , and the activation was *prevented* by inhibitors for PI3 kinase , PDK1 , Akt , and Rac1 or by knocking-down PI3 kinase , PDK1 , , and Rac1 . Negative_regulation EPHB2 AKT3 10629859 576447 Expression of GRK2-ct inhibited the H2O2 induced activation of [ERK] by 70 % and also *inhibited* the activation of by 30 % . Negative_regulation EPHB2 AKT3 12514175 1063813 Together , our data suggest that GDF-15 prevents apoptosis in CGN by activating and *inhibiting* endogenously active [ERK] . Negative_regulation EPHB2 AKT3 14978732 1213595 ( 2 ) the use of E-cadherin blocking antibodies efficiently prevents phosphorylation and [MEK-ERK] *inhibition* after 70 min of calcium restoration ; Negative_regulation EPHB2 AKT3 15263001 1296094 Inhibition of or phosphatidylinositol 3-kinase also *allowed* cAMP dependent activation of B-Raf and [ERK] in normal calcium . Negative_regulation EPHB2 AKT3 15337530 1291365 We have characterized the *role* of Drosophila PI3K and in [ERK] pathway activation involving insulin induced proliferation using Drosophila Schneider cells . Negative_regulation EPHB2 AKT3 15791648 1397425 The inhibition of phosphatidylinositol 3-kinase <(PI3K)/Akt> signaling by LY294002 *increased* the [Erk] activation induced by the mutant B-raf proteins , as well as by wild-type B-raf . Negative_regulation EPHB2 AKT3 16238696 1489471 Elevated activity in turn suppressed Raf activity and *induced* a decline in [ERK] activation . Negative_regulation EPHB2 AKT3 17418380 1748754 In contrast , phosphoinositide-3 inhibition *increased* phosphorylation of [ERK] and Smads , leading to increased TIMP-1 . Negative_regulation EPHB2 AKT3 18538131 1928837 OML induced [ERK] phosphorylation was inhibited by specific inhibitors of PI3K and SFKs , and OML induced phosphorylation was *inhibited* by a inhibitor of SFKs . Negative_regulation EPHB2 AKT3 19201774 2149167 All COX inhibitors attenuated [ERK] activation , but only celecoxib significantly *inhibited* activation in HSCs . Negative_regulation EPHB2 AKT3 19762915 2158778 In normal human chondrocytes , tBHP triggered strong IRS-1 ( Ser-312 and Ser-616 ) and [ERK] phosphorylation and *inhibited* IGF-I induced IRS-1 ( Tyr-612 ) and phosphorylation . Negative_regulation EPHB2 AKT3 20512842 2270606 We found that low concentrations rapamycin increased Akt and [ERK] phosphorylation through a mTORC1 dependent mechanism because knockdowned raptor induced the activation of Akt and ERK , but higher doses of rapamycin *inhibited* and ERK phosphorylation mainly via the mTORC2 signaling pathway because that the silencing of rictor led to the inhibition of Akt and ERK phosphorylation . Negative_regulation EPHB2 AKT3 20668435 2317099 In addition , DHA caused AKT and [ERK] activation in a time dependent manner , and the DHA induced HO-1 upregulation could be *attenuated* by PI-3 and MEK/ERK inhibitors . Negative_regulation EPHB2 AKT3 20714148 2312968 Sorafenib reduced c-Kit , [ERK] and VEGFR2 activation and on the other hand , gemcitabine *inhibited* phosphorylation . Negative_regulation EPHB2 AKT3 21529991 2489596 Sorafenib reduced c-Kit and [ERK] activation and gemcitabine *inhibited* phosphorylation . Negative_regulation EPHB2 AKT3 21903772 2511207 inhibition in APC ( - ) /Pten ( - ) tumor cells *resulted* in compensatory upregulation of [ERK] signaling . Negative_regulation EPHB2 AKT3 21945981 2507231 Exposure of SW480 cells to ECG led to apoptosis as determined by caspase-3 activity , imbalance among Bcl-2 anti- and pro-apoptotic protein levels , [ERK] activation and *inhibition* , whereas PB2 treatment enhanced phospho-AKT and phospho-ERK levels . Negative_regulation EPHB2 AKT3 22129743 2515073 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 mitogen activated protein kinase (MAPK) and phosphorylation , but in contrast , *inhibited* that of [ERK] ( 1/2 ) . Negative_regulation EPHB2 AKT3 22509025 2589535 By suppressing GRK expression with siRNA , we demonstrated that lowering GRK5/6 abolishes IGF1 mediated ERK and AKT activation , whereas GRK2 inhibition increases [ERK] activation and partially *inhibits* signaling . Negative_regulation EPHB2 AKT3 23133361 2696560 The model confirms that phagocytosis associated changes in the composition of the cell membrane can inhibit ERK activity and predicts that and Ras-GAP synergize to *inhibit* [ERK] . Negative_regulation EPHB2 AKT3 23817184 2815708 [ERK] was activated under the basal conditions in MSTO-211H cells , and the activation was *prevented* by inhibitors for PI3 kinase , PDK1 , Akt , and Rac1 or by knocking-down PI3 kinase , PDK1 , , and Rac1 . Negative_regulation EPHB2 AKTIP 16154539 1461333 *suppressed* cisplatin induced renal dysfunction and [ERK] activation in the kidney . Negative_regulation EPHB2 AKTIP 16325498 1488131 Significant phosphorylation of [ERK] was measured following exposure of the cells to LPS and thrombin and this was *blocked* by the Ras inhibitor . Negative_regulation EPHB2 ANGPT2 10406835 629630 In this study , we examined the role of extracellular signal regulated kinase ( ERK ) in Ang II-mediated TGF-beta(1) expression in VSMCs and the *role* of in aortic [ERK] activity of stroke-prone spontaneously hypertensive rats . Negative_regulation EPHB2 ANGPT2 11322781 807188 Antioxidants such as catalase or N-acetyl-cysteine decreased Ang II-activated [ERK] phosphorylation and *inhibited* beta-MyHC promoter activity . Negative_regulation EPHB2 ANGPT2 16522324 1567939 The transactivation of EGF receptor *resulted* in activation of extracellular signal regulated kinase ( [ERK] ) that was also inhibited by valsartan , and enhanced by PD123319 . Negative_regulation EPHB2 ANGPT2 24447911 2923052 Moreover , *suppressed* the pro-apoptotic PTEN , and the [ERK] negative regulator Sprouty homologue 1 (SPRY1) , but induced the metalloendopeptidase MMP2 , all in a manner that was miR-21 dependent . Negative_regulation EPHB2 ANPEP 21666115 2470857 Thus inhibits ROS induced cardiomyocyte remodeling by activating AMPK and *inhibiting* [ERK] signaling and NF-?B activity . Negative_regulation EPHB2 ANXA1 19553536 2104080 GC-induced GILZ expression and GC inhibition of NF-kappaB activation were restored by expression of in ANXA1 ( -/- ) cells , and GILZ overexpression in ANXA1 ( -/- ) macrophages *reduced* [ERK] MAPK phosphorylation and restored sensitivity of cytokine expression and NF-kappaB activation to GC . Negative_regulation EPHB2 ANXA1 23267026 2732561 Similarly , experiments using AnxA1 ( -/- ) OT-II CD4 ( + ) T cells demonstrated that the absence of in T cells was sufficient to induce increased Ag-specific CD4 ( + ) T cell proliferation in vivo , augment T cell production of IFN-? , IL-17 , TNF , and IL-6 , and *increase* Akt , [ERK] , and p38 activation . Negative_regulation EPHB2 ANXA5 10871841 708220 This work shows that overexpression *suppresses* the TPA induced [Ras/ERK] signaling by inhibiting at/or upstream of Shc , possibly through the inhibition of PKCs . Negative_regulation EPHB2 ANXA5 18057187 1861406 Furthermore , a neutralizing TGF-beta1 antibody or exogenous to bind PS *prevented* sevoflurane induced [ERK] and Akt phosphorylation and HSP70 induction in HK-2 cells . Negative_regulation EPHB2 ANXA6 15940262 1445895 Expression of annexin A6 in A431 cells reduced , while RNAi mediated suppression of in HeLa cells *enhanced* EGF induced Ras and [Erk] activation . Negative_regulation EPHB2 ANXA6 22715163 2634058 Lovastatin alone significantly reduced MPC and MTT cell viability at therapeutically relevant doses and *inhibited* both [ERK] and AKT signalling , but increased signalling . Negative_regulation EPHB2 APC 12937827 1133036 *inhibited* the over activation of both [ERK] ( 1/2 ) and p38 during the following sustained anoxia . Negative_regulation EPHB2 APC 16478791 1528367 *inhibits* [ERK] pathway activation and cellular proliferation induced by RAS . Negative_regulation EPHB2 APC 16478791 1528371 ERK activity was increased by Cre-virus induced Apc knockout in primary Apc ( flox/flox ) mouse embryonic fibroblasts , indicating that *inhibits* [ERK] activity . Negative_regulation EPHB2 APOA2 21300819 2398489 *inhibited* the Con A-induced activation of [ERK-MAPK] and nuclear translocation of NFAT in CD4 T cells . Negative_regulation EPHB2 APOB 11509543 848327 Pretreatment of VSMC with a cell-permeable MEK inhibitor ( PD-98059 , 40 micromol/l ) significantly decreased [ERK] phosphorylation in *response* to native and modified . Negative_regulation EPHB2 APOB 15750341 1379865 In addition , pretreatment of the RASMCs with a cell-permeable mitogen activated protein kinase kinase ( MEK ) inhibitor ( PD98059 , 5 microM ) markedly decreased [ERK] phosphorylation in *response* to native and glycated . Negative_regulation EPHB2 APOB 16246039 1471352 Oxidized low-density *inhibits* insulin dependent phosphorylation of the signalling kinases [ERK] ( extracellular-signal regulated kinase ) and PKB/Akt . Negative_regulation EPHB2 AQP5 24747567 2939315 Conversely , in NIH-3T3 cells , overexpression of *increased* KC expression , NF-?B activation , and [ERK] phosphorylation . Negative_regulation EPHB2 AREG 16737974 1585290 [ERK] phosphorylation was *attenuated* by 1 ) neutralizing EGFR antibodies and the EGFR kinase inhibitor , AG1478 , 2 ) neutralizing HB-EGF , but not , antibodies , heparin , or CM197 , and 3 ) pharmacological inhibitors of matrix degrading metalloproteinases or TACE small interfering RNA . Negative_regulation EPHB2 ARF1 15273738 1296409 is *required* for suppression of EGFR/DeltaEGFR ( 2-7 ) -dependent [ERK] activation in mouse astrocytes and glioma . Negative_regulation EPHB2 ARF3 15273738 1296410 is *required* for suppression of EGFR/DeltaEGFR ( 2-7 ) -dependent [ERK] activation in mouse astrocytes and glioma . Negative_regulation EPHB2 ARF4 15273738 1296411 is *required* for suppression of EGFR/DeltaEGFR ( 2-7 ) -dependent [ERK] activation in mouse astrocytes and glioma . Negative_regulation EPHB2 ARF5 15273738 1296412 is *required* for suppression of EGFR/DeltaEGFR ( 2-7 ) -dependent [ERK] activation in mouse astrocytes and glioma . Negative_regulation EPHB2 ARF6 15273738 1296413 is *required* for suppression of EGFR/DeltaEGFR ( 2-7 ) -dependent [ERK] activation in mouse astrocytes and glioma . Negative_regulation EPHB2 ARF6 16413265 1494796 To investigate the *role* of in tumor cell invasion and [ERK] activation , a number of methods were employed . Negative_regulation EPHB2 ARF6 16452216 1522115 We further showed that ARF6/extracellular signal regulated kinase ( ERK ) signaling is required for the EFA6A mediated cell invasion because both EFA6A ( E242K ) and ARF6 dominant negative mutant ( T27N ) markedly *reduced* the phosphorylated [ERK] level and EFA6A mediated invasive capacity . Negative_regulation EPHB2 ARF6 22701712 2615853 Ectopic expression GEP100 siRNA , GEP100-?PH , or *suppressed* EGF induced [ERK] and Rac1 activity . Negative_regulation EPHB2 ARG1 15680253 1369888 Interestingly , the integrin antagonist also *caused* the disruption of R-methanandamide mediated [ERK] and FAK responses and upset the integrity of excitatory synapses . Negative_regulation EPHB2 ARG2 15680253 1369889 Interestingly , the integrin antagonist also *caused* the disruption of R-methanandamide mediated [ERK] and FAK responses and upset the integrity of excitatory synapses . Negative_regulation EPHB2 ARID1A 20371669 2273393 Furthermore , treatment with 3MA markedly down-regulated capsaicin induced p38 activation and LC3 conversion , and completely *down-regulated* [ERK] activation and led to LC3II accumulation . Negative_regulation EPHB2 ARRB2 17540773 1767324 Reciprocally , small interfering RNA mediated silencing of endogenous expression *restored* TGF-beta mediated [ERK] activation and increased endothelial cell migration in an endoglin dependent manner . Negative_regulation EPHB2 ARRB2 23750009 2828132 *inhibited* MC1R agonist dependent cAMP production but not [ERK] activation , stimulated internalization and showed prolonged co-localization with the receptor in endocytic vesicles . Negative_regulation EPHB2 ASIP 15680253 1369890 Interestingly , the integrin antagonist also *caused* the disruption of R-methanandamide mediated [ERK] and FAK responses and upset the integrity of excitatory synapses . Negative_regulation EPHB2 ATP5O 10712238 673938 These findings suggest that Na ( + ) -K ( + ) <-ATPase> inhibition by bufalin *induces* calcium influx and thereby activates PKC and [ERK] . Negative_regulation EPHB2 ATP6AP2 18250563 1839650 A human ( pro ) was present in hVSMCs , and its knockdown with small interfering RNA ( siRNA ) significantly *inhibited* the prorenin induced [ERK] activation . Negative_regulation EPHB2 AXIN1 17374607 1734750 *inhibits* cellular proliferation and [ERK] pathway activation induced by either epidermal growth factor or Ras , indicating a role of Axin in the regulation of growth induced by ERK pathway activation . Negative_regulation EPHB2 AXIN2 17374607 1734751 *inhibits* cellular proliferation and [ERK] pathway activation induced by either epidermal growth factor or Ras , indicating a role of Axin in the regulation of growth induced by ERK pathway activation . Negative_regulation EPHB2 BAI1 23782696 2824144 This constitutive activity of the truncated mutant also *resulted* in enhanced downstream phosphorylation of [ERK] as well as increased receptor association with ß-arrestin2 and increased ubiquitination of the receptor . Negative_regulation EPHB2 BCL10 12926052 1131569 evidence for a *dependent* pathway and impairment in [ERK] activity . Negative_regulation EPHB2 BCL10 16621790 1569276 We found that directly bound to ERKs and *inhibited* [ERK] activation by MEK1 . Negative_regulation EPHB2 BCL2 12926052 1131570 evidence for a *dependent* pathway and impairment in [ERK] activity . Negative_regulation EPHB2 BCL2 16621790 1569277 We found that directly bound to ERKs and *inhibited* [ERK] activation by MEK1 . Negative_regulation EPHB2 BCL2 16630579 1562886 Cyclosporin-A *inhibits* [ERK] phosphorylation in B cells by modulating the binding of Raf protein to . Negative_regulation EPHB2 BCL2 23741975 2909180 Combined treatment with rapamycin and IDA down-regulated and Mcl-1 , and *inhibited* the activation of phosphoinositide 3-kinase (PI3K)/mTOR and extracellular signal related kinase ( [ERK] ) . Negative_regulation EPHB2 BCL3 12926052 1131571 evidence for a *dependent* pathway and impairment in [ERK] activity . Negative_regulation EPHB2 BCL3 16621790 1569278 We found that directly bound to ERKs and *inhibited* [ERK] activation by MEK1 . Negative_regulation EPHB2 BCL5 12926052 1131566 evidence for a *dependent* pathway and impairment in [ERK] activity . Negative_regulation EPHB2 BCL5 16621790 1569273 We found that directly bound to ERKs and *inhibited* [ERK] activation by MEK1 . Negative_regulation EPHB2 BCL6 12926052 1131567 evidence for a *dependent* pathway and impairment in [ERK] activity . Negative_regulation EPHB2 BCL6 16621790 1569274 We found that directly bound to ERKs and *inhibited* [ERK] activation by MEK1 . Negative_regulation EPHB2 BCL9 12926052 1131568 evidence for a *dependent* pathway and impairment in [ERK] activity . Negative_regulation EPHB2 BCL9 16621790 1569275 We found that directly bound to ERKs and *inhibited* [ERK] activation by MEK1 . Negative_regulation EPHB2 BCR 12095152 960707 In contrast , cross linking *resulted* in [ERK] activation , although the activation in quiescent cells was case dependent . Negative_regulation EPHB2 BCR 18048365 1861116 activation results in the induction of c-Fos , FosB , and JunB , and expression of these are *suppressed* by [ERK] and JNK inhibitors . Negative_regulation EPHB2 BDNF 17532077 1778378 Brain derived neurotrophic factor (BDNF) activated [ERK] in the dorsal horn , and *blocked* the DRG induced ERK activation . Negative_regulation EPHB2 BDNF 17532077 1778382 These results suggest *roles* of in the DRG induced [ERK] activation in the embryonic dorsal horn . Negative_regulation EPHB2 BDNF 17908330 1824272 Agmatine reduced phosphorylation of JNK and NF-kappaB , while *suppressed* phosphorylation of [ERK] and p38 . Negative_regulation EPHB2 BDNF 19732758 2202759 Within 22 hours after infusion into the prefrontal cortex , increases BDNF protein in prefrontal cortical targets , including nucleus accumbens , and *restores* cocaine mediated decreases in [phospho-ERK] expression in the nucleus accumbens . Negative_regulation EPHB2 BDNF 22700586 2633796 Two factors that promote chondrocyte differentiation , and C-type natriuretic peptide , increase p38 activity while decreasing , but not completely *inhibiting* , [ERK] activity . Negative_regulation EPHB2 BMP1 22528752 2618575 We recently found that while LIF signaling augments ERK activity , signaling *inhibits* [ERK] activity in mouse ES cells via direct upregulation of an ERK phosphatase-dual-specificity phosphatase 9 . Negative_regulation EPHB2 BMP10 22528752 2618583 We recently found that while LIF signaling augments ERK activity , signaling *inhibits* [ERK] activity in mouse ES cells via direct upregulation of an ERK phosphatase-dual-specificity phosphatase 9 . Negative_regulation EPHB2 BMP15 22528752 2618576 We recently found that while LIF signaling augments ERK activity , signaling *inhibits* [ERK] activity in mouse ES cells via direct upregulation of an ERK phosphatase-dual-specificity phosphatase 9 . Negative_regulation EPHB2 BMP2 22528752 2618577 We recently found that while LIF signaling augments ERK activity , signaling *inhibits* [ERK] activity in mouse ES cells via direct upregulation of an ERK phosphatase-dual-specificity phosphatase 9 . Negative_regulation EPHB2 BMP3 22528752 2618578 We recently found that while LIF signaling augments ERK activity , signaling *inhibits* [ERK] activity in mouse ES cells via direct upregulation of an ERK phosphatase-dual-specificity phosphatase 9 . Negative_regulation EPHB2 BMP4 20504958 2270456 Mechanistic studies show that *inhibits* [FGF/ERK] activity at the first stage but not at the second stage ; Negative_regulation EPHB2 BMP4 21742013 2471828 Stimulation with CRH , but not GHRP-2 , activated ERK1/2 , p38 , SAPK/JNK and Akt phosphorylation , in which CRH induced phosphorylation of [ERK] and p38 was *suppressed* by . Negative_regulation EPHB2 BMP4 22305567 2552205 Here , we show that , whereas LIF sustains relatively high ERK activity , can steadily *attenuate* [ERK] activity by upregulating ERK-specific dual-specificity phosphatase 9 (DUSP9) . Negative_regulation EPHB2 BMP4 22528752 2618579 We recently found that while LIF signaling augments ERK activity , signaling *inhibits* [ERK] activity in mouse ES cells via direct upregulation of an ERK phosphatase-dual-specificity phosphatase 9 . Negative_regulation EPHB2 BMP5 22528752 2618580 We recently found that while LIF signaling augments ERK activity , signaling *inhibits* [ERK] activity in mouse ES cells via direct upregulation of an ERK phosphatase-dual-specificity phosphatase 9 . Negative_regulation EPHB2 BMP6 22528752 2618581 We recently found that while LIF signaling augments ERK activity , signaling *inhibits* [ERK] activity in mouse ES cells via direct upregulation of an ERK phosphatase-dual-specificity phosphatase 9 . Negative_regulation EPHB2 BMP7 22528752 2618582 We recently found that while LIF signaling augments ERK activity , signaling *inhibits* [ERK] activity in mouse ES cells via direct upregulation of an ERK phosphatase-dual-specificity phosphatase 9 . Negative_regulation EPHB2 BRAF 15278365 1277267 Transfection of 95 kDa into confluent NHK *resulted* in a cAMP dependent increase in [ERK] phosphorylation and cell proliferation . Negative_regulation EPHB2 BRAF 16432225 1521553 Essential *role* of in [ERK] activation during extraembryonic development . Negative_regulation EPHB2 BRAF 17050671 1636149 No simple correlation of endogenous BRAF mutational status and antigen levels was observed , but transient overexpression of V600E *increased* [ERK] activation and reduced Melan-A/MART-1 levels in antigen positive cell lines . Negative_regulation EPHB2 BRAF 20810616 2341716 We found that nanomolar concentrations of Sorafenib reduced the basal activity of [ERK] , *inhibited* cAMP dependent activation of and MEK/ERK signaling , and caused a concentration dependent inhibition of cell proliferation induced by cAMP , epidermal growth factor , or the combination of the two agonists . Negative_regulation EPHB2 BRCA1 15199145 1260674 The proliferation of MCF-7 cells induced by E2 was significantly inhibited by PD98059 , a specific [ERK] *inhibitor* , or by dominant negative ERK2 expression and by expression of wt ( but not mutant BRCA1 ) . Negative_regulation EPHB2 BRCC3 17143545 1668118 These findings demonstrate that BRCC3 is a novel effector of Raf-1 , and implicate a *role* of in modulation of [p-ERK] , cell survival and proliferation . Negative_regulation EPHB2 BSG 22870202 2641290 and KD of CD44 or *down-regulated* p-Akt and [p-Erk] , the main signal modulators associated with cell growth and survival . Negative_regulation EPHB2 BUD13 17919386 1804149 U0126 and *inhibited* the phosphorylation of [ERK] in the cells stimulated by PDGF-BB of the concentration of 25 microg/L. there was no difference in the level of TGF-beta1 in the cell culture supernatant among different groups . Negative_regulation EPHB2 BUD31 17919386 1804150 U0126 and *inhibited* the phosphorylation of [ERK] in the cells stimulated by PDGF-BB of the concentration of 25 microg/L. there was no difference in the level of TGF-beta1 in the cell culture supernatant among different groups . Negative_regulation EPHB2 CA1 22777671 2676515 Furthermore , we show that activity induced phosphorylation of [ERK] and CREB is *impaired* in the hippocampal of Zbtb20 mutant mice . Negative_regulation EPHB2 CA2 15336602 1291253 Using Western analysis , we observed that an increase in extracellular *resulted* in delayed activation of extracellular signal regulated kinase ( [ERK] ) in PC-3 cells . Negative_regulation EPHB2 CA2 15389575 1354283 Conversely , using reporter gene assays and Western blot analysis , we have demonstrated that high extracellular desensitizes the RANKL induced activation of NF-kappaB and c-Jun N-terminal kinase (JNK) , and *inhibits* constitutive and RANKL stimulated [ERK] phosphorylation , indicating a negative feed-back mechanism via specific RANKL signaling pathways . Negative_regulation EPHB2 CA2 15606897 1356915 In contrast , 5-HT7A receptor mediated activation of Akt required increases in both [ cAMP ] and intracellular [ Ca2+ ] , while activation of [ERK] was *inhibited* by . Negative_regulation EPHB2 CA2 16319189 1503082 Elevation of intracellular levels in ADPKD cells increased Akt activity and *blocked* cAMP dependent B-Raf and [ERK] activation . Negative_regulation EPHB2 CA2 23433299 2827503 ROS and influx inhibition , in turn , *increased* [ERK] phosphorylation , and hence almost entirely suppressed GSE mediated apoptosis . Negative_regulation EPHB2 CALCA 22335784 2586614 In cultured A172 cells , functional studies demonstrated stimulation of adenylyl cyclase and *inhibition* of [extracellular regulated kinase (ERK)1/2] phosphorylation . Negative_regulation EPHB2 CAMP 19307752 2087012 *caused* a dramatic inhibition of [ERK] and p38 MAPK activity , which is induced by SAA . Negative_regulation EPHB2 CASP1 22334892 2554003 In response to mutant Htt , [ERK] is activated and directs a protective transcriptional response and *inhibits* activation . Negative_regulation EPHB2 CASP10 22334892 2554004 In response to mutant Htt , [ERK] is activated and directs a protective transcriptional response and *inhibits* activation . Negative_regulation EPHB2 CASP12 22334892 2554014 In response to mutant Htt , [ERK] is activated and directs a protective transcriptional response and *inhibits* activation . Negative_regulation EPHB2 CASP14 22334892 2554005 In response to mutant Htt , [ERK] is activated and directs a protective transcriptional response and *inhibits* activation . Negative_regulation EPHB2 CASP16 22334892 2554015 In response to mutant Htt , [ERK] is activated and directs a protective transcriptional response and *inhibits* activation . Negative_regulation EPHB2 CASP2 22334892 2554006 In response to mutant Htt , [ERK] is activated and directs a protective transcriptional response and *inhibits* activation . Negative_regulation EPHB2 CASP3 12048219 968721 Ectopic expression of PKCalpha or -zeta did not affect p38 kinase or [ERK] but *inhibited* the p53 accumulation and activation that are required for NO-induced apoptosis of chondrocytes . Negative_regulation EPHB2 CASP3 20347949 2281899 In addition , MWG extract attenuated activation of and poly ADP-ribose polymerase (PARP) and *inhibited* the phosphorylation of [ERK] , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation EPHB2 CASP3 22334892 2554007 In response to mutant Htt , [ERK] is activated and directs a protective transcriptional response and *inhibits* activation . Negative_regulation EPHB2 CASP3 24084189 2882565 In the addition of PLX4032 to apigenin , compared with the treatment of apigenin alone , the protein levels of cleaved PARP-1 and cleaved were elevated , and [phospho-ERK] protein levels were *reduced* , and the protein levels of total ERK , c-Myc , BRAF , phospho-Akt , phospho-p70S6K and phospho-4EBP1 were not varied . Negative_regulation EPHB2 CASP4 22334892 2554008 In response to mutant Htt , [ERK] is activated and directs a protective transcriptional response and *inhibits* activation . Negative_regulation EPHB2 CASP5 22334892 2554009 In response to mutant Htt , [ERK] is activated and directs a protective transcriptional response and *inhibits* activation . Negative_regulation EPHB2 CASP6 22334892 2554010 In response to mutant Htt , [ERK] is activated and directs a protective transcriptional response and *inhibits* activation . Negative_regulation EPHB2 CASP7 22334892 2554011 In response to mutant Htt , [ERK] is activated and directs a protective transcriptional response and *inhibits* activation . Negative_regulation EPHB2 CASP8 12736263 1112946 Despite this , it completely suppresses PICD by sustaining [ERK] activation and *inhibiting* activation in phagocytosing neutrophils . Negative_regulation EPHB2 CASP8 16129431 1461138 This conclusion is based on the following observations : ( I ) Overexpression of FADD , , or a c-FLIP protein containing the death effector domains only *leads* to enhanced and prolonged [ERK] activation after TNF treatment . Negative_regulation EPHB2 CASP8 22334892 2554012 In response to mutant Htt , [ERK] is activated and directs a protective transcriptional response and *inhibits* activation . Negative_regulation EPHB2 CASP9 22334892 2554013 In response to mutant Htt , [ERK] is activated and directs a protective transcriptional response and *inhibits* activation . Negative_regulation EPHB2 CAST 18027879 1866886 A that partially rescued FAK degradation also *prevented* low rigidity induced [ERK] phosphorylation . Negative_regulation EPHB2 CAT 10471390 641779 Silica induced [ERK] phosphorylation was also effectively *attenuated* by and DPI . Negative_regulation EPHB2 CAT 10801894 708025 *blocked* [ERK] activation by H ( 2 ) O ( 2 ) , but not by ONOO ( - ) , demonstrating that the effect of ONOO ( - ) was not due to the generation of H ( 2 ) O ( 2 ) . Negative_regulation EPHB2 CAT 11603923 871271 This strain activated [ERK] phosphorylation was attenuated in the *presence* of . Negative_regulation EPHB2 CAT 12646200 1069938 , either membrane bound or intracellular , but not native catalase , *inhibited* serum induced Elk phosphorylation and anisomycin- and/or MG-132 induced [ERK] phosphorylation , suggesting the involvement of H ( 2 ) O ( 2 ) . Negative_regulation EPHB2 CAT 15895830 1407929 The [ERK] activation and cell death induced by H2O2 was *prevented* by , the hydrogen peroxide scavenger , and U0126 , an inhibitor of ERK upstream kinase MEK1/2 . Negative_regulation EPHB2 CAT 17922126 1903087 But [ERK] phosphorylation was not *inhibited* by and was abrogated completely by the thiol antioxidant . Negative_regulation EPHB2 CAT 19135025 2037661 Furthermore , significantly *attenuated* the intracellular peroxide production , phosphorylation of [ERK] and JNK , and all cytokine gene expressions induced by EGCG . Negative_regulation EPHB2 CAT 19467701 2102013 ( 500 and 1000 U/ml ) and U0126 ( 10 and 20 microm , a MEK inhibitor ) effectively *prevented* the BisGMA induced [ERK] activation , PGE ( 2 ) production and COX-2 expression . Negative_regulation EPHB2 CAT 20529870 2295446 [ERK] activation and MMP-9 expression were *recovered* by overexpressing or transfecting siRNA for the mitochondrial iron-sulfur protein , Rieske . Negative_regulation EPHB2 CAV1 15545301 1360770 We also demonstrate that down-regulation of endogenous expression *activates* [ERK] and that activation of the p42/44 MAP kinase pathway is necessary to promote muscle regeneration . Negative_regulation EPHB2 CAV1 15545301 1360771 Taken together , these results propose caveolin-1 as a novel regulator of satellite cell functions and suggest that the following signaling pathway modulates satellite cell activation during muscle repair : injured fibers release HGF -- > HGF down-regulates caveolin-1 protein expression -- > down-regulation of *activates* [ERK] -- > activation of ERK promotes muscle repair by stimulating the proliferation and migration of MPCs toward the wounded area . Negative_regulation EPHB2 CAV1 16115197 1448848 Forced expression of *suppressed* SCF- and IL-3 induced proliferation and [ERK] activation . Negative_regulation EPHB2 CAV1 16708022 1564242 *blocked* the formation of neurites and the phosphorylation of [Erk] upon bFGF treatment in N2a cells . Negative_regulation EPHB2 CAV1 19288272 2185409 The WT-MCF-7 cells showed abundant expression of caveolin-1 which potentiated oestrogen-receptor ( ERalpha ) signalling and promoted cell growth despite mediating *inhibition* of [ERK] signalling . Negative_regulation EPHB2 CAV1 19499152 2091877 These results revealed that the interaction between IFITM1 and could *enhance* the inhibitory effect of CAV-1 on [ERK] activation . Negative_regulation EPHB2 CAV3 16054119 1447828 ERK activation was decreased from 2 min to 5 min after KCl stimulation , which means that .1 activation *reduced* [ERK] activity in the very early stages of activation . Negative_regulation EPHB2 CBFA2T2 11350959 827792 The expression of a dominant negative mutant of or treatment with LY 294002 also *inhibited* UVB induced [Erk] phosphorylation . Negative_regulation EPHB2 CBL 11847211 929244 In contrast , the expression of drastically *reduced* the vc-Fms transformed phenotype and the activation of [Erk] and enhanced Fms ubiquitination via phosphotyrosine residue 977 . Negative_regulation EPHB2 CBL 15265912 1275620 The absence of *increased* the phosphorylation of [ERK] after receptor stimulation , but resulted in slightly reduced p38 phosphorylation and Ca ( 2+ ) response . Negative_regulation EPHB2 CBL 17056522 1636576 However , loss of does not *enhance* the activation of [ERK] or Akt , nor does it promote a greater calcium response . Negative_regulation EPHB2 CBL 19508871 2103047 Moreover , overexpression of significantly suppressed ERK activation , and Cbl-b ( DN ) strongly *enhanced* both [ERK] and Akt activation . Negative_regulation EPHB2 CBL 24466333 2907807 Cbl-c decreased downstream ERK activation by RETMEN2A and co-expression of Enigma blocked the *mediated* decrease in [ERK] activation . Negative_regulation EPHB2 CCDC134 18087676 1862351 , a novel secretory protein , *inhibits* activation of [ERK] and JNK , but not p38 MAPK . Negative_regulation EPHB2 CCL2 19224633 2044685 MCP-2/CCL8 ( 6-75 ) induced internalization of CCR2 , *inhibited* MCP-1/CCL2 and MCP-2/CCL8 [ERK] signaling and antagonized the chemotactic activity of several CCR2 ligands ( , MCP-2/CCL8 , MCP-3/CCL7 ) . Negative_regulation EPHB2 CCL3 14982949 1250924 Constitutively active mitogen activated protein kinase kinase ( MEK ) induced , and Ras dominant negative ( DN ) *inhibited* IC-induced [ERK] phosphorylation and MIP-1alpha production . Negative_regulation EPHB2 CCL8 19224633 2044686 ( 6-75 ) induced internalization of CCR2 , *inhibited* MCP-1/CCL2 and MCP-2/CCL8 [ERK] signaling and antagonized the chemotactic activity of several CCR2 ligands ( MCP-1/CCL2 , MCP-2/CCL8 , MCP-3/CCL7 ) . Negative_regulation EPHB2 CCND1 11123423 762770 EGF *induced* cell proliferation through [ERK] phosphorylation , since U0126 , which is an inhibitor of ERK phosphorylation , abrogated the increase of by EGF . Negative_regulation EPHB2 CCND1 11751523 889949 Treatment with EGCG inhibited phosphorylation of the EGFR , signal transducer and activator of transcription3 ( Stat3 ) , and [extracellular regulated kinase (ERK)] proteins and also *inhibited* basal and transforming growth factor-alpha stimulated c-fos and promoter activity . Negative_regulation EPHB2 CCR2 19224633 2044687 MCP-2/CCL8 ( 6-75 ) induced internalization of CCR2 , *inhibited* MCP-1/CCL2 and MCP-2/CCL8 [ERK] signaling and antagonized the chemotactic activity of several ligands ( MCP-1/CCL2 , MCP-2/CCL8 , MCP-3/CCL7 ) . Negative_regulation EPHB2 CD151 20581856 2285572 Overexpression of promoted cell proliferation , migration and tube formation in vitro , and phosphorylation of [ERK] was also *increased* . Negative_regulation EPHB2 CD209 16434485 1554427 ligation on dendritic cells *results* in [ERK] and PI3K activation and modulates cytokine production . Negative_regulation EPHB2 CD3D 14680820 1179138 Unexpectedly , dominant negative Ras17N blocked activation of Ras and [ERK] in *response* to IL-2R engagement but not ligation . Negative_regulation EPHB2 CD3E 14680820 1179139 Unexpectedly , dominant negative Ras17N blocked activation of Ras and [ERK] in *response* to IL-2R engagement but not ligation . Negative_regulation EPHB2 CD3G 14680820 1179140 Unexpectedly , dominant negative Ras17N blocked activation of Ras and [ERK] in *response* to IL-2R engagement but not ligation . Negative_regulation EPHB2 CD4 12594266 1060827 Stimulation of ( + ) T cells with a high affinity peptide *resulted* in sustained [Erk] activation and Th1 differentiation . Negative_regulation EPHB2 CD40 10586053 571648 We and others previously observed that IgM and stimulation in murine B cells *resulted* in activation of extracellular signal regulated kinase ( [ERK] ) , a subfamily of mitogen activated protein kinase . Negative_regulation EPHB2 CD40 8759724 377935 ligation *results* in protein kinase C-independent activation of [ERK] and JNK in resting murine splenic B cells . Negative_regulation EPHB2 CD40LG 15749869 1379674 We found that prior stimulation of primary murine B cells with markedly *enhanced* the level of [ERK] and JNK ( but not p38 MAPK ) phosphorylation produced by subsequently added anti-Ig Ab , and much , but not all , of this enhancement was independent of PI3K and phospholipase C . CD40L treatment similarly enhanced BCR induced MAPK kinase ( MEK ) phosphorylation , and MEK was required for enhancement of ERK . Negative_regulation EPHB2 CD79A 12095152 960708 In contrast , cross linking *resulted* in [ERK] activation , although the activation in quiescent cells was case dependent . Negative_regulation EPHB2 CD79B 12095152 960709 In contrast , cross linking *resulted* in [ERK] activation , although the activation in quiescent cells was case dependent . Negative_regulation EPHB2 CD81 14676841 1211197 In addition , overexpression of in HepG2 cells , NIH3T3 cells , and murine fibroblasts GD25 lacking the beta1 family of integrins *induces* cell proliferation and [ERK/MAPKinase] activation . Negative_regulation EPHB2 CD82 22266356 2559781 An examination of the effect of sialylation on epidermal growth factor receptor (EGFR) activity and downstream signaling , which are highly correlated with cell proliferation , showed that the loss of *augmented* EGF induced EGFR phosphorylation and activation of extracellular signal regulated kinase ( [ERK] ) in colon cancer cells . Negative_regulation EPHB2 CD8A 16872849 1600695 A delayed and perhaps longer lasting interaction *results* in delayed [phospho-ERK] recruitment to the synapse . Negative_regulation EPHB2 CD8B 16872849 1600696 A delayed and perhaps longer lasting interaction *results* in delayed [phospho-ERK] recruitment to the synapse . Negative_regulation EPHB2 CDC25A 15672448 1409535 Cdc25A and ERK interaction : EGFR independent [ERK] *activation* by a protein phosphatase inhibitor , compound 5 . Negative_regulation EPHB2 CDC37 18089825 1834932 We show that the loss of *leads* to reduced activity of the [Erk] , Akt , mTOR , and androgen induced pathways . Negative_regulation EPHB2 CDC42 12485852 1025102 Here , we describe that the inhibition of Rac1 or signaling *leads* to MAPK [ERK] activation via a pathway involving PI(3)K , Akt , Raf , and MEK , but not Ras . Negative_regulation EPHB2 CDH1 14978732 1213641 Our data suggest that engagement *leads* to [MEK/ERK] inhibition in a PI3K/Akt dependent pathway . Negative_regulation EPHB2 CDH1 21181094 2385810 uPA/ uPAR downregulation also induces expression and *inhibits* activation of [ERK] . Negative_regulation EPHB2 CDH1 24318272 2883344 Loss of *activates* [EGFR-MEK/ERK] signaling , which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer . Negative_regulation EPHB2 CDK1 15888452 1419477 We show that *inhibits* EGF mediated [ERK] activation through direct interaction and phosphorylation of several ERK pathway proteins , including the guanine nucleotide exchange factor , Sos-1 , and Raf-1 kinase . Negative_regulation EPHB2 CDK1 15888452 1419479 Inhibition of activity with roscovitine in mitotic cells *restored* [ERK] activation by EGF and PMA . Negative_regulation EPHB2 CDK5R1 22833568 2670900 The inhibition of activity *results* in enhanced [MEK-ERK] signaling , leading to CRNA . Negative_regulation EPHB2 CDKN1A 20664969 2298215 Immunoblot analysis demonstrated that oridonin treatment increased expression levels of p-JNK , p-p38 , p-p53 and , elevated the level of cyclin B1/p-Cdc2 ( Tyr15 ) complex , and *inhibited* the expression of [p-ERK] . Negative_regulation EPHB2 CDKN1A 23772367 2714472 VN attenuated radiation induced expression of , an inhibitor of cell cycle progression , and selectively *inhibited* [Erk-] and p38 MAPK dependent p21 induction after radiation exposure through regulation of the activity of GSK-3ß . Negative_regulation EPHB2 CDKN1B 15298730 1283532 PD98059 , a selective *inhibitor* of [ERK] phosphorylation , induced growth inhibition , the expression of and cell cycle arrest . Negative_regulation EPHB2 CDKN2A 15273738 1296408 is *required* for suppression of EGFR/DeltaEGFR ( 2-7 ) -dependent [ERK] activation in mouse astrocytes and glioma . Negative_regulation EPHB2 CEP104 10706714 673291 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP104 24045962 2902336 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP112 10706714 673303 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP112 24045962 2902348 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP120 10706714 673301 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP120 24045962 2902346 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP128 10706714 673289 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP128 24045962 2902334 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP135 10706714 673307 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP135 24045962 2902352 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP152 10706714 673309 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP152 24045962 2902354 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP164 10706714 673308 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP164 24045962 2902353 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP170 10706714 673304 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP170 24045962 2902349 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP19 10706714 673302 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP19 24045962 2902347 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP192 10706714 673294 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP192 24045962 2902339 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP250 10706714 673288 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP250 24045962 2902333 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP290 10706714 673305 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP290 24045962 2902350 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP350 10706714 673290 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP350 24045962 2902335 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP41 10706714 673287 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP41 24045962 2902332 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP44 10706714 673310 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP44 24045962 2902355 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP55 10706714 673286 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP55 24045962 2902331 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP57 10706714 673312 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP57 24045962 2902357 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP63 10706714 673298 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP63 24045962 2902343 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP68 10706714 673306 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP68 24045962 2902351 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP70 10706714 673311 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP70 24045962 2902356 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP72 10706714 673295 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP72 24045962 2902340 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP76 10706714 673296 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP76 24045962 2902341 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP78 10706714 673297 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP78 24045962 2902342 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP85 10706714 673293 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP85 24045962 2902338 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP89 10706714 673299 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP89 24045962 2902344 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP95 10706714 673292 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP95 24045962 2902337 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CEP97 10706714 673300 SB 203580 , PD 98059 , and attenuated IV-infection *induced* p38 MAP kinase activity , [Erk] activity , and JNK activity , respectively . Negative_regulation EPHB2 CEP97 24045962 2902345 Significantly , dose-dependently *suppressed* NF-?B activation , I?Ba degradation , and phosphorylation of [ERK] , JNK , and p38 induced by LPS . Negative_regulation EPHB2 CHKB 17533150 1751567 The EGFR inhibitor dose-dependently reduced H. pylori *induced* [ERK] phosphorylation in A431 and AGS cells . Negative_regulation EPHB2 CHUK 14604964 1209543 The antigen induced tyrosine phosphorylation of FcepsilonRI , Syk , phospholipase C-gamma (PLC-gamma) , activation of c-Jun N-terminal kinase (JNK) , extracellular signal regulated kinase ( [ERK] ) , *inhibitor* of nuclear factor kappaB kinase ( ) , and Ca++ influx were all suppressed in the cells overexpressing Cbl-b in the lipid raft . Negative_regulation EPHB2 CHUK 22733995 2639211 Unexpectedly , TPL-2 promoted soluble TNF production independently of *induced* p105 phosphorylation and its ability to activate [ERK] , which has important implications for the development of anti-inflammatory drugs targeting TPL-2 . Negative_regulation EPHB2 CIC 23733957 2801904 At the same time , we demonstrate that [ERK] *induces* ind before levels in the nucleus are reduced . Negative_regulation EPHB2 CMKLR1 22791765 2682081 Although dNK cells exhibit lower chemerin receptor ( CMKLR1 ) expression than their blood counterpart , engagement on dNK cells *resulted* in both [ERK] activation and migration through decidual ST cells . Negative_regulation EPHB2 CNP 14749356 1226335 *attenuated* basal and ET-1 augumented protein synthesis , atrial natriuretic peptide secretion , hypertrophy related gene expression , GATA-4 and MEF-2 DNA binding activities , Ca ( 2+ ) /calmodulin dependent kinase II activity , and [ERK] phosphorylation . Negative_regulation EPHB2 CNP 15869918 1411282 Conversely , and 8-bromo-cGMP strongly and dose-dependently *inhibited* the induction of [ERK] phosphorylation by FGF2 and FGF18 without changing the level of FGFR-3 , although they did not affect the phosphorylation of STAT-1 . Negative_regulation EPHB2 COL2A1 10966845 728222 Our results indicate that DEX suppressed TGF beta *induced* chondrocyte proliferation and expression , probably through selective inhibition of [ERK] integrated AP-1 activation . Negative_regulation EPHB2 CPOX 11208911 894817 However , both inhibitors *induced* activation of extracellular signal regulated kinase ( [ERK] ) in neurones and phosphorylation of heavy molecular weight neurofilaments , cytoskeletal substrates of ERK . Negative_regulation EPHB2 CPOX 14634122 1170907 Moreover , inhibition sufficient to reduce PGE levels *increased* [ERK] activity . Negative_regulation EPHB2 CREB1 18616461 1947300 Silencing of or Elk-1 significantly *increased* [ERK] activation observed after 5 min of morphine stimulation . Negative_regulation EPHB2 CREB1 19279268 2046357 Thus , when rats were re-exposed to the conditioning context for retrieval of pain experience , ERK and were reactivated in the rACC , and *inhibiting* [ERK] activation blocked the expression of F-CPA . Negative_regulation EPHB2 CREB1 21403841 2404531 In this respect , the inhibition of [ERK] phosphorylation reduces AR expression and mediated transcriptional regulation of AR *acts* as a downstream connector between the AR and ERK signaling pathways in molecular apocrine cells . Negative_regulation EPHB2 CREB3 18616461 1947301 Silencing of or Elk-1 significantly *increased* [ERK] activation observed after 5 min of morphine stimulation . Negative_regulation EPHB2 CREB3 19279268 2046358 Thus , when rats were re-exposed to the conditioning context for retrieval of pain experience , ERK and were reactivated in the rACC , and *inhibiting* [ERK] activation blocked the expression of F-CPA . Negative_regulation EPHB2 CREB5 18616461 1947299 Silencing of or Elk-1 significantly *increased* [ERK] activation observed after 5 min of morphine stimulation . Negative_regulation EPHB2 CREB5 19279268 2046356 Thus , when rats were re-exposed to the conditioning context for retrieval of pain experience , ERK and were reactivated in the rACC , and *inhibiting* [ERK] activation blocked the expression of F-CPA . Negative_regulation EPHB2 CRK 10329689 613781 Grb2 with a deleted carboxyl-terminal Src homology 3 domain partially blocked Pyk2 induced ERK and JNK pathways , whereas expression of dominant interfering mutants of p130Cas or specifically *inhibited* JNK but not [ERK] activation by Pyk2 . Negative_regulation EPHB2 CRK 12482999 1024630 It inhibited [ERK] phosphorylation , but did not *inhibit* phosphorylation . Negative_regulation EPHB2 CRK 16085674 1498807 The MAP kinase inhibitor , SB-203580 *increased* [ERK] phosphorylation and IL-8 secretion . Negative_regulation EPHB2 CRK 16291589 1526019 Thus , our results suggested that tumor induced MAPK activation and [ERK] *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation EPHB2 CRK 17146999 1497053 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase *inhibitors* , MAP kinase inhibitors , [MEK/ERK] inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to inhibit mucin secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation EPHB2 CRK 17372934 1797739 Low pressure ( 20 mmHg ) , equivalent to normal tissue pressure , increases phagocytosis by primary monocytes and PMA differentiated THP-1 macrophages , in part by FAK and [ERK] *inhibition* and activation . Negative_regulation EPHB2 CRK 18443411 1926735 Partial inhibition of phosphorylation *increased* cellular levels of MyoD and [p-ERK] in stretched C2C12 cells , along with increased myotube formation . Negative_regulation EPHB2 CRK 19737350 2247712 This effect was attributable , at least partly , to caspases inhibition , Bcl-xL induction , the activation of [ERK] and Akt signalling and *inhibition* . Negative_regulation EPHB2 CRK 20664969 2298216 Immunoblot analysis demonstrated that oridonin treatment increased expression levels of p-JNK , , p-p53 and p21 , elevated the level of cyclin B1/p-Cdc2 ( Tyr15 ) complex , and *inhibited* the expression of [p-ERK] . Negative_regulation EPHB2 CRK 21251657 2397976 The *role* of TGF-ß1 activated in inhibiting phosphorylation of [ERK] was evaluated by treating samples with SB203580 , an inhibitor of p38 activation . Negative_regulation EPHB2 CRK 24297112 2894181 Following treatment with mitogen activated protein kinase (MAPK) *inhibitors* , PD98059 ( [ERK] inhibitor ) , SP600125 ( JNK inhibitor ) and SB203580 ( inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Negative_regulation EPHB2 CRK 7481820 331975 The effects of dominant interfering or constitutively activated forms of various components of the JNK-p38 and ERK signaling pathways demonstrated that activation of JNK and and concurrent *inhibition* of [ERK] are critical for induction of apoptosis in these cells . Negative_regulation EPHB2 CRKL 11443118 850428 Overexpression of Lyn *induced* constitutive phosphorylation of CrkL and activation of [Erk] , whereas that of a Lyn mutant lacking the tyrosine kinase domain attenuated the Epo induced phosphorylation of and activation of Erk . Negative_regulation EPHB2 CSE 19299917 2064153 A chemical inhibitor of MEK1/2 or PI3K reduced phosphorylation of [ERK] or Akt , respectively , and also *inhibited* mediated MMP-9 induction . Negative_regulation EPHB2 CSK 15890337 1411485 overexpression *caused* a profound inhibition of NGF induced activation of FYN , YES , RAS , and [ERK] and inhibited neurite outgrowth , NGF stimulated integrin directed migration and blocked the NGF induced conversion of GDP-RAC to its GTP bound active state . Negative_regulation EPHB2 CSK 23707526 2806262 Selective depletion of using siRNA , or inhibition with CSK inhibitor , *led* to increased phosphorylation of Akt and [Erk] , but not p38 , upon FLT3 ligand ( FL ) stimulation . Negative_regulation EPHB2 CSK 9486662 488358 Overexpression of or the dominant negative mutant of Ras *had* no effects on Ang II-induced [ERK] activation in cardiac myocytes . Negative_regulation EPHB2 CTLA4 15972645 1424020 Expression of a B7-nonbinding mutant *inhibited* T cell proliferation , cytokine production , and TCR mediated [ERK] activation in otherwise CTLA-4-deficient T cells . Negative_regulation EPHB2 CTNNB1 19366806 2065100 We show that the complex induces EphB4 and *represses* [EphB2] , in contrast to the beta-catenin-p300 complex . Negative_regulation EPHB2 CTNND1 10329689 613782 Grb2 with a deleted carboxyl-terminal Src homology 3 domain partially blocked Pyk2 induced ERK and JNK pathways , whereas expression of dominant interfering mutants of or Crk specifically *inhibited* JNK but not [ERK] activation by Pyk2 . Negative_regulation EPHB2 CTNND1 12456636 1021297 FRNK expression disrupted the formation of a v-Src-FAK signaling complex , *inhibited* tyrosine phosphorylation , and attenuated v-Src stimulated [ERK] and JNK kinase activation . Negative_regulation EPHB2 CUL4A 18332868 1925107 Consistently , VprBP depletion abolished the in vivo interaction of Merlin and , which resulted in Merlin stabilization and *inhibited* [ERK] and Rac activation . Negative_regulation EPHB2 CXCL10 12549928 1051396 Moreover , can *inhibit* CXCL1 induced PAK1 and [ERK] activation as well as the CXCL1 induced chemotaxis through decreasing CXCL1 binding to cell surface heparan sulfate . Negative_regulation EPHB2 CXCL10 23352833 2758499 On the other hand , phosphorylation of [ERK] induced by VEGF and MCP-1 was *inhibited* by PF-4 , Mig and . Negative_regulation EPHB2 CXCL12 15816868 1393316 Stimulation of the more differentiated progenitors ( E14.5 ) with *resulted* in rapid activation of the extracellular signal regulated kinase ( [ERK] ) 1/2 . Negative_regulation EPHB2 CXCL12 23133664 2696596 Dasatinib pre-treatment inhibited Akt and [ERK] phosphorylation in CLL cells upon *stimulation* with . Negative_regulation EPHB2 CXCL2 20477948 2288586 In addition , protein kinase C inhibitors suppressed ATP induced [ERK] and JNK activation , and also *inhibited* ATP induced expression in microglia . Negative_regulation EPHB2 CXCL9 23352833 2758500 On the other hand , phosphorylation of [ERK] induced by VEGF and MCP-1 was *inhibited* by PF-4 , and IP-10 . Negative_regulation EPHB2 CXCL9 9498749 490592 Finally , agents that elevate cAMP , causing protein kinase A-mediated inhibition of Raf-1 , inhibited activation of [ERK] in *response* to cross linking , but had no affect on ERK activation in response to anti-CD40 or Jun N-terminal kinase activation by signals through either receptor . Negative_regulation EPHB2 CXCR3 11136732 795022 In MC , which respond to CXCR3 ligands with increased DNA synthesis , activation *resulted* in a biphasic stimulation of [ERK] activation , a pattern similar to the one observed in HSC exposed to platelet derived growth factor , indicating that this type of response is related to the stimulation of cell proliferation . Negative_regulation EPHB2 CXCR3 15613278 1357411 The *role* of a receptor in [Erk] phosphorylation was substantiated by the ability of CXCL11 , another potent CXCR3 ligand , to induce Erk phosphorylation in the NUB6 and SK-NMC cells . Negative_regulation EPHB2 CYSLTR1 19561298 2110643 The membrane expression of the analyzed by FACS with anti-Myc Ab was not reduced by the cotransfection , yet both LTD ( 4 ) -elicited [ERK] phosphorylation and the specific binding of [ ( 3 ) H ] LTD ( 4 ) to microsomal membranes were fully *inhibited* . Negative_regulation EPHB2 DAB2 11371563 834840 *mediated* inhibition of [ERK] phosphorylation via binding to Grb2 . Negative_regulation EPHB2 DAB2 11371563 834841 We conclude that , a potent negative regulator , can *suppress* [ERK] activation by interrupting the binding between Grb2 and SOS that is elicited by peptide growth factors . Negative_regulation EPHB2 DCT 14712208 1197010 Indeed , overexpression in a melanoma cell line *resulted* in increased [ERK] activity . Negative_regulation EPHB2 DDB1 18332868 1925108 Consistently , VprBP depletion abolished the in vivo interaction of Merlin and , which resulted in Merlin stabilization and *inhibited* [ERK] and Rac activation . Negative_regulation EPHB2 DEFA1 19730798 2183310 AMP579 induced [ERK] phosphorylation with an EC50 of 250 nM and this phosphorylation could be *blocked* by or PSB1115 , two highly selective blockers of human A2b receptors . Negative_regulation EPHB2 DKC1 12223143 987667 HRT , VCR , and Vp16 could inhibit cell proliferation ( 0.28 % 0.08 % , 0.25 % 0.16 % , 0.24 % 0.11 % ) , induce apoptosis ( 21.12 % , 28.83 % , 12.30 % ) , *inhibit* activity , and down-regulate the protein expression of phosphorylated [ERK] . Negative_regulation EPHB2 DKC1 12674761 1030443 The results showed that HRT , VCR and Vp16 could inhibit cell proliferation , induce apoptosis , *inhibit* activity and down-regulate the protein expression of phosphorylated [ERK] . Negative_regulation EPHB2 DNM1 12920215 1130944 In addition , we find that internalization of CCR2B itself is not necessary for efficient MCP-1 induced activation of ERK , although a mutant partially *inhibits* [ERK] stimulation . Negative_regulation EPHB2 DNM2 12920215 1130945 In addition , we find that internalization of CCR2B itself is not necessary for efficient MCP-1 induced activation of ERK , although a mutant partially *inhibits* [ERK] stimulation . Negative_regulation EPHB2 DNM3 12920215 1130943 In addition , we find that internalization of CCR2B itself is not necessary for efficient MCP-1 induced activation of ERK , although a mutant partially *inhibits* [ERK] stimulation . Negative_regulation EPHB2 DSG1 23524970 2761886 interaction *suppresses* [ERK] activation to support epidermal differentiation . Negative_regulation EPHB2 DUSP1 10666504 665621 This suggests that the decrease in [ERK] activity is not *mediated* through a decrease in MEK ( a dual phosphorylating kinase upstream of ERK ) or by an increase in ( a dual specificity phosphatase ) activities . Negative_regulation EPHB2 DUSP1 15096509 1258207 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP1 18682602 1967715 Moreover , inhibition of expression using siRNA technology or synthetic inhibitors also *led* to elongated [ERK] activity and significant blockage of M-CSF dependent proliferation . Negative_regulation EPHB2 DUSP1 18697198 1955463 Levels of , a specific [ERK] *inhibitor* , increased only in BN rat lesions , leading to modest ERK activation , whereas a progressive Dusp1 decline occurred in corresponding lesions from F344 rats and was accompanied by elevated ERK activation . Negative_regulation EPHB2 DUSP1 19034960 1998529 Unrestrained extracellular signal regulated kinase ( ERK ) activity linked to proteasomal degradation of , a specific [ERK] *inhibitor* , by the CKS1-SKP2 ubiquitin ligase complex occurs in more aggressive HCC of F344 rats and humans . Negative_regulation EPHB2 DUSP1 19429855 2096410 Unrestrained extracellular signal regulated kinase ( Erk ) activity linked to proteasomal degradation of , a specific [ERK] *inhibitor* , by the CKS1-SKP2 ubiquitin ligase complex was highest in more aggressive HCC of genetically susceptible rats . Negative_regulation EPHB2 DUSP1 19476641 2102353 However , the inhibition of both and MKP-3 by triptolide *induced* an increase in [p-ERK] expression and in microglial migration using LPS+JWH015 treated microglia . Negative_regulation EPHB2 DUSP1 20100175 2219231 Glucocorticoids inhibit IL-1beta induced GM-CSF expression at multiple levels : roles for the [ERK] pathway and *repression* by . Negative_regulation EPHB2 DUSP1 20100175 2219236 Since MKP-1 prevented GM-CSF expression by transcriptional , post-transcriptional and translational processes , we propose that glucocorticoids *induce* expression to reduce both [MEK/ERK] activation and GM-CSF protein synthesis . Negative_regulation EPHB2 DUSP1 20196119 2265276 ERK phosphorylates DUSP1 , facilitating its proteasomal degradation , whereas *inhibits* [ERK] activity . Negative_regulation EPHB2 DUSP1 22901764 2666571 We have previously shown that the cannabinoid type 2 receptor agonist JWH015 *inhibits* [ERK] activity by inducing and MKP-3 ( the major regulators of MAPKs ) in vitro in microglial cells . Negative_regulation EPHB2 DUSP1 9774360 539707 In addition , PD 098059 , an antagonist of MEK ( MAP kinase/ERK kinase ) , the upstream kinase of ERK , significantly reduced the PDGF induced activation of [ERK] and potently *inhibited* the expression of after stimulation with PDGF , thereby demonstrating the induction of MKP-1 in response to activation of the ERK signaling cascade . Negative_regulation EPHB2 DUSP10 15096509 1258208 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP11 15096509 1258209 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP12 15096509 1258210 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP13 15096509 1258202 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP14 15096509 1258198 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP15 15096509 1258197 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP16 11489891 868039 Forced expression of *suppressed* activation of MAPKs in COS-7 cells in the order of selectivity , JNK p38 > [ERK] . Negative_regulation EPHB2 DUSP16 15096509 1258199 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP18 15096509 1258200 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP19 15096509 1258201 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP2 15096509 1258211 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP21 15096509 1258203 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP22 15096509 1258196 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP23 15096509 1258204 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP26 15096509 1258206 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP27 15096509 1258205 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP27 23592794 2773260 In the absence of MYC , ectopic DUSP2,7 expression severely delays differentiation , while loss of ectopically *activates* [ERK] , resulting in loss of pluripotency . Negative_regulation EPHB2 DUSP28 15096509 1258219 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP3 12204117 983344 We first found that *inhibits* the activation of p38 as well as [ERK] and JNK , with similar efficiency . Negative_regulation EPHB2 DUSP3 15096509 1258212 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP4 10666504 665622 This suggests that the decrease in [ERK] activity is not *mediated* through a decrease in MEK ( a dual phosphorylating kinase upstream of ERK ) or by an increase in ( a dual specificity phosphatase ) activities . Negative_regulation EPHB2 DUSP4 15096509 1258213 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP5 15096509 1258214 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP6 15096509 1258215 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP6 15159408 1273326 These studies indicate that in initiated cells palytoxin unleashes ERK activity by down regulating , an [ERK] *inhibitor* , and further suggest that MKP-3 may be a vulnerable target in cells that express oncogenic Ras . Negative_regulation EPHB2 DUSP6 18321244 1904370 is inducible by FGF ( fibroblast growth factor ) signalling and acts as a negative *regulator* of [ERK] activity in key and discrete signalling centres that direct outgrowth and patterning in early vertebrate embryos . Negative_regulation EPHB2 DUSP6 19109160 2018903 This synergistic effect on MUC5AC production may be due to enhanced *activation* of [ERK] through inhibition of by poly ( I : Negative_regulation EPHB2 DUSP6 19476641 2102354 However , the inhibition of both MKP-1 and by triptolide *induced* an increase in [p-ERK] expression and in microglial migration using LPS+JWH015 treated microglia . Negative_regulation EPHB2 DUSP6 22901764 2666572 We have previously shown that the cannabinoid type 2 receptor agonist JWH015 *inhibits* [ERK] activity by inducing MAPK phosphatase (MKP)-1 and ( the major regulators of MAPKs ) in vitro in microglial cells . Negative_regulation EPHB2 DUSP6 9878562 557860 We found that induction of *suppressed* phosphorylation and activation of cPLA2 as well as [ERK] . Negative_regulation EPHB2 DUSP7 15096509 1258216 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP8 15096509 1258217 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP9 15096509 1258218 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Negative_regulation EPHB2 DUSP9 22305567 2552206 Through *mediated* inhibition of [ERK] activity , BMP signaling reinforces the self-renewal status of mouse ESCs together with LIF . Negative_regulation EPHB2 DYNLL1 21461354 2361532 Further , we show that pharmacological blockade of NMDAR-driven synaptic plasticity , NOS activation , or PKG signaling in the LA significantly impairs high-frequency stimulation- ( HFS- ) induced ERK activation and IEG expression in both regions , while blockade of extracellular NO signaling in the LA *impairs* HFS induced [ERK] activation and IEG expression exclusively in the . Negative_regulation EPHB2 DYNLL1 23293355 2733053 also *inhibited* RANKL induced activation of JNK and [ERK] . Negative_regulation EPHB2 E2F1 18396012 1899401 Specifically , downregulating *inhibits* PDGF induced [ERK] phosphorylation and ectopic expression of E2F1 sensitizes cells to PDGF . Negative_regulation EPHB2 EDN1 10487327 644583 activated ERKs , which were followed by an increase in protein synthesis , and inhibition of protein kinase C activities by calphostin C completely *suppressed* the ET-1 induced [ERK] activation . Negative_regulation EPHB2 EDN1 12193071 980996 induced a rapid and transient activation of Ras in renal mesangial cells , which was dependent upon the formation of the Shc/Grb2/Sos1 signalling complex and *resulted* in transient [ERK] activation . Negative_regulation EPHB2 EDNRB 24145738 2885719 In vitro experiments demonstrated that the overexpression of significantly *enhanced* the proliferation of oligodendroglioma cells and the activation of [ERK] compared with the controls , which was eliminated by the selective ETBR inhibitor BQ788 and ERK-specific inhibitor U0126 , but not selective endothelin A receptor inhibitor BQ123 . Negative_regulation EPHB2 EFNA5 18563700 1940820 These analyses showed that *inhibits* [Erk] activity but activates c-Jun N-terminal kinase . Negative_regulation EPHB2 EFNA5 22022520 2499058 *suppressed* BDNF induced [ERK] activity and might sequester P-ERK in the cytoplasm . Negative_regulation EPHB2 EFNB1 19047466 1999193 In addition , FGFR1 signaling inhibits further phosphorylation of [EphB2] upon *stimulation* with , and we show that this involves a requirement for the mitogen activated protein kinase (MAPK) pathway . Negative_regulation EPHB2 EGF 10585878 571578 However , PP2 inhibited [ERK] activation in response to NE and UTP , but not in *response* to or NGF . Negative_regulation EPHB2 EGF 10688043 669951 Inhibition of and LPA- *induced* [ERK] activation with the EGF receptor inhibitor , AG1478 , or the MEK inhibitor , PD98059 , attenuated their proliferative effects . Negative_regulation EPHB2 EGF 11134020 794909 Although the binding of to the epidermal growth factor receptor (EGFR) was decreased in GnT-III transfectants to a level of about 60 % of control cells , the EGF induced activation of extracellular signal regulated kinase ( [ERK] ) in GnT-III transfectants was *enhanced* to approximately 1.4-fold that of the control cells . Negative_regulation EPHB2 EGF 11851354 913218 *Role* of Receptor and Pyk2 in endothelin-1 induced [ERK] activation in rat cardiomyocytes . Negative_regulation EPHB2 EGF 12923167 1151227 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to fibroblast growth factor and PDGF but not the . Negative_regulation EPHB2 EGF 15640153 1381322 PGEs enhanced Erk activation and MMP-1 secretion in *response* to but inhibited [Erk] and MMP-1 when TNF-alpha and IL-1beta were the stimuli , indicating that the effects of PGEs on gastric cell responses are context dependent . Negative_regulation EPHB2 EGF 15908804 1420112 *induced* a mild effect on DNA synthesis and [ERK] activation in EGFR positive FDC-P1 cells but not EGFR negative FL5.12 cells . Negative_regulation EPHB2 EGF 17226785 1696266 However , ligand independent phosphorylation of the by removal of cholesterol precedes Ras activation , and the EGFR kinase inhibitor AG1478 *blocks* [Erk] phosphorylation , supporting occurrence of the signaling sequence EGFR-Ras-MEK-Erk . Negative_regulation EPHB2 EGF 18096367 1855023 Finally , our data showed that , with overexpression of hSef , elevated levels of [Erk] phosphorylation and differentiation of rat pheochromocytoma ( PC12 ) cells occur in *response* to stimulation . Negative_regulation EPHB2 EGF 21541969 2423922 receptor activation *inhibited* GnRH induced [ERK] activation in WPE-1-NB26 but growth-inhibition was not rescued by EGF or PKC inhibitor Ro320432 . Negative_regulation EPHB2 EGF 24003223 2851347 Eventually , GAREM2 regulates [Erk] activation in the *presence* of or insulin like growth factor 1 . Negative_regulation EPHB2 EGF 24126105 2867916 Depletion of Gab1 , using siRNA , decreased the [ERK] and Akt activation , cyclin D1 expression , and DNA synthesis in *response* to both and HGF . Negative_regulation EPHB2 EGF 8897883 392922 Also , in contrast to observations in neutrophils , the phosphatidylinositol 3-kinase ( PtdIns 3-kinase ) inhibitor , wortmannin ( 0.3-3 microM ) , failed to inhibit [ERK] activation in *response* to , carbachol , or TPA . Negative_regulation EPHB2 EGFR 11134020 794910 Although the binding of EGF to the was decreased in GnT-III transfectants to a level of about 60 % of control cells , the EGF induced activation of extracellular signal regulated kinase ( [ERK] ) in GnT-III transfectants was *enhanced* to approximately 1.4-fold that of the control cells . Negative_regulation EPHB2 EGFR 11371939 817734 Inhibition of the kinase activity of protein kinase C or eliminated BK *induced* [ERK] activation . Negative_regulation EPHB2 EGFR 11502566 847677 Addition of EGFR tyrosine kinase inhibitors ( e.g. , tyrphostin AG-1478 ) abrogated bombesin induced extracellular signal regulated kinase ( ERK ) activation in Rat-1 cells but not in Swiss 3T3 cells , indicating the importance of cell context in determining the *role* of in [ERK] activation . Negative_regulation EPHB2 EGFR 12186792 978308 In VSMCs , ( 2.5 micromol/L ) reduced EGFR expression and *inhibited* the Ang II-induced phosphorylation of [ERK] . Negative_regulation EPHB2 EGFR 14645669 1173054 However , long-term application of U69 ,593 neither down-regulated nor *inhibited* EGF induced [ERK] activation . Negative_regulation EPHB2 EGFR 15192046 1280960 Expression of a dominant interfering MEK kinase 1 (MEKK1) and Y1068F more efficiently *blocked* the enhanced [Erk] activation by BTC , compared with EGF . Negative_regulation EPHB2 EGFR 15542601 1360693 In this study , we analyzed the *role* of the in RSV activation of [ERK] . Negative_regulation EPHB2 EGFR 15677486 1369860 We found that the presence of polyQ peptides indeed abolished dEAAT1 upregulation by constitutively active and potently *inhibited* EGFR mediated [ERK] activation in fly glial cells . Negative_regulation EPHB2 EGFR 17374561 1748328 WNT3a induced [ERK] pathway *activations* were blocked by AG1478 , the inhibitor , and EGFR siRNA . Negative_regulation EPHB2 EGFR 19035474 1998589 Growth factor activation of [ERK] and JNK signaling was significantly *reduced* by . Negative_regulation EPHB2 EGFR 22457794 2578441 Suppression of MUC1 expression resulted in destabilization and *inhibition* of the BPDE induced activation of Akt and [ERK] and increase of cytotoxicity . Negative_regulation EPHB2 EGFR 22763976 2623351 Inhibition of kinase activity by AG494 in contrast to AG1478 *had* no effect on the activity of [ERK] in both cell lines . Negative_regulation EPHB2 ENG 20884686 2347332 Interestingly , in spindle carcinoma cells , that have a hyperactivated Ras/MAPK pathway , *inhibited* [ERK] phosphorylation without affecting MEK or Ras activity . Negative_regulation EPHB2 ENO2 20839643 2319124 Further , the phosphorylation of p38 , [ERK] and JNK was *suppressed* by in a concentration dependent manner . Negative_regulation EPHB2 EPC1 22146405 2515415 Furthermore , significantly *inhibited* the Ang II-induced phosphorylation of [ERK] , JNK , p38 , and p65 ( nuclear translocation of p65 ) and the expressions of c-myc and c-fos . Negative_regulation EPHB2 EPC2 22146405 2515416 Furthermore , significantly *inhibited* the Ang II-induced phosphorylation of [ERK] , JNK , p38 , and p65 ( nuclear translocation of p65 ) and the expressions of c-myc and c-fos . Negative_regulation EPHB2 EPHA3 20434485 2274734 The results demonstrate that taspine can down-regulate phosphorylation of FGFR1 and [ERK] , and *inhibit* and MCF-7 cell proliferation . Negative_regulation EPHB2 EPHB6 16443753 1517004 In the outer medulla , however , [EphB2] signaling may be *attenuated* by the co-expressed kinase-inactive receptor . Negative_regulation EPHB2 EPS8 23203811 2757636 interacts with the clathrin mediated endocytosis machinery and depletion of Eps8 *inhibits* FGFR trafficking and immediate [Erk] signalling . Negative_regulation EPHB2 EPX 21074785 2546432 *diminished* [Erk] phosphorylation to almost the same extent in both mouse strains . Negative_regulation EPHB2 ERBB2 10648571 662101 Overexpression of in cells devoid of other ErbB receptor members is *sufficient* to promote [ERK] activation and CAS/Crk coupling , leading to cell migration . Negative_regulation EPHB2 ERBB2 22988345 2674394 Downregulation of via siRNA *resulted* in a significant decrease in [ERK] phosphorylation and a 50 % reduction in IL-8 secretion . Negative_regulation EPHB2 ERBB2IP 12379659 1034791 In contrast , expression of greatly *impairs* activation of [Erk] , but not Akt , by ligands that activate receptor tyrosine kinases . Negative_regulation EPHB2 ERBB2IP 12379659 1034795 Moreover , *inhibits* the [Erk] activation by active Ras , while it fails to do so in the presence of active Raf-1 . Negative_regulation EPHB2 ERBB2IP 15659388 1381924 Reducing expression using a targeted siRNA in primary cultures of Schwann cells *results* in altered cell-cell interactions , disruption of E-cadherin adherens junctions , increased cell proliferation , and elevated levels of phosphorylated [ERK] , all phenotypes observed in cells that lack merlin . Negative_regulation EPHB2 ERBB2IP 16301319 1511038 These results demonstrate a regulatory role of Erbin in the Ras-Raf-MEK pathway , suggesting that may *inhibit* [ERK] activation by disrupting the Sur-8-Ras/Raf interaction . Negative_regulation EPHB2 ERBB2IP 22116522 2591722 Importantly , elevated expression of *inhibited* [ERK] signaling and partial reversed EMT stimulated by TGF-ß1 . Negative_regulation EPHB2 ERBB2IP 23524970 2761885 interaction *suppresses* [ERK] activation to support epidermal differentiation . Negative_regulation EPHB2 ERBB2IP 23711387 2801637 The inhibitory *role* of in [ERK] signaling has been demonstrated . Negative_regulation EPHB2 ERBB2IP 24711380 2935543 It is known that *inhibits* Ras mediated activation of the extracellular signal regulated kinase ( [ERK] ) by binding to Soc-2 suppressor of clear homolog ( Shoc2 ) . Negative_regulation EPHB2 F2RL1 16336275 1491303 further , desensitization of with a brief exposure of cells to PAR-2 AP *resulted* in inhibition of HAT induced [ERK] phosphorylation , suggesting that HAT activates ERK through PAR-2 . Negative_regulation EPHB2 FADD 16129431 1461139 This conclusion is based on the following observations : ( I ) Overexpression of , caspase-8 , or a c-FLIP protein containing the death effector domains only *leads* to enhanced and prolonged [ERK] activation after TNF treatment . Negative_regulation EPHB2 FAS 21227941 2386697 GdA up-regulated the expression of and *inhibited* [ERK] activation in the Th-1 cells , which might enhance the vulnerability of the cells to cell death caused by a trophoblast derived FasL . Negative_regulation EPHB2 FAS 21390183 2400552 Overexpression of in the adenocarcinoma cell lines induced robust apoptosis and , under conditions of pan-caspase inhibition , *resulted* in activation of [ERK] signaling . Negative_regulation EPHB2 FAS 25086185 2956909 Surprisingly , in *response* to suppression , we observed robust increases in both Akt and [ERK] phosphorylation . Negative_regulation EPHB2 FASN 25086185 2956901 Inhibition of *induces* pro-survival Akt and [ERK] signaling in K-Ras-driven cancer cells . Negative_regulation EPHB2 FCER1G 19356729 2081123 Exposure to celastrol inhibited the interaction between immunoglobulin Fc epsilon receptor I ( FcepsilonRIgamma ) and [ERK] and *inhibited* interaction between and protein kinase C delta (PKCdelta) . Negative_regulation EPHB2 FCGR2A 10843711 700196 Homotypic and heterotypic cross linking of and/or Fc gamma RIIIb *resulted* in a rapid , transient increase in [ERK] and p38 activity , with maximal stimulation between 1 and 3 min . Fc gamma RIIa and Fc gamma RIIIb stimulated distinct patterns of ERK and p38 activity , and heterotypic cross linking failed to stimulate synergistic activation of either ERK or p38 activity . Negative_regulation EPHB2 FCGR3B 10843711 700197 Homotypic and heterotypic cross linking of Fc gamma RIIa and/or *resulted* in a rapid , transient increase in [ERK] and p38 activity , with maximal stimulation between 1 and 3 min . Fc gamma RIIa and Fc gamma RIIIb stimulated distinct patterns of ERK and p38 activity , and heterotypic cross linking failed to stimulate synergistic activation of either ERK or p38 activity . Negative_regulation EPHB2 FGF1 12923167 1151228 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Negative_regulation EPHB2 FGF1 17299056 1711309 mediated inhibition of Shh responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 FGF1 21889435 2510496 Overexpression of MPS-1 resulted in decreased ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Negative_regulation EPHB2 FGF1 23906837 2870884 Consistent with our hypothesis , ectopic activation of signaling resulted in decreased cell proliferation , increased expression of the Sprouty class of FGF signaling inhibitors , and *repressed* phosphorylation of [ERK/MAPK] . Negative_regulation EPHB2 FGF10 12923167 1151229 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Negative_regulation EPHB2 FGF10 17299056 1711310 mediated inhibition of Shh responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 FGF10 21889435 2510497 Overexpression of MPS-1 resulted in decreased ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Negative_regulation EPHB2 FGF10 23906837 2870885 Consistent with our hypothesis , ectopic activation of signaling resulted in decreased cell proliferation , increased expression of the Sprouty class of FGF signaling inhibitors , and *repressed* phosphorylation of [ERK/MAPK] . Negative_regulation EPHB2 FGF11 12923167 1151230 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Negative_regulation EPHB2 FGF11 17299056 1711311 mediated inhibition of Shh responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 FGF11 21889435 2510498 Overexpression of MPS-1 resulted in decreased ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Negative_regulation EPHB2 FGF11 23906837 2870886 Consistent with our hypothesis , ectopic activation of signaling resulted in decreased cell proliferation , increased expression of the Sprouty class of FGF signaling inhibitors , and *repressed* phosphorylation of [ERK/MAPK] . Negative_regulation EPHB2 FGF12 12923167 1151231 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Negative_regulation EPHB2 FGF12 17299056 1711312 mediated inhibition of Shh responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 FGF12 21889435 2510499 Overexpression of MPS-1 resulted in decreased ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Negative_regulation EPHB2 FGF12 23906837 2870887 Consistent with our hypothesis , ectopic activation of signaling resulted in decreased cell proliferation , increased expression of the Sprouty class of FGF signaling inhibitors , and *repressed* phosphorylation of [ERK/MAPK] . Negative_regulation EPHB2 FGF13 12923167 1151232 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Negative_regulation EPHB2 FGF13 17299056 1711313 mediated inhibition of Shh responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 FGF13 21889435 2510500 Overexpression of MPS-1 resulted in decreased ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Negative_regulation EPHB2 FGF13 23906837 2870888 Consistent with our hypothesis , ectopic activation of signaling resulted in decreased cell proliferation , increased expression of the Sprouty class of FGF signaling inhibitors , and *repressed* phosphorylation of [ERK/MAPK] . Negative_regulation EPHB2 FGF14 12923167 1151233 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Negative_regulation EPHB2 FGF14 17299056 1711314 mediated inhibition of Shh responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 FGF14 21889435 2510501 Overexpression of MPS-1 resulted in decreased ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Negative_regulation EPHB2 FGF14 23906837 2870889 Consistent with our hypothesis , ectopic activation of signaling resulted in decreased cell proliferation , increased expression of the Sprouty class of FGF signaling inhibitors , and *repressed* phosphorylation of [ERK/MAPK] . Negative_regulation EPHB2 FGF16 12923167 1151234 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Negative_regulation EPHB2 FGF16 17299056 1711315 mediated inhibition of Shh responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 FGF16 21889435 2510502 Overexpression of MPS-1 resulted in decreased ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Negative_regulation EPHB2 FGF16 23906837 2870890 Consistent with our hypothesis , ectopic activation of signaling resulted in decreased cell proliferation , increased expression of the Sprouty class of FGF signaling inhibitors , and *repressed* phosphorylation of [ERK/MAPK] . Negative_regulation EPHB2 FGF17 12923167 1151235 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Negative_regulation EPHB2 FGF17 17299056 1711316 mediated inhibition of Shh responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 FGF17 21889435 2510503 Overexpression of MPS-1 resulted in decreased ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Negative_regulation EPHB2 FGF17 23906837 2870891 Consistent with our hypothesis , ectopic activation of signaling resulted in decreased cell proliferation , increased expression of the Sprouty class of FGF signaling inhibitors , and *repressed* phosphorylation of [ERK/MAPK] . Negative_regulation EPHB2 FGF18 12923167 1151236 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Negative_regulation EPHB2 FGF18 17299056 1711317 mediated inhibition of Shh responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 FGF18 21889435 2510504 Overexpression of MPS-1 resulted in decreased ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Negative_regulation EPHB2 FGF18 23906837 2870892 Consistent with our hypothesis , ectopic activation of signaling resulted in decreased cell proliferation , increased expression of the Sprouty class of FGF signaling inhibitors , and *repressed* phosphorylation of [ERK/MAPK] . Negative_regulation EPHB2 FGF19 12923167 1151237 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Negative_regulation EPHB2 FGF19 17299056 1711318 mediated inhibition of Shh responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 FGF19 21889435 2510505 Overexpression of MPS-1 resulted in decreased ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Negative_regulation EPHB2 FGF19 23906837 2870893 Consistent with our hypothesis , ectopic activation of signaling resulted in decreased cell proliferation , increased expression of the Sprouty class of FGF signaling inhibitors , and *repressed* phosphorylation of [ERK/MAPK] . Negative_regulation EPHB2 FGF2 12923167 1151238 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Negative_regulation EPHB2 FGF2 17299056 1711319 mediated inhibition of Shh responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 FGF2 17763874 1817241 All three growth factors were shown to phosphorylate immediately extracellular-signal regulated kinases ( ERKs ) , while the stimulation by especially *resulted* in sustained [ERK] phosphorylation . Negative_regulation EPHB2 FGF2 20024612 2315203 In cells with amplified FGFR-1 , brivanib decreased receptor autophosphorylation , *inhibited* induced tyrosine kinase activity , and reduced phosphorylation of [ERK] and AKT . Negative_regulation EPHB2 FGF2 21663947 2459742 We found that the hSef expression was positively regulated by induced MAPK/ERK signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation EPHB2 FGF2 21889435 2510506 Overexpression of MPS-1 resulted in decreased ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Negative_regulation EPHB2 FGF2 23906837 2870894 Consistent with our hypothesis , ectopic activation of signaling resulted in decreased cell proliferation , increased expression of the Sprouty class of FGF signaling inhibitors , and *repressed* phosphorylation of [ERK/MAPK] . Negative_regulation EPHB2 FGF2 24445144 2942452 Moreover , knockdown of brachyury by small hairpin RNA reduced FGF2 secretion , *inhibited* [FGFR/MEK/ERK] phosphorylation and blocked the effects of on cell growth , apoptosis and EMT . Negative_regulation EPHB2 FGF20 12923167 1151239 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Negative_regulation EPHB2 FGF20 17299056 1711320 mediated inhibition of Shh responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 FGF20 21889435 2510507 Overexpression of MPS-1 resulted in decreased ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Negative_regulation EPHB2 FGF20 23906837 2870895 Consistent with our hypothesis , ectopic activation of signaling resulted in decreased cell proliferation , increased expression of the Sprouty class of FGF signaling inhibitors , and *repressed* phosphorylation of [ERK/MAPK] . Negative_regulation EPHB2 FGF21 12923167 1151240 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Negative_regulation EPHB2 FGF21 17299056 1711321 mediated inhibition of Shh responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 FGF21 21889435 2510508 Overexpression of MPS-1 resulted in decreased ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Negative_regulation EPHB2 FGF21 23906837 2870896 Consistent with our hypothesis , ectopic activation of signaling resulted in decreased cell proliferation , increased expression of the Sprouty class of FGF signaling inhibitors , and *repressed* phosphorylation of [ERK/MAPK] . Negative_regulation EPHB2 FGF22 12923167 1151241 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Negative_regulation EPHB2 FGF22 17299056 1711322 mediated inhibition of Shh responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 FGF22 21889435 2510509 Overexpression of MPS-1 resulted in decreased ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Negative_regulation EPHB2 FGF22 23906837 2870897 Consistent with our hypothesis , ectopic activation of signaling resulted in decreased cell proliferation , increased expression of the Sprouty class of FGF signaling inhibitors , and *repressed* phosphorylation of [ERK/MAPK] . Negative_regulation EPHB2 FGF23 12923167 1151242 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Negative_regulation EPHB2 FGF23 17299056 1711323 mediated inhibition of Shh responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 FGF23 21889435 2510510 Overexpression of MPS-1 resulted in decreased ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Negative_regulation EPHB2 FGF23 23906837 2870898 Consistent with our hypothesis , ectopic activation of signaling resulted in decreased cell proliferation , increased expression of the Sprouty class of FGF signaling inhibitors , and *repressed* phosphorylation of [ERK/MAPK] . Negative_regulation EPHB2 FGF3 12923167 1151243 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Negative_regulation EPHB2 FGF3 17299056 1711324 mediated inhibition of Shh responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 FGF3 21889435 2510511 Overexpression of MPS-1 resulted in decreased ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Negative_regulation EPHB2 FGF3 23906837 2870899 Consistent with our hypothesis , ectopic activation of signaling resulted in decreased cell proliferation , increased expression of the Sprouty class of FGF signaling inhibitors , and *repressed* phosphorylation of [ERK/MAPK] . Negative_regulation EPHB2 FGF4 12923167 1151244 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Negative_regulation EPHB2 FGF4 17299056 1711325 mediated inhibition of Shh responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 FGF4 21889435 2510512 Overexpression of MPS-1 resulted in decreased ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Negative_regulation EPHB2 FGF4 23906837 2870900 Consistent with our hypothesis , ectopic activation of signaling resulted in decreased cell proliferation , increased expression of the Sprouty class of FGF signaling inhibitors , and *repressed* phosphorylation of [ERK/MAPK] . Negative_regulation EPHB2 FGF5 12923167 1151245 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Negative_regulation EPHB2 FGF5 17299056 1711326 mediated inhibition of Shh responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 FGF5 21889435 2510513 Overexpression of MPS-1 resulted in decreased ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Negative_regulation EPHB2 FGF5 23906837 2870901 Consistent with our hypothesis , ectopic activation of signaling resulted in decreased cell proliferation , increased expression of the Sprouty class of FGF signaling inhibitors , and *repressed* phosphorylation of [ERK/MAPK] . Negative_regulation EPHB2 FGF6 12923167 1151246 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Negative_regulation EPHB2 FGF6 17299056 1711327 mediated inhibition of Shh responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 FGF6 21889435 2510514 Overexpression of MPS-1 resulted in decreased ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Negative_regulation EPHB2 FGF6 23906837 2870902 Consistent with our hypothesis , ectopic activation of signaling resulted in decreased cell proliferation , increased expression of the Sprouty class of FGF signaling inhibitors , and *repressed* phosphorylation of [ERK/MAPK] . Negative_regulation EPHB2 FGF7 12923167 1151247 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Negative_regulation EPHB2 FGF7 17299056 1711328 mediated inhibition of Shh responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 FGF7 21889435 2510515 Overexpression of MPS-1 resulted in decreased ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Negative_regulation EPHB2 FGF7 23906837 2870903 Consistent with our hypothesis , ectopic activation of signaling resulted in decreased cell proliferation , increased expression of the Sprouty class of FGF signaling inhibitors , and *repressed* phosphorylation of [ERK/MAPK] . Negative_regulation EPHB2 FGF8 12923167 1151248 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Negative_regulation EPHB2 FGF8 17299056 1711329 mediated inhibition of Shh responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 FGF8 21889435 2510516 Overexpression of MPS-1 resulted in decreased ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Negative_regulation EPHB2 FGF8 23906837 2870904 Consistent with our hypothesis , ectopic activation of signaling resulted in decreased cell proliferation , increased expression of the Sprouty class of FGF signaling inhibitors , and *repressed* phosphorylation of [ERK/MAPK] . Negative_regulation EPHB2 FGF9 12923167 1151249 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Negative_regulation EPHB2 FGF9 17299056 1711330 mediated inhibition of Shh responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 FGF9 21889435 2510517 Overexpression of MPS-1 resulted in decreased ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Negative_regulation EPHB2 FGF9 23906837 2870905 Consistent with our hypothesis , ectopic activation of signaling resulted in decreased cell proliferation , increased expression of the Sprouty class of FGF signaling inhibitors , and *repressed* phosphorylation of [ERK/MAPK] . Negative_regulation EPHB2 FGFR1 11373272 817845 The ( p ) Y peptide did not *inhibit* phosphorylation of p90/FRS2 or [Erk] , suggesting that it does not act by inhibiting the Erk-kinase cascade . Negative_regulation EPHB2 FGFR1 15564375 1341426 FRS2 dependent SRC activation is required for *induced* phosphorylation of Sprouty and suppression of [ERK] activity . Negative_regulation EPHB2 FGFR1 17368052 1760148 The loading response was assessed by the activation of [ERK] , in the *presence* or absence of a specific inhibitor . Negative_regulation EPHB2 FGFR1 19047466 1999194 In addition , signaling *inhibits* further phosphorylation of [EphB2] upon stimulation with ephrinB1 , and we show that this involves a requirement for the mitogen activated protein kinase (MAPK) pathway . Negative_regulation EPHB2 FGFR1 20024612 2315204 In cells with amplified , brivanib decreased receptor autophosphorylation , inhibited bFGF induced tyrosine kinase activity , and *reduced* phosphorylation of [ERK] and AKT . Negative_regulation EPHB2 FGFR1 20434485 2274735 The results demonstrate that taspine can down-regulate phosphorylation of FGFR1 and [ERK] , and *inhibit* and MCF-7 cell proliferation . Negative_regulation EPHB2 FGFR1 23059005 2716693 Moreover , we showed that Ru-SeNPs *inhibited* the activations of and its downstream protein kinases , such [ErK] and AKT . Negative_regulation EPHB2 FGFR2 11373272 817846 The ( p ) Y peptide did not *inhibit* phosphorylation of p90/FRS2 or [Erk] , suggesting that it does not act by inhibiting the Erk-kinase cascade . Negative_regulation EPHB2 FGFR2 15564375 1341427 FRS2 dependent SRC activation is required for *induced* phosphorylation of Sprouty and suppression of [ERK] activity . Negative_regulation EPHB2 FGFR2 17368052 1760149 The loading response was assessed by the activation of [ERK] , in the *presence* or absence of a specific inhibitor . Negative_regulation EPHB2 FGFR3 11373272 817847 The ( p ) Y peptide did not *inhibit* phosphorylation of p90/FRS2 or [Erk] , suggesting that it does not act by inhibiting the Erk-kinase cascade . Negative_regulation EPHB2 FGFR3 15564375 1341428 FRS2 dependent SRC activation is required for *induced* phosphorylation of Sprouty and suppression of [ERK] activity . Negative_regulation EPHB2 FGFR3 17368052 1760150 The loading response was assessed by the activation of [ERK] , in the *presence* or absence of a specific inhibitor . Negative_regulation EPHB2 FGFR4 11373272 817848 The ( p ) Y peptide did not *inhibit* phosphorylation of p90/FRS2 or [Erk] , suggesting that it does not act by inhibiting the Erk-kinase cascade . Negative_regulation EPHB2 FGFR4 15564375 1341429 FRS2 dependent SRC activation is required for *induced* phosphorylation of Sprouty and suppression of [ERK] activity . Negative_regulation EPHB2 FGFR4 17368052 1760151 The loading response was assessed by the activation of [ERK] , in the *presence* or absence of a specific inhibitor . Negative_regulation EPHB2 FHL2 18356303 1925343 Our findings point to a *role* of in bundling of focal adhesion structures , in integrin mediated [ERK] activation , and subsequently in proper allocation of matrix proteins on the cell surface . Negative_regulation EPHB2 FNTA 11960991 953700 By contrast inhibition of Ras , by inhibition of ( Ftase-1 ) or dominant negative ( N17 ) -Ras , significantly inhibited both E ( 2 ) - and TGF alpha induced [Erk] *activation* . Negative_regulation EPHB2 FNTB 11960991 953701 By contrast inhibition of Ras , by inhibition of ( Ftase-1 ) or dominant negative ( N17 ) -Ras , significantly inhibited both E ( 2 ) - and TGF alpha induced [Erk] *activation* . Negative_regulation EPHB2 FOLR2 15488492 1321165 After 8 h of NMDA treatment , we observed FBP induced inhibition of the production of intracellular ROS , and at the earlier time *suppressed* NMDA induced p-p38 and [p-ERK] expression . Negative_regulation EPHB2 FOXM1 19136513 2053789 Conversely , suppression *led* to decreased [ERK] activity , reduced proliferation and angiogenesis , and massive apoptosis of human HCC cell lines . Negative_regulation EPHB2 FPR2 18174366 1883374 interaction *results* in cAMP independent [PI-3K/ERK] activation with downstream integrin up-regulation . Negative_regulation EPHB2 FRS2 15564375 1341425 dependent SRC activation is *required* for fibroblast growth factor receptor induced phosphorylation of Sprouty and suppression of [ERK] activity . Negative_regulation EPHB2 FRS3 16702953 1631389 We previously reported that is not tyrosine phosphorylated significantly in response to epidermal growth factor (EGF) but that it *inhibits* [ERK] activation via EGF stimulation by forming a complex with ERK2 . Negative_regulation EPHB2 FYN 15886210 1433052 Small interfering RNA also *suppressed* 2-AG induced [ERK] phosphorylation . Negative_regulation EPHB2 GAB1 14665621 1210823 Importantly , *blocked* paxillin-SHP2 complex formation , Src Tyr-530 dephosphorylation , [Erk] activation , and cell migration induced by EGF . Negative_regulation EPHB2 GAB1 15952937 1452245 Expression of either SHP2 binding defective or Gab2 mutant *blocked* EGF induced [ERK] activation . Negative_regulation EPHB2 GAB2 11895767 920767 Biochemical analyses revealed that enforced expression of mutant molecules dramatically *reduced* beta ( 1 ) -integrin ligation triggered PI3 kinase activation , whereas [Erk] kinase activation remained unaltered . Negative_regulation EPHB2 GAB2 15952937 1452244 Expression of either SHP2 binding defective Gab1 or mutant *blocked* EGF induced [ERK] activation . Negative_regulation EPHB2 GABRA1 12223228 987718 These results indicate that ethanol 's inhibitory effect on [ERK] phosphorylation may *involve* the modulation of function . Negative_regulation EPHB2 GABRB2 12223228 987719 These results indicate that ethanol 's inhibitory effect on [ERK] phosphorylation may *involve* the modulation of function . Negative_regulation EPHB2 GABRG2 12223228 987720 These results indicate that ethanol 's inhibitory effect on [ERK] phosphorylation may *involve* the modulation of function . Negative_regulation EPHB2 GADD45B 16528573 1549436 In INS-1E and beta-TC3 cells , expression of *inhibited* IL-1beta induced activation of JNK and [ERK] , but augmented IL-1beta mediated p38 activity . Negative_regulation EPHB2 GAPDH 22964641 2827279 Concurrent nuclear accumulation and [ERK] *inhibition* were required , however , to induce a significant DNA damage response , which was critical to subsequent cell death . Negative_regulation EPHB2 GAS6 10435635 634399 We further show evidence that stimulation of serum starved NIH3T3 cells *results* in a transient [ERK] , JNK/SAPK and p38 MAPK activation . Negative_regulation EPHB2 GDA 21227941 2386698 up-regulated the expression of Fas and *inhibited* [ERK] activation in the Th-1 cells , which might enhance the vulnerability of the cells to cell death caused by a trophoblast derived FasL . Negative_regulation EPHB2 GDF15 12514175 1063800 Low K ( + ) *induced* delayed and persistent [ERK] activation , which was blocked by MEK inhibitors or . Negative_regulation EPHB2 GHSR 23921150 2854969 Pretreatment of cells with the ERK inhibitor PD98059 , PI3K inhibitor LY294002 , and *blocked* the ghrelin induced activation of [ERK] and AKT , respectively ; Negative_regulation EPHB2 GJA8 21056074 2370799 The results showed that stimulated type I procollagen expression , inhibited MMP-1 , -3 , -9 expression and *inhibited* the phosphorylation of JNK , [ERK] and p38 . Negative_regulation EPHB2 GNA12 8702875 376086 Constitutively active ( GTPase-deficient ) and Galpha13 both *inhibit* [ERK] pathway activation by epidermal growth factor . Negative_regulation EPHB2 GNA13 8702875 376087 Constitutively active ( GTPase-deficient ) Galpha12 and both *inhibit* [ERK] pathway activation by epidermal growth factor . Negative_regulation EPHB2 GNB2L1 17908799 1824547 We found that associated with the core kinases of the ERK pathway , Raf , MEK , and ERK , and that attenuation of RACK1 expression *resulted* in a decrease in [ERK] activity in response to adhesion but not in response to growth factors . Negative_regulation EPHB2 GNRH1 16141398 1482384 In contrast , stimulation with continuous ( 10 nM ) in perifused cells *resulted* in a more sustained activation of [ERK] . Negative_regulation EPHB2 GNRH2 20529558 2271418 Furthermore , Triptorelin and *inhibited* the AKT and [ERK] activity in HEC-1A-ND cells . Negative_regulation EPHB2 GP2 21713380 2460846 The results showed that SJSZ ( 50 µg/ml ) *suppressed* the production of intracellular ROS and the phosphorylation of [ERK] , JNK and p38 MAPK , as well as the activities of transcriptional factors ( NF-?B and AP-1 ) , COX-2 , iNOS , and MMP-9 in TPA induced HepG2 cells . Negative_regulation EPHB2 GP2 22012075 2539745 With regard to proliferation related signals , our finding indicated that SJSZ ( 50 µg/ml ) *diminished* the production of intracellular ROS , activity of phosphorylated [ERK] , p38 MAPK , NF-?B ( p50 and p65 ) , PCNA , and cyclin D1/CDK4 in MNNG induced BNL CL.2 cells . Negative_regulation EPHB2 GP2 22547200 2618728 The results obtained from this study demonstrated that the SJSZ ( 50 µg/ml ) *inhibits* expression of JNK , [ERK] , NF-?B , and the expression of COX-2 , iNOS , and IL-1ß . Negative_regulation EPHB2 GP5 21713380 2460847 The results showed that SJSZ ( 50 µg/ml ) *suppressed* the production of intracellular ROS and the phosphorylation of [ERK] , JNK and p38 MAPK , as well as the activities of transcriptional factors ( NF-?B and AP-1 ) , COX-2 , iNOS , and MMP-9 in TPA induced HepG2 cells . Negative_regulation EPHB2 GP5 22012075 2539746 With regard to proliferation related signals , our finding indicated that SJSZ ( 50 µg/ml ) *diminished* the production of intracellular ROS , activity of phosphorylated [ERK] , p38 MAPK , NF-?B ( p50 and p65 ) , PCNA , and cyclin D1/CDK4 in MNNG induced BNL CL.2 cells . Negative_regulation EPHB2 GP5 22547200 2618729 The results obtained from this study demonstrated that the SJSZ ( 50 µg/ml ) *inhibits* expression of JNK , [ERK] , NF-?B , and the expression of COX-2 , iNOS , and IL-1ß . Negative_regulation EPHB2 GP6 21713380 2460845 The results showed that SJSZ ( 50 µg/ml ) *suppressed* the production of intracellular ROS and the phosphorylation of [ERK] , JNK and p38 MAPK , as well as the activities of transcriptional factors ( NF-?B and AP-1 ) , COX-2 , iNOS , and MMP-9 in TPA induced HepG2 cells . Negative_regulation EPHB2 GP6 22012075 2539744 With regard to proliferation related signals , our finding indicated that SJSZ ( 50 µg/ml ) *diminished* the production of intracellular ROS , activity of phosphorylated [ERK] , p38 MAPK , NF-?B ( p50 and p65 ) , PCNA , and cyclin D1/CDK4 in MNNG induced BNL CL.2 cells . Negative_regulation EPHB2 GP6 22547200 2618727 The results obtained from this study demonstrated that the SJSZ ( 50 µg/ml ) *inhibits* expression of JNK , [ERK] , NF-?B , and the expression of COX-2 , iNOS , and IL-1ß . Negative_regulation EPHB2 GP9 21713380 2460848 The results showed that SJSZ ( 50 µg/ml ) *suppressed* the production of intracellular ROS and the phosphorylation of [ERK] , JNK and p38 MAPK , as well as the activities of transcriptional factors ( NF-?B and AP-1 ) , COX-2 , iNOS , and MMP-9 in TPA induced HepG2 cells . Negative_regulation EPHB2 GP9 22012075 2539747 With regard to proliferation related signals , our finding indicated that SJSZ ( 50 µg/ml ) *diminished* the production of intracellular ROS , activity of phosphorylated [ERK] , p38 MAPK , NF-?B ( p50 and p65 ) , PCNA , and cyclin D1/CDK4 in MNNG induced BNL CL.2 cells . Negative_regulation EPHB2 GP9 22547200 2618730 The results obtained from this study demonstrated that the SJSZ ( 50 µg/ml ) *inhibits* expression of JNK , [ERK] , NF-?B , and the expression of COX-2 , iNOS , and IL-1ß . Negative_regulation EPHB2 GPI 11171046 783700 Inhibition of Ca ( 2+ ) fluxes using BAPTA/AM [ 1,2-bis- ( o-aminophenoxy ) ethane-N , N,N ' , N'-tetra-acetic acid tetrakis ( acetoxymethyl ester ) ] blocked VEGF induced ( 2 ) production but did not *inhibit* [ERK] activation . Negative_regulation EPHB2 GPI 11171046 783706 Wortmannin partially inhibited VEGF stimulation of ( 2 ) production , but did not *inhibit* VEGF induced [ERK] activity . Negative_regulation EPHB2 GPI 14963006 1227898 or iloprost at the IP receptor *inhibited* basal [ERK] phosphorylation with IC50 values of 10 nmol/L. Iloprost also attenuated the sustained activation of ERK induced by endothelin-1 or basic fibroblast growth factor (bFGF) . Negative_regulation EPHB2 GPI 19595442 2208826 ( 2 ) *inhibited* [ERK/p38] ( MAPK ) phosphorylation in response to both agonists which was unaffected by a cPLA(2) inhibitor ( AACOCF ( 3 ) ) . Negative_regulation EPHB2 GPX1 23007029 2706384 overexpression prevented both the global and nuclear increase in activated ERK at 0.5 h after HPC and *caused* a significant decrease in [phospho-ERK] ( pERK ) /ERK levels at 24 h after HPC . Negative_regulation EPHB2 GRAP2 11490356 845657 These data show that inhibition *enhances* [ERK] activity during endotoxemia . Negative_regulation EPHB2 GRAP2 12112010 963582 Moreover , inhibition *upregulates* JNK and [ERK] activity in M1 cells and in thioglycollate elicited peritoneal exudate macrophages . Negative_regulation EPHB2 GRAP2 12559954 1052718 A specific inhibitor SB 203580 also *stimulated* [ERK] activation and cell survival . Negative_regulation EPHB2 GRAP2 12876385 1115386 Cell pre-incubation with p38 inhibitors indicated that [ERK] activation by H ( 2 ) O ( 2 ) is *prevented* by concomitant activation of . Negative_regulation EPHB2 GRAP2 15610507 1348257 The heat shock induced MMP-1 and MMP-3 expression was suppressed by the inhibition of [ERK] and JNK but not by MAPK *inhibition* . Negative_regulation EPHB2 GRAP2 15808658 1391231 A significant increase in liver regeneration , as assessed by the percentage of liver weight/body weight was demonstrated in females ( 184 % +/- 24 % ) and male mice given 17beta-E ( 168 % +/- 22 % ) compared with male mice given vehicle ( 9 % +/- 4 % ) . 17beta-E significantly down-regulated JNK and activities , whereas I/R-I *promoted* p38beta and [ERK] activation . Negative_regulation EPHB2 GRAP2 15964118 1428213 In addition , the malvidin treatment significantly increased the kinase expression and *inhibited* the [ERK] activity , and the effects of malvidin on caspase-3 activation were blocked , respectively , by the ERK and p38 inhibitors . Negative_regulation EPHB2 GRAP2 16464862 1548085 In contrast , MAPK inhibitors *had* no detectable effect on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Negative_regulation EPHB2 GRAP2 17475625 1761387 MEK inhibitors UO126 and PD98059 inhibited both CagA independent and -dependent MMP-1 secretion , whereas inhibition *enhanced* MMP-1 secretion and [ERK] activation , suggesting p38 negative regulation of MMP-1 and ERK . Negative_regulation EPHB2 GRAP2 17658517 1776371 Under senescence inducing condition , decreased [Erk] phosphorylation was detected in caRhoA transfected cells and inactivation of Erk , but not , *prevented* doxorubicin induced cell senescence . Negative_regulation EPHB2 GRAP2 18314537 1919453 More specifically , was constitutively active and [ERK] activation was *suppressed* . Negative_regulation EPHB2 GRAP2 21566137 2449501 TER reduction could be attenuated by inhibiting Ras , [Erk] and Src activation , or blocking VDCC or VEGF-R2 activation , but not by *inhibiting* . Negative_regulation EPHB2 GRAP2 21687934 2455555 CFA induced phosphorylation of the [ERK] was inhibited by both dizocilpine and EA , but that of was *inhibited* by EA only . Negative_regulation EPHB2 GRAP2 22700586 2633797 Two factors that promote chondrocyte differentiation , brain derived neurotrophic factor (BDNF) and C-type natriuretic peptide , increase activity while decreasing , but not completely *inhibiting* , [ERK] activity . Negative_regulation EPHB2 GRAP2 22859305 2677295 deficiency also inhibits the activation of Akt but *enhances* the activation of [ERK] in response to T cell receptor engagement without impacting IL-2/Stat5 signaling . Negative_regulation EPHB2 GRAP2 23560534 2782968 Western blot confirmed that ruxolitinib blocked [ERK] , and consequently STAT5 activation , sorafenib *inhibited* ERK , and STAT5 , dasatinib blocked SRC and STAT5 , and KNK437 decreased the stability of the JAK2 protein , reducing its expression . Negative_regulation EPHB2 GRAP2 23836897 2829280 From an investigation of conditional gene knock-out mice , we find that epithelial-specific loss of the protein kinase *leads* to aberrant activation of TAK1 , JNK , EGF receptor , and [ERK] in distinct microanatomical areas of the intestines and skin . Negative_regulation EPHB2 GRAP2 9442025 482978 [ERK] activation is strongly *enhanced* by overexpression of and mitogen activated protein kinase kinase 6 ( MKK6 ) but is blocked by dominant negative kinase versions of p38 and MKK6 or the specific p38 inhibitor SB203580 . Negative_regulation EPHB2 GRAP2 9804610 544331 Anisomycin caused activation and [ERK] *inhibition* quantitatively similar to those produced by phenylephrine . Negative_regulation EPHB2 GRAP2 9804610 544346 We conclude that there is a previously unrecognized interaction between ERK and p38 MAPK , in which activation of *causes* inhibition of [ERK] ; Negative_regulation EPHB2 GRAP2 9822700 548869 Moreover , whereas inhibition of ERK had no effect on p38 activity , inhibition consistently *increased* MHV-3 induced [ERK] activity . Negative_regulation EPHB2 GRB2 10329689 613779 Expression of a mutant with a deletion of the amino-terminal Src homology 3 domain or the carboxyl-terminal tail of Sos strongly *reduced* Pyk2 induced [ERK] activation , with no apparent effect on JNK activity . Negative_regulation EPHB2 GRB2 10329689 613783 with a deleted carboxyl-terminal Src homology 3 domain partially *blocked* Pyk2 induced [ERK] and JNK pathways , whereas expression of dominant interfering mutants of p130Cas or Crk specifically inhibited JNK but not ERK activation by Pyk2 . Negative_regulation EPHB2 GRB2 8524249 335112 In contrast to results with Abl , [Erk] activation by EGF was strongly *inhibited* only by mutants ; Negative_regulation EPHB2 GRIN2A 15924861 1414112 Differential *roles* of and NR2B containing NMDA receptors in [Ras-ERK] signaling and AMPA receptor trafficking . Negative_regulation EPHB2 GRK5 15671181 1369749 Consistent with these findings , beta-arrestin mediated [ERK] activation is *enhanced* by overexpression of and 6 , and reciprocally diminished by GRK 2 and 3 . Negative_regulation EPHB2 GRK6 22509025 2589542 Conversely , ß-arrestin mediated [ERK] signaling is *enhanced* by overexpression of and diminished by GRK2 . Negative_regulation EPHB2 GSK3A 17855351 1818102 Knockdown of GSK-3alpha increased ERK phosphorylation , an effect that was inhibited by PD98059 , rottlerin , and protein kinase Cepsilon ( PKCepsilon ) inhibitor peptide , suggesting that *inhibits* [ERK] through PKC-MEK dependent mechanisms . Negative_regulation EPHB2 GSK3B 17182785 1662662 Specifically , inhibition of *led* to increased [ERK] phosphorylation , and inhibition of MEK completely blocked the effects of GSK-3beta inhibition on dendrite initiation and growth . Negative_regulation EPHB2 GSK3B 17855351 1818100 Adenovirus mediated overexpression of GSK-3alpha , but not , *inhibited* [ERK] in cultured cardiac myocytes . Negative_regulation EPHB2 HBEGF 16737974 1585289 [ERK] phosphorylation was *attenuated* by 1 ) neutralizing EGFR antibodies and the EGFR kinase inhibitor , AG1478 , 2 ) neutralizing , but not amphiregulin , antibodies , heparin , or CM197 , and 3 ) pharmacological inhibitors of matrix degrading metalloproteinases or TACE small interfering RNA . Negative_regulation EPHB2 HEPACAM 24811146 2939834 Meanwhile , prevented the androgen receptor translocation from the cytoplasm to the nucleus and *down-regulated* the [MAPK/ERK] signaling . Negative_regulation EPHB2 HGF 11071904 748653 Sequential activation of [ERK] and *repression* of JNK by growth factor in madin-darby canine kidney epithelial cells . Negative_regulation EPHB2 HGF 12595276 1084981 When PDGF and HGF were simultaneously added , *inhibited* the prolonged activation of [ERK] , which suggests that early inactivation of PDGF induced ERK may be involved in the inhibitory effect of HGF on mesangial cell proliferation . Negative_regulation EPHB2 HGF 12637990 1068682 Interestingly , VEGF mediated phosphorylation of [ERK] was significantly *attenuated* by . Negative_regulation EPHB2 HGF 24126105 2867917 Depletion of Gab1 , using siRNA , decreased the [ERK] and Akt activation , cyclin D1 expression , and DNA synthesis in *response* to both EGF and . Negative_regulation EPHB2 HRAS 10666033 665341 Conditional overexpression *inhibited* urea- and NaCl-inducible [ERK] phosphorylation by 40-50 % , but only at 15 min , and not 5 min , of treatment . Negative_regulation EPHB2 HRAS 10727428 677892 Dominant negative *inhibited* both [ERK] activation and ANF up-regulation by Ang II , whereas constitutively active forms of Ras and MEK were sufficient to activate the ANF promoter . Negative_regulation EPHB2 HRAS 11018025 752774 Expression of a dominant negative mutant of also did not significantly *impair* calcium induced [ERK] activation , indicating that calcium mediated ERK activation does not require active Ras . Negative_regulation EPHB2 HRAS 11278310 810919 In contrast , inhibition of or Src *had* no effect on the sustained [ERK] activity , which was critically dependent on phosphatidylinositol 3-kinase . Negative_regulation EPHB2 HRAS 11418608 843252 VPA induced activation of [ERK] was *blocked* by the mitogen activated protein kinase/ERK kinase inhibitor PD098059 and dominant negative and Raf mutants but not by dominant negative stress activated protein kinase/ERK kinase and mitogen activated protein kinase kinase 6 mutants . Negative_regulation EPHB2 HRAS 11424087 831233 Although dominant negative mutant of substantially *inhibited* the basal activities of [ERK] and p38 MAPK , it exhibited marginal effect on VEGF induced activation of ERK and p38 MAPK in HUVECs and HAECs . Negative_regulation EPHB2 HRAS 11701752 878757 An expression of dominant inhibitory *inhibited* nicotine induced [ERK] phosphorylation . Negative_regulation EPHB2 HRAS 11709720 879941 Overexpression of galectin-1 increased membrane associated Ras , Ras-GTP , and active [ERK] resulting in cell transformation , which was *blocked* by dominant negative . Negative_regulation EPHB2 HRAS 11874466 918769 Further evidence for differential regulation of RAS and ERK is provided by the observations that TPO , which activates RAS but not protein kinase C , does not activate [ERK] , and that the inhibitor of SRC kinases PP1 *inhibits* activation of but not ERK2 in response to thrombin . Negative_regulation EPHB2 HRAS 11960991 953702 By contrast inhibition of , by inhibition of farnesyl transferase ( Ftase-1 ) or dominant negative ( N17 ) -Ras , significantly inhibited both E ( 2 ) - and TGF alpha induced [Erk] *activation* . Negative_regulation EPHB2 HRAS 12595244 1061189 Dominant negative , but not Rap , *blocks* NTF induced [ERK] activation and VR1 upregulation . Negative_regulation EPHB2 HRAS 14660603 1202124 However , when COS-1 cells were transfected with Ras complexed to CD8 , plasma membrane localization of was unaffected by AFC , yet EGF stimulated [Erk] activation was *inhibited* by AFC . Negative_regulation EPHB2 HRAS 14680820 1179141 Unexpectedly , dominant negative *blocked* activation of Ras and [ERK] in response to IL-2R engagement but not TCR/CD3 ligation . Negative_regulation EPHB2 HRAS 15070811 1265696 Specific IL-1 receptor antagonism and selective [MAPK/ERK] kinase or upstream *inhibition* prevented these increases , whereas PKC inhibition did not . Negative_regulation EPHB2 HRAS 15516985 1343126 was also constitutively active in patient NK cells , and exposure of cells to the Ras inhibitor FTI2153 or to dominant-negative-Ras *resulted* not only in [ERK] inhibition but also in enhanced apoptosis in both the presence and absence of anti-Fas . Negative_regulation EPHB2 HRAS 15855657 1439576 Expression of a dominant-inhibitory mutant of *reduced* complement mediated activation of [ERK] , but activation was not affected significantly by downregulation of protein kinase C. Complement induced ERK activation resulted in phosphorylation of cytosolic phospholipase A2 and was , in part , responsible for phosphorylation of mitogen activated protein kinase associated protein kinase-2 , but did not induce phosphorylation of the transcription factor , Elk-1 . Negative_regulation EPHB2 HRAS 17045653 1666537 In the present study , we investigated the *role* of in FLG- and LPS mediated signaling in [ERK] activation in chicken heterophils . Negative_regulation EPHB2 HRAS 18771726 1980326 We demonstrated here , that PTPIP51 could regulate ERK activity on Raf level , since MEK inhibitor and dominant negative Raf-1 but not could *inhibit* the [ERK] activation induced by PTPIP51 . Negative_regulation EPHB2 HRAS 21719512 2483876 Dominant negative or K-Ras reduced accumulation of H-Ras and K-Ras in focal adhesions induced by IL-1 and also *blocked* [ERK] activation and focal adhesion maturation . Negative_regulation EPHB2 HRAS 22371971 2561697 Inhibition of calcineurin further reduced the phosphorylation of [ERK] and AKT ( at thr 308 ) and *inhibited* the activation of , but inhibitors of MAPK or PI3K signaling did not affect the circadian rhythm of calcineurin activity . Negative_regulation EPHB2 HRAS 22425622 2612639 DGKa knockdown impaired MEK and [ERK] phosphorylation , but did not *inhibit* activation in HCC cells . Negative_regulation EPHB2 HRAS 7862167 296214 Previous studies have indicated that activation of ERks in this cell line is dependent upon Ras since a dominant negative ( Asn-17 ) *blocks* [ERK] activation by insulin . Negative_regulation EPHB2 HRAS 8626428 355718 However , expression of dominant interfering ( N17Ras ) *inhibited* the insulin- but not osmotic shock stimulated phosphorylation of [ERK] and SOS . Negative_regulation EPHB2 HRAS 8758915 377893 [ERK] activation by BHTOOH was *inhibited* by suramin , and by expression of dominant negative in PC12 cells , suggesting overlap between the pathways for BHTOOH and growth factor signaling . Negative_regulation EPHB2 HRAS 8995450 409602 Expression of the mutant ( alpha ) i2 ( G203 ) , antisense G ( alpha ) i2 and a dominant negative ( N17Ras ) *prevented* shear dependent activation of [HA-ERK] , while that of ( alpha ) i2 ( G204 ) and antisense ( alpha ) i3 did not . Negative_regulation EPHB2 HRAS 9171350 433391 While the stimulation of [Erk] by alpha6beta4 was *suppressed* by dominant negative Shc , and RhoA , the activation of Jnk was inhibited by dominant negative Ras and Rac1 and by the phosphoinositide 3-kinase inhibitor Wortmannin . Negative_regulation EPHB2 HRAS 9432981 482448 Transient expression of the dominant negative significantly *suppressed* [ERK] activation by full-length CD40 , but marginally suppressed ERK activation by CD40 delta 246 , compatible with the possibility that TRAF6 is a major transducer of ERK activation by CD40 delta 246 , whose activity is mediated by a Ras independent pathway . Negative_regulation EPHB2 HRAS 9564040 500700 Induction of ( N17 ) *blocked* EGF- but not Ang II- or phorbol ester ( TPA ) -dependent [ERK] activation . Negative_regulation EPHB2 HRAS 9593727 505782 Dominant negative mutants of ( but not Rac or Cdc42 ) specifically *inhibited* [ERK] activation by v-Fps and Myr-Fes , demonstrating that ERK activation occurs exclusively downstream of Ras . Negative_regulation EPHB2 HRAS 9763608 537161 Here we demonstrate that the BCR induced [ERK] activation is *reduced* by loss of Grb2 or expression of a dominant negative form of , RasN17 , whereas this response is not affected by loss of Shc . Negative_regulation EPHB2 HRG 9712155 527224 A MEK specific inhibitor , PD98059 , which inhibited activation of [ERK] in *response* to , completely blocked HRG induced differentiation and reversed cell growth arrest . Negative_regulation EPHB2 HSP90AA1 12223143 987668 HRT , VCR , and Vp16 could inhibit cell proliferation ( 0.28 % 0.08 % , 0.25 % 0.16 % , 0.24 % 0.11 % ) , induce apoptosis ( 21.12 % , 28.83 % , 12.30 % ) , *inhibit* activity , and down-regulate the protein expression of phosphorylated [ERK] . Negative_regulation EPHB2 HSP90AA1 12674761 1030444 The results showed that HRT , VCR and Vp16 could inhibit cell proliferation , induce apoptosis , *inhibit* activity and down-regulate the protein expression of phosphorylated [ERK] . Negative_regulation EPHB2 HSP90AA1 16844778 1592157 inhibition transiently activates Src kinase and *promotes* Src dependent Akt and [Erk] activation . Negative_regulation EPHB2 HSPD1 16985260 1673931 In the mitochondria depleted cells , overexpression of with adenoviral vector increased the abundance of IGF-I receptor , enhanced IGF-I activated receptor phosphorylation , and *augmented* IGF-I activation of Akt and [ERK] . Negative_regulation EPHB2 HSPG2 14676843 1202514 Inhibition of *resulted* in complete inhibition of [ERK] , while having no affect on p38 activity . Negative_regulation EPHB2 HSPG2 18367332 1892595 These results demonstrate that PSs regulate Erk activity through a PKCalpha dependent pathway and that disruption of signaling in the absence of both PS1 and PS2 *results* in lower downstream activation of [Erk] . Negative_regulation EPHB2 HSPG2 24696141 2938758 Inhibition of PAC1 receptor stimulated signaling by bisindoylmaleimide I also attenuated ERK phosphorylation , and direct PKC activation with phorbol ester *increased* [ERK] phosphorylation in a temperature dependent manner . Negative_regulation EPHB2 HTR2B 20870034 2343037 In conclusion , KMUP-1 inhibits MCT induced PA proliferation by binding to 5-HT(2A) , 5-HT(2B) and 5-HT(2C) receptors , increasing endothelial receptor expression and NO release and *inhibiting* 5-HTT/RhoA/ROCK expression and [AKT/ERK] phosphorylation . Negative_regulation EPHB2 ICAM1 19823174 2187267 Sulfur dioxide donor significantly downregulated Raf-1 , mitogen activated protein kinase kinase-1 ( MEK-1 ) and [p-ERK/ERK] , and *inhibited* pulmonary vascular smooth muscle cell proliferation , collagen remodeling and pulmonary vascular endothelial cell nuclear factor-kappaB (NF-kappaB) , and ( ICAM-1 ) expressions . Negative_regulation EPHB2 ICOS 12594849 1061081 The association of phosphoinositide 3-kinase (PI-3K) to H4/ICOS was enhanced by

cross linking , and PI-3K inhibitors *inhibited* [ERK] and JNK activation and IL-4/IL-10 secretion , but not p38 MAP kinase or ZAP-70 activation . Negative_regulation EPHB2 IFI27 19158484 2027268 Inhibition of ( Kip1 ) gene expression by PDGF *required* protein synthesis and histone deacetylase activity but not Akt or [ERK] activity . Negative_regulation EPHB2 IFITM1 19499152 2091878 These results revealed that the interaction between and CAV-1 could *enhance* the inhibitory effect of CAV-1 on [ERK] activation . Negative_regulation EPHB2 IFNA2 10945503 721556 *reduces* phosphorylation and activity of MEK and [ERK] through a Ras/Raf independent mechanism . Negative_regulation EPHB2 IFNG 17127048 1732206 In conclusion , ( 1 ) p38MAPK-pathway rather than ERK-pathway may play a more basic role in the regulation of the increased T-bet expression in asthma , and ( 2 ) [ERK-] and p38MAPK-activation modulate IFNgamma expression independently of T-bet and this regulatory role of ERK-1/-2 on release is *impaired* in asthma . Negative_regulation EPHB2 IFNG 18174382 1889909 Chemical disruption of lipid rafts inhibited [ERK] signaling in response to costimulation and significantly *inhibited* production . Negative_regulation EPHB2 IGF1 24003223 2851348 Eventually , GAREM2 regulates [Erk] activation in the *presence* of EGF or . Negative_regulation EPHB2 IGF1R 22441800 2612826 and IGF-2R activation each *resulted* in [ERK] signaling , but IGF-2R activation alone induced CaMKII signaling , resulting in hypertrophy of cardiomyocytes in the late gestation sheep fetus . Negative_regulation EPHB2 IGF2R 22441800 2612827 IGF-1R and activation each *resulted* in [ERK] signaling , but IGF-2R activation alone induced CaMKII signaling , resulting in hypertrophy of cardiomyocytes in the late gestation sheep fetus . Negative_regulation EPHB2 IGFBP7 18267069 1865709 Expression of BRAFV600E in primary cells leads to synthesis and secretion of , which acts through autocrine/paracrine pathways to *inhibit* [BRAF-MEK-ERK] signaling and induce senescence and apoptosis . Negative_regulation EPHB2 IGFBP7 22383111 2587430 could also *inhibit* the phosphorylation of [ERK] and the expression of PCNA , MMP2 and MMP9 in HTR-8 and JEG-3 cells . Negative_regulation EPHB2 IKBKB 11149911 780439 TNF-alpha mediated activation of [MEK/ERK] and EGR-1 can be *blocked* by adenoviral expression of a dominant negative mutant of , whereas the VEGF signaling pathway is unaffected . Negative_regulation EPHB2 IKBKB 14604964 1209544 The antigen induced tyrosine phosphorylation of FcepsilonRI , Syk , phospholipase C-gamma (PLC-gamma) , activation of c-Jun N-terminal kinase (JNK) , extracellular signal regulated kinase ( [ERK] ) , *inhibitor* of nuclear factor kappaB kinase ( ) , and Ca++ influx were all suppressed in the cells overexpressing Cbl-b in the lipid raft . Negative_regulation EPHB2 IKBKB 22733995 2639212 Unexpectedly , TPL-2 promoted soluble TNF production independently of *induced* p105 phosphorylation and its ability to activate [ERK] , which has important implications for the development of anti-inflammatory drugs targeting TPL-2 . Negative_regulation EPHB2 IKBKG 14604964 1209545 The antigen induced tyrosine phosphorylation of FcepsilonRI , Syk , phospholipase C-gamma (PLC-gamma) , activation of c-Jun N-terminal kinase (JNK) , extracellular signal regulated kinase ( [ERK] ) , *inhibitor* of nuclear factor kappaB kinase ( ) , and Ca++ influx were all suppressed in the cells overexpressing Cbl-b in the lipid raft . Negative_regulation EPHB2 IKBKG 22733995 2639213 Unexpectedly , TPL-2 promoted soluble TNF production independently of *induced* p105 phosphorylation and its ability to activate [ERK] , which has important implications for the development of anti-inflammatory drugs targeting TPL-2 . Negative_regulation EPHB2 IL10 12112010 963584 Thus , we speculate that during inflammatory conditions in vivo macrophage p38 may regulate JNK and [ERK] activity and *inhibit* expression . Negative_regulation EPHB2 IL10 14764680 1207225 significantly *inhibited* CD40 induced activation of the [ERK] , p38 MAPK , and NF-kappaB pathways ; Negative_regulation EPHB2 IL10 22579699 2614251 Additionally , CA treatment induced [ERK] and JNK phosphorylation , and unexpectedly , elevated levels of and TGF-ß were *inhibited* by the addition of an ERK-specific inhibitor . Negative_regulation EPHB2 IL17A 21145111 2373138 In accordance with the enhanced expression of IL-23 p19 , stimulation *resulted* in rapid activation of Akt , p38 mitogen activated protein kinase (MAPK) , extracellular signal regulated kinase ( [ERK] ) 1/2 , c-Jun-N-terminal kinase (JNK) , nuclear factor-kappaB ( NF-?B ) , and activator protein-1 (AP-1) in hPDLFs . Negative_regulation EPHB2 IL17D 20112358 2206300 inhibited human osteoclastogenesis , suppressed the induction of NFATc1 , down-regulated the expression of RANK and triggering receptor expressed on myeloid cells 2 ( TREM-2 ) , and *inhibited* RANKL mediated activation of [ERK] , p38 , and NF-kappaB in osteoclast precursors . Negative_regulation EPHB2 IL17RD 15239952 1269921 Thus , binds to activated forms of MEK , inhibits the dissociation of the MEK-ERK complex , and *blocks* nuclear translocation of activated [ERK] . Negative_regulation EPHB2 IL17RD 15239952 1269925 Downregulation of endogenous by hSef siRNA *enhances* the stimulus induced [ERK] nuclear translocation and the activity of Elk-1 . Negative_regulation EPHB2 IL17RD 21663947 2459740 We found that the hSef expression was positively regulated by FGF2 induced MAPK/ERK signaling and inversely , expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation EPHB2 IL1A 23680829 2819349 These results suggest that *induces* an imbalance between anabolic and catabolic events in AF cells , [ERK] inhibition could provide some protection against the adverse effects of IL-1 . Negative_regulation EPHB2 IL1B 14612947 1163444 Finally , *induced* proliferation of Balb 3T3 cells and inhibition of [Erk] and Akt signalings or their upstream signaling molecules , Src kinase and PKC by their inhibitors strongly inhibited IL-1beta dependent cell proliferation . Negative_regulation EPHB2 IL2 14680820 1179142 Unexpectedly , dominant negative Ras17N blocked activation of Ras and [ERK] in *response* to engagement but not TCR/CD3 ligation . Negative_regulation EPHB2 IL2 22932814 2740233 Morphine pretreatment enhanced [ERK] phosphorylation , but *inhibited* I?Ba phosphorylation and gene expression in activated T cells . Negative_regulation EPHB2 IL21 24574581 2886286 Western blot analysis showed that clearly *inhibited* [ERK] and I?Ba phosphorylation and NF-?B translocation in LPS stimulated macrophages , but it increased STAT3 phosphorylation . Negative_regulation EPHB2 IL3 12270548 990765 Tyrosine phosphorylation of [ERK] was *detected* after stimulation with IL-3 or MSP , whereas treatment with U0126 specifically inhibited or MSP induced ERK phosphorylation but not tyrosine phosphorylation of betac . Negative_regulation EPHB2 IL3 9593267 505703 In contrast , stimulation of the receptor in AML193 cells *resulted* in a transient [Erk] activation peaking at 5 min and returning to base levels after 15 min . Negative_regulation EPHB2 IL32 12637990 1068681 Interestingly , VEGF mediated phosphorylation of [ERK] was significantly *attenuated* by . Negative_regulation EPHB2 IL4 9918806 559200 Our results show that modestly *inhibited* JNK/SAPK and [ERK] activation by TNF-alpha . Negative_regulation EPHB2 IL8 17704189 1822342 In addition , overexpression of the MEK1 -- > ERK pathway significantly increased expression , and a small interfering RNA to the NADPH oxidase *inhibited* [ERK-] and TNF-alpha induced chemokine expression . Negative_regulation EPHB2 INS 11918738 925924 Moreover , also *suppressed* [ERK] activation during apoptosis . Negative_regulation EPHB2 INS 15520010 1359763 These findings provide a new mechanism for *induced* desensitization of [ERK] activation by Galphai coupled receptors . Negative_regulation EPHB2 INS 16988072 1617881 However , did not block the GH-induced activation of STAT5 , and GH did not *block* the INS induction of [ERK] activity or of increased glucose uptake . Negative_regulation EPHB2 INS 17149366 1661615 Inhibition of EGFR activation by AG1478 or the MMP inhibitor , GM6001 , *reduced* phosphorylation of insulin induced [ERK] in the presence of and delayed wound closure . Negative_regulation EPHB2 IQSEC1 22701712 2615852 Ectopic expression GEP100 siRNA , , or Arf6-T27N *suppressed* EGF induced [ERK] and Rac1 activity . Negative_regulation EPHB2 IRAK3 17379480 1748355 Furthermore , using bone marrow derived macrophages ( BMDM ) from wild type , IRAK1 ( -/- ) , and IRAK-M ( -/- ) mice , we have herein demonstrated that selectively *attenuates* bacterial lipopeptide Pam ( 3 ) CSK ( 4 ) -induced p38 activation , but not [ERK] or JNK . Negative_regulation EPHB2 IRS1 19762915 2158779 In normal human chondrocytes , tBHP triggered strong IRS-1 ( Ser-312 and Ser-616 ) and [ERK] phosphorylation and *inhibited* IGF-I induced ( Tyr-612 ) and Akt phosphorylation . Negative_regulation EPHB2 ITGB1BP1 20616313 2309991 *inhibits* Rho kinase activity and [ERK] ( extracellular signal regulated kinase ) phosphorylation and induces expression of the cell cycle inhibitors p21 and p27 , leading to less endothelial proliferation . Negative_regulation EPHB2 JAK1 16291589 1525987 TCCM treatment activated p38 mitogen activated protein kinase (MAPK) and but *inhibited* [extracellular regulated kinase (ERK)] . Negative_regulation EPHB2 JAK2 14551204 1185949 Previous work has shown that inhibition of Jak2 via the pharmacological compound AG490 blocks the angiotensin II (Ang II) dependent activation of ERK2 , thereby suggesting an essential *role* of in [ERK] activation . Negative_regulation EPHB2 JAK2 14551204 1185955 However , recent studies have thrown into question the specificity of AG490 and therefore the *role* of in [ERK] activation . Negative_regulation EPHB2 JAK2 16291589 1525988 TCCM treatment activated p38 mitogen activated protein kinase (MAPK) and but *inhibited* [extracellular regulated kinase (ERK)] . Negative_regulation EPHB2 JAK2 16788692 1599454 Inhibition of or STAT3 *lead* to increased [ERK] activation and survival of TKPTS cells during severe oxidative stress . Negative_regulation EPHB2 JAK2 21490369 2448484 GH-induced [ERK] *activation* was completely blocked by the ERK pathway inhibitor , U0126 , and the inhibitor , 1,2,3,4,5,6-hexabromocyclohexane ( Hex ) , and was partially blocked by the PI3K inhibitor LY294002 . Negative_regulation EPHB2 JAK3 16291589 1525989 TCCM treatment activated p38 mitogen activated protein kinase (MAPK) and but *inhibited* [extracellular regulated kinase (ERK)] . Negative_regulation EPHB2 JUN 10585423 571333 This AP-1 activation was completely blocked by PD 098059 , a specific mitogen activated protein [kinase/ERK] kinase *inhibitor* , as well as by a dominant negative JNK or a dominant negative , indicating that the AP-1 activation induced by 1,25 ( OH ) ( 2 ) D ( 3 ) was mediated by ERK and JNK . Negative_regulation EPHB2 JUN 11695993 877176 In contrast with 18 : 1 ( n-9 ) NAE and anandamide , the cannabinoid receptor agonist WIN 55,212-2 did not stimulate activity and *inhibited* [ERK] phosphorylation . Negative_regulation EPHB2 JUN 21170925 2521311 In CT-26 cells , the extracellular signal regulated kinase ( [ERK] ) inhibitor inhibited cell proliferation , invasion and MMP-9 expression , and the inhibitor *suppressed* the expression of both MMPs , as well as cell proliferation and cell invasion . Negative_regulation EPHB2 JUN 21211365 2359500 Transfected recombinant elafin reduced MUC5AC protein ( 0.71 ± 0.04 ) mg/L and mRNA level ( 0.81 ± 0.04 ) , decreased p-JNK ( 0.38 ± 0.04 ) microg/mg and [p-ERK] ( 0.31 ± 0.04 ) µg/mg production , *inhibited* activity ( 2.60 ± 0.19 ) and NF-?B activity ( 2.55 ± 0.21 ) , but increased I?Ba protein ( 0.54 ± 0.03 ) µg/mg , compared with single CSE stimulated group ( all P < 0.05 ) . Negative_regulation EPHB2 JUN 9886863 584852 Concurrent activation of and *inhibition* of [Erk] mitogen activated protein kinase activities is important for apoptosis in many cells , and we previously demonstrated that stimulation of AT2 receptors causes decreased mitogen activated protein kinase activity in neurons cultured from newborn rat hypothalamus and brain stem . Negative_regulation EPHB2 KCNH4 18463290 1910080 experiments with hBVR nuclear export signal (NES) and nuclear localization signal ( NLS ) mutants demonstrated its critical *role* in the nuclear localization of IGF stimulated [ERK] for activation . Negative_regulation EPHB2 KCNH4 18616461 1947302 Silencing of CREB or significantly *increased* [ERK] activation observed after 5 min of morphine stimulation . Negative_regulation EPHB2 KDR 15541367 1336922 stimulation did not induce ERK phosphorylation in human PKCdelta-knockdown HEK293T cells , but co-expression of rat PKCdelta-GFP *recovered* the [ERK] phosphorylation . Negative_regulation EPHB2 KIR3DL1 18292496 1872921 In CD158b expressing cells , triggering *leads* to an inhibition of the CD3 induced cell proliferation and [Erk] activation , and the receptor exhibits an activation dependent tyrosine phosphorylation and association with the Src homology 2-containing phosphatase 1 . Negative_regulation EPHB2 KL 16436388 1527834 In addition , significantly *enhanced* the ability of FGF23 to induce phosphorylation of FGF receptor substrate and [ERK] in various types of cells . Negative_regulation EPHB2 KL 23248036 2757903 Exogenous gene expression also *down-regulated* the phosphorylation levels of the IGF-1 receptor , and the downstream Akt , [ERK] , and p70S6K proteins . Negative_regulation EPHB2 KLK3 22410422 2567034 Mechanistic studies indicated that strongly suppressed NF-?B activation and *down-regulated* the phosphorylation of [ERK] and JNK , which are important signaling pathways involved in the production of TNF-a and IL-1ß , demonstrating that APS could suppress the production of TNF-a and IL-1ß by LPS stimulated macrophages by inhibiting NF-?B activation and ERK and JNK phosphorylation . Negative_regulation EPHB2 KRAS 10666033 665342 Conditional overexpression *inhibited* urea- and NaCl-inducible [ERK] phosphorylation by 40-50 % , but only at 15 min , and not 5 min , of treatment . Negative_regulation EPHB2 KRAS 10727428 677893 Dominant negative *inhibited* both [ERK] activation and ANF up-regulation by Ang II , whereas constitutively active forms of Ras and MEK were sufficient to activate the ANF promoter . Negative_regulation EPHB2 KRAS 11018025 752775 Expression of a dominant negative mutant of also did not significantly *impair* calcium induced [ERK] activation , indicating that calcium mediated ERK activation does not require active Ras . Negative_regulation EPHB2 KRAS 11278310 810920 In contrast , inhibition of or Src *had* no effect on the sustained [ERK] activity , which was critically dependent on phosphatidylinositol 3-kinase . Negative_regulation EPHB2 KRAS 11418608 843253 VPA induced activation of [ERK] was *blocked* by the mitogen activated protein kinase/ERK kinase inhibitor PD098059 and dominant negative and Raf mutants but not by dominant negative stress activated protein kinase/ERK kinase and mitogen activated protein kinase kinase 6 mutants . Negative_regulation EPHB2 KRAS 11701752 878758 An expression of dominant inhibitory *inhibited* nicotine induced [ERK] phosphorylation . Negative_regulation EPHB2 KRAS 11709720 879942 Overexpression of galectin-1 increased membrane associated Ras , Ras-GTP , and active [ERK] resulting in cell transformation , which was *blocked* by dominant negative . Negative_regulation EPHB2 KRAS 11874466 918770 Further evidence for differential regulation of RAS and ERK is provided by the observations that TPO , which activates RAS but not protein kinase C , does not activate [ERK] , and that the inhibitor of SRC kinases PP1 *inhibits* activation of but not ERK2 in response to thrombin . Negative_regulation EPHB2 KRAS 11960991 953703 By contrast inhibition of , by inhibition of farnesyl transferase ( Ftase-1 ) or dominant negative ( N17 ) -Ras , significantly inhibited both E ( 2 ) - and TGF alpha induced [Erk] *activation* . Negative_regulation EPHB2 KRAS 12595244 1061190 Dominant negative , but not Rap , *blocks* NTF induced [ERK] activation and VR1 upregulation . Negative_regulation EPHB2 KRAS 14660603 1202125 However , when COS-1 cells were transfected with Ras complexed to CD8 , plasma membrane localization of was unaffected by AFC , yet EGF stimulated [Erk] activation was *inhibited* by AFC . Negative_regulation EPHB2 KRAS 14680820 1179143 Unexpectedly , dominant negative *blocked* activation of Ras and [ERK] in response to IL-2R engagement but not TCR/CD3 ligation . Negative_regulation EPHB2 KRAS 15070811 1265697 Specific IL-1 receptor antagonism and selective [MAPK/ERK] kinase or upstream *inhibition* prevented these increases , whereas PKC inhibition did not . Negative_regulation EPHB2 KRAS 15516985 1343127 was also constitutively active in patient NK cells , and exposure of cells to the Ras inhibitor FTI2153 or to dominant-negative-Ras resulted not only in [ERK] *inhibition* but also in enhanced apoptosis in both the presence and absence of anti-Fas . Negative_regulation EPHB2 KRAS 15855657 1439577 Expression of a dominant-inhibitory mutant of *reduced* complement mediated activation of [ERK] , but activation was not affected significantly by downregulation of protein kinase C. Complement induced ERK activation resulted in phosphorylation of cytosolic phospholipase A2 and was , in part , responsible for phosphorylation of mitogen activated protein kinase associated protein kinase-2 , but did not induce phosphorylation of the transcription factor , Elk-1 . Negative_regulation EPHB2 KRAS 17045653 1666538 In the present study , we investigated the *role* of in FLG- and LPS mediated signaling in [ERK] activation in chicken heterophils . Negative_regulation EPHB2 KRAS 17192389 1724636 Comparison of wild-type and Kras ( G12D ) c-kit ( + ) lin ( -/low ) cells shows that ( G12D ) expression causes hyperproliferation in vivo and *results* in abnormal levels of phosphorylated STAT5 , [ERK] , and S6 under basal and stimulated conditions . Negative_regulation EPHB2 KRAS 18771726 1980327 We demonstrated here , that PTPIP51 could regulate ERK activity on Raf level , since MEK inhibitor and dominant negative Raf-1 but not could *inhibit* the [ERK] activation induced by PTPIP51 . Negative_regulation EPHB2 KRAS 21719512 2483877 Dominant negative H-Ras or reduced accumulation of H-Ras and K-Ras in focal adhesions induced by IL-1 and also *blocked* [ERK] activation and focal adhesion maturation . Negative_regulation EPHB2 KRAS 22142613 2530532 Cellular evaluation of 1b revealed that it alters the subcellular localization of , and also *inhibits* both Ras activation and [Erk] phosphorylation in Jurkat cells . Negative_regulation EPHB2 KRAS 22371971 2561698 Inhibition of calcineurin further reduced the phosphorylation of [ERK] and AKT ( at thr 308 ) and *inhibited* the activation of , but inhibitors of MAPK or PI3K signaling did not affect the circadian rhythm of calcineurin activity . Negative_regulation EPHB2 KRAS 22425622 2612640 DGKa knockdown impaired MEK and [ERK] phosphorylation , but did not *inhibit* activation in HCC cells . Negative_regulation EPHB2 KRAS 7862167 296215 Previous studies have indicated that activation of ERks in this cell line is dependent upon Ras since a dominant negative ( Asn-17 ) *blocks* [ERK] activation by insulin . Negative_regulation EPHB2 KRAS 8626428 355719 However , expression of dominant interfering ( N17Ras ) *inhibited* the insulin- but not osmotic shock stimulated phosphorylation of [ERK] and SOS . Negative_regulation EPHB2 KRAS 8758915 377894 [ERK] activation by BHTOOH was *inhibited* by suramin , and by expression of dominant negative in PC12 cells , suggesting overlap between the pathways for BHTOOH and growth factor signaling . Negative_regulation EPHB2 KRAS 8995450 409603 Expression of the mutant ( alpha ) i2 ( G203 ) , antisense G ( alpha ) i2 and a dominant negative ( N17Ras ) *prevented* shear dependent activation of [HA-ERK] , while that of ( alpha ) i2 ( G204 ) and antisense ( alpha ) i3 did not . Negative_regulation EPHB2 KRAS 9171350 433392 While the stimulation of [Erk] by alpha6beta4 was *suppressed* by dominant negative Shc , and RhoA , the activation of Jnk was inhibited by dominant negative Ras and Rac1 and by the phosphoinositide 3-kinase inhibitor Wortmannin . Negative_regulation EPHB2 KRAS 9564040 500701 Induction of ( N17 ) *blocked* EGF- but not Ang II- or phorbol ester ( TPA ) -dependent [ERK] activation . Negative_regulation EPHB2 KRAS 9593727 505783 Dominant negative mutants of ( but not Rac or Cdc42 ) specifically *inhibited* [ERK] activation by v-Fps and Myr-Fes , demonstrating that ERK activation occurs exclusively downstream of Ras . Negative_regulation EPHB2 KRAS 9763608 537162 Here we demonstrate that the BCR induced [ERK] activation is *reduced* by loss of Grb2 or expression of a dominant negative form of , RasN17 , whereas this response is not affected by loss of Shc . Negative_regulation EPHB2 KRIT1 20616044 2290997 strongly induces DLL4-NOTCH signaling , which promotes AKT phosphorylation but *reduces* phosphorylation of the mitogen activated protein kinase [ERK] . Negative_regulation EPHB2 KSR1 16107706 1445089 Elevated levels of expression , previously shown to enhance cell proliferation , *promote* high , sustained [ERK] activation that phosphorylates and inhibits peroxisome proliferator activated receptor gamma , inhibiting adipogenesis . Negative_regulation EPHB2 KSR1 17056543 1636590 Although the scaffold kinase suppressor of Ras (KSR)1 is required for efficient Erk activation by mitogenic stimuli , the *role* of in [ERK] activation by inflammatory and stress stimuli is unknown . Negative_regulation EPHB2 KSR1 23431403 2744410 Absence of , a scaffold protein of the ERK signaling pathway , or *inhibition* of [ERK] resulted in decreased mTORC1 activity following T cell activation . Negative_regulation EPHB2 LAT 12817019 1103574 Because TCR activates ERK via SLP-76 mediated activation of the linker of activated T cells (LAT) scaffold protein , we examined the *role* of in SDF-1alpha mediated [ERK] activation . Negative_regulation EPHB2 LCP2 9257823 448514 Overexpression of does , however , *augment* TCR stimulation of both [ERK] ( extracellular signal regulated kinase ) activity and a reporter construct driven by activating protein-1 binding sites . Negative_regulation EPHB2 LGALS1 11709720 879943 Overexpression of *increased* membrane associated Ras , Ras-GTP , and active [ERK] resulting in cell transformation , which was blocked by dominant negative Ras . Negative_regulation EPHB2 LGALS1 22266356 2559782 An examination of the effect of sialylation on epidermal growth factor receptor (EGFR) activity and downstream signaling , which are highly correlated with cell proliferation , showed that the loss of *augmented* EGF induced EGFR phosphorylation and activation of extracellular signal regulated kinase ( [ERK] ) in colon cancer cells . Negative_regulation EPHB2 LGI1 19835947 2203007 is a secreted protein , and when the culture supernatant from cells expressing FLAG- and GFP tagged proteins were applied to parental T98G cells , [ERK/MAPK1] phosphorylation and cell mobility was *suppressed* , demonstrating that the LGI1 protein acts as a suppressive agent for cell movement in this assay . Negative_regulation EPHB2 LHB 20685880 2322784 Dusp1 overexpression abolishes sustained [ERK] activation and *inhibits* promoter activity induced by high amplitude pulses . Negative_regulation EPHB2 LOX 20717927 2345716 In MIA PaCa-2 cells in culture , *attenuated* the [ERK] and AKT activities and decreased the levels of the NF-?B p65 and RelB subunits and cyclin D1 , which are activated by RAS signaling . Negative_regulation EPHB2 LPA 10688043 669952 Inhibition of EGF- and *induced* [ERK] activation with the EGF receptor inhibitor , AG1478 , or the MEK inhibitor , PD98059 , attenuated their proliferative effects . Negative_regulation EPHB2 LPA 12902401 1121132 *induced* ERK activation results in a transient translocation of the phosphorylated [ERK] to newly forming focal contact sites at the leading edge of the migrating cells . Negative_regulation EPHB2 LPA 16246039 1471353 Oxidized low-density *inhibits* insulin dependent phosphorylation of the signalling kinases [ERK] ( extracellular-signal regulated kinase ) and PKB/Akt . Negative_regulation EPHB2 LPA 21209852 2359312 also increased ERK activity and the MEK inhibitor U0126 could *block* LPA induced [ERK] activity and cell migration . Negative_regulation EPHB2 LPA 21209852 2359321 Furthermore , increased PI3K activity , and the PI3K inhibitor LY294002 *inhibited* both LPA induced [PAK1/ERK] activation and cell migration . Negative_regulation EPHB2 LRP1 21610072 2454243 The simultaneous stimulation of a receptor tyrosine kinase by its cognate ligand and of ( by lactoferrin or LDL ) *resulted* in sustained activation of [ERK] , which was redirected to the cytoplasm . Negative_regulation EPHB2 LRPAP1 12595244 1061191 Dominant negative Ras , but not , *blocks* NTF induced [ERK] activation and VR1 upregulation . Negative_regulation EPHB2 LRPAP1 18656457 1960545 Exogenous uPA administered at 4 h post H/I further stimulated [ERK] MAPK phosphorylation , which was *blocked* by . Negative_regulation EPHB2 LRPAP1 20164682 2242594 Active ERK signaling is known to block chondrogenic differentiation and we revealed induction of aggrecan expression in chondrocytes by treatment with or PD098059 , an [ERK] *inhibitor* . Negative_regulation EPHB2 LTA 19602669 2142709 Moreover , *inhibited* phosphorylation of [ERK] and JNK in osteoclast precursors stimulated with M-CSF and RANKL , concomitantly with a decreased DNA binding activity of AP-1 . Negative_regulation EPHB2 LTB 11369515 817432 LPS , fMLP , and ( 4 ) *stimulated* similar levels of [ERK] and Akt activation . Negative_regulation EPHB2 LYN 11443118 850429 Overexpression of *induced* constitutive phosphorylation of CrkL and activation of [Erk] , whereas that of a Lyn mutant lacking the tyrosine kinase domain attenuated the Epo induced phosphorylation of CrkL and activation of Erk . Negative_regulation EPHB2 LYN 24407241 2900623 In addition , a constitutively active ( LYN CA ) normalized the enhanced megakaryocyte differentiation and *repressed* [ERK] signaling in PSTPIP2 knockdown cells . Negative_regulation EPHB2 MAP2K1 11002425 734674 Interference with [ERK] *activation* by either highly specific inhibitors of or a dominant negative ras mutant profoundly impaired the ability of EWS/FLI-1 to transform NIH3T3 cells to growth in semi-solid medium . Negative_regulation EPHB2 MAP2K1 11230290 789232 VSMC migration in response to OA alone and with Ang II was also inhibited by N : -acetyl-cysteine , *inhibition* , and [ERK] antisense . Negative_regulation EPHB2 MAP2K1 11418608 843254 VPA induced activation of [ERK] was *blocked* by the mitogen activated protein kinase/ERK kinase inhibitor PD098059 and dominant negative Ras and Raf mutants but not by dominant negative stress activated protein kinase/ERK kinase and 6 mutants . Negative_regulation EPHB2 MAP2K1 11641781 872190 Overexpression of dominant negative or treatment with PD98059 abolishes MST4 *induced* [ERK] activity , whereas dominant negative Ras or c-Raf-1 mutants failed to do so , indicating MST4 activates MEK1/ERK via a Ras/Raf-1 independent pathway . Negative_regulation EPHB2 MAP2K1 11821415 922605 Conversely , enforced *activation* of [ERK] by overexpression of sensitized cells to DNA damage induced apoptosis . Negative_regulation EPHB2 MAP2K1 11834245 910354 Furthermore , ( MEK)-1-specific inhibitor , 2- ( 2-amino-3-methoxyphenyl ) -4H-1-benzopyran-4-one ( PD 98059 ) , *blocked* the lipopolysaccharide induced p44/42 [ERK] activation and PDGF production . Negative_regulation EPHB2 MAP2K1 12364324 1019033 GLP1 stimulated *activation* of [Erk] is blocked by inhibitors of , but GLP1 does not induce the activation of A-Raf , B-Raf , C-Raf , or Ras . Negative_regulation EPHB2 MAP2K1 12657694 1073277 [ERK] *activation* was blocked by inhibiting , the upstream activator of ERK . Negative_regulation EPHB2 MAP2K1 12694865 1080921 U0126 , at concentrations consistent with inhibition of the isolated enzyme , *inhibited* [ERK] phosphorylation , and therefore activation , in response to each agonist . Negative_regulation EPHB2 MAP2K1 12738796 1107256 Surprisingly , this induction of phosphorylation does not *result* in [ERK] activation in vivo . Negative_regulation EPHB2 MAP2K1 14581482 1186913 Either PD98059 or U0126 , selective inhibitors of MEK , or overexpression of a dominant negative inhibited interleukin-1beta- *induced* [ERK] activation and the expression of iNOS and COX-2 but had essentially no effect on the expression of VCAM-1 and Mn-SOD . Negative_regulation EPHB2 MAP2K1 14982949 1250925 Constitutively active ( MEK ) induced MIP-1alpha , and Ras dominant negative ( DN ) *inhibited* IC-induced [ERK] phosphorylation and MIP-1alpha production . Negative_regulation EPHB2 MAP2K1 15016380 1220837 Conditional expression of a dominant negative form of in the postnatal murine forebrain *inhibited* [ERK] activation and caused selective deficits in hippocampal memory retention and the translation dependent , transcription independent phase of hippocampal L-LTP . Negative_regulation EPHB2 MAP2K1 15177934 1255130 The effects of NT on [EGFR/ERK/Akt] activation and DNA synthesis were *attenuated* by PLC-inhibitor ( U73122 ) , PKC-inhibitors ( bisindolylmaleimide , staurosporine , rottlerin ) , inhibitor ( U0126 ) and PI3 kinase inhibitors ( wortmannin , LY 294002 ) . Negative_regulation EPHB2 MAP2K1 15284289 1277887 In contrast , a mitogen activated protein (MAP) kinase/extracellular signal regulated kinase ( ERK ) kinase ( ) [/ERK] *inhibitor* , PD98059 , completely abrogated the effect of high glucose . Negative_regulation EPHB2 MAP2K1 15361836 1303927 or PI3K inhibitors *suppressed* [ERK] or Akt activation , respectively , and induced apoptosis in the v-ErbB : ER-responsive cells . Negative_regulation EPHB2 MAP2K1 15525763 1329489 Perturbation of STAT signaling by a STAT inhibitor peptide or a dominant negative STAT3 mutant causes enhanced production of rod photoreceptors in the absence of exogenous cytokines , whereas inhibiting [ERK] *activation* by a ( mitogen activated protein kinase kinase ) -specific inhibitor has no effect on rod photoreceptor differentiation in vitro . Negative_regulation EPHB2 MAP2K1 16237176 1470791 Consistent with a presynaptic function for endogenous H-ras/extracellular signal regulated kinase ( ERK ) signaling , we observed that , under normal physiologic conditions in wild-type mice , hippocampus dependent learning stimulated the ERK dependent phosphorylation of synapsin I , and ( MAP kinase kinase ) [/ERK] *inhibition* selectively decreased the frequency of miniature EPSCs . Negative_regulation EPHB2 MAP2K1 17045653 1666564 The classic Ras mediated pathway of ERK1/2 activation by LPS was confirmed when the specific Raf-1 inhibitor , GW 5074 , and the inhibitor , U0126 , both reduced [ERK] *activation* by 51-60 % . Negative_regulation EPHB2 MAP2K1 17283256 1698238 In addition , only the alpha1A-AR activated [ERK] in alpha1ABKO myocytes , and expression of a dominant negative completely *blocked* alpha1A survival signaling in alpha1ABKO myocytes . Negative_regulation EPHB2 MAP2K1 19219045 2044447 Thus , in disagreement with the current perception of the pathway , the *role* of and Mek2 in growth factor induced [Erk] phosphorylation is not interchangeable . Negative_regulation EPHB2 MAP2K1 19703440 2158071 Furthermore , [ERK] *activation* and angiogenic sprouting in response to NMB are significantly blocked by the inhibitor . Negative_regulation EPHB2 MAP2K1 20526801 2320132 Furthermore , we also demonstrate that either chemical inhibition of ( U0126 ) or stable downregulation of PDGFRß by shRNA similarly *results* in the loss of PDGF induced [ERK] phosphorylation and abolishes Rac1/Pak1 activation and cell migration in response to PDGF . Negative_regulation EPHB2 MAP2K1 20810616 2341718 We found that nanomolar concentrations of Sorafenib reduced the basal activity of [ERK] , *inhibited* cAMP dependent activation of B-Raf and signaling , and caused a concentration dependent inhibition of cell proliferation induced by cAMP , epidermal growth factor , or the combination of the two agonists . Negative_regulation EPHB2 MAP2K1 20851880 2342783 [Erk] *activation* by overexpression of constitutively active increased Runx2 transcriptional activity , whereas U0126 , an inhibitor of MEK1/2 , suppressed basal Runx2 transcriptional activity and BMP induced Runx2 acetylation and stabilization . Negative_regulation EPHB2 MAP2K1 21088259 2389764 These cells displayed high levels of [ERK] activation , that is , at least in part , independent of the conventional RAF/MEK/ERK pathway , as MEK activation was low and inhibition of did not significantly *block* activation of ERK . Negative_regulation EPHB2 MAP2K1 21166955 2378668 Thus , it is suggested that the anti-angiogenic effect of HA1077 may be due to the combination of ROCK inhibition and ( MEK ) [/ERK] pathway *inhibition* . Negative_regulation EPHB2 MAP2K1 22056560 2513933 We found that [Erk] *activation* by overexpression of constitutively active increased the mRNA and protein levels of Osterix and enhanced the transcriptional activity of Osterix , whereas U0126 , an inhibitor of MEK , suppressed the protein levels of Osterix and the transcriptional activity . Negative_regulation EPHB2 MAP2K1 22915752 2697494 Overexpression of an active form of *resulted* in [ERK] activation and downregulation of BRCA1 , whereas the MEK inhibitor AZD6244 increased BRCA1/2 expression and reversed the effects of MEK1 . Negative_regulation EPHB2 MAP2K1 23524336 2777291 A lack of or ability to accumulate tMEK *resulted* in the absence of the feedback inhibition of [ERK] and p90RSK activations . Negative_regulation EPHB2 MAP2K1 24265154 2898247 The continued MAPK signaling based resistance identified in these patients suggests that alternative dosing of current agents , more potent inhibitors , and/or *inhibition* of the downstream kinase [ERK] may be needed for durable control of BRAF-mutant melanoma . Negative_regulation EPHB2 MAP2K1 8552085 347129 Expression of a dominant interfering mutant , in which lysine 97 was replaced with arginine ( MEK/K97R ) , *resulted* in an inhibition of insulin stimulated SOS and [ERK] phosphorylation , whereas expression of a constitutively active MEK mutant , in which serines 218 and 222 were replaced with glutamic acid ( MEK/EE ) , induced basal phosphorylation of both SOS and ERK . Negative_regulation EPHB2 MAP2K1 9442025 482979 [ERK] activation is strongly *enhanced* by overexpression of p38 and 6 ( MKK6 ) but is blocked by dominant negative kinase versions of p38 and MKK6 or the specific p38 inhibitor SB203580 . Negative_regulation EPHB2 MAP2K1 9658404 517127 We further demonstrate that 5-HT1 agonists inactivate [ERK] by dephosphorylation , even in the *presence* of constitutively activated . Negative_regulation EPHB2 MAP2K1 9790922 542466 The peptide response was not inhibited by the inhibitor ( PD098059 ) and did not *stimulate* [Erk] phosphorylation . Negative_regulation EPHB2 MAP2K2 11230290 789233 VSMC migration in response to OA alone and with Ang II was also inhibited by N : -acetyl-cysteine , *inhibition* , and [ERK] antisense . Negative_regulation EPHB2 MAP2K2 11418608 843255 VPA induced activation of [ERK] was *blocked* by the mitogen activated protein kinase/ERK kinase inhibitor PD098059 and dominant negative Ras and Raf mutants but not by dominant negative stress activated protein kinase/ERK kinase and 6 mutants . Negative_regulation EPHB2 MAP2K2 11834245 910355 Furthermore , ( MEK)-1-specific inhibitor , 2- ( 2-amino-3-methoxyphenyl ) -4H-1-benzopyran-4-one ( PD 98059 ) , *blocked* the lipopolysaccharide induced p44/42 [ERK] activation and PDGF production . Negative_regulation EPHB2 MAP2K2 12364324 1019034 GLP1 stimulated *activation* of [Erk] is blocked by inhibitors of , but GLP1 does not induce the activation of A-Raf , B-Raf , C-Raf , or Ras . Negative_regulation EPHB2 MAP2K2 12657694 1073278 [ERK] *activation* was blocked by inhibiting , the upstream activator of ERK . Negative_regulation EPHB2 MAP2K2 12694865 1080922 U0126 , at concentrations consistent with inhibition of the isolated enzyme , *inhibited* [ERK] phosphorylation , and therefore activation , in response to each agonist . Negative_regulation EPHB2 MAP2K2 12738796 1107257 Surprisingly , this induction of phosphorylation does not *result* in [ERK] activation in vivo . Negative_regulation EPHB2 MAP2K2 14581482 1186914 Either PD98059 or U0126 , selective inhibitors of , or overexpression of a dominant negative MEK-1 inhibited interleukin-1beta- *induced* [ERK] activation and the expression of iNOS and COX-2 but had essentially no effect on the expression of VCAM-1 and Mn-SOD . Negative_regulation EPHB2 MAP2K2 14982949 1250926 Constitutively active ( MEK ) induced MIP-1alpha , and Ras dominant negative ( DN ) *inhibited* IC-induced [ERK] phosphorylation and MIP-1alpha production . Negative_regulation EPHB2 MAP2K2 15177934 1255131 The effects of NT on [EGFR/ERK/Akt] activation and DNA synthesis were *attenuated* by PLC-inhibitor ( U73122 ) , PKC-inhibitors ( bisindolylmaleimide , staurosporine , rottlerin ) , inhibitor ( U0126 ) and PI3 kinase inhibitors ( wortmannin , LY 294002 ) . Negative_regulation EPHB2 MAP2K2 15284289 1277888 In contrast , a mitogen activated protein (MAP) kinase/extracellular signal regulated kinase ( [ERK] ) kinase ( ) /ERK *inhibitor* , PD98059 , completely abrogated the effect of high glucose . Negative_regulation EPHB2 MAP2K2 15361836 1303928 or PI3K inhibitors *suppressed* [ERK] or Akt activation , respectively , and induced apoptosis in the v-ErbB : ER-responsive cells . Negative_regulation EPHB2 MAP2K2 15525763 1329490 Perturbation of STAT signaling by a STAT inhibitor peptide or a dominant negative STAT3 mutant causes enhanced production of rod photoreceptors in the absence of exogenous cytokines , whereas inhibiting [ERK] *activation* by a ( mitogen activated protein kinase kinase ) -specific inhibitor has no effect on rod photoreceptor differentiation in vitro . Negative_regulation EPHB2 MAP2K2 16237176 1470792 Consistent with a presynaptic function for endogenous H-ras/extracellular signal regulated kinase ( ERK ) signaling , we observed that , under normal physiologic conditions in wild-type mice , hippocampus dependent learning stimulated the ERK dependent phosphorylation of synapsin I , and ( MAP kinase kinase ) [/ERK] *inhibition* selectively decreased the frequency of miniature EPSCs . Negative_regulation EPHB2 MAP2K2 19219045 2044448 Thus , in disagreement with the current perception of the pathway , the *role* of Mek1 and in growth factor induced [Erk] phosphorylation is not interchangeable . Negative_regulation EPHB2 MAP2K2 19703440 2158072 Furthermore , [ERK] *activation* and angiogenic sprouting in response to NMB are significantly blocked by the inhibitor . Negative_regulation EPHB2 MAP2K2 20179103 2215771 Active as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to *suppress* BPGAP1 induced acute [Erk] activation and cell migration . Negative_regulation EPHB2 MAP2K2 20526801 2320133 Furthermore , we also demonstrate that either chemical inhibition of ( U0126 ) or stable downregulation of PDGFRß by shRNA similarly *results* in the loss of PDGF induced [ERK] phosphorylation and abolishes Rac1/Pak1 activation and cell migration in response to PDGF . Negative_regulation EPHB2 MAP2K2 20810616 2341719 We found that nanomolar concentrations of Sorafenib reduced the basal activity of [ERK] , *inhibited* cAMP dependent activation of B-Raf and signaling , and caused a concentration dependent inhibition of cell proliferation induced by cAMP , epidermal growth factor , or the combination of the two agonists . Negative_regulation EPHB2 MAP2K2 21088259 2389765 These cells displayed high levels of [ERK] activation , that is , at least in part , independent of the conventional RAF/MEK/ERK pathway , as MEK activation was low and inhibition of did not significantly *block* activation of ERK . Negative_regulation EPHB2 MAP2K2 21166955 2378669 Thus , it is suggested that the anti-angiogenic effect of HA1077 may be due to the combination of ROCK inhibition and ( MEK ) [/ERK] pathway *inhibition* . Negative_regulation EPHB2 MAP2K2 22056560 2513934 We found that [Erk] *activation* by overexpression of constitutively active increased the mRNA and protein levels of Osterix and enhanced the transcriptional activity of Osterix , whereas U0126 , an inhibitor of MEK , suppressed the protein levels of Osterix and the transcriptional activity . Negative_regulation EPHB2 MAP2K2 24265154 2898248 The continued MAPK signaling based resistance identified in these patients suggests that alternative dosing of current agents , more potent inhibitors , and/or *inhibition* of the downstream kinase [ERK] may be needed for durable control of BRAF-mutant melanoma . Negative_regulation EPHB2 MAP2K2 8552085 347130 Expression of a dominant interfering mutant , in which lysine 97 was replaced with arginine ( MEK/K97R ) , resulted in an *inhibition* of insulin stimulated SOS and [ERK] phosphorylation , whereas expression of a constitutively active MEK mutant , in which serines 218 and 222 were replaced with glutamic acid ( MEK/EE ) , induced basal phosphorylation of both SOS and ERK . Negative_regulation EPHB2 MAP2K2 9442025 482980 [ERK] activation is strongly *enhanced* by overexpression of p38 and 6 ( MKK6 ) but is blocked by dominant negative kinase versions of p38 and MKK6 or the specific p38 inhibitor SB203580 . Negative_regulation EPHB2 MAP2K2 9790922 542467 The peptide response was not inhibited by the inhibitor ( PD098059 ) and did not *stimulate* [Erk] phosphorylation . Negative_regulation EPHB2 MAP2K3 11230290 789234 VSMC migration in response to OA alone and with Ang II was also inhibited by N : -acetyl-cysteine , *inhibition* , and [ERK] antisense . Negative_regulation EPHB2 MAP2K3 11418608 843256 VPA induced activation of [ERK] was *blocked* by the mitogen activated protein kinase/ERK kinase inhibitor PD098059 and dominant negative Ras and Raf mutants but not by dominant negative stress activated protein kinase/ERK kinase and 6 mutants . Negative_regulation EPHB2 MAP2K3 11834245 910356 Furthermore , ( MEK)-1-specific inhibitor , 2- ( 2-amino-3-methoxyphenyl ) -4H-1-benzopyran-4-one ( PD 98059 ) , *blocked* the lipopolysaccharide induced p44/42 [ERK] activation and PDGF production . Negative_regulation EPHB2 MAP2K3 12364324 1019035 GLP1 stimulated *activation* of [Erk] is blocked by inhibitors of , but GLP1 does not induce the activation of A-Raf , B-Raf , C-Raf , or Ras . Negative_regulation EPHB2 MAP2K3 12657694 1073279 [ERK] *activation* was blocked by inhibiting , the upstream activator of ERK . Negative_regulation EPHB2 MAP2K3 12694865 1080923 U0126 , at concentrations consistent with inhibition of the isolated enzyme , *inhibited* [ERK] phosphorylation , and therefore activation , in response to each agonist . Negative_regulation EPHB2 MAP2K3 12738796 1107258 Surprisingly , this induction of phosphorylation does not *result* in [ERK] activation in vivo . Negative_regulation EPHB2 MAP2K3 14581482 1186915 Either PD98059 or U0126 , selective inhibitors of , or overexpression of a dominant negative MEK-1 inhibited interleukin-1beta- *induced* [ERK] activation and the expression of iNOS and COX-2 but had essentially no effect on the expression of VCAM-1 and Mn-SOD . Negative_regulation EPHB2 MAP2K3 14982949 1250927 Constitutively active ( MEK ) induced MIP-1alpha , and Ras dominant negative ( DN ) *inhibited* IC-induced [ERK] phosphorylation and MIP-1alpha production . Negative_regulation EPHB2 MAP2K3 15177934 1255132 The effects of NT on [EGFR/ERK/Akt] activation and DNA synthesis were *attenuated* by PLC-inhibitor ( U73122 ) , PKC-inhibitors ( bisindolylmaleimide , staurosporine , rottlerin ) , inhibitor ( U0126 ) and PI3 kinase inhibitors ( wortmannin , LY 294002 ) . Negative_regulation EPHB2 MAP2K3 15284289 1277889 In contrast , a mitogen activated protein (MAP) kinase/extracellular signal regulated kinase ( ERK ) kinase ( ) [/ERK] *inhibitor* , PD98059 , completely abrogated the effect of high glucose . Negative_regulation EPHB2 MAP2K3 15361836 1303929 or PI3K inhibitors *suppressed* [ERK] or Akt activation , respectively , and induced apoptosis in the v-ErbB : ER-responsive cells . Negative_regulation EPHB2 MAP2K3 15525763 1329491 Perturbation of STAT signaling by a STAT inhibitor peptide or a dominant negative STAT3 mutant causes enhanced production of rod photoreceptors in the absence of exogenous cytokines , whereas inhibiting [ERK] *activation* by a ( mitogen activated protein kinase kinase ) -specific inhibitor has no effect on rod photoreceptor differentiation in vitro . Negative_regulation EPHB2 MAP2K3 16237176 1470793 Consistent with a presynaptic function for endogenous H-ras/extracellular signal regulated kinase ( ERK ) signaling , we observed that , under normal physiologic conditions in wild-type mice , hippocampus dependent learning stimulated the ERK dependent phosphorylation of synapsin I , and ( MAP kinase kinase ) [/ERK] *inhibition* selectively decreased the frequency of miniature EPSCs . Negative_regulation EPHB2 MAP2K3 19703440 2158073 Furthermore , [ERK] *activation* and angiogenic sprouting in response to NMB are significantly blocked by the inhibitor . Negative_regulation EPHB2 MAP2K3 20526801 2320134 Furthermore , we also demonstrate that either chemical inhibition of ( U0126 ) or stable downregulation of PDGFRß by shRNA similarly *results* in the loss of PDGF induced [ERK] phosphorylation and abolishes Rac1/Pak1 activation and cell migration in response to PDGF . Negative_regulation EPHB2 MAP2K3 20810616 2341720 We found that nanomolar concentrations of Sorafenib reduced the basal activity of [ERK] , *inhibited* cAMP dependent activation of B-Raf and signaling , and caused a concentration dependent inhibition of cell proliferation induced by cAMP , epidermal growth factor , or the combination of the two agonists . Negative_regulation EPHB2 MAP2K3 21088259 2389766 These cells displayed high levels of [ERK] activation , that is , at least in part , independent of the conventional RAF/MEK/ERK pathway , as MEK activation was low and inhibition of did not significantly *block* activation of ERK . Negative_regulation EPHB2 MAP2K3 21166955 2378670 Thus , it is suggested that the anti-angiogenic effect of HA1077 may be due to the combination of ROCK inhibition and ( MEK ) [/ERK] pathway *inhibition* . Negative_regulation EPHB2 MAP2K3 22056560 2513935 We found that [Erk] *activation* by overexpression of constitutively active increased the mRNA and protein levels of Osterix and enhanced the transcriptional activity of Osterix , whereas U0126 , an inhibitor of MEK , suppressed the protein levels of Osterix and the transcriptional activity . Negative_regulation EPHB2 MAP2K3 24265154 2898249 The continued MAPK signaling based resistance identified in these patients suggests that alternative dosing of current agents , more potent inhibitors , and/or *inhibition* of the downstream kinase [ERK] may be needed for durable control of BRAF-mutant melanoma . Negative_regulation EPHB2 MAP2K3 8552085 347131 Expression of a dominant interfering mutant , in which lysine 97 was replaced with arginine ( MEK/K97R ) , *resulted* in an inhibition of insulin stimulated SOS and [ERK] phosphorylation , whereas expression of a constitutively active MEK mutant , in which serines 218 and 222 were replaced with glutamic acid ( MEK/EE ) , induced basal phosphorylation of both SOS and ERK . Negative_regulation EPHB2 MAP2K3 9442025 482981 [ERK] activation is strongly *enhanced* by overexpression of p38 and 6 ( MKK6 ) but is blocked by dominant negative kinase versions of p38 and MKK6 or the specific p38 inhibitor SB203580 . Negative_regulation EPHB2 MAP2K3 9790922 542468 The peptide response was not inhibited by the inhibitor ( PD098059 ) and did not *stimulate* [Erk] phosphorylation . Negative_regulation EPHB2 MAP2K4 11230290 789235 VSMC migration in response to OA alone and with Ang II was also inhibited by N : -acetyl-cysteine , *inhibition* , and [ERK] antisense . Negative_regulation EPHB2 MAP2K4 11418608 843257 VPA induced activation of [ERK] was *blocked* by the mitogen activated protein kinase/ERK kinase inhibitor PD098059 and dominant negative Ras and Raf mutants but not by dominant negative stress activated protein kinase/ERK kinase and 6 mutants . Negative_regulation EPHB2 MAP2K4 11834245 910357 Furthermore , ( MEK)-1-specific inhibitor , 2- ( 2-amino-3-methoxyphenyl ) -4H-1-benzopyran-4-one ( PD 98059 ) , *blocked* the lipopolysaccharide induced p44/42 [ERK] activation and PDGF production . Negative_regulation EPHB2 MAP2K4 12364324 1019036 GLP1 stimulated *activation* of [Erk] is blocked by inhibitors of , but GLP1 does not induce the activation of A-Raf , B-Raf , C-Raf , or Ras . Negative_regulation EPHB2 MAP2K4 12657694 1073280 [ERK] *activation* was blocked by inhibiting , the upstream activator of ERK . Negative_regulation EPHB2 MAP2K4 12694865 1080924 U0126 , at concentrations consistent with inhibition of the isolated enzyme , *inhibited* [ERK] phosphorylation , and therefore activation , in response to each agonist . Negative_regulation EPHB2 MAP2K4 12738796 1107259 Surprisingly , this induction of phosphorylation does not *result* in [ERK] activation in vivo . Negative_regulation EPHB2 MAP2K4 14581482 1186916 Either PD98059 or U0126 , selective inhibitors of , or overexpression of a dominant negative MEK-1 inhibited interleukin-1beta- *induced* [ERK] activation and the expression of iNOS and COX-2 but had essentially no effect on the expression of VCAM-1 and Mn-SOD . Negative_regulation EPHB2 MAP2K4 14982949 1250928 Constitutively active ( MEK ) induced MIP-1alpha , and Ras dominant negative ( DN ) *inhibited* IC-induced [ERK] phosphorylation and MIP-1alpha production . Negative_regulation EPHB2 MAP2K4 15177934 1255133 The effects of NT on [EGFR/ERK/Akt] activation and DNA synthesis were *attenuated* by PLC-inhibitor ( U73122 ) , PKC-inhibitors ( bisindolylmaleimide , staurosporine , rottlerin ) , inhibitor ( U0126 ) and PI3 kinase inhibitors ( wortmannin , LY 294002 ) . Negative_regulation EPHB2 MAP2K4 15284289 1277890 In contrast , a mitogen activated protein (MAP) kinase/extracellular signal regulated kinase ( [ERK] ) kinase ( ) /ERK *inhibitor* , PD98059 , completely abrogated the effect of high glucose . Negative_regulation EPHB2 MAP2K4 15361836 1303930 or PI3K inhibitors *suppressed* [ERK] or Akt activation , respectively , and induced apoptosis in the v-ErbB : ER-responsive cells . Negative_regulation EPHB2 MAP2K4 15525763 1329492 Perturbation of STAT signaling by a STAT inhibitor peptide or a dominant negative STAT3 mutant causes enhanced production of rod photoreceptors in the absence of exogenous cytokines , whereas inhibiting [ERK] *activation* by a ( mitogen activated protein kinase kinase ) -specific inhibitor has no effect on rod photoreceptor differentiation in vitro . Negative_regulation EPHB2 MAP2K4 16237176 1470794 Consistent with a presynaptic function for endogenous H-ras/extracellular signal regulated kinase ( ERK ) signaling , we observed that , under normal physiologic conditions in wild-type mice , hippocampus dependent learning stimulated the ERK dependent phosphorylation of synapsin I , and ( MAP kinase kinase ) [/ERK] *inhibition* selectively decreased the frequency of miniature EPSCs . Negative_regulation EPHB2 MAP2K4 17643960 1780297 Consistently , overexpression of MEK1 and constitutively active in U87 cells *led* to [ERK] and JNK activation , respectively , which was accompanied with markedly increased GFAP production . Negative_regulation EPHB2 MAP2K4 19026990 2022785 The phosphorylation of c-Jun N-terminal kinase (JNK) and [ERK] was *inhibited* by myricetin , but not the phosphorylation of their upstream kinases and MEK1 . Negative_regulation EPHB2 MAP2K4 19703440 2158074 Furthermore , [ERK] *activation* and angiogenic sprouting in response to NMB are significantly blocked by the inhibitor . Negative_regulation EPHB2 MAP2K4 20526801 2320135 Furthermore , we also demonstrate that either chemical inhibition of ( U0126 ) or stable downregulation of PDGFRß by shRNA similarly *results* in the loss of PDGF induced [ERK] phosphorylation and abolishes Rac1/Pak1 activation and cell migration in response to PDGF . Negative_regulation EPHB2 MAP2K4 20810616 2341721 We found that nanomolar concentrations of Sorafenib reduced the basal activity of [ERK] , *inhibited* cAMP dependent activation of B-Raf and signaling , and caused a concentration dependent inhibition of cell proliferation induced by cAMP , epidermal growth factor , or the combination of the two agonists . Negative_regulation EPHB2 MAP2K4 21088259 2389767 These cells displayed high levels of [ERK] activation , that is , at least in part , independent of the conventional RAF/MEK/ERK pathway , as MEK activation was low and inhibition of did not significantly *block* activation of ERK . Negative_regulation EPHB2 MAP2K4 21166955 2378671 Thus , it is suggested that the anti-angiogenic effect of HA1077 may be due to the combination of ROCK inhibition and ( MEK ) [/ERK] pathway *inhibition* . Negative_regulation EPHB2 MAP2K4 22056560 2513936 We found that [Erk] *activation* by overexpression of constitutively active increased the mRNA and protein levels of Osterix and enhanced the transcriptional activity of Osterix , whereas U0126 , an inhibitor of MEK , suppressed the protein levels of Osterix and the transcriptional activity . Negative_regulation EPHB2 MAP2K4 24265154 2898250 The continued MAPK signaling based resistance identified in these patients suggests that alternative dosing of current agents , more potent inhibitors , and/or *inhibition* of the downstream kinase [ERK] may be needed for durable control of BRAF-mutant melanoma . Negative_regulation EPHB2 MAP2K4 8552085 347132 Expression of a dominant interfering mutant , in which lysine 97 was replaced with arginine ( MEK/K97R ) , resulted in an *inhibition* of insulin stimulated SOS and [ERK] phosphorylation , whereas expression of a constitutively active MEK mutant , in which serines 218 and 222 were replaced with glutamic acid ( MEK/EE ) , induced basal phosphorylation of both SOS and ERK . Negative_regulation EPHB2 MAP2K4 9442025 482982 [ERK] activation is strongly *enhanced* by overexpression of p38 and 6 ( MKK6 ) but is blocked by dominant negative kinase versions of p38 and MKK6 or the specific p38 inhibitor SB203580 . Negative_regulation EPHB2 MAP2K4 9790922 542469 The peptide response was not inhibited by the inhibitor ( PD098059 ) and did not *stimulate* [Erk] phosphorylation . Negative_regulation EPHB2 MAP2K5 11230290 789236 VSMC migration in response to OA alone and with Ang II was also inhibited by N : -acetyl-cysteine , *inhibition* , and [ERK] antisense . Negative_regulation EPHB2 MAP2K5 11418608 843258 VPA induced activation of [ERK] was *blocked* by the mitogen activated protein kinase/ERK kinase inhibitor PD098059 and dominant negative Ras and Raf mutants but not by dominant negative stress activated protein kinase/ERK kinase and 6 mutants . Negative_regulation EPHB2 MAP2K5 11834245 910358 Furthermore , ( MEK)-1-specific inhibitor , 2- ( 2-amino-3-methoxyphenyl ) -4H-1-benzopyran-4-one ( PD 98059 ) , *blocked* the lipopolysaccharide induced p44/42 [ERK] activation and PDGF production . Negative_regulation EPHB2 MAP2K5 12364324 1019037 GLP1 stimulated *activation* of [Erk] is blocked by inhibitors of , but GLP1 does not induce the activation of A-Raf , B-Raf , C-Raf , or Ras . Negative_regulation EPHB2 MAP2K5 12657694 1073281 [ERK] *activation* was blocked by inhibiting , the upstream activator of ERK . Negative_regulation EPHB2 MAP2K5 12694865 1080925 U0126 , at concentrations consistent with inhibition of the isolated enzyme , *inhibited* [ERK] phosphorylation , and therefore activation , in response to each agonist . Negative_regulation EPHB2 MAP2K5 12738796 1107260 Surprisingly , this induction of phosphorylation does not *result* in [ERK] activation in vivo . Negative_regulation EPHB2 MAP2K5 14581482 1186917 Either PD98059 or U0126 , selective inhibitors of , or overexpression of a dominant negative MEK-1 inhibited interleukin-1beta- *induced* [ERK] activation and the expression of iNOS and COX-2 but had essentially no effect on the expression of VCAM-1 and Mn-SOD . Negative_regulation EPHB2 MAP2K5 14982949 1250929 Constitutively active ( MEK ) induced MIP-1alpha , and Ras dominant negative ( DN ) *inhibited* IC-induced [ERK] phosphorylation and MIP-1alpha production . Negative_regulation EPHB2 MAP2K5 15177934 1255134 The effects of NT on [EGFR/ERK/Akt] activation and DNA synthesis were *attenuated* by PLC-inhibitor ( U73122 ) , PKC-inhibitors ( bisindolylmaleimide , staurosporine , rottlerin ) , inhibitor ( U0126 ) and PI3 kinase inhibitors ( wortmannin , LY 294002 ) . Negative_regulation EPHB2 MAP2K5 15284289 1277891 In contrast , a mitogen activated protein (MAP) kinase/extracellular signal regulated kinase ( ERK ) kinase ( ) [/ERK] *inhibitor* , PD98059 , completely abrogated the effect of high glucose . Negative_regulation EPHB2 MAP2K5 15361836 1303931 or PI3K inhibitors *suppressed* [ERK] or Akt activation , respectively , and induced apoptosis in the v-ErbB : ER-responsive cells . Negative_regulation EPHB2 MAP2K5 15525763 1329493 Perturbation of STAT signaling by a STAT inhibitor peptide or a dominant negative STAT3 mutant causes enhanced production of rod photoreceptors in the absence of exogenous cytokines , whereas inhibiting [ERK] *activation* by a ( mitogen activated protein kinase kinase ) -specific inhibitor has no effect on rod photoreceptor differentiation in vitro . Negative_regulation EPHB2 MAP2K5 16237176 1470795 Consistent with a presynaptic function for endogenous H-ras/extracellular signal regulated kinase ( ERK ) signaling , we observed that , under normal physiologic conditions in wild-type mice , hippocampus dependent learning stimulated the ERK dependent phosphorylation of synapsin I , and ( MAP kinase kinase ) [/ERK] *inhibition* selectively decreased the frequency of miniature EPSCs . Negative_regulation EPHB2 MAP2K5 19703440 2158075 Furthermore , [ERK] *activation* and angiogenic sprouting in response to NMB are significantly blocked by the inhibitor . Negative_regulation EPHB2 MAP2K5 20526801 2320136 Furthermore , we also demonstrate that either chemical inhibition of ( U0126 ) or stable downregulation of PDGFRß by shRNA similarly *results* in the loss of PDGF induced [ERK] phosphorylation and abolishes Rac1/Pak1 activation and cell migration in response to PDGF . Negative_regulation EPHB2 MAP2K5 20810616 2341722 We found that nanomolar concentrations of Sorafenib reduced the basal activity of [ERK] , *inhibited* cAMP dependent activation of B-Raf and signaling , and caused a concentration dependent inhibition of cell proliferation induced by cAMP , epidermal growth factor , or the combination of the two agonists . Negative_regulation EPHB2 MAP2K5 21088259 2389768 These cells displayed high levels of [ERK] activation , that is , at least in part , independent of the conventional RAF/MEK/ERK pathway , as MEK activation was low and inhibition of did not significantly *block* activation of ERK . Negative_regulation EPHB2 MAP2K5 21166955 2378672 Thus , it is suggested that the anti-angiogenic effect of HA1077 may be due to the combination of ROCK inhibition and ( MEK ) [/ERK] pathway *inhibition* . Negative_regulation EPHB2 MAP2K5 22056560 2513937 We found that [Erk] *activation* by overexpression of constitutively active increased the mRNA and protein levels of Osterix and enhanced the transcriptional activity of Osterix , whereas U0126 , an inhibitor of MEK , suppressed the protein levels of Osterix and the transcriptional activity . Negative_regulation EPHB2 MAP2K5 24265154 2898251 The continued MAPK signaling based resistance identified in these patients suggests that alternative dosing of current agents , more potent inhibitors , and/or *inhibition* of the downstream kinase [ERK] may be needed for durable control of BRAF-mutant melanoma . Negative_regulation EPHB2 MAP2K5 8552085 347133 Expression of a dominant interfering mutant , in which lysine 97 was replaced with arginine ( MEK/K97R ) , *resulted* in an inhibition of insulin stimulated SOS and [ERK] phosphorylation , whereas expression of a constitutively active MEK mutant , in which serines 218 and 222 were replaced with glutamic acid ( MEK/EE ) , induced basal phosphorylation of both SOS and ERK . Negative_regulation EPHB2 MAP2K5 9442025 482983 [ERK] activation is strongly *enhanced* by overexpression of p38 and 6 ( MKK6 ) but is blocked by dominant negative kinase versions of p38 and MKK6 or the specific p38 inhibitor SB203580 . Negative_regulation EPHB2 MAP2K5 9790922 542470 The peptide response was not inhibited by the inhibitor ( PD098059 ) and did not *stimulate* [Erk] phosphorylation . Negative_regulation EPHB2 MAP2K6 11230290 789237 VSMC migration in response to OA alone and with Ang II was also inhibited by N : -acetyl-cysteine , *inhibition* , and [ERK] antisense . Negative_regulation EPHB2 MAP2K6 11418608 843259 VPA induced activation of [ERK] was *blocked* by the mitogen activated protein kinase/ERK kinase inhibitor PD098059 and dominant negative Ras and Raf mutants but not by dominant negative stress activated protein kinase/ERK kinase and 6 mutants . Negative_regulation EPHB2 MAP2K6 11834245 910359 Furthermore , ( MEK)-1-specific inhibitor , 2- ( 2-amino-3-methoxyphenyl ) -4H-1-benzopyran-4-one ( PD 98059 ) , *blocked* the lipopolysaccharide induced p44/42 [ERK] activation and PDGF production . Negative_regulation EPHB2 MAP2K6 12364324 1019038 GLP1 stimulated *activation* of [Erk] is blocked by inhibitors of , but GLP1 does not induce the activation of A-Raf , B-Raf , C-Raf , or Ras . Negative_regulation EPHB2 MAP2K6 12657694 1073282 [ERK] *activation* was blocked by inhibiting , the upstream activator of ERK . Negative_regulation EPHB2 MAP2K6 12694865 1080926 U0126 , at concentrations consistent with inhibition of the isolated enzyme , *inhibited* [ERK] phosphorylation , and therefore activation , in response to each agonist . Negative_regulation EPHB2 MAP2K6 12738796 1107261 Surprisingly , this induction of phosphorylation does not *result* in [ERK] activation in vivo . Negative_regulation EPHB2 MAP2K6 14581482 1186918 Either PD98059 or U0126 , selective inhibitors of , or overexpression of a dominant negative MEK-1 inhibited interleukin-1beta- *induced* [ERK] activation and the expression of iNOS and COX-2 but had essentially no effect on the expression of VCAM-1 and Mn-SOD . Negative_regulation EPHB2 MAP2K6 14982949 1250930 Constitutively active ( MEK ) induced MIP-1alpha , and Ras dominant negative ( DN ) *inhibited* IC-induced [ERK] phosphorylation and MIP-1alpha production . Negative_regulation EPHB2 MAP2K6 15177934 1255135 The effects of NT on [EGFR/ERK/Akt] activation and DNA synthesis were *attenuated* by PLC-inhibitor ( U73122 ) , PKC-inhibitors ( bisindolylmaleimide , staurosporine , rottlerin ) , inhibitor ( U0126 ) and PI3 kinase inhibitors ( wortmannin , LY 294002 ) . Negative_regulation EPHB2 MAP2K6 15284289 1277892 In contrast , a mitogen activated protein (MAP) kinase/extracellular signal regulated kinase ( [ERK] ) kinase ( ) /ERK *inhibitor* , PD98059 , completely abrogated the effect of high glucose . Negative_regulation EPHB2 MAP2K6 15361836 1303932 or PI3K inhibitors *suppressed* [ERK] or Akt activation , respectively , and induced apoptosis in the v-ErbB : ER-responsive cells . Negative_regulation EPHB2 MAP2K6 15525763 1329494 Perturbation of STAT signaling by a STAT inhibitor peptide or a dominant negative STAT3 mutant causes enhanced production of rod photoreceptors in the absence of exogenous cytokines , whereas inhibiting [ERK] *activation* by a ( mitogen activated protein kinase kinase ) -specific inhibitor has no effect on rod photoreceptor differentiation in vitro . Negative_regulation EPHB2 MAP2K6 15790570 1410265 expression was *sufficient* to inhibit [ERK] phosphorylation triggered by growth factors and integrin engagement . Negative_regulation EPHB2 MAP2K6 16237176 1470796 Consistent with a presynaptic function for endogenous H-ras/extracellular signal regulated kinase ( ERK ) signaling , we observed that , under normal physiologic conditions in wild-type mice , hippocampus dependent learning stimulated the ERK dependent phosphorylation of synapsin I , and ( MAP kinase kinase ) [/ERK] *inhibition* selectively decreased the frequency of miniature EPSCs . Negative_regulation EPHB2 MAP2K6 19703440 2158076 Furthermore , [ERK] *activation* and angiogenic sprouting in response to NMB are significantly blocked by the inhibitor . Negative_regulation EPHB2 MAP2K6 20526801 2320137 Furthermore , we also demonstrate that either chemical inhibition of ( U0126 ) or stable downregulation of PDGFRß by shRNA similarly *results* in the loss of PDGF induced [ERK] phosphorylation and abolishes Rac1/Pak1 activation and cell migration in response to PDGF . Negative_regulation EPHB2 MAP2K6 20810616 2341723 We found that nanomolar concentrations of Sorafenib reduced the basal activity of [ERK] , *inhibited* cAMP dependent activation of B-Raf and signaling , and caused a concentration dependent inhibition of cell proliferation induced by cAMP , epidermal growth factor , or the combination of the two agonists . Negative_regulation EPHB2 MAP2K6 21088259 2389769 These cells displayed high levels of [ERK] activation , that is , at least in part , independent of the conventional RAF/MEK/ERK pathway , as MEK activation was low and inhibition of did not significantly *block* activation of ERK . Negative_regulation EPHB2 MAP2K6 21166955 2378673 Thus , it is suggested that the anti-angiogenic effect of HA1077 may be due to the combination of ROCK inhibition and ( MEK ) [/ERK] pathway *inhibition* . Negative_regulation EPHB2 MAP2K6 22056560 2513938 We found that [Erk] *activation* by overexpression of constitutively active increased the mRNA and protein levels of Osterix and enhanced the transcriptional activity of Osterix , whereas U0126 , an inhibitor of MEK , suppressed the protein levels of Osterix and the transcriptional activity . Negative_regulation EPHB2 MAP2K6 24265154 2898252 The continued MAPK signaling based resistance identified in these patients suggests that alternative dosing of current agents , more potent inhibitors , and/or *inhibition* of the downstream kinase [ERK] may be needed for durable control of BRAF-mutant melanoma . Negative_regulation EPHB2 MAP2K6 8552085 347134 Expression of a dominant interfering mutant , in which lysine 97 was replaced with arginine ( MEK/K97R ) , resulted in an *inhibition* of insulin stimulated SOS and [ERK] phosphorylation , whereas expression of a constitutively active MEK mutant , in which serines 218 and 222 were replaced with glutamic acid ( MEK/EE ) , induced basal phosphorylation of both SOS and ERK . Negative_regulation EPHB2 MAP2K6 9442025 482984 [ERK] activation is strongly *enhanced* by overexpression of p38 and 6 ( MKK6 ) but is blocked by dominant negative kinase versions of p38 and MKK6 or the specific p38 inhibitor SB203580 . Negative_regulation EPHB2 MAP2K6 9790922 542471 The peptide response was not inhibited by the inhibitor ( PD098059 ) and did not *stimulate* [Erk] phosphorylation . Negative_regulation EPHB2 MAP2K7 11230290 789238 VSMC migration in response to OA alone and with Ang II was also inhibited by N : -acetyl-cysteine , *inhibition* , and [ERK] antisense . Negative_regulation EPHB2 MAP2K7 11418608 843260 VPA induced activation of [ERK] was *blocked* by the mitogen activated protein kinase/ERK kinase inhibitor PD098059 and dominant negative Ras and Raf mutants but not by dominant negative stress activated protein kinase/ERK kinase and 6 mutants . Negative_regulation EPHB2 MAP2K7 11834245 910360 Furthermore , ( MEK)-1-specific inhibitor , 2- ( 2-amino-3-methoxyphenyl ) -4H-1-benzopyran-4-one ( PD 98059 ) , *blocked* the lipopolysaccharide induced p44/42 [ERK] activation and PDGF production . Negative_regulation EPHB2 MAP2K7 12364324 1019039 GLP1 stimulated *activation* of [Erk] is blocked by inhibitors of , but GLP1 does not induce the activation of A-Raf , B-Raf , C-Raf , or Ras . Negative_regulation EPHB2 MAP2K7 12657694 1073283 [ERK] *activation* was blocked by inhibiting , the upstream activator of ERK . Negative_regulation EPHB2 MAP2K7 12694865 1080927 U0126 , at concentrations consistent with inhibition of the isolated enzyme , *inhibited* [ERK] phosphorylation , and therefore activation , in response to each agonist . Negative_regulation EPHB2 MAP2K7 12738796 1107262 Surprisingly , this induction of phosphorylation does not *result* in [ERK] activation in vivo . Negative_regulation EPHB2 MAP2K7 14581482 1186919 Either PD98059 or U0126 , selective inhibitors of , or overexpression of a dominant negative MEK-1 inhibited interleukin-1beta- *induced* [ERK] activation and the expression of iNOS and COX-2 but had essentially no effect on the expression of VCAM-1 and Mn-SOD . Negative_regulation EPHB2 MAP2K7 14982949 1250931 Constitutively active ( MEK ) induced MIP-1alpha , and Ras dominant negative ( DN ) *inhibited* IC-induced [ERK] phosphorylation and MIP-1alpha production . Negative_regulation EPHB2 MAP2K7 15177934 1255136 The effects of NT on [EGFR/ERK/Akt] activation and DNA synthesis were *attenuated* by PLC-inhibitor ( U73122 ) , PKC-inhibitors ( bisindolylmaleimide , staurosporine , rottlerin ) , inhibitor ( U0126 ) and PI3 kinase inhibitors ( wortmannin , LY 294002 ) . Negative_regulation EPHB2 MAP2K7 15284289 1277893 In contrast , a mitogen activated protein (MAP) kinase/extracellular signal regulated kinase ( ERK ) kinase ( ) [/ERK] *inhibitor* , PD98059 , completely abrogated the effect of high glucose . Negative_regulation EPHB2 MAP2K7 15361836 1303933 or PI3K inhibitors *suppressed* [ERK] or Akt activation , respectively , and induced apoptosis in the v-ErbB : ER-responsive cells . Negative_regulation EPHB2 MAP2K7 15525763 1329495 Perturbation of STAT signaling by a STAT inhibitor peptide or a dominant negative STAT3 mutant causes enhanced production of rod photoreceptors in the absence of exogenous cytokines , whereas inhibiting [ERK] *activation* by a ( mitogen activated protein kinase kinase ) -specific inhibitor has no effect on rod photoreceptor differentiation in vitro . Negative_regulation EPHB2 MAP2K7 16237176 1470797 Consistent with a presynaptic function for endogenous H-ras/extracellular signal regulated kinase ( ERK ) signaling , we observed that , under normal physiologic conditions in wild-type mice , hippocampus dependent learning stimulated the ERK dependent phosphorylation of synapsin I , and ( MAP kinase kinase ) [/ERK] *inhibition* selectively decreased the frequency of miniature EPSCs . Negative_regulation EPHB2 MAP2K7 19703440 2158077 Furthermore , [ERK] *activation* and angiogenic sprouting in response to NMB are significantly blocked by the inhibitor . Negative_regulation EPHB2 MAP2K7 20526801 2320138 Furthermore , we also demonstrate that either chemical inhibition of ( U0126 ) or stable downregulation of PDGFRß by shRNA similarly *results* in the loss of PDGF induced [ERK] phosphorylation and abolishes Rac1/Pak1 activation and cell migration in response to PDGF . Negative_regulation EPHB2 MAP2K7 20810616 2341724 We found that nanomolar concentrations of Sorafenib reduced the basal activity of [ERK] , *inhibited* cAMP dependent activation of B-Raf and signaling , and caused a concentration dependent inhibition of cell proliferation induced by cAMP , epidermal growth factor , or the combination of the two agonists . Negative_regulation EPHB2 MAP2K7 21088259 2389770 These cells displayed high levels of [ERK] activation , that is , at least in part , independent of the conventional RAF/MEK/ERK pathway , as MEK activation was low and inhibition of did not significantly *block* activation of ERK . Negative_regulation EPHB2 MAP2K7 21166955 2378674 Thus , it is suggested that the anti-angiogenic effect of HA1077 may be due to the combination of ROCK inhibition and ( MEK ) [/ERK] pathway *inhibition* . Negative_regulation EPHB2 MAP2K7 22056560 2513939 We found that [Erk] *activation* by overexpression of constitutively active increased the mRNA and protein levels of Osterix and enhanced the transcriptional activity of Osterix , whereas U0126 , an inhibitor of MEK , suppressed the protein levels of Osterix and the transcriptional activity . Negative_regulation EPHB2 MAP2K7 24265154 2898253 The continued MAPK signaling based resistance identified in these patients suggests that alternative dosing of current agents , more potent inhibitors , and/or *inhibition* of the downstream kinase [ERK] may be needed for durable control of BRAF-mutant melanoma . Negative_regulation EPHB2 MAP2K7 8552085 347135 Expression of a dominant interfering mutant , in which lysine 97 was replaced with arginine ( MEK/K97R ) , *resulted* in an inhibition of insulin stimulated SOS and [ERK] phosphorylation , whereas expression of a constitutively active MEK mutant , in which serines 218 and 222 were replaced with glutamic acid ( MEK/EE ) , induced basal phosphorylation of both SOS and ERK . Negative_regulation EPHB2 MAP2K7 9442025 482985 [ERK] activation is strongly *enhanced* by overexpression of p38 and 6 ( MKK6 ) but is blocked by dominant negative kinase versions of p38 and MKK6 or the specific p38 inhibitor SB203580 . Negative_regulation EPHB2 MAP2K7 9790922 542472 The peptide response was not inhibited by the inhibitor ( PD098059 ) and did not *stimulate* [Erk] phosphorylation . Negative_regulation EPHB2 MAP3K1 9305638 454074 Kinase-inactive , but not MEKK2 , 3 or 4 , strongly *inhibited* EGF stimulated [ERK] activity . Negative_regulation EPHB2 MAP3K2 10549623 565002 Biochemical activation of follows TCR stimulation , and expression of a dominant negative MEKK2 *inhibits* TCR mediated conjugate stabilization and [ERK] and p38 MAP kinase phosphorylation . Negative_regulation EPHB2 MAP3K2 23963453 2845520 Expression of T283A within a MEKK2 ( -/- ) background enhanced stress activated c-Jun N-terminal kinase activity while elevating IL-6 expression , but also *reduced* [ERK] activation with a corresponding reduced proliferation rate . Negative_regulation EPHB2 MAP3K2 9305638 454075 Kinase-inactive MEKK1 , but not , 3 or 4 , strongly *inhibited* EGF stimulated [ERK] activity . Negative_regulation EPHB2 MAP3K3 12444545 1017453 Stimulation of the conditional mutant Delta : ER* in asynchronous hamster ( CCl39 ) and rat ( Rat-1 ) fibroblasts *resulted* in the strong activation of endogenous JNK and p38 but only a weak activation of [ERK] . Negative_regulation EPHB2 MAP3K5 23696862 2792027 Meanwhile , suppression of by RNA interference *led* to decreased [ERK] phosphorylation induced by DTCD . Negative_regulation EPHB2 MAP4K1 17115060 1677215 Here , deficiency *resulted* in enhanced TCR induced phosphorylation of SLP-76 , phospholipase C-gamma1 and the kinase [Erk] , more-persistent calcium flux , and increased production of cytokines and antigen-specific antibodies . Negative_regulation EPHB2 MAPK1 11522789 874703 GPIb-IX induced phosphorylation is inhibited by PKG inhibitors and enhanced by overexpression of recombinant PKG. PKG activators also *induce* [ERK] phosphorylation , indicating that activation of MAPK pathway is downstream from PKG . Negative_regulation EPHB2 MAPK1 11874466 918771 Further evidence for differential regulation of RAS and ERK is provided by the observations that TPO , which activates RAS but not protein kinase C , does not activate [ERK] , and that the inhibitor of SRC kinases PP1 *inhibits* activation of RAS but not in response to thrombin . Negative_regulation EPHB2 MAPK1 12419320 1013190 Inhibition of p38 *stimulated* Raf and [ERK] activities , and induced cell proliferation in differentiation medium . Negative_regulation EPHB2 MAPK1 15199145 1260675 The proliferation of MCF-7 cells induced by E2 was significantly inhibited by PD98059 , a specific [ERK] *inhibitor* , or by dominant negative expression and by expression of wt BRCA1 ( but not mutant BRCA1 ) . Negative_regulation EPHB2 MAPK1 15610507 1348258 The heat shock induced MMP-1 and MMP-3 expression was suppressed by the inhibition of [ERK] and JNK but not by p38 *inhibition* . Negative_regulation EPHB2 MAPK1 15640153 1381279 MMP-1 secretion required activation of the MAPK [Erk] and subsequent protein synthesis but was *down-regulated* by the alternate , p38 . Negative_regulation EPHB2 MAPK1 15810889 1392150 Thus , [ERK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation EPHB2 MAPK1 16291589 1525990 TCCM treatment activated p38 and Janus kinase (JNK) but *inhibited* [extracellular regulated kinase (ERK)] . Negative_regulation EPHB2 MAPK1 16291589 1526021 Thus , our results suggested that tumor induced p38 activation and [ERK] *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation EPHB2 MAPK1 16464862 1548086 In contrast , p38 inhibitors *had* no detectable effect on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Negative_regulation EPHB2 MAPK1 16702953 1631390 We previously reported that SNT-2 is not tyrosine phosphorylated significantly in response to epidermal growth factor (EGF) but that it *inhibits* [ERK] activation via EGF stimulation by forming a complex with . Negative_regulation EPHB2 MAPK1 17065146 1654686 *Inhibitors* of [ERK] and JNK ( but not of p38 ) reduced egr-1 expression at the protein level . Negative_regulation EPHB2 MAPK1 17492827 1744369 Examination of potential signalling pathways revealed that FIZZ1 induced rapid phosphorylation of , while PD98059 , a [MEK/ERK] *inhibitor* , markedly induced activation of caspase-3 . Negative_regulation EPHB2 MAPK1 17615677 1769054 We conclude that [ERK] activation and p38 *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation EPHB2 MAPK1 19428337 2076998 Histological examination of lung tissues revealed that [ERK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation EPHB2 MAPK1 21323644 2447664 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) [/ERK] signalling . Negative_regulation EPHB2 MAPK1 21663947 2459743 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation EPHB2 MAPK1 22129743 2515074 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 and Akt phosphorylation , but in contrast , *inhibited* that of [ERK] ( 1/2 ) . Negative_regulation EPHB2 MAPK1 23524336 2777308 tMEK is a novel output from the canonical MAP kinase signalling pathway , acting in a signalling regulated dominant negative manner to *inhibit* [ERK] and p90RSK activations , acting as a dampening mechanism to reduce the magnitude or duration of MAPK pathway signalling in G2/M phase . Negative_regulation EPHB2 MAPK10 12419320 1013191 Inhibition of p38 *stimulated* Raf and [ERK] activities , and induced cell proliferation in differentiation medium . Negative_regulation EPHB2 MAPK10 15610507 1348259 The heat shock induced MMP-1 and MMP-3 expression was suppressed by the inhibition of [ERK] and JNK but not by p38 *inhibition* . Negative_regulation EPHB2 MAPK10 15640153 1381280 MMP-1 secretion required activation of the MAPK [Erk] and subsequent protein synthesis but was *down-regulated* by the alternate , p38 . Negative_regulation EPHB2 MAPK10 15810889 1392151 Thus , [ERK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation EPHB2 MAPK10 16291589 1525991 TCCM treatment activated p38 and Janus kinase (JNK) but *inhibited* [extracellular regulated kinase (ERK)] . Negative_regulation EPHB2 MAPK10 16291589 1526022 Thus , our results suggested that tumor induced p38 activation and [ERK] *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation EPHB2 MAPK10 16464862 1548087 In contrast , p38 inhibitors *had* no detectable effect on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Negative_regulation EPHB2 MAPK10 17065146 1654687 *Inhibitors* of [ERK] and JNK ( but not of p38 ) reduced egr-1 expression at the protein level . Negative_regulation EPHB2 MAPK10 17615677 1769055 We conclude that [ERK] activation and p38 *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation EPHB2 MAPK10 19428337 2076999 Histological examination of lung tissues revealed that [ERK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation EPHB2 MAPK10 21323644 2447665 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) [/ERK] signalling . Negative_regulation EPHB2 MAPK10 21663947 2459744 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation EPHB2 MAPK10 22129743 2515075 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 and Akt phosphorylation , but in contrast , *inhibited* that of [ERK] ( 1/2 ) . Negative_regulation EPHB2 MAPK10 23524336 2777309 tMEK is a novel output from the canonical MAP kinase signalling pathway , acting in a signalling regulated dominant negative manner to *inhibit* [ERK] and p90RSK activations , acting as a dampening mechanism to reduce the magnitude or duration of MAPK pathway signalling in G2/M phase . Negative_regulation EPHB2 MAPK11 12419320 1013192 Inhibition of p38 *stimulated* Raf and [ERK] activities , and induced cell proliferation in differentiation medium . Negative_regulation EPHB2 MAPK11 15610507 1348260 The heat shock induced MMP-1 and MMP-3 expression was suppressed by the inhibition of [ERK] and JNK but not by p38 *inhibition* . Negative_regulation EPHB2 MAPK11 15640153 1381281 MMP-1 secretion required activation of the MAPK [Erk] and subsequent protein synthesis but was *down-regulated* by the alternate , p38 . Negative_regulation EPHB2 MAPK11 15810889 1392152 Thus , [ERK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation EPHB2 MAPK11 16291589 1525992 TCCM treatment activated p38 and Janus kinase (JNK) but *inhibited* [extracellular regulated kinase (ERK)] . Negative_regulation EPHB2 MAPK11 16291589 1526023 Thus , our results suggested that tumor induced p38 activation and [ERK] *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation EPHB2 MAPK11 16464862 1548088 In contrast , p38 inhibitors *had* no detectable effect on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Negative_regulation EPHB2 MAPK11 17065146 1654688 *Inhibitors* of [ERK] and JNK ( but not of p38 ) reduced egr-1 expression at the protein level . Negative_regulation EPHB2 MAPK11 17615677 1769056 We conclude that [ERK] activation and p38 *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation EPHB2 MAPK11 19428337 2077000 Histological examination of lung tissues revealed that [ERK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation EPHB2 MAPK11 21323644 2447666 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) [/ERK] signalling . Negative_regulation EPHB2 MAPK11 21663947 2459745 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation EPHB2 MAPK11 22129743 2515076 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 and Akt phosphorylation , but in contrast , *inhibited* that of [ERK] ( 1/2 ) . Negative_regulation EPHB2 MAPK11 23524336 2777310 tMEK is a novel output from the canonical MAP kinase signalling pathway , acting in a signalling regulated dominant negative manner to *inhibit* [ERK] and p90RSK activations , acting as a dampening mechanism to reduce the magnitude or duration of MAPK pathway signalling in G2/M phase . Negative_regulation EPHB2 MAPK12 12419320 1013193 Inhibition of p38 *stimulated* Raf and [ERK] activities , and induced cell proliferation in differentiation medium . Negative_regulation EPHB2 MAPK12 15610507 1348261 The heat shock induced MMP-1 and MMP-3 expression was suppressed by the inhibition of [ERK] and JNK but not by p38 *inhibition* . Negative_regulation EPHB2 MAPK12 15640153 1381282 MMP-1 secretion required activation of the MAPK [Erk] and subsequent protein synthesis but was *down-regulated* by the alternate , p38 . Negative_regulation EPHB2 MAPK12 15810889 1392153 Thus , [ERK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation EPHB2 MAPK12 16291589 1525993 TCCM treatment activated p38 and Janus kinase (JNK) but *inhibited* [extracellular regulated kinase (ERK)] . Negative_regulation EPHB2 MAPK12 16291589 1526024 Thus , our results suggested that tumor induced p38 activation and [ERK] *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation EPHB2 MAPK12 16464862 1548089 In contrast , p38 inhibitors *had* no detectable effect on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Negative_regulation EPHB2 MAPK12 17065146 1654689 *Inhibitors* of [ERK] and JNK ( but not of p38 ) reduced egr-1 expression at the protein level . Negative_regulation EPHB2 MAPK12 17615677 1769057 We conclude that [ERK] activation and p38 *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation EPHB2 MAPK12 19428337 2077001 Histological examination of lung tissues revealed that [ERK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation EPHB2 MAPK12 21323644 2447667 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) [/ERK] signalling . Negative_regulation EPHB2 MAPK12 21663947 2459746 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation EPHB2 MAPK12 22129743 2515077 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 and Akt phosphorylation , but in contrast , *inhibited* that of [ERK] ( 1/2 ) . Negative_regulation EPHB2 MAPK12 23524336 2777311 tMEK is a novel output from the canonical MAP kinase signalling pathway , acting in a signalling regulated dominant negative manner to *inhibit* [ERK] and p90RSK activations , acting as a dampening mechanism to reduce the magnitude or duration of MAPK pathway signalling in G2/M phase . Negative_regulation EPHB2 MAPK13 12419320 1013194 Inhibition of p38 *stimulated* Raf and [ERK] activities , and induced cell proliferation in differentiation medium . Negative_regulation EPHB2 MAPK13 15610507 1348262 The heat shock induced MMP-1 and MMP-3 expression was suppressed by the inhibition of [ERK] and JNK but not by p38 *inhibition* . Negative_regulation EPHB2 MAPK13 15640153 1381283 MMP-1 secretion required activation of the MAPK [Erk] and subsequent protein synthesis but was *down-regulated* by the alternate , p38 . Negative_regulation EPHB2 MAPK13 15810889 1392154 Thus , [ERK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation EPHB2 MAPK13 16291589 1525994 TCCM treatment activated p38 and Janus kinase (JNK) but *inhibited* [extracellular regulated kinase (ERK)] . Negative_regulation EPHB2 MAPK13 16291589 1526025 Thus , our results suggested that tumor induced p38 activation and [ERK] *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation EPHB2 MAPK13 16464862 1548090 In contrast , p38 inhibitors *had* no detectable effect on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Negative_regulation EPHB2 MAPK13 17065146 1654690 *Inhibitors* of [ERK] and JNK ( but not of p38 ) reduced egr-1 expression at the protein level . Negative_regulation EPHB2 MAPK13 17615677 1769058 We conclude that [ERK] activation and p38 *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation EPHB2 MAPK13 19428337 2077002 Histological examination of lung tissues revealed that [ERK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation EPHB2 MAPK13 21323644 2447668 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) [/ERK] signalling . Negative_regulation EPHB2 MAPK13 21663947 2459747 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation EPHB2 MAPK13 22129743 2515078 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 and Akt phosphorylation , but in contrast , *inhibited* that of [ERK] ( 1/2 ) . Negative_regulation EPHB2 MAPK13 23524336 2777312 tMEK is a novel output from the canonical MAP kinase signalling pathway , acting in a signalling regulated dominant negative manner to *inhibit* [ERK] and p90RSK activations , acting as a dampening mechanism to reduce the magnitude or duration of MAPK pathway signalling in G2/M phase . Negative_regulation EPHB2 MAPK14 12419320 1013195 Inhibition of p38 *stimulated* Raf and [ERK] activities , and induced cell proliferation in differentiation medium . Negative_regulation EPHB2 MAPK14 15610507 1348263 The heat shock induced MMP-1 and MMP-3 expression was suppressed by the inhibition of [ERK] and JNK but not by p38 *inhibition* . Negative_regulation EPHB2 MAPK14 15640153 1381284 MMP-1 secretion required activation of the MAPK [Erk] and subsequent protein synthesis but was *down-regulated* by the alternate , p38 . Negative_regulation EPHB2 MAPK14 15810889 1392155 Thus , [ERK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation EPHB2 MAPK14 16291589 1525995 TCCM treatment activated p38 and Janus kinase (JNK) but *inhibited* [extracellular regulated kinase (ERK)] . Negative_regulation EPHB2 MAPK14 16291589 1526026 Thus , our results suggested that tumor induced p38 activation and [ERK] *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation EPHB2 MAPK14 16464862 1548091 In contrast , p38 inhibitors *had* no detectable effect on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Negative_regulation EPHB2 MAPK14 17065146 1654691 *Inhibitors* of [ERK] and JNK ( but not of p38 ) reduced egr-1 expression at the protein level . Negative_regulation EPHB2 MAPK14 17615677 1769059 We conclude that [ERK] activation and p38 *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation EPHB2 MAPK14 19428337 2077003 Histological examination of lung tissues revealed that [ERK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation EPHB2 MAPK14 21323644 2447669 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) [/ERK] signalling . Negative_regulation EPHB2 MAPK14 21663947 2459748 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation EPHB2 MAPK14 22129743 2515079 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 and Akt phosphorylation , but in contrast , *inhibited* that of [ERK] ( 1/2 ) . Negative_regulation EPHB2 MAPK14 23524336 2777313 tMEK is a novel output from the canonical MAP kinase signalling pathway , acting in a signalling regulated dominant negative manner to *inhibit* [ERK] and p90RSK activations , acting as a dampening mechanism to reduce the magnitude or duration of MAPK pathway signalling in G2/M phase . Negative_regulation EPHB2 MAPK15 12419320 1013189 Inhibition of p38 *stimulated* Raf and [ERK] activities , and induced cell proliferation in differentiation medium . Negative_regulation EPHB2 MAPK15 15610507 1348256 The heat shock induced MMP-1 and MMP-3 expression was suppressed by the inhibition of [ERK] and JNK but not by p38 *inhibition* . Negative_regulation EPHB2 MAPK15 15640153 1381278 MMP-1 secretion required activation of the MAPK [Erk] and subsequent protein synthesis but was *down-regulated* by the alternate , p38 . Negative_regulation EPHB2 MAPK15 15810889 1392149 Thus , [ERK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation EPHB2 MAPK15 16291589 1525986 TCCM treatment activated p38 and Janus kinase (JNK) but *inhibited* [extracellular regulated kinase (ERK)] . Negative_regulation EPHB2 MAPK15 16291589 1526020 Thus , our results suggested that tumor induced p38 activation and [ERK] *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation EPHB2 MAPK15 16464862 1548084 In contrast , p38 inhibitors *had* no detectable effect on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Negative_regulation EPHB2 MAPK15 17065146 1654685 *Inhibitors* of [ERK] and JNK ( but not of p38 ) reduced egr-1 expression at the protein level . Negative_regulation EPHB2 MAPK15 17615677 1769053 We conclude that [ERK] activation and p38 *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation EPHB2 MAPK15 19428337 2076997 Histological examination of lung tissues revealed that [ERK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation EPHB2 MAPK15 21323644 2447663 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) [/ERK] signalling . Negative_regulation EPHB2 MAPK15 21663947 2459741 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation EPHB2 MAPK15 22129743 2515070 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 and Akt phosphorylation , but in contrast , *inhibited* that of [ERK] ( 1/2 ) . Negative_regulation EPHB2 MAPK15 23524336 2777307 tMEK is a novel output from the canonical MAP kinase signalling pathway , acting in a signalling regulated dominant negative manner to *inhibit* [ERK] and p90RSK activations , acting as a dampening mechanism to reduce the magnitude or duration of MAPK pathway signalling in G2/M phase . Negative_regulation EPHB2 MAPK3 11777902 916392 These data demonstrate that beta-arrestins facilitate GPCR mediated [ERK] activation but *inhibit* ERK dependent transcription by binding to , leading to its retention in the cytosol . Negative_regulation EPHB2 MAPK3 12419320 1013196 Inhibition of p38 *stimulated* Raf and [ERK] activities , and induced cell proliferation in differentiation medium . Negative_regulation EPHB2 MAPK3 15610507 1348264 The heat shock induced MMP-1 and MMP-3 expression was suppressed by the inhibition of [ERK] and JNK but not by p38 *inhibition* . Negative_regulation EPHB2 MAPK3 15640153 1381285 MMP-1 secretion required activation of the MAPK [Erk] and subsequent protein synthesis but was *down-regulated* by the alternate , p38 . Negative_regulation EPHB2 MAPK3 15810889 1392156 Thus , [ERK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation EPHB2 MAPK3 16291589 1525996 TCCM treatment activated p38 and Janus kinase (JNK) but *inhibited* [extracellular regulated kinase (ERK)] . Negative_regulation EPHB2 MAPK3 16291589 1526027 Thus , our results suggested that tumor induced p38 activation and [ERK] *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation EPHB2 MAPK3 16464862 1548092 In contrast , p38 inhibitors *had* no detectable effect on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Negative_regulation EPHB2 MAPK3 16644694 1553151 Conversely , Ex-4 *induced* [extracellular regulated kinase (ERK)] 1/2 activation in PL 45 cells in a GLP-1R-and epidermal growth factor receptor dependent manner , whereas Ex-4 inhibited phosphorylation in Hs 766T and CAPAN-1 cells . Negative_regulation EPHB2 MAPK3 17065146 1654692 *Inhibitors* of [ERK] and JNK ( but not of p38 ) reduced egr-1 expression at the protein level . Negative_regulation EPHB2 MAPK3 17492827 1744370 Examination of potential signalling pathways revealed that FIZZ1 induced rapid phosphorylation of , while PD98059 , a [MEK/ERK] *inhibitor* , markedly induced activation of caspase-3 . Negative_regulation EPHB2 MAPK3 17615677 1769060 We conclude that [ERK] activation and p38 *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation EPHB2 MAPK3 19428337 2077004 Histological examination of lung tissues revealed that [ERK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation EPHB2 MAPK3 21323644 2447670 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) [/ERK] signalling . Negative_regulation EPHB2 MAPK3 21663947 2459749 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation EPHB2 MAPK3 22129743 2515080 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 and Akt phosphorylation , but in contrast , *inhibited* that of [ERK] ( 1/2 ) . Negative_regulation EPHB2 MAPK3 23416149 2759869 COA-Cl increased [phospho-ERK] levels in a dose dependent manner and COA-Cl induced neuroprotection and activation was *inhibited* by suramin or PD98059 . Negative_regulation EPHB2 MAPK3 23524336 2777314 tMEK is a novel output from the canonical MAP kinase signalling pathway , acting in a signalling regulated dominant negative manner to *inhibit* [ERK] and p90RSK activations , acting as a dampening mechanism to reduce the magnitude or duration of MAPK pathway signalling in G2/M phase . Negative_regulation EPHB2 MAPK4 12419320 1013197 Inhibition of p38 *stimulated* Raf and [ERK] activities , and induced cell proliferation in differentiation medium . Negative_regulation EPHB2 MAPK4 15610507 1348265 The heat shock induced MMP-1 and MMP-3 expression was suppressed by the inhibition of [ERK] and JNK but not by p38 *inhibition* . Negative_regulation EPHB2 MAPK4 15640153 1381286 MMP-1 secretion required activation of the MAPK [Erk] and subsequent protein synthesis but was *down-regulated* by the alternate , p38 . Negative_regulation EPHB2 MAPK4 15810889 1392157 Thus , [ERK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation EPHB2 MAPK4 16291589 1525997 TCCM treatment activated p38 and Janus kinase (JNK) but *inhibited* [extracellular regulated kinase (ERK)] . Negative_regulation EPHB2 MAPK4 16291589 1526028 Thus , our results suggested that tumor induced p38 activation and [ERK] *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation EPHB2 MAPK4 16464862 1548093 In contrast , p38 inhibitors *had* no detectable effect on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Negative_regulation EPHB2 MAPK4 17065146 1654693 *Inhibitors* of [ERK] and JNK ( but not of p38 ) reduced egr-1 expression at the protein level . Negative_regulation EPHB2 MAPK4 17615677 1769061 We conclude that [ERK] activation and p38 *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation EPHB2 MAPK4 19428337 2077005 Histological examination of lung tissues revealed that [ERK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation EPHB2 MAPK4 21323644 2447671 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) [/ERK] signalling . Negative_regulation EPHB2 MAPK4 21663947 2459750 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation EPHB2 MAPK4 22129743 2515081 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 and Akt phosphorylation , but in contrast , *inhibited* that of [ERK] ( 1/2 ) . Negative_regulation EPHB2 MAPK4 23524336 2777315 tMEK is a novel output from the canonical MAP kinase signalling pathway , acting in a signalling regulated dominant negative manner to *inhibit* [ERK] and p90RSK activations , acting as a dampening mechanism to reduce the magnitude or duration of MAPK pathway signalling in G2/M phase . Negative_regulation EPHB2 MAPK6 12419320 1013198 Inhibition of p38 *stimulated* Raf and [ERK] activities , and induced cell proliferation in differentiation medium . Negative_regulation EPHB2 MAPK6 15610507 1348266 The heat shock induced MMP-1 and MMP-3 expression was suppressed by the inhibition of [ERK] and JNK but not by p38 *inhibition* . Negative_regulation EPHB2 MAPK6 15640153 1381287 MMP-1 secretion required activation of the MAPK [Erk] and subsequent protein synthesis but was *down-regulated* by the alternate , p38 . Negative_regulation EPHB2 MAPK6 15810889 1392158 Thus , [ERK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation EPHB2 MAPK6 16291589 1525998 TCCM treatment activated p38 and Janus kinase (JNK) but *inhibited* [extracellular regulated kinase (ERK)] . Negative_regulation EPHB2 MAPK6 16291589 1526029 Thus , our results suggested that tumor induced p38 activation and [ERK] *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation EPHB2 MAPK6 16464862 1548094 In contrast , p38 inhibitors *had* no detectable effect on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Negative_regulation EPHB2 MAPK6 17065146 1654694 *Inhibitors* of [ERK] and JNK ( but not of p38 ) reduced egr-1 expression at the protein level . Negative_regulation EPHB2 MAPK6 17615677 1769062 We conclude that [ERK] activation and p38 *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation EPHB2 MAPK6 19428337 2077006 Histological examination of lung tissues revealed that [ERK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation EPHB2 MAPK6 21323644 2447672 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) [/ERK] signalling . Negative_regulation EPHB2 MAPK6 21663947 2459751 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation EPHB2 MAPK6 22129743 2515082 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 and Akt phosphorylation , but in contrast , *inhibited* that of [ERK] ( 1/2 ) . Negative_regulation EPHB2 MAPK6 23524336 2777316 tMEK is a novel output from the canonical MAP kinase signalling pathway , acting in a signalling regulated dominant negative manner to *inhibit* [ERK] and p90RSK activations , acting as a dampening mechanism to reduce the magnitude or duration of MAPK pathway signalling in G2/M phase . Negative_regulation EPHB2 MAPK7 12419320 1013199 Inhibition of p38 *stimulated* Raf and [ERK] activities , and induced cell proliferation in differentiation medium . Negative_regulation EPHB2 MAPK7 15610507 1348267 The heat shock induced MMP-1 and MMP-3 expression was suppressed by the inhibition of [ERK] and JNK but not by p38 *inhibition* . Negative_regulation EPHB2 MAPK7 15640153 1381288 MMP-1 secretion required activation of the MAPK [Erk] and subsequent protein synthesis but was *down-regulated* by the alternate , p38 . Negative_regulation EPHB2 MAPK7 15810889 1392159 Thus , [ERK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation EPHB2 MAPK7 16291589 1525999 TCCM treatment activated p38 and Janus kinase (JNK) but *inhibited* [extracellular regulated kinase (ERK)] . Negative_regulation EPHB2 MAPK7 16291589 1526030 Thus , our results suggested that tumor induced p38 activation and [ERK] *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation EPHB2 MAPK7 16464862 1548095 In contrast , p38 inhibitors *had* no detectable effect on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Negative_regulation EPHB2 MAPK7 17065146 1654695 *Inhibitors* of [ERK] and JNK ( but not of p38 ) reduced egr-1 expression at the protein level . Negative_regulation EPHB2 MAPK7 17615677 1769063 We conclude that [ERK] activation and p38 *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation EPHB2 MAPK7 19428337 2077007 Histological examination of lung tissues revealed that [ERK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation EPHB2 MAPK7 21323644 2447673 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) [/ERK] signalling . Negative_regulation EPHB2 MAPK7 21663947 2459752 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation EPHB2 MAPK7 22129743 2515083 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 and Akt phosphorylation , but in contrast , *inhibited* that of [ERK] ( 1/2 ) . Negative_regulation EPHB2 MAPK7 23524336 2777317 tMEK is a novel output from the canonical MAP kinase signalling pathway , acting in a signalling regulated dominant negative manner to *inhibit* [ERK] and p90RSK activations , acting as a dampening mechanism to reduce the magnitude or duration of MAPK pathway signalling in G2/M phase . Negative_regulation EPHB2 MAPK8 12419320 1013200 Inhibition of p38 *stimulated* Raf and [ERK] activities , and induced cell proliferation in differentiation medium . Negative_regulation EPHB2 MAPK8 15610507 1348268 The heat shock induced MMP-1 and MMP-3 expression was suppressed by the inhibition of [ERK] and JNK but not by p38 *inhibition* . Negative_regulation EPHB2 MAPK8 15640153 1381289 MMP-1 secretion required activation of the MAPK [Erk] and subsequent protein synthesis but was *down-regulated* by the alternate , p38 . Negative_regulation EPHB2 MAPK8 15810889 1392160 Thus , [ERK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation EPHB2 MAPK8 16291589 1526000 TCCM treatment activated p38 and Janus kinase (JNK) but *inhibited* [extracellular regulated kinase (ERK)] . Negative_regulation EPHB2 MAPK8 16291589 1526031 Thus , our results suggested that tumor induced p38 activation and [ERK] *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation EPHB2 MAPK8 16464862 1548096 In contrast , p38 inhibitors *had* no detectable effect on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Negative_regulation EPHB2 MAPK8 17065146 1654696 *Inhibitors* of [ERK] and JNK ( but not of p38 ) reduced egr-1 expression at the protein level . Negative_regulation EPHB2 MAPK8 17615677 1769064 We conclude that [ERK] activation and p38 *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation EPHB2 MAPK8 17637226 1770764 it also promoted the activation of [p-ERK] during the early phase of reperfusion but *inhibited* the activation of and p-p38 following the 30-minute , 1-hour and 3-hour intervals of reperfusion . Negative_regulation EPHB2 MAPK8 19428337 2077008 Histological examination of lung tissues revealed that [ERK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation EPHB2 MAPK8 21323644 2447674 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) [/ERK] signalling . Negative_regulation EPHB2 MAPK8 21663947 2459753 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation EPHB2 MAPK8 22129743 2515084 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 and Akt phosphorylation , but in contrast , *inhibited* that of [ERK] ( 1/2 ) . Negative_regulation EPHB2 MAPK8 23524336 2777318 tMEK is a novel output from the canonical MAP kinase signalling pathway , acting in a signalling regulated dominant negative manner to *inhibit* [ERK] and p90RSK activations , acting as a dampening mechanism to reduce the magnitude or duration of MAPK pathway signalling in G2/M phase . Negative_regulation EPHB2 MAPK9 12419320 1013201 Inhibition of p38 *stimulated* Raf and [ERK] activities , and induced cell proliferation in differentiation medium . Negative_regulation EPHB2 MAPK9 15610507 1348269 The heat shock induced MMP-1 and MMP-3 expression was suppressed by the inhibition of [ERK] and JNK but not by p38 *inhibition* . Negative_regulation EPHB2 MAPK9 15640153 1381290 MMP-1 secretion required activation of the MAPK [Erk] and subsequent protein synthesis but was *down-regulated* by the alternate , p38 . Negative_regulation EPHB2 MAPK9 15810889 1392161 Thus , [ERK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation EPHB2 MAPK9 16291589 1526001 TCCM treatment activated p38 and Janus kinase (JNK) but *inhibited* [extracellular regulated kinase (ERK)] . Negative_regulation EPHB2 MAPK9 16291589 1526032 Thus , our results suggested that tumor induced p38 activation and [ERK] *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation EPHB2 MAPK9 16464862 1548097 In contrast , p38 inhibitors *had* no detectable effect on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Negative_regulation EPHB2 MAPK9 17065146 1654697 *Inhibitors* of [ERK] and JNK ( but not of p38 ) reduced egr-1 expression at the protein level . Negative_regulation EPHB2 MAPK9 17615677 1769065 We conclude that [ERK] activation and p38 *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation EPHB2 MAPK9 19428337 2077009 Histological examination of lung tissues revealed that [ERK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation EPHB2 MAPK9 21323644 2447675 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) [/ERK] signalling . Negative_regulation EPHB2 MAPK9 21663947 2459754 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation EPHB2 MAPK9 22129743 2515085 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 and Akt phosphorylation , but in contrast , *inhibited* that of [ERK] ( 1/2 ) . Negative_regulation EPHB2 MAPK9 23524336 2777319 tMEK is a novel output from the canonical MAP kinase signalling pathway , acting in a signalling regulated dominant negative manner to *inhibit* [ERK] and p90RSK activations , acting as a dampening mechanism to reduce the magnitude or duration of MAPK pathway signalling in G2/M phase . Negative_regulation EPHB2 MAPKAP1 20512842 2270544 In this report , we focused on studying the *role* of mTORC1 and in rapamycin mediated Akt and [ERK] phosphorylation , and the antitumor effect of rapamycin in cancer cells in combination with Akt and ERK inhibitors . Negative_regulation EPHB2 MAX 23592794 2773258 In this study , we define a mechanism for this by showing that complexes *suppress* [ERK] activity by transcriptionally regulating two members of the dual-specificity phosphatase (DUSP) family . Negative_regulation EPHB2 MBTPS1 12443721 1017211 Inhibition of ras with MA and PI3-K with Wn also reduced [ERK] phosphorylation and smooth muscle cell migration in *response* to . Negative_regulation EPHB2 MBTPS1 14742298 1242747 activated Akt and ERK within minutes , and inhibition of sphingosine kinase *blocked* RSV induced [ERK] and Akt activation , leading to accelerated cell death after viral infection . Negative_regulation EPHB2 MBTPS1 18171908 1883120 significantly *inhibited* IL-1beta induced persistent activation of extracellular signal regulated kinase ( [ERK] ) but had no effect in Ca ( 2+ ) -depleted conditions . Negative_regulation EPHB2 MBTPS1 19433984 2096501 Treatment with the nonselective S1P receptor agonist FTY720 for 1 hour also reduced [phospho-ERK] expression in *response* to subsequent stimulation . Negative_regulation EPHB2 MCL1 21598425 2430808 O. japonicus down-regulated protein levels and *inhibited* the phosphorylation of [MEK/ERK] , suggesting that it mediates cell death in LX2 cells through the down-regulation of Mcl-1 protein via a MEK/ERK independent pathway . Negative_regulation EPHB2 MCL1 23741975 2909179 Combined treatment with rapamycin and IDA down-regulated Bcl-2 and , and *inhibited* the activation of phosphoinositide 3-kinase (PI3K)/mTOR and extracellular signal related kinase ( [ERK] ) . Negative_regulation EPHB2 MCTS1 17416211 1777831 While gene knockdown or [MEK/ERK] pathway *inhibition* dramatically reduced MAPK phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Negative_regulation EPHB2 MET 23318428 2860722 Expression of with Tyr542/580Phe mutations *resulted* in the suppression of [Erk] activation . Negative_regulation EPHB2 MET 24102522 2852483 Activation of [ERK-p53] was also detected in autophagy process and could be *augmented* by inhibition of . Negative_regulation EPHB2 MGAT3 11134020 794905 Overexpression of *enhances* the epidermal growth factor induced phosphorylation of [ERK] in HeLaS3 cells by up-regulation of the internalization rate of the receptors . Negative_regulation EPHB2 MGAT3 11134020 794912 These results suggest that overexpression in HeLaS3 cells *resulted* in an enhancement of EGF induced [ERK] phosphorylation at least in part by the up-regulation of the endocytosis of EGFR . Negative_regulation EPHB2 MIA 20164682 2242595 Active ERK signaling is known to block chondrogenic differentiation and we revealed induction of aggrecan expression in chondrocytes by treatment with or PD098059 , an [ERK] *inhibitor* . Negative_regulation EPHB2 MIF 18821572 1993591 To understand the *role* of secretion in thrombin induced biphasic activation of [ERK] ( 1/2 ) , BPAE cells were treated with ( i ) recombinant MIF , and ( ii ) the medium collected from thrombin treated BPAE cells . Negative_regulation EPHB2 MLST8 20512842 2270545 In this report , we focused on studying the *role* of mTORC1 and in rapamycin mediated Akt and [ERK] phosphorylation , and the antitumor effect of rapamycin in cancer cells in combination with Akt and ERK inhibitors . Negative_regulation EPHB2 MLST8 22715163 2634055 Lovastatin alone significantly reduced MPC and MTT cell viability at therapeutically relevant doses and *inhibited* both [ERK] and AKT signalling , but increased signalling . Negative_regulation EPHB2 MMAB 17644731 1798831 This study was undertaken to elucidate the mechanisms underlying *induced* PI3K/Akt and [ERK] inhibition and the inability of IL-6 and IGF-I to protect myeloma cells from mAb induced apoptosis . Negative_regulation EPHB2 MMD 21968647 2574472 Overexpression of stimulates basal and EGF induced ERK phosphorylation and *increases* the expression of [ERK] target genes in a dose dependent manner . Negative_regulation EPHB2 MMD2 21968647 2574471 Overexpression of stimulates basal and EGF induced ERK phosphorylation and *increases* the expression of [ERK] target genes in a dose dependent manner . Negative_regulation EPHB2 MMP1 14634122 1170902 Addition of exogenous PGE ( 1 ) or PGE ( 2 ) inhibited , reversed the effects of COX inhibitors , and *inhibited* [ERK] activation , suggesting that COX-2 activity tonically inhibits MMP-1 production via ERK inhibition by E PGs . Negative_regulation EPHB2 MMP1 15640153 1381323 PGEs enhanced [Erk] activation and MMP-1 secretion in response to EGF but *inhibited* Erk and when TNF-alpha and IL-1beta were the stimuli , indicating that the effects of PGEs on gastric cell responses are context dependent . Negative_regulation EPHB2 MMP1 15930517 1433896 Pretreatment of HDFs with EPA inhibited UV-induced expression in a dose dependent manner and also *inhibited* the UV-induced activation of [ERK] and JNK by inhibiting ERK kinase ( MEK1 ) and SAPK/ERK kinase 1 (SEK1) activation , respectively . Negative_regulation EPHB2 MMP1 16101130 1444140 R115777 +/- paclitaxel inhibited HDJ-2 farnesylation , up-regulated RhoB , transiently lowered ( P ) [ERK/ERK] and ( P ) Akt/Akt , reduced Raf-1 and MEK and *inhibited* secretion of VEGF and . Negative_regulation EPHB2 MMP1 16413539 1514341 Pretreatment of HSFs with 2',4',7-THF inhibited UV-induced expression in a dose dependent manner , and also *inhibited* the UV-induced activations of [ERK] and JNK by inhibiting MEK1 and SEK1 activation , respectively . Negative_regulation EPHB2 MMP1 21056074 2370800 The results showed that CAE stimulated type I procollagen expression , inhibited , -3 , -9 expression and *inhibited* the phosphorylation of JNK , [ERK] and p38 . Negative_regulation EPHB2 MMP9 19299917 2064154 A chemical inhibitor of MEK1/2 or PI3K reduced phosphorylation of [ERK] or Akt , respectively , and also *inhibited* CSE mediated induction . Negative_regulation EPHB2 MOK 12962137 1138502 These results indicate that , in phenotypically mature osteoblastic cells , changes in [ERK] activation closely *follow* the AGEs induced regulation of expression . Negative_regulation EPHB2 MPG 21907719 2501449 Moreover , NADPH oxidase inhibition or antioxidant *prevented* both A ( 1 ) AR-mediated arrhythmias and [ERK] phosphorylation . Negative_regulation EPHB2 MRE11A 10476970 642772 This decrease in GTP bound *activates* [ERK/MAPK] . Negative_regulation EPHB2 MRE11A 11228165 788457 Furthermore , overexpression of *enhanced* p38 activity but not [ERK] or JNK activity . Negative_regulation EPHB2 MRE11A 11340161 812419 In NIH 3T3 cells , is *required* not only for cAMP 's inhibition of [ERK] activation but for inhibition of cell proliferation and mitogenesis as well . Negative_regulation EPHB2 MRE11A 11479306 860615 Moreover , inhibition of by a Rap1 GTPase activating protein-1 also *resulted* in a decrease in [ERK] and Akt phosphorylation , which was not further decreased by cAMP , suggesting that cAMP inhibits ERK and Akt by inhibiting Rap1 . Negative_regulation EPHB2 MRE11A 11479306 860671 The *role* of in [ERK] and Akt activity was further demonstrated by our observation that an active form of Epac , which activated Rap1 in the absence of cAMP , increased ERK and Akt phosphorylation . Negative_regulation EPHB2 MRE11A 16507992 1529664 We confirm that the PKA independent activation of by Epac1 activates a perinuclear pool of Rap1 and that this does not *result* in [ERK] activation . Negative_regulation EPHB2 MTOR 19539245 2099080 Investigation of this hypothesis in a TSC cell model revealed that suppression with an mTOR inhibitor , rapamycin ( sirolimus ) , *led* to up-regulation of [ERK/MAPK] signaling in mouse Tsc2 knockout cells and that this augmented signaling was attenuated by concurrent administration of a MEK1/2 inhibitor , PD98059 . Negative_regulation EPHB2 MTOR 20512842 2270548 In this report , we focused on studying the *role* of and mTORC2 in rapamycin mediated Akt and [ERK] phosphorylation , and the antitumor effect of rapamycin in cancer cells in combination with Akt and ERK inhibitors . Negative_regulation EPHB2 MTOR 21494688 2418134 Morphoproteomic analysis revealed that the mTOR pathway was activated in these two patients with advanced Ewing 's sarcoma who showed response to combined IGF1R and *inhibition* , and the [ERK] pathway in the patient in whom resistance to this combination emerged . Negative_regulation EPHB2 MTOR 22715163 2634057 Lovastatin alone significantly reduced MPC and MTT cell viability at therapeutically relevant doses and *inhibited* both [ERK] and AKT signalling , but increased signalling . Negative_regulation EPHB2 MTOR 23437362 2744609 Conversely , active-site inhibitors of *cause* a marked increase in [ERK] activation whereas rapamycin did not have any stimulatory effect on ERK activation . Negative_regulation EPHB2 MUC1 15162440 1253016 Furthermore , AgC10 inhibition must lie upstream in the MAPK activation pathway by LPS , since this also *inhibited* [extracellularly regulated kinase (ERK)] and Jun kinase (JNK)activation . Negative_regulation EPHB2 MUC1 22457794 2578442 Suppression of expression *resulted* in EGFR destabilization and inhibition of the BPDE induced activation of Akt and [ERK] and increase of cytotoxicity . Negative_regulation EPHB2 MUC1 24043631 2857345 In studies of breast cancer cells stably silenced for MUC1 or overexpressing the oncogenic MUC1-C subunit , we demonstrate that is sufficient for induction of MEK ? ERK signaling and that treatment with a MUC1-C inhibitor *suppresses* [ERK] activation . Negative_regulation EPHB2 MUC12 15162440 1253017 Furthermore , AgC10 inhibition must lie upstream in the MAPK activation pathway by LPS , since this also *inhibited* [extracellularly regulated kinase (ERK)] and Jun kinase (JNK)activation . Negative_regulation EPHB2 MUC13 15162440 1253018 Furthermore , AgC10 inhibition must lie upstream in the MAPK activation pathway by LPS , since this also *inhibited* [extracellularly regulated kinase (ERK)] and Jun kinase (JNK)activation . Negative_regulation EPHB2 MUC13 22027689 2533786 Conversely , suppression of in HPAFII pancreatic cancer cells by short hairpin RNA *resulted* in suppression of tumorigenic characteristics , repression of HER2 , PAK1 , [ERK] , and S100A4 , and upregulation of p53 . Negative_regulation EPHB2 MUC15 15162440 1253010 Furthermore , AgC10 inhibition must lie upstream in the MAPK activation pathway by LPS , since this also *inhibited* [extracellularly regulated kinase (ERK)] and Jun kinase (JNK)activation . Negative_regulation EPHB2 MUC16 15162440 1253011 Furthermore , AgC10 inhibition must lie upstream in the MAPK activation pathway by LPS , since this also *inhibited* [extracellularly regulated kinase (ERK)] and Jun kinase (JNK)activation . Negative_regulation EPHB2 MUC17 15162440 1253012 Furthermore , AgC10 inhibition must lie upstream in the MAPK activation pathway by LPS , since this also *inhibited* [extracellularly regulated kinase (ERK)] and Jun kinase (JNK)activation . Negative_regulation EPHB2 MUC19 15162440 1253009 Furthermore , AgC10 inhibition must lie upstream in the MAPK activation pathway by LPS , since this also *inhibited* [extracellularly regulated kinase (ERK)] and Jun kinase (JNK)activation . Negative_regulation EPHB2 MUC2 15162440 1253019 Furthermore , AgC10 inhibition must lie upstream in the MAPK activation pathway by LPS , since this also *inhibited* [extracellularly regulated kinase (ERK)] and Jun kinase (JNK)activation . Negative_regulation EPHB2 MUC20 15162440 1253014 Furthermore , AgC10 inhibition must lie upstream in the MAPK activation pathway by LPS , since this also *inhibited* [extracellularly regulated kinase (ERK)] and Jun kinase (JNK)activation . Negative_regulation EPHB2 MUC21 15162440 1253013 Furthermore , AgC10 inhibition must lie upstream in the MAPK activation pathway by LPS , since this also *inhibited* [extracellularly regulated kinase (ERK)] and Jun kinase (JNK)activation . Negative_regulation EPHB2 MUC22 15162440 1253015 Furthermore , AgC10 inhibition must lie upstream in the MAPK activation pathway by LPS , since this also *inhibited* [extracellularly regulated kinase (ERK)] and Jun kinase (JNK)activation . Negative_regulation EPHB2 MUC4 15162440 1253020 Furthermore , AgC10 inhibition must lie upstream in the MAPK activation pathway by LPS , since this also *inhibited* [extracellularly regulated kinase (ERK)] and Jun kinase (JNK)activation . Negative_regulation EPHB2 MUC6 15162440 1253021 Furthermore , AgC10 inhibition must lie upstream in the MAPK activation pathway by LPS , since this also *inhibited* [extracellularly regulated kinase (ERK)] and Jun kinase (JNK)activation . Negative_regulation EPHB2 MUC7 15162440 1253022 Furthermore , AgC10 inhibition must lie upstream in the MAPK activation pathway by LPS , since this also *inhibited* [extracellularly regulated kinase (ERK)] and Jun kinase (JNK)activation . Negative_regulation EPHB2 MUC8 15162440 1253023 Furthermore , AgC10 inhibition must lie upstream in the MAPK activation pathway by LPS , since this also *inhibited* [extracellularly regulated kinase (ERK)] and Jun kinase (JNK)activation . Negative_regulation EPHB2 MYC 23592794 2773259 In this study , we define a mechanism for this by showing that complexes *suppress* [ERK] activity by transcriptionally regulating two members of the dual-specificity phosphatase (DUSP) family . Negative_regulation EPHB2 MYD88 22743248 2644397 Our flow cytometry and Western blot data showed that paclitaxel activated [TLR4-MyD88-ERK] signaling and that IS treatment could effectively *inhibit* this paclitaxel induced activation of signaling . Negative_regulation EPHB2 MYLIP 22102825 2509464 Ectopic expression *reduced* basal [ERK] and AKT phosphorylation and enhanced sensitivity to serum growth factor withdrawal , while cells genetically deficient in miR-34a were less sensitive . Negative_regulation EPHB2 MYLIP 22387281 2587479 Further , downregulated miR-21 expression and *prevented* the arsenite induced activation of [ERK] via the increase in Spry1 , indicating that miR-21 has a feedback effect in regulating ERK activation . Negative_regulation EPHB2 MYLIP 22580051 2609651 The [IGF-IR/MEK/ERK] signaling was *inhibited* by overexpression and then resulted in MMP-2 promoter suppression . Negative_regulation EPHB2 MYLIP 22644326 2658924 Further study showed that phosphorylation of [ERK] ( 1/2 ) and AKT was *suppressed* by overexpressing , whereas the suppressed MAPK and AKT signaling could be recovered by anti-miR-125a treatment . Negative_regulation EPHB2 MYLIP 24009080 2851433 Ectopic *resulted* in a decrease in [Erk] signaling and transformation , which was dependent on the down-regulation of c-Kit expression . Negative_regulation EPHB2 MYLIP 24167656 2860116 We also show that expression *suppressed* [ERK] phosphorylation and MMP-9 expression in glioma cells . Negative_regulation EPHB2 NA 11940570 953496 In contrast , *reduced* [ERK] activity to 60 % and decreased p38 activity to the basal level , but JNK activity was induced 2-fold . Negative_regulation EPHB2 NA 15203191 1261056 TGF-beta stimulated [ERK] and JNK phosphorylation was also *inhibited* by . Negative_regulation EPHB2 NA 15965078 1423462 These findings demonstrate that *blocks* the NGF induced [H2O2/ERK] signaling in PC12 cells . Negative_regulation EPHB2 NA 15982852 1497991 The antioxidant *inhibited* IL-3 induced tyrosine phosphorylation of Jak2 , IL-3 receptor betac subunit ( IL-3Rbetac ) , and STAT5 as well as activation-specific phosphorylation of Akt , MEK , and [ERK] , while treatment of cells with H2O2 activated these signaling events . Negative_regulation EPHB2 NA 16473382 1581747 Neither nor DTT *blocked* the phosphorylation of [ERK] suggesting that this activation is not related to oxidative stress . Negative_regulation EPHB2 NA 20402656 2246002 [ERK] activation was *inhibited* by PD98059 , Wortmanin and the ROS scavenger ( N-acetyl cysteine ) . Negative_regulation EPHB2 NA 20460760 2257491 Furthermore , *attenuated* shikonin induced [ERK] phosphorylation . Negative_regulation EPHB2 NA 20554190 2327592 Oligonol and *inhibit* PMA induced [ERK] phosphorylation and ROS production . Negative_regulation EPHB2 NA 20868662 2363905 Carnosine alleviated all these alterations induced by MDA , but merely *inhibited* Bcl-2 family related activation of JNK and [ERK] . Negative_regulation EPHB2 NA 21453688 2448134 Activation of [ERK] and JNK , but not p38 , via phosphorylation induction was identified in EPO1- but not EPO- or EPO2 treated U87 and C6 cells , and this was *blocked* by adding . Negative_regulation EPHB2 NA 23337889 2827427 In addition , ( an antioxidant ) *inhibited* PDT induced fibroblast proliferation and [ERK] activation indicating that prolonged ERK activation and intracellular ROS contribute to the proliferation of fibroblasts and the dermal remodeling process for skin rejuvenation . Negative_regulation EPHB2 NAB1 16800929 1579382 The results showed that the expression level of phosphorylated [ERK] was *down-regulated* by the 1 mmol/L , and the level of total ERK had not changed . Negative_regulation EPHB2 NAB2 16800929 1579383 The results showed that the expression level of phosphorylated [ERK] was *down-regulated* by the 1 mmol/L , and the level of total ERK had not changed . Negative_regulation EPHB2 NANOG 22210859 2585952 overexpression or *inhibition* of [MAPK/ERK] signaling , both known to maintain mESCs in the absence of LIF , rescued Tet1 depletion , further supporting the dependence of LIF/Stat3 signaling on Tet1 . Negative_regulation EPHB2 NANP 19595442 2208829 *inhibited* collagen induced [ERK/p38] ( MAPK ) phosphorylation , which was enhanced by AACOCF ( 3 ) and reversed by a guanylate cyclase inhibitor ( ODQ ) . Negative_regulation EPHB2 NELFCD 20735431 2324062 Moreover , upregulation of in MDA-MB-231 cells *resulted* in the decrease of cyclin D1 , ß-catenin , and [ERK] activity , and the increase of p21 . Negative_regulation EPHB2 NELFCD 22238675 2538027 c-Src activates Ras-MAPK/ERK signaling pathway and regulates cell migration , while *inhibits* [MAPK/ERK] activation and cell migration through interaction with A-Raf and PAK1 and inhibiting their kinase activities . Negative_regulation EPHB2 NF1 25049390 2953476 Another patient harbored a missense mutation in that resulted in decreased protein stability and impaired ability to *suppress* [RAS-ERK] activation ; Negative_regulation EPHB2 NF2 18332868 1925109 Consistently , VprBP depletion abolished the in vivo interaction of and Roc1-Cullin4A-DDB1 , which resulted in Merlin stabilization and *inhibited* [ERK] and Rac activation . Negative_regulation EPHB2 NFATC1 20112358 2206301 IL-27 inhibited human osteoclastogenesis , suppressed the induction of , down-regulated the expression of RANK and triggering receptor expressed on myeloid cells 2 ( TREM-2 ) , and *inhibited* RANKL mediated activation of [ERK] , p38 , and NF-kappaB in osteoclast precursors . Negative_regulation EPHB2 NFE2L2 21270272 2380790 Forced activation of by adenoviral over-expression of Nrf2 *inhibited* the increased [ERK] activity and recovered the blunted insulin sensitivity on glucose uptake in cardiomyocytes that were chronically treated with H ( 2 ) O ( 2 ) . Negative_regulation EPHB2 NFKB1 15073167 1257640 By contrast , cisplatin , either alone or with [MEK/ERK] *inhibitors* , induced little activation in antisense PP4 transfected cells . Negative_regulation EPHB2 NFKB1 17189385 1662756 Inhibition of by overexpression of mutant IkappaB *increased* [ERK] phosphorylation . Negative_regulation EPHB2 NFKB1 17189385 1662774 Taken together , these results suggest that *inhibits* [ERK] activation to enhance cell survival during the development of tumor adaptive radioresistance . Negative_regulation EPHB2 NFKB1 19823174 2187268 Sulfur dioxide donor significantly downregulated Raf-1 , mitogen activated protein kinase kinase-1 ( MEK-1 ) and [p-ERK/ERK] , and *inhibited* pulmonary vascular smooth muscle cell proliferation , collagen remodeling and pulmonary vascular endothelial cell , and intercellular adhesion molecule 1 ( ICAM-1 ) expressions . Negative_regulation EPHB2 NFKB1 20403072 2282158 [MEK/ERK] inhibition also *induced* I-kappaB phosphorylation and enhanced binding activity , leading to expression of cellular inhibitors of apoptosis protein 2 ( c-IAP2 ) , a known nuclear factor-kappaB (NF-kappaB) regulated endogenous anti-apoptotic molecule . Negative_regulation EPHB2 NFKB1 9092580 422119 Inhibition of tyrosine kinase activity with genistein ( 10 microg/ml ) as well as selective MAP kinase inhibition with the MEK-1 inhibitor PD98059 abolished the VLA-4 dependent [ERK] tyrosine phosphorylation , *inhibited* nuclear binding , and abrogated tissue factor expression induced by both VLA-4 cross linking and adhesion to fibronectin in THP-1 cells and human peripheral blood monocytes . Negative_regulation EPHB2 NFKBIA 15073167 1257620 However , results of immunoblotting analysis showed that neither cisplatin nor [MEK/ERK] inhibitors *induced* marked degradation , suggesting that suppression of the MEK/ERK signaling pathway may enhance cisplatin induced NF-kappaB activation via mechanisms other than the conventional pathway . Negative_regulation EPHB2 NFKBIA 20133626 2213443 Degradation of , which is considered a primary requirement for NEMO mediated immune signaling , occurred normally in response to Toll-like receptor stimulation , yet [ERK] phosphorylation and NF-kappaB p65 nuclear translocation were severely *impaired* . Negative_regulation EPHB2 NGF 10349848 616977 *caused* similar levels of [ERK] activation in all subclones . Negative_regulation EPHB2 NGF 10585878 571579 However , PP2 inhibited [ERK] activation in response to NE and UTP , but not in *response* to EGF or . Negative_regulation EPHB2 NGF 8407983 233205 did not modulate the total amount of ERK proteins coimmunoprecipitated with p75 but did markedly *stimulate* the level of p75 associated [ERK] catalytic activity . Negative_regulation EPHB2 NOS2 18579559 1946572 Suppression of signaling by aminoguanidine *led* to decreased HCC growth and NF-kB and [RAS/ERK] expression and increased apoptosis both in vivo and in vitro . Negative_regulation EPHB2 NOS2 22197135 2544120 Viscolin blocked the expression of and COX-2 , and it also *inhibited* the [ERK] for the activation of NF-?B in LPS stimulated RAW 264.7 macrophages . Negative_regulation EPHB2 NOS3 20870034 2343038 In conclusion , KMUP-1 inhibits MCT induced PA proliferation by binding to 5-HT(2A) , 5-HT(2B) and 5-HT(2C) receptors , increasing endothelial receptor expression and NO release and *inhibiting* 5-HTT/RhoA/ROCK expression and [AKT/ERK] phosphorylation . Negative_regulation EPHB2 NOTCH1 19332065 2094096 In the IEC-6 cells , signaling activated the expression of EphrinB1 in an Hes1 independent manner , but *down-regulated* the expression of [EphB2] through the GSK3beta mediated inhibition of beta-catenin . Negative_regulation EPHB2 NOTCH1 24472723 2927677 Overexpression of *prevented* silibinin induced inhibition of [ERK] and Akt phosphorylation . Negative_regulation EPHB2 NOTCH2 19332065 2094097 In the IEC-6 cells , signaling activated the expression of EphrinB1 in an Hes1 independent manner , but *down-regulated* the expression of [EphB2] through the GSK3beta mediated inhibition of beta-catenin . Negative_regulation EPHB2 NOTCH3 19332065 2094098 In the IEC-6 cells , signaling activated the expression of EphrinB1 in an Hes1 independent manner , but *down-regulated* the expression of [EphB2] through the GSK3beta mediated inhibition of beta-catenin . Negative_regulation EPHB2 NOTCH3 23542683 2799754 Interestingly , carboplatin induced [ERK] phosphorylation is *inhibited* by activation . Negative_regulation EPHB2 NOTCH4 19332065 2094099 In the IEC-6 cells , signaling activated the expression of EphrinB1 in an Hes1 independent manner , but *down-regulated* the expression of [EphB2] through the GSK3beta mediated inhibition of beta-catenin . Negative_regulation EPHB2 NOX1 10965882 728022 In the presence of a inhibitor , diphenyleneiodonium ( DPI ) or an antioxidant , alpha-tocopherol , Ang II-induced protein tyrosine phosphorylation of two major proteins ( p120 , p70 ) and ERK activation were markedly *reduced* , whereas [ERK] activation by epidermal growth factor was unaffected . Negative_regulation EPHB2 NOX3 10965882 728023 In the *presence* of a inhibitor , diphenyleneiodonium ( DPI ) or an antioxidant , alpha-tocopherol , Ang II-induced protein tyrosine phosphorylation of two major proteins ( p120 , p70 ) and ERK activation were markedly reduced , whereas [ERK] activation by epidermal growth factor was unaffected . Negative_regulation EPHB2 NOX4 10965882 728024 In the presence of a inhibitor , diphenyleneiodonium ( DPI ) or an antioxidant , alpha-tocopherol , Ang II-induced protein tyrosine phosphorylation of two major proteins ( p120 , p70 ) and ERK activation were markedly *reduced* , whereas [ERK] activation by epidermal growth factor was unaffected . Negative_regulation EPHB2 NOX5 10965882 728021 In the *presence* of a inhibitor , diphenyleneiodonium ( DPI ) or an antioxidant , alpha-tocopherol , Ang II-induced protein tyrosine phosphorylation of two major proteins ( p120 , p70 ) and ERK activation were markedly reduced , whereas [ERK] activation by epidermal growth factor was unaffected . Negative_regulation EPHB2 NPPA 11171047 783715 Neither 8-bromo-cGMP nor ( 1-28 ) *inhibited* PDGF stimulated [ERK] activation , suggesting that the effects of cGMP and ANP ( 1-28 ) were not mediated by inhibition of this kinase . Negative_regulation EPHB2 NPPA 19837876 2165162 In contrast , *reduced* the levels of [phospho-ERK] in INS-1E cells . Negative_regulation EPHB2 NPPA 20519318 2295247 Ang II-stimulated [ERK] and Akt phosphorylation was *inhibited* by 100 nm . Negative_regulation EPHB2 NPPA 9573527 502451 We have reported that both extracellular signal regulated kinase ( ERK ) and c-Jun NH2-terminal kinase (JNK) are activated by ET-1 and ET-1 induced activation of [ERK] is *inhibited* by . Negative_regulation EPHB2 NPPB 9918806 559201 was also found to *inhibit* [ERK] and JNK/SAPK activation but not p38mapk with TNF-alpha stimulation . Negative_regulation EPHB2 NPPC 22700586 2633798 Two factors that promote chondrocyte differentiation , brain derived neurotrophic factor (BDNF) and , increase p38 activity while decreasing , but not completely *inhibiting* , [ERK] activity . Negative_regulation EPHB2 NPY4R 11136732 795020 The increase in [ERK] activity was *inhibited* by genistein and , but not by wortmannin , indicating that Src activation is necessary for the activation of the Ras/ERK pathway by CXCR3 . Negative_regulation EPHB2 NPY4R 11160627 781798 [ERK] activation induced by the PKC activator phorbol myristate acetate was *inhibited* by PTX , , AG1478 , and calphostin C . Negative_regulation EPHB2 NPY4R 11160627 781801 In contrast , activation of [ERK] by lysophosphatidic acid , a Gi-coupled receptor activator , was *inhibited* by PTX , , and AG1478 , but not by calphostin C . Negative_regulation EPHB2 NPY4R 11851354 913226 Furthermore , activation of [ERK] and Shc , and c- fos gene expression were significantly *inhibited* by AG1478 but not by cytochalasin D or . Negative_regulation EPHB2 NPY4R 12704650 1082366 [ERK] activation in response to microfilament disruption was *inhibited* completely by the broad-spectrum tyrosine kinase inhibitor genistein and the relatively src-kinase selective compound . Negative_regulation EPHB2 NPY4R 12911635 1122142 The phosphatase inhibitors okadaic acid and caliculyn A , but not cyclosporine A , *delayed* the removal of [ERK] and Akt phosphorylation under OGD . Negative_regulation EPHB2 NPY4R 21518335 2567455 The Phase II ( 5-10 min ) rapid decline in [ERK] phosphorylation *involves* PKA inhibition and serine/threonine phosphatase activation . Negative_regulation EPHB2 NPY4R 9724295 529411 However , in the *presence* of the selective phosphoprotein phosphatase ( ) inhibitor okadaic acid ( OA ) , a sustained increase in [ERK] activity , as well as in c-jun NH2-terminal protein kinase activity , in ARVM was observed . Negative_regulation EPHB2 NPY6R 10585878 571580 However , *inhibited* [ERK] activation in response to NE and UTP , but not in response to EGF or NGF . Negative_regulation EPHB2 NPY6R 10666504 665611 The major aim of the present study was to examine the mechanism of decrease in ERK activity by adrenomedullin and to identify the *role* of protein in the decrease in [ERK] activity , using okadaic acid [ 9,10-Deepithio-9,10-didehydroacanthifolicin ] , a selective inhibitor of PP2A at low nanomolar concentrations . Negative_regulation EPHB2 NPY6R 11454659 837705 also *prevented* the phosphorylation of [Erk] by UK14304 . Negative_regulation EPHB2 NPY6R 11562449 862833 Moreover , ( 20 nM ) , an inhibitor of Src , *blocked* D ( 4 ) receptor mediated SHC phosphorylation and [ERK] activation . Negative_regulation EPHB2 NPY6R 11713208 880655 , a Src family kinase inhibitor , *suppressed* not only E2-induced phosphorylation of c-Src , but [ERK] phosphorylation as well , suggesting that c-Src may be an upstream regulator of E2 signaling . Negative_regulation EPHB2 NPY6R 12435806 1015959 HU-210 induced [ERK] activation was *inhibited* by tyrphostin AG1478 and , widely employed inhibitors of the epidermal growth factor receptor ( EGF ( R ) ) and the Src family of cytosolic tyrosine kinases , respectively . Negative_regulation EPHB2 NPY6R 15886210 1433050 In addition , the Fyn inhibitor *blocked* 2-AG induced Fyn kinase activity and [ERK] phosphorylation and activity . Negative_regulation EPHB2 NPY6R 16341693 1553842 H2O2 induced [ERK] activation was *inhibited* by the Src family selective inhibitor and the epidermal growth factor receptor inhibitor AG1478 . Negative_regulation EPHB2 NPY6R 17895590 1802816 Ang II-enhanced cell migration was inhibited by SB203580 ( a p38 MAPK inhibitor ) and piceatannol ( a spleen tyrosine kinase inhibitor ) , but only partially by PD98059 ( an [ERK] *inhibitor* ) and ( a Src inhibitor ) . Negative_regulation EPHB2 NPY6R 19239475 2054862 The [ERK] activation , NF-kB translocation and PDGF-BB production were *blocked* by , U73122 and PD98059 . Negative_regulation EPHB2 NPY6R 19625610 2142920 Especially , phosphorylation of caveolin-1 is attenuated by AG1478 , herbimycin A ( tyrosine kinase inhibitors ) , and pyrazolopyrimidine 2 ( PP2 , Src inhibitor ) and EGF induced [ERK] activation was *blocked* by , methyl-beta-cyclodextrin ( MbetaCD ) , caveolin-1 small interfering RNA ( siRNA ) , LY-294002 [ phosphoinositol-3 kinase inhibitor ( PI3K ) ] , and Akt inhibitor . Negative_regulation EPHB2 NPY6R 19625610 2142928 EGF also significantly increases [ ( 3 ) H ] thymidine incorporation and cell number , which were significantly blocked by AG 1478 , , MbetaCD , caveolin-1 siRNA , FAK siRNA , LY-294002 , and PD-98059 ( [ERK] *inhibitor* ) . Negative_regulation EPHB2 NPY6R 21234229 2359622 Moreover , genistein and *blocked* the phosphorylation of [ERK] and p38 MAPK in neutrophils induced by E. histolytica . Negative_regulation EPHB2 NPY6R 23775084 2820298 We show that both chemical suppression and siRNA silencing of in T-cells *resulted* in sustained phosphorylation of MEK and [ERK] following stimulation with phorbol 12-myristate 13-acetate and ionomycin . Negative_regulation EPHB2 NPY6R 23775084 2820316 Similarly , in SLE T-cells , suppression of *resulted* in increased [MEK/ERK] phosphorylation , enhanced DNMT1 expression and suppressed expression of the methylation-sensitive CD70 gene . Negative_regulation EPHB2 NPY6R 23933651 2850121 Furthermore , both ZM241385 ( 100 nmol/L ) and the specific Src kinase inhibitor ( 5 µmol/L ) *blocked* D2R mediated [ERK] phosphorylation . Negative_regulation EPHB2 NPY6R 23942551 2855636 In STZ-diabetic mice , albuminuria , increased Src pTyr-416 , TACE activation , [ERK] and EGFR phosphorylation , glomerular collagen accumulation , and podocyte loss were *inhibited* by . Negative_regulation EPHB2 NPY6R 24091596 2874530 HMGB1 stimulation of HSC increased the phosphorylation of Src and [Erk] and HMGB1 induced HSC migration was *blocked* by the Src inhibitor and the Erk inhibitor U0126 . Negative_regulation EPHB2 NRAS 10666033 665343 Conditional overexpression *inhibited* urea- and NaCl-inducible [ERK] phosphorylation by 40-50 % , but only at 15 min , and not 5 min , of treatment . Negative_regulation EPHB2 NRAS 10727428 677894 Dominant negative *inhibited* both [ERK] activation and ANF up-regulation by Ang II , whereas constitutively active forms of Ras and MEK were sufficient to activate the ANF promoter . Negative_regulation EPHB2 NRAS 11018025 752776 Expression of a dominant negative mutant of also did not significantly *impair* calcium induced [ERK] activation , indicating that calcium mediated ERK activation does not require active Ras . Negative_regulation EPHB2 NRAS 11278310 810921 In contrast , inhibition of or Src *had* no effect on the sustained [ERK] activity , which was critically dependent on phosphatidylinositol 3-kinase . Negative_regulation EPHB2 NRAS 11418608 843261 VPA induced activation of [ERK] was *blocked* by the mitogen activated protein kinase/ERK kinase inhibitor PD098059 and dominant negative and Raf mutants but not by dominant negative stress activated protein kinase/ERK kinase and mitogen activated protein kinase kinase 6 mutants . Negative_regulation EPHB2 NRAS 11701752 878759 An expression of dominant inhibitory *inhibited* nicotine induced [ERK] phosphorylation . Negative_regulation EPHB2 NRAS 11709720 879944 Overexpression of galectin-1 increased membrane associated Ras , Ras-GTP , and active [ERK] resulting in cell transformation , which was *blocked* by dominant negative . Negative_regulation EPHB2 NRAS 11874466 918772 Further evidence for differential regulation of RAS and ERK is provided by the observations that TPO , which activates RAS but not protein kinase C , does not activate [ERK] , and that the inhibitor of SRC kinases PP1 *inhibits* activation of but not ERK2 in response to thrombin . Negative_regulation EPHB2 NRAS 11960991 953704 By contrast inhibition of , by inhibition of farnesyl transferase ( Ftase-1 ) or dominant negative ( N17 ) -Ras , significantly inhibited both E ( 2 ) - and TGF alpha induced [Erk] *activation* . Negative_regulation EPHB2 NRAS 12595244 1061192 Dominant negative , but not Rap , *blocks* NTF induced [ERK] activation and VR1 upregulation . Negative_regulation EPHB2 NRAS 14660603 1202126 However , when COS-1 cells were transfected with Ras complexed to CD8 , plasma membrane localization of was unaffected by AFC , yet EGF stimulated [Erk] activation was *inhibited* by AFC . Negative_regulation EPHB2 NRAS 14680820 1179144 Unexpectedly , dominant negative *blocked* activation of Ras and [ERK] in response to IL-2R engagement but not TCR/CD3 ligation . Negative_regulation EPHB2 NRAS 15070811 1265698 Specific IL-1 receptor antagonism and selective [MAPK/ERK] kinase or upstream *inhibition* prevented these increases , whereas PKC inhibition did not . Negative_regulation EPHB2 NRAS 15516985 1343128 was also constitutively active in patient NK cells , and exposure of cells to the Ras inhibitor FTI2153 or to dominant-negative-Ras *resulted* not only in [ERK] inhibition but also in enhanced apoptosis in both the presence and absence of anti-Fas . Negative_regulation EPHB2 NRAS 15855657 1439578 Expression of a dominant-inhibitory mutant of *reduced* complement mediated activation of [ERK] , but activation was not affected significantly by downregulation of protein kinase C. Complement induced ERK activation resulted in phosphorylation of cytosolic phospholipase A2 and was , in part , responsible for phosphorylation of mitogen activated protein kinase associated protein kinase-2 , but did not induce phosphorylation of the transcription factor , Elk-1 . Negative_regulation EPHB2 NRAS 17045653 1666539 In the present study , we investigated the *role* of in FLG- and LPS mediated signaling in [ERK] activation in chicken heterophils . Negative_regulation EPHB2 NRAS 18771726 1980328 We demonstrated here , that PTPIP51 could regulate ERK activity on Raf level , since MEK inhibitor and dominant negative Raf-1 but not could *inhibit* the [ERK] activation induced by PTPIP51 . Negative_regulation EPHB2 NRAS 22371971 2561699 Inhibition of calcineurin further reduced the phosphorylation of [ERK] and AKT ( at thr 308 ) and *inhibited* the activation of , but inhibitors of MAPK or PI3K signaling did not affect the circadian rhythm of calcineurin activity . Negative_regulation EPHB2 NRAS 22425622 2612641 DGKa knockdown impaired MEK and [ERK] phosphorylation , but did not *inhibit* activation in HCC cells . Negative_regulation EPHB2 NRAS 7862167 296216 Previous studies have indicated that activation of ERks in this cell line is dependent upon Ras since a dominant negative ( Asn-17 ) *blocks* [ERK] activation by insulin . Negative_regulation EPHB2 NRAS 8626428 355720 However , expression of dominant interfering ( N17Ras ) *inhibited* the insulin- but not osmotic shock stimulated phosphorylation of [ERK] and SOS . Negative_regulation EPHB2 NRAS 8758915 377895 [ERK] activation by BHTOOH was *inhibited* by suramin , and by expression of dominant negative in PC12 cells , suggesting overlap between the pathways for BHTOOH and growth factor signaling . Negative_regulation EPHB2 NRAS 8995450 409604 Expression of the mutant ( alpha ) i2 ( G203 ) , antisense G ( alpha ) i2 and a dominant negative ( N17Ras ) *prevented* shear dependent activation of [HA-ERK] , while that of ( alpha ) i2 ( G204 ) and antisense ( alpha ) i3 did not . Negative_regulation EPHB2 NRAS 9171350 433394 While the stimulation of [Erk] by alpha6beta4 was *suppressed* by dominant negative Shc , and RhoA , the activation of Jnk was inhibited by dominant negative Ras and Rac1 and by the phosphoinositide 3-kinase inhibitor Wortmannin . Negative_regulation EPHB2 NRAS 9564040 500702 Induction of ( N17 ) *blocked* EGF- but not Ang II- or phorbol ester ( TPA ) -dependent [ERK] activation . Negative_regulation EPHB2 NRAS 9593727 505784 Dominant negative mutants of ( but not Rac or Cdc42 ) specifically *inhibited* [ERK] activation by v-Fps and Myr-Fes , demonstrating that ERK activation occurs exclusively downstream of Ras . Negative_regulation EPHB2 NRAS 9763608 537163 Here we demonstrate that the BCR induced [ERK] activation is *reduced* by loss of Grb2 or expression of a dominant negative form of , RasN17 , whereas this response is not affected by loss of Shc . Negative_regulation EPHB2 NTRK1 11859925 893711 A double cysteine mutant exhibiting reduced NGF binding and *delayed* [Erk] signaling . Negative_regulation EPHB2 NUP43 11390379 849513 Co-expression of the CaR with a peptide derived from the region of the CaR C terminus that interacts with filamin reduced the ability of the CaR to activate in a dose dependent manner , but did not *inhibit* the ability of the ET ( A ) receptor to activate [ERK] . Negative_regulation EPHB2 OPN1LW 19366806 2065101 We show that the complex induces EphB4 and *represses* [EphB2] , in contrast to the beta-catenin-p300 complex . Negative_regulation EPHB2 OPN1LW 19620787 2118220 Overexpression of *enhanced* [ERK] phosphorylation and increased Ras activation in vitro . Negative_regulation EPHB2 P2RY2 17609252 1829032 In addition , activation of *prevents* growth factor induced phosphorylation of [Erk] ( 1,2 ) and Akt/PkB . Negative_regulation EPHB2 PAEP 22335188 2586613 [ERK] upregulation was *blocked* by BQ-123 and . Negative_regulation EPHB2 PAG1 21092590 2350054 An over-expression of in PC-3M-1E8 cells effectively *suppresses* the activation of Ras and [ERK] , as well as the cyclin D1 expression , leading to an inhibition of the proliferation ability of tumor cells . Negative_regulation EPHB2 PAK1 15601627 1356727 Furthermore , the synergistic activation of [Erk] was *inhibited* by expression of a dominant negative mutant of or that of Rac and was enhanced by an activated mutant of Pak1 . Negative_regulation EPHB2 PAK1 9234703 445386 Ras activation of [ERK] was *inhibited* by both Pak1 ( R299 ) and ( L83,L86,R299 ) , while neither mutant inhibited Raf activation of ERK . Negative_regulation EPHB2 PAK2 11278362 810953 In response to tumor necrosis factor alpha , expression of increases the early but *reduces* the late activation of [ERK] , JNK , and p38 . Negative_regulation EPHB2 PAQR3 17724343 1789883 expression *inhibits* EGF stimulated [ERK] and RSK phosphorylation , blocks NGF mediated PC12 cell differentiation , and antagonizes Ras- and Raf-1 stimulated Elk-1 transactivation . Negative_regulation EPHB2 PAQR3 18515281 1934194 When overexpressed in A375 , a human malignant melanoma cell line with B-Raf ( V600E ) , *inhibits* [ERK] activation , cell proliferation and transformation of A375 cells . Negative_regulation EPHB2 PAQR3 22828136 2687264 The cell proliferation rate , anchorage independent growth , EGF stimulated [ERK] phosphorylation and EGF induced nuclear accumulation of ß-catenin were *inhibited* by overexpression and enhanced by PAQR3 knockdown in SW-480 colorectal cancer cells . Negative_regulation EPHB2 PARP1 10476970 642770 This decrease in GTP bound *activates* [ERK/MAPK] . Negative_regulation EPHB2 PARP1 11228165 788455 Furthermore , overexpression of *enhanced* p38 activity but not [ERK] or JNK activity . Negative_regulation EPHB2 PARP1 11340161 812417 In NIH 3T3 cells , is *required* not only for cAMP 's inhibition of [ERK] activation but for inhibition of cell proliferation and mitogenesis as well . Negative_regulation EPHB2 PARP1 11479306 860613 Moreover , inhibition of by a Rap1 GTPase activating protein-1 also *resulted* in a decrease in [ERK] and Akt phosphorylation , which was not further decreased by cAMP , suggesting that cAMP inhibits ERK and Akt by inhibiting Rap1 . Negative_regulation EPHB2 PARP1 11479306 860669 The *role* of in [ERK] and Akt activity was further demonstrated by our observation that an active form of Epac , which activated Rap1 in the absence of cAMP , increased ERK and Akt phosphorylation . Negative_regulation EPHB2 PARP1 16507992 1529662 We confirm that the PKA independent activation of by Epac1 activates a perinuclear pool of Rap1 and that this does not *result* in [ERK] activation . Negative_regulation EPHB2 PARP1 20347949 2281907 In addition , MWG extract attenuated activation of caspase-3 and and *inhibited* the phosphorylation of [ERK] , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation EPHB2 PARP1 24084189 2882566 In the addition of PLX4032 to apigenin , compared with the treatment of apigenin alone , the protein levels of cleaved and cleaved caspase-3 were elevated , and [phospho-ERK] protein levels were *reduced* , and the protein levels of total ERK , c-Myc , BRAF , phospho-Akt , phospho-p70S6K and phospho-4EBP1 were not varied . Negative_regulation EPHB2 PARP10 20347949 2281902 In addition , MWG extract attenuated activation of caspase-3 and and *inhibited* the phosphorylation of [ERK] , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation EPHB2 PARP11 20347949 2281898 In addition , MWG extract attenuated activation of caspase-3 and and *inhibited* the phosphorylation of [ERK] , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation EPHB2 PARP12 20347949 2281900 In addition , MWG extract attenuated activation of caspase-3 and and *inhibited* the phosphorylation of [ERK] , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation EPHB2 PARP14 20347949 2281911 In addition , MWG extract attenuated activation of caspase-3 and and *inhibited* the phosphorylation of [ERK] , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation EPHB2 PARP15 20347949 2281905 In addition , MWG extract attenuated activation of caspase-3 and and *inhibited* the phosphorylation of [ERK] , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation EPHB2 PARP16 20347949 2281903 In addition , MWG extract attenuated activation of caspase-3 and and *inhibited* the phosphorylation of [ERK] , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation EPHB2 PARP2 20347949 2281909 In addition , MWG extract attenuated activation of caspase-3 and and *inhibited* the phosphorylation of [ERK] , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation EPHB2 PARP3 20347949 2281910 In addition , MWG extract attenuated activation of caspase-3 and and *inhibited* the phosphorylation of [ERK] , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation EPHB2 PARP4 20347949 2281908 In addition , MWG extract attenuated activation of caspase-3 and and *inhibited* the phosphorylation of [ERK] , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation EPHB2 PARP6 20347949 2281906 In addition , MWG extract attenuated activation of caspase-3 and and *inhibited* the phosphorylation of [ERK] , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation EPHB2 PARP8 20347949 2281904 In addition , MWG extract attenuated activation of caspase-3 and and *inhibited* the phosphorylation of [ERK] , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation EPHB2 PARP9 20347949 2281901 In addition , MWG extract attenuated activation of caspase-3 and and *inhibited* the phosphorylation of [ERK] , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation EPHB2 PCNA 14580716 1156991 We further show that normal rhesus OSE cells do not activate ERK or Akt in response to estradiol , nor does estradiol block the ability of serum to stimulate [ERK] or *induce* D expression . Negative_regulation EPHB2 PCSK1 21853090 2468861 We found that PKA-C§ expression , but not Jnk or [Erk] activation , was moderately *inhibited* by . Negative_regulation EPHB2 PDE10A 21816164 2490398 The inhibitor , papaverine , differentially *activates* [ERK] in male and female rat striatal slices . Negative_regulation EPHB2 PDGFA 21824285 2485337 Epinephrine enhanced S. sanguinis induced platelet aggregation and phosphorylation of phospholipase C?2 and [Erk] , but *inhibited* RANTES , PF4 , sCD40L and release . Negative_regulation EPHB2 PDGFB 11269657 797349 Unexpectedly , in V12Ras expressing-SMCs , arsenite stimulates ERK , but still decreases [ERK] activity in the *presence* of . Negative_regulation EPHB2 PDGFB 21824285 2485338 Epinephrine enhanced S. sanguinis induced platelet aggregation and phosphorylation of phospholipase C?2 and [Erk] , but *inhibited* RANTES , PF4 , sCD40L and release . Negative_regulation EPHB2 PEA15 10982386 731850 expression in Chinese hamster ovary cells *resulted* in an increased mitogen activated protein kinase kinase and [ERK] activity . Negative_regulation EPHB2 PEA15 10982386 731866 The ability of to simultaneously *inhibit* apoptosis and potentiate [Ras-to-Erk] signaling may be of importance for oncogenic processes . Negative_regulation EPHB2 PEA15 20406097 2315362 Both ERK2 overexpression and genetic silencing of by antisense oligonucleotides *increased* [ERK] nuclear accumulation and reduced CAR expression and adenoviral entry . Negative_regulation EPHB2 PEA15 22105357 2629394 These data reveal that not only *suppresses* [ERK] signaling and tumorigenesis but also alternatively enhances tumorigenesis in the context of active Ras . Negative_regulation EPHB2 PEA15 22213050 2629471 Phosphoprotein enriched in astrocytes 15 ( PEA15 ) binds [ERK] and RSK2 and high levels can *impair* ERK- and RSK2 dependent transcription . Negative_regulation EPHB2 PEBP1 10490027 645415 Downregulation of endogenous by expression of antisense RNA or antibody microinjection *induces* the activation of MEK- , [ERK-] and AP-1 dependent transcription . Negative_regulation EPHB2 PEBP1 19323783 2052485 *inhibits* [ERK/MAPK] signalling and this inhibition impedes HSC proliferation . Negative_regulation EPHB2 PEBP1 22492043 2583495 Collectively , our data reveal an important *role* of in the regulation of [MAPK/ERK] signaling in the SCN and photic entrainment of the SCN clock . Negative_regulation EPHB2 PEBP4 16865237 1592678 Simultaneously , silencing of in CaoV-3 cells *enhances* TRAIL induced [ERK] and JNK activation . Negative_regulation EPHB2 PF4 21824285 2485339 Epinephrine enhanced S. sanguinis induced platelet aggregation and phosphorylation of phospholipase C?2 and [Erk] , but *inhibited* RANTES , , sCD40L and PDGF-AB release . Negative_regulation EPHB2 PGC 20955697 2407035 Overexpression of decreased both basal and PDGF induced p38 MAPK phosphorylation , but it *had* no effect on [ERK] phosphorylation . Negative_regulation EPHB2 PHB 22999878 2679139 Binding of rocaglamides to prevents interaction between PHB and CRaf and , thereby , *inhibits* CRaf activation and subsequently [CRaf-MEK-ERK] signaling . Negative_regulation EPHB2 PHKA2 10934044 720401 In addition , and FPhy2 to a greater extent also *inhibited* [Erk] activation in cell adhesion whereas FAK and PFhy1 stimulated it , suggesting a role for Erk activation in mediating differential regulation of cell cycle by Pyk2 and FAK . Negative_regulation EPHB2 PHKA2 11851354 913219 *Role* of EGF Receptor and in endothelin-1 induced [ERK] activation in rat cardiomyocytes . Negative_regulation EPHB2 PHKA2 9774361 539708 Role of calcium-sensitive tyrosine kinase in angiotensin II *induced* [Ras/ERK] signaling . Negative_regulation EPHB2 PI3 12502866 1033846 Examination of viral DNA entry suggests a *role* for in HHV-8 entry into the target cells and a role for PKC-zeta , MEK , and [ERK] at a post-viral entry stage of infection . Negative_regulation EPHB2 PI3 12594849 1061082 The association of to H4/ICOS was enhanced by H4/ICOS cross linking , and PI-3K inhibitors *inhibited* [ERK] and JNK activation and IL-4/IL-10 secretion , but not p38 MAP kinase or ZAP-70 activation . Negative_regulation EPHB2 PI3 14993222 1236862 Interestingly , suppression of signaling by a dominant negative Akt *enhanced* [ERK] activity in cells stimulated with 10 ng/ml but not with 100 ng/ml IGF-I . Negative_regulation EPHB2 PI3 15177934 1255137 The effects of NT on [EGFR/ERK/Akt] activation and DNA synthesis were *attenuated* by PLC-inhibitor ( U73122 ) , PKC-inhibitors ( bisindolylmaleimide , staurosporine , rottlerin ) , MEK inhibitor ( U0126 ) and kinase inhibitors ( wortmannin , LY 294002 ) . Negative_regulation EPHB2 PI3 15791648 1397426 The inhibition of signaling by LY294002 *increased* the [Erk] activation induced by the mutant B-raf proteins , as well as by wild-type B-raf . Negative_regulation EPHB2 PI3 16706195 1496612 In this paper we have explored the role of different kinase pathways of signal transduction in proliferation control of E1A + Ras transformants , using specific *inhibitors* of MAP-kinases [ERK] , JNK , p38 and . Negative_regulation EPHB2 PI3 24327733 2880393 Expression of a constitutively active form of Rac1 in these breast cancer models blocked *induced* down-regulation of [ERK] phosphorylation , apoptosis , and mitigated PI3K inhibitor sensitivity in vivo . Negative_regulation EPHB2 PIK3C3 11483663 844504 Inhibition of protein kinase C ( PKC ) and *had* little effect on Zn2+ induced [ERK] activation . Negative_regulation EPHB2 PIK3C3 15263001 1296095 Inhibition of Akt or also *allowed* cAMP dependent activation of B-Raf and [ERK] in normal calcium . Negative_regulation EPHB2 PIK3CA 10495776 647137 The pathway leading to peroxisome proliferator induced ERK activation is different than that induced by phorbol ester or EGF , since the inhibitors *had* no effect on [ERK] phosphorylation induced by these agents . Negative_regulation EPHB2 PIK3CA 11027277 738748 PI3-K and endocytosis may also regulate ERK signaling at a second site downstream of Ras , since both rapid [ERK] *activation* and the Ras dependent activation of the MAP kinase kinase kinase B-Raf are blocked by inhibition of either or endocytosis . Negative_regulation EPHB2 PIK3CA 15205467 1281156 Thus , unlike galectin-1 , which prolongs Ras activation of [ERK] and *inhibits* , K-Ras-GTP/galectin-3 interactions promote , in addition to PI3-K and Raf-1 activation , a third inhibitory signal that attenuates active ERK . Negative_regulation EPHB2 PIK3CA 15242975 1282046 when was inhibited , [ERK] phosphorylation could be *induced* by microinjected activated Akt , indicating important cross-talk between the PI3K and ERK1/2 pathways . Negative_regulation EPHB2 PIK3CA 15337530 1291366 We have characterized the *role* of Drosophila and AKT in [ERK] pathway activation involving insulin induced proliferation using Drosophila Schneider cells . Negative_regulation EPHB2 PIK3CA 15344880 1292077 To study the *role* of in insulin stimulation of [ERK] , we employed PI3K inhibitor LY294002 and mouse embryonic R- fibroblasts lacking IGF-1 receptors . Negative_regulation EPHB2 PIK3CA 15344880 1292089 In these R- cells , *inhibition* by LY294002 enhanced insulin stimulation of [ERK] phosphorylation whereas LY294002 inhibited insulin stimulation of Akt phosphorylation . Negative_regulation EPHB2 PIK3CA 15344880 1292107 Increased insulin *stimulation* of [ERK] by inhibition was mediated by the MEK/ERK pathway , but did not involve inhibitory Ser259 phosphorylation of raf that was reported to be mediated by Akt . Negative_regulation EPHB2 PIK3CA 15344880 1292111 In summary , inhibition in R- cells *enhanced* insulin stimulation of [ERK] phosphorylation by mechanisms involving enhancement of IRS-1 tyrosine phosphorylation , IRS-1-Grb2 complex formation and the ras/MEK/ERK pathway . Negative_regulation EPHB2 PIK3CA 15385613 1300124 [ERK] *activation* by capsaicin and NGF was also blocked by inhibitors . Negative_regulation EPHB2 PIK3CA 16339552 1491632 A *role* for in TCR stimulated [ERK] activation leading to paxillin phosphorylation and CTL degranulation . Negative_regulation EPHB2 PIK3CA 18256541 1890950 Inhibition of with either LY294002 and wortmannin was *sufficient* to cause upregulation of [ERK] activity as measured by immunoblotting . Negative_regulation EPHB2 PIK3CA 18958173 1982860 In TSC2 ( -/- ) ASM cells specific inhibitors ( e.g. LY294002 , wortmannin ) and Akt1 siRNA *had* little effect on S6 and [ERK] phosphorylation . Negative_regulation EPHB2 PIK3CA 19179620 2049177 Blocking *prevented* strain stimulated [ERK] and p38 phosphorylation . Negative_regulation EPHB2 PIK3CA 19424594 2076407 Importantly , both inhibitor LY294002 and dominant negative Akt construct *promoted* tunicamycin- and thapsigargin induced [ERK] phosphorylation . Negative_regulation EPHB2 PIK3CA 20441566 2274831 In the present study , we evaluated the *role* of specific isoforms alpha , beta , gamma and delta in platelet aggregation , thromboxane A2 generation and [ERK] ( extracellular-signal regulated kinase ) activation . Negative_regulation EPHB2 PIK3CA 20441566 2274837 Our results show that loss of the signal *impaired* the ability of ADP to induce platelet aggregation , [ERK] phosphorylation and thromboxane A2 generation . Negative_regulation EPHB2 PIK3CA 21209852 2359322 Furthermore , LPA increased activity , and the PI3K inhibitor LY294002 *inhibited* both LPA induced [PAK1/ERK] activation and cell migration . Negative_regulation EPHB2 PIK3CA 21490369 2448485 GH-induced [ERK] *activation* was completely blocked by the ERK pathway inhibitor , U0126 , and the JAK2 inhibitor , 1,2,3,4,5,6-hexabromocyclohexane ( Hex ) , and was partially blocked by the inhibitor LY294002 . Negative_regulation EPHB2 PIK3CA 21904878 2501405 Lowering the phospho-Akt level by HNMPA or LY294002 , a inhibitor , further *augmented* exe-4 induced cAMP formation and [Erk] phosphorylation . Negative_regulation EPHB2 PIK3CA 24340098 2880806 Inhibiting ERK maintained the leptin induced up-regulation of p-Akt and p-p38MAPK while inhibiting *reduced* the level of [p-ERK] and p-Akt but maintained the increase in p-p38MAPK . Negative_regulation EPHB2 PIK3R1 10495776 647138 The pathway leading to peroxisome proliferator induced ERK activation is different than that induced by phorbol ester or EGF , since the inhibitors *had* no effect on [ERK] phosphorylation induced by these agents . Negative_regulation EPHB2 PIK3R1 11027277 738749 PI3-K and endocytosis may also regulate ERK signaling at a second site downstream of Ras , since both rapid [ERK] *activation* and the Ras dependent activation of the MAP kinase kinase kinase B-Raf are blocked by inhibition of either or endocytosis . Negative_regulation EPHB2 PIK3R1 15205467 1281157 Thus , unlike galectin-1 , which prolongs Ras activation of [ERK] and *inhibits* , K-Ras-GTP/galectin-3 interactions promote , in addition to PI3-K and Raf-1 activation , a third inhibitory signal that attenuates active ERK . Negative_regulation EPHB2 PIK3R1 15242975 1282047 when was inhibited , [ERK] phosphorylation could be *induced* by microinjected activated Akt , indicating important cross-talk between the PI3K and ERK1/2 pathways . Negative_regulation EPHB2 PIK3R1 15337530 1291367 We have characterized the *role* of Drosophila and AKT in [ERK] pathway activation involving insulin induced proliferation using Drosophila Schneider cells . Negative_regulation EPHB2 PIK3R1 15344880 1292078 To study the *role* of in insulin stimulation of [ERK] , we employed PI3K inhibitor LY294002 and mouse embryonic R- fibroblasts lacking IGF-1 receptors . Negative_regulation EPHB2 PIK3R1 15344880 1292090 In these R- cells , *inhibition* by LY294002 enhanced insulin stimulation of [ERK] phosphorylation whereas LY294002 inhibited insulin stimulation of Akt phosphorylation . Negative_regulation EPHB2 PIK3R1 15344880 1292108 Increased insulin *stimulation* of [ERK] by inhibition was mediated by the MEK/ERK pathway , but did not involve inhibitory Ser259 phosphorylation of raf that was reported to be mediated by Akt . Negative_regulation EPHB2 PIK3R1 15344880 1292112 In summary , inhibition in R- cells *enhanced* insulin stimulation of [ERK] phosphorylation by mechanisms involving enhancement of IRS-1 tyrosine phosphorylation , IRS-1-Grb2 complex formation and the ras/MEK/ERK pathway . Negative_regulation EPHB2 PIK3R1 15385613 1300125 [ERK] *activation* by capsaicin and NGF was also blocked by inhibitors . Negative_regulation EPHB2 PIK3R1 16339552 1491633 A *role* for in TCR stimulated [ERK] activation leading to paxillin phosphorylation and CTL degranulation . Negative_regulation EPHB2 PIK3R1 18256541 1890951 Inhibition of with either LY294002 and wortmannin was *sufficient* to cause upregulation of [ERK] activity as measured by immunoblotting . Negative_regulation EPHB2 PIK3R1 18958173 1982861 In TSC2 ( -/- ) ASM cells specific inhibitors ( e.g. LY294002 , wortmannin ) and Akt1 siRNA *had* little effect on S6 and [ERK] phosphorylation . Negative_regulation EPHB2 PIK3R1 19179620 2049178 Blocking *prevented* strain stimulated [ERK] and p38 phosphorylation . Negative_regulation EPHB2 PIK3R1 19424594 2076408 Importantly , both inhibitor LY294002 and dominant negative Akt construct *promoted* tunicamycin- and thapsigargin induced [ERK] phosphorylation . Negative_regulation EPHB2 PIK3R1 20441566 2274832 In the present study , we evaluated the *role* of specific isoforms alpha , beta , gamma and delta in platelet aggregation , thromboxane A2 generation and [ERK] ( extracellular-signal regulated kinase ) activation . Negative_regulation EPHB2 PIK3R1 20441566 2274838 Our results show that loss of the signal *impaired* the ability of ADP to induce platelet aggregation , [ERK] phosphorylation and thromboxane A2 generation . Negative_regulation EPHB2 PIK3R1 21209852 2359323 Furthermore , LPA increased activity , and the PI3K inhibitor LY294002 *inhibited* both LPA induced [PAK1/ERK] activation and cell migration . Negative_regulation EPHB2 PIK3R1 21490369 2448486 GH-induced [ERK] *activation* was completely blocked by the ERK pathway inhibitor , U0126 , and the JAK2 inhibitor , 1,2,3,4,5,6-hexabromocyclohexane ( Hex ) , and was partially blocked by the inhibitor LY294002 . Negative_regulation EPHB2 PIK3R1 21904878 2501406 Lowering the phospho-Akt level by HNMPA or LY294002 , a inhibitor , further *augmented* exe-4 induced cAMP formation and [Erk] phosphorylation . Negative_regulation EPHB2 PIK3R1 24340098 2880807 Inhibiting ERK maintained the leptin induced up-regulation of p-Akt and p-p38MAPK while inhibiting *reduced* the level of [p-ERK] and p-Akt but maintained the increase in p-p38MAPK . Negative_regulation EPHB2 PIK3R4 11483663 844505 Inhibition of protein kinase C ( PKC ) and *had* little effect on Zn2+ induced [ERK] activation . Negative_regulation EPHB2 PIK3R4 15263001 1296096 Inhibition of Akt or also *allowed* cAMP dependent activation of B-Raf and [ERK] in normal calcium . Negative_regulation EPHB2 PKN1 21037231 2370221 Overexpression of significantly *increased* [ERK] phosphorylation , whereas downregulation of PKN1 inhibited HS-induced ERK phosphorylation . Negative_regulation EPHB2 PKN1 21209852 2359314 In addition , LPA induced PAK1 activation while [ERK] activation and cell migration were *inhibited* by ectopic expression of an inactive mutant form of in MDA-MB-231 cells . Negative_regulation EPHB2 PKN1 23653349 2805318 We observed how that overexpression of a kinase-dead mutant form of *increased* phosphorylation of MEK1/2 ( Ser-217/Ser-221 ) and [ERK] ( Thr-202/Tyr-204 ) , although phosphorylation of B-RAF ( Ser-445 ) and C-RAF ( Ser-338 ) remained unchanged . Negative_regulation EPHB2 PKN1 9234703 445387 Ras activation of [ERK] was *inhibited* by both ( R299 ) and Pak1 ( L83,L86,R299 ) , while neither mutant inhibited Raf activation of ERK . Negative_regulation EPHB2 PLAU 16826166 1638590 Functional blockade of or inhibition of p70S6 kinase , but not *inhibition* of [Ras/ERK] signaling , suppresses this GM3 induced stimulation of cell proliferation . Negative_regulation EPHB2 PLCG1 17524370 1762098 HSV mediated overexpression of in PC12 cells *induced* [ERK] activation via a mechanism dependent , in part , on both MAP-ERK kinase (MEK) and protein kinase C . PLCgamma1 overexpression in the VTA similarly induced ERK activation in the VTA in vivo . Negative_regulation EPHB2 PLD1 12149127 997550 The *roles* of and PLD2 in [ERK] activation and IL-8 secretion activated by S1P were investigated by infecting cells with adenoviral constructs of wild-type and catalytically inactive mutants of PLD1 and PLD2 . Negative_regulation EPHB2 PLD1 22105357 2629384 Inhibition of or interference with PEA-15/PLD1 binding *blocked* PEA-15 's ability to increase [ERK] activation . Negative_regulation EPHB2 PLD1 24164897 2889683 While inhibition of both and DGK *had* no effect on the overall [ERK] activity , inhibition of PLD2 but not PLD1 or DGK blocked the nuclear ERK activity in several cancer cell lines . Negative_regulation EPHB2 PLD2 12149127 997551 The *roles* of PLD1 and in [ERK] activation and IL-8 secretion activated by S1P were investigated by infecting cells with adenoviral constructs of wild-type and catalytically inactive mutants of PLD1 and PLD2 . Negative_regulation EPHB2 PLD2 24164897 2889684 While inhibition of both and DGK *had* no effect on the overall [ERK] activity , inhibition of PLD2 but not PLD1 or DGK blocked the nuclear ERK activity in several cancer cell lines . Negative_regulation EPHB2 PLD3 24164897 2889679 While inhibition of both and DGK *had* no effect on the overall [ERK] activity , inhibition of PLD2 but not PLD1 or DGK blocked the nuclear ERK activity in several cancer cell lines . Negative_regulation EPHB2 PLD4 24164897 2889680 While inhibition of both and DGK *had* no effect on the overall [ERK] activity , inhibition of PLD2 but not PLD1 or DGK blocked the nuclear ERK activity in several cancer cell lines . Negative_regulation EPHB2 PLD5 24164897 2889681 While inhibition of both and DGK *had* no effect on the overall [ERK] activity , inhibition of PLD2 but not PLD1 or DGK blocked the nuclear ERK activity in several cancer cell lines . Negative_regulation EPHB2 PLD6 24164897 2889682 While inhibition of both and DGK *had* no effect on the overall [ERK] activity , inhibition of PLD2 but not PLD1 or DGK blocked the nuclear ERK activity in several cancer cell lines . Negative_regulation EPHB2 POLDIP2 17615677 1769052 We conclude that [ERK] activation and MAPK *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation EPHB2 POLDIP2 18443411 1926737 These results suggest that cyclic stretch inhibits the myogenic differentiation of C2C12 cells by activating mediated signaling and *inhibiting* [ERK] phosphorylation . Negative_regulation EPHB2 POLDIP2 22129085 2624036 Treatment with 1 , 10 and 100 µg/ml AAE concentration-dependently inhibited the release of cytokines ( tumor necrosis factor-a , interleukin (IL) -6 , and IL-8 ) and phosphorylation of [ERK] and JNK induced by PMACI in HMC-1 cells , but it did not *inhibit* the phosphorylation of . Negative_regulation EPHB2 PON1 23772025 2807573 *inhibited* the TCR induced activation of [ERK-MAPK] signaling and the nuclear translocation of NF-?B in CD4 T cells . Negative_regulation EPHB2 PPARGC1A 17987121 1821452 Mechanistic study demonstrated that the effects of on VSMC proliferation and migration result from its capacity to *prevent* [ERK] phosphorylation . Negative_regulation EPHB2 PPME1 19293187 2056020 Here , we show that methylesterase mediated inhibition of the protein phosphatase 2A *promotes* basal [ERK] pathway activity and is required for efficient growth factor response . Negative_regulation EPHB2 PPP2CA 12911635 1122139 The phosphatase inhibitors okadaic acid and caliculyn A , but not cyclosporine A , *delayed* the removal of [ERK] and Akt phosphorylation under OGD . Negative_regulation EPHB2 PPP2CA 12937125 1132907 In this study , we show that chronic inhibition of activity in L199P transgenic mice *causes* the activation of [ERK] and JNK as demonstrated by the phosphorylation and nuclear accumulation of the ERK and JNK substrates , Elk-1 and c-Jun. TUNEL staining revealed that activated JNK signaling was not associated with cell death . Negative_regulation EPHB2 PPP2CA 18332424 1886410 blocking of by okadaic acid could successfully *restore* normal [ERK] activation in KO synaptoneurosomes . Negative_regulation EPHB2 PPP2CA 19286927 2063868 We also found that inhibition *resulted* in prolonged activation of JNK , p38 , and [ERK] resulting in both increased transcriptional activation of the IL-8 promoter and posttranscriptional stabilization of IL-8 mRNA . Negative_regulation EPHB2 PPP2CA 19602257 2112085 In addition , the inhibitor , cantharidin , *led* to an up-regulation of [ERK] activity and was able to counteract Src inhibition during ischemia . Negative_regulation EPHB2 PPP2CA 21030067 2354438 Inhibition of in benign cells *resulted* in an increase in [ERK] activation and in TGF-ß1 auto-induction after TGF-ß1 ( 10 ng/mL ) treatment . Negative_regulation EPHB2 PPP2CA 21518335 2567452 The Phase II ( 5-10 min ) rapid decline in [ERK] phosphorylation *involves* PKA inhibition and serine/threonine phosphatase activation . Negative_regulation EPHB2 PPP2CA 22345558 2572007 The activated then *suppressed* [ERK] signaling through dephosphorylation of ERK and induced apoptosis . Negative_regulation EPHB2 PPP2CA 23017243 2694410 Novel involvement of leukotriene B4 receptor 2 through [ERK] *activation* by down-regulation in leukotriene B4-induced keratin phosphorylation and reorganization of pancreatic cancer cells . Negative_regulation EPHB2 PPP2CA 9724295 529408 However , in the *presence* of the selective phosphoprotein phosphatase ( ) inhibitor okadaic acid ( OA ) , a sustained increase in [ERK] activity , as well as in c-jun NH2-terminal protein kinase activity , in ARVM was observed . Negative_regulation EPHB2 PPP2R1A 12911635 1122140 The phosphatase inhibitors okadaic acid and caliculyn A , but not cyclosporine A , *delayed* the removal of [ERK] and Akt phosphorylation under OGD . Negative_regulation EPHB2 PPP2R1A 12937125 1132908 In this study , we show that chronic inhibition of activity in L199P transgenic mice *causes* the activation of [ERK] and JNK as demonstrated by the phosphorylation and nuclear accumulation of the ERK and JNK substrates , Elk-1 and c-Jun. TUNEL staining revealed that activated JNK signaling was not associated with cell death . Negative_regulation EPHB2 PPP2R1A 18332424 1886411 blocking of by okadaic acid could successfully *restore* normal [ERK] activation in KO synaptoneurosomes . Negative_regulation EPHB2 PPP2R1A 19286927 2063869 We also found that inhibition *resulted* in prolonged activation of JNK , p38 , and [ERK] resulting in both increased transcriptional activation of the IL-8 promoter and posttranscriptional stabilization of IL-8 mRNA . Negative_regulation EPHB2 PPP2R1A 19602257 2112086 In addition , the inhibitor , cantharidin , *led* to an up-regulation of [ERK] activity and was able to counteract Src inhibition during ischemia . Negative_regulation EPHB2 PPP2R1A 21030067 2354439 Inhibition of in benign cells *resulted* in an increase in [ERK] activation and in TGF-ß1 auto-induction after TGF-ß1 ( 10 ng/mL ) treatment . Negative_regulation EPHB2 PPP2R1A 21518335 2567453 The Phase II ( 5-10 min ) rapid decline in [ERK] phosphorylation *involves* PKA inhibition and serine/threonine phosphatase activation . Negative_regulation EPHB2 PPP2R1A 22345558 2572008 The activated then *suppressed* [ERK] signaling through dephosphorylation of ERK and induced apoptosis . Negative_regulation EPHB2 PPP2R1A 23017243 2694411 Novel involvement of leukotriene B4 receptor 2 through [ERK] *activation* by down-regulation in leukotriene B4-induced keratin phosphorylation and reorganization of pancreatic cancer cells . Negative_regulation EPHB2 PPP2R1A 9724295 529409 However , in the *presence* of the selective phosphoprotein phosphatase ( ) inhibitor okadaic acid ( OA ) , a sustained increase in [ERK] activity , as well as in c-jun NH2-terminal protein kinase activity , in ARVM was observed . Negative_regulation EPHB2 PPP2R2B 12911635 1122141 The phosphatase inhibitors okadaic acid and caliculyn A , but not cyclosporine A , *delayed* the removal of [ERK] and Akt phosphorylation under OGD . Negative_regulation EPHB2 PPP2R2B 12937125 1132909 In this study , we show that chronic inhibition of activity in L199P transgenic mice *causes* the activation of [ERK] and JNK as demonstrated by the phosphorylation and nuclear accumulation of the ERK and JNK substrates , Elk-1 and c-Jun. TUNEL staining revealed that activated JNK signaling was not associated with cell death . Negative_regulation EPHB2 PPP2R2B 18332424 1886412 blocking of by okadaic acid could successfully *restore* normal [ERK] activation in KO synaptoneurosomes . Negative_regulation EPHB2 PPP2R2B 19286927 2063870 We also found that inhibition *resulted* in prolonged activation of JNK , p38 , and [ERK] resulting in both increased transcriptional activation of the IL-8 promoter and posttranscriptional stabilization of IL-8 mRNA . Negative_regulation EPHB2 PPP2R2B 19602257 2112087 In addition , the inhibitor , cantharidin , *led* to an up-regulation of [ERK] activity and was able to counteract Src inhibition during ischemia . Negative_regulation EPHB2 PPP2R2B 21030067 2354440 Inhibition of in benign cells *resulted* in an increase in [ERK] activation and in TGF-ß1 auto-induction after TGF-ß1 ( 10 ng/mL ) treatment . Negative_regulation EPHB2 PPP2R2B 21518335 2567454 The Phase II ( 5-10 min ) rapid decline in [ERK] phosphorylation *involves* PKA inhibition and serine/threonine phosphatase activation . Negative_regulation EPHB2 PPP2R2B 22345558 2572009 The activated then *suppressed* [ERK] signaling through dephosphorylation of ERK and induced apoptosis . Negative_regulation EPHB2 PPP2R2B 23017243 2694412 Novel involvement of leukotriene B4 receptor 2 through [ERK] *activation* by down-regulation in leukotriene B4-induced keratin phosphorylation and reorganization of pancreatic cancer cells . Negative_regulation EPHB2 PPP2R2B 9724295 529410 However , in the *presence* of the selective phosphoprotein phosphatase ( ) inhibitor okadaic acid ( OA ) , a sustained increase in [ERK] activity , as well as in c-jun NH2-terminal protein kinase activity , in ARVM was observed . Negative_regulation EPHB2 PPP3CA 15030770 1223168 Unexpectedly , we found that removal of activity from thymocytes *results* in inefficient [ERK] activation at the double positive stage of thymocyte development , when selection occurs . Negative_regulation EPHB2 PPP3CB 15030770 1223169 Unexpectedly , we found that removal of activity from thymocytes *results* in inefficient [ERK] activation at the double positive stage of thymocyte development , when selection occurs . Negative_regulation EPHB2 PPP3CC 15030770 1223170 Unexpectedly , we found that removal of activity from thymocytes *results* in inefficient [ERK] activation at the double positive stage of thymocyte development , when selection occurs . Negative_regulation EPHB2 PPP3R1 18184875 1875996 Furthermore , Western blot demonstrated that inhibition of with cyclosporin A or small interfering RNA *increased* the phosphorylation of [ERK] and p38 MAPK . Negative_regulation EPHB2 PRDX2 20553909 2290045 Our results show , for the first time , that *inhibits* TGF-beta1 induced [ERK] activation and overrides pro-apoptotic signals like Smad3 and p38 in human RPTECs . Negative_regulation EPHB2 PRKAA1 11262401 818790 Activation of by AICAR in NIH-3T3 cells *resulted* in drastic inhibitions of Ras , Raf-1 , and [Erk] activation induced by insulin-like growth factor 1 (IGF-1) . Negative_regulation EPHB2 PRKAA1 15558058 1343416 In cultures of cardiac myocytes , adiponectin activated and *inhibited* agonist stimulated hypertrophy and [ERK] activation . Negative_regulation EPHB2 PRKAA1 18098312 1862658 activation did not *reduce* PDGF dependent activation of extracellular signal regulated kinase ( [ERK] ) or Akt at early time points , whereas a marked inhibition was observed 24 hours after addition of PDGF , reflecting a block in cell cycle progression . Negative_regulation EPHB2 PRKAA1 20220132 2249366 Under these conditions , inhibition of endogenous by expressing a dominant negative form significantly *potentiated* [ERK] activation , indicating that glucose deprivation induced AMPK is specifically antagonizing ERK activity in HCT116 cells . Negative_regulation EPHB2 PRKAA1 21052866 2382658 Furthermore , we found that activated by adiponectin *reduced* [ERK] phosphorylation , which possibly impaired GnRH secretion in GT1-7 cells . Negative_regulation EPHB2 PRKAA1 21666115 2470858 Thus APN inhibits ROS induced cardiomyocyte remodeling by activating and *inhibiting* [ERK] signaling and NF-?B activity . Negative_regulation EPHB2 PRKAA1 22269797 2559852 We reasoned that activators of AMP activated protein kinase (AMPK) may represent a novel treatment avenue for the local treatment of incision induced pain because activators *inhibit* [ERK] and mTOR signaling , two important pathways involved in the sensitization of peripheral nociceptors . Negative_regulation EPHB2 PRKAA2 11262401 818791 Activation of by AICAR in NIH-3T3 cells resulted in drastic *inhibitions* of Ras , Raf-1 , and [Erk] activation induced by insulin-like growth factor 1 (IGF-1) . Negative_regulation EPHB2 PRKAA2 15558058 1343417 In cultures of cardiac myocytes , adiponectin activated and *inhibited* agonist stimulated hypertrophy and [ERK] activation . Negative_regulation EPHB2 PRKAA2 18098312 1862659 activation did not *reduce* PDGF dependent activation of extracellular signal regulated kinase ( [ERK] ) or Akt at early time points , whereas a marked inhibition was observed 24 hours after addition of PDGF , reflecting a block in cell cycle progression . Negative_regulation EPHB2 PRKAA2 20220132 2249367 Under these conditions , inhibition of endogenous by expressing a dominant negative form significantly *potentiated* [ERK] activation , indicating that glucose deprivation induced AMPK is specifically antagonizing ERK activity in HCT116 cells . Negative_regulation EPHB2 PRKAA2 21052866 2382659 Furthermore , we found that activated by adiponectin *reduced* [ERK] phosphorylation , which possibly impaired GnRH secretion in GT1-7 cells . Negative_regulation EPHB2 PRKAA2 21666115 2470859 Thus APN inhibits ROS induced cardiomyocyte remodeling by activating and *inhibiting* [ERK] signaling and NF-?B activity . Negative_regulation EPHB2 PRKAA2 22269797 2559853 We reasoned that activators of AMP activated protein kinase (AMPK) may represent a novel treatment avenue for the local treatment of incision induced pain because activators *inhibit* [ERK] and mTOR signaling , two important pathways involved in the sensitization of peripheral nociceptors . Negative_regulation EPHB2 PRKAB1 11262401 818792 Activation of by AICAR in NIH-3T3 cells *resulted* in drastic inhibitions of Ras , Raf-1 , and [Erk] activation induced by insulin-like growth factor 1 (IGF-1) . Negative_regulation EPHB2 PRKAB1 15558058 1343418 In cultures of cardiac myocytes , adiponectin activated and *inhibited* agonist stimulated hypertrophy and [ERK] activation . Negative_regulation EPHB2 PRKAB1 18098312 1862660 activation did not *reduce* PDGF dependent activation of extracellular signal regulated kinase ( [ERK] ) or Akt at early time points , whereas a marked inhibition was observed 24 hours after addition of PDGF , reflecting a block in cell cycle progression . Negative_regulation EPHB2 PRKAB1 20220132 2249368 Under these conditions , inhibition of endogenous by expressing a dominant negative form significantly *potentiated* [ERK] activation , indicating that glucose deprivation induced AMPK is specifically antagonizing ERK activity in HCT116 cells . Negative_regulation EPHB2 PRKAB1 21052866 2382660 Furthermore , we found that activated by adiponectin *reduced* [ERK] phosphorylation , which possibly impaired GnRH secretion in GT1-7 cells . Negative_regulation EPHB2 PRKAB1 21666115 2470860 Thus APN inhibits ROS induced cardiomyocyte remodeling by activating and *inhibiting* [ERK] signaling and NF-?B activity . Negative_regulation EPHB2 PRKAB1 22269797 2559854 We reasoned that activators of AMP activated protein kinase (AMPK) may represent a novel treatment avenue for the local treatment of incision induced pain because activators *inhibit* [ERK] and mTOR signaling , two important pathways involved in the sensitization of peripheral nociceptors . Negative_regulation EPHB2 PRKAB2 11262401 818793 Activation of by AICAR in NIH-3T3 cells resulted in drastic *inhibitions* of Ras , Raf-1 , and [Erk] activation induced by insulin-like growth factor 1 (IGF-1) . Negative_regulation EPHB2 PRKAB2 15558058 1343419 In cultures of cardiac myocytes , adiponectin activated and *inhibited* agonist stimulated hypertrophy and [ERK] activation . Negative_regulation EPHB2 PRKAB2 18098312 1862661 activation did not *reduce* PDGF dependent activation of extracellular signal regulated kinase ( [ERK] ) or Akt at early time points , whereas a marked inhibition was observed 24 hours after addition of PDGF , reflecting a block in cell cycle progression . Negative_regulation EPHB2 PRKAB2 20220132 2249369 Under these conditions , inhibition of endogenous by expressing a dominant negative form significantly *potentiated* [ERK] activation , indicating that glucose deprivation induced AMPK is specifically antagonizing ERK activity in HCT116 cells . Negative_regulation EPHB2 PRKAB2 21052866 2382661 Furthermore , we found that activated by adiponectin *reduced* [ERK] phosphorylation , which possibly impaired GnRH secretion in GT1-7 cells . Negative_regulation EPHB2 PRKAB2 21666115 2470861 Thus APN inhibits ROS induced cardiomyocyte remodeling by activating and *inhibiting* [ERK] signaling and NF-?B activity . Negative_regulation EPHB2 PRKAB2 22269797 2559855 We reasoned that activators of AMP activated protein kinase (AMPK) may represent a novel treatment avenue for the local treatment of incision induced pain because activators *inhibit* [ERK] and mTOR signaling , two important pathways involved in the sensitization of peripheral nociceptors . Negative_regulation EPHB2 PRKACB 10903877 713251 Activation of by 8-bromo-cyclic AMP or forskolin , and inhibition of PKC by calphostin C , *resulted* in a significant decrease in 3TP activity as well as in vitro [ERK] kinase activity in CRAC . Negative_regulation EPHB2 PRKACB 11971957 933699 Using RafS259 mutants we also demonstrate that Raf-1 is the sole target for *inhibition* of [ERK] and ERK induced gene expression , and that Raf-1 inhibition is mediated mainly through serine 259 phosphorylation . Negative_regulation EPHB2 PRKACB 15753041 1380053 Finally , direct inhibition of transiently *activates* [ERK] , demonstrating that ERK acts downstream of PKA . Negative_regulation EPHB2 PRKACB 15899852 1408867 Finally , strong phosphorylation of Raf-1 S338 provided resistance to mediated *inhibition* of [ERK] activation . Negative_regulation EPHB2 PRKACB 16123167 1482289 Inhibition of Galphai signaling or activity *blocked* the ability of ICI182,780 to rapidly stimulate [ERK] signaling . Negative_regulation EPHB2 PRKACB 19741198 2152986 In contrast , in the absence of GPR30 expression in cultured VSMC , estradiol stimulated activity and *inhibited* [ERK] phosphorylation . Negative_regulation EPHB2 PRKACB 20015475 2200034 Prostaglandin E2 activates cAMP response element binding protein in glioma cells via a signaling pathway involving dependent *inhibition* of [ERK] . Negative_regulation EPHB2 PRKACB 20804494 2363536 Activation of both Epac and similarly *prevented* PDGF induced phenotype switching and PDGF induced activation of [ERK] . Negative_regulation EPHB2 PRKACB 22634165 2620195 This negative effect was well correlated with increased cAMP levels via activity and the subsequent *inhibition* of [ERK] ( p42/p44 ) phosphorylation to decrease superoxide anion production . Negative_regulation EPHB2 PRKACB 24842369 2940254 In contradiction to previous in vitro studies that showed ERK activation by prostaglandin E2 ( PGE2 ) engagement with prostaglandin receptor EP4 , intravenous administration of EP4 agonist activated , *inhibited* [ERK] , and suppressed migration of neutrophils . Negative_regulation EPHB2 PRKACG 10903877 713252 Activation of by 8-bromo-cyclic AMP or forskolin , and inhibition of PKC by calphostin C , *resulted* in a significant decrease in 3TP activity as well as in vitro [ERK] kinase activity in CRAC . Negative_regulation EPHB2 PRKACG 11971957 933700 Using RafS259 mutants we also demonstrate that Raf-1 is the sole target for *inhibition* of [ERK] and ERK induced gene expression , and that Raf-1 inhibition is mediated mainly through serine 259 phosphorylation . Negative_regulation EPHB2 PRKACG 15753041 1380054 Finally , direct inhibition of transiently *activates* [ERK] , demonstrating that ERK acts downstream of PKA . Negative_regulation EPHB2 PRKACG 15899852 1408868 Finally , strong phosphorylation of Raf-1 S338 provided resistance to *mediated* inhibition of [ERK] activation . Negative_regulation EPHB2 PRKACG 16123167 1482290 Inhibition of Galphai signaling or activity *blocked* the ability of ICI182,780 to rapidly stimulate [ERK] signaling . Negative_regulation EPHB2 PRKACG 19741198 2152987 In contrast , in the absence of GPR30 expression in cultured VSMC , estradiol stimulated activity and *inhibited* [ERK] phosphorylation . Negative_regulation EPHB2 PRKACG 20015475 2200035 Prostaglandin E2 activates cAMP response element binding protein in glioma cells via a signaling pathway involving dependent *inhibition* of [ERK] . Negative_regulation EPHB2 PRKACG 20804494 2363537 Activation of both Epac and similarly *prevented* PDGF induced phenotype switching and PDGF induced activation of [ERK] . Negative_regulation EPHB2 PRKACG 22634165 2620196 This negative effect was well correlated with increased cAMP levels via activity and the subsequent *inhibition* of [ERK] ( p42/p44 ) phosphorylation to decrease superoxide anion production . Negative_regulation EPHB2 PRKACG 24842369 2940255 In contradiction to previous in vitro studies that showed ERK activation by prostaglandin E2 ( PGE2 ) engagement with prostaglandin receptor EP4 , intravenous administration of EP4 agonist activated , *inhibited* [ERK] , and suppressed migration of neutrophils . Negative_regulation EPHB2 PRKAG1 11262401 818794 Activation of by AICAR in NIH-3T3 cells resulted in drastic *inhibitions* of Ras , Raf-1 , and [Erk] activation induced by insulin-like growth factor 1 (IGF-1) . Negative_regulation EPHB2 PRKAG1 15558058 1343420 In cultures of cardiac myocytes , adiponectin activated and *inhibited* agonist stimulated hypertrophy and [ERK] activation . Negative_regulation EPHB2 PRKAG1 18098312 1862662 activation did not *reduce* PDGF dependent activation of extracellular signal regulated kinase ( [ERK] ) or Akt at early time points , whereas a marked inhibition was observed 24 hours after addition of PDGF , reflecting a block in cell cycle progression . Negative_regulation EPHB2 PRKAG1 20220132 2249370 Under these conditions , inhibition of endogenous by expressing a dominant negative form significantly *potentiated* [ERK] activation , indicating that glucose deprivation induced AMPK is specifically antagonizing ERK activity in HCT116 cells . Negative_regulation EPHB2 PRKAG1 21052866 2382662 Furthermore , we found that activated by adiponectin *reduced* [ERK] phosphorylation , which possibly impaired GnRH secretion in GT1-7 cells . Negative_regulation EPHB2 PRKAG1 21666115 2470862 Thus APN inhibits ROS induced cardiomyocyte remodeling by activating and *inhibiting* [ERK] signaling and NF-?B activity . Negative_regulation EPHB2 PRKAG1 22269797 2559856 We reasoned that activators of AMP activated protein kinase (AMPK) may represent a novel treatment avenue for the local treatment of incision induced pain because activators *inhibit* [ERK] and mTOR signaling , two important pathways involved in the sensitization of peripheral nociceptors . Negative_regulation EPHB2 PRKAG2 11262401 818795 Activation of by AICAR in NIH-3T3 cells *resulted* in drastic inhibitions of Ras , Raf-1 , and [Erk] activation induced by insulin-like growth factor 1 (IGF-1) . Negative_regulation EPHB2 PRKAG2 15558058 1343421 In cultures of cardiac myocytes , adiponectin activated and *inhibited* agonist stimulated hypertrophy and [ERK] activation . Negative_regulation EPHB2 PRKAG2 18098312 1862663 activation did not *reduce* PDGF dependent activation of extracellular signal regulated kinase ( [ERK] ) or Akt at early time points , whereas a marked inhibition was observed 24 hours after addition of PDGF , reflecting a block in cell cycle progression . Negative_regulation EPHB2 PRKAG2 20220132 2249371 Under these conditions , inhibition of endogenous by expressing a dominant negative form significantly *potentiated* [ERK] activation , indicating that glucose deprivation induced AMPK is specifically antagonizing ERK activity in HCT116 cells . Negative_regulation EPHB2 PRKAG2 21052866 2382663 Furthermore , we found that activated by adiponectin *reduced* [ERK] phosphorylation , which possibly impaired GnRH secretion in GT1-7 cells . Negative_regulation EPHB2 PRKAG2 21666115 2470863 Thus APN inhibits ROS induced cardiomyocyte remodeling by activating and *inhibiting* [ERK] signaling and NF-?B activity . Negative_regulation EPHB2 PRKAG2 22269797 2559857 We reasoned that activators of AMP activated protein kinase (AMPK) may represent a novel treatment avenue for the local treatment of incision induced pain because activators *inhibit* [ERK] and mTOR signaling , two important pathways involved in the sensitization of peripheral nociceptors . Negative_regulation EPHB2 PRKAR1A 10903877 713253 Activation of by 8-bromo-cyclic AMP or forskolin , and inhibition of PKC by calphostin C , *resulted* in a significant decrease in 3TP activity as well as in vitro [ERK] kinase activity in CRAC . Negative_regulation EPHB2 PRKAR1A 11971957 933701 Using RafS259 mutants we also demonstrate that Raf-1 is the sole target for *inhibition* of [ERK] and ERK induced gene expression , and that Raf-1 inhibition is mediated mainly through serine 259 phosphorylation . Negative_regulation EPHB2 PRKAR1A 15753041 1380055 Finally , direct inhibition of transiently *activates* [ERK] , demonstrating that ERK acts downstream of PKA . Negative_regulation EPHB2 PRKAR1A 15899852 1408869 Finally , strong phosphorylation of Raf-1 S338 provided resistance to mediated *inhibition* of [ERK] activation . Negative_regulation EPHB2 PRKAR1A 16123167 1482291 Inhibition of Galphai signaling or activity *blocked* the ability of ICI182,780 to rapidly stimulate [ERK] signaling . Negative_regulation EPHB2 PRKAR1A 19741198 2152988 In contrast , in the absence of GPR30 expression in cultured VSMC , estradiol stimulated activity and *inhibited* [ERK] phosphorylation . Negative_regulation EPHB2 PRKAR1A 20015475 2200036 Prostaglandin E2 activates cAMP response element binding protein in glioma cells via a signaling pathway involving *dependent* inhibition of [ERK] . Negative_regulation EPHB2 PRKAR1A 20804494 2363538 Activation of both Epac and similarly *prevented* PDGF induced phenotype switching and PDGF induced activation of [ERK] . Negative_regulation EPHB2 PRKAR1A 22634165 2620197 This negative effect was well correlated with increased cAMP levels via activity and the subsequent *inhibition* of [ERK] ( p42/p44 ) phosphorylation to decrease superoxide anion production . Negative_regulation EPHB2 PRKAR1A 24842369 2940256 In contradiction to previous in vitro studies that showed ERK activation by prostaglandin E2 ( PGE2 ) engagement with prostaglandin receptor EP4 , intravenous administration of EP4 agonist activated , *inhibited* [ERK] , and suppressed migration of neutrophils . Negative_regulation EPHB2 PRKAR1B 10903877 713254 Activation of by 8-bromo-cyclic AMP or forskolin , and inhibition of PKC by calphostin C , *resulted* in a significant decrease in 3TP activity as well as in vitro [ERK] kinase activity in CRAC . Negative_regulation EPHB2 PRKAR1B 11971957 933702 Using RafS259 mutants we also demonstrate that Raf-1 is the sole target for *inhibition* of [ERK] and ERK induced gene expression , and that Raf-1 inhibition is mediated mainly through serine 259 phosphorylation . Negative_regulation EPHB2 PRKAR1B 15753041 1380056 Finally , direct inhibition of transiently *activates* [ERK] , demonstrating that ERK acts downstream of PKA . Negative_regulation EPHB2 PRKAR1B 15899852 1408870 Finally , strong phosphorylation of Raf-1 S338 provided resistance to mediated *inhibition* of [ERK] activation . Negative_regulation EPHB2 PRKAR1B 16123167 1482292 Inhibition of Galphai signaling or activity *blocked* the ability of ICI182,780 to rapidly stimulate [ERK] signaling . Negative_regulation EPHB2 PRKAR1B 19741198 2152989 In contrast , in the absence of GPR30 expression in cultured VSMC , estradiol stimulated activity and *inhibited* [ERK] phosphorylation . Negative_regulation EPHB2 PRKAR1B 20015475 2200037 Prostaglandin E2 activates cAMP response element binding protein in glioma cells via a signaling pathway involving dependent *inhibition* of [ERK] . Negative_regulation EPHB2 PRKAR1B 20804494 2363539 Activation of both Epac and similarly *prevented* PDGF induced phenotype switching and PDGF induced activation of [ERK] . Negative_regulation EPHB2 PRKAR1B 22634165 2620198 This negative effect was well correlated with increased cAMP levels via activity and the subsequent *inhibition* of [ERK] ( p42/p44 ) phosphorylation to decrease superoxide anion production . Negative_regulation EPHB2 PRKAR1B 24842369 2940257 In contradiction to previous in vitro studies that showed ERK activation by prostaglandin E2 ( PGE2 ) engagement with prostaglandin receptor EP4 , intravenous administration of EP4 agonist activated , *inhibited* [ERK] , and suppressed migration of neutrophils . Negative_regulation EPHB2 PRKAR2A 10903877 713255 Activation of by 8-bromo-cyclic AMP or forskolin , and inhibition of PKC by calphostin C , *resulted* in a significant decrease in 3TP activity as well as in vitro [ERK] kinase activity in CRAC . Negative_regulation EPHB2 PRKAR2A 11971957 933703 Using RafS259 mutants we also demonstrate that Raf-1 is the sole target for *inhibition* of [ERK] and ERK induced gene expression , and that Raf-1 inhibition is mediated mainly through serine 259 phosphorylation . Negative_regulation EPHB2 PRKAR2A 15753041 1380057 Finally , direct inhibition of transiently *activates* [ERK] , demonstrating that ERK acts downstream of PKA . Negative_regulation EPHB2 PRKAR2A 15899852 1408871 Finally , strong phosphorylation of Raf-1 S338 provided resistance to *mediated* inhibition of [ERK] activation . Negative_regulation EPHB2 PRKAR2A 16123167 1482293 Inhibition of Galphai signaling or activity *blocked* the ability of ICI182,780 to rapidly stimulate [ERK] signaling . Negative_regulation EPHB2 PRKAR2A 19741198 2152990 In contrast , in the absence of GPR30 expression in cultured VSMC , estradiol stimulated activity and *inhibited* [ERK] phosphorylation . Negative_regulation EPHB2 PRKAR2A 20015475 2200038 Prostaglandin E2 activates cAMP response element binding protein in glioma cells via a signaling pathway involving *dependent* inhibition of [ERK] . Negative_regulation EPHB2 PRKAR2A 20804494 2363540 Activation of both Epac and similarly *prevented* PDGF induced phenotype switching and PDGF induced activation of [ERK] . Negative_regulation EPHB2 PRKAR2A 22634165 2620199 This negative effect was well correlated with increased cAMP levels via activity and the subsequent *inhibition* of [ERK] ( p42/p44 ) phosphorylation to decrease superoxide anion production . Negative_regulation EPHB2 PRKAR2A 24842369 2940258 In contradiction to previous in vitro studies that showed ERK activation by prostaglandin E2 ( PGE2 ) engagement with prostaglandin receptor EP4 , intravenous administration of EP4 agonist activated , *inhibited* [ERK] , and suppressed migration of neutrophils . Negative_regulation EPHB2 PRKAR2B 10903877 713256 Activation of by 8-bromo-cyclic AMP or forskolin , and inhibition of PKC by calphostin C , *resulted* in a significant decrease in 3TP activity as well as in vitro [ERK] kinase activity in CRAC . Negative_regulation EPHB2 PRKAR2B 11971957 933704 Using RafS259 mutants we also demonstrate that Raf-1 is the sole target for *inhibition* of [ERK] and ERK induced gene expression , and that Raf-1 inhibition is mediated mainly through serine 259 phosphorylation . Negative_regulation EPHB2 PRKAR2B 15753041 1380058 Finally , direct inhibition of transiently *activates* [ERK] , demonstrating that ERK acts downstream of PKA . Negative_regulation EPHB2 PRKAR2B 15899852 1408872 Finally , strong phosphorylation of Raf-1 S338 provided resistance to mediated *inhibition* of [ERK] activation . Negative_regulation EPHB2 PRKAR2B 16123167 1482294 Inhibition of Galphai signaling or activity *blocked* the ability of ICI182,780 to rapidly stimulate [ERK] signaling . Negative_regulation EPHB2 PRKAR2B 19741198 2152991 In contrast , in the absence of GPR30 expression in cultured VSMC , estradiol stimulated activity and *inhibited* [ERK] phosphorylation . Negative_regulation EPHB2 PRKAR2B 20015475 2200039 Prostaglandin E2 activates cAMP response element binding protein in glioma cells via a signaling pathway involving dependent *inhibition* of [ERK] . Negative_regulation EPHB2 PRKAR2B 20804494 2363541 Activation of both Epac and similarly *prevented* PDGF induced phenotype switching and PDGF induced activation of [ERK] . Negative_regulation EPHB2 PRKAR2B 22634165 2620200 This negative effect was well correlated with increased cAMP levels via activity and the subsequent *inhibition* of [ERK] ( p42/p44 ) phosphorylation to decrease superoxide anion production . Negative_regulation EPHB2 PRKAR2B 24842369 2940259 In contradiction to previous in vitro studies that showed ERK activation by prostaglandin E2 ( PGE2 ) engagement with prostaglandin receptor EP4 , intravenous administration of EP4 agonist activated , *inhibited* [ERK] , and suppressed migration of neutrophils . Negative_regulation EPHB2 PRKCA 15316932 1353588 The phosphorylation of [ERK] and JNK *induced* by overexpression of WT , and the phosphorylation of p38 induced by WT PKCdelta , were regulated by Rho GTPases . Negative_regulation EPHB2 PRKCD 19356729 2081124 Exposure to celastrol inhibited the interaction between immunoglobulin Fc epsilon receptor I ( FcepsilonRIgamma ) and [ERK] and *inhibited* interaction between FcepsilonRIgamma and . Negative_regulation EPHB2 PRL 16840547 1613065 S179D *blocked* [ERK] phosphorylation in response to bFGF , whereas continued coincubation caused a delayed and prolonged activation of ERK . Negative_regulation EPHB2 PRL 16840547 1613068 We conclude that S179D *blocks* bFGF induced [ERK] signaling and yet uses ERK in a different time frame to elevate p21 and activate the extrinsic pathway . Negative_regulation EPHB2 PSMG1 10339498 615926 Our results suggest that ERK is constitutively activated in a majority of acute leukemias , and in addition to the activation of MEK , the hyperexpression of ERK and downregulation of also *contribute* to constitutive [ERK] activation in acute leukemias . Negative_regulation EPHB2 PSTPIP2 24407241 2900618 overexpression also caused enhanced activation of Src family kinases and subsequently *reduced* [ERK] phosphorylation . Negative_regulation EPHB2 PSTPIP2 24407241 2900624 Finally , we found that *repressed* [ERK] signaling , differentiation , and proliferation and verified that PSTPIP2 upregulation repressed megakaryocyte development in primary mouse bone marrow cells . Negative_regulation EPHB2 PTEN 12479095 1023937 [ Role of suppressor encoprotein in IGF-1 *induced* activation of [ERK] in endometrial carcinoma cells ] . Negative_regulation EPHB2 PTEN 12479095 1023942 The objective of this paper was to study extracellular signal regulated kinase ( ERK ) activation in endometrial carcinoma cell line Ishikawa under the stimulation of IGF-1 , and to elucidate the *role* of suppressor encoprotein in activation of [ERK] . Negative_regulation EPHB2 PTEN 19134000 2025391 inhibition by bpV ( phen ) *increased* lung tissue levels of phospho-Akt and [ERK] and but not focal adhesion kinase . Negative_regulation EPHB2 PTEN 20147383 2208286 Loss of Alk5 mediated signaling also stimulated gene expression and *inhibited* [ERK] phosphorylation in vivo . Negative_regulation EPHB2 PTEN 24642271 2930480 Often , [RAS/ERK] signaling is activated by mutation of the RAS or RAF oncogenes , and PI3K/AKT is *activated* by loss of the tumor suppressor . Negative_regulation EPHB2 PTEN 25080557 2953984 In contrast , p190RhoGAP ( RhoA inhibitor ) and ( [Akt/ERK/FAK] *inhibitor* ) were up-regulated in MMP-9 cells . Negative_regulation EPHB2 PTGES3 12223143 987666 HRT , VCR , and Vp16 could inhibit cell proliferation ( 0.28 % 0.08 % , 0.25 % 0.16 % , 0.24 % 0.11 % ) , induce apoptosis ( 21.12 % , 28.83 % , 12.30 % ) , *inhibit* activity , and down-regulate the protein expression of phosphorylated [ERK] . Negative_regulation EPHB2 PTGES3 12674761 1030442 The results showed that HRT , VCR and Vp16 could inhibit cell proliferation , induce apoptosis , *inhibit* activity and down-regulate the protein expression of phosphorylated [ERK] . Negative_regulation EPHB2 PTGS2 15780952 1385413 IL-1alpha activated [ERK] phosphorylation and PD98059 greatly *inhibited* both mRNA expression and PGE ( 2 ) production induced by IL-1alpha in PDL cells . Negative_regulation EPHB2 PTGS2 17334414 1726561 Inhibition of [ERK] activation , but not *inhibition* , completely abolished beneficial effect of G-CSF on cardiac function . Negative_regulation EPHB2 PTGS2 22197135 2544121 Viscolin blocked the expression of iNOS and , and it also *inhibited* the [ERK] for the activation of NF-?B in LPS stimulated RAW 264.7 macrophages . Negative_regulation EPHB2 PTGS2 23834707 2839021 Compound 10o was selective toward melanoma cell line subpanel , and its antiproliferative activity may be attributed to selective inhibition and [ERK] pathway *inhibition* . Negative_regulation EPHB2 PTK2 10859226 704804 Caco-2 motility was inhibited by transfection of ( the COOH-terminal region of FAK ) and PD-98059 , a mitogen activated protein [kinase-ERK] kinase *inhibitor* , but not by SB-203580 , a p38 inhibitor , suggesting that FAK and ERK modulate Caco-2 migration . Negative_regulation EPHB2 PTK2 12089066 959521 In contrast , overexpression did not *prevent* ET-induced [ERK] , JNK , or p70S6K phosphorylation . Negative_regulation EPHB2 PTK2 12456636 1021298 expression disrupted the formation of a v-Src-FAK signaling complex , inhibited p130Cas tyrosine phosphorylation , and *attenuated* v-Src stimulated [ERK] and JNK kinase activation . Negative_regulation EPHB2 PTK2 16461767 1534560 Ectopic expression of the FAK C-terminal domain *attenuated* FAK and [ERK] phosphorylation and micromotion . Negative_regulation EPHB2 PTK2 18669633 1967377 overexpression *blocks* TGF-beta1 induced [ERK] or p38 MAPK activation in the presence , and surprisingly , in the absence of FAK . Negative_regulation EPHB2 PTK2 23508585 2870175 In HCC cells and HUVECs in vitro , IFN/5-FU plus repressed the expression of VEGFR-2 and *repressed* the phosphorylation of VEGFR , Akt , [Erk] , and p38MAPK . Negative_regulation EPHB2 PTK2B 9774361 539709 Role of calcium-sensitive tyrosine kinase in angiotensin II *induced* [Ras/ERK] signaling . Negative_regulation EPHB2 PTK6 23508585 2870176 In HCC cells and HUVECs in vitro , IFN/5-FU plus repressed the expression of VEGFR-2 and *repressed* the phosphorylation of VEGFR , Akt , [Erk] , and p38MAPK . Negative_regulation EPHB2 PTK7 23508585 2870177 In HCC cells and HUVECs in vitro , IFN/5-FU plus repressed the expression of VEGFR-2 and *repressed* the phosphorylation of VEGFR , Akt , [Erk] , and p38MAPK . Negative_regulation EPHB2 PTPN11 10669730 665968 To address the molecular mechanism for the positive *role* of in mediating [Erk] induction , we evaluated the activation of signaling components upstream of Erk in Shp-2 mutant cells . Negative_regulation EPHB2 PTPN11 11085989 810048 Divergent *roles* of in [ERK] activation by leptin receptors . Negative_regulation EPHB2 PTPN11 11085989 810055 We show that a catalytically inactive mutant of *blocks* leptin stimulated [ERK] phosphorylation by the long leptin receptor , ObRb . Negative_regulation EPHB2 PTPN11 11085989 810057 , lacking two C-terminal tyrosine residues , partially *inhibits* [ERK] phosphorylation . Negative_regulation EPHB2 PTPN11 12482708 1024515 Mutant ( but not wt ) expression also *inhibited* NGF stimulated [ERK] activation . Negative_regulation EPHB2 PTPN11 14559821 1153837 Finally , reintroduction of wild-type SHP-2 into SHP-2 mutant cells rescued Erk and p38 activation , and also MMP-2 secretion , whereas dominant negative could *block* the Con A-dependent activation of [Erk] and p38 . Negative_regulation EPHB2 PTPN11 14963045 1235697 Thus , acts as a positive *regulator* of [Erk] activity in AGS cells . Negative_regulation EPHB2 PTPN11 15351743 1292638 Expression of Gab1 PI3K-m in SK-N-MC human primitive neuroectodermal tumor cells expressing wild-type RET markedly impaired Akt phosphorylation , Rac1 activation , and lamellipodia formation that were induced by GDNF whereas expression of Gab1 partially *impaired* [Erk] activation . Negative_regulation EPHB2 PTPN11 23318428 2860723 Expression of with Tyr542/580Phe mutations *resulted* in the suppression of [Erk] activation . Negative_regulation EPHB2 PTPN12 12052829 968793 Overexpression of a binding-defective mutant of p52 ( Shc ) ( S29A ) *enhanced* insulin induced [ERK] activation in insulin receptor overexpressing HIRc-B cells . Negative_regulation EPHB2 PTPN22 22880107 2641781 Sustained activity of , due to the gain-of-function mutation , acts as a dominant negative *regulator* of [ERK] activity leading to blunted cellular responsiveness to environmental stimuli and expression of protective cytokines . Negative_regulation EPHB2 PTPN5 12483215 1032907 We have investigated the *role* of , a striatal enriched tyrosine phosphatase , in the regulation of [ERK] activity in rat neurons . Negative_regulation EPHB2 PTPN5 18708052 2008844 Here , we investigate the *role* of in D2R mediated [ERK] signaling , especially in dopaminergic neuronal development . Negative_regulation EPHB2 PTPN6 10406457 629407 Alanine substitutions further demonstrated that lysine 240 , asparagine 242 , and serine 243 are key residues for AT2 induced apoptosis , [ERK] *inhibition* , and activation . Negative_regulation EPHB2 PTPN6 11566906 863970 These findings suggested that AT(2) *inhibits* [ERK] activity by inducing activity , leading to decreases in AP-1 activity and AP-1 regulated gene expression , in which EGFR dephosphorylation plays an important role via association of SHP-1 . Negative_regulation EPHB2 PTPN7 12592337 1060363 However , antisense inhibition of *enhanced* nuclear translocation of [ERK] and the expression of the megakaryocytic markers CD41 and IL-6 . Negative_regulation EPHB2 PTPRR 10066421 593589 When overexpressed in mammalian cells , wild-type *suppressed* the phosphorylation and activation of [ERK] by epidermal growth factor (EGF) , nerve growth factor (NGF) , and constitutively active MEK1 , a mutant MAPK kinase . Negative_regulation EPHB2 PTX3 11160627 781799 [ERK] activation induced by the PKC activator phorbol myristate acetate was *inhibited* by , PP1 , AG1478 , and calphostin C . Negative_regulation EPHB2 PTX3 11160627 781802 In contrast , activation of [ERK] by lysophosphatidic acid , a Gi-coupled receptor activator , was *inhibited* by , PP1 , and AG1478 , but not by calphostin C . Negative_regulation EPHB2 PTX3 11310854 804869 We examined the upstream regulation of AA-stimulated ERK activation using one of the following signaling pathway inhibitors to pretreat rat cells : the [ERK] kinase *inhibitor* U0126 or PD98059 , the G ( i/o ) inhibitor , the tyrosine kinase inhibitor genistein , the phosphatidylinositol 3-kinase (PI3K) inhibitor wortmannin or LY294002 , the Ca2+ chelator 1,2-bis ( O-aminophenoxy ) ethane-N , N,N ' , N'-tetraacetic acid , or the phospholipase C (PLC) inhibitor U73122 . Negative_regulation EPHB2 PTX3 16251475 1518264 [ERK] phosphorylation was *suppressed* by , suggesting the involvement of G protein coupled receptors ( GPCRs ) in initiating signal transduction by Hcy and leading to ERK activation . Negative_regulation EPHB2 PTX3 17888875 1802482 LPG stimulated [ERK] activity was not *inhibited* by , indicating PTX-sensitive G-proteins independent manner . Negative_regulation EPHB2 PTX3 18468510 1921572 LPG stimulated [ERK] activity was *inhibited* by , indicating the involvement of PTX-sensitive G-proteins . Negative_regulation EPHB2 PTX3 18777088 2020494 We recently reported homocysteine ( Hcy ) -induced [ERK-phosphorylation] was *suppressed* by , which suggested the involvement of GPCRs in initiating signal transduction . Negative_regulation EPHB2 PTX3 19742132 2135056 In addition , , a Gi protein inhibitor , *induced* an inhibitory effect on p38 MAPK , [ERK] phosphorylation and RASMCs migration . Negative_regulation EPHB2 PTX3 21366548 2437968 *blocked* [ERK] phosphorylation , suggesting receptor coupling to G ( i ) or G ( o ) proteins . Negative_regulation EPHB2 PTX3 22716212 2616410 In addition , *inhibited* the phosphorylation of Raf-1 ( p-Raf-1 ) and [ERK] ( p-ERK ) in a dose- and time dependent manner in HSCs . Negative_regulation EPHB2 PTX4 11160627 781797 [ERK] activation induced by the PKC activator phorbol myristate acetate was *inhibited* by , PP1 , AG1478 , and calphostin C . Negative_regulation EPHB2 PTX4 11160627 781800 In contrast , activation of [ERK] by lysophosphatidic acid , a Gi-coupled receptor activator , was *inhibited* by , PP1 , and AG1478 , but not by calphostin C . Negative_regulation EPHB2 PTX4 11310854 804868 We examined the upstream regulation of AA-stimulated ERK activation using one of the following signaling pathway inhibitors to pretreat rat cells : the [ERK] kinase *inhibitor* U0126 or PD98059 , the G ( i/o ) inhibitor , the tyrosine kinase inhibitor genistein , the phosphatidylinositol 3-kinase (PI3K) inhibitor wortmannin or LY294002 , the Ca2+ chelator 1,2-bis ( O-aminophenoxy ) ethane-N , N,N ' , N'-tetraacetic acid , or the phospholipase C (PLC) inhibitor U73122 . Negative_regulation EPHB2 PTX4 16251475 1518263 [ERK] phosphorylation was *suppressed* by , suggesting the involvement of G protein coupled receptors ( GPCRs ) in initiating signal transduction by Hcy and leading to ERK activation . Negative_regulation EPHB2 PTX4 17888875 1802481 LPG stimulated [ERK] activity was not *inhibited* by , indicating PTX-sensitive G-proteins independent manner . Negative_regulation EPHB2 PTX4 18468510 1921571 LPG stimulated [ERK] activity was *inhibited* by , indicating the involvement of PTX-sensitive G-proteins . Negative_regulation EPHB2 PTX4 18777088 2020493 We recently reported homocysteine ( Hcy ) -induced [ERK-phosphorylation] was *suppressed* by , which suggested the involvement of GPCRs in initiating signal transduction . Negative_regulation EPHB2 PTX4 19742132 2135055 In addition , , a Gi protein inhibitor , *induced* an inhibitory effect on p38 MAPK , [ERK] phosphorylation and RASMCs migration . Negative_regulation EPHB2 PTX4 21366548 2437967 *blocked* [ERK] phosphorylation , suggesting receptor coupling to G ( i ) or G ( o ) proteins . Negative_regulation EPHB2 PTX4 22716212 2616409 In addition , *inhibited* the phosphorylation of Raf-1 ( p-Raf-1 ) and [ERK] ( p-ERK ) in a dose- and time dependent manner in HSCs . Negative_regulation EPHB2 RAB11A 20642455 2329289 Using immunofluorescence and immunohistochemical analyses , we show that overexpression of in mutant wing imaginal disc cells *triggers* the induction of apoptosis and activation of JNK and [ERK] . Negative_regulation EPHB2 RABGEF1 16436672 1516528 The results demonstrate that expression of in oropharyngeal SCC *down-regulated* active rap1 , [ERK] activation , and proliferation . Negative_regulation EPHB2 RAC1 11158304 781090 In transfection experiments , dominant negative *inhibited* activation of [ERK] by endothelin 1 , whereas activated V12Rac1 cooperated with c-Raf to activate ERK . Negative_regulation EPHB2 RAC1 11965537 932822 A dominant negative mutant , Rac17N , also *inhibited* the cytokine induced activation of [Erk] as well as Elk-1 . Negative_regulation EPHB2 RAC1 12485852 1025103 Here , we describe that the inhibition of or Cdc42 signaling *leads* to MAPK [ERK] activation via a pathway involving PI(3)K , Akt , Raf , and MEK , but not Ras . Negative_regulation EPHB2 RAC1 23817184 2815709 [ERK] was activated under the basal conditions in MSTO-211H cells , and the activation was *prevented* by inhibitors for PI3 kinase , PDK1 , Akt , and Rac1 or by knocking-down PI3 kinase , PDK1 , Akt , and . Negative_regulation EPHB2 RAC2 11965537 932823 A dominant negative mutant , Rac17N , also *inhibited* the cytokine induced activation of [Erk] as well as Elk-1 . Negative_regulation EPHB2 RAC3 11965537 932824 A dominant negative mutant , Rac17N , also *inhibited* the cytokine induced activation of [Erk] as well as Elk-1 . Negative_regulation EPHB2 RAD50 10476970 642773 This decrease in GTP bound *activates* [ERK/MAPK] . Negative_regulation EPHB2 RAD50 11228165 788458 Furthermore , overexpression of *enhanced* p38 activity but not [ERK] or JNK activity . Negative_regulation EPHB2 RAD50 11340161 812420 In NIH 3T3 cells , is *required* not only for cAMP 's inhibition of [ERK] activation but for inhibition of cell proliferation and mitogenesis as well . Negative_regulation EPHB2 RAD50 11479306 860616 Moreover , inhibition of by a Rap1 GTPase activating protein-1 also *resulted* in a decrease in [ERK] and Akt phosphorylation , which was not further decreased by cAMP , suggesting that cAMP inhibits ERK and Akt by inhibiting Rap1 . Negative_regulation EPHB2 RAD50 11479306 860672 The *role* of in [ERK] and Akt activity was further demonstrated by our observation that an active form of Epac , which activated Rap1 in the absence of cAMP , increased ERK and Akt phosphorylation . Negative_regulation EPHB2 RAD50 16507992 1529665 We confirm that the PKA independent activation of by Epac1 activates a perinuclear pool of Rap1 and that this does not *result* in [ERK] activation . Negative_regulation EPHB2 RAF1 10026138 591243 Upstream of [ERK] , Shc was shown to be activated , but its downstream and ERK were *inhibited* . Negative_regulation EPHB2 RAF1 10958675 724912 PI3-kinase inhibitors enhanced CSF-1 stimulated A-Raf and c-Raf-1 activities , and dominant negative A-Raf but not dominant negative *reduced* CSF-1 provoked [ERK] activation , suggesting that A-Raf mediates a part of the stimulatory signal from Ras to MEK/ERK , acting in parallel to PI3-kinase . Negative_regulation EPHB2 RAF1 11279222 819652 Pertussis toxin , , and PD98059 *prevented* both the serum- and thrombin induced second phase [ERK] phosphorylation and SM-MHC promoter activation . Negative_regulation EPHB2 RAF1 11971957 933705 Using RafS259 mutants we also demonstrate that is the sole *target* for PKA inhibition of [ERK] and ERK induced gene expression , and that Raf-1 inhibition is mediated mainly through serine 259 phosphorylation . Negative_regulation EPHB2 RAF1 15534860 1387372 The suppression of Ser-259 phosphorylation *caused* the induction of Raf-1 kinase activity , as well as [hyper-ERK] phosphorylation . Negative_regulation EPHB2 RAF1 17045653 1666565 The classic Ras mediated pathway of ERK1/2 activation by LPS was confirmed when the specific inhibitor , GW 5074 , and the MEK1/2 inhibitor , U0126 , both reduced [ERK] *activation* by 51-60 % . Negative_regulation EPHB2 RAF1 18771726 1980329 We demonstrated here , that PTPIP51 could regulate ERK activity on Raf level , since MEK inhibitor and dominant negative but not Ras could *inhibit* the [ERK] activation induced by PTPIP51 . Negative_regulation EPHB2 RAF1 22572848 2625049 Coexpression of ZnT-1 and nonactive *blocked* the ZnT-1 mediated [ERK] phosphorylation and abolished the ZnT-1 induced augmentation of I ( caT ) . Negative_regulation EPHB2 RAF1 22700586 2633804 This work describes a model wherein unopposed IGF-I promotes high ERK/p38 activity ratios favoring proliferation , whereas BDNF signals a transition to differentiation by decreasing the ERK/p38 activity ratio without completely inhibiting [ERK] , which *involves* the direct inhibition of by p38 . Negative_regulation EPHB2 RANBP9 23118896 2696007 Transient and stable down-regulation of *stimulated* [ERK] phosphorylation , leading to Bcl-2 up-regulation , while re-expression of RanBPM reversed these effects . Negative_regulation EPHB2 RANBP9 23118896 2696008 was found to *inhibit* MEK and [ERK] activation induced by ectopic expression of active RasV12 . Negative_regulation EPHB2 RANBP9 23118896 2696016 Activation of [ERK] by active c-Raf was also *prevented* by . Negative_regulation EPHB2 RAPGEF3 16507992 1529660 We confirm that the PKA independent activation of Rap1 by activates a perinuclear pool of Rap1 and that this does not *result* in [ERK] activation . Negative_regulation EPHB2 RASA1 11585923 866389 Inactivation of Ras , induced by ephrin B1 stimulation of NG108 neuronal cells , requires [EphB2] tyrosine kinase activity and is *blocked* by a truncated form of p120-Ras ( p120-RasGAP ) , suggesting that EphB2 signals through the SH2 domain protein p120-RasGAP to inhibit the Ras-MAPK pathway . Negative_regulation EPHB2 RASA1 16436672 1516529 The results demonstrate that expression of in oropharyngeal SCC *down-regulated* active rap1 , [ERK] activation , and proliferation . Negative_regulation EPHB2 RASA1 23133361 2696561 The model confirms that phagocytosis associated changes in the composition of the cell membrane can inhibit ERK activity and predicts that Akt and synergize to *inhibit* [ERK] . Negative_regulation EPHB2 RASGRF1 23145787 2722836 In the present study we characterized the *role* of in Ca2+ and [Ras?ERK] signalling after IL-1 stimulation . Negative_regulation EPHB2 RASGRF2 23145787 2722837 In the present study we characterized the *role* of in Ca2+ and [Ras?ERK] signalling after IL-1 stimulation . Negative_regulation EPHB2 RASGRP1 10807788 692346 Overexpression of in T cells *enhanced* [TCR-Ras-Erk] signaling and augmented interleukin-2 secretion in response to calcium ionophore plus DAG analogues phorbol ester myristate or bryostatin-1 . Negative_regulation EPHB2 RASGRP2 10807788 692347 Overexpression of in T cells *enhanced* [TCR-Ras-Erk] signaling and augmented interleukin-2 secretion in response to calcium ionophore plus DAG analogues phorbol ester myristate or bryostatin-1 . Negative_regulation EPHB2 RASGRP3 10807788 692344 Overexpression of in T cells *enhanced* [TCR-Ras-Erk] signaling and augmented interleukin-2 secretion in response to calcium ionophore plus DAG analogues phorbol ester myristate or bryostatin-1 . Negative_regulation EPHB2 RASGRP4 10807788 692345 Overexpression of in T cells *enhanced* [TCR-Ras-Erk] signaling and augmented interleukin-2 secretion in response to calcium ionophore plus DAG analogues phorbol ester myristate or bryostatin-1 . Negative_regulation EPHB2 RBL2 10329689 613784 Grb2 with a deleted carboxyl-terminal Src homology 3 domain partially blocked Pyk2 induced ERK and JNK pathways , whereas expression of dominant interfering mutants of or Crk specifically *inhibited* JNK but not [ERK] activation by Pyk2 . Negative_regulation EPHB2 RBL2 12456636 1021299 FRNK expression disrupted the formation of a v-Src-FAK signaling complex , *inhibited* tyrosine phosphorylation , and attenuated v-Src stimulated [ERK] and JNK kinase activation . Negative_regulation EPHB2 REG1A 18388567 1907168 This study examined the *role* of in suppressed T-cell p-38 , [ERK] , and cytokine production after EtOH intoxication and burn injury . Negative_regulation EPHB2 RELA 15073167 1257641 By contrast , cisplatin , either alone or with [MEK/ERK] *inhibitors* , induced little activation in antisense PP4 transfected cells . Negative_regulation EPHB2 RELA 17189385 1662757 Inhibition of by overexpression of mutant IkappaB *increased* [ERK] phosphorylation . Negative_regulation EPHB2 RELA 17189385 1662775 Taken together , these results suggest that *inhibits* [ERK] activation to enhance cell survival during the development of tumor adaptive radioresistance . Negative_regulation EPHB2 RELA 19823174 2187269 Sulfur dioxide donor significantly downregulated Raf-1 , mitogen activated protein kinase kinase-1 ( MEK-1 ) and [p-ERK/ERK] , and *inhibited* pulmonary vascular smooth muscle cell proliferation , collagen remodeling and pulmonary vascular endothelial cell , and intercellular adhesion molecule 1 ( ICAM-1 ) expressions . Negative_regulation EPHB2 RELA 20403072 2282159 [MEK/ERK] inhibition also *induced* I-kappaB phosphorylation and enhanced binding activity , leading to expression of cellular inhibitors of apoptosis protein 2 ( c-IAP2 ) , a known nuclear factor-kappaB (NF-kappaB) regulated endogenous anti-apoptotic molecule . Negative_regulation EPHB2 RELA 21426933 2427293 Downregulation of uPA and uPAR , simultaneously by transfecting the cancer cells with bi-cistronic siRNA expressing plasmid ( pU ) *inhibited* radiation induced [ERK] activation , nuclear translocation of , NF-?B DNA binding activity , and MCP-1 expression . Negative_regulation EPHB2 RELA 9092580 422120 Inhibition of tyrosine kinase activity with genistein ( 10 microg/ml ) as well as selective MAP kinase inhibition with the MEK-1 inhibitor PD98059 abolished the VLA-4 dependent [ERK] tyrosine phosphorylation , *inhibited* nuclear binding , and abrogated tissue factor expression induced by both VLA-4 cross linking and adhesion to fibronectin in THP-1 cells and human peripheral blood monocytes . Negative_regulation EPHB2 RELB 17705129 1789017 YopJ injection prevents up-regulation of the NF-kappaB and *inhibits* [MAPK/ERK] activation -- both having key roles in DC differentiation . Negative_regulation EPHB2 RGS14 19878719 2184486 selectively *inhibits* PDGF- , but not EGF- or serum stimulated [Erk] phosphorylation . Negative_regulation EPHB2 RGS2 16517124 1597944 We also examined hypertrophy associated MAP kinase pathways , and overexpression completely *prevented* the activation of [ERK] by PE . Negative_regulation EPHB2 RGS4 10936173 720604 Activation of extracellular signal regulated kinase ( [ERK] ) and Akt by human serotonin 5-HT(1B) receptors in transfected BE ( 2 ) -C neuroblastoma cells is *inhibited* by . Negative_regulation EPHB2 RGS4 22193724 2599707 overexpressed in the dSTR coimmunoprecipitated with mGluR5 receptors and *suppressed* both behavioral activity and [phospho-ERK] levels induced by DHPG . Negative_regulation EPHB2 RGS4 22193724 2599708 overexpression or the mGluR5 antagonist , 3- ( ( 2-methyl-4-thiazolyl ) ethynyl ) pyridine ( MTEP ) , *attenuated* amphetamine induced [phospho-ERK] ( but not phospho-Akt ) levels . Negative_regulation EPHB2 RHO 12773570 1095223 Inhibition of either MLCK or Rho kinase blocked sustained [ERK] signaling , but only kinase inhibition *allowed* for the induction of cyclin D1 and activation of cdk4 via Rac/Cdc42 . Negative_regulation EPHB2 RHO 16322093 1533067 Lbc stably transfected hepatocarcinoma cells exhibit increased proliferation and levels of [ERK] and cyclin D1 activation , which are *blocked* by a inhibitor . Negative_regulation EPHB2 RHOA 12874183 1120960 inhibition *increased* levels of phosphorylated [ERK] in the cell nucleus . Negative_regulation EPHB2 RHOA 23770849 2937839 Here , we show that inhibition of is *sufficient* to upregulate [ERK] activation in epithelial cells . Negative_regulation EPHB2 RHOA 9171350 433393 While the stimulation of [Erk] by alpha6beta4 was *suppressed* by dominant negative Shc , Ras and , the activation of Jnk was inhibited by dominant negative Ras and Rac1 and by the phosphoinositide 3-kinase inhibitor Wortmannin . Negative_regulation EPHB2 RHOB 10770919 698941 Here we demonstrate that both and RhoB-GG inhibit anchorage dependent and -independent growth , induce apoptosis , *inhibit* constitutive activation of [Erk] and insulin-like growth factor-1 stimulation of Akt , and suppress tumor growth in nude mice . Negative_regulation EPHB2 RICTOR 20512842 2270546 In this report , we focused on studying the *role* of mTORC1 and in rapamycin mediated Akt and [ERK] phosphorylation , and the antitumor effect of rapamycin in cancer cells in combination with Akt and ERK inhibitors . Negative_regulation EPHB2 RIT1 18332868 1925106 Consistently , VprBP depletion abolished the in vivo interaction of Merlin and , which resulted in Merlin stabilization and *inhibited* [ERK] and Rac activation . Negative_regulation EPHB2 RIT1 18388731 1893225 Furthermore , dominant negative *inhibited* Goalpha induced neurite outgrowth and [Erk] phosphorylation in Neuro2a cells . Negative_regulation EPHB2 RNF19A 16706195 1496611 In this paper we have explored the role of different kinase pathways of signal transduction in proliferation control of E1A + Ras transformants , using specific *inhibitors* of MAP-kinases [ERK] , JNK , and PI3-kinase . Negative_regulation EPHB2 RNF19A 17637226 1770763 it also promoted the activation of [p-ERK] during the early phase of reperfusion but *inhibited* the activation of p-JNK1/2 and following the 30-minute , 1-hour and 3-hour intervals of reperfusion . Negative_regulation EPHB2 ROCK1 21166955 2378666 Thus , it is suggested that the anti-angiogenic effect of HA1077 may be due to the combination of inhibition and mitogen activated protein kinase kinase ( MEK ) [/ERK] pathway *inhibition* . Negative_regulation EPHB2 ROCK1 21849669 2495961 RhoA , ROCK inhibition , or RhoA , , ROCK2 , mDia1 , and FAK reduction by siRNA *blocked* deformation induced nuclear [ERK] phosphorylation without preventing ERK phosphorylation in the cytoplasmic protein fraction . Negative_regulation EPHB2 ROCK2 21166955 2378667 Thus , it is suggested that the anti-angiogenic effect of HA1077 may be due to the combination of inhibition and mitogen activated protein kinase kinase ( MEK ) [/ERK] pathway *inhibition* . Negative_regulation EPHB2 ROCK2 21849669 2495962 RhoA , ROCK inhibition , or RhoA , ROCK1 , , mDia1 , and FAK reduction by siRNA *blocked* deformation induced nuclear [ERK] phosphorylation without preventing ERK phosphorylation in the cytoplasmic protein fraction . Negative_regulation EPHB2 RPS6KA6 15121846 1242160 We demonstrate that *inhibits* the transcriptional activation of specific targets of RTK signaling as well as the activation of [ERK] . Negative_regulation EPHB2 RPTOR 20512842 2270547 In this report , we focused on studying the *role* of and mTORC2 in rapamycin mediated Akt and [ERK] phosphorylation , and the antitumor effect of rapamycin in cancer cells in combination with Akt and ERK inhibitors . Negative_regulation EPHB2 RPTOR 22715163 2634056 Lovastatin alone significantly reduced MPC and MTT cell viability at therapeutically relevant doses and *inhibited* both [ERK] and AKT signalling , but increased signalling . Negative_regulation EPHB2 RRM2B 19398949 2089499 Ribonucleotide reductase small subunit *suppresses* [MEK-ERK] activity by binding to ERK kinase 2 . Negative_regulation EPHB2 S1PR1 17932312 1825546 Using siRNA , we found that the effect of APC on the [EGR-1/ERK] signaling required for TRAIL inhibition was *dependent* on the receptor and S1P1 kinase . Negative_regulation EPHB2 S1PR1 21769916 2494856 A G-protein coupled receptor inhibitor , pertussis toxin , and and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Negative_regulation EPHB2 SAA1 19307752 2087011 LL-37 caused a dramatic inhibition of [ERK] and p38 MAPK activity , which is *induced* by . Negative_regulation EPHB2 SCRIB 20622900 2321778 In human keratinocytes , loss of results in elevated phospho-ERK levels and concomitant *increased* nuclear translocation of [phospho-ERK] . Negative_regulation EPHB2 SEMA4D 19444311 2090602 M-Ras ( Q71L ) stimulated extracellular signal regulated kinase ( ERK ) activation , inducing dendrite growth , whereas suppressed ERK activity and down-regulation of [ERK] was *required* for a Sema4D induced reduction of dendrite growth . Negative_regulation EPHB2 SERPINA12 23135225 2735654 stimulated the phosphorylation of ERK , and pretreatment of hOBs with the ERK inhibitor PD98059 *blocked* the vaspin induced activation of [ERK] , however , vaspin did not stimulate the phosphorylation of p38 , JNK or Akt . Negative_regulation EPHB2 SERPINE1 24500480 2914031 Pg LPS also induced [ERK] , p38 , and JNK activation , and Pg LPS induced expression was *inhibited* by ERK/p38/JNK inhibitor pretreatment . Negative_regulation EPHB2 SETD2 23869238 2817634 BBR also downregulated and VEGF expression and *inhibited* Akt and [ERK] phosphorylation . Negative_regulation EPHB2 SF1 17312106 1699610 Only significantly *inhibited* [ERK] activation induced by P3C , which acts via TLR2/1 heterodimers . Negative_regulation EPHB2 SFN 20642839 2297543 *inhibited* phosphorylation of AKT and [ERK] , and activated FOXO transcription factors , leading to cell cycle arrest and apoptosis . Negative_regulation EPHB2 SHB 20585392 2280551 Moreover , the absence of *enhanced* [ERK] ( extracellular-signal regulated kinase ) and RSK ( ribosomal S6 kinase ) signaling in oocytes and these effects were paralleled by an increased ribosomal protein S6 phosphorylation and activation . Negative_regulation EPHB2 SHBG 16700004 1560533 After interacting with a specific binding site on breast cancer cell membranes , activates a specific pathway , and by cAMP induction , *inhibits* estradiol mediated activation of [ERK] . Negative_regulation EPHB2 SHC1 14576154 1199908 Non-redundant *role* of in [Erk] activation by cytoskeletal reorganization . Negative_regulation EPHB2 SHC1 23584453 2778476 Interaction with *prevents* aberrant [Erk] activation in the absence of extracellular stimuli . Negative_regulation EPHB2 SHC1 23832324 2808977 Conversely , silencing *reduced* [ERK] and S6K1 signaling and Arg-II levels and cell senescence/apoptosis . Negative_regulation EPHB2 SHC1 9165038 432222 In contrast , expression of the MAP kinase phosphatase ( MKP-1 ) completely prevented [ERK] activation but did not *inhibit* the serine phosphorylation of 66-kDa . Negative_regulation EPHB2 SHH 17299056 1711308 FGF mediated inhibition of responses *requires* activation of FGF receptors and of [ERK] and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation EPHB2 SHOC2 24711380 2935542 It is known that Erbin *inhibits* Ras mediated activation of the extracellular signal regulated kinase ( [ERK] ) by binding to ( Shoc2 ) . Negative_regulation EPHB2 SIM2 21080865 2349689 The Hydroxymethylglutaryl coenzyme A reductase inhibitor *prevents* the activation of [ERK] in SHR to mediate regression of myocardial hypertrophy in SHR . Negative_regulation EPHB2 SIRPA 18218778 1864073 Knocking down expression in cultured cells *resulted* in increased [Erk] activation , and partially knocking down Erk reversed the increased anoikis resistance of Bit1 knockdown . Negative_regulation EPHB2 SKAP1 18320039 1881079 RNAi knock down ( KD ) of SKAP-55 in T-cell lines also showed an increase in p21(ras) activation , while over-expression of *inhibited* activation of [ERK] and its transcriptional target ELK . Negative_regulation EPHB2 SKAP1 18320039 1881082 Firstly , SKAP-55 bound to RasGRP1 via its C-terminus , while secondly , the loss of binding abrogated *inhibition* of [ERK] and ELK activation . Negative_regulation EPHB2 SKP2 18519678 1918590 Here , we evaluated the effects of the functional interactions of ERK proteins with dual-specificity phosphatase 1 (DUSP1) , a specific *inhibitor* of [ERK] , and S-phase kinase associated protein 2 ( ) /CDC28 protein kinase 1b (CKS1) ubiquitin ligase complex in human hepatocellular carcinoma ( HCC ) . Negative_regulation EPHB2 SLC8A1 12502566 1026777 Inhibition of ERK with the MEK inhibitor UO126 , the ERK protein phosphatase MKP-3 , inhibited [ERK] activation , but only *inhibited* alpha-adrenergic induced upregulation by 30 % . Negative_regulation EPHB2 SLC9A1 14600156 1187525 Receptor independent activation of by acute acid loading of RASM cells *resulted* in the rapid phosphorylation of [ERK] , which could be blocked by pharmacological inhibitors of NHE-1 or by isotonic replacement of sodium , closely linking the proton transport function of NHE-1 to ERK activation . Negative_regulation EPHB2 SLC9A1 17167226 1662035 Additionally , inhibition of *resulted* in [ERK] inhibition as well . Negative_regulation EPHB2 SLC9A1 17982256 1821109 Here , we show , using a combination of biochemical and molecular biology approaches , that three MAPKs exhibit unique interrelationships with the Na ( + ) /H ( + ) exchanger , NHE1 , after osmotic cell shrinkage : Extracellular Signal Regulated Kinase ( ERK1/2 ) is inhibited in an NHE1 dependent , pH(i) independent manner , c-Jun N-terminal kinase ( JNK1/2 ) is stimulated , in part through NHE1 mediated intracellular alkalinization , and p38 MAPK is activated in an NHE1 independent manner , and contributes to activation and [ERK] *inhibition* . Negative_regulation EPHB2 SMAD1 15019950 1221170 A reporter assay using NGF stimulated PC12 cells demonstrated that [MEK/Erk/Elk-driven] transcriptional activity was *inhibited* by and by PD98059 . Negative_regulation EPHB2 SMAD3 20060825 2218483 Halofuginone enhanced Akt , [MAPK/ERK] and p38 MAPK phosphorylation and *inhibited* phosphorylation in myotubes , all of which are crucial for myotube fusion . Negative_regulation EPHB2 SMAD4 10962574 727225 These results suggest that acts *inhibiting* Ras dependent [Erk] signalling activity in Ras transformed keratinocytes . Negative_regulation EPHB2 SMAD5 15019950 1221171 A reporter assay using NGF stimulated PC12 cells demonstrated that [MEK/Erk/Elk-driven] transcriptional activity was *inhibited* by and by PD98059 . Negative_regulation EPHB2 SMAD7 17096210 1685768 Moreover , we observed that overexpression of *restored* TGF-beta1 mediated [ERK] phosphorylation in Smad4 knockdown cells but not in TbetaRII knockdown cells . Negative_regulation EPHB2 SMARCA2 20371669 2273386 Furthermore , treatment with 3MA markedly down-regulated capsaicin induced p38 activation and LC3 conversion , and completely *down-regulated* [ERK] activation and led to LC3II accumulation . Negative_regulation EPHB2 SMARCA4 20371669 2273387 Furthermore , treatment with 3MA markedly down-regulated capsaicin induced p38 activation and LC3 conversion , and completely *down-regulated* [ERK] activation and led to LC3II accumulation . Negative_regulation EPHB2 SMARCB1 20371669 2273388 Furthermore , treatment with 3MA markedly down-regulated capsaicin induced p38 activation and LC3 conversion , and completely *down-regulated* [ERK] activation and led to LC3II accumulation . Negative_regulation EPHB2 SMARCC1 20371669 2273389 Furthermore , treatment with 3MA markedly down-regulated capsaicin induced p38 activation and LC3 conversion , and completely *down-regulated* [ERK] activation and led to LC3II accumulation . Negative_regulation EPHB2 SMARCC2 20371669 2273390 Furthermore , treatment with 3MA markedly down-regulated capsaicin induced p38 activation and LC3 conversion , and completely *down-regulated* [ERK] activation and led to LC3II accumulation . Negative_regulation EPHB2 SMARCD1 20371669 2273391 Furthermore , treatment with 3MA markedly down-regulated capsaicin induced p38 activation and LC3 conversion , and completely *down-regulated* [ERK] activation and led to LC3II accumulation . Negative_regulation EPHB2 SMARCE1 20371669 2273392 Furthermore , treatment with 3MA markedly down-regulated capsaicin induced p38 activation and LC3 conversion , and completely *down-regulated* [ERK] activation and led to LC3II accumulation . Negative_regulation EPHB2 SNAP25 15120632 1242038 , at 0.5-4 mM , significantly and dose-dependently *inhibited* angiogenesis , PKC activity , and [ERK] and c-Jun phosphorylation up to 80 % , 83 % , and 63 % and 73 % , respectively . Negative_regulation EPHB2 SNORD102 20049872 2200701 PDTC , an NF-kappaB inhibitor , blocked the osteogenic differentiation induced by TNF-alpha and TLR-ligands , but , an [ERK] *inhibitor* , did not . Negative_regulation EPHB2 SNX1 19035474 1998586 Growth factor activation of [ERK] and JNK signaling was significantly *reduced* by . Negative_regulation EPHB2 SNX2 19035474 1998587 Growth factor activation of [ERK] and JNK signaling was significantly *reduced* by . Negative_regulation EPHB2 SNX4 19035474 1998588 Growth factor activation of [ERK] and JNK signaling was significantly *reduced* by . Negative_regulation EPHB2 SOAT1 11331873 808925 A tyrosine mutant of SOCS-3 still blocks phosphorylation , but also strongly *inhibits* IL-2 dependent activation of [ERK] and cell proliferation . Negative_regulation EPHB2 SOAT1 12687404 1157152 Intriguingly , recent in vivo studies indicated that the SHP-2 binding site- and YXXQ mediated pathways through gp130 are not mutually exclusive but affect each other : a mutation at the SHP-2 binding site prolongs STAT3 activation , and a loss of activation by gp130 truncation *leads* to sustained [SHP-2/ERK] MAPK phosphorylation . Negative_regulation EPHB2 SOCS1 16122907 1507322 overexpression *inhibited* sustained , but not transient , [ERK] phosphorylation . Negative_regulation EPHB2 SOCS3 11331873 808926 A tyrosine mutant of still blocks STAT phosphorylation , but also strongly *inhibits* IL-2 dependent activation of [ERK] and cell proliferation . Negative_regulation EPHB2 SOCS6 14707129 1219154 did not *impair* [ERK] and p38 activation by other stimuli . Negative_regulation EPHB2 SOD1 16572112 1556003 or PD98059 pretreatment *reduced* high-glucose and AGE promotion of [ERK] and c-Jun activation . Negative_regulation EPHB2 SOD1 18036352 1860835 A pretreatment with NAC or catalase , but not , *attenuated* the phosphorylation of [ERK] , JNK , and p38 kinase by heat shock . Negative_regulation EPHB2 SOD1 18765227 1975639 The Cu-Zn ( SOD1 ) *inhibits* [ERK] phosphorylation by muscarinic receptor modulation in rat pituitary GH3 cells . Negative_regulation EPHB2 SOD1 22335188 2586610 [ERK] upregulation was *blocked* by BQ-123 and . Negative_regulation EPHB2 SOD2 16572112 1556004 or PD98059 pretreatment *reduced* high-glucose and AGE promotion of [ERK] and c-Jun activation . Negative_regulation EPHB2 SOD2 18036352 1860836 A pretreatment with NAC or catalase , but not , *attenuated* the phosphorylation of [ERK] , JNK , and p38 kinase by heat shock . Negative_regulation EPHB2 SOD2 18765227 1975640 The Cu-Zn ( SOD1 ) *inhibits* [ERK] phosphorylation by muscarinic receptor modulation in rat pituitary GH3 cells . Negative_regulation EPHB2 SOD2 22335188 2586611 [ERK] upregulation was *blocked* by BQ-123 and . Negative_regulation EPHB2 SOD3 16572112 1556005 or PD98059 pretreatment *reduced* high-glucose and AGE promotion of [ERK] and c-Jun activation . Negative_regulation EPHB2 SOD3 18036352 1860837 A pretreatment with NAC or catalase , but not , *attenuated* the phosphorylation of [ERK] , JNK , and p38 kinase by heat shock . Negative_regulation EPHB2 SOD3 18765227 1975641 The Cu-Zn ( SOD1 ) *inhibits* [ERK] phosphorylation by muscarinic receptor modulation in rat pituitary GH3 cells . Negative_regulation EPHB2 SOD3 22335188 2586612 [ERK] upregulation was *blocked* by BQ-123 and . Negative_regulation EPHB2 SOS1 22761938 2623319 LPS induces ubiquitin mediated degradation of DOK3 leading to degradation and *inhibition* of [ERK] activation . Negative_regulation EPHB2 SPHK1 11258664 794519 Overexpression of did not additionally *increase* the bradykinin induced [ERK/MAP] kinase activity , indicating a permissive rather than activating role of sphingosine 1-phosphate in B2 receptor mediated mitogenic signaling . Negative_regulation EPHB2 SPHK2 11258664 794520 Overexpression of did not additionally *increase* the bradykinin induced [ERK/MAP] kinase activity , indicating a permissive rather than activating role of sphingosine 1-phosphate in B2 receptor mediated mitogenic signaling . Negative_regulation EPHB2 SPRED1 15465815 1342219 In IL-3 dependent Ba/F3 cells expressing c-kit , forced expression of *resulted* in a reduced proliferation rate and [ERK] activation in response to not only SCF but also IL-3 . Negative_regulation EPHB2 SPRED1 16115197 1448850 Furthermore , forced expression of exogenous in Cav-1 expressing cells further *suppressed* proliferation and [ERK] activation . Negative_regulation EPHB2 SPRED1 16115197 1448851 These data suggest that *inhibits* [ERK] activation in collaboration with Cav-1 . Negative_regulation EPHB2 SPRED2 23169297 2740796 In functional assays , overexpression *reduced* [ERK] phosphorylation and inhibited prostate cancer cell proliferation and migration in response to different growth factors and full-media stimulation ( P < 0.001 ) . Negative_regulation EPHB2 SPRY1 17388787 1735559 Expression of , SPRY2 , SPRY3 and SPRY4 in HEK293T cells transfected with RET and GDNF receptor family alpha1 ( GFRalpha1 ) genes significantly *reduced* sustained [ERK] activation as well as ELK-1 activation . Negative_regulation EPHB2 SPRY1 18582454 1946683 Overexpression of in chondrocytes *causes* attenuated FGFR ubiquitination and sustained [ERK] activation resulting in chondrodysplasia . Negative_regulation EPHB2 SPRY1 18582454 1946690 In addition , overexpression of *resulted* in sustained [ERK] activation and increased expression of p21 and STAT1 . Negative_regulation EPHB2 SPRY2 15313890 1285676 These data suggest that , an *inhibitor* of [ERK] signaling , may be bypassed in melanoma cells either by down-regulation of its expression in WT BRAF cells , or by the presence of the BRAF mutation . Negative_regulation EPHB2 SPRY2 16888801 1672680 *inhibits* FGF dependent [ERK] activation and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Negative_regulation EPHB2 SPRY2 18048363 1852461 In the parental , non-H-Ras transformed fibroblasts , expression of resulted in the *inhibition* of H-Ras and [ERK] activation , suggesting that the positive effect of Spry2 in tumor formation is specific to H-Ras transformation . Negative_regulation EPHB2 SPRY2 20683950 2299064 In HCC cell lines , overexpression *inhibits* c-Met induced cell proliferation as well as [ERK] and AKT activation , whereas loss of Spry2 potentiates c-Met signaling . Negative_regulation EPHB2 SPRY2 20881000 2347109 Repression of *potentiated* the nickel induced [ERK] phosphorylation , and forced expression of Spry2 in BEAS-2B cells decreased the nickel induced ERK phosphorylation and significantly suppressed nickel induced anchorage independent growth . Negative_regulation EPHB2 SPRY2 23434594 2749016 Here , we show that deficiency alone *triggers* activation of AKT and [ERK] , but this is insufficient to drive tumorigenesis . Negative_regulation EPHB2 SPRY3 17388787 1735560 Expression of SPRY1 , SPRY2 , and SPRY4 in HEK293T cells transfected with RET and GDNF receptor family alpha1 ( GFRalpha1 ) genes significantly *reduced* sustained [ERK] activation as well as ELK-1 activation . Negative_regulation EPHB2 SPRY4 17388787 1735561 Expression of SPRY1 , SPRY2 , SPRY3 and in HEK293T cells transfected with RET and GDNF receptor family alpha1 ( GFRalpha1 ) genes significantly *reduced* sustained [ERK] activation as well as ELK-1 activation . Negative_regulation EPHB2 SRC 11278310 810918 In contrast , inhibition of Ras or *had* no effect on the sustained [ERK] activity , which was critically dependent on phosphatidylinositol 3-kinase . Negative_regulation EPHB2 SRC 15166244 1273414 The tyrosine kinase inhibitor 4-amino-5- ( 4-chlorophenyl ) -7- ( t-butyl ) pyrazolol [ 3,4-d ] pyrimidine *had* no effect on Tau-Cl induced EGF receptor or [ERK] activation . Negative_regulation EPHB2 SRC 15564375 1341424 FRS2 dependent activation is *required* for fibroblast growth factor receptor induced phosphorylation of Sprouty and suppression of [ERK] activity . Negative_regulation EPHB2 SRC 22532027 2608234 In addition , overexpression of as well as treatment with ATO could *stimulate* [EGFR-Y845/ERK] phosphorylation , p21 expression , and cellular arrest/apoptosis , which could be attenuated by pretreatment with apocynin or knockdown of p67(phox) . Negative_regulation EPHB2 SRC 22931352 2697628 The activation of PKCd by daidzein was attenuated in the presence of a Src kinase inhibitor , and that of [ERK] by daidzein was diminished in the *presence* of either a or PKCd inhibitor . Negative_regulation EPHB2 SRC 24440771 2912777 Although the levels of phosphorylated were up-regulated simultaneously with ERK reactivation , neither [ERK] suppression using U0126 nor an ERK-specific siRNA *induced* Src phosphorylation . Negative_regulation EPHB2 SRL 16298629 1484820 above 1 nmol/L *inhibited* PDGF induced VSMC proliferation and collagen synthesis but not PDGF induced fibronectin secretion , cellular ROS , and activation of [ERK] and p38 MAPK . Negative_regulation EPHB2 STAT1 23274199 2763908 Western blot analysis revealed that the tocilizumab enhanced the interferon induced phosphorylation of and *inhibited* SOCS3 expression and the phosphorylation of both STAT3 and [ERK] . Negative_regulation EPHB2 STAT3 10899938 712569 The IL-6 induced inhibition of PTP and LTP was accompanied by a simulation of tyrosine phosphorylation and an *inhibition* of [MAPK/ERK] dual phosphorylation , in the absence of changes in the state of activation of SAPK/JNK . Negative_regulation EPHB2 STAT3 15805288 1390982 Expression of constitutively active MEK-1 caused an increase of [ERK] activity and *inhibited* ( ( Tyr705 ) ) phosphorylation . Negative_regulation EPHB2 STAT3 16788692 1599450 *attenuates* EGFR mediated [ERK] activation and cell survival during oxidant stress in mouse proximal tubular cells . Negative_regulation EPHB2 STAT3 16788692 1599453 Inhibition of JAK2 or *lead* to increased [ERK] activation and survival of TKPTS cells during severe oxidative stress . Negative_regulation EPHB2 STAT3 16788692 1599455 Our data suggest a *role* of tyrosine phosphorylated in the suppression of [ERK] activation . Negative_regulation EPHB2 STAT3 20395410 2287864 VEGF *induced* [ERK] and AKT phosphorylation ( indicative of differentiation ) , while inhibiting phosphorylation of ( indicative of ` stemness ' ) . Negative_regulation EPHB2 STAT3 22313262 2600251 Inhibition of in fibroblasts *potentiated* IL-6R induced [ERK] phosphorylation and vice versa . Negative_regulation EPHB2 STAT3 22648519 2686841 Further analysis demonstrated that ISL not only downregulated IL-6 expression but also significantly decreased levels of phosphorylated ERK and and could *inhibit* phosphorylation levels of [ERK] and STAT3 induced by recombinant human IL-6 , which are critical signaling proteins in IL-6 signaling regulation networks . Negative_regulation EPHB2 STAT3 23114032 2717426 Exposure of SHED to EGM2-MV supplemented with VEGF *induced* potent activation of [ERK] and Akt signaling , while it inhibited phosphorylation of . Negative_regulation EPHB2 STAT5A 23560534 2782967 Western blot confirmed that ruxolitinib blocked [ERK] , and consequently STAT5 activation , sorafenib *inhibited* ERK , P38 and , dasatinib blocked SRC and STAT5 , and KNK437 decreased the stability of the JAK2 protein , reducing its expression . Negative_regulation EPHB2 TACSTD2 22419550 2606581 Enforced expression of in the lung CL line H1299 *reduced* AKT as well as [ERK] activation and suppressed cell proliferation and colony formation . Negative_regulation EPHB2 TAGLN 19796641 2153752 *inhibited* the activation of IGF-1Rbeta/Akt and [Erk] , consequently suppressing cell proliferation . Negative_regulation EPHB2 TAT 11327725 807657 Cysteine-rich and basic peptides *inhibited* VEGF induced [ERK] activation and mitogenesis in endothelial cells , and inhibited angiogenesis in vitro at concentrations similar to those which inhibited VEGF receptor binding . Negative_regulation EPHB2 TAT 12193740 981550 or PD98059 , a pharmacological mitogen activated [protein/ERK] kinase *inhibitor* , blocked both focal surface clustering of Mac-1 and the change to active conformational structure of this integrin assessed by the mAb CBRM1/5 , which binds the activation epitope . Negative_regulation EPHB2 TAT 12646200 1069937 , either membrane bound or intracellular , but not native catalase , *inhibited* serum induced Elk phosphorylation and anisomycin- and/or MG-132 induced [ERK] phosphorylation , suggesting the involvement of H ( 2 ) O ( 2 ) . Negative_regulation EPHB2 TAT 15574735 1344632 This was demonstrated by the findings that the synergistic phosphorylation of [ERK] induced by coactivation of NMDA receptors and mGluR5 was *blocked* by either a peptide that disrupts NMDA receptor/PSD-95 binding or small interfering RNAs that selectively reduce cellular levels of Homer1b/c . Negative_regulation EPHB2 TAT 16436505 1540492 Here , we report that ligation on human endothelial cells *results* in the activation of the small GTPases Ras and Rac and the mitogen activated protein kinase [ERK] , specifically through its RGD region . Negative_regulation EPHB2 TBCA 24140231 2875130 Agonist induced thromboxane A2 ( TxA2 ) generation and [ERK] phosphorylation were significantly *inhibited* by . Negative_regulation EPHB2 TDGF1P3 23359218 2738829 Deletion of the CD11b cytoplasmic tail reverses the *mediated* decrease in [ERK] and p38 activation during opsonized Schu-S4 infection . Negative_regulation EPHB2 TERF2 10476970 642767 This decrease in GTP bound *activates* [ERK/MAPK] . Negative_regulation EPHB2 TERF2 11228165 788452 Furthermore , overexpression of *enhanced* p38 activity but not [ERK] or JNK activity . Negative_regulation EPHB2 TERF2 11340161 812414 In NIH 3T3 cells , is *required* not only for cAMP 's inhibition of [ERK] activation but for inhibition of cell proliferation and mitogenesis as well . Negative_regulation EPHB2 TERF2 11479306 860610 Moreover , inhibition of by a Rap1 GTPase activating protein-1 also *resulted* in a decrease in [ERK] and Akt phosphorylation , which was not further decreased by cAMP , suggesting that cAMP inhibits ERK and Akt by inhibiting Rap1 . Negative_regulation EPHB2 TERF2 11479306 860666 The *role* of in [ERK] and Akt activity was further demonstrated by our observation that an active form of Epac , which activated Rap1 in the absence of cAMP , increased ERK and Akt phosphorylation . Negative_regulation EPHB2 TERF2 16507992 1529658 We confirm that the PKA independent activation of by Epac1 activates a perinuclear pool of Rap1 and that this does not *result* in [ERK] activation . Negative_regulation EPHB2 TERF2IP 10476970 642769 This decrease in GTP bound *activates* [ERK/MAPK] . Negative_regulation EPHB2 TERF2IP 11228165 788454 Furthermore , overexpression of *enhanced* p38 activity but not [ERK] or JNK activity . Negative_regulation EPHB2 TERF2IP 11340161 812416 In NIH 3T3 cells , is *required* not only for cAMP 's inhibition of [ERK] activation but for inhibition of cell proliferation and mitogenesis as well . Negative_regulation EPHB2 TERF2IP 11479306 860612 Moreover , inhibition of by a Rap1 GTPase activating protein-1 also *resulted* in a decrease in [ERK] and Akt phosphorylation , which was not further decreased by cAMP , suggesting that cAMP inhibits ERK and Akt by inhibiting Rap1 . Negative_regulation EPHB2 TERF2IP 11479306 860668 The *role* of in [ERK] and Akt activity was further demonstrated by our observation that an active form of Epac , which activated Rap1 in the absence of cAMP , increased ERK and Akt phosphorylation . Negative_regulation EPHB2 TERF2IP 16507992 1529661 We confirm that the PKA independent activation of by Epac1 activates a perinuclear pool of Rap1 and that this does not *result* in [ERK] activation . Negative_regulation EPHB2 TERT 12223143 987665 HRT , VCR , and Vp16 could inhibit cell proliferation ( 0.28 % 0.08 % , 0.25 % 0.16 % , 0.24 % 0.11 % ) , induce apoptosis ( 21.12 % , 28.83 % , 12.30 % ) , *inhibit* activity , and down-regulate the protein expression of phosphorylated [ERK] . Negative_regulation EPHB2 TERT 12674761 1030441 The results showed that HRT , VCR and Vp16 could inhibit cell proliferation , induce apoptosis , *inhibit* activity and down-regulate the protein expression of phosphorylated [ERK] . Negative_regulation EPHB2 TET1 22001142 2507706 At non-toxic concentrations , *inhibited* expression of phosphorylated [ERK] as well as phosphorylated IKK , enhanced degradation of I?Ba and reduced the DNA binding activity of NF-?B in IL-1ß primed PRMCs , suggesting an inhibitory effect on ERK/NF-?B signaling . Negative_regulation EPHB2 TET1 22001142 2507724 *down-regulated* [ERK/NF-?B] signaling and inhibited the expression of inflammatory mediators NO and MMP-9 . Negative_regulation EPHB2 TET2 22001142 2507704 At non-toxic concentrations , *inhibited* expression of phosphorylated [ERK] as well as phosphorylated IKK , enhanced degradation of I?Ba and reduced the DNA binding activity of NF-?B in IL-1ß primed PRMCs , suggesting an inhibitory effect on ERK/NF-?B signaling . Negative_regulation EPHB2 TET2 22001142 2507722 *down-regulated* [ERK/NF-?B] signaling and inhibited the expression of inflammatory mediators NO and MMP-9 . Negative_regulation EPHB2 TET3 22001142 2507705 At non-toxic concentrations , *inhibited* expression of phosphorylated [ERK] as well as phosphorylated IKK , enhanced degradation of I?Ba and reduced the DNA binding activity of NF-?B in IL-1ß primed PRMCs , suggesting an inhibitory effect on ERK/NF-?B signaling . Negative_regulation EPHB2 TET3 22001142 2507723 *down-regulated* [ERK/NF-?B] signaling and inhibited the expression of inflammatory mediators NO and MMP-9 . Negative_regulation EPHB2 TGFB1 12376555 996888 only partially *inhibited* EGF induced [Erk] phosphorylation . Negative_regulation EPHB2 TGFB1 18082740 1971427 , rosiglitazone ( PPARgamma agonist ) , and PD98059 ( [ERK] *inhibitor* ) were added to endometrial stromal cell culture according to experimental purposes . Negative_regulation EPHB2 TGM5 20441566 2274839 We also show that Gq plus Gi- or Gi plus Gz-mediated platelet aggregation , [ERK] phosphorylation and thromboxane A2 generation in human platelets was *inhibited* by , a PI3Kbeta-selective inhibitor , but not by PIK75 ( a PI3Kalpha inhibitor ) , AS252424 ( a PI3Kgamma inhibitor ) or IC87114 ( a PI3Kdelta inhibitor ) . Negative_regulation EPHB2 THBS1 21453480 2417311 Inhibiting activity *reduced* the elevated activation of [MEK/ERK] and expression of key fibrogenic proteins . Negative_regulation EPHB2 THBS1 21453480 2417319 also *blocked* platelet derived growth factor ( PDGF ) -induced contractile activity and [MEK/ERK] activation . Negative_regulation EPHB2 TIMP1 21600177 2435826 Western blot was used to detect the protein levels of MMP9 , prozymogen MMP9 ( pro-MMP9 ) , tissue *inhibitors* of metalloproteinases 1 ( ) , phosphorylated EGFR ( p-EGFR ) and phosphorylated external-signal regulated kinase ( [p-ERK] ) . Negative_regulation EPHB2 TLN1 21044336 2349259 suppresses growth and *induces* apoptosis of pancreatic carcinoma cells through inhibition of [Ras-ERK] MAPK signaling . Negative_regulation EPHB2 TLR1 20802527 2375234 Together , these findings suggest that the new cancer associated ligand , PAUF , may activate TLR mediated [ERK] signaling to produce the protumorigenic cytokines , but *inhibits* mediated NF-?B signaling , thereby facilitating tumor growth and escape from innate immune surveillance . Negative_regulation EPHB2 TLR10 20802527 2375242 Together , these findings suggest that the new cancer associated ligand , PAUF , may activate TLR mediated [ERK] signaling to produce the protumorigenic cytokines , but *inhibits* mediated NF-?B signaling , thereby facilitating tumor growth and escape from innate immune surveillance . Negative_regulation EPHB2 TLR2 17312106 1699607 TLR4- and also strongly *inhibited* LPS induced activation of [ERK] . Negative_regulation EPHB2 TLR2 17312106 1699609 Only significantly *inhibited* [ERK] activation induced by P3C , which acts via TLR2/1 heterodimers . Negative_regulation EPHB2 TLR2 20802527 2375235 Together , these findings suggest that the new cancer associated ligand , PAUF , may activate TLR mediated [ERK] signaling to produce the protumorigenic cytokines , but *inhibits* mediated NF-?B signaling , thereby facilitating tumor growth and escape from innate immune surveillance . Negative_regulation EPHB2 TLR3 20802527 2375236 Together , these findings suggest that the new cancer associated ligand , PAUF , may activate TLR mediated [ERK] signaling to produce the protumorigenic cytokines , but *inhibits* mediated NF-?B signaling , thereby facilitating tumor growth and escape from innate immune surveillance . Negative_regulation EPHB2 TLR4 17312106 1699608 and TLR2-BBPs also strongly *inhibited* LPS induced activation of [ERK] . Negative_regulation EPHB2 TLR4 20802527 2375237 Together , these findings suggest that the new cancer associated ligand , PAUF , may activate TLR mediated [ERK] signaling to produce the protumorigenic cytokines , but *inhibits* mediated NF-?B signaling , thereby facilitating tumor growth and escape from innate immune surveillance . Negative_regulation EPHB2 TLR4 22743248 2644396 Our flow cytometry and Western blot data showed that paclitaxel activated signaling and that IS treatment could effectively *inhibit* this paclitaxel induced activation of [TLR4-MyD88-ERK] signaling . Negative_regulation EPHB2 TLR4 22940633 2672611 Here , we demonstrate that attenuated extracellular-signal regulated kinase ( [ERK] ) 1 and 2 signaling in *response* to activation results in failure to induce IL-10 expression in monocytes from CRMO patients . Negative_regulation EPHB2 TLR5 20802527 2375238 Together , these findings suggest that the new cancer associated ligand , PAUF , may activate TLR mediated [ERK] signaling to produce the protumorigenic cytokines , but *inhibits* mediated NF-?B signaling , thereby facilitating tumor growth and escape from innate immune surveillance . Negative_regulation EPHB2 TLR6 20802527 2375243 Together , these findings suggest that the new cancer associated ligand , PAUF , may activate TLR mediated [ERK] signaling to produce the protumorigenic cytokines , but *inhibits* mediated NF-?B signaling , thereby facilitating tumor growth and escape from innate immune surveillance . Negative_regulation EPHB2 TLR7 20802527 2375239 Together , these findings suggest that the new cancer associated ligand , PAUF , may activate TLR mediated [ERK] signaling to produce the protumorigenic cytokines , but *inhibits* mediated NF-?B signaling , thereby facilitating tumor growth and escape from innate immune surveillance . Negative_regulation EPHB2 TLR8 20802527 2375240 Together , these findings suggest that the new cancer associated ligand , PAUF , may activate TLR mediated [ERK] signaling to produce the protumorigenic cytokines , but *inhibits* mediated NF-?B signaling , thereby facilitating tumor growth and escape from innate immune surveillance . Negative_regulation EPHB2 TLR9 16402377 1513165 Since both RANKL-RANK and interactions *result* in NF-kappaB activation , p38 and [ERK] phosphorylation , and TNF-alpha synthesis ( all implicated in osteoclastogenesis ) , we hypothesized that CpG-ODN ( but not RANKL ) in addition induces the synthesis of an anti-osteoclastogenic factor . Negative_regulation EPHB2 TLR9 20802527 2375241 Together , these findings suggest that the new cancer associated ligand , PAUF , may activate TLR mediated [ERK] signaling to produce the protumorigenic cytokines , but *inhibits* mediated NF-?B signaling , thereby facilitating tumor growth and escape from innate immune surveillance . Negative_regulation EPHB2 TMED7 23341544 2747455 Reduced ( 18 ) F-FLT PET reflected a modest , yet significant , reduction of Ki67 immunoreactivity , *inhibition* of p-MEK and [p-ERK] , and elevated tumor cell protein levels . Negative_regulation EPHB2 TMEFF2 23936739 2826991 Using prostate cell lines , here we examine the *role* of in [ERK] and Akt activation , two pathways implicated in prostate cancer progression and that have been shown to cross talk in several cancers . Negative_regulation EPHB2 TMEM115 17988652 1850939 specifically *inhibited* fMLP induced intracellular calcium mobilization and [ERK] ( p42/p44 ) , Akt and p38 phosphorylation . Negative_regulation EPHB2 TNF 14597634 1187475 In vitro kinase assays as well as immunoblot analysis with antibodies specific for activated MAPKs indicated that H ( 2 ) O ( 2 ) produced in *response* to potentiates the activation of JNK and p38 induced by this cytokine but inhibits that of [ERK] . Negative_regulation EPHB2 TNF 16207331 1464312 In vivo , overexpression of *induced* activation of p38MAPKalpha and [ERK] in the synovial membrane , whereas activation of JNK was less pronounced and rarely observed on immunohistochemical analysis . Negative_regulation EPHB2 TNF 19950288 2172391 In addition , cortisol increased the adhesion of SFs to fibronectin and inhibited [ERK] signaling upon integrin activation or upon *stimulation* with . Negative_regulation EPHB2 TNF 20691248 2311983 This study aims to elucidate the beneficial *role* of and HSP-70 in the regulation of apoptotic proteins and [ERK] signaling in hypoxic injury . Negative_regulation EPHB2 TNF 21042558 2344364 Genistein represses the release of and significantly *inhibits* [ERK] and P38 phosphorylation in activated microglial cells by acting as a tyrosine kinase inhibitor . Negative_regulation EPHB2 TNF 23285207 2711792 Ber or/and Y all *inhibited* LPS stimulated I?Ba , JNK and [ERK] phosphorylation , NF-?B activation as well as production . Negative_regulation EPHB2 TNF 9368689 463886 [ERK] activity was *inhibited* by both cAMP and . Negative_regulation EPHB2 TNFRSF11A 16402377 1513163 Since both and CpG-ODN-TLR9 interactions *result* in NF-kappaB activation , p38 and [ERK] phosphorylation , and TNF-alpha synthesis ( all implicated in osteoclastogenesis ) , we hypothesized that CpG-ODN ( but not RANKL ) in addition induces the synthesis of an anti-osteoclastogenic factor . Negative_regulation EPHB2 TNFSF11 16402377 1513164 Since both and CpG-ODN-TLR9 interactions *result* in NF-kappaB activation , p38 and [ERK] phosphorylation , and TNF-alpha synthesis ( all implicated in osteoclastogenesis ) , we hypothesized that CpG-ODN ( but not RANKL ) in addition induces the synthesis of an anti-osteoclastogenic factor . Negative_regulation EPHB2 TNFSF11 19756392 2183380 However , we demonstrate that silibinin can block the activation of NF-?B , c-Jun N-terminal kinase (JNK) , p38 mitogen activated protein (MAP) kinase , and extracellular signal regulated kinase ( [ERK] ) in osteoclast precursors in *response* to . Negative_regulation EPHB2 TNFSF14 19939453 2198741 in combination with IFN-gamma *resulted* in increased activation of p38 MAPK , [ERK] and IkappaB-alpha compared with TNFSF14 or IFN-gamma alone . Negative_regulation EPHB2 TP53 12048219 968720 Ectopic expression of PKCalpha or -zeta did not affect p38 kinase or [ERK] but *inhibited* the accumulation and caspase-3 activation that are required for NO-induced apoptosis of chondrocytes . Negative_regulation EPHB2 TP53 15078887 1257707 Repressing p53 with pifithrin-alpha or small interfering RNA increased ERK phosphorylation by H ( 2 ) O ( 2 ) , indicating that *dependent* suppression of [ERK] activity may contribute to the bi-stable single cell responses observed . Negative_regulation EPHB2 TP53 15880691 1432984 Mutation or suppression of in MDA-MB231 and MCF7-E6 cells , respectively , *resulted* in a strong [ERK] phosphorylation in the presence of metals . Negative_regulation EPHB2 TP53 17102589 1661066 Loss of IGFBP-2 inhibits the ability of to *inhibit* the activation of extracellular signal regulated kinase ( [ERK] ) 1 by IGF-I . Negative_regulation EPHB2 TP53 20664969 2298214 Immunoblot analysis demonstrated that oridonin treatment increased expression levels of p-JNK , p-p38 , and p21 , elevated the level of cyclin B1/p-Cdc2 ( Tyr15 ) complex , and *inhibited* the expression of [p-ERK] . Negative_regulation EPHB2 TP53 21513518 2439416 IMOS is a potential anti-HCC candidate through *inhibition* of [ERK] and JNK signaling independent of and worth studying further in patients with HCC , especially at advanced stages . Negative_regulation EPHB2 TP53 23814485 2808252 To address this , we evaluated the effects of p53 on the extracellular signal regulated kinase ( ERK ) activation and found that could *suppress* [ERK] activation through de novo synthesis . Negative_regulation EPHB2 TRH 18824214 1987698 Stimulation with continuous in perifused cells *resulted* in a similar level of [ERK] phosphorylation . Negative_regulation EPHB2 TSC2 15178807 1280494 TPA induced ERK phosphorylation was prolonged in ERC-18 cells compared to NRK-52E cells and expression of in ERC-18 cells did not *inhibit* prolonged [ERK] activation . Negative_regulation EPHB2 TSC22D3 16216878 1483501 In Xenopus oocytes with activated ERK , heterologous expression consistently *inhibited* [phospho-ERK] expression and markedly stimulated ENaC mediated Na+ current , in a manner similar to that of U0126 ( a pharmacologic inhibitor of ERK signaling ) . Negative_regulation EPHB2 TSC22D3 17956870 1830809 and GILZ3 , and to a lesser extent GILZ2 , *inhibited* [ERK] phosphorylation . Negative_regulation EPHB2 TSC22D3 17956870 1830810 Furthermore , *inhibition* of [ERK] appears to play an essential role in stimulation of cell surface ENaC but not in inhibition of proliferation . Negative_regulation EPHB2 TSC22D3 19553536 2104079 GC-induced GILZ expression and GC inhibition of NF-kappaB activation were restored by expression of ANXA1 in ANXA1 ( -/- ) cells , and overexpression in ANXA1 ( -/- ) macrophages *reduced* [ERK] MAPK phosphorylation and restored sensitivity of cytokine expression and NF-kappaB activation to GC . Negative_regulation EPHB2 TSC22D3 22396737 2566834 Further studies show that these antagonistic actions occur via mechanisms involving *inhibition* of TNF-a induced [ERK] MAP kinase activation and protein degradation . Negative_regulation EPHB2 TSC22D3 23729444 2801849 overexpression also *inhibited* TNF induced activation of p38 , [ERK] , and JNK MAPKs , as well as increased expression of the MAPK inhibitory phosphatase , MKP-1 . Negative_regulation EPHB2 TYR 15170389 1280324 Expression of the Gab2 -- > Phe ( Y614F ) mutant , defective in SHP-2 association , *prevents* [ERK] ( extracellular-signal regulated kinase ) activation and expression of a luciferase reporter plasmid driven by the c-fos SRE ( serum response element ) , indicating that interaction of SHP-2 with Gab2 is required for ERK activation in response to IL-2 . Negative_regulation EPHB2 UCHL1 19945429 2198958 In rat adult VSMCs , adenoviral over-expression of *inhibited* TNFalpha induced activation of [ERK] and DNA synthesis . Negative_regulation EPHB2 UCN 17027144 1674313 Bisindolylmaleimide partially inhibited the *mediated* decrease in [ERK] phosphorylation in A7r5 cells , suggesting that the protein kinase C pathway is partially involved in CRF2 receptor signal transduction . Negative_regulation EPHB2 UMOD 19071107 2024134 Furthermore , *inhibited* the increased phosphorylation of [ERK] and CREB in nucleus accumbens and hippocampus of rats . Negative_regulation EPHB2 UMOD 24269936 2898327 Therefore , the current study aims to examine the *roles* of in the development and expression of METH induced locomotor sensitization as well as the accompanying [extracellular regulated kinase (ERK)] activation in the nucleus accumbens (NAc) , caudate putamen (CPu) and prefrontal cortex (PFc) in mice . Negative_regulation EPHB2 UNC119 19144852 2026175 The *dependent* inhibition of [ERK] activity provides a potential mechanism for synapse-specific control of active zone protein composition and release probability . Negative_regulation EPHB2 UNC119 23535298 2772542 We show that the midbody localization of UNC119a is dependent on Rab11 , and that knocking down *inhibits* the Rab11 dependent phosphorylation and midbody localization of [ERK] and cytokinesis . Negative_regulation EPHB2 UNC50 19144852 2026176 The dependent *inhibition* of [ERK] activity provides a potential mechanism for synapse-specific control of active zone protein composition and release probability . Negative_regulation EPHB2 UNC79 19144852 2026177 The *dependent* inhibition of [ERK] activity provides a potential mechanism for synapse-specific control of active zone protein composition and release probability . Negative_regulation EPHB2 UNC80 19144852 2026178 The dependent *inhibition* of [ERK] activity provides a potential mechanism for synapse-specific control of active zone protein composition and release probability . Negative_regulation EPHB2 UTP15 10585878 571576 However , PP2 inhibited [ERK] activation in *response* to NE and , but not in response to EGF or NGF . Negative_regulation EPHB2 UTP18 10585878 571574 However , PP2 inhibited [ERK] activation in *response* to NE and , but not in response to EGF or NGF . Negative_regulation EPHB2 UTP20 10585878 571572 However , PP2 inhibited [ERK] activation in *response* to NE and , but not in response to EGF or NGF . Negative_regulation EPHB2 UTP23 10585878 571577 However , PP2 inhibited [ERK] activation in *response* to NE and , but not in response to EGF or NGF . Negative_regulation EPHB2 UTP3 10585878 571575 However , PP2 inhibited [ERK] activation in *response* to NE and , but not in response to EGF or NGF . Negative_regulation EPHB2 UTP6 10585878 571573 However , PP2 inhibited [ERK] activation in *response* to NE and , but not in response to EGF or NGF . Negative_regulation EPHB2 VAV1 10898494 712072 Conversely , however , dominant negative did not *inhibit* NFAT and [ERK] activation or CD69 expression induced by an active Ras mutant . Negative_regulation EPHB2 VEGFA 11171046 783705 Wortmannin partially inhibited stimulation of PGI ( 2 ) production , but did not *inhibit* VEGF induced [ERK] activity . Negative_regulation EPHB2 VEGFA 15541367 1336921 stimulation did not induce ERK phosphorylation in human PKCdelta-knockdown HEK293T cells , but co-expression of rat PKCdelta-GFP *recovered* the [ERK] phosphorylation . Negative_regulation EPHB2 VEGFA 16101130 1444139 R115777 +/- paclitaxel inhibited HDJ-2 farnesylation , up-regulated RhoB , transiently lowered ( P ) [ERK/ERK] and ( P ) Akt/Akt , reduced Raf-1 and MEK and *inhibited* secretion of and MMP-1 . Negative_regulation EPHB2 VEGFA 16436494 1527836 In addition , a mutant , which binds only KDR , induced extracellular signal regulated kinase ( ERK ) activation , and *inhibition* of [ERK] completely blocked endothelial cell proliferation under this condition , suggesting a role of the KDR-ERK1/2 pathway on endothelial cell proliferation . Negative_regulation EPHB2 VEGFA 16672338 1558638 By contrast , dependent ganglion cell suppression does not *require* [MEK-ERK] activation , but instead relies on VEGF stimulated HES1 activity , which is independent of NOTCH signaling . Negative_regulation EPHB2 VEGFA 16724983 1565613 Furthermore , H ( 2 ) O ( 2 ) -induced phosphorylation of [ERK] and JNK was also *reduced* by ( 100 ng/mL ) . Negative_regulation EPHB2 VEGFA 21781996 2500350 Interestingly , and PD98059 ( an [ERK] kinase *inhibitor* ) play a synergistic role in protecting neurons from MPP ( + ) -induced toxicity . Negative_regulation EPHB2 VEGFA 21801813 2505339 up-regulates the activity of ERK ( extracellular signal regulated kinase ) in cultured cortical neurons and U0126 ( a mitogen activated protein kinase kinase ( MEK ) inhibitor ) *suppressed* VEGF induced activity of [ERK] . Negative_regulation EPHB2 VEGFA 22265793 2559737 In addition , vascular endothelial growth factor ( VEGF ) protein was strongly detected in conditioned medium derived from Dab2 overexpressing SW480 cells , and [Erk] phosphorylation enhanced by Dab2 ( + ) CM was *restored* by inhibition . Negative_regulation EPHB2 VEGFA 23570600 2767998 PGE1 time-dependently *induced* both phosphorylation of [ERK] and p38 in HUVEC , whereas ERK inhibitor , PD98059 , or p38 inhibitor , SB203580 , blocked PGE1 induced expression of HUVEC , resulting in dramatically suppression of HUVEC proliferation and migration compared with PGE1 treatment alone ( 60 % and 55 % by PD98059 , 62 % and 51 % by SB203580 , respectively ) ; Negative_regulation EPHB2 VEGFA 23869238 2817633 BBR also downregulated HIF-1a and expression and *inhibited* Akt and [ERK] phosphorylation . Negative_regulation EPHB2 VEGFA 24297449 2894595 Here , we report that SAHA was able to inhibit the proliferation of the LCC cell line NCI-H460 in a dose- and time dependent manner , induced cell apoptosis and G2/M cell cycle arrest , decreased AKT and [ERK] phosphorylation , *inhibited* the expression of pro-angiogenic factors ( , HIF-1a ) in vitro , and suppressed tumor progression in an NCI-H460 cell nude mouse xenograft model in vivo . Negative_regulation EPHB2 VIP 18174366 1883373 interaction *results* in cAMP independent [PI-3K/ERK] activation with downstream integrin up-regulation . Negative_regulation EPHB2 VRK2 20679487 2317334 The molecular mechanism lies between MAPK/ERK kinase (MEK) and ERK , since MEK remains phosphorylated while [ERK] phosphorylation is *blocked* by . Negative_regulation EPHB2 WARS2 15579907 1361380 Binding of *inhibited* VEGF induced [ERK] activation and EC migration . Negative_regulation EPHB2 XRCC5 10476970 642768 This decrease in GTP bound *activates* [ERK/MAPK] . Negative_regulation EPHB2 XRCC5 11228165 788453 Furthermore , overexpression of *enhanced* p38 activity but not [ERK] or JNK activity . Negative_regulation EPHB2 XRCC5 11340161 812415 In NIH 3T3 cells , is *required* not only for cAMP 's inhibition of [ERK] activation but for inhibition of cell proliferation and mitogenesis as well . Negative_regulation EPHB2 XRCC5 11479306 860611 Moreover , inhibition of by a Rap1 GTPase activating protein-1 also *resulted* in a decrease in [ERK] and Akt phosphorylation , which was not further decreased by cAMP , suggesting that cAMP inhibits ERK and Akt by inhibiting Rap1 . Negative_regulation EPHB2 XRCC5 11479306 860667 The *role* of in [ERK] and Akt activity was further demonstrated by our observation that an active form of Epac , which activated Rap1 in the absence of cAMP , increased ERK and Akt phosphorylation . Negative_regulation EPHB2 XRCC5 16507992 1529659 We confirm that the PKA independent activation of by Epac1 activates a perinuclear pool of Rap1 and that this does not *result* in [ERK] activation . Negative_regulation EPHB2 XRCC6 10476970 642771 This decrease in GTP bound *activates* [ERK/MAPK] . Negative_regulation EPHB2 XRCC6 11228165 788456 Furthermore , overexpression of *enhanced* p38 activity but not [ERK] or JNK activity . Negative_regulation EPHB2 XRCC6 11340161 812418 In NIH 3T3 cells , is *required* not only for cAMP 's inhibition of [ERK] activation but for inhibition of cell proliferation and mitogenesis as well . Negative_regulation EPHB2 XRCC6 11479306 860614 Moreover , inhibition of by a Rap1 GTPase activating protein-1 also *resulted* in a decrease in [ERK] and Akt phosphorylation , which was not further decreased by cAMP , suggesting that cAMP inhibits ERK and Akt by inhibiting Rap1 . Negative_regulation EPHB2 XRCC6 11479306 860670 The *role* of in [ERK] and Akt activity was further demonstrated by our observation that an active form of Epac , which activated Rap1 in the absence of cAMP , increased ERK and Akt phosphorylation . Negative_regulation EPHB2 XRCC6 16507992 1529663 We confirm that the PKA independent activation of by Epac1 activates a perinuclear pool of Rap1 and that this does not *result* in [ERK] activation . Negative_regulation EPHB2 YWHAB 20810616 2341717 We found that nanomolar concentrations of Sorafenib reduced the basal activity of [ERK] , *inhibited* cAMP dependent activation of and MEK/ERK signaling , and caused a concentration dependent inhibition of cell proliferation induced by cAMP , epidermal growth factor , or the combination of the two agonists . Negative_regulation EPHB2 ZFP36 21593445 2470244 Constitutive [ERK] activity *induces* downregulation of , a major protein controlling interleukin8/CXCL8 mRNA stability in melanoma cells . Negative_regulation EPHB2 ZFPM2 23788640 2824202 In addition , down-regulation of by miR-200b/c could *activate* not only Akt but also [ERK] , which was also through PI3K activation . Negative_regulation EPHB2 ZNF382 12720544 1106470 Infection of cells with adenoviruses encoding dominant negative PKCdelta or epsilon inhibited the activation of extracellular-signal regulated kinase ( [ERK] ) by PE , and also *inhibited* the activation and/or phosphorylation of and 2 . Negative_regulation EPO IL1B 1712553 161232 A dose dependent decrease of up to 60 % in [Epo] production was *induced* by , interleukin-1 alpha , and tumor necrosis factor-alpha ( in that order of potency ) . Negative_regulation EPO NT5E 16468051 1561418 The aim of the present study was to evaluate the *role* of in [erythropoietin (EPO)] production and to determine its influence on basal kidney perfusion using a CD73 knockout mutant recently generated by us . Negative_regulation EPO TNF 10029160 591531 p55 receptor ( TNF-RI ) *mediates* the in vitro inhibition of hepatic [erythropoietin] production . Negative_regulation EPO TNF 1712553 161228 Interleukin-1 and *inhibit* [erythropoietin] production in vitro . Negative_regulation EPO TNF 1712553 161230 A dose dependent decrease of up to 60 % in [Epo] production was *induced* by interleukin-1 beta , interleukin-1 alpha , and ( in that order of potency ) . Negative_regulation EPO TNF 23659067 2784788 In most CHD patients elevated levels of *inhibited* hepatic synthesis of [EPO] . Negative_regulation EPO TNF 7528138 280925 Hypoxia induced [erythropoietin (Epo)] production in vitro is *suppressed* by interleukin 1 beta (IL-1 beta) , and phorbol esters . Negative_regulation EPRS DAPK1 18995835 1990133 Inhibition of and ZIPK facilitates cell restoration to the basal state and *allows* renewed induction of [GAIT] target transcripts by repeated stimulation . Negative_regulation EPX IL1B 12958195 1138269 However , 15 U/ml , 220 U/ml TNF-alpha , or 10 ( -3 ) M L-NMMA *inhibited* [Epo] protein production and promoter activity , respectively . Negative_regulation EPX IL1B 9321887 456328 In addition , LPS and ( 1 microgram/kg ) *inhibited* the increase in EPO mRNA and plasma [EPO] levels when administered to rats before hypoxia exposure ( 8 % O2 in the inspiratory gas ) . Negative_regulation EPX TNF 10029160 591533 The present study was carried out to find out as to whether the 55 kD ( TNF-RI ) or the 75 kD ( TNF-RII ) receptor is responsible for the *induced* inhibition of hepatic [Epo] synthesis . Negative_regulation EPX TNF 11225250 763969 and IFN-gamma could specifically *inhibit* cobalt induced [Epo] production in HepG2 cells , and suppressed normal bone marrow BFU-E and CFU-E growth in a dose dependent manner . Negative_regulation EPX TNF 12958195 1138268 However , 15 U/ml IL-1beta , 220 U/ml , or 10 ( -3 ) M L-NMMA *inhibited* [Epo] protein production and promoter activity , respectively . Negative_regulation EPX TNF 18399174 1840257 might *inhibit* [EPO] production and erythropoiesis , while IFN-gamma maybe directly inhibit erythropoiesis and be independent of EPO response inadequacy . Negative_regulation ERBB2 ADAMTS1 16314835 1546922 Overexpression of in these cells *promoted* tumor angiogenesis and invasion , shedding of the transmembrane precursors of heparin binding epidermal growth factor (EGF) and amphiregulin (AR) , and activation of the EGF receptor and [ErbB-2] , while overexpression of ADAMTS-1E/Q inhibited these events . Negative_regulation ERBB2 FAS 15780499 1385304 On the other hand , chemical inhibitors as well as RNA interference *mediated* silencing of FAS gene repress [Her-2/neu] gene expression at the transcriptional level . Negative_regulation ERBB2 MMP28 19457660 2090862 Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent selectivity and [HER-2] sheddase *inhibition* . Negative_regulation ERBB2 MMP7 19457660 2090877 Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent selectivity and [HER-2] sheddase *inhibition* . Negative_regulation ERBB2 TNF 18701712 1950526 also activated ErbB2 , and loss of [ErbB2] expression *increased* TNF induced apoptosis . Negative_regulation ERBB2 TNF 8105469 231406 In our study we show that the *mediated* down-regulation of [ERBB2] in pancreatic tumor cells is accompanied by an increase in growth inhibition at low doses of TNF . Negative_regulation ERBB4 GPR115 21898395 2554700 These results suggest that the down-regulation of [ErbB4] expression is *induced* by stimulation . Negative_regulation ERBB4 GPR132 21898395 2554689 These results suggest that the down-regulation of [ErbB4] expression is *induced* by stimulation . Negative_regulation ERBB4 GPR87 21898395 2554769 These results suggest that the down-regulation of [ErbB4] expression is *induced* by stimulation . Negative_regulation ERCC6L TNF 22025632 2508070 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation ERF MAP2K6 20021813 2175441 ST [induced-p-ERK1/2] expression was partially *blocked* by and IGF-1R inhibitors . Negative_regulation ERG TNF 10574717 569189 The Ets family member [Erg] was found to be constitutively expressed in HUVEC , and *down-regulated* Erg protein levels . Negative_regulation ERG TNF 11719371 883681 It has recently been shown that the transcription factor [Erg] , an Ets family member , drives constitutive expression of the intercellular adhesion molecule 2 ( ICAM-2 ) in human umbilical vein endothelial cells ( HUVECs ) and that its expression is *down-regulated* by the pleiotropic cytokine . Negative_regulation ERVK-6 CST6 10675539 667867 A cysteine [proteinase] *inhibitor* ( ) from chestnut ( Castanea sativa ) seeds , designated CsC , has been previously characterized . Negative_regulation ERVK-6 CST6 10848919 701086 To test the effects of several [proteinase] *inhibitors* , mainly a chestnut ( CsC ) , on the enzymatic activity of Der p 1 and Der f 1 , as well as to study the potential acaricide properties of the inhibitors . Negative_regulation ERVK-6 CST6 12450152 1018327 Molecular cloning and functional expression of cDNA encoding a cysteine [proteinase] *inhibitor* , , from Job 's tears ( Coix lacryma-jobi L. var. Ma-yuen Stapf ) . Negative_regulation ERVK-6 CST6 12450152 1018337 A cDNA clone for a cysteine [proteinase] *inhibitor* , , was isolated from the library . Negative_regulation ERVK-6 CST6 1390644 198737 The Cys-71-Cys-81 disulfide bond of the cysteine [proteinase] *inhibitor* , chicken , was specifically reduced by thioredoxin or low concentrations of dithiothreitol . Negative_regulation ERVK-6 CST6 1425699 202309 A full-length cDNA clone for a cysteine [proteinase] *inhibitor* ( ) was isolated from a lambda gt10 cDNA library of immature corn kernels by screening with a mixture of cDNA inserts for oryzacystatins I and II . Negative_regulation ERVK-6 CST6 14871367 1208164 Genetically modified ( GM ) potatoes expressing a cysteine [proteinase] *inhibitor* ( ) have been developed as an option for the management of plant parasitic nematodes . Negative_regulation ERVK-6 CST6 1544477 183440 Far-ultraviolet circular dichroism and tryptophan fluorescence measurements showed that the reversible unfolding of the cysteine [proteinase] *inhibitor* , chicken , by guanidinium chloride is a two-step process with transition midpoints at approximately 3.4 and approximately 5.4 M denaturant . Negative_regulation ERVK-6 CST6 16410454 1533764 The cysteine [proteinase] *inhibitor* , egg white , was biotinylated and used as an active-site directed probe for cathepsins . Negative_regulation ERVK-6 CST6 1685882 175315 The effect of adrenergic agonists and antagonists on [cysteine-proteinase] *inhibitor* ( ) in rat saliva . Negative_regulation ERVK-6 CST6 1690669 128448 Papaya [proteinase] IV ( PPIV ) is not *inhibited* by chicken , or human cystatins A or C , unlike most other proteinases of the papain superfamily . Negative_regulation ERVK-6 CST6 1697595 139549 Oryzacystatin ( oryzacystatin-I ) is a proteinaceous cysteine [proteinase] *inhibitor* ( ) in rice seeds and is the first well defined cystatin of plant origin . Negative_regulation ERVK-6 CST6 1801730 176962 A full length cDNA clone coding for the cysteine [proteinase] *inhibitor* , chicken , was used to hybridize to RNA extracted from various tissues of the hen during several well defined stages of the 25 h ovulatory cycle . Negative_regulation ERVK-6 CST6 2022776 157235 The effects of autonomic drugs on the concentration of kallikrein-like proteases and [cysteine-proteinase] *inhibitor* ( ) in rat whole saliva . Negative_regulation ERVK-6 CST6 2022776 157245 The influence of isoproterenol , phenylephrine , propranolol , and reserpine on the salivary concentration of kallikrein-like proteases and [cysteine-proteinase] *inhibitor* ( ) was investigated . Negative_regulation ERVK-6 CST6 22802712 2628673 Among the genes identified in non stressed roots only were Ser/Thr protein kinases , wound induced basic protein , ethylene-responsive family protein , metallothionein-like protein cysteine [proteinase] *inhibitor* ( ) and Putative Kunitz trypsin protease inhibitor . Negative_regulation ERVK-6 CST6 2292589 149535 Purification and complex formation analysis of a cysteine [proteinase] *inhibitor* ( ) from seeds of Wisteria floribunda . Negative_regulation ERVK-6 CST6 2292589 149545 Seeds of Wisteria floribunda contain several kinds of cysteine [proteinase] *inhibitor* ( ) . Negative_regulation ERVK-6 CST6 2338365 133802 A rapid radioimmunoassay for inducible rat submandibular gland cysteine [proteinase] *inhibitor* ( ) . Negative_regulation ERVK-6 CST6 2757396 116374 Amino acid sequence of an inducible cysteine [proteinase] *inhibitor* ( ) from submandibular glands of isoproterenol treated rats . Negative_regulation ERVK-6 CST6 3286638 92941 Oryzacystatin , a proteinaceous cysteine [proteinase] *inhibitor* ( ) in rice , is comprised of 102 residues ( Met1-Ala102 ) ( Abe , K. , Emori , Y. , Kondo , H. , Suzuki , K. , and Arai , S. ( 1987 ) J. Biol. Chem. 262 , 16793-16797 ) . Negative_regulation ERVK-6 CST6 3555467 68257 Our laboratory has been involved in the study of the role of lysosomal proteinases , namely , cathepsins B , H and L and the endogenous cysteine [proteinase] *inhibitor* , , during muscle differentiation in vitro . Negative_regulation ERVK-6 CST6 8162186 254437 It is known that the cysteine [proteinase] *inhibitor* , , has a defence function against exogenous pathogens . Negative_regulation ERVK-6 CST6 8464079 215930 The structure of the intensely sweet protein monellin , isolated from an African berry , and the structures of two thiol [proteinase] *inhibitors* , and stefin B , are found to be very similar . Negative_regulation ERVK-6 CST6 8709954 373558 A 711-bp cDNA encoding a cysteine [proteinase] *inhibitor* ( ) was isolated from a cDNA library prepared from 7-10 cm Sorghum bicolor seedlings . Negative_regulation ERVK-6 CST6 8995380 409491 Identification , cloning , and characterization of , a novel cysteine [proteinase] *inhibitor* , down-regulated in breast cancer . Negative_regulation ERVK-6 F2R 10780327 687585 Stimulation of human platelets with thrombin or agonist peptide ( TRAP/ Ser-Phe-Leu-Leu-Arg-Asn ) *resulted* in phosphorylation of the [protease activated receptor 1 (PAR1)] . Negative_regulation ERVK-6 FGFBP1 8543164 338815 These include cDNAs that encode keratins K5 and K14 which are cytoskeletal proteins normally expressed in lining epithelia , the 14-3-3 protein stratifin/HME-1 , lipocortin-II and CaN19 which are calcium binding proteins that may play a role in HKc differentiation by regulating protein kinase C , plasminogen-activator inhibitor-2 which is a [serine-proteinase] *inhibitor* , which is a HKc-specific secreted inhibitor of fibroblast growth factors , integrin alpha 3 which plays a role in the anchoring of keratinocytes to basement membrane , and YL-8 , a ras-like protein that probably mediates intracellular protein trafficking . Negative_regulation ERVK-6 FUT4 6086386 39750 The synthetic [proteinase] *inhibitor* , ( 6-amidino-2-naphthyl-4-guanidinobenzoate ) , strongly suppressed activation of Clr at 37 degrees C , causing 50 % inhibition at 0.03 mM . Negative_regulation ERVK-6 IL1B 2452086 91087 The stimulation of alpha 2-macroglobulin and cysteine [proteinase] inhibitor synthesis by interleukin-6 was *inhibited* by in a dose dependent manner . Negative_regulation ERVK-6 PLAU 12967336 1138866 Primary mouse osteoblasts expressed mRNA for ( uPA ) , tIssue type plasminogen activator ( tPA ) , the type I receptor for uPA , plasminogen activator inhibitor types I and II and the broad spectrum serine [proteinase] *inhibitor* , protease nexin I . Negative_regulation ERVK-6 TF 6194014 31231 The translation products were immunoprecipitated with specific antisera against alpha 1-acid glycoprotein , alpha 2-macroglobulin , , alpha [1-proteinase] *inhibitor* and albumin . Negative_regulation ERVK-6 TF 6198795 33729 The serum proteins supposed to be indicative of the nutritional status , albumin , prealbumin and , as well as the serum [proteinase] *inhibitors* alpha 1-protease inhibitor ( alpha 1-antichymotrypsin ( Ach ) and alpha 2-macroglobulin (alpha 2M) were measured in 14 Thai males suffering from uncomplicated falciparum malaria on the day of admission and after treatment with mefloquin on the 2nd , 28th and 63rd day . Negative_regulation ERVK-6 TFPI2 11945080 930059 factor pathway inhibitor-2 ( TFPI-2 ) , a serine [proteinase] *inhibitor* , is homologous to tissue factor pathway inhibitor (TFPI) and commonly found in peripheral blood of pregnant woman . Negative_regulation ERVK-6 TFPI2 12606321 1079514 ( TFPI-2 ) , a Kunitz-type [proteinase] *inhibitor* , might play an important role during placenta growth by regulating trophoblast invasion and differentiation . Negative_regulation ERVK-6 TFPI2 20113832 2202197 , a Kunitz-type serine [proteinase] *inhibitor* , has been identified as a putative tumor-suppressor gene from genome-wide screening for aberrant methylation , using a microarray combined with the methyltransferase inhibitor 5-aza-2'-deoxycytidine ( 5-aza-dCyd ) in various types of tumors . Negative_regulation ERVK-6 TFPI2 20530429 2271424 Recently , it has been reported that ( tissue factor pathway inhibitor-2 ) , a Kunitz-type serine [proteinase] *inhibitor* , is frequently methylated in human colorectal cancer using a gene expression array based strategy . Negative_regulation ESAM TNF 7545397 318534 Inhibition of *induced* human aortic [endothelial cell adhesion molecule] gene expression by an alkoxybenzo [ b ] thiophene-2-carboxamide . Negative_regulation ESR1 FAS 15094777 1258184 inhibition also *resulted* in a marked downregulation of E2-stimulated [ERalpha] expression , and noticeably impaired E2-induced ERalpha nuclear accumulation . Negative_regulation ESR1 KLF9 20164373 2236320 We had shown previously that the transcription factor *represses* [ESR1] expression and activity in Ishikawa endometrial glandular epithelial cells . Negative_regulation ESR1 KLF9 20164373 2236322 Loss of expression *resulted* in increased glandular [ESR1] immunoreactivity with DES , without effects on serum estradiol levels . Negative_regulation ESR1 NR2F1 20382891 2261898 Expression of in COUP-TFII ablated uterus *suppressed* aberrant [estrogen receptor-alpha] activities and rescued implantation and decidualization defects of COUP-TFII mutants , suggesting that COUP-TFI and COUP-TFII are able to functionally compensate for each other in the uterus . Negative_regulation ESR1 TNF 17967830 1931706 By contrast , the [erythrocyte sedimentation rate (ESR)] declined in *response* to antagonist therapy in GR and PR . TNF antagonist therapy did not promote change in blood leukocyte BLyS mRNA levels in either GR or PR , suggesting that the TNF antagonist associated changes in circulating BLyS protein levels reflected changes in local BLyS production in the affected joints rather than changes in systemic BLyS production . Negative_regulation ETS1 EDN2 1917960 168288 Receptor binding assay using [ 125I ] ET indicated that unlabeled ET-1 or competitively *inhibited* each binding of labeled [ETs] to melanocytes with a concentration for half-maximal inhibition ( IC50 ) of 0.7 or 0.9 nM , respectively . Negative_regulation ETS1 ID1 11507043 848051 Recently has been shown to *repress* [Ets-] and E-protein mediated transactivation of p16/Ink4a . Negative_regulation ETS2 EDN2 1917960 168290 Receptor binding assay using [ 125I ] ET indicated that unlabeled ET-1 or competitively *inhibited* each binding of labeled [ETs] to melanocytes with a concentration for half-maximal inhibition ( IC50 ) of 0.7 or 0.9 nM , respectively . Negative_regulation ETS2 ID1 11507043 848052 Recently has been shown to *repress* [Ets-] and E-protein mediated transactivation of p16/Ink4a . Negative_regulation EXOSC10 TNF 2226778 144486 Stability studies of IL-6 transcripts in fibroblasts showed that *delayed* IL-6 [mRNA decay] but not LT . Negative_regulation EXOSC2 TNF 2226778 144479 Stability studies of IL-6 transcripts in fibroblasts showed that *delayed* IL-6 [mRNA decay] but not LT . Negative_regulation EXOSC4 TNF 2226778 144481 Stability studies of IL-6 transcripts in fibroblasts showed that *delayed* IL-6 [mRNA decay] but not LT . Negative_regulation EZR PODXL 17616675 1769309 These findings suggest that leads to increased in vitro migration and invasion , increased MMP expression , and *increased* activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with [ezrin] . Negative_regulation F10 F3 3917812 45763 Anticoagulation was thereafter measured , every four hours for 48 hours , by activated partial time , thrombin time , and [coagulation factor] Xa *inhibition* assay . Negative_regulation F10 TFPI2 12362512 995107 Conversely , does not *inhibits* [factor Xa] , but it is a strong inhibitor of factor XIa , plasma kallikrein , plasmin and trypsin . Negative_regulation F10 TFPI2 8159751 254341 at high concentrations weakly *inhibited* the amidolytic activity of human [factor Xa] , but had no measurable effect on the amidolytic activity of human thrombin . Negative_regulation F11 F3 3917812 45764 Anticoagulation was thereafter measured , every four hours for 48 hours , by activated partial time , thrombin time , and [coagulation factor] Xa *inhibition* assay . Negative_regulation F11 TFPI2 8555184 347345 In addition to its ability to inhibit the amidolytic and proteolytic activities of the factor VIIa-tissue factor complex , strongly *inhibited* the amidolytic activities of human [factor XIa] , human plasma kallikrein , and human plasmin with Ki values of 15 , 25 , and 3 nM , respectively . Negative_regulation F12 F3 3917812 45765 Anticoagulation was thereafter measured , every four hours for 48 hours , by activated partial time , thrombin time , and [coagulation factor] Xa *inhibition* assay . Negative_regulation F12 PLAT 1737024 181840 An amount of PIXI which inhibited by 50 % factor XIa cleavage of the chromogenic substrate S2366 ( Pyr-Glu-Pro-Arg-pNA-2H2O ) only slightly inhibited ( 5-9 % ) [factor XIIa] , plasma kallikrein , plasmin , and activated protein C and did not *inhibit* factor Xa , thrombin , , or trypsin , suggesting specificity for factor XIa . Negative_regulation F13A1 FHL1 7059522 19927 Furthermore , *inhibited* the thrombin dependent activation of [factor XIII] in human plasma . Negative_regulation F13A1 TGM2 2879844 69553 GTP also inhibited rat liver and adult bovine aortic endothelial cell , but did not *inhibit* [Factor XIIIa] activity . Negative_regulation F13B FHL1 7059522 19928 Furthermore , *inhibited* the thrombin dependent activation of [factor XIII] in human plasma . Negative_regulation F2 F3 3917812 45766 Anticoagulation was thereafter measured , every four hours for 48 hours , by activated partial time , thrombin time , and [coagulation factor] Xa *inhibition* assay . Negative_regulation F2R ARHGEF1 16554409 1562105 Both LPA ( 1 ) and [PAR1] receptor mediated activation of PLC-epsilon was *inhibited* by coexpression of the regulator of G protein signaling (RGS) domain of , a GTPase activating protein for Galpha(12/13) but not by expression of the RGS domain of GRK2 , which inhibits Galpha ( q ) signaling . Negative_regulation F2R CPB1 9485228 488276 These results imply that prevention of the *induced* effects on the [thrombin receptor] will lessen postoperative morbidity associated with blood transfusion . Negative_regulation F2R CPB2 9485228 488277 These results imply that prevention of the *induced* effects on the [thrombin receptor] will lessen postoperative morbidity associated with blood transfusion . Negative_regulation F2R CTSG 10893407 730544 However , thrombin receptor agonist peptide ( an agonist of protease activated receptor-1 (PAR-1) ) , could not mimic the effect of thrombin , and , a [PAR-1] *inhibitor* , did not reduce the effect of thrombin . Negative_regulation F2R CTSG 11701759 878761 The effect of THR , but not that of PAR1-AP , was significantly inhibited by hirulog ( TM ) ( 60 microg/mL ) , a specific and stochiometric THR inhibitor or by ( 40 mU/mL ) , an *inhibitor* of [PAR-1] . Negative_regulation F2R F2RL1 15550483 1374891 Coexpression of with TF *enhanced* rTFPI mediated inhibition of TF-VIIa-Xa mediated [PAR1] signaling , suggesting an unexpected role of PAR2 in the inhibitory control of TF signaling . Negative_regulation F2R GPI 8360259 227769 [Thrombin receptor] activating peptides ( TRAPs ) as short as 5 amino acids *induced* significant levels of synthesis and expression of PDGF mRNA in human endothelium and produced dose dependent cellular contraction and permeability of confluent human umbilical vein and bovine pulmonary artery endothelial monolayers . Negative_regulation F2R KLF2 16514085 1549226 Mechanistically , *inhibits* [PAR-1] expression and , as a consequence , thrombin mediated nuclear factor kappaB (NF-kappaB) nuclear accumulation and DNA binding . Negative_regulation F2R KLK4 20056842 2218420 ( 1 micromol/L ) *initiated* loss of [PAR1] and PAR2 from the HT29 cell surface as well as increased intracellular calcium transients in HT29 cells . Negative_regulation F2R MMP1 21093894 2376974 Furthermore , MMP-1 and [PAR1] were both significantly *induced* by LPA ( 20 µM ) , and siRNA silencing of and PAR1 both significantly reduced LPA 's invasion promoting effect in DOV13 cells ( p < 0.05 ) . Negative_regulation F2R NFKB1 9199198 438638 This study investigates the *role* of the transcription factor in thrombin- and [thrombin receptor] activating peptide ( TRAP , SFLLRNPNDKYEPYF ) -induced mitogenesis of cultured bovine coronary artery smooth muscle cells (SMC) . Negative_regulation F2R PHB 24732013 2936182 For both the endothelial and cancel cells , *repressed* [PAR1] degradation , while knockdown of PHB led to increased PAR1 degradation , and PHB overexpression inhibited PAR1 degradation . Negative_regulation F2R PTPN11 17507984 1745063 Furthermore , induction of the hummingbird phenotype by CagA activated *requires* simultaneous inhibition of [PAR1] kinase activity by CagA . Negative_regulation F2R RELA 9199198 438639 This study investigates the *role* of the transcription factor in thrombin- and [thrombin receptor] activating peptide ( TRAP , SFLLRNPNDKYEPYF ) -induced mitogenesis of cultured bovine coronary artery smooth muscle cells (SMC) . Negative_regulation F2R RGS2 24297163 2899051 We further found that ectopic expression of R4 subfamily members , RGS3 , RGS4 , and RGS5 *reduced* activated [PAR1] wild-type signaling , whereas signaling by the PAR1 AKKAA mutant was minimally affected . Negative_regulation F2R RGS4 24297163 2899049 We further found that ectopic expression of R4 subfamily members RGS2 , RGS3 , , and RGS5 *reduced* activated [PAR1] wild-type signaling , whereas signaling by the PAR1 AKKAA mutant was minimally affected . Negative_regulation F2R RGS5 24297163 2899050 We further found that ectopic expression of R4 subfamily members RGS2 , RGS3 , RGS4 , and *reduced* activated [PAR1] wild-type signaling , whereas signaling by the PAR1 AKKAA mutant was minimally affected . Negative_regulation F2R S100A8 17507984 1745062 Association of *inhibits* [PAR1] kinase activity and prevents atypical protein kinase C ( aPKC ) -mediated PAR1 phosphorylation , which dissociates PAR1 from the membrane , collectively causing junctional and polarity defects . Negative_regulation F2R S100A8 19546211 2116761 also interacts with and *inhibits* [partitioning-defective 1 (PAR1)/MARK] kinase , which phosphorylates microtubule associated proteins to destabilize microtubules and thereby causes epithelial polarity defects . Negative_regulation F2R S100A8 19546211 2116762 In light of the notion that microtubules are not only required for polarity regulation but also essential for the formation of mitotic spindles , we hypothesized that mediated [PAR1] *inhibition* also influences mitosis . Negative_regulation F2R S100A8 19546211 2116763 Thus , *mediated* inhibition of [PAR1] , which perturbs microtubule stability and thereby causes microtubule based spindle dysfunction , is involved in the prophase/metaphase delay and subsequent spindle misorientation . Negative_regulation F2R TFAP2A 12789289 1097465 Our analysis of AP-2/Sp1 complexes within the regulatory region of the thrombin receptor demonstrates that binds the proximal 3 ' region of the promoter and *diminishes* [PAR-1] expression . Negative_regulation F2R TNF 12182841 977888 The stimulation with 100 U/ml transiently *down-regulated* the [PAR-1] mRNA expression to approximately 0.3-fold of the basal level at 30 min , but it rebounded 3-fold above the basal level at 6h , and again decreased to 0.5-fold of the basal level at 12h , and finally returned to the basal level at 24h . Negative_regulation F2RL1 F2R 11805236 906401 Modified and -2 derived peptides *inhibit* [proteinase activated receptor-2] activation by trypsin . Negative_regulation F3 APOA2 7599177 311420 While the ability of HDL and to *inhibit* [thromboplastin] was unaltered by either Cu2+ oxidation , lipoxygenase oxidation or lipolysis , VLDL and particles resembling VLDL , which acted cooperatively with thromboplastin lost their activating potential . Negative_regulation F3 CPB2 21078613 2474826 The values of prothrombin time (PT) , active partial [thromboplastin] time ( aPTT ) , D-dimer , fibrinogen , plasminogen activator inhibitor 1 ( PAI-1 ) and thrombin-activatable fibrinolysis *inhibitor* ( ) have been measured . Negative_regulation F3 F10 1794748 176211 EPI is a potent inhibitor of the factor [VIIa/thromboplastin (TP)] complex in the *presence* of and is also a direct inhibitor of factor Xa . Negative_regulation F3 F10 2807038 121313 The activity of the extrinsic pathway inhibitor (EPI) , which is the *dependent* inhibitor of the factor VIIa-tissue [thromboplastin] complex , was serially determined in 13 patients with postoperative/posttraumatic septicemia , and compared to the activity of antithrombin ( AT ) , heparin cofactor II and protein C ( PC ) . Negative_regulation F3 F10 3917812 45767 Anticoagulation was thereafter measured , every four hours for 48 hours , by activated partial [thromboplastin] time , thrombin time , and Xa *inhibition* assay . Negative_regulation F3 F11 3917812 45768 Anticoagulation was thereafter measured , every four hours for 48 hours , by activated partial [thromboplastin] time , thrombin time , and Xa *inhibition* assay . Negative_regulation F3 F12 3917812 45769 Anticoagulation was thereafter measured , every four hours for 48 hours , by activated partial [thromboplastin] time , thrombin time , and Xa *inhibition* assay . Negative_regulation F3 F2 3917812 45770 Anticoagulation was thereafter measured , every four hours for 48 hours , by activated partial [thromboplastin] time , thrombin time , and Xa *inhibition* assay . Negative_regulation F3 F3 3917812 45771 Anticoagulation was thereafter measured , every four hours for 48 hours , by activated partial time , thrombin time , and [coagulation factor] Xa *inhibition* assay . Negative_regulation F3 F5 3917812 45772 Anticoagulation was thereafter measured , every four hours for 48 hours , by activated partial [thromboplastin] time , thrombin time , and Xa *inhibition* assay . Negative_regulation F3 F7 2130929 150675 This article also discusses the *role* of recombinant in the treatment of factor VIII deficiency patients with acquired factor VIII inhibitors , factor VII and ischemic heart disease and the factor VII-phospholipid complex , and the regulation of the [thromboplastin-factor] VIIa complex by factor Xa and extrinsic pathway inhibitor (EPI) . Negative_regulation F3 F7 3917812 45773 Anticoagulation was thereafter measured , every four hours for 48 hours , by activated partial [thromboplastin] time , thrombin time , and Xa *inhibition* assay . Negative_regulation F3 F8 3917812 45774 Anticoagulation was thereafter measured , every four hours for 48 hours , by activated partial [thromboplastin] time , thrombin time , and Xa *inhibition* assay . Negative_regulation F3 F9 3917812 45775 Anticoagulation was thereafter measured , every four hours for 48 hours , by activated partial [thromboplastin] time , thrombin time , and Xa *inhibition* assay . Negative_regulation F3 FOXG1 11469787 840931 We herein demonstrate a novel anticoagulant activity of antimicrobial peptide Buforin I (BF I) in offsetting LPS induced mTF hypercoagulation in THP-1 cells , which was confirmed in a cell-free in vitro model , showing that effectively *blocked* rabbit brain [thromboplastin] ( rbTF ) procoagulant activity . Negative_regulation F3 HNF4A 16389552 1539860 *Role* of in control of blood [coagulation factor] gene expression . Negative_regulation F3 LRP1 11150722 758940 This possibility became apparent from the observation that is *involved* in down-regulation of [Tissue Factor] expression at the surface of monocytes and fibroblasts . Negative_regulation F3 LRP10 11150722 758937 This possibility became apparent from the observation that is *involved* in down-regulation of [Tissue Factor] expression at the surface of monocytes and fibroblasts . Negative_regulation F3 LRP11 11150722 758938 This possibility became apparent from the observation that is *involved* in down-regulation of [Tissue Factor] expression at the surface of monocytes and fibroblasts . Negative_regulation F3 LRP12 11150722 758939 This possibility became apparent from the observation that is *involved* in down-regulation of [Tissue Factor] expression at the surface of monocytes and fibroblasts . Negative_regulation F3 LRP2 11150722 758941 This possibility became apparent from the observation that is *involved* in down-regulation of [Tissue Factor] expression at the surface of monocytes and fibroblasts . Negative_regulation F3 LRP3 11150722 758942 This possibility became apparent from the observation that is *involved* in down-regulation of [Tissue Factor] expression at the surface of monocytes and fibroblasts . Negative_regulation F3 LRP4 11150722 758943 This possibility became apparent from the observation that is *involved* in down-regulation of [Tissue Factor] expression at the surface of monocytes and fibroblasts . Negative_regulation F3 LRP5 11150722 758944 This possibility became apparent from the observation that is *involved* in down-regulation of [Tissue Factor] expression at the surface of monocytes and fibroblasts . Negative_regulation F3 LRP6 11150722 758945 This possibility became apparent from the observation that is *involved* in down-regulation of [Tissue Factor] expression at the surface of monocytes and fibroblasts . Negative_regulation F3 LRP8 11150722 758946 This possibility became apparent from the observation that is *involved* in down-regulation of [Tissue Factor] expression at the surface of monocytes and fibroblasts . Negative_regulation F3 PLG 24410816 2907078 Blood samples were collected within 12 hours of the traumatic incident for measurement of blood gases , lactate concentration , platelet count , activated clotting time , prothrombin time , activated partial [thromboplastin] time ( aPTT ) , fibrinogen concentration , antithrombin activity , D-dimer concentration , protein C activity , *inhibition* , plasminogen activity , and kaolin activated thomboelastography . Negative_regulation F3 SERPINE1 15467309 1305762 Bleeding time , platelet count , prothrombin time , activated partial [thromboplastin] time , tissue plasminogen activator (tPA) , plasminogen activator *inhibitor* ( ) , euglobulin clot lysis time , protein C , protein S , fibrinogen , D-dimer , factor V , VII , VIII , IX , X and von Willebrand factor (VWF) values were studied at the beginning , at 2 and 4 h of dialysis with and without administration of DDAVP at a dose level of 2 microg/kg intranasally . Negative_regulation F3 TFPI 10856975 580417 *prevents* further participation of TF in the coagulation process by forming a stable quaternary complex , [TF-FVIIa-FXa-TFPI] . Negative_regulation F3 TFPI 12557438 1029061 [[Tissue factor] ( TF ) and *inhibitor* ( ) concentrations in patients with urinary tract tumors and haematological malignancies ] . Negative_regulation F3 TFPI 2274917 147368 *mediated* inhibition of factor [VIIa/thromboplastin] enzymatic activity is believed to be an important modulator of blood coagulation during hemostasis . Negative_regulation F3 TFPI 2781520 119538 The recombinant is recognized by polyclonal anti-LACI IgG , binds to factor Xa and *inhibits* VII ( a ) [/Tissue Factor] activity in a similar fashion as LACI purified from HepG2 cell conditioned media . Negative_regulation F3 TFPI 8592425 350682 [Tissue factor] activity in the *presence* of absence of was assayed on the luminal surface of dissected human placental arteries , on the advential surface , and also at the site of a microvascular anastomosis . Negative_regulation F5 F3 3917812 45776 Anticoagulation was thereafter measured , every four hours for 48 hours , by activated partial time , thrombin time , and [coagulation factor] Xa *inhibition* assay . Negative_regulation F7 F3 3917812 45777 Anticoagulation was thereafter measured , every four hours for 48 hours , by activated partial time , thrombin time , and [coagulation factor] Xa *inhibition* assay . Negative_regulation F7 TFPI2 18000791 1827043 *inhibits* the tissue [factor/factor VIIa] ( TF/VIIa ) complex and a wide variety of serine proteinases including plasmin , plasma kallikrein , factor XIa , trypsin , and chymotrypsin . Negative_regulation F7 TFPI2 8159751 254340 Preliminary studies indicated that purified recombinant strongly *inhibited* the amidolytic activities of trypsin and the [factor VIIa-tissue] factor complex . Negative_regulation F7 TFPI2 8555184 347341 Recombinant *inhibited* the amidolytic activity of trypsin as well as that of [factor VIIa] in complex with tissue factor . Negative_regulation F8 F3 3917812 45778 Anticoagulation was thereafter measured , every four hours for 48 hours , by activated partial time , thrombin time , and [coagulation factor] Xa *inhibition* assay . Negative_regulation F8 HES2 11395618 823350 Dextran , gelatin , and all can *induce* a specific decrease of von Willebrand factor and [factor VIII] : c. Blood coagulation is most impaired by dextran and high molecular weight HES , both associated with increased postoperative blood loss . Negative_regulation F8 PLAT 1653670 164675 3. Venous blood samples were taken before , during and after the procedure for assay of plasma vasopressin , adrenaline and noradrenaline concentrations , [Factor VIII] coagulant activity , von Willebrand factor antigen level , euglobulin clot lysis time , tissue-type plasminogen activator activity and *inhibition* . Negative_regulation F9 EPHB2 19255327 2051130 Based on the pivotal *role* of signaling and vascular endothelial growth factor ( VEGF ) in [papillary thyroid cancer (PTC)] , we conducted a phase II clinical trial of sorafenib targeting RAF and VEGF receptor kinases in PTC . Negative_regulation F9 F3 3917812 45779 Anticoagulation was thereafter measured , every four hours for 48 hours , by activated partial time , thrombin time , and [coagulation factor] Xa *inhibition* assay . Negative_regulation FABP4 FOXO1 20102700 2213041 Inhibiting expression with FOXO1 siRNA significantly *reduced* basal and PA-induced [FABP4] expression . Negative_regulation FABP4 FOXO1 20102700 2213042 Overexpression of wild-type and constitutively active FOXO1 significantly *increased* [FABP4] expression , whereas dominant negative FOXO1 dramatically decreased FABP4 expression . Negative_regulation FABP4 JAG1 19540436 2099100 In contrast , NICD or transgene expression strongly inhibited adipocyte formation and *reduced* peroxisome proliferator activated receptor-gamma , [fatty acid binding protein 4] , and adiponectin precursor gene expression . Negative_regulation FABP4 TNF 12927809 1131910 and ( 3 ) *inhibited* adiponectin , but paradoxically increased , [aP2] expression in PPAR gamma 2-infected C/EBP alpha null cells . Negative_regulation FADD FAS 10754295 682535 In Faslpr-cg mice , a point mutation in the death domain of *results* in failure to recruit [FADD] ( Fas associated death domain ) , and in the present study this mutation prevented both CD95 mediated apoptosis and p21cip-1/WAF-1 induction . Negative_regulation FADD FAS 12439910 1016882 After SGC-7901 cells were transfected with Fas and FADD antisense oligonucleotides , caspase-8 activity was obviously decreased ( P < 0.01 ) , whereas *blocked* more than [FADD] . Negative_regulation FADD FAS 15214041 1262839 Similarly , cross linking *resulted* in caspase independent translocation of [FADD/MORT1] and caspase-8 to the lipid rafts , which was prevented by a death domain-defective receptor . Negative_regulation FADD FAS 23285096 2711749 However , GTP induced upregulation through activation of c-jun-N-terminal kinase *resulted* in [FADD] phosphorylation , caspase-8 activation and truncation of BID , leading to apoptosis in both LNCaPshV and LNCaPshp53 cells . Negative_regulation FADD FAS 9880544 583994 BTK associates with via its kinase and PH domains and *prevents* the [FAS-FADD] interaction , which is essential for the recruitment and activation of FLICE by Fas during the apoptotic signal . Negative_regulation FADD TNF 15980038 1465270 [FADD] expression also *inhibited* mediated NF-kappaB activation in human endothelial cells but not in rat pulmonary artery smooth muscle cells . Negative_regulation FANCD2 ZFP57 15968973 1353197 Seed-specific expression of these in transgenic soybean somatic embryos *repressed* [FAD2-1] transcription and increased significantly the levels of oleic acid , indicating that the engineered ZFP-TFs are capable of regulating fatty acid metabolism and modulating the expression of endogenous genes in plants . Negative_regulation FAP CLU 22512538 2601995 Overall , our results allow us to postulate a putative protective *role* of in [FAP] , namely in the modulation of TTR aggregate formation . Negative_regulation FAP CLU 22512538 2601998 Future experiments are required to clarify the *role* of in [FAP] . Negative_regulation FAS ACSL3 15556626 1340233 This suggests that the downregulation of [FAS] expression by vitamin D3 is *mediated* by vitamin D3 upregulation of expression . Negative_regulation FAS ADD1 11160371 781721 Moreover , overexpression of by adenoviral gene transfer *induces* [FAS] in chicken adipocytes , where lipogenesis is normally low . Negative_regulation FAS ADIPOQ 19019483 2016913 *inhibits* steatotic [CD95/Fas] up-regulation by hepatocytes : therapeutic implications for hepatitis C . Negative_regulation FAS AFP 15849812 1399215 ( 20 mg/L ) could promote the expression of FasL and TRAIL , and *inhibit* the expression of [Fas] and TRAILR of Bel7402 cells . Negative_regulation FAS AKT1 11733515 904572 Regulation of [Fas] expression by STAT3 and c-Jun is *mediated* by phosphatidylinositol <3-kinase-AKT> signaling . Negative_regulation FAS AKT1 15665818 1369578 In T lymphocytes , the *role* of in regulating [Fas/Fas] ligand (FasL) mediated apoptotic signaling and death is not clearly understood . Negative_regulation FAS AKT2 11733515 904573 Regulation of [Fas] expression by STAT3 and c-Jun is *mediated* by phosphatidylinositol <3-kinase-AKT> signaling . Negative_regulation FAS AKT2 15665818 1369579 In T lymphocytes , the *role* of in regulating [Fas/Fas] ligand (FasL) mediated apoptotic signaling and death is not clearly understood . Negative_regulation FAS AKT3 11733515 904574 Regulation of [Fas] expression by STAT3 and c-Jun is *mediated* by phosphatidylinositol <3-kinase-AKT> signaling . Negative_regulation FAS AKT3 15665818 1369580 In T lymphocytes , the *role* of in regulating [Fas/Fas] ligand (FasL) mediated apoptotic signaling and death is not clearly understood . Negative_regulation FAS ANGPT1 15763944 1352562 Interestingly , the DOX induced up-regulation in Fas ( CD95/APO-1 ) and Fas ligand expression could be blocked by Ang-1 , indicating a pivotal *role* of in DOX induced [Fas] and Fas ligand expression . Negative_regulation FAS ANXA5 11300496 802124 binding , the loss of [Fas] expression from the cell surface as well as zeta down-regulation , which are associated with early apoptosis , were *detected* in a proportion of circulating Fas+CD3+ . Negative_regulation FAS APOB 24209575 2868569 *increased* the number and dynamics of [FAs] and stimulated cell migration in an acid lipase , NPC1 , and Rab8a dependent fashion , providing evidence that this cholesterol delivery route to the PM is important for cell movement . Negative_regulation FAS ARAP2 17077126 1642351 In agreement with the hypothesis that ARAP2 mediates effects of RhoA , endogenous associated with focal adhesions (FAs) and reduction of ARAP2 expression , by RNAi , *resulted* in fewer [FAs] and actin stress fibers ( SFs ) . Negative_regulation FAS ARG1 7493965 335713 When HepG2 cells were fed serum-free media selectively deficient in each amino acid , the omission of any single classic essential amino acid as well as or His ( essential in some rapidly growing cells ) *resulted* in [FAS] mRNA levels that were about half of those in complete medium . Negative_regulation FAS ARG2 7493965 335714 When HepG2 cells were fed serum-free media selectively deficient in each amino acid , the omission of any single classic essential amino acid as well as or His ( essential in some rapidly growing cells ) *resulted* in [FAS] mRNA levels that were about half of those in complete medium . Negative_regulation FAS BAX 12529377 1079124 In human KB epithelial cells expressing the caspase-resistant mutant crBAP31 , [Fas] stimulation resulted in cleavage of BID and insertion of BAX into mitochondrial membrane , but subsequent oligomerization of and BAK , egress of cytochrome c to the cytosol , and apoptosis were *impaired* . Negative_regulation FAS BCL10 21786383 2803012 Western blot analysis demonstrated that propofol promoted [Fas] , cytochrome c , caspase-9 and -3 active form and Bax levels , but *inhibited* protein level which led to cell apoptosis . Negative_regulation FAS BCL10 9468507 486047 functions downstream of caspase-8 to *inhibit* [Fas-] and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells . Negative_regulation FAS BCL10 9468507 486055 In some cells , overexpression can *inhibit* [anti-Fas-] and tumor necrosis factor (TNF)-alpha induced apoptosis . Negative_regulation FAS BCL2 20179890 2215931 As shown in our preliminary study , MCP-1 induced apoptosis of hUVECs in a dose dependent manner at both 24 h and 48 h. FACS and Western blot analysis results in the present study indicated that MCP-1 promoted the expression of proapoptotic proteins Bax and [Fas] and *inhibited* the expression of antiapoptotic protein . Negative_regulation FAS BCL2 21190961 2378966 BCL-6 decreased [Fas] and inducible nitric oxide synthase expression and nitric oxide production , but it *inhibited* the expression of the antiapoptotic proteins and JunB while increasing the expression of the proapoptotic death protein 5 . Negative_regulation FAS BCL2 21786383 2803013 Western blot analysis demonstrated that propofol promoted [Fas] , cytochrome c , caspase-9 and -3 active form and Bax levels , but *inhibited* protein level which led to cell apoptosis . Negative_regulation FAS BCL2 8939996 398725 *prevents* [CD95] ( Fas/APO-1 ) -induced degradation of lamin B and poly ( ADP-ribose ) polymerase and restores the NF-kappaB signaling pathway . Negative_regulation FAS BCL2 9058836 417726 Interestingly , in contrast to the situation found in infected humans , [Fas] ligation by agonistic Abs or recombinant human Fas ligand on CD4 and CD8 T cells from infected chimpanzees did not *induce* apoptosis in these subsets even when was down-regulated . Negative_regulation FAS BCL2 9468507 486048 functions downstream of caspase-8 to *inhibit* [Fas-] and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells . Negative_regulation FAS BCL2 9468507 486056 In some cells , overexpression can *inhibit* [anti-Fas-] and tumor necrosis factor (TNF)-alpha induced apoptosis . Negative_regulation FAS BCL2 9697835 524732 In vitro ligation of Fas on Fas+/+ hMRP8bcl-2 marrow cells depletes approximately 50 % of myeloid progenitor activity , demonstrating that can only partially *block* [Fas] mediated death signals in myelomonocytic progenitors . Negative_regulation FAS BCL2 9766678 538584 After Doxo treatment , enhanced [CD95/CD95-L] expression and caspase-8 activation were not *blocked* by or Bcl-X ( L ) and were found in cells with a mitochondrial transmembrane potential ( delta psi ( m ) ) that was still normal ( delta psi ( m ) high cells ) . Negative_regulation FAS BCL3 21786383 2803014 Western blot analysis demonstrated that propofol promoted [Fas] , cytochrome c , caspase-9 and -3 active form and Bax levels , but *inhibited* protein level which led to cell apoptosis . Negative_regulation FAS BCL3 9468507 486049 functions downstream of caspase-8 to *inhibit* [Fas-] and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells . Negative_regulation FAS BCL3 9468507 486057 In some cells , overexpression can *inhibit* [anti-Fas-] and tumor necrosis factor (TNF)-alpha induced apoptosis . Negative_regulation FAS BCL5 21786383 2803009 Western blot analysis demonstrated that propofol promoted [Fas] , cytochrome c , caspase-9 and -3 active form and Bax levels , but *inhibited* protein level which led to cell apoptosis . Negative_regulation FAS BCL5 9468507 486044 functions downstream of caspase-8 to *inhibit* [Fas-] and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells . Negative_regulation FAS BCL5 9468507 486052 In some cells , overexpression can *inhibit* [anti-Fas-] and tumor necrosis factor (TNF)-alpha induced apoptosis . Negative_regulation FAS BCL6 21786383 2803010 Western blot analysis demonstrated that propofol promoted [Fas] , cytochrome c , caspase-9 and -3 active form and Bax levels , but *inhibited* protein level which led to cell apoptosis . Negative_regulation FAS BCL6 9468507 486045 functions downstream of caspase-8 to *inhibit* [Fas-] and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells . Negative_regulation FAS BCL6 9468507 486053 In some cells , overexpression can *inhibit* [anti-Fas-] and tumor necrosis factor (TNF)-alpha induced apoptosis . Negative_regulation FAS BCL9 21786383 2803011 Western blot analysis demonstrated that propofol promoted [Fas] , cytochrome c , caspase-9 and -3 active form and Bax levels , but *inhibited* protein level which led to cell apoptosis . Negative_regulation FAS BCL9 9468507 486046 functions downstream of caspase-8 to *inhibit* [Fas-] and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells . Negative_regulation FAS BCL9 9468507 486054 In some cells , overexpression can *inhibit* [anti-Fas-] and tumor necrosis factor (TNF)-alpha induced apoptosis . Negative_regulation FAS BCR 9064343 406179 Moreover , cross linking in Lyn-/- B cells *suppressed* [Fas] expression induced by costimulation with CD40 ligand and IL-4 . Negative_regulation FAS BTK 9880544 583992 associates with Fas via its kinase and PH domains and *prevents* the [FAS-FADD] interaction , which is essential for the recruitment and activation of FLICE by Fas during the apoptotic signal . Negative_regulation FAS CA2 7545118 318485 Zn2+ , but not , *prevented* the increase in surface [APO-1L] observed in the presence of 1,10-phenanthroline . Negative_regulation FAS CA2 9529322 496612 These results further define the *role* of in perforin and [FasL/Fas] killing and demonstrate that differential Ca2+ signaling can modulate T cell effector functions . Negative_regulation FAS CALM3 23760276 2820155 Previous studies have shown that calmodulin (CaM) is recruited into the DISC in cholangiocarcinoma cells , suggesting a novel *role* of in [Fas] mediated signaling . Negative_regulation FAS CASP1 11739185 886041 Fas signaling can be interrupted at 3 mains levels : [Fas] clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector *inhibition* of downstream caspase-8 . Negative_regulation FAS CASP1 19111607 2031734 However , recent studies have shown that [Fas] can *induce* nonapoptotic caspase independent cell death (CICD) when activity is inhibited . Negative_regulation FAS CASP1 23935974 2826797 We show that forms a complex with FADD and *diminishes* [Fas-FADD] mediated death signaling . Negative_regulation FAS CASP10 11739185 886042 Fas signaling can be interrupted at 3 mains levels : [Fas] clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector *inhibition* of downstream caspase-8 . Negative_regulation FAS CASP10 19111607 2031735 However , recent studies have shown that [Fas] can *induce* nonapoptotic caspase independent cell death (CICD) when activity is inhibited . Negative_regulation FAS CASP12 11739185 886052 Fas signaling can be interrupted at 3 mains levels : [Fas] clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector *inhibition* of downstream caspase-8 . Negative_regulation FAS CASP12 19111607 2031745 However , recent studies have shown that [Fas] can *induce* nonapoptotic caspase independent cell death (CICD) when activity is inhibited . Negative_regulation FAS CASP14 11739185 886043 Fas signaling can be interrupted at 3 mains levels : [Fas] clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector *inhibition* of downstream caspase-8 . Negative_regulation FAS CASP14 19111607 2031736 However , recent studies have shown that [Fas] can *induce* nonapoptotic caspase independent cell death (CICD) when activity is inhibited . Negative_regulation FAS CASP16 11739185 886053 Fas signaling can be interrupted at 3 mains levels : [Fas] clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector *inhibition* of downstream caspase-8 . Negative_regulation FAS CASP16 19111607 2031746 However , recent studies have shown that [Fas] can *induce* nonapoptotic caspase independent cell death (CICD) when activity is inhibited . Negative_regulation FAS CASP2 11739185 886044 Fas signaling can be interrupted at 3 mains levels : [Fas] clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector *inhibition* of downstream caspase-8 . Negative_regulation FAS CASP2 19111607 2031737 However , recent studies have shown that [Fas] can *induce* nonapoptotic caspase independent cell death (CICD) when activity is inhibited . Negative_regulation FAS CASP3 11739185 886045 Fas signaling can be interrupted at 3 mains levels : [Fas] clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector *inhibition* of downstream caspase-8 . Negative_regulation FAS CASP3 15661884 1365100 In transfected COS7 cells , we confirm that [anti-CD95] mediated death signals are *inhibited* by activation of the CD226 pathway through stabilization of caspase-8 and and through activation of survivin . Negative_regulation FAS CASP3 19111607 2031738 However , recent studies have shown that [Fas] can *induce* nonapoptotic caspase independent cell death (CICD) when activity is inhibited . Negative_regulation FAS CASP4 11739185 886046 Fas signaling can be interrupted at 3 mains levels : [Fas] clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector *inhibition* of downstream caspase-8 . Negative_regulation FAS CASP4 19111607 2031739 However , recent studies have shown that [Fas] can *induce* nonapoptotic caspase independent cell death (CICD) when activity is inhibited . Negative_regulation FAS CASP5 11739185 886047 Fas signaling can be interrupted at 3 mains levels : [Fas] clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector *inhibition* of downstream caspase-8 . Negative_regulation FAS CASP5 19111607 2031740 However , recent studies have shown that [Fas] can *induce* nonapoptotic caspase independent cell death (CICD) when activity is inhibited . Negative_regulation FAS CASP6 11739185 886048 Fas signaling can be interrupted at 3 mains levels : [Fas] clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector *inhibition* of downstream caspase-8 . Negative_regulation FAS CASP6 19111607 2031741 However , recent studies have shown that [Fas] can *induce* nonapoptotic caspase independent cell death (CICD) when activity is inhibited . Negative_regulation FAS CASP7 11739185 886049 Fas signaling can be interrupted at 3 mains levels : [Fas] clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector *inhibition* of downstream caspase-8 . Negative_regulation FAS CASP7 19111607 2031742 However , recent studies have shown that [Fas] can *induce* nonapoptotic caspase independent cell death (CICD) when activity is inhibited . Negative_regulation FAS CASP8 11739185 886050 Fas signaling can be interrupted at 3 mains levels : [Fas] clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector *inhibition* of downstream caspase-8 . Negative_regulation FAS CASP8 12021072 942784 Furthermore , IL-10 treatment activates , a downstream *inhibitor* of [Fas] apoptotic signaling . Negative_regulation FAS CASP8 15661884 1365101 In transfected COS7 cells , we confirm that [anti-CD95] mediated death signals are *inhibited* by activation of the CD226 pathway through stabilization of and caspase-3 and through activation of survivin . Negative_regulation FAS CASP8 18375387 1906952 Lansoprazole also inhibits indomethacin induced Fas mediated mucosal cell death by down regulating [Fas] or FasL expression and *inhibiting* activation . Negative_regulation FAS CASP8 18922907 1977382 The proapoptotic effects of this treatment combination were abrogated by a inhibitor , *led* to increased association of [Fas] and FADD before the onset of cell death , and were significantly reduced in cells transfected with a dominant negative FADD construct or small interfering RNA targeting Fas . Negative_regulation FAS CASP8 19111607 2031743 However , recent studies have shown that [Fas] can *induce* nonapoptotic caspase independent cell death (CICD) when activity is inhibited . Negative_regulation FAS CASP8 22044063 2508291 EA also increased expression of [Fas] , FasL , and c-Jun N-terminal kinase (JNK) , p38 , and mitogen activated protein kinase (MAPK) and decreased expression of extracellular signal regulated kinase ( ERK ) 1/2-p. Co-treatment with the JNK inhibitor SP600125 *inhibited* EA-induced apoptosis and the activation of , -9 , and -3 . Negative_regulation FAS CASP8 22212591 2642695 In addition , cystamine reduced level of [Fas] and *inhibited* activation of . Negative_regulation FAS CASP8 23801068 2854196 The CD95 pathway was performed by flow cytometry , activity measurements , and functional *inhibition* of [CD95] death signaling . Negative_regulation FAS CASP9 11739185 886051 Fas signaling can be interrupted at 3 mains levels : [Fas] clustering , alteration of death-inducing-signaling-complex (DISC) formation , and effector *inhibition* of downstream caspase-8 . Negative_regulation FAS CASP9 19111607 2031744 However , recent studies have shown that [Fas] can *induce* nonapoptotic caspase independent cell death (CICD) when activity is inhibited . Negative_regulation FAS CAT 16880616 1594522 In addition , the IAA/HRP induced activations of [CD95] downstream molecules , i.e. , caspase-8 , Bid , and caspase-3 , were also *inhibited* by . Negative_regulation FAS CCDC88A 21773585 2456815 These findings suggest that the regulation of leptin secretion by may *inhibit* [FAS] activity with subsequent suppression of triglyceride accumulation in the liver and adipose tissues . Negative_regulation FAS CCNG1 12637333 1099233 Similarly , in vivo of NOD-SCID repopulating cells upon transplantation , *resulted* in up-regulation of [Fas] expression . Negative_regulation FAS CD2 8895561 392512 Here we show that enhancer-driven expression of crmA in T lymphocytes of transgenic mice ( CD95-crmA mice ) *reduces*] [Fas ( APO-1/CD95 ) -transduced apoptosis in vitro to the level seen in CD2-deficient mutant lpr mice , but does not protect against gamma-radiation or corticosteroid induced cell death . Negative_regulation FAS CD28 10698621 671896 Stimulation of T cells with DCs at an S/R ratio of 5 *induced* a higher level of expression of [CD95 ligand (CD95L)] than stimulation of T cells cultured with DCs at an S/R ratio of 0.5 , whereas similar levels of expression of and CD154 were observed in both cells . Negative_regulation FAS CD3D 18820644 1987666 We identified the protective factor as prostaglandin E ( 2 ) ( PGE ( 2 ) ) and showed that both APC derived supernatants and PGE ( 2 ) prevented [CD95L] upregulation in T cells in *response* to stimulation , thereby avoiding both AICD and activated T cell killing of target macrophages . Negative_regulation FAS CD3E 18820644 1987667 We identified the protective factor as prostaglandin E ( 2 ) ( PGE ( 2 ) ) and showed that both APC derived supernatants and PGE ( 2 ) prevented [CD95L] upregulation in T cells in *response* to stimulation , thereby avoiding both AICD and activated T cell killing of target macrophages . Negative_regulation FAS CD3G 18820644 1987668 We identified the protective factor as prostaglandin E ( 2 ) ( PGE ( 2 ) ) and showed that both APC derived supernatants and PGE ( 2 ) prevented [CD95L] upregulation in T cells in *response* to stimulation , thereby avoiding both AICD and activated T cell killing of target macrophages . Negative_regulation FAS CD4 8855300 388205 We have found that cross linking *results* in a small but rapid increase in levels of cell surface [Fas] , a member of the tumor necrosis factor receptor family implicated in apoptotic death and maintenance of immune homeostasis . Negative_regulation FAS CD4 9743345 532398 Donor T cell activation in the absence of CD8+ T cell activation *results* in an autoantibody mediated response , no significant [Fas/FasL] up-regulation , impaired elimination of autoreactive B cells , and persistent humoral autoimmunity . Negative_regulation FAS CD40 16897814 1607891 signaling did not *block* association of Fas associated death domain containing protein with [CD95] , but decreased CD95 induced activation of caspases 3 and 8 . Negative_regulation FAS CD40 17376892 1760261 However , even though ligation *results* in up-regulation of [CD95] , ALL blasts , unlike normal B cells , remain resistant to apoptosis . Negative_regulation FAS CD40 21367977 2420686 activation in primary as wells as in KG-1 cells *resulted* in [Fas] up-regulation , providing a mechanism for the CD40 mediated apoptosis . Negative_regulation FAS CD40 8902579 393862 In the course of cognate interaction between CD40 ligand (CD40L) bearing CD4+ T cells and CD40 expressing germinal center B cells , ligation *results* in augmented [Fas] expression at the B cell surface . Negative_regulation FAS CD40 9683298 521426 Activation of neoplastic B cells by ligation *resulted* in significant increases in [Fas] expression and Fas induced apoptosis among the five B-NHL cases tested . Negative_regulation FAS CD40LG 10698621 671895 Stimulation of T cells with DCs at an S/R ratio of 5 *induced* a higher level of expression of [CD95 ligand (CD95L)] than stimulation of T cells cultured with DCs at an S/R ratio of 0.5 , whereas similar levels of expression of CD28 and were observed in both cells . Negative_regulation FAS CD44 14729358 1198384 In the primary cultured cells , TNFalpha *induced* an important upregulation of ICAM-1 , [Fas] and CD40 whereas and CD63 were significantly decreased . Negative_regulation FAS CD44 16555058 1604170 The TM-TNFalpha expressing tumors up-regulated [Fas] ( CD95 ) expression and *inhibited* the expression of tumor metastasis associated molecule . Negative_regulation FAS CD63 14729358 1198385 In the primary cultured cells , TNFalpha *induced* an important upregulation of ICAM-1 , [Fas] and CD40 whereas CD44 and were significantly decreased . Negative_regulation FAS CD74 19968579 2185046 This review describes CD74 protein biology with the emphasis on the *role* of in tumor survival and its new role in regulation of the [Fas] death receptor . Negative_regulation FAS CD79A 9064343 406180 Moreover , cross linking in Lyn-/- B cells *suppressed* [Fas] expression induced by costimulation with CD40 ligand and IL-4 . Negative_regulation FAS CD79B 9064343 406181 Moreover , cross linking in Lyn-/- B cells *suppressed* [Fas] expression induced by costimulation with CD40 ligand and IL-4 . Negative_regulation FAS CDCA2 20373033 2362798 *down-regulated* the expression of [FAS] and HL genes in a dose and time dependent manner in human hepatoma HepG2 cells . Negative_regulation FAS CDCA3 20373033 2362799 *down-regulated* the expression of [FAS] and HL genes in a dose and time dependent manner in human hepatoma HepG2 cells . Negative_regulation FAS CDCA4 20373033 2362800 *down-regulated* the expression of [FAS] and HL genes in a dose and time dependent manner in human hepatoma HepG2 cells . Negative_regulation FAS CDCA5 10754300 682551 expression *inhibited* [Fas] ( CD95 ) - , CD3- , or peptide induced caspase activity in vitro and conferred resistance to Fas induced apoptosis . Negative_regulation FAS CDCA5 20373033 2362801 *down-regulated* the expression of [FAS] and HL genes in a dose and time dependent manner in human hepatoma HepG2 cells . Negative_regulation FAS CDCA7 20373033 2362802 *down-regulated* the expression of [FAS] and HL genes in a dose and time dependent manner in human hepatoma HepG2 cells . Negative_regulation FAS CDCA8 20373033 2362803 *down-regulated* the expression of [FAS] and HL genes in a dose and time dependent manner in human hepatoma HepG2 cells . Negative_regulation FAS CERS6 19483104 2107943 Overexpression of in SW620 cells *enhanced* drug induced [CD95] activation and enhanced tumor cell killing , whereas knockdown of LASS6 in SW480 cells suppressed CD95 activation . Negative_regulation FAS CERS6 19483104 2107944 Knocking down expression also *suppressed* [CD95] activation in hepatoma , pancreatic , and ovarian cancer cells . Negative_regulation FAS CFLAR 19483104 2107937 In SW480 cells , sorafenib + vorinostat increased [CD95] plasma membrane levels and promoted death inducing signal complex (DISC) formation , and drug toxicity was *blocked* by knockdown of CD95 or overexpression of ( c-FLIP-s ) . Negative_regulation FAS CFLAR 21454681 2422559 mediated *inhibition* of [CD95] and TRAIL DR could be of crucial importance during keratinocyte skin carcinogenesis and for the activation of innate and/or adaptive immune responses triggered by DR activation in the skin . Negative_regulation FAS CFTR 22314624 2681249 This study found that deficiency in mice *results* in the upregulation and activation of [CD95] . Negative_regulation FAS CXCL9 8972182 408507 In this study , crmA antagonized , and and Z-VAD-FMK completely *inhibited* , [Fas] activation of p38 kinase activity , demonstrating that Fas dependent activation of p38 requires ICE/CED-3 family members and conversely that the MKK3/p38 activation cascade represents a downstream target for the ICE/CED-3 family proteases . Negative_regulation FAS CYCS 22516057 2700723 Furthermore , dioscin decreased the protein expressions of [Fas/FasL] , increased Bcl-2/Bax ratio , *inhibited* the release of from mitochondrion to cytosol and attenuated CCl ( 4 ) -induced caspase-3 and -8 activities . Negative_regulation FAS DAXX 14517282 1147338 In this study , we investigated the *role* of in [Fas-] and stress induced apoptosis by small interfering RNA mediated Daxx silencing in mammalian cells . Negative_regulation FAS DAXX 14517282 1147341 These data strongly suggest that may *inhibit* [Fas] and stress mediated apoptosis by suppressing proapoptotic gene expression outside of PML domains . Negative_regulation FAS ECM1 20428952 2262567 In summary , we demonstrate that *prevents* activation of [Fas] by epigenetic DNA-methylation . Negative_regulation FAS ECM2 20428952 2262568 In summary , we demonstrate that *prevents* activation of [Fas] by epigenetic DNA-methylation . Negative_regulation FAS EGR1 12556466 1071583 One mechanism was illustrated by the ability of to *inhibit* [CD95] ( Fas/Apo ) expression , leading to insensitivity to FasL . Negative_regulation FAS EPHB2 19180563 2049259 Activated *suppressed* p38 MAPK activation and [Fas/FasL] protein expression . Negative_regulation FAS EPHB2 21227941 2386696 GdA up-regulated the expression of [Fas] and *inhibited* activation in the Th-1 cells , which might enhance the vulnerability of the cells to cell death caused by a trophoblast derived FasL . Negative_regulation FAS EPX 16527892 1574386 *mediated* suppression of erythroblast [Fas] and FasL is a novel stress response pathway that facilitates erythroblast expansion in vivo . Negative_regulation FAS EPX 16539688 1536995 In addition , *reduced* the mRNA level of TNF-alpha , [Fas] and Fas-L , as well as the activities of caspase-8 , 9 and 3 . Negative_regulation FAS FADD 9427646 481709 Dominant negative *inhibits* TNFR60- , [Fas/Apo1-] and TRAIL-R/Apo2 mediated cell death but not gene induction . Negative_regulation FAS FAS 12724420 1084408 FAP-1 association with ( Apo-1 ) *inhibits* [Fas] expression on the cell surface . Negative_regulation FAS FAS 22702503 2615963 DNA fragmentation detected by TUNEL staining could be *induced* by staurosporine and [Fas] activation although only activation resulted in caspase 3 cleavage . Negative_regulation FAS FAS 8509385 221630 All the specific binding of [125I-FAS3] to AChE is *prevented* by as from D. angusticeps venom ( Kd = 0.4 , 14 , and 25 pM , respectively ) . Negative_regulation FAS FAS 9386801 466431 The expression of [Fas] and FasL was not significantly modulated by infection and blocking interactions did not *reduce* the extent of apoptosis . Negative_regulation FAS FAS 9694724 523909 In these cells , TCR triggering induced expression of [Fas] and FasL , and cell death was *prevented* by blocking monoclonal antibody ( MoAb ) . Negative_regulation FAS FASLG 12714260 1083505 Our preliminary results suggest that during aging a subtle balance in the production of molecules that cause apoptosis could exist , and that , in order to avoid an excessive death of immune cells , a still unknown mechanism could compensate the *increase* of [Fas] with the reduction of . Negative_regulation FAS FASLG 14630709 1188073 Altogether , our results highlight the putative *role* of both membrane bound and soluble in oxLDL induced [Fas] and FADD dependent apoptosis of T lymphocytes and suggest an involvement of ROS , ERK , and JNK in this process . Negative_regulation FAS FASLG 15033908 1244018 In NIT-1 insulinoma cells , [Fas] expression induced by the cytokine combination IL-1beta and IFNgamma was *reduced* in the presence of , whereas in islet cells Fas expression was unaffected by FasL . Negative_regulation FAS FASLG 15849812 1399214 AFP ( 20 mg/L ) could promote the expression of and TRAIL , and *inhibit* the expression of [Fas] and TRAILR of Bel7402 cells . Negative_regulation FAS FASLG 21354149 2437959 In cells that expressed a mutant form of Fas in which cysteine 304 was replaced by valine residue , NO-mediated translocation of [Fas] to lipid rafts was affected and the death inducing signal complex and synergistic effect of glyceryl were *inhibited* significantly . Negative_regulation FAS FASLG 22508480 2744713 The effects of treatment and *inhibition* of [Fas] signaling on colorectal and gastric cancer cells were tested using motility assay , immunofluorescence , RT-PCR and immunoblot analyses . Negative_regulation FAS FASLG 23582741 2804358 The effects of treatment and *inhibition* of [Fas] signalling on GI cancer cells were tested using invasion assay , immunofluorescence , immunoblot , Reverse Transcription Polymerase Chain Reaction ( RT-PCR ) , quantitative Real-time PCR ( qRT-PCR ) , immunoprecipitation and luciferase reporter assay . Negative_regulation FAS FASLG 9386801 466432 The expression of [Fas] and FasL was not significantly modulated by infection and blocking interactions did not *reduce* the extent of apoptosis . Negative_regulation FAS FDFT1 8605019 352375 A inhibitor , TAN1607A , decreased both free and esterified cholesterol contents in Hep G2 cells and *increased* mRNA levels for [FAS] , HMG-CoA reductase , squalene synthase and LDL receptor . Negative_regulation FAS FOXP3 21746966 2461750 *mediated* suppression of [CD95L] expression confers resistance to activation induced cell death in regulatory T cells . Negative_regulation FAS GCK 10702802 672717 Conversely , forced expression of the dominant negative form of TRAF2 or in late-stage melanoma cells *reduced* NF-kappaB activity and decreased [Fas] expression , resulting in a lower degree of UV-induced , Fas mediated cell death . Negative_regulation FAS GLA 15607568 1356957 Second , *inhibits* [FAS] activity , thus resulting in the accumulation of cytosolic malonyl-CoA which , in turn , inhibits carnitine palmitoyl transferase I ( CPT-I ) and prevents FA oxidation . Negative_regulation FAS GRAP2 10871852 708321 Inhibition of activity also *restored* NF-kappaB activity and [Fas] expression in early-phase melanoma cells , suggesting that p38 elicited suppression of Fas expression is not restricted to late phase melanoma . Negative_regulation FAS HDAC1 23640463 2779413 Fibroblasts from patients with IPF likewise exhibited decreased histone acetylation and increased H3K9Me3 at the Fas promoter and increased their expression of [Fas] in the *presence* of an inhibitor . Negative_regulation FAS HDAC2 23640463 2779414 Fibroblasts from patients with IPF likewise exhibited decreased histone acetylation and increased H3K9Me3 at the Fas promoter and increased their expression of [Fas] in the *presence* of an inhibitor . Negative_regulation FAS HGF 11141501 770193 We investigated whether Bcl-xL and [Fas/Fas-ligand] were regulated by CsA in cultured podocytes and whether CsA induced apoptosis was *prevented* by or IGF-I . Negative_regulation FAS HGF 9987568 560264 This results suggests that *inhibits* [Fas] mediated apoptotic signals in the endometrium , and possibly plays a role in reshaping the endometrium during menstruation . Negative_regulation FAS HLA-A 16902496 1692097 Interestingly , inhibition of T cell response absolutely *requires* the coexpression of [m-CD95L] and HLA-A1 antigen on the same APC . Negative_regulation FAS HRAS 11809695 906469 Farnesyltransferase inhibitors reverse mediated *inhibition* of [Fas] gene expression . Negative_regulation FAS HRAS 11809695 906472 In previous studies we have shown that oncogenic *inhibits* the expression of [Fas] ( CD95 ) and renders Ras transformed cells resistant to Fas induced death . Negative_regulation FAS HRAS 12389631 1000395 These observations provide evidence for involvement of Raf-1/MEK/ERK pathway in *mediated* inhibition of [Fas] expression and in selective promotion of survival of lymphoma cells . Negative_regulation FAS HSPB1 11193028 761654 The heat shock protein protects cells against a wide variety of toxic treatments and *blocks* apoptosis induced by exposures to anticancer drugs and activation of the death receptor [Fas] . Negative_regulation FAS IFNB1 11698494 878127 Stimulation of the cells with in vitro *resulted* in an even further increase of annexin V binding , as well as increased [Fas] ( CD 95 , APO-1 ) expression . Negative_regulation FAS IFNG 10417150 631469 In the *presence* of and absence of NO , although [Fas] expression was maintained , apoptosis levels were significantly reduced but still higher than those found in splenocytes from uninfected mice , suggesting that Fas-Fas-L interaction could also play a role in apoptosis induction in T. cruzi infected mice . Negative_regulation FAS IFNG 12505729 1038264 PD analyses suggested that in NHS samples containing CsA+SRL ( n=5 ) , ( 1 ) PMA-Ionomycin stimulated T-cell expression of intracellular IL-2 , TNF-alpha , and was inhibited by CsA , and minimally by SRL , and ( 2 ) the two agents *inhibited* pokeweed mitogen ( PWM ) -stimulated B-cell expression of CD54 and [CD95] , but not CD86 ( ICAM-1 , Fas antigen , and B7.2 ) , synergistically . Negative_regulation FAS IFNG 12690298 1078893 Our results indicate that *induces* overexpression of [Fas] and consequently enhances the sensitivity of melanoma cells to Fas mediated apoptosis . Negative_regulation FAS IFNG 14872492 1208438 These findings suggest that *impairs* [CD95] mediated signaling and apoptotic death in human chondrocytes . Negative_regulation FAS IGF1 10903734 713018 also significantly *inhibited* PHA induced [Fas] expression on cord blood T cells . Negative_regulation FAS IGF1 11141501 770194 We investigated whether Bcl-xL and [Fas/Fas-ligand] were regulated by CsA in cultured podocytes and whether CsA induced apoptosis was *prevented* by HGF or . Negative_regulation FAS IGF1 17130467 1652996 expression in IFN-beta expressing beta-cells of double-transgenic mice reduced beta(2)-microglobulin , *blocked* [Fas] expression , and counteracted islet infiltration . Negative_regulation FAS IGF1 9402086 469524 By contrast , decreases apoptosis induced by both serum deprivation and Fas activation and partially *prevents* the increase in [Fas] receptor expression induced by serum deprivation . Negative_regulation FAS IL1B 8573146 349994 [Fas] antigen expression on synovial cells was *down-regulated* by . Negative_regulation FAS IL1B 8573146 349995 Using flowcytometric analysis , *inhibited* [Fas] antigen expression on synovial cells in a dose dependent fashion . Negative_regulation FAS IL2 12505729 1038265 PD analyses suggested that in NHS samples containing CsA+SRL ( n=5 ) , ( 1 ) PMA-Ionomycin stimulated T-cell expression of intracellular , TNF-alpha , and IFN-gamma was inhibited by CsA , and minimally by SRL , and ( 2 ) the two agents *inhibited* pokeweed mitogen ( PWM ) -stimulated B-cell expression of CD54 and [CD95] , but not CD86 ( ICAM-1 , Fas antigen , and B7.2 ) , synergistically . Negative_regulation FAS IL24 21660060 2464762 We demonstrated that ING4 and combination treatment by adenovirus mediated ING4 and IL-24 coexpression *induced* additive growth suppression and apoptosis as well as an overlapping effect on upregulation of P21 , P27 , [Fas] , Bax and cleaved Caspases-8 , 9 , 3 and downregulation of Bcl-2 in in vitro A549 lung carcinoma cells . Negative_regulation FAS IL32 21321117 2410756 Flow cytometry analysis revealed that overexpression of *induced* increased expression of [Fas] and UL16 binding protein 2 (ULBP2) in CML cells . Negative_regulation FAS IL5 11334118 809202 Secondly , the expression of [Fas] on PB-Eos was *suppressed* by ( 18.5 +/- 4.2 % - 8.3 +/- 3.2 % , p < 0.05 ) , whereas IL-5 failed to suppress Fas expression on BAL-Eos ( 3.3 +/- 1.6 % - 3.6 +/- 1.0 % ) . Negative_regulation FAS IL5 9363929 462924 All STO2 derived ECFs and *suppressed* [Fas] expression on eosinophils from PB . Negative_regulation FAS IL7 17404319 1722057 The potential *role* of in [Fas] up-regulation in vivo was verified in IL-7 treated macaques and in HIV infected or chemotherapy treated patients by the correlation between serum IL-7 levels and Fas expression on T cells . Negative_regulation FAS IL7 23610432 2778774 signaling in the presence of sIL7Ra also *diminishes* expression of [CD95] and suppressor of cytokine signaling 1 , both regulatory molecules . Negative_regulation FAS INS 11533263 854662 The purpose of the current study was to examine the *role* of in this exercise down-regulation of [FAS] . Negative_regulation FAS INS 16054098 1438809 We uncover a new mechanism by which acutely *reduces* hepatic [FAS] activity by inducing phosphorylation of the carcinoembryonic antigen related cell adhesion molecule 1 ( CEACAM1 ) and its interaction with FAS . Negative_regulation FAS JUN 12618758 1065874 Ectopic expression of transdominant negative mutants strongly *reduced* [CD95L] promoter activity and activation induced cell death ( AICD ) , confirming the functional significance of FosB/c-Jun binding . Negative_regulation FAS JUN 18373696 1898900 In addition , dominant negative form of *inhibited* radiation induced [Fas] expression and Bax and Bak activation . Negative_regulation FAS JUN 20683948 2299060 The core protein also suppresses apoptosis mediated by Fas ligand because of *dependent* [Fas] down-regulation . Negative_regulation FAS JUNB 21190961 2378965 BCL-6 decreased [Fas] and inducible nitric oxide synthase expression and nitric oxide production , but it *inhibited* the expression of the antiapoptotic proteins Bcl-2 and while increasing the expression of the proapoptotic death protein 5 . Negative_regulation FAS KITLG 9317119 456239 HLA-DR triggered inhibition of hemopoiesis involves [Fas/Fas] ligand interactions and is *prevented* by . Negative_regulation FAS KRAS 11809695 906470 Farnesyltransferase inhibitors reverse mediated *inhibition* of [Fas] gene expression . Negative_regulation FAS KRAS 11809695 906473 In previous studies we have shown that oncogenic *inhibits* the expression of [Fas] ( CD95 ) and renders Ras transformed cells resistant to Fas induced death . Negative_regulation FAS KRAS 12389631 1000396 These observations provide evidence for involvement of Raf-1/MEK/ERK pathway in mediated *inhibition* of [Fas] expression and in selective promotion of survival of lymphoma cells . Negative_regulation FAS KRAS 9829751 551125 However , in the *presence* of oncogenic , survival did not involve down-regulation of [Fas] or FasL expression but did involve members of the Bcl-2 family . Negative_regulation FAS KRT14 9343182 458905 Here we show that , as an early event during infection , the adenovirus complex selectively *induces* loss of [Fas] surface expression and blocks Fas induced apoptosis of virus infected cells . Negative_regulation FAS LEP 18949391 1978901 *enhanced* [anti-Fas] IgM mediated growth inhibition and DNA fragmentation , but did not enhance the expression of either Fas antigen or Fas ligand . Negative_regulation FAS LGALS3 17635791 1770633 Specific targeting of evasion mechanisms displayed in T. cruzi infection , as in vivo [Fas/FasL] blockade or expression *inhibition* , allowed us to modulate B-cell responses enhancing the anti-parasite humoral immune response . Negative_regulation FAS MAP2K1 12389631 1000388 We show that expression of [Fas] in these lymphomas can be increased not only in the presence of a specific inhibitor ( LY294002 ) of P13 kinase , but also in the *presence* of specific inhibitor ( PD98059 ) of , downstream target of Raf-1 . Negative_regulation FAS MAP2K2 12389631 1000389 We show that expression of [Fas] in these lymphomas can be increased not only in the presence of a specific inhibitor ( LY294002 ) of P13 kinase , but also in the *presence* of specific inhibitor ( PD98059 ) of , downstream target of Raf-1 . Negative_regulation FAS MAP2K3 12389631 1000390 We show that expression of [Fas] in these lymphomas can be increased not only in the presence of a specific inhibitor ( LY294002 ) of P13 kinase , but also in the *presence* of specific inhibitor ( PD98059 ) of , downstream target of Raf-1 . Negative_regulation FAS MAP2K4 12389631 1000391 We show that expression of [Fas] in these lymphomas can be increased not only in the presence of a specific inhibitor ( LY294002 ) of P13 kinase , but also in the *presence* of specific inhibitor ( PD98059 ) of , downstream target of Raf-1 . Negative_regulation FAS MAP2K5 12389631 1000392 We show that expression of [Fas] in these lymphomas can be increased not only in the presence of a specific inhibitor ( LY294002 ) of P13 kinase , but also in the *presence* of specific inhibitor ( PD98059 ) of , downstream target of Raf-1 . Negative_regulation FAS MAP2K6 12389631 1000393 We show that expression of [Fas] in these lymphomas can be increased not only in the presence of a specific inhibitor ( LY294002 ) of P13 kinase , but also in the *presence* of specific inhibitor ( PD98059 ) of , downstream target of Raf-1 . Negative_regulation FAS MAP2K7 12389631 1000394 We show that expression of [Fas] in these lymphomas can be increased not only in the presence of a specific inhibitor ( LY294002 ) of P13 kinase , but also in the *presence* of specific inhibitor ( PD98059 ) of , downstream target of Raf-1 . Negative_regulation FAS MAP3K5 11298454 803092 The interaction of Nef with *inhibits* both [Fas-] and TNFalpha mediated apoptosis , as well as the activation of the downstream c-Jun amino-terminal kinase . Negative_regulation FAS MAT2A 19048023 2035382 Inhibition of *induces* FasL expression , [Fas-DISC] formation and caspase-8 dependent apoptotic death in T leukemic cells . Negative_regulation FAS MET 19850829 2224727 To test the effect of a small peptide *inhibitor* ( ) of the [Fas] receptor on the activation of extrinsic and intrinsic apoptosis pathways after retinal detachment . Negative_regulation FAS MET 21421874 2438347 We measured the ability of a Fas activating antibody to induce LC3-I to LC3-II conversion in 661W cells , and the in vivo effect of , a small molecule *inhibitor* of the [Fas] receptor , on LC3-I to LC3-II conversion and Atg5 expression . Negative_regulation FAS MIR23A 23804233 2849244 Mechanistic studies showed that *inhibits* [Fas] expression through a microRNA-23a binding site within the 3'-untranslational region of Fas . Negative_regulation FAS MLXIPL 16184193 1462208 The aim of our study was to assess the *role* of in the control of L-PK and [FAS] gene expression by PUFAs . Negative_regulation FAS MMP2 21573233 2430244 In addition suppression *led* to elevated Fas-L , [Fas] and FADD expression levels along with increased p38 and JNK phosphorylation . Negative_regulation FAS MOK 22543586 2750623 Furthermore , loss of *increased* expression of the death receptor [CD95] ( Fas , Apo-1 ) , CD95 dependent caspase activation and extrinsic apoptosis , whereas NF-kB-p65 nuclear translocation was diminished . Negative_regulation FAS MSH2 11477159 841966 significantly *reduced* the degree of apoptosis , as well as [Fas] and Fas ligand expression ( mean apoptotic cell number , 41.7+/-3.5/14.2+/-2.2 per x200 field at 24 h after ischaemia . Negative_regulation FAS MSH3 11477159 841967 significantly *reduced* the degree of apoptosis , as well as [Fas] and Fas ligand expression ( mean apoptotic cell number , 41.7+/-3.5/14.2+/-2.2 per x200 field at 24 h after ischaemia . Negative_regulation FAS MSH4 11477159 841968 significantly *reduced* the degree of apoptosis , as well as [Fas] and Fas ligand expression ( mean apoptotic cell number , 41.7+/-3.5/14.2+/-2.2 per x200 field at 24 h after ischaemia . Negative_regulation FAS MSH5 11477159 841969 significantly *reduced* the degree of apoptosis , as well as [Fas] and Fas ligand expression ( mean apoptotic cell number , 41.7+/-3.5/14.2+/-2.2 per x200 field at 24 h after ischaemia . Negative_regulation FAS MSH6 11477159 841970 significantly *reduced* the degree of apoptosis , as well as [Fas] and Fas ligand expression ( mean apoptotic cell number , 41.7+/-3.5/14.2+/-2.2 per x200 field at 24 h after ischaemia . Negative_regulation FAS MTOR 18022396 1832112 The use of pharmacological inhibitors revealed that the modulation of Akt , and JNK phosphorylation was *required* for diosgenin induced [FAS] suppression . Negative_regulation FAS MTOR 23585690 2794898 Rapamycin induced inhibition of complex 1 ( mTORC1 ) , a mediator of the feeding/insulin signal to induce lipogenesis , reduced FAS phosphorylation , *increased* cytoplasmic [FAS] enzyme activity , and increased PPARa target gene expression . Negative_regulation FAS MYLIP 21228813 2397640 Indeed ectopic expression of *reduced* , whereas knockdown of endogenous let-7/miR-98 increased the expression of [Fas] at both mRNA and protein levels . Negative_regulation FAS MYLIP 22186140 2549486 Overexpression of consistently *resulted* in the downregulation of [Fas] expression in SAOS-2 cells and thus in decreased sensitivity to FasL . Negative_regulation FAS MYLIP 24356489 2883424 Finally , our data also indicates that could *repress* [Fas] much more potent than miR-23b and the additional region besides conserved seed pairing enables miR-23a 's higher regulation . Negative_regulation FAS NA 12949729 1137145 However , the latter compound as well as , genistein , inhibition of JNK , or protein kinase C *inhibited* [CD95] tyrosine phosphorylation , membrane trafficking , and DISC formation . Negative_regulation FAS NA 8977294 403207 The decrease of [Fas] expression *induced* by was not associated with a modulation of Fas mRNA transcription nor with an internalization , suggesting that NAC may affect the processing of Fas . Negative_regulation FAS NAB1 19407971 2070803 Accordingly , the expression of adipogenic marker genes such as [FAS] , aP2 , PPARgamma , resistin , C/EBPalpha , ADD1/SREBP1c , and adiponectin were *inhibited* by apicidin treatment but not , indicating that the adipocyte differentiation process could be differentially regulated depending on the type of HDAC inhibitor utilized . Negative_regulation FAS NAB2 19407971 2070804 Accordingly , the expression of adipogenic marker genes such as [FAS] , aP2 , PPARgamma , resistin , C/EBPalpha , ADD1/SREBP1c , and adiponectin were *inhibited* by apicidin treatment but not , indicating that the adipocyte differentiation process could be differentially regulated depending on the type of HDAC inhibitor utilized . Negative_regulation FAS NCL 23599269 2795017 Nucleolin knockdown sensitized BJAB cells to Fas ligand (FasL) induced and Fas agonistic antibody induced apoptosis through enhanced binding , suggesting that *blocks* the [FasL-Fas] interaction . Negative_regulation FAS NFKB1 12761580 1091675 On the other hand , [Fas] expression was strongly *enhanced* by TNF/IFN-alpha , and inhibition of TNF/IFN-alpha induced activation , by using NF-kappaB decoy , decreased Fas expression . Negative_regulation FAS NFKB1 15033727 1184086 Overall , these data suggest that inhibition may *restore* the [Fas-pathway] in Fas-resistant NF-kappaB overexpressing tumors . Negative_regulation FAS NFKB1 15117910 1252038 Hcy increased DNA binding activity , and adenovirus mediated transfection of a Ikappa-B mutant ( Ikappa-B mt ) gene *inhibited* Hcy induced [Fas] expression . Negative_regulation FAS NFKB1 15601669 1375274 We studied the *role* of the transcription factor and of MAPKs in regulating [Fas] expression . Negative_regulation FAS NFKBIA 19710540 2127335 Overexpression of by transient transfection or inhibition of NF-kappaB by BAY11-7082 *suppressed* HDGF knock-down effect on fas promoter activation , [Fas] up-regulation , apoptosis induction and growth suppression . Negative_regulation FAS NOS2 20541824 2301950 Silencing by RNAi *prevented* the up-regulation of Bax and [Fas] induced by cytokine , thus reduced apoptosis of islets and recovered the insulin secretion index ( 3.43+/-0.24 vs 1.87+/-0.31 , P < 0.01 ) . Negative_regulation FAS NPY6R 15039424 1251282 SU6656 but not also *inhibited* EGFR/CD95 association , [CD95] tyrosine phosphorylation , CD95 membrane trafficking , and death inducing signaling complex (DISC) formation . Negative_regulation FAS NRAS 11809695 906471 Farnesyltransferase inhibitors reverse *mediated* inhibition of [Fas] gene expression . Negative_regulation FAS NRAS 11809695 906474 In previous studies we have shown that oncogenic *inhibits* the expression of [Fas] ( CD95 ) and renders Ras transformed cells resistant to Fas induced death . Negative_regulation FAS NRAS 12389631 1000397 These observations provide evidence for involvement of Raf-1/MEK/ERK pathway in *mediated* inhibition of [Fas] expression and in selective promotion of survival of lymphoma cells . Negative_regulation FAS PCNA 15052671 1229817 VES inhibited the growth of gastric cancer cells by inducing [Fas] expression and *inhibiting* expression . Negative_regulation FAS PCNA 18483205 1939087 Our data indicate that in human CD8+ T-cell blasts , [Fas] ligation , and especially Apo2L/TRAIL *induce* the p53 dependent decrease in levels . Negative_regulation FAS PCNA 23671449 2785109 Meanwhile , EsA reduced the serum IL-6 and TNF-a levels ( p < 0.05 ) , *inhibited* the expression of and promoted the expression of caspase-3 , [Fas] and FasL in animals of the treated group ( p < 0.05 ) . Negative_regulation FAS PEA15 10588860 572151 The phosphoprotein protein *inhibits* [Fas-] but increases TNF-R1 mediated caspase-8 activity and apoptosis . Negative_regulation FAS PIK3CA 11733515 904575 Regulation of [Fas] expression by STAT3 and c-Jun is *mediated* by signaling . Negative_regulation FAS PIK3CA 18403639 1893858 Herein , we show that inhibition of the signal by edelfosine *triggers* a [Fas] mediated apoptotic signal independently of the Fas/FasL interaction . Negative_regulation FAS PIK3R1 11733515 904576 Regulation of [Fas] expression by STAT3 and c-Jun is *mediated* by signaling . Negative_regulation FAS PIK3R1 18403639 1893859 Herein , we show that inhibition of the signal by edelfosine *triggers* a [Fas] mediated apoptotic signal independently of the Fas/FasL interaction . Negative_regulation FAS POLDIP2 10871852 708324 Identifying *mediated* down-regulation of [Fas] expression illustrates a novel regulatory pathway by which ASK1/MKK6/p38 alters the degree and nature of the UV-induced apoptosis of melanoma cells . Negative_regulation FAS PPARA 9558724 500195 However , the potent activators ETYA and Wy-14643 did not *suppress* hepatic expression of [FAS] , but did induce the PPAR-responsive gene , acyl-CoA oxidase (AOX) . Negative_regulation FAS PPP1R3A 22975510 2674008 In these two stimuli induced apoptotic cells , *down-regulated* [Fas] gene expression , while Rb1 decreased Caspase-3 gene expression . Negative_regulation FAS PPP2CA 20631069 2297395 ROS generation , [CD95] *activation* , and cell killing was also blocked by quenching of induced Ca ( 2+ ) levels or by inhibition of . Negative_regulation FAS PPP2R1A 20631069 2297396 ROS generation , [CD95] *activation* , and cell killing was also blocked by quenching of induced Ca ( 2+ ) levels or by inhibition of . Negative_regulation FAS PPP2R2B 20631069 2297397 ROS generation , [CD95] *activation* , and cell killing was also blocked by quenching of induced Ca ( 2+ ) levels or by inhibition of . Negative_regulation FAS PPP3CA 10064053 593336 Regulation of cell surface expression of [Fas] ( CD95) ligand and susceptibility to Fas ( CD95 ) -mediated apoptosis in activation induced T cell death *involves* and protein kinase C , respectively . Negative_regulation FAS PPP3CB 10064053 593337 Regulation of cell surface expression of [Fas] ( CD95) ligand and susceptibility to Fas ( CD95 ) -mediated apoptosis in activation induced T cell death *involves* and protein kinase C , respectively . Negative_regulation FAS PPP3CC 10064053 593338 Regulation of cell surface expression of [Fas] ( CD95) ligand and susceptibility to Fas ( CD95 ) -mediated apoptosis in activation induced T cell death *involves* and protein kinase C , respectively . Negative_regulation FAS PRH2 23799838 2802859 [FAs] were mobilized according to their structure , such that for a given CL , mobilization *increased* with the number of , and for a given number of DBs , mobilization decreased as CL increased . Negative_regulation FAS PRL 15983196 1424807 Taken together , these data strongly suggest that directly *represses* expression of [FAS] in adipocytes through STAT5A binding to the -908 to -893 site . Negative_regulation FAS PTEN 11830512 909944 Consistent with these findings , reintroduction of *results* in decreased levels of [FAS] expression in a manner that is dependent on its lipid phosphatase activity . Negative_regulation FAS PTEN 22949843 2667191 Upregulating expression and *inhibiting* [FAS] expression may offer a novel therapeutic approach for HCC . Negative_regulation FAS PTPN13 12724420 1084409 Forced expression of *reduces* cell surface [Fas] levels and increases the intracellular pool of Fas within the cytoskeleton network . Negative_regulation FAS PXN 9658172 516984 An avian paxillin-CHO.K1 model system was used to explore the *role* of phosphorylation in paxillin localization to [FAs] . Negative_regulation FAS QRICH1 12165276 972773 Meanwhile , *down-regulated* [CD95] and CD95L expression , but up-regulated CD45RO and Bcl-2 expression in activated T cells . Negative_regulation FAS QRICH1 12198652 982205 Hyperosmotic [CD95] targeting to the plasma membrane was dose-dependently *diminished* by or taurine , probably caused by an augmentation of volume regulatory increase . Negative_regulation FAS QRICH2 12165276 972774 Meanwhile , *down-regulated* CD95 and [CD95L] expression , but up-regulated CD45RO and Bcl-2 expression in activated T cells . Negative_regulation FAS QRICH2 12198652 982206 Hyperosmotic [CD95] targeting to the plasma membrane was dose-dependently *diminished* by or taurine , probably caused by an augmentation of volume regulatory increase . Negative_regulation FAS RBBP4 23640463 2779415 Fibroblasts from patients with IPF likewise exhibited decreased histone acetylation and increased H3K9Me3 at the Fas promoter and increased their expression of [Fas] in the *presence* of an inhibitor . Negative_regulation FAS RBBP7 23640463 2779416 Fibroblasts from patients with IPF likewise exhibited decreased histone acetylation and increased H3K9Me3 at the Fas promoter and increased their expression of [Fas] in the *presence* of an inhibitor . Negative_regulation FAS REL 9846183 553848 *blocks* both [anti-Fas-] and TNF alpha induced apoptosis and an intact Rel transactivation domain is essential for this effect . Negative_regulation FAS RELA 12761580 1091676 On the other hand , [Fas] expression was strongly *enhanced* by TNF/IFN-alpha , and inhibition of TNF/IFN-alpha induced activation , by using NF-kappaB decoy , decreased Fas expression . Negative_regulation FAS RELA 15033727 1184087 Overall , these data suggest that inhibition may *restore* the [Fas-pathway] in Fas-resistant NF-kappaB overexpressing tumors . Negative_regulation FAS RELA 15117910 1252039 Hcy increased DNA binding activity , and adenovirus mediated transfection of a Ikappa-B mutant ( Ikappa-B mt ) gene *inhibited* Hcy induced [Fas] expression . Negative_regulation FAS RELA 15601669 1375275 We studied the *role* of the transcription factor and of MAPKs in regulating [Fas] expression . Negative_regulation FAS RNPEP 23049237 2684844 Furthermore , HG increased JNK phosphorylation and [Fas] expression , and both responses were partially *blocked* by <2-APB> and KN93 , while the JNK inhibitor SP600125 partially reduced HG-induced Fas expression . Negative_regulation FAS SBDS 19009351 2016509 These results suggest that loss *results* in abnormal accumulation of [Fas] at the plasma membrane , where it sensitizes the cells to stimulation by Fas ligand . Negative_regulation FAS SERPINB9 10529613 561992 The expression of [Fas] on PB-Eos was significantly *suppressed* by ( 18.5 to 7.37 % , p < 0. 05 ) , whereas ECF-PI9 failed to suppress the Fas expression on BAL-Eos ( 3.3 to 3.6 % ) . Negative_regulation FAS SERPINB9 16179941 1517501 The *role* of in [CD95] signaling : new insights into the mechanism of procaspase-8 activation . Negative_regulation FAS SIK2 18239551 1877035 Reduction of endogenous expression through RNA interference *increased* the expression of [FAS] , ACC2 , and SCD1 . Negative_regulation FAS SIK2 18239551 1877037 *inhibits* the expression of [FAS-promoter] driven luciferase reporter gene , and this effect can be reversed by overexpression of constitutively active sterol regulatory element binding protein-1 ( SREBP-1 ) . Negative_regulation FAS SMO 15492281 1321573 Conversely , expression of activated in C3H10T1/2 cells *inhibits* [Fas] expression . Negative_regulation FAS SOCS1 15100317 1239743 [Fas] expression was up-regulated on beta cells in vivo in prediabetic NOD8 .3 mice , and this was *inhibited* by . Negative_regulation FAS SOCS1 19015667 2035063 overexpression *prevented* [Fas] upregulation on NOD4.1 beta-cells , but did not prevent islet destruction because SOCS1 transgenic islets were killed when grafted into NOD4.1.scid mice . Negative_regulation FAS SOD1 15909112 1409486 *inhibits* [FAS] expression in cortex of APP transgenic mice . Negative_regulation FAS SOD1 15909112 1409487 This study indicates that overexpression can *inhibit* [FAS] expression , which may be beneficial in AD . Negative_regulation FAS SREBF1 11064454 746892 Deletion or mutation of this binding site abolishes these effects and ectopic expression of dominant negative *inhibits* [FAS] expression and induction in intact LNCaP cells . Negative_regulation FAS SREBF1 11160371 781720 Moreover , overexpression of by adenoviral gene transfer *induces* [FAS] in chicken adipocytes , where lipogenesis is normally low . Negative_regulation FAS SREBF1 16162944 1475993 In addition , overexpression of active directly *stimulated* SCD-1 and [FAS] . Negative_regulation FAS SREBF1 23349077 2754067 CDCQ strongly *inhibited* high glucose induced [FAS] expression by modulating activation . Negative_regulation FAS SRL 12505729 1038262 PD analyses suggested that in NHS samples containing CsA+SRL ( n=5 ) , ( 1 ) PMA-Ionomycin stimulated T-cell expression of intracellular IL-2 , TNF-alpha , and IFN-gamma was inhibited by CsA , and minimally by , and ( 2 ) the two agents *inhibited* pokeweed mitogen ( PWM ) -stimulated B-cell expression of CD54 and [CD95] , but not CD86 ( ICAM-1 , Fas antigen , and B7.2 ) , synergistically . Negative_regulation FAS STAT3 14617800 1200870 Phosphorylation of the transcription factor on Ser-727 , mediated by the extracellular signal regulated kinase MAP kinase pathway , may *contribute* to the decrease in both Bax and [Fas] expression in p38 alpha-/- cells . Negative_regulation FAS STAT3 25083589 2954008 We propose that tectochrysin leads to apoptotic cell death in NSCLC cells through *activation* of DR3 and [Fas] expression via inhibition of phosphorylation . Negative_regulation FAS TANK 10702802 672716 Conversely , forced expression of the dominant negative form of or GCK in late-stage melanoma cells *reduced* NF-kappaB activity and decreased [Fas] expression , resulting in a lower degree of UV-induced , Fas mediated cell death . Negative_regulation FAS TGFB1 14654978 1188455 Second , *up-regulated* [Fas] signaling pathway inhibitor cFLIPL to block the pro-caspase-8 cleavage and thus promoted survival of leukaemia/lymphoma cells . Negative_regulation FAS TIMP1 20595097 2334427 Moreover , significantly *inhibited* both [Fas-] and activation induced cell death of lymphocytes . Negative_regulation FAS TIMP3 15879156 1406161 Gene transfer of inhibits the TNF-alpha induced activation of NF-kappaB in rheumatoid arthritis synovial fibroblasts and *reduces* the up-regulation of soluble [Fas/CD95] by TNF-alpha , but has no effects on the cell surface expression of Fas . Negative_regulation FAS TNF 10704256 672822 Moreover , removal of activity by a neutralizing anti-TNF-alpha antibody ( cA2 ) *restored* [Fas-ACD] . Negative_regulation FAS TNF 10704256 672824 These results suggest the following : ( 1 ) [Fas-ACD] might be *diminished* in vivo by local excessive and this might contribute in part to RASH . Negative_regulation FAS TNF 11561906 862727 TGF-beta as well as *reduced* spontaneous apoptosis and [CD95L] expression . Negative_regulation FAS TNF 12505729 1038263 PD analyses suggested that in NHS samples containing CsA+SRL ( n=5 ) , ( 1 ) PMA-Ionomycin stimulated T-cell expression of intracellular IL-2 , , and IFN-gamma was inhibited by CsA , and minimally by SRL , and ( 2 ) the two agents *inhibited* pokeweed mitogen ( PWM ) -stimulated B-cell expression of CD54 and [CD95] , but not CD86 ( ICAM-1 , Fas antigen , and B7.2 ) , synergistically . Negative_regulation FAS TNF 12761580 1091674 On the other hand , [Fas] expression was strongly *enhanced* by TNF/IFN-alpha , and inhibition of induced NF-kappaB activation , by using NF-kappaB decoy , decreased Fas expression . Negative_regulation FAS TNF 14596819 1160342 Results indicated that FB1 can *induce* [CD95] modulated signaling when is absent . Negative_regulation FAS TNF 21816064 2472809 High glucose induced up-regulation of TNF-R1 and [Fas] expression was undetectable in the *presence* of . Negative_regulation FAS TNFAIP3 16646083 1563150 expression significantly *attenuated* the increased expression of [Fas] and FasL , and Fas mediated apoptosis . Negative_regulation FAS TNFRSF25 17898502 1802947 The results indicate that the high linolenic *suppressed* hepatic [FAS] activity compared with the control lard , resulting in a lower concentration of plasma TAG . Negative_regulation FAS TNFSF10 15849812 1399213 AFP ( 20 mg/L ) could promote the expression of FasL and , and *inhibit* the expression of [Fas] and TRAILR of Bel7402 cells . Negative_regulation FAS TNFSF11 15619676 1357674 In differentiated mature osteoclasts , *reduces* the levels of [Fas] expression and Fas mediated apoptosis , acting as a survival factor . Negative_regulation FAS TP53 11793363 901977 However , the *role* of wild-type in [Fas] expression is still controversial . Negative_regulation FAS TP53 12397013 1008707 Expression of dominant negative also *inhibited* the [Fas] translocation induced by H ( 2 ) O ( 2 ) in A549 cells . Negative_regulation FAS TP53 12944915 1136124 Excess mutant *represses* the transcriptional activity of the [CD95] promoter , with the extent of repression varying among different tumor associated p53 mutants . Negative_regulation FAS TP53 14612511 1163334 *Role* of in regulating constitutive and X-radiation-inducible [CD95] expression and function in carcinoma cells . Negative_regulation FAS TP53 14612511 1163336 However , whether *dependent* regulation of [CD95] expression is consistently associated with increased susceptibility to CD95 mediated cell death is poorly understood . Negative_regulation FAS TP53 15207713 1261658 The observation that overexpression of by Adp53 infection in MCF-7 does not *induce* increased [Fas] protein levels nor apoptotic cell death suggests that p53 overexpression is required but not sufficient enough for apoptosis . Negative_regulation FAS TP53 20233581 2237951 This is due to *repression* of [CD95] gene transcription by mutant . Negative_regulation FAS TRAF2 10229103 610954 Nonetheless , a functional link between TRAF2 and IKK activity in B cells is demonstrated by the fact that overexpression of constitutively *induces* IKK activity , NF-kappaB luciferase and [Fas] expression . Negative_regulation FAS TYMS 15161716 1252882 Induction of expression *inhibited* [Fas] induction in response to RTX and Alimta , but not in response to 5-FU . Negative_regulation FAS USF1 11583420 865619 These results suggest that a STRE may be located within the first 112 bp of the FAS promoter and that does not directly *mediate* the effect of ST on transcription of the [FAS] gene in 3T3-F442A adipocytes . Negative_regulation FAS VCL 16584805 1562500 Expression of rescued the spreading defect and *resulted* in larger and more stable [FAs] . Negative_regulation FAS VEGFA 10475096 642706 The same effect was found with Fas-ligation , although at high concentrations [Fas-ligation] *induced* no further increase , but even a decrease of expression , possibly related to cell damage . Negative_regulation FAS VEGFA 16528471 1568090 Caspase-3 , Bax , [Fas] , and 85-kDa apoptosis related cleavage fragments were clearly *reduced* by . Negative_regulation FAS YY1 16081784 1442832 Inhibition of activity by either rituximab or the NO donor DETANONOate or after transfection with YY1 small interfering RNA *resulted* in up-regulation of [Fas] expression and sensitization to CH-11 induced apoptosis . Negative_regulation FAS YY1 16103877 1488991 Inhibition of *resulted* in the upregulation of [Fas] expression and sensitization of the tumor cells to CH-11 induced apoptosis . Negative_regulation FAS YY1 16143308 1454921 The direct *role* of in the negative regulation of [Fas] expression was demonstrated by transfection of cells with siRNA YY1 . Negative_regulation FASLG ANGPT1 15763944 1352563 Interestingly , the DOX induced up-regulation in Fas ( CD95/APO-1 ) and Fas ligand expression could be blocked by Ang-1 , indicating a pivotal *role* of in DOX induced Fas and [Fas ligand] expression . Negative_regulation FASLG ANGPT1 23554782 2714256 Specifically , *prevented* DOX induced increases in [FasL] and Bax levels and cleaved caspase-3 and caspase-8 levels in H9C2 cells . Negative_regulation FASLG EPHB2 19180563 2049260 Activated *suppressed* p38 MAPK activation and [Fas/FasL] protein expression . Negative_regulation FASLG EPHB2 19864500 2187793 Moreover , alone *suppressed* TNF-alpha and [FasL] and inhibited TNF-family mediated extrinsic apoptosis in H9N2 infected chicken macrophages . Negative_regulation FASLG EPHB2 23371318 2803613 Similarly , - but not NF-?B - *inhibited* [Fas ligand] and TNF-a mediated apoptosis responses in both cell line experiments and primary IECs . Negative_regulation FASLG FAS 11261797 794556 We analyzed inflamed muscles of normal mice treated from day 3 to day 8 with a [FasL] *inhibitor* ( ) or with control Ig . Negative_regulation FASLG FAS 11716096 881633 Conversely , eosinophils from the granuloma and spleens of S. mansoni infected mice are resistant to apoptosis in vivo and are protected in vitro from Fas-FasL mediated apoptosis by the absence of [FasL] expression in the *presence* of expression . Negative_regulation FASLG FAS 15297380 1296773 Mice were transfected with adenovirus encoding soluble ( sFas ) , a competitive *inhibitor* of [Fas ligand] , on the third day of MI . Negative_regulation FASLG FAS 15849812 1399217 AFP ( 20 mg/L ) could promote the expression of [FasL] and TRAIL , and *inhibit* the expression of and TRAILR of Bel7402 cells . Negative_regulation FASLG FAS 19066339 2035573 We determined whether interruption of Fas/FasL interaction by cardiac targeted expression of soluble ( sFas ) , a competitive *inhibitor* of [FasL] , would protect against Dox chronic cardiotoxicity in mice . Negative_regulation FASLG FAS 19811416 2148628 The soluble form of ( sFas ) produced by alternative mRNA splicing may *inhibit* [Fas-Fas Ligand] binding and apoptosis . Negative_regulation FASLG FAS 8603437 352184 These results demonstrate that FasL gene activation , but not up-regulation , is critical for AICD and that Dex and all-trans RA selectively *inhibits* [FasL] but not Fas function . Negative_regulation FASLG FAS 9268499 450021 In addition , we found that the apparent level of FasL mediated cytotoxic activity in the 2 degrees lpr CD4+ T cell population is much higher than that of wild-type cells , suggesting that deficient expression *leads* to inordinately high levels of [FasL] expression or subsaturation of FasL binding sites . Negative_regulation FASLG FAS 9386801 466433 The expression of Fas and [FasL] was not significantly modulated by infection and blocking interactions did not *reduce* the extent of apoptosis . Negative_regulation FASLG FAS 9694724 523910 In these cells , TCR triggering induced expression of Fas and [FasL] , and cell death was *prevented* by blocking monoclonal antibody ( MoAb ) . Negative_regulation FASLG MMP28 15581951 1345206 Flow cytometry showed that LPA strongly upregulated FasL expression on the OVCAR3 cell surface ( P < 0.01 ) , yet in Dov13 cells , LPA significantly upregulated [FasL] expression only in the *presence* of the general inhibitors GM6001 and MMP inhibitor II ( P < 0.01 ) . Negative_regulation FASLG MMP7 11212252 785783 efficiently cleaved recombinant FasL in vitro and *reduced* cell surface [FasL] expression . Negative_regulation FASLG MMP7 15581951 1345221 Flow cytometry showed that LPA strongly upregulated FasL expression on the OVCAR3 cell surface ( P < 0.01 ) , yet in Dov13 cells , LPA significantly upregulated [FasL] expression only in the *presence* of the general inhibitors GM6001 and MMP inhibitor II ( P < 0.01 ) . Negative_regulation FASLG TNF 11549697 856863 Interestingly , expression of the [Fas ligand] , a known inductor of testicular apoptosis , was *down-regulated* by . Negative_regulation FASN EPHB2 25086185 2956902 Inhibition of [fatty acid synthase] *induces* pro-survival Akt and signaling in K-Ras-driven cancer cells . Negative_regulation FASN FOXO1 16997836 1640795 Increased activity *resulted* in up-regulation of hepatic peroxisome proliferator activated receptor-gamma coactivator-1beta , [fatty acid synthase] , and acetyl CoA carboxylase expression , accounting for increased hepatic fat infiltration . Negative_regulation FASN TNF 16439103 1521639 However , in cell culture experiments using the human intestinal cell line LS174T induction of [fatty acid synthase] by the LXR ligand T0901317 was *inhibited* by . Negative_regulation FBLN1 TNF 19230968 2050493 Furthermore , *inhibited* amnion cell [fibulin] production in a dose dependent manner . Negative_regulation FBLN2 TNF 19230968 2050494 Furthermore , *inhibited* amnion cell [fibulin] production in a dose dependent manner . Negative_regulation FBLN5 TNF 19230968 2050495 Furthermore , *inhibited* amnion cell [fibulin] production in a dose dependent manner . Negative_regulation FBLN7 TNF 19230968 2050492 Furthermore , *inhibited* amnion cell [fibulin] production in a dose dependent manner . Negative_regulation FBXO32 AKT1 15109499 1240869 IGF-1 treatment or overexpression *inhibits* Foxo and [atrogin-1] expression . Negative_regulation FBXO32 AKT1 15125842 1244679 a mutant form of FOXO1 , which prevents Akt phosphorylation , thereby prevents mediated *inhibition* of MuRF1 and [MAFbx] upregulation . Negative_regulation FBXO32 AKT1 20228261 2254436 Dominant negative and constitutively active Foxo-1 *blocked* the ability of IGF-1 to prevent ANG II-mediated upregulation of [atrogin-1] and skeletal muscle wasting . Negative_regulation FBXO32 AKT1 24002653 2856138 To accomplish this goal , in vivo transfection of plasmid DNA was used to create transient transgenic mouse skeletal muscles , and our results show for the first time that Smad3 expression is sufficient to stimulate [atrogin-1] promoter activity , *inhibit* signaling and protein synthesis , and induce muscle fiber atrophy . Negative_regulation FBXO32 AKT2 15109499 1240870 IGF-1 treatment or overexpression *inhibits* Foxo and [atrogin-1] expression . Negative_regulation FBXO32 AKT2 15125842 1244680 a mutant form of FOXO1 , which prevents Akt phosphorylation , thereby prevents mediated *inhibition* of MuRF1 and [MAFbx] upregulation . Negative_regulation FBXO32 AKT2 20228261 2254437 Dominant negative and constitutively active Foxo-1 *blocked* the ability of IGF-1 to prevent ANG II-mediated upregulation of [atrogin-1] and skeletal muscle wasting . Negative_regulation FBXO32 AKT2 24002653 2856139 To accomplish this goal , in vivo transfection of plasmid DNA was used to create transient transgenic mouse skeletal muscles , and our results show for the first time that Smad3 expression is sufficient to stimulate [atrogin-1] promoter activity , *inhibit* signaling and protein synthesis , and induce muscle fiber atrophy . Negative_regulation FBXO32 AKT3 15109499 1240871 IGF-1 treatment or overexpression *inhibits* Foxo and [atrogin-1] expression . Negative_regulation FBXO32 AKT3 15125842 1244681 a mutant form of FOXO1 , which prevents Akt phosphorylation , thereby prevents *mediated* inhibition of MuRF1 and [MAFbx] upregulation . Negative_regulation FBXO32 AKT3 20228261 2254438 Dominant negative and constitutively active Foxo-1 *blocked* the ability of IGF-1 to prevent ANG II-mediated upregulation of [atrogin-1] and skeletal muscle wasting . Negative_regulation FBXO32 AKT3 24002653 2856140 To accomplish this goal , in vivo transfection of plasmid DNA was used to create transient transgenic mouse skeletal muscles , and our results show for the first time that Smad3 expression is sufficient to stimulate [atrogin-1] promoter activity , *inhibit* signaling and protein synthesis , and induce muscle fiber atrophy . Negative_regulation FBXO32 CASQ1 24243720 2897993 Ectopic expression of in C2C12 myoblast *resulted* in decreased activity of nuclear factor of activated T-cells and increased levels of [atrogin-1] and MuRF1 E3 ligase , suggesting that these differentially expressed proteins are involved in muscle aging . Negative_regulation FBXO32 CASQ2 24243720 2897994 Ectopic expression of in C2C12 myoblast *resulted* in decreased activity of nuclear factor of activated T-cells and increased levels of [atrogin-1] and MuRF1 E3 ligase , suggesting that these differentially expressed proteins are involved in muscle aging . Negative_regulation FBXO32 FOXO1 19553561 2128952 activation *resulted* in a significant increase in [muscle atrophy F-box (MAFbx)/atrogin-1] , muscle-specific RING finger protein 1 ( MuRF-1 ) , and Bcl-2 interacting mediator of cell death ( Bim ) gene expression , with no significant increase in Bcl-2/adenovirus E1B 19-kDa interacting protein 3 ( BNip3 ) gene expression . Negative_regulation FBXO32 FOXO1 20228261 2254418 IGF-1 prevents ANG II-induced skeletal muscle atrophy via Akt- and dependent *inhibition* of the ubiquitin ligase [atrogin-1] expression . Negative_regulation FBXO32 FOXO1 20228261 2254435 Dominant negative Akt and constitutively active *blocked* the ability of IGF-1 to prevent ANG II-mediated upregulation of [atrogin-1] and skeletal muscle wasting . Negative_regulation FBXO32 FOXO1 22102632 2557431 Expression of DN *inhibited* the increased mRNA levels of [atrogin-1] , MuRF1 , cathepsin L , and/or Bnip3 and inhibited muscle fiber atrophy during cancer cachexia and sepsis . Negative_regulation FBXO32 FOXO3 20228261 2254419 IGF-1 prevents ANG II-induced skeletal muscle atrophy via Akt- and dependent *inhibition* of the ubiquitin ligase [atrogin-1] expression . Negative_regulation FBXO32 FOXO3 22102632 2557432 Expression of DN *inhibited* the increased mRNA levels of [atrogin-1] , MuRF1 , cathepsin L , and/or Bnip3 and inhibited muscle fiber atrophy during cancer cachexia and sepsis . Negative_regulation FBXO32 FOXO4 20228261 2254420 IGF-1 prevents ANG II-induced skeletal muscle atrophy via Akt- and dependent *inhibition* of the ubiquitin ligase [atrogin-1] expression . Negative_regulation FBXO32 FOXO4 22102632 2557433 Expression of DN *inhibited* the increased mRNA levels of [atrogin-1] , MuRF1 , cathepsin L , and/or Bnip3 and inhibited muscle fiber atrophy during cancer cachexia and sepsis . Negative_regulation FBXO32 FOXO6 20228261 2254417 IGF-1 prevents ANG II-induced skeletal muscle atrophy via Akt- and dependent *inhibition* of the ubiquitin ligase [atrogin-1] expression . Negative_regulation FBXO32 FOXO6 22102632 2557430 Expression of DN *inhibited* the increased mRNA levels of [atrogin-1] , MuRF1 , cathepsin L , and/or Bnip3 and inhibited muscle fiber atrophy during cancer cachexia and sepsis . Negative_regulation FBXO32 GHSR 16030067 1473514 Ghrelin receptor agonist *prevents* arthritis induced increase in E3 ubiquitin ligating enzymes MuRF1 and [MAFbx] gene expression in skeletal muscle . Negative_regulation FBXO32 GHSR 18191156 1870215 The increased mRNA level of [Atrogin-1] was significantly *attenuated* by . Negative_regulation FBXO32 GHSR 18191156 1870218 Taken together , directly *attenuates* [Atrogin-1] and MuRF1 mRNA levels through ghrelin receptors in myocytes . Negative_regulation FBXO32 HOXA9 19638619 2138109 DZNep treatment *induced* p16 , p21 , p27 , and [FBXO32] while depleting cyclin E and levels . Negative_regulation FBXO32 HSPB1 19528257 2142372 also *inhibited* the disuse induced increase in MuRF1 and [atrogin-1] transcription by 82 and 40 % , respectively . Negative_regulation FBXO32 HSPB1 19528257 2142384 In conclusion , is a negative regulator of NF-kappaB in skeletal muscle , in vivo , and is *sufficient* to inhibit MuRF1 and [atrogin-1] and attenuate skeletal muscle disuse atrophy . Negative_regulation FBXO32 IGF1 15100091 1288138 rapidly *reduced* [atrogin-1] expression within 1 h by blocking mRNA synthesis without affecting mRNA degradation , whereas IGF-I decreased MuRF1 mRNA slowly . Negative_regulation FBXO32 IGF1 15284206 1302579 We conclude that *inhibits* [atrogin-1/MAFbx] expression and speculate that this effect might contribute to the antiproteolytic action of IGF-I in muscle . Negative_regulation FBXO32 IGF1 17003238 1692543 Whereas the sepsis induced increase in [atrogin-1] expression was completely *prevented* by , the increased MuRF1 was not altered . Negative_regulation FBXO32 IGF1 20228261 2254434 overexpression in skeletal muscle *prevented* ANG II-induced skeletal muscle wasting and the expression of [atrogin-1] , but not MuRF-1 . Negative_regulation FBXO32 IGF1 20399749 2267369 In starved cells , MAFbx-alpha mRNA levels declined in response to amino acid , IGF-I and IGF-II treatments whereas [MAFbx-beta] levels only decreased in *response* to . Negative_regulation FBXO32 IGF1 20519361 2295252 *attenuated* the arthritis induced increase in [atrogin-1] and MuRF1 expression in the gastrocnemius , whereas it did not modify the expression of these genes in the soleus muscle . Negative_regulation FBXO32 IL6 18712412 2028245 [Atrogin-I] gene expression was also *induced* by overexpression of circulating . Negative_regulation FBXO32 IL6 18712412 2028246 These data suggest that high circulating IL-6 levels induce type IIB fiber CSA loss in Apc ( Min/+ ) mice , and circulating is *sufficient* to regulate [Atrogin-I] gene expression in cachectic mice . Negative_regulation FBXO32 INS 23757118 2865757 We report here that acute deficiency in the cardiac muscle of rats induced by streptozotocin *increased* the expression of [atrogin-1] and MuRF1 as well as LC3 and Gabarapl1 , 2 autophagy related genes . Negative_regulation FBXO32 IRS1 19546233 2116775 In turn , the loss of *activated* the FOXO3 dependent induction of [atrogin-1/MAFbx] , a dominant mediator of proteolysis in atrophic muscle . Negative_regulation FBXO32 MLST8 24002653 2856136 To accomplish this goal , in vivo transfection of plasmid DNA was used to create transient transgenic mouse skeletal muscles , and our results show for the first time that Smad3 expression is sufficient to stimulate [atrogin-1] promoter activity , *inhibit* and protein synthesis , and induce muscle fiber atrophy . Negative_regulation FBXO32 MPI 23437325 2744578 Under in vitro conditions of hormonal or fatty acid induced insulin resistance , improves insulin signaling and *reduces* [Atrogin-1] and MuRF-1 protein levels . Negative_regulation FBXO32 MSH2 23515620 2782267 *prevented* arthritis induced increase in gastrocnemius COX-2 , muscle-specific RING-finger protein-1 ( MuRF1 ) , and [atrogin-1] expression , and it increased fast myofiber size . Negative_regulation FBXO32 MSH3 23515620 2782268 *prevented* arthritis induced increase in gastrocnemius COX-2 , muscle-specific RING-finger protein-1 ( MuRF1 ) , and [atrogin-1] expression , and it increased fast myofiber size . Negative_regulation FBXO32 MSH4 23515620 2782269 *prevented* arthritis induced increase in gastrocnemius COX-2 , muscle-specific RING-finger protein-1 ( MuRF1 ) , and [atrogin-1] expression , and it increased fast myofiber size . Negative_regulation FBXO32 MSH5 23515620 2782270 *prevented* arthritis induced increase in gastrocnemius COX-2 , muscle-specific RING-finger protein-1 ( MuRF1 ) , and [atrogin-1] expression , and it increased fast myofiber size . Negative_regulation FBXO32 MSH6 23515620 2782271 *prevented* arthritis induced increase in gastrocnemius COX-2 , muscle-specific RING-finger protein-1 ( MuRF1 ) , and [atrogin-1] expression , and it increased fast myofiber size . Negative_regulation FBXO32 MTOR 19639604 2138134 inhibition *increased* basal [MAFbx] expression and reversed the inhibitory effect of IGF-1 on UL expression . Negative_regulation FBXO32 MTOR 24002653 2856129 Smad3 induces [atrogin-1] , *inhibits* and protein synthesis , and promotes muscle atrophy in vivo . Negative_regulation FBXO32 MTOR 24002653 2856141 To accomplish this goal , in vivo transfection of plasmid DNA was used to create transient transgenic mouse skeletal muscles , and our results show for the first time that Smad3 expression is sufficient to stimulate [atrogin-1] promoter activity , *inhibit* and protein synthesis , and induce muscle fiber atrophy . Negative_regulation FBXO32 PGC 20647557 2322083 Recent studies suggest that muscle atrophy caused by denervation is associated with reduced expression of the nuclear cofactor peroxisome proliferator activated receptor-? coactivator ( PGC ) -1ß and that may be a *repressor* of the [atrogin-1] and MuRF1 genes . Negative_regulation FBXO32 PGC 20647557 2322084 In additional experiments , adenoviral gene transfer of into cultured C2C12 myotubes *resulted* in a dose dependent decrease in [atrogin-1] and MuRF1 mRNA levels . Negative_regulation FBXO32 RPTOR 24002653 2856137 To accomplish this goal , in vivo transfection of plasmid DNA was used to create transient transgenic mouse skeletal muscles , and our results show for the first time that Smad3 expression is sufficient to stimulate [atrogin-1] promoter activity , *inhibit* and protein synthesis , and induce muscle fiber atrophy . Negative_regulation FBXO32 SPARC 23424163 2853746 The loss of not only *upregulates* [atrogin1] expression but also enhances TGFß signaling , which may in turn cause muscle atrophy . Negative_regulation FBXO32 TRIM63 23746953 2819994 To investigate the possible mechanism , MuRF1 and [Fbx32] was subjected to Western blot analysis and expression of was *inhibited* in gastrocnemius muscle . Negative_regulation FBXW8 CCND1 24083669 2863407 Moreover , in HEC108 cells , another endometrial cancer cell line , UA treatment decreased , pERK1/2 , and Cullin1 levels in a dose- and time dependent manner and UA markedly *inhibited* [FBXW8] . Negative_regulation FCER1G EPHB2 19356729 2081125 Exposure to celastrol inhibited the interaction between immunoglobulin Fc epsilon receptor I ( FcepsilonRIgamma ) and and *inhibited* interaction between [FcepsilonRIgamma] and protein kinase C delta (PKCdelta) . Negative_regulation FCER1G PECAM1 20403098 2287890 Whereas the presence or absence of PECAM-1 had no effect on either the rate or extent of platelet adhesion or spreading on laminin , *inhibited* laminin induced phosphorylation of [GPVI-FcR gamma-chain] immunoreceptor tyrosine based activation motifs ( ITAMs ) and activation of its downstream effector , Syk kinase , and suppressed granule secretion . Negative_regulation FCER2 CD14 7902377 234564 Like IL-4 , it *enhanced* the expression of CD11b , CD11c , CD18 , CD29 , CD49e ( VLA-5 ) , class II MHC , CD13 , and [CD23] , whereas it decreased the expression of CD64 , CD32 , CD16 , and in a dose dependent manner . Negative_regulation FCER2 TNF 7547698 327058 IL-4 induced [Fc epsilon RII] expression on the surface of monocytes was *reduced* by as early as 1 day after culture and the effect of TNF-alpha increased with prolonged culture . Negative_regulation FCER2 TNF 7547698 327059 The present analysis was designed to examine whether or not could *suppress* IL-4 induced [Fc epsilon RII] mRNA expression and enhanced IL-4 induced sFc epsilon RII release . Negative_regulation FCER2 TNF 7547698 327063 When the cells were cultured with TNF-alpha for more than 24 h , however , *down-regulated* IL-4 induced [Fc epsilon RII] mRNA levels . Negative_regulation FCER2 TNF 8478029 218653 Interestingly , on human monocytes weakly *reduced* the basal level of [Fc epsilon RII] , and markedly diminished the IL-4 induced Fc epsilon RII expression . Negative_regulation FCER2 TNF 9122614 423991 The expression of GM-CSF- , IL-3- or M-CSF induced [Fc epsilon RII] on the surface of monocytes was *reduced* by . Negative_regulation FCER2 TNF 9122614 423995 These results suggest that *dependent* reduction of GM-CSF- , IL-3- or M-CSF induced [Fc epsilon RII] expression on the surface of monocytes resulted , at least in part , from the suppression of Fc epsilon RII mRNA and the enhancement of sFc epsilon RII release . Negative_regulation FCER2 TNF 9298175 453279 N-acetylcysteine attenuates *dependent* reduction of IL-4 induced [Fc epsilon RII] expression in human monocytes . Negative_regulation FCER2 TNF 9298175 453282 We have previously shown that *reduces* interleukin-4 (IL-4) induced [Fc epsilon RII] expression in human monocytes . Negative_regulation FCER2 TNF 9298175 453284 Therefore , we hypothesized that *dependent* reduction of IL-4 induced [Fc epsilon RII] expression in monocytes might be mediated through the ROIs activated mechanism . Negative_regulation FCER2 TNF 9298175 453287 In the present study , to test our hypothesis , we examined the effect of NAC on *dependent* reduction of IL-4 induced [Fc epsilon RII] expression in human monocytes . Negative_regulation FCER2 TNF 9298175 453291 NAC attenuated *dependent* reduction of IL-4 induced [Fc epsilon RII] expression by attenuating TNF-alpha dependent reduction of Fc epsilon RII mRNA expression . Negative_regulation FCER2 TNF 9298175 453295 These results indicate that an ROIs activated and antioxidant-sensitive mechanism might be involved in *dependent* reduction of IL-4 induced [Fc epsilon RII] expression in monocytes . Negative_regulation FCGR2A RNASE1 16729300 1570499 In contrast , U1 snRNP combined with SLE-IgG induced IFNalpha production only in NIPCs/pDC , and this response was decreased by treatment or *inhibition* of the [Fc gammaRIIa] , the endocytosis pathways , or the TLRs . Negative_regulation FCGR2A RNASE7 16729300 1570507 In contrast , U1 snRNP combined with SLE-IgG induced IFNalpha production only in NIPCs/pDC , and this response was decreased by treatment or *inhibition* of the [Fc gammaRIIa] , the endocytosis pathways , or the TLRs . Negative_regulation FCGR2B IL1B 9142862 428542 During reoxygenation , both whole blood PMN phagocytosis and bactericidal activity were reduced in the *presence* of IL-8 , TNF-alpha , or , and in subsets of PMN with reduced phagocytosis H/R reduced CD64 , [CD32w] , CD16 , CD35 , and CD11b/CD18 expression in the presence of each cytokine . Negative_regulation FCGR2B TNF 15593228 1346335 *down-regulated* expression of [FcgammaRIIb] and the activating FcgammaR , whereas IL-10 up-regulated expression of monocytic FcgammaRIIb and all activating FcgammaR . Negative_regulation FCGR2B TNF 17082598 1643227 The [FcgammaRIIB] blockade inhibits GXM induced IL-10 production and *induces* secretion . Negative_regulation FCGR2B TNF 18328152 1881369 *down-regulated* all activating FcgammaRs , mainly FcgammaRIIa and IIIa , but also the inhibitory [FcgammaRIIb] . Negative_regulation FCGR2B TNF 9142862 428541 During reoxygenation , both whole blood PMN phagocytosis and bactericidal activity were reduced in the presence of IL-8 , , or IL-1beta , and in subsets of PMN with reduced phagocytosis H/R *reduced* CD64 , [CD32w] , CD16 , CD35 , and CD11b/CD18 expression in the presence of each cytokine . Negative_regulation FCGR3A MUC16 16126266 1482303 did , however , *induce* major downregulation of [CD16] and minor decrease in expression of CD94/NKG2A . Negative_regulation FCGR3A SELL 8609224 352766 In the absence of serum , galactoxylomannan and mannoprotein did not affect L-selectin , TNF receptor , CD15 , CD11b , or [CD16] on neutrophils but did *induce* loss of in the presence of serum . Negative_regulation FCGR3B TNF 20102624 2258734 Intriguingly , *blocked* [CD16] expression on a subset of CD14+ monocytes . Negative_regulation FER EPHB2 21518868 2428887 EGF activates NF-?B and *stimulates* phosphorylation of [FER] , EGF receptor (EGFR) , and ERK p42/p44 , and decreased expression of FER or inhibition of phosphorylation inhibits the EGF induced activation of NF-?B . Negative_regulation FGA ITGB2 10997789 734096 [Fibrinogen] binding on Cytochalasin-B activated monocytes was *reduced* to 79.8+/-6.0 % in the presence of ( 20 microg/ml ; Negative_regulation FGA TNF 1707930 155086 [Fibrinogen] was induced only by IL-6 and this induction was *inhibited* by IL-1 alpha , or transforming growth factor beta 1 . Negative_regulation FGB F3 2207329 142560 also *caused* a rapid decrease of systemic [fibrinogen] that was accompanied by a lengthening of the activated partial thromboplastin time and prothrombin time . Negative_regulation FGB IL1B 11071643 748130 *inhibits* interleukin 6-mediated rat gamma [fibrinogen] gene expression . Negative_regulation FGB IL1B 12202007 983012 ( 10 ng/mL ) *inhibited* albumin ( -90 % ) , urea ( -40 to 50 % ) , and IL-6 stimulated [fibrinogen] ( -90 % ) secretion . Negative_regulation FGB PECAM1 24969778 2952459 Here , we show that the activation of *inhibits* [fibrinogen] binding to integrin aIIbß3 and P-selectin surface expression in response to thrombin ( 0.1-3 U/mL ) but not thrombin receptor activating peptides SFLLRN ( 3×10 ( -7 ) -1×10 ( -5 ) mol/L ) and GYPGQV ( 3×10 ( -6 ) -1×10 ( -4 ) mol/L ) . Negative_regulation FGB PLAT 11775254 766381 The plasma level of platelet alpha-granular membrane protein-140 , soluble fibrinomonomer complex , thrombomodulin , and D-dimer significantly *increased* , [fibrinogen] , antigen level of protein C , plasminogen , alpha 2-plasminogen inhibitor and plasminogen activator inhibitor decreased at diagnosis , were restored to normal after complete remission but protein C activity and protein S remained elevated in ATRA group . Negative_regulation FGB PLAT 16977483 1633512 Zymosan administration caused MOFS by affecting the coagulation cascade , as shown by a significant increase in plasma levels of [fibrinogen] , , *inhibitor* of tissue plasminogen activator of type 1 , and plasma levels of fibrin degradation products vs. control rats . Negative_regulation FGB TF 19320475 2073793 In the *presence* of both and IgG , curcumin continues to undergo rapid hydrolysis but this reaction is suppressed by the presence of either HSA or [fibrinogen] with an impressive yield of approximately 95 % . Negative_regulation FGB TNF 2201637 140474 Tumor necrosis factor (TNF) is induced in mice by Candida albicans : *role* of in [fibrinogen] increase . Negative_regulation FGB TNF 7557864 327866 In contrast to Il-6 and Il-1 alpha , *reduced* the production of [fibrinogen] and ceruloplasmin but stimulated the production of ferritin . Negative_regulation FGD3 BTRC 18363964 1887898 Here we show that [FGD3] , which was identified as a homologue of FGD1 but has been poorly characterized , has conserved the same motif and is *down-regulated* similarly by ( FWD1/beta-TrCP ) . Negative_regulation FGD3 CUL1 18363964 1887899 Here we show that [FGD3] , which was identified as a homologue of FGD1 but has been poorly characterized , has conserved the same motif and is *down-regulated* similarly by ( FWD1/beta-TrCP ) . Negative_regulation FGD3 SKP1 18363964 1887897 Here we show that [FGD3] , which was identified as a homologue of FGD1 but has been poorly characterized , has conserved the same motif and is *down-regulated* similarly by ( FWD1/beta-TrCP ) . Negative_regulation FGF1 FGFBP1 1885605 165719 In addition was found to *inhibit* the biological activities of both [HBGF-1] and HBGF-2 . Negative_regulation FGF1 MAP2K6 15766753 1383711 RPE transdifferentiation under the organotypic culture condition was abolished by a ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an [FGF] receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation FGF1 TF 6725271 38571 Insulin , liposomes , and [fibroblast growth factor] were *required* for optimum growth in the serum-free medium , but removal of , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation FGF10 MAP2K6 15766753 1383718 RPE transdifferentiation under the organotypic culture condition was abolished by a ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an [FGF] receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation FGF10 TF 6725271 38572 Insulin , liposomes , and [fibroblast growth factor] were *required* for optimum growth in the serum-free medium , but removal of , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation FGF11 MAP2K6 15766753 1383725 RPE transdifferentiation under the organotypic culture condition was abolished by a ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an [FGF] receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation FGF11 TF 6725271 38573 Insulin , liposomes , and [fibroblast growth factor] were *required* for optimum growth in the serum-free medium , but removal of , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation FGF12 MAP2K6 15766753 1383732 RPE transdifferentiation under the organotypic culture condition was abolished by a ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an [FGF] receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation FGF12 TF 6725271 38574 Insulin , liposomes , and [fibroblast growth factor] were *required* for optimum growth in the serum-free medium , but removal of , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation FGF13 MAP2K6 15766753 1383739 RPE transdifferentiation under the organotypic culture condition was abolished by a ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an [FGF] receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation FGF13 TF 6725271 38575 Insulin , liposomes , and [fibroblast growth factor] were *required* for optimum growth in the serum-free medium , but removal of , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation FGF14 MAP2K6 15766753 1383746 RPE transdifferentiation under the organotypic culture condition was abolished by a ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an [FGF] receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation FGF14 TF 6725271 38576 Insulin , liposomes , and [fibroblast growth factor] were *required* for optimum growth in the serum-free medium , but removal of , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation FGF16 MAP2K6 15766753 1383753 RPE transdifferentiation under the organotypic culture condition was abolished by a ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an [FGF] receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation FGF16 TF 6725271 38577 Insulin , liposomes , and [fibroblast growth factor] were *required* for optimum growth in the serum-free medium , but removal of , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation FGF17 MAP2K6 15766753 1383760 RPE transdifferentiation under the organotypic culture condition was abolished by a ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an [FGF] receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation FGF17 TF 6725271 38578 Insulin , liposomes , and [fibroblast growth factor] were *required* for optimum growth in the serum-free medium , but removal of , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation FGF18 MAP2K6 15766753 1383767 RPE transdifferentiation under the organotypic culture condition was abolished by a ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an [FGF] receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation FGF18 TF 6725271 38579 Insulin , liposomes , and [fibroblast growth factor] were *required* for optimum growth in the serum-free medium , but removal of , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation FGF19 EPHB2 19233843 2054720 [FGF-19] inhibition of lipogenic enzyme expression was not *mediated* by alterations in the activity of the insulin signal transduction pathway or changes in the activity of , p38 MAPK , and AMP activated protein kinase (AMPK) . Negative_regulation FGF19 MAP2K6 15766753 1383774 RPE transdifferentiation under the organotypic culture condition was abolished by a ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an [FGF] receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation FGF19 TF 6725271 38580 Insulin , liposomes , and [fibroblast growth factor] were *required* for optimum growth in the serum-free medium , but removal of , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation FGF2 EPHB2 15247255 1295852 Moreover , using pharmacological inhibitors we demonstrate the critical *role* of but not JNK in [FGF-2-inducible] PDGF-C expression . Negative_regulation FGF2 EPHB2 18656513 1972789 Relative *role* of upstream regulators of Akt , and CREB in NCAM- and [FGF2] mediated signalling . Negative_regulation FGF2 EPHB2 24445144 2942453 Moreover , knockdown of brachyury by small hairpin RNA reduced [FGF2] secretion , *inhibited* phosphorylation and blocked the effects of FGF2 on cell growth , apoptosis and EMT . Negative_regulation FGF2 FGFBP1 17553847 1773828 Moreover , using PC12 cells as a neuronal model , we observed that exogenous *increased* the capacity of [FGF2] to stimulate neurite outgrowth and to increase cell survival . Negative_regulation FGF2 FGFBP1 1885605 165720 In addition was found to *inhibit* the biological activities of both HBGF-1 and [HBGF-2] . Negative_regulation FGF2 IL1B 19014534 1998277 However , exogenous *reduced* the [FGF-2] levels , strongly elevated the FGF-2 binding protein PTX3 , and prevented the reduction in the number of pneumocytes induced by silica . Negative_regulation FGF2 MAP2K6 15766753 1383781 RPE transdifferentiation under the organotypic culture condition was abolished by a ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an [FGF] receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation FGF2 MAP2K6 24445144 2942463 Moreover , knockdown of brachyury by small hairpin RNA reduced [FGF2] secretion , *inhibited* phosphorylation and blocked the effects of FGF2 on cell growth , apoptosis and EMT . Negative_regulation FGF2 TF 6725271 38581 Insulin , liposomes , and [fibroblast growth factor] were *required* for optimum growth in the serum-free medium , but removal of , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation FGF2 TNF 22179526 2575011 inhibition in diabetic animals also reduced apoptosis , increased proliferation of bone lining cells , and *increased* mRNA levels of [FGF-2] , TGFß-1 , BMP-2 , and BMP-6 . Negative_regulation FGF20 MAP2K6 15766753 1383788 RPE transdifferentiation under the organotypic culture condition was abolished by a ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an [FGF] receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation FGF20 TF 6725271 38582 Insulin , liposomes , and [fibroblast growth factor] were *required* for optimum growth in the serum-free medium , but removal of , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation FGF21 MAP2K6 15766753 1383795 RPE transdifferentiation under the organotypic culture condition was abolished by a ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an [FGF] receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation FGF21 TF 6725271 38583 Insulin , liposomes , and [fibroblast growth factor] were *required* for optimum growth in the serum-free medium , but removal of , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation FGF22 MAP2K6 15766753 1383802 RPE transdifferentiation under the organotypic culture condition was abolished by a ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an [FGF] receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation FGF22 TF 6725271 38584 Insulin , liposomes , and [fibroblast growth factor] were *required* for optimum growth in the serum-free medium , but removal of , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation FGF23 MAP2K6 15766753 1383809 RPE transdifferentiation under the organotypic culture condition was abolished by a ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an [FGF] receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation FGF23 TF 6725271 38585 Insulin , liposomes , and [fibroblast growth factor] were *required* for optimum growth in the serum-free medium , but removal of , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation FGF3 MAP2K6 15766753 1383816 RPE transdifferentiation under the organotypic culture condition was abolished by a ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an [FGF] receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation FGF3 TF 6725271 38586 Insulin , liposomes , and [fibroblast growth factor] were *required* for optimum growth in the serum-free medium , but removal of , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation FGF4 MAP2K6 15766753 1383823 RPE transdifferentiation under the organotypic culture condition was abolished by a ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an [FGF] receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation FGF4 TF 6725271 38587 Insulin , liposomes , and [fibroblast growth factor] were *required* for optimum growth in the serum-free medium , but removal of , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation FGF5 MAP2K6 15766753 1383830 RPE transdifferentiation under the organotypic culture condition was abolished by a ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an [FGF] receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation FGF5 TF 6725271 38588 Insulin , liposomes , and [fibroblast growth factor] were *required* for optimum growth in the serum-free medium , but removal of , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation FGF6 MAP2K6 15766753 1383837 RPE transdifferentiation under the organotypic culture condition was abolished by a ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an [FGF] receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation FGF6 TF 6725271 38589 Insulin , liposomes , and [fibroblast growth factor] were *required* for optimum growth in the serum-free medium , but removal of , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation FGF7 MAP2K6 15766753 1383844 RPE transdifferentiation under the organotypic culture condition was abolished by a ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an [FGF] receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation FGF7 TF 6725271 38590 Insulin , liposomes , and [fibroblast growth factor] were *required* for optimum growth in the serum-free medium , but removal of , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation FGF8 MAP2K6 15766753 1383851 RPE transdifferentiation under the organotypic culture condition was abolished by a ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an [FGF] receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation FGF8 TF 6725271 38591 Insulin , liposomes , and [fibroblast growth factor] were *required* for optimum growth in the serum-free medium , but removal of , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation FGF9 MAP2K6 15766753 1383858 RPE transdifferentiation under the organotypic culture condition was abolished by a ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an [FGF] receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation FGF9 TF 6725271 38592 Insulin , liposomes , and [fibroblast growth factor] were *required* for optimum growth in the serum-free medium , but removal of , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation FGFR1 CCND1 18665077 1943051 Inhibition of , known to be induced by insulinlike growth factor I , epidermal growth factor , and FGF2 , *resulted* in an inhibition of [FGFR1-IIIc] expression , whereas FGFR1-IIIb expression was enhanced . Negative_regulation FGFR1 EPHB2 17255109 1710352 Direct binding of PP2A to Sprouty2 and phosphorylation changes are a prerequisite for *inhibition* downstream of [fibroblast growth factor receptor] stimulation . Negative_regulation FGFR1 EPHB2 20434485 2274737 The results demonstrate that taspine can down-regulate phosphorylation of FGFR1 and , and *inhibit* [Hek293/FGFR1] and MCF-7 cell proliferation . Negative_regulation FGFR1 EPHB2 23059005 2716694 Moreover , we showed that Ru-SeNPs *inhibited* the activations of [FGFR1] and its downstream protein kinases , such and AKT . Negative_regulation FGFR2 EPHB2 17255109 1710353 Direct binding of PP2A to Sprouty2 and phosphorylation changes are a prerequisite for *inhibition* downstream of [fibroblast growth factor receptor] stimulation . Negative_regulation FGFR2 MAP2K6 21152424 2356391 Moreover , inhibitors of c-Src and *stimulated* [fgfr2-luc] activity to a similar degree as gefitinib , suggesting that these pathways may mediate EGFR dependent repression of FGFR2 and FGFR3 . Negative_regulation FGFR2 TP63 23545251 2763008 In addition , [KGFR] *induced* a ligand dependent decrease of through a miR-203 independent mechanism and this effect was blocked by inhibition of the PI3K/Akt signaling , which is the main pathway involved in KGFR dependent keratinocyte differentiation , suggesting that alterations of the KGFR/p63 crosstalk are responsible for the impairment of keratinocyte differentiation induced by 16E5 and that the opposite tumor-suppressive action of KGFR and oncogenic role of E5 might both involve p63 . Negative_regulation FGFR3 EPHB2 17255109 1710354 Direct binding of PP2A to Sprouty2 and phosphorylation changes are a prerequisite for *inhibition* downstream of [fibroblast growth factor receptor] stimulation . Negative_regulation FGFR3 IL1B 15550558 1380566 Because may *mediate* esophagitis associated reduction in [ACh] release in esophagus , we examined whether IL-1beta may also play a role in esophagitis induced reduction of LES tone . Negative_regulation FGFR3 IL1B 8949656 400655 Pretreatment with cycloheximide blocked *induced* inhibition of [ACh] stimulated jejunal contraction , suggesting that a newly synthesised protein was involved in the effect . Negative_regulation FGFR3 TNF 12069938 955675 *caused* significant inhibition of [ACh-] and bradykinin induced vascular relaxation and nitrite/nitrate production that were more prominent in pregnant than virgin rats . Negative_regulation FGFR3 TNF 14530204 1152009 Furthermore , *inhibited* the [ACh] forearm blood flow response ( P < 0.001 ) , and this inhibition was larger during insulin infusion ( P=0.01 ) but not further increased by NG-monomethyl-L-arginine acetate ( P=0.2 ) . Negative_regulation FGFR4 EPHB2 17255109 1710355 Direct binding of PP2A to Sprouty2 and phosphorylation changes are a prerequisite for *inhibition* downstream of [fibroblast growth factor receptor] stimulation . Negative_regulation FGG ITGB2 10997789 734097 [Fibrinogen] binding on Cytochalasin-B activated monocytes was reduced to 79.8+/-6.0 % in the *presence* of ( 20 microg/ml ; Negative_regulation FGG TNF 1707930 155088 [Fibrinogen] was induced only by IL-6 and this induction was *inhibited* by IL-1 alpha , or transforming growth factor beta 1 . Negative_regulation FHL1 ADCY10 16407297 1533658 Overexpression of [FHL1] in differentiating C2C12 cells *induced* `` '' myotube formation ( myosac ) , associated with impaired Z-line and myosin thick filament assembly . Negative_regulation FHL1 TLX1 18073142 1861924 Here , we provide an explanation for these findings by demonstrating that the induction of [FHL1] , but not ALDH1A1 , *requires* a high level of expression in NIH 3T3 cells . Negative_regulation FHL1 TMEM173 19840196 2374839 Physical interaction of FHL1 and *required* for [FHL1] repression of oestrogen-responsive gene transcription . Negative_regulation FIGF IL1B 17929249 1866353 Concurrent inhibition of ERK1/2 or JNKs and PKCalpha/beta1 resulted in a synergistic inhibition of *induced* decreases in [VEGF-D] . Negative_regulation FIGF TNF 21483160 2434561 In vitro , significantly *down-regulated* [VEGF-D] mRNA expression in cultured fibroblasts ( P = 0.004 ) . Negative_regulation FKBP1A TNF 24053175 2902431 Asthmatic serum , IL-5 , IL-13 , and enhance the calcium response of BSMCs to contractile agonists and *cause* dissociation of FKBP12 .6 from RyR2 and a decrease in [FKBP12] .6 gene expression in BSMCs in culture and in ovalbumin ( OVA ) -sensitized and -challenged rats . Negative_regulation FKBP8 S100B 23522085 2803983 In vitro binding studies showed that S100A1 , S100A2 , S100A6 , and S100P directly interacted with FKBP8/FKBP38 in a Ca ( 2+ ) -dependent manner and *inhibited* the FKBP8/FKBP38-Hsp90 and [FKBP8/FKBP38-NS5A] interactions . Negative_regulation FKBP8 S100B 24295050 2899000 In vitro binding studies demonstrated that S100A1 , S100A2 , S100A6 , and S100P specifically interact with FKBP38 and *inhibit* the interaction of [FKBP38] with Bcl-2 and Hsp90 . Negative_regulation FLG C19orf10 22433370 2573346 Furthermore , we show that can *inhibit* [filaggrin] synthesis in keratinocytes . Negative_regulation FLG HRAS 17045653 1666540 In the present study , we investigated the *role* of in [FLG-] and LPS mediated signaling in ERK activation in chicken heterophils . Negative_regulation FLG IL13 18385759 1944168 Importantly , transduction of p21-recombinant protein into keratinocytes prevented *mediated* inhibition of [FLG] and HBD-3 expression . Negative_regulation FLG IL4 18385759 1944169 Importantly , transduction of p21-recombinant protein into keratinocytes prevented mediated *inhibition* of [FLG] and HBD-3 expression . Negative_regulation FLG KRAS 17045653 1666541 In the present study , we investigated the *role* of in [FLG-] and LPS mediated signaling in ERK activation in chicken heterophils . Negative_regulation FLG NRAS 17045653 1666542 In the present study , we investigated the *role* of in [FLG-] and LPS mediated signaling in ERK activation in chicken heterophils . Negative_regulation FLG SFTPC 20230798 2244147 In this study , we demonstrated that significantly *reduces* [filaggrin] gene transcription , implying that SPC plays a pivotal role in impairment of the epidermal permeability barrier in atopic dermatitis lesional skin . Negative_regulation FLG SFTPC 20230798 2244149 We propose that the increase in SPC levels further aggravates dermatological symptoms of atopic dermatitis through *induced* down-regulation of [filaggrin] in NHK . Negative_regulation FLG SIK1 9405638 470068 Overexpression of in EMK cells *results* in increased expression of [filaggrin] during differentiation , supporting a role for Sik in differentiation . Negative_regulation FLG SIK2 9405638 470069 Overexpression of in EMK cells *results* in increased expression of [filaggrin] during differentiation , supporting a role for Sik in differentiation . Negative_regulation FLG SIK3 9405638 470070 Overexpression of in EMK cells *results* in increased expression of [filaggrin] during differentiation , supporting a role for Sik in differentiation . Negative_regulation FLG STIP1 21256618 2392580 Overexpression of using a lentiviral vector *up-regulated* [FLG] and LOR expression during keratinocyte differentiation . Negative_regulation FLG TIMP1 19651791 2118973 It was found that several critical genes expressed by the keratinocytes including NO synthase ( NOS1 ) , superoxide dismutase 1 (SOD1) , transglutaminase 1 and 3 ( TGM1 and TGM3 ) , metallopeptidase *inhibitor* 1 ( ) , and [filaggrin (FLG)] were clearly influenced by the damaged nerve cells . Negative_regulation FLT1 MAP2K6 18056475 1833686 inhibition also *resulted* in a rapid decline in the [ ( 18 ) F ] [FLT] signal in V600E BRAF mutant SKMEL-28 xenografts but not in BRAF wild-type BT-474 xenografts . Negative_regulation FLT4 TNF 15555625 1340071 significantly *reduced* protein levels of VEGFR-2 , [VEGFR-3] , and NRP-1 by 59 , 35 , and 22 % , respectively . Negative_regulation FLVCR2 TNF 10734122 678732 Immunoblotting revealed that *inhibition* of [CCT] activity was associated with a uniform decrease in the mass of CCTalpha in total cell lysates , cytosolic , microsomal , and nuclear subfractions of MLE cells . Negative_regulation FMR1 TNF 12921647 1130993 [POF] *induced* a dose dependent suppression of the spontaneous release from AM in sarcoidosis ( P < 0.001 ) , while the spontaneous release of other cytokines was unaffected by POF at all tested concentrations , but a trend for the inhibition of IL-10 production was found ( P = 0.092 ) . Negative_regulation FMR1 TNF 14555589 1153140 The results showed that [POF] *induced* a dose dependent suppression of the spontaneous release from AMs in sarcoidosis ( p < 0.001 ) , and that the spontaneous release of the other cytokines was unaffected by POF at all tested concentrations , but a trend for the inhibition of IL-10 production was found ( p = 0.092 ) . Negative_regulation FMR1 TNF 15061967 1230591 [POF] *induced* a dose dependent suppression of spontaneous and IL-10 release from AM in EAA ( P < 0.001 and P < 0.05 ) . Negative_regulation FMR1 TNF 9927365 588556 [POF] *induced* a dose dependent suppression of the LPS stimulated production which was not different for PBM and AM , respectively . Negative_regulation FN1 ANGPT1 17085463 1685075 also *reduced* renal tissue levels of transforming growth factor-beta1 ( TGF-beta1 ) , alpha-smooth muscle actin , [fibronectin] , as well as Smad 2/3 expression , but increased Smad 7 expression . Negative_regulation FN1 CTGF 11390712 822895 Moreover , significantly *reduced* TGFbeta induced increase in [fibronectin] . Negative_regulation FN1 CTGF 11934704 927853 *Role* of in [fibronectin] expression and tubulointerstitial fibrosis . Negative_regulation FN1 CTGF 16527597 1536195 *Role* of in [fibronectin] synthesis in cultured human prostate stromal cells . Negative_regulation FN1 CTGF 19541844 2231906 Furthermore , overexpression of *increased* integrin linked kinase expression , activated its downstream signaling target , Akt , as well as increased mRNA expression of [fibronectin] . Negative_regulation FN1 EPHB2 15265761 1302239 In conclusion , the results indicate that GnRHa and TGF-beta signaling through *results* in differential regulation of [fibronectin] expression in endometrial cells , a molecular mechanism where short- and long-term GnRHa therapy and locally expressed TGF-beta could influence embryo implantation and endometriosis implants , respectively . Negative_regulation FN1 EPHB2 17030187 1630586 Blocking MLC or phosphorylation *inhibited* the motogenic effect of strain on [fibronectin] . Negative_regulation FN1 ITGB2 1358490 200374 MoAb completely *inhibited* the binding of TNF stimulated PMN to [fibronectin] and partially inhibited the binding to laminin . Negative_regulation FN1 MMP7 19022775 2029261 RECK is cleaved by MMP-2 and and competitively *inhibits* MMP-7 catalyzed cleavage of [fibronectin] . Negative_regulation FN1 S1PR3 22406263 2577319 In the current study , we explored *role* of in [fibronectin] expression and underlying molecular mechanism . Negative_regulation FN1 TNF 8466280 216021 *inhibited* collagen production and mRNA levels of collagens I and III and of [fibronectin] , and stimulated collagenase activity and collagenase mRNA levels in SSs fibroblasts . Negative_regulation FOLH1 MIP 21680691 2451360 <123I-MIP-1072> , a small-molecule *inhibitor* of [prostate-specific membrane antigen] , is effective at monitoring tumor response to taxane therapy . Negative_regulation FOLR1 ADCY1 8001792 283836 Glucose repression of [fbp1] transcription of Schizosaccharomyces pombe is partially *regulated* by activation by a G protein alpha subunit encoded by gpa2 ( git8 ) . Negative_regulation FOLR1 ADCY10 8001792 283835 Glucose repression of [fbp1] transcription of Schizosaccharomyces pombe is partially *regulated* by activation by a G protein alpha subunit encoded by gpa2 ( git8 ) . Negative_regulation FOLR1 ADCY2 8001792 283837 Glucose repression of [fbp1] transcription of Schizosaccharomyces pombe is partially *regulated* by activation by a G protein alpha subunit encoded by gpa2 ( git8 ) . Negative_regulation FOLR1 ADCY3 8001792 283838 Glucose repression of [fbp1] transcription of Schizosaccharomyces pombe is partially *regulated* by activation by a G protein alpha subunit encoded by gpa2 ( git8 ) . Negative_regulation FOLR1 ADCY4 8001792 283839 Glucose repression of [fbp1] transcription of Schizosaccharomyces pombe is partially *regulated* by activation by a G protein alpha subunit encoded by gpa2 ( git8 ) . Negative_regulation FOLR1 ADCY5 8001792 283840 Glucose repression of [fbp1] transcription of Schizosaccharomyces pombe is partially *regulated* by activation by a G protein alpha subunit encoded by gpa2 ( git8 ) . Negative_regulation FOLR1 ADCY6 8001792 283841 Glucose repression of [fbp1] transcription of Schizosaccharomyces pombe is partially *regulated* by activation by a G protein alpha subunit encoded by gpa2 ( git8 ) . Negative_regulation FOLR1 ADCY7 8001792 283842 Glucose repression of [fbp1] transcription of Schizosaccharomyces pombe is partially *regulated* by activation by a G protein alpha subunit encoded by gpa2 ( git8 ) . Negative_regulation FOLR1 ADCY8 8001792 283843 Glucose repression of [fbp1] transcription of Schizosaccharomyces pombe is partially *regulated* by activation by a G protein alpha subunit encoded by gpa2 ( git8 ) . Negative_regulation FOLR1 ADCY9 8001792 283844 Glucose repression of [fbp1] transcription of Schizosaccharomyces pombe is partially *regulated* by activation by a G protein alpha subunit encoded by gpa2 ( git8 ) . Negative_regulation FOLR1 TYR 3080348 56521 By correlating the size of the peptide fragments released by these enzymes with the known sequence of aldolase , evidence has been provided that cleavage of His-359 and/or *lead* to the loss of [FBP] activity , while further cleavage of up to six amino acids begin to affect activity against F1P , as well . Negative_regulation FOS EPHB2 15930517 1433900 Moreover , inhibition of and JNK by EPA *resulted* in the decrease of [c-Fos] expression and c-Jun phosphorylation/expression induced by UV , respectively , which led to the inhibition of UV-induced activator protein-1 DNA binding activity . Negative_regulation FOS EPHB2 16413539 1514347 Moreover , inhibitions of and JNK by 2',4',7-THF *resulted* in the decrease of [c-Fos] expression and c-Jun phosphorylation/expression induced by UV , respectively , which led to the inhibition of UV-induced AP-1 DNA binding activity . Negative_regulation FOS EPHB2 17941091 1866507 p38 inhibitor , SB203580 or JNK inhibitor , SP600125 but not inhibitor , PD98059 *attenuated* the US-induced MMP-13 , [c-Fos] , and c-Jun expression ; Negative_regulation FOS EPHB2 19627209 2112765 Moreover , inhibition of phosphorylated , JNK , and p38 by K. pandurata extract *resulted* in decreased [c-Fos] expression and c-Jun phosphorylation induced by UV light . Negative_regulation FOS IL1B 17496810 1739502 This study investigated the *role* of in the expression of [Fos] , a marker of neuronal activation , and hyperalgesia caused by injecting complete Freund 's adjuvant into one hind paw of the rat . Negative_regulation FOS MAP2K6 21163924 2390746 Reexpression of MAF rescued cells from death induced by MMSET depletion , *inhibition* , or [FOS] inactivation . Negative_regulation FOS MSX1 23867769 2835245 TBZ ( 2.0mg/kg ) significantly increased the number of c-Fos positive cells in the VLS , which is indicative of reduced DA D2 receptor transmission , and 10.0mg/kg significantly *attenuated* the TBZ induced [c-Fos] expression . Negative_regulation FOS TNF 16098952 1448199 These asymmetric *induced* increases in the number of [Fos-] and IL1beta-IR cells were evident along the outside surface of the cortex ( mainly layers II and III ) in a restricted rostral to caudal zone . Negative_regulation FOXA1 ELF3 23266329 2745809 KLF5 directly inhibited activity of the [FoxA1] promoter , and in turn FOXA1 *inhibited* gene expression in vitro , linking the observed loss of Elf3 with the persistent expression of FoxA1 observed in Klf5-deficient mice . Negative_regulation FOXA1 ELF5 23300383 2712260 *suppressed* ER and [FOXA1] expression and broadly suppressed ER-driven patterns of gene expression including sets of genes distinguishing the luminal molecular subtype . Negative_regulation FOXA1 FOXA2 8553537 339974 Moreover , could switch on the activity of ENII in HeLa cells and the activity of ENII could be *suppressed* by antisense [HNF3 alpha] and antisense HNF3 beta mRNA in HepG2 cells . Negative_regulation FOXA1 HEXIM1 24844355 2951067 Novel insight into the mechanistic basis for HEXIM1 inhibition of AR activity is provided by the present studies showing that induces expression of the histone demethylase KDM5B ( lysine-specific demethylase 5B ) and inhibits histone methylation , *resulting* in the inhibition of [FOXA1] ( forkhead box A1 ) licensing activity . Negative_regulation FOXA1 IL4 19076932 2024221 INF-gamma increased , whereas *inhibited* [hepatocyte nuclear factor-3alpha] expression . Negative_regulation FOXA1 MYLIP 24486549 2918553 Thus , our results suggest that the downregulation of expression could *lead* to [FoxA1] overexpression in ALI . Negative_regulation FOXA1 NR0B2 15358835 1334164 Orphan nuclear receptor *represses* hepatocyte nuclear factor [3/Foxa] transactivation via inhibition of its DNA binding . Negative_regulation FOXA1 ONECUT1 15562441 1343455 Transcription factor *inhibits* the stimulation of the [HNF-3alpha/Foxa1] gene by TGF-beta in mouse liver . Negative_regulation FOXA1 ONECUT1 15562441 1343458 We observed that Foxa1 expression was upregulated in the liver of Hnf6 ( -/- ) mouse embryos and in bipotential mouse embryonic liver ( BMEL ) cell lines derived from embryonic Hnf6 ( -/- ) liver , suggesting that *inhibits* the expression of [Foxa1] . Negative_regulation FOXA1 ONECUT1 15562441 1343459 Because no evidence for a direct *repression* of [Foxa1] by was found , we postulated the existence of an indirect mechanism . Negative_regulation FOXA1 ONECUT1 15562441 1343460 We further conclude that *inhibits* [Foxa1] by inhibiting the activity of the TGF-beta signaling pathway . Negative_regulation FOXA1 POU5F1 11891324 922762 Although FoxD3 activated the FoxA1 and FoxA2 promoters , *inhibited* FoxD3 activation of the [FoxA1] and FoxA2 endodermal promoters . Negative_regulation FOXA1 SMAD3 18003659 1851516 *prevents* binding of NKX2.1 and [FOXA1] to the SpB promoter through its MH1 and MH2 domains . Negative_regulation FOXA2 ALOX5 23822876 2870690 [Foxa2] expression *inhibited* 15-lipoxygenase ( Alox15 ) and increased transcription , each encoding key lipoxygenases associated with asthma . Negative_regulation FOXA2 FOXA1 8553537 339975 Moreover , [HNF3 beta] could switch on the activity of ENII in HeLa cells and the activity of ENII could be *suppressed* by antisense and antisense HNF3 beta mRNA in HepG2 cells . Negative_regulation FOXA2 FOXO1 16644672 1553106 Gene expression and chromatin immunoprecipitation assays demonstrated that GLP-1 increases pancreatic and duodenal homeobox gene-1 and [Foxa2] expression and *inhibits* binding to both promoters . Negative_regulation FOXE1 TNF 10465294 640560 and interferon-gamma *suppress* both gene expression and deoxyribonucleic acid binding of [TTF-2] in FRTL-5 cells . Negative_regulation FOXE1 TNF 10465294 640564 and IFN-gamma simultaneously *caused* a marked decrease in [TTF-2] mRNA levels ( 13+/-2 % ) . Negative_regulation FOXL2 CLU 23051594 2702839 [FOXL2] binds and suppresses the PTTG promoter , and also *suppresses* PTTG expression , thus neutralizing protumorigenic PTTG gonadotroph tumor cell properties . Negative_regulation FOXM1 CCND1 16913845 1602110 The proliferation stimulating transactivator [FOXM1c] ( MPP2 ) is *repressed* by RB and activated by and therefore behaves like E2F . Negative_regulation FOXM1 CCND1 18206647 1870572 In contrast , we now demonstrate that this LXL-motif is not required for the activation of FOXM1c by , cyclin E/Cdk and cyclin A/Cdk2 or for the *repression* of [FOXM1c] by p27 . Negative_regulation FOXM1 FOXO1 23152492 2729641 In vivo , combined loss of and FoxO3 specifically in cardiomyocytes *leads* to delayed cell-cycle withdrawal and increased expression of IGF1 and [FoxM1] . Negative_regulation FOXM1 IFI27 18206647 1870575 In contrast , we now demonstrate that this LXL-motif is not required for the activation of FOXM1c by cyclin D1/Cdk4 , cyclin E/Cdk and cyclin A/Cdk2 or for the *repression* of [FOXM1c] by . Negative_regulation FOXO1 ADAM17 19877183 2187959 overexpression significantly *impaired* insulin dependent phosphorylation of AKT , GSK3 , and [FoxO1] in mouse hepatocytes . Negative_regulation FOXO1 ADIPOQ 16041833 1525194 The severe insulin resistance predominantly in epididymal adipose tissue of WOKW rats is associated with a 10-fold decrease in adipocyte gene expression , decreased Ppar gamma , but *increased* [Foxo1] gene expression compared to DA rats . Negative_regulation FOXO1 AKT1 10358014 618623 We have examined the possible *role* of in the regulation of [FKHR] . Negative_regulation FOXO1 AKT1 10602488 574788 Here we show that , but not inactive Akt , *represses* the transcriptional activity of [FKHR] , another member of the forkhead family . Negative_regulation FOXO1 AKT1 10602488 574791 [FKHR] mutants with alanine substitutions at three Akt phosphorylation consensus sites ( T24 , S256 and S319 ) were *inhibited* by , but mutation of all three sites rendered FKHR resistant to suppression . Negative_regulation FOXO1 AKT1 10602488 574794 By contrast , the transcriptional activity of the oncogenic [PAX3-FKHR] fusion protein , containing two consensus phosphorylation sites , was not *inhibited* by . Negative_regulation FOXO1 AKT1 10602488 574800 Importantly , *inhibited* the translocation of [FKHR] to the nucleus , providing a mechanism by which Akt might regulate the transcriptional activity of FKHR . Negative_regulation FOXO1 AKT1 10602488 574809 These results provide evidence that *inhibits* the transcriptional activity of [FKHR] by controlling its trafficking into the nucleus and that oncogenic PAX3-FKHR can escape this negative regulation by Akt . Negative_regulation FOXO1 AKT1 10960473 751689 Coexpression of the Forkhead transcription factor [FKHR] stimulates the glucose-6-phosphatase promoter activity via interaction with an insulin response unit (IRU) , and this activation is *suppressed* by . Negative_regulation FOXO1 AKT1 15057313 1230167 Inhibition of *increased* the [FKHR/Bim] response and DNA fragmentation within the normally resistant cortex . Negative_regulation FOXO1 AKT1 15109499 1240875 IGF-1 treatment or overexpression *inhibits* [Foxo] and atrogin-1 expression . Negative_regulation FOXO1 AKT1 15917664 1445755 Activation of by growth factors *results* in phosphorylation of nuclear [FOXO] at specific sites followed by additional phosphorylations mediated by other kinases . Negative_regulation FOXO1 AKT1 17030814 1634459 In addition , we show that Ang-2 , like Ang-1 , activates signaling in vivo , thereby *inhibiting* the expression of [FOXO1] target genes . Negative_regulation FOXO1 AKT1 17055976 1636515 [FOXO] activity is *inhibited* by the insulin effector kinase ; Negative_regulation FOXO1 AKT1 17215387 1681925 Our results raise the possibility that neurofibroma formation in individuals with neurofibromatosis might result in part from a *dependent* inhibition of [FOXO] within Schwann cells . Negative_regulation FOXO1 AKT1 18096667 1883049 Inhibition of in Ishikawa cells also *increased* nuclear [FOXO1] protein levels . Negative_regulation FOXO1 AKT1 18511845 1945193 Insulin or adenovirus mediated expression of constitutively active *inhibited* [FoxO1] and Smad3 synergy . Negative_regulation FOXO1 AKT1 18925359 2047081 Interestingly , activation of -- although coincident with a phosphorylation of Akt substrates , such as glycogen synthase kinase-3 -- did not *result* in significant nuclear exclusion of [FoxO1a] . Negative_regulation FOXO1 AKT1 19208742 2039211 *Activation* of [FoxO] transcription factors by inhibition of phosphatidylinositol <3-kinase/AKT> signaling resulted in a synergistic increase in CA-4P mediated CTGF induction . Negative_regulation FOXO1 AKT1 19513505 2092296 Phosphorylated *leads* to the inhibition of [FOXO1] activity by direct phosphorylation and cytoplasmic sequestration . Negative_regulation FOXO1 AKT1 19513505 2092299 Inhibition of using RNA interference *resulted* in the accumulation of [FOXO1] in A549 and EBC1 cell nuclei , and in accelerated apoptosis induction . Negative_regulation FOXO1 AKT1 19513505 2092305 In NSCLC cells , where FOXO1 was present in the cytoplasm constitutively , inhibition of *led* to [FOXO1] translocation to the nucleus and initiation of apoptosis . Negative_regulation FOXO1 AKT1 19944124 2198880 Unlike the JNK inhibitor SP600125 , inhibitor IV blocked the anti-lipotoxic effect of ghrelin and *stimulated* [Foxo1] nuclear translocation . Negative_regulation FOXO1 AKT1 20435456 2374934 Hepatic phosphorylation was elevated ( P < .05 ) and FoxO1 protein in hepatic nuclear extracts was *reduced* ( P < .05 ) in the face of hyperinsulinemia , whereas no increase in Akt phosphorylation or decrease in nuclear [FoxO1] was observed in skeletal muscle . Negative_regulation FOXO1 AKT1 20620993 2286726 Thus , EAK-7 and *inhibit* [DAF-16/FoxO] activity via distinct mechanisms . Negative_regulation FOXO1 AKT1 22072736 2534174 Moreover , inhibition of with MK2206 , an allosteric AKT inhibitor , dramatically *increased* the accumulation of nuclear [FOXO1] as well as expression of IGFBP1 . Negative_regulation FOXO1 AKT1 22248233 2569422 The IIS [ insulin/IGF-1 ( insulin-like growth factor-1 ) signalling ] kinase ( protein kinase B ) *inhibits* the transcription factor [FOXO1a] ( forkhead box O1a ) by phosphorylating it on residues that trigger its exit from the nucleus . Negative_regulation FOXO1 AKT1 22515357 2584463 Infection with oipA mutants reduced PI3K/Akt activation and inhibited FoxO1/3a phosphorylation , whereas infection with cag PAI mutants reduced activity but did not *inhibit* [FoxO1/3a] activation . Negative_regulation FOXO1 AKT1 23645209 2805221 Active *prevents* [FoxO] nuclear localization , which precludes Bcl-6 expression and leads to Bcl-xL overexpression . Negative_regulation FOXO1 AKT1 24107448 2878884 Subsequent experiments in alveolar rhabdomyosarcoma cells showed that activation of by thapsigargin *inhibited* [PAX3-FOXO1] activity via phosphorylation . Negative_regulation FOXO1 AKT1 24453252 2913002 Our findings not only identify Mst kinases as the long-searched-for factors that simultaneously activate [Foxo1/3] and *inhibit* TCR stimulated downstream of TCR signaling to promote Foxp3 expression and Treg development , but also shed new light on understanding and designing better therapeutic strategies for MST1 deficiency mediated human immunodeficiency syndrome . Negative_regulation FOXO1 AKT2 10358014 618624 We have examined the possible *role* of in the regulation of [FKHR] . Negative_regulation FOXO1 AKT2 10602488 574789 Here we show that Akt , but not inactive , *represses* the transcriptional activity of [FKHR] , another member of the forkhead family . Negative_regulation FOXO1 AKT2 10602488 574792 [FKHR] mutants with alanine substitutions at three Akt phosphorylation consensus sites ( T24 , S256 and S319 ) were *inhibited* by , but mutation of all three sites rendered FKHR resistant to suppression . Negative_regulation FOXO1 AKT2 10602488 574795 By contrast , the transcriptional activity of the oncogenic [PAX3-FKHR] fusion protein , containing two consensus phosphorylation sites , was not *inhibited* by . Negative_regulation FOXO1 AKT2 10602488 574801 Importantly , *inhibited* the translocation of [FKHR] to the nucleus , providing a mechanism by which Akt might regulate the transcriptional activity of FKHR . Negative_regulation FOXO1 AKT2 10602488 574810 These results provide evidence that *inhibits* the transcriptional activity of [FKHR] by controlling its trafficking into the nucleus and that oncogenic PAX3-FKHR can escape this negative regulation by Akt . Negative_regulation FOXO1 AKT2 15057313 1230168 Inhibition of *increased* the [FKHR/Bim] response and DNA fragmentation within the normally resistant cortex . Negative_regulation FOXO1 AKT2 15109499 1240876 IGF-1 treatment or overexpression *inhibits* [Foxo] and atrogin-1 expression . Negative_regulation FOXO1 AKT2 15917664 1445756 Activation of by growth factors *results* in phosphorylation of nuclear [FOXO] at specific sites followed by additional phosphorylations mediated by other kinases . Negative_regulation FOXO1 AKT2 17030814 1634460 In addition , we show that Ang-2 , like Ang-1 , activates signaling in vivo , thereby *inhibiting* the expression of [FOXO1] target genes . Negative_regulation FOXO1 AKT2 17055976 1636516 [FOXO] activity is *inhibited* by the insulin effector kinase ; Negative_regulation FOXO1 AKT2 17215387 1681926 Our results raise the possibility that neurofibroma formation in individuals with neurofibromatosis might result in part from a dependent *inhibition* of [FOXO] within Schwann cells . Negative_regulation FOXO1 AKT2 18096667 1883050 Inhibition of in Ishikawa cells also *increased* nuclear [FOXO1] protein levels . Negative_regulation FOXO1 AKT2 18925359 2047082 Interestingly , activation of -- although coincident with a phosphorylation of Akt substrates , such as glycogen synthase kinase-3 -- did not *result* in significant nuclear exclusion of [FoxO1a] . Negative_regulation FOXO1 AKT2 19208742 2039212 *Activation* of [FoxO] transcription factors by inhibition of phosphatidylinositol <3-kinase/AKT> signaling resulted in a synergistic increase in CA-4P mediated CTGF induction . Negative_regulation FOXO1 AKT2 19513505 2092297 Phosphorylated *leads* to the inhibition of [FOXO1] activity by direct phosphorylation and cytoplasmic sequestration . Negative_regulation FOXO1 AKT2 19513505 2092300 Inhibition of using RNA interference *resulted* in the accumulation of [FOXO1] in A549 and EBC1 cell nuclei , and in accelerated apoptosis induction . Negative_regulation FOXO1 AKT2 19513505 2092306 In NSCLC cells , where FOXO1 was present in the cytoplasm constitutively , inhibition of *led* to [FOXO1] translocation to the nucleus and initiation of apoptosis . Negative_regulation FOXO1 AKT2 19944124 2198881 Unlike the JNK inhibitor SP600125 , inhibitor IV blocked the anti-lipotoxic effect of ghrelin and *stimulated* [Foxo1] nuclear translocation . Negative_regulation FOXO1 AKT2 20435456 2374935 Hepatic phosphorylation was elevated ( P < .05 ) and FoxO1 protein in hepatic nuclear extracts was *reduced* ( P < .05 ) in the face of hyperinsulinemia , whereas no increase in Akt phosphorylation or decrease in nuclear [FoxO1] was observed in skeletal muscle . Negative_regulation FOXO1 AKT2 22072736 2534175 Moreover , inhibition of with MK2206 , an allosteric AKT inhibitor , dramatically *increased* the accumulation of nuclear [FOXO1] as well as expression of IGFBP1 . Negative_regulation FOXO1 AKT2 22248233 2569423 The IIS [ insulin/IGF-1 ( insulin-like growth factor-1 ) signalling ] kinase ( protein kinase B ) *inhibits* the transcription factor [FOXO1a] ( forkhead box O1a ) by phosphorylating it on residues that trigger its exit from the nucleus . Negative_regulation FOXO1 AKT2 22515357 2584464 Infection with oipA mutants reduced PI3K/Akt activation and inhibited FoxO1/3a phosphorylation , whereas infection with cag PAI mutants reduced activity but did not *inhibit* [FoxO1/3a] activation . Negative_regulation FOXO1 AKT2 23645209 2805222 Active *prevents* [FoxO] nuclear localization , which precludes Bcl-6 expression and leads to Bcl-xL overexpression . Negative_regulation FOXO1 AKT2 24107448 2878885 Subsequent experiments in alveolar rhabdomyosarcoma cells showed that activation of by thapsigargin *inhibited* [PAX3-FOXO1] activity via phosphorylation . Negative_regulation FOXO1 AKT2 24453252 2913003 Our findings not only identify Mst kinases as the long-searched-for factors that simultaneously activate [Foxo1/3] and *inhibit* TCR stimulated downstream of TCR signaling to promote Foxp3 expression and Treg development , but also shed new light on understanding and designing better therapeutic strategies for MST1 deficiency mediated human immunodeficiency syndrome . Negative_regulation FOXO1 AKT3 10358014 618625 We have examined the possible *role* of in the regulation of [FKHR] . Negative_regulation FOXO1 AKT3 10602488 574790 Here we show that Akt , but not inactive , *represses* the transcriptional activity of [FKHR] , another member of the forkhead family . Negative_regulation FOXO1 AKT3 10602488 574793 [FKHR] mutants with alanine substitutions at three Akt phosphorylation consensus sites ( T24 , S256 and S319 ) were *inhibited* by , but mutation of all three sites rendered FKHR resistant to suppression . Negative_regulation FOXO1 AKT3 10602488 574796 By contrast , the transcriptional activity of the oncogenic [PAX3-FKHR] fusion protein , containing two consensus phosphorylation sites , was not *inhibited* by . Negative_regulation FOXO1 AKT3 10602488 574802 Importantly , *inhibited* the translocation of [FKHR] to the nucleus , providing a mechanism by which Akt might regulate the transcriptional activity of FKHR . Negative_regulation FOXO1 AKT3 10602488 574811 These results provide evidence that *inhibits* the transcriptional activity of [FKHR] by controlling its trafficking into the nucleus and that oncogenic PAX3-FKHR can escape this negative regulation by Akt . Negative_regulation FOXO1 AKT3 15057313 1230169 Inhibition of *increased* the [FKHR/Bim] response and DNA fragmentation within the normally resistant cortex . Negative_regulation FOXO1 AKT3 15109499 1240877 IGF-1 treatment or overexpression *inhibits* [Foxo] and atrogin-1 expression . Negative_regulation FOXO1 AKT3 15917664 1445757 Activation of by growth factors *results* in phosphorylation of nuclear [FOXO] at specific sites followed by additional phosphorylations mediated by other kinases . Negative_regulation FOXO1 AKT3 17030814 1634461 In addition , we show that Ang-2 , like Ang-1 , activates signaling in vivo , thereby *inhibiting* the expression of [FOXO1] target genes . Negative_regulation FOXO1 AKT3 17055976 1636517 [FOXO] activity is *inhibited* by the insulin effector kinase ; Negative_regulation FOXO1 AKT3 17215387 1681927 Our results raise the possibility that neurofibroma formation in individuals with neurofibromatosis might result in part from a *dependent* inhibition of [FOXO] within Schwann cells . Negative_regulation FOXO1 AKT3 18096667 1883051 Inhibition of in Ishikawa cells also *increased* nuclear [FOXO1] protein levels . Negative_regulation FOXO1 AKT3 18925359 2047083 Interestingly , activation of -- although coincident with a phosphorylation of Akt substrates , such as glycogen synthase kinase-3 -- did not *result* in significant nuclear exclusion of [FoxO1a] . Negative_regulation FOXO1 AKT3 19208742 2039213 *Activation* of [FoxO] transcription factors by inhibition of phosphatidylinositol <3-kinase/AKT> signaling resulted in a synergistic increase in CA-4P mediated CTGF induction . Negative_regulation FOXO1 AKT3 19513505 2092298 Phosphorylated *leads* to the inhibition of [FOXO1] activity by direct phosphorylation and cytoplasmic sequestration . Negative_regulation FOXO1 AKT3 19513505 2092301 Inhibition of using RNA interference *resulted* in the accumulation of [FOXO1] in A549 and EBC1 cell nuclei , and in accelerated apoptosis induction . Negative_regulation FOXO1 AKT3 19513505 2092307 In NSCLC cells , where FOXO1 was present in the cytoplasm constitutively , inhibition of *led* to [FOXO1] translocation to the nucleus and initiation of apoptosis . Negative_regulation FOXO1 AKT3 19944124 2198882 Unlike the JNK inhibitor SP600125 , inhibitor IV blocked the anti-lipotoxic effect of ghrelin and *stimulated* [Foxo1] nuclear translocation . Negative_regulation FOXO1 AKT3 20435456 2374936 Hepatic phosphorylation was elevated ( P < .05 ) and FoxO1 protein in hepatic nuclear extracts was *reduced* ( P < .05 ) in the face of hyperinsulinemia , whereas no increase in Akt phosphorylation or decrease in nuclear [FoxO1] was observed in skeletal muscle . Negative_regulation FOXO1 AKT3 22072736 2534176 Moreover , inhibition of with MK2206 , an allosteric AKT inhibitor , dramatically *increased* the accumulation of nuclear [FOXO1] as well as expression of IGFBP1 . Negative_regulation FOXO1 AKT3 22248233 2569424 The IIS [ insulin/IGF-1 ( insulin-like growth factor-1 ) signalling ] kinase ( protein kinase B ) *inhibits* the transcription factor [FOXO1a] ( forkhead box O1a ) by phosphorylating it on residues that trigger its exit from the nucleus . Negative_regulation FOXO1 AKT3 22515357 2584465 Infection with oipA mutants reduced PI3K/Akt activation and inhibited FoxO1/3a phosphorylation , whereas infection with cag PAI mutants reduced activity but did not *inhibit* [FoxO1/3a] activation . Negative_regulation FOXO1 AKT3 23645209 2805223 Active *prevents* [FoxO] nuclear localization , which precludes Bcl-6 expression and leads to Bcl-xL overexpression . Negative_regulation FOXO1 AKT3 24107448 2878886 Subsequent experiments in alveolar rhabdomyosarcoma cells showed that activation of by thapsigargin *inhibited* [PAX3-FOXO1] activity via phosphorylation . Negative_regulation FOXO1 AKT3 24453252 2913004 Our findings not only identify Mst kinases as the long-searched-for factors that simultaneously activate [Foxo1/3] and *inhibit* TCR stimulated downstream of TCR signaling to promote Foxp3 expression and Treg development , but also shed new light on understanding and designing better therapeutic strategies for MST1 deficiency mediated human immunodeficiency syndrome . Negative_regulation FOXO1 AMPH 23652158 2795954 Pretreatment of animals with lithium prevented an *induced* decrease in striatal p-Akt and [p-FoxO1] levels . Negative_regulation FOXO1 ANGPT2 17030814 1634462 In addition , we show that , like Ang-1 , activates Tie2/Akt signaling in vivo , thereby *inhibiting* the expression of [FOXO1] target genes . Negative_regulation FOXO1 AR 12482965 1032779 Transcriptional analysis demonstrated that activation of the *caused* an inhibition of both wild-type [FKHR] and a mutant in which all three known AKT sites were mutated to alanines , showing that the repression is AKT independent . Negative_regulation FOXO1 AR 12482965 1032781 Further analysis demonstrated that the activated *blocked* [FKHR] 's DNA binding activity and impaired its ability to induce Fas ligand expression and prostate cancer cell apoptosis and cell cycle arrest . Negative_regulation FOXO1 ARF1 23469153 2750271 However , expression of [PAX3-FOXO1] in muscle cells alone is not sufficient and *requires* the loss of function of to promote malignant proliferation of muscle cells in vitro or initiate ARMS tumor formation in vivo . Negative_regulation FOXO1 ARF3 23469153 2750272 However , expression of [PAX3-FOXO1] in muscle cells alone is not sufficient and *requires* the loss of function of to promote malignant proliferation of muscle cells in vitro or initiate ARMS tumor formation in vivo . Negative_regulation FOXO1 ARF4 23469153 2750273 However , expression of [PAX3-FOXO1] in muscle cells alone is not sufficient and *requires* the loss of function of to promote malignant proliferation of muscle cells in vitro or initiate ARMS tumor formation in vivo . Negative_regulation FOXO1 ARF5 23469153 2750274 However , expression of [PAX3-FOXO1] in muscle cells alone is not sufficient and *requires* the loss of function of to promote malignant proliferation of muscle cells in vitro or initiate ARMS tumor formation in vivo . Negative_regulation FOXO1 ARF6 23469153 2750275 However , expression of [PAX3-FOXO1] in muscle cells alone is not sufficient and *requires* the loss of function of to promote malignant proliferation of muscle cells in vitro or initiate ARMS tumor formation in vivo . Negative_regulation FOXO1 BTK 17202334 1680910 Inhibitors of downstream components of the Btk/BLNK/PLCgamma2 pathway were used to define the mechanism by which signaling *inhibits* [FOXO1] expression . Negative_regulation FOXO1 CASP3 20354230 2260902 This occurred with increased numbers of and TUNEL positive fibroblasts , decreased fibroblast proliferation , *increased* nuclear translocation of the pro-apoptotic transcription factor [FOXO1] , and increased numbers of polymorphonuclear leukocytes , all of which were significant ( p < 0.05 ) . Negative_regulation FOXO1 CAT 24419059 2921973 Antioxidants tiron and *blocked* capsaicin mediated [JNK/FOXO/BIM] activation and protected the cells from apoptosis . Negative_regulation FOXO1 CBFA2T2 19885597 2161165 Furthermore , depletion of PI3K *resulted* in significant activation of three [Forkhead box class O (FoxO)] transcription factors , which inhibited the expression of cyclin D1 , cdk4 and induced expression of p27/Kip1 . Negative_regulation FOXO1 CD55 18025456 1832170 We find that regulates ins-7 expression in the intestine , and that preventing this regulation *blocks* [FOXO-to-FOXO] signaling from the intestine to other tissues . Negative_regulation FOXO1 CDK12 21969818 2492824 These results indicate that the FOXO1 derived peptide FO1-6nls can restore FOXO1 's tumor suppressor function by specifically opposing mediated phosphorylation and *inhibition* of [FOXO1] and hence may have a therapeutic potential for the treatment of PCa . Negative_regulation FOXO1 CDK2 17457058 1730246 However , in the presence of high levels of double-strand breaks ( DSBs ) the *mediated* inhibition of [FOXO1] is abrogated due to the ablation of CDK2 activity , and therefore the anti-apoptotic function of FOXO1 is restored . Negative_regulation FOXO1 CDKN2A 23469153 2750270 However , expression of [PAX3-FOXO1] in muscle cells alone is not sufficient and *requires* the loss of function of to promote malignant proliferation of muscle cells in vitro or initiate ARMS tumor formation in vivo . Negative_regulation FOXO1 COP 18815134 2000768 To determine the biological significance of COP1 mediated FoxO1 protein degradation , we have examined the impact of COP1 on FoxO1 mediated gene expression and found that *suppressed* FoxO1 reporter gene as well as FoxO1 target genes such as glucose-6-phosphatase and phosphoenolpyruvate carboxykinase , two key targets for [FoxO1] in the regulation of gluconeogenesis , with corresponding changes of hepatic glucose production in Fao cells . Negative_regulation FOXO1 DYRK1A 20513639 2308063 Like low concentrations of EGCG , harmine , an inhibitor of the FoxO kinase , *stimulated* [FoxO] nuclear accumulation and DNA binding activity . Negative_regulation FOXO1 ELOVL5 23099444 2717299 Elevated activity in liver and HepG2 cells *induced* rictor mRNA , rictor protein , and rictor-mTOR interaction , whereas rictor knockdown ( siRNA ) attenuated Elovl5 induction of Akt2-S ( 473 ) and [FoxO1-S] ( 256 ) phosphorylation in HepG2 cells . Negative_regulation FOXO1 FBLN1 24745730 2939277 HAND2 silencing significantly reduced the mRNA levels of , prolactin , tissue *inhibitor* of metalloproteinase 3 , interleukin-15 , and [forkhead box O1A (FOXO1A)] , but had no effect on the mRNA levels of dickkopf-1 , serum glucocorticoid kinase 1 , and insulin-like growth factor binding protein 5 . Negative_regulation FOXO1 FGF1 19244250 2054979 PDGF , , and IGF-I *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 FGF10 19244250 2054980 PDGF , , and IGF-I *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 FGF11 19244250 2054981 PDGF , , and IGF-I *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 FGF12 19244250 2054982 PDGF , , and IGF-I *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 FGF13 19244250 2054983 PDGF , , and IGF-I *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 FGF14 19244250 2054984 PDGF , , and IGF-I *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 FGF16 19244250 2054985 PDGF , , and IGF-I *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 FGF17 19244250 2054986 PDGF , , and IGF-I *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 FGF18 19244250 2054987 PDGF , , and IGF-I *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 FGF19 19244250 2054988 PDGF , , and IGF-I *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 FGF2 19244250 2054989 PDGF , , and IGF-I *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 FGF20 19244250 2054990 PDGF , , and IGF-I *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 FGF21 19244250 2054991 PDGF , , and IGF-I *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 FGF22 19244250 2054992 PDGF , , and IGF-I *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 FGF23 19244250 2054993 PDGF , , and IGF-I *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 FGF3 19244250 2054994 PDGF , , and IGF-I *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 FGF4 19244250 2054995 PDGF , , and IGF-I *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 FGF5 19244250 2054996 PDGF , , and IGF-I *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 FGF6 19244250 2054997 PDGF , , and IGF-I *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 FGF7 19244250 2054998 PDGF , , and IGF-I *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 FGF8 19244250 2054999 PDGF , , and IGF-I *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 FGF9 19244250 2055000 PDGF , , and IGF-I *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 FHL2 15692560 1376306 Overall , our data show that *inhibits* [FOXO1] activity in prostate cancer cells by promoting the deacetylation of FOXO1 by SIRT1 . Negative_regulation FOXO1 FOXA2 16644672 1553105 Gene expression and chromatin immunoprecipitation assays demonstrated that GLP-1 increases pancreatic and duodenal homeobox gene-1 and expression and *inhibits* [FoxO1] binding to both promoters . Negative_regulation FOXO1 FOXA2 21385937 2416144 Further study showed that was *involved* in regulation of [FoxO1] and PDX-1 expression in DEX induced pancreatic ß-cells dysfunction . Negative_regulation FOXO1 FOXG1 15084259 1234386 This process is negatively controlled by the PI3K pathway , a known *inhibitor* of [FoxO] localization in the nucleus , and by the telencephalic development factor , which we show binds to FoxO-Smad complexes and blocks p21Cip1 expression . Negative_regulation FOXO1 FOXO3 15798096 1390458 Together , reduced expression coupled to FOXO3a hyperphosphorylation would *suppress* [FOXO] transcriptional activity . Negative_regulation FOXO1 GAB1 19233262 2050600 Consistent with their opposite roles on Akt , the depletion of , but not of Gab2 , *results* in reduced [FOXO1] phosphorylation and VEGF mediated endothelial cell survival . Negative_regulation FOXO1 GPI 20874444 2375679 acts as a negative *regulator* of [FOXO] transcriptional activity . Negative_regulation FOXO1 HCFC1 21909281 2478518 Analogous to its role in regulating DAF-16/SIR-2.1 target genes in C. elegans , the mammalian also *repressed* the expression of several [FOXO/SIRT1] target genes . Negative_regulation FOXO1 HGF 18787186 1976050 mediated *inhibition* of [FKHR/FOXO1] activity resulted in secondary attenuation of VEGF induced expression of FKHR/FOXO1 dependent genes including vascular cell adhesion molecule-1 , manganese superoxide dismutase , endothelial specific molecule-1 , CBP/p300 interacting transactivator with ED-rich tail-2 , bone morphogenetic protein-2 , matrix metalloproteinase (MMP)-10 , and MGC5618 . Negative_regulation FOXO1 HIST2H2BE 18510339 2008753 We find that the MST1 regulatory region *enhances* [FoxO] phosphorylation while inhibiting histone phosphorylation , consistent with the cellular properties of MST1 . Negative_regulation FOXO1 HRAS 17215387 1681928 Our results raise the possibility that neurofibroma formation in individuals with neurofibromatosis might result in part from a dependent *inhibition* of [FOXO] within Schwann cells . Negative_regulation FOXO1 IGF1 19244250 2055001 PDGF , fibroblast growth factors (FGF) , and *repressed* the expression of [FOXO] genes in human fibroblasts . Negative_regulation FOXO1 IGF1 19787258 2141486 stimulation of serum starved cells *resulted* in rapid phosphorylation of Akt and [FOXO1] , and was associated with a significant increase in cell viability . Negative_regulation FOXO1 IGF1 20738286 2313475 However , the mechanisms by which inhibition of signaling and germline loss *activate* [DAF-16/FOXO] are distinct . Negative_regulation FOXO1 IGF1 21471200 2433555 and insulin *prevented* [Foxo1] from inhibiting Runx2 activity by promoting Foxo1 phosphorylation and nuclear exclusion . Negative_regulation FOXO1 IGFBP7 24983498 2952609 Here , we report that *inhibited* p300 mediated [FoxO1] acetylation in an INHAT domain dependent manner . Negative_regulation FOXO1 IL1A 24269635 2898307 In cultured chondrocytes , and TNF-a *suppressed* [FOXO1] , while TGF-ß and PDGF increased FOXO1 and FOXO3 expression . Negative_regulation FOXO1 IL7 20831893 2346470 We found that *prevented* the nuclear translocation of the transcription factor , [Foxo1] , in a manner dependent on the activity of Cdc25A , resulting in decreased levels of CD62L . Negative_regulation FOXO1 INS 10702299 672623 *inhibited* [FKHR] fragment stimulated promoter activity by approximately 70 % . Negative_regulation FOXO1 INS 12724332 1106605 *inhibition* of [Foxo1-] ( 208-652 ) -stimulated transactivation is mediated by PI 3-kinase but in contrast to full-length Foxo1 , does not require either of the two PKB/Akt phosphorylation sites ( Ser253 and Ser316 ) present in the protein fragment . Negative_regulation FOXO1 INS 15546000 1337992 Moreover , we show that hepatic [Foxo1] expression becomes deregulated as a *result* of deficiency or insulin resistance , culminating in significantly elevated Foxo1 production , along with its skewed nuclear distribution , in livers of diabetic NOD or db/db mice . Negative_regulation FOXO1 INS 15890677 1445586 In contrast to its importance in regulating the transcriptional activity of Foxo1 in the absence of insulin , acetylation plays only a minor role compared with phosphorylation in *inhibition* of [Foxo1] transcriptional activity . Negative_regulation FOXO1 INS 16885156 1613830 Chromatin immunoprecipitation assay shows that *reduced* [FoxO1] and peroxisome proliferators activated receptor gamma-coactivator-1alpha but increased SREBP-1c recruitment to CYP7A1 chromatin . Negative_regulation FOXO1 INS 18511845 1945194 or adenovirus mediated expression of constitutively active AKT1 *inhibited* [FoxO1] and Smad3 synergy . Negative_regulation FOXO1 INS 18511845 1945200 Chromatin immunoprecipitation assay showed that [FoxO1] binding to Cyp7a1 chromatin was increased in diabetic rat livers and *reduced* FoxO1 binding . Negative_regulation FOXO1 INS 20501674 2294826 Increased FoxO1 activity augments the expression of insulin receptor (IR) and IR substrate (IRS)2 , which in turn inhibits [FoxO1] activity in *response* to reduced action . Negative_regulation FOXO1 INS 20738286 2313476 However , the mechanisms by which inhibition of signaling and germline loss *activate* [DAF-16/FOXO] are distinct . Negative_regulation FOXO1 INS 21145501 2356172 Reduction in signaling *activates* [DAF-16/FOXO] , which represses the transcription of germline and intestinal genes required to deliver PUFAs to oocytes in lipoprotein complexes . Negative_regulation FOXO1 INS 21471200 2433556 IGF1 and *prevented* [Foxo1] from inhibiting Runx2 activity by promoting Foxo1 phosphorylation and nuclear exclusion . Negative_regulation FOXO1 INS 21980302 2493056 Inhibition of signaling *results* in the activation of [DAF-16/FOXO] and SKN-1/Nrf transcription factors and increased animal fitness . Negative_regulation FOXO1 INS 22819708 2660312 We showed that phosphorylates the transcription factor forkhead box O1 (FOXO1) , which regulates ATGL expression and *inhibits* [FOXO1] translocation into the nucleus . Negative_regulation FOXO1 IRS2 16916938 1646396 Inhibition of degradation with rapamycin *caused* persistent [FoxO] degradation even during prolonged insulin stimulation . Negative_regulation FOXO1 KAT2B 20041807 2211206 In contrast , the transcriptional activity of [FOXO1] S253A mutant , in which an Akt phosphorylation site is replaced by alanine , was not *repressed* by . Negative_regulation FOXO1 KAT2B 20041807 2211211 Furthermore , overexpression of *increased* nuclear accumulation of [FOXO1] even in the presence of serum . Negative_regulation FOXO1 KRAS 17215387 1681929 Our results raise the possibility that neurofibroma formation in individuals with neurofibromatosis might result in part from a *dependent* inhibition of [FOXO] within Schwann cells . Negative_regulation FOXO1 MED1 22342903 2668562 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED10 22342903 2668557 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED11 22342903 2668560 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED13 22342903 2668544 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED13L 22342903 2668545 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED14 22342903 2668549 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED15 22342903 2668538 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED16 22342903 2668540 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED17 22342903 2668551 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED18 22342903 2668556 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED19 22342903 2668559 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED20 22342903 2668539 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED21 22342903 2668536 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED22 22342903 2668537 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED23 22342903 2668550 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED24 22342903 2668546 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED25 22342903 2668558 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED26 22342903 2668552 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED27 22342903 2668553 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED29 22342903 2668548 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED30 22342903 2668547 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED31 22342903 2668555 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED4 22342903 2668541 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED6 22342903 2668542 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED7 22342903 2668554 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MED8 22342903 2668543 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 MLST8 18851840 1977024 Reduced activity in S4 ( -/- ) endothelial cells *results* in decreased [FoxO1/3a] and eNOS phosphorylation , decreased endothelial cell size , and increased arterial blood pressure in S4 ( -/- ) mice . Negative_regulation FOXO1 MLST8 23800068 2802905 This hypothesis postulates that antiacne agents either enhance nuclear [FoxO] activity or *inhibit* . Negative_regulation FOXO1 MTOR 18851840 1977026 Reduced activity in S4 ( -/- ) endothelial cells *results* in decreased [FoxO1/3a] and eNOS phosphorylation , decreased endothelial cell size , and increased arterial blood pressure in S4 ( -/- ) mice . Negative_regulation FOXO1 MTOR 23800068 2802907 This hypothesis postulates that antiacne agents either enhance nuclear [FoxO] activity or *inhibit* . Negative_regulation FOXO1 MYLIP 20142475 2214450 Accordingly , PTEN and [Foxo1a] protein levels are *reduced* by overexpression , which , in turn , enhances PI3K/Akt signaling . Negative_regulation FOXO1 MYLIP 20142475 2214456 Conversely , inhibition of expression *enhances* the expression of PTEN and [Foxo1a] and dampens signaling through the PI3K/Akt signaling pathway . Negative_regulation FOXO1 MYLIP 20424141 2267998 Finally , overexpression of *increased* the level of Sirt1 effector acetylated forkhead box O transcription factors 1 ( [FoxO1] ) , an effect mimicked in EPCs following Sirt1 knockdown . Negative_regulation FOXO1 MYLIP 20935646 2337811 Here we show that in the late phase of expansion , [Foxo1] was no longer post-translationally regulated but was *inhibited* post-transcriptionally by the interleukin 2 (IL-2) induced microRNA . Negative_regulation FOXO1 MYLIP 22213032 2591802 However , *upregulation* of [FOXO1] by inhibitor was accompanied by the anti-proliferative effect in cells of 786-O and Caki-1 . Negative_regulation FOXO1 MYLIP 23721824 2819729 Taken together , our results revealed a novel mechanism of [FOXO1] suppression *mediated* by in gastric cancer . Negative_regulation FOXO1 MYLIP 24260486 2869632 Overexpression of in LNCaP cells *resulted* in a reduced [FOXO1] expression . Negative_regulation FOXO1 MYLIP 24633705 2925571 Inhibition of *caused* expression increase of tumor suppressor gene [FOXO1] , thus manipulating miR-96 expression may be a promising approach in treatment of prostate cancer . Negative_regulation FOXO1 MYLIP 24732799 2949913 We show that directly targets and *represses* [Foxo1] and Cgi58 , activators of lipolytic activity , and forced expression of miR-145 attenuates lipolysis . Negative_regulation FOXO1 NDN 22514318 2584291 forms a stable ternary complex with Sirt1 and Foxo1 , diminishes Foxo1 acetylation , and *suppresses* the transcriptional activity of [Foxo1] in vitro . Negative_regulation FOXO1 NRAS 17215387 1681930 Our results raise the possibility that neurofibroma formation in individuals with neurofibromatosis might result in part from a dependent *inhibition* of [FOXO] within Schwann cells . Negative_regulation FOXO1 OPA1 22342903 2668561 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 PAEP 24419059 2921974 Antioxidants tiron and *blocked* capsaicin mediated [JNK/FOXO/BIM] activation and protected the cells from apoptosis . Negative_regulation FOXO1 PAX7 21321994 2410774 Here we show that while inhibits MyoD dependent transcription , MyoD *enhances* [Pax7-FKHR] activity in myogenic cell cultures . Negative_regulation FOXO1 PCK1 21655268 2442297 Moreover , we found that exendin-4 treatment increased hepatic AKT and [FOXO1] phosphorylation and *inhibited* glucose-6-phosphotase ( G6P ) and ( PEPCK ) expression in young mice , but this effect was attenuated in aging mice while the insulin sensitivity showed no change in the young group but significantly improved in aging mice . Negative_regulation FOXO1 PCK2 21655268 2442298 Moreover , we found that exendin-4 treatment increased hepatic AKT and [FOXO1] phosphorylation and *inhibited* glucose-6-phosphotase ( G6P ) and ( PEPCK ) expression in young mice , but this effect was attenuated in aging mice while the insulin sensitivity showed no change in the young group but significantly improved in aging mice . Negative_regulation FOXO1 PDGFB 15961397 1440778 , tumor necrosis factor-alpha , and insulin-like growth factor 1 treatment *resulted* in the nuclear exclusion of [FoxO] , whereas PDGF-BB alone down-regulated the FoxO target gene , p27 ( kip1 ) , and enhanced cell survival and progression through the cell cycle . Negative_regulation FOXO1 PDX1 20649634 2293142 Moreover , hIAPP induced [FOXO1] but *inhibited* nucleus translocation . Negative_regulation FOXO1 PGC 21435455 2406399 promotes nitric oxide antioxidant defenses and *inhibits* [FOXO] signaling against cardiac cachexia in mice . Negative_regulation FOXO1 PI3 12724332 1106606 Insulin inhibition of [Foxo1-] ( 208-652 ) -stimulated transactivation is *mediated* by but in contrast to full-length Foxo1 , does not require either of the two PKB/Akt phosphorylation sites ( Ser253 and Ser316 ) present in the protein fragment . Negative_regulation FOXO1 PI3 16781758 1599364 VLP induced activity *resulted* in efficient downstream signaling to Akt and consequent phosphorylation of [FKHR] and GSK3beta . Negative_regulation FOXO1 PI3 18226221 1884261 Computational analyses followed by chromatin immunoprecipitations demonstrated FOXO binding to both previously known and novel sites in promoter regions of approximately one-third of the up-regulated genes , consistent with activation of [FOXO1] and FOXO3a in *response* to inhibition of . Negative_regulation FOXO1 PIK3CA 17215387 1681931 Our results raise the possibility that neurofibroma formation in individuals with neurofibromatosis might result in part from a *dependent* inhibition of [FOXO] within Schwann cells . Negative_regulation FOXO1 PIK3CA 19208742 2039214 *Activation* of [FoxO] transcription factors by inhibition of signaling resulted in a synergistic increase in CA-4P mediated CTGF induction . Negative_regulation FOXO1 PIK3CA 22291095 2551790 Further analysis revealed that the transcription factor FoxO1 is crucial for Ikaros expression and that *mediated* down-regulation of [FoxO1] suppresses Ikaros expression . Negative_regulation FOXO1 PIK3CA 22515357 2584466 Infection with oipA mutants reduced PI3K/Akt activation and inhibited FoxO1/3a phosphorylation , whereas infection with cag PAI mutants reduced activity but did not *inhibit* [FoxO1/3a] activation . Negative_regulation FOXO1 PIK3R1 17215387 1681932 Our results raise the possibility that neurofibroma formation in individuals with neurofibromatosis might result in part from a dependent *inhibition* of [FOXO] within Schwann cells . Negative_regulation FOXO1 PIK3R1 19208742 2039215 *Activation* of [FoxO] transcription factors by inhibition of signaling resulted in a synergistic increase in CA-4P mediated CTGF induction . Negative_regulation FOXO1 PIK3R1 22291095 2551791 Further analysis revealed that the transcription factor FoxO1 is crucial for Ikaros expression and that *mediated* down-regulation of [FoxO1] suppresses Ikaros expression . Negative_regulation FOXO1 PIK3R1 22515357 2584467 Infection with oipA mutants reduced PI3K/Akt activation and inhibited FoxO1/3a phosphorylation , whereas infection with cag PAI mutants reduced activity but did not *inhibit* [FoxO1/3a] activation . Negative_regulation FOXO1 PITX1 24065703 2857771 [FOXO1] suppression of basal Fshb transcription may *involve* because PITX1 interacts with FOXO1 , FOXO1 repression maps to the proximal Fshb promoter containing a PITX1 binding site , PITX1 induction of Fshb or a PITX1 binding element in CV-1 cells is decreased by FOXO1 , and FOXO1 suppresses Pitx1 mRNA and protein levels . Negative_regulation FOXO1 PPP2CA 24329853 2894923 Moreover , we show that the enhanced expression is *sufficient* to inhibit insulin induced [FoxO1] phosphorylation via blockade of insulin mediated Akt activation or/and through direct association and dephosphorylation of pS-FoxO1 . Negative_regulation FOXO1 PPP2R1A 24329853 2894924 Moreover , we show that the enhanced expression is sufficient to *inhibit* insulin induced [FoxO1] phosphorylation via blockade of insulin mediated Akt activation or/and through direct association and dephosphorylation of pS-FoxO1 . Negative_regulation FOXO1 PPP2R2B 24329853 2894925 Moreover , we show that the enhanced expression is sufficient to *inhibit* insulin induced [FoxO1] phosphorylation via blockade of insulin mediated Akt activation or/and through direct association and dephosphorylation of pS-FoxO1 . Negative_regulation FOXO1 PPP3CA 18086917 1834736 A naturally occurring variant *inhibits* [FoxO] activity and enhances skeletal muscle regeneration . Negative_regulation FOXO1 PPP3CB 18086917 1834737 A naturally occurring variant *inhibits* [FoxO] activity and enhances skeletal muscle regeneration . Negative_regulation FOXO1 PPP3CC 18086917 1834738 A naturally occurring variant *inhibits* [FoxO] activity and enhances skeletal muscle regeneration . Negative_regulation FOXO1 PRKAA1 19079687 2003243 Our data indicate [FoxO] mRNA expression is *down-regulated* by activation and energy depletion in cultured myotubes , but that a contrasting increase in FoxO1 and FoxO3 mRNA is observed in vivo with the agent ( and in response to sepsis ) suggesting the expression of these FoxOs may be controlled by other hormonal or energy sensing cues under in vivo conditions . Negative_regulation FOXO1 PRKAA1 21097394 2350279 Activated significantly *inhibited* the phosphorylation of [FOXO1] and increased MuRF1 protein expression . Negative_regulation FOXO1 PRKAA2 19079687 2003244 Our data indicate [FoxO] mRNA expression is *down-regulated* by activation and energy depletion in cultured myotubes , but that a contrasting increase in FoxO1 and FoxO3 mRNA is observed in vivo with the agent ( and in response to sepsis ) suggesting the expression of these FoxOs may be controlled by other hormonal or energy sensing cues under in vivo conditions . Negative_regulation FOXO1 PRKAA2 21097394 2350280 Activated significantly *inhibited* the phosphorylation of [FOXO1] and increased MuRF1 protein expression . Negative_regulation FOXO1 PRKAB1 19079687 2003245 Our data indicate [FoxO] mRNA expression is *down-regulated* by activation and energy depletion in cultured myotubes , but that a contrasting increase in FoxO1 and FoxO3 mRNA is observed in vivo with the agent ( and in response to sepsis ) suggesting the expression of these FoxOs may be controlled by other hormonal or energy sensing cues under in vivo conditions . Negative_regulation FOXO1 PRKAB1 21097394 2350281 Activated significantly *inhibited* the phosphorylation of [FOXO1] and increased MuRF1 protein expression . Negative_regulation FOXO1 PRKAB2 19079687 2003246 Our data indicate [FoxO] mRNA expression is *down-regulated* by activation and energy depletion in cultured myotubes , but that a contrasting increase in FoxO1 and FoxO3 mRNA is observed in vivo with the agent ( and in response to sepsis ) suggesting the expression of these FoxOs may be controlled by other hormonal or energy sensing cues under in vivo conditions . Negative_regulation FOXO1 PRKAB2 21097394 2350282 Activated significantly *inhibited* the phosphorylation of [FOXO1] and increased MuRF1 protein expression . Negative_regulation FOXO1 PRKACB 22342903 2668563 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by or silencing mediator of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 PRKACG 22342903 2668564 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by or silencing mediator of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 PRKAG1 19079687 2003247 Our data indicate [FoxO] mRNA expression is *down-regulated* by activation and energy depletion in cultured myotubes , but that a contrasting increase in FoxO1 and FoxO3 mRNA is observed in vivo with the agent ( and in response to sepsis ) suggesting the expression of these FoxOs may be controlled by other hormonal or energy sensing cues under in vivo conditions . Negative_regulation FOXO1 PRKAG1 21097394 2350283 Activated significantly *inhibited* the phosphorylation of [FOXO1] and increased MuRF1 protein expression . Negative_regulation FOXO1 PRKAG2 19079687 2003248 Our data indicate [FoxO] mRNA expression is *down-regulated* by activation and energy depletion in cultured myotubes , but that a contrasting increase in FoxO1 and FoxO3 mRNA is observed in vivo with the agent ( and in response to sepsis ) suggesting the expression of these FoxOs may be controlled by other hormonal or energy sensing cues under in vivo conditions . Negative_regulation FOXO1 PRKAG2 21097394 2350284 Activated significantly *inhibited* the phosphorylation of [FOXO1] and increased MuRF1 protein expression . Negative_regulation FOXO1 PRKAR1A 22342903 2668565 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by or silencing mediator of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 PRKAR1B 22342903 2668566 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by or silencing mediator of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 PRKAR2A 22342903 2668567 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by or silencing mediator of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 PRKAR2B 22342903 2668568 Adiponectin levels are also stimulated by [FOXO1] and AMP activated protein kinase (AMPK) , and are *suppressed* by or silencing mediator of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation FOXO1 PRL 17640988 1793164 Moreover , overexpression of SGK1 in decidualizing cells enhanced phosphorylation and cytoplasmic translocation of the forkhead transcription factor [FOXO1] and *inhibited* the expression of , a major decidual marker gene . Negative_regulation FOXO1 PRL 18599550 1972296 In rat insulinoma cells , rat *caused* 30-50 % ( P < 0.001 ) reductions in [Forkhead box O (FoxO)-1] , peroxisome proliferator activator receptor ( PPAR)-gamma coactivator-1alpha (PGC-1alpha ) , PPARalpha , and carnitine palmitoyltransferase 1 (CPT-1) mRNAs and increased Glut-2 mRNA and GSIS ; Negative_regulation FOXO1 PRL 18599550 1972298 In primary rat islets , *reduced* FoxO1 , PPARalpha , and CPT-1 mRNAs , whereas DEX increased [FoxO1] , PGC1alpha , and UCP-2 mRNAs . Negative_regulation FOXO1 PRL 18599550 1972301 induced signal transducer and activator of transcription-5 binding to a consensus sequence in the rat FoxO1 promoter , *reduced* nuclear [FoxO1] protein levels , and induced its phosphorylation and cytoplasmic redistribution . Negative_regulation FOXO1 PRMT1 18951090 1982500 Silencing of by small interfering RNA *enhanced* nuclear exclusion , polyubiquitination , and proteasomal degradation of [FOXO1] . Negative_regulation FOXO1 PTEN 23774695 2843970 overexpression *inhibited* phosphorylation of the IIS protein [FOXO] , an expected target for PTEN , in the midgut of A. stephensi . Negative_regulation FOXO1 PTPN1 20028942 2210903 The absence of in the double-mutant mice *restored* hepatic IRS1 mediated phosphatidylinositol (PI) [3-kinase/Akt/Foxo1] signaling . Negative_regulation FOXO1 QKI 24398626 2906911 Post-transcriptional *repression* of [FOXO1] by results in low levels of FOXO1 expression in breast cancer cells . Negative_regulation FOXO1 QKI 24398626 2906912 To determine whether *mediated* post-transcriptional repression of [FOXO1] indeed plays a role in cancer cells , we first detected both QKI and FOXO1 expression in four breast cancer cell lines . Negative_regulation FOXO1 QKI 24398626 2906913 ATRA , an inducer of apoptosis or differentiation , dramatically *enhanced* [FOXO1] expression while it repressed expression . Negative_regulation FOXO1 QKI 24398626 2906915 In summary , our study provides initial evidence demonstrating that *mediated* repression of [FOXO1] may be one of the factors contributing to the oncogenesis and progression of breast carcinoma , which suggests that targeting QKI may serve as a novel strategy to sensitize breast cancers to chemotherapy . Negative_regulation FOXO1 RICTOR 18851840 1977025 Reduced activity in S4 ( -/- ) endothelial cells *results* in decreased [FoxO1/3a] and eNOS phosphorylation , decreased endothelial cell size , and increased arterial blood pressure in S4 ( -/- ) mice . Negative_regulation FOXO1 RPTOR 23800068 2802906 This hypothesis postulates that antiacne agents either enhance nuclear [FoxO] activity or *inhibit* . Negative_regulation FOXO1 SCGB1D4 20178781 2236761 Thus , HSD-1 and *inhibit* [DAF-16/FoxO] activity via distinct and complementary mechanisms . Negative_regulation FOXO1 SERPINF1 19818798 2159776 The results reveal that *inhibits* AGE-BSA induced [PI3K/Akt/FKHR] signaling in PRECs . Negative_regulation FOXO1 SGK1 17640988 1793163 Moreover , overexpression of in decidualizing cells *enhanced* phosphorylation and cytoplasmic translocation of the forkhead transcription factor [FOXO1] and inhibited the expression of PRL , a major decidual marker gene . Negative_regulation FOXO1 SIRT1 23457303 2765804 In line with the in vivo results , insulin induced AKT and [FoxO1] phosphorylation were *potentiated* by inhibition of in a cultured hypothalamic cell line . Negative_regulation FOXO1 SIRT1 24773342 2944473 Brain inhibition in DIO *increased* acetylated [FoxO1] , which , in turn , increased phosphorylated FoxO1 via improved insulin/pAKT signaling . Negative_regulation FOXO1 SOX2 24116102 2852728 We determined that increases of in i-OSKM-ESC *lead* to increases in activated AKT and inactivation of FoxO1 ( an activator of Sox2 ) , as well as decreases in binding of [FoxO1] to the 5'flanking region of Sox2 . Negative_regulation FOXO1 SPAG8 20178781 2236748 Whereas IIS promotes the cytoplasmic sequestration of DAF-16/FoxO , *inhibits* nuclear [DAF-16/FoxO] activity without affecting DAF-16/FoxO subcellular localization . Negative_regulation FOXO1 SPAG8 20178781 2236760 Thus , and IIS *inhibit* [DAF-16/FoxO] activity via distinct and complementary mechanisms . Negative_regulation FOXO1 STAT3 21730069 2471506 We further show that binds directly to FoxO1 or FoxO3a promoter and that STAT3-deficiency *resulted* in down-regulation of the expression of FoxO1 , FoxO3a and [FoxO-target] genes ( I?B and p27Kip1 ) . Negative_regulation FOXO1 TCF7L2 19386626 2089260 Loss of *resulted* in decreased GLP-1 and GIP stimulated AKT phosphorylation , and AKT mediated [Foxo-1] phosphorylation and nuclear exclusion . Negative_regulation FOXO1 TIE1 17030814 1634458 In addition , we show that Ang-2 , like Ang-1 , activates signaling in vivo , thereby *inhibiting* the expression of [FOXO1] target genes . Negative_regulation FOXO1 TNF 15961397 1440777 PDGF-BB , , and insulin-like growth factor 1 treatment *resulted* in the nuclear exclusion of [FoxO] , whereas PDGF-BB alone down-regulated the FoxO target gene , p27 ( kip1 ) , and enhanced cell survival and progression through the cell cycle . Negative_regulation FOXO1 TNF 21501655 2439100 Finally , *inhibited* [Foxo1] phosphorylation and enhanced its transcriptional activity , through which TNF-a increased the expression of Angptl2 in adipocytes . Negative_regulation FOXO1 TNF 24269635 2898306 In cultured chondrocytes , IL-1ß and *suppressed* [FOXO1] , while TGF-ß and PDGF increased FOXO1 and FOXO3 expression . Negative_regulation FOXO1 TNFSF10 19470406 2097450 In this study , we found that *inhibited* PI3K/Akt dependent [FoxO] phosphorylation and relocated FoxO proteins into the nucleus from the cytosol in activated human hepatic stellate LX-2 cells . Negative_regulation FOXO1 TP53 22306819 2560495 In addition , we found that SIRT1 maintains prematurity of hematopoietic cells through ROS elimination , [FOXO] activation , and *inhibition* . Negative_regulation FOXO1 TSC22D3 20018851 2204640 *inhibits* [FOXO1] , FOXO3 , and FOXO4 transcriptional activities measured with natural or synthetic FOXO-responsive promoters in HL-60 cells . Negative_regulation FOXO1 TSC22D3 23516608 2761723 Together , these results suggest that *suppresses* [FOXO1] nuclear translocation , promotes SSC differentiation over self-renewal , and favours germ cell survival through inhibition of BIM dependent pro-apoptotic signals . Negative_regulation FOXO1 VEGFA 16077930 1442441 Overall , our data suggest that a high level of MMP-2 protein and expression may contribute to the metastatic phenotype of ARMS cells and that exogenously induced [PAX3-FKHR] expression *increases* MMP-2 secretion and invasive capability of RMS cells . Negative_regulation FOXO1 VHLL 16781758 1599363 induced PI3-kinase activity *resulted* in efficient downstream signaling to Akt and consequent phosphorylation of [FKHR] and GSK3beta . Negative_regulation FOXO1 WNT1 20966918 2338343 inhibition may also *result* in a sustained activation of [FoxO] proteins with induction of apoptosis and neuronal loss , thereby completing a vicious circle from oxidative stress , InsRes and hyperglycaemia back to the formation of ROS and consecutive neurodegeneration . Negative_regulation FOXO1 WNT11 20966918 2338344 inhibition may also *result* in a sustained activation of [FoxO] proteins with induction of apoptosis and neuronal loss , thereby completing a vicious circle from oxidative stress , InsRes and hyperglycaemia back to the formation of ROS and consecutive neurodegeneration . Negative_regulation FOXO1 WNT16 20966918 2338349 inhibition may also *result* in a sustained activation of [FoxO] proteins with induction of apoptosis and neuronal loss , thereby completing a vicious circle from oxidative stress , InsRes and hyperglycaemia back to the formation of ROS and consecutive neurodegeneration . Negative_regulation FOXO1 WNT2 20966918 2338345 inhibition may also *result* in a sustained activation of [FoxO] proteins with induction of apoptosis and neuronal loss , thereby completing a vicious circle from oxidative stress , InsRes and hyperglycaemia back to the formation of ROS and consecutive neurodegeneration . Negative_regulation FOXO1 WNT3 20966918 2338346 inhibition may also *result* in a sustained activation of [FoxO] proteins with induction of apoptosis and neuronal loss , thereby completing a vicious circle from oxidative stress , InsRes and hyperglycaemia back to the formation of ROS and consecutive neurodegeneration . Negative_regulation FOXO1 WNT4 20966918 2338347 inhibition may also *result* in a sustained activation of [FoxO] proteins with induction of apoptosis and neuronal loss , thereby completing a vicious circle from oxidative stress , InsRes and hyperglycaemia back to the formation of ROS and consecutive neurodegeneration . Negative_regulation FOXO1 WNT6 20966918 2338348 inhibition may also *result* in a sustained activation of [FoxO] proteins with induction of apoptosis and neuronal loss , thereby completing a vicious circle from oxidative stress , InsRes and hyperglycaemia back to the formation of ROS and consecutive neurodegeneration . Negative_regulation FOXO1 XBP1 22337954 2586620 At the mechanistic level , we observed that deficiency *led* to augmented expression of [Forkhead box O1 (FoxO1)] , a key transcription factor regulating autophagy in neurons . Negative_regulation FOXO1 ZGLP1 16644672 1553102 *inhibited* [FoxO1] through phosphorylation dependent nuclear exclusion in pancreatic beta ( INS832/13 ) cells . Negative_regulation FOXO1 ZGLP1 16644672 1553104 Gene expression and chromatin immunoprecipitation assays demonstrated that increases pancreatic and duodenal homeobox gene-1 and Foxa2 expression and *inhibits* [FoxO1] binding to both promoters . Negative_regulation FOXO3 FOXO1 22550000 2669315 Doxorubicin modulated [Foxo3a] binding on syndecan-2 gene promoter and induced dependent *inhibition* of Wnt/TCF activity . Negative_regulation FOXO3 FOXO1 24278276 2876876 Meanwhile , knockdown of HIF-1a also inhibited hypoxia *induced* [FoxO3a] expression in CMECs , but did not affect expression . Negative_regulation FOXO3 PGC 21435455 2406400 promotes nitric oxide antioxidant defenses and *inhibits* [FOXO] signaling against cardiac cachexia in mice . Negative_regulation FOXO3 TNF 15961397 1440779 PDGF-BB , , and insulin-like growth factor 1 treatment *resulted* in the nuclear exclusion of [FoxO] , whereas PDGF-BB alone down-regulated the FoxO target gene , p27 ( kip1 ) , and enhanced cell survival and progression through the cell cycle . Negative_regulation FOXO3 TNF 19363483 2064990 Stimulation of dendritic cells mediated by the coinhibitory molecule CTLA-4 *induced* nuclear localization of [Foxo3] , which in turn inhibited the production of interleukin 6 and . Negative_regulation FOXO3 TNFSF10 19470406 2097451 In this study , we found that *inhibited* PI3K/Akt dependent [FoxO] phosphorylation and relocated FoxO proteins into the nucleus from the cytosol in activated human hepatic stellate LX-2 cells . Negative_regulation FOXO4 PGC 21435455 2406401 promotes nitric oxide antioxidant defenses and *inhibits* [FOXO] signaling against cardiac cachexia in mice . Negative_regulation FOXO4 TNF 15961397 1440782 PDGF-BB , , and insulin-like growth factor 1 treatment *resulted* in the nuclear exclusion of [FoxO] , whereas PDGF-BB alone down-regulated the FoxO target gene , p27 ( kip1 ) , and enhanced cell survival and progression through the cell cycle . Negative_regulation FOXO4 TNFSF10 19470406 2097452 In this study , we found that *inhibited* PI3K/Akt dependent [FoxO] phosphorylation and relocated FoxO proteins into the nucleus from the cytosol in activated human hepatic stellate LX-2 cells . Negative_regulation FOXO6 PGC 21435455 2406398 promotes nitric oxide antioxidant defenses and *inhibits* [FOXO] signaling against cardiac cachexia in mice . Negative_regulation FOXO6 TNF 15961397 1440775 PDGF-BB , , and insulin-like growth factor 1 treatment *resulted* in the nuclear exclusion of [FoxO] , whereas PDGF-BB alone down-regulated the FoxO target gene , p27 ( kip1 ) , and enhanced cell survival and progression through the cell cycle . Negative_regulation FOXO6 TNFSF10 19470406 2097449 In this study , we found that *inhibited* PI3K/Akt dependent [FoxO] phosphorylation and relocated FoxO proteins into the nucleus from the cytosol in activated human hepatic stellate LX-2 cells . Negative_regulation FOXP3 IL1B 17623780 1770081 We demonstrate here that IL-6 , but not TNF-alpha or , can , in combination with TGF-beta , induce Th17 cell generation from naïve T cells and *inhibit* TGF-beta induced [Foxp3] expression . Negative_regulation FOXP3 RORC 20427770 2262564 The present study demonstrates that retinoic acid receptor related orphan , a key transcription factor in Th17 cell development , *inhibits* [FOXP3] expression in human T cells . Negative_regulation FOXP3 TLR7 21469103 2422734 Activation of dendritic cells via *reduces* [Foxp3] expression and suppressive function in induced Tregs . Negative_regulation FOXP3 TNF 17623780 1770080 We demonstrate here that IL-6 , but not or IL-1beta , can , in combination with TGF-beta , induce Th17 cell generation from naïve T cells and *inhibit* TGF-beta induced [Foxp3] expression . Negative_regulation FOXQ1 PTPRO 22126837 2542247 The findings should be replicated in independent samples , but indicate a *role* of in learning and memory , WDR72 with executive functioning , and an interaction between [FOXQ1] and SUMO1P1 for psychomotor speed . Negative_regulation FSCN1 TNF 10454982 638388 We used these ODNs to specifically *inhibit* [p55] tumor necrosis factor receptor type 1 expression and alpha mediated functions in culture assays . Negative_regulation FSHB FOXO1 24065703 2857764 Here , we demonstrate that *represses* basal and GnRH induced [Fshb] transcription in LßT2 cells . Negative_regulation FSHB FOXO1 24065703 2857776 GnRH induction of an [Fshb] promoter containing a deletion at -50/-41 or -30/-21 is not *repressed* by , suggesting that these two regions may be involved in FOXO1 suppression of GnRH induced Fshb synthesis . Negative_regulation FSHB MSX1 19262020 2100200 Transfection assay demonstrated that markedly *repressed* the basal Cga and [Fshb] gene expression , while Lhb expression was affected slightly . Negative_regulation FST IL1B 10221778 609534 Production of [follistatin] by HepG2 cells was stimulated by activin A , but was *inhibited* by both and IL-6 , indicating a complex regulatory loop is operable to modulate the effects of activin A during inflammation . Negative_regulation FSTL1 EPHB2 18519848 1922589 Adenovirus mediated overexpression of [Fstl1] protected cultured neonatal rat ventricular myocytes from hypoxia/reoxygenation induced apoptosis ( P < 0.01 ) , and this protective effect was *dependent* on the upregulation of both Akt and activities . Negative_regulation FURIN F2R 24015257 2837204 Despite no apparent direct effect on virus replication during in vitro experiments , an important *role* for in the regulation of [furin] expression in the lungs was shown for the first time . Negative_regulation FUT1 CCND1 16092977 1443506 and P21waf1 were cell cycle regulatory proteins in HSC , and taurine can *inhibit* the [HSC] cyclin D1 expression and stimulate P21waf1 expression , facilitate arresting cells in G0/G1 phase , and suppress cell proliferation . Negative_regulation FUT1 CTGF 12065687 954663 In conclusion , this study extends the *role* of in [HSC] activation and suggests that CTGF up-regulation might be a central pathway during HSC activation . Negative_regulation FUT1 EPHB2 10498647 647609 In this study , we evaluated the *role* of activation in cultured [HSC] stimulated with platelet derived growth factor ( PDGF ) and after induction of liver injury in vivo . Negative_regulation FUT1 HBEGF 22330337 2586587 Both endogenous and exogenous *inhibited* [HSC] activation in primary culture , and HB-EGF enhanced HSC migration . Negative_regulation FUT1 MMP28 16958682 1611151 In vitro experiments also demonstrated the *role* of in activation of [HSC] cultured in 3-D ECM . Negative_regulation FUT1 MMP7 16958682 1611166 In vitro experiments also demonstrated the *role* of in activation of [HSC] cultured in 3-D ECM . Negative_regulation FUT4 CD99 22020966 2612094 As upregulation of *led* to a decrease in cHL diagnosis marker CD30 and [CD15] and an increase in plasma-cell differentiation marker CD38 and the restoration of B-cell makers PAX5 , CD79a and CD19 , we suggest that downregulated CD99 leads to the prevention of plasma-cell differentiation in Hodgkin/Reed-Sternberg ( H/RS ) cells . Negative_regulation FUT4 CD99 23443779 2749220 Upregulation of *led* to the loss of classical Hodgkin 's lymphoma diagnosis marker CD30 and [CD15] and the restoration of the B-cell makers of PAX5 , CD19 , CD79a , BCL-6 , and CD10 . Negative_regulation FUT4 FUT1 15649251 1363731 Transfection of the mouse and Fut2 , and human FUT1 genes into human ovarian carcinoma derived RMG-1 cells *resulted* in 20-30-fold increases in cellular [alpha1,2-fucosyltransferase] activity , and in alteration of the glycolipid composition , including not only fucosylated products , but also precursor glycolipids . Negative_regulation FUT4 FUT2 15649251 1363732 Transfection of the mouse Fut1 and , and human FUT1 genes into human ovarian carcinoma derived RMG-1 cells *resulted* in 20-30-fold increases in cellular [alpha1,2-fucosyltransferase] activity , and in alteration of the glycolipid composition , including not only fucosylated products , but also precursor glycolipids . Negative_regulation FUT4 IL4 11093173 754980 In serum containing medium , *inhibited* CLA and related [alpha-fucosyltransferase] mRNA expression . Negative_regulation FUT4 IL4 7520882 269246 On the other hand , 100 U/ml significantly *increased* the number of CD13 , [CD15] and alpha naphthyl esterase positive cells to 48.9 +/- 5.0 per cent , 47.2 +/- 3.6 per cent and 46.1 +/- 3.0 per cent , p < 0.001 , respectively . Negative_regulation FUT4 ITGAM 8707129 376340 The basal expression of L-selectin , CD11a , and [CD15] was significantly decreased in jaundiced patients ( p < 0.05 ) and the expression of in response to stimulation with fMLP and endotoxin was significantly *impaired* in the jaundiced group . Negative_regulation FUT4 TAL1 18436863 1920980 Decreased expression in CMP *resulted* in rare erythroid colonies , in a 2-3 fold reduction of GM colony number in clonogenic assays and in a 3.6-5.6 decreased production of CD14 ( + ) [CD15] ( + ) GM cells in liquid culture . Negative_regulation FZD4 FRZB 20234818 2223870 Interestingly , soluble , a well-known *inhibitor* of [Wnt/Fzd] signaling , also blocked the effects of iloprost and Fzd 9 . Negative_regulation FZD8 TNFSF10 23445611 2765657 Inhibition of [FZD8] by siRNA in CRL2335 cells in the *presence* of cisplatin plus reduced ß-catenin and survivin levels and increased apoptosis compared with scrambled siRNA treated cells . Negative_regulation G6PC FOXO1 11467835 840750 The insulin responsive H4IIEC3 rat hepatoma cell line ( H4 cells ) was used in order to determine the *role* of the transcription factor in the regulation of phosphoenolpyruvate carboxykinase ( PEPCK ) and [glucose-6-phosphatase (G6Pase)] . Negative_regulation G6PC FOXO1 11467835 840762 Furthermore , overexpression of markedly *increased* the expression of the catalytic subunit of [G6Pase] ( basal about 2.5-fold , dexamethasone/cAMP stimulated about fivefold , respectively ) . Negative_regulation G6PC FOXO1 16840535 1632121 Correlation between ( FKHR ) and FOXO3a ( FKHRL1 ) binding and the *inhibition* of basal [glucose-6-phosphatase catalytic subunit] gene transcription by insulin . Negative_regulation G6PC FOXO1 16840535 1632123 the latter reveal a correlation between binding and the *inhibition* of basal [G6Pase] gene transcription by insulin . Negative_regulation G6PC FOXO1 23995837 2856086 siRNA knockdown of FoxO1 decreased , whereas overexpression of *increased* , TH-dependent transcriptional activation of PCK1 and [G6PC] in cultured hepatic cells . Negative_regulation G6PC MAP2K6 22521266 2630843 Consistent with this result , inhibitor *increased* expression of [G6Pase] gene and glucose output in Fao cells . Negative_regulation G6PD ARSA 714540 8032 ( 25 mg/100 ml ) did not *impair* RBC [G-6-PD] , glutathione peroxidase or catalase activity , glutathione stability , or hexose monophosphate shunt activity . Negative_regulation G6PD TNF 17303087 1711454 Tanshinone IIA potentiated tumor necrosis factor alpha (TNF-alpha) mediated nuclear accumulation of Nrf2 and expression of ARE related genes , while it reversed *induced* down-regulation of intracellular glutathione ( GSH ) , NADPH and [glucose 6-phosphate dehydrogenase] ( G6PDH ) levels . Negative_regulation GAB1 EPHB2 11896055 944414 These experiments demonstrate that EGF and HGF mediated activation *result* in divergent effects on [Gab1/PI3K] signaling . Negative_regulation GAB1 EPHB2 11896055 944418 HGF stimulated ERK activation increases the Gab1/PI3K association , whereas EGF stimulated activation *results* in a decrease in the tyrosine phosphorylation of [Gab1] and a decreased association with the PI3K . Negative_regulation GAB1 RGS16 19509421 2115981 bound the amino-terminal SH2 and inter-SH2 domains of p85alpha and *inhibited* its interaction with the EGF receptor associated adapter protein [Gab1] . Negative_regulation GAD1 IL1B 10433070 633918 We have previously demonstrated that *inhibits* [glutamic acid decarboxylase-65 (GAD-65)] and increases heat shock protein-70 ( HSP-70 ) expression in islet cells . Negative_regulation GAD2 IL1B 8781713 344308 In summary : 1 ) dramatically *inhibits* [GAD-65] expression . Negative_regulation GAL FUT4 9405672 470084 Thus , alpha1 , <2-fucosyltransferase> and alpha-galactosidase effectively *reduced* the expression of Galalpha ( 1,3 ) [Gal] on the cell surface and could be used to produce transgenic pigs with negligible levels of cell surface Galalpha ( 1,3 ) Gal , thereby having no reactivity with human serum and improving graft survival . Negative_regulation GAL GNE 16847058 1606778 Overexpression of recombinant in human embryonic kidney ( HEK AD293 ) cells *led* to an increase in mRNA levels for [ST3Gal5] ( GM3 synthase ) and ST8Sia1 ( GD3 synthase ) as well as the biosynthetic products of these sialyltransferases , the GM3 and GD3 gangliosides . Negative_regulation GAL MUC16 1400309 199432 Asialo Cowper 's gland ( ACGM ) at 5 mg/ml reaction mixture *inhibited* the transfer of [Gal] to LGBn ( 25.2 and 53.4 % respectively for 2 and 18 h incubation at 37 degrees C ) ; Negative_regulation GAL NR2F1 10668629 578685 The at-RA dependent increase in the [beta-Gal] expression was completely *inhibited* by . Negative_regulation GAP43 NR2F1 7674376 326011 represses expression of microtubule associated protein 2 (MAP2) gene and *delays* induction of [growth associated protein 43 (GAP43)] gene expression . Negative_regulation GAP43 S100B 7808229 284883 In addition , *inhibition* of [GAP-43] phosphorylation was seen with GAP-43 purified under a variety of conditions that alter acylation , suggesting that the acylation state of GAP-43 does not affect the ability of S100 beta to modulate CKII- or PKC mediated phosphorylation of GAP-43 . Negative_regulation GAPDH DAPK1 18995835 1990136 Inhibition of and ZIPK facilitates cell restoration to the basal state and *allows* renewed induction of [GAIT] target transcripts by repeated stimulation . Negative_regulation GAPDH EPHB2 22964641 2827236 In defining each pathway 's contributions , we found that AKT inhibition alone maximally *induced* [GAPDH] nuclear accumulation , whereas inhibition alone had no effect on GAPDH localization . Negative_regulation GAPDH EPHB2 22964641 2827280 Concurrent [GAPDH] nuclear accumulation and *inhibition* were required , however , to induce a significant DNA damage response , which was critical to subsequent cell death . Negative_regulation GAPDH IL1B 8454867 215385 ( 10 ( -9 ) M ) *inhibited* [GAPDH] activity about 55 % , compared with control values . Negative_regulation GAPDH MAP2K6 22964641 2827245 In defining each pathway 's contributions , we found that AKT inhibition alone maximally *induced* [GAPDH] nuclear accumulation , whereas inhibition alone had no effect on GAPDH localization . Negative_regulation GAS6 EPHB2 23274063 2737566 We also found that downregulation of [Gas6] by TM/EGF receptor axis was *mediated* by in VSMC calcification . Negative_regulation GAST CCND1 17185632 1717332 Here we show that gastrin induces transcription of cell cycle gene and protooncogene c-fos in the neuroendocrine pancreatic cell line AR42J and that this [gastrin] response is *inhibited* by endogenous inducible cAMP early repressor (ICER) . Negative_regulation GAST IL1B 19166966 2054006 Gastrin promoter assay showed that *inhibits* [gastrin] expression at the transcriptional level and part of this inhibitory process is mediated via activation of NFkappaB and involvement of HDACs . Negative_regulation GAST IL1B 24009751 2836903 These observations show that a functional NFkB p65 is important for *mediated* repression of [gastrin] . Negative_regulation GAST IL1B 24009751 2836905 Thus , the study provides mechanistic insight into the *mediated* [gastrin] repression via NFkB . Negative_regulation GC GLP1R 16257226 1518295 Here , we show by microarray analysis that hippocampal activation of ( GLP-1R ) , which is associated with improved learning and neuroprotection , *results* in suppression of the transcription factor [DBP] ( albumin D-site binding protein ) . Negative_regulation GC TNF 19625730 2112691 Interaction of with TNFR1 ( Tnfrsf1a , CD120a , p55 ) , but not TNFR2 ( Tnfrsf1b , CD120b , p75 ) , *leads* to fast downregulation of gene expression of [Dbp] and upregulation of negative regulators of the molecular clock , Per1 and Per2 , Cryptochrome-1 (Cry1) , and Differentiated embryo chondrocytes-1 ( Dec1 ) . Negative_regulation GCG CFI 2221580 142849 Smoke treated *inhibited* only 36 % of the [C5a-GcG] chemotactic activity . Negative_regulation GCH1 TNF 11832086 766556 Treatment with pentoxifylline significantly decreased plasma biopterin and levels at 2 to 8 hours after endotoxin challenge ( P < 0.05 , P < 0.01 ) , and *inhibited* [GTP-CHI] activities in the liver , lung , and myocardial tissues ( P < 0.05 ) . Negative_regulation GCK FOXO1 19740748 2158402 and HNF-4 are *involved* in regulation of hepatic [glucokinase] gene expression by resveratrol . Negative_regulation GCK IL1B 2199215 138237 *inhibits* [glucokinase] activity in clonal HIT-T15 beta-cells . Negative_regulation GDF15 MAP2K6 18413810 1894215 Pretreatment with p38 kinase inhibitor blocked the VES induced increase in NAG-1 protein and mRNA levels , whereas an inhibition of protein kinase C , Akt , c-Jun NH ( 2 ) -terminal kinase , or activity *had* no effect on VES induced [NAG-1] levels . Negative_regulation GDF15 MAP2K6 18413810 1894227 Forced expression of constitutively active MKK6 , an upstream kinase for p38 , *induced* an increase in [NAG-1] promoter activity , whereas p38 kinase inhibitor blocked induced increase in NAG-1 promoter activity . Negative_regulation GDF5 IL1B 19818765 2195999 [GDF-5] is *suppressed* by and enhances TGF-beta3 mediated chondrogenic differentiation in human rheumatoid fibroblast-like synoviocytes . Negative_regulation GDNF EPHB2 15351743 1292651 Expression of Gab1 PI3K-m in SK-N-MC human primitive neuroectodermal tumor cells expressing wild-type RET markedly impaired Akt phosphorylation , Rac1 activation , and lamellipodia formation that were *induced* by [GDNF] whereas expression of Gab1 SHP2-m partially impaired activation . Negative_regulation GDNF EPHB2 17210798 1709553 The extent of acute ERK activation and GDNF release were significantly correlated to each other in individual antidepressants , suggesting an important *role* of acute activation in [GDNF] production . Negative_regulation GDNF IL1B 17027275 1666390 Exogenous did not change GDNF protein levels in astrocyte cultures , and *diminished* [GDNF] levels in neuron-glia cultures . Negative_regulation GDNF IL1B 9351662 461183 and interferon-gamma (IFN-gamma) *induced* similar effects on [GDNF] production , whereas IL-2 and IL-6 had no significant effects . Negative_regulation GDNF PLAU 1321137 190198 A nonglycosylated high molecular weight expressed and purified from Escherichia coli *inhibited* [125I-ATF] binding to SaOS-2 cells but was also nonmitogenic . Negative_regulation GDNF SORL1 21994944 2513088 Moreover , overexpression of could *enhance* the regulated secretion of the [GDNF] prodomain-GFP fusion protein , suggesting that the prodomain of GDNF is responsible for its regulated secretion . Negative_regulation GDNF TNF 16956589 1627639 The *role* of and its receptors in the production of NGF and [GDNF] by astrocytes . Negative_regulation GEMIN8 SMN2 22454514 2637068 Notably , deficiency in SMA *leads* to the aberrant subcellular localization of [Gemin8] and PP1? in the atrophic skeletal muscles , suggesting that the function of PP1? is likely to be affected in disease . Negative_regulation GFAP IL1B 10098836 601741 Mutagenesis ( 3-bp exchanges ) in -70 to -68 bp blocked the induction of [GFAP] by TGF-beta1 and the *repression* by . Negative_regulation GFAP MAP2K6 23184878 2763699 The surface instigated cell alignment along the nanopattern , less protein adsorption , less cell adhesion , proliferation and viability , *inhibition* of [glial fibrillary acidic protein] , and 1 compared with all other substrates tested . Negative_regulation GFAP S100B 15098935 1238938 *mediated* inhibition of the phosphorylation of [GFAP] is prevented by TRTK-12 . Negative_regulation GFAP S100B 15098935 1238939 The inhibition of [GFAP] phosphorylation is most likely *due* to the binding of to the phosphorylation sites on this protein and blocking the access of these sites to the protein kinases . Negative_regulation GH1 EDN2 10479676 643461 Expression of Ca ( 2+ ) -mobilizing ( A ) receptors and their *role* in the control of Ca ( 2+ ) influx and [growth hormone] secretion in pituitary somatotrophs . Negative_regulation GH1 TNF 10198397 605243 G-CSF did not affect rectal temperature or the plasma levels of cortisol and [growth hormone] but did *induce* increases in the plasma levels of IL-1 receptor antagonist and both soluble receptors within 2 h after injection . Negative_regulation GH1 TNF 15887111 1407047 alpha blockade *restores* [growth hormone] signaling in murine colitis . Negative_regulation GH1 TNF 2752985 116299 *inhibits* [growth hormone] secretion from cultured anterior pituitary cells . Negative_regulation GHR TNF 11390427 822512 We hypothesized that *suppresses* [GHR] expression by inhibiting Sp1/Sp3 transactivators . Negative_regulation GHR TNF 24895283 2946227 Here , we show that and IL-1ß *inhibited* [GH receptor (GHR)] expression but had minor effects on the downstream suppressor of cytokine signaling (SOCS)3 , while IL-6 induced SOCS3 expression but had no effect on GHR expression in Huh-7 cells . Negative_regulation GIP GLP1R 17360984 1741213 To examine the acute effect of hyperglycemia on incretin receptor expression , a hyperglycemic clamp study was performed for 96 h with reduction of expression but *increase* in [GIP] receptor expression . Negative_regulation GIT1 TNF 17146555 1653981 NO ( 300 microg/mouse , N = 8 ) and ( 2 microg/mouse , N = 7 ) increased ( P < 0.01 ) GR and *delayed* [GIT] , mimicking the effect of LPS ( 50 microg/mouse ) . Negative_regulation GIT2 TNF 17146555 1653982 NO ( 300 microg/mouse , N = 8 ) and ( 2 microg/mouse , N = 7 ) increased ( P < 0.01 ) GR and *delayed* [GIT] , mimicking the effect of LPS ( 50 microg/mouse ) . Negative_regulation GJA1 EPHB2 23500605 2766656 HYS-32 induced activation of PKC , , and JNK , and co-treatment with the PKC inhibitor Go6976 or the ERK inhibitor PD98059 , but not the JNK inhibitor SP600125 , *prevented* the HYS-32 induced increase in [Cx43] expression and GJIC . Negative_regulation GJA1 GJB2 10342836 616514 It can be concluded that only a hormonal ratio resembling conditions during pregnancy is able to suppress the expression of both cx26 and [cx43] and that gene expression is *induced* earlier by E2 and is likely to be more sensitive to a shift in the E2 to P ratio than cx43 . Negative_regulation GJA1 HBEGF 16020536 1435109 secretion by a given cardiomyocyte in mouse left ventricles led to cellular hypertrophy and *reduced* expression of [connexin43] in the overexpressing cell and in immediately adjacent cells but not in cells farther away . Negative_regulation GJA1 IL1B 18230110 1864213 Irsogladine maleate countered the *induced* reduction in gap junctional intercellular communication and [connexin 43] levels . Negative_regulation GJA1 MAP2K6 11684338 875759 We have further shown that the decrease is associated with the receptor tyrosine kinase pathway and the inhibitor *prevents* EGF stimulated down-regulation of [Cx43] expression . Negative_regulation GJA1 TNF 15790879 1386464 Immunofluorescence analysis revealed that *reduced* the level of specific staining for [Cx43] at sites of contact between adjacent cells . Negative_regulation GJA1 TNF 18297686 1911980 *represses* [connexin43] expression in HaCat keratinocytes via activation of JNK signaling . Negative_regulation GJA1 TNF 18297686 1911981 We demonstrate that *reduces* the expression of [Cx43] in HaCat cell lines at the protein and mRNA levels , and transcriptionally . Negative_regulation GJA1 TNF 23768164 2820209 We have now examined the role of mitogen activated protein kinase (MAPK) signaling pathways in *induced* downregulation of the gap junction protein [connexin43 (Cx43)] in human corneal fibroblasts . Negative_regulation GJA1 TNF 23768164 2820210 *reduced* the abundance of [Cx43] in human corneal fibroblasts ( as revealed by immunoblot analysis ) as well as induced the loss of specific staining for this protein ( as revealed by immunofluorescence analysis ) . Negative_regulation GJA3 TNF 8875431 390049 *inhibits* Schwann cell proliferation , [connexin46] expression , and gap junctional communication . Negative_regulation GJB2 F2RL1 22391066 2566578 The suppression of Cx26 in HDM sensitized AR patients is related to a PAR2 mediated pathway and might serve during the initiation and maintenance of AR. Targeting the *mediated* [Cx26] suppression may be a potential means of preventing allergic sensitization . Negative_regulation GJB2 GJA1 9230274 443722 During carcinogenesis , the increased expression of Cx26 and proteins and their transcripts and co-localization of both proteins occurred in papillomas , and the expression of [Cx26] was *reduced* as cancer cells became morphologically less differentiated . Negative_regulation GJB2 GJB6 19047647 1999199 Overexpression of in the Cx30 KO mouse by transduction with bovine adeno associated virus *restored* [Cx26] expression , permitted the formation of functional gap junction channels , and rescued propagating Ca ( 2+ ) signals . Negative_regulation GJB2 KDM5B 23579952 2768600 Connexin 26 (Cx26) expression is down-regulated and KDM5B ( H3K4 demethylase ) is up-regulated in the progression of bladder cancer , suggesting that [Cx26] expression may be *down-regulated* by in bladder cancer . Negative_regulation GJB2 KDM5B 23579952 2768601 Taken together , these results indicate that *represses* [Cx26] expression in the bladder cancer development . Negative_regulation GJB2 MT3 9115588 423507 In addition , FA strongly induced 1 expression and *inhibited* [connexin 26] expression in skin but did not affect expression of these genes in tumors . Negative_regulation GJB2 MT4 9115588 423506 In addition , FA strongly induced 1 expression and *inhibited* [connexin 26] expression in skin but did not affect expression of these genes in tumors . Negative_regulation GJC1 EPHB2 15652497 1364266 Loss of [GJC] was *prevented* by inhibition of activation . Negative_regulation GJC1 EPHB2 15843167 1398337 Doxorubicin induced loss of [GJC] was *mediated* by activation of extracellular signal regulated kinase ( ) -1 and ERK-2 , as demonstrated using inhibitors of ERK activation . Negative_regulation GJC1 EPHB2 15843167 1398342 Thus , *dependent* downregulation of [GJC] upon exposure to quinones may occur both by direct phosphorylation of Cx43 and in a phosphorylation independent manner . Negative_regulation GJC2 EPHB2 15652497 1364264 Loss of [GJC] was *prevented* by inhibition of activation . Negative_regulation GJC2 EPHB2 15843167 1398333 Doxorubicin induced loss of [GJC] was *mediated* by activation of extracellular signal regulated kinase ( ) -1 and ERK-2 , as demonstrated using inhibitors of ERK activation . Negative_regulation GJC2 EPHB2 15843167 1398340 Thus , *dependent* downregulation of [GJC] upon exposure to quinones may occur both by direct phosphorylation of Cx43 and in a phosphorylation independent manner . Negative_regulation GJC3 EPHB2 15652497 1364265 Loss of [GJC] was *prevented* by inhibition of activation . Negative_regulation GJC3 EPHB2 15843167 1398335 Doxorubicin induced loss of [GJC] was *mediated* by activation of extracellular signal regulated kinase ( ) -1 and ERK-2 , as demonstrated using inhibitors of ERK activation . Negative_regulation GJC3 EPHB2 15843167 1398341 Thus , *dependent* downregulation of [GJC] upon exposure to quinones may occur both by direct phosphorylation of Cx43 and in a phosphorylation independent manner . Negative_regulation GLA ANGPT1 12811821 1102909 Expression of alpha-smooth muscle ( SM ) actin , apparent in the contractile phenotype , was decreased by FN. Expressions of matrix [Gla] and osteopontin , apparent in the synthetic phenotype , were increased by FN . Ang II measured by radioimmunoassay ( RIA ) was significantly increased in human VSMC by FN. Expression of mRNAs for Ang II-generating proteases cathepsin D , cathepsin G , ACE , and chymase was increased by FN. Expressions of cathepsin D and cathepsin G proteins were also *increased* by FN. activity , which was inhibited by an aspartyl protease inhibitor pepstatin A , was readily detected in the conditioned medium from human VSMC . Negative_regulation GLA IL1B 20460758 2257490 These results suggest that stimulated cellular proliferation via MEK and *inhibited* [Gla-OSCAL] synthesis , which were both inhibited by VK ( 2 ) via gamma-carboxylation . Negative_regulation GLP1R DPP4 18801896 2012286 Here we investigated whether acute [GLP-1R] activation ( exendin-4 ) or *inhibition* ( des-F-sitagliptin ) modulates insulin action in mice using a hyperinsulinemic euglycemic clamp . Negative_regulation GLP1R DPP4 22323472 2580562 Both [GLP-1R] activation and *inhibition* exert multiple cardioprotective actions in preclinical models of cardiovascular dysfunction , and short-term studies in human subjects appear to demonstrate modest yet beneficial actions on cardiac function in subjects with ischemic heart disease . Negative_regulation GLP1R DPP4 22832924 2676838 thus the natriuretic effect of inhibition may be *mediated* by the [GLP-1R] . Negative_regulation GLP1R MAFA 21190012 2386047 Similar overexpression of *resulted* in increased Neurod1 , Nkx6-1 , Gck and [Glp1r] mRNAs and no change in insulin content but , importantly , acquisition of glucose-responsive insulin secretion . Negative_regulation GLP1R PDX1 15756539 1389825 In addition , induction of *suppressed* the expression of [glucagon-like peptide 1 receptor] ( GLP-1R ) , which resulted in marked reduction of both basal and GLP-1 agonist exendin-4 stimulated cellular cAMP levels . Negative_regulation GLP1R PDX1 20589757 2320421 Moreover , down-regulation of could *cause* the low expression of [GLP-1R] with/without palmitate treatment . Negative_regulation GLP1R ZGLP1 15686481 1371002 Specific binding of 125I-GLP-1 ( 7-36 ) amide to the [GLP-1R] was detected in several brain areas and was *inhibited* by unlabelled ( 7-36 ) amide , exendin-4 and exendin ( 9-39 ) . Negative_regulation GLUL MSX1 10901618 712776 Their synthesis was strongly inhibited by and AZA , *inhibitors* of [glutamine synthetase] and glutamate synthase . Negative_regulation GLUL MSX1 16653241 209643 Addition of , a specific *inhibitor* of [glutamine synthetase] , inhibited the nitrate dependent increase of PEPC and CA mRNA but did not affect the glutamine dependent increase of PEPC and CA mRNA levels . Negative_regulation GLUL MSX1 16664542 56049 Stichococcus bacillaris Naeg. , a green soil alga , can grow in the presence of , an *inhibitor* of [glutamine synthetase] , by maintaining a high level of NADPH-glutamate dehydrogenase activity . Negative_regulation GLUL MSX1 16666306 104606 Chlorella autotrophica , a euryhaline marine alga , and Stichococcus bacillaris , a salt-tolerant soil alga , grow in the presence of , an *inhibitor* of [glutamine synthetase] , by maintaining high levels of NADPH-glutamate dehydrogenase . Negative_regulation GLUL MSX1 16666514 126545 When these leaves were supplied with 1 millimolar methionine sulfoximine ( , an *inhibitor* of [glutamine synthetase] , GS , activity ) at the beginning of the photoperiod , levels of ammonium increased 8-to 10-fold , GS activity was inhibited 95 % , and the light stimulated increase in asparaginase activity was completely prevented , and declined to less than initial levels . Negative_regulation GLUL MSX1 18344319 1886566 To identify genome-wide responses to such organic N signals , Arabidopsis seedlings were transiently treated with ammonium nitrate in the presence or absence of , an *inhibitor* of [glutamine synthetase] , resulting in a block of Glu/Gln synthesis . Negative_regulation GLUL MSX1 20378536 2266848 Gln3 localization predominantly responds to intracellular nitrogen levels , as reflected by its stronger NCR-sensitivity , weaker response to Rap treatment , and strong response to methionine sulfoximine ( , a [glutamine synthetase] *inhibitor* ) . Negative_regulation GLUL MSX1 22039046 2516810 TorC1 inhibitor , rapamycin (Rap) , and [glutamine synthetase] *inhibitor* , , elicit responses grossly similar to those of limiting nitrogen , implicating both glutamine synthesis and TorC1 in the regulation of Gln3 and Gat1 . Negative_regulation GMPR QRICH1 6249786 11553 It is postulated that glutamine or a product of its metabolism may function under normal conditions as a negative regulatory element in the control of [guanosine monophosphate reductase] and that decreased effective intracellular levels of *result* in an increase in the level of the enzyme . Negative_regulation GMPR QRICH2 6249786 11554 It is postulated that glutamine or a product of its metabolism may function under normal conditions as a negative regulatory element in the control of [guanosine monophosphate reductase] and that decreased effective intracellular levels of *result* in an increase in the level of the enzyme . Negative_regulation GNA13 RGS16 14634662 1170947 Here , we show that *inhibits* [G alpha 13-mediated] , RhoA dependent reversal of stellation and SRE activation . Negative_regulation GNA13 RGS16 14634662 1170953 RGS4 does not bind G alpha 13 or *attenuate* [G alpha 13-dependent] responses , and neither nor RGS4 affects G alpha 12-mediated signalling . Negative_regulation GNA15 MAP2K6 8021243 262979 In addition to the inhibition of cell growth , [G alpha 16Q212L] expression significantly *inhibited* the stimulation of protein kinase C , Raf-1 , , mitogen activated protein kinase , phospholipase A2 activity , and Ca2+ mobilization in response to PDGF . Negative_regulation GNB1 RNASE1 17960042 1815000 The results indicated that : ( 1 ) The growth of ` Housui ' pollen tube could be inhibited by its stylar and pertussis toxin (PTX) , the *inhibitor* of [heterotrimeric G protein] . Negative_regulation GNB1 RNASE7 17960042 1815009 The results indicated that : ( 1 ) The growth of ` Housui ' pollen tube could be inhibited by its stylar and pertussis toxin (PTX) , the *inhibitor* of [heterotrimeric G protein] . Negative_regulation GNE EIF2S1 11041858 742260 These findings support the idea that phosphorylation of the serine 51 residue in promotes complex formation between eIF2alpha ( P ) and eIF2B and thereby *inhibits* the [GNE] activity of eIF2B . Negative_regulation GNG2 RNASE1 17960042 1815014 The results indicated that : ( 1 ) The growth of ` Housui ' pollen tube could be inhibited by its stylar and pertussis toxin (PTX) , the *inhibitor* of [heterotrimeric G protein] . Negative_regulation GNG2 RNASE7 17960042 1815023 The results indicated that : ( 1 ) The growth of ` Housui ' pollen tube could be inhibited by its stylar and pertussis toxin (PTX) , the *inhibitor* of [heterotrimeric G protein] . Negative_regulation GNRH1 FOXO1 24065703 2857777 [GnRH] induction of an Fshb promoter containing a deletion at -50/-41 or -30/-21 is not *repressed* by , suggesting that these two regions may be involved in FOXO1 suppression of GnRH induced Fshb synthesis . Negative_regulation GNRH1 IL1B 12568852 1057183 To investigate the *role* of in regulating [GnRH] mRNA expression in cultured human endometrial stromal cells using a modified semiquantitative competitive reverse transcription and polymerase chain reaction ( PCR ) . Negative_regulation GNRH1 IL1B 12568852 1057185 *mediated* regulation of stromal cell [GnRH] mRNA expression was determined by quantitative competitive PCR . Negative_regulation GNRH1 IL1B 2180683 129623 Both IL-1 alpha and , at concentrations of 0.1 nM and higher , significantly *suppressed* [LHRH] release in vitro from the medial basal hypothalamus-preoptic area . Negative_regulation GNRH1 IL1B 2226323 144392 These results suggest that IL-1 alpha and *inhibit* [LHRH-LH] release by stimulating the activity of hypothalamic endogenous opioid peptide systems . Negative_regulation GNRH1 IL1B 8348296 227036 In contrast , 50 ng was less effective ( P < 0.05 ) when administered at 08.30 h , and totally without effect when infused at 14.30 h. Infusion of 50 ng IL-1 beta also markedly *suppressed* the hypothalamic release of [LH-RH] in proestrus rats bearing a push-pull cannula into the ME , and significantly decreased plasma LH levels in both gonadectomized male and female rats . Negative_regulation GNRH1 IL1B 8401568 230824 Centrally injected *inhibits* the hypothalamic [LHRH] secretion and circulating LH levels via prostaglandins in rats . Negative_regulation GNRH1 IL6R 9641793 511037 significantly ( p < 0.01 ) *potentiated* the inhibitory effect of LPS on [LHRH] secretion . Negative_regulation GNRH1 TNF 12865328 1111873 We have previously shown that , a major proinflammatory cytokine , *suppressed* hypothalamic [GnRH] pulse generator activity and that this inhibitory effect was enhanced by alpha-helical CRH , a CRH receptor antagonist . Negative_regulation GNRH1 TNF 17192570 1663051 Second , we showed that *reduced* significantly the forskolin stimulated [LHRH] release and that the CB1-r antagonist AM251 ( 10 ( -5 ) M ) blocked that inhibition , supporting the hypothesis that TNF-alpha inhibits LHRH release , acting at least in part by activating the endocannabinoid system . Negative_regulation GNRH1 TNF 9152627 431065 mediates endotoxin *induced* suppression of [gonadotropin releasing hormone] pulse generator activity in the rat . Negative_regulation GNRH2 TNF 9152627 431066 mediates endotoxin *induced* suppression of [gonadotropin releasing hormone] pulse generator activity in the rat . Negative_regulation GP1BA CAPN8 20060803 2211985 The *role* of in the regulation of ADAM17 dependent [GPIbalpha] ectodomain shedding . Negative_regulation GP1BA F2R 8608229 352691 The experiments with TRAP showed that activation of the seven-transmembrane domain can *result* in translocation of [GPIb] , GPIX , and GPV to the SCCS independently of the GPIb mediated pathway of thrombin induced platelet activation . Negative_regulation GP1BA HES2 16987338 1617831 and HES130/0.4 *reduced* the [CD42b] , CD41/61 and CD62p expression of ADP-agonist activated platelets at 15 min after intravenous infusion . Negative_regulation GP1BB F2R 8608229 352692 The experiments with TRAP showed that activation of the seven-transmembrane domain can *result* in translocation of [GPIb] , GPIX , and GPV to the SCCS independently of the GPIb mediated pathway of thrombin induced platelet activation . Negative_regulation GP2 PLAT 11137878 770037 *inhibits* [P-glycoprotein] activity in brain endothelial cells . Negative_regulation GP2 PLAT 11137878 770041 ( 0.01-30 microgram/ml ) dose-dependently *inhibited* the functional activity of [P-glycoprotein] , assessed by rhodamine 123 accumulation in GP8 immortalized rat brain endothelial cells , but this effect was unrelated to its proteolytic activity . Negative_regulation GP2 TF 6194014 31233 The translation products were immunoprecipitated with specific antisera against alpha 1-acid [glycoprotein] , alpha 2-macroglobulin , , alpha 1-proteinase *inhibitor* and albumin . Negative_regulation GP2 TNF 15659313 1364873 *Role* of in down-regulation of hepatic cytochrome P450 and [P-glycoprotein] by endotoxin . Negative_regulation GP2 TNF 15659313 1364885 We investigated the *role* of in the down-regulation of hepatic [P-glycoprotein] and cytochrome P450 ( CYP ) by endotoxin , using TNF-alpha gene-deficient (TNF-alpha-/-) mice . Negative_regulation GP2 TNF 20197783 2281475 In this study , we used isolated rat brain capillaries to show that the *induced* reduction of [P-glycoprotein] activity was prevented by a PKCbeta ( I/II ) inhibitor , LY333531 , and mimicked by a PKCbeta ( I/II ) activator , 12-deoxyphorbol-13-phenylacetate-20-acetate ( dPPA ) . Negative_regulation GP2 TNF 20628400 2310229 Blood-brain barrier ( BBB ) [P-glycoprotein] activity is rapidly *reduced* by vascular endothelial growth factor ( VEGF ) acting via Src and by acting via protein kinase C (PKC)beta1 . Negative_regulation GP5 F2R 8608229 352688 While confirming that both thrombin and neutrophil elastase proteolyse GPV , we show that neutrophil cathepsin G , activating peptide ( TRAP ) , and a combination of ADP and epinephrine can each *result* in a decrease in the platelet surface expression of [GPV] by a nonproteolytic mechanism : a cytoskeletal mediated redistribution of platelet surface GPV to the surface connected canalicular system ( SCCS ) . Negative_regulation GP5 F2R 8608229 352693 The experiments with TRAP showed that activation of the seven-transmembrane domain can *result* in translocation of GPIb , GPIX , and [GPV] to the SCCS independently of the GPIb mediated pathway of thrombin induced platelet activation . Negative_regulation GP5 PLAT 11137878 770038 *inhibits* [P-glycoprotein] activity in brain endothelial cells . Negative_regulation GP5 PLAT 11137878 770042 ( 0.01-30 microgram/ml ) dose-dependently *inhibited* the functional activity of [P-glycoprotein] , assessed by rhodamine 123 accumulation in GP8 immortalized rat brain endothelial cells , but this effect was unrelated to its proteolytic activity . Negative_regulation GP5 TF 6194014 31234 The translation products were immunoprecipitated with specific antisera against alpha 1-acid [glycoprotein] , alpha 2-macroglobulin , , alpha 1-proteinase *inhibitor* and albumin . Negative_regulation GP5 TNF 15659313 1364874 *Role* of in down-regulation of hepatic cytochrome P450 and [P-glycoprotein] by endotoxin . Negative_regulation GP5 TNF 15659313 1364886 We investigated the *role* of in the down-regulation of hepatic [P-glycoprotein] and cytochrome P450 ( CYP ) by endotoxin , using TNF-alpha gene-deficient (TNF-alpha-/-) mice . Negative_regulation GP5 TNF 20197783 2281477 In this study , we used isolated rat brain capillaries to show that the *induced* reduction of [P-glycoprotein] activity was prevented by a PKCbeta ( I/II ) inhibitor , LY333531 , and mimicked by a PKCbeta ( I/II ) activator , 12-deoxyphorbol-13-phenylacetate-20-acetate ( dPPA ) . Negative_regulation GP5 TNF 20628400 2310231 Blood-brain barrier ( BBB ) [P-glycoprotein] activity is rapidly *reduced* by vascular endothelial growth factor ( VEGF ) acting via Src and by acting via protein kinase C (PKC)beta1 . Negative_regulation GP6 C1QTNF1 16195328 1507784 completely or partially *prevented* VWF and [GPVI-Fc4] binding to collagen , respectively . Negative_regulation GP6 PECAM1 20403098 2287889 Whereas the presence or absence of PECAM-1 had no effect on either the rate or extent of platelet adhesion or spreading on laminin , *inhibited* laminin induced phosphorylation of [GPVI-FcR] gamma-chain immunoreceptor tyrosine based activation motifs ( ITAMs ) and activation of its downstream effector , Syk kinase , and suppressed granule secretion . Negative_regulation GP6 PECAM1 21297004 2410370 These results support a model in which complexes , formed in a Lyn dependent manner , *suppress* [GPVI] signaling . Negative_regulation GP6 PLAT 11137878 770036 *inhibits* [P-glycoprotein] activity in brain endothelial cells . Negative_regulation GP6 PLAT 11137878 770040 ( 0.01-30 microgram/ml ) dose-dependently *inhibited* the functional activity of [P-glycoprotein] , assessed by rhodamine 123 accumulation in GP8 immortalized rat brain endothelial cells , but this effect was unrelated to its proteolytic activity . Negative_regulation GP6 TF 6194014 31232 The translation products were immunoprecipitated with specific antisera against alpha 1-acid [glycoprotein] , alpha 2-macroglobulin , , alpha 1-proteinase *inhibitor* and albumin . Negative_regulation GP6 TNF 15659313 1364872 *Role* of in down-regulation of hepatic cytochrome P450 and [P-glycoprotein] by endotoxin . Negative_regulation GP6 TNF 15659313 1364884 We investigated the *role* of in the down-regulation of hepatic [P-glycoprotein] and cytochrome P450 ( CYP ) by endotoxin , using TNF-alpha gene-deficient (TNF-alpha-/-) mice . Negative_regulation GP6 TNF 20197783 2281473 In this study , we used isolated rat brain capillaries to show that the *induced* reduction of [P-glycoprotein] activity was prevented by a PKCbeta ( I/II ) inhibitor , LY333531 , and mimicked by a PKCbeta ( I/II ) activator , 12-deoxyphorbol-13-phenylacetate-20-acetate ( dPPA ) . Negative_regulation GP6 TNF 20628400 2310227 Blood-brain barrier ( BBB ) [P-glycoprotein] activity is rapidly *reduced* by vascular endothelial growth factor ( VEGF ) acting via Src and by acting via protein kinase C (PKC)beta1 . Negative_regulation GP9 F2R 8608229 352694 The experiments with TRAP showed that activation of the seven-transmembrane domain can *result* in translocation of GPIb , [GPIX] , and GPV to the SCCS independently of the GPIb mediated pathway of thrombin induced platelet activation . Negative_regulation GP9 PLAT 11137878 770039 *inhibits* [P-glycoprotein] activity in brain endothelial cells . Negative_regulation GP9 PLAT 11137878 770043 ( 0.01-30 microgram/ml ) dose-dependently *inhibited* the functional activity of [P-glycoprotein] , assessed by rhodamine 123 accumulation in GP8 immortalized rat brain endothelial cells , but this effect was unrelated to its proteolytic activity . Negative_regulation GP9 TF 6194014 31235 The translation products were immunoprecipitated with specific antisera against alpha 1-acid [glycoprotein] , alpha 2-macroglobulin , , alpha 1-proteinase *inhibitor* and albumin . Negative_regulation GP9 TNF 15659313 1364875 *Role* of in down-regulation of hepatic cytochrome P450 and [P-glycoprotein] by endotoxin . Negative_regulation GP9 TNF 15659313 1364887 We investigated the *role* of in the down-regulation of hepatic [P-glycoprotein] and cytochrome P450 ( CYP ) by endotoxin , using TNF-alpha gene-deficient (TNF-alpha-/-) mice . Negative_regulation GP9 TNF 20197783 2281479 In this study , we used isolated rat brain capillaries to show that the *induced* reduction of [P-glycoprotein] activity was prevented by a PKCbeta ( I/II ) inhibitor , LY333531 , and mimicked by a PKCbeta ( I/II ) activator , 12-deoxyphorbol-13-phenylacetate-20-acetate ( dPPA ) . Negative_regulation GP9 TNF 20628400 2310233 Blood-brain barrier ( BBB ) [P-glycoprotein] activity is rapidly *reduced* by vascular endothelial growth factor ( VEGF ) acting via Src and by acting via protein kinase C (PKC)beta1 . Negative_regulation GPD1 TNF 16483873 1524727 Both and TGF-beta blocked adipose differentiation in vitro and *led* to a marked reduction in [glycerol-3-phosphate dehydrogenase] activity , a marker enzyme of adipose differentiation , by 69 % +/- 11 % and 75 % +/- 15 % , respectively . Negative_regulation GPD2 TNF 16483873 1524728 Both and TGF-beta blocked adipose differentiation in vitro and *led* to a marked reduction in [glycerol-3-phosphate dehydrogenase] activity , a marker enzyme of adipose differentiation , by 69 % +/- 11 % and 75 % +/- 15 % , respectively . Negative_regulation GPI ANGPT1 2485042 83987 In rat aortic rings , , ANG II , and BK enhanced whereas captopril ( 10 ( -3 ) M ) *attenuated* [PGI2] generation . Negative_regulation GPI ARSA 1959184 172554 In contrast with the marked *induced* decline in [PGI2-M] , PGI3-M excretion was not affected by the addition of ASA , even at the higher doses ( 4.6 +/- 0.7 ng/g and 4.9 +/- 0.5 ng/g on 325 mg per day and 325 mg four times daily , respectively ) . Negative_regulation GPI ARSA 1959184 172555 Thus , the *induced* decrease in [PGI2] may in large part be an unavoidable consequence of ASA induced platelet cyclooxygenase inhibition . Negative_regulation GPI CA12 18359199 1898619 Clinically relevant concentrations of ZNS strongly inhibit 4-AP induced epileptiform activity of hippocampal CA3 neurons in vitro , but this effect was unlikely based on *inhibition* or changes of neuronal [pHi] . Negative_regulation GPI CA12 2193541 136286 Such effects on Na+ transport and distribution are likely secondary to the alkalinization of [pHi] *induced* by inhibition . Negative_regulation GPI CA12 8336425 223908 A inhibitor , acetazolamide ( 100 microM ) *had* no clear effect on [pHi] in both normal and Cl ( - ) -deficient solutions . Negative_regulation GPI EPHB2 11171046 783701 Inhibition of Ca ( 2+ ) fluxes using BAPTA/AM [ 1,2-bis- ( o-aminophenoxy ) ethane-N , N,N ' , N'-tetra-acetic acid tetrakis ( acetoxymethyl ester ) ] blocked VEGF induced [PGI] ( 2 ) production but did not *inhibit* activation . Negative_regulation GPI EPHB2 11171046 783708 Wortmannin partially inhibited VEGF stimulation of [PGI] ( 2 ) production , but did not *inhibit* VEGF induced activity . Negative_regulation GPI TNF 12588293 1059426 At lower concentrations ( 10-100 pg mL-1 ) , increases the intracellular content of LPO and GSH , stimulates the secretion of ET-1 and TXA2 , but *inhibits* the secretion of [PGI2] in endothelial cells compared with control cells . Negative_regulation GPI TNF 7591712 334264 In the presence of 100 microM phloretin or DIDS the [pHi] of activated monocyte was reduced to control value , production was *inhibited* completely and total protein synthesis was inhibited by 61 % . Negative_regulation GPNMB FLCN 21209915 2359462 Conversely , wildtype *suppressed* [GPNMB] expression in FLCN-null cells . Negative_regulation GPNMB TP53 22290289 2636614 Doxorubicin treatment or transient overexpression of *increased* [GPNMB] expression . Negative_regulation GPR115 ADRBK1 11579104 882565 Y1 cells express [G protein coupled receptor kinase (GRK)] 2 and 5 , but stable expression of a dominant negative ( K220W ) only marginally *reduces* the desensitization by ACTH . Negative_regulation GPR115 ASIP 23434117 2755848 In vitro studies demonstrated that both the and p.Lys89Glu altered proteins *impaired* bradykinin induced [G-protein-coupled-receptor (GPCR)] signaling , which was facilitated by the wild-type Gß4 . Negative_regulation GPR115 CSK 16501257 1541376 *Role* of tyrosine kinase in [G protein coupled receptor-] and receptor tyrosine kinase induced fibroblast cell migration . Negative_regulation GPR115 CSK 8702633 375555 *Role* of in [G protein coupled receptor-] and Gbetagamma subunit mediated activation of mitogen activated protein kinases . Negative_regulation GPR115 EGF 12880866 1115794 This is the first demonstration of a *role* of receptor transactivation in the phosphorylation of a [G protein coupled receptor] . Negative_regulation GPR115 ERBB4 21898395 2554648 These results suggest that the down-regulation of expression is *induced* by [G-protein coupled receptor] stimulation . Negative_regulation GPR115 FLNA 16513120 1535695 Using short interfering RNA ( siRNA ) to selectively target the filamin A gene and silence its expression , we studied the *role* of in [G protein coupled receptor (GPCR)] signaling . Negative_regulation GPR115 INS 12167719 973278 *induces* heterologous desensitization of [G-protein coupled receptor] and insulin-like growth factor I signaling by downregulating beta-arrestin-1 . Negative_regulation GPR115 INS 12701050 1082094 The steeper decrease in [GPR] may have been *due* to a greater response to oral glyburide in those with IFG . Negative_regulation GPR115 RGS3 9858594 582316 These data indicate that *inhibits* [G protein coupled receptor] signaling by a complex mechanism involving its translocation to the membrane in addition to its established function as a GTPase activating protein . Negative_regulation GPR115 SERPINE1 15808835 1391262 Role of c-Jun NH2-terminal kinase in [G-protein coupled receptor] agonist *induced* cardiac expression . Negative_regulation GPR132 ADRBK1 11579104 882554 Y1 cells express [G protein coupled receptor kinase (GRK)] 2 and 5 , but stable expression of a dominant negative ( K220W ) only marginally *reduces* the desensitization by ACTH . Negative_regulation GPR132 ASIP 23434117 2755837 In vitro studies demonstrated that both the and p.Lys89Glu altered proteins *impaired* bradykinin induced [G-protein-coupled-receptor (GPCR)] signaling , which was facilitated by the wild-type Gß4 . Negative_regulation GPR132 CD69 10733501 678378 In addition , the absence of *led* to a slight increase in immunoglobulin ( Ig ) [G2a] and IgM responses to immunization with T-dependent and T-independent antigens . Negative_regulation GPR132 CSK 16501257 1541365 *Role* of tyrosine kinase in [G protein coupled receptor-] and receptor tyrosine kinase induced fibroblast cell migration . Negative_regulation GPR132 CSK 8702633 375544 *Role* of in [G protein coupled receptor-] and Gbetagamma subunit mediated activation of mitogen activated protein kinases . Negative_regulation GPR132 EGF 12880866 1115783 This is the first demonstration of a *role* of receptor transactivation in the phosphorylation of a [G protein coupled receptor] . Negative_regulation GPR132 ERBB4 21898395 2554637 These results suggest that the down-regulation of expression is *induced* by [G-protein coupled receptor] stimulation . Negative_regulation GPR132 FLNA 16513120 1535684 Using short interfering RNA ( siRNA ) to selectively target the filamin A gene and silence its expression , we studied the *role* of in [G protein coupled receptor (GPCR)] signaling . Negative_regulation GPR132 HDAC4 24478334 2923419 Mechanistically , YAP recruited the epigenetic repressor to *suppress* [Gpr132] gene expression via a muscle CAT element in the Gpr132 gene . Negative_regulation GPR132 INS 12167719 973267 *induces* heterologous desensitization of [G-protein coupled receptor] and insulin-like growth factor I signaling by downregulating beta-arrestin-1 . Negative_regulation GPR132 INS 12701050 1082083 The steeper decrease in [GPR] may have been *due* to a greater response to oral glyburide in those with IFG . Negative_regulation GPR132 RGS3 9858594 582305 These data indicate that *inhibits* [G protein coupled receptor] signaling by a complex mechanism involving its translocation to the membrane in addition to its established function as a GTPase activating protein . Negative_regulation GPR132 RHOA 10951580 723793 [G2A] expression resulted in activation of Rho , and transformation via G2A was *suppressed* by a dominant negative form of . Negative_regulation GPR132 SERPINE1 15808835 1391251 Role of c-Jun NH2-terminal kinase in [G-protein coupled receptor] agonist *induced* cardiac expression . Negative_regulation GPR87 ADRBK1 11579104 882634 Y1 cells express [G protein coupled receptor kinase (GRK)] 2 and 5 , but stable expression of a dominant negative ( K220W ) only marginally *reduces* the desensitization by ACTH . Negative_regulation GPR87 ASIP 23434117 2755917 In vitro studies demonstrated that both the and p.Lys89Glu altered proteins *impaired* bradykinin induced [G-protein-coupled-receptor (GPCR)] signaling , which was facilitated by the wild-type Gß4 . Negative_regulation GPR87 CSK 16501257 1541445 *Role* of tyrosine kinase in [G protein coupled receptor-] and receptor tyrosine kinase induced fibroblast cell migration . Negative_regulation GPR87 CSK 8702633 375624 *Role* of in [G protein coupled receptor-] and Gbetagamma subunit mediated activation of mitogen activated protein kinases . Negative_regulation GPR87 EGF 12880866 1115863 This is the first demonstration of a *role* of receptor transactivation in the phosphorylation of a [G protein coupled receptor] . Negative_regulation GPR87 ERBB4 21898395 2554810 These results suggest that the down-regulation of expression is *induced* by [G-protein coupled receptor] stimulation . Negative_regulation GPR87 FLNA 16513120 1535764 Using short interfering RNA ( siRNA ) to selectively target the filamin A gene and silence its expression , we studied the *role* of in [G protein coupled receptor (GPCR)] signaling . Negative_regulation GPR87 INS 12167719 973347 *induces* heterologous desensitization of [G-protein coupled receptor] and insulin-like growth factor I signaling by downregulating beta-arrestin-1 . Negative_regulation GPR87 INS 12701050 1082163 The steeper decrease in [GPR] may have been *due* to a greater response to oral glyburide in those with IFG . Negative_regulation GPR87 RGS3 9858594 582385 These data indicate that *inhibits* [G protein coupled receptor] signaling by a complex mechanism involving its translocation to the membrane in addition to its established function as a GTPase activating protein . Negative_regulation GPR87 SERPINE1 15808835 1391331 Role of c-Jun NH2-terminal kinase in [G-protein coupled receptor] agonist *induced* cardiac expression . Negative_regulation GPR88 ADRB2 23936473 2826955 In marked contrast , in non ciliated cells , [GPR88] was distributed throughout the plasma membrane and *inhibited* the response . Negative_regulation GPX1 ALOX5 9687587 522417 Nonredox <5-lipoxygenase> inhibitors *require* [glutathione peroxidase] for efficient inhibition of 5-lipoxygenase activity . Negative_regulation GPX1 ARSA 714540 8033 ( 25 mg/100 ml ) did not *impair* RBC G-6-PD , [glutathione peroxidase] or catalase activity , glutathione stability , or hexose monophosphate shunt activity . Negative_regulation GPX2 ALOX5 9687587 522418 Nonredox <5-lipoxygenase> inhibitors *require* [glutathione peroxidase] for efficient inhibition of 5-lipoxygenase activity . Negative_regulation GPX2 ARSA 714540 8034 ( 25 mg/100 ml ) did not *impair* RBC G-6-PD , [glutathione peroxidase] or catalase activity , glutathione stability , or hexose monophosphate shunt activity . Negative_regulation GPX3 ALOX5 9687587 522419 Nonredox <5-lipoxygenase> inhibitors *require* [glutathione peroxidase] for efficient inhibition of 5-lipoxygenase activity . Negative_regulation GPX3 ARSA 714540 8035 ( 25 mg/100 ml ) did not *impair* RBC G-6-PD , [glutathione peroxidase] or catalase activity , glutathione stability , or hexose monophosphate shunt activity . Negative_regulation GPX4 ALOX5 9687587 522420 Nonredox <5-lipoxygenase> inhibitors *require* [glutathione peroxidase] for efficient inhibition of 5-lipoxygenase activity . Negative_regulation GPX4 ARSA 714540 8036 ( 25 mg/100 ml ) did not *impair* RBC G-6-PD , [glutathione peroxidase] or catalase activity , glutathione stability , or hexose monophosphate shunt activity . Negative_regulation GPX5 ALOX5 9687587 522421 Nonredox <5-lipoxygenase> inhibitors *require* [glutathione peroxidase] for efficient inhibition of 5-lipoxygenase activity . Negative_regulation GPX5 ARSA 714540 8037 ( 25 mg/100 ml ) did not *impair* RBC G-6-PD , [glutathione peroxidase] or catalase activity , glutathione stability , or hexose monophosphate shunt activity . Negative_regulation GPX6 ALOX5 9687587 522422 Nonredox <5-lipoxygenase> inhibitors *require* [glutathione peroxidase] for efficient inhibition of 5-lipoxygenase activity . Negative_regulation GPX6 ARSA 714540 8038 ( 25 mg/100 ml ) did not *impair* RBC G-6-PD , [glutathione peroxidase] or catalase activity , glutathione stability , or hexose monophosphate shunt activity . Negative_regulation GPX7 ALOX5 9687587 522423 Nonredox <5-lipoxygenase> inhibitors *require* [glutathione peroxidase] for efficient inhibition of 5-lipoxygenase activity . Negative_regulation GPX7 ARSA 714540 8039 ( 25 mg/100 ml ) did not *impair* RBC G-6-PD , [glutathione peroxidase] or catalase activity , glutathione stability , or hexose monophosphate shunt activity . Negative_regulation GPX8 ALOX5 9687587 522408 Nonredox <5-lipoxygenase> inhibitors *require* [glutathione peroxidase] for efficient inhibition of 5-lipoxygenase activity . Negative_regulation GPX8 ARSA 714540 8031 ( 25 mg/100 ml ) did not *impair* RBC G-6-PD , [glutathione peroxidase] or catalase activity , glutathione stability , or hexose monophosphate shunt activity . Negative_regulation GRAP2 EPHB2 10978848 729747 The Stats translocation did not depend on inhibition by PD98059 , *inhibition* of [p38] by 1 microm SB203580 , or Src kinase family inhibition by PP1 . Negative_regulation GRAP2 EPHB2 12029621 947591 Inhibition of activity *enhanced* TGF-beta1 induced [p38] and JNK activation . Negative_regulation GRAP2 EPHB2 15964118 1428214 In addition , the malvidin treatment significantly increased the [p38] kinase expression and *inhibited* the activity , and the effects of malvidin on caspase-3 activation were blocked , respectively , by the ERK and p38 inhibitors . Negative_regulation GRAP2 EPHB2 16515784 1555050 Basal phosphorylation was elevated and basal [p38] kinase phosphorylation was *reduced* in paclitaxel non treated TB4-HeLa cells . Negative_regulation GRAP2 EPHB2 19180563 2049262 Activated *suppressed* [p38] MAPK activation and Fas/FasL protein expression . Negative_regulation GRAP2 EPHB2 19846041 2184169 Src and c-Jun N-terminal kinase (JNK) inhibitor , but not extracellular signal regulated kinase ( ) or [p38] *inhibitor* , alleviated BEFV mediated cytopathic effect and apoptosis . Negative_regulation GRAP2 EPHB2 21040760 2370448 Both Cacnb3 isoforms , similar to Fscn1 , required JNK and [p38] kinase activity for stimulation associated upregulation , and this process was *inhibited* by and PI(3)K . Negative_regulation GRAP2 EPHB2 21566137 2449503 TER reduction could be attenuated by inhibiting Ras , and Src activation , or blocking VDCC or VEGF-R2 activation , but not by *inhibiting* [P38] . Negative_regulation GRAP2 EPHB2 21687934 2455556 CFA induced phosphorylation of the was inhibited by both dizocilpine and EA , but that of [p38] was *inhibited* by EA only . Negative_regulation GRAP2 EPHB2 22700586 2633799 Two factors that promote chondrocyte differentiation , brain derived neurotrophic factor (BDNF) and C-type natriuretic peptide , increase [p38] activity while decreasing , but not completely *inhibiting* , activity . Negative_regulation GRAP2 EPHB2 23560534 2782971 Western blot confirmed that ruxolitinib blocked , and consequently STAT5 activation , sorafenib *inhibited* ERK , [P38] and STAT5 , dasatinib blocked SRC and STAT5 , and KNK437 decreased the stability of the JAK2 protein , reducing its expression . Negative_regulation GRAP2 EPHB2 9804610 544332 Anisomycin caused [p38] activation and *inhibition* quantitatively similar to those produced by phenylephrine . Negative_regulation GRAP2 HBEGF 19010935 2022372 Furthermore , and PD169316 *prevent* [p38] phosphorylation while promoting the phosphorylation of the pro-survival SAPK/JNK and ERK . Negative_regulation GRAP2 IL1B 11087273 751208 HIV-gp120 enhancement of IL-1beta induced NO ( 2 ) ( - ) production was blocked by 10 microM of SB-203580 ( SB ) , a selective [p38] protein kinase *inhibitor* ( 3.6 +/- 0.2 vs. 6.6 +/- 0.6 micromol/1. 25 x 10 ( 5 ) cells/48 h , IL-1beta + gp120 + SB vs . + gp120 , respectively ; n = 12 , P < /= 0.5 ) . Negative_regulation GRAP2 IL1B 19214751 2071796 triggered the activation of p38 and ERK1/2 ( p44/42) MAP kinase (MAPK) signaling pathways , but WIN55,212-2 mainly *inhibited* [p38] MAPK phosphorylation . Negative_regulation GRAP2 MAP2K6 10480932 643591 Expression of dominant negative or dominant negative TAK1 *inhibited* the TGF-beta induced transcriptional activation as well as the [p38] activation . Negative_regulation GRAP2 MAP2K6 10527909 654348 In contrast to COS7 cells , in HeLa cells expression of a dominant negative mutant of SEK1 did not inhibit palytoxin stimulated activation of p38 , although expression of dominant negative mutants of either MKK3 or did *inhibit* palytoxin stimulated [p38] activation in this cell type . Negative_regulation GRAP2 MAP2K6 10849438 701164 The costimulation induced activation of [p38] was *inhibited* by dominant negative forms of Vav1 , Rac , and . Negative_regulation GRAP2 MAP2K6 10978848 729753 The Stats translocation did not depend on inhibition by PD98059 , *inhibition* of [p38] by 1 microm SB203580 , or Src kinase family inhibition by PP1 . Negative_regulation GRAP2 MAP2K6 12237315 1018786 In addition , immunoblot analysis revealed that phosphorylation of ERK was increased by treatment with the p38 inhibitors , whereas the inhibitors *increased* phosphorylation of [p38] , which implies a seesaw-like balance between ERK and p38 phosphorylation . Negative_regulation GRAP2 MAP2K6 19937254 2240957 Interestingly , in non-UVB exposed human melanocytes , a inhibitor *stimulated* the phosphorylation of [p38/CREB] which was associated with an increased production of MITF and KIT in a pattern similar to that induced by UVB . Negative_regulation GRAP2 MAP2K6 20413844 2256413 inhibition or ERK1/2 suppression *caused* activation of [p38alpha] in a K-ras dependent manner . Negative_regulation GRAP2 MAP2K6 22920673 2710162 We next analysed the effects of inhibiting signalling downstream of Ras , by specific *inhibitors* of [p38MAPK] , PI3-K or , on reoviral killing examined by MTT assay . Negative_regulation GRAP2 MMP7 17115023 1677212 We found statistically significant correlations between metastatic tumor spread and overexpression of , MMP10/2 , tissue *inhibitor* of metalloproteinase 3 , vascular endothelial growth factor ( VEGF ) , [P38] , stromal NF-kappaB , and synaptophysin . Negative_regulation GRAP2 PECAM1 19096001 2036115 These findings reveal that [p38MAPK] phosphorylation and platelet activation by LDL are *suppressed* by two mechanisms : ( 1 ) short activation of , and ( 2 ) prolonged activation of SHP-1 and SHP-2 . Negative_regulation GRAP2 PLAT 15625301 1362085 In a mouse model of focal cerebral ischemia , *induces* eNOS inhibition , ERK-2 activation , and [p38] inhibition , possibly as part of a more complex signaling response exacerbating brain injury . Negative_regulation GRAP2 SPHK1 15993704 1429712 Inhibition of SPHK-1 also did not affect EGF stimulated phosphorylation of PI-3 kinase , Akt , ERK1/2 or [p38] but inhibition of PI-3 kinase with a specific inhibitor LY294002 partly ( 40 % ) *inhibited* the EGF stimulated increase in activity . Negative_regulation GRAP2 TNF 10657669 664199 When KC was instilled as a proinflammatory stimulus , neutrophil accumulation was significantly decreased by [p38] MAPK *inhibition* independent of or LPS . Negative_regulation GRAP2 TNF 11427526 843336 We found that ethanol did not inhibit [p38] phosphorylation upon *stimulation* with either GM-CSF or . Negative_regulation GRAP2 TNF 12684435 1078021 In DRG , [p38] *activation* is blocked by systemic inhibition . Negative_regulation GRAP2 TNF 15519192 1328832 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as TNFalpha production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* [p38] MAPK activation . Negative_regulation GRAP2 TNF 16207331 1464313 In vivo , overexpression of *induced* activation of [p38MAPKalpha] and ERK in the synovial membrane , whereas activation of JNK was less pronounced and rarely observed on immunohistochemical analysis . Negative_regulation GRAP2 TNF 17151142 1732363 To fully evaluate the *role* of in myogenic activation of [p38] , we tried to determine whether p38 activation in differentiating myoblasts requires autocrine TNF-alpha , and whether forced activation of p38 rescues impaired myogenesis and regeneration in the p55 ( -/- ) p75 ( -/- ) soleus . Negative_regulation GRAP2 TNF 17214640 1681794 Roxithromycin significantly inhibited induced c-Jun N-terminal kinase activation ( JNP ) and marginally *inhibited* extracellular signal regulated kinase ( ERK ) 1/2 activation , but not [p38] mitogen activated protein kinase activation . Negative_regulation GRAP2 TNF 17264149 1696909 Disrupting signaling by TNF-alpha neutralizing antibody or knocking out TNF-alpha receptors *blocked* stretch activation of [p38] , but not ERK1/2 , JNK or AKT . Negative_regulation GRAP2 TNF 17438131 1742707 Overexpression of alpha-4 suppressed [p38] MAPK activation in *response* to . Negative_regulation GRAP2 TNF 19938896 2190510 MEHP also *induced* phosphorylation of MAPK [p38] , while the p38 inhibitor SB 202190 reduced MEHP induced , suggesting a p38 dependent cytokine production . Negative_regulation GRAP2 TNF 21042558 2344365 Genistein represses the release of and significantly *inhibits* ERK and [P38] phosphorylation in activated microglial cells by acting as a tyrosine kinase inhibitor . Negative_regulation GRAP2 TNF 22198506 2558715 MKP1 attenuates ERK1/2 and [p38] activation , *inhibits* myocardial expression , and improves cardiac function in endotoxemia . Negative_regulation GRAP2 TNF 22418033 2582635 Danshensu partly blocked the expression of RAGE , [p-p38] , and COX-2 , and NF-?B activation , and *inhibited* the increase of , IL-6 , and PGE2 . Negative_regulation GRAP2 TNF 22427564 2588228 BBR inhibited the expression of IL-6 , IL-8 , and MCP-1 remarkably at both protein and mRNA levels and down-regulated the phosphorylation of [p38] , ERK1/2 , and JNK upon *stimulation* with . Negative_regulation GRAP2 TNF 23258237 2741342 specifically activated p38a but not other p38 isoforms and suppression of [p38a] by an siRNA *resulted* in further amplification of the TNF-a effect . Negative_regulation GRAP2 TNF 24304472 2904836 In endotoxaemic mice , PE promoted myocardial ERK1/2 phosphorylation and c-Fos expression , *inhibited* [p38] phosphorylation and I?Ba degradation , reduced myocardial production and prevented LPS provoked cardiac dysfunction . Negative_regulation GRAP2 TNF 9177222 434134 Wortmannin , an inhibitor of phosphatidylinositol 3-kinase , diminished FcepsilonRI mediated synthesis , significantly blunted JNK activation and TNF-alpha promoter-driven luciferase expression , and only weakly *inhibited* [p38] kinase activation . Negative_regulation GRIA1 HBEGF 16443372 1540536 Subchronic stimulation of ErbB1 with transforming growth factor alpha ( TGFalpha ) , EGF , or *down-regulated* protein expression of the [GluR1] AMPA receptor subunit in cultured neocortical neurons . Negative_regulation GRIN1 TCN1 22022974 2591675 213 selectively *blocked* [GluN1/GluN2A] over GluN1/GluN2B NMDA receptors allowing direct dissection of functional NMDA receptors and pharmacological profiling of developmental changes in native NMDA receptor subunit composition . Negative_regulation GRIN2A TCN1 22022974 2591677 213 selectively *blocked* [GluN1/GluN2A] over GluN1/GluN2B NMDA receptors allowing direct dissection of functional NMDA receptors and pharmacological profiling of developmental changes in native NMDA receptor subunit composition . Negative_regulation GRIN2B CAPN8 14672996 1178510 An inhibitor of *blocked* both the decrease of intact [NR2B] and the increase of the low molecular weight form , whereas neither caspase nor cathepsin inhibitors had an effect on these events . Negative_regulation GSK3B AXIN2 10490650 645605 Similarly , mutants of lacking key regulatory domains such as the RGS domain , which is required for interaction with the adenomatous polyposis coli protein , bind and *inhibit* [GSK-3beta] in vivo , suggesting that these domains are critical for proper regulation of GSK-3beta activity . Negative_regulation GSK3B CCND1 18084742 1924509 In conclusion , this study demonstrated that cordycepin inhibits the proliferation of B16-BL6 cells by stimulating adenosine A3 receptors followed by the Wnt signaling pathway , including [GSK-3beta] activation and *inhibition* . Negative_regulation GSK3B FAS 11827997 909550 receptor signaling *inhibits* [glycogen synthase kinase 3 beta] and induces cardiac hypertrophy following pressure overload . Negative_regulation GSK3B FAS 11827997 909552 These findings indicate that receptor signaling *inhibits* [GSK3 beta] activity in cardiomyocytes and is required for compensation of pressure overload in vivo . Negative_regulation GSK3B IRS4 19029952 2029399 Once expressed , as well as binding to E1A and the insulin receptor , remains tyrosine phosphorylated and constitutively associates with the regulatory p85 subunit of phosphoinositide 3 kinase , *resulting* in the phosphorylation of Akt ( causing activation ) and [GSK-3beta] ( causing inhibition ) . Negative_regulation GSK3B NEDD9 19159680 2038227 This novel function of lithium does not involve inhibition of a well characterized lithium target , GSK3beta , since other known [GSK3beta] inhibitors do not *induce* degradation or Tpl2 activation . Negative_regulation GSK3B RASD1 18922798 1994424 We also demonstrate that *inhibits* the FE65-APP mediated transcription of [glycogen synthase kinase 3beta] ( GSK3 beta ) . Negative_regulation GSK3B STK39 12882964 1142712 This results in activation of phosphatidylinositol 3-kinase (PI3K) , the Akt , and the *inhibition* of [glycogen synthase kinase 3beta] , a protein that is implicated in the regulation of axonal transport . Negative_regulation GSK3B TNF 16601113 1568688 We observed that and interleukin-1beta (IL-1beta) treatment of primary cultures of human microvascular cells *reduced* net endogenous active [GSK-3beta] protein levels while inducing inflammatory cytokine ( IL-6 and monocyte chemoattractant protein-1 ( MCP-1 ) ) expression . Negative_regulation GSK3B TNF 19411063 2070937 Wu et al. , in this issue of Cancer Cell , show that dependent NFkappaB activation *induces* COP9 signalosome mediated inhibition of [GSK3beta] and the SCF(beta-TRCP) ubiquitin ligase , thus leading to stabilization of the transcription factor Snail and promoting cell migration and metastasis . Negative_regulation GSK3B TNF 19596777 2122945 Heat inactivated S. aureus activated [GSK-3beta] , and *inhibiting* GSK-3beta reduced production as well as inducible NO synthase (iNOS)/NO biosynthesis . Negative_regulation GSN SCIN 11568009 864124 Vector mediated expression of in the megakaryoblastic cell line MEG-01 *induced* a decrease in both F-actin and [gelsolin] . Negative_regulation GSR TNF 23112985 2367111 Six weeks of EPA+vitamin E supplementation *enhances* the plasma levels of IL-2 and erythrocytes [glutathione reductase] , whereas it reduces , and 6 weeks of EPA supplementation alone enhances only the serum level of MDA . Negative_regulation GSTA1 IL1B 12386123 999689 Deletion of a hepatic nuclear factor 1 (HNF-1) site in this region abrogated the *mediated* repression of [GSTA1] promoter activity . Negative_regulation GSTA1 IL1B 17021248 1674232 *Repression* of human [GSTA1] by is mediated by variant hepatic nuclear factor-1C . Negative_regulation GSTA1 IL1B 17021248 1674238 *reduced* [GSTA1] mRNA levels at all stages of confluence ; Negative_regulation GSTA1 IL1B 17021248 1674239 *repressed* [GSTA1] transcriptional activity , an effect that was abolished by mutating the HRE . Negative_regulation GSTA1 IL1B 17021248 1674240 Overexpression of HNF-1alpha did not counteract *mediated* repression of [GSTA1] transcription either in reporter assays or at the mRNA level . Negative_regulation GSTA1 IL1B 17021248 1674243 These findings indicate that *represses* [GSTA1] transcription via a mechanism involving overexpression of vHNF-1C . Negative_regulation GTF2B LBP 7836461 293692 The cellular factor , , can *repress* [HIV-1 transcription] by preventing the binding of TFIID to the promoter . Negative_regulation GUSB IL1B 7723245 301920 had no effect on the basal release of beta-glucuronidase but partially *blocked* the beta 2m induced release of [beta-glucuronidase] . Negative_regulation GYS1 ALDH2 22524197 2595806 In vitro data revealed that the activator Alda-1 and [glycogen synthase] kinase-3ß *inhibition* protected against high glucose induced mitochondrial and mechanical anomalies , the effect of which was cancelled by mitochondrial uncoupling . Negative_regulation GYS1 AXIN2 20974802 2365393 These phosphorylated motifs are required to recruit and to *inhibit* [glycogen synthase kinase 3 (GSK3)] , two basic components of the ß-catenin destruction complex . Negative_regulation GYS1 IL1B 9581683 503452 Furthermore , it was discovered that and IL-6 *inhibited* [glycogen synthase] activity and , in contrast , accelerated glycogen phosphorylase activity . Negative_regulation GYS1 TNF 8641197 362844 The effect of TNF-alpha was more pronounced when the incubation period was extended to 6 and 12 h . also *blocked* insulin activation of [glycogen synthase (GS)] and inhibited glycogen synthesis ( measured as [ 14C ] -glucose incorporated into glycogen ) . Negative_regulation GYS2 ALDH2 22524197 2595807 In vitro data revealed that the activator Alda-1 and [glycogen synthase] kinase-3ß *inhibition* protected against high glucose induced mitochondrial and mechanical anomalies , the effect of which was cancelled by mitochondrial uncoupling . Negative_regulation GYS2 AXIN2 20974802 2365395 These phosphorylated motifs are required to recruit and to *inhibit* [glycogen synthase kinase 3 (GSK3)] , two basic components of the ß-catenin destruction complex . Negative_regulation GYS2 IL1B 9581683 503454 Furthermore , it was discovered that and IL-6 *inhibited* [glycogen synthase] activity and , in contrast , accelerated glycogen phosphorylase activity . Negative_regulation GYS2 TNF 8641197 362845 The effect of TNF-alpha was more pronounced when the incubation period was extended to 6 and 12 h . also *blocked* insulin activation of [glycogen synthase (GS)] and inhibited glycogen synthesis ( measured as [ 14C ] -glucose incorporated into glycogen ) . Negative_regulation H1F0 TNF 14681231 1211290 We next established that dose-dependently *inhibits* IGF-I induced phosphorylation of both RB and [histone H1] by cyclin A-dependent cyclin dependent kinases . Negative_regulation HAMP PGC 23438894 2760230 At the molecular level , *suppresses* [HAMP] transcription via the interaction with hepatocyte nuclear factor 4a . Negative_regulation HAMP PGC 23438894 2760231 Our data suggest a critical *role* for in the regulation of hepatic [HAMP] expression and iron homeostasis under inflammatory circumstances . Negative_regulation HAMP TF 20956801 2375979 To investigate the *role* of in the regulation of [hepcidin] expression by these factors in vivo , we employed the hypotransferrinemic ( hpx ) mouse . Negative_regulation HAMP TNF 19008338 2016503 Regulation of liver [hepcidin] expression by alcohol in vivo does not *involve* Kupffer cell activation or signaling . Negative_regulation HAMP TNF 19008338 2016505 Our results demonstrate that alcohol induced Kupffer cell activation and signaling are not *involved* in the suppression of liver [hepcidin] expression by alcohol mediated oxidative stress in vivo . Negative_regulation HAS1 IL1B 17611197 1786711 stimulation *resulted* in induction of [HAS1] and HAS2 transcription but did not induce phenotypic differentiation or induce HA coat assembly . Negative_regulation HAS2 IL1B 17611197 1786712 stimulation *resulted* in induction of HAS1 and [HAS2] transcription but did not induce phenotypic differentiation or induce HA coat assembly . Negative_regulation HAVCR2 MAP2K6 21621846 2470510 These results suggest the regulatory *role* of in [TIM-3] transcription by human CD4+ T cells and mast cells . Negative_regulation HBEGF ADIPOQ 12138120 991574 In cultured endothelial cells , *attenuated* [HB-EGF] expression stimulated by tumor necrosis factor alpha . Negative_regulation HBEGF ANGPTL4 23443317 2781134 Furthermore , suppression of VEGFA or expression *enhanced* [HB-EGF] expression , highlighting a unique regulatory loop underlying this angiogenesis network . Negative_regulation HBEGF AREG 17986609 1826782 The observation of normal induction of uterine amphiregulin surrounding the blastocyst at the time of attachment in these conditional mutant mice suggests a compensatory *role* of for uterine loss of [HB-EGF] , preventing complete failure of pregnancy . Negative_regulation HBEGF CDC73 7713868 298105 These results suggest a potential *role* of in [HB-EGF] expression and provide evidence that this stimulation may occur through increased kappa B binding activity . Negative_regulation HBEGF CDH1 12057867 952233 In contrast , epidermal growth factor (EGF) or [heparin binding EGF-like growth factor] ( HB-EGF ) *induces* the epithelial-like to fibroblastoid conversion of A549 and H322 cell lines , slightly reduces the expression of and beta-catenin , but not alpha- and gamma-catenins , and stimulates cell motility . Negative_regulation HBEGF CTNNB1 12057867 952234 In contrast , epidermal growth factor (EGF) or [heparin binding EGF-like growth factor] ( HB-EGF ) *induces* the epithelial-like to fibroblastoid conversion of A549 and H322 cell lines , slightly reduces the expression of E-cadherin and , but not alpha- and gamma-catenins , and stimulates cell motility . Negative_regulation HBEGF CTR9 7713868 298106 These results suggest a potential *role* of in [HB-EGF] expression and provide evidence that this stimulation may occur through increased kappa B binding activity . Negative_regulation HBEGF EGF 11208719 787285 We determined the *role* of in stress induced expression of heparin binding EGF-like growth factor ( [HB-EGF] ) in a rat gastric epithelial cell line ( RGM1 cells ) . Negative_regulation HBEGF EGF 9276746 451301 Amphiregulin and [heparin binding EGF-like growth factor] ( HB-EGF ) transcripts were rapidly and markedly *induced* , whereas and TGF-alpha mRNAs were undetectable or only slightly increased . Negative_regulation HBEGF EGFR 23451083 2749373 Both telmisartan and candesartan did not inhibit TPA induced phosphorylation , and telmisartan , but not candesartan , *inhibited* TPA induced nuclear translocation of [HB-EGF-CTF] after knockdown of AT1R . Negative_regulation HBEGF ERBB4 8626392 355672 Among the EGF agonists , [HB-EGF] *induced* a low level of tyrosine phosphorylation , while BTC was as efficient as NDF in activating ErbB-4 . Negative_regulation HBEGF EREG 10681561 669411 *up-regulated* the mRNA levels of heparin binding EGF-like growth factor ( [HB-EGF] ) , amphiregulin , and TGF-alpha . Negative_regulation HBEGF GAST 14764442 1242868 stimulation *resulted* in a fivefold increase in [HB-EGF-luciferase] activity . Negative_regulation HBEGF GRAP2 11888934 920097 [HB-EGF] induction of NE differentiation was mediated by a mitogen activated protein kinase (MAPK) kinase dependent mechanism , and this process was *blocked* by MAPK signaling . Negative_regulation HBEGF GRAP2 21413023 2404923 Moreover , our data suggest that both MAPKs and ERK1/2 are *involved* together or independently in the regulation of [HB-EGF] gene expression . Negative_regulation HBEGF IGF1R 19228610 2072037 IGF-1 was the major one : its activity was abrogated by an IGF-1R inhibitor only , whereas IL-6 , HGF , or [HB-EGF] activity was *inhibited* by both and receptor-specific inhibition . Negative_regulation HBEGF JUN 12791271 1097678 Lack of prevents EGF *induced* expression of [HB-EGF] , indicating that c-jun controls formation of the epidermal leading edge through its control of an EGF receptor autocrine loop . Negative_regulation HBEGF KRT10 19120344 2042372 RA *induced* [HB-EGF] and involucrin expression in a concentration dependent manner , whereas it inhibited expression . Negative_regulation HBEGF LEO1 7713868 298109 These results suggest a potential *role* of in [HB-EGF] expression and provide evidence that this stimulation may occur through increased kappa B binding activity . Negative_regulation HBEGF LPA 17251460 1690993 The release of HB-EGF assessed by AP activity increased significantly in *response* to wounding , , or both , and the release of [HB-EGF-AP] induced by LPA was inhibited by PP2 and GM6001 . Negative_regulation HBEGF MAPK1 11888934 920098 [HB-EGF] induction of NE differentiation was mediated by a mitogen activated protein kinase (MAPK) kinase dependent mechanism , and this process was *blocked* by p38 signaling . Negative_regulation HBEGF MAPK10 11888934 920099 [HB-EGF] induction of NE differentiation was mediated by a mitogen activated protein kinase (MAPK) kinase dependent mechanism , and this process was *blocked* by p38 signaling . Negative_regulation HBEGF MAPK11 11888934 920100 [HB-EGF] induction of NE differentiation was mediated by a mitogen activated protein kinase (MAPK) kinase dependent mechanism , and this process was *blocked* by p38 signaling . Negative_regulation HBEGF MAPK12 11888934 920101 [HB-EGF] induction of NE differentiation was mediated by a mitogen activated protein kinase (MAPK) kinase dependent mechanism , and this process was *blocked* by p38 signaling . Negative_regulation HBEGF MAPK13 11888934 920102 [HB-EGF] induction of NE differentiation was mediated by a mitogen activated protein kinase (MAPK) kinase dependent mechanism , and this process was *blocked* by p38 signaling . Negative_regulation HBEGF MAPK14 11888934 920103 [HB-EGF] induction of NE differentiation was mediated by a mitogen activated protein kinase (MAPK) kinase dependent mechanism , and this process was *blocked* by p38 signaling . Negative_regulation HBEGF MAPK15 11888934 920096 [HB-EGF] induction of NE differentiation was mediated by a mitogen activated protein kinase (MAPK) kinase dependent mechanism , and this process was *blocked* by p38 signaling . Negative_regulation HBEGF MAPK3 11888934 920104 [HB-EGF] induction of NE differentiation was mediated by a mitogen activated protein kinase (MAPK) kinase dependent mechanism , and this process was *blocked* by p38 signaling . Negative_regulation HBEGF MAPK3 21413023 2404924 Moreover , our data suggest that both MAPKs p38 and are *involved* together or independently in the regulation of [HB-EGF] gene expression . Negative_regulation HBEGF MAPK4 11888934 920105 [HB-EGF] induction of NE differentiation was mediated by a mitogen activated protein kinase (MAPK) kinase dependent mechanism , and this process was *blocked* by p38 signaling . Negative_regulation HBEGF MAPK6 11888934 920106 [HB-EGF] induction of NE differentiation was mediated by a mitogen activated protein kinase (MAPK) kinase dependent mechanism , and this process was *blocked* by p38 signaling . Negative_regulation HBEGF MAPK7 11888934 920107 [HB-EGF] induction of NE differentiation was mediated by a mitogen activated protein kinase (MAPK) kinase dependent mechanism , and this process was *blocked* by p38 signaling . Negative_regulation HBEGF MAPK8 11888934 920108 [HB-EGF] induction of NE differentiation was mediated by a mitogen activated protein kinase (MAPK) kinase dependent mechanism , and this process was *blocked* by p38 signaling . Negative_regulation HBEGF MAPK9 11888934 920109 [HB-EGF] induction of NE differentiation was mediated by a mitogen activated protein kinase (MAPK) kinase dependent mechanism , and this process was *blocked* by p38 signaling . Negative_regulation HBEGF MMP1 19220217 2061626 ( ii ) growth factors : basic fibroblast growth factor (bFGF) , platelet derived growth factor , thrombopoietin , angiopoietin-2 , vascular endothelial growth factor ( VEGF ) , hepatocyte growth factor (HGF) , keratocyte growth factor , tissue *inhibitor* of metalloprotease ( TIMP ) -1 and heparin binding epithelial growth factor ( [HB-EGF] ) and ( iii ) , MMP-2 , MMP-3 , MMP-8 , MMP-9 , MMP-10 , MMP-13 , TIMP-1 and TIMP-2 . Negative_regulation HBEGF NOS1 23760291 2870594 In cultured glomerular endothelial cells , the inhibitors NG-nitro-L-arginine methyl ester ( L-NAME ) or L-N5- ( 1-iminoethyl ) ornithine *increased* [HB-EGF] protein expression . Negative_regulation HBEGF NOS2 23760291 2870595 In cultured glomerular endothelial cells , the inhibitors NG-nitro-L-arginine methyl ester ( L-NAME ) or L-N5- ( 1-iminoethyl ) ornithine *increased* [HB-EGF] protein expression . Negative_regulation HBEGF NOS3 23760291 2870596 In cultured glomerular endothelial cells , the inhibitors NG-nitro-L-arginine methyl ester ( L-NAME ) or L-N5- ( 1-iminoethyl ) ornithine *increased* [HB-EGF] protein expression . Negative_regulation HBEGF NPY6R 17251460 1690994 The release of HB-EGF assessed by AP activity increased significantly in response to wounding , LPA , or both , and the release of [HB-EGF-AP] induced by LPA was *inhibited* by and GM6001 . Negative_regulation HBEGF NRD1 16923819 1626836 These results indicate the essential *role* of in [HB-EGF] ectodomain shedding and reveal how the shedding is regulated by the modulation of sheddase activity . Negative_regulation HBEGF PAF1 7713868 298107 These results suggest a potential *role* of in [HB-EGF] expression and provide evidence that this stimulation may occur through increased kappa B binding activity . Negative_regulation HBEGF RAF1 7649477 319138 Activation of delta : ER and a conditional oncogenic form of B-Raf , delta B-RAF : ER , *resulted* in rapid and sustained induction of [HB-EGF] mRNA expression and secretion of mature HB-EGF from cells . Negative_regulation HBEGF RB1 22240916 2591941 alone mainly *reduced* the expression of [HB-EGF] , and TMPP alone mainly reduced the expression of Calm1 and Camk2b . Negative_regulation HBEGF SOD3 16753836 1571411 also *inhibited* the induction of [HB-EGF] by 12-O-tetradecanoylphorbol-13-acetate ( TPA ) in RASMC by 60 % . Negative_regulation HBEGF SP1 19201846 2033825 The is a major factor in HB-EGF production , and knockdown of Sp1 substantially *diminishes* [HB-EGF] production . Negative_regulation HBEGF VEGFA 23443317 2781133 Furthermore , suppression of or ANGPTL4 expression *enhanced* [HB-EGF] expression , highlighting a unique regulatory loop underlying this angiogenesis network . Negative_regulation HBEGF WDR61 7713868 298108 These results suggest a potential *role* of in [HB-EGF] expression and provide evidence that this stimulation may occur through increased kappa B binding activity . Negative_regulation HBP1 TP63 20523354 2339719 We investigated the relationship between the two factors : using RNAi , overexpression , chromatin immunoprecipitations and transient transfections with reporter constructs , we established that [HBP1] is directly *repressed* by . Negative_regulation HCL1 CA12 2864736 51465 Knowing the in vitro and in vivo gastric secretory effects of beta-adrenergic agonists and antagonists , as well as the *role* of in the gastric [HCl] production , we investigated the effect of some beta-adrenoceptor agonists ( isoprenaline and orciprenaline ) and antagonists ( propranolol , timolol , atenolol , pindolol , acebutolol , metoprolol , exoxprenolol ) on the purified , human red blood cell and gastric mucosa carbonic anhydrase . Negative_regulation HCL1 TNF 18651847 1967033 At 2 h , minocycline [HCl] *induced* high levels of IL-10 , TNFalpha and IFNgamma , while CHX reduced the levels of and IFNgamma . Negative_regulation HCL1 TNF 9136953 427879 The pathogenetic *role* of in [HCL] prompted us to study the potential contribution of functionally important genetic polymorphisms of the TNF gene cluster in a large group of patients with HCL . Negative_regulation HCL2 CA12 2864736 51478 Knowing the in vitro and in vivo gastric secretory effects of beta-adrenergic agonists and antagonists , as well as the *role* of in the gastric [HCl] production , we investigated the effect of some beta-adrenoceptor agonists ( isoprenaline and orciprenaline ) and antagonists ( propranolol , timolol , atenolol , pindolol , acebutolol , metoprolol , exoxprenolol ) on the purified , human red blood cell and gastric mucosa carbonic anhydrase . Negative_regulation HCL2 TNF 18651847 1967035 At 2 h , minocycline [HCl] *induced* high levels of IL-10 , TNFalpha and IFNgamma , while CHX reduced the levels of and IFNgamma . Negative_regulation HCL2 TNF 9136953 427880 The pathogenetic *role* of in [HCL] prompted us to study the potential contribution of functionally important genetic polymorphisms of the TNF gene cluster in a large group of patients with HCL . Negative_regulation HCL3 CA12 2864736 51491 Knowing the in vitro and in vivo gastric secretory effects of beta-adrenergic agonists and antagonists , as well as the *role* of in the gastric [HCl] production , we investigated the effect of some beta-adrenoceptor agonists ( isoprenaline and orciprenaline ) and antagonists ( propranolol , timolol , atenolol , pindolol , acebutolol , metoprolol , exoxprenolol ) on the purified , human red blood cell and gastric mucosa carbonic anhydrase . Negative_regulation HCL3 TNF 18651847 1967037 At 2 h , minocycline [HCl] *induced* high levels of IL-10 , TNFalpha and IFNgamma , while CHX reduced the levels of and IFNgamma . Negative_regulation HCL3 TNF 9136953 427881 The pathogenetic *role* of in [HCL] prompted us to study the potential contribution of functionally important genetic polymorphisms of the TNF gene cluster in a large group of patients with HCL . Negative_regulation HDAC1 ALOX5 12817474 1103610 Trichostatin A and structurally related [histone deacetylase] inhibitors *induce* <5-lipoxygenase> promoter activity . Negative_regulation HDAC1 CLU 20307625 2244622 We have observed earlier that [histone deacetylase (HDAC)] inhibitors can *induce* the expression of in several neuroblastoma and glioma cell lines . Negative_regulation HDAC1 FAS 19879424 2156861 Resistance to targeted death inducing molecules , tumor necrosis factor , and TRAIL , or [histone deacetylase] *inhibitors* can also be mediated by sCLU . Negative_regulation HDAC1 IFI27 19158484 2027272 Inhibition of ( Kip1 ) gene expression by PDGF *required* protein synthesis and [histone deacetylase] activity but not Akt or ERK activity . Negative_regulation HDAC1 MMP28 20144149 2236020 The present study demonstrates that expression is *induced* by [HDAC] ( histone deacetylase ) inhibitors and that this effect is mediated through the GT-box . Negative_regulation HDAC1 PLAU 12198113 997916 The [histone deacetylase] inhibitor , Trichostatin A , *induces* the expression of the gene in MDA-MB-231 cells but not in MCF-7 cells . Negative_regulation HDAC1 TGM2 18003922 1827212 *Activation* of transcription by [histone deacetylase] inhibition as a therapeutic approach for Myc oncogenesis . Negative_regulation HDAC1 TNF 7691816 230982 In addition the cytokines interleukin-1 , -6 , and *mediate* a decrease in hepatic [SAP] ( FP ) transcript levels in female hamsters but did not cause a significant elevation of SAP ( FP ) mRNA in livers of male hamsters . Negative_regulation HDAC1 TNFSF10 18701496 1950471 Here , we show that the [histone deacetylase (HDAC)] inhibitors *induce* in human breast cancer cells . Negative_regulation HDAC1 TNFSF10 19879424 2156862 Resistance to targeted death inducing molecules , tumor necrosis factor , Fas and , or [histone deacetylase] *inhibitors* can also be mediated by sCLU . Negative_regulation HDAC10 ALOX5 12817474 1103597 Trichostatin A and structurally related [histone deacetylase] inhibitors *induce* <5-lipoxygenase> promoter activity . Negative_regulation HDAC10 FAS 19879424 2156857 Resistance to targeted death inducing molecules , tumor necrosis factor , and TRAIL , or [histone deacetylase] *inhibitors* can also be mediated by sCLU . Negative_regulation HDAC10 IFI27 19158484 2027266 Inhibition of ( Kip1 ) gene expression by PDGF *required* protein synthesis and [histone deacetylase] activity but not Akt or ERK activity . Negative_regulation HDAC10 PLAU 12198113 997914 The [histone deacetylase] inhibitor , Trichostatin A , *induces* the expression of the gene in MDA-MB-231 cells but not in MCF-7 cells . Negative_regulation HDAC10 TGM2 18003922 1827210 *Activation* of transcription by [histone deacetylase] inhibition as a therapeutic approach for Myc oncogenesis . Negative_regulation HDAC10 TNFSF10 19879424 2156858 Resistance to targeted death inducing molecules , tumor necrosis factor , Fas and , or [histone deacetylase] *inhibitors* can also be mediated by sCLU . Negative_regulation HDAC11 ALOX5 12817474 1103598 Trichostatin A and structurally related [histone deacetylase] inhibitors *induce* <5-lipoxygenase> promoter activity . Negative_regulation HDAC11 FAS 19879424 2156859 Resistance to targeted death inducing molecules , tumor necrosis factor , and TRAIL , or [histone deacetylase] *inhibitors* can also be mediated by sCLU . Negative_regulation HDAC11 IFI27 19158484 2027267 Inhibition of ( Kip1 ) gene expression by PDGF *required* protein synthesis and [histone deacetylase] activity but not Akt or ERK activity . Negative_regulation HDAC11 PLAU 12198113 997915 The [histone deacetylase] inhibitor , Trichostatin A , *induces* the expression of the gene in MDA-MB-231 cells but not in MCF-7 cells . Negative_regulation HDAC11 TGM2 18003922 1827211 *Activation* of transcription by [histone deacetylase] inhibition as a therapeutic approach for Myc oncogenesis . Negative_regulation HDAC11 TNFSF10 19879424 2156860 Resistance to targeted death inducing molecules , tumor necrosis factor , Fas and , or [histone deacetylase] *inhibitors* can also be mediated by sCLU . Negative_regulation HDAC2 ALOX5 12817474 1103611 Trichostatin A and structurally related [histone deacetylase] inhibitors *induce* <5-lipoxygenase> promoter activity . Negative_regulation HDAC2 CCND1 24965412 2947487 Furthermore , Western blot analyses demonstrated that downregulated [HDAC2] expression *inhibited* the expression of , cyclin E , and cdk2 proteins but elevated the expression of p21 protein . Negative_regulation HDAC2 CLU 20307625 2244623 We have observed earlier that [histone deacetylase (HDAC)] inhibitors can *induce* the expression of in several neuroblastoma and glioma cell lines . Negative_regulation HDAC2 FAS 19879424 2156863 Resistance to targeted death inducing molecules , tumor necrosis factor , and TRAIL , or [histone deacetylase] *inhibitors* can also be mediated by sCLU . Negative_regulation HDAC2 IFI27 19158484 2027273 Inhibition of ( Kip1 ) gene expression by PDGF *required* protein synthesis and [histone deacetylase] activity but not Akt or ERK activity . Negative_regulation HDAC2 MMP28 20144149 2236021 The present study demonstrates that expression is *induced* by [HDAC] ( histone deacetylase ) inhibitors and that this effect is mediated through the GT-box . Negative_regulation HDAC2 PLAU 12198113 997917 The [histone deacetylase] inhibitor , Trichostatin A , *induces* the expression of the gene in MDA-MB-231 cells but not in MCF-7 cells . Negative_regulation HDAC2 TGM2 18003922 1827213 *Activation* of transcription by [histone deacetylase] inhibition as a therapeutic approach for Myc oncogenesis . Negative_regulation HDAC2 TNF 7691816 230983 In addition the cytokines interleukin-1 , -6 , and *mediate* a decrease in hepatic [SAP] ( FP ) transcript levels in female hamsters but did not cause a significant elevation of SAP ( FP ) mRNA in livers of male hamsters . Negative_regulation HDAC2 TNFSF10 18701496 1950472 Here , we show that the [histone deacetylase (HDAC)] inhibitors *induce* in human breast cancer cells . Negative_regulation HDAC2 TNFSF10 19879424 2156864 Resistance to targeted death inducing molecules , tumor necrosis factor , Fas and , or [histone deacetylase] *inhibitors* can also be mediated by sCLU . Negative_regulation HDAC3 ALOX5 12817474 1103612 Trichostatin A and structurally related [histone deacetylase] inhibitors *induce* <5-lipoxygenase> promoter activity . Negative_regulation HDAC3 FAS 19879424 2156865 Resistance to targeted death inducing molecules , tumor necrosis factor , and TRAIL , or [histone deacetylase] *inhibitors* can also be mediated by sCLU . Negative_regulation HDAC3 IFI27 19158484 2027274 Inhibition of ( Kip1 ) gene expression by PDGF *required* protein synthesis and [histone deacetylase] activity but not Akt or ERK activity . Negative_regulation HDAC3 PLAU 12198113 997918 The [histone deacetylase] inhibitor , Trichostatin A , *induces* the expression of the gene in MDA-MB-231 cells but not in MCF-7 cells . Negative_regulation HDAC3 TGM2 18003922 1827214 *Activation* of transcription by [histone deacetylase] inhibition as a therapeutic approach for Myc oncogenesis . Negative_regulation HDAC3 TNFSF10 19879424 2156866 Resistance to targeted death inducing molecules , tumor necrosis factor , Fas and , or [histone deacetylase] *inhibitors* can also be mediated by sCLU . Negative_regulation HDAC4 ALOX5 12817474 1103592 Trichostatin A and structurally related [histone deacetylase] inhibitors *induce* <5-lipoxygenase> promoter activity . Negative_regulation HDAC4 FAS 19879424 2156847 Resistance to targeted death inducing molecules , tumor necrosis factor , and TRAIL , or [histone deacetylase] *inhibitors* can also be mediated by sCLU . Negative_regulation HDAC4 IFI27 19158484 2027261 Inhibition of ( Kip1 ) gene expression by PDGF *required* protein synthesis and [histone deacetylase] activity but not Akt or ERK activity . Negative_regulation HDAC4 PLAU 12198113 997909 The [histone deacetylase] inhibitor , Trichostatin A , *induces* the expression of the gene in MDA-MB-231 cells but not in MCF-7 cells . Negative_regulation HDAC4 TGM2 18003922 1827205 *Activation* of transcription by [histone deacetylase] inhibition as a therapeutic approach for Myc oncogenesis . Negative_regulation HDAC4 TNFSF10 19879424 2156848 Resistance to targeted death inducing molecules , tumor necrosis factor , Fas and , or [histone deacetylase] *inhibitors* can also be mediated by sCLU . Negative_regulation HDAC5 ALOX5 12817474 1103596 Trichostatin A and structurally related [histone deacetylase] inhibitors *induce* <5-lipoxygenase> promoter activity . Negative_regulation HDAC5 FAS 19879424 2156855 Resistance to targeted death inducing molecules , tumor necrosis factor , and TRAIL , or [histone deacetylase] *inhibitors* can also be mediated by sCLU . Negative_regulation HDAC5 IFI27 19158484 2027265 Inhibition of ( Kip1 ) gene expression by PDGF *required* protein synthesis and [histone deacetylase] activity but not Akt or ERK activity . Negative_regulation HDAC5 PLAU 12198113 997913 The [histone deacetylase] inhibitor , Trichostatin A , *induces* the expression of the gene in MDA-MB-231 cells but not in MCF-7 cells . Negative_regulation HDAC5 TGM2 18003922 1827209 *Activation* of transcription by [histone deacetylase] inhibition as a therapeutic approach for Myc oncogenesis . Negative_regulation HDAC5 TNFSF10 19879424 2156856 Resistance to targeted death inducing molecules , tumor necrosis factor , Fas and , or [histone deacetylase] *inhibitors* can also be mediated by sCLU . Negative_regulation HDAC6 ALOX5 12817474 1103593 Trichostatin A and structurally related [histone deacetylase] inhibitors *induce* <5-lipoxygenase> promoter activity . Negative_regulation HDAC6 FAS 19879424 2156849 Resistance to targeted death inducing molecules , tumor necrosis factor , and TRAIL , or [histone deacetylase] *inhibitors* can also be mediated by sCLU . Negative_regulation HDAC6 IFI27 19158484 2027262 Inhibition of ( Kip1 ) gene expression by PDGF *required* protein synthesis and [histone deacetylase] activity but not Akt or ERK activity . Negative_regulation HDAC6 PLAU 12198113 997910 The [histone deacetylase] inhibitor , Trichostatin A , *induces* the expression of the gene in MDA-MB-231 cells but not in MCF-7 cells . Negative_regulation HDAC6 TGM2 18003922 1827206 *Activation* of transcription by [histone deacetylase] inhibition as a therapeutic approach for Myc oncogenesis . Negative_regulation HDAC6 TNFSF10 19879424 2156850 Resistance to targeted death inducing molecules , tumor necrosis factor , Fas and , or [histone deacetylase] *inhibitors* can also be mediated by sCLU . Negative_regulation HDAC7 ALOX5 12817474 1103595 Trichostatin A and structurally related [histone deacetylase] inhibitors *induce* <5-lipoxygenase> promoter activity . Negative_regulation HDAC7 FAS 19879424 2156853 Resistance to targeted death inducing molecules , tumor necrosis factor , and TRAIL , or [histone deacetylase] *inhibitors* can also be mediated by sCLU . Negative_regulation HDAC7 IFI27 19158484 2027264 Inhibition of ( Kip1 ) gene expression by PDGF *required* protein synthesis and [histone deacetylase] activity but not Akt or ERK activity . Negative_regulation HDAC7 PLAU 12198113 997912 The [histone deacetylase] inhibitor , Trichostatin A , *induces* the expression of the gene in MDA-MB-231 cells but not in MCF-7 cells . Negative_regulation HDAC7 TGM2 18003922 1827208 *Activation* of transcription by [histone deacetylase] inhibition as a therapeutic approach for Myc oncogenesis . Negative_regulation HDAC7 TNFSF10 19879424 2156854 Resistance to targeted death inducing molecules , tumor necrosis factor , Fas and , or [histone deacetylase] *inhibitors* can also be mediated by sCLU . Negative_regulation HDAC8 ALOX5 12817474 1103591 Trichostatin A and structurally related [histone deacetylase] inhibitors *induce* <5-lipoxygenase> promoter activity . Negative_regulation HDAC8 FAS 19879424 2156845 Resistance to targeted death inducing molecules , tumor necrosis factor , and TRAIL , or [histone deacetylase] *inhibitors* can also be mediated by sCLU . Negative_regulation HDAC8 IFI27 19158484 2027260 Inhibition of ( Kip1 ) gene expression by PDGF *required* protein synthesis and [histone deacetylase] activity but not Akt or ERK activity . Negative_regulation HDAC8 PLAU 12198113 997908 The [histone deacetylase] inhibitor , Trichostatin A , *induces* the expression of the gene in MDA-MB-231 cells but not in MCF-7 cells . Negative_regulation HDAC8 TGM2 18003922 1827204 *Activation* of transcription by [histone deacetylase] inhibition as a therapeutic approach for Myc oncogenesis . Negative_regulation HDAC8 TNFSF10 19879424 2156846 Resistance to targeted death inducing molecules , tumor necrosis factor , Fas and , or [histone deacetylase] *inhibitors* can also be mediated by sCLU . Negative_regulation HDAC9 ALOX5 12817474 1103594 Trichostatin A and structurally related [histone deacetylase] inhibitors *induce* <5-lipoxygenase> promoter activity . Negative_regulation HDAC9 FAS 19879424 2156851 Resistance to targeted death inducing molecules , tumor necrosis factor , and TRAIL , or [histone deacetylase] *inhibitors* can also be mediated by sCLU . Negative_regulation HDAC9 IFI27 19158484 2027263 Inhibition of ( Kip1 ) gene expression by PDGF *required* protein synthesis and [histone deacetylase] activity but not Akt or ERK activity . Negative_regulation HDAC9 PLAU 12198113 997911 The [histone deacetylase] inhibitor , Trichostatin A , *induces* the expression of the gene in MDA-MB-231 cells but not in MCF-7 cells . Negative_regulation HDAC9 TGM2 18003922 1827207 *Activation* of transcription by [histone deacetylase] inhibition as a therapeutic approach for Myc oncogenesis . Negative_regulation HDAC9 TNFSF10 19879424 2156852 Resistance to targeted death inducing molecules , tumor necrosis factor , Fas and , or [histone deacetylase] *inhibitors* can also be mediated by sCLU . Negative_regulation HDC IL1B 7810664 284990 ( 5 micrograms/kg iv ) completely inhibited gastrin induced acid secretion and partially *inhibited* urinary histamine excretion and fundic [HDC] activity . Negative_regulation HES1 EPHB2 19539699 2103638 Cell-cycle regulators such as cyclin dependent kinase 2 (Cdk2) , Cyclin D1 and [Hes1] *mediated* the effect of on NSCs proliferation and differentiation . Negative_regulation HES1 JAG1 22998557 2679093 mediated Notch signaling *regulates* hair cell ( HC ) production in a distinct way rather than lateral inhibition mediated by [Hes1] and Hes5 . Negative_regulation HES1 MAML3 21640102 2446196 Overexpression of by retroviral transduction in CaSki cells *resulted* in significant decreases in the mRNA levels of [Hes1] and Notch1 but had no effects on the levels of MAML1 , p53 or HPV E6/E7 . Negative_regulation HES2 F8 11395618 823340 Dextran , gelatin , and [hydroxyethyl starch (HES)] all can *induce* a specific decrease of von Willebrand factor and : c. Blood coagulation is most impaired by dextran and high molecular weight HES , both associated with increased postoperative blood loss . Negative_regulation HES2 JUN 15836676 1397700 The results suggest that in sepsis [HES] may down-regulate hepatic inflammatory mediators production and these anti-inflammatory effects may *act* through inhibition of NF-kappaB and activations . Negative_regulation HES2 JUN 15943182 1415849 The results suggest that during sepsis [HES] reduces pulmonary capillary permeability and this beneficial effect of HES may *act* through down-regulation of inflammatory mediators and suppression of NF-kappaB and activation . Negative_regulation HES2 JUN 16790644 1578636 Our results suggest that during endotoxemia [HES] may down-regulate intestinal inflammatory mediator production , and this antiinflammatory effect of HES may *act* through suppression of NF-kappaB and activations . Negative_regulation HES2 NFKB1 15836676 1397701 The results suggest that in sepsis [HES] may down-regulate hepatic inflammatory mediators production and these anti-inflammatory effects may *act* through inhibition of and AP-1 activations . Negative_regulation HES2 NFKB1 15943182 1415850 The results suggest that during sepsis [HES] reduces pulmonary capillary permeability and this beneficial effect of HES may *act* through down-regulation of inflammatory mediators and suppression of and AP-1 activation . Negative_regulation HES2 NFKB1 16790644 1578637 Our results suggest that during endotoxemia [HES] may down-regulate intestinal inflammatory mediator production , and this antiinflammatory effect of HES may *act* through suppression of and AP-1 activations . Negative_regulation HES2 RELA 15836676 1397702 The results suggest that in sepsis [HES] may down-regulate hepatic inflammatory mediators production and these anti-inflammatory effects may *act* through inhibition of and AP-1 activations . Negative_regulation HES2 RELA 15943182 1415851 The results suggest that during sepsis [HES] reduces pulmonary capillary permeability and this beneficial effect of HES may *act* through down-regulation of inflammatory mediators and suppression of and AP-1 activation . Negative_regulation HES2 RELA 16790644 1578638 Our results suggest that during endotoxemia [HES] may down-regulate intestinal inflammatory mediator production , and this antiinflammatory effect of HES may *act* through suppression of and AP-1 activations . Negative_regulation HES2 VWF 11395618 823339 Dextran , gelatin , and [hydroxyethyl starch (HES)] all can *induce* a specific decrease of and factor VIII : c. Blood coagulation is most impaired by dextran and high molecular weight HES , both associated with increased postoperative blood loss . Negative_regulation HES5 JAG1 22998557 2679088 mediated Notch signaling *regulates* hair cell ( HC ) production in a distinct way rather than lateral inhibition mediated by Hes1 and [Hes5] . Negative_regulation HEXIM1 CCND1 18757415 1956557 Increased [HEXIM1] expression in the mammary gland decreased estrogen-driven ductal morphogenesis and *inhibited* the expression of and serine 2 phosphorylated RNA polymerase II ( S2P RNAP II ) . Negative_regulation HFE TNF 12940442 1133276 Our aim was to study the *role* of and its promoter polymorphisms in the phenotypic expression of [hemochromatosis] in individuals with and without the C282Y mutation . Negative_regulation HGF CD14 8945531 400308 We therefore investigated the *role* of , an LPS receptor , in stimulation of [HGF] by LPS . Negative_regulation HGF EPHB2 18234850 1876845 VEGF , FGF2 , and [HGF] expression was significantly *reduced* by NF kappa B inhibition ( 50 % decrease ) but not or JNK inhibition . Negative_regulation HGF IL1B 15541342 1336901 IL-1alpha , , and TNF-alpha alone had minimal stimulating effects on HGF production in human dermal fibroblasts , but they strongly *inhibited* production of [HGF] induced by cholera toxin , 8-bromo-cAMP , EGF , and phorbol 12-myristate 13-acetate ( PMA ) . Negative_regulation HGF IL1B 15541342 1336903 Moreover , although the high level of [HGF] production in MRC-5 cells was *enhanced* by PMA and less markedly by , HGF production in MRC-5 cells treated with PMA plus IL-1beta was less than that in the cells treated with PMA alone . Negative_regulation HGF IL1B 15541342 1336905 In the presence of interferon (IFN)-gamma , however , cholera toxin- and 8-bromo-cAMP induced [HGF] production was not *inhibited* by . Negative_regulation HGF PLAT 10064822 593461 These results are consistent with the hypothesis that HGF/SF plays a role in the development and maintenance of both the cerebral cortex and hippocampus , and that may act as a *regulator* of [HGF/SF] activity in these structures . Negative_regulation HGF PLAT 17538930 1751776 One potential mechanism for these effects is that both tPA deficiency and *reduce* [hepatocyte growth factor (HGF)] activation and c-Met phosphorylation in the liver after BDL . Negative_regulation HGF TNF 15541342 1336897 We here report that IL-1 and , hitherto regarded as HGF inducers , potently *inhibited* [HGF] production stimulated by other HGF inducers . Negative_regulation HGF TNF 15541342 1336899 IL-1alpha , IL-1beta , and alone had minimal stimulating effects on HGF production in human dermal fibroblasts , but they strongly *inhibited* production of [HGF] induced by cholera toxin , 8-bromo-cAMP , EGF , and phorbol 12-myristate 13-acetate ( PMA ) . Negative_regulation HGF TNF 15781227 1385448 In contrast , expression of S9A-GSK3beta abolished [HGF] inhibition of basal and *stimulated* RANTES expression . Negative_regulation HGF TNF 22158049 2668168 Blocking p75 by short-hairpin RNA in cultured LLCs led to increases in *mediated* apoptosis , as well as decreases in the constitutive and TNF mediated expression of angiogenic growth factors ( VEGF , [HGF] , PLGF ) , and SDF-1a receptor CXCR4 . Negative_regulation HIF1A EPHB2 20353560 2238315 [HIF-1 alpha] protein expression in LPS stimulated THP-1 macrophages could be *blocked* by and PI3K-inhibitors , but also by the CaMKII inhibitor KN93 . Negative_regulation HIF1A FAS 15669079 1382140 Concurrently , blockade drastically activated MAPK and *promoted* further a prominent accumulation of [HIF-1alpha] in Her-2/neu overexpressors . Negative_regulation HIF1A IL1B 19490965 2149457 Additionally , IL-1beta stimulated both [HIF-1alpha] and PAI-1 in articular chondrocytes , and the mediated induction of PAI-1 was *inhibited* partly by HIF-1alpha silencing . Negative_regulation HIF1A NES 18687685 1967781 Furthermore , disruption of the ( I637A/L638A/I639A ) *restores* nuclear localization and activity of nonphosphorylated [HIF-1alpha] and renders it largely resistant to inhibition of MAPK , an effect reproduced by a phosphomimetic mutation ( S641E ) . Negative_regulation HIF1A TCN1 18639543 1954653 Further analysis revealed that strongly *inhibited* [HIF-1alpha] protein synthesis , without affecting the expression level of HIF-1alpha mRNA or degradation of HIF-1alpha protein . Negative_regulation HIF1A TLR7 20539755 2271659 In addition , we could show that stimulation *resulted* in an increase of [HIF-1alpha] controlled VEGF secretion . Negative_regulation HIF1A TNF 15604270 1346840 In tubular LLC-PK(1) cells , activation of nuclear factor kappaB (NFkappaB) by *resulted* in [HIF-1alpha] protein synthesis as determined by [ ( 35 ) S ] methionine pulse experiments . Negative_regulation HIST1H1B TNF 1292694 207802 beta [C7H15] MDP , beta C16H33 MDP , P-MDP and MDP *induced* similar level of production by murine macrophages . Negative_regulation HK2 CTGF 18433544 1900206 To explore the *role* of exogenous in the collagen III synthesis of human renal tubular epithelial cell line [HK2] in vitro . Negative_regulation HK2 IFI27 20724915 2313058 Concurrent with the late G1 arrest , we observed an overexpression of along with a decreased expression of p21 , cyclin dependent kinase 1 , cyclin dependent kinase 4 , and cyclin D. Clotrimazole *induced* the translocation of mitochondrial bound [hexokinase II] to the cytoplasm and the release of cytochrome c into the cytoplasm . Negative_regulation HLA-A FAS 16902496 1692098 Interestingly , inhibition of [HLA-A1-specific] T cell response absolutely *requires* the coexpression of and HLA-A1 antigen on the same APC . Negative_regulation HLA-DRA FAS 16699854 1560531 The expression of [MHC class II] molecules was significantly *suppressed* only by long-chain . Negative_regulation HLA-DRA ITGB2 11899433 894248 The results show that exposure to LPG did not affect the expression of major histocompatibility complex ( [MHC) class II] and B7 , but *induced* an up-regulation of CD25 , CD31 and vascular endothelial (VE)-cadherin expression and a down-regulation of expression , by LC . Negative_regulation HLA-DRA TNF 10415044 631170 Consistent with this interpretation , *blocked* IFN-gamma induced CIITA and [MHC class II] expression in mutant cells that are unresponsive to TGF-beta or IFN-beta . Negative_regulation HLA-DRA TNF 11698490 878122 In this system , addition of anti-CD44s mAbs abrogated DC-cluster formation , thereby inhibiting further maturation , as shown by a reduced production and *inhibition* of CD154 induced [MHC class II] up-regulation . Negative_regulation HLA-DRA TNF 11986225 935841 *inhibited* the IFN-gamma induced up-regulation of [MHC class II] on CVEs correlating to a decrease in the mRNA for the class II transactivator (CIITA) , whereas CIITA expression in astrocytes was unaffected . Negative_regulation HLA-DRA TNF 3139431 97381 *inhibited* the induction of [MHC class II] expression by IFN-gamma markedly , when added before or simultaneously with IFN-gamma . Negative_regulation HLA-DRA TNF 3139431 97389 The *role* of in the up-regulation as well as in the down-regulation of [MHC class II] expression in inflammatory processes is discussed . Negative_regulation HLA-DRA TNF 9730287 530269 and TGF-beta1 *inhibited* the IFN-gamma induced [MHC class II] expression . Negative_regulation HLA-DRB1 CCND1 21209944 2359474 In xenografted tumors , resveratrol upregulated the expressions of TRAIL-R1/DR4 , [TRAIL-R2/DR5] , Bax and p27 ( /KIP1 ) , and *inhibited* the expression of Bcl-2 and . Negative_regulation HLA-DRB1 DAPK1 20514412 2270798 The present findings reveal that down-regulation of endogenous expression in HHUA cells *induces* caspase dependent apoptosis , possibly through increased TRAIL , [DR4] and DR5 signaling , thereby suggesting that DAPK expression is essential for HHUA cell survival . Negative_regulation HLA-DRB1 EPHB2 19223550 2044628 Finally , small interfering RNA mediated gene silencing of JNK and *inhibited* LY30 induced increase in surface expression of [DR4] and DR5 , respectively . Negative_regulation HLA-DRB1 FAS 16699854 1560532 The expression of [MHC class II] molecules was significantly *suppressed* only by long-chain . Negative_regulation HLA-DRB1 FOXO1 21179458 2358278 The inhibition of PI3K/AKT pathway *induced* transcriptional activity resulting in induction of Bim , TRAIL , p27/KIP1 , DR4 and [DR5] , and inhibition of cyclin D1 . Negative_regulation HLA-DRB1 ITGB2 11899433 894249 The results show that exposure to LPG did not affect the expression of major histocompatibility complex ( [MHC) class II] and B7 , but *induced* an up-regulation of CD25 , CD31 and vascular endothelial (VE)-cadherin expression and a down-regulation of expression , by LC . Negative_regulation HLA-DRB1 TNF 10415044 631171 Consistent with this interpretation , *blocked* IFN-gamma induced CIITA and [MHC class II] expression in mutant cells that are unresponsive to TGF-beta or IFN-beta . Negative_regulation HLA-DRB1 TNF 11698490 878123 In this system , addition of anti-CD44s mAbs abrogated DC-cluster formation , thereby inhibiting further maturation , as shown by a reduced production and *inhibition* of CD154 induced [MHC class II] up-regulation . Negative_regulation HLA-DRB1 TNF 11986225 935842 *inhibited* the IFN-gamma induced up-regulation of [MHC class II] on CVEs correlating to a decrease in the mRNA for the class II transactivator (CIITA) , whereas CIITA expression in astrocytes was unaffected . Negative_regulation HLA-DRB1 TNF 3139431 97383 *inhibited* the induction of [MHC class II] expression by IFN-gamma markedly , when added before or simultaneously with IFN-gamma . Negative_regulation HLA-DRB1 TNF 3139431 97390 The *role* of in the up-regulation as well as in the down-regulation of [MHC class II] expression in inflammatory processes is discussed . Negative_regulation HLA-DRB1 TNF 9730287 530271 and TGF-beta1 *inhibited* the IFN-gamma induced [MHC class II] expression . Negative_regulation HLA-DRB1 TNFSF10 18992712 2015921 The engagement of with its receptor DR4 *reduced* the localization of [DR4] in caveolae and resulted in its internalization . Negative_regulation HM13 SMN2 23897586 2915991 In contrast , no difference in IMP1 protein levels was detected in whole brain lysates from SMA mice , further suggesting neuron specific *roles* of in [IMP1] expression and localization . Negative_regulation HMGB1 HES2 15133244 1245721 In addition , markedly *suppressed* plasma levels of TNF-alpha and [high mobility group box] chromosomal protein 1 ( HMGB-1 ) , decreased the number of apoptotic cells in livers and normalized the activated states of blood coagulation factors such as prothrombin time and platelet numbers caused by infection . Negative_regulation HMGB1 MAP2K6 21926646 2546838 The aim of this study was to explore the *role* of 6 ( MKK6 ) in the [HMGB1] expression in pulmonary alveolar epithelial cells induced by mechanical stretch . Negative_regulation HMGB1 TNF 18953944 1982600 induces the release and cytoplasmic translocation of HMGB1 in the peripheral blood monocytes of RA patients and thalidomide *inhibits* the release and translocation of [HMGB1] . Negative_regulation HMGB1 TNF 23623189 2795462 Our results demonstrate for the first time that NPY can directly *induce* active [HMGB1] release and cytoplasmic translocation , while the production of , IL-1ß and IL-6 is not affected . Negative_regulation HMGB2 HES2 15133244 1245728 In addition , markedly *suppressed* plasma levels of TNF-alpha and [high mobility group box] chromosomal protein 1 ( HMGB-1 ) , decreased the number of apoptotic cells in livers and normalized the activated states of blood coagulation factors such as prothrombin time and platelet numbers caused by infection . Negative_regulation HMGB3 HES2 15133244 1245735 In addition , markedly *suppressed* plasma levels of TNF-alpha and [high mobility group box] chromosomal protein 1 ( HMGB-1 ) , decreased the number of apoptotic cells in livers and normalized the activated states of blood coagulation factors such as prothrombin time and platelet numbers caused by infection . Negative_regulation HMGB4 HES2 15133244 1245714 In addition , markedly *suppressed* plasma levels of TNF-alpha and [high mobility group box] chromosomal protein 1 ( HMGB-1 ) , decreased the number of apoptotic cells in livers and normalized the activated states of blood coagulation factors such as prothrombin time and platelet numbers caused by infection . Negative_regulation HMGCR EDN2 19128228 2005517 Examples include [HMG-CoA Reductase] *inhibitors* ( `` statins '' ) , Angiotensin Converting Enzyme Inhibitors ( ACEI ) , Angiotensin Receptor blockers ( ARB ) , , certain beta blockers , and some oral hypoglycemics . Negative_regulation HMGCR IL1B 18684863 1973540 [HMG-CoA reductase] inhibition *induces* release through Rac1/PI3K/PKB dependent caspase-1 activation . Negative_regulation HMGCR TNF 15936988 1440449 Simvastatin , an [HMG-CoA reductase] inhibitor with mild inhibition of LFA-1 , *induced* the production of interleukin (IL)-18 , and interferon (IFN)-gamma in human peripheral blood mononuclear cells ( PBMC ) . Negative_regulation HMGCR TNF 7487365 290722 We assessed the antiproliferative effect of and lovastatin , an *inhibitor* of 3-hydroxy-3-methylglutaryl-coenzyme A ( [HMG-CoA) reductase] , alone and in combination , on two murine tumor cell lines . Negative_regulation HMOX1 ALOX5 24226420 2926621 Similar to 5-LO ( -/- ) mice , induction of [HO-1] , but not superoxide dismutase-2 (SOD-2) , was also observed in *response* to <5-LO> ( AA861 ) or 5-LO activating protein ( MK886 ) inhibitors . Negative_regulation HMOX1 CAPN8 21352351 2579183 Puerarin protects human umbilical vein endothelial cells against high glucose induced apoptosis by upregulating [heme oxygenase-1] and *inhibiting* activation . Negative_regulation HMOX1 EPHB2 16928811 1603906 Activation of and JNK signaling also *resulted* in the elevation of ARE activity and [HO-1] expression . Negative_regulation HMOX1 EPHB2 24302760 2899172 Tan treatment induced the phosphorylation and nuclear translocation of Nrf2 and subsequently *increased* the expression of [HO-1] , and these effects were abolished by the specific inhibitors , PD98059 and U0126 . Negative_regulation HMOX1 IL1B 18077487 1847152 Moreover , [HO-1] gene expression was *down-regulated* by and 10 mmol/l GS restored baseline values . Negative_regulation HMOX1 IL1B 9751495 533561 Cobalt-protoporphyrin IX ( CoPP ) , which increased HO expression and activity , also protected islets from the inhibitory effects of IL-1beta , even though largely *blocked* the CoPP induced increase in [HO-1] expression . Negative_regulation HMOX1 TNF 12056510 951858 did not affect TNFR-1 expression in the liver and *resulted* in time dependent up-regulation of iNOS , IL-1beta and [HO-1] . Negative_regulation HMOX1 TNF 15896346 1407974 HA pretreatment markedly *induced* [HO-1] in pulmonary epithelial cells , and ameliorated the lung injury induced by HSR as judged by the improvement of histological changes , while it decreased and inducible nitric oxide synthase gene expression , lung wet weight to dry weight ratio , and myeloperoxidase activity . Negative_regulation HMOX1 TNF 16966997 1616136 Expression of [HO-1] , TLR2 , and TLR4 in monocytes was significantly *enhanced* in patients with severe SIRS compared with that in healthy volunteers , whereas intracellular expression with peptidoglycan was significantly decreased ( p < 0.05 ) in patients compared with that in healthy volunteers . Negative_regulation HMOX1 TNF 23939022 2916014 These effects were mediated by upregulating the expression of [heme oxygenase-1 (HO-1)] and *inhibiting* the production of IL-1ß and in intestinal macrophages . Negative_regulation HMOX1 TNF 25302050 2959324 Inhibition of [HO-1] in CCC *induces* an increase in IFN-? and production in CD107a + NK-92 cells and restores NKG2D , NKp46 and NKp30 downmodulation in NK cells . Negative_regulation HNF1A IL1B 11104703 756484 Cross-talk between interleukin 1beta (IL-1beta) and IL-6 signalling pathways : selectively *inhibits* IL-6 activated signal transducer and activator of [transcription factor 1] ( STAT1 ) by a proteasome dependent mechanism . Negative_regulation HNF4A FOXO1 16885156 1613827 The insulin regulated and steroid regulatory element binding protein-1c ( SREBP-1c ) strongly *inhibited* [hepatocyte nuclear factor 4alpha] and peroxisome proliferator activated receptor gamma coactivator-1alpha trans-activation of the CYP7A1 gene . Negative_regulation HNF4A FOXO1 19740748 2158407 Coprecipitation and chromatin immunoprecipitation studies show that resveratrol enhances interaction between and HNF-4 , *reduces* binding of [HNF-4] to its own site , and promotes its recruitment to the FoxO site in a FoxO1 dependent manner . Negative_regulation HNF4A IL1B 11679969 873810 *resulted* in a decrease in [HNF-4 alpha] levels in HepG2 cells . Negative_regulation HNF4A IL1B 15550563 1380579 Furthermore , *inhibited* [HNF4alpha] gene transcription , protein expression , and binding to the CYP8B1 gene . Negative_regulation HNF4A IL1B 15550563 1380580 JNK1 phosphorylated HNF4alpha and a JNK-specific inhibitor blocked the *inhibition* of [HNF4alpha] expression . Negative_regulation HNF4A IL1B 16729332 1565809 Co-immunoprecipitation and ChIP assays revealed that and CDCA *reduced* [HNF4 alpha] bound to the CYP7A1 chromatin , and that c-Jun interacted with HNF4 alpha and blocked HNF4 alpha recruitment of PGC-1 alpha to the CYP7A1 chromatin . Negative_regulation HNF4A IL1B 16729332 1565817 In conclusion , and CDCA *inhibit* [HNF4 alpha] but induce c-Jun , which in turn blocks HNF 4 alpha recruitment of PGC-1 alpha to the CYP7A1 chromatin and results in inhibition of CYP7A1 gene transcription . Negative_regulation HNF4A IL1B 17372675 1720540 inhibits the hypoxic inducibility of the erythropoietin enhancer by *suppressing* [hepatocyte nuclear factor-4alpha] . Negative_regulation HNF4A IL1B 17372675 1720541 *inhibited* [HNF-4alpha] mRNA expression and caused proteasome dependent degradation of HNF-4alpha protein , which resulted in a strongly reduced DNA binding activity of HNF-4alpha . Negative_regulation HNF4A TNF 15349890 1292349 *inhibited* the induction of [hepatocyte nuclear factor 4alpha] induced by OSM and matrigel , suggesting that down-regulation of hepatocyte nuclear factor 4alpha expression is involved in the mechanism of suppression of hepatic maturation by TNFalpha . Negative_regulation HNF4A TNF 16771709 1599261 had no effect on the stability or the nuclear localization of HNF-4 in HepG2 cells , but *inhibited* the binding of [HNF-4] to the proximal APOC3 HRE ( hormone response element ) . Negative_regulation HNRNPF TLR7 18824534 1987726 Rather , it has been shown that helminth products such as soluble egg antigens ( SEA ; a soluble extract from Schistosoma mansoni eggs ) inhibit the activation of [DCs] in *response* to classical ligands such as lipopolysaccharide or CpG . Negative_regulation HNRNPF TLR7 23257360 2724728 Given the expansion of CD11c+ DCs during the progression of atherosclerosis and the key role of T cell activation in atherogenesis , we sought to understand the *role* of signaling in CD11c+ [DCs] in atherosclerosis . Negative_regulation HNRNPF TNF 14611814 1162831 Increasing enhanced the survival of culturing stem cells and *resulted* in a parallel increase in day 14 [DCs] . Negative_regulation HNRNPF TNF 20735407 2341625 Shikonin treated [BM-DCs] were poor stimulators of CD4 ( + ) T lymphocyte and *induced* lower levels of interleukin (IL)-4 , IL-5 , IL-13 and release by responding T-cells . Negative_regulation HNRNPH1 TLR7 18824534 1987736 Rather , it has been shown that helminth products such as soluble egg antigens ( SEA ; a soluble extract from Schistosoma mansoni eggs ) inhibit the activation of [DCs] in *response* to classical ligands such as lipopolysaccharide or CpG . Negative_regulation HNRNPH1 TLR7 23257360 2724738 Given the expansion of CD11c+ DCs during the progression of atherosclerosis and the key role of T cell activation in atherogenesis , we sought to understand the *role* of signaling in CD11c+ [DCs] in atherosclerosis . Negative_regulation HNRNPH1 TNF 14611814 1162832 Increasing enhanced the survival of culturing stem cells and *resulted* in a parallel increase in day 14 [DCs] . Negative_regulation HNRNPH1 TNF 20735407 2341628 Shikonin treated [BM-DCs] were poor stimulators of CD4 ( + ) T lymphocyte and *induced* lower levels of interleukin (IL)-4 , IL-5 , IL-13 and release by responding T-cells . Negative_regulation HNRNPK EPHB2 11231586 789572 Our results establish the *role* of in phosphorylation dependent cellular localization of [hnRNP-K] , which is required for its ability to silence mRNA translation . Negative_regulation HOXA3 CLU 16213748 1501093 Among these 30 genes we found a high proportion of genes associated with apoptotic cell death , cell proliferation and cell cycle signalling including complement lysis *inhibitor* ( ) , beta-catenin interacting protein ( ICAT ) , peroxisome proliferator activated receptor alpha ( PPARalpha ) , TNF alpha converting enzyme ( ADAM17/TACE ) , [homeo box A3] ( HOX1 ) , inositol polyphosphatase 5-phosphatase type IV ( PPI5PIV ) and inhibitor of p53 induced apoptosis alpha ( IPIA-Alpha/NM23-H6 ) . Negative_regulation HOXB2 MSH6 17875935 1818349 and Pbx1 compete for Prep1 in vitro , and p160 *inhibits* Prep1 dependent [HoxB2] expression in retinoic acid treated NT2-D1 cells . Negative_regulation HOXB2 PBX1 17875935 1818350 p160 and compete for Prep1 in vitro , and p160 *inhibits* Prep1 dependent [HoxB2] expression in retinoic acid treated NT2-D1 cells . Negative_regulation HPGD IL1B 16632868 1631289 The *induced* reduction of the expression of [15-PGDH] was shown not to be mediated by COX-2 derived products since the presence of COX-2 inhibitors did not block the attenuation of the expression of 15-PGDH . Negative_regulation HPGD TNF 16195422 1507791 The decrease in amounts of 15-PGDH in inflamed mucosa can be explained at least , in part , by *mediated* suppression of [15-PGDH] transcription . Negative_regulation HPGDS ARSA 10593965 572928 Phosphorylation of a [glutathione S-transferase-IkappaBalpha] fusion protein by cellular extracts or immunoprecipitated IKKalpha isolated from cells treated with TNFalpha is *inhibited* by <5-ASA> . Negative_regulation HPGDS ARSA 10593965 572930 Recombinant IKKalpha and IKKbeta autophosphorylation and their phosphorylation of [glutathione S-transferase-IkappaBalpha] are *inhibited* by <5-ASA> . Negative_regulation HPGDS TNF 12475390 1023616 *inhibits* [glutathione S-transferase-alpha] expression in cultured porcine Sertoli cells . Negative_regulation HPR RARB 15375546 1298019 Among the above retinoids , [4-HPR] was most efficacious in inhibiting the growth of the three cell lines and this apparently was not *dependent* on the levels of the transcriptional activation . Negative_regulation HPX TF 8262649 246879 Neither heme , protoporphyrin IX , hemoglobin , nor *blocked* the binding of [hemopexin] to whole cells , demonstrating the specificity of binding . Negative_regulation HRAS EPHB2 10978313 751953 Whereas the essential *roles* of and JNK in [Ras] signaling has been established , the contribution of p38 remains unclear . Negative_regulation HRAS EPHB2 11585923 866386 We find that unlike other receptor tyrosine kinases , *induces* a pronounced downregulation of GTP bound [Ras] and consequently of the extracellular signal regulated kinase ( ERK ) mitogen activated protein kinase (MAPK) pathway . Negative_regulation HRAS EPHB2 11874466 918774 Further evidence for differential regulation of RAS and ERK is provided by the observations that TPO , which activates RAS but not protein kinase C , does not activate , and that the inhibitor of SRC kinases PP1 *inhibits* activation of [RAS] but not ERK2 in response to thrombin . Negative_regulation HRAS EPHB2 14660603 1202128 However , when COS-1 cells were transfected with Ras complexed to CD8 , plasma membrane localization of [Ras] was unaffected by AFC , yet EGF stimulated activation was *inhibited* by AFC . Negative_regulation HRAS EPHB2 15070811 1265701 Specific IL-1 receptor antagonism and selective kinase or upstream [Ras] *inhibition* prevented these increases , whereas PKC inhibition did not . Negative_regulation HRAS EPHB2 15735740 1389710 Inhibition of either or PI3 kinase *blocked* the capacity of both activated M-Ras and activated [H-Ras] to support proliferation and viability . Negative_regulation HRAS EPHB2 16931794 1633024 This study provides direct evidence for a novel molecular mechanism by which oxidants can induce insulin resistance via S-glutathiolation of [p21ras] and dependent *inhibition* of insulin signaling . Negative_regulation HRAS EPHB2 16978937 1673653 Matrix mineralization by preosteocytic MLO-A5 cells and osteoblastic MC3T3-E1 cells was increased by either PD98059 Mek inhibitor treatment or adenovirus vector mediated dominant negative [Ras] ( Ras ( DN ) ) expression and was *suppressed* by activation by platelet derived growth factor ( PDGF ) treatment or constitutively active Mek1 ( Mek ( CA ) ) expression . Negative_regulation HRAS EPHB2 22371971 2561709 Inhibition of calcineurin further reduced the phosphorylation of and AKT ( at thr 308 ) and *inhibited* the activation of [Ras] , but inhibitors of MAPK or PI3K signaling did not affect the circadian rhythm of calcineurin activity . Negative_regulation HRAS EPHB2 22425622 2612642 DGKa knockdown impaired MEK and phosphorylation , but did not *inhibit* [Ras] activation in HCC cells . Negative_regulation HRAS EPHB2 24576830 2929522 In these cell lines , the MEK inhibitor PD0325901 inhibited phosphorylation , but also relieved feedback *inhibition* of [RAS] , resulting in induction of pMEK and a rapid rebound in ERK signaling . Negative_regulation HRAS FHL1 23456229 2781795 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Negative_regulation HRAS MAP2K6 10978313 751968 Moreover , the constitutive p38 activator also *suppressed* [Ras] activity in a p38 dependent manner whereas arsenite , a potent chemical inducer of p38 , inhibited proliferation only in a tumor cell line that required Ras activity . Negative_regulation HRAS MAP2K6 12364324 1019052 GLP1 stimulated activation of Erk is blocked by inhibitors of , but GLP1 does not *induce* the activation of A-Raf , B-Raf , C-Raf , or [Ras] . Negative_regulation HRAS MAP2K6 12411397 1010721 PE and ET-1 do not activate protein kinase B but *stimulate* [Ras] and Erk , and their ability to activate protein synthesis was blocked by inhibition of Ras or and by rapamycin , which inhibits mTOR ( mammalian target of rapamycin ) . Negative_regulation HRAS MAP2K6 22425622 2612648 DGKa knockdown impaired and ERK phosphorylation , but did not *inhibit* [Ras] activation in HCC cells . Negative_regulation HRAS MUC16 17268066 1691585 Expression of [RAS1mRNA] in C. albicans was *inhibited* by . Negative_regulation HRAS PLAU 16826166 1638591 Functional blockade of or inhibition of p70S6 kinase , but not *inhibition* of [Ras/ERK] signaling , suppresses this GM3 induced stimulation of cell proliferation . Negative_regulation HRAS TNF 12526099 1028244 These results indicate that [RAs] attenuate iNOS expression reversibly in TNF stimulated 3T3-L1 adipocytes , and that the induced LPL suppression is not the *result* of NO overproduction . Negative_regulation HRAS TNF 21938476 2532755 With 4-MC pretreatment to hyperglycemic rats the following results were noted : ( i ) Decrease in pancreatic NGF level was blocked , ( ii ) Increase in pancreatic level and the number of TNF-a ( + ) beta cell in the islets were prevented , ( iii ) *Increase* in the number of ß cell synthhesized apoptotic [Ras] effectors that RASSF1 and NORE1 was blocked , ( iv ) While pancreatic lipid peroxidation level decreased , antioxidant molecule glutathione and antioxidant enzymes glutathione peroxidase , catalase and superoxide dismutase activities increased , ( v ) Pancreatic caspase-3 activity and the number of cleaved caspase-3 ( + ) ß cells were decreased . Negative_regulation HRH1 IL1B 11282781 799239 An inhibitor of NF-kappaB activation , pyrrolidine dithiocarbamate , and a p38 MAPK inhibitor , blocked the *induced* [H(1)R] desensitization , whereas anisomycin , an SAPK/JNK and p38 MAPK activator , mimicked the effect of IL-1beta . Negative_regulation HRH1 NFKB1 11282781 799240 An inhibitor of activation , pyrrolidine dithiocarbamate , and a p38 MAPK inhibitor , *blocked* the IL-1beta induced [H(1)R] desensitization , whereas anisomycin , an SAPK/JNK and p38 MAPK activator , mimicked the effect of IL-1beta . Negative_regulation HRH1 RELA 11282781 799241 An inhibitor of activation , pyrrolidine dithiocarbamate , and a p38 MAPK inhibitor , *blocked* the IL-1beta induced [H(1)R] desensitization , whereas anisomycin , an SAPK/JNK and p38 MAPK activator , mimicked the effect of IL-1beta . Negative_regulation HRH1 TNFRSF14 10391141 626223 Northern blot and sequencing analysis demonstrated that the expression of the human [histamine H1 receptor] gene was differentially *repressed* by the orphan receptor . Negative_regulation HRH1 VDR 17547532 1784215 RT-PCR , electromotility shift , siRNA inhibition assays , and chromatin immunoprecipitation assays were used to analyze the *role* of in activation of DPT and [HRH1] during differentiation . Negative_regulation HRH1 VDR 17547532 1784223 Overexpression of in MG-63 osteosarcoma cells *induced* the expression of [HRH1] and DPT . Negative_regulation HSD11B2 ANGPT2 12911547 1122120 Cortisol enhanced AT1 receptor mRNA expression when the [11beta-HSD2] activity was *reduced* either by or by glycyrrhetinic acid , an 11beta-HSD2 inhibitor . Negative_regulation HSD11B2 CA2 11350048 814594 Collectively , these results demonstrate for the first time that *inhibits* human placental [11beta-HSD2] activity by a post-translational mechanism not involving substrate or cofactor binding . Negative_regulation HSD11B2 CBX1 10599992 573802 To investigate the effects of placental 11beta-HSD2 inhibition on glucose metabolism and the 11beta-HSD system in adult offspring , pregnant rats were treated with daily injections of , an *inhibitor* of [11beta-HSD] . Negative_regulation HSD11B2 CBX1 11481269 843612 IOP was measured in eight male volunteers before and after oral ingestion of , a known *inhibitor* of [11 beta-HSD] . Negative_regulation HSD11B2 CBX1 12621120 1079868 The pups were treated with , an *inhibitor* of [11betaHSD] , for 10 d during the suckling ( days 8-18 ) or weaning period ( days 14-24 or days 20-30 ) , and we determined the parameters of intestinal growth and activities of sucrase , alkaline phosphatase , and Na , K-ATPase . Negative_regulation HSD11B2 CBX1 12881590 1116238 Randomized , placebo controlled studies of healthy volunteers and patients with ocular hypertension ( OHT , raised IOP but no optic neuropathy ) assessed the effect of oral carbenoxolone ( , an *inhibitor* of [11beta-HSD] ) on IOP . Negative_regulation HSD11B2 CBX1 18524870 1939833 The reduction of hepatic GR gene expression was accompanied by induced *inhibition* of both [11beta-HSD1] and H6PDH activity and mRNA in the liver . Negative_regulation HSD11B2 CBX1 19456256 2084623 , an [11beta-HSD1] *inhibitor* , has been shown to reduce IOP in healthy volunteers and patients with ocular hypertension ( OHT ) . Negative_regulation HSD11B2 CBX1 9191983 437682 A single 1.8 [11 beta-HSD] 1 transcript was detected , and its abundance was *reduced* by . Negative_regulation HSD11B2 CBX2 10599992 573803 To investigate the effects of placental 11beta-HSD2 inhibition on glucose metabolism and the 11beta-HSD system in adult offspring , pregnant rats were treated with daily injections of , an *inhibitor* of [11beta-HSD] . Negative_regulation HSD11B2 CBX2 11481269 843613 IOP was measured in eight male volunteers before and after oral ingestion of , a known *inhibitor* of [11 beta-HSD] . Negative_regulation HSD11B2 CBX2 12621120 1079869 The pups were treated with , an *inhibitor* of [11betaHSD] , for 10 d during the suckling ( days 8-18 ) or weaning period ( days 14-24 or days 20-30 ) , and we determined the parameters of intestinal growth and activities of sucrase , alkaline phosphatase , and Na , K-ATPase . Negative_regulation HSD11B2 CBX2 12881590 1116239 Randomized , placebo controlled studies of healthy volunteers and patients with ocular hypertension ( OHT , raised IOP but no optic neuropathy ) assessed the effect of oral carbenoxolone ( , an *inhibitor* of [11beta-HSD] ) on IOP . Negative_regulation HSD11B2 CBX2 18524870 1939834 The reduction of hepatic GR gene expression was accompanied by *induced* inhibition of both [11beta-HSD1] and H6PDH activity and mRNA in the liver . Negative_regulation HSD11B2 CBX2 19456256 2084624 , an [11beta-HSD1] *inhibitor* , has been shown to reduce IOP in healthy volunteers and patients with ocular hypertension ( OHT ) . Negative_regulation HSD11B2 CBX2 9191983 437683 A single 1.8 [11 beta-HSD] 1 transcript was detected , and its abundance was *reduced* by . Negative_regulation HSD11B2 CBX3 10599992 573804 To investigate the effects of placental 11beta-HSD2 inhibition on glucose metabolism and the 11beta-HSD system in adult offspring , pregnant rats were treated with daily injections of , an *inhibitor* of [11beta-HSD] . Negative_regulation HSD11B2 CBX3 11481269 843614 IOP was measured in eight male volunteers before and after oral ingestion of , a known *inhibitor* of [11 beta-HSD] . Negative_regulation HSD11B2 CBX3 12621120 1079870 The pups were treated with , an *inhibitor* of [11betaHSD] , for 10 d during the suckling ( days 8-18 ) or weaning period ( days 14-24 or days 20-30 ) , and we determined the parameters of intestinal growth and activities of sucrase , alkaline phosphatase , and Na , K-ATPase . Negative_regulation HSD11B2 CBX3 12881590 1116240 Randomized , placebo controlled studies of healthy volunteers and patients with ocular hypertension ( OHT , raised IOP but no optic neuropathy ) assessed the effect of oral carbenoxolone ( , an *inhibitor* of [11beta-HSD] ) on IOP . Negative_regulation HSD11B2 CBX3 18524870 1939835 The reduction of hepatic GR gene expression was accompanied by induced *inhibition* of both [11beta-HSD1] and H6PDH activity and mRNA in the liver . Negative_regulation HSD11B2 CBX3 19456256 2084625 , an [11beta-HSD1] *inhibitor* , has been shown to reduce IOP in healthy volunteers and patients with ocular hypertension ( OHT ) . Negative_regulation HSD11B2 CBX3 9191983 437684 A single 1.8 [11 beta-HSD] 1 transcript was detected , and its abundance was *reduced* by . Negative_regulation HSD11B2 CBX4 10599992 573805 To investigate the effects of placental 11beta-HSD2 inhibition on glucose metabolism and the 11beta-HSD system in adult offspring , pregnant rats were treated with daily injections of , an *inhibitor* of [11beta-HSD] . Negative_regulation HSD11B2 CBX4 11481269 843615 IOP was measured in eight male volunteers before and after oral ingestion of , a known *inhibitor* of [11 beta-HSD] . Negative_regulation HSD11B2 CBX4 12621120 1079871 The pups were treated with , an *inhibitor* of [11betaHSD] , for 10 d during the suckling ( days 8-18 ) or weaning period ( days 14-24 or days 20-30 ) , and we determined the parameters of intestinal growth and activities of sucrase , alkaline phosphatase , and Na , K-ATPase . Negative_regulation HSD11B2 CBX4 12881590 1116241 Randomized , placebo controlled studies of healthy volunteers and patients with ocular hypertension ( OHT , raised IOP but no optic neuropathy ) assessed the effect of oral carbenoxolone ( , an *inhibitor* of [11beta-HSD] ) on IOP . Negative_regulation HSD11B2 CBX4 18524870 1939836 The reduction of hepatic GR gene expression was accompanied by *induced* inhibition of both [11beta-HSD1] and H6PDH activity and mRNA in the liver . Negative_regulation HSD11B2 CBX4 19456256 2084626 , an [11beta-HSD1] *inhibitor* , has been shown to reduce IOP in healthy volunteers and patients with ocular hypertension ( OHT ) . Negative_regulation HSD11B2 CBX4 9191983 437685 A single 1.8 [11 beta-HSD] 1 transcript was detected , and its abundance was *reduced* by . Negative_regulation HSD11B2 CBX5 10599992 573806 To investigate the effects of placental 11beta-HSD2 inhibition on glucose metabolism and the 11beta-HSD system in adult offspring , pregnant rats were treated with daily injections of , an *inhibitor* of [11beta-HSD] . Negative_regulation HSD11B2 CBX5 11481269 843616 IOP was measured in eight male volunteers before and after oral ingestion of , a known *inhibitor* of [11 beta-HSD] . Negative_regulation HSD11B2 CBX5 12621120 1079872 The pups were treated with , an *inhibitor* of [11betaHSD] , for 10 d during the suckling ( days 8-18 ) or weaning period ( days 14-24 or days 20-30 ) , and we determined the parameters of intestinal growth and activities of sucrase , alkaline phosphatase , and Na , K-ATPase . Negative_regulation HSD11B2 CBX5 12881590 1116242 Randomized , placebo controlled studies of healthy volunteers and patients with ocular hypertension ( OHT , raised IOP but no optic neuropathy ) assessed the effect of oral carbenoxolone ( , an *inhibitor* of [11beta-HSD] ) on IOP . Negative_regulation HSD11B2 CBX5 18524870 1939837 The reduction of hepatic GR gene expression was accompanied by induced *inhibition* of both [11beta-HSD1] and H6PDH activity and mRNA in the liver . Negative_regulation HSD11B2 CBX5 19456256 2084627 , an [11beta-HSD1] *inhibitor* , has been shown to reduce IOP in healthy volunteers and patients with ocular hypertension ( OHT ) . Negative_regulation HSD11B2 CBX5 9191983 437686 A single 1.8 [11 beta-HSD] 1 transcript was detected , and its abundance was *reduced* by . Negative_regulation HSD11B2 CBX6 10599992 573807 To investigate the effects of placental 11beta-HSD2 inhibition on glucose metabolism and the 11beta-HSD system in adult offspring , pregnant rats were treated with daily injections of , an *inhibitor* of [11beta-HSD] . Negative_regulation HSD11B2 CBX6 11481269 843617 IOP was measured in eight male volunteers before and after oral ingestion of , a known *inhibitor* of [11 beta-HSD] . Negative_regulation HSD11B2 CBX6 12621120 1079873 The pups were treated with , an *inhibitor* of [11betaHSD] , for 10 d during the suckling ( days 8-18 ) or weaning period ( days 14-24 or days 20-30 ) , and we determined the parameters of intestinal growth and activities of sucrase , alkaline phosphatase , and Na , K-ATPase . Negative_regulation HSD11B2 CBX6 12881590 1116243 Randomized , placebo controlled studies of healthy volunteers and patients with ocular hypertension ( OHT , raised IOP but no optic neuropathy ) assessed the effect of oral carbenoxolone ( , an *inhibitor* of [11beta-HSD] ) on IOP . Negative_regulation HSD11B2 CBX6 18524870 1939838 The reduction of hepatic GR gene expression was accompanied by *induced* inhibition of both [11beta-HSD1] and H6PDH activity and mRNA in the liver . Negative_regulation HSD11B2 CBX6 19456256 2084628 , an [11beta-HSD1] *inhibitor* , has been shown to reduce IOP in healthy volunteers and patients with ocular hypertension ( OHT ) . Negative_regulation HSD11B2 CBX6 9191983 437687 A single 1.8 [11 beta-HSD] 1 transcript was detected , and its abundance was *reduced* by . Negative_regulation HSD11B2 CBX7 10599992 573808 To investigate the effects of placental 11beta-HSD2 inhibition on glucose metabolism and the 11beta-HSD system in adult offspring , pregnant rats were treated with daily injections of , an *inhibitor* of [11beta-HSD] . Negative_regulation HSD11B2 CBX7 11481269 843618 IOP was measured in eight male volunteers before and after oral ingestion of , a known *inhibitor* of [11 beta-HSD] . Negative_regulation HSD11B2 CBX7 12621120 1079874 The pups were treated with , an *inhibitor* of [11betaHSD] , for 10 d during the suckling ( days 8-18 ) or weaning period ( days 14-24 or days 20-30 ) , and we determined the parameters of intestinal growth and activities of sucrase , alkaline phosphatase , and Na , K-ATPase . Negative_regulation HSD11B2 CBX7 12881590 1116244 Randomized , placebo controlled studies of healthy volunteers and patients with ocular hypertension ( OHT , raised IOP but no optic neuropathy ) assessed the effect of oral carbenoxolone ( , an *inhibitor* of [11beta-HSD] ) on IOP . Negative_regulation HSD11B2 CBX7 18524870 1939839 The reduction of hepatic GR gene expression was accompanied by induced *inhibition* of both [11beta-HSD1] and H6PDH activity and mRNA in the liver . Negative_regulation HSD11B2 CBX7 19456256 2084629 , an [11beta-HSD1] *inhibitor* , has been shown to reduce IOP in healthy volunteers and patients with ocular hypertension ( OHT ) . Negative_regulation HSD11B2 CBX7 9191983 437688 A single 1.8 [11 beta-HSD] 1 transcript was detected , and its abundance was *reduced* by . Negative_regulation HSD11B2 CBX8 10599992 573809 To investigate the effects of placental 11beta-HSD2 inhibition on glucose metabolism and the 11beta-HSD system in adult offspring , pregnant rats were treated with daily injections of , an *inhibitor* of [11beta-HSD] . Negative_regulation HSD11B2 CBX8 11481269 843619 IOP was measured in eight male volunteers before and after oral ingestion of , a known *inhibitor* of [11 beta-HSD] . Negative_regulation HSD11B2 CBX8 12621120 1079875 The pups were treated with , an *inhibitor* of [11betaHSD] , for 10 d during the suckling ( days 8-18 ) or weaning period ( days 14-24 or days 20-30 ) , and we determined the parameters of intestinal growth and activities of sucrase , alkaline phosphatase , and Na , K-ATPase . Negative_regulation HSD11B2 CBX8 12881590 1116245 Randomized , placebo controlled studies of healthy volunteers and patients with ocular hypertension ( OHT , raised IOP but no optic neuropathy ) assessed the effect of oral carbenoxolone ( , an *inhibitor* of [11beta-HSD] ) on IOP . Negative_regulation HSD11B2 CBX8 18524870 1939840 The reduction of hepatic GR gene expression was accompanied by induced *inhibition* of both [11beta-HSD1] and H6PDH activity and mRNA in the liver . Negative_regulation HSD11B2 CBX8 19456256 2084630 , an [11beta-HSD1] *inhibitor* , has been shown to reduce IOP in healthy volunteers and patients with ocular hypertension ( OHT ) . Negative_regulation HSD11B2 CBX8 9191983 437689 A single 1.8 [11 beta-HSD] 1 transcript was detected , and its abundance was *reduced* by . Negative_regulation HSD11B2 CDCA2 10462366 639980 dose-dependently *inhibited* [11beta-HSD2] in CCT with a Ki of 19.9 micromol/L . Negative_regulation HSD11B2 CDCA3 10462366 639981 dose-dependently *inhibited* [11beta-HSD2] in CCT with a Ki of 19.9 micromol/L . Negative_regulation HSD11B2 CDCA4 10462366 639982 dose-dependently *inhibited* [11beta-HSD2] in CCT with a Ki of 19.9 micromol/L . Negative_regulation HSD11B2 CDCA5 10462366 639983 dose-dependently *inhibited* [11beta-HSD2] in CCT with a Ki of 19.9 micromol/L . Negative_regulation HSD11B2 CDCA7 10462366 639984 dose-dependently *inhibited* [11beta-HSD2] in CCT with a Ki of 19.9 micromol/L . Negative_regulation HSD11B2 CDCA8 10462366 639985 dose-dependently *inhibited* [11beta-HSD2] in CCT with a Ki of 19.9 micromol/L . Negative_regulation HSD11B2 CEBPA 10906322 730782 Here we demonstrate that is a potent activator of the 11beta-HSD1 gene in hepatoma cells and that mice deficient in C/EBPalpha have *reduced* hepatic [11beta-HSD1] expression . Negative_regulation HSD11B2 CRH 12519881 1047752 *down-regulated* [11 beta-HSD-1] activity with maximal effect at 10 ( -9 ) M ( 65 +/- 10 % of control ; Negative_regulation HSD11B2 CRH 22971074 2693529 We hypothesized that might attenuate syncytialisation , induce leptin , and *reduce* [11beta-HSD2] expression in primary villous trophoblasts , which are known features of IUGR . Negative_regulation HSD11B2 HSD17B4 19786001 2183824 Of the phthalate diesters we tested , dipropyl phthalate ( DPrP ) and significantly *inhibited* both human and rat [11beta-HSD2] activities . Negative_regulation HSD11B2 IGF1 11196447 762012 *caused* a dose dependant inhibition of [11beta-HSD1] activity in both subcutaneous and omental stromal cells . Negative_regulation HSD11B2 IL1B 15979541 1424659 In placental trophoblast , TNF-alpha and *down-regulated* [11beta-HSD2] mRNA expression and activity ( both P < .05 ) . Negative_regulation HSD11B2 INS 18467433 1938866 Our main in vitro findings are 1 ) stimulated whereas dexamethasone *inhibited* [11beta-HSD1] activity and expression in a time- and concentration dependent manner ; Negative_regulation HSD11B2 INS 8699933 371049 Dex stimulates and GH and *inhibit* [11 beta-HSD] activity in primary cultures of rat hepatocytes . Negative_regulation HSD11B2 LEPR 12765951 1094136 In contrast , leptin did not influence 11beta-HSD1 expression in primary hepatocytes from db/db mice , indicating that leptin regulation of [11beta-HSD1] expression is probably *mediated* by the functional . Negative_regulation HSD11B2 MAPK3 23966319 2850441 We showed that inhibition of with the pharmacological inhibitor U0126 *led* to a 3-fold increase in [11beta-HSD2] activity , protein , and mRNA in primary human placental trophoblast cells . Negative_regulation HSD11B2 PPARG 11278270 802412 Furthermore , whereas regulation of PPARgamma-inducible genes such as phosphoenolpyruvate carboxykinase was maintained when cellular protein synthesis was abrogated , agonist *inhibition* of [11beta-HSD-1] and leptin gene expression was ablated , thereby supporting the conclusion that PPARgamma affects the down-regulation of 11beta-HSD-1 indirectly . Negative_regulation HSD11B2 SNAP25 9348222 460635 Both SNP ( 1-400 microM ) and ( 1 mM ) *inhibited* placental [11 beta-HSD] type 2 oxidase activity but not type 1 reductase activity either in placental or chorionic cells . Negative_regulation HSD11B2 STAR 19815848 2148748 The expression of GR and [11beta-HSD1] was significantly *increased* , with an associated decrease in expression of . Negative_regulation HSD11B2 STAT5A 18378698 1907002 The JAK/STAT inhibitor , as well as expression of dominant negative , *impairs* hormone induction of [11beta-HSD2] . Negative_regulation HSD11B2 TGM7 14697232 1195302 We conclude that 11beta-HSD-1 expression and activity are increased in islets of diabetic , but not prediabetic ZDF rats , and that *prevents* both the increase in [11beta-HSD-1] and the diabetes . Negative_regulation HSD11B2 TNF 15979541 1424658 In placental trophoblast , and IL-1beta *down-regulated* [11beta-HSD2] mRNA expression and activity ( both P < .05 ) . Negative_regulation HSD11B2 TNF 16272800 1479538 Likewise , *inhibited* both activity and mRNA expression of [11beta-HSD2] . Negative_regulation HSD11B2 TNF 19153071 2079193 *reduces* the gene expression of [11beta-hydroxysteroid dehydrogenase (HSD) 2] , an inactivator of GCs , and may enhance GC activity . Negative_regulation HSD3B1 TNF 19501915 2103006 also significantly *inhibited* expression of hCG , [HSD3B1] and CYP19 genes , and stimulated CYP24A1 gene expression . Negative_regulation HSF1 EPHB2 10747973 698212 We have previously shown that the mitogen activated protein kinase phosphorylates and *suppresses* [HSF-1-driven] transcription . Negative_regulation HSF1 FAS 10224227 610077 Activation of *inhibits* heat induced activation of [HSF1] and up-regulation of hsp70 . Negative_regulation HSF1 FAS 10224227 610078 Induction of mediated signaling was *followed* by a rapid decrease in [HSF1-DNA] binding and inducible hsp70 expression . Negative_regulation HSF1 FAS 10897390 711855 Induction of mediated signalling was *followed* by a rapid decrease of [HSF1] DNA binding and inducible hsp70 expression . Negative_regulation HSF1 IL1B 2506062 117113 Furthermore the addition of recombinant to day-2 PMCM *prevented* the expression of [C4-HSF] activity . Negative_regulation HSF1 TNF 14502236 1144495 *caused* transient downregulation of [HSF1] activation and hsp70 synthesis , leading to increased sensitivity to heat induced apoptosis . Negative_regulation HSF2 IL1B 2506062 117114 Furthermore the addition of recombinant to day-2 PMCM *prevented* the expression of [C4-HSF] activity . Negative_regulation HSF4 IL1B 2506062 117115 Furthermore the addition of recombinant to day-2 PMCM *prevented* the expression of [C4-HSF] activity . Negative_regulation HSF5 IL1B 2506062 117112 Furthermore the addition of recombinant to day-2 PMCM *prevented* the expression of [C4-HSF] activity . Negative_regulation HSP90AA1 EPHB2 12223143 987669 HRT , VCR , and Vp16 could inhibit cell proliferation ( 0.28 % 0.08 % , 0.25 % 0.16 % , 0.24 % 0.11 % ) , induce apoptosis ( 21.12 % , 28.83 % , 12.30 % ) , *inhibit* [telomerase] activity , and down-regulate the protein expression of phosphorylated . Negative_regulation HSP90AA1 EPHB2 12674761 1030445 The results showed that HRT , VCR and Vp16 could inhibit cell proliferation , induce apoptosis , *inhibit* [telomerase] activity and down-regulate the protein expression of phosphorylated . Negative_regulation HSP90AA1 S100B 23522085 2803985 In vitro binding studies showed that S100A1 , S100A2 , S100A6 , and S100P directly interacted with FKBP8/FKBP38 in a Ca ( 2+ ) -dependent manner and *inhibited* the [FKBP8/FKBP38-Hsp90] and FKBP8/FKBP38-NS5A interactions . Negative_regulation HSP90AA1 TNFSF10 23358473 2758704 In recent years , studies have shown that therapeutic agents such as metformin , salinomycin , DECA-14 , rapamycin , oncostatin M (OSM) , some natural compounds , oncolytic viruses , microRNAs , cell signaling pathway inhibitors , TNF related apoptosis inducing ligand ( ) , interferon ( IFN ) , [telomerase] *inhibitors* , all-trans retinoic acid ( ATRA ) and monoclonal antibodies can suppress the self-renewal of CSCs in vitro and in vivo . Negative_regulation HSP90AA1 ZFP57 20145034 2214674 The *repression* of [telomerase] expression by artificial targeting the promoter region of the hTERT presents a new promising strategy for inhibiting the growth of human cancer cells . Negative_regulation HSP90AB1 CAPN8 12824289 1113584 Immunoprecipitation studies revealed that glucose induces loss of NO via a *dependent* decrease in the association of [hsp90] with endothelial nitric oxide synthase . Negative_regulation HSP90AB1 TFPI2 10751404 698714 Mutation of Glu-651 and Asp-653 did not affect binding of FKBP52 or but *inhibited* both Hop binding and [hsp90] chaperone activity . Negative_regulation HSPA5 CD14 14516777 1147172 These data demonstrate *dependent* and tissue-specific regulation of the [Grp78] expression after burn injury . Negative_regulation HSPA5 EPHB2 17942905 1814129 Inhibition of also *resulted* in down-regulation of [GRP78] , which was physically associated with caspase-4 , before and after treatment with tunicamycin or thapsigargin . Negative_regulation HSPA5 MAP2K6 12076252 984345 We show here that constitutively active 6 , a selective p38 MAPK activator , *enhances* the ability of the nuclear form of ATF6 to transactivate the [grp78] promoter . Negative_regulation HSPA5 MAP2K6 17942905 1814135 Inhibition of also *resulted* in down-regulation of [GRP78] , which was physically associated with caspase-4 , before and after treatment with tunicamycin or thapsigargin . Negative_regulation HSPA5 PLAT 2460739 98587 The expression of variant *resulted* in elevated levels of [GRP78] and its stable association with tPA . Negative_regulation HSPB1 IL1B 18950704 2014397 On the other hand , stimulation reduces endogenous HSP27/TRAF6 association , but *inhibiting* [HSP27] phosphorylation by using SB202190 , an inhibitor of p38 , and MAPKAPK2 RNAi increases HSP27/TRAF6 association and thereby enhances TRAF6 ubiquitination , IKK phosphorylation as well as NF-small ka , CyrillicB activation . Negative_regulation HSPB1 TNF 12694807 1080918 The [HSP27] accumulation *induced* by was significantly suppressed by 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) or 4- ( 4-fluorophenyl ) -2- ( 4-nitrophenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( PD169316 ) ; Negative_regulation HSPB1 TNF 17069861 1654796 These results indicate that *reduces* [HSP27] in PBMCs through PKC activation . Negative_regulation HSPB1 TNF 17373661 1741395 *prevented* the upregulation of [Hsp27] induced by bortezomib , which may contribute to enhanced ER stress . Negative_regulation HSPB1 TNF 18054561 1833347 In young adult mouse colonic epithelial cells , *inhibited* heat induction of [Hsp25/27] and Hsp70 , an effect not associated with changes in iHsp messenger RNA or protein half-lives but caused by suppressed de novo iHsp synthesis . Negative_regulation HSPB3 PLAU 17121915 1652264 Antimetastatic activity of insulin-like growth factor binding [protein-3] in lung cancer is *mediated* by insulin-like growth factor independent inhibition . Negative_regulation HSPD1 TNF 21192280 2414244 *resulted* in an increase in [HS protein (HSP) 60] , compared with untreated cells , those receiving HS/TNF , or TNF alone . Negative_regulation HSPD1 TNF 23620217 2778785 Furthermore , the enhanced expression of [HSP60] was reduced and the LPS induced release of and HSP60 were *inhibited* . Negative_regulation HSPG2 FAS 11007187 735349 We have previously reported that cross linking *resulted* in the activation of phosphatidylcholine-specific phospholipase C ( [PC-PLC] ) and the subsequent activation of protein kinase C ( PKC ) and phospholipase D (PLD) in A20 cells . Negative_regulation HSPG2 FAS 8846779 338006 Activation of a phosphatidylcholine-specific phospholipase C ( [PC-PLC] ) was also *detected* which appeared to be a requirement for subsequent acidic sphingomyelinase (aSMase) activation , since PC-PLC inhibitor D609 blocked Fas/APO-1 induced aSMase activation , but not induced neutral sphingomyelinase (nSMase) activation . Negative_regulation HSPG2 IL1B 16436473 1554456 Stimulation of rat aortic VSM cells with *activated* [PLC-gamma] and pharmacological inhibition of PLC attenuated IL-1beta induced ERK1/2 activation and subsequent iNOS expression . Negative_regulation HSPG2 IL1B 18260825 1895994 An IKK2-specific inhibitor or effective siRNA prevented *induced* inhibition of acetylcholine stimulated [PLC-beta] ( phopsholipase C-beta ) activation . Negative_regulation HSPG2 NT5E 7595513 330486 BDNF and also induced an autophosphorylation of TrkB receptors and subsequently *resulted* in a phosphorylation and binding of [phospholipase C-gamma (PLC-gamma)] and SH2 containing sequence to the autophosphorylated TrkB receptors . Negative_regulation HSPG2 TNF 8134404 251724 One day after treatment with 125 micrograms TCDD/kg , *resulted* in 70 , 27 , 33 and 21 % decreases in DNA-SSB , mitochondrial and microsomal lipid peroxidation and [PLC] activation , respectively , relative to TCDD treated mice . Negative_regulation HSPG2 TNF 9414418 408185 Inhibition of *induced* [PC-PLC] activation , however , seemed to be regulated at a post-receptor level as PLC inhibition and receptor occupancy did not correlate . Negative_regulation HSPG2 TNF 9882452 584155 However , did *cause* a moderate decrease in phosphatidylinositol 4,5-bisphosphate ( PIP2 ) -specific [phospholipase C (PLC)] activity in 3T3-L1 adipocytes . Negative_regulation HTR1B SLC6A2 22401777 2587689 Conventional antidepressant properties for dextromethorphan and dextrorphan include 5HTT and *inhibition* , s ( 1 ) stimulation , NMDA and PCP antagonism , and possible serotonin [5HT1b/d] receptor stimulation . Negative_regulation HTR2B EPHB2 20870034 2343048 In conclusion , KMUP-1 inhibits MCT induced PA proliferation by binding to 5-HT(2A) , 5-HT(2B) and 5-HT(2C) receptors , increasing endothelial [eNOS/5-HT(2B)] receptor expression and NO release and *inhibiting* 5-HTT/RhoA/ROCK expression and phosphorylation . Negative_regulation HTR4 TNF 1911345 167456 However , the possible *role* of in [HTR] has not been investigated . Negative_regulation HTR6 TNF 1911345 167457 However , the possible *role* of in [HTR] has not been investigated . Negative_regulation HTR7 TNF 1911345 167458 However , the possible *role* of in [HTR] has not been investigated . Negative_regulation HTT TGM2 12528814 1048658 Transient transfection of N-terminally truncated huntingtin with an expanded glutamine domain ( htt-N63-148Q-myc ) with and without and into HEK 293T cells *resulted* in an increase in cross linked [huntingtin] in the insoluble formic acid treated pellet in comparison to transfection of N-terminally truncated huntingtin with normal length glutamine domain ( htt-N63-18Q-myc ) . Negative_regulation HYOU1 FOXO1 21296878 2410340 Forkhead box O1 (FOXO1) was identified as the critical transcription factor regulating ORP150 expression because silencing expression *prevented* the induction of [ORP150] expression by AMPK . Negative_regulation HYOU1 FOXO1 21296878 2410342 In contrast , overexpression of *promoted* [ORP150] expression in hepatocytes . Negative_regulation HYOU1 FOXO1 22564731 2608770 was *involved* in the regulation of [ORP150] expression because suppression of FOXO1 inhibited the induction of ORP150 by SIRT1 . Negative_regulation IBD2 ARSA 21765868 2456663 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Negative_regulation IBD2 ITGAL 14518246 480044 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Negative_regulation IBD2 ITGB2 7648720 318955 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Negative_regulation IBD2 JAG1 15294991 1279081 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Negative_regulation IBD2 PECAM1 17510197 1772774 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Negative_regulation IBD2 TLR7 18031248 1828094 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Negative_regulation IBD2 TNF 16093357 1481978 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Negative_regulation IBD2 TNF 18187519 1876043 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Negative_regulation IBD2 TNF 8734357 374164 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Negative_regulation IBD2 TNFSF10 19954896 2199260 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Negative_regulation IBD3 ARSA 21765868 2456659 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Negative_regulation IBD3 ITGAL 14518246 480040 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Negative_regulation IBD3 ITGB2 7648720 318947 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Negative_regulation IBD3 JAG1 15294991 1279077 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Negative_regulation IBD3 PECAM1 17510197 1772770 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Negative_regulation IBD3 TLR7 18031248 1828054 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Negative_regulation IBD3 TNF 16093357 1481974 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Negative_regulation IBD3 TNF 18187519 1876039 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Negative_regulation IBD3 TNF 8734357 374160 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Negative_regulation IBD3 TNFSF10 19954896 2199256 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Negative_regulation IBD4 ARSA 21765868 2456664 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Negative_regulation IBD4 ITGAL 14518246 480045 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Negative_regulation IBD4 ITGB2 7648720 318957 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Negative_regulation IBD4 JAG1 15294991 1279082 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Negative_regulation IBD4 PECAM1 17510197 1772775 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Negative_regulation IBD4 TLR7 18031248 1828104 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Negative_regulation IBD4 TNF 16093357 1481979 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Negative_regulation IBD4 TNF 18187519 1876044 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Negative_regulation IBD4 TNF 8734357 374165 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Negative_regulation IBD4 TNFSF10 19954896 2199261 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Negative_regulation IBD5 ARSA 21765868 2456665 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Negative_regulation IBD5 ITGAL 14518246 480046 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Negative_regulation IBD5 ITGB2 7648720 318959 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Negative_regulation IBD5 JAG1 15294991 1279083 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Negative_regulation IBD5 PECAM1 17510197 1772776 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Negative_regulation IBD5 TLR7 18031248 1828114 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Negative_regulation IBD5 TNF 16093357 1481980 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Negative_regulation IBD5 TNF 18187519 1876045 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Negative_regulation IBD5 TNF 8734357 374166 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Negative_regulation IBD5 TNFSF10 19954896 2199262 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Negative_regulation IBD6 ARSA 21765868 2456666 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Negative_regulation IBD6 ITGAL 14518246 480047 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Negative_regulation IBD6 ITGB2 7648720 318961 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Negative_regulation IBD6 JAG1 15294991 1279084 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Negative_regulation IBD6 PECAM1 17510197 1772777 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Negative_regulation IBD6 TLR7 18031248 1828124 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Negative_regulation IBD6 TNF 16093357 1481981 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Negative_regulation IBD6 TNF 18187519 1876046 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Negative_regulation IBD6 TNF 8734357 374167 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Negative_regulation IBD6 TNFSF10 19954896 2199263 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Negative_regulation IBD7 ARSA 21765868 2456660 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Negative_regulation IBD7 ITGAL 14518246 480041 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Negative_regulation IBD7 ITGB2 7648720 318949 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Negative_regulation IBD7 JAG1 15294991 1279078 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Negative_regulation IBD7 PECAM1 17510197 1772771 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Negative_regulation IBD7 TLR7 18031248 1828064 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Negative_regulation IBD7 TNF 16093357 1481975 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Negative_regulation IBD7 TNF 18187519 1876040 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Negative_regulation IBD7 TNF 8734357 374161 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Negative_regulation IBD7 TNFSF10 19954896 2199257 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Negative_regulation IBD8 ARSA 21765868 2456661 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Negative_regulation IBD8 ITGAL 14518246 480042 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Negative_regulation IBD8 ITGB2 7648720 318951 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Negative_regulation IBD8 JAG1 15294991 1279079 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Negative_regulation IBD8 PECAM1 17510197 1772772 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Negative_regulation IBD8 TLR7 18031248 1828074 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Negative_regulation IBD8 TNF 16093357 1481976 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Negative_regulation IBD8 TNF 18187519 1876041 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Negative_regulation IBD8 TNF 8734357 374162 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Negative_regulation IBD8 TNFSF10 19954896 2199258 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Negative_regulation IBD9 ARSA 21765868 2456662 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Negative_regulation IBD9 ITGAL 14518246 480043 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Negative_regulation IBD9 ITGB2 7648720 318953 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Negative_regulation IBD9 JAG1 15294991 1279080 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Negative_regulation IBD9 PECAM1 17510197 1772773 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Negative_regulation IBD9 TLR7 18031248 1828084 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Negative_regulation IBD9 TNF 16093357 1481977 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Negative_regulation IBD9 TNF 18187519 1876042 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Negative_regulation IBD9 TNF 8734357 374163 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Negative_regulation IBD9 TNFSF10 19954896 2199259 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Negative_regulation ICAM1 ANGPT1 17085463 1685071 *suppressed* both renal expression of [intercellular adhesion molecule-1] and monocyte chemoattractant protein-1 and monocyte/macrophage infiltration in diabetic db/db mice . Negative_regulation ICAM1 CD14 8945531 400311 Since HGF did not express endogenous CD14 , we investigated the *role* of human serum derived soluble ( sCD14 ) in [ICAM-1] induction on HGF by LPS . Negative_regulation ICAM1 DAPK1 22465880 2588973 In addition , over-expression of from either TNF-a or INF-?-treatment cells *suppressed* the anti-apoptosis protein XIAP as well as COX-2 and [ICAM-1] , more than control . Negative_regulation ICAM1 EPHB2 19823174 2187270 Sulfur dioxide donor significantly downregulated Raf-1 , mitogen activated protein kinase kinase-1 ( MEK-1 ) and , and *inhibited* pulmonary vascular smooth muscle cell proliferation , collagen remodeling and pulmonary vascular endothelial cell nuclear factor-kappaB (NF-kappaB) , and [intercellular adhesion molecule 1] ( ICAM-1 ) expressions . Negative_regulation ICAM1 FUT4 15855822 1404107 or FOY significantly *reduced* protease induced expression of MAC-1 and [ICAM-1] . Negative_regulation ICAM1 IL1B 10397983 627891 The levels of secretion from monocytes were *sufficient* to induce [ICAM-1] expression on HMVECs . Negative_regulation ICAM1 IL1B 10532635 562346 To investigate the *role* of in regulation of tumor necrosis factor-alpha (TNF-alpha) and [intercellular adhesion molecule-1] ( ICAM-1 ) during focal cerebral ischemia , the authors studied mutant mice deficient in the IL-1 converting enzyme (ICE) gene ( ICE knockout [ KO ] mice ) . Negative_regulation ICAM1 IL1B 7513022 253612 The levels of [ICAM-1] expression were *enhanced* in a dose- and time dependent manner by , TNF-alpha , or IFN-gamma , but not by IL-6 or IL-8 . Negative_regulation ICAM1 IL1B 8785389 371452 Stimulation with or TNF alpha *resulted* in time- and dose dependent upregulation of [ICAM-1] mRNA transcript and increased cell-surface immunoreactive protein expression . Negative_regulation ICAM1 IL1B 9197378 438543 In addition , pretreatment of infected monocytes with a TNF-alpha synthesis inhibitor , RP 55778 , or with MAbs directed against IL-1beta , confirmed the *role* of TNF-alpha and in the regulation of CD18 , CD44 , and [CD54] expression . Negative_regulation ICAM1 IL1B 9705828 526086 Inhibition of *induced* COX-2 and elevated [ICAM-1] expression , an effect reversed by exogenous PGE2 . Negative_regulation ICAM1 ITGAL 17053736 1636381 Binding of efalizumab to *prevents* binding of LFA-1 to [ICAM-1] , thus inhibiting several steps in the immunological process responsible for formation of psoriatic plaque ( activation of naive T lymphocytes to memory T lymphocytes , lymphocyte migration and reactivation of T lymphocytes in skin ) . Negative_regulation ICAM1 ITGAL 20190141 2229241 Others have demonstrated that the targeted disruption of : [ICAM] interactions , either by gene deletion or Ab treatment in mice , *results* in reduced leukocyte trafficking , inflammatory responses , and inhibition of inflammatory arthritis in the K/BxN serum transfer model . Negative_regulation ICAM1 ITGB2 10807407 692185 The expression of CD11b and on neutrophils and neutrophil dependent adhesion to endothelial cells elicited by HPE were inhibited by lansoprazole and omeprazole at clinical relevant doses , and the expression of [ICAM-1] and VCAM-1 on endothelial cells and endothelial dependent neutrophil adherence induced by IL-1beta were also *inhibited* by lansoprazole and omeprazole at similar doses . Negative_regulation ICAM1 ITGB2 11165259 782758 Specific phosphatidylinositol-3-kinase (PI3K) inhibitors suppressed both activation and Rap1GTP generation , and abrogation of Rap1GTP by retroviral over-expression of a specific Rap1 GTPase activating protein , SPA-1 , totally *inhibited* the [LFA-1/ICAM-1] mediated cell adhesion . Negative_regulation ICAM1 ITGB2 19258452 2051198 Efalizumab binding to the alphaL I domain *blocks* [ICAM-1] binding via steric hindrance . Negative_regulation ICAM1 ITGB2 21654835 2475802 Targeting and *preventing* interaction with [ICAM-1] has proven an effective strategy for treating psoriasis . Negative_regulation ICAM1 ITGB2 7680657 211630 This [ICAM-1] binding could be achieved by monovalent Fab fragments of mAb MEM-83 at concentrations equivalent to whole antibody , was associated with appearance of the `` activation reporter '' epitope detected by mAb 24 , and was completely *inhibited* by anti-ICAM-1 and blocking mAbs . Negative_regulation ICAM1 MAP2K6 19823174 2187276 Sulfur dioxide donor significantly downregulated Raf-1 , ( MEK-1 ) and p-ERK/ERK , and *inhibited* pulmonary vascular smooth muscle cell proliferation , collagen remodeling and pulmonary vascular endothelial cell nuclear factor-kappaB (NF-kappaB) , and [intercellular adhesion molecule 1] ( ICAM-1 ) expressions . Negative_regulation ICAM1 S100A7 20217214 2362673 Loss of [ICAM-1] signaling *induces* ( S100A7 ) and MUC1 in mammary epithelial cells . Negative_regulation ICAM1 SELL 8449611 214012 CD2 , CD44 , [CD54] and CD58 were *increased* by IL-2 but was strongly down-regulated on the long-term activated NK cells . Negative_regulation ICAM1 SRGN 19123332 2004914 ( 40 mg x kg ( -1 ) d ( -1 ) ) could decrease the serum level of inflammatory factor TNF-alpha , and slightly *inhibit* COX-2 and [ICAM-1] protein expression in ischemic myocardium of AMI rats . Negative_regulation ICAM1 SRGN 19271170 2045710 ( 1-5 mmol/L ) *inhibited* the VEC surface expression of CD62E and [CD54] in a dose dependent way ( ( 1-5 mmol/L ) inhibited the VEC surface expression of CD62E and CD54 in a dose dependent way ( P < 0.05 ) . Negative_regulation ICAM1 TLR7 17054926 1642062 Ligand activation of TLR2 , TLR4 and TLR5 , but not TLR3 , or TLR9 , *resulted* in cardiomyocyte expression of the inflammatory cytokine IL-6 , the chemokines KC and MIP-2 , and the cell surface adhesion molecule [ICAM-1] . Negative_regulation ICAM1 TNF 10407627 629764 *Roles* of and transforming growth factor-beta in regulating [intercellular adhesion molecule-1] expression on murine peritoneal macrophages infected with M. leprae . Negative_regulation ICAM1 TNF 10644010 577713 In *presence* of however , the same SOD mimetic inhibited TNF stimulated [ICAM-1] expression by 25 % in melanoma and 17 % in endothelial cells . Negative_regulation ICAM1 TNF 10718114 676653 Both and NAC , but not L-NAME , *inhibited* elicited ( TNFalpha , SI ) as well as constitutive ( media ) [ICAM-1] expression . Negative_regulation ICAM1 TNF 10760953 683678 In the present report , we show that increased ICAM-1 mRNA levels in human astrocytoma cells and that ethanol markedly *blocked* TNF-alpha induced increases in [ICAM-1] mRNA levels . Negative_regulation ICAM1 TNF 11198351 779646 Stimulation of control cells with *resulted* in reactive oxygen species ( ROS ) generation and activation of NF-kappaB binding to the ICAM-1 promoter and [ICAM-1] transcription . Negative_regulation ICAM1 TNF 11435740 832690 stimulation *resulted* in a 4-fold increase in [ICAM-1] and VCAM-1 expression . Negative_regulation ICAM1 TNF 11461170 839070 Insulin seems to have the ability to suppress the production of and superoxide anion , enhance the synthesis of nitric oxide and *inhibit* the expression of [intercellular adhesion molecule-1] ( ICAM-1 ) through stimulation of nitric oxide . Negative_regulation ICAM1 TNF 11520077 851908 however , IL-18 induced expression of [ICAM-1] in monocytes was not *inhibited* by anti-IL-12 , , or anti-IFN-gamma Ab , suggesting the independence of the upregulating effect of IL-18 on endogenous IL-12 , TNF-alpha , and IFN-gamma production . Negative_regulation ICAM1 TNF 12168501 973636 The effects of cigarette smoke extract on the endothelial production of soluble [intercellular adhesion molecule-1] are *mediated* through macrophages , possibly by inducing release . Negative_regulation ICAM1 TNF 12505729 1038267 PD analyses suggested that in NHS samples containing CsA+SRL ( n=5 ) , ( 1 ) PMA-Ionomycin stimulated T-cell expression of intracellular IL-2 , , and IFN-gamma was inhibited by CsA , and minimally by SRL , and ( 2 ) the two agents *inhibited* pokeweed mitogen ( PWM ) -stimulated B-cell expression of [CD54] and CD95 , but not CD86 ( ICAM-1 , Fas antigen , and B7.2 ) , synergistically . Negative_regulation ICAM1 TNF 12527821 1028288 On TNFalpha activated HUVECs , NAAGA induced a significant decrease in the VCAM-1 expression level ( P < 0.0001 ) and totally reversed *induced* overexpression of [ICAM-1] ( P=0.0069 ) , ICAM-2 and ELAM-1 ( P < 0.0001 ) , without interfering with baseline expression of these molecules . Negative_regulation ICAM1 TNF 12538815 1050396 In the present study , we demonstrate that LPS ( 1-1000 pg/ml ) concentration dependently up-regulated the expression of [intercellular adhesion molecule (ICAM)-1] , B7.1 , and B7.2 on human monocytes using fluorescence activated cell sorting analysis , and that production induced by LPS in peripheral blood mononuclear cells ( PBMCs ) was *inhibited* by the addition of antibodies against these adhesion molecules , suggesting the dependence of TNF-alpha production on cell-cell interaction through these adhesion molecules . Negative_regulation ICAM1 TNF 12714560 1093380 Stimulation of human pulmonary artery endothelial cells with *resulted* in phosphorylation of [ICAM-1] within 1 minute , a response that was sustained up to 15 minutes after TNF-alpha challenge . Negative_regulation ICAM1 TNF 12738545 1087965 Stimulation of keratocytes with *resulted* in an increase in the abundance of ICAM-1 mRNA , the cell surface expression of [ICAM-1] protein , and enhanced adhesion of neutrophils to these cells . Negative_regulation ICAM1 TNF 12919942 1157684 activation of HEMEC *resulted* in upregulation of the cell adhesion molecules (CAM) [ICAM-1] , VCAM-1 , E-selectin , and mucosal addressin CAM-1 (MAdCAM-1) , increased IL-8 production , and enhanced leukocyte binding . Negative_regulation ICAM1 TNF 15698778 1372335 Novel thiocoumarins as inhibitors of *induced* [ICAM-1] expression on human umbilical vein endothelial cells ( HUVECs ) and microsomal lipid peroxidation . Negative_regulation ICAM1 TNF 1695647 137146 Furthermore , IL-4 exhibited significant synergy with IL-1 or TNF in inducing 1.4C3 Ag expression ( p less than 0.001 ) but *inhibited* the increased expression of [ICAM-1] produced by IL-1 , TNF , or IFN-gamma ( p less than 0.01 ) and inhibited the induction of ELAM-1 by IL-1 and ( p less than 0.001 ) . Negative_regulation ICAM1 TNF 17683945 1781397 The interaction between myocardial depressant factors in endotoxemic cardiac dysfunction : *role* of in TLR4 mediated [ICAM-1] expression . Negative_regulation ICAM1 TNF 17683945 1781400 is *involved* in the regulation of myocardial [ICAM-1] expression by TLR4 . Negative_regulation ICAM1 TNF 17909696 1824606 *reduced* [ICAM-1-] and VCAM-1 expression and leukocyte infiltration to levels of non-diabetics and decreased macrophage residence by 3.3-fold compared with untreated diabetics . Negative_regulation ICAM1 TNF 17938380 1825687 Renal and intercellular adhesion molecule-1 expression increased , and Cyp2c23 expression decreased in ANG/HS hypertension compared with the HS group , and CCR2b inhibition *reduced* tumor necrosis factor-alpha and [intercellular adhesion molecule-1] and increased Cyp2c23 expression . Negative_regulation ICAM1 TNF 18387509 1893181 Stimulation of human umbilical vein endothelial cells ( HUVECs ) with *resulted* in the increase of [ICAM-1] and VCAM-1 expressions , while pretreatment with the three components completely inhibited VCAM-1 expression in a dose dependent manner but had no effect on ICAM-1 expression . Negative_regulation ICAM1 TNF 19123332 2004913 PrG ( 40 mg x kg ( -1 ) d ( -1 ) ) could decrease the serum level of inflammatory factor , and slightly *inhibit* COX-2 and [ICAM-1] protein expression in ischemic myocardium of AMI rats . Negative_regulation ICAM1 TNF 19136606 2042719 In the cells cultured under a low-glucose condition when no increased HBP flux occurred , azaserine enhanced the manganese-superoxide dismutase ( MnSOD ) protein level and also inhibited the oxidative stress and the expression of VCAM-1 and [ICAM-1] in *response* to . Negative_regulation ICAM1 TNF 19320886 2052446 at 50 microg/L increased the expression of phospho-ERK and phospho-p38 , and SB203580 , but not PD98059 , could *suppress* the chemotaxis effect and up-regulation of [ICAM-1] induced by TNF-alpha in MSCs ( p < 0.05 ) . Negative_regulation ICAM1 TNF 19627149 2180254 Stimulation of cells with increased ICAM-1 and VCAM-1 expression , and pretreatment with anthocyanins *inhibited* VCAM-1 expression , but not [ICAM-1] expression . Negative_regulation ICAM1 TNF 20156602 2236162 Furthermore , BAI potently inhibits the TNF-alpha induced increase in ROS generation in A549 cells , suggesting that inhibition of ROS generation is maybe involved in the BAI mediated inhibition of *induced* [ICAM-1] down-regulation to A549 cells . Negative_regulation ICAM1 TNF 21349589 2399579 Stimulation of endothelial monolayers with *resulted* in significant increase of toll-like receptor 4 , interleukin-6 and -8 , and [intercellular adhesion molecule-1] and vascular cellular adhesion molecule-1 gene expression in a time dependent manner . Negative_regulation ICAM1 TNF 21419631 2412093 ( S ) - ( + ) -1-chloro-3- ( 2'-chlorophenylamino ) -propan-2-ol has been found to exhibit highest activity , that is , 86 % inhibition of *induced* expression of [ICAM-1] at a concentration of 40 µg/ml . Negative_regulation ICAM1 TNF 23085565 2703493 Stimulation of human umbilical vein endothelial cells ( HUVEC ) with increased ICAM-1 and VCAM-1 expressions , and the pretreatment with tanshinone IIA concentration dependently *inhibited* VCAM-1 expression but not [ICAM-1] expression . Negative_regulation ICAM1 TNF 23264465 2741395 Importantly , ERM knockdown also reduced [ICAM-1] expression in *response* to the proinflammatory cytokine . Negative_regulation ICAM1 TNF 7513022 253610 The levels of [ICAM-1] expression were *enhanced* in a dose- and time dependent manner by IL-1 beta , , or IFN-gamma , but not by IL-6 or IL-8 . Negative_regulation ICAM1 TNF 7578984 333393 The current study was undertaken to investigate the *role* of in regulation of E-selectin and [ICAM-1] expression by TNF on HUVEC . Negative_regulation ICAM1 TNF 7692987 231208 partially *inhibited* the increase in VCAM-1 and [ICAM-1] expression , indicating that TNF in part mediates VCAM-1 and ICAM-1 expression . Negative_regulation ICAM1 TNF 7693840 234236 Of the neutralizing antibodies used against these cytokines , only could significantly *inhibit* VCAM-1 and [ICAM-1] expression . Negative_regulation ICAM1 TNF 8785389 371451 Stimulation with IL-1 beta or *resulted* in time- and dose dependent upregulation of [ICAM-1] mRNA transcript and increased cell-surface immunoreactive protein expression . Negative_regulation ICAM1 TNF 8822088 384795 However , in the in vitro study , FK506 failed to inhibit the up-regulated [ICAM-1] expression on endothelial cells in *response* to . Negative_regulation ICAM1 TNF 8904994 394043 Stimulation with ( TNF-alpha ) and interferon-gamma (IFN-gamma) *resulted* , in addition to interleukin-(IL-)4 , in selective upregulation of [ICAM-1] expression . Negative_regulation ICAM1 TNF 9155652 431619 The specific *role* of in mediating [ICAM-1] expression in cultured monocytes could be confirmed by the finding that a neutralizing anti-TNF-alpha antibody partially down-regulated ICAM-1 expression . Negative_regulation ICAM1 TNF 9197378 438542 In addition , pretreatment of infected monocytes with a TNF-alpha synthesis inhibitor , RP 55778 , or with MAbs directed against IL-1beta , confirmed the *role* of and IL-1beta in the regulation of CD18 , CD44 , and [CD54] expression . Negative_regulation ICAM1 TNF 9414135 471835 As TNF is a potent inducer of ICAM-1 expression , it is concluded that in these experiments the inhibition of production by PTX concomitantly *resulted* in the inhibition of the upregulation of [ICAM-1] . Negative_regulation ICAM1 TNF 9674607 520223 Our study demonstrated that blocking reduced brain injury and *attenuated* [ICAM-1] expression during transient cerebral ischemia . Negative_regulation ICAM2 ITGAL 20190141 2229242 Others have demonstrated that the targeted disruption of : [ICAM] interactions , either by gene deletion or Ab treatment in mice , *results* in reduced leukocyte trafficking , inflammatory responses , and inhibition of inflammatory arthritis in the K/BxN serum transfer model . Negative_regulation ICAM2 TNF 11719371 883682 It has recently been shown that the transcription factor Erg , an Ets family member , drives constitutive expression of the [intercellular adhesion molecule 2] ( ICAM-2 ) in human umbilical vein endothelial cells ( HUVECs ) and that its expression is *down-regulated* by the pleiotropic cytokine . Negative_regulation ICAM2 TNF 12527821 1028289 On TNFalpha activated HUVECs , NAAGA induced a significant decrease in the VCAM-1 expression level ( P < 0.0001 ) and totally reversed *induced* overexpression of ICAM-1 ( P=0.0069 ) , [ICAM-2] and ELAM-1 ( P < 0.0001 ) , without interfering with baseline expression of these molecules . Negative_regulation ICAM3 ITGAL 20190141 2229243 Others have demonstrated that the targeted disruption of : [ICAM] interactions , either by gene deletion or Ab treatment in mice , *results* in reduced leukocyte trafficking , inflammatory responses , and inhibition of inflammatory arthritis in the K/BxN serum transfer model . Negative_regulation ICAM4 ITGAL 20190141 2229244 Others have demonstrated that the targeted disruption of : [ICAM] interactions , either by gene deletion or Ab treatment in mice , *results* in reduced leukocyte trafficking , inflammatory responses , and inhibition of inflammatory arthritis in the K/BxN serum transfer model . Negative_regulation ICAM5 ITGAL 20190141 2229245 Others have demonstrated that the targeted disruption of : [ICAM] interactions , either by gene deletion or Ab treatment in mice , *results* in reduced leukocyte trafficking , inflammatory responses , and inhibition of inflammatory arthritis in the K/BxN serum transfer model . Negative_regulation ICOS EPHB2 16880206 1613763 Here , we report that Fyn , NFAT , and signaling influence ICOS expression as various chemical inhibitors , such as PP2 that targets Src kinases , U0126 that targets MEK1/2 , and cyclosporin A or FK506 that targets calcineurin and thereby affects NFAT , *attenuate* T cell receptor mediated [ICOS] induction . Negative_regulation ID1 ABL1 17132628 1686696 Inhibition of by the chemical inhibitor STI571 *resulted* in activation of FOXO3a and down-regulation of [Id1] expression . Negative_regulation ID1 ACVRL1 20060813 2205451 Overexpression of both ENG and significantly *increased* BRE but not CAGA activity , expression of [ID1] and BCL-X and the number of HAECs at hypoxia . Negative_regulation ID1 ACVRL1 20124460 2207064 In cell based assays , *inhibited* BMP9 mediated [Id-1] expression in human umbilical vein endothelial cells and inhibited cord formation by these cells on a Matrigel substrate . Negative_regulation ID1 AKT1 17132628 1686687 Inhibition of activation or growth factor deprivation also *resulted* in strong down-regulation of [Id1] promoter activity , Id1 mRNA , and protein expression . Negative_regulation ID1 ATF1 18922905 1977356 Mutagenesis experiments with the 2.1-kb human Id-1 promoter revealed that 3 ( ATF3 ) and Smad interaction , with their respective binding motifs , was *essential* for REIC/Dkk-3 mediated suppression of [Id-1] promoter activity . Negative_regulation ID1 ATF2 18922905 1977357 Mutagenesis experiments with the 2.1-kb human Id-1 promoter revealed that 3 ( ATF3 ) and Smad interaction , with their respective binding motifs , was *essential* for REIC/Dkk-3 mediated suppression of [Id-1] promoter activity . Negative_regulation ID1 ATF3 17102133 1676587 Here we show that Id-1 is down-regulated in multiple primary , immortalized , and neoplastic hypoxic cell lines , and the transcriptional repressor is both *necessary* and sufficient for this hypoxia induced repression of [Id-1] . Negative_regulation ID1 ATF3 17102133 1676588 Hypoxic neuroblastoma cells diminish expression of some neuronal differentiation markers , and forced expression of in hypoxic neuroblastoma cells *represses* [Id-1] and prevents the loss of these markers . Negative_regulation ID1 ATF3 18922905 1977358 Mutagenesis experiments with the 2.1-kb human Id-1 promoter revealed that 3 ( ATF3 ) and Smad interaction , with their respective binding motifs , was *essential* for REIC/Dkk-3 mediated suppression of [Id-1] promoter activity . Negative_regulation ID1 ATF3 18922905 1977371 In summary , we first showed that both and Smad were crucially and synergistically *involved* in down-regulation of [Id-1] , which regulated JNK phosphorylation in REIC/Dkk-3 induced apoptosis . Negative_regulation ID1 ATF4 18922905 1977359 Mutagenesis experiments with the 2.1-kb human Id-1 promoter revealed that 3 ( ATF3 ) and Smad interaction , with their respective binding motifs , was *essential* for REIC/Dkk-3 mediated suppression of [Id-1] promoter activity . Negative_regulation ID1 ATF5 18922905 1977360 Mutagenesis experiments with the 2.1-kb human Id-1 promoter revealed that 3 ( ATF3 ) and Smad interaction , with their respective binding motifs , was *essential* for REIC/Dkk-3 mediated suppression of [Id-1] promoter activity . Negative_regulation ID1 ATF6 18922905 1977361 Mutagenesis experiments with the 2.1-kb human Id-1 promoter revealed that 3 ( ATF3 ) and Smad interaction , with their respective binding motifs , was *essential* for REIC/Dkk-3 mediated suppression of [Id-1] promoter activity . Negative_regulation ID1 ATF7 18922905 1977362 Mutagenesis experiments with the 2.1-kb human Id-1 promoter revealed that 3 ( ATF3 ) and Smad interaction , with their respective binding motifs , was *essential* for REIC/Dkk-3 mediated suppression of [Id-1] promoter activity . Negative_regulation ID1 BAG6 22130070 2515132 overexpression in murine cell lines *suppresses* the activity of the [Id1] promoter normally induced by BMP signaling . Negative_regulation ID1 BCR 17132628 1686693 Inhibition of by the chemical inhibitor STI571 *resulted* in activation of FOXO3a and down-regulation of [Id1] expression . Negative_regulation ID1 BMP6 16413393 1513971 *inhibits* human bone marrow B lymphopoiesis -- upregulation of [Id1] and Id3 . Negative_regulation ID1 BMP6 20032053 2210982 Nevertheless , in vitro , stimulation of ovine granulosa cells with or activin A *led* to a respective increase and decrease in [Id1] ( P < 0.0001 ) , Id2 ( P < 0.0001 ) , Id3 ( P < 0.0001 ) , and Id4 ( P < 0.05 ) transcripts , and Id1 gene expression was further manipulated by the oocyte secreted factors BMP15 and growth differentiation factor 9 ( P < 0.001 ) . Negative_regulation ID1 CCNA2 18764931 1969032 Furthermore , using TaqMan Low-density Arrays we identified key pro-angiogenic genes induced by CRP among them were vascular endothelial cell growth factor receptor-2 ( VEGFR2/KDR ) , platelet derived growth factor ( PDGF-BB ) , notch family transcription factors ( Notch1 and Notch3 ) , cysteine-rich angiogenic inducer 61 ( ) and *inhibitor* of DNA binding/differentiation-1 ( [ID1] ) . Negative_regulation ID1 CD79A 17132628 1686694 Inhibition of by the chemical inhibitor STI571 *resulted* in activation of FOXO3a and down-regulation of [Id1] expression . Negative_regulation ID1 CD79B 17132628 1686695 Inhibition of by the chemical inhibitor STI571 *resulted* in activation of FOXO3a and down-regulation of [Id1] expression . Negative_regulation ID1 CDH1 18372912 1938164 On the other hand , overexpression of *leads* to [Id-1] protein degradation , suggesting that Id-1 may also act as a substrate of APC ( Cdh1 ) . Negative_regulation ID1 CYR61 18764931 1969033 Furthermore , using TaqMan Low-density Arrays we identified key pro-angiogenic genes induced by CRP among them were vascular endothelial cell growth factor receptor-2 ( VEGFR2/KDR ) , platelet derived growth factor ( PDGF-BB ) , notch family transcription factors ( Notch1 and Notch3 ) , cysteine-rich angiogenic inducer 61 ( ) and *inhibitor* of DNA binding/differentiation-1 ( [ID1] ) . Negative_regulation ID1 DKK3 18922905 1977347 Mutagenesis experiments with the 2.1-kb human Id-1 promoter revealed that activating transcription factor 3 ( ATF3 ) and Smad interaction , with their respective binding motifs , was essential for *mediated* suppression of [Id-1] promoter activity . Negative_regulation ID1 EGR1 18842581 1994082 The ability of PGE ( 2 ) to activate [Id-1] transcription was *mediated* by enhanced binding of to the Id-1 promoter . Negative_regulation ID1 EGR1 8628310 356233 On the basis of these findings , we propose that the regulation of the [Id1] response to serum is *mediated* in part by the early response gene and as such provides a signaling link between the early-growth-response transcription factors and dominant negative helix-loop-helix proteins . Negative_regulation ID1 ENG 20060813 2205452 Overexpression of both and ALK-1 significantly *increased* BRE but not CAGA activity , expression of [ID1] and BCL-X and the number of HAECs at hypoxia . Negative_regulation ID1 FGF2 21506108 2418464 Although regulation of Id-1 protein by several mitogenic factors is well established , little is known about the *role* of in the regulation of [Id-1] . Negative_regulation ID1 GJA1 24457967 2907505 Our results show that both the ectopic expression of and the inhibition of c-Src *reduced* [Id1] , Sox2 expression and promoted the switch from N- to E-cadherin , suggesting that Cx43 , by inhibiting c-Src , downregulates Id1 with the subsequent changes in stem cell phenotype . Negative_regulation ID1 HGF 19567783 2111196 [Id1] is *down-regulated* by via ERK dependent and ERK independent signaling pathways , leading to increased expression of p16INK4a in hepatoma cells . Negative_regulation ID1 ID2 21732357 2538867 Importantly , IL-3 *induced* inhibitor of DNA binding/differentiation ( [Id)1] in hBMMs , while were sustained during osteoclast differentiation of mBMMs treated with IL-3 . Negative_regulation ID1 IGF1 21062988 2344903 Similarly , *suppressed* BMP4 induced transcription of the [Id1] , Id2 , and Id3 genes that are crucially involved in prostate tumor progression through PI3K dependent and mTORC1/2 dependent mechanisms . Negative_regulation ID1 INHBA 20032053 2210983 Nevertheless , in vitro , stimulation of ovine granulosa cells with BMP6 or *led* to a respective increase and decrease in [Id1] ( P < 0.0001 ) , Id2 ( P < 0.0001 ) , Id3 ( P < 0.0001 ) , and Id4 ( P < 0.05 ) transcripts , and Id1 gene expression was further manipulated by the oocyte secreted factors BMP15 and growth differentiation factor 9 ( P < 0.001 ) . Negative_regulation ID1 MAPK3 18436795 1915411 Furthermore , activation of by platelet derived growth factor BB also caused Smad1 linker region phosphorylation and *inhibited* BMP4 induced [Id1] gene expression . Negative_regulation ID1 MEFV 20956996 2382152 OSM downregulated myocyte enhancer binding factor 2A ( MEF2A ) , upregulated the expression of [Id1] and Id2 , and *inhibited* the transcriptional activity of MyoD and . Negative_regulation ID1 MIR381 22592211 2614432 *represses* [ID1] and is deregulated in lung adenocarcinoma . Negative_regulation ID1 MYC 15489884 1359458 Inhibition of function by siRNA , antisense oligonucleotides or a dominant repressor *resulted* in downregulation of [Id1] , while ectopic expression of c-Myc resulted in rapid induction of Id1 , suggesting that Id1 may be downstream of c-Myc . Negative_regulation ID1 MYLIP 22249264 2668237 Expression of *suppressed* [ID1] levels and significantly reduced migration and invasion . Negative_regulation ID1 OPN1MW 20859676 2452749 We show that inhibits human breast cancer cell proliferation and invasion through differential modulation of the extracellular signal regulated kinase ( ERK ) and reactive oxygen species ( ROS ) pathways , and that both pathways *lead* to down-regulation of [Id-1] expression . Negative_regulation ID1 RGMB 19422419 2135766 In C2C12 cells , only *suppressed* ALP and [Id1] promoter activities induced by BMP-4 or by constitutively activated BMP type I receptors . Negative_regulation ID1 SMAD1 18436795 1915410 Furthermore , activation of ERK1/2 by platelet derived growth factor BB also caused linker region phosphorylation and *inhibited* BMP4 induced [Id1] gene expression . Negative_regulation ID1 SMAD1 18922905 1977348 Mutagenesis experiments with the 2.1-kb human Id-1 promoter revealed that activating transcription factor 3 ( ATF3 ) and interaction , with their respective binding motifs , was *essential* for REIC/Dkk-3 mediated suppression of [Id-1] promoter activity . Negative_regulation ID1 SMAD1 18922905 1977363 In summary , we first showed that both ATF3 and were crucially and synergistically *involved* in down-regulation of [Id-1] , which regulated JNK phosphorylation in REIC/Dkk-3 induced apoptosis . Negative_regulation ID1 SMAD2 18922905 1977349 Mutagenesis experiments with the 2.1-kb human Id-1 promoter revealed that activating transcription factor 3 ( ATF3 ) and interaction , with their respective binding motifs , was *essential* for REIC/Dkk-3 mediated suppression of [Id-1] promoter activity . Negative_regulation ID1 SMAD2 18922905 1977364 In summary , we first showed that both ATF3 and were crucially and synergistically *involved* in down-regulation of [Id-1] , which regulated JNK phosphorylation in REIC/Dkk-3 induced apoptosis . Negative_regulation ID1 SMAD3 18922905 1977350 Mutagenesis experiments with the 2.1-kb human Id-1 promoter revealed that activating transcription factor 3 ( ATF3 ) and interaction , with their respective binding motifs , was *essential* for REIC/Dkk-3 mediated suppression of [Id-1] promoter activity . Negative_regulation ID1 SMAD3 18922905 1977365 In summary , we first showed that both ATF3 and were crucially and synergistically *involved* in down-regulation of [Id-1] , which regulated JNK phosphorylation in REIC/Dkk-3 induced apoptosis . Negative_regulation ID1 SMAD4 18922905 1977351 Mutagenesis experiments with the 2.1-kb human Id-1 promoter revealed that activating transcription factor 3 ( ATF3 ) and interaction , with their respective binding motifs , was *essential* for REIC/Dkk-3 mediated suppression of [Id-1] promoter activity . Negative_regulation ID1 SMAD4 18922905 1977366 In summary , we first showed that both ATF3 and were crucially and synergistically *involved* in down-regulation of [Id-1] , which regulated JNK phosphorylation in REIC/Dkk-3 induced apoptosis . Negative_regulation ID1 SMAD5 18922905 1977352 Mutagenesis experiments with the 2.1-kb human Id-1 promoter revealed that activating transcription factor 3 ( ATF3 ) and interaction , with their respective binding motifs , was *essential* for REIC/Dkk-3 mediated suppression of [Id-1] promoter activity . Negative_regulation ID1 SMAD5 18922905 1977367 In summary , we first showed that both ATF3 and were crucially and synergistically *involved* in down-regulation of [Id-1] , which regulated JNK phosphorylation in REIC/Dkk-3 induced apoptosis . Negative_regulation ID1 SMAD6 14645520 1172183 Here , we present compelling evidence demonstrating that *repressed* bone morphogenetic protein induced [Id1] transcription through recruiting transcriptional corepressor C-terminal binding protein (CtBP) . Negative_regulation ID1 SMAD6 18922905 1977353 Mutagenesis experiments with the 2.1-kb human Id-1 promoter revealed that activating transcription factor 3 ( ATF3 ) and interaction , with their respective binding motifs , was *essential* for REIC/Dkk-3 mediated suppression of [Id-1] promoter activity . Negative_regulation ID1 SMAD6 18922905 1977368 In summary , we first showed that both ATF3 and were crucially and synergistically *involved* in down-regulation of [Id-1] , which regulated JNK phosphorylation in REIC/Dkk-3 induced apoptosis . Negative_regulation ID1 SMAD7 18922905 1977354 Mutagenesis experiments with the 2.1-kb human Id-1 promoter revealed that activating transcription factor 3 ( ATF3 ) and interaction , with their respective binding motifs , was *essential* for REIC/Dkk-3 mediated suppression of [Id-1] promoter activity . Negative_regulation ID1 SMAD7 18922905 1977369 In summary , we first showed that both ATF3 and were crucially and synergistically *involved* in down-regulation of [Id-1] , which regulated JNK phosphorylation in REIC/Dkk-3 induced apoptosis . Negative_regulation ID1 SMAD9 18922905 1977355 Mutagenesis experiments with the 2.1-kb human Id-1 promoter revealed that activating transcription factor 3 ( ATF3 ) and interaction , with their respective binding motifs , was *essential* for REIC/Dkk-3 mediated suppression of [Id-1] promoter activity . Negative_regulation ID1 SMAD9 18922905 1977370 In summary , we first showed that both ATF3 and were crucially and synergistically *involved* in down-regulation of [Id-1] , which regulated JNK phosphorylation in REIC/Dkk-3 induced apoptosis . Negative_regulation ID1 TGFB1 16391861 1505905 Induction by dose-dependently *suppressed* [Id1] expression in HuH7 cells ; Negative_regulation ID1 TGFB1 19798702 2186978 *suppressed* [Id-1] Expression in a smad3 dependent manner in LoVo cells . Negative_regulation ID1 TGFB1 19798702 2186999 Moreover , *stimulated* cellular proliferation and p21 ( Waf1 ) protein expression , which might be mediated by suppressing [Id-1] expression . Negative_regulation ID1 TGFB1 19798702 2187001 In conclusion , this study demonstrated that *suppressed* [Id-1] expression in a smad3 dependent manner in LoVo cells using RNAi technology . Negative_regulation ID1 TGFB2 19798702 2186979 *suppressed* [Id-1] Expression in a smad3 dependent manner in LoVo cells . Negative_regulation ID1 TGFB3 19798702 2186980 *suppressed* [Id-1] Expression in a smad3 dependent manner in LoVo cells . Negative_regulation ID1 TNFSF11 16322470 1533069 Expression levels of [Id1] , Id2 , and Id3 genes are significantly *reduced* by during osteoclastogenesis . Negative_regulation ID1 TP53 18556654 1946101 [ID1] , inhibitor of differentiation/DNA binding , is an effector of the *dependent* DNA damage response pathway . Negative_regulation ID1 TRIM28 21876767 2473935 MAGE I expression relieved *mediated* [ID1] repression , causing increased expression of ID1 mRNA and ID1 chromatin relaxation characterized by loss of H3me3K9 . Negative_regulation ID1 USP1 24130053 2878957 A known inhibitor , pimozide , also *promoted* [ID1] degradation and inhibited growth of leukemic cells . Negative_regulation ID1 USP1 24130053 2878958 Collectively , these results indicate that the novel small-molecule inhibitors of *promote* [ID1] degradation and are cytotoxic to leukemic cells . Negative_regulation ID2 IL1B 17631285 1787498 Overexpression of early growth response-1 (Egr-1) in VSMC *induced* [Id2] expression while induced Id2 expression was abrogated in VSMC by the Egr-1 repressor , NGFI-A binding protein 2 (NAB2) , expressed from an adenovirus . Negative_regulation IDDM10 FAS 11321233 806973 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Negative_regulation IDDM10 TNF 10436260 634509 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Negative_regulation IDDM10 TNF 9685802 521702 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Negative_regulation IDDM11 FAS 11321233 806975 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Negative_regulation IDDM11 TNF 10436260 634510 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Negative_regulation IDDM11 TNF 9685802 521703 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Negative_regulation IDDM12 FAS 11321233 806977 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Negative_regulation IDDM12 TNF 10436260 634511 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Negative_regulation IDDM12 TNF 9685802 521704 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Negative_regulation IDDM13 FAS 11321233 806979 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Negative_regulation IDDM13 TNF 10436260 634512 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Negative_regulation IDDM13 TNF 9685802 521705 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Negative_regulation IDDM14 FAS 11321233 806981 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Negative_regulation IDDM14 TNF 10436260 634513 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Negative_regulation IDDM14 TNF 9685802 521706 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Negative_regulation IDDM15 FAS 11321233 806983 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Negative_regulation IDDM15 TNF 10436260 634514 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Negative_regulation IDDM15 TNF 9685802 521707 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Negative_regulation IDDM16 FAS 11321233 806985 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Negative_regulation IDDM16 TNF 10436260 634515 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Negative_regulation IDDM16 TNF 9685802 521708 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Negative_regulation IDDM17 FAS 11321233 806987 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Negative_regulation IDDM17 TNF 10436260 634516 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Negative_regulation IDDM17 TNF 9685802 521709 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Negative_regulation IDDM18 FAS 11321233 806989 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Negative_regulation IDDM18 TNF 10436260 634517 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Negative_regulation IDDM18 TNF 9685802 521710 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Negative_regulation IDDM2 FAS 11321233 806991 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Negative_regulation IDDM2 TNF 10436260 634518 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Negative_regulation IDDM2 TNF 9685802 521711 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Negative_regulation IDDM3 FAS 11321233 806993 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Negative_regulation IDDM3 TNF 10436260 634519 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Negative_regulation IDDM3 TNF 9685802 521712 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Negative_regulation IDDM4 FAS 11321233 806995 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Negative_regulation IDDM4 TNF 10436260 634520 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Negative_regulation IDDM4 TNF 9685802 521713 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Negative_regulation IDDM5 FAS 11321233 806997 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Negative_regulation IDDM5 TNF 10436260 634521 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Negative_regulation IDDM5 TNF 9685802 521714 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Negative_regulation IDDM6 FAS 11321233 806999 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Negative_regulation IDDM6 TNF 10436260 634522 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Negative_regulation IDDM6 TNF 9685802 521715 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Negative_regulation IDDM7 FAS 11321233 807001 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Negative_regulation IDDM7 TNF 10436260 634523 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Negative_regulation IDDM7 TNF 9685802 521716 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Negative_regulation IDDM8 FAS 11321233 807003 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Negative_regulation IDDM8 TNF 10436260 634524 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Negative_regulation IDDM8 TNF 9685802 521717 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Negative_regulation IDDM9 FAS 11321233 807005 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Negative_regulation IDDM9 TNF 10436260 634525 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Negative_regulation IDDM9 TNF 9685802 521718 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Negative_regulation IDE TNF 18768842 1957113 IFN-gamma and directly *reduced* the expression of [insulin degrading enzyme] and chaperone molecules ( heat shock protein 70 and heat shock cognate protein 70 ) , which are involved in refolding of aggregated proteins . Negative_regulation IDO1 TNF 10721095 579366 For example we have found that TNF-alpha *enhances* IFN-gamma induced [IDO] activity and antimicrobial effect in human glioblastoma cells whereas both IFN-gamma mediated effects were blocked by as well as by IL-1 in a human uroepithelial cell line . Negative_regulation IDO1 TNF 10721095 579375 We were able to show that the IL-1 and mediated *inhibition* of IFN-gamma induced [IDO] activity in uroepithelial cells is due to stimulation of inducible nitric oxide synthase . Negative_regulation IDO1 TNF 10721095 579381 In human astrocytoma cells , IL-1 and did not *inhibit* [IDO] activity and in concordance with this finding these cells did not show a detectable nitric oxide production . Negative_regulation IDO1 TNF 24696473 2949410 EBV infection also activated the mitogen activated protein kinase (MAPK) p38 and NF-?B , and the inhibition of these two pathways with SB202190 and SN50 almost abrogated and IL-6 production and *inhibited* [IDO] production . Negative_regulation IFI27 ABL1 11010972 752614 We demonstrate that the decrease of [p27] ( Kip1 ) is directly *due* to in hematopoietic cells by two different approaches . Negative_regulation IFI27 AHSA1 21847367 2468644 Increasing TßRIII expression in colon cancer model systems enhanced ligand mediated phosphorylation of and the Smad proteins , while switching TGF-ß and BMP-2 from inhibitors to stimulators of colon cancer cell proliferation , *inhibiting* ligand induced p21 and [p27] expression . Negative_regulation IFI27 AIM2 21057088 2354589 We found that the deficiency in immune cells *stimulated* the expression of [Ifi202] gene . Negative_regulation IFI27 AIM2 21551362 2440710 The deficiency in mice activates IFN signaling and *stimulates* the expression of the lupus susceptibility gene , the [Ifi202] , located within the NZB autoimmunity 2 ( Nba2 ) interval . Negative_regulation IFI27 AKT1 11470779 860354 These data provide the first evidence that Akt kinase regulates PDGF induced DNA synthesis by regulating CDK2 activity and define *mediated* inhibition of transcription of [p27] ( kip1 ) as one of the mechanisms for PDGF induced DNA synthesis in mesangial cells . Negative_regulation IFI27 AKT1 12244302 992792 Thus , we show a novel mechanism whereby *impairs* [p27] function that is associated with an aggressive phenotype in human breast cancer . Negative_regulation IFI27 AKT1 19158484 2027284 Inhibition of [p27] ( Kip1 ) gene expression by PDGF *required* protein synthesis and histone deacetylase activity but not or ERK activity . Negative_regulation IFI27 AKT1 19266163 2055593 Galectin-1 induced increase in cyclin expression and decrease in [p27] ( kip1 ) was *blocked* by inhibitor and rapamycin . Negative_regulation IFI27 AKT1 20823108 2336474 Western blot analysis revealed that honokiol : ( i ) inhibited the levels of cyclins D1 , D2 and E and associated cyclin dependent kinases (CDKs)2 , CDK4 and CDK6 , ( ii ) upregulated Cip/p21 and [Kip/p27] and ( iii ) *inhibited* the levels of phosphatidylinositol 3-kinase and the phosphorylation of at Ser ( 473 ) in UVB induced skin tumors . Negative_regulation IFI27 AKT1 23424995 2809662 Overexpression of , but not of AKT2 , induced p21/p27 phosphorylation and *increased* cytosolic [p21/p27] levels , as did homocysteine treatment . Negative_regulation IFI27 AKT2 11470779 860355 These data provide the first evidence that Akt kinase regulates PDGF induced DNA synthesis by regulating CDK2 activity and define mediated *inhibition* of transcription of [p27] ( kip1 ) as one of the mechanisms for PDGF induced DNA synthesis in mesangial cells . Negative_regulation IFI27 AKT2 12244302 992793 Thus , we show a novel mechanism whereby *impairs* [p27] function that is associated with an aggressive phenotype in human breast cancer . Negative_regulation IFI27 AKT2 19158484 2027285 Inhibition of [p27] ( Kip1 ) gene expression by PDGF *required* protein synthesis and histone deacetylase activity but not or ERK activity . Negative_regulation IFI27 AKT2 19266163 2055594 Galectin-1 induced increase in cyclin expression and decrease in [p27] ( kip1 ) was *blocked* by inhibitor and rapamycin . Negative_regulation IFI27 AKT2 20823108 2336475 Western blot analysis revealed that honokiol : ( i ) inhibited the levels of cyclins D1 , D2 and E and associated cyclin dependent kinases (CDKs)2 , CDK4 and CDK6 , ( ii ) upregulated Cip/p21 and [Kip/p27] and ( iii ) *inhibited* the levels of phosphatidylinositol 3-kinase and the phosphorylation of at Ser ( 473 ) in UVB induced skin tumors . Negative_regulation IFI27 AKT3 11470779 860356 These data provide the first evidence that Akt kinase regulates PDGF induced DNA synthesis by regulating CDK2 activity and define *mediated* inhibition of transcription of [p27] ( kip1 ) as one of the mechanisms for PDGF induced DNA synthesis in mesangial cells . Negative_regulation IFI27 AKT3 12244302 992794 Thus , we show a novel mechanism whereby *impairs* [p27] function that is associated with an aggressive phenotype in human breast cancer . Negative_regulation IFI27 AKT3 19158484 2027286 Inhibition of [p27] ( Kip1 ) gene expression by PDGF *required* protein synthesis and histone deacetylase activity but not or ERK activity . Negative_regulation IFI27 AKT3 19266163 2055595 Galectin-1 induced increase in cyclin expression and decrease in [p27] ( kip1 ) was *blocked* by inhibitor and rapamycin . Negative_regulation IFI27 AKT3 20823108 2336476 Western blot analysis revealed that honokiol : ( i ) inhibited the levels of cyclins D1 , D2 and E and associated cyclin dependent kinases (CDKs)2 , CDK4 and CDK6 , ( ii ) upregulated Cip/p21 and [Kip/p27] and ( iii ) *inhibited* the levels of phosphatidylinositol 3-kinase and the phosphorylation of at Ser ( 473 ) in UVB induced skin tumors . Negative_regulation IFI27 ANXA6 15166254 1288304 These data suggest that TSH regulates cell cycle progression , in part , by increasing the number of cycling cells through *mediated* effects on the localization of [p27] . Negative_regulation IFI27 ATOH1 17113786 1677105 Overexpression of the prosensory transcription factor , , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , [p27Kip] , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation IFI27 BCL10 19112177 2036823 Taken together , our findings indicate that HINT1 up-regulates cellular levels of p27 ( KIP1 ) by two mechanisms : 1 ) it inhibits its ubiquitylation by targeting the SCF ( SKP2 ) , and 2 ) it *inhibits* the phosphorylation of [p27] ( KIP1 ) by Src via inhibiting Src expression . Negative_regulation IFI27 BCR 11010972 752611 We demonstrate that the decrease of [p27] ( Kip1 ) is directly *due* to in hematopoietic cells by two different approaches . Negative_regulation IFI27 BCR 11704865 879397 We show that stimulation of WEHI 231 cells *results* in down-regulation of cyclin D2 and up-regulation of [p27] ( Kip1 ) , which are associated with pocket protein hypophosphorylation and E2F inactivation . Negative_regulation IFI27 BRCA1 15208652 1281270 We hypothesize that disruption of *induces* an increase in [p27] that inhibits proliferation . Negative_regulation IFI27 BTRC 19112177 2036817 Taken together , our findings indicate that HINT1 up-regulates cellular levels of p27 ( KIP1 ) by two mechanisms : 1 ) it inhibits its ubiquitylation by targeting the ( SKP2 ) ubiquitin ligase complex , and 2 ) it *inhibits* the phosphorylation of [p27] ( KIP1 ) by Src via inhibiting Src expression . Negative_regulation IFI27 BTRC 19258007 2051170 *down-regulated* the expression of [p27KIP1] and pro-apoptotic factors such as Bim , Bad , and Bax , and this activity was reversed by LY 294002 . Negative_regulation IFI27 CASP1 15059916 1230413 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Negative_regulation IFI27 CASP10 15059916 1230414 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Negative_regulation IFI27 CASP12 15059916 1230424 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Negative_regulation IFI27 CASP14 15059916 1230415 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Negative_regulation IFI27 CASP16 15059916 1230425 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Negative_regulation IFI27 CASP2 15059916 1230416 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Negative_regulation IFI27 CASP3 15059916 1230417 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Negative_regulation IFI27 CASP4 15059916 1230418 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Negative_regulation IFI27 CASP5 15059916 1230419 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Negative_regulation IFI27 CASP6 15059916 1230420 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Negative_regulation IFI27 CASP7 15059916 1230421 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Negative_regulation IFI27 CASP8 15059916 1230422 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Negative_regulation IFI27 CASP9 15059916 1230423 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Negative_regulation IFI27 CCND1 17438373 1729264 Conversely , loss of by siRNA *causes* [p27] accumulation . Negative_regulation IFI27 CCND1 18697201 1955465 While LTF treatment downregulated expression of and phosphorylation of retinoblastoma protein ( Rb ) , expression of p21 and [p27] in 5-8F NPC cells was *enhanced* . Negative_regulation IFI27 CCND1 20642839 2297558 SFN induced the expression of p21/CIP1 and [p27/KIP1] , and *inhibited* the expression of . Negative_regulation IFI27 CCND1 23497867 2756588 The results show that regarding cell cycle related proteins , three types of polysaccharides significantly *enhance* the expression of [p27] ( Kip ) in HepG2 and Bel-7404 cells , while suppressing the activity of and/or cyclin E/CDK2 . Negative_regulation IFI27 CCNE1 23497867 2756589 The results show that regarding cell cycle related proteins , three types of polysaccharides significantly *enhance* the expression of [p27] ( Kip ) in HepG2 and Bel-7404 cells , while suppressing the activity of cyclin D1/CDK4 and/or . Negative_regulation IFI27 CD79A 11010972 752612 We demonstrate that the decrease of [p27] ( Kip1 ) is directly *due* to in hematopoietic cells by two different approaches . Negative_regulation IFI27 CD79A 11704865 879398 We show that stimulation of WEHI 231 cells *results* in down-regulation of cyclin D2 and up-regulation of [p27] ( Kip1 ) , which are associated with pocket protein hypophosphorylation and E2F inactivation . Negative_regulation IFI27 CD79B 11010972 752613 We demonstrate that the decrease of [p27] ( Kip1 ) is directly *due* to in hematopoietic cells by two different approaches . Negative_regulation IFI27 CD79B 11704865 879399 We show that stimulation of WEHI 231 cells *results* in down-regulation of cyclin D2 and up-regulation of [p27] ( Kip1 ) , which are associated with pocket protein hypophosphorylation and E2F inactivation . Negative_regulation IFI27 CDK2 10383891 624678 Under these conditions , and CDK4 protein expression remained unchanged compared with proliferating cells , but expression of cyclin D1 and [p27] ( KIP1 ) was *down-regulated* and cyclin E accumulated in the inactive form . Negative_regulation IFI27 CDK2 12871207 1142270 The induction of the premature senescence programme is mediated by inhibition of kinase activity , and [p27] ( KIP1 ) is *required* to maintain the senescent phenotype . Negative_regulation IFI27 CDK2 16230398 1470083 Using dominant negative Cdk2 and a degradation stable p27 mutant , we show that cell cycle progression induced by SF/HGF requires function and [p27] *inhibition* . Negative_regulation IFI27 CDK2 20661261 2334997 We also show that baicalin induced growth inhibition is associated with a decrease in cyclin activation and *increase* in [p27] level in PDGF stimulated VSMCs , which appears to be at least partly mediated by blockade of PDGF receptor ß ( PDGFRß ) -extracellular signal regulated kinase 1/2 ( ERK1/2 ) signaling . Negative_regulation IFI27 CDK2 23497867 2756590 The results show that regarding cell cycle related proteins , three types of polysaccharides significantly *enhance* the expression of [p27] ( Kip ) in HepG2 and Bel-7404 cells , while suppressing the activity of cyclin D1/CDK4 and/or . Negative_regulation IFI27 CDK4 10383891 624679 Under these conditions , CDK2 and protein expression remained unchanged compared with proliferating cells , but expression of cyclin D1 and [p27] ( KIP1 ) was *down-regulated* and cyclin E accumulated in the inactive form . Negative_regulation IFI27 CDK4 14597415 1160651 In the presence of TSH , transforming growth factor beta ( TGFbeta ) did not affect the assembly of cyclin D3-CDK4 , but it strongly inhibited the pRb-kinase activity associated with both cyclin D3 and p27 , not only by preventing the nuclear import of cyclin D3-CDK4 and its binding to [p27] , but also by *inhibiting* phosphorylation within residual p27 bound cyclin D3-CDK4 complexes . Negative_regulation IFI27 CDK4 23497867 2756591 The results show that regarding cell cycle related proteins , three types of polysaccharides significantly *enhance* the expression of [p27] ( Kip ) in HepG2 and Bel-7404 cells , while suppressing the activity of cyclin and/or cyclin E/CDK2 . Negative_regulation IFI27 CDKN1A 10362586 620061 With differentiation , p21 and p27 were strongly induced , but with different kinetics : the increase was rapid but transient and the [p27] increase was *delayed* but sustained . Negative_regulation IFI27 CDKN1A 11145574 780303 and 5 ) SMS suppresses mitogen induced [p27] ( Kip1 ) down-regulation , as well as marginally *induces* ( Cip ) expression . Negative_regulation IFI27 CDKN1A 12466968 1022424 Collectively , our data suggest that ( Cip1 ) suppresses tumor formation elicited by multiple agents and that p21 ( Cip1 ) and [p27] ( Kip1 ) *suppress* tumor formation in different ways . Negative_regulation IFI27 CDKN1A 16400524 1494644 In Western blot analysis , p21 induced cytoplasmic translocation of> ( p21 ) and p27/Kip1 ( [p27] ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation IFI27 CDKN1B 18583941 1953338 Roles of cyclin dependent kinase *inhibitors* , p21/Cip1 ( p21 ) and ( [p27] ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation IFI27 CIB1 10454569 637997 Elevated cyclin E levels , inactive retinoblastoma protein , and suppression of the [p27] ( ) *inhibitor* characterize early development of promyeloid cells into macrophages . Negative_regulation IFI27 CIB1 10903422 712907 Moreover , the inhibition of cdk activity also correlated with an increase in the expression of the [p27] ( ) cdk *inhibitor* and in its association with the cyclin-cdk2 complexes . Negative_regulation IFI27 CIB1 11404411 825496 We have found that the [p27] ( ) cyclin kinase *inhibitor* regulates progenitor cell proliferation throughout retinal histogenesis . Negative_regulation IFI27 CIB1 12482975 1032792 HGF treatment of HepG2 human hepatocellular carcinoma cells induces cell migration concomitant with increased levels of the [p27] ( ) cyclin-cdk *inhibitor* . Negative_regulation IFI27 CIB1 16869759 1496864 Cdk2 is also dispensable for cell cycle inhibition and tumor suppression by the Cip/Kip *inhibitors* , p21 ( Cip1 ) and [p27] ( ) . Negative_regulation IFI27 CIB1 18339899 1904986 These effects are mediated by nuclear accumulation of the [p27] ( ) *inhibitor* induced by down-regulation of the p45 ( Skp2 ) and Cks1 proteins , which target p27 ( Kip1 ) for degradation . Negative_regulation IFI27 CKS1B 22017545 2498876 These data suggest that both Skp2 and are up-regulated by the TNFa-RelB/p52 pathway in the early stages of renal damage and are collaboratively *involved* in down-regulation of [p27] in proliferative tubular dilation and the progression of chronic nephropathy . Negative_regulation IFI27 CUL1 19112177 2036821 Taken together , our findings indicate that HINT1 up-regulates cellular levels of p27 ( KIP1 ) by two mechanisms : 1 ) it inhibits its ubiquitylation by targeting the ( SKP2 ) ubiquitin ligase complex , and 2 ) it *inhibits* the phosphorylation of [p27] ( KIP1 ) by Src via inhibiting Src expression . Negative_regulation IFI27 CUL1 19258007 2051171 *down-regulated* the expression of [p27KIP1] and pro-apoptotic factors such as Bim , Bad , and Bax , and this activity was reversed by LY 294002 . Negative_regulation IFI27 CUL4A 16467204 1561404 These findings indicate that a Cul4A ubiquitin ligase positively regulates proliferation by targeting p27 for degradation and that down-regulation during terminal erythroid differentiation *allows* [p27] to accumulate and signal cell cycle exit . Negative_regulation IFI27 CXCL10 15988033 1429264 In the characterization of the IP10 induced apoptotic pathway , we found that overexpression of upregulated p53 and *resulted* in altered expression of p53-responsive genes such as the p21Cip1 , [p27kip1] , NF-kappaB , Bax , and PUMA genes and the mitochondrial translocation of Bax . Negative_regulation IFI27 CYCS 20724915 2313059 Concurrent with the late G1 arrest , we observed an overexpression of [p27] along with a decreased expression of p21 , cyclin dependent kinase 1 , cyclin dependent kinase 4 , and cyclin D. Clotrimazole *induced* the translocation of mitochondrial bound hexokinase II to the cytoplasm and the release of into the cytoplasm . Negative_regulation IFI27 DUSP6 11031257 809370 Overexpression in RPMI-SE cells of either a kinase negative form of MEK1 or wild-type also *induced* up-regulation of [p27] ( Kip1 ) . Negative_regulation IFI27 E2F1 10417394 631602 overexpression in cardiomyocytes *induces* downregulation of p21CIP1 and [p27KIP1] and release of active cyclin dependent kinases in the presence of insulin-like growth factor I . Negative_regulation IFI27 E2F1 10516095 652241 In both cell types , expression of ras resulted in an increase of basal and serum stimulated *dependent* transcriptional activity and a reduction in [p27] ( Kip1 ) protein levels as well . Negative_regulation IFI27 E2F2 10516095 652242 In both cell types , expression of ras resulted in an increase of basal and serum stimulated *dependent* transcriptional activity and a reduction in [p27] ( Kip1 ) protein levels as well . Negative_regulation IFI27 E2F3 10516095 652243 In both cell types , expression of ras resulted in an increase of basal and serum stimulated *dependent* transcriptional activity and a reduction in [p27] ( Kip1 ) protein levels as well . Negative_regulation IFI27 E2F4 10516095 652244 In both cell types , expression of ras resulted in an increase of basal and serum stimulated *dependent* transcriptional activity and a reduction in [p27] ( Kip1 ) protein levels as well . Negative_regulation IFI27 E2F5 10516095 652245 In both cell types , expression of ras resulted in an increase of basal and serum stimulated *dependent* transcriptional activity and a reduction in [p27] ( Kip1 ) protein levels as well . Negative_regulation IFI27 E2F6 10516095 652246 In both cell types , expression of ras resulted in an increase of basal and serum stimulated *dependent* transcriptional activity and a reduction in [p27] ( Kip1 ) protein levels as well . Negative_regulation IFI27 E2F7 10516095 652239 In both cell types , expression of ras resulted in an increase of basal and serum stimulated *dependent* transcriptional activity and a reduction in [p27] ( Kip1 ) protein levels as well . Negative_regulation IFI27 E2F8 10516095 652240 In both cell types , expression of ras resulted in an increase of basal and serum stimulated *dependent* transcriptional activity and a reduction in [p27] ( Kip1 ) protein levels as well . Negative_regulation IFI27 EFNB3 23303128 2725897 Moreover , silencing of in combination with IR caused a decrease in IR-mediated G ( 2 ) -arrest , induced cellular senescence , inhibited MAPK ERK and p38 phosphorylation , and *caused* an upregulation of [p27] ( kip1 ) expression . Negative_regulation IFI27 EGF 8816905 384471 In support of this hypothesis , TGF-beta prevents EGF induced upregulation of cyclin D1 levels , while TGF-beta is still able to induce [p27] down-regulation even in the *presence* of . Negative_regulation IFI27 EGFR 12187077 979806 These results suggested that the antiproliferative effect of blockade by mAb225 in oral SCC may be *mediated* by [p27] ( KIP1 ) and p15(INK4B) . Negative_regulation IFI27 EGFR 8706005 376266 These studies demonstrate that the antiproliferative effect of blockade in DU145 cells may be *mediated* by up-regulation of [p27KIP1] at both the mRNA and protein levels . Negative_regulation IFI27 EPHB2 19158484 2027283 Inhibition of [p27] ( Kip1 ) gene expression by PDGF *required* protein synthesis and histone deacetylase activity but not Akt or activity . Negative_regulation IFI27 ERBB2 10859299 715260 These results reveal that signals *reduce* [p27] stability and thus present potential points for therapeutic intervention in HER-2/neu associated cancers . Negative_regulation IFI27 ERBB2 23364537 2770699 Moreover , the downregulation of and PTK6 *led* to an induction of [p27] , and the dual knockdown significantly diminished cell proliferation in JIMT-1 and T47D cells . Negative_regulation IFI27 ESR1 19890043 2165926 Interestingly , overexpression of in WT276 cells *increased* the expression of [Ifi202] and stimulated the activity of the 202-luc-reporter through the c-Jun/AP-1 DNA binding site . Negative_regulation IFI27 FLI1 14871979 1208384 These data strongly suggest might *attenuate* [p27] protein level via activation of the proteasome mediated degradation pathway . Negative_regulation IFI27 FLI1 17786311 1790927 We have reported that *inhibits* p21 ( waf1/cip1 ) and [p27] ( kip1 ) expressions , which are degraded by the ubiquitin-proteasome pathway . Negative_regulation IFI27 FLI1 18271016 1911575 In this report , we show that depletion of in Ewing 's cell lines *results* in a senescence phenotype , a marked increase in expression of the G1/S regulatory proteins [p27] ( kip1 ) and p57(kip2) , and a significant decrease in cyclin D1 and CDK2 . Negative_regulation IFI27 FOXO1 21179458 2358282 The inhibition of PI3K/AKT pathway *induced* transcriptional activity resulting in induction of Bim , TRAIL , [p27/KIP1] , DR4 and DR5 , and inhibition of cyclin D1 . Negative_regulation IFI27 FOXO3 18256550 1877303 Induced expression of an active form of *resulted* in increased [p27] ( Kip1 ) expression in this cell line . Negative_regulation IFI27 FOXO3 21179458 2358283 The inhibition of PI3K/AKT pathway *induced* transcriptional activity resulting in induction of Bim , TRAIL , [p27/KIP1] , DR4 and DR5 , and inhibition of cyclin D1 . Negative_regulation IFI27 FOXO3 24441545 2922793 Mechanisms in cardiac fibroblast growth : an obligate *role* for Skp2 and in ERK1/2 MAPK dependent regulation of [p27kip1] . Negative_regulation IFI27 FOXO4 21179458 2358284 The inhibition of PI3K/AKT pathway *induced* transcriptional activity resulting in induction of Bim , TRAIL , [p27/KIP1] , DR4 and DR5 , and inhibition of cyclin D1 . Negative_regulation IFI27 FOXO6 21179458 2358281 The inhibition of PI3K/AKT pathway *induced* transcriptional activity resulting in induction of Bim , TRAIL , [p27/KIP1] , DR4 and DR5 , and inhibition of cyclin D1 . Negative_regulation IFI27 GP2 21108033 2377470 With regard to cell cycle related proteins , UDN ( 50 µg/ml ) significantly *suppressed* the expression of p53 , p21 , and [p27] , whereas it enhanced activity of cyclin D1/CDK4 . Negative_regulation IFI27 GP5 21108033 2377471 With regard to cell cycle related proteins , UDN ( 50 µg/ml ) significantly *suppressed* the expression of p53 , p21 , and [p27] , whereas it enhanced activity of cyclin D1/CDK4 . Negative_regulation IFI27 GP6 21108033 2377469 With regard to cell cycle related proteins , UDN ( 50 µg/ml ) significantly *suppressed* the expression of p53 , p21 , and [p27] , whereas it enhanced activity of cyclin D1/CDK4 . Negative_regulation IFI27 GP9 21108033 2377472 With regard to cell cycle related proteins , UDN ( 50 µg/ml ) significantly *suppressed* the expression of p53 , p21 , and [p27] , whereas it enhanced activity of cyclin D1/CDK4 . Negative_regulation IFI27 HDAC1 19158484 2027287 Inhibition of [p27] ( Kip1 ) gene expression by PDGF *required* protein synthesis and activity but not Akt or ERK activity . Negative_regulation IFI27 HDAC10 19158484 2027281 Inhibition of [p27] ( Kip1 ) gene expression by PDGF *required* protein synthesis and activity but not Akt or ERK activity . Negative_regulation IFI27 HDAC11 19158484 2027282 Inhibition of [p27] ( Kip1 ) gene expression by PDGF *required* protein synthesis and activity but not Akt or ERK activity . Negative_regulation IFI27 HDAC2 19158484 2027288 Inhibition of [p27] ( Kip1 ) gene expression by PDGF *required* protein synthesis and activity but not Akt or ERK activity . Negative_regulation IFI27 HDAC3 19158484 2027289 Inhibition of [p27] ( Kip1 ) gene expression by PDGF *required* protein synthesis and activity but not Akt or ERK activity . Negative_regulation IFI27 HDAC4 19158484 2027276 Inhibition of [p27] ( Kip1 ) gene expression by PDGF *required* protein synthesis and activity but not Akt or ERK activity . Negative_regulation IFI27 HDAC5 19158484 2027280 Inhibition of [p27] ( Kip1 ) gene expression by PDGF *required* protein synthesis and activity but not Akt or ERK activity . Negative_regulation IFI27 HDAC6 19158484 2027277 Inhibition of [p27] ( Kip1 ) gene expression by PDGF *required* protein synthesis and activity but not Akt or ERK activity . Negative_regulation IFI27 HDAC7 19158484 2027279 Inhibition of [p27] ( Kip1 ) gene expression by PDGF *required* protein synthesis and activity but not Akt or ERK activity . Negative_regulation IFI27 HDAC8 19158484 2027275 Inhibition of [p27] ( Kip1 ) gene expression by PDGF *required* protein synthesis and activity but not Akt or ERK activity . Negative_regulation IFI27 HDAC9 19158484 2027278 Inhibition of [p27] ( Kip1 ) gene expression by PDGF *required* protein synthesis and activity but not Akt or ERK activity . Negative_regulation IFI27 HK2 20724915 2313060 Concurrent with the late G1 arrest , we observed an overexpression of [p27] along with a decreased expression of p21 , cyclin dependent kinase 1 , cyclin dependent kinase 4 , and cyclin D. Clotrimazole *induced* the translocation of mitochondrial bound to the cytoplasm and the release of cytochrome c into the cytoplasm . Negative_regulation IFI27 HMOX1 12933701 1143180 The addition of tin-mesoporphyrin ( SnMP ) , an inhibitor of HO activity , reversed the *mediated* decrease of p21 and [p27] in cells overexpressing HO-1 . Negative_regulation IFI27 HRAS 14657670 1188540 In this report , using two distinct inhibitors specific for PAK1-3 ( CEP-1347 and WR-PAK18 ) , we present the first evidence indicating that the PIX/Rac/CDC42 dependent Ser/Thr kinases PAK1-3 , acting downstream of PI-3 kinase and upstream of the Raf/MEK/ERKs kinase cascade , is essential for *induced* upregulation of cyclin D1 , but not downregulation of [p27] . Negative_regulation IFI27 HRAS 9199319 438896 Analysis of Cdk-cyclin complexes indicates that signaling is *required* both for induction of cyclin D1 and for downregulation of the Cdk inhibitor [p27KIP1] . Negative_regulation IFI27 ID3 23022473 2716369 Blockade of EGFR signaling promotes glioma stem-like cell invasiveness by abolishing *mediated* inhibition of [p27] ( KIP1 ) and MMP3 expression . Negative_regulation IFI27 ID3 23022473 2716373 Together , our findings show that EGFR inhibition induces GSC invasiveness by abolishing *mediated* inhibition of [p27] ( KIP1 ) and MMP3 expression . Negative_regulation IFI27 IGF1 10417394 631603 E2F-1 overexpression in cardiomyocytes induces downregulation of p21CIP1 and [p27KIP1] and release of active cyclin dependent kinases in the *presence* of . Negative_regulation IFI27 IGF1 11376126 818176 Whereas increases p21 expression and *reduces* [p27] expression , oestradiol has no effect on p21 . Negative_regulation IFI27 IGF1 14648698 1188347 We also found that the decrease in [p27] ( Kip1 ) *induced* by was accompanied by an increase in expression of Skp2 , which is a ubiquitin ligase for p27 ( Kip1 ) , and by increased Skp2 association with p27 ( Kip1 ) . Negative_regulation IFI27 IGF1 14648698 1188348 Finally , specific inhibitors of MAPK and PI3K suggest that the *mediated* reduction in [p27] ( Kip1 ) protein level by increased degradation predominantly involves the PI3K pathway . Negative_regulation IFI27 IL1B 12171790 974224 *inhibits* expression of p21 ( WAF1/CIP1 ) and [p27] ( KIP1 ) and enhances proliferation in response to platelet derived growth factor-BB in smooth muscle cells . Negative_regulation IFI27 IL2 16020508 1465840 induced sustained increase of cyclin E and cyclin A and *prevented* up-regulation of [p27kip1] . Negative_regulation IFI27 ILK 12642872 1069473 Inhibition of by a pharmacological inhibitor *results* in inhibition of cell proliferation , PKB/Akt phosphorylation and increase of [p27] ( Kip1 ) . Negative_regulation IFI27 KRAS 14657670 1188541 In this report , using two distinct inhibitors specific for PAK1-3 ( CEP-1347 and WR-PAK18 ) , we present the first evidence indicating that the PIX/Rac/CDC42 dependent Ser/Thr kinases PAK1-3 , acting downstream of PI-3 kinase and upstream of the Raf/MEK/ERKs kinase cascade , is essential for *induced* upregulation of cyclin D1 , but not downregulation of [p27] . Negative_regulation IFI27 KRAS 9199319 438897 Analysis of Cdk-cyclin complexes indicates that signaling is *required* both for induction of cyclin D1 and for downregulation of the Cdk inhibitor [p27KIP1] . Negative_regulation IFI27 MALT1 19112177 2036822 Taken together , our findings indicate that HINT1 up-regulates cellular levels of p27 ( KIP1 ) by two mechanisms : 1 ) it inhibits its ubiquitylation by targeting the SCF ( SKP2 ) , and 2 ) it *inhibits* the phosphorylation of [p27] ( KIP1 ) by Src via inhibiting Src expression . Negative_regulation IFI27 MAP2K1 11031257 809371 Overexpression in RPMI-SE cells of either a kinase negative form of or wild-type MAP kinase phosphatase-3 also *induced* up-regulation of [p27] ( Kip1 ) . Negative_regulation IFI27 MAPK1 15939921 1440461 while phosphorylation of was inhibited in both tissues , gefitinib treatment *induced* [p27] and a decrease in Ki67 in skin but not in tumors . Negative_regulation IFI27 MAPK1 16847309 1625330 inhibition by DHA did not *increase* [p27] ( Kip1 ) mRNA levels . Negative_regulation IFI27 MAPK10 15939921 1440462 while phosphorylation of was inhibited in both tissues , gefitinib treatment *induced* [p27] and a decrease in Ki67 in skin but not in tumors . Negative_regulation IFI27 MAPK10 16847309 1625331 inhibition by DHA did not *increase* [p27] ( Kip1 ) mRNA levels . Negative_regulation IFI27 MAPK11 15939921 1440463 while phosphorylation of was inhibited in both tissues , gefitinib treatment *induced* [p27] and a decrease in Ki67 in skin but not in tumors . Negative_regulation IFI27 MAPK11 16847309 1625332 inhibition by DHA did not *increase* [p27] ( Kip1 ) mRNA levels . Negative_regulation IFI27 MAPK12 15939921 1440464 while phosphorylation of was inhibited in both tissues , gefitinib treatment *induced* [p27] and a decrease in Ki67 in skin but not in tumors . Negative_regulation IFI27 MAPK12 16847309 1625333 inhibition by DHA did not *increase* [p27] ( Kip1 ) mRNA levels . Negative_regulation IFI27 MAPK13 15939921 1440465 while phosphorylation of was inhibited in both tissues , gefitinib treatment *induced* [p27] and a decrease in Ki67 in skin but not in tumors . Negative_regulation IFI27 MAPK13 16847309 1625334 inhibition by DHA did not *increase* [p27] ( Kip1 ) mRNA levels . Negative_regulation IFI27 MAPK14 15939921 1440466 while phosphorylation of was inhibited in both tissues , gefitinib treatment *induced* [p27] and a decrease in Ki67 in skin but not in tumors . Negative_regulation IFI27 MAPK14 16847309 1625335 inhibition by DHA did not *increase* [p27] ( Kip1 ) mRNA levels . Negative_regulation IFI27 MAPK15 15939921 1440460 while phosphorylation of was inhibited in both tissues , gefitinib treatment *induced* [p27] and a decrease in Ki67 in skin but not in tumors . Negative_regulation IFI27 MAPK15 16847309 1625329 inhibition by DHA did not *increase* [p27] ( Kip1 ) mRNA levels . Negative_regulation IFI27 MAPK3 15939921 1440467 while phosphorylation of was inhibited in both tissues , gefitinib treatment *induced* [p27] and a decrease in Ki67 in skin but not in tumors . Negative_regulation IFI27 MAPK3 16847309 1625336 inhibition by DHA did not *increase* [p27] ( Kip1 ) mRNA levels . Negative_regulation IFI27 MAPK4 15939921 1440468 while phosphorylation of was inhibited in both tissues , gefitinib treatment *induced* [p27] and a decrease in Ki67 in skin but not in tumors . Negative_regulation IFI27 MAPK4 16847309 1625337 inhibition by DHA did not *increase* [p27] ( Kip1 ) mRNA levels . Negative_regulation IFI27 MAPK6 15939921 1440469 while phosphorylation of was inhibited in both tissues , gefitinib treatment *induced* [p27] and a decrease in Ki67 in skin but not in tumors . Negative_regulation IFI27 MAPK6 16847309 1625338 inhibition by DHA did not *increase* [p27] ( Kip1 ) mRNA levels . Negative_regulation IFI27 MAPK7 15939921 1440470 while phosphorylation of was inhibited in both tissues , gefitinib treatment *induced* [p27] and a decrease in Ki67 in skin but not in tumors . Negative_regulation IFI27 MAPK7 16847309 1625339 inhibition by DHA did not *increase* [p27] ( Kip1 ) mRNA levels . Negative_regulation IFI27 MAPK8 15939921 1440471 while phosphorylation of was inhibited in both tissues , gefitinib treatment *induced* [p27] and a decrease in Ki67 in skin but not in tumors . Negative_regulation IFI27 MAPK8 16847309 1625340 inhibition by DHA did not *increase* [p27] ( Kip1 ) mRNA levels . Negative_regulation IFI27 MAPK9 15939921 1440472 while phosphorylation of was inhibited in both tissues , gefitinib treatment *induced* [p27] and a decrease in Ki67 in skin but not in tumors . Negative_regulation IFI27 MAPK9 16847309 1625341 inhibition by DHA did not *increase* [p27] ( Kip1 ) mRNA levels . Negative_regulation IFI27 MICE 18544709 1952247 treated with exendin-4 showed increased beta-cell proliferation , elevated islet protein levels of cyclin A2 with unchanged D-type cyclins , elevated PDX-1 and Skp2 levels , and *reduced* [p27] levels . Negative_regulation IFI27 MSRB3 24583268 2929593 In addition , deficiency *enhanced* the protein level of [p27] , another cell cycle regulator , and caused cell cycle arrest at the G1 stage . Negative_regulation IFI27 MTDH 19304953 2064350 Moreover , we demonstrated that the upregulation of could *reduce* the expression of [p27] ( Kip1 ) and induce the expression of cyclin D1 through the AKT/FOXO3a pathway . Negative_regulation IFI27 MYCN 12700651 1082052 Retinoic acid decreases targeting of p27 for degradation via an *dependent* decrease in [p27] phosphorylation and an N-myc independent decrease in Skp2 . Negative_regulation IFI27 MYLIP 22448917 2658253 Overexpression of also *led* to altered expression of [p27] ( Kip1 ) and proliferating cell nuclear antigen , abnormal cell cycle arrest , decreased cell proliferation , migration and invasion in vitro in cell cultures , and suppressed xenograft tumor growth in vivo in the nude mouse . Negative_regulation IFI27 MYLIP 23660406 2796032 Furthermore , overexpression of *upregulates* p21 and [p27] but downregulates cdc2 and Cyclin D1 protein levels . Negative_regulation IFI27 MYLIP 24973709 2952524 Overexpression of inhibited cell growth arrest at G2/M phase , suppressed the protein levels of cyclin A and *up-regulated* the expression levels of [p27] through decreasing the levels of Fbxw8 . Negative_regulation IFI27 NCOA3 18583941 1953339 Roles of cyclin dependent kinase *inhibitors* , ( p21 ) and p27/Kip1 ( [p27] ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation IFI27 NPY6R 18816901 1970214 TMS induced activation of protein *inhibited* Akt phosphorylation and [p27] ( kip1 ) expression , indicating that PP2A is involved in the induction of p27 ( kip1 ) via Akt inhibition . Negative_regulation IFI27 NR4A1 10723574 677424 Inducible expression of the [p27KIP1] cyclin dependent kinase (CDK) *inhibitor* , the orphan nuclear receptor and the angiogenic inducer Cyr61 has also been demonstrated . Negative_regulation IFI27 NRAS 14657670 1188542 In this report , using two distinct inhibitors specific for PAK1-3 ( CEP-1347 and WR-PAK18 ) , we present the first evidence indicating that the PIX/Rac/CDC42 dependent Ser/Thr kinases PAK1-3 , acting downstream of PI-3 kinase and upstream of the Raf/MEK/ERKs kinase cascade , is essential for *induced* upregulation of cyclin D1 , but not downregulation of [p27] . Negative_regulation IFI27 NRAS 9199319 438898 Analysis of Cdk-cyclin complexes indicates that signaling is *required* both for induction of cyclin D1 and for downregulation of the Cdk inhibitor [p27KIP1] . Negative_regulation IFI27 PCNA 14627710 1201100 On the other hand , JDP2 was shown to partially transform chicken embryo fibroblast and was identified in a screen for oncogenes able to collaborate with the loss of [p27kip] *dependent* inhibitor to induce lymphomas . Negative_regulation IFI27 PCNA 15073847 1232823 The essential *role* of in Skp2 dependent [p27] degradation was recently discovered , but its role in human malignancies is unknown . Negative_regulation IFI27 PCNA 20661261 2334998 We also show that baicalin induced growth inhibition is associated with a decrease in E-CDK2 activation and *increase* in [p27] level in PDGF stimulated VSMCs , which appears to be at least partly mediated by blockade of PDGF receptor ß ( PDGFRß ) -extracellular signal regulated kinase 1/2 ( ERK1/2 ) signaling . Negative_regulation IFI27 PCNA 23219869 2763753 N-POMC1-28 increases D expression and *inhibits* [P27] ( kip1 ) in the adrenal cortex . Negative_regulation IFI27 PDGFB 10662779 665184 Importantly , the *repression* of [p27] ( Kip1 ) synthesis by was associated with a marked attenuation of Kip1 gene transcription and a corresponding decrease in Kip1 mRNA accumulation . Negative_regulation IFI27 PDGFB 15961397 1440781 PDGF-BB , tumor necrosis factor-alpha , and insulin-like growth factor 1 treatment resulted in the nuclear exclusion of FoxO , whereas alone *down-regulated* the FoxO target gene , [p27] ( kip1 ) , and enhanced cell survival and progression through the cell cycle . Negative_regulation IFI27 PIK3C3 20823108 2336477 Western blot analysis revealed that honokiol : ( i ) inhibited the levels of cyclins D1 , D2 and E and associated cyclin dependent kinases (CDKs)2 , CDK4 and CDK6 , ( ii ) upregulated Cip/p21 and [Kip/p27] and ( iii ) *inhibited* the levels of and the phosphorylation of Akt at Ser ( 473 ) in UVB induced skin tumors . Negative_regulation IFI27 PIK3CA 16706195 1496613 Inhibition of *leads* to [p27] ( Kip1 ) accumulation and cell cycle arrest , consequently . Negative_regulation IFI27 PIK3R1 16706195 1496614 Inhibition of *leads* to [p27] ( Kip1 ) accumulation and cell cycle arrest , consequently . Negative_regulation IFI27 PIK3R4 20823108 2336478 Western blot analysis revealed that honokiol : ( i ) inhibited the levels of cyclins D1 , D2 and E and associated cyclin dependent kinases (CDKs)2 , CDK4 and CDK6 , ( ii ) upregulated Cip/p21 and [Kip/p27] and ( iii ) *inhibited* the levels of and the phosphorylation of Akt at Ser ( 473 ) in UVB induced skin tumors . Negative_regulation IFI27 PIM1 18593906 1931459 In contrast , inhibition of signaling by expressing the dominant negative form of Pim1 *increased* nuclear [p27] ( Kip1 ) level and attenuated cell proliferation . Negative_regulation IFI27 PKN1 14657670 1188543 In this report , using two distinct inhibitors specific for PAK1-3 ( CEP-1347 and WR-PAK18 ) , we present the first evidence indicating that the PIX/Rac/CDC42 dependent Ser/Thr kinases , acting downstream of PI-3 kinase and upstream of the Raf/MEK/ERKs kinase cascade , is *essential* for RAS induced upregulation of cyclin D1 , but not downregulation of [p27] . Negative_regulation IFI27 POLDIP2 18212528 1863960 Inhibition of *leads* to down regulation of [p27] ( Kip1 ) , cell cycle progress and loss of regulatory T cell function . Negative_regulation IFI27 POMC 23219869 2763754 increases cyclin D expression and *inhibits* [P27] ( kip1 ) in the adrenal cortex . Negative_regulation IFI27 PTK6 23364537 2770700 Moreover , the downregulation of HER2 and *led* to an induction of [p27] , and the dual knockdown significantly diminished cell proliferation in JIMT-1 and T47D cells . Negative_regulation IFI27 RB1 18544045 2059226 Silencing the PTEN gene by siRNA transfection of IMA SMCs significantly induced the expression of and *inhibited* [p27] expression , while , the expression levels of cyclin E , pRb , p21 and p27 were unaffected by the silencing of PTEN in SV SMCs . Negative_regulation IFI27 RHOA 18180298 1875793 Cyclin D1 is an important cell cycle regulator , but in cancer its overexpression also increases cellular migration mediated by [p27] KIP1 stabilization and *inhibition* . Negative_regulation IFI27 S100A8 20934114 2332730 In this study , we try to determine *roles* of ( + ) strain in activating PI3K/Akt1 signaling pathway , and affecting expression of p21 ( WAF1/CIP1 ) and [p27] ( KIP1 ) , and also in releasing IL-8 in host cells . Negative_regulation IFI27 S100A8 23576572 2827696 H. pylori and *inhibited* the expression of [p27] ( Kip1 ) ( CDKN1B ) and promoted cell proliferation by upregulating FoxM1 . Negative_regulation IFI27 SERPINF1 17525281 1746227 *down-regulated* G ( 1 ) cyclins and up-regulated [p27] levels in platelet derived growth factor-BB exposed SMCs as well . Negative_regulation IFI27 SHARPIN 24506958 2886187 Silence of caused inactivation of AKT signaling and *up-regulated* expression of [P27] ( Kip1 ) and P21 ( Cip1 ) proteins . Negative_regulation IFI27 SKP1 19112177 2036816 Taken together , our findings indicate that HINT1 up-regulates cellular levels of p27 ( KIP1 ) by two mechanisms : 1 ) it inhibits its ubiquitylation by targeting the ( SKP2 ) ubiquitin ligase complex , and 2 ) it *inhibits* the phosphorylation of [p27] ( KIP1 ) by Src via inhibiting Src expression . Negative_regulation IFI27 SKP1 19258007 2051169 *down-regulated* the expression of [p27KIP1] and pro-apoptotic factors such as Bim , Bad , and Bax , and this activity was reversed by LY 294002 . Negative_regulation IFI27 SKP2 15631990 1362357 Ectopic expression of *restores* [p27] down-regulation and DNA synthesis to the levels observed in parental cells , whereas inactivation of Skp2 abrogates the inhibitory effect of p107 on S phase entry . Negative_regulation IFI27 SKP2 16424012 1515377 Furthermore , not only the knockdown of p27 , but also the forced expression of , *reduced* the expression levels of [p27] protein and partially rescued senescence-like phenotype caused by EWS-Fli1 targeting siRNAs . Negative_regulation IFI27 SKP2 16618721 1551046 Additionally , p27 levels in MYCN overexpressing cells were restored by treatment with Skp2 small interfering RNA , indicating that down-regulation of [p27] by MYCN was *due* to high expression of . Negative_regulation IFI27 SKP2 22017545 2498875 These data suggest that both and Cks1 are up-regulated by the TNFa-RelB/p52 pathway in the early stages of renal damage and are collaboratively *involved* in down-regulation of [p27] in proliferative tubular dilation and the progression of chronic nephropathy . Negative_regulation IFI27 SKP2 24441545 2922792 Mechanisms in cardiac fibroblast growth : an obligate *role* for and FOXO3a in ERK1/2 MAPK dependent regulation of [p27kip1] . Negative_regulation IFI27 SMAD1 21847367 2468645 Increasing TßRIII expression in colon cancer model systems enhanced ligand mediated phosphorylation of p38 and the proteins , while switching TGF-ß and BMP-2 from inhibitors to stimulators of colon cancer cell proliferation , *inhibiting* ligand induced p21 and [p27] expression . Negative_regulation IFI27 SMAD2 21847367 2468646 Increasing TßRIII expression in colon cancer model systems enhanced ligand mediated phosphorylation of p38 and the proteins , while switching TGF-ß and BMP-2 from inhibitors to stimulators of colon cancer cell proliferation , *inhibiting* ligand induced p21 and [p27] expression . Negative_regulation IFI27 SMAD3 21847367 2468647 Increasing TßRIII expression in colon cancer model systems enhanced ligand mediated phosphorylation of p38 and the proteins , while switching TGF-ß and BMP-2 from inhibitors to stimulators of colon cancer cell proliferation , *inhibiting* ligand induced p21 and [p27] expression . Negative_regulation IFI27 SMAD4 21847367 2468648 Increasing TßRIII expression in colon cancer model systems enhanced ligand mediated phosphorylation of p38 and the proteins , while switching TGF-ß and BMP-2 from inhibitors to stimulators of colon cancer cell proliferation , *inhibiting* ligand induced p21 and [p27] expression . Negative_regulation IFI27 SMAD5 21847367 2468649 Increasing TßRIII expression in colon cancer model systems enhanced ligand mediated phosphorylation of p38 and the proteins , while switching TGF-ß and BMP-2 from inhibitors to stimulators of colon cancer cell proliferation , *inhibiting* ligand induced p21 and [p27] expression . Negative_regulation IFI27 SMAD6 21847367 2468650 Increasing TßRIII expression in colon cancer model systems enhanced ligand mediated phosphorylation of p38 and the proteins , while switching TGF-ß and BMP-2 from inhibitors to stimulators of colon cancer cell proliferation , *inhibiting* ligand induced p21 and [p27] expression . Negative_regulation IFI27 SMAD7 21847367 2468651 Increasing TßRIII expression in colon cancer model systems enhanced ligand mediated phosphorylation of p38 and the proteins , while switching TGF-ß and BMP-2 from inhibitors to stimulators of colon cancer cell proliferation , *inhibiting* ligand induced p21 and [p27] expression . Negative_regulation IFI27 SMAD9 21847367 2468652 Increasing TßRIII expression in colon cancer model systems enhanced ligand mediated phosphorylation of p38 and the proteins , while switching TGF-ß and BMP-2 from inhibitors to stimulators of colon cancer cell proliferation , *inhibiting* ligand induced p21 and [p27] expression . Negative_regulation IFI27 SOCS1 19349901 2094415 Overexpression of in ECA109 cells *resulted* in decreased [p27] level and this decrease was sensitive to 26S proteasome inhibitors . Negative_regulation IFI27 SOCS1 25036402 2956650 BRSK1 is a novel tumor suppressor in breast cancer which inversely correlated with Jab1 expression , may involve in the restoring *induced* suppression of [p27] ( Kip1 ) and may regulate cell cycle through the PI3K/Akt pathway . Negative_regulation IFI27 SRC 17254967 1691046 inhibitors *increase* cellular [p27] stability , and Src overexpression accelerates p27 proteolysis . Negative_regulation IFI27 SRC 17254967 1691052 Importantly , we report that in tamoxifen-resistant breast cancer cell lines , inhibition can *increase* [p27] levels and restore tamoxifen sensitivity . Negative_regulation IFI27 SST 19706788 2183138 and SSTR1 , -2 , and -5 agonists strongly *inhibited* in vivo C6 tumor growth , intratumoral neovessel formation , Ki-67 expression , and ERK1/2 phosphorylation and induced upregulation of [p27] ( Kip1 ) , whereas only a modest activation of caspase-3 was observed . Negative_regulation IFI27 SSTR1 19706788 2183139 Somatostatin and , -2 , and -5 agonists strongly *inhibited* in vivo C6 tumor growth , intratumoral neovessel formation , Ki-67 expression , and ERK1/2 phosphorylation and induced upregulation of [p27] ( Kip1 ) , whereas only a modest activation of caspase-3 was observed . Negative_regulation IFI27 STAT5A 10951574 723720 Inhibition of MEK activation completely abrogated OSM and IL-6 induced p27kip1 accumulation , while expression of dominant negative decreased the OSM and IL-6 mediated inhibition of DNA-synthesis and partially *inhibited* [p27kip1] accumulation . Negative_regulation IFI27 TAB2 19112177 2036820 Taken together , our findings indicate that HINT1 up-regulates cellular levels of p27 ( KIP1 ) by two mechanisms : 1 ) it inhibits its ubiquitylation by targeting the SCF ( SKP2 ) , and 2 ) it *inhibits* the phosphorylation of [p27] ( KIP1 ) by Src via inhibiting Src expression . Negative_regulation IFI27 TCF12 17113786 1677094 Overexpression of the prosensory , Math1 , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , [p27Kip] , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation IFI27 TCF15 17113786 1677095 Overexpression of the prosensory , Math1 , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , [p27Kip] , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation IFI27 TCF19 17113786 1677096 Overexpression of the prosensory , Math1 , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , [p27Kip] , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation IFI27 TCF20 17113786 1677097 Overexpression of the prosensory , Math1 , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , [p27Kip] , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation IFI27 TCF21 17113786 1677098 Overexpression of the prosensory , Math1 , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , [p27Kip] , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation IFI27 TCF23 17113786 1677102 Overexpression of the prosensory , Math1 , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , [p27Kip] , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation IFI27 TCF24 17113786 1677104 Overexpression of the prosensory , Math1 , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , [p27Kip] , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation IFI27 TCF25 17113786 1677103 Overexpression of the prosensory , Math1 , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , [p27Kip] , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation IFI27 TCF3 17113786 1677099 Overexpression of the prosensory , Math1 , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , [p27Kip] , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation IFI27 TCF4 17113786 1677100 Overexpression of the prosensory , Math1 , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , [p27Kip] , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation IFI27 TCF7 17113786 1677101 Overexpression of the prosensory , Math1 , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , [p27Kip] , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation IFI27 TGFB1 10613355 575592 Up-regulation of [p27] protein expression by either TGF-beta1 or EB1089 was *reduced* by . Negative_regulation IFI27 TGFB1 9299547 453768 p21 mRNA expression was greatly *induced* by in a p53 independent mechanism , while [p27] mRNA expression was not affected by TGF-beta1 . Negative_regulation IFI27 TGFB2 11726615 884484 When cells were stained for phosphorylated p27 ( Kip1 ) , FGF-2 markedly enhanced the staining of phosphorylated p27 ( Kip1 ) in nuclei , whereas both cAMP and *prevented* the phosphorylation of [p27] ( Kip1 ) . Negative_regulation IFI27 TIMP1 15864715 1401386 Growth factors and their receptors , cell-cycle regulators , cell-adhesion molecules and matrix degrading enzymes are those to be used as prognostic factors , including epidermal growth factor (EGF) , EGF receptor , K-sam , HER-2 , interleukin (IL)-8 , vascular endothelial growth factor ( VEGF ) , cyclin E , [p27] , E-cadherin , CD44v6 , matrix metalloproteinase-1 (MMP-1) , and tissue *inhibitor* of matrix metalloproteinase-1 ( ) . Negative_regulation IFI27 TMED7 11374878 817932 [p27] ( Kip1 ) associates with cyclin/cdk complexes and inhibiting cdk activity , and overexpression of ( Kip1 ) *induces* G1 arrest . Negative_regulation IFI27 TNFSF12 19887380 2203398 Stimulation of neonatal rat cardiomyocytes with *resulted* in increased DNA synthesis , increased expression of the proliferative markers Cyclin D2 and Ki67 , and downregulation of the cell cycle inhibitor [p27KIP1] . Negative_regulation IFI27 TRAF6 19112177 2036818 Taken together , our findings indicate that HINT1 up-regulates cellular levels of p27 ( KIP1 ) by two mechanisms : 1 ) it inhibits its ubiquitylation by targeting the SCF ( SKP2 ) , and 2 ) it *inhibits* the phosphorylation of [p27] ( KIP1 ) by Src via inhibiting Src expression . Negative_regulation IFI27 TRERF1 17015480 1629440 Moreover , overexpression and knockdown , respectively , increased or *prevented* the induction of p21 and [p27] gene expression by progesterone . Negative_regulation IFI27 TXNIP 15930262 1414437 In this process , *blocked* the JAB1 mediated translocation of [p27] ( kip1 ) from the nucleus to the cytoplasm . Negative_regulation IFI27 UBE2V1 19112177 2036819 Taken together , our findings indicate that HINT1 up-regulates cellular levels of p27 ( KIP1 ) by two mechanisms : 1 ) it inhibits its ubiquitylation by targeting the SCF ( SKP2 ) , and 2 ) it *inhibits* the phosphorylation of [p27] ( KIP1 ) by Src via inhibiting Src expression . Negative_regulation IFI27 VEGFC 24184161 2889875 Flow cytometry and immunoblotting revealed that *induces* S phase accumulation through the inhibition of [p27] and the upregulation of cyclin E and cyclin dependent kinase-2 expressions . Negative_regulation IFI44 EPHB2 21518868 2428879 EGF activates NF-?B and *stimulates* phosphorylation of FER , EGF receptor (EGFR) , and ERK [p42/p44] , and decreased expression of FER or inhibition of phosphorylation inhibits the EGF induced activation of NF-?B . Negative_regulation IFI44 IL1B 12139924 969335 Regarding intracellular signaling , activated the p38 mitogen activated protein kinase (MAPK) but not the p42/p44 MAPK and , when combined with growth factors , intensified p38 activation but *inhibited* the growth-factor induced [p42/p44] activation . Negative_regulation IFI44 MAP2K6 11834245 910345 Furthermore , ( MEK)-1-specific inhibitor , 2- ( 2-amino-3-methoxyphenyl ) -4H-1-benzopyran-4-one ( PD 98059 ) , *blocked* the lipopolysaccharide induced [p44/42] ERK activation and PDGF production . Negative_regulation IFI44 TNF 10329978 613987 Furthermore , *repressed* insulin induced p42 ( MAPK ) and [p44] ( MAPK ) tyrosine phosphorylation by 81 % ( P < 0.01 ) . Negative_regulation IFN1@ OASL 23874199 2817743 Together , these results demonstrate that *mediated* negative regulation of [IFN-I] production at an early phase of infection permits viral persistence and suppresses T-cell function , suggesting that IFN-I negative regulators , including OASL1 , could be exciting new targets for preventing chronic viral infection . Negative_regulation IFN1@ TLR7 22227568 2544655 TLR2 also inhibited induction of IFN-I by , another MyD88 dependent IFN-I inducing receptor , but did not *inhibit* [IFN-I] induction by TLR3 or TLR4 ( both Toll/IL-1R domain containing adapter inducing IFN-ß dependent , MyD88 independent ) . Negative_regulation IFN1@ TLR7 24586760 2920225 The immunoglobulin-like transcript (ILT)7 is a surface receptor expressed by immature pDC , and ILT7 cross linking ( XL-ILT7 ) inhibits [IFN-I] production by pDC in *response* to and 9 stimulation . Negative_regulation IFN1@ TNF 12162875 972249 and IL-4 *inhibited* [IFN-I] production by PDC and monocytes , respectively , and IL-10 strongly inhibited IFN-I production in both cell lineages . Negative_regulation IFNA1 ADRB2 23724117 2793247 stimulation *suppresses* TLR9 dependent [IFNA1] secretion in human peripheral blood mononuclear cells . Negative_regulation IFNA1 TNF 17887935 1797417 The three herbal extracts significantly increased [interferon-alpha] production , but *inhibited* the release of and interleukin (IL)-1beta . Negative_regulation IFNA1 TNF 18050196 1833209 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Negative_regulation IFNA10 TNF 17887935 1797419 The three herbal extracts significantly increased [interferon-alpha] production , but *inhibited* the release of and interleukin (IL)-1beta . Negative_regulation IFNA10 TNF 18050196 1833210 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Negative_regulation IFNA13 TNF 17887935 1797421 The three herbal extracts significantly increased [interferon-alpha] production , but *inhibited* the release of and interleukin (IL)-1beta . Negative_regulation IFNA13 TNF 18050196 1833211 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Negative_regulation IFNA14 TNF 17887935 1797423 The three herbal extracts significantly increased [interferon-alpha] production , but *inhibited* the release of and interleukin (IL)-1beta . Negative_regulation IFNA14 TNF 18050196 1833212 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Negative_regulation IFNA16 TNF 17887935 1797425 The three herbal extracts significantly increased [interferon-alpha] production , but *inhibited* the release of and interleukin (IL)-1beta . Negative_regulation IFNA16 TNF 18050196 1833213 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Negative_regulation IFNA17 TNF 17887935 1797427 The three herbal extracts significantly increased [interferon-alpha] production , but *inhibited* the release of and interleukin (IL)-1beta . Negative_regulation IFNA17 TNF 18050196 1833214 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Negative_regulation IFNA2 TNF 17887935 1797429 The three herbal extracts significantly increased [interferon-alpha] production , but *inhibited* the release of and interleukin (IL)-1beta . Negative_regulation IFNA2 TNF 18050196 1833215 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Negative_regulation IFNA2 TNF 9208877 441007 [Interferon-alpha2b] is a potent inhibitor in vitro of the induction of IL-1 and tumor necrosis factor by IL-1 and can *induce* high circulating levels of the anti-inflammatory soluble receptor and IL-1 receptor antagonist in humans . Negative_regulation IFNA21 TNF 17887935 1797431 The three herbal extracts significantly increased [interferon-alpha] production , but *inhibited* the release of and interleukin (IL)-1beta . Negative_regulation IFNA21 TNF 18050196 1833216 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Negative_regulation IFNA4 TNF 17887935 1797433 The three herbal extracts significantly increased [interferon-alpha] production , but *inhibited* the release of and interleukin (IL)-1beta . Negative_regulation IFNA4 TNF 18050196 1833217 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Negative_regulation IFNA5 TNF 17887935 1797435 The three herbal extracts significantly increased [interferon-alpha] production , but *inhibited* the release of and interleukin (IL)-1beta . Negative_regulation IFNA5 TNF 18050196 1833218 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Negative_regulation IFNA6 TNF 17887935 1797437 The three herbal extracts significantly increased [interferon-alpha] production , but *inhibited* the release of and interleukin (IL)-1beta . Negative_regulation IFNA6 TNF 18050196 1833219 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Negative_regulation IFNA7 TNF 17887935 1797439 The three herbal extracts significantly increased [interferon-alpha] production , but *inhibited* the release of and interleukin (IL)-1beta . Negative_regulation IFNA7 TNF 18050196 1833220 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Negative_regulation IFNA8 TNF 17887935 1797441 The three herbal extracts significantly increased [interferon-alpha] production , but *inhibited* the release of and interleukin (IL)-1beta . Negative_regulation IFNA8 TNF 18050196 1833221 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Negative_regulation IFNB1 BPI 17239348 1690524 Although the functional mechanism whereby extra-cellular BPI modulates the intra-cellular signal pathways selected by the TLR adaptors , MyD88 and TICAM-1 ( TRIF ) , remains unknown , we infer that the lipid A portion of LPS participates in LBP amplified IFN-beta induction and that binding to LPS *leads* to inhibition of the activation of NF-kappaB and [IFN-beta] by LPS or agonistic lipid A via TLR4 in an extrinsic mode . Negative_regulation IFNB1 CD14 10601848 655177 Important *role* of membrane associated in the induction of [IFN-beta] and subsequent nitric oxide production by murine macrophages in response to bacterial lipopolysaccharide . Negative_regulation IFNB1 IL1B 14632664 1170693 Mitogen stimulation of embryonic day 18 and day 1 post-hatch thymocytes *induced* up-regulation of IFN-gamma , IL-1beta and TGF-beta transcripts , and down-regulation of IFN-alpha , [IFN-beta] and IL-2 transcripts , with a higher induction of IFN-gamma , and TGF-beta transcripts in more immature T-cell-receptor negative ( TCR- ) than TCR+ ( TCR1+ , TCR2+ , or TCR3+ ) subsets . Negative_regulation IFNB1 NEDD9 22427889 2573179 We found that both p50 and *inhibited* expression of [Ifnb] , and that inhibition of Ifnb by p105?N depended on ERK activation , because a mutant of p105?N ( p105?NS930A ) that lacks a key serine necessary to support ERK activation failed to inhibit . Negative_regulation IFNB1 TLR7 23234343 2757755 Stimulation of thyrocytes with ligands *resulted* in activation of the [interferon-beta] ( IFN-ß ) promoter and the nuclear factor kappa-light-chain-enhancer of activated B cells ( NF?B ) -dependent promoter . Negative_regulation IFNB1 TLR7 24956889 2947319 mediated mast cell stimulation *resulted* in cysteinyl leukotriene ( cysLT ) and [interferon (IFN)-beta] synthesis , whereas no histamine and CXCL8 secretion was stated . Negative_regulation IFNB1 TNF 16580738 1562461 [IFN-beta] suppressed the *induced* levels of secreted MMP-9 and MMP-2 , while enhancing the expression of TIMP-1 and TIMP-2 mRNA . Negative_regulation IFNB1 TNF 3262700 100052 In contrast to IL1 , did not *inhibit* [IFN-beta] synthesis , nor did it interfere with the antiviral action of IFN-beta . Negative_regulation IFNG ADRB2 15879418 1432946 Desensitization of ( - ) -isoproterenol induced cyclic adenosine monophosphate ( cAMP ) accumulation and beta(2)-adrenergic receptor sequestration and downregulation were measured in relation to *mediated* inhibition of [IFN-gamma] and interleukin-5 production . Negative_regulation IFNG ARSA 1740279 182076 <5ASA> , N-acetyl 5ASA , 4ASA , N-acetyl 4ASA , olsalazine and colchicine *reduce* [interferon-gamma] induced HLA-DR expression . Negative_regulation IFNG CD14 8163930 254569 Thus , depressed TNF synthesis , diminished expression of , and low plasma LPS binding capacity , in addition to *blocked* [IFN-gamma] signaling in the mutant mice , likely to combine to manifest in the resistant phenotype of IFN gamma R-/- mice to endotoxin . Negative_regulation IFNG EPHB2 16204085 1464038 Pharmacologic inhibition of activity , but not Jnk MAPK activity , *led* to significantly decreased [IFN-gamma] production from both SHIP1-/- and WT NK cells under these conditions . Negative_regulation IFNG EPHB2 17127048 1732209 In conclusion , ( 1 ) p38MAPK-pathway rather than ERK-pathway may play a more basic role in the regulation of the increased T-bet expression in asthma , and ( 2 ) and p38MAPK-activation modulate IFNgamma expression independently of T-bet and this regulatory role of ERK-1/-2 on [IFNgamma] release is *impaired* in asthma . Negative_regulation IFNG EPHB2 18174382 1889910 Chemical disruption of lipid rafts inhibited signaling in response to costimulation and significantly *inhibited* [IFN-gamma] production . Negative_regulation IFNG FAS 12505729 1038271 PD analyses suggested that in NHS samples containing CsA+SRL ( n=5 ) , ( 1 ) PMA-Ionomycin stimulated T-cell expression of intracellular IL-2 , TNF-alpha , and [IFN-gamma] was inhibited by CsA , and minimally by SRL , and ( 2 ) the two agents *inhibited* pokeweed mitogen ( PWM ) -stimulated B-cell expression of CD54 and , but not CD86 ( ICAM-1 , Fas antigen , and B7.2 ) , synergistically . Negative_regulation IFNG FAS 12690298 1078894 Our results indicate that [IFNgamma] *induces* overexpression of and consequently enhances the sensitivity of melanoma cells to Fas mediated apoptosis . Negative_regulation IFNG HRH1 15021962 1221736 Depletion of the *resulted* in decreases in the release of IL-2 and IL-10 from both CD4+ and CD8+ cells and increases in the release of IL-4 from CD4+ T cells and [IFN-gamma] from CD8+ cells . Negative_regulation IFNG IL1B 11920321 926084 The *role* of endogenous interleukin (IL)-18 , IL-12 , , and tumor necrosis factor-alpha in the production of [interferon-gamma] induced by Candida albicans in human whole-blood cultures . Negative_regulation IFNG IL1B 15930749 1414594 Both CHD and MCHD also potently reduced the mRNA levels of cyclooxygenase (COX)-2 , [interferon (IFN)-gamma] and IL-4 increased in oxazolone applied mouse ears , but weakly *inhibited* that of and TNF-alpha . Negative_regulation IFNG IL1B 18025126 1827591 The CCL20 production by synoviocytes is augmented in vitro by , IL-17 , or tumor necrosis factor alpha , and is *suppressed* by [IFN-gamma] or IL-4 . Negative_regulation IFNG IL1B 18805021 1987115 A synergistic *role* for and TNFalpha in monocyte derived [IFNgamma] inducing activity . Negative_regulation IFNG IL1B 7594594 325888 Stimulation of SCID mouse splenocytes with or IL-1 alpha did not result in production of IFN-gamma but *enhanced* remarkably the ability of T. gondii or IL-12 to stimulate production of [IFN-gamma] . Negative_regulation IFNG IL1B 8360333 227772 in doses ranging from 1 to 100 units/ml *inhibited* the level of [IFN-gamma] induced Ia expression on astrocytes , and this inhibition was dose dependent ( mean maximum inhibition of 53 +/- 5 % in number of positive cells and 53 +/- 2.6 % in mean fluorescence intensity in four separate experiments ) . Negative_regulation IFNG IL1B 8574153 342205 PAI was able to *induce* the production of [IFN-gamma] and TNF-alpha while that of IL-4 and was reduced . Negative_regulation IFNG IL1B 9916712 587498 *suppressed* [IFN-gamma] activation of the type IV CIITA promoter in astroglioma cells , indicating that the inhibitory influence of IL-1beta is mediated by inhibition of CIITA transcription . Negative_regulation IFNG ITGAL 11882913 919655 Essential *role* of interaction in synergistic effect of IL-18 and IL-12 on [IFN-gamma] production in human PBMC . Negative_regulation IFNG ITGAL 9036976 415228 The ability of B7 transfectants to enhance NK cell production of [IFN-gamma] was *dependent* on the intracellular adhesion interaction and could be inhibited by TGF-beta , but not IL-10 . Negative_regulation IFNG ITGB2 8757962 377785 TNF-alpha but not [IFN-gamma] was detected in the supernatant of co-culture between KC and AH70 cells , and this production was partially *inhibited* by anti-ICAM-1 and . Negative_regulation IFNG KLF9 10605024 655595 The *role* of Sp family members , basic , and E box factors in the basal and [IFN-gamma] regulated expression of the human complement C4 promoter . Negative_regulation IFNG MUC16 20220086 2237276 T cell Ig domain and domain 1 engagement on invariant NKT cells in the presence of TCR stimulation enhances IL-4 production but *inhibits* [IFN-gamma] production . Negative_regulation IFNG PECAM1 17922402 1804231 Interestingly , bound to SLAM associated protein (SAP) , an IFN- gamma inhibitor in tuberculosis , and when CD31 and SAP were coexpressed in lymphocytes , their association *inhibited* the [IFN- gamma] response to M. tuberculosis . Negative_regulation IFNG PECAM1 18466611 1916543 The early decrease of and the parallel increase of ICAM-1-expression following CCl4-treatment is *induced* by elevated levels of [IFN-gamma] in livers and may facilitate adhesion and transmigration of inflammatory cells . Negative_regulation IFNG RAB31 14734758 1199480 also *reduced* in vivo [IFN-gamma] production by > 2-fold in CpG pretreated mice . Negative_regulation IFNG SPHK1 16272312 1479404 Consistently , overexpression of dominant negative *increased* the production of IL-2 , TNF-alpha , and [IFN-gamma] in Th1 cells . Negative_regulation IFNG STAT4 10072548 594514 We examined this and found that TGF-beta1 did not have any effect on IL-12 induced phosphorylation of JAK2 , TYK2 , and although TGF-beta1 *inhibited* IL-2- and IL-12 induced [IFN-gamma] production . Negative_regulation IFNG STAT4 11120802 758225 Since the precise *role* of in [IFN-gamma] induction has not been established , experiments were conducted to examine Stat4 activation of IFN-gamma and other genes required for cytokine induced expression of IFN-gamma . Negative_regulation IFNG STAT4 11994496 939085 We then examined whether the change in IL-12 induced [IFN-gamma] production by treatment with sex hormones was *due* to the regulation of activation . Negative_regulation IFNG STAT4 12912921 1129555 However , is *required* for normal levels of IL-12 induced [interferon-gamma] production from Th1 cells . Negative_regulation IFNG STAT4 15817683 1432412 Impaired [interferon-gamma] production as a *consequence* of deficiency after autologous hematopoietic stem cell transplantation for lymphoma . Negative_regulation IFNG TLR7 15501793 1327097 Microarray gene expression studies were then used to determine whether prolonged signaling by M. tuberculosis broadly *inhibits* [IFN-gamma] regulation of macrophage gene expression . Negative_regulation IFNG TLR7 16034103 1436344 mediated activation of human NK cells *results* in accessory cell dependent [IFN-gamma] production . Negative_regulation IFNG TLR7 17918201 1819330 In this study , we investigated which mouse B cell subsets are the most potent cytokine producers , and examined the *role* of in the control of secretion of IL-6 , IL-10 , IL-12 and [IFN-gamma] by B cells . Negative_regulation IFNG TNF 10721095 579364 For example we have found that TNF-alpha *enhances* [IFN-gamma] induced IDO activity and antimicrobial effect in human glioblastoma cells whereas both IFN-gamma mediated effects were blocked by as well as by IL-1 in a human uroepithelial cell line . Negative_regulation IFNG TNF 11001546 734537 Human recombinant ( 25 ng/mL ) added during the activation culture *resulted* in a two-fold increase in [interferon-gamma] release ( type 1 response ) and a significant reduction of interleukin-10 ( type 2 response ) after tumor antigen stimulation . Negative_regulation IFNG TNF 11179286 786783 Cs given after TSST-1 also did not inhibit enhancement of LPS induced serum by TSST-1 but *inhibited* the enhancement effect of TSST-1 on LPS induced serum [IFN-gamma] by 50 % . Negative_regulation IFNG TNF 11228534 765061 IL-12 DNA administration *induces* long lasting systemic [IFN -gamma] production , whereas IL-4 and levels remained undetectable . Negative_regulation IFNG TNF 11602691 871227 Blockade of phosphodiesterase 4 with rolipram reduced the production of , interleukin (IL)-5 , IL-10 , and IL-2 but poorly *inhibited* cell proliferation and [interferon-gamma (IFN-gamma)] production by activated human T cells . Negative_regulation IFNG TNF 11920321 926082 The *role* of endogenous interleukin (IL)-18 , IL-12 , IL-1beta , and in the production of [interferon-gamma] induced by Candida albicans in human whole-blood cultures . Negative_regulation IFNG TNF 12542829 1050732 stimulation *down-regulated* [IFN-gamma] secretion and up-regulated TNF-alpha secretion . Negative_regulation IFNG TNF 12670445 1076015 Blocking endogenous IL-12 and *reduced* [IFN-gamma] production by 69 and 36 % . Negative_regulation IFNG TNF 12750172 1133899 TNF-alpha and [IFN-gamma] are overexpressed in the bone marrow of Fanconi anemia patients and *suppresses* erythropoiesis in vitro . Negative_regulation IFNG TNF 1314868 185366 Lymphocyte proliferation and production in response to the mitogen concanavalin A ( ConA ) were comparable in adults and infants , but ConA stimulated [IFN-gamma] production in infants was *diminished* throughout the study period . Negative_regulation IFNG TNF 15208038 1261744 Treatment of infected mice with pentoxifylline , known to decrease [IFN-gamma] production and to *inhibit* the gene transcription , reduced the placental production of TNF , and the fetal mortality in comparison to control animals . Negative_regulation IFNG TNF 15372109 1297793 neutralizing *reduced* [IFN-gamma] production and partially prevented dysfunction . Negative_regulation IFNG TNF 15749890 1379724 In the absence of WSX-1 , an increased production of the proinflammatory cytokines and IL-12p40 *resulted* in elevated CD4+ T cell activation and [IFN-gamma] production , which enhanced macrophage effector functions and reduced bacterial loads . Negative_regulation IFNG TNF 15914319 1412621 CGP41251 inhibited production by T cells with an IC ( 50 ) of 0.5 microM and did not significantly *inhibit* the production of IL-2 or [IFN-gamma] . Negative_regulation IFNG TNF 17266742 1691569 However , LTalpha , but not , was *necessary* for early IFNgamma production and the regulation of [IFNgamma] production later in infection . Negative_regulation IFNG TNF 17713857 1801331 Absence of *increases* the cytotoxic activity and secretion of [IFN-gamma] by IL-2 treated splenocytes and NK cells in co-cultures with MOK L2D1+/p53-/- oral tumor cells . Negative_regulation IFNG TNF 1850219 155536 Both normal and patient sera , at effective concentrations , only slightly affected the binding of <125I-TNF> to ML-1 cells , but any of these sera significantly *inhibited* the binding of [125I-IFN-gamma] to U-937 cells or to THP-1 cells . Negative_regulation IFNG TNF 18651847 1967039 At 2 h , minocycline HCl *induced* high levels of IL-10 , TNFalpha and [IFNgamma] , while CHX reduced the levels of and IFNgamma . Negative_regulation IFNG TNF 18805021 1987114 A synergistic *role* for IL-1beta and in monocyte derived [IFNgamma] inducing activity . Negative_regulation IFNG TNF 19013541 2022436 Ursolic acid *enhanced* IL-2 and [IFN-gamma] production in response to Con A stimulation , whereas it inhibited production in response to LPS stimulation . Negative_regulation IFNG TNF 1910954 167452 Carbetimer did not stimulate release from isolated normal human monocytes or lymphocytes , but it markedly *inhibited* T-lymphocyte production of [IFN-gamma] , which became undetectable at a concentration of 1 mg of Carbetimer/ml . Negative_regulation IFNG TNF 19446335 2090677 The expression of CD59 could be augmented by IL-1 beta , IL-6 and but was *suppressed* by [IFN-gamma] . Negative_regulation IFNG TNF 21438292 2361499 This Pd salt inhibited IFN-gamma , TNF-alpha , IL-10 and IL-17 release from PBMC of non-atopic women , whereas Pd nanoparticles enhanced the release of [IFN-gamma] and *inhibited* that of and IL-17 . Negative_regulation IFNG TNF 2538336 108364 Recombinant *reduced* collagen mRNA levels 2-fold and stimulated collagenase mRNA levels 5-fold , while recombinant [IFN gamma] affected only collagen mRNA levels . Negative_regulation IFNG TNF 7507414 244556 [Interferon-gamma] *induced* a weak increase in VCAM-1 mRNA expression , with no synergistic effect on the stimulation by . Negative_regulation IFNG TNF 7730628 302371 IFN-gamma synergistically enhanced TNF-alpha induced levels of IP-10 mRNA , whereas levels of JE ( MCP-1 ) or KC ( GRO/MGSA ) mRNA *induced* by were unaffected by [IFN-gamma] . Negative_regulation IFNG TNF 8163930 254568 Thus , depressed synthesis , diminished expression of CD14 , and low plasma LPS binding capacity , in addition to *blocked* [IFN-gamma] signaling in the mutant mice , likely to combine to manifest in the resistant phenotype of IFN gamma R-/- mice to endotoxin . Negative_regulation IFNG TNF 8391545 224364 did not competitively *inhibit* [125I-IFN-gamma] binding . Negative_regulation IFNG TNF 8554423 347327 Production of systemic was greater , but the [IFN-gamma] response was *diminished* in the TPN group compared with the TEN group after intraperitoneal bacterial challenge . Negative_regulation IFNG TNF 8575836 340878 The question was asked whether is *involved* in regulation of [interferon gamma (IFN gamma)] production by T cells . Negative_regulation IFNG TNF 8575836 340880 Preincubation of monocytes with rTNF *enhanced* their ability to induce [IFN gamma] production while synthesis inhibitors decreased it . Negative_regulation IFNG TNF 8779914 379941 [Interferon-gamma (IFN-gamma)] , in the *presence* of , decreases proliferation of a human salivary gland ductal cell line , HSG ( Wu , A. , R. Kurrasch , J. Katz , P. Fox , B. Baum , and J. Atkinson . Negative_regulation IFNG TNF 8932856 398035 In the MLC , a feedback mechanism between TNF-alpha and IFN-gamma exists , since *reduced* the secretion of [IFN-gamma] and anti-IFN-gamma inhibited the release of TNF-alpha . Negative_regulation IFNG TNF 9334850 457924 Further studies revealed that *enhanced* the ability of IFN-alpha/beta to stimulate production of [IFN-gamma] by NK cells . Negative_regulation IFNG TNF 9730287 530273 and TGF-beta1 *inhibited* the [IFN-gamma] induced MHC class II expression . Negative_regulation IFNG TNF 9778221 540366 also *reduced* [IFNgamma] production by T cells , indicating that TNFalpha is involved in the cellular immune response to collagen . Negative_regulation IFNG TNF 9927530 588640 We investigated the *role* of in the regulation of MHC class II antigens and cytokine mRNA expression of TNF , [interferon-gamma (IFN)] , IL-2 , IL-4 , and IL-10 in cardiac allografts to elucidate its immunological mechanism . Negative_regulation IFNGR2 TNF 16771709 1599262 Using the yeast-transactivator-GAL4 system , we showed that both [AF-1] and AF-2 ( activation functions 1 and 2 ) of HNF-4 are *inhibited* by and that this inhibition was abolished by overexpression of different HNF-4 co-activators , including PGC-1 ( peroxisome-proliferator-activated-receptor-gamma co-activator 1 ) , CBP [ CREB ( cAMP-response-element binding protein ) binding protein ] and SRC3 ( steroid receptor co-activator 3 ) . Negative_regulation IGF1 ALDH2 20731752 2452694 Our data further depicted a likely *role* of Caspase-3 , and AMPK activation in [IGF-1] deficiency induced ` desensitization ' of alcoholic cardiomyopathy . Negative_regulation IGF1 CTGF 23555635 2767367 Our data indicates that the observed effects of may be *mediated* in part by CCN2 induced overexpression of [IGF-I] and IGF-II . Negative_regulation IGF1 EPHB2 17644731 1798832 This study was undertaken to elucidate the mechanisms underlying anti-beta2M mAb induced PI3K/Akt and *inhibition* and the inability of IL-6 and [IGF-I] to protect myeloma cells from mAb induced apoptosis . Negative_regulation IGF1 EPHB2 19762915 2158847 Chemical inhibition of significantly *enhanced* [IGF-I] phosphorylation of Akt and alleviated tBHP inhibition of Akt phosphorylation . Negative_regulation IGF1 FOXO1 23152492 2729643 In vivo , combined loss of and FoxO3 specifically in cardiomyocytes *leads* to delayed cell-cycle withdrawal and increased expression of [IGF1] and FoxM1 . Negative_regulation IGF1 IFI27 15799773 1390568 Several genes , including [insulin-like growth factor 1 (IGF-1)] and cyclin dependent kinase *inhibitor* ( ( Kip1 ) ) were induced by both injury types and these may have potential clinical application as markers of tissue damage . Negative_regulation IGF1 IGFBP1 10828490 697217 On the basis of such an experiment , performed at equilibrium , should *reduce* the mitogenic activity of [IGF-1] . Negative_regulation IGF1 IGFBP1 11006202 735202 Thus , it is suggested that *induced* inhibition of [IGF] activity is unlikely to be responsible for the impaired trophoblast invasion observed in pre-eclampsia . Negative_regulation IGF1 IGFBP1 1721071 171720 *inhibition* of [IGF] binding occurred similarly under both 4 degrees and 37 degrees C conditions . Negative_regulation IGF1 IGFBP1 1721920 173243 It is concluded that : ( i ) after a refractory period , granulosa cells from hyperstimulated follicles retained their mitogenic activity ; ( ii ) IGF-I is capable of stimulating DNA amplification in granulosa cells ; and ( iii ) *inhibits* the [IGF-I] stimulated proliferation in these cells . Negative_regulation IGF1 IGFBP1 17699799 1782853 is a downstream target of insulin and *inhibits* [IGF-I] activity . Negative_regulation IGF1 IGFBP1 19707314 1841246 Dexamethasone impairs IGF and IGFBP secretion and stimulates , an *inhibitor* of [IGF-I] . Negative_regulation IGF1 IGFBP1 2175183 145722 In monolayer cultures of fetal skin fibroblasts both forms of *inhibited* binding of [ 125I ] [IGF-I] onto the cells , but amplified the IGF-I stimulated [ 3H ] thymidine incorporation into the same cells . Negative_regulation IGF1 IGFBP1 23354097 2743145 nonetheless most dramatic inhibitory effects on the biological activity of [IGF-I] were *due* to phosphorylation at S119 . Negative_regulation IGF1 IGFBP1 2461387 100184 Purified 34K as well as decidual cytosols *inhibited* [ 125I ] [IGF-I] binding to placental receptors . Negative_regulation IGF1 IGFBP1 24790301 1358920 These observations suggest that increase in serum free [IGF-I] levels during puberty is *caused* by a dramatic increase in total IGF-I , rather than IGFBP-3 , and a decrease in . Negative_regulation IGF1 IGFBP1 2707157 111105 Inhibition of IGF-I stimulated thymidine incorporation paralleled the ability of to *inhibit* [IGF-I] binding to the surface of FRTL5 . Negative_regulation IGF1 IGFBP1 7514606 254091 In tissue culture experiments with sensory- and motoneurons we demonstrate that the neurite promoting activity of [IGF1] is *blocked* by , and that a similar IGF-BP-sensitive activity is detected in muscle extracts from paralyzed , but not from control muscle . Negative_regulation IGF1 IGFBP1 7522203 269567 Similarly , *inhibited* [125I-IGF-I] binding to granulosa cells . Negative_regulation IGF1 IGFBP1 7522266 269628 In contrast , *inhibits* both [125I-IGF-I] binding to placental membrane and 3H-glycine uptake of trophoblast cells by IGF-I in a dose dependent manner . Negative_regulation IGF1 IGFBP1 7683523 216486 Furthermore MAb A was found to abolish *inhibition* of [IGF] stimulation in an in vitro proliferation assay . Negative_regulation IGF1 IGFBP1 7690486 228613 However , several studies demonstrate that *inhibits* [IGF] binding to cell surface receptors and thereby inhibits IGF mediated mitogenic and cell metabolic actions . Negative_regulation IGF1 IGFBP1 7693845 234237 These results show that the reduction in during pregnancy dramatically *increased* the clearance of [IGF-I] from the circulation towards that obtained with LR3IGF-I . Negative_regulation IGF1 IGFBP1 8626847 361061 We speculate that low serum [IGF-I] and IGFBP-3 levels would be partially *due* to the increased urinary losses of serum complexes , especially that of 150 kDa , and these changes may contribute to growth failure in persistent nephrotic syndrome . Negative_regulation IGF1 IGFBP1 9135573 427815 and IGFBP-3 , but not an N-terminal fragment of IGFBP-3 , could effectively *block* binding of both [IGF-I] and IGF-II to the solid-phase IGFBP-3 . Negative_regulation IGF1 IGFBP1 9626122 511761 It is possible that insulin mediated suppression of in obese children may *increase* free [IGF-I] levels and thus contribute to somatic growth . Negative_regulation IGF1 IL1B 1537287 180513 also *suppressed* [IGF-I] mRNA expression in Leydig cells in vitro in a time- and dose dependent fashion . Negative_regulation IGF1 IL1B 1537287 180514 ( 100 ng/ml ) *inhibited* [IGF-I] mRNA expression to about 10 % of the controls ( P less than 0.01 ) . Negative_regulation IGF1 IL1B 17697350 1794462 Progrado prevented *induced* suppression of [IGF-1] production from human cartilage explants as well as stimulating basal IGF-1 production ( P < 0.05 ) . Negative_regulation IGF1 IL1B 7510466 249923 also *increased* the number of [IGF-I] receptors but had no effect on receptor affinity . Negative_regulation IGF1 IL1B 7544275 318246 In conclusion , *inhibits* [IGF-I] but increases IGFBP-3 expression in Leydig cells , and this may contribute to the inhibitory effects of IL-1 beta on Leydig cell steroidogenesis . Negative_regulation IGF1 IL1B 8780229 380075 Whereas the enhanced endogenous production of glucocorticoids appears to mediate the *induced* decrease in [IGF-I] synthesis in liver , the changes in IGF-I content observed in other tissues and the increase in IGFBP-1 and IGFBP-2 appear to be largely glucocorticoid independent . Negative_regulation IGF1 IL1B 9025720 405834 In conclusion , we demonstrated that in rat hepatocytes in primary culture and TNF-alpha *inhibited* GH-stimulated [IGF-I] synthesis . Negative_regulation IGF1 TNF 10404006 629136 CGRP inhibits osteoclasts , stimulates [insulin-like growth factor I] and *inhibits* alpha production by osteoblasts in vitro . Negative_regulation IGF1 TNF 11089525 751216 Northern analysis revealed that *inhibited* the expression of [insulin-like growth factor I (IGF-I)] . Negative_regulation IGF1 TNF 12388149 1012726 Taken together , our data suggest that induced in muscle after LPS injection can locally *inhibit* [IGF-I] expression . Negative_regulation IGF1 TNF 12697682 1081351 The purpose of the present study was to determine whether LPS alters the expression of TNF alpha and IGF-I in mouse skeletal muscle and whether directly *inhibits* [IGF-I] mRNA expression in C2C12 myoblasts . Negative_regulation IGF1 TNF 12697682 1081352 completely *prevented* GH-inducible [IGF-I] mRNA expression , but this GH resistance was not attributable to impairment in signal transducer and activator of transcription-3 or -5 phosphorylation . Negative_regulation IGF1 TNF 16574984 1568538 *attenuated* JAK2/STAT5 and ERK1/2 phosphorylation and [IGF-I] and Spi 2.1 mRNA expression following GH stimulation . Negative_regulation IGF1 TNF 18719026 1984922 *inhibits* serine protease inhibitor 2.1 ( Spi 2.1 ) and [IGF-I] gene expression by GH in CWSV-1 hepatocytes . Negative_regulation IGF1 TNF 18719026 1984925 The 5- to 6-fold induction of Spi 2.1 and [IGF-I] promoter activity by GH was *inhibited* by . Negative_regulation IGF1 TNF 20009360 2232258 *inhibits* [insulin-like growth factor-I (IGF-I)] activities in human trophoblast cell cultures through IGF-I/insulin hybrid receptors . Negative_regulation IGF1 TNF 23079385 2695008 *reduced* [IGF-I] and IGF-II protein levels to 51±8 % and 69±8 % , respectively ( P=0.002 ) , without affecting mRNA levels . Negative_regulation IGF1 TNF 8218594 231762 [Insulin-like growth factor-1] activity is *inhibited* by interleukin-1 alpha , , and interleukin-6 . Negative_regulation IGF1 TNF 9025720 405833 In conclusion , we demonstrated that in rat hepatocytes in primary culture IL-1 beta and *inhibited* GH-stimulated [IGF-I] synthesis . Negative_regulation IGF1 TNF 9048612 416821 IL-1 beta , and to a lesser extent , dramatically *inhibited* the [IGF-I] mRNA response to GH ( IL-1 beta : -82 % , P < 0.001 and TNF-alpha : -47 % , P < 0.01 ) . Negative_regulation IGF1 TNF 9276092 450684 We recently reported that CGRP stimulates the production of the growth factor [insulin-like growth factor-I] and *inhibits* that of the cytokine by osteoblasts , suggesting that CGRP may control bone cell activity . Negative_regulation IGF1 TNF 9397943 291195 Recombinant murine *inhibits* cholesterol side-chain cleavage cytochrome P450 and [insulin-like growth factor-I] gene expression in rat Leydig cells . Negative_regulation IGF1 TNF 9500575 490835 However , in the jejunum and ileum , refeeding had no effect but *caused* a decrease in [IGF-I] and IGFBP-3 mRNA levels in malnourished rats . Negative_regulation IGF1R CTGF 18586434 1935267 Despite being an IGF binding protein , CTGF did not affect IGF1 induced phosphorylation of IGF1 receptor (IGF1R) or IGF1R expression in MAC-T cells , indicating that the attenuating effect of on IGF1 stimulated proliferation of MAC-T cells was not *mediated* by decreasing IGF1 's ability to bind to IGF1R or by decreasing [IGF1R] expression . Negative_regulation IGF1R IGFBP1 1710998 158296 [IGF-I receptor] binding to HEC 1B and KLE cells was inhibited in the *presence* of purified . Negative_regulation IGF1R TNFSF10 24535016 2919010 In particular , significantly *inhibited* [insulin-like growth factor-1 receptor] ( IGF-1R ) and NF?B . Negative_regulation IGF2 CTGF 23555635 2767368 Our data indicates that the observed effects of CCN2 may be mediated in part by *induced* overexpression of IGF-I and [IGF-II] . Negative_regulation IGF2 IGFBP1 11006202 735203 Thus , it is suggested that induced *inhibition* of [IGF] activity is unlikely to be responsible for the impaired trophoblast invasion observed in pre-eclampsia . Negative_regulation IGF2 IGFBP1 1696279 137237 *inhibited* basal and [IGF II-stimulated] bone cell DNA synthesis . Negative_regulation IGF2 IGFBP1 1721071 171721 *inhibition* of [IGF] binding occurred similarly under both 4 degrees and 37 degrees C conditions . Negative_regulation IGF2 IGFBP1 7683523 216487 Furthermore MAb A was found to abolish *inhibition* of [IGF] stimulation in an in vitro proliferation assay . Negative_regulation IGF2 IGFBP1 7690486 228614 However , several studies demonstrate that *inhibits* [IGF] binding to cell surface receptors and thereby inhibits IGF mediated mitogenic and cell metabolic actions . Negative_regulation IGF2 IGFBP1 9135573 427817 and IGFBP-3 , but not an N-terminal fragment of IGFBP-3 , could effectively *block* binding of both IGF-I and [IGF-II] to the solid-phase IGFBP-3 . Negative_regulation IGF2 TNF 10797307 689841 All treatments suppressed [IGF-II] production but only *blocked* IGFBP-5 secretion . Negative_regulation IGF2 TNF 23079385 2695009 *reduced* IGF-I and [IGF-II] protein levels to 51±8 % and 69±8 % , respectively ( P=0.002 ) , without affecting mRNA levels . Negative_regulation IGF2 TNF 8386114 215063 and interferon-gamma *inhibit* [insulin-like growth factor II] gene expression in human fetal adrenal cell cultures . Negative_regulation IGFALS IL1B 10660535 664474 *reduced* the ability of GH to stimulate ALS mRNA in rat primary hepatocytes and [ALS] promoter activity in H4-II-E rat hepatoma cells . Negative_regulation IGFBP1 AKT1 11672436 872459 Importantly , the activation of and phosphorylation of FKHR is not , in itself , *sufficient* to reduce [IGFBP-1] gene expression in the presence of phorbol esters . Negative_regulation IGFBP1 AKT1 22072736 2534177 Moreover , inhibition of with MK2206 , an allosteric AKT inhibitor , dramatically *increased* the accumulation of nuclear FOXO1 as well as expression of [IGFBP1] . Negative_regulation IGFBP1 AKT2 22072736 2534178 Moreover , inhibition of with MK2206 , an allosteric AKT inhibitor , dramatically *increased* the accumulation of nuclear FOXO1 as well as expression of [IGFBP1] . Negative_regulation IGFBP1 AKT3 22072736 2534179 Moreover , inhibition of with MK2206 , an allosteric AKT inhibitor , dramatically *increased* the accumulation of nuclear FOXO1 as well as expression of [IGFBP1] . Negative_regulation IGFBP1 CGA 1722684 173728 The constitutive secretion of [IGFBP] was *inhibited* by ( TSH , 0.3 mU per mL ) . Negative_regulation IGFBP1 DNMT3B 23233487 2769122 Although forced expression of DNMT3B by itself is insufficient to inhibit decidualization , forced expression of in combination with MPA-mix synergistically up-regulated PRB , as well as *attenuated* the expression of [IGFBP1] , the decidualization marker . Negative_regulation IGFBP1 FOXO1 10702299 672609 The forkhead rhabdomyosarcoma transcription factor ( ) is a promising candidate to be the transcription factor that binds to the insulin response element of the insulin-like growth factor binding protein-1 ( IGFBP-1 ) promoter and *mediates* insulin inhibition of [IGFBP-1] promoter activity . Negative_regulation IGFBP1 FOXO1 11672436 872458 Importantly , the activation of PKB and phosphorylation of is not , in itself , *sufficient* to reduce [IGFBP-1] gene expression in the presence of phorbol esters . Negative_regulation IGFBP1 FOXO1 22072736 2534172 Overexpression of triple-mutant *increased* mRNA levels of [IGFBP1] and PRL in OsisSC in the presence of M+A , whereas the overexpression of wild-type FOXO1 had no effect . Negative_regulation IGFBP1 GCG 1706258 153002 To study the *role* of GH and in the regulation of IGF-I and [IGF-BP] production , we examined IGF-I and IGF-BPs secreted by primary rat hepatocytes cultured in a serum-free medium . Negative_regulation IGFBP1 GH1 1379198 192796 This *dependent* regulation of IGF-I and [IGFBP-1] production by adult rat hepatocytes in culture indicates an important autocrine/paracrine role for IGF-I , particularly during liver regeneration after extensive organ mass loss . Negative_regulation IGFBP1 HIF1A 16428465 1516029 Hypoxia increased the HIF-1 activity , and overexpression or CoCl2 treatment *resulted* in elevated [IGFBP-1] expression in zebra fish embryos . Negative_regulation IGFBP1 HOXA10 17350963 1727204 The functional *role* of in [IGFBP1] expression was further explored using human endometrial stromal cells (HSC) . Negative_regulation IGFBP1 HOXA5 12163409 972365 In HepG2 cells , has little effect by itself but *inhibits* the FKHR dependent activation of the [IGFBP1] promoter . Negative_regulation IGFBP1 IGF1 10859237 704821 In conclusion , secretion of [IGFBP-1] is increased during luteolysis , and may *inhibit* the steroidogenic effects of , but no evidence was found to implicate IGFBP-1 in the embryotoxic effect of regressing CL . Negative_regulation IGFBP1 IGF1 11397868 823847 [IGFBP-1] is primarily made in the liver , and it mostly *inhibits* actions at the cellular level . Negative_regulation IGFBP1 IGF1 1281161 205604 The fasting induced increase in [IGFBP-30K] is *inhibited* by IGF-I and by and , to a lesser extent , by insulin . Negative_regulation IGFBP1 IGF1 12933666 1132614 Complementary studies demonstrated that [IGFBP-1] also decreased the rates of protein synthesis under basal conditions and in *response* to stimulation by when added in vitro to the fast-twitch epitrochlearis muscle . Negative_regulation IGFBP1 IGF1 1381377 196067 Inhibition of [IGFBP-1] production in *response* to was dose dependent , with the highest effect observed at 5 nM IGF-I . Negative_regulation IGFBP1 IGF1 14568572 1155344 and IGF-II also *inhibited* the [IGFBP-1] and SHBG levels . Negative_regulation IGFBP1 IGF1 1697605 139588 *inhibited* release of both [IGF-BP-1] and the 24,000 Mr form . Negative_regulation IGFBP1 IGF1 1697605 139589 Both and insulin also *blocked* the relaxin mediated increase in [IGF-BP-1] . Negative_regulation IGFBP1 IGF1 17365107 1713356 The secretion of significantly increased compared to control , but [IGFBP-1] secretion was *inhibited* . Negative_regulation IGFBP1 IGF1 18583428 1946744 MPA and E ( 2 ) induced decidualization of stromal cells , while *inhibited* decidualization by MPA and E ( 2 ) as well as PRL and [IGFBP-1] secretion into medium . Negative_regulation IGFBP1 IGF1 7505466 237660 Both and IGF-II in concentrations as low as 1-10 nmol/l *caused* significant suppression of [IGFBP-I] protein levels . Negative_regulation IGFBP1 IGF1 7505466 237664 Our data indicate that [IGFBP-1] production is *inhibited* by its ligands , and IGF-II , and that this effect is probably mediated at the transcriptional level . Negative_regulation IGFBP1 IGF1 7522203 269568 Immunoreactive [IGFBP-1] released into the medium was *inhibited* by both and follicle stimulating hormone dose-dependently with an IC50 of 0.14 and 0.13 nM , respectively , while human chorionic gonadotropin stimulated IGFBP-1 release with a 50 % effective dose ( ED50 ) of 0.6 nM . Negative_regulation IGFBP1 IGF1 7522266 269629 Similarly IGFBP-1 , -2 , and -4 are detected in medium conditioned by term decidua cells by Western ligand blot in which release of [IGFBP-1] and -4 are *diminished* by and all three IGFBPs are increased by progesterone . Negative_regulation IGFBP1 IGF1 7684393 217569 *inhibits* production of [IGF binding protein-1] while stimulating estradiol secretion in granulosa cells from normal and polycystic human ovaries . Negative_regulation IGFBP1 IGF1 8636256 362246 We conclude that 1 ) both insulin and *inhibit* [IGFBP-1] production by cultured human granulosa cells ; Negative_regulation IGFBP1 IGF1 9654167 516105 alone *resulted* in a significant dose dependent increase in medium estradiol ( E2 ) ( p < 0.05 ) and progesterone ( P ) ( p < 0.001 ) and suppression of [IGF binding protein-1 (IGFBP-1)] ( p < 0.001 ) , without any increase in [ 3H ] -thymidine incorporation ( P=0.10 ) . Negative_regulation IGFBP1 IGF2 11397868 823848 [IGFBP-1] is primarily made in the liver , and it mostly *inhibits* actions at the cellular level . Negative_regulation IGFBP1 IGF2 14568572 1155345 IGF-I and also *inhibited* the [IGFBP-1] and SHBG levels . Negative_regulation IGFBP1 IGF2 7505466 237661 Both IGF-I and in concentrations as low as 1-10 nmol/l *caused* significant suppression of [IGFBP-I] protein levels . Negative_regulation IGFBP1 IGF2 7505466 237665 Our data indicate that [IGFBP-1] production is *inhibited* by its ligands , IGF-I and , and that this effect is probably mediated at the transcriptional level . Negative_regulation IGFBP1 IGF2 8784106 380514 We conclude that *inhibits* [IGFBP-I] production in luteinized human granulosa cells in a dose dependent manner and with potency similar to IGF-I and higher than insulin . Negative_regulation IGFBP1 IGFBP2 18234122 1871291 In the absence of insulin , synthesis of [IGFBP-1] was *induced* in explants with low levels of de novo synthesis whereas synthesis was inhibited . Negative_regulation IGFBP1 IGFBP7 17884839 1802400 Knocking down the endogenous expression in stromal cells , by a small interfering ( si ) RNA , *diminished* the expression of prolactin and [IGFBP-1] which serve as decidual markers . Negative_regulation IGFBP1 INS 10626552 576258 During the clamp studies , the adolescents exhibited low levels of IGFBP-1 and -2 as well as a reduced *induced* suppression of [IGFBP-1] , compared with lean adults . Negative_regulation IGFBP1 INS 10702299 672610 The forkhead rhabdomyosarcoma transcription factor ( FKHR ) is a promising candidate to be the transcription factor that binds to the insulin response element of the insulin-like growth factor binding protein-1 ( IGFBP-1 ) promoter and mediates *inhibition* of [IGFBP-1] promoter activity . Negative_regulation IGFBP1 INS 10990441 478729 Cytotrophoblasts showed limited invasion into endometrial stromal multilayers decidualized in vitro secreting abundant IGFBP-1 , but invaded multilayers when [IGFBP-1] production was *inhibited* by . Negative_regulation IGFBP1 INS 11302732 803427 ( 100 ng/ml ) *inhibited* [IGFBP-1] by 80 % ( P < 0.001 ) , but this was completely abolished in the presence of 150 microM AICAR . Negative_regulation IGFBP1 INS 11443175 833824 [IGFBP-1] production in tissue culture medium from human granulosa cells was *inhibited* by to the nadir of 45 % of control ( P < 0.0001 ) . Negative_regulation IGFBP1 INS 11445561 850483 Forkhead ( FKHR ) recognizes IRS sequences , is phosphorylated in response to insulin , and mediates *inhibition* of basal [IGFBP-1] transcription in an IRS dependent manner . Negative_regulation IGFBP1 INS 11445561 850486 Expression of T/S/S , in which three putative protein kinase B (PKB) sites in FKHR are mutated , reduced *inhibition* of basal expression of [IGFBP-1] but not PEPCK . Negative_regulation IGFBP1 INS 11445561 850487 Mutations in the IRS or FKHR had no effect on *inhibition* of glucocorticoid induced transcription of either the PEPCK or [IGFBP-1] gene . Negative_regulation IGFBP1 INS 11551849 857041 These data suggest that increased IGFBP-3-PA during insulin infusion after surgery governs the increased levels of fIGF-I , while *induced* suppression of [IGFBP-1] was not affected by surgery . Negative_regulation IGFBP1 INS 11834727 929122 The synthesis of [IGFBP-1] is *suppressed* by , and administration of IGFBP-1 to rats results in impaired glucose metabolism . Negative_regulation IGFBP1 INS 11942857 953535 Hepatic expression of insulin-like growth factor binding protein-1 ( [IGFBP-1] ) is rapidly and completely *inhibited* by . Negative_regulation IGFBP1 INS 11942857 953539 Our results support the view that the *mediated* repression of [IGFBP-1] gene expression is partly mTOR dependent , and demonstrate that H ( 2 ) O ( 2 ) selectively antagonizes mTOR dependent insulin action . Negative_regulation IGFBP1 INS 12095507 960750 ( 100 microU/mL-800 microU/mL ) , LH ( 1 microg/L-10 microg/L ) , and A ( 10 ( -5 ) mol/L ) *caused* a significant decrease in [IGFBP-1] accumulation in the medium both alone and when added in combination . Negative_regulation IGFBP1 INS 12096082 960847 *inhibits* the production of [IGFBP-1] and perhaps IGFBP-2 . Negative_regulation IGFBP1 INS 12096082 960848 As a result , chronically elevated fasting and postprandial levels may *lead* to a decrease in circulating [IGFBP-1] and IGFBP-2 concentrations and , consequently , an increase in IGF-I bioavailability . Negative_regulation IGFBP1 INS 12466347 1022345 In the liver , [IGFBP-1] is transcriptionally *repressed* by , and it is therefore a potential marker of hepatic insulin sensitivity . Negative_regulation IGFBP1 INS 12659874 1074093 [IGFBP-1] is *inhibited* transcriptionally by and is also regulated by a number of pathways that influence hepatic insulin sensitivity . Negative_regulation IGFBP1 INS 12775252 1095363 can *suppress* basal ( without hormone ) and P-stimulated [IGFBP-I] secretions in cultured stromal cells from human secretory endometrium in a dose dependent manner . Negative_regulation IGFBP1 INS 1281161 205611 Unlike cell associated IGFBP-30K , secretion of IGFBP was stimulated ( 6.8 +/- 0.5-fold , n = 2 ) by IGF-I , whereas [IGFBP] secretion was *inhibited* 54 % by . Negative_regulation IGFBP1 INS 1281485 205709 As [IGFBP-1] is *inhibited* by and GH , the dynamic pattern of alterations in GH and insulin levels was also assessed . Negative_regulation IGFBP1 INS 12914928 1129823 rapidly and completely *inhibits* expression of the hepatic insulin-like growth factor binding protein-1 ( [IGFBP-1] ) , phosphoenolpyruvate carboxykinase ( PEPCK ) and glucose-6-phosphatase (G6Pase) genes . Negative_regulation IGFBP1 INS 1370614 179470 In combination with , a potent *inhibitor* of [IGFBP-1] gene transcription , this early effect of phorbol esters is dominant . Negative_regulation IGFBP1 INS 1379255 192989 [IGFBP-1] production is potently *inhibited* by both in vivo and in HepG2 human hepatoma cells . Negative_regulation IGFBP1 INS 14624764 1170042 In normal physiology , [IGFBP-1] transcription is potently *inhibited* by and serum levels are limited by a rapid clearance rate . Negative_regulation IGFBP1 INS 15613433 1375434 [IGFBP-1] secretion is primarily stimulated by progesterone and cAMP and is *inhibited* by and IGFs . Negative_regulation IGFBP1 INS 16131582 1474768 Pioglitazone and rosiglitazone enhanced *induced* inhibition of [IGFBP-1] production by 13 % and 20 % , respectively ( P < 0.001 ) . Negative_regulation IGFBP1 INS 16131582 1474769 PPAR-gamma agonists directly stimulate progesterone and IGFBP-1 production , inhibit estradiol and testosterone production , abolish insulin induced stimulation of testosterone production and insulin dependent stimulation of estradiol production in the presence of FSH , and enhance *induced* inhibition of [IGFBP-1] production in human ovarian cells . Negative_regulation IGFBP1 INS 16455781 1547955 The expression of [IGF binding protein-1 (IGFBP-1)] is induced in rat liver by dexamethasone and glucagon and is completely *inhibited* by 100 nM . Negative_regulation IGFBP1 INS 16455781 1547959 In subconfluent hepatocytes , *inhibition* of [IGFBP-1] mRNA levels was blocked by inhibiting PI3 kinase activation , and there was a corresponding inhibition of Foxo1/Foxo3 phosphorylation . Negative_regulation IGFBP1 INS 16455781 1547964 In confluent hepatocytes , could not activate the phosphatidylinositol 3-kinase ( PI3 kinase ) -Akt-Foxo1/Foxo3 pathway , but still *inhibited* [IGFBP-1] gene expression in an mTOR dependent manner . Negative_regulation IGFBP1 INS 16455781 1547966 In contrast , 1 nm *inhibited* the [IGFBP-1] mRNA level by 40 % and correspondingly activated Akt and Foxo1/Foxo3 phosphorylation to a level comparable to that observed with 100 nM insulin . Negative_regulation IGFBP1 INS 16455781 1547972 In conclusion , we have found that in rat liver , *inhibition* of [IGFBP-1] mRNA levels can occur in the absence of the phosphorylation of Foxo1/Foxo3 , whereas activation of the mTOR pathway is both necessary and sufficient . Negative_regulation IGFBP1 INS 1697605 139590 Both IGF-I and also *blocked* the relaxin mediated increase in [IGF-BP-1] . Negative_regulation IGFBP1 INS 1703482 151376 From these observations we conclude the enhanced expression of [IGFBP-1] in the food deprived rat may be a *consequence* of GH deficiency rather than deficiency . Negative_regulation IGFBP1 INS 17088407 1644081 This study suggests that the major inhibitory *role* of in the regulation of liver [IGFBP-1] production in mammals is not found in salmon . Negative_regulation IGFBP1 INS 1715344 164980 In contrast , *inhibited* the secretion of [IGFBP-1] but increased the secretion of the 24,000 Mr form . Negative_regulation IGFBP1 INS 1719386 169623 *inhibited* [IGFBP-1] in the medium by 80 % in the absence of glucose , suggesting that the inhibition is a direct effect of insulin ; Negative_regulation IGFBP1 INS 18234122 1871288 clearly *inhibited* [IGFBP-1] production and mRNA expression in a time- and dose dependent manner , whereas IGFBP-2 synthesis was not significantly affected . Negative_regulation IGFBP1 INS 20216949 2223458 These results indicate that PQ-induced oxidative stress impairs insulin dependent mTOR activation and that this impairment probably causes inhibition of *dependent* repression of [IGFBP-1] expression . Negative_regulation IGFBP1 INS 20711952 2312892 1,25- ( OH ) 2D3 alone stimulated IGFBP-1 production by 24 % ( p < 0.001 ) , however , in the *presence* of , 1,25- ( OH ) 2D3 enhanced insulin induced inhibition of [IGFBP-1] production by 13 % ( p < 0.009 ) . Negative_regulation IGFBP1 INS 21051252 2349351 *caused* a similar decrease ( p < 0.05 all groups ) in [IGFBP-1] mean levels for the first 90 min in the T2D patients with CKD5D ( 73±7 % of basal IGFBP-1 values ) and the T1D patients ( 69±6 % ) with normal renal function . Negative_regulation IGFBP1 INS 22187946 2531293 Our data suggest that the degradation of IRS-1 by HCV core protein translates to impaired ability of to *inhibit* the expression of the target gene [IGFBP-1] in the liver and may serve as a novel mechanism for insulin resistance and hyperglycaemia . Negative_regulation IGFBP1 INS 22189999 2558600 Interestingly , exogenous failed to suppress total adiponectin in Arg1174Gln carriers , but *reduced* [IGFBP1] and increased IGFBP2 as in controls . Negative_regulation IGFBP1 INS 22843786 2677000 prevented RTEF-1 expression and significantly *inhibited* [IGFBP-1] transcription in endothelial cells in a dose dependent fashion . Negative_regulation IGFBP1 INS 2481706 122724 *suppressed* [IGFBP-1] secretion maximally at 100 mU/l ( -32 % ) within 6 h . Negative_regulation IGFBP1 INS 2542098 112186 The authors evaluated the *role* of in the regulation of serum levels of 34K [IGF-BP] in patients with polycystic ovarian disease ( PCOD ) . Negative_regulation IGFBP1 INS 2707157 111106 did not *inhibit* the binding of 125I labeled IGFs to [PP12] , and PP12 did not inhibit the ability of insulin to stimulate DNA synthesis . Negative_regulation IGFBP1 INS 7476310 331566 *reduces* hepatic production of [IGF binding protein-1 (IGFBP-1)] , an in vitro inhibitor of IGF bioactivity , and it has been suggested that the obesity related hyperinsulinemia may increase free ( bioactive ) IGF in vivo by reducing the concentration of IGFBP-1 . Negative_regulation IGFBP1 INS 7505463 237650 *caused* a dose dependent reduction of [IGFBP-1] secretion ( half-maximal inhibition at < 1 ng/ml ) to a maximum of 1 % of control values . Negative_regulation IGFBP1 INS 7521340 243691 To determine the effect of aging on *induced* suppression of [IGFBP-1] , an oral glucose tolerance test ( OGTT ) was performed in 10 older ( 72-92 yr ) and 10 younger ( 24-58 yr ) nonobese subjects , matched for sex and body mass index . Negative_regulation IGFBP1 INS 7525123 276875 Octreotide treatment , in addition to reducing GH , IGF-I and insulin levels , is associated with an increase in IGFBP-1 concentrations in patients with acromegaly , and it is suggested that the rise in serum [IGFBP-1] is a *consequence* of the decrease in secretion . Negative_regulation IGFBP1 INS 7683312 216421 The release of [IGFBP-1] by hepatocytes was *inhibited* by ( 10 nM-1 microM ) , as was mRNA abundance . Negative_regulation IGFBP1 INS 7688368 225354 Similar results were observed with a second protein synthesis inhibitor , anisomycin , which also prevented the insulin induced decrease in IGFBP-1 mRNA without abolishing the *induced* inhibition of [IGFBP-1] transcription . Negative_regulation IGFBP1 INS 7694841 234376 We asked whether increased [IGFBP-1] expression in STZ-diabetic animals is *due* to an effect of deficiency per se or whether insulin deficiency represents a permissive state where glucocorticoids may play an important role in the regulation of IGFBP-1 and other circulating peptides involved in the modulation of IGF bioactivity . Negative_regulation IGFBP1 INS 8557761 347655 *inhibited* [IGFBP-1] up to 80 % , and this effect diminished with time in culture but was unaffected by cell density . Negative_regulation IGFBP1 INS 8636256 362247 We conclude that 1 ) both and IGF-I *inhibit* [IGFBP-1] production by cultured human granulosa cells ; Negative_regulation IGFBP1 INS 8754754 374398 ( 1-100 nM ) potently *inhibited* both basal and glucocorticoid stimulated [IGFBP-1] expression in hOB cells . Negative_regulation IGFBP1 INS 8754754 374399 A monoclonal antibody to the insulin receptor blocked insulin binding to insulin receptors and completely prevented *induced* suppression of [IGFBP-1] . Negative_regulation IGFBP1 INS 8817651 344467 This cis element appears crucial to the multihormonal regulation of hIGFBP-1 expression in liver , since ( i ) an intact IRE is required for maximal stimulation of hIGFBP-1 promoter activity by dexamethasone , and ( ii ) the IRE confers *inhibition* of both basal and dexamethasone stimulated [hIGFBP-1] promoter activity . Negative_regulation IGFBP1 INS 8817653 344470 Glucocorticoids stimulate and *inhibits* hepatic production of [IGFBP-1] at the level of gene transcription . Negative_regulation IGFBP1 INS 8854134 388042 Portal levels of are *critical* for the integrity of the hepatic GH receptor and suppression of the inhibitory [IGF binding protein I] . Negative_regulation IGFBP1 INS 8995239 409361 *suppressed* Dex/Gluc stimulated [IGFBP-1] but not IGFBP-4 mRNA levels . Negative_regulation IGFBP1 INS 9170816 433198 This increase in [IGFBP-1] by glucose in vitro , as opposed to the decrease of IGFBP-1 in vivo , may be *due* to a lack of circulatory maternal in the isolated placental preparation . Negative_regulation IGFBP1 INS 9626122 511763 It is possible that *mediated* suppression of [IGFBP-I] in obese children may increase free IGF-I levels and thus contribute to somatic growth . Negative_regulation IGFBP1 LEFTY1 20056823 2211948 Overexpression of LEFTY in decidualized HuF cells with an adenovirus that transduced *caused* a marked decrease in [IGFBP1] secretion , and withdrawal of medroxyprogesterone acetate from decidualized cells resulted in a decrease in IGFBP1 secretion and an increase in LEFTY expression . Negative_regulation IGFBP1 LEFTY2 20056823 2211947 Overexpression of in decidualized HuF cells with an adenovirus that transduced LEFTY caused a marked decrease in IGFBP1 secretion , and withdrawal of medroxyprogesterone acetate from decidualized cells *resulted* in a decrease in [IGFBP1] secretion and an increase in LEFTY expression . Negative_regulation IGFBP1 LRP5 18583428 1946745 MPA and E ( 2 ) induced decidualization of stromal cells , while *inhibited* decidualization by MPA and E ( 2 ) as well as PRL and [IGFBP-1] secretion into medium . Negative_regulation IGFBP1 MAPK1 19589865 2137057 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of CCND1 , but not cAMP up-regulation of [IGFBP1] , in hESF of women with vs. without endometriosis . Negative_regulation IGFBP1 MAPK10 19589865 2137058 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of CCND1 , but not cAMP up-regulation of [IGFBP1] , in hESF of women with vs. without endometriosis . Negative_regulation IGFBP1 MAPK11 19589865 2137059 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of CCND1 , but not cAMP up-regulation of [IGFBP1] , in hESF of women with vs. without endometriosis . Negative_regulation IGFBP1 MAPK12 19589865 2137060 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of CCND1 , but not cAMP up-regulation of [IGFBP1] , in hESF of women with vs. without endometriosis . Negative_regulation IGFBP1 MAPK13 19589865 2137061 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of CCND1 , but not cAMP up-regulation of [IGFBP1] , in hESF of women with vs. without endometriosis . Negative_regulation IGFBP1 MAPK14 19589865 2137062 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of CCND1 , but not cAMP up-regulation of [IGFBP1] , in hESF of women with vs. without endometriosis . Negative_regulation IGFBP1 MAPK15 19589865 2137056 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of CCND1 , but not cAMP up-regulation of [IGFBP1] , in hESF of women with vs. without endometriosis . Negative_regulation IGFBP1 MAPK3 19589865 2137063 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of CCND1 , but not cAMP up-regulation of [IGFBP1] , in hESF of women with vs. without endometriosis . Negative_regulation IGFBP1 MAPK3 24086495 2847871 Treatment with the ERK1/2 inhibitor , U0126 , significantly decreased the expression of the known decidualization marker genes , [IGFBP1] and PRL as well as *inhibited* the induction of known target genes ; Negative_regulation IGFBP1 MAPK4 19589865 2137064 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of CCND1 , but not cAMP up-regulation of [IGFBP1] , in hESF of women with vs. without endometriosis . Negative_regulation IGFBP1 MAPK6 19589865 2137065 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of CCND1 , but not cAMP up-regulation of [IGFBP1] , in hESF of women with vs. without endometriosis . Negative_regulation IGFBP1 MAPK7 19589865 2137066 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of CCND1 , but not cAMP up-regulation of [IGFBP1] , in hESF of women with vs. without endometriosis . Negative_regulation IGFBP1 MAPK8 19589865 2137067 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of CCND1 , but not cAMP up-regulation of [IGFBP1] , in hESF of women with vs. without endometriosis . Negative_regulation IGFBP1 MAPK9 19589865 2137068 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of CCND1 , but not cAMP up-regulation of [IGFBP1] , in hESF of women with vs. without endometriosis . Negative_regulation IGFBP1 MTOR 11784721 916785 We propose that these observations indicate that an dependent , but S6K independent mechanism *regulates* the suppression of [IGFBP-1] ( but not G6Pase ) gene expression by insulin . Negative_regulation IGFBP1 MTOR 11942857 953538 Our results support the view that the insulin mediated repression of [IGFBP-1] gene expression is partly *dependent* , and demonstrate that H ( 2 ) O ( 2 ) selectively antagonizes mTOR dependent insulin action . Negative_regulation IGFBP1 NFKB1 9575170 502600 This differential induction of iNOS as compared with similar *activation* of by inhibitors of [PP 1/2A] indicates the involvement of different intracellular signaling events for the induction of iNOS in two cell types of the same animal species . Negative_regulation IGFBP1 PGR 15987820 1452610 In the present study , we investigated the *role* of two transcription factors , and a member of the forkhead box class O family of transcription factors ( FOXO1A ) , in the regulation of the [IGFBP1] gene in endometrial cells . Negative_regulation IGFBP1 PGR 9178756 434238 *inhibits* expression of insulin-like growth factor binding protein-1 ( [IGFBP-1] ) in human endometrial cell line HEC-1B : characterization of the inhibitory effect of PR on the distal promoter region of the IGFBP-1 gene . Negative_regulation IGFBP1 PI3 16455781 1547960 In subconfluent hepatocytes , insulin inhibition of [IGFBP-1] mRNA levels was *blocked* by inhibiting kinase activation , and there was a corresponding inhibition of Foxo1/Foxo3 phosphorylation . Negative_regulation IGFBP1 PRKACB 10965886 728057 Conversely , a inhibitor ( H-89 ) *inhibited* the ability of cAMP , but not IL-1beta to stimulate [IGFBP-1] synthesis . Negative_regulation IGFBP1 PRKACB 11874707 918804 We have now investigated the responses to activation and *inhibition* of [PP1/2A] and used PTP inhibitors to examine the relationship between the morphological changes and enhanced steroid production . Negative_regulation IGFBP1 PRKACB 15604115 1380776 and Dex also synergistically induced a minimal 3 x glucocorticoid response element promoter , but *inhibited* Dex induction of the mouse mammary tumor virus and [IGF binding protein 1] promoters , even though PKA alone did not regulate these promoters . Negative_regulation IGFBP1 PRKACG 10965886 728058 Conversely , a inhibitor ( H-89 ) *inhibited* the ability of cAMP , but not IL-1beta to stimulate [IGFBP-1] synthesis . Negative_regulation IGFBP1 PRKACG 11874707 918805 We have now investigated the responses to activation and *inhibition* of [PP1/2A] and used PTP inhibitors to examine the relationship between the morphological changes and enhanced steroid production . Negative_regulation IGFBP1 PRKACG 15604115 1380777 and Dex also synergistically induced a minimal 3 x glucocorticoid response element promoter , but *inhibited* Dex induction of the mouse mammary tumor virus and [IGF binding protein 1] promoters , even though PKA alone did not regulate these promoters . Negative_regulation IGFBP1 PRKAR1A 10965886 728059 Conversely , a inhibitor ( H-89 ) *inhibited* the ability of cAMP , but not IL-1beta to stimulate [IGFBP-1] synthesis . Negative_regulation IGFBP1 PRKAR1A 11874707 918806 We have now investigated the responses to activation and *inhibition* of [PP1/2A] and used PTP inhibitors to examine the relationship between the morphological changes and enhanced steroid production . Negative_regulation IGFBP1 PRKAR1A 15604115 1380778 and Dex also synergistically induced a minimal 3 x glucocorticoid response element promoter , but *inhibited* Dex induction of the mouse mammary tumor virus and [IGF binding protein 1] promoters , even though PKA alone did not regulate these promoters . Negative_regulation IGFBP1 PRKAR1B 10965886 728060 Conversely , a inhibitor ( H-89 ) *inhibited* the ability of cAMP , but not IL-1beta to stimulate [IGFBP-1] synthesis . Negative_regulation IGFBP1 PRKAR1B 11874707 918807 We have now investigated the responses to activation and *inhibition* of [PP1/2A] and used PTP inhibitors to examine the relationship between the morphological changes and enhanced steroid production . Negative_regulation IGFBP1 PRKAR1B 15604115 1380779 and Dex also synergistically induced a minimal 3 x glucocorticoid response element promoter , but *inhibited* Dex induction of the mouse mammary tumor virus and [IGF binding protein 1] promoters , even though PKA alone did not regulate these promoters . Negative_regulation IGFBP1 PRKAR2A 10965886 728061 Conversely , a inhibitor ( H-89 ) *inhibited* the ability of cAMP , but not IL-1beta to stimulate [IGFBP-1] synthesis . Negative_regulation IGFBP1 PRKAR2A 11874707 918808 We have now investigated the responses to activation and *inhibition* of [PP1/2A] and used PTP inhibitors to examine the relationship between the morphological changes and enhanced steroid production . Negative_regulation IGFBP1 PRKAR2A 15604115 1380780 and Dex also synergistically induced a minimal 3 x glucocorticoid response element promoter , but *inhibited* Dex induction of the mouse mammary tumor virus and [IGF binding protein 1] promoters , even though PKA alone did not regulate these promoters . Negative_regulation IGFBP1 PRKAR2B 10965886 728062 Conversely , a inhibitor ( H-89 ) *inhibited* the ability of cAMP , but not IL-1beta to stimulate [IGFBP-1] synthesis . Negative_regulation IGFBP1 PRKAR2B 11874707 918809 We have now investigated the responses to activation and *inhibition* of [PP1/2A] and used PTP inhibitors to examine the relationship between the morphological changes and enhanced steroid production . Negative_regulation IGFBP1 PRKAR2B 15604115 1380781 and Dex also synergistically induced a minimal 3 x glucocorticoid response element promoter , but *inhibited* Dex induction of the mouse mammary tumor virus and [IGF binding protein 1] promoters , even though PKA alone did not regulate these promoters . Negative_regulation IGFBP1 RELA 9575170 502601 This differential induction of iNOS as compared with similar *activation* of by inhibitors of [PP 1/2A] indicates the involvement of different intracellular signaling events for the induction of iNOS in two cell types of the same animal species . Negative_regulation IGFBP1 TCF12 10702299 672598 The forkhead rhabdomyosarcoma ( FKHR ) is a promising candidate to be the transcription factor that binds to the insulin response element of the insulin-like growth factor binding protein-1 ( IGFBP-1 ) promoter and *mediates* insulin inhibition of [IGFBP-1] promoter activity . Negative_regulation IGFBP1 TCF15 10702299 672599 The forkhead rhabdomyosarcoma ( FKHR ) is a promising candidate to be the transcription factor that binds to the insulin response element of the insulin-like growth factor binding protein-1 ( IGFBP-1 ) promoter and *mediates* insulin inhibition of [IGFBP-1] promoter activity . Negative_regulation IGFBP1 TCF19 10702299 672600 The forkhead rhabdomyosarcoma ( FKHR ) is a promising candidate to be the transcription factor that binds to the insulin response element of the insulin-like growth factor binding protein-1 ( IGFBP-1 ) promoter and *mediates* insulin inhibition of [IGFBP-1] promoter activity . Negative_regulation IGFBP1 TCF20 10702299 672601 The forkhead rhabdomyosarcoma ( FKHR ) is a promising candidate to be the transcription factor that binds to the insulin response element of the insulin-like growth factor binding protein-1 ( IGFBP-1 ) promoter and *mediates* insulin inhibition of [IGFBP-1] promoter activity . Negative_regulation IGFBP1 TCF21 10702299 672602 The forkhead rhabdomyosarcoma ( FKHR ) is a promising candidate to be the transcription factor that binds to the insulin response element of the insulin-like growth factor binding protein-1 ( IGFBP-1 ) promoter and *mediates* insulin inhibition of [IGFBP-1] promoter activity . Negative_regulation IGFBP1 TCF23 10702299 672606 The forkhead rhabdomyosarcoma ( FKHR ) is a promising candidate to be the transcription factor that binds to the insulin response element of the insulin-like growth factor binding protein-1 ( IGFBP-1 ) promoter and *mediates* insulin inhibition of [IGFBP-1] promoter activity . Negative_regulation IGFBP1 TCF24 10702299 672608 The forkhead rhabdomyosarcoma ( FKHR ) is a promising candidate to be the transcription factor that binds to the insulin response element of the insulin-like growth factor binding protein-1 ( IGFBP-1 ) promoter and *mediates* insulin inhibition of [IGFBP-1] promoter activity . Negative_regulation IGFBP1 TCF25 10702299 672607 The forkhead rhabdomyosarcoma ( FKHR ) is a promising candidate to be the transcription factor that binds to the insulin response element of the insulin-like growth factor binding protein-1 ( IGFBP-1 ) promoter and *mediates* insulin inhibition of [IGFBP-1] promoter activity . Negative_regulation IGFBP1 TCF3 10702299 672603 The forkhead rhabdomyosarcoma ( FKHR ) is a promising candidate to be the transcription factor that binds to the insulin response element of the insulin-like growth factor binding protein-1 ( IGFBP-1 ) promoter and *mediates* insulin inhibition of [IGFBP-1] promoter activity . Negative_regulation IGFBP1 TCF4 10702299 672604 The forkhead rhabdomyosarcoma ( FKHR ) is a promising candidate to be the transcription factor that binds to the insulin response element of the insulin-like growth factor binding protein-1 ( IGFBP-1 ) promoter and *mediates* insulin inhibition of [IGFBP-1] promoter activity . Negative_regulation IGFBP1 TCF7 10702299 672605 The forkhead rhabdomyosarcoma ( FKHR ) is a promising candidate to be the transcription factor that binds to the insulin response element of the insulin-like growth factor binding protein-1 ( IGFBP-1 ) promoter and *mediates* insulin inhibition of [IGFBP-1] promoter activity . Negative_regulation IGFBP1 TEAD4 22843786 2676999 Insulin prevented expression and significantly *inhibited* [IGFBP-1] transcription in endothelial cells in a dose dependent fashion . Negative_regulation IGFBP1 TGFB1 7512498 250348 ( 5 ng/ml ) *suppressed* [IGFBP] levels ( CM [ 125I ] IGF-I binding capacity ) in L6 and BC3H-1 cell media by 48 % and 61 % , respectively . Negative_regulation IGFBP1 TNF 12394292 1008591 However , the alcohol induced increase in [IGFBP-1] was *attenuated* by ( BP ) . Negative_regulation IGFBP1 TSHB 1722684 173727 The constitutive secretion of [IGFBP] was *inhibited* by ( TSH , 0.3 mU per mL ) . Negative_regulation IGFBP2 IGFBP1 7522843 272149 Both and IGFBP-2 increased with starvation but while IGFBP-1 levels returned to control values following both insulin and glucose infusion , levels of [IGFBP-2] were not *reduced* significantly by either infusion or by refeeding . Negative_regulation IGFBP2 IL1B 14656210 1176867 On day 4 , ( 1 ng/ml ) and IL-6 ( 10 and 50 ng/ml ) *reduced* [IGFBP-2] by 29+/-8 % , and by 32+/-9 and 38+/-8 % respectively ( P < 0.05 ) . Negative_regulation IGFBP2 IL1B 14656210 1176871 Both [IGFBP-2] and IGFBP-4 were *reduced* by and IL-6 in combination at 1 and 10 ng/ml ( P < 0.05 ) . Negative_regulation IGFBP3 FOXA1 22879989 2641661 An increase in [IGFBP-3] , *mediated* by depletion of , inhibited phosphorylation of MAPK and Akt , and increased expression of the cell cycle regulators p21 and p27 . Negative_regulation IGFBP3 IGFBP1 8626847 361070 We speculate that low serum IGF-I and [IGFBP-3] levels would be partially *due* to the increased urinary losses of serum complexes , especially that of 150 kDa , and these changes may contribute to growth failure in persistent nephrotic syndrome . Negative_regulation IGFBP3 IGFBP1 9135573 427819 and IGFBP-3 , but not an N-terminal fragment of IGFBP-3 , could effectively *block* binding of both IGF-I and IGF-II to the solid-phase [IGFBP-3] . Negative_regulation IGFBP3 IL1B 12054123 581436 Both and TNF-alpha *inhibited* [IGFBP-3] ( 42/38 KDa species ) production in a concentration dependent manner judged by Western ligand blot . Negative_regulation IGFBP3 IL1B 9449037 475366 In all cultures of marrow from postmenopausal women , *suppressed* [IGFBP-3] secretion to either undetectable levels or levels between 11 % and 35 % of control . Negative_regulation IGFBP3 PLAU 17121915 1652265 The specific *role* of in anti-invasive activity of [IGFBP-3] was further confirmed in NSCLC cells , in which uPA expression/activity was suppressed by the transfection with synthetic small interfering RNA or by the treatment with uPA inhibitor or induced by the infection with an adenoviral vector . Negative_regulation IGFBP3 TNF 12054123 581435 Both IL-1beta and *inhibited* [IGFBP-3] ( 42/38 KDa species ) production in a concentration dependent manner judged by Western ligand blot . Negative_regulation IGFBP3 TNF 12599210 1062191 The *induced* decrease in [IGFBP-3] production and inhibition of differentiation could not be rescued by addition of IGF-I . Negative_regulation IGFBP3 TNF 7684061 216611 TNF-alpha caused a dose dependent decrease in fibroblast IGFBP-3 secretion , 1 microgram *reducing* [IGFBP-3] levels to 32.1 +/- 11. % of control . Negative_regulation IGFBP3 TP63 15781645 1385834 Disruption of expression in squamous epithelial cells *increases* [IGFBP-3] expression , whereas ectopic expression of DeltaNp63alpha down-regulates IGFBP-3 . Negative_regulation IGFBP4 IL1B 10433204 633940 Our findings also suggest , by inference , that the *mediated* inhibition of [IGFBP-4] and -5 transcripts is due in part to a decrease in the rate of transcription of the corresponding genes and not to a change in the stability of the relevant messenger RNAs . Negative_regulation IGFBP4 IL1B 14656210 1176873 Both IGFBP-2 and [IGFBP-4] were *reduced* by and IL-6 in combination at 1 and 10 ng/ml ( P < 0.05 ) . Negative_regulation IGFBP4 IL1B 23971193 2832830 *caused* a decrease in [IGFBP-4] and IGFBP-6 levels and a marked increase in IGFBP-5 . Negative_regulation IGFBP4 TNF 21957737 2488228 and IFN-gamma *attenuated* the expression of [IGFBP-4] and -6 under basal conditions and in the presence of IGF-I , and inhibited IGF-I induced IGFBP-5 expression during 5-day myogenesis . Negative_regulation IGFBP4 TNF 7522842 272148 The presence of ( 600 pmol/l ) *inhibited* this calcitriol induced stimulation of [IGFBP-4] mRNA levels from 4 h onwards , with complete inhibition of the calcitriol effect occurring at 24 h . Negative_regulation IGFBP5 IL1B 10433204 633941 Our findings also suggest , by inference , that the mediated *inhibition* of [IGFBP-4 and -5] transcripts is due in part to a decrease in the rate of transcription of the corresponding genes and not to a change in the stability of the relevant messenger RNAs . Negative_regulation IGFBP5 IL1B 23971193 2832831 *caused* a decrease in IGFBP-4 and IGFBP-6 levels and a marked increase in [IGFBP-5] . Negative_regulation IGFBP5 TNF 10797307 689842 All treatments suppressed IGF-II production but only *blocked* [IGFBP-5] secretion . Negative_regulation IGFBP5 TNF 21957737 2488232 and IFN-gamma attenuated the expression of IGFBP-4 and -6 under basal conditions and in the presence of IGF-I , and *inhibited* IGF-I induced [IGFBP-5] expression during 5-day myogenesis . Negative_regulation IGFBP6 IL1B 23971193 2832832 *caused* a decrease in IGFBP-4 and [IGFBP-6] levels and a marked increase in IGFBP-5 . Negative_regulation IGFBP6 TNF 21957737 2488237 and IFN-gamma *attenuated* the expression of [IGFBP-4 and -6] under basal conditions and in the presence of IGF-I , and inhibited IGF-I induced IGFBP-5 expression during 5-day myogenesis . Negative_regulation IGKV1-27 TNF 16105945 1448385 The synergistic interaction between fXa and was also *involved* in the inhibition of [A20] and IkappaBalpha expression in the IkappaB kinase-NF-kappaB pathway . Negative_regulation IKBKB ARSA 16199534 1483155 Biochemical analysis revealed that inhibited NF-kappaB activity , which is known to regulate BCL-2 gene expression , by dephosphorylating IkappaB-alpha and *inhibiting* [IKKbeta] activity but not by affecting the HER-2/neu phosphatidylinositol 3-kinase-Akt signal pathway . Negative_regulation IKBKB EGLN3 23732909 2811909 Instead , interaction with IKK? is required for the ability of to *inhibit* IKK? ubiquitination and [IKK-NF-?B] signaling . Negative_regulation IKBKB EPHB2 14604964 1209549 The antigen induced tyrosine phosphorylation of FcepsilonRI , Syk , phospholipase C-gamma (PLC-gamma) , activation of c-Jun N-terminal kinase (JNK) , extracellular signal regulated kinase ( ) , *inhibitor* of nuclear factor kappaB kinase ( [IKK] ) , and Ca++ influx were all suppressed in the cells overexpressing Cbl-b in the lipid raft . Negative_regulation IKBKB FAS 20212524 2223113 We validated experimentally that stimulation *resulted* in an interaction of p43-FLIP with the [IKK complex] followed by its activation . Negative_regulation IKBKB TLR7 22037600 2508152 signaling *activates* the inhibitor of transcription factor NF-?B ( I?B ) kinase ( [IKK) complex] , which governs NF-?B mediated transcription during inflammation . Negative_regulation IKBKB TLR7 24251781 2903784 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , PI3K/AkT inhibition , [IKK/JNK] *inhibition* , mTORC1 inhibition , JAK/STAT inhibition , suppression , and ACE inhibition . Negative_regulation IKBKB TNF 16774932 1672073 PMA selectively causes the degradation of IkappaB kinases ( IKKs ) including IKK-gamma and IKK-beta , and subsequent inhibition of *induced* [IKK] and NF-kappaB activation in human colon cancer cell line HCT-116 , but not in other gastrointestinal tract cells . Negative_regulation IKBKB TNF 16935850 1673063 Using knockout mice and hepatic-specific *inhibition* of [IKKbeta] , we demonstrate that the status of TNF-alpha and NF-kappaB balances necrotic and apoptotic fates of hepatocytes in the setting of endotoxemia . Negative_regulation IKBKB TNF 18346759 1892210 We demonstrated that stimulates IkappaB-alpha phosphorylation through induction of IKK activity , and that fenofibrate *inhibits* [IKK] activity and TNFalpha induced IkappaB-alpha phosphorylation . Negative_regulation IKBKB TNF 24215713 2897255 Moreover , classical NF-?B activation ( both by and IKK-ß over-expression ) *reduced* [IKK-a] levels and IKK-a over-expression prevented TNF-a induced impairments in muscle OXPHEN . Negative_regulation IKBKB TNF 24215713 2897258 *induced* reductions in muscle [IKK-a] may accelerate muscle OXPHEN deterioration in COPD . Negative_regulation IKBKG EGLN3 23732909 2811910 Instead , interaction with IKK? is required for the ability of to *inhibit* IKK? ubiquitination and [IKK-NF-?B] signaling . Negative_regulation IKBKG EPHB2 14604964 1209550 The antigen induced tyrosine phosphorylation of FcepsilonRI , Syk , phospholipase C-gamma (PLC-gamma) , activation of c-Jun N-terminal kinase (JNK) , extracellular signal regulated kinase ( ) , *inhibitor* of nuclear factor kappaB kinase ( [IKK] ) , and Ca++ influx were all suppressed in the cells overexpressing Cbl-b in the lipid raft . Negative_regulation IKBKG FAS 20212524 2223114 We validated experimentally that stimulation *resulted* in an interaction of p43-FLIP with the [IKK complex] followed by its activation . Negative_regulation IKBKG TLR7 22037600 2508162 signaling *activates* the inhibitor of transcription factor NF-?B ( I?B ) kinase ( [IKK) complex] , which governs NF-?B mediated transcription during inflammation . Negative_regulation IKBKG TLR7 24251781 2903813 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , PI3K/AkT inhibition , [IKK/JNK] *inhibition* , mTORC1 inhibition , JAK/STAT inhibition , suppression , and ACE inhibition . Negative_regulation IKBKG TNF 16399796 1520242 Skin lesion development in a mouse model of incontinentia pigmenti is triggered by [NEMO] deficiency in epidermal keratinocytes and *requires* signaling . Negative_regulation IKBKG TNF 16774932 1672074 PMA selectively causes the degradation of IkappaB kinases ( IKKs ) including IKK-gamma and IKK-beta , and subsequent inhibition of *induced* [IKK] and NF-kappaB activation in human colon cancer cell line HCT-116 , but not in other gastrointestinal tract cells . Negative_regulation IKBKG TNF 17314097 1719504 Interestingly , peptides spanning CCR2 and/or LZ disrupt [IKKgamma-Tax] and IKKgamma-PP2A interactions and potently *inhibit* NF-kappaB activation by Tax and . Negative_regulation IKBKG TNF 18346759 1892211 We demonstrated that stimulates IkappaB-alpha phosphorylation through induction of IKK activity , and that fenofibrate *inhibits* [IKK] activity and TNFalpha induced IkappaB-alpha phosphorylation . Negative_regulation IKBKG TNF 24215713 2897256 Moreover , classical NF-?B activation ( both by and IKK-ß over-expression ) *reduced* [IKK-a] levels and IKK-a over-expression prevented TNF-a induced impairments in muscle OXPHEN . Negative_regulation IKBKG TNF 24215713 2897259 *induced* reductions in muscle [IKK-a] may accelerate muscle OXPHEN deterioration in COPD . Negative_regulation IL10 ABCA4 11809739 906506 The elicited a reciprocal response , i.e. elevated IL-12 and NO production , and *reduced* IL-6 and [IL-10] production . Negative_regulation IL10 CD14 19841036 2209520 The proinflammatory cytokines TNF-alpha , IL-1beta , IL-6 , and IL-8 , but not the anti-inflammatory cytokine [IL-10] , were efficiently *inhibited* by . Negative_regulation IL10 CD14 20946675 2337957 Blocking in monocytes *inhibited* secretion of interleukin (IL)-1ß ( 72 % ) , IL-6 ( 58 % ) and [IL-10] ( 63 % ) , and blocking TLR4 inhibited secretion of IL-1ß by 67 % , IL-6 by 63 % and IL-10 by 60 % . Negative_regulation IL10 CST6 23174104 2740844 Ex vivo restimulation with cystatin of spleen cells from cystatin treated mice *induced* the production of [IL-10] , while inhibited allergen-specific IL-5 and IL-13 levels . Negative_regulation IL10 EPHB2 11971021 933497 Studies using rIL-10 and IL-10 gene-deficient mice demonstrated that the inhibitory effect of ERK on CpG DNA mediated IL-12 production is indirect , due to the *role* of in mediating [IL-10] production . Negative_regulation IL10 EPHB2 12112010 963586 Thus , we speculate that during inflammatory conditions in vivo macrophage p38 may regulate JNK and activity and *inhibit* [IL-10] expression . Negative_regulation IL10 EPHB2 12594849 1061101 or JNKinhibitors partially *inhibited* IL-4 and [IL-10] secretion , while PKC or p38 inhibitors had no significant effects on IL-4 or IL-10 secretion . Negative_regulation IL10 EPHB2 16818788 1581372 Blocking the activation of *prevented* histone phosphorylation and transcription factor binding to the [IL-10] promoter . Negative_regulation IL10 EPHB2 16824602 1666060 A specific inhibitor , U0126 , as well as PI3K inhibitors , differentially *regulated* [IL-10] and IL-12 p70 productions . Negative_regulation IL10 EPHB2 20190136 2229227 The effect of these teichoic acids on [IL-10] production was *mediated* by TLR2 dependent activation . Negative_regulation IL10 EPHB2 22579699 2614252 Additionally , CA treatment induced and JNK phosphorylation , and unexpectedly , elevated levels of [IL-10] and TGF-ß were *inhibited* by the addition of an ERK-specific inhibitor . Negative_regulation IL10 FAS 11069082 747696 Here we demonstrate that receptor engagement *results* in the induction of the [IL-10] gene in monocytes , but not in lymphocytes or dendritic cells . Negative_regulation IL10 FAS 16314469 1487018 Only markedly *diminished* lung tissue tumor necrosis factor-alpha , IL-6 , [IL-10] , interferon-gamma , IL-12 , and caspase-3 activity . Negative_regulation IL10 FAS 24431281 2901343 Taken together , our findings indicate that impaired signaling *results* in enhanced expression of antiinflammatory [IL-10] and reduced expression of gp96 , and these effects are associated with accelerated resolution of inflammation during the chronic phase of arthritis . Negative_regulation IL10 HRH1 15021962 1221737 Depletion of the *resulted* in decreases in the release of IL-2 and [IL-10] from both CD4+ and CD8+ cells and increases in the release of IL-4 from CD4+ T cells and IFN-gamma from CD8+ cells . Negative_regulation IL10 IL1B 11437211 832740 These observations are the first to demonstrate that TENS antagonizes IL-1beta actions on PDL cells by ( i ) inhibiting induced transcriptional regulation of proinflammatory cytokines , and ( ii ) *inducing* synthesis of [IL-10] , which may post-transcriptionally suppress the synthesis of pro-inflammatory cytokines . Negative_regulation IL10 IL1B 11849236 912759 The presence of the antigen presenting cell (APC) derived cytokine *inhibited* [IL-10] production by cord blood cells . Negative_regulation IL10 IL1B 12010759 941265 We conclude that [IL-10] modulates the febrile response by acting in the periphery or in the brain dependent on the primary site of inflammation and that its mechanism of action most likely *involves* inhibition of local production . Negative_regulation IL10 IL1B 12384141 998581 Simultaneously , however , G-CSF pretreatment apparently *enhanced* LPS induced secretion of [IL-10] and monocyte chemoattractant protein-1 , whereas secretions of , IL-6 , and IL-8 were unaffected . Negative_regulation IL10 IL1B 14699427 1250759 *induced* suppression of mitogen stimulated release of the anti-inflammatory cytokine [IL-10] was also blocked by treatment with ethyl-EPA . Negative_regulation IL10 IL1B 15826869 1403876 In contrast to living bacteria , it had no effect on the release , but it *induced* [IL-10] secretion . Negative_regulation IL10 IL1B 15949713 1421345 The results indicate that serum levels of and IL-10 *increased* significantly after the intraportal infusion of NE. Co-administration of NE and YHB , however , significantly attenuated IL-1beta and [IL-10] production . Negative_regulation IL10 IL1B 15972630 1423996 TMA *induced* early expression of [IL-10] , a cytokine implicated in the negative regulation of Langerhans cell ( LC ) migration , whereas exposure to DNCB resulted in production of the proinflammatory cytokine . Negative_regulation IL10 IL1B 20159741 2208560 Tylosin at 500 mg/kg had no effect on TNFalpha or production , but it *induced* [IL10] production in healthy mice . Negative_regulation IL10 IL1B 20456417 2288477 In the presence of LPS , LcS enhanced production but *inhibited* LPS induced [IL-10] and IL-6 production , and had no further effect on TNF-alpha and IL-12 production . Negative_regulation IL10 IL1B 9488420 488732 Addition of a monoclonal antibody which binds the Cryptococcus neoformans capsule to suspensions of human monocytes , T lymphocytes , and cryptococcal cells ( i ) enhances , tumor necrosis factor alpha , and IL-2 production; (ii) *reduces* [IL-10] secretion ; Negative_regulation IL10 KLF9 14976188 1236081 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL10 RAB31 7876537 298695 The experiments reported here indicate that also *inhibited* the expression of IL-4 , IL-6 , and [IL-10] , thereby raising the possibility that the blockade of IL-9 production by anti-IL-2R mAb could be secondary to the blockade of these cytokines . Negative_regulation IL10 TLR7 19191102 2033509 Prior studies by the authors revealed that ligands *inhibit* [IL-10] receptor signaling in alveolar macrophages ( AMØs ) , thereby obviating the immunosuppressive activity of IL-10 . Negative_regulation IL10 TLR7 20677943 2305480 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL10 TLR7 22685319 2675987 Interestingly , despite expression of TLR mRNA on Kupffer cells , ligation of TLR4 , , and TLR9 *resulted* in a weak induction of [IL-10] , low or undetectable levels of IL-12p40 and TNF , and up-regulation of CD40 on the surface . Negative_regulation IL10 TNF 10233738 611570 The failure of IL-4 to regulate [IL-10] production is not *due* to the failure of IL-4 to suppress , and vice versa . Negative_regulation IL10 TNF 10374812 623164 Opposite to IFN-gamma , the lipid mediator prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of [IL-10] and *inhibited* that of . Negative_regulation IL10 TNF 10880840 709213 TGF-beta1 *induced* [IL-10] production , slightly decreased production and decreased IFN-gamma production . Negative_regulation IL10 TNF 11001546 734538 Human recombinant ( 25 ng/mL ) added during the activation culture *resulted* in a two-fold increase in interferon-gamma release ( type 1 response ) and a significant reduction of [interleukin-10] ( type 2 response ) after tumor antigen stimulation . Negative_regulation IL10 TNF 11686517 875869 Moreover , we demonstrated that M. furfur modulates proinflammatory and immunomodulatory cytokine synthesis by downregulating IL-1alpha and by *inhibiting* IL-6 and and by upregulating [IL-10] and TGF-beta1 . Negative_regulation IL10 TNF 11927652 927106 Stimulation of DC with IFN-gamma increased the release of interleukin (IL)-12 and and *inhibited* the production of [IL-10] . Negative_regulation IL10 TNF 11958828 931306 Estriol was also found to alter the cytokine profile of T cells toward Th2 phenotype by up-regulating the production of [IL-10] and *inhibiting* secretion of T cells . Negative_regulation IL10 TNF 12193748 981559 HAT partially inhibited production of and completely *inhibited* production of IL-4 , IL-5 , and [IL-10] . Negative_regulation IL10 TNF 12450578 1020488 SSR125329A inhibited staphylococcal enterotoxin B-induced mouse splenocyte proliferation in vitro , whereas in vivo it *enhanced* lipopolysaccharide induced systemic release of [interleukin-10] while simultaneously inhibiting synthesis . Negative_regulation IL10 TNF 12826081 1104535 GXM *enhanced* the secretion of [IL-10] and IL-4 , while it reduced the production of pro-inflammatory cytokines and IFN-gamma . Negative_regulation IL10 TNF 14717910 1197526 Basal- and Con-A stimulated interleukin (IL)-6 , IL-10 , interferon (IFN)-gamma , and levels were similar in control and INS patients , and all cytokines but [IL-10] were significantly *inhibited* by Dex 10-6 mol/L . Negative_regulation IL10 TNF 14754421 1205570 Thirdly , capsular polysaccharides enhance the production of anti-inflammatory [interleukin-10 (IL-10)] and *induce* receptor loss from the surface of neutrophils . Negative_regulation IL10 TNF 14975587 1212886 In unseparated macrophages ( MPhi ) and MPhi of low density , GLAT *enhanced* constitutive and LPS induced production of [interleukin 10 (IL-10)] while LPS induced synthesis of was dose-dependently suppressed by GLAT . Negative_regulation IL10 TNF 15145612 1247727 Endogenous catecholamine , epinephrine and norepinephrine , and isoproterenol concentration-dependently induced the production of interleukin (IL)-18 , and interferon (IFN)-gamma , and *inhibited* that of [IL-10] in human peripheral blood mononuclear cells ( PBMC ) . Negative_regulation IL10 TNF 16226132 1469671 Garlic increases [IL-10] and *inhibits* and IL-6 production in endotoxin stimulated human placental explants . Negative_regulation IL10 TNF 16275760 1480226 We further revealed the following three novel functional properties of OX40L : ( a) OX40L selectively promoted , but *inhibited* [IL-10] production in developing Th2 cells ; Negative_regulation IL10 TNF 16371225 1512437 The adenosine A(1) receptor antagonist inhibited TNF-alpha , IL-10 , and RANTES , adenosine A(2B) receptor antagonist inhibited and RANTES , and adenosine A(3) receptor antagonist *inhibited* [IL-10] and RANTES . Negative_regulation IL10 TNF 16380168 1533333 We tested the cytokine production of rat and mouse macrophages in vitro and found that internalization of SPIO/USPIO shifted macrophages towards an anti-inflammatory , less responsive phenotype by enhancing [interleukin (IL)-10] and *inhibiting* production . Negative_regulation IL10 TNF 16610053 1545264 The level of was elevated and the level of [IL-10] was *reduced* . Negative_regulation IL10 TNF 16888021 1596828 We previously reported that acute alcohol treatment augments [IL-10] and *inhibits* production in monocytes . Negative_regulation IL10 TNF 16888021 1596855 In LPS challenged mice in vivo , both acute alcohol administration and HO-1 activation augmented [IL-10] and *inhibited* serum levels . Negative_regulation IL10 TNF 17045026 1635691 IL-7 and IL-15 could affect the balance between Th1 and Th2 cytokines by inducing IFN-gamma and production and *inhibiting* IL-4 and [IL-10] expression . Negative_regulation IL10 TNF 17253143 1704057 Retinoic acid *enhances* the production of [IL-10] while reducing the synthesis of IL-12 and from LPS stimulated monocytes/macrophages . Negative_regulation IL10 TNF 17261545 1710487 Anti-FasL , but not or anti-TRAIL , *blocked* activation induced cell death of CD8 T cells and increased secretion of [IL-10] and IL-4 by CD4 T cells from T. cruzi infected mice . Negative_regulation IL10 TNF 17537727 1767283 Short-term treatment of RAW264.7 macrophages with adiponectin increases tumor necrosis factor-alpha (TNF-alpha) expression via ERK1/2 activation and Egr-1 expression : *role* of in adiponectin stimulated [interleukin-10] production . Negative_regulation IL10 TNF 17569361 1668971 In normal PBMC , emodin attenuated TNF-alpha and [IL-10] release in response to LPS , and SMI significantly *inhibited* release . Negative_regulation IL10 TNF 17592223 1768208 In contrast , acute alcohol treatment augmented NF-kappaB activation and production and *inhibited* [IL-10] levels in the presence of complex stimulation with combined TLR2 and TLR4 ligands . Negative_regulation IL10 TNF 18325328 1886210 A membrane proximal ITIM mutant of Siglec-9 did not enhance [IL-10] production but partly *inhibited* production , indicating diverse regulation mechanisms of TNF-alpha and IL-10 . Negative_regulation IL10 TNF 18707743 1961520 The 4 component system inhibited the production of the pro-inflammatory cytokine , and the Hp fraction *inhibited* the anti-inflammatory cytokine [interleukin-10 (IL-10)] . Negative_regulation IL10 TNF 19014336 2022449 Phytohemagglutinin stimulation in combination with bovine CPC significantly increased the secretion of [IL-10] and IL-2 at 6 h of culture and *inhibited* IFN-gamma and ( p < 0.05 ) . Negative_regulation IL10 TNF 19084112 2003534 Relm-alpha coactivated IL-6 and release and *inhibited* [IL-10] release from LPS activated bone marrow derived macrophages . Negative_regulation IL10 TNF 19410299 2128186 Zymosan enhanced dectin-1/TLR2/TLR4 expression and TNF-alpha/IL-10 production in all of three types of cell , whereas p-beta-glucan increased dectin-1/TLR4 and production in AMs but *inhibited* [IL-10] in mDCs . Negative_regulation IL10 TNF 19528220 2121071 Further , adding autolyzed pneumococci to intact bacteria inhibited production of , IFN-gamma , and IL-12 in a dose dependent manner but did not *inhibit* production of IL-6 , IL-8 , and [IL-10] in response to the intact bacteria . Negative_regulation IL10 TNF 19536644 2121137 On the contrary , SF from osteoarthritis patients did not favor osteoclastogenesis and exerted an anti-inflammatory effect through [IL-10] upregulation and *inhibition* . Negative_regulation IL10 TNF 19703147 2133356 Urocortin treatment *induced* a significant and dose dependent increase of IL-4 and [IL-10] , whereas it did not affect secretion . Negative_regulation IL10 TNF 20564507 2345403 Moreover , HSYA decreased NF-?B p65 nuclear translocation , *inhibited* proinflammatory cytokine , IL-1ß and IL-6 mRNA expression and promoted antiinflammatory cytokine [IL-10] gene expression following LPS injection . Negative_regulation IL10 TNF 20640531 2479908 The PKA specific agonist N6-benzoyladenosine-3,5-cAMP ( 6-Bnz-cAMP ) not only inhibited the transcription and production of tumor necrosis factor-a (TNF-a) and interleukin-1ß (IL-1ß) but also *enhanced* the transcription and expression of [IL-10] , while the Epac selective analog 8- ( 4-chlorophenylthio ) -2-O-methyladenosine-3,5-cAMP ( 8-pCPT-2'-O-Me-cAMP ) merely repressed the expression . Negative_regulation IL10 TNF 20881185 2337361 Exosomes from Leishmania donovani modulated human monocyte cytokine responses to IFN-? in a bimodal fashion by promoting [IL-10] production and *inhibiting* that of . Negative_regulation IL10 TNF 20979991 2365423 In the present study , we examined the *role* of in [interleukin (IL)-10] production by dendritic cells (DCs) using bone-marrow derived DCs from wild type ( WT ) and TNF-a knockout ( TNF-a ( -/- ) ) mice . Negative_regulation IL10 TNF 22956783 2684028 Abundance of miR-181a attenuated ox-LDL induced CD83 and CD40 expression , *inhibited* the secretion of interleukin (IL)-6 and , and up-regulated [IL-10] , an important anti-inflammatory cytokine that was inhibited by ox-LDL . Negative_regulation IL10 TNF 23256797 2718629 UA markedly rescued lethality , improved survival time and lung pathological changes , *inhibited* , IL-6 , IL-1ß , HMGB1 and NO , and increased [IL-10] expression . Negative_regulation IL10 TNF 23499643 2766632 Mechanistically , MSCs derived PGE2 , through the receptors EP2 and EP4 , promoted the release of [IL-10] and *inhibited* the production of IL-6 and by macrophages . Negative_regulation IL10 TNF 23742617 2807062 Regarding the antinociceptive mechanisms of 1 , it prevented the decrease of reduced glutathione levels , ferric reducing ability potential , and free-radical scavenger ability , *inhibited* the production of hyperalgesic cytokines such as , IL-1ß , IL-6 , and IL-33 , and up-regulated the levels of the anti-hyperalgesic cytokine [IL-10] . Negative_regulation IL10 TNF 23791971 2834340 The in vitro studies revealed that ZL-5015 greatly inhibited the production of NO , PGE2 and , slightly *promoted* [IL-10] production and suppressed the splenocyte proliferation stimulated by Con A or LPS at the concentrations from 10 to 40µM . Negative_regulation IL10 TNF 24048901 2851782 Our findings suggest that activated platelets have anti-inflammatory properties related to the interaction between CD40L and CD40 , and exert a hitherto undescribed immunoregulatory action by enhancing [IL-10] production and *inhibiting* production by monocytes . Negative_regulation IL10 TNF 7590660 330085 Cells from cirrhotic patients were normally responsive to recombinant [IL-10] , which *induced* a dose dependent decrease of secretion . Negative_regulation IL10 TNF 7964475 279562 To assess the *role* of in the induction of [IL-10] in endotoxemia , four healthy men were studied after a bolus intravenous injection of recombinant human TNF ( 50 micrograms/m2 ) . Negative_regulation IL10 TNF 8258695 238782 Predominant *role* of in human monocyte [IL-10] synthesis . Negative_regulation IL10 TNF 8666814 369121 Adenosine also significantly enhanced [IL-10] production after hydrogen peroxide and LPS stimulation and dose-dependently *inhibited* secretion . Negative_regulation IL10 TNF 8742066 377134 LPS stimulated release of declined substantially after the first day and was consistently *suppressed* by [IL-10] and IL-4 but increased by IFN-gamma . Negative_regulation IL10 TNF 8833901 385995 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL10 TNF 8957229 401618 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL10 TNF 9449707 483967 IL-18 did not *induce* antiinflammatory cytokines , IL-1Ra , or [IL-10] , although IL-18 induction of was inhibited by IL-10 . Negative_regulation IL10 TNF 9498794 490643 CD137 protein induces expression of IL-6 , IL-8 , and , and *inhibits* expression of [IL-10] . Negative_regulation IL10 TNF 9822893 548972 We have recently observed that the selective adenosine A3 receptor agonist N6- ( 3-iodobenzyl ) -adenosine-5'-N-methyluronamide ( IB-MECA ) augments [interleukin-10] and *inhibits* production in endotoxemic mice . Negative_regulation IL10 TNF 9927530 588641 We investigated the *role* of in the regulation of MHC class II antigens and cytokine mRNA expression of TNF , interferon-gamma (IFN) , IL-2 , IL-4 , and [IL-10] in cardiac allografts to elucidate its immunological mechanism . Negative_regulation IL10 TNFSF10 17261545 1710488 Anti-FasL , but not anti-TNF-alpha or , *blocked* activation induced cell death of CD8 T cells and increased secretion of [IL-10] and IL-4 by CD4 T cells from T. cruzi infected mice . Negative_regulation IL11 IL1B 12760902 1119664 and TGF-beta1 induced an activation of ERK p42/44 and p38 MAP kinases , and the MAP kinase inhibitors ( SB-202190 , PD-98059 , and U-0216 ) significantly *reduced* the IL-1beta- and TGF-beta1 induced [IL-11] secretion . Negative_regulation IL11 IL1B 16616208 1582994 The expression of IL-1beta , IL-8 , [IL-11] , and TNF-alpha receptors significantly decreased in the *presence* of after day 14 of culture , whereas the expression of IL-6 receptor significantly increased . Negative_regulation IL11 IL6R 9110148 425010 The with one mutated binding site to gp130 *inhibited* [IL-11] activity . Negative_regulation IL11 KLF9 14976188 1236098 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL11 TLR7 20677943 2305490 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL11 TNF 8833901 385996 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL11 TNF 8957229 401619 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL12A ADRB2 15336560 1291244 Down-regulation of expression by exercise training *increases* [IL-12] production by macrophages following LPS stimulation . Negative_regulation IL12A ADRB2 15998544 1459200 stimulation *inhibits* LPS induced IL-18 and [IL-12] production in monocytes . Negative_regulation IL12A ADRB2 9294119 452891 [IL-12] inhibition is *dependent* on stimulation and correlates with increased levels of intracellular cAMP . Negative_regulation IL12A ARSA 9808189 545151 was found to *inhibit* secretion of the [IL-12 heterodimer] as well as p40 monomer by human monocytic cells . Negative_regulation IL12A CST6 11238649 790864 mRNA expression and flow cytometric analysis of infected spleen cells suggested that and IFN-gamma treatment , in addition to greatly reducing parasite numbers , *resulted* in reduced levels of IL-4 but increased levels of [IL-12] and inducible NO synthase . Negative_regulation IL12A EPHB2 10586030 571622 In contrast , while p38 promotes induction of IL-12 ( p40 ) mRNA , activation *suppresses* LPS mediated [IL-12] transcription . Negative_regulation IL12A EPHB2 12828555 1104985 In addition , inhibition of by PD98059 significantly suppressed IL-10 and *increased* the [IL-12] production . Negative_regulation IL12A EPHB2 20851927 2388990 Inhibition of p38 , but not , *attenuated* production of both [IL12/IL23p40] and TNF-a . Negative_regulation IL12A EPHB2 22427889 2573177 The C-terminal region of p105 is necessary for LPS induced ERK activation and it has been suggested that activity *inhibits* both IFN-ß and [IL-12] p40 following LPS stimulation . Negative_regulation IL12A FAS 16314469 1487019 Only markedly *diminished* lung tissue tumor necrosis factor-alpha , IL-6 , IL-10 , interferon-gamma , [IL-12] , and caspase-3 activity . Negative_regulation IL12A GPNMB 17475886 1738534 overexpression in RAW264.7 cells *caused* a 2-fold reduction in the production of the cytokines IL-6 and [IL-12p40] and the inflammatory mediator NO in response to LPS . Negative_regulation IL12A IFI27 17702989 1788777 Overexpression of *enhanced* the LPS induced IkappaB-zeta , [IL-12p40] and NF-kappaB promoter activities , while anti-sense ( AS ) RNA against Ifi202 strongly suppressed them in a monocytic cell line , RAW 264.7 . Negative_regulation IL12A IFI27 17702989 1788807 Furthermore , overexpression of *enhanced* LPS induced [IL-12p40] and IkappaB-zeta mRNA induction while Ifi202 AS RNA suppressed these in RAW 264.7 cells . Negative_regulation IL12A ITGB2 11009109 735882 is also *involved* in reduction of [IL-12] release by L. major infected macrophages , as uptake of opsonized parasites ( via CR3 ) decreased IL-12 release only in WT , but not in CD18-/- macrophages . Negative_regulation IL12A SPHK1 21435724 2416932 Our data demonstrated that deficiency *enhanced* LPS induced [IL-12p70] production although SphK2 was present . Negative_regulation IL12A STAT4 11739505 886521 A mandatory *role* for in [IL-12] induction of mouse T cell CCR5 . Negative_regulation IL12A STAT4 21813204 2495446 Exposure of splenocytes to AEBSF for 3h noticeably *inhibited* the induction of IFN? , IL-12 , and IL-12 induced , mRNA expression of T-bet and [IL-12Rß2] . Negative_regulation IL12A STAT4 8700208 372998 To determine the function of and its *role* in [IL-12] signalling , we have produced mice that lack Stat4 by gene targeting . Negative_regulation IL12A TLR7 15611251 1357312 We also show that ES-62 *inhibits* [IL-12] induction by ligands other than LPS , bacterial lipopeptide ( TLR2 ) and CpG ( TLR9 ) , via this TLR4 dependent pathway . Negative_regulation IL12A TLR7 17918201 1819340 In this study , we investigated which mouse B cell subsets are the most potent cytokine producers , and examined the *role* of in the control of secretion of IL-6 , IL-10 , [IL-12] and IFN-gamma by B cells . Negative_regulation IL12A TLR7 18271077 1865808 Stimulation with TLR2 , TLR4 and ligands , as well as TLR3 ligand , *resulted* in significantly lower production of TNF-alpha , but neither IL-6 nor [IL-12p70] , by DCs from XLA patients in comparison to normal controls . Negative_regulation IL12A TLR7 20112371 2219496 Sigirr-deficient dendritic cells expressed higher TLR7 mRNA levels and activation *resulted* in increased [IL-12] production in vitro . Negative_regulation IL12A TLR7 20498209 2289121 Remarkably , the production of [IL-12] was lower upon *stimulation* with ligands in most patients with SSc , whereas the secretion of IL-10 was very high in patients with the dSSc phenotype , particularly in those having early dSSc . Negative_regulation IL12A TLR7 22536449 2590087 Here , we examine the *role* of and reactive oxygen species ( ROS ) in [IL-12] production by LAB stimulated peritoneal macrophages . Negative_regulation IL12A TLR7 22685319 2675990 Interestingly , despite expression of TLR mRNA on Kupffer cells , ligation of TLR4 , , and TLR9 *resulted* in a weak induction of IL-10 , low or undetectable levels of [IL-12p40] and TNF , and up-regulation of CD40 on the surface . Negative_regulation IL12A TLR7 22753939 2627272 We demonstrate that concurrent Notch and stimulation results in a unique cytokine profile in mouse bone-marrow derived DCs characterized by enhanced IL-10 and IL-2 , and *reduced* [IL-12] expression compared with TLR ligation alone . Negative_regulation IL12A TNF 10626665 658961 [IL-12] secretion by microglia is significantly *reduced* by and IFN-gamma antagonists showing that the IL-12 production is subject to regulation by auto- and paracrine stimuli . Negative_regulation IL12A TNF 10657616 664055 IL-10 is not responsible for the *mediated* inhibition of [IL-12] . Negative_regulation IL12A TNF 12377934 997044 Inhibition of [IL-12] by FcgammaR cross linking was not *mediated* by , as the presence of an anti-TNF-alpha Ab could not restore the reduced IL-12 production . Negative_regulation IL12A TNF 21545584 2435328 treatment *induced* a decrease in TNF-a , [IL-12p40] and IL-10 mRNA levels in peritoneal cells following PPD stimulation while live M. tuberculosis caused an increase in TNF-a mRNA and a decrease in the IL-10 mRNA expression . Negative_regulation IL12A TNF 21764089 2599152 The findings suggested that CSFV infection significantly increased the mRNA expression of IL-10 and , and *inhibited* [IL-12] expression , with little effect on IFN-a and IFN-? expression . Negative_regulation IL12A TNF 21830095 2495575 Tacrolimus completely inhibited IFN-? and production of activated T-cells in LPMCs , but only partially *inhibited* IFN-? , TNF-a , and [IL-12] production of activated monocytes/macrophages in LPMCs . Negative_regulation IL12A TNF 22798676 2639931 PLC activation enhanced the bactericidal activity and hydrogen peroxide production of mouse neutrophils , and it also *enhanced* the production of IFN-? and [IL-12] while inhibiting proseptic and IL-1ß production in cecal ligation and puncture mice . Negative_regulation IL12A TNF 22923002 2726418 Interestingly , , but not CGS21680 , dramatically *inhibited* [IL-12] mRNA expression . Negative_regulation IL12A TNF 23508772 2756969 This article will provide a summary of the cumulative pediatric safety and efficacy data for the anti-tumor necrosis factor-alpha ( ) agents and [interleukin (IL)-12] and IL-23 ( IL12/23 ) pathway *inhibitor* and suggestions for a rational clinical approach to their use in children with psoriasis . Negative_regulation IL12A TNF 8833901 386012 [IL-12] production is preceded by TNF-alpha production and is *inhibited* by recombinant soluble human receptor ( II ) -IgG1 fusion protein ( shu-TNF-R ) . Negative_regulation IL12A TNF 9394829 468226 We found that exogenously added *caused* a profound inhibition of monocytic [IL-12] secretion in the absence of IC , again mediated via the induction of IL-10 and PG . Negative_regulation IL12A TNF 9811882 545920 To determine whether *inhibition* of IFN-gamma induced [IL-12] production contributed to the resolution of an inflammatory response in vivo , the response of TNF+/+ and TNF-/- mice injected with Corynebacterium parvum were compared . Negative_regulation IL12A TP63 24047617 2888224 [IL12/23] *inhibition* ameliorates Alzheimer 's disease associated neuropathology and spatial memory in SAMP8 mice . Negative_regulation IL12B ADRB2 15336560 1291245 Down-regulation of expression by exercise training *increases* [IL-12] production by macrophages following LPS stimulation . Negative_regulation IL12B ADRB2 15998544 1459201 stimulation *inhibits* LPS induced IL-18 and [IL-12] production in monocytes . Negative_regulation IL12B ADRB2 9294119 452892 [IL-12] inhibition is *dependent* on stimulation and correlates with increased levels of intracellular cAMP . Negative_regulation IL12B ARSA 9808189 545152 was found to *inhibit* secretion of the [IL-12 heterodimer] as well as p40 monomer by human monocytic cells . Negative_regulation IL12B CST6 11238649 790874 mRNA expression and flow cytometric analysis of infected spleen cells suggested that and IFN-gamma treatment , in addition to greatly reducing parasite numbers , *resulted* in reduced levels of IL-4 but increased levels of [IL-12] and inducible NO synthase . Negative_regulation IL12B EPHB2 10586030 571623 In contrast , while p38 promotes induction of IL-12 ( p40 ) mRNA , activation *suppresses* LPS mediated [IL-12] transcription . Negative_regulation IL12B EPHB2 12828555 1104986 In addition , inhibition of by PD98059 significantly suppressed IL-10 and *increased* the [IL-12] production . Negative_regulation IL12B EPHB2 20851927 2388991 Inhibition of p38 , but not , *attenuated* production of both [IL12/IL23p40] and TNF-a . Negative_regulation IL12B EPHB2 22427889 2573178 The C-terminal region of p105 is necessary for LPS induced ERK activation and it has been suggested that activity *inhibits* both IFN-ß and [IL-12] p40 following LPS stimulation . Negative_regulation IL12B FAS 16314469 1487020 Only markedly *diminished* lung tissue tumor necrosis factor-alpha , IL-6 , IL-10 , interferon-gamma , [IL-12] , and caspase-3 activity . Negative_regulation IL12B GPNMB 17475886 1738535 overexpression in RAW264.7 cells *caused* a 2-fold reduction in the production of the cytokines IL-6 and [IL-12p40] and the inflammatory mediator NO in response to LPS . Negative_regulation IL12B IFI27 17702989 1788783 Overexpression of *enhanced* the LPS induced IkappaB-zeta , [IL-12p40] and NF-kappaB promoter activities , while anti-sense ( AS ) RNA against Ifi202 strongly suppressed them in a monocytic cell line , RAW 264.7 . Negative_regulation IL12B IFI27 17702989 1788813 Furthermore , overexpression of *enhanced* LPS induced [IL-12p40] and IkappaB-zeta mRNA induction while Ifi202 AS RNA suppressed these in RAW 264.7 cells . Negative_regulation IL12B ITGB2 11009109 735883 is also *involved* in reduction of [IL-12] release by L. major infected macrophages , as uptake of opsonized parasites ( via CR3 ) decreased IL-12 release only in WT , but not in CD18-/- macrophages . Negative_regulation IL12B SPHK1 21435724 2416933 Our data demonstrated that deficiency *enhanced* LPS induced [IL-12p70] production although SphK2 was present . Negative_regulation IL12B STAT4 11739505 886522 A mandatory *role* for in [IL-12] induction of mouse T cell CCR5 . Negative_regulation IL12B STAT4 21813204 2495447 Exposure of splenocytes to AEBSF for 3h noticeably *inhibited* the induction of IFN? , IL-12 , and IL-12 induced , mRNA expression of T-bet and [IL-12Rß2] . Negative_regulation IL12B STAT4 8700208 372999 To determine the function of and its *role* in [IL-12] signalling , we have produced mice that lack Stat4 by gene targeting . Negative_regulation IL12B TLR7 15611251 1357322 We also show that ES-62 *inhibits* [IL-12] induction by ligands other than LPS , bacterial lipopeptide ( TLR2 ) and CpG ( TLR9 ) , via this TLR4 dependent pathway . Negative_regulation IL12B TLR7 17918201 1819350 In this study , we investigated which mouse B cell subsets are the most potent cytokine producers , and examined the *role* of in the control of secretion of IL-6 , IL-10 , [IL-12] and IFN-gamma by B cells . Negative_regulation IL12B TLR7 18271077 1865810 Stimulation with TLR2 , TLR4 and ligands , as well as TLR3 ligand , *resulted* in significantly lower production of TNF-alpha , but neither IL-6 nor [IL-12p70] , by DCs from XLA patients in comparison to normal controls . Negative_regulation IL12B TLR7 19265172 2045532 expression was also *necessary* for the IFN-beta1a induced inhibition of IL-1beta and [IL-23] and the induction of IL-27 secretion by DCs . Negative_regulation IL12B TLR7 20112371 2219497 Sigirr-deficient dendritic cells expressed higher TLR7 mRNA levels and activation *resulted* in increased [IL-12] production in vitro . Negative_regulation IL12B TLR7 20498209 2289131 Remarkably , the production of [IL-12] was lower upon *stimulation* with ligands in most patients with SSc , whereas the secretion of IL-10 was very high in patients with the dSSc phenotype , particularly in those having early dSSc . Negative_regulation IL12B TLR7 20570038 2290410 The effect on IL-1beta , [IL-23] and IL-27 production in DCs was *mediated* by the up-regulation of and its downstream signaling molecules . Negative_regulation IL12B TLR7 22536449 2590097 Here , we examine the *role* of and reactive oxygen species ( ROS ) in [IL-12] production by LAB stimulated peritoneal macrophages . Negative_regulation IL12B TLR7 22685319 2675993 Interestingly , despite expression of TLR mRNA on Kupffer cells , ligation of TLR4 , , and TLR9 *resulted* in a weak induction of IL-10 , low or undetectable levels of [IL-12p40] and TNF , and up-regulation of CD40 on the surface . Negative_regulation IL12B TLR7 22753939 2627286 We demonstrate that concurrent Notch and stimulation results in a unique cytokine profile in mouse bone-marrow derived DCs characterized by enhanced IL-10 and IL-2 , and *reduced* [IL-12] expression compared with TLR ligation alone . Negative_regulation IL12B TNF 10626665 658962 [IL-12] secretion by microglia is significantly *reduced* by and IFN-gamma antagonists showing that the IL-12 production is subject to regulation by auto- and paracrine stimuli . Negative_regulation IL12B TNF 10657616 664056 IL-10 is not responsible for the mediated *inhibition* of [IL-12] . Negative_regulation IL12B TNF 12377934 997045 Inhibition of [IL-12] by FcgammaR cross linking was not *mediated* by , as the presence of an anti-TNF-alpha Ab could not restore the reduced IL-12 production . Negative_regulation IL12B TNF 21545584 2435329 treatment *induced* a decrease in TNF-a , [IL-12p40] and IL-10 mRNA levels in peritoneal cells following PPD stimulation while live M. tuberculosis caused an increase in TNF-a mRNA and a decrease in the IL-10 mRNA expression . Negative_regulation IL12B TNF 21764089 2599154 The findings suggested that CSFV infection significantly increased the mRNA expression of IL-10 and , and *inhibited* [IL-12] expression , with little effect on IFN-a and IFN-? expression . Negative_regulation IL12B TNF 21830095 2495576 Tacrolimus completely inhibited IFN-? and production of activated T-cells in LPMCs , but only partially *inhibited* IFN-? , TNF-a , and [IL-12] production of activated monocytes/macrophages in LPMCs . Negative_regulation IL12B TNF 22798676 2639933 PLC activation enhanced the bactericidal activity and hydrogen peroxide production of mouse neutrophils , and it also *enhanced* the production of IFN-? and [IL-12] while inhibiting proseptic and IL-1ß production in cecal ligation and puncture mice . Negative_regulation IL12B TNF 22923002 2726419 Interestingly , , but not CGS21680 , dramatically *inhibited* [IL-12] mRNA expression . Negative_regulation IL12B TNF 23508772 2756970 This article will provide a summary of the cumulative pediatric safety and efficacy data for the anti-tumor necrosis factor-alpha ( ) agents and [interleukin (IL)-12] and IL-23 ( IL12/23 ) pathway *inhibitor* and suggestions for a rational clinical approach to their use in children with psoriasis . Negative_regulation IL12B TNF 8833901 386013 [IL-12] production is preceded by TNF-alpha production and is *inhibited* by recombinant soluble human receptor ( II ) -IgG1 fusion protein ( shu-TNF-R ) . Negative_regulation IL12B TNF 9394829 468227 We found that exogenously added *caused* a profound inhibition of monocytic [IL-12] secretion in the absence of IC , again mediated via the induction of IL-10 and PG . Negative_regulation IL12B TNF 9811882 545921 To determine whether *inhibition* of IFN-gamma induced [IL-12] production contributed to the resolution of an inflammatory response in vivo , the response of TNF+/+ and TNF-/- mice injected with Corynebacterium parvum were compared . Negative_regulation IL12B TP63 24047617 2888225 [IL12/23] *inhibition* ameliorates Alzheimer 's disease associated neuropathology and spatial memory in SAMP8 mice . Negative_regulation IL13 CST6 23174104 2740856 Ex vivo restimulation with cystatin of spleen cells from cystatin treated mice induced the production of IL-10 , while *inhibited* allergen-specific IL-5 and [IL-13] levels . Negative_regulation IL13 KLF9 14976188 1236115 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL13 TLR7 20677943 2305500 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL13 TNF 8833901 385997 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL13 TNF 8957229 401620 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL13 TNF 9162077 431915 Whereas LPS induced production is strongly suppressed by both cytokines , TNF-alpha mRNA accumulation is not significantly affected , indicating that IL-4 and [IL-13] *induce* a translational repression of TNF-alpha mRNA . Negative_regulation IL15 IL1B 14967219 1209135 However , using ELISA and Northern blot analyses we found that significantly *inhibited* P-induced [IL-15] production and mRNA expression in long-term culture ( for 12 days ) of ESCs in vitro ( P < 0.01 ) . Negative_regulation IL15 KLF9 14976188 1236132 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL15 MYH16 12372339 996328 Overexpression of [IL-15] *induced* fivefold higher levels of sarcomeric and alpha-actin accumulation in differentiated myotubes . Negative_regulation IL15 MYH3 12372339 996335 Overexpression of [IL-15] *induced* fivefold higher levels of sarcomeric and alpha-actin accumulation in differentiated myotubes . Negative_regulation IL15 TLR7 20677943 2305510 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL15 TNF 21794570 2185292 Our data seem to support previous in vitro findings suggesting that is *involved* in the regulation of [IL-15] expression . Negative_regulation IL15 TNF 8833901 385998 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL15 TNF 8957229 401621 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL16 KLF9 14976188 1236149 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL16 TLR7 20677943 2305520 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL16 TNF 8833901 385999 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL16 TNF 8957229 401622 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL17A ARSA 23306703 2725939 *inhibited* the production of [interleukin (IL)-17] from lung T cells as well as in vitro Th17 polarization induced by IL-6 . Negative_regulation IL17A IL1B 11777983 899880 Furthermore , IL-17 , , and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs , and specific MAPK inhibitors ( SB203580 , PD98059 , and U0216 ) significantly *reduced* [IL-17-] , IL-1beta- , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Negative_regulation IL17A RAB31 15972674 1424197 The activities of both [IL-17A] and IL-17F were *blocked* by a specific , but only IL-17A was blocked with a soluble IL-17R , suggesting that cell membrane IL-17R is required for signaling by both IL-17A and IL-17F . Negative_regulation IL17A RORC 22326581 2560643 Th17 cells also exhibited *dependent* CD28 hyperexpression and the ability to produce [IL-17A] after CD28 stimulation without CD3 triggering . Negative_regulation IL17A TNF 11777983 899879 Furthermore , IL-17 , IL-1beta , and induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs , and specific MAPK inhibitors ( SB203580 , PD98059 , and U0216 ) significantly *reduced* [IL-17-] , IL-1beta- , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Negative_regulation IL17A TNF 22582749 2614283 and antiseptic therapies prevented the development and exacerbation of infectious-PD. Anti-TNF-a therapy also *resulted* in reduced expression of IFN-? , TNF-a and [IL-17] in maxillae . Negative_regulation IL17D TLR7 20570038 2290411 The effect on IL-1beta , IL-23 and [IL-27] production in DCs was *mediated* by the up-regulation of and its downstream signaling molecules . Negative_regulation IL17F EPHB2 20061405 2205487 In this study , we report that pharmacologic inhibition of signaling enhances the in vitro differentiation of Th17 cells and *increases* their gene expression of il-17a , [il-17f] , il-21 , il-22 , and il-23r . Negative_regulation IL17F MAP2K6 20061405 2205493 In this study , we report that pharmacologic inhibition of signaling enhances the in vitro differentiation of Th17 cells and *increases* their gene expression of il-17a , [il-17f] , il-21 , il-22 , and il-23r . Negative_regulation IL17F RAB31 15972674 1424170 The activities of both IL-17A and [IL-17F] were *blocked* by a specific , but only IL-17A was blocked with a soluble IL-17R , suggesting that cell membrane IL-17R is required for signaling by both IL-17A and IL-17F . Negative_regulation IL17RD EPHB2 21663947 2459723 We found that the [hSef] expression was positively regulated by FGF2 induced MAPK/ERK signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation IL18 ADRB2 15998544 1459202 stimulation *inhibits* LPS induced [IL-18] and IL-12 production in monocytes . Negative_regulation IL18 KLF9 14976188 1236166 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL18 TLR7 20677943 2305530 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL18 TNF 11125306 762814 *mediated* a large decrease in [IL-18] mRNA levels in the human keratinocyte cell line HaCaT , which was accompanied by a subsequent accumulation of IL-18 protein in the cell culture supernatants , which was shown to be biologically active . Negative_regulation IL18 TNF 8833901 386000 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL18 TNF 8957229 401623 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL18 TNF 9449707 483969 [IL-18] did not *induce* antiinflammatory cytokines , IL-1Ra , or IL-10 , although IL-18 induction of was inhibited by IL-10 . Negative_regulation IL19 KLF9 14976188 1236183 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL19 TLR7 20677943 2305540 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL19 TNF 8833901 386001 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL19 TNF 8957229 401624 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL1A ALOX5 8722494 373708 Leukotriene B4 ( 1-100 ng/mL-1 ) added to MK-886 ( 5 microM ) -treated cultures reversed the inhibitory effects of the latter on IL-1 , confirming the *role* of <5-lipoxygenase> products in the regulation of [IL-1] production . Negative_regulation IL1A CD14 15760549 1383243 Glycine could efficiently protect rat liver grafts from ischemia-reperfusion injury by repressing the expression of and NF-kappa B binding activity in Kupffer cells and *inhibiting* the productions of TNF alpha and [IL-1] . Negative_regulation IL1A CD14 20946675 2337960 Blocking in monocytes inhibited secretion of interleukin (IL)-1ß ( 72 % ) , IL-6 ( 58 % ) and IL-10 ( 63 % ) , and blocking TLR4 *inhibited* secretion of [IL-1ß] by 67 % , IL-6 by 63 % and IL-10 by 60 % . Negative_regulation IL1A EPHB2 23680829 2819350 These results suggest that [IL-1] *induces* an imbalance between anabolic and catabolic events in AF cells , inhibition could provide some protection against the adverse effects of IL-1 . Negative_regulation IL1A EPHB2 23973554 2873381 The TCI induced activation of astrocytes and microglial cells , as well as the increased levels of [IL-1ß] and TNF-a , were *inhibited* by intrathecal administration of TLR4 targeting siRNA2 and the EphB receptor antagonist , respectively . Negative_regulation IL1A IL1B 11723165 884124 At the protein level , IL-4 and IL-10 dramatically reverse the ability of to *inhibit* expression of [IL-1RI] but neither affects the ability of IL-1 beta to enhance the number of IL-1RII . Negative_regulation IL1A IL1B 1533322 186465 Excess unlabeled or IL-1ra *blocked* the binding of 125I-IL-1 beta to the [IL-1RtII] . Negative_regulation IL1A IL1B 1715791 165016 In this study , we investigated the *role* of in the malignant evolution of chronic myelogenous leukemia ( CML ) and the functional activity of [IL-1] inhibitors . Negative_regulation IL1A IL1B 18573490 1935043 Furthermore , LYR-71 down-regulated LPS induced transcription of [interleukin (IL)-1beta] or other cytokines in the cells , and *inhibited* expression vector IKKbeta elicited promoter activity . Negative_regulation IL1A IL1B 2141815 135728 In competition studies , IL-1 alpha , IL-1 beta , and a weak IL-1 beta analog *inhibited* [ 125I ] [IL-1 alpha] binding to mouse testis in parallel with their relative bioactivities in immune assays , with inhibitory binding affinity constant ( Ki ) values of 14.2 +/- 1.7 , 88.8 +/- 5.7 , and 7183.3 +/- 603 pM , respectively ; Negative_regulation IL1A IL1B 2438338 72985 This discrepancy with the bioassay used was reflected by the three fold higher maximum stimulation of thymocyte proliferation by HMCS as compared with recombinant IL 1 alpha or , and only 45 % *inhibition* of HMCS [IL 1] activity by McAb . Negative_regulation IL1A IL1B 2521349 105646 Binding of [125I-IL-1 alpha] to the mouse and human PMN is *inhibited* by both recombinant human IL-1 alpha and , indicating that both IL-1 proteins bind to the same receptor on these cells . Negative_regulation IL1A IL1B 2969918 95663 *inhibited* binding of [125I-IL-1 alpha] with a Ki of 2-3 pM ( n = 2 ) and binding of 125I-IL-1 beta with a Ki of 7 pM ( n = 2 ) . Negative_regulation IL1A IL1B 9531272 496775 Whereas *down-regulated* [IL-1RI] surface expression ( p < 0.05 ) , there was no change in the surface expression of IL-1RAcP . Negative_regulation IL1A IL1R2 21181432 2447469 Our results demonstrated that the rat heterodimer ( IC50=1.95 pM ) *inhibited* [IL-1] response to a greater extent than IL1RA ( IC50=1,935 pM ) , Acp-IL1R type I (IL1R1)-Ig homodimer ( IC50=73.7 pM ) and Acp-IL1R2-Ig homodimer ( IC50=72.8 pM ) . Negative_regulation IL1A IL1R2 21181432 2447473 The heterodimer , which is similar to the original extracellular structure of the Acp/IL1R1 complex , may *inhibit* the [IL-1] response more vigorously than other IL-1 blocking biopharmaceutical agents . Negative_regulation IL1A IL1R2 23999049 2851284 Importantly , the stimulatory effect of rgcIL-1ß on its own mRNA expression was blocked by rgcIL-1R2 in a dose dependent manner in grass carp HKLs , providing the evidence for a functional *role* of in [IL-1ß] signaling in teleost . Negative_regulation IL1A IL1R2 8332913 223645 These results , together with the effect of antibodies to IL-1R on IL-1 induced production of cytokines in monocytes , indicate that IL-1 acts on myelomonocytic cells through IL-1R I and that *inhibits* [IL-1] activity by acting as a decoy target for IL-1 . Negative_regulation IL1A S100B 19961838 2199379 Albumin activated ERK1/2 , p38 MAPK and JNK signaling pathways in astrocytes , and *induced* the production of [interleukin (IL)-1beta] , inducible nitric oxide (NO) synthase , the NO metabolite nitrite , and the chemokine CX3CL1 while reducing the level of . Negative_regulation IL1A TLR7 16538507 1574454 binding *results* in cell signal transduction and subsequent production of various proinflammatory cytokines such as [IL-1] and TNF-alpha . Negative_regulation IL1A TNF 10754457 682694 Inflammation was *induced* by , resulting in an increased [interleukin 1alpha (Il-1alpha)] synthesis . Negative_regulation IL1A TNF 11686517 875871 Moreover , we demonstrated that M. furfur modulates proinflammatory and immunomodulatory cytokine synthesis by downregulating [IL-1alpha] and by *inhibiting* IL-6 and and by upregulating IL-10 and TGF-beta1 . Negative_regulation IL1A TNF 1429677 202691 IL-10 not only suppressed release to a 25-fold greater extent than TGF-beta , but also *inhibited* release of [IL-1] . Negative_regulation IL1A TNF 16209246 1464389 Interleukin-1 receptor antagonist ( IL-1ra ) and soluble receptors ( sTNFR ) type I and II *reducing* the activity of [IL-1] and TNFalpha may inhibit inflammatory reactions . Negative_regulation IL1A TNF 19055838 2001744 release from LPS stimulated human peripheral blood mononuclear cells was inhibited with IC50s 16 +/- 6 nM and 14 +/- 8 nM , ( mean +/- S.D. ) for SB-203580 and VX-745 and [IL-1] was *inhibited* with IC50s of 20 +/- 8 nM and 15 +/- 4 nM ( mean +/- S.D. ) , respectively . Negative_regulation IL1A TNF 2001421 154491 *inhibits* [interleukin (IL)-1] and/or IL-6 stimulated synthesis of C-reactive protein (CRP) and serum amyloid A (SAA) in primary cultures of human hepatocytes . Negative_regulation IL1A TNF 22353423 2586869 In vitro , results based on cultured DRG neurons showed that siRNA mediated inhibition of NOV enhanced [IL-1ß-] and TNF-a induced MMP-2 , MMP-9 and CCL2 expression whereas NOV addition *inhibited* induced MMP-9 expression through ß1 integrin engagement . Negative_regulation IL1A TNF 22711073 2621313 Role of NLRP3 and CARD8 in the regulation of *induced* [IL-1ß] release in vascular smooth muscle cells . Negative_regulation IL1A TNF 23445729 2749240 We also found that high-dose IgG specifically and completely inhibited accelerated expression of KD-related cytokines such as G-CSF , IL-6 and [IL-1ß] by HCAEC in *response* to . Negative_regulation IL1A TNF 23494261 2853785 Propofol modulates acute AQP-4 expression by attenuating [IL-1ß] and TNF-a expression and *inhibiting* IL-1ß and induced AQP-4 expression . Negative_regulation IL1A TNF 2350350 135204 and IL-1 were additive in their effects on ferritin H expression , and [IL-1] induction of ferritin H was not *blocked* by anti-TNF antibodies . Negative_regulation IL1A TNF 24490798 2913635 Ilantide bound [IL-1RI] , inhibited the IL-1ß induced activation of NF-?B , and *inhibited* the secretion of in vitro . Negative_regulation IL1A TNF 24928389 2946779 With metabolic labeling based proteomics and pathway analysis , we found that [IL-1ß] significantly *increases* the TNF downstream protein expression in FLS even with complete absence of and/or blocking of the NF-?B pathway . Negative_regulation IL1A TNF 7600192 311507 LPS1 significantly increased LPS2 triggered monocyte secretion of [IL-1] , IL-6 , and PGE2 , but *inhibited* release . Negative_regulation IL1A TNF 7789332 313110 To this aim , rats were ovariectomized and treated for 2 weeks with either IL-1 receptor antagonist (IL-1ra) , an *inhibitor* of [IL-1] , or , an inhibitor of TNF . Negative_regulation IL1A TNF 8457602 215624 ( 50 ng/ml ) *increased* the number of [IL-1] receptors to 2930 +/- 590 . Negative_regulation IL1A TNF 8547644 346413 We have previously shown that VCAM-1 expression is *induced* on human umbilical vein EC ( HUVEC ) by both tumor necrosis factor alpha (TNF-alpha) and [interleukin-1 alpha (IL-1 alpha)] , whereas on human dermal microvascular EC ( HDMEC ) only results in VCAM-1 expression . Negative_regulation IL1A TNF 9103454 423282 In contrast granulocyte-macrophage-CSF and , to a greater extent , markedly *reduced* [IL-1] binding . Negative_regulation IL1A TNF 9329960 457494 To identify the specific cytokine ( s ) responsible for macrophage activation , culture supernatants from EBV infected T cells were cocultured with a monocytic cell line U937 for 24 h. Enhanced phagocytosis and secretion of TNF-alpha , IFN-gamma , and [IL-1alpha] by U937 cells were observed , and could be *inhibited* to a large extent by ( 70 % ) , less effectively by anti-IFN-gamma ( 31 % ) , but almost completely by the combination of anti-TNF-alpha and anti-IFN-gamma ( 85 % ) . Negative_regulation IL1A TNF 9541129 498041 The three drugs did not decrease IL-6 and IL-8 secretion by colonic biopsies , whereas they did *inhibit* [IL-1] and , to some degree , production . Negative_regulation IL1B ACAN 9645953 514926 Compressive force promotes sox9 , type II collagen and and *inhibits* [IL-1beta] expression resulting in chondrogenesis in mouse embryonic limb bud mesenchymal cells . Negative_regulation IL1B ADCY1 15949713 1421348 Since activator forskolin *prevents* the increase in NE-induced [IL-1beta] and IL-10 , the up-regulatory effect of NE on those cytokines appears to be mediated , at least in part , by inhibition of adenylate cyclase and reduction in intracellular cyclic AMP levels . Negative_regulation IL1B ADCY10 15949713 1421347 Since activator forskolin *prevents* the increase in NE-induced [IL-1beta] and IL-10 , the up-regulatory effect of NE on those cytokines appears to be mediated , at least in part , by inhibition of adenylate cyclase and reduction in intracellular cyclic AMP levels . Negative_regulation IL1B ADCY2 15949713 1421349 Since activator forskolin *prevents* the increase in NE-induced [IL-1beta] and IL-10 , the up-regulatory effect of NE on those cytokines appears to be mediated , at least in part , by inhibition of adenylate cyclase and reduction in intracellular cyclic AMP levels . Negative_regulation IL1B ADCY3 15949713 1421350 Since activator forskolin *prevents* the increase in NE-induced [IL-1beta] and IL-10 , the up-regulatory effect of NE on those cytokines appears to be mediated , at least in part , by inhibition of adenylate cyclase and reduction in intracellular cyclic AMP levels . Negative_regulation IL1B ADCY4 15949713 1421351 Since activator forskolin *prevents* the increase in NE-induced [IL-1beta] and IL-10 , the up-regulatory effect of NE on those cytokines appears to be mediated , at least in part , by inhibition of adenylate cyclase and reduction in intracellular cyclic AMP levels . Negative_regulation IL1B ADCY5 15949713 1421352 Since activator forskolin *prevents* the increase in NE-induced [IL-1beta] and IL-10 , the up-regulatory effect of NE on those cytokines appears to be mediated , at least in part , by inhibition of adenylate cyclase and reduction in intracellular cyclic AMP levels . Negative_regulation IL1B ADCY6 15949713 1421353 Since activator forskolin *prevents* the increase in NE-induced [IL-1beta] and IL-10 , the up-regulatory effect of NE on those cytokines appears to be mediated , at least in part , by inhibition of adenylate cyclase and reduction in intracellular cyclic AMP levels . Negative_regulation IL1B ADCY7 15949713 1421354 Since activator forskolin *prevents* the increase in NE-induced [IL-1beta] and IL-10 , the up-regulatory effect of NE on those cytokines appears to be mediated , at least in part , by inhibition of adenylate cyclase and reduction in intracellular cyclic AMP levels . Negative_regulation IL1B ADCY8 15949713 1421355 Since activator forskolin *prevents* the increase in NE-induced [IL-1beta] and IL-10 , the up-regulatory effect of NE on those cytokines appears to be mediated , at least in part , by inhibition of adenylate cyclase and reduction in intracellular cyclic AMP levels . Negative_regulation IL1B ADCY9 15949713 1421356 Since activator forskolin *prevents* the increase in NE-induced [IL-1beta] and IL-10 , the up-regulatory effect of NE on those cytokines appears to be mediated , at least in part , by inhibition of adenylate cyclase and reduction in intracellular cyclic AMP levels . Negative_regulation IL1B ADCYAP1 14579275 1156771 Furthermore , in LC and the XS106 cell line , *inhibited* the LPS/GM-CSF induced stimulation of [IL-1beta] secretion and augmented IL-10 production . Negative_regulation IL1B AHSA1 17395477 1728125 In the present study the quantitative *role* of p42/44 and in the production of TNF-alpha , [IL-1beta] and IL-12 by murine peritoneal macrophages , in vitro , on treatment with Concanavalin A ( ConA ) has been investigated . Negative_regulation IL1B AKAP5 2438338 72983 McAb H6 and are approximately 10-fold less potent , and completely *inhibit* [IL 1 beta] activity at 10 micrograms/ml ( 6 X 10 ( -8 ) M ) in both assays . Negative_regulation IL1B AKT1 20632386 2316674 Our results showed that GDNF resulted in a significant reduction in enhanced permeability , *inhibited* MPO activity , [IL-1beta] and TNF-alpha expression , and increased ZO-1 and expression . Negative_regulation IL1B AKT2 20632386 2316675 Our results showed that GDNF resulted in a significant reduction in enhanced permeability , *inhibited* MPO activity , [IL-1beta] and TNF-alpha expression , and increased ZO-1 and expression . Negative_regulation IL1B AKT3 20632386 2316676 Our results showed that GDNF resulted in a significant reduction in enhanced permeability , *inhibited* MPO activity , [IL-1beta] and TNF-alpha expression , and increased ZO-1 and expression . Negative_regulation IL1B APOA1 16574162 1562427 To investigate the mechanisms , we measured tumor necrosis factor alpha (TNF-alpha) , interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) levels in the serum and bronchoalveolar lavage (BAL) fluid and found that could significantly *inhibit* LPS induced increases in the [IL-1beta] and TNF-alpha levels in serum ( P < 0.05 , respectively ) , as well as in the IL-1beta , TNF-alpha , and IL-6 levels in BAL fluid ( P < 0.01 and P < 0.05 , P < 0.05 , respectively ) . Negative_regulation IL1B APOA1 18501625 1928139 We found that could attenuate LTA induced acute lung injury and inflammation and significantly *inhibit* LTA induced [IL-1beta] and TNF-alpha accumulation in the serum ( P < 0.01 and P < 0.05 , respectively ) , as well as in bronchoalveolar lavage (BAL) fluid ( P < 0.01 and P < 0.05 , respectively ) . Negative_regulation IL1B APOB 15662752 1350337 It became known , that oxidized can *inhibit* LPS induced binding of the NF-kappaB to DNA and the subsequent expression of TNF-alpha and [interleukin-1beta] in macrophages as well as oxidized LDL modulates activation of NF-kappaB in mononuclear phagocytes by altering the degradation of I-kappaBs . Negative_regulation IL1B APOB 1816321 177443 A non-receptor pathway was supported by two lines of evidence : 1 ) the inhibition could be reproduced with a lipid extract , and 2 ) oxidized also *inhibited* scavenger receptor negative THP-1 cell [IL-1 beta] mRNA expression . Negative_regulation IL1B APOB 8014577 262527 High Cu2+ to LDL ratios promoted extensive TBARS formation and these LDL were the most potent activators of IL-1 beta release , although with TBARS greater than 50 nmol/mg protein were cytotoxic and [IL-1 beta] release was *diminished* . Negative_regulation IL1B APOB 8690807 372652 Oxidized low density *inhibits* lipopolysaccharide induced binding of nuclear factor-kappaB to DNA and the subsequent expression of tumor necrosis factor-alpha and [interleukin-1beta] in macrophages . Negative_regulation IL1B AREG 17670913 1780542 The bioinformatic data were validated in experiments which showed that , but not epidermal growth factor , *results* in transcriptional up-regulation of IL-1alpha and [IL-1beta] . Negative_regulation IL1B ARSD 22963993 2673376 Subsequently , the *inhibited* the activation of glial cells and the expression of tumor necrosis factor (TNF)-a , [interleukin-1 beta] ( IL-1ß ) and cyclooxygenase-2 (COX-2) in rat brain . Negative_regulation IL1B ASIP 8228247 235724 Conversely , the IL-1 beta converting enzyme inhibitor , ( L-709,049 ) and the anti-inflammatory agent [ 5- ( 4-pyridyl ) 6 ( 4-fluorophenyl ) -2,3-dihydroimidazo ( 2,1-b ) thiazole ] ( SK & F 86002 ) *inhibited* [IL-1 beta] release in both the standard and staged release assays with IC50 of 1 microM . Negative_regulation IL1B ASIP 9050895 417097 Only z-VAD.FMK and reduced brain swelling , and N-benzyloxycarbonyl-Asp-Glu-Val-Asp-fluoromethylketone did not *attenuate* the ischemia induced increase in tissue [IL-1beta] levels . Negative_regulation IL1B ATG16L1 18849965 1988617 Loss of the autophagy protein *enhances* endotoxin induced [IL-1beta] production . Negative_regulation IL1B ATP8A2 7683610 216504 ) and concentration dependently *inhibited* the [interleukin-1 beta (IL-1 beta)] stimulated mesangial cell release of TXB2 at nanomolar doses ( IC50 = 50 ng . Negative_regulation IL1B BCL2 15818317 1393445 The authors investigated whether gene transfer of the human antiapoptotic protein by means of intratracheal adenoviral administration would preserve posttransplant lung function and *reduce* intragraft activated caspase activity and [IL-1beta] production in syngeneic rat donor lung grafts . Negative_regulation IL1B BGN 19605353 2123842 The objective of this study was to define the *role* of in the synthesis and activation of [IL-1beta] . Negative_regulation IL1B BIRC2 11373338 817855 In mesangial cells , [interleukin-1beta (IL-1beta)] and tumor necrosis factor-alpha *induced* cellular inhibitor of apoptosis 1 ( ) mRNA expression within 3 h . Negative_regulation IL1B BMP7 11786084 901236 *represses* the basal and TNF-alpha stimulated expression of the pro-inflammatory cytokines IL-6 and [IL-1beta] , the chemokines MCP-1 and IL-8 , and the vasoconstrictor ET-2 in PTEC . Negative_regulation IL1B BPI 8063410 268739 also *inhibited* LPS induced tumor necrosis factor alpha , [IL-1 beta] , and IL-6 release from human whole blood . Negative_regulation IL1B BSG 19509148 2098342 In addition , we provide evidence that suppression *results* in decreased [interleukin 1beta (IL-1beta)] , IL-6 , and IL-8 cytokine production , in vitro and in vivo . Negative_regulation IL1B C3 8617973 353951 In nonadherent PBMC , *suppressed* LPS induced synthesis of TNF-alpha ( 20-71 % decrease by 0.2-10 microgram/ml of C3a , p less than 0.01 ) and [IL-1 beta] ( 19-57 % decrease by 0.5-10 microgram/ml of C3a , p less than 0.01 ) , independently of endogenous production of PGE2 . Negative_regulation IL1B C3 8617973 353953 also *suppressed* LPS induced mRNA levels for TNF-alpha and [IL-1 beta] . Negative_regulation IL1B CA2 10857757 704520 We investigated the *role* of protein kinase C ( PKC ) and in the induction of PMN [IL-1beta] gene expression by GM-CSF . Negative_regulation IL1B CA2 12660148 1105967 We clarify an essential *role* for in ATP induced [IL-1beta] secretion and indicate an additional role of P2X7 receptors as enhancers of the secretory apparatus by which IL-1beta is released . Negative_regulation IL1B CALM3 10683464 669577 A kinase activator *reduced* the induction of [IL-1beta] in the serum of mice when administered with compound 506 , and protected the mice against the lethal toxicity . Negative_regulation IL1B CAPN1 7499244 332631 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Negative_regulation IL1B CAPN10 7499244 332632 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Negative_regulation IL1B CAPN11 7499244 332633 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Negative_regulation IL1B CAPN12 7499244 332630 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Negative_regulation IL1B CAPN13 7499244 332641 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Negative_regulation IL1B CAPN14 7499244 332642 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Negative_regulation IL1B CAPN15 7499244 332629 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Negative_regulation IL1B CAPN2 7499244 332634 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Negative_regulation IL1B CAPN3 7499244 332635 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Negative_regulation IL1B CAPN5 7499244 332636 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Negative_regulation IL1B CAPN6 7499244 332637 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Negative_regulation IL1B CAPN7 7499244 332638 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Negative_regulation IL1B CAPN8 7499244 332639 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Negative_regulation IL1B CAPN9 7499244 332640 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Negative_regulation IL1B CASP1 10448599 637121 The presence of IL-1Ra or antisense also *suppressed* the endogenous [IL-1 beta] production of AML cells , at both the level of pro-IL-1 beta and mature IL-1 beta . Negative_regulation IL1B CASP1 10578176 569563 In addition to the well established *role* of in the production of active [IL-1beta] and IL-18 in inflammation,4 an increasing number of reports has recently suggested that caspases may have a function outside of apoptosis . Negative_regulation IL1B CASP1 11051551 743437 ICEBERG is a novel protein that *inhibits* generation of [IL-1beta] by interacting with and preventing its association with RIP2 . Negative_regulation IL1B CASP1 12404229 1009764 In peripheral blood mononuclear cells , inhibition of *reduced* interleukin-1beta secretion , whereas blockade of phagocytosis inhibited calcium induced apoptosis and [interleukin-1beta] release . Negative_regulation IL1B CASP1 12794152 1098251 Fas induced monocyte cytokine responses were associated with monocyte apoptosis , nuclear translocation of NF-kappaB , and cytokine gene expression and were blocked by inhibition but not by *inhibition* of [IL-1beta] signaling . Negative_regulation IL1B CASP1 15294346 1283115 Production of macrophage [IL-1beta] was *inhibited* both at the levels of transcription and maturation by following inhalation exposure to isobutyl nitrite . Negative_regulation IL1B CASP1 1781424 175889 Probing the *role* of in [interleukin-1 beta] secretion . Negative_regulation IL1B CASP1 19853379 2165442 Using this model we observed that : ( 1 ) inflammasome components and products NALP1 , caspase-1 , IL-1beta and IL-18 were present in low levels in normal skin , but expression of all these was strongly up-regulated after fracture , ( 2 ) NALP1 , caspase-1 and IL-1beta were co-expressed in keratinocytes , and the number of NALP1 , caspase-1 , and IL-1beta positive cells dramatically increased at 4 weeks post-fracture , ( 3 ) LY303870 , an NK1 receptor antagonist , effectively blocked fracture induced up-regulation of activated inflammasome components and cytokines , ( 4 ) [IL-1beta] and IL-18 intraplantar injection *induced* mechanical allodynia in normal rats , and ( 5 ) both a selective inhibitor and an IL-1 receptor antagonist attenuated fracture induced hindpaw mechanical allodynia . Negative_regulation IL1B CASP10 12794152 1098252 Fas induced monocyte cytokine responses were associated with monocyte apoptosis , nuclear translocation of NF-kappaB , and cytokine gene expression and were blocked by inhibition but not by *inhibition* of [IL-1beta] signaling . Negative_regulation IL1B CASP12 12794152 1098262 Fas induced monocyte cytokine responses were associated with monocyte apoptosis , nuclear translocation of NF-kappaB , and cytokine gene expression and were blocked by inhibition but not by *inhibition* of [IL-1beta] signaling . Negative_regulation IL1B CASP14 12794152 1098253 Fas induced monocyte cytokine responses were associated with monocyte apoptosis , nuclear translocation of NF-kappaB , and cytokine gene expression and were blocked by inhibition but not by *inhibition* of [IL-1beta] signaling . Negative_regulation IL1B CASP16 12794152 1098263 Fas induced monocyte cytokine responses were associated with monocyte apoptosis , nuclear translocation of NF-kappaB , and cytokine gene expression and were blocked by inhibition but not by *inhibition* of [IL-1beta] signaling . Negative_regulation IL1B CASP2 12794152 1098254 Fas induced monocyte cytokine responses were associated with monocyte apoptosis , nuclear translocation of NF-kappaB , and cytokine gene expression and were blocked by inhibition but not by *inhibition* of [IL-1beta] signaling . Negative_regulation IL1B CASP3 12794152 1098255 Fas induced monocyte cytokine responses were associated with monocyte apoptosis , nuclear translocation of NF-kappaB , and cytokine gene expression and were blocked by inhibition but not by *inhibition* of [IL-1beta] signaling . Negative_regulation IL1B CASP3 15818317 1393449 In addition , AdvBcl-2 pretreatment led to diminished cytochrome c release into cytosolic extracts and reduced intragraft [IL-1beta] production and *inhibited* intragraft and caspase-9 activity . Negative_regulation IL1B CASP3 8912630 395411 IL-8 , but not [IL-1 beta] , was secreted from the anti-Fas stimulated RA synoviocytes even in the *presence* of inhibitor . Negative_regulation IL1B CASP4 12794152 1098256 Fas induced monocyte cytokine responses were associated with monocyte apoptosis , nuclear translocation of NF-kappaB , and cytokine gene expression and were blocked by inhibition but not by *inhibition* of [IL-1beta] signaling . Negative_regulation IL1B CASP5 12794152 1098257 Fas induced monocyte cytokine responses were associated with monocyte apoptosis , nuclear translocation of NF-kappaB , and cytokine gene expression and were blocked by inhibition but not by *inhibition* of [IL-1beta] signaling . Negative_regulation IL1B CASP6 12794152 1098258 Fas induced monocyte cytokine responses were associated with monocyte apoptosis , nuclear translocation of NF-kappaB , and cytokine gene expression and were blocked by inhibition but not by *inhibition* of [IL-1beta] signaling . Negative_regulation IL1B CASP7 12794152 1098259 Fas induced monocyte cytokine responses were associated with monocyte apoptosis , nuclear translocation of NF-kappaB , and cytokine gene expression and were blocked by inhibition but not by *inhibition* of [IL-1beta] signaling . Negative_regulation IL1B CASP8 12794152 1098260 Fas induced monocyte cytokine responses were associated with monocyte apoptosis , nuclear translocation of NF-kappaB , and cytokine gene expression and were blocked by inhibition but not by *inhibition* of [IL-1beta] signaling . Negative_regulation IL1B CASP9 12794152 1098261 Fas induced monocyte cytokine responses were associated with monocyte apoptosis , nuclear translocation of NF-kappaB , and cytokine gene expression and were blocked by inhibition but not by *inhibition* of [IL-1beta] signaling . Negative_regulation IL1B CASP9 15818317 1393450 In addition , AdvBcl-2 pretreatment led to diminished cytochrome c release into cytosolic extracts and reduced intragraft [IL-1beta] production and *inhibited* intragraft caspase-3 and activity . Negative_regulation IL1B CAT 16959029 1615760 Production of TNF-alpha and [IL-1beta] , measured after 24 hours of Abeta treatment , was also *prevented* by apocynin , and EUKs , but the early release ( measured after 1 hour of Abeta treatment ) of TNF-alpha was insensitive to apocynin or catalase . Negative_regulation IL1B CBS 20050288 2177398 We observed that *inhibited* the LPS induced release of [interleukin-1 beta] and tumor necrosis factor-alpha from microglia . Negative_regulation IL1B CCK 11819851 892890 significantly *inhibited* the LPS induced increase in serum TNF-alpha [IL-1beta] and IL-6 . Negative_regulation IL1B CCK 11973585 934300 compared with the control , LPS elevated the levels of TNF-alpha , IL-1 beta and IL-6 in serum and lung significantly , while significantly *inhibited* the LPS induced increases in TNF-alpha , [IL-1 beta] and IL-6 in serum and lung . Negative_regulation IL1B CCK 17505309 1744660 *inhibits* LPS induced [IL-1beta] production in pulmonary interstitial macrophages by modulating PKA , p38 , and NF-kappaB pathway . Negative_regulation IL1B CCK 17505309 1744667 In this study , we have examined the possible signaling pathways by which *inhibits* lipopolysaccharide (LPS) induced [IL-1beta] production in rat pulmonary interstitial macrophages . Negative_regulation IL1B CCL2 11274229 797578 These data suggested that ( 1 ) constitutive and [IL-1beta-inducible] expression of MCP-1 was differently regulated by AP-1 and NF-kappaB and ( 2 ) t-RA *inhibited* selectively the constitutive expression of via intervention in the AP-1 pathway . Negative_regulation IL1B CCL2 20712904 2317875 Resveratrol inhibited LPS induced expression and release of TNF-alpha , IL-6 , , and iNOS/NO in both cell types with more potency in microglia , and *inhibited* LPS induced expression of [IL-1beta] in microglia but not astrocytes . Negative_regulation IL1B CCL3 20223588 2243627 PSL induced [IL-1beta] up-regulation was *suppressed* by and siRNA against CCR1 and CCR5 . Negative_regulation IL1B CD14 23402023 2743573 Inhibiting complement and efficiently *reduced* the expression of the E. coli induced cytokines [IL-1beta] , IL-6 , IL-8 , and platelet derived growth factor bb . Negative_regulation IL1B CD14 9369942 464080 These observations suggest a functional *role* of endogenous in LPS stimulated expression of the [IL-1 beta] gene in the cells . Negative_regulation IL1B CD300A 16254138 1525685 In addition , cross linking of on the eosinophils in the presence of IL-5/GM-CSF inhibited the antiapoptotic effect of these cytokines and *blocked* the release of TNF-alpha , [IL-1beta] , IFN-gamma , IL-4 , and 3T3 fibroblast proliferation . Negative_regulation IL1B CD38 12718937 1030632 ligation by the F ( ab ' ) ( 2 ) IB4 mAb did not induce signals relevant for cytokine secretion and the block of the Fcgamma receptor I ( FcgammaRI ) by anti-CD64 or FcgammaRII by anti-CD32 mAb did not *inhibit* CD38 mediated [IL-1beta] release . Negative_regulation IL1B CD40LG 10950771 723453 ELISA and cytofluorometric analysis demonstrated that stimulation of HIV-1 infected macrophages *resulted* in substantial production of [IL-1beta] and IL-6 . Negative_regulation IL1B CD79A 8809146 383077 induced higher levels of IL-1Ra than Haemophilus influenzae type b ( Hib ) expressing lipopolysaccharide (LPS) , purified LPS or phorbol myristate acetate ( PMA ) , without induction of IL-1 beta release , and even *inhibited* LPS induced [IL-1 beta] release . Negative_regulation IL1B CEBPB 9590244 504778 Finally , we show that both cAMP and [IL-1beta] strongly *induce* steady-state levels of and C/EBPdelta mRNA levels . Negative_regulation IL1B CFTR 19247502 2040746 expression in HEK293 cells *suppresses* both basal and [IL1beta] induced IL-8 , and NFkappaB promoter activities as compared to the control cells transfected with empty vector ( p < 0.05 ) . Negative_regulation IL1B CHDH 15930749 1414595 Both and MCHD also potently reduced the mRNA levels of cyclooxygenase (COX)-2 , interferon (IFN)-gamma and IL-4 increased in oxazolone applied mouse ears , but weakly *inhibited* that of [IL-1beta] and TNF-alpha . Negative_regulation IL1B CISH 16303184 1502916 The studies demonstrated that <9-cis-RA> *inhibited* the production of nitric oxide ( NO ) as well as the pro-inflammatory cytokines TNF-alpha , [IL-1beta] and IL-12 p40 by LPS stimulated microglia . Negative_regulation IL1B CNP 15285999 1322161 Interestingly , markedly *reduced* bronchoalveolar lavage fluid [IL-1beta] levels . Negative_regulation IL1B CNTF 18214991 1895508 We show that *reduces* COX-2 levels , whereas IL-6 increases the expression of [IL-1beta] , TNFalpha , and Cox-2 . Negative_regulation IL1B COL2A1 9645953 514925 Compressive force promotes sox9 , and aggrecan and *inhibits* [IL-1beta] expression resulting in chondrogenesis in mouse embryonic limb bud mesenchymal cells . Negative_regulation IL1B COP 11432859 850291 *inhibits* caspase- 1-induced [IL-1beta] secretion as well as lipopolysaccharide induced IL-1beta secretion in transfected cells . Negative_regulation IL1B CPA1 16026998 1441663 In the cells activated by the protein kinase C specific phorbol ester ( phorbol 12-myristate 13-acetate ) and Ca ( 2+ ) ionophore ( A23187 ) both adenosine and the subtype-specific receptor agonists , ( A1 ) , CGS 21680 ( A2A ) and IB-MECA ( A3 ) *induced* a concentration dependent inhibition of [IL-1beta] release . Negative_regulation IL1B CPB1 19923057 2166981 *resulted* in increased TNF-alpha and [IL-1beta] production in the lung tissues . Negative_regulation IL1B CPB2 19923057 2166982 *resulted* in increased TNF-alpha and [IL-1beta] production in the lung tissues . Negative_regulation IL1B CPP 18771755 1975735 also *attenuated* the expression of inducible nitric oxide synthase and pro-inflammatory cytokines such as [IL-1beta] and TNF-alpha at mRNA levels . Negative_regulation IL1B CRAT 15612528 1348443 However , only SOD + and vitamin C *inhibited* the mRNA expression of [IL-1beta] . Negative_regulation IL1B CREBRF 16142635 1451384 The HE , the or nirtetralin also *inhibited* the increase of [IL1-beta] tissue levels induced by Cg . Negative_regulation IL1B CRH 12864977 1111788 Lack of attenuated LPS administration *induced* increase of [IL-1beta] mRNA expression in the spleen . Negative_regulation IL1B CRH 7588301 333846 In contrast , in combination with high doses of LPS ( 1 microgram/ml ) , *caused* inhibition of IL-1ra and [IL-1 beta] transcription and secretion . Negative_regulation IL1B CRK 15031635 1183838 CQ reduced [IL-1 beta] mRNA expression and strongly *inhibited* phosphorylation of mitogen activated protein kinase (MAPK) , and to a lesser extent c-Jun N-terminal kinase and extracellular signal regulated kinase 1/2 . Negative_regulation IL1B CRP 8568265 350979 Acute phase levels of enhance IL-1 beta and IL-1ra production by human blood monocytes but *inhibit* [IL-1 beta] and IL-1ra production by alveolar macrophages . Negative_regulation IL1B CSF1 2012180 156673 In addition , [IL-1 beta] and TNF-alpha *induced* high levels of granulocyte-macrophage colony stimulating factor ( GM-CSF ) and macrophage colony stimulating factor ( ) mRNAs . Negative_regulation IL1B CSF2 11446745 835420 [IL-1beta] up-regulation is not dependent on PKC but the PKC activator PMA *induces* low levels of production and acts synergistically with IL-1beta to further increase GM-CSF . Negative_regulation IL1B CSF2 1831680 165091 The production of IL-1ra and IL-1 beta are under differential regulation because serum , IgG , and were potent stimuli for the production of IL-1ra but not IL-1 beta , and the prevention of cell-cell contact of PBMC *reduced* IL-1ra but not [IL-1 beta] production . Negative_regulation IL1B CSF2 2012180 156674 In addition , [IL-1 beta] and TNF-alpha *induced* high levels of granulocyte-macrophage colony stimulating factor ( ) and macrophage colony stimulating factor ( M-CSF ) mRNAs . Negative_regulation IL1B CSF3 12115655 964249 In the *presence* of ( G-CSF ) , the release of [IL-1beta] and TNF-alpha by LPS stimulated human whole blood was suppressed . Negative_regulation IL1B CSF3 12115655 964250 *inhibited* [IL-1beta] release , but the formation of proIL-1beta was not attenuated , indicating that G-CSF interferes with the proteolytic processing of proIL-1beta . Negative_regulation IL1B CSF3 16141785 1451080 suppresses edema formation and *reduces* [interleukin-1beta] expression after cerebral ischemia in mice . Negative_regulation IL1B CTNNB1 12147254 970001 We investigated in this study the *role* of in the [IL-1beta] regulation of COX-2 expression in articular chondrocytes . Negative_regulation IL1B CXCL17 20609401 2304000 In a cellular model of inflammation , inhibited production of nitric oxide ( NO ) and prostaglandin E ( 2 ) ( PGE ( 2 ) ) and *attenuated* expression of tumor necrosis factor-alpha (TNF-alpha) , interleukin-6 (IL-6) , [IL-1 beta] , inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) . Negative_regulation IL1B CXCL9 18001276 1827068 Here we analysed cells positive for 5-bromo-2-deoxyuridine ( BrdU ; 50 mg/kg ) in animals in which cleavage of [IL-1beta] was *inhibited* by the caspase-1 inhibitor ( 10 pmol ) . Negative_regulation IL1B DCN 12853035 1109988 Cytokine measurements by ELISA showed that overexpression *reduced* TGF-beta and [IL-1beta] . Negative_regulation IL1B DDX58 18209072 1857816 In this study , we have studied the *role* of membrane associated TLRs and cytoplasmic receptors ( RLR ) in regulation of IFN-beta , IL-29 , [IL-1beta] , and IL-18 production and caspases 1 and 3 activation in human macrophages . Negative_regulation IL1B EDN1 20051644 2177411 The IL-1beta mRNA and protein levels were enhanced by stimulation in a dose dependent manner , and the enhancement of [IL-1beta] was *inhibited* by ETA or ETB receptor antagonists . Negative_regulation IL1B EDN1 20051644 2177413 These findings indicate that is *involved* in the regulation of [IL-1beta] expression in gingival tissues and suggest that ET-1 signaling to the cells may be a therapeutic target for treating IL-1beta dependent inflammatory responses . Negative_regulation IL1B EDNRA 20051644 2177412 The IL-1beta mRNA and protein levels were enhanced by ET-1 stimulation in a dose dependent manner , and the enhancement of [IL-1beta] was *inhibited* by or ETB receptor antagonists . Negative_regulation IL1B EDNRA 20514317 2270771 In addition , *suppressed* the expression of [IL-1beta] , COX-2 , and MMP-13 induced by UV irradiation . Negative_regulation IL1B EEF1E1 18327539 1919581 Antimicrobial peptide markedly *inhibited* the expression of inducible nitric oxide synthase (iNOS) , tumor necrosis factor-alpha (TNF-alpha) and [interleukin-1 beta (IL-1beta)] in lipopolysaccharide (LPS) stimulated RAW264.7 macrophage cells , whereas magainin 2 did not inhibit these activities . Negative_regulation IL1B EFNB2 19035475 1998593 EphB4 activation by significantly *inhibited* the expression of [IL-1beta] , IL-6 , matrix metalloproteinase 1 (MMP-1) , MMP-9 , MMP-13 , and RANKL , but not MMP-2 and osteoprotegerin . Negative_regulation IL1B EGF 15271652 1333115 We hypothesized that EGF stimulates the expression of the inducible NO synthase (iNOS) gene in the graft after SBT , followed by increased production of NO , resulting in the decrease of BT. Intestinal epithelial cells ( IEC ) -6 were treated with EGF and/or [IL-1beta] in the *presence* and absence of phosphatidylinositol 3-kinase ( PI3-kinase ) and receptor kinase inhibitors ( LY-294002 and tyrphostin A25 ) . Negative_regulation IL1B EGF 17670913 1780541 The bioinformatic data were validated in experiments which showed that amphiregulin , but not , *results* in transcriptional up-regulation of IL-1alpha and [IL-1beta] . Negative_regulation IL1B EGF 1940795 170617 Regulation of cytokine production in the human thymus : and transforming growth factor alpha *regulate* mRNA levels of interleukin 1 alpha (IL-1 alpha) , [IL-1 beta] , and IL-6 in human thymic epithelial cells at a post-transcriptional level . Negative_regulation IL1B ENTPD1 20201036 2248977 also *inhibited* [IL-1beta] release in vivo in the air pouch inflammatory model . Negative_regulation IL1B EPC1 10498857 647705 After a single intravenous injection ( i.v. ) , and at equivalent doses , both free MTX ( 500 microg ) and *inhibited* the LPS induced rise in plasma [IL-1beta] levels observed in MTX-PEG and saline treated rats . Negative_regulation IL1B EPC2 10498857 647706 After a single intravenous injection ( i.v. ) , and at equivalent doses , both free MTX ( 500 microg ) and *inhibited* the LPS induced rise in plasma [IL-1beta] levels observed in MTX-PEG and saline treated rats . Negative_regulation IL1B EPHB4 19035475 1998594 activation by ephrin B2 significantly *inhibited* the expression of [IL-1beta] , IL-6 , matrix metalloproteinase 1 (MMP-1) , MMP-9 , MMP-13 , and RANKL , but not MMP-2 and osteoprotegerin . Negative_regulation IL1B EPO 1712553 161234 A dose dependent decrease of up to 60 % in production was *induced* by [interleukin-1 beta] , interleukin-1 alpha , and tumor necrosis factor-alpha ( in that order of potency ) . Negative_regulation IL1B EPS15 19655406 2119144 In addition , ( 2.25 , 4.5 g/kg , ig 9 days ) *inhibited* the expression of TNF-alpha and [IL-1beta] and the biological activity of NF-kappaB . Negative_regulation IL1B EPS8 19655406 2119145 In addition , ( 2.25 , 4.5 g/kg , ig 9 days ) *inhibited* the expression of TNF-alpha and [IL-1beta] and the biological activity of NF-kappaB . Negative_regulation IL1B EPX 18842103 1981890 At a dose of 5000 U/kg , significantly *reduced* the increase in [IL-1beta] at 8 and 12 h in both cortical sides . Negative_regulation IL1B FCGR1A 12746896 1088807 Consistent with these effects on SF macrophages , also *inhibited* TNFalpha production , [interleukin-1beta] production , and cartilage degrading activity of RA synovial tissue explants . Negative_regulation IL1B FN1 8698481 372898 Furthermore , markedly *inhibited* the fimbria induced expression of [interleukin-1beta] and neutrophil-specific chemoattractant KC genes in macrophages . Negative_regulation IL1B FN1 8698481 372899 also *inhibited* the bacterial cell induced expression of [interleukin-1beta] and KC genes in the macrophages . Negative_regulation IL1B FUT4 8978306 408990 engagement by monoclonal antibody also *attenuated* [IL-1 beta] transcript degradation , demonstrating that signaling via CD15 also had posttranscriptional effects . Negative_regulation IL1B FXR1 19028791 2022893 activation by natural and synthetic ligands in these cell types *attenuated* [IL-1beta] , IL-6 , and TNF-alpha gene induction in response to Toll-like receptor 4 activation by LPS . Negative_regulation IL1B FXR2 19028791 2022894 activation by natural and synthetic ligands in these cell types *attenuated* [IL-1beta] , IL-6 , and TNF-alpha gene induction in response to Toll-like receptor 4 activation by LPS . Negative_regulation IL1B GAS6 18247125 1903453 Importantly , *suppressed* lipopolysaccharide induced expression of the inflammatory molecules [IL-1beta] and iNOS . Negative_regulation IL1B GCLC 12433058 1015655 Inhibition of , the rate limiting enzyme in the biosynthesis of GSH , by the action of L-buthionine- ( S , R ) -sulfoximine ( BSO ) , *potentiated* LPS induced [IL-1beta] , IL-6 and TNF-alpha production . Negative_regulation IL1B GDNF 20632386 2316677 Our results showed that resulted in a significant reduction in enhanced permeability , *inhibited* MPO activity , [IL-1beta] and TNF-alpha expression , and increased ZO-1 and Akt expression . Negative_regulation IL1B GDNF 9351662 461187 [Interleukin-1beta (IL-1beta)] and interferon-gamma (IFN-gamma) *induced* similar effects on production , whereas IL-2 and IL-6 had no significant effects . Negative_regulation IL1B GLA 19842026 2196502 significantly *inhibited* LPS induced protein expression of inducible nitric oxide synthase , [pro-interleukin-1beta] , and cyclooxygenase-2 as well as nitric oxide production and the intracellular glutathione level . Negative_regulation IL1B GP2 19214384 2050148 In addition , ZPDC ( 200 microg/ml ) not only diminished the production of superoxide anion , hydrogen peroxide , and nitric oxide , but also *suppressed* the expression of pro-inflammatory cytokines ( [IL-1 beta] , IL-6 , and TNF-alpha ) and proteins ( iNOS , COX-2 , and MMP-9 ) in LPS- stimulated RAW 264.7 cells . Negative_regulation IL1B GP2 20589743 2345425 We also found that MIL *reduced* the activity of COX-2 and expression of TNF-a and [IL-1 beta] in liver from CCl ( 4 ) -treated mice . Negative_regulation IL1B GP5 19214384 2050149 In addition , ZPDC ( 200 microg/ml ) not only diminished the production of superoxide anion , hydrogen peroxide , and nitric oxide , but also *suppressed* the expression of pro-inflammatory cytokines ( [IL-1 beta] , IL-6 , and TNF-alpha ) and proteins ( iNOS , COX-2 , and MMP-9 ) in LPS- stimulated RAW 264.7 cells . Negative_regulation IL1B GP5 20589743 2345426 We also found that MIL *reduced* the activity of COX-2 and expression of TNF-a and [IL-1 beta] in liver from CCl ( 4 ) -treated mice . Negative_regulation IL1B GP6 19214384 2050147 In addition , ZPDC ( 200 microg/ml ) not only diminished the production of superoxide anion , hydrogen peroxide , and nitric oxide , but also *suppressed* the expression of pro-inflammatory cytokines ( [IL-1 beta] , IL-6 , and TNF-alpha ) and proteins ( iNOS , COX-2 , and MMP-9 ) in LPS- stimulated RAW 264.7 cells . Negative_regulation IL1B GP6 20589743 2345424 We also found that MIL *reduced* the activity of COX-2 and expression of TNF-a and [IL-1 beta] in liver from CCl ( 4 ) -treated mice . Negative_regulation IL1B GP9 19214384 2050150 In addition , ZPDC ( 200 microg/ml ) not only diminished the production of superoxide anion , hydrogen peroxide , and nitric oxide , but also *suppressed* the expression of pro-inflammatory cytokines ( [IL-1 beta] , IL-6 , and TNF-alpha ) and proteins ( iNOS , COX-2 , and MMP-9 ) in LPS- stimulated RAW 264.7 cells . Negative_regulation IL1B GP9 20589743 2345427 We also found that MIL *reduced* the activity of COX-2 and expression of TNF-a and [IL-1 beta] in liver from CCl ( 4 ) -treated mice . Negative_regulation IL1B GPI 1443100 205110 In the absence of bicarbonate , or in the presence of 10 microM 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid , the of activated monocytes and the total protein synthesis did not change , but the production of [IL-1 beta] was *inhibited* . Negative_regulation IL1B GPI 19308263 2052251 Plasmodium falciparum ( pfGPI ) enhanced C5a receptor expression ( CD88 ) on monocytes , and the co-incubation of monocytes with C5a and pfGPI *resulted* in the synergistic induction of cytokines ( IL-6 , TNF , [IL-1beta] , and IL-10 ) , chemokines ( IL-8 , MCP-1 , MIP1alpha , MIP1beta ) and the anti-angiogenic factor sFlt-1 in a time and dose dependent manner . Negative_regulation IL1B GRAP2 12464556 1022201 Also for SB 202190 this correlation in inhibition of [IL-1beta] and TNFalpha synthesis ( IC ( 50 ) 's : 0.055 microM and 1.01 microM ) and kinase *inhibition* ( IC ( 50 ) : 0.088 microM ) could be shown . Negative_regulation IL1B GRAP2 17530716 1751474 Blocking of , but not ERK-1/2 , *resulted* in inhibition of both LPS mediated [IL-1beta] gene expression and the negative effects of LPS on matrix biosynthesis . Negative_regulation IL1B GRP 19145554 2048112 dose-dependently *inhibited* [IL-1beta] production from LPS treated RAW264.7 cells without altering cell viability . Negative_regulation IL1B GSTM1 11094861 755223 Thus , in this in vitro model of vasculitis , AF and *reduced* [IL-1 beta-] and TNF-alpha induced and PMN dependent HUVEC injury by interfering with intercellular signaling systems and cytotoxicity conferred by NO and PMN granula constituents . Negative_regulation IL1B GSTM2 11094861 755224 Thus , in this in vitro model of vasculitis , AF and *reduced* [IL-1 beta-] and TNF-alpha induced and PMN dependent HUVEC injury by interfering with intercellular signaling systems and cytotoxicity conferred by NO and PMN granula constituents . Negative_regulation IL1B GSTM3 11094861 755225 Thus , in this in vitro model of vasculitis , AF and *reduced* [IL-1 beta-] and TNF-alpha induced and PMN dependent HUVEC injury by interfering with intercellular signaling systems and cytotoxicity conferred by NO and PMN granula constituents . Negative_regulation IL1B GSTM4 11094861 755226 Thus , in this in vitro model of vasculitis , AF and *reduced* [IL-1 beta-] and TNF-alpha induced and PMN dependent HUVEC injury by interfering with intercellular signaling systems and cytotoxicity conferred by NO and PMN granula constituents . Negative_regulation IL1B GSTM5 11094861 755227 Thus , in this in vitro model of vasculitis , AF and *reduced* [IL-1 beta-] and TNF-alpha induced and PMN dependent HUVEC injury by interfering with intercellular signaling systems and cytotoxicity conferred by NO and PMN granula constituents . Negative_regulation IL1B GSTP1 18962899 2028841 Meanwhile , *prevented* LPS induced TNF-alpha , [IL-1beta] , MCP-1 and NO production . Negative_regulation IL1B HDAC1 19107653 2018855 Human articular chondrocyte cultures were treated with FGF2 or [IL-1beta] in the *presence* or absence of inhibitor ( trichostatin A , TSA ) . Negative_regulation IL1B HDAC2 19107653 2018856 Human articular chondrocyte cultures were treated with FGF2 or [IL-1beta] in the *presence* or absence of inhibitor ( trichostatin A , TSA ) . Negative_regulation IL1B HGF 20726333 2306936 In cocultures , [IL-1beta] *induced* HGF release , while CPT-11 alone or combined with IL-1beta decreased secretion . Negative_regulation IL1B HIF1A 16504308 1549057 Inhibition of degradation by proteasome inhibitor , MG-132 , *potentiated* hypoxia induced [IL-1beta] release from human astrocytes , and this response was blocked in the presence of CdCl2 . Negative_regulation IL1B HMGCR 18684863 1973541 inhibition *induces* [IL-1beta] release through Rac1/PI3K/PKB dependent caspase-1 activation . Negative_regulation IL1B HMGCR 18684863 1973551 Here we show that inhibition of by simvastatin treatment , mimicking MKD , *results* in increased [IL-1beta] secretion in a Rac1/PI3K dependent manner . Negative_regulation IL1B HMOX1 19885007 2161006 We examined our hypothesis whether inhibitory effects of aprotinin on cytokine induced inducible nitric oxide synthase (iNOS) expression ( [IL-1beta] plus TNF-alpha ) , reactive oxygen species ( ROS ) generation , and vascular smooth muscle cell ( VSMC ) proliferation were *due* to induction in rat VSMCs . Negative_regulation IL1B HMOX1 24038461 2857267 Increased expression partially reversed LPS-suppression of aggrecan and type II collagen gene expression and *suppressed* LPS induced gene expression of IL-6 , inducible nitric oxide synthase (iNOS) , matrix metalloproteinases ( MMPs ) , and [IL-1beta] . Negative_regulation IL1B HSF1 10328874 612958 As can function as both an activator of heat shock genes and a *repressor* of non-heat shock genes such as [IL1B] and c- fos , we have examined the potential role of HSF1 in the effects of NSAIDs on gene expression in a human monocytic cell line THP-1 . Negative_regulation IL1B HSF1 11801594 922384 Following our previous study , which demonstrated the transcriptional *repression* of the [IL-1beta] gene by ( Cahill , C. M. , Waterman , W. R. , Xie , Y. , Auron , P. E. , and Calderwood , S. K. ( 1996 ) J. Biol. Chem. 271 , 24874-24879 ) , we have examined the mechanisms of transcriptional repression . Negative_regulation IL1B HSF1 11801594 922385 Our studies show that *represses* the lipopolyliposaccharide induced transcription of the [IL-1beta] promoter through direct interaction with the nuclear factor of interleukin 6 ( NF-IL6 , also known as CCAAT enhancer binding protein ( C/EBPbeta ) , an essential regulator in IL-1beta transcription . Negative_regulation IL1B HSP90AA1 15077173 1265806 Short-time inhibition of *resulted* in impaired IKK kinase activation by TNFalpha , [IL-1beta] or phorbolester PMA . Negative_regulation IL1B HSP90AA1 17599753 1774577 The aim of this study was to investigate the *roles* of age and in insulin-like growth factor 1 (IGF-1) and [interleukin-1beta (IL-1beta)] signaling in chondrocytes . Negative_regulation IL1B HSPG2 17158358 1716897 In this study we investigated the *role* of phosphatidylcholine-specific phospholipase C ( ) in silica stimulated induction of TNF-alpha and [IL-1beta] and how PC-PLC activity is regulated by silica in a rat alveolar macrophage model . Negative_regulation IL1B ICAM1 17558352 1804564 Synergistic upregulation of [IL-1beta] production and neutrophil sequestration was *attenuated* by blocking by neutralizing antibody pretreatment . Negative_regulation IL1B ICAM1 9184651 436670 Both [IL-1 beta-] and TPA induced expression of ICAM-1 and increased neutrophil adhesion to HCEC were *inhibited* by the transcriptional inhibitor , actinomycin D ( AcD ; 1-10 micrograms/ml ) , and by an . Negative_regulation IL1B ICAM1 9712747 527383 In addition , clearly *inhibited* the fimbria induced expression of [IL-1beta] and TNF-alpha genes in the cells . Negative_regulation IL1B IDO1 12193539 981337 In contrast , COX2 mRNA is induced by IL-1beta at 6 , 9 , and 24 h . [IL-1beta] induction of IL mRNAs was in part significantly impaired in the *presence* of or NS-398 . Negative_regulation IL1B IFI44 17395477 1728126 In the present study the quantitative *role* of and p38 in the production of TNF-alpha , [IL-1beta] and IL-12 by murine peritoneal macrophages , in vitro , on treatment with Concanavalin A ( ConA ) has been investigated . Negative_regulation IL1B IFNB1 11444907 834154 In co-cultures of autologous T lymphocytes and monocytes stimulated by phytohaemagglutinin ( PHA ) , *inhibited* the production of TNF-alpha and [IL-1beta] by 88 and 98 % , respectively , whereas the simultaneous production of IL-1 receptor antagonist (IL-1Ra) , was enhanced two-fold . Negative_regulation IL1B IFNB1 11444907 834156 When monocytes were activated by plasma membranes of stimulated T cells , slightly *inhibited* the production of TNF-alpha and [IL-1beta] , while enhancing 1.5-fold that of IL-1Ra . Negative_regulation IL1B IFNB1 14698849 1195812 Furthermore , we recently demonstrated that *inhibits* the production of [IL-1beta] and tumor necrosis factor-alpha (TNF) in human monocytes activated by cellular contact with stimulated T cells , a mechanism which we suspected of playing an important part in the pathogenesis of chronic inflammatory diseases including MS . Negative_regulation IL1B IFNB1 14698849 1195820 *inhibited* the expression ( mRNA ) and production ( protein ) of [IL-1beta] and TNF , while enhancing those of IL-1Ra in monocytes activated by msHUT . Negative_regulation IL1B IFNB1 19265172 2045535 TLR7 expression was also necessary for the *induced* inhibition of [IL-1beta] and IL-23 and the induction of IL-27 secretion by DCs . Negative_regulation IL1B IFNB1 9459613 475708 not only *inhibits* [interleukin-1beta] and tumor necrosis factor-alpha but stimulates interleukin-1 receptor antagonist production in human peripheral blood mononuclear cells . Negative_regulation IL1B IFNB1 9537260 497522 However , IFN-alpha and *inhibited* [IL-1beta] or TNF-alpha mediated up-regulation of IL-8 mRNA . Negative_regulation IL1B IFNG 11441112 833436 In contrast , *inhibited* basal and [IL-1beta-] , and TNF-alpha induced production of IL-8 . Negative_regulation IL1B IFNG 11506742 848003 *inhibits* lipopolysaccharide induced [interleukin-1 beta] in primary murine macrophages via a Stat1 dependent pathway . Negative_regulation IL1B IFNG 15930749 1414596 Both CHD and MCHD also potently reduced the mRNA levels of cyclooxygenase (COX)-2 , and IL-4 increased in oxazolone applied mouse ears , but weakly *inhibited* that of [IL-1beta] and TNF-alpha . Negative_regulation IL1B IFNG 16844399 1625315 The worsening of sepsis and arthritis was associated with a significant *increase* in systemic and local production of IL-6 , [IL-1 beta] , TNF-alpha , IL-10 , macrophage inflammatory protein 1 alpha ( MIP-1alpha ) , and MIP-2 and with a decrease in production . Negative_regulation IL1B IFNG 18025126 1827594 The CCL20 production by synoviocytes is augmented in vitro by [IL-1beta] , IL-17 , or tumor necrosis factor alpha , and is *suppressed* by or IL-4 . Negative_regulation IL1B IFNG 19688220 2150901 The results indicated that : ( 1 ) circulating levels and constitutive production of [IL-1beta] by macrophages are deregulated in rats with MS , and ( 2 ) IL-1beta and production by macrophages in response to antigenic stimulus ( LPS ) is *impaired* in the obese animals , and this MS-associated disorder is improved by the program of habitual exercise training . Negative_regulation IL1B IFNG 20307272 2273079 *reduced* [IL-1beta] expression in the arthritic joint and prevented cartilage degeneration on Day 3 of AIA . Negative_regulation IL1B IFNG 2503278 115186 significantly *inhibited* the spontaneous intracellular [IL-1 beta] production in SFM phi 12-h cultures of RA patients . Negative_regulation IL1B IFNG 7575406 325046 However , nuclear run-on analysis revealed that LPS increased the transcription of the IL-8 and [IL-1 beta] genes and that , in LPS activated cells , markedly *inhibited* the rate of IL-8 gene transcription , but not that of IL-1 beta . Negative_regulation IL1B IFNG 7743669 306073 LPS , or TNF-alpha had no effect on spontaneous IL-6 production , and neither *resulted* in the secretion of [IL-1 beta] or TNF-alpha . Negative_regulation IL1B IFNG 9712071 527175 Like IFN-beta , *suppresses* the expression of both LPS and IL-1 induced [IL-1beta] . Negative_regulation IL1B IGF1 11571581 864326 Local gene transfer *attenuates* the mRNA expression of the inflammatory cytokines [IL-1beta] and TNF-alpha in the burn wound . Negative_regulation IL1B IGF1 18004231 1943904 *inhibited* increases in TNF-alpha , [IL-1 beta] , and cytokine induced neutrophil chemoattractant 1 caused by GalN/LPS in serum and liver and enhanced serum IL-10 . Negative_regulation IL1B IGF1 19834007 2164905 Stretch of CFs , rather than CMs , abundantly *induced* the generation of [IL-1beta] and IGF-1 , whereas such induction was markedly decreased in IL-1beta-deficient CFs . Negative_regulation IL1B IGKV1-27 19851077 2209552 expression *reduced* EPC activation by tumor necrosis factor-alpha and [interleukin-1beta] as determined from changes in vascular cell adhesion molecule 1 and E-selectin expression and decreased monocyte transmigration through a monolayer of EPCs . Negative_regulation IL1B IKBKB 15723090 1396076 Similarly , ( KA ) and I kappa B alpha delta N overexpression also *inhibited* [IL-1beta-] and TNF alpha dependent increases in ICAM-1 , IL-8 and GM-CSF in addition to IL-1beta mediated increases in cyclooxygenase-2 expression , whereas IKK alpha ( KM ) overexpression had little effect on these outputs . Negative_regulation IL1B IKBKB 17803913 1791082 Prolonged pharmacologic inhibition of also *augments* [IL-1beta] secretion upon endotoxin challenge . Negative_regulation IL1B IKBKG 18313693 1886033 This is sufficient to alter NEMO function , since functional complementation assays using NEMO-deficient pre-B and T lymphocytes show that full-length C417F pathogenic *leads* to a partial to strong defect in LPS , [IL-1beta] and TNF-alpha induced NF-kappaB activation , respectively , as compared to wild type NEMO . Negative_regulation IL1B IL10 10623445 658043 In contrast , [IL-1beta] and IL-6 production by Mbeta from young males was suppressed and IL-10 production *enhanced* following trauma-haemorrhage , whereas Mstraight phi from aged males produced elevated levels of IL-1beta and IL-6 and suppressed levels of following trauma-haemorrhage . Negative_regulation IL1B IL10 10651950 662563 also *inhibited* the production of [interleukin-1beta (IL-1beta)] and the expression of mRNA for IL-1beta , indicating that this cytokine has a broad anti-inflammatory effect . Negative_regulation IL1B IL10 10719355 676939 LPS induced levels of [IL-1beta] were *suppressed* by , but not by IL-4 and TGF-beta1/beta2 . Negative_regulation IL1B IL10 11180507 784981 These results indicate that in glia from WT mice , exogenous *attenuates* LPS-induces release of NO , PGE ( 2 ) , TNF-alpha and [IL-1beta] . Negative_regulation IL1B IL10 12010759 941264 also *suppressed* LPS induced [IL-1 beta] production in peripheral tissues and in the brain stem . Negative_regulation IL1B IL10 12111847 963560 The LPS induced secretion of IL-1beta and TNF-alpha was only reduced after application of ACM , whereas IL-4 or did not *inhibit* [IL-1beta-] or TNF-alpha secretion . Negative_regulation IL1B IL10 12202153 983031 *inhibited* LPS induced upregulation of costimulatory molecules , MHC Class II , and the secretion of IL-12 , TNF-alpha , IL-6 , and [IL-1beta] by DCs , although it upregulated the SLAM ( CD150 ) expression at both the mRNA and protein levels . Negative_regulation IL1B IL10 12370389 995960 Moreover , P. aeruginosa induced production of IL-1alpha and [IL-1beta] was *down-regulated* by and dexamethasone . Negative_regulation IL1B IL10 12444457 1017432 ELISA ( protein level ) and RNAse protection assay ( mRNA level ) showed that SGE *enhanced* interleukin (IL)-1alpha , [IL-1beta] , IL-1Ra , IL-6 , and IL-12p40 cytokines , whereas production of IL-2 , IL-5 , , and IL-13 was decreased . Negative_regulation IL1B IL10 12813366 1103125 The beneficial effects of may be *mediated* by the inhibition of [IL-1beta] and KC/GRO through an endocrine rather than paracrine signal . Negative_regulation IL1B IL10 1387585 196235 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL10 1429677 202688 Transforming growth factor (TGF)-beta and *inhibited* lipopolysaccharide (LPS) induced macrophage production of the inflammatory cytokines tumor necrosis factor-alpha (TNF) , IL-1 alpha , and [IL-1 beta] by contrasting post-transcriptional mechanisms . Negative_regulation IL1B IL10 1429677 202695 Unlike TGF-beta , markedly *suppressed* TNF , IL-1 alpha , and [IL-1 beta] mRNA levels . Negative_regulation IL1B IL10 15293233 1278951 Results from these studies demonstrated a consistent *mediated* suppression of TNF-alpha ( 60 % +/- 2 % ) , [IL-1beta] ( 68 % +/- 3 % ) , CCL5 ( 62 +/- 4 % ) , but not CXCL10 production by HSV-1 infected microglial cells . Negative_regulation IL1B IL10 15527169 1329591 In contrast , IL-4 and *inhibit* LPS or [IL-1beta] induced pro-inflammatory cytokine production . Negative_regulation IL1B IL10 15826869 1403877 In contrast to living bacteria , it had no effect on the [IL-1beta] release , but it *induced* secretion . Negative_regulation IL1B IL10 15949713 1421346 The results indicate that serum levels of IL-1beta and *increased* significantly after the intraportal infusion of NE. Co-administration of NE and YHB , however , significantly attenuated [IL-1beta] and IL-10 production . Negative_regulation IL1B IL10 17184847 1695284 *reduces* hyperalgesia and the level of [Interleukin-1beta] in BALB/c mice infected with Leishmania major with no major effect on the level of Interleukin-6 . Negative_regulation IL1B IL10 17805009 1791261 The secretion of tumor necrosis factor-alpha (TNF-alpha) and [IL-1beta] elicited by UCB in astrocytes was reduced in the *presence* of GUDCA and , whereas the suppression of IL-6 was only counteracted by GUDCA . Negative_regulation IL1B IL10 19026560 2001523 The MMP-13 and [IL-1beta] expression by TNF-alpha was slightly *reduced* by . Negative_regulation IL1B IL10 19232107 2040088 Primary cultures of murine macrophage and ovalbumin ( OVA ) specific T cells showed that whole mushroom extracts alone had no effect on cytokine production but co-stimulation with either lipopolysaccharide or OVA ( respectively ) *induced* TNF-alpha , IFN-gamma , and [IL-1beta] while decreasing . Negative_regulation IL1B IL10 1940799 170631 Furthermore we demonstrate here that , added to monocytes , activated by interferon gamma (IFN-gamma) , LPS , or combinations of LPS and IFN-gamma at the onset of the cultures , strongly *inhibited* the production of IL-1 alpha , [IL-1 beta] , IL-6 , IL-8 , TNF alpha , GM-CSF , and G-CSF at the transcriptional level . Negative_regulation IL1B IL10 1940799 170637 Activation of monocytes by LPS in the presence of neutralizing anti-IL-10 monoclonal antibodies resulted in the production of higher amounts of cytokines relative to LPS treatment alone , indicating that endogenously produced *inhibited* the production of IL-1 alpha , [IL-1 beta] , IL-6 , IL-8 , TNF alpha , GM-CSF , and G-CSF . Negative_regulation IL1B IL10 20159741 2208561 Tylosin at 500 mg/kg had no effect on TNFalpha or [IL1beta] production , but it *induced* production in healthy mice . Negative_regulation IL1B IL10 20456417 2288478 In the presence of LPS , LcS enhanced [IL-1beta] production but *inhibited* LPS induced and IL-6 production , and had no further effect on TNF-alpha and IL-12 production . Negative_regulation IL1B IL10 7604878 311719 Whereas recombinant *inhibited* the generation of tumor necrosis factor-alpha (TNF-alpha) and [IL-1 beta] by 90 and 60 % , respectively , it did not affect the formation of nitric oxide derived nitrite ( NO2- ) and nitrate ( NO3- ) . Negative_regulation IL1B IL10 7721885 301693 Our previous studies in human monocytes have demonstrated that *inhibits* lipopolysaccharide (LPS) stimulated production of inflammatory cytokines , [IL-1 beta] , IL-6 , IL-8 , and tumor necrosis factor (TNF)-alpha by blocking gene transcription . Negative_regulation IL1B IL10 7790026 313159 and IL-4 *suppressed* equally [IL-1 beta] production by the same cells . Negative_regulation IL1B IL10 7822808 293073 had no significant effect on IL-1Ra production and *suppressed* [IL-1 beta] production ( primarily in samples producing high levels of IL-1 beta ) . Negative_regulation IL1B IL10 7852846 294754 IL-4 , , and IL-13 *suppressed* the generation of antitumor activity and cytokine production ( [IL-1 beta] and TNF-alpha ) of monocytes stimulated with MCAF plus norMDP or LPS . Negative_regulation IL1B IL10 8228247 235722 We find that dexamethasone or , when added together with 100 ng/ml LPS , *inhibits* [IL-1 beta] production with IC50 levels of 0.2 microM and 2.0 ng/ml , respectively . Negative_regulation IL1B IL10 8245792 236941 As shown by Northern blot analysis , *diminished* the levels of TNF , [IL-1 beta] , and IL-8 mRNAs late after the onset of stimulation of PMN with LPS . Negative_regulation IL1B IL10 8426121 211067 and ( b ) inhibition of the delayed production of , an *inhibitor* of TNF-alpha and [IL-1 beta] synthesis . Negative_regulation IL1B IL10 8568303 349835 significantly *inhibited* TNF-alpha , [IL-1 beta] , and IL-6 production by M. avium infected monocytes . Negative_regulation IL1B IL10 8646564 343021 *inhibits* lipopolysaccharide induced tumor necrosis factor and [interleukin-1 beta] production in the brain without affecting the activation of the hypothalamus-pituitary-adrenal axis . Negative_regulation IL1B IL10 9067646 418634 Taken together , these are the first studies that demonstrate that the depletion of endogenous via anti-IL-10 antibody results in a very significantly *enhanced* BCG induced [IL-1 beta] secretion and that the addition of exogenous IL-10 to human mononuclear cells stimulated with BCG inhibits IL-1 beta production . Negative_regulation IL1B IL10 9284853 451867 Recombinant human significantly *suppressed* production of the proinflammatory cytokines [interleukin-1 beta] and tumor necrosis factor-alpha by whole blood stimulated ex vivo with Escherichia coli lipopolysaccharide . Negative_regulation IL1B IL10 9435641 474751 and 3 ) inhibition of TNF and enhancement of both *contributed* to epinephrine induced inhibition of [IL-1 beta] production . Negative_regulation IL1B IL10 9753488 534001 plus corticosteroids additively *inhibited* [IL-1beta] secretion in human PBMNCs but preserved the beneficial IL-1RA/IL-1beta ratio induced by IL-10 . Negative_regulation IL1B IL10 9834343 479668 *reduced* the serum levels of [interleukin-1beta] , interleukin-6 , tumor necrosis factor-alpha , and amylase in comparison to untreated animals with pancreatitis ( P < 0.05 ) . Negative_regulation IL1B IL10 9870074 556734 Both and IL-4 *inhibited* [IL-1 beta-] and TNF-alpha induced PGE2 production but had no significant effects on the production of PGE2 under basal conditions . Negative_regulation IL1B IL11 1387585 196236 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL12A 7594594 325893 Furthermore , stimulation of SCID mouse splenocytes with , in the presence of anti-IFN-gamma , *resulted* in an increase in detectable levels of [IL-1 beta] . Negative_regulation IL1B IL12B 7594594 325894 Furthermore , stimulation of SCID mouse splenocytes with , in the presence of anti-IFN-gamma , *resulted* in an increase in detectable levels of [IL-1 beta] . Negative_regulation IL1B IL13 11399514 824221 In murine peritoneal macrophages , administered 2 hours before stimulation with LPS , *inhibited* the production of [IL-1 beta] ( - 67 % ) and PGE ( 2 ) ( - 56 % ) . Negative_regulation IL1B IL13 12444457 1017433 ELISA ( protein level ) and RNAse protection assay ( mRNA level ) showed that SGE *enhanced* interleukin (IL)-1alpha , [IL-1beta] , IL-1Ra , IL-6 , and IL-12p40 cytokines , whereas production of IL-2 , IL-5 , IL-10 , and was decreased . Negative_regulation IL1B IL13 1387585 196237 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL13 7533678 296869 In contrast , *inhibited* LPS induced [IL-1 beta] production by all cells , and as a positive response to IL-13 , CD23 expression was increased on both cell populations . Negative_regulation IL1B IL13 7852846 294755 IL-4 , IL-10 , and *suppressed* the generation of antitumor activity and cytokine production ( [IL-1 beta] and TNF-alpha ) of monocytes stimulated with MCAF plus norMDP or LPS . Negative_regulation IL1B IL13 8605347 352439 Accordingly , *suppressed* [IL-1beta] synthesis but enhanced IL-1Ra synthesis in these cells . Negative_regulation IL1B IL13 8605347 352441 Moreover , induced transcriptional activation of the IL-1Ra gene , but *reduced* [IL-1beta] gene transcription . Negative_regulation IL1B IL13 8843860 387444 Recombinant significantly *reduced* the production of [IL-1 beta] and tumor necrosis factor alpha and the expression of CD16 and CD64 by SF macrophages , whereas the expression of HLA-DR and CD23 was increased . Negative_regulation IL1B IL15 1387585 196238 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL16 1387585 196239 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL17A 11588011 866559 Moreover , overexpression of in the pulmonary compartment using a recombinant adenovirus encoding murine IL-17 ( AdIL-17 ) *resulted* in the local induction of tumor necrosis factor-alpha , [IL-1beta] , macrophage inflammatory protein-2 , and granulocyte colony stimulating factor ( G-CSF ) ; Negative_regulation IL1B IL17A 11777983 899882 Furthermore , , IL-1beta , and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs , and specific MAPK inhibitors ( SB203580 , PD98059 , and U0216 ) significantly *reduced* IL-17- , [IL-1beta-] , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Negative_regulation IL1B IL17A 19815670 2164499 IL-17A protein was detected in approximately 40 % of the supernatants and blockade , in IL-17A producing cultures , *resulted* in a small but significant inhibition of TNF-alpha ( 38 % ) , [IL-1beta] ( 23 % ) and IL-6 ( 22 % ) . Negative_regulation IL1B IL18 11570642 864279 *Role* of in the secretion of [Il-1beta] , sIL-1RII , and IL-1Ra by human neutrophils . Negative_regulation IL1B IL18 1387585 196240 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL19 1387585 196241 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL1A 1535356 190925 Competitive receptor binding studies demonstrated that unlabeled recombinant bovine IL-1 beta , murine , and human IL-1 beta competitively *blocked* neutrophil binding of 125I labeled bovine [IL-1 beta] . Negative_regulation IL1B IL1A 16171241 1457202 Furthermore , we investigated the effects of unilateral application of an [IL-1beta] *inhibitor* , the soluble receptor , on spontaneous sleep and sleep rebound after sleep deprivation . Negative_regulation IL1B IL1A 18573490 1935044 Furthermore , LYR-71 down-regulated LPS induced transcription of or other cytokines in the cells , and *inhibited* expression vector IKKbeta elicited [IL-1beta] promoter activity . Negative_regulation IL1B IL1A 2530111 120544 The binding of [125I-IL-1 beta] was *inhibited* by and -1 beta with Ki values of 0.27 +/- 0.020 nM and 0.74 +/- 0.12 nM . Negative_regulation IL1B IL1A 2788284 116864 In addition , simultaneous stimulation with recombinant ( alpha or beta ) and recombinant TNF *resulted* in a synergistic increase in [IL-1 beta] mRNA levels . Negative_regulation IL1B IL1A 2969918 95661 In competitive binding experiments , *inhibited* binding of 125I-IL-1 alpha with a Ki of 33-36 pM ( n = 2 ) and binding of [125I-IL-1 beta] with a Ki of 51-63 pM ( n = 2 ) . Negative_regulation IL1B IL1A 7615809 315130 Type I IL-1sR ( IL-1sRI ) preferentially inhibited IL-1 alpha , whereas type II ( IL-1sRII ) mainly *inhibited* [IL-1 beta] . Negative_regulation IL1B IL1A 9249578 446838 To evaluate the *role* of residual production in [IL-1 beta] -/- mice , we used IL-1-receptor antagonist (IL-1ra) . Negative_regulation IL1B IL1R1 9558181 500150 Diacerhein and rhein can effectively *inhibit* the synthesis of [IL-1beta] on human OA synovium , as well as the action of this cytokine at the cartilage level , by reducing the number of chondrocyte . Negative_regulation IL1B IL1R2 19026558 2017056 Ectopic expression of specifically *blocked* exogenous [IL-1beta] signaling but increased expression of the precursor form of IL-1alpha ( pIL-1alpha ) and its downstream targets , including interleukin 6 (IL-6) , interleukin 8 (IL-8) , and type I collagen alpha1 ( COL1A1 ) . Negative_regulation IL1B IL1RN 10448599 637122 The presence of or antisense ICE also *suppressed* the endogenous [IL-1 beta] production of AML cells , at both the level of pro-IL-1 beta and mature IL-1 beta . Negative_regulation IL1B IL1RN 11146371 762888 Since production of IL-1ra in human endometrium is reported to be 10- to 30-fold higher than that of IL-1 alpha/beta , we investigated whether endogenous [IL-1 beta] secreted from human endometrial stromal cells can be *inhibited* by by using an in vitro decidualization culture . Negative_regulation IL1B IL1RN 1415654 201557 A human recombinant ( IL-1ra ) recognizes the two known IL-1 receptors and *blocks* the binding and many biological effects of both IL-1 alpha and [IL-1 beta] . Negative_regulation IL1B IL1RN 14566449 1165135 Interestingly , both , the [IL-1beta-] and TNFalpha-effect could be *blocked* by , indicating that also the TNFalpha induced RGS16 expression is mediated by IL-1 . Negative_regulation IL1B IL1RN 15318032 1286376 It is known that binds to IL-1 receptors and *inhibits* the receptor binding of IL-1alpha and [IL-1beta] . Negative_regulation IL1B IL1RN 1533322 186467 Excess unlabeled IL-1 beta or *blocked* the binding of [125I-IL-1 beta] to the IL-1RtII . Negative_regulation IL1B IL1RN 1533323 186469 added to PBMC 4 or 8 hours after stimulation with LPS still *inhibited* [IL-1 beta] synthesis by 44 % ( P less than .001 ) or 25 % ( P = .01 ) , respectively . Negative_regulation IL1B IL1RN 1533323 186470 The steady state messenger RNA levels of [IL-1 beta] were *reduced* in PBMC stimulated by LPS in the presence of . Negative_regulation IL1B IL1RN 15358691 1293566 However , the [IL-1beta] *inhibitors* , and soluble IL-1 receptor type II ( sIL-1RII ) , regulate IL-1beta bioactivity . Negative_regulation IL1B IL1RN 1830582 163632 The binding of [125I-IL-1 beta] to PMN was competively *inhibited* by . Negative_regulation IL1B IL1RN 18372199 1957978 Antigen induced release of [IL-1beta] and KC/CXCL1 was reduced in TNFR1-/- mice , and TNF-alpha induced hypernociception was *inhibited* by and reparixin . Negative_regulation IL1B IL1RN 18389438 1893233 Lycopene *induced* a dose dependent increase in [IL1beta] , and TNFalpha production and a decrease in IL-2 , IL-10 and IFNgamma secretion , whereas that of IL-6 and was not affected . Negative_regulation IL1B IL1RN 18854211 2021385 Recently , we demonstrated that the interleukin (IL)-1beta arm of the neuroimmune system was critical to the sickness symptoms caused by hypoxia , and that , [IL-1beta] 's endogenous *inhibitor* , was critical to promoting sickness recovery . Negative_regulation IL1B IL1RN 19073760 2035614 ( IL-1Ra ) , a natural *inhibitor* of [interleukin-1 beta] , has been shown to improve beta-cell function and glycemic control in patients with type 2 diabetes . Negative_regulation IL1B IL1RN 19825520 2148940 Pharmacological inhibition of the mevalonate pathway specifically enhanced the release of IL-1alpha , [IL-1beta] and IL-18 and *inhibited* production by LPS activated PBMCs and THP-1 cells . Negative_regulation IL1B IL1RN 2139669 131354 The recombinant also *blocks* IL-1 alpha and [IL-1 beta] stimulation of PGE2 production in human synovial cells and rabbit articular chondrocytes , and of collagenase production by the synovial cells . Negative_regulation IL1B IL1RN 3262586 97879 The more strongly *suppressed* human recombinant [IL-1 beta] than human recombinant IL-1 alpha . Negative_regulation IL1B IL1RN 7697441 297296 We have shown that AIDS-KS spindle cells express [IL-1 beta] and that *inhibits* KS-spindle cell growth . Negative_regulation IL1B IL1RN 7752112 306812 Conversely , [IL-1 beta] production was not *inhibited* by , irrespective of the concentration used and whether the membranes were LPS stimulated . Negative_regulation IL1B IL1RN 8048540 267131 For mononuclear cells , *inhibited* 6-h LPS- and IL-1 alpha induced [IL-1 beta] release to 66 +/- 4 % ( P = 0.001 by paired t test ) and 39 +/- 7 % ( P = 0.0005 by paired t test ) of control , respectively . Negative_regulation IL1B IL1RN 8048540 267133 In addition , *reduced* both LPS- and IL-1 alpha stimulated [IL-1 beta] mRNA levels to 78 and 37 % of control , respectively . Negative_regulation IL1B IL1RN 8048540 267137 Alveolar macrophages demonstrated variable *induced* suppression of LPS stimulated [IL-1 beta] and TNF-alpha release . Negative_regulation IL1B IL1RN 8132734 251603 IL-4 enhanced LPS induced production by PMN and *inhibited* LPS induced [IL-1 beta] production . Negative_regulation IL1B IL1RN 8144913 252558 at concentrations achieved in the plasma during IL-2 immunotherapy ( approximately 10 ng/ml ) *inhibited* the in vitro production of [IL-1 beta] and TNF-alpha by IL-2 activated PBMCs by 65 % and 30 % , respectively . Negative_regulation IL1B IL1RN 8348747 227047 In this study , the production of cytokines [IL-1 beta] , tumour necrosis factor-alpha (TNF-alpha) , IL-6 and the naturally occurring *inhibitor* of IL-1 , , have been investigated in infants and children undergoing Swenson 's pull-through operation for Hirschsprung 's disease . Negative_regulation IL1B IL1RN 8379462 230098 competitively *inhibits* binding of both IL-1 alpha and [IL-1 beta] to cell surface receptors without inducing any discernible intracellular responses . Negative_regulation IL1B IL1RN 8568265 350980 Acute phase levels of C-reactive protein enhance IL-1 beta and production by human blood monocytes but *inhibit* [IL-1 beta] and IL-1ra production by alveolar macrophages . Negative_regulation IL1B IL1RN 8594005 342024 Exercise *induced* a decrease of LPS stimulated production of [IL-1 beta] and TNF-alpha , whereas production of was unchanged . Negative_regulation IL1B IL1RN 8809146 383078 IgA induced higher levels of than Haemophilus influenzae type b ( Hib ) expressing lipopolysaccharide (LPS) , purified LPS or phorbol myristate acetate ( PMA ) , without induction of IL-1 beta release , and even *inhibited* LPS induced [IL-1 beta] release . Negative_regulation IL1B IL1RN 8814267 383520 In contrast , IL-12 stimulated the production of [IL-1 beta] and MCP-1 in TNF-alpha stimulated MNC and *inhibited* synthesis in cytokine stimulated cells . Negative_regulation IL1B IL1RN 8938739 398434 To evaluate the role of Interleukin-1 beta in the pathogenesis of excitotoxic injury , we sought to determine if , an endogenous competitive *inhibitor* of [Interleukin-1 beta] , could attenuate N-methyl-D-aspartate induced injury . Negative_regulation IL1B IL1RN 9643454 514458 Recombinant bovine produced in Escherichia coli *suppressed* the growth inhibitory activity of bovine [IL-1beta] on A375 cells in a dose dependent manner , indicating that the present bovine IL-1ra cDNA encodes biologically active proteins . Negative_regulation IL1B IL1RN 9783809 540700 RA enhanced [IL-1beta] and *inhibited* production by 4beta phorbol 12beta-myristate-13alpha acetate ( PMA ) - and lipopolysaccharide (LPS) stimulated human alveolar macrophages . Negative_regulation IL1B IL1RN 9811059 545561 MTX had fewer effects on phenotypic differentiation of human BMMC and PBMC , but did stimulate release and *inhibit* [IL-1beta] synthesis in BMMC . Negative_regulation IL1B IL2 12444457 1017434 ELISA ( protein level ) and RNAse protection assay ( mRNA level ) showed that SGE *enhanced* interleukin (IL)-1alpha , [IL-1beta] , IL-1Ra , IL-6 , and IL-12p40 cytokines , whereas production of , IL-5 , IL-10 , and IL-13 was decreased . Negative_regulation IL1B IL2 1387585 196242 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL2 15048152 1225140 We have shown that the sera of lung cancer patients affect the response of ConA stimulated normal peripheral blood mononuclear cells by decreasing the expression of and *inhibiting* the release of [IL-1beta] and IL-2 . Negative_regulation IL1B IL2 19762486 2168298 Stimulation of CD56+ cells containing both DCs and abundant gammadelta T cells with zoledronate and *resulted* in the rapid expansion of gammadelta T cells as well as in IFN-gamma , TNF-alpha , and [IL-1beta] but not in IL-4 , IL-10 , or IL-17 production . Negative_regulation IL1B IL2 2138997 131272 TSH , and other peptide hormones did not *inhibit* the binding of [125I-IL-1 beta] to thyroid cells . Negative_regulation IL1B IL20 1387585 196243 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL21 1387585 196244 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL22 1387585 196227 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL22 19536150 2142411 IL-4 and significantly *reduced* HO-1 mRNA and protein expression , whereas [IL-1beta] , IL-17A , and tumor necrosis factor-alpha (TNF-alpha) increased it . Negative_regulation IL1B IL24 1387585 196225 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL25 1387585 196226 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL26 1387585 196231 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL27 1387585 196232 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL2RA 11758206 887633 The expression of [IL-1 beta] , IL-4 , IL-10 , IFN gamma was up-regulated , and the expression of IL-2 , , IL-5 , IL-6 , TNF alpha was significantly *inhibited* in group A . Negative_regulation IL1B IL2RG 9558115 500062 Studies with Abs to gammac and an IL-4 mutant that is unable to bind to gammac showed that IL-4 can suppress [IL-1beta] but not TNF-alpha production by LPS stimulated monocytes in the *presence* of little or no functioning . Negative_regulation IL1B IL3 1387585 196245 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL31 1387585 196233 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL32 1387585 196230 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL33 1387585 196229 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL34 1387585 196234 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL37 1387585 196228 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL4 10692048 670703 In addition , and IL-10 neutralization did not *result* in enhanced [IL-1beta] production in Th2/monocyte co-cultures . Negative_regulation IL1B IL4 10719355 676940 LPS induced levels of [IL-1beta] were *suppressed* by IL-10 , but not by and TGF-beta1/beta2 . Negative_regulation IL1B IL4 10954049 724512 Production of tumor necrosis factor (TNF)-alpha and [IL-1beta] by mouse mesangial cells was not blocked by SSA but production of by these cells was *inhibited* by it ( > 0.1 mM ) . Negative_regulation IL1B IL4 11491045 845684 markedly *reduced* the production of [IL-1 beta] and tumour necrosis factor-a ( TNF-alpha ) by the gastric mononuclear cells of H. pylori infected patients ( P < 0.01 ) . Negative_regulation IL1B IL4 11886168 919892 *inhibited* the secretion of [IL-1beta] and strongly increased that of IL-1ra ; Negative_regulation IL1B IL4 11908571 923614 The antiinflammatory cytokine *blocked* LTB4 dependent stimulation of [IL-1beta] and TNF-alpha synthesis . Negative_regulation IL1B IL4 11991671 938515 While IL-4 can suppress LPS induced interleukin beta (IL-beta) and tumour necrosis factor alpha (TNF-alpha) production by monocytes , can *suppress* LPS induced [IL-1 beta] , but not TNFalpha production by the more differentiated cells . Negative_regulation IL1B IL4 11991671 938528 In addition , like monocytes and MDMac , IFNalpha treated monocytes expressed normal levels of the IL-4 receptor alpha chain and significantly *suppressed* LPS induced [IL-1 beta] production . Negative_regulation IL1B IL4 12034035 948195 A second mechanism , apparent some 48 h after exposure to IFN-gamma , involved a significant suppression of IL-4 receptor (IL-4R) expression at the cell surface , and this correlated with the loss of additional functional responses to IL-4 , including *induced* suppression of LPS induced [IL-1beta] production . Negative_regulation IL1B IL4 12111847 963561 The LPS induced secretion of IL-1beta and TNF-alpha was only reduced after application of ACM , whereas or IL-10 did not *inhibit* [IL-1beta-] or TNF-alpha secretion . Negative_regulation IL1B IL4 1386862 193423 We have previously shown that *reduces* steady state messenger RNA ( mRNA ) levels for [IL-1 beta] in human monocytes by decreasing both IL-1 beta transcription and the t1/2 of newly formed IL-1 beta mRNA transcripts . Negative_regulation IL1B IL4 1386862 193424 Furthermore , although *suppressed* expression of both [IL-1 beta] and IL-6 , it up-regulated synthesis of IL-1ra mRNA and protein . Negative_regulation IL1B IL4 1387585 196246 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL4 1526281 197234 *inhibits* LPS- , [IL-1 beta-] and TNF alpha induced expression of tissue factor in endothelial cells and monocytes . Negative_regulation IL1B IL4 1533284 186444 *suppressed* LPS induced [IL-1 beta] mRNA accumulation and synthesis . Negative_regulation IL1B IL4 1551940 184083 *inhibited* the production of IL-6 , [IL-1 beta] , and tumor necrosis factor alpha (TNF alpha) by both controls and rheumatoid patients . Negative_regulation IL1B IL4 15527169 1329592 In contrast , and IL-10 *inhibit* LPS or [IL-1beta] induced pro-inflammatory cytokine production . Negative_regulation IL1B IL4 15930749 1414597 Both CHD and MCHD also potently reduced the mRNA levels of cyclooxygenase (COX)-2 , interferon (IFN)-gamma and increased in oxazolone applied mouse ears , but weakly *inhibited* that of [IL-1beta] and TNF-alpha . Negative_regulation IL1B IL4 17250684 1725049 We also report that Abeta induced increases in expression of MHCII and [IL-1beta] were similarly *attenuated* by and minocycline in glial cultures prepared from neonatal rats . Negative_regulation IL1B IL4 18025126 1827595 The CCL20 production by synoviocytes is augmented in vitro by [IL-1beta] , IL-17 , or tumor necrosis factor alpha , and is *suppressed* by IFN-gamma or . Negative_regulation IL1B IL4 19536150 2142412 and IL-22 significantly *reduced* HO-1 mRNA and protein expression , whereas [IL-1beta] , IL-17A , and tumor necrosis factor-alpha (TNF-alpha) increased it . Negative_regulation IL1B IL4 2110990 132884 can also *suppress* the increased release of [IL-1 beta] and TNF alpha by monocytes incubated with indomethacin , a non-steroidal anti-inflammatory drug . Negative_regulation IL1B IL4 2114443 135641 Northern dot blot analyses revealed that not only dramatically *reduced* the steady-state [IL-1 beta] mRNA levels in LPS stimulated monocytes , but also those of TNF-alpha and IL-6 . Negative_regulation IL1B IL4 2119829 141841 *inhibits* secretion of [IL-1 beta] , tumor necrosis factor alpha , and IL-6 by human monocytes . Negative_regulation IL1B IL4 2119829 141850 was found to *inhibit* the secretion of [IL-1 beta] and TNF alpha by activated monocytes almost 100 % . Negative_regulation IL1B IL4 2129394 150641 In the *presence* of steady state levels of [IL-1 beta] and IL-6 mRNA were decreased even if cells were co-stimulated with polyclonal activators such as PMA , PWM or PHA . Negative_regulation IL1B IL4 2785566 111572 RNA hybridization studies demonstrated that *suppressed* the expression of IL-1 alpha , [IL-1 beta] , and TNF mRNA . Negative_regulation IL1B IL4 7506581 240002 When tested by enzyme linked immunosorbent assay ( ELISA ) , *suppressed* cellular [IL-1 beta] production , and , similar to IL-4 , anti-IL-1 beta neutralizing antibodies inhibited CFU-GM colony growth , suggesting that the inhibition of endogenous IL-1 beta is a factor in regulating the IL-4 effect . Negative_regulation IL1B IL4 7628587 316511 was found to markedly *inhibit* the release of IL-1 alpha and [IL-1 beta] into the conditioned medium in a dose dependent manner . Negative_regulation IL1B IL4 7640349 317851 The medium nitrite accumulation , as an index of nitric oxide formation , was not influenced by IL-4 ( 10 ng/ml ) alone , whilst [IL-1 beta] stimulation of medium nitrite was partly *reduced* by . Negative_regulation IL1B IL4 7790026 313160 IL-10 and *suppressed* equally [IL-1 beta] production by the same cells . Negative_regulation IL1B IL4 7803192 243803 Recombinant and IL-6 on their own *suppressed* the production of [IL-1 beta] , TNF-alpha , IL-2 and IFN-gamma by mononuclear cells . Negative_regulation IL1B IL4 7852846 294756 , IL-10 , and IL-13 *suppressed* the generation of antitumor activity and cytokine production ( [IL-1 beta] and TNF-alpha ) of monocytes stimulated with MCAF plus norMDP or LPS . Negative_regulation IL1B IL4 7930948 275147 [Interleukin-1 beta] expression was completely *inhibited* by . Negative_regulation IL1B IL4 8038234 265369 , a product of the T-helper 0 ( Th0 ) and 2 ( Th2 ) subset , was originally described as a B-cell stimulatory factor and has subsequently been found to *suppress* IL-1 alpha , [IL-1 beta] , IL-6 , IL-8 , and TNF-alpha gene expression in monocytes stimulated with LPS , and to upregulate IL-1 receptor antagonist (IL1-RA) gene expression . Negative_regulation IL1B IL4 8038234 265373 *down-regulated* mRNA accumulation of the proinflammatory cytokines [IL-1 beta] , IL-8 , and TNF-alpha in monocytes stimulated with IL-2 , IL-3 , and GM-CSF . Negative_regulation IL1B IL4 8132734 251604 enhanced LPS induced IL-1ra production by PMN and *inhibited* LPS induced [IL-1 beta] production . Negative_regulation IL1B IL4 8260535 238828 Interferon-gamma overcomes the glucocorticoid mediated and the *mediated* inhibition of [interleukin-1 beta] synthesis in human monocytes . Negative_regulation IL1B IL4 8260535 238831 Both dexamethasone and dose-dependently *inhibited* IL-1 beta mRNA and [IL-1 beta] protein synthesis after stimulation with LPS ( 300 ng/ml ) ; Negative_regulation IL1B IL4 8325511 223344 Porcine [IL-1 beta] is *down-regulated* by dexamethasone , polymyxin B , and in a fashion kinetically similar to the other reported species . Negative_regulation IL1B IL4 8409448 233442 Herein , we show that strongly *inhibited* PDGF and [IL-1 beta] stimulated rheumatoid arthritis synoviocyte proliferation in a dose dependent manner and through its 130 kDa receptor . Negative_regulation IL1B IL4 8596138 342144 alone *inhibited* the production of [IL-1 beta] , IL-6 , and IL-8 by 32 , 35 , and 50 % , respectively . Negative_regulation IL1B IL4 9384286 466254 *inhibits* secretion of [interleukin-1beta] in the response of human cells to mycobacterial heat shock proteins . Negative_regulation IL1B IL4 9384286 466255 In this study , we found that significantly *suppressed* [IL-1beta] secretion induced by BCG and the 70- and 65-kDa HSP . Negative_regulation IL1B IL4 9558115 500058 In contrast , consistently *down-regulated* [IL-1beta] production by cultured monocytes . Negative_regulation IL1B IL4 9558115 500063 Studies with Abs to gammac and an IL-4 mutant that is unable to bind to gammac showed that can *suppress* [IL-1beta] but not TNF-alpha production by LPS stimulated monocytes in the presence of little or no functioning gammac . Negative_regulation IL1B IL4 9558115 500066 also *suppressed* [IL-1beta] but not TNF-alpha production by Mono Mac 6 cells , which express minimal levels of gammac . Negative_regulation IL1B IL4 9870074 556735 Both IL-10 and *inhibited* [IL-1 beta-] and TNF-alpha induced PGE2 production but had no significant effects on the production of PGE2 under basal conditions . Negative_regulation IL1B IL5 1387585 196247 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL6 10482376 643827 did not alter NIS functional activity , but [IL-1beta] *suppressed* iodide accumulation by approximately 25 % . Negative_regulation IL1B IL6 10603404 655258 In contrast to the response to LPS , where TNF-alpha , IL-1beta , , and IL-8 appear almost simultaneously , the human monocyte response to GBS results in the production of TNF-alpha but *delayed* appearance of [IL-1beta] , IL-6 , and IL-8 . Negative_regulation IL1B IL6 12957790 1137951 Whereas the [IL-1beta-deprivation] signal *induced* a decrease in expression and release of normoxic neurones , it provoked an increase in IL-6 protein in hypoxic neurones . Negative_regulation IL1B IL6 1387585 196248 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL6 1404130 199614 In contrast , flurbiprofen completely abolished production by both cell lines and substantially *inhibited* [IL-1 beta] and TNF alpha production . Negative_regulation IL1B IL6 15265664 1275320 UCB leads to an increase of extracellular glutamate and highly *enhances* the release of TNF-alpha and [IL-1beta] , while inhibiting the production of . Negative_regulation IL1B IL6 18389438 1893234 Lycopene *induced* a dose dependent increase in [IL1beta] , and TNFalpha production and a decrease in IL-2 , IL-10 and IFNgamma secretion , whereas that of and IL-1ra was not affected . Negative_regulation IL1B IL6 18480275 1910667 Consistently , TNFalpha and [IL-1beta] enhanced AMPA- or NMDA induced currents , and IL-1beta and *suppressed* GABA- and glycine induced currents . Negative_regulation IL1B IL6 19406240 2095650 In PC-3 cells , IL-1beta stimulated and OPG release , and dexamethasone dose-dependently *inhibited* IL-1beta-inducible IL-6 release , and constitutive and [IL-1beta-inducible] OPG release . Negative_regulation IL1B IL6 20456417 2288479 In the presence of LPS , LcS enhanced [IL-1beta] production but *inhibited* LPS induced IL-10 and production , and had no further effect on TNF-alpha and IL-12 production . Negative_regulation IL1B IL6 2294996 127512 did not stimulate IL-1 beta or TNF production , but *suppressed* [IL-1 beta] and TNF production induced by LPS or PHA by 30 % ( P less than .01 ) . Negative_regulation IL1B IL6 7803192 243804 Recombinant IL-4 and on their own *suppressed* the production of [IL-1 beta] , TNF-alpha , IL-2 and IFN-gamma by mononuclear cells . Negative_regulation IL1B IL6 8033802 264126 Vasopressin and oxytocin ( 1 microM ) inhibited LPS and [IL-1 beta] stimulation of IL-6 release from NIL cells , but did not *inhibit* release from AP cells . Negative_regulation IL1B IL6 9334851 457931 Lipopolysaccharide (LPS) induced in vitro TNF-alpha production by human peripheral blood mononuclear cells , measured by enzyme linked immunosorbent assay ( ELISA ) , was significantly inhibited with more than 1 x 10 ( -3 ) mol/l of nicotinamide , while [interleukin-1-beta] was not inhibited and was slightly *inhibited* even with 10 ( -2 ) mol/l. Oral administration of nicotinamide with more than 62.5 mg/kg also significantly inhibited LPS induced serum TNF-alpha production measured by ELISA and bioassay in Balb/c mice . Negative_regulation IL1B IL6 9878816 583803 The *role* of in the activation of the hypothalamo-pituitary-adrenocortical axis and brain indoleamines by endotoxin and [interleukin-1 beta] . Negative_regulation IL1B IL7 1387585 196249 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL8 10603404 655259 In contrast to the response to LPS , where TNF-alpha , IL-1beta , IL-6 , and appear almost simultaneously , the human monocyte response to GBS results in the production of TNF-alpha but *delayed* appearance of [IL-1beta] , IL-6 , and IL-8 . Negative_regulation IL1B IL8 1387585 196250 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B IL8 19229069 2054629 Additionally , *reduced* p38 activation and NF-kappaB activity induced by [IL-1beta] alone . Negative_regulation IL1B IL8 19513849 2098375 In the mononuclear cell and neutrophil fractions , beta-endorphin and the delta agonist DADLE increased [IL-1beta] synthesis in both the spontaneous and stimulated versions of the test , while beta-endorphin and the delta agonist DADLE *inhibited* production in the mononuclear cell and neutrophil fractions only in LPS stimulated cultures . Negative_regulation IL1B IL9 1387585 196251 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Negative_regulation IL1B INHBA 18321725 1891888 is a member of transforming growth factor beta ( TGF-beta ) superfamily , which is also named restrictin-P , and can *inhibit* the secretion of nitric oxide ( NO ) and [interleukin-1beta (IL-1beta)] from LPS activated mouse macrophages . Negative_regulation IL1B INHBA 9712365 527260 In the present study , we showed that *inhibited* the production of [interleukin-1beta (IL-1beta)] , a potent proinflammatory cytokine , and enhanced the production of IL-1 receptor antagonist (IL-1ra) , in activated THP-1 and U-937 human monocytic cells , resulting in the reduction of IL-1 biologic activity . Negative_regulation IL1B INHBA 9712365 527266 Although activin A inhibited the production of mature IL-1beta in activated U-937 cells , the relative protein expression of pro-IL-1beta was unaltered by activin A , suggesting that *inhibits* [IL-1beta] production by blocking proteolytic conversion of pro-IL-1beta into mature IL-1beta . Negative_regulation IL1B INS 16644698 1553153 [IL-1beta] alone *induced* a strong inhibition of secretion and glucose oxidation rate and a marked increase in medium nitrite accumulation as an indicator of nitric oxide generation . Negative_regulation IL1B INS 7530759 291723 In contrast , [IL-1 beta] *induces* the expression of iNOS and also inhibits secretion by both intact islets and Facs purified beta cells , whereas TNF+LPS have no inhibitory effects on insulin secretion by purified beta cells . Negative_regulation IL1B IRAK1 11583588 865685 To study the *role* of in [IL-1 beta] signalling , we have generated a set of IRAK-1 variants that express distinct domains of IRAK-1 either alone or in combination and have examined their effects on an NF-kappa B-responsive reporter in HeLa cells . Negative_regulation IL1B IRAK1 19342688 2056844 The *role* and relative contribution of MyD88 , , and TRAF6 adaptor proteins in [IL-1beta] regulation of aggrecanase-1 ( ADAMTS-4 ) is unknown . Negative_regulation IL1B IRAK4 19060282 2047443 Inhibition of the IL-1 receptor using an antagonist ( IL-1ra ; 50 ng/mL ) or *inhibition* of [IL-1beta] production using a specific caspase-1 inhibitor ( YVAD-fmk ; 100 microM ) significantly decreased high glucose induced GAPDH nuclear accumulation . Negative_regulation IL1B IRAK4 9658753 517165 Conversely , neutralization of endogenous IL-10 was found to augment both tumor necrosis factor-alpha and [IL-1 beta] production and *inhibit* antagonist production . Negative_regulation IL1B ISL1 19169644 2061125 markedly *suppressed* LPS induced NO , [IL-1beta] , and TNF-alpha production . Negative_regulation IL1B ISL2 19169644 2061124 markedly *suppressed* LPS induced NO , [IL-1beta] , and TNF-alpha production . Negative_regulation IL1B ITGAL 9712747 527380 Furthermore , Northern blot analyses showed that the fimbria induced expression of [IL-1beta] and TNF-alpha genes in the cells was *inhibited* strongly by CD18 antibody treatment and slightly by , CD11b , or CD11c antibody treatment . Negative_regulation IL1B ITGAM 22138247 2562896 Both doses of DAS suppressed endotoxin induced neutrophilia , serum levels of sICAM-1 and CINC-1 , cellular CD11b on neutrophils , and intestinal contents of ICAM-1 , CINC-1 , TNF-alpha , and IL-1beta ( p < 0.05 ) . DADS suppressed endotoxin induced intestinal contents of ICAM-1 , TNF-alpha , and IL-1beta at both doses , but only suppressed the serum sICAM-1 level and cellular on neutrophils at the low dose ( p < 0.05 ) . DATS did not ameliorate the endotoxin induced serum level of sICAM-1 or CINC-1 but *suppressed* intestinal [IL-1beta] at both doses. The low but not the high dose of DATS also ameliorated the intestinal contents of ICAM-1 and TNF-alpha ( p < 0.05 ) . All GSCs reversed endotoxin induced neutrophil infiltration and damage in the intestine , and the order of the effects of these GSCs to normalize intestinal morphology was DAS > DADS > DATS . Negative_regulation IL1B ITGAM 9712747 527381 Furthermore , Northern blot analyses showed that the fimbria induced expression of [IL-1beta] and TNF-alpha genes in the cells was *inhibited* strongly by CD18 antibody treatment and slightly by CD11a , , or CD11c antibody treatment . Negative_regulation IL1B JUN 15146413 1247760 The mRNA up-regulation of IL-8 and [IL-1beta] by MIF was *inhibited* by 2 tyrosine kinase inhibitors , a protein kinase C ( PKC ) inhibitor , an inhibitor , and by an NF-kappaB inhibitor . Negative_regulation IL1B JUN 15996190 1430190 However , JNK Inhibitor II , a specific inhibitor of *prevented* the [IL-1beta] mRNA expression induced by Y4 CP in a concentration dependent manner . Negative_regulation IL1B JUN 19723085 2133845 We found that omega-3 fatty acids , such as docosahexaenoic acid ( DHA ) and alpha-linolenic acid ( ALA ) , suppressed the expression of inflammatory cytokines ( [IL-1beta] , IL-6 ) and *inhibited* the activation of transcription factor in cerulein stimulated pancreatic acinar cells . Negative_regulation IL1B JUN 19748795 2153103 ZD 7155 also reduced the mRNA expression of TNF-alpha and [IL-1 beta] , *inhibited* the activation of NF-kappaB and , and improved lung histopathology . Negative_regulation IL1B JUN 8386622 217819 We have now examined the *role* of in the regulation of the [IL-1 beta] gene expression by PKC and cAMP in THP-1 cells . Negative_regulation IL1B LPA 8690807 372653 Oxidized low density *inhibits* lipopolysaccharide induced binding of nuclear factor-kappaB to DNA and the subsequent expression of tumor necrosis factor-alpha and [interleukin-1beta] in macrophages . Negative_regulation IL1B LSM4 12047757 950226 We found that msa reduced the expression of [IL-1beta] , Cox-2 , and MHC II but stimulated TNF-alpha while hly , rsh and *stimulated* MHC II but down-regulated TNF-alpha . Negative_regulation IL1B LTA 18501625 1928140 We found that ApoA-I could attenuate induced acute lung injury and inflammation and significantly *inhibit* LTA induced [IL-1beta] and TNF-alpha accumulation in the serum ( P < 0.01 and P < 0.05 , respectively ) , as well as in bronchoalveolar lavage (BAL) fluid ( P < 0.01 and P < 0.05 , respectively ) . Negative_regulation IL1B LTB 8016588 262662 We examined the *role* of in the production of [Interleukin-1 beta (IL-1 beta)] by rheumatoid synovial cells since a substantial amount of LTB4 has been detected in the synovial fluid from patients with rheumatoid arthritis . Negative_regulation IL1B MAP2K1 15665520 1365593 The study shows that PI3K but not inhibition *resulted* in the loss of hypoxic and [IL-1beta] induced HIF-1alpha accumulation , whereas VEGF synthesis was reduced by either intervention . Negative_regulation IL1B MAPK1 10228013 610592 The *role* of p38 in [IL-1 beta] transcription . Negative_regulation IL1B MAPK1 10228013 610631 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Negative_regulation IL1B MAPK1 10228013 610685 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Negative_regulation IL1B MAPK1 12115737 964333 When Caco-2 cells were treated with [IL-1beta] in the *presence* of the inhibitor , PD-98059 , IL-6 mRNA and protein levels were reduced by the same concentrations of PD-98059 that inhibited C/EBP DNA binding activity in previous studies . Negative_regulation IL1B MAPK1 17530716 1751475 Blocking of p38 , but not , *resulted* in inhibition of both LPS mediated [IL-1beta] gene expression and the negative effects of LPS on matrix biosynthesis . Negative_regulation IL1B MAPK1 18669445 1973074 DPML significantly inhibited tumor necrosis factor alpha , [interleukin-1beta] , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 activation in the lung . Negative_regulation IL1B MAPK1 19961838 2199472 Inhibition of p38 in microglia *leads* to an increased level of [IL1beta] , while inhibition of all three MAPKs suppressed the release of nitrite . Negative_regulation IL1B MAPK10 10228013 610593 The *role* of p38 in [IL-1 beta] transcription . Negative_regulation IL1B MAPK10 10228013 610632 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Negative_regulation IL1B MAPK10 10228013 610686 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Negative_regulation IL1B MAPK10 12115737 964334 When Caco-2 cells were treated with [IL-1beta] in the *presence* of the inhibitor , PD-98059 , IL-6 mRNA and protein levels were reduced by the same concentrations of PD-98059 that inhibited C/EBP DNA binding activity in previous studies . Negative_regulation IL1B MAPK10 18669445 1973075 DPML significantly inhibited tumor necrosis factor alpha , [interleukin-1beta] , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 activation in the lung . Negative_regulation IL1B MAPK10 19961838 2199473 Inhibition of p38 in microglia *leads* to an increased level of [IL1beta] , while inhibition of all three MAPKs suppressed the release of nitrite . Negative_regulation IL1B MAPK11 10228013 610594 The *role* of p38 in [IL-1 beta] transcription . Negative_regulation IL1B MAPK11 10228013 610633 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Negative_regulation IL1B MAPK11 10228013 610687 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Negative_regulation IL1B MAPK11 12115737 964335 When Caco-2 cells were treated with [IL-1beta] in the *presence* of the inhibitor , PD-98059 , IL-6 mRNA and protein levels were reduced by the same concentrations of PD-98059 that inhibited C/EBP DNA binding activity in previous studies . Negative_regulation IL1B MAPK11 18669445 1973076 DPML significantly inhibited tumor necrosis factor alpha , [interleukin-1beta] , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 activation in the lung . Negative_regulation IL1B MAPK11 19961838 2199474 Inhibition of p38 in microglia *leads* to an increased level of [IL1beta] , while inhibition of all three MAPKs suppressed the release of nitrite . Negative_regulation IL1B MAPK12 10228013 610595 The *role* of p38 in [IL-1 beta] transcription . Negative_regulation IL1B MAPK12 10228013 610634 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Negative_regulation IL1B MAPK12 10228013 610688 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Negative_regulation IL1B MAPK12 12115737 964336 When Caco-2 cells were treated with [IL-1beta] in the *presence* of the inhibitor , PD-98059 , IL-6 mRNA and protein levels were reduced by the same concentrations of PD-98059 that inhibited C/EBP DNA binding activity in previous studies . Negative_regulation IL1B MAPK12 18669445 1973077 DPML significantly inhibited tumor necrosis factor alpha , [interleukin-1beta] , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 activation in the lung . Negative_regulation IL1B MAPK12 19961838 2199475 Inhibition of p38 in microglia *leads* to an increased level of [IL1beta] , while inhibition of all three MAPKs suppressed the release of nitrite . Negative_regulation IL1B MAPK13 10228013 610596 The *role* of p38 in [IL-1 beta] transcription . Negative_regulation IL1B MAPK13 10228013 610635 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Negative_regulation IL1B MAPK13 10228013 610689 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Negative_regulation IL1B MAPK13 12115737 964337 When Caco-2 cells were treated with [IL-1beta] in the *presence* of the inhibitor , PD-98059 , IL-6 mRNA and protein levels were reduced by the same concentrations of PD-98059 that inhibited C/EBP DNA binding activity in previous studies . Negative_regulation IL1B MAPK13 18669445 1973078 DPML significantly inhibited tumor necrosis factor alpha , [interleukin-1beta] , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 activation in the lung . Negative_regulation IL1B MAPK13 19961838 2199476 Inhibition of p38 in microglia *leads* to an increased level of [IL1beta] , while inhibition of all three MAPKs suppressed the release of nitrite . Negative_regulation IL1B MAPK14 10228013 610597 The *role* of p38 in [IL-1 beta] transcription . Negative_regulation IL1B MAPK14 10228013 610636 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Negative_regulation IL1B MAPK14 10228013 610690 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Negative_regulation IL1B MAPK14 12115737 964338 When Caco-2 cells were treated with [IL-1beta] in the *presence* of the inhibitor , PD-98059 , IL-6 mRNA and protein levels were reduced by the same concentrations of PD-98059 that inhibited C/EBP DNA binding activity in previous studies . Negative_regulation IL1B MAPK14 18669445 1973079 DPML significantly inhibited tumor necrosis factor alpha , [interleukin-1beta] , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 activation in the lung . Negative_regulation IL1B MAPK14 19961838 2199477 Inhibition of p38 in microglia *leads* to an increased level of [IL1beta] , while inhibition of all three MAPKs suppressed the release of nitrite . Negative_regulation IL1B MAPK14 22053092 2557278 Biochemical inhibition of MAPK3/1 , but not JNK or , *reduced* LPS induced [IL1B] , IL6 , and IL8 expression in endometrial cells . Negative_regulation IL1B MAPK15 10228013 610591 The *role* of p38 in [IL-1 beta] transcription . Negative_regulation IL1B MAPK15 10228013 610630 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Negative_regulation IL1B MAPK15 10228013 610684 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Negative_regulation IL1B MAPK15 12115737 964332 When Caco-2 cells were treated with [IL-1beta] in the *presence* of the inhibitor , PD-98059 , IL-6 mRNA and protein levels were reduced by the same concentrations of PD-98059 that inhibited C/EBP DNA binding activity in previous studies . Negative_regulation IL1B MAPK15 18669445 1973073 DPML significantly inhibited tumor necrosis factor alpha , [interleukin-1beta] , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 activation in the lung . Negative_regulation IL1B MAPK15 19961838 2199471 Inhibition of p38 in microglia *leads* to an increased level of [IL1beta] , while inhibition of all three MAPKs suppressed the release of nitrite . Negative_regulation IL1B MAPK3 10228013 610598 The *role* of p38 in [IL-1 beta] transcription . Negative_regulation IL1B MAPK3 10228013 610637 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Negative_regulation IL1B MAPK3 10228013 610691 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Negative_regulation IL1B MAPK3 12115737 964339 When Caco-2 cells were treated with [IL-1beta] in the *presence* of the inhibitor , PD-98059 , IL-6 mRNA and protein levels were reduced by the same concentrations of PD-98059 that inhibited C/EBP DNA binding activity in previous studies . Negative_regulation IL1B MAPK3 15031635 1183839 CQ reduced [IL-1 beta] mRNA expression and strongly *inhibited* phosphorylation of mitogen activated protein kinase (MAPK) p38 , and to a lesser extent c-Jun N-terminal kinase and . Negative_regulation IL1B MAPK3 17530716 1751476 Blocking of p38 , but not , *resulted* in inhibition of both LPS mediated [IL-1beta] gene expression and the negative effects of LPS on matrix biosynthesis . Negative_regulation IL1B MAPK3 18669445 1973080 DPML significantly inhibited tumor necrosis factor alpha , [interleukin-1beta] , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 activation in the lung . Negative_regulation IL1B MAPK3 19961838 2199478 Inhibition of p38 in microglia *leads* to an increased level of [IL1beta] , while inhibition of all three MAPKs suppressed the release of nitrite . Negative_regulation IL1B MAPK3 9624172 511377 Differential *roles* of and p38 ( MAPK ) in [interleukin-1beta-] and tumor necrosis factor-alpha induced low density lipoprotein receptor expression in HepG2 cells . Negative_regulation IL1B MAPK4 10228013 610599 The *role* of p38 in [IL-1 beta] transcription . Negative_regulation IL1B MAPK4 10228013 610638 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Negative_regulation IL1B MAPK4 10228013 610692 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Negative_regulation IL1B MAPK4 12115737 964340 When Caco-2 cells were treated with [IL-1beta] in the *presence* of the inhibitor , PD-98059 , IL-6 mRNA and protein levels were reduced by the same concentrations of PD-98059 that inhibited C/EBP DNA binding activity in previous studies . Negative_regulation IL1B MAPK4 18669445 1973081 DPML significantly inhibited tumor necrosis factor alpha , [interleukin-1beta] , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 activation in the lung . Negative_regulation IL1B MAPK4 19961838 2199479 Inhibition of p38 in microglia *leads* to an increased level of [IL1beta] , while inhibition of all three MAPKs suppressed the release of nitrite . Negative_regulation IL1B MAPK6 10228013 610600 The *role* of p38 in [IL-1 beta] transcription . Negative_regulation IL1B MAPK6 10228013 610639 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Negative_regulation IL1B MAPK6 10228013 610693 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Negative_regulation IL1B MAPK6 12115737 964341 When Caco-2 cells were treated with [IL-1beta] in the *presence* of the inhibitor , PD-98059 , IL-6 mRNA and protein levels were reduced by the same concentrations of PD-98059 that inhibited C/EBP DNA binding activity in previous studies . Negative_regulation IL1B MAPK6 18669445 1973082 DPML significantly inhibited tumor necrosis factor alpha , [interleukin-1beta] , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 activation in the lung . Negative_regulation IL1B MAPK6 19961838 2199480 Inhibition of p38 in microglia *leads* to an increased level of [IL1beta] , while inhibition of all three MAPKs suppressed the release of nitrite . Negative_regulation IL1B MAPK7 10228013 610601 The *role* of p38 in [IL-1 beta] transcription . Negative_regulation IL1B MAPK7 10228013 610640 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Negative_regulation IL1B MAPK7 10228013 610694 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Negative_regulation IL1B MAPK7 12115737 964342 When Caco-2 cells were treated with [IL-1beta] in the *presence* of the inhibitor , PD-98059 , IL-6 mRNA and protein levels were reduced by the same concentrations of PD-98059 that inhibited C/EBP DNA binding activity in previous studies . Negative_regulation IL1B MAPK7 18669445 1973083 DPML significantly inhibited tumor necrosis factor alpha , [interleukin-1beta] , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 activation in the lung . Negative_regulation IL1B MAPK7 19961838 2199481 Inhibition of p38 in microglia *leads* to an increased level of [IL1beta] , while inhibition of all three MAPKs suppressed the release of nitrite . Negative_regulation IL1B MAPK8 10228013 610602 The *role* of p38 in [IL-1 beta] transcription . Negative_regulation IL1B MAPK8 10228013 610641 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Negative_regulation IL1B MAPK8 10228013 610695 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Negative_regulation IL1B MAPK8 12115737 964343 When Caco-2 cells were treated with [IL-1beta] in the *presence* of the inhibitor , PD-98059 , IL-6 mRNA and protein levels were reduced by the same concentrations of PD-98059 that inhibited C/EBP DNA binding activity in previous studies . Negative_regulation IL1B MAPK8 17628610 1775146 [IL-1 beta] release and caspase-1 activity induced by DSS were significantly *inhibited* by a MAPK kinase 1/2 inhibitor , a p38 MAPK inhibitor , and NAC , however , not by or a protein kinase C inhibitor . Negative_regulation IL1B MAPK8 18669445 1973084 DPML significantly inhibited tumor necrosis factor alpha , [interleukin-1beta] , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 activation in the lung . Negative_regulation IL1B MAPK8 19961838 2199482 Inhibition of p38 in microglia *leads* to an increased level of [IL1beta] , while inhibition of all three MAPKs suppressed the release of nitrite . Negative_regulation IL1B MAPK9 10228013 610603 The *role* of p38 in [IL-1 beta] transcription . Negative_regulation IL1B MAPK9 10228013 610642 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Negative_regulation IL1B MAPK9 10228013 610696 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Negative_regulation IL1B MAPK9 12115737 964344 When Caco-2 cells were treated with [IL-1beta] in the *presence* of the inhibitor , PD-98059 , IL-6 mRNA and protein levels were reduced by the same concentrations of PD-98059 that inhibited C/EBP DNA binding activity in previous studies . Negative_regulation IL1B MAPK9 18669445 1973085 DPML significantly inhibited tumor necrosis factor alpha , [interleukin-1beta] , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 activation in the lung . Negative_regulation IL1B MAPK9 19961838 2199483 Inhibition of p38 in microglia *leads* to an increased level of [IL1beta] , while inhibition of all three MAPKs suppressed the release of nitrite . Negative_regulation IL1B MAPKAP1 1847694 153509 However , *suppressed* the synthesis of [IL-1 beta] . Negative_regulation IL1B MAPKAPK2 19657354 2186081 Surprisingly , deficiency did not inhibit edema formation in subacute 2,4-dinitrochlorobenzene ( DNCB ) -induced contact allergy and even *increased* TNF-alpha and [IL-1beta] levels as well as granulocyte infiltration in diseased ears . Negative_regulation IL1B MBTPS1 17703957 1873858 significantly *reduced* NO formation and iNOS mRNA and protein expression , both in un-stimulated and [IL-1beta] stimulated bovine chondrocytes . Negative_regulation IL1B MBTPS1 18171908 1883122 Thus , *inhibits* [IL-1beta] induction of NO production and iNOS expression in rat VSMCs through multiple mechanisms involving both PTX-sensitive and -insensitive G proteins coupled to S1P receptors . Negative_regulation IL1B MCAT 20171598 2215473 Induction of [interleukin 1beta (IL-1beta)] , TNF-alpha , and macrophage inflammatory protein-2 ( MIP-2 ) in the colon was *attenuated* by dietary . Negative_regulation IL1B MEFV 14634131 1170918 We also show that expression of the family proteins pyrin or cryopyrin/PYPAF1/NALP3 individually inhibits IL-1beta secretion but that coexpression of ASC with these proteins *results* in enhanced [IL-1beta] secretion . Negative_regulation IL1B MMP2 18782565 1975911 Sinomenine suppressed the production of proinflammatory cytokines [IL-1beta] and IL-6 in serum , *inhibited* the protein expressions and activities of and MMP-9 , and elevated the protein expressions and activities of TIMP-1 and TIMP-3 in rat paw tissues . Negative_regulation IL1B MMP9 18782565 1975912 Sinomenine suppressed the production of proinflammatory cytokines [IL-1beta] and IL-6 in serum , *inhibited* the protein expressions and activities of MMP-2 and , and elevated the protein expressions and activities of TIMP-1 and TIMP-3 in rat paw tissues . Negative_regulation IL1B MMP9 9639100 514016 Both [interleukin-1beta] and tumor necrosis factor alpha *induced* a 4- to 9-fold increase in the level of expression in conditioned media , and a 17- to 24-fold increase in MMP-3 mRNA . Negative_regulation IL1B MSH2 10816651 580231 In research on septic patients , *inhibited* release of TNF-alpha , [interleukin-1 beta (IL-1 beta)] , and interleukin-8 (IL-8) in whole blood samples in vitro . Negative_regulation IL1B MSH2 10816656 580262 , in a dose dependent manner , after 48 h , significantly *reduced* the [IL-1 beta] mediated secretion of the C-X-C chemokines IL-8 and Gro alpha . Negative_regulation IL1B MSH2 11694321 876646 Gamma ( 2 ) <-MSH> *inhibits* LPS induced [IL-1beta] gene expression in the brain , pituitary and thymus , and prevents increases in plasma NO levels . Negative_regulation IL1B MSH2 12453626 1020846 This study 's objective was to determine whether the anti-inflammatory neuropeptide can *suppress* postischemic activation of intracerebral tumor necrosis factor-alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] gene expression . Negative_regulation IL1B MSH2 16118510 1454368 *inhibited* [IL-1beta] or TNF-alpha stimulated IL-8 and MCP-1 protein levels in the media . Negative_regulation IL1B MSH2 8298992 240978 alpha suppressed basal CRH and AVP release in both LEW/N and F344/N rats and *prevented* [IL-1 beta] stimulated CRH secretion in these strains . Negative_regulation IL1B MSH2 9700761 525253 In separate experiments on normal peripheral blood mononuclear cells ( PBMC ) , ( 1-13 ) *inhibited* production of [IL-1 beta] and TNF alpha induced by HIV envelope glycoprotein gp 120 . Negative_regulation IL1B MSH3 10816651 580232 In research on septic patients , *inhibited* release of TNF-alpha , [interleukin-1 beta (IL-1 beta)] , and interleukin-8 (IL-8) in whole blood samples in vitro . Negative_regulation IL1B MSH3 10816656 580263 , in a dose dependent manner , after 48 h , significantly *reduced* the [IL-1 beta] mediated secretion of the C-X-C chemokines IL-8 and Gro alpha . Negative_regulation IL1B MSH3 11694321 876647 Gamma ( 2 ) <-MSH> *inhibits* LPS induced [IL-1beta] gene expression in the brain , pituitary and thymus , and prevents increases in plasma NO levels . Negative_regulation IL1B MSH3 12453626 1020847 This study 's objective was to determine whether the anti-inflammatory neuropeptide can *suppress* postischemic activation of intracerebral tumor necrosis factor-alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] gene expression . Negative_regulation IL1B MSH3 16118510 1454369 *inhibited* [IL-1beta] or TNF-alpha stimulated IL-8 and MCP-1 protein levels in the media . Negative_regulation IL1B MSH3 8298992 240979 alpha suppressed basal CRH and AVP release in both LEW/N and F344/N rats and *prevented* [IL-1 beta] stimulated CRH secretion in these strains . Negative_regulation IL1B MSH3 9700761 525254 In separate experiments on normal peripheral blood mononuclear cells ( PBMC ) , ( 1-13 ) *inhibited* production of [IL-1 beta] and TNF alpha induced by HIV envelope glycoprotein gp 120 . Negative_regulation IL1B MSH4 10816651 580233 In research on septic patients , *inhibited* release of TNF-alpha , [interleukin-1 beta (IL-1 beta)] , and interleukin-8 (IL-8) in whole blood samples in vitro . Negative_regulation IL1B MSH4 10816656 580264 , in a dose dependent manner , after 48 h , significantly *reduced* the [IL-1 beta] mediated secretion of the C-X-C chemokines IL-8 and Gro alpha . Negative_regulation IL1B MSH4 11694321 876648 Gamma ( 2 ) <-MSH> *inhibits* LPS induced [IL-1beta] gene expression in the brain , pituitary and thymus , and prevents increases in plasma NO levels . Negative_regulation IL1B MSH4 12453626 1020848 This study 's objective was to determine whether the anti-inflammatory neuropeptide can *suppress* postischemic activation of intracerebral tumor necrosis factor-alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] gene expression . Negative_regulation IL1B MSH4 16118510 1454370 *inhibited* [IL-1beta] or TNF-alpha stimulated IL-8 and MCP-1 protein levels in the media . Negative_regulation IL1B MSH4 8298992 240980 alpha suppressed basal CRH and AVP release in both LEW/N and F344/N rats and *prevented* [IL-1 beta] stimulated CRH secretion in these strains . Negative_regulation IL1B MSH4 9700761 525255 In separate experiments on normal peripheral blood mononuclear cells ( PBMC ) , ( 1-13 ) *inhibited* production of [IL-1 beta] and TNF alpha induced by HIV envelope glycoprotein gp 120 . Negative_regulation IL1B MSH5 10816651 580234 In research on septic patients , *inhibited* release of TNF-alpha , [interleukin-1 beta (IL-1 beta)] , and interleukin-8 (IL-8) in whole blood samples in vitro . Negative_regulation IL1B MSH5 10816656 580265 , in a dose dependent manner , after 48 h , significantly *reduced* the [IL-1 beta] mediated secretion of the C-X-C chemokines IL-8 and Gro alpha . Negative_regulation IL1B MSH5 11694321 876649 Gamma ( 2 ) <-MSH> *inhibits* LPS induced [IL-1beta] gene expression in the brain , pituitary and thymus , and prevents increases in plasma NO levels . Negative_regulation IL1B MSH5 12453626 1020849 This study 's objective was to determine whether the anti-inflammatory neuropeptide can *suppress* postischemic activation of intracerebral tumor necrosis factor-alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] gene expression . Negative_regulation IL1B MSH5 16118510 1454371 *inhibited* [IL-1beta] or TNF-alpha stimulated IL-8 and MCP-1 protein levels in the media . Negative_regulation IL1B MSH5 8298992 240981 alpha suppressed basal CRH and AVP release in both LEW/N and F344/N rats and *prevented* [IL-1 beta] stimulated CRH secretion in these strains . Negative_regulation IL1B MSH5 9700761 525256 In separate experiments on normal peripheral blood mononuclear cells ( PBMC ) , ( 1-13 ) *inhibited* production of [IL-1 beta] and TNF alpha induced by HIV envelope glycoprotein gp 120 . Negative_regulation IL1B MSH6 10816651 580235 In research on septic patients , *inhibited* release of TNF-alpha , [interleukin-1 beta (IL-1 beta)] , and interleukin-8 (IL-8) in whole blood samples in vitro . Negative_regulation IL1B MSH6 10816656 580266 , in a dose dependent manner , after 48 h , significantly *reduced* the [IL-1 beta] mediated secretion of the C-X-C chemokines IL-8 and Gro alpha . Negative_regulation IL1B MSH6 11694321 876650 Gamma ( 2 ) <-MSH> *inhibits* LPS induced [IL-1beta] gene expression in the brain , pituitary and thymus , and prevents increases in plasma NO levels . Negative_regulation IL1B MSH6 12453626 1020850 This study 's objective was to determine whether the anti-inflammatory neuropeptide can *suppress* postischemic activation of intracerebral tumor necrosis factor-alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] gene expression . Negative_regulation IL1B MSH6 16118510 1454372 *inhibited* [IL-1beta] or TNF-alpha stimulated IL-8 and MCP-1 protein levels in the media . Negative_regulation IL1B MSH6 8298992 240982 alpha suppressed basal CRH and AVP release in both LEW/N and F344/N rats and *prevented* [IL-1 beta] stimulated CRH secretion in these strains . Negative_regulation IL1B MSH6 9700761 525257 In separate experiments on normal peripheral blood mononuclear cells ( PBMC ) , ( 1-13 ) *inhibited* production of [IL-1 beta] and TNF alpha induced by HIV envelope glycoprotein gp 120 . Negative_regulation IL1B MST1 20561679 2285199 Although unmodified and surface modified mSP1000s were taken up with similar frequencies equally into the THP-1 cells , surface modification of dramatically *suppressed* [IL-1beta] production by reducing ROS production . Negative_regulation IL1B MTX1 10498857 647707 After a single intravenous injection ( i.v. ) , and at equivalent doses , both free ( 500 microg ) and MTX-EPC *inhibited* the LPS induced rise in plasma [IL-1beta] levels observed in MTX-PEG and saline treated rats . Negative_regulation IL1B MTX1 14528517 1148987 *reduced* [IL-1beta] levels only in the 6-day treatment . Negative_regulation IL1B MYD88 16517734 1530953 Modification of mRNA splicing and *inhibition* of [IL-1beta] signaling in cell culture and in mice with a 2'-O-methoxyethyl modified oligonucleotide . Negative_regulation IL1B MYD88 19342688 2056845 The *role* and relative contribution of , IRAK1 , and TRAF6 adaptor proteins in [IL-1beta] regulation of aggrecanase-1 ( ADAMTS-4 ) is unknown . Negative_regulation IL1B MYLIP 19008124 2041476 Over-expression of , miR-98 or miR-146 in isolated human chondrocytes *reduced* [interleukin-1 beta (IL-1 beta)] induced TNF-alpha production . Negative_regulation IL1B NA 16445696 1517138 In addition , *diminished* the LPS induced increases in nitrate/nitrite , MG , TNF-a and [IL-1b] . Negative_regulation IL1B NA 17628610 1775147 [IL-1 beta] release and caspase-1 activity induced by DSS were significantly *inhibited* by a MAPK kinase 1/2 inhibitor , a p38 MAPK inhibitor , and , however , not by JNK1/2 or a protein kinase C inhibitor . Negative_regulation IL1B NA 17687726 1781858 The secretion of [IL-1beta] and TNF-alpha by silica exposed AM was markedly *inhibited* by and R6G , suggesting that the production of these cytokines is also ROS dependent . Negative_regulation IL1B NA 18096486 1838276 also *resulted* in significantly fewer macrophages , lymphocytes and neutrophils as well as [IL-1 beta] , keratinocyte cytokine ( KC ) , monocyte chemoattractant protein (MCP)-1 and IL-6 levels in BAL taken after reperfusion . Negative_regulation IL1B NA 19344884 2080900 before LPS significantly *reduced* the fetal IL-6 and [IL-1 beta] response . Negative_regulation IL1B NA 20560295 2181621 The LPS stimulated [IL-1beta] production was also *suppressed* by 10 mM . Negative_regulation IL1B NAB1 19812204 2154340 , but not sodium formate , was found to *inhibit* LPS induced expression of inducible NO synthase (iNOS) , proinflammatory cytokines ( TNF-alpha and [IL-1beta] ) and surface markers ( CD11b , CD11c , and CD68 ) in mouse microglia . Negative_regulation IL1B NAB1 19812204 2154348 Similarly , also *inhibited* fibrillar amyloid beta ( Abeta ) - , prion peptide- , double stranded RNA ( polyinosinic-polycytidylic acid ) - , HIV-1 Tat- , 1-methyl-4-phenylpyridinium ( + ) - , [IL-1beta-] , and IL-12 p40 ( 2 ) -induced microglial expression of iNOS . Negative_regulation IL1B NAB2 19812204 2154341 , but not sodium formate , was found to *inhibit* LPS induced expression of inducible NO synthase (iNOS) , proinflammatory cytokines ( TNF-alpha and [IL-1beta] ) and surface markers ( CD11b , CD11c , and CD68 ) in mouse microglia . Negative_regulation IL1B NAB2 19812204 2154349 Similarly , also *inhibited* fibrillar amyloid beta ( Abeta ) - , prion peptide- , double stranded RNA ( polyinosinic-polycytidylic acid ) - , HIV-1 Tat- , 1-methyl-4-phenylpyridinium ( + ) - , [IL-1beta-] , and IL-12 p40 ( 2 ) -induced microglial expression of iNOS . Negative_regulation IL1B NAGLU 16465047 1548116 The presence of also *reduced* the increased blood level of [IL-1beta] ( -47 % , p < 0.02 ) and MCP-1 ( -36 % , p < 0.02 ) . Negative_regulation IL1B NAPA 9389730 467212 In addition to iNOS , lovastatin and also *inhibited* LPS induced expression of TNF-alpha , [IL-1beta] , and IL-6 in rat primary astrocytes , microglia , and macrophages . Negative_regulation IL1B NCL 19060367 2000030 [ *Role* of cell-surface in lipopolysaccharide stimulated expression and secretion of TNF-alpha and [IL-1beta] ] . Negative_regulation IL1B NCL 19060367 2000036 To explore the *role* of cell-surface in lipopolysaccharide (LPS) stimulated expression and secretion of TNF-alpha and [IL-1beta] in human THP-1 monocytes . Negative_regulation IL1B NFKB1 12021045 942763 In this study , we investigated the possible *role* of the in [IL-1beta] signaling , leading to the expression of COX-2 in human amnion cell culture . Negative_regulation IL1B NFKB1 12349954 992884 Catalposide , the major iridoid glycoside isolated from the stem bark of Catalpa ovata G. Don ( Bignoniaceae ) , was found to *inhibit* the productions of tumor necrosis factor-alpha (TNF-alpha) , [interleukin-1beta (IL-1beta)] , and interleukin-6 (IL-6) , and the activation of in RAW 264.7 macrophages activated with lipopolysaccharide (LPS) . Negative_regulation IL1B NFKB1 12898518 1118504 Our results suggest that activation in PIMs followed by phagocytizing lipopolysaccharide *resulted* in the up-regulation of TNF-alpha , [IL-1beta] , IL-6 , IL-8 , and COX-2 , which could be alleviated by dexamethasone . Negative_regulation IL1B NFKB1 14503852 1144635 Astaxanthin also suppressed the serum levels of NO , PGE2 , TNF-alpha , and [IL-1beta] in LPS administrated mice , and *inhibited* activation as well as iNOS promoter activity in RAW264.7 cells stimulated with LPS . Negative_regulation IL1B NFKB1 17115116 1709114 Resveratrol , a polyphenolic , natural phytoalexin found with particularly high levels in grape skin and red wine is potent and specific inhibitor of TNF-alpha and [IL-1beta] *induced* activation . Negative_regulation IL1B NFKB1 17931811 1819688 In lipopolysaccharide (LPS) stimulated RAW264.7 cells , HMCO5 inhibited activation as well as iNOS promoter activity , *inhibited* the secretion of TNF-alpha and [IL-1beta] , and directly inhibited the intracellular accumulation of reactive oxygen species . Negative_regulation IL1B NFKB1 18669445 1973086 DPML significantly inhibited tumor necrosis factor alpha , [interleukin-1beta] , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* and p38 mitogen activated protein kinase activation in the lung . Negative_regulation IL1B NFKB1 19616538 2124177 Ghrelin also significantly suppressed [interleukin-1beta] , tumor necrosis factor-alpha , and endothelin-l mRNA expression , and *inhibited* activation . Negative_regulation IL1B NFKB1 19748795 2153104 ZD 7155 also reduced the mRNA expression of TNF-alpha and [IL-1 beta] , *inhibited* the activation of and AP-1 , and improved lung histopathology . Negative_regulation IL1B NFKB1 9079634 420540 *Role* of in tumor necrosis factor-alpha and [interleukin-1beta] regulation . Negative_regulation IL1B NFKB1 9510209 491885 The *role* of activation in BK-induced [IL-1beta] synthesis was demonstrated by the ability of BK to stimulate increased chloramphenicol acetyltransferase (CAT) activity in A549 cells transfected with a reporter plasmid containing three kappaB enhancers from the IL-1beta gene , while deletion of the kappaB enhancer sequences eliminated BK-stimulated CAT activity . Negative_regulation IL1B NFKB1 9510209 491891 C3 transferase exoenzyme , an inhibitor of Rho , abolished BK-induced activation at 10 microg/ml and significantly *inhibited* BK-stimulated [IL-1beta] synthesis at 5 microg/ml . Negative_regulation IL1B NFKBIA 15723090 1396077 Similarly , IKK beta ( KA ) and delta N overexpression also *inhibited* [IL-1beta-] and TNF alpha dependent increases in ICAM-1 , IL-8 and GM-CSF in addition to IL-1beta mediated increases in cyclooxygenase-2 expression , whereas IKK alpha ( KM ) overexpression had little effect on these outputs . Negative_regulation IL1B NFKBIA 19032979 2022945 To elucidate potential molecular mechanisms of SCYA2 increase , we examined genes in the nuclear factor-kappa B (NF-kappaB) signaling cascade including tumor necrosis factor-alpha (TNF-alpha) , [interleukin-1beta (IL-1beta)] and *inhibitor* of kappa B alpha ( ) in choroid tissue . Negative_regulation IL1B NLRC4 19120480 2019401 In this review , we focus on the role of Nod1 and Nod2 in host defense and in particular discuss recent finding regarding the *role* of , Nlpr1 , and Nlrp3 inflammasomes in caspase-1 activation and subsequent release of proinflammatory cytokines such as [interleukin-1 beta] . Negative_regulation IL1B NLRP3 14634131 1170917 We also show that expression of the PAAD/PYRIN family proteins pyrin or individually inhibits IL-1beta secretion but that coexpression of ASC with these proteins *results* in enhanced [IL-1beta] secretion . Negative_regulation IL1B NLRP3 15020601 1243437 The induction of activity by enforced oligomerization in THP-1 cells *resulted* in ASC binding and the secretion of [IL-1beta] , an effect that was abolished by the inhibition of ASC expression with small interfering RNAs . Negative_regulation IL1B NOD1 20393137 2262208 Interestingly , the of human PYNOD was *sufficient* to inhibit caspase-1 mediated [IL-1beta] secretion , whereas its pyrin domain was sufficient to inhibit ASC mediated NF-kappaB activation and apoptosis and to reduce ASC 's ability to promote caspase-1 mediated IL-1beta production . Negative_regulation IL1B NOD2 20393137 2262209 Interestingly , the of human PYNOD was sufficient to *inhibit* caspase-1 mediated [IL-1beta] secretion , whereas its pyrin domain was sufficient to inhibit ASC mediated NF-kappaB activation and apoptosis and to reduce ASC 's ability to promote caspase-1 mediated IL-1beta production . Negative_regulation IL1B NOS1 11850061 912933 Inhibition of the inducible form of ( iNOS ) by L-NIL did not affect LPS toxicity , but *increased* the LPS induced levels of both TNF-alpha and [IL-1beta] . Negative_regulation IL1B NOS1 9299361 453441 Simultaneous incubation with [IL-1beta] in the *presence* of the inhibitor NG-monomethyl-l-arginine or the RNA synthesis inhibitor actinomycin D for 24 h completely inhibited ANP- and BNP- as well as IL-1beta induced nitrite production . Negative_regulation IL1B NOS2 10577516 569528 When mouse peritoneal exudate cells ( PEC ) or RAW 264.7 cells were stimulated with lipopolysaccharide (LPS) , concomitant inhibition of *resulted* in an increase of [IL-1beta] and IL-1alpha protein secretion . Negative_regulation IL1B NOS2 11850061 912934 Inhibition of the inducible form of ( iNOS ) by L-NIL did not affect LPS toxicity , but *increased* the LPS induced levels of both TNF-alpha and [IL-1beta] . Negative_regulation IL1B NOS2 12823994 1104345 Cultured immortalized rabbit lacrimal gland acinar cells were incubated with [IL-1beta] , *inhibitor* , or IL-1 receptor antagonist (IL-1ra) . Negative_regulation IL1B NOS2 14503852 1144636 Astaxanthin also suppressed the serum levels of NO , PGE2 , TNF-alpha , and [IL-1beta] in LPS administrated mice , and *inhibited* NF-kappaB activation as well as promoter activity in RAW264.7 cells stimulated with LPS . Negative_regulation IL1B NOS2 16211305 1464586 Neither extract affected TNFalpha and mRNA expression in LPS stimulated cells , but at a 1/100 dilution they both *reduced* [IL-1beta] mRNA expression in LPS stimulated cells ( p < 0.01 ) . Negative_regulation IL1B NOS2 17931811 1819689 In lipopolysaccharide (LPS) stimulated RAW264.7 cells , HMCO5 inhibited NF-kappaB activation as well as promoter activity , *inhibited* the secretion of TNF-alpha and [IL-1beta] , and directly inhibited the intracellular accumulation of reactive oxygen species . Negative_regulation IL1B NOS2 20712904 2317877 Resveratrol inhibited LPS induced expression and release of TNF-alpha , IL-6 , MCP-1 , and in both cell types with more potency in microglia , and *inhibited* LPS induced expression of [IL-1beta] in microglia but not astrocytes . Negative_regulation IL1B NOS3 11850061 912935 Inhibition of the inducible form of ( iNOS ) by L-NIL did not affect LPS toxicity , but *increased* the LPS induced levels of both TNF-alpha and [IL-1beta] . Negative_regulation IL1B NOX1 15390122 1304812 Expression of [IL-1beta] , TNF-alpha , and iNOS in ganglioside treated cells was significantly *reduced* in the presence of inhibitors of PKC ( GF109203X , Go6976 , Ro31-8220 , and rottlerin ) and ( diphenyleneiodonium chloride [ DPI ] ) . Negative_regulation IL1B NOX3 15390122 1304813 Expression of [IL-1beta] , TNF-alpha , and iNOS in ganglioside treated cells was significantly reduced in the *presence* of inhibitors of PKC ( GF109203X , Go6976 , Ro31-8220 , and rottlerin ) and ( diphenyleneiodonium chloride [ DPI ] ) . Negative_regulation IL1B NOX4 15390122 1304814 Expression of [IL-1beta] , TNF-alpha , and iNOS in ganglioside treated cells was significantly *reduced* in the presence of inhibitors of PKC ( GF109203X , Go6976 , Ro31-8220 , and rottlerin ) and ( diphenyleneiodonium chloride [ DPI ] ) . Negative_regulation IL1B NOX5 15390122 1304811 Expression of [IL-1beta] , TNF-alpha , and iNOS in ganglioside treated cells was significantly *reduced* in the presence of inhibitors of PKC ( GF109203X , Go6976 , Ro31-8220 , and rottlerin ) and ( diphenyleneiodonium chloride [ DPI ] ) . Negative_regulation IL1B NPPA 10861050 705138 significantly *attenuated* production of TNF-alpha and [IL-1beta] without affecting production of IL-10 and IL-1ra . Negative_regulation IL1B NPY4R 15117678 1279444 Expression of [IL-1beta] , IL-6 , IL-8 , and COX-2 mRNA was *reduced* by 30 microM , an Src family tyrosine kinase inhibitor , and by 25 microM SB-203580 , a p38 MAPK inhibitor . Negative_regulation IL1B NR3C1 19281808 2063745 Moreover , pharmacological inhibition of function by its antagonist ( RU486 ) *inhibited* pioglitazone mediated downregulation of TNF-alpha and [IL-1beta] gene expression confirming involvement of glucocorticoid receptor in pioglitazone mediated ulcer healing . Negative_regulation IL1B NUP43 17395477 1728127 In the present study the quantitative *role* of and p38 in the production of TNF-alpha , [IL-1beta] and IL-12 by murine peritoneal macrophages , in vitro , on treatment with Concanavalin A ( ConA ) has been investigated . Negative_regulation IL1B P2RX7 15883745 1406649 Activation of receptors on RPC *resulted* in [IL-1 beta] secretion , which was inhibited by PPADS . Negative_regulation IL1B P2RX7 17121814 1686337 Blockade of pannexin-1 in macrophage endogenously expressing the ATP gated P2X7 receptor (P2X7R) blocks the initial dye uptake , but not the ionic current , and also blocks processing and release of [interleukin-1beta (IL-1beta)] in *response* to activation . Negative_regulation IL1B P2RX7 17351655 1727215 Activation of *resulted* in low-level release of bioactive [IL-1beta] and simultaneous release of IL-1Ra . Negative_regulation IL1B P2RX7 17491021 1761574 However , the *roles* of receptor and intracellular K ( + ) in [IL-1beta] secretion induced by bacterial infection remain unknown . Negative_regulation IL1B P2RX7 17905568 1843821 In vitro and in vivo evidence for a *role* of the receptor in the release of [IL-1 beta] in the murine brain . Negative_regulation IL1B P2RX7 18384650 1925531 Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury : a crucial role of receptor *mediated* [IL-1beta] release . Negative_regulation IL1B P2RX7 18996151 2022160 Activation of receptors *results* in the rapid release of [interleukin-1 beta (IL-1 beta)] . Negative_regulation IL1B PANX1 19212823 2079417 Inhibition of *blocks* P2X(7)R mediated [IL-1beta] release from macrophage as well as release mediated by other stimuli which couple to activation of capase-1 and additionally inhibits the release of interleukin-1alpha , a member of the IL-1 family whose processing does not require caspase-1 activation . Negative_regulation IL1B PARP1 19765544 2147396 Minocycline repressed the expression of TNF-alpha , [IL-1beta] , and iNOS , decreased the apoptotic index , and *inhibited* ( PARP-1 ) activity in the mouse small intestine . Negative_regulation IL1B PDGFB 1936271 170272 dose-dependently *suppressed* the [IL-1 beta-] and forskolin induced elevation of PLA2 mRNA , as well as PLA2 synthesis and secretion . Negative_regulation IL1B PDGFB 9555020 499667 potently *inhibits* secretion of [IL-1beta-] and forskolin induced group II PLA2 activity . Negative_regulation IL1B PI3 15597323 1361721 Finally , inhibition of dramatically *enhanced* the [IL-1 beta] response to anti-CD33 and neuraminidase , while inhibition of p38 mitogen activated protein kinase (MAPK) abolished it . Negative_regulation IL1B PI3 17182583 1679846 The present results demonstrate that are *involved* in the inhibition of [IL-1beta] secretion and in the induction of sIL-1Ra production in human blood monocytes by controlling different mechanisms in conditions mimicking chronic/sterile ( CE ( sHUT ) ) and acute/infectious ( LPS ) inflammation . Negative_regulation IL1B PIK3CA 14688354 1190710 Inhibition of *resulted* in increased serum levels of [IL1-beta] , IL-2 , IL-6 , IL-10 , IL-12 , and TNF-alpha in septic mice . Negative_regulation IL1B PIK3CA 15665520 1365594 The study shows that but not MAPKK-1 inhibition resulted in the *loss* of hypoxic and [IL-1beta] induced HIF-1alpha accumulation , whereas VEGF synthesis was reduced by either intervention . Negative_regulation IL1B PIK3CA 17182583 1679843 In contrast , inhibition *increased* the production of [IL-1beta] protein in both CE ( sHUT ) - and LPS activated monocytes , the enhancement being drastically higher in the former . Negative_regulation IL1B PIK3CA 17442978 1729723 In addition , inhibition *resulted* in strongly elevated TLR-4 mediated generation of [IL-1beta] and IL-8 in neutrophils when these cells were co-stimulated with C5a . Negative_regulation IL1B PIK3CA 19258518 2079637 The inhibitor LY294002 [ 2- ( 4-morpholinyl ) -8-phenyl-1 ( 4H ) -benzopyran-4-one hydrochloride ] abolished the H ( 2 ) S-mediated activation of AKT and *increases* tumor necrosis factor alpha and [interleukin 1beta] levels in caerulein treated acinar cells . Negative_regulation IL1B PIK3R1 14688354 1190711 Inhibition of *resulted* in increased serum levels of [IL1-beta] , IL-2 , IL-6 , IL-10 , IL-12 , and TNF-alpha in septic mice . Negative_regulation IL1B PIK3R1 15665520 1365595 The study shows that but not MAPKK-1 inhibition *resulted* in the loss of hypoxic and [IL-1beta] induced HIF-1alpha accumulation , whereas VEGF synthesis was reduced by either intervention . Negative_regulation IL1B PIK3R1 17182583 1679844 In contrast , inhibition *increased* the production of [IL-1beta] protein in both CE ( sHUT ) - and LPS activated monocytes , the enhancement being drastically higher in the former . Negative_regulation IL1B PIK3R1 17442978 1729724 In addition , inhibition *resulted* in strongly elevated TLR-4 mediated generation of [IL-1beta] and IL-8 in neutrophils when these cells were co-stimulated with C5a . Negative_regulation IL1B PIK3R1 19258518 2079638 The inhibitor LY294002 [ 2- ( 4-morpholinyl ) -8-phenyl-1 ( 4H ) -benzopyran-4-one hydrochloride ] abolished the H ( 2 ) S-mediated activation of AKT and *increases* tumor necrosis factor alpha and [interleukin 1beta] levels in caerulein treated acinar cells . Negative_regulation IL1B PIM3 20039932 2200464 Furthermore , exogenous significantly *inhibited* expression of tumour necrosis factor-alpha and [interleukin-1beta] in the liver , declined p53 and inducible nitric oxide synthase mRNAs levels , but elevated levels of Bcl-2 protein , an anti-apoptosis member of Bcl-2 family , in the liver . Negative_regulation IL1B PLA2G1B 11930237 927345 The experiments were carried out to explore the interactions between [IL-1 beta] gene expression , protein level and PLA(2) *inhibition* after intestinal ischemia/reperfusion injury . Negative_regulation IL1B PLA2G1B 1568479 186948 The glucocorticoid dexamethasone only partially suppressed the [IL-1 beta-] and forskolin induced elevation of PLA2 mRNA , but totally *inhibited* synthesis and secretion . Negative_regulation IL1B PLA2G1B 8832976 385869 The *role* of the cytosolic 85 kDa in [IL-1beta] induced human rheumatoid synovial fibroblast PGE2 formation was directly evaluated using an antisense phosphorothioate oligonucleotide to the initiation site of the 85 kDa PLA2 mRNA . Negative_regulation IL1B PLAU 10892857 711302 Both [IL-1beta] and TNF-alpha *induced* a significant decrease in expression in PBF , whereas bFGF induced a slight increase in both HJF and PBF . Negative_regulation IL1B PLG 20152938 2227598 Treatment with RS504393 had a noteworthy preventative effect on LPS induced over-expression of [IL-1beta] , activator *inhibitor* and CCR2 . Negative_regulation IL1B PPARA 18710415 1979750 Importantly , increased activity *attenuated* induction of [IL-1beta] , tumor necrosis factor-alpha , CCL2 , and E-selectin in hCMEC/D3 cells co-cultured with HIV-1 infected Jurkat cells . Negative_regulation IL1B PPARG 17235413 1664229 The expressions of [IL-1beta] , IL-6 , ANP , and BNP were significantly *enhanced* , whereas that of was significantly reduced in Ang II-induced hypertrophic cardiomyocytes . Negative_regulation IL1B PPARG 17521952 1751280 Activation of by PPAR-gamma ligands or Ad-PPAR-gamma *inhibited* [IL-1 beta] and IFN-gamma stimulated nuclear translocation of the p65 subunit and DNA binding activity . Negative_regulation IL1B PRDX2 18226559 1919136 *suppressed* [interleukin 1-beta] and tumor necrosis factor-alpha stimulated up-regulation of MMP-3 , but not MMP-13 mRNA expression by ATDC5 . Negative_regulation IL1B PRG2 12096231 960884 Both PBMC and [IL-1beta] plus TNF-alpha *induced* strong inhibition of cartilage synthesis and significant enhancement of the release of proteoglycans , diminishing proteoglycan content . Negative_regulation IL1B PRG3 12096231 960885 Both PBMC and [IL-1beta] plus TNF-alpha *induced* strong inhibition of cartilage synthesis and significant enhancement of the release of proteoglycans , diminishing proteoglycan content . Negative_regulation IL1B PRG4 12096231 960886 Both PBMC and [IL-1beta] plus TNF-alpha *induced* strong inhibition of cartilage synthesis and significant enhancement of the release of proteoglycans , diminishing proteoglycan content . Negative_regulation IL1B PRKAA1 14724246 1198055 A pharmacological activator of , 5-amino-4-imidazole carboxamide riboside ( AICAR ) *inhibited* lipopolysaccharide (LPS) induced expression of proinflammatory cytokines ( tumor necrosis factor alpha , [interleukin-1beta] , and interleukin-6 ) and inducible nitric oxide synthase in primary rat astrocytes , microglia , and peritoneal macrophages . Negative_regulation IL1B PRKAA1 17717055 1807521 In parallel , the pharmacological activation of hypothalamic in TB animals markedly *reduced* the hypothalamic production of inducible nitric oxide synthase , [IL-1beta] , and TNF-alpha and modulated the expression of proopiomelanocortin , a hypothalamic neuropeptide that is involved in the control of energy homeostasis . Negative_regulation IL1B PRKAA2 14724246 1198056 A pharmacological activator of , 5-amino-4-imidazole carboxamide riboside ( AICAR ) *inhibited* lipopolysaccharide (LPS) induced expression of proinflammatory cytokines ( tumor necrosis factor alpha , [interleukin-1beta] , and interleukin-6 ) and inducible nitric oxide synthase in primary rat astrocytes , microglia , and peritoneal macrophages . Negative_regulation IL1B PRKAA2 17717055 1807522 In parallel , the pharmacological activation of hypothalamic in TB animals markedly *reduced* the hypothalamic production of inducible nitric oxide synthase , [IL-1beta] , and TNF-alpha and modulated the expression of proopiomelanocortin , a hypothalamic neuropeptide that is involved in the control of energy homeostasis . Negative_regulation IL1B PRKAB1 14724246 1198057 A pharmacological activator of , 5-amino-4-imidazole carboxamide riboside ( AICAR ) *inhibited* lipopolysaccharide (LPS) induced expression of proinflammatory cytokines ( tumor necrosis factor alpha , [interleukin-1beta] , and interleukin-6 ) and inducible nitric oxide synthase in primary rat astrocytes , microglia , and peritoneal macrophages . Negative_regulation IL1B PRKAB1 17717055 1807523 In parallel , the pharmacological activation of hypothalamic in TB animals markedly *reduced* the hypothalamic production of inducible nitric oxide synthase , [IL-1beta] , and TNF-alpha and modulated the expression of proopiomelanocortin , a hypothalamic neuropeptide that is involved in the control of energy homeostasis . Negative_regulation IL1B PRKAB2 14724246 1198058 A pharmacological activator of , 5-amino-4-imidazole carboxamide riboside ( AICAR ) *inhibited* lipopolysaccharide (LPS) induced expression of proinflammatory cytokines ( tumor necrosis factor alpha , [interleukin-1beta] , and interleukin-6 ) and inducible nitric oxide synthase in primary rat astrocytes , microglia , and peritoneal macrophages . Negative_regulation IL1B PRKAB2 17717055 1807524 In parallel , the pharmacological activation of hypothalamic in TB animals markedly *reduced* the hypothalamic production of inducible nitric oxide synthase , [IL-1beta] , and TNF-alpha and modulated the expression of proopiomelanocortin , a hypothalamic neuropeptide that is involved in the control of energy homeostasis . Negative_regulation IL1B PRKACB 17505309 1744661 CCK-8 *inhibits* LPS induced [IL-1beta] production in pulmonary interstitial macrophages by modulating , p38 , and NF-kappaB pathway . Negative_regulation IL1B PRKACB 17510469 1761933 In addition , inhibitors of adenylyl cyclase and *restored* [IL-1beta] signaling in apoE treated VSMCs , whereas apoE stimulated PKA activity . Negative_regulation IL1B PRKACB 19481766 2208733 Overexpression of *increased* [IL-1beta] plus IFNgamma induced NF-kappaB binding . Negative_regulation IL1B PRKACB 8872964 389796 Unexpectedly , the inhibitory action of PKA was not through cAMP response element ( CRE ) but through TRE , because ( i ) activation of CRE was not induced by [IL-1 beta] , and ( ii ) cAMP mediated activation of *suppressed* the basal TRE activity . Negative_regulation IL1B PRKACG 17505309 1744662 CCK-8 *inhibits* LPS induced [IL-1beta] production in pulmonary interstitial macrophages by modulating , p38 , and NF-kappaB pathway . Negative_regulation IL1B PRKACG 17510469 1761934 In addition , inhibitors of adenylyl cyclase and *restored* [IL-1beta] signaling in apoE treated VSMCs , whereas apoE stimulated PKA activity . Negative_regulation IL1B PRKACG 19481766 2208734 Overexpression of *increased* [IL-1beta] plus IFNgamma induced NF-kappaB binding . Negative_regulation IL1B PRKACG 8872964 389797 Unexpectedly , the inhibitory action of PKA was not through cAMP response element ( CRE ) but through TRE , because ( i ) activation of CRE was not induced by [IL-1 beta] , and ( ii ) cAMP mediated activation of *suppressed* the basal TRE activity . Negative_regulation IL1B PRKAG1 14724246 1198059 A pharmacological activator of , 5-amino-4-imidazole carboxamide riboside ( AICAR ) *inhibited* lipopolysaccharide (LPS) induced expression of proinflammatory cytokines ( tumor necrosis factor alpha , [interleukin-1beta] , and interleukin-6 ) and inducible nitric oxide synthase in primary rat astrocytes , microglia , and peritoneal macrophages . Negative_regulation IL1B PRKAG1 17717055 1807525 In parallel , the pharmacological activation of hypothalamic in TB animals markedly *reduced* the hypothalamic production of inducible nitric oxide synthase , [IL-1beta] , and TNF-alpha and modulated the expression of proopiomelanocortin , a hypothalamic neuropeptide that is involved in the control of energy homeostasis . Negative_regulation IL1B PRKAG2 14724246 1198060 A pharmacological activator of , 5-amino-4-imidazole carboxamide riboside ( AICAR ) *inhibited* lipopolysaccharide (LPS) induced expression of proinflammatory cytokines ( tumor necrosis factor alpha , [interleukin-1beta] , and interleukin-6 ) and inducible nitric oxide synthase in primary rat astrocytes , microglia , and peritoneal macrophages . Negative_regulation IL1B PRKAG2 17717055 1807526 In parallel , the pharmacological activation of hypothalamic in TB animals markedly *reduced* the hypothalamic production of inducible nitric oxide synthase , [IL-1beta] , and TNF-alpha and modulated the expression of proopiomelanocortin , a hypothalamic neuropeptide that is involved in the control of energy homeostasis . Negative_regulation IL1B PRKAR1A 17505309 1744663 CCK-8 *inhibits* LPS induced [IL-1beta] production in pulmonary interstitial macrophages by modulating , p38 , and NF-kappaB pathway . Negative_regulation IL1B PRKAR1A 17510469 1761935 In addition , inhibitors of adenylyl cyclase and *restored* [IL-1beta] signaling in apoE treated VSMCs , whereas apoE stimulated PKA activity . Negative_regulation IL1B PRKAR1A 19481766 2208735 Overexpression of *increased* [IL-1beta] plus IFNgamma induced NF-kappaB binding . Negative_regulation IL1B PRKAR1A 8872964 389798 Unexpectedly , the inhibitory action of PKA was not through cAMP response element ( CRE ) but through TRE , because ( i ) activation of CRE was not induced by [IL-1 beta] , and ( ii ) cAMP mediated activation of *suppressed* the basal TRE activity . Negative_regulation IL1B PRKAR1B 17505309 1744664 CCK-8 *inhibits* LPS induced [IL-1beta] production in pulmonary interstitial macrophages by modulating , p38 , and NF-kappaB pathway . Negative_regulation IL1B PRKAR1B 17510469 1761936 In addition , inhibitors of adenylyl cyclase and *restored* [IL-1beta] signaling in apoE treated VSMCs , whereas apoE stimulated PKA activity . Negative_regulation IL1B PRKAR1B 19481766 2208736 Overexpression of *increased* [IL-1beta] plus IFNgamma induced NF-kappaB binding . Negative_regulation IL1B PRKAR1B 8872964 389799 Unexpectedly , the inhibitory action of PKA was not through cAMP response element ( CRE ) but through TRE , because ( i ) activation of CRE was not induced by [IL-1 beta] , and ( ii ) cAMP mediated activation of *suppressed* the basal TRE activity . Negative_regulation IL1B PRKAR2A 17505309 1744665 CCK-8 *inhibits* LPS induced [IL-1beta] production in pulmonary interstitial macrophages by modulating , p38 , and NF-kappaB pathway . Negative_regulation IL1B PRKAR2A 17510469 1761937 In addition , inhibitors of adenylyl cyclase and *restored* [IL-1beta] signaling in apoE treated VSMCs , whereas apoE stimulated PKA activity . Negative_regulation IL1B PRKAR2A 19481766 2208737 Overexpression of *increased* [IL-1beta] plus IFNgamma induced NF-kappaB binding . Negative_regulation IL1B PRKAR2A 8872964 389800 Unexpectedly , the inhibitory action of PKA was not through cAMP response element ( CRE ) but through TRE , because ( i ) activation of CRE was not induced by [IL-1 beta] , and ( ii ) cAMP mediated activation of *suppressed* the basal TRE activity . Negative_regulation IL1B PRKAR2B 17505309 1744666 CCK-8 *inhibits* LPS induced [IL-1beta] production in pulmonary interstitial macrophages by modulating , p38 , and NF-kappaB pathway . Negative_regulation IL1B PRKAR2B 17510469 1761938 In addition , inhibitors of adenylyl cyclase and *restored* [IL-1beta] signaling in apoE treated VSMCs , whereas apoE stimulated PKA activity . Negative_regulation IL1B PRKAR2B 19481766 2208738 Overexpression of *increased* [IL-1beta] plus IFNgamma induced NF-kappaB binding . Negative_regulation IL1B PRKAR2B 8872964 389801 Unexpectedly , the inhibitory action of PKA was not through cAMP response element ( CRE ) but through TRE , because ( i ) activation of CRE was not induced by [IL-1 beta] , and ( ii ) cAMP mediated activation of *suppressed* the basal TRE activity . Negative_regulation IL1B PRSS8 16638913 1589714 LPS induction of COX-2 , TNF-alpha , [IL-1beta] , and IL-6 expression , however , was not *reduced* by transgene expression . Negative_regulation IL1B PTGS2 10433392 633997 This greater ability from the older rGF cells to produce PGE2 and [IL-1beta] was *due* to higher mRNA levels of and IL-1beta , respectively . Negative_regulation IL1B PTGS2 10924071 718165 These findings indicate that : 1 ) PMA , acting through PKC and p38 kinase , enhances expression , but chronic treatment with PMA partially *inhibits* [IL-1beta] stimulation of COX-2 ; Negative_regulation IL1B PTGS2 10946846 721623 All HMG-CoA reductase inhibitors significantly reduced [interleukin-1beta] and -6 mRNA expression and their protein levels in the culture medium , and also *inhibited* mRNA expression and their protein levels . Negative_regulation IL1B PTGS2 16423868 1533939 PGE ( 2 ) and PGF ( 2alpha ) reverse mediated *inhibition* of [IL-1beta] induction of cytokine expression and PG production . Negative_regulation IL1B PTGS2 9863663 556123 *Role* of induction in [interleukin-1beta] induced attenuation of cultured human airway smooth muscle cell cyclic AMP generation in response to isoprenaline . Negative_regulation IL1B PTGS2 9863663 556127 We investigated the *role* of induction and prostanoid release ( measured as PGE2 ) in [IL-1beta] induced attenuation of cyclic AMP generation in response to the beta-adrenoceptor agonist isoprenaline ( ISO ) . Negative_regulation IL1B PTK2 11775830 766390 *Role* of in [IL-1 beta] induced activation of mitogen activated protein kinase in fibroblast-like synoviocytes of rheumatoid arthritis . Negative_regulation IL1B PTK6 11775830 766391 *Role* of in [IL-1 beta] induced activation of mitogen activated protein kinase in fibroblast-like synoviocytes of rheumatoid arthritis . Negative_regulation IL1B PTK7 11775830 766392 *Role* of in [IL-1 beta] induced activation of mitogen activated protein kinase in fibroblast-like synoviocytes of rheumatoid arthritis . Negative_regulation IL1B PTX3 1596574 188751 DEX and *reduced* the acivicin induced increases in TNF-alpha and [IL-1 beta] mRNA expression , but they had little or no effect on the acivicin induced decreases in expression of mRNA for c-myc and c-myb . Negative_regulation IL1B PTX3 1596574 188755 Thus , DEX and effectively *block* the acivicin induced expression of TNF-alpha and [IL-1 beta] , but they have little influence on the acivicin induced differentiation process . Negative_regulation IL1B PTX4 1596574 188750 DEX and *reduced* the acivicin induced increases in TNF-alpha and [IL-1 beta] mRNA expression , but they had little or no effect on the acivicin induced decreases in expression of mRNA for c-myc and c-myb . Negative_regulation IL1B PTX4 1596574 188754 Thus , DEX and effectively *block* the acivicin induced expression of TNF-alpha and [IL-1 beta] , but they have little influence on the acivicin induced differentiation process . Negative_regulation IL1B RAC1 15060067 1251508 Targeting by the Yersinia effector protein YopE *inhibits* caspase-1 mediated maturation and release of [interleukin-1beta] . Negative_regulation IL1B RAC1 18684863 1973563 Importantly , inhibition of in peripheral blood mononuclear cells isolated from MKD patients *resulted* in a dramatic reduction in [IL-1beta] release . Negative_regulation IL1B RAD1 14967193 1209127 Dex , but not , *inhibited* [IL-1beta] expression . Negative_regulation IL1B RAD17 14967193 1209128 Dex , but not , *inhibited* [IL-1beta] expression . Negative_regulation IL1B RAD18 14967193 1209126 Dex , but not , *inhibited* [IL-1beta] expression . Negative_regulation IL1B RAD21 14967193 1209129 Dex , but not , *inhibited* [IL-1beta] expression . Negative_regulation IL1B RAD50 14967193 1209130 Dex , but not , *inhibited* [IL-1beta] expression . Negative_regulation IL1B RAD51 14967193 1209131 Dex , but not , *inhibited* [IL-1beta] expression . Negative_regulation IL1B RAD52 14967193 1209132 Dex , but not , *inhibited* [IL-1beta] expression . Negative_regulation IL1B RBBP4 19107653 2018857 Human articular chondrocyte cultures were treated with FGF2 or [IL-1beta] in the *presence* or absence of inhibitor ( trichostatin A , TSA ) . Negative_regulation IL1B RBBP7 19107653 2018858 Human articular chondrocyte cultures were treated with FGF2 or [IL-1beta] in the *presence* or absence of inhibitor ( trichostatin A , TSA ) . Negative_regulation IL1B RELA 12021045 942764 In this study , we investigated the possible *role* of the in [IL-1beta] signaling , leading to the expression of COX-2 in human amnion cell culture . Negative_regulation IL1B RELA 12349954 992885 Catalposide , the major iridoid glycoside isolated from the stem bark of Catalpa ovata G. Don ( Bignoniaceae ) , was found to *inhibit* the productions of tumor necrosis factor-alpha (TNF-alpha) , [interleukin-1beta (IL-1beta)] , and interleukin-6 (IL-6) , and the activation of in RAW 264.7 macrophages activated with lipopolysaccharide (LPS) . Negative_regulation IL1B RELA 12898518 1118505 Our results suggest that activation in PIMs followed by phagocytizing lipopolysaccharide *resulted* in the up-regulation of TNF-alpha , [IL-1beta] , IL-6 , IL-8 , and COX-2 , which could be alleviated by dexamethasone . Negative_regulation IL1B RELA 14503852 1144637 Astaxanthin also suppressed the serum levels of NO , PGE2 , TNF-alpha , and [IL-1beta] in LPS administrated mice , and *inhibited* activation as well as iNOS promoter activity in RAW264.7 cells stimulated with LPS . Negative_regulation IL1B RELA 17115116 1709115 Resveratrol , a polyphenolic , natural phytoalexin found with particularly high levels in grape skin and red wine is potent and specific inhibitor of TNF-alpha and [IL-1beta] *induced* activation . Negative_regulation IL1B RELA 17931811 1819690 In lipopolysaccharide (LPS) stimulated RAW264.7 cells , HMCO5 inhibited activation as well as iNOS promoter activity , *inhibited* the secretion of TNF-alpha and [IL-1beta] , and directly inhibited the intracellular accumulation of reactive oxygen species . Negative_regulation IL1B RELA 18669445 1973087 DPML significantly inhibited tumor necrosis factor alpha , [interleukin-1beta] , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* and p38 mitogen activated protein kinase activation in the lung . Negative_regulation IL1B RELA 19616538 2124178 Ghrelin also significantly suppressed [interleukin-1beta] , tumor necrosis factor-alpha , and endothelin-l mRNA expression , and *inhibited* activation . Negative_regulation IL1B RELA 19748795 2153105 ZD 7155 also reduced the mRNA expression of TNF-alpha and [IL-1 beta] , *inhibited* the activation of and AP-1 , and improved lung histopathology . Negative_regulation IL1B RELA 9079634 420541 *Role* of in tumor necrosis factor-alpha and [interleukin-1beta] regulation . Negative_regulation IL1B RELA 9510209 491886 The *role* of activation in BK-induced [IL-1beta] synthesis was demonstrated by the ability of BK to stimulate increased chloramphenicol acetyltransferase (CAT) activity in A549 cells transfected with a reporter plasmid containing three kappaB enhancers from the IL-1beta gene , while deletion of the kappaB enhancer sequences eliminated BK-stimulated CAT activity . Negative_regulation IL1B RELA 9510209 491892 C3 transferase exoenzyme , an inhibitor of Rho , abolished BK-induced activation at 10 microg/ml and significantly *inhibited* BK-stimulated [IL-1beta] synthesis at 5 microg/ml . Negative_regulation IL1B RELB 16951372 1610596 Transient expression of *inhibited* [IL-1beta] in endotoxin-responsive cells . Negative_regulation IL1B RIT2 19781666 2159215 and IRN concentration-dependently *attenuated* LPS induced production of proinflammatory cytokines such as TNF-alpha and [IL-1beta] as well as NO in mouse N9 microglial cells , with IRN showing more potent inhibition of microglial activation . Negative_regulation IL1B RNASE3 19384158 2069174 efficiently *impairs* the spontaneous maturation and secretion of proinflammatory tumor necrosis factor-alpha , [interleukin-1beta] , and interleukin-12 by slanDCs . Negative_regulation IL1B RNF19A 17505309 1744659 CCK-8 *inhibits* LPS induced [IL-1beta] production in pulmonary interstitial macrophages by modulating PKA , , and NF-kappaB pathway . Negative_regulation IL1B RNF19A 9624172 511376 Differential *roles* of extracellular signal regulated kinase-1/2 and ( MAPK ) in [interleukin-1beta-] and tumor necrosis factor-alpha induced low density lipoprotein receptor expression in HepG2 cells . Negative_regulation IL1B RNH1 15879491 1439791 In vitro study showed that both olmesartan and its active metabolite *suppressed* [IL-1beta] production in U-937 cells and cultured myocytes . Negative_regulation IL1B RP1 19145554 2048111 Ginsenoside , a ginsenoside derivative , *blocks* lipopolysaccharide induced [interleukin-1beta] production via suppression of the NF-kappaB pathway . Negative_regulation IL1B S100A12 19299480 2106071 In the present study , we demonstrate that is *involved* in morphine tolerance by differentially regulating the ERK dependent up-regulation of [IL-1beta] , TNF-alpha , and microsomal prostaglandin E synthase-1 ( mPGES-1 ) in astrocytes and p38 dependent up-regulation of IL-6 in microglia in the rat spinal cord . Negative_regulation IL1B SEA 19812189 2154330 *suppressed* the LPS induced DCs production of [IL-1beta] , IL-6 , IL-12 , and TNF-alpha and enhanced TGF-beta as well as IL-10 production . Negative_regulation IL1B SERPINA4 20377366 2181283 gene transfer *reduced* the levels of [interleukin-1beta] and tumor necrosis factor-alpha in joints . Negative_regulation IL1B SETD2 16504308 1549058 Similarly , binding `` decoy '' oligonuleotide transfected into astrocytes *inhibited* both hypoxia induced transactivation of the HIF-1 reporter gene and [IL-1beta] secretion from transfected astrocytes . Negative_regulation IL1B SH3D19 8635505 362068 Immunohistochemistry showed that EBP and IL-1 receptor type I codistributed on surfaces of unstimulated coronary artery SMC , while CS- and kappa-El dependent removal of from the cell surface *increased* binding of radiolabeled [IL-1beta] to CA SMC . Negative_regulation IL1B SIRPA 12483539 1024777 A *role* for in [IL-1beta-] and TNFalpha dependent signaling . Negative_regulation IL1B SIRPA 12483539 1024780 We investigated the *role* of in [IL-1beta-] and TNFalpha dependent signaling that leads to the activation of Erk 1/2 and Akt . Negative_regulation IL1B SIRPA 12483539 1024807 Exogenous expression of either mutants that lack SHP-2 binding function or a dominant negative mutant of SHP-2 markedly *inhibited* the activation of Erk 1/2 and Akt by [IL-1beta] , whereas wild type SHPS-1 did not . Negative_regulation IL1B SIRPA 12483539 1024820 Moreover , [IL-1beta-stimulation] *induced* association of SHPS-1 with IL-1RAcP , a second subunit of IL-1 receptor , whereas expression of SHPS-1 mutant that lack SHP-2 binding function clearly blocked the association and tyrosine phosphorylation of endogenous . Negative_regulation IL1B SLCO6A1 8937133 398351 *inhibited* the production of [IL-1 beta] and IL-6 . Negative_regulation IL1B SMAD7 15752249 1379939 Real-time polymerase chain reaction ( PCR ) and immunohistochemistry revealed that gene transfer of resulted in a substantial *inhibition* of [interleukin-1beta (IL-1beta)] and tumor necrosis factor alpha (TNFalpha) expression ( all P < 0.01 vs. control ) . Negative_regulation IL1B SMC2 19386793 2094859 Treatment of human PA-SMCs with roflumilast N-oxide , the active metabolite of roflumilast , at concentrations up to 10 ( -6 ) M , potentiated growth *inhibition* induced by prostacyclin ( 10 ( -6 ) M ) or [interleukin-1beta] ( 10 ng x ml(-1) ) but was inactive on its own . Negative_regulation IL1B SMC2 9235962 445558 Stimulation of vascular and EC through rCD40L *resulted* in the release of biologically active [IL-1beta] , indicating processing of the native IL-1beta precursor induced by the ligand . Negative_regulation IL1B SMC3 19386793 2094863 Treatment of human PA-SMCs with roflumilast N-oxide , the active metabolite of roflumilast , at concentrations up to 10 ( -6 ) M , potentiated growth *inhibition* induced by prostacyclin ( 10 ( -6 ) M ) or [interleukin-1beta] ( 10 ng x ml(-1) ) but was inactive on its own . Negative_regulation IL1B SMC3 9235962 445562 Stimulation of vascular and EC through rCD40L *resulted* in the release of biologically active [IL-1beta] , indicating processing of the native IL-1beta precursor induced by the ligand . Negative_regulation IL1B SMC4 19386793 2094860 Treatment of human PA-SMCs with roflumilast N-oxide , the active metabolite of roflumilast , at concentrations up to 10 ( -6 ) M , potentiated growth *inhibition* induced by prostacyclin ( 10 ( -6 ) M ) or [interleukin-1beta] ( 10 ng x ml(-1) ) but was inactive on its own . Negative_regulation IL1B SMC4 9235962 445559 Stimulation of vascular and EC through rCD40L *resulted* in the release of biologically active [IL-1beta] , indicating processing of the native IL-1beta precursor induced by the ligand . Negative_regulation IL1B SMC5 19386793 2094861 Treatment of human PA-SMCs with roflumilast N-oxide , the active metabolite of roflumilast , at concentrations up to 10 ( -6 ) M , potentiated growth *inhibition* induced by prostacyclin ( 10 ( -6 ) M ) or [interleukin-1beta] ( 10 ng x ml(-1) ) but was inactive on its own . Negative_regulation IL1B SMC5 9235962 445560 Stimulation of vascular and EC through rCD40L *resulted* in the release of biologically active [IL-1beta] , indicating processing of the native IL-1beta precursor induced by the ligand . Negative_regulation IL1B SMC6 19386793 2094862 Treatment of human PA-SMCs with roflumilast N-oxide , the active metabolite of roflumilast , at concentrations up to 10 ( -6 ) M , potentiated growth *inhibition* induced by prostacyclin ( 10 ( -6 ) M ) or [interleukin-1beta] ( 10 ng x ml(-1) ) but was inactive on its own . Negative_regulation IL1B SMC6 9235962 445561 Stimulation of vascular and EC through rCD40L *resulted* in the release of biologically active [IL-1beta] , indicating processing of the native IL-1beta precursor induced by the ligand . Negative_regulation IL1B SOCS3 15578154 1344773 However , the mechanisms underlying *inhibition* of [IL-1beta] signalling and prevention against apoptosis remain unknown . Negative_regulation IL1B SOCS3 20478455 2263036 [IL-1beta] and IL-6 simultaneously *induced* IL-8 and monocyte chemoattractant protein-1 secretion in PDL cells , whereas overexpression suppressed secretion of these chemokines through inhibition of phosphorylation in downstream signaling . Negative_regulation IL1B SOD1 15612528 1348440 However , only + CAT and vitamin C *inhibited* the mRNA expression of [IL-1beta] . Negative_regulation IL1B SOD1 19561107 2104174 Not only silencing of thioredoxin , but also of the ROS scavenger *results* in inhibition of [IL-1beta] secretion . Negative_regulation IL1B SOD1 22189681 2518543 Histological , Western blot , and reverse transcription-polymerase chain reaction data demonstrated that silk fibroin peptide or alone could *suppress* elevated levels of cyclooxygenase-2 , interleukin-6 , [interleukin-1beta] , and tumor necrosis factor-alpha induced by TPA . Negative_regulation IL1B SOD1 8643629 363028 down-regulation *results* in an increase in [interleukin 1beta (IL- 1beta)] production by the cells , and cell death under these conditions can be prevented by either blocking antibodies against IL-1beta or the IL-1 receptor antagonist ( IL-1Ralpha ) . Negative_regulation IL1B SOD2 15612528 1348441 However , only + CAT and vitamin C *inhibited* the mRNA expression of [IL-1beta] . Negative_regulation IL1B SOD2 22189681 2518544 Histological , Western blot , and reverse transcription-polymerase chain reaction data demonstrated that silk fibroin peptide or alone could *suppress* elevated levels of cyclooxygenase-2 , interleukin-6 , [interleukin-1beta] , and tumor necrosis factor-alpha induced by TPA . Negative_regulation IL1B SOD3 15612528 1348442 However , only + CAT and vitamin C *inhibited* the mRNA expression of [IL-1beta] . Negative_regulation IL1B SOD3 22189681 2518545 Histological , Western blot , and reverse transcription-polymerase chain reaction data demonstrated that silk fibroin peptide or alone could *suppress* elevated levels of cyclooxygenase-2 , interleukin-6 , [interleukin-1beta] , and tumor necrosis factor-alpha induced by TPA . Negative_regulation IL1B SP1 18772363 1985851 The *role* of in [IL-1beta] and H. pylori mediated regulation of H , K-ATPase gene transcription . Negative_regulation IL1B SPESP1 19182385 2033255 We also found that *reduced* the expressions of pro-inflammatory cytokines ( IL-1alpha , [IL-1beta] , IL-8 , IL-16 , MCP-1 , MIP-1alpha and MIP-1beta ) by cultured cells treated with both ESP and FXa . Negative_regulation IL1B SPHK1 10944534 744118 Activation of endogenous SK activity by tumor necrosis factor-alpha (TNFalpha) , [interleukin-1beta] , and phorbol esters in HEK293T cells was *blocked* by expression of this inactive ( hSK ( G82D ) ) . Negative_regulation IL1B SPHK1 20036321 2200442 Suppression of by its inhibitor , N , N Dimethylsphingosine ( DMS ) , or siRNA *resulted* in decreased mRNA expression of TNF-alpha , [IL-1beta] , and iNOS and release of TNF-alpha and nitric oxide ( NO ) in LPS activated microglia . Negative_regulation IL1B SPHK2 10944534 744119 Activation of endogenous SK activity by tumor necrosis factor-alpha (TNFalpha) , [interleukin-1beta] , and phorbol esters in HEK293T cells was *blocked* by expression of this inactive ( hSK ( G82D ) ) . Negative_regulation IL1B SPI1 12061786 952910 Dual regulatory role of human cytomegalovirus immediate-early protein in [IL1B] transcription is *dependent* upon . Negative_regulation IL1B SST 10975802 729382 through its specific receptor *inhibits* spontaneous and TNF-alpha- and bacteria induced IL-8 and [IL-1 beta] secretion from intestinal epithelial cells . Negative_regulation IL1B SST 10975802 729384 Octreotide , which mainly stimulates somatostatin receptor subtypes 2 and 5 , affected the secretion of IL-8 and [IL-1beta] similarly , and the somatostatin antagonist completely *blocked* the somatostatin- and octreotide induced inhibitory effects . Negative_regulation IL1B STAT3 19299019 2064077 These results highlight the complex *role* of in cytokine production and the key role of STAT3 tyrosine phosphorylation in [IL-1beta] and IL-6 production in response to inflammation . Negative_regulation IL1B STS 14634131 1170916 We also show that expression of the PAAD/PYRIN family proteins pyrin or cryopyrin/PYPAF1/NALP3 individually inhibits IL-1beta secretion but that coexpression of with these proteins *results* in enhanced [IL-1beta] secretion . Negative_regulation IL1B STS 16547271 1537791 Distinct *roles* of TLR2 and the adaptor in [IL-1beta/IL-18] secretion in response to Listeria monocytogenes . Negative_regulation IL1B TAC1 23953566 2831832 The and IPC + TAC groups *down-regulated* intestinal expression of interleukin (II)-6 and [IL1b] more than 10-fold compared with the control group . Negative_regulation IL1B TAC3 23953566 2831833 The and IPC + TAC groups *down-regulated* intestinal expression of interleukin (II)-6 and [IL1b] more than 10-fold compared with the control group . Negative_regulation IL1B TAC4 23953566 2831834 The and IPC + TAC groups *down-regulated* intestinal expression of interleukin (II)-6 and [IL1b] more than 10-fold compared with the control group . Negative_regulation IL1B TANK 19910209 2203570 Knockdown by siRNA significantly *suppressed* soluble AIgG induced up-regulation of TRAF-2 , [IL-1beta] , and IL-6 . Negative_regulation IL1B TAS1R3 19505677 2098208 These results may suggest that trehalose *inhibits* LPS induced production of [IL-1beta] and TNF-alpha in mouse peritoneal macrophages by inhibiting degradation of IkappaB-alphavia the trehalose receptor . Negative_regulation IL1B TAT 22189681 2518546 Histological , Western blot , and reverse transcription-polymerase chain reaction data demonstrated that silk fibroin peptide or alone could *suppress* elevated levels of cyclooxygenase-2 , interleukin-6 , [interleukin-1beta] , and tumor necrosis factor-alpha induced by TPA . Negative_regulation IL1B TFPT 15913876 1427122 In liver also *reduced* the expression of [IL-1beta] and IFNgamma compared to LPS alone . Negative_regulation IL1B TFPT 16921924 1603031 The results also showed that 15 mg per kg feed significantly *inhibited* the expression of [IL-1beta] , IL-2 , IFN-alpha , IFN-gamma , but had no effect on iNOS . Negative_regulation IL1B TGFA 1940795 170616 Regulation of cytokine production in the human thymus : epidermal growth factor and *regulate* mRNA levels of interleukin 1 alpha (IL-1 alpha) , [IL-1 beta] , and IL-6 in human thymic epithelial cells at a post-transcriptional level . Negative_regulation IL1B TGFB1 10719355 676937 LPS induced levels of [IL-1beta] were *suppressed* by IL-10 , but not by IL-4 and . Negative_regulation IL1B TGFB1 10809798 692663 ( 10 ng/ml ) *inhibited* both [IL-1beta-] ( 5 ng/ml ) and TNF-alpha- ( 10 ng/ml ) induced expression of VCAM-1 ( MFI : IL-1beta=90. 8+/- 17.6 , IL-1beta+TGF-beta(1)=37.8+/-14.9 , TNF-alpha=113.6+/- 12.4 , TNF-alpha+TGF-beta(1)=64.3+/-13.8 , mean+/-SD , n=3 , P < 0.05 ) . Negative_regulation IL1B TGFB1 12237848 989221 *blocked* activation by [IL-1beta] when given prior to , or simultaneously with , IL-1beta . Negative_regulation IL1B TGFB1 12760902 1119665 IL-1beta and induced an activation of ERK p42/44 and p38 MAP kinases , and the MAP kinase inhibitors ( SB-202190 , PD-98059 , and U-0216 ) significantly *reduced* the [IL-1beta-] and TGF-beta1 induced IL-11 secretion . Negative_regulation IL1B TGFB1 1429677 202685 and interleukin (IL)-10 *inhibited* lipopolysaccharide (LPS) induced macrophage production of the inflammatory cytokines tumor necrosis factor-alpha (TNF) , IL-1 alpha , and [IL-1 beta] by contrasting post-transcriptional mechanisms . Negative_regulation IL1B TGFB1 17168860 343733 Loss of regulation ultimately *results* in a marked inflammatory response , as evidenced by the histologic appearance of the wound and increased expression of the inflammatory cytokines ( tumor necrosis factor-alpha , [interleukin-1beta] and 6 ) . Negative_regulation IL1B TGFB1 18611149 1979209 up-regulated the expression of SZP in cultured explants , but [IL-1beta] *down-regulated* it . Negative_regulation IL1B TGFB1 18611149 1979211 Real-time polymerase chain reaction analysis revealed that significantly up-regulated SZP expression and that [IL-1beta] *down-regulated* it . Negative_regulation IL1B TGFB1 19591943 2122824 Bacterial lipopolysaccharide (LPS) stimulated [IL-1beta] expression and *inhibited* that of the anti-inflammatory , although it was ineffective on TNF-alpha and IL-6 . Negative_regulation IL1B TGFB1 8624296 342943 Furthermore , *suppressed* secretion of IL-2 , IFN alpha , IFN gamma , TNF alpha but not of IL-1 alpha and [IL-1 beta] in whole blood cell cultures from healthy individuals . Negative_regulation IL1B TGFB1 8926042 343688 The anti-inflammatory cytokines IL-4 and IL-10 potently suppressed IL-1 beta plus IFN-gamma stimulated NO , while preferentially *inhibited* [IL-1 beta] plus TNF-alpha stimulated production of NO . Negative_regulation IL1B TGFB1 8956773 401459 In contrast , neither [IL-1 beta] mRNA expression nor IL-1 beta protein synthesis were *attenuated* by . Negative_regulation IL1B TGFB1 9587160 504605 In contrast , ( TGF-beta , 10 ng/ml ) , a cytokine which is abundant in bone matrix , *suppressed* median [IL-1 beta] release to 13 % of control value ( p < 0.01 ) . Negative_regulation IL1B TGFB2 10719355 676938 LPS induced levels of [IL-1beta] were *suppressed* by IL-10 , but not by IL-4 and . Negative_regulation IL1B TGFB2 1429677 202686 and interleukin (IL)-10 *inhibited* lipopolysaccharide (LPS) induced macrophage production of the inflammatory cytokines tumor necrosis factor-alpha (TNF) , IL-1 alpha , and [IL-1 beta] by contrasting post-transcriptional mechanisms . Negative_regulation IL1B TGFB2 1568479 186944 Transforming growth factor (TGF) beta 1 , and TGF beta 3 equipotently *attenuated* the [IL-1 beta-] and forskolin induced elevation of PLA2 mRNA , as well as PLA2 synthesis and secretion . Negative_regulation IL1B TGFB2 16400016 1506408 Semiquantitative reverse transcriptase-polymerase chain reaction of articular cartilage from six OA patients revealed that *suppressed* expression of matrix metalloproteinase-13 and matrix metalloproteinase-9 , early ( PTHrP ) and late ( COL10A1 ) differentiation related genes , and proinflammatory cytokines ( [interleukin-1beta] , tumor necrosis factor-alpha ) . Negative_regulation IL1B TGFB2 1708236 155099 *inhibits* [interleukin 1 beta-] and tumour necrosis factor alpha-induction of nitric oxide synthase in rat renal mesangial cells . Negative_regulation IL1B TGFB2 1708236 155100 Here we report that ( TGF beta 2 ) dose-dependently *inhibits* [IL-1 beta-] and TNF alpha stimulated cGMP formation in mesangial cells . Negative_regulation IL1B TGFB2 8926042 343689 The anti-inflammatory cytokines IL-4 and IL-10 potently suppressed IL-1 beta plus IFN-gamma stimulated NO , while preferentially *inhibited* [IL-1 beta] plus TNF-alpha stimulated production of NO . Negative_regulation IL1B TGFB2 9587160 504606 In contrast , ( TGF-beta , 10 ng/ml ) , a cytokine which is abundant in bone matrix , *suppressed* median [IL-1 beta] release to 13 % of control value ( p < 0.01 ) . Negative_regulation IL1B TGFB2 9704780 525624 Lipopolysaccharide induced prostaglandin E2 production by human decidual cells in vitro may be prevented by anti-interleukin-1beta and , and [interleukin-1beta] production may be *prevented* by anti-interleukin-1beta . Negative_regulation IL1B TGFB3 1429677 202687 and interleukin (IL)-10 *inhibited* lipopolysaccharide (LPS) induced macrophage production of the inflammatory cytokines tumor necrosis factor-alpha (TNF) , IL-1 alpha , and [IL-1 beta] by contrasting post-transcriptional mechanisms . Negative_regulation IL1B TGFB3 1568479 186945 Transforming growth factor (TGF) beta 1 , TGF beta 2 and equipotently *attenuated* the [IL-1 beta-] and forskolin induced elevation of PLA2 mRNA , as well as PLA2 synthesis and secretion . Negative_regulation IL1B TGFB3 8926042 343690 The anti-inflammatory cytokines IL-4 and IL-10 potently suppressed IL-1 beta plus IFN-gamma stimulated NO , while preferentially *inhibited* [IL-1 beta] plus TNF-alpha stimulated production of NO . Negative_regulation IL1B TGFB3 9587160 504607 In contrast , ( TGF-beta , 10 ng/ml ) , a cytokine which is abundant in bone matrix , *suppressed* median [IL-1 beta] release to 13 % of control value ( p < 0.01 ) . Negative_regulation IL1B TIMP1 16806998 1645997 This study aims to investigate the effects of HMW-HA on the gene expression of 16 OA-associated cytokines and enzymes , including [interleukin (IL)-1beta] , IL-6 , IL-8 , leukemia inhibitory factor (LIF) , tumor necrosis factor (TNF)-alpha , TNF-alpha converting enzyme (TACE) , matrix metalloproteinase (MMP)-1 , MMP-2 , MMP-3 , MMP-9 , MMP-13 , tissue *inhibitor* of metalloproteinase ( ) -1 , TIMP-2 , aggrecanase-1 , aggrecanase-2 , and inducible nitric oxide synthase (iNOS) , in fibroblast-like synoviocytes ( FLS ) from patients with early stage OA . Negative_regulation IL1B TIMP1 18261936 1944001 For completeness , interleukin (IL)-6 , [IL-1beta] , matrix metalloproteinase (MMP)-2 , MMP-3 , MMP-9 , tissue *inhibitor* of metalloproteinase ( ) -1 , prostaglandin E2 ( PGE2 ) , leukotriene B4 (LTB4) , tumor necrosis factor alpha (TNF)-alpha and monocyte chemoattractant protein-1 ( MCP-1 ) accumulation have been evaluated in adiponectin stimulated chondrocytes cell culture supernatants . Negative_regulation IL1B TIMP1 18263696 1924676 After CCl ( 4 ) treatment , the mRNA level of A ( 1 ) , A ( 2A ) , A ( 2B ) , and A ( 3 ) adenosine receptors , tumor necrosis factor-alpha , [interleukin (IL) -1beta] , IL-13r alpha1 , matrix metalloproteinase (MMP)-2 , MMP-14 , tissue *inhibitor* of metalloproteinase ( ) -1 , and TIMP-2 , and IL-13 level increased markedly in both CD73KO and WT mice , but Col1 alpha1 , Col3 alpha1 , and transforming growth factor-beta1 mRNA increased much more in WT mice than that in KO mice . Negative_regulation IL1B TIMP1 20237245 2272979 Quantitative real-time PCR was performed to measure the expression of tumor necrosis factor-alpha (TNF) , [interleukin-1beta (IL1B)] , matrix metalloproteinase-1 (MMP1) , MMP-2 , MMP-9 , tissue *inhibitor* of matrix metalloproteinase 1 ( ) , TIMP-2 , and hypoxanthine phosphoribosyl transferase-1 ( HPRT1 ) . Negative_regulation IL1B TIMP1 8403497 232320 These results suggest that the cytokine effects on production are different among the different cell types , and that either [IL-1 beta] or TNF-alpha *induce* cartilage matrix degradation by disrupting the collagenase/TIMP balance , while , on the other hand , IL-6 protects the tissue through an opposite effect . Negative_regulation IL1B TJP1 20632386 2316673 Our results showed that GDNF resulted in a significant reduction in enhanced permeability , *inhibited* MPO activity , [IL-1beta] and TNF-alpha expression , and increased and Akt expression . Negative_regulation IL1B TKT 11922921 926476 Furthermore , *inhibited* both [IL-1beta] and TNF-alpha secretion induced by PMA and A23187 , respectively . Negative_regulation IL1B TLR1 17467812 1737433 Inhibition of *induced* [IL-1beta] production , which partially reversed the upregulation of RANKL induced by TLR ligands . Negative_regulation IL1B TLR10 17467812 1737441 Inhibition of *induced* [IL-1beta] production , which partially reversed the upregulation of RANKL induced by TLR ligands . Negative_regulation IL1B TLR2 15731031 1377561 Induction of [interleukin-1beta (IL-1beta)] , IL-6 , IL-8 , or tumor necrosis factor alpha in human THP-1 cells by LT-IIaB or LT-IIbB was *inhibited* by but not by anti-TLR4 antibody . Negative_regulation IL1B TLR2 16547271 1537792 Distinct *roles* of and the adaptor ASC in [IL-1beta/IL-18] secretion in response to Listeria monocytogenes . Negative_regulation IL1B TLR2 17312106 1699601 and TLR4-BB peptides ( BBPs ) *inhibited* NF-kappaB translocation and early [IL-1beta] mRNA expression induced by LPS , and the lipopeptides S-[2,3-bis ( palmitoyloxy ) - ( 2-RS ) -propyl ] -N-palmitoyl- ( R ) -Cys-Ser-Lys ( 4 ) -OH ( P3C ) and S-[2,3-bis ( palmitoyloxy ) - ( 2-RS ) -propyl ] -Cys-Ser-Lys ( 4 ) -OH ( P2C ) . Negative_regulation IL1B TLR2 17467812 1737434 Inhibition of *induced* [IL-1beta] production , which partially reversed the upregulation of RANKL induced by TLR ligands . Negative_regulation IL1B TLR2 19543380 2099235 Transcription of the [Il1b] gene was markedly *impaired* in ( -/- ) and MyD88 ( -/- ) BMDM , whereas mature and secreted IL-1beta was massively reduced in NALP3 ( -/- ) BMDMs or in human THP-1 macrophages with reduced expression of NALP3 , ASC or caspase-1 by shRNAs . Negative_regulation IL1B TLR3 17467812 1737435 Inhibition of *induced* [IL-1beta] production , which partially reversed the upregulation of RANKL induced by TLR ligands . Negative_regulation IL1B TLR4 17312106 1699602 TLR2- and peptides ( BBPs ) *inhibited* NF-kappaB translocation and early [IL-1beta] mRNA expression induced by LPS , and the lipopeptides S-[2,3-bis ( palmitoyloxy ) - ( 2-RS ) -propyl ] -N-palmitoyl- ( R ) -Cys-Ser-Lys ( 4 ) -OH ( P3C ) and S-[2,3-bis ( palmitoyloxy ) - ( 2-RS ) -propyl ] -Cys-Ser-Lys ( 4 ) -OH ( P2C ) . Negative_regulation IL1B TLR4 17467812 1737436 Inhibition of *induced* [IL-1beta] production , which partially reversed the upregulation of RANKL induced by TLR ligands . Negative_regulation IL1B TLR5 17467812 1737437 Inhibition of *induced* [IL-1beta] production , which partially reversed the upregulation of RANKL induced by TLR ligands . Negative_regulation IL1B TLR6 17467812 1737442 Inhibition of *induced* [IL-1beta] production , which partially reversed the upregulation of RANKL induced by TLR ligands . Negative_regulation IL1B TLR7 17467812 1737438 Inhibition of *induced* [IL-1beta] production , which partially reversed the upregulation of RANKL induced by TLR ligands . Negative_regulation IL1B TLR7 19265172 2045534 expression was also *necessary* for the IFN-beta1a induced inhibition of [IL-1beta] and IL-23 and the induction of IL-27 secretion by DCs . Negative_regulation IL1B TLR8 17467812 1737439 Inhibition of *induced* [IL-1beta] production , which partially reversed the upregulation of RANKL induced by TLR ligands . Negative_regulation IL1B TLR9 17467812 1737440 Inhibition of *induced* [IL-1beta] production , which partially reversed the upregulation of RANKL induced by TLR ligands . Negative_regulation IL1B TNF 10224371 610184 In addition , Ro 31-8220 ( a PKC inhibitor ) inhibited OX8 induced iNOS upregulation , NO and [IL-1beta] production , but did not *inhibit* production . Negative_regulation IL1B TNF 10603404 655257 In contrast to the response to LPS , where , IL-1beta , IL-6 , and IL-8 appear almost simultaneously , the human monocyte response to GBS results in the production of TNF-alpha but *delayed* appearance of [IL-1beta] , IL-6 , and IL-8 . Negative_regulation IL1B TNF 11777983 899881 Furthermore , IL-17 , IL-1beta , and induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs , and specific MAPK inhibitors ( SB203580 , PD98059 , and U0216 ) significantly *reduced* IL-17- , [IL-1beta-] , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Negative_regulation IL1B TNF 12056510 951859 did not affect TNFR-1 expression in the liver and *resulted* in time dependent up-regulation of iNOS , [IL-1beta] and HO-1 . Negative_regulation IL1B TNF 1421015 202094 Recombinant [IL-1 beta] *induced* a very low level of production in PMA treated cells . Negative_regulation IL1B TNF 14734475 1199279 However , in the resistant cells , the production of [IL-1beta] and IL-6 were specifically *impaired* in response to . Negative_regulation IL1B TNF 15198989 1273878 In wild-type healthy control , CD and ulcerative colitis individuals , low-dose MDP and alone *results* in only modest [IL-1beta] protein induction . Negative_regulation IL1B TNF 15358691 1293567 In order to better understand the control of IL-1beta activity in the airway mucosa , the *role* ( s ) of , cyclic adenosine monophosphate ( cAMP ) and cyclic guanosine monophosphate ( cGMP ) in the release of [IL-1beta] and its inhibitors by cultured HAECs were examined . Negative_regulation IL1B TNF 15916742 1412860 Furthermore , MT-Se significantly lowered an increase in TNF-alpha and [IL-1beta] levels in the liver and *inhibited* the production of and IL-1beta by peritoneal macrophages . Negative_regulation IL1B TNF 16011257 1431561 Ginkgolide B was shown to significantly inhibit angiogenesis of the murine chronic granulomatous air pouch model , reduce the IL-1beta and levels in mice serums , and significantly *inhibit* [IL-1beta] and TNF-alpha mRNA expression and protein secretion in supernatants of U937 cell culture . Negative_regulation IL1B TNF 16202497 1500968 All the tested hardwood and softwood dusts induced expression and *inhibited* [IL-1beta] expression . Negative_regulation IL1B TNF 16211305 1464585 Neither extract affected and iNOS mRNA expression in LPS stimulated cells , but at a 1/100 dilution they both *reduced* [IL-1beta] mRNA expression in LPS stimulated cells ( p < 0.01 ) . Negative_regulation IL1B TNF 16988225 1617886 Although alpha production was reduced in mice infected with the mutant of devoid LOS , both LOS mutants *induced* production of other proinflammatory cytokines , such as [interleukin-1beta (IL-1beta)] , IL-6 , and the murine IL-8 homolog KC. Together , these results suggest that meningococcal LOS plays a role during the early infectious and invasive process , and they further confirm that other , nonlipopolysaccharide components of Neisseria meningitidis may significantly contribute to the inflammatory reaction of the host . Negative_regulation IL1B TNF 17618462 1774999 The [IL-1beta] expressions were inhibited by ketotifen in the two strains , but expression was *inhibited* in the C3H/HeN mice after ketotifen treatment . Negative_regulation IL1B TNF 17907382 1803278 Compared with model group , [IL-1beta] mRNA expression of the local inflammatory tissues in IND and EA-post-treatment groups was down-regulated , and mRNA expression in Rofecoxib and two EA groups *down-regulated* slightly . Negative_regulation IL1B TNF 18480275 1910666 Consistently , and IL-1beta enhanced AMPA- or NMDA induced currents , and [IL-1beta] and IL-6 *suppressed* GABA- and glycine induced currents . Negative_regulation IL1B TNF 19046141 1999004 P4 enhanced the production of [IL-1beta] and IL-8 , but *inhibited* production by monocytes stimulated with either organism . Negative_regulation IL1B TNF 19060786 2105763 Intravenous LPS ( 10-50 mg/kg ) dose-dependently increased plasma endotoxin and reactive oxygen species in the blood , bile , and liver and increased plasma alanine aminotransferase and aspartate aminotransferase levels as well as , monocyte chemoattractant protein 1 , tissue *inhibitor* of metalloproteinase 1 , [IL-1beta] , and IL-6 levels in the rats . Negative_regulation IL1B TNF 20712904 2317876 Resveratrol inhibited LPS induced expression and release of , IL-6 , MCP-1 , and iNOS/NO in both cell types with more potency in microglia , and *inhibited* LPS induced expression of [IL-1beta] in microglia but not astrocytes . Negative_regulation IL1B TNF 2788284 116863 In addition , simultaneous stimulation with recombinant IL-1 ( alpha or beta ) and recombinant *resulted* in a synergistic increase in [IL-1 beta] mRNA levels . Negative_regulation IL1B TNF 7743669 306072 LPS , IFN-gamma or had no effect on spontaneous IL-6 production , and neither *resulted* in the secretion of [IL-1 beta] or TNF-alpha . Negative_regulation IL1B TNF 8608789 342799 *prevents* [interleukin-1 beta] from augmenting capsaicin induced vasodilatation in the rat skin . Negative_regulation IL1B TNF 8792802 381022 In addition , Et-1 *enhanced* significantly the [IL-1 beta] mediated upregulation of VCAM-1 expression , whereas mediated expression of VCAM-1 was downregulated by Et-1 . Negative_regulation IL1B TNF 8840155 386689 The data provide evidence for an in vivo *role* for epidermal IL-1 alpha , IL-1 beta and transcription in the regulation of [IL-1 beta] and TNF-alpha polypeptide levels in the epidermis in response to this common contact allergen . Negative_regulation IL1B TNF 8891757 392041 Four non-steroidal antiinflammatory drugs , indomethacin , flurbiprofen , naproxen and meclofenamic acid , inhibited basal , IL-1 beta- and TNF-alpha stimulated PGE2 formation in the MG-63 cells without affecting [IL-1 beta-] or induced *inhibition* of osteocalcin and type I collagen formation . Negative_regulation IL1B TNF 9266282 449460 Benzydamine ( 6.25-50 microM ) *inhibited* Candida induced and , to a lesser extent , [interleukin-1 beta] production , whereas it did not affect interleukin-6 release . Negative_regulation IL1B TNFRSF11B 19406240 2095649 In PC-3 cells , IL-1beta stimulated IL-6 and release , and dexamethasone dose-dependently *inhibited* [IL-1beta-inducible] IL-6 release , and constitutive and IL-1beta-inducible OPG release . Negative_regulation IL1B TNFRSF1B 17636564 1798727 As certolizumab pegol , infliximab , and adalimumab , but not , almost completely *inhibited* LPS induced [IL-1beta] release from monocytes , inhibition of cytokine production may be important for efficacy of anti-TNFalpha agents in CD . Negative_regulation IL1B TNFRSF1B 23620660 2775047 As CZP , infliximab , and adalimumab , but not , almost completely *inhibited* lipopolysaccharide induced [interleukin-1 beta] release from monocytes , this cytokine production inhibition may be relevant for drug efficacy . Negative_regulation IL1B TRD 17543144 1751816 at non-cytotoxic concentrations , inhibited PDGF triggered RA FLS proliferation , *reduced* [IL-1beta] - stimulated production of IL-6 and slightly decreased intracellular content of IL-8 . Negative_regulation IL1B TRIM26 7544757 318393 In contrast , significantly *suppressed* PMA induced TNF-alpha and [IL-1 beta] production by U937 cells in a time and dose dependent fashion . Negative_regulation IL1B TROVE2 10954049 724511 Production of tumor necrosis factor (TNF)-alpha and [IL-1beta] by mouse mesangial cells was not *blocked* by but production of IL-4 by these cells was inhibited by it ( > 0.1 mM ) . Negative_regulation IL1B TXN 19561107 2104175 Not only silencing of , but also of the ROS scavenger superoxide dismutase 1 *results* in inhibition of [IL-1beta] secretion . Negative_regulation IL1B TYR 8228247 235723 Conversely , the IL-1 beta converting enzyme inhibitor , ( L-709,049 ) and the anti-inflammatory agent [ 5- ( 4-pyridyl ) 6 ( 4-fluorophenyl ) -2,3-dihydroimidazo ( 2,1-b ) thiazole ] ( SK & F 86002 ) *inhibited* [IL-1 beta] release in both the standard and staged release assays with IC50 of 1 microM . Negative_regulation IL1B TYR 9050895 417096 Only z-VAD.FMK and reduced brain swelling , and N-benzyloxycarbonyl-Asp-Glu-Val-Asp-fluoromethylketone did not *attenuate* the ischemia induced increase in tissue [IL-1beta] levels . Negative_regulation IL1B U2AF1 15950937 1421596 Reducing the ( 35 ) level in HeLa cells and infecting HeLa cells with wild-type *caused* a decrease in the expression of the il-8 , RANTES , GM-CSF , and [il-1beta] genes as examined by RT-PCR . Negative_regulation IL1B U2AF2 15950937 1421597 Reducing the ( 35 ) level in HeLa cells and infecting HeLa cells with wild-type *caused* a decrease in the expression of the il-8 , RANTES , GM-CSF , and [il-1beta] genes as examined by RT-PCR . Negative_regulation IL1B UMOD 8186192 256660 Nuclear run-on experiments showed that *inhibited* transcription of the [IL-1 beta] gene . Negative_regulation IL1B VCAM1 8792802 381023 In addition , Et-1 *enhanced* significantly the [IL-1 beta] mediated upregulation of VCAM-1 expression , whereas TNF-alpha mediated expression of was downregulated by Et-1 . Negative_regulation IL1B WAS 9666273 518553 It was found that *suppressed* IL-12 , IL-15 and IL-6 and increased IL-1 alpha , [IL-1 beta] , and TNF alpha in all of the stimulated cultures . Negative_regulation IL1B WNK1 24009751 2836900 Ectopic expression of NFkB in AGS cells *resulted* in about nine-fold transcriptional repression of gastrin both in the presence and absence of [IL1B] . Negative_regulation IL1B WNT11 16754689 1590185 Opposing *roles* of WNT-5A and in [interleukin-1beta] regulation of type II collagen expression in articular chondrocytes . Negative_regulation IL1B WNT5A 16754689 1590186 Opposing *roles* of and WNT-11 in [interleukin-1beta] regulation of type II collagen expression in articular chondrocytes . Negative_regulation IL1B YY1 10860774 704875 These investigations indicate that sequences in and around the third upstream serum response element ( SRE3 ) bind and are *required* for [IL-1 beta] mediated repression . Negative_regulation IL1B ZP2 9053458 417240 In the present report we investigated the *role* of microglial receptor in [IL-1 beta] release triggered by LPS . Negative_regulation IL1R1 S100B 9692960 523286 The synthetic peptide containing the latter sequence blocked the activation of guanylate cyclase and *inhibition* of [p80] phosphorylation , while the peptide containing the former sequence blocked cyclase activation and simulated S100 beta in inhibiting p80 phosphorylation . Negative_regulation IL1R1 TLR7 15843532 1398451 However , AcPL is dispensable for the activation or *inhibition* of [IL-1R] and the various signals that we have examined . Negative_regulation IL1R2 AKT1 22940184 2701670 A further study indicated that alantolactone attenuated the phosphorylation of and *inhibited* the expression of MyD88 and [Toll-interleukin 1 receptor] domain containing adaptor protein ( TIRAP ) , an upstream signaling molecule required for IKK and MAPKs activation . Negative_regulation IL1R2 AKT2 22940184 2701671 A further study indicated that alantolactone attenuated the phosphorylation of and *inhibited* the expression of MyD88 and [Toll-interleukin 1 receptor] domain containing adaptor protein ( TIRAP ) , an upstream signaling molecule required for IKK and MAPKs activation . Negative_regulation IL1R2 AKT3 22940184 2701672 A further study indicated that alantolactone attenuated the phosphorylation of and *inhibited* the expression of MyD88 and [Toll-interleukin 1 receptor] domain containing adaptor protein ( TIRAP ) , an upstream signaling molecule required for IKK and MAPKs activation . Negative_regulation IL1R2 IL1RN 1830582 163619 competitively *inhibits* the binding of interleukin-1 to the type II [interleukin-1 receptor] . Negative_regulation IL1R2 MYD88 19679662 2144281 Moreover , overexpression of a green fluorescent protein ( GFP ) -tagged protein ( GFP-MyD88- ( 27-72 ) ) , comprising the Glu ( 52 ) and Tyr ( 58 ) residues , interfered with recruitment of both IRAK1 and IRAK4 by MyD88 and *suppressed* NF-kappaB activation by the [interleukin-1 receptor] but not by the MyD88 independent TLR3 . Negative_regulation IL1R2 SIGIRR 15866876 1419116 *inhibits* [interleukin-1 receptor-] and toll-like receptor 4-mediated signaling through different mechanisms . Negative_regulation IL1R2 UBD 16702978 1570075 In the presence of ionomycin , overexpression of in T ( h ) cells *leads* to the induction of [IL1R2] that resemble FOXP3 transduced T ( h ) cells and naturally derived T ( reg ) cells . Negative_regulation IL1RL1 GATA1 22865859 2677387 GATA2 is a critical transactivator for the human IL1RL1/ST2 promoter in mast cells/basophils : opposing *roles* for GATA2 and in human [IL1RL1/ST2] gene expression . Negative_regulation IL1RL1 GATA2 22865859 2677388 GATA2 is a critical transactivator for the human IL1RL1/ST2 promoter in mast cells/basophils : opposing *roles* for and GATA1 in human [IL1RL1/ST2] gene expression . Negative_regulation IL1RN IL1B 19825520 2148942 Pharmacological inhibition of the mevalonate pathway specifically enhanced the release of IL-1alpha , and IL-18 and *inhibited* [IL-1ra] production by LPS activated PBMCs and THP-1 cells . Negative_regulation IL1RN IL1B 7802085 284459 Intraamniotic infection or the appearance of in the amniotic fluid *results* in increased production of [interleukin-1 receptor antagonist] . Negative_regulation IL1RN IL1B 8132734 251605 IL-4 enhanced LPS induced [IL-1ra] production by PMN and *inhibited* LPS induced production . Negative_regulation IL1RN IL1B 8568265 350982 Acute phase levels of C-reactive protein enhance IL-1 beta and [IL-1ra] production by human blood monocytes but *inhibit* and IL-1ra production by alveolar macrophages . Negative_regulation IL1RN IL1B 8809146 383079 IgA induced higher levels of [IL-1Ra] than Haemophilus influenzae type b ( Hib ) expressing lipopolysaccharide (LPS) , purified LPS or phorbol myristate acetate ( PMA ) , without induction of IL-1 beta release , and even *inhibited* LPS induced release . Negative_regulation IL1RN IL1B 8814267 383524 In contrast , IL-12 stimulated the production of and MCP-1 in TNF-alpha stimulated MNC and *inhibited* [IL-1ra] synthesis in cytokine stimulated cells . Negative_regulation IL1RN IL1B 9783809 540701 RA enhanced and *inhibited* [IL-1ra] production by 4beta phorbol 12beta-myristate-13alpha acetate ( PMA ) - and lipopolysaccharide (LPS) stimulated human alveolar macrophages . Negative_regulation IL1RN IL1B 9811059 545562 MTX had fewer effects on phenotypic differentiation of human BMMC and PBMC , but did stimulate [IL-1Ra] release and *inhibit* synthesis in BMMC . Negative_regulation IL1RN TLR7 19922413 2190130 MSK1 regulates the transcription of [IL-1ra] in *response* to activation in macrophages . Negative_regulation IL1RN TNF 22675954 2611446 The production of IL-8 was significantly increased by IL-1alpha or , and the increase of IL-8 stimulated by IL-1alpha was *suppressed* by [IL-1 ra] in a dose dependent manner . Negative_regulation IL1RN TNF 8158047 253431 To assess the *role* of in the appearance of [interleukin-1 receptor antagonist] ( IL-1RA ) in endotoxemia , 4 healthy humans were studied after a bolus intravenous injection of recombinant human TNF ( 50 micrograms/m2 ) . Negative_regulation IL1RN TNF 9449707 483971 IL-18 did not *induce* antiinflammatory cytokines , [IL-1Ra] , or IL-10 , although IL-18 induction of was inhibited by IL-10 . Negative_regulation IL2 ALOX5 1750068 172149 Although <5-LO> potently *inhibited* [IL-2] production , it had no effect on IL-2 responsiveness or IL-2 receptor acquisition . Negative_regulation IL2 ARSA 11238116 790481 *inhibited* IL-4 , but not [IL-2] , promoter-driven chloramphenicol acetyltransferase expression in transiently transfected Jurkat T cells . Negative_regulation IL2 ARSA 1981793 148663 Neither SP nor <5-ASA> *inhibited* the [IL-2] production . Negative_regulation IL2 CD14 9300716 453878 Functional *role* for the myeloid differentiation antigen in the activation of human monocytes by [IL-2] . Negative_regulation IL2 EPHB2 15339934 1333558 The inhibition of sustained activation by either expression of a dominant negative B-Raf or treatment with a MEK inhibitor *resulted* in a decrease of the TCR stimulated nuclear factor of activated T cells ( NFAT ) activity and [IL-2] production . Negative_regulation IL2 EPHB2 22932814 2740234 Morphine pretreatment enhanced phosphorylation , but *inhibited* I?Ba phosphorylation and [IL-2] gene expression in activated T cells . Negative_regulation IL2 EPHB2 8638107 362453 These results suggest that a specific block in the activation of and JNK *contributes* to defective [IL-2] production in clonal anergy . Negative_regulation IL2 EPHB2 8642312 362944 Our results suggest that defects in both JNK and may *result* in the decreased AP-1 activity and the reduced [IL-2] transcription observed in anergic T cells . Negative_regulation IL2 FAS 12505729 1038274 PD analyses suggested that in NHS samples containing CsA+SRL ( n=5 ) , ( 1 ) PMA-Ionomycin stimulated T-cell expression of intracellular [IL-2] , TNF-alpha , and IFN-gamma was inhibited by CsA , and minimally by SRL , and ( 2 ) the two agents *inhibited* pokeweed mitogen ( PWM ) -stimulated B-cell expression of CD54 and , but not CD86 ( ICAM-1 , Fas antigen , and B7.2 ) , synergistically . Negative_regulation IL2 FAS 17447415 1665562 Stimulation of by agonistic antibodies ( 7C11 ) *resulted* in expression of [IL-2] in primary T cells , which was further enhanced when caspase activity was blocked by ZVAD . Negative_regulation IL2 FAS 22429591 2582801 Consequently , lowered expression of IL-2 and genes *resulted* in decreased [IL-2] secretion and CD95L dependent AICD . Negative_regulation IL2 FAS 9469443 485886 We now report that cells infected with T. gondii are resistant to multiple inducers of apoptosis , including *dependent* and Fas independent CTL mediated cytotoxicity , [IL-2] deprivation , gamma irradiation , UV irradiation , and the calcium ionophore beauvericin . Negative_regulation IL2 FOXO1 21730069 2471513 However , the high level of [IL-2] production by STAT3-deficient T-cells was partially *restored* to normal levels by overexpressing . Negative_regulation IL2 HRH1 15021962 1221738 Depletion of the *resulted* in decreases in the release of [IL-2] and IL-10 from both CD4+ and CD8+ cells and increases in the release of IL-4 from CD4+ T cells and IFN-gamma from CD8+ cells . Negative_regulation IL2 IFI27 11745394 888909 however , physiological levels of ( Kip1 ) did not *prevent* [IL-2] transcription . Negative_regulation IL2 IL1B 14632664 1170694 Mitogen stimulation of embryonic day 18 and day 1 post-hatch thymocytes *induced* up-regulation of IFN-gamma , IL-1beta and TGF-beta transcripts , and down-regulation of IFN-alpha , IFN-beta and [IL-2] transcripts , with a higher induction of IFN-gamma , and TGF-beta transcripts in more immature T-cell-receptor negative ( TCR- ) than TCR+ ( TCR1+ , TCR2+ , or TCR3+ ) subsets . Negative_regulation IL2 IL1B 15048152 1225141 We have shown that the sera of lung cancer patients affect the response of ConA stimulated normal peripheral blood mononuclear cells by decreasing the expression of [IL-2Ralpha] and *inhibiting* the release of and IL-2 . Negative_regulation IL2 IL1B 1617893 191311 Further and TNF-a were significantly elevated in RA patients with active disease and [IL-2] was significantly *reduced* when compared with patients with low active disease . Negative_regulation IL2 IL1B 2143761 140020 Culture medium conditioned by phorbol 12-myristate 13-acetate differentiated THP-1 cells contained interleukin 1 (IL-1) antagonist activity as measured by inhibition of both binding to receptors on YT cells and *inhibition* of IL-1/phytohemagglutinin stimulated [IL-2] synthesis by LBRM-33-1A5 T cells . Negative_regulation IL2 ITGB2 1673435 154979 abrogated T-dependent responses to IL2 which were inducible after 2 days in culture , but did not *inhibit* the induction of this [IL2] responsiveness . Negative_regulation IL2 ITGB2 3926885 50025 , but not anti-Ly-2 , markedly *inhibited* the induction of the [IL 2] receptor on the Ly-2+ subset . Negative_regulation IL2 KLF9 14976188 1236200 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL2 MAP2K6 10545489 564519 Suppression of activation of both and p38 MAPK *resulted* in significant inhibition of [IL-2] gene expression . Negative_regulation IL2 MMP28 20921282 2337490 Furthermore , [IL-2/a-CD40] *induced* the IFN-?- and NO-dependent decrease in expression and activity , concomitant with increases in tissue inhibitor of metalloproteinase ( TIMP ) 1 and E-cadherin expression within tumors . Negative_regulation IL2 MMP28 21103959 2407526 The inhibition of activity in the MSC CM by GM6001 abrogated CD25 cleavage and *restored* [IL-2] production from the activated splenocytes . Negative_regulation IL2 MMP7 20921282 2337505 Furthermore , [IL-2/a-CD40] *induced* the IFN-?- and NO-dependent decrease in expression and activity , concomitant with increases in tissue inhibitor of metalloproteinase ( TIMP ) 1 and E-cadherin expression within tumors . Negative_regulation IL2 MMP7 21103959 2407541 The inhibition of activity in the MSC CM by GM6001 abrogated CD25 cleavage and *restored* [IL-2] production from the activated splenocytes . Negative_regulation IL2 RAB31 10799850 691357 Monoclonal anti-Edg-4 , like LPA , *suppressed* stimulated [IL-2] secretion from CD4+ T cells , but not CD8+ T cells . Negative_regulation IL2 RAB31 2526799 115321 We further demonstrate that CsA inhibits preferentially [IL-2] production and anti-IL2 *inhibits* T cell proliferation by blocking an absorption of IL-2 by activated lymphocytes . Negative_regulation IL2 SPHK1 16272312 1479405 Consistently , overexpression of dominant negative *increased* the production of [IL-2] , TNF-alpha , and IFN-gamma in Th1 cells . Negative_regulation IL2 STAT4 10072548 594516 We examined this and found that TGF-beta1 did not have any effect on IL-12 induced phosphorylation of JAK2 , TYK2 , and although TGF-beta1 *inhibited* [IL-2-] and IL-12 induced IFN-gamma production . Negative_regulation IL2 STAT4 16493033 1528687 Analyses using various mice lacking a signaling molecule revealed that the inhibition of [IL-2] production was *dependent* on STAT1 , but not on STAT3 , , and T-bet , and was highly correlated with the induction of SOCS3 expression . Negative_regulation IL2 TCN1 15746085 1409706 Activation of Th1 and cell adenosine A2A receptors directly *inhibits* [IL-2] secretion in vitro and IL-2-driven expansion in vivo . Negative_regulation IL2 TLR7 20677943 2305550 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL2 TNF 11377186 820171 In order to assess the immunological activity , the prodrugs were tested using and [interleukin-2] *inhibition* assays . Negative_regulation IL2 TNF 11541007 343731 However , the activity of the production of in 48-hour PHA-cultures of lymphocytes was unchanged and the biological activity of [IL-2] was not *reduced* . Negative_regulation IL2 TNF 12022445 943274 YH-Tang significantly inhibited interleukin (IL)-1 , IL-4 , IL-6 and secretion in astrocytes stimulated with SP and LPS , but did not *inhibit* interferon-y ( IFN-gamma ) and [IL-2] secretion significantly . Negative_regulation IL2 TNF 12781508 1095699 In general , most fluoroquinolone derivatives superinduce in-vitro [interleukin 2] synthesis but *inhibit* synthesis of interleukin 1 and ; Negative_regulation IL2 TNF 15914319 1412622 CGP41251 inhibited production by T cells with an IC ( 50 ) of 0.5 microM and did not significantly *inhibit* the production of [IL-2] or IFN-gamma . Negative_regulation IL2 TNF 1617893 191310 Further IL-1b and were significantly elevated in RA patients with active disease and [IL-2] was significantly *reduced* when compared with patients with low active disease . Negative_regulation IL2 TNF 16314006 1526171 Specific IgG prevents enteroinvasive Escherichia coli/Salmonella typhi induced diarrhea and may exert an effective protection by enhancing splenic NK cell activity , elevating [IL-2] level and *inhibiting* excessive release of in mice . Negative_regulation IL2 TNF 17804196 1795304 significantly suppressed leukocyte infiltration in the inflamed colon , and *down-regulated* IFN-gamma , [IL-2] and TNF secretion by lamina propria CD4 ( + ) T cells . Negative_regulation IL2 TNF 19013541 2022437 Ursolic acid *enhanced* [IL-2] and IFN-gamma production in response to Con A stimulation , whereas it inhibited production in response to LPS stimulation . Negative_regulation IL2 TNF 19014336 2022440 The addition of LPS to PBMCs cocultured with bovine CPC significantly stimulated the release of [IL-2] and *inhibited* the early release of , IL-6 , and IL-4 ( p < 0.02 ) . Negative_regulation IL2 TNF 19014336 2022451 Phytohemagglutinin stimulation in combination with bovine CPC significantly increased the secretion of IL-10 and [IL-2] at 6 h of culture and *inhibited* IFN-gamma and ( p < 0.05 ) . Negative_regulation IL2 TNF 1901829 155911 [IL-2] *induced* high levels of and IFN-gamma secretion in both groups . Negative_regulation IL2 TNF 2029793 157594 The suppression of high-affinity [IL-2R] induction on T cells did not *result* from and beta or from transforming growth factor-beta as these cytokines were not detected in the cell-free supernatant from the MJ TIL culture . Negative_regulation IL2 TNF 23112985 2367112 Six weeks of EPA+vitamin E supplementation *enhances* the plasma levels of [IL-2] and erythrocytes glutathione reductase , whereas it reduces , and 6 weeks of EPA supplementation alone enhances only the serum level of MDA . Negative_regulation IL2 TNF 2526178 114013 In contrast , did *block* proliferative responses to [IL-2] , but only by those clones which were incapable of responding to IL-4 . Negative_regulation IL2 TNF 8346413 226970 *mediated* regulation of low-dose [IL-2] activation occurs even at late stages ( effector phase ) of LAK development . Negative_regulation IL2 TNF 8402935 230882 Pivotal *role* of endogenous in the [IL-2-driven] activation and proliferation of the functionally immature NK free subset . Negative_regulation IL2 TNF 8513511 221813 IL-1 alpha , IL-4 , IL-6 , IL-10 , and IFN-gamma levels were decreased by treatment with low doses of DEX ( 30 mg/kg ) , whereas higher doses were required to *inhibit* production of [IL-2] , IL-3 , and . Negative_regulation IL2 TNF 8833901 386002 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL2 TNF 8957229 401625 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL20 KLF9 14976188 1236217 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL20 TLR7 20677943 2305560 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL20 TNF 8833901 386003 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL20 TNF 8957229 401626 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL21 KLF9 14976188 1236234 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL21 TLR7 20677943 2305570 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL21 TNF 8833901 386004 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL21 TNF 8957229 401627 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL21R TLR7 22530560 2686581 activation of B cells in vitro *resulted* in [IL-21R] up-regulation . Negative_regulation IL22 EPHB2 20061405 2205479 In this study , we report that pharmacologic inhibition of signaling enhances the in vitro differentiation of Th17 cells and *increases* their gene expression of il-17a , il-17f , il-21 , [il-22] , and il-23r . Negative_regulation IL22 KLF9 14976188 1235928 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL22 MAP2K6 20061405 2205485 In this study , we report that pharmacologic inhibition of signaling enhances the in vitro differentiation of Th17 cells and *increases* their gene expression of il-17a , il-17f , il-21 , [il-22] , and il-23r . Negative_regulation IL22 TLR7 20677943 2305400 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL22 TNF 8833901 385987 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL22 TNF 8957229 401610 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL23A EPHB2 20851927 2388988 Inhibition of p38 , but not , *attenuated* production of both [IL12/IL23p40] and TNF-a . Negative_regulation IL23A TLR7 19265172 2045530 expression was also *necessary* for the IFN-beta1a induced inhibition of IL-1beta and [IL-23] and the induction of IL-27 secretion by DCs . Negative_regulation IL23A TLR7 20570038 2290409 The effect on IL-1beta , [IL-23] and IL-27 production in DCs was *mediated* by the up-regulation of and its downstream signaling molecules . Negative_regulation IL23R EPHB2 20061405 2205495 In this study , we report that pharmacologic inhibition of signaling enhances the in vitro differentiation of Th17 cells and *increases* their gene expression of il-17a , il-17f , il-21 , il-22 , and [il-23r] . Negative_regulation IL23R MAP2K6 20061405 2205501 In this study , we report that pharmacologic inhibition of signaling enhances the in vitro differentiation of Th17 cells and *increases* their gene expression of il-17a , il-17f , il-21 , il-22 , and [il-23r] . Negative_regulation IL24 KLF9 14976188 1235894 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL24 TLR7 20677943 2305380 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL24 TNF 8833901 385985 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL24 TNF 8957229 401581 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL25 KLF9 14976188 1235911 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL25 TLR7 20677943 2305390 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL25 TNF 20944558 2389300 Stimulation of normal intestinal explants with , but not interferon-? ( IFN-? ) or IL-21 , *reduced* [IL-25] synthesis . Negative_regulation IL25 TNF 8833901 385986 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL25 TNF 8957229 401609 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL26 KLF9 14976188 1236013 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL26 TLR7 20677943 2305440 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL26 TNF 8833901 385991 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL26 TNF 8957229 401614 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL27 KLF9 14976188 1236030 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL27 TLR7 20677943 2305450 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL27 TNF 8833901 385992 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL27 TNF 8957229 401615 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL27RA TNF 15749890 1379720 In the absence of [WSX-1] , an increased production of the proinflammatory cytokines and IL-12p40 *resulted* in elevated CD4+ T cell activation and IFN-gamma production , which enhanced macrophage effector functions and reduced bacterial loads . Negative_regulation IL2RA CAPN8 11585637 866122 Inhibiting *caused* a dose dependent inhibition of [CD25] cell surface expression and also inhibited expression shortly after activation and for at least 48 h . Negative_regulation IL2RA IL1B 11758206 887634 The expression of , IL-4 , IL-10 , IFN gamma was up-regulated , and the expression of IL-2 , [CD25] , IL-5 , IL-6 , TNF alpha was significantly *inhibited* in group A . Negative_regulation IL2RA SELL 19635034 2118538 Expression of CA-AhR in donor T-cells enhanced the down-regulation of on Day 2 after injection , similar to a single oral dose of TCDD , but did not *induce* up-regulation of [CD25] on Day 2 or affect CTL activity on Day 10 . Negative_regulation IL2RA TNF 11522182 852737 HIV type 1 Tat inhibits alpha *induced* repression of tumor necrosis factor receptor [p55] and amplifies tumor necrosis factor alpha activity in stably tat transfected HeLa Cells . Negative_regulation IL2RA TNF 16387162 1494290 Compared to CsA therapy , increased TRL concentrations did not further inhibit PCNA expression , inhibited [CD25] expression less on days 1 and 2 and equally high on day 3 , but *inhibited* expression of IL-2 and significantly higher on days 2 and 3 ( P < .05 ) . Negative_regulation IL2RA TNF 2318252 130249 More interestingly , significantly *increased* the number of high-affinity [IL2R] on purified T cells in the presence of phorbol 12,13-dibutyrate . Negative_regulation IL2RB CAPN8 15264225 1275169 NGF acts via [p75] low-affinity neurotrophin receptor and *inhibition* to reduce UV neurotoxicity . Negative_regulation IL2RB TNF 2318252 130250 More interestingly , significantly *increased* the number of high-affinity [IL2R] on purified T cells in the presence of phorbol 12,13-dibutyrate . Negative_regulation IL2RG TNF 2318252 130251 More interestingly , significantly *increased* the number of high-affinity [IL2R] on purified T cells in the presence of phorbol 12,13-dibutyrate . Negative_regulation IL3 KLF9 14976188 1236251 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL3 TLR7 20677943 2305580 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL3 TNF 10813532 693301 In the presence of IL-11 , [IL-3] , SLF , and Tpo , CFU-MK derived from CB , mPBL , and BM was *suppressed* by and transforming growth factor-beta1 ( TGF-beta1 ) . Negative_regulation IL3 TNF 1698795 141626 Specificity studies under conditions that prevent receptor internalization showed that the binding of [IL-3] , GM-CSF , and IL-5 was not *inhibited* by , IL-1 beta , interferon (IFN)-gamma , or G-CSF . Negative_regulation IL3 TNF 8833901 386005 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL3 TNF 8957229 401628 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL3 TNF 9122614 423992 The expression of GM-CSF- , [IL-3-] or M-CSF induced Fc epsilon RII on the surface of monocytes was *reduced* by . Negative_regulation IL3 TNF 9122614 423994 The present analysis was designed to examine whether or not could *suppress* GM-CSF- , [IL-3-] or M-CSF induced Fc epsilon RII messenger RNA ( mRNA ) expression and enhance the release of sFc epsilon RII induced by these cytokines . Negative_regulation IL3 TNF 9122614 423996 These results suggest that *dependent* reduction of GM-CSF- , [IL-3-] or M-CSF induced Fc epsilon RII expression on the surface of monocytes resulted , at least in part , from the suppression of Fc epsilon RII mRNA and the enhancement of sFc epsilon RII release . Negative_regulation IL3 TNF 9126704 426578 These results demonstrate that PGE2 does not affect LT-beta , IL-4 , or [IL-3] in Th2 cells , but *inhibits* mRNA accumulation and production in this T cell subset . Negative_regulation IL31 KLF9 14976188 1236047 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL31 TLR7 20677943 2305460 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL31 TNF 8833901 385993 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL31 TNF 8957229 401616 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL32 FAS 21321117 2410758 Flow cytometry analysis revealed that overexpression of [IL-32a] *induced* increased expression of and UL16 binding protein 2 (ULBP2) in CML cells . Negative_regulation IL32 KLF9 14976188 1235996 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL32 TLR7 20677943 2305430 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL32 TNF 8833901 385990 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL32 TNF 8957229 401613 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL33 KLF9 14976188 1235979 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL33 TLR7 20677943 2305420 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL33 TNF 8833901 385989 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL33 TNF 8957229 401612 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL34 KLF9 14976188 1236064 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL34 TLR7 20677943 2305470 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL34 TNF 8833901 385994 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL34 TNF 8957229 401617 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL37 KLF9 14976188 1235945 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL37 TLR7 20677943 2305410 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL37 TNF 8833901 385988 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL37 TNF 8957229 401611 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL4 ARSA 11238116 790482 *inhibited* [IL-4] , but not IL-2 , promoter-driven chloramphenicol acetyltransferase expression in transiently transfected Jurkat T cells . Negative_regulation IL4 ARSA 20304104 2254847 Finally , <5-ASA> *inhibited* both OVA-specific IgE antibody and [IL-4] production ; Negative_regulation IL4 CD14 7691031 228707 [IL-4] *induces* down-regulation of expression on human monocytes only when the cells are cultured with serum . Negative_regulation IL4 CST6 11238649 790884 mRNA expression and flow cytometric analysis of infected spleen cells suggested that and IFN-gamma treatment , in addition to greatly reducing parasite numbers , *resulted* in reduced levels of [IL-4] but increased levels of IL-12 and inducible NO synthase . Negative_regulation IL4 EPHB2 12594266 1060829 However , reduction of activity *led* to a dramatic increase in [IL-4] production and Th2 generation . Negative_regulation IL4 EPHB2 12594266 1060838 In addition , these data suggest that TCR induced activation is *involved* in the regulation of [IL-4] expression by altering the composition of the AP-1 complex and its subsequent DNA binding activity . Negative_regulation IL4 EPHB2 12594849 1061103 or JNKinhibitors partially *inhibited* [IL-4] and IL-10 secretion , while PKC or p38 inhibitors had no significant effects on IL-4 or IL-10 secretion . Negative_regulation IL4 HRH1 15021962 1221739 Depletion of the *resulted* in decreases in the release of IL-2 and IL-10 from both CD4+ and CD8+ cells and increases in the release of [IL-4] from CD4+ T cells and IFN-gamma from CD8+ cells . Negative_regulation IL4 IL1B 10954049 724515 Production of tumor necrosis factor (TNF)-alpha and by mouse mesangial cells was not blocked by SSA but production of [IL-4] by these cells was *inhibited* by it ( > 0.1 mM ) . Negative_regulation IL4 IL1B 15930749 1414599 Both CHD and MCHD also potently reduced the mRNA levels of cyclooxygenase (COX)-2 , interferon (IFN)-gamma and [IL-4] increased in oxazolone applied mouse ears , but weakly *inhibited* that of and TNF-alpha . Negative_regulation IL4 IL1B 18025126 1827597 The CCL20 production by synoviocytes is augmented in vitro by , IL-17 , or tumor necrosis factor alpha , and is *suppressed* by IFN-gamma or [IL-4] . Negative_regulation IL4 IL1B 7594531 334794 [IL-4] expression in human T cells is selectively *inhibited* by IL-1 alpha and . Negative_regulation IL4 IL1B 7594531 334796 IL-1 alpha and *inhibited* [IL-4] production by 20 to 80 % in > 92 % of healthy individuals ( p = 0.0001 , paired t-test ) . Negative_regulation IL4 IL1B 9705828 526088 Furthermore , *inhibited* [IL-4] induced VCAM-1 expression , which was also reversed by COX-2 inhibition . Negative_regulation IL4 KLF9 14976188 1236268 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL4 PCSK9 18721197 1979921 also *suppressed* [IL-4] and TNF-alpha expression in the ears and mast cell infiltration into the ears in NC/Nga mice . Negative_regulation IL4 PCSK9 18721197 1979922 Further study demonstrated that *inhibited* ConA induced [IL-4] secretion and LPS induced macrophage activation . Negative_regulation IL4 RAB31 7876537 298723 The experiments reported here indicate that also *inhibited* the expression of [IL-4] , IL-6 , and IL-10 , thereby raising the possibility that the blockade of IL-9 production by anti-IL-2R mAb could be secondary to the blockade of these cytokines . Negative_regulation IL4 TLR7 20677943 2305590 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL4 TNF 10227996 610533 However , [IL-4] still *induced* significant inhibition of the production of and IL-12 from STAT6 null macrophages that were stimulated with the more physiologically relevant combination of LPS and IFN-gamma . Negative_regulation IL4 TNF 10233738 611571 The failure of [IL-4] to regulate IL-10 production is not *due* to the failure of IL-4 to suppress , and vice versa . Negative_regulation IL4 TNF 10540171 563258 Interestingly , MTX did not *enhance* [IL-4] production when present during restimulation of effector CD45RO T cells , although it still suppressed production . Negative_regulation IL4 TNF 10954049 724514 Production of and IL-1beta by mouse mesangial cells was not blocked by SSA but production of [IL-4] by these cells was *inhibited* by it ( > 0.1 mM ) . Negative_regulation IL4 TNF 12193748 981560 HAT partially inhibited production of and completely *inhibited* production of [IL-4] , IL-5 , and IL-10 . Negative_regulation IL4 TNF 12826081 1104536 GXM *enhanced* the secretion of IL-10 and [IL-4] , while it reduced the production of pro-inflammatory cytokines and IFN-gamma . Negative_regulation IL4 TNF 16078585 1442532 The results indicated that thalidomide treatment significantly reduced colonic inflammation , suppressed NF-kappaB activation , enhanced TNF-alpha mRNA degradation , *inhibited* the synthesis of the , IEN-gamma and increased the production of [IL-4] . Negative_regulation IL4 TNF 17045026 1635693 IL-7 and IL-15 could affect the balance between Th1 and Th2 cytokines by inducing IFN-gamma and production and *inhibiting* [IL-4] and IL-10 expression . Negative_regulation IL4 TNF 17261545 1710490 Anti-FasL , but not or anti-TRAIL , *blocked* activation induced cell death of CD8 T cells and increased secretion of IL-10 and [IL-4] by CD4 T cells from T. cruzi infected mice . Negative_regulation IL4 TNF 18178046 1869961 Different dilutions of Sayali olive oil dose-dependently inhibited the production of and interleukin-4 (IL-4) , and different dilutions of Zarrazi olive oil dose-dependently *inhibited* histamine release and [IL-4] production by calcium ionophore A23187 plus phorbol 12-myristate 13-acetate ( PMA ) -stimulated KU812 cells . Negative_regulation IL4 TNF 19703147 2133357 Urocortin treatment *induced* a significant and dose dependent increase of [IL-4] and IL-10 , whereas it did not affect secretion . Negative_regulation IL4 TNF 7594531 334797 IL-12 had an inhibitory effect on PBMC IL-4 production as previously described , but neither IL-6 nor *inhibited* [IL-4] production . Negative_regulation IL4 TNF 8742066 377135 LPS stimulated release of declined substantially after the first day and was consistently *suppressed* by IL-10 and [IL-4] but increased by IFN-gamma . Negative_regulation IL4 TNF 8833901 386006 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL4 TNF 8957229 401629 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL4 TNF 9002955 410527 and IL-6 enhanced IFN-gamma production , but *suppressed* [IL-4] production in the cultures . Negative_regulation IL4 TNF 9126704 426579 These results demonstrate that PGE2 does not affect LT-beta , [IL-4] , or IL-3 in Th2 cells , but *inhibits* mRNA accumulation and production in this T cell subset . Negative_regulation IL4 TNF 9927530 588642 We investigated the *role* of in the regulation of MHC class II antigens and cytokine mRNA expression of TNF , interferon-gamma (IFN) , IL-2 , [IL-4] , and IL-10 in cardiac allografts to elucidate its immunological mechanism . Negative_regulation IL4 TNFSF10 17261545 1710491 Anti-FasL , but not anti-TNF-alpha or , *blocked* activation induced cell death of CD8 T cells and increased secretion of IL-10 and [IL-4] by CD4 T cells from T. cruzi infected mice . Negative_regulation IL5 ADRB2 15879418 1432947 Desensitization of ( - ) -isoproterenol induced cyclic adenosine monophosphate ( cAMP ) accumulation and beta(2)-adrenergic receptor sequestration and downregulation were measured in relation to *mediated* inhibition of IFN-gamma and [interleukin-5] production . Negative_regulation IL5 CST6 23174104 2740866 Ex vivo restimulation with cystatin of spleen cells from cystatin treated mice induced the production of IL-10 , while *inhibited* allergen-specific [IL-5] and IL-13 levels . Negative_regulation IL5 ITGAL 3509923 84598 The [B151-TRF2] responses of purified B cells obtained from athymic nude mice were specifically *inhibited* by the relevant anti-I-A mAb but not by anti-L3T4 and mAbs , both of which were inhibitory to the Ia-restricted T cell responses . Negative_regulation IL5 KLF9 14976188 1236285 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL5 TLR7 20677943 2305600 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL5 TNF 12193748 981561 HAT partially inhibited production of and completely *inhibited* production of IL-4 , [IL-5] , and IL-10 . Negative_regulation IL5 TNF 1698795 141629 Specificity studies under conditions that prevent receptor internalization showed that the binding of IL-3 , GM-CSF , and [IL-5] was not *inhibited* by , IL-1 beta , interferon (IFN)-gamma , or G-CSF . Negative_regulation IL5 TNF 21402950 2411945 Also , lack of decreased IL-17A but *promoted* [IL-5] levels , switching inflammation from a neutrophil to eosinophil bias resembling that in C57BL/6 mice . Negative_regulation IL5 TNF 8833901 386007 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL5 TNF 8957229 401630 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL6 ABCA4 11809739 906507 The elicited a reciprocal response , i.e. elevated IL-12 and NO production , and *reduced* [IL-6] and IL-10 production . Negative_regulation IL6 BPI 8063410 268740 also *inhibited* LPS induced tumor necrosis factor alpha , IL-1 beta , and [IL-6] release from human whole blood . Negative_regulation IL6 BPI 8409400 233338 LBP was shown to *enhance* LPS induced TNF-alpha , [IL-6] , and IL-8 release by mononuclear phagocytic cells , whereas inhibited the release of these cytokines . Negative_regulation IL6 CD14 20946675 2337964 Blocking in monocytes *inhibited* secretion of interleukin (IL)-1ß ( 72 % ) , [IL-6] ( 58 % ) and IL-10 ( 63 % ) , and blocking TLR4 inhibited secretion of IL-1ß by 67 % , IL-6 by 63 % and IL-10 by 60 % . Negative_regulation IL6 CTGF 23827951 2820810 stimulation *resulted* in the significant production of [IL-6] , IL-8 , C-C motif ligand 2 (CCL2) , CCL20 , MMP-1 and MMP-3 in FLSs in the presence , but not in the absence , of IL-1ß . Negative_regulation IL6 EDN2 11997273 939333 antagonism and [interleukin-6] *inhibition* attenuate the proatherogenic effects of C-reactive protein . Negative_regulation IL6 EDN2 11997273 939339 In each study , the effect of antagonism ( bosentan ) and [IL-6] *inhibition* ( monoclonal anti-IL-6 antibodies ) was examined . Negative_regulation IL6 EPHB2 17644731 1798833 This study was undertaken to elucidate the mechanisms underlying anti-beta2M mAb induced PI3K/Akt and *inhibition* and the inability of [IL-6] and IGF-I to protect myeloma cells from mAb induced apoptosis . Negative_regulation IL6 EPHB2 20161729 2215148 Berberine significantly *inhibited* HIV PI-induced TNF-alpha and [IL-6] expression by modulating ER stress signaling pathways and subsequent activation , in turn preventing the accumulation of the RNA binding protein HuR in cytosol and inhibiting the binding of HuR to the 3'-UTRs of TNF-alpha and IL-6 in macrophages . Negative_regulation IL6 FAS 18593565 1953601 The present study characterizes the molecular mechanisms of *induced* inhibition of [IL-6] signaling , which is known to mediate hepatoprotective effects in response to various toxins . Negative_regulation IL6 FAS 9694512 523721 Together , our data support the notion that the decrease in IL-3 induced histamine and [IL-6] production by splenocytes pretreated with anti-CD3 is *mediated* , at least in part , by interactions , suggesting that the activity of extramedullary myeloid precursor cells can be modulated by molecules involved in apoptosis . Negative_regulation IL6 FOLR1 22327861 2586506 Meanwhile , did not *inhibit* the cyclooxigenase 2 , [interleukin-6] , and nuclear factor kappa B transcription . Negative_regulation IL6 FUT4 10440571 635347 The productions of both [IL-6] and IL-8 , measured by enzyme linked immunosorbent assay , were significantly *inhibited* by at the concentration of 1 to 100 microg/ml in a dose dependent manner . Negative_regulation IL6 FUT4 10440571 635369 Furthermore , the expressions of [IL-6] and IL-8 mRNAs were also *inhibited* by . Negative_regulation IL6 GLP1R 24048027 2846358 activation in the mouse neuronal Neuro2A cell line also *resulted* in increased [IL-6] expression . Negative_regulation IL6 GPNMB 17475886 1738536 overexpression in RAW264.7 cells *caused* a 2-fold reduction in the production of the cytokines [IL-6] and IL-12p40 and the inflammatory mediator NO in response to LPS . Negative_regulation IL6 HBEGF 23393916 2713222 [IL-6] production in 3T3-L1 adipocytes was markedly increased by CS stimulus , and the enhanced secretion of IL-6 was *suppressed* in a dose dependent manner by . Negative_regulation IL6 HES2 15836676 1397663 significantly *reduced* the increased hepatic levels of TNF-alpha , IL-1beta , [IL-6] , IL-8 and the mRNAs in the endotoxemic rats . Negative_regulation IL6 HES2 16104441 1444700 significantly *reduced* the LPS induced increase in intestinal levels of TNF-alpha , IL-1beta , [IL-6] , IL-8 and their corresponding mRNAs . Negative_regulation IL6 HES2 16790644 1578627 significantly *reduced* the increased intestinal levels of tumor necrosis factor-alpha , [IL-6] , cytokine induced neutrophil chemoattractant-1 , and the mRNAs in the endotoxemic rats . Negative_regulation IL6 HES2 19166983 2038547 In addition , both and BL could *attenuate* the increase in TNF-alpha , [IL-6] , MPO levels and NF-kappaB activation . Negative_regulation IL6 HES2 19766237 2224569 dose-dependently *reduced* the plasma level of TNF-alpha and [IL-6] in rats with sepsis . Negative_regulation IL6 HES2 20451670 2288424 Meanwhile , could significantly *reduce* TNF-alpha , [IL-6] , and ICAM-1 mRNA , inhibit NF-kappaB activation , and down-regulate TLR2 and TLR4 expression in the brain . Negative_regulation IL6 HSD11B2 19776225 2232015 In contrast , overexpression of <11 beta-HSD1> further *augmented* TNF-alpha induced iNOS , [IL-6] , and MCP-1 expression . Negative_regulation IL6 IFI27 10951574 723723 Inhibition of MEK activation completely abrogated OSM and [IL-6] *induced* p27kip1 accumulation , while expression of dominant negative STAT5 decreased the OSM and IL-6 mediated inhibition of DNA-synthesis and partially inhibited accumulation . Negative_regulation IL6 IL1B 10219249 609099 ( 3 ) adding rIL-10 or neutralizing endogenous and TNF-alpha *down-regulated* [IL-6] mainly by destabilizing IL-6 transcripts , whereas exogenous IL-4 and TGF beta 1 down-regulated IL-6 transcriptionally ; Negative_regulation IL6 IL1B 10405202 629291 Stimulation with lipopolysaccharide and *resulted* in the full induction of [IL-6] expression only if the cells were coincubated with cAMP agonists ; Negative_regulation IL6 IL1B 10467171 640690 Stimulation with *resulted* in the production of [IL-6] and prostaglandin E ( 2 ) ( PGE ( 2 ) ) . Negative_regulation IL6 IL1B 10482376 643828 [IL-6] did not alter NIS functional activity , but *suppressed* iodide accumulation by approximately 25 % . Negative_regulation IL6 IL1B 10807012 692159 Stimulation of the Caco-2 cells with *resulted* in increased mRNA levels for C3 and [IL-6] with no major differences noted when the cells were treated at the apical or basolateral membrane . Negative_regulation IL6 IL1B 11048965 743162 The anti-inflammatory drug , dexamethasone ( 1 microM ) , abolished the production of both [IL-6] and IL-8 in gingival fibroblasts challenged with PHT in the *presence* or absence of . Negative_regulation IL6 IL1B 11071643 748131 *inhibits* [interleukin 6-mediated] rat gamma fibrinogen gene expression . Negative_regulation IL6 IL1B 11446462 835391 Regulatory *role* of in the expression of [IL-6] and IL-8 in human corneal epithelial cells during Pseudomonas aeruginosa colonization . Negative_regulation IL6 IL1B 11777983 899885 Furthermore , IL-17 , , and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs , and specific MAPK inhibitors ( SB203580 , PD98059 , and U0216 ) significantly *reduced* IL-17- , IL-1beta- , or TNF-alpha induced [IL-6] secretion , indicating the role of MAPKs in the induction of IL-6 . Negative_regulation IL6 IL1B 11842936 912365 Indomethacin , a cyclooxygenase inhibitor , significantly *enhanced* IL-1beta induced [IL-6] production by HGF , although it completely inhibited induced PGE2 production . Negative_regulation IL6 IL1B 12045890 895167 The *role* of in the regulation of IL-8 and [IL-6] in human corneal epithelial cells during Pseudomonas aeruginosa colonization . Negative_regulation IL6 IL1B 12957790 1137952 Whereas the signal *induced* a decrease in [IL-6] expression and release of normoxic neurones , it provoked an increase in IL-6 protein in hypoxic neurones . Negative_regulation IL6 IL1B 1404130 199616 In contrast , flurbiprofen completely abolished [IL-6] production by both cell lines and substantially *inhibited* and TNF alpha production . Negative_regulation IL6 IL1B 1431212 202867 stimulation *resulted* in pronounced [IL-6] production after 4 h , followed by complete downregulation at the transcriptional level after 24 h . Negative_regulation IL6 IL1B 16354411 1492517 Licochalcone A ( IC50 15.0 nM ) inhibited PGE2 production , but not [IL-6] and IL-8 production , in *response* to . Negative_regulation IL6 IL1B 1730872 181334 We have previously reported that transforming growth factor-beta inhibits [IL-6] production in *response* to . Negative_regulation IL6 IL1B 17698652 1782300 Here , it is reported that both wild-type and mutant IE2p86 can block activation of the [IL-6] promoter in *response* to . Negative_regulation IL6 IL1B 18248759 1877160 Uropathogenic E. coli prevented [interleukin-6] secretion in *response* to non-pathogenic E. coli and a panel of Toll-like receptor agonists , as well as to , but not to tumor necrosis factor alpha . Negative_regulation IL6 IL1B 18480275 1910669 Consistently , TNFalpha and enhanced AMPA- or NMDA induced currents , and IL-1beta and [IL-6] *suppressed* GABA- and glycine induced currents . Negative_regulation IL6 IL1B 19181383 2049299 Ablation of IRAK-4 expression in human umbilical vein endothelial cells ( HUVEC ) with siRNA suppressed IL-1beta *induced* [IL-6] and IL-8 production whereas IRAK-1 siRNA suppressed TNFalpha induced but not induced cytokine production . Negative_regulation IL6 IL1B 19406240 2095652 In PC-3 cells , IL-1beta stimulated [IL-6] and OPG release , and dexamethasone dose-dependently *inhibited* IL-1beta-inducible IL-6 release , and constitutive and OPG release . Negative_regulation IL6 IL1B 19580863 2142567 *Role* of and COX2 in silica induced [IL-6] release and loss of pneumocytes in co-cultures . Negative_regulation IL6 IL1B 20456417 2288480 In the presence of LPS , LcS enhanced production but *inhibited* LPS induced IL-10 and [IL-6] production , and had no further effect on TNF-alpha and IL-12 production . Negative_regulation IL6 IL1B 8033802 264127 Vasopressin and oxytocin ( 1 microM ) inhibited LPS and stimulation of IL-6 release from NIL cells , but did not *inhibit* [IL-6] release from AP cells . Negative_regulation IL6 IL1B 9334851 457932 Lipopolysaccharide (LPS) induced in vitro TNF-alpha production by human peripheral blood mononuclear cells , measured by enzyme linked immunosorbent assay ( ELISA ) , was significantly inhibited with more than 1 x 10 ( -3 ) mol/l of nicotinamide , while was not inhibited and [interleukin-6] was slightly *inhibited* even with 10 ( -2 ) mol/l. Oral administration of nicotinamide with more than 62.5 mg/kg also significantly inhibited LPS induced serum TNF-alpha production measured by ELISA and bioassay in Balb/c mice . Negative_regulation IL6 IL1B 9695734 524381 Both TNF alpha and may be *involved* in the regulation of gastrointestinal [IL-6] production during endotoxemia . Negative_regulation IL6 IL6R 1321736 192043 We studied the *role* of in binding , internalization and down-regulation of the hepatic [IL6-receptor (IL6R)] by its ligand in human hepatoma cells ( HepG2 ) . Negative_regulation IL6 IL6R 17024100 1674279 *Induction* of [IL-6] by IL-1beta peptide and stimulation by IL-6 peptide in NFs , or inhibition of IL-6 or in KFs cultures demonstrated a dose dependent increase or decrease in procollagen I synthesis , respectively . Negative_regulation IL6 IL6R 23372742 2739187 These elevated levels may *contribute* to increased [interleukin-6] activity through the trans signaling pathway . Negative_regulation IL6 IL6R 9110148 425009 All the *inhibited* wild-type [IL-6] . Negative_regulation IL6 KLF9 14976188 1236302 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL6 KRT38 9614214 509502 Interestingly , K-37 and could *suppress* the production of tumor necrosis factor alpha and [interleukin 6] in phytohemagglutinin stimulated peripheral blood mononuclear cells and the expression of intercellular adhesion molecule 1 in tumor necrosis factor alpha stimulated human umbilical vein endothelial cells at their nontoxic concentrations . Negative_regulation IL6 MAP2K6 14573621 1186477 In contrast , inhibitors of protein kinase A or C , , and phosphoinositide 3-kinase *had* no effect on [IL-6] mRNA levels . Negative_regulation IL6 MAP2K6 18252806 1895850 Interestingly , , p38 , and IKK inhibitors *block* TNF-alpha induced IL-8 , [IL-6] , and GM-CSF secretion and 12z invasion , whereas the PI3K inhibitors do not . Negative_regulation IL6 RAB31 7876537 298751 The experiments reported here indicate that also *inhibited* the expression of IL-4 , [IL-6] , and IL-10 , thereby raising the possibility that the blockade of IL-9 production by anti-IL-2R mAb could be secondary to the blockade of these cytokines . Negative_regulation IL6 RGS2 11996904 939187 We found that overexpression significantly *inhibited* [IL-6] promoter activity following fluprostenol treatment , but not following PTH treatment . Negative_regulation IL6 RORC 20015694 2204421 IFN-alpha did not affect the production of TGF-beta or [IL-6] , but *inhibited* mRNA expression of anti-CD3 stimulated CD4+ T cells . Negative_regulation IL6 S100B 10617115 656433 The low levels of S100beta required to induce IL-6 overexpression in neurons , shown here , suggest that overexpression of *induces* neuronal expression of [IL-6] and of IL-6 induced neurodegenerative cascades in Alzheimer 's disease . Negative_regulation IL6 SPHK1 17686057 1781486 Although sphingosine kinase (SPHK) signalling is known to play important roles in the regulation of cell proliferation and apoptosis , the *role* of activation in [IL-6] signalling and in the pathology of MM remains unclear . Negative_regulation IL6 TLR7 17054926 1642066 Ligand activation of TLR2 , TLR4 and TLR5 , but not TLR3 , or TLR9 , *resulted* in cardiomyocyte expression of the inflammatory cytokine [IL-6] , the chemokines KC and MIP-2 , and the cell surface adhesion molecule ICAM-1 . Negative_regulation IL6 TLR7 17918201 1819360 In this study , we investigated which mouse B cell subsets are the most potent cytokine producers , and examined the *role* of in the control of secretion of [IL-6] , IL-10 , IL-12 and IFN-gamma by B cells . Negative_regulation IL6 TLR7 18271077 1865812 Stimulation with TLR2 , TLR4 and ligands , as well as TLR3 ligand , *resulted* in significantly lower production of TNF-alpha , but neither [IL-6] nor IL-12p70 , by DCs from XLA patients in comparison to normal controls . Negative_regulation IL6 TLR7 20677943 2305610 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL6 TLR7 20730378 2313300 Selective inhibitors of Kv11 .1 regulate [IL-6] expression by macrophages in *response* to ligands . Negative_regulation IL6 TLR7 21914077 2479383 We previously showed that chronic exposure to the core antigen induces hyporesponsiveness to TLR ligands in antigen presenting cells via activation of TLR2 and that stimulation with ligands *results* in impaired [IL-6] production by peripheral blood monocytes from HCV infected patients . Negative_regulation IL6 TLR7 22751696 2670343 ligation also *resulted* in a diminished [IL-6] response in seropositive individuals as lower frequencies of IL-6 expressing monocytes and mDCs were induced . Negative_regulation IL6 TNF 10037006 557543 However , the role of monoclonal antibodies , directed against these factors , confirmed the *role* of in the [IL-6] production by stromal cells , while any IL-1beta intervention was not shown in our co-culture system . Negative_regulation IL6 TNF 10201958 605715 We have observed that NGF at doses as low as 10 ng/ml will induce [IL-6] production and *inhibit* release from rat peritoneal mast cells in the presence of lysophosphatidylserine as a cofactor . Negative_regulation IL6 TNF 10219249 609098 ( 3 ) adding rIL-10 or neutralizing endogenous IL-1 beta and *down-regulated* [IL-6] mainly by destabilizing IL-6 transcripts , whereas exogenous IL-4 and TGF beta 1 down-regulated IL-6 transcriptionally ; Negative_regulation IL6 TNF 10319886 612052 Conversely , treatment of PBMCs with the adenosine A1 receptor agonist R-phenylisopropyladenosine (R-PIA) ( 1 microM ) significantly inhibited mitogen stimulated production of TNF alpha but not [IL-6] in control subjects and significantly *inhibited* production of IL-6 but not in MS patients . Negative_regulation IL6 TNF 10469353 641198 Using renal resident macrophage cells treated with endotoxin , lipopolysaccharide (LPS) , and beta2-adrenoceptor agonist , terbutaline , we investigated the *role* of cAMP pathway , and mitogen activated protein kinase (MAPK) pathway ( p42/p44 ) in regulating [IL-6] production . Negative_regulation IL6 TNF 10469353 641213 The terbutaline induced down-regulation of [IL-6] gene production was *mediated* by an inhibitory effect of terbutaline on , which was exerted through the MAPK and cAMP pathways , whereas the up-regulation appeared to be due to a direct action of intracellular cAMP . Negative_regulation IL6 TNF 10569696 568026 We conclude that Th2-type cytokines IL-4 and IL-13 affect the release of [IL-6] by HBECs in *response* to ( inhibition ) and IFgamma ( augmentation ) . Negative_regulation IL6 TNF 10877831 708908 Bacteria reversed noradrenergic inhibitory effector mechanisms : Under bacteria-free conditions , secretion was very low and [IL-6] secretion was mainly *inhibited* by alpha2-adrenoreceptor ligation . Negative_regulation IL6 TNF 10877831 708909 In the presence of bacteria , and IL-6 secretion were high and [IL-6] secretion was mainly *inhibited* by beta-adrenoreceptor ligation . Negative_regulation IL6 TNF 11071876 748650 Using neutrophils from EP2- and EP4-deficient mice in combination with EP2- and EP4-selective agonists , it was found that the augmentation of [IL-6] was *mediated* mainly by the EP2 receptor and the suppression of by the EP4 receptor and partially by the EP2 receptor . Negative_regulation IL6 TNF 11134960 769693 gene expression was also dramatically reduced by SNP , but [IL-6] gene expression was *inhibited* much less . Negative_regulation IL6 TNF 11446746 835433 We recently found that CGRP induces [IL-6] and TNF-alpha in long-term bone marrow cultures and that IL-6 and also *inhibit* IL-7 responses . Negative_regulation IL6 TNF 11562425 862785 Pretreatment of ASM cells with SB203580 , a p38 MAPK inhibitor , slightly enhanced induced ICAM-1 expression in a dose dependent manner but partially *inhibited* secretion of RANTES and [IL-6] . Negative_regulation IL6 TNF 11777983 899883 Furthermore , IL-17 , IL-1beta , and induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs , and specific MAPK inhibitors ( SB203580 , PD98059 , and U0216 ) significantly *reduced* IL-17- , IL-1beta- , or TNF-alpha induced [IL-6] secretion , indicating the role of MAPKs in the induction of IL-6 . Negative_regulation IL6 TNF 11964604 932793 After HX-XO administration , was reliably detected at 60 min and interleukin-6 at 90 min. Simultaneous infusion of isoproterenol *inhibited* TNF-alpha and [interleukin-6] release . Negative_regulation IL6 TNF 12017175 942398 IL-10 inhibited IL-8 mRNA expression , which is normally stimulated by PiLPS , IL-1alpha , and and *inhibited* [IL-6] mRNA expression , which is normally stimulated by IL-1alpha . Negative_regulation IL6 TNF 12023001 943481 During the 24-hour postoperative period , GGA significantly suppressed the release of aspartate or alanine aminotransferase and elevation of the serum [interleukin-6] level , and completely *inhibited* an increase in the serum level of . Negative_regulation IL6 TNF 12869027 1112134 IgG prevented induced CD106 membrane expression and an increase in [ Ca++]i , and *inhibited* the secretion of [interleukin-6 (IL-6)] and macrophage-colony stimulating factor ( M-CSF ) . Negative_regulation IL6 TNF 12875587 1115133 Addition of RXM at a concentration of 10.0 microg/ml to cell cultures suppressed both [IL-6] and RANTES ( but not IL-8 ) production in *response* to stimulation with 25.0 ng/ml . Negative_regulation IL6 TNF 1404130 199615 In contrast , flurbiprofen completely abolished [IL-6] production by both cell lines and substantially *inhibited* IL-1 beta and production . Negative_regulation IL6 TNF 14734475 1199280 However , in the resistant cells , the production of IL-1beta and [IL-6] were specifically impaired in *response* to . Negative_regulation IL6 TNF 15531521 1336084 Stimulation of placenta , adipose tissue , and skeletal muscle with LPS and *resulted* in greater release of [IL-6] and IL-8 , whereas only LPS increased TNF-alpha release from all three tissues . Negative_regulation IL6 TNF 16906639 1632740 In the *presence* of , culture with CCE ( 10-100 microg/mL ) for 48 h inhibited the production of [IL-6] and nitric oxide in osteoblastic MC3T3-E1 cells . Negative_regulation IL6 TNF 16988225 1617887 Although alpha production was reduced in mice infected with the mutant of devoid LOS , both LOS mutants *induced* production of other proinflammatory cytokines , such as interleukin-1beta (IL-1beta) , [IL-6] , and the murine IL-8 homolog KC. Together , these results suggest that meningococcal LOS plays a role during the early infectious and invasive process , and they further confirm that other , nonlipopolysaccharide components of Neisseria meningitidis may significantly contribute to the inflammatory reaction of the host . Negative_regulation IL6 TNF 1730779 181318 stimulates DNA synthesis of mouse hepatocytes in primary culture and is *suppressed* by transforming growth factor beta and [interleukin 6] . Negative_regulation IL6 TNF 18314542 1931914 SB203580 + , t(1/2) = 1.5 h ) , exogenous expression of MKP-1 significantly *inhibits* TNF-alpha induced [IL-6] secretion and MKP-1 siRNA reverses the inhibition of TNF-alpha induced IL-6 secretion by dexamethasone . Negative_regulation IL6 TNF 18349186 1887038 The mu opioid receptor mediates morphine induced and [interleukin-6] *inhibition* in toll-like receptor 2-stimulated monocytes . Negative_regulation IL6 TNF 18480275 1910668 Consistently , and IL-1beta enhanced AMPA- or NMDA induced currents , and IL-1beta and [IL-6] *suppressed* GABA- and glycine induced currents . Negative_regulation IL6 TNF 19060786 2105764 Intravenous LPS ( 10-50 mg/kg ) dose-dependently increased plasma endotoxin and reactive oxygen species in the blood , bile , and liver and increased plasma alanine aminotransferase and aspartate aminotransferase levels as well as , monocyte chemoattractant protein 1 , tissue *inhibitor* of metalloproteinase 1 , IL-1beta , and [IL-6] levels in the rats . Negative_regulation IL6 TNF 1918983 168456 Taken together , results reported here provide evidence that functional interaction between IFN-gamma and is *involved* in the regulation of [IL-6] and IL-6R expression in monocytic cells . Negative_regulation IL6 TNF 19528220 2121081 Further , adding autolyzed pneumococci to intact bacteria inhibited production of , IFN-gamma , and IL-12 in a dose dependent manner but did not *inhibit* production of [IL-6] , IL-8 , and IL-10 in response to the intact bacteria . Negative_regulation IL6 TNF 19580863 2142573 In this study we investigated the *role* of IL-1 beta , and COX2 in silica induced regulation of [IL-6] release and pneumocyte loss in various mono- and co-cultures of monocytes , pneumocytes and endothelial cells . Negative_regulation IL6 TNF 19583958 2162564 SB202190 successfully suppressed [IL-6] , IL-8 , PGE2 , and PGF2alpha secretion in macrophage exposed AF cells in *response* to . Negative_regulation IL6 TNF 19710092 2319434 Removal of from the THP-1 culture supernatant prior to HUVEC stimulation *resulted* in a decrease in NF-?B activity , expression of adhesion molecules , as well as [IL-6] secretion . Negative_regulation IL6 TNF 19774506 2202818 These results suggest that the anti-inflammatory properties of madecassic acid are caused by iNOS , COX-2 , , IL-1beta , and [IL-6] *inhibition* via the downregulation of NF-kappaB activation in RAW 264.7 macrophage cells . Negative_regulation IL6 TNF 2001421 154492 *inhibits* interleukin (IL)-1 and/or [IL-6] stimulated synthesis of C-reactive protein (CRP) and serum amyloid A (SAA) in primary cultures of human hepatocytes . Negative_regulation IL6 TNF 20128155 2178930 The expression of TLR4 , and IL-6 in the myocardium significantly *increased* in the MI group and simvastatin markedly inhibits the expression of TLR4 , TNF-alpha , and [IL-6] in the myocardium after MI. Serum TNF-alpha and IL-6 levels between the MI group and the simvastatin group remained unchanged . Negative_regulation IL6 TNF 20435921 2288101 TBP and dose-dependently *inhibited* TNFalpha induced secretion of [interleukin (IL)-6] , IL-8 , granulocyte macrophage-colony stimulating factor , and monocyte chemoattractant protein-1 in immortalized human endometriotic cells . Negative_regulation IL6 TNF 20654553 655792 Chromium extract did not impair release significantly , but *inhibited* [IL-6] release significantly in stimulated PBMC . Negative_regulation IL6 TNF 21153080 407637 Serotonin ( 1-1000 nM ) increased basal [IL-6] release from zona glomerulosa cells , but *inhibited* basal release from these cells . Negative_regulation IL6 TNF 21153080 407639 Serotonin potentiated [IL-6] release stimulated by endotoxin and IL-1ß , but *inhibited* release stimulated by these agents . Negative_regulation IL6 TNF 21349589 2399580 Stimulation of endothelial monolayers with *resulted* in significant increase of toll-like receptor 4 , [interleukin-6] and -8 , and intercellular adhesion molecule-1 and vascular cellular adhesion molecule-1 gene expression in a time dependent manner . Negative_regulation IL6 TNF 21551509 2444987 1733 immunoglobulin receptors ( IgR ) of single cell sorted preswitch and postswitch memory B cells were prospectively analysed from 11 RA patients under [IL-6R] inhibition ( 7 patients ) or *inhibition* ( 4 patients ) . Negative_regulation IL6 TNF 21849156 2495957 Similarly , LPS induced increases in , IL-1ß and [IL-6] protein levels in NR8383 cell supernatants was significantly *inhibited* by MD-2 silencing . Negative_regulation IL6 TNF 21910594 2567683 IND and EP4A inhibited the upregulation of mRNA expression , and only EP4A *inhibited* [IL-6] and RANKL mRNA expressions in ST2 cells with LPS stimulation . Negative_regulation IL6 TNF 21948282 2599298 10H2DA inhibited LPS induced [IL-6] production dose-dependently , but did not *inhibit* production . Negative_regulation IL6 TNF 21952924 2539331 MI192 inhibited production at high concentrations and dose-dependently *inhibited* [IL-6] in RA PBMCs but not healthy PBMCs , across a dose range of 10 µM-5 nM . Negative_regulation IL6 TNF 22190977 2531315 Blockage of Notch signaling by a ?-secretase inhibitor ( DAPT ) inhibited [IL-6] secretion of RA FLSs in *response* to while treatment with recombinant fusion protein of Notch ligand Delta-like 1 promoted such response . Negative_regulation IL6 TNF 22953812 2667616 Fucosterol suppressed the expressions of inducible nitric oxide synthase (iNOS) , tumour necrosis factor-a (TNF-a) , and [interleukin-6 (IL-6)] by downregulating their transcriptions , and subsequently *inhibited* the productions of nitric oxide , , and IL-6 . Negative_regulation IL6 TNF 23183089 2736219 The results also found that there was significant reduction levels of IL-6 , IL-8 and in serum of CIA rats treated with ATW and ATW *inhibited* the expression of [IL-6] , IL-8 , NF-?B , TNF-a in synovial tissue . Negative_regulation IL6 TNF 23275623 2741925 Furthermore , did not elevate the intracellular Ca ( 2+ ) concentration in control or Trek-1-deficient cells , and removal of extracellular Ca ( 2+ ) did not *impair* [IL-6] release . Negative_regulation IL6 TNF 23445729 2749241 We also found that high-dose IgG specifically and completely inhibited accelerated expression of KD-related cytokines such as G-CSF , [IL-6] and IL-1ß by HCAEC in *response* to . Negative_regulation IL6 TNF 23708661 2926301 Induction of LPLUNC1 overexpression in NPC cells mitigated lipopolysaccharide (LPS) induced IL-6 , IL-8 , and IL-1ß expression or treatment of THP-1 macrophages with LPLUNC1 *inhibited* spontaneous and LPS induced [IL-6] expression in vitro . Negative_regulation IL6 TNF 23774598 2824014 [Interleukin-6 (IL-6)] was significantly inhibited in all organs , IL-1ß and IP-10 were significantly inhibited in liver , spleen , and kidneys , and , IL-8 , and PAI-1 were *inhibited* only in the spleen . Negative_regulation IL6 TNF 23799152 2802841 Knocking down WWP1 enhanced the TNF-a and [IL-6] production induced by LPS , and over-expression of WWP1 *inhibited* the and IL-6 production induced by LPS , but not by TNF-a . Negative_regulation IL6 TNF 24062615 2846668 We have demonstrated that budesonide concentration-dependently ( 10 ( -10 ) -10 ( -7 ) M ) inhibited [IL-6] , IL-8 , MMP-1 , and MMP-3 release by HFL-1 cells in *response* to IL-1ß plus . Negative_regulation IL6 TNF 7600192 311508 LPS1 significantly increased LPS2 triggered monocyte secretion of IL-1 , [IL-6] , and PGE2 , but *inhibited* release . Negative_regulation IL6 TNF 8506119 221435 However , stimulation of was absent , and that of [IL-6] was *reduced* , when the antigens were purified from detergent extracts of infected erythrocytes . Negative_regulation IL6 TNF 8598479 350724 Forskolin , an agent known to increase intracellular cAMP levels , also *induced* a significant increase in [IL-6] production , whereas production was decreased . Negative_regulation IL6 TNF 8660820 367100 When human monocytes/macrophages stimulated with silica were treated with 0.1-10 microg/ml acanthoic acid , the production of IL-1 and was inhibited up to 90 % , but the production of [interleukin-6 (IL-6)] was not *inhibited* at all . Negative_regulation IL6 TNF 8664982 368688 Dopamine increases [interleukin 6] release and *inhibits* release from rat adrenal zona glomerulosa cells in vitro . Negative_regulation IL6 TNF 8805054 382204 In contrast , stimulation of the cells with *resulted* in an equal level of [IL-6] secretion to the apical and basal surfaces , regardless of whether the cells were stimulated by the apical or basal route . Negative_regulation IL6 TNF 8833901 386008 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL6 TNF 8957229 401631 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL6 TNF 9012836 411572 Effects were selective , as induction of was unaffected and induction of [IL-6] was *enhanced* . Negative_regulation IL6 TNF 9126707 426586 Adenosine increased [IL-6] release and *inhibited* release from ovarian cells . Negative_regulation IL6 TNF 9126707 426588 Thus , in immune and endocrine tissues , adenosine increases [IL-6] release , but *inhibits* release . Negative_regulation IL6 TNF 9528954 496220 These results strongly suggest that increases the IL-6 gene expression through the activation of NF-kappaB in the thyroid cells , and that antioxidants *suppress* the TNF-alpha dependent [IL-6] expression by inhibiting the activation of the transcriptionally active NF-kappaB . Negative_regulation IL6 TNF 9695734 524380 Both and IL-1 beta may be *involved* in the regulation of gastrointestinal [IL-6] production during endotoxemia . Negative_regulation IL6 TNF 9728802 530068 The synthesis of [IL-6] was significantly *enhanced* by TNF-alpha in BMMC and ALL-T while the presence of had no effect on IL-6 synthesis in the culture of cALL leukemic cells . Negative_regulation IL6 TNF 9756751 535786 The drug also prevented [IL-6] release in lung homogenates and partly *inhibited* , but it did not interfere with IL-1alpha secretion in the lungs of infected mice . Negative_regulation IL6R CA2 8713082 373592 While depletion of from the endoplasmic reticulum *had* no effect on the degradation of [Inv-gp80sc] , it stimulated the degradation of Inv-gp80 . Negative_regulation IL6R FGB 1772437 174926 Furthermore , binding of [gp 80] to immobilized fibrinogen ( or heparin ) was inhibited in the *presence* of free ( or heparin ) added in the assay mixture . Negative_regulation IL6R FN1 1897961 167327 Binding of [gp 80] to heparin-agarose or fibrin-Sepharose , however , was inhibited in the *presence* of added or the monoclonal antibody . Negative_regulation IL6R IL6 1321738 192047 Stable transfection of into HepG2 cells ( HepG2-IL-6 ) resulting in constitutive secretion of 2 micrograms of IL-6 per 10 ( 6 ) cells in 24 h *led* to a down-regulation of surface bound [gp80] and subsequent homologous desensitization of HepG2-IL-6 cells towards IL-6 . Negative_regulation IL6R IL6 17024100 1674278 Addition of peptide to NFs culture or *inhibition* of IL-6 or its receptor [IL-6R alpha] by their corresponding antibodies in KFs culture revealed a dose dependent increase or decrease in collagen type I alpha 2 and fibronectin 1 mRNAs , respectively . Negative_regulation IL6R IL6 2498129 111807 Treatment of cultured monocytes with endotoxin , interleukin-1 beta , or *results* in a decrease in [interleukin-6 receptor] mRNA levels . Negative_regulation IL6R IL6 8408066 233240 Retention of in the ER *led* to the prevention of surface expression of the IL-6 receptor protein [gp80] , making these cells unresponsive to IL-6 . Negative_regulation IL6R IL6 9820543 547568 Furthermore , preintroduction of some mutant genes delayed the erythema induced by postintroduction of the wild-type IL-6 gene , suggesting that the mutant forms of *prevent* wild-type IL-6 from binding to [IL-6Ralpha] . Negative_regulation IL6R MYLIP 24642471 2930498 p53 activation in CRC cells interfered with IL-6 induced invasion and migration via *dependent* downregulation of [IL6R] expression . Negative_regulation IL6R TIMP1 15581686 1355917 The results of the present study shows that treatment of BV reversed the LPS induced upregulation of such genes as [interleukin-6 (IL-6) receptor] , matrix metalloproteinase 15 (MMP-15) , tumor necrosis factor ( ligand ) superfamily-10 , caspase-6 and tissue *inhibitor* of metalloproteinase-1 ( ) . Negative_regulation IL6ST TP63 9614940 509533 In order to elucidate the *role* of in the [heterodimer] , chimeric HIV-1/FIV RT heterodimers were constructed and characterized . Negative_regulation IL7 IL1B 20497296 2289065 The *role* of in reduced [IL-7] production by stromal and epithelial cells : a model for impaired T-cell numbers in the gut during HIV-1 infection . Negative_regulation IL7 KLF9 14976188 1236319 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL7 TLR7 20677943 2305620 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL7 TNF 11446746 835436 We recently found that CGRP induces IL-6 and in long-term bone marrow cultures and that IL-6 and TNF-alpha also *inhibit* [IL-7] responses . Negative_regulation IL7 TNF 14962494 1182583 directly *inhibits* [IL-7] responses in B220 ( + ) /IgM ( - ) cells whereas IL-6 inhibits only colony formation with whole bone marrow . Negative_regulation IL7 TNF 8833901 386009 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL7 TNF 8957229 401632 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL7R FOXO1 19136962 2025518 Furthermore , deficiency *resulted* in a severe defect in interleukin 7 receptor alpha-chain ( [IL-7Ralpha] ) expression associated with its ability to bind an Il7r enhancer . Negative_regulation IL7R TNF 10779425 687447 The effect *resulted* in an up-regulation of [CD127] ( ie , the IL-7 receptor alpha-chain ) in a small subset of the CD34+ cells . Negative_regulation IL7R TNF 17956896 1826442 IL-7 , but not HIV gp120 , IL-1-beta , IL-6 , IL-10 , IL-13 , transforming growth factor-beta or , *reduced* [CD127-surface] expression and did so without altering CD127 mRNA expression . Negative_regulation IL8 ANGPT1 12770938 1094704 *inhibits* endothelial permeability , neutrophil adherence and [IL-8] production . Negative_regulation IL8 ANGPT1 22198097 2549646 We also observed that Ang1 , but not Ang2 can promote [IL-8] release and that a pretreatment of the neutrophils with blocking anti-IL-8 antibodies *inhibited* the anti-apoptotic effect of IL-8 and by 92 and 81 % respectively . Negative_regulation IL8 ANO1 22973054 2693546 Similarly , direct but not P2Y receptor mediated activation of *attenuates* [IL-8] secretion in respiratory epithelia . Negative_regulation IL8 ARSA 14671485 1178400 In vitro studies revealed that UR-12715 or <5-ASA> ( from 10 ( -6 ) to 10 ( -4 ) M ) *inhibited* [IL-8] production ( 30-40 % ) in HT-29 cells when incubated with LPS . Negative_regulation IL8 BPI 8409400 233339 LBP was shown to *enhance* LPS induced TNF-alpha , IL-6 , and [IL-8] release by mononuclear phagocytic cells , whereas inhibited the release of these cytokines . Negative_regulation IL8 CD14 11067940 747598 As a *result* of proteolysis , [IL-8] production by HGF was suppressed when triggered by 10 ng/ml LPS , but not by IL-1alpha , indicating that HLE inhibited a CD14 dependent cell activation . Negative_regulation IL8 CD14 12176911 975580 Thus , anti-CD14 abolished tumor necrosis factor-alpha , interleukin-6 (IL-6) , and IL-10 secretion , whereas [IL-8] was equally *inhibited* by and compstatin . Negative_regulation IL8 CD14 17156740 1678844 Our results demonstrate that release of from PMN *suppresses* secretion of [IL-8] , and may be an important regulatory mechanism for controlling excessive migration of PMN into the bovine mammary gland . Negative_regulation IL8 CD14 19047409 2023692 significantly *reduced* the levels of the E. coli induced proinflammatory cytokines TNF-alpha and IL-1beta , but not [IL-8] , in a dose dependent manner . Negative_regulation IL8 CD14 23402023 2743574 Inhibiting complement and efficiently *reduced* the expression of the E. coli induced cytokines IL-1beta , IL-6 , [IL-8] , and platelet derived growth factor bb . Negative_regulation IL8 CD14 8627030 355795 The LPS induced [IL-8] response was *blocked* by and correlated with the serum CD14 level in sepsis patients . Negative_regulation IL8 CHI3L1 15015934 1251092 *suppressed* the cytokine induced secretion of MMP1 , MMP3 and MMP13 , as well as secretion of the chemokine [IL-8] . Negative_regulation IL8 EPHB2 11978798 954061 Inhibiting , phosphatidylinositol 3-kinase , but not p38 kinase , diacylglycerol kinase , or hypoxia-inducible factor-1alpha , *attenuated* nickel induction of [IL-8] . Negative_regulation IL8 EPHB2 15731050 1377567 In contrast , inhibition of JNK and/or *resulted* in substantially less [IL-8] secretion from infected cells , independent of TLR2 or TLR5 expression . Negative_regulation IL8 EPHB2 17704189 1822344 In addition , overexpression of the MEK1 -- > ERK pathway significantly increased [IL-8] expression , and a small interfering RNA to the NADPH oxidase *inhibited* and TNF-alpha induced chemokine expression . Negative_regulation IL8 F2R 11907122 923279 , PAR-2 , or PAR-4 , in combination , caused additive IL-6 release , but only the PAR-1 and PAR-2 combination *resulted* in an additive [IL-8] response . Negative_regulation IL8 F2R 8707354 371196 These results strongly suggest that catalytic activation of by thrombin *results* in PKC dependent [IL-8] production accompanied by an increase in IL-8 mRNA level . Negative_regulation IL8 FUT4 10440571 635358 The productions of both IL-6 and [IL-8] , measured by enzyme linked immunosorbent assay , were significantly *inhibited* by at the concentration of 1 to 100 microg/ml in a dose dependent manner . Negative_regulation IL8 FUT4 10440571 635380 Furthermore , the expressions of IL-6 and [IL-8] mRNAs were also *inhibited* by . Negative_regulation IL8 FUT4 7620820 315592 [IL-8] production by PMN and vascular endothelial cells stimulated with lipopolysaccharide (LPS) was *inhibited* by . Negative_regulation IL8 HBEGF 22402363 2582154 The silencing and overexpression of HBEGF in HAECs confirmed the *role* of in regulating [IL-8] expression . Negative_regulation IL8 HBEGF 24555532 2928947 Neutralizing antibodies to AR , TGFa and *reduced* DEP induced [IL-8] by > 50 % . Negative_regulation IL8 HES2 15836676 1397670 significantly *reduced* the increased hepatic levels of TNF-alpha , IL-1beta , IL-6 , [IL-8] and the mRNAs in the endotoxemic rats . Negative_regulation IL8 HES2 16104441 1444707 significantly *reduced* the LPS induced increase in intestinal levels of TNF-alpha , IL-1beta , IL-6 , [IL-8] and their corresponding mRNAs . Negative_regulation IL8 IL1B 10490995 645869 Recombinant ( 2 ng/ml ) *induced* similar levels of [IL-8] secretion to CoMTB in both A549 cells and NHBE . Negative_regulation IL8 IL1B 10893209 711345 However , the LPS effects on TNF-alpha and [IL-8] are *inhibited* by < 20 % and the effect on by < 50 % . Negative_regulation IL8 IL1B 11048965 743163 The anti-inflammatory drug , dexamethasone ( 1 microM ) , abolished the production of both IL-6 and [IL-8] in gingival fibroblasts challenged with PHT in the *presence* or absence of . Negative_regulation IL8 IL1B 11358991 816218 The NO synthase inhibitors aminoguanidine and N ( G ) -nitro-L-arginine methyl ester blocked nuclear accumulation of activator protein-1 (AP-1) and nuclear factor (NF)-kappaB in both polymorphonuclear ( PMN ) and mononuclear leukocytes and inhibited [IL-8] mRNA expression and IL-8 release by approximately 90 % in *response* to and TNF-alpha . Negative_regulation IL8 IL1B 11446462 835392 Regulatory *role* of in the expression of IL-6 and [IL-8] in human corneal epithelial cells during Pseudomonas aeruginosa colonization . Negative_regulation IL8 IL1B 11767276 890358 We aimed to : 1 ) characterize the expression of interleukin (IL)- Ialpha and IL-Ibeta in human gingiva and cultured GEC : 2 ) demonstrate the ability of A. actinomycetemcomitans extracts to upregulate IL-1alpha , IL-1beta and IL-8 expression in GEC in vitro : and 3 ) characterize the *role* of IL-1alpha and in the induction of [IL-8] expression in GEC in vitro . Negative_regulation IL8 IL1B 12045890 895168 The *role* of in the regulation of [IL-8] and IL-6 in human corneal epithelial cells during Pseudomonas aeruginosa colonization . Negative_regulation IL8 IL1B 12672669 1099644 In postlabor amnion cells , increased IL-8 and PGE2 synthesis and COX-2 expression , but progesterone did not *attenuate* the effect of IL-1beta upon [IL-8] synthesis . Negative_regulation IL8 IL1B 16354411 1492518 Licochalcone A ( IC50 15.0 nM ) inhibited PGE2 production , but not IL-6 and [IL-8] production , in *response* to . Negative_regulation IL8 IL1B 19181383 2049300 Ablation of IRAK-4 expression in human umbilical vein endothelial cells ( HUVEC ) with siRNA suppressed IL-1beta *induced* IL-6 and [IL-8] production whereas IRAK-1 siRNA suppressed TNFalpha induced but not induced cytokine production . Negative_regulation IL8 IL1B 19513849 2098376 In the mononuclear cell and neutrophil fractions , beta-endorphin and the delta agonist DADLE increased synthesis in both the spontaneous and stimulated versions of the test , while beta-endorphin and the delta agonist DADLE *inhibited* [IL-8] production in the mononuclear cell and neutrophil fractions only in LPS stimulated cultures . Negative_regulation IL8 IL1B 20412422 2287923 Scavenger receptor inhibitors , fucoidan and dextran sulfate , inhibited the OxLDL induced [IL-8] and PGE ( 2 ) production in the *presence* of . Negative_regulation IL8 IL1B 8432783 212834 Northern blot analysis confirmed that stimulation of chorion and decidual cells *resulted* in increased [IL-8] messenger RNA expression . Negative_regulation IL8 IL1B 8506955 221475 Stimulation of HPMC with or TNF-alpha *resulted* in a time- and dose dependent [IL-8] generation ; Negative_regulation IL8 IL1B 9558101 500047 Consistent with the identification of IL-1beta as the lymphocyte factor , fibroblast or mesangial cell [IL-8] release induced by the IgG stimulated lymphocyte supernatants was *inhibited* by 1 ) the combination of IL-1R antagonist and soluble type II IL-1R , 2 ) an IL-1 converting enzyme inhibitor , or 3 ) but not preimmune Abs . Negative_regulation IL8 ITGB2 1356557 198027 The *role* of in [IL-8] induced dermal and synovial inflammation . Negative_regulation IL8 ITGB2 14613935 1187965 Co-stimulating and CD11b with activating antibodies *resulted* in NF-kappaB activation by GM-CSF and [IL-8] in suspended cells . Negative_regulation IL8 JAG1 20826750 2325237 Cyst-fluid did not elicit monocyte chemokine secretion , *inhibited* LPS induced [CXCL8] by up to 89 % , but did not alter CCL2 secretion . Negative_regulation IL8 KLF9 14976188 1236336 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL8 LBP 19010986 2029055 and sCD14 *inhibited* the nontypeable Haemophilus influenzae ( NTHi ) -dependent secretion of [IL-8] and the activation of NF-kappaB and p38 mitogen activated protein kinase signalling pathways but they increased the internalisation of NTHi by airway epithelial cells . Negative_regulation IL8 MAP2K6 18252806 1895858 Interestingly , , p38 , and IKK inhibitors *block* TNF-alpha induced [IL-8] , IL-6 , and GM-CSF secretion and 12z invasion , whereas the PI3K inhibitors do not . Negative_regulation IL8 PLAU 16410222 1494760 Importantly , atorvastatin at the micromolar concentrations diminished the production of [interleukin (IL)-8] , a proinflammatory and proangiogenic chemokine , and *inhibited* the synthesis of , a potent proinflammatory mediator . Negative_regulation IL8 RGS2 24163441 2889595 Although methacholine and U46619 induced [interleukin-8 (IL-8)] release and this was *inhibited* by overexpression , the repression of U46619 induced IL-8 release by salmeterol plus dexamethasone was unaffected by RGS2 knockdown . Negative_regulation IL8 RGS2 24163441 2889596 Given a role for Gaq mediated pathways in inducing IL-8 release , we propose that acts redundantly with other effector processes to *repress* [IL-8] expression . Negative_regulation IL8 TF 11895948 920811 Moreover , this process is specific , since serum , a glycoprotein whose structure is close to that of lactoferrin , did not *prevent* the interaction of [IL-8] with heparin . Negative_regulation IL8 TLR7 17578764 1763636 The aim of this study was to clarify the *role* of different ligands in [IL8] production in NCI-H295R cells . Negative_regulation IL8 TLR7 20067543 2177832 Here we demonstrate that tumour derived prostaglandin E2 ( PGE ( 2 ) ) and transforming growth factor-beta ( TGF-beta ) increase [interleukin-8 (IL-8)] but synergistically *inhibit* interferon-alpha (IFN-alpha) and tumour necrosis factor (TNF) production of and Toll-like receptor 9 (TLR9) stimulated PDC . Negative_regulation IL8 TLR7 20677943 2305630 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL8 TNF 10433808 634070 PGE ( 2 ) ( 1 microM or 10 nM ) reduces marrow stromal cell [IL-8] synthesis in *response* to IL-1alpha or . Negative_regulation IL8 TNF 10805216 691951 IFN-gamma as well as the GCs , Dexamethasone and Budesonide , inhibited *induced* [IL-8] secretion in a dose dependent manner . Negative_regulation IL8 TNF 12193739 981548 HMC-1 induced [IL-8] release was significantly *reduced* by the tryptase inhibitors GW-45 and GW-58 ( 90 and 87 % , respectively , at an optimal concentration ) but not by anti-stem cell factor , , or anti-IFN-gamma neutralizing Abs or by the antihistamine drugs pyrilamine and cimetidine . Negative_regulation IL8 TNF 12381718 1025310 In Madin-Darby canine kidney monolayers expressing dominant negative Rac1 or Cdc42 , both Salmonella- and alpha induced activation of NFkappaB and mitogen activated protein kinase signaling cascades proceeded normally , but [IL-8] secretion was *inhibited* . Negative_regulation IL8 TNF 12780691 1095580 In addition , we highlight the *role* of in [IL-8] secretion in MDR-TB patients . Negative_regulation IL8 TNF 12919942 1157685 activation of HEMEC *resulted* in upregulation of the cell adhesion molecules (CAM) ICAM-1 , VCAM-1 , E-selectin , and mucosal addressin CAM-1 (MAdCAM-1) , increased [IL-8] production , and enhanced leukocyte binding . Negative_regulation IL8 TNF 15034071 1223621 Elafin and murine SLPI also reduced endothelial [IL-8] release in *response* to oxidized low density lipoprotein , LPS , and and macrophage TNF-alpha production in response to LPS . Negative_regulation IL8 TNF 15225374 1264972 Strong inhibition of production and *inhibition* of [IL-8] and COX-2 mRNA expression in monocyte derived macrophages by RWJ 67657 , a p38 mitogen activated protein kinase (MAPK) inhibitor . Negative_regulation IL8 TNF 15531521 1336085 Stimulation of placenta , adipose tissue , and skeletal muscle with LPS and *resulted* in greater release of IL-6 and [IL-8] , whereas only LPS increased TNF-alpha release from all three tissues . Negative_regulation IL8 TNF 15652492 1364258 H ( 2 ) O ( 2 ) enhances TNF-alpha induced [IL-8] expression , but *inhibits* induced ET-1 expression . Negative_regulation IL8 TNF 15879558 1406182 To investigate the determinants of promoter-specific gene regulation by the glucocorticoid receptor (GR) , we compared the composition and function of regulatory complexes at two NFkappaB-responsive genes that are differentially regulated by GR. Transcription of the IL-8 and IkappaBalpha genes is stimulated by in A549 cells , but GR selectively *represses* [IL-8] mRNA synthesis by inhibiting Ser2 phosphorylation of the RNA polymerase II (pol II) C-terminal domain (CTD) . Negative_regulation IL8 TNF 16926027 1615019 Addition of exogenous Ub ( equaling day 42 concentration ) to day 0-4 plasma inhibited production by one-third of the effect detected for day 42 plasma , but also *inhibited* [IL-8] production by 40 % . Negative_regulation IL8 TNF 17207890 1724695 TNF-alpha stimulated expression of both chemokines , while the PKCalpha/beta activator 12-O-tetradecanoyl-phorbol-13-acetate ( TPA ) induced only expression of [IL-8] and *inhibited* induced RANTES expression . Negative_regulation IL8 TNF 17491020 1761567 The alpha , beta unsaturated aldehydes in cigarette smoke ( acrolein and crotonaldehyde ) inhibited production of interleukin-2 (IL-2) , IL-10 , granulocyte-macrophage colony stimulating factor , interferon-gamma , and by human T cells but did not *inhibit* production of [IL-8] . Negative_regulation IL8 TNF 17558435 1773936 CB(2) receptor mediated inhibition of cAMP production by virodhamine and CP55,940 was paralleled by inhibition of *induced* [IL-8] release . Negative_regulation IL8 TNF 17704189 1822343 In addition , overexpression of the MEK1 -- > ERK pathway significantly increased [IL-8] expression , and a small interfering RNA to the NADPH oxidase *inhibited* ERK- and induced chemokine expression . Negative_regulation IL8 TNF 18556801 1940707 In vitro , PPARgamma agonists reduced [IL-8] and MMP-9 release from airway epithelial cells in *response* to PAO1 or stimulation . Negative_regulation IL8 TNF 19046141 1999005 P4 enhanced the production of IL-1beta and [IL-8] , but *inhibited* production by monocytes stimulated with either organism . Negative_regulation IL8 TNF 19376732 2081867 Overexpression of Ref-1 *enhanced* [IL-8] gene transcription at baseline and after TNF-alpha treatment whereas Ref-1 suppression and antioxidant treatment inhibited stimulated IL-8 expression . Negative_regulation IL8 TNF 19528220 2121085 Further , adding autolyzed pneumococci to intact bacteria inhibited production of , IFN-gamma , and IL-12 in a dose dependent manner but did not *inhibit* production of IL-6 , [IL-8] , and IL-10 in response to the intact bacteria . Negative_regulation IL8 TNF 19583958 2162565 SB202190 successfully suppressed IL-6 , [IL-8] , PGE2 , and PGF2alpha secretion in macrophage exposed AF cells in *response* to . Negative_regulation IL8 TNF 20067543 2177831 Here we demonstrate that tumour derived prostaglandin E2 ( PGE ( 2 ) ) and transforming growth factor-beta ( TGF-beta ) increase [interleukin-8 (IL-8)] but synergistically *inhibit* interferon-alpha (IFN-alpha) and production of Toll-like receptor 7 (TLR7)- and Toll-like receptor 9 (TLR9) stimulated PDC . Negative_regulation IL8 TNF 20435921 2288103 TBP and dose-dependently *inhibited* TNFalpha induced secretion of interleukin (IL)-6 , [IL-8] , granulocyte macrophage-colony stimulating factor , and monocyte chemoattractant protein-1 in immortalized human endometriotic cells . Negative_regulation IL8 TNF 20827577 2325248 Basolateral stimulation with *resulted* in increased apical and basolateral [IL-8] production . Negative_regulation IL8 TNF 20827577 2325250 Apical stimulation *resulted* in increased apical , but not basolateral [IL-8] production . Negative_regulation IL8 TNF 21349589 2399581 Stimulation of endothelial monolayers with *resulted* in significant increase of toll-like receptor 4 , [interleukin-6 and -8] , and intercellular adhesion molecule-1 and vascular cellular adhesion molecule-1 gene expression in a time dependent manner . Negative_regulation IL8 TNF 22675954 2611448 The production of IL-8 was significantly increased by IL-1alpha or , and the increase of [IL-8] stimulated by IL-1alpha was *suppressed* by IL-1 ra in a dose dependent manner . Negative_regulation IL8 TNF 23918984 2830793 WSN virus infection induced expression of , IFN-ß , and [IL-8] is *inhibited* by EZH2 and its catalytic dead form ?SET . Negative_regulation IL8 TNF 24455739 2884495 Lactobacilli reduce chemokine [IL-8] production in *response* to and Salmonella challenge of Caco-2 cells . Negative_regulation IL8 TNF 7489942 335414 ( 10 mM ) significantly *suppressed* [IL-8] secretion only in the ulcerative colitis group and the change was different to those in the normal ( p = 0.007 ) and Crohn 's disease groups ( p = 0.012 ) . Negative_regulation IL8 TNF 8117936 241881 The glioma cell lines tested exhibited high levels of [IL-8] and MCAF mRNA expression upon *stimulation* with IL-1 or , while none of the neuroblastoma cell lines expressed these cytokine mRNA . Negative_regulation IL8 TNF 8172855 255426 In contrast , oxLDL did not alter LPS mediated production of [interleukin-8] and actually *inhibited* LPS induced secretion of , suggesting that some aspects of the signaling pathways for TF induction differ from those of other LPS-responsive monocyte/macrophage gene products . Negative_regulation IL8 TNF 8501341 220940 The *role* of in [interleukin (IL)-8] release in septicemia in the baboon ( 2-h infusion of live Escherichia coli , 5 x 10 ( 8 ) cfu/kg ) was investigated . Negative_regulation IL8 TNF 8506955 221474 Stimulation of HPMC with IL-1 beta or *resulted* in a time- and dose dependent [IL-8] generation ; Negative_regulation IL8 TNF 8833901 386010 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL8 TNF 8957229 401633 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation IL8 TNF 8973628 403051 During normoxia , LPS was the most potent stimulus , inducing the release of each cytokine , while fMLP showed a less pronounced effect on [IL-8] and IL-1 beta production and markedly *inhibited* production . Negative_regulation IL8 TNF 8977225 408737 The [IL-8R] on N-B cells can be *down-regulated* by IFN-gamma , IL-2 , and ( selectively on IL-8RA ) , and up-regulated by IL-4 and IL-13 , whereas IL-10 has no influence . Negative_regulation IL8 TNF 9216201 407111 N-acetylcysteine , an antioxidant , decreased the induced expression of intercellular adhesion molecule-1 on cultured epithelial cells from human bronchi ( BEAS-2A ) , and *inhibited* [IL-8] production by those cells . Negative_regulation IL8 TNF 9660302 517295 Inactivation of the NF-kappaB and 3'NF-IL-6 DNA binding sites decreased [IL-8] gene transcriptional activation in *response* to while inactivation of the 5'NF-IL-6 binding site increased IL-8 gene transcriptional activity in response to TNF . Negative_regulation IL8 TNF 9712752 527384 Our findings support a *role* for P. haemolytica LPS and in the induction of [IL-8] from bovine alveolar macrophages . Negative_regulation IL8 TNF 9719033 528274 The regulation of [IL-8] mRNA expression *induced* by recombinant human ( rHuTNF-alpha ) or rHuIL-1alpha was similar to that induced by LPS . Negative_regulation IL8 TNFSF10 16575489 1671871 To clarify the crucial role of PMN in ANCA associated vasculitis and the related mechanism , PMN was cultured with monoclonal antibody MPO-ANCA and PR3-ANCA to determine the function of phagocytosis , [Interleukin- 8 (IL-8)] production , glucose uptake , and TNF related apoptosis *induced* ligand ( ) production . Negative_regulation IL9 IL1B 10984364 732176 We also investigated the *role* of and TNF-alpha in the release of [IL-9] from human peripheral blood eosinophils . Negative_regulation IL9 KLF9 14976188 1236353 Activation and *repression* of [interleukin-12] p40 transcription by erythroid in macrophages . Negative_regulation IL9 TLR7 20677943 2305640 Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of [interleukin] 17 by naive CD4 ( + ) T cells in the *presence* of ligands . Negative_regulation IL9 TNF 10984364 732175 We also investigated the *role* of IL-1beta and in the release of [IL-9] from human peripheral blood eosinophils . Negative_regulation IL9 TNF 8833901 386011 Soluble receptor *inhibits* [interleukin] 12 production by stimulated human adult microglial cells in vitro . Negative_regulation IL9 TNF 8957229 401634 Plasma [interleukin-1] and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma ( 89.2 % ) levels . Negative_regulation ILK CTGF 19541844 2231907 Furthermore , overexpression of *increased* [integrin linked kinase] expression , activated its downstream signaling target , Akt , as well as increased mRNA expression of fibronectin . Negative_regulation ILK EPHB2 23511142 2757006 AngII increased the activity of protein kinase C-dependent phosphatase inhibitor of 17-kD ( CPI17 ) , integrin linked kinase (ILK) , and zipper interacting protein kinase (ZIPK) , The effect of AngII on CPI17 was *blocked* by and p38 MAPK inhibitor , while the effect of AngII on [ILK] and ZIPK was only blocked by ERK inhibitor . Negative_regulation ILK MAP2K6 17498677 1744492 Chemical inhibitors were used to assess the *role* of , PI3-K , and P38 MAPK signaling pathways in induction of [ILK] by CTGF . Negative_regulation INA TNF 21795525 2495174 *induced* a reversible dose- and time dependent inhibition of [I(Na)] . Negative_regulation INCENP TNF 22025632 2508082 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation INHA TNF 16946004 1639273 activates transcription of inducible repressor form of 3',5'-cyclic adenosine 5'-monophosphate-responsive element binding modulator and *represses* P450 aromatase and [inhibin alpha-subunit] expression in rat ovarian granulosa cells by a p44/42 mitogen activated protein kinase dependent mechanism . Negative_regulation INHBB IL1A 15817831 1393386 In contrast to the effect on activin A , *suppressed* [inhibin beta(B)-subunit] and , to a lesser extent , alpha-subunit mRNA expression , thereby reducing basal and FSH stimulated inhibin B secretion by the Sertoli cells . Negative_regulation INS ADRB2 14693408 1194882 Further studies of the expression of the allelic receptor in islet cells may help to resolve the *role* of in [insulin] secretion . Negative_regulation INS CA12 9733757 530983 Expression of carbonic anhydrase V in pancreatic beta cells suggests *role* for mitochondrial in [insulin] secretion . Negative_regulation INS EDN2 10842318 700024 Previously , we reported that [insulin stimulated glucose uptake (ISGU)] can be *inhibited* by ( ET-1 ) . Negative_regulation INS ENPP1 23027977 2689750 also *inhibits* [insulin] signaling , and an Enpp1 polymorphism is associated with insulin resistance . Negative_regulation INS ENPP1 23098853 2729136 Role of somatomedin-B-like domains on *inhibition* of [insulin] signaling . Negative_regulation INS EPHB2 16931794 1633025 This study provides direct evidence for a novel molecular mechanism by which oxidants can induce insulin resistance via S-glutathiolation of p21ras and *dependent* inhibition of [insulin] signaling . Negative_regulation INS FOXA1 19445897 2090614 *Role* of in mitochondrial citrate carrier gene expression and [insulin] secretion . Negative_regulation INS FOXO1 10702299 672622 The forkhead rhabdomyosarcoma transcription factor ( ) is a promising candidate to be the transcription factor that binds to the insulin response element of the insulin-like growth factor binding protein-1 ( IGFBP-1 ) promoter and *mediates* [insulin] inhibition of IGFBP-1 promoter activity . Negative_regulation INS FOXO1 18249169 1865229 A new study by Ni et al. ( 2007 ) shows that sustained activation of or FoxO3 in cardiomyocytes selectively enhances the activity of Akt/PKB and *reduces* [insulin] signaling through inhibition of calcineurin and PP2A . Negative_regulation INS FOXO1 18511845 1945195 [Insulin] or adenovirus mediated expression of constitutively active AKT1 *inhibited* and Smad3 synergy . Negative_regulation INS FOXO1 21335550 2411100 A 915-bp glucose-responsive [Ins2] promoter was *inhibited* by constitutively active , an effect unaltered by simultaneous overexpression of PDX1 . Negative_regulation INS FOXO1 21335550 2411101 We conclude that nuclear import of *contributes* to the suppression of Pdx1 and [Ins2] gene expression at low glucose , the latter via a previously unsuspected and direct physical interaction with the Ins2 promoter . Negative_regulation INS FOXO1 22298775 2570885 The Forkhead transcription factor *inhibits* through its expression in osteoblasts ß-cell proliferation , [insulin] secretion , and sensitivity . Negative_regulation INS GLP1R 22101168 2541013 To explore the *role* of the ( GLP-1R ) in geniposide regulated [insulin] secretion in rat INS-1 insulinoma cells . Negative_regulation INS GPR115 12167719 973372 [Insulin] *induces* heterologous desensitization of and insulin-like growth factor I signaling by downregulating beta-arrestin-1 . Negative_regulation INS GPR132 12167719 973361 [Insulin] *induces* heterologous desensitization of and insulin-like growth factor I signaling by downregulating beta-arrestin-1 . Negative_regulation INS GPR87 12167719 973441 [Insulin] *induces* heterologous desensitization of and insulin-like growth factor I signaling by downregulating beta-arrestin-1 . Negative_regulation INS ID1 21940780 2487658 Here , we investigated the *role* of in [insulin] secretion and glucose homeostasis . Negative_regulation INS IL1B 10076538 560584 *inhibited* glucose stimulated [insulin] release in cultured islets , but the presence of EA , EA-A , and to a lesser extent EA-S , preserved the secretory response . Negative_regulation INS IL1B 10433070 633922 We found that ( 1 ) at 10 U/ml increased nitrite production , *inhibited* [insulin] release , increased HSP-70 expression and decreased GAD-65 expression . Negative_regulation INS IL1B 10480601 643524 In particular , can *impair* glucose stimulated [insulin] production in beta-cells in vitro and can sensitize them to Fas ( CD95 ) /FasL triggered apoptosis . Negative_regulation INS IL1B 10480601 643525 We demonstrate that adenoviral gene delivery of the cDNA encoding the interleukin-1 receptor antagonist protein ( IL-1Ra ) to cultured islets results in protection of human islets in vitro against *induced* nitric oxide formation , impairment in glucose stimulated [insulin] production , and Fas triggered apoptosis activation . Negative_regulation INS IL1B 10531320 562091 By using two cell lines ( HIT-T15 and betaHC13 ) as well as Wistar rat isolated pancreatic islets , we examined the ability of two COX-2-specific antagonists , NS-398 and SC-236 , to prevent *inhibition* of [insulin] secretion . Negative_regulation INS IL1B 10531320 562092 adding back exogenous PGE ( 2 ) re-established inhibition of [insulin] secretion in the *presence* of . Negative_regulation INS IL1B 11181061 785018 Both and ( IL-1 beta + IFN-gamma ) *impaired* glucose stimulated [insulin] release and reduced the insulin content of wt islets , while ( IL-1 beta + IFN-gamma ) reduced glucose oxidation rates and cell viability . Negative_regulation INS IL1B 11181061 785019 Our data suggest that may *inhibit* glucose stimulated [insulin] release by pathways that are not NO-dependent and not related to glucose metabolism or cell death . Negative_regulation INS IL1B 11334407 809212 We also evaluated the effect of TIMP-1 on *induced* inhibition of glucose stimulated [insulin] secretion ( GSIS ) in freshly isolated rat pancreatic islets . Negative_regulation INS IL1B 12021199 943034 Lisofylline ( LSF ) , an anti-inflammatory agent , has been shown to protect pancreatic islets from *induced* inhibitory effects on [insulin] release . Negative_regulation INS IL1B 12031964 947864 Sodium salicylate also prevented from inducing EP3 and cyclooxygenase (COX)-2 gene expression in islets and thereby *prevented* IL-1beta from inhibiting glucose induced [insulin] secretion . Negative_regulation INS IL1B 12096922 961223 *induced* nitric oxide production and inhibition of [insulin] secretion in rat islets of langerhans is dependent upon the nitric oxide synthase cofactor tetrahidrobiopterin . Negative_regulation INS IL1B 12096922 961224 Using rat islets and the beta cell line BRIN-BD11 , we have investigated whether synthesis of BH ( 4 ) limits *induced* NO generation and inhibition of glucose induced [insulin] secretion . Negative_regulation INS IL1B 12096922 961225 DAHP reversed *induced* inhibition of islet [insulin] secretion , an effect prevented by sepiapterin . Negative_regulation INS IL1B 12456992 1021537 In summary , our findings stress that *induced* suppression of [insulin] secretion may be related to iNOS induction in beta cells and that RX can reverse this effect , by maintaining insulin secretion . Negative_regulation INS IL1B 12898012 1135242 Furthermore , in isolated rat pancreatic islets ONO-1714 prevented *induced* inhibition of [insulin] secretion , this protection being evident in much lower concentrations than with L-NMMA . Negative_regulation INS IL1B 1322036 192100 In contrast , basal as well as glucose- and GH-stimulated [insulin] secretion was consistently *suppressed* by from days 1-3 . Negative_regulation INS IL1B 1334975 205935 Nitric oxide has recently been implicated as the effector molecule that mediates *induced* inhibition of glucose stimulated [insulin] secretion and beta-cell specific destruction . Negative_regulation INS IL1B 1334975 205936 Pretreatment of beta-cells , purified by FACS with *results* in a 40 % inhibition of glucose stimulated [insulin] secretion that is prevented by the nitric oxide synthase inhibitor , NG-monomethyl-L-arginine ( NMMA ) . Negative_regulation INS IL1B 1384465 200510 The formation of cGMP does not appear to mediate the inhibitory effects of IL-1 beta on insulin secretion since a concentration of cycloheximide ( 1 microM ) that blocks *induced* inhibition of glucose stimulated [insulin] secretion and nitric oxide formation does not prevent cGMP accumulation , thus dissociating the two events . Negative_regulation INS IL1B 1384465 200511 These results show that IL-1 beta induced nitric oxide formation parallels the ability of to *inhibit* glucose stimulated [insulin] secretion by islets , and that protein synthesis is required for IL-1 beta induced nitric oxide formation . Negative_regulation INS IL1B 15028959 1222970 The combined inducible nitric oxide synthase inhibitor and free radical scavenger guanidinoethyldisulfide prevents multiple low-dose streptozotocin induced diabetes in vivo and *induced* suppression of islet [insulin] secretion in vitro . Negative_regulation INS IL1B 1531861 180420 Nicotinamide partially reverses the *inhibition* of glucose induced [insulin] release in pancreatic islets . Negative_regulation INS IL1B 15389634 1366721 ( ii ) Efaroxan completely inhibited *induced* suppression of [insulin] secretion and induction of iNOS mRNA transcripts , and , in addition , counteracted islet beta-cell protein profile alterations , Bax-cytochrome c translocation , caspase activation , and apoptosis ; Negative_regulation INS IL1B 15450943 1300786 Epicatechin partly restored the induced *inhibition* of [insulin] release . Negative_regulation INS IL1B 15561930 1341208 The potential role of SOCS-3 in the *induced* desensitization of [insulin] signaling in pancreatic beta-cells . Negative_regulation INS IL1B 15803864 1390825 Effects of antioxidants coenzyme Q10 and lipoic acid on mediated *inhibition* of glucose stimulated [insulin] release from cultured mouse pancreatic islets . Negative_regulation INS IL1B 15803864 1390826 In this study , the antioxidants coenzyme Q10 and lipoic acid were able to block *mediated* inhibition of glucose stimulated [insulin] secretion from islet cells at 10 ( -12 ) M and 10 ( -9 ) M , respectively . Negative_regulation INS IL1B 1655527 166237 The protease inhibitor N alpha-p-tosyl-L-lysine chloromethyl ketone , recently shown to protect completely against *induced* suppression of [insulin] production and secretion , was found to markedly reduce DNA synthesis without affecting insulin secretion . Negative_regulation INS IL1B 1657959 168969 Role of nitric oxide in *induced* inhibition of [insulin] secretion . Negative_regulation INS IL1B 1657959 168971 Evidence is presented which suggests that *induced* inhibition of [insulin] secretion is dependent on the metabolism of L-arginine to nitric oxide . Negative_regulation INS IL1B 16644698 1553154 alone *induced* a strong inhibition of [insulin] secretion and glucose oxidation rate and a marked increase in medium nitrite accumulation as an indicator of nitric oxide generation . Negative_regulation INS IL1B 1700570 143330 During beta-cell stimulation with tolbutamide , *caused* inhibition of [insulin] accumulation to 36 +/- 9 % of control . Negative_regulation INS IL1B 1731791 181383 In rat islets this probably leads to an inhibited insulin secretion , whereas in mouse islets *suppresses* [insulin] secretion by a non-mitochondrial mechanism . Negative_regulation INS IL1B 17583797 1764293 and MEKK1 specifically *inhibited* basal and membrane depolarisation and cAMP induced [INS] transcription in the beta cell line . Negative_regulation INS IL1B 17583797 1764295 Also , in primary islets of reporter gene mice , *reduced* glucose stimulated [INS] transcription . Negative_regulation INS IL1B 17583797 1764298 These data suggest that through MEKK1 *inhibits* [INS] transcription and does so , at least in part , by decreasing MafA transcriptional activity at the RIPE3b control element . Negative_regulation INS IL1B 2125218 146714 The recombinant human significantly *reduced* [insulin] secretion in ADX rats 2 and 4 hr after the injection , although IL-1 stimulated insulin secretion in intact rats . Negative_regulation INS IL1B 2137789 128805 In contrast , in the long-term , , *inhibited* both basal and secretagogue stimulated [insulin] secretion . Negative_regulation INS IL1B 2199215 138239 In contrast , after 48 h , *inhibited* [insulin] release and glucose utilisation and oxidation . Negative_regulation INS IL1B 2203826 140689 Recombinant human *inhibits* glucose induced [insulin] secretion from isolated pancreatic islets and from purified beta-cells obtained by fluorescence activated cell sorting ( FACS ) of dispersed islet cells . Negative_regulation INS IL1B 2264829 147212 However , and IL-6 were found to *inhibit* [insulin] secretion in an additive manner . Negative_regulation INS IL1B 7505613 237681 In vitro treatment of rat islets with the cytokine *results* in an inhibition of glucose stimulated [insulin] secretion that is mediated by the overproduction of nitric oxide . Negative_regulation INS IL1B 7507826 244610 The effects of several classes of agents on *induced* suppression of [insulin] secretion , beta-cell NAD levels , and beta-cell viability were examined . Negative_regulation INS IL1B 7514870 257079 Previous studies have shown that pretreatment of islets for 18 h with *results* in an inhibition of glucose stimulated [insulin] secretion that requires 4 days incubation in the absence of IL-1 beta to restore islet secretory function . Negative_regulation INS IL1B 7530059 284290 We conclude that nitric oxide produced by the inducible form of nitric oxide synthase , mediates the *induced* inhibition of [insulin] release and that the effect of IL-1 beta on temperature , pancreatic alpha-cells , and leukocyte differential counts seems to be mediated by nitric oxide produced by the constitutive form of nitric oxide synthase . Negative_regulation INS IL1B 7530759 291724 In contrast , *induces* the expression of iNOS and also inhibits [insulin] secretion by both intact islets and Facs purified beta cells , whereas TNF+LPS have no inhibitory effects on insulin secretion by purified beta cells . Negative_regulation INS IL1B 7556978 327743 *inhibition* of [insulin] release in rat pancreatic islets : possible involvement of G-proteins in the signal transduction pathway . Negative_regulation INS IL1B 7556978 327744 Cholera toxin ( 2 micrograms/ml ) or pertussis toxin ( 0.5 microgram/ml ) potentiated , as expected , glucose induced insulin release in control islets , but , in addition , when added together with IL-1 beta , were able to prevent the mediated *inhibition* of glucose stimulated [insulin] secretion ( 2087 +/- 301 and 1662 +/- 173 pg . islet-1 .h-1 , respectively , p < 0.05 vs islets exposed to IL-1 beta alone ) . Negative_regulation INS IL1B 7692996 231209 Nitric oxide has recently been implicated as a cellular molecule that mediates *induced* inhibition of glucose stimulated [insulin] secretion by islets of Langerhans . Negative_regulation INS IL1B 7692996 231210 IL-1 beta is believed to stimulate the expression of cytokine inducible nitric oxide synthase because the synthetic glucocorticoid , dexamethasone , prevents induced *inhibition* of glucose stimulated [insulin] secretion and cGMP accumulation by islets . Negative_regulation INS IL1B 7706480 297781 Since the conditioned culture media from the HITra2 cells exhibited an anti-IL-1 beta activity of only 0.5 U/ml , and mixed culture of HITra2 cells and isolated rat islets prevented *induced* inhibition of [insulin] release , it is likely that IL-1ra acts locally at the cell surface . Negative_regulation INS IL1B 8194662 258953 *mediated* inhibition of [insulin] release and damage to beta-cells are associated with intracellular production of nitric oxide ( NO ) radicals . Negative_regulation INS IL1B 8194662 258954 Therefore , we studied whether NA prevented IL-1 beta induced islet NO production , measured as nitrite release from isolated rat islets , and , if so , whether this action was associated with prevention of *mediated* inhibition of [insulin] release . Negative_regulation INS IL1B 8194662 258955 No-synthase inhibition with L-arginine depletion abolished NO production but only partially reduced *induced* inhibition of accumulated [insulin] release . Negative_regulation INS IL1B 8354339 227406 Animal experiments demonstrate that is beta-cell cytotoxic in vitro and *inhibits* [insulin] secretion in vivo . Negative_regulation INS IL1B 8405744 232434 However , at a 100-fold molar excess the interleukin-1 receptor antagonist did not antagonise the potentiating effect of interleukin-1 beta on rat islet insulin accumulation during 3 and 6 h of exposure or of induced *inhibition* of [insulin] release after 24 h . Negative_regulation INS IL1B 8440413 213318 Nitric oxide has been implicated as the effector molecule that mediates *induced* inhibition of glucose stimulated [insulin] secretion by rat islets . Negative_regulation INS IL1B 8440413 213322 The signaling process appears to require the activation of a tyrosine kinase , since the tyrosine kinase inhibitor genistein prevents both *induced* inhibition of [insulin] secretion by islets and formation of nitric oxide by the insulinoma cell line RINm5F . Negative_regulation INS IL1B 8549863 346489 Nitric oxide has been implicated as one possible mediator of *induced* inhibition of [insulin] secretion and islet cell damage . Negative_regulation INS IL1B 8808183 344464 The cytokine *caused* a significant decrease in both beta-cell mitogenesis and [insulin] accumulation , effects that were mediated through nitric oxide generation . Negative_regulation INS IL1B 8895359 392478 *caused* a 44 % decrease in islet G-stimulated [insulin] secretion compared to that in untreated islets ( P < 0.0005 ) , which was totally reversed by LSF . Negative_regulation INS IL1B 8915032 395756 This study was undertaken to investigate the influence of Linomide on IL-1beta induced diabetogenic and hormonal changes in the rat in vivo , and on *mediated* synthesis of NO and inhibition of [insulin] secretion in isolated islets of Langerhans ex vivo . Negative_regulation INS IL1B 8922366 397136 also *diminished* [insulin] secretion induced by pure mitochondrial fuels , 40 mmol/l K+ , or a phorbol ester . Negative_regulation INS IL1B 8922366 397137 In contrast , in INS-1 cells , ( 10 or 100 pmol/l ) *reduced* both basal and glucose induced [insulin] secretion by 50 % , but insulin content was also reduced by 35 % . Negative_regulation INS IL1B 8975875 403134 In vitro , the [insulin] release of encapsulated islets cultured for 2 days decreased to 32 and 28 % , respectively , in the *presence* of and macrophages . Negative_regulation INS IL1B 8987109 404117 Effects of a 33 residue interleukin-1 beta peptide and the antioxidant PQQ on *mediated* inhibition of glucose stimulated [insulin] release from cultured mouse pancreatic islets . Negative_regulation INS IL1B 8987109 404118 significantly *inhibits* [insulin] secretion from glucose stimulated islet cells . Negative_regulation INS IL1B 9245483 446668 Dexamethasone prevents *mediated* inhibition of rat islet [insulin] secretion without decreasing nitric oxide production . Negative_regulation INS IL1B 9245483 446669 We aimed to assess the effect of several steroidal hormones on *induced* inhibition of rat islet [insulin] secretion in vitro , and their possible regulatory effects on NO production . Negative_regulation INS IL1B 9245483 446671 We conclude that dexamethasone partially protects against induced *inhibition* of rat islet [insulin] secretion , an effect which is not mediated through modulation of the NO pathway . Negative_regulation INS IL1B 9374680 465297 These data ( together with the finding that *inhibited* Ca ( 2+ ) -induced [insulin] release ) suggest that , in addition to its effects on ATP synthesis and thereby on the KATP channel , IL-1 beta has at least two undescribed , distal effects to block both PLC as well as Ca ( 2+ ) -induced exocytosis . Negative_regulation INS IL1B 9375806 465363 We show that the interleukin-1 receptor antagonist protein ( IRAP ) prevents *induced* nitrite formation and IL-1beta induced inhibition of [insulin] secretion by isolated islets and primary beta-cells purified by fluorescence activated cell sorting ( FACS ) . Negative_regulation INS IL1B 9389514 467135 Treatment of rat islets for 18 h with *results* in an inhibition of glucose stimulated [insulin] secretion , mitochondrial aconitase activity , and total protein synthesis . Negative_regulation INS IL1B 9395303 468380 Insulin-like growth factor I reverses *inhibition* of [insulin] secretion , induction of nitric oxide synthase and cytokine mediated apoptosis in rat islets of Langerhans . Negative_regulation INS IL1B 9395303 468384 Here , we demonstrate that *mediated* nitric oxide formation and inhibition of [insulin] secretion are significantly reduced by 24 h pretreatment of rat islets of Langerhans with insulin-like growth factor I (IGF-I) . Negative_regulation INS IL1B 9568691 501327 *inhibits* [insulin] secretion from pancreatic beta-cells by stimulating the expression of inducible nitric oxide synthase (iNOS) that generates the free radical nitric oxide . Negative_regulation INS IL1B 9614146 509346 Inhibition of p38 but not of ERK1/2 attenuated mediated *inhibition* of glucose stimulated [insulin] release . Negative_regulation INS IL1B 9753298 533907 IL-6 ( 10 ng/ml ) also potentiated *mediated* NO synthesis and inhibition of [insulin] release , whereas beta-nerve growth factor ( NGF ) ( 5 or 50 ng/ml ) had no effect . Negative_regulation INS IL1B 9989930 597171 and TNF-alpha *inhibited* [insulin] release and glucose utilization and oxidation . Negative_regulation INS IRS4 1712770 161253 These results provide further evidence for a *role* of in [insulin] signaling . Negative_regulation INS KANK4 18458160 1909419 Furthermore , *inhibits* [insulin] and active Akt dependent activation of RhoA through binding to 14-3-3 . Negative_regulation INS MAP2K6 16931794 1633022 The requirement for oxidant mediated S-glutathiolation and activation of p21ras in mediating insulin resistance was further implicated by showing that [insulin] signaling was *restored* by inhibitors or by overexpression of glutaredoxin-1 . Negative_regulation INS MAP2K6 23217386 2707857 This study was to investigate the *roles* of ( MEK) 1 and 2 in the regulation of human insulin- and [insulin] glargine induced proliferation of human bladder cancer T24 cells . Negative_regulation INS PGC 14576981 1165152 Inhibition of islet expression by antisense oligonucleotide abrogated cold induced UCP-2 expression and partially *restored* [insulin] secretion in islets exposed to cold . Negative_regulation INS PPP1R1A 20403060 2374924 The mRNA levels of the [insulin] signalling suppressor molecule Grb10 and the glycogen synthesis *inhibitors* , and phosphorylase kinase-? , were negatively regulated by testosterone . Negative_regulation INS RARB 9260196 448716 Overexpression of *increased* [insulin] secretion at ATRA , 100-1,000 nM . Negative_regulation INS RGS2 9794454 543053 In betaTC3 cells , preincubation of GIP *attenuated* GIP induced [insulin] release by 45 % at 15 min and by 55 % at 30 min. Expression of in the betaTC3 cells significantly decreased GIP stimulated insulin secretion , whereas glucose induced insulin release was not affected . Negative_regulation INS SPHK1 22155656 2542799 To evaluate the *role* of in [insulin] secretion , we used stable transfection to knock down the expression of the Sphk1 gene in the rat insulinoma INS-1 832/13 cell line . Negative_regulation INS STK39 10092613 600615 In addition , the PDGF activated called Akt was found to *inhibit* [insulin] signaling . Negative_regulation INS TGM2 2408879 48596 *Role* of in [insulin] release . Negative_regulation INS TGM2 9211495 441358 To examine whether could *mediate* effects of retinoids on [insulin] secretion , we measured ( i ) transglutaminase activity in islets from rats deficient in vitamin A or repleted with retinol or retinoic acid , ( ii ) transglutaminase activity in RINm5F and INS-1 insulin secreting cells cultured in retinol or retinoic acid , ( iii ) mRNA for transglutaminase in RINm5F and INS-1 cells , and ( iv ) insulin secretion from INS-1 cells in response to retinoic acid . Negative_regulation INS TNF 10329978 613984 We observed that *impaired* [insulin] stimulation of IRS-1- and IRS-2 mediated PI 3-kinase activation by 54 and 55 % ( P < 0.05 ) , respectively . Negative_regulation INS TNF 10771998 478670 In vitro and interleukin 1-beta (IL-1-beta) *inhibit* [insulin] release from islet beta-cells . Negative_regulation INS TNF 11287630 800284 A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes *inhibition* of [insulin] signaling through insulin receptor substrate-1 . Negative_regulation INS TNF 11287630 800311 These results suggest that *impairs* [insulin] signaling through IRS-1 by activation of a PI 3-kinase/Akt/mTOR pathway , which is antagonized by PTEN . Negative_regulation INS TNF 11443501 833858 and leptin *inhibit* basal and glucose stimulated [insulin] secretion and gene transcription in the HIT-T15 pancreatic cells . Negative_regulation INS TNF 11454665 837712 interleukin-1beta , and interferon-gamma *inhibited* glucose stimulated [insulin] secretion from isolated rat islets of Langerhans and decreased RIN-5F cell viability . Negative_regulation INS TNF 12031982 947883 Because certain protein kinase C ( PKC ) isoforms are activated by insulin , we examined the role of PKC in *inhibition* of [insulin] signaling in primary cultures of mouse skeletal muscle . Negative_regulation INS TNF 12068289 955386 Our results indicate that adiponectin/ACRP30 deficiency and high levels in KO mice *reduced* muscle FATP-1 mRNA and IRS-1 mediated [insulin] signaling , resulting in severe diet induced insulin resistance . Negative_regulation INS TNF 15604274 1346959 Moreover , [insulin] decreased the apoptotic level *induced* by , whereas the PI3K inhibitor enhanced it . Negative_regulation INS TNF 15746249 1403258 These findings expand the mechanism by which *impairs* [insulin] signaling . Negative_regulation INS TNF 16170397 1457160 Multiple regression analysis demonstrated the important *role* of in the regulation of both the insulin resistance and in the secretion of [insulin] in women . Negative_regulation INS TNF 1649742 162904 At the latter time , significantly *suppressed* [insulin-] and insulin- plus FSH stimulated progesterone accumulation , with respective ID50 values of 0.08 +/- 0.008 and 0.06 +/- 0.014 nM , but did not affect basal progesterone accumulation or DNA content . Negative_regulation INS TNF 16754199 1571434 *impaired* [insulin] induction on GLUT4 mRNA in foetal brown adipocytes , as demonstrated by quantitative RT-PCR and Northern blot . Negative_regulation INS TNF 17158207 1694181 We hypothesized that *attenuated* [insulin] signaling by dephosphorylating Akt and its targets via ceramide activated protein phosphatase . Negative_regulation INS TNF 17373630 1713844 Role of tumor suppressor PTEN in alpha *induced* inhibition of [insulin] signaling in murine skeletal muscle C2C12 cells . Negative_regulation INS TNF 17379643 1741529 Chronic may *inhibit* [insulin] signaling effectively because it causes both IRS-1 serine phosphorylation and the following SOCS3 induction in 3T3-L1 adipocytes . Negative_regulation INS TNF 17447160 1729908 Treatment with GI rapidly induced insulin resistance whereas *impaired* [insulin] signaling in a more chronic fashion ( 48-72 h ) . Negative_regulation INS TNF 17928988 1819607 Clear evidence exists that *inhibits* [insulin] signalling and thereby glucose uptake in myocytes and adipocytes . Negative_regulation INS TNF 18296638 1878896 MKP-4 also reversed the effect of to *inhibit* [insulin] signaling ; Negative_regulation INS TNF 18372392 1906601 In summary , these data provide direct evidence that induces whole-body insulin resistance and *impairs* hepatic [insulin] signaling accompanied by overproduction of apoB100 containing VLDL particles , an effect likely mediated via TNF receptor 2 . Negative_regulation INS TNF 18443205 1938518 We determined the role of inhibitor of nuclear factor-kappaB kinase ( IKK)beta in *induced* impairments in [insulin] signaling and glucose metabolism in skeletal muscle . Negative_regulation INS TNF 19558671 2104132 *inhibited* [insulin] production but pre-treatment with oleic acid reversed this inhibitory effect . Negative_regulation INS TNF 19690174 2144411 Silencing mitogen activated protein 4 kinase 4 ( MAP4K4 ) protects beta cells from induced decrease of IRS-2 and *inhibition* of glucose stimulated [insulin] secretion . Negative_regulation INS TNF 19769745 2140948 Circulating levels , which are elevated in obesity associated insulin resistance and diabetes , *inhibit* [insulin] signalling at several points in the signalling cascade . Negative_regulation INS TNF 2104593 126834 Whereas indomethacin and NDGA did not prevent *induced* inhibition of [insulin] release , this recovered after cytokine removal from cultures protected by the cyclo/lipoxygenase inhibitors . Negative_regulation INS TNF 7530759 291718 Although induce iNOS expression and *inhibit* [insulin] secretion by intact islets , this combination does not induce the expression of iNOS by beta or alpha cells purified by fluorescence activated cell sorting ( Facs ) . Negative_regulation INS TNF 7530759 291727 Evidence suggests that *inhibit* [insulin] secretion from islets by stimulating the release of IL-1 which subsequently induces the expression of iNOS by beta cells . Negative_regulation INS TNF 7530759 291730 The IL-1 receptor antagonist protein completely prevents *induced* inhibition of [insulin] secretion and attenuates nitrite formation from islets , and neutralization of IL-1 with antisera specific for IL-1 alpha and IL-1 beta attenuates TNF+LPS induced nitrite formation by islets . Negative_regulation INS TNF 7530759 291733 Local release of IL-1 within islets appears to be required for *induced* inhibition of [insulin] secretion because TNF+LPS do not stimulate nitrite formation from islets physically separated into individual cells . Negative_regulation INS TNF 7756973 288985 Glucose induced [insulin] secretion is *inhibited* by the cytokines interleukin-1 beta (IL-1 beta) , interleukin-6 and tumour necrosis factor alpha (TNF) when combined with IL-1 beta in cultured rat islets , by IL-1 beta , and interferon gamma in mouse islets , and by combined treatment of IL-1 beta , TNF and interferon gamma in human islets . Negative_regulation INS TNF 8022753 263128 Interleukin-1 , , and interleukin-6 *inhibit* [insulin] release and may be cytotoxic to isolated pancreatic islets . Negative_regulation INS TNF 8122925 241987 Glycosylphosphatidylinositol stimulates high levels of and interleukin-1 production by macrophages and *induces* hypoglycaemia through an [insulin-mimetic] activity , and may therefore contribute to the cerebral syndrome and other malarial pathophysiology . Negative_regulation INS TNF 8543058 338812 *inhibits* glucose induced [insulin] secretion in a pancreatic beta-cell line ( INS-1 ) . Negative_regulation INS TNF 8543058 338813 The possibility that might directly *reduce* glucose stimulated [insulin] secretion in pancreatic beta-cells was examined by using an established pancreatic beta-cell line ( INS-1 ) . Negative_regulation INS TNF 8549863 346487 and interferon-gamma *inhibit* [insulin] secretion and cause DNA damage in unweaned-rat islets . Negative_regulation INS TNF 8641197 362846 The effect of TNF-alpha was more pronounced when the incubation period was extended to 6 and 12 h . also *blocked* [insulin] activation of glycogen synthase (GS) and inhibited glycogen synthesis ( measured as [ 14C ] -glucose incorporated into glycogen ) . Negative_regulation INS TNF 8662983 367844 *inhibits* [insulin] signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase . Negative_regulation INS TNF 8662983 367846 These data strongly suggest that *inhibits* [insulin] signaling via stimulation of p55 TNFR and sphingomyelinase activity , which results in the production of an inhibitory form of IRS-1 . Negative_regulation INS TNF 8783331 380496 Cryopreservation did not significantly modify the hormone response to glucose but it partially reversed the *induced* inhibitory effect on [insulin] release in the presence of 20 mM glucose . Negative_regulation INS TNF 9013754 405346 and leptin , which are overproduced in fat tissue of obese insulin resistant animal models and in obese humans , might *mediate* such an inhibitory effect on [insulin] signalling in skeletal muscle . Negative_regulation INS TNF 9312188 455486 Thiazolidinediones block *induced* inhibition of [insulin] signaling . Negative_regulation INS TNF 9568681 501318 acutely *inhibits* [insulin] signaling in human adipocytes : implication of the p80 tumor necrosis factor receptor . Negative_regulation INS TNF 9691088 523114 Inhibition of iNOS activity by aminoguanidine also attenuates + LPS + IFN-gamma induced *inhibition* of [insulin] secretion by human islets . Negative_regulation INS TNF 9704567 525573 Moreover , significantly *attenuated* [insulin-] and LH-induced androstenedione production by thecal cells from large follicles . Negative_regulation INS TNF 9704567 525574 Thus , it appears that *inhibits* [insulin-] and IGF-I induced estradiol production by granulosa cells and androstenedione production by thecal cells via TNF-alpha binding to its own receptor . Negative_regulation INS TNF 9989930 597170 IL-1beta and *inhibited* [insulin] release and glucose utilization and oxidation . Negative_regulation INSM1 CCND1 16569215 1568416 Overexpression of and HDAC-3 significantly *enhanced* the transcriptional repression activity of [INSM1] on the neuroD/beta2 promoter . Negative_regulation INSR ENPP1 16527214 1536140 The genetic investigation of early-onset form of familial obesity linkage to chromosome 6q led to the identification of , an *inhibitor* of the [insulin receptor] , as a possible molecular mechanism behind both obesity and type 2 diabetes . Negative_regulation INSR ENPP1 23762820 2798229 These proteins interfere with different steps in insulin signaling : and the phosphatases PTP1B and PTPRF/LAR *inhibit* the [insulin receptor] activation ; Negative_regulation INSR TNF 10707555 673442 For example , from adipocytes *reduces* tyrosine kinase activity of the [insulin receptor] in obesity . Negative_regulation INSR TNF 11887456 894217 In addition , , a potent *inhibitor* of the tyrosine kinase activity of the [insulin receptor] , has been implicated as an etiologic factor for insulin resistance . Negative_regulation INSR TNF 15358232 1293405 is linked with insulin resistance , as greater amounts of TNF are detected in muscle and adipose tissue in glycemically challenged people and TNF-alpha *inhibits* [insulin receptor] signalling . Negative_regulation INSR TNF 20009360 2232263 In contrast , reduced the ability of IGF-I to stimulate phosphorylation of HR with reducing amounts of HR. Exposure to TNF-alpha also *attenuated* phosphorylation of [insulin receptor substrate-1 (IRS-1)] and the association of IRS-1 with phosphatydilinositol-3 kinase ( PI-3 kinase ) . Negative_regulation INSR TNF 20208423 2265455 The *induced* suppression of the tyrosine phosphorylation of the [insulin receptor substrate-1 (IRS-1)] and Akt in 3T3-L1 adipocytes was also reversed by SAM . Negative_regulation INSR TNF 8253716 238298 *suppresses* insulin induced tyrosine phosphorylation of [insulin receptor] and its substrates . Negative_regulation INSR TNF 8617880 353906 The aim of the present study was to characterize the mechanism of TNF-alpha induced insulin receptor inhibition and to compare the consequences of and hyperglycemia induced [insulin receptor] *inhibition* for signal transduction downstream from the IR . Negative_regulation INTS2 TNF 21850315 2490725 Our data suggest that reduced estrogen levels and enhanced activity *delayed* WH [in T2D] by attenuating TGFß/Smad signaling and impairing the resolution of inflammation ; Negative_regulation IQGAP1 SPHK1 21304987 2388596 Silencing of by siRNA *attenuated* Rac1 and [IQGAP1] translocation to the cell periphery ; Negative_regulation IRAK4 IL1B 9658753 517164 Conversely , neutralization of endogenous IL-10 was found to augment both tumor necrosis factor-alpha and production and *inhibit* [IL-1 receptor] antagonist production . Negative_regulation IRAK4 TNF 7931065 275191 [IL-1 receptor] desensitization is not *initiated* by , which also stimulates NF-kappa B translocation , and is not a consequence of alterations in either IL-1 receptor expression or binding affinity . Negative_regulation IRAK4 TNF 9658753 517163 Conversely , neutralization of endogenous IL-10 was found to augment both and IL-1 beta production and *inhibit* [IL-1 receptor] antagonist production . Negative_regulation IRF1 TNF 14708625 1181176 Both and interferon-gamma induced interferon regulatory factor-1 gene transcription , as assessed by the measurement of unspliced , nascent , heterogeneous nuclear RNA , and treatment with iron chelators *blocked* tumor necrosis factor-alpha or interferon-gamma mediated [interferon regulatory factor-1] gene transcription . Negative_regulation IRF1 TNF 15671209 1366095 Phloretin did not affect stimulated activation of nuclear factor kappaB (NF-kappaB) but *inhibited* activation of [interferon regulatory factor 1] , a transcription factor involved in the regulation of endothelial cell adhesion molecule expression . Negative_regulation IRF3 CD14 22901688 2775127 Given that the ability of LPS to activate [IRF3] downstream of TLR4 depends on internalisation of the TLR4 complex and *involves* , we examined TLR4 endocytosis . Negative_regulation IRF7 TLR7 23389942 2787025 Mechanisms of type I IFN inhibition did not involve downregulation but the *inhibition* of [IRF-7] expression and nuclear translocation in pDC after their exposure to tumor derived supernatants or recombinant TGF-ß1 and TNF-a . Negative_regulation IRS1 EPHB2 16805793 1579625 The increase in [IRS-1/IRS-2] levels induced by nicotine was *prevented* by nicotinic acetylcholine receptor ( nAChR ) antagonists , the Ca ( 2+ ) chelator 1,2-bis ( 2-aminophenoxy ) -ethane-N , N,N ' , N'-tetra-acetic acid tetrakis-acetoxymethyl ester , cycloheximide or actinomycin D. Nicotine increased IRS-1 and IRS-2 mRNA levels by approximately 57 and approximately 50 % , and this was prevented by conventional protein kinase C ( cPKC ) inhibitor Gö6976 , or kinase inhibitors PD98059 and U0126 . Negative_regulation IRS1 EPHB2 19762915 2158786 In normal human chondrocytes , tBHP triggered strong IRS-1 ( Ser-312 and Ser-616 ) and phosphorylation and *inhibited* IGF-I induced [IRS-1] ( Tyr-612 ) and Akt phosphorylation . Negative_regulation IRS1 FOXO1 22326951 2560647 Furthermore , we found that *dependent* downregulation of [IRS1] resulted in blunted Akt signaling and insulin resistance . Negative_regulation IRS1 IL1B 17038556 1674599 These results demonstrate that *reduces* [IRS-1] expression at a transcriptional level through a mechanism that is ERK dependent and at a posttranscriptional level independently of ERK activation . Negative_regulation IRS1 MAP2K6 12554784 1057068 The mutant , which activates p38 , moderately *inhibited* [IRS-1] and IRS-2 expressions and IRS-1 associated PI3K activity without exerting a significant effect on the IR . Negative_regulation IRS1 MAP2K6 21119656 2372358 Importantly , inhibition of and mTOR *resulted* in increased levels of pAKT and [IRS-1] , and a-TEA blocked them . Negative_regulation IRS1 TNF 10329978 613985 We observed that *impaired* insulin stimulation of [IRS-1-] and IRS-2 mediated PI 3-kinase activation by 54 and 55 % ( P < 0.05 ) , respectively . Negative_regulation IRS1 TNF 11043572 742366 We observe that *requires* 2.5-4 h to markedly reduce insulin triggered tyrosine phosphorylation of [IRS-1] in 3T3-L1 adipocytes . Negative_regulation IRS1 TNF 11287630 800285 *inhibited* insulin promoted tyrosine phosphorylation of [IRS-1] and activated the Akt/protein kinase B serine-threonine kinase , a downstream target for phosphatidylinositol 3-kinase ( PI 3-kinase ) . Negative_regulation IRS1 TNF 11287630 800303 Conversely , *inhibition* of [IRS-1] tyrosine phosphorylation was blocked by kinase dead Akt . Negative_regulation IRS1 TNF 11410238 826401 Overall , the present study demonstrates that VO ( opt ) ( 2 ) exerts an anti-diabetic effect in ob/ob mice by ameliorating impaired glucose tolerance , and furthermore , attenuates the *induced* decrease in [IRS-1] phosphorylation in adipocytes . Negative_regulation IRS1 TNF 11563846 863012 had no effect on insulin induced tyrosine-phosphorylation of IR or IRS-1 , but *inhibited* insulin stimulated [IRS-1/PI3K-association] by 84 % . Negative_regulation IRS1 TNF 11707432 903900 Pharmacological depletion of GM3 in adipocytes by an inhibitor of glucosylceramide synthase prevented the *induced* defect in insulin dependent tyrosine phosphorylation of [IRS-1] and also counteracted the TNF-alpha induced serine phosphorylation of IRS-1 . Negative_regulation IRS1 TNF 12887130 1116899 significantly ( p < 0.05 ) *inhibited* [IRS-1] phosphorylation by insulin but had no effect on ERK in L6 . Negative_regulation IRS1 TNF 16505233 1529388 Moreover , SOCS3 is required for full *inhibition* of insulin stimulated [IRS-1] and -2 phosphorylation , phosphatidylinositol 3 kinase activity , and glucose uptake . Negative_regulation IRS1 TNF 17327424 1706597 To define whether these observations were direct effects of the nutrient intervention , complimentary cell culture studies showed that c9,t11-CLA inhibited *induced* downregulation of [insulin receptor substrate 1] and GLUT4 mRNA expression and promoted insulin stimulated glucose transport in 3T3-L1 adipocytes compared with linoleic acid . Negative_regulation IRS1 TNF 18952604 2001050 RNAi knockdown demonstrated an important role for S6K1 in mediating *induced* [IRS-1] inhibition that led to impaired insulin stimulated glucose uptake in adipocytes . Negative_regulation IRS1 TNF 19782747 2183817 We found that a reduction in PKCdelta protein levels reversed the *mediated* reduction in insulin stimulated [IRS-1] Tyr phosphorylation , Akt activation , and glycogen synthesis . Negative_regulation IRS1 TNF 20009360 2232264 In contrast , reduced the ability of IGF-I to stimulate phosphorylation of HR with reducing amounts of HR. Exposure to TNF-alpha also *attenuated* phosphorylation of insulin receptor substrate-1 (IRS-1) and the association of [IRS-1] with phosphatydilinositol-3 kinase ( PI-3 kinase ) . Negative_regulation IRS1 TNF 20181658 2259183 Anti-TNF-alpha neutralization antibody and silencing of *diminished* the TCDD induced downregulation of IRbeta , [IRS1] , and GLUT4 . Negative_regulation IRS1 TNF 20181658 2259185 Taken together , TCDD stimulates expression and secretion of TNF-alpha in adipocytes through activation of AhR , ERK1/2 , and JNK , and the secreted *causes* the downregulation of IRbeta , [IRS1] , and GLUT4 through TNFR1 , resulting in insulin resistance . Negative_regulation IRS2 EPHB2 16805793 1579626 The increase in [IRS-1/IRS-2] levels induced by nicotine was prevented by nicotinic acetylcholine receptor ( nAChR ) antagonists , the Ca ( 2+ ) chelator 1,2-bis ( 2-aminophenoxy ) -ethane-N , N,N ' , N'-tetra-acetic acid tetrakis-acetoxymethyl ester , cycloheximide or actinomycin D. Nicotine increased IRS-1 and IRS-2 mRNA levels by approximately 57 and approximately 50 % , and this was *prevented* by conventional protein kinase C ( cPKC ) inhibitor Gö6976 , or kinase inhibitors PD98059 and U0126 . Negative_regulation IRS2 FOXO1 20501674 2294831 We show that hepatic production *resulted* in significant induction of IR and [IRS2] expression . Negative_regulation IRS2 MAP2K6 12554784 1057069 The mutant , which activates p38 , moderately *inhibited* IRS-1 and [IRS-2] expressions and IRS-1 associated PI3K activity without exerting a significant effect on the IR . Negative_regulation IRS2 TNF 10202031 605920 also *blocked* IL-4 induced tyrosine phosphorylation of [IRS-2] , but not of STAT6 . Negative_regulation IRS2 TNF 16505233 1529390 Moreover , SOCS3 is required for full *inhibition* of insulin stimulated [IRS-1 and -2] phosphorylation , phosphatidylinositol 3 kinase activity , and glucose uptake . Negative_regulation IRS2 TNF 16712794 1564778 On the other hand , addition of or IL-6 neutralizing antibodies to the supernatant of co-culture *recovered* both [IRS-2] phosphorylation and Akt activation . Negative_regulation IRS2 TNF 19690174 2144412 Silencing mitogen activated protein 4 kinase 4 ( MAP4K4 ) protects beta cells from *induced* decrease of [IRS-2] and inhibition of glucose stimulated insulin secretion . Negative_regulation IRS4 IL4 7492780 332452 IL-13 and stimulation of murine L cell fibroblasts , which endogenously express the IL-4 receptor ( IL-4R alpha ) and lack expression of the IL-2 receptor gamma subunit ( IL-2R gamma ) , *resulted* in tyrosine phosphorylation of [insulin receptor substrate-1 (IRS-1)/4PS] . Negative_regulation IRS4 IL9 11788580 916889 Overexpression of IRS-1 and IRS-2 , but not [IRS-4] , induced proliferation of 32D ( IR ) cells in *response* to . Negative_regulation ITGA2 MAP2K6 11287413 819813 In contrast , expression of ERK phosphatase or dominant negative *inhibited* HGF induced [integrin alpha(2)] expression . Negative_regulation ITGA2B ARSA 12297125 991225 plus cocoa *inhibited* ADP stimulated [GPIIb/IIIa-act] expression at 6 h . Negative_regulation ITGA2B ARSA 18413191 2010289 In vitro , significantly *inhibited* both [GPIIb-IIIa] expression ( 36.5 % ) and P-selectin expression ( 81 % ; Negative_regulation ITGA2B HES2 16987338 1617838 HES200/0.5 and *reduced* the CD42b , [CD41/61] and CD62p expression of ADP-agonist activated platelets at 15 min after intravenous infusion . Negative_regulation ITGA4 PLAU 10540331 563374 *inhibits* [alpha 4 beta 1 integrin] mediated T lymphocyte adhesion to fibronectin independently of its catalytic activity . Negative_regulation ITGA4 SELL 10037043 591999 in vitro incubation with SCF or IL-3 *enhanced* the expression of [CD49d] on CD34+ cells , while GM-CSF reduced the expression of . Negative_regulation ITGA5 CD14 7902377 234570 Like IL-4 , it *enhanced* the expression of CD11b , CD11c , CD18 , CD29 , [CD49e] ( VLA-5 ) , class II MHC , CD13 , and CD23 , whereas it decreased the expression of CD64 , CD32 , CD16 , and in a dose dependent manner . Negative_regulation ITGA5 ITGB2 1354234 192661 Activation of PMN with phorbol ester or C5a stimulated [VLA-5] mediated adhesion to fibronectin , but the contribution of VLA-5 to the forces mediating adherence could only be *detected* when function was either blocked with mAb , or when CD18 was congenitally absent . Negative_regulation ITGAL APOB 9863542 556106 In addition , *inhibited* IL-1 and TNF production and the expression of [CD11a] , CD11b , CD11c and CD14 by the mononuclear cells of FH patients and this may be an additional beneficial effect of LDL-apheresis apart of decreasing LDL concentrations . Negative_regulation ITGAL CA2 10195438 603945 A binding cyclic peptide *derived* from the alpha-subunit of LFA-1 : inhibitor of [ICAM-1/LFA-1] mediated T-cell adhesion . Negative_regulation ITGAL CD209 15752559 1379954 Surprisingly , initial binding of gp120 to did not *result* in increased adhesion levels of [LFA-1] to its ligand ICAM-1 in both immature DC and Raji-DC-SIGN cells . Negative_regulation ITGAL CD4 9241107 445953 This hypothesis is supported by our findings of soluble recombinant *inhibition* of HIV induced [CD11a] upregulation . Negative_regulation ITGAL CDKN2A 9865919 556413 These include myc proto-oncogene , 40S ribosomal protein S19 , heat shock proteins , leukosialin S ( CD43 ) , [integrin alphaL] ( CD11A ) , calgranulin (A) , and CDK4 *inhibitor* ( ) . Negative_regulation ITGAL ICAM1 20190141 2229246 Others have demonstrated that the targeted disruption of [LFA-1] : interactions , either by gene deletion or Ab treatment in mice , *results* in reduced leukocyte trafficking , inflammatory responses , and inhibition of inflammatory arthritis in the K/BxN serum transfer model . Negative_regulation ITGAL ICAM2 20190141 2229247 Others have demonstrated that the targeted disruption of [LFA-1] : interactions , either by gene deletion or Ab treatment in mice , *results* in reduced leukocyte trafficking , inflammatory responses , and inhibition of inflammatory arthritis in the K/BxN serum transfer model . Negative_regulation ITGAL ICAM3 20190141 2229248 Others have demonstrated that the targeted disruption of [LFA-1] : interactions , either by gene deletion or Ab treatment in mice , *results* in reduced leukocyte trafficking , inflammatory responses , and inhibition of inflammatory arthritis in the K/BxN serum transfer model . Negative_regulation ITGAL ICAM4 20190141 2229249 Others have demonstrated that the targeted disruption of [LFA-1] : interactions , either by gene deletion or Ab treatment in mice , *results* in reduced leukocyte trafficking , inflammatory responses , and inhibition of inflammatory arthritis in the K/BxN serum transfer model . Negative_regulation ITGAL ICAM5 20190141 2229250 Others have demonstrated that the targeted disruption of [LFA-1] : interactions , either by gene deletion or Ab treatment in mice , *results* in reduced leukocyte trafficking , inflammatory responses , and inhibition of inflammatory arthritis in the K/BxN serum transfer model . Negative_regulation ITGAL IL7 9420139 472423 A new *role* for in the induction of [LFA-1] and VLA-4 adhesion molecules in Phorbol 12myristate 13acetate activated CD4+ CD23+ T-cell subset . Negative_regulation ITGAL ITGA4 17828290 1817737 Corroboration that disrupting the [ICAM/LFA1] interaction or the interaction *blocked* MNP-epithelial cell interaction and injury was obtained in vitro using both blocking monoclonal antibodies and the small molecule integrin antagonists , BIO5192 and XVA143 . Negative_regulation ITGAL ITGAM 8707129 376341 The basal expression of L-selectin , [CD11a] , and CD15 was significantly decreased in jaundiced patients ( p < 0.05 ) and the expression of in response to stimulation with fMLP and endotoxin was significantly *impaired* in the jaundiced group . Negative_regulation ITGAL ITGB1 17828290 1817738 Corroboration that disrupting the [ICAM/LFA1] interaction or the interaction *blocked* MNP-epithelial cell interaction and injury was obtained in vitro using both blocking monoclonal antibodies and the small molecule integrin antagonists , BIO5192 and XVA143 . Negative_regulation ITGAL ITGB2 1684295 173150 Cell-surface expression of human *had* no apparent effect on the level of endogenous murine [CD11a/CD18] expression . Negative_regulation ITGAL ITGB2 1976304 141698 Retroviral mediated gene transfer of into LAD EBV B-cells *resulted* in low , but readily measurable , levels of surface expression of the [CD11a/CD18] complex in these previously deficient lymphocytes . Negative_regulation ITGAL ITIH4 15752559 1379955 Surprisingly , initial binding of to DC-SIGN did not *result* in increased adhesion levels of [LFA-1] to its ligand ICAM-1 in both immature DC and Raji-DC-SIGN cells . Negative_regulation ITGAL MYC 11009078 735859 *inhibited* [CD11a] and CD11c integrin promoter activity in co-transfection experiments , and similar repression was obtained in cells where c-Myc expression ( KmycB ) or activity ( Rat-1 c-MycER ) is inducible . Negative_regulation ITGAL NA 12163056 972306 markedly *down-regulated* [CD11a/LFA-1alpha] expression in a dose dependent manner . Negative_regulation ITGAL NA 12163056 972309 Furthermore , also *down-regulated* [CD11a/LFA-1alpha] expression in both U937 cells and peripheral blood monocytes . Negative_regulation ITGAL NR3C2 11834839 911154 These LFA-1 antagonists bound [LFA-1] , blocked binding of ICAM-1 , and *inhibited* a with potency significantly greater than that of cyclosporine A . Negative_regulation ITGAL ODC1 23418509 2744104 Inhibition of , which is required for polyamine synthesis , in Jurkat cells by 3 mM D , L-alpha-difluoromethylornithine hydrochloride ( DFMO ) significantly decreased spermine and spermidine concentrations and was associated with decreased DNA methyltransferase (Dnmt) activity , enhanced demethylation of the LFA-1 gene ( ITGAL ) promoter area , and *increased* [CD11a] expression . Negative_regulation ITGAL PIK3C3 9341793 458795 Down-regulation of [LFA-1] mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 *requires* activity . Negative_regulation ITGAL PIK3R4 9341793 458796 Down-regulation of [LFA-1] mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 *requires* activity . Negative_regulation ITGAL PXN 22274710 2520564 Central *role* of phosphorylation in regulation of [LFA-1] integrins activity and lymphocyte migration . Negative_regulation ITGAL RUNX1 12855590 1149928 The relevance of the AML-110 element is underscored by the ability of to *inhibit* [CD11a] promoter activity , thus explaining the low CD11a/CD18 expression in t ( 8 ; 21 ) -containing myeloid leukemia cells . Negative_regulation ITGAL TGM4 22659657 2610849 can *repress* [CD11a] gene expression through enhancing DNA methylation of ITGAL promoter in CD4 ( + ) T cells from patients with SLE . Negative_regulation ITGAL VCAM1 10438720 634987 Preincubation of interleukin-4 (IL-4) stimulated human umbilical vein endothelial cells ( HUVECs ) with anti-CD31 monoclonal antibodies ( MoAbs ) enhanced eosinophil adhesion to the IL-4 stimulated HUVECs , and the endothelial CD31 induced enhancement of eosinophil adhesion to IL-4 stimulated HUVECs was *prevented* by ( VCAM-1 ) MoAb and anti-very late activation antigen-4 (VLA-4) MoAb , but not by anti-intercellular adhesion molecule-1 ( ICAM-1 ) MoAb , anti-lymphocyte function associated antigen-1 ( [LFA-1] ) MoAb , anti-P-selectin MoAb , or anti-E-selectin MoAb . Negative_regulation ITGAM CD14 17389579 1741662 The relative role of complement and in Escherichia coli *induced* leukocyte [CD11b] up-regulation , phagocytosis , and oxidative burst in human whole blood was examined . Negative_regulation ITGAM IL1B 9142862 428545 During reoxygenation , both whole blood PMN phagocytosis and bactericidal activity were reduced in the presence of IL-8 , TNF-alpha , or , and in subsets of PMN with reduced phagocytosis H/R *reduced* CD64 , CD32w , CD16 , CD35 , and [CD11b/CD18] expression in the presence of each cytokine . Negative_regulation ITGAM SELL 10529602 561977 In contrast , the expression of [CD11b] was significantly *enhanced* after 24 h of incubation with anti-CD53 mAb , while the expression of was significantly reduced with anti-CD81 mAb . Negative_regulation ITGAM SELL 16415171 1527609 The binding of platelets to monocytes via P-selectin-PSGL-1 interactions was shown to *increase* expression and activity of alpha4beta1 and [alphaMbeta2integrin] , with a concomitant decrease in expression . Negative_regulation ITGAM SELL 8609224 352767 In the absence of serum , galactoxylomannan and mannoprotein did not affect L-selectin , TNF receptor , CD15 , [CD11b] , or CD16 on neutrophils but did *induce* loss of in the presence of serum . Negative_regulation ITGAM SELL 9689553 522937 Granulocyte-colony stimulating factor *induced* [Mac-1] expression in a dose dependent manner , whereas expression was unaffected or reduced at high concentrations . Negative_regulation ITGAM TNF 9142862 428544 During reoxygenation , both whole blood PMN phagocytosis and bactericidal activity were reduced in the *presence* of IL-8 , , or IL-1beta , and in subsets of PMN with reduced phagocytosis H/R reduced CD64 , CD32w , CD16 , CD35 , and [CD11b/CD18] expression in the presence of each cytokine . Negative_regulation ITGAV PECAM1 10438720 634988 stimulation of HUVECs increased the adhesive function of alphavbeta3 integrin to its ligand RGD peptide , the binding of which reached a maximum at 10 minutes after the stimulation , and the CD31 induced [alphavbeta3 integrin] activation on HUVECs was *inhibited* by inhibitors of protein kinase C and phosphatidylinositol 3 kinase ( PI3-kinase ) . Negative_regulation ITGAX CD14 7902377 234573 Like IL-4 , it *enhanced* the expression of CD11b , [CD11c] , CD18 , CD29 , CD49e ( VLA-5 ) , class II MHC , CD13 , and CD23 , whereas it decreased the expression of CD64 , CD32 , CD16 , and in a dose dependent manner . Negative_regulation ITGB1 CD14 7902377 234576 Like IL-4 , it *enhanced* the expression of CD11b , CD11c , CD18 , [CD29] , CD49e ( VLA-5 ) , class II MHC , CD13 , and CD23 , whereas it decreased the expression of CD64 , CD32 , CD16 , and in a dose dependent manner . Negative_regulation ITGB1 PLAU 10540331 563375 *inhibits* [alpha 4 beta 1 integrin] mediated T lymphocyte adhesion to fibronectin independently of its catalytic activity . Negative_regulation ITGB2 ACTN1 19750481 2175901 Cathepsin X cleaves the beta2 cytoplasmic tail of [LFA-1] *inducing* the intermediate affinity form of LFA-1 and binding . Negative_regulation ITGB2 ALB 7515857 257298 The up-regulation of [Mac-1] was equally *reduced* by on monocytes and neutrophils . Negative_regulation ITGB2 ALPPL2 16817789 1581035 [Mac-1] ( CD11b/CD18 ) expression on the peripheral neutrophils , increased compared with normal subjects , was *reduced* by . Negative_regulation ITGB2 APOB 9068082 419006 In addition , the A23187 stimulated increase in PMN adherence to fibrinogen coated surfaces , mediated by [CD11b/CD18] , was virtually eliminated in the presence of rHDL and HDL , but not in the *presence* of apolipoprotein A-I or natural low density . Negative_regulation ITGB2 CALML3 19806052 2159652 Instead , *induced* plasma levels of MIP-2 were significantly reduced in CD40L-deficient mice and inhibition of the MIP-2 receptor ( CXCR2 ) decreased [Mac-1] expression on neutrophils in septic animals . Negative_regulation ITGB2 CBL 18239087 1884597 Consistently , [LFA-1] mediated adhesion of BMDM to ICAM-1 but not VLA-4 mediated adhesion to VCAM-1 was *enhanced* by deficiency . Negative_regulation ITGB2 CBL 18239087 1884598 In conclusion , deficiency *activates* [LFA-1] and LFA-1 mediated inflammatory cell recruitment by stimulating the interaction between the LFA-1 beta-chain and 14-3-3 proteins . Negative_regulation ITGB2 CD4 15259014 1272568 By using specific inhibitors , raft integrity and CD4 association with GM3 were found necessary for observing the *dependent* inhibition of [LFA-1] mediated adhesion . Negative_regulation ITGB2 CD4 8943387 400012 Phosphatidylinositol 3-kinase participates in p56 ( lck ) *dependent* down-regulation of [LFA-1] mediated T cell adhesion . Negative_regulation ITGB2 CD4 8943387 400017 These results strongly suggest that induced PI3-kinase activation , in the absence of concomitant TCR/CD3 triggering , *leads* to down-regulation of [LFA-1] mediated T cell adhesion to B cells . Negative_regulation ITGB2 CD4 9531311 496842 The , but not CD4/11a , chimera profoundly *inhibited* [LFA-1] mediated cell adhesion to ICAM-1 , as well as cell spreading following cell adhesion . Negative_regulation ITGB2 CRK 20421794 2256497 This decrease in MAPK activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Negative_regulation ITGB2 CSF2 10881945 709237 In addition , MoAb , but not anti-VEGF or anti-IL-8 MoAb , *reduced* PMN CD11b and [CD18] overexpression induced by tumour conditioned medium ( p < 0.05 ) . Negative_regulation ITGB2 CYTH1 10835351 697834 In contrast , [LFA-1] mediated cell adhesion and spreading on intercellular cell adhesion molecule 1 is strongly *inhibited* by a mutant , which fails to catalyze ARF GDP-GTP exchange in vitro . Negative_regulation ITGB2 EDNRA 10229544 611045 Flow cytometric analysis showed that markedly *reduced* the expression of CD14 and [CD11c/CD18] on the surface of AMs . Negative_regulation ITGB2 EEF1A2 19424968 2090184 This inhibition was paralleled by a *dependent* inhibition of [LFA-1] mediated adhesion and a reduction of NK-cell polarization . Negative_regulation ITGB2 FN1 1619918 191450 In the *presence* of or laminin , LPS reduced [CD11b/CD18] expression ( the fibronectin receptor ) as assessed using sheep erythrocytes coated with C3bi . Negative_regulation ITGB2 FUT1 15855822 1404115 or FOY significantly *reduced* protease induced expression of [MAC-1] and ICAM-1 . Negative_regulation ITGB2 FUT10 15855822 1404114 or FOY significantly *reduced* protease induced expression of [MAC-1] and ICAM-1 . Negative_regulation ITGB2 FUT11 15855822 1404113 or FOY significantly *reduced* protease induced expression of [MAC-1] and ICAM-1 . Negative_regulation ITGB2 FUT2 15855822 1404116 or FOY significantly *reduced* protease induced expression of [MAC-1] and ICAM-1 . Negative_regulation ITGB2 FUT3 15855822 1404117 or FOY significantly *reduced* protease induced expression of [MAC-1] and ICAM-1 . Negative_regulation ITGB2 FUT4 15855822 1404118 or FOY significantly *reduced* protease induced expression of [MAC-1] and ICAM-1 . Negative_regulation ITGB2 FUT5 15855822 1404119 or FOY significantly *reduced* protease induced expression of [MAC-1] and ICAM-1 . Negative_regulation ITGB2 FUT6 15855822 1404120 or FOY significantly *reduced* protease induced expression of [MAC-1] and ICAM-1 . Negative_regulation ITGB2 FUT7 15855822 1404121 or FOY significantly *reduced* protease induced expression of [MAC-1] and ICAM-1 . Negative_regulation ITGB2 FUT8 15855822 1404122 or FOY significantly *reduced* protease induced expression of [MAC-1] and ICAM-1 . Negative_regulation ITGB2 FUT9 15855822 1404123 or FOY significantly *reduced* protease induced expression of [MAC-1] and ICAM-1 . Negative_regulation ITGB2 GTF2H5 9882713 584386 ( 0.1-10 microM ) significantly *inhibited* [Mac-1] up-regulation and neutrophil adhesion , as induced by N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) or phorbol-myristate-acetate ( PMA ) . Negative_regulation ITGB2 GTF2H5 9882713 584388 In contrast , as well as two Ca++ channel antagonists , verapamil and nifedipine , markedly *diminished* fMLP- and PMA induced Ca++ influx , [Mac-1] up-regulation , and adhesion . Negative_regulation ITGB2 HLA-DRA 11899433 894250 The results show that exposure to LPG did not affect the expression of major histocompatibility complex ( and B7 , but *induced* an up-regulation of CD25 , CD31 and vascular endothelial (VE)-cadherin expression and a down-regulation of [Mac-1] expression , by LC . Negative_regulation ITGB2 HLA-DRB1 11899433 894251 The results show that exposure to LPG did not affect the expression of major histocompatibility complex ( and B7 , but *induced* an up-regulation of CD25 , CD31 and vascular endothelial (VE)-cadherin expression and a down-regulation of [Mac-1] expression , by LC . Negative_regulation ITGB2 ICAM1 10807407 692189 The expression of CD11b and [CD18] on neutrophils and neutrophil dependent adhesion to endothelial cells elicited by HPE were inhibited by lansoprazole and omeprazole at clinical relevant doses , and the expression of and VCAM-1 on endothelial cells and endothelial dependent neutrophil adherence induced by IL-1beta were also *inhibited* by lansoprazole and omeprazole at similar doses . Negative_regulation ITGB2 ICAM1 11165259 782760 Specific phosphatidylinositol-3-kinase (PI3K) inhibitors suppressed both [LFA-1] activation and Rap1GTP generation , and abrogation of Rap1GTP by retroviral over-expression of a specific Rap1 GTPase activating protein , SPA-1 , totally *inhibited* the mediated cell adhesion . Negative_regulation ITGB2 ICAM1 9130650 426908 We have investigated the *role* of ligands ( and ICAM-3 ) in [LFA-1] activation by using ICAM blocking monoclonal antibodies and a fixation protocol for `` freezing '' LFA-1 on the surface of cells after prior exposure to ICAM-1 and ICAM-3 . Negative_regulation ITGB2 ICAM3 9130650 426909 We have investigated the *role* of ligands ( ICAM-1 and ) in [LFA-1] activation by using ICAM blocking monoclonal antibodies and a fixation protocol for `` freezing '' LFA-1 on the surface of cells after prior exposure to ICAM-1 and ICAM-3 . Negative_regulation ITGB2 IFNG 11896209 920861 Because IFN-gamma is an important cytokine during granulocytic ehrlichiosis and is known to activate leukocytes , we investigated the potential *role* of in [CD11b/CD18] up-regulation . Negative_regulation ITGB2 IL15 12969549 1139229 Interestingly , *stimulated* relatively low level of expression of [CD18] , a beta2 integrin molecule related to lymphocyte apoptosis in A-NK cells ( 11.45 % ) , whereas IL-2 exerted a strong effect on CD18 expression ( 87.54 % ) . Negative_regulation ITGB2 IL17D 20416175 2246564 *down-regulated* [Mac-1] expression in human neutrophils ( p < 0.05 ) . Negative_regulation ITGB2 IL1B 9142862 428548 During reoxygenation , both whole blood PMN phagocytosis and bactericidal activity were reduced in the presence of IL-8 , TNF-alpha , or , and in subsets of PMN with reduced phagocytosis H/R *reduced* CD64 , CD32w , CD16 , CD35 , and [CD11b/CD18] expression in the presence of each cytokine . Negative_regulation ITGB2 IL1B 9197378 438545 In addition , pretreatment of infected monocytes with a TNF-alpha synthesis inhibitor , RP 55778 , or with MAbs directed against IL-1beta , confirmed the *role* of TNF-alpha and in the regulation of [CD18] , CD44 , and CD54 expression . Negative_regulation ITGB2 IL8 9024987 405814 Thus the suppression of [CD11b/CD18] expression by tepoxalin may *involve* . Negative_regulation ITGB2 IL8 9142862 428549 During reoxygenation , both whole blood PMN phagocytosis and bactericidal activity were reduced in the *presence* of , TNF-alpha , or IL-1beta , and in subsets of PMN with reduced phagocytosis H/R reduced CD64 , CD32w , CD16 , CD35 , and [CD11b/CD18] expression in the presence of each cytokine . Negative_regulation ITGB2 ILK 9618871 510338 Thus , the [CD11b/CD18] heterodimer is apparently up regulated in *response* to the injected and plays a major role in the adherence of activated heterophils . Negative_regulation ITGB2 ITGAL 12662148 1074286 By binding to - the alpha-subunit of LFA-1 - [LFA-1] is *prevented* from binding with its ligand , intercellular adhesion molecule-1 ( ICAM-1 ) . Negative_regulation ITGB2 ITGAL 17053736 1636382 Binding of efalizumab to *prevents* binding of [LFA-1] to ICAM-1 , thus inhibiting several steps in the immunological process responsible for formation of psoriatic plaque ( activation of naive T lymphocytes to memory T lymphocytes , lymphocyte migration and reactivation of T lymphocytes in skin ) . Negative_regulation ITGB2 ITGAM 1683891 171569 Flow cytometry , immunoprecipitation , and mRNA analyses showed that cell activation with phorbol esters or with a variety of stimuli such as Staphylococcus aureus or anti-mu antibodies in combination with cytokines *induced* de novo [CD11c/CD18] cell surface expression on most B cells while expression was not affected . Negative_regulation ITGB2 JUN 12952972 1158091 In contrast , mAb *inhibited* the [Mac-1-GPIbalpha] interaction . Negative_regulation ITGB2 LPA 9068082 419007 In addition , the A23187 stimulated increase in PMN adherence to fibrinogen coated surfaces , mediated by [CD11b/CD18] , was virtually eliminated in the presence of rHDL and HDL , but not in the *presence* of apolipoprotein A-I or natural low density . Negative_regulation ITGB2 MAG 24107275 2852546 [Mac-1] ( CD11b/CD18 ) expression on the peripheral neutrophils , 27.1 ± 6.66 MFI ( mean fluorescence intensity ) before treatment , was *reduced* to 17.9 ± 3.02 MFI by ( P < 0.05 ) . Negative_regulation ITGB2 MAPK1 15739163 1389766 Moreover , the ability of fimbriae to activate [CD11b-CD18] was significantly *inhibited* by pharmacological inhibitors of phosphatidylinositol-3-kinase but not of PKC or of p38 . Negative_regulation ITGB2 MAPK1 20421794 2256499 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Negative_regulation ITGB2 MAPK10 15739163 1389767 Moreover , the ability of fimbriae to activate [CD11b-CD18] was significantly *inhibited* by pharmacological inhibitors of phosphatidylinositol-3-kinase but not of PKC or of p38 . Negative_regulation ITGB2 MAPK10 20421794 2256500 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Negative_regulation ITGB2 MAPK11 15739163 1389768 Moreover , the ability of fimbriae to activate [CD11b-CD18] was significantly *inhibited* by pharmacological inhibitors of phosphatidylinositol-3-kinase but not of PKC or of p38 . Negative_regulation ITGB2 MAPK11 20421794 2256501 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Negative_regulation ITGB2 MAPK12 15739163 1389769 Moreover , the ability of fimbriae to activate [CD11b-CD18] was significantly *inhibited* by pharmacological inhibitors of phosphatidylinositol-3-kinase but not of PKC or of p38 . Negative_regulation ITGB2 MAPK12 20421794 2256502 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Negative_regulation ITGB2 MAPK13 15739163 1389770 Moreover , the ability of fimbriae to activate [CD11b-CD18] was significantly *inhibited* by pharmacological inhibitors of phosphatidylinositol-3-kinase but not of PKC or of p38 . Negative_regulation ITGB2 MAPK13 20421794 2256503 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Negative_regulation ITGB2 MAPK14 15739163 1389771 Moreover , the ability of fimbriae to activate [CD11b-CD18] was significantly *inhibited* by pharmacological inhibitors of phosphatidylinositol-3-kinase but not of PKC or of p38 . Negative_regulation ITGB2 MAPK14 20421794 2256504 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Negative_regulation ITGB2 MAPK15 15739163 1389765 Moreover , the ability of fimbriae to activate [CD11b-CD18] was significantly *inhibited* by pharmacological inhibitors of phosphatidylinositol-3-kinase but not of PKC or of p38 . Negative_regulation ITGB2 MAPK15 20421794 2256498 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Negative_regulation ITGB2 MAPK3 15739163 1389772 Moreover , the ability of fimbriae to activate [CD11b-CD18] was significantly *inhibited* by pharmacological inhibitors of phosphatidylinositol-3-kinase but not of PKC or of p38 . Negative_regulation ITGB2 MAPK3 20421794 2256505 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Negative_regulation ITGB2 MAPK4 15739163 1389773 Moreover , the ability of fimbriae to activate [CD11b-CD18] was significantly *inhibited* by pharmacological inhibitors of phosphatidylinositol-3-kinase but not of PKC or of p38 . Negative_regulation ITGB2 MAPK4 20421794 2256506 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Negative_regulation ITGB2 MAPK6 15739163 1389774 Moreover , the ability of fimbriae to activate [CD11b-CD18] was significantly *inhibited* by pharmacological inhibitors of phosphatidylinositol-3-kinase but not of PKC or of p38 . Negative_regulation ITGB2 MAPK6 20421794 2256507 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Negative_regulation ITGB2 MAPK7 15739163 1389775 Moreover , the ability of fimbriae to activate [CD11b-CD18] was significantly *inhibited* by pharmacological inhibitors of phosphatidylinositol-3-kinase but not of PKC or of p38 . Negative_regulation ITGB2 MAPK7 20421794 2256508 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Negative_regulation ITGB2 MAPK8 15739163 1389776 Moreover , the ability of fimbriae to activate [CD11b-CD18] was significantly *inhibited* by pharmacological inhibitors of phosphatidylinositol-3-kinase but not of PKC or of p38 . Negative_regulation ITGB2 MAPK8 20421794 2256509 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Negative_regulation ITGB2 MAPK9 15739163 1389777 Moreover , the ability of fimbriae to activate [CD11b-CD18] was significantly *inhibited* by pharmacological inhibitors of phosphatidylinositol-3-kinase but not of PKC or of p38 . Negative_regulation ITGB2 MAPK9 20421794 2256510 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Negative_regulation ITGB2 MRE11A 10688643 670070 Furthermore , a dominant negative form of ( Rap1N17 ) *inhibited* T-cell receptor mediated [LFA-1] activation in Jurkat T cells and LFA-1/ICAM-1 dependent cell aggregation upon differentiation of HL-60 cells into macrophages , suggesting that Rap1 is critically involved in physiological processes . Negative_regulation ITGB2 NA 12163056 972310 Furthermore , also *down-regulated* [CD11a/LFA-1alpha] expression in both U937 cells and peripheral blood monocytes . Negative_regulation ITGB2 NCR1 16044078 1438013 NF-kappaB activation , [CD11b/CD18] expression , and the production of TNF-alpha , IL-8 , and IL-6 in monocytes and granulocytes were *inhibited* by in vitro . Negative_regulation ITGB2 NCR2 16044078 1438014 NF-kappaB activation , [CD11b/CD18] expression , and the production of TNF-alpha , IL-8 , and IL-6 in monocytes and granulocytes were *inhibited* by in vitro . Negative_regulation ITGB2 NCR3 16044078 1438012 NF-kappaB activation , [CD11b/CD18] expression , and the production of TNF-alpha , IL-8 , and IL-6 in monocytes and granulocytes were *inhibited* by in vitro . Negative_regulation ITGB2 NOS1 10880532 709202 IFN-gamma mediated apoptosis was abolished by depleting adherent cells or [Mac-1] ( + ) spleen cells or by *inhibiting* . Negative_regulation ITGB2 NOS2 10880532 709203 IFN-gamma mediated apoptosis was abolished by depleting adherent cells or [Mac-1] ( + ) spleen cells or by *inhibiting* . Negative_regulation ITGB2 NOS3 10880532 709204 IFN-gamma mediated apoptosis was abolished by depleting adherent cells or [Mac-1] ( + ) spleen cells or by *inhibiting* . Negative_regulation ITGB2 NUP153 1351048 188076 We conclude that ( 1 ) 15669 acts on neutrophils to block activation induced adherence , and ( 2 ) NPC 15669 *inhibits* the upregulation of the [CD11b/CD18] ( Mac-1 ) adhesion receptor . Negative_regulation ITGB2 NUP210 1351048 188075 We conclude that ( 1 ) NPC 15669 acts on neutrophils to block activation induced adherence , and ( 2 ) 15669 *inhibits* the upregulation of the [CD11b/CD18] ( Mac-1 ) adhesion receptor . Negative_regulation ITGB2 NUP214 1351048 188077 We conclude that ( 1 ) NPC 15669 acts on neutrophils to block activation induced adherence , and ( 2 ) 15669 *inhibits* the upregulation of the [CD11b/CD18] ( Mac-1 ) adhesion receptor . Negative_regulation ITGB2 NUP62 1351048 188078 We conclude that ( 1 ) 15669 acts on neutrophils to block activation induced adherence , and ( 2 ) NPC 15669 *inhibits* the upregulation of the [CD11b/CD18] ( Mac-1 ) adhesion receptor . Negative_regulation ITGB2 PARP1 10688643 670068 Furthermore , a dominant negative form of ( Rap1N17 ) *inhibited* T-cell receptor mediated [LFA-1] activation in Jurkat T cells and LFA-1/ICAM-1 dependent cell aggregation upon differentiation of HL-60 cells into macrophages , suggesting that Rap1 is critically involved in physiological processes . Negative_regulation ITGB2 PI3 10931873 720204 Further evidence demonstrated that activation of by PDGF *induced* a decrease in the association of alpha-actinin with the [integrin beta] subunit , and that PtdIns ( 3,4,5 ) -P ( 3 ) could disrupt this interaction in vitro . Negative_regulation ITGB2 PI3 8943387 400018 These results strongly suggest that CD4 induced activation , in the absence of concomitant TCR/CD3 triggering , *leads* to down-regulation of [LFA-1] mediated T cell adhesion to B cells . Negative_regulation ITGB2 PIK3CA 15739163 1389778 Moreover , the ability of fimbriae to activate [CD11b-CD18] was significantly *inhibited* by pharmacological inhibitors of but not of PKC or of p38 mitogen activated protein kinase . Negative_regulation ITGB2 PIK3R1 15739163 1389779 Moreover , the ability of fimbriae to activate [CD11b-CD18] was significantly *inhibited* by pharmacological inhibitors of but not of PKC or of p38 mitogen activated protein kinase . Negative_regulation ITGB2 PLG 16403785 1527136 Interestingly , the interaction between [Mac-1] and Lp(a) was strengthened in the presence of proatherogenic homocysteine and was *blocked* by kringle 4 . Negative_regulation ITGB2 PRKCZ 19086264 2003587 The objective of this study was to examine the *role* of in interleukin (IL)-8 mediated activation of [Mac-1] ( CD11b/CD18 ) in human neutrophils . Negative_regulation ITGB2 PTK2 7594504 334783 Inhibition of with genistein and herbimycin A *blocked* the ability of laminin to increase [CD11b/CD18] expression and EC3bi rosetting . Negative_regulation ITGB2 PTK6 7594504 334784 Inhibition of with genistein and herbimycin A *blocked* the ability of laminin to increase [CD11b/CD18] expression and EC3bi rosetting . Negative_regulation ITGB2 PTK7 7594504 334785 Inhibition of with genistein and herbimycin A *blocked* the ability of laminin to increase [CD11b/CD18] expression and EC3bi rosetting . Negative_regulation ITGB2 PTX3 7531948 291978 Butanol and also significantly *reduced* the upregulation of [CD11b/CD18] by f-methionyl-leucyl-phenylalanine ( fMLP ) and platelet activating factor (PAF) but not by phorbol myristate acetate ( PMA ) . Negative_regulation ITGB2 PTX4 7531948 291977 Butanol and also significantly *reduced* the upregulation of [CD11b/CD18] by f-methionyl-leucyl-phenylalanine ( fMLP ) and platelet activating factor (PAF) but not by phorbol myristate acetate ( PMA ) . Negative_regulation ITGB2 RAD50 10688643 670071 Furthermore , a dominant negative form of ( Rap1N17 ) *inhibited* T-cell receptor mediated [LFA-1] activation in Jurkat T cells and LFA-1/ICAM-1 dependent cell aggregation upon differentiation of HL-60 cells into macrophages , suggesting that Rap1 is critically involved in physiological processes . Negative_regulation ITGB2 RANBP2 1351048 188079 We conclude that ( 1 ) NPC 15669 acts on neutrophils to block activation induced adherence , and ( 2 ) 15669 *inhibits* the upregulation of the [CD11b/CD18] ( Mac-1 ) adhesion receptor . Negative_regulation ITGB2 RAP1A 11165259 782761 Specific phosphatidylinositol-3-kinase (PI3K) inhibitors suppressed both LFA-1 activation and generation , and abrogation of Rap1GTP by retroviral over-expression of a specific Rap1 GTPase activating protein , SPA-1 , totally *inhibited* the [LFA-1/ICAM-1] mediated cell adhesion . Negative_regulation ITGB2 RARA 8634442 357360 Moreover , an completely *inhibited* the expression of type II TGase and [CD18] induced by these selective retinoids in NB4 cells . Negative_regulation ITGB2 SELL 10095863 560673 Moreover , EM downregulated expression and *inhibited* interleukin (IL)-8 induced upregulation of [Mac-1] on peripheral blood neutrophils . Negative_regulation ITGB2 SELL 16415171 1527610 The binding of platelets to monocytes via P-selectin-PSGL-1 interactions was shown to *increase* expression and activity of alpha4beta1 and [alphaMbeta2integrin] , with a concomitant decrease in expression . Negative_regulation ITGB2 SELL 24127491 2858987 The complex signals through Src family kinases , ITAM domain containing adaptor proteins , and other kinases to ultimately *result* in [LFA-1] activation . Negative_regulation ITGB2 SELPLG 24127491 2858988 The complex signals through Src family kinases , ITAM domain containing adaptor proteins , and other kinases to ultimately *result* in [LFA-1] activation . Negative_regulation ITGB2 SOD1 8781538 380377 or catalase treatment decreased PMN accumulation in the reperfused heart and *prevented* the marked upregulation of [CD18] expression seen after reperfusion . Negative_regulation ITGB2 SOD2 8781538 380378 or catalase treatment decreased PMN accumulation in the reperfused heart and *prevented* the marked upregulation of [CD18] expression seen after reperfusion . Negative_regulation ITGB2 SOD3 8781538 380379 or catalase treatment decreased PMN accumulation in the reperfused heart and *prevented* the marked upregulation of [CD18] expression seen after reperfusion . Negative_regulation ITGB2 TERF2 10688643 670065 Furthermore , a dominant negative form of ( Rap1N17 ) *inhibited* T-cell receptor mediated [LFA-1] activation in Jurkat T cells and LFA-1/ICAM-1 dependent cell aggregation upon differentiation of HL-60 cells into macrophages , suggesting that Rap1 is critically involved in physiological processes . Negative_regulation ITGB2 TERF2IP 10688643 670067 Furthermore , a dominant negative form of ( Rap1N17 ) *inhibited* T-cell receptor mediated [LFA-1] activation in Jurkat T cells and LFA-1/ICAM-1 dependent cell aggregation upon differentiation of HL-60 cells into macrophages , suggesting that Rap1 is critically involved in physiological processes . Negative_regulation ITGB2 TLN1 19074766 2030647 Binding of the actin linking protein , talin , to [integrin beta] cytoplasmic tails ( CTs ) *induces* high affinity ligand binding ( integrin activation ) , whereas binding of another actin linking protein , filamin , to the integrin beta CTs negatively regulates this process by blocking the interaction . Negative_regulation ITGB2 TLN2 19074766 2030648 Binding of the actin linking protein , talin , to [integrin beta] cytoplasmic tails ( CTs ) *induces* high affinity ligand binding ( integrin activation ) , whereas binding of another actin linking protein , filamin , to the integrin beta CTs negatively regulates this process by blocking the interaction . Negative_regulation ITGB2 TMEM115 17988652 1850944 Moreover , specifically *inhibited* fMLP induced [Mac-1] expression without affecting this caused by LTB ( 4 ) or PMA . Negative_regulation ITGB2 TNF 9142862 428547 During reoxygenation , both whole blood PMN phagocytosis and bactericidal activity were reduced in the *presence* of IL-8 , , or IL-1beta , and in subsets of PMN with reduced phagocytosis H/R reduced CD64 , CD32w , CD16 , CD35 , and [CD11b/CD18] expression in the presence of each cytokine . Negative_regulation ITGB2 TNF 9197378 438544 In addition , pretreatment of infected monocytes with a TNF-alpha synthesis inhibitor , RP 55778 , or with MAbs directed against IL-1beta , confirmed the *role* of and IL-1beta in the regulation of [CD18] , CD44 , and CD54 expression . Negative_regulation ITGB2 TNMD 16270641 1479151 Analytical results showed that ( 1 ) ox-LDL furthered monocyte L-selectin shedding and [Mac-1] expression , and an attendant increase in TEM of monocyte , while treating the monocyte with Mac-1 antibody *inhibited* the ox-LDL promoted of monocyte ; Negative_regulation ITGB2 VCAM1 10807407 692188 The expression of CD11b and [CD18] on neutrophils and neutrophil dependent adhesion to endothelial cells elicited by HPE were inhibited by lansoprazole and omeprazole at clinical relevant doses , and the expression of ICAM-1 and on endothelial cells and endothelial dependent neutrophil adherence induced by IL-1beta were also *inhibited* by lansoprazole and omeprazole at similar doses . Negative_regulation ITGB2 VEGFA 10881945 709236 In addition , anti-GM-CSF MoAb , but not or anti-IL-8 MoAb , *reduced* PMN CD11b and [CD18] overexpression induced by tumour conditioned medium ( p < 0.05 ) . Negative_regulation ITGB2 XRCC5 10688643 670066 Furthermore , a dominant negative form of ( Rap1N17 ) *inhibited* T-cell receptor mediated [LFA-1] activation in Jurkat T cells and LFA-1/ICAM-1 dependent cell aggregation upon differentiation of HL-60 cells into macrophages , suggesting that Rap1 is critically involved in physiological processes . Negative_regulation ITGB2 XRCC6 10688643 670069 Furthermore , a dominant negative form of ( Rap1N17 ) *inhibited* T-cell receptor mediated [LFA-1] activation in Jurkat T cells and LFA-1/ICAM-1 dependent cell aggregation upon differentiation of HL-60 cells into macrophages , suggesting that Rap1 is critically involved in physiological processes . Negative_regulation ITGB3 PECAM1 10438720 634989 stimulation of HUVECs increased the adhesive function of alphavbeta3 integrin to its ligand RGD peptide , the binding of which reached a maximum at 10 minutes after the stimulation , and the CD31 induced [alphavbeta3 integrin] activation on HUVECs was *inhibited* by inhibitors of protein kinase C and phosphatidylinositol 3 kinase ( PI3-kinase ) . Negative_regulation ITGB3 TNF 15345499 1366574 *reduced* the expression of [CD61] and the adhesion to COMP , but did not reverse the adhesion once it had taken place . Negative_regulation ITIH4 MUC16 8794290 381121 The chimeric peptide could also *inhibit* monoclonal antibody binding to native [gp120] captured from virus particles . Negative_regulation ITIH4 TNF 9343827 459048 CRDS treatment of cells not only inhibited the binding of HIV-1 [gp120] to CD4+ cells , but also *inhibited* production induced by gp120 . Negative_regulation ITK GNE 24918870 2946632 This effort culminated in identification of a potent and selective [ITK] *inhibitor* ( ) with good ADME properties in preclinical species . Negative_regulation IVL SPHK1 18385762 1944172 In addition , K6PC-5 enhanced the expression of involucrin and filaggrin , specific differentiation associated marker proteins in HaCaT cells , whereas transfection of *blocked* the increase of [involucrin] . Negative_regulation IVL TGM2 2458856 96431 If replication was arrested with hydroxyurea prior to confluence , induction occurred within several days but [involucrin] levels were completely *suppressed* . Negative_regulation IVL TGM2 7696177 287966 Analysis of additional tumor cell lines indicated that the expression of transglutaminase I and [involucrin] are under separate genetic control and that loss of activity can *result* either from a lack of protein or from a defect in the activation step . Negative_regulation JAG1 AGTR1 24410155 2938070 Radiosurgery enhanced apoptotic activity ( p < 0.05 ) and *inhibited* the expression of Notch1 and Notch4 receptors and [Jagged1] in the endothelial cells of nidus vessels in the AVF rats , 2 , 3 , 7 , 21 , 28 , and 42 days postradiosurgery ( p < 0.05 ) . Negative_regulation JAG1 CD4 19535638 2098920 [Ags] characterizing tumors or chronic viral infection are generally presented to the host immune system before specific immunotherapy is initiated , and consequent generation of regulatory ( + ) T cells can *inhibit* induction of desired effector CD8 T cell responses . Negative_regulation JAG1 CD8A 19535638 2098921 [Ags] characterizing tumors or chronic viral infection are generally presented to the host immune system before specific immunotherapy is initiated , and consequent generation of regulatory CD4 ( + ) T cells can *inhibit* induction of desired effector T cell responses . Negative_regulation JAG1 CD8B 19535638 2098922 [Ags] characterizing tumors or chronic viral infection are generally presented to the host immune system before specific immunotherapy is initiated , and consequent generation of regulatory CD4 ( + ) T cells can *inhibit* induction of desired effector T cell responses . Negative_regulation JAG1 CDX2 20199401 2237022 also *down-regulated* transcription of the Shh gene in the human gastric carcinoma cell lines [AGS] , MKN45 and MKN74 . Negative_regulation JAG1 CYP21A2 1674383 157929 The [adrenogenital syndrome (AGS)] is usually *caused* by deficiency . Negative_regulation JAG1 FGF2 20436223 2256760 The study analyzed the signalling pathways involved in the regulation of [Jagged-1/Notch-4] expression in endothelial cells ( HUVECs ) in *response* to VEGF , and PPAR-gamma exogenous activator - ciglitazone . Negative_regulation JAG1 HEY2 15389319 1300392 To clarify the *role* of in human CHD and [AGS] , we screened by direct sequencing 23 children with CHD and 38 patients diagnosed with AGS , which lack mutations in the JAG1 gene . Negative_regulation JAG1 IL33 21667014 2455325 *induced* a significant decrease in [Jag1] and Dll4 mRNA expression in the mucosa of the control mice . Negative_regulation JAG1 MYLIP 22618231 2620056 We demonstrate ( by ablation of the miR-21 binding site in the JAG1 3'UTR ) that directly targets and *represses* [JAG1] levels in MCF-7 ( ER+ ) breast cancer cells . Negative_regulation JAG1 NFKBIA 10329626 613629 Importantly , [jagged1] transcripts were also upregulated by endogenous NF-kappaB activation and this effect was *inhibited* by a dominant mutant of , a physiological inhibitor of NF-kappaB . Negative_regulation JAG1 NOTCH1 20798046 2318189 Activation of in isolated nonsensory cells *results* in lateral induction of [Jag1] expression in neighboring cells and spreading of prosensory specification to the adjacent cells through an intercellular mechanism . Negative_regulation JAG1 NOTCH1 20940224 2332860 Epidermal activation *resulted* in upregulation of [jagged 1] in both epidermis and dermis . Negative_regulation JAG1 NOTCH1 23752887 2801926 Renal involvement and the *role* of signalling in [Alagille syndrome] . Negative_regulation JAG1 NOTCH2 20798046 2318190 Activation of in isolated nonsensory cells *results* in lateral induction of [Jag1] expression in neighboring cells and spreading of prosensory specification to the adjacent cells through an intercellular mechanism . Negative_regulation JAG1 NOTCH2 20940224 2332861 Epidermal activation *resulted* in upregulation of [jagged 1] in both epidermis and dermis . Negative_regulation JAG1 NOTCH2 23752887 2801927 Renal involvement and the *role* of signalling in [Alagille syndrome] . Negative_regulation JAG1 NOTCH3 20798046 2318191 Activation of in isolated nonsensory cells *results* in lateral induction of [Jag1] expression in neighboring cells and spreading of prosensory specification to the adjacent cells through an intercellular mechanism . Negative_regulation JAG1 NOTCH3 20940224 2332862 Epidermal activation *resulted* in upregulation of [jagged 1] in both epidermis and dermis . Negative_regulation JAG1 NOTCH3 23752887 2801928 Renal involvement and the *role* of signalling in [Alagille syndrome] . Negative_regulation JAG1 NOTCH3 25100656 2954325 and Rbpj *block* co-expression of [Jag1] and Neurog2 , while specifically stimulating Pax6 within an adjacent domain . Negative_regulation JAG1 NOTCH4 20798046 2318192 Activation of in isolated nonsensory cells *results* in lateral induction of [Jag1] expression in neighboring cells and spreading of prosensory specification to the adjacent cells through an intercellular mechanism . Negative_regulation JAG1 NOTCH4 20940224 2332863 Epidermal activation *resulted* in upregulation of [jagged 1] in both epidermis and dermis . Negative_regulation JAG1 NOTCH4 23752887 2801929 Renal involvement and the *role* of signalling in [Alagille syndrome] . Negative_regulation JAG1 PCGF2 22954590 2701747 Furthermore , our data showed that blockade *up-regulated* the expression of the Wnt/TCF target [Jagged-1] , a Notch ligand , and consequently activated the Notch pathway . Negative_regulation JAG1 PPARG 20436223 2256761 The study analyzed the signalling pathways involved in the regulation of [Jagged-1/Notch-4] expression in endothelial cells ( HUVECs ) in *response* to VEGF , bFGF and exogenous activator - ciglitazone . Negative_regulation JAG1 PRH1 15919063 1420402 These neurophysiological and microinjection findings support a critical *role* of in generation of this [AGS] kindling induced convulsive behavior . Negative_regulation JAG1 PRH2 15919063 1420403 These neurophysiological and microinjection findings support a critical *role* of in generation of this [AGS] kindling induced convulsive behavior . Negative_regulation JAG1 PSENEN 17967789 1826510 Furthermore , the expression of the cardiac marker protein alpha-sarcomeric actinin and troponin T was significantly suppressed by *inhibition* or addition of soluble recombinant [Jagged-1] , indicating that Notch activation facilitates cardiac marker gene expression . Negative_regulation JAG1 RBPJ 25100656 2954324 Notch3 and *block* co-expression of [Jag1] and Neurog2 , while specifically stimulating Pax6 within an adjacent domain . Negative_regulation JAG1 RUNX3 21637926 2450930 Reporter assays , ChIP assays and EMSAs revealed that directly bound to the transcriptional regulatory region of JAG1 and *suppressed* [JAG1] transcription . Negative_regulation JAG1 RUNX3 21637926 2450931 expression *suppressed* [JAG1] expression and resulted in downregulation of tumorigenesis by suppression of JAG1 mediated CSCs . Negative_regulation JAG1 SPAST 18495362 1921850 However , contrary to Taxol , [Jagged1] *induced* downregulation of the microtubule severing protein . Negative_regulation JAG1 TGFB1 20169621 2242616 Downstream , activated Smad dependent signaling , and Smad independent pathways that included PI3 kinase , p38 , and JNK MAP kinase , but only inhibition of the Smad dependent pathway *blocked* [Jagged1] expression . Negative_regulation JAK1 EPHB2 16291589 1526002 TCCM treatment activated p38 mitogen activated protein kinase (MAPK) and [Janus kinase (JNK)] but *inhibited* . Negative_regulation JAK1 EPHB2 16686690 1560226 These data suggest that the cascade functions downstream of Rac GTPase to actively *repress* pro-apoptotic [JAK/STAT] signaling in healthy CGNs . Negative_regulation JAK1 EPHB2 9736697 531352 These results demonstrate an *mediated* mechanism for inhibiting IL-6 induced [Jak-STAT] signaling that is rapid and inducible , and thus differs from previously described mechanisms for downmodulation of the Jak-STAT pathway . Negative_regulation JAK1 MAP2K6 16686690 1560232 These data suggest that the cascade functions downstream of Rac GTPase to actively *repress* pro-apoptotic [JAK/STAT] signaling in healthy CGNs . Negative_regulation JAK1 MAP2K6 20703093 2317686 In this hypothetical model JAK suppresses phosphorylation and nuclear re-localization , but [JAK] inhibition *induces* the phosphorylations and relocalization with association of RAF and phosphorylated BubR1 in the nucleus leading to endoreduplication . Negative_regulation JAK1 TLR7 24251781 2903841 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , PI3K/AkT inhibition , IKK/JNK inhibition , mTORC1 inhibition , [JAK/STAT] *inhibition* , suppression , and ACE inhibition . Negative_regulation JAK2 CCND1 22174819 2518343 Mechanistic characterization revealed that NSC-743380 suppressed the phosphorylation of C-terminal domain of RNA polymerase II , induced JNK activation , *inhibited* [JAK2/STAT3] phosphorylation and suppressed expression in sensitive human cancer cells . Negative_regulation JAK2 EPHB2 16051699 1466166 IFNgamma up-regulation of CFTR in mast cells was inhibited by p38 and extracellular signal regulated kinase ( ) kinase inhibitors but not a [Janus tyrosine kinase (JAK)2] *inhibitor* , whereas in T84 cells IFNgamma mediated down-regulation of CFTR was JAK2 dependent and ERK- and p38 independent . Negative_regulation JAK2 EPHB2 16291589 1526003 TCCM treatment activated p38 mitogen activated protein kinase (MAPK) and [Janus kinase (JNK)] but *inhibited* . Negative_regulation JAK2 EPHB2 16686690 1560234 These data suggest that the cascade functions downstream of Rac GTPase to actively *repress* pro-apoptotic [JAK/STAT] signaling in healthy CGNs . Negative_regulation JAK2 EPHB2 9736697 531353 These results demonstrate an *mediated* mechanism for inhibiting IL-6 induced [Jak-STAT] signaling that is rapid and inducible , and thus differs from previously described mechanisms for downmodulation of the Jak-STAT pathway . Negative_regulation JAK2 MAP2K6 16686690 1560240 These data suggest that the cascade functions downstream of Rac GTPase to actively *repress* pro-apoptotic [JAK/STAT] signaling in healthy CGNs . Negative_regulation JAK2 MAP2K6 20703093 2317693 In this hypothetical model JAK suppresses phosphorylation and nuclear re-localization , but [JAK] inhibition *induces* the phosphorylations and relocalization with association of RAF and phosphorylated BubR1 in the nucleus leading to endoreduplication . Negative_regulation JAK2 TLR7 24251781 2903869 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , PI3K/AkT inhibition , IKK/JNK inhibition , mTORC1 inhibition , [JAK/STAT] *inhibition* , suppression , and ACE inhibition . Negative_regulation JAK2 TNF 16574984 1568539 *attenuated* [JAK2/STAT5] and ERK1/2 phosphorylation and IGF-I and Spi 2.1 mRNA expression following GH stimulation . Negative_regulation JAK2 TNFSF10 19564891 2129037 In parallel , the treatment with and Tyrphostin ( AG-490 ) , a selective [Janus kinase 2] *inhibitor* , produces an evident enhancement of cytotoxicity , characterized by a significant inhibition of Stat3 phosphorylation compared to controls or to TRAIL alone treated samples , and associated with a dramatic decrease of both cIAP-1 and cIAP-2 mRNA levels . Negative_regulation JAK3 EPHB2 16291589 1526004 TCCM treatment activated p38 mitogen activated protein kinase (MAPK) and [Janus kinase (JNK)] but *inhibited* . Negative_regulation JAK3 EPHB2 16686690 1560242 These data suggest that the cascade functions downstream of Rac GTPase to actively *repress* pro-apoptotic [JAK/STAT] signaling in healthy CGNs . Negative_regulation JAK3 EPHB2 9736697 531354 These results demonstrate an *mediated* mechanism for inhibiting IL-6 induced [Jak-STAT] signaling that is rapid and inducible , and thus differs from previously described mechanisms for downmodulation of the Jak-STAT pathway . Negative_regulation JAK3 MAP2K6 16686690 1560248 These data suggest that the cascade functions downstream of Rac GTPase to actively *repress* pro-apoptotic [JAK/STAT] signaling in healthy CGNs . Negative_regulation JAK3 MAP2K6 20703093 2317700 In this hypothetical model JAK suppresses phosphorylation and nuclear re-localization , but [JAK] inhibition *induces* the phosphorylations and relocalization with association of RAF and phosphorylated BubR1 in the nucleus leading to endoreduplication . Negative_regulation JAK3 TLR7 24251781 2903897 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , PI3K/AkT inhibition , IKK/JNK inhibition , mTORC1 inhibition , [JAK/STAT] *inhibition* , suppression , and ACE inhibition . Negative_regulation JUN ABCA12 21622130 2436413 Overexpression of significantly *increased* [AP-1] transcriptional activity . Negative_regulation JUN ALOX5 12859962 1111146 This report documents the fact that inhibition of *induces* rapid activation of [c-Jun N-terminal kinase (JNK)] in human prostate cancer cells which is prevented by the 5-lipoxygenase metabolite , 5 ( S ) -HETE . Negative_regulation JUN CCND1 12243339 990361 These results suggest that merlin inhibits abnormal cell proliferation which is activated via Ras by repressing Rb phosphorylation , blocking the increase of the protein level , and *inhibiting* the activation of [AP-1-] and E2F-1 dependent transcription in NIH3T3 cells . Negative_regulation JUN CCND1 19504174 2157244 Signaling analysis data further demonstrated that myricetin *inhibited* Akt mediated [activator protein-1 (AP-1)] transactivation , expression and cell transformation . Negative_regulation JUN CCND1 20596608 2286037 Pre-treatment of NS3 protein expressing cells with ERK inhibitor , PD98059 , blocked the activation of [AP-1] and NF-kappaB , and *inhibited* expression and cell proliferation . Negative_regulation JUN CCND1 22727408 2713470 BLU inhibits clonogenic growth of nasopharyngeal carcinoma cells , arrests cell cycle at G1 phase , downregulates JNK and promoter activities , and *inhibits* phosphorylation of [c-Jun] . Negative_regulation JUN CDC42EP5 10490598 645485 also *inhibited* [Jun] kinase activity by a mechanism that was independent of Cdc42 binding . Negative_regulation JUN CDKN1C 12963725 1164288 We here report that physically interacts with and *inhibits* [c-Jun] NH2-terminal kinase/stress activated protein kinase ( JNK/SAPK ) . Negative_regulation JUN CTGF 23906792 2866079 Furthermore , stimulation of cells with the *resulted* in increases in [AP-1-luciferase] activity ; Negative_regulation JUN EPHB2 10078562 595409 Stretch induced activation of was inhibited by herbimycin A , a tyrosine kinase inhibitor , but not by GF109203X or calphostin C , the inhibitors of protein kinase C. Mechanical stretch also *enhanced* DNA binding activity of [AP-1] , and this enhancement was inhibited by PD98059 , an inhibitor of MAPK or ERK kinase (MEK) . Negative_regulation JUN EPHB2 11401854 824660 The biological relevance of ERK activation by TGF-beta was indicated by demonstrating that inhibition of signaling by PD-98059 *blocked* the ability of TGF-beta to activate the transcription factor [activator protein-1] . Negative_regulation JUN EPHB2 11695993 877177 In contrast with 18 : 1 ( n-9 ) NAE and anandamide , the cannabinoid receptor agonist WIN 55,212-2 did not stimulate [AP-1] activity and *inhibited* phosphorylation . Negative_regulation JUN EPHB2 12594266 1060832 Interestingly , transient activation *resulted* in altered [AP-1] DNA binding activity and the induction of an AP-1 complex that was devoid of Fos protein and consisted of Jun-Jun dimers . Negative_regulation JUN EPHB2 12595493 1061596 Furthermore , Ad-DN-JNK or Ad-DN-p38 , but not , *attenuated* PDGF-BB induced [AP-1] activation in MC , indicating the involvement of JNK and p38 in AP-1 activation . Negative_regulation JUN EPHB2 14729583 1235004 In order to clarify the *roles* of p38 and in TPA induced [AP-1] activation , we utilized the pharmacologic inhibitors of these enzymes . Negative_regulation JUN EPHB2 16328781 1511921 The c-Jun mRNA , which is also driven by AP-1 , was also induced by HBO , and the induction of [c-Jun] was *blocked* by and JNK inhibitors . Negative_regulation JUN EPHB2 17473425 1738339 KIOM-79 inhibited activation of induced by STZ and *inhibited* DNA binding activity of an [activator protein-1 (AP-1)] , a downstream transcription factor of ERK . Negative_regulation JUN EPHB2 17908424 1803314 Moreover , B ( a ) P-induced activation of [c-Jun] was *inhibited* by stable expression of dominant negative mutants of JNK or , but not by dominant negative mutant of p38 . Negative_regulation JUN EPHB2 17941091 1866508 p38 inhibitor , SB203580 or JNK inhibitor , SP600125 but not inhibitor , PD98059 *attenuated* the US-induced MMP-13 , c-Fos , and [c-Jun] expression ; Negative_regulation JUN EPHB2 18302882 1873509 Furthermore we found expression of dominant negative mutant of and JNK *impaired* silica induced [AP-1] activation , whereas , dominant negative mutant of p38 did not show the effect . Negative_regulation JUN EPHB2 18621373 2034289 Pretreatment with extracellular signal regulated kinase ( ) and [Jun N-terminal kinase (JNK)] *inhibitors* , but not p38 mitogen activated protein kinase ( p38MAPK ) significantly decreased CRP induced superoxide anion release from macrophages in vivo . Negative_regulation JUN EPHB2 19627209 2112767 Moreover , inhibition of phosphorylated , JNK , and p38 by K. pandurata extract *resulted* in decreased c-Fos expression and [c-Jun] phosphorylation induced by UV light . Negative_regulation JUN EPHB2 20121399 2206935 In primary monocytes , and p38 inhibition *increased* binding of [AP-1] and Sp1 , respectively , to the IL-12p40 promoter , while JNK inhibition increased NF-kappaB , AP-1 , and Sp1 binding . Negative_regulation JUN EPHB2 20458747 2307551 *Activation* of extracellular signal regulated kinase ( ERK ) and [c-Jun-N-terminal kinase (JNK)] by TPA was identified , and TPA induced migration and MMP-9 activity was significantly blocked by inhibitor PD98059 and U0126 , but not JNK inhibitor SP600125 . Negative_regulation JUN EPHB2 20615395 2309884 GDNF induced MMP-13 expression and glioma migration were attenuated by MEK/extracellular signal regulating kinase ( ) and [c-Jun N-terminal protein kinase (JNK)] *inhibitors* , as well as ERK and JNK dominant negative mutants . Negative_regulation JUN EPHB2 21170925 2521312 In CT-26 cells , the extracellular signal regulated kinase ( ) inhibitor inhibited cell proliferation , invasion and MMP-9 expression , and the [c-Jun N-terminal kinase (JNK)] inhibitor *suppressed* the expression of both MMPs , as well as cell proliferation and cell invasion . Negative_regulation JUN EPHB2 21211365 2359501 Transfected recombinant elafin reduced MUC5AC protein ( 0.71 ± 0.04 ) mg/L and mRNA level ( 0.81 ± 0.04 ) , decreased p-JNK ( 0.38 ± 0.04 ) microg/mg and ( 0.31 ± 0.04 ) µg/mg production , *inhibited* [AP-1] activity ( 2.60 ± 0.19 ) and NF-?B activity ( 2.55 ± 0.21 ) , but increased I?Ba protein ( 0.54 ± 0.03 ) µg/mg , compared with single CSE stimulated group ( all P < 0.05 ) . Negative_regulation JUN EPHB2 8642312 362945 Our results suggest that defects in both JNK and may *result* in the decreased [AP-1] activity and the reduced IL-2 transcription observed in anergic T cells . Negative_regulation JUN EPHB2 9573527 502453 We have reported that both extracellular signal regulated kinase ( ERK ) and [c-Jun NH2-terminal kinase (JNK)] are *activated* by ET-1 and ET-1 induced activation of is inhibited by ANP . Negative_regulation JUN FAS 21257927 2469707 activation *resulted* in phosphorylation of the mitogen activated kinases extracellular signal regulated kinase ( ERK ) and [c-Jun-N-terminal kinase (JNK)] , and pharmacologic inhibition of ERK and JNK attenuated KC release in a dose-response manner . Negative_regulation JUN FAS 8562955 349058 Further , in normal and CD45- or Lck-deficient cell lines , stimulation *results* in activation of [Jun kinase (JNK)] , a proposed mediator of stress activation pathways . Negative_regulation JUN FBXO32 19117950 2036977 Overexpression of *increased* phosphorylation of JNK and [c-Jun] and decreased phosphorylation of Foxo3a . Negative_regulation JUN HBEGF 21289053 2410029 and ADAM17 siRNA also *prevented* [AP-1] activation . Negative_regulation JUN HES2 15836676 1397677 Similarly , could *inhibit* hepatic NF-kappaB and [AP-1] activations . Negative_regulation JUN HES2 15943182 1415826 also down-regulated pulmonary proinflammatory cytokines ( TNF-alpha , IL-1beta , and IL-6 ) and mRNA expressions ( CINC and P-selectin ) , and *inhibited* pulmonary activities of NF-kappaB and [AP-1] . Negative_regulation JUN HES2 16104441 1444714 also decreased the number of MPO positive cells induced by LPS and *inhibited* activation of NF-kappaB and [AP-1] . Negative_regulation JUN HES2 19166983 2038575 However , but not BL could *attenuate* the increase in MDA level and GSSH/GSH ratio and [AP-1] activation . Negative_regulation JUN IL1B 16729332 1565785 and CDCA *reduced* CYP7A1 but induced [c-Jun] messenger RNA expression in human primary hepatocytes . Negative_regulation JUN IL1B 19723085 2133846 We found that omega-3 fatty acids , such as docosahexaenoic acid ( DHA ) and alpha-linolenic acid ( ALA ) , suppressed the expression of inflammatory cytokines ( , IL-6 ) and *inhibited* the activation of transcription factor [activator protein-1] in cerulein stimulated pancreatic acinar cells . Negative_regulation JUN IL1B 19748795 2153107 ZD 7155 also reduced the mRNA expression of TNF-alpha and , *inhibited* the activation of NF-kappaB and [AP-1] , and improved lung histopathology . Negative_regulation JUN MAP2K6 10439045 635232 gamma-GCS also abolished the activation of [AP-1] induced by TNF and *inhibited* TNF induced activation of JNK and . Negative_regulation JUN MAP2K6 18381422 1892856 [c-Jun] NH2-terminal kinase activating kinase <1/mitogen activated protein kinase kinase> 4-mediated *inhibition* of SKOV3ip.1 ovarian cancer metastasis involves growth arrest and p21 up-regulation . Negative_regulation JUN MAP2K6 19350575 2057630 and JNK inhibitors *suppressed* PRL- or PRL-plus-IL-17 induced CCL20 production and [AP-1] activities . Negative_regulation JUN MAP2K6 19494289 2091589 ASC mediated [AP-1] activation was *inhibited* by chemical or protein inhibitors for caspase-8 , caspase-8 targeting small interfering RNA , and p38 and JNK inhibitors , but not by a caspase-1 inhibitor , caspase-9 or Fas associated death domain protein ( FADD ) dominant negative mutants , FADD- or RICK targeting small interfering RNAs , or a inhibitor , indicating that the ASC induced AP-1 activation is mediated by caspase-8 , p38 , and JNK , but does not require caspase-1 , caspase-9 , FADD , RICK , or ERK . Negative_regulation JUN MAP2K6 23274856 2758057 CTGF mediated increase of NF-?B and [AP-1] luciferase activity was *inhibited* by FAK , , and ERK inhibitors or mutants . Negative_regulation JUN MAP2K6 8065356 269050 Coexpression of an interfering , which inhibited AP-1 activation by small t and BXB , did not *inhibit* the activation of [AP-1] caused by small t and ERK1 . Negative_regulation JUN MAP2K6 8637721 362405 The over-expression of MUK or in NIH3T3 or COS1 cells *results* in the activation of JNK1 and the accumulation of a hyper phosphorylated form of [c-Jun] . Negative_regulation JUN MAP2K6 9873633 557013 U0126 can undergo isomerization and cyclization reactions to form a variety of products , both chemically and in vivo , all of which exhibit less affinity for and lower *inhibition* of [AP-1] activity than parent , U0126 . Negative_regulation JUN MMP7 17928719 1813351 Although CUR abolished the EGCG upregulated mRNA expression , it unexpectedly *enhanced* the [AP-1] activity by 502 % , suggesting that this factor may disrupt the MMP-7 mRNA stabilization process . Negative_regulation JUN MUC16 15162440 1253026 Furthermore , AgC10 inhibition must lie upstream in the MAPK activation pathway by LPS , since this also *inhibited* extracellularly regulated kinase (ERK) and [Jun kinase (JNK)activation] . Negative_regulation JUN RARB 10336422 615337 Our data showed that LE135 and LE540 strongly repressed 12-O-tetradecanoylphorbol-13-acetate induced [AP-1] activity in the *presence* of and RXRalpha . Negative_regulation JUN RARB 10771516 686184 Murine displays *reduced* transactivation activity , lower affinity for retinoic acid , and no [anti-AP1] activity . Negative_regulation JUN RARB 10771516 686185 The results demonstrate that , beta2 , and beta3 bind RA with a similar K ( d ) value , have a similar EC ( 50 ) value in RA-dependent transactivation assays and *inhibit* [AP1] activity to a similar level . Negative_regulation JUN RARB 12009305 940782 It is therefore concluded that both RARalpha and are mediators in the anticancer function of ATRA via AP-1 activity inhibition , and that RARbeta , not RARalpha , can *inhibit* [AP-1] activity to a certain extent directly by itself . Negative_regulation JUN RCAN1 23150431 2751916 The expression of *caused* an inhibition of the H ( 2 ) O ( 2 ) -induced activation of mitogen activated protein kinases ( MAPKs ) and [AP-1] . Negative_regulation JUN SPHK1 21998146 2513102 Finally , by inhibiting SphK1 activity , both N , N-dimethylsphingosine and ( G82D ) markedly *attenuated* the HG-induced [AP-1] activity . Negative_regulation JUN TNF 10439045 635226 gamma-GCS also abolished the activation of [AP-1] induced by TNF and *inhibited* induced activation of JNK and mitogen activated protein kinase kinase . Negative_regulation JUN TNF 10820260 694377 Vesnarinone also blocked NF-kappa B activation induced by several other inflammatory agents , *inhibited* the TNF induced activation of [transcription factor AP-1] , and suppressed the induced activation of c-Jun N-terminal kinase and mitogen activated protein kinase kinase . Negative_regulation JUN TNF 10919658 717268 Oleandrin also blocked [AP-1] activation induced by TNF and other agents and *inhibited* the induced activation of c-Jun NH2-terminal kinase . Negative_regulation JUN TNF 11675405 873237 The increase in was attenuated by both a p42/p44 inhibitor , PD098059 ( 10 ( -6 ) M ) , and a p38 inhibitor , SB203580 ( 10 ( -6 ) M ) , and [AP-1] binding activity was *inhibited* by PD098059 . Negative_regulation JUN TNF 15033544 1223533 and NAC partially *inhibited* [AP-1] activation . Negative_regulation JUN TNF 16536903 1536569 Addition of meloxicam into synovial fibroblast cultures inhibited dose-dependently mRNA expression for MMPs and TIMPs , which were *increased* by stimulation , through the suppression of NF-kappaB and [AP-1] activation . Negative_regulation JUN TNF 17015619 1629444 Consistent with this , FIP200 KO mouse embryo fibroblasts and liver cells showed increased apoptosis and reduced [c-Jun] N-terminal kinase phosphorylation in *response* to alpha stimulation , which might be mediated by FIP200 interaction with apoptosis signal regulating kinase 1 ( ASK1 ) and TNF receptor associated factor 2 (TRAF2) , regulation of TRAF2-ASK1 interaction , and ASK1 phosphorylation . Negative_regulation JUN TNF 17189827 1680099 Stimulation of cells with *resulted* in the activation of mitogen activated protein kinases (MAPK) such as [c-Jun N-terminal kinase (JNK)] and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Negative_regulation JUN TNF 18606807 1959546 We found that [c-Jun] was decreased in TAK1-deficient keratinocytes and that ectopic expression of c-Jun could partially *inhibit* induced increase of ROS and cell death . Negative_regulation JUN TNF 19748795 2153106 ZD 7155 also reduced the mRNA expression of and IL-1 beta , *inhibited* the activation of NF-kappaB and [AP-1] , and improved lung histopathology . Negative_regulation JUN TNF 21320636 2426264 The results showed that the NASH model rats reproduced typical pathogenetic and histopathological features of NASH in human , and genistein administration improved liver function , slowed down NASH progression , decreased the levels of TBARS , and IL-6 in serum and liver , as well as inhibited I?B-a phosphorylation , nuclear translocation of NF-?B p65 subunit , and *activation* of [c-Jun N-terminal kinase (JNK)] . Negative_regulation JUN TNF 9531270 496766 Overexpression of the p80 receptor *leads* to TNF dependent apoptosis , nuclear factor-kappa B activation , and [c-Jun] kinase activation . Negative_regulation JUNB FAS 21190961 2378968 BCL-6 decreased and inducible nitric oxide synthase expression and nitric oxide production , but it *inhibited* the expression of the antiapoptotic proteins Bcl-2 and [JunB] while increasing the expression of the proapoptotic death protein 5 . Negative_regulation KAT2B TNF 22219331 2544471 Inhibition of miR-181a/b function with anti-miRs blocked *induced* suppression of [PCAF] expression . Negative_regulation KCNA1 TLR7 20730378 2313312 Selective inhibitors of [Kv11] .1 regulate IL-6 expression by macrophages in *response* to ligands . Negative_regulation KCNA5 KCNE1 12574152 1057797 Microarray analysis revealed that hypothyroidism *induces* significant reductions in [KCNA5] , KCNB1 , KCND2 , and KCNK2 transcripts , whereas KCNQ1 and expression is increased . Negative_regulation KCND2 KCNE1 12574152 1057799 Microarray analysis revealed that hypothyroidism *induces* significant reductions in KCNA5 , KCNB1 , [KCND2] , and KCNK2 transcripts , whereas KCNQ1 and expression is increased . Negative_regulation KCNE1 KCNE2 17161791 1661914 However , *reduces* KCNQ1 current amplitude whereas [KCNE1] increases it , and KCNE2 induces a constitutively active KCNQ1 component whereas KCNE1 does not . Negative_regulation KCNH4 MAP2K6 9813041 546125 Blocking activation *prevented* GH-induced phosphorylation of [Elk-1] , as well as the ability of Elk-1 to mediate transcriptional activation in response to GH . Negative_regulation KCNK2 KCNE1 12574152 1057801 Microarray analysis revealed that hypothyroidism *induces* significant reductions in KCNA5 , KCNB1 , KCND2 , and [KCNK2] transcripts , whereas KCNQ1 and expression is increased . Negative_regulation KCNK3 CDC73 12003807 939889 In conclusion , *blocks* [TASK-1] or a closely related channel , the effect is PKC dependent , and the inhibition alters the electrical activity of myocytes in ways that would be arrhythmogenic in the intact heart . Negative_regulation KCNK3 CTR9 12003807 939890 In conclusion , *blocks* [TASK-1] or a closely related channel , the effect is PKC dependent , and the inhibition alters the electrical activity of myocytes in ways that would be arrhythmogenic in the intact heart . Negative_regulation KCNK3 EDN1 19188660 2127796 *inhibits* background two-pore domain channel [TASK-1] in primary human pulmonary artery smooth muscle cells . Negative_regulation KCNK3 HSPG2 22977011 2716097 Our results show that I ( TASK ) in rat cardiomyocytes is controlled by endothelin-1 and suggest that the inhibition of [TASK-1] via endothelin receptors is *mediated* by the activation of . Negative_regulation KCNK3 LEO1 12003807 939893 In conclusion , *blocks* [TASK-1] or a closely related channel , the effect is PKC dependent , and the inhibition alters the electrical activity of myocytes in ways that would be arrhythmogenic in the intact heart . Negative_regulation KCNK3 PAF1 12003807 939891 In conclusion , *blocks* [TASK-1] or a closely related channel , the effect is PKC dependent , and the inhibition alters the electrical activity of myocytes in ways that would be arrhythmogenic in the intact heart . Negative_regulation KCNK3 WDR61 12003807 939892 In conclusion , *blocks* [TASK-1] or a closely related channel , the effect is PKC dependent , and the inhibition alters the electrical activity of myocytes in ways that would be arrhythmogenic in the intact heart . Negative_regulation KCNMA1 EPHB2 23673010 2810966 Similar results were obtained in experiments performed in the native tissue in which inhibition of and p38 MAPK *increased* [BK channel] activity in the cortical collecting duct (CCD) treated with dynasore . Negative_regulation KCNN1 IGFBP1 14508607 1145372 , a novel Cdc25 related phosphatase , *suppresses* Schizosaccharomyces pombe [hsk1] ( cdc7 ) . Negative_regulation KCNQ4 KCNE1 16914890 1602385 The deafness associated Jervell and Lange- Nielsen syndrome ( JLNS ) mutation KCNE1 ( D76N ) impairs KCNQ4-function whereas the Romano-Ward syndrome ( RWS ) mutant ( S74L ) , which shows normal hearing in patients , does not *impair* [KCNQ4] channel function . Negative_regulation KDR ADAMTS1 12716911 1100618 In the present study , we demonstrate that significantly *blocks* [VEGFR2] phosphorylation with consequent suppression of endothelial cell proliferation . Negative_regulation KDR TNF 10753929 682418 In human umbilical vein endothelial cells ( HUVECs ) , *inhibits* the phosphorylation and activation of [KDR] . Negative_regulation KDR TNF 14970118 1209289 In a rat model of hindlimb ischemia , VEGF increased but activation of [KDR/flk-1] was *suppressed* , possibly by , which might impair angiogenesis . Negative_regulation KDR TNF 15555625 1340072 significantly *reduced* protein levels of [VEGFR-2] , VEGFR-3 , and NRP-1 by 59 , 35 , and 22 % , respectively . Negative_regulation KHSRP EPHB2 24026251 2846116 Our results also demonstrate that inhibition of and CK2 *caused* a further increase in the activation of the [p75NTR] proximal promoter induced by ethanol . Negative_regulation KHSRP TNF 8679222 372505 Interestingly , activation of the TNF alpha-p75 receptor with a selective agonist , recombinant ( rTNF alpha-p75 ) , or *inhibition* of the TNF [alpha-p75] receptor with utr-1 , an inhibitory anti-TNF alpha-p75 receptor antibody , had no effect on TNF alpha augmented calcium transients or on myocyte growth . Negative_regulation KIF18A TNF 22025632 2508078 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation KIF2A TNF 22025632 2508083 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation KIF2B TNF 22025632 2508079 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation KIF2C TNF 22025632 2508084 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation KIT ANO1 23576565 2799908 Here , we report that loss of DOG1 expression occurs together with loss of KIT expression in a subset of GIST resistant to KIT inhibitors , and we illustrate the functional *role* of in tumor growth , [KIT] expression , and imatinib response . Negative_regulation KITLG TNF 7680401 211565 In contrast , activation of DNA synthesis by [MGF] was abrogated in the *presence* of ( TNF ; four out of 10 cases ) and interleukin-4 ( IL-4 ; two out of 10 cases ) . Negative_regulation KL TNF 22778214 2645298 *represses* [ß-Klotho] expression and impairs FGF21 action in adipose cells : involvement of JNK1 in the FGF21 pathway . Negative_regulation KL TNF 22778214 2645299 *repressed* [ß-Klotho] expression and impaired FGF21 action in adipocytes . Negative_regulation KLF2 TNF 15988006 1429184 potently *inhibited* [KLF2] expression . Negative_regulation KLF4 TNF 17339326 1726663 Overexpression of [Kruppel-like factor 4] *induces* expression of multiple anti-inflammatory and anti-thrombotic factors including endothelial nitric-oxide synthase and thrombomodulin , whereas knockdown of Kruppellike factor 4 leads to enhancement of alpha induced vascular cell adhesion molecule-1 and tissue factor expression . Negative_regulation KLF4 TP63 20972454 2389527 We find that directly *represses* [KLF4] in normal keratinocytes (KCs) by binding to upstream promoter sites . Negative_regulation KLF9 BMP2 20410205 2274291 KLF13 knockdown attenuated BMP2 and PGR-B and abrogated *mediated* inhibition of [KLF9] expression . Negative_regulation KLK3 FOXA1 18178153 1856277 Furthermore , overexpression *reduces* the androgen induced expression of [prostate-specific antigen (PSA)] in LNCaP cells . Negative_regulation KLK3 ID1 19662653 2224446 The helix-loop-helix *inhibits* [PSA] expression in prostate cancer cells . Negative_regulation KLK3 IL1B 9792142 542522 Our findings reveal that monocyte derived inhibits the proliferation of androgen-responsive prostate tumour cells and *reduces* AR and [PSA] levels . Negative_regulation KLKB1 PLAT 3930349 52304 Factor VIII activity and related antigen , fibrinogen , fibrinopeptide A , antithrombin III , plasminogen , , fast inhibitor of t-PA , alpha 2-antiplasmin , urokinase inhibitors , fragment B beta 15-42 and [kallikrein] *inhibition* were analyzed . Negative_regulation KLKB1 PLAU 1917142 168250 Chymotrypsin , plasmin and [kallikrein] were inhibited to a lesser extent , but , elastase , thrombin and papain were not *inhibited* . Negative_regulation KLKB1 TFPI2 8555184 347347 In addition to its ability to inhibit the amidolytic and proteolytic activities of the factor VIIa-tissue factor complex , strongly *inhibited* the amidolytic activities of human factor XIa , human [plasma kallikrein] , and human plasmin with Ki values of 15 , 25 , and 3 nM , respectively . Negative_regulation KLRC1 HRH1 22304689 2575864 The histamine H1 receptor ( H1R ) agonist 2-pyridylethylamine and H2R agonist dimaprit down-regulated the expression of NKG2D ligands , and activation of H1R and H2R signalling by A23187 and forskolin , respectively , had the same effect , indicating that the histamine induced down-regulation of [NKG2D] ligands is *mediated* by and H2R . Negative_regulation KNTC1 WIF1 20175243 2215649 It has been shown that affects the formation of somites in Xenopus embryos and *inhibits* [rod] production in retinal histogenesis by binding to Wnt4 in mice . Negative_regulation KRAS EPHB2 10978313 751954 Whereas the essential *roles* of and JNK in [Ras] signaling has been established , the contribution of p38 remains unclear . Negative_regulation KRAS EPHB2 11585923 866387 We find that unlike other receptor tyrosine kinases , *induces* a pronounced downregulation of GTP bound [Ras] and consequently of the extracellular signal regulated kinase ( ERK ) mitogen activated protein kinase (MAPK) pathway . Negative_regulation KRAS EPHB2 11874466 918776 Further evidence for differential regulation of RAS and ERK is provided by the observations that TPO , which activates RAS but not protein kinase C , does not activate , and that the inhibitor of SRC kinases PP1 *inhibits* activation of [RAS] but not ERK2 in response to thrombin . Negative_regulation KRAS EPHB2 14660603 1202130 However , when COS-1 cells were transfected with Ras complexed to CD8 , plasma membrane localization of [Ras] was unaffected by AFC , yet EGF stimulated activation was *inhibited* by AFC . Negative_regulation KRAS EPHB2 15070811 1265716 Specific IL-1 receptor antagonism and selective kinase or upstream [Ras] *inhibition* prevented these increases , whereas PKC inhibition did not . Negative_regulation KRAS EPHB2 16978937 1673655 Matrix mineralization by preosteocytic MLO-A5 cells and osteoblastic MC3T3-E1 cells was increased by either PD98059 Mek inhibitor treatment or adenovirus vector mediated dominant negative [Ras] ( Ras ( DN ) ) expression and was *suppressed* by activation by platelet derived growth factor ( PDGF ) treatment or constitutively active Mek1 ( Mek ( CA ) ) expression . Negative_regulation KRAS EPHB2 22142613 2530534 Cellular evaluation of 1b revealed that it alters the subcellular localization of [GFP-KRas] , and also *inhibits* both Ras activation and phosphorylation in Jurkat cells . Negative_regulation KRAS EPHB2 22371971 2561713 Inhibition of calcineurin further reduced the phosphorylation of and AKT ( at thr 308 ) and *inhibited* the activation of [Ras] , but inhibitors of MAPK or PI3K signaling did not affect the circadian rhythm of calcineurin activity . Negative_regulation KRAS EPHB2 22425622 2612650 DGKa knockdown impaired MEK and phosphorylation , but did not *inhibit* [Ras] activation in HCC cells . Negative_regulation KRAS EPHB2 24576830 2929523 In these cell lines , the MEK inhibitor PD0325901 inhibited phosphorylation , but also relieved feedback *inhibition* of [RAS] , resulting in induction of pMEK and a rapid rebound in ERK signaling . Negative_regulation KRAS FAS 9829751 551127 However , in the presence of oncogenic [K-Ras] , survival did not *involve* down-regulation of or FasL expression but did involve members of the Bcl-2 family . Negative_regulation KRAS FHL1 23456229 2781796 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Negative_regulation KRAS MAP2K6 10978313 751969 Moreover , the constitutive p38 activator also *suppressed* [Ras] activity in a p38 dependent manner whereas arsenite , a potent chemical inducer of p38 , inhibited proliferation only in a tumor cell line that required Ras activity . Negative_regulation KRAS MAP2K6 12364324 1019059 GLP1 stimulated activation of Erk is blocked by inhibitors of , but GLP1 does not *induce* the activation of A-Raf , B-Raf , C-Raf , or [Ras] . Negative_regulation KRAS MAP2K6 12411397 1010728 PE and ET-1 do not activate protein kinase B but *stimulate* [Ras] and Erk , and their ability to activate protein synthesis was blocked by inhibition of Ras or and by rapamycin , which inhibits mTOR ( mammalian target of rapamycin ) . Negative_regulation KRAS MAP2K6 22425622 2612656 DGKa knockdown impaired and ERK phosphorylation , but did not *inhibit* [Ras] activation in HCC cells . Negative_regulation KRAS MUC16 17268066 1691600 Expression of [RAS1mRNA] in C. albicans was *inhibited* by . Negative_regulation KRAS PLAU 16826166 1638592 Functional blockade of or inhibition of p70S6 kinase , but not *inhibition* of [Ras/ERK] signaling , suppresses this GM3 induced stimulation of cell proliferation . Negative_regulation KRAS TNF 12526099 1028246 These results indicate that [RAs] attenuate iNOS expression reversibly in TNF stimulated 3T3-L1 adipocytes , and that the induced LPL suppression is not the *result* of NO overproduction . Negative_regulation KRAS TNF 21938476 2532756 With 4-MC pretreatment to hyperglycemic rats the following results were noted : ( i ) Decrease in pancreatic NGF level was blocked , ( ii ) Increase in pancreatic level and the number of TNF-a ( + ) beta cell in the islets were prevented , ( iii ) *Increase* in the number of ß cell synthhesized apoptotic [Ras] effectors that RASSF1 and NORE1 was blocked , ( iv ) While pancreatic lipid peroxidation level decreased , antioxidant molecule glutathione and antioxidant enzymes glutathione peroxidase , catalase and superoxide dismutase activities increased , ( v ) Pancreatic caspase-3 activity and the number of cleaved caspase-3 ( + ) ß cells were decreased . Negative_regulation KRR1 GLP1R 11845326 912443 Over-expression of in transfected INS-1 cells *reduces* the threshold for exendin-4 agonist action , whereas basal [RIP1-Luc] activity increases 2.5-fold in the absence of added agonist . Negative_regulation KRT14 FAS 9343182 458906 Here we show that , as an early event during infection , the adenovirus [E3-10.4K/14.5K] complex selectively *induces* loss of surface expression and blocks Fas induced apoptosis of virus infected cells . Negative_regulation KRT14 TNF 9343182 458909 Further , [10.4K/14.5K] , which was previously shown to protect against TNF cytolysis , does not *induce* a loss of receptor , indicating that this complex mediates more than one function to block host defense mechanisms . Negative_regulation KRT15 TNF 10623468 658052 Expression of [K15] was also *suppressed* by and to a lesser extent by epidermal growth factor (EGF) and keratinocyte growth factor (KGF) . Negative_regulation KRT3 JAG1 17652726 1776211 In contrast , activation *resulted* in decreased [CK3] expression ( P < 0.05 ) , though neither Notch activation nor inhibition affected cell proliferation in the 3D tissue equivalent . Negative_regulation KRT38 AP2A1 7517240 243411 Thus , the *role* of in [keratin] gene expression is quantitative rather than qualitative . Negative_regulation KRT38 AP2M1 7517240 243412 Thus , the *role* of in [keratin] gene expression is quantitative rather than qualitative . Negative_regulation KRT38 HOXC13 11714694 904008 is *involved* in the regulation of human hair [keratin] gene expression . Negative_regulation KRT38 KLF6 12407152 1010182 This study was conducted to investigate the possible involvement of Krüppel-like factor 6 (KLF6) in the corneal regulation of K12 gene expression , in view of the presence of one KLF6 potential binding site in the human K12 promoter and the known *role* of in regulating [keratin] gene expression . Negative_regulation KRT38 KRT6A 17914454 1858479 As predicted for a dominant negative disease , simultaneous expression of both wild-type and mutant *resulted* in defective [keratin] filament formation . Negative_regulation KRT38 PTHLH 8170470 255128 inhibition in HPK1A-AS cells *resulted* in reduced high mol wt [keratin] production , as assessed by immunocytochemistry . Negative_regulation KRT38 TFAP2A 1722450 173350 This paper identifies a new , developmental *role* for transcription factor in the activation of amphibian embryonic epidermal [keratin] gene expression . Negative_regulation KRT38 TFAP2A 1722450 173500 Thus , the study of and its *role* in the regulation of [keratin] gene transcription should enhance our understanding of both amphibian embryonic development and mammalian skin differentiation . Negative_regulation KRT7 FOXA1 20043065 2192775 It was also revealed that FOXA1 siRNA treatment of esophageal cancer cells reduced the mRNA level of both [KRT7] and a stabilizer of epithelial-mesenchymal transition (EMT) regulator LOXL2 , and that both and LOXL2 siRNAs *reduced* invasion and migration of ESCC cells . Negative_regulation KSR2 MAP2K6 22801368 2660156 While constitutive activation of AMPK was sufficient to complement the loss of KSR2 in metabolic signaling and anchorage independent growth , [KSR2] RNAi , *inhibition* , and expression of a KSR2 mutant unable to interact with ERK demonstrated that mitogen activated protein (MAP) kinase signaling is dispensable for the transformed phenotype of these cells . Negative_regulation LAD1 ITGB2 22474478 2578735 Absence of ß2 integrins ( ) *leads* to [leukocyte-adhesion deficiency-1 (LAD1)] , a rare primary immunodeficiency syndrome . Negative_regulation LAMA5 COL17A1 8629821 361120 In one of the nine patients with GABEB , the level was sufficient , but the [laminin-5] level was *reduced* . Negative_regulation LAMB2 COL17A1 8629821 361121 In one of the nine patients with GABEB , the level was sufficient , but the [laminin-5] level was *reduced* . Negative_regulation LAMB3 MICA 17608792 1768536 In strains overexpressing sigma ( E ) , accumulation *leads* to a significant decrease in [LamB] protein and mRNA levels , as well as a reduction in beta-galactosidase activity in a strain carrying a lamB-lacZ translational fusion . Negative_regulation LAMC3 COL17A1 8629821 361122 In one of the nine patients with GABEB , the level was sufficient , but the [laminin-5] level was *reduced* . Negative_regulation LANCL1 EPHB2 16394015 1506063 These results suggest that H. hepaticus induces ERK activation by a pathway dependent upon Tpl-2 and p105 , and that activation of *inhibits* the expression of IL-12 [p40] by inducing c-Fos . Negative_regulation LANCL1 GPNMB 17475886 1738537 overexpression in RAW264.7 cells *caused* a 2-fold reduction in the production of the cytokines IL-6 and [IL-12p40] and the inflammatory mediator NO in response to LPS . Negative_regulation LAP3 CST6 7578223 329135 The new scission conditions have been tested by removing the N-terminal residue from , an *inhibitor* of cysteine [peptidases] ; Negative_regulation LARP6 EGLN3 24477694 2913242 On the other hand , forced expression of *reduced* cell proliferation in [ACHN] . Negative_regulation LBH WNT7A 20606007 2303896 In contrast , [LBH] induction by Wnt/beta-catenin signaling is *inhibited* by , which in limb development signals through a noncanonical pathway involving Lmx1b . Negative_regulation LBH WNT7A 20606007 2303905 Deregulation of LBH in human basal breast cancer appears to be Wnt/beta-catenin dependent , as DKK1 and *inhibit* [LBH] expression in breast tumor cells . Negative_regulation LBP MYLIP 23015294 2689438 overexpression *down-regulated* the [lipopolysaccharide binding protein (LBP)] in 3T3-F442A cells , whereas miR883b-5p blockade had reverse effects . Negative_regulation LBP MYLIP 23015294 2689440 , which is up-regulated by ApN *represses* [LBP] and Toll-like receptor-4 signaling , acting therefore as a major mediator of the antiinflammatory action of ApN . Negative_regulation LBP TGFB1 15114678 1241427 These data were confirmed employing primary human hepatocytes , where also *inhibited* [LBP] protein synthesis . Negative_regulation LCK SELL 8986819 404089 In this study we show that triggering of Jurkat cells using different antibodies or glycomimetics *resulted* in activation of the src-tyrosine kinase [p56lck] ; Negative_regulation LDHA PGC 23650363 2791111 Concomitantly , *reduces* the expression of [LDH A] and one of its regulators , the transcription factor myelocytomatosis oncogene . Negative_regulation LDHB TNF 14586559 1187181 Contrary to this , in PBMC of NHL patients prior to therapy *induced* a significant decrease ( p < 0.05 ) of [LDH-H] isotype activity . Negative_regulation LDLR IL1B 16543490 1549713 These observations demonstrate that *disrupts* cholesterol mediated [LDL receptor] feedback regulation , permitting intracellular accumulation of unmodified LDL and causing foam cell formation . Negative_regulation LDLR KLF9 18056793 1861298 Transient transfection of KLF4 , , and KLF13 *suppressed* [LDLR/luc] , StAR/luc , and CYP11A/luc by 80-90 % ( P < 0.001 ) . Negative_regulation LDLR PCSK9 15118091 1244591 Furthermore , whereas overexpression of *had* no effect on [LDLR] mRNA levels , there was a near absence of LDLR protein in animals overexpressing Pcsk9 . Negative_regulation LDLR PCSK9 15358785 1334161 The LDLR levels are also reduced in stable HepG2 cells overexpressing NARC-1 or its natural mutant S127R , and this reduction is abrogated in the presence of 5 mm ammonium chloride , suggesting that overexpression of *increases* the turnover rate of the [LDLR] . Negative_regulation LDLR PCSK9 15677715 1369868 These results indicate that overexpression of *induces* the degradation of the [LDLR] by a nonproteasomal mechanism in a post-endoplasmic reticulum compartment . Negative_regulation LDLR PCSK9 17242417 1710110 Moreover , inhibition of expression *resulted* in a 2-fold increase in hepatic [LDLR] protein levels . Negative_regulation LDLR PCSK9 17449864 1760967 When infused directly into C57B6 mice , purified human substantially *reduced* hepatic [LDLR] protein levels and resulted in increased plasma LDL cholesterol . Negative_regulation LDLR PCSK9 17493938 1766641 Finally , we show that LDL diminishes PCSK9 binding to [LDLR] in vitro and partially *inhibits* the effects of secreted on LDLR degradation in cell culture . Negative_regulation LDLR PCSK9 17765244 1858236 Our study therefore indicates that *mediated* inhibition of the [LDLR] does not require PCSK9 autocatalytic cleavage or secretion , suggesting that PCSK9 may also function intracellularly . Negative_regulation LDLR PCSK9 18354138 1906274 Combined , these data suggest that exogenously administrated in plasma preferentially *reduces* [LDLR] protein levels in liver at concentrations found in human plasma and that PCSK9 's action on the LDLR is not dependent on catalytic activity in vivo . Negative_regulation LDLR PCSK9 18406350 1907469 We present evidence that recombinant , either injected intravenously into or expressed in the liver of C57BL/6 mice , significantly *reduced* [LDLR] levels in multiple extrahepatic tissues . Negative_regulation LDLR PCSK9 19443683 2096664 In vitro , mAb1 inhibits PCSK9 binding to the LDLR and attenuates *mediated* reduction in [LDLR] protein levels , thereby increasing LDL uptake . Negative_regulation LDLR PCSK9 19489072 2102868 Interestingly , stable expression of or a more active membrane bound form of the protein ( PCSK9-ACE2 ) *resulted* in a marked reduction in CD81 and [LDLR] expression . Negative_regulation LDLR PCSK9 20448210 2275158 The expression of D374Y or WT human increased the serum cholesterol level and *reduced* hepatic [low-density lipoprotein receptor] protein levels in the transgenic mice compared with bacterial artificial chromosome negative controls ; Negative_regulation LDLR PCSK9 21518694 2439594 *reduces* the protein levels of the [LDL receptor] in mouse brain during development and after ischemic stroke . Negative_regulation LDLR PCSK9 22019884 2539870 This antibody , J16 , and its precursor mouse antibody , J10 , potently inhibit PCSK9 binding to the LDLR extracellular domain and *mediated* down-regulation of [LDLR] in vitro . Negative_regulation LDLR PCSK9 22575316 2597988 But statins also activate the expression of , a secreted *inhibitor* of the [LDL receptor] , thereby limiting their beneficial effects . Negative_regulation LDLR PCSK9 22593575 2619802 Similar to in vitro , the increased expression by pioglitazone and/or U0126 did not *result* in decreased [LDLR] expression and function . Negative_regulation LDLR PCSK9 23675525 2785379 Conversely , also *acts* on LRP-1 in the absence of the [LDLR] in CHO-A7 cells , where re-introduction of the LDLR leads to reduced PCSK9 mediated degradation of LRP-1 . Negative_regulation LDLR PCSK9 24252255 2904081 Although the antibody does not inhibit binding of PCSK9 to epidermal growth factor-like repeat A , it partially reverses *induced* reduction of the [LDLR] and LDL cholesterol uptake in a cellular assay . Negative_regulation LDLR PCSK9 24296664 2899046 Despite LDLR dependent PCSK9 uptake , cell surface [LDLR] levels in SV-589 fibroblasts were only modestly *reduced* by wild-type , even at high nonphysiological concentrations ( 20 µg/ml ) . Negative_regulation LDLR TNF 9840652 552790 Recombinant soluble receptors *inhibited* the TNF induced stimulation of [low-density lipoprotein receptor] in a concentration dependent manner . Negative_regulation LEF1 AXIN2 10318824 611915 We also examined the ability of each mutant to *inhibit* [lymphoid enhancer factor-1 (Lef-1)] reporter activity in a cell line expressing high levels of beta-catenin . Negative_regulation LEF1 AXIN2 10428961 633432 To understand the mechanism by which Dvl acts through GSK to regulate LEF-1 , we investigated the *roles* of and Frat1 in Wnt mediated activation of [LEF-1] in mammalian cells . Negative_regulation LEFTY1 MAP2K6 23407711 2787119 We also found that a inhibitor dramatically *enhanced* [Lefty] expression in human pancreatic cancers with mutated ras , whereas Lefty B CpG methylation was not decreased . Negative_regulation LEFTY2 MAP2K6 23407711 2787112 We also found that a inhibitor dramatically *enhanced* [Lefty] expression in human pancreatic cancers with mutated ras , whereas Lefty B CpG methylation was not decreased . Negative_regulation LEO1 ARSA 6711391 37377 These studies suggest that regulates PAF availability unrelated to its effect on cyclooxygenase and that MC membrane products directly *inhibit* [PAF] activity from rat PLC . Negative_regulation LEO1 ARSA 8430224 212743 Since acetylsalicylic acid (ASA) is an accepted therapeutic alternative in these patients , we sought to determine if would *attenuate* endothelial cell [PAF] production resulting from ACA exposure . Negative_regulation LEO1 CD14 7541418 310479 The soluble form of ( sCD14 ) , when added to MO stimulated with LBP-LPS complexes , *inhibited* the synthesis of [PAF] possibly by competing with mCD14 . Negative_regulation LEO1 IL1B 1519663 196906 Stimulation of isolated mouse alveolar macrophages with recombinant murine or IL-1 alpha *resulted* in rapid , dose dependent , and cell concentration dependent increases in [PAF] secretion . Negative_regulation LEO1 TNF 9403541 469612 Furthermore , inhibiting [PAF] production with AACOCF3 , or manoalide , also *inhibited* LPS induced Mphi mRNA expression . Negative_regulation LEP FOXO1 19049975 2029656 *inhibits* [leptin] regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1 . Negative_regulation LEP IL1B 9458919 484656 To investigate the *role* of and IL-6 in [leptin] expression during inflammation , we used IL-1 beta-deficient ( -/- ) and IL-6 -/- mice . Negative_regulation LEP TNF 10490793 645628 TNF-alpha at concentrations of 0.024 , 0.24 , 2.4 and 24 ng/ml did not affect leptin secretion over 24 h . at concentrations of 0.24 to 24 ng/ml significantly *inhibited* [leptin] secretion over 96 h by 19-60 % . Negative_regulation LEP TNF 10526261 654179 The aim of this study was to characterize the *role* of and transforming growth factor (TGF)-beta1 in depot-specific secretion of [leptin] from cultured human adipocytes . Negative_regulation LEP TNF 10687854 669926 *blocked* [leptin] synthesis during differentiation . Negative_regulation LEP TNF 10687854 669927 In contrast , ( 4-8-h treatment ) *resulted* in a 4-fold increase in [leptin] release . Negative_regulation LEP TNF 10687854 669929 We conclude that stimulates the release of preformed leptin from human mature adipocytes and existing differentiated preadipocytes , which may contribute to obesity/infection linked hyperleptinemia , and that TNF-alpha *inhibits* [leptin] synthesis via inhibition of preadipocyte differentiation and induction of adipocyte dedifferentiation . Negative_regulation LEP TNF 10690850 670424 *inhibits* [leptin] production in subcutaneous and omental adipocytes from morbidly obese humans . Negative_regulation LEP TNF 10690850 670425 [Leptin] release from sc adipocytes was *inhibited* 17.7 +/- 5.2 % ( P < 0.01 ) , 21.6 +/- 4.3 % ( P < 0.005 ) , and 37.1 +/- 7.2 % ( P < 0.05 ) by 1 , 10 , and 100 ng/mL , respectively , after 48 h in culture . Negative_regulation LEP TNF 10690850 670428 In omental adipocytes *inhibited* [leptin] release 21.0 +/- 9.6 % and 40.8 +/- 6.3 % at 10 and 100 ng/mL by 48 h ( P < 0.05 ) . Negative_regulation LEP TNF 10690850 670429 Anti-TNFalpha antibody completely blocked *inhibition* of [leptin] release . Negative_regulation LEP TNF 10793089 689528 We examine whether the decrease in [leptin] induced by starvation increases susceptibility to lipopolysaccharide (LPS)- and *induced* lethality . Negative_regulation LEP TNF 11564702 863275 The protease inhibitors , protease inhibitor 1 and Immunex compound 2 , could *inhibit* the production of [leptin] binding protein , indicating that the enzyme responsible for leptin binding protein cleavage belongs to the metalloprotease family . Negative_regulation LEP TNF 9514868 492948 Moreover , human ( h-TNF-alpha ) also *inhibited* [human-leptin] ( h-leptin ) secretion by cultured human adipocytes collected from the subcutaneous fat of pregnant women . Negative_regulation LEP TNF 9514868 492949 These results suggest that , which is secreted by adipocytes , *inhibits* [m-leptin] secretion through mTNF-RI and suggest the presence of an autocrine or paracrine regulation of leptin secretion in human and mouse adipose tissue in vivo . Negative_regulation LEP TNF 9564834 500793 To examine the *role* of in mediating [leptin] secretion during an immunological challenge , we studied the effects of lipopolysaccharide (LPS) and TNF alpha on leptin secretion in endotoxin-sensitive C3H/HeOuJ ( OuJ ) mice , endotoxin-insensitive C3H/HeJ ( HeJ ) mice , and primary adipocytes cultured from both . Negative_regulation LEPR TNF 23070544 2703394 We investigated a possible *role* of , a key early mediator of inflammation , in regulating the expression and trafficking of the long-isoform [leptin receptor] ( LEPRb ) , the primary mediator of leptin signaling , in cultured cells . Negative_regulation LGALS1 MAP2K6 16157583 1475817 Pharmacologic inhibitors of protein kinase C , Ras , and , but not phosphoinositide 3-kinase , *block* [ST6Gal-I] down-regulation , integrin hyposialylation , and fibronectin binding . Negative_regulation LGALS1 TFPI2 6603232 29524 levels were generally elevated , [hPL] levels were *reduced* and SP1 levels were within the usual ranges . Negative_regulation LGALS3 FAS 17635791 1770635 Specific targeting of evasion mechanisms displayed in T. cruzi infection , as in vivo blockade or [Gal-3] expression *inhibition* , allowed us to modulate B-cell responses enhancing the anti-parasite humoral immune response . Negative_regulation LGALS3 TNF 11981338 935055 Downregulation of [galectin-3] in the intestinal epithelium of Crohn 's disease patients may be a *consequence* of enhanced production by inflammatory cells , thereby contributing to the pathophysiology of the disease . Negative_regulation LGALS4 NR2F1 9171235 433346 Furthermore , overexpression of N-CoR or SMRT potentiates the silencing activity of COUP-TFI and can relieve the *mediated* squelching of [Gal4-COUP-TFI] activity . Negative_regulation LGALS7B LGALS4 10890898 710572 Interestingly , overexpression of restores promoter occupancy , *activates* [GAL7] expression , and rescues growth on the otherwise toxic galactose substrate . Negative_regulation LGMN CST6 11501761 847214 The plant form of [legumain] was much more weakly *inhibited* by egg-white than was the mammalian form . Negative_regulation LGMN CST6 15044380 1237391 Absence of *causes* unrestricted activity of its target protease [legumain] in hair follicles and epidermis , which is the exact location where cystatin M/E is normally expressed . Negative_regulation LGMN CST6 16150465 1507397 inhibition significantly *increased* the enzymatic activities of cathepsins B and L and [legumain] while reducing cysteine protease inhibitor activity both in the media and intracellularly . Negative_regulation LGMN CST6 23686917 2811183 In this study , we determined expression of [legumain (LGMN)] , a cathepsinmember , and its *inhibitor* , , at the maternal-fetal interface in pigs . Negative_regulation LHB EPHB2 20685880 2322786 Dusp1 overexpression abolishes sustained activation and *inhibits* [Lhb] promoter activity induced by high amplitude pulses . Negative_regulation LHB FOXO1 22865884 2677413 We also showed that *repressed* basal transcription and gonadotropin releasing hormone (GnRH) induction of both the murine and human [LHB] genes in LßT2 cells , suggesting that FOXO1 regulation of LHB transcription may be conserved between rodents and humans . Negative_regulation LHB FOXO1 22865884 2677418 Additionally , *blocked* induction of the [Lhb] promoter with overexpressed SF1 , PTX1 , and EGR1 , indicating that FOXO1 repression occurs via these transcription factors but not through regulation of their promoters . Negative_regulation LHB FOXO1 22865884 2677419 In summary , we demonstrate that FOXO1 phosphorylation and cellular localization is regulated by insulin signaling in gonadotropes and that *inhibits* [Lhb] transcription . Negative_regulation LHB FOXO1 24065703 2857760 Recently , we reported that insulin regulates FOXO1 phosphorylation and cellular localization in pituitary gonadotropes and that overexpression *inhibits* [Lhb] transcription . Negative_regulation LHCGR TNF 9916010 587448 significantly *inhibited* hCG/PRL induced StAR and [LHR] mRNA expression at 1 and 3 h post-TNFalpha . Negative_regulation LHCGR TNF 9916010 587452 It is suggested that the luteolytic effect of may be *mediated* by its direct inhibition on StAR expression or by an indirect decrease in [LHR] expression . Negative_regulation LIF MAP2K6 22463982 2612927 Naïve pluripotent stem cell lines are distinguished from primed cells by self-renewal in response to [LIF] signaling and *inhibition* ( LIF/2i conditions ) and two active X chromosomes in female cells . Negative_regulation LIF TNF 17443676 1772111 Despite the increase of gp130 , *caused* a significant reduction in the cell binding and endocytosis of [leukemia inhibitory factor (LIF)] , another proinflammatory cytokine that binds to the gp130 co-receptor and its unique gp190 receptor . Negative_regulation LIF TNF 8666813 369117 In addition , to assess the *role* of in the induction of [LIF] in vivo , seven baboons were studied that had either received a bolus injection of recombinant human TNF-alpha ( 100 micrograms/kg , n=3 ) , or to whom 15 mg/kg of an anti-TNF mAB before lethal E. coli challenge was administered ( n=4 ) . Negative_regulation LIN37 EPHB2 23154983 2699980 Furthermore , during vulval induction , the downstream kinase is also *required* for LIN-45 protein degradation in a negative feedback loop , resulting in degradation of [LIN-45] where ERK is highly active . Negative_regulation LIN52 EPHB2 23154983 2699977 Furthermore , during vulval induction , the downstream kinase is also *required* for LIN-45 protein degradation in a negative feedback loop , resulting in degradation of [LIN-45] where ERK is highly active . Negative_regulation LIN54 EPHB2 23154983 2699978 Furthermore , during vulval induction , the downstream kinase is also *required* for LIN-45 protein degradation in a negative feedback loop , resulting in degradation of [LIN-45] where ERK is highly active . Negative_regulation LIN9 EPHB2 23154983 2699979 Furthermore , during vulval induction , the downstream kinase is also *required* for LIN-45 protein degradation in a negative feedback loop , resulting in degradation of [LIN-45] where ERK is highly active . Negative_regulation LIPE TNF 17272828 1733236 Western blot analysis demonstrated that although TNF-alpha per se reduced mainly PLIN protein expression , in the presence of WP *resulted* in a pronounced combined reduction of both [hormone-sensitive lipase (HSL)] and PLIN protein . Negative_regulation LIPE TNF 20628900 2310249 [HSL] activity was also *suppressed* by . Negative_regulation LIPE TNF 20628900 2310251 In the *presence* of , Met , Cys and CysH suppressed the [HSL] activity . Negative_regulation LIPE TNF 9568706 501349 BRL 49653 partially blocked the *mediated* reduction in protein levels of [hormone-sensitive lipase] and perilipin A , two proteins involved in adipocyte lipolysis . Negative_regulation LIPG ANGPTL3 17110602 1686143 In vitro , *inhibited* the phospholipase activity of [endothelial lipase (EL)] , which hydrolyzes HDL-PL and hence decreases plasma HDL levels , through a putative heparin binding site in the N-terminal domain of ANGPTL3 . Negative_regulation LIPG HSPB3 20031622 2176957 The proprotein convertase subtilisin/kexin type 5 ( PCSK5 ) gene product is known to directly inactivate endothelial lipase and indirectly cleave and activate angiopoetin-like , a natural *inhibitor* of [endothelial lipase] . Negative_regulation LMNB1 IL1B 16830232 1586792 Based on these findings , we propose that mediated inhibition of PP4 activity might *result* in the retention of [lamin-B] in its phosphorylated state , which is a requisite for its degradation by caspases leading to the apoptotic demise of the beta cell ( Veluthakal et al. : Am J Physiol Cell Physiol 287 : C1152-C1162 , 2004 ) . Negative_regulation LMNB2 IL1B 16830232 1586794 Based on these findings , we propose that mediated inhibition of PP4 activity might *result* in the retention of [lamin-B] in its phosphorylated state , which is a requisite for its degradation by caspases leading to the apoptotic demise of the beta cell ( Veluthakal et al. : Am J Physiol Cell Physiol 287 : C1152-C1162 , 2004 ) . Negative_regulation LNPEP TNF 14751233 1205215 The hydroxamic acid based metalloprotease inhibitors GM6001 and ONO-4817 as well as the *reduced* [P-LAP] release , while tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 , which are matrix metalloproteinase inhibitors , had no effect on P-LAP release in Chinese hamster ovary ( CHO ) cells stably overexpressing P-LAP , thus indicating possible involvement of ADAM ( a disintegrin and metalloproteinase ) members in P-LAP shedding . Negative_regulation LOX ALOX5 21824498 2505505 Previous studies have shown that human prostate cancer cells constitutively generate <5-lipoxygenase (5-LOX)> metabolites from arachidonic acid , and *inhibition* of [5-LOX] blocks production of 5-LOX metabolites and triggers apoptosis in prostate cancer cells . Negative_regulation LOX ALOX5 24295787 2894002 Novel di-tertiary-butyl phenylhydrazones as dual inhibitors : synthesis , [COX/LOX] *inhibition* , molecular modeling , and insights into their cytotoxicities . Negative_regulation LOX CTGF 21215756 2397021 Inhibition of by siRNA transfections completely inhibited AngII *induced* [LOX] expression . Negative_regulation LOX IL1B 19359664 2094506 Treatment with the LOX inhibitor beta-aminopropionitrile resulted in enhanced progression of CA. Expression of procollagen type I , III , and [LOX] was *inhibited* by in cultured rat aortic smooth muscle cells ( RASMCs ) in vitro . Negative_regulation LOX PTGER2 9779823 540434 Role of receptors and cAMP in prostaglandin E2 *regulated* expression of type I collagen alpha1 , [lysyl oxidase] , and cyclooxygenase-1 genes in human embryo lung fibroblasts . Negative_regulation LOX TNF 15138266 1267414 The data together demonstrate that does not inhibit collagen synthesis but does *inhibit* the expression and activity of [lysyl oxidase] in osteoblasts , thereby contributing to perturbed collagen cross linking and accumulation . Negative_regulation LOX TNF 17673218 1858075 In transfection assays , *reduced* [LOX] transcriptional activity to a similar extent than LOX mRNA . Negative_regulation LOX TNF 17673218 1858076 Moreover , while TNFR associated factor-2 (TRAF-2) did not mediate signalling events leading to LOX inhibition , PKC inhibitors counteracted the *induced* decrease of [LOX] mRNA levels . Negative_regulation LOX TNF 17981747 1845622 Interestingly , in vivo studies reveal that *causes* a down-regulation of vascular [LOX] expression . Negative_regulation LPA CAPN8 20420580 2246730 Interestingly , LPA induced down-regulation of MAG was significantly inhibited by inhibitors ( calpain inhibitor X , E-64 and E-64d ) and [LPA] markedly *induced* calpain activation in the DR . Negative_regulation LPA CLU 15961700 1446022 In monkeys , oral D- [ 113-122 ] rapidly *reduced* [lipoprotein lipid hydroperoxides (LOOH)] and improved HDL inflammatory properties . Negative_regulation LPA EPHB2 10688043 669953 Inhibition of EGF- and [LPA-] *induced* activation with the EGF receptor inhibitor , AG1478 , or the MEK inhibitor , PD98059 , attenuated their proliferative effects . Negative_regulation LPA EPHB2 15494214 1354865 These studies indicate a direct involvement of ERK in the alpha ( 1 ) -adrenergic activation of NHE1 and a significant *role* for both and RhoA in [LPA] stimulation of NHE1 in CCL39 fibroblasts . Negative_regulation LPA EPHB2 21209852 2359315 In addition , [LPA] *induced* PAK1 activation while activation and cell migration were inhibited by ectopic expression of an inactive mutant form of PAK1 in MDA-MB-231 cells . Negative_regulation LPA G0S2 23951308 2831721 Hepatic overexpression *resulted* in an increase in plasma Low-density lipoprotein (LDL)/Very-Low-density ( VLDL ) [lipoprotein] cholesterol level . Negative_regulation LPA GLP1R 22237690 2564106 Pharmacological augmentation of signalling by dipeptidyl peptidase 4 (DPP-4) inhibition *reduced* intestinal [lipoprotein] secretion in experimental studies , suggesting that DPP-4 inhibitors may ameliorate dyslipidaemia and thus reduce cardiovascular risk in patients with type 2 diabetes . Negative_regulation LPA PCSK9 23115612 2695871 The *role* of in the regulation of circulating low density [lipoprotein-cholesterol] ( LDL-c ) levels is ascribed to binding of circulating PCSK9 to the LDL receptor (LDLR) and subsequent lysosomal degradation of LDLR . Negative_regulation LPA PCSK9 24509273 2928468 Inhibition of with evolocumab *resulted* in significant dose related reductions in [Lp(a)] . Negative_regulation LPA PLAT 8857956 388371 In experiments using anti-actin antibodies added in excess to cultured ECs , binding of plasminogen was inhibited by 45 % , binding was *inhibited* by 46 % and [Lp(a)] binding was reduced by 56 % , confirming actin as a binding site for these various ligands whilst attesting to the presence of other EC receptors for these proteins . Negative_regulation LPA RGS2 18979070 2015159 In SKOV-3 ovarian cancer cells , but not RGS6 or RGS19/GAIP , *inhibited* [LPA] stimulated inositol phosphate production . Negative_regulation LPA TNF 8387950 218080 Comparison of the kinetics of specific low-density lipoprotein binding in the unstimulated cells and in the tumor necrosis factor stimulated cells indicated that tumor necrosis factor caused a 30 % increase in maximum velocity with no significant change in Michaelis constant , suggesting that *increases* the number of low-density [lipoprotein] receptors on the cells rather than changing binding affinity . Negative_regulation LPIN1 IL1B 18940942 1994809 In 3T3-L1 adipocytes , TNF-alpha , , and IFN-gamma , but not LPS or IL-6 , *caused* a decrease in [lipin-1] mRNA levels . Negative_regulation LPIN1 IL1B 18940942 1994812 Importantly , the LPS induced decrease in lipin-1 mRNA levels was significantly but not totally blunted in TNF-alpha/IL-1 receptor-null mice compared with controls , suggesting key *roles* for and other cytokines in mediating LPS induced repression of [lipin-1] . Negative_regulation LPIN1 PGC 21549711 2435370 Consistent with these data , 3-fold overexpression of in intact myocardium of transgenic mice *increased* cardiac [lipin 1] and ERRa/? expression . Negative_regulation LPIN1 TNF 18940942 1994807 In 3T3-L1 adipocytes , , IL-1beta , and IFN-gamma , but not LPS or IL-6 , *caused* a decrease in [lipin-1] mRNA levels . Negative_regulation LPIN1 TNF 18940942 1994811 Importantly , the LPS induced decrease in lipin-1 mRNA levels was significantly but not totally blunted in TNF-alpha/IL-1 receptor-null mice compared with controls , suggesting key *roles* for and other cytokines in mediating LPS induced repression of [lipin-1] . Negative_regulation LPIN1 TNF 19281795 2055698 Quantitative PCR studies showed that *suppressed* both [lipin-1A] and -1B isoform expression in time- and dose dependent manners in mature 3T3-L1 adpocytes . Negative_regulation LPIN1 TNF 19281795 2055699 These results suggest that could be *involved* in obesity induced [lipin-1] suppression in adipocytes and Jak2 may play an important role in the mechanism . Negative_regulation LPL IL1B 1572904 187239 also depressed adipoconversion , *inhibited* markedly [LPL] activity , and partially reduced GPDH activity . Negative_regulation LPL IL1B 8065547 269073 Moreover , exogenous partially *restored* NPY 's stimulatory effect on monocyte depleted [LPL] DNA synthesis . Negative_regulation LPL TNF 11681809 873922 and IL-6 *inhibit* [lipoprotein lipase] , and TNF-alpha additionally stimulates hormone-sensitive lipase and induces uncoupling protein expression . Negative_regulation LPL TNF 12526099 1028243 also *suppressed* the [lipoprotein lipase (LPL)] activity of 3T3-L1 adipocytes . Negative_regulation LPL TNF 12526099 1028248 These results indicate that RAs attenuate iNOS expression reversibly in TNF stimulated 3T3-L1 adipocytes , and that the *induced* [LPL] suppression is not the result of NO overproduction . Negative_regulation LPL TNF 1709937 158076 Human recombinant , a potent *inhibitor* of [LPL] gene transcription , had no effect on adipocyte apoE mRNA levels . Negative_regulation LPL TNF 17786283 1790888 Scopoletin also partially reversed *induced* suppression of [LPL] activity . Negative_regulation LPL TNF 20628900 2310244 [LPL] activity was *suppressed* by . Negative_regulation LPL TNF 2168471 140316 Pertussis toxin also significantly reduced *induced* inhibition of [lipoprotein lipase] activity in 3T3-L1 adipocytes and TNF blockade of 3T3-L1 preadipocyte differentiation . Negative_regulation LPL TNF 2703526 108880 These results indicate that the TNF induced increase in circulating lipid levels can occur in the absence of a *induced* inhibition of adipose tissue [lipoprotein lipase] activity . Negative_regulation LPL TNF 2840563 95225 *inhibits* [lipoprotein lipase] activity in cultured myocytes and in the Langendorff rat heart after 3 h perfusion with TNF of glucocorticoid pretreated rats . Negative_regulation LPL TNF 3147796 102796 The hyperlipidemia that accompanies this infection may be mediated by the *inhibition* of [lipoprotein lipase] activity . Negative_regulation LPL TNF 3235920 103554 Since LPS stimulates macrophage production of cachectin/tumor necrosis factor (TNF) , a potent inhibitor of LPL production by the 3T3-L1 adipocyte-like cell line , it was determined whether *reduces* macrophage [LPL] levels . Negative_regulation LPL TNF 3261386 96049 Recombinant human necrosis factor *diminished* both [LPL] activity and LPL mRNA levels . Negative_regulation LPL TNF 3411249 96381 Recombinant human does not *inhibit* [lipoprotein lipase] in primary cultures of isolated human adipocytes . Negative_regulation LPL TNF 3411249 96382 Previous studies have demonstrated that necrosis factor (TNF) *inhibits* [lipoprotein lipase (LPL)] activity in cultures of 3T3-L1 cells . Negative_regulation LPL TNF 3411249 96383 To determine whether also *inhibits* [LPL] in human adipocytes , primary cultures of isolated human adipocytes were exposed to a spectrum of concentrations of recombinant human TNF . Negative_regulation LPL TNF 3411249 96384 In contrast , the same in the same concentrations progressively *inhibited* [LPL] activity and immunoreactive mass in 3T3-L1 cells . Negative_regulation LPL TNF 3597377 75571 Thus , *suppresses* [lipoprotein lipase] synthesis in adipocytes , but not in other tissues , and has some as yet undefined effect on lipoprotein lipase turnover in extrahepatic tissues , which results in increased transport of active lipase through plasma to the liver . Negative_regulation LPL TNF 7706477 297780 To elucidate further the transcriptional mechanism of *inhibition* of [LPL] gene transcription , transfection analysis was used to locate the site ( s ) of the LPL promoter that imparts the TNF alpha response . Negative_regulation LPL TNF 7948751 277309 Western blot analysis of cell extracts showed that *caused* a greater decrease in [LPL] protein production than D-factor.2+ with TNF , may contribute to the manifestations of cachexia . Negative_regulation LPL TNF 8732780 374132 While antioxidants accentuated the inhibition of LPL by TNF alpha , addition of H2O2 significantly attenuated *induced* [LPL] inhibition . Negative_regulation LPL TNF 9278582 451396 is expressed at higher levels in muscle cells of insulin-resistant subjects , and TNF may *inhibit* [LPL] expression . Negative_regulation LPL TNF 9644096 514525 also *reduces* [lipoprotein lipase] activity in white adipocytes , stimulates hepatic lipolysis , and increases plasminogen activator inhibitor-1 content in adipocytes . Negative_regulation LPO HBEGF 17337106 1720133 These results indicate that *attenuate* the [LPO] and alteration of antioxidant and membrane bound enzymes in Cd exposed rats , which suggest that DTS protects the brain function from toxic effects of Cd . Negative_regulation LPO TF 708686 7998 These observations are consistent with the concept that can *block* the [lactoperoxidase] catalyzed iodination of this membrane protein by specifically associating with it . Negative_regulation LRP1 CTGF 15469966 1342394 induced tryrosine phosphorylation of the cytoplasmic domain of the low-density lipoprotein receptor associated protein ( LRP ) in fibroblasts , and the LRP-antagonist , receptor associated protein (RAP) *inhibited* CTGF induced tryrosine phosphorylation of [LRP] . Negative_regulation LRP1 PLAT 16489109 1589212 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of and *inhibit* the tPA mediated interaction between [LRP] and alphavbeta3 . Negative_regulation LRP1 PLAT 18037995 1832676 In murine renal interstitium after obstructive injury , and alpha-SMA colocalized with LRP-1 , and tPA deficiency *reduced* [LRP-1/beta1] integrin interaction and myofibroblast activation . Negative_regulation LRP1 PLAU 16459332 1540764 As reported previously for PAI-1 , inhibition of by PAI-2 significantly *increased* the affinity of the complex for [LRP] ( K ( D ) of 36 nm for uPA-PAI-2 versus 200 nm for uPA ) . Negative_regulation LRP1 TNF 9182980 436375 In transfected cells , the endogenous production of *reduced* [LRP] gene expression ( both messenger RNA and protein ) and increased MRP gene expression ( both messenger RNA and protein ) , regardless of cell type . Negative_regulation LRP10 CTGF 15469966 1342391 induced tryrosine phosphorylation of the cytoplasmic domain of the low-density lipoprotein receptor associated protein ( LRP ) in fibroblasts , and the LRP-antagonist , receptor associated protein (RAP) *inhibited* CTGF induced tryrosine phosphorylation of [LRP] . Negative_regulation LRP10 PLAT 16489109 1589209 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of and *inhibit* the tPA mediated interaction between [LRP] and alphavbeta3 . Negative_regulation LRP10 PLAU 16459332 1540761 As reported previously for PAI-1 , inhibition of by PAI-2 significantly *increased* the affinity of the complex for [LRP] ( K ( D ) of 36 nm for uPA-PAI-2 versus 200 nm for uPA ) . Negative_regulation LRP10 TNF 9182980 436372 In transfected cells , the endogenous production of *reduced* [LRP] gene expression ( both messenger RNA and protein ) and increased MRP gene expression ( both messenger RNA and protein ) , regardless of cell type . Negative_regulation LRP11 CTGF 15469966 1342392 induced tryrosine phosphorylation of the cytoplasmic domain of the low-density lipoprotein receptor associated protein ( LRP ) in fibroblasts , and the LRP-antagonist , receptor associated protein (RAP) *inhibited* CTGF induced tryrosine phosphorylation of [LRP] . Negative_regulation LRP11 PLAT 16489109 1589210 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of and *inhibit* the tPA mediated interaction between [LRP] and alphavbeta3 . Negative_regulation LRP11 PLAU 16459332 1540762 As reported previously for PAI-1 , inhibition of by PAI-2 significantly *increased* the affinity of the complex for [LRP] ( K ( D ) of 36 nm for uPA-PAI-2 versus 200 nm for uPA ) . Negative_regulation LRP11 TNF 9182980 436373 In transfected cells , the endogenous production of *reduced* [LRP] gene expression ( both messenger RNA and protein ) and increased MRP gene expression ( both messenger RNA and protein ) , regardless of cell type . Negative_regulation LRP12 CTGF 15469966 1342393 induced tryrosine phosphorylation of the cytoplasmic domain of the low-density lipoprotein receptor associated protein ( LRP ) in fibroblasts , and the LRP-antagonist , receptor associated protein (RAP) *inhibited* CTGF induced tryrosine phosphorylation of [LRP] . Negative_regulation LRP12 PLAT 16489109 1589211 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of and *inhibit* the tPA mediated interaction between [LRP] and alphavbeta3 . Negative_regulation LRP12 PLAU 16459332 1540763 As reported previously for PAI-1 , inhibition of by PAI-2 significantly *increased* the affinity of the complex for [LRP] ( K ( D ) of 36 nm for uPA-PAI-2 versus 200 nm for uPA ) . Negative_regulation LRP12 TNF 9182980 436374 In transfected cells , the endogenous production of *reduced* [LRP] gene expression ( both messenger RNA and protein ) and increased MRP gene expression ( both messenger RNA and protein ) , regardless of cell type . Negative_regulation LRP2 CLU 10670527 666640 The present data also reveal that after efferent duct ligation , there are circulating factors that inhibit expression in a region-specific manner ( corpus and cauda ) and that *inhibit* [LRP-2] expression along the entire epididymis and that these are derived from the testis . Negative_regulation LRP2 CTGF 15469966 1342395 induced tryrosine phosphorylation of the cytoplasmic domain of the low-density lipoprotein receptor associated protein ( LRP ) in fibroblasts , and the LRP-antagonist , receptor associated protein (RAP) *inhibited* CTGF induced tryrosine phosphorylation of [LRP] . Negative_regulation LRP2 EPHB2 18927221 2028687 The AT(1A)R mediated decrease in [megalin] expression was partially *prevented* by inhibitors . Negative_regulation LRP2 PLAT 16489109 1589213 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of and *inhibit* the tPA mediated interaction between [LRP] and alphavbeta3 . Negative_regulation LRP2 PLAU 16459332 1540765 As reported previously for PAI-1 , inhibition of by PAI-2 significantly *increased* the affinity of the complex for [LRP] ( K ( D ) of 36 nm for uPA-PAI-2 versus 200 nm for uPA ) . Negative_regulation LRP2 TNF 21371423 2411528 MEK1 inhibitor PD98059 competed partially but significantly *mediated* downregulation of [megalin] mRNA expression . Negative_regulation LRP2 TNF 9182980 436376 In transfected cells , the endogenous production of *reduced* [LRP] gene expression ( both messenger RNA and protein ) and increased MRP gene expression ( both messenger RNA and protein ) , regardless of cell type . Negative_regulation LRP3 CTGF 15469966 1342396 induced tryrosine phosphorylation of the cytoplasmic domain of the low-density lipoprotein receptor associated protein ( LRP ) in fibroblasts , and the LRP-antagonist , receptor associated protein (RAP) *inhibited* CTGF induced tryrosine phosphorylation of [LRP] . Negative_regulation LRP3 PLAT 16489109 1589214 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of and *inhibit* the tPA mediated interaction between [LRP] and alphavbeta3 . Negative_regulation LRP3 PLAU 16459332 1540766 As reported previously for PAI-1 , inhibition of by PAI-2 significantly *increased* the affinity of the complex for [LRP] ( K ( D ) of 36 nm for uPA-PAI-2 versus 200 nm for uPA ) . Negative_regulation LRP3 TNF 9182980 436377 In transfected cells , the endogenous production of *reduced* [LRP] gene expression ( both messenger RNA and protein ) and increased MRP gene expression ( both messenger RNA and protein ) , regardless of cell type . Negative_regulation LRP4 CTGF 15469966 1342397 induced tryrosine phosphorylation of the cytoplasmic domain of the low-density lipoprotein receptor associated protein ( LRP ) in fibroblasts , and the LRP-antagonist , receptor associated protein (RAP) *inhibited* CTGF induced tryrosine phosphorylation of [LRP] . Negative_regulation LRP4 PLAT 16489109 1589215 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of and *inhibit* the tPA mediated interaction between [LRP] and alphavbeta3 . Negative_regulation LRP4 PLAU 16459332 1540767 As reported previously for PAI-1 , inhibition of by PAI-2 significantly *increased* the affinity of the complex for [LRP] ( K ( D ) of 36 nm for uPA-PAI-2 versus 200 nm for uPA ) . Negative_regulation LRP4 TNF 9182980 436378 In transfected cells , the endogenous production of *reduced* [LRP] gene expression ( both messenger RNA and protein ) and increased MRP gene expression ( both messenger RNA and protein ) , regardless of cell type . Negative_regulation LRP5 CTGF 15469966 1342398 induced tryrosine phosphorylation of the cytoplasmic domain of the low-density lipoprotein receptor associated protein ( LRP ) in fibroblasts , and the LRP-antagonist , receptor associated protein (RAP) *inhibited* CTGF induced tryrosine phosphorylation of [LRP] . Negative_regulation LRP5 PLAT 16489109 1589216 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of and *inhibit* the tPA mediated interaction between [LRP] and alphavbeta3 . Negative_regulation LRP5 PLAU 16459332 1540768 As reported previously for PAI-1 , inhibition of by PAI-2 significantly *increased* the affinity of the complex for [LRP] ( K ( D ) of 36 nm for uPA-PAI-2 versus 200 nm for uPA ) . Negative_regulation LRP5 TNF 9182980 436379 In transfected cells , the endogenous production of *reduced* [LRP] gene expression ( both messenger RNA and protein ) and increased MRP gene expression ( both messenger RNA and protein ) , regardless of cell type . Negative_regulation LRP6 CTGF 15469966 1342399 induced tryrosine phosphorylation of the cytoplasmic domain of the low-density lipoprotein receptor associated protein ( LRP ) in fibroblasts , and the LRP-antagonist , receptor associated protein (RAP) *inhibited* CTGF induced tryrosine phosphorylation of [LRP] . Negative_regulation LRP6 PLAT 16489109 1589217 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of and *inhibit* the tPA mediated interaction between [LRP] and alphavbeta3 . Negative_regulation LRP6 PLAU 16459332 1540769 As reported previously for PAI-1 , inhibition of by PAI-2 significantly *increased* the affinity of the complex for [LRP] ( K ( D ) of 36 nm for uPA-PAI-2 versus 200 nm for uPA ) . Negative_regulation LRP6 TNF 9182980 436380 In transfected cells , the endogenous production of *reduced* [LRP] gene expression ( both messenger RNA and protein ) and increased MRP gene expression ( both messenger RNA and protein ) , regardless of cell type . Negative_regulation LRP8 CTGF 15469966 1342400 induced tryrosine phosphorylation of the cytoplasmic domain of the low-density lipoprotein receptor associated protein ( LRP ) in fibroblasts , and the LRP-antagonist , receptor associated protein (RAP) *inhibited* CTGF induced tryrosine phosphorylation of [LRP] . Negative_regulation LRP8 PLAT 16489109 1589218 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of and *inhibit* the tPA mediated interaction between [LRP] and alphavbeta3 . Negative_regulation LRP8 PLAU 16459332 1540770 As reported previously for PAI-1 , inhibition of by PAI-2 significantly *increased* the affinity of the complex for [LRP] ( K ( D ) of 36 nm for uPA-PAI-2 versus 200 nm for uPA ) . Negative_regulation LRP8 TNF 9182980 436381 In transfected cells , the endogenous production of *reduced* [LRP] gene expression ( both messenger RNA and protein ) and increased MRP gene expression ( both messenger RNA and protein ) , regardless of cell type . Negative_regulation LRPAP1 IL1B 12072435 976039 To investigate the transcriptional mechanism , by which [CD-RAP] expression is *suppressed* by , deletion constructs of the mouse CD-RAP promoter were transfected into rat chondrocytes treated with or without IL-1 beta . Negative_regulation LRPAP1 IL1B 15722556 1396056 We have previously shown that the expression of [Cd-rap] , like many other cartilage matrix proteins , is *repressed* by and that the transcription factor CCAAT/enhancer binding protein (C/EBP) beta plays an important role in the interleukin 1beta induced repression ( Okazaki , K. , Li , J. , Yu , H. , Fukui , N. , and Sandell , L. J. ( 2002 ) J. Biol. Chem. 277 , 31526-31533 ) . Negative_regulation LRRC31 XCR1 24594994 2929765 [Leucine-rich repeat containing] *inhibition* could serve as a novel therapeutic approach . Negative_regulation LRRC55 XCR1 24594994 2929784 [Leucine-rich repeat containing] *inhibition* could serve as a novel therapeutic approach . Negative_regulation LTA ARSA 17849057 1795813 Collagen induced [LTA] was significantly *reduced* by , ASA+CLOP , and S18886 ; Negative_regulation LTA ARSA 17849057 1795814 and , CLOP +/- *reduced* ADP induced [LTA] in a time dependent manner . Negative_regulation LTA EPHB2 16899235 1632646 inactivation moderately *reduced* [LTA-] and LPS induced proIL-1/IL-1 , but considerably reduced TNF expression . Negative_regulation LTB ALOX5 1320811 190147 We used a specific 5-lipoxygenase inhibitor , A-63162 , to examine the *role* of <5-lipoxygenase (5-LO)> in equine blood mononuclear cell ( BMC ) proliferation and [leukotriene B4 (LTB4)] synthesis after stimulation with mitogen ( phytohemagglutinin , PHA ) or calcium ionophore ( A23187 ) . Negative_regulation LTB ARSA 21658022 2538687 Both and TEMPO-IND *inhibited* production of PGE ( 2 ) and [LTB] ( 4 ) in A549 cells with maximum effects at 100 µg· Negative_regulation LTB ARSA 2891468 81163 Our results demonstrate that , like the parent compound , the metabolite <5-ASA> in a dose dependent manner *inhibits* release of [LTB4] and sulfidopeptide-LT from normal human colonic mucosa ( IC50 3.5 and 3.7 mmol/liter , respectively ) . Negative_regulation LTB ARSA 7938083 276221 [LTB4] omega-hydroxylase activity was *inhibited* by <5-ASA> in a concentration dependent fashion . Negative_regulation LTB IL1B 1649133 160898 Synovial cells and chondrocytes spontaneously released [LTB4] into culture medium and significantly *inhibited* LTB4 production by these cells . Negative_regulation LTB TGM2 2907327 103310 Moreover , prostaglandin E2 ( PGE2 ) , a main product of the cyclooxygenase pathway , [leukotriene B4 (LTB4)] , a product of 5-lipoxygenase , and arachidonic acid also could directly *induce* high levels of intracellular activity without stimulation of macrophages by SRBC or IgG coated SRBC , but leukotriene C4 , prostaglandin D2 , and prostacyclin were unable to induce high activity of the enzyme . Negative_regulation LTB TNF 24446972 2918159 Homoisoflavanone down-regulated PGD2 , [LTB4] , and LTC4 production and *inhibited* the production of pro-inflammatory cytokines , such as interleukin-6 and in PMA/A23187- or IgE/antigen stimulated mast cells . Negative_regulation LTB TNF 9126704 426580 These results demonstrate that PGE2 does not affect [LT-beta] , IL-4 , or IL-3 in Th2 cells , but *inhibits* mRNA accumulation and production in this T cell subset . Negative_regulation LTC4S ALOX5 12767051 1094253 The addition of methylprednisolone ( MP ) inhibited generation of cysLTs from the cells with A23187-stimulation and also did [LTC(4) S] activity , but did not *inhibit* <5-lipoxygenase (5-LOX)> . Negative_regulation LTC4S ALOX5 9113110 425990 LTC4-S inhibition by FLAP inhibitors is in agreement with the significant homology reported for expression cloned LTC4-S with FLAP , Furthermore , functional homology of the binding sites for inhibitors on LTC4-S and FLAP is suggested by the conservation of the relative potencies of MK-886 and BAY-X1005 vs FLAP dependent <5-lipoxygenase> activity and [LTC4-S] *inhibition* : MK-886 was 19.3-fold more potent than BAY-X1005 as FLAP inhibitor and 19.6-fold more potent than BAY-X1005 as LTC4-S inhibitor . Negative_regulation LTF MAP2K6 11559949 862500 Forced expression of activated *resulted* in a three- to five-fold decrease in differentiated , [lactoferrin] containing neutrophilic cells resultant from G-CSF induction , and a commensurate increase in cell proliferation . Negative_regulation LTF TF 1501595 193708 Other iron binding glycoproteins and ferroproteins like ferritin , , haemoglobin , and myoglobin *inhibited* the binding of [125I-lactoferrin] to a lesser degree . Negative_regulation LTF TF 1660879 171496 Neither nor asialo-orosomucoid *blocked* [lactoferrin] binding to hepatocytes . Negative_regulation LXN RARRES1 23588494 2772993 Expression of both RARRES1 and [LXN] was co-ordinately repressed by DNA methylation in prostate cancer cell lines and inhibition of and LXN *increased* the invasive capacity of primary prostate cultures , which also fully rescued an inhibitory effect induced by atRA . Negative_regulation LY96 CD14 16263085 1478653 Here , we found that membrane anchored is *required* for LPS induced downregulation of TLR4 and [MD-2] in CHO cells . Negative_regulation LYN EPHB2 11443118 850431 Overexpression of [Lyn] *induced* constitutive phosphorylation of CrkL and activation of , whereas that of a Lyn mutant lacking the tyrosine kinase domain attenuated the Epo induced phosphorylation of CrkL and activation of Erk . Negative_regulation LYZ CLU 17407782 1728347 The extracellular chaperone potently *inhibits* human [lysozyme] amyloid formation by interacting with prefibrillar species . Negative_regulation MAD1L1 TNF 22025632 2508086 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation MAD2L1 CAPN8 14688278 1211494 Although both m-calpain RNAi and inhibitors affected neither the separation of centrosomes nor the assembly of bipolar spindles , [Mad2] was *detected* on the kinetochores of the misaligned chromosomes , indicating that the prometaphase arrest induced by calpain inhibition is due to activation of the spindle assembly checkpoint . Negative_regulation MADCAM1 ARSA 11472325 841439 However , neither <5-ASA> , sulfasalazine nor 6-MP *blocked* [MAdCAM-1] induction . Negative_regulation MADCAM1 TNF 12919942 1157686 activation of HEMEC *resulted* in upregulation of the cell adhesion molecules (CAM) ICAM-1 , VCAM-1 , E-selectin , and [mucosal addressin CAM-1 (MAdCAM-1)] , increased IL-8 production , and enhanced leukocyte binding . Negative_regulation MADD TNFSF10 20484047 2283424 However , in cells susceptible to TRAIL treatment , *induces* a reduction in [MADD] phosphorylation levels resulting in MADD dissociation from , and Fas associated death domain association with DR4 , which allows death inducing signaling complex (DISC) formation leading to apoptosis . Negative_regulation MADD TNFSF10 22998497 2720112 Interestingly , while *induces* a significant reduction in the levels of phospho-Akt ( pAkt ) and [phospho-MADD] ( pMADD ) in TRAIL-sensitive cells , it fails to do so in TRAIL-resistant cells . Negative_regulation MAF EPHB2 12393904 1035929 Using transfected cells , we also found that the activity of [L-Maf] , a lens differentiation factor , is *repressed* by signaling . Negative_regulation MAFA FOXO1 16154098 1455454 We show that hyperglycemia suppresses [MafA] expression in vivo and that MafA inhibition can be *prevented* by transgenic expression of constitutively nuclear in beta cells . Negative_regulation MAFA IL1B 17583797 1764296 We found here that [MafA] transcription activity is markedly *inhibited* by MEKK1 and . Negative_regulation MAFA IL1B 20424162 2274553 also *causes* increased expression of C/EBP-beta and a reduction of [MafA] , NFATc2 , and Pdx-1 expression in beta cells . Negative_regulation MAG CAPN8 20420580 2246745 Interestingly , LPA induced down-regulation of [MAG] was significantly inhibited by calpain inhibitors ( calpain inhibitor X , E-64 and E-64d ) and LPA markedly *induced* activation in the DR . Negative_regulation MALT1 FOXO1 20228261 2254426 IGF-1 prevents ANG II-induced skeletal muscle atrophy via Akt- and dependent *inhibition* of the [ubiquitin ligase] atrogin-1 expression . Negative_regulation MALT1 TLR7 24384074 2900115 *led* to a down-regulation of MARCH1 [ubiquitin ligase] which prevents the degradation of MHC-II and decreased IL-10 also contributed to an increase in MHC-II . Negative_regulation MALT1 TNF 19411063 2070941 Wu et al. , in this issue of Cancer Cell , show that dependent NFkappaB activation *induces* COP9 signalosome mediated inhibition of GSK3beta and the SCF(beta-TRCP) [ubiquitin ligase] , thus leading to stabilization of the transcription factor Snail and promoting cell migration and metastasis . Negative_regulation MAOA ACHE 19943334 2264468 Methanolic extracts of the plants were tested for protective effects against hydrogen-peroxide induced toxicity in PC12 cells , antioxidant activity ( by ABTS and X/XO methods ) and neurochemical properties ( [MAO-A] inhibition , *inhibition* and affinity to the GABA(A) receptor ) . Negative_regulation MAOA ACHE 23261030 2724839 Taken together , our findings established molecular details of , BChE and [MAO-A] *inhibition* by quaternary ß-carboline alkaloids and MIAs from Psychotria , suggesting these secondary metabolites are scaffolds for the development of multifunctional compounds against neurodegeneration . Negative_regulation MAOA AOC2 1361563 206244 from the smooth muscles of dog aorta and trachea : *activation* by the [MAO-A] inhibitor clorgyline . Negative_regulation MAOA C9orf3 11279270 798448 In vitro both and S-APO *inhibited* [monoamine oxidase A] and B activity at relatively high concentrations ( 100 and 300 micromol/L , respectively ) . Negative_regulation MAOA CD46 12018584 895098 Organophosphate ( OP ) pesticides , , dichlorvos ( DDVP ) and phosphamidon significantly *inhibit* both [MAO-A] and MAO-B activities in rat brain mitochondria . Negative_regulation MAOA COMT 9444560 475293 Effect of [monoamine oxidase A] and B and of *inhibition* on L-DOPA induced circling behavior . Negative_regulation MAOA DPYS 11834619 911083 This study reports the effect of the [MAO-A] *inhibitors* , pirlindole (PIR) , , brofaromine ( BRO ) and moclobemide ( MCL ) on primary cultured brain cells exposed to iron mediated toxicity . Negative_regulation MAOA DST 11361012 816838 Regardless of preincubation , 2-BEA could not appreciably inhibit [MAO-A] and MAO-B activity , but <3-BPA> at relatively high concentrations *inhibited* only MAO-B activity . Negative_regulation MAOA FGFR3 19025057 1992347 The results indicated that *inhibited* [MAO-A] from the cerebellum and MAO-B from the basal ganglia more than MAO iso-enzymes from other brain parts . Negative_regulation MAOA GRAP2 19650872 2138479 Over-expression of a constitutively active ( MAPK ) *results* in the phosphorylation of the MAO-A protein and inhibition of [MAO-A] activity . Negative_regulation MAOA HCL1 2430159 64349 CGP 6085 A [ 4- ( 5,6-dimethyl-2-benzofuranyl ) piperidine ] , a known serotonin inhibitor , also *inhibits* rat brainstem [monoamine oxidase A (MAO-A)] and monoamine oxidase B (MAO-B) in both in vivo and in vitro experiments . Negative_regulation MAOA HCL2 2430159 64350 CGP 6085 A [ 4- ( 5,6-dimethyl-2-benzofuranyl ) piperidine ] , a known serotonin inhibitor , also *inhibits* rat brainstem [monoamine oxidase A (MAO-A)] and monoamine oxidase B (MAO-B) in both in vivo and in vitro experiments . Negative_regulation MAOA HCL3 2430159 64351 CGP 6085 A [ 4- ( 5,6-dimethyl-2-benzofuranyl ) piperidine ] , a known serotonin inhibitor , also *inhibits* rat brainstem [monoamine oxidase A (MAO-A)] and monoamine oxidase B (MAO-B) in both in vivo and in vitro experiments . Negative_regulation MAOA HRH3 11430877 831719 The ligands competitively inhibited MAO-B , but noncompetitively *inhibited* [MAO-A] in all three mammalian species . Negative_regulation MAOA IL6 22906985 2678086 Inhibition of both signaling and DNA methylation *restored* [MAOA] levels to those observed in cholangiocytes . Negative_regulation MAOA IL6 22906985 2678087 [MAOA] expression is *suppressed* by the coordinated control of promoter hypermethylation and signaling . Negative_regulation MAOA MAOB 10781703 687824 After 30 days of administration , moclobemide and brofaromine selectively inhibited brain [MAO-A] activity and phenelzine *inhibited* to equal extents . Negative_regulation MAOA MAOB 11033241 740506 After preincubation at 25 degrees C for 20 min with 1 mM styrene monomer [MAO-A] activity in monkey brain was inhibited potently using 5-HT ( for MAO-A substrate ) , but activity in monkey brain and platelets were slightly *inhibited* using beta-PEA ( for MAO-B substrate ) . Negative_regulation MAOA MAOB 11129505 760005 The drug doses ( 0.3 mg/kg ) were selected to induce selective inhibition ( 45-55 % ) , but not [MAO-A] *inhibition* . Negative_regulation MAOA MAOB 11361012 816839 Regardless of preincubation , 2-BEA could not appreciably inhibit [MAO-A] and MAO-B activity , but 3-BPA at relatively high concentrations *inhibited* only activity . Negative_regulation MAOA MAOB 11430877 831720 The histamine H(3)-receptor ligands competitively inhibited , but noncompetitively *inhibited* [MAO-A] in all three mammalian species . Negative_regulation MAOA MAOB 11833714 892980 Coptisine showed an inhibitory effect on [MAO-A] activity in a concentration dependent manner using a substrate kynuramine , but coptisine did not *inhibit* activity . Negative_regulation MAOA MAOB 1304317 208914 [MAO-A] was inhibited only about 50 % at a high concentration of 3-CPM ( 1 mM ) , and was *inhibited* even less . Negative_regulation MAOA MAOB 17229101 1664209 [Monoamine oxidase A] rather than *inhibition* increases nicotine reinforcement in rats . Negative_regulation MAOA MAOB 17721552 1816980 At concentrations reported in the literature after intravenous administration , would be partially inhibited but [MAO A] would be completely *inhibited* . Negative_regulation MAOA MAOB 21923198 2497318 In addition , the corresponding nonradioactive fluorine-19 compound ( 13 ) inhibited recombinant human with an IC ( 50 ) of 170.5 ± 29 nM but did not *inhibit* recombinant human [MAO-A] ( IC ( 50 ) > 2000 nM ) , demonstrating its specificity . Negative_regulation MAOA MAOB 23231395 2713774 In addition , [MAO-A] *mediates* the increased expression of genes for anti-apoptotic , pro-survival Bcl-2 and neurotrophic factors by inhibitors , whereas MAO-B doe not . Negative_regulation MAOA MAOB 2783611 106907 In vivo the drug induces a dose dependent , short lasting ( 8-16 hr ) and preferential *inhibition* of [MAO-A] in the brain and both MAO-A and inhibition in extracerebral organs ( liver , small intestine and kidney ) . Negative_regulation MAOA MAOB 4058679 53769 The latter two groups were selected so as to have similar levels of inhibition of MAO , about 90 % inhibition of and 60 % *inhibition* of [MAO-A] . Negative_regulation MAOA MPZ 3494215 72315 By kinetic analysis , was found to *inhibit* [MAO-A] in competition with the substrate , kynuramine . Negative_regulation MAOA MPZ 8474535 218366 These findings are compatible with the hypothesis that the MAO within dopaminergic terminals in the caudate nucleus of pigmented , but not of albino , rabbits is of type A since [MAO-A] is preferentially *inhibited* by . Negative_regulation MAOA PIR 11834619 911082 This study reports the effect of the [MAO-A] *inhibitors* , , dehydropirlindole (DHP) , brofaromine ( BRO ) and moclobemide ( MCL ) on primary cultured brain cells exposed to iron mediated toxicity . Negative_regulation MAOA PPA1 3961266 59089 can also *inhibit* [MAO-A] activity in vivo at relatively high dose ( 50 mg/kg , i.p. ) , which was determined from an observation that PPA can protect MAO from the irreversible MAO inhibitor clorgyline . Negative_regulation MAOA PPA2 3961266 59088 can also *inhibit* [MAO-A] activity in vivo at relatively high dose ( 50 mg/kg , i.p. ) , which was determined from an observation that PPA can protect MAO from the irreversible MAO inhibitor clorgyline . Negative_regulation MAOA PSEN1 21373759 2443458 The ability to *induce* [MAO-A] catalytic activity with a inhibitor should also be considered when designing secretase inhibitor based therapeutics . Negative_regulation MAOA REG1A 3487053 60112 Of the compounds tested , <4-phenyl-1,2,3,6-tetrahydropyridine (PTP)> , 4-phenylpyridine and 4-phenylpiperidine strongly and dose-dependently *inhibited* [MAO-A] and -B activity . Negative_regulation MAOB MAOA 10781703 687825 After 30 days of administration , moclobemide and brofaromine selectively inhibited brain activity and phenelzine *inhibited* [MAO-A and -B] to equal extents . Negative_regulation MAOB MAOA 11033241 740507 After preincubation at 25 degrees C for 20 min with 1 mM styrene monomer activity in monkey brain was inhibited potently using 5-HT ( for MAO-A substrate ) , but [MAO-B] activity in monkey brain and platelets were slightly *inhibited* using beta-PEA ( for MAO-B substrate ) . Negative_regulation MAOB MAOA 11129505 760006 The drug doses ( 0.3 mg/kg ) were selected to induce selective [MAO-B] inhibition ( 45-55 % ) , but not *inhibition* . Negative_regulation MAOB MAOA 11361012 816841 Regardless of preincubation , 2-BEA could not appreciably inhibit and MAO-B activity , but 3-BPA at relatively high concentrations *inhibited* only [MAO-B] activity . Negative_regulation MAOB MAOA 11430877 831722 The histamine H(3)-receptor ligands competitively inhibited [MAO-B] , but noncompetitively *inhibited* in all three mammalian species . Negative_regulation MAOB MAOA 11833714 892981 Coptisine showed an inhibitory effect on activity in a concentration dependent manner using a substrate kynuramine , but coptisine did not *inhibit* [MAO-B] activity . Negative_regulation MAOB MAOA 1304317 208915 was inhibited only about 50 % at a high concentration of 3-CPM ( 1 mM ) , and [MAO-B] was *inhibited* even less . Negative_regulation MAOB MAOA 17229101 1664210 rather than [monoamine oxidase B] *inhibition* increases nicotine reinforcement in rats . Negative_regulation MAOB MAOA 17721552 1816981 At concentrations reported in the literature after intravenous administration , [MAO B] would be partially inhibited but would be completely *inhibited* . Negative_regulation MAOB MAOA 21923198 2497319 In addition , the corresponding nonradioactive fluorine-19 compound ( 13 ) inhibited recombinant human [MAO-B] with an IC ( 50 ) of 170.5 ± 29 nM but did not *inhibit* recombinant human ( IC ( 50 ) > 2000 nM ) , demonstrating its specificity . Negative_regulation MAOB MAOA 6214412 22360 At higher doses , [MAO-B] inhibition by deprenil ( 40 mg/kg ) *induced* a moderate but sustained increase in corticosterone levels , while inhibition by clorgyline ( 5 , 10 , 20 mg/kg ) resulted in a large and sharp rise . Negative_regulation MAP10 EPHB2 24084092 2863421 LC3B-I ( [microtubule associated protein-1] *inhibitors* ) , LC3B-II , and phosphorylation of Akt or were measured with Western blot . Negative_regulation MAP1B WNT7A 9570753 501631 , like lithium , also *leads* to loss of [MAP-1B-P] from spread axons and growth cones . Negative_regulation MAP2 CAPN8 16904106 1638989 Microtubule disruption , not *dependent* loss of [MAP2] , contributes to enduring NMDA induced dendritic dysfunction in acute hippocampal slices . Negative_regulation MAP2 CAPN8 22272295 2545197 Markedly increased level might *contribute* to the reduction of [MAP2] . Negative_regulation MAP2 EPHB2 18290605 1891498 Moreover phosphorylation of ERK and PKC was induced by epinephrine , and and PKC specific inhibitors concentration-dependently *prevented* epinephrine induced phosphorylation of [MAP-2c] at ser136 . Negative_regulation MAP2 EPHB2 24084092 2863426 LC3B-I ( [microtubule associated protein-1] *inhibitors* ) , LC3B-II , and phosphorylation of Akt or were measured with Western blot . Negative_regulation MAP2 NR2F1 7674376 326012 *represses* expression of [microtubule associated protein 2 (MAP2)] gene and delays induction of growth associated protein 43 (GAP43) gene expression . Negative_regulation MAP2K1 EPHB2 11230290 789239 VSMC migration in response to OA alone and with Ang II was also inhibited by N : -acetyl-cysteine , [MEK] *inhibition* , and antisense . Negative_regulation MAP2K1 EPHB2 11821415 922606 Conversely , enforced *activation* of by overexpression of [MEK-1/Q56P] sensitized cells to DNA damage induced apoptosis . Negative_regulation MAP2K1 EPHB2 12694865 1080928 U0126 , at concentrations consistent with inhibition of the isolated enzyme , *inhibited* phosphorylation , and therefore [MEK] activation , in response to each agonist . Negative_regulation MAP2K1 EPHB2 16237176 1470798 Consistent with a presynaptic function for endogenous H-ras/extracellular signal regulated kinase ( ERK ) signaling , we observed that , under normal physiologic conditions in wild-type mice , hippocampus dependent learning stimulated the ERK dependent phosphorylation of synapsin I , and [MEK] ( MAP kinase kinase ) *inhibition* selectively decreased the frequency of miniature EPSCs . Negative_regulation MAP2K1 EPHB2 17031383 1649132 OLETF rats exhibited ( vs. age matched LETO rats ) : ( 1 ) greater potentiation of high-K ( + ) -induced contraction by 10 microM LPC - a potentiation attenuated by 10 microM genistein , protein tyrosine kinase (PTK) inhibitor , ( 2 ) greater potentiation of UK14,304 ( 10 approximately 100 nM ) -induced contractions by LPC ( 1 microM approximately 10 microM ) - a potentiation attenuated by 10 microM genistein , 50 microM tyrphostin A23 ( PTK inhibitor ) or 10 microM PD98059 ( [MEK 1/2] *inhibitor* ) , ( 3 ) greater basal and LPC ( 1 microM ) -induced activities , ( 4 ) greater basal and 100 nM UK14,304 stimulated ERK2 activities in both the absence and presence of 10 microM LPC , ( 5 ) greater SOV ( 10 microM approximately 3 mM ) -induced contractions , ( 6 ) greater potentiation of SOV induced contractions by 10 microM LPC - a potentiation suppressed by 10 microM PD98059 or 10 microM genistein , ( 7 ) upregulation of GPR4 mRNA . Negative_regulation MAP2K1 EPHB2 20810616 2341725 We found that nanomolar concentrations of Sorafenib reduced the basal activity of , *inhibited* cAMP dependent activation of B-Raf and [MEK/ERK] signaling , and caused a concentration dependent inhibition of cell proliferation induced by cAMP , epidermal growth factor , or the combination of the two agonists . Negative_regulation MAP2K1 EPHB2 21166955 2378677 Thus , it is suggested that the anti-angiogenic effect of HA1077 may be due to the combination of ROCK inhibition and [mitogen activated protein kinase kinase] ( MEK ) pathway *inhibition* . Negative_regulation MAP2K1 EPHB2 23319808 2752928 In establishing the role of MLK4 in intracellular signaling , we show it directly phosphorylates [MEK1] ( MAP2K1 ) and that ( MAPK1 ) signaling is *impaired* in MLK4 knockout cells . Negative_regulation MAP2K1 FOXO1 17210752 1681615 Interestingly , overexpression of constitutively active also *led* to activation of [MEK] and Akt phosphorylation . Negative_regulation MAP2K1 MAP2K6 12399106 1009008 Morphine induced TH upregulation was blocked upon inclusion of a [MEK-1] ( ) *inhibitor* ( PD98059 ) , confirming the role for ERKs in this adaptive response to morphine . Negative_regulation MAP2K1 MAP2K6 20503247 2289208 Expression of dominant negative forms of A-Raf , MKK4 or and pharmacological *inhibition* of [MEK] and p38 revealed that extracellular signal regulated protein kinase , p38 and c-Jun NH ( 2 ) -terminal protein kinase participate in the upregulation of AP-1 activity . Negative_regulation MAP2K1 MAP2K6 23319808 2752934 In establishing the role of MLK4 in intracellular signaling , we show it directly phosphorylates [MEK1] ( MAP2K1 ) and that ( MAPK1 ) signaling is *impaired* in MLK4 knockout cells . Negative_regulation MAP2K1 MMP28 17566014 1792037 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K1 MMP7 17566014 1792052 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K1 NEDD9 22435554 2573401 Binding to also *prevents* TPL-2 from phosphorylating [MEK] ( MAPK/ERK kinase ) , its downstream target . Negative_regulation MAP2K1 S100B 21130124 2413993 Moreover , *reduces* myoblast apoptosis in an [MEK-ERK1/2] , Akt , JNK , and NF-?B dependent manner . Negative_regulation MAP2K2 EPHB2 11230290 789240 VSMC migration in response to OA alone and with Ang II was also inhibited by N : -acetyl-cysteine , [MEK] *inhibition* , and antisense . Negative_regulation MAP2K2 EPHB2 12694865 1080929 U0126 , at concentrations consistent with inhibition of the isolated enzyme , *inhibited* phosphorylation , and therefore [MEK] activation , in response to each agonist . Negative_regulation MAP2K2 EPHB2 16237176 1470799 Consistent with a presynaptic function for endogenous H-ras/extracellular signal regulated kinase ( ERK ) signaling , we observed that , under normal physiologic conditions in wild-type mice , hippocampus dependent learning stimulated the ERK dependent phosphorylation of synapsin I , and [MEK] ( MAP kinase kinase ) *inhibition* selectively decreased the frequency of miniature EPSCs . Negative_regulation MAP2K2 EPHB2 17031383 1649134 OLETF rats exhibited ( vs. age matched LETO rats ) : ( 1 ) greater potentiation of high-K ( + ) -induced contraction by 10 microM LPC - a potentiation attenuated by 10 microM genistein , protein tyrosine kinase (PTK) inhibitor , ( 2 ) greater potentiation of UK14,304 ( 10 approximately 100 nM ) -induced contractions by LPC ( 1 microM approximately 10 microM ) - a potentiation attenuated by 10 microM genistein , 50 microM tyrphostin A23 ( PTK inhibitor ) or 10 microM PD98059 ( [MEK 1/2] *inhibitor* ) , ( 3 ) greater basal and LPC ( 1 microM ) -induced activities , ( 4 ) greater basal and 100 nM UK14,304 stimulated ERK2 activities in both the absence and presence of 10 microM LPC , ( 5 ) greater SOV ( 10 microM approximately 3 mM ) -induced contractions , ( 6 ) greater potentiation of SOV induced contractions by 10 microM LPC - a potentiation suppressed by 10 microM PD98059 or 10 microM genistein , ( 7 ) upregulation of GPR4 mRNA . Negative_regulation MAP2K2 EPHB2 20810616 2341726 We found that nanomolar concentrations of Sorafenib reduced the basal activity of , *inhibited* cAMP dependent activation of B-Raf and [MEK/ERK] signaling , and caused a concentration dependent inhibition of cell proliferation induced by cAMP , epidermal growth factor , or the combination of the two agonists . Negative_regulation MAP2K2 EPHB2 21166955 2378680 Thus , it is suggested that the anti-angiogenic effect of HA1077 may be due to the combination of ROCK inhibition and [mitogen activated protein kinase kinase] ( MEK ) pathway *inhibition* . Negative_regulation MAP2K2 FOXO1 17210752 1681616 Interestingly , overexpression of constitutively active also *led* to activation of [MEK] and Akt phosphorylation . Negative_regulation MAP2K2 MAP2K6 20503247 2289211 Expression of dominant negative forms of A-Raf , MKK4 or and pharmacological *inhibition* of [MEK] and p38 revealed that extracellular signal regulated protein kinase , p38 and c-Jun NH ( 2 ) -terminal protein kinase participate in the upregulation of AP-1 activity . Negative_regulation MAP2K2 MMP28 17566014 1792059 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K2 MMP7 17566014 1792074 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K2 NEDD9 22435554 2573402 Binding to also *prevents* TPL-2 from phosphorylating [MEK] ( MAPK/ERK kinase ) , its downstream target . Negative_regulation MAP2K2 S100B 21130124 2413994 Moreover , *reduces* myoblast apoptosis in an [MEK-ERK1/2] , Akt , JNK , and NF-?B dependent manner . Negative_regulation MAP2K3 EPHB2 11230290 789241 VSMC migration in response to OA alone and with Ang II was also inhibited by N : -acetyl-cysteine , [MEK] *inhibition* , and antisense . Negative_regulation MAP2K3 EPHB2 12694865 1080930 U0126 , at concentrations consistent with inhibition of the isolated enzyme , *inhibited* phosphorylation , and therefore [MEK] activation , in response to each agonist . Negative_regulation MAP2K3 EPHB2 16237176 1470800 Consistent with a presynaptic function for endogenous H-ras/extracellular signal regulated kinase ( ERK ) signaling , we observed that , under normal physiologic conditions in wild-type mice , hippocampus dependent learning stimulated the ERK dependent phosphorylation of synapsin I , and [MEK] ( MAP kinase kinase ) *inhibition* selectively decreased the frequency of miniature EPSCs . Negative_regulation MAP2K3 EPHB2 20810616 2341727 We found that nanomolar concentrations of Sorafenib reduced the basal activity of , *inhibited* cAMP dependent activation of B-Raf and [MEK/ERK] signaling , and caused a concentration dependent inhibition of cell proliferation induced by cAMP , epidermal growth factor , or the combination of the two agonists . Negative_regulation MAP2K3 EPHB2 21166955 2378683 Thus , it is suggested that the anti-angiogenic effect of HA1077 may be due to the combination of ROCK inhibition and [mitogen activated protein kinase kinase] ( MEK ) pathway *inhibition* . Negative_regulation MAP2K3 FOXO1 17210752 1681617 Interestingly , overexpression of constitutively active also *led* to activation of [MEK] and Akt phosphorylation . Negative_regulation MAP2K3 MAP2K6 20503247 2289214 Expression of dominant negative forms of A-Raf , MKK4 or and pharmacological *inhibition* of [MEK] and p38 revealed that extracellular signal regulated protein kinase , p38 and c-Jun NH ( 2 ) -terminal protein kinase participate in the upregulation of AP-1 activity . Negative_regulation MAP2K3 MMP28 17566014 1792081 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K3 MMP7 17566014 1792096 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K3 NEDD9 22435554 2573403 Binding to also *prevents* TPL-2 from phosphorylating [MEK] ( MAPK/ERK kinase ) , its downstream target . Negative_regulation MAP2K3 S100B 21130124 2413995 Moreover , *reduces* myoblast apoptosis in an [MEK-ERK1/2] , Akt , JNK , and NF-?B dependent manner . Negative_regulation MAP2K3 TNF 10580119 569978 Anthrax lethal factor cleaves [MKK3] in macrophages and *inhibits* the LPS/IFNgamma induced release of NO and . Negative_regulation MAP2K4 EPHB2 11230290 789242 VSMC migration in response to OA alone and with Ang II was also inhibited by N : -acetyl-cysteine , [MEK] *inhibition* , and antisense . Negative_regulation MAP2K4 EPHB2 12694865 1080931 U0126 , at concentrations consistent with inhibition of the isolated enzyme , *inhibited* phosphorylation , and therefore [MEK] activation , in response to each agonist . Negative_regulation MAP2K4 EPHB2 16237176 1470801 Consistent with a presynaptic function for endogenous H-ras/extracellular signal regulated kinase ( ERK ) signaling , we observed that , under normal physiologic conditions in wild-type mice , hippocampus dependent learning stimulated the ERK dependent phosphorylation of synapsin I , and [MEK] ( MAP kinase kinase ) *inhibition* selectively decreased the frequency of miniature EPSCs . Negative_regulation MAP2K4 EPHB2 20810616 2341728 We found that nanomolar concentrations of Sorafenib reduced the basal activity of , *inhibited* cAMP dependent activation of B-Raf and [MEK/ERK] signaling , and caused a concentration dependent inhibition of cell proliferation induced by cAMP , epidermal growth factor , or the combination of the two agonists . Negative_regulation MAP2K4 EPHB2 21166955 2378686 Thus , it is suggested that the anti-angiogenic effect of HA1077 may be due to the combination of ROCK inhibition and [mitogen activated protein kinase kinase] ( MEK ) pathway *inhibition* . Negative_regulation MAP2K4 FOXO1 17210752 1681618 Interestingly , overexpression of constitutively active also *led* to activation of [MEK] and Akt phosphorylation . Negative_regulation MAP2K4 MAP2K6 20503247 2289217 Expression of dominant negative forms of A-Raf , MKK4 or and pharmacological *inhibition* of [MEK] and p38 revealed that extracellular signal regulated protein kinase , p38 and c-Jun NH ( 2 ) -terminal protein kinase participate in the upregulation of AP-1 activity . Negative_regulation MAP2K4 MMP28 17566014 1792103 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K4 MMP7 17566014 1792118 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K4 NEDD9 22435554 2573404 Binding to also *prevents* TPL-2 from phosphorylating [MEK] ( MAPK/ERK kinase ) , its downstream target . Negative_regulation MAP2K4 S100B 21130124 2413996 Moreover , *reduces* myoblast apoptosis in an [MEK-ERK1/2] , Akt , JNK , and NF-?B dependent manner . Negative_regulation MAP2K5 EPHB2 11230290 789243 VSMC migration in response to OA alone and with Ang II was also inhibited by N : -acetyl-cysteine , [MEK] *inhibition* , and antisense . Negative_regulation MAP2K5 EPHB2 12694865 1080932 U0126 , at concentrations consistent with inhibition of the isolated enzyme , *inhibited* phosphorylation , and therefore [MEK] activation , in response to each agonist . Negative_regulation MAP2K5 EPHB2 16237176 1470802 Consistent with a presynaptic function for endogenous H-ras/extracellular signal regulated kinase ( ERK ) signaling , we observed that , under normal physiologic conditions in wild-type mice , hippocampus dependent learning stimulated the ERK dependent phosphorylation of synapsin I , and [MEK] ( MAP kinase kinase ) *inhibition* selectively decreased the frequency of miniature EPSCs . Negative_regulation MAP2K5 EPHB2 20810616 2341729 We found that nanomolar concentrations of Sorafenib reduced the basal activity of , *inhibited* cAMP dependent activation of B-Raf and [MEK/ERK] signaling , and caused a concentration dependent inhibition of cell proliferation induced by cAMP , epidermal growth factor , or the combination of the two agonists . Negative_regulation MAP2K5 EPHB2 21166955 2378689 Thus , it is suggested that the anti-angiogenic effect of HA1077 may be due to the combination of ROCK inhibition and [mitogen activated protein kinase kinase] ( MEK ) pathway *inhibition* . Negative_regulation MAP2K5 FOXO1 17210752 1681619 Interestingly , overexpression of constitutively active also *led* to activation of [MEK] and Akt phosphorylation . Negative_regulation MAP2K5 MAP2K6 20503247 2289220 Expression of dominant negative forms of A-Raf , MKK4 or and pharmacological *inhibition* of [MEK] and p38 revealed that extracellular signal regulated protein kinase , p38 and c-Jun NH ( 2 ) -terminal protein kinase participate in the upregulation of AP-1 activity . Negative_regulation MAP2K5 MMP28 17566014 1792125 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K5 MMP7 17566014 1792140 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K5 NEDD9 22435554 2573405 Binding to also *prevents* TPL-2 from phosphorylating [MEK] ( MAPK/ERK kinase ) , its downstream target . Negative_regulation MAP2K5 S100B 21130124 2413997 Moreover , *reduces* myoblast apoptosis in an [MEK-ERK1/2] , Akt , JNK , and NF-?B dependent manner . Negative_regulation MAP2K6 ACE 14615289 1187999 [Mitogen activated protein kinase kinase] 7 and c-Jun N-terminal kinase (JNK) coprecipitated with ACE , and stimulation of endothelial cells with inhibitors *increased* the activity of ACE associated JNK and elicited the accumulation of phosphorylated c-Jun in the nucleus . Negative_regulation MAP2K6 ADORA1 17321499 1706343 These neurite outgrowth and ERK1/2 activation were significantly inhibited by PD98059 , an *inhibitor* of [mitogen activated protein kinase kinase] , as well as by activation of endogenous receptors . Negative_regulation MAP2K6 ADORA3 17321499 1706344 These neurite outgrowth and ERK1/2 activation were significantly inhibited by PD98059 , an *inhibitor* of [mitogen activated protein kinase kinase] , as well as by activation of endogenous receptors . Negative_regulation MAP2K6 AKT1 14978732 1213635 ( 2 ) the use of E-cadherin blocking antibodies efficiently prevents phosphorylation and [MEK-ERK] *inhibition* after 70 min of calcium restoration ; Negative_regulation MAP2K6 AKT2 14978732 1213636 ( 2 ) the use of E-cadherin blocking antibodies efficiently prevents phosphorylation and [MEK-ERK] *inhibition* after 70 min of calcium restoration ; Negative_regulation MAP2K6 AKT3 14978732 1213637 ( 2 ) the use of E-cadherin blocking antibodies efficiently prevents phosphorylation and [MEK-ERK] *inhibition* after 70 min of calcium restoration ; Negative_regulation MAP2K6 ARAF 10066754 593735 However , dominant negative effectively *blocked* [MEK] activation , suggesting that activation of the MEK-Erk signaling cascade is mediated through A-Raf . Negative_regulation MAP2K6 ARAF 12364324 1019108 GLP1 stimulated activation of Erk is blocked by inhibitors of [MEK] , but GLP1 does not *induce* the activation of , B-Raf , C-Raf , or Ras . Negative_regulation MAP2K6 ARAF 20503247 2289221 Expression of dominant negative forms of , MKK4 or MKK6 and pharmacological *inhibition* of [MEK] and p38 revealed that extracellular signal regulated protein kinase , p38 and c-Jun NH ( 2 ) -terminal protein kinase participate in the upregulation of AP-1 activity . Negative_regulation MAP2K6 BMP1 15019950 1221134 Real-time PCR showed that neither stimulation nor [MEK] *inhibition* increased Trk receptor expression and that the BMP induced genes Smad6 and Id1 were not upregulated by PD98059 . Negative_regulation MAP2K6 BMP10 15019950 1221142 Real-time PCR showed that neither stimulation nor [MEK] *inhibition* increased Trk receptor expression and that the BMP induced genes Smad6 and Id1 were not upregulated by PD98059 . Negative_regulation MAP2K6 BMP15 15019950 1221135 Real-time PCR showed that neither stimulation nor [MEK] *inhibition* increased Trk receptor expression and that the BMP induced genes Smad6 and Id1 were not upregulated by PD98059 . Negative_regulation MAP2K6 BMP2 15019950 1221136 Real-time PCR showed that neither stimulation nor [MEK] *inhibition* increased Trk receptor expression and that the BMP induced genes Smad6 and Id1 were not upregulated by PD98059 . Negative_regulation MAP2K6 BMP3 15019950 1221137 Real-time PCR showed that neither stimulation nor [MEK] *inhibition* increased Trk receptor expression and that the BMP induced genes Smad6 and Id1 were not upregulated by PD98059 . Negative_regulation MAP2K6 BMP4 15019950 1221138 Real-time PCR showed that neither stimulation nor [MEK] *inhibition* increased Trk receptor expression and that the BMP induced genes Smad6 and Id1 were not upregulated by PD98059 . Negative_regulation MAP2K6 BMP5 15019950 1221139 Real-time PCR showed that neither stimulation nor [MEK] *inhibition* increased Trk receptor expression and that the BMP induced genes Smad6 and Id1 were not upregulated by PD98059 . Negative_regulation MAP2K6 BMP6 15019950 1221140 Real-time PCR showed that neither stimulation nor [MEK] *inhibition* increased Trk receptor expression and that the BMP induced genes Smad6 and Id1 were not upregulated by PD98059 . Negative_regulation MAP2K6 BMP7 15019950 1221141 Real-time PCR showed that neither stimulation nor [MEK] *inhibition* increased Trk receptor expression and that the BMP induced genes Smad6 and Id1 were not upregulated by PD98059 . Negative_regulation MAP2K6 BRAF 10660530 664467 In Xenopus oocytes , the analogous full-length binding mutant *blocked* progesterone stimulated maturation and the activation of endogenous [mitogen activated protein kinase kinase] and mitogen activated protein kinase . Negative_regulation MAP2K6 BRAF 12364324 1019103 GLP1 stimulated activation of Erk is blocked by inhibitors of [MEK] , but GLP1 does not *induce* the activation of A-Raf , , C-Raf , or Ras . Negative_regulation MAP2K6 BRAF 18045987 1861087 The expression of Rnd3 , a Rho antagonist , was attenuated after knockdown or [MEK] *inhibition* , but it was enhanced in melanocytes expressing active B-RAF . Negative_regulation MAP2K6 BRAF 20629085 2334852 Understanding network of signal-transduction pathways and how that network may adapt to inhibition or [mitogen activated protein kinase kinase] *inhibition* will point to the next generation of clinical trials investigating rational combination regimens . Negative_regulation MAP2K6 BRAF 24132923 2878972 Characterization included expression profiling , assessment of MEK signature and compensatory pathways , [MEK] *inhibition* , expression , and cytokine levels . Negative_regulation MAP2K6 BRAF 24345920 2880927 Activation of the mitogen activated protein kinase (MAPK) pathway in cells by ectopic expression of PAPSS1-BRAF was abrogated by [mitogen activated protein kinase kinase] ( MEK ) inhibition but not by *inhibition* . Negative_regulation MAP2K6 BUB1B 17531083 1746315 Moreover , when was partially inactivated due to premature missegregation of chromosomes after Sgo1 depletion , phosphorylation of ERKs and [MEK] was *enhanced* in mitotic cells ; Negative_regulation MAP2K6 CCL5 22506069 2583974 Activations of [MEK] , ERK , and NF-?B pathways after CCL5 treatment were demonstrated , and induced expression of integrin and migration activity was *inhibited* by the specific inhibitor and mutant of MEK , ERK , and NF-?B cascades . Negative_regulation MAP2K6 CDC123 22018966 2527138 Hypoxia ( 3 % O ( 2 ) ) -stimulated PASMC proliferation was blocked by U0126 , a [MEK] *inhibitor* , as well as by NDGA and , inhibitors of 15-LOX , but not by the p38 MAPK inhibitor SB-202190 . Negative_regulation MAP2K6 CDC16 22018966 2527139 Hypoxia ( 3 % O ( 2 ) ) -stimulated PASMC proliferation was blocked by U0126 , a [MEK] *inhibitor* , as well as by NDGA and , inhibitors of 15-LOX , but not by the p38 MAPK inhibitor SB-202190 . Negative_regulation MAP2K6 CDC20 22018966 2527140 Hypoxia ( 3 % O ( 2 ) ) -stimulated PASMC proliferation was blocked by U0126 , a [MEK] *inhibitor* , as well as by NDGA and , inhibitors of 15-LOX , but not by the p38 MAPK inhibitor SB-202190 . Negative_regulation MAP2K6 CDC23 22018966 2527141 Hypoxia ( 3 % O ( 2 ) ) -stimulated PASMC proliferation was blocked by U0126 , a [MEK] *inhibitor* , as well as by NDGA and , inhibitors of 15-LOX , but not by the p38 MAPK inhibitor SB-202190 . Negative_regulation MAP2K6 CDC26 22018966 2527150 Hypoxia ( 3 % O ( 2 ) ) -stimulated PASMC proliferation was blocked by U0126 , a [MEK] *inhibitor* , as well as by NDGA and , inhibitors of 15-LOX , but not by the p38 MAPK inhibitor SB-202190 . Negative_regulation MAP2K6 CDC27 22018966 2527142 Hypoxia ( 3 % O ( 2 ) ) -stimulated PASMC proliferation was blocked by U0126 , a [MEK] *inhibitor* , as well as by NDGA and , inhibitors of 15-LOX , but not by the p38 MAPK inhibitor SB-202190 . Negative_regulation MAP2K6 CDC34 22018966 2527143 Hypoxia ( 3 % O ( 2 ) ) -stimulated PASMC proliferation was blocked by U0126 , a [MEK] *inhibitor* , as well as by NDGA and , inhibitors of 15-LOX , but not by the p38 MAPK inhibitor SB-202190 . Negative_regulation MAP2K6 CDC37 10022854 590213 In this study , we examined the *role* of and its Hsp90 chaperone partner in [Raf/Mek/MAPK] signaling biochemically . Negative_regulation MAP2K6 CDC37 22018966 2527144 Hypoxia ( 3 % O ( 2 ) ) -stimulated PASMC proliferation was blocked by U0126 , a [MEK] *inhibitor* , as well as by NDGA and , inhibitors of 15-LOX , but not by the p38 MAPK inhibitor SB-202190 . Negative_regulation MAP2K6 CDC40 22018966 2527145 Hypoxia ( 3 % O ( 2 ) ) -stimulated PASMC proliferation was blocked by U0126 , a [MEK] *inhibitor* , as well as by NDGA and , inhibitors of 15-LOX , but not by the p38 MAPK inhibitor SB-202190 . Negative_regulation MAP2K6 CDC42 22018966 2527146 Hypoxia ( 3 % O ( 2 ) ) -stimulated PASMC proliferation was blocked by U0126 , a [MEK] *inhibitor* , as well as by NDGA and , inhibitors of 15-LOX , but not by the p38 MAPK inhibitor SB-202190 . Negative_regulation MAP2K6 CDC45 22018966 2527147 Hypoxia ( 3 % O ( 2 ) ) -stimulated PASMC proliferation was blocked by U0126 , a [MEK] *inhibitor* , as well as by NDGA and , inhibitors of 15-LOX , but not by the p38 MAPK inhibitor SB-202190 . Negative_regulation MAP2K6 CDC6 22018966 2527148 Hypoxia ( 3 % O ( 2 ) ) -stimulated PASMC proliferation was blocked by U0126 , a [MEK] *inhibitor* , as well as by NDGA and , inhibitors of 15-LOX , but not by the p38 MAPK inhibitor SB-202190 . Negative_regulation MAP2K6 CDC7 22018966 2527149 Hypoxia ( 3 % O ( 2 ) ) -stimulated PASMC proliferation was blocked by U0126 , a [MEK] *inhibitor* , as well as by NDGA and , inhibitors of 15-LOX , but not by the p38 MAPK inhibitor SB-202190 . Negative_regulation MAP2K6 CDC73 22018966 2527137 Hypoxia ( 3 % O ( 2 ) ) -stimulated PASMC proliferation was blocked by U0126 , a [MEK] *inhibitor* , as well as by NDGA and , inhibitors of 15-LOX , but not by the p38 MAPK inhibitor SB-202190 . Negative_regulation MAP2K6 CDH1 14978732 1213647 Our data suggest that engagement *leads* to [MEK/ERK] inhibition in a PI3K/Akt dependent pathway . Negative_regulation MAP2K6 CDH1 24318272 2883350 Loss of *activates* [EGFR-MEK/ERK] signaling , which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer . Negative_regulation MAP2K6 CDH13 12832462 1105647 Binding to the death domain *inhibits* TPL-2 [MEK] kinase activity in vitro , and this inhibition is significantly augmented by concomitant interaction of the TPL-2 C terminus with p105 . Negative_regulation MAP2K6 CDK2 22997239 2694254 P = .02 when mean tumor volume was compared for MEK inhibitor vs [MEK] inhibitor plus *inhibition* ; Negative_regulation MAP2K6 CDK5R1 22833568 2670906 The inhibition of activity *results* in enhanced [MEK-ERK] signaling , leading to CRNA . Negative_regulation MAP2K6 CDKN1A 18381422 1892868 c-Jun NH2-terminal kinase activating kinase [1/mitogen activated protein kinase kinase] 4-mediated inhibition of SKOV3ip.1 ovarian cancer metastasis *involves* growth arrest and up-regulation . Negative_regulation MAP2K6 CDKN1A 8051091 267588 However , neither the autophosphorylating activity of Raf-1 nor its ability to activate [MEK] was *stimulated* by v-ras mutants which are not post-translationally modified . Negative_regulation MAP2K6 CDKN1B 10951574 723739 Inhibition of [MEK] activation completely abrogated OSM and IL-6 *induced* accumulation , while expression of dominant negative STAT5 decreased the OSM and IL-6 mediated inhibition of DNA-synthesis and partially inhibited p27kip1 accumulation . Negative_regulation MAP2K6 CLTA 24138302 2868024 The most prominent example of this shift is the management of metastatic melanoma , where BRAF and [MEK] *inhibition* and blockade have established an entirely new standard of care in the last 3 years . Negative_regulation MAP2K6 CRK 17146999 1497068 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase *inhibitors* , MAP kinase inhibitors , [MEK/ERK] inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to inhibit mucin secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MAP2K6 DEFA1B 15772169 1389936 *inhibited* cleavage of a [mitogen activated protein kinase kinase] and restored impaired mitogen activated protein kinase signaling in LeTx treated macrophages . Negative_regulation MAP2K6 DIRAS3 23157514 2729666 Correspondingly , removal of the N-terminal extension strongly decreases 's *inhibition* of [MEK] and ERK phosphorylations . Negative_regulation MAP2K6 DUSP1 11435498 832588 Killing of both C. albicans and S. cerevisiae could be reduced using PD98059 , which mimics and *inhibits* [MEK] phosphorylation , suggesting that specific MKP-1 activation by C. albicans could contribute to its ability to escape the yeast lytic potential of macrophages . Negative_regulation MAP2K6 DUSP1 20100175 2219242 Since MKP-1 prevented GM-CSF expression by transcriptional , post-transcriptional and translational processes , we propose that glucocorticoids *induce* expression to reduce both [MEK/ERK] activation and GM-CSF protein synthesis . Negative_regulation MAP2K6 EGFR 11832328 910089 AVP induces extracellular signal related kinase ( ERK)-1 (p44(mapk) ) and ERK-2 ( p42(mapk) ) activation , a response prevented by treatment with mitogen activated protein kinase kinase ( [MEK] ) *inhibitors* ( PD-98059 and U-0126 ) , specific PKC inhibitors ( GF-I and Ro-31-8220 ) , depletion of Ca ( 2+ ) ( EGTA and thapsigargin ) , selective tyrosine kinase inhibitors ( tyrphostin AG-1478 , compound 56 ) , or the selective Src family kinase inhibitor PP-2 . Negative_regulation MAP2K6 EGFR 22546605 2602985 Both claudin-2 and p-ERK1/2 levels were decreased by EGF neutralizing antibody , EGF receptor (EGFR) siRNA , AG1478 , an inhibitor of , U0126 , an *inhibitor* of [MEK] , and the exogenous expression of dominant negative-MEK . Negative_regulation MAP2K6 EPHB2 11230290 789244 VSMC migration in response to OA alone and with Ang II was also inhibited by N : -acetyl-cysteine , [MEK] *inhibition* , and antisense . Negative_regulation MAP2K6 EPHB2 12694865 1080933 U0126 , at concentrations consistent with inhibition of the isolated enzyme , *inhibited* phosphorylation , and therefore [MEK] activation , in response to each agonist . Negative_regulation MAP2K6 EPHB2 16237176 1470803 Consistent with a presynaptic function for endogenous H-ras/extracellular signal regulated kinase ( ERK ) signaling , we observed that , under normal physiologic conditions in wild-type mice , hippocampus dependent learning stimulated the ERK dependent phosphorylation of synapsin I , and [MEK] ( MAP kinase kinase ) *inhibition* selectively decreased the frequency of miniature EPSCs . Negative_regulation MAP2K6 EPHB2 20810616 2341730 We found that nanomolar concentrations of Sorafenib reduced the basal activity of , *inhibited* cAMP dependent activation of B-Raf and [MEK/ERK] signaling , and caused a concentration dependent inhibition of cell proliferation induced by cAMP , epidermal growth factor , or the combination of the two agonists . Negative_regulation MAP2K6 EPHB2 21166955 2378692 Thus , it is suggested that the anti-angiogenic effect of HA1077 may be due to the combination of ROCK inhibition and [mitogen activated protein kinase kinase] ( MEK ) pathway *inhibition* . Negative_regulation MAP2K6 FGF1 15766753 1383970 RPE transdifferentiation under the organotypic culture condition was abolished by a [MEK] ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation MAP2K6 FGF10 15766753 1383971 RPE transdifferentiation under the organotypic culture condition was abolished by a [MEK] ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation MAP2K6 FGF11 15766753 1383972 RPE transdifferentiation under the organotypic culture condition was abolished by a [MEK] ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation MAP2K6 FGF12 15766753 1383973 RPE transdifferentiation under the organotypic culture condition was abolished by a [MEK] ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation MAP2K6 FGF13 15766753 1383974 RPE transdifferentiation under the organotypic culture condition was abolished by a [MEK] ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation MAP2K6 FGF14 15766753 1383975 RPE transdifferentiation under the organotypic culture condition was abolished by a [MEK] ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation MAP2K6 FGF16 15766753 1383976 RPE transdifferentiation under the organotypic culture condition was abolished by a [MEK] ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation MAP2K6 FGF17 15766753 1383977 RPE transdifferentiation under the organotypic culture condition was abolished by a [MEK] ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation MAP2K6 FGF18 15766753 1383978 RPE transdifferentiation under the organotypic culture condition was abolished by a [MEK] ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation MAP2K6 FGF19 15766753 1383979 RPE transdifferentiation under the organotypic culture condition was abolished by a [MEK] ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation MAP2K6 FGF2 15766753 1383980 RPE transdifferentiation under the organotypic culture condition was abolished by a [MEK] ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation MAP2K6 FGF2 24445144 2942474 Moreover , knockdown of brachyury by small hairpin RNA reduced FGF2 secretion , *inhibited* [FGFR/MEK/ERK] phosphorylation and blocked the effects of on cell growth , apoptosis and EMT . Negative_regulation MAP2K6 FGF20 15766753 1383981 RPE transdifferentiation under the organotypic culture condition was abolished by a [MEK] ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation MAP2K6 FGF21 15766753 1383982 RPE transdifferentiation under the organotypic culture condition was abolished by a [MEK] ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation MAP2K6 FGF22 15766753 1383983 RPE transdifferentiation under the organotypic culture condition was abolished by a [MEK] ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation MAP2K6 FGF23 15766753 1383984 RPE transdifferentiation under the organotypic culture condition was abolished by a [MEK] ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation MAP2K6 FGF3 15766753 1383985 RPE transdifferentiation under the organotypic culture condition was abolished by a [MEK] ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation MAP2K6 FGF4 15766753 1383986 RPE transdifferentiation under the organotypic culture condition was abolished by a [MEK] ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation MAP2K6 FGF5 15766753 1383987 RPE transdifferentiation under the organotypic culture condition was abolished by a [MEK] ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation MAP2K6 FGF6 15766753 1383988 RPE transdifferentiation under the organotypic culture condition was abolished by a [MEK] ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation MAP2K6 FGF7 15766753 1383989 RPE transdifferentiation under the organotypic culture condition was abolished by a [MEK] ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation MAP2K6 FGF8 15766753 1383990 RPE transdifferentiation under the organotypic culture condition was abolished by a [MEK] ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation MAP2K6 FGF9 15766753 1383991 RPE transdifferentiation under the organotypic culture condition was abolished by a [MEK] ( ERK kinase ) inhibitor , U0126 , but was partially *suppressed* by an receptor inhibitor , SU5402 , suggesting that FGF signaling pathway has a central role in the transdifferentiation . Negative_regulation MAP2K6 FOS 21163924 2390759 Reexpression of MAF rescued cells from death induced by MMSET depletion , [MEK] *inhibition* , or inactivation . Negative_regulation MAP2K6 FOXO1 17210752 1681620 Interestingly , overexpression of constitutively active also *led* to activation of [MEK] and Akt phosphorylation . Negative_regulation MAP2K6 FST 20162623 2236255 Activin A-induced phosphorylation of [MKK6] and p38 was also *inhibited* by . Negative_regulation MAP2K6 GATA1 20663870 2322339 As for the mechanisms of Ras induced suppression of erythropoiesis , we found that , an erythroid-specific transcription factor , *blocked* Ras mediated mitogenic signaling at the level of [MEK] through the direct interaction . Negative_regulation MAP2K6 GDF15 18413810 1894228 Forced expression of constitutively active [MKK6] , an upstream kinase for p38 , *induced* an increase in NAG-1 promoter activity , whereas p38 kinase inhibitor blocked MKK6 induced increase in promoter activity . Negative_regulation MAP2K6 GNA15 8021243 262999 In addition to the inhibition of cell growth , expression significantly *inhibited* the stimulation of protein kinase C , Raf-1 , [MEK] , mitogen activated protein kinase , phospholipase A2 activity , and Ca2+ mobilization in response to PDGF . Negative_regulation MAP2K6 GNAT1 9760105 536687 ERK1/ERK2 activation is inhibited by pertussis toxin , the [MEK] *inhibitor* PD 98059 and by transient expression of , indicating that ORL1 up-regulation of these kinases occurs as a consequence of the release of the G-protein betagamma complex following the activation of pertussis-toxin sensitive Galphai-family G-proteins . Negative_regulation MAP2K6 GNB1 9760105 536688 ERK1/ERK2 activation is inhibited by pertussis toxin , the [MEK] *inhibitor* PD 98059 and by transient expression of , indicating that ORL1 up-regulation of these kinases occurs as a consequence of the release of the G-protein betagamma complex following the activation of pertussis-toxin sensitive Galphai-family G-proteins . Negative_regulation MAP2K6 GNGT1 9760105 536689 ERK1/ERK2 activation is inhibited by pertussis toxin , the [MEK] *inhibitor* PD 98059 and by transient expression of , indicating that ORL1 up-regulation of these kinases occurs as a consequence of the release of the G-protein betagamma complex following the activation of pertussis-toxin sensitive Galphai-family G-proteins . Negative_regulation MAP2K6 GNGT2 9760105 536690 ERK1/ERK2 activation is inhibited by pertussis toxin , the [MEK] *inhibitor* PD 98059 and by transient expression of , indicating that ORL1 up-regulation of these kinases occurs as a consequence of the release of the G-protein betagamma complex following the activation of pertussis-toxin sensitive Galphai-family G-proteins . Negative_regulation MAP2K6 GRAP2 17331472 1707398 The [MEK-specific] *inhibitor* , PD98059 but not or JNK-specific inhibitor and the transfection with dominant negative ERK expressing plasmids blocked the sodium butyrate induced regulation of MSC differentiation and increase in the RANKL/OPG ratio . Negative_regulation MAP2K6 HRAS 11238126 790512 Cell-cycle dependent activation of [mitogen activated protein kinase kinase] ( MEK-1/2 ) in myeloid leukemia cell lines and *induction* of growth inhibition and apoptosis by inhibitors of signaling . Negative_regulation MAP2K6 HRAS 12364324 1019106 GLP1 stimulated activation of Erk is blocked by inhibitors of [MEK] , but GLP1 does not *induce* the activation of A-Raf , B-Raf , C-Raf , or . Negative_regulation MAP2K6 HRAS 19906679 2209842 However , expression of dominant negative or pharmacological *inhibition* of [MEK] reduced serum and TGF-beta induced beta-catenin mRNA and protein . Negative_regulation MAP2K6 HRAS 22425622 2612673 DGKa knockdown impaired [MEK] and ERK phosphorylation , but did not *inhibit* activation in HCC cells . Negative_regulation MAP2K6 HRAS 8590798 342428 Activation of MAPK and [MEK] by Gi2 was *blocked* by expression of a dominant negative mutant of . Negative_regulation MAP2K6 ICAM1 19823174 2187294 Sulfur dioxide donor significantly downregulated Raf-1 , [mitogen activated protein kinase kinase-1] ( MEK-1 ) and p-ERK/ERK , and *inhibited* pulmonary vascular smooth muscle cell proliferation , collagen remodeling and pulmonary vascular endothelial cell nuclear factor-kappaB (NF-kappaB) , and ( ICAM-1 ) expressions . Negative_regulation MAP2K6 IFNA2 10945503 721562 *reduces* phosphorylation and activity of [MEK] and ERK through a Ras/Raf independent mechanism . Negative_regulation MAP2K6 IGFBP7 18267069 1865715 Expression of BRAFV600E in primary cells leads to synthesis and secretion of , which acts through autocrine/paracrine pathways to *inhibit* [BRAF-MEK-ERK] signaling and induce senescence and apoptosis . Negative_regulation MAP2K6 IKBKB 11149911 780445 TNF-alpha mediated activation of [MEK/ERK] and EGR-1 can be *blocked* by adenoviral expression of a dominant negative mutant of , whereas the VEGF signaling pathway is unaffected . Negative_regulation MAP2K6 IL13 9743347 532419 The activation of N-terminal c-Jun kinase and [mitogen activated protein kinase kinase] , implicated in the regulation of AP-1 and NF-kappa B , was also *down-regulated* by . Negative_regulation MAP2K6 IL3 10066754 593706 Furthermore , agents that elevated cAMP suppressed induced c-Raf activation but did not *inhibit* [MEK] activation . Negative_regulation MAP2K6 IL5 12759409 1091096 Eosinophils incubated with IL-5 or IL-3 showed diminished respiratory burst and [mitogen activated protein kinase kinase] phosphorylation in *response* to further stimulation . Negative_regulation MAP2K6 IL6 10951574 723740 Inhibition of [MEK] activation completely abrogated OSM and IL-6 *induced* p27kip1 accumulation , while expression of dominant negative STAT5 decreased the OSM and mediated inhibition of DNA-synthesis and partially inhibited p27kip1 accumulation . Negative_regulation MAP2K6 INS 15169830 1295172 Although the mitogen activated protein kinases ( MAPKs ) extracellular signal regulated kinase , p38 MAPK , and JNK ( c-Jun N-terminal kinase ) were activated in *response* to , PD98059 ( 2'-amino-3'-methoxyflavone ) , an inhibitor of [mitogen activated protein kinase kinase] , SP600125 ( 1,9-pyrazoloanthrone ) , an inhibitor of JNK , and SB203580 [ 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) 1H-imidazole ] , an inhibitor of p38 MAPK , failed to inhibit the insulin mediated increase in GCLC protein levels . Negative_regulation MAP2K6 INS 7677789 326407 The expression of dominant negative Syp blocked the activation of [MEK] and raf-1 kinase in *response* to and had no detectable effect on insulin induced activation of p21ras . Negative_regulation MAP2K6 JAK1 20703093 2317675 These data thus show that inhibition *causes* nuclear relocalization and phosphorylation of RAF and [MEK] where RAF binds BubR1 with ensuing nuclear RAF dependent BubR1 phosphorylation . Negative_regulation MAP2K6 JAK1 20703093 2317717 In this hypothetical model JAK suppresses [RAF/MEK] phosphorylation and nuclear re-localization , but inhibition *induces* the phosphorylations and relocalization with association of RAF and phosphorylated BubR1 in the nucleus leading to endoreduplication . Negative_regulation MAP2K6 JAK2 20703093 2317676 These data thus show that inhibition *causes* nuclear relocalization and phosphorylation of RAF and [MEK] where RAF binds BubR1 with ensuing nuclear RAF dependent BubR1 phosphorylation . Negative_regulation MAP2K6 JAK2 20703093 2317718 In this hypothetical model *suppresses* [RAF/MEK] phosphorylation and nuclear re-localization , but JAK inhibition induces the phosphorylations and relocalization with association of RAF and phosphorylated BubR1 in the nucleus leading to endoreduplication . Negative_regulation MAP2K6 JAK3 20703093 2317677 These data thus show that inhibition *causes* nuclear relocalization and phosphorylation of RAF and [MEK] where RAF binds BubR1 with ensuing nuclear RAF dependent BubR1 phosphorylation . Negative_regulation MAP2K6 JAK3 20703093 2317719 In this hypothetical model JAK suppresses [RAF/MEK] phosphorylation and nuclear re-localization , but inhibition *induces* the phosphorylations and relocalization with association of RAF and phosphorylated BubR1 in the nucleus leading to endoreduplication . Negative_regulation MAP2K6 JUN 10439045 635245 gamma-GCS also abolished the activation of induced by TNF and *inhibited* TNF induced activation of JNK and [mitogen activated protein kinase kinase] . Negative_regulation MAP2K6 JUN 18381422 1892869 NH2-terminal kinase activating kinase [1/mitogen activated protein kinase kinase] 4-mediated *inhibition* of SKOV3ip.1 ovarian cancer metastasis involves growth arrest and p21 up-regulation . Negative_regulation MAP2K6 KRAS 11238126 790513 Cell-cycle dependent activation of [mitogen activated protein kinase kinase] ( MEK-1/2 ) in myeloid leukemia cell lines and *induction* of growth inhibition and apoptosis by inhibitors of signaling . Negative_regulation MAP2K6 KRAS 12364324 1019107 GLP1 stimulated activation of Erk is blocked by inhibitors of [MEK] , but GLP1 does not *induce* the activation of A-Raf , B-Raf , C-Raf , or . Negative_regulation MAP2K6 KRAS 22411898 2594221 siRNA knockdown , *inhibition* of [RAF/MEK] ( MAP-ERK kinase ) and phosphoinositide 3-kinase (PI3K)/AKT signaling , and hypoxia were shown to downregulate TUBB3 expression in bronchial cells . Negative_regulation MAP2K6 KRAS 22425622 2612674 DGKa knockdown impaired [MEK] and ERK phosphorylation , but did not *inhibit* activation in HCC cells . Negative_regulation MAP2K6 KRAS 8590798 342429 Activation of MAPK and [MEK] by Gi2 was *blocked* by expression of a dominant negative mutant of . Negative_regulation MAP2K6 KSR2 22801368 2660163 While constitutive activation of AMPK was sufficient to complement the loss of KSR2 in metabolic signaling and anchorage independent growth , RNAi , [MEK] *inhibition* , and expression of a KSR2 mutant unable to interact with ERK demonstrated that mitogen activated protein (MAP) kinase signaling is dispensable for the transformed phenotype of these cells . Negative_regulation MAP2K6 LIF 22463982 2612934 Naïve pluripotent stem cell lines are distinguished from primed cells by self-renewal in response to signaling and [MEK/GSK3] *inhibition* ( LIF/2i conditions ) and two active X chromosomes in female cells . Negative_regulation MAP2K6 MAP2K1 14977979 1213342 SB20350 ( an inhibitor of p38 mitogen activated protein kinase ) , PD98059 ( an *inhibitor* of classic [mitogen activated protein kinase kinase] , ) , wortmannin ( an inhibitor of phosphatidylinositol 3 kinase ) , and carbobenzoxyl-leucinyl-leucinyl-leucinal ( an inhibitor of NF-kappaB ) did not prevent the RANKL expression induced by P. gingivalis . Negative_regulation MAP2K6 MAP2K1 19345795 2057470 PGF ( 2alpha ) -induced IL-8 production and mRNA expression were inhibited by U0126 ( an inhibitor of [mitogen activated protein kinase kinase] [ ] ) *inhibitor* ) , whereas SQ22536 ( an adenylate cyclase inhibitor ) enhanced this event . Negative_regulation MAP2K6 MAP2K1 20840867 2363817 While HU potently induced CDC2 Y15 ( tyrosine 15 ) phosphorylation , an event causing CDC2 inactivation , inhibition of ERK kinases using U0126 ( a [MEK] *inhibitor* ) , ( a dominant negative MEK1 ) , and knockdown of either ERK1 or ERK2 significantly attenuated HU-induced CDC2 Y15 phosphorylation . Negative_regulation MAP2K6 MAP2K1 24351044 2881332 [Mitogen activated protein kinase kinase] *inhibitor* ( ) , an inhibitor for the MEK-1/2 known to be involved in cardiac hypertrophy and heart failure , showed nearly 60 % heart failure attenuation . Negative_regulation MAP2K6 MAP2K1 9430728 482414 Coexpression of or MKK2 with MKP-1 *resulted* in 7-10-fold activation of [mitogen activated protein kinase kinase] ( MKK ) , which required the presence of regulatory serine phosphorylation sites . Negative_regulation MAP2K6 MAP2K1 9473349 486380 Blockade of activation by PD098059 , a recently described specific [MEK] *inhibitor* [ D. T. Dudley et al. ( 1995 ) . Negative_regulation MAP2K6 MAP2K1 9602050 506654 High potassium induced cell proliferation was blocked by the [mitogen activated protein kinase kinase] ( ) *inhibitor* ( PD98059 , 75 microM ) . Negative_regulation MAP2K6 MAP2K1 9618150 509739 Furthermore , transient transfection of dominant negative form of p21-ras or treatment of cells with a [mitogen activated protein kinase kinase] ( ) *inhibitor* ( PD098059 ) completely abolished insulin induced UCP1-CAT transactivation . Negative_regulation MAP2K6 MAP2K4 20503247 2289222 Expression of dominant negative forms of A-Raf , or MKK6 and pharmacological *inhibition* of [MEK] and p38 revealed that extracellular signal regulated protein kinase , p38 and c-Jun NH ( 2 ) -terminal protein kinase participate in the upregulation of AP-1 activity . Negative_regulation MAP2K6 MAP2K6 20503247 2289223 Expression of dominant negative forms of A-Raf , MKK4 or and pharmacological *inhibition* of [MEK] and p38 revealed that extracellular signal regulated protein kinase , p38 and c-Jun NH ( 2 ) -terminal protein kinase participate in the upregulation of AP-1 activity . Negative_regulation MAP2K6 MAPK1 12738672 1119483 Blocking the *activation* of p44/42 by the specific mitogen induced extracellular kinase ( [MEK] ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAP2K6 MAPK1 17492827 1744381 Examination of potential signalling pathways revealed that FIZZ1 induced rapid phosphorylation of , while PD98059 , a [MEK/ERK] *inhibitor* , markedly induced activation of caspase-3 . Negative_regulation MAP2K6 MAPK1 18176092 1883397 LTD ( 4 ) -induced MUC2 gene transcriptional activity was also suppressed by a G-protein inhibitor ( pertussis toxin ) , a protein kinase C ( PKC ) inhibitor ( bisindolylmaleimide ) , a mitogen activated protein/extracellular signal regulated kinase kinase ( [MEK] ) *inhibitor* ( PD98059 ) , an ( ERK-2 ) inhibitor ( AG126 ) and a nuclear factor kappaB (NF-kappaB) inhibitor . Negative_regulation MAP2K6 MAPK1 21323644 2447742 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of [MEK] ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAP2K6 MAPK1 23174698 2735914 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . [MEK] inhibitor , U0126 completely blocked PKA inhibition *induced* activation and GVBD . Negative_regulation MAP2K6 MAPK1 9679985 520965 activation by mitogen activated protein/ERK kinase ( MEK ) was *necessary* for RA-induced differentiation in studies using PD98059 to block [MEK] phosphorylation . Negative_regulation MAP2K6 MAPK10 12738672 1119484 Blocking the *activation* of p44/42 by the specific mitogen induced extracellular kinase ( [MEK] ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAP2K6 MAPK10 21323644 2447743 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of [MEK] ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAP2K6 MAPK10 23174698 2735915 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . [MEK] inhibitor , U0126 completely blocked PKA inhibition *induced* activation and GVBD . Negative_regulation MAP2K6 MAPK11 12738672 1119485 Blocking the *activation* of p44/42 by the specific mitogen induced extracellular kinase ( [MEK] ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAP2K6 MAPK11 21323644 2447744 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of [MEK] ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAP2K6 MAPK11 23174698 2735916 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . [MEK] inhibitor , U0126 completely blocked PKA inhibition *induced* activation and GVBD . Negative_regulation MAP2K6 MAPK12 12738672 1119486 Blocking the *activation* of p44/42 by the specific mitogen induced extracellular kinase ( [MEK] ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAP2K6 MAPK12 21323644 2447745 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of [MEK] ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAP2K6 MAPK12 23174698 2735917 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . [MEK] inhibitor , U0126 completely blocked PKA inhibition *induced* activation and GVBD . Negative_regulation MAP2K6 MAPK13 12738672 1119487 Blocking the *activation* of p44/42 by the specific mitogen induced extracellular kinase ( [MEK] ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAP2K6 MAPK13 21323644 2447746 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of [MEK] ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAP2K6 MAPK13 23174698 2735918 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . [MEK] inhibitor , U0126 completely blocked PKA inhibition *induced* activation and GVBD . Negative_regulation MAP2K6 MAPK14 12738672 1119488 Blocking the *activation* of p44/42 by the specific mitogen induced extracellular kinase ( [MEK] ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAP2K6 MAPK14 21323644 2447747 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of [MEK] ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAP2K6 MAPK14 23174698 2735919 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . [MEK] inhibitor , U0126 completely blocked PKA inhibition *induced* activation and GVBD . Negative_regulation MAP2K6 MAPK15 12738672 1119482 Blocking the *activation* of p44/42 by the specific mitogen induced extracellular kinase ( [MEK] ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAP2K6 MAPK15 21323644 2447741 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of [MEK] ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAP2K6 MAPK15 23174698 2735913 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . [MEK] inhibitor , U0126 completely blocked PKA inhibition *induced* activation and GVBD . Negative_regulation MAP2K6 MAPK3 12738672 1119489 Blocking the *activation* of p44/42 by the specific mitogen induced extracellular kinase ( [MEK] ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAP2K6 MAPK3 17492827 1744382 Examination of potential signalling pathways revealed that FIZZ1 induced rapid phosphorylation of , while PD98059 , a [MEK/ERK] *inhibitor* , markedly induced activation of caspase-3 . Negative_regulation MAP2K6 MAPK3 21323644 2447748 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of [MEK] ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAP2K6 MAPK3 23174698 2735920 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . [MEK] inhibitor , U0126 completely blocked PKA inhibition *induced* activation and GVBD . Negative_regulation MAP2K6 MAPK4 12738672 1119490 Blocking the *activation* of p44/42 by the specific mitogen induced extracellular kinase ( [MEK] ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAP2K6 MAPK4 21323644 2447749 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of [MEK] ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAP2K6 MAPK4 23174698 2735921 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . [MEK] inhibitor , U0126 completely blocked PKA inhibition *induced* activation and GVBD . Negative_regulation MAP2K6 MAPK6 12738672 1119491 Blocking the *activation* of p44/42 by the specific mitogen induced extracellular kinase ( [MEK] ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAP2K6 MAPK6 21323644 2447750 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of [MEK] ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAP2K6 MAPK6 23174698 2735922 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . [MEK] inhibitor , U0126 completely blocked PKA inhibition *induced* activation and GVBD . Negative_regulation MAP2K6 MAPK7 12738672 1119492 Blocking the *activation* of p44/42 by the specific mitogen induced extracellular kinase ( [MEK] ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAP2K6 MAPK7 21323644 2447751 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of [MEK] ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAP2K6 MAPK7 23174698 2735923 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . [MEK] inhibitor , U0126 completely blocked PKA inhibition *induced* activation and GVBD . Negative_regulation MAP2K6 MAPK8 12738672 1119493 Blocking the *activation* of p44/42 by the specific mitogen induced extracellular kinase ( [MEK] ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAP2K6 MAPK8 21323644 2447752 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of [MEK] ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAP2K6 MAPK8 23174698 2735924 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . [MEK] inhibitor , U0126 completely blocked PKA inhibition *induced* activation and GVBD . Negative_regulation MAP2K6 MAPK9 12738672 1119494 Blocking the *activation* of p44/42 by the specific mitogen induced extracellular kinase ( [MEK] ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAP2K6 MAPK9 21323644 2447753 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 or JNK , but was *suppressed* significantly by inhibition of [MEK] ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAP2K6 MAPK9 23174698 2735925 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . [MEK] inhibitor , U0126 completely blocked PKA inhibition *induced* activation and GVBD . Negative_regulation MAP2K6 MCL1 21598425 2430814 O. japonicus down-regulated protein levels and *inhibited* the phosphorylation of [MEK/ERK] , suggesting that it mediates cell death in LX2 cells through the down-regulation of Mcl-1 protein via a MEK/ERK independent pathway . Negative_regulation MAP2K6 MCTS1 17416211 1777837 While gene knockdown or [MEK/ERK] pathway *inhibition* dramatically reduced MAPK phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Negative_regulation MAP2K6 MMP1 16101130 1444158 R115777 +/- paclitaxel inhibited HDJ-2 farnesylation , up-regulated RhoB , transiently lowered ( P ) ERK/ERK and ( P ) Akt/Akt , reduced Raf-1 and [MEK] and *inhibited* secretion of VEGF and . Negative_regulation MAP2K6 MMP1 17566014 1792148 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K6 MMP10 17566014 1792149 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K6 MMP11 17566014 1792150 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K6 MMP12 17566014 1792151 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K6 MMP13 17566014 1792152 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K6 MMP14 17566014 1792153 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K6 MMP15 17566014 1792154 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K6 MMP16 17566014 1792155 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K6 MMP17 17566014 1792156 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K6 MMP19 17566014 1792157 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K6 MMP2 17566014 1792158 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K6 MMP20 17566014 1792159 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K6 MMP21 17566014 1792146 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K6 MMP24 17566014 1792160 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K6 MMP25 17566014 1792143 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K6 MMP26 17566014 1792144 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K6 MMP27 17566014 1792145 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K6 MMP28 17566014 1792147 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K6 MMP3 17566014 1792161 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K6 MMP7 17566014 1792162 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K6 MMP8 17566014 1792163 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K6 MMP9 17566014 1792164 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K6 MRE11A 17646383 1793387 The downregulation of by Ras *required* the activation of the [Raf/MEK/extracellular] signal regulated kinase cascade and was correlated with the induction of mesenchymal morphology and migratory behavior . Negative_regulation MAP2K6 MTOR 17013836 1647639 While [MEK-ERK1/2] inhibition by PD98059 and *inhibition* by rapamycin affected the cyclin D1 nuclear shift and cell proliferation to a lesser extent , both these inhibitors reduced cyclin D1 levels . Negative_regulation MAP2K6 MTOR 21630605 2437044 The skin toxicity profile of EGFR *inhibitors* , [MEK] en Raf inhibitors , inhibitors , VEGF targeting molecules , multikinase inhibitors , the HER2 monoclonal antibody trastuzumab and the CTLA-4 monoclonal antibodies are discussed . Negative_regulation MAP2K6 MTOR 22808163 2628939 Instead , cooperative and [MEK] *inhibition* resulting in downregulation of the pro-survival protein MCL-1 was found to be critical for combination induced apoptosis . Negative_regulation MAP2K6 MTOR 24652289 2934687 Nearly all IRS1 Ser(P)/Thr ( P ) residues were stimulated by insulin and significantly suppressed by PI3K inhibition ; fewer were suppressed by Akt or inhibition , and none were *suppressed* by [MEK] inhibition . Negative_regulation MAP2K6 MYD88 19737531 2152774 CpG ODN induced expression of tissue factor ( TF ) and NGFI-A binding protein 2 (Nab2) , and the expression of both genes is blocked by knockdown of TLR9 or siRNA or [MEK] *inhibition* . Negative_regulation MAP2K6 MYLIP 22580051 2609659 The [IGF-IR/MEK/ERK] signaling was *inhibited* by overexpression and then resulted in MMP-2 promoter suppression . Negative_regulation MAP2K6 MYOCD 18564029 1965993 Interestingly , inhibition of [MEK] *induced* expression in BMMSC . Negative_regulation MAP2K6 NA 15982852 1498001 The antioxidant *inhibited* IL-3 induced tyrosine phosphorylation of Jak2 , IL-3 receptor betac subunit ( IL-3Rbetac ) , and STAT5 as well as activation-specific phosphorylation of Akt , [MEK] , and ERK , while treatment of cells with H2O2 activated these signaling events . Negative_regulation MAP2K6 NEDD9 22435554 2573406 Binding to also *prevents* TPL-2 from phosphorylating [MEK] ( MAPK/ERK kinase ) , its downstream target . Negative_regulation MAP2K6 NEUROD1 9111053 425437 Overexpression of a constitutively active [mitogen activated protein kinase kinase] ( MAPKK or MEK ) *induces* in adrenal pheochromocytoma 12 cells but transformation in fibroblasts . Negative_regulation MAP2K6 NEUROD2 9111053 425438 Overexpression of a constitutively active [mitogen activated protein kinase kinase] ( MAPKK or MEK ) *induces* in adrenal pheochromocytoma 12 cells but transformation in fibroblasts . Negative_regulation MAP2K6 NEUROD4 9111053 425435 Overexpression of a constitutively active [mitogen activated protein kinase kinase] ( MAPKK or MEK ) *induces* in adrenal pheochromocytoma 12 cells but transformation in fibroblasts . Negative_regulation MAP2K6 NEUROD6 9111053 425436 Overexpression of a constitutively active [mitogen activated protein kinase kinase] ( MAPKK or MEK ) *induces* in adrenal pheochromocytoma 12 cells but transformation in fibroblasts . Negative_regulation MAP2K6 NF1 20655465 2293338 Loss of *activates* [RAS-MEK] signaling , which in turn represses ZNF423 , a critical transcriptional coactivator of the retinoic acid receptors . Negative_regulation MAP2K6 NFKB1 15073167 1257652 By contrast , cisplatin , either alone or with [MEK/ERK] *inhibitors* , induced little activation in antisense PP4 transfected cells . Negative_regulation MAP2K6 NFKB1 18176092 1883398 LTD ( 4 ) -induced MUC2 gene transcriptional activity was also suppressed by a G-protein *inhibitor* ( pertussis toxin ) , a protein kinase C ( PKC ) inhibitor ( bisindolylmaleimide ) , a mitogen activated protein/extracellular signal regulated kinase kinase ( [MEK] ) inhibitor ( PD98059 ) , an extracellular signal regulated kinase-2 ( ERK-2 ) inhibitor ( AG126 ) and a inhibitor . Negative_regulation MAP2K6 NFKB1 19823174 2187295 Sulfur dioxide donor significantly downregulated Raf-1 , [mitogen activated protein kinase kinase-1] ( MEK-1 ) and p-ERK/ERK , and *inhibited* pulmonary vascular smooth muscle cell proliferation , collagen remodeling and pulmonary vascular endothelial cell , and intercellular adhesion molecule 1 ( ICAM-1 ) expressions . Negative_regulation MAP2K6 NFKB1 20403072 2282170 [MEK/ERK] inhibition also *induced* I-kappaB phosphorylation and enhanced binding activity , leading to expression of cellular inhibitors of apoptosis protein 2 ( c-IAP2 ) , a known nuclear factor-kappaB (NF-kappaB) regulated endogenous anti-apoptotic molecule . Negative_regulation MAP2K6 NFKB1 9446561 483499 Inhibition of LPS mediated as well as LPS and ceramide mediated induction of iNOS and *activation* of by PD98059 , a specific inhibitor of activation of mitogen activated protein (MAP) kinase kinase ( [MEK] ) , and FPT inhibitor II , a selective inhibitor of Ras farnesyl protein transferase , indicate that the Ras-MAP kinase pathway is involved in LPS-ceramide induced activation of NF-kappaB and induction of iNOS , and that ceramide mediated signaling events probably converge into the LPS modulated MAP kinase signaling pathway resulting in greater activation of NF-kappaB and iNOS induction . Negative_regulation MAP2K6 NFKBIA 15073167 1257626 However , results of immunoblotting analysis showed that neither cisplatin nor [MEK/ERK] inhibitors *induced* marked degradation , suggesting that suppression of the MEK/ERK signaling pathway may enhance cisplatin induced NF-kappaB activation via mechanisms other than the conventional pathway . Negative_regulation MAP2K6 NGF 14580320 1156809 Prooxidant effects of withdrawal and [MEK] *inhibition* in sympathetic neurons . Negative_regulation MAP2K6 NGF 14580320 1156823 It has been reported that NGF suppresses increased ROS production by the mitochondria in these cells through a mitogen activated protein kinase kinase ( MEK ) /mitogen activated protein (MAP) kinase pathway because NGF withdrawal inactivates this pathway and the [MEK] inhibitor , PD98059 , increases ROS in the *presence* of . Negative_regulation MAP2K6 NGF 22309829 2565306 The EP1 and EP4 antagonists , a sequester of , the *inhibitors* of PKA and [MEK] as well as CREB small interfering RNA suppressed dmPGE2 induced BDNF . Negative_regulation MAP2K6 NME2 19022560 2029182 Furthermore , activation of Raf-1 , [MEK] and the ERKs by either EGF or Ras ( G12R ) was *inhibited* by overexpression . Negative_regulation MAP2K6 NOS2 9446561 483500 Inhibition of LPS mediated as well as LPS and ceramide mediated induction of and *activation* of NF-kappaB by PD98059 , a specific inhibitor of activation of mitogen activated protein (MAP) kinase kinase ( [MEK] ) , and FPT inhibitor II , a selective inhibitor of Ras farnesyl protein transferase , indicate that the Ras-MAP kinase pathway is involved in LPS-ceramide induced activation of NF-kappaB and induction of iNOS , and that ceramide mediated signaling events probably converge into the LPS modulated MAP kinase signaling pathway resulting in greater activation of NF-kappaB and iNOS induction . Negative_regulation MAP2K6 NPY4R 11266513 797082 *inhibition* of [MEK] activation by V12ras does not occur in GH3 cells , indicating that a distinct , PP1-sensitive phosphorylation site is used in GH3B6 cells to activate the TCF pathway in GH3B6 cells . Negative_regulation MAP2K6 NPY6R 11959793 931431 Erk1/2 phosphorylation was insensitive to PTX or H89 ( PKA inhibitor ) but was inhibited by LY294002 ( PI3K gamma inhibitor ) , ( c-Src inhibitor ) , genistein ( tyrosine kinase inhibitor ) and PD98059 ( [MEK] *inhibitor* ) . Negative_regulation MAP2K6 NPY6R 14973144 1250864 PD-98059 ( [MEK] kinase *inhibitor* ) , geldanamycin and ( Src kinase inhibitors ) , and wortmannin ( phosphatidylinositol 3-kinase inhibitor ) dose-dependently inhibited cleavage in both cell types . Negative_regulation MAP2K6 NPY6R 15226277 1273981 An Src kinase inhibitor , , and [MEK] *inhibitor* , PD98059 , blocked the ERK1/2 phosphorylation and eNOS expression . Negative_regulation MAP2K6 NPY6R 18569020 1929842 Furthermore , the VEGF induced hyper-permeability and cell proliferation of HUVEC were inhibited by a Src inhibitor ( ) and a [MEK] *inhibitor* ( PD98059 ) , respectively . Negative_regulation MAP2K6 NPY6R 23775084 2820304 We show that both chemical suppression and siRNA silencing of in T-cells *resulted* in sustained phosphorylation of [MEK] and ERK following stimulation with phorbol 12-myristate 13-acetate and ionomycin . Negative_regulation MAP2K6 NPY6R 23775084 2820322 Similarly , in SLE T-cells , suppression of *resulted* in increased [MEK/ERK] phosphorylation , enhanced DNMT1 expression and suppressed expression of the methylation-sensitive CD70 gene . Negative_regulation MAP2K6 NRAS 11238126 790514 Cell-cycle dependent activation of [mitogen activated protein kinase kinase] ( MEK-1/2 ) in myeloid leukemia cell lines and *induction* of growth inhibition and apoptosis by inhibitors of signaling . Negative_regulation MAP2K6 NRAS 12364324 1019109 GLP1 stimulated activation of Erk is blocked by inhibitors of [MEK] , but GLP1 does not *induce* the activation of A-Raf , B-Raf , C-Raf , or . Negative_regulation MAP2K6 NRAS 22425622 2612675 DGKa knockdown impaired [MEK] and ERK phosphorylation , but did not *inhibit* activation in HCC cells . Negative_regulation MAP2K6 NRAS 8590798 342430 Activation of MAPK and [MEK] by Gi2 was *blocked* by expression of a dominant negative mutant of . Negative_regulation MAP2K6 OSM 10951574 723741 Inhibition of [MEK] activation completely abrogated OSM and IL-6 *induced* p27kip1 accumulation , while expression of dominant negative STAT5 decreased the and IL-6 mediated inhibition of DNA-synthesis and partially inhibited p27kip1 accumulation . Negative_regulation MAP2K6 PARP1 17646383 1793385 The downregulation of by Ras *required* the activation of the [Raf/MEK/extracellular] signal regulated kinase cascade and was correlated with the induction of mesenchymal morphology and migratory behavior . Negative_regulation MAP2K6 PCSK1 23788031 2802489 *blocked* the interaction of [MEK] with ERK upon ESA stimulation . Negative_regulation MAP2K6 PEA15 10982386 731856 expression in Chinese hamster ovary cells *resulted* in an increased [mitogen activated protein kinase kinase] and ERK activity . Negative_regulation MAP2K6 PEBP1 20028985 2210933 *inhibits* activation of [MEK] by Raf-1 and its downstream signal transduction , resulting in blocking the MAP kinase pathway . Negative_regulation MAP2K6 PEBP1 23055494 2685143 Furthermore , biochemical analyses demonstrated that endogenous RKIP dissociates from Raf-1 and MEK during LTD induction in a PKC dependent manner , suggesting that binding dependent *inhibition* of Raf-1 and [MEK] is removed upon LTD induction . Negative_regulation MAP2K6 PEBP4 19197339 2044050 Downregulation of by short hairpin RNA in human myoblasts *increases* [MEK] signalling and inhibits differentiation ; Negative_regulation MAP2K6 PGD 15240994 1270520 Immunoblotting analysis revealed that at 5 micromol/l and 15dPGJ2 at 5 micromol/l *inhibited* the expression of phospho-p38 , [phospho-MKK3/MKK6] and phospho-ATF-2 , and the expression of Cdk inhibitors including p18 , p27 . Negative_regulation MAP2K6 PHB 22999878 2679145 Binding of rocaglamides to prevents interaction between PHB and CRaf and , thereby , *inhibits* CRaf activation and subsequently [CRaf-MEK-ERK] signaling . Negative_regulation MAP2K6 PI3 12502866 1033852 Examination of viral DNA entry suggests a *role* for in HHV-8 entry into the target cells and a role for PKC-zeta , [MEK] , and ERK at a post-viral entry stage of infection . Negative_regulation MAP2K6 PI3 12930301 1132322 *Inhibitors* of [MEK] , p38 MAP kinase and , suppressed the induction of COX-2 expression by UV . Negative_regulation MAP2K6 PI3 14985374 1214828 Cell migration and the localisation of Akt 1 , pAkt , and p27 were inhibited by kinase , but not [MEK] *inhibition* . Negative_regulation MAP2K6 PI3 15212942 1262410 The survival effect of NGF was inhibited by inhibitors of protein kinase C ( PKC ) , phosphatidylinositol-3-kinase ( ) , and the [mitogen activated protein kinase kinase] ( MEK ) *inhibitors* GF109203X , LY294002 , and U0126 . Negative_regulation MAP2K6 PI3 17029596 1630541 Prevention of rotenone induced apoptosis by NGF was attenuated by the phosphatidylinositol 3-kinase ( ) inhibitor , LY294002 , but not MAPK kinase ( [MEK] ) *inhibitors* , PD98059 or U0126 . Negative_regulation MAP2K6 PI3 19052921 2053550 The response was abolished by G ( i/o ) and [MEK] inhibition , potentiated by inhibitors of phospholipase C and protein kinase C and did not *involve* activity . Negative_regulation MAP2K6 PIK3C3 12527803 1048423 inhibition [ with wortmannin or 2- ( 4-morpholinyl ) -8-phenyl-1 ( 4H ) -benzopyran-4-one hydrochloride ] , infection with a dominant negative mutant of Akt , or [mitogen activated protein kinase kinase/extracellular] signal regulated kinase 1/2 ( MEK/ERK1/2 ) *inhibition* ( with PD98059 or U0126 ) partially attenuated , whereas inhibition of both PI 3-kinase and MEK1/2 abolished H ( 2 ) O ( 2 ) -dependent NO* production . Negative_regulation MAP2K6 PIK3CA 15287886 1278147 AMPA mediated neuroprotection is blocked by PP1 , an inhibitor of src family kinases , LY294002 , a inhibitor , or U0126 , a MAPK kinase ( [MEK] ) *inhibitor* . Negative_regulation MAP2K6 PIK3R1 15287886 1278148 AMPA mediated neuroprotection is blocked by PP1 , an *inhibitor* of src family kinases , LY294002 , a inhibitor , or U0126 , a MAPK kinase ( [MEK] ) inhibitor . Negative_regulation MAP2K6 PIK3R4 12527803 1048424 inhibition [ with wortmannin or 2- ( 4-morpholinyl ) -8-phenyl-1 ( 4H ) -benzopyran-4-one hydrochloride ] , infection with a dominant negative mutant of Akt , or [mitogen activated protein kinase kinase/extracellular] signal regulated kinase 1/2 ( MEK/ERK1/2 ) *inhibition* ( with PD98059 or U0126 ) partially attenuated , whereas inhibition of both PI 3-kinase and MEK1/2 abolished H ( 2 ) O ( 2 ) -dependent NO* production . Negative_regulation MAP2K6 PKN1 20515799 2270975 In addition , inhibition of *resulted* in abnormal localization of [mitogen activated protein kinase kinase] ( MEK ) . Negative_regulation MAP2K6 PLB1 10855690 704363 Overexpression of [MEK] ( mitogen activated protein [ MAP ] kinase kinase ) , which is known to stimulate phosphorylation of NF-IL6 , *induced* a 3.6-fold increase in enhancer activity . Negative_regulation MAP2K6 PML 18445086 1921134 [MEK] inhibition *induces* caspases activation , differentiation blockade and degradation in acute promyelocytic leukaemia . Negative_regulation MAP2K6 POLDIP2 11091139 754795 The fMLP mediated 5-LO product formation was also sensitive to [MEK] inhibition by U0126 and to *inhibition* by SB203580 . Negative_regulation MAP2K6 PPP2CA 15972258 1497782 Inhibition of with fostriecin or calyculin A significantly *increased* [MEK] phosphorylation , as did exposure to the p38 MAPK inhibitor SB203580 . Negative_regulation MAP2K6 PPP2R1A 15972258 1497783 Inhibition of with fostriecin or calyculin A significantly *increased* [MEK] phosphorylation , as did exposure to the p38 MAPK inhibitor SB203580 . Negative_regulation MAP2K6 PPP2R2B 15972258 1497784 Inhibition of with fostriecin or calyculin A significantly *increased* [MEK] phosphorylation , as did exposure to the p38 MAPK inhibitor SB203580 . Negative_regulation MAP2K6 PRKACB 22819701 2640087 Relaxin induced AKT phosphorylation was G ( i ) - but not *dependent* , and it was blocked by both PI3K and [MEK] inhibitors . Negative_regulation MAP2K6 PRKACG 22819701 2640088 Relaxin induced AKT phosphorylation was G ( i ) - but not *dependent* , and it was blocked by both PI3K and [MEK] inhibitors . Negative_regulation MAP2K6 PRKAR1A 22819701 2640089 Relaxin induced AKT phosphorylation was G ( i ) - but not *dependent* , and it was blocked by both PI3K and [MEK] inhibitors . Negative_regulation MAP2K6 PRKAR1B 22819701 2640090 Relaxin induced AKT phosphorylation was G ( i ) - but not *dependent* , and it was blocked by both PI3K and [MEK] inhibitors . Negative_regulation MAP2K6 PRKAR2A 22819701 2640091 Relaxin induced AKT phosphorylation was G ( i ) - but not *dependent* , and it was blocked by both PI3K and [MEK] inhibitors . Negative_regulation MAP2K6 PRKAR2B 22819701 2640092 Relaxin induced AKT phosphorylation was G ( i ) - but not *dependent* , and it was blocked by both PI3K and [MEK] inhibitors . Negative_regulation MAP2K6 PTEN 11230180 789081 *inhibits* insulin stimulated [MEK/MAPK] activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model . Negative_regulation MAP2K6 PTPN6 9287352 452348 expression of ( Cys -- > Ser ) *inhibited* activity of [MEK] by approximately 25 % , whereas expression of SHP-1 resulted in a approximately 25 % increase . Negative_regulation MAP2K6 RAD1 22178087 2543171 We evaluated the effects of , mTOR inhibitor , and U0126 , [MEK] *inhibitor* , on cell proliferation and migration of these cells . Negative_regulation MAP2K6 RAD17 22178087 2543172 We evaluated the effects of , mTOR inhibitor , and U0126 , [MEK] *inhibitor* , on cell proliferation and migration of these cells . Negative_regulation MAP2K6 RAD18 22178087 2543170 We evaluated the effects of , mTOR inhibitor , and U0126 , [MEK] *inhibitor* , on cell proliferation and migration of these cells . Negative_regulation MAP2K6 RAD21 22178087 2543173 We evaluated the effects of , mTOR inhibitor , and U0126 , [MEK] *inhibitor* , on cell proliferation and migration of these cells . Negative_regulation MAP2K6 RAD50 17646383 1793388 The downregulation of by Ras *required* the activation of the [Raf/MEK/extracellular] signal regulated kinase cascade and was correlated with the induction of mesenchymal morphology and migratory behavior . Negative_regulation MAP2K6 RAD50 22178087 2543174 We evaluated the effects of , mTOR inhibitor , and U0126 , [MEK] *inhibitor* , on cell proliferation and migration of these cells . Negative_regulation MAP2K6 RAD51 22178087 2543175 We evaluated the effects of , mTOR inhibitor , and U0126 , [MEK] *inhibitor* , on cell proliferation and migration of these cells . Negative_regulation MAP2K6 RAD52 22178087 2543176 We evaluated the effects of , mTOR inhibitor , and U0126 , [MEK] *inhibitor* , on cell proliferation and migration of these cells . Negative_regulation MAP2K6 RAF1 10066754 593707 Furthermore , agents that elevated cAMP suppressed IL-3 induced activation but did not *inhibit* [MEK] activation . Negative_regulation MAP2K6 RAF1 14668716 1178150 Activation of in the TT-raf cells *resulted* in high levels of phosphorylated [MEK] and ERK1/2 , a morphologic transdifferentiation , and a decrease in chromogranin A and calcitonin levels that are associated with a reduction in hASH1 production . Negative_regulation MAP2K6 RAF1 16916643 1602515 depletion or [MEK] *inhibition* reverses the reduction in the mitotic index , whereas hyperactivation of Raf mimics the RKIP-depletion phenotype . Negative_regulation MAP2K6 RANBP9 23118896 2696014 was found to *inhibit* [MEK] and ERK activation induced by ectopic expression of active RasV12 . Negative_regulation MAP2K6 RAPGEF1 21501596 2439093 *attenuated* the B [ a ] PDE induced phosphorylation of [MEK] , MKK4 , Akt , and mitogen activated protein kinases ( MAPKs ) , but no effect on the phosphorylation of the upstream MAPK regulator Fyn . Negative_regulation MAP2K6 RARA 18445086 1921135 [MEK] inhibition *induces* caspases activation , differentiation blockade and degradation in acute promyelocytic leukaemia . Negative_regulation MAP2K6 RASA1 17646383 1793389 The downregulation of by Ras *required* the activation of the [Raf/MEK/extracellular] signal regulated kinase cascade and was correlated with the induction of mesenchymal morphology and migratory behavior . Negative_regulation MAP2K6 RELA 15073167 1257653 By contrast , cisplatin , either alone or with [MEK/ERK] *inhibitors* , induced little activation in antisense PP4 transfected cells . Negative_regulation MAP2K6 RELA 18176092 1883399 LTD ( 4 ) -induced MUC2 gene transcriptional activity was also suppressed by a G-protein inhibitor ( pertussis toxin ) , a protein kinase C ( PKC ) inhibitor ( bisindolylmaleimide ) , a mitogen activated protein/extracellular signal regulated kinase kinase ( [MEK] ) *inhibitor* ( PD98059 ) , an extracellular signal regulated kinase-2 ( ERK-2 ) inhibitor ( AG126 ) and a inhibitor . Negative_regulation MAP2K6 RELA 19823174 2187296 Sulfur dioxide donor significantly downregulated Raf-1 , [mitogen activated protein kinase kinase-1] ( MEK-1 ) and p-ERK/ERK , and *inhibited* pulmonary vascular smooth muscle cell proliferation , collagen remodeling and pulmonary vascular endothelial cell , and intercellular adhesion molecule 1 ( ICAM-1 ) expressions . Negative_regulation MAP2K6 RELA 20403072 2282171 [MEK/ERK] inhibition also *induced* I-kappaB phosphorylation and enhanced binding activity , leading to expression of cellular inhibitors of apoptosis protein 2 ( c-IAP2 ) , a known nuclear factor-kappaB (NF-kappaB) regulated endogenous anti-apoptotic molecule . Negative_regulation MAP2K6 RELA 9446561 483501 Inhibition of LPS mediated as well as LPS and ceramide mediated induction of iNOS and *activation* of by PD98059 , a specific inhibitor of activation of mitogen activated protein (MAP) kinase kinase ( [MEK] ) , and FPT inhibitor II , a selective inhibitor of Ras farnesyl protein transferase , indicate that the Ras-MAP kinase pathway is involved in LPS-ceramide induced activation of NF-kappaB and induction of iNOS , and that ceramide mediated signaling events probably converge into the LPS modulated MAP kinase signaling pathway resulting in greater activation of NF-kappaB and iNOS induction . Negative_regulation MAP2K6 ROCK1 12011049 962212 In normal rat kidney cells stably transformed by v-Src , we found that the chronic activation of [MEK] *induces* down-regulation of expression , thereby uncoupling Rho from stress fiber formation . Negative_regulation MAP2K6 ROCK1 21166955 2378690 Thus , it is suggested that the anti-angiogenic effect of HA1077 may be due to the combination of inhibition and [mitogen activated protein kinase kinase] ( MEK ) /ERK pathway *inhibition* . Negative_regulation MAP2K6 ROCK2 12011049 962213 In normal rat kidney cells stably transformed by v-Src , we found that the chronic activation of [MEK] *induces* down-regulation of expression , thereby uncoupling Rho from stress fiber formation . Negative_regulation MAP2K6 ROCK2 21166955 2378691 Thus , it is suggested that the anti-angiogenic effect of HA1077 may be due to the combination of inhibition and [mitogen activated protein kinase kinase] ( MEK ) /ERK pathway *inhibition* . Negative_regulation MAP2K6 RRM2B 19398949 2089505 Ribonucleotide reductase small subunit *suppresses* [MEK-ERK] activity by binding to ERK kinase 2 . Negative_regulation MAP2K6 S100B 21130124 2413998 Moreover , *reduces* myoblast apoptosis in an [MEK-ERK1/2] , Akt , JNK , and NF-?B dependent manner . Negative_regulation MAP2K6 SHC1 8033892 264153 We found that the expression of exogenous proteins *results* in an increased basal [MEK] ( MAPK/ERK activating kinase ) activity . Negative_regulation MAP2K6 SLC25A16 11707279 879535 Rho inhibitor ( exoenzyme C3 ) , Rho kinase inhibitor ( Y-27632 ) , myosin light chain kinase *inhibitor* ( ) , [MEK] inhibitor ( PD98059 ) and Src family tyrosine kinase inhibitor inhibited the Lf-enhanced collagen gel contraction . Negative_regulation MAP2K6 SMAD1 15019950 1221182 A reporter assay using NGF stimulated PC12 cells demonstrated that [MEK/Erk/Elk-driven] transcriptional activity was *inhibited* by and by PD98059 . Negative_regulation MAP2K6 SMAD5 15019950 1221183 A reporter assay using NGF stimulated PC12 cells demonstrated that [MEK/Erk/Elk-driven] transcriptional activity was *inhibited* by and by PD98059 . Negative_regulation MAP2K6 SNAP25 14668338 1210914 did not *inhibit* the kinase activities of MKK3 , [MKK6] , or p38 in vitro . Negative_regulation MAP2K6 SOD1 9582369 504220 In addition , *blocked* the TNF mediated activation of activated protein-1 , stress activated c-Jun protein kinase , and [mitogen activated protein kinase kinase] . Negative_regulation MAP2K6 SOD2 9582369 504221 In addition , *blocked* the TNF mediated activation of activated protein-1 , stress activated c-Jun protein kinase , and [mitogen activated protein kinase kinase] . Negative_regulation MAP2K6 SOD3 9582369 504222 In addition , *blocked* the TNF mediated activation of activated protein-1 , stress activated c-Jun protein kinase , and [mitogen activated protein kinase kinase] . Negative_regulation MAP2K6 STAT3 11591128 869431 To assess the relative importance of these pathways in promoting the survival of cytokine dependent neurons , we conditionally inactivated in mice and *inhibited* [MEK] , PI3K , and Akt in cultured neurons using pharmacological reagents and by expressing specific inhibitory proteins . Negative_regulation MAP2K6 STC1 19347030 2074456 STC1-/- cells had higher levels of activated [MEK] and ERK1/2 than their wild-type ( WT ) counterparts , and these levels were all *reduced* by stable expression of exogenous in STC1-/- cells . Negative_regulation MAP2K6 SYP 7677789 326406 The expression of dominant negative *blocked* the activation of [MEK] and raf-1 kinase in response to insulin and had no detectable effect on insulin induced activation of p21ras . Negative_regulation MAP2K6 TERF2 17646383 1793382 The downregulation of by Ras *required* the activation of the [Raf/MEK/extracellular] signal regulated kinase cascade and was correlated with the induction of mesenchymal morphology and migratory behavior . Negative_regulation MAP2K6 TERF2IP 17646383 1793384 The downregulation of by Ras *required* the activation of the [Raf/MEK/extracellular] signal regulated kinase cascade and was correlated with the induction of mesenchymal morphology and migratory behavior . Negative_regulation MAP2K6 THBS1 21453480 2417317 Inhibiting activity *reduced* the elevated activation of [MEK/ERK] and expression of key fibrogenic proteins . Negative_regulation MAP2K6 THBS1 21453480 2417325 also *blocked* platelet derived growth factor ( PDGF ) -induced contractile activity and [MEK/ERK] activation . Negative_regulation MAP2K6 TLN1 20220516 2237343 *prevented* epidermal growth factor induced phosphorylation of Raf-1 , [MEK] , and ERK1/2 . Negative_regulation MAP2K6 TLN1 20220516 2237377 As did not *inhibit* EGFR , Raf-1 , [MEK] or ERK1/2 kinase activities , the inhibitory effect of TLN-4601 on Ras signaling is not mediated by direct kinase inhibition . Negative_regulation MAP2K6 TMED7 15475007 1319150 For example , inhibitors of [MEK] and phosphatidylinositol-3-kinase *induced* expression primarily in G1 phase , while inhibitors of AKT activity stimulated these levels primarily in S phase . Negative_regulation MAP2K6 TMED7 23341544 2747461 Reduced ( 18 ) F-FLT PET reflected a modest , yet significant , reduction of Ki67 immunoreactivity , *inhibition* of [p-MEK] and p-ERK , and elevated tumor cell protein levels . Negative_regulation MAP2K6 UCN 16940414 1639237 The functional roles of Cdc2 and checkpoint kinase 1 (Chk1) in synergistic interactions between 7-hydroxystaurosporine ( ) and [mitogen activated protein kinase kinase] 1/2 ( MEK1/2 ) *inhibitors* [ e.g. , 2- ( 2-chloro-4-iodophenylamino ) -N-cyclopropylmethoxy-3,4-difluorobenzamide ( PD184352 ) ] were examined in human multiple myeloma cells in relation to MEK1/2/ERK1/2 activation and lethality . Negative_regulation MAP2K6 UGCG 10439045 635244 also abolished the activation of AP-1 induced by TNF and *inhibited* TNF induced activation of JNK and [mitogen activated protein kinase kinase] . Negative_regulation MAP2K6 VEGFA 16101130 1444157 R115777 +/- paclitaxel inhibited HDJ-2 farnesylation , up-regulated RhoB , transiently lowered ( P ) ERK/ERK and ( P ) Akt/Akt , reduced Raf-1 and [MEK] and *inhibited* secretion of and MMP-1 . Negative_regulation MAP2K6 VEGFA 16672338 1558644 By contrast , dependent ganglion cell suppression does not *require* [MEK-ERK] activation , but instead relies on VEGF stimulated HES1 activity , which is independent of NOTCH signaling . Negative_regulation MAP2K6 VEGFA 19509115 2098333 Western blot analysis revealed that K-Ras activation promoted the phosphorylation of [Raf/mitogen activated protein kinase kinase-1/2] ( MEK1/2 ) and expression of c-Jun. MEK1/2 inhibitors , U0126 and PD98059 , significantly *inhibited* the secretion of both CXC chemokines and , whereas the c-Jun NH ( 2 ) -terminal kinase inhibitor SP600125 abrogated only CXC chemokine production . Negative_regulation MAP2K6 WHSC1 21163924 2390758 Reexpression of MAF rescued cells from death induced by depletion , [MEK] *inhibition* , or FOS inactivation . Negative_regulation MAP2K6 XRCC5 17646383 1793383 The downregulation of by Ras *required* the activation of the [Raf/MEK/extracellular] signal regulated kinase cascade and was correlated with the induction of mesenchymal morphology and migratory behavior . Negative_regulation MAP2K6 XRCC6 17646383 1793386 The downregulation of by Ras *required* the activation of the [Raf/MEK/extracellular] signal regulated kinase cascade and was correlated with the induction of mesenchymal morphology and migratory behavior . Negative_regulation MAP2K6 YWHAB 12364324 1019104 GLP1 stimulated activation of Erk is blocked by inhibitors of [MEK] , but GLP1 does not *induce* the activation of A-Raf , , C-Raf , or Ras . Negative_regulation MAP2K6 ZGLP1 12364324 1019105 GLP1 stimulated activation of Erk is blocked by inhibitors of [MEK] , but does not *induce* the activation of A-Raf , B-Raf , C-Raf , or Ras . Negative_regulation MAP2K7 EPHB2 11230290 789245 VSMC migration in response to OA alone and with Ang II was also inhibited by N : -acetyl-cysteine , [MEK] *inhibition* , and antisense . Negative_regulation MAP2K7 EPHB2 12694865 1080934 U0126 , at concentrations consistent with inhibition of the isolated enzyme , *inhibited* phosphorylation , and therefore [MEK] activation , in response to each agonist . Negative_regulation MAP2K7 EPHB2 16237176 1470804 Consistent with a presynaptic function for endogenous H-ras/extracellular signal regulated kinase ( ERK ) signaling , we observed that , under normal physiologic conditions in wild-type mice , hippocampus dependent learning stimulated the ERK dependent phosphorylation of synapsin I , and [MEK] ( MAP kinase kinase ) *inhibition* selectively decreased the frequency of miniature EPSCs . Negative_regulation MAP2K7 EPHB2 20810616 2341731 We found that nanomolar concentrations of Sorafenib reduced the basal activity of , *inhibited* cAMP dependent activation of B-Raf and [MEK/ERK] signaling , and caused a concentration dependent inhibition of cell proliferation induced by cAMP , epidermal growth factor , or the combination of the two agonists . Negative_regulation MAP2K7 EPHB2 21166955 2378695 Thus , it is suggested that the anti-angiogenic effect of HA1077 may be due to the combination of ROCK inhibition and [mitogen activated protein kinase kinase] ( MEK ) pathway *inhibition* . Negative_regulation MAP2K7 FOXO1 17210752 1681621 Interestingly , overexpression of constitutively active also *led* to activation of [MEK] and Akt phosphorylation . Negative_regulation MAP2K7 MAP2K6 20503247 2289226 Expression of dominant negative forms of A-Raf , MKK4 or and pharmacological *inhibition* of [MEK] and p38 revealed that extracellular signal regulated protein kinase , p38 and c-Jun NH ( 2 ) -terminal protein kinase participate in the upregulation of AP-1 activity . Negative_regulation MAP2K7 MMP28 17566014 1792169 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K7 MMP7 17566014 1792184 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( [MEK] ) *inhibitor* , inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA . Negative_regulation MAP2K7 NEDD9 22435554 2573407 Binding to also *prevents* TPL-2 from phosphorylating [MEK] ( MAPK/ERK kinase ) , its downstream target . Negative_regulation MAP2K7 S100B 21130124 2413999 Moreover , *reduces* myoblast apoptosis in an [MEK-ERK1/2] , Akt , JNK , and NF-?B dependent manner . Negative_regulation MAP3K1 AXIN2 12878610 1142593 Expression of specific small interfering RNA against MEKK4 effectively attenuates JNK activation by the [MEKK1] binding-defective Axin mutant in 293T cells and *inhibits* JNK activation by wild-type in MEKK1-/- cells , confirming that MEKK4 is indeed another mitogen activated protein kinase kinase kinase that is specifically involved in Axin mediated JNK activation independently of MEKK1 . Negative_regulation MAP3K5 CHI3L1 15015934 1251095 The suppressive effects of were dependent on phosphoinositide 3-kinase activity , and treatment of cells with HC-gp39 *resulted* in AKT mediated serine/threonine phosphorylation of [apoptosis signal regulating kinase 1] . Negative_regulation MAP3K5 TFPI2 11689443 876250 The interaction between and ASK1 was induced by H ( 2 ) O ( 2 ) treatment and was *followed* by the decrease in [ASK1] activity . Negative_regulation MAP3K5 TFPI2 15218033 1281877 Down-regulation of activity by rapamycin coordinately *activated* [ASK1] , leading to elevated phosphorylation of c-Jun. Amino acid deprivation , which like rapamycin inhibits mTOR signaling , also inhibited PP5 activity , caused rapid dissociation of PR72 , and activated ASK1 signaling . Negative_regulation MAP3K5 TNF 15696199 1382724 In cultured ECs , reduction of TXNIP expression by small interfering RNA increased TRX binding to [ASK1] and *inhibited* activation of JNK/p38 and VCAM1 expression . Negative_regulation MAP3K5 TNNT2 12819028 1103859 Moreover , overexpression of constitutively active [ASK1] *induces* phosphorylation and inhibits shortening and calcium transient in adult cardiomyocytes . Negative_regulation MAP3K8 NEDD9 16448710 1534235 We show here that does not *inhibit* the intrinsic kinase activity of [Tpl2] . Negative_regulation MAP3K8 NEDD9 22435554 2573408 Binding to also *prevents* [TPL-2] from phosphorylating MEK ( MAPK/ERK kinase ) , its downstream target . Negative_regulation MAP4 EPHB2 24084092 2863431 LC3B-I ( [microtubule associated protein-1] *inhibitors* ) , LC3B-II , and phosphorylation of Akt or were measured with Western blot . Negative_regulation MAP6 EPHB2 24084092 2863436 LC3B-I ( [microtubule associated protein-1] *inhibitors* ) , LC3B-II , and phosphorylation of Akt or were measured with Western blot . Negative_regulation MAP7 EPHB2 24084092 2863441 LC3B-I ( [microtubule associated protein-1] *inhibitors* ) , LC3B-II , and phosphorylation of Akt or were measured with Western blot . Negative_regulation MAP9 EPHB2 24084092 2863416 LC3B-I ( [microtubule associated protein-1] *inhibitors* ) , LC3B-II , and phosphorylation of Akt or were measured with Western blot . Negative_regulation MAPK1 ANGPT1 24308939 2877789 The functional roles of DUSPs in *induced* regulation of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Negative_regulation MAPK1 ARSA 18563667 1952776 *inhibited* p38 [MAPK] but not ERK1/2 phosphorylation in washed platelets . Negative_regulation MAPK1 CCND1 19369047 2258042 We propose that breast cancer cell proliferation is inhibited by DHA through proteasome dependent degradation of ERalpha , reduced expression and *inhibition* of [MAPK] signaling . Negative_regulation MAPK1 CCND1 20113529 2213147 In contrast , focal adhesion/actin cytoskeleton , [MAPK] and NF B signaling appeared to characterize the target genes and their interacting proteins in *suppressed* PANC1 cells . Negative_regulation MAPK1 CCND1 23237355 2711148 Essential oil activated the caspase dependent apoptotic pathway , *induced* a rapid and transient activation of Akt and [Erk1/2] , and suppressed levels of expression in cultured pancreatic cancer cells . Negative_regulation MAPK1 EPHB2 11874466 918778 Further evidence for differential regulation of RAS and ERK is provided by the observations that TPO , which activates RAS but not protein kinase C , does not activate , and that the inhibitor of SRC kinases PP1 *inhibits* activation of RAS but not [ERK2] in response to thrombin . Negative_regulation MAPK1 EPHB2 15810889 1392162 Thus , [MAPK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation MAPK1 EPHB2 15910808 1412147 The [MAPK/extracellular] signal regulated protein kinase ( ) kinase *inhibitor* , PD098059 ( 2'-amino-3'-methoxyflavone ) , significantly inhibited basal tone in a dose dependent manner . Negative_regulation MAPK1 EPHB2 16291589 1526005 TCCM treatment activated p38 [mitogen activated protein kinase (MAPK)] and Janus kinase (JNK) but *inhibited* . Negative_regulation MAPK1 EPHB2 16291589 1526033 Thus , our results suggested that tumor induced p38 [MAPK] activation and *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation MAPK1 EPHB2 17615677 1769067 We conclude that activation and p38 [MAPK] *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation MAPK1 EPHB2 18048804 1882897 No significant effects on HO-1 induction were observed with the pretreatment of [mitogen activated protein kinase] pathway *inhibitors* PD98059 ( ) , SB203580 ( p38MAPK ) and JNKi , and conventional and atypical PKC inhibitors . Negative_regulation MAPK1 EPHB2 18567920 1952835 CypA induced nuclear factor kappaB (NF-kappaB) activity for MMP-9 transcription were strongly blocked by extracellular signal regulated kinase ( ) , c-Jun amino terminal kinase (JNK) inhibitors ( U0126 and SP600125 , respectively ) , but not by p38 [mitogen activated protein kinase (MAPK)] *inhibitors* ( SB203580 ) . Negative_regulation MAPK1 EPHB2 19180563 2049263 Activated *suppressed* p38 [MAPK] activation and Fas/FasL protein expression . Negative_regulation MAPK1 EPHB2 19428337 2077010 Histological examination of lung tissues revealed that [MAPK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation MAPK1 EPHB2 20226096 2230211 Furthermore , pretreatment by microinjection into the bilateral RVLM of a specific [ERK2] *inhibitor* , activation inhibitor peptide II ( 1 nmol ) ; Negative_regulation MAPK1 EPHB2 20881039 2347114 Extracellular signal regulated receptor kinase ( ) and p38 [mitogen activated protein kinase] *inhibitors* ( U0126 and SB203580 ) were sufficient to block Nup hyperphosphorylation in EMCV infected or L-expressing cells . Negative_regulation MAPK1 EPHB2 21323644 2447767 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) signalling . Negative_regulation MAPK1 EPHB2 21663947 2459756 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation MAPK1 EPHB2 22129743 2515089 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 [mitogen activated protein kinase (MAPK)] and Akt phosphorylation , but in contrast , *inhibited* that of ( 1/2 ) . Negative_regulation MAPK1 EPHB2 22521802 2630849 Overexpression of the signaling protein Smad3 *enhanced* TGF-ß induced activation of ERK [MAPK] , whereas inhibition of Smad3 with a siRNA blocked MAPK phosphorylation in response to TGF-ß . Negative_regulation MAPK1 F2R 20215560 2259579 Both receptors stimulated extracellular signal regulated kinase ( [ERK) 1/2] phosphorylation , but only *inhibited* adenylyl cyclase activity , and pertussis toxin blocked PAR1 effects on both adenylyl cyclase and ERK1/2 signaling . Negative_regulation MAPK1 FAS 15669079 1382141 Concurrently , blockade drastically *activated* [MAPK] and promoted further a prominent accumulation of HIF-1alpha in Her-2/neu overexpressors . Negative_regulation MAPK1 FAS 8846779 338009 cross linking *resulted* also in [ERK-2] activation and in phospholipase A2 (PLA2) induction , independently of the PC-PLC/aSMase pathway . Negative_regulation MAPK1 FHL1 23456229 2781797 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Negative_regulation MAPK1 FUT4 20506505 2307907 Results show that overexpression of *increases* the phosphorylation of ERK1/2 , p38 [MAPK] , and PI3K/Akt . Negative_regulation MAPK1 HBEGF 19048624 2023699 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked [MAPK] signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 MAPK , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Negative_regulation MAPK1 HBEGF 19919524 2166798 Western blot analysis showed *prevents* ethanol from altering [MAPK] phosphorylation . Negative_regulation MAPK1 IL1B 12388337 1031317 CO treatment inhibited induced ERK1/2 activation but did not *inhibit* JNK and p38 [MAPK] . Negative_regulation MAPK1 IL1B 16718462 1584859 A synthetic peptide , C3d , reported to bind NCAM , did not activate [MAPK] or Akt as reported in neurons but *inhibited* induced MAPK activity , thereby mimicking the effect of SU5402 . Negative_regulation MAPK1 IL1B 18669445 1973088 DPML significantly inhibited tumor necrosis factor alpha , , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 [mitogen activated protein kinase] activation in the lung . Negative_regulation MAPK1 IL1B 19214751 2071799 triggered the activation of p38 and ERK1/2 ( p44/42) MAP kinase (MAPK) signaling pathways , but WIN55,212-2 mainly *inhibited* p38 [MAPK] phosphorylation . Negative_regulation MAPK1 LBP 19010986 2029056 and sCD14 *inhibited* the nontypeable Haemophilus influenzae ( NTHi ) -dependent secretion of IL-8 and the activation of NF-kappaB and p38 [mitogen activated protein kinase] signalling pathways but they increased the internalisation of NTHi by airway epithelial cells . Negative_regulation MAPK1 MAP2K6 11237743 790196 The [MAPK] kinase ( ) *inhibitor* , PD98059 , blocked GSA stimulated MAPK activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Negative_regulation MAPK1 MAP2K6 11258898 795477 T ( 4 ) -induced nuclear complexing of p53 and MAPK was inhibited by PD 98059 ( PD ) and U0126 , two [MAPK] kinase ( ) *inhibitors* , and was absent in cells treated with MEK antisense oligonucleotide and in dominant negative Ras cells . Negative_regulation MAPK1 MAP2K6 11304531 826782 The activation of p38 [MAPK] by Galpha ( q ) and Gbetagamma was *blocked* by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Negative_regulation MAPK1 MAP2K6 11399487 824120 The role of MAPK activation on GPalpha , FSHbeta and LHbeta gene expression was determined by administration of [MAPK-kinase] ( ) *inhibitor* ( PD98059 ; Negative_regulation MAPK1 MAP2K6 11744690 915747 Furthermore , the activation of p38 [MAPK] caused by overexpressing active RasVHa could not be inhibited using dominant negative mutants of MyD88 , IRAK , or IRAK-2 , or TRAF6 , but could be *inhibited* by dominant negative MKK3 or . Negative_regulation MAPK1 MAP2K6 11787422 891818 Indeed the [MAPK] kinase ( = ) *inhibitor* PD98059 inhibits the activation of parasite MAPK , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Negative_regulation MAPK1 MAP2K6 12649265 1080035 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant or p38beta2 MAPK *inhibited* interleukin-1beta induced p38 [MAPK] activation , COX-2 gene expression , and PGE2 release . Negative_regulation MAPK1 MAP2K6 12738672 1119513 Blocking the *activation* of p44/42 [mitogen activated protein kinase (MAPK)] by the specific mitogen induced extracellular kinase ( ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAPK1 MAP2K6 15284289 1277899 In contrast , a [mitogen activated protein (MAP) kinase/extracellular] signal regulated kinase ( ERK ) kinase ( ) /ERK *inhibitor* , PD98059 , completely abrogated the effect of high glucose . Negative_regulation MAPK1 MAP2K6 15737734 1378663 Axons protected by MG132 displayed persistent phosphorylation of [Erk1/2] , and pharmacological inhibition of activity with U0126 ( 50 microM ) *restored* rapid axonal degeneration . Negative_regulation MAPK1 MAP2K6 18176092 1883408 LTD ( 4 ) -induced MUC2 gene transcriptional activity was also suppressed by a G-protein *inhibitor* ( pertussis toxin ) , a protein kinase C ( PKC ) inhibitor ( bisindolylmaleimide ) , a mitogen activated protein/extracellular signal regulated kinase kinase ( ) inhibitor ( PD98059 ) , an [extracellular signal regulated kinase-2] ( ERK-2 ) inhibitor ( AG126 ) and a nuclear factor kappaB (NF-kappaB) inhibitor . Negative_regulation MAPK1 MAP2K6 19606165 2105684 Overexpression of , a kinase upstream of p38 MAPK , *increased* phosphorylation of p38 [MAPK] and attenuated t-BOOH induced ARPE-19 cell death by 16 % . Negative_regulation MAPK1 MAP2K6 19915797 2197769 We confirmed the interaction between phospho-p38 and MAP4 using immunoprecipitation and found that SB203580 , a [p38/MAPK] *inhibitor* , increases and ( Glu ) overexpression decreases hypoxic cell viability . Negative_regulation MAPK1 MAP2K6 21323644 2447773 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAPK1 MAP2K6 22920673 2710171 We next analysed the effects of inhibiting signalling downstream of Ras , by specific *inhibitors* of [p38MAPK] , PI3-K or , on reoviral killing examined by MTT assay . Negative_regulation MAPK1 MAP2K6 23174698 2735944 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . inhibitor , U0126 completely blocked PKA inhibition *induced* [MAPK] activation and GVBD . Negative_regulation MAPK1 MAP2K6 9144515 429643 In the *presence* of the inhibitor , PD 098059 , phagocytosis was reduced by approximately 50 % , while ERK1 and [ERK2] activity was reduced by 85 to 90 % . Negative_regulation MAPK1 MAP2K6 9582373 504239 However , elevated activity *attenuated* subsequent stimulation of Erk1 and [Erk2] by serum . Negative_regulation MAPK1 MUC16 22977714 2674032 Rottlerin ( PKCd inhibitor ) inhibited PMA induced expression , and also *inhibited* the phosphorylation of activated p38 [MAPK] by PMA . Negative_regulation MAPK1 NES 15269220 1296108 Finally , we demonstrate that the ability of MKP-3 to cause the cytoplasmic retention of [ERK2] *requires* both a functional kinase interaction motif and . Negative_regulation MAPK1 PECAM1 19096001 2036121 These findings reveal that [p38MAPK] phosphorylation and platelet activation by LDL are *suppressed* by two mechanisms : ( 1 ) short activation of , and ( 2 ) prolonged activation of SHP-1 and SHP-2 . Negative_regulation MAPK1 PLAU 11606583 888438 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 [MAPK] and *inhibited* cell associated expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation MAPK1 PLAU 23615713 2804730 In addition , avß6 integrin *induced* the phosphorylation of p38 [MAPK] and PI3 K/Akt , contributing to the up-regulation of uPA , as treatment with the specific inhibitor for p38 mitogen activated protein kinases (MAPK) ( SB203580 ) or phosphatidylinositol 3-kinase (PI3 K)/Akt ( LY294002 ) strikingly abrogated expression . Negative_regulation MAPK1 RASD1 11751935 921984 Expression of alone *resulted* in a 1.9- to 4.9-fold increase in [HA-Erk-2] activity ; Negative_regulation MAPK1 RASD1 15913563 1412592 however , *blocked* acute D ( 2L ) receptor mediated activation of [ERK 1/2] by approximately 50 % . Negative_regulation MAPK1 RGS16 11602604 888199 These data suggest that tyrosine phosphorylation regulates RGS16 function and that EGFR may potentially *inhibit* Galpha ( i ) -dependent [MAPK] activation in a feedback loop by enhancing activity through tyrosine phosphorylation . Negative_regulation MAPK1 S100B 19961838 2199380 Albumin activated ERK1/2 , p38 [MAPK] and JNK signaling pathways in astrocytes , and *induced* the production of interleukin (IL)-1beta , inducible nitric oxide (NO) synthase , the NO metabolite nitrite , and the chemokine CX3CL1 while reducing the level of . Negative_regulation MAPK1 SPHK1 22684547 2705918 increased the constitutive expression of extracellular signal regulated kinase1/2 ( ERK1/2 ) but *reduced* the constitutive expression of p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK1 TCN1 23018889 2720278 Furthermore , whereas Compound C ( an AMPK inhibitor ) , AMPK-DN ( AMPK-dominant negative ) mutant , and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA *inhibited* the 8-Cl-cAMP- and AICAR mediated phosphorylation of AMPK and p38 [MAPK] . Negative_regulation MAPK1 TLR7 18287072 1872504 However , when coupled with Sema6D , a ligand for Plexin-A1 , limited *resulted* in PDC-TREM mediated DAP12 dependent phosphorylation of phosphoinositide 3-kinase (PI3K) and [extracellular regulated kinase (Erk) 1/2] at 6-9 h , and IFN-alpha was produced . Negative_regulation MAPK1 TNF 10657669 664213 When KC was instilled as a proinflammatory stimulus , neutrophil accumulation was significantly decreased by p38 [MAPK] *inhibition* independent of or LPS . Negative_regulation MAPK1 TNF 12297293 991241 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Negative_regulation MAPK1 TNF 14729457 1198458 Among other cellular responses , *induces* different forms of cell death and the activation of the p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK1 TNF 15015934 1251068 Stimulation of human skin fibroblasts or articular chondrocytes with IL-1 or in the presence of HC-gp39 *resulted* in a marked reduction of both p38 [mitogen activated protein kinase] and stress activated protein kinase/Jun N-terminal kinase phosphorylation , whereas nuclear translocation of nuclear factor kappaB proceeded unimpeded . Negative_regulation MAPK1 TNF 15519192 1328833 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial TNFalpha mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 [MAPK] activation . Negative_regulation MAPK1 TNF 15763380 1383451 Furthermore , pretreatment with oxymatrine significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet-to-dry weight ratio , decreases in serum level and *inhibition* of phosphorylated p38 [MAPK] . Negative_regulation MAPK1 TNF 15952594 1421639 Pretreatment of EGCG significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet to dry weight ratio , decreased of level in serum and *inhibition* of phosphorylation of p38 [MAPK] . Negative_regulation MAPK1 TNF 17189827 1680101 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Negative_regulation MAPK1 TNF 17214640 1681810 Roxithromycin significantly inhibited induced c-Jun N-terminal kinase activation ( JNP ) and marginally *inhibited* extracellular signal regulated kinase ( ERK ) 1/2 activation , but not p38 [mitogen activated protein kinase] activation . Negative_regulation MAPK1 TNF 17438131 1742708 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Negative_regulation MAPK1 TNF 19086324 2000270 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 [MAPK] and NF-kappaB activities , and then overexpression , thus alleviating the inflammatory reaction . Negative_regulation MAPK1 TNF 19118509 2004835 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and and *inhibited* the phosphorylation of Akt , PKCdelta and p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK1 TNF 19450605 2096914 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 [MAPK] and *inhibited* cardiac expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation MAPK1 TNF 21147093 2378281 LPS induced phosphorylation of I?Ba and p38 [MAPK] was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation MAPK1 TNF 23056531 2685394 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit a ( TNF-a production in cultured macrophages ) and in vitro [MAPK] p38a *inhibition* . Negative_regulation MAPK1 TNF 23066265 2685763 Doxycycline , nonsteroidal anti-inflammatory drugs ( NSAIDs ) , bisphosphonates , nitrous oxide ( NO ) synthase inhibitors , recombinant human interleukin-11 ( rhIL-11 ) , omega-3 fatty acid , mouse anti-human interleukin-6 receptor antibody ( MRA ) , [mitogen activated protein kinase (MAPK)] *inhibitors* , nuclear factor-kappa B (NF-kb) inhibitors , osteoprotegerin , and tumor necrosis factor antagonist ( ) are some of the therapeutic agents that have host modulation properties . Negative_regulation MAPK1 TNF 23518420 2777197 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and protein expression in the kidney , as well as *inhibiting* [p38MAPK] signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation MAPK1 TNF 24152910 2875242 It was found that thrombin down-regulates the HMGB1 mediated induction of both and IL-6 and *inhibits* the activation of both p38 [MAPK] and NF-?B in HUVECs pretreated with PC . Negative_regulation MAPK1 TNF 8665940 368983 Low concentrations ( 2 nM ) of okadaic acid , a serine/threonine phosphatase inhibitor , prevented induced *inhibition* of [MAPK] and restored insulin 's effect on MAPK activity , while orthovanadate ( a tyrosine phosphatase inhibitor ) , inhibitor 2 ( phosphatase-1 inhibitor ) and FK506 ( phosphatase-2B inhibitor ) were ineffective . Negative_regulation MAPK10 ANGPT1 24308939 2877790 The functional roles of DUSPs in *induced* regulation of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Negative_regulation MAPK10 ARSA 18563667 1952777 *inhibited* p38 [MAPK] but not ERK1/2 phosphorylation in washed platelets . Negative_regulation MAPK10 CCND1 19369047 2258043 We propose that breast cancer cell proliferation is inhibited by DHA through proteasome dependent degradation of ERalpha , reduced expression and *inhibition* of [MAPK] signaling . Negative_regulation MAPK10 CCND1 20113529 2213148 In contrast , focal adhesion/actin cytoskeleton , [MAPK] and NF B signaling appeared to characterize the target genes and their interacting proteins in *suppressed* PANC1 cells . Negative_regulation MAPK10 EPHB2 15810889 1392163 Thus , [MAPK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation MAPK10 EPHB2 15910808 1412148 The [MAPK/extracellular] signal regulated protein kinase ( ) kinase *inhibitor* , PD098059 ( 2'-amino-3'-methoxyflavone ) , significantly inhibited basal tone in a dose dependent manner . Negative_regulation MAPK10 EPHB2 16291589 1526006 TCCM treatment activated p38 [mitogen activated protein kinase (MAPK)] and Janus kinase (JNK) but *inhibited* . Negative_regulation MAPK10 EPHB2 16291589 1526034 Thus , our results suggested that tumor induced p38 [MAPK] activation and *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation MAPK10 EPHB2 17615677 1769069 We conclude that activation and p38 [MAPK] *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation MAPK10 EPHB2 18048804 1882898 No significant effects on HO-1 induction were observed with the pretreatment of [mitogen activated protein kinase] pathway *inhibitors* PD98059 ( ) , SB203580 ( p38MAPK ) and JNKi , and conventional and atypical PKC inhibitors . Negative_regulation MAPK10 EPHB2 18567920 1952836 CypA induced nuclear factor kappaB (NF-kappaB) activity for MMP-9 transcription were strongly blocked by extracellular signal regulated kinase ( ) , c-Jun amino terminal kinase (JNK) inhibitors ( U0126 and SP600125 , respectively ) , but not by p38 [mitogen activated protein kinase (MAPK)] *inhibitors* ( SB203580 ) . Negative_regulation MAPK10 EPHB2 19180563 2049264 Activated *suppressed* p38 [MAPK] activation and Fas/FasL protein expression . Negative_regulation MAPK10 EPHB2 19428337 2077011 Histological examination of lung tissues revealed that [MAPK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation MAPK10 EPHB2 20881039 2347115 Extracellular signal regulated receptor kinase ( ) and p38 [mitogen activated protein kinase] *inhibitors* ( U0126 and SB203580 ) were sufficient to block Nup hyperphosphorylation in EMCV infected or L-expressing cells . Negative_regulation MAPK10 EPHB2 21323644 2447775 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) signalling . Negative_regulation MAPK10 EPHB2 21663947 2459759 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation MAPK10 EPHB2 22129743 2515090 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 [mitogen activated protein kinase (MAPK)] and Akt phosphorylation , but in contrast , *inhibited* that of ( 1/2 ) . Negative_regulation MAPK10 EPHB2 22521802 2630851 Overexpression of the signaling protein Smad3 *enhanced* TGF-ß induced activation of ERK [MAPK] , whereas inhibition of Smad3 with a siRNA blocked MAPK phosphorylation in response to TGF-ß . Negative_regulation MAPK10 FAS 15669079 1382142 Concurrently , blockade drastically *activated* [MAPK] and promoted further a prominent accumulation of HIF-1alpha in Her-2/neu overexpressors . Negative_regulation MAPK10 FHL1 23456229 2781798 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Negative_regulation MAPK10 FUT4 20506505 2307908 Results show that overexpression of *increases* the phosphorylation of ERK1/2 , p38 [MAPK] , and PI3K/Akt . Negative_regulation MAPK10 HBEGF 19048624 2023700 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked MAPK signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 [MAPK] , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Negative_regulation MAPK10 HBEGF 19919524 2166799 Western blot analysis showed *prevents* ethanol from altering [MAPK] phosphorylation . Negative_regulation MAPK10 IL1B 12388337 1031319 CO treatment inhibited induced ERK1/2 activation but did not *inhibit* JNK and p38 [MAPK] . Negative_regulation MAPK10 IL1B 16718462 1584863 A synthetic peptide , C3d , reported to bind NCAM , did not activate [MAPK] or Akt as reported in neurons but *inhibited* induced MAPK activity , thereby mimicking the effect of SU5402 . Negative_regulation MAPK10 IL1B 18669445 1973090 DPML significantly inhibited tumor necrosis factor alpha , , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 [mitogen activated protein kinase] activation in the lung . Negative_regulation MAPK10 IL1B 19214751 2071802 triggered the activation of p38 and ERK1/2 ( p44/42) MAP kinase (MAPK) signaling pathways , but WIN55,212-2 mainly *inhibited* p38 [MAPK] phosphorylation . Negative_regulation MAPK10 LBP 19010986 2029057 and sCD14 *inhibited* the nontypeable Haemophilus influenzae ( NTHi ) -dependent secretion of IL-8 and the activation of NF-kappaB and p38 [mitogen activated protein kinase] signalling pathways but they increased the internalisation of NTHi by airway epithelial cells . Negative_regulation MAPK10 MAP2K6 11237743 790203 The [MAPK] kinase ( ) *inhibitor* , PD98059 , blocked GSA stimulated MAPK activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Negative_regulation MAPK10 MAP2K6 11258898 795484 T ( 4 ) -induced nuclear complexing of p53 and MAPK was inhibited by PD 98059 ( PD ) and U0126 , two [MAPK] kinase ( ) *inhibitors* , and was absent in cells treated with MEK antisense oligonucleotide and in dominant negative Ras cells . Negative_regulation MAPK10 MAP2K6 11304531 826785 The activation of p38 [MAPK] by Galpha ( q ) and Gbetagamma was *blocked* by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Negative_regulation MAPK10 MAP2K6 11399487 824127 The role of MAPK activation on GPalpha , FSHbeta and LHbeta gene expression was determined by administration of [MAPK-kinase] ( ) *inhibitor* ( PD98059 ; Negative_regulation MAPK10 MAP2K6 11744690 915749 Furthermore , the activation of p38 [MAPK] caused by overexpressing active RasVHa could not be inhibited using dominant negative mutants of MyD88 , IRAK , or IRAK-2 , or TRAF6 , but could be *inhibited* by dominant negative MKK3 or . Negative_regulation MAPK10 MAP2K6 11787422 891825 Indeed the [MAPK] kinase ( = ) *inhibitor* PD98059 inhibits the activation of parasite MAPK , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Negative_regulation MAPK10 MAP2K6 12649265 1080036 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant or p38beta2 MAPK *inhibited* interleukin-1beta induced p38 [MAPK] activation , COX-2 gene expression , and PGE2 release . Negative_regulation MAPK10 MAP2K6 12738672 1119520 Blocking the *activation* of p44/42 [mitogen activated protein kinase (MAPK)] by the specific mitogen induced extracellular kinase ( ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAPK10 MAP2K6 15284289 1277906 In contrast , a [mitogen activated protein (MAP) kinase/extracellular] signal regulated kinase ( ERK ) kinase ( ) /ERK *inhibitor* , PD98059 , completely abrogated the effect of high glucose . Negative_regulation MAPK10 MAP2K6 19606165 2105685 Overexpression of , a kinase upstream of p38 MAPK , *increased* phosphorylation of p38 [MAPK] and attenuated t-BOOH induced ARPE-19 cell death by 16 % . Negative_regulation MAPK10 MAP2K6 19915797 2197770 We confirmed the interaction between phospho-p38 and MAP4 using immunoprecipitation and found that SB203580 , a [p38/MAPK] *inhibitor* , increases and ( Glu ) overexpression decreases hypoxic cell viability . Negative_regulation MAPK10 MAP2K6 21323644 2447781 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAPK10 MAP2K6 22920673 2710180 We next analysed the effects of inhibiting signalling downstream of Ras , by specific *inhibitors* of [p38MAPK] , PI3-K or , on reoviral killing examined by MTT assay . Negative_regulation MAPK10 MAP2K6 23174698 2735951 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . inhibitor , U0126 completely blocked PKA inhibition *induced* [MAPK] activation and GVBD . Negative_regulation MAPK10 MUC16 22977714 2674033 Rottlerin ( PKCd inhibitor ) inhibited PMA induced expression , and also *inhibited* the phosphorylation of activated p38 [MAPK] by PMA . Negative_regulation MAPK10 PECAM1 19096001 2036127 These findings reveal that [p38MAPK] phosphorylation and platelet activation by LDL are *suppressed* by two mechanisms : ( 1 ) short activation of , and ( 2 ) prolonged activation of SHP-1 and SHP-2 . Negative_regulation MAPK10 PLAU 11606583 888439 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 [MAPK] and *inhibited* cell associated expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation MAPK10 PLAU 23615713 2804731 In addition , avß6 integrin *induced* the phosphorylation of p38 [MAPK] and PI3 K/Akt , contributing to the up-regulation of uPA , as treatment with the specific inhibitor for p38 mitogen activated protein kinases (MAPK) ( SB203580 ) or phosphatidylinositol 3-kinase (PI3 K)/Akt ( LY294002 ) strikingly abrogated expression . Negative_regulation MAPK10 RGS16 11602604 888201 These data suggest that tyrosine phosphorylation regulates RGS16 function and that EGFR may potentially *inhibit* Galpha ( i ) -dependent [MAPK] activation in a feedback loop by enhancing activity through tyrosine phosphorylation . Negative_regulation MAPK10 S100B 19961838 2199381 Albumin activated ERK1/2 , p38 [MAPK] and JNK signaling pathways in astrocytes , and *induced* the production of interleukin (IL)-1beta , inducible nitric oxide (NO) synthase , the NO metabolite nitrite , and the chemokine CX3CL1 while reducing the level of . Negative_regulation MAPK10 SPHK1 22684547 2705919 increased the constitutive expression of extracellular signal regulated kinase1/2 ( ERK1/2 ) but *reduced* the constitutive expression of p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK10 TCN1 23018889 2720286 Furthermore , whereas Compound C ( an AMPK inhibitor ) , AMPK-DN ( AMPK-dominant negative ) mutant , and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA *inhibited* the 8-Cl-cAMP- and AICAR mediated phosphorylation of AMPK and p38 [MAPK] . Negative_regulation MAPK10 TNF 10657669 664215 When KC was instilled as a proinflammatory stimulus , neutrophil accumulation was significantly decreased by p38 [MAPK] *inhibition* independent of or LPS . Negative_regulation MAPK10 TNF 12297293 991242 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Negative_regulation MAPK10 TNF 14729457 1198459 Among other cellular responses , *induces* different forms of cell death and the activation of the p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK10 TNF 15015934 1251070 Stimulation of human skin fibroblasts or articular chondrocytes with IL-1 or in the presence of HC-gp39 *resulted* in a marked reduction of both p38 [mitogen activated protein kinase] and stress activated protein kinase/Jun N-terminal kinase phosphorylation , whereas nuclear translocation of nuclear factor kappaB proceeded unimpeded . Negative_regulation MAPK10 TNF 15519192 1328834 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as TNFalpha production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 [MAPK] activation . Negative_regulation MAPK10 TNF 15763380 1383452 Furthermore , pretreatment with oxymatrine significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet-to-dry weight ratio , decreases in serum level and *inhibition* of phosphorylated p38 [MAPK] . Negative_regulation MAPK10 TNF 15952594 1421640 Pretreatment of EGCG significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet to dry weight ratio , decreased of level in serum and *inhibition* of phosphorylation of p38 [MAPK] . Negative_regulation MAPK10 TNF 17189827 1680103 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Negative_regulation MAPK10 TNF 17214640 1681812 Roxithromycin significantly inhibited induced c-Jun N-terminal kinase activation ( JNP ) and marginally *inhibited* extracellular signal regulated kinase ( ERK ) 1/2 activation , but not p38 [mitogen activated protein kinase] activation . Negative_regulation MAPK10 TNF 17438131 1742709 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Negative_regulation MAPK10 TNF 19086324 2000271 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 [MAPK] and NF-kappaB activities , and then overexpression , thus alleviating the inflammatory reaction . Negative_regulation MAPK10 TNF 19118509 2004838 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and and *inhibited* the phosphorylation of Akt , PKCdelta and p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK10 TNF 19450605 2096915 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 [MAPK] and *inhibited* cardiac expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation MAPK10 TNF 21147093 2378284 LPS induced phosphorylation of I?Ba and p38 [MAPK] was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation MAPK10 TNF 23056531 2685396 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit a ( TNF-a production in cultured macrophages ) and in vitro [MAPK] p38a *inhibition* . Negative_regulation MAPK10 TNF 23066265 2685764 Doxycycline , nonsteroidal anti-inflammatory drugs ( NSAIDs ) , bisphosphonates , nitrous oxide ( NO ) synthase inhibitors , recombinant human interleukin-11 ( rhIL-11 ) , omega-3 fatty acid , mouse anti-human interleukin-6 receptor antibody ( MRA ) , [mitogen activated protein kinase (MAPK)] *inhibitors* , nuclear factor-kappa B (NF-kb) inhibitors , osteoprotegerin , and tumor necrosis factor antagonist ( ) are some of the therapeutic agents that have host modulation properties . Negative_regulation MAPK10 TNF 23518420 2777198 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and protein expression in the kidney , as well as *inhibiting* [p38MAPK] signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation MAPK10 TNF 24152910 2875245 It was found that thrombin down-regulates the HMGB1 mediated induction of both and IL-6 and *inhibits* the activation of both p38 [MAPK] and NF-?B in HUVECs pretreated with PC . Negative_regulation MAPK10 TNF 8665940 368984 Low concentrations ( 2 nM ) of okadaic acid , a serine/threonine phosphatase inhibitor , prevented *induced* inhibition of [MAPK] and restored insulin 's effect on MAPK activity , while orthovanadate ( a tyrosine phosphatase inhibitor ) , inhibitor 2 ( phosphatase-1 inhibitor ) and FK506 ( phosphatase-2B inhibitor ) were ineffective . Negative_regulation MAPK11 ANGPT1 24308939 2877791 The functional roles of DUSPs in *induced* regulation of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Negative_regulation MAPK11 ARSA 18563667 1952778 *inhibited* p38 [MAPK] but not ERK1/2 phosphorylation in washed platelets . Negative_regulation MAPK11 CCND1 19369047 2258044 We propose that breast cancer cell proliferation is inhibited by DHA through proteasome dependent degradation of ERalpha , reduced expression and *inhibition* of [MAPK] signaling . Negative_regulation MAPK11 CCND1 20113529 2213149 In contrast , focal adhesion/actin cytoskeleton , [MAPK] and NF B signaling appeared to characterize the target genes and their interacting proteins in *suppressed* PANC1 cells . Negative_regulation MAPK11 EPHB2 15810889 1392164 Thus , [MAPK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation MAPK11 EPHB2 15910808 1412149 The [MAPK/extracellular] signal regulated protein kinase ( ) kinase *inhibitor* , PD098059 ( 2'-amino-3'-methoxyflavone ) , significantly inhibited basal tone in a dose dependent manner . Negative_regulation MAPK11 EPHB2 16291589 1526007 TCCM treatment activated p38 [mitogen activated protein kinase (MAPK)] and Janus kinase (JNK) but *inhibited* . Negative_regulation MAPK11 EPHB2 16291589 1526035 Thus , our results suggested that tumor induced p38 [MAPK] activation and *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation MAPK11 EPHB2 17615677 1769071 We conclude that activation and p38 [MAPK] *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation MAPK11 EPHB2 18048804 1882899 No significant effects on HO-1 induction were observed with the pretreatment of [mitogen activated protein kinase] pathway *inhibitors* PD98059 ( ) , SB203580 ( p38MAPK ) and JNKi , and conventional and atypical PKC inhibitors . Negative_regulation MAPK11 EPHB2 18567920 1952837 CypA induced nuclear factor kappaB (NF-kappaB) activity for MMP-9 transcription were strongly blocked by extracellular signal regulated kinase ( ) , c-Jun amino terminal kinase (JNK) inhibitors ( U0126 and SP600125 , respectively ) , but not by p38 [mitogen activated protein kinase (MAPK)] *inhibitors* ( SB203580 ) . Negative_regulation MAPK11 EPHB2 19180563 2049265 Activated *suppressed* p38 [MAPK] activation and Fas/FasL protein expression . Negative_regulation MAPK11 EPHB2 19428337 2077012 Histological examination of lung tissues revealed that [MAPK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation MAPK11 EPHB2 20881039 2347116 Extracellular signal regulated receptor kinase ( ) and p38 [mitogen activated protein kinase] *inhibitors* ( U0126 and SB203580 ) were sufficient to block Nup hyperphosphorylation in EMCV infected or L-expressing cells . Negative_regulation MAPK11 EPHB2 21323644 2447783 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) signalling . Negative_regulation MAPK11 EPHB2 21663947 2459762 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation MAPK11 EPHB2 22129743 2515091 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 [mitogen activated protein kinase (MAPK)] and Akt phosphorylation , but in contrast , *inhibited* that of ( 1/2 ) . Negative_regulation MAPK11 EPHB2 22521802 2630853 Overexpression of the signaling protein Smad3 *enhanced* TGF-ß induced activation of ERK [MAPK] , whereas inhibition of Smad3 with a siRNA blocked MAPK phosphorylation in response to TGF-ß . Negative_regulation MAPK11 FAS 15669079 1382143 Concurrently , blockade drastically *activated* [MAPK] and promoted further a prominent accumulation of HIF-1alpha in Her-2/neu overexpressors . Negative_regulation MAPK11 FHL1 23456229 2781799 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Negative_regulation MAPK11 FUT4 20506505 2307909 Results show that overexpression of *increases* the phosphorylation of ERK1/2 , p38 [MAPK] , and PI3K/Akt . Negative_regulation MAPK11 HBEGF 19048624 2023701 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked [MAPK] signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 MAPK , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Negative_regulation MAPK11 HBEGF 19919524 2166800 Western blot analysis showed *prevents* ethanol from altering [MAPK] phosphorylation . Negative_regulation MAPK11 IL1B 12388337 1031321 CO treatment inhibited induced ERK1/2 activation but did not *inhibit* JNK and p38 [MAPK] . Negative_regulation MAPK11 IL1B 16718462 1584867 A synthetic peptide , C3d , reported to bind NCAM , did not activate [MAPK] or Akt as reported in neurons but *inhibited* induced MAPK activity , thereby mimicking the effect of SU5402 . Negative_regulation MAPK11 IL1B 18669445 1973092 DPML significantly inhibited tumor necrosis factor alpha , , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 [mitogen activated protein kinase] activation in the lung . Negative_regulation MAPK11 IL1B 19214751 2071805 triggered the activation of p38 and ERK1/2 ( p44/42) MAP kinase (MAPK) signaling pathways , but WIN55,212-2 mainly *inhibited* p38 [MAPK] phosphorylation . Negative_regulation MAPK11 LBP 19010986 2029058 and sCD14 *inhibited* the nontypeable Haemophilus influenzae ( NTHi ) -dependent secretion of IL-8 and the activation of NF-kappaB and p38 [mitogen activated protein kinase] signalling pathways but they increased the internalisation of NTHi by airway epithelial cells . Negative_regulation MAPK11 MAP2K6 11237743 790210 The [MAPK] kinase ( ) *inhibitor* , PD98059 , blocked GSA stimulated MAPK activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Negative_regulation MAPK11 MAP2K6 11258898 795491 T ( 4 ) -induced nuclear complexing of p53 and MAPK was inhibited by PD 98059 ( PD ) and U0126 , two [MAPK] kinase ( ) *inhibitors* , and was absent in cells treated with MEK antisense oligonucleotide and in dominant negative Ras cells . Negative_regulation MAPK11 MAP2K6 11304531 826788 The activation of p38 [MAPK] by Galpha ( q ) and Gbetagamma was *blocked* by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Negative_regulation MAPK11 MAP2K6 11399487 824134 The role of MAPK activation on GPalpha , FSHbeta and LHbeta gene expression was determined by administration of [MAPK-kinase] ( ) *inhibitor* ( PD98059 ; Negative_regulation MAPK11 MAP2K6 11744690 915751 Furthermore , the activation of p38 [MAPK] caused by overexpressing active RasVHa could not be inhibited using dominant negative mutants of MyD88 , IRAK , or IRAK-2 , or TRAF6 , but could be *inhibited* by dominant negative MKK3 or . Negative_regulation MAPK11 MAP2K6 11787422 891832 Indeed the [MAPK] kinase ( = ) *inhibitor* PD98059 inhibits the activation of parasite MAPK , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Negative_regulation MAPK11 MAP2K6 12649265 1080037 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant or p38beta2 MAPK *inhibited* interleukin-1beta induced p38 [MAPK] activation , COX-2 gene expression , and PGE2 release . Negative_regulation MAPK11 MAP2K6 12738672 1119527 Blocking the *activation* of p44/42 [mitogen activated protein kinase (MAPK)] by the specific mitogen induced extracellular kinase ( ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAPK11 MAP2K6 15284289 1277913 In contrast , a [mitogen activated protein (MAP) kinase/extracellular] signal regulated kinase ( ERK ) kinase ( ) /ERK *inhibitor* , PD98059 , completely abrogated the effect of high glucose . Negative_regulation MAPK11 MAP2K6 19606165 2105686 Overexpression of , a kinase upstream of p38 MAPK , *increased* phosphorylation of p38 [MAPK] and attenuated t-BOOH induced ARPE-19 cell death by 16 % . Negative_regulation MAPK11 MAP2K6 19915797 2197771 We confirmed the interaction between phospho-p38 and MAP4 using immunoprecipitation and found that SB203580 , a [p38/MAPK] *inhibitor* , increases and ( Glu ) overexpression decreases hypoxic cell viability . Negative_regulation MAPK11 MAP2K6 21323644 2447789 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAPK11 MAP2K6 22920673 2710189 We next analysed the effects of inhibiting signalling downstream of Ras , by specific *inhibitors* of [p38MAPK] , PI3-K or , on reoviral killing examined by MTT assay . Negative_regulation MAPK11 MAP2K6 23174698 2735958 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . inhibitor , U0126 completely blocked PKA inhibition *induced* [MAPK] activation and GVBD . Negative_regulation MAPK11 MUC16 22977714 2674034 Rottlerin ( PKCd inhibitor ) inhibited PMA induced expression , and also *inhibited* the phosphorylation of activated p38 [MAPK] by PMA . Negative_regulation MAPK11 PECAM1 19096001 2036133 These findings reveal that [p38MAPK] phosphorylation and platelet activation by LDL are *suppressed* by two mechanisms : ( 1 ) short activation of , and ( 2 ) prolonged activation of SHP-1 and SHP-2 . Negative_regulation MAPK11 PLAU 11606583 888440 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 [MAPK] and *inhibited* cell associated expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation MAPK11 PLAU 23615713 2804732 In addition , avß6 integrin *induced* the phosphorylation of p38 [MAPK] and PI3 K/Akt , contributing to the up-regulation of uPA , as treatment with the specific inhibitor for p38 mitogen activated protein kinases (MAPK) ( SB203580 ) or phosphatidylinositol 3-kinase (PI3 K)/Akt ( LY294002 ) strikingly abrogated expression . Negative_regulation MAPK11 RGS16 11602604 888203 These data suggest that tyrosine phosphorylation regulates RGS16 function and that EGFR may potentially *inhibit* Galpha ( i ) -dependent [MAPK] activation in a feedback loop by enhancing activity through tyrosine phosphorylation . Negative_regulation MAPK11 S100B 19961838 2199382 Albumin activated ERK1/2 , p38 [MAPK] and JNK signaling pathways in astrocytes , and *induced* the production of interleukin (IL)-1beta , inducible nitric oxide (NO) synthase , the NO metabolite nitrite , and the chemokine CX3CL1 while reducing the level of . Negative_regulation MAPK11 SPHK1 22684547 2705920 increased the constitutive expression of extracellular signal regulated kinase1/2 ( ERK1/2 ) but *reduced* the constitutive expression of p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK11 TCN1 23018889 2720294 Furthermore , whereas Compound C ( an AMPK inhibitor ) , AMPK-DN ( AMPK-dominant negative ) mutant , and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA *inhibited* the 8-Cl-cAMP- and AICAR mediated phosphorylation of AMPK and p38 [MAPK] . Negative_regulation MAPK11 TNF 10657669 664217 When KC was instilled as a proinflammatory stimulus , neutrophil accumulation was significantly decreased by p38 [MAPK] *inhibition* independent of or LPS . Negative_regulation MAPK11 TNF 12297293 991243 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Negative_regulation MAPK11 TNF 14729457 1198460 Among other cellular responses , *induces* different forms of cell death and the activation of the p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK11 TNF 15015934 1251072 Stimulation of human skin fibroblasts or articular chondrocytes with IL-1 or in the presence of HC-gp39 *resulted* in a marked reduction of both p38 [mitogen activated protein kinase] and stress activated protein kinase/Jun N-terminal kinase phosphorylation , whereas nuclear translocation of nuclear factor kappaB proceeded unimpeded . Negative_regulation MAPK11 TNF 15519192 1328835 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial TNFalpha mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 [MAPK] activation . Negative_regulation MAPK11 TNF 15763380 1383453 Furthermore , pretreatment with oxymatrine significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet-to-dry weight ratio , decreases in serum level and *inhibition* of phosphorylated p38 [MAPK] . Negative_regulation MAPK11 TNF 15952594 1421641 Pretreatment of EGCG significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet to dry weight ratio , decreased of level in serum and *inhibition* of phosphorylation of p38 [MAPK] . Negative_regulation MAPK11 TNF 17189827 1680105 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Negative_regulation MAPK11 TNF 17214640 1681814 Roxithromycin significantly inhibited induced c-Jun N-terminal kinase activation ( JNP ) and marginally *inhibited* extracellular signal regulated kinase ( ERK ) 1/2 activation , but not p38 [mitogen activated protein kinase] activation . Negative_regulation MAPK11 TNF 17438131 1742710 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Negative_regulation MAPK11 TNF 19086324 2000272 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 [MAPK] and NF-kappaB activities , and then overexpression , thus alleviating the inflammatory reaction . Negative_regulation MAPK11 TNF 19118509 2004841 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and and *inhibited* the phosphorylation of Akt , PKCdelta and p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK11 TNF 19450605 2096916 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 [MAPK] and *inhibited* cardiac expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation MAPK11 TNF 21147093 2378287 LPS induced phosphorylation of I?Ba and p38 [MAPK] was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation MAPK11 TNF 23056531 2685398 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit a ( TNF-a production in cultured macrophages ) and in vitro [MAPK] p38a *inhibition* . Negative_regulation MAPK11 TNF 23066265 2685765 Doxycycline , nonsteroidal anti-inflammatory drugs ( NSAIDs ) , bisphosphonates , nitrous oxide ( NO ) synthase inhibitors , recombinant human interleukin-11 ( rhIL-11 ) , omega-3 fatty acid , mouse anti-human interleukin-6 receptor antibody ( MRA ) , [mitogen activated protein kinase (MAPK)] *inhibitors* , nuclear factor-kappa B (NF-kb) inhibitors , osteoprotegerin , and tumor necrosis factor antagonist ( ) are some of the therapeutic agents that have host modulation properties . Negative_regulation MAPK11 TNF 23518420 2777199 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and protein expression in the kidney , as well as *inhibiting* [p38MAPK] signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation MAPK11 TNF 24152910 2875248 It was found that thrombin down-regulates the HMGB1 mediated induction of both and IL-6 and *inhibits* the activation of both p38 [MAPK] and NF-?B in HUVECs pretreated with PC . Negative_regulation MAPK11 TNF 8665940 368985 Low concentrations ( 2 nM ) of okadaic acid , a serine/threonine phosphatase inhibitor , prevented induced *inhibition* of [MAPK] and restored insulin 's effect on MAPK activity , while orthovanadate ( a tyrosine phosphatase inhibitor ) , inhibitor 2 ( phosphatase-1 inhibitor ) and FK506 ( phosphatase-2B inhibitor ) were ineffective . Negative_regulation MAPK12 ANGPT1 24308939 2877792 The functional roles of DUSPs in *induced* regulation of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Negative_regulation MAPK12 ARSA 18563667 1952779 *inhibited* p38 [MAPK] but not ERK1/2 phosphorylation in washed platelets . Negative_regulation MAPK12 CCND1 19369047 2258045 We propose that breast cancer cell proliferation is inhibited by DHA through proteasome dependent degradation of ERalpha , reduced expression and *inhibition* of [MAPK] signaling . Negative_regulation MAPK12 CCND1 20113529 2213150 In contrast , focal adhesion/actin cytoskeleton , [MAPK] and NF B signaling appeared to characterize the target genes and their interacting proteins in *suppressed* PANC1 cells . Negative_regulation MAPK12 EPHB2 15810889 1392165 Thus , [MAPK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation MAPK12 EPHB2 15910808 1412150 The [MAPK/extracellular] signal regulated protein kinase ( ) kinase *inhibitor* , PD098059 ( 2'-amino-3'-methoxyflavone ) , significantly inhibited basal tone in a dose dependent manner . Negative_regulation MAPK12 EPHB2 16291589 1526008 TCCM treatment activated p38 [mitogen activated protein kinase (MAPK)] and Janus kinase (JNK) but *inhibited* . Negative_regulation MAPK12 EPHB2 16291589 1526036 Thus , our results suggested that tumor induced p38 [MAPK] activation and *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation MAPK12 EPHB2 17615677 1769073 We conclude that activation and p38 [MAPK] *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation MAPK12 EPHB2 18048804 1882900 No significant effects on HO-1 induction were observed with the pretreatment of [mitogen activated protein kinase] pathway *inhibitors* PD98059 ( ) , SB203580 ( p38MAPK ) and JNKi , and conventional and atypical PKC inhibitors . Negative_regulation MAPK12 EPHB2 18567920 1952838 CypA induced nuclear factor kappaB (NF-kappaB) activity for MMP-9 transcription were strongly blocked by extracellular signal regulated kinase ( ) , c-Jun amino terminal kinase (JNK) inhibitors ( U0126 and SP600125 , respectively ) , but not by p38 [mitogen activated protein kinase (MAPK)] *inhibitors* ( SB203580 ) . Negative_regulation MAPK12 EPHB2 19180563 2049266 Activated *suppressed* p38 [MAPK] activation and Fas/FasL protein expression . Negative_regulation MAPK12 EPHB2 19428337 2077013 Histological examination of lung tissues revealed that [MAPK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation MAPK12 EPHB2 20881039 2347117 Extracellular signal regulated receptor kinase ( ) and p38 [mitogen activated protein kinase] *inhibitors* ( U0126 and SB203580 ) were sufficient to block Nup hyperphosphorylation in EMCV infected or L-expressing cells . Negative_regulation MAPK12 EPHB2 21323644 2447791 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) signalling . Negative_regulation MAPK12 EPHB2 21663947 2459765 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation MAPK12 EPHB2 22129743 2515092 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 [mitogen activated protein kinase (MAPK)] and Akt phosphorylation , but in contrast , *inhibited* that of ( 1/2 ) . Negative_regulation MAPK12 EPHB2 22521802 2630855 Overexpression of the signaling protein Smad3 *enhanced* TGF-ß induced activation of ERK [MAPK] , whereas inhibition of Smad3 with a siRNA blocked MAPK phosphorylation in response to TGF-ß . Negative_regulation MAPK12 FAS 15669079 1382144 Concurrently , blockade drastically *activated* [MAPK] and promoted further a prominent accumulation of HIF-1alpha in Her-2/neu overexpressors . Negative_regulation MAPK12 FHL1 23456229 2781800 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Negative_regulation MAPK12 FUT4 20506505 2307910 Results show that overexpression of *increases* the phosphorylation of ERK1/2 , p38 [MAPK] , and PI3K/Akt . Negative_regulation MAPK12 HBEGF 19048624 2023702 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked [MAPK] signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 MAPK , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Negative_regulation MAPK12 HBEGF 19919524 2166801 Western blot analysis showed *prevents* ethanol from altering [MAPK] phosphorylation . Negative_regulation MAPK12 IL1B 12388337 1031323 CO treatment inhibited induced ERK1/2 activation but did not *inhibit* JNK and p38 [MAPK] . Negative_regulation MAPK12 IL1B 16718462 1584871 A synthetic peptide , C3d , reported to bind NCAM , did not activate [MAPK] or Akt as reported in neurons but *inhibited* induced MAPK activity , thereby mimicking the effect of SU5402 . Negative_regulation MAPK12 IL1B 18669445 1973094 DPML significantly inhibited tumor necrosis factor alpha , , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 [mitogen activated protein kinase] activation in the lung . Negative_regulation MAPK12 IL1B 19214751 2071808 triggered the activation of p38 and ERK1/2 ( p44/42) MAP kinase (MAPK) signaling pathways , but WIN55,212-2 mainly *inhibited* p38 [MAPK] phosphorylation . Negative_regulation MAPK12 LBP 19010986 2029059 and sCD14 *inhibited* the nontypeable Haemophilus influenzae ( NTHi ) -dependent secretion of IL-8 and the activation of NF-kappaB and p38 [mitogen activated protein kinase] signalling pathways but they increased the internalisation of NTHi by airway epithelial cells . Negative_regulation MAPK12 MAP2K6 11237743 790217 The [MAPK] kinase ( ) *inhibitor* , PD98059 , blocked GSA stimulated MAPK activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Negative_regulation MAPK12 MAP2K6 11258898 795498 T ( 4 ) -induced nuclear complexing of p53 and MAPK was inhibited by PD 98059 ( PD ) and U0126 , two [MAPK] kinase ( ) *inhibitors* , and was absent in cells treated with MEK antisense oligonucleotide and in dominant negative Ras cells . Negative_regulation MAPK12 MAP2K6 11304531 826791 The activation of p38 [MAPK] by Galpha ( q ) and Gbetagamma was *blocked* by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Negative_regulation MAPK12 MAP2K6 11399487 824141 The role of MAPK activation on GPalpha , FSHbeta and LHbeta gene expression was determined by administration of [MAPK-kinase] ( ) *inhibitor* ( PD98059 ; Negative_regulation MAPK12 MAP2K6 11744690 915753 Furthermore , the activation of p38 [MAPK] caused by overexpressing active RasVHa could not be inhibited using dominant negative mutants of MyD88 , IRAK , or IRAK-2 , or TRAF6 , but could be *inhibited* by dominant negative MKK3 or . Negative_regulation MAPK12 MAP2K6 11787422 891839 Indeed the [MAPK] kinase ( = ) *inhibitor* PD98059 inhibits the activation of parasite MAPK , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Negative_regulation MAPK12 MAP2K6 12649265 1080038 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant or p38beta2 MAPK *inhibited* interleukin-1beta induced p38 [MAPK] activation , COX-2 gene expression , and PGE2 release . Negative_regulation MAPK12 MAP2K6 12738672 1119534 Blocking the *activation* of p44/42 [mitogen activated protein kinase (MAPK)] by the specific mitogen induced extracellular kinase ( ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAPK12 MAP2K6 15284289 1277920 In contrast , a [mitogen activated protein (MAP) kinase/extracellular] signal regulated kinase ( ERK ) kinase ( ) /ERK *inhibitor* , PD98059 , completely abrogated the effect of high glucose . Negative_regulation MAPK12 MAP2K6 19606165 2105687 Overexpression of , a kinase upstream of p38 MAPK , *increased* phosphorylation of p38 [MAPK] and attenuated t-BOOH induced ARPE-19 cell death by 16 % . Negative_regulation MAPK12 MAP2K6 19915797 2197772 We confirmed the interaction between phospho-p38 and MAP4 using immunoprecipitation and found that SB203580 , a [p38/MAPK] *inhibitor* , increases and ( Glu ) overexpression decreases hypoxic cell viability . Negative_regulation MAPK12 MAP2K6 21323644 2447797 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAPK12 MAP2K6 22920673 2710198 We next analysed the effects of inhibiting signalling downstream of Ras , by specific *inhibitors* of [p38MAPK] , PI3-K or , on reoviral killing examined by MTT assay . Negative_regulation MAPK12 MAP2K6 23174698 2735965 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . inhibitor , U0126 completely blocked PKA inhibition *induced* [MAPK] activation and GVBD . Negative_regulation MAPK12 MUC16 22977714 2674035 Rottlerin ( PKCd inhibitor ) inhibited PMA induced expression , and also *inhibited* the phosphorylation of activated p38 [MAPK] by PMA . Negative_regulation MAPK12 PECAM1 19096001 2036139 These findings reveal that [p38MAPK] phosphorylation and platelet activation by LDL are *suppressed* by two mechanisms : ( 1 ) short activation of , and ( 2 ) prolonged activation of SHP-1 and SHP-2 . Negative_regulation MAPK12 PLAU 11606583 888441 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 [MAPK] and *inhibited* cell associated expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation MAPK12 PLAU 23615713 2804733 In addition , avß6 integrin *induced* the phosphorylation of p38 [MAPK] and PI3 K/Akt , contributing to the up-regulation of uPA , as treatment with the specific inhibitor for p38 mitogen activated protein kinases (MAPK) ( SB203580 ) or phosphatidylinositol 3-kinase (PI3 K)/Akt ( LY294002 ) strikingly abrogated expression . Negative_regulation MAPK12 RGS16 11602604 888205 These data suggest that tyrosine phosphorylation regulates function and that EGFR may potentially *inhibit* Galpha ( i ) -dependent [MAPK] activation in a feedback loop by enhancing RGS16 activity through tyrosine phosphorylation . Negative_regulation MAPK12 S100B 19961838 2199383 Albumin activated ERK1/2 , p38 [MAPK] and JNK signaling pathways in astrocytes , and *induced* the production of interleukin (IL)-1beta , inducible nitric oxide (NO) synthase , the NO metabolite nitrite , and the chemokine CX3CL1 while reducing the level of . Negative_regulation MAPK12 SPHK1 22684547 2705921 increased the constitutive expression of extracellular signal regulated kinase1/2 ( ERK1/2 ) but *reduced* the constitutive expression of p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK12 TCN1 23018889 2720302 Furthermore , whereas Compound C ( an AMPK inhibitor ) , AMPK-DN ( AMPK-dominant negative ) mutant , and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA *inhibited* the 8-Cl-cAMP- and AICAR mediated phosphorylation of AMPK and p38 [MAPK] . Negative_regulation MAPK12 TNF 10657669 664219 When KC was instilled as a proinflammatory stimulus , neutrophil accumulation was significantly decreased by p38 [MAPK] *inhibition* independent of or LPS . Negative_regulation MAPK12 TNF 12297293 991244 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Negative_regulation MAPK12 TNF 14729457 1198461 Among other cellular responses , *induces* different forms of cell death and the activation of the p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK12 TNF 15015934 1251074 Stimulation of human skin fibroblasts or articular chondrocytes with IL-1 or in the presence of HC-gp39 *resulted* in a marked reduction of both p38 [mitogen activated protein kinase] and stress activated protein kinase/Jun N-terminal kinase phosphorylation , whereas nuclear translocation of nuclear factor kappaB proceeded unimpeded . Negative_regulation MAPK12 TNF 15519192 1328836 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as TNFalpha production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 [MAPK] activation . Negative_regulation MAPK12 TNF 15763380 1383454 Furthermore , pretreatment with oxymatrine significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet-to-dry weight ratio , decreases in serum level and *inhibition* of phosphorylated p38 [MAPK] . Negative_regulation MAPK12 TNF 15952594 1421642 Pretreatment of EGCG significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet to dry weight ratio , decreased of level in serum and *inhibition* of phosphorylation of p38 [MAPK] . Negative_regulation MAPK12 TNF 17189827 1680107 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Negative_regulation MAPK12 TNF 17214640 1681816 Roxithromycin significantly inhibited induced c-Jun N-terminal kinase activation ( JNP ) and marginally *inhibited* extracellular signal regulated kinase ( ERK ) 1/2 activation , but not p38 [mitogen activated protein kinase] activation . Negative_regulation MAPK12 TNF 17438131 1742711 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Negative_regulation MAPK12 TNF 19086324 2000273 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 [MAPK] and NF-kappaB activities , and then overexpression , thus alleviating the inflammatory reaction . Negative_regulation MAPK12 TNF 19118509 2004844 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and and *inhibited* the phosphorylation of Akt , PKCdelta and p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK12 TNF 19450605 2096917 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 [MAPK] and *inhibited* cardiac expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation MAPK12 TNF 21147093 2378290 LPS induced phosphorylation of I?Ba and p38 [MAPK] was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation MAPK12 TNF 23056531 2685400 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit a ( TNF-a production in cultured macrophages ) and in vitro [MAPK] p38a *inhibition* . Negative_regulation MAPK12 TNF 23066265 2685766 Doxycycline , nonsteroidal anti-inflammatory drugs ( NSAIDs ) , bisphosphonates , nitrous oxide ( NO ) synthase inhibitors , recombinant human interleukin-11 ( rhIL-11 ) , omega-3 fatty acid , mouse anti-human interleukin-6 receptor antibody ( MRA ) , [mitogen activated protein kinase (MAPK)] *inhibitors* , nuclear factor-kappa B (NF-kb) inhibitors , osteoprotegerin , and tumor necrosis factor antagonist ( ) are some of the therapeutic agents that have host modulation properties . Negative_regulation MAPK12 TNF 23518420 2777200 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and protein expression in the kidney , as well as *inhibiting* [p38MAPK] signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation MAPK12 TNF 24152910 2875251 It was found that thrombin down-regulates the HMGB1 mediated induction of both and IL-6 and *inhibits* the activation of both p38 [MAPK] and NF-?B in HUVECs pretreated with PC . Negative_regulation MAPK12 TNF 8665940 368986 Low concentrations ( 2 nM ) of okadaic acid , a serine/threonine phosphatase inhibitor , prevented *induced* inhibition of [MAPK] and restored insulin 's effect on MAPK activity , while orthovanadate ( a tyrosine phosphatase inhibitor ) , inhibitor 2 ( phosphatase-1 inhibitor ) and FK506 ( phosphatase-2B inhibitor ) were ineffective . Negative_regulation MAPK13 ANGPT1 24308939 2877793 The functional roles of DUSPs in *induced* regulation of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Negative_regulation MAPK13 ARSA 18563667 1952780 *inhibited* p38 [MAPK] but not ERK1/2 phosphorylation in washed platelets . Negative_regulation MAPK13 CCND1 19369047 2258046 We propose that breast cancer cell proliferation is inhibited by DHA through proteasome dependent degradation of ERalpha , reduced expression and *inhibition* of [MAPK] signaling . Negative_regulation MAPK13 CCND1 20113529 2213151 In contrast , focal adhesion/actin cytoskeleton , [MAPK] and NF B signaling appeared to characterize the target genes and their interacting proteins in *suppressed* PANC1 cells . Negative_regulation MAPK13 EPHB2 15810889 1392166 Thus , [MAPK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation MAPK13 EPHB2 15910808 1412151 The [MAPK/extracellular] signal regulated protein kinase ( ) kinase *inhibitor* , PD098059 ( 2'-amino-3'-methoxyflavone ) , significantly inhibited basal tone in a dose dependent manner . Negative_regulation MAPK13 EPHB2 16291589 1526009 TCCM treatment activated p38 [mitogen activated protein kinase (MAPK)] and Janus kinase (JNK) but *inhibited* . Negative_regulation MAPK13 EPHB2 16291589 1526037 Thus , our results suggested that tumor induced p38 [MAPK] activation and *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation MAPK13 EPHB2 17615677 1769075 We conclude that activation and p38 [MAPK] *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation MAPK13 EPHB2 18048804 1882901 No significant effects on HO-1 induction were observed with the pretreatment of [mitogen activated protein kinase] pathway *inhibitors* PD98059 ( ) , SB203580 ( p38MAPK ) and JNKi , and conventional and atypical PKC inhibitors . Negative_regulation MAPK13 EPHB2 18567920 1952839 CypA induced nuclear factor kappaB (NF-kappaB) activity for MMP-9 transcription were strongly blocked by extracellular signal regulated kinase ( ) , c-Jun amino terminal kinase (JNK) inhibitors ( U0126 and SP600125 , respectively ) , but not by p38 [mitogen activated protein kinase (MAPK)] *inhibitors* ( SB203580 ) . Negative_regulation MAPK13 EPHB2 19180563 2049267 Activated *suppressed* p38 [MAPK] activation and Fas/FasL protein expression . Negative_regulation MAPK13 EPHB2 19428337 2077014 Histological examination of lung tissues revealed that [MAPK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation MAPK13 EPHB2 20881039 2347118 Extracellular signal regulated receptor kinase ( ) and p38 [mitogen activated protein kinase] *inhibitors* ( U0126 and SB203580 ) were sufficient to block Nup hyperphosphorylation in EMCV infected or L-expressing cells . Negative_regulation MAPK13 EPHB2 21323644 2447799 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) signalling . Negative_regulation MAPK13 EPHB2 21663947 2459768 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation MAPK13 EPHB2 22129743 2515093 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 [mitogen activated protein kinase (MAPK)] and Akt phosphorylation , but in contrast , *inhibited* that of ( 1/2 ) . Negative_regulation MAPK13 EPHB2 22521802 2630857 Overexpression of the signaling protein Smad3 *enhanced* TGF-ß induced activation of ERK [MAPK] , whereas inhibition of Smad3 with a siRNA blocked MAPK phosphorylation in response to TGF-ß . Negative_regulation MAPK13 FAS 15669079 1382145 Concurrently , blockade drastically *activated* [MAPK] and promoted further a prominent accumulation of HIF-1alpha in Her-2/neu overexpressors . Negative_regulation MAPK13 FHL1 23456229 2781801 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Negative_regulation MAPK13 FUT4 20506505 2307911 Results show that overexpression of *increases* the phosphorylation of ERK1/2 , p38 [MAPK] , and PI3K/Akt . Negative_regulation MAPK13 HBEGF 19048624 2023703 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked MAPK signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 [MAPK] , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Negative_regulation MAPK13 HBEGF 19919524 2166802 Western blot analysis showed *prevents* ethanol from altering [MAPK] phosphorylation . Negative_regulation MAPK13 IL1B 12388337 1031325 CO treatment inhibited induced ERK1/2 activation but did not *inhibit* JNK and p38 [MAPK] . Negative_regulation MAPK13 IL1B 16718462 1584875 A synthetic peptide , C3d , reported to bind NCAM , did not activate [MAPK] or Akt as reported in neurons but *inhibited* induced MAPK activity , thereby mimicking the effect of SU5402 . Negative_regulation MAPK13 IL1B 18669445 1973096 DPML significantly inhibited tumor necrosis factor alpha , , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 [mitogen activated protein kinase] activation in the lung . Negative_regulation MAPK13 IL1B 19214751 2071811 triggered the activation of p38 and ERK1/2 ( p44/42) MAP kinase (MAPK) signaling pathways , but WIN55,212-2 mainly *inhibited* p38 [MAPK] phosphorylation . Negative_regulation MAPK13 LBP 19010986 2029060 and sCD14 *inhibited* the nontypeable Haemophilus influenzae ( NTHi ) -dependent secretion of IL-8 and the activation of NF-kappaB and p38 [mitogen activated protein kinase] signalling pathways but they increased the internalisation of NTHi by airway epithelial cells . Negative_regulation MAPK13 MAP2K6 11237743 790224 The [MAPK] kinase ( ) *inhibitor* , PD98059 , blocked GSA stimulated MAPK activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Negative_regulation MAPK13 MAP2K6 11258898 795505 T ( 4 ) -induced nuclear complexing of p53 and MAPK was inhibited by PD 98059 ( PD ) and U0126 , two [MAPK] kinase ( ) *inhibitors* , and was absent in cells treated with MEK antisense oligonucleotide and in dominant negative Ras cells . Negative_regulation MAPK13 MAP2K6 11304531 826794 The activation of p38 [MAPK] by Galpha ( q ) and Gbetagamma was *blocked* by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Negative_regulation MAPK13 MAP2K6 11399487 824148 The role of MAPK activation on GPalpha , FSHbeta and LHbeta gene expression was determined by administration of [MAPK-kinase] ( ) *inhibitor* ( PD98059 ; Negative_regulation MAPK13 MAP2K6 11744690 915755 Furthermore , the activation of p38 [MAPK] caused by overexpressing active RasVHa could not be inhibited using dominant negative mutants of MyD88 , IRAK , or IRAK-2 , or TRAF6 , but could be *inhibited* by dominant negative MKK3 or . Negative_regulation MAPK13 MAP2K6 11787422 891846 Indeed the [MAPK] kinase ( = ) *inhibitor* PD98059 inhibits the activation of parasite MAPK , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Negative_regulation MAPK13 MAP2K6 12649265 1080039 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant or p38beta2 MAPK *inhibited* interleukin-1beta induced p38 [MAPK] activation , COX-2 gene expression , and PGE2 release . Negative_regulation MAPK13 MAP2K6 12738672 1119541 Blocking the *activation* of p44/42 [mitogen activated protein kinase (MAPK)] by the specific mitogen induced extracellular kinase ( ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAPK13 MAP2K6 15284289 1277927 In contrast , a [mitogen activated protein (MAP) kinase/extracellular] signal regulated kinase ( ERK ) kinase ( ) /ERK *inhibitor* , PD98059 , completely abrogated the effect of high glucose . Negative_regulation MAPK13 MAP2K6 19606165 2105688 Overexpression of , a kinase upstream of p38 MAPK , *increased* phosphorylation of p38 [MAPK] and attenuated t-BOOH induced ARPE-19 cell death by 16 % . Negative_regulation MAPK13 MAP2K6 19915797 2197773 We confirmed the interaction between phospho-p38 and MAP4 using immunoprecipitation and found that SB203580 , a [p38/MAPK] *inhibitor* , increases and ( Glu ) overexpression decreases hypoxic cell viability . Negative_regulation MAPK13 MAP2K6 21323644 2447805 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAPK13 MAP2K6 22920673 2710207 We next analysed the effects of inhibiting signalling downstream of Ras , by specific *inhibitors* of [p38MAPK] , PI3-K or , on reoviral killing examined by MTT assay . Negative_regulation MAPK13 MAP2K6 23174698 2735972 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . inhibitor , U0126 completely blocked PKA inhibition *induced* [MAPK] activation and GVBD . Negative_regulation MAPK13 MUC16 22977714 2674036 Rottlerin ( PKCd inhibitor ) inhibited PMA induced expression , and also *inhibited* the phosphorylation of activated p38 [MAPK] by PMA . Negative_regulation MAPK13 PECAM1 19096001 2036145 These findings reveal that [p38MAPK] phosphorylation and platelet activation by LDL are *suppressed* by two mechanisms : ( 1 ) short activation of , and ( 2 ) prolonged activation of SHP-1 and SHP-2 . Negative_regulation MAPK13 PLAU 11606583 888442 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 [MAPK] and *inhibited* cell associated expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation MAPK13 PLAU 23615713 2804734 In addition , avß6 integrin *induced* the phosphorylation of p38 [MAPK] and PI3 K/Akt , contributing to the up-regulation of uPA , as treatment with the specific inhibitor for p38 mitogen activated protein kinases (MAPK) ( SB203580 ) or phosphatidylinositol 3-kinase (PI3 K)/Akt ( LY294002 ) strikingly abrogated expression . Negative_regulation MAPK13 RGS16 11602604 888207 These data suggest that tyrosine phosphorylation regulates RGS16 function and that EGFR may potentially *inhibit* Galpha ( i ) -dependent [MAPK] activation in a feedback loop by enhancing activity through tyrosine phosphorylation . Negative_regulation MAPK13 S100B 19961838 2199384 Albumin activated ERK1/2 , p38 [MAPK] and JNK signaling pathways in astrocytes , and *induced* the production of interleukin (IL)-1beta , inducible nitric oxide (NO) synthase , the NO metabolite nitrite , and the chemokine CX3CL1 while reducing the level of . Negative_regulation MAPK13 SPHK1 22684547 2705922 increased the constitutive expression of extracellular signal regulated kinase1/2 ( ERK1/2 ) but *reduced* the constitutive expression of p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK13 TCN1 23018889 2720310 Furthermore , whereas Compound C ( an AMPK inhibitor ) , AMPK-DN ( AMPK-dominant negative ) mutant , and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA *inhibited* the 8-Cl-cAMP- and AICAR mediated phosphorylation of AMPK and p38 [MAPK] . Negative_regulation MAPK13 TNF 10657669 664221 When KC was instilled as a proinflammatory stimulus , neutrophil accumulation was significantly decreased by p38 [MAPK] *inhibition* independent of or LPS . Negative_regulation MAPK13 TNF 12297293 991245 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Negative_regulation MAPK13 TNF 14729457 1198462 Among other cellular responses , *induces* different forms of cell death and the activation of the p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK13 TNF 15015934 1251076 Stimulation of human skin fibroblasts or articular chondrocytes with IL-1 or in the presence of HC-gp39 *resulted* in a marked reduction of both p38 [mitogen activated protein kinase] and stress activated protein kinase/Jun N-terminal kinase phosphorylation , whereas nuclear translocation of nuclear factor kappaB proceeded unimpeded . Negative_regulation MAPK13 TNF 15519192 1328837 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial TNFalpha mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 [MAPK] activation . Negative_regulation MAPK13 TNF 15763380 1383455 Furthermore , pretreatment with oxymatrine significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet-to-dry weight ratio , decreases in serum level and *inhibition* of phosphorylated p38 [MAPK] . Negative_regulation MAPK13 TNF 15952594 1421643 Pretreatment of EGCG significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet to dry weight ratio , decreased of level in serum and *inhibition* of phosphorylation of p38 [MAPK] . Negative_regulation MAPK13 TNF 17189827 1680109 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Negative_regulation MAPK13 TNF 17214640 1681818 Roxithromycin significantly inhibited induced c-Jun N-terminal kinase activation ( JNP ) and marginally *inhibited* extracellular signal regulated kinase ( ERK ) 1/2 activation , but not p38 [mitogen activated protein kinase] activation . Negative_regulation MAPK13 TNF 17438131 1742712 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Negative_regulation MAPK13 TNF 19086324 2000274 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 [MAPK] and NF-kappaB activities , and then overexpression , thus alleviating the inflammatory reaction . Negative_regulation MAPK13 TNF 19118509 2004847 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and and *inhibited* the phosphorylation of Akt , PKCdelta and p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK13 TNF 19450605 2096918 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 [MAPK] and *inhibited* cardiac expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation MAPK13 TNF 21147093 2378293 LPS induced phosphorylation of I?Ba and p38 [MAPK] was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation MAPK13 TNF 23056531 2685402 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit a ( TNF-a production in cultured macrophages ) and in vitro [MAPK] p38a *inhibition* . Negative_regulation MAPK13 TNF 23066265 2685767 Doxycycline , nonsteroidal anti-inflammatory drugs ( NSAIDs ) , bisphosphonates , nitrous oxide ( NO ) synthase inhibitors , recombinant human interleukin-11 ( rhIL-11 ) , omega-3 fatty acid , mouse anti-human interleukin-6 receptor antibody ( MRA ) , [mitogen activated protein kinase (MAPK)] *inhibitors* , nuclear factor-kappa B (NF-kb) inhibitors , osteoprotegerin , and tumor necrosis factor antagonist ( ) are some of the therapeutic agents that have host modulation properties . Negative_regulation MAPK13 TNF 23518420 2777201 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and protein expression in the kidney , as well as *inhibiting* [p38MAPK] signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation MAPK13 TNF 24152910 2875254 It was found that thrombin down-regulates the HMGB1 mediated induction of both and IL-6 and *inhibits* the activation of both p38 [MAPK] and NF-?B in HUVECs pretreated with PC . Negative_regulation MAPK13 TNF 8665940 368987 Low concentrations ( 2 nM ) of okadaic acid , a serine/threonine phosphatase inhibitor , prevented induced *inhibition* of [MAPK] and restored insulin 's effect on MAPK activity , while orthovanadate ( a tyrosine phosphatase inhibitor ) , inhibitor 2 ( phosphatase-1 inhibitor ) and FK506 ( phosphatase-2B inhibitor ) were ineffective . Negative_regulation MAPK14 ANGPT1 24308939 2877794 The functional roles of DUSPs in *induced* regulation of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Negative_regulation MAPK14 ARSA 18563667 1952781 *inhibited* p38 [MAPK] but not ERK1/2 phosphorylation in washed platelets . Negative_regulation MAPK14 CCND1 19369047 2258047 We propose that breast cancer cell proliferation is inhibited by DHA through proteasome dependent degradation of ERalpha , reduced expression and *inhibition* of [MAPK] signaling . Negative_regulation MAPK14 CCND1 20113529 2213152 In contrast , focal adhesion/actin cytoskeleton , [MAPK] and NF B signaling appeared to characterize the target genes and their interacting proteins in *suppressed* PANC1 cells . Negative_regulation MAPK14 EPHB2 15810889 1392167 Thus , [MAPK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation MAPK14 EPHB2 15910808 1412152 The [MAPK/extracellular] signal regulated protein kinase ( ) kinase *inhibitor* , PD098059 ( 2'-amino-3'-methoxyflavone ) , significantly inhibited basal tone in a dose dependent manner . Negative_regulation MAPK14 EPHB2 16291589 1526010 TCCM treatment activated p38 [mitogen activated protein kinase (MAPK)] and Janus kinase (JNK) but *inhibited* . Negative_regulation MAPK14 EPHB2 16291589 1526038 Thus , our results suggested that tumor induced p38 [MAPK] activation and *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation MAPK14 EPHB2 17615677 1769077 We conclude that activation and p38 [MAPK] *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation MAPK14 EPHB2 18048804 1882902 No significant effects on HO-1 induction were observed with the pretreatment of [mitogen activated protein kinase] pathway *inhibitors* PD98059 ( ) , SB203580 ( p38MAPK ) and JNKi , and conventional and atypical PKC inhibitors . Negative_regulation MAPK14 EPHB2 18567920 1952840 CypA induced nuclear factor kappaB (NF-kappaB) activity for MMP-9 transcription were strongly blocked by extracellular signal regulated kinase ( ) , c-Jun amino terminal kinase (JNK) inhibitors ( U0126 and SP600125 , respectively ) , but not by p38 [mitogen activated protein kinase (MAPK)] *inhibitors* ( SB203580 ) . Negative_regulation MAPK14 EPHB2 19180563 2049268 Activated *suppressed* p38 [MAPK] activation and Fas/FasL protein expression . Negative_regulation MAPK14 EPHB2 19428337 2077015 Histological examination of lung tissues revealed that [MAPK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation MAPK14 EPHB2 20881039 2347119 Extracellular signal regulated receptor kinase ( ) and p38 [mitogen activated protein kinase] *inhibitors* ( U0126 and SB203580 ) were sufficient to block Nup hyperphosphorylation in EMCV infected or L-expressing cells . Negative_regulation MAPK14 EPHB2 21323644 2447807 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) signalling . Negative_regulation MAPK14 EPHB2 21663947 2459771 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation MAPK14 EPHB2 22129743 2515094 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 [mitogen activated protein kinase (MAPK)] and Akt phosphorylation , but in contrast , *inhibited* that of ( 1/2 ) . Negative_regulation MAPK14 EPHB2 22521802 2630859 Overexpression of the signaling protein Smad3 *enhanced* TGF-ß induced activation of ERK [MAPK] , whereas inhibition of Smad3 with a siRNA blocked MAPK phosphorylation in response to TGF-ß . Negative_regulation MAPK14 FAS 15669079 1382146 Concurrently , blockade drastically *activated* [MAPK] and promoted further a prominent accumulation of HIF-1alpha in Her-2/neu overexpressors . Negative_regulation MAPK14 FHL1 23456229 2781802 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Negative_regulation MAPK14 FUT4 20506505 2307912 Results show that overexpression of *increases* the phosphorylation of ERK1/2 , p38 [MAPK] , and PI3K/Akt . Negative_regulation MAPK14 HBEGF 19048624 2023704 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked [MAPK] signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 MAPK , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Negative_regulation MAPK14 HBEGF 19919524 2166803 Western blot analysis showed *prevents* ethanol from altering [MAPK] phosphorylation . Negative_regulation MAPK14 IL1B 12388337 1031327 CO treatment inhibited induced ERK1/2 activation but did not *inhibit* JNK and p38 [MAPK] . Negative_regulation MAPK14 IL1B 16718462 1584879 A synthetic peptide , C3d , reported to bind NCAM , did not activate [MAPK] or Akt as reported in neurons but *inhibited* induced MAPK activity , thereby mimicking the effect of SU5402 . Negative_regulation MAPK14 IL1B 18669445 1973098 DPML significantly inhibited tumor necrosis factor alpha , , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 [mitogen activated protein kinase] activation in the lung . Negative_regulation MAPK14 IL1B 19214751 2071814 triggered the activation of p38 and ERK1/2 ( p44/42) MAP kinase (MAPK) signaling pathways , but WIN55,212-2 mainly *inhibited* p38 [MAPK] phosphorylation . Negative_regulation MAPK14 LBP 19010986 2029061 and sCD14 *inhibited* the nontypeable Haemophilus influenzae ( NTHi ) -dependent secretion of IL-8 and the activation of NF-kappaB and p38 [mitogen activated protein kinase] signalling pathways but they increased the internalisation of NTHi by airway epithelial cells . Negative_regulation MAPK14 MAP2K6 11237743 790231 The [MAPK] kinase ( ) *inhibitor* , PD98059 , blocked GSA stimulated MAPK activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Negative_regulation MAPK14 MAP2K6 11258898 795512 T ( 4 ) -induced nuclear complexing of p53 and MAPK was inhibited by PD 98059 ( PD ) and U0126 , two [MAPK] kinase ( ) *inhibitors* , and was absent in cells treated with MEK antisense oligonucleotide and in dominant negative Ras cells . Negative_regulation MAPK14 MAP2K6 11304531 826797 The activation of p38 [MAPK] by Galpha ( q ) and Gbetagamma was *blocked* by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Negative_regulation MAPK14 MAP2K6 11399487 824155 The role of MAPK activation on GPalpha , FSHbeta and LHbeta gene expression was determined by administration of [MAPK-kinase] ( ) *inhibitor* ( PD98059 ; Negative_regulation MAPK14 MAP2K6 11744690 915757 Furthermore , the activation of p38 [MAPK] caused by overexpressing active RasVHa could not be inhibited using dominant negative mutants of MyD88 , IRAK , or IRAK-2 , or TRAF6 , but could be *inhibited* by dominant negative MKK3 or . Negative_regulation MAPK14 MAP2K6 11787422 891853 Indeed the [MAPK] kinase ( = ) *inhibitor* PD98059 inhibits the activation of parasite MAPK , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Negative_regulation MAPK14 MAP2K6 12649265 1080040 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant or p38beta2 MAPK *inhibited* interleukin-1beta induced p38 [MAPK] activation , COX-2 gene expression , and PGE2 release . Negative_regulation MAPK14 MAP2K6 12738672 1119548 Blocking the *activation* of p44/42 [mitogen activated protein kinase (MAPK)] by the specific mitogen induced extracellular kinase ( ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAPK14 MAP2K6 15284289 1277934 In contrast , a [mitogen activated protein (MAP) kinase/extracellular] signal regulated kinase ( ERK ) kinase ( ) /ERK *inhibitor* , PD98059 , completely abrogated the effect of high glucose . Negative_regulation MAPK14 MAP2K6 19606165 2105689 Overexpression of , a kinase upstream of p38 MAPK , *increased* phosphorylation of p38 [MAPK] and attenuated t-BOOH induced ARPE-19 cell death by 16 % . Negative_regulation MAPK14 MAP2K6 19915797 2197774 We confirmed the interaction between phospho-p38 and MAP4 using immunoprecipitation and found that SB203580 , a [p38/MAPK] *inhibitor* , increases and ( Glu ) overexpression decreases hypoxic cell viability . Negative_regulation MAPK14 MAP2K6 21323644 2447813 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAPK14 MAP2K6 22920673 2710216 We next analysed the effects of inhibiting signalling downstream of Ras , by specific *inhibitors* of [p38MAPK] , PI3-K or , on reoviral killing examined by MTT assay . Negative_regulation MAPK14 MAP2K6 23174698 2735979 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . inhibitor , U0126 completely blocked PKA inhibition *induced* [MAPK] activation and GVBD . Negative_regulation MAPK14 MUC16 22977714 2674037 Rottlerin ( PKCd inhibitor ) inhibited PMA induced expression , and also *inhibited* the phosphorylation of activated p38 [MAPK] by PMA . Negative_regulation MAPK14 PECAM1 19096001 2036151 These findings reveal that [p38MAPK] phosphorylation and platelet activation by LDL are *suppressed* by two mechanisms : ( 1 ) short activation of , and ( 2 ) prolonged activation of SHP-1 and SHP-2 . Negative_regulation MAPK14 PLAU 11606583 888443 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 [MAPK] and *inhibited* cell associated expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation MAPK14 PLAU 23615713 2804735 In addition , avß6 integrin *induced* the phosphorylation of p38 [MAPK] and PI3 K/Akt , contributing to the up-regulation of uPA , as treatment with the specific inhibitor for p38 mitogen activated protein kinases (MAPK) ( SB203580 ) or phosphatidylinositol 3-kinase (PI3 K)/Akt ( LY294002 ) strikingly abrogated expression . Negative_regulation MAPK14 RGS16 11602604 888209 These data suggest that tyrosine phosphorylation regulates function and that EGFR may potentially *inhibit* Galpha ( i ) -dependent [MAPK] activation in a feedback loop by enhancing RGS16 activity through tyrosine phosphorylation . Negative_regulation MAPK14 S100B 19961838 2199385 Albumin activated ERK1/2 , p38 [MAPK] and JNK signaling pathways in astrocytes , and *induced* the production of interleukin (IL)-1beta , inducible nitric oxide (NO) synthase , the NO metabolite nitrite , and the chemokine CX3CL1 while reducing the level of . Negative_regulation MAPK14 SPHK1 22684547 2705923 increased the constitutive expression of extracellular signal regulated kinase1/2 ( ERK1/2 ) but *reduced* the constitutive expression of p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK14 TCN1 23018889 2720318 Furthermore , whereas Compound C ( an AMPK inhibitor ) , AMPK-DN ( AMPK-dominant negative ) mutant , and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA *inhibited* the 8-Cl-cAMP- and AICAR mediated phosphorylation of AMPK and p38 [MAPK] . Negative_regulation MAPK14 TNF 10657669 664223 When KC was instilled as a proinflammatory stimulus , neutrophil accumulation was significantly decreased by p38 [MAPK] *inhibition* independent of or LPS . Negative_regulation MAPK14 TNF 12297293 991246 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Negative_regulation MAPK14 TNF 14729457 1198463 Among other cellular responses , *induces* different forms of cell death and the activation of the p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK14 TNF 15015934 1251078 Stimulation of human skin fibroblasts or articular chondrocytes with IL-1 or in the presence of HC-gp39 *resulted* in a marked reduction of both p38 [mitogen activated protein kinase] and stress activated protein kinase/Jun N-terminal kinase phosphorylation , whereas nuclear translocation of nuclear factor kappaB proceeded unimpeded . Negative_regulation MAPK14 TNF 15519192 1328838 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as TNFalpha production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 [MAPK] activation . Negative_regulation MAPK14 TNF 15763380 1383456 Furthermore , pretreatment with oxymatrine significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet-to-dry weight ratio , decreases in serum level and *inhibition* of phosphorylated p38 [MAPK] . Negative_regulation MAPK14 TNF 15952594 1421644 Pretreatment of EGCG significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet to dry weight ratio , decreased of level in serum and *inhibition* of phosphorylation of p38 [MAPK] . Negative_regulation MAPK14 TNF 17189827 1680111 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Negative_regulation MAPK14 TNF 17214640 1681820 Roxithromycin significantly inhibited induced c-Jun N-terminal kinase activation ( JNP ) and marginally *inhibited* extracellular signal regulated kinase ( ERK ) 1/2 activation , but not p38 [mitogen activated protein kinase] activation . Negative_regulation MAPK14 TNF 17438131 1742713 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Negative_regulation MAPK14 TNF 19086324 2000275 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 [MAPK] and NF-kappaB activities , and then overexpression , thus alleviating the inflammatory reaction . Negative_regulation MAPK14 TNF 19118509 2004850 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and and *inhibited* the phosphorylation of Akt , PKCdelta and p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK14 TNF 19450605 2096919 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 [MAPK] and *inhibited* cardiac expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation MAPK14 TNF 21147093 2378296 LPS induced phosphorylation of I?Ba and p38 [MAPK] was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation MAPK14 TNF 23056531 2685404 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit a ( TNF-a production in cultured macrophages ) and in vitro [MAPK] p38a *inhibition* . Negative_regulation MAPK14 TNF 23066265 2685768 Doxycycline , nonsteroidal anti-inflammatory drugs ( NSAIDs ) , bisphosphonates , nitrous oxide ( NO ) synthase inhibitors , recombinant human interleukin-11 ( rhIL-11 ) , omega-3 fatty acid , mouse anti-human interleukin-6 receptor antibody ( MRA ) , [mitogen activated protein kinase (MAPK)] *inhibitors* , nuclear factor-kappa B (NF-kb) inhibitors , osteoprotegerin , and tumor necrosis factor antagonist ( ) are some of the therapeutic agents that have host modulation properties . Negative_regulation MAPK14 TNF 23518420 2777202 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and protein expression in the kidney , as well as *inhibiting* [p38MAPK] signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation MAPK14 TNF 24152910 2875257 It was found that thrombin down-regulates the HMGB1 mediated induction of both and IL-6 and *inhibits* the activation of both p38 [MAPK] and NF-?B in HUVECs pretreated with PC . Negative_regulation MAPK14 TNF 8665940 368988 Low concentrations ( 2 nM ) of okadaic acid , a serine/threonine phosphatase inhibitor , prevented *induced* inhibition of [MAPK] and restored insulin 's effect on MAPK activity , while orthovanadate ( a tyrosine phosphatase inhibitor ) , inhibitor 2 ( phosphatase-1 inhibitor ) and FK506 ( phosphatase-2B inhibitor ) were ineffective . Negative_regulation MAPK15 ANGPT1 24308939 2877788 The functional roles of DUSPs in *induced* regulation of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Negative_regulation MAPK15 ARSA 18563667 1952775 *inhibited* p38 [MAPK] but not ERK1/2 phosphorylation in washed platelets . Negative_regulation MAPK15 CCND1 19369047 2258041 We propose that breast cancer cell proliferation is inhibited by DHA through proteasome dependent degradation of ERalpha , reduced expression and *inhibition* of [MAPK] signaling . Negative_regulation MAPK15 CCND1 20113529 2213146 In contrast , focal adhesion/actin cytoskeleton , [MAPK] and NF B signaling appeared to characterize the target genes and their interacting proteins in *suppressed* PANC1 cells . Negative_regulation MAPK15 EPHB2 15810889 1392148 Thus , [MAPK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation MAPK15 EPHB2 15910808 1412146 The [MAPK/extracellular] signal regulated protein kinase ( ) kinase *inhibitor* , PD098059 ( 2'-amino-3'-methoxyflavone ) , significantly inhibited basal tone in a dose dependent manner . Negative_regulation MAPK15 EPHB2 16291589 1525985 TCCM treatment activated p38 [mitogen activated protein kinase (MAPK)] and Janus kinase (JNK) but *inhibited* . Negative_regulation MAPK15 EPHB2 16291589 1526018 Thus , our results suggested that tumor induced p38 [MAPK] activation and *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation MAPK15 EPHB2 17615677 1769051 We conclude that activation and p38 [MAPK] *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation MAPK15 EPHB2 18048804 1882896 No significant effects on HO-1 induction were observed with the pretreatment of [mitogen activated protein kinase] pathway *inhibitors* PD98059 ( ) , SB203580 ( p38MAPK ) and JNKi , and conventional and atypical PKC inhibitors . Negative_regulation MAPK15 EPHB2 18567920 1952834 CypA induced nuclear factor kappaB (NF-kappaB) activity for MMP-9 transcription were strongly blocked by extracellular signal regulated kinase ( ) , c-Jun amino terminal kinase (JNK) inhibitors ( U0126 and SP600125 , respectively ) , but not by p38 [mitogen activated protein kinase (MAPK)] *inhibitors* ( SB203580 ) . Negative_regulation MAPK15 EPHB2 19180563 2049261 Activated *suppressed* p38 [MAPK] activation and Fas/FasL protein expression . Negative_regulation MAPK15 EPHB2 19428337 2076996 Histological examination of lung tissues revealed that [MAPK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation MAPK15 EPHB2 20881039 2347113 Extracellular signal regulated receptor kinase ( ) and p38 [mitogen activated protein kinase] *inhibitors* ( U0126 and SB203580 ) were sufficient to block Nup hyperphosphorylation in EMCV infected or L-expressing cells . Negative_regulation MAPK15 EPHB2 21323644 2447655 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) signalling . Negative_regulation MAPK15 EPHB2 21663947 2459738 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation MAPK15 EPHB2 22129743 2515069 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 [mitogen activated protein kinase (MAPK)] and Akt phosphorylation , but in contrast , *inhibited* that of ( 1/2 ) . Negative_regulation MAPK15 EPHB2 22521802 2630847 Overexpression of the signaling protein Smad3 *enhanced* TGF-ß induced activation of ERK [MAPK] , whereas inhibition of Smad3 with a siRNA blocked MAPK phosphorylation in response to TGF-ß . Negative_regulation MAPK15 FAS 15669079 1382139 Concurrently , blockade drastically *activated* [MAPK] and promoted further a prominent accumulation of HIF-1alpha in Her-2/neu overexpressors . Negative_regulation MAPK15 FHL1 23456229 2781794 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Negative_regulation MAPK15 FUT4 20506505 2307903 Results show that overexpression of *increases* the phosphorylation of ERK1/2 , p38 [MAPK] , and PI3K/Akt . Negative_regulation MAPK15 HBEGF 19048624 2023698 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked MAPK signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 [MAPK] , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Negative_regulation MAPK15 HBEGF 19919524 2166797 Western blot analysis showed *prevents* ethanol from altering [MAPK] phosphorylation . Negative_regulation MAPK15 IL1B 12388337 1031315 CO treatment inhibited induced ERK1/2 activation but did not *inhibit* JNK and p38 [MAPK] . Negative_regulation MAPK15 IL1B 16718462 1584813 A synthetic peptide , C3d , reported to bind NCAM , did not activate [MAPK] or Akt as reported in neurons but *inhibited* induced MAPK activity , thereby mimicking the effect of SU5402 . Negative_regulation MAPK15 IL1B 18669445 1973071 DPML significantly inhibited tumor necrosis factor alpha , , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 [mitogen activated protein kinase] activation in the lung . Negative_regulation MAPK15 IL1B 19214751 2071793 triggered the activation of p38 and ERK1/2 ( p44/42) MAP kinase (MAPK) signaling pathways , but WIN55,212-2 mainly *inhibited* p38 [MAPK] phosphorylation . Negative_regulation MAPK15 LBP 19010986 2029054 and sCD14 *inhibited* the nontypeable Haemophilus influenzae ( NTHi ) -dependent secretion of IL-8 and the activation of NF-kappaB and p38 [mitogen activated protein kinase] signalling pathways but they increased the internalisation of NTHi by airway epithelial cells . Negative_regulation MAPK15 MAP2K6 11237743 790189 The [MAPK] kinase ( ) *inhibitor* , PD98059 , blocked GSA stimulated MAPK activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Negative_regulation MAPK15 MAP2K6 11258898 795470 T ( 4 ) -induced nuclear complexing of p53 and MAPK was inhibited by PD 98059 ( PD ) and U0126 , two [MAPK] kinase ( ) *inhibitors* , and was absent in cells treated with MEK antisense oligonucleotide and in dominant negative Ras cells . Negative_regulation MAPK15 MAP2K6 11304531 826779 The activation of p38 [MAPK] by Galpha ( q ) and Gbetagamma was *blocked* by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Negative_regulation MAPK15 MAP2K6 11399487 824113 The role of MAPK activation on GPalpha , FSHbeta and LHbeta gene expression was determined by administration of [MAPK-kinase] ( ) *inhibitor* ( PD98059 ; Negative_regulation MAPK15 MAP2K6 11744690 915745 Furthermore , the activation of p38 [MAPK] caused by overexpressing active RasVHa could not be inhibited using dominant negative mutants of MyD88 , IRAK , or IRAK-2 , or TRAF6 , but could be *inhibited* by dominant negative MKK3 or . Negative_regulation MAPK15 MAP2K6 11787422 891811 Indeed the [MAPK] kinase ( = ) *inhibitor* PD98059 inhibits the activation of parasite MAPK , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Negative_regulation MAPK15 MAP2K6 12649265 1080034 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant or p38beta2 MAPK *inhibited* interleukin-1beta induced p38 [MAPK] activation , COX-2 gene expression , and PGE2 release . Negative_regulation MAPK15 MAP2K6 12738672 1119415 Blocking the *activation* of p44/42 [mitogen activated protein kinase (MAPK)] by the specific mitogen induced extracellular kinase ( ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAPK15 MAP2K6 15284289 1277885 In contrast , a [mitogen activated protein (MAP) kinase/extracellular] signal regulated kinase ( ERK ) kinase ( ) /ERK *inhibitor* , PD98059 , completely abrogated the effect of high glucose . Negative_regulation MAPK15 MAP2K6 19606165 2105683 Overexpression of , a kinase upstream of p38 MAPK , *increased* phosphorylation of p38 [MAPK] and attenuated t-BOOH induced ARPE-19 cell death by 16 % . Negative_regulation MAPK15 MAP2K6 19915797 2197768 We confirmed the interaction between phospho-p38 and MAP4 using immunoprecipitation and found that SB203580 , a [p38/MAPK] *inhibitor* , increases and ( Glu ) overexpression decreases hypoxic cell viability . Negative_regulation MAPK15 MAP2K6 21323644 2447661 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAPK15 MAP2K6 22920673 2710153 We next analysed the effects of inhibiting signalling downstream of Ras , by specific *inhibitors* of [p38MAPK] , PI3-K or , on reoviral killing examined by MTT assay . Negative_regulation MAPK15 MAP2K6 23174698 2735846 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . inhibitor , U0126 completely blocked PKA inhibition *induced* [MAPK] activation and GVBD . Negative_regulation MAPK15 MUC16 22977714 2674031 Rottlerin ( PKCd inhibitor ) inhibited PMA induced expression , and also *inhibited* the phosphorylation of activated p38 [MAPK] by PMA . Negative_regulation MAPK15 PECAM1 19096001 2036109 These findings reveal that [p38MAPK] phosphorylation and platelet activation by LDL are *suppressed* by two mechanisms : ( 1 ) short activation of , and ( 2 ) prolonged activation of SHP-1 and SHP-2 . Negative_regulation MAPK15 PLAU 11606583 888437 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 [MAPK] and *inhibited* cell associated expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation MAPK15 PLAU 23615713 2804726 In addition , avß6 integrin *induced* the phosphorylation of p38 [MAPK] and PI3 K/Akt , contributing to the up-regulation of uPA , as treatment with the specific inhibitor for p38 mitogen activated protein kinases (MAPK) ( SB203580 ) or phosphatidylinositol 3-kinase (PI3 K)/Akt ( LY294002 ) strikingly abrogated expression . Negative_regulation MAPK15 RGS16 11602604 888197 These data suggest that tyrosine phosphorylation regulates RGS16 function and that EGFR may potentially *inhibit* Galpha ( i ) -dependent [MAPK] activation in a feedback loop by enhancing activity through tyrosine phosphorylation . Negative_regulation MAPK15 S100B 19961838 2199378 Albumin activated ERK1/2 , p38 [MAPK] and JNK signaling pathways in astrocytes , and *induced* the production of interleukin (IL)-1beta , inducible nitric oxide (NO) synthase , the NO metabolite nitrite , and the chemokine CX3CL1 while reducing the level of . Negative_regulation MAPK15 SPHK1 22684547 2705917 increased the constitutive expression of extracellular signal regulated kinase1/2 ( ERK1/2 ) but *reduced* the constitutive expression of p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK15 TCN1 23018889 2720252 Furthermore , whereas Compound C ( an AMPK inhibitor ) , AMPK-DN ( AMPK-dominant negative ) mutant , and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA *inhibited* the 8-Cl-cAMP- and AICAR mediated phosphorylation of AMPK and p38 [MAPK] . Negative_regulation MAPK15 TNF 10657669 664197 When KC was instilled as a proinflammatory stimulus , neutrophil accumulation was significantly decreased by p38 [MAPK] *inhibition* independent of or LPS . Negative_regulation MAPK15 TNF 12297293 991240 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Negative_regulation MAPK15 TNF 14729457 1198457 Among other cellular responses , *induces* different forms of cell death and the activation of the p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK15 TNF 15015934 1251066 Stimulation of human skin fibroblasts or articular chondrocytes with IL-1 or in the presence of HC-gp39 *resulted* in a marked reduction of both p38 [mitogen activated protein kinase] and stress activated protein kinase/Jun N-terminal kinase phosphorylation , whereas nuclear translocation of nuclear factor kappaB proceeded unimpeded . Negative_regulation MAPK15 TNF 15519192 1328831 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as TNFalpha production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 [MAPK] activation . Negative_regulation MAPK15 TNF 15763380 1383450 Furthermore , pretreatment with oxymatrine significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet-to-dry weight ratio , decreases in serum level and *inhibition* of phosphorylated p38 [MAPK] . Negative_regulation MAPK15 TNF 15952594 1421638 Pretreatment of EGCG significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet to dry weight ratio , decreased of level in serum and *inhibition* of phosphorylation of p38 [MAPK] . Negative_regulation MAPK15 TNF 17189827 1680097 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Negative_regulation MAPK15 TNF 17214640 1681792 Roxithromycin significantly inhibited induced c-Jun N-terminal kinase activation ( JNP ) and marginally *inhibited* extracellular signal regulated kinase ( ERK ) 1/2 activation , but not p38 [mitogen activated protein kinase] activation . Negative_regulation MAPK15 TNF 17438131 1742706 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Negative_regulation MAPK15 TNF 19086324 2000269 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 [MAPK] and NF-kappaB activities , and then overexpression , thus alleviating the inflammatory reaction . Negative_regulation MAPK15 TNF 19118509 2004807 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and and *inhibited* the phosphorylation of Akt , PKCdelta and p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK15 TNF 19450605 2096912 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 [MAPK] and *inhibited* cardiac expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation MAPK15 TNF 21147093 2378252 LPS induced phosphorylation of I?Ba and p38 [MAPK] was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation MAPK15 TNF 23056531 2685392 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit a ( TNF-a production in cultured macrophages ) and in vitro [MAPK] p38a *inhibition* . Negative_regulation MAPK15 TNF 23066265 2685762 Doxycycline , nonsteroidal anti-inflammatory drugs ( NSAIDs ) , bisphosphonates , nitrous oxide ( NO ) synthase inhibitors , recombinant human interleukin-11 ( rhIL-11 ) , omega-3 fatty acid , mouse anti-human interleukin-6 receptor antibody ( MRA ) , [mitogen activated protein kinase (MAPK)] *inhibitors* , nuclear factor-kappa B (NF-kb) inhibitors , osteoprotegerin , and tumor necrosis factor antagonist ( ) are some of the therapeutic agents that have host modulation properties . Negative_regulation MAPK15 TNF 23518420 2777196 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and protein expression in the kidney , as well as *inhibiting* [p38MAPK] signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation MAPK15 TNF 24152910 2875226 It was found that thrombin down-regulates the HMGB1 mediated induction of both and IL-6 and *inhibits* the activation of both p38 [MAPK] and NF-?B in HUVECs pretreated with PC . Negative_regulation MAPK15 TNF 8665940 368982 Low concentrations ( 2 nM ) of okadaic acid , a serine/threonine phosphatase inhibitor , prevented *induced* inhibition of [MAPK] and restored insulin 's effect on MAPK activity , while orthovanadate ( a tyrosine phosphatase inhibitor ) , inhibitor 2 ( phosphatase-1 inhibitor ) and FK506 ( phosphatase-2B inhibitor ) were ineffective . Negative_regulation MAPK3 ANGPT1 24308939 2877795 The functional roles of DUSPs in *induced* regulation of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Negative_regulation MAPK3 ARSA 12624303 1066607 strongly *inhibited* this [ERK1/2] activation . Negative_regulation MAPK3 ARSA 18563667 1952782 *inhibited* p38 [MAPK] but not ERK1/2 phosphorylation in washed platelets . Negative_regulation MAPK3 CCND1 19369047 2258048 We propose that breast cancer cell proliferation is inhibited by DHA through proteasome dependent degradation of ERalpha , reduced expression and *inhibition* of [MAPK] signaling . Negative_regulation MAPK3 CCND1 20113529 2213153 In contrast , focal adhesion/actin cytoskeleton , [MAPK] and NF B signaling appeared to characterize the target genes and their interacting proteins in *suppressed* PANC1 cells . Negative_regulation MAPK3 CCND1 23237355 2711150 Essential oil activated the caspase dependent apoptotic pathway , *induced* a rapid and transient activation of Akt and [Erk1/2] , and suppressed levels of expression in cultured pancreatic cancer cells . Negative_regulation MAPK3 CCND1 24397737 2917450 Lycopene *induced* strong and sustained activation of the [ERK1/2] , with concomitant suppression and p21 upregulation in these three cell lines . Negative_regulation MAPK3 EFNB1 24098442 2852229 TNF-a induced activation of [extracellular signal regulated kinase 1/2] ( ERK1/2 ) was *reduced* by . Negative_regulation MAPK3 EPHB2 15810889 1392168 Thus , [MAPK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation MAPK3 EPHB2 15910808 1412153 The [MAPK/extracellular] signal regulated protein kinase ( ) kinase *inhibitor* , PD098059 ( 2'-amino-3'-methoxyflavone ) , significantly inhibited basal tone in a dose dependent manner . Negative_regulation MAPK3 EPHB2 16291589 1526011 TCCM treatment activated p38 [mitogen activated protein kinase (MAPK)] and Janus kinase (JNK) but *inhibited* . Negative_regulation MAPK3 EPHB2 16291589 1526039 Thus , our results suggested that tumor induced p38 [MAPK] activation and *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation MAPK3 EPHB2 17207579 1695788 We have previously reported that in an in vitro model of oxidative stress in immature cortical neuronal cultures , the inhibition of phosphatase activity *contributes* to [ERK1/2] activation and subsequent neuronal toxicity . Negative_regulation MAPK3 EPHB2 17615677 1769079 We conclude that activation and p38 [MAPK] *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation MAPK3 EPHB2 18048804 1882903 No significant effects on HO-1 induction were observed with the pretreatment of [mitogen activated protein kinase] pathway *inhibitors* PD98059 ( ) , SB203580 ( p38MAPK ) and JNKi , and conventional and atypical PKC inhibitors . Negative_regulation MAPK3 EPHB2 18567920 1952841 CypA induced nuclear factor kappaB (NF-kappaB) activity for MMP-9 transcription were strongly blocked by extracellular signal regulated kinase ( ) , c-Jun amino terminal kinase (JNK) inhibitors ( U0126 and SP600125 , respectively ) , but not by p38 [mitogen activated protein kinase (MAPK)] *inhibitors* ( SB203580 ) . Negative_regulation MAPK3 EPHB2 19180563 2049269 Activated *suppressed* p38 [MAPK] activation and Fas/FasL protein expression . Negative_regulation MAPK3 EPHB2 19428337 2077016 Histological examination of lung tissues revealed that [MAPK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation MAPK3 EPHB2 20177944 2236684 and PD98059 , [extracellular signal regulated kinase 1/2] ( ) *inhibitor* , were administered for 10 min before ischemia and throughout the reperfusion period in POST ( POST + LY , POST + PD ) . Negative_regulation MAPK3 EPHB2 20215560 2259583 PAR1 effects on [ERK1/2] phosphorylation and cell migration were *blocked* both by pertussis toxin and by the mitogen activated protein kinase inhibitor [ 1,4-diamino-2,3-dicyano-1,4-bis ( methylthio ) butadiene ( U0126 ) ] , whereas PAR2 effects were only blocked by U0126 . Negative_regulation MAPK3 EPHB2 20427483 2262555 Furthermore , this increase was completely inhibited by an inhibitor , PD98059 , and phosphorylated [ERK1/2] was significantly *increased* after 30 min incubation with TZ . Negative_regulation MAPK3 EPHB2 20881039 2347120 Extracellular signal regulated receptor kinase ( ) and p38 [mitogen activated protein kinase] *inhibitors* ( U0126 and SB203580 ) were sufficient to block Nup hyperphosphorylation in EMCV infected or L-expressing cells . Negative_regulation MAPK3 EPHB2 21323644 2447815 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) signalling . Negative_regulation MAPK3 EPHB2 21503959 2463732 ATP induced the phosphorylation of [ERK1/2] , but the inhibitors , U0126 and PD9809 , did not *regulate* the inhibition of cell proliferation induced by ATP . Negative_regulation MAPK3 EPHB2 21663947 2459774 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation MAPK3 EPHB2 22129743 2515095 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 [mitogen activated protein kinase (MAPK)] and Akt phosphorylation , but in contrast , *inhibited* that of ( 1/2 ) . Negative_regulation MAPK3 EPHB2 22521802 2630861 Overexpression of the signaling protein Smad3 *enhanced* TGF-ß induced activation of ERK [MAPK] , whereas inhibition of Smad3 with a siRNA blocked MAPK phosphorylation in response to TGF-ß . Negative_regulation MAPK3 EPHB2 23416149 2759875 COA-Cl increased levels in a dose dependent manner and COA-Cl induced neuroprotection and [ERK1/2] activation was *inhibited* by suramin or PD98059 . Negative_regulation MAPK3 EPHB2 23589880 2778654 Because interference with ERK ( Thr188 ) phosphorylation ( i ) inhibits pathological hypertrophy and ( ii ) does not *impair* antiapoptotic [ERK1/2] signaling and because ( Thr188 ) phosphorylation shows strong prevalence for aortic stenosis patients with rapidly progressing course , we conclude that interference with ERK ( Thr188 ) phosphorylation offers the possibility to selectively address pathological types of cardiac hypertrophy . Negative_regulation MAPK3 F2R 20215560 2259580 Both receptors stimulated extracellular signal regulated kinase ( [ERK) 1/2] phosphorylation , but only *inhibited* adenylyl cyclase activity , and pertussis toxin blocked PAR1 effects on both adenylyl cyclase and ERK1/2 signaling . Negative_regulation MAPK3 FAS 15669079 1382147 Concurrently , blockade drastically *activated* [MAPK] and promoted further a prominent accumulation of HIF-1alpha in Her-2/neu overexpressors . Negative_regulation MAPK3 FHL1 23456229 2781803 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Negative_regulation MAPK3 FUT4 20506505 2307913 Results show that overexpression of *increases* the phosphorylation of ERK1/2 , p38 [MAPK] , and PI3K/Akt . Negative_regulation MAPK3 HBEGF 19048624 2023705 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked MAPK signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 [MAPK] , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Negative_regulation MAPK3 HBEGF 19919524 2166804 Western blot analysis showed *prevents* ethanol from altering [MAPK] phosphorylation . Negative_regulation MAPK3 IGFBP1 23981674 2885316 , similarly as echistatin and studied inhibitors , *contributed* to down-regulation of [ERK1/2] , Akt , mTOR expression and up-regulation of NF?B . Negative_regulation MAPK3 IGFBP1 24086495 2847872 Treatment with the ERK1/2 inhibitor , U0126 , significantly decreased the expression of the known decidualization marker genes , and PRL as well as *inhibited* the induction of known [ERK1/2] target genes ; Negative_regulation MAPK3 IL1B 12388337 1031330 CO treatment inhibited induced ERK1/2 activation but did not *inhibit* JNK and p38 [MAPK] . Negative_regulation MAPK3 IL1B 15031635 1183840 CQ reduced mRNA expression and strongly *inhibited* phosphorylation of mitogen activated protein kinase (MAPK) p38 , and to a lesser extent c-Jun N-terminal kinase and [extracellular signal regulated kinase 1/2] . Negative_regulation MAPK3 IL1B 16310170 1502950 *induced* apoptosis through adenylyl cyclase and [ERK1/2] inhibition in primary cultured thyroid cells . Negative_regulation MAPK3 IL1B 16718462 1584883 A synthetic peptide , C3d , reported to bind NCAM , did not activate [MAPK] or Akt as reported in neurons but *inhibited* induced MAPK activity , thereby mimicking the effect of SU5402 . Negative_regulation MAPK3 IL1B 16987994 1692465 IL-1beta activated [ERK1/2] , JNKs , and protein kinase C ( PKC ) , specifically PKCalpha/beta ( 1 ) , and inhibition of these cascades partially *inhibited* stimulated increases in MMP-2 . Negative_regulation MAPK3 IL1B 18669445 1973100 DPML significantly inhibited tumor necrosis factor alpha , , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 [mitogen activated protein kinase] activation in the lung . Negative_regulation MAPK3 IL1B 19214751 2071819 triggered the activation of p38 and ERK1/2 ( p44/42) MAP kinase (MAPK) signaling pathways , but WIN55,212-2 mainly *inhibited* p38 [MAPK] phosphorylation . Negative_regulation MAPK3 LBP 19010986 2029062 and sCD14 *inhibited* the nontypeable Haemophilus influenzae ( NTHi ) -dependent secretion of IL-8 and the activation of NF-kappaB and p38 [mitogen activated protein kinase] signalling pathways but they increased the internalisation of NTHi by airway epithelial cells . Negative_regulation MAPK3 MAP2K6 11237743 790238 The [MAPK] kinase ( ) *inhibitor* , PD98059 , blocked GSA stimulated MAPK activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Negative_regulation MAPK3 MAP2K6 11258898 795519 T ( 4 ) -induced nuclear complexing of p53 and MAPK was inhibited by PD 98059 ( PD ) and U0126 , two [MAPK] kinase ( ) *inhibitors* , and was absent in cells treated with MEK antisense oligonucleotide and in dominant negative Ras cells . Negative_regulation MAPK3 MAP2K6 11304531 826800 The activation of p38 [MAPK] by Galpha ( q ) and Gbetagamma was *blocked* by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Negative_regulation MAPK3 MAP2K6 11399487 824162 The role of MAPK activation on GPalpha , FSHbeta and LHbeta gene expression was determined by administration of [MAPK-kinase] ( ) *inhibitor* ( PD98059 ; Negative_regulation MAPK3 MAP2K6 11744690 915759 Furthermore , the activation of p38 [MAPK] caused by overexpressing active RasVHa could not be inhibited using dominant negative mutants of MyD88 , IRAK , or IRAK-2 , or TRAF6 , but could be *inhibited* by dominant negative MKK3 or . Negative_regulation MAPK3 MAP2K6 11787422 891860 Indeed the [MAPK] kinase ( = ) *inhibitor* PD98059 inhibits the activation of parasite MAPK , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Negative_regulation MAPK3 MAP2K6 12649265 1080041 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant or p38beta2 MAPK *inhibited* interleukin-1beta induced p38 [MAPK] activation , COX-2 gene expression , and PGE2 release . Negative_regulation MAPK3 MAP2K6 12738672 1119555 Blocking the *activation* of p44/42 [mitogen activated protein kinase (MAPK)] by the specific mitogen induced extracellular kinase ( ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAPK3 MAP2K6 12871849 1185349 Both the effects of HNP1-3 on wound closure and [ERK1/2] *activation* were blocked by specific inhibitors of the mitogen activated protein kinase kinase , whereas inhibitors of epidermal growth factor receptor tyrosine kinase , phosphatidylinositol 3-kinase , and Src did block defensin enhanced wound closure but not ERK1/2 activation . Negative_regulation MAPK3 MAP2K6 15284289 1277941 In contrast , a [mitogen activated protein (MAP) kinase/extracellular] signal regulated kinase ( ERK ) kinase ( ) /ERK *inhibitor* , PD98059 , completely abrogated the effect of high glucose . Negative_regulation MAPK3 MAP2K6 15737734 1378670 Axons protected by MG132 displayed persistent phosphorylation of [Erk1/2] , and pharmacological inhibition of activity with U0126 ( 50 microM ) *restored* rapid axonal degeneration . Negative_regulation MAPK3 MAP2K6 17027231 1641593 Moreover , the ( mitogen activated protein kinase/extracellular signal regulated kinase-kinase ) inhibitor suppressed the allicin induced inhibition of apoptosis in a depleted nutritional state and allicin *increased* the level of [ERK1/2] phosphorylation . Negative_regulation MAPK3 MAP2K6 19606165 2105690 Overexpression of , a kinase upstream of p38 MAPK , *increased* phosphorylation of p38 [MAPK] and attenuated t-BOOH induced ARPE-19 cell death by 16 % . Negative_regulation MAPK3 MAP2K6 19915797 2197775 We confirmed the interaction between phospho-p38 and MAP4 using immunoprecipitation and found that SB203580 , a [p38/MAPK] *inhibitor* , increases and ( Glu ) overexpression decreases hypoxic cell viability . Negative_regulation MAPK3 MAP2K6 20215560 2259589 PAR1 effects on [ERK1/2] phosphorylation and cell migration were *blocked* both by pertussis toxin and by the inhibitor [ 1,4-diamino-2,3-dicyano-1,4-bis ( methylthio ) butadiene ( U0126 ) ] , whereas PAR2 effects were only blocked by U0126 . Negative_regulation MAPK3 MAP2K6 21323644 2447821 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAPK3 MAP2K6 22920673 2710225 We next analysed the effects of inhibiting signalling downstream of Ras , by specific *inhibitors* of [p38MAPK] , PI3-K or , on reoviral killing examined by MTT assay . Negative_regulation MAPK3 MAP2K6 23174698 2735986 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . inhibitor , U0126 completely blocked PKA inhibition *induced* [MAPK] activation and GVBD . Negative_regulation MAPK3 MAP2K6 9144515 429650 In the *presence* of the inhibitor , PD 098059 , phagocytosis was reduced by approximately 50 % , while [ERK1] and ERK2 activity was reduced by 85 to 90 % . Negative_regulation MAPK3 MAP2K6 9582373 504246 However , elevated activity *attenuated* subsequent stimulation of [Erk1] and Erk2 by serum . Negative_regulation MAPK3 MUC16 22977714 2674038 Rottlerin ( PKCd inhibitor ) inhibited PMA induced expression , and also *inhibited* the phosphorylation of activated p38 [MAPK] by PMA . Negative_regulation MAPK3 PCSK9 22593575 2619798 expression was *induced* by inhibition of [ERK1/2] activity but inhibited by ERK1/2 activation . Negative_regulation MAPK3 PECAM1 15985432 1441181 Tie2 and expression decreased > 80 % after siRNA treatment , and flow stimulated phosphorylation of [ERK1/2] , Akt , and endothelial nitric oxide synthase was significantly *inhibited* by Tie2 and PECAM1 siRNA . Negative_regulation MAPK3 PECAM1 18672896 1948192 Activation of [ERK1/2] by bradykinin in HUVEC is *enhanced* when expression is inhibited by transfection of small interference RNA against PECAM-1 . Negative_regulation MAPK3 PECAM1 19096001 2036157 These findings reveal that [p38MAPK] phosphorylation and platelet activation by LDL are *suppressed* by two mechanisms : ( 1 ) short activation of , and ( 2 ) prolonged activation of SHP-1 and SHP-2 . Negative_regulation MAPK3 PLAT 24129569 2875081 Lactoferrin functioned as an LRP1 signaling antagonist , inhibiting Trk receptor phosphorylation and [ERK1/2] activation in *response* to . Negative_regulation MAPK3 PLAU 11606583 888444 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 [MAPK] and *inhibited* cell associated expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation MAPK3 PLAU 23615713 2804736 In addition , avß6 integrin *induced* the phosphorylation of p38 [MAPK] and PI3 K/Akt , contributing to the up-regulation of uPA , as treatment with the specific inhibitor for p38 mitogen activated protein kinases (MAPK) ( SB203580 ) or phosphatidylinositol 3-kinase (PI3 K)/Akt ( LY294002 ) strikingly abrogated expression . Negative_regulation MAPK3 RASD1 15913563 1412593 however , *blocked* acute D ( 2L ) receptor mediated activation of [ERK 1/2] by approximately 50 % . Negative_regulation MAPK3 RGS16 11602604 888211 These data suggest that tyrosine phosphorylation regulates RGS16 function and that EGFR may potentially *inhibit* Galpha ( i ) -dependent [MAPK] activation in a feedback loop by enhancing activity through tyrosine phosphorylation . Negative_regulation MAPK3 S100B 19961838 2199386 Albumin activated ERK1/2 , p38 [MAPK] and JNK signaling pathways in astrocytes , and *induced* the production of interleukin (IL)-1beta , inducible nitric oxide (NO) synthase , the NO metabolite nitrite , and the chemokine CX3CL1 while reducing the level of . Negative_regulation MAPK3 S100B 21130124 2414000 Moreover , *reduces* myoblast apoptosis in an [MEK-ERK1/2] , Akt , JNK , and NF-?B dependent manner . Negative_regulation MAPK3 SPHK1 15863357 1401133 The overexpression of wild-type , but not dominant negative SPHK1 , *resulted* in high basal levels of [ERK1/2] phosphorylation and stimulated granulocytic differentiation in HL60 cells . Negative_regulation MAPK3 SPHK1 15993704 1429714 Inhibition of SPHK-1 also did not affect EGF stimulated phosphorylation of PI-3 kinase , Akt , [ERK1/2] or p38 but inhibition of PI-3 kinase with a specific inhibitor LY294002 partly ( 40 % ) *inhibited* the EGF stimulated increase in activity . Negative_regulation MAPK3 SPHK1 22684547 2705924 increased the constitutive expression of extracellular signal regulated kinase1/2 ( ERK1/2 ) but *reduced* the constitutive expression of p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK3 TCN1 23018889 2720326 Furthermore , whereas Compound C ( an AMPK inhibitor ) , AMPK-DN ( AMPK-dominant negative ) mutant , and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA *inhibited* the 8-Cl-cAMP- and AICAR mediated phosphorylation of AMPK and p38 [MAPK] . Negative_regulation MAPK3 TLR7 18287072 1872514 However , when coupled with Sema6D , a ligand for Plexin-A1 , limited *resulted* in PDC-TREM mediated DAP12 dependent phosphorylation of phosphoinositide 3-kinase (PI3K) and [extracellular regulated kinase (Erk) 1/2] at 6-9 h , and IFN-alpha was produced . Negative_regulation MAPK3 TLR7 24259503 2892730 stimulation of TRAF5-deficient B cells did not affect cell survival , proliferation , or NF-?B activation but *resulted* in markedly enhanced phosphorylation of the MAPKs [ERK1/2] and JNK . Negative_regulation MAPK3 TNF 10657669 664225 When KC was instilled as a proinflammatory stimulus , neutrophil accumulation was significantly decreased by p38 [MAPK] *inhibition* independent of or LPS . Negative_regulation MAPK3 TNF 10764814 698918 In contrast , transiently *suppressed* insulin induced [ERK1/2] activation . Negative_regulation MAPK3 TNF 12297293 991247 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Negative_regulation MAPK3 TNF 14729457 1198464 Among other cellular responses , *induces* different forms of cell death and the activation of the p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK3 TNF 15015934 1251080 Stimulation of human skin fibroblasts or articular chondrocytes with IL-1 or in the presence of HC-gp39 *resulted* in a marked reduction of both p38 [mitogen activated protein kinase] and stress activated protein kinase/Jun N-terminal kinase phosphorylation , whereas nuclear translocation of nuclear factor kappaB proceeded unimpeded . Negative_regulation MAPK3 TNF 15519192 1328839 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial TNFalpha mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 [MAPK] activation . Negative_regulation MAPK3 TNF 15763380 1383457 Furthermore , pretreatment with oxymatrine significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet-to-dry weight ratio , decreases in serum level and *inhibition* of phosphorylated p38 [MAPK] . Negative_regulation MAPK3 TNF 15952594 1421645 Pretreatment of EGCG significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet to dry weight ratio , decreased of level in serum and *inhibition* of phosphorylation of p38 [MAPK] . Negative_regulation MAPK3 TNF 16574984 1568540 *attenuated* JAK2/STAT5 and [ERK1/2] phosphorylation and IGF-I and Spi 2.1 mRNA expression following GH stimulation . Negative_regulation MAPK3 TNF 17189827 1680113 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Negative_regulation MAPK3 TNF 17214640 1681822 Roxithromycin significantly inhibited induced c-Jun N-terminal kinase activation ( JNP ) and marginally *inhibited* extracellular signal regulated kinase ( ERK ) 1/2 activation , but not p38 [mitogen activated protein kinase] activation . Negative_regulation MAPK3 TNF 17264149 1696910 Disrupting signaling by TNF-alpha neutralizing antibody or knocking out TNF-alpha receptors *blocked* stretch activation of p38 , but not [ERK1/2] , JNK or AKT . Negative_regulation MAPK3 TNF 17438131 1742714 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Negative_regulation MAPK3 TNF 18330685 1904673 Furthermore , the *induced* decrease in the phosphorylation of [ERK1/2] was abolished by overexpression of SOCS-1 . Negative_regulation MAPK3 TNF 19086324 2000276 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 [MAPK] and NF-kappaB activities , and then overexpression , thus alleviating the inflammatory reaction . Negative_regulation MAPK3 TNF 19118509 2004853 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and and *inhibited* the phosphorylation of Akt , PKCdelta and p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK3 TNF 19450605 2096920 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 [MAPK] and *inhibited* cardiac expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation MAPK3 TNF 19808894 2187055 IkappaB kinase-(IKK)-beta inhibition prevented mitogen activated protein (MAP) kinase kinase ( MEK ) [/ERK1/2] activation in *response* to interleukin (IL)-1beta and but not insulin in 3T3-L1 and human adipocytes , suggesting that IKKbeta regulated a MAP kinase kinase kinase ( MAP3K ) involved in ERK1/2 activation induced by inflammatory cytokines . Negative_regulation MAPK3 TNF 21147093 2378299 LPS induced phosphorylation of I?Ba and p38 [MAPK] was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation MAPK3 TNF 21925494 2492122 The drug also reduced M. leprae induced production and *inhibited* p38 and [ERK1/2] activation . Negative_regulation MAPK3 TNF 22198506 2558717 MKP1 attenuates [ERK1/2] and p38 activation , *inhibits* myocardial expression , and improves cardiac function in endotoxemia . Negative_regulation MAPK3 TNF 22427564 2588229 BBR inhibited the expression of IL-6 , IL-8 , and MCP-1 remarkably at both protein and mRNA levels and down-regulated the phosphorylation of p38 , [ERK1/2] , and JNK upon *stimulation* with . Negative_regulation MAPK3 TNF 23056531 2685406 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit a ( TNF-a production in cultured macrophages ) and in vitro [MAPK] p38a *inhibition* . Negative_regulation MAPK3 TNF 23066265 2685769 Doxycycline , nonsteroidal anti-inflammatory drugs ( NSAIDs ) , bisphosphonates , nitrous oxide ( NO ) synthase inhibitors , recombinant human interleukin-11 ( rhIL-11 ) , omega-3 fatty acid , mouse anti-human interleukin-6 receptor antibody ( MRA ) , [mitogen activated protein kinase (MAPK)] *inhibitors* , nuclear factor-kappa B (NF-kb) inhibitors , osteoprotegerin , and tumor necrosis factor antagonist ( ) are some of the therapeutic agents that have host modulation properties . Negative_regulation MAPK3 TNF 23518420 2777203 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and protein expression in the kidney , as well as *inhibiting* [p38MAPK] signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation MAPK3 TNF 24152910 2875260 It was found that thrombin down-regulates the HMGB1 mediated induction of both and IL-6 and *inhibits* the activation of both p38 [MAPK] and NF-?B in HUVECs pretreated with PC . Negative_regulation MAPK3 TNF 8665940 368989 Low concentrations ( 2 nM ) of okadaic acid , a serine/threonine phosphatase inhibitor , prevented induced *inhibition* of [MAPK] and restored insulin 's effect on MAPK activity , while orthovanadate ( a tyrosine phosphatase inhibitor ) , inhibitor 2 ( phosphatase-1 inhibitor ) and FK506 ( phosphatase-2B inhibitor ) were ineffective . Negative_regulation MAPK3 TNF 9370349 464156 A comparable mediated *inhibition* of [p42/44 mitogen activated protein (MAP) kinase] activity was observed in 10 nM EGF stimulated cells . Negative_regulation MAPK4 ANGPT1 24308939 2877796 The functional roles of DUSPs in *induced* regulation of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Negative_regulation MAPK4 ARSA 18563667 1952783 *inhibited* p38 [MAPK] but not ERK1/2 phosphorylation in washed platelets . Negative_regulation MAPK4 CCND1 19369047 2258049 We propose that breast cancer cell proliferation is inhibited by DHA through proteasome dependent degradation of ERalpha , reduced expression and *inhibition* of [MAPK] signaling . Negative_regulation MAPK4 CCND1 20113529 2213154 In contrast , focal adhesion/actin cytoskeleton , [MAPK] and NF B signaling appeared to characterize the target genes and their interacting proteins in *suppressed* PANC1 cells . Negative_regulation MAPK4 EPHB2 15810889 1392169 Thus , [MAPK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation MAPK4 EPHB2 15910808 1412154 The [MAPK/extracellular] signal regulated protein kinase ( ) kinase *inhibitor* , PD098059 ( 2'-amino-3'-methoxyflavone ) , significantly inhibited basal tone in a dose dependent manner . Negative_regulation MAPK4 EPHB2 16291589 1526012 TCCM treatment activated p38 [mitogen activated protein kinase (MAPK)] and Janus kinase (JNK) but *inhibited* . Negative_regulation MAPK4 EPHB2 16291589 1526040 Thus , our results suggested that tumor induced p38 [MAPK] activation and *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation MAPK4 EPHB2 17615677 1769081 We conclude that activation and p38 [MAPK] *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation MAPK4 EPHB2 18048804 1882904 No significant effects on HO-1 induction were observed with the pretreatment of [mitogen activated protein kinase] pathway *inhibitors* PD98059 ( ) , SB203580 ( p38MAPK ) and JNKi , and conventional and atypical PKC inhibitors . Negative_regulation MAPK4 EPHB2 18567920 1952842 CypA induced nuclear factor kappaB (NF-kappaB) activity for MMP-9 transcription were strongly blocked by extracellular signal regulated kinase ( ) , c-Jun amino terminal kinase (JNK) inhibitors ( U0126 and SP600125 , respectively ) , but not by p38 [mitogen activated protein kinase (MAPK)] *inhibitors* ( SB203580 ) . Negative_regulation MAPK4 EPHB2 19180563 2049270 Activated *suppressed* p38 [MAPK] activation and Fas/FasL protein expression . Negative_regulation MAPK4 EPHB2 19428337 2077017 Histological examination of lung tissues revealed that [MAPK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation MAPK4 EPHB2 20881039 2347121 Extracellular signal regulated receptor kinase ( ) and p38 [mitogen activated protein kinase] *inhibitors* ( U0126 and SB203580 ) were sufficient to block Nup hyperphosphorylation in EMCV infected or L-expressing cells . Negative_regulation MAPK4 EPHB2 21323644 2447823 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) signalling . Negative_regulation MAPK4 EPHB2 21663947 2459777 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation MAPK4 EPHB2 22129743 2515096 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 [mitogen activated protein kinase (MAPK)] and Akt phosphorylation , but in contrast , *inhibited* that of ( 1/2 ) . Negative_regulation MAPK4 EPHB2 22521802 2630863 Overexpression of the signaling protein Smad3 *enhanced* TGF-ß induced activation of ERK [MAPK] , whereas inhibition of Smad3 with a siRNA blocked MAPK phosphorylation in response to TGF-ß . Negative_regulation MAPK4 FAS 15669079 1382148 Concurrently , blockade drastically *activated* [MAPK] and promoted further a prominent accumulation of HIF-1alpha in Her-2/neu overexpressors . Negative_regulation MAPK4 FHL1 23456229 2781804 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Negative_regulation MAPK4 FUT4 20506505 2307914 Results show that overexpression of *increases* the phosphorylation of ERK1/2 , p38 [MAPK] , and PI3K/Akt . Negative_regulation MAPK4 HBEGF 19048624 2023706 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked MAPK signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 [MAPK] , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Negative_regulation MAPK4 HBEGF 19919524 2166805 Western blot analysis showed *prevents* ethanol from altering [MAPK] phosphorylation . Negative_regulation MAPK4 IL1B 12388337 1031343 CO treatment inhibited induced ERK1/2 activation but did not *inhibit* JNK and p38 [MAPK] . Negative_regulation MAPK4 IL1B 16718462 1584887 A synthetic peptide , C3d , reported to bind NCAM , did not activate [MAPK] or Akt as reported in neurons but *inhibited* induced MAPK activity , thereby mimicking the effect of SU5402 . Negative_regulation MAPK4 IL1B 18669445 1973102 DPML significantly inhibited tumor necrosis factor alpha , , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 [mitogen activated protein kinase] activation in the lung . Negative_regulation MAPK4 IL1B 19214751 2071833 triggered the activation of p38 and ERK1/2 ( p44/42) MAP kinase (MAPK) signaling pathways , but WIN55,212-2 mainly *inhibited* p38 [MAPK] phosphorylation . Negative_regulation MAPK4 LBP 19010986 2029063 and sCD14 *inhibited* the nontypeable Haemophilus influenzae ( NTHi ) -dependent secretion of IL-8 and the activation of NF-kappaB and p38 [mitogen activated protein kinase] signalling pathways but they increased the internalisation of NTHi by airway epithelial cells . Negative_regulation MAPK4 MAP2K6 11237743 790245 The [MAPK] kinase ( ) *inhibitor* , PD98059 , blocked GSA stimulated MAPK activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Negative_regulation MAPK4 MAP2K6 11258898 795526 T ( 4 ) -induced nuclear complexing of p53 and MAPK was inhibited by PD 98059 ( PD ) and U0126 , two [MAPK] kinase ( ) *inhibitors* , and was absent in cells treated with MEK antisense oligonucleotide and in dominant negative Ras cells . Negative_regulation MAPK4 MAP2K6 11304531 826803 The activation of p38 [MAPK] by Galpha ( q ) and Gbetagamma was *blocked* by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Negative_regulation MAPK4 MAP2K6 11399487 824169 The role of MAPK activation on GPalpha , FSHbeta and LHbeta gene expression was determined by administration of [MAPK-kinase] ( ) *inhibitor* ( PD98059 ; Negative_regulation MAPK4 MAP2K6 11744690 915761 Furthermore , the activation of p38 [MAPK] caused by overexpressing active RasVHa could not be inhibited using dominant negative mutants of MyD88 , IRAK , or IRAK-2 , or TRAF6 , but could be *inhibited* by dominant negative MKK3 or . Negative_regulation MAPK4 MAP2K6 11787422 891867 Indeed the [MAPK] kinase ( = ) *inhibitor* PD98059 inhibits the activation of parasite MAPK , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Negative_regulation MAPK4 MAP2K6 12649265 1080042 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant or p38beta2 MAPK *inhibited* interleukin-1beta induced p38 [MAPK] activation , COX-2 gene expression , and PGE2 release . Negative_regulation MAPK4 MAP2K6 12738672 1119562 Blocking the *activation* of p44/42 [mitogen activated protein kinase (MAPK)] by the specific mitogen induced extracellular kinase ( ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAPK4 MAP2K6 15284289 1277948 In contrast , a [mitogen activated protein (MAP) kinase/extracellular] signal regulated kinase ( ERK ) kinase ( ) /ERK *inhibitor* , PD98059 , completely abrogated the effect of high glucose . Negative_regulation MAPK4 MAP2K6 19606165 2105691 Overexpression of , a kinase upstream of p38 MAPK , *increased* phosphorylation of p38 [MAPK] and attenuated t-BOOH induced ARPE-19 cell death by 16 % . Negative_regulation MAPK4 MAP2K6 19915797 2197776 We confirmed the interaction between phospho-p38 and MAP4 using immunoprecipitation and found that SB203580 , a [p38/MAPK] *inhibitor* , increases and ( Glu ) overexpression decreases hypoxic cell viability . Negative_regulation MAPK4 MAP2K6 21323644 2447829 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAPK4 MAP2K6 22920673 2710234 We next analysed the effects of inhibiting signalling downstream of Ras , by specific *inhibitors* of [p38MAPK] , PI3-K or , on reoviral killing examined by MTT assay . Negative_regulation MAPK4 MAP2K6 23174698 2735993 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . inhibitor , U0126 completely blocked PKA inhibition *induced* [MAPK] activation and GVBD . Negative_regulation MAPK4 MUC16 22977714 2674039 Rottlerin ( PKCd inhibitor ) inhibited PMA induced expression , and also *inhibited* the phosphorylation of activated p38 [MAPK] by PMA . Negative_regulation MAPK4 PECAM1 19096001 2036163 These findings reveal that [p38MAPK] phosphorylation and platelet activation by LDL are *suppressed* by two mechanisms : ( 1 ) short activation of , and ( 2 ) prolonged activation of SHP-1 and SHP-2 . Negative_regulation MAPK4 PLAU 11606583 888445 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 [MAPK] and *inhibited* cell associated expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation MAPK4 PLAU 23615713 2804737 In addition , avß6 integrin *induced* the phosphorylation of p38 [MAPK] and PI3 K/Akt , contributing to the up-regulation of uPA , as treatment with the specific inhibitor for p38 mitogen activated protein kinases (MAPK) ( SB203580 ) or phosphatidylinositol 3-kinase (PI3 K)/Akt ( LY294002 ) strikingly abrogated expression . Negative_regulation MAPK4 RGS16 11602604 888213 These data suggest that tyrosine phosphorylation regulates function and that EGFR may potentially *inhibit* Galpha ( i ) -dependent [MAPK] activation in a feedback loop by enhancing RGS16 activity through tyrosine phosphorylation . Negative_regulation MAPK4 S100B 19961838 2199387 Albumin activated ERK1/2 , p38 [MAPK] and JNK signaling pathways in astrocytes , and *induced* the production of interleukin (IL)-1beta , inducible nitric oxide (NO) synthase , the NO metabolite nitrite , and the chemokine CX3CL1 while reducing the level of . Negative_regulation MAPK4 SPHK1 22684547 2705925 increased the constitutive expression of extracellular signal regulated kinase1/2 ( ERK1/2 ) but *reduced* the constitutive expression of p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK4 TCN1 23018889 2720334 Furthermore , whereas Compound C ( an AMPK inhibitor ) , AMPK-DN ( AMPK-dominant negative ) mutant , and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA *inhibited* the 8-Cl-cAMP- and AICAR mediated phosphorylation of AMPK and p38 [MAPK] . Negative_regulation MAPK4 TNF 10657669 664227 When KC was instilled as a proinflammatory stimulus , neutrophil accumulation was significantly decreased by p38 [MAPK] *inhibition* independent of or LPS . Negative_regulation MAPK4 TNF 12297293 991248 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Negative_regulation MAPK4 TNF 14729457 1198465 Among other cellular responses , *induces* different forms of cell death and the activation of the p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK4 TNF 15015934 1251082 Stimulation of human skin fibroblasts or articular chondrocytes with IL-1 or in the presence of HC-gp39 *resulted* in a marked reduction of both p38 [mitogen activated protein kinase] and stress activated protein kinase/Jun N-terminal kinase phosphorylation , whereas nuclear translocation of nuclear factor kappaB proceeded unimpeded . Negative_regulation MAPK4 TNF 15519192 1328840 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as TNFalpha production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 [MAPK] activation . Negative_regulation MAPK4 TNF 15763380 1383458 Furthermore , pretreatment with oxymatrine significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet-to-dry weight ratio , decreases in serum level and *inhibition* of phosphorylated p38 [MAPK] . Negative_regulation MAPK4 TNF 15952594 1421646 Pretreatment of EGCG significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet to dry weight ratio , decreased of level in serum and *inhibition* of phosphorylation of p38 [MAPK] . Negative_regulation MAPK4 TNF 17189827 1680115 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Negative_regulation MAPK4 TNF 17214640 1681824 Roxithromycin significantly inhibited induced c-Jun N-terminal kinase activation ( JNP ) and marginally *inhibited* extracellular signal regulated kinase ( ERK ) 1/2 activation , but not p38 [mitogen activated protein kinase] activation . Negative_regulation MAPK4 TNF 17438131 1742715 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Negative_regulation MAPK4 TNF 19086324 2000277 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 [MAPK] and NF-kappaB activities , and then overexpression , thus alleviating the inflammatory reaction . Negative_regulation MAPK4 TNF 19118509 2004856 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and and *inhibited* the phosphorylation of Akt , PKCdelta and p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK4 TNF 19450605 2096921 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 [MAPK] and *inhibited* cardiac expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation MAPK4 TNF 21147093 2378302 LPS induced phosphorylation of I?Ba and p38 [MAPK] was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation MAPK4 TNF 23056531 2685408 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit a ( TNF-a production in cultured macrophages ) and in vitro [MAPK] p38a *inhibition* . Negative_regulation MAPK4 TNF 23066265 2685770 Doxycycline , nonsteroidal anti-inflammatory drugs ( NSAIDs ) , bisphosphonates , nitrous oxide ( NO ) synthase inhibitors , recombinant human interleukin-11 ( rhIL-11 ) , omega-3 fatty acid , mouse anti-human interleukin-6 receptor antibody ( MRA ) , [mitogen activated protein kinase (MAPK)] *inhibitors* , nuclear factor-kappa B (NF-kb) inhibitors , osteoprotegerin , and tumor necrosis factor antagonist ( ) are some of the therapeutic agents that have host modulation properties . Negative_regulation MAPK4 TNF 23518420 2777204 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and protein expression in the kidney , as well as *inhibiting* [p38MAPK] signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation MAPK4 TNF 24152910 2875263 It was found that thrombin down-regulates the HMGB1 mediated induction of both and IL-6 and *inhibits* the activation of both p38 [MAPK] and NF-?B in HUVECs pretreated with PC . Negative_regulation MAPK4 TNF 8665940 368990 Low concentrations ( 2 nM ) of okadaic acid , a serine/threonine phosphatase inhibitor , prevented *induced* inhibition of [MAPK] and restored insulin 's effect on MAPK activity , while orthovanadate ( a tyrosine phosphatase inhibitor ) , inhibitor 2 ( phosphatase-1 inhibitor ) and FK506 ( phosphatase-2B inhibitor ) were ineffective . Negative_regulation MAPK6 ANGPT1 24308939 2877797 The functional roles of DUSPs in *induced* regulation of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Negative_regulation MAPK6 ARSA 18563667 1952784 *inhibited* p38 [MAPK] but not ERK1/2 phosphorylation in washed platelets . Negative_regulation MAPK6 CCND1 19369047 2258050 We propose that breast cancer cell proliferation is inhibited by DHA through proteasome dependent degradation of ERalpha , reduced expression and *inhibition* of [MAPK] signaling . Negative_regulation MAPK6 CCND1 20113529 2213155 In contrast , focal adhesion/actin cytoskeleton , [MAPK] and NF B signaling appeared to characterize the target genes and their interacting proteins in *suppressed* PANC1 cells . Negative_regulation MAPK6 EPHB2 15810889 1392170 Thus , [MAPK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation MAPK6 EPHB2 15910808 1412155 The [MAPK/extracellular] signal regulated protein kinase ( ) kinase *inhibitor* , PD098059 ( 2'-amino-3'-methoxyflavone ) , significantly inhibited basal tone in a dose dependent manner . Negative_regulation MAPK6 EPHB2 16291589 1526013 TCCM treatment activated p38 [mitogen activated protein kinase (MAPK)] and Janus kinase (JNK) but *inhibited* . Negative_regulation MAPK6 EPHB2 16291589 1526041 Thus , our results suggested that tumor induced p38 [MAPK] activation and *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation MAPK6 EPHB2 17615677 1769083 We conclude that activation and p38 [MAPK] *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation MAPK6 EPHB2 18048804 1882905 No significant effects on HO-1 induction were observed with the pretreatment of [mitogen activated protein kinase] pathway *inhibitors* PD98059 ( ) , SB203580 ( p38MAPK ) and JNKi , and conventional and atypical PKC inhibitors . Negative_regulation MAPK6 EPHB2 18567920 1952843 CypA induced nuclear factor kappaB (NF-kappaB) activity for MMP-9 transcription were strongly blocked by extracellular signal regulated kinase ( ) , c-Jun amino terminal kinase (JNK) inhibitors ( U0126 and SP600125 , respectively ) , but not by p38 [mitogen activated protein kinase (MAPK)] *inhibitors* ( SB203580 ) . Negative_regulation MAPK6 EPHB2 19180563 2049271 Activated *suppressed* p38 [MAPK] activation and Fas/FasL protein expression . Negative_regulation MAPK6 EPHB2 19428337 2077018 Histological examination of lung tissues revealed that [MAPK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation MAPK6 EPHB2 20881039 2347122 Extracellular signal regulated receptor kinase ( ) and p38 [mitogen activated protein kinase] *inhibitors* ( U0126 and SB203580 ) were sufficient to block Nup hyperphosphorylation in EMCV infected or L-expressing cells . Negative_regulation MAPK6 EPHB2 21323644 2447831 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) signalling . Negative_regulation MAPK6 EPHB2 21663947 2459780 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation MAPK6 EPHB2 22129743 2515097 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 [mitogen activated protein kinase (MAPK)] and Akt phosphorylation , but in contrast , *inhibited* that of ( 1/2 ) . Negative_regulation MAPK6 EPHB2 22521802 2630865 Overexpression of the signaling protein Smad3 *enhanced* TGF-ß induced activation of ERK [MAPK] , whereas inhibition of Smad3 with a siRNA blocked MAPK phosphorylation in response to TGF-ß . Negative_regulation MAPK6 FAS 15669079 1382149 Concurrently , blockade drastically *activated* [MAPK] and promoted further a prominent accumulation of HIF-1alpha in Her-2/neu overexpressors . Negative_regulation MAPK6 FHL1 23456229 2781805 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Negative_regulation MAPK6 FUT4 20506505 2307915 Results show that overexpression of *increases* the phosphorylation of ERK1/2 , p38 [MAPK] , and PI3K/Akt . Negative_regulation MAPK6 HBEGF 19048624 2023707 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked [MAPK] signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 MAPK , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Negative_regulation MAPK6 HBEGF 19919524 2166806 Western blot analysis showed *prevents* ethanol from altering [MAPK] phosphorylation . Negative_regulation MAPK6 IL1B 12388337 1031345 CO treatment inhibited induced ERK1/2 activation but did not *inhibit* JNK and p38 [MAPK] . Negative_regulation MAPK6 IL1B 16718462 1584891 A synthetic peptide , C3d , reported to bind NCAM , did not activate [MAPK] or Akt as reported in neurons but *inhibited* induced MAPK activity , thereby mimicking the effect of SU5402 . Negative_regulation MAPK6 IL1B 18669445 1973104 DPML significantly inhibited tumor necrosis factor alpha , , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 [mitogen activated protein kinase] activation in the lung . Negative_regulation MAPK6 IL1B 19214751 2071836 triggered the activation of p38 and ERK1/2 ( p44/42) MAP kinase (MAPK) signaling pathways , but WIN55,212-2 mainly *inhibited* p38 [MAPK] phosphorylation . Negative_regulation MAPK6 LBP 19010986 2029064 and sCD14 *inhibited* the nontypeable Haemophilus influenzae ( NTHi ) -dependent secretion of IL-8 and the activation of NF-kappaB and p38 [mitogen activated protein kinase] signalling pathways but they increased the internalisation of NTHi by airway epithelial cells . Negative_regulation MAPK6 MAP2K6 11237743 790252 The [MAPK] kinase ( ) *inhibitor* , PD98059 , blocked GSA stimulated MAPK activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Negative_regulation MAPK6 MAP2K6 11258898 795533 T ( 4 ) -induced nuclear complexing of p53 and MAPK was inhibited by PD 98059 ( PD ) and U0126 , two [MAPK] kinase ( ) *inhibitors* , and was absent in cells treated with MEK antisense oligonucleotide and in dominant negative Ras cells . Negative_regulation MAPK6 MAP2K6 11304531 826806 The activation of p38 [MAPK] by Galpha ( q ) and Gbetagamma was *blocked* by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Negative_regulation MAPK6 MAP2K6 11399487 824176 The role of MAPK activation on GPalpha , FSHbeta and LHbeta gene expression was determined by administration of [MAPK-kinase] ( ) *inhibitor* ( PD98059 ; Negative_regulation MAPK6 MAP2K6 11744690 915763 Furthermore , the activation of p38 [MAPK] caused by overexpressing active RasVHa could not be inhibited using dominant negative mutants of MyD88 , IRAK , or IRAK-2 , or TRAF6 , but could be *inhibited* by dominant negative MKK3 or . Negative_regulation MAPK6 MAP2K6 11787422 891874 Indeed the [MAPK] kinase ( = ) *inhibitor* PD98059 inhibits the activation of parasite MAPK , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Negative_regulation MAPK6 MAP2K6 12649265 1080043 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant or p38beta2 MAPK *inhibited* interleukin-1beta induced p38 [MAPK] activation , COX-2 gene expression , and PGE2 release . Negative_regulation MAPK6 MAP2K6 12738672 1119569 Blocking the *activation* of p44/42 [mitogen activated protein kinase (MAPK)] by the specific mitogen induced extracellular kinase ( ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAPK6 MAP2K6 15284289 1277955 In contrast , a [mitogen activated protein (MAP) kinase/extracellular] signal regulated kinase ( ERK ) kinase ( ) /ERK *inhibitor* , PD98059 , completely abrogated the effect of high glucose . Negative_regulation MAPK6 MAP2K6 19606165 2105692 Overexpression of , a kinase upstream of p38 MAPK , *increased* phosphorylation of p38 [MAPK] and attenuated t-BOOH induced ARPE-19 cell death by 16 % . Negative_regulation MAPK6 MAP2K6 19915797 2197777 We confirmed the interaction between phospho-p38 and MAP4 using immunoprecipitation and found that SB203580 , a [p38/MAPK] *inhibitor* , increases and ( Glu ) overexpression decreases hypoxic cell viability . Negative_regulation MAPK6 MAP2K6 21323644 2447837 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAPK6 MAP2K6 22920673 2710243 We next analysed the effects of inhibiting signalling downstream of Ras , by specific *inhibitors* of [p38MAPK] , PI3-K or , on reoviral killing examined by MTT assay . Negative_regulation MAPK6 MAP2K6 23174698 2736000 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . inhibitor , U0126 completely blocked PKA inhibition *induced* [MAPK] activation and GVBD . Negative_regulation MAPK6 MUC16 22977714 2674040 Rottlerin ( PKCd inhibitor ) inhibited PMA induced expression , and also *inhibited* the phosphorylation of activated p38 [MAPK] by PMA . Negative_regulation MAPK6 PECAM1 19096001 2036169 These findings reveal that [p38MAPK] phosphorylation and platelet activation by LDL are *suppressed* by two mechanisms : ( 1 ) short activation of , and ( 2 ) prolonged activation of SHP-1 and SHP-2 . Negative_regulation MAPK6 PLAU 11606583 888446 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 [MAPK] and *inhibited* cell associated expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation MAPK6 PLAU 23615713 2804738 In addition , avß6 integrin *induced* the phosphorylation of p38 [MAPK] and PI3 K/Akt , contributing to the up-regulation of uPA , as treatment with the specific inhibitor for p38 mitogen activated protein kinases (MAPK) ( SB203580 ) or phosphatidylinositol 3-kinase (PI3 K)/Akt ( LY294002 ) strikingly abrogated expression . Negative_regulation MAPK6 RGS16 11602604 888215 These data suggest that tyrosine phosphorylation regulates RGS16 function and that EGFR may potentially *inhibit* Galpha ( i ) -dependent [MAPK] activation in a feedback loop by enhancing activity through tyrosine phosphorylation . Negative_regulation MAPK6 S100B 19961838 2199388 Albumin activated ERK1/2 , p38 [MAPK] and JNK signaling pathways in astrocytes , and *induced* the production of interleukin (IL)-1beta , inducible nitric oxide (NO) synthase , the NO metabolite nitrite , and the chemokine CX3CL1 while reducing the level of . Negative_regulation MAPK6 SPHK1 22684547 2705926 increased the constitutive expression of extracellular signal regulated kinase1/2 ( ERK1/2 ) but *reduced* the constitutive expression of p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK6 TCN1 23018889 2720342 Furthermore , whereas Compound C ( an AMPK inhibitor ) , AMPK-DN ( AMPK-dominant negative ) mutant , and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA *inhibited* the 8-Cl-cAMP- and AICAR mediated phosphorylation of AMPK and p38 [MAPK] . Negative_regulation MAPK6 TNF 10657669 664229 When KC was instilled as a proinflammatory stimulus , neutrophil accumulation was significantly decreased by p38 [MAPK] *inhibition* independent of or LPS . Negative_regulation MAPK6 TNF 12297293 991249 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Negative_regulation MAPK6 TNF 14729457 1198466 Among other cellular responses , *induces* different forms of cell death and the activation of the p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK6 TNF 15015934 1251084 Stimulation of human skin fibroblasts or articular chondrocytes with IL-1 or in the presence of HC-gp39 *resulted* in a marked reduction of both p38 [mitogen activated protein kinase] and stress activated protein kinase/Jun N-terminal kinase phosphorylation , whereas nuclear translocation of nuclear factor kappaB proceeded unimpeded . Negative_regulation MAPK6 TNF 15519192 1328841 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial TNFalpha mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 [MAPK] activation . Negative_regulation MAPK6 TNF 15763380 1383459 Furthermore , pretreatment with oxymatrine significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet-to-dry weight ratio , decreases in serum level and *inhibition* of phosphorylated p38 [MAPK] . Negative_regulation MAPK6 TNF 15952594 1421647 Pretreatment of EGCG significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet to dry weight ratio , decreased of level in serum and *inhibition* of phosphorylation of p38 [MAPK] . Negative_regulation MAPK6 TNF 17189827 1680117 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Negative_regulation MAPK6 TNF 17214640 1681826 Roxithromycin significantly inhibited induced c-Jun N-terminal kinase activation ( JNP ) and marginally *inhibited* extracellular signal regulated kinase ( ERK ) 1/2 activation , but not p38 [mitogen activated protein kinase] activation . Negative_regulation MAPK6 TNF 17438131 1742716 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Negative_regulation MAPK6 TNF 19086324 2000278 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 [MAPK] and NF-kappaB activities , and then overexpression , thus alleviating the inflammatory reaction . Negative_regulation MAPK6 TNF 19118509 2004859 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and and *inhibited* the phosphorylation of Akt , PKCdelta and p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK6 TNF 19450605 2096922 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 [MAPK] and *inhibited* cardiac expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation MAPK6 TNF 21147093 2378305 LPS induced phosphorylation of I?Ba and p38 [MAPK] was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation MAPK6 TNF 23056531 2685410 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit a ( TNF-a production in cultured macrophages ) and in vitro [MAPK] p38a *inhibition* . Negative_regulation MAPK6 TNF 23066265 2685771 Doxycycline , nonsteroidal anti-inflammatory drugs ( NSAIDs ) , bisphosphonates , nitrous oxide ( NO ) synthase inhibitors , recombinant human interleukin-11 ( rhIL-11 ) , omega-3 fatty acid , mouse anti-human interleukin-6 receptor antibody ( MRA ) , [mitogen activated protein kinase (MAPK)] *inhibitors* , nuclear factor-kappa B (NF-kb) inhibitors , osteoprotegerin , and tumor necrosis factor antagonist ( ) are some of the therapeutic agents that have host modulation properties . Negative_regulation MAPK6 TNF 23518420 2777205 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and protein expression in the kidney , as well as *inhibiting* [p38MAPK] signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation MAPK6 TNF 24152910 2875266 It was found that thrombin down-regulates the HMGB1 mediated induction of both and IL-6 and *inhibits* the activation of both p38 [MAPK] and NF-?B in HUVECs pretreated with PC . Negative_regulation MAPK6 TNF 8665940 368991 Low concentrations ( 2 nM ) of okadaic acid , a serine/threonine phosphatase inhibitor , prevented induced *inhibition* of [MAPK] and restored insulin 's effect on MAPK activity , while orthovanadate ( a tyrosine phosphatase inhibitor ) , inhibitor 2 ( phosphatase-1 inhibitor ) and FK506 ( phosphatase-2B inhibitor ) were ineffective . Negative_regulation MAPK7 ANGPT1 24308939 2877798 The functional roles of DUSPs in *induced* regulation of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Negative_regulation MAPK7 ARSA 18563667 1952785 *inhibited* p38 [MAPK] but not ERK1/2 phosphorylation in washed platelets . Negative_regulation MAPK7 CCND1 19369047 2258051 We propose that breast cancer cell proliferation is inhibited by DHA through proteasome dependent degradation of ERalpha , reduced expression and *inhibition* of [MAPK] signaling . Negative_regulation MAPK7 CCND1 20113529 2213156 In contrast , focal adhesion/actin cytoskeleton , [MAPK] and NF B signaling appeared to characterize the target genes and their interacting proteins in *suppressed* PANC1 cells . Negative_regulation MAPK7 CCND1 24740537 2939081 Expression of or CDK4 *prevented* the dominant negative [Erk5-] or siErk5 mediated inhibition of DNA synthesis and mesangial cell proliferation induced by PDGF . Negative_regulation MAPK7 EPHB2 15810889 1392171 Thus , [MAPK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation MAPK7 EPHB2 15910808 1412156 The [MAPK/extracellular] signal regulated protein kinase ( ) kinase *inhibitor* , PD098059 ( 2'-amino-3'-methoxyflavone ) , significantly inhibited basal tone in a dose dependent manner . Negative_regulation MAPK7 EPHB2 16291589 1526014 TCCM treatment activated p38 [mitogen activated protein kinase (MAPK)] and Janus kinase (JNK) but *inhibited* . Negative_regulation MAPK7 EPHB2 16291589 1526042 Thus , our results suggested that tumor induced p38 [MAPK] activation and *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation MAPK7 EPHB2 17615677 1769085 We conclude that activation and p38 [MAPK] *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation MAPK7 EPHB2 18048804 1882906 No significant effects on HO-1 induction were observed with the pretreatment of [mitogen activated protein kinase] pathway *inhibitors* PD98059 ( ) , SB203580 ( p38MAPK ) and JNKi , and conventional and atypical PKC inhibitors . Negative_regulation MAPK7 EPHB2 18567920 1952844 CypA induced nuclear factor kappaB (NF-kappaB) activity for MMP-9 transcription were strongly blocked by extracellular signal regulated kinase ( ) , c-Jun amino terminal kinase (JNK) inhibitors ( U0126 and SP600125 , respectively ) , but not by p38 [mitogen activated protein kinase (MAPK)] *inhibitors* ( SB203580 ) . Negative_regulation MAPK7 EPHB2 19180563 2049272 Activated *suppressed* p38 [MAPK] activation and Fas/FasL protein expression . Negative_regulation MAPK7 EPHB2 19428337 2077019 Histological examination of lung tissues revealed that [MAPK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation MAPK7 EPHB2 20881039 2347123 Extracellular signal regulated receptor kinase ( ) and p38 [mitogen activated protein kinase] *inhibitors* ( U0126 and SB203580 ) were sufficient to block Nup hyperphosphorylation in EMCV infected or L-expressing cells . Negative_regulation MAPK7 EPHB2 21323644 2447839 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) signalling . Negative_regulation MAPK7 EPHB2 21663947 2459783 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation MAPK7 EPHB2 22129743 2515098 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 [mitogen activated protein kinase (MAPK)] and Akt phosphorylation , but in contrast , *inhibited* that of ( 1/2 ) . Negative_regulation MAPK7 EPHB2 22521802 2630867 Overexpression of the signaling protein Smad3 *enhanced* TGF-ß induced activation of ERK [MAPK] , whereas inhibition of Smad3 with a siRNA blocked MAPK phosphorylation in response to TGF-ß . Negative_regulation MAPK7 FAS 15669079 1382150 Concurrently , blockade drastically *activated* [MAPK] and promoted further a prominent accumulation of HIF-1alpha in Her-2/neu overexpressors . Negative_regulation MAPK7 FHL1 23456229 2781806 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Negative_regulation MAPK7 FUT4 20506505 2307916 Results show that overexpression of *increases* the phosphorylation of ERK1/2 , p38 [MAPK] , and PI3K/Akt . Negative_regulation MAPK7 HBEGF 19048624 2023708 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked MAPK signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 [MAPK] , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Negative_regulation MAPK7 HBEGF 19919524 2166807 Western blot analysis showed *prevents* ethanol from altering [MAPK] phosphorylation . Negative_regulation MAPK7 IL1B 12388337 1031347 CO treatment inhibited induced ERK1/2 activation but did not *inhibit* JNK and p38 [MAPK] . Negative_regulation MAPK7 IL1B 16718462 1584895 A synthetic peptide , C3d , reported to bind NCAM , did not activate [MAPK] or Akt as reported in neurons but *inhibited* induced MAPK activity , thereby mimicking the effect of SU5402 . Negative_regulation MAPK7 IL1B 18669445 1973106 DPML significantly inhibited tumor necrosis factor alpha , , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 [mitogen activated protein kinase] activation in the lung . Negative_regulation MAPK7 IL1B 19214751 2071839 triggered the activation of p38 and ERK1/2 ( p44/42) MAP kinase (MAPK) signaling pathways , but WIN55,212-2 mainly *inhibited* p38 [MAPK] phosphorylation . Negative_regulation MAPK7 LBP 19010986 2029065 and sCD14 *inhibited* the nontypeable Haemophilus influenzae ( NTHi ) -dependent secretion of IL-8 and the activation of NF-kappaB and p38 [mitogen activated protein kinase] signalling pathways but they increased the internalisation of NTHi by airway epithelial cells . Negative_regulation MAPK7 MAP2K6 11237743 790259 The [MAPK] kinase ( ) *inhibitor* , PD98059 , blocked GSA stimulated MAPK activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Negative_regulation MAPK7 MAP2K6 11258898 795540 T ( 4 ) -induced nuclear complexing of p53 and MAPK was inhibited by PD 98059 ( PD ) and U0126 , two [MAPK] kinase ( ) *inhibitors* , and was absent in cells treated with MEK antisense oligonucleotide and in dominant negative Ras cells . Negative_regulation MAPK7 MAP2K6 11304531 826809 The activation of p38 [MAPK] by Galpha ( q ) and Gbetagamma was *blocked* by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Negative_regulation MAPK7 MAP2K6 11399487 824183 The role of MAPK activation on GPalpha , FSHbeta and LHbeta gene expression was determined by administration of [MAPK-kinase] ( ) *inhibitor* ( PD98059 ; Negative_regulation MAPK7 MAP2K6 11744690 915765 Furthermore , the activation of p38 [MAPK] caused by overexpressing active RasVHa could not be inhibited using dominant negative mutants of MyD88 , IRAK , or IRAK-2 , or TRAF6 , but could be *inhibited* by dominant negative MKK3 or . Negative_regulation MAPK7 MAP2K6 11787422 891881 Indeed the [MAPK] kinase ( = ) *inhibitor* PD98059 inhibits the activation of parasite MAPK , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Negative_regulation MAPK7 MAP2K6 12649265 1080044 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant or p38beta2 MAPK *inhibited* interleukin-1beta induced p38 [MAPK] activation , COX-2 gene expression , and PGE2 release . Negative_regulation MAPK7 MAP2K6 12738672 1119576 Blocking the *activation* of p44/42 [mitogen activated protein kinase (MAPK)] by the specific mitogen induced extracellular kinase ( ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAPK7 MAP2K6 15284289 1277962 In contrast , a [mitogen activated protein (MAP) kinase/extracellular] signal regulated kinase ( ERK ) kinase ( ) /ERK *inhibitor* , PD98059 , completely abrogated the effect of high glucose . Negative_regulation MAPK7 MAP2K6 19606165 2105693 Overexpression of , a kinase upstream of p38 MAPK , *increased* phosphorylation of p38 [MAPK] and attenuated t-BOOH induced ARPE-19 cell death by 16 % . Negative_regulation MAPK7 MAP2K6 19915797 2197778 We confirmed the interaction between phospho-p38 and MAP4 using immunoprecipitation and found that SB203580 , a [p38/MAPK] *inhibitor* , increases and ( Glu ) overexpression decreases hypoxic cell viability . Negative_regulation MAPK7 MAP2K6 21323644 2447845 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAPK7 MAP2K6 22920673 2710252 We next analysed the effects of inhibiting signalling downstream of Ras , by specific *inhibitors* of [p38MAPK] , PI3-K or , on reoviral killing examined by MTT assay . Negative_regulation MAPK7 MAP2K6 23174698 2736007 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . inhibitor , U0126 completely blocked PKA inhibition *induced* [MAPK] activation and GVBD . Negative_regulation MAPK7 MUC16 22977714 2674041 Rottlerin ( PKCd inhibitor ) inhibited PMA induced expression , and also *inhibited* the phosphorylation of activated p38 [MAPK] by PMA . Negative_regulation MAPK7 PECAM1 19096001 2036175 These findings reveal that [p38MAPK] phosphorylation and platelet activation by LDL are *suppressed* by two mechanisms : ( 1 ) short activation of , and ( 2 ) prolonged activation of SHP-1 and SHP-2 . Negative_regulation MAPK7 PLAU 11606583 888447 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 [MAPK] and *inhibited* cell associated expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation MAPK7 PLAU 23615713 2804739 In addition , avß6 integrin *induced* the phosphorylation of p38 [MAPK] and PI3 K/Akt , contributing to the up-regulation of uPA , as treatment with the specific inhibitor for p38 mitogen activated protein kinases (MAPK) ( SB203580 ) or phosphatidylinositol 3-kinase (PI3 K)/Akt ( LY294002 ) strikingly abrogated expression . Negative_regulation MAPK7 RGS16 11602604 888217 These data suggest that tyrosine phosphorylation regulates function and that EGFR may potentially *inhibit* Galpha ( i ) -dependent [MAPK] activation in a feedback loop by enhancing RGS16 activity through tyrosine phosphorylation . Negative_regulation MAPK7 S100B 19961838 2199389 Albumin activated ERK1/2 , p38 [MAPK] and JNK signaling pathways in astrocytes , and *induced* the production of interleukin (IL)-1beta , inducible nitric oxide (NO) synthase , the NO metabolite nitrite , and the chemokine CX3CL1 while reducing the level of . Negative_regulation MAPK7 SPHK1 22684547 2705927 increased the constitutive expression of extracellular signal regulated kinase1/2 ( ERK1/2 ) but *reduced* the constitutive expression of p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK7 TCN1 23018889 2720350 Furthermore , whereas Compound C ( an AMPK inhibitor ) , AMPK-DN ( AMPK-dominant negative ) mutant , and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA *inhibited* the 8-Cl-cAMP- and AICAR mediated phosphorylation of AMPK and p38 [MAPK] . Negative_regulation MAPK7 TNF 10657669 664231 When KC was instilled as a proinflammatory stimulus , neutrophil accumulation was significantly decreased by p38 [MAPK] *inhibition* independent of or LPS . Negative_regulation MAPK7 TNF 12297293 991250 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Negative_regulation MAPK7 TNF 14729457 1198467 Among other cellular responses , *induces* different forms of cell death and the activation of the p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK7 TNF 15015934 1251086 Stimulation of human skin fibroblasts or articular chondrocytes with IL-1 or in the presence of HC-gp39 *resulted* in a marked reduction of both p38 [mitogen activated protein kinase] and stress activated protein kinase/Jun N-terminal kinase phosphorylation , whereas nuclear translocation of nuclear factor kappaB proceeded unimpeded . Negative_regulation MAPK7 TNF 15519192 1328842 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as TNFalpha production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 [MAPK] activation . Negative_regulation MAPK7 TNF 15763380 1383460 Furthermore , pretreatment with oxymatrine significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet-to-dry weight ratio , decreases in serum level and *inhibition* of phosphorylated p38 [MAPK] . Negative_regulation MAPK7 TNF 15952594 1421648 Pretreatment of EGCG significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet to dry weight ratio , decreased of level in serum and *inhibition* of phosphorylation of p38 [MAPK] . Negative_regulation MAPK7 TNF 17189827 1680119 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Negative_regulation MAPK7 TNF 17214640 1681828 Roxithromycin significantly inhibited induced c-Jun N-terminal kinase activation ( JNP ) and marginally *inhibited* extracellular signal regulated kinase ( ERK ) 1/2 activation , but not p38 [mitogen activated protein kinase] activation . Negative_regulation MAPK7 TNF 17438131 1742717 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Negative_regulation MAPK7 TNF 19086324 2000279 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 [MAPK] and NF-kappaB activities , and then overexpression , thus alleviating the inflammatory reaction . Negative_regulation MAPK7 TNF 19118509 2004862 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and and *inhibited* the phosphorylation of Akt , PKCdelta and p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK7 TNF 19450605 2096923 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 [MAPK] and *inhibited* cardiac expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation MAPK7 TNF 21147093 2378308 LPS induced phosphorylation of I?Ba and p38 [MAPK] was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation MAPK7 TNF 23056531 2685412 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit a ( TNF-a production in cultured macrophages ) and in vitro [MAPK] p38a *inhibition* . Negative_regulation MAPK7 TNF 23066265 2685772 Doxycycline , nonsteroidal anti-inflammatory drugs ( NSAIDs ) , bisphosphonates , nitrous oxide ( NO ) synthase inhibitors , recombinant human interleukin-11 ( rhIL-11 ) , omega-3 fatty acid , mouse anti-human interleukin-6 receptor antibody ( MRA ) , [mitogen activated protein kinase (MAPK)] *inhibitors* , nuclear factor-kappa B (NF-kb) inhibitors , osteoprotegerin , and tumor necrosis factor antagonist ( ) are some of the therapeutic agents that have host modulation properties . Negative_regulation MAPK7 TNF 23518420 2777206 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and protein expression in the kidney , as well as *inhibiting* [p38MAPK] signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation MAPK7 TNF 24152910 2875269 It was found that thrombin down-regulates the HMGB1 mediated induction of both and IL-6 and *inhibits* the activation of both p38 [MAPK] and NF-?B in HUVECs pretreated with PC . Negative_regulation MAPK7 TNF 8665940 368992 Low concentrations ( 2 nM ) of okadaic acid , a serine/threonine phosphatase inhibitor , prevented *induced* inhibition of [MAPK] and restored insulin 's effect on MAPK activity , while orthovanadate ( a tyrosine phosphatase inhibitor ) , inhibitor 2 ( phosphatase-1 inhibitor ) and FK506 ( phosphatase-2B inhibitor ) were ineffective . Negative_regulation MAPK8 ANGPT1 24308939 2877799 The functional roles of DUSPs in *induced* regulation of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Negative_regulation MAPK8 ARSA 18563667 1952786 *inhibited* p38 [MAPK] but not ERK1/2 phosphorylation in washed platelets . Negative_regulation MAPK8 CCND1 19369047 2258052 We propose that breast cancer cell proliferation is inhibited by DHA through proteasome dependent degradation of ERalpha , reduced expression and *inhibition* of [MAPK] signaling . Negative_regulation MAPK8 CCND1 20113529 2213157 In contrast , focal adhesion/actin cytoskeleton , [MAPK] and NF B signaling appeared to characterize the target genes and their interacting proteins in *suppressed* PANC1 cells . Negative_regulation MAPK8 EPHB2 15810889 1392172 Thus , [MAPK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation MAPK8 EPHB2 15910808 1412157 The [MAPK/extracellular] signal regulated protein kinase ( ) kinase *inhibitor* , PD098059 ( 2'-amino-3'-methoxyflavone ) , significantly inhibited basal tone in a dose dependent manner . Negative_regulation MAPK8 EPHB2 16291589 1526015 TCCM treatment activated p38 [mitogen activated protein kinase (MAPK)] and Janus kinase (JNK) but *inhibited* . Negative_regulation MAPK8 EPHB2 16291589 1526043 Thus , our results suggested that tumor induced p38 [MAPK] activation and *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation MAPK8 EPHB2 17615677 1769087 We conclude that activation and p38 [MAPK] *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation MAPK8 EPHB2 17637226 1770765 it also promoted the activation of during the early phase of reperfusion but *inhibited* the activation of [p-JNK1/2] and p-p38 following the 30-minute , 1-hour and 3-hour intervals of reperfusion . Negative_regulation MAPK8 EPHB2 18048804 1882907 No significant effects on HO-1 induction were observed with the pretreatment of [mitogen activated protein kinase] pathway *inhibitors* PD98059 ( ) , SB203580 ( p38MAPK ) and JNKi , and conventional and atypical PKC inhibitors . Negative_regulation MAPK8 EPHB2 18567920 1952845 CypA induced nuclear factor kappaB (NF-kappaB) activity for MMP-9 transcription were strongly blocked by extracellular signal regulated kinase ( ) , c-Jun amino terminal kinase (JNK) inhibitors ( U0126 and SP600125 , respectively ) , but not by p38 [mitogen activated protein kinase (MAPK)] *inhibitors* ( SB203580 ) . Negative_regulation MAPK8 EPHB2 19180563 2049273 Activated *suppressed* p38 [MAPK] activation and Fas/FasL protein expression . Negative_regulation MAPK8 EPHB2 19428337 2077020 Histological examination of lung tissues revealed that [MAPK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation MAPK8 EPHB2 20881039 2347124 Extracellular signal regulated receptor kinase ( ) and p38 [mitogen activated protein kinase] *inhibitors* ( U0126 and SB203580 ) were sufficient to block Nup hyperphosphorylation in EMCV infected or L-expressing cells . Negative_regulation MAPK8 EPHB2 21323644 2447847 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) signalling . Negative_regulation MAPK8 EPHB2 21663947 2459786 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation MAPK8 EPHB2 22129743 2515099 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 [mitogen activated protein kinase (MAPK)] and Akt phosphorylation , but in contrast , *inhibited* that of ( 1/2 ) . Negative_regulation MAPK8 EPHB2 22521802 2630869 Overexpression of the signaling protein Smad3 *enhanced* TGF-ß induced activation of ERK [MAPK] , whereas inhibition of Smad3 with a siRNA blocked MAPK phosphorylation in response to TGF-ß . Negative_regulation MAPK8 FAS 15669079 1382151 Concurrently , blockade drastically *activated* [MAPK] and promoted further a prominent accumulation of HIF-1alpha in Her-2/neu overexpressors . Negative_regulation MAPK8 FHL1 23456229 2781807 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Negative_regulation MAPK8 FUT4 20506505 2307917 Results show that overexpression of *increases* the phosphorylation of ERK1/2 , p38 [MAPK] , and PI3K/Akt . Negative_regulation MAPK8 HBEGF 19048624 2023709 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked [MAPK] signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 MAPK , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Negative_regulation MAPK8 HBEGF 19919524 2166808 Western blot analysis showed *prevents* ethanol from altering [MAPK] phosphorylation . Negative_regulation MAPK8 IL1B 12388337 1031349 CO treatment inhibited induced ERK1/2 activation but did not *inhibit* JNK and p38 [MAPK] . Negative_regulation MAPK8 IL1B 16718462 1584899 A synthetic peptide , C3d , reported to bind NCAM , did not activate [MAPK] or Akt as reported in neurons but *inhibited* induced MAPK activity , thereby mimicking the effect of SU5402 . Negative_regulation MAPK8 IL1B 18669445 1973108 DPML significantly inhibited tumor necrosis factor alpha , , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 [mitogen activated protein kinase] activation in the lung . Negative_regulation MAPK8 IL1B 19214751 2071842 triggered the activation of p38 and ERK1/2 ( p44/42) MAP kinase (MAPK) signaling pathways , but WIN55,212-2 mainly *inhibited* p38 [MAPK] phosphorylation . Negative_regulation MAPK8 LBP 19010986 2029066 and sCD14 *inhibited* the nontypeable Haemophilus influenzae ( NTHi ) -dependent secretion of IL-8 and the activation of NF-kappaB and p38 [mitogen activated protein kinase] signalling pathways but they increased the internalisation of NTHi by airway epithelial cells . Negative_regulation MAPK8 MAP2K6 11237743 790266 The [MAPK] kinase ( ) *inhibitor* , PD98059 , blocked GSA stimulated MAPK activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Negative_regulation MAPK8 MAP2K6 11258898 795547 T ( 4 ) -induced nuclear complexing of p53 and MAPK was inhibited by PD 98059 ( PD ) and U0126 , two [MAPK] kinase ( ) *inhibitors* , and was absent in cells treated with MEK antisense oligonucleotide and in dominant negative Ras cells . Negative_regulation MAPK8 MAP2K6 11304531 826812 The activation of p38 [MAPK] by Galpha ( q ) and Gbetagamma was *blocked* by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Negative_regulation MAPK8 MAP2K6 11399487 824190 The role of MAPK activation on GPalpha , FSHbeta and LHbeta gene expression was determined by administration of [MAPK-kinase] ( ) *inhibitor* ( PD98059 ; Negative_regulation MAPK8 MAP2K6 11744690 915767 Furthermore , the activation of p38 [MAPK] caused by overexpressing active RasVHa could not be inhibited using dominant negative mutants of MyD88 , IRAK , or IRAK-2 , or TRAF6 , but could be *inhibited* by dominant negative MKK3 or . Negative_regulation MAPK8 MAP2K6 11787422 891888 Indeed the [MAPK] kinase ( = ) *inhibitor* PD98059 inhibits the activation of parasite MAPK , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Negative_regulation MAPK8 MAP2K6 12649265 1080045 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant or p38beta2 MAPK *inhibited* interleukin-1beta induced p38 [MAPK] activation , COX-2 gene expression , and PGE2 release . Negative_regulation MAPK8 MAP2K6 12738672 1119583 Blocking the *activation* of p44/42 [mitogen activated protein kinase (MAPK)] by the specific mitogen induced extracellular kinase ( ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAPK8 MAP2K6 15284289 1277969 In contrast , a [mitogen activated protein (MAP) kinase/extracellular] signal regulated kinase ( ERK ) kinase ( ) /ERK *inhibitor* , PD98059 , completely abrogated the effect of high glucose . Negative_regulation MAPK8 MAP2K6 19606165 2105694 Overexpression of , a kinase upstream of p38 MAPK , *increased* phosphorylation of p38 [MAPK] and attenuated t-BOOH induced ARPE-19 cell death by 16 % . Negative_regulation MAPK8 MAP2K6 19915797 2197779 We confirmed the interaction between phospho-p38 and MAP4 using immunoprecipitation and found that SB203580 , a [p38/MAPK] *inhibitor* , increases and ( Glu ) overexpression decreases hypoxic cell viability . Negative_regulation MAPK8 MAP2K6 21323644 2447853 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAPK8 MAP2K6 22920673 2710261 We next analysed the effects of inhibiting signalling downstream of Ras , by specific *inhibitors* of [p38MAPK] , PI3-K or , on reoviral killing examined by MTT assay . Negative_regulation MAPK8 MAP2K6 23174698 2736014 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . inhibitor , U0126 completely blocked PKA inhibition *induced* [MAPK] activation and GVBD . Negative_regulation MAPK8 MAP2K6 8637721 362413 The over-expression of MUK or in NIH3T3 or COS1 cells *results* in the activation of [JNK1] and the accumulation of a hyper phosphorylated form of c-Jun . Negative_regulation MAPK8 MUC16 22977714 2674042 Rottlerin ( PKCd inhibitor ) inhibited PMA induced expression , and also *inhibited* the phosphorylation of activated p38 [MAPK] by PMA . Negative_regulation MAPK8 PECAM1 19096001 2036181 These findings reveal that [p38MAPK] phosphorylation and platelet activation by LDL are *suppressed* by two mechanisms : ( 1 ) short activation of , and ( 2 ) prolonged activation of SHP-1 and SHP-2 . Negative_regulation MAPK8 PLAU 11606583 888448 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 [MAPK] and *inhibited* cell associated expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation MAPK8 PLAU 23615713 2804740 In addition , avß6 integrin *induced* the phosphorylation of p38 [MAPK] and PI3 K/Akt , contributing to the up-regulation of uPA , as treatment with the specific inhibitor for p38 mitogen activated protein kinases (MAPK) ( SB203580 ) or phosphatidylinositol 3-kinase (PI3 K)/Akt ( LY294002 ) strikingly abrogated expression . Negative_regulation MAPK8 RGS16 11602604 888219 These data suggest that tyrosine phosphorylation regulates RGS16 function and that EGFR may potentially *inhibit* Galpha ( i ) -dependent [MAPK] activation in a feedback loop by enhancing activity through tyrosine phosphorylation . Negative_regulation MAPK8 S100B 19961838 2199390 Albumin activated ERK1/2 , p38 [MAPK] and JNK signaling pathways in astrocytes , and *induced* the production of interleukin (IL)-1beta , inducible nitric oxide (NO) synthase , the NO metabolite nitrite , and the chemokine CX3CL1 while reducing the level of . Negative_regulation MAPK8 SPHK1 22684547 2705928 increased the constitutive expression of extracellular signal regulated kinase1/2 ( ERK1/2 ) but *reduced* the constitutive expression of p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK8 TCN1 23018889 2720358 Furthermore , whereas Compound C ( an AMPK inhibitor ) , AMPK-DN ( AMPK-dominant negative ) mutant , and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA *inhibited* the 8-Cl-cAMP- and AICAR mediated phosphorylation of AMPK and p38 [MAPK] . Negative_regulation MAPK8 TNF 10657669 664233 When KC was instilled as a proinflammatory stimulus , neutrophil accumulation was significantly decreased by p38 [MAPK] *inhibition* independent of or LPS . Negative_regulation MAPK8 TNF 12297293 991251 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Negative_regulation MAPK8 TNF 14729457 1198468 Among other cellular responses , *induces* different forms of cell death and the activation of the p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK8 TNF 15015934 1251088 Stimulation of human skin fibroblasts or articular chondrocytes with IL-1 or in the presence of HC-gp39 *resulted* in a marked reduction of both p38 [mitogen activated protein kinase] and stress activated protein kinase/Jun N-terminal kinase phosphorylation , whereas nuclear translocation of nuclear factor kappaB proceeded unimpeded . Negative_regulation MAPK8 TNF 15519192 1328843 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial TNFalpha mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 [MAPK] activation . Negative_regulation MAPK8 TNF 15763380 1383461 Furthermore , pretreatment with oxymatrine significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet-to-dry weight ratio , decreases in serum level and *inhibition* of phosphorylated p38 [MAPK] . Negative_regulation MAPK8 TNF 15952594 1421649 Pretreatment of EGCG significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet to dry weight ratio , decreased of level in serum and *inhibition* of phosphorylation of p38 [MAPK] . Negative_regulation MAPK8 TNF 17189827 1680121 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Negative_regulation MAPK8 TNF 17214640 1681830 Roxithromycin significantly inhibited induced c-Jun N-terminal kinase activation ( JNP ) and marginally *inhibited* extracellular signal regulated kinase ( ERK ) 1/2 activation , but not p38 [mitogen activated protein kinase] activation . Negative_regulation MAPK8 TNF 17438131 1742718 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Negative_regulation MAPK8 TNF 19086324 2000280 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 [MAPK] and NF-kappaB activities , and then overexpression , thus alleviating the inflammatory reaction . Negative_regulation MAPK8 TNF 19118509 2004865 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and and *inhibited* the phosphorylation of Akt , PKCdelta and p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK8 TNF 19450605 2096924 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 [MAPK] and *inhibited* cardiac expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation MAPK8 TNF 21147093 2378311 LPS induced phosphorylation of I?Ba and p38 [MAPK] was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation MAPK8 TNF 23056531 2685414 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit a ( TNF-a production in cultured macrophages ) and in vitro [MAPK] p38a *inhibition* . Negative_regulation MAPK8 TNF 23066265 2685773 Doxycycline , nonsteroidal anti-inflammatory drugs ( NSAIDs ) , bisphosphonates , nitrous oxide ( NO ) synthase inhibitors , recombinant human interleukin-11 ( rhIL-11 ) , omega-3 fatty acid , mouse anti-human interleukin-6 receptor antibody ( MRA ) , [mitogen activated protein kinase (MAPK)] *inhibitors* , nuclear factor-kappa B (NF-kb) inhibitors , osteoprotegerin , and tumor necrosis factor antagonist ( ) are some of the therapeutic agents that have host modulation properties . Negative_regulation MAPK8 TNF 23518420 2777207 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and protein expression in the kidney , as well as *inhibiting* [p38MAPK] signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation MAPK8 TNF 24152910 2875272 It was found that thrombin down-regulates the HMGB1 mediated induction of both and IL-6 and *inhibits* the activation of both p38 [MAPK] and NF-?B in HUVECs pretreated with PC . Negative_regulation MAPK8 TNF 8665940 368993 Low concentrations ( 2 nM ) of okadaic acid , a serine/threonine phosphatase inhibitor , prevented induced *inhibition* of [MAPK] and restored insulin 's effect on MAPK activity , while orthovanadate ( a tyrosine phosphatase inhibitor ) , inhibitor 2 ( phosphatase-1 inhibitor ) and FK506 ( phosphatase-2B inhibitor ) were ineffective . Negative_regulation MAPK8IP1 IL1B 14514632 1146948 Studies in beta-cell lines indicated that *reduced* expression of [islet brain (IB)-1/JNK] interacting protein (JIP)-1 , a JNK scaffold protein with antiapoptotic action . Negative_regulation MAPK8IP1 IL1B 14514632 1146950 A similar increase in TNF-alpha + IFN-gamma induced apoptosis was produced by adenoviral expression of antisense IB1/JIP-1 and was not further enhanced by addition of IL-1beta , indicating that *mediated* suppression of [IB1/JIP-1] in beta-cells increases their susceptibility to cytokine induced apoptosis . Negative_regulation MAPK9 ANGPT1 24308939 2877800 The functional roles of DUSPs in *induced* regulation of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Negative_regulation MAPK9 ARSA 18563667 1952787 *inhibited* p38 [MAPK] but not ERK1/2 phosphorylation in washed platelets . Negative_regulation MAPK9 CCND1 19369047 2258053 We propose that breast cancer cell proliferation is inhibited by DHA through proteasome dependent degradation of ERalpha , reduced expression and *inhibition* of [MAPK] signaling . Negative_regulation MAPK9 CCND1 20113529 2213158 In contrast , focal adhesion/actin cytoskeleton , [MAPK] and NF B signaling appeared to characterize the target genes and their interacting proteins in *suppressed* PANC1 cells . Negative_regulation MAPK9 EPHB2 15810889 1392173 Thus , [MAPK] *inhibition* may represent a therapeutic strategy for preventing monocytic precursor diversion away from DC differentiation when monocytes enter injured tissues in which iC3b is generated , such as UV-exposed skin . Negative_regulation MAPK9 EPHB2 15910808 1412158 The [MAPK/extracellular] signal regulated protein kinase ( ) kinase *inhibitor* , PD098059 ( 2'-amino-3'-methoxyflavone ) , significantly inhibited basal tone in a dose dependent manner . Negative_regulation MAPK9 EPHB2 16291589 1526016 TCCM treatment activated p38 [mitogen activated protein kinase (MAPK)] and Janus kinase (JNK) but *inhibited* . Negative_regulation MAPK9 EPHB2 16291589 1526044 Thus , our results suggested that tumor induced p38 [MAPK] activation and *inhibition* in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer . Negative_regulation MAPK9 EPHB2 17615677 1769089 We conclude that activation and p38 [MAPK] *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation MAPK9 EPHB2 18048804 1882908 No significant effects on HO-1 induction were observed with the pretreatment of [mitogen activated protein kinase] pathway *inhibitors* PD98059 ( ) , SB203580 ( p38MAPK ) and JNKi , and conventional and atypical PKC inhibitors . Negative_regulation MAPK9 EPHB2 18567920 1952846 CypA induced nuclear factor kappaB (NF-kappaB) activity for MMP-9 transcription were strongly blocked by extracellular signal regulated kinase ( ) , c-Jun amino terminal kinase (JNK) inhibitors ( U0126 and SP600125 , respectively ) , but not by p38 [mitogen activated protein kinase (MAPK)] *inhibitors* ( SB203580 ) . Negative_regulation MAPK9 EPHB2 19180563 2049274 Activated *suppressed* p38 [MAPK] activation and Fas/FasL protein expression . Negative_regulation MAPK9 EPHB2 19428337 2077021 Histological examination of lung tissues revealed that [MAPK] *inhibition* using U0126 efficiently attenuated LPS induced pulmonary inflammatory responses . Negative_regulation MAPK9 EPHB2 20881039 2347125 Extracellular signal regulated receptor kinase ( ) and p38 [mitogen activated protein kinase] *inhibitors* ( U0126 and SB203580 ) were sufficient to block Nup hyperphosphorylation in EMCV infected or L-expressing cells . Negative_regulation MAPK9 EPHB2 21323644 2447855 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of MEK ( MAPK/ERK kinase ) signalling . Negative_regulation MAPK9 EPHB2 21663947 2459789 We found that the hSef expression was positively regulated by FGF2 induced signaling and inversely , hSef expression efficiently *inhibited* the activity of FGF2 induced [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Negative_regulation MAPK9 EPHB2 22129743 2515100 Upon examination of signaling pathways involved in apoptosis process , we found that Pb induced p38 [mitogen activated protein kinase (MAPK)] and Akt phosphorylation , but in contrast , *inhibited* that of ( 1/2 ) . Negative_regulation MAPK9 EPHB2 22521802 2630871 Overexpression of the signaling protein Smad3 *enhanced* TGF-ß induced activation of ERK [MAPK] , whereas inhibition of Smad3 with a siRNA blocked MAPK phosphorylation in response to TGF-ß . Negative_regulation MAPK9 FAS 15669079 1382152 Concurrently , blockade drastically *activated* [MAPK] and promoted further a prominent accumulation of HIF-1alpha in Her-2/neu overexpressors . Negative_regulation MAPK9 FHL1 23456229 2781808 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Negative_regulation MAPK9 FUT4 20506505 2307918 Results show that overexpression of *increases* the phosphorylation of ERK1/2 , p38 [MAPK] , and PI3K/Akt . Negative_regulation MAPK9 HBEGF 19048624 2023710 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked MAPK signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 [MAPK] , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Negative_regulation MAPK9 HBEGF 19919524 2166809 Western blot analysis showed *prevents* ethanol from altering [MAPK] phosphorylation . Negative_regulation MAPK9 IL1B 12388337 1031351 CO treatment inhibited induced ERK1/2 activation but did not *inhibit* JNK and p38 [MAPK] . Negative_regulation MAPK9 IL1B 16718462 1584903 A synthetic peptide , C3d , reported to bind NCAM , did not activate [MAPK] or Akt as reported in neurons but *inhibited* induced MAPK activity , thereby mimicking the effect of SU5402 . Negative_regulation MAPK9 IL1B 18669445 1973110 DPML significantly inhibited tumor necrosis factor alpha , , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* NFkappaB and p38 [mitogen activated protein kinase] activation in the lung . Negative_regulation MAPK9 IL1B 19214751 2071845 triggered the activation of p38 and ERK1/2 ( p44/42) MAP kinase (MAPK) signaling pathways , but WIN55,212-2 mainly *inhibited* p38 [MAPK] phosphorylation . Negative_regulation MAPK9 LBP 19010986 2029067 and sCD14 *inhibited* the nontypeable Haemophilus influenzae ( NTHi ) -dependent secretion of IL-8 and the activation of NF-kappaB and p38 [mitogen activated protein kinase] signalling pathways but they increased the internalisation of NTHi by airway epithelial cells . Negative_regulation MAPK9 MAP2K6 11237743 790273 The [MAPK] kinase ( ) *inhibitor* , PD98059 , blocked GSA stimulated MAPK activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Negative_regulation MAPK9 MAP2K6 11258898 795554 T ( 4 ) -induced nuclear complexing of p53 and MAPK was inhibited by PD 98059 ( PD ) and U0126 , two [MAPK] kinase ( ) *inhibitors* , and was absent in cells treated with MEK antisense oligonucleotide and in dominant negative Ras cells . Negative_regulation MAPK9 MAP2K6 11304531 826815 The activation of p38 [MAPK] by Galpha ( q ) and Gbetagamma was *blocked* by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Negative_regulation MAPK9 MAP2K6 11399487 824197 The role of MAPK activation on GPalpha , FSHbeta and LHbeta gene expression was determined by administration of [MAPK-kinase] ( ) *inhibitor* ( PD98059 ; Negative_regulation MAPK9 MAP2K6 11744690 915769 Furthermore , the activation of p38 [MAPK] caused by overexpressing active RasVHa could not be inhibited using dominant negative mutants of MyD88 , IRAK , or IRAK-2 , or TRAF6 , but could be *inhibited* by dominant negative MKK3 or . Negative_regulation MAPK9 MAP2K6 11787422 891895 Indeed the [MAPK] kinase ( = ) *inhibitor* PD98059 inhibits the activation of parasite MAPK , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Negative_regulation MAPK9 MAP2K6 12649265 1080046 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant or p38beta2 MAPK *inhibited* interleukin-1beta induced p38 [MAPK] activation , COX-2 gene expression , and PGE2 release . Negative_regulation MAPK9 MAP2K6 12738672 1119590 Blocking the *activation* of p44/42 [mitogen activated protein kinase (MAPK)] by the specific mitogen induced extracellular kinase ( ) inhibitor , U0126 , impaired modestly the ability of FVIIa to promote cell survival . Negative_regulation MAPK9 MAP2K6 15284289 1277976 In contrast , a [mitogen activated protein (MAP) kinase/extracellular] signal regulated kinase ( ERK ) kinase ( ) /ERK *inhibitor* , PD98059 , completely abrogated the effect of high glucose . Negative_regulation MAPK9 MAP2K6 19606165 2105695 Overexpression of , a kinase upstream of p38 MAPK , *increased* phosphorylation of p38 [MAPK] and attenuated t-BOOH induced ARPE-19 cell death by 16 % . Negative_regulation MAPK9 MAP2K6 19915797 2197780 We confirmed the interaction between phospho-p38 and MAP4 using immunoprecipitation and found that SB203580 , a [p38/MAPK] *inhibitor* , increases and ( Glu ) overexpression decreases hypoxic cell viability . Negative_regulation MAPK9 MAP2K6 21323644 2447861 NF-?B activation by palmitate was unaffected by pharmacological inhibition of p38 [MAPK] or JNK , but was *suppressed* significantly by inhibition of ( MAPK/ERK kinase ) /ERK signalling . Negative_regulation MAPK9 MAP2K6 22920673 2710270 We next analysed the effects of inhibiting signalling downstream of Ras , by specific *inhibitors* of [p38MAPK] , PI3-K or , on reoviral killing examined by MTT assay . Negative_regulation MAPK9 MAP2K6 23174698 2736021 Though total protein content did not show significant variation , H89 stimulation was able to stimulate phosphorylation of ERK1/2 from 5h onwards and the strongest response was observed between 10 and 18 h . inhibitor , U0126 completely blocked PKA inhibition *induced* [MAPK] activation and GVBD . Negative_regulation MAPK9 MUC16 22977714 2674043 Rottlerin ( PKCd inhibitor ) inhibited PMA induced expression , and also *inhibited* the phosphorylation of activated p38 [MAPK] by PMA . Negative_regulation MAPK9 PECAM1 19096001 2036187 These findings reveal that [p38MAPK] phosphorylation and platelet activation by LDL are *suppressed* by two mechanisms : ( 1 ) short activation of , and ( 2 ) prolonged activation of SHP-1 and SHP-2 . Negative_regulation MAPK9 PLAU 11606583 888449 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 [MAPK] and *inhibited* cell associated expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation MAPK9 PLAU 23615713 2804741 In addition , avß6 integrin *induced* the phosphorylation of p38 [MAPK] and PI3 K/Akt , contributing to the up-regulation of uPA , as treatment with the specific inhibitor for p38 mitogen activated protein kinases (MAPK) ( SB203580 ) or phosphatidylinositol 3-kinase (PI3 K)/Akt ( LY294002 ) strikingly abrogated expression . Negative_regulation MAPK9 RGS16 11602604 888221 These data suggest that tyrosine phosphorylation regulates RGS16 function and that EGFR may potentially *inhibit* Galpha ( i ) -dependent [MAPK] activation in a feedback loop by enhancing activity through tyrosine phosphorylation . Negative_regulation MAPK9 S100B 19961838 2199391 Albumin activated ERK1/2 , p38 [MAPK] and JNK signaling pathways in astrocytes , and *induced* the production of interleukin (IL)-1beta , inducible nitric oxide (NO) synthase , the NO metabolite nitrite , and the chemokine CX3CL1 while reducing the level of . Negative_regulation MAPK9 SPHK1 22684547 2705929 increased the constitutive expression of extracellular signal regulated kinase1/2 ( ERK1/2 ) but *reduced* the constitutive expression of p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK9 TCN1 23018889 2720366 Furthermore , whereas Compound C ( an AMPK inhibitor ) , AMPK-DN ( AMPK-dominant negative ) mutant , and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA *inhibited* the 8-Cl-cAMP- and AICAR mediated phosphorylation of AMPK and p38 [MAPK] . Negative_regulation MAPK9 TNF 10657669 664235 When KC was instilled as a proinflammatory stimulus , neutrophil accumulation was significantly decreased by p38 [MAPK] *inhibition* independent of or LPS . Negative_regulation MAPK9 TNF 12297293 991252 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Negative_regulation MAPK9 TNF 14729457 1198469 Among other cellular responses , *induces* different forms of cell death and the activation of the p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK9 TNF 15015934 1251090 Stimulation of human skin fibroblasts or articular chondrocytes with IL-1 or in the presence of HC-gp39 *resulted* in a marked reduction of both p38 [mitogen activated protein kinase] and stress activated protein kinase/Jun N-terminal kinase phosphorylation , whereas nuclear translocation of nuclear factor kappaB proceeded unimpeded . Negative_regulation MAPK9 TNF 15519192 1328844 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as TNFalpha production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 [MAPK] activation . Negative_regulation MAPK9 TNF 15763380 1383462 Furthermore , pretreatment with oxymatrine significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet-to-dry weight ratio , decreases in serum level and *inhibition* of phosphorylated p38 [MAPK] . Negative_regulation MAPK9 TNF 15952594 1421650 Pretreatment of EGCG significantly alleviated oleic acid induced lung injury accompanied by reduction of lung index and wet to dry weight ratio , decreased of level in serum and *inhibition* of phosphorylation of p38 [MAPK] . Negative_regulation MAPK9 TNF 17189827 1680123 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Negative_regulation MAPK9 TNF 17214640 1681832 Roxithromycin significantly inhibited induced c-Jun N-terminal kinase activation ( JNP ) and marginally *inhibited* extracellular signal regulated kinase ( ERK ) 1/2 activation , but not p38 [mitogen activated protein kinase] activation . Negative_regulation MAPK9 TNF 17438131 1742719 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Negative_regulation MAPK9 TNF 19086324 2000281 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 [MAPK] and NF-kappaB activities , and then overexpression , thus alleviating the inflammatory reaction . Negative_regulation MAPK9 TNF 19118509 2004868 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and and *inhibited* the phosphorylation of Akt , PKCdelta and p38 [mitogen activated protein kinase (MAPK)] . Negative_regulation MAPK9 TNF 19450605 2096925 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 [MAPK] and *inhibited* cardiac expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation MAPK9 TNF 21147093 2378314 LPS induced phosphorylation of I?Ba and p38 [MAPK] was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation MAPK9 TNF 23056531 2685416 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit a ( TNF-a production in cultured macrophages ) and in vitro [MAPK] p38a *inhibition* . Negative_regulation MAPK9 TNF 23066265 2685774 Doxycycline , nonsteroidal anti-inflammatory drugs ( NSAIDs ) , bisphosphonates , nitrous oxide ( NO ) synthase inhibitors , recombinant human interleukin-11 ( rhIL-11 ) , omega-3 fatty acid , mouse anti-human interleukin-6 receptor antibody ( MRA ) , [mitogen activated protein kinase (MAPK)] *inhibitors* , nuclear factor-kappa B (NF-kb) inhibitors , osteoprotegerin , and tumor necrosis factor antagonist ( ) are some of the therapeutic agents that have host modulation properties . Negative_regulation MAPK9 TNF 23518420 2777208 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and protein expression in the kidney , as well as *inhibiting* [p38MAPK] signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation MAPK9 TNF 24152910 2875275 It was found that thrombin down-regulates the HMGB1 mediated induction of both and IL-6 and *inhibits* the activation of both p38 [MAPK] and NF-?B in HUVECs pretreated with PC . Negative_regulation MAPK9 TNF 8665940 368994 Low concentrations ( 2 nM ) of okadaic acid , a serine/threonine phosphatase inhibitor , prevented *induced* inhibition of [MAPK] and restored insulin 's effect on MAPK activity , while orthovanadate ( a tyrosine phosphatase inhibitor ) , inhibitor 2 ( phosphatase-1 inhibitor ) and FK506 ( phosphatase-2B inhibitor ) were ineffective . Negative_regulation MAPKAPK2 TNF 9916683 587470 SB 203580 , a selective inhibitor of p38 , blocked p38 and [MAPKAPK-2] activation in the T cell clone but did not completely *inhibit* release . Negative_regulation MAPRE1 TNF 22025632 2508087 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation MAT2A FAS 19048023 2035386 Inhibition of [methionine adenosyltransferase II] *induces* FasL expression , formation and caspase-8 dependent apoptotic death in T leukemic cells . Negative_regulation MATK GNE 23873850 2849510 Here , we describe the characterization of , an ATP-competitive , selective , and orally bioavailable [ChK1] *inhibitor* . Negative_regulation MATK GNE 24038068 2862632 We finally compared the ability of a structurally related [CHK1] *inhibitor* , , to enhance the in vivo activity of gemcitabine , CPT-11 , and temozolomide in xenograft models . Negative_regulation MATK MAP2K6 17011495 1629128 Further , activation in the early embryo is cell cycle dependent and Raf independent and *increases* in response to ionizing radiation or in the absence of [Chk1] . Negative_regulation MATN1 IL1B 18381322 1892794 The data show that , even in the *presence* of , a specific , defined capacitively coupled electrical signal can result in significant upregulation of [cartilage matrix protein] expression and production while simultaneously significantly attenuating the upregulation of metalloproteinase expression . Negative_regulation MBD2 SYNM 6413080 30569 They include : ( i ) the presence of inhibitors of in extracts of low-activity strains , ( ii ) a sex bias in the Hikone-R strain in which the enzyme activity is confined to the females , ( iii ) the possibility that DMN treatment *induces* [DMN-demethylase] activity in the low-activity strains and ( iv ) the possibility that Hikone-R has a much more efficient DNA repair system than the other strains . Negative_regulation MBP IFI27 12773549 1095152 Previous studies from our laboratory showed that the overexpression of ( Kip1 ) *enhances* [myelin basic protein (MBP)] promoter activity . Negative_regulation MBP IL1B 16109311 1445235 Interestingly , both and TNF-alpha markedly *inhibited* the expression of MOG , CNPase , and PLP but not [MBP] , the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate ( PDTC ) . Negative_regulation MBP TNF 16109311 1445234 Interestingly , both IL-1beta and markedly *inhibited* the expression of MOG , CNPase , and PLP but not [MBP] , the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate ( PDTC ) . Negative_regulation MBS1 AXIN2 17373666 1741396 To study the functional *role* of in [MBs] , wild-type AXIN2 was overexpressed in MB cell lines in which the Wnt signaling pathway was activated by Wnt-3a . Negative_regulation MBTPS1 ARSA 21251196 2409382 Oral ( 500-mg single dose or 100 mg over 3 days ) *attenuated* [S1P] release from platelets in healthy human volunteers ex vivo . Negative_regulation MBTPS1 SPHK1 17379599 1735432 Overexpression of wild type , but not SphK2 wild type , *increased* the accumulation of intracellular [S1P] after exposure to extracellular S1P . Negative_regulation MBTPS1 SPHK1 22098666 2534755 Furthermore , overexpression of *increased* [S1P] levels , and the exogenous addition of S1P increased liver cell migration and invasion through the EDG1 receptor . Negative_regulation MCC CHI3L1 10784400 688247 similarly *reduced* [myeloma clonogenic colony (MCC)] formation in patient primary bone marrow cultures by 50 % ( 40-76 % ; n=6 ) . Negative_regulation MCL1 EPHB2 17890680 1843625 Analysis of Bcl-2 family proteins revealed phosphorylation of Bad at serine 112 as well as dependent *inhibition* of [Mcl-1] degradation . Negative_regulation MCL1 EPHB2 21598425 2430816 O. japonicus down-regulated [Mcl-1] protein levels and *inhibited* the phosphorylation of , suggesting that it mediates cell death in LX2 cells through the down-regulation of Mcl-1 protein via a MEK/ERK independent pathway . Negative_regulation MCL1 EPHB2 23741975 2909183 Combined treatment with rapamycin and IDA down-regulated Bcl-2 and [Mcl-1] , and *inhibited* the activation of phosphoinositide 3-kinase (PI3K)/mTOR and extracellular signal related kinase ( ) . Negative_regulation MCL1 EPHB2 24263101 2869759 Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal *dependent* suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of [Mcl-1] . Negative_regulation MCL1 MAP2K6 17652623 1780365 Inhibition of *resulted* in the up-regulation of the BH3-only proteins PUMA and Bim and down-regulation of the antiapoptotic protein [Mcl-1] . Negative_regulation MCL1 MAP2K6 21598425 2430822 O. japonicus down-regulated [Mcl-1] protein levels and *inhibited* the phosphorylation of , suggesting that it mediates cell death in LX2 cells through the down-regulation of Mcl-1 protein via a MEK/ERK independent pathway . Negative_regulation MCL1 MAP2K6 22808163 2628946 Instead , cooperative mTOR complex 2 (mTORC2) and *inhibition* resulting in downregulation of the pro-survival protein [MCL-1] was found to be critical for combination induced apoptosis . Negative_regulation MCL1 SPHK1 17686057 1781502 IL-6 stimulation or retroviral mediated overexpression of in MM cells *resulted* in increased intracellular SPHK activity and upregulation of [myeloid cell leukaemia-1 (Mcl-1)] , leading to increased cell proliferation and survival . Negative_regulation MCL1 TNFSF10 17909059 1803586 Similarly , inhibition of the receptor mediated apoptotic cascade with a caspase-8 dominant negative mutant significantly blocked *induced* lethality but not [Mcl-1] down-regulation or Bak/Bax conformational change , indicating that TRAIL mediated receptor pathway activation is required for maximal lethality . Negative_regulation MCTS1 EPHB2 17416211 1777823 While [MCT-1] gene knockdown or pathway *inhibition* dramatically reduced MAPK phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Negative_regulation MCTS1 MAP2K6 17416211 1777829 While [MCT-1] gene knockdown or pathway *inhibition* dramatically reduced MAPK phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Negative_regulation MDM2 ID1 16506209 1554980 Ectopic expression *resulted* in increased serum independent cell growth and G1-S phase transition , as well as up-regulation of [mouse double minute 2 (MDM2)] and down-regulation of p21Waf1/Cip1 protein expressions in the transfectant clones in a p53 independent manner . Negative_regulation MDM2 MAP2K6 15723837 1396218 Here we show that , in human breast cancer epithelial cells , *dependent* regulation of [Hdm2] expression also occurs at a post-transcriptional level . Negative_regulation MDM2 TNFSF10 11992615 938781 In addition , combined and wortmannin treatment *resulted* in cleavage of several proteins : PARP , Akt , p21/WAF1 , and [MDM2] as well as dephosphorylation of Akt . Negative_regulation MED1 ADRB2 8388911 220308 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED1 CD14 16574244 1582614 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED1 EPHB2 19755425 2158581 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Negative_regulation MED1 F2R 14597986 1161022 decreased by approximately 8 % ( p < 0.001 ) within 2 h after endotoxin infusion and stayed at those levels until 6 h. Concomitantly , [TRAP] *induced* P-selectin expression maximally decreased by 18 % ( p < 0.001 ) at 6 h . Negative_regulation MED1 F2R 9141614 428453 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED1 FOXO1 22342903 2668576 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED1 HSD11B2 20544861 2271825 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED1 LBP 16574244 1582615 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED1 MSX1 17130681 1653112 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED1 TNF 14550746 1152720 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED10 ADRB2 8388911 220303 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED10 CD14 16574244 1582602 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED10 F2R 9141614 428448 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED10 FOXO1 22342903 2668508 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED10 HSD11B2 20544861 2271820 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED10 LBP 16574244 1582603 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED10 MSX1 17130681 1653104 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED10 TNF 14550746 1152716 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED11 ADRB2 8388911 220306 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED11 CD14 16574244 1582611 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED11 F2R 9141614 428451 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED11 FOXO1 22342903 2668529 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED11 HSD11B2 20544861 2271823 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED11 LBP 16574244 1582612 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED11 MSX1 17130681 1653110 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED11 TNF 14550746 1152719 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED12 CD14 16574244 1582527 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED12 EPHB2 19755425 2158553 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Negative_regulation MED12 F2R 14597986 1161016 decreased by approximately 8 % ( p < 0.001 ) within 2 h after endotoxin infusion and stayed at those levels until 6 h. Concomitantly , [TRAP] *induced* P-selectin expression maximally decreased by 18 % ( p < 0.001 ) at 6 h . Negative_regulation MED12 LBP 16574244 1582528 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED12 MSX1 17130681 1653054 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED12 TNF 14550746 1152691 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED13 ADRB2 8388911 220290 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED13 CD14 16574244 1582557 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED13 EPHB2 19755425 2158563 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Negative_regulation MED13 F2R 9141614 428435 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED13 FOXO1 22342903 2668417 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED13 HSD11B2 20544861 2271807 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED13 LBP 16574244 1582558 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED13 MSX1 17130681 1653074 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED13 TNF 14550746 1152701 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED13L ADRB2 8388911 220291 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED13L CD14 16574244 1582560 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED13L F2R 9141614 428436 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED13L FOXO1 22342903 2668424 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED13L HSD11B2 20544861 2271808 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED13L LBP 16574244 1582561 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED13L MSX1 17130681 1653076 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED13L TNF 14550746 1152702 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED14 ADRB2 8388911 220295 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED14 CD14 16574244 1582572 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED14 EPHB2 19755425 2158567 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Negative_regulation MED14 F2R 14597986 1161020 decreased by approximately 8 % ( p < 0.001 ) within 2 h after endotoxin infusion and stayed at those levels until 6 h. Concomitantly , [TRAP] *induced* P-selectin expression maximally decreased by 18 % ( p < 0.001 ) at 6 h . Negative_regulation MED14 F2R 9141614 428440 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED14 FOXO1 22342903 2668452 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED14 HSD11B2 20544861 2271812 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED14 LBP 16574244 1582573 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED14 MSX1 17130681 1653084 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED14 TNF 14550746 1152706 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED15 ADRB2 8388911 220284 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED15 CD14 16574244 1582530 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED15 EPHB2 19755425 2158555 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Negative_regulation MED15 F2R 9141614 428429 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED15 FOXO1 22342903 2668375 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED15 HSD11B2 20544861 2271801 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED15 LBP 16574244 1582531 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED15 MSX1 17130681 1653056 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED15 TNF 14550746 1152692 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED16 ADRB2 8388911 220286 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED16 CD14 16574244 1582539 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED16 F2R 14597986 1161017 decreased by approximately 8 % ( p < 0.001 ) within 2 h after endotoxin infusion and stayed at those levels until 6 h. Concomitantly , [TRAP] *induced* P-selectin expression maximally decreased by 18 % ( p < 0.001 ) at 6 h . Negative_regulation MED16 F2R 9141614 428431 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED16 FOXO1 22342903 2668389 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED16 HSD11B2 20544861 2271803 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED16 LBP 16574244 1582540 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED16 MSX1 17130681 1653062 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED16 TNF 14550746 1152695 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED17 ADRB2 8388911 220297 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED17 CD14 16574244 1582578 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED17 EPHB2 19755425 2158571 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Negative_regulation MED17 F2R 14597986 1161021 decreased by approximately 8 % ( p < 0.001 ) within 2 h after endotoxin infusion and stayed at those levels until 6 h. Concomitantly , [TRAP] *induced* P-selectin expression maximally decreased by 18 % ( p < 0.001 ) at 6 h . Negative_regulation MED17 F2R 9141614 428442 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED17 FOXO1 22342903 2668466 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED17 HSD11B2 20544861 2271814 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED17 LBP 16574244 1582579 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED17 MSX1 17130681 1653088 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED17 TNF 14550746 1152708 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED18 ADRB2 8388911 220302 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED18 CD14 16574244 1582599 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED18 F2R 9141614 428447 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED18 FOXO1 22342903 2668501 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED18 HSD11B2 20544861 2271819 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED18 LBP 16574244 1582600 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED18 MSX1 17130681 1653102 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED18 TNF 14550746 1152715 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED19 ADRB2 8388911 220305 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED19 CD14 16574244 1582608 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED19 F2R 9141614 428450 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED19 FOXO1 22342903 2668522 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED19 HSD11B2 20544861 2271822 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED19 LBP 16574244 1582609 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED19 MSX1 17130681 1653108 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED19 TNF 14550746 1152718 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED20 ADRB2 8388911 220285 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED20 CD14 16574244 1582536 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED20 F2R 9141614 428430 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED20 FOXO1 22342903 2668382 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED20 HSD11B2 20544861 2271802 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED20 LBP 16574244 1582537 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED20 MSX1 17130681 1653060 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED20 TNF 14550746 1152694 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED21 ADRB2 8388911 220282 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED21 CD14 16574244 1582521 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED21 F2R 9141614 428427 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED21 FOXO1 22342903 2668328 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED21 HSD11B2 20544861 2271799 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED21 LBP 16574244 1582522 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED21 MSX1 17130681 1653050 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED21 TNF 14550746 1152689 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED22 ADRB2 8388911 220283 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED22 CD14 16574244 1582524 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED22 F2R 9141614 428428 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED22 FOXO1 22342903 2668335 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED22 HSD11B2 20544861 2271800 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED22 LBP 16574244 1582525 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED22 MSX1 17130681 1653052 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED22 TNF 14550746 1152690 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED23 ADRB2 8388911 220296 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED23 CD14 16574244 1582575 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED23 EPHB2 19755425 2158569 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Negative_regulation MED23 F2R 9141614 428441 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED23 FOXO1 22342903 2668459 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED23 HSD11B2 20544861 2271813 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED23 LBP 16574244 1582576 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED23 MSX1 17130681 1653086 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED23 TNF 14550746 1152707 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED24 ADRB2 8388911 220292 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED24 CD14 16574244 1582563 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED24 EPHB2 19755425 2158565 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Negative_regulation MED24 F2R 14597986 1161018 decreased by approximately 8 % ( p < 0.001 ) within 2 h after endotoxin infusion and stayed at those levels until 6 h. Concomitantly , [TRAP] *induced* P-selectin expression maximally decreased by 18 % ( p < 0.001 ) at 6 h . Negative_regulation MED24 F2R 9141614 428437 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED24 FOXO1 22342903 2668431 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED24 HSD11B2 20544861 2271809 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED24 LBP 16574244 1582564 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED24 MSX1 17130681 1653078 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED24 TNF 14550746 1152703 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED25 ADRB2 8388911 220304 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED25 CD14 16574244 1582605 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED25 EPHB2 19755425 2158577 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Negative_regulation MED25 F2R 9141614 428449 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED25 FOXO1 22342903 2668515 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED25 HSD11B2 20544861 2271821 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED25 LBP 16574244 1582606 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED25 MSX1 17130681 1653106 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED25 TNF 14550746 1152717 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED26 ADRB2 8388911 220298 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED26 CD14 16574244 1582581 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED26 EPHB2 19755425 2158573 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Negative_regulation MED26 F2R 9141614 428443 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED26 FOXO1 22342903 2668473 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED26 HSD11B2 20544861 2271815 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED26 LBP 16574244 1582582 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED26 MSX1 17130681 1653090 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED26 TNF 14550746 1152709 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED27 ADRB2 8388911 220299 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED27 CD14 16574244 1582584 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED27 F2R 9141614 428444 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED27 FOXO1 22342903 2668480 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED27 HSD11B2 20544861 2271816 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED27 LBP 16574244 1582585 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED27 MSX1 17130681 1653092 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED27 TNF 14550746 1152710 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED28 CD14 16574244 1582593 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED28 LBP 16574244 1582594 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED28 MSX1 17130681 1653098 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED28 TNF 14550746 1152713 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED29 ADRB2 8388911 220294 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED29 CD14 16574244 1582569 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED29 F2R 9141614 428439 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED29 FOXO1 22342903 2668445 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED29 HSD11B2 20544861 2271811 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED29 LBP 16574244 1582570 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED29 MSX1 17130681 1653082 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED29 TNF 14550746 1152705 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED30 ADRB2 8388911 220293 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED30 CD14 16574244 1582566 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED30 F2R 9141614 428438 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED30 FOXO1 22342903 2668438 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED30 HSD11B2 20544861 2271810 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED30 LBP 16574244 1582567 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED30 MSX1 17130681 1653080 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED30 TNF 14550746 1152704 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED31 ADRB2 8388911 220301 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED31 CD14 16574244 1582590 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED31 F2R 9141614 428446 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED31 FOXO1 22342903 2668494 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED31 HSD11B2 20544861 2271818 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED31 LBP 16574244 1582591 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED31 MSX1 17130681 1653096 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED31 TNF 14550746 1152712 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED4 ADRB2 8388911 220287 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED4 CD14 16574244 1582545 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED4 EPHB2 19755425 2158557 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Negative_regulation MED4 F2R 9141614 428432 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED4 FOXO1 22342903 2668396 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED4 HSD11B2 20544861 2271804 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED4 LBP 16574244 1582546 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED4 MSX1 17130681 1653066 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED4 TNF 14550746 1152697 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED6 ADRB2 8388911 220288 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED6 CD14 16574244 1582551 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED6 EPHB2 19755425 2158559 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Negative_regulation MED6 F2R 9141614 428433 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED6 FOXO1 22342903 2668403 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED6 HSD11B2 20544861 2271805 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED6 LBP 16574244 1582552 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED6 MSX1 17130681 1653070 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED6 TNF 14550746 1152699 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED7 ADRB2 8388911 220300 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED7 CD14 16574244 1582587 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED7 EPHB2 19755425 2158575 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Negative_regulation MED7 F2R 9141614 428445 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED7 FOXO1 22342903 2668487 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED7 HSD11B2 20544861 2271817 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED7 LBP 16574244 1582588 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED7 MSX1 17130681 1653094 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED7 TNF 14550746 1152711 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED8 ADRB2 8388911 220289 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation MED8 CD14 16574244 1582554 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED8 EPHB2 19755425 2158561 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Negative_regulation MED8 F2R 9141614 428434 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation MED8 FOXO1 22342903 2668410 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation MED8 HSD11B2 20544861 2271806 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation MED8 LBP 16574244 1582555 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED8 MSX1 17130681 1653072 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED8 TNF 14550746 1152700 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MED9 CD14 16574244 1582596 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED9 LBP 16574244 1582597 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Negative_regulation MED9 MSX1 17130681 1653100 The release of each chemical [mediator] was *inhibited* by <10-9-10-8M SX> but not by 10-10-10-7M FP . Negative_regulation MED9 TNF 14550746 1152714 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Negative_regulation MEFV ID1 20956996 2382154 OSM downregulated myocyte enhancer binding factor 2A ( MEF2A ) , upregulated the expression of and Id2 , and *inhibited* the transcriptional activity of MyoD and [MEF2] . Negative_regulation MEFV TNF 22736074 2719267 The *role* of and PAI-1 gene polymorphisms in familial [Mediterranean fever] . Negative_regulation MEP1A TNF 22326557 2586496 to assess if they are regulated by tumor necrosis factor-a (TNF-a) , and finally to reveal if CDX2 is involved in a *induced* down-regulation of [MEP1A] . Negative_regulation MET PLAT 17538930 1751778 One potential mechanism for these effects is that both tPA deficiency and *reduce* hepatocyte growth factor (HGF) activation and [c-Met] phosphorylation in the liver after BDL . Negative_regulation MFN2 PGC 23449689 2771480 *mediated* [mitofusin-2] deficiency in female rats and humans with pulmonary arterial hypertension . Negative_regulation MFN2 TNF 16123358 1449354 Based on the presence of mitochondrial dysfunction in insulin-resistant conditions , we have examined whether Mfn2 expression is dysregulated in skeletal muscle from obese or nonobese type 2 diabetic subjects , whether muscle [Mfn2] expression is *regulated* by body weight loss , and the potential regulatory role of or interleukin-6 . Negative_regulation MGAM HCL1 6414283 31719 A highly purified solution of rat and human maltase/glucoamylase was capable of degrading a starch solution , while 40 mM ( a known [maltase/glucoamylase] *inhibitor* ) completely abolished the enzyme activity . Negative_regulation MGAM HCL2 6414283 31720 A highly purified solution of rat and human maltase/glucoamylase was capable of degrading a starch solution , while 40 mM ( a known [maltase/glucoamylase] *inhibitor* ) completely abolished the enzyme activity . Negative_regulation MGAM HCL3 6414283 31721 A highly purified solution of rat and human maltase/glucoamylase was capable of degrading a starch solution , while 40 mM ( a known [maltase/glucoamylase] *inhibitor* ) completely abolished the enzyme activity . Negative_regulation MICA EPHB2 23308050 2712564 Furthermore , overexpression of constitutively active in ARK *resulted* in increased [MICA/B] and ULBP2 expressions and enhanced NK cell lysis . Negative_regulation MIP ARF1 20101237 2226395 *induced* downregulation of [Mip130/LIN-9] protein levels mediates a positive feedback that leads to increased expression of p16Ink4a and p19Arf . Negative_regulation MIP ARF3 20101237 2226396 *induced* downregulation of [Mip130/LIN-9] protein levels mediates a positive feedback that leads to increased expression of p16Ink4a and p19Arf . Negative_regulation MIP ARF4 20101237 2226397 *induced* downregulation of [Mip130/LIN-9] protein levels mediates a positive feedback that leads to increased expression of p16Ink4a and p19Arf . Negative_regulation MIP ARF5 20101237 2226398 *induced* downregulation of [Mip130/LIN-9] protein levels mediates a positive feedback that leads to increased expression of p16Ink4a and p19Arf . Negative_regulation MIP ARF6 20101237 2226399 *induced* downregulation of [Mip130/LIN-9] protein levels mediates a positive feedback that leads to increased expression of p16Ink4a and p19Arf . Negative_regulation MIP HFE 24643698 2938520 Using transient HFE transfection assays in a model of APCs , we show that WT ( HFEWT ) , but not C282Y mutated HFE , *inhibits* secretion of [MIP-1ß] from antigen-specific CD8 ( + ) T lymphocytes . Negative_regulation MIP IL10 10385657 625673 In addition , *reduced* serum levels of TNF-alpha and [MIP-2] . Negative_regulation MIP IL17RA 20042461 2211318 Mesangial cells expressed IL-17RA and IL-17RC , and the IL-17A mediated MCP-1 and [MIP-2] release was significantly *blocked* by soluble . Negative_regulation MIP IL2RA 23648818 2791103 However , both and CD25- T cells *suppressed* MIP-1a and [MIP-1ß] secretion to the same extent . Negative_regulation MIP NA 17139376 1653609 In addition , significantly *reduced* IL-6 and [MIP-2] expression and injury in the kidney I/R model . Negative_regulation MIP PITX3 21698120 2446720 Therefore , our data suggest that is *involved* in direct regulation of [MIP/AQP0] expression and that the alteration of MIP/AQP0 expression is likely to contribute to the lens phenotype in cataract patients with PITX3 mutations . Negative_regulation MIP SP3 9421492 481201 Supershift experiments with lens nuclear extracts indicated that Sp3 is also able to interact with this regulatory element , suggesting that Sp1 and may be *involved* in regulation of transcription of the [MIP] gene in the lens . Negative_regulation MIP TNPO1 18768846 1957122 Cathelicidin inhibited HA induced release from mouse bone marrow derived macrophages in a CD44 dependent manner but did not *inhibit* MALP2 induced [MIP-2] release . Negative_regulation MIP ZFP36 17392586 1665327 Down-regulation of expression *results* in enhanced IL-12 and [MIP-2] production and reduced MIP-3alpha synthesis in activated macrophages . Negative_regulation MIPEP IL1B 14746807 1182110 We examined the *role* of , a multifunctional cytokine , in regulating the expression of [macrophage inflammatory protein (MIP)-1beta] in human hepatocytes ( Huh7 and HepG2 ) . Negative_regulation MIPEP ITGB2 9759893 536640 As expected , cross linking of on macrophages with Ab *resulted* in generation of TNF-alpha and [MIP-2] . Negative_regulation MIPEP TNF 10799303 691104 Moreover , it was observed that dexamethasone treatment inhibited endothelial cell expression of [MIP-2] in *response* to stimulation and markedly reduced the number of adherent neutrophils . Negative_regulation MIPEP TNF 10991927 732888 Notably , 2 h pretreatment with dexamethasone ( 10 mg kg ( -1 ) , i.p. ) reduced [MIP-2] expression by 65 % in *response* to ( 0.1 microg ml(-1) ) . Negative_regulation MIR191 EPHB2 22198386 2575038 We demonstrate that induction of EGR1 involves *mediated* down-regulation of [microRNA-191] and phosphorylation of the ETS2 repressor factor (ERF) repressor , which subsequently leaves the nucleus . Negative_regulation MITF EPHB2 16781122 1599361 These results suggest that hinokitiol induced phosphorylation *reduces* [MITF] and TYR transcription , and mediates the action of hinokitiol on melanogenesis . Negative_regulation MITF EPHB2 18478239 1951647 a inhibitor , PD98059 , almost completely *attenuated* the MbetaCD mediated inhibition of melanin synthesis and down-regulation of [MITF] and tyrosinase expression . Negative_regulation MITF EPHB2 23792203 2820534 Furthermore , a specific pathway inhibitor , PD98059 , blocked GGA induced melanin reduction and then *prevented* downregulation of [MITF] and tyrosinase by GGA . Negative_regulation MLS TP63 16224147 1469400 To obtain new insights into the *role* of in [malignant lymphomas (MLs)] , immunohistochemical staining for p63 and p53 was performed in 126 cases of MLs . Negative_regulation MLST8 DAPK1 18974095 2015059 DAPK ( +/- ) mouse embryo fibroblasts have attenuated [mTORC1] signaling compared with DAPK+/+ counterparts , and overexpression of in DAPK ( +/- ) MEFs *stimulates* mTORC1 activity . Negative_regulation MLST8 EPHB2 22715163 2634047 Lovastatin alone significantly reduced MPC and MTT cell viability at therapeutically relevant doses and *inhibited* both and AKT signalling , but increased [mTORC1/p70S6K] signalling . Negative_regulation MLST8 EPHB2 23431403 2744406 Absence of kinase suppressor of Ras 1 (KSR1) , a scaffold protein of the ERK signaling pathway , or inhibition of *resulted* in decreased [mTORC1] activity following T cell activation . Negative_regulation MLST8 FBXO32 24002653 2856142 To accomplish this goal , in vivo transfection of plasmid DNA was used to create transient transgenic mouse skeletal muscles , and our results show for the first time that Smad3 expression is sufficient to stimulate promoter activity , *inhibit* [Akt/mTOR signaling] and protein synthesis , and induce muscle fiber atrophy . Negative_regulation MLST8 FOXO1 20412774 2246452 Activated *inhibits* [mTORC1] by TSC2 dependent and TSC2 independent mechanisms . Negative_regulation MLST8 FOXO1 20412774 2246466 Thus , under stress conditions , *inhibits* the anabolic activity of [mTORC1] , a major consumer of cellular energy , while activating Akt , which increases cellular energy metabolism , thereby maintaining cellular energy homeostasis . Negative_regulation MLST8 FOXO1 23800068 2802898 This hypothesis postulates that antiacne agents either enhance nuclear activity or *inhibit* [mTORC1] . Negative_regulation MLST8 TLR7 24251781 2903585 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , PI3K/AkT inhibition , IKK/JNK inhibition , [mTORC1] *inhibition* , JAK/STAT inhibition , suppression , and ACE inhibition . Negative_regulation MLXIPL FOXO1 23803610 2824464 Moreover , blocked glucose induced TXNIP expression and *reduced* glucose induced [ChREBP] binding at the TXNIP promoter without affecting ChREBP expression or nuclear localization , suggesting that FOXO1 may compete with ChREBP for binding to the TXNIP promoter . Negative_regulation MLYCD CD14 12911858 1122176 Soluble ( sCD14 ) , in the circulation , binds to LPS and *blocks* LPS binding to [mCD14] . Negative_regulation MMP1 CLU 23747716 2828098 Kidney toxicity was investigated after 13 weeks of administering the complex orally to rats with parameters including blood urea nitrogen ( BUN ) , creatinine , and kidney damage biomarkers , beta-2-microglobulin ( ß2m ) , glutathione S-transferase alpha ( GST-a ) , kidney injury molecule 1 (KIM-1) , tissue *inhibitor* of [matrix metalloproteinase 1] ( TIMP-1 ) , vascular endothelial growth factor ( VEGF ) , calbindin , , cystatin C , neutrophil gelatinase associated lipocalin ( NGAL ) , and osteopontin . Negative_regulation MMP1 CTGF 23827951 2820811 stimulation *resulted* in the significant production of IL-6 , IL-8 , C-C motif ligand 2 (CCL2) , CCL20 , [MMP-1] and MMP-3 in FLSs in the presence , but not in the absence , of IL-1ß . Negative_regulation MMP1 ENTPD8 23941770 2861786 The ATP mediated MMP-1 inhibition was restored in the presence of POM-1 , a specific ENTPD inhibitor , suggesting that was *involved* in the [MMP-1] inhibition . Negative_regulation MMP1 EPHB2 14634122 1170900 Whereas millimolar salicylates inhibited both and MMP-1 , nonsalicylate COX and selective COX-2 inhibitors *enhanced* stimulated [MMP-1] release . Negative_regulation MMP1 EPHB2 14634122 1170903 Addition of exogenous PGE ( 1 ) or PGE ( 2 ) inhibited [MMP-1] , reversed the effects of COX inhibitors , and *inhibited* activation , suggesting that COX-2 activity tonically inhibits MMP-1 production via ERK inhibition by E PGs . Negative_regulation MMP1 EPHB2 15640153 1381325 PGEs enhanced activation and MMP-1 secretion in response to EGF but *inhibited* Erk and [MMP-1] when TNF-alpha and IL-1beta were the stimuli , indicating that the effects of PGEs on gastric cell responses are context dependent . Negative_regulation MMP1 EPHB2 15930517 1433897 Pretreatment of HDFs with EPA inhibited UV-induced [MMP-1] expression in a dose dependent manner and also *inhibited* the UV-induced activation of and JNK by inhibiting ERK kinase ( MEK1 ) and SAPK/ERK kinase 1 (SEK1) activation , respectively . Negative_regulation MMP1 EPHB2 16101130 1444161 R115777 +/- paclitaxel inhibited HDJ-2 farnesylation , up-regulated RhoB , transiently lowered ( P ) and ( P ) Akt/Akt , reduced Raf-1 and MEK and *inhibited* secretion of VEGF and [MMP-1] . Negative_regulation MMP1 EPHB2 16413539 1514342 Pretreatment of HSFs with 2',4',7-THF inhibited UV-induced [MMP-1] expression in a dose dependent manner , and also *inhibited* the UV-induced activations of and JNK by inhibiting MEK1 and SEK1 activation , respectively . Negative_regulation MMP1 EPHB2 18684973 1949193 , Jnk , and NF-kappaB inhibitors had no effect on annexin-1 secretion stimulated by TNF-alpha but *inhibited* [MMP-1] secretion in response to Ac2-26 , indicating that these molecules signal downstream of annexin-1 . Negative_regulation MMP1 EPHB2 21056074 2370803 The results showed that CAE stimulated type I procollagen expression , inhibited [MMP-1] , -3 , -9 expression and *inhibited* the phosphorylation of JNK , and p38 . Negative_regulation MMP1 F2R 21093894 2376975 Furthermore , MMP-1 and were both significantly *induced* by LPA ( 20 µM ) , and siRNA silencing of [MMP-1] and PAR1 both significantly reduced LPA 's invasion promoting effect in DOV13 cells ( p < 0.05 ) . Negative_regulation MMP1 FAS 11980895 954077 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of [MMP] and cytochrome c release . Negative_regulation MMP1 HBEGF 17322418 1747778 Inhibition of heparin binding EGF-like growth factor ( ) release by CRM-197 and *inhibition* of [matrix metalloproteinases (MMP)] by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation . Negative_regulation MMP1 IL1B 12118680 964816 To determine the effects of prostaglandin E2 ( PGE2 ) on recombinant equine *stimulated* expression of matrix metalloproteinases ( MMP 1 , MMP 3 , MMP 13 ) and tissue inhibitor of [matrix metalloproteinase 1] ( TIMP 1 ) in vitro . Negative_regulation MMP1 IL1B 12880581 1115755 The effects of DHEA on the gene expressions of [MMP-1] and -3 were more prominent in the *presence* of , in which DHEA suppressed not only MMP-1 , but also MMP-3 at the lower concentrations , 10 and 50 micro M , respectively . Negative_regulation MMP1 IL1B 16122880 1461081 A dose dependent inhibition of and TPA *stimulated* [MMP] activity by gallium nitrate at increasing concentrations occurs , demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis . Negative_regulation MMP1 MAP2K6 16101130 1444170 R115777 +/- paclitaxel inhibited HDJ-2 farnesylation , up-regulated RhoB , transiently lowered ( P ) ERK/ERK and ( P ) Akt/Akt , reduced Raf-1 and and *inhibited* secretion of VEGF and [MMP-1] . Negative_regulation MMP1 MMP28 17907155 1812553 Inhibition of activity by MMP inhibitor GM1489 and *inhibition* of [MMP-1] expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly restored HGF inhibited collagen and CTGF accumulation . Negative_regulation MMP1 MMP28 9223295 442763 Furthermore , a chimera of the TM/cytoplasmic domain of MT-MMP ( TMMT-MMP ) with tissue *inhibitor* of [MMP 1] ( ) directed the TIMP-1 molecule to invadopodia . Negative_regulation MMP1 MMP7 17907155 1812568 Inhibition of activity by MMP inhibitor GM1489 and *inhibition* of [MMP-1] expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly restored HGF inhibited collagen and CTGF accumulation . Negative_regulation MMP1 MMP7 9223295 442778 Furthermore , a chimera of the TM/cytoplasmic domain of MT-MMP ( TMMT-MMP ) with tissue *inhibitor* of [MMP 1] ( ) directed the TIMP-1 molecule to invadopodia . Negative_regulation MMP1 PLAT 22244977 2564134 We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle , delayed tPA alone , or combined ( 10 mg/kg , i.v. ) plus GM6001 ( 100 mg/kg , i.p. ) , a broad-spectrum [MMP] *inhibitor* . Negative_regulation MMP1 PLAU 12117412 997453 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Negative_regulation MMP1 PLAU 14515149 1147032 In conclusion , we postulate that 15d-PGJ ( 2 ) may differently regulate the synthesis of proteases involved in angiogenesis : it upregulates [MMP-1] expression in HMEC-1 through induction of oxidative stress , and *inhibits* synthesis partly by activation of PPARgamma . Negative_regulation MMP1 PLAU 24418973 2942375 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 in the conditioned media . Negative_regulation MMP1 SPHK1 16278291 1502524 In this study , we investigated the *role* of in the regulation of expression of [matrix metalloproteinase 1 (MMP1)] in dermal fibroblasts , a key event in regulation of extra cellular matrix . Negative_regulation MMP1 SPHK1 16278291 1502527 We show that overexpression of *up-regulated* MMP1 protein , MMP1 mRNA , and [MMP1] promoter activity , and this action of SphK1 required activation of the ERK1/2-Ets1 and NF-kappaB pathways . Negative_regulation MMP1 TFPI2 20015200 2488999 Moreover , down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in a ( 1 ) integrin on cell surface , and *increased* [MMP] expression ( mainly MMP-1 and -3 ) contributing to cancer cell invasion through basement membrane components . Negative_regulation MMP1 TNF 12506070 1038334 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in [MMP] and TIMP expression . Negative_regulation MMP1 TNF 15145598 1247697 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of [MMP] and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation MMP1 TNF 15641080 1363003 Independent analyses of gene expression in cultured cartilage from 9 other OA patients revealed that or MMP-1 blockade , either alone and/or in] combination , frequently *down-regulated* [MMP-3 , MMP-13 , and IL-1 expression . Negative_regulation MMP1 TNF 15663564 1350370 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Negative_regulation MMP1 TNF 16106101 1444990 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Negative_regulation MMP1 TNF 17031853 1683074 Taken together , these findings indicate that Raf-1/MEK/ERK signaling pathway plays a crucial role in the production of MMP-1 in HCS-2/8 cells in *response* to , and that the produced PGE ( 2 ) downregulates the expression of [MMP-1] by blockage of TNF-alpha induced Raf-1 activation through EP4-PGE ( 2 ) receptor activation . Negative_regulation MMP1 TNF 17223661 1765543 Predominant activation of MAP kinases and pro-destructive/pro-inflammatory features by in early-passage synovial fibroblasts via TNF receptor-1 : failure of p38 inhibition to *suppress* [matrix metalloproteinase-1] in rheumatoid arthritis . Negative_regulation MMP1 TNF 17469134 1737468 OSM and stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP1 TNF 19281093 2007616 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Negative_regulation MMP1 TNF 22202225 2518996 In addition , we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as ( TNF-B ) , interferon-alpha ( IFN-a ) , transforming growth factor-beta (TGF-B) , interleukins ( IL ) such as IL1-B and IL-6 , as well as [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( TIMP ) . Negative_regulation MMP1 TNF 24062615 2846670 We have demonstrated that budesonide concentration-dependently ( 10 ( -10 ) -10 ( -7 ) M ) inhibited IL-6 , IL-8 , [MMP-1] , and MMP-3 release by HFL-1 cells in *response* to IL-1ß plus . Negative_regulation MMP1 TNFSF10 23582782 2778425 however , the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus *induced* loss of [MMP] and apoptosis . Negative_regulation MMP10 FAS 11980895 954078 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of [MMP] and cytochrome c release . Negative_regulation MMP10 HBEGF 17322418 1747779 Inhibition of ( HB-EGF ) release by CRM-197 and *inhibition* of [matrix metalloproteinases (MMP)] by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation . Negative_regulation MMP10 IL1B 16122880 1461082 A dose dependent inhibition of and TPA *stimulated* [MMP] activity by gallium nitrate at increasing concentrations occurs , demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis . Negative_regulation MMP10 PLAT 22244977 2564135 We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle , delayed tPA alone , or combined ( 10 mg/kg , i.v. ) plus GM6001 ( 100 mg/kg , i.p. ) , a broad-spectrum [MMP] *inhibitor* . Negative_regulation MMP10 PLAU 12117412 997454 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Negative_regulation MMP10 PLAU 24418973 2942376 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 in the conditioned media . Negative_regulation MMP10 TFPI2 20015200 2489000 Moreover , down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in a ( 1 ) integrin on cell surface , and *increased* [MMP] expression ( mainly MMP-1 and -3 ) contributing to cancer cell invasion through basement membrane components . Negative_regulation MMP10 TNF 12506070 1038335 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in [MMP] and TIMP expression . Negative_regulation MMP10 TNF 15145598 1247698 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of [MMP] and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation MMP10 TNF 15663564 1350371 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Negative_regulation MMP10 TNF 16106101 1444991 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Negative_regulation MMP10 TNF 17469134 1737470 OSM and stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP10 TNF 19281093 2007617 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Negative_regulation MMP10 TNF 22202225 2518997 In addition , we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as ( TNF-B ) , interferon-alpha ( IFN-a ) , transforming growth factor-beta (TGF-B) , interleukins ( IL ) such as IL1-B and IL-6 , as well as [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( TIMP ) . Negative_regulation MMP10 TNFSF10 23582782 2778426 however , the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus *induced* loss of [MMP] and apoptosis . Negative_regulation MMP11 FAS 11980895 954079 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of [MMP] and cytochrome c release . Negative_regulation MMP11 GNE 16847058 1606779 Overexpression of recombinant in human embryonic kidney ( HEK AD293 ) cells *led* to an increase in mRNA levels for [ST3Gal5] ( GM3 synthase ) and ST8Sia1 ( GD3 synthase ) as well as the biosynthetic products of these sialyltransferases , the GM3 and GD3 gangliosides . Negative_regulation MMP11 HBEGF 17322418 1747780 Inhibition of heparin binding EGF-like growth factor ( ) release by CRM-197 and *inhibition* of [matrix metalloproteinases (MMP)] by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation . Negative_regulation MMP11 IL1B 16122880 1461083 A dose dependent inhibition of and TPA *stimulated* [MMP] activity by gallium nitrate at increasing concentrations occurs , demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis . Negative_regulation MMP11 PLAT 22244977 2564136 We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle , delayed tPA alone , or combined ( 10 mg/kg , i.v. ) plus GM6001 ( 100 mg/kg , i.p. ) , a broad-spectrum [MMP] *inhibitor* . Negative_regulation MMP11 PLAU 12117412 997455 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Negative_regulation MMP11 PLAU 24418973 2942377 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 in the conditioned media . Negative_regulation MMP11 TFPI2 20015200 2489001 Moreover , down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in a ( 1 ) integrin on cell surface , and *increased* [MMP] expression ( mainly MMP-1 and -3 ) contributing to cancer cell invasion through basement membrane components . Negative_regulation MMP11 TNF 12506070 1038336 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in [MMP] and TIMP expression . Negative_regulation MMP11 TNF 15145598 1247699 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of [MMP] and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation MMP11 TNF 15663564 1350372 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Negative_regulation MMP11 TNF 16106101 1444992 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Negative_regulation MMP11 TNF 17469134 1737472 OSM and stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP11 TNF 19281093 2007618 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Negative_regulation MMP11 TNF 22202225 2518998 In addition , we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as ( TNF-B ) , interferon-alpha ( IFN-a ) , transforming growth factor-beta (TGF-B) , interleukins ( IL ) such as IL1-B and IL-6 , as well as [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( TIMP ) . Negative_regulation MMP11 TNFSF10 23582782 2778427 however , the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus *induced* loss of [MMP] and apoptosis . Negative_regulation MMP12 ALOX5 16849505 1588483 Lastly , mechanistic insights are provided by demonstrating that IL-13 induced <5-LO> activation is *required* for optimal stimulation and activation of TGF-beta(1) and the inhibition of [matrix metalloproteinase-12] . Negative_regulation MMP12 FAS 11980895 954080 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of [MMP] and cytochrome c release . Negative_regulation MMP12 HBEGF 17322418 1747781 Inhibition of ( HB-EGF ) release by CRM-197 and *inhibition* of [matrix metalloproteinases (MMP)] by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation . Negative_regulation MMP12 IL1B 16122880 1461084 A dose dependent inhibition of and TPA *stimulated* [MMP] activity by gallium nitrate at increasing concentrations occurs , demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis . Negative_regulation MMP12 MMP28 19278250 2055672 ( 14 ) , a potent and selective [MMP-12] *inhibitor* , was derived from a potent matrix metalloprotease 2 and 13 inhibitor via lead optimization and has good physical properties and bioavailability . Negative_regulation MMP12 MMP28 23285156 2711764 Similar results were observed in the study using , a pharmacological *inhibitor* of [MMP-12] . Negative_regulation MMP12 MMP7 19278250 2055687 ( 14 ) , a potent and selective [MMP-12] *inhibitor* , was derived from a potent matrix metalloprotease 2 and 13 inhibitor via lead optimization and has good physical properties and bioavailability . Negative_regulation MMP12 MMP7 23285156 2711779 Similar results were observed in the study using , a pharmacological *inhibitor* of [MMP-12] . Negative_regulation MMP12 PLAT 22244977 2564137 We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle , delayed alone , or combined tPA ( 10 mg/kg , i.v. ) plus GM6001 ( 100 mg/kg , i.p. ) , a broad-spectrum [MMP] *inhibitor* . Negative_regulation MMP12 PLAU 12117412 997456 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Negative_regulation MMP12 PLAU 24418973 2942378 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 in the conditioned media . Negative_regulation MMP12 TFPI2 20015200 2489002 Moreover , down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in a ( 1 ) integrin on cell surface , and *increased* [MMP] expression ( mainly MMP-1 and -3 ) contributing to cancer cell invasion through basement membrane components . Negative_regulation MMP12 TNF 12506070 1038337 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in [MMP] and TIMP expression . Negative_regulation MMP12 TNF 15145598 1247700 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of [MMP] and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation MMP12 TNF 15663564 1350373 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Negative_regulation MMP12 TNF 16106101 1444993 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Negative_regulation MMP12 TNF 17469134 1737474 OSM and stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP12 TNF 19281093 2007619 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Negative_regulation MMP12 TNF 22202225 2518999 In addition , we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as ( TNF-B ) , interferon-alpha ( IFN-a ) , transforming growth factor-beta (TGF-B) , interleukins ( IL ) such as IL1-B and IL-6 , as well as [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( TIMP ) . Negative_regulation MMP12 TNFSF10 23582782 2778428 however , the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus *induced* loss of [MMP] and apoptosis . Negative_regulation MMP13 ANKRD1 24515436 2924081 We propose that , in association with factors such as nucleolin , *represses* [MMP13] transcription . Negative_regulation MMP13 CHI3L1 15015934 1251093 *suppressed* the cytokine induced secretion of MMP1 , MMP3 and [MMP13] , as well as secretion of the chemokine IL-8 . Negative_regulation MMP13 EPHB2 17941091 1866509 p38 inhibitor , SB203580 or JNK inhibitor , SP600125 but not inhibitor , PD98059 *attenuated* the US-induced [MMP-13] , c-Fos , and c-Jun expression ; Negative_regulation MMP13 EPHB2 20615395 2309885 GDNF induced [MMP-13] expression and glioma migration were *attenuated* by MEK/extracellular signal regulating kinase ( ERK ) and c-Jun N-terminal protein kinase (JNK) inhibitors , as well as and JNK dominant negative mutants . Negative_regulation MMP13 EPHB2 21278254 2409609 Activation of the Ras , Raf-1 , MEK , ERK , and NF-?B signaling pathways after IL-6 treatment was demonstrated , and IL-6 induced [MMP-13] expression and migration activity were *inhibited* by the specific inhibitor and mutant Ras , Raf-1 , MEK , , and NF-?B cascades . Negative_regulation MMP13 F2R 22610965 2614635 Finally , we demonstrated that either genetic ablation or pharmacological *inhibition* of [MMP-13] prevented isoproterenol dependent cardiac dysfunction in mice . Negative_regulation MMP13 FAS 11980895 954081 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of [MMP] and cytochrome c release . Negative_regulation MMP13 HBEGF 17322418 1747782 Inhibition of heparin binding EGF-like growth factor ( ) release by CRM-197 and *inhibition* of [matrix metalloproteinases (MMP)] by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation . Negative_regulation MMP13 IL1B 16122880 1461085 A dose dependent inhibition of and TPA *stimulated* [MMP] activity by gallium nitrate at increasing concentrations occurs , demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis . Negative_regulation MMP13 IL1B 18470577 1921585 Blocking expression with siRNA *suppressed* load induced both [MMP-13] mRNA expression and activity . Negative_regulation MMP13 MMP28 11774278 899584 The enhanced invasion capacity of [MMP-13] expressing HT-1080 cells was *dependent* on activity , as it was blocked by MMP inhibitor Batimastat ( BB-94 ) and tissue inhibitor of metalloproteinases-3 ( TIMP-3 ) . Negative_regulation MMP13 MMP7 11774278 899599 The enhanced invasion capacity of [MMP-13] expressing HT-1080 cells was *dependent* on activity , as it was blocked by MMP inhibitor Batimastat ( BB-94 ) and tissue inhibitor of metalloproteinases-3 ( TIMP-3 ) . Negative_regulation MMP13 MMP7 15103490 1301682 inhibition as well as *inhibition* of [MMP-13] and MMP-3 may be a useful preventive or therapeutic adjunct in colorectal cancer . Negative_regulation MMP13 PLAT 22244977 2564138 We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle , delayed tPA alone , or combined ( 10 mg/kg , i.v. ) plus GM6001 ( 100 mg/kg , i.p. ) , a broad-spectrum [MMP] *inhibitor* . Negative_regulation MMP13 PLAU 12117412 997457 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Negative_regulation MMP13 PLAU 24418973 2942379 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 in the conditioned media . Negative_regulation MMP13 TCN1 23368947 2853732 A promoter assay indicated that directly *inhibits* the activation of the PTH-responsive minimal promoter of [MMP-13] . Negative_regulation MMP13 TFPI2 20015200 2489003 Moreover , down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in a ( 1 ) integrin on cell surface , and *increased* [MMP] expression ( mainly MMP-1 and -3 ) contributing to cancer cell invasion through basement membrane components . Negative_regulation MMP13 TNF 12506070 1038338 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in [MMP] and TIMP expression . Negative_regulation MMP13 TNF 15145598 1247701 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of [MMP] and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation MMP13 TNF 15641080 1363005 Independent analyses of gene expression in cultured cartilage from 9 other OA patients revealed that or MMP-1 blockade , either alone and/or in combination , frequently *down-regulated* MMP-3 , [MMP-13] , and IL-1 expression . Negative_regulation MMP13 TNF 15663564 1350374 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Negative_regulation MMP13 TNF 16106101 1444994 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Negative_regulation MMP13 TNF 17469134 1737476 OSM and stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP13 TNF 19281093 2007620 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Negative_regulation MMP13 TNF 22202225 2519000 In addition , we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as ( TNF-B ) , interferon-alpha ( IFN-a ) , transforming growth factor-beta (TGF-B) , interleukins ( IL ) such as IL1-B and IL-6 , as well as [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( TIMP ) . Negative_regulation MMP13 TNFSF10 23582782 2778429 however , the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus *induced* loss of [MMP] and apoptosis . Negative_regulation MMP14 FAS 11980895 954082 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of [MMP] and cytochrome c release . Negative_regulation MMP14 HBEGF 17322418 1747783 Inhibition of ( HB-EGF ) release by CRM-197 and *inhibition* of [matrix metalloproteinases (MMP)] by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation . Negative_regulation MMP14 IL1B 16122880 1461086 A dose dependent inhibition of and TPA *stimulated* [MMP] activity by gallium nitrate at increasing concentrations occurs , demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis . Negative_regulation MMP14 MMP28 16940349 1609370 Importantly , the expression of also *resulted* in upregulation of [MT1-MMP] and gelatinase-B ( MMP-9 ) and in the collagen invasive activity of A549 cells . Negative_regulation MMP14 MMP28 19418307 2075844 Overall activity was augmented in both transplanted groups , but CsA *reduced* MMP-9 activity and [MMP-14] production . Negative_regulation MMP14 MMP28 9853262 554884 Matrix metalloprotease 2 (MMP2) is secreted in a latent inactive form ( pro-MMP2 ) that is activated on the cell surface by a [membrane-type 1 MMP (MT1-MMP)] in the *presence* of the tissue inhibitor of ( TIMP2 ) . Negative_regulation MMP14 MMP7 19418307 2075859 Overall activity was augmented in both transplanted groups , but CsA *reduced* MMP-9 activity and [MMP-14] production . Negative_regulation MMP14 MMP7 9853262 554899 Matrix metalloprotease 2 (MMP2) is secreted in a latent inactive form ( pro-MMP2 ) that is activated on the cell surface by a [membrane-type 1 MMP (MT1-MMP)] in the *presence* of the tissue inhibitor of ( TIMP2 ) . Negative_regulation MMP14 PLAT 22244977 2564139 We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle , delayed alone , or combined tPA ( 10 mg/kg , i.v. ) plus GM6001 ( 100 mg/kg , i.p. ) , a broad-spectrum [MMP] *inhibitor* . Negative_regulation MMP14 PLAU 12117412 997458 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Negative_regulation MMP14 PLAU 24418973 2942380 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 in the conditioned media . Negative_regulation MMP14 SPHK1 17388800 1720859 Decreasing expression by small interfering RNA ( siRNA ) , blocked IGFBP-3 induced network formation and *inhibited* VEGF , [MT1-MMP] but not IGF-I up-regulation . Negative_regulation MMP14 TFPI2 20015200 2489004 Moreover , down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in a ( 1 ) integrin on cell surface , and *increased* [MMP] expression ( mainly MMP-1 and -3 ) contributing to cancer cell invasion through basement membrane components . Negative_regulation MMP14 TNF 12506070 1038339 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in [MMP] and TIMP expression . Negative_regulation MMP14 TNF 15145598 1247702 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of [MMP] and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation MMP14 TNF 15663564 1350375 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Negative_regulation MMP14 TNF 16106101 1444995 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Negative_regulation MMP14 TNF 17469134 1737478 OSM and stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP14 TNF 19281093 2007621 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Negative_regulation MMP14 TNF 22202225 2519001 In addition , we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as ( TNF-B ) , interferon-alpha ( IFN-a ) , transforming growth factor-beta (TGF-B) , interleukins ( IL ) such as IL1-B and IL-6 , as well as [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( TIMP ) . Negative_regulation MMP14 TNFSF10 23582782 2778430 however , the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus *induced* loss of [MMP] and apoptosis . Negative_regulation MMP15 FAS 11980895 954083 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of [MMP] and cytochrome c release . Negative_regulation MMP15 HBEGF 17322418 1747784 Inhibition of heparin binding EGF-like growth factor ( ) release by CRM-197 and *inhibition* of [matrix metalloproteinases (MMP)] by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation . Negative_regulation MMP15 IL1B 16122880 1461087 A dose dependent inhibition of and TPA *stimulated* [MMP] activity by gallium nitrate at increasing concentrations occurs , demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis . Negative_regulation MMP15 PLAT 22244977 2564140 We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle , delayed tPA alone , or combined ( 10 mg/kg , i.v. ) plus GM6001 ( 100 mg/kg , i.p. ) , a broad-spectrum [MMP] *inhibitor* . Negative_regulation MMP15 PLAU 12117412 997459 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Negative_regulation MMP15 PLAU 24418973 2942381 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 in the conditioned media . Negative_regulation MMP15 TFPI2 20015200 2489005 Moreover , down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in a ( 1 ) integrin on cell surface , and *increased* [MMP] expression ( mainly MMP-1 and -3 ) contributing to cancer cell invasion through basement membrane components . Negative_regulation MMP15 TNF 12506070 1038340 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in [MMP] and TIMP expression . Negative_regulation MMP15 TNF 15145598 1247703 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of [MMP] and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation MMP15 TNF 15663564 1350376 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Negative_regulation MMP15 TNF 16106101 1444996 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Negative_regulation MMP15 TNF 17469134 1737480 OSM and stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP15 TNF 19281093 2007622 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Negative_regulation MMP15 TNF 22202225 2519002 In addition , we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as ( TNF-B ) , interferon-alpha ( IFN-a ) , transforming growth factor-beta (TGF-B) , interleukins ( IL ) such as IL1-B and IL-6 , as well as [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( TIMP ) . Negative_regulation MMP15 TNFSF10 23582782 2778431 however , the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus *induced* loss of [MMP] and apoptosis . Negative_regulation MMP16 FAS 11980895 954084 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of [MMP] and cytochrome c release . Negative_regulation MMP16 HBEGF 17322418 1747785 Inhibition of heparin binding EGF-like growth factor ( ) release by CRM-197 and *inhibition* of [matrix metalloproteinases (MMP)] by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation . Negative_regulation MMP16 IL1B 16122880 1461088 A dose dependent inhibition of and TPA *stimulated* [MMP] activity by gallium nitrate at increasing concentrations occurs , demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis . Negative_regulation MMP16 PLAT 22244977 2564141 We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle , delayed alone , or combined tPA ( 10 mg/kg , i.v. ) plus GM6001 ( 100 mg/kg , i.p. ) , a broad-spectrum [MMP] *inhibitor* . Negative_regulation MMP16 PLAU 12117412 997460 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Negative_regulation MMP16 PLAU 24418973 2942382 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 in the conditioned media . Negative_regulation MMP16 TFPI2 20015200 2489006 Moreover , down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in a ( 1 ) integrin on cell surface , and *increased* [MMP] expression ( mainly MMP-1 and -3 ) contributing to cancer cell invasion through basement membrane components . Negative_regulation MMP16 TNF 12506070 1038341 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in [MMP] and TIMP expression . Negative_regulation MMP16 TNF 15145598 1247704 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of [MMP] and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation MMP16 TNF 15663564 1350377 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Negative_regulation MMP16 TNF 16106101 1444997 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Negative_regulation MMP16 TNF 17469134 1737482 OSM and stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP16 TNF 19281093 2007623 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Negative_regulation MMP16 TNF 22202225 2519003 In addition , we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as ( TNF-B ) , interferon-alpha ( IFN-a ) , transforming growth factor-beta (TGF-B) , interleukins ( IL ) such as IL1-B and IL-6 , as well as [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( TIMP ) . Negative_regulation MMP16 TNFSF10 23582782 2778432 however , the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus *induced* loss of [MMP] and apoptosis . Negative_regulation MMP17 FAS 11980895 954085 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of [MMP] and cytochrome c release . Negative_regulation MMP17 HBEGF 17322418 1747786 Inhibition of ( HB-EGF ) release by CRM-197 and *inhibition* of [matrix metalloproteinases (MMP)] by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation . Negative_regulation MMP17 IL1B 16122880 1461089 A dose dependent inhibition of and TPA *stimulated* [MMP] activity by gallium nitrate at increasing concentrations occurs , demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis . Negative_regulation MMP17 PLAT 22244977 2564142 We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle , delayed tPA alone , or combined ( 10 mg/kg , i.v. ) plus GM6001 ( 100 mg/kg , i.p. ) , a broad-spectrum [MMP] *inhibitor* . Negative_regulation MMP17 PLAU 12117412 997461 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Negative_regulation MMP17 PLAU 24418973 2942383 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 in the conditioned media . Negative_regulation MMP17 TFPI2 20015200 2489007 Moreover , down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in a ( 1 ) integrin on cell surface , and *increased* [MMP] expression ( mainly MMP-1 and -3 ) contributing to cancer cell invasion through basement membrane components . Negative_regulation MMP17 TNF 12506070 1038342 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in [MMP] and TIMP expression . Negative_regulation MMP17 TNF 15145598 1247705 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of [MMP] and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation MMP17 TNF 15663564 1350378 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Negative_regulation MMP17 TNF 16106101 1444998 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Negative_regulation MMP17 TNF 17469134 1737484 OSM and stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP17 TNF 19281093 2007624 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Negative_regulation MMP17 TNF 22202225 2519004 In addition , we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as ( TNF-B ) , interferon-alpha ( IFN-a ) , transforming growth factor-beta (TGF-B) , interleukins ( IL ) such as IL1-B and IL-6 , as well as [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( TIMP ) . Negative_regulation MMP17 TNFSF10 23582782 2778433 however , the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus *induced* loss of [MMP] and apoptosis . Negative_regulation MMP19 FAS 11980895 954086 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of [MMP] and cytochrome c release . Negative_regulation MMP19 HBEGF 17322418 1747787 Inhibition of heparin binding EGF-like growth factor ( ) release by CRM-197 and *inhibition* of [matrix metalloproteinases (MMP)] by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation . Negative_regulation MMP19 IL1B 16122880 1461090 A dose dependent inhibition of and TPA *stimulated* [MMP] activity by gallium nitrate at increasing concentrations occurs , demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis . Negative_regulation MMP19 PLAT 22244977 2564143 We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle , delayed alone , or combined tPA ( 10 mg/kg , i.v. ) plus GM6001 ( 100 mg/kg , i.p. ) , a broad-spectrum [MMP] *inhibitor* . Negative_regulation MMP19 PLAU 12117412 997462 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Negative_regulation MMP19 PLAU 24418973 2942384 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 in the conditioned media . Negative_regulation MMP19 TFPI2 20015200 2489008 Moreover , down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in a ( 1 ) integrin on cell surface , and *increased* [MMP] expression ( mainly MMP-1 and -3 ) contributing to cancer cell invasion through basement membrane components . Negative_regulation MMP19 TNF 12506070 1038343 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in [MMP] and TIMP expression . Negative_regulation MMP19 TNF 15145598 1247706 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of [MMP] and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation MMP19 TNF 15663564 1350379 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Negative_regulation MMP19 TNF 16106101 1444999 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Negative_regulation MMP19 TNF 17469134 1737486 OSM and stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP19 TNF 19281093 2007625 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Negative_regulation MMP19 TNF 22202225 2519005 In addition , we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as ( TNF-B ) , interferon-alpha ( IFN-a ) , transforming growth factor-beta (TGF-B) , interleukins ( IL ) such as IL1-B and IL-6 , as well as [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( TIMP ) . Negative_regulation MMP19 TNFSF10 23582782 2778434 however , the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus *induced* loss of [MMP] and apoptosis . Negative_regulation MMP2 ALOX5 19586628 2194858 Thus , this study investigated the *role* of <5-LO> in HNE enhanced [MMP-2] production in VSMC , and the mechanisms by which this enzyme could be activated by HNE . Negative_regulation MMP2 CCND1 19538881 2099065 It seems to be related with down regulating the expression of and CDK4 and *inhibiting* the activity of [MMP-2] . Negative_regulation MMP2 CLU 22440257 2588396 Additionally , *inhibited* enzymatic activities of [MMP-2] , MMP-3 , and MMP-7 . Negative_regulation MMP2 EPHB2 19326946 2074122 Furthermore , the inhibitor ( U0126 ) could *result* in reduced activities of [MMP-2] and u-PA concomitantly with a marked inhibition on cell invasion and migration . Negative_regulation MMP2 EPHB2 22863019 2666072 The inhibitor blocked fluid shear stress induced MMP-1 expression and P38 inhibitor reduced fluid shear stress *stimulated* [MMP-2] expression . Negative_regulation MMP2 FAS 11980895 954087 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of [MMP] and cytochrome c release . Negative_regulation MMP2 HBEGF 17322418 1747788 Inhibition of ( HB-EGF ) release by CRM-197 and *inhibition* of [matrix metalloproteinases (MMP)] by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation . Negative_regulation MMP2 ID1 21467165 2428093 Moreover , we showed that MUC18 promotes melanoma invasion through Id-1 , as overexpression of in MUC18 silenced cells *resulted* in increased [MMP-2] expression and activity . Negative_regulation MMP2 IL1B 16122880 1461091 A dose dependent inhibition of and TPA *stimulated* [MMP] activity by gallium nitrate at increasing concentrations occurs , demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis . Negative_regulation MMP2 IL1B 16987994 1692467 activated ERK1/2 , JNKs , and protein kinase C ( PKC ) , specifically PKCalpha/beta ( 1 ) , and inhibition of these cascades partially *inhibited* IL-1beta stimulated increases in [MMP-2] . Negative_regulation MMP2 IL1B 17709570 1783233 In these cells , IL1R2 expression was markedly reduced , compared with non transfected cells or cells transfected with the empty vector , and there was a significant increase in the basal and the *induced* levels of [matrix metalloproteinase (MMP)-2] and MMP-9 secretion . Negative_regulation MMP2 IL1B 18782565 1975917 Sinomenine suppressed the production of proinflammatory cytokines and IL-6 in serum , *inhibited* the protein expressions and activities of [MMP-2] and MMP-9 , and elevated the protein expressions and activities of TIMP-1 and TIMP-3 in rat paw tissues . Negative_regulation MMP2 IL1B 19885578 2161154 TNF-alpha , , LPS and PMA , stimulated MMP-2 in LC and *inhibited* [MMP-2] in MM , but had no effect on MMP-9 . Negative_regulation MMP2 MMP28 11346466 814284 [MMP2] is *activated* by membranous type-1 MMP (MT1-MMP) and type-2 tissue inhibitor of ( TIMP2 ) . Negative_regulation MMP2 MMP28 11858950 914671 To study the *role* of in the activation of [MMP-2] , skin specimens of DF ( five cases ) and MFH ( three cases ) were immunohistochemically studied using in situ zymography and the antibodies against matrix metalloproteinase-2 (MMP-2) and membrane type 1-3-MMPs (MT1-3-MMPs) . Negative_regulation MMP2 MMP28 16046398 1459771 We previously reported that broad spectrum inhibitors like GM6001 enhance MT1-MMP dependent *activation* of [pro-MMP-2] in the presence of tissue inhibitor of metalloproteinases-2 . Negative_regulation MMP2 MMP28 16400010 1506368 Importantly , co-treatment with two different , the broad spectrum inhibitor GM6001 and an [MMP-2/9-specific] *inhibitor* , suppressed TGFbeta induced ASC changes , including the epithelial-mesenchymal transformation of lens epithelial cells . Negative_regulation MMP2 MMP28 22251575 2605723 In conclusion , non-toxic levels of alendronate ( 10 ( -8 ) to 10 ( -6 ) M ) did not alter expression in MG63 cells or *inhibit* [MMP-2] activity . Negative_regulation MMP2 MMP28 9223295 442740 Overexpression of without invadopodial localization *caused* activation of soluble [MMP-2] , but did not facilitate ECM degradation or cell invasiveness . Negative_regulation MMP2 MMP7 11346466 814299 [MMP2] is *activated* by membranous type-1 MMP (MT1-MMP) and type-2 tissue inhibitor of ( TIMP2 ) . Negative_regulation MMP2 MMP7 11858950 914686 To study the *role* of in the activation of [MMP-2] , skin specimens of DF ( five cases ) and MFH ( three cases ) were immunohistochemically studied using in situ zymography and the antibodies against matrix metalloproteinase-2 (MMP-2) and membrane type 1-3-MMPs (MT1-3-MMPs) . Negative_regulation MMP2 MMP7 16046398 1459786 We previously reported that broad spectrum inhibitors like GM6001 enhance MT1-MMP dependent *activation* of [pro-MMP-2] in the presence of tissue inhibitor of metalloproteinases-2 . Negative_regulation MMP2 MMP7 16400010 1506383 Importantly , co-treatment with two different , the broad spectrum inhibitor GM6001 and an [MMP-2/9-specific] *inhibitor* , suppressed TGFbeta induced ASC changes , including the epithelial-mesenchymal transformation of lens epithelial cells . Negative_regulation MMP2 MMP7 22251575 2605738 In conclusion , non-toxic levels of alendronate ( 10 ( -8 ) to 10 ( -6 ) M ) did not alter expression in MG63 cells or *inhibit* [MMP-2] activity . Negative_regulation MMP2 MMP7 9223295 442755 Overexpression of without invadopodial localization *caused* activation of soluble [MMP-2] , but did not facilitate ECM degradation or cell invasiveness . Negative_regulation MMP2 PECAM1 12591918 1060349 During EMT , loss of similarly *promotes* single cell motility and [MMP-2] expression . Negative_regulation MMP2 PLAT 22244977 2564144 We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle , delayed tPA alone , or combined ( 10 mg/kg , i.v. ) plus GM6001 ( 100 mg/kg , i.p. ) , a broad-spectrum [MMP] *inhibitor* . Negative_regulation MMP2 PLAU 11983447 935626 Inhibition of delays expression of c-jun , *activated* transforming growth factor beta 1 , and [matrix metalloproteinase 2] during post-hepatectomy liver regeneration in mice . Negative_regulation MMP2 PLAU 12117412 997463 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Negative_regulation MMP2 PLAU 24418973 2942385 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 in the conditioned media . Negative_regulation MMP2 TFPI2 20015200 2489009 Moreover , down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in a ( 1 ) integrin on cell surface , and *increased* [MMP] expression ( mainly MMP-1 and -3 ) contributing to cancer cell invasion through basement membrane components . Negative_regulation MMP2 TFPI2 21458846 2453523 Zymography assay showed that can *inhibit* [MMP-2] , 9 activity induced by ox-LDL . Negative_regulation MMP2 TNF 12506070 1038344 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in [MMP] and TIMP expression . Negative_regulation MMP2 TNF 14644777 1210231 To elucidate whether endogenous could *mediate* the effects of ANG II on [MMP-2] release , cells were pretreated with anti-TNF-alpha neutralizing antibodies or pentoxifylline ( an inhibitor of TNF-alpha synthesis ) . Negative_regulation MMP2 TNF 14644777 1210237 These results indicate that ANG II , via AT(1)R , modulates the secretion of TNF-alpha and MMP-2 from endothelial cells and that *mediates* the effects of ANG II on [MMP-2] release . Negative_regulation MMP2 TNF 15145598 1247707 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of [MMP] and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation MMP2 TNF 15513534 1328328 The addition of FP caused significant suppression of [MMP-2] and -9 production from nasal polyp fibroblasts in *response* to stimulation . Negative_regulation MMP2 TNF 15663564 1350380 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Negative_regulation MMP2 TNF 16106101 1445000 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Negative_regulation MMP2 TNF 16106101 1445029 TR at more than 5 x 10 ( -5 ) M inhibited the production of [MMP-2] and MMP-9 from NF in *response* to stimulation , whereas TIMP-1 and TIMP-2 production was scarcely affected . Negative_regulation MMP2 TNF 17469134 1737488 OSM and stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP2 TNF 19281093 2007626 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Negative_regulation MMP2 TNF 21518085 2423043 Transforming growth factor-ß1 suppresses the up-regulation of [matrix metalloproteinase-2] by lung fibroblasts in *response* to . Negative_regulation MMP2 TNF 21518085 2423050 We also confirmed that *induced* up-regulation of active TGF-ß1 and exogenous TGF-ß1 induced down-regulation of [MMP-2] synthesis in lung fibroblasts . Negative_regulation MMP2 TNF 22202225 2519006 In addition , we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as ( TNF-B ) , interferon-alpha ( IFN-a ) , transforming growth factor-beta (TGF-B) , interleukins ( IL ) such as IL1-B and IL-6 , as well as [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( TIMP ) . Negative_regulation MMP2 TNF 22710949 2687012 Furthermore , stimulated MMP-2 and MMP-9 activities in a dose dependent manner , but either knockdown of focal adhesion kinase ( FAK ) by short interference RNA or inhibition of extracellular regulated protein kinase ( ERK ) by chemical inhibitor could *block* TNF-a stimulated [MMP-2] and MMP-9 activities in vitro . Negative_regulation MMP2 TNF 7558248 327965 The presence of *suppresses* maturation induced transcription of [MMP-2] , enhances TIMP-1 transcription , but has little effect on MMP-9 mRNA levels . Negative_regulation MMP2 TNF 9130458 426863 This study examined the *role* of IFN-gamma and ( + ) in the regulation of the matrix metalloproteinases , [MMP-2] ( 72 kD gelatinase A ) and MMP-9 ( 92 kD gelatinase B ) . Negative_regulation MMP2 TNF 9862695 556045 Furthermore , *inhibition* of [MMP-2] expression results in decreased invasiveness of the human astroglioma cells through an extracellular matrix . Negative_regulation MMP2 TNFSF10 16622457 1556731 Moreover , the expression of [MMP-2] , its inhibitor TIMP-2 and the tumour invasiveness related protein SPARC were effectively *inhibited* by in glioblastoma cell lines . Negative_regulation MMP2 TNFSF10 23582782 2778435 however , the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus *induced* loss of [MMP] and apoptosis . Negative_regulation MMP20 FAS 11980895 954088 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of [MMP] and cytochrome c release . Negative_regulation MMP20 HBEGF 17322418 1747789 Inhibition of heparin binding EGF-like growth factor ( ) release by CRM-197 and *inhibition* of [matrix metalloproteinases (MMP)] by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation . Negative_regulation MMP20 IL1B 16122880 1461092 A dose dependent inhibition of and TPA *stimulated* [MMP] activity by gallium nitrate at increasing concentrations occurs , demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis . Negative_regulation MMP20 PLAT 22244977 2564145 We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle , delayed alone , or combined tPA ( 10 mg/kg , i.v. ) plus GM6001 ( 100 mg/kg , i.p. ) , a broad-spectrum [MMP] *inhibitor* . Negative_regulation MMP20 PLAU 12117412 997464 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Negative_regulation MMP20 PLAU 24418973 2942386 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 in the conditioned media . Negative_regulation MMP20 TFPI2 20015200 2489010 Moreover , down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in a ( 1 ) integrin on cell surface , and *increased* [MMP] expression ( mainly MMP-1 and -3 ) contributing to cancer cell invasion through basement membrane components . Negative_regulation MMP20 TNF 12506070 1038345 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in [MMP] and TIMP expression . Negative_regulation MMP20 TNF 15145598 1247708 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of [MMP] and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation MMP20 TNF 15663564 1350381 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Negative_regulation MMP20 TNF 16106101 1445001 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Negative_regulation MMP20 TNF 17469134 1737490 OSM and stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP20 TNF 19281093 2007627 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Negative_regulation MMP20 TNF 22202225 2519007 In addition , we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as ( TNF-B ) , interferon-alpha ( IFN-a ) , transforming growth factor-beta (TGF-B) , interleukins ( IL ) such as IL1-B and IL-6 , as well as [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( TIMP ) . Negative_regulation MMP20 TNFSF10 23582782 2778436 however , the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus *induced* loss of [MMP] and apoptosis . Negative_regulation MMP21 FAS 11980895 954074 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of [MMP] and cytochrome c release . Negative_regulation MMP21 HBEGF 17322418 1747776 Inhibition of ( HB-EGF ) release by CRM-197 and *inhibition* of [matrix metalloproteinases (MMP)] by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation . Negative_regulation MMP21 IL1B 16122880 1461079 A dose dependent inhibition of and TPA *stimulated* [MMP] activity by gallium nitrate at increasing concentrations occurs , demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis . Negative_regulation MMP21 PLAT 22244977 2564132 We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle , delayed tPA alone , or combined ( 10 mg/kg , i.v. ) plus GM6001 ( 100 mg/kg , i.p. ) , a broad-spectrum [MMP] *inhibitor* . Negative_regulation MMP21 PLAU 12117412 997451 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Negative_regulation MMP21 PLAU 24418973 2942373 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 in the conditioned media . Negative_regulation MMP21 TFPI2 20015200 2488997 Moreover , down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in a ( 1 ) integrin on cell surface , and *increased* [MMP] expression ( mainly MMP-1 and -3 ) contributing to cancer cell invasion through basement membrane components . Negative_regulation MMP21 TNF 12506070 1038332 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in [MMP] and TIMP expression . Negative_regulation MMP21 TNF 15145598 1247694 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of [MMP] and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation MMP21 TNF 15663564 1350368 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Negative_regulation MMP21 TNF 16106101 1444988 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Negative_regulation MMP21 TNF 17469134 1737464 OSM and stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP21 TNF 19281093 2007614 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Negative_regulation MMP21 TNF 22202225 2518994 In addition , we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as ( TNF-B ) , interferon-alpha ( IFN-a ) , transforming growth factor-beta (TGF-B) , interleukins ( IL ) such as IL1-B and IL-6 , as well as [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( TIMP ) . Negative_regulation MMP21 TNFSF10 23582782 2778423 however , the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus *induced* loss of [MMP] and apoptosis . Negative_regulation MMP24 FAS 11980895 954089 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of [MMP] and cytochrome c release . Negative_regulation MMP24 HBEGF 17322418 1747790 Inhibition of ( HB-EGF ) release by CRM-197 and *inhibition* of [matrix metalloproteinases (MMP)] by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation . Negative_regulation MMP24 IL1B 16122880 1461093 A dose dependent inhibition of and TPA *stimulated* [MMP] activity by gallium nitrate at increasing concentrations occurs , demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis . Negative_regulation MMP24 PLAT 22244977 2564146 We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle , delayed alone , or combined tPA ( 10 mg/kg , i.v. ) plus GM6001 ( 100 mg/kg , i.p. ) , a broad-spectrum [MMP] *inhibitor* . Negative_regulation MMP24 PLAU 12117412 997465 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Negative_regulation MMP24 PLAU 24418973 2942387 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 in the conditioned media . Negative_regulation MMP24 TFPI2 20015200 2489011 Moreover , down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in a ( 1 ) integrin on cell surface , and *increased* [MMP] expression ( mainly MMP-1 and -3 ) contributing to cancer cell invasion through basement membrane components . Negative_regulation MMP24 TNF 12506070 1038346 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in [MMP] and TIMP expression . Negative_regulation MMP24 TNF 15145598 1247709 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of [MMP] and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation MMP24 TNF 15663564 1350382 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Negative_regulation MMP24 TNF 16106101 1445002 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Negative_regulation MMP24 TNF 17469134 1737492 OSM and stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP24 TNF 19281093 2007628 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Negative_regulation MMP24 TNF 22202225 2519008 In addition , we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as ( TNF-B ) , interferon-alpha ( IFN-a ) , transforming growth factor-beta (TGF-B) , interleukins ( IL ) such as IL1-B and IL-6 , as well as [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( TIMP ) . Negative_regulation MMP24 TNFSF10 23582782 2778437 however , the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus *induced* loss of [MMP] and apoptosis . Negative_regulation MMP25 FAS 11980895 954071 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of [MMP] and cytochrome c release . Negative_regulation MMP25 HBEGF 17322418 1747773 Inhibition of ( HB-EGF ) release by CRM-197 and *inhibition* of [matrix metalloproteinases (MMP)] by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation . Negative_regulation MMP25 IL1B 16122880 1461076 A dose dependent inhibition of and TPA *stimulated* [MMP] activity by gallium nitrate at increasing concentrations occurs , demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis . Negative_regulation MMP25 PLAT 22244977 2564129 We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle , delayed tPA alone , or combined ( 10 mg/kg , i.v. ) plus GM6001 ( 100 mg/kg , i.p. ) , a broad-spectrum [MMP] *inhibitor* . Negative_regulation MMP25 PLAU 12117412 997448 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Negative_regulation MMP25 PLAU 24418973 2942370 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 in the conditioned media . Negative_regulation MMP25 TFPI2 20015200 2488994 Moreover , down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in a ( 1 ) integrin on cell surface , and *increased* [MMP] expression ( mainly MMP-1 and -3 ) contributing to cancer cell invasion through basement membrane components . Negative_regulation MMP25 TNF 12506070 1038329 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in [MMP] and TIMP expression . Negative_regulation MMP25 TNF 15145598 1247691 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of [MMP] and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation MMP25 TNF 15663564 1350365 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Negative_regulation MMP25 TNF 16106101 1444985 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Negative_regulation MMP25 TNF 17469134 1737458 OSM and stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP25 TNF 19281093 2007611 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Negative_regulation MMP25 TNF 22202225 2518991 In addition , we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as ( TNF-B ) , interferon-alpha ( IFN-a ) , transforming growth factor-beta (TGF-B) , interleukins ( IL ) such as IL1-B and IL-6 , as well as [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( TIMP ) . Negative_regulation MMP25 TNFSF10 23582782 2778420 however , the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus *induced* loss of [MMP] and apoptosis . Negative_regulation MMP26 FAS 11980895 954072 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of [MMP] and cytochrome c release . Negative_regulation MMP26 HBEGF 17322418 1747774 Inhibition of heparin binding EGF-like growth factor ( ) release by CRM-197 and *inhibition* of [matrix metalloproteinases (MMP)] by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation . Negative_regulation MMP26 IL1B 16122880 1461077 A dose dependent inhibition of and TPA *stimulated* [MMP] activity by gallium nitrate at increasing concentrations occurs , demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis . Negative_regulation MMP26 PLAT 22244977 2564130 We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle , delayed alone , or combined tPA ( 10 mg/kg , i.v. ) plus GM6001 ( 100 mg/kg , i.p. ) , a broad-spectrum [MMP] *inhibitor* . Negative_regulation MMP26 PLAU 12117412 997449 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Negative_regulation MMP26 PLAU 24418973 2942371 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 in the conditioned media . Negative_regulation MMP26 TFPI2 20015200 2488995 Moreover , down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in a ( 1 ) integrin on cell surface , and *increased* [MMP] expression ( mainly MMP-1 and -3 ) contributing to cancer cell invasion through basement membrane components . Negative_regulation MMP26 TNF 12506070 1038330 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in [MMP] and TIMP expression . Negative_regulation MMP26 TNF 15145598 1247692 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of [MMP] and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation MMP26 TNF 15663564 1350366 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Negative_regulation MMP26 TNF 16106101 1444986 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Negative_regulation MMP26 TNF 17469134 1737460 OSM and stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP26 TNF 19281093 2007612 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Negative_regulation MMP26 TNF 22202225 2518992 In addition , we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as ( TNF-B ) , interferon-alpha ( IFN-a ) , transforming growth factor-beta (TGF-B) , interleukins ( IL ) such as IL1-B and IL-6 , as well as [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( TIMP ) . Negative_regulation MMP26 TNFSF10 23582782 2778421 however , the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus *induced* loss of [MMP] and apoptosis . Negative_regulation MMP27 FAS 11980895 954073 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of [MMP] and cytochrome c release . Negative_regulation MMP27 HBEGF 17322418 1747775 Inhibition of ( HB-EGF ) release by CRM-197 and *inhibition* of [matrix metalloproteinases (MMP)] by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation . Negative_regulation MMP27 IL1B 16122880 1461078 A dose dependent inhibition of and TPA *stimulated* [MMP] activity by gallium nitrate at increasing concentrations occurs , demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis . Negative_regulation MMP27 PLAT 22244977 2564131 We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle , delayed tPA alone , or combined ( 10 mg/kg , i.v. ) plus GM6001 ( 100 mg/kg , i.p. ) , a broad-spectrum [MMP] *inhibitor* . Negative_regulation MMP27 PLAU 12117412 997450 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Negative_regulation MMP27 PLAU 24418973 2942372 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 in the conditioned media . Negative_regulation MMP27 TFPI2 20015200 2488996 Moreover , down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in a ( 1 ) integrin on cell surface , and *increased* [MMP] expression ( mainly MMP-1 and -3 ) contributing to cancer cell invasion through basement membrane components . Negative_regulation MMP27 TNF 12506070 1038331 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in [MMP] and TIMP expression . Negative_regulation MMP27 TNF 15145598 1247693 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of [MMP] and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation MMP27 TNF 15663564 1350367 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Negative_regulation MMP27 TNF 16106101 1444987 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Negative_regulation MMP27 TNF 17469134 1737462 OSM and stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP27 TNF 19281093 2007613 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Negative_regulation MMP27 TNF 22202225 2518993 In addition , we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as ( TNF-B ) , interferon-alpha ( IFN-a ) , transforming growth factor-beta (TGF-B) , interleukins ( IL ) such as IL1-B and IL-6 , as well as [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( TIMP ) . Negative_regulation MMP27 TNFSF10 23582782 2778422 however , the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus *induced* loss of [MMP] and apoptosis . Negative_regulation MMP28 A2M 12860260 1111203 Circulating levels of MMPs and TIMPs were associated neither with those of C-reactive protein , nor with those of ( a nonspecific [MMP] *inhibitor* ) , nor with intima-media thickness values . Negative_regulation MMP28 ACAN 23797671 2815506 Exposure of the explants to recombinant hTryptase-ß , recombinant mMCP-6 , or lysates harvested from WT mouse peritoneal MCs ( PMCs ) significantly increased the levels of enzymatically active [matrix metalloproteinases (MMP)] in cartilage and significantly *induced* loss into the conditioned media , relative to replicate explants exposed to medium alone or lysates collected from mMCP-6-null PMCs . Negative_regulation MMP28 ACE 10525103 653910 This study examined the effects of specific [MMP] inhibition , *inhibition* , and combined treatment on LV systolic and diastolic function in a model of CHF . Negative_regulation MMP28 ACE 17308006 1747453 This study sought to determine whether inhibitors can directly *regulate* [MMP] activity and whether this results in positive structural and functional adaptations to the heart . Negative_regulation MMP28 AKT1 16142341 1451109 Inhibition of signaling in LM8 by a PI3K inhibitor , LY294002 , or by a dominant negative form of Akt , *resulted* in suppression of [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Negative_regulation MMP28 AKT2 16142341 1451110 Inhibition of signaling in LM8 by a PI3K inhibitor , LY294002 , or by a dominant negative form of Akt , *resulted* in suppression of [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Negative_regulation MMP28 AKT3 16142341 1451111 Inhibition of signaling in LM8 by a PI3K inhibitor , LY294002 , or by a dominant negative form of Akt , *resulted* in suppression of [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Negative_regulation MMP28 APAF1 22226830 2550029 Altogether , we have for the first time demonstrated the critical *role* of in the regulation of MAPK , ROS , and [MMP] in UVC radiated MEFs and propose that the amplification feedback loop among mitochondrial signal molecules culminates in the demise of the cell . Negative_regulation MMP28 ARG1 15584904 1345397 Both a pseudosubstrate furin inhibitor , ( dec-RVKR-cmk ) , or alpha 1-anti-trypsin Portland ( PDX ) , a recombinant furin-inhibitory protein , *suppress* constitutive and BCL-2 mediated [MMP] activity and invasion . Negative_regulation MMP28 ARG2 15584904 1345398 Both a pseudosubstrate furin inhibitor , ( dec-RVKR-cmk ) , or alpha 1-anti-trypsin Portland ( PDX ) , a recombinant furin-inhibitory protein , *suppress* constitutive and BCL-2 mediated [MMP] activity and invasion . Negative_regulation MMP28 BAX 19513559 2092515 The WEPN treatment *induced* the upregulation of pro-apoptotic , downregulation of anti-apoptotic Bcl-2 expression and loss of mitochondrial [membrane potential (MMP)] , which was associated with the proteolytic activation of caspases and the concomitant degradation of poly ( ADP ribose ) polymerase ( PARP ) protein . Negative_regulation MMP28 BAX 22419111 2572713 Pharmacologic inhibitors of the permeability transition pore , inhibitors , and recombinant Bcl-2 and Bcl-XL proteins do not *reduce* Tat induced [MMP] . Negative_regulation MMP28 BCL2 17955488 1844585 Overexpression of in HN4 cells *prevented* loss of [MMP] , nuclear translocation of EndoG and protected cells from the delayed apoptosis induced by cisplatin in the presence of z-VAD-fmk . Negative_regulation MMP28 BCL2 23437193 2744525 Increased of reactive oxygen species ( ROS ) production , coupled with downregulation of anti-apoptotic molecules ( , Bcl-xL ) *led* to reduction of mitochondrial [membrane potential (MMP)] and release of cytochrome c in both human breast cancer cells treated with vernodalin . Negative_regulation MMP28 BNIP3 22292033 2545662 Although the overexpression of either or NIX did not *cause* a remarkable change in the mitochondrial [membrane potential (MMP)] , the co-expression of all three exogenous proteins , Mieap , BNIP3 and NIX , caused a dramatic reduction in MMP , implying that the physical interaction of Mieap , BNIP3 and NIX at the mitochondrial outer membrane may regulate the opening of a pore in the mitochondrial double membrane . Negative_regulation MMP28 BSG 16207318 1464226 The *role* of in [MMP] production and cell invasion in vitro were studied through the co-culture of human CD14+ monocytes or monocytic line THP-1 cells and human fibroblasts , as well as by gel zymography and an invasion assay . Negative_regulation MMP28 BSG 16507143 1574145 The *role* of in [MMP] production and the cells ' invasiveness in vitro were studied by the co-culture of FLS with the human THP-1 cell line or monocytes/macrophages , by gel zymography and by invasion assay . Negative_regulation MMP28 BSG 17869266 1843136 Expression of mutant *inhibited* the betaAR stimulated increases in MMP2 expression and zymographic [MMP] activity . Negative_regulation MMP28 BSG 18281245 1885213 The expression of extracellular matrix metalloproteinase inducer ( ) , matrix metalloproteinases ( MMPs ) , tissue *inhibitors* of [MMP] ( TIMPs ) and collagens were assessed by western blot analysis . Negative_regulation MMP28 BSG 19003972 2016223 We have analysed the *role* of in the induction of [MMP] genes during mammary gland differentiation and involution . Negative_regulation MMP28 BSG 20369361 2238534 The current results indicate that could thus be *involved* in the early stage of tooth germ development and morphogenesis , possibly by regulating the expression of [MMP] genes . Negative_regulation MMP28 CA2 18661233 2028091 Baicalein *induced* an increase in the cytoplasmic levels of ROS and in 1 h and reached their peak at 3 h , and thereafter a loss of [MMP] by flow cytometry . Negative_regulation MMP28 CD2 16458199 1522473 ( 25 microM ) *reduced* the mitochondrial [membrane potential (MMP)] as measured by flow cytometry . Negative_regulation MMP28 CD34 21122408 2355515 Circulating endothelial cells ( CECs ) were detected by flowcytometry , and the expression of matrix metalloproteinase ( MMP-2 , MMP-9 ) , the tissue *inhibitor* of [MMP] ( TIMP-1 , TIMP-2 ) , the extracellular MMP inducer ( EMMPRIN ) , , a-smooth muscle actin ( a-SMA ) were determined by immunohistochemistry . Negative_regulation MMP28 CD40 20921282 2337484 Furthermore , *induced* the IFN-?- and NO-dependent decrease in [matrix metalloproteinase (MMP)] expression and activity , concomitant with increases in tissue inhibitor of metalloproteinase ( TIMP ) 1 and E-cadherin expression within tumors . Negative_regulation MMP28 CDC73 23911909 2840204 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Negative_regulation MMP28 CDH1 12875984 1115247 *mediates* [MMP] down-regulation in highly invasive bronchial tumor cells . Negative_regulation MMP28 CORT 11930228 894572 The disruption of [MMP] was *induced* by ( 10 ( 6 ) mol/L ) in hippocampal neurons cultured in hypoglycemic and serum free medium and antagonized by high concentration of glucose . Negative_regulation MMP28 CORT 11930228 894616 *induced* reduction of [MMP] may be one of the mechanisms for its neurotoxicity . Negative_regulation MMP28 CPZ 23368734 2739051 This study identified cytotoxicity and *inhibition* of mitochondrial [membrane potential (MMP)] to be concentration dependent . Negative_regulation MMP28 CRIP1 17714826 1816895 It has been reported that an endogenous [matrix metalloproteinase (MMP)] inhibitor , reversion *inducing* with Kazal motifs ( RECK ) , is able to inhibit tumour angiogenesis , invasion , and metastasis through inhibition of MMP-2 , MMP-9 , and membrane type-1 (MT1)-MMP ( MMP-14 ) secretion and activity . Negative_regulation MMP28 CRIP1 24812324 2944784 Mechanistically , miR-712 stimulated MMP activity in the aortic wall by directly targeting 2 [MMP] inhibitors : tissue inhibitor of metalloproteinase 3 ( TIMP3 ) and reversion *inducing* with kazal motifs ( RECK ) . Negative_regulation MMP28 CRIP2 17714826 1816896 It has been reported that an endogenous [matrix metalloproteinase (MMP)] inhibitor , reversion *inducing* with Kazal motifs ( RECK ) , is able to inhibit tumour angiogenesis , invasion , and metastasis through inhibition of MMP-2 , MMP-9 , and membrane type-1 (MT1)-MMP ( MMP-14 ) secretion and activity . Negative_regulation MMP28 CRIP2 24812324 2944785 Mechanistically , miR-712 stimulated MMP activity in the aortic wall by directly targeting 2 [MMP] inhibitors : tissue inhibitor of metalloproteinase 3 ( TIMP3 ) and reversion *inducing* with kazal motifs ( RECK ) . Negative_regulation MMP28 CRIP3 17714826 1816894 It has been reported that an endogenous [matrix metalloproteinase (MMP)] inhibitor , reversion *inducing* with Kazal motifs ( RECK ) , is able to inhibit tumour angiogenesis , invasion , and metastasis through inhibition of MMP-2 , MMP-9 , and membrane type-1 (MT1)-MMP ( MMP-14 ) secretion and activity . Negative_regulation MMP28 CRIP3 24812324 2944783 Mechanistically , miR-712 stimulated MMP activity in the aortic wall by directly targeting 2 [MMP] inhibitors : tissue inhibitor of metalloproteinase 3 ( TIMP3 ) and reversion *inducing* with kazal motifs ( RECK ) . Negative_regulation MMP28 CTR9 23911909 2840205 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Negative_regulation MMP28 CXCL9 11304581 803733 Migration on Ln-5 is blocked by BB-94 , an [MMP] *inhibitor* , and by , a monoclonal antibody that hinders migration on MMP-2 cleaved Ln-5 . Negative_regulation MMP28 CYBB 24624929 2934192 Increased cardiomyocyte hypertrophy and myocardial fibrosis in response to pressure overload correlated with increased oxidative stress , and loss of prevented the increase in oxidative stress , development of cardiomyocyte hypertrophy , myocardial fibrosis and *increased* myocardial [MMP] ( matrix metalloproteinase ) activity in response to pressure overload . Negative_regulation MMP28 CYCS 11067917 747088 Overexpression of B cell lymphoma gene 2 (Bcl-2) *inhibited* TRAIL induced release of , changes in [MMP] , and apoptosis . Negative_regulation MMP28 ECE1 16323056 1487996 The mRNA levels of preproET-1 , endothelin converting enzyme ( ) , ETa receptor and ETb receptor , matrix metalloproteinase ( MMP-2 ) , tissue *inhibitor* of [MMP] ( TIMP-2 ) , and heat shock protein ( HSP-70 ) were determined by quantitative real-time RT-PCR . Negative_regulation MMP28 ELANE 18492178 1497371 inhibition of activity to *prevent* extracellular matrix damage and activation of matrix metalloproteases ( MMPs ) , and inhibition of [MMP] expression ( e.g. by retinoids ) and activity ( e.g. by natural and synthetic inhibitors ) . Negative_regulation MMP28 ERBB2 18851945 1988653 The expression of [matrix metalloproteinase (MMP)] genes was *enhanced* by the overexpression of . Negative_regulation MMP28 ERBB2 19457660 2090857 Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent [MMP] selectivity and sheddase *inhibition* . Negative_regulation MMP28 ETS1 18851945 1988654 The expression of [matrix metalloproteinase (MMP)] genes was *enhanced* by the overexpression of . Negative_regulation MMP28 FAS 11980895 954075 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of [MMP] and cytochrome c release . Negative_regulation MMP28 FGF2 15363819 1293988 Augmented levels may *contribute* to parallel decreases in [MMP] activity and MMP induction system resulting in enhanced collagen deposition in hypertension . Negative_regulation MMP28 GP2 19208844 2039304 RECK , a glycosylphosphatidylinositol anchored , *inhibits* the enzymatic activities of some [matrix metalloproteinases (MMP)] , thereby suppressing tumor cell metastasis ; Negative_regulation MMP28 GP5 19208844 2039305 RECK , a glycosylphosphatidylinositol anchored , *inhibits* the enzymatic activities of some [matrix metalloproteinases (MMP)] , thereby suppressing tumor cell metastasis ; Negative_regulation MMP28 GP6 19208844 2039303 RECK , a glycosylphosphatidylinositol anchored , *inhibits* the enzymatic activities of some [matrix metalloproteinases (MMP)] , thereby suppressing tumor cell metastasis ; Negative_regulation MMP28 GP9 19208844 2039306 RECK , a glycosylphosphatidylinositol anchored , *inhibits* the enzymatic activities of some [matrix metalloproteinases (MMP)] , thereby suppressing tumor cell metastasis ; Negative_regulation MMP28 HAND2 20627079 2291840 Loss of function *causes* reduced [MMP] activity and prolonged laminin deposition at the LPM/gut boundary , leading to failed asymmetric LPM migration and gut looping . Negative_regulation MMP28 HBEGF 17322418 1747777 Inhibition of heparin binding EGF-like growth factor ( ) release by CRM-197 and *inhibition* of [matrix metalloproteinases (MMP)] by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation . Negative_regulation MMP28 HDAC1 20144149 2236016 The present study demonstrates that [MMP28] expression is *induced* by ( histone deacetylase ) inhibitors and that this effect is mediated through the GT-box . Negative_regulation MMP28 HDAC2 20144149 2236017 The present study demonstrates that [MMP28] expression is *induced* by ( histone deacetylase ) inhibitors and that this effect is mediated through the GT-box . Negative_regulation MMP28 HDAC4 20847282 2325704 Furthermore , ectopic expression of in quiescent HSCs *results* in repression of [MMP] promoter activities as well as endogenous MMP9 protein expression . Negative_regulation MMP28 HPR 21723035 2460976 TMEM14A prevented <4-HPR> *induced* loss of mitochondrial [membrane potential (MMP)] , the release of cytochrome c , and the activation of caspase-3 , but not the generation of reactive oxygen species , suggesting that TMEM14A regulates mitochondrial membrane potential in a ROS independent manner . Negative_regulation MMP28 HPR 21723035 2461070 As expected , cyclosporin A , an inhibitor of membrane potential transition , inhibited <4-HPR> *induced* loss of [MMP] and apoptosis in U87MG cells , indicating that loss of MMP plays a pivotal role in 4-HPR induced apoptosis . Negative_regulation MMP28 IFNG 18802113 1964613 , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly *suppressed* TLR induced [MMP] expression . Negative_regulation MMP28 IL10 9561025 477851 However may *inhibit* the production of [matrix metalloproteases (MMP)] and prevent the establishment of metastasis . Negative_regulation MMP28 IL1A 18975039 2059494 In the *presence* of , the broad-spectrum MMP inhibitor GM 6001 decreased the [MMP] activity in the media , increased the shear strength of repair , and enhanced tissue repair in the interface . Negative_regulation MMP28 IL1A 22415590 2686468 Stimulation of cells with only *resulted* in an overexpression of [MMP] and their TIMP mRNAs . Negative_regulation MMP28 IL1B 16122880 1461080 A dose dependent inhibition of and TPA *stimulated* [MMP] activity by gallium nitrate at increasing concentrations occurs , demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis . Negative_regulation MMP28 IL2 20921282 2337485 Furthermore , *induced* the IFN-?- and NO-dependent decrease in [matrix metalloproteinase (MMP)] expression and activity , concomitant with increases in tissue inhibitor of metalloproteinase ( TIMP ) 1 and E-cadherin expression within tumors . Negative_regulation MMP28 IL21R 16682426 1645813 IBD LPMC supernatants stimulate [MMP] secretion by intestinal fibroblasts , and this effect is partly *inhibited* by . Negative_regulation MMP28 IL6 8515078 222001 The results suggest that OM as well as and LIF , other cytokines acting through similar receptor pathways , may act to *inhibit* net [MMP] activity by specifically up-regulating TIMP-1 expression . Negative_regulation MMP28 ISL1 19157825 2182275 dose-dependently *suppressed* PMA induced expression and activity of MMP-2 and membrane type [1-MMP] at > or=1 microM while diminishing the elevated MMP-2 transcript level . Negative_regulation MMP28 ISL1 19157825 2182324 Therefore , the *inhibition* of [MMP] may boost a therapeutic efficacy during angiogenesis . Negative_regulation MMP28 ISL2 19157825 2182274 dose-dependently *suppressed* PMA induced expression and activity of MMP-2 and membrane type [1-MMP] at > or=1 microM while diminishing the elevated MMP-2 transcript level . Negative_regulation MMP28 ISL2 19157825 2182323 Therefore , the *inhibition* of [MMP] may boost a therapeutic efficacy during angiogenesis . Negative_regulation MMP28 LCN1 8922288 396973 When the complex *inhibits* an [MMP] , a quaternary complex monomer/lipocalin/TIMP-1/MMP is generated which after activation shows a sixfold higher proteolytic activity than the active ternary complex . Negative_regulation MMP28 LCN10 8922288 396969 When the complex *inhibits* an [MMP] , a quaternary complex monomer/lipocalin/TIMP-1/MMP is generated which after activation shows a sixfold higher proteolytic activity than the active ternary complex . Negative_regulation MMP28 LCN12 8922288 396971 When the complex *inhibits* an [MMP] , a quaternary complex monomer/lipocalin/TIMP-1/MMP is generated which after activation shows a sixfold higher proteolytic activity than the active ternary complex . Negative_regulation MMP28 LCN15 8922288 396972 When the complex *inhibits* an [MMP] , a quaternary complex monomer/lipocalin/TIMP-1/MMP is generated which after activation shows a sixfold higher proteolytic activity than the active ternary complex . Negative_regulation MMP28 LCN2 8922288 396974 When the complex *inhibits* an [MMP] , a quaternary complex monomer/lipocalin/TIMP-1/MMP is generated which after activation shows a sixfold higher proteolytic activity than the active ternary complex . Negative_regulation MMP28 LCN6 8922288 396967 When the complex *inhibits* an [MMP] , a quaternary complex monomer/lipocalin/TIMP-1/MMP is generated which after activation shows a sixfold higher proteolytic activity than the active ternary complex . Negative_regulation MMP28 LCN8 8922288 396970 When the complex *inhibits* an [MMP] , a quaternary complex monomer/lipocalin/TIMP-1/MMP is generated which after activation shows a sixfold higher proteolytic activity than the active ternary complex . Negative_regulation MMP28 LCN9 8922288 396968 When the complex *inhibits* an [MMP] , a quaternary complex monomer/lipocalin/TIMP-1/MMP is generated which after activation shows a sixfold higher proteolytic activity than the active ternary complex . Negative_regulation MMP28 LEO1 23911909 2840208 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Negative_regulation MMP28 LIF 8515078 222002 The results suggest that OM as well as IL-6 and , other cytokines acting through similar receptor pathways , may act to *inhibit* net [MMP] activity by specifically up-regulating TIMP-1 expression . Negative_regulation MMP28 LMNA 16764831 1585487 [MMP] was hyperpolarized after 30OGD ( 1.26 +/- 0.23 ( vehicle ) , 1.29 +/- 0.13 ( Pro0.1 ) and 1.18 +/- 0.06 ( Pro1.0 ) ) but was depolarized after 90OGD ( 0.77 +/- 0.04 ( vehicle ) , 0.89 +/- 0.04 ( Pro0.1 ) , but .0 *prevented* depolarization ( 1.03 +/- 0.15 ( P < 0.05 ) ) . Negative_regulation MMP28 MAP3K7 23962703 2909498 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , mitogen activated protein kinases (MAPK) : mitogen activated protein kinase kinase kinase 7 ( ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP28 MAPK1 23962703 2909499 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP28 MAPK10 23962703 2909500 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP28 MAPK11 23962703 2909501 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP28 MAPK12 23962703 2909502 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP28 MAPK13 23962703 2909503 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP28 MAPK14 23962703 2909504 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP28 MAPK15 23962703 2909497 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP28 MAPK3 23962703 2909505 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP28 MAPK4 23962703 2909506 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP28 MAPK6 23962703 2909507 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP28 MAPK7 23962703 2909508 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP28 MAPK8 23962703 2909509 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP28 MAPK9 23962703 2909510 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP28 MIF 16872482 1663436 In the present study , we determined the *role* of in RA synovial fibroblast [MMP] production and the underlying signaling mechanisms . Negative_regulation MMP28 MMP1 11522015 852628 The concentrations of t-PA , PAI-1 , collagenase ( ) , tissue *inhibitor* of [MMP] ( TIMP-1 ) , plasmin-antiplasmin (PAP) complexes and alpha2-macroglobulin (alpha2-M) were measured in plasma samples . Negative_regulation MMP28 MMP1 11730752 884970 To assess the presence of matrix metalloproteinase ( ) and tissue *inhibitor* of [MMP] ( TIMP-1 ) in peritoneal fluid and serum of subjects with and without adhesions . Negative_regulation MMP28 MMP1 11817102 887987 In conclusion , these findings suggest that the activity of MMPs may bealtered by downregulation and *inhibition* of [MMP] activity by PAl-1 and TIMP-1 generated from tubular epithelial cells . Negative_regulation MMP28 MMP12 19513084 2128539 To assess the functions of MMPs in flow induced outward vascular remodeling , we used doxycycline ( broad-spectrum [MMP] *inhibitor* ) , SB-3CT ( selective MMP inhibitor ) , MMP-9 knockout mice , and knockout mice . Negative_regulation MMP28 MMP13 10415735 631348 We studied AG3340 , a potent metalloproteinase ( [MMP] ) *inhibitor* with pM affinities for inhibiting gelatinases ( MMP-2 and -9 ) , MT-MMP-1 ( MMP-14 ) , and collagenase-3 ( ) in many tumor models . Negative_regulation MMP28 MMP13 10537164 563057 In this study , we have examined the physiological regulation pattern and cellular distribution of messenger RNAs coding for gelatinase A ( MMP-2 ) , collagenase-3 ( ) , membrane type MMP 1 ( MT1-MMP , MMP-14 ) , and the major [MMP] *inhibitor* , tissue inhibitor of MMPs type 1 (TIMP-1) in the CL of adult pseudopregnant (psp) rat . Negative_regulation MMP28 MMP14 10415735 631349 We studied AG3340 , a potent metalloproteinase ( [MMP] ) *inhibitor* with pM affinities for inhibiting gelatinases ( MMP-2 and -9 ) , MT-MMP-1 ( ) , and collagenase-3 ( MMP-13 ) in many tumor models . Negative_regulation MMP28 MMP14 20000122 2174790 The aim of this study was to elucidate peculiarity of expression of gelatinases A and B ( MMP-2 and MMP-9 ) , membrane type MMP ( ) and tissue *inhibitor* of [MMP] ( TIMP-2 ) in immortal ( IF ) and transformed fibroblasts ( TF ) . Negative_regulation MMP28 MMP16 11891989 920533 We cloned two new Xenopus MMPs , gelatinase A ( MMP-2 ) and MT3-MMP ( ) , and the [MMP] *inhibitor* TIMP-2 . Negative_regulation MMP28 MMP17 24098510 2852258 Morpholino inactivation of function , or chemical *inhibition* of [MMP] activity results in aberrant NC cell migration with minimal change in NC proliferation or apoptosis . Negative_regulation MMP28 MMP2 10537164 563058 In this study , we have examined the physiological regulation pattern and cellular distribution of messenger RNAs coding for gelatinase A ( ) , collagenase-3 ( MMP-13 ) , membrane type MMP 1 ( MT1-MMP , MMP-14 ) , and the major [MMP] *inhibitor* , tissue inhibitor of MMPs type 1 (TIMP-1) in the CL of adult pseudopregnant (psp) rat . Negative_regulation MMP28 MMP2 11891989 920534 We cloned two new Xenopus MMPs , gelatinase A ( ) and MT3-MMP ( MMP-16 ) , and the [MMP] *inhibitor* TIMP-2 . Negative_regulation MMP28 MMP2 17604018 1779654 Treatment with bafilomycin A1 , an activator , or GM6001 , an [MMP] *inhibitor* , at the pre-condensation stage resulted in the inhibition or promotion of chondrogenesis , respectively . Negative_regulation MMP28 MMP2 22042083 2540077 This effect may be partially mediated by increased and TIMP activities in the aortic wall and *reduced* TNFa stimulated inflammation and [MMP] activation in macrophages . Negative_regulation MMP28 MMP2 22251575 2605708 In conclusion , non-toxic levels of alendronate ( 10 ( -8 ) to 10 ( -6 ) M ) did not alter [MMP] expression in MG63 cells or *inhibit* activity . Negative_regulation MMP28 MMP9 22742512 2691612 We also investigated the capacity of these compounds to reduce cytokine and [matrix metalloproteinase (MMP)] secretion by lipopolysaccharide (LPS) stimulated macrophages and to *inhibit* activity . Negative_regulation MMP28 MTOR 22449440 2582952 Furthermore , it was found that *caused* a loss of mitochondrial [membrane potential (MMP)] and the release of cytochrome c to the cytosol . Negative_regulation MMP28 NA 13677383 1140069 We documented that EDTA , doxycycline , , ilomostat , alpha1PI , and ES *inhibited* [MMP] activity in vitro . Negative_regulation MMP28 NA 20651358 2293184 *reduced* the number of annexin V-positive cells and [MMP] ( Delta Psi ( m ) ) loss by MG132 . Negative_regulation MMP28 NA 20674558 2311729 DP increased the levels of reactive oxygen species ( ROS ) in HepG2 cells , and antioxidant completely blocked DP-induced ROS accumulation and the disruption of the balance between Bax and Bcl-2 proteins , and effectively *blocked* the decreased [MMP] and apoptosis , but had no effect on the activation of caspase-8 and the up-regulations of DR4 and DR5 induced by DP . Negative_regulation MMP28 NFKB1 20188213 2236895 Additionally , by altering transcription activity in FLSs , curcumin *inhibited* PGE ( 2 ) production , COX-2 expression , and [MMP] secretion . Negative_regulation MMP28 NFKBIA 12006388 940102 Human macrophages and rabbit foam cells secreted [matrix degrading metalloproteinase (MMP)-9] without further stimulation , and this was not *inhibited* by ( 11+/-16 % and 8+/-10 % , respectively ; Negative_regulation MMP28 NOS1 11971672 933627 This study tested the hypothesis that inhibition in whole aortic wall *causes* increases in cytokine stimulated [MMP] and TIMP expression . Negative_regulation MMP28 NOX1 17543193 1668411 The endothelial cell NADPH oxidase and endothelial cell [MMP] activities are *required* for VCAM-1 dependent lymphocyte migration as determined by scavenging of ROS , by pharmacologic or antisense inhibition of and by pharmacologic inhibition of endothelial cell MMPs . Negative_regulation MMP28 NOX3 17543193 1668412 The endothelial cell NADPH oxidase and endothelial cell [MMP] activities are *required* for VCAM-1 dependent lymphocyte migration as determined by scavenging of ROS , by pharmacologic or antisense inhibition of and by pharmacologic inhibition of endothelial cell MMPs . Negative_regulation MMP28 NOX4 17543193 1668413 The endothelial cell NADPH oxidase and endothelial cell [MMP] activities are *required* for VCAM-1 dependent lymphocyte migration as determined by scavenging of ROS , by pharmacologic or antisense inhibition of and by pharmacologic inhibition of endothelial cell MMPs . Negative_regulation MMP28 NOX5 17543193 1668410 The endothelial cell NADPH oxidase and endothelial cell [MMP] activities are *required* for VCAM-1 dependent lymphocyte migration as determined by scavenging of ROS , by pharmacologic or antisense inhibition of and by pharmacologic inhibition of endothelial cell MMPs . Negative_regulation MMP28 OSM 17469134 1737467 and TNF stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP28 PAF1 23911909 2840206 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Negative_regulation MMP28 PAK1 22416254 2612584 To investigate the *role* of in regulating migration , invasion and [MMP] expression in RA fibroblast-like synoviocytes ( FLS ) . Negative_regulation MMP28 PAK1 23744893 2807129 Together , these data illustrate the complex interaction between the substratum and PRL/PAK1 signaling in human breast cancer cells and suggest a pivotal *role* for PRL dependent tyrosyl phosphorylation in [MMP] secretion . Negative_regulation MMP28 PARK7 22687481 2611740 Mitochondrial [membrane potential (MMP)] was decreased in MDA-MB-435 cells by BCA , and overexpression *inhibited* BCA induced MMP decrease in these cells . Negative_regulation MMP28 PDGFB 17099219 1676219 *inhibited* the synthesis and secretion of all hypoxia dependent [MMP] via Erk1/2 mitogen activated protein (MAP) kinase activation . Negative_regulation MMP28 PDLIM7 17913445 1812844 To investigate the *role* of in [MMP] expression in NPC , we cloned the LMP1 gene from NPC samples and transiently expressed it in MRC5 cells ( human lung fibroblasts ) . Negative_regulation MMP28 PIK3CA 16142341 1451112 Inhibition of signaling in LM8 by a PI3K inhibitor , LY294002 , or by a dominant negative form of Akt , *resulted* in suppression of [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Negative_regulation MMP28 PIK3R1 16142341 1451113 Inhibition of signaling in LM8 by a PI3K inhibitor , LY294002 , or by a dominant negative form of Akt , *resulted* in suppression of [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Negative_regulation MMP28 PLAT 22244977 2564133 We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle , delayed alone , or combined tPA ( 10 mg/kg , i.v. ) plus GM6001 ( 100 mg/kg , i.p. ) , a broad-spectrum [MMP] *inhibitor* . Negative_regulation MMP28 PLAU 12117412 997452 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Negative_regulation MMP28 PLAU 24418973 2942374 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 in the conditioned media . Negative_regulation MMP28 PLAUR 18548111 1984134 In conclusion , this study suggests that the absence of not only *regulates* fibrosis related gene expression and [MMP] activity but also results in ECM deposition . Negative_regulation MMP28 PLAUR 18987331 2021991 Interleukin 11 ( 100 ng/ml ) had no effect on matrix metallopeptidases 2 and 9 ( MMP2 and MMP9 ) , tissue *inhibitors* of [MMP] ( TIMP1 , TIMP2 , and TIMP3 ) , plasminogen activator urokinase (PLAU) , plasminogen activator urokinase receptor ( ) , and serpin peptidase inhibitors 1 and 2 ( SERPINE1 and SERPINE2 ) in EVT conditioned media and/or cell lysates . Negative_regulation MMP28 PLG 17574041 1754336 Migration assays were performed in the presence of K with and without the inhibitors ( aprotinin and -aminocaproic acid ) , the Galphai inhibitor Pertussis toxin , the [MMP] inhibitor ( GM6001 ) , the PI3-K inhibitors , Wortmannin and LY294002 , and the MAPK inhibitors PD98089 ( MEK1 inhibitor ) and SB203580 ( p38 ( MAPK ) *inhibitor* ) . Negative_regulation MMP28 PMS1 23902346 2840019 Collectively , these results suggest that quercetin inhibits cell motility via the inhibition of [MMP] activation in HT1080 cells in the *presence* and absence of . Negative_regulation MMP28 PMS2 23902346 2840020 Collectively , these results suggest that quercetin inhibits cell motility via the inhibition of [MMP] activation in HT1080 cells in the *presence* and absence of . Negative_regulation MMP28 PPARG 14742672 1203476 Here , we test the hypothesis that CDDO and 15-dPGJ2 use to *repress* [MMP] gene expression . Negative_regulation MMP28 PRDX2 23575963 2804302 All of the HDAC inhibitors prevented degradation of BNC , in which and MS-275 *repressed* cytokine induced [MMP] expression . Negative_regulation MMP28 RAPGEF1 10811109 692969 In contrast , expression of dominant negative did not *suppress* [MMP] secretion , although it substantially blocked the c-Jun N-terminal kinase activation . Negative_regulation MMP28 RB1 23258984 2709118 Among the GSs , most effectively *inhibited* [MMP] activity . Negative_regulation MMP28 RBBP4 20144149 2236018 The present study demonstrates that [MMP28] expression is *induced* by ( histone deacetylase ) inhibitors and that this effect is mediated through the GT-box . Negative_regulation MMP28 RBBP7 20144149 2236019 The present study demonstrates that [MMP28] expression is *induced* by ( histone deacetylase ) inhibitors and that this effect is mediated through the GT-box . Negative_regulation MMP28 RECK 12447698 1018169 In this study , we test the possibility that NSAIDs may up-regulate to *inhibit* [MMP] activity . Negative_regulation MMP28 RECK 12810630 1102707 In this study , we test the possibility that HDAC inhibitor may increase expression to *inhibit* [MMP] activation and cancer cell invasion . Negative_regulation MMP28 RECK 15604273 1346864 TIMP-2 and Ala+TIMP-2 also suppress basal hMVEC migration via a time dependent mechanism mediated by enhanced expression of , a membrane anchored [MMP] *inhibitor* , which , in turn , inhibits cell migration . Negative_regulation MMP28 RECK 16491114 1581793 We previously demonstrated that TIMP-2 increases the association of Crk with C3G and via subsequent activation of Rap1 enhances the expression of , a membrane anchored [MMP] *inhibitor* . Negative_regulation MMP28 RECK 18300271 1911989 Here , we examined the expression of , a novel membrane anchored [MMP] *inhibitor* , in PSCs . Negative_regulation MMP28 RECK 19270735 2045657 We silenced expression of three insect-type Tribolium [MMP] paralogs and their physiological *inhibitors* , TIMP and , by dsRNA mediated genetic interference ( RNAi ) . Negative_regulation MMP28 RECK 22227894 2605475 TIMP-2 , the most studied member of the family , can both inhibit and activate MMPs directly , as well as *inhibit* [MMP] activity indirectly by upregulating expression of , a membrane anchored MMP regulator . Negative_regulation MMP28 RECK 22260435 2551300 Matrix metalloproteinases ( MMPs ) and their inhibitors , known as tissue inhibitors of MMPs ( TIMPs ) , and the membrane associated [MMP] *inhibitor* ( ) , are essential for the metastatic process . Negative_regulation MMP28 REG1A 23516491 2761600 Furthermore , the results also revealed that the opening of MPTPs and the loss of [MMP] induced by azadirachtin could be significantly *inhibited* by the inhibitor cyclosporin A ( CsA ) , which was used to identify the key role of mitochondria in the apoptosis of Sf9 cells . Negative_regulation MMP28 RELA 20188213 2236896 Additionally , by altering transcription activity in FLSs , curcumin *inhibited* PGE ( 2 ) production , COX-2 expression , and [MMP] secretion . Negative_regulation MMP28 RETN 21277149 2403288 Furthermore , activated PKCe , but selective PKCe inhibitor *suppressed* resistin induced [MMP] expression , activity , and cell migration . Negative_regulation MMP28 RLN1 16709614 1584585 Taken together , this study provides proof-of- principle that gene expression targeted to the mouse lungs can *result* in enhanced [MMP] activity offering potential for alleviating disease conditions characterized by dysregulation of extracellular matrix protein accumulation . Negative_regulation MMP28 RLN2 16709614 1584586 Taken together , this study provides proof-of- principle that gene expression targeted to the mouse lungs can *result* in enhanced [MMP] activity offering potential for alleviating disease conditions characterized by dysregulation of extracellular matrix protein accumulation . Negative_regulation MMP28 RLN3 16709614 1584587 Taken together , this study provides proof-of- principle that gene expression targeted to the mouse lungs can *result* in enhanced [MMP] activity offering potential for alleviating disease conditions characterized by dysregulation of extracellular matrix protein accumulation . Negative_regulation MMP28 SARS 16127601 655727 The opening session was chaired by Stanislaw Pikul ( Procter and Gamble Co , OH , USA ) and included talks covering aspects of the syntheses and of corticotropin releasing hormone antagonists , serine proteinase , [matrix metalloproteinase (MMP)] and cysteine proteinase *inhibitors* . Negative_regulation MMP28 SERPINA1 18250185 1924637 These findings suggest a novel role for *inhibition* of NE-induced upregulation of [MMP] and cathepsin expression both in vitro and in vivo . Negative_regulation MMP28 SERPINE1 21465481 2523772 During wound healing , elevated levels of *inhibit* uPA/tPA/plasmin and plasmin dependent [MMP] activities , and , thus , help expedite wound healing . Negative_regulation MMP28 SIRT1 20426787 2315397 We examined if is *involved* in the regulation of [matrix metalloproteinase (MMP)] expression in human dermal fibroblasts . Negative_regulation MMP28 SNAP25 21395558 2447958 ( S-nitroso-N-acetylpenicillamine ) , a NO ( nitric oxide ) donor , and 8-Br-cGMP ( 8-bromo-cGMP ) *inhibited* thapsigargin induced Ca2+ entry and [MMP] secretion in the invasive potential of human SMMC-7721 cells . Negative_regulation MMP28 SNAP25 21437907 2523568 MPs lacked the MMP inhibitors TIMP-1 and TIMP-2 found in the Sup and , while strongly *inhibited* [MMP] activities but MPs did not . Negative_regulation MMP28 SP1 20488920 2288793 CDDO-Me also induced reactive oxygen species ( ROS ) and decreased mitochondrial membrane potential (MMP) in Panc1 and L3.6pL cells , and cotreatment with antioxidants ( glutathione and dithiothreitol ) blocked the formation of ROS , reversed the loss of [MMP] , and *inhibited* down-regulation of , Sp3 , and Sp4 . Negative_regulation MMP28 SPN 19491303 2102888 was found to *inhibit* [MMP] production in pro-inflammatory cytokine stimulated chondrocytes . Negative_regulation MMP28 STAT1 17875686 1796163 Despite the fact that silencing of was not *sufficient* to alter the [MMP] , STAT1 deficiency , like Ras mutations , sensitized cells to apoptosis induced by HDACi . Negative_regulation MMP28 TAB1 23962703 2909496 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , mitogen activated protein kinases (MAPK) : mitogen activated protein kinase kinase kinase 7 ( ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP28 TCF7L2 23603903 2800130 Overexpression of , but not of TCF3 or LEF1 , *induced* MMP-1 , -3 , and -13 expression and generic [MMP] activity in human chondrocytes . Negative_regulation MMP28 TFPI2 20015200 2488998 Moreover , down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in a ( 1 ) integrin on cell surface , and *increased* [MMP] expression ( mainly MMP-1 and -3 ) contributing to cancer cell invasion through basement membrane components . Negative_regulation MMP28 TGFB1 10390144 626168 [MMP] activity can be *down-regulated* by ( TGF-beta1 ) , a growth modulating factor , found in high concentrations in the bone . Negative_regulation MMP28 TGFB1 15247230 1289637 Because transforming growth factor-beta1 ( TGF-beta1 ) promotes tumor invasion in advanced squamous cell carcinomas , the *role* of in the regulation of [MMP] activity in a cellular model of invasive oral squamous cell carcinoma was examined . Negative_regulation MMP28 TGFB1 16236725 1476788 Furthermore , exogenous potentially rescued emphysema-like phenotype and concomitantly *reduced* [MMP] expression in Fut8 ( -/- ) lung . Negative_regulation MMP28 THBS1 10900205 736815 Tissue culture and in vitro assays demonstrated that the presence of purified TSR and intact *resulted* in inhibition of [MMP] activity . Negative_regulation MMP28 THBS1 17266545 1691495 In addition , *mediated* inhibition of [MMP] activity may decrease adverse remodeling . Negative_regulation MMP28 THBS1 22798012 2645617 This effect resulted from the presence of the potent [MMP] *inhibitors* , tissue inhibitor of metalloproteinases-1 ( TIMP-1 ) , type-1 plasminogen activator inhibitor ( PAI-1 ) and in the amnion dressings , as shown by real-time fluorescence zymography and protein microarrays . Negative_regulation MMP28 THBS2 21479427 2009759 In this study , we examined the *role* of in tumor cell invasion and its association with proteolytic proteins , [matrix metalloproteinase (MMP)] and the plasminogen/plasmin system , including urokinase-type plasminogen activator ( uPA ) , in the human pancreatic cancer cell line PANC-1 . Negative_regulation MMP28 TIMP1 10207248 561191 Functional and immunochemical approaches were used to assess [matrix metalloproteinase (MMP)] *inhibitors* , e.g. , and 2 ( TIMP-1 and TIMP-2 ) , in organ cultures of normal human skin maintained under growth factor free conditions or in medium supplemented with a combination of growth factors including epidermal growth factor , insulin , and pituitary extract . Negative_regulation MMP28 TIMP1 10330038 614036 We analyzed 1 ) collagen metabolism by [ 3H ] proline incorporation , 2 ) [matrix metalloproteinase (MMP)] expression by substrate gel zymography , and 3 ) tissue *inhibitor* of metalloproteinases ( ) expression by Western blot analysis . Negative_regulation MMP28 TIMP1 10430768 633607 To define the role of metalloproteinases ( MMPs ) in the development of lipid-rich atherosclerotic lesions in relation to the balance between proteolytic and antiproteolytic activities , we investigated the impact of adenovirus mediated elevation in the circulating levels of human tissue *inhibitor* of [MMP] ( ) in atherosclerosis-susceptible apolipoprotein E-deficient ( apoE ( -/- ) ) mice . Negative_regulation MMP28 TIMP1 10537164 563056 In this study , we have examined the physiological regulation pattern and cellular distribution of messenger RNAs coding for gelatinase A ( MMP-2 ) , collagenase-3 ( MMP-13 ) , membrane type MMP 1 ( MT1-MMP , MMP-14 ) , and the major [MMP] *inhibitor* , in the CL of adult pseudopregnant (psp) rat . Negative_regulation MMP28 TIMP1 10851028 701532 Data on changes in mRNA expression for the [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) in various forms of diabetic nephropathy are presented . Negative_regulation MMP28 TIMP1 10914842 716551 The findings indicate that estrogen exerts a stimulatory effect , while progesterone has an inhibitory effect on the expression of MMP , their tissue *inhibitors* ( ) , and enzymatic activity of [MMP] produced by these cells . Negative_regulation MMP28 TIMP1 11261483 764393 Tumour invasion and trophoblastic invasion share the same biochemical mediators : the [matrix metalloproteinases (MMP)] and their *inhibitors* ( ) . Negative_regulation MMP28 TIMP1 11274326 797619 The authors quantitatively measured levels of [matrix metalloproteinases (MMP)] , tissue *inhibitor* of metalloproteinases ( ) , and vascular endothelial growth factor ( VEGF ) in blood samples of POEMS syndrome . Negative_regulation MMP28 TIMP1 11279294 798530 Mammalian ovaries express a number of [matrix metalloproteinases (MMP)] and their tissue *inhibitors* ( ) . Negative_regulation MMP28 TIMP1 11420387 830597 [Matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) are major regulators of tissue remodelling of the extracellular matrix (ECM) and may also be involved in the control of growth factor availability . Negative_regulation MMP28 TIMP1 11466032 839738 [Matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) have been found in high concentrations in pleural effusions . Negative_regulation MMP28 TIMP1 11468168 840845 Two [MMP] *inhibitors* , and Ro 32-1541 , did not block L-selectin shedding and had no effect on lymphocyte migration across HEVs . Negative_regulation MMP28 TIMP1 11522015 852627 The concentrations of t-PA , PAI-1 , collagenase ( MMP-1 ) , tissue *inhibitor* of [MMP] ( ) , plasmin-antiplasmin (PAP) complexes and alpha2-macroglobulin (alpha2-M) were measured in plasma samples . Negative_regulation MMP28 TIMP1 11730752 884969 To assess the presence of matrix metalloproteinase ( MMP-1 ) and tissue *inhibitor* of [MMP] ( ) in peritoneal fluid and serum of subjects with and without adhesions . Negative_regulation MMP28 TIMP1 11730753 885009 To compare expression of matrix metalloproteinase ( MMP-1 ) and tissue *inhibitor* of [MMP] ( ) in serosal tissue of intraperitoneal organs and adhesions . Negative_regulation MMP28 TIMP1 11792149 901833 Genetic therapy aimed at disturbing the balance between [matrix metalloproteinases (MMP)] and their natural tissue *inhibitors* ( ) in treatment of pancreatic cancer requires an understanding of whether MMP and TIMP are tumor- or host derived . Negative_regulation MMP28 TIMP1 11813512 892787 This is further substantiated by the finding that smooth muscle cell (SMC) migration and neointima formation after vascular injury is significantly enhanced in mice with deficiency of , the main physiological [MMP] *inhibitor* . Negative_regulation MMP28 TIMP1 11841792 912199 , the physiological [MMP] *inhibitor* , increased during granulocytic differentiation whereas TIMP-2 did not significantly vary . Negative_regulation MMP28 TIMP1 11886844 919978 When Jurkat cells were stimulated with PMA in the presence of a BB94 , a [matrix metalloproteinase (MMP)] *inhibitor* , but not tissue inhibitor of metalloproteinase-1 ( ) , the release of galectin-9 was suppressed in a dose dependent manner . Negative_regulation MMP28 TIMP1 11985514 935690 We studied the [matrix metalloproteinase (MMP)] and their tissue *inhibitor* ( ) expression pattern in experimental autoimmune encephalomyelitis ( EAE ) of the resistant Th2 prone BALB/c mouse , where the disease can be induced with ultrasound emulsified antigen/adjuvant ( son-ag ) , but not with conventional technique ( syr-ag ) . Negative_regulation MMP28 TIMP1 11988491 936328 These data suggest that enhanced [MMP] activity , as a *result* of deficiency , contributes to a reduction of atherosclerotic plaque size but promotes aneurysm formation . Negative_regulation MMP28 TIMP1 12034400 948714 Alterations in [MMP] expression and their endogenous *inhibitor* ( ) may factor in HCC metastasis . Negative_regulation MMP28 TIMP1 12053120 951009 Here , we determine changes in the [matrix metalloproteinases (MMP)] and their tissue *inhibitors* ( ) in relation to ECM production and the progression of renal fibrosis in subtotally nephrectomized ( SNx ) rats . Negative_regulation MMP28 TIMP1 12118337 964797 Furthermore , RT-PCR showed that ACLA increased MMP-9 and tissue *inhibitor* of [MMP] ( ) expression in a ROS dependent manner . Negative_regulation MMP28 TIMP1 12468644 1022642 Comparison of mRNA levels of a panel of collagens , [matrix metalloproteinases (MMP)] , tissue *inhibitors* of metalloproteinases ( ) and cathepsins in the samples revealed higher levels of type I collagen , MMP-2 and cathepsin H and decreased levels of TIMP-3 mRNA in mid-secretory endometrium of patients with unexplained infertility and/or recurrent miscarriages when compared with normal mid-secretory endometrium . Negative_regulation MMP28 TIMP1 12506070 1038296 TNFalpha is a strong modulator expression of trabecular meshwork ( TM ) [matrix metalloproteinase (MMP)] and tissue *inhibitor* ( ) . Negative_regulation MMP28 TIMP1 12557216 1051817 To characterize differences in ear wounding responses between regenerating and nonregenerating mice , we examined and compared the extracellular matrix remodeling and the [matrix metalloproteinase (MMP)] and tissue *inhibitor* of metalloproteinase ( ) response in the MRL and C57BL/6 mouse strains after injury . Negative_regulation MMP28 TIMP1 12708162 1082898 Participation of [matrix metalloproteinases (MMP)] and their tissue *inhibitors* ( ) in the rupture of fetal membranes ( FM ) during labor has been proposed . Negative_regulation MMP28 TIMP1 1339165 209176 As serum markers for hepatitis fibrosis , prolyl hydroxylase ( PH ) , type III procollagen peptide ( PIIIP ) , type IV collagen , [mesenchymal metalloproteinase (MMP)] , tissue *inhibitor* of metalloproteinase ( ) and laminin are reliable for clinical application . Negative_regulation MMP28 TIMP1 1392165 198795 These MMPs and the [MMP] tissual *inhibitor* ( ) were detected by immunohistochemistry in 30 benign and 79 malignant lesions of the breast . Negative_regulation MMP28 TIMP1 14644158 1171991 In addition , , a natural [MMP] *inhibitor* , significantly reduced the invasion of RhoAV14 expressing cells , suggesting that MMP-9 was a critical metalloproteinase responsible , at least partly , for the RhoAV14 induced endothelial cell invasion . Negative_regulation MMP28 TIMP1 14729679 1220056 It was blocked by synthetic [MMP] *inhibitors* , TIMP2 , but not and abolished by a partial deletion of the catalytic domain or the cytoplasmic tail of MT1-MMP . Negative_regulation MMP28 TIMP1 14966582 1182611 To study the expression of [matrix metalloproteinase(MMP)] and tissue *inhibitor* of metalloproteinase ( ) in ameloblastoma ( AB ) and to determine the relationship between biological behavior of AB and clinical pathology . Negative_regulation MMP28 TIMP1 14990551 1256992 The purpose of this study was to investigate the effects of high-force eccentric muscle contractions on collagen remodeling and on circulating levels of [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) in humans . Negative_regulation MMP28 TIMP1 15162254 1252965 [Matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) have been found by ELISA and gelatine zymography in different concentrations in pleural fluid in tuberculous ( TB ) pleuritis . Negative_regulation MMP28 TIMP1 15364860 1294384 gene transfer *inhibits* [MMP] activity and preserves cardiac function and geometry in ischemic cardiomyopathy . Negative_regulation MMP28 TIMP1 15364874 1294408 We hypothesized that removal of the primary endogenous aortic [MMP] *inhibitor* ( ) through TIMP-1 gene deletion will increase TAA progression . Negative_regulation MMP28 TIMP1 15389186 1300369 We investigated the expression of [matrix metalloproteinase (MMP)] and its tissue *inhibitor* ( ) in fibrous plaques , angiofibromas , and lesion-free skin specimens from patients with tuberous sclerosis complex . Negative_regulation MMP28 TIMP1 15390257 1334911 ( TIMP-1 ) , a natural [MMP] *inhibitor* , was shown to reduce metastasis in different models . Negative_regulation MMP28 TIMP1 15502710 1327328 The [MMP] *inhibitors* , and TIMP-2 , were significantly reduced in the urine of mice with normally regenerating livers but were increased in the urine of mice treated with TNP-470 on day 8 . Negative_regulation MMP28 TIMP1 15781321 1385518 [Matrix metalloproteinases (MMP's)] and tissue *inhibitors* of metalloproteinases ( 's ) possess a preponderant role in the metabolism of the major extracellular matrix protein , collagen , and are thought to be important in the mechanism of tumor invasion . Negative_regulation MMP28 TIMP1 15795420 1387207 Total collagen IV , the different alpha ( IV ) chains , matrix degrading metalloproteinases ( [MMP] ) , and tissue *inhibitors* of metalloproteinases ( ) were quantified by immunocytochemistry and/or Western blotting . Negative_regulation MMP28 TIMP1 15980226 1424674 At various time points after injury ( PI ) , corneas from the Tbeta4- versus the PBS treated group were examined for polymorphonuclear leukocyte ( PMN ) infiltration , chemokine , and [matrix metalloproteinase (MMP)/tissue] *inhibitor* of metalloproteinase ( ) expression . Negative_regulation MMP28 TIMP1 16019435 1432044 Either human or bovine *inhibited* [matrix metalloproteinase (MMP)] activities , such as collagenolytic , gelatinolytic and caseinolytic , expressed by mouse cells as well as those expressed by human cells . Negative_regulation MMP28 TIMP1 16051697 1466136 Abnormal expression of matrix components [ collagen IV , fibronectin , matrix metalloproteinase 9 (MMP-9) and [MMP] tissue *inhibitor* 1 ( ) ] was also significantly reversed by iptakalim . Negative_regulation MMP28 TIMP1 16110415 1445308 [Matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) play a crucial role in physiological and pathological matrix turnover . Negative_regulation MMP28 TIMP1 16500763 1528973 Expression of collagen , [matrix metalloproteinase (MMP)] , and tissue *inhibitor* of metalloproteinase-1 ( ) were determined by real-time PCR . Negative_regulation MMP28 TIMP1 16574944 1598106 The [MMP] *inhibitors* , and TIMP-2 , were also increased at 7-28 d after asbestos exposure . Negative_regulation MMP28 TIMP1 17045020 1635654 OPN can protect against hyperoxia induced ALI by promoting the expression of and *inhibiting* the activation of [MMP] . Negative_regulation MMP28 TIMP1 17334003 1707567 The lowest concentrations of [MMP] *inhibitor* ( ) were observed in patients with periodontitis , in whom the concentrations increased after periodontal treatment . Negative_regulation MMP28 TIMP1 17336841 1707652 We profiled the expression of the entire [matrix metalloproteinase (MMP)] , tissue *inhibitor* of metalloproteinases ( ) , and a disintegrin and metalloproteinase domain with thrombospondin motif ( ADAMTS ) gene families in these tissues using real-time reverse-transcription polymerase chain reaction . Negative_regulation MMP28 TIMP1 17543340 1888666 We examined expression patterns of [matrix metalloproteinase (MMP)] , tissue *inhibitor* of metalloproteinase ( ) , and reversion inducing cysteine-rich protein with Kazal motifs ( RECK ) in colorectal cancer tissues to assess their prognostic significance . Negative_regulation MMP28 TIMP1 17868665 1796038 [Matrix metalloproteinases (MMP)] and tissue *inhibitor* of metalloproteinases ( ) trigger the signal cascade instigating cardiac remodeling and fibrosis , which lead to changes of repolarization variables . Negative_regulation MMP28 TIMP1 17942699 1814046 Low exogenous NO perturbed [MMP/tissue] *inhibitor* of metalloproteinase ( ) -1 levels by enhancing MMP activity and suppressing the endogenous inhibitor TIMP-1 . Negative_regulation MMP28 TIMP1 18493720 1939294 Degradation and remodelling of the extracellular matrix has been investigated , with the main focus on the balance between [matrix metalloproteinases (MMP)] and tissue *inhibitor* of metalloproteinases ( ) . Negative_regulation MMP28 TIMP1 18826601 1981607 Balance between [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) in the cervical mucus plug estimated by determination of free non complexed TIMP . Negative_regulation MMP28 TIMP1 19134356 2005764 To investigate the roles of [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) in dentinogenic ghost cell tumor ( DGCT ) and ghost cell odontogenic carcinoma ( GCOC ) . Negative_regulation MMP28 TIMP1 19262092 1841132 Gelatin and reverse zymogram assays were used to determine the enzyme activities of [matrix metalloproteinases (MMP)] and tissue *inhibitor* of metalloproteinases ( ) . Negative_regulation MMP28 TIMP1 19270735 2045658 We silenced expression of three insect-type Tribolium [MMP] paralogs and their physiological *inhibitors* , and RECK , by dsRNA mediated genetic interference ( RNAi ) . Negative_regulation MMP28 TIMP1 19627579 2137619 [Matrix metalloproteinase (MMP)] and tissue *inhibitor* ( ) were assessed by ELISA and zymography . Negative_regulation MMP28 TIMP1 19698156 2126747 To evaluate levels of [matrix metalloproteinases (MMP)] and their *inhibitors* ( ) in second trimester amniotic fluid of women with hypertensive disorders compared to normotensive women . Negative_regulation MMP28 TIMP1 20531021 2295536 We compared specific matrix metalloproteinases ( MMP-2 and MMP-9 ) and 1 [MMP] *inhibitor* ( ) activities or expression in human milk ( HM ) fed to 18 preterm infants and 13 full-term infants , obtained at 72 hours and 1 and 2 weeks postpartum . Negative_regulation MMP28 TIMP1 20581102 2309119 Nitric oxide ( NO ) is a potential regulator of matrix metalloproteinase (MMP) activity in [MMP-NO-tissue] *inhibitor* of metalloproteinase ( ) inhibitory tertiary complex . Negative_regulation MMP28 TIMP1 20621951 2286780 [Matrix metalloproteinases (MMP)] and tissue *inhibitor* of matrix metalloproteinase-1 ( ) are involved in blood brain barrier disruption and formation of MS lesions . Negative_regulation MMP28 TIMP1 20654099 2297928 To compare right atrial structural remodeling and the expression of [matrix metalloproteinase (MMP)] and tissue *inhibitors* ( ) between patients with unstable angina ( UA ) and myocardial infarction ( MI ) . Negative_regulation MMP28 TIMP1 21033407 2181975 Metalloproteinases ( [MMP] ) and their tissue *inhibitors* ( ) play a crucial role to keep the balance between the synthesis and degradation of extracellular matrix protein . Negative_regulation MMP28 TIMP1 21105842 2395777 In diseased pulmonary arteries , the balance between [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) is broken down . Negative_regulation MMP28 TIMP1 21148111 2390188 Tissue *inhibitor* of [MMP] ( ) was elevated with age but protected by ET . Negative_regulation MMP28 TIMP1 22033229 2527408 This broader view reflects our emerging understanding that signaling and [MMP] *inhibition* represent two important functions of TIMPs that have the potential to affect tissue pathology . Negative_regulation MMP28 TIMP1 22042083 2540076 This effect may be partially mediated by increased MMP-2 and activities in the aortic wall and *reduced* TNFa stimulated inflammation and [MMP] activation in macrophages . Negative_regulation MMP28 TIMP1 22467128 2578587 The production of , an endogenous [matrix metalloproteinase (MMP)] *inhibitor* , was observed in CBA/J mice . Negative_regulation MMP28 TIMP1 22591289 2632124 [Matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) have been implicated in chronic obstructive pulmonary disease ( COPD ) pathogenesis . Negative_regulation MMP28 TIMP1 22798012 2645618 This effect resulted from the presence of the potent [MMP] *inhibitors* , ( TIMP-1 ) , type-1 plasminogen activator inhibitor ( PAI-1 ) and thrombospondin-1 (TSP-1) in the amnion dressings , as shown by real-time fluorescence zymography and protein microarrays . Negative_regulation MMP28 TIMP1 23071737 2689993 Next , in vivo Near-InfraRed-Fluorescence imaging demonstrated that electroporation mediated *reduced* local [MMP] activity in vein grafts by 73 % ( p < 0.01 ) . Negative_regulation MMP28 TIMP1 23073243 2735298 Cardiovascular remodeling found in later phases of two-kidney , one-clip ( 2K1C ) hypertension may involve key mechanisms particularly including MMP-2 , oxidative stress , transforming growth factor-ß ( TGF-ß ) , and inactivation of the endogenous [MMP] *inhibitor* , the . Negative_regulation MMP28 TIMP1 23100416 2690945 Moreover , noise induced expression changes in two endogenous [MMP] *inhibitors* , and Timp2 , in sensory cells were dependent on the stage of nuclear condensation , suggesting a specific role for MMP activity in sensory cell apoptosis . Negative_regulation MMP28 TIMP1 23218521 2786053 In this study , we examined the expression patterns of MMP-13 and [MMP] *inhibitors* , and TIMP-2 , in immature ( 4weeks ) , pre-pubertal ( 16weeks ) , and mature ( 1year ) chicken testes . Negative_regulation MMP28 TIMP1 23493620 2803918 Functional inhibition of TIMP-1 prevented the KA-induced impairment of Reelin cleavage indicating that *inhibits* [MMP] activity . Negative_regulation MMP28 TIMP1 23583449 2783733 , a well-known [MMP] *inhibitor* , displays other biological activities such as cell survival , proliferation and differentiation in hematopoietic cells . Negative_regulation MMP28 TIMP1 24065532 2857729 In contrast , mRNA expression of tissue inhibitor of matrix metalloproteinase ( ) -1 , a [MMP] *inhibitor* , was increased by 10-120 µg/ml of PS but not that of TIMP-2 . Negative_regulation MMP28 TIMP1 24086305 2847772 As interplay of TNF-a , TGF-ß , [matrix metalloproteinases (MMP)] , and tissue *inhibitors* of metalloproteinases ( ) is important in wound healing in general , TNF-a , TGF-ß , MMP7 , and TIMP1 were assessed immunohistochemical in samples of wounded ears harvested on days 2 , 6 , 10 and 16 after wounding . Negative_regulation MMP28 TIMP1 24367771 2881834 Tissue *inhibitor* of [MMP] ( ) gene expression decreased after CPX treatment , whilst TIMP-2 and transforming growth factor-ß1 gene expression , the cytoskeleton arrangement , and cytochrome c expression remained unmodified . Negative_regulation MMP28 TIMP1 24471121 2884710 Our results showed that the core protein of NIPP-1 peptide prevented fibril formation of type I collagen , elevated the [MMP] level and *inhibited* production in a dose dependent manner . Negative_regulation MMP28 TIMP1 24766991 2939503 Variance of [matrix metalloproteinase (MMP)] and tissue *inhibitor* of metalloproteinase ( ) concentrations in activated , concentrated platelets from healthy male donors . Negative_regulation MMP28 TIMP1 7933807 275431 The present study was designed to assess whether expression of mRNA for extracellular matrix (ECM) components , metalloproteinases ( [MMP] ) and tissue *inhibitor* of metalloproteinases ( ) in glomeruli is affected by a low protein diet during the course of focal glomerulosclerosis (FGS) . Negative_regulation MMP28 TIMP1 7989608 282874 The [MMP] *inhibitors* , EDTA and 1,10-phenanthroline , as well as recombinant , reduced these activities which colocalized with regions of increased immunoreactive MMP expression , i.e. , the shoulders , core , and microvasculature of the plaques . Negative_regulation MMP28 TIMP1 8207529 261448 The role of [matrix metalloproteinases (MMP's)] and their *inhibitor* , ( TIMP-1 ) , in human brain tumor invasion was investigated . Negative_regulation MMP28 TIMP1 8686751 370304 The [MMP] *inhibitor* , , was expressed in both stromal and tumor components in most tumors , and neither stromelysin-2 nor neutrophil collagenase were detected in any of the tumors . Negative_regulation MMP28 TIMP1 8922288 396966 When the complex *inhibits* an [MMP] , a quaternary complex monomer/lipocalin/TIMP-1/MMP is generated which after activation shows a sixfold higher proteolytic activity than the active ternary complex . Negative_regulation MMP28 TIMP1 9276670 450733 Both a tissue inhibitor of metalloproteinases-1 ( ) and a synthetic hydroxamate [MMP] *inhibitor* prevented this collagen release . Negative_regulation MMP28 TIMP1 9438380 474973 Since angiogenesis does not occur in large blood vessels , we investigated whether the secretion of MMPs and tissue *inhibitor* of [MMP] ( ) differs between micro- and macro-vascular endothelial cells . Negative_regulation MMP28 TIMP1 9524323 494572 Calvariae produced a high level of [MMP] *inhibitor* ( ) , especially under the influence of the cytokines ; Negative_regulation MMP28 TIMP1 9570393 478026 To investigate the relation between [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) in malignant ovarian tumor , MMP and TIMP activities in conditioned media of 16 malignant ovarian tumor tissues and six normal ovaries were detected by zymography and reverse zymography , respectively and were quantitated with a densitometer . Negative_regulation MMP28 TIMP1 9804345 544250 To better understand the pathogenesis of ulcer formation we investigated the expression of [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) in lipodermatosclerosis . Negative_regulation MMP28 TIMP2 10642509 660870 In contrast , activation of pro-MMP-2 by [sMT1-MMP] was dose-dependently *inhibited* by . Negative_regulation MMP28 TIMP2 10818225 693842 The natural [MMP] *inhibitors* , and TIMP-4 were unable to inhibit ADAM-10 , but TIMP-1 and TIMP-3 were inhibitory . Negative_regulation MMP28 TIMP2 11346466 814268 MMP2 is activated by membranous type-1 MMP (MT1-MMP) and type-2 tissue *inhibitor* of [MMP] ( ) . Negative_regulation MMP28 TIMP2 11382769 835010 In contrast to the stimulatory effect of TIMP-2 on pro-MMP-2 activation by MT1-MMP , activation of pro-MMP-2 by [DeltaMT1-MMP] in the presence of claudin-5 and proDeltaMMP-2 processing by MT1-MMP were both inversely *repressed* by expression of exogenous . Negative_regulation MMP28 TIMP2 12269680 990648 To comparatively analyse the expression of matrix metalloproteinase ( MMP-3 ) and tissue *inhibitor* of [MMP] ( ) in serosal tissue of intraperitoneal organs and adhesions , as well as peritoneal fluid and serum of subjects with and without adhesions . Negative_regulation MMP28 TIMP2 12900406 1150253 To address these differences , a series of structure-function studies were conducted to identify and to characterize the anti-angiogenic domains of , the endogenous [MMP] *inhibitor* that uniquely inhibits capillary endothelial cell ( EC ) proliferation as well as angiogenesis in vivo . Negative_regulation MMP28 TIMP2 14593002 1176273 When small renal arteries were incubated with either of the general [MMP] *inhibitors* , GM6001 or ( tissue inhibitor of MMP ) , or with the specific gelatinase inhibitor , cyclic CTT , the reduced myogenic reactivity of these blood vessels from relaxin treated nonpregnant and midterm pregnant rats was totally abolished . Negative_regulation MMP28 TIMP2 14729679 1220057 It was blocked by synthetic [MMP] *inhibitors* , , but not TIMP-1 and abolished by a partial deletion of the catalytic domain or the cytoplasmic tail of MT1-MMP . Negative_regulation MMP28 TIMP2 15502710 1327329 The [MMP] *inhibitors* , TIMP-1 and , were significantly reduced in the urine of mice with normally regenerating livers but were increased in the urine of mice treated with TNP-470 on day 8 . Negative_regulation MMP28 TIMP2 16323056 1487995 The mRNA levels of preproET-1 , endothelin converting enzyme ( ECE-1 ) , ETa receptor and ETb receptor , matrix metalloproteinase ( MMP-2 ) , tissue *inhibitor* of [MMP] ( ) , and heat shock protein ( HSP-70 ) were determined by quantitative real-time RT-PCR . Negative_regulation MMP28 TIMP2 16574944 1598107 The [MMP] *inhibitors* , TIMP-1 and , were also increased at 7-28 d after asbestos exposure . Negative_regulation MMP28 TIMP2 20000122 2174789 The aim of this study was to elucidate peculiarity of expression of gelatinases A and B ( MMP-2 and MMP-9 ) , membrane type MMP ( MT1-MMP ) and tissue *inhibitor* of [MMP] ( ) in immortal ( IF ) and transformed fibroblasts ( TF ) . Negative_regulation MMP28 TIMP2 20626034 2321842 PACs increased the expression of , a known *inhibitor* of [MMP] activity , and decreased the expression of EMMPRIN , an inducer of MMP expression . Negative_regulation MMP28 TIMP2 23000197 2689203 The role of matrix metalloproteinases ( MMP-3 and MMP-9 ) , tissue *inhibitor* of [MMP] ( ) , and GAP-43 ( growth-associated-protein ) in neocerebellar vermis lobules during postnatal histogenesis was studied after challenge with cisplatin ( cisPt ) . Negative_regulation MMP28 TIMP2 23100416 2690946 Moreover , noise induced expression changes in two endogenous [MMP] *inhibitors* , Timp1 and , in sensory cells were dependent on the stage of nuclear condensation , suggesting a specific role for MMP activity in sensory cell apoptosis . Negative_regulation MMP28 TIMP2 23218521 2786054 In this study , we examined the expression patterns of MMP-13 and [MMP] *inhibitors* , TIMP-1 and , in immature ( 4weeks ) , pre-pubertal ( 16weeks ) , and mature ( 1year ) chicken testes . Negative_regulation MMP28 TIMP2 24640096 2886445 Results of comparative immunoenzymatic study of matrix metalloproteinase (MMP) 2 , 8 and 9 , interleukins ( IL ) If and 6 , tissue [MMP] *inhibitors* ( TIMP-1and ) and TNF-a in oral fluid of patients with different teeth and denture constructive materials show that MMP-9 content in oral fluid can serve as a marker of chronic generalized periodontitis because it is elevated in all patients irrespective of presence or absence of metallic tooth restorations . Negative_regulation MMP28 TIMP2 9009103 410892 The degradation of fluorogenic substrates by MMPs could be inhibited by the chelating agent EDTA and by the ( TIMP-2 ) , an [MMP-specific] *inhibitor* . Negative_regulation MMP28 TIMP3 11960708 932407 We examined the expression patterns of two [MMP] *inhibitors* , tissue inhibitor of metalloproteinase ( TIMP ) -2 and , during critical stages of cardiac development . Negative_regulation MMP28 TIMP3 18360715 1887807 Concomitantly , cell proliferation decreased and expression of prostate-specific antigen (PSA) mRNA and its secretion were diminished , whereas expression of IGF binding protein 3 (IGFBP-3) and [MMP] tissue *inhibitor* 3 ( ) was up-regulated . Negative_regulation MMP28 TIMP3 19795442 2209083 Gene array analysis revealed that blocking Snail expression suppressed the activity of matrix metalloproteinases ( MMPs ) and upregulated , an [MMP] *inhibitor* . Negative_regulation MMP28 TIMP3 9712149 527204 Transforming growth factor beta ( TGF-beta ) , an inducer of matrix synthesis , potently enhances mRNA and protein of a recently characterized [MMP] *inhibitor* , , in bovine articular chondrocytes . Negative_regulation MMP28 TIMP4 10818225 693843 The natural [MMP] *inhibitors* , TIMP-2 and were unable to inhibit ADAM-10 , but TIMP-1 and TIMP-3 were inhibitory . Negative_regulation MMP28 TIMP4 12707244 1086180 Loss of from the cardiac myocyte *leads* to an increase in net myocardial [MMP] activity that contributes to acute myocardial stunning injury . Negative_regulation MMP28 TIMP4 12923405 1131125 The increased levels of in the medulla may *inhibit* the collagenolytic activity of [MMP] but is unable to inhibit the elastinolytic activity . Negative_regulation MMP28 TIMP4 16682001 1559613 Despite the importance of MMP activity in the regulation of angiogenesis , relatively little is known about the role of , the most recently discovered endogenous [MMP] *inhibitor* , in modulating neovascularization . Negative_regulation MMP28 TNF 12506070 1038333 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in [MMP] and TIMP expression . Negative_regulation MMP28 TNF 15145598 1247695 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of [MMP] and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation MMP28 TNF 15663564 1350369 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Negative_regulation MMP28 TNF 16106101 1444989 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Negative_regulation MMP28 TNF 17469134 1737466 OSM and stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP28 TNF 19281093 2007615 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Negative_regulation MMP28 TNF 22202225 2518995 In addition , we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as ( TNF-B ) , interferon-alpha ( IFN-a ) , transforming growth factor-beta (TGF-B) , interleukins ( IL ) such as IL1-B and IL-6 , as well as [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( TIMP ) . Negative_regulation MMP28 TNFSF10 23582782 2778424 however , the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus *induced* loss of [MMP] and apoptosis . Negative_regulation MMP28 TNP1 10665843 578438 There was no induced *inhibition* of [MMP] collagenase activity or MMP ( MMP2 and MMP9 ) production in the human fibrosarcoma cells HT 1080 in vitro . Negative_regulation MMP28 TNP2 10665843 578439 There was no induced *inhibition* of [MMP] collagenase activity or MMP ( MMP2 and MMP9 ) production in the human fibrosarcoma cells HT 1080 in vitro . Negative_regulation MMP28 TSR1 10900205 736818 Tissue culture and in vitro assays demonstrated that the presence of purified and intact TSP1 *resulted* in inhibition of [MMP] activity . Negative_regulation MMP28 TSR2 10900205 736817 Tissue culture and in vitro assays demonstrated that the presence of purified and intact TSP1 resulted in *inhibition* of [MMP] activity . Negative_regulation MMP28 TSR3 10900205 736816 Tissue culture and in vitro assays demonstrated that the presence of purified and intact TSP1 *resulted* in inhibition of [MMP] activity . Negative_regulation MMP28 UTRN 22388349 2636721 Drp1 siRNA and small molecule inhibitors of *prevented* mitochondrial fission , loss of mitochondrial [membrane potential (MMP)] , and cell death induced by glutamate or tBid overexpression in immortalized hippocampal HT-22 neuronal cells . Negative_regulation MMP28 VEGFA 12600446 1062230 Blockade of ( VEGF ) and *inhibition* of [matrix metalloproteinases (MMP)] are promising therapies for cancer . Negative_regulation MMP28 VEGFA 12600446 1062274 Both blockade and [MMP] *inhibition* reduce primary tumor size , metastasis , and angiogenesis , thereby increasing survival in experimental pancreatic cancer . Negative_regulation MMP28 VIP 15096214 1238747 , at 10 ( -7 ) m , *reduced* CSE stimulated [MMP] activity and caspase-3 activation . Negative_regulation MMP28 WDR61 23911909 2840207 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Negative_regulation MMP28 WISP1 19180479 2033093 Adenoviral overexpression of in murine knee joints *induced* [MMP] and aggrecanase expression and resulted in cartilage damage . Negative_regulation MMP28 WNT1 22328140 2629735 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Negative_regulation MMP28 WNT11 22328140 2629736 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Negative_regulation MMP28 WNT16 22328140 2629741 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Negative_regulation MMP28 WNT2 22328140 2629737 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Negative_regulation MMP28 WNT3 22328140 2629738 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Negative_regulation MMP28 WNT4 22328140 2629739 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Negative_regulation MMP28 WNT6 22328140 2629740 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Negative_regulation MMP3 CAPN8 16574073 1543448 is *involved* in the regulation of TNF-alpha induced [matrix metalloproteinase-3] release in a rheumatoid synovial cell line . Negative_regulation MMP3 CHI3L1 15015934 1251094 *suppressed* the cytokine induced secretion of MMP1 , [MMP3] and MMP13 , as well as secretion of the chemokine IL-8 . Negative_regulation MMP3 CTGF 23827951 2820812 stimulation *resulted* in the significant production of IL-6 , IL-8 , C-C motif ligand 2 (CCL2) , CCL20 , MMP-1 and [MMP-3] in FLSs in the presence , but not in the absence , of IL-1ß . Negative_regulation MMP3 FAS 11980895 954090 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of [MMP] and cytochrome c release . Negative_regulation MMP3 HBEGF 17322418 1747791 Inhibition of ( HB-EGF ) release by CRM-197 and *inhibition* of [matrix metalloproteinases (MMP)] by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation . Negative_regulation MMP3 IL1B 12880581 1115756 The effects of DHEA on the gene expressions of [MMP-1 and -3] were more prominent in the *presence* of , in which DHEA suppressed not only MMP-1 , but also MMP-3 at the lower concentrations , 10 and 50 micro M , respectively . Negative_regulation MMP3 IL1B 16122880 1461094 A dose dependent inhibition of and TPA *stimulated* [MMP] activity by gallium nitrate at increasing concentrations occurs , demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis . Negative_regulation MMP3 MMP7 15103490 1301683 inhibition as well as *inhibition* of MMP-13 and [MMP-3] may be a useful preventive or therapeutic adjunct in colorectal cancer . Negative_regulation MMP3 PLAT 22244977 2564147 We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle , delayed tPA alone , or combined ( 10 mg/kg , i.v. ) plus GM6001 ( 100 mg/kg , i.p. ) , a broad-spectrum [MMP] *inhibitor* . Negative_regulation MMP3 PLAU 12117412 997466 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Negative_regulation MMP3 PLAU 24418973 2942388 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 in the conditioned media . Negative_regulation MMP3 TFPI2 20015200 2489012 Moreover , down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in a ( 1 ) integrin on cell surface , and *increased* [MMP] expression ( mainly MMP-1 and -3 ) contributing to cancer cell invasion through basement membrane components . Negative_regulation MMP3 TNF 12506070 1038347 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in [MMP] and TIMP expression . Negative_regulation MMP3 TNF 15145598 1247710 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of [MMP] and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation MMP3 TNF 15641080 1363007 Independent analyses of gene expression in cultured cartilage from 9 other OA patients revealed that or MMP-1 blockade , either alone and/or in combination , frequently *down-regulated* [MMP-3] , MMP-13 , and IL-1 expression . Negative_regulation MMP3 TNF 15663564 1350383 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Negative_regulation MMP3 TNF 16106101 1445003 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Negative_regulation MMP3 TNF 17060126 1637165 MMP-3 inhibition ameliorates intestinal damage without apparently affecting either TNF-alpha or TACE production and the dose-response curve suggests that the beneficial effect of the so-called TACE inhibitor is actually mainly mediated via [MMP-3] inhibition rather than *inhibition* . Negative_regulation MMP3 TNF 17469134 1737494 OSM and stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP3 TNF 19281093 2007629 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Negative_regulation MMP3 TNF 22202225 2519009 In addition , we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as ( TNF-B ) , interferon-alpha ( IFN-a ) , transforming growth factor-beta (TGF-B) , interleukins ( IL ) such as IL1-B and IL-6 , as well as [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( TIMP ) . Negative_regulation MMP3 TNF 24062615 2846672 We have demonstrated that budesonide concentration-dependently ( 10 ( -10 ) -10 ( -7 ) M ) inhibited IL-6 , IL-8 , MMP-1 , and [MMP-3] release by HFL-1 cells in *response* to IL-1ß plus . Negative_regulation MMP3 TNF 24641725 2925735 High levels of [act-MMP-3] expression were observed in human synovial membrane culture and oncostatin M and *stimulated* human cartilage . Negative_regulation MMP3 TNFSF10 23582782 2778438 however , the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus *induced* loss of [MMP] and apoptosis . Negative_regulation MMP7 A2M 12860260 1111218 Circulating levels of MMPs and TIMPs were associated neither with those of C-reactive protein , nor with those of ( a nonspecific [MMP] *inhibitor* ) , nor with intima-media thickness values . Negative_regulation MMP7 ACAN 23797671 2815543 Exposure of the explants to recombinant hTryptase-ß , recombinant mMCP-6 , or lysates harvested from WT mouse peritoneal MCs ( PMCs ) significantly increased the levels of enzymatically active [matrix metalloproteinases (MMP)] in cartilage and significantly *induced* loss into the conditioned media , relative to replicate explants exposed to medium alone or lysates collected from mMCP-6-null PMCs . Negative_regulation MMP7 ACE 10525103 653947 This study examined the effects of specific [MMP] inhibition , *inhibition* , and combined treatment on LV systolic and diastolic function in a model of CHF . Negative_regulation MMP7 ACE 17308006 1747468 This study sought to determine whether inhibitors can directly *regulate* [MMP] activity and whether this results in positive structural and functional adaptations to the heart . Negative_regulation MMP7 AKT1 16142341 1451184 Inhibition of signaling in LM8 by a PI3K inhibitor , LY294002 , or by a dominant negative form of Akt , *resulted* in suppression of [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Negative_regulation MMP7 AKT2 16142341 1451185 Inhibition of signaling in LM8 by a PI3K inhibitor , LY294002 , or by a dominant negative form of Akt , *resulted* in suppression of [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Negative_regulation MMP7 AKT3 16142341 1451186 Inhibition of signaling in LM8 by a PI3K inhibitor , LY294002 , or by a dominant negative form of Akt , *resulted* in suppression of [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Negative_regulation MMP7 APAF1 22226830 2550057 Altogether , we have for the first time demonstrated the critical *role* of in the regulation of MAPK , ROS , and [MMP] in UVC radiated MEFs and propose that the amplification feedback loop among mitochondrial signal molecules culminates in the demise of the cell . Negative_regulation MMP7 ARG1 15584904 1345427 Both a pseudosubstrate furin inhibitor , ( dec-RVKR-cmk ) , or alpha 1-anti-trypsin Portland ( PDX ) , a recombinant furin-inhibitory protein , *suppress* constitutive and BCL-2 mediated [MMP] activity and invasion . Negative_regulation MMP7 ARG2 15584904 1345428 Both a pseudosubstrate furin inhibitor , ( dec-RVKR-cmk ) , or alpha 1-anti-trypsin Portland ( PDX ) , a recombinant furin-inhibitory protein , *suppress* constitutive and BCL-2 mediated [MMP] activity and invasion . Negative_regulation MMP7 BAX 19513559 2092530 The WEPN treatment *induced* the upregulation of pro-apoptotic , downregulation of anti-apoptotic Bcl-2 expression and loss of mitochondrial [membrane potential (MMP)] , which was associated with the proteolytic activation of caspases and the concomitant degradation of poly ( ADP ribose ) polymerase ( PARP ) protein . Negative_regulation MMP7 BAX 22419111 2572728 Pharmacologic inhibitors of the permeability transition pore , inhibitors , and recombinant Bcl-2 and Bcl-XL proteins do not *reduce* Tat induced [MMP] . Negative_regulation MMP7 BCL2 17955488 1844600 Overexpression of in HN4 cells *prevented* loss of [MMP] , nuclear translocation of EndoG and protected cells from the delayed apoptosis induced by cisplatin in the presence of z-VAD-fmk . Negative_regulation MMP7 BCL2 23437193 2744540 Increased of reactive oxygen species ( ROS ) production , coupled with downregulation of anti-apoptotic molecules ( , Bcl-xL ) *led* to reduction of mitochondrial [membrane potential (MMP)] and release of cytochrome c in both human breast cancer cells treated with vernodalin . Negative_regulation MMP7 BNIP3 22292033 2545677 Although the overexpression of either or NIX did not *cause* a remarkable change in the mitochondrial [membrane potential (MMP)] , the co-expression of all three exogenous proteins , Mieap , BNIP3 and NIX , caused a dramatic reduction in MMP , implying that the physical interaction of Mieap , BNIP3 and NIX at the mitochondrial outer membrane may regulate the opening of a pore in the mitochondrial double membrane . Negative_regulation MMP7 BSG 16207318 1464241 The *role* of in [MMP] production and cell invasion in vitro were studied through the co-culture of human CD14+ monocytes or monocytic line THP-1 cells and human fibroblasts , as well as by gel zymography and an invasion assay . Negative_regulation MMP7 BSG 16507143 1574160 The *role* of in [MMP] production and the cells ' invasiveness in vitro were studied by the co-culture of FLS with the human THP-1 cell line or monocytes/macrophages , by gel zymography and by invasion assay . Negative_regulation MMP7 BSG 17869266 1843151 Expression of mutant *inhibited* the betaAR stimulated increases in MMP2 expression and zymographic [MMP] activity . Negative_regulation MMP7 BSG 18281245 1885228 The expression of extracellular matrix metalloproteinase inducer ( ) , matrix metalloproteinases ( MMPs ) , tissue *inhibitors* of [MMP] ( TIMPs ) and collagens were assessed by western blot analysis . Negative_regulation MMP7 BSG 19003972 2016238 We have analysed the *role* of in the induction of [MMP] genes during mammary gland differentiation and involution . Negative_regulation MMP7 BSG 20369361 2238549 The current results indicate that could thus be *involved* in the early stage of tooth germ development and morphogenesis , possibly by regulating the expression of [MMP] genes . Negative_regulation MMP7 CA2 18661233 2028106 Baicalein *induced* an increase in the cytoplasmic levels of ROS and in 1 h and reached their peak at 3 h , and thereafter a loss of [MMP] by flow cytometry . Negative_regulation MMP7 CD2 16458199 1522488 ( 25 microM ) *reduced* the mitochondrial [membrane potential (MMP)] as measured by flow cytometry . Negative_regulation MMP7 CD34 21122408 2355530 Circulating endothelial cells ( CECs ) were detected by flowcytometry , and the expression of matrix metalloproteinase ( MMP-2 , MMP-9 ) , the tissue *inhibitor* of [MMP] ( TIMP-1 , TIMP-2 ) , the extracellular MMP inducer ( EMMPRIN ) , , a-smooth muscle actin ( a-SMA ) were determined by immunohistochemistry . Negative_regulation MMP7 CD40 20921282 2337536 Furthermore , *induced* the IFN-?- and NO-dependent decrease in [matrix metalloproteinase (MMP)] expression and activity , concomitant with increases in tissue inhibitor of metalloproteinase ( TIMP ) 1 and E-cadherin expression within tumors . Negative_regulation MMP7 CD44 19644051 2138226 Hypoxia induced mRNA expression of the beta-catenin associated genes : MMP-7 , , and c-Myc. RNAi of TCF7L2 , a cofactor of beta-catenin , *suppressed* [MMP-7] expression induced by hypoxia . Negative_regulation MMP7 CDC73 23911909 2840279 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Negative_regulation MMP7 CDH1 12875984 1115262 *mediates* [MMP] down-regulation in highly invasive bronchial tumor cells . Negative_regulation MMP7 CORT 11930228 894609 The disruption of [MMP] was *induced* by ( 10 ( 6 ) mol/L ) in hippocampal neurons cultured in hypoglycemic and serum free medium and antagonized by high concentration of glucose . Negative_regulation MMP7 CORT 11930228 894631 *induced* reduction of [MMP] may be one of the mechanisms for its neurotoxicity . Negative_regulation MMP7 CPZ 23368734 2739066 This study identified cytotoxicity and *inhibition* of mitochondrial [membrane potential (MMP)] to be concentration dependent . Negative_regulation MMP7 CRIP1 17714826 1816940 It has been reported that an endogenous [matrix metalloproteinase (MMP)] inhibitor , reversion *inducing* with Kazal motifs ( RECK ) , is able to inhibit tumour angiogenesis , invasion , and metastasis through inhibition of MMP-2 , MMP-9 , and membrane type-1 (MT1)-MMP ( MMP-14 ) secretion and activity . Negative_regulation MMP7 CRIP1 24812324 2944895 Mechanistically , miR-712 stimulated MMP activity in the aortic wall by directly targeting 2 [MMP] inhibitors : tissue inhibitor of metalloproteinase 3 ( TIMP3 ) and reversion *inducing* with kazal motifs ( RECK ) . Negative_regulation MMP7 CRIP2 17714826 1816941 It has been reported that an endogenous [matrix metalloproteinase (MMP)] inhibitor , reversion *inducing* with Kazal motifs ( RECK ) , is able to inhibit tumour angiogenesis , invasion , and metastasis through inhibition of MMP-2 , MMP-9 , and membrane type-1 (MT1)-MMP ( MMP-14 ) secretion and activity . Negative_regulation MMP7 CRIP2 24812324 2944896 Mechanistically , miR-712 stimulated MMP activity in the aortic wall by directly targeting 2 [MMP] inhibitors : tissue inhibitor of metalloproteinase 3 ( TIMP3 ) and reversion *inducing* with kazal motifs ( RECK ) . Negative_regulation MMP7 CRIP3 17714826 1816939 It has been reported that an endogenous [matrix metalloproteinase (MMP)] inhibitor , reversion *inducing* with Kazal motifs ( RECK ) , is able to inhibit tumour angiogenesis , invasion , and metastasis through inhibition of MMP-2 , MMP-9 , and membrane type-1 (MT1)-MMP ( MMP-14 ) secretion and activity . Negative_regulation MMP7 CRIP3 24812324 2944894 Mechanistically , miR-712 stimulated MMP activity in the aortic wall by directly targeting 2 [MMP] inhibitors : tissue inhibitor of metalloproteinase 3 ( TIMP3 ) and reversion *inducing* with kazal motifs ( RECK ) . Negative_regulation MMP7 CSE 21850498 2574387 We further observed that the levels of IL1ß induced MMP-1 , MMP-3 , [MMP-7] , and MMP-9 mRNA , but not TIMP mRNA levels , were down-regulated in chondrocytes in *response* to . Negative_regulation MMP7 CTR9 23911909 2840280 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Negative_regulation MMP7 CXCL9 11304581 803748 Migration on Ln-5 is blocked by BB-94 , an [MMP] *inhibitor* , and by , a monoclonal antibody that hinders migration on MMP-2 cleaved Ln-5 . Negative_regulation MMP7 CYBB 24624929 2934207 Increased cardiomyocyte hypertrophy and myocardial fibrosis in response to pressure overload correlated with increased oxidative stress , and loss of prevented the increase in oxidative stress , development of cardiomyocyte hypertrophy , myocardial fibrosis and *increased* myocardial [MMP] ( matrix metalloproteinase ) activity in response to pressure overload . Negative_regulation MMP7 CYCS 11067917 747125 Overexpression of B cell lymphoma gene 2 (Bcl-2) *inhibited* TRAIL induced release of , changes in [MMP] , and apoptosis . Negative_regulation MMP7 ECE1 16323056 1488029 The mRNA levels of preproET-1 , endothelin converting enzyme ( ) , ETa receptor and ETb receptor , matrix metalloproteinase ( MMP-2 ) , tissue *inhibitor* of [MMP] ( TIMP-2 ) , and heat shock protein ( HSP-70 ) were determined by quantitative real-time RT-PCR . Negative_regulation MMP7 ELANE 18492178 1497386 inhibition of activity to *prevent* extracellular matrix damage and activation of matrix metalloproteases ( MMPs ) , and inhibition of [MMP] expression ( e.g. by retinoids ) and activity ( e.g. by natural and synthetic inhibitors ) . Negative_regulation MMP7 ERBB2 18851945 1988683 The expression of [matrix metalloproteinase (MMP)] genes was *enhanced* by the overexpression of . Negative_regulation MMP7 ERBB2 19457660 2090894 Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent [MMP] selectivity and sheddase *inhibition* . Negative_regulation MMP7 ETS1 18851945 1988684 The expression of [matrix metalloproteinase (MMP)] genes was *enhanced* by the overexpression of . Negative_regulation MMP7 FAS 11980895 954091 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of [MMP] and cytochrome c release . Negative_regulation MMP7 FGF2 15363819 1294003 Augmented levels may *contribute* to parallel decreases in [MMP] activity and MMP induction system resulting in enhanced collagen deposition in hypertension . Negative_regulation MMP7 GP2 19208844 2039364 RECK , a glycosylphosphatidylinositol anchored , *inhibits* the enzymatic activities of some [matrix metalloproteinases (MMP)] , thereby suppressing tumor cell metastasis ; Negative_regulation MMP7 GP5 19208844 2039365 RECK , a glycosylphosphatidylinositol anchored , *inhibits* the enzymatic activities of some [matrix metalloproteinases (MMP)] , thereby suppressing tumor cell metastasis ; Negative_regulation MMP7 GP6 19208844 2039363 RECK , a glycosylphosphatidylinositol anchored , *inhibits* the enzymatic activities of some [matrix metalloproteinases (MMP)] , thereby suppressing tumor cell metastasis ; Negative_regulation MMP7 GP9 19208844 2039366 RECK , a glycosylphosphatidylinositol anchored , *inhibits* the enzymatic activities of some [matrix metalloproteinases (MMP)] , thereby suppressing tumor cell metastasis ; Negative_regulation MMP7 HAND2 20627079 2291855 Loss of function *causes* reduced [MMP] activity and prolonged laminin deposition at the LPM/gut boundary , leading to failed asymmetric LPM migration and gut looping . Negative_regulation MMP7 HBEGF 17322418 1747792 Inhibition of heparin binding EGF-like growth factor ( ) release by CRM-197 and *inhibition* of [matrix metalloproteinases (MMP)] by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation . Negative_regulation MMP7 HDAC4 20847282 2325719 Furthermore , ectopic expression of in quiescent HSCs *results* in repression of [MMP] promoter activities as well as endogenous MMP9 protein expression . Negative_regulation MMP7 HPR 21723035 2460993 TMEM14A prevented <4-HPR> *induced* loss of mitochondrial [membrane potential (MMP)] , the release of cytochrome c , and the activation of caspase-3 , but not the generation of reactive oxygen species , suggesting that TMEM14A regulates mitochondrial membrane potential in a ROS independent manner . Negative_regulation MMP7 HPR 21723035 2461085 As expected , cyclosporin A , an inhibitor of membrane potential transition , inhibited <4-HPR> *induced* loss of [MMP] and apoptosis in U87MG cells , indicating that loss of MMP plays a pivotal role in 4-HPR induced apoptosis . Negative_regulation MMP7 IFNG 18802113 1964628 , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly *suppressed* TLR induced [MMP] expression . Negative_regulation MMP7 IGF1 19493905 2108220 *reduced* the expression of these MMPs but especially [matrilysin] ( MMP-7 ) . Negative_regulation MMP7 IGF1 19493905 2108222 Insulin-like growth factor (IGF) stimulated secretion of matrilysin and *blocked* IGF mediated [matrilysin] induction in three GI cancers . Negative_regulation MMP7 IGF2 19493905 2108221 *reduced* the expression of these MMPs but especially [matrilysin] ( MMP-7 ) . Negative_regulation MMP7 IGF2 19493905 2108223 Insulin-like growth factor (IGF) stimulated secretion of matrilysin and *blocked* IGF mediated [matrilysin] induction in three GI cancers . Negative_regulation MMP7 IL10 9561025 477866 However may *inhibit* the production of [matrix metalloproteases (MMP)] and prevent the establishment of metastasis . Negative_regulation MMP7 IL1A 18975039 2059509 In the *presence* of , the broad-spectrum MMP inhibitor GM 6001 decreased the [MMP] activity in the media , increased the shear strength of repair , and enhanced tissue repair in the interface . Negative_regulation MMP7 IL1A 22415590 2686483 Stimulation of cells with only *resulted* in an overexpression of [MMP] and their TIMP mRNAs . Negative_regulation MMP7 IL1B 16122880 1461095 A dose dependent inhibition of and TPA *stimulated* [MMP] activity by gallium nitrate at increasing concentrations occurs , demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis . Negative_regulation MMP7 IL2 20921282 2337537 Furthermore , *induced* the IFN-?- and NO-dependent decrease in [matrix metalloproteinase (MMP)] expression and activity , concomitant with increases in tissue inhibitor of metalloproteinase ( TIMP ) 1 and E-cadherin expression within tumors . Negative_regulation MMP7 IL21R 16682426 1645828 IBD LPMC supernatants stimulate [MMP] secretion by intestinal fibroblasts , and this effect is partly *inhibited* by . Negative_regulation MMP7 IL6 17339835 1720161 A *role* for in the regulation of metalloproteinase ( [MMP)-7] expression by CORM-2 is described . Negative_regulation MMP7 IL6 8515078 222031 The results suggest that OM as well as and LIF , other cytokines acting through similar receptor pathways , may act to *inhibit* net [MMP] activity by specifically up-regulating TIMP-1 expression . Negative_regulation MMP7 ISL1 19157825 2182305 dose-dependently *suppressed* PMA induced expression and activity of MMP-2 and membrane type [1-MMP] at > or=1 microM while diminishing the elevated MMP-2 transcript level . Negative_regulation MMP7 ISL1 19157825 2182354 Therefore , the *inhibition* of [MMP] may boost a therapeutic efficacy during angiogenesis . Negative_regulation MMP7 ISL2 19157825 2182304 dose-dependently *suppressed* PMA induced expression and activity of MMP-2 and membrane type [1-MMP] at > or=1 microM while diminishing the elevated MMP-2 transcript level . Negative_regulation MMP7 ISL2 19157825 2182353 Therefore , the *inhibition* of [MMP] may boost a therapeutic efficacy during angiogenesis . Negative_regulation MMP7 JUN 12958188 1138254 Conversely , the dominant negative mutant TAM67 and the src tyrosine kinase inhibitor M475271 *impaired* src induced Mp activation , [matrilysin] protein accumulation , and invasion of type I collagen gels . Negative_regulation MMP7 LCN1 8922288 397108 When the complex *inhibits* an [MMP] , a quaternary complex monomer/lipocalin/TIMP-1/MMP is generated which after activation shows a sixfold higher proteolytic activity than the active ternary complex . Negative_regulation MMP7 LCN10 8922288 397104 When the complex *inhibits* an [MMP] , a quaternary complex monomer/lipocalin/TIMP-1/MMP is generated which after activation shows a sixfold higher proteolytic activity than the active ternary complex . Negative_regulation MMP7 LCN12 8922288 397106 When the complex *inhibits* an [MMP] , a quaternary complex monomer/lipocalin/TIMP-1/MMP is generated which after activation shows a sixfold higher proteolytic activity than the active ternary complex . Negative_regulation MMP7 LCN15 8922288 397107 When the complex *inhibits* an [MMP] , a quaternary complex monomer/lipocalin/TIMP-1/MMP is generated which after activation shows a sixfold higher proteolytic activity than the active ternary complex . Negative_regulation MMP7 LCN2 8922288 397109 When the complex *inhibits* an [MMP] , a quaternary complex monomer/lipocalin/TIMP-1/MMP is generated which after activation shows a sixfold higher proteolytic activity than the active ternary complex . Negative_regulation MMP7 LCN6 8922288 397102 When the complex *inhibits* an [MMP] , a quaternary complex monomer/lipocalin/TIMP-1/MMP is generated which after activation shows a sixfold higher proteolytic activity than the active ternary complex . Negative_regulation MMP7 LCN8 8922288 397105 When the complex *inhibits* an [MMP] , a quaternary complex monomer/lipocalin/TIMP-1/MMP is generated which after activation shows a sixfold higher proteolytic activity than the active ternary complex . Negative_regulation MMP7 LCN9 8922288 397103 When the complex *inhibits* an [MMP] , a quaternary complex monomer/lipocalin/TIMP-1/MMP is generated which after activation shows a sixfold higher proteolytic activity than the active ternary complex . Negative_regulation MMP7 LEF1 15457508 1304915 Expression of the T-cell factor , , enhances transcriptional activation of the human MMP-7 promoter by beta-catenin , but *represses* activation of the mouse [MMP-7] promoter , both activities through consensus Tcf binding sites . Negative_regulation MMP7 LEF1 22686279 2615556 Thus , a decrease of expression using LEF-1 siRNA *resulted* in down-regulation of cyclin D and [MMP-7] expression , respectively . Negative_regulation MMP7 LEF1 22686279 2615558 Taken together , our results indicate a pivotal *role* of in the regulation of proliferation and [MMP-7] transcription in breast cancer cells . Negative_regulation MMP7 LEO1 23911909 2840283 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Negative_regulation MMP7 LIF 8515078 222032 The results suggest that OM as well as IL-6 and , other cytokines acting through similar receptor pathways , may act to *inhibit* net [MMP] activity by specifically up-regulating TIMP-1 expression . Negative_regulation MMP7 LMNA 16764831 1585502 [MMP] was hyperpolarized after 30OGD ( 1.26 +/- 0.23 ( vehicle ) , 1.29 +/- 0.13 ( Pro0.1 ) and 1.18 +/- 0.06 ( Pro1.0 ) ) but was depolarized after 90OGD ( 0.77 +/- 0.04 ( vehicle ) , 0.89 +/- 0.04 ( Pro0.1 ) , but .0 *prevented* depolarization ( 1.03 +/- 0.15 ( P < 0.05 ) ) . Negative_regulation MMP7 MAP3K7 23962703 2909775 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , mitogen activated protein kinases (MAPK) : mitogen activated protein kinase kinase kinase 7 ( ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP7 MAPK1 23962703 2909776 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP7 MAPK10 23962703 2909777 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP7 MAPK11 23962703 2909778 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP7 MAPK12 23962703 2909779 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP7 MAPK13 23962703 2909780 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP7 MAPK14 23962703 2909781 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP7 MAPK15 23962703 2909774 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP7 MAPK3 21999204 2547395 The expression of [MMP-7] and the migrating ability of MSLN treated ovarian cancer cells were *suppressed* by or JNK-specific inhibitors , or a decoy AP-1 ( activator protein 1 ) oligonucleotide in in vitro experiments , whereas in vivo animal experiments also demonstrated that mice treated with MAPK ( mitogen activated protein kinase ) /ERK- or JNK-specific inhibitors could decrease intratumour MMP-7 expression , delay tumour growth and extend the survival of the mice . Negative_regulation MMP7 MAPK3 23962703 2909782 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP7 MAPK4 23962703 2909783 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP7 MAPK6 23962703 2909784 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP7 MAPK7 23962703 2909785 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP7 MAPK8 23962703 2909786 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP7 MAPK9 23962703 2909787 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , : mitogen activated protein kinase kinase kinase 7 ( TAK1 ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP7 MIF 16872482 1663451 In the present study , we determined the *role* of in RA synovial fibroblast [MMP] production and the underlying signaling mechanisms . Negative_regulation MMP7 MMP1 11522015 852659 The concentrations of t-PA , PAI-1 , collagenase ( ) , tissue *inhibitor* of [MMP] ( TIMP-1 ) , plasmin-antiplasmin (PAP) complexes and alpha2-macroglobulin (alpha2-M) were measured in plasma samples . Negative_regulation MMP7 MMP1 11730752 885000 To assess the presence of matrix metalloproteinase ( ) and tissue *inhibitor* of [MMP] ( TIMP-1 ) in peritoneal fluid and serum of subjects with and without adhesions . Negative_regulation MMP7 MMP1 11817102 888002 In conclusion , these findings suggest that the activity of MMPs may bealtered by downregulation and *inhibition* of [MMP] activity by PAl-1 and TIMP-1 generated from tubular epithelial cells . Negative_regulation MMP7 MMP12 19513084 2128554 To assess the functions of MMPs in flow induced outward vascular remodeling , we used doxycycline ( broad-spectrum [MMP] *inhibitor* ) , SB-3CT ( selective MMP inhibitor ) , MMP-9 knockout mice , and knockout mice . Negative_regulation MMP7 MMP13 10415735 631378 We studied AG3340 , a potent metalloproteinase ( [MMP] ) *inhibitor* with pM affinities for inhibiting gelatinases ( MMP-2 and -9 ) , MT-MMP-1 ( MMP-14 ) , and collagenase-3 ( ) in many tumor models . Negative_regulation MMP7 MMP13 10537164 563102 In this study , we have examined the physiological regulation pattern and cellular distribution of messenger RNAs coding for gelatinase A ( MMP-2 ) , collagenase-3 ( ) , membrane type MMP 1 ( MT1-MMP , MMP-14 ) , and the major [MMP] *inhibitor* , tissue inhibitor of MMPs type 1 (TIMP-1) in the CL of adult pseudopregnant (psp) rat . Negative_regulation MMP7 MMP14 10415735 631379 We studied AG3340 , a potent metalloproteinase ( [MMP] ) *inhibitor* with pM affinities for inhibiting gelatinases ( MMP-2 and -9 ) , MT-MMP-1 ( ) , and collagenase-3 ( MMP-13 ) in many tumor models . Negative_regulation MMP7 MMP14 20000122 2174820 The aim of this study was to elucidate peculiarity of expression of gelatinases A and B ( MMP-2 and MMP-9 ) , membrane type MMP ( ) and tissue *inhibitor* of [MMP] ( TIMP-2 ) in immortal ( IF ) and transformed fibroblasts ( TF ) . Negative_regulation MMP7 MMP16 11891989 920563 We cloned two new Xenopus MMPs , gelatinase A ( MMP-2 ) and MT3-MMP ( ) , and the [MMP] *inhibitor* TIMP-2 . Negative_regulation MMP7 MMP17 24098510 2852273 Morpholino inactivation of function , or chemical *inhibition* of [MMP] activity results in aberrant NC cell migration with minimal change in NC proliferation or apoptosis . Negative_regulation MMP7 MMP2 10537164 563103 In this study , we have examined the physiological regulation pattern and cellular distribution of messenger RNAs coding for gelatinase A ( ) , collagenase-3 ( MMP-13 ) , membrane type MMP 1 ( MT1-MMP , MMP-14 ) , and the major [MMP] *inhibitor* , tissue inhibitor of MMPs type 1 (TIMP-1) in the CL of adult pseudopregnant (psp) rat . Negative_regulation MMP7 MMP2 11891989 920564 We cloned two new Xenopus MMPs , gelatinase A ( ) and MT3-MMP ( MMP-16 ) , and the [MMP] *inhibitor* TIMP-2 . Negative_regulation MMP7 MMP2 17604018 1779669 Treatment with bafilomycin A1 , an activator , or GM6001 , an [MMP] *inhibitor* , at the pre-condensation stage resulted in the inhibition or promotion of chondrogenesis , respectively . Negative_regulation MMP7 MMP2 22042083 2540107 This effect may be partially mediated by increased and TIMP activities in the aortic wall and *reduced* TNFa stimulated inflammation and [MMP] activation in macrophages . Negative_regulation MMP7 MMP2 22251575 2605744 In conclusion , non-toxic levels of alendronate ( 10 ( -8 ) to 10 ( -6 ) M ) did not alter [MMP] expression in MG63 cells or *inhibit* activity . Negative_regulation MMP7 MMP9 22742512 2691627 We also investigated the capacity of these compounds to reduce cytokine and [matrix metalloproteinase (MMP)] secretion by lipopolysaccharide (LPS) stimulated macrophages and to *inhibit* activity . Negative_regulation MMP7 MTOR 22449440 2582967 Furthermore , it was found that *caused* a loss of mitochondrial [membrane potential (MMP)] and the release of cytochrome c to the cytosol . Negative_regulation MMP7 MUC5AC 23801416 2885184 Silencing of by using a small hairpin RNA containing lentivirus *increased* the invasion and migration of SNU216 and AGS cells as well as Akt phosphorylation and the expression of vascular endothelial growth factor and [matrix metalloproteinase-7] , which were blocked by inhibitors of the phosphatidylinositol 3-kinase/Akt pathway . Negative_regulation MMP7 NA 13677383 1140084 We documented that EDTA , doxycycline , , ilomostat , alpha1PI , and ES *inhibited* [MMP] activity in vitro . Negative_regulation MMP7 NA 20651358 2293199 *reduced* the number of annexin V-positive cells and [MMP] ( Delta Psi ( m ) ) loss by MG132 . Negative_regulation MMP7 NA 20674558 2311744 DP increased the levels of reactive oxygen species ( ROS ) in HepG2 cells , and antioxidant completely blocked DP-induced ROS accumulation and the disruption of the balance between Bax and Bcl-2 proteins , and effectively *blocked* the decreased [MMP] and apoptosis , but had no effect on the activation of caspase-8 and the up-regulations of DR4 and DR5 induced by DP . Negative_regulation MMP7 NEU1 19151752 2043160 Moreover , *caused* downregulation of [matrix metalloproteinase-7] , overexpression of which is associated with cancer metastasis . Negative_regulation MMP7 NFKB1 20188213 2236925 Additionally , by altering transcription activity in FLSs , curcumin *inhibited* PGE ( 2 ) production , COX-2 expression , and [MMP] secretion . Negative_regulation MMP7 NFKBIA 12006388 940117 Human macrophages and rabbit foam cells secreted [matrix degrading metalloproteinase (MMP)-9] without further stimulation , and this was not *inhibited* by ( 11+/-16 % and 8+/-10 % , respectively ; Negative_regulation MMP7 NOS1 11971672 933642 This study tested the hypothesis that inhibition in whole aortic wall *causes* increases in cytokine stimulated [MMP] and TIMP expression . Negative_regulation MMP7 NOX1 17543193 1668493 The endothelial cell NADPH oxidase and endothelial cell [MMP] activities are *required* for VCAM-1 dependent lymphocyte migration as determined by scavenging of ROS , by pharmacologic or antisense inhibition of and by pharmacologic inhibition of endothelial cell MMPs . Negative_regulation MMP7 NOX3 17543193 1668494 The endothelial cell NADPH oxidase and endothelial cell [MMP] activities are *required* for VCAM-1 dependent lymphocyte migration as determined by scavenging of ROS , by pharmacologic or antisense inhibition of and by pharmacologic inhibition of endothelial cell MMPs . Negative_regulation MMP7 NOX4 17543193 1668495 The endothelial cell NADPH oxidase and endothelial cell [MMP] activities are *required* for VCAM-1 dependent lymphocyte migration as determined by scavenging of ROS , by pharmacologic or antisense inhibition of and by pharmacologic inhibition of endothelial cell MMPs . Negative_regulation MMP7 NOX5 17543193 1668492 The endothelial cell NADPH oxidase and endothelial cell [MMP] activities are *required* for VCAM-1 dependent lymphocyte migration as determined by scavenging of ROS , by pharmacologic or antisense inhibition of and by pharmacologic inhibition of endothelial cell MMPs . Negative_regulation MMP7 OSM 17469134 1737497 and TNF stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP7 PAF1 23911909 2840281 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Negative_regulation MMP7 PAK1 22416254 2612599 To investigate the *role* of in regulating migration , invasion and [MMP] expression in RA fibroblast-like synoviocytes ( FLS ) . Negative_regulation MMP7 PAK1 23744893 2807144 Together , these data illustrate the complex interaction between the substratum and PRL/PAK1 signaling in human breast cancer cells and suggest a pivotal *role* for PRL dependent tyrosyl phosphorylation in [MMP] secretion . Negative_regulation MMP7 PARK7 22687481 2611755 Mitochondrial [membrane potential (MMP)] was decreased in MDA-MB-435 cells by BCA , and overexpression *inhibited* BCA induced MMP decrease in these cells . Negative_regulation MMP7 PDGFB 17099219 1676234 *inhibited* the synthesis and secretion of all hypoxia dependent [MMP] via Erk1/2 mitogen activated protein (MAP) kinase activation . Negative_regulation MMP7 PDLIM7 17913445 1812859 To investigate the *role* of in [MMP] expression in NPC , we cloned the LMP1 gene from NPC samples and transiently expressed it in MRC5 cells ( human lung fibroblasts ) . Negative_regulation MMP7 PIK3CA 16142341 1451187 Inhibition of signaling in LM8 by a PI3K inhibitor , LY294002 , or by a dominant negative form of Akt , *resulted* in suppression of [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Negative_regulation MMP7 PIK3R1 16142341 1451188 Inhibition of signaling in LM8 by a PI3K inhibitor , LY294002 , or by a dominant negative form of Akt , *resulted* in suppression of [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Negative_regulation MMP7 PLAT 22244977 2564148 We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle , delayed alone , or combined tPA ( 10 mg/kg , i.v. ) plus GM6001 ( 100 mg/kg , i.p. ) , a broad-spectrum [MMP] *inhibitor* . Negative_regulation MMP7 PLAU 12117412 997467 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Negative_regulation MMP7 PLAU 24418973 2942389 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 in the conditioned media . Negative_regulation MMP7 PLAUR 18548111 1984149 In conclusion , this study suggests that the absence of not only *regulates* fibrosis related gene expression and [MMP] activity but also results in ECM deposition . Negative_regulation MMP7 PLAUR 18987331 2022006 Interleukin 11 ( 100 ng/ml ) had no effect on matrix metallopeptidases 2 and 9 ( MMP2 and MMP9 ) , tissue *inhibitors* of [MMP] ( TIMP1 , TIMP2 , and TIMP3 ) , plasminogen activator urokinase (PLAU) , plasminogen activator urokinase receptor ( ) , and serpin peptidase inhibitors 1 and 2 ( SERPINE1 and SERPINE2 ) in EVT conditioned media and/or cell lysates . Negative_regulation MMP7 PLG 17574041 1754364 Migration assays were performed in the presence of K with and without the inhibitors ( aprotinin and -aminocaproic acid ) , the Galphai inhibitor Pertussis toxin , the [MMP] inhibitor ( GM6001 ) , the PI3-K inhibitors , Wortmannin and LY294002 , and the MAPK inhibitors PD98089 ( MEK1 inhibitor ) and SB203580 ( p38 ( MAPK ) *inhibitor* ) . Negative_regulation MMP7 PMS1 23902346 2840049 Collectively , these results suggest that quercetin inhibits cell motility via the inhibition of [MMP] activation in HT1080 cells in the *presence* and absence of . Negative_regulation MMP7 PMS2 23902346 2840050 Collectively , these results suggest that quercetin inhibits cell motility via the inhibition of [MMP] activation in HT1080 cells in the *presence* and absence of . Negative_regulation MMP7 PPARG 14742672 1203491 Here , we test the hypothesis that CDDO and 15-dPGJ2 use to *repress* [MMP] gene expression . Negative_regulation MMP7 PRDX2 23575963 2804317 All of the HDAC inhibitors prevented degradation of BNC , in which and MS-275 *repressed* cytokine induced [MMP] expression . Negative_regulation MMP7 RAPGEF1 10811109 692984 In contrast , expression of dominant negative did not *suppress* [MMP] secretion , although it substantially blocked the c-Jun N-terminal kinase activation . Negative_regulation MMP7 RB1 23258984 2709133 Among the GSs , most effectively *inhibited* [MMP] activity . Negative_regulation MMP7 RECK 12447698 1018184 In this study , we test the possibility that NSAIDs may up-regulate to *inhibit* [MMP] activity . Negative_regulation MMP7 RECK 12810630 1102722 In this study , we test the possibility that HDAC inhibitor may increase expression to *inhibit* [MMP] activation and cancer cell invasion . Negative_regulation MMP7 RECK 15604273 1346879 TIMP-2 and Ala+TIMP-2 also suppress basal hMVEC migration via a time dependent mechanism mediated by enhanced expression of , a membrane anchored [MMP] *inhibitor* , which , in turn , inhibits cell migration . Negative_regulation MMP7 RECK 16491114 1581808 We previously demonstrated that TIMP-2 increases the association of Crk with C3G and via subsequent activation of Rap1 enhances the expression of , a membrane anchored [MMP] *inhibitor* . Negative_regulation MMP7 RECK 18300271 1912004 Here , we examined the expression of , a novel membrane anchored [MMP] *inhibitor* , in PSCs . Negative_regulation MMP7 RECK 19270735 2045687 We silenced expression of three insect-type Tribolium [MMP] paralogs and their physiological *inhibitors* , TIMP and , by dsRNA mediated genetic interference ( RNAi ) . Negative_regulation MMP7 RECK 22227894 2605490 TIMP-2 , the most studied member of the family , can both inhibit and activate MMPs directly , as well as *inhibit* [MMP] activity indirectly by upregulating expression of , a membrane anchored MMP regulator . Negative_regulation MMP7 RECK 22260435 2551315 Matrix metalloproteinases ( MMPs ) and their inhibitors , known as tissue inhibitors of MMPs ( TIMPs ) , and the membrane associated [MMP] *inhibitor* ( ) , are essential for the metastatic process . Negative_regulation MMP7 REG1A 23516491 2761615 Furthermore , the results also revealed that the opening of MPTPs and the loss of [MMP] induced by azadirachtin could be significantly *inhibited* by the inhibitor cyclosporin A ( CsA ) , which was used to identify the key role of mitochondria in the apoptosis of Sf9 cells . Negative_regulation MMP7 RELA 20188213 2236926 Additionally , by altering transcription activity in FLSs , curcumin *inhibited* PGE ( 2 ) production , COX-2 expression , and [MMP] secretion . Negative_regulation MMP7 RETN 21277149 2403303 Furthermore , activated PKCe , but selective PKCe inhibitor *suppressed* resistin induced [MMP] expression , activity , and cell migration . Negative_regulation MMP7 RLN1 16709614 1584630 Taken together , this study provides proof-of- principle that gene expression targeted to the mouse lungs can *result* in enhanced [MMP] activity offering potential for alleviating disease conditions characterized by dysregulation of extracellular matrix protein accumulation . Negative_regulation MMP7 RLN2 16709614 1584631 Taken together , this study provides proof-of- principle that gene expression targeted to the mouse lungs can *result* in enhanced [MMP] activity offering potential for alleviating disease conditions characterized by dysregulation of extracellular matrix protein accumulation . Negative_regulation MMP7 RLN3 16709614 1584632 Taken together , this study provides proof-of- principle that gene expression targeted to the mouse lungs can *result* in enhanced [MMP] activity offering potential for alleviating disease conditions characterized by dysregulation of extracellular matrix protein accumulation . Negative_regulation MMP7 SARS 16127601 655742 The opening session was chaired by Stanislaw Pikul ( Procter and Gamble Co , OH , USA ) and included talks covering aspects of the syntheses and of corticotropin releasing hormone antagonists , serine proteinase , [matrix metalloproteinase (MMP)] and cysteine proteinase *inhibitors* . Negative_regulation MMP7 SERPINA1 18250185 1924652 These findings suggest a novel role for *inhibition* of NE-induced upregulation of [MMP] and cathepsin expression both in vitro and in vivo . Negative_regulation MMP7 SERPINE1 17156777 1694136 MGF-Ct24E peptide *enhances* the expression of u-PA , u-PAR and [MMP-7] while reducing activity . Negative_regulation MMP7 SERPINE1 21465481 2523787 During wound healing , elevated levels of *inhibit* uPA/tPA/plasmin and plasmin dependent [MMP] activities , and , thus , help expedite wound healing . Negative_regulation MMP7 SIRT1 20426787 2315412 We examined if is *involved* in the regulation of [matrix metalloproteinase (MMP)] expression in human dermal fibroblasts . Negative_regulation MMP7 SNAP25 21395558 2447973 ( S-nitroso-N-acetylpenicillamine ) , a NO ( nitric oxide ) donor , and 8-Br-cGMP ( 8-bromo-cGMP ) *inhibited* thapsigargin induced Ca2+ entry and [MMP] secretion in the invasive potential of human SMMC-7721 cells . Negative_regulation MMP7 SNAP25 21437907 2523583 MPs lacked the MMP inhibitors TIMP-1 and TIMP-2 found in the Sup and , while strongly *inhibited* [MMP] activities but MPs did not . Negative_regulation MMP7 SP1 20488920 2288808 CDDO-Me also induced reactive oxygen species ( ROS ) and decreased mitochondrial membrane potential (MMP) in Panc1 and L3.6pL cells , and cotreatment with antioxidants ( glutathione and dithiothreitol ) blocked the formation of ROS , reversed the loss of [MMP] , and *inhibited* down-regulation of , Sp3 , and Sp4 . Negative_regulation MMP7 SPN 19491303 2102903 was found to *inhibit* [MMP] production in pro-inflammatory cytokine stimulated chondrocytes . Negative_regulation MMP7 STAT1 17875686 1796178 Despite the fact that silencing of was not *sufficient* to alter the [MMP] , STAT1 deficiency , like Ras mutations , sensitized cells to apoptosis induced by HDACi . Negative_regulation MMP7 TAB1 23962703 2909773 The effect of ZEA on pro-inflammatory ( TNF-a , IL-8 , IL-6 , IL-1ß and interferon-? ) and anti-inflammatory ( IL-10 and IL-4 ) cytokines and other molecules involved in inflammatory processes ( [matrix metalloproteinases (MMP)/tissue] *inhibitors* of matrix metalloproteinases ( TIMP ) , nuclear receptors : PPAR? and NF-?B1 , mitogen activated protein kinases (MAPK) : mitogen activated protein kinase kinase kinase 7 ( ) /mitogen activated protein kinase 14 ( p38a ) /mitogen activated protein kinase 8 ( JNK1 ) / mitogen activated protein kinase 9 ( JNK2 ) ) in the liver of piglets was investigated . Negative_regulation MMP7 TCF7L2 23603903 2800145 Overexpression of , but not of TCF3 or LEF1 , *induced* MMP-1 , -3 , and -13 expression and generic [MMP] activity in human chondrocytes . Negative_regulation MMP7 TFPI2 20015200 2489013 Moreover , down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in a ( 1 ) integrin on cell surface , and *increased* [MMP] expression ( mainly MMP-1 and -3 ) contributing to cancer cell invasion through basement membrane components . Negative_regulation MMP7 TGFB1 10390144 626183 [MMP] activity can be *down-regulated* by ( TGF-beta1 ) , a growth modulating factor , found in high concentrations in the bone . Negative_regulation MMP7 TGFB1 15247230 1289652 Because transforming growth factor-beta1 ( TGF-beta1 ) promotes tumor invasion in advanced squamous cell carcinomas , the *role* of in the regulation of [MMP] activity in a cellular model of invasive oral squamous cell carcinoma was examined . Negative_regulation MMP7 TGFB1 16236725 1476803 Furthermore , exogenous potentially rescued emphysema-like phenotype and concomitantly *reduced* [MMP] expression in Fut8 ( -/- ) lung . Negative_regulation MMP7 THBS1 10900205 736875 Tissue culture and in vitro assays demonstrated that the presence of purified TSR and intact resulted in *inhibition* of [MMP] activity . Negative_regulation MMP7 THBS1 17266545 1691510 In addition , mediated *inhibition* of [MMP] activity may decrease adverse remodeling . Negative_regulation MMP7 THBS1 22798012 2645647 This effect resulted from the presence of the potent [MMP] *inhibitors* , tissue inhibitor of metalloproteinases-1 ( TIMP-1 ) , type-1 plasminogen activator inhibitor ( PAI-1 ) and in the amnion dressings , as shown by real-time fluorescence zymography and protein microarrays . Negative_regulation MMP7 THBS2 21479427 2009774 In this study , we examined the *role* of in tumor cell invasion and its association with proteolytic proteins , [matrix metalloproteinase (MMP)] and the plasminogen/plasmin system , including urokinase-type plasminogen activator ( uPA ) , in the human pancreatic cancer cell line PANC-1 . Negative_regulation MMP7 TIMP1 10207248 561206 Functional and immunochemical approaches were used to assess [matrix metalloproteinase (MMP)] *inhibitors* , e.g. , and 2 ( TIMP-1 and TIMP-2 ) , in organ cultures of normal human skin maintained under growth factor free conditions or in medium supplemented with a combination of growth factors including epidermal growth factor , insulin , and pituitary extract . Negative_regulation MMP7 TIMP1 10330038 614051 We analyzed 1 ) collagen metabolism by [ 3H ] proline incorporation , 2 ) [matrix metalloproteinase (MMP)] expression by substrate gel zymography , and 3 ) tissue *inhibitor* of metalloproteinases ( ) expression by Western blot analysis . Negative_regulation MMP7 TIMP1 10430768 633622 To define the role of metalloproteinases ( MMPs ) in the development of lipid-rich atherosclerotic lesions in relation to the balance between proteolytic and antiproteolytic activities , we investigated the impact of adenovirus mediated elevation in the circulating levels of human tissue *inhibitor* of [MMP] ( ) in atherosclerosis-susceptible apolipoprotein E-deficient ( apoE ( -/- ) ) mice . Negative_regulation MMP7 TIMP1 10537164 563101 In this study , we have examined the physiological regulation pattern and cellular distribution of messenger RNAs coding for gelatinase A ( MMP-2 ) , collagenase-3 ( MMP-13 ) , membrane type MMP 1 ( MT1-MMP , MMP-14 ) , and the major [MMP] *inhibitor* , in the CL of adult pseudopregnant (psp) rat . Negative_regulation MMP7 TIMP1 10851028 701547 Data on changes in mRNA expression for the [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) in various forms of diabetic nephropathy are presented . Negative_regulation MMP7 TIMP1 10914842 716566 The findings indicate that estrogen exerts a stimulatory effect , while progesterone has an inhibitory effect on the expression of MMP , their tissue *inhibitors* ( ) , and enzymatic activity of [MMP] produced by these cells . Negative_regulation MMP7 TIMP1 11261483 764408 Tumour invasion and trophoblastic invasion share the same biochemical mediators : the [matrix metalloproteinases (MMP)] and their *inhibitors* ( ) . Negative_regulation MMP7 TIMP1 11274326 797634 The authors quantitatively measured levels of [matrix metalloproteinases (MMP)] , tissue *inhibitor* of metalloproteinases ( ) , and vascular endothelial growth factor ( VEGF ) in blood samples of POEMS syndrome . Negative_regulation MMP7 TIMP1 11279294 798545 Mammalian ovaries express a number of [matrix metalloproteinases (MMP)] and their tissue *inhibitors* ( ) . Negative_regulation MMP7 TIMP1 11420387 830612 [Matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) are major regulators of tissue remodelling of the extracellular matrix (ECM) and may also be involved in the control of growth factor availability . Negative_regulation MMP7 TIMP1 11466032 839753 [Matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) have been found in high concentrations in pleural effusions . Negative_regulation MMP7 TIMP1 11468168 840860 Two [MMP] *inhibitors* , and Ro 32-1541 , did not block L-selectin shedding and had no effect on lymphocyte migration across HEVs . Negative_regulation MMP7 TIMP1 11522015 852658 The concentrations of t-PA , PAI-1 , collagenase ( MMP-1 ) , tissue *inhibitor* of [MMP] ( ) , plasmin-antiplasmin (PAP) complexes and alpha2-macroglobulin (alpha2-M) were measured in plasma samples . Negative_regulation MMP7 TIMP1 11730752 884999 To assess the presence of matrix metalloproteinase ( MMP-1 ) and tissue *inhibitor* of [MMP] ( ) in peritoneal fluid and serum of subjects with and without adhesions . Negative_regulation MMP7 TIMP1 11730753 885024 To compare expression of matrix metalloproteinase ( MMP-1 ) and tissue *inhibitor* of [MMP] ( ) in serosal tissue of intraperitoneal organs and adhesions . Negative_regulation MMP7 TIMP1 11792149 901848 Genetic therapy aimed at disturbing the balance between [matrix metalloproteinases (MMP)] and their natural tissue *inhibitors* ( ) in treatment of pancreatic cancer requires an understanding of whether MMP and TIMP are tumor- or host derived . Negative_regulation MMP7 TIMP1 11813512 892802 This is further substantiated by the finding that smooth muscle cell (SMC) migration and neointima formation after vascular injury is significantly enhanced in mice with deficiency of , the main physiological [MMP] *inhibitor* . Negative_regulation MMP7 TIMP1 11841792 912214 , the physiological [MMP] *inhibitor* , increased during granulocytic differentiation whereas TIMP-2 did not significantly vary . Negative_regulation MMP7 TIMP1 11886844 919993 When Jurkat cells were stimulated with PMA in the presence of a BB94 , a [matrix metalloproteinase (MMP)] *inhibitor* , but not tissue inhibitor of metalloproteinase-1 ( ) , the release of galectin-9 was suppressed in a dose dependent manner . Negative_regulation MMP7 TIMP1 11985514 935705 We studied the [matrix metalloproteinase (MMP)] and their tissue *inhibitor* ( ) expression pattern in experimental autoimmune encephalomyelitis ( EAE ) of the resistant Th2 prone BALB/c mouse , where the disease can be induced with ultrasound emulsified antigen/adjuvant ( son-ag ) , but not with conventional technique ( syr-ag ) . Negative_regulation MMP7 TIMP1 11988491 936343 These data suggest that enhanced [MMP] activity , as a *result* of deficiency , contributes to a reduction of atherosclerotic plaque size but promotes aneurysm formation . Negative_regulation MMP7 TIMP1 12034400 948729 Alterations in [MMP] expression and their endogenous *inhibitor* ( ) may factor in HCC metastasis . Negative_regulation MMP7 TIMP1 12053120 951024 Here , we determine changes in the [matrix metalloproteinases (MMP)] and their tissue *inhibitors* ( ) in relation to ECM production and the progression of renal fibrosis in subtotally nephrectomized ( SNx ) rats . Negative_regulation MMP7 TIMP1 12118337 964812 Furthermore , RT-PCR showed that ACLA increased MMP-9 and tissue *inhibitor* of [MMP] ( ) expression in a ROS dependent manner . Negative_regulation MMP7 TIMP1 12468644 1022657 Comparison of mRNA levels of a panel of collagens , [matrix metalloproteinases (MMP)] , tissue *inhibitors* of metalloproteinases ( ) and cathepsins in the samples revealed higher levels of type I collagen , MMP-2 and cathepsin H and decreased levels of TIMP-3 mRNA in mid-secretory endometrium of patients with unexplained infertility and/or recurrent miscarriages when compared with normal mid-secretory endometrium . Negative_regulation MMP7 TIMP1 12506070 1038311 TNFalpha is a strong modulator expression of trabecular meshwork ( TM ) [matrix metalloproteinase (MMP)] and tissue *inhibitor* ( ) . Negative_regulation MMP7 TIMP1 12557216 1051832 To characterize differences in ear wounding responses between regenerating and nonregenerating mice , we examined and compared the extracellular matrix remodeling and the [matrix metalloproteinase (MMP)] and tissue *inhibitor* of metalloproteinase ( ) response in the MRL and C57BL/6 mouse strains after injury . Negative_regulation MMP7 TIMP1 12708162 1082913 Participation of [matrix metalloproteinases (MMP)] and their tissue *inhibitors* ( ) in the rupture of fetal membranes ( FM ) during labor has been proposed . Negative_regulation MMP7 TIMP1 1339165 209191 As serum markers for hepatitis fibrosis , prolyl hydroxylase ( PH ) , type III procollagen peptide ( PIIIP ) , type IV collagen , [mesenchymal metalloproteinase (MMP)] , tissue *inhibitor* of metalloproteinase ( ) and laminin are reliable for clinical application . Negative_regulation MMP7 TIMP1 1392165 198810 These MMPs and the [MMP] tissual *inhibitor* ( ) were detected by immunohistochemistry in 30 benign and 79 malignant lesions of the breast . Negative_regulation MMP7 TIMP1 14644158 1172006 In addition , , a natural [MMP] *inhibitor* , significantly reduced the invasion of RhoAV14 expressing cells , suggesting that MMP-9 was a critical metalloproteinase responsible , at least partly , for the RhoAV14 induced endothelial cell invasion . Negative_regulation MMP7 TIMP1 14729679 1220086 It was blocked by synthetic [MMP] *inhibitors* , TIMP2 , but not and abolished by a partial deletion of the catalytic domain or the cytoplasmic tail of MT1-MMP . Negative_regulation MMP7 TIMP1 14966582 1182626 To study the expression of [matrix metalloproteinase(MMP)] and tissue *inhibitor* of metalloproteinase ( ) in ameloblastoma ( AB ) and to determine the relationship between biological behavior of AB and clinical pathology . Negative_regulation MMP7 TIMP1 14990551 1257007 The purpose of this study was to investigate the effects of high-force eccentric muscle contractions on collagen remodeling and on circulating levels of [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) in humans . Negative_regulation MMP7 TIMP1 15162254 1252980 [Matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) have been found by ELISA and gelatine zymography in different concentrations in pleural fluid in tuberculous ( TB ) pleuritis . Negative_regulation MMP7 TIMP1 15364860 1294399 gene transfer *inhibits* [MMP] activity and preserves cardiac function and geometry in ischemic cardiomyopathy . Negative_regulation MMP7 TIMP1 15364874 1294423 We hypothesized that removal of the primary endogenous aortic [MMP] *inhibitor* ( ) through TIMP-1 gene deletion will increase TAA progression . Negative_regulation MMP7 TIMP1 15389186 1300384 We investigated the expression of [matrix metalloproteinase (MMP)] and its tissue *inhibitor* ( ) in fibrous plaques , angiofibromas , and lesion-free skin specimens from patients with tuberous sclerosis complex . Negative_regulation MMP7 TIMP1 15390257 1334926 ( TIMP-1 ) , a natural [MMP] *inhibitor* , was shown to reduce metastasis in different models . Negative_regulation MMP7 TIMP1 15502710 1327358 The [MMP] *inhibitors* , and TIMP-2 , were significantly reduced in the urine of mice with normally regenerating livers but were increased in the urine of mice treated with TNP-470 on day 8 . Negative_regulation MMP7 TIMP1 15781321 1385533 [Matrix metalloproteinases (MMP's)] and tissue *inhibitors* of metalloproteinases ( 's ) possess a preponderant role in the metabolism of the major extracellular matrix protein , collagen , and are thought to be important in the mechanism of tumor invasion . Negative_regulation MMP7 TIMP1 15795420 1387228 Total collagen IV , the different alpha ( IV ) chains , matrix degrading metalloproteinases ( [MMP] ) , and tissue *inhibitors* of metalloproteinases ( ) were quantified by immunocytochemistry and/or Western blotting . Negative_regulation MMP7 TIMP1 15980226 1424689 At various time points after injury ( PI ) , corneas from the Tbeta4- versus the PBS treated group were examined for polymorphonuclear leukocyte ( PMN ) infiltration , chemokine , and [matrix metalloproteinase (MMP)/tissue] *inhibitor* of metalloproteinase ( ) expression . Negative_regulation MMP7 TIMP1 16019435 1432059 Either human or bovine *inhibited* [matrix metalloproteinase (MMP)] activities , such as collagenolytic , gelatinolytic and caseinolytic , expressed by mouse cells as well as those expressed by human cells . Negative_regulation MMP7 TIMP1 16051697 1466158 Abnormal expression of matrix components [ collagen IV , fibronectin , matrix metalloproteinase 9 (MMP-9) and [MMP] tissue *inhibitor* 1 ( ) ] was also significantly reversed by iptakalim . Negative_regulation MMP7 TIMP1 16110415 1445323 [Matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) play a crucial role in physiological and pathological matrix turnover . Negative_regulation MMP7 TIMP1 16500763 1528988 Expression of collagen , [matrix metalloproteinase (MMP)] , and tissue *inhibitor* of metalloproteinase-1 ( ) were determined by real-time PCR . Negative_regulation MMP7 TIMP1 16574944 1598136 The [MMP] *inhibitors* , and TIMP-2 , were also increased at 7-28 d after asbestos exposure . Negative_regulation MMP7 TIMP1 17045020 1635669 OPN can protect against hyperoxia induced ALI by promoting the expression of and *inhibiting* the activation of [MMP] . Negative_regulation MMP7 TIMP1 17186573 1688401 We have recently established the expression and secretion profiles of interleukin (IL)-8 , [matrix metalloproteinase (MMP)-7] , MMP-9 , and tissue *inhibitor* of metalloproteinase ( ) -1 during non-CF airway epithelial regeneration in a humanized nude mouse xenograft model . Negative_regulation MMP7 TIMP1 17334003 1707582 The lowest concentrations of [MMP] *inhibitor* ( ) were observed in patients with periodontitis , in whom the concentrations increased after periodontal treatment . Negative_regulation MMP7 TIMP1 17336841 1707667 We profiled the expression of the entire [matrix metalloproteinase (MMP)] , tissue *inhibitor* of metalloproteinases ( ) , and a disintegrin and metalloproteinase domain with thrombospondin motif ( ADAMTS ) gene families in these tissues using real-time reverse-transcription polymerase chain reaction . Negative_regulation MMP7 TIMP1 17543340 1888684 We examined expression patterns of [matrix metalloproteinase (MMP)] , tissue *inhibitor* of metalloproteinase ( ) , and reversion inducing cysteine-rich protein with Kazal motifs ( RECK ) in colorectal cancer tissues to assess their prognostic significance . Negative_regulation MMP7 TIMP1 17868665 1796053 [Matrix metalloproteinases (MMP)] and tissue *inhibitor* of metalloproteinases ( ) trigger the signal cascade instigating cardiac remodeling and fibrosis , which lead to changes of repolarization variables . Negative_regulation MMP7 TIMP1 17942699 1814061 Low exogenous NO perturbed [MMP/tissue] *inhibitor* of metalloproteinase ( ) -1 levels by enhancing MMP activity and suppressing the endogenous inhibitor TIMP-1 . Negative_regulation MMP7 TIMP1 18493720 1939309 Degradation and remodelling of the extracellular matrix has been investigated , with the main focus on the balance between [matrix metalloproteinases (MMP)] and tissue *inhibitor* of metalloproteinases ( ) . Negative_regulation MMP7 TIMP1 18826601 1981622 Balance between [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) in the cervical mucus plug estimated by determination of free non complexed TIMP . Negative_regulation MMP7 TIMP1 19134356 2005779 To investigate the roles of [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) in dentinogenic ghost cell tumor ( DGCT ) and ghost cell odontogenic carcinoma ( GCOC ) . Negative_regulation MMP7 TIMP1 19262092 1841147 Gelatin and reverse zymogram assays were used to determine the enzyme activities of [matrix metalloproteinases (MMP)] and tissue *inhibitor* of metalloproteinases ( ) . Negative_regulation MMP7 TIMP1 19270735 2045688 We silenced expression of three insect-type Tribolium [MMP] paralogs and their physiological *inhibitors* , and RECK , by dsRNA mediated genetic interference ( RNAi ) . Negative_regulation MMP7 TIMP1 19615945 2130890 The influence of 1 , 25 ( OH ) ( 2 ) D ( 3 ) on [MMP-7] , MMP-9 and tissue *inhibitor* of metalloproteinase-1 ( ) , production was studied in 43 pulmonary tuberculosis (PTB) patients and 44 healthy controls ( HC ) . Negative_regulation MMP7 TIMP1 19627579 2137634 [Matrix metalloproteinase (MMP)] and tissue *inhibitor* ( ) were assessed by ELISA and zymography . Negative_regulation MMP7 TIMP1 19698156 2126762 To evaluate levels of [matrix metalloproteinases (MMP)] and their *inhibitors* ( ) in second trimester amniotic fluid of women with hypertensive disorders compared to normotensive women . Negative_regulation MMP7 TIMP1 20531021 2295551 We compared specific matrix metalloproteinases ( MMP-2 and MMP-9 ) and 1 [MMP] *inhibitor* ( ) activities or expression in human milk ( HM ) fed to 18 preterm infants and 13 full-term infants , obtained at 72 hours and 1 and 2 weeks postpartum . Negative_regulation MMP7 TIMP1 20581102 2309134 Nitric oxide ( NO ) is a potential regulator of matrix metalloproteinase (MMP) activity in [MMP-NO-tissue] *inhibitor* of metalloproteinase ( ) inhibitory tertiary complex . Negative_regulation MMP7 TIMP1 20621951 2286795 [Matrix metalloproteinases (MMP)] and tissue *inhibitor* of matrix metalloproteinase-1 ( ) are involved in blood brain barrier disruption and formation of MS lesions . Negative_regulation MMP7 TIMP1 20654099 2297943 To compare right atrial structural remodeling and the expression of [matrix metalloproteinase (MMP)] and tissue *inhibitors* ( ) between patients with unstable angina ( UA ) and myocardial infarction ( MI ) . Negative_regulation MMP7 TIMP1 20683000 2299004 [Matrix metalloproteinase-7 (MMP-7)] , MMP-9 , MMP-13 , and tissue *inhibitor* of matrix metalloproteinase-1 ( ) are considered to have important roles in the invasiveness and outcomes of colorectal cancer ( CRC ) . Negative_regulation MMP7 TIMP1 20713758 2306631 Polymerase chain reaction analysis of transforming growth factor-beta1b , insulinlike growth factor (IGF)-1 , [matrix metalloproteinase (MMP)-7] , MMP-9 , tissue *inhibitor* of metalloproteinase 1 ( ) , and prostaglandin E receptor EP4 expression was performed as well . Negative_regulation MMP7 TIMP1 21033407 2181990 Metalloproteinases ( [MMP] ) and their tissue *inhibitors* ( ) play a crucial role to keep the balance between the synthesis and degradation of extracellular matrix protein . Negative_regulation MMP7 TIMP1 21105842 2395792 In diseased pulmonary arteries , the balance between [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) is broken down . Negative_regulation MMP7 TIMP1 21148111 2390203 Tissue *inhibitor* of [MMP] ( ) was elevated with age but protected by ET . Negative_regulation MMP7 TIMP1 21428178 2361470 To describe the enzymatic profile of plasma matrix metalloproteinases ( [MMP-7] and -9 ) and tissue *inhibitors* of metalloproteinases ( and -2 ) in different categories of patients ( pts. ) with coronary artery disease ( CAD ) , and their relationship with clinical status , left ventricular ( LV ) function and remodelling . Negative_regulation MMP7 TIMP1 21854733 2546670 [MMP-7] ( median 0.47 ng/ml ) , MMP-8 ( median 31.16 ng/ml ) and MMP-9 ( median 253.00 ng/ml ) levels were elevated and levels *suppressed* ( median 78.50 ng/ml ) in cardiac arrest patients as compared with healthy controls at 24h from ROSC . Negative_regulation MMP7 TIMP1 21959615 2488249 The aim of this study was to verify whether polymorphisms of MMP2 C-735T , [MMP7] A-181G , MMP9 T-1702A and tissue *inhibitor* of metalloproteinase ( ) 2 G-418C predispose to sarcoidosis . Negative_regulation MMP7 TIMP1 22033229 2527423 This broader view reflects our emerging understanding that signaling and [MMP] *inhibition* represent two important functions of TIMPs that have the potential to affect tissue pathology . Negative_regulation MMP7 TIMP1 22042083 2540106 This effect may be partially mediated by increased MMP-2 and activities in the aortic wall and *reduced* TNFa stimulated inflammation and [MMP] activation in macrophages . Negative_regulation MMP7 TIMP1 22467128 2578602 The production of , an endogenous [matrix metalloproteinase (MMP)] *inhibitor* , was observed in CBA/J mice . Negative_regulation MMP7 TIMP1 22591289 2632139 [Matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) have been implicated in chronic obstructive pulmonary disease ( COPD ) pathogenesis . Negative_regulation MMP7 TIMP1 22798012 2645648 This effect resulted from the presence of the potent [MMP] *inhibitors* , ( TIMP-1 ) , type-1 plasminogen activator inhibitor ( PAI-1 ) and thrombospondin-1 (TSP-1) in the amnion dressings , as shown by real-time fluorescence zymography and protein microarrays . Negative_regulation MMP7 TIMP1 22929563 2744930 During thoractomy , samples of the right auricle were taken and immunohistochemical staining and fluorescence quantitative PCR were performed to test matrix metalloproteinase (MMP) 1 , MMP-3 , [MMP-7] , MMP-9 , tissue *inhibitor* of metalloproteinase ( ) 1 , TIMP-2 , TIMP-3 and TIMP-4 expression of the samples . Negative_regulation MMP7 TIMP1 23071737 2690008 Next , in vivo Near-InfraRed-Fluorescence imaging demonstrated that electroporation mediated *reduced* local [MMP] activity in vein grafts by 73 % ( p < 0.01 ) . Negative_regulation MMP7 TIMP1 23073243 2735313 Cardiovascular remodeling found in later phases of two-kidney , one-clip ( 2K1C ) hypertension may involve key mechanisms particularly including MMP-2 , oxidative stress , transforming growth factor-ß ( TGF-ß ) , and inactivation of the endogenous [MMP] *inhibitor* , the . Negative_regulation MMP7 TIMP1 23100416 2690975 Moreover , noise induced expression changes in two endogenous [MMP] *inhibitors* , and Timp2 , in sensory cells were dependent on the stage of nuclear condensation , suggesting a specific role for MMP activity in sensory cell apoptosis . Negative_regulation MMP7 TIMP1 23122666 2780386 Wound sections were analyzed by immunostaining for metalloproteinase ( MMP) 2 , [MMP7] , MMP9 , tissue *inhibitor* of metalloproteinases ( ) 1 , and tumor necrosis factor (TNF) a on days 2 , 4 , and 12 . Negative_regulation MMP7 TIMP1 23218521 2786083 In this study , we examined the expression patterns of MMP-13 and [MMP] *inhibitors* , and TIMP-2 , in immature ( 4weeks ) , pre-pubertal ( 16weeks ) , and mature ( 1year ) chicken testes . Negative_regulation MMP7 TIMP1 23493620 2803933 Functional inhibition of TIMP-1 prevented the KA-induced impairment of Reelin cleavage indicating that *inhibits* [MMP] activity . Negative_regulation MMP7 TIMP1 23583449 2783748 , a well-known [MMP] *inhibitor* , displays other biological activities such as cell survival , proliferation and differentiation in hematopoietic cells . Negative_regulation MMP7 TIMP1 24065532 2857744 In contrast , mRNA expression of tissue inhibitor of matrix metalloproteinase ( ) -1 , a [MMP] *inhibitor* , was increased by 10-120 µg/ml of PS but not that of TIMP-2 . Negative_regulation MMP7 TIMP1 24086305 2847787 As interplay of TNF-a , TGF-ß , [matrix metalloproteinases (MMP)] , and tissue *inhibitors* of metalloproteinases ( ) is important in wound healing in general , TNF-a , TGF-ß , MMP7 , and TIMP1 were assessed immunohistochemical in samples of wounded ears harvested on days 2 , 6 , 10 and 16 after wounding . Negative_regulation MMP7 TIMP1 24367771 2881849 Tissue *inhibitor* of [MMP] ( ) gene expression decreased after CPX treatment , whilst TIMP-2 and transforming growth factor-ß1 gene expression , the cytoskeleton arrangement , and cytochrome c expression remained unmodified . Negative_regulation MMP7 TIMP1 24471121 2884725 Our results showed that the core protein of NIPP-1 peptide prevented fibril formation of type I collagen , elevated the [MMP] level and *inhibited* production in a dose dependent manner . Negative_regulation MMP7 TIMP1 24766991 2939518 Variance of [matrix metalloproteinase (MMP)] and tissue *inhibitor* of metalloproteinase ( ) concentrations in activated , concentrated platelets from healthy male donors . Negative_regulation MMP7 TIMP1 7933807 275448 The present study was designed to assess whether expression of mRNA for extracellular matrix (ECM) components , metalloproteinases ( [MMP] ) and tissue *inhibitor* of metalloproteinases ( ) in glomeruli is affected by a low protein diet during the course of focal glomerulosclerosis (FGS) . Negative_regulation MMP7 TIMP1 7989608 282889 The [MMP] *inhibitors* , EDTA and 1,10-phenanthroline , as well as recombinant , reduced these activities which colocalized with regions of increased immunoreactive MMP expression , i.e. , the shoulders , core , and microvasculature of the plaques . Negative_regulation MMP7 TIMP1 8207529 261463 The role of [matrix metalloproteinases (MMP's)] and their *inhibitor* , ( TIMP-1 ) , in human brain tumor invasion was investigated . Negative_regulation MMP7 TIMP1 8686751 370319 The [MMP] *inhibitor* , , was expressed in both stromal and tumor components in most tumors , and neither stromelysin-2 nor neutrophil collagenase were detected in any of the tumors . Negative_regulation MMP7 TIMP1 8922288 397101 When the complex *inhibits* an [MMP] , a quaternary complex monomer/lipocalin/TIMP-1/MMP is generated which after activation shows a sixfold higher proteolytic activity than the active ternary complex . Negative_regulation MMP7 TIMP1 9101722 423086 The k ( on ) for *inhibition* of [matrilysin] was lower ( 0.130 x 10 ( 5 ) M ( -1 ) s ( -1 ) ) supporting the observation that no SDS stable complexes were detected . Negative_regulation MMP7 TIMP1 9276670 450748 Both a tissue inhibitor of metalloproteinases-1 ( ) and a synthetic hydroxamate [MMP] *inhibitor* prevented this collagen release . Negative_regulation MMP7 TIMP1 9438380 474988 Since angiogenesis does not occur in large blood vessels , we investigated whether the secretion of MMPs and tissue *inhibitor* of [MMP] ( ) differs between micro- and macro-vascular endothelial cells . Negative_regulation MMP7 TIMP1 9524323 494587 Calvariae produced a high level of [MMP] *inhibitor* ( ) , especially under the influence of the cytokines ; Negative_regulation MMP7 TIMP1 9570393 478041 To investigate the relation between [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) in malignant ovarian tumor , MMP and TIMP activities in conditioned media of 16 malignant ovarian tumor tissues and six normal ovaries were detected by zymography and reverse zymography , respectively and were quantitated with a densitometer . Negative_regulation MMP7 TIMP1 9804345 544265 To better understand the pathogenesis of ulcer formation we investigated the expression of [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( ) in lipodermatosclerosis . Negative_regulation MMP7 TIMP2 10642509 660885 In contrast , activation of pro-MMP-2 by [sMT1-MMP] was dose-dependently *inhibited* by . Negative_regulation MMP7 TIMP2 10818225 693872 The natural [MMP] *inhibitors* , and TIMP-4 were unable to inhibit ADAM-10 , but TIMP-1 and TIMP-3 were inhibitory . Negative_regulation MMP7 TIMP2 11346466 814305 MMP2 is activated by membranous type-1 MMP (MT1-MMP) and type-2 tissue *inhibitor* of [MMP] ( ) . Negative_regulation MMP7 TIMP2 11382769 835025 In contrast to the stimulatory effect of TIMP-2 on pro-MMP-2 activation by MT1-MMP , activation of pro-MMP-2 by [DeltaMT1-MMP] in the presence of claudin-5 and proDeltaMMP-2 processing by MT1-MMP were both inversely *repressed* by expression of exogenous . Negative_regulation MMP7 TIMP2 12269680 990663 To comparatively analyse the expression of matrix metalloproteinase ( MMP-3 ) and tissue *inhibitor* of [MMP] ( ) in serosal tissue of intraperitoneal organs and adhesions , as well as peritoneal fluid and serum of subjects with and without adhesions . Negative_regulation MMP7 TIMP2 12900406 1150268 To address these differences , a series of structure-function studies were conducted to identify and to characterize the anti-angiogenic domains of , the endogenous [MMP] *inhibitor* that uniquely inhibits capillary endothelial cell ( EC ) proliferation as well as angiogenesis in vivo . Negative_regulation MMP7 TIMP2 14593002 1176288 When small renal arteries were incubated with either of the general [MMP] *inhibitors* , GM6001 or ( tissue inhibitor of MMP ) , or with the specific gelatinase inhibitor , cyclic CTT , the reduced myogenic reactivity of these blood vessels from relaxin treated nonpregnant and midterm pregnant rats was totally abolished . Negative_regulation MMP7 TIMP2 14729679 1220087 It was blocked by synthetic [MMP] *inhibitors* , , but not TIMP-1 and abolished by a partial deletion of the catalytic domain or the cytoplasmic tail of MT1-MMP . Negative_regulation MMP7 TIMP2 15502710 1327359 The [MMP] *inhibitors* , TIMP-1 and , were significantly reduced in the urine of mice with normally regenerating livers but were increased in the urine of mice treated with TNP-470 on day 8 . Negative_regulation MMP7 TIMP2 16323056 1488028 The mRNA levels of preproET-1 , endothelin converting enzyme ( ECE-1 ) , ETa receptor and ETb receptor , matrix metalloproteinase ( MMP-2 ) , tissue *inhibitor* of [MMP] ( ) , and heat shock protein ( HSP-70 ) were determined by quantitative real-time RT-PCR . Negative_regulation MMP7 TIMP2 16574944 1598137 The [MMP] *inhibitors* , TIMP-1 and , were also increased at 7-28 d after asbestos exposure . Negative_regulation MMP7 TIMP2 20000122 2174819 The aim of this study was to elucidate peculiarity of expression of gelatinases A and B ( MMP-2 and MMP-9 ) , membrane type MMP ( MT1-MMP ) and tissue *inhibitor* of [MMP] ( ) in immortal ( IF ) and transformed fibroblasts ( TF ) . Negative_regulation MMP7 TIMP2 20626034 2321857 PACs increased the expression of , a known *inhibitor* of [MMP] activity , and decreased the expression of EMMPRIN , an inducer of MMP expression . Negative_regulation MMP7 TIMP2 21428178 2361471 To describe the enzymatic profile of plasma matrix metalloproteinases ( [MMP-7] and -9 ) and tissue *inhibitors* of metalloproteinases ( ) in different categories of patients ( pts. ) with coronary artery disease ( CAD ) , and their relationship with clinical status , left ventricular ( LV ) function and remodelling . Negative_regulation MMP7 TIMP2 23000197 2689218 The role of matrix metalloproteinases ( MMP-3 and MMP-9 ) , tissue *inhibitor* of [MMP] ( ) , and GAP-43 ( growth-associated-protein ) in neocerebellar vermis lobules during postnatal histogenesis was studied after challenge with cisplatin ( cisPt ) . Negative_regulation MMP7 TIMP2 23100416 2690976 Moreover , noise induced expression changes in two endogenous [MMP] *inhibitors* , Timp1 and , in sensory cells were dependent on the stage of nuclear condensation , suggesting a specific role for MMP activity in sensory cell apoptosis . Negative_regulation MMP7 TIMP2 23218521 2786084 In this study , we examined the expression patterns of MMP-13 and [MMP] *inhibitors* , TIMP-1 and , in immature ( 4weeks ) , pre-pubertal ( 16weeks ) , and mature ( 1year ) chicken testes . Negative_regulation MMP7 TIMP2 24640096 2886460 Results of comparative immunoenzymatic study of matrix metalloproteinase (MMP) 2 , 8 and 9 , interleukins ( IL ) If and 6 , tissue [MMP] *inhibitors* ( TIMP-1and ) and TNF-a in oral fluid of patients with different teeth and denture constructive materials show that MMP-9 content in oral fluid can serve as a marker of chronic generalized periodontitis because it is elevated in all patients irrespective of presence or absence of metallic tooth restorations . Negative_regulation MMP7 TIMP2 9009103 410907 The degradation of fluorogenic substrates by MMPs could be inhibited by the chelating agent EDTA and by the ( TIMP-2 ) , an [MMP-specific] *inhibitor* . Negative_regulation MMP7 TIMP3 11960708 932422 We examined the expression patterns of two [MMP] *inhibitors* , tissue inhibitor of metalloproteinase ( TIMP ) -2 and , during critical stages of cardiac development . Negative_regulation MMP7 TIMP3 18360715 1887823 Concomitantly , cell proliferation decreased and expression of prostate-specific antigen (PSA) mRNA and its secretion were diminished , whereas expression of IGF binding protein 3 (IGFBP-3) and [MMP] tissue *inhibitor* 3 ( ) was up-regulated . Negative_regulation MMP7 TIMP3 19795442 2209098 Gene array analysis revealed that blocking Snail expression suppressed the activity of matrix metalloproteinases ( MMPs ) and upregulated , an [MMP] *inhibitor* . Negative_regulation MMP7 TIMP3 9712149 527219 Transforming growth factor beta ( TGF-beta ) , an inducer of matrix synthesis , potently enhances mRNA and protein of a recently characterized [MMP] *inhibitor* , , in bovine articular chondrocytes . Negative_regulation MMP7 TIMP4 10818225 693873 The natural [MMP] *inhibitors* , TIMP-2 and were unable to inhibit ADAM-10 , but TIMP-1 and TIMP-3 were inhibitory . Negative_regulation MMP7 TIMP4 12707244 1086195 Loss of from the cardiac myocyte *leads* to an increase in net myocardial [MMP] activity that contributes to acute myocardial stunning injury . Negative_regulation MMP7 TIMP4 12923405 1131140 The increased levels of in the medulla may *inhibit* the collagenolytic activity of [MMP] but is unable to inhibit the elastinolytic activity . Negative_regulation MMP7 TIMP4 16682001 1559628 Despite the importance of MMP activity in the regulation of angiogenesis , relatively little is known about the role of , the most recently discovered endogenous [MMP] *inhibitor* , in modulating neovascularization . Negative_regulation MMP7 TNF 12506070 1038348 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in [MMP] and TIMP expression . Negative_regulation MMP7 TNF 15145598 1247711 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of [MMP] and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation MMP7 TNF 15663564 1350384 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Negative_regulation MMP7 TNF 16106101 1445004 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Negative_regulation MMP7 TNF 17469134 1737496 OSM and stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP7 TNF 19281093 2007630 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Negative_regulation MMP7 TNF 22202225 2519010 In addition , we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as ( TNF-B ) , interferon-alpha ( IFN-a ) , transforming growth factor-beta (TGF-B) , interleukins ( IL ) such as IL1-B and IL-6 , as well as [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( TIMP ) . Negative_regulation MMP7 TNFSF10 23582782 2778439 however , the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus *induced* loss of [MMP] and apoptosis . Negative_regulation MMP7 TNP1 10665843 578468 There was no *induced* inhibition of [MMP] collagenase activity or MMP ( MMP2 and MMP9 ) production in the human fibrosarcoma cells HT 1080 in vitro . Negative_regulation MMP7 TNP2 10665843 578469 There was no *induced* inhibition of [MMP] collagenase activity or MMP ( MMP2 and MMP9 ) production in the human fibrosarcoma cells HT 1080 in vitro . Negative_regulation MMP7 TSR1 10900205 736878 Tissue culture and in vitro assays demonstrated that the presence of purified and intact TSP1 *resulted* in inhibition of [MMP] activity . Negative_regulation MMP7 TSR2 10900205 736877 Tissue culture and in vitro assays demonstrated that the presence of purified and intact TSP1 resulted in *inhibition* of [MMP] activity . Negative_regulation MMP7 TSR3 10900205 736876 Tissue culture and in vitro assays demonstrated that the presence of purified and intact TSP1 *resulted* in inhibition of [MMP] activity . Negative_regulation MMP7 UTRN 22388349 2636736 Drp1 siRNA and small molecule inhibitors of *prevented* mitochondrial fission , loss of mitochondrial [membrane potential (MMP)] , and cell death induced by glutamate or tBid overexpression in immortalized hippocampal HT-22 neuronal cells . Negative_regulation MMP7 VEGFA 12600446 1062245 Blockade of ( VEGF ) and *inhibition* of [matrix metalloproteinases (MMP)] are promising therapies for cancer . Negative_regulation MMP7 VEGFA 12600446 1062289 Both blockade and [MMP] *inhibition* reduce primary tumor size , metastasis , and angiogenesis , thereby increasing survival in experimental pancreatic cancer . Negative_regulation MMP7 VEGFA 21118050 2389942 To test the stability of [matrix metalloproteinases-7 (MMP-7)] and their tissue *inhibitors* ( TIMP-1 ) , vascular growth factors ( ) and VEGF-receptor , serum samples were frozen and then thawed up to six times . Negative_regulation MMP7 VIP 15096214 1238763 , at 10 ( -7 ) m , *reduced* CSE stimulated [MMP] activity and caspase-3 activation . Negative_regulation MMP7 WDR61 23911909 2840282 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Negative_regulation MMP7 WISP1 19180479 2033108 Adenoviral overexpression of in murine knee joints *induced* [MMP] and aggrecanase expression and resulted in cartilage damage . Negative_regulation MMP7 WNT1 22328140 2629840 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Negative_regulation MMP7 WNT11 22328140 2629841 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Negative_regulation MMP7 WNT16 22328140 2629846 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Negative_regulation MMP7 WNT2 22328140 2629842 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Negative_regulation MMP7 WNT3 22328140 2629843 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Negative_regulation MMP7 WNT4 22328140 2629844 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Negative_regulation MMP7 WNT6 22328140 2629845 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Negative_regulation MMP7 WNT7A 22232518 2569237 Overexpression of *stimulated* [matrix metalloproteinase 7 (MMP7)] promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of MMP7 promoter by WNT7A was mediated by ß-catenin/TCF signaling . Negative_regulation MMP8 EFNB1 17567680 1763204 In support of this hypothesis , activation of increased GTP bound Arf1 , and the secretion of [MMP-8] was *reduced* by expression of a dominant negative mutant of Arf1 . Negative_regulation MMP8 FAS 11980895 954092 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of [MMP] and cytochrome c release . Negative_regulation MMP8 HBEGF 17322418 1747793 Inhibition of ( HB-EGF ) release by CRM-197 and *inhibition* of [matrix metalloproteinases (MMP)] by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation . Negative_regulation MMP8 IL1B 16122880 1461096 A dose dependent inhibition of and TPA *stimulated* [MMP] activity by gallium nitrate at increasing concentrations occurs , demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis . Negative_regulation MMP8 PLAT 22244977 2564149 We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle , delayed tPA alone , or combined ( 10 mg/kg , i.v. ) plus GM6001 ( 100 mg/kg , i.p. ) , a broad-spectrum [MMP] *inhibitor* . Negative_regulation MMP8 PLAU 12117412 997468 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Negative_regulation MMP8 PLAU 24418973 2942390 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 in the conditioned media . Negative_regulation MMP8 TFPI2 20015200 2489014 Moreover , down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in a ( 1 ) integrin on cell surface , and *increased* [MMP] expression ( mainly MMP-1 and -3 ) contributing to cancer cell invasion through basement membrane components . Negative_regulation MMP8 TNF 12506070 1038349 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in [MMP] and TIMP expression . Negative_regulation MMP8 TNF 15145598 1247712 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of [MMP] and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation MMP8 TNF 15663564 1350385 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Negative_regulation MMP8 TNF 16106101 1445005 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Negative_regulation MMP8 TNF 17469134 1737498 OSM and stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP8 TNF 19281093 2007631 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Negative_regulation MMP8 TNF 22202225 2519011 In addition , we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as ( TNF-B ) , interferon-alpha ( IFN-a ) , transforming growth factor-beta (TGF-B) , interleukins ( IL ) such as IL1-B and IL-6 , as well as [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( TIMP ) . Negative_regulation MMP8 TNFSF10 23582782 2778440 however , the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus *induced* loss of [MMP] and apoptosis . Negative_regulation MMP9 ANGPT1 14615417 1163799 The stimulation of cultured retinal endothelial cells with and -2 *resulted* in the increased expression of [matrix metalloproteinase (MMP)-9] . Negative_regulation MMP9 ARSA 20137092 2227038 Our results showed that *inhibited* [MMP-9] mRNA expression , and caused the decrease in the MMP-9 activities from the cell culture supernatants . Negative_regulation MMP9 CD14 19841036 2209521 Furthermore , preserved the leukocyte count and significantly *reduced* granulocyte enzyme [matrix metalloproteinase-9] release and expression of the granulocyte membrane activation molecule wCD11R3 ( pig CD11b ) . Negative_regulation MMP9 CD14 21281805 2387765 Using a mouse model of Lyme arthritis , we demonstrate that deficiency *leads* to decreased activation of [matrix metalloproteinase 9] , reduced degradation of collagen , and diminished recruitment of neutrophils . Negative_regulation MMP9 CLU 22440257 2588395 The significance of the interaction between CLU and MMP-9 was demonstrated by the observation that prevents stress induced MMP-9 aggregation and *inhibits* [MMP-9] enzymatic activity . Negative_regulation MMP9 EPHB2 11315098 765095 In the current study , we examined the *role* of JNK- and dependent signaling modules in the regulation of [MMP-9] production and the invasive behavior of the human glioblastoma cell line SNB19 , in which JNK/ERK1 is constitutively activated . Negative_regulation MMP9 EPHB2 11709424 879802 To determine the *role* of in IL-1 beta stimulated [MMP-9] induction , we treated cells with the specific ERK pathway inhibitor PD-98059 at different time intervals after IL-1 beta stimulation . Negative_regulation MMP9 EPHB2 15728252 1382891 Inhibition of MEK/ERK signaling in wild-type MK cells with a pharmacological inhibitor , U0126 , showed that activation was *necessary* for high levels of endogenous [MMP-9] gene expression and activity of a transfected MMP-9 promoter . Negative_regulation MMP9 EPHB2 19299917 2064161 A chemical inhibitor of MEK1/2 or PI3K reduced phosphorylation of or Akt , respectively , and also *inhibited* CSE mediated [MMP-9] induction . Negative_regulation MMP9 EPHB2 20093109 2226137 Our results show that TNF-alpha induced expression of [MMP-9] at both mRNA and protein levels was completely *blocked* by in a concentration dependent ( 1-20microM ) manner . Negative_regulation MMP9 EPHB2 20093109 2226141 Overall , our findings suggest that *inhibits* [MMP-9] production through the nuclear targeted down-regulation of NF-kappaB signaling in human monocytic cells and this may provide a novel molecular basis of EK5 activity . Negative_regulation MMP9 EPHB2 20224727 2223613 Phosphorylation of focal adhesion kinase ( FAK ) , , PI-3K and nuclear translocation of EGFR and NF-kB upon FN binding demonstrate possible involvement of FAK/PI-3K/ERK signalling pathways in the fibronectin-integrin *mediated* up regulation of [MMP-9] expression . Negative_regulation MMP9 EPHB2 20491781 2288867 Both and JNK inhibitors significantly *inhibited* hypoxia induced expression of 67LR and the subsequent expression of uPA and [MMP 9] . Negative_regulation MMP9 EPHB2 21567393 2562202 Regulation of by their specific siRNAs and pharmacologic inhibitors *prevented* glucose induced activation of [MMP9] in retinal endothelial cells . Negative_regulation MMP9 EPHB2 22138288 2530511 Activation of the Ras , Raf-1 , MEK , ERK , and NF-?B signaling pathway after CCL2 treatment was demonstrated , and CCL2 induced expression of [MMP-9] and migration activity were *inhibited* by the specific inhibitor , and mutant of Ras , Raf-1 , MEK , , and NF-?B cascades . Negative_regulation MMP9 EPHB2 22572236 2603579 In the presence of preparations of d 7-dry secretion of cows , the short-term release of [MMP-9] from bovine peripheral neutrophils was significantly ( P < 0.05 ) blocked by inhibitor of p38 MAPK but was significantly ( P < 0.05 ) *promoted* by inhibitor while TNF-a antibody or JNK inhibitor exerted no effect . Negative_regulation MMP9 FAS 11980895 954093 bcl-2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented *mediated* loss of [MMP] and cytochrome c release . Negative_regulation MMP9 FOXO1 24705809 2942985 In a loss of function , expression of a constitutive nuclear form of significantly *inhibited* [MMP9] activation induced by EGF . Negative_regulation MMP9 FOXO1 24771221 2944459 An expression of a constitutive nuclear form of significantly *inhibited* [MMP9] activation induced by EGF . Negative_regulation MMP9 HBEGF 17322418 1747794 Inhibition of heparin binding EGF-like growth factor ( ) release by CRM-197 and *inhibition* of [matrix metalloproteinases (MMP)] by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation . Negative_regulation MMP9 ID1 22301282 2580343 Targeting and NF-?B/p65 mRNA with shRNA in CNE-2 cells *inhibited* [MMP-9] expression and decreased the migratory capacity of CNE-2 cells . Negative_regulation MMP9 IL1B 10734001 678604 In vitro activation of CNS endothelium with the pro-inflammatory cytokines , tumour necrosis factor-alpha and , *resulted* in selective upregulation of [MMP-9] activity , whereas no significant changes were seen in MMP-2 or TIMP-2 levels at 24 h . Negative_regulation MMP9 IL1B 15037119 1224004 In this study , we have investigated the *roles* of and mitogen activated protein kinases in [MMP-9] induction in the retina . Negative_regulation MMP9 IL1B 15458430 1301528 TNF-alpha but not *resulted* in a dose dependent increase in the latent form of [MMP-9] . Negative_regulation MMP9 IL1B 15458430 1301532 Activation of the extracellular signal regulated protein kinase ( ERK1/2 ) MAPK mediated the up-regulation of MMP-9 by TNF-alpha whereas p38 was found to be involved in the mediated *inhibition* of TNF-alpha stimulated [MMP-9] . Negative_regulation MMP9 IL1B 16122880 1461097 A dose dependent inhibition of and TPA *stimulated* [MMP] activity by gallium nitrate at increasing concentrations occurs , demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis . Negative_regulation MMP9 IL1B 16939904 1609340 To investigate the *role* of in regulating the expressions of [matrix metalloproteinase-9 (MMP-9)] and tissue inhibitor of matrix metalloproteinase-3 ( TIMP-3 ) in cultured human endometrial cells of the mid-secretory phase . Negative_regulation MMP9 IL1B 17709570 1783234 In these cells , IL1R2 expression was markedly reduced , compared with non transfected cells or cells transfected with the empty vector , and there was a significant increase in the basal and the *induced* levels of matrix metalloproteinase (MMP)-2 and [MMP-9] secretion . Negative_regulation MMP9 IL1B 17890880 1811210 TNF-alpha but not *resulted* in a dose dependent increase in the latent form of [MMP-9] and a decrease in TIMP-1 production . Negative_regulation MMP9 IL1B 18782565 1975921 Sinomenine suppressed the production of proinflammatory cytokines and IL-6 in serum , *inhibited* the protein expressions and activities of MMP-2 and [MMP-9] , and elevated the protein expressions and activities of TIMP-1 and TIMP-3 in rat paw tissues . Negative_regulation MMP9 IL1B 19287189 2046594 Furthermore , HIV-1 Tat induced expression of [MMP-9] was significantly *inhibited* by neutralization of TNF-alpha , but not and IL-6 . Negative_regulation MMP9 IL1B 9639100 514017 Both and tumor necrosis factor alpha *induced* a 4- to 9-fold increase in the level of [MMP-9] expression in conditioned media , and a 17- to 24-fold increase in MMP-3 mRNA . Negative_regulation MMP9 MAP2K6 11716547 881765 While dominant negative p38 and mutants *reduced* [MMP-9] promoter activity in CAT assays , a construct encoding an activating mutation in the MKK-6 protein potently stimulated it . Negative_regulation MMP9 MAP2K6 19371720 2074654 The TGF-beta1 induced [MMP-9] expression was attenuated in the *presence* of either or Smad 3 inhibitor . Negative_regulation MMP9 MAP2K6 20413683 2267629 An EGF receptor (EGFR) kinase inhibitor , a RasN17 dominant negative construct , and PI3K inhibitors significantly *blocked* EGF/EGFR stimulated [MMP-9] , cell invasion , and colony formation in U1242 MG cells , suggesting that MMP-9 is involved in EGFR/Ras/MEK and PI3K/AKT signaling pathway mediated cell invasion and anchorage independent growth in U1242 MG cells . Negative_regulation MMP9 MAP2K6 21567393 2562208 Regulation of by their specific siRNAs and pharmacologic inhibitors *prevented* glucose induced activation of [MMP9] in retinal endothelial cells . Negative_regulation MMP9 MAP2K6 8631874 361312 However , the expression of a kinase-deficient 1 ( MEK1 ) did not *prevent* activation of the [92-kDa gelatinase] B promoter by ras and a constitutively activated c-raf expression vector was insufficient for 92-kDa gelatinase B promoter activation . Negative_regulation MMP9 MMP28 16400010 1506390 Importantly , co-treatment with two different , the broad spectrum inhibitor GM6001 and an [MMP-2/9-specific] *inhibitor* , suppressed TGFbeta induced ASC changes , including the epithelial-mesenchymal transformation of lens epithelial cells . Negative_regulation MMP9 MMP28 16940349 1609371 Importantly , the expression of also *resulted* in upregulation of MT1-MMP and [gelatinase-B] ( MMP-9 ) and in the collagen invasive activity of A549 cells . Negative_regulation MMP9 MMP28 17566014 1792191 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( MEK ) inhibitor , inhibited the enhanced invasiveness and activity of [MMP-9] and MMP-in these cells *induced* by CsA . Negative_regulation MMP9 MMP28 19178594 2105807 The active metabolite of vitamin D , 1alpha,25-dihydroxyvitamin D ( 3 ) [ 1alpha,25 ( OH ) ( 2 ) D ( 3 ) ] , has previously been reported to *inhibit* secretion of [MMP-9] in human monocytes ( MN ) , but its influence on the secretion and gene expression of and tissue inhibitors of MMP (TIMP) in M. tuberculosis infected cells has not previously been investigated . Negative_regulation MMP9 MMP28 19418307 2075866 Overall activity was augmented in both transplanted groups , but CsA *reduced* [MMP-9] activity and MMP-14 production . Negative_regulation MMP9 MMP28 22742512 2691633 We also investigated the capacity of these compounds to reduce cytokine and secretion by lipopolysaccharide (LPS) stimulated macrophages and to *inhibit* [MMP-9] activity . Negative_regulation MMP9 MMP7 16400010 1506405 Importantly , co-treatment with two different , the broad spectrum inhibitor GM6001 and an [MMP-2/9-specific] *inhibitor* , suppressed TGFbeta induced ASC changes , including the epithelial-mesenchymal transformation of lens epithelial cells . Negative_regulation MMP9 MMP7 17566014 1792206 CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ) , as well as the messenger RNA , protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and , a mitogen activated protein/extracellular signal regulated kinase ( MEK ) inhibitor , inhibited the enhanced invasiveness and activity of [MMP-9] and MMP-in these cells *induced* by CsA . Negative_regulation MMP9 MMP7 19178594 2105822 The active metabolite of vitamin D , 1alpha,25-dihydroxyvitamin D ( 3 ) [ 1alpha,25 ( OH ) ( 2 ) D ( 3 ) ] , has previously been reported to *inhibit* secretion of [MMP-9] in human monocytes ( MN ) , but its influence on the secretion and gene expression of and tissue inhibitors of MMP (TIMP) in M. tuberculosis infected cells has not previously been investigated . Negative_regulation MMP9 MMP7 19418307 2075881 Overall activity was augmented in both transplanted groups , but CsA *reduced* [MMP-9] activity and MMP-14 production . Negative_regulation MMP9 MMP7 22742512 2691648 We also investigated the capacity of these compounds to reduce cytokine and secretion by lipopolysaccharide (LPS) stimulated macrophages and to *inhibit* [MMP-9] activity . Negative_regulation MMP9 PLAT 22244977 2564150 We subjected mice to 6-h filamental middle cerebral artery occlusion ( MCAO ) with vehicle , delayed alone , or combined tPA ( 10 mg/kg , i.v. ) plus GM6001 ( 100 mg/kg , i.p. ) , a broad-spectrum [MMP] *inhibitor* . Negative_regulation MMP9 PLAU 12117412 997469 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Negative_regulation MMP9 PLAU 16474166 1548355 Moreover , Syk and Lck play differential roles in regulating Sp1 activation and expressions of melanoma cell adhesion molecule (MelCAM) , ( uPA ) , matrix metalloproteinase-9 (MMP-9) , and vascular endothelial growth factor ( VEGF ) in response to H/R. Overexpression of wild type Syk *inhibited* the H/R induced uPA , [MMP-9] , and VEGF expression but up-regulated MelCAM expression . Negative_regulation MMP9 PLAU 19330806 2080413 Moreover , we found that as well as uPAR induced the production of VEGF and MMP-9 , and that the down-regulation of uPA/uPAR by siRNAs or B-DIM treatment *resulted* in the inhibition of VEGF and [MMP-9] secretion which could be responsible for the observed inhibition of cell migration . Negative_regulation MMP9 PLAU 19693769 2150955 Our results , therefore , suggest that B-DIM down-regulates in aggressive breast cancers but in the absence of uPA-uPAR , B-DIM can directly *inhibit* VEGF and [MMP-9] leading to the inhibition of cell growth and migration of breast cancer cells . Negative_regulation MMP9 PLAU 20716639 2317898 receptor and/or [matrix metalloproteinase-9] *inhibition* induces apoptosis signaling through lipid rafts in glioblastoma xenograft cells . Negative_regulation MMP9 PLAU 24418973 2942391 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and TIMP-2 in the conditioned media . Negative_regulation MMP9 TFPI2 20015200 2489015 Moreover , down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in a ( 1 ) integrin on cell surface , and *increased* [MMP] expression ( mainly MMP-1 and -3 ) contributing to cancer cell invasion through basement membrane components . Negative_regulation MMP9 TGM2 18809380 1976249 Furthermore , overexpression *reduced* the [MMP-9] protein expression levels and inhibited its activity in both culture media and cell lysate . Negative_regulation MMP9 TGM2 18809380 1976252 These results suggest that *inhibits* [MMP-9] via downregulation of MMP-9 transcription activity by blocking the binding of the Jun-fos complex to an AP-1 site . Negative_regulation MMP9 TNF 10943866 721465 Suppression of alpha *induced* [matrix metalloproteinase 9] production by the introduction of a super-repressor form of inhibitor of nuclear factor kappaBalpha complementary DNA into immortalized human salivary gland acinar cells . Negative_regulation MMP9 TNF 10943866 721471 induced the production of MMP-9 in the ACpRc-1 cell clone , but greatly *suppressed* [MMP-9] production in ACMT-6 and ACMT-7 clones . Negative_regulation MMP9 TNF 11564820 863327 [MMP-9] release was first *detected* at 6 h and peaked at 22 h of incubation with activated T cell membranes , while release peaked after only 6 h. Anti-TNF-alpha mAb inhibited the T cell membrane induced MMP-9 release , indicating a possible autocrine regulation of MMP release by mast cell TNF-alpha . Negative_regulation MMP9 TNF 11813159 907415 Chemokines increased mRNA levels and protein release in monocytes and THP-1 cells , and neutralizing anti-TNF-alpha antibodies *inhibited* CCL2 induced [MMP-9] release . Negative_regulation MMP9 TNF 12105194 984534 Interferons ( IFNs ) inhibit [MMP-9] activation in *response* to , and the latter activates the MMP-9 gene through NF-kappaB . Negative_regulation MMP9 TNF 12506070 1038350 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in [MMP] and TIMP expression . Negative_regulation MMP9 TNF 14724072 1197979 Zymography , immunoblot , and northern blot analysis showed that [MMP-9] expression is significantly reduced in *response* to stimulation with increasing in vitro age . Negative_regulation MMP9 TNF 14984207 1214666 Furthermore , PTEN expression strongly decreased [MMP-9] promoter activity in *response* to . Negative_regulation MMP9 TNF 15145598 1247713 We investigated the pharmacokinetics and the effect of , a water-soluble hydroxamate based *inhibitor* of [MMP] and TACE , on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis . Negative_regulation MMP9 TNF 15175338 1273492 Furthermore , GD3 synthase gene expression strongly decreased [MMP-9] promoter activity in *response* to . Negative_regulation MMP9 TNF 15458430 1301527 but not IL-1beta *resulted* in a dose dependent increase in the latent form of [MMP-9] . Negative_regulation MMP9 TNF 15513534 1328329 The addition of FP caused significant suppression of [MMP-2 and -9] production from nasal polyp fibroblasts in *response* to stimulation . Negative_regulation MMP9 TNF 15663564 1350386 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Negative_regulation MMP9 TNF 16106101 1445006 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Negative_regulation MMP9 TNF 16106101 1445030 TR at more than 5 x 10 ( -5 ) M inhibited the production of MMP-2 and [MMP-9] from NF in *response* to stimulation , whereas TIMP-1 and TIMP-2 production was scarcely affected . Negative_regulation MMP9 TNF 16816114 1580954 In addition , we found that treatment with antioxidants reversed the decreased [matrix metalloproteinase-9 (MMP-9)] expression in *response* to as determined by zymography and immunoblot in GD3 synthase gene transfectants . Negative_regulation MMP9 TNF 17469134 1737500 OSM and stimulated MMP expression as visualized by zymography , and [MMP] expression was dose-dependently *inhibited* by forskolin and IBMX . Negative_regulation MMP9 TNF 17570325 1753753 Moreover , magnolol treatment strongly decreased [MMP-9] promoter activity in *response* to . Negative_regulation MMP9 TNF 17890880 1811209 but not IL-1 beta *resulted* in a dose dependent increase in the latent form of [MMP-9] and a decrease in TIMP-1 production . Negative_regulation MMP9 TNF 18556801 1940710 In vitro , PPARgamma agonists reduced IL-8 and [MMP-9] release from airway epithelial cells in *response* to PAO1 or stimulation . Negative_regulation MMP9 TNF 19281093 2007632 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Negative_regulation MMP9 TNF 21112094 2372185 *increased* EVT apoptosis , decreased villous cytotrophoblast proliferation and increased expression of [pro-MMP-9] ( but not active MMP-9 ) , urokinase plasminogen activator (uPA) and plasminogen activator inhibitor (PAI)-1 by EVT . Negative_regulation MMP9 TNF 22202225 2519012 In addition , we aimed to establish cytokine-chemokine networks in the cellular media and the modulation of cytokines such as ( TNF-B ) , interferon-alpha ( IFN-a ) , transforming growth factor-beta (TGF-B) , interleukins ( IL ) such as IL1-B and IL-6 , as well as [matrix metalloproteinases (MMP)] and tissue *inhibitors* of metalloproteinases ( TIMP ) . Negative_regulation MMP9 TNF 22353423 2586873 In vitro , results based on cultured DRG neurons showed that siRNA mediated inhibition of NOV enhanced IL-1ß- and induced MMP-2 , MMP-9 and CCL2 expression whereas NOV addition *inhibited* TNF-a induced [MMP-9] expression through ß1 integrin engagement . Negative_regulation MMP9 TNF 22710949 2687013 Furthermore , stimulated MMP-2 and MMP-9 activities in a dose dependent manner , but either knockdown of focal adhesion kinase ( FAK ) by short interference RNA or inhibition of extracellular regulated protein kinase ( ERK ) by chemical inhibitor could *block* TNF-a stimulated MMP-2 and [MMP-9] activities in vitro . Negative_regulation MMP9 TNF 23341882 2733873 PDTC significantly inhibited the expression of [MMP9] and the phosphorylation of I?Ba , as well as the expression of phosphorylation p65 protein in *response* to ( p < 0.05 ) . Negative_regulation MMP9 TNF 24193164 2879321 Both active and latent forms of [MMP-9] gelatinolytic activity were significantly *increased* by ( 96 h ) and LPS ( 72 and 96 h ) . Negative_regulation MMP9 TNF 9130458 426865 This study examined the *role* of IFN-gamma and ( + ) in the regulation of the matrix metalloproteinases , MMP-2 ( 72 kD gelatinase A ) and [MMP-9] ( 92 kD gelatinase B ) . Negative_regulation MMP9 TNFSF10 23582782 2778441 however , the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus *induced* loss of [MMP] and apoptosis . Negative_regulation MNAT1 CAPN8 16407116 1513335 Increased activity in sensory neurons after inflammation *resulted* in the cleavage of [p35] to p25 , which forms a more stable complex with Cdk5 and , consequently , leads to elevation of Cdk5 activity . Negative_regulation MOB1A CLU 17359935 1712669 Presence of *reduced* NF-kappaB activation and expression of the NF-kappaB target genes TNF-alpha and [MOB-1] under cell stress . Negative_regulation MOCOS IL1B 8315884 222875 also transcriptionally *increased* the mRNA levels for alpha 1 ( I ) alpha 1 ( IV ) collagens and fibronectin in the non stimulated MCs , however , inhibited the increase of these mRNA levels in the TGF-beta treated [MCs] . Negative_regulation MOG FUT4 19608865 2112244 In vitro , inhibited local C5a/C3a production by antigen presenting cell-T-cell complexes and *attenuated* [MOG] ( 35-55 ) -specific Th1 and Th17 responses with little nonspecific cytotoxicity . Negative_regulation MOG IL1B 16109311 1445237 Interestingly , both and TNF-alpha markedly *inhibited* the expression of [MOG] , CNPase , and PLP but not MBP , the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate ( PDTC ) . Negative_regulation MOG TNF 16109311 1445236 Interestingly , both IL-1beta and markedly *inhibited* the expression of [MOG] , CNPase , and PLP but not MBP , the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate ( PDTC ) . Negative_regulation MOK EPHB2 22699121 2626585 The negative regulation of [RAGE] on cell proliferation *results* from suppression of Wnt , PI3K and signaling , and is restored by RAGE neutralizing antibody . Negative_regulation MOK S100B 18331229 1840134 Oligomerization of S100 proteins under the non reducing , high-Ca2+ conditions found extracellularly appears to play a relevant role in RAGE activation , and binding of at least S100A12 and *results* in [RAGE] oligomerization . Negative_regulation MOK S100B 21889514 2539103 In [RAGE] overexpressing myocytes , ( 100 nM ) *resulted* in increases in VEGF mRNA , VEGF protein , VEGF secretion , and activation of the transcription factor NF-?B . Negative_regulation MOK TNF 22418033 2582642 Danshensu partly blocked the expression of [RAGE] , p-p38 , and COX-2 , and NF-?B activation , and *inhibited* the increase of , IL-6 , and PGE2 . Negative_regulation MPO ARSA 18703751 1968069 [MPO] activity was decreased significantly in *response* to monotherapy with 5-ASA and each of the antioxidants plus <5-ASA> when compared to TNBS . Negative_regulation MPO BPI 2539411 108523 In contrast , [myeloperoxidase] binding to E. coli is strongly *inhibited* by . Negative_regulation MPO HES2 19166983 2038554 In addition , both and BL could *attenuate* the increase in TNF-alpha , IL-6 , [MPO] levels and NF-kappaB activation . Negative_regulation MPO SMN2 25050315 2948669 Biochemical analyses revealed that and CLX individually and in combination therapy could *reduce* the MMF increased nitric oxide ( NO ) content , [myeloperoxidase (MPA)] activity , and malondialdehyde ( MDA ) level , while the MMF reduced level of total thiol molecules ( TTM ) was increased significantly ( p < 0.05 ) by given compounds . Negative_regulation MPO TNF 10699463 672114 *Role* of in regulation of [myeloperoxidase] expression in irradiated HL60 promyelocytic cells . Negative_regulation MPO TNF 16883632 1594738 Shen-Fu ( 10,100 mg/kg ) decreased [MPO] activity and wet/dry weight ratio and *inhibited* and IL-6 production , endotoxin induced NF-kappa B activation . Negative_regulation MPO TNF 21070844 2376544 IG significantly ameliorated macroscopic damage and histological changes , reduced the activity of [MPO] , depressed MDA and NO levels and effectively *inhibited* the protein and mRNA expressions of NF-?Bp65 , and IL-6 in the colon tissues of experimental colitis in a dose dependent manner . Negative_regulation MPO TNF 21316771 2489341 NaHS significantly reduced the myocardial infarct size ( 31.2 ± 4.7 % ) , *inhibited* the production of lipid peroxidation , [MPO] activity , and cell apoptosis , and downregulated expression of caspase-3 , Fas , FasL , and , which had been elevated by MIR , while PAG further increased the myocardial infarct size ( 58.3 ± 5.9 % ) , and displayed opposite effects . Negative_regulation MPO TNF 9283718 451787 reduced serum ( 25 +/- 5 u ml-1 vs 379 +/- 16 u ml-1 ) , ameliorated leukopaenia and *reduced* ileal [MPO] ( 0.7 +/- 0.02 u 10 ( -3 ) g-1 tissue vs 4.2 +/- 0.4 u 10 ( -3 ) g-1 tissue ) . Negative_regulation MPO TNF 9609097 508729 Reverse transcription-polymerase chain reaction and immunohistochemical techniques were used to demonstrate that 24 h to 1 wk after UVB-light irradiation , PTX inhibited UVB induced TNF-alpha gene expression , *inhibited* the increase in epidermal protein synthesis , blocked the increase in epidermal proliferation observed after exposure to UVB light , and decreased production of [myeloperoxidase] by neutrophils infiltrating into the dermis . Negative_regulation MPZ MAOA 3875815 50643 The formation of [ 3H ] [MPP+] in human platelets is *prevented* by specific MAO-B but not by or by 5-hydroxytryptamine uptake inhibitors . Negative_regulation MPZ NGFR 7536747 300266 In the case of purified Schwann cells , treatment with TGF-beta 1 increases their proliferation , and it promotes a pre- or nonmyelinating Schwann cell phenotype characterized by increased NCAM expression , decreased expression , *inhibition* of the forskolin mediated induction of the [myelin protein P0] , and induction of the Schwann cell transcription factor suppressed cAMP-inducible POU protein . Negative_regulation MRAS EPHB2 15735740 1389711 Inhibition of either or PI3 kinase *blocked* the capacity of both activated [M-Ras] and activated H-Ras to support proliferation and viability . Negative_regulation MRC1 TNF 16941682 1609447 Increased hepatic and iNOS expression might *enhance* peroxynitrite formation and inhibition of [MRC] complexes . Negative_regulation MRC2 TNF 16941682 1609445 Increased hepatic and iNOS expression might *enhance* peroxynitrite formation and inhibition of [MRC] complexes . Negative_regulation MRE11A DGKI 15894621 1411629 regulates Ras guanyl releasing protein 3 and *inhibits* [Rap1] signaling . Negative_regulation MRE11A DGKI 15894621 1411655 We demonstrate that bound to RasGRP3 and *inhibited* its activation of [Rap1] by metabolizing DAG . Negative_regulation MRE11A MAP2K6 17646383 1793403 The downregulation of [Rap1GAP] by Ras *required* the activation of the signal regulated kinase cascade and was correlated with the induction of mesenchymal morphology and migratory behavior . Negative_regulation MRXS5 ARSA 11740295 886784 The purpose of this study was to analyze the effects of , an *inhibitor* of [PGs] synthesis , in the pituitary responses to physical stress in humans . Negative_regulation MS CD14 17046070 1649381 The aim of this study was to evaluate a possible *role* of soluble ( sCD14 ) in [multiple sclerosis (MS)] . Negative_regulation MS CLU 7730444 302329 Thus , TGF-beta 1 and heterotypic cell interactions influence clusterin expression by astrocytes and may be important to the *role* of in [multiple sclerosis] , AIDS , and Alzheimer 's disease . Negative_regulation MS MMP28 12620642 1066246 In [multiple sclerosis (MS)] , activity in tissues is the *result* of a balance between MMPs and their tissue inhibitors ( TIMPs ) . Negative_regulation MS MMP7 12620642 1066261 In [multiple sclerosis (MS)] , activity in tissues is the *result* of a balance between MMPs and their tissue inhibitors ( TIMPs ) . Negative_regulation MS TLR7 19837184 2216963 An increasing body of circumstantial evidence implicates a *role* of signalling in systemic lupus erythematosus ( SLE ) , atherosclerosis , asthma , type 1 diabetes , [multiple sclerosis] , bowl inflammation and rheumatoid arthritis ( RA ) . Negative_regulation MS TNF 10652446 663191 The precise *role* of in [multiple sclerosis (MS)] is still controversial . Negative_regulation MSI1 ARSA 21436383 2421742 Previous cellular studies showed that aspirin ( acetylsalicylic acid : ASA ) and nitric oxide donating ASA ( ) *suppressed* [microsatellite instability (MSI)] in mismatch repair (MMR)-deficient cells linked to the common cancer predisposition syndrome hereditary nonpolyposis colorectal cancer or Lynch syndrome ( LS/HNPCC ) , at doses 300- to 3,000-fold less than ASA . Negative_regulation MSI2 ARSA 21436383 2421741 Previous cellular studies showed that aspirin ( acetylsalicylic acid : ASA ) and nitric oxide donating ( NO-ASA ) *suppressed* [microsatellite instability (MSI)] in mismatch repair (MMR)-deficient cells linked to the common cancer predisposition syndrome hereditary nonpolyposis colorectal cancer or Lynch syndrome ( LS/HNPCC ) , at doses 300- to 3,000-fold less than ASA . Negative_regulation MST1 STK39 10586055 571663 Here we demonstrate that expression of in RAW264.7 cells *resulted* in suppression of NO production following IFN-gamma+/- LPS stimulation in the presence of [MSP] , reflecting a decrease in the levels of inducible NO synthase (iNOS) mRNA and protein , which was confirmed by decreased trans-activation of an iNOS reporter . Negative_regulation MSTN FBXO32 22673621 2659017 Therefore , these results highlight the central *role* of in regulating [myostatin] signaling during myogenesis . Negative_regulation MSTN FOXO1 16885393 1672604 Here we examined the *role* of and SMAD transcription factors in regulating [myostatin] gene expression and myoblast differentiation in C ( 2 ) C ( 12 ) myotubes in vitro . Negative_regulation MSTN PGC 23217713 2707901 Rather , it specifically induces IGF1 and *represses* [myostatin] , and expression of in vitro and in vivo induces robust skeletal muscle hypertrophy . Negative_regulation MSX1 HDAC3 23506836 2776983 Murine craniofacial development requires *mediated* repression of [Msx] gene expression . Negative_regulation MSX1 ISL1 12900460 1118750 Inhibition of in distal epithelium *resulted* in a loss of Bmp4 expression and a corresponding loss of [Msx1] expression , indicating that a positive regulatory loop exists between ISL1 and BMP4 in distal epithelium . Negative_regulation MSX1 NBL1 11607250 177626 We also found that [MSX] *induced* dissimilatory reduction of to NH4+ in soil and that the NH4+ thus formed had no effect on the rate of NO-3 reduction . Negative_regulation MSX1 TGFB1 9870533 556746 We also demonstrate that *inhibits* [Msx-1] mRNA expression in palate mesenchymal cells , with retinoic acid and transforming growth factor beta acting synergistically when added simultaneously to these cells . Negative_regulation MSX1 TGFB2 9870533 556747 We also demonstrate that *inhibits* [Msx-1] mRNA expression in palate mesenchymal cells , with retinoic acid and transforming growth factor beta acting synergistically when added simultaneously to these cells . Negative_regulation MSX1 TGFB3 9870533 556748 We also demonstrate that *inhibits* [Msx-1] mRNA expression in palate mesenchymal cells , with retinoic acid and transforming growth factor beta acting synergistically when added simultaneously to these cells . Negative_regulation MT-CO2 CA12 15258031 1272393 The effects of indomethacin , [CO(2)] breathing ( 3 % ) before and after indomethacin treatment , and *inhibition* with or without indomethacin treatment were investigated . Negative_regulation MT-CO2 CA12 15258031 1272419 After indomethacin had been given , the rise in ONPO ( 2 ) caused by [CO(2)] breathing and *inhibition* was significantly reduced . Negative_regulation MT-CO2 CA12 15708831 1373257 inhibition reduces the removal of CO2 from the tissue and the [CO2] accumulation *induces* vasodilatation resulting in increased blood flow and improved oxygen supply . Negative_regulation MT-CO2 CA12 3115121 77588 We studied the *roles* of gill and erythrocyte in normal [CO2] transfer ( metabolic CO2 elimination ) and in HCO3- excretion during metabolic alkalosis in the resting and swimming dogfish shark , Squalus acanthias . Negative_regulation MT-CO2 CA12 6772280 11575 The results suggest the need for reinterpretation of some concepts about the *role* of in [CO2] accumulation in the brain . Negative_regulation MT-CO2 CA12 8002517 283865 *Roles* of intra- and extracellular in alveolar-capillary [CO2] equilibration . Negative_regulation MT-CO2 CA12 9227587 443324 An isolated , perfused tail preparation was used to study the *role* of in [CO2] and NH3 transport across the sarcolemma of white muscle in the rainbow trout . Negative_regulation MT-CO2 CA12 9987639 560268 These findings suggest that the inhibition of activity by AZ , which decreases the rate of CO2 conversion to HCO3- , *causes* the retention of [CO2] in tissues and organs , and thus increases BF in specific organs . Negative_regulation MT-CO2 TNF 20397120 2240586 [CO (2)] , but not hypoxia , *induced* a significant reduction in the release of and IL-8 as well as a significant increase in the release of IL-10 and IL-1 beta within the first 4 h after incubation . Negative_regulation MT-CYB TNF 10788444 688691 *increases* the steady-state reduction of [cytochrome b] of the mitochondrial respiratory chain in metabolically inhibited L929 cells . Negative_regulation MT-TP TNF 19593846 2105370 Quantitative real-time PCR assays showed that CE treatment decreased the mRNA expression of IL-1beta , IL-6 and , improved the mRNA expression of IR , IRS1 , IRS2 , PI3K and Akt1 , *inhibited* CD36 , [MTTP] , and PTEN , and enhanced the impaired SREBP-1c expression in TNF-alpha treated enterocytes . Negative_regulation MT1JP MSX1 16451220 1522006 In transient transfection experiments , potently *inhibited* pituitary homeobox-1 (Pitx-1) induced [MT(1)] promoter activity and therefore may represent a key inhibitor of MT(1) expression in early pituitary development . Negative_regulation MT3 CST6 22802712 2628693 Among the genes identified in non stressed roots only were Ser/Thr protein kinases , wound induced basic protein , ethylene-responsive family protein , [metallothionein-like] protein cysteine proteinase *inhibitor* ( ) and Putative Kunitz trypsin protease inhibitor . Negative_regulation MT3 GJB2 9115588 423508 In addition , FA strongly induced [metallothionein] 1 expression and *inhibited* expression in skin but did not affect expression of these genes in tumors . Negative_regulation MT4 CST6 22802712 2628683 Among the genes identified in non stressed roots only were Ser/Thr protein kinases , wound induced basic protein , ethylene-responsive family protein , [metallothionein-like] protein cysteine proteinase *inhibitor* ( ) and Putative Kunitz trypsin protease inhibitor . Negative_regulation MT4 GJB2 9115588 423505 In addition , FA strongly induced [metallothionein] 1 expression and *inhibited* expression in skin but did not affect expression of these genes in tumors . Negative_regulation MTOR CAPN8 23467348 2749988 In rat hippocampal slices , cortical synaptoneurosomes , and cultured neurons , BDNF induced [mTOR] pathway *activation* and protein translation were blocked by inhibition . Negative_regulation MTOR DAPK1 18974095 2015065 DAPK ( +/- ) mouse embryo fibroblasts have attenuated [mTORC1] signaling compared with DAPK+/+ counterparts , and overexpression of in DAPK ( +/- ) MEFs *stimulates* mTORC1 activity . Negative_regulation MTOR EPHB2 21494688 2418135 Morphoproteomic analysis revealed that the mTOR pathway was activated in these two patients with advanced Ewing 's sarcoma who showed response to combined IGF1R and [mTOR] *inhibition* , and the pathway in the patient in whom resistance to this combination emerged . Negative_regulation MTOR EPHB2 22715163 2634071 Lovastatin alone significantly reduced MPC and MTT cell viability at therapeutically relevant doses and *inhibited* both and AKT signalling , but increased [mTORC1/p70S6K] signalling . Negative_regulation MTOR EPHB2 23431403 2744411 Absence of kinase suppressor of Ras 1 (KSR1) , a scaffold protein of the ERK signaling pathway , or inhibition of *resulted* in decreased [mTORC1] activity following T cell activation . Negative_regulation MTOR EPHB2 23966835 2832403 Inhibition of mGluR5 or signaling *restores* appropriate [mTOR-dependence] to LTD , and significantly reduces epileptiform bursting in TSC2 ( +/- ) hippocampal slices . Negative_regulation MTOR FBXO32 24002653 2856130 Smad3 induces , *inhibits* [mTOR] and protein synthesis , and promotes muscle atrophy in vivo . Negative_regulation MTOR FBXO32 24002653 2856152 To accomplish this goal , in vivo transfection of plasmid DNA was used to create transient transgenic mouse skeletal muscles , and our results show for the first time that Smad3 expression is sufficient to stimulate promoter activity , *inhibit* [Akt/mTOR signaling] and protein synthesis , and induce muscle fiber atrophy . Negative_regulation MTOR FOXO1 20412774 2246454 Activated *inhibits* [mTORC1] by TSC2 dependent and TSC2 independent mechanisms . Negative_regulation MTOR FOXO1 20412774 2246474 Thus , under stress conditions , *inhibits* the anabolic activity of [mTORC1] , a major consumer of cellular energy , while activating Akt , which increases cellular energy metabolism , thereby maintaining cellular energy homeostasis . Negative_regulation MTOR FOXO1 22820375 2640261 activation *resulted* in [mTOR] inhibition by preventing the translocation of mTOR to lysosomal membranes in a glutamine-synthetase dependent manner . Negative_regulation MTOR FOXO1 23800068 2802912 This hypothesis postulates that antiacne agents either enhance nuclear activity or *inhibit* [mTORC1] . Negative_regulation MTOR GNE 20346656 2231148 Identification of , a potent and efficacious dual [PI3K/mTOR] *inhibitor* . Negative_regulation MTOR GNE 20346656 2231151 This discovery led to the identification of ( 8 ) , a potent and efficacious dual [PI3K/mTOR] *inhibitor* . Negative_regulation MTOR MAP2K6 17013836 1647631 While inhibition by PD98059 and [mTOR] *inhibition* by rapamycin affected the cyclin D1 nuclear shift and cell proliferation to a lesser extent , both these inhibitors reduced cyclin D1 levels . Negative_regulation MTOR MAP2K6 21630605 2437037 The skin toxicity profile of EGFR *inhibitors* , en Raf inhibitors , [mTOR] inhibitors , VEGF targeting molecules , multikinase inhibitors , the HER2 monoclonal antibody trastuzumab and the CTLA-4 monoclonal antibodies are discussed . Negative_regulation MTOR MAP2K6 22553342 2614095 Apollon modulation and melanoma apoptosis were evaluated by Western blot and/or flow cytometry in response to cytotoxic drugs , mitogen activated protein/extracellular signal regulated kinase ( ) - , BRAF ( V600E ) - , and [mTOR-specific] *inhibitors* , TRAIL and anti-HLA class II monoclonal antibodies ( mAb ) . Negative_regulation MTOR MAP2K6 22808163 2628932 Instead , cooperative [mTOR complex 2 (mTORC2)] and *inhibition* resulting in downregulation of the pro-survival protein MCL-1 was found to be critical for combination induced apoptosis . Negative_regulation MTOR MAP2K6 24652289 2934680 Nearly all IRS1 Ser(P)/Thr ( P ) residues were stimulated by insulin and significantly suppressed by PI3K inhibition ; fewer were suppressed by Akt or [mTOR] inhibition , and none were *suppressed* by inhibition . Negative_regulation MTOR PADI3 22605338 2632266 Anticancer inhibitors *regulate* the autophagy flux and the [mammalian target of rapamycin] complex 1 activity . Negative_regulation MTOR TLR7 24251781 2903755 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , PI3K/AkT inhibition , IKK/JNK inhibition , [mTORC1] *inhibition* , JAK/STAT inhibition , suppression , and ACE inhibition . Negative_regulation MTOR TNFSF10 21666560 2442730 Especially EGFR mutations , anti-angiogenesis , multi kinase inhibition , vascular disrupting agents , vaccines , [m-TOR] inhibitors , *inhibition* and several biomarkers are highlighted including current study results . Negative_regulation MTTP ALOX5 18645210 1984495 Furthermore , <5-LO> inhibition *restored* hepatic [microsomal TG transfer protein (MTP)] activity in parallel with a stimulation of hepatic VLDL-TG and apoB secretion in ob/ob mice . Negative_regulation MTTP ALOX5 18645210 1984496 Consistent with these findings , <5-LO> products directly *inhibited* [MTP] activity and triggered cytosolic TG accumulation in CC-1 cells , a murine hepatocyte cell line . Negative_regulation MTTP NR2F1 22357705 2581432 However , mechanisms involved in the *repression* of [MTP] by were not elucidated . Negative_regulation MTX1 ABCG2 21566011 2453957 The absence of Abcc2 and/or also *led* to significantly increased liver and kidney levels of [7OH-MTX] . Negative_regulation MTX1 TNF 23869169 2817617 Overall these trials demonstrated that TCZ was effective in the treatment of RA in a number of patient groups , including those with an inadequate response to [methotrexate (MTX)] or *inhibition* . Negative_regulation MUC1 EPHB2 16983494 1617435 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Negative_regulation MUC1 EPHB2 17146999 1497071 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC1 IL1B 12869928 1112232 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Negative_regulation MUC1 MAP2K6 17146999 1497077 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC1 MUC16 9427605 481669 This [MUC1] *induced* suppression of T-cell responses can be reversed by the addition of exogenous IL-2 or anti-CD28 monoclonal antibody . Negative_regulation MUC1 SCIN 15342343 1353789 ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* [mucin] secretion . Negative_regulation MUC1 SPHK1 19835973 2203053 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Negative_regulation MUC1 TNF 12441351 1037230 [MUC1] release was stimulated by phorbol 12-myristate 13-acetate and was markedly *inhibited* by the synthetic peptide hydroxamate metalloprotease inhibitor , protease inhibitor ( TAPI ) , as well as by an endogenous inhibitor of matrix metalloproteases , tissue inhibitor of metalloproteases ( TIMP ) -3 . Negative_regulation MUC1 TNF 1826697 155270 In addition , G-CSF binding studies suggested that the *induced* decrease in G-CSF binding to [PEM] was probably due to a reduction in receptor number rather than receptor affinity . Negative_regulation MUC12 EPHB2 16983494 1617437 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Negative_regulation MUC12 EPHB2 17146999 1497080 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC12 IL1B 12869928 1112233 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Negative_regulation MUC12 MAP2K6 17146999 1497086 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC12 SCIN 15342343 1353790 ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* [mucin] secretion . Negative_regulation MUC12 SPHK1 19835973 2203055 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Negative_regulation MUC13 EPHB2 16983494 1617439 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Negative_regulation MUC13 EPHB2 17146999 1497089 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC13 IL1B 12869928 1112234 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Negative_regulation MUC13 MAP2K6 17146999 1497095 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC13 SCIN 15342343 1353791 ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* [mucin] secretion . Negative_regulation MUC13 SPHK1 19835973 2203057 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Negative_regulation MUC15 EPHB2 16983494 1617423 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Negative_regulation MUC15 EPHB2 17146999 1497001 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC15 IL1B 12869928 1112226 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Negative_regulation MUC15 MAP2K6 17146999 1497007 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC15 SCIN 15342343 1353768 ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* [mucin] secretion . Negative_regulation MUC15 SPHK1 19835973 2203041 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Negative_regulation MUC16 AKT1 16443643 1567289 PPAR-gamma agonists or specific inhibitors of phosphoinositide 3-kinase exert inhibition of cigarette smoke *induced* [mucin] production , with the upregulation of PTEN signaling and downregulation of expression . Negative_regulation MUC16 AKT2 16443643 1567290 PPAR-gamma agonists or specific inhibitors of phosphoinositide 3-kinase exert inhibition of cigarette smoke *induced* [mucin] production , with the upregulation of PTEN signaling and downregulation of expression . Negative_regulation MUC16 AKT3 16443643 1567291 PPAR-gamma agonists or specific inhibitors of phosphoinositide 3-kinase exert inhibition of cigarette smoke *induced* [mucin] production , with the upregulation of PTEN signaling and downregulation of expression . Negative_regulation MUC16 ATP5O 11885694 919845 Butanol fraction showed significant increase in [mucin] secretion , and *inhibited* malondialdehyde ( MDA ) and H+/ activity in the stomach . Negative_regulation MUC16 CA2 8178999 256060 Forskolin can stimulate [mucin] secretion in a Ca ( 2+ ) -independent manner but is apparently *inhibited* by high levels of intracellular induced by Ca2+ ionophores in 1.0 mM Ca2+ media . Negative_regulation MUC16 CASP3 12051697 950511 Moreover , inhibition of blocked the LPS induced increase in caspse-3 activity and produced an *increase* in [mucin] synthesis . Negative_regulation MUC16 CASP3 12587977 1029747 Moreover , inhibitor not only blocked the NO-induced increase in caspase-3 activity but also produced an *increase* in [mucin] synthesis . Negative_regulation MUC16 CEACAM5 9299249 453430 In two lines , SNU-8 and SNU-840 , an elevated level of [CA125] antigen secretion could be *detected* , whereas was undetectable in all five lines . Negative_regulation MUC16 CFTR 9831904 551544 Actions of adenosine A1 and A2 receptor antagonists on antibody *inhibited* beta-adrenergic [mucin] secretion response . Negative_regulation MUC16 CLCA1 17426222 1723905 In this study , we investigated the *role* of the putative calcium activated and its blocker , niflumic acid , in cigarette smoke induced [mucin] synthesis both in vivo and in vitro . Negative_regulation MUC16 CLCA1 18596559 1953690 Our goal was to investigate the effect of glucocorticosteroids , acetyl-cysteine (ACC) , and calcium activated inhibitors in a model of Th2 type cytokine *induced* [mucin] expression in human airway mucosa . Negative_regulation MUC16 CLCA2 18596559 1953691 Our goal was to investigate the effect of glucocorticosteroids , acetyl-cysteine (ACC) , and calcium activated inhibitors in a model of Th2 type cytokine *induced* [mucin] expression in human airway mucosa . Negative_regulation MUC16 CLCA4 18596559 1953692 Our goal was to investigate the effect of glucocorticosteroids , acetyl-cysteine (ACC) , and calcium activated inhibitors in a model of Th2 type cytokine *induced* [mucin] expression in human airway mucosa . Negative_regulation MUC16 CRK 17146999 1497009 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , MAP kinase inhibitors , MEK/ERK inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC16 EDN1 15347558 1333653 *inhibits* [mucin] secretion from ovine airway epithelial goblet cells . Negative_regulation MUC16 EGF 9419754 291232 We investigated quantitatively and immunohistochemically *stimulated* CA125 release from WISH cells and the effect of EGF on [CA125] phosphorylation . Negative_regulation MUC16 EGFR 11686870 875886 *Role* of activation in regulating [mucin] synthesis . Negative_regulation MUC16 EGFR 15516478 1328556 *Roles* of activation in epithelial cell repair and [mucin] production in airway epithelium . Negative_regulation MUC16 EGFR 15527548 1332428 Using [ ( 3 ) H ] glucosamine labeled mucous acinar cells of sublingual salivary gland in culture , we show that stimulatory effect of beta-adrenergic agonist , isoproterenol , on [mucin] secretion was *inhibited* in a concentration dependent manner by kinase inhibitor , PD153035 , as well as wortmannin , an inhibitor of PI3K . Negative_regulation MUC16 EGFR 15985706 1428856 Using [ ( 3 ) H ] glucosamine labeled gastric mucosal cells , we show that stimulatory effect of beta-adrenergic agonist , isoproterenol , on [mucin] secretion was *inhibited* by kinase inhibitor , PD153035 , as well as wortmannin , a specific inhibitor of PI3K . Negative_regulation MUC16 EGFR 17218812 1682094 activation causes mucin production and inhibition *prevents* [mucin] production by multiple stimuli . Negative_regulation MUC16 EGFR 21868713 2546707 This study assessed the *role* of signaling in mediating the effects of exposure to vesicants on the secretion of cytokines and production of [mucin] in human airway epithelial cells . Negative_regulation MUC16 EPHB2 16983494 1617425 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Negative_regulation MUC16 EPHB2 17146999 1497010 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC16 FOXA2 23915402 2866126 In addition , we used quantitative real time PCR , ELISA , immunofluorescence and mouse lung infection to assess whether the loss of function *caused* GCHM and [mucin] overexpression . Negative_regulation MUC16 GAD1 20448051 2381092 The nicotine induced increase in and GABA(A) receptor mRNA *resulted* in increased GABA induced currents and increased expression of [mucin] . Negative_regulation MUC16 GAL 1663364 173107 The binding of SSA-M to sialidase treated porcine [mucin] was *inhibited* strongly by GalNAc and disaccharides containing galactose ( lactose , melibiose , and N-acetyllactosamine ) but not by free , suggesting that the glycan for optimum binding is Gal beta ( 1-3 ) GalNAc . Negative_regulation MUC16 GNAS 24498386 2913880 By contrast , exogenous *inhibited* expression of [mucin] genes in PCI-35 and MIA PaCa-2 cells , despite upregulation of cAMP . Negative_regulation MUC16 IFNG 7515824 257283 We thus concluded that the target for *inhibition* of cAMP stimulated Cl.16E [mucin] secretion is distal to protein kinase A and might be a component of the exocytotic machinery . Negative_regulation MUC16 IFNG 8217487 231711 *suppressed* both [CA125] release and 125I labeled MoAb binding . Negative_regulation MUC16 IKBKB 17237423 1689982 A novel *role* for IkappaB kinase (IKK) alpha and in ERK dependent up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Negative_regulation MUC16 IL1B 12869928 1112227 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Negative_regulation MUC16 IL1B 8812537 383376 and TNF-alpha treatment of HPMCs *resulted* in a significant reduction in [CA-125] release ; Negative_regulation MUC16 IL4 11475334 841847 However , 15LOa products do not mediate the *induced* reduction in [mucin] secretion observed in this cell type . Negative_regulation MUC16 IL6 15016409 1220841 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Negative_regulation MUC16 MAP2K1 17146999 1497011 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC16 MAP2K2 17146999 1497012 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC16 MAP2K3 17146999 1497013 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC16 MAP2K4 17146999 1497014 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC16 MAP2K5 17146999 1497015 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC16 MAP2K6 17146999 1497016 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC16 MAP2K7 17146999 1497017 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC16 MAPK1 22977714 2674019 Rottlerin ( PKCd inhibitor ) inhibited PMA induced [MUC16] expression , and also *inhibited* the phosphorylation of activated p38 by PMA . Negative_regulation MUC16 MAPK10 22977714 2674020 Rottlerin ( PKCd inhibitor ) inhibited PMA induced [MUC16] expression , and also *inhibited* the phosphorylation of activated p38 by PMA . Negative_regulation MUC16 MAPK11 22977714 2674021 Rottlerin ( PKCd inhibitor ) inhibited PMA induced [MUC16] expression , and also *inhibited* the phosphorylation of activated p38 by PMA . Negative_regulation MUC16 MAPK12 22977714 2674022 Rottlerin ( PKCd inhibitor ) inhibited PMA induced [MUC16] expression , and also *inhibited* the phosphorylation of activated p38 by PMA . Negative_regulation MUC16 MAPK13 22977714 2674023 Rottlerin ( PKCd inhibitor ) inhibited PMA induced [MUC16] expression , and also *inhibited* the phosphorylation of activated p38 by PMA . Negative_regulation MUC16 MAPK14 22977714 2674024 Rottlerin ( PKCd inhibitor ) inhibited PMA induced [MUC16] expression , and also *inhibited* the phosphorylation of activated p38 by PMA . Negative_regulation MUC16 MAPK15 22977714 2674018 Rottlerin ( PKCd inhibitor ) inhibited PMA induced [MUC16] expression , and also *inhibited* the phosphorylation of activated p38 by PMA . Negative_regulation MUC16 MAPK3 22977714 2674025 Rottlerin ( PKCd inhibitor ) inhibited PMA induced [MUC16] expression , and also *inhibited* the phosphorylation of activated p38 by PMA . Negative_regulation MUC16 MAPK4 22977714 2674026 Rottlerin ( PKCd inhibitor ) inhibited PMA induced [MUC16] expression , and also *inhibited* the phosphorylation of activated p38 by PMA . Negative_regulation MUC16 MAPK6 22977714 2674027 Rottlerin ( PKCd inhibitor ) inhibited PMA induced [MUC16] expression , and also *inhibited* the phosphorylation of activated p38 by PMA . Negative_regulation MUC16 MAPK7 22977714 2674028 Rottlerin ( PKCd inhibitor ) inhibited PMA induced [MUC16] expression , and also *inhibited* the phosphorylation of activated p38 by PMA . Negative_regulation MUC16 MAPK8 22977714 2674029 Rottlerin ( PKCd inhibitor ) inhibited PMA induced [MUC16] expression , and also *inhibited* the phosphorylation of activated p38 by PMA . Negative_regulation MUC16 MAPK9 22977714 2674030 Rottlerin ( PKCd inhibitor ) inhibited PMA induced [MUC16] expression , and also *inhibited* the phosphorylation of activated p38 by PMA . Negative_regulation MUC16 MB 8741012 374302 However , in the *presence* of the nitric oxide scavenger , [mucin] secretion and cell damage were abrogated . Negative_regulation MUC16 MDM1 24556631 2924505 The present study demonstrates that AZM and *suppress* the synthesis of [mucin] and TNF-a from human airway epithelial cells . Negative_regulation MUC16 MDM2 24556631 2924506 The present study demonstrates that AZM and *suppress* the synthesis of [mucin] and TNF-a from human airway epithelial cells . Negative_regulation MUC16 MDM4 24556631 2924507 The present study demonstrates that AZM and *suppress* the synthesis of [mucin] and TNF-a from human airway epithelial cells . Negative_regulation MUC16 MMP9 19389382 2089283 *Role* of in lipopolysaccharide induced [mucin] production in human airway epithelial cells . Negative_regulation MUC16 MSI1 15696080 1371999 Niflumic acid and *reduce* TNF-alpha induced [mucin] expression in human airway mucosa . Negative_regulation MUC16 MSI2 15696080 1371998 Niflumic acid and *reduce* TNF-alpha induced [mucin] expression in human airway mucosa . Negative_regulation MUC16 MTRNR2L1 20635390 2395209 In addition , can functionally *block* the interaction of mesothelin and [CA125] on cancer cells . Negative_regulation MUC16 MUC3A 12740338 1088132 To determine whether increased epithelial cell mucin expression in response to Lactobacillus strains *results* in increased extracellular secretion of MUC3 mucins and the importance of epithelial cell adherence in modulation of MUC3 [mucin] expression . Negative_regulation MUC16 NA 23118923 2696044 *inhibits* RSV infection and [mucin] release in human A549 cells . Negative_regulation MUC16 PAK2 17555715 1753007 Opposing *roles* of and PAK4 in synergistic induction of MUC5AC [mucin] by bacterium NTHi and EGF . Negative_regulation MUC16 PAK4 17555715 1753006 Opposing *roles* of PAK2 and in synergistic induction of MUC5AC [mucin] by bacterium NTHi and EGF . Negative_regulation MUC16 PLA2G1B 16249480 1471745 Effect of retinoic acid on gene expression in human conjunctival epithelium : secretory *mediates* retinoic acid induction of [MUC16] . Negative_regulation MUC16 PLA2G4A 16983494 1617426 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* ERK dependent activation that leads to up-regulation in PAF production and ET-1 generation . Negative_regulation MUC16 PPARG 16443643 1567240 However , no data are available on the *role* of in smoke induced [mucin] production . Negative_regulation MUC16 PTPN6 20117097 2213182 In this study , we investigated the *role* of in [mucin] secretion triggered by oxidative stress . Negative_regulation MUC16 RNPEP 16139976 1475291 UTP induced [mucin] secretion was also *suppressed* by U73122 and <2-APB> , while Calphostin C suppressed it to a small extent and PD98059 was ineffective . Negative_regulation MUC16 SCIN 15342343 1353769 ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* [mucin] secretion . Negative_regulation MUC16 SPHK1 19835973 2203043 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Negative_regulation MUC16 SPHK2 19835973 2203044 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Negative_regulation MUC16 SPINK1 16340249 1504014 It was the aim of this study to evaluate the prognostic value of the pretreatment serum concentrations of the beta-subunit of human chorionic gonadotropin ( hCGbeta ) , [CA 125] and tumour associated trypsin *inhibitor* ( ) in primary fallopian tube carcinoma ( PFTC ) . Negative_regulation MUC16 SPINK1 3117086 79216 The levels of tumour associated trypsin *inhibitor* ( ) , [CA 125] and CEA were measured in ovarian cyst fluids from 21 patients . Negative_regulation MUC16 TAT 14530363 1149330 Histological examination demonstrated that inflammatory cell infiltration ( largely eosinophils and mononuclear cells ) and [mucin] production around the airways caused by OVA were *blocked* by . Negative_regulation MUC16 TFAP2A 17621592 1815995 *represses* both the [mucin] MUC4 expression and pancreatic cancer cell proliferation . Negative_regulation MUC16 TFP1 3019145 63072 The CaM antagonist *inhibited* [mucin] secretion in response to both isoproterenol and dibutyryladenosine 3',5'-cyclic monophosphate . Negative_regulation MUC16 TGFB1 15466377 1305502 We evaluated bronchial epithelial TGF-beta1 and TGF-beta2 expression and their effects on mucin expression , and the *role* of or TGF-beta2 in interleukin (IL)-13 induced [mucin] expression . Negative_regulation MUC16 TGFB2 15466377 1305503 We evaluated bronchial epithelial TGF-beta1 and TGF-beta2 expression and their effects on mucin expression , and the *role* of TGF-beta1 or in interleukin (IL)-13 induced [mucin] expression . Negative_regulation MUC17 EPHB2 16983494 1617427 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Negative_regulation MUC17 EPHB2 17146999 1497019 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC17 IL1B 12869928 1112228 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Negative_regulation MUC17 MAP2K6 17146999 1497025 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC17 SCIN 15342343 1353770 ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* [mucin] secretion . Negative_regulation MUC17 SPHK1 19835973 2203045 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Negative_regulation MUC19 EPHB2 16983494 1617421 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Negative_regulation MUC19 EPHB2 17146999 1496992 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC19 IL1B 12869928 1112225 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Negative_regulation MUC19 MAP2K6 17146999 1496998 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC19 SCIN 15342343 1353767 ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* [mucin] secretion . Negative_regulation MUC19 SPHK1 19835973 2203039 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Negative_regulation MUC2 EPHB2 16983494 1617441 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Negative_regulation MUC2 EPHB2 17146999 1497098 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC2 IL1B 12482999 1024583 In cultured human airway NCI-H292 epithelial cells , the steady state of the mRNA level of [MUC2] gene expression and mucin secretion *induced* by were determined by reverse transcriptase-polymerase chain reaction ( RT-PCR ) , enzyme immunoassay , and immunoblot analysis . Negative_regulation MUC2 IL1B 12869928 1112235 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Negative_regulation MUC2 IL1B 20873538 2326417 In passage-2 cultured human nasal epithelial cells , the mRNA levels of [MUC2/MUC5B] gene expression *induced* by were determined by fluorescent quantitative RT-PCR . Negative_regulation MUC2 MAP2K6 17146999 1497104 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC2 MAP2K6 18176092 1883415 LTD ( 4 ) -induced [MUC2] gene transcriptional activity was also *suppressed* by a G-protein inhibitor ( pertussis toxin ) , a protein kinase C ( PKC ) inhibitor ( bisindolylmaleimide ) , a mitogen activated protein/extracellular signal regulated kinase kinase ( ) inhibitor ( PD98059 ) , an extracellular signal regulated kinase-2 ( ERK-2 ) inhibitor ( AG126 ) and a nuclear factor kappaB (NF-kappaB) inhibitor . Negative_regulation MUC2 SCIN 15342343 1353792 ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* [mucin] secretion . Negative_regulation MUC2 SPHK1 19835973 2203059 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Negative_regulation MUC20 EPHB2 16983494 1617431 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Negative_regulation MUC20 EPHB2 17146999 1497037 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC20 IL1B 12869928 1112230 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Negative_regulation MUC20 MAP2K6 17146999 1497043 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC20 SCIN 15342343 1353787 ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* [mucin] secretion . Negative_regulation MUC20 SPHK1 19835973 2203049 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Negative_regulation MUC21 EPHB2 16983494 1617429 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Negative_regulation MUC21 EPHB2 17146999 1497028 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC21 IL1B 12869928 1112229 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Negative_regulation MUC21 MAP2K6 17146999 1497034 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC21 SCIN 15342343 1353771 ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* [mucin] secretion . Negative_regulation MUC21 SPHK1 19835973 2203047 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Negative_regulation MUC22 EPHB2 16983494 1617433 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Negative_regulation MUC22 EPHB2 17146999 1497055 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC22 IL1B 12869928 1112231 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Negative_regulation MUC22 MAP2K6 17146999 1497061 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC22 SCIN 15342343 1353788 ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* [mucin] secretion . Negative_regulation MUC22 SPHK1 19835973 2203051 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Negative_regulation MUC3A MUC16 12740338 1088143 To determine whether increased epithelial cell MUC3 expression in response to Lactobacillus strains *results* in increased extracellular secretion of MUC3 mucins and the importance of epithelial cell adherence in modulation of [MUC3] mucin expression . Negative_regulation MUC4 EPHB2 16983494 1617443 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Negative_regulation MUC4 EPHB2 17146999 1497107 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC4 IL1B 12869928 1112236 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Negative_regulation MUC4 MAP2K6 17146999 1497113 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC4 SCIN 15342343 1353793 ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* [mucin] secretion . Negative_regulation MUC4 SPHK1 19835973 2203061 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Negative_regulation MUC5AC EPHB2 19109160 2018904 This synergistic effect on [MUC5AC] production may be *due* to enhanced activation of through inhibition of MKP3 by poly ( I : Negative_regulation MUC5AC EPHB2 21622856 2446081 These results suggested that activation is *necessary* for the regulation of EGF receptor (EGFR) mediated [MUC5AC] expression by Notch signaling . Negative_regulation MUC5AC IL1B 15266025 1275899 We found that increased cyclooxygenase-2 (COX-2) mRNA expression and prostaglandin ( PG ) E ( 2 ) production and that the COX-2 inhibitor celecoxib *suppressed* IL-1beta induced [MUC5AC] production . Negative_regulation MUC5B IL1B 20873538 2326418 In passage-2 cultured human nasal epithelial cells , the mRNA levels of [MUC2/MUC5B] gene expression *induced* by were determined by fluorescent quantitative RT-PCR . Negative_regulation MUC6 EPHB2 16983494 1617445 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Negative_regulation MUC6 EPHB2 17146999 1497116 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC6 IL1B 12869928 1112237 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Negative_regulation MUC6 MAP2K6 17146999 1497122 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC6 SCIN 15342343 1353794 ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* [mucin] secretion . Negative_regulation MUC6 SPHK1 19835973 2203063 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Negative_regulation MUC7 EPHB2 16983494 1617447 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Negative_regulation MUC7 EPHB2 17146999 1497125 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC7 IL1B 12869928 1112238 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Negative_regulation MUC7 MAP2K6 17146999 1497131 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC7 SCIN 15342343 1353795 ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* [mucin] secretion . Negative_regulation MUC7 SPHK1 19835973 2203065 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Negative_regulation MUC8 EPHB2 16983494 1617449 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Negative_regulation MUC8 EPHB2 17146999 1497134 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC8 IL1B 12869928 1112239 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Negative_regulation MUC8 MAP2K6 17146999 1497140 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. , BK ( Ca ) channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. , benzafibrate ) , inhibitors of mucin exocytosis ( e.g. , anti-MARCKS peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. , EGF receptor tyrosine kinase inhibitors , p38 MAP kinase inhibitors , inhibitors , hCACL2 blockers and retinoic acid receptor-alpha antagonists ) , inducers of goblet cell apoptosis ( e.g. , Bax inducers or Bcl-2 inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Negative_regulation MUC8 SCIN 15342343 1353796 ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* [mucin] secretion . Negative_regulation MUC8 SPHK1 19835973 2203067 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Negative_regulation MVD ANO1 11501049 766104 significantly *inhibited* the [MVD] in Lewis lung carcinoma model and this effect was correlated with its inhibition of the tumor growth . Negative_regulation MXD1 TNF 22025632 2508085 This abbreviated mitotic phase is correlated with a *induced* reduction in the kinetochore localization of [MAD2] during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation MYB CCND1 15687240 1395452 Assays using model reporter constructs as well as endogenous target genes showed that the activity of [c-Myb] was *inhibited* by plus CDK4 or CDK6 but stimulated by expression of the CDK inhibitors p16 Ink4a , p21 Cip1 , or p27 Kip1 . Negative_regulation MYBL2 CCND1 14973551 1212433 Based on our results we propose that *inhibits* the activity of [B-Myb] by interfering with the interaction of B-Myb and p300 . Negative_regulation MYC AXIN2 24299953 2894652 Nuclear *represses* [MYC] gene expression . Negative_regulation MYC AXIN2 24299953 2894664 When constitutively localized to the nucleus , alters the chromatin structure at the MYC promoter and directly *represses* [MYC] gene expression . Negative_regulation MYC CCND1 19698176 2133266 Immunoblot analysis showed that expression of [c-Myc] protein was significantly downregulated by ApoG2 and that the expression of c-Myc 's downstream molecules and cyclin E were *inhibited* whereas p21 was induced . Negative_regulation MYC EPHB2 15811177 1397490 Therefore , our main aim was to examine the levels of MAPK in Myc transformed cells in light of the *roles* of in cell cycle and control of [Myc] protein levels . Negative_regulation MYC EPHB2 16596619 1550259 We found that phosphorylation caused by Cpd 5 induced c-Myc phosphorylation , but *suppressed* [c-Myc] expression at the mRNA and protein levels . Negative_regulation MYC FOXO1 16959612 1611245 We found the transcription factor C/EBPbeta to be essential for TGFbeta induction of the cell cycle inhibitor p15INK4b by a complex and *repression* of [c-MYC] by an E2F4/5-Smad complex in human epithelial cells . Negative_regulation MYC TNF 3099296 69078 *inhibits* [MYC] expression in HL-60 cells at the level of mRNA transcription . Negative_regulation MYD88 EPHB2 22743248 2644399 Our flow cytometry and Western blot data showed that paclitaxel activated [TLR4-MyD88-ERK] signaling and that IS treatment could effectively *inhibit* this paclitaxel induced activation of signaling . Negative_regulation MYD88 IL1B 11976320 953992 CaMKKc and Akt overexpression decreases IRAK1 mediated NF-kappaB activity and its association with [MyD88] in *response* to stimulation . Negative_regulation MYD88 MAP2K6 19737531 2152781 CpG ODN induced expression of tissue factor ( TF ) and NGFI-A binding protein 2 (Nab2) , and the expression of both genes is blocked by knockdown of TLR9 or [MyD88] siRNA or *inhibition* . Negative_regulation MYF5 CTGF 20580899 2296204 Furthermore , HGF *enhanced* the gene expression of muscle regulatory factors MyoD and [Myf5] , while suppressing expression of fibrosis related genes , and alpha-smooth muscle actin . Negative_regulation MYF6 FOXO1 12561432 1053762 does not *inhibit* the expression of [MRF4] , but can reverse the effect of MRF4 on promoting the differentiation of RD cell . Negative_regulation MYH1 MAP2K6 12016267 942230 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH1 S100B 9395540 468750 The induction of [beta-myosin heavy chain] by hypoxia was similarly *blocked* by forced expression of . Negative_regulation MYH10 MAP2K6 12016267 942238 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH10 S100B 9395540 468751 The induction of [beta-myosin heavy chain] by hypoxia was similarly *blocked* by forced expression of . Negative_regulation MYH11 MAP2K6 12016267 942246 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH11 S100B 9395540 468752 The induction of [beta-myosin heavy chain] by hypoxia was similarly *blocked* by forced expression of . Negative_regulation MYH13 MAP2K6 12016267 942254 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH13 S100B 9395540 468753 The induction of [beta-myosin heavy chain] by hypoxia was similarly *blocked* by forced expression of . Negative_regulation MYH14 MAP2K6 12016267 942206 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH14 S100B 9395540 468747 The induction of [beta-myosin heavy chain] by hypoxia was similarly *blocked* by forced expression of . Negative_regulation MYH15 MAP2K6 12016267 942222 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH15 S100B 9395540 468749 The induction of [beta-myosin heavy chain] by hypoxia was similarly *blocked* by forced expression of . Negative_regulation MYH16 ATP5O 15498825 1367001 Rats were given propylthiouracil ( PTU ) for 8 days to *induce* a 25 % increase in [beta-myosin heavy chain] with a 28 % reduction in actomyosin activity . Negative_regulation MYH16 BHLHE41 15448136 1341922 Although MyoD expression is not inhibited , the induction of differentiation-specific genes such as myogenin , MEF2C , and [myosin heavy chain] is *impaired* by overexpression . Negative_regulation MYH16 CDC42 10930450 719846 We report here that dominant negative forms of Rac1 and *inhibit* the expression of the muscle-specific genes myogenin , troponin T , and [myosin heavy chain] in L6 and C2 myoblasts . Negative_regulation MYH16 CDK2 15466361 1305453 Cyclic strain increased the activity of and the cellular level of cyclin A , and *inhibited* the expression of [myosin heavy chain] and formation of myotubes in C2C12 cultures . Negative_regulation MYH16 CDKN2A 11108967 757067 In the present study , we have shown that interaction of with the human platelet myosin or C-terminal fragment of the myosin heavy chain *inhibits* phosphorylation of the [myosin heavy chain] by protein kinase CK2 in vitro . Negative_regulation MYH16 EGF 8912716 395449 In enriched cell lines and in a pure myocyte cell strain , *inhibited* increases in immunoreactive sarcomeric actin and sarcomeric [myosin heavy chain] ( SMHC ) normally seen after serum withdrawal . Negative_regulation MYH16 FBLN1 11792823 892153 However , was found to inhibit extracellular signal regulated kinase ( ERK ) activation and to *suppress* phosphorylation of [myosin heavy chain] . Negative_regulation MYH16 FGF2 9590508 504829 Compared to cells cultured in serum alone , smooth muscle alpha-actin and [myosin heavy chain] expression was markedly *reduced* by added , but was not influenced by antisense inhibition of bFGF expression . Negative_regulation MYH16 GATA6 15550397 1367798 In contrast , and myocardin *resulted* in synergistic activation of the smooth muscle [myosin heavy chain] promoter . Negative_regulation MYH16 HAND1 10837146 699310 also *inhibits* MyoD dependent skeletal muscle cell differentiation and expression of the muscle-specific [myosin heavy chain] protein . Negative_regulation MYH16 IL15 12372339 996325 Overexpression of *induced* fivefold higher levels of sarcomeric [myosin heavy chain] and alpha-actin accumulation in differentiated myotubes . Negative_regulation MYH16 ILK 18805960 1993435 The depletion of protein *increased* the expression of the smooth muscle differentiation marker genes [myosin heavy chain] ( SmMHC ) , SM22alpha , and calponin and increased the expression of SmMHC protein . Negative_regulation MYH16 JUN 17720185 1801558 Overt expression of *reduces* alpha [myosin heavy chain] expression and contributes to heart failure from chronic volume overload . Negative_regulation MYH16 MAP2K1 12016267 942209 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH16 MAP2K2 12016267 942210 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH16 MAP2K3 12016267 942211 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH16 MAP2K4 12016267 942212 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH16 MAP2K5 12016267 942213 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH16 MAP2K6 12016267 942214 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH16 MAP2K7 12016267 942215 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH16 MEF2A 12016267 942216 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of or mitogen activated protein kinase kinase 6 . Negative_regulation MYH16 MKL1 16997888 1692493 Importantly , a dominant negative form of ( DeltaB1/B2 ) that traps endogenous MRTFs in the cytoplasm *inhibited* the SM alpha-actin , SM22alpha , and SM [myosin heavy chain] promoters in SMC and attenuated the effects of sphingosine 1-phosphate and transforming growth factor (TGF)-beta on SMC-specific transcription . Negative_regulation MYH16 MMP9 10937947 580680 Altered balance between matrix gelatinases ( MMP-2 and MMP-9 ) and their tissue inhibitors in human dilated cardiomyopathy : potential *role* of in [myosin-heavy chain] degradation . Negative_regulation MYH16 MSH2 20223032 1506464 We reasoned that because of the clinical similarity of a subset of HNPCC patients to those described with MYH mutations and the *role* of the complex in the activation of [MYH] protein that MYH mutations may account for a small proportion of HNPCC patients . Negative_regulation MYH16 MSH6 20223032 1506465 We reasoned that because of the clinical similarity of a subset of HNPCC patients to those described with MYH mutations and the *role* of the complex in the activation of [MYH] protein that MYH mutations may account for a small proportion of HNPCC patients . Negative_regulation MYH16 MSTN 22910409 2672212 facilitates slow and *inhibits* fast [myosin heavy chain] expression during myogenic differentiation . Negative_regulation MYH16 MSTN 22910409 2672226 Interestingly , Mstn knockout led to a shift of Myh towards faster isoforms , suggesting an inhibitory *role* of in fast [Myh] expression . Negative_regulation MYH16 MYEF2 8449897 214044 *Role* of myocyte-specific enhancer binding factor ( ) in transcriptional regulation of the alpha-cardiac [myosin heavy chain] gene . Negative_regulation MYH16 MYH7 15247427 1274154 VIVIT was found to block the expression of slow [myosin heavy chain] ( MyHC-slow ) induced by slow motor neuron activity in regenerating slow soleus muscle and to *inhibit* the expression of transcripts and the activity of a MyHC-slow promoter in adult soleus . Negative_regulation MYH16 MYLIP 20458739 2307529 Over-expression of in cardiomyocytes increased the cell size as measured by cell surface area , and also *reduced* the mRNA expression level of [alpha-myosin heavy chain] . Negative_regulation MYH16 MYLIP 24014830 2856852 Furthermore , we demonstrated that overexpression of *increased* expression of VSMC differentiation marker genes , such as smooth muscle 22a , smooth muscle a-actin , calponin , and smooth muscle [myosin heavy chain] , and potently inhibited platelet derived growth factor induced VSMC proliferation and migration . Negative_regulation MYH16 MYOCD 15550397 1367797 In contrast , GATA-6 and *resulted* in synergistic activation of the smooth muscle [myosin heavy chain] promoter . Negative_regulation MYH16 MYOCD 22937150 2666941 overexpression from day 10 to day 28 of embryoid body differentiation *increased* the number of smooth muscle a-actin ( + ) and smooth muscle [myosin heavy chain] ( + ) SMC-like cells and increased carbachol induced contractile function . Negative_regulation MYH16 MYOG 20561744 2315824 We demonstrate that small interference RNA mediated knockdown of AGPAT1 expression prevents the induction of , a key transcriptional activator of the myogenic program , and *inhibits* the expression of [myosin heavy chain] . Negative_regulation MYH16 PIAS1 16135793 1450407 Overexpression of significantly *activated* the SM alpha-actin promoter and mRNA expression , as well as SM [myosin heavy chain] and SM22alpha , whereas a small interfering RNA for PIAS1 decreased activity of these promoters , as well as endogenous mRNA expression , and SRF binding to SM alpha-actin promoter within intact chromatin in cultured SMC . Negative_regulation MYH16 PRKCA 16155104 1499474 overexpression in cardiomyocytes *caused* marked repression of triiodothyronine ( T3 ) -responsive genes , [alpha-myosin heavy chain] , and the sarcoplasmic reticulum calcium activated adenosinetriphosphatase SERCA2 . Negative_regulation MYH16 RAC1 10930450 719847 We report here that dominant negative forms of and Cdc42Hs *inhibit* the expression of the muscle-specific genes myogenin , troponin T , and [myosin heavy chain] in L6 and C2 myoblasts . Negative_regulation MYH16 RETN 18597775 1947092 Adenovirus mediated overexpression of in cultured neonatal rat ventricular myocytes ( NRVM ) significantly increased sarcomere organization and cell size , increased protein synthesis and *increased* the expression of atrial natriuretic factor and [beta-myosin heavy chain] . Negative_regulation MYH16 S100B 9395540 468748 The induction of [beta-myosin heavy chain] by hypoxia was similarly *blocked* by forced expression of . Negative_regulation MYH16 SERPINB5 12927046 1131600 SMA negative ME cells in two cases also failed to display immunoreactivity for other markers , including calponin , CD10 , smooth muscle [myosin heavy chain] , protease *inhibitor* 5 ( ) , Wilms' tumor-1 , and cytokeratins 5 , 14 , and 17 ( CK5 , CK14 , and CK17 ) . Negative_regulation MYH16 SIL1 24431215 2922405 Both and BPDE *inhibited* the muscle-specific protein expressions ( myogenin and [myosin heavy chain] ) and phosphorylation of Akt ( a known modulator in myogenesis ) , which could be significantly reversed by the inhibitors for aryl hydrocarbon receptor (AhR) , estrogen receptor (ER) , and nuclear factor ( NF ) -?B . Negative_regulation MYH16 SMAD6 11712667 880259 TGF-beta increased the expression of alpha-smooth muscle actin and [myosin heavy chain] by 1.3-fold and 1.6-fold in comparison to the control , respectively , and these increases were *attenuated* by exogenous Smad7 , but not . Negative_regulation MYH16 SMAD7 11712667 880260 TGF-beta increased the expression of alpha-smooth muscle actin and [myosin heavy chain] by 1.3-fold and 1.6-fold in comparison to the control , respectively , and these increases were *attenuated* by exogenous , but not Smad6 . Negative_regulation MYH16 SRF 15950986 1440603 However , overexpression of exogenous in isolated cardiomyocytes is only *sufficient* to induce NCX1 and [alpha-myosin heavy chain] . Negative_regulation MYH16 SRF 20685657 2329493 As a result , decreased expression *reduces* expression of SRF target genes such as smooth muscle a-actin and smooth muscle [myosin heavy chain] . Negative_regulation MYH16 TDG 18945672 2000940 Conversely , depletion of endogenous in SMCs *increased* smooth muscle-specific [myosin heavy chain] ( SM MHC ) and Telokin gene expression . Negative_regulation MYH16 VGLL2 12376544 1019889 Overexpression of in MyoD transfected 10T(1/2) cells markedly *increased* [myosin heavy chain] expression , a marker of terminal muscle differentiation . Negative_regulation MYH16 YY1 15567155 1355441 *represses* [alpha-myosin heavy chain] gene expression in pathologic cardiac hypertrophy . Negative_regulation MYH2 MAP2K6 12016267 942262 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH2 S100B 9395540 468754 The induction of [beta-myosin heavy chain] by hypoxia was similarly *blocked* by forced expression of . Negative_regulation MYH3 ATP5O 15498825 1367008 Rats were given propylthiouracil ( PTU ) for 8 days to *induce* a 25 % increase in [beta-myosin heavy chain] with a 28 % reduction in actomyosin activity . Negative_regulation MYH3 BHLHE41 15448136 1341930 Although MyoD expression is not inhibited , the induction of differentiation-specific genes such as myogenin , MEF2C , and [myosin heavy chain] is *impaired* by overexpression . Negative_regulation MYH3 CDC42 10930450 719860 We report here that dominant negative forms of Rac1 and *inhibit* the expression of the muscle-specific genes myogenin , troponin T , and [myosin heavy chain] in L6 and C2 myoblasts . Negative_regulation MYH3 CDK2 15466361 1305460 Cyclic strain increased the activity of and the cellular level of cyclin A , and *inhibited* the expression of [myosin heavy chain] and formation of myotubes in C2C12 cultures . Negative_regulation MYH3 CDKN2A 11108967 757074 In the present study , we have shown that interaction of with the human platelet myosin or C-terminal fragment of the myosin heavy chain *inhibits* phosphorylation of the [myosin heavy chain] by protein kinase CK2 in vitro . Negative_regulation MYH3 EGF 8912716 395456 In enriched cell lines and in a pure myocyte cell strain , *inhibited* increases in immunoreactive sarcomeric actin and sarcomeric [myosin heavy chain] ( SMHC ) normally seen after serum withdrawal . Negative_regulation MYH3 FBLN1 11792823 892160 However , was found to inhibit extracellular signal regulated kinase ( ERK ) activation and to *suppress* phosphorylation of [myosin heavy chain] . Negative_regulation MYH3 FGF2 9590508 504836 Compared to cells cultured in serum alone , smooth muscle alpha-actin and [myosin heavy chain] expression was markedly *reduced* by added , but was not influenced by antisense inhibition of bFGF expression . Negative_regulation MYH3 GATA6 15550397 1367812 In contrast , and myocardin *resulted* in synergistic activation of the smooth muscle [myosin heavy chain] promoter . Negative_regulation MYH3 HAND1 10837146 699317 also *inhibits* MyoD dependent skeletal muscle cell differentiation and expression of the muscle-specific [myosin heavy chain] protein . Negative_regulation MYH3 IL15 12372339 996346 Overexpression of *induced* fivefold higher levels of sarcomeric [myosin heavy chain] and alpha-actin accumulation in differentiated myotubes . Negative_regulation MYH3 ILK 18805960 1993442 The depletion of protein *increased* the expression of the smooth muscle differentiation marker genes [myosin heavy chain] ( SmMHC ) , SM22alpha , and calponin and increased the expression of SmMHC protein . Negative_regulation MYH3 JUN 17720185 1801565 Overt expression of *reduces* alpha [myosin heavy chain] expression and contributes to heart failure from chronic volume overload . Negative_regulation MYH3 MAP2K1 12016267 942265 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH3 MAP2K2 12016267 942266 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH3 MAP2K3 12016267 942267 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH3 MAP2K4 12016267 942268 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH3 MAP2K5 12016267 942269 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH3 MAP2K6 12016267 942270 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH3 MAP2K7 12016267 942271 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH3 MEF2A 12016267 942272 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of or mitogen activated protein kinase kinase 6 . Negative_regulation MYH3 MKL1 16997888 1692500 Importantly , a dominant negative form of ( DeltaB1/B2 ) that traps endogenous MRTFs in the cytoplasm *inhibited* the SM alpha-actin , SM22alpha , and SM [myosin heavy chain] promoters in SMC and attenuated the effects of sphingosine 1-phosphate and transforming growth factor (TGF)-beta on SMC-specific transcription . Negative_regulation MYH3 MMP9 10937947 580687 Altered balance between matrix gelatinases ( MMP-2 and MMP-9 ) and their tissue inhibitors in human dilated cardiomyopathy : potential *role* of in [myosin-heavy chain] degradation . Negative_regulation MYH3 MSH2 20223032 1506478 We reasoned that because of the clinical similarity of a subset of HNPCC patients to those described with MYH mutations and the *role* of the complex in the activation of [MYH] protein that MYH mutations may account for a small proportion of HNPCC patients . Negative_regulation MYH3 MSH6 20223032 1506479 We reasoned that because of the clinical similarity of a subset of HNPCC patients to those described with MYH mutations and the *role* of the complex in the activation of [MYH] protein that MYH mutations may account for a small proportion of HNPCC patients . Negative_regulation MYH3 MSTN 22910409 2672219 facilitates slow and *inhibits* fast [myosin heavy chain] expression during myogenic differentiation . Negative_regulation MYH3 MSTN 22910409 2672233 Interestingly , Mstn knockout led to a shift of Myh towards faster isoforms , suggesting an inhibitory *role* of in fast [Myh] expression . Negative_regulation MYH3 MYEF2 8449897 214051 *Role* of myocyte-specific enhancer binding factor ( ) in transcriptional regulation of the alpha-cardiac [myosin heavy chain] gene . Negative_regulation MYH3 MYH7 15247427 1274161 VIVIT was found to block the expression of slow [myosin heavy chain] ( MyHC-slow ) induced by slow motor neuron activity in regenerating slow soleus muscle and to *inhibit* the expression of transcripts and the activity of a MyHC-slow promoter in adult soleus . Negative_regulation MYH3 MYLIP 20458739 2307536 Over-expression of in cardiomyocytes increased the cell size as measured by cell surface area , and also *reduced* the mRNA expression level of [alpha-myosin heavy chain] . Negative_regulation MYH3 MYLIP 24014830 2856859 Furthermore , we demonstrated that overexpression of *increased* expression of VSMC differentiation marker genes , such as smooth muscle 22a , smooth muscle a-actin , calponin , and smooth muscle [myosin heavy chain] , and potently inhibited platelet derived growth factor induced VSMC proliferation and migration . Negative_regulation MYH3 MYOCD 15550397 1367811 In contrast , GATA-6 and *resulted* in synergistic activation of the smooth muscle [myosin heavy chain] promoter . Negative_regulation MYH3 MYOCD 22937150 2666948 overexpression from day 10 to day 28 of embryoid body differentiation *increased* the number of smooth muscle a-actin ( + ) and smooth muscle [myosin heavy chain] ( + ) SMC-like cells and increased carbachol induced contractile function . Negative_regulation MYH3 MYOG 20561744 2315831 We demonstrate that small interference RNA mediated knockdown of AGPAT1 expression prevents the induction of , a key transcriptional activator of the myogenic program , and *inhibits* the expression of [myosin heavy chain] . Negative_regulation MYH3 PIAS1 16135793 1450414 Overexpression of significantly *activated* the SM alpha-actin promoter and mRNA expression , as well as SM [myosin heavy chain] and SM22alpha , whereas a small interfering RNA for PIAS1 decreased activity of these promoters , as well as endogenous mRNA expression , and SRF binding to SM alpha-actin promoter within intact chromatin in cultured SMC . Negative_regulation MYH3 PRKCA 16155104 1499481 overexpression in cardiomyocytes *caused* marked repression of triiodothyronine ( T3 ) -responsive genes , [alpha-myosin heavy chain] , and the sarcoplasmic reticulum calcium activated adenosinetriphosphatase SERCA2 . Negative_regulation MYH3 RAC1 10930450 719861 We report here that dominant negative forms of and Cdc42Hs *inhibit* the expression of the muscle-specific genes myogenin , troponin T , and [myosin heavy chain] in L6 and C2 myoblasts . Negative_regulation MYH3 RETN 18597775 1947099 Adenovirus mediated overexpression of in cultured neonatal rat ventricular myocytes ( NRVM ) significantly increased sarcomere organization and cell size , increased protein synthesis and *increased* the expression of atrial natriuretic factor and [beta-myosin heavy chain] . Negative_regulation MYH3 S100B 9395540 468755 The induction of [beta-myosin heavy chain] by hypoxia was similarly *blocked* by forced expression of . Negative_regulation MYH3 SERPINB5 12927046 1131607 SMA negative ME cells in two cases also failed to display immunoreactivity for other markers , including calponin , CD10 , smooth muscle [myosin heavy chain] , protease *inhibitor* 5 ( ) , Wilms' tumor-1 , and cytokeratins 5 , 14 , and 17 ( CK5 , CK14 , and CK17 ) . Negative_regulation MYH3 SIL1 24431215 2922415 Both and BPDE *inhibited* the muscle-specific protein expressions ( myogenin and [myosin heavy chain] ) and phosphorylation of Akt ( a known modulator in myogenesis ) , which could be significantly reversed by the inhibitors for aryl hydrocarbon receptor (AhR) , estrogen receptor (ER) , and nuclear factor ( NF ) -?B . Negative_regulation MYH3 SMAD6 11712667 880273 TGF-beta increased the expression of alpha-smooth muscle actin and [myosin heavy chain] by 1.3-fold and 1.6-fold in comparison to the control , respectively , and these increases were *attenuated* by exogenous Smad7 , but not . Negative_regulation MYH3 SMAD7 11712667 880274 TGF-beta increased the expression of alpha-smooth muscle actin and [myosin heavy chain] by 1.3-fold and 1.6-fold in comparison to the control , respectively , and these increases were *attenuated* by exogenous , but not Smad6 . Negative_regulation MYH3 SRF 15950986 1440610 However , overexpression of exogenous in isolated cardiomyocytes is only *sufficient* to induce NCX1 and [alpha-myosin heavy chain] . Negative_regulation MYH3 SRF 20685657 2329500 As a result , decreased expression *reduces* expression of SRF target genes such as smooth muscle a-actin and smooth muscle [myosin heavy chain] . Negative_regulation MYH3 TDG 18945672 2000947 Conversely , depletion of endogenous in SMCs *increased* smooth muscle-specific [myosin heavy chain] ( SM MHC ) and Telokin gene expression . Negative_regulation MYH3 VGLL2 12376544 1019896 Overexpression of in MyoD transfected 10T(1/2) cells markedly *increased* [myosin heavy chain] expression , a marker of terminal muscle differentiation . Negative_regulation MYH3 YY1 15567155 1355448 *represses* [alpha-myosin heavy chain] gene expression in pathologic cardiac hypertrophy . Negative_regulation MYH4 MAP2K6 12016267 942278 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH4 S100B 9395540 468756 The induction of [beta-myosin heavy chain] by hypoxia was similarly *blocked* by forced expression of . Negative_regulation MYH6 MAP2K6 12016267 942286 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH6 S100B 9395540 468757 The induction of [beta-myosin heavy chain] by hypoxia was similarly *blocked* by forced expression of . Negative_regulation MYH7 MAP2K6 12016267 942294 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH7 MYH16 15247427 1274165 VIVIT was found to block the expression of slow ( MyHC-slow ) induced by slow motor neuron activity in regenerating slow soleus muscle and to *inhibit* the expression of [MyHC-slow] transcripts and the activity of a MyHC-slow promoter in adult soleus . Negative_regulation MYH7 MYH3 15247427 1274172 VIVIT was found to block the expression of slow ( MyHC-slow ) induced by slow motor neuron activity in regenerating slow soleus muscle and to *inhibit* the expression of [MyHC-slow] transcripts and the activity of a MyHC-slow promoter in adult soleus . Negative_regulation MYH7 S100B 9395540 468758 The induction of [beta-myosin heavy chain] by hypoxia was similarly *blocked* by forced expression of . Negative_regulation MYH8 MAP2K6 12016267 942302 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH8 S100B 9395540 468759 The induction of [beta-myosin heavy chain] by hypoxia was similarly *blocked* by forced expression of . Negative_regulation MYH9 MAP2K6 12016267 942310 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or 6 . Negative_regulation MYH9 S100B 9395540 468760 The induction of [beta-myosin heavy chain] by hypoxia was similarly *blocked* by forced expression of . Negative_regulation MYL1 SPHK1 17164439 1716993 Overexpressing human in these cells *resulted* in increased levels of the cell cycle regulator cyclin D1 and increased [myosin light-chain] phosphorylation . Negative_regulation MYL10 SPHK1 17164439 1716992 Overexpressing human in these cells *resulted* in increased levels of the cell cycle regulator cyclin D1 and increased [myosin light-chain] phosphorylation . Negative_regulation MYL2 SPHK1 17164439 1716994 Overexpressing human in these cells *resulted* in increased levels of the cell cycle regulator cyclin D1 and increased [myosin light-chain] phosphorylation . Negative_regulation MYL3 SPHK1 17164439 1716995 Overexpressing human in these cells *resulted* in increased levels of the cell cycle regulator cyclin D1 and increased [myosin light-chain] phosphorylation . Negative_regulation MYL4 SPHK1 17164439 1716996 Overexpressing human in these cells *resulted* in increased levels of the cell cycle regulator cyclin D1 and increased [myosin light-chain] phosphorylation . Negative_regulation MYL5 SPHK1 17164439 1716997 Overexpressing human in these cells *resulted* in increased levels of the cell cycle regulator cyclin D1 and increased [myosin light-chain] phosphorylation . Negative_regulation MYL6 SPHK1 17164439 1716998 Overexpressing human in these cells *resulted* in increased levels of the cell cycle regulator cyclin D1 and increased [myosin light-chain] phosphorylation . Negative_regulation MYL7 SPHK1 17164439 1716991 Overexpressing human in these cells *resulted* in increased levels of the cell cycle regulator cyclin D1 and increased [myosin light-chain] phosphorylation . Negative_regulation MYL9 SPHK1 17164439 1716989 Overexpressing human in these cells *resulted* in increased levels of the cell cycle regulator cyclin D1 and increased [myosin light-chain] phosphorylation . Negative_regulation MYLIP AXIN2 17989227 1826813 This [miR-315] activity was *mediated* by direct inhibition of and Notum , which encode essential , negatively acting components of the Wg pathway . Negative_regulation MYLIP CTGF 23681229 2785459 Loss of as an unfavorable prognosis factor *activates* [miR-18b] by PI3K/AKT/C-Jun and C-Myc and promotes cell growth in nasopharyngeal carcinoma . Negative_regulation MYLIP CTGF 23681229 2785460 Subsequently , we discovered that the reduction of *increased* the expression of [miR-18b] , an oncomir promoting cell proliferation . Negative_regulation MYLIP EPHB2 19854889 2187509 Therefore the decrease in [miR-190] expression *resulted* from the agonist-selective phosphorylation . Negative_regulation MYLIP EPHB2 24253315 2898102 In addition , miR-29b is upregulated following ERK inhibition , suggesting a Snail dependent pathway by which Snail activation of TGF-ß and signaling *results* in downregulation of [miR-29b] and subsequent upregulation of SPARC . Negative_regulation MYLIP FAS 22431000 2809082 [miR-106a] is frequently upregulated in gastric cancer and *inhibits* the extrinsic apoptotic pathway by targeting . Negative_regulation MYLIP IL1B 20131257 2248446 Furthermore , induced activation of signal transduction pathways associated with the expression of MMP-13 *down-regulated* the expression of [miR-27b] . Negative_regulation MYLIP PTGER2 21081469 2376767 or EP4 siRNA or antagonists *impaired* the nicotine mediated NF-?B activity , upregulation of [miR-16] and miR-21 and cell proliferation . Negative_regulation MYLIP TNF 21686130 2446440 expression was similar in AD and control brains but [miR-128a/b] levels were significantly *reduced* in the temporal cortex and miR-128b in the frontal cortex in AD . Negative_regulation MYLIP TNF 22773691 2659883 *attenuated* [miR-140-3p] expression in NAASM and AASM cells , but at a greater magnitude in AASM cells . Negative_regulation MYLIP TNF 23074166 2740415 [miR-21] was *suppressed* by during the osteogenesis of MSCs . Negative_regulation MYLIP TNF 23791922 2828604 Taken together , our data indicate that HQ induces down-regulation of [miR-122] expression , leading to ADAM17 up-regulation and ADAM17 *mediated* shedding . Negative_regulation MYLK EPHB2 24116218 2853118 Collectively , our results are the first to delineate a *role* for calcium and in the activation of [MLCK] and thus MyoIIA during insulin stimulated glucose uptake in 3T3-L1 adipocytes . Negative_regulation MYLK FOXQ1 10896677 730574 strongly *represses* [telokin] promoter activity when overexpressed in A10 vascular smooth muscle cells . Negative_regulation MYLK FOXQ1 10896677 730575 *inhibits* [telokin] promoter activity , by binding to a forkhead consensus site located within an AT-rich region of the telokin promoter . Negative_regulation MYLK JAG1 24497510 2913753 In particular , directly *repressed* KIP RELATED PROTEIN 4 (KRP4) and [KRP2] , which control the transition to the DNA synthesis phase ( S-phase ) of the cell cycle . Negative_regulation MYLK MAP2K6 18511912 1939542 Inhibiting Ang II type 1 (AT1) receptor , Ras , or *blocked* the Ang II-induced increase in [smMLCK] expression . Negative_regulation MYO10 S100B 9788975 541923 We have recently reported that the Ca2+ binding protein was induced in rat heart after infarction and forced expression of S100beta in neonatal rat cardiac myocyte cultures *inhibited* alpha1-adrenergic induction of beta [myosin heavy chain (MHC)] and skeletal alpha-actin ( skACT ) . Negative_regulation MYO10 TNF 15286803 1278073 In myotubes and mouse muscles , plus IFN-gamma strongly *reduced* [myosin] expression through an RNA dependent mechanism . Negative_regulation MYO16 S100B 9788975 541922 We have recently reported that the Ca2+ binding protein was induced in rat heart after infarction and forced expression of S100beta in neonatal rat cardiac myocyte cultures *inhibited* alpha1-adrenergic induction of beta [myosin heavy chain (MHC)] and skeletal alpha-actin ( skACT ) . Negative_regulation MYO16 TNF 15286803 1278071 In myotubes and mouse muscles , plus IFN-gamma strongly *reduced* [myosin] expression through an RNA dependent mechanism . Negative_regulation MYO19 S100B 9788975 541921 We have recently reported that the Ca2+ binding protein was induced in rat heart after infarction and forced expression of S100beta in neonatal rat cardiac myocyte cultures *inhibited* alpha1-adrenergic induction of beta [myosin heavy chain (MHC)] and skeletal alpha-actin ( skACT ) . Negative_regulation MYO19 TNF 15286803 1278069 In myotubes and mouse muscles , plus IFN-gamma strongly *reduced* [myosin] expression through an RNA dependent mechanism . Negative_regulation MYO6 S100B 9788975 541924 We have recently reported that the Ca2+ binding protein was induced in rat heart after infarction and forced expression of S100beta in neonatal rat cardiac myocyte cultures *inhibited* alpha1-adrenergic induction of beta [myosin heavy chain (MHC)] and skeletal alpha-actin ( skACT ) . Negative_regulation MYO6 TNF 15286803 1278075 In myotubes and mouse muscles , plus IFN-gamma strongly *reduced* [myosin] expression through an RNA dependent mechanism . Negative_regulation MYOCD MAP2K6 18564029 1965986 Interestingly , inhibition of *induced* [myocardin] expression in BMMSC . Negative_regulation MYOD1 MSX1 1360150 204525 Here we report that forced expression of .1 blocks terminal differentiation and *results* in a corresponding decrease in steady-state levels of [MyoD1] . Negative_regulation MYOG FBXO32 19631210 2131393 overexpression *resulted* in MG132-sensitive reduction of [myogenin] . Negative_regulation MYOG FOXO1 22710712 2734517 PAX3/FOXO1A or *inhibited* [myogenin] expression and prevented terminal differentiation in murine satellite cells : the same effect as dominant negative ( DN ) Pax3 or Pax7 constructs . Negative_regulation MYOG FOXO1 22710712 2734520 The transcription of MyoD-target genes [myogenin] and muscle creatine kinase were *suppressed* by or PAX7/FOXO1A in C2C12 myogenic cells again as seen with Pax3/7DN . Negative_regulation MYOG MYH16 20561744 2315838 We demonstrate that small interference RNA mediated knockdown of AGPAT1 expression prevents the induction of [myogenin] , a key transcriptional activator of the myogenic program , and *inhibits* the expression of . Negative_regulation MYOG MYH3 20561744 2315845 We demonstrate that small interference RNA mediated knockdown of AGPAT1 expression prevents the induction of [myogenin] , a key transcriptional activator of the myogenic program , and *inhibits* the expression of . Negative_regulation MYOG S100B 20069545 2201279 Conversely , silencing expression in myoblast cell lines by RNA interference *resulted* in reduced NF-kappaB activity and enhanced MyoD , [myogenin] and MyHC expression and myotube formation . Negative_regulation MYOG TNF 17572510 1774269 We found that IL-10 restores myogenesis by suppressing the ability of exogenous to *inhibit* IGF-I induced [myogenin] . Negative_regulation MYOG TNF 9438136 474961 In contrast , strongly *inhibited* the expression of those myogenic transcription factors ( myoD and [myogenin] ) , which are known to be responsible for upregulated activity of muscle specific genes ( like the genes of the myofilament proteins ) , and blocked the synthesis of mRNAs of myogenic differentiation markers ( like skeletal alpha-actin , myosin heavy and light chains ) . Negative_regulation NA EPHB2 18523380 1965731 PD98059 , a specific *inhibitor* of extracellular signal regulated kinase ( ) , and [N-acetylcysteine (NAC)] , an antioxidant , partially abrogated the stretch induced ICAM-1 protein upregulation at the 3-hour loading . Negative_regulation NA TNF 23319318 2733174 *increased* tyrosine phosphorylation of Syk , which was attenuated by [NAC] and MPA . Negative_regulation NAGLU IL1B 1649133 160899 significantly *suppressed* the release of [NAG] and superoxide by synovial cells , whereas it significantly enhanced the production of NAG and superoxide by chondrocytes . Negative_regulation NAMPT GNE 24097869 2878841 We use a [NAMPT] *inhibitor* , , to evaluate nicotinic acid rescue status in a panel of more than 400 cancer cell lines . Negative_regulation NAMPT GNE 24204194 2864523 A key enzyme in the NAD salvage pathway is nicotinamide phosphoribosyl transferase ( NAMPT ) , and here , we describe , an [NAMPT] *inhibitor* that depletes NAD and induces cell death in vitro and in vivo . Negative_regulation NAMPT GNE 24403854 2884061 To confirm the latter , we tested novel [NAMPT] *inhibitors* , and GNE-618 , in cell culture- and patient derived tumor models . Negative_regulation NANOG FOXA1 19916800 2306996 Furthermore , overexpression of alone in P19 cells stimulates expression of Nestin and *results* in decreased protein levels of [Nanog] . Negative_regulation NANOG FOXA1 24803390 2950598 To study whether Foxa1 participates in the repression of pluripotency factors , we expressed Foxa1 ectopically in P19 cells and identified that [Nanog] was *repressed* directly by . Negative_regulation NANOS2 ARSA 16105666 1454186 NO-ASA also decreased the corresponding steady-state mRNA levels and this reduction preceded the reduction of protein levels by at least 6 h. also *reduced* the enzymatic activity of [NOS2] , as determined by a direct enzyme assay ( maximal reduction = 80 % ) and by determining the accumulation of NO in the culture medium ( IC50 for this effect = 36 microM ) . Negative_regulation NANOS2 ARSA 16105666 1454188 These findings indicate that profoundly *inhibits* both the expression and enzymatic activity of [NOS2] and suggest that these effects may represent an important mechanism for the colon cancer chemopreventive effect of NO-ASA . Negative_regulation NANOS2 IL1B 11530235 853791 However , rotenone inhibited NOS-2 and COX-2 proteins and associated nitric oxide and prostaglandin E ( 2 ) production , respectively , suggesting a posttranscriptional target for *mediated* regulation of [NOS-2] and COX-2 gene expression . Negative_regulation NANOS3 PDE5A 21421555 2416745 Treatment of human endothelium with PDE5A inhibitors resulted in a significant increase in NOS3 activity , whereas overexpression of using an adenoviral vector , both in vivo and in cell culture , *resulted* in decreased [NOS3] activity and endothelium dependent vasodilation . Negative_regulation NANOS3 TNF 22566503 2596432 Inhibition of Rho GTPase with 0.05 µg/mL of C3 exoenzyme blocked *induced* reductions in [NOS3] expression by 30 ± 8 % ( P < 0.02 ) . Negative_regulation NANOS3 TNF 22566503 2596435 Inhibition of ROCK with 10 µmol/L of H-1152 blocked *induced* decreases in [NOS3] expression by 66 ± 15 % ( P < 0.001 ) . Negative_regulation NANOS3 TNF 22566503 2596436 Myosin light chain kinase , NO , protein kinase C , mitogen activated kinase kinase , c-Jun amino terminal kinases , and Rac-1 were also not involved in *induced* decreases in [NOS3] expression . Negative_regulation NANOS3 TNF 8532063 338494 *reduces* the expression of [NOS III] by a post-transcriptional mechanism destabilizing the mRNA . Negative_regulation NAPA MMP28 19414384 2075417 When breast cancer cells were treated with [NaPa] in the *presence* of an inhibitor ( GM6001 ) , apoptotic cell death decreased and the induction of autophagic vacuoles in MDA-MB-231 cells was inhibited . Negative_regulation NAPA MMP7 19414384 2075432 When breast cancer cells were treated with [NaPa] in the *presence* of an inhibitor ( GM6001 ) , apoptotic cell death decreased and the induction of autophagic vacuoles in MDA-MB-231 cells was inhibited . Negative_regulation NBL1 MSX1 11607250 177628 We also found that *induced* dissimilatory reduction of [NO3-] to NH4+ in soil and that the NH4+ thus formed had no effect on the rate of NO-3 reduction . Negative_regulation NCAM1 EPHB2 18656513 1972793 Relative *role* of upstream regulators of Akt , and CREB in [NCAM-] and FGF2 mediated signalling . Negative_regulation NCAM2 EPHB2 18656513 1972797 Relative *role* of upstream regulators of Akt , and CREB in [NCAM-] and FGF2 mediated signalling . Negative_regulation NCF1 TNF 12016268 942389 Stimulation of HPAE cells with *resulted* in the phosphorylation of [p47(phox)] and its association with gp91(phox) . Negative_regulation NCF1 TNF 19552846 2099463 and alpha-ZAL pretreatment attenuated the induced p47(phox) mRNA expression by 63.0 % , and also markedly *inhibited* the [p47(phox)] protein expression . Negative_regulation NCF2 TNF 17462995 1750042 Knockdown of PLAGL2 protein inhibited up-regulation of NCF2 transcript , [p67(phox)] protein expression , and subsequent superoxide production in *response* to . Negative_regulation NCOA1 TNF 15231721 1289413 *suppresses* the expression of [steroid receptor coactivator-1] and -2 : a possible mechanism contributing to changes in steroid hormone responsiveness . Negative_regulation NCOA3 CCND1 20642839 2297559 SFN induced the expression of [p21/CIP1] and p27/KIP1 , and *inhibited* the expression of . Negative_regulation NCOA3 CCND1 21980390 2493074 Resveratrol induced cell cycle arrest by up-regulating the expression of [p21/CIP1] , p27/KIP1 and *inhibiting* the expression of . Negative_regulation NCOA3 IFI27 18583941 1953340 Roles of cyclin dependent kinase *inhibitors* , [p21/Cip1] ( p21 ) and p27/Kip1 ( ) in prostate cancer ( PCa ) progression is still not clear . Negative_regulation NCOA3 TNF 24918060 2941881 The levels of [RAC3] expression are up *regulated* by in the inflammatory response . Negative_regulation NDC80 IGFBP1 1710998 158295 IGF-I receptor binding to [HEC 1B] and KLE cells was inhibited in the *presence* of purified . Negative_regulation NDE1 TNF 22025632 2508065 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation NDEL1 TNF 22025632 2508066 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation NEDD9 CALCA 10455189 638625 Phorbol 12-myristate 13-acetate also induced [HEF1] tyrosine phosphorylation , and the protein kinase C inhibitor calphostin C completely *inhibited* both and phorbol 12-myristate 13-acetate stimulated HEF1 phosphorylation . Negative_regulation NEDD9 CD9 24466195 2907759 Finally , gene depletion of *resulted* in elevated protein levels and tyrosine phosphorylation of FAK and [Cas-L] , which are downstream of ß1 integrin , while depletion of CD26 led to a reduction in the levels of these molecules . Negative_regulation NEDD9 EGFR 23037767 2698407 Overexpression of constitutively active *caused* tyrosine phosphorylation of [NEDD9] in the absence of integrin stimulation . Negative_regulation NEDD9 FCGR1A 9820532 547549 cross linking of U937IF cells *results* in the tyrosine phosphorylation of Cbl , Crkl , and [Hef-1] , an increase in the association of Crkl with Cbl via direct SH2 domain interaction and increased Crkl-Hef-1 binding . Negative_regulation NEDD9 GSK3B 19159680 2038229 This novel function of lithium does not involve inhibition of a well characterized lithium target , GSK3beta , since other known inhibitors do not *induce* [p105] degradation or Tpl2 activation . Negative_regulation NEDD9 MAP3K8 9950430 589759 Furthermore , kinase-inactive *blocks* the degradation of [p105] induced by tumour-necrosis factor-alpha . Negative_regulation NEDD9 MAPK1 10954702 744361 Furthermore , inhibition of Erk1 and phosphorylation *had* no effect on the calcitonin induced phosphorylation of paxillin and [HEF1] . Negative_regulation NEDD9 MAPK3 10954702 744362 Furthermore , inhibition of and Erk2 phosphorylation *had* no effect on the calcitonin induced phosphorylation of paxillin and [HEF1] . Negative_regulation NEDD9 PPP2CA 19539609 2128678 In the HCT-116 cell line transiently overexpressing Flag-HEF1 we showed that Hesperadin , a synthetic indolinone displaying antiproliferative effect and described as an inhibitor of various kinases including Aurora-B , prevented [HEF1] phosphorylation *induced* by the ser/thr phosphatase inhibitor : okadaic acid ( OA ) . Negative_regulation NEDD9 PPP2R1A 19539609 2128679 In the HCT-116 cell line transiently overexpressing Flag-HEF1 we showed that Hesperadin , a synthetic indolinone displaying antiproliferative effect and described as an inhibitor of various kinases including Aurora-B , prevented [HEF1] phosphorylation *induced* by the ser/thr phosphatase inhibitor : okadaic acid ( OA ) . Negative_regulation NEDD9 PPP2R2B 19539609 2128680 In the HCT-116 cell line transiently overexpressing Flag-HEF1 we showed that Hesperadin , a synthetic indolinone displaying antiproliferative effect and described as an inhibitor of various kinases including Aurora-B , prevented [HEF1] phosphorylation *induced* by the ser/thr phosphatase inhibitor : okadaic acid ( OA ) . Negative_regulation NEDD9 SP1 9151857 430867 To address the specific *role* of in p65 and [p105/p50] promoter transactivation by HCMV , we mutated both promoters . Negative_regulation NEDD9 SRC 10954702 744351 Overexpression of wild-type *increased* calcitonin induced paxillin and [HEF1] phosphorylation , whereas overexpression of kinase-dead Src or Src lacking a functional SH2 domain inhibited the calcitonin stimulated tyrosine phosphorylation of these proteins . Negative_regulation NEDD9 TGFB1 12189134 992637 promoted HEF1 expression in a dose dependent manner and *resulted* in a 16-fold increase in [HEF1] protein level . Negative_regulation NEDD9 WNK1 19278579 2046328 It was shown that RNAi targeting IKKalpha and IKKgamma could down-regulate the expression of IKKalpha and IKKgamma genes , and at the same time , down-regulate the expression of NF-KappaB p65 , p50 and [p105] proteins both in cytoplasm and nucleus , and *inhibit* the nuclear translocation of NF-KappaB , p50 and p105 proteins . Negative_regulation NELFCD JAG1 12077232 957028 We conclude that injected into the anterior chamber of the eye *impair* both [Th1] and Th2 responses . Negative_regulation NELFCD SELL 20182448 2248642 We attempted to determine the *role* of and ICAM-1 in [Th1-] and Th2-type CHS induced by DNFB or FITC in mice lacking either L-selectin , ICAM-1 , or both . Negative_regulation NELFCD STAT4 23772023 2807564 Opposing *roles* of and Dnmt3a in [Th1] gene regulation . Negative_regulation NELFCD TNF 9550429 477816 Suppression of expression , *inhibition* of [Th1] activity , and amelioration of collagen induced arthritis by rolipram . Negative_regulation NES ADCYAP1 23900722 2839988 We also found that or VIP prevented GFAP decrease caused by CR and further *reduced* the expression of [nestin] , a prognostic marker of malignancy . Negative_regulation NES CD46 20814749 2346049 Furthermore , overexpression of in Ink4a/Arf ( -/- ) astrocytes inhibited cell migration and invasion and *promoted* neurosphere formation and [Nestin] expression , which are hallmark characteristics of glioma stem cells , under stem cell culture conditions . Negative_regulation NES CDC25C 11313932 805952 However , complete nuclear accumulation of *required* loss of both [NES] function and 14-3-3 binding and this was accomplished both pharmacologically and by mutation . Negative_regulation NES EGF 20735994 2324338 deprivation *increased* the number of apoptotic cells , decreased expression of [nestin] , and increased expression of GFAP . Negative_regulation NES EPO 21044627 2376311 By using immunohistochemical markers of different NSC maturation stages , we show that *increased* the number of [nestin] ( + ) cells in the dentate gyrus and in the sub-ventricular zone of the lateral ventricles , relative to control-treatment . Negative_regulation NES FOXA1 19916800 2306997 Furthermore , overexpression of alone in P19 cells *stimulates* expression of [Nestin] and results in decreased protein levels of Nanog . Negative_regulation NES GCG 17366624 1727467 In addition , the lack of signaling *increased* [nestin] mRNA levels in pancreas of mutant embryos and adult mice . Negative_regulation NES MAP2 11161610 782058 We showed that cell division and expression of nestin persists at 33 degrees C , the permissive temperature , whereas cell division ceases , [nestin] expression decreases , and expression *increases* at the nonpermissive temperature of 39 degrees C . Negative_regulation NES MAPK1 15269220 1296109 Finally , we demonstrate that the ability of MKP-3 to cause the cytoplasmic retention of *requires* both a functional kinase interaction motif and [NES] . Negative_regulation NES MARCH8 23016664 2702307 targeted the 3'-UTR of Nestin and *reduced* the abundance of [Nestin] at both mRNA and protein levels . Negative_regulation NES MYLIP 23572380 2789376 We found that over-expression of suppressed proliferation and *down-regulated* Notch2 protein and stem cell marker ( CD133 and [Nestin] ) expression in U87GSCs . Negative_regulation NES NOTCH1 15246688 1271058 We also show that [nestin] loss is *regulated* by , and mediated by cell contact . Negative_regulation NES NOTCH2 15246688 1271059 We also show that [nestin] loss is *regulated* by , and mediated by cell contact . Negative_regulation NES NOTCH3 15246688 1271060 We also show that [nestin] loss is *regulated* by , and mediated by cell contact . Negative_regulation NES NOTCH4 15246688 1271061 We also show that [nestin] loss is *regulated* by , and mediated by cell contact . Negative_regulation NES POU5F1 18985733 2053349 Overexpression of in C6 cells *increased* the expression of [nestin] but decreased the expression of GFAP suggesting that Oct4 might inhibit the differentiation of glioma cells . Negative_regulation NES SLPI 16182289 1462082 *inhibited* both [NEs] , but neither PR3 . Negative_regulation NES SP6 22073883 2504488 EA of ST 36 and can effectively *suppress* splenic asthenia syndrome induced decrease of the numbers of Brdu , Brdu/GFAP , [Brdu/Nestin] and Brdu/NSE IR-positive cells in the DG of hippocampus at the early stage in the splenic asthenia rats , which may contribute to its effect in improving splenic asthenia symptoms in clinic by promoting the proliferation and differentiation of some nerve stem cells in the hippocampus . Negative_regulation NES TNF 25206589 2886978 In vivo experiments showed that 50-200 mg/kg Buyang Huanwu Decoction fraction reduced infarct volume and pathological injury in ischemia/reperfusion rats , markedly *inhibited* expression of nuclear factor-?B and and promoted [nestin] protein expression in brain tissue . Negative_regulation NES VIP 23900722 2839987 We also found that PACAP or prevented GFAP decrease caused by CR and further *reduced* the expression of [nestin] , a prognostic marker of malignancy . Negative_regulation NES VSX2 15893976 1407701 Nestin expression in the retina is restricted to intermediate/late RPC subsets , and genetic evidence is presented that demonstrates that *represses* [Nestin] expression in early RPCs . Negative_regulation NEU1 MAP2K6 16216242 1476478 We also show that the [sialidase] promoter is *repressed* by activated . Negative_regulation NEU1 TNF 12867430 1141919 Blocking production by PD98059 , a p42/44 inhibitor , significantly *reduced* the LPS induced [sialidase] activity and CD44-HA binding . Negative_regulation NEU2 MAP2K6 16216242 1476485 We also show that the [sialidase] promoter is *repressed* by activated . Negative_regulation NEU2 TNF 12867430 1141920 Blocking production by PD98059 , a p42/44 inhibitor , significantly *reduced* the LPS induced [sialidase] activity and CD44-HA binding . Negative_regulation NEU3 MAP2K6 16216242 1476492 We also show that the [sialidase] promoter is *repressed* by activated . Negative_regulation NEU3 TNF 12867430 1141921 Blocking production by PD98059 , a p42/44 inhibitor , significantly *reduced* the LPS induced [sialidase] activity and CD44-HA binding . Negative_regulation NEU4 MAP2K6 16216242 1476471 We also show that the [sialidase] promoter is *repressed* by activated . Negative_regulation NEU4 TNF 12867430 1141918 Blocking production by PD98059 , a p42/44 inhibitor , significantly *reduced* the LPS induced [sialidase] activity and CD44-HA binding . Negative_regulation NEUROD1 ADRB2 9675299 520334 It was also observed that the elevated expression of the in the neuronal NT2 cells *resulted* in an enhanced level of [neuronal differentiation] compared to the wild type cells . Negative_regulation NEUROD1 CABP4 11563845 862960 An MN9D dopaminergic neuronal cell line overexpressing calbindin-D28K ( MN9D/Calbindin ) was established in order to investigate directly the potential *role* of in [neuronal differentiation] . Negative_regulation NEUROD1 CCND1 16569215 1568415 co-operates with INSM1 and *suppresses* [neuroD/beta2] promoter activity . Negative_regulation NEUROD1 CDKN1C 19590511 2117853 In accordance with these observations , gain- and loss-of-function studies showed that *repressed* [neuronal differentiation] after mitogen withdrawal , but exerted little or no effect on CNTF mediated astroglial differentiation of NSCs . Negative_regulation NEUROD1 EPHB2 17976838 1831162 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Negative_regulation NEUROD1 EPHB2 23564461 2789156 The regulation of Ras and signaling by Ser ( 779 ) was *critical* not only for [neuronal differentiation] but also for cell survival under limiting growth factor concentrations . Negative_regulation NEUROD1 IFI27 10837916 699511 Expression and *role* of ( kip1 ) in [neuronal differentiation] of embryonal carcinoma cells . Negative_regulation NEUROD1 IFI27 22973984 2697844 Transient overexpression of in P19 cells also *promoted* [neuronal differentiation] of P19 cells . Negative_regulation NEUROD1 JAG1 19389353 2069950 Bmp4 , and Sox2 expression were largely absent at early stages of sensory development and [NeuroD] expression was *reduced* in the developing vestibulo-acoustic ganglion . Negative_regulation NEUROD1 JAG1 20081190 2194397 Loss of Dll1 or *leads* to a domain-specific increase of [neuronal differentiation] but does not affect the establishment of progenitor domain boundaries . Negative_regulation NEUROD1 MAP2K6 17976838 1831168 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Negative_regulation NEUROD1 MAP2K6 9111053 425448 Overexpression of a constitutively active ( MAPKK or MEK ) *induces* [neuronal differentiation] in adrenal pheochromocytoma 12 cells but transformation in fibroblasts . Negative_regulation NEUROD1 WNT7A 15142975 1252177 Overexpression of or of a stabilized form of beta-catenin in mouse cortical NPC cultures *induced* [neuronal differentiation] even in the presence of Fgf2 , a self-renewal promoting factor in this system . Negative_regulation NEUROD2 ADRB2 9675299 520335 It was also observed that the elevated expression of the in the neuronal NT2 cells *resulted* in an enhanced level of [neuronal differentiation] compared to the wild type cells . Negative_regulation NEUROD2 CABP4 11563845 862965 An MN9D dopaminergic neuronal cell line overexpressing calbindin-D28K ( MN9D/Calbindin ) was established in order to investigate directly the potential *role* of in [neuronal differentiation] . Negative_regulation NEUROD2 CDKN1C 19590511 2117854 In accordance with these observations , gain- and loss-of-function studies showed that *repressed* [neuronal differentiation] after mitogen withdrawal , but exerted little or no effect on CNTF mediated astroglial differentiation of NSCs . Negative_regulation NEUROD2 EPHB2 17976838 1831170 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Negative_regulation NEUROD2 EPHB2 23564461 2789157 The regulation of Ras and signaling by Ser ( 779 ) was *critical* not only for [neuronal differentiation] but also for cell survival under limiting growth factor concentrations . Negative_regulation NEUROD2 IFI27 10837916 699512 Expression and *role* of ( kip1 ) in [neuronal differentiation] of embryonal carcinoma cells . Negative_regulation NEUROD2 IFI27 22973984 2697846 Transient overexpression of in P19 cells also *promoted* [neuronal differentiation] of P19 cells . Negative_regulation NEUROD2 JAG1 20081190 2194399 Loss of Dll1 or *leads* to a domain-specific increase of [neuronal differentiation] but does not affect the establishment of progenitor domain boundaries . Negative_regulation NEUROD2 MAP2K6 17976838 1831176 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Negative_regulation NEUROD2 MAP2K6 9111053 425455 Overexpression of a constitutively active ( MAPKK or MEK ) *induces* [neuronal differentiation] in adrenal pheochromocytoma 12 cells but transformation in fibroblasts . Negative_regulation NEUROD2 WNT7A 15142975 1252179 Overexpression of or of a stabilized form of beta-catenin in mouse cortical NPC cultures *induced* [neuronal differentiation] even in the presence of Fgf2 , a self-renewal promoting factor in this system . Negative_regulation NEUROD4 ADRB2 9675299 520332 It was also observed that the elevated expression of the in the neuronal NT2 cells *resulted* in an enhanced level of [neuronal differentiation] compared to the wild type cells . Negative_regulation NEUROD4 CABP4 11563845 862950 An MN9D dopaminergic neuronal cell line overexpressing calbindin-D28K ( MN9D/Calbindin ) was established in order to investigate directly the potential *role* of in [neuronal differentiation] . Negative_regulation NEUROD4 CDKN1C 19590511 2117851 In accordance with these observations , gain- and loss-of-function studies showed that *repressed* [neuronal differentiation] after mitogen withdrawal , but exerted little or no effect on CNTF mediated astroglial differentiation of NSCs . Negative_regulation NEUROD4 EPHB2 17976838 1831146 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Negative_regulation NEUROD4 EPHB2 23564461 2789154 The regulation of Ras and signaling by Ser ( 779 ) was *critical* not only for [neuronal differentiation] but also for cell survival under limiting growth factor concentrations . Negative_regulation NEUROD4 IFI27 10837916 699509 Expression and *role* of ( kip1 ) in [neuronal differentiation] of embryonal carcinoma cells . Negative_regulation NEUROD4 IFI27 22973984 2697840 Transient overexpression of in P19 cells also *promoted* [neuronal differentiation] of P19 cells . Negative_regulation NEUROD4 JAG1 20081190 2194393 Loss of Dll1 or *leads* to a domain-specific increase of [neuronal differentiation] but does not affect the establishment of progenitor domain boundaries . Negative_regulation NEUROD4 MAP2K6 17976838 1831152 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Negative_regulation NEUROD4 MAP2K6 9111053 425406 Overexpression of a constitutively active ( MAPKK or MEK ) *induces* [neuronal differentiation] in adrenal pheochromocytoma 12 cells but transformation in fibroblasts . Negative_regulation NEUROD4 WNT7A 15142975 1252168 Overexpression of or of a stabilized form of beta-catenin in mouse cortical NPC cultures *induced* [neuronal differentiation] even in the presence of Fgf2 , a self-renewal promoting factor in this system . Negative_regulation NEUROD6 ADRB2 9675299 520333 It was also observed that the elevated expression of the in the neuronal NT2 cells *resulted* in an enhanced level of [neuronal differentiation] compared to the wild type cells . Negative_regulation NEUROD6 CABP4 11563845 862955 An MN9D dopaminergic neuronal cell line overexpressing calbindin-D28K ( MN9D/Calbindin ) was established in order to investigate directly the potential *role* of in [neuronal differentiation] . Negative_regulation NEUROD6 CDKN1C 19590511 2117852 In accordance with these observations , gain- and loss-of-function studies showed that *repressed* [neuronal differentiation] after mitogen withdrawal , but exerted little or no effect on CNTF mediated astroglial differentiation of NSCs . Negative_regulation NEUROD6 EPHB2 17976838 1831154 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Negative_regulation NEUROD6 EPHB2 23564461 2789155 The regulation of Ras and signaling by Ser ( 779 ) was *critical* not only for [neuronal differentiation] but also for cell survival under limiting growth factor concentrations . Negative_regulation NEUROD6 IFI27 10837916 699510 Expression and *role* of ( kip1 ) in [neuronal differentiation] of embryonal carcinoma cells . Negative_regulation NEUROD6 IFI27 22973984 2697842 Transient overexpression of in P19 cells also *promoted* [neuronal differentiation] of P19 cells . Negative_regulation NEUROD6 JAG1 20081190 2194395 Loss of Dll1 or *leads* to a domain-specific increase of [neuronal differentiation] but does not affect the establishment of progenitor domain boundaries . Negative_regulation NEUROD6 MAP2K6 17976838 1831160 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Negative_regulation NEUROD6 MAP2K6 9111053 425413 Overexpression of a constitutively active ( MAPKK or MEK ) *induces* [neuronal differentiation] in adrenal pheochromocytoma 12 cells but transformation in fibroblasts . Negative_regulation NEUROD6 WNT7A 15142975 1252170 Overexpression of or of a stabilized form of beta-catenin in mouse cortical NPC cultures *induced* [neuronal differentiation] even in the presence of Fgf2 , a self-renewal promoting factor in this system . Negative_regulation NEUROG1 MAP2K6 23902762 2844680 Meanwhile , an inhibitor ( U0126 ) *recovered* sox2 and [ngn1] transcript levels in cdk10 morphants . Negative_regulation NF2 EPHB2 18332868 1925110 Consistently , VprBP depletion abolished the in vivo interaction of [Merlin] and Roc1-Cullin4A-DDB1 , which resulted in Merlin stabilization and *inhibited* and Rac activation . Negative_regulation NFASC CNTNAP1 14676309 1178954 regulates the processing of contactin and *inhibits* its binding to [neurofascin] . Negative_regulation NFATC1 EPHB2 20112358 2206305 IL-27 inhibited human osteoclastogenesis , suppressed the induction of [NFATc1] , down-regulated the expression of RANK and triggering receptor expressed on myeloid cells 2 ( TREM-2 ) , and *inhibited* RANKL mediated activation of , p38 , and NF-kappaB in osteoclast precursors . Negative_regulation NFATC1 RCAN1 15448146 1334968 Constitutive expression of in endothelial cells markedly *impaired* [NF-ATc] nuclear localization , proliferation , and tube formation . Negative_regulation NFATC2 IL1B 20424162 2274555 also *causes* increased expression of C/EBP-beta and a reduction of MafA , [NFATc2] , and Pdx-1 expression in beta cells . Negative_regulation NFATC4 FBXO32 15489953 1321337 Moreover , attenuates agonist induced calcineurin activity and *represses* calcineurin dependent transactivation and [NFATc4] translocation . Negative_regulation NFE2L2 EPHB2 21270272 2380793 *mediated* suppression of [Nrf2] activity leads to the oxidative stress induced insulin resistance in adult cardiomyocytes and downregulated glucose utilization in the diabetic heart . Negative_regulation NFE2L2 EPHB2 23776571 2802256 Interestingly , MEK inhibitor abrogated its nuclear translocation suggesting *role* of in basal and radiation induced [Nrf-2] activation in tumor cells . Negative_regulation NFE2L2 MAP2K6 16155909 1499497 Furthermore , inhibitors *increased* nuclear [Nrf2] and Nrf2/ARE binding . Negative_regulation NFE2L2 MAP2K6 24646717 2925823 The pharmacological inhibition of , but not of p38 mitogen activated protein kinase , glycogen synthase kinase-3 or phosphoinositide 3-kinase was *required* for the activation of Nrf2 dependent gene expression by pau d'arco , but not for the nuclear translocation of [Nrf2] . Negative_regulation NFIC TNF 19135070 2031960 *reduced* the alcohol vulnerability of immature neurons , while [NFi] increased the vulnerability of mature neurons . Negative_regulation NFKB1 ANGPT1 17085463 1685083 mediated *inhibition* of increased [NF-kappaB-DNA] binding in nuclear extracts from HUVECs grown in high glucose was significantly blocked by soluble Tie2 receptor-Fc . Negative_regulation NFKB1 ANGPT1 20060382 2205435 We further investigated the mechanism and found that could *block* LPS induced activation of [NF-kappaB] which has been shown to be necessary for macrophage activation with LPS treatment . Negative_regulation NFKB1 ARSA 10602313 574668 4. In contrast , <5ASA> and sulfapyridine neither *inhibit* [NF-kappaB/Rel] activation nor induce apoptosis in T-lymphocytes at doses up to 5.0 mM . Negative_regulation NFKB1 ARSA 10602313 574671 5. These results demonstrate that sulfasalazine , but not <5ASA> or sulfapyridine , strongly *inhibits* [NF-kappaB] activation and potently induces apoptosis in T-lymphocytes . Negative_regulation NFKB1 ARSA 11133489 769141 *inhibited* TNF-alpha induced activation of [NF-kappa B] by preventing phosphorylation and subsequent degradation of I kappa B-alpha in a prostanoid independent manner . Negative_regulation NFKB1 ARSA 11775855 581320 Both DEX and could *inhibit* the activation of [NF-kappa B] and reduce the release of TNF-alpha . Negative_regulation NFKB1 ARSA 15085062 1234483 LDL induced activation of the transcription factor [NF-kappaB] was *inhibited* by , and ferritin protein was increased when endothelial cells were incubated with this drug . Negative_regulation NFKB1 ARSA 15763541 1383551 Concomitantly , *inhibited* [nuclear factor (NF)-kappaB] activity , as well as the phosphorylation and breakdown of the inhibitory protein IkappaB-alpha . Negative_regulation NFKB1 ARSA 15909110 1409484 SFZ , but not <5-ASA> or SPY , *inhibits* activation of [NF-kB] . Negative_regulation NFKB1 ARSA 16199534 1483157 Biochemical analysis revealed that *inhibited* [NF-kappaB] activity , which is known to regulate BCL-2 gene expression , by dephosphorylating IkappaB-alpha and inhibiting IKKbeta activity but not by affecting the HER-2/neu phosphatidylinositol 3-kinase-Akt signal pathway . Negative_regulation NFKB1 ARSA 17644113 1865902 Although , itself had no effect on the NF-kappaB pathway , nor did it *reduce* DC-induced [NF-kappaB] translocation , it did prevent DC-induced caspase-3 , -6 and -9 activation , poly ( ADP-ribose ) polymerase and lamin A processing , DNA degradation , and PKC signaling , all indices of apoptosis . Negative_regulation NFKB1 ARSA 9808189 545153 Analysis of the regulation of the p40 gene promoter revealed that *inhibited* [NF-kappaB] activation and binding to the p40-kappaB site in the p40 promoter , leading to transcriptional repression of the p40 gene . Negative_regulation NFKB1 BPI 17239348 1690525 Although the functional mechanism whereby extra-cellular BPI modulates the intra-cellular signal pathways selected by the TLR adaptors , MyD88 and TICAM-1 ( TRIF ) , remains unknown , we infer that the lipid A portion of LPS participates in LBP amplified IFN-beta induction and that binding to LPS *leads* to inhibition of the activation of [NF-kappaB] and IFN-beta by LPS or agonistic lipid A via TLR4 in an extrinsic mode . Negative_regulation NFKB1 CAPN8 17323976 1711852 It reduces mitochondrial membrane potential by activating and *inhibits* [NF-kappaB] activity by increasing the ROS level . Negative_regulation NFKB1 CCND1 19471891 2085385 [NF-kappaB] target gene expression of apoptotic cell death proteins ( Bax , caspase-3 , caspase-9 ) was significantly enhanced , but the expression of anti-apoptotic genes and cell proliferation marker genes ( Bcl-2 , inhibitor of apoptosis protein ( IAP-1 ) and X chromosome IAP (XIAP) , Cox-2 , c-Fos , c-Jun and ) was significantly *inhibited* by the combined treatment compared to Rg3 or docetaxel alone . Negative_regulation NFKB1 CCND1 20596608 2286038 Pre-treatment of NS3 protein expressing cells with ERK inhibitor , PD98059 , blocked the activation of AP-1 and [NF-kappaB] , and *inhibited* expression and cell proliferation . Negative_regulation NFKB1 CD14 11380692 820520 An approximately 70 % decrease of lipopeptide induced [NFkappaB] translocation and an about 50 % reduction of nitric oxide ( NO ) release was observed in the *presence* of . Negative_regulation NFKB1 CD14 15618154 1357611 Here , we report that human high-dose LBP ( hd-LBP ) suppresses binding of both R-type and S-type LPS to and *inhibits* LPS induced nuclear translocation of [NF-kappaB] , although cellular uptake of R-type LPS was found to be increased by hd-LBP . Negative_regulation NFKB1 CD14 16879219 1593847 Antirat and antirat TLR-4 antibodies *inhibited* LPS induced [NFkappaB] activation , and a NFkappaB inhibitor suppressed LPS induced decreased PS expression in both cells . Negative_regulation NFKB1 CLU 12882985 1142757 Ectopic expression strongly *inhibited* [NF-kappaB] activity in human neuroblastoma cells and murine embryonic fibroblasts by stabilizing inhibitors of NF-kappaB ( IkappaBs ) . Negative_regulation NFKB1 CLU 17359935 1712670 Presence of *reduced* [NF-kappaB] activation and expression of the NF-kappaB target genes TNF-alpha and MOB-1 under cell stress . Negative_regulation NFKB1 EDN2 19616538 2124181 Ghrelin also significantly suppressed interleukin-1beta , tumor necrosis factor-alpha , and mRNA expression , and *inhibited* [NF-kappaB] activation . Negative_regulation NFKB1 EPHB2 15249201 1271356 However , in the *presence* of PD98,059 , an inhibitor of , and salicylic acid , an [NF-kappaB] inhibitor , the EPO induced morphological differentiation of astrocytes and expression of FGAP and EPO receptor were reduced . Negative_regulation NFKB1 EPHB2 16242916 1532015 Consistently , inhibition of significantly *increased* IkappaB kinase (IKK) activity , IkappaBalpha phosphorylation , and nuclear translocation of [NF-kappaB] induced by VEGF , whereas overexpression of ERK resulted in the loss of these responses to VEGF . Negative_regulation NFKB1 EPHB2 17322771 1706385 In addition , inhibitor , PD 98,059 , reversed BPA induced cell death and *restored* [NF-kappaB] activity . Negative_regulation NFKB1 EPHB2 18442799 1900629 In this study , we show that and p38 MAP kinase are *involved* in the downregulation of cell surface TNF-R1 upon exposure to Ac-CHX and the subsequent inhibition of TNF-alpha induced [NF-kappaB] activation . Negative_regulation NFKB1 EPHB2 19127075 2071301 Analysis of the signaling pathways responsible for RANTES production by Langerhans cells was performed by ELISA using N-acetyl-L-cysteine , SP600125 , SB203580 and PD98059 , which are specific *inhibitors* of [NF-kappaB] activation , JNK , p38 MAPK and , respectively , and was finally confirmed by Western blot analysis . Negative_regulation NFKB1 EPHB2 19823174 2187300 Sulfur dioxide donor significantly downregulated Raf-1 , mitogen activated protein kinase kinase-1 ( MEK-1 ) and , and *inhibited* pulmonary vascular smooth muscle cell proliferation , collagen remodeling and pulmonary vascular endothelial cell [nuclear factor-kappaB (NF-kappaB)] , and intercellular adhesion molecule 1 ( ICAM-1 ) expressions . Negative_regulation NFKB1 EPHB2 20093109 2226139 We also found that markedly *suppressed* [NF-kappaB] signaling as detected by the NF-kappaB reporter gene assay but had no effects on the degradation of IkappaBalpha or translocation of NF-kappaB . Negative_regulation NFKB1 EPHB2 20403072 2282174 inhibition also *induced* I-kappaB phosphorylation and enhanced [nuclear factor (NF)-kappaB/DNA] binding activity , leading to expression of cellular inhibitors of apoptosis protein 2 ( c-IAP2 ) , a known nuclear factor-kappaB (NF-kappaB) regulated endogenous anti-apoptotic molecule . Negative_regulation NFKB1 EPHB2 20537708 2279370 In conclusion , all these findings demonstrate a key *role* of and TLR4 in association with [NF-kappaB] in IL-10 modulation induced by T. cruzi and suggest that this regulatory effect involves parasite-DC interactions not described yet . Negative_regulation NFKB1 EPHB2 9092580 422121 Inhibition of tyrosine kinase activity with genistein ( 10 microg/ml ) as well as selective MAP kinase inhibition with the MEK-1 inhibitor PD98059 abolished the VLA-4 dependent tyrosine phosphorylation , *inhibited* [NF kappaB] nuclear binding , and abrogated tissue factor expression induced by both VLA-4 cross linking and adhesion to fibronectin in THP-1 cells and human peripheral blood monocytes . Negative_regulation NFKB1 F2R 16467309 1548171 Activation of or PAR-2 promoted nuclear translocation and phosphorylation of p65-NF-kappaB , and thrombin induced but not PAR-2 induced [p65-NF-kappaB] phosphorylation was *reduced* by inhibition of MEK or p38MAPK . Negative_regulation NFKB1 FAS 10580567 570097 Modulation of expression and *inhibition* of [NF-kappaB] activation can potentially be of therapeutic importance in multiple myeloma . Negative_regulation NFKB1 FAS 11585763 866265 Neither pathway activation alone nor *inhibition* of [NF-kappaB] activity with IkappaB-super repressor was sufficient to induce apoptosis of prostate cancer cells . Negative_regulation NFKB1 FAS 12855571 1149814 Importantly , up-regulation of Gadd45 beta by CD40 precedes *induced* caspase activation , as well as up-regulation of other [NF-kappa B-controlled] inhibitors of apoptosis such as Bcl-xL and c-FLIPL . Negative_regulation NFKB1 FAS 12883671 1116460 However , the *role* of in induction of [NF-kappaB] activation in HCC cells is not well understood . Negative_regulation NFKB1 FAS 12897127 1118131 Interestingly , a 59-amino-acid core that included NLS2 but not the C-terminal leucine zipper domain was necessary and sufficient to induce pathway activation , *inhibition* of [NF-kappaB] activity , and apoptosis . Negative_regulation NFKB1 FAS 15117910 1252040 Hcy increased [NF-kappaB] DNA binding activity , and adenovirus mediated transfection of a Ikappa-B mutant ( Ikappa-B mt ) gene *inhibited* Hcy induced expression . Negative_regulation NFKB1 FAS 16765090 1612551 ( CD95 ) ligation *inhibits* activation of [NF-kappa B] by targeting p65-Rel A in a caspase dependent manner . Negative_regulation NFKB1 FAS 18039530 1828541 Of the several molecular targets , those receiving attention are p53 gene replacement , Bcl-2 downregulation , apoptosis by induced by TNF , the receptor system and TRAIL , and *inhibition* of [NF-kappaB] . Negative_regulation NFKB1 FAS 9500443 490761 We demonstrate that ligation of ( Fas/APO1 ) , a potent apoptotic stimulus in lymphocytes , *results* in repression of [NF-kappaB] activity in Jurkat T cells by inducing the proteolytic cleavage of NF-kappaB p65 ( Rel A ) and p50 . Negative_regulation NFKB1 FUT4 17410536 1736211 In an attempt to identify an effective therapeutic agent for pancreatic cancer , the authors studied the *role* of , a synthetic serine protease inhibitor , in the inhibition of [NF-kappaB] activation and the induction of apoptotic responses . Negative_regulation NFKB1 FUT4 17410536 1736299 In a time dependent and dose dependent manner , *inhibited* IkappaBalpha phosphorylation and [NF-kappaB] activation , thereby inhibiting the antiapoptotic activity of NF-kappaB . Negative_regulation NFKB1 HBEGF 16034135 1436445 Neither overexpression or inhibition of MEK , Ras , or Akt affected *mediated* inhibition of [NF-kappaB] activation . Negative_regulation NFKB1 HES2 15836676 1397684 Similarly , could *inhibit* hepatic [NF-kappaB] and AP-1 activations . Negative_regulation NFKB1 HES2 15943182 1415833 also down-regulated pulmonary proinflammatory cytokines ( TNF-alpha , IL-1beta , and IL-6 ) and mRNA expressions ( CINC and P-selectin ) , and *inhibited* pulmonary activities of [NF-kappaB] and AP-1 . Negative_regulation NFKB1 HES2 16104441 1444721 also decreased the number of MPO positive cells induced by LPS and *inhibited* activation of [NF-kappaB] and AP-1 . Negative_regulation NFKB1 HES2 16987337 1617809 130/0.4 can *inhibit* CLP induced neutrophil recruitment and subsequent ALI by attenuating cytokines/chemokines , adhesion molecule mediated inflammation and [NF-kappaB] activation . Negative_regulation NFKB1 HES2 19166983 2038561 In addition , both and BL could *attenuate* the increase in TNF-alpha , IL-6 , MPO levels and [NF-kappaB] activation . Negative_regulation NFKB1 HES2 19766237 2224576 also significantly *inhibited* [NF-kappaB] activation , and TLRs mRNA and protein levels in peripheral monocytes . Negative_regulation NFKB1 HES2 20451670 2288436 Meanwhile , could significantly reduce TNF-alpha , IL-6 , and ICAM-1 mRNA , *inhibit* [NF-kappaB] activation , and down-regulate TLR2 and TLR4 expression in the brain . Negative_regulation NFKB1 ID1 17012234 1641400 Here , by using a T cell line model , we demonstrate that expression *stimulates* basal levels of [NF-kappaB] activity and further enhances NF-kappaB activation upon T cell receptor ( TCR ) signaling achieved by anti-CD3 and anti-CD28 stimulation . Negative_regulation NFKB1 IFI27 17702989 1788789 Overexpression of *enhanced* the LPS induced IkappaB-zeta , IL-12p40 and [NF-kappaB] promoter activities , while anti-sense ( AS ) RNA against Ifi202 strongly suppressed them in a monocytic cell line , RAW 264.7 . Negative_regulation NFKB1 IGFBP1 9575170 502602 This differential induction of iNOS as compared with similar *activation* of [NF-kappaB] by inhibitors of indicates the involvement of different intracellular signaling events for the induction of iNOS in two cell types of the same animal species . Negative_regulation NFKB1 IL1B 11445585 860060 Furthermore , lambda/iotaPKC and cPLA(2) phosphorylation was attenuated by phosphatidyinositol 3-kinase ( PI3-kinase ) inhibitors , which also reduced [NF-kappaB] activation in *response* to TNF-alpha and , indicating a role for PI3-kinase in these processes in human keratinocytes . Negative_regulation NFKB1 IL1B 11976320 953993 CaMKKc and Akt overexpression decreases IRAK1 mediated [NF-kappaB] activity and its association with MyD88 in *response* to stimulation . Negative_regulation NFKB1 IL1B 14503852 1144639 Astaxanthin also suppressed the serum levels of NO , PGE2 , TNF-alpha , and in LPS administrated mice , and *inhibited* [NF-kappaB] activation as well as iNOS promoter activity in RAW264.7 cells stimulated with LPS . Negative_regulation NFKB1 IL1B 16148608 1455208 induced NF-kappaB activation in vascular smooth muscle cells , and the addition of GGA further *inhibited* this [NF-kappaB] activation . Negative_regulation NFKB1 IL1B 16286467 1509597 induced H2O2 production in MCF-7 cells and clearance of this ROS through the expression of GPx-1 *reduced* [NFkappaB] transcriptional activation by inhibiting NIK mediated phosphorylation of IKKalpha . Negative_regulation NFKB1 IL1B 16675961 1583970 Concomitantly , we demonstrated that EFs stimulation *induced* [NF-kappaB] nuclear translocation and DNA binding on IL-1beta promoter region whereas inhibition of NF-kappaB with the specific chemical inhibitor SN-50 or by overexpression of IkappaB , the endogenous inhibitor of NF-kappaB pathway , totally abolished EFs mediated mRNA overexpression . Negative_regulation NFKB1 IL1B 16707097 1564045 *activated* the extracellular signal regulated kinase 1/2 ( ERK1/2 ) , and this activation was also enhanced by H ( 2 ) S. Inhibition of ERK1/2 activation by the selective inhibitor U0126 inhibited IL-1beta induced [NF-kappaB] activation , iNOS expression , and NO production either in the absence or presence of H ( 2 ) S . Negative_regulation NFKB1 IL1B 17115116 1709117 Resveratrol , a polyphenolic , natural phytoalexin found with particularly high levels in grape skin and red wine is potent and specific inhibitor of TNF-alpha and *induced* [NF-kappaB] activation . Negative_regulation NFKB1 IL1B 17136479 1747051 Investigation of *mediated* regulation of [NF-kappaB] activation in colonic cells reveals divergence between PKB and PDK transduced events . Negative_regulation NFKB1 IL1B 17931811 1819692 In lipopolysaccharide (LPS) stimulated RAW264.7 cells , HMCO5 inhibited [NF-kappaB] activation as well as iNOS promoter activity , *inhibited* the secretion of TNF-alpha and , and directly inhibited the intracellular accumulation of reactive oxygen species . Negative_regulation NFKB1 IL1B 18266467 1896057 Here we demonstrate that ectopic expression of B14 inhibited [NF-kappaB] activation in *response* to TNFalpha , , poly ( I:C ) , and PMA . Negative_regulation NFKB1 IL1B 18669445 1973127 DPML significantly inhibited tumor necrosis factor alpha , , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* [NFkappaB] and p38 mitogen activated protein kinase activation in the lung . Negative_regulation NFKB1 IL1B 18779659 1963173 The stimulation of lymphoid cells with TNF-alpha , , and LPS *resulted* in significant ROS production and [NF-kappaB] activation . Negative_regulation NFKB1 IL1B 19273233 2045824 In vitro experiments showed that stimulation also significantly *reduced* the association of Tollip with IRAK-1 and increased [NF-kappaB] binding activity in neonatal cardiomyocytes . Negative_regulation NFKB1 IL1B 19616538 2124183 Ghrelin also significantly suppressed , tumor necrosis factor-alpha , and endothelin-l mRNA expression , and *inhibited* [NF-kappaB] activation . Negative_regulation NFKB1 IL1B 19748795 2153109 ZD 7155 also reduced the mRNA expression of TNF-alpha and , *inhibited* the activation of [NF-kappaB] and AP-1 , and improved lung histopathology . Negative_regulation NFKB1 IL1B 20039418 2192707 Fasudil inhibited induced activation of NF-kappaB independent of the inhibition of IkappaBalpha degradation and nuclear translocation of NF-kappaB , and *inhibited* IL-1beta induced DNA binding of [NF-kappaB] . Negative_regulation NFKB1 IL1B 9510209 491893 C3 transferase exoenzyme , an inhibitor of Rho , abolished BK-induced [NF-kappaB] activation at 10 microg/ml and significantly *inhibited* BK-stimulated synthesis at 5 microg/ml . Negative_regulation NFKB1 IL1RL1 7629057 316539 Moreover , expression of the membrane bound protein in transiently transfected Jurkat cells did not *result* in activation of the transcription factor [NF-kappa B] following IL-1 beta treatment . Negative_regulation NFKB1 ITGB2 14613935 1187967 Co-stimulating and CD11b with activating antibodies *resulted* in [NF-kappaB] activation by GM-CSF and IL-8 in suspended cells . Negative_regulation NFKB1 JAG1 20052673 2211721 Consistent with these results , we found that the down-regulation of Notch-1 or *led* to decreased expression and the activity of [NF-kappaB] downstream genes such as MMP-9 , VEGF , and uPA , contributing to the inhibition of cell migration and invasion . Negative_regulation NFKB1 LBP 15618154 1357612 Here , we report that human high-dose ( hd-LBP ) suppresses binding of both R-type and S-type LPS to CD14 and *inhibits* LPS induced nuclear translocation of [NF-kappaB] , although cellular uptake of R-type LPS was found to be increased by hd-LBP . Negative_regulation NFKB1 MAP2K6 10428782 633239 Cell stress and mediated p38 MAP kinase activation *inhibit* tumor necrosis factor induced IkappaB phosphorylation and [NF-kappaB] activation . Negative_regulation NFKB1 MAP2K6 10878013 722421 We found that a constitutive active -- > ERK pathway *inhibited* [NF-kappaB-driven] transcription . Negative_regulation NFKB1 MAP2K6 11322796 807200 A inhibitor , PD98059 *enhances* IL-1 induced [NF-kappaB] activation by the enhanced and sustained degradation of IkappaBalpha . Negative_regulation NFKB1 MAP2K6 11885780 894068 The *activations* of CREB and [NF-kappaB] were blocked by inhibitors of either p38 ( SB-203580 ) or ( PD-098059 ) , suggesting that they were events downstream of MAK kinase . Negative_regulation NFKB1 MAP2K6 15688034 1376180 Inhibitors of phosphatidylinositol-3'-kinase and Src family kinases significantly inhibited HGF/SF mediated activation of NF-kappaB , while inhibitors of , protein kinase C , and p70 S6 kinase *had* a modest effect or no effect on [NF-kappaB] activity . Negative_regulation NFKB1 MAP2K6 16498455 1624265 TAK1-DN , , and SB203580 , but not MKK3-DN , also *suppressed* RANKL stimulation of [NF-kappaB] transcription activity in a manner dependent on p65 phosphorylation on Ser-536 . Negative_regulation NFKB1 MAP2K6 18176092 1883425 LTD ( 4 ) -induced MUC2 gene transcriptional activity was also suppressed by a G-protein *inhibitor* ( pertussis toxin ) , a protein kinase C ( PKC ) inhibitor ( bisindolylmaleimide ) , a mitogen activated protein/extracellular signal regulated kinase kinase ( ) inhibitor ( PD98059 ) , an extracellular signal regulated kinase-2 ( ERK-2 ) inhibitor ( AG126 ) and a [nuclear factor kappaB (NF-kappaB)] inhibitor . Negative_regulation NFKB1 MAP2K6 19823174 2187306 Sulfur dioxide donor significantly downregulated Raf-1 , ( MEK-1 ) and p-ERK/ERK , and *inhibited* pulmonary vascular smooth muscle cell proliferation , collagen remodeling and pulmonary vascular endothelial cell [nuclear factor-kappaB (NF-kappaB)] , and intercellular adhesion molecule 1 ( ICAM-1 ) expressions . Negative_regulation NFKB1 MAP2K6 20403072 2282180 inhibition also *induced* I-kappaB phosphorylation and enhanced [nuclear factor (NF)-kappaB/DNA] binding activity , leading to expression of cellular inhibitors of apoptosis protein 2 ( c-IAP2 ) , a known nuclear factor-kappaB (NF-kappaB) regulated endogenous anti-apoptotic molecule . Negative_regulation NFKB1 MAP2K6 9446561 483510 Inhibition of LPS mediated as well as LPS and ceramide mediated induction of iNOS and *activation* of [NF-kappaB] by PD98059 , a specific inhibitor of activation of mitogen activated protein (MAP) kinase kinase ( ) , and FPT inhibitor II , a selective inhibitor of Ras farnesyl protein transferase , indicate that the Ras-MAP kinase pathway is involved in LPS-ceramide induced activation of NF-kappaB and induction of iNOS , and that ceramide mediated signaling events probably converge into the LPS modulated MAP kinase signaling pathway resulting in greater activation of NF-kappaB and iNOS induction . Negative_regulation NFKB1 MMP7 17115023 1677213 We found statistically significant correlations between metastatic tumor spread and overexpression of , MMP10/2 , tissue *inhibitor* of metalloproteinase 3 , vascular endothelial growth factor ( VEGF ) , P38 , stromal [NF-kappaB] , and synaptophysin . Negative_regulation NFKB1 NEDD9 7925300 273472 As an in vitro model we show that phosphorylation of *impedes* its ability to interact with [NF-kappa B] , as has been shown before for I kappa B alpha . Negative_regulation NFKB1 NEDD9 9529315 496602 Loss of also *led* to enhanced constitutive p50 homodimer and inducible [NF-kappaB] activities in unstimulated and stimulated cells , respectively . Negative_regulation NFKB1 NES 17603937 1765205 Results showed that *inhibited* [NF-kappaB] activation and nuclear translocation . Negative_regulation NFKB1 PLAT 17717150 1801448 In conclusion , our results demonstrate that after MCAO the interaction between and LRP *results* in [NF-kappaB] activation in astrocytes and induction of inducible nitric-oxide synthase expression in the ischemic tissue , suggesting a cytokine-like plasminogen independent role for tPA during cerebral ischemia . Negative_regulation NFKB1 PLAU 12679464 1077193 and matrix metalloproteinase-9 and enzyme activity and *suppressed* [NF-kappaB] DNA binding activity ( by ANOVA , P < 0.05 ) . Negative_regulation NFKB1 PTGER2 20516073 2295202 Shear induced interleukin-6 synthesis in chondrocytes : *roles* of and EP3 in cAMP/protein kinase A- and PI3-K/Akt dependent [NF-kappaB] activation . Negative_regulation NFKB1 RCAN1 16627481 1583050 Together , these findings suggest that thrombin mediated activation of endothelial cells involves an interplay between NFAT and [NF-kappaB] signaling pathways and their negative feedback *inhibitors* , and I-kappaB , respectively . Negative_regulation NFKB1 RCAN1 17062574 1654644 To elucidate the molecular basis of these anti-inflammatory effects , we analyzed the *role* of in the regulation of [NF-kappaB] transactivation using glioblastoma cells stably transfected with DSCR1 .4 or its truncation mutants ( DSCR1.4- ( 1-133 ) and DSCR1 .4- ( 134-197 ) ) . Negative_regulation NFKB1 S100B 20069545 2201280 Conversely , silencing expression in myoblast cell lines by RNA interference *resulted* in reduced [NF-kappaB] activity and enhanced MyoD , myogenin and MyHC expression and myotube formation . Negative_regulation NFKB1 TGM2 16720350 1565293 Previously we showed that the overexpression of *resulted* in activation of [NF-kappaB] through polymerization of I-kappaBalpha . Negative_regulation NFKB1 TGM2 18923241 1977476 The objective of the present study was to investigate the expression of in the human atherosclerotic human coronary artery , and the possible *roles* of TGase 2 in [NF-kappaB] activation . Negative_regulation NFKB1 TLR7 17296788 1698879 We found that oxidized low-density lipoprotein ( oxLDL ) was the key active component responsible for this effect , as it could directly uncouple mediated signaling on CD8alpha ( - ) myeloid DCs and *inhibit* [NF-kappaB] nuclear translocation . Negative_regulation NFKB1 TLR7 18617174 2019951 activation *results* in nuclear translocation of the transcription factor [Nuclear Factor-kappa B (NF-kappaB)] that controls the transcription of many inflammatory genes . Negative_regulation NFKB1 TLR7 20308556 2238088 Using HEK293 cells transfected with murine TLR7 or TLR8 and a NF-kappaB luciferase reporter , we demonstrated that stimulation of TLR8- , but not , transfected cells with either VV or VV DNA *resulted* in substantial [NF-kappaB] activation , and that siRNA mediated knockdown of TLR8 expression in pDCs led to a complete ablation of VV-induced type I IFN production . Negative_regulation NFKB1 TNF 10085086 599357 Expression of the mutant NFkappaB completely inhibited [NFkappaB] DNA binding activity and *inhibited* both induced up-regulation of Bcl-2 and Bcl-x expression and neuroprotective effect . Negative_regulation NFKB1 TNF 10414954 631095 receptor activation *results* in activation of the transcription factor [nuclear factor kappaB (NF-kappaB)] , which may serve an antiapoptotic role via the induction of target genes manganese superoxide dismutase ( MnSOD ) and/or calbindin . Negative_regulation NFKB1 TNF 10416612 631438 In UM-SCC-9 cells that stably expressed IkappaBalphaM , inhibition of constitutive and *induced* [NF-kappaB] activation , and production of all four cytokines was observed . Negative_regulation NFKB1 TNF 10795524 689675 Furthermore , neutralisation of residual activity or *inhibition* of [NF-kappaB] activation largely restored the inhibitory effect of IL-4 . Negative_regulation NFKB1 TNF 10799332 691168 Inhibition of [NF-kappaB] in the *presence* of is supposed to be a promising cancer therapeutic approach , since it disrupts the protective mechanism of NF-kappaB activated by TNF . Negative_regulation NFKB1 TNF 10820260 694380 Vesnarinone also blocked [NF-kappa B] activation induced by several other inflammatory agents , *inhibited* the induced activation of transcription factor AP-1 , and suppressed the TNF induced activation of c-Jun N-terminal kinase and mitogen activated protein kinase kinase . Negative_regulation NFKB1 TNF 10959811 726328 Pretreatment of rats with DDB prevented LPS induced hepatic I-kappaBalpha degradation and the resultant [NF-kappaB] activation , and *inhibited* the LPS induced plasma TNF-alpha protein and hepatic mRNA expression in a dose dependent manner . Negative_regulation NFKB1 TNF 10993753 733449 Stimulation of myocytes with *resulted* in a 12.1-fold increase ( P < 0.01 ) in [NF-kappa B-dependent] gene transcription and DNA binding compared with controls . Negative_regulation NFKB1 TNF 11198351 779647 Stimulation of control cells with *resulted* in reactive oxygen species ( ROS ) generation and activation of [NF-kappaB] binding to the ICAM-1 promoter and ICAM-1 transcription . Negative_regulation NFKB1 TNF 11274209 819035 However , the signal transduction pathways regulating [NF-kappaB] activation in human neutrophils in *response* to stimulation with are undefined . Negative_regulation NFKB1 TNF 11289659 800575 GSNO ( 500 microM ) decreased induced NFkappaB activity ( p < 0.05 ) and *inhibited* [NFkappaB] activity whether given prior to or during TNFalpha exposure . Negative_regulation NFKB1 TNF 11382928 820951 However , in transformed MEC , [NFkappaB] binding was initially undetectable but then increased in *response* to . Negative_regulation NFKB1 TNF 11445585 860027 Atypical lambda/iota PKC conveys 5-lipoxygenase/leukotriene B4-mediated cross-talk between phospholipase A2s regulating [NF-kappa B] activation in *response* to and interleukin-1beta . Negative_regulation NFKB1 TNF 11445585 860059 Furthermore , lambda/iotaPKC and cPLA(2) phosphorylation was attenuated by phosphatidyinositol 3-kinase ( PI3-kinase ) inhibitors , which also reduced [NF-kappaB] activation in *response* to and IL-1beta , indicating a role for PI3-kinase in these processes in human keratinocytes . Negative_regulation NFKB1 TNF 11479295 860528 In contrast , *induced* IKK activity rapidly and transiently resulting in IkappaBalpha degradation and [NF-kappaB] activation . Negative_regulation NFKB1 TNF 11689467 876278 Furthermore , LA dose-dependently inhibited *induced* IkappaB kinase activation , subsequent degradation of IkappaB , the cytoplasmic [NF-kappaB] inhibitor , and nuclear translocation of NF-kappaB . Negative_regulation NFKB1 TNF 11752021 898652 Electrophoretic mobility shift assays demonstrated that NO donors repressed IP-10 gene transcription *induced* by IFN-gamma plus through the inhibition of [NF-kappaB] activation . Negative_regulation NFKB1 TNF 11820362 908779 Transfection of NFkappaB and C/EBPbeta-sensitive reporter promoter constructs demonstrated that [NFkappaB] activity was enhanced and that constitutive C/EBPbeta was *inhibited* by , with both effects being p38 MAPK dependent . Negative_regulation NFKB1 TNF 11837326 911506 This was further reinforced by the demonstration that herbimycin A , a tyrosine kinase inhibitor , *prevented* [NF-kappaB] activation by photosensitization but not by , a cytokine known to activate NF-kappaB through an IKK dependent mechanism . Negative_regulation NFKB1 TNF 11991979 938617 Inhibition of alpha *induced* [NF-kappa B] activation by the adenovirus E3-10.4/14.5K complex . Negative_regulation NFKB1 TNF 12175093 974553 Ketamine significantly reduced the LPS induced [NFkappaB] activation and *inhibited* production in a dose dependent manner . Negative_regulation NFKB1 TNF 12356823 994048 Exposure to NaOCl ( 0.75 mM ) for 10 minutes caused suppression of *induced* increases in IL-1alpha mRNA and protein , declines in [NFkappaB] nuclear transfer , and a modification of IkappaBalpha , based on a bandshift detected by Western blot analysis . Negative_regulation NFKB1 TNF 12485424 1024923 Inhibition of *stimulated* [NFkappaB/p65] in human keratinocytes by alpha-melanocyte stimulating hormone and adrenocorticotropic hormone peptides . Negative_regulation NFKB1 TNF 12517920 1071011 Inhibition of alpha *mediated* [NFkappaB] activation and leukocyte adhesion , with enhanced endothelial apoptosis , by G protein linked receptor ( TP ) ligands . Negative_regulation NFKB1 TNF 12709429 1112678 The *role* of receptor associated factor ( TRAF)-1 in [NF-kappaB] activation by various members of the TNF receptor family is not well understood , and conflicting data have been published . Negative_regulation NFKB1 TNF 12871593 1114136 *Activation* of [NF-kappaB] as well as C/EBPbeta by p40 and inhibition of p40 induced expression of by Deltap65 , a dominant negative mutant of p65 , and DeltaC/EBPbeta , a dominant negative mutant of C/EBPbeta , suggests that p40 induces the expression of TNF-alpha through the activation of NF-kappaB and C/EBPbeta . Negative_regulation NFKB1 TNF 14503852 1144638 Astaxanthin also suppressed the serum levels of NO , PGE2 , , and IL-1beta in LPS administrated mice , and *inhibited* [NF-kappaB] activation as well as iNOS promoter activity in RAW264.7 cells stimulated with LPS . Negative_regulation NFKB1 TNF 14572618 1155838 In contrast , either the proteasome inhibitor carbobenzoxy-L-leucy-L-leucy-L-leucinal ( MG 132 ) or the IkappaBalpha inhibitor BAY 11-7082 ablated induced ICAM-1 gene expression and MG132 *inhibited* TNFalpha induced [NFkappaB] complexes . Negative_regulation NFKB1 TNF 14584760 1159103 Treatment of rats with HES ( 3.75 and 7.5 ml/kg ) prevented LPS induced [NF-kappaB] activation , and *inhibited* , in a dose related manner , LPS induced and CINC expression . Negative_regulation NFKB1 TNF 14607933 1162139 TNF-alpha treatment induces a more robust activation of [NF-kappaB] in STAT-1alpha-deficient cells , and restoration of STAT-1alpha *inhibits* dependent NF-kappaB activation . Negative_regulation NFKB1 TNF 14766965 1212041 Furthermore , the activation of [NF-kappaB] by TAB3 was *blocked* by the NF-kappaB inhibitor , SN50 , and by expression of dominant negative forms of alpha associated factor 6 and transforming growth factor beta activated kinase . Negative_regulation NFKB1 TNF 15068390 1184285 Removal of after stimulation *resulted* in a faster decrease in both [NF-kappa B] DNA binding activity and I kappa B-alpha mRNA levels . Negative_regulation NFKB1 TNF 15322736 1287027 In vivo treatment with cloricromene ( 2 mg/kg/i.v. ) 30 min before lipopolysaccharide administration reversed the LPS induced loss in tone of the aortic rings , improved their reactivity to phenylephrine , decreased both nitric oxide ( NO ) and serum levels by inhibiting LPS induced inducible NO synthase and TNF-alpha mRNA expression , and interestingly *inhibited* LPS induced [NF-kappaB] activation . Negative_regulation NFKB1 TNF 15538942 1336712 Rat seminiferous tubule segments were cultured in the presence and absence of , infliximab and SN50 , a [NF-kappa B] *inhibitor* . Negative_regulation NFKB1 TNF 15653317 1364398 Recently , the underlying mechanism by which A20 downregulates [NF-kappaB] activation in *response* to the pro-inflammatory cytokine has been described . Negative_regulation NFKB1 TNF 15659838 1350240 p7F also suppressed the serum level of in mice treated with collagen and *inhibited* [nuclear factor-kappaB (NF-kappaB)] activation as well as NF-kappaB promoter activity in RAW 264.7 cells stimulated with LPS . Negative_regulation NFKB1 TNF 15660126 1369506 Herein , we demonstrate that both mediated repression and EGF mediated activation of EAAT2 expression *require* [NF-kappaB] . Negative_regulation NFKB1 TNF 15760549 1383246 Glycine could efficiently protect rat liver grafts from ischemia-reperfusion injury by repressing the expression of CD14 and [NF-kappa B] binding activity in Kupffer cells and *inhibiting* the productions of and IL-1 . Negative_regulation NFKB1 TNF 15833158 1397582 In IP , mutations in NEMO lead to the complete loss of [NF-kB] activation creating a susceptibility to cellular apoptosis in *response* to . Negative_regulation NFKB1 TNF 15857826 1418933 On the other hand , [NFkappaB-p65] transcriptional activity was substantially *reduced* by , which targeted a trans-activation domain at the very C terminus of the p65 molecule . Negative_regulation NFKB1 TNF 15870274 1404477 A prominent function of p62 is the regulation of [NF-kappaB] activation in *response* to interleukin-1 (IL-1) and signaling through the formation of an aPKC/p62/TRAF6 multiprotein signaling complex . Negative_regulation NFKB1 TNF 16020286 1432114 Presence of the NF-kappaB inhibitor kamebakaurin in culture medium blocked P. aeruginosa induced [NF-kappaB] activation and *inhibited* IL-6 , IL-8 , and expression and secretion . Negative_regulation NFKB1 TNF 16078585 1442533 The results indicated that thalidomide treatment significantly reduced colonic inflammation , suppressed [NF-kappaB] activation , enhanced TNF-alpha mRNA degradation , *inhibited* the synthesis of the , IEN-gamma and increased the production of IL-4 . Negative_regulation NFKB1 TNF 16105982 1482165 Treatment with arsenic trioxide ( ATO ; 2-200 microM ) inhibited [NF-kappaB] activity in normal marrow , primary MDS , and ML1 cells , even in the *presence* of exogenous ( 20 ng/mL ) , and down-regulated NF-kappaB dependent antiapoptotic proteins , B-cell leukemia XL (Bcl-XL) , Bcl-2 , X-linked inhibitor of apoptosis (XIAP) , and Fas associated death domain (FADD)-like interleukin-1beta converting enzyme ( FLICE ) inhibitory protein ( FLIP ) , leading to apoptosis . Negative_regulation NFKB1 TNF 16110831 1445341 DATS could downregulate production and *inhibit* [NF-kappaB] activation in lamina propria mononuclear cells of inflammed mucosa , without any effect on the viability of colonic tissue cells . Negative_regulation NFKB1 TNF 16303143 1546886 Further , stimulation induced the degradation of IkappaB-alpha and *resulted* in the transcriptional activation of [NF-kappaB] . Negative_regulation NFKB1 TNF 16536903 1536570 Addition of meloxicam into synovial fibroblast cultures inhibited dose-dependently mRNA expression for MMPs and TIMPs , which were *increased* by stimulation , through the suppression of [NF-kappaB] and AP-1 activation . Negative_regulation NFKB1 TNF 16770837 1682199 ADMA ( 30 microM ) significantly increased the activity of NF-kappaB and elevated the levels of ICAM-1 and , and pre-treatment with rosiglitazone ( 10 or 30 microM ) markedly *inhibited* the increased activity of [NF-kappaB] and reduced the elevated levels of TNF-alpha and ICAM-1 induced by ADMA in cultured endothelial cells . Negative_regulation NFKB1 TNF 16774932 1672075 PMA selectively causes the degradation of IkappaB kinases ( IKKs ) including IKK-gamma and IKK-beta , and subsequent inhibition of *induced* IKK and [NF-kappaB] activation in human colon cancer cell line HCT-116 , but not in other gastrointestinal tract cells . Negative_regulation NFKB1 TNF 16953224 1700206 The expression of constitutively active NF-kappaB in HNSCC is mediated through the tumor necrosis factor (TNF) signaling pathway , as [NF-kappaB] reporter activity was *inhibited* by receptor associated death domain ( TRADD ) , DN-TNF receptor associated factor (TRAF)2 , DN-receptor interacting protein ( RIP ) , DN-transforming growth factor-beta activated kinase 1 ( TAK1 ) , DN-kappa-Ras , DN-AKT and DN-IKK but not by DN-TRAF5 or DN-TRAF6 . Negative_regulation NFKB1 TNF 16965747 1616053 QGHXR can protect liver cells by down regulating the expressions of CD14 , TLR(4) and [NF-kappaB] and *inhibiting* expression . Negative_regulation NFKB1 TNF 16987412 1628283 mediated activation of IKK-beta *resulted* in activation of [NF-kappaB] and was followed by up-regulation of the bona-fide target gene cyclin D1 . Negative_regulation NFKB1 TNF 17115116 1709116 Resveratrol , a polyphenolic , natural phytoalexin found with particularly high levels in grape skin and red wine is potent and specific inhibitor of and IL-1beta *induced* [NF-kappaB] activation . Negative_regulation NFKB1 TNF 17253597 1710338 Co-incubation of MPM cells with and pyrrolidine dithiocarbamate ( PDTC ) , an [NF-kappaB] *inhibitor* , prevented TNF mediated up-regulation of IAP gene expression levels . Negative_regulation NFKB1 TNF 17851586 1858277 CYLD protein harboring this missense mutation had a significant reduced ability to *inhibit* TNF receptor associated factor (TRAF)2- and TRAF6 mediated [NF-kappaB] activation , induced JNK signaling , and to deubiquitinate TRAF2 . Negative_regulation NFKB1 TNF 17931811 1819691 In lipopolysaccharide (LPS) stimulated RAW264.7 cells , HMCO5 inhibited [NF-kappaB] activation as well as iNOS promoter activity , *inhibited* the secretion of and IL-1beta , and directly inhibited the intracellular accumulation of reactive oxygen species . Negative_regulation NFKB1 TNF 17934460 1819717 Using genetic and molecular approaches , we show that Birc2 positively regulates the formation of the receptor complex I in endothelial cells , thereby *promoting* [NF-kappaB] activation and maintaining vessel integrity and stabilization . Negative_regulation NFKB1 TNF 17953529 1814633 The mice with colitis treated by AN showed less tissue damage , less MPO activity , less production in colon , and *inhibited* [NF-kappaB] activation in LPMC , compared with those mice with colitis untreated , whereas the mice with colitis treated by CHD showed the worst tissue damage , the highest MPO activity , the highest TNF-alpha level , and enlarged NF-kappaB activation in LPMC . Negative_regulation NFKB1 TNF 17959522 1814946 Compared to that of the control group , activity of pulmonary NF-kappaB in burned rats was markedly increased within 1 PBH and kept increasing till 24 h. Expressions of pulmonary and IL-8 mRNAs increased gradually , reaching the peak level at 6 PBH , and PDTC could effectively *inhibit* pulmonary [NF-kappaB] activation and expression of the pulmonary cytokines induced by the burn injury . Negative_regulation NFKB1 TNF 17975552 1850140 We show in this study that R-Roscovitine can downregulate [nuclear factor-kappa B (NF-kappaB)] activation in *response* to and interleukin 1 . Negative_regulation NFKB1 TNF 18040799 1669139 *Activation* of [NF-kappaB] by TNF-alpha and inhibition of induced BDNF expression by Deltap65 ( a dominant negative mutant ) and NEMO binding domain peptide ( an inhibitor of NF-kappaB ) suggests that TNF-alpha induces BDNF expression through the activation of NF-kappaB . Negative_regulation NFKB1 TNF 18056399 1833527 Notably , stimulation of HEK293T cells with or overexpression of the p65 subunit of NF-kappaB *resulted* in up-regulation of NLRP2 and the formation of [NF-kappaB-NLRP2] promoter complexes . Negative_regulation NFKB1 TNF 18064709 1937867 It is also suggested that TNF-alpha activates [NF-kappaB] and increases transgene expression by pDNA having many NF-kappaB binding sites , but also *reduces* transgene expression at later time periods , leading to short-term transgene expression . Negative_regulation NFKB1 TNF 18178551 1875720 Thus we conclude that endogenous Cezanne can attenuate [NF-kappaB] activation and the induction of pro-inflammatory transcripts in *response* to signaling . Negative_regulation NFKB1 TNF 18266467 1896056 Here we demonstrate that ectopic expression of B14 inhibited [NF-kappaB] activation in *response* to , IL-1beta , poly ( I:C ) , and PMA . Negative_regulation NFKB1 TNF 18385389 1925576 MT downregulated the mRNA level , and PDTC *inhibited* the increases in both [NF-kappaB] translocation and TNF-alpha mRNA . Negative_regulation NFKB1 TNF 18567808 1929753 As examined by DNA binding , we found that TQ suppressed induced NF-kappa B activation in a dose- and time dependent manner and *inhibited* [NF-kappaB] activation induced by various carcinogens and inflammatory stimuli . Negative_regulation NFKB1 TNF 18779659 1963172 The stimulation of lymphoid cells with , IL-1beta , and LPS *resulted* in significant ROS production and [NF-kappaB] activation . Negative_regulation NFKB1 TNF 19043589 1998947 However , exposure of macrophages and human monocytes to FHA for two hours or more resulted in the accumulation of cytosolic IkappaB alpha , and the failure of to *activate* [NF-kappaB] . Negative_regulation NFKB1 TNF 19063961 2030173 [NF-kappaB] activation products such as Bcl-2 , Bcl-X ( L ) , cFLIP ( S ) , cFLIP ( L ) , and Mn-SOD were *reduced* by plus PY and restored by 1400W or NAC . Negative_regulation NFKB1 TNF 19086324 2000282 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 MAPK and [NF-kappaB] activities , and then overexpression , thus alleviating the inflammatory reaction . Negative_regulation NFKB1 TNF 19182383 2033248 Mangiferin also reduced acetylcholine and levels induced by scopolamine in mice brain ( p < 0.05 ) and *inhibited* [nuclear factor (NF)-kappaB] activation in scopolamine or TNF-alpha stimulated BV-2 microglial cells . Negative_regulation NFKB1 TNF 19284955 2046497 ( 1 microg/L ) strongly induced the expression of NF-kappaB by approximately 1.76-fold compared with the control in the nuclei of A549 cells , and the induced [NF-kappaB] expression was significantly *suppressed* by addition of Feiyanning ( P < 0.01 ) . Negative_regulation NFKB1 TNF 19287455 2055881 It has been shown that stimulation *leads* to degradation of TNF receptor associated factor-2 (TRAF2) and inhibition of TNFR1 induced activation of [NFkappaB] and JNK . Negative_regulation NFKB1 TNF 19405981 2082343 GSK-3 inhibition reduced both basal and *induced* [NF-kappaB] luciferase activity . Negative_regulation NFKB1 TNF 19409903 2082514 Although TNFalpha induced receptor interacting protein 1 ubiquitination is indeed impaired in T2/5 DKO cells , stimulation further *increases* IKK activity in these cells , resulting in significantly elevated expression of [NF-kappaB] target genes to a level higher than that in wild-type cells . Negative_regulation NFKB1 TNF 19420112 2106621 However , the broad-spectrum caspase inhibitor Boc-d-fmk reduced [NF-kB] activation as assessed by gel shift assay , reduced phosphorylation of subunit IkappaBalpha , and significantly *inhibited* induced expression of ICAM-1 and VCAM-1 as assessed by both real-time PCR and flow cytometry . Negative_regulation NFKB1 TNF 19616538 2124179 Ghrelin also significantly suppressed interleukin-1beta , , and endothelin-l mRNA expression , and *inhibited* [NF-kappaB] activation . Negative_regulation NFKB1 TNF 19748795 2153108 ZD 7155 also reduced the mRNA expression of and IL-1 beta , *inhibited* the activation of [NF-kappaB] and AP-1 , and improved lung histopathology . Negative_regulation NFKB1 TNF 20030669 2287269 In the ARDS model , vitamin K3 also suppressed the LPS induced increase in the serum level and *inhibited* the LPS evoked nuclear translocation of [NF-kappaB] in lung tissue . Negative_regulation NFKB1 TNF 20451670 2288434 Meanwhile , HES could significantly reduce , IL-6 , and ICAM-1 mRNA , *inhibit* [NF-kappaB] activation , and down-regulate TLR2 and TLR4 expression in the brain . Negative_regulation NFKB1 TNF 23066265 2685775 Doxycycline , nonsteroidal anti-inflammatory drugs ( NSAIDs ) , bisphosphonates , nitrous oxide ( NO ) synthase inhibitors , recombinant human interleukin-11 ( rhIL-11 ) , omega-3 fatty acid , mouse anti-human interleukin-6 receptor antibody ( MRA ) , mitogen activated protein kinase (MAPK) inhibitors , [nuclear factor-kappa B (NF-kb)] *inhibitors* , osteoprotegerin , and tumor necrosis factor antagonist ( ) are some of the therapeutic agents that have host modulation properties . Negative_regulation NFKB1 TNF 24331632 2880523 Effects on the *induced* inhibitor of [NF-kB] ( IkBa ) activity ( phosphorylation status ) and its formation of adducts were detected by western blotting and immunoprecipitation . Negative_regulation NFKB1 TNF 7594489 334759 The effect of LPS and is *mediated* by their ability to induce nuclear translocation of the DNA binding heterodimer [NF-kappa B] ( p50/p65 ) , which binds to a specific sequence in the HIV-long terminal repeat . Negative_regulation NFKB1 TNF 7929839 274673 Both PDTC and HMAP attenuated the increase in nuclear [NF-kB] in *response* to either or IgG complexes . Negative_regulation NFKB1 TNF 7929839 274677 Preincubation of cells with 8 br-cAMP , forskolin , or PGE2 attenuated the increase in nuclear [NF-kB] in *response* to , aggregated IgG , or superoxide anion . Negative_regulation NFKB1 TNF 8207202 261382 However , only ( but not IL-2 ) efficiently *recovered* the nuclear [NF-kappa B] levels . Negative_regulation NFKB1 TNF 8334993 223780 We describe here that in porcine aortic endothelial cells , either IL-1 alpha , or LPS *upregulates* an inhibitor of [NF kappa B] which we refer to as ECI-6 . Negative_regulation NFKB1 TNF 8900181 393446 Electrophoretic mobility shift assays with nuclear extracts of A3 cells showed that stimulation with ATRA and for more than 16 h *resulted* in enhanced [NF-kappaB] binding compared to that induced by TNF-alpha alone . Negative_regulation NFKB1 TNF 9003392 404834 Exposure of rat Kupffer cells to a physiologically relevant concentration of lipopolysaccharide ( 10 ng/ml ) activated NF-kappa B within 1 h and induced the release of TNF-alpha over 5 h. Cellular glutathione content remained unchanged after lipopolysaccharide exposure , but both glutathione monoethyl ester and N-acetyl-L-cysteine increased cellular glutathione levels , blocked [NF-kappa B] activation and *inhibited* the release of . Negative_regulation NFKB1 TNF 9438495 474992 also *prevented* [nuclear factor-kappa B (NF-kappa B)] activation , and a good correlation between this inhibition and inhibition of HIV replication was observed . Negative_regulation NFKB1 TNF 9718198 528175 These results suggest that the rapid activation of NF-kappaB by is mainly due to the nuclear translocation of NF-kappaB pre existing in cytosol , and that the subsequent increase in the expression of p50 and p65 may *result* in the persistent activation of [NF-kappaB] during TNF-alpha stimulation . Negative_regulation NFKB1 TNFSF10 10807904 736588 Overexpression of the tumor necrosis factor (TNF) related apoptosis inducing ligand ( ) receptors , TRAIL-R1 and TRAIL-R2 , *induces* apoptosis and activation of [NF-kappaB] in cultured cells . Negative_regulation NFKB1 TNFSF10 16645643 1672028 Both addition of IGFBP-3 protein to cell cultures or enforced expression of IGFBP-3 in the HT29 carcinoma cell line inhibited [nuclear factor kappa B (NF-kappaB)] activation in *response* to the induction of apoptosis by . Negative_regulation NFKBIA ARSA 10593965 572929 Phosphorylation of a glutathione [S-transferase-IkappaBalpha] fusion protein by cellular extracts or immunoprecipitated IKKalpha isolated from cells treated with TNFalpha is *inhibited* by <5-ASA> . Negative_regulation NFKBIA ARSA 10593965 572932 Recombinant IKKalpha and IKKbeta autophosphorylation and their phosphorylation of glutathione [S-transferase-IkappaBalpha] are *inhibited* by <5-ASA> . Negative_regulation NFKBIA ARSA 15763541 1383552 Concomitantly , *inhibited* nuclear factor (NF)-kappaB activity , as well as the phosphorylation and breakdown of the inhibitory protein [IkappaB-alpha] . Negative_regulation NFKBIA ARSA 15763541 1383554 We thus propose that the anti-inflammatory effects of in mast cells are due to suppression of IkappaB kinase activity , thereby *inhibiting* subsequent phosphorylation and degradation of [IkappaB-alpha] , activation of NF-kappaB , and transcription of proinflammatory cytokines . Negative_regulation NFKBIA CAPN8 15202778 1261017 Furthermore , inhibition *increased* [IkB alpha] levels compared to nonactivated controls . Negative_regulation NFKBIA CAPN8 20659425 2305122 Interestingly , the combined inhibition of and the proteasome *resulted* in an increased accumulation of both I-kappaBalpha polymers and [I-kappaBalpha] , concurrent with an inhibition of NF-kappaB activity in MDA-MB-231 cells . Negative_regulation NFKBIA EPHB2 15073167 1257628 However , results of immunoblotting analysis showed that neither cisplatin nor inhibitors *induced* marked [IkappaBalpha] degradation , suggesting that suppression of the MEK/ERK signaling pathway may enhance cisplatin induced NF-kappaB activation via mechanisms other than the conventional pathway . Negative_regulation NFKBIA EPHB2 16242916 1532016 Consistently , inhibition of significantly *increased* IkappaB kinase (IKK) activity , [IkappaBalpha] phosphorylation , and nuclear translocation of NF-kappaB induced by VEGF , whereas overexpression of ERK resulted in the loss of these responses to VEGF . Negative_regulation NFKBIA EPHB2 18648999 2028057 Activation of *resulted* in phosphorylation of [IkappaB-alpha] which lead to its degradation which in turn followed by nuclear translocation of NF-kappaB , which is also supported by the western blot analysis . Negative_regulation NFKBIA EPHB2 20133626 2213446 Degradation of [IkappaB alpha] , which is considered a primary requirement for NEMO mediated immune signaling , occurred normally in response to Toll-like receptor stimulation , yet phosphorylation and NF-kappaB p65 nuclear translocation were severely *impaired* . Negative_regulation NFKBIA FUT4 17410536 1736310 In a time dependent and dose dependent manner , *inhibited* [IkappaBalpha] phosphorylation and NF-kappaB activation , thereby inhibiting the antiapoptotic activity of NF-kappaB . Negative_regulation NFKBIA IL1B 10218970 608583 *caused* a rapid increase in phosphorylated IkappaB-alpha levels and subsequent transient decrease in [IkappaB-alpha] levels , an inhibitor of NF-kappaB , as revealed by Western blot analysis using specific antibodies for phosphorylated and nonphosphorylated IkappaB-alpha . Negative_regulation NFKBIA IL1B 11428868 831563 Stimulation of hRPE with and TNF-alpha *resulted* in degradation of [IkappaB-alpha] , nuclear translocation of NF-kappaB , and prominent increases in p38 and ERK1/2 phosphorylation for as little as 3 min . Negative_regulation NFKBIA IL1B 14622131 1168646 Interaction of to its specific receptor interleukin-1 receptor type I (IL-1RI) *leads* to nuclear factor kappa B ( NuFkappaB ) nuclear translocation and a robust transcriptional activation of inhibitor of kappa B alpha ( [IkappaBalpha] ) within the rat brain . Negative_regulation NFKBIA IL1B 15739117 1383025 consistently *increased* islet NFkappaB activity and c-Myc , haeme-oxygenase 1 , inducible nitric oxide synthase (iNOS) , Fas , and inhibitor of NFkappaB alpha ( [IkappaBalpha] ) mRNA levels . Negative_regulation NFKBIA IL1B 16258173 1489909 Stimulation of fibroblast-like synoviocytes with *resulted* in rapid degradation of [IkappaBalpha] , an event that was preceded by IkappaBalpha phosphorylation . Negative_regulation NFKBIA IL1B 19171646 2027683 *induced* the phosphorylation and downregulation of [IkappaB-alpha] as well as the translocation of p65 to the nucleus . Negative_regulation NFKBIA IL1B 20116443 2258837 C4S inhibited the enhanced expression of COX-2 and mPGES1 but had no effect on the *induced* decrease of [I-kappaBalpha] and nuclear translocation of NF-kappaB . Negative_regulation NFKBIA IL1B 9188479 437208 stimulation *caused* transient loss of [IkappaBalpha] and a sustained decrease of IkappaBbeta that correlated with increased and persistent levels of p65/p50 protein and binding activity in the nucleus . Negative_regulation NFKBIA IL1B 9794459 543062 and TNF alpha , but not neutral SMase , *caused* a transient decrease in [IkappaB-alpha] protein levels , whereas IkappaB-beta protein expression was not affected by either agent . Negative_regulation NFKBIA MAP2K6 15073167 1257634 However , results of immunoblotting analysis showed that neither cisplatin nor inhibitors *induced* marked [IkappaBalpha] degradation , suggesting that suppression of the MEK/ERK signaling pathway may enhance cisplatin induced NF-kappaB activation via mechanisms other than the conventional pathway . Negative_regulation NFKBIA TGM2 17108131 1645500 Inhibition of in drug-resistant cells by RNA interference *increased* the levels of [IkappaBalpha] , and this correlated with a shift in the accumulation of NF-kappaB from the nucleus to the cytosol . Negative_regulation NFKBIA TLR7 18523248 1922749 SP-A decreases the phosphorylation of [IkappaBalpha] , a key regulator of NF-kappaB activity , and nuclear translocation of p65 which result in diminished TNF-alpha secretion in *response* to ligands . Negative_regulation NFKBIA TNF 10869349 730084 Persistent signaling in normal human fibroblasts *prevents* the complete resynthesis of [I kappa B-alpha] . Negative_regulation NFKBIA TNF 10959811 726329 Pretreatment of rats with DDB prevented LPS induced hepatic [I-kappaBalpha] degradation and the resultant NF-kappaB activation , and *inhibited* the LPS induced plasma TNF-alpha protein and hepatic mRNA expression in a dose dependent manner . Negative_regulation NFKBIA TNF 11289659 800579 GSNO exposure ( 500 microM ) inhibited [IkappaB alpha] degradation in the *presence* of . Negative_regulation NFKBIA TNF 11319155 806775 treatment *induced* a rapid decrease in the levels of [IkappaB-alpha] . Negative_regulation NFKBIA TNF 11428868 831562 Stimulation of hRPE with IL-1beta and *resulted* in degradation of [IkappaB-alpha] , nuclear translocation of NF-kappaB , and prominent increases in p38 and ERK1/2 phosphorylation for as little as 3 min . Negative_regulation NFKBIA TNF 11479295 860532 In contrast , *induced* IKK activity rapidly and transiently resulting in [IkappaBalpha] degradation and NF-kappaB activation . Negative_regulation NFKBIA TNF 11515677 851104 Stimulation with *resulted* in rapid phosphorylation and degradation of [IkappaBalpha] followed by NF-kappaB nuclear translocation . Negative_regulation NFKBIA TNF 11677267 873607 *induces* a down-regulation of [IkappaB-alpha] , -beta and -epsilon both in physiological and in stress , i.e. serum-free , conditions . Negative_regulation NFKBIA TNF 12055237 951768 In addition , we show that *mediated* loss of cytoplasmic [I kappa B alpha] in eosinophils is inhibited by 15dPGJ ( 2 ) in a concentration dependent manner . Negative_regulation NFKBIA TNF 15068390 1184286 Removal of after stimulation *resulted* in a faster decrease in both NF-kappa B DNA binding activity and [I kappa B-alpha] mRNA levels . Negative_regulation NFKBIA TNF 15550448 1367862 In contrast , *resulted* in higher [IkappaB-alpha] kinase activity at 20 min than at 10 min , and similar low IkappaB-alpha at 10 and 20 min . Negative_regulation NFKBIA TNF 16105945 1448386 The synergistic interaction between fXa and was also *involved* in the inhibition of A20 and [IkappaBalpha] expression in the IkappaB kinase-NF-kappaB pathway . Negative_regulation NFKBIA TNF 16525884 1574377 Furthermore , Gyp-XLIX restored the LPS- and *induced* decrease in cytosolic [I-kappaBalpha] protein expression and inhibited the translocation of NF-kappaB ( p65 ) to the nucleus in THP-1 monocyte and HUVEC cells . Negative_regulation NFKBIA TNF 16891465 1597085 We found that treatment of cancer cells with AGRO100 inhibits IKK activity and reduces phosphorylation of [IkappaBalpha] in *response* to stimulation . Negative_regulation NFKBIA TNF 18235000 1864343 *induced* the phosphorylation and downregulation of [IkappaB-alpha] and the translocation of the p65 subunit of NF-kappaB to the nucleus . Negative_regulation NFKBIA TNF 18559343 1952552 OxPAPC *inhibited* production , [IkappaBalpha] degradation , p38 MAPK phosphorylation , and NF-kappaB dependent reporter activation induced by stimulants of TLR2 and TLR4 ( Pam3CSK4 and LPS ) but not by stimulants of other TLRs ( poly ( I.C ) , flagellin , loxoribine , single stranded RNA , or CpG DNA ) in macrophages and HEK-293 cells transfected with respective TLRs and significantly reduced inflammatory responses in mice injected subcutaneously or intraperitoneally with Pam3CSK4 . Negative_regulation NFKBIA TNF 19420112 2106625 However , the broad-spectrum caspase inhibitor Boc-d-fmk reduced NF-kB activation as assessed by gel shift assay , reduced phosphorylation of subunit [IkappaBalpha] , and significantly *inhibited* induced expression of ICAM-1 and VCAM-1 as assessed by both real-time PCR and flow cytometry . Negative_regulation NFKBIA TNF 19656901 2143593 LPS-tolerant cells showed increased expression of negative regulators Toll interacting protein (Tollip) , suppressor of cytokine signaling (SOCS)-1 , IL-1R associated kinase-M , and SHIP-1 , which correlated with reduced p38 phosphorylation , [IkappaB-alpha] degradation , and *inhibited* expression of , IL-6 , and IL-8 . Negative_regulation NFKBIA TNF 8497253 220739 and interleukin-1 *lead* to phosphorylation and loss of [I kappa B alpha] : a mechanism for NF-kappa B activation . Negative_regulation NFKBIA TNF 8977194 408703 A similar lack of [IkappaB alpha] degradation in HT-29 cells *followed* and bacterial polymer stimulation . Negative_regulation NFKBIA TNF 9743602 532607 In contrast , rapidly induced IkappaBalpha degradation within 5 min and IkappaBbeta degradation within 15 min. Cycloheximide did not *prevent* LPS induced [IkappaBalpha] degradation , indicating that newly synthesized proteins induced by LPS were not involved in LPS stimulated IkappaBalpha degradation . Negative_regulation NFKBIA TNF 9794459 543061 IL-1beta and , but not neutral SMase , *caused* a transient decrease in [IkappaB-alpha] protein levels , whereas IkappaB-beta protein expression was not affected by either agent . Negative_regulation NFKBIB TNF 8663191 368406 *causes* a rapid but partial ( 50 % ) reduction in [IkappaB-beta] , which does not recover by 22 h ; IL-1 and PMA cause slower and less sustained reductions in IkappaB-beta . Negative_regulation NFKBIZ IFI27 17702989 1788771 Overexpression of *enhanced* the LPS induced [IkappaB-zeta] , IL-12p40 and NF-kappaB promoter activities , while anti-sense ( AS ) RNA against Ifi202 strongly suppressed them in a monocytic cell line , RAW 264.7 . Negative_regulation NFKBIZ IL1B 12831461 1105526 stimulation also *results* in the strong induction of [IkappaB-zeta] , but tumor necrosis factor-alpha does not . Negative_regulation NGF IL1B 16884695 1638852 Whereas histamine and *cause* additive stimulatory effect on [NGF] secretion , interaction between histamine and interleukin-6 causes a long-term synergism . Negative_regulation NGF IL1B 17121704 1652221 The HHKs component in the artificial nerve bridge underwent degradation in the sciatic nerve defect after 3 to 4 weeks , and activation *resulted* in enhanced [NGF] expression in the SCs . Negative_regulation NGF IL1B 8554509 339994 In contrast , preincubation with PDGF-BB drastically reduces NGF gene expression and [NGF] protein synthesis in *response* to stimulation . Negative_regulation NGF IL1B 9833249 552012 *Role* of and TNF-alpha in the regulation of [NGF] in experimentally induced arthritis in mice . Negative_regulation NGF MAP2K6 14580320 1156816 Prooxidant effects of [NGF] withdrawal and *inhibition* in sympathetic neurons . Negative_regulation NGF MAP2K6 14580320 1156830 It has been reported that [NGF] suppresses increased ROS production by the mitochondria in these cells through a mitogen activated protein kinase kinase ( MEK ) /mitogen activated protein (MAP) kinase pathway because NGF withdrawal inactivates this pathway and the inhibitor , PD98059 , *increases* ROS in the presence of NGF . Negative_regulation NGF NGFR 7938014 276166 The low-affinity nerve growth factor receptor (NGFR) *induces* apoptosis in the absence of [nerve growth factor (NGF)] binding but enhances neural survival when bound by NGF . Negative_regulation NGF NGFR 8698038 372878 The *role* of the low affinity ( p75 ( NGFR ) ) in [NGF] mediated signaling is not yet understood . Negative_regulation NGF TNF 14654461 1188359 Moreover , lack of *increased* the expression of [nerve growth factor (NGF)] , but not brain derived neurotrophic factor (BDNF) , following performance of the learning task . Negative_regulation NGF TNF 16956589 1627640 The *role* of and its receptors in the production of [NGF] and GDNF by astrocytes . Negative_regulation NGF TNF 8554509 339993 In contrast , preincubation with PDGF-BB drastically reduces [NGF] gene expression and NGF protein synthesis in *response* to IL-1 stimulation . Negative_regulation NGF TNF 9833249 552011 *Role* of IL-1 beta and in the regulation of [NGF] in experimentally induced arthritis in mice . Negative_regulation NGFR MEF2A 9588207 504642 MyoD and *mediate* activation and repression of the [p75NGFR] gene during muscle development . Negative_regulation NGFR NGF 1321963 192098 *induced* loss of cell associated [nerve growth factor receptor] in human melanoma A875 cells . Negative_regulation NGFR NGF 15680337 1366451 The increased level of could *suppress* the increased , AF64A induced [NGF receptor] expression in the medial septal nucleus . Negative_regulation NGFR NGF 2842468 96534 In cultures of high plating density , *increased* the number of [NGF-R] and ChAT positive neurons without affecting the number of AChE positive neurons in these cultures . Negative_regulation NGFR NTRK1 7815475 285259 It was found that NGF internalization was neither prevented by blocking activity using the protein kinase inhibitors methylthioadenosine , staurosporine , and K-252a , nor by *inhibiting* NGF binding to [p75NGFR] with antibodies . Negative_regulation NGFR TBP 19643914 2143191 We found that the high-affinity [nerve growth factor receptor] , TrkA , is *down-regulated* by mutant in cells . Negative_regulation NKX2-1 TNF 10499522 647814 In the present study , we show that *suppresses* DNA binding activity of thyroid transcription factors , Pax-8 and [thyroid transcription factor-1] ( TTF-1 ) , which is , in part , involved in TNF-alpha induced decrease in TG gene expression . Negative_regulation NKX2-1 TNF 21784970 2484594 *inhibited* [TTF-1] but not Sp1 or hepatocyte nuclear factor-3 DNA binding to TTF-1 promoter . Negative_regulation NKX2-1 TNF 21784970 2484596 Transactivation experiments in A549 cells indicated that *inhibited* TTF-1 promoter activation by exogenous Sp1 and [TTF-1] without altering their levels , suggesting inhibition of transcriptional activities of these proteins . Negative_regulation NKX2-1 TNF 21784970 2484598 *inhibition* of [TTF-1] expression was associated with increased threonine , but not serine , phosphorylation of Sp1 . Negative_regulation NKX2-1 TNF 21784970 2484599 Because TTF-1 serves as a positive regulator for surfactant protein gene expression , *inhibition* of [TTF-1] expression could have important implications for the reduction of surfactant protein levels in diseases such as ARDS . Negative_regulation NLRP12 TLR7 19234190 2040176 [NLRP12] transcription is *diminished* by specific stimulation and myeloid cell maturation , consistent with its role as a negative regulator of inflammation . Negative_regulation NLRP2 TNF 18056399 1833526 Notably , stimulation of HEK293T cells with or overexpression of the p65 subunit of NF-kappaB *resulted* in up-regulation of [NLRP2] and the formation of NF-kappaB-NLRP2 promoter complexes . Negative_regulation NM EPHB2 22447027 2582907 The extracellular signal regulated kinase potentiated activity of the G protein coupled receptor kinase GRK2 and *inhibited* [neutrophil migration] , whereas the MAPK p38 acted as a noncanonical GRK that phosphorylated the formyl peptide receptor FPR1 and facilitated neutrophil migration by blocking GRK2 function . Negative_regulation NM IL1B 17874178 1858299 *induced* a dose dependent neutrophil migration to the peritoneal cavity of rats which depends on LTB ( 4 ) , PAF and cytokines , since the animal treatment with inhibitors of these mediators ( MK 886 , PCA 4248 and dexamethasone respectively ) inhibited IL-1beta induced [neutrophil migration] . Negative_regulation NM TCN1 6863645 29057 These results show that does *suppress* [neutrophil migration] in vivo , and they provide support for an anti-inflammatory effect of TCN mediated in part by suppression of neutrophil chemotaxis . Negative_regulation NM TNF 18475491 209551 These data suggest that the defect in [neutrophil migration] during septicaemia or endotoxaemia may be the *result* of the continuous release of IL-8 and into the circulation . Negative_regulation NM TNF 19289819 2055969 IL-17 induced [neutrophil migration] was not affected by COX inhibitors , IL-12 , or IFNgamma but was *inhibited* by MK886 ( a leukotriene synthesis inhibitor ) , , anti-CXCL1 , and anti-CXCL5 antibodies and by repertaxin ( a CXCR1/2 antagonist ) . Negative_regulation NM TNF 2166764 140090 Adenosine and related compounds counteract *inhibition* of [neutrophil migration] : implication of a novel cyclic AMP independent action on the cell surface . Negative_regulation NM TNF 9704061 479316 stimulates neutrophil adherence , degranulation , and superoxide production , but *inhibits* [neutrophil migration] . Negative_regulation NM TNF 9723947 529317 The and MNCF mediated *inhibition* of [neutrophil migration] seems to be indirect , by affecting the mechanisms of adhesion . Negative_regulation NME1 EFNB1 22718351 2691560 As one mechanism , *inhibits* the association of [Nm23-H1] with Tiam1 , which contributes for activation of Rac1 . Negative_regulation NNMT IFNG 20495288 2263637 To clarify the mechanisms by which IFN-gamma increases 1-methylnicotinamide levels in these cells , we measured NNMT activity and the levels of [NNMT] expression , nicotinamide and nicotinamide adenine dinucleotide ( NAD ( + ) ) in the *presence* and absence of . Negative_regulation NOD2 IL1B 16288731 1490602 Human umbilical vascular endothelial cells ( HUVECs ) minimally expressed NOD2 gene , whereas stimulation of HUVEC with bacterial LPS , , or TNF-alpha *resulted* in significant up-regulation of [NOD2] . Negative_regulation NOD2 TNF 12194982 997819 Notably , stimulation of myeloblastic and epithelial cells with bacterial lipopolysaccharide or *resulted* in up-regulation of [Nod2] . Negative_regulation NOD2 TNF 16288731 1490601 Human umbilical vascular endothelial cells ( HUVECs ) minimally expressed NOD2 gene , whereas stimulation of HUVEC with bacterial LPS , IL-1beta , or *resulted* in significant up-regulation of [NOD2] . Negative_regulation NOD2 TNF 21396483 2453295 Artesunate not only inhibited and IL-6 release but also *inhibited* mRNA and protein expressions of TLR2 and [Nod2] , two important receptors , in murine peritoneal macrophages stimulated with heat killed WHO-2 , further demonstrating anti-inflammatory effect of artesunate was related to the inhibition of TLR2- and Nod2 mediated proinflammatory cytokines . Negative_regulation NOD2 TNF 24228579 2868704 Baicalin is able to specifically inhibit the expression of [TLR2/4-NOD2] , *inhibit* the expression of inflammatory factors IL-1beta , IL-6 and , and thereby reducing the injury of the tissue cells during the course of disease . Negative_regulation NOS1 ADRB2 11324456 765130 The organ-bath was used to observe the tension changes in rings of coronary and femoral arteries to different concentrations of isoprenaline ( ISO ) after endothelium removal , [nitric-oxide synthase (NOS)] *inhibition* by L-NMMA and beta 1 and/or antagonization . Negative_regulation NOS1 ARSA 1325882 195305 4. The results suggest that *inhibits* [NOS] but this does not totally account for its effects in reducing NO-mediated relaxations produced by the endothelium dependent vasodilator acetylcholine in rat aortic rings and stimulation of nitrergic nerves in the rat anococcygeus muscle . Negative_regulation NOS1 CAPN8 10835326 699096 *Role* of in hypoxic inhibition of [nitric oxide synthase] activity in pulmonary endothelial cells . Negative_regulation NOS1 CAPN8 16100081 1466387 Involvement of in cigarette smoke *induced* inhibition of lung endothelial [nitric oxide synthase] . Negative_regulation NOS1 EDN2 12193095 981011 *stimulates* an endogenous [nitric oxide synthase] inhibitor , asymmetric dimethylarginine , in experimental heart failure . Negative_regulation NOS1 EDN2 15126084 1244692 In some experiments , the effects of receptor blockade ( with bosentan ) and [nitric oxide synthase (NOS)] *inhibition* ( with L-NAME ) on pravastatin mediated cardioprotection were evaluated . Negative_regulation NOS1 EPHB2 19343212 2057375 At the highest treatment dose of TGF-beta1 , inhibition of phosphorylation *increased* TGF-beta1 induced expression of the anti-parasite effector gene [nitric oxide synthase (NOS)] , suggesting that increasing levels of ERK activation negatively feed back on induced NOS expression . Negative_regulation NOS1 EPHB2 23454199 2771481 In fact , expression increased in brain cortex after remote postconditioning , and its pharmacological inhibition *prevented* both [nNOS] overexpression and remote postconditioning mediated neuroprotection . Negative_regulation NOS1 FOLR1 10997722 734080 also *inhibited* the induction of the calcium independent [NOS] activity and reduced the levels of iNOS protein in rat forebrain slices subjected to OGD . Negative_regulation NOS1 IL1B 11222532 787664 The purpose of these studies was to investigate the *role* of interferon-gamma (IFN-gamma) , tumor necrosis factor-alpha (TNF-alpha) , , and transforming growth factor-beta ( TGF-beta ) in the regulation of inducible [nitric oxide synthase] ( NOS2 ) activity in rabbit corneal cells . Negative_regulation NOS1 IL1B 11330732 808151 To investigate the effect of , granulosa-luteal cells were cultured with various doses of IL-1beta ( 0 , 0.05 , 0.5 , 5 , 50 , 100 ng/ml ) , IL-1beta ( 5 ng/ml ) with NG-nitro-L-arginine-methyl ester ( L-NAME ) , selective *inhibitors* of [NOS] , sodium nitroprusside ( SNP ) , NO donors and Genistain , a tyrosine kinase inhibitor . Negative_regulation NOS1 IL1B 11736735 885815 The intestinal anti-inflammatory effect of morin was accompanied by a significant reduction in colonic leukotriene B4 and levels , improvement in colonic oxidative stress and *inhibition* of colonic [nitric oxide synthase] activity . Negative_regulation NOS1 IL1B 15948176 1434321 In the present report , we examined the role of in neurotoxicity induced by microglial conditioned media , and possible neuroprotective effects of NE. Incubation of cortical neurons with conditioned media ( CM ) obtained from lipopolysaccharide (LPS) treated microglia *induced* [neuronal NOS2] expression and increased neuronal cell death , and these responses were reduced if the neurons were coincubated with interleukin-1 receptor antagonist . Negative_regulation NOS1 IL1B 17923423 1888909 Cartilage explants were subjected to treatment with TNF-alpha ( 100ng/ml ) , ( 10 ng/ml ) and to the [nitric oxide synthase] *inhibitor* , N-methyl-arginine ( L-NMA ; 1.25 mM ) for 26 , 50 or 120 h ( 5 days ) . Negative_regulation NOS1 ITGB2 10880532 709205 IFN-gamma mediated apoptosis was abolished by depleting adherent cells or ( + ) spleen cells or by *inhibiting* [nitric oxide synthase] . Negative_regulation NOS1 MAP2K6 21742048 2490056 However , nicotine treatment failed to enhance ERK1/2 phosphorylation when NPC12 cells were pretreated with several selective *inhibitors* of [NOS] , the nicotinic acetylcholine receptors , L-type voltage dependent Ca ( 2+ ) channels , protein kinase C , Src , epidermal growth factor receptor , and . Negative_regulation NOS1 MAP2K6 22001931 2503123 The neurotoxicity of NaHS was resistant to inhibitors of NMDA receptors , T-type calcium channels and [NOS] , and was *blocked* by inhibitors of , but not JNK , p38 MAP kinase , PKC and Src . Negative_regulation NOS1 PECAM1 15985432 1441183 Tie2 and expression decreased > 80 % after siRNA treatment , and flow stimulated phosphorylation of ERK1/2 , Akt , and endothelial [nitric oxide synthase] was significantly *inhibited* by Tie2 and PECAM1 siRNA . Negative_regulation NOS1 PLAT 17717150 1801459 In conclusion , our results demonstrate that after MCAO the interaction between and LRP *results* in NF-kappaB activation in astrocytes and induction of inducible [nitric-oxide synthase] expression in the ischemic tissue , suggesting a cytokine-like plasminogen independent role for tPA during cerebral ischemia . Negative_regulation NOS1 PPBP 19883643 2197226 Immunoblots of putamen extracts at 3 h of recovery showed that decreased H-I induced recruitment of nNOS in the membrane fraction and *reduced* the association of [nNOS] with NMDA receptor NR2 subunit . Negative_regulation NOS1 PPBP 19883643 2197227 Moreover , *suppressed* [NOS] activity in the membrane fraction and reduced H-I induced nitrative and oxidative damage to proteins and nucleic acids . Negative_regulation NOS1 SYNC 12467731 1032214 We speculate that the loss of alpha-dystrobrevin from the membrane , and subsequent loss of [nNOS] , is *due* to the interaction . Negative_regulation NOS1 TNF 10755468 682761 In addition , either 0.4 mM SNP/Vc and 800 U/ml alone or 0.4 mM SNP/Vc and 400 U/ml TNFalpha in combination significantly increased malondialdehyde ( MDA ) content , but [nitric oxide synthase (NOS)] activity was *inhibited* only by SNP/Vc and TNF in combination . Negative_regulation NOS1 TNF 11223427 787883 Cerivastatin prevents *induced* downregulation of endothelial [nitric oxide synthase] : role of endothelial cytosolic proteins . Negative_regulation NOS1 TNF 11912559 925005 *inhibits* insulin induced increase in endothelial [nitric oxide synthase] and reduces insulin receptor content and phosphorylation in human aortic endothelial cells . Negative_regulation NOS1 TNF 14581470 1186872 *inhibits* endothelial [nitric-oxide synthase] gene promoter activity in bovine aortic endothelial cells . Negative_regulation NOS1 TNF 16260352 1477954 Serum , sTNFR-I , and asymmetric dimethylarginine ( ADMA ) , an endogenous *inhibitor* of [NOS] , in CD were significantly higher than in UD or NS . Negative_regulation NOS1 TNF 16827641 1586612 The *role* of in mediating pathophysiological activity of inducible [nitric oxide synthase] during transplant vasculopathy remains contentious . Negative_regulation NOS1 TNF 17172986 1679429 In vitro trehalose significantly blunted LPS induced extracellular regulated kinase ( LPS = 21 +/- 6 integrated intensity ; LPS + trehalose 100 mmol = 2 +/- 0.3 integrated intensity ) , c-jun-N terminal kinase ( LPS = 15 +/- 5 integrated intensity ; LPS + trehalose 100 mmol = 3.5 +/- 0.9 integrated intensity ) , and inducible [nitric oxide synthase] *activation* ( LPS = 12 +/- 3 integrated intensity ; LPS + trehalose 100 mmol = 1 +/- 0.09 integrated intensity ) , blunted IL-1beta ( LPS = 5 +/- 1.9 n-folds/beta-actin ; LPS + trehalose 100 mmol = 1.5 +/- 0.8 n-folds/beta-actin ) , IL-6 ( LPS = 4 +/- 1.5 n-folds/beta-actin ; LPS + trehalose 100 mmol = 1.4 +/- 0.5 n-folds/beta-actin ) , and ( LPS = 4.2 +/- 1.6 n-folds/beta-actin ; LPS + trehalose 100 mmol = 1.1 +/- 0.7 n-folds/beta-actin ) gene expression , and markedly reduced the release of inflammatory cytokines and nitrite content . Negative_regulation NOS1 TNF 18250144 1911447 Moreover , the inhibitor prolonged dependent E-selectin induction , *inhibited* endothelial [nitric oxide synthase] expression at both mRNA ( quantitative real-time polymerase chain reaction ) and protein level ( enzyme linked immunosorbent assay and western blot ) , and lowered bioactive nitric oxide output ( RFL-6 reporter cell assay ) . Negative_regulation NOS1 TNF 19353522 2064845 C/EBPbeta knockdown also inhibited the synergistic expression of CXCL1 , inducible [nitric oxide synthase] , and CCL5 in *response* to concomitant IFNgamma and . Negative_regulation NOS1 TNF 19939906 2319467 Sesamol inhibited serum , interleukin (IL)-1ß and nitrite production in LPS treated mice , and *inhibited* LPS induced inducible [nitric oxide synthase] expression in mouse leukocytes . Negative_regulation NOS1 TNF 7693276 231231 1. This study investigates the *role* of in the induction of [nitric oxide synthase (NOS)] by bacterial endotoxin ( lipopolysaccharide ; Negative_regulation NOS1 TNF 8779862 379914 *Roles* of IL-1 and in endotoxin induced activation of [nitric oxide synthase] in cultured rat brain cells . Negative_regulation NOS2 ALOX5 9806822 544953 Econazole , [iNOS] *inhibitor* , calmodulin antagonist , <5-lipoxygenase> and a specific thromboxane synthase inhibitor , at a 1 mg kg-1 dose significantly decreased the LPS induced increase in nitrite levels , but increased mortality 4 . Negative_regulation NOS2 ARSA 14705149 1196270 In brain tissue subjected to hypoxia , *reduced* oxidative stress and [iNOS] activity ( all increased by hypoxia ) , but only when used at higher concentrations . Negative_regulation NOS2 ARSA 17503181 1841467 We evaluated indomethacin induced enteropathy in rats , in relation to the expression of the inducible isoform of NO synthase (iNOS) using aminosalicylic acid ( 5-ASA ) , its isomer <4-ASA> ( 10 or 50 mg/kg/day , po ) , and dexamethasone , an [iNOS] transcription *inhibitor* ( 3 mg/kg/day , sc ) . Negative_regulation NOS2 CAPN8 10835326 699110 *Role* of in hypoxic inhibition of [nitric oxide synthase] activity in pulmonary endothelial cells . Negative_regulation NOS2 CAPN8 16100081 1466402 Involvement of in cigarette smoke *induced* inhibition of lung endothelial [nitric oxide synthase] . Negative_regulation NOS2 CD14 19121070 2019408 Cells were stimulated directly with A. actinomycetemcomitans lipopolysaccharide or pretreated with the following l-NIL ( an [iNOS] *inhibitor* ) , , Toll-like receptor 2 (TLR2) , or TLR4 antibody before stimulation with A. actinomycetemcomitans lipopolysaccharide . Negative_regulation NOS2 CEACAM6 17878764 1797107 *reduced* the [iNOS] expression . Negative_regulation NOS2 CST6 11238649 790894 mRNA expression and flow cytometric analysis of infected spleen cells suggested that and IFN-gamma treatment , in addition to greatly reducing parasite numbers , *resulted* in reduced levels of IL-4 but increased levels of IL-12 and [inducible NO synthase] . Negative_regulation NOS2 EDN2 12193095 981014 *stimulates* an endogenous [nitric oxide synthase] inhibitor , asymmetric dimethylarginine , in experimental heart failure . Negative_regulation NOS2 EDN2 18973526 2086077 The *roles* of the receptors A and B ( ET ( A ) and ET ( B ) ) in CsA enhanced expression of PCNA and [iNOS] were examined in cultured human gingival fibroblasts pretreated with receptor antagonists , by immunocytochemistry and RT-PCR , respectively . Negative_regulation NOS2 EPHB2 16033422 1436187 In contrast , both and JNK inhibitor pretreatments only partially ( approximately 50 % ) *inhibited* the IL-1beta induced [iNOS] expression in the spinal cord . Negative_regulation NOS2 EPHB2 22197135 2544122 Viscolin blocked the expression of [iNOS] and COX-2 , and it also *inhibited* the for the activation of NF-?B in LPS stimulated RAW 264.7 macrophages . Negative_regulation NOS2 FAS 14615069 1163717 receptor activation also increased the generation of reactive oxygen species , and N-acetylcysteine , a well-known antioxidant , could *block* Fas mediated [iNOS] induction . Negative_regulation NOS2 FOLR1 10997722 734081 also inhibited the induction of the calcium independent NOS activity and *reduced* the levels of [iNOS] protein in rat forebrain slices subjected to OGD . Negative_regulation NOS2 FOLR1 22327861 2586505 Furthermore , *inhibited* [inducible nitric oxide synthase (iNOS)] activities in RAW macrophages . Negative_regulation NOS2 HSD11B2 19776225 2232016 In contrast , overexpression of <11 beta-HSD1> further *augmented* TNF-alpha induced [iNOS] , IL-6 , and MCP-1 expression . Negative_regulation NOS2 IGFBP1 7499972 336126 Taken together , these data indicate that activities are *involved* in the regulation of [iNOS] gene expression in murine macrophages . Negative_regulation NOS2 IGFBP1 9575170 502596 This study suggests that the *stimulation* of [iNOS] expression in astrocytes by inhibitors of is possibly due to the stimulation of NF-kappaB activation ; Negative_regulation NOS2 IL1B 11222532 787669 The purpose of these studies was to investigate the *role* of interferon-gamma (IFN-gamma) , tumor necrosis factor-alpha (TNF-alpha) , , and transforming growth factor-beta ( TGF-beta ) in the regulation of inducible [nitric oxide synthase] ( NOS2 ) activity in rabbit corneal cells . Negative_regulation NOS2 IL1B 11557585 861412 These data suggest that a broad intracellular signaling response to in rat pulmonary artery smooth muscle cells *results* in elevated levels of [iNOS] that is opposed by the geranylgeranylated small G protein Rho as well as the p38 and JAK2 pathways . Negative_regulation NOS2 IL1B 11736735 885816 The intestinal anti-inflammatory effect of morin was accompanied by a significant reduction in colonic leukotriene B4 and levels , improvement in colonic oxidative stress and *inhibition* of colonic [nitric oxide synthase] activity . Negative_regulation NOS2 IL1B 14503852 1144641 Astaxanthin also suppressed the serum levels of NO , PGE2 , TNF-alpha , and in LPS administrated mice , and *inhibited* NF-kappaB activation as well as [iNOS] promoter activity in RAW264.7 cells stimulated with LPS . Negative_regulation NOS2 IL1B 15229242 1269007 In vivo administration of PDMP after SCI resulted in improved functional outcome ( Basso , Beattie , Bresnahan score ) ; *inhibition* of [iNOS] , TNF-alpha , and expression ; decreased neuronal apoptosis ; and decreased tissue necrosis and demyelination . Negative_regulation NOS2 IL1B 16707097 1564046 *activated* the extracellular signal regulated kinase 1/2 ( ERK1/2 ) , and this activation was also enhanced by H ( 2 ) S. Inhibition of ERK1/2 activation by the selective inhibitor U0126 inhibited IL-1beta induced NF-kappaB activation , [iNOS] expression , and NO production either in the absence or presence of H ( 2 ) S . Negative_regulation NOS2 IL1B 17923423 1888910 Cartilage explants were subjected to treatment with TNF-alpha ( 100ng/ml ) , ( 10 ng/ml ) and to the [nitric oxide synthase] *inhibitor* , N-methyl-arginine ( L-NMA ; 1.25 mM ) for 26 , 50 or 120 h ( 5 days ) . Negative_regulation NOS2 IL1B 17931811 1819694 In lipopolysaccharide (LPS) stimulated RAW264.7 cells , HMCO5 inhibited NF-kappaB activation as well as [iNOS] promoter activity , *inhibited* the secretion of TNF-alpha and , and directly inhibited the intracellular accumulation of reactive oxygen species . Negative_regulation NOS2 IL1B 20712904 2317878 Resveratrol inhibited LPS induced expression and release of TNF-alpha , IL-6 , MCP-1 , and [iNOS/NO] in both cell types with more potency in microglia , and *inhibited* LPS induced expression of in microglia but not astrocytes . Negative_regulation NOS2 IL1B 20717505 2306736 AF pellet in NCCM significantly decreased the expression of [iNOS] and COX-2 in *response* to 1ng/ml , stimulation at 24 hours ( p < 0.05 ) . Negative_regulation NOS2 IL1B 8662883 367477 Inhibition of de novo BH4 synthesis with 2,4-diamino-6-hydroxypyrimidine ( DAHP ) significantly attenuated [iNOS] activity as well as mRNA and protein expression in *response* to plus tumor necrosis factor alpha ( IL-1beta/TNF-alpha ) . Negative_regulation NOS2 IL1B 9259476 448703 Furthermore , our results indicate a decisive *role* of in [iNOS] expression and NO generation . Negative_regulation NOS2 ITGB2 10880532 709206 IFN-gamma mediated apoptosis was abolished by depleting adherent cells or ( + ) spleen cells or by *inhibiting* [nitric oxide synthase] . Negative_regulation NOS2 MAP2K6 14581482 1186925 Either PD98059 or U0126 , selective inhibitors of , or overexpression of a dominant negative MEK-1 inhibited interleukin-1beta- *induced* ERK activation and the expression of [iNOS] and COX-2 but had essentially no effect on the expression of VCAM-1 and Mn-SOD . Negative_regulation NOS2 MAP2K6 16806046 1625161 In contrast , PD98059 , a specific inhibitor of that acts immediately upstream of classic MAP kinase , *had* no effect on the induction of [iNOS] , NO or DNA fragmentation in the cells . Negative_regulation NOS2 MAP2K6 9446561 483517 Inhibition of LPS mediated as well as LPS and ceramide mediated induction of [iNOS] and *activation* of NF-kappaB by PD98059 , a specific inhibitor of activation of mitogen activated protein (MAP) kinase kinase ( ) , and FPT inhibitor II , a selective inhibitor of Ras farnesyl protein transferase , indicate that the Ras-MAP kinase pathway is involved in LPS-ceramide induced activation of NF-kappaB and induction of iNOS , and that ceramide mediated signaling events probably converge into the LPS modulated MAP kinase signaling pathway resulting in greater activation of NF-kappaB and iNOS induction . Negative_regulation NOS2 PECAM1 15985432 1441185 Tie2 and expression decreased > 80 % after siRNA treatment , and flow stimulated phosphorylation of ERK1/2 , Akt , and endothelial [nitric oxide synthase] was significantly *inhibited* by Tie2 and PECAM1 siRNA . Negative_regulation NOS2 PLAT 17717150 1801470 In conclusion , our results demonstrate that after MCAO the interaction between and LRP *results* in NF-kappaB activation in astrocytes and induction of inducible [nitric-oxide synthase] expression in the ischemic tissue , suggesting a cytokine-like plasminogen independent role for tPA during cerebral ischemia . Negative_regulation NOS2 S100B 19558426 2142524 LPS + IFN-gamma induced S100B up-regulation was not affected by budesonide , while [iNOS] expression and NO production were significantly *inhibited* by both specific anti-RAGE and blocking antibodies . Negative_regulation NOS2 S100B 19961838 2199392 Albumin activated ERK1/2 , p38 MAPK and JNK signaling pathways in astrocytes , and *induced* the production of interleukin (IL)-1beta , [inducible nitric oxide (NO) synthase] , the NO metabolite nitrite , and the chemokine CX3CL1 while reducing the level of . Negative_regulation NOS2 SPHK1 20036321 2200443 Suppression of by its inhibitor , N , N Dimethylsphingosine ( DMS ) , or siRNA *resulted* in decreased mRNA expression of TNF-alpha , IL-1beta , and [iNOS] and release of TNF-alpha and nitric oxide ( NO ) in LPS activated microglia . Negative_regulation NOS2 SRGN 23570999 2783229 Wattakaka volubilis steroidal glycoside mixture ( WVSM ) and ( 1-50 µM ) significantly *inhibited* the COX-2 and [iNOS] enzymes resulting in low levels of PGE2 and NO in LPS induced RAW 264.7 macrophage cells . Negative_regulation NOS2 STK39 18621907 1966331 Together , the data demonstrate a central *role* of in the upregulation of both arginase II and [iNOS] in bPAEC in response to L/T treatment . Negative_regulation NOS2 TNF 10224371 610185 In addition , Ro 31-8220 ( a PKC inhibitor ) inhibited OX8 induced [iNOS] upregulation , NO and IL-1beta production , but did not *inhibit* production . Negative_regulation NOS2 TNF 10417671 631634 Treatment with anti-TNF-alpha mAb did not affect the expression of IFN-gamma in the LPC but inhibited expression of iNOS in the infected mice , indicating the *role* of in the induction of [iNOS] . Negative_regulation NOS2 TNF 10705297 673071 Therefore , in the present study , we investigated the *role* of endogenous IFN-gamma , and IL-10 in the regulation of LPS induced tissue [iNOS] expression in the major organs . Negative_regulation NOS2 TNF 10705297 673077 Immunohistochemical staining for iNOS and determination of iNOS activity indicated that iNOS expression was mainly upregulated in the small intestine , lung and heart , and that IFN-gamma , as well as IL-10 are *involved* in the regulation of [iNOS] expression and enzyme activity . Negative_regulation NOS2 TNF 11223427 787884 Cerivastatin prevents *induced* downregulation of endothelial [nitric oxide synthase] : role of endothelial cytosolic proteins . Negative_regulation NOS2 TNF 11912559 925006 *inhibits* insulin induced increase in endothelial [nitric oxide synthase] and reduces insulin receptor content and phosphorylation in human aortic endothelial cells . Negative_regulation NOS2 TNF 12526099 1028253 These results indicate that RAs attenuate [iNOS] expression reversibly in TNF stimulated 3T3-L1 adipocytes , and that the induced LPL suppression is not the *result* of NO overproduction . Negative_regulation NOS2 TNF 12832676 1105790 L-NAME and the eNOS inhibitor N ( 5 ) - ( 1-iminoethyl ) -ornithine ( L-NIO ) enhanced O ( 2 ) ( *- ) formation from PA ( with endothelium ) in *response* to IL-1alpha and but had no effect on LPS mediated O ( 2 ) ( *- ) formation , whereas L-NAME and the [iNOS] inhibitor L-N ( 6 ) - ( 1-iminoethyl ) -lysine-HCl ( L-NIL ) enhanced O ( 2 ) ( *- ) formation only in response to LPS . Negative_regulation NOS2 TNF 14503852 1144640 Astaxanthin also suppressed the serum levels of NO , PGE2 , , and IL-1beta in LPS administrated mice , and *inhibited* NF-kappaB activation as well as [iNOS] promoter activity in RAW264.7 cells stimulated with LPS . Negative_regulation NOS2 TNF 14581470 1186873 *inhibits* endothelial [nitric-oxide synthase] gene promoter activity in bovine aortic endothelial cells . Negative_regulation NOS2 TNF 16827641 1586613 The *role* of in mediating pathophysiological activity of inducible [nitric oxide synthase] during transplant vasculopathy remains contentious . Negative_regulation NOS2 TNF 17172986 1679431 In vitro trehalose significantly blunted LPS induced extracellular regulated kinase ( LPS = 21 +/- 6 integrated intensity ; LPS + trehalose 100 mmol = 2 +/- 0.3 integrated intensity ) , c-jun-N terminal kinase ( LPS = 15 +/- 5 integrated intensity ; LPS + trehalose 100 mmol = 3.5 +/- 0.9 integrated intensity ) , and inducible [nitric oxide synthase] *activation* ( LPS = 12 +/- 3 integrated intensity ; LPS + trehalose 100 mmol = 1 +/- 0.09 integrated intensity ) , blunted IL-1beta ( LPS = 5 +/- 1.9 n-folds/beta-actin ; LPS + trehalose 100 mmol = 1.5 +/- 0.8 n-folds/beta-actin ) , IL-6 ( LPS = 4 +/- 1.5 n-folds/beta-actin ; LPS + trehalose 100 mmol = 1.4 +/- 0.5 n-folds/beta-actin ) , and ( LPS = 4.2 +/- 1.6 n-folds/beta-actin ; LPS + trehalose 100 mmol = 1.1 +/- 0.7 n-folds/beta-actin ) gene expression , and markedly reduced the release of inflammatory cytokines and nitrite content . Negative_regulation NOS2 TNF 17207792 1695790 Taken together , our data indicate that the anti-inflammatory and antinociceptive properties of siegeskaurolic acid may be due to [iNOS] , COX-2 and *inhibition* via the down-regulation of NF-kappaB binding activity . Negative_regulation NOS2 TNF 17632098 1780009 In lipopolysaccharide from Escherichia coli ( LPS ) -treated RAW 264.7 macrophages , NCX 6560 reduced [iNOS] expression and dimer assembly more efficiently than atorvastatin and *inhibited* nitrite accumulation ( IC ( 50 ) =6.7+/-1.6 microM ) and release . Negative_regulation NOS2 TNF 17931811 1819693 In lipopolysaccharide (LPS) stimulated RAW264.7 cells , HMCO5 inhibited NF-kappaB activation as well as [iNOS] promoter activity , *inhibited* the secretion of and IL-1beta , and directly inhibited the intracellular accumulation of reactive oxygen species . Negative_regulation NOS2 TNF 18250144 1911449 Moreover , the inhibitor prolonged dependent E-selectin induction , *inhibited* endothelial [nitric oxide synthase] expression at both mRNA ( quantitative real-time polymerase chain reaction ) and protein level ( enzyme linked immunosorbent assay and western blot ) , and lowered bioactive nitric oxide output ( RFL-6 reporter cell assay ) . Negative_regulation NOS2 TNF 18606162 1947245 However , blockade of TNF-alpha action and COX-2 activity with anti-TNF-alpha antibodies and indomethacin , respectively , revealed that modulation of and COX-2 was not *involved* in adenosine mediated [iNOS] suppression . Negative_regulation NOS2 TNF 19353522 2064847 C/EBPbeta knockdown also inhibited the synergistic expression of CXCL1 , inducible [nitric oxide synthase] , and CCL5 in *response* to concomitant IFNgamma and . Negative_regulation NOS2 TNF 19939906 2319469 Sesamol inhibited serum , interleukin (IL)-1ß and nitrite production in LPS treated mice , and *inhibited* LPS induced inducible [nitric oxide synthase] expression in mouse leukocytes . Negative_regulation NOS2 TNF 22303922 2668274 SPEE treatment significantly inhibited the LPS induced production of NO , prostaglandin E ( 2 ) , interleukin-6 , and and *inhibited* the expression of [iNOS] and COX-2 via attenuation of NF-?B p65 expression . Negative_regulation NOS2 TNF 22953812 2667618 Fucosterol suppressed the expressions of [inducible nitric oxide synthase (iNOS)] , tumour necrosis factor-a (TNF-a) , and interleukin-6 (IL-6) by downregulating their transcriptions , and subsequently *inhibited* the productions of nitric oxide , , and IL-6 . Negative_regulation NOS2 TNF 23243434 2708703 In addition , TSAV attenuated the serum and IL-6 levels and *inhibited* the serum [iNOS] and NO levels . Negative_regulation NOS2 TNF 23815760 2870678 Compounds 1-6 also exhibited inhibition of *induced* expression of iNOS and ICAM-1 mRNA and dose dependent inhibition of [iNOS] promoter activity , with IC50 values ranging from 3.3 to 5.0 µM . Negative_regulation NOS2 TNF 23877917 2830194 Consistent with these observations , echinocystic acid concentration-dependently inhibited lipopolysaccharide induced inducible nitric oxide synthase expression at the protein level and inducible nitric oxide synthase , , and interleukin-6 expression at the mRNA level , and *inhibited* lipopolysaccharide induced [iNOS] promoter binding activity . Negative_regulation NOS2 TNF 7513694 253778 The *role* of endogenous and interferon-beta (IFN-beta) in lipopolysaccharide (LPS) induced activation of the [inducible nitric-oxide synthase (i-NOS)] gene was investigated . Negative_regulation NOS2 TNF 7759887 307853 Synergy between IFN-gamma and taxol was mainly dependent on taxol induced TNF-alpha secretion because not only the increase of [inducible NO synthase (iNOS)] gene expression by rIFN-gamma plus taxol was associated with the increased expression of TNF-alpha gene but also taxol induced NO production was decreased by the treatment of anti-murine TNF-alpha neutralizing Abs. STSN and polymyxin B potently *inhibited* taxol induced secretion and TNF-alpha gene expression as well as iNOS gene expression by rIFN-gamma plus taxol . Negative_regulation NOS2 TNF 8779862 379916 *Roles* of IL-1 and in endotoxin induced activation of [nitric oxide synthase] in cultured rat brain cells . Negative_regulation NOS2 TNF 9168934 432677 Cisplatin induced mRNA expression , and an anti-TNF-alpha neutralizing antibody *inhibited* the induction of [iNOS] expression by a combination of cisplatin and IFN-gamma in NB-39-nu cells . Negative_regulation NOS2 TNF 9761373 536761 Production of gamma-interferon ( IFN-gamma ) and in Trypanosoma cruzi infected mice *results* in the activation of [inducible nitric oxide synthase (iNOS)] and in elevated nitric oxide ( NO ) synthesis , which is important for the macrophage trypanocidal activity . Negative_regulation NOS3 ARSA 17218764 1664116 Furthermore , in comparison to plain ASA , *caused* stronger inhibition of [cNOS] and increase in iNOS expression in the gastric mucosa . Negative_regulation NOS3 CAPN8 10835326 699124 *Role* of in hypoxic inhibition of [nitric oxide synthase] activity in pulmonary endothelial cells . Negative_regulation NOS3 CAPN8 15793253 1386947 Immunoprecipitation studies revealed *dependent* loss of association between [eNOS] and the regulatory protein heat shock protein 90 . Negative_regulation NOS3 CAPN8 16100081 1466417 Involvement of in cigarette smoke *induced* inhibition of lung endothelial [nitric oxide synthase] . Negative_regulation NOS3 CAPN8 16100081 1466446 In this study , we evaluated the *role* of in CSE induced decrease in [eNOS] gene expression . Negative_regulation NOS3 CAPN8 16100081 1466535 To investigate whether CSE induced inhibition of [eNOS] gene expression is *caused* by decreased activity due to an increase in calpastatin protein content , we cloned calpastatin gene from PAEC and constructed adenovirus vectors containing calpastatin . Negative_regulation NOS3 EDN2 12193095 981017 *stimulates* an endogenous [nitric oxide synthase] inhibitor , asymmetric dimethylarginine , in experimental heart failure . Negative_regulation NOS3 EDN2 12623978 1066548 however , exogenous failed to normalize osmotically increased NPR-A activity or expression , or osmotically *suppressed* [eNOS] expression . Negative_regulation NOS3 EPHB2 20870034 2343058 In conclusion , KMUP-1 inhibits MCT induced PA proliferation by binding to 5-HT(2A) , 5-HT(2B) and 5-HT(2C) receptors , increasing endothelial [eNOS/5-HT(2B)] receptor expression and NO release and *inhibiting* 5-HTT/RhoA/ROCK expression and phosphorylation . Negative_regulation NOS3 FOXO1 16100571 1448314 Consistent with these findings , constitutively active and Foxo3a *repressed* [eNOS] protein expression and bound to the eNOS promoter . Negative_regulation NOS3 HBEGF 18925469 1994482 However , the *role* of in regulation of [eNOS] has not yet been investigated . Negative_regulation NOS3 IL1B 11222532 787674 The purpose of these studies was to investigate the *role* of interferon-gamma (IFN-gamma) , tumor necrosis factor-alpha (TNF-alpha) , , and transforming growth factor-beta ( TGF-beta ) in the regulation of inducible [nitric oxide synthase] ( NOS2 ) activity in rabbit corneal cells . Negative_regulation NOS3 IL1B 11736735 885817 The intestinal anti-inflammatory effect of morin was accompanied by a significant reduction in colonic leukotriene B4 and levels , improvement in colonic oxidative stress and *inhibition* of colonic [nitric oxide synthase] activity . Negative_regulation NOS3 IL1B 16497991 1548952 BPS attenuated the *mediated* decrease in [eNOS] promoter activity and the expression of eNOS gene through PKA pathway . Negative_regulation NOS3 IL1B 16502366 1529046 As for proinflammatory cytokines , both TNF-alpha and substantially *down-regulated* the [eNOS] mRNA level ( p < 0.05 ) . Negative_regulation NOS3 IL1B 17923423 1888911 Cartilage explants were subjected to treatment with TNF-alpha ( 100ng/ml ) , ( 10 ng/ml ) and to the [nitric oxide synthase] *inhibitor* , N-methyl-arginine ( L-NMA ; 1.25 mM ) for 26 , 50 or 120 h ( 5 days ) . Negative_regulation NOS3 ITGB2 10880532 709207 IFN-gamma mediated apoptosis was abolished by depleting adherent cells or ( + ) spleen cells or by *inhibiting* [nitric oxide synthase] . Negative_regulation NOS3 MAP2K6 24769202 2936989 TNF-a mediated suppression of [eNOS] expression , mRNA stability , and 3'-untranslated region ( 3'UTR ) activity were *inhibited* by NF-?B inhibitors and Dicer knockdown , but not by p38 MAPK and inhibitors , suggesting the involvement of NF-?B-responsive miRNAs in eNOS expression . Negative_regulation NOS3 PDE5A 22230399 2519469 KMUP-1 ( 0.001-0.1 microM ) concentration dependently increased [eNOS] in normoxia and did not *inhibit* in hypoxic cells . Negative_regulation NOS3 PECAM1 15985432 1441187 Tie2 and expression decreased > 80 % after siRNA treatment , and flow stimulated phosphorylation of ERK1/2 , Akt , and endothelial [nitric oxide synthase] was significantly *inhibited* by Tie2 and PECAM1 siRNA . Negative_regulation NOS3 PECAM1 16118242 1454343 *Role* of in the shear-stress induced activation of Akt and the [endothelial nitric oxide synthase (eNOS)] in endothelial cells . Negative_regulation NOS3 PECAM1 16118242 1454352 Since a major constituent of these endothelial cell-cell contacts is the platelet endothelial cell adhesion molecule-1 ( PECAM-1 ) we assessed the *role* of in the activation of [eNOS] . Negative_regulation NOS3 PECAM1 21183735 2391098 The current study was conducted to determine the *role* of in the regulation of basal [eNOS] activity . Negative_regulation NOS3 PLAT 15625301 1362080 We hypothesized that *induces* an inhibition of [endothelial NO synthase (eNOS)] after focal ischemia that is responsible for ischemic damage and may be restored by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors . Negative_regulation NOS3 PLAT 15625301 1362081 Western blots of ischemic brain lysates showed that markedly *diminished* [eNOS] levels , increased extracellular regulated kinase (ERK)-2 , and decreased MAP kinase/p38 activity . Negative_regulation NOS3 PLAT 15625301 1362088 In a mouse model of focal cerebral ischemia , *induces* [eNOS] inhibition , ERK-2 activation , and p38 inhibition , possibly as part of a more complex signaling response exacerbating brain injury . Negative_regulation NOS3 PLAT 17717150 1801481 In conclusion , our results demonstrate that after MCAO the interaction between and LRP *results* in NF-kappaB activation in astrocytes and induction of inducible [nitric-oxide synthase] expression in the ischemic tissue , suggesting a cytokine-like plasminogen independent role for tPA during cerebral ischemia . Negative_regulation NOS3 RCAN1 12490546 1037819 Stimulation of transfected cells with AngII or specific AT2-receptor agonists resulted in a significant increase in [eNOS] promoter activity , which was *blocked* by CsA , , and mutation of an upstream NF-AT site . Negative_regulation NOS3 TNF 10393506 627205 In addition , *reduced* [eNOS] mRNA levels and this was prevented by coincubation with cycloheximide . Negative_regulation NOS3 TNF 11223427 787885 Cerivastatin prevents *induced* downregulation of endothelial [nitric oxide synthase] : role of endothelial cytosolic proteins . Negative_regulation NOS3 TNF 11223427 787886 The aim of the present study was to analyze the effect of cerivastatin , a novel HMG CoA reductase inhibitor , on *induced* downregulation of [eNOS] protein expression in bovine aortic endothelial cells ( BAEC ) . Negative_regulation NOS3 TNF 11223427 787887 Cerivastatin prevented *induced* downregulation of [eNOS] protein expression in a concentration dependent manner ( 10 ( -8 ) to 10 ( -5 ) M ) . Negative_regulation NOS3 TNF 11912559 925007 *inhibits* insulin induced increase in endothelial [nitric oxide synthase] and reduces insulin receptor content and phosphorylation in human aortic endothelial cells . Negative_regulation NOS3 TNF 11912559 925013 ( 1 to 5 ng/mL ) *caused* [e-NOS] inhibition in a dose dependent fashion as measured by Western blotting . Negative_regulation NOS3 TNF 14555463 1185980 *induces* a decrease in [eNOS] promoter activity . Negative_regulation NOS3 TNF 14555463 1185988 Our data indicate *causes* a decrease in [eNOS] promoter activity that may be mediated by GATA-4 and Sp3 . Negative_regulation NOS3 TNF 14581470 1186874 *inhibits* endothelial [nitric-oxide synthase] gene promoter activity in bovine aortic endothelial cells . Negative_regulation NOS3 TNF 16502366 1529045 As for proinflammatory cytokines , both and IL-1beta substantially *down-regulated* the [eNOS] mRNA level ( p < 0.05 ) . Negative_regulation NOS3 TNF 16827641 1586614 The *role* of in mediating pathophysiological activity of inducible [nitric oxide synthase] during transplant vasculopathy remains contentious . Negative_regulation NOS3 TNF 17031267 1630701 ( 10 ng/mL ) *reduced* the expression of [eNOS] protein . Negative_regulation NOS3 TNF 17172986 1679433 In vitro trehalose significantly blunted LPS induced extracellular regulated kinase ( LPS = 21 +/- 6 integrated intensity ; LPS + trehalose 100 mmol = 2 +/- 0.3 integrated intensity ) , c-jun-N terminal kinase ( LPS = 15 +/- 5 integrated intensity ; LPS + trehalose 100 mmol = 3.5 +/- 0.9 integrated intensity ) , and inducible [nitric oxide synthase] *activation* ( LPS = 12 +/- 3 integrated intensity ; LPS + trehalose 100 mmol = 1 +/- 0.09 integrated intensity ) , blunted IL-1beta ( LPS = 5 +/- 1.9 n-folds/beta-actin ; LPS + trehalose 100 mmol = 1.5 +/- 0.8 n-folds/beta-actin ) , IL-6 ( LPS = 4 +/- 1.5 n-folds/beta-actin ; LPS + trehalose 100 mmol = 1.4 +/- 0.5 n-folds/beta-actin ) , and ( LPS = 4.2 +/- 1.6 n-folds/beta-actin ; LPS + trehalose 100 mmol = 1.1 +/- 0.7 n-folds/beta-actin ) gene expression , and markedly reduced the release of inflammatory cytokines and nitrite content . Negative_regulation NOS3 TNF 18250144 1911451 Moreover , the inhibitor prolonged dependent E-selectin induction , *inhibited* endothelial [nitric oxide synthase] expression at both mRNA ( quantitative real-time polymerase chain reaction ) and protein level ( enzyme linked immunosorbent assay and western blot ) , and lowered bioactive nitric oxide output ( RFL-6 reporter cell assay ) . Negative_regulation NOS3 TNF 18688046 1961025 Furthermore , adenovirus mediated overexpression of eEF1A1 increased eNOS mRNA instability , whereas knockdown of eEF1A1 substantially attenuated *induced* destabilization of eNOS mRNA and downregulation of [eNOS] expression in HUVECs . Negative_regulation NOS3 TNF 18688046 1961026 These results indicate that eEF1A1 is a novel eNOS 3'-UTR binding protein that plays a critical role in mediating *induced* decrease in [eNOS] mRNA stability . Negative_regulation NOS3 TNF 19353522 2064849 C/EBPbeta knockdown also inhibited the synergistic expression of CXCL1 , inducible [nitric oxide synthase] , and CCL5 in *response* to concomitant IFNgamma and . Negative_regulation NOS3 TNF 19548191 2162489 The cardiovascular protective effect of RCLE seems to be due to an interplay of different factors : COX pathway activation , *inhibition* , [endothelial nitric oxide synthase (eNOS)] activation , and free radical and ROS scavenging . Negative_regulation NOS3 TNF 19939906 2319471 Sesamol inhibited serum , interleukin (IL)-1ß and nitrite production in LPS treated mice , and *inhibited* LPS induced inducible [nitric oxide synthase] expression in mouse leukocytes . Negative_regulation NOS3 TNF 20083573 2280889 HIV gp120 and synergistically *reduce* [eNOS] expression and cause endothelial dysfunction in both porcine coronary arteries and HCAECs . Negative_regulation NOS3 TNF 20353766 2255174 Pretreatment of HUVEC with an antioxidant ( superoxide dismutase , alpha-tocopherol ) or AT1 receptor blockers ( olmesartan or candesartan ) restored the *dependent* reduction of [eNOS] . Negative_regulation NOS3 TNF 20639218 2322049 Western blot analysis showed that [endothelial nitric oxide synthase (eNOS)] expression was *reduced* by in in vitro and in vivo experiments , whereas IL-10 restored the eNOS expression . Negative_regulation NOS3 TNF 23108656 2699215 Inhibition of miR-155 reversed *induced* downregulation of [eNOS] expression and impairment of endothelium dependent vasorelaxation . Negative_regulation NOS3 TNF 24769202 2936983 *mediated* suppression of [eNOS] expression , mRNA stability , and 3'-untranslated region ( 3'UTR ) activity were inhibited by NF-?B inhibitors and Dicer knockdown , but not by p38 MAPK and MEK inhibitors , suggesting the involvement of NF-?B-responsive miRNAs in eNOS expression . Negative_regulation NOS3 TNF 24769202 2937006 Transfection with antagomiR-155 blocked *mediated* suppression of [eNOS] 3'UTR activity , eNOS mRNA and protein levels , and NO and cGMP production . Negative_regulation NOS3 TNF 7538424 301284 The pharmacological generation of NO using sodium nitroprusside ( 10 mumol/L ) and S-nitroso-acetylpenicillamine ( 100 to 400 mumol/L ) had no effect on cNOS mRNA levels , and *induced* downregulation of [cNOS] was not prevented by coincubation with the inhibitors of NO synthesis N omega-nitro-L-arginine methyl ester ( 1 mmol/L ) and NG-monomethyl L-arginine ( 10 mmol/L ) . Negative_regulation NOS3 TNF 7685252 219751 markedly *reduced* [cNOS] mRNA levels in HUVECs in a dose- and time dependent manner . Negative_regulation NOS3 TNF 7685252 219752 As little as 0.1 ng/mL *reduced* [cNOS] mRNA levels by 50 % . Negative_regulation NOS3 TNF 7685252 219753 *induced* reductions in [cNOS] mRNA levels may have an important effect on impaired endothelium mediated vasorelaxation in atherosclerosis . Negative_regulation NOS3 TNF 8779862 379918 *Roles* of IL-1 and in endotoxin induced activation of [nitric oxide synthase] in cultured rat brain cells . Negative_regulation NOS3 TNFSF10 16229016 1517956 Although an important factor that regulates eNOS activity is its localization within the cells , little is known about the *role* of in the regulation of [eNOS] trafficking among cellular compartments and the cytoskeleton involvement in this machinery . Negative_regulation NOSTRIN RAC1 22751148 2634457 NOSTRIN forms a complex with the GTPase Rac1 and its exchange factor Sos1 and overexpression of [NOSTRIN] in cells *induces* activation . Negative_regulation NOTCH1 CTGF 18583340 1946714 overexpression *suppressed* [Notch] signaling and induced the transcription of hairy and E (spl)-1 ( HES)-1 , by Notch independent mechanisms . Negative_regulation NOTCH1 CTGF 18583340 1946728 Down-regulation of *enhanced* [Notch] signaling and decreased HES-1 transcription and NFAT transactivation . Negative_regulation NOTCH1 F2R 19686683 2126361 The phosphorylation of Mib by *results* in Mib degradation , repression of [Notch] signaling , and stimulation of neuronal differentiation . Negative_regulation NOTCH1 ID1 19564409 2117365 *attenuates* [Notch] signaling and impairs T-cell commitment by elevating Deltex1 expression . Negative_regulation NOTCH1 JAG1 17652726 1776192 The activation of Notch by *resulted* in the upregulation of active forms of [Notch1] and 2 proteins ( P < 0.05 ) , with a concurrent increase in Ki67 ( P < 0.05 ) and a decrease in CK3 ( P < 0.05 ) expression . Negative_regulation NOTCH1 JAG1 21820430 2477007 In this study , we have demonstrated that the *inhibits* [Notch1] signaling via a reduction in the protein stability of the Notch1 intracellular domain (Notch1-IC) . Negative_regulation NOTCH1 JAG1 21890747 2501316 We further determined that the reduced [Notch-1] activation was *due* to reduction in the ligand and two critical components of the ?-secretase enzyme complex presenilin-1 and nicastrin . Negative_regulation NOTCH1 JAG1 23116754 2751042 In the further experiments , down-regulation of Notch signaling was shown to be critical for BM-MSCs to differentiate into hepatocytes , as increased *resulted* in up-regulated [Notch] activation leading to higher levels of expression of Hes1 and Hey1 , which completely blocked Albumin expresion in BM-MSCs . Negative_regulation NOTCH1 JAG1 24191040 2868525 Reducing the expression of and 2 in the Mgp ( -/- ) mice by crossing them with Jagged 1 or 2 deficient mice *reduces* [Notch] activity , normalizes endothelial differentiation , and prevents cerebral AVMs , but not pulmonary or renal AVMs . Negative_regulation NOTCH1 MAML3 21640102 2446199 Overexpression of by retroviral transduction in CaSki cells *resulted* in significant decreases in the mRNA levels of Hes1 and [Notch1] but had no effects on the levels of MAML1 , p53 or HPV E6/E7 . Negative_regulation NOTCH1 MMP7 18239463 1890508 We propose that during development and stem cell maintenance , Notch activation is highly regulated by the binding of Notch ligand to receptor and employs the ubiquitously expressed ADAMs , whereas in a disease state , high levels of induced activity can *lead* to aberrant ligand independent [Notch] activation . Negative_regulation NOTCH1 NRARP 12794108 1097987 *inhibits* [Notch1] signaling : multiple Notch1 signaling pathways involved in T cell development . Negative_regulation NOTCH1 NRARP 12794108 1097992 In AKR1010 thymoma cells , overexpression *blocks* CBF-1 dependent transcriptional activation of [Notch-responsive] genes and inhibits phenotypic changes associated with Notch activation . Negative_regulation NOTCH1 TNF 21593384 2441511 With regard to pDCs , [Notch] activation *induced* TNF-a whereas Notch inhibition significantly abrogated the secretion of CCL19 , CXCL9 , CXCL10 , and . Negative_regulation NOTCH2 CTGF 18583340 1946715 overexpression *suppressed* [Notch] signaling and induced the transcription of hairy and E (spl)-1 ( HES)-1 , by Notch independent mechanisms . Negative_regulation NOTCH2 CTGF 18583340 1946729 Down-regulation of *enhanced* [Notch] signaling and decreased HES-1 transcription and NFAT transactivation . Negative_regulation NOTCH2 F2R 19686683 2126362 The phosphorylation of Mib by *results* in Mib degradation , repression of [Notch] signaling , and stimulation of neuronal differentiation . Negative_regulation NOTCH2 ID1 19564409 2117366 *attenuates* [Notch] signaling and impairs T-cell commitment by elevating Deltex1 expression . Negative_regulation NOTCH2 JAG1 23116754 2751043 In the further experiments , down-regulation of Notch signaling was shown to be critical for BM-MSCs to differentiate into hepatocytes , as increased *resulted* in up-regulated [Notch] activation leading to higher levels of expression of Hes1 and Hey1 , which completely blocked Albumin expresion in BM-MSCs . Negative_regulation NOTCH2 JAG1 24191040 2868526 Reducing the expression of and 2 in the Mgp ( -/- ) mice by crossing them with Jagged 1 or 2 deficient mice *reduces* [Notch] activity , normalizes endothelial differentiation , and prevents cerebral AVMs , but not pulmonary or renal AVMs . Negative_regulation NOTCH2 MMP7 18239463 1890509 We propose that during development and stem cell maintenance , Notch activation is highly regulated by the binding of Notch ligand to receptor and employs the ubiquitously expressed ADAMs , whereas in a disease state , high levels of induced activity can *lead* to aberrant ligand independent [Notch] activation . Negative_regulation NOTCH2 NRARP 12794108 1097993 In AKR1010 thymoma cells , overexpression *blocks* CBF-1 dependent transcriptional activation of [Notch-responsive] genes and inhibits phenotypic changes associated with Notch activation . Negative_regulation NOTCH2 TNF 21593384 2441514 With regard to pDCs , [Notch] activation *induced* TNF-a whereas Notch inhibition significantly abrogated the secretion of CCL19 , CXCL9 , CXCL10 , and . Negative_regulation NOTCH3 CTGF 18583340 1946716 overexpression *suppressed* [Notch] signaling and induced the transcription of hairy and E (spl)-1 ( HES)-1 , by Notch independent mechanisms . Negative_regulation NOTCH3 CTGF 18583340 1946730 Down-regulation of *enhanced* [Notch] signaling and decreased HES-1 transcription and NFAT transactivation . Negative_regulation NOTCH3 F2R 19686683 2126363 The phosphorylation of Mib by *results* in Mib degradation , repression of [Notch] signaling , and stimulation of neuronal differentiation . Negative_regulation NOTCH3 ID1 19564409 2117367 *attenuates* [Notch] signaling and impairs T-cell commitment by elevating Deltex1 expression . Negative_regulation NOTCH3 JAG1 23116754 2751044 In the further experiments , down-regulation of Notch signaling was shown to be critical for BM-MSCs to differentiate into hepatocytes , as increased *resulted* in up-regulated [Notch] activation leading to higher levels of expression of Hes1 and Hey1 , which completely blocked Albumin expresion in BM-MSCs . Negative_regulation NOTCH3 JAG1 24191040 2868527 Reducing the expression of and 2 in the Mgp ( -/- ) mice by crossing them with Jagged 1 or 2 deficient mice *reduces* [Notch] activity , normalizes endothelial differentiation , and prevents cerebral AVMs , but not pulmonary or renal AVMs . Negative_regulation NOTCH3 MMP7 18239463 1890510 We propose that during development and stem cell maintenance , Notch activation is highly regulated by the binding of Notch ligand to receptor and employs the ubiquitously expressed ADAMs , whereas in a disease state , high levels of induced activity can *lead* to aberrant ligand independent [Notch] activation . Negative_regulation NOTCH3 NRARP 12794108 1097994 In AKR1010 thymoma cells , overexpression *blocks* CBF-1 dependent transcriptional activation of [Notch-responsive] genes and inhibits phenotypic changes associated with Notch activation . Negative_regulation NOTCH3 TNF 21593384 2441517 With regard to pDCs , [Notch] activation *induced* TNF-a whereas Notch inhibition significantly abrogated the secretion of CCL19 , CXCL9 , CXCL10 , and . Negative_regulation NOTCH4 CTGF 18583340 1946717 overexpression *suppressed* [Notch] signaling and induced the transcription of hairy and E (spl)-1 ( HES)-1 , by Notch independent mechanisms . Negative_regulation NOTCH4 CTGF 18583340 1946731 Down-regulation of *enhanced* [Notch] signaling and decreased HES-1 transcription and NFAT transactivation . Negative_regulation NOTCH4 F2R 19686683 2126364 The phosphorylation of Mib by *results* in Mib degradation , repression of [Notch] signaling , and stimulation of neuronal differentiation . Negative_regulation NOTCH4 ID1 19564409 2117368 *attenuates* [Notch] signaling and impairs T-cell commitment by elevating Deltex1 expression . Negative_regulation NOTCH4 JAG1 23116754 2751045 In the further experiments , down-regulation of Notch signaling was shown to be critical for BM-MSCs to differentiate into hepatocytes , as increased *resulted* in up-regulated [Notch] activation leading to higher levels of expression of Hes1 and Hey1 , which completely blocked Albumin expresion in BM-MSCs . Negative_regulation NOTCH4 JAG1 24191040 2868528 Reducing the expression of and 2 in the Mgp ( -/- ) mice by crossing them with Jagged 1 or 2 deficient mice *reduces* [Notch] activity , normalizes endothelial differentiation , and prevents cerebral AVMs , but not pulmonary or renal AVMs . Negative_regulation NOTCH4 MMP7 18239463 1890511 We propose that during development and stem cell maintenance , Notch activation is highly regulated by the binding of Notch ligand to receptor and employs the ubiquitously expressed ADAMs , whereas in a disease state , high levels of induced activity can *lead* to aberrant ligand independent [Notch] activation . Negative_regulation NOTCH4 NRARP 12794108 1097995 In AKR1010 thymoma cells , overexpression *blocks* CBF-1 dependent transcriptional activation of [Notch-responsive] genes and inhibits phenotypic changes associated with Notch activation . Negative_regulation NOTCH4 TNF 21593384 2441520 With regard to pDCs , [Notch] activation *induced* TNF-a whereas Notch inhibition significantly abrogated the secretion of CCL19 , CXCL9 , CXCL10 , and . Negative_regulation NOV CTGF 18597638 1972267 The lack of *caused* upregulation of [CCN3] in CCN2-null mice , which resulted in the observed phenotypes , such as the resultant delay of terminal differentiation . Negative_regulation NOV EPHB2 21618206 2480970 However , p38 and inhibitors *blocked* suppression of [CCN3] by TGFß , suggesting involvement of these signaling pathways in the regulation of CCN3 . Negative_regulation NOX1 ARSA 22306536 2565222 Recent studies show that not only blocks cyclooxygenase , but also *inhibits* [NADPH oxidase] and resultant reactive oxygen species ( ROS ) generation , a pathway that underlies pathogenesis of several ailments , including hypertension and tissue remodeling after injury . Negative_regulation NOX1 ARSA 22306536 2565230 In this study , we examined if would *inhibit* [NADPH oxidase] activation , upregulation of AT1R transcription , and subsequent collagen generation in mouse cardiac fibroblasts challenged with Ang II . Negative_regulation NOX1 ARSA 22306536 2565240 also *suppressed* the expression of [NADPH oxidase] subunits ( p22(phox) , p47(phox) , p67(phox) , NOX2 and NOX4 ) and ROS generation . Negative_regulation NOX1 ARSA 22306536 2565246 These observations suggest that *inhibits* Ang II-induced [NADPH oxidase] expression , NF-?B activation and AT1R transcription in cardiac fibroblasts , and fibroblast proliferation and collagen expression . Negative_regulation NOX1 MAP2K6 17854274 1810462 Constitutively active and wild-type enhanced Rac-GTPase activity in vitro , and their overexpression *inhibited* PMA induced [NADPH oxidase] activation in RAW cells . Negative_regulation NOX1 MMP28 17543193 1668508 The endothelial cell NADPH oxidase and endothelial cell activities are *required* for VCAM-1 dependent lymphocyte migration as determined by scavenging of ROS , by pharmacologic or antisense inhibition of [NADPH oxidase] and by pharmacologic inhibition of endothelial cell MMPs . Negative_regulation NOX1 MMP7 17543193 1668523 The endothelial cell NADPH oxidase and endothelial cell activities are *required* for VCAM-1 dependent lymphocyte migration as determined by scavenging of ROS , by pharmacologic or antisense inhibition of [NADPH oxidase] and by pharmacologic inhibition of endothelial cell MMPs . Negative_regulation NOX1 RGS2 22120521 2535187 We find that ( RGS2 ) *inhibits* STAT3 mediated [Nox1] transcription , and can itself be repressed by TLR2 ; Negative_regulation NOX1 TNF 19450605 2096926 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated [gp91(phox)-NADPH oxidase] expression and activity , decreased phosphorylation of ERK1/2/p38 MAPK and *inhibited* cardiac expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation NOX3 ARSA 22306536 2565223 Recent studies show that not only blocks cyclooxygenase , but also *inhibits* [NADPH oxidase] and resultant reactive oxygen species ( ROS ) generation , a pathway that underlies pathogenesis of several ailments , including hypertension and tissue remodeling after injury . Negative_regulation NOX3 ARSA 22306536 2565231 In this study , we examined if would *inhibit* [NADPH oxidase] activation , upregulation of AT1R transcription , and subsequent collagen generation in mouse cardiac fibroblasts challenged with Ang II . Negative_regulation NOX3 ARSA 22306536 2565241 also *suppressed* the expression of [NADPH oxidase] subunits ( p22(phox) , p47(phox) , p67(phox) , NOX2 and NOX4 ) and ROS generation . Negative_regulation NOX3 ARSA 22306536 2565247 These observations suggest that *inhibits* Ang II-induced [NADPH oxidase] expression , NF-?B activation and AT1R transcription in cardiac fibroblasts , and fibroblast proliferation and collagen expression . Negative_regulation NOX3 MAP2K6 17854274 1810466 Constitutively active and wild-type enhanced Rac-GTPase activity in vitro , and their overexpression *inhibited* PMA induced [NADPH oxidase] activation in RAW cells . Negative_regulation NOX3 MMP28 17543193 1668530 The endothelial cell NADPH oxidase and endothelial cell activities are *required* for VCAM-1 dependent lymphocyte migration as determined by scavenging of ROS , by pharmacologic or antisense inhibition of [NADPH oxidase] and by pharmacologic inhibition of endothelial cell MMPs . Negative_regulation NOX3 MMP7 17543193 1668545 The endothelial cell NADPH oxidase and endothelial cell activities are *required* for VCAM-1 dependent lymphocyte migration as determined by scavenging of ROS , by pharmacologic or antisense inhibition of [NADPH oxidase] and by pharmacologic inhibition of endothelial cell MMPs . Negative_regulation NOX3 TNF 19450605 2096927 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated [gp91(phox)-NADPH oxidase] expression and activity , decreased phosphorylation of ERK1/2/p38 MAPK and *inhibited* cardiac expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation NOX4 ARSA 22306536 2565224 Recent studies show that not only blocks cyclooxygenase , but also *inhibits* [NADPH oxidase] and resultant reactive oxygen species ( ROS ) generation , a pathway that underlies pathogenesis of several ailments , including hypertension and tissue remodeling after injury . Negative_regulation NOX4 ARSA 22306536 2565232 In this study , we examined if would *inhibit* [NADPH oxidase] activation , upregulation of AT1R transcription , and subsequent collagen generation in mouse cardiac fibroblasts challenged with Ang II . Negative_regulation NOX4 ARSA 22306536 2565242 also *suppressed* the expression of [NADPH oxidase] subunits ( p22(phox) , p47(phox) , p67(phox) , NOX2 and NOX4 ) and ROS generation . Negative_regulation NOX4 ARSA 22306536 2565248 These observations suggest that *inhibits* Ang II-induced [NADPH oxidase] expression , NF-?B activation and AT1R transcription in cardiac fibroblasts , and fibroblast proliferation and collagen expression . Negative_regulation NOX4 MAP2K6 17854274 1810470 Constitutively active and wild-type enhanced Rac-GTPase activity in vitro , and their overexpression *inhibited* PMA induced [NADPH oxidase] activation in RAW cells . Negative_regulation NOX4 MMP28 17543193 1668552 The endothelial cell NADPH oxidase and endothelial cell activities are *required* for VCAM-1 dependent lymphocyte migration as determined by scavenging of ROS , by pharmacologic or antisense inhibition of [NADPH oxidase] and by pharmacologic inhibition of endothelial cell MMPs . Negative_regulation NOX4 MMP7 17543193 1668567 The endothelial cell NADPH oxidase and endothelial cell activities are *required* for VCAM-1 dependent lymphocyte migration as determined by scavenging of ROS , by pharmacologic or antisense inhibition of [NADPH oxidase] and by pharmacologic inhibition of endothelial cell MMPs . Negative_regulation NOX4 TNF 19450605 2096928 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated [gp91(phox)-NADPH oxidase] expression and activity , decreased phosphorylation of ERK1/2/p38 MAPK and *inhibited* cardiac expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation NOX5 ARSA 22306536 2565221 Recent studies show that not only blocks cyclooxygenase , but also *inhibits* [NADPH oxidase] and resultant reactive oxygen species ( ROS ) generation , a pathway that underlies pathogenesis of several ailments , including hypertension and tissue remodeling after injury . Negative_regulation NOX5 ARSA 22306536 2565229 In this study , we examined if would *inhibit* [NADPH oxidase] activation , upregulation of AT1R transcription , and subsequent collagen generation in mouse cardiac fibroblasts challenged with Ang II . Negative_regulation NOX5 ARSA 22306536 2565239 also *suppressed* the expression of [NADPH oxidase] subunits ( p22(phox) , p47(phox) , p67(phox) , NOX2 and NOX4 ) and ROS generation . Negative_regulation NOX5 ARSA 22306536 2565244 These observations suggest that *inhibits* Ang II-induced [NADPH oxidase] expression , NF-?B activation and AT1R transcription in cardiac fibroblasts , and fibroblast proliferation and collagen expression . Negative_regulation NOX5 MAP2K6 17854274 1810458 Constitutively active and wild-type enhanced Rac-GTPase activity in vitro , and their overexpression *inhibited* PMA induced [NADPH oxidase] activation in RAW cells . Negative_regulation NOX5 MMP28 17543193 1668418 The endothelial cell NADPH oxidase and endothelial cell activities are *required* for VCAM-1 dependent lymphocyte migration as determined by scavenging of ROS , by pharmacologic or antisense inhibition of [NADPH oxidase] and by pharmacologic inhibition of endothelial cell MMPs . Negative_regulation NOX5 MMP7 17543193 1668433 The endothelial cell NADPH oxidase and endothelial cell activities are *required* for VCAM-1 dependent lymphocyte migration as determined by scavenging of ROS , by pharmacologic or antisense inhibition of [NADPH oxidase] and by pharmacologic inhibition of endothelial cell MMPs . Negative_regulation NOX5 TNF 19450605 2096911 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated [gp91(phox)-NADPH oxidase] expression and activity , decreased phosphorylation of ERK1/2/p38 MAPK and *inhibited* cardiac expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation NPC2 TNF 23666609 2827830 In vitro studies showed that *reduces* intracellular protein levels of CtB , CtL , and [NPC2] , but increases their secretion in 3T3-L1 adipocytes . Negative_regulation NPEPPS TNF 14715080 1225540 We observed that activation of NF-kappaB by ( tumour necrosis factor alpha ) *inhibited* both basal and androgen stimulated [PSA] expression , and that this down-regulation occurred at the promoter level , as confirmed by the super-repressor IkappaBalpha ( S32A/S36A ) , a dominant negative inhibitor of NF-kappaB . Negative_regulation NPM1 TGM2 18851895 2021365 Taking these results together , it can be concluded that *inhibits* accumulation of cytosolic [nucleophosmin] through polymerization , which results in drug resistance in cancer cells . Negative_regulation NPPA HBEGF 11457715 838194 Epidermal growth factor (EGF) and , but not platelet derived growth factor or insulin-like growth factor I , *inhibited* ( 125 ) [I-ANP] binding to ND-NOD and D-NOD mesangial cells , particularly in the latter . Negative_regulation NPPA IL1B 8396869 230338 To assess the central *role* of in the release of ACTH , vasopressin ( AVP ) and [atrial natriuretic peptide (ANP)] and in the regulation of blood pressure and thermogenesis , 3 ng ( 0.173 pM ) x 100-1 x BW-1 ( LIL ) , 30 ng ( 1.73 pM ) x 100g-1 x BW-1 ( MIL ) , and 150 ng ( 8.63 pM ) x 100g-1 x BW-1 ( HIL ) of human IL-1 beta dissolved in sterile saline were injected intracerebroventricularly to conscious rats . Negative_regulation NPR1 EDN2 12623978 1066530 *inhibits* [NPR-A] and stimulates eNOS gene expression in rat IMCD cells . Negative_regulation NPR2 CLU 24671452 2949155 The purpose of this study was to investigate whether the therapeutic activity of [gemcitabine (GCB)] in hepatocellular carcinoma ( HCC ) could be *increased* by the down-regulation of secretory ( sCLU ) , a glycoprotein that is considered to play a cytoprotective role in the resistance to chemotherapy . Negative_regulation NPY TNF 10704730 672998 ) , which are elevated in cancer patients , can *attenuate* [NPY] release from hypothalamic slices in vitro . Negative_regulation NPY TNF 23623189 2795465 Our results demonstrate for the first time that [NPY] can directly *induce* active HMGB1 release and cytoplasmic translocation , while the production of , IL-1ß and IL-6 is not affected . Negative_regulation NPY4R PPP1R1A 12514122 1063789 The *inhibits* [phosphatase type-1 (PP1)] only when phosphorylated by protein kinase A and could play a pivotal role in the phosphorylation/dephosphorylation balance . Negative_regulation NPY4R SMN2 22454514 2637075 Notably , deficiency in SMA *leads* to the aberrant subcellular localization of Gemin8 and [PP1?] in the atrophic skeletal muscles , suggesting that the function of PP1? is likely to be affected in disease . Negative_regulation NPY4R TNF 12850280 1109347 okadaic acid ( PP-2A inhibitor ) was ineffective , while ( [PP-1] *inhibitor* ) blocked the action of insulin and reduced that of GLP-1 ; Negative_regulation NQO1 TNF 17588258 1786272 Both and LPS *repressed* the beta-naphthoflavone ( betaNF ) -mediated induction of Cyp1a1 and [Nqo1] at mRNA and activity levels . Negative_regulation NR0B2 IL1B 15550563 1380574 However , CDCA induced , but *reduced* , [small heterodimer partner (SHP)] mRNA expression . Negative_regulation NR1I2 CAPN8 18544536 1940507 The decrease in [SXR] level was due to an enhanced rate of protein degradation and was *dependent* on activity , as opposed to rexinoid induced RXR degradation , which is mediated via the proteasome . Negative_regulation NR3C2 HSD11B2 23042946 2698571 Furthermore , inhibition of activity by 18ß-glycyrrhetinic acid *resulted* in elevated whole-body cortisol levels and preoptic area mRNA abundance of corticotropin releasing factor and [mineralocorticoid receptor] . Negative_regulation NR3C2 ITGAL 11834839 911156 These LFA-1 antagonists bound , blocked binding of ICAM-1 , and *inhibited* a [mixed lymphocyte reaction (MLR)] with potency significantly greater than that of cyclosporine A . Negative_regulation NR3C2 ITGAL 2966435 91720 The CD5- , and CD11c-reactive MoAb significantly *inhibited* the primary [MLR] ( inhibition = 25 % , P less than or equal to 0.01 ; 48 % , P less than or equal to 0.01 and 13 % , P less than or equal to 0.05 , respectively ) but these MoAb did not inhibit the primed lymphocyte reaction ( PLR ) . Negative_regulation NR3C2 PECAM1 7858258 294887 The peptide strongly *inhibited* the [MLR] . Negative_regulation NR3C2 PECAM1 9028970 413565 In vitro , peptide *inhibited* the [MLR] across several major and minor histocompatibility differences in a specific and dose dependent fashion , similar to the results observed in the human system . Negative_regulation NR4A1 EPHB2 22186412 2543387 These results further clarify the *role* of and PKC signaling in regulation of the GnRH induced immediate early gene program as well as GnRH induced transcription stimulating activity of [Nur77] in the gonadotrope and shed new light on the complex functional organization of this signaling pathway in the pituitary gonadotrope . Negative_regulation NR4A2 EPHB2 15106839 1240579 Differential *role* of in cAMP induced [Nurr1] expression in N2A and C6 cells . Negative_regulation NR4A2 MAP2K6 19418629 2075918 In accordance with earlier findings , in H295R cells inhibition *increased* the expression of NR4A1 , [NR4A2] and CYP11B2 genes , however , it decreased the Ang II-induced gene expression levels , suggesting that ERK activation has a role in control of expression of these genes . Negative_regulation NR4A2 TNF 17671512 1848666 Increased expression of the [orphan nuclear receptor NURR1] in psoriasis and modulation *following* inhibition . Negative_regulation NR5A1 EPHB2 11410589 849744 We demonstrate that cyclic AMP induced steroid synthesis is dependent upon the phosphorylation and activation of ERKs and that activation *results* in enhanced phosphorylation of [SF-1] and increased steroid production through increased transcription of the StAR gene . Negative_regulation NRARP NOTCH1 11783997 891467 Thus , [Nrarp] transcript levels are *regulated* by the level of signaling in both cultured cell lines and mouse embryos . Negative_regulation NRARP NOTCH3 20960513 2357383 Because overexpression of *activated* the expression of [Nrarp] , a negative feedback regulator of Notch signaling , Notch3 might act as a Notch1 repressor by activating Nrarp . Negative_regulation NRAS EPHB2 10978313 751955 Whereas the essential *roles* of and JNK in [Ras] signaling has been established , the contribution of p38 remains unclear . Negative_regulation NRAS EPHB2 11585923 866388 We find that unlike other receptor tyrosine kinases , *induces* a pronounced downregulation of GTP bound [Ras] and consequently of the extracellular signal regulated kinase ( ERK ) mitogen activated protein kinase (MAPK) pathway . Negative_regulation NRAS EPHB2 11874466 918780 Further evidence for differential regulation of RAS and ERK is provided by the observations that TPO , which activates RAS but not protein kinase C , does not activate , and that the inhibitor of SRC kinases PP1 *inhibits* activation of [RAS] but not ERK2 in response to thrombin . Negative_regulation NRAS EPHB2 14660603 1202132 However , when COS-1 cells were transfected with Ras complexed to CD8 , plasma membrane localization of [Ras] was unaffected by AFC , yet EGF stimulated activation was *inhibited* by AFC . Negative_regulation NRAS EPHB2 15070811 1265767 Specific IL-1 receptor antagonism and selective kinase or upstream [Ras] *inhibition* prevented these increases , whereas PKC inhibition did not . Negative_regulation NRAS EPHB2 16978937 1673657 Matrix mineralization by preosteocytic MLO-A5 cells and osteoblastic MC3T3-E1 cells was increased by either PD98059 Mek inhibitor treatment or adenovirus vector mediated dominant negative [Ras] ( Ras ( DN ) ) expression and was *suppressed* by activation by platelet derived growth factor ( PDGF ) treatment or constitutively active Mek1 ( Mek ( CA ) ) expression . Negative_regulation NRAS EPHB2 22371971 2561717 Inhibition of calcineurin further reduced the phosphorylation of and AKT ( at thr 308 ) and *inhibited* the activation of [Ras] , but inhibitors of MAPK or PI3K signaling did not affect the circadian rhythm of calcineurin activity . Negative_regulation NRAS EPHB2 22425622 2612679 DGKa knockdown impaired MEK and phosphorylation , but did not *inhibit* [Ras] activation in HCC cells . Negative_regulation NRAS EPHB2 24576830 2929524 In these cell lines , the MEK inhibitor PD0325901 inhibited phosphorylation , but also relieved feedback *inhibition* of [RAS] , resulting in induction of pMEK and a rapid rebound in ERK signaling . Negative_regulation NRAS FHL1 23456229 2781809 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Negative_regulation NRAS MAP2K6 10978313 751970 Moreover , the constitutive p38 activator also *suppressed* [Ras] activity in a p38 dependent manner whereas arsenite , a potent chemical inducer of p38 , inhibited proliferation only in a tumor cell line that required Ras activity . Negative_regulation NRAS MAP2K6 12364324 1019122 GLP1 stimulated activation of Erk is blocked by inhibitors of , but GLP1 does not *induce* the activation of A-Raf , B-Raf , C-Raf , or [Ras] . Negative_regulation NRAS MAP2K6 12411397 1010735 PE and ET-1 do not activate protein kinase B but *stimulate* [Ras] and Erk , and their ability to activate protein synthesis was blocked by inhibition of Ras or and by rapamycin , which inhibits mTOR ( mammalian target of rapamycin ) . Negative_regulation NRAS MAP2K6 22425622 2612685 DGKa knockdown impaired and ERK phosphorylation , but did not *inhibit* [Ras] activation in HCC cells . Negative_regulation NRAS MUC16 17268066 1691615 Expression of [RAS1mRNA] in C. albicans was *inhibited* by . Negative_regulation NRAS PLAU 16826166 1638593 Functional blockade of or inhibition of p70S6 kinase , but not *inhibition* of [Ras/ERK] signaling , suppresses this GM3 induced stimulation of cell proliferation . Negative_regulation NRAS TNF 12526099 1028255 These results indicate that [RAs] attenuate iNOS expression reversibly in TNF stimulated 3T3-L1 adipocytes , and that the induced LPL suppression is not the *result* of NO overproduction . Negative_regulation NRAS TNF 21938476 2532757 With 4-MC pretreatment to hyperglycemic rats the following results were noted : ( i ) Decrease in pancreatic NGF level was blocked , ( ii ) Increase in pancreatic level and the number of TNF-a ( + ) beta cell in the islets were prevented , ( iii ) *Increase* in the number of ß cell synthhesized apoptotic [Ras] effectors that RASSF1 and NORE1 was blocked , ( iv ) While pancreatic lipid peroxidation level decreased , antioxidant molecule glutathione and antioxidant enzymes glutathione peroxidase , catalase and superoxide dismutase activities increased , ( v ) Pancreatic caspase-3 activity and the number of cleaved caspase-3 ( + ) ß cells were decreased . Negative_regulation NRD1 HBEGF 12095415 984463 The metalloendopeptidase [nardilysin] ( NRDc ) is potently *inhibited* by heparin binding epidermal growth factor-like growth factor ( ) . Negative_regulation NRF1 PGC 23159434 2729675 Furthermore , the overexpression of induced by transfection largely *increased* the expression levels of [NRF-1] and TFAM and significantly decreased the expression level of NF-?B in the cell senescence model . Negative_regulation NRL NR2F1 19766631 2183497 Using the Y79 retinoblastoma cell line , we observed that and -TFII *suppressed* the transcriptional activation of the [Nrl] gene . Negative_regulation NRP1 TNF 15555625 1340073 significantly *reduced* protein levels of VEGFR-2 , VEGFR-3 , and [NRP-1] by 59 , 35 , and 22 % , respectively . Negative_regulation NRROS TLR7 24550525 2942625 Notably , [LRRC33] expression could be *down-regulated* by ligands LPS , poly I:C , or PGN through H3K4me3 and H3K27me3 modification . Negative_regulation NT5E AP5B1 17619122 1787014 MK-801 and *prevented* the L- and D-Asp evoked activation of [ecto-5'-nucleotidase] . Negative_regulation NT5E C5 8348695 227041 [Ecto-5'-nucleotidase] activity of polymorphonuclear leukocytes was *attenuated* by both FMLP and ( 22.7 +/- 3.6 vs 9.7 +/- 2.6 nmol/min per 10 ( 7 ) cells at 10 ( -6 ) M FMLP , P < .05 ; 21.5 +/- 2.2 vs 10.2 +/- 1.2 nmol/min per 10 ( 7 ) cells at 5 x 10 ( -7 ) g/mL complement C5a , P < .001 ) , whereas cytosolic 5'-nucleotidase activity was not affected by either FMLP or complement C5a . Negative_regulation NT5E ESR1 14760094 1206878 *Role* of in the regulation of [ecto-5'-nucleotidase] and adenosine in breast cancer . Negative_regulation NT5E GPI 18272749 1896147 Inhibition of the or the presence of nonhydrolyzable substrate analogs of Gce1 and CD73 interfered with the palmitate- , H ( 2 ) O ( 2 ) - , and glimepiride *induced* 1 ) lipolytic cleavage of Gce1 and [CD73] , 2 ) translocation of their GPI anchored versions from DIGs to LDs , 3 ) up-regulation of cAMP degradation , and 4 ) inhibition of lipolysis . Negative_regulation NT5E HIF1A 12370277 995689 Examination of the CD73 gene promoter identified at least one binding site for hypoxia-inducible factor-1 (HIF-1) and inhibition of expression by antisense oligonucleotides *resulted* in significant inhibition of hypoxia-inducible [CD73] expression . Negative_regulation NT5E HMGB1 18715162 1961569 MSCs exposed to HMGB1 were negative for CD31 , CD45 , CD80 , and HLA-DR , and displayed equal levels of [CD73] , CD166 , and HLA-ABC compared with their counterparts , but profoundly *suppressed* MSC proliferation in a dose dependent manner as evaluated by carboxyfluorescein diacetate succinmidyl ester dye dilution assay . Negative_regulation NT5E HSPG2 18272749 1896148 Inhibition of the or the presence of nonhydrolyzable substrate analogs of Gce1 and CD73 interfered with the palmitate- , H ( 2 ) O ( 2 ) - , and glimepiride *induced* 1 ) lipolytic cleavage of Gce1 and [CD73] , 2 ) translocation of their GPI anchored versions from DIGs to LDs , 3 ) up-regulation of cAMP degradation , and 4 ) inhibition of lipolysis . Negative_regulation NT5E PRKCA 9345290 459366 *Role* of in activation of [ecto-5'-nucleotidase] in the preconditioned canine myocardium . Negative_regulation NT5E PTN 1644065 194858 Furthermore , , PTN124 , and PTN514 *reduced* the [5'-nucleotidase] AMPase activity in contrast to PTN63 having no inhibitory effect . Negative_regulation NT5E SOD1 8186402 242839 Therefore , we hypothesized that reduces generation of oxygen derived free radicals during ischemia and reperfusion and *attenuates* the degradation of [ecto-5'-nucleotidase] . Negative_regulation NT5E SOD2 8186402 242840 Therefore , we hypothesized that reduces generation of oxygen derived free radicals during ischemia and reperfusion and *attenuates* the degradation of [ecto-5'-nucleotidase] . Negative_regulation NT5E SOD3 8186402 242841 Therefore , we hypothesized that reduces generation of oxygen derived free radicals during ischemia and reperfusion and *attenuates* the degradation of [ecto-5'-nucleotidase] . Negative_regulation NT5E STAT3 22406269 2572628 supported whereas Gfi-1 *repressed* CD39 and [CD73] expression by binding to their promoters . Negative_regulation NT5E TNC 16718268 1565262 As ConA induced clustering may reflect the interactions of membrane proteins with extracellular matrix , we also analysed the effect of several extracellular matrix proteins on the in-situ activity of ecto-5'-nucleotidase in WM9 cells and found that strongly *inhibited* [ecto-5'-nucleotidase] activity and adenosine generation from AMP . Negative_regulation NTF3 CAPN8 15264225 1275183 NGF acts via p75 low-affinity [neurotrophin] receptor and *inhibition* to reduce UV neurotoxicity . Negative_regulation NTF4 CAPN8 15264225 1275197 NGF acts via p75 low-affinity [neurotrophin] receptor and *inhibition* to reduce UV neurotoxicity . Negative_regulation NTN1 ITGB2 8097379 217631 In light of the ability of CD18 integrins to participate in leukocyte adherence ( and thereby migration ) , we examined the *role* of the integrin in [NTN] using OX42 , a monoclonal antibody directed against rat CD11b . Negative_regulation NTN1 UNC5B 21820492 2485198 Quantitative reverse transcription polymerase chain reaction ( qPCR ) and Western blot analysis revealed that treadmill exercise *enhanced* [netrin-1] and DCC expression , while it suppressed expression in rat peri-ischemic brain area , especially at day 14 and 28 after MCAO ( n = 4 , P < 0.05 or P < 0.01 ) . Negative_regulation NTN1 UNC5B 23651544 2805303 The receptor *induces* apoptosis in the absence of its cognate ligand [netrin-1] . Negative_regulation NTN3 ITGB2 8097379 217633 In light of the ability of CD18 integrins to participate in leukocyte adherence ( and thereby migration ) , we examined the *role* of the integrin in [NTN] using OX42 , a monoclonal antibody directed against rat CD11b . Negative_regulation NTN4 ITGB2 8097379 217627 In light of the ability of CD18 integrins to participate in leukocyte adherence ( and thereby migration ) , we examined the *role* of the integrin in [NTN] using OX42 , a monoclonal antibody directed against rat CD11b . Negative_regulation NTN5 ITGB2 8097379 217629 In light of the ability of CD18 integrins to participate in leukocyte adherence ( and thereby migration ) , we examined the *role* of the integrin in [NTN] using OX42 , a monoclonal antibody directed against rat CD11b . Negative_regulation NTRK1 NGFR 7815475 285262 It was found that NGF internalization was neither prevented by blocking [p140trkA] activity using the protein kinase inhibitors methylthioadenosine , staurosporine , and K-252a , nor by *inhibiting* NGF binding to with antibodies . Negative_regulation NTSR1 EPHB2 20663927 2305273 The purpose of our current study was to determine : ( a ) whether HDACi alters NTR1 expression and function , and ( b ) the *role* of in [NTR1] regulation . Negative_regulation NUDC TNF 22025632 2508088 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation NUP153 IFI27 12490316 1033142 To clarify the *roles* of and c-myc in [nasopharyngeal carcinoma (NPC)] , we used immunohistochemical studies to examine the expression of p27 and c-myc proteins in 69 patients with NPC . Negative_regulation NUP210 IFI27 12490316 1033141 To clarify the *roles* of and c-myc in [nasopharyngeal carcinoma (NPC)] , we used immunohistochemical studies to examine the expression of p27 and c-myc proteins in 69 patients with NPC . Negative_regulation NUP214 IFI27 12490316 1033143 To clarify the *roles* of and c-myc in [nasopharyngeal carcinoma (NPC)] , we used immunohistochemical studies to examine the expression of p27 and c-myc proteins in 69 patients with NPC . Negative_regulation NUP43 EPHB2 11390379 849512 Co-expression of the CaR with a peptide derived from the region of the CaR C terminus that interacts with filamin reduced the ability of the CaR to activate [p42ERK] in a dose dependent manner , but did not *inhibit* the ability of the ET ( A ) receptor to activate . Negative_regulation NUP43 EPHB2 21518868 2428882 EGF activates NF-?B and *stimulates* phosphorylation of FER , EGF receptor (EGFR) , and ERK [p42/p44] , and decreased expression of FER or inhibition of phosphorylation inhibits the EGF induced activation of NF-?B . Negative_regulation NUP43 IL1B 12139924 969350 Regarding intracellular signaling , activated the p38 mitogen activated protein kinase (MAPK) but not the p42/p44 MAPK and , when combined with growth factors , intensified p38 activation but *inhibited* the growth-factor induced [p42/p44] activation . Negative_regulation NUP43 MAP2K6 11834245 910352 Furthermore , ( MEK)-1-specific inhibitor , 2- ( 2-amino-3-methoxyphenyl ) -4H-1-benzopyran-4-one ( PD 98059 ) , *blocked* the lipopolysaccharide induced [p44/42] ERK activation and PDGF production . Negative_regulation NUP43 TNF 10329978 613988 Furthermore , *repressed* insulin induced [p42] ( MAPK ) and p44 ( MAPK ) tyrosine phosphorylation by 81 % ( P < 0.01 ) . Negative_regulation NUP43 TNF 15187147 1256438 Disruption of lipid rafts by cholesterol depletion prevented the dependent recruitment of TNF-R1 to lipid rafts and *inhibited* the activation of [p42] ( mapk/erk2 ) , while the activation of NF-kappaB was unaffected . Negative_regulation NUP43 TNF 9370349 464155 A comparable mediated *inhibition* of [p42/44] mitogen activated protein (MAP) kinase activity was observed in 10 nM EGF stimulated cells . Negative_regulation NUP62 IFI27 12490316 1033144 To clarify the *roles* of and c-myc in [nasopharyngeal carcinoma (NPC)] , we used immunohistochemical studies to examine the expression of p27 and c-myc proteins in 69 patients with NPC . Negative_regulation OAF IL1B 2143127 137582 [OAF] activity was totally *inhibited* by . Negative_regulation OATP1 TNF 15860642 1464964 *induces* a sustained decrease in Ntcp , [Oatp1/Oatp1a1] , and Bsep mRNA expression but exerts only transient [ multidrug resistance associated protein 2 ( Mrp2 ) ] or no effects ( Mrp3 ) on Mrps . Negative_regulation OATP1 TNF 19074973 2035849 and IL-6 concomitantly *reduced* NTCP and [OATP1B1] protein expression and NTCP , OATP , and OCT1 transport activities . Negative_regulation OCLN IL1B 18848892 1994234 In the cultured leptomeningeal cells , and PGE ( 2 ) *caused* a marked loss of [occludin] and ZO-1 , respectively . Negative_regulation OCLN PLAT 24045404 2888219 Progesterone treatment significantly prevented *induced* decrease in TEER and expression of [occludin] and claudin-5 , and attenuated VEGF levels in culture media subjected to hypoxia . Negative_regulation OCLN TNF 11432982 832075 Removal of from astrocytes *restored* the basal level of [occludin] . Negative_regulation OCLN TNF 12488366 1033081 also *inhibited* the timely induction of [occludin] , which is known to associate with the Sertoli cell TJ-barrier assembly . Negative_regulation OCLN TNF 19195861 2202555 HG and induced the expression of cell adhesion molecules and *reduced* that of [occludin] in EC . Negative_regulation OCLN TNF 23538493 2788580 In addition , *induced* a downregulation of claudin-1 , claudin-2 , claudin-4 , and [occludin] as well as activation of phosphatidylinositol 3-kinase signaling in T-84 but not Caco-2 cells , which was reversed by adalimumab . Negative_regulation ODC1 KLF9 12297499 1012671 Gut enriched *represses* [ornithine decarboxylase] gene expression and functions as checkpoint regulator in colonic cancer cells . Negative_regulation ODC1 TGM2 10674181 578781 NA reduced tumor growth , *inhibited* the 12-O-tetradecanoylphorbol-13-acetate ( TPA ) induced [ornithine decarboxylase] activity , but induced the activity which was inhibited by TPA under different experimental conditions . Negative_regulation ODC1 TGM2 6125941 22215 Retinoids increase activity and *inhibit* [ornithine decarboxylase] activity in Chinese hamster ovary cells and in melanoma cells stimulated to differentiate . Negative_regulation ODC1 TGM2 7636843 317469 The biological activities associated with the RAR and RXR receptors were examined by testing representative examples with different receptor activation profiles for their ability to induce ( Tgase ) activity in a human promyelocytic leukemia cell line ( HL-60 cdm-1 ) and to *inhibit* tumor-promoter induced [ornithine decarboxylase (ODC)] activity in hairless mouse skin . Negative_regulation ODC1 TNF 10199820 605365 and IFN-gamma induction of NO generation *resulted* in suppressed [ODC] activity , an effect prevented by the inducible NOS inhibitor L-N6- ( 1-iminoethyl ) lysine ( L-NIL ) . Negative_regulation OLFM4 MMP9 23161172 2707585 Moreover , forced expression of *attenuated* the inhibitory activity of [OLFM4] on migration and invasiveness . Negative_regulation OLR1 FAS 21078775 2376721 Unsaturated *prevent* palmitate induced [LOX-1] induction via inhibition of ER stress in macrophages . Negative_regulation OLR1 MAP2K6 15380451 1298438 Both and p38 mitogen activated protein kinase (MAPK) inhibitors significantly *blocked* [LOX-1] upregulation induced by HB-EGF . Negative_regulation OPA1 ADRB2 8388911 220307 These findings illustrate an important functional difference between the in vivo macrophages and differentiated U937 cells because stimulation does not *inhibit* [mediator] release from macrophages . Negative_regulation OPA1 F2R 9141614 428452 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Negative_regulation OPA1 FOXO1 22342903 2668569 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by PKA or silencing [mediator] of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation OPA1 HSD11B2 20544861 2271824 We propose that <11 beta HSD-1> may provide microglia with an intrinsic mechanism to autoregulate and *inhibit* proinflammatory [mediator] production through CORT formation . Negative_regulation OPA1 TNF 23453807 2756103 Notably , in parkin-deficient cells linear ubiquitination of NEMO , activation of NF-?B , and upregulation of [OPA1] are significantly reduced in *response* to stimulation , supporting the physiological relevance of parkin in regulating this antiapoptotic pathway . Negative_regulation OPN1LW MAP2K6 21388951 2421033 The levels of Cbp expression were inversely correlated with the activity of MEK and Akt , and [Cbp] down-regulation was *suppressed* by inhibiting and PI3K . Negative_regulation OPN1LW MAP2K6 21388951 2421044 Furthermore , the inhibition of or HDAC *restored* [Cbp] expression in human cancer cells harboring Cbp down-regulation through promoter hypomethylation . Negative_regulation OPN1LW TNF 23297421 2746120 , acting via NF-?B , did not change the levels of CREB , Sp1 , or Egr-1 binding to the Gas promoter , but it *induced* a significant reduction in the level of [CBP] . Negative_regulation OPN3 NR2F1 19812316 2148672 Through gain- and loss-of-function analyses , we found that both and COUP-TFII are *required* to suppress [S-opsin] expression in the dorsal retina but that only COUP-TFI plays an essential role in suppressing M-opsin expression in the ventral retina . Negative_regulation OPN4 NR2F1 19812316 2148674 Through gain- and loss-of-function analyses , we found that both and COUP-TFII are *required* to suppress [S-opsin] expression in the dorsal retina but that only COUP-TFI plays an essential role in suppressing M-opsin expression in the ventral retina . Negative_regulation OPN5 NR2F1 19812316 2148676 Through gain- and loss-of-function analyses , we found that both and COUP-TFII are *required* to suppress [S-opsin] expression in the dorsal retina but that only COUP-TFI plays an essential role in suppressing M-opsin expression in the ventral retina . Negative_regulation OPRM1 GPR115 10698001 671451 To investigate the functional *role* of in homologous desensitization of the [mu-opioid receptor] , human embryonic kidney (HEK) 293 cells , which express a significant level of GRK2 , were stably transfected with the cDNA encoding the rat mu-opioid receptor . Negative_regulation OPRM1 GPR132 10698001 671440 To investigate the functional *role* of in homologous desensitization of the [mu-opioid receptor] , human embryonic kidney (HEK) 293 cells , which express a significant level of GRK2 , were stably transfected with the cDNA encoding the rat mu-opioid receptor . Negative_regulation OPRM1 GPR87 10698001 671520 To investigate the functional *role* of in homologous desensitization of the [mu-opioid receptor] , human embryonic kidney (HEK) 293 cells , which express a significant level of GRK2 , were stably transfected with the cDNA encoding the rat mu-opioid receptor . Negative_regulation OSM IFI27 10951574 723747 Inhibition of MEK activation completely abrogated [OSM] and IL-6 *induced* p27kip1 accumulation , while expression of dominant negative STAT5 decreased the OSM and IL-6 mediated inhibition of DNA-synthesis and partially inhibited accumulation . Negative_regulation OSM MAP2K6 17226768 1771588 Whereas , the JAK3 inhibitor , WHI-P131 , and the inhibitor , U0126 , *had* no effects on the anti-adipogenic activity of [OSM] . Negative_regulation OSM PLAT 9863709 556133 On human umbilical vein endothelial cells , [oncostatin M] *induced* an increase in PAI-1 and a decrease in secretion , which could explain the thrombogenicity of oncostatin M on large vessels . Negative_regulation OSR1 PDC 21209911 2359422 This downregulatory effect was abolished when the [oxygen dependent domain (ODD)] of HIF-1a ( HIF-1a-?ODD , the domain responsible for HIF-1a degradation ) was experimentally deleted or when the activity of HIF-1a or the 26S proteasomal complex was *inhibited* , indicating that the 1 , 9 PA downregulates HIF-1a by promoting PHD dependent HIF-1a degradation . Negative_regulation OSR1 PDC 23456821 2799481 Surprisingly , inhibitors and proteasome inhibitors do not *stabilize* [ODD-luc] in OGD . Negative_regulation OSR1 PRKAA1 24808538 2944748 In conclusion , this study identifies increased phosphorylation of NKCC2 on S126 as a hitherto unrecognized mediator of enhanced Na ( + ) reabsorption in obesity and identifies a new *role* for in regulating the activity of [SPAK/OSR1] . Negative_regulation OSR1 PRKAA2 24808538 2944749 In conclusion , this study identifies increased phosphorylation of NKCC2 on S126 as a hitherto unrecognized mediator of enhanced Na ( + ) reabsorption in obesity and identifies a new *role* for in regulating the activity of [SPAK/OSR1] . Negative_regulation OSR1 PRKAB1 24808538 2944750 In conclusion , this study identifies increased phosphorylation of NKCC2 on S126 as a hitherto unrecognized mediator of enhanced Na ( + ) reabsorption in obesity and identifies a new *role* for in regulating the activity of [SPAK/OSR1] . Negative_regulation OSR1 PRKAB2 24808538 2944751 In conclusion , this study identifies increased phosphorylation of NKCC2 on S126 as a hitherto unrecognized mediator of enhanced Na ( + ) reabsorption in obesity and identifies a new *role* for in regulating the activity of [SPAK/OSR1] . Negative_regulation OSR1 PRKAG1 24808538 2944752 In conclusion , this study identifies increased phosphorylation of NKCC2 on S126 as a hitherto unrecognized mediator of enhanced Na ( + ) reabsorption in obesity and identifies a new *role* for in regulating the activity of [SPAK/OSR1] . Negative_regulation OSR1 PRKAG2 24808538 2944753 In conclusion , this study identifies increased phosphorylation of NKCC2 on S126 as a hitherto unrecognized mediator of enhanced Na ( + ) reabsorption in obesity and identifies a new *role* for in regulating the activity of [SPAK/OSR1] . Negative_regulation OSTN FOXO1 17950246 1820027 *represses* expression of [musclin] , a skeletal muscle derived secretory factor . Negative_regulation OXA1L TF 19320475 2073794 In the *presence* of both and IgG , curcumin continues to undergo rapid hydrolysis but this reaction is suppressed by the presence of either [HSA] or fibrinogen with an impressive yield of approximately 95 % . Negative_regulation OXTR CEBPA 15494465 1359494 Overexpression of , but not AP-1 , *increased* [OTR] promoter activity . Negative_regulation OXTR PRDX2 22999795 2720117 Both and andrographolide dose-dependently *inhibit* [OTR] expression in MSMC . Negative_regulation OXTR RELN 15949229 1421223 Availability of the reelin haploinsufficient ( +/- ) reeler mouse ( HRM ) provides a model for examining the *role* of in the development of the OT system and especially in the expression of the [OT receptor (OTR)] . Negative_regulation OXTR ZEB1 21079000 2354831 Excitingly , we observed that and ZEB2 *inhibit* expression of the contraction associated genes , [oxytocin receptor] and connexin-43 , and block oxytocin induced contractility in human myometrial cells . Negative_regulation OXTR ZEB2 21079000 2354832 Excitingly , we observed that ZEB1 and *inhibit* expression of the contraction associated genes , [oxytocin receptor] and connexin-43 , and block oxytocin induced contractility in human myometrial cells . Negative_regulation P4HB TNF 8691130 372698 However , enhanced in vitro baboon thymocyte proliferation to concanavalin A , and infusion of p75TNF *resulted* in increased soluble [p55] and p75 receptor plasma concentrations . Negative_regulation PADI3 NFYA 16671893 1583535 and Sp1/Sp3 are *involved* in the transcriptional regulation of the peptidylarginine deiminase type III gene ( [PADI3] ) in human keratinocytes . Negative_regulation PADI3 NFYB 16671893 1583536 and Sp1/Sp3 are *involved* in the transcriptional regulation of the peptidylarginine deiminase type III gene ( [PADI3] ) in human keratinocytes . Negative_regulation PADI3 NFYC 16671893 1583537 and Sp1/Sp3 are *involved* in the transcriptional regulation of the peptidylarginine deiminase type III gene ( [PADI3] ) in human keratinocytes . Negative_regulation PADI3 SP1 16671893 1583533 NF-Y and are *involved* in the transcriptional regulation of the peptidylarginine deiminase type III gene ( [PADI3] ) in human keratinocytes . Negative_regulation PADI3 SP3 16671893 1583534 NF-Y and are *involved* in the transcriptional regulation of the peptidylarginine deiminase type III gene ( [PADI3] ) in human keratinocytes . Negative_regulation PAF1 ARSA 6711391 37375 These studies suggest that regulates PAF availability unrelated to its effect on cyclooxygenase and that MC membrane products directly *inhibit* [PAF] activity from rat PLC . Negative_regulation PAF1 ARSA 8430224 212741 Since acetylsalicylic acid (ASA) is an accepted therapeutic alternative in these patients , we sought to determine if would *attenuate* endothelial cell [PAF] production resulting from ACA exposure . Negative_regulation PAF1 CD14 7541418 310477 The soluble form of ( sCD14 ) , when added to MO stimulated with LBP-LPS complexes , *inhibited* the synthesis of [PAF] possibly by competing with mCD14 . Negative_regulation PAF1 IL1B 1519663 196902 Stimulation of isolated mouse alveolar macrophages with recombinant murine or IL-1 alpha *resulted* in rapid , dose dependent , and cell concentration dependent increases in [PAF] secretion . Negative_regulation PAF1 TNF 9403541 469610 Furthermore , inhibiting [PAF] production with AACOCF3 , or manoalide , also *inhibited* LPS induced Mphi mRNA expression . Negative_regulation PAFAH1B1 TNF 22025632 2508089 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation PAK1 CCND1 15743831 1379111 Furthermore , PAK1 stimulated promoter activity was repressed by cotransfection of NF2 , and [PAK] activity was *inhibited* by expression of merlin . Negative_regulation PAK1 EPHB2 12546821 1051260 Overexpression of dominant negative receptor , catalytically inactive kalirin , or dominant negative Rac1 , or *inhibition* of [PAK] eliminates ephrin induced spine development . Negative_regulation PAK1 EPHB2 21209852 2359317 In addition , LPA *induced* [PAK1] activation while activation and cell migration were inhibited by ectopic expression of an inactive mutant form of PAK1 in MDA-MB-231 cells . Negative_regulation PAK2 CCND1 15743831 1379113 Furthermore , PAK1 stimulated promoter activity was repressed by cotransfection of NF2 , and [PAK] activity was *inhibited* by expression of merlin . Negative_regulation PAK2 EPHB2 12546821 1051265 Overexpression of dominant negative receptor , catalytically inactive kalirin , or dominant negative Rac1 , or *inhibition* of [PAK] eliminates ephrin induced spine development . Negative_regulation PAK3 CCND1 15743831 1379115 Furthermore , PAK1 stimulated promoter activity was repressed by cotransfection of NF2 , and [PAK] activity was *inhibited* by expression of merlin . Negative_regulation PAK3 EPHB2 12546821 1051270 Overexpression of dominant negative receptor , catalytically inactive kalirin , or dominant negative Rac1 , or *inhibition* of [PAK] eliminates ephrin induced spine development . Negative_regulation PAK4 CCND1 15743831 1379107 Furthermore , PAK1 stimulated promoter activity was repressed by cotransfection of NF2 , and [PAK] activity was *inhibited* by expression of merlin . Negative_regulation PAK4 EPHB2 12546821 1051250 Overexpression of dominant negative receptor , catalytically inactive kalirin , or dominant negative Rac1 , or *inhibition* of [PAK] eliminates ephrin induced spine development . Negative_regulation PAK6 CCND1 15743831 1379109 Furthermore , PAK1 stimulated promoter activity was repressed by cotransfection of NF2 , and [PAK] activity was *inhibited* by expression of merlin . Negative_regulation PAK6 EPHB2 12546821 1051255 Overexpression of dominant negative receptor , catalytically inactive kalirin , or dominant negative Rac1 , or *inhibition* of [PAK] eliminates ephrin induced spine development . Negative_regulation PAK7 CCND1 15743831 1379105 Furthermore , PAK1 stimulated promoter activity was repressed by cotransfection of NF2 , and [PAK] activity was *inhibited* by expression of merlin . Negative_regulation PAK7 EPHB2 12546821 1051245 Overexpression of dominant negative receptor , catalytically inactive kalirin , or dominant negative Rac1 , or *inhibition* of [PAK] eliminates ephrin induced spine development . Negative_regulation PAQR3 EPHB2 17724343 1789882 [RKTG] expression *inhibits* EGF stimulated and RSK phosphorylation , blocks NGF mediated PC12 cell differentiation , and antagonizes Ras- and Raf-1 stimulated Elk-1 transactivation . Negative_regulation PARD6A EFNB1 19276658 2106020 Finally , phosphorylation of on specific tyrosine residues can *block* the interaction between ephrinB1 and [Par-6] at tight junctions , and restore tight junction formation . Negative_regulation PARN TNF 2226778 144485 Stability studies of IL-6 transcripts in fibroblasts showed that *delayed* IL-6 [mRNA decay] but not LT . Negative_regulation PARP1 DGKI 15894621 1411625 regulates Ras guanyl releasing protein 3 and *inhibits* [Rap1] signaling . Negative_regulation PARP1 DGKI 15894621 1411653 We demonstrate that bound to RasGRP3 and *inhibited* its activation of [Rap1] by metabolizing DAG . Negative_regulation PARP1 EPHB2 19849845 2160409 In addition , we determined that in the estrogen treated rats there was an increase in the levels of ( p < 0.01 ) and Akt ( p < 0.05 ) at the 24 hour time-point , and that 17 beta-estradiol *blocked* the activation of caspase-3 ( p < 0.01 ) and subsequent cleavage of [PARP] ( p < 0.05 ) . Negative_regulation PARP1 EPHB2 20347949 2281893 In addition , MWG extract attenuated activation of caspase-3 and [poly ADP-ribose polymerase (PARP)] and *inhibited* the phosphorylation of , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation PARP1 IL1B 19765544 2147394 Minocycline repressed the expression of TNF-alpha , , and iNOS , decreased the apoptotic index , and *inhibited* [poly(ADP-ribose) polymerase-1] ( PARP-1 ) activity in the mouse small intestine . Negative_regulation PARP1 MAP2K6 17646383 1793333 The downregulation of [Rap1GAP] by Ras *required* the activation of the signal regulated kinase cascade and was correlated with the induction of mesenchymal morphology and migratory behavior . Negative_regulation PARP1 NMNAT2 11248244 793513 strongly *inhibited* recombinant human [poly(ADP-ribose) polymerase 1] , however , NMNAT was not modified by poly ( ADP-ribose ) . Negative_regulation PARP1 TNF 19765544 2147393 Minocycline repressed the expression of , IL-1beta , and iNOS , decreased the apoptotic index , and *inhibited* [poly(ADP-ribose) polymerase-1] ( PARP-1 ) activity in the mouse small intestine . Negative_regulation PARP1 TNFSF10 21687939 2460366 We studied the effects of [PARP] *inhibitors* ( AZD2281 and BSI-201 ) , paclitaxel , docetaxel , cisplatin and cisplatin plus on CSCs derived from CRL-2335 and MDA-MB-468 TNBC cells in vitro . Negative_regulation PARP10 EPHB2 19849845 2160389 In addition , we determined that in the estrogen treated rats there was an increase in the levels of ( p < 0.01 ) and Akt ( p < 0.05 ) at the 24 hour time-point , and that 17 beta-estradiol *blocked* the activation of caspase-3 ( p < 0.01 ) and subsequent cleavage of [PARP] ( p < 0.05 ) . Negative_regulation PARP10 EPHB2 20347949 2281888 In addition , MWG extract attenuated activation of caspase-3 and [poly ADP-ribose polymerase (PARP)] and *inhibited* the phosphorylation of , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation PARP10 TNFSF10 21687939 2460361 We studied the effects of [PARP] *inhibitors* ( AZD2281 and BSI-201 ) , paclitaxel , docetaxel , cisplatin and cisplatin plus on CSCs derived from CRL-2335 and MDA-MB-468 TNBC cells in vitro . Negative_regulation PARP11 EPHB2 19849845 2160373 In addition , we determined that in the estrogen treated rats there was an increase in the levels of ( p < 0.01 ) and Akt ( p < 0.05 ) at the 24 hour time-point , and that 17 beta-estradiol *blocked* the activation of caspase-3 ( p < 0.01 ) and subsequent cleavage of [PARP] ( p < 0.05 ) . Negative_regulation PARP11 EPHB2 20347949 2281884 In addition , MWG extract attenuated activation of caspase-3 and [poly ADP-ribose polymerase (PARP)] and *inhibited* the phosphorylation of , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation PARP11 TNFSF10 21687939 2460358 We studied the effects of [PARP] *inhibitors* ( AZD2281 and BSI-201 ) , paclitaxel , docetaxel , cisplatin and cisplatin plus on CSCs derived from CRL-2335 and MDA-MB-468 TNBC cells in vitro . Negative_regulation PARP12 EPHB2 19849845 2160381 In addition , we determined that in the estrogen treated rats there was an increase in the levels of ( p < 0.01 ) and Akt ( p < 0.05 ) at the 24 hour time-point , and that 17 beta-estradiol *blocked* the activation of caspase-3 ( p < 0.01 ) and subsequent cleavage of [PARP] ( p < 0.05 ) . Negative_regulation PARP12 EPHB2 20347949 2281886 In addition , MWG extract attenuated activation of caspase-3 and [poly ADP-ribose polymerase (PARP)] and *inhibited* the phosphorylation of , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation PARP12 TNFSF10 21687939 2460359 We studied the effects of [PARP] *inhibitors* ( AZD2281 and BSI-201 ) , paclitaxel , docetaxel , cisplatin and cisplatin plus on CSCs derived from CRL-2335 and MDA-MB-468 TNBC cells in vitro . Negative_regulation PARP14 EPHB2 19849845 2160425 In addition , we determined that in the estrogen treated rats there was an increase in the levels of ( p < 0.01 ) and Akt ( p < 0.05 ) at the 24 hour time-point , and that 17 beta-estradiol *blocked* the activation of caspase-3 ( p < 0.01 ) and subsequent cleavage of [PARP] ( p < 0.05 ) . Negative_regulation PARP14 EPHB2 20347949 2281897 In addition , MWG extract attenuated activation of caspase-3 and [poly ADP-ribose polymerase (PARP)] and *inhibited* the phosphorylation of , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation PARP14 TNFSF10 21687939 2460370 We studied the effects of [PARP] *inhibitors* ( AZD2281 and BSI-201 ) , paclitaxel , docetaxel , cisplatin and cisplatin plus on CSCs derived from CRL-2335 and MDA-MB-468 TNBC cells in vitro . Negative_regulation PARP15 EPHB2 19849845 2160401 In addition , we determined that in the estrogen treated rats there was an increase in the levels of ( p < 0.01 ) and Akt ( p < 0.05 ) at the 24 hour time-point , and that 17 beta-estradiol *blocked* the activation of caspase-3 ( p < 0.01 ) and subsequent cleavage of [PARP] ( p < 0.05 ) . Negative_regulation PARP15 EPHB2 20347949 2281891 In addition , MWG extract attenuated activation of caspase-3 and [poly ADP-ribose polymerase (PARP)] and *inhibited* the phosphorylation of , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation PARP15 TNFSF10 21687939 2460364 We studied the effects of [PARP] *inhibitors* ( AZD2281 and BSI-201 ) , paclitaxel , docetaxel , cisplatin and cisplatin plus on CSCs derived from CRL-2335 and MDA-MB-468 TNBC cells in vitro . Negative_regulation PARP16 EPHB2 19849845 2160393 In addition , we determined that in the estrogen treated rats there was an increase in the levels of ( p < 0.01 ) and Akt ( p < 0.05 ) at the 24 hour time-point , and that 17 beta-estradiol *blocked* the activation of caspase-3 ( p < 0.01 ) and subsequent cleavage of [PARP] ( p < 0.05 ) . Negative_regulation PARP16 EPHB2 20347949 2281889 In addition , MWG extract attenuated activation of caspase-3 and [poly ADP-ribose polymerase (PARP)] and *inhibited* the phosphorylation of , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation PARP16 TNFSF10 21687939 2460362 We studied the effects of [PARP] *inhibitors* ( AZD2281 and BSI-201 ) , paclitaxel , docetaxel , cisplatin and cisplatin plus on CSCs derived from CRL-2335 and MDA-MB-468 TNBC cells in vitro . Negative_regulation PARP2 EPHB2 19849845 2160417 In addition , we determined that in the estrogen treated rats there was an increase in the levels of ( p < 0.01 ) and Akt ( p < 0.05 ) at the 24 hour time-point , and that 17 beta-estradiol *blocked* the activation of caspase-3 ( p < 0.01 ) and subsequent cleavage of [PARP] ( p < 0.05 ) . Negative_regulation PARP2 EPHB2 20347949 2281895 In addition , MWG extract attenuated activation of caspase-3 and [poly ADP-ribose polymerase (PARP)] and *inhibited* the phosphorylation of , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation PARP2 TNFSF10 21687939 2460368 We studied the effects of [PARP] *inhibitors* ( AZD2281 and BSI-201 ) , paclitaxel , docetaxel , cisplatin and cisplatin plus on CSCs derived from CRL-2335 and MDA-MB-468 TNBC cells in vitro . Negative_regulation PARP3 EPHB2 19849845 2160421 In addition , we determined that in the estrogen treated rats there was an increase in the levels of ( p < 0.01 ) and Akt ( p < 0.05 ) at the 24 hour time-point , and that 17 beta-estradiol *blocked* the activation of caspase-3 ( p < 0.01 ) and subsequent cleavage of [PARP] ( p < 0.05 ) . Negative_regulation PARP3 EPHB2 20347949 2281896 In addition , MWG extract attenuated activation of caspase-3 and [poly ADP-ribose polymerase (PARP)] and *inhibited* the phosphorylation of , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation PARP3 TNFSF10 21687939 2460369 We studied the effects of [PARP] *inhibitors* ( AZD2281 and BSI-201 ) , paclitaxel , docetaxel , cisplatin and cisplatin plus on CSCs derived from CRL-2335 and MDA-MB-468 TNBC cells in vitro . Negative_regulation PARP4 EPHB2 19849845 2160413 In addition , we determined that in the estrogen treated rats there was an increase in the levels of ( p < 0.01 ) and Akt ( p < 0.05 ) at the 24 hour time-point , and that 17 beta-estradiol *blocked* the activation of caspase-3 ( p < 0.01 ) and subsequent cleavage of [PARP] ( p < 0.05 ) . Negative_regulation PARP4 EPHB2 20347949 2281894 In addition , MWG extract attenuated activation of caspase-3 and [poly ADP-ribose polymerase (PARP)] and *inhibited* the phosphorylation of , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation PARP4 TNFSF10 21687939 2460367 We studied the effects of [PARP] *inhibitors* ( AZD2281 and BSI-201 ) , paclitaxel , docetaxel , cisplatin and cisplatin plus on CSCs derived from CRL-2335 and MDA-MB-468 TNBC cells in vitro . Negative_regulation PARP6 EPHB2 19849845 2160405 In addition , we determined that in the estrogen treated rats there was an increase in the levels of ( p < 0.01 ) and Akt ( p < 0.05 ) at the 24 hour time-point , and that 17 beta-estradiol *blocked* the activation of caspase-3 ( p < 0.01 ) and subsequent cleavage of [PARP] ( p < 0.05 ) . Negative_regulation PARP6 EPHB2 20347949 2281892 In addition , MWG extract attenuated activation of caspase-3 and [poly ADP-ribose polymerase (PARP)] and *inhibited* the phosphorylation of , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation PARP6 TNFSF10 21687939 2460365 We studied the effects of [PARP] *inhibitors* ( AZD2281 and BSI-201 ) , paclitaxel , docetaxel , cisplatin and cisplatin plus on CSCs derived from CRL-2335 and MDA-MB-468 TNBC cells in vitro . Negative_regulation PARP8 EPHB2 19849845 2160397 In addition , we determined that in the estrogen treated rats there was an increase in the levels of ( p < 0.01 ) and Akt ( p < 0.05 ) at the 24 hour time-point , and that 17 beta-estradiol *blocked* the activation of caspase-3 ( p < 0.01 ) and subsequent cleavage of [PARP] ( p < 0.05 ) . Negative_regulation PARP8 EPHB2 20347949 2281890 In addition , MWG extract attenuated activation of caspase-3 and [poly ADP-ribose polymerase (PARP)] and *inhibited* the phosphorylation of , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation PARP8 TNFSF10 21687939 2460363 We studied the effects of [PARP] *inhibitors* ( AZD2281 and BSI-201 ) , paclitaxel , docetaxel , cisplatin and cisplatin plus on CSCs derived from CRL-2335 and MDA-MB-468 TNBC cells in vitro . Negative_regulation PARP9 EPHB2 19849845 2160385 In addition , we determined that in the estrogen treated rats there was an increase in the levels of ( p < 0.01 ) and Akt ( p < 0.05 ) at the 24 hour time-point , and that 17 beta-estradiol *blocked* the activation of caspase-3 ( p < 0.01 ) and subsequent cleavage of [PARP] ( p < 0.05 ) . Negative_regulation PARP9 EPHB2 20347949 2281887 In addition , MWG extract attenuated activation of caspase-3 and [poly ADP-ribose polymerase (PARP)] and *inhibited* the phosphorylation of , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs . Negative_regulation PARP9 TNFSF10 21687939 2460360 We studied the effects of [PARP] *inhibitors* ( AZD2281 and BSI-201 ) , paclitaxel , docetaxel , cisplatin and cisplatin plus on CSCs derived from CRL-2335 and MDA-MB-468 TNBC cells in vitro . Negative_regulation PAX7 FOXO1 21321994 2410775 Here we show that while inhibits MyoD dependent transcription , MyoD *enhances* [Pax7-FKHR] activity in myogenic cell cultures . Negative_regulation PAX8 TNF 10499522 647815 In the present study , we show that *suppresses* DNA binding activity of thyroid transcription factors , [Pax-8] and thyroid transcription factor-1 ( TTF-1 ) , which is , in part , involved in TNF-alpha induced decrease in TG gene expression . Negative_regulation PBX2 SLC38A3 6095679 43020 Proglumide , known to inhibit cholecystokinin binding to pancreatic acinar cell receptors , also inhibited 125I- [ Leu15 ] binding to the SCEF and *inhibited* [G-17] stimulated SLI release . Negative_regulation PCBD1 ALOX5 9615721 509554 This is in marked contrast to the extensive type 1 [PCD] *induced* by <5-lipoxygenase> inhibitors cultured with human U937 monoblastoid cells . Negative_regulation PCBD1 FOXA1 12351175 992891 Antisense inhibition experiments show that zygotic expression of the and Manx genes is *required* to prevent notochord [PCD] in urodele species and hybrids with restored tails . Negative_regulation PCBD1 IL1B 1940344 170590 and TNF-alpha *prevent* monocyte [PCD] , which suggests that viability may be regulated by biologically active peptides released during inflammation . Negative_regulation PCBD1 IL1B 1993844 154229 Moreover , exogenous human rTNF-alpha or also *prevented* [PCD] , suggesting that PCD is regulated by certain cytokines released from LPS stimulated monocytes . Negative_regulation PCBD1 TNF 1940344 170589 IL-1 beta and *prevent* monocyte [PCD] , which suggests that viability may be regulated by biologically active peptides released during inflammation . Negative_regulation PCBP1 IL1B 15967798 1446109 Iron influx increased the association of alphaCP1 with ferritin mRNA and decreased the alphaCP2-ferritin mRNA interaction , whereas *reduced* the association of [alphaCP1] and alphaCP2 with H-ferritin mRNA . Negative_regulation PCBP2 IL1B 15967798 1446110 Iron influx increased the association of alphaCP1 with ferritin mRNA and decreased the alphaCP2-ferritin mRNA interaction , whereas *reduced* the association of alphaCP1 and [alphaCP2] with H-ferritin mRNA . Negative_regulation PCK1 FOXO1 11467835 840751 The insulin responsive H4IIEC3 rat hepatoma cell line ( H4 cells ) was used in order to determine the *role* of the transcription factor in the regulation of [phosphoenolpyruvate carboxykinase] ( PEPCK ) and glucose-6-phosphatase (G6Pase) . Negative_regulation PCK1 FOXO1 21655268 2442305 Moreover , we found that exendin-4 treatment increased hepatic AKT and phosphorylation and *inhibited* glucose-6-phosphotase ( G6P ) and [Phosphoenolpyruvate carboxykinase] ( PEPCK ) expression in young mice , but this effect was attenuated in aging mice while the insulin sensitivity showed no change in the young group but significantly improved in aging mice . Negative_regulation PCK1 FOXO1 23995837 2856087 siRNA knockdown of FoxO1 decreased , whereas overexpression of *increased* , TH-dependent transcriptional activation of [PCK1] and G6PC in cultured hepatic cells . Negative_regulation PCK1 IL1B 8947481 400518 In the *presence* of recombinant human ( rh ) or rhTNF alpha the increase in [PCK] mRNA levels was totally inhibited at 0.1 nM glucagon , whereas at 1 nM glucagon the maximal increase was inhibited by only 25 % . Negative_regulation PCK2 FOXO1 11467835 840752 The insulin responsive H4IIEC3 rat hepatoma cell line ( H4 cells ) was used in order to determine the *role* of the transcription factor in the regulation of [phosphoenolpyruvate carboxykinase] ( PEPCK ) and glucose-6-phosphatase (G6Pase) . Negative_regulation PCK2 FOXO1 21655268 2442309 Moreover , we found that exendin-4 treatment increased hepatic AKT and phosphorylation and *inhibited* glucose-6-phosphotase ( G6P ) and [Phosphoenolpyruvate carboxykinase] ( PEPCK ) expression in young mice , but this effect was attenuated in aging mice while the insulin sensitivity showed no change in the young group but significantly improved in aging mice . Negative_regulation PCK2 IL1B 8947481 400519 In the *presence* of recombinant human ( rh ) or rhTNF alpha the increase in [PCK] mRNA levels was totally inhibited at 0.1 nM glucagon , whereas at 1 nM glucagon the maximal increase was inhibited by only 25 % . Negative_regulation PCNA CCND1 11114718 759174 The kinase activities of cyclin D/CDK4 , 6 and cyclin E/CDK2 complexes were only slightly elevated , consistent with the findings that coordinate increases in p21 , and cyclin E *resulted* in an increase in [cyclin/CDK/p21] complexes . Negative_regulation PCNA CCND1 15378598 1298139 In analyses of key cell-cycle regulating proteins , we observed that GFP-ER expression had no affect on the protein levels of , cyclin E , or p27 , a [cyclin dependent kinase (Cdk)] *inhibitor* . Negative_regulation PCNA CCND1 18301453 1671234 We investigated 110 subjects ( 43 invasive squamous cell carcinoma ( ISCC ) , 38 CIN III , 11 CIN II , 18 CIN I ) confirmed to be positive for HPV16 and/or 18 as well as 20 normal cervical tissue ( NCT ) samples for abnormal expression of , cyclin E , CDK4 , [cyclin] *inhibitors* ( p21 ( waf ) , p27 , p16 (INK4A) ) and Ki-67 using immunohistochemistry and differential PCR techniques . Negative_regulation PCNA CCND1 23079655 2690370 Ubiquitous shutdown of or *inhibition* of [cyclin] D-associated kinase activity in mice bearing ErbB2-driven mammary carcinomas triggered tumor cell senescence , without compromising the animals ' health . Negative_regulation PCNA CCND1 7958844 278220 Altogether , these results indicate that down-regulation of is *necessary* for [PCNA] relocation and repair DNA synthesis as well as for the start of DNA replication . Negative_regulation PCNA CCND1 8756619 377567 Overexpression of *restores* [cyclin] A transcription in suspended cells and rescues them from cell cycle arrest . Negative_regulation PCNA CCND1 9169494 432867 overexpression *resulted* in a concomitant increase in CDK4 levels in the adult myocardium , as well as modest increases in [proliferating cell nuclear antigen] and CDK2 levels . Negative_regulation PCNA CDKN1C 10523650 653536 We show that expression of , a potent tight binding *inhibitor* of several G ( 1 ) [cyclin-cyclin dependent kinase (Cdk)] complexes , increases markedly during C2C12 myoblast differentiation . Negative_regulation PCNA CDKN1C 10523650 653538 Taken together , our data suggest that *repression* of [cyclin] E-Cdk2 mediated phosphorylation of MyoD by could play an important role in the accumulation of MyoD at the onset of myoblast differentiation . Negative_regulation PCNA CDKN1C 11135238 769702 We have found that a [cyclin] kinase *inhibitor* , , is expressed in a restricted group of amacrine cells in the inner nuclear layer ( INL ) and ganglion cell layer ( GCL ) of the rodent retina . Negative_regulation PCNA CDKN1C 15294951 1279031 Most notably , increased levels *resulted* in marked inhibition of both cyclin E- and [cyclin] A-associated cdk2 kinase activities and a decrease in cyclin A amounts . Negative_regulation PCNA CDKN1C 17050328 1636110 , a KIP family [cyclin dependent kinase (Cdk)] *inhibitor* , blocks the cell cycle by acting on multiple cyclin-Cdk complexes . Negative_regulation PCNA CDKN1C 18986530 2001358 ( [cyclin] kinase *inhibitor* 1 ) was induced early but repressed at later times . Negative_regulation PCNA CDKN1C 20503313 2263861 A small number of individuals with BWS ( 5-10 % ) have mutations in , a cyclin dependent kinase *inhibitor* of G1 [cyclin] complexes that functions as a negative regulator of cellular growth and proliferation . Negative_regulation PCNA EDN2 18973526 2086080 The *roles* of the receptors A and B ( ET ( A ) and ET ( B ) ) in CsA enhanced expression of [PCNA] and iNOS were examined in cultured human gingival fibroblasts pretreated with receptor antagonists , by immunocytochemistry and RT-PCR , respectively . Negative_regulation PCNA EPHB2 14580716 1156992 We further show that normal rhesus OSE cells do not activate ERK or Akt in response to estradiol , nor does estradiol block the ability of serum to stimulate or *induce* [cyclin] D expression . Negative_regulation PCNA EPHB2 18404517 1497304 Because FGF2 and P2 purinergic receptors are coupled to extracellular signal regulated protein kinase ( ERK ) , a key member of a signaling cascade that regulates proliferation , we also investigated the *role* of in regulating [cyclin] expression induced by FGF2 and ATP . Negative_regulation PCNA FAS 15052671 1229818 VES inhibited the growth of gastric cancer cells by inducing expression and *inhibiting* [PCNA] expression . Negative_regulation PCNA FAS 18483205 1939089 Our data indicate that in human CD8+ T-cell blasts , ligation , and especially Apo2L/TRAIL *induce* the p53 dependent decrease in [cyclin-B1] levels . Negative_regulation PCNA FAS 23671449 2785114 Meanwhile , EsA reduced the serum IL-6 and TNF-a levels ( p < 0.05 ) , *inhibited* the expression of [PCNA] and promoted the expression of caspase-3 , and FasL in animals of the treated group ( p < 0.05 ) . Negative_regulation PCNA ID1 12949053 1158038 In the PLC/PRF/5 HCC cell line study , ectopic expression *resulted* in proliferation of HCC cells and an increased percentage of S phase cells and [PCNA] expression . Negative_regulation PCNA IFI27 10510327 651075 The majority of thyroid carcinomas maintain the expression of the cell growth suppressor , an *inhibitor* of [cyclin dependent kinase-2 (Cdk2)] . Negative_regulation PCNA IFI27 10683182 669556 We show that the effect on cell proliferation is likely to be mediated by ( XIC1 ) , a [cyclin dependent kinase (cdk)] *inhibitor* . Negative_regulation PCNA IFI27 10972198 728966 Taken our results together , we suggested that ginsenoside Rg3 activated the expression of [cyclin-kinase] *inhibitors* , p21 and , arrested LNCaP cells at G1 phase , and subsequently inhibited cell growth through a caspase3 mediated apoptosis mechanism . Negative_regulation PCNA IFI27 11205265 763518 The cycle regulatory protein , an *inhibitor* of [cyclin dependent kinase (CDK)] , has been attributed a role in resistance to cancer chemotherapy . Negative_regulation PCNA IFI27 11237531 790115 A major function of , also known as Kip1 , is to bind and *inhibit* [cyclin/cyclin] dependent kinase complexes , thereby blocking cell cycle progression . Negative_regulation PCNA IFI27 11585732 866248 Reduced expression of ( Kip1 ) , a [cyclin dependent kinase (Cdk)] *inhibitor* , is frequently found in various cancers , including oral squamous cell carcinoma ( OSCC ) , and is attributable to an enhancement of its degradation . Negative_regulation PCNA IFI27 11756218 899071 Neither p21 nor , two [cyclin] kinase *inhibitors* , were significantly modified by carotenoid treatment . Negative_regulation PCNA IFI27 11846217 893267 The mechanism toward survival requires the blocking of proliferation at the G1/S boundary of the cell cycle that is mediated by the [cyclin dependent kinase (cdk)] *inhibitor* , and the induction of a cdk inhibitor , p21waf1 . Negative_regulation PCNA IFI27 12631353 1067738 We investigated for alterations in the expression of [cyclin] kinase *inhibitors* , , p57 , p21 , and cyclins D and A in the podocyte cell of children with INS . Negative_regulation PCNA IFI27 12856162 1173947 The overexpression of , a [cyclin dependent kinase (CDK)] *inhibitor* , has been shown to effectively inhibit cell growth at the G1-phase of different cell lines , potentiating a valid genetic strategy for cell proliferation control . Negative_regulation PCNA IFI27 14707456 1181040 Previous studies have shown that low levels of ( KIP1 ) , an *inhibitor* of G1 [cyclin dependent kinases (CDK)] , are associated with high aggressiveness and poor prognosis in a variety of cancers . Negative_regulation PCNA IFI27 15351092 1292534 Whereas E2 increases the level of the various cyclins involved in the cell cycle progression and decreases the [cyclin] kinase *inhibitors* , p21 and , progestins act in an opposite manner . Negative_regulation PCNA IFI27 15542638 1337426 Interestingly , EBNA3C also bound human cyclins D1 and E in vitro , although the affinity was approximately 30 % of that seen for cyclin A. Previously it was demonstrated that full-length EBNA3C rescues *mediated* suppression of [cyclin] A-dependent kinase activity ( J. S. Knight and E. S. Robertson , J. Virol. 78 : 1981-1991 , 2004 ) . Negative_regulation PCNA IFI27 15557280 1367896 We found that overexpression of wild-type FAK promoted exit from G ( 1 ) in monolayer cultures of glioblastoma cells , enhanced the expression of cyclins D1 and E while reducing the expression of ( Kip1 ) and p21 ( Waf1 ) , and *enhanced* the kinase activity of the cyclin [D1-cyclin dependent kinase-4 (cdk4)] complex . Negative_regulation PCNA IFI27 16730872 1576258 Further investigation into the mechanism revealed that Cd treatment led to down-modulation of cyclin dependent kinases , Cdk1 and Cdk2 , apparently by elevating the expression of [cyclin] kinase *inhibitors* , and WAF1/p21 . Negative_regulation PCNA IFI27 19724954 2271929 [Cyclin-dependent-kinase (cdk)] *inhibitor* , ( Kip1 ) ( p27 ) , has been shown to participate in progestin induced growth suppression of normal endometrial glands . Negative_regulation PCNA IFI27 21203424 2359096 Furthermore , upregulation of miR-96 in breast cancer cells resulted in modulation of their entry into the G1/S transitional phase , which was caused by downregulation of [cyclin dependent kinase (CDK)] *inhibitors* , ( Kip1 ) and p21 ( Cip1 ) , and upregulation of the cell-cycle regulator cyclin D1 . Negative_regulation PCNA IFI27 21393425 2426774 Immunoblot analyses reveal enhanced phosphorylation of Akt , extracellular signal regulated kinase ( ERK ) , BAD , increased expression of cyclins ( A1/D1 ) , and decreased expression of [cyclin] *inhibitor* ( ) on PP2A downregulation . Negative_regulation PCNA IFI27 22917534 2683134 We have discovered that ERK5 suppressed the expression of the [cyclin dependent protein kinase (CDKs)] *inhibitors* , p21 and , by decreasing mRNA and protein stability , respectively . Negative_regulation PCNA IFI27 23219869 2763755 N-POMC1-28 increases [cyclin] D expression and *inhibits* ( kip1 ) in the adrenal cortex . Negative_regulation PCNA IFI27 8033213 264081 , a novel *inhibitor* of G1 [cyclin-Cdk] protein kinase activity , is related to p21 . Negative_regulation PCNA IFI27 9042862 416136 Upon being induced by TGF-beta or with a conditional expression system in lung epithelial cells , p15(Ink4b) binds to and inhibits the cyclin D-dependent kinases , prevents p27 binding to these cdk complexes , and promotes binding and *inhibition* of [cyclin-cdk2] . Negative_regulation PCNA PECAM1 16317135 1487602 The GTPs+UVB group also had reduced expressions of and vascular endothelial growth factor , which are essential for angiogenesis , and *inhibited* expression of [proliferating cell nuclear antigen] in the tumors compared with the UVB group . Negative_regulation PCNA SYNM 22113341 2658125 also *resulted* in a repression of [cyclin] or cyclin-like transcripts . Negative_regulation PCNA TNF 10347813 616848 We examined the effects of ( 1-100 ng/ml ) and butyrolactone I ( 100 microM ) , a specific *inhibitor* of [cyclin dependent kinases (CDK)] with high selectivity for CDK-1 and CDK-2 , on three different cancer cell lines : WEHI , L929 and HeLa S3 . Negative_regulation PCNA TNF 12193463 981271 inhibited de novo cyclin A mRNA synthesis and *suppressed* [cyclin] A promoter activity . Negative_regulation PCNA TNF 15976518 1424460 Inhibition of JNK by over-expression of dominant negative JNK1 substantially reversed *mediated* inhibition of [cyclin] A expression and EC proliferation , suggesting modulation of JNK1 signaling as the mechanism for ethanol/TNF induced EC dysfunctions . Negative_regulation PCNA TNF 16387162 1494293 Compared to CsA therapy , increased TRL concentrations did not further inhibit [PCNA] expression , inhibited CD25 expression less on days 1 and 2 and equally high on day 3 , but *inhibited* expression of IL-2 and significantly higher on days 2 and 3 ( P < .05 ) . Negative_regulation PCNA TNF 23671449 2785113 Meanwhile , EsA reduced the serum IL-6 and levels ( p < 0.05 ) , *inhibited* the expression of [PCNA] and promoted the expression of caspase-3 , Fas and FasL in animals of the treated group ( p < 0.05 ) . Negative_regulation PCNA TNF 8670156 369617 also *suppressed* expression of [proliferating cell nuclear antigen] , indicating that it had an anti-proliferative activity on OST cells . Negative_regulation PCNA TNFSF10 18483205 1939090 Our data indicate that in human CD8+ T-cell blasts , Fas ligation , and especially *induce* the p53 dependent decrease in [cyclin-B1] levels . Negative_regulation PCSK9 ANXA2 24808179 2950607 *reduces* [PCSK9] protein levels via a translational mechanism and interacts with the M1 and M2 domains of PCSK9 . Negative_regulation PCSK9 ANXA2 24808179 2950608 In this study , we investigated the effect of silencing the expression of AnxA2 and PCSK9 in HepG2 and Huh7 cells to better define the *role* of in [PCSK9] regulation . Negative_regulation PCSK9 ANXA2 24808179 2950611 Overall , our data revealed a plausible new *role* of in the reduction of [PCSK9] protein levels via a translational mechanism . Negative_regulation PCSK9 APOB 17493938 1766640 Finally , we show that *diminishes* [PCSK9] binding to LDLR in vitro and partially inhibits the effects of secreted PCSK9 on LDLR degradation in cell culture . Negative_regulation PCSK9 APOB 23400816 2759542 also *inhibited* [PCSK9] binding to mutant LDLRs defective at binding LDL . Negative_regulation PCSK9 COG2 23317404 2769563 Very recent data revealed that absence of [PCSK9] can be protective against melanoma invasion in mouse liver , and that this is *due* to lower circulating . Negative_regulation PCSK9 EGF 18675252 1955165 Importantly , binding of [PCSK9] to either LDLR or mouse VLDLR was effectively *inhibited* by while binding to ApoER2 was less affected . Negative_regulation PCSK9 EGF 24103783 2863564 Characterization of the *role* of of low density lipoprotein receptor in [PCSK9] binding . Negative_regulation PCSK9 EGF 24103783 2863570 Here , we further characterized the *role* of in binding of [PCSK9] to the LDLR . Negative_regulation PCSK9 FDFT1 18054775 1861153 Inhibition of *upregulates* [PCSK9] expression in rat liver . Negative_regulation PCSK9 GH1 20884874 2347335 , known to be increased during fasting in humans , *reduced* circulating [PCSK9] in parallel to LDL cholesterol levels . Negative_regulation PCSK9 LDLR 23690465 2801368 Conversely , acute expression of human in transgenic mice *caused* a 70 % decrease in serum murine [PCSK9] levels . Negative_regulation PCSK9 LDLR 24103783 2863565 Characterization of the *role* of EGF-A of in [PCSK9] binding . Negative_regulation PCSK9 MAPK3 22593575 2619797 [PCSK9] expression was *induced* by inhibition of activity but inhibited by ERK1/2 activation . Negative_regulation PCSK9 MAPK3 22593575 2619799 The mutagenic study and promoter activity assay suggested that the *induction* of [PCSK9] expression by inhibitors was tightly linked to PPAR? dephosphorylation . Negative_regulation PCSK9 SIRT6 23974119 2850532 Hepatic deficiency *leads* to elevated [Pcsk9] gene expression and LDL-cholesterol as well . Negative_regulation PDC FOXO1 22315317 2580510 The *role* of and PPAR transcription factors in diet mediated inhibition of [PDC] activation and carbohydrate oxidation during exercise in humans and the role of pharmacological activation of PDC in overriding these changes . Negative_regulation PDC OSR1 21209911 2359423 This downregulatory effect was abolished when the of HIF-1a ( HIF-1a-?ODD , the domain responsible for HIF-1a degradation ) was experimentally deleted or when the activity of HIF-1a [prolyl hydroxylase (PHD)] or the 26S proteasomal complex was *inhibited* , indicating that the 1 , 9 PA downregulates HIF-1a by promoting PHD dependent HIF-1a degradation . Negative_regulation PDC TNF 17082589 1643213 We identified CD14+ monocytes as the source of and IL-10 in the HCV core *induced* inhibition of [PDC] IFN-alpha production . Negative_regulation PDCD1 CAPN8 10825507 696516 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Negative_regulation PDCD1 CCND1 17525529 1751388 Here , we discuss the molecular mechanisms that regulate [programmed cell death] *induced* by disruption of the complex and consider the wider implications these findings have for the future development of novel chemotherapeutic agents . Negative_regulation PDCD1 CLU 10854058 704196 These findings indicate that depletion of can *lead* to the [programmed cell death] in ovary , suggesting a functional role for this protein in follicular atresia . Negative_regulation PDCD1 CLU 22358960 178183 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Negative_regulation PDCD1 FAS 1689786 128386 Binding of to cells expressing APO-1 *results* in [programmed cell death] , apoptosis , the most common form of death in eukaryotic cells . Negative_regulation PDCD1 FAS 8758891 377803 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Negative_regulation PDCD1 FAS 9177220 434086 In addition to providing costimulatory signals for cell proliferation , ligation of both TNFR1 and can *result* in [programmed cell death] or apoptosis . Negative_regulation PDCD1 FAS 9188860 437475 Regulation of dependent activation induced T cell apoptosis by cAMP signaling : a potential role for transcription factor NF-kappa B . TCR mediated activation of T cell hybridomas *induces* [programmed cell death] by a Fas dependent pathway . Negative_regulation PDCD1 IL1B 1993844 154216 Lipopolysaccharide , tumor necrosis factor-alpha , and *prevent* [programmed cell death] ( apoptosis ) in human peripheral blood monocytes . Negative_regulation PDCD1 IL1B 9670975 519734 Since an antisense oligonucleotide for IL-1 beta , a blocking Ab to IL-1 beta , and preincubation with the IL-1R antagonist all prevent the delay in apoptosis , we conclude that acts in an autocrine manner to *inhibit* granulocyte [programmed cell death] . Negative_regulation PDCD1 TNF 1993844 154215 Lipopolysaccharide , , and IL-1 beta *prevent* [programmed cell death] ( apoptosis ) in human peripheral blood monocytes . Negative_regulation PDCD1 TNF 20832854 2325309 It is thus suggested that the co-immobilized TNF-a plus IFN-? promotes the activation of some unknown key markers in response to IFN-? , and the binding of the co-immobilized plus IFN-? with some other TNF-a receptors *results* in enhanced [programmed cell death] in HeLa cells . Negative_regulation PDCD1 TNF 8758891 377802 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Negative_regulation PDCD10 CAPN8 10825507 696530 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Negative_regulation PDCD10 CCND1 17525529 1751390 Here , we discuss the molecular mechanisms that regulate [programmed cell death] *induced* by disruption of the complex and consider the wider implications these findings have for the future development of novel chemotherapeutic agents . Negative_regulation PDCD10 CLU 10854058 704197 These findings indicate that depletion of can *lead* to the [programmed cell death] in ovary , suggesting a functional role for this protein in follicular atresia . Negative_regulation PDCD10 CLU 22358960 178184 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Negative_regulation PDCD10 FAS 1689786 128387 Binding of to cells expressing APO-1 *results* in [programmed cell death] , apoptosis , the most common form of death in eukaryotic cells . Negative_regulation PDCD10 FAS 8758891 377805 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Negative_regulation PDCD10 FAS 9177220 434088 In addition to providing costimulatory signals for cell proliferation , ligation of both TNFR1 and can *result* in [programmed cell death] or apoptosis . Negative_regulation PDCD10 FAS 9188860 437476 Regulation of dependent activation induced T cell apoptosis by cAMP signaling : a potential role for transcription factor NF-kappa B . TCR mediated activation of T cell hybridomas *induces* [programmed cell death] by a Fas dependent pathway . Negative_regulation PDCD10 IL1B 1993844 154218 Lipopolysaccharide , tumor necrosis factor-alpha , and *prevent* [programmed cell death] ( apoptosis ) in human peripheral blood monocytes . Negative_regulation PDCD10 IL1B 9670975 519735 Since an antisense oligonucleotide for IL-1 beta , a blocking Ab to IL-1 beta , and preincubation with the IL-1R antagonist all prevent the delay in apoptosis , we conclude that acts in an autocrine manner to *inhibit* granulocyte [programmed cell death] . Negative_regulation PDCD10 TNF 1993844 154217 Lipopolysaccharide , , and IL-1 beta *prevent* [programmed cell death] ( apoptosis ) in human peripheral blood monocytes . Negative_regulation PDCD10 TNF 20832854 2325310 It is thus suggested that the co-immobilized TNF-a plus IFN-? promotes the activation of some unknown key markers in response to IFN-? , and the binding of the co-immobilized plus IFN-? with some other TNF-a receptors *results* in enhanced [programmed cell death] in HeLa cells . Negative_regulation PDCD10 TNF 8758891 377804 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Negative_regulation PDCD11 CAPN8 10825507 696502 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Negative_regulation PDCD11 CCND1 17525529 1751386 Here , we discuss the molecular mechanisms that regulate [programmed cell death] *induced* by disruption of the complex and consider the wider implications these findings have for the future development of novel chemotherapeutic agents . Negative_regulation PDCD11 CLU 10854058 704195 These findings indicate that depletion of can *lead* to the [programmed cell death] in ovary , suggesting a functional role for this protein in follicular atresia . Negative_regulation PDCD11 CLU 22358960 178182 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Negative_regulation PDCD11 FAS 1689786 128385 Binding of to cells expressing APO-1 *results* in [programmed cell death] , apoptosis , the most common form of death in eukaryotic cells . Negative_regulation PDCD11 FAS 8758891 377801 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Negative_regulation PDCD11 FAS 9177220 434084 In addition to providing costimulatory signals for cell proliferation , ligation of both TNFR1 and can *result* in [programmed cell death] or apoptosis . Negative_regulation PDCD11 FAS 9188860 437474 Regulation of dependent activation induced T cell apoptosis by cAMP signaling : a potential role for transcription factor NF-kappa B . TCR mediated activation of T cell hybridomas *induces* [programmed cell death] by a Fas dependent pathway . Negative_regulation PDCD11 IL1B 1993844 154214 Lipopolysaccharide , tumor necrosis factor-alpha , and *prevent* [programmed cell death] ( apoptosis ) in human peripheral blood monocytes . Negative_regulation PDCD11 IL1B 9670975 519733 Since an antisense oligonucleotide for IL-1 beta , a blocking Ab to IL-1 beta , and preincubation with the IL-1R antagonist all prevent the delay in apoptosis , we conclude that acts in an autocrine manner to *inhibit* granulocyte [programmed cell death] . Negative_regulation PDCD11 TNF 1993844 154213 Lipopolysaccharide , , and IL-1 beta *prevent* [programmed cell death] ( apoptosis ) in human peripheral blood monocytes . Negative_regulation PDCD11 TNF 20832854 2325308 It is thus suggested that the co-immobilized TNF-a plus IFN-? promotes the activation of some unknown key markers in response to IFN-? , and the binding of the co-immobilized plus IFN-? with some other TNF-a receptors *results* in enhanced [programmed cell death] in HeLa cells . Negative_regulation PDCD11 TNF 8758891 377800 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Negative_regulation PDCD2 CAPN8 10825507 696544 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Negative_regulation PDCD2 CCND1 17525529 1751392 Here , we discuss the molecular mechanisms that regulate [programmed cell death] *induced* by disruption of the complex and consider the wider implications these findings have for the future development of novel chemotherapeutic agents . Negative_regulation PDCD2 CLU 10854058 704198 These findings indicate that depletion of can *lead* to the [programmed cell death] in ovary , suggesting a functional role for this protein in follicular atresia . Negative_regulation PDCD2 CLU 22358960 178185 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Negative_regulation PDCD2 FAS 1689786 128388 Binding of to cells expressing APO-1 *results* in [programmed cell death] , apoptosis , the most common form of death in eukaryotic cells . Negative_regulation PDCD2 FAS 8758891 377807 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Negative_regulation PDCD2 FAS 9177220 434090 In addition to providing costimulatory signals for cell proliferation , ligation of both TNFR1 and can *result* in [programmed cell death] or apoptosis . Negative_regulation PDCD2 FAS 9188860 437477 Regulation of dependent activation induced T cell apoptosis by cAMP signaling : a potential role for transcription factor NF-kappa B . TCR mediated activation of T cell hybridomas *induces* [programmed cell death] by a Fas dependent pathway . Negative_regulation PDCD2 IL1B 1993844 154220 Lipopolysaccharide , tumor necrosis factor-alpha , and *prevent* [programmed cell death] ( apoptosis ) in human peripheral blood monocytes . Negative_regulation PDCD2 IL1B 9670975 519736 Since an antisense oligonucleotide for IL-1 beta , a blocking Ab to IL-1 beta , and preincubation with the IL-1R antagonist all prevent the delay in apoptosis , we conclude that acts in an autocrine manner to *inhibit* granulocyte [programmed cell death] . Negative_regulation PDCD2 TNF 1993844 154219 Lipopolysaccharide , , and IL-1 beta *prevent* [programmed cell death] ( apoptosis ) in human peripheral blood monocytes . Negative_regulation PDCD2 TNF 20832854 2325311 It is thus suggested that the co-immobilized TNF-a plus IFN-? promotes the activation of some unknown key markers in response to IFN-? , and the binding of the co-immobilized plus IFN-? with some other TNF-a receptors *results* in enhanced [programmed cell death] in HeLa cells . Negative_regulation PDCD2 TNF 8758891 377806 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Negative_regulation PDCD4 CAPN8 10825507 696558 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Negative_regulation PDCD4 CCND1 17525529 1751394 Here , we discuss the molecular mechanisms that regulate [programmed cell death] *induced* by disruption of the complex and consider the wider implications these findings have for the future development of novel chemotherapeutic agents . Negative_regulation PDCD4 CLU 10854058 704199 These findings indicate that depletion of can *lead* to the [programmed cell death] in ovary , suggesting a functional role for this protein in follicular atresia . Negative_regulation PDCD4 CLU 22358960 178186 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Negative_regulation PDCD4 FAS 1689786 128389 Binding of to cells expressing APO-1 *results* in [programmed cell death] , apoptosis , the most common form of death in eukaryotic cells . Negative_regulation PDCD4 FAS 8758891 377809 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Negative_regulation PDCD4 FAS 9177220 434092 In addition to providing costimulatory signals for cell proliferation , ligation of both TNFR1 and can *result* in [programmed cell death] or apoptosis . Negative_regulation PDCD4 FAS 9188860 437478 Regulation of dependent activation induced T cell apoptosis by cAMP signaling : a potential role for transcription factor NF-kappa B . TCR mediated activation of T cell hybridomas *induces* [programmed cell death] by a Fas dependent pathway . Negative_regulation PDCD4 IL1B 1993844 154222 Lipopolysaccharide , tumor necrosis factor-alpha , and *prevent* [programmed cell death] ( apoptosis ) in human peripheral blood monocytes . Negative_regulation PDCD4 IL1B 9670975 519737 Since an antisense oligonucleotide for IL-1 beta , a blocking Ab to IL-1 beta , and preincubation with the IL-1R antagonist all prevent the delay in apoptosis , we conclude that acts in an autocrine manner to *inhibit* granulocyte [programmed cell death] . Negative_regulation PDCD4 TNF 1993844 154221 Lipopolysaccharide , , and IL-1 beta *prevent* [programmed cell death] ( apoptosis ) in human peripheral blood monocytes . Negative_regulation PDCD4 TNF 20832854 2325312 It is thus suggested that the co-immobilized TNF-a plus IFN-? promotes the activation of some unknown key markers in response to IFN-? , and the binding of the co-immobilized plus IFN-? with some other TNF-a receptors *results* in enhanced [programmed cell death] in HeLa cells . Negative_regulation PDCD4 TNF 8758891 377808 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Negative_regulation PDCD5 CAPN8 10825507 696572 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Negative_regulation PDCD5 CCND1 17525529 1751396 Here , we discuss the molecular mechanisms that regulate [programmed cell death] *induced* by disruption of the complex and consider the wider implications these findings have for the future development of novel chemotherapeutic agents . Negative_regulation PDCD5 CLU 10854058 704200 These findings indicate that depletion of can *lead* to the [programmed cell death] in ovary , suggesting a functional role for this protein in follicular atresia . Negative_regulation PDCD5 CLU 22358960 178187 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Negative_regulation PDCD5 FAS 1689786 128390 Binding of to cells expressing APO-1 *results* in [programmed cell death] , apoptosis , the most common form of death in eukaryotic cells . Negative_regulation PDCD5 FAS 8758891 377811 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Negative_regulation PDCD5 FAS 9177220 434094 In addition to providing costimulatory signals for cell proliferation , ligation of both TNFR1 and can *result* in [programmed cell death] or apoptosis . Negative_regulation PDCD5 FAS 9188860 437479 Regulation of dependent activation induced T cell apoptosis by cAMP signaling : a potential role for transcription factor NF-kappa B . TCR mediated activation of T cell hybridomas *induces* [programmed cell death] by a Fas dependent pathway . Negative_regulation PDCD5 IL1B 1993844 154224 Lipopolysaccharide , tumor necrosis factor-alpha , and *prevent* [programmed cell death] ( apoptosis ) in human peripheral blood monocytes . Negative_regulation PDCD5 IL1B 9670975 519738 Since an antisense oligonucleotide for IL-1 beta , a blocking Ab to IL-1 beta , and preincubation with the IL-1R antagonist all prevent the delay in apoptosis , we conclude that acts in an autocrine manner to *inhibit* granulocyte [programmed cell death] . Negative_regulation PDCD5 TNF 1993844 154223 Lipopolysaccharide , , and IL-1 beta *prevent* [programmed cell death] ( apoptosis ) in human peripheral blood monocytes . Negative_regulation PDCD5 TNF 20832854 2325313 It is thus suggested that the co-immobilized TNF-a plus IFN-? promotes the activation of some unknown key markers in response to IFN-? , and the binding of the co-immobilized plus IFN-? with some other TNF-a receptors *results* in enhanced [programmed cell death] in HeLa cells . Negative_regulation PDCD5 TNF 8758891 377810 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Negative_regulation PDCD6 CAPN8 10825507 696586 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Negative_regulation PDCD6 CCND1 17525529 1751398 Here , we discuss the molecular mechanisms that regulate [programmed cell death] *induced* by disruption of the complex and consider the wider implications these findings have for the future development of novel chemotherapeutic agents . Negative_regulation PDCD6 CLU 10854058 704201 These findings indicate that depletion of can *lead* to the [programmed cell death] in ovary , suggesting a functional role for this protein in follicular atresia . Negative_regulation PDCD6 CLU 22358960 178188 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Negative_regulation PDCD6 FAS 1689786 128391 Binding of to cells expressing APO-1 *results* in [programmed cell death] , apoptosis , the most common form of death in eukaryotic cells . Negative_regulation PDCD6 FAS 8758891 377813 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Negative_regulation PDCD6 FAS 9177220 434096 In addition to providing costimulatory signals for cell proliferation , ligation of both TNFR1 and can *result* in [programmed cell death] or apoptosis . Negative_regulation PDCD6 FAS 9188860 437480 Regulation of dependent activation induced T cell apoptosis by cAMP signaling : a potential role for transcription factor NF-kappa B . TCR mediated activation of T cell hybridomas *induces* [programmed cell death] by a Fas dependent pathway . Negative_regulation PDCD6 IL1B 1993844 154226 Lipopolysaccharide , tumor necrosis factor-alpha , and *prevent* [programmed cell death] ( apoptosis ) in human peripheral blood monocytes . Negative_regulation PDCD6 IL1B 9670975 519739 Since an antisense oligonucleotide for IL-1 beta , a blocking Ab to IL-1 beta , and preincubation with the IL-1R antagonist all prevent the delay in apoptosis , we conclude that acts in an autocrine manner to *inhibit* granulocyte [programmed cell death] . Negative_regulation PDCD6 TNF 1993844 154225 Lipopolysaccharide , , and IL-1 beta *prevent* [programmed cell death] ( apoptosis ) in human peripheral blood monocytes . Negative_regulation PDCD6 TNF 20832854 2325314 It is thus suggested that the co-immobilized TNF-a plus IFN-? promotes the activation of some unknown key markers in response to IFN-? , and the binding of the co-immobilized plus IFN-? with some other TNF-a receptors *results* in enhanced [programmed cell death] in HeLa cells . Negative_regulation PDCD6 TNF 8758891 377812 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Negative_regulation PDCD7 CAPN8 10825507 696600 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Negative_regulation PDCD7 CCND1 17525529 1751400 Here , we discuss the molecular mechanisms that regulate [programmed cell death] *induced* by disruption of the complex and consider the wider implications these findings have for the future development of novel chemotherapeutic agents . Negative_regulation PDCD7 CLU 10854058 704202 These findings indicate that depletion of can *lead* to the [programmed cell death] in ovary , suggesting a functional role for this protein in follicular atresia . Negative_regulation PDCD7 CLU 22358960 178189 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Negative_regulation PDCD7 FAS 1689786 128392 Binding of to cells expressing APO-1 *results* in [programmed cell death] , apoptosis , the most common form of death in eukaryotic cells . Negative_regulation PDCD7 FAS 8758891 377815 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Negative_regulation PDCD7 FAS 9177220 434098 In addition to providing costimulatory signals for cell proliferation , ligation of both TNFR1 and can *result* in [programmed cell death] or apoptosis . Negative_regulation PDCD7 FAS 9188860 437481 Regulation of dependent activation induced T cell apoptosis by cAMP signaling : a potential role for transcription factor NF-kappa B . TCR mediated activation of T cell hybridomas *induces* [programmed cell death] by a Fas dependent pathway . Negative_regulation PDCD7 IL1B 1993844 154228 Lipopolysaccharide , tumor necrosis factor-alpha , and *prevent* [programmed cell death] ( apoptosis ) in human peripheral blood monocytes . Negative_regulation PDCD7 IL1B 9670975 519740 Since an antisense oligonucleotide for IL-1 beta , a blocking Ab to IL-1 beta , and preincubation with the IL-1R antagonist all prevent the delay in apoptosis , we conclude that acts in an autocrine manner to *inhibit* granulocyte [programmed cell death] . Negative_regulation PDCD7 TNF 1993844 154227 Lipopolysaccharide , , and IL-1 beta *prevent* [programmed cell death] ( apoptosis ) in human peripheral blood monocytes . Negative_regulation PDCD7 TNF 20832854 2325315 It is thus suggested that the co-immobilized TNF-a plus IFN-? promotes the activation of some unknown key markers in response to IFN-? , and the binding of the co-immobilized plus IFN-? with some other TNF-a receptors *results* in enhanced [programmed cell death] in HeLa cells . Negative_regulation PDCD7 TNF 8758891 377814 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Negative_regulation PDE4A EPHB2 20600853 2290880 The protein kinase C inhibitors , RO 320432 and GO 6983 , and the inhibitors UO 126 and PD 98059 all *activated* [PDE4A4] aggregate formation , whilst roscovitine , thalidomide and the tyrosine kinase inhibitors , genistein and AG17 , all inhibited this process . Negative_regulation PDE4B IL10 10385698 625679 Very recently , we found in monocytes that [PDE4B] gene expression is selectively induced by lipopolysaccharide (LPS) and that the induction is *inhibited* by and IL-4 . Negative_regulation PDE4B IL10 9882697 584284 We also demonstrate that LPS induction of [PDE4B] mRNA expression was *inhibited* strongly by . Negative_regulation PDE4B IL10 9882697 584285 Interestingly , unlike LPS induction , the dibutyryl-cAMP induction of [PDE4B] mRNA expression was not *inhibited* by . Negative_regulation PDE4B IL10 9882697 584286 By performing nuclear run-on and mRNA stability assays , we demonstrate further that *inhibited* LPS stimulated [PDE4B] mRNA synthesis by abolishing the gene transcription rather than by enhancing mRNA degradation . Negative_regulation PDE4B IL4 10385698 625680 Very recently , we found in monocytes that [PDE4B] gene expression is selectively induced by lipopolysaccharide (LPS) and that the induction is *inhibited* by interleukin (IL)-10 and . Negative_regulation PDE5A BRAF 21215707 2379294 Thus , we show that in melanoma cells oncogenic *induces* invasion through downregulation of [PDE5A] . Negative_regulation PDE5A NOS3 22230399 2519470 KMUP-1 ( 0.001-0.1 microM ) concentration dependently increased in normoxia and did not *inhibit* [phosphodiesterase-5A (PDE-5A)] in hypoxic cells . Negative_regulation PDE5A STIL 19130990 2025321 *inhibits* cyclic guanosine monophosphate-specific [PDE5A] and can blunt the evolution of cardiac hypertrophy and dysfunction in mice subjected to pressure overload . Negative_regulation PDGFA EPHB2 21824285 2485340 Epinephrine enhanced S. sanguinis induced platelet aggregation and phosphorylation of phospholipase C?2 and , but *inhibited* RANTES , PF4 , sCD40L and [PDGF-AB] release . Negative_regulation PDGFA IL1B 10807932 708057 The *induced* increase in the number of ( 125 ) [I-PDGF-AA] binding sites at the cell surface was reduced > 70 % by pretreatment with SB203580 . Negative_regulation PDGFA IL1B 1767825 174820 significantly *reduced* [PDGF-AA] binding and significantly decreased both PDGF-AA mediated cell migration and thymidine incorporation . Negative_regulation PDGFA IL1B 7747636 306508 *inhibits* [PDGF-AA] induced autophosphorylation by down-regulation of the PDGF-alpha receptor , as demonstrated by immunoprecipitation experiments . Negative_regulation PDGFA TNF 8557767 347660 We now report that significantly *reduces* [PDGF-AA] binding by decreasing the number of PDGF-alpha receptor subunits on the surface of normal human osteoblastic cells . Negative_regulation PDGFB EPHB2 21824285 2485341 Epinephrine enhanced S. sanguinis induced platelet aggregation and phosphorylation of phospholipase C?2 and , but *inhibited* RANTES , PF4 , sCD40L and [PDGF-AB] release . Negative_regulation PDGFB MAP2K6 10753966 682512 In contrast , the inhibitor *had* no effect on the activity of the mutant [PDGF-B] promoter . Negative_regulation PDGFC EPHB2 15247255 1295853 Moreover , using pharmacological inhibitors we demonstrate the critical *role* of but not JNK in FGF-2-inducible [PDGF-C] expression . Negative_regulation PDGFD IL1B 19843519 2170115 [PDGF-D] *repression* by involves histone deacetylation and interaction of HDAC-1 with IRF-1 and p65 . Negative_regulation PDGFRA IL1B 14766209 1207530 In the current study , we found that could *inhibit* the [PDGFRalpha] gene promoter activity , and this effect was strongly correlated with increased binding of CCAAT/enhancer binding protein (C/EBP) to the responsive promoter region . Negative_regulation PDGFRB EPHB2 24096267 2902754 The anti-tumor effect of sorafenib is thought to be mediated through its inhibition of the pathway , as well as its *inhibition* of VEGFR and [PDGFR] . Negative_regulation PDHX TNF 9450646 475466 and IL-1 alpha *inhibit* both [pyruvate dehydrogenase] activity and mitochondrial function in cardiomyocytes : evidence for primary impairment of mitochondrial function . Negative_regulation PDR PLAT 25349789 2959843 To investigate the *role* of and plasminogen activator inhibitor (PAI) in [proliferative diabetic retinopathy (PDR)] and to discuss the correlations among t-PA , PAI and vascular endothelial growth factor ( VEGF ) expressions . Negative_regulation PDX1 FOXO1 12488434 1025915 We propose that insulin/IGFs regulate beta cell proliferation by relieving *inhibition* of [Pdx1] expression in a subset of cells embedded within pancreatic ducts . Negative_regulation PDX1 FOXO1 16282329 1509484 Furthermore , adenovirus mediated overexpression *reduced* the nuclear expression of [PDX-1] , whereas repression of Foxo1 by Foxo1-specific small interfering RNA retained the nuclear expression of PDX-1 under oxidative stress conditions . Negative_regulation PDX1 FOXO1 20353756 2244940 On the contrary , the forkhead transcription factor *inhibits* [PDX-1] gene transcription . Negative_regulation PDX1 FOXO1 20649634 2293143 Moreover , hIAPP induced but *inhibited* [pdx-1] nucleus translocation . Negative_regulation PDX1 FOXO1 21335550 2411102 We conclude that nuclear import of *contributes* to the suppression of [Pdx1] and Ins2 gene expression at low glucose , the latter via a previously unsuspected and direct physical interaction with the Ins2 promoter . Negative_regulation PDX1 IL1B 20424162 2274554 also *causes* increased expression of C/EBP-beta and a reduction of MafA , NFATc2 , and [Pdx-1] expression in beta cells . Negative_regulation PDX1 PGC 23274887 2758061 More precisely , *inhibited* the expression of the key ß-cell transcription factor [pancreatic duodenal homeobox 1 (Pdx1)] . Negative_regulation PEBP1 EPHB2 10490027 645416 Downregulation of endogenous [RKIP] by expression of antisense RNA or antibody microinjection *induces* the activation of MEK- , and AP-1 dependent transcription . Negative_regulation PEBP1 EPHB2 15155742 1273256 Although the protein amount of ERK was not altered , phosphorylated levels were decreased and cell proliferation was partly *inhibited* by [PEBP] expression . Negative_regulation PEBP1 EPHB2 20736375 2313458 In particular , we made two important findings : first , that coupled positive feedback loops composed of phosphorylation of Raf kinase inhibitor RKIP by and transcriptional *repression* of [RKIP] by Snail have an essential role in causing a switch-like behavior of E-cadherin expression ; Negative_regulation PEBP1 IL1B 8431204 212784 Stimulation of synovial cells with recombinant *induced* a decrease in phosphatidylcholine ( PC ) , phosphatidylinositol ( PI ) , and [phosphatidylethanolamine (PE)] , and a marked increase in cell associated PLA2 activity as compared with controls . Negative_regulation PEBP4 EPHB2 15155742 1273255 Although the protein amount of ERK was not altered , phosphorylated levels were decreased and cell proliferation was partly *inhibited* by [PEBP] expression . Negative_regulation PEBP4 IL1B 8431204 212783 Stimulation of synovial cells with recombinant *induced* a decrease in phosphatidylcholine ( PC ) , phosphatidylinositol ( PI ) , and [phosphatidylethanolamine (PE)] , and a marked increase in cell associated PLA2 activity as compared with controls . Negative_regulation PECAM1 AKT1 15985432 1441189 Tie2 and [PECAM1] expression decreased > 80 % after siRNA treatment , and flow stimulated phosphorylation of ERK1/2 , , and endothelial nitric oxide synthase was significantly *inhibited* by Tie2 and PECAM1 siRNA . Negative_regulation PECAM1 AKT2 15985432 1441190 Tie2 and [PECAM1] expression decreased > 80 % after siRNA treatment , and flow stimulated phosphorylation of ERK1/2 , , and endothelial nitric oxide synthase was significantly *inhibited* by Tie2 and PECAM1 siRNA . Negative_regulation PECAM1 AKT3 15985432 1441191 Tie2 and [PECAM1] expression decreased > 80 % after siRNA treatment , and flow stimulated phosphorylation of ERK1/2 , , and endothelial nitric oxide synthase was significantly *inhibited* by Tie2 and PECAM1 siRNA . Negative_regulation PECAM1 ANGPT1 19245790 2050728 Moreover , *restored* the level of [PECAM-1] expression , which is significantly reduced by endotoxin challenge . Negative_regulation PECAM1 CASP3 22130238 2515141 These decreases in [CD31] and CD47 levels on the apoptotic cell surface were almost completely *suppressed* by the inhibitor , Ac-DEVD-CHO , and partially suppressed by caspase 8 ( Ac-IETD-CHO ) and caspase 9 ( Ac-LEHE-CHO ) inhibitors but not by the metalloproteinase inhibitors GM6001 and TAPI-0 . Negative_regulation PECAM1 COMP 19245790 2050727 Moreover , *restored* the level of [PECAM-1] expression , which is significantly reduced by endotoxin challenge . Negative_regulation PECAM1 IFNG 18466611 1916544 The early decrease of [PECAM-1-expression] and the parallel increase of ICAM-1-expression following CCl4-treatment is *induced* by elevated levels of in livers and may facilitate adhesion and transmigration of inflammatory cells . Negative_regulation PECAM1 MAPK3 15985432 1441192 Tie2 and [PECAM1] expression decreased > 80 % after siRNA treatment , and flow stimulated phosphorylation of , Akt , and endothelial nitric oxide synthase was significantly *inhibited* by Tie2 and PECAM1 siRNA . Negative_regulation PECAM1 NOS1 15985432 1441193 Tie2 and [PECAM1] expression decreased > 80 % after siRNA treatment , and flow stimulated phosphorylation of ERK1/2 , Akt , and endothelial was significantly *inhibited* by Tie2 and PECAM1 siRNA . Negative_regulation PECAM1 NOS2 15985432 1441194 Tie2 and [PECAM1] expression decreased > 80 % after siRNA treatment , and flow stimulated phosphorylation of ERK1/2 , Akt , and endothelial was significantly *inhibited* by Tie2 and PECAM1 siRNA . Negative_regulation PECAM1 NOS3 15985432 1441195 Tie2 and [PECAM1] expression decreased > 80 % after siRNA treatment , and flow stimulated phosphorylation of ERK1/2 , Akt , and endothelial was significantly *inhibited* by Tie2 and PECAM1 siRNA . Negative_regulation PECAM1 PCNA 16317135 1487603 The GTPs+UVB group also had reduced expressions of [CD31] and vascular endothelial growth factor , which are essential for angiogenesis , and *inhibited* expression of in the tumors compared with the UVB group . Negative_regulation PECAM1 PTPN11 20631249 2321909 We observed that the levels of PECAM-1 tyrosine phosphorylation and SHP-2 association with PECAM-1 were significantly increased in cells expressing a phosphatase-inactive SHP-2 mutant , suggesting that the level of [PECAM-1] tyrosine phosphorylation , and thus SHP-2 binding are *regulated* in part by bound , catalytically active . Negative_regulation PECAM1 RUNX3 23370707 2770713 Our results indicate that VEGF , vWF , [CD31] , pSmad2 , NF-kB , WT-1 and Thy-1 were markedly *up-regulated* by the loss of . Negative_regulation PECAM1 TGFB1 19729486 2147079 Confocal microscopy and real-time PCR showed that *induced* de novo expression of alpha-SMA and loss of expression of VE-cadherin and [CD31] in MMECs and primary cultures of renal endothelial cells in a time- and dose dependent fashion . Negative_regulation PECAM1 TIE1 15985432 1441188 Tie2 and [PECAM1] expression decreased > 80 % after siRNA treatment , and flow stimulated phosphorylation of ERK1/2 , Akt , and endothelial nitric oxide synthase was significantly *inhibited* by and PECAM1 siRNA . Negative_regulation PECAM1 TYR 12775720 1119792 Inhibition of ( vanadate ) *increases* Tyr phosphorylated [PECAM-1] and blocks the activation of p38MAPK . Negative_regulation PECAM1 VEGFA 15938647 1473445 With respect to the tumor vasculature , EGCG decreased the expression of [CD31] , a cell surface marker of vascular endothelial cells , and *inhibited* the expression of in tumors , which are essential for angiogenesis . Negative_regulation PEPD ARSA 15337432 1291345 In order to limit the action of prolidase on the pro-drug in normal cells , [prolidase] *inhibitor* , , was tested in fibroblasts ( showing average prolidase activity for normal cells ) and in MDA-MB 231 breast cancer cells ( showing elevated activity of the enzyme ) . Negative_regulation PER1 TFPI2 16790549 1585806 Expression of a dominant negative mutant *reduces* [PER] phosphorylation by CKIepsilon in vivo , and down-regulation of PP5 significantly reduces the amplitude of circadian cycling in cultured human fibroblasts . Negative_regulation PER1 TNF 18480551 1910670 Here , we show that *suppressed* the expression of both [Per1] and Per3 in MIA-PaCa2 cells , a human pancreatic cancer cell line . Negative_regulation PER1 TNF 19625730 2112694 Interaction of with TNFR1 ( Tnfrsf1a , CD120a , p55 ) , but not TNFR2 ( Tnfrsf1b , CD120b , p75 ) , *leads* to fast downregulation of gene expression of Dbp and upregulation of negative regulators of the molecular clock , [Per1] and Per2 , Cryptochrome-1 (Cry1) , and Differentiated embryo chondrocytes-1 ( Dec1 ) . Negative_regulation PER2 TNF 23496259 2803951 However , *inhibited* the mRNA expression of the [Per2] gene , as well as Dbp , Hlf , and Tef , but enhanced the mRNA expression of E4bp4 . Negative_regulation PER2 TNF 23496259 2803953 Furthermore , *inhibited* the transcriptional activity of the wild-type [Per2] gene in a manner dependent on the D-box 1 and D-box 2 motifs in the Per2 promoter . Negative_regulation PER3 TNF 18480551 1910671 Here , we show that *suppressed* the expression of both Per1 and [Per3] in MIA-PaCa2 cells , a human pancreatic cancer cell line . Negative_regulation PF4 EPHB2 21824285 2485342 Epinephrine enhanced S. sanguinis induced platelet aggregation and phosphorylation of phospholipase C?2 and , but *inhibited* RANTES , [PF4] , sCD40L and PDGF-AB release . Negative_regulation PGC A2M 14506912 1145009 The activities of pepsin and [gastricsin] towards a protein substrate ( reduced and carboxymethylated ribonuclease A ) were significantly *inhibited* by at pH 5.5 , whereas those towards a peptide substrate ( oxidized insulin B-chain ) were scarcely inhibited . Negative_regulation PGC ACACA 21803289 2462272 Deletion of mIndy in mice ( mINDY ( -/- ) mice ) reduces hepatocellular ATP/ADP ratio , activates hepatic AMPK , induces [PGC-1a] , *inhibits* , and reduces SREBP-1c levels . Negative_regulation PGC ACVR2B 22586266 2619582 Mechanistically , inhibition of inhibits Smad3 signaling and *activates* the expression of myoglobin and [PGC-1] coregulators in brown adipocytes . Negative_regulation PGC ATF4 22980225 2726679 We have shown previously that the expression of peroxisome proliferator activated receptor gamma coactivator ( PGC1a ) increases significantly in the white and brown adipose tissue of activating transcription factor 4 ( ATF4 ) global knockout mice , which suggests that is *involved* in the regulation of [PGC1a] expression . Negative_regulation PGC CADM1 14627720 1176390 We found that the expression of a calcium dependent , E-cadherin , is restricted to the proximal region of extra-embryonic mesoderm that contains PGC precursors , and that blocking the functions of E-cadherin with an antibody *inhibits* [PGC] formation in vitro . Negative_regulation PGC CADM2 14627720 1176388 We found that the expression of a calcium dependent , E-cadherin , is restricted to the proximal region of extra-embryonic mesoderm that contains PGC precursors , and that blocking the functions of E-cadherin with an antibody *inhibits* [PGC] formation in vitro . Negative_regulation PGC CADM3 14627720 1176387 We found that the expression of a calcium dependent , E-cadherin , is restricted to the proximal region of extra-embryonic mesoderm that contains PGC precursors , and that blocking the functions of E-cadherin with an antibody *inhibits* [PGC] formation in vitro . Negative_regulation PGC CADM4 14627720 1176389 We found that the expression of a calcium dependent , E-cadherin , is restricted to the proximal region of extra-embryonic mesoderm that contains PGC precursors , and that blocking the functions of E-cadherin with an antibody *inhibits* [PGC] formation in vitro . Negative_regulation PGC CDH1 14627720 1176386 We found that the expression of a calcium dependent cell adhesion molecule , , is restricted to the proximal region of extra-embryonic mesoderm that contains PGC precursors , and that blocking the functions of E-cadherin with an antibody *inhibits* [PGC] formation in vitro . Negative_regulation PGC CDK9 15297879 1290406 Activation of cardiac *represses* [PGC-1] and confers a predisposition to heart failure . Negative_regulation PGC EIF4EBP1 23672244 2801065 In 4E-BP1 ( -/- ) MEF cells , PPAR? coactivator 1 alpha ( PGC-1a ) expression increased and exogenous <4E-BP1> expression *suppressed* [PGC-1a] expression . Negative_regulation PGC EIF4EBP1 23672244 2801066 Moreover , the ectopic over-expression of <4E-BP1> *suppressed* [PGC-1a] expression in white adipocytes , but not in brown adipocytes . Negative_regulation PGC EIF4EBP1 23672244 2801067 Thus , the results of our study indicate that <4E-BP1> may *suppress* brown adipocyte differentiation and [PGC-1a] expression in white adipose tissues . Negative_regulation PGC FOXO6 23639108 2805058 We further demonstrated that *represses* the expression of [PGC-1a] via direct binding to an upstream A/T-rich element ( AAGATATCAAAACA , -2228-2215 ) in the PGC-1a promoter . Negative_regulation PGC HDAC5 23668787 2785053 has previously been demonstrated to strongly *inhibit* expression of [PGC-1a] , and we show that overexpression of ERRa is sufficient to overcome this repressive effect . Negative_regulation PGC HTT 21715619 2447227 Importantly , expression of mutant in primary oligodendrocytes *resulted* in decreased expression of [PGC1a] and its targets HmgcS1 , Hmgcr , and MBP . Negative_regulation PGC INS 21156859 2390431 The p38 MAPK induced [PGC-1a] gene transcription was *prevented* by . Negative_regulation PGC KITLG 1715517 164994 Using an in vitro assay system , we show that *increases* both the overall numbers and colony sizes of migratory [PGC] isolated from wild-type mouse embryos , and cultured on irradiated feeder layers of STO cells ( a mouse embryonic fibroblast line ) . Negative_regulation PGC MAOA 22738191 2715434 We provide the first evidence that upregulation in the heart *causes* oxidative mitochondrial damage , p53 dependent repression of [PGC-1a] , cardiomyocyte necrosis , and chronic ventricular dysfunction . Negative_regulation PGC MUC5AC 12843612 1108521 The injection of hydrocortisone *induced* [PgC] mRNA expression in the infant rat stomach , whereas and PgF mRNA expression decreased . Negative_regulation PGC MYBBP1A 24216763 2892154 Prep1 stabilizes p160 , a known *inhibitor* of [PGC-1a] activity . Negative_regulation PGC MYLIP 23111009 2740600 In contrast , loss of function in primary hepatocytes *increased* the protein levels of [PGC-1a] and G6Pase and increased cellular glucose production . Negative_regulation PGC NQO1 23648480 2795908 We further demonstrate that [PGC-1a] degradation is *inhibited* by , a 20S gatekeeper protein . Negative_regulation PGC NRF1 22586274 2619656 We discovered that the deficiency *leads* to the reduced expression of the transcriptional coactivator genes Lipin1 and [PGC-1ß] ( for peroxisome proliferator activated receptor ? coactivator 1ß ) . Negative_regulation PGC PGF 12843612 1108522 The injection of hydrocortisone *induced* [PgC] mRNA expression in the infant rat stomach , whereas MUC5AC and mRNA expression decreased . Negative_regulation PGC PIK3CA 21054343 2376351 As NRF1 and NRF2 are under the transcriptional control of peroxisome proliferator activated receptor ? coactivators-1a and -1ß ( PGC-1a and PGC-1ß ) , we found that suppressing activity selectively *reduced* both the mRNA and protein levels of [PGC-1ß] but not PGC-1a . Negative_regulation PGC PIK3R1 21054343 2376352 As NRF1 and NRF2 are under the transcriptional control of peroxisome proliferator activated receptor ? coactivators-1a and -1ß ( PGC-1a and PGC-1ß ) , we found that suppressing activity selectively *reduced* both the mRNA and protein levels of [PGC-1ß] but not PGC-1a . Negative_regulation PGC PRKAA1 16364253 1504747 Here we show that activation by 5-aminoimidazole-4-carboxamide ribonucleoside ( AICAR ) *increases* mRNA expression of PPARalpha target genes and PGC-1 in cultured muscle cells and mouse skeletal muscle , and that inhibition of PPARalpha and [PGC-1] by siRNAs prevents AICAR stimulated increase in fatty acid oxidation . Negative_regulation PGC PRKAA2 16364253 1504748 Here we show that activation by 5-aminoimidazole-4-carboxamide ribonucleoside ( AICAR ) *increases* mRNA expression of PPARalpha target genes and PGC-1 in cultured muscle cells and mouse skeletal muscle , and that inhibition of PPARalpha and [PGC-1] by siRNAs prevents AICAR stimulated increase in fatty acid oxidation . Negative_regulation PGC PRKAB1 16364253 1504749 Here we show that activation by 5-aminoimidazole-4-carboxamide ribonucleoside ( AICAR ) *increases* mRNA expression of PPARalpha target genes and PGC-1 in cultured muscle cells and mouse skeletal muscle , and that inhibition of PPARalpha and [PGC-1] by siRNAs prevents AICAR stimulated increase in fatty acid oxidation . Negative_regulation PGC PRKAB2 16364253 1504750 Here we show that activation by 5-aminoimidazole-4-carboxamide ribonucleoside ( AICAR ) *increases* mRNA expression of PPARalpha target genes and PGC-1 in cultured muscle cells and mouse skeletal muscle , and that inhibition of PPARalpha and [PGC-1] by siRNAs prevents AICAR stimulated increase in fatty acid oxidation . Negative_regulation PGC PRKAG1 16364253 1504751 Here we show that activation by 5-aminoimidazole-4-carboxamide ribonucleoside ( AICAR ) *increases* mRNA expression of PPARalpha target genes and PGC-1 in cultured muscle cells and mouse skeletal muscle , and that inhibition of PPARalpha and [PGC-1] by siRNAs prevents AICAR stimulated increase in fatty acid oxidation . Negative_regulation PGC PRKAG2 16364253 1504752 Here we show that activation by 5-aminoimidazole-4-carboxamide ribonucleoside ( AICAR ) *increases* mRNA expression of PPARalpha target genes and PGC-1 in cultured muscle cells and mouse skeletal muscle , and that inhibition of PPARalpha and [PGC-1] by siRNAs prevents AICAR stimulated increase in fatty acid oxidation . Negative_regulation PGC RBBP8 17089023 1644234 We further demonstrated that the overexpression of *resulted* in changes in the expression of the [PGC-1] responsive gene , fatty acid synthase (FAS) . Negative_regulation PGC REN 8257128 238550 Human pepsin and [gastricsin] were inhibited with Kis of 8 and 500 nM , respectively , and human was *inhibited* with a Ki of 190 microM . Negative_regulation PGC RNF19A 22510382 2601985 ERK and inhibitors attenuate memory deficits and *increase* CREB phosphorylation and [PGC-1a] levels in Aß-injected rats . Negative_regulation PGC SIRT1 23710679 2811445 As compared with I/R injury group , CR further increased kidney expression by 1.8-fold , *promoted* autophagy and counteracted I/R induced decreases in the expression of eNOS and [PGC-1a] . Negative_regulation PGC SIRT1 23874150 2817739 Knockdown of SIRT1 , or suppression of activity with a dominant negative ( DN ) SIRT1 construct , *increased* PGC-1a acetylation , [PGC-1a] coactivator activity , and mitochondrial proteins in C2C12 cells . Negative_regulation PGC SREBF1 14722127 1219727 Estimation of coactivator recruitment using HNF-4alpha-Gal4DBD fusion assay showed that competitively *inhibited* [PGC-1] recruitment , a requirement for HNF-4alpha activation . Negative_regulation PGC SREBF2 20926756 2364721 In pull-down assays and coimmunoprecipitation assays , bound to peroxisome proliferator activated receptor ? coactivator-1a ( PGC-1a ) , a major coactivator for HNF-4a , via its transactivation domain and *inhibited* the interaction between HNF-4a and [PGC-1a] in vitro . Negative_regulation PGC TNF 23563317 2794480 In line with in vitro data , NF-?B blockade in vivo abrogated *induced* reductions in [PGC-1a] expression . Negative_regulation PGC TNFSF12 23342071 2733889 *induced* downregulation of [PGC1a] requires expression of its cell surface receptor , fibroblast growth factor-inducible 14 ( Fn14 ) . Negative_regulation PGC TNFSF12 24327607 2916920 Here we demonstrate that significantly *reduces* the levels of [PGC-1a] and mitochondrial content ( ~50 % ) in skeletal muscle . Negative_regulation PGC TP53 22738191 2715433 We provide the first evidence that MAO-A upregulation in the heart causes oxidative mitochondrial damage , *dependent* repression of [PGC-1a] , cardiomyocyte necrosis , and chronic ventricular dysfunction . Negative_regulation PGC USF1 12611894 1085410 However , overexpression of the proteins in myocytes depresses CPT-1beta activity and significantly *reduces* MEF2A and [PGC-1] synergy . Negative_regulation PGC USF2 12611894 1085411 However , overexpression of the proteins in myocytes depresses CPT-1beta activity and significantly *reduces* MEF2A and [PGC-1] synergy . Negative_regulation PGC WAS 24949658 2952339 d ( 9 ) <-THC> also *blocked* the PVH effect of MTII on ( 14 ) C-bromopalmitate uptake as well as on [Pgc1a] and Dio2 expression in iBAT . Negative_regulation PGC XPO1 24081905 2888598 Akt3 knockdown and overexpression *cause* 3-fold reductions in [PGC-1a] target gene expression , compared to control levels . Negative_regulation PGD ADRB2 15467193 1305759 Furthermore , the desensitization *causes* differential attenuating effects on the inhibition of histamine , [PGD2] , and LT release , suggesting that downstream events involved in each inhibitory pathway have different sensitivity to receptor desensitization . Negative_regulation PGD ARSA 1309968 178462 also *inhibited* [PGD2] release in insensitive asthmatic patients but not in both sensitive patients and healthy subjects . Negative_regulation PGD TNF 24446972 2918161 Homoisoflavanone down-regulated [PGD2] , LTB4 , and LTC4 production and *inhibited* the production of pro-inflammatory cytokines , such as interleukin-6 and in PMA/A23187- or IgE/antigen stimulated mast cells . Negative_regulation PGF ARSA 12429581 1014946 Leucocyte [6-keto-PGF] ( 1alpha ) was *inhibited* by ( IC ( 50 ) 6.58+/-0.76 micro M ) and increased by dazoxiben and DT-TX 30 . Negative_regulation PGF ARSA 17259075 1691232 ( 50 mg/kg and 200 mg/kg , but not 10 mg/kg ) augmented the LPS effect on 15-epi-LXA4 but *attenuated* the effect on [6-keto-PGF] ( 1alpha ) . Negative_regulation PGF ARSA 3248102 103850 and AR 12456 completely eliminated the second blood pressure depression after injection of AA and simultaneously *diminished* TXA2 , TXB2 and [6-keto-PGF1a] formation in murine blood , whereas BM 13177 prevented the return of the blood pressure to preinjection level after the initial brief fall in arterial pressure . Negative_regulation PGF ARSA 8217777 231717 + DPM significantly *reduced* arterial [6-keto-PGF1a] although this was marginally increased by CGS12970 . Negative_regulation PGF IL1B 9820830 548056 The presence of superoxide dismutase ( SOD , 100 units/ml ) or the NOS synthase inhibitor Nomega-monomethyl-l-arginine ( 100 microM ) as well as cycloheximide ( 10 microM ) plus actinomycin ( 10 microM ) abolished *mediated* down-regulation of [6-oxo-PGF1alpha] from PGH2 . Negative_regulation PGF SLCO2A1 20410207 2274292 Pharmacological inhibition of prevented transport of exogenous [ ( 3 ) H ] PGF ( 2alpha ) as well as oxytocin *induced* endogenous luteolytic [PGF] ( 2alpha ) pulse up to 80 % from uterine venous blood into ovarian arterial blood through the UOP at the time of luteolysis in sheep . Negative_regulation PGF TNF 10775156 686507 Cultured bovine epithelial and stromal cells were exposed to TNFalpha ( 0.006-6 nM ) or oxytocin ( 100 nM ) for 4 h . *resulted* in a dose dependent increase of [PGF] ( 2alpha ) production in the stromal cells ( P < 0.001 ) but not in the epithelial cells . Negative_regulation PGF TNF 12024109 944240 Administration of capsaicin and CGRP significantly enhanced I/R induced increases in hepatic levels of [6-keto-PGF] ( 1alpha ) , increased hepatic-tissue blood flow after reperfusion , and *inhibited* the I/R induced increase in tissue levels of both and myeloperoxidase . Negative_regulation PGF TNF 15950430 1427644 in combination with interferon-gamma *reduced* progesterone ( P4 ) secretion , increased [PGF2alpha] and leukotriene C4 ( LTC4 ) production , and induced apoptosis of the luteal cells in vitro . Negative_regulation PGF TNF 16595720 1544680 *reduced* DMalpha mRNA concentrations in cultured luteal cells in the presence of LH or [PGF] ( 2alpha ) . Negative_regulation PGF TNF 19471094 2085353 Ang II and LPS stimulated secretion and *inhibited* [6-keto-PGF] ( 1alpha ) production , upregulated MMP-9 and downregulated PPARgamma and PPARalphain rat VSMCs . Negative_regulation PGF TNF 19583958 2162566 SB202190 successfully suppressed IL-6 , IL-8 , PGE2 , and [PGF2alpha] secretion in macrophage exposed AF cells in *response* to . Negative_regulation PGP CAPN8 10493948 646882 These results indicated that calpain involved Pgp turnover and that inhibition *induced* ubiquitinated [Pgp-accumulation] mainly at the cell surface membrane with a reduction in its own functions suggesting that the modulation of Pgp-turnover involves MDR-reversal by another approach . Negative_regulation PGP FOXO1 24268349 2892983 Down-regulation ( siRNA ) or hyperactivation ( nicotinamide ) of *led* to corresponding changes in [Pgp] . Negative_regulation PGP SPHK1 17316399 1699827 We also provide evidence that the overexpression of in the cerebral EC line RBE4 *leads* to the up-regulation of [P-gp] , both at the gene and protein levels , and that this modulation depends on the catalytic activity of SphK-1 . Negative_regulation PGP TNF 24130926 2714736 Furthermore , in both cell lines , or IFN-? *induced* significant decrease of [P-gp] activity for 24 hr treatment . Negative_regulation PHB EPHB2 22999878 2679147 Binding of rocaglamides to PHB prevents interaction between [PHB] and CRaf and , thereby , *inhibits* CRaf activation and subsequently signaling . Negative_regulation PHB MAP2K6 22999878 2679153 Binding of rocaglamides to PHB prevents interaction between [PHB] and CRaf and , thereby , *inhibits* CRaf activation and subsequently signaling . Negative_regulation PHEX TNF 20817730 2336402 Cooperative role of NF-{kappa}B and poly(ADP-ribose) polymerase 1 ( PARP-1 ) in the induced *inhibition* of [PHEX] expression in osteoblasts . Negative_regulation PHEX TNF 20817730 2336412 The aim of this study was to determine the molecular mechanism involved in *mediated* down-regulation of [Phex] gene transcription . Negative_regulation PHKA2 GPR115 10322114 612606 signaling and other stimuli of Pyk2 kinase activity significantly *block* the interaction between EWS and [Pyk2] . Negative_regulation PHKA2 GPR132 10322114 612595 signaling and other stimuli of Pyk2 kinase activity significantly *block* the interaction between EWS and [Pyk2] . Negative_regulation PHKA2 GPR87 10322114 612675 signaling and other stimuli of Pyk2 kinase activity significantly *block* the interaction between EWS and [Pyk2] . Negative_regulation PHKA2 ITGB2 11867690 918076 Most importantly , Ca(2) ( + ) mobilization did not *induce* activation of [PYK2] when the interaction was prevented with function blocking mAb , implying that the Ca(2) ( + ) -induced activation of PYK2 requires integrin engagement . Negative_regulation PI3 EPHB2 12594849 1061088 The association of [phosphoinositide 3-kinase (PI-3K)] to H4/ICOS was enhanced by H4/ICOS cross linking , and PI-3K inhibitors *inhibited* and JNK activation and IL-4/IL-10 secretion , but not p38 MAP kinase or ZAP-70 activation . Negative_regulation PI3 EPHB2 18953090 1982535 It was also shown that protective effects of DHEA , DHEAS and PGL against staurosporine induced LDH release were attenuated by extracellular signal regulated kinase ( ) -- mitogen activated protein kinase (MAPK) inhibitor -- PD 98059 ( 5 microM ) but not by [phosphatidylinositol-3-kinase (PI3-K)] *inhibitors* such as LY 294002 ( 1 microM ) or wortmannin ( 10 nM ) . Negative_regulation PI3 EPHB2 19538937 2109712 Preincubation of hPDLs with extracellular signal regulated kinase ( ) , c-Jun N-terminal kinase (JNK) , p38 kinase and [phosphatidylinositol 3-kinase (PI3K)] *inhibitors* PD98059 , SP600125 , SB203580 and LY294002 resulted in significant reduction in P. intermedia induced IL-6 , IL-8 and M-CSF expression . Negative_regulation PI3 FAS 9446703 483671 PI-3-K stimulation seems to be critical for CD95 receptor signalling since , first , inhibition of [PI-3-K] prevents *mediated* apoptosis and , second , CD95 receptor ligation fails to induce tyrosine phosphorylation or activation of PI-3-K in CD95-resistant glioma cells . Negative_regulation PI3 GNE 23867164 2825237 Identification of , a potent and selective [PI3Kd] *inhibitor* : navigating in vitro genotoxicity while improving potency and selectivity . Negative_regulation PI3 ITGB2 10931873 720212 Further evidence demonstrated that activation of [PI 3-kinase] by PDGF *induced* a decrease in the association of alpha-actinin with the subunit , and that PtdIns ( 3,4,5 ) -P ( 3 ) could disrupt this interaction in vitro . Negative_regulation PI3 MAP2K6 12842996 1141116 Combined treatment with [phosphatidylinositol 3-kinase (PI3K)] inhibitor , LY294002 , and mitogen activated protein kinase kinase ( ) *inhibitor* , PD98059 , dephosphorylated Bad and induced apoptosis in WtFLT3-32D cells stimulated with FL. Induction of nonphosphorylated Bad induced remarkable apoptosis . Negative_regulation PI3 MAP2K6 14985374 1214835 Cell migration and the localisation of Akt 1 , pAkt , and p27 were inhibited by [PI3] kinase , but not *inhibition* . Negative_regulation PI3 MAP2K6 19567590 2104444 We investigated the role of mitogen activated protein kinase kinase ( ) and [phosphatidylinositol 3-kinase (PI3K)] *inhibitors* as targeted therapies for basal-like breast cancer . Negative_regulation PI3 PECAM1 24030383 2857120 Activation of signaling *results* in its tyrosine phosphorylation , the recruitment and activation of tyrosine phosphatase SHP-2 , the subsequent binding of [phosphoinositol 3-kinase (PI3K)] , and diminished PI3K signaling . Negative_regulation PI3 TLR7 18287072 1872524 However , when coupled with Sema6D , a ligand for Plexin-A1 , limited *resulted* in PDC-TREM mediated DAP12 dependent phosphorylation of [phosphoinositide 3-kinase (PI3K)] and extracellular regulated kinase (Erk) 1/2 at 6-9 h , and IFN-alpha was produced . Negative_regulation PI3 TNF 10329978 613986 We observed that *impaired* insulin stimulation of IRS-1- and IRS-2 mediated [PI 3-kinase] activation by 54 and 55 % ( P < 0.05 ) , respectively . Negative_regulation PI3 TNF 12230886 988343 Induction of the SKALP promoter by *resulted* in increased expression levels of the secreted [SKALP-EGFP] fusion protein as assessed by direct readout of fluorescence and fluorescence polarization in 96-well cell culture plates . Negative_regulation PI3 TNF 12494458 1033458 FSS activated [PI3-kinase] signaling , induced phosphorylation of Akt , and *inhibited* induced activation of caspase-3 . Negative_regulation PIGR TCF12 9973374 596012 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Negative_regulation PIGR TCF15 9973374 596013 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Negative_regulation PIGR TCF19 9973374 596014 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Negative_regulation PIGR TCF20 9973374 596015 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Negative_regulation PIGR TCF21 9973374 596016 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Negative_regulation PIGR TCF23 9973374 596020 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Negative_regulation PIGR TCF24 9973374 596022 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Negative_regulation PIGR TCF25 9973374 596021 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Negative_regulation PIGR TCF3 9973374 596017 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Negative_regulation PIGR TCF4 9973374 596018 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Negative_regulation PIGR TCF7 9973374 596019 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Negative_regulation PIH TNNT2 21280551 2359873 The level of plasma thiobarbituric acid reactive substances ( TBARS ) , cTnI and levels significantly *increase* in [pregnancy induced hypertension] compare with other groups . Negative_regulation PIK3C3 IFI27 20823108 2336481 Western blot analysis revealed that honokiol : ( i ) inhibited the levels of cyclins D1 , D2 and E and associated cyclin dependent kinases (CDKs)2 , CDK4 and CDK6 , ( ii ) upregulated Cip/p21 and and ( iii ) *inhibited* the levels of [phosphatidylinositol 3-kinase] and the phosphorylation of Akt at Ser ( 473 ) in UVB induced skin tumors . Negative_regulation PIK3C3 IGFBP1 9325295 456810 We show that *inhibits* IGF-I induced survival and proliferation of BAF/3 cells , as well as IGF-I mediated activation of [phosphatidylinositol 3-kinase (PI 3-K)] . Negative_regulation PIK3C3 ITGAL 9341793 458797 Down-regulation of mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 *requires* [phosphatidylinositol-3-kinase] activity . Negative_regulation PIK3C3 MAP2K6 12527803 1048434 [Phosphatidylinositol (PI) 3-kinase] inhibition [ with wortmannin or 2- ( 4-morpholinyl ) -8-phenyl-1 ( 4H ) -benzopyran-4-one hydrochloride ] , infection with a dominant negative mutant of Akt , or signal regulated kinase 1/2 ( MEK/ERK1/2 ) *inhibition* ( with PD98059 or U0126 ) partially attenuated , whereas inhibition of both PI 3-kinase and MEK1/2 abolished H ( 2 ) O ( 2 ) -dependent NO* production . Negative_regulation PIK3C3 TNF 12360479 994924 The effect of PTEN or [phosphatidylinositol 3-kinase] *inhibition* and alpha on Cdx-2 messenger RNA and protein expression , Cdx-2 DNA binding activity , and the promoter activity of the Cdx-2 gene was analyzed in human colon cancer cell lines . Negative_regulation PIK3CA ARSA 23867870 2830028 Therefore , <5-ASA> reduces CUC induced reactive oxygen species in colonic progenitor cells and enhances PTEN activity , thus *attenuating* [PI3K/Akt] signaling . Negative_regulation PIK3CA EPHB2 11896055 944415 These experiments demonstrate that EGF and HGF mediated activation *result* in divergent effects on [Gab1/PI3K] signaling . Negative_regulation PIK3CA EPHB2 15205467 1281164 Thus , unlike galectin-1 , which prolongs Ras activation of and *inhibits* [PI3-K] , K-Ras-GTP/galectin-3 interactions promote , in addition to PI3-K and Raf-1 activation , a third inhibitory signal that attenuates active ERK . Negative_regulation PIK3CA EPHB2 16767222 1576566 The enhancing effects of HSP60 costimulation on Tregs involved innate signaling via TLR2 , *led* to activation of PKC , [PI3K] , and p38 , and were further enhanced by inhibition of . Negative_regulation PIK3CA EPHB2 20335475 2230903 Intracerebroventricular E ( 2 ) infusion also increased [PI3K] phosphorylation after 15 min , and this effect was *blocked* by intrahippocampal PI3K , but not , inhibition . Negative_regulation PIK3CA EPHB2 21209852 2359327 Furthermore , LPA increased [PI3K] activity , and the PI3K inhibitor LY294002 *inhibited* both LPA induced activation and cell migration . Negative_regulation PIK3CA FOXO1 22515357 2584475 Infection with oipA mutants reduced PI3K/Akt activation and inhibited FoxO1/3a phosphorylation , whereas infection with cag PAI mutants reduced [PI3K/Akt] activity but did not *inhibit* activation . Negative_regulation PIK3CA FUT4 20506505 2307919 Results show that overexpression of *increases* the phosphorylation of ERK1/2 , p38 MAPK , and [PI3K/Akt] . Negative_regulation PIK3CA GNE 20346656 2231149 Identification of , a potent and efficacious dual [PI3K/mTOR] *inhibitor* . Negative_regulation PIK3CA GNE 20346656 2231152 This discovery led to the identification of ( 8 ) , a potent and efficacious dual [PI3K/mTOR] *inhibitor* . Negative_regulation PIK3CA GNE 23814482 2808250 Interestingly , comparable antivascular effects were observed for both GDC-980 and ( a selective class I [PI3K] *inhibitor* ) . Negative_regulation PIK3CA MAP2K6 12554784 1057070 The mutant , which activates p38 , moderately *inhibited* IRS-1 and IRS-2 expressions and IRS-1 associated [PI3K] activity without exerting a significant effect on the IR . Negative_regulation PIK3CA MAP2K6 15287886 1278181 AMPA mediated neuroprotection is blocked by PP1 , an inhibitor of src family kinases , LY294002 , a [PI3-K] *inhibitor* , or U0126 , a MAPK kinase ( ) inhibitor . Negative_regulation PIK3CA MAP2K6 15336230 1291155 Amnion derived ( WISH ) cells were cultured , and the effect of insulin-like growth factor (IGF) , mitogen activated protein (MAP) kinase kinase and/or extracellular signal regulated kinase ( ERK ) kinase ( ) inhibitors ( U0126 ) , and [phosphatidylinositol (PI) 3-kinase] *inhibitors* ( wortmannin ) on the production of VEGF was examined . Negative_regulation PIK3CA MAP2K6 22552284 2618779 inhibition *leads* to [PI3K/AKT] activation by relieving a negative feedback on ERBB receptors . Negative_regulation PIK3CA MAP2K6 22552284 2618814 In this study , we describe a feedback mechanism in which inhibition *leads* to activation of [PI3K/AKT] signaling in EGFR and HER2-driven cancers . Negative_regulation PIK3CA MAP2K6 23259591 2711266 Alternative dosing of dual [PI3K] and *inhibition* in cancer therapy . Negative_regulation PIK3CA MAP2K6 9405284 480155 We have utilized a selective inhibitor of MAPK kinase ( ) , PD098059 , and two *inhibitors* of [PI3K] , wortmannin and LY294002 , to investigate the roles of these kinases in the regulation of neutrophil effector functions . Negative_regulation PIK3CA PECAM1 24030383 2857121 Activation of signaling *results* in its tyrosine phosphorylation , the recruitment and activation of tyrosine phosphatase SHP-2 , the subsequent binding of phosphoinositol 3-kinase (PI3K) , and diminished [PI3K] signaling . Negative_regulation PIK3CA PLAU 23615713 2804742 In addition , avß6 integrin *induced* the phosphorylation of p38 MAPK and [PI3 K/Akt] , contributing to the up-regulation of uPA , as treatment with the specific inhibitor for p38 mitogen activated protein kinases (MAPK) ( SB203580 ) or phosphatidylinositol 3-kinase (PI3 K)/Akt ( LY294002 ) strikingly abrogated expression . Negative_regulation PIK3CA RGS16 19509421 2115982 These results suggest that the loss of in some breast tumors *enhances* [PI3K] signaling elicited by growth factors and thereby promotes proliferation and TKI evasion downstream of HER activation . Negative_regulation PIK3CA STK39 24348050 2881002 [PI3K] inhibition *induced* the most significant effects on global signaling pathways in patient derived cell cultures , especially on members of the mitogen activated protein-kinase family , P70S6 , and cAMP response element binding protein expression and further prevented tumor cell proliferation . Negative_regulation PIK3CA TLR7 24251781 2903926 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , [PI3K/AkT] *inhibition* , IKK/JNK inhibition , mTORC1 inhibition , JAK/STAT inhibition , suppression , and ACE inhibition . Negative_regulation PIK3CA TNF 10202031 605917 , AG-490 ( Janus kinase inhibitor ) , and wortmannin ( [PI3-K] *inhibitor* ) inhibited activation of PDE3 and PDE4 by IL-4 . Negative_regulation PIK3CA TNF 11563846 863013 had no effect on insulin induced tyrosine-phosphorylation of IR or IRS-1 , but *inhibited* insulin stimulated [IRS-1/PI3K-association] by 84 % . Negative_regulation PIK3CA TNF 18441518 1900475 These results show that insulin down-regulates MAPK , [PI3K] and PKCs and *inhibits* a downstream effect of LPS , production , in rat AMs stimulated with LPS and suggest that the protective effect of insulin in sepsis could be through modulation of signal transduction pathways elicited by LPS in lung macrophages . Negative_regulation PIK3CA TNF 21054556 2349366 The effect of histamine on vitiliginous keratinocytes , in cultured cells treated with a [PI3K] inhibitor in the *presence* of , was also examined . Negative_regulation PIK3CA TNFSF10 22321426 2520718 To study the effects of combinative therapy of tumor necrosis factor related apoptosis inducing ligand ( ) and [PI3-K-Akt] *inhibitor* on the growth and apoptosis of nasopharyngeal carcinoma (NPC) cells and underlying mechanisms . Negative_regulation PIK3CA TNFSF10 23375756 2758821 Rat lung microvascular endothelial cells ( RLMECs ) grown on Transwell membranes ( Corning Life Sciences , Lowell , MA ) were treated with recombinant human ( 10 , 50 , and 100 ng/mL ) for 6 hours or TRAIL ( 100 ng/mL ) + LY294002 ( a [PI3K] *inhibitor* ; 20 µmol/L ) , Z-DEVD-FMK ( a caspase-3 inhibitor ; 10 µmol/L ) , or the inhibitors alone . Negative_regulation PIK3R1 ARSA 23867870 2830029 Therefore , <5-ASA> reduces CUC induced reactive oxygen species in colonic progenitor cells and enhances PTEN activity , thus *attenuating* [PI3K/Akt] signaling . Negative_regulation PIK3R1 EPHB2 11896055 944416 These experiments demonstrate that EGF and HGF mediated activation *result* in divergent effects on [Gab1/PI3K] signaling . Negative_regulation PIK3R1 EPHB2 15205467 1281168 Thus , unlike galectin-1 , which prolongs Ras activation of and *inhibits* [PI3-K] , K-Ras-GTP/galectin-3 interactions promote , in addition to PI3-K and Raf-1 activation , a third inhibitory signal that attenuates active ERK . Negative_regulation PIK3R1 EPHB2 16767222 1576567 The enhancing effects of HSP60 costimulation on Tregs involved innate signaling via TLR2 , *led* to activation of PKC , [PI3K] , and p38 , and were further enhanced by inhibition of . Negative_regulation PIK3R1 EPHB2 20335475 2230904 Intracerebroventricular E ( 2 ) infusion also increased [PI3K] phosphorylation after 15 min , and this effect was *blocked* by intrahippocampal PI3K , but not , inhibition . Negative_regulation PIK3R1 EPHB2 21209852 2359330 Furthermore , LPA increased [PI3K] activity , and the PI3K inhibitor LY294002 *inhibited* both LPA induced activation and cell migration . Negative_regulation PIK3R1 FOXO1 22515357 2584477 Infection with oipA mutants reduced PI3K/Akt activation and inhibited FoxO1/3a phosphorylation , whereas infection with cag PAI mutants reduced [PI3K/Akt] activity but did not *inhibit* activation . Negative_regulation PIK3R1 FUT4 20506505 2307920 Results show that overexpression of *increases* the phosphorylation of ERK1/2 , p38 MAPK , and [PI3K/Akt] . Negative_regulation PIK3R1 GNE 20346656 2231150 Identification of , a potent and efficacious dual [PI3K/mTOR] *inhibitor* . Negative_regulation PIK3R1 GNE 20346656 2231153 This discovery led to the identification of ( 8 ) , a potent and efficacious dual [PI3K/mTOR] *inhibitor* . Negative_regulation PIK3R1 GNE 23814482 2808251 Interestingly , comparable antivascular effects were observed for both GDC-980 and ( a selective class I [PI3K] *inhibitor* ) . Negative_regulation PIK3R1 MAP2K6 12554784 1057071 The mutant , which activates p38 , moderately *inhibited* IRS-1 and IRS-2 expressions and IRS-1 associated [PI3K] activity without exerting a significant effect on the IR . Negative_regulation PIK3R1 MAP2K6 15287886 1278201 AMPA mediated neuroprotection is blocked by PP1 , an inhibitor of src family kinases , LY294002 , a [PI3-K] *inhibitor* , or U0126 , a MAPK kinase ( ) inhibitor . Negative_regulation PIK3R1 MAP2K6 15336230 1291162 Amnion derived ( WISH ) cells were cultured , and the effect of insulin-like growth factor (IGF) , mitogen activated protein (MAP) kinase kinase and/or extracellular signal regulated kinase ( ERK ) kinase ( ) inhibitors ( U0126 ) , and [phosphatidylinositol (PI) 3-kinase] *inhibitors* ( wortmannin ) on the production of VEGF was examined . Negative_regulation PIK3R1 MAP2K6 22552284 2618786 inhibition *leads* to [PI3K/AKT] activation by relieving a negative feedback on ERBB receptors . Negative_regulation PIK3R1 MAP2K6 22552284 2618821 In this study , we describe a feedback mechanism in which inhibition *leads* to activation of [PI3K/AKT] signaling in EGFR and HER2-driven cancers . Negative_regulation PIK3R1 MAP2K6 23259591 2711273 Alternative dosing of dual [PI3K] and *inhibition* in cancer therapy . Negative_regulation PIK3R1 MAP2K6 9405284 480162 We have utilized a selective inhibitor of MAPK kinase ( ) , PD098059 , and two *inhibitors* of [PI3K] , wortmannin and LY294002 , to investigate the roles of these kinases in the regulation of neutrophil effector functions . Negative_regulation PIK3R1 PECAM1 24030383 2857122 Activation of signaling *results* in its tyrosine phosphorylation , the recruitment and activation of tyrosine phosphatase SHP-2 , the subsequent binding of phosphoinositol 3-kinase (PI3K) , and diminished [PI3K] signaling . Negative_regulation PIK3R1 PLAU 23615713 2804743 In addition , avß6 integrin *induced* the phosphorylation of p38 MAPK and [PI3 K/Akt] , contributing to the up-regulation of uPA , as treatment with the specific inhibitor for p38 mitogen activated protein kinases (MAPK) ( SB203580 ) or phosphatidylinositol 3-kinase (PI3 K)/Akt ( LY294002 ) strikingly abrogated expression . Negative_regulation PIK3R1 RGS16 19509421 2115983 These results suggest that the loss of in some breast tumors *enhances* [PI3K] signaling elicited by growth factors and thereby promotes proliferation and TKI evasion downstream of HER activation . Negative_regulation PIK3R1 STK39 24348050 2881017 [PI3K] inhibition *induced* the most significant effects on global signaling pathways in patient derived cell cultures , especially on members of the mitogen activated protein-kinase family , P70S6 , and cAMP response element binding protein expression and further prevented tumor cell proliferation . Negative_regulation PIK3R1 TLR7 24251781 2903953 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , [PI3K/AkT] *inhibition* , IKK/JNK inhibition , mTORC1 inhibition , JAK/STAT inhibition , suppression , and ACE inhibition . Negative_regulation PIK3R1 TNF 10202031 605918 , AG-490 ( Janus kinase inhibitor ) , and wortmannin ( [PI3-K] *inhibitor* ) inhibited activation of PDE3 and PDE4 by IL-4 . Negative_regulation PIK3R1 TNF 11563846 863014 had no effect on insulin induced tyrosine-phosphorylation of IR or IRS-1 , but *inhibited* insulin stimulated [IRS-1/PI3K-association] by 84 % . Negative_regulation PIK3R1 TNF 18441518 1900476 These results show that insulin down-regulates MAPK , [PI3K] and PKCs and *inhibits* a downstream effect of LPS , production , in rat AMs stimulated with LPS and suggest that the protective effect of insulin in sepsis could be through modulation of signal transduction pathways elicited by LPS in lung macrophages . Negative_regulation PIK3R1 TNF 21054556 2349367 The effect of histamine on vitiliginous keratinocytes , in cultured cells treated with a [PI3K] inhibitor in the *presence* of , was also examined . Negative_regulation PIK3R1 TNFSF10 22321426 2520719 To study the effects of combinative therapy of tumor necrosis factor related apoptosis inducing ligand ( ) and [PI3-K-Akt] *inhibitor* on the growth and apoptosis of nasopharyngeal carcinoma (NPC) cells and underlying mechanisms . Negative_regulation PIK3R1 TNFSF10 23375756 2758822 Rat lung microvascular endothelial cells ( RLMECs ) grown on Transwell membranes ( Corning Life Sciences , Lowell , MA ) were treated with recombinant human ( 10 , 50 , and 100 ng/mL ) for 6 hours or TRAIL ( 100 ng/mL ) + LY294002 ( a [PI3K] *inhibitor* ; 20 µmol/L ) , Z-DEVD-FMK ( a caspase-3 inhibitor ; 10 µmol/L ) , or the inhibitors alone . Negative_regulation PIK3R4 IFI27 20823108 2336484 Western blot analysis revealed that honokiol : ( i ) inhibited the levels of cyclins D1 , D2 and E and associated cyclin dependent kinases (CDKs)2 , CDK4 and CDK6 , ( ii ) upregulated Cip/p21 and and ( iii ) *inhibited* the levels of [phosphatidylinositol 3-kinase] and the phosphorylation of Akt at Ser ( 473 ) in UVB induced skin tumors . Negative_regulation PIK3R4 IGFBP1 9325295 456811 We show that *inhibits* IGF-I induced survival and proliferation of BAF/3 cells , as well as IGF-I mediated activation of [phosphatidylinositol 3-kinase (PI 3-K)] . Negative_regulation PIK3R4 ITGAL 9341793 458798 Down-regulation of mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 *requires* [phosphatidylinositol-3-kinase] activity . Negative_regulation PIK3R4 MAP2K6 12527803 1048442 [Phosphatidylinositol (PI) 3-kinase] inhibition [ with wortmannin or 2- ( 4-morpholinyl ) -8-phenyl-1 ( 4H ) -benzopyran-4-one hydrochloride ] , infection with a dominant negative mutant of Akt , or signal regulated kinase 1/2 ( MEK/ERK1/2 ) *inhibition* ( with PD98059 or U0126 ) partially attenuated , whereas inhibition of both PI 3-kinase and MEK1/2 abolished H ( 2 ) O ( 2 ) -dependent NO* production . Negative_regulation PIK3R4 TNF 12360479 994925 The effect of PTEN or [phosphatidylinositol 3-kinase] *inhibition* and alpha on Cdx-2 messenger RNA and protein expression , Cdx-2 DNA binding activity , and the promoter activity of the Cdx-2 gene was analyzed in human colon cancer cell lines . Negative_regulation PIP CST6 25215010 2523388 The levels of PaO2/FiO2 and *increased* after treatment in the two groups , but they were higher in the RM group than in the non-RM group ( P < 0.05 ) . The [PIP] and Pplat decreased after treatment in the two groups , but they were lower in the RM group than in the non-RM group ( P < 0.05 ) . The EVLWI in the two groups showed downward trend after treatment ( P < 0.05 ) , and the differences were signifcant at all time points ( P < 0.01 ) ; the EVLWI in the RM group was lower than that in the non-RM group at 12 , 24 , 48 and 72 hours ( P < 0.05 or P < 0.01 ) . Compared with pre-RM , hemodynamics changes during RM were significantly different ( P < 0.01 ) ; compared with pre-RM , the changes were not significantly different at 120 seconds after the end of RM ( P > 0.05 ) . Negative_regulation PIP TNF 8170501 255193 To investigate one of the possible mechanisms of the *induced* decrease of [PIP2] formation , the effect of TNF alpha pretreatment on glycerol-3-phosphate dehydrogenase (GDH) , a key enzyme of lipogenesis , was studied : Exposure of the rat cardiomyocytes for 72 h to TNF alpha induced a concentration dependent decrease in GDH activity by maximally 55 % . Negative_regulation PKN1 CCND1 21719533 2471295 We have found that adapter protein Nck sequesters [PAK1] in the cytoplasm and that coexpression of both PAK1 and Nck *inhibits* the amplifying effect of PRL induced PAK1 on promoter activity ( 95 % inhibition ) . Negative_regulation PLA2G1B ALOX5 7562506 324312 However , SK & F 45905 inhibited 85-kDa [PLA2] activity ( IC50 = 3 microM ) , and both compounds *inhibited* <5-lipoxygenase> activity ( IC50 values of 2-4 microM ) . Negative_regulation PLA2G1B FAS 8846779 338010 cross linking *resulted* also in ERK-2 activation and in [phospholipase A2 (PLA2)] induction , independently of the PC-PLC/aSMase pathway . Negative_regulation PLA2G1B IFI27 19497413 2091844 Although both compounds are weakly but equally effective inhibitors of iNOS protein expression and activity , only Se-PBIT significantly enhanced the levels of p53 , p38 , and p21 protein expression , *reduced* levels of [phospholipase A2 (PLA2)] but had no effect on cyclooxygenase-2 (COX-2) protein levels ; Negative_regulation PLA2G1B IL1B 11930237 927346 The experiments were carried out to explore the interactions between gene expression , protein level and [phospholipase A(2)] PLA(2) *inhibition* after intestinal ischemia/reperfusion injury . Negative_regulation PLA2G1B IL1B 1568479 186949 The glucocorticoid dexamethasone only partially suppressed the and forskolin induced elevation of PLA2 mRNA , but totally *inhibited* [PLA2] synthesis and secretion . Negative_regulation PLA2G1B IL1B 8431204 212785 Stimulation of synovial cells with recombinant *induced* a decrease in phosphatidylcholine ( PC ) , phosphatidylinositol ( PI ) , and phosphatidylethanolamine (PE) , and a marked increase in cell associated [PLA2] activity as compared with controls . Negative_regulation PLA2G1B IL1B 9124287 419507 Additionally , caused an increase in arachidonic acid release in 20 min. Pretreatment with E-6- ( bromomethylene ) tetrahydro-3- ( 1-naphthalenyl ) -2H-pyran-2-one , a selective Ca2+ independent PLA2 inhibitor , *blocked* IL-1beta induced increases in both [PLA2] activity and arachidonic acid release . Negative_regulation PLA2G1B TNF 1643102 194848 Glucocorticoids only moderately reduced [PLA2] activity in control cells , but completely *inhibited* the induced increase in the activity of the high-molecular-weight cytosolic PLA2 . Negative_regulation PLA2G1B TNF 2033082 159618 H-7 , a protein kinase C inhibitor , inhibited the LPS induced [PLA2-II] expression , but did not *inhibit* the induced one . Negative_regulation PLA2G1B TNF 22031851 2547573 Studies in mesangial cells and macrophages were carried out to establish that the in vivo increase in PLA(2) and COX were mediated by and IL-1ß and that curcumin , by antagonizing the cytokines , could significantly *reduce* both [PLA(2)] and COX . Negative_regulation PLA2G1B TNF 8040024 266653 We propose therefore , that ketoconazole may reduce acute radiation sequelae such as mucositis and esophagitis through a reduction in induction or *inhibition* of [phospholipase A2] in addition to its antifungal activity . Negative_regulation PLA2G2A PROC 19683795 2208951 Thrombin and *inhibit* the expression of secretory [group IIA phospholipase A(2)] in the TNF-alpha activated endothelial cells by EPCR and PAR-1 dependent mechanisms . Negative_regulation PLA2G4A ALOX5 18665843 1979416 In vitro responses of asthma ( N=26 ) and healthy ( N=11 ) subject PBMC samples to allergen stimulation in the presence and absence of [cPLA(2)alpha] inhibition or <5-lipoxygenase> *inhibition* were compared at the gene expression level using oligonucleotide arrays and at the protein level using ELISA . Negative_regulation PLA2G4A ALOX5 9654399 516127 Terfenadine inhibited the synthesis of LTC4 to 67.2 % at a concentration of 5 microg/ml. LT synthesis was directly suppressed by inhibition of <5-lipoxygenase (5-LO)> through calcium ion independent mechanisms , and was also possibly *suppressed* by inhibition of [cytosolic phospholipase A2] and 5-LO by blocking the influx of intracellular calcium ion that was initiated by IgE related stimulation . Negative_regulation PLA2G4A ARSA 12832097 1105568 Our results indicate that the *induced* downregulation of [cytosolic phospholipase A2] mRNA expression might be a novel mechanism for ASA mediated growth inhibition and apoptosis in colon cancer cells . Negative_regulation PLA2G4A EPHB2 16806823 1631837 Galpha13 mediates *activation* of the [cytosolic phospholipase A2alpha] through fine regulation of phosphorylation . Negative_regulation PLA2G4A IL1B 10843735 700292 these cytokines apparently suppressed IL-1beta stimulated COX-2 expression and only weakly suppressed [cPLA(2)expression] in *response* to . Negative_regulation PLA2G4A IL1B 15205451 1295585 significantly increased the phosphorylation of extracellular signal regulated kinase 1 ( ERK1 ) /ERK2 MAPKs and cPLA(2) and IL-1beta induced [cPLA(2)] phosphorylation was *blocked* by PD98059 . Negative_regulation PLA2G4A TNF 24349530 2881292 Decreased transcription of the PLA2G4A and COX2 genes in response to cPLA2a enzyme inhibition further suggest a self reinforcing effect of [cPLA2a] inhibition in *response* to . Negative_regulation PLA2G4A TNF 9060638 417771 We now report that induces translocation of cPLA2 from the cytosol to membranes in Ad-infected human A549 cells and that E3-10.4K/14.5K but not E3-14.7K or E1B-19K is required to *inhibit* TNF induced translocation of [cPLA2] . Negative_regulation PLA2G4A TNF 9759860 536557 The trifluoromethyl ketone analogue of eicosapentaenoic acid ( EPACOCF3 ) also suppressed induced NF-kappaB activation and *inhibited* in vitro [cPLA2] enzyme activity with a similar potency as AACOCF3 . Negative_regulation PLA2G6 IL1B 10642306 660794 We tested whether iPLA(2) metabolites are involved in the regulation by of iNOS with the use of bromoenol lactone ( BEL ) , a specific and irreversible *inhibitor* of [iPLA(2)] . Negative_regulation PLAGL1 JUN 16061485 1460153 Luciferase reporter analysis and mutagenesis of the Lot1 promoter region indicated a crucial *role* of the binding site ( located at -268 bp ) in cAMP induced [Lot1] transcription . Negative_regulation PLAT ACE 10906625 715340 By blocking the degradation of bradykinin , inhibitors potentiate the ability of bradykinin to reduce blood pressure and *stimulate* the release of [tissue-type plasminogen activator] from the vasculature , an effect not seen with AT1 receptor blockers . Negative_regulation PLAT ACE 12437489 1016165 This is because the inhibitors , but not the AT-1 receptor antagonists , *increase* the levels of substance P , bradykinin and [tissue plasminogen activator] . Negative_regulation PLAT ACE 12566370 1054577 inhibition *increases* human vascular [tissue-type plasminogen activator] release through endogenous bradykinin . Negative_regulation PLAT ACE 16166566 1476020 inhibition *increases* basal vascular [tissue plasminogen activator] release in women but not in men . Negative_regulation PLAT ACE 16166566 1476021 inhibition ( ACEI ) *increases* vascular [tissue plasminogen activator (t-PA)] release through endogenous bradykinin ( BK ) . Negative_regulation PLAT ACLY 16320350 1490896 To test the hypotheses that some plasmin-reactive may bind to tissue plasminogen activator (tPA) and that some of the tPA-reactive aCL may *inhibit* [tPA] activity . Negative_regulation PLAT ADCYAP1 11870092 918408 The use of cycloheximide , a protein synthesis inhibitor , suggested that *requires* an intermediary protein to decrease uPA-mRNA , but not to induce [tPA-mRNA] . Negative_regulation PLAT ANXA2 15257287 1274348 siRNA mediated downregulation of and disruption of the complex by microinjection of peptide competitors *result* in a marked reduction in vWF but not [tPA] secretion , without affecting the appearance of WPbs . Negative_regulation PLAT ANXA2 9545344 498582 [Tissue plasminogen activator] binding to immobilized annexin II was *inhibited* by intact fluid phase but not by its `` core '' fragment ( residues 25-339 ) . Negative_regulation PLAT APOB 11788661 901545 The results of the present study suggest that and VLDL from patients with DM *reduce* the generation of [tPA] and increase PAI-1 production through the activation of the PAI-1 promoter in vascular EC . Negative_regulation PLAT APOB 12841345 1108291 LDL and [ Lp(a) ] , another lipoprotein risk factor for CHD , *reduced* the generation of [tPA] from EC . Negative_regulation PLAT APOB 1966796 149809 Absence of inhibition by *inhibition* of [tPA] induced thrombolysis in a patient 's plasma milieu . Negative_regulation PLAT APOB 9672075 520077 Glycated did not significantly reduce the levels of tPA mRNA but *attenuated* de novo synthesis of [tPA] in ECs . Negative_regulation PLAT ARG1 2971531 97092 *inhibited* plasmin and [tPA] but had no effect on urokinase . Negative_regulation PLAT ARG2 2971531 97093 *inhibited* plasmin and [tPA] but had no effect on urokinase . Negative_regulation PLAT ASIP 8286412 247489 This evidence indicates strongly that the N-terminal of STI prevents its binding to and *inhibiting* [tPA] . Negative_regulation PLAT BANF1 1462839 206717 C and incompletely *inhibited* the fibrinolytic activity of [tPA] by the active PAI . Negative_regulation PLAT CA2 9351387 461127 In this study , we investigated the *role* of and G proteins in thrombin induced acute release ( regulated secretion ) of [tissue-type plasminogen activator (TPA)] and von Willebrand factor (vWF) , using a previously described system of primary human umbilical vein endothelial cells ( HUVECs ) . Negative_regulation PLAT CGA 16514196 1530778 The results suggest that surge *induced* regulation of tissue inhibitor of metalloproteinase-4 and [tissue plasminogen activator] may be prostanoid dependent , and support a potential role for increased tissue plasminogen activator expression and decreased tissue inhibitor of metalloproteinase-4 expression in the mechanism of ovulation . Negative_regulation PLAT CGB8 16514196 1530777 The results suggest that surge *induced* regulation of tissue inhibitor of metalloproteinase-4 and [tissue plasminogen activator] may be prostanoid dependent , and support a potential role for increased tissue plasminogen activator expression and decreased tissue inhibitor of metalloproteinase-4 expression in the mechanism of ovulation . Negative_regulation PLAT CPB1 18706698 1974327 The activated removes the newly exposed carboxyl terminal lysines in the partially digested fibrin clot , *diminishes* [tissue plasminogen activator] and plasminogen binding , and protects the clot from premature lysis . Negative_regulation PLAT CPB1 19025114 1992349 The activated removes the newly exposed carboxyl terminal lysines in the partially digested fibrin clot , *diminishes* [tissue plasminogen activator] and plasminogen binding , and protects the clot from premature lysis . Negative_regulation PLAT CPB2 14697941 1180480 The aim of the study was to evaluate associations between some fibrinolytic factors : antigens of [tissue-type plasminogen activator (t-PA)] , plasminogen activator inhibitor ( PAI-1 ) , and thrombin-activatable fibrinolysis *inhibitor* ( ) , and IMT in a population of renal transplant recipients . Negative_regulation PLAT CPB2 16167916 1457036 Markers of fibrinolysis , thrombin-activatable fibrinolysis *inhibitor* ( ) , [tissue-type plasminogen activator] ( tPA ) , and plasminogen activator inhibitor-1 ( PAI-1 ) levels were studied for the evaluation of short-term effects of raloxifene administration in postmenopausal women . Negative_regulation PLAT CPB2 17764874 1801873 Blood was taken before induction , and 5 minutes , 24 hours , and 48 hours after aortic cross-clamp release and assayed for plasma TF , TFPI , [tissue plasminogen activator (t-PA)] , plasminogen activator inhibitor (PAI) , and thrombin-activatable fibrinolysis *inhibitor* ( ) activities . Negative_regulation PLAT CPB2 18183354 2040901 Plasma plasminogen activator inhibitor ( PAI-1 ) antigen ( Ag ) , [tissue plasminogen activator (t-PA)] Ag and thrombin-activatable fibrinolysis *inhibitor* ( ) activity levels were measured at baseline and at 4 weeks after the first dose of GnRH agonist , Goserelin Acetate ( Zoladex , subcutaneous administration , 10.8 mg ) . Negative_regulation PLAT CPB2 18706698 1974328 The activated removes the newly exposed carboxyl terminal lysines in the partially digested fibrin clot , *diminishes* [tissue plasminogen activator] and plasminogen binding , and protects the clot from premature lysis . Negative_regulation PLAT CPB2 19025114 1992350 The activated removes the newly exposed carboxyl terminal lysines in the partially digested fibrin clot , *diminishes* [tissue plasminogen activator] and plasminogen binding , and protects the clot from premature lysis . Negative_regulation PLAT CPB2 19436948 2240696 Serum VEGF and plasma von Willebrand factor , soluble thrombomodulin , plasminogen activator inhibitor 1 , thrombin-activatable fibrinolysis *inhibitor* ( ) and [tissue plasminogen activator (t-PA)] were measured using enzyme linked immunosorbent assay in all subjects . Negative_regulation PLAT CPB2 19943771 2447292 Plasma [tissue-type plasminogen activator (tPA)] , thrombin-activatable fibrinolysis *inhibitor* ( ) , plasminogen activator inhibitor-1 ( PAI-1 ) , thrombin-antithrombin complex (TAT) and thrombomodulin (TM) were measured at admission for all groups . Negative_regulation PLAT CPB2 20039901 2356942 To our knowledge , [tissue plasminogen activator] inhibitor-1 ( PAI-1 ) , plasma tissue factor pathway inhibitor (TFPI) and thrombin-activatable fibrinolysis *inhibitor* ( ) levels in these patients have not been investigated . Negative_regulation PLAT CPB2 20699259 2479914 Euglobulin lysis time ( ELT ) , plasma levels of D-dimer , [tissue-type plasminogen activator (t-PA)] , plasminogen activator inhibitor 1 ( PAI-1 ) , and thrombin activatable fibrinolysis *inhibitor* ( ) were determined before treatment , 2 weeks , 1 month , and 3 months after the initiation of the treatment . Negative_regulation PLAT CPB2 21519232 2463775 The aim of the study was to investigate the relationship among plasminogen activator inhibitor 1 ( PAI-1 ) , thrombin-activable fibrinolysis *inhibitor* ( ) , [tissue plasminogen activator (t-PA)] , prothrombin fragments 1+2 (F1+2) , glycemic control , hypertension , sex and body mass index ( BMI ) in DM2 patients with normoalbuminuria and microalbuminuria . Negative_regulation PLAT CPB2 22985614 2674319 We determined the profile of coagulation/fibrinolytic and vascular endothelial cell function parameters including plasminogen activator inhibitor (PAI) and thrombin-activatable fibrinolysis *inhibitor* ( ) , tissue factor pathway inhibitor (TFPI) , thrombomodulin (TM) , and [tissue plasminogen activator (tPA)] levels in children with hypothyroidism . Negative_regulation PLAT CPB2 23726093 2823574 The aim of this study was to examine the pathophysiological relationships between coagulation , fibrinolysis and fibrinolytic shutdown by evaluating the levels of coagulofibrinolytic markers , including soluble fibrin , thrombin-activatable fibrinolysis *inhibitor* ( ) , [tissue plasminogen activator-plasminogen] activator inhibitor-1 complex ( tPAIC ) , plasmin-alpha2 plasmin inhibitor complex ( PPIC ) , neutrophil elastase and fibrin degradation product by neutrophil elastase ( EXDP ) . Negative_regulation PLAT CPB2 25210670 2958238 Physical parameters were documented and blood specimen was tested at pre and post-intervention for fibrinogen , [tissue plasminogen activator (t-PA)] , plasminogen activator inhibitor-1 ( PAI-1 ) , and thrombin activatable fibrinolysis *inhibitor* ( ) . Negative_regulation PLAT CREB1 11179965 784816 Ectopic expression of the *inhibits* phorbol ester mediated induction of [tissue-type plasminogen activator] gene expression . Negative_regulation PLAT CREB3 11179965 784817 Ectopic expression of the *inhibits* phorbol ester mediated induction of [tissue-type plasminogen activator] gene expression . Negative_regulation PLAT CREB5 11179965 784815 Ectopic expression of the *inhibits* phorbol ester mediated induction of [tissue-type plasminogen activator] gene expression . Negative_regulation PLAT CSRP1 16123325 1461104 *inhibits* [tPA] activity via generation of proinflammatory cytokines ( IL-1beta and TNFalpha ) . Negative_regulation PLAT DNMT1 24117907 2902791 Ethanol also increased [tPA] protein expression and release , and *inhibited* activity with a corresponding decrease in DNA methylation levels of the tPA promoter . Negative_regulation PLAT F12 1737024 181841 An amount of PIXI which inhibited by 50 % factor XIa cleavage of the chromogenic substrate S2366 ( Pyr-Glu-Pro-Arg-pNA-2H2O ) only slightly inhibited ( 5-9 % ) , plasma kallikrein , plasmin , and activated protein C and did not *inhibit* factor Xa , thrombin , [tPA] , or trypsin , suggesting specificity for factor XIa . Negative_regulation PLAT F8 1653670 164677 3. Venous blood samples were taken before , during and after the procedure for assay of plasma vasopressin , adrenaline and noradrenaline concentrations , coagulant activity , von Willebrand factor antigen level , euglobulin clot lysis time , tissue-type plasminogen activator activity and [tissue-type plasminogen activator] *inhibition* . Negative_regulation PLAT F8 3947483 57885 In female patients the concentrations of , von Willebrand factor , the fast *inhibitor* of [tissue plasminogen activator] , alpha 2-antiplasmin , and C1 inhibitor were significantly increased . Negative_regulation PLAT FGB 1563856 184885 hemostatic profile : , fibrinopeptide A , antithrombin III , factor VIII antigen , factor VIII coagulant , protein C , plasminogen , alpha 2-antiplasmin , euglobulin clot lysis time and tissue plasminogen activator before and after venous occlusion , [tissue plasminogen activator] *inhibitor* , platelet factor 4 , beta-thromboglobulin . Negative_regulation PLAT FGF2 16806868 1599835 In contrast , *inhibited* [tPA] secretion and SERPINE2 secretion and expression . Negative_regulation PLAT GRAP2 15625301 1362089 In a mouse model of focal cerebral ischemia , [tPA] *induces* eNOS inhibition , ERK-2 activation , and inhibition , possibly as part of a more complex signaling response exacerbating brain injury . Negative_regulation PLAT ICAM1 23870459 2825365 Participants at risk of diabetes were more insulin-resistant according to different indicators , and had significantly higher levels of soluble ( sICAM-1 ) , [tissue plasminogen activator (tPA)] , *inhibitor* of plasminogen activator-1 (PAi-1) , high sensitivity C-reactive protein and free fatty acids , signaling the presence of multiple proatherogenic alterations despite the absence of overt diabetes . Negative_regulation PLAT IL1A 11594749 870035 In contrast to the induction of mRNA , [tPA] activity and protein levels in the harvested medium were dramatically *diminished* by . Negative_regulation PLAT IL1B 7552526 323255 *suppressed* production of uPA and [tPA] in both types of SMCs . Negative_regulation PLAT JUN 18982462 2006570 We have analyzed a possible *role* of mitogen activated protein kinase (MAPK) and in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Negative_regulation PLAT KLKB1 3930349 52308 Factor VIII activity and related antigen , fibrinogen , fibrinopeptide A , antithrombin III , plasminogen , [tissue plasminogen activator (t-PA)] , fast inhibitor of t-PA , alpha 2-antiplasmin , urokinase inhibitors , fragment B beta 15-42 and *inhibition* were analyzed . Negative_regulation PLAT KRT14 19916923 2166630 Angiostatin K1-3 ( up to 2 microM ) had no effect , while 2 microM angiostatins and K1-4 .5 *inhibited* the fibrin stimulated Glu-plasminogen activation by [tPA] by 50 and 100 % , respectively . Negative_regulation PLAT LEP 20051227 2200928 We tested the hypothesis that induces PAI-1 and *inhibits* [tPA] expression using human coronary artery endothelial cells ( HCAEC ) in culture as these cells play an important role in atherosclerosis . Negative_regulation PLAT LPA 12208147 983753 Binding of plasminogen to annexin II is inhibited by and binding of [tissue plasminogen activator] to annexin II is *blocked* by homocysteine . Negative_regulation PLAT LPA 12841345 1108292 LDL and [ Lp(a) ] , another lipoprotein risk factor for CHD , *reduced* the generation of [tPA] from EC . Negative_regulation PLAT LPA 1966796 149810 Absence of inhibition by *inhibition* of [tPA] induced thrombolysis in a patient 's plasma milieu . Negative_regulation PLAT LPA 8857956 388372 In experiments using anti-actin antibodies added in excess to cultured ECs , binding of plasminogen was inhibited by 45 % , [tPA] binding was *inhibited* by 46 % and binding was reduced by 56 % , confirming actin as a binding site for these various ligands whilst attesting to the presence of other EC receptors for these proteins . Negative_regulation PLAT LRP1 16489109 1589222 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of [tPA] and *inhibit* the tPA mediated interaction between and alphavbeta3 . Negative_regulation PLAT LRP10 16489109 1589219 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of [tPA] and *inhibit* the tPA mediated interaction between and alphavbeta3 . Negative_regulation PLAT LRP11 16489109 1589220 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of [tPA] and *inhibit* the tPA mediated interaction between and alphavbeta3 . Negative_regulation PLAT LRP12 16489109 1589221 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of [tPA] and *inhibit* the tPA mediated interaction between and alphavbeta3 . Negative_regulation PLAT LRP2 16489109 1589223 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of [tPA] and *inhibit* the tPA mediated interaction between and alphavbeta3 . Negative_regulation PLAT LRP3 16489109 1589224 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of [tPA] and *inhibit* the tPA mediated interaction between and alphavbeta3 . Negative_regulation PLAT LRP4 16489109 1589225 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of [tPA] and *inhibit* the tPA mediated interaction between and alphavbeta3 . Negative_regulation PLAT LRP5 16489109 1589226 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of [tPA] and *inhibit* the tPA mediated interaction between and alphavbeta3 . Negative_regulation PLAT LRP6 16489109 1589227 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of [tPA] and *inhibit* the tPA mediated interaction between and alphavbeta3 . Negative_regulation PLAT LRP8 16489109 1589228 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of [tPA] and *inhibit* the tPA mediated interaction between and alphavbeta3 . Negative_regulation PLAT MAP6 18815270 1970175 Treatment of rat hippocampal slices with the VGF derived peptide TLQP62 resulted in transient potentiation through a mechanism that was selectively blocked by the BDNF scavenger TrkB-Fc , the Trk tyrosine kinase inhibitor K252a ( 100 nm ) , and tPA , an *inhibitor* of [tissue plasminogen activator (tPA)] , an enzyme involved in pro-BDNF cleavage to BDNF , but was not blocked by the NMDA receptor antagonist APV , anti-p75 ( NTR ) function blocking antiserum , or previous tetanic stimulation . Negative_regulation PLAT MAPK1 16879221 1593900 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Negative_regulation PLAT MAPK1 18982462 2006571 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Negative_regulation PLAT MAPK10 16879221 1593901 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Negative_regulation PLAT MAPK10 18982462 2006572 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Negative_regulation PLAT MAPK11 16879221 1593902 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Negative_regulation PLAT MAPK11 18982462 2006573 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Negative_regulation PLAT MAPK12 16879221 1593903 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Negative_regulation PLAT MAPK12 18982462 2006574 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Negative_regulation PLAT MAPK13 16879221 1593904 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Negative_regulation PLAT MAPK13 18982462 2006575 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Negative_regulation PLAT MAPK14 16879221 1593905 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Negative_regulation PLAT MAPK14 18982462 2006576 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Negative_regulation PLAT MAPK15 16879221 1593899 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Negative_regulation PLAT MAPK15 18982462 2006569 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Negative_regulation PLAT MAPK3 16879221 1593906 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Negative_regulation PLAT MAPK3 18982462 2006577 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Negative_regulation PLAT MAPK4 16879221 1593907 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Negative_regulation PLAT MAPK4 18982462 2006578 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Negative_regulation PLAT MAPK6 16879221 1593908 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Negative_regulation PLAT MAPK6 18982462 2006579 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Negative_regulation PLAT MAPK7 16879221 1593909 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Negative_regulation PLAT MAPK7 18982462 2006580 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Negative_regulation PLAT MAPK8 16879221 1593910 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Negative_regulation PLAT MAPK8 18982462 2006581 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Negative_regulation PLAT MAPK9 16879221 1593911 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Negative_regulation PLAT MAPK9 18982462 2006582 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Negative_regulation PLAT NCAM1 12387826 1000229 Soluble transiently *inhibited* [tPA] mRNA expression levels in a MAPK dependent manner , while stimulation of MAPK alone induced tPA reduction in cells . Negative_regulation PLAT NCAM2 12387826 1000230 Soluble transiently *inhibited* [tPA] mRNA expression levels in a MAPK dependent manner , while stimulation of MAPK alone induced tPA reduction in cells . Negative_regulation PLAT NOS3 15625301 1362090 In a mouse model of focal cerebral ischemia , [tPA] *induces* inhibition , ERK-2 activation , and p38 inhibition , possibly as part of a more complex signaling response exacerbating brain injury . Negative_regulation PLAT NTRK2 18815270 1970176 Treatment of rat hippocampal slices with the VGF derived peptide TLQP62 resulted in transient potentiation through a mechanism that was selectively blocked by the BDNF scavenger , the Trk tyrosine kinase inhibitor K252a ( 100 nm ) , and tPA STOP , an *inhibitor* of [tissue plasminogen activator (tPA)] , an enzyme involved in pro-BDNF cleavage to BDNF , but was not blocked by the NMDA receptor antagonist APV , anti-p75 ( NTR ) function blocking antiserum , or previous tetanic stimulation . Negative_regulation PLAT OSM 9863709 556134 On human umbilical vein endothelial cells , *induced* an increase in PAI-1 and a decrease in [tPA] secretion , which could explain the thrombogenicity of oncostatin M on large vessels . Negative_regulation PLAT OXA1L 24417965 2917880 This proof-of-principle study suggests that the activity of [tPA] can be *suppressed* by and regenerated by thrombin present at the thrombus . Negative_regulation PLAT PAGR1 1745999 172001 [tissue plasminogen activator] *inhibitor* ( ) activity , 9.1 ( 5.5-19.3 ) vs 5.1 ( 1.8-12.0 ) IU/ml , p less than 0.002 ; Negative_regulation PLAT PAGR1 2418059 56130 The thrombin induced *inhibited* both [tPA] and urokinase , did not lose activity upon acidification , and was stable to sodium dodecyl sulfate and thiol reduction . Negative_regulation PLAT PAGR1 2833945 91272 The *inhibited* the [tissue-type plasminogen activator] , and also that of the two-chain form of urokinase , but not the one-chain form . Negative_regulation PLAT PAGR1 3484963 57646 The content of [tissue plasminogen activator] *inhibitor* ( ) , and of specific pregnancy plasma-PA-I reacting with antibodies to placental-PA-I , was measured in platelet-poor plasma ( PPP ) , platelet-rich plasma (PRP) , serum and platelet lysate , both from pregnant women and healthy non-pregnant ( male or female ) controls . Negative_regulation PLAT PLAT 11797019 892452 After blood sampling we measured activation markers of fibrinolysis [ plasmin/alpha(2)-antiplasmin complexes ( PAP ) , complexes of [tissue plasminogen activator/plasminogen] activator *inhibitor* ( ) , fibrin(ogen) degradation products ( FDPs ) , D-dimmers fibrin degradation products ( D-d ) ] , the utilization marker of antithrombin III (ATIII) thrombin/antithrombin complexes (TAT) , several factors of fibrinolysis [ plasminogen , tissue plasminogen activator (tPA) , plasminogen activator inhibitor 1 ( PAI-1 ) , alpha(2)-antiplasmin ] , and the natural coagulation inhibitors [ ATIII , protein C (PrC) , protein S (PrS) ] . Negative_regulation PLAT PLAT 11929177 927233 We measured plasma levels of thrombin antithrombin III complex (TAT) , fibrinopeptide A ( FPA ) , [tissue plasminogen activator-plasminogen] activator *inhibitor* ( ) : markers of coagulation-fibrinolysis-system , and also beta-thromboglobulin ( beta-TG ) : a marker of platelet activation , in 40 COPD patients and in 20 control subjects . Negative_regulation PLAT PLAT 15366789 1294714 The plasma levels of plasminogen activator inhibitor-1 ( PAI-1 ) antigen , [tissue plasminogen activator] *inhibitor* ( ) antigen , thrombomodulin (TM) , tissue factor pathway inhibitor (TFPI) antigen , and fibrinogen were determined before and after 6 months of therapy . Negative_regulation PLAT PLAT 8888658 391620 Hormone replacement therapy in postmenopausal women has been shown to enhance fibrinolytic capacity by lowering plasminogen activator inhibitor-1 ( PAI-1 ) and [tissue plasminogen activator] *inhibitor* ( ) antigen values . Negative_regulation PLAT PLAU 7711210 298035 TGF alpha increased basal [tPA] activity at both stages of follicular development but *inhibited* activities of in undifferentiated granulosa cells , irrespective of the presence of FSH . Negative_regulation PLAT PLD1 15716416 1374104 We now show that overexpression of wild-type in cultured neurons *promotes* [tPA] release and tPA dependent neurite extension , whereas overexpression of an inactive PLD1 allele or pharmacological inhibition of PLD1 inhibits tPA release . Negative_regulation PLAT PLG 10333090 614923 A concomitant enhancement of tissue activity *resulted* in significant increases in tissue plasminogen activity antigen and total fibrin/fibrinogen degradation products , and a significant decrease in [tissue plasminogen activator] inhibitor-1 activity . Negative_regulation PLAT PLG 10633006 576592 Transforming growth factor betadownregulated tissue plasminogen activator while upregulating type1 activator inhibitor , and platelet derived growth factor *enhanced* [tissue plasminogen activator] expression in E-15 fibroblasts . Negative_regulation PLAT PLG 10818128 693795 To gain insights into the possible actions of plasmin , we evaluated the hypotheses that [tPA] and plasmin may *mediate* Abeta in vitro toxicity or , alternatively , that activation may lead to Abeta degradation . Negative_regulation PLAT PLG 12147618 970047 The serine proteases [tissue plasminogen activator (t-PA)] and urokinase plasminogen activator (u-PA) and their inhibitor , , *regulate* a variety of processes involved in tissue morphogenesis and differentiation . Negative_regulation PLAT PLG 16460337 1522603 The activities of tissue and urokinase activators ( tPA and uPA , respectively ) , the relative *inhibition* of [tPA] , and the amounts of plasminogen activator inhibitors 1 and 2 ( PAI-1 and PAI-2 , respectively ) in cell-free saliva were studied . Negative_regulation PLAT PLG 1737024 181842 An amount of PIXI which inhibited by 50 % factor XIa cleavage of the chromogenic substrate S2366 ( Pyr-Glu-Pro-Arg-pNA-2H2O ) only slightly inhibited ( 5-9 % ) factor XIIa , plasma kallikrein , , and activated protein C and did not *inhibit* factor Xa , thrombin , [tPA] , or trypsin , suggesting specificity for factor XIa . Negative_regulation PLAT PLG 17379720 1715311 Strain ST1 of L. crispatus *enhanced* activation of human Plg by the [tissue-type Plg activator (tPA)] , whereas enhancement of the urokinase mediated activation was lower . Negative_regulation PLAT PLG 2143947 140040 Transplacental effect of lead compounds on [tissue plasminogen activator] activity , plasminogen activator inhibition and *inhibition* . Negative_regulation PLAT PLG 2147015 144093 Effect of orchidectomy on [tissue plasminogen activator] activity , activator *inhibition* and plasmin inhibition . Negative_regulation PLAT PLG 2349543 135103 Variable effect of unilateral or bilateral ovariectomy performed in young or adult animals on [tissue plasminogen activator] activity , activator *inhibition* and plasmin inhibition . Negative_regulation PLAT PLG 2526669 115268 In the *presence* of , tPA also causes a [tPA] dose dependent inhibition of thrombin- and ionophore A23187 stimulated PGI2 production . Negative_regulation PLAT PLG 2532794 123249 The effect of experimental chronic hypertension on [tissue plasminogen activator] activity , activator *inhibition* and plasmin inhibition . Negative_regulation PLAT PLG 2579638 46198 Evidence is presented indicating that binding to the active site of urokinase ( KD = 2.0 mM ) is responsible for the inhibition of the urokinase system , binding to the active site of [tissue-plasminogen activator] is approx. 100-fold weaker , and inhibition of the tissue-plasminogen activator system , when monitored by plasmin activity , is mainly *due* to inhibition . Negative_regulation PLAT PLG 6448164 11966 The effect of the anabolic steroid stanozolol on [tissue plasminogen activator] activity and *inhibition* in the rat . Negative_regulation PLAT PLG 7607578 311845 Circadian variations of plasminogen activator activity , [tissue-type plasminogen activator] antigen , activator *inhibition* and plasmin inhibition in rat aorta , heart and brain are influenced by endotoxin or aspirin or endotoxin plus aspirin . Negative_regulation PLAT PLG 7818846 285377 It was observed that binding of [tPA] to the 45-kDa protein was *reduced* by and vice versa . Negative_regulation PLAT PLG 8836361 386258 To evaluate the ability of commercial , chromogenic kits designed to measure human fibrinolytic pathway components to measure the canine plasma fibrinolytic pathway enzymes , [tissue plasminogen activator (tPA)] and plasminogen (PLG) , and their respective *inhibitors* , and alpha 2-antiplasmin (AP) . Negative_regulation PLAT PLG 8857956 388373 In experiments using anti-actin antibodies added in excess to cultured ECs , binding of was inhibited by 45 % , [tPA] binding was *inhibited* by 46 % and Lp(a) binding was reduced by 56 % , confirming actin as a binding site for these various ligands whilst attesting to the presence of other EC receptors for these proteins . Negative_regulation PLAT PRL 10959408 726246 In support of this hypothesis we have shown that both and GH *inhibit* [tPA] activity and plasminogen activation in the involuting mammary gland . Negative_regulation PLAT PRL 11324510 479817 *inhibition* of FSH induced [tissue type plasminogen activator] expression in cultured rat granulosa cells . Negative_regulation PLAT PRL 16720715 1565302 *inhibited* gene expression of matrix metalloproteinases ( MMPs ) 3 and 12 but not [tissue plasminogen activator] or plasmin in wild-type and transgenic animals . Negative_regulation PLAT PRL 9455847 475591 also *suppressed* HCG induced [tPA] gene expression in a dose- and time dependent manner . Negative_regulation PLAT PROC 1737024 181843 An amount of PIXI which inhibited by 50 % factor XIa cleavage of the chromogenic substrate S2366 ( Pyr-Glu-Pro-Arg-pNA-2H2O ) only slightly inhibited ( 5-9 % ) factor XIIa , plasma kallikrein , plasmin , and and did not *inhibit* factor Xa , thrombin , [tPA] , or trypsin , suggesting specificity for factor XIa . Negative_regulation PLAT PSIP1 1462839 206718 C and incompletely *inhibited* the fibrinolytic activity of [tPA] by the active PAI . Negative_regulation PLAT RHO 17245169 1690810 The protein inhibitor *increased* [tPA] production and rescued tPA production from the inhibitory effect of GGPP . Negative_regulation PLAT S100A1 15257287 1274347 siRNA mediated downregulation of annexin and disruption of the complex by microinjection of peptide competitors *result* in a marked reduction in vWF but not [tPA] secretion , without affecting the appearance of WPbs . Negative_regulation PLAT SDS 9364046 462975 In vitro , neuroserpin formed complexes and *inhibited* the amidolytic activity of [tissue plasminogen activator] , urokinase , and plasmin . Negative_regulation PLAT SERPINB2 10215917 608236 Up-regulation of tPA expression by BDNF is followed by the induction of ( PAI-2 ) , an *inhibitor* of [tPA] . Negative_regulation PLAT SERPINB2 15312091 1285166 [Tissue plasminogen activator (t-PA)] and placental plasminogen activator *inhibitor* ( ) in gingival crevicular fluid from patients with Papillon-Lefèvre syndrome . Negative_regulation PLAT SERPINB2 15312091 1285168 The concentration of [tissue plasminogen activator (t-PA)] and *inhibitor* ( ) was measured with ELISA . Negative_regulation PLAT SERPINB2 15944795 1416342 The plasminogen activator (PA) system comprises the 2 serine proteases , urokinase PA (uPA) and [tissue PA (tPA)] , the 2 serpin *inhibitors* , PAI-1 and and the uPA receptor ( uPAR ; Negative_regulation PLAT SERPINB2 16433079 1495214 The aim of this study was to investigate gingival crevicular fluid (GCF) levels of [tissue plasminogen activator (t-PA)] and plasminogen activator *inhibitor* ( ) during orthodontic tooth movement in adults . Negative_regulation PLAT SERPINB2 16611153 1545296 The central components of the PA system are the proteolytic activators , urokinase-plasminogen activator (u-PA) and [tissue-type plasminogen activator (t-PA)] , plasminogen (plg) and its degradation product , plasmin , together with the major *inhibitors* of this system , ( PAI-1 , PAI-2 ) . Negative_regulation PLAT SERPINB2 18690354 1949452 Here we show that can *inhibit* cell bound [tPA] activity in vitro and thus prevent plasmin formation . Negative_regulation PLAT SERPINB2 20887517 2326815 GCF levels of [tissue type plasminogen activator (t-PA)] and its *inhibitor* , ( PAI-2 ) were determined by ELISA . Negative_regulation PLAT SERPINB2 3091604 62520 The was inactive towards single-chain urokinase-type plasminogen activator and plasmin , but it *inhibited* two-chain [tissue-type plasminogen activator] with a k below 10 ( 3 ) M-1 s-1 and thrombin with a k of 4 X 10(4) M-1 s-1 in the absence and 2 X 10 ( 5 ) M-1 s-1 in the presence of heparin . Negative_regulation PLAT SERPINB2 8111706 246212 In this study , we measured the antigen levels of urokinase ( u-PA ) , [tissue plasminogen activator (t-PA)] , type 1 plasminogen activator inhibitor ( PAI-1 ) , and type 2 plasminogen activator *inhibitor* ( ) , and cancer tissue ( 19 adenocarcinomas and 19 squamous cell carcinomas ) and normal lung tissue . Negative_regulation PLAT SERPINB2 8248729 237385 [Tissue plasminogen activator (t-PA)] and placental plasminogen activator *inhibitor* ( ) in gingival fluid from 8-9-year-old children . Negative_regulation PLAT SERPINB5 10987285 732443 Despite the recent biochemical evidence that specifically *inhibits* [tissue-type plasminogen activator] that is associated with fibrinogen or poly-L-lysine , the molecular mechanism underlying the tumor-suppressive effect of maspin remains elusive . Negative_regulation PLAT SERPIND1 16038721 1437454 Expression of by infection of adenovirus vector *inhibited* thrombin induced [tissue-type plasminogen activator] and interleukin-6 releases from fibroblasts and thrombin induced interleukin-6 release from vascular smooth muscle cells . Negative_regulation PLAT SERPIND1 2122537 143921 *inhibits* thrombin stimulated release of [tissue plasminogen activator] from cultured human endothelial cells in the presence of dermatan sulfate . Negative_regulation PLAT SERPINE1 10066364 593553 Regulation of [tissue-type plasminogen activator] and its *inhibitor* ( ) by lipopolysaccharide induced phagocytosis in a Sertoli cell line . Negative_regulation PLAT SERPINE1 10364094 620339 The increased incidence of cardiovascular diseases in obese subjects could be partially attributed to impaired fibrinolysis due to elevated plasma levels of [tissue plasminogen activator] *inhibitor* 1 ( ) . Negative_regulation PLAT SERPINE1 10368124 621693 ( PAI-1 ) , a rapid *inhibitor* of [tPA] , may contribute to arterial thrombolysis resistance . Negative_regulation PLAT SERPINE1 10442549 635671 The expression of tissue factor ( TF ) , tissue factor pathway inhibitor (TFPI) , von Willebrand factor (vWF) , endothelial nitric oxide (NO) synthase ( eNOS ) , [tissue plasminogen activator (tPA)] , its *inhibitor* ( ) , and myosin , an indicator of local shear stress , was examined in the endothelium of cerebral vessels according to vessel size and location in human autopsy brains , using immunohistochemistry . Negative_regulation PLAT SERPINE1 10469853 641366 In 76 HD patients ( prevalent CVD , 44 of 76 patients ) , serum lipid , lipoprotein , apolipoprotein (Apo) , plasma fibrinogen , [tissue plasminogen activator (TPA)] , plasminogen activator *inhibitor* ( ) , and factor VII levels were measured using standard kits . Negative_regulation PLAT SERPINE1 10515502 652007 The tPA activity , tPA antigen and [tPA] *inhibitor* 1 ( ) antigen were determined in the supernatant of transduced ( BBEC/tPA ) cell cultures by an immunoassay . Negative_regulation PLAT SERPINE1 10691096 670600 Antigen levels of [tissue-type plasminogen activator] ( tPA ) and plasminogen activator *inhibitor* ( ) were comparable with young endothelial cells , and mRNA was present for tPA , PAI-1 , tissue factor ( TF ) , tissue factor pathway inhibitor and thrombomodulin . Negative_regulation PLAT SERPINE1 10780315 687578 We studied the effects of fluvastatin and bezafibrate in monotherapy and in combination on plasma fibrinogen , [t-plasminogen activator] *inhibitor* ( ) and C reactive protein (CRP) in patients with coronary artery disease ( CAD ) and mixed hyperlipidaemia . Negative_regulation PLAT SERPINE1 10806767 478674 Plasma [tissue-type plasminogen activator] ( tPA ) and plasminogen activator *inhibitor* ( ) and lipoprotein(a) [ Lp(a) ] in 133 healthy subjects were determined . Negative_regulation PLAT SERPINE1 10907030 407171 [ [Tissue plasminogen activator] antigen ( t-PA Ag ) and tissue plasminogen activator *inhibitor* ( ) in the course of hemodialysis in patients with chronic renal failure ] . Negative_regulation PLAT SERPINE1 10907030 407172 In 10 patients with chronic renal insufficiency we are tissue plasminogen activator antigen ( t-PA Ag ) , [tissue plasminogen activator] *inhibitor* ( ) and euglobulin lysis time ( ELT ) designed . Negative_regulation PLAT SERPINE1 10959708 726294 Neither the morphology of the cells nor the secretion of prostacyclin ( PGI2 ) , von Willebrand factor (vWF) , [tissue plasminogen activator (t-PA)] and plasminogen activator *inhibitor* ( ) was affected by the crosslink density of the collagen substrate . Negative_regulation PLAT SERPINE1 10997795 734099 Experimental and clinical research supports a direct link between activation of the renin-angiotensin system and production of ( PAI-1 ) , the primary physiologic *inhibitor* of [tissue plasminogen activator] . Negative_regulation PLAT SERPINE1 11107162 756663 The present study underscores a regulatory role of intracellular ceramide in astrocytes for the release of an extracellular serine protease , [tissue-type plasminogen activator (t-PA)] , and its *inhibitor* , ( PAI-1 ) . Negative_regulation PLAT SERPINE1 11190905 779547 The plasma levels of von Willebrand factor , [tissue plasminogen activator (TPA)] , plasminogen activator *inhibitor* ( ) , and the TPA-PAI-1 complex were significantly increased in TTP/HUS patients ; Negative_regulation PLAT SERPINE1 11263957 796483 We describe the expression of [tissue-type plasminogen activator (t-PA)] and plasminogen activator *inhibitor* ( ) in saphenous vein culture . Negative_regulation PLAT SERPINE1 11340346 812484 We examined plasma and urine concentrations of [tissue-type plasminogen activator] ( tPA ) and type 1 plasminogen activator *inhibitor* ( ) in 33 patients with nephrotic syndrome ( nephrotic group ) . Negative_regulation PLAT SERPINE1 11372681 817774 Increased levels of ( PAI-1 ) , the main physiological *inhibitor* of [tissue-type plasminogen activator (t-PA)] in plasma , are a known risk factor for thromboembolic and cardiovascular diseases . Negative_regulation PLAT SERPINE1 11503186 847787 In diabetic patients with microangiopathy significantly higher N-acetyl-beta-glucosaminidase (NAG) activities in serum and E-selection or ICAM-1 concentrations were found as compared with patients without microangiopathy , whereas plasma concentrations of [tissue plasminogen activator (tPA)] or *inhibitor* ( ) were comparable with those in the control group . Negative_regulation PLAT SERPINE1 11797019 892451 After blood sampling we measured activation markers of fibrinolysis [ plasmin/alpha(2)-antiplasmin complexes ( PAP ) , complexes of [tissue plasminogen activator/plasminogen] activator *inhibitor* ( ) , fibrin(ogen) degradation products ( FDPs ) , D-dimmers fibrin degradation products ( D-d ) ] , the utilization marker of antithrombin III (ATIII) thrombin/antithrombin complexes (TAT) , several factors of fibrinolysis [ plasminogen , tissue plasminogen activator (tPA) , plasminogen activator inhibitor 1 ( PAI-1 ) , alpha(2)-antiplasmin ] , and the natural coagulation inhibitors [ ATIII , protein C (PrC) , protein S (PrS) ] . Negative_regulation PLAT SERPINE1 11812405 907255 Levels or presence of protein C , protein S , antithrombin , methylenetetrahydrofolate reductase C677T , factor V Leiden , prothrombin gene G20210A , antiphospholipid antibodies , plasminogen , [tissue-type plasminogen activator] ( tPA ) , type-1 tPA *inhibitor* ( ) , PAI-1 4G/5G polymorphism , prothrombin fragment 1+2 , plasmin/alpha(2)-antiplasmin complexes , thrombomodulin , and activated factors VII and XII were determined . Negative_regulation PLAT SERPINE1 11821716 908897 Tissue plasminogen activator (t-PA) and [tissue plasminogen activator] *inhibitor* ( ) activities were measured . Negative_regulation PLAT SERPINE1 11929177 927232 We measured plasma levels of thrombin antithrombin III complex (TAT) , fibrinopeptide A ( FPA ) , [tissue plasminogen activator-plasminogen] activator *inhibitor* ( ) : markers of coagulation-fibrinolysis-system , and also beta-thromboglobulin ( beta-TG ) : a marker of platelet activation , in 40 COPD patients and in 20 control subjects . Negative_regulation PLAT SERPINE1 12152654 971403 ( PAI-1 ) , the primary physiological *inhibitor* of both [tissue-type plasminogen activator] and urokinase-type plasminogen activator in plasma , is a well established risk factor in thrombotic diseases . Negative_regulation PLAT SERPINE1 12192463 980872 *inhibits* [tissue plasminogen activator] and urokinase-type plasminogen activator , resulting in reduced plasminogen activity and attenuated fibrinolysis and proteolysis . Negative_regulation PLAT SERPINE1 12371961 996211 By expressing the fibrinolytic enzyme [tissue-type plasminogen activator (t-PA)] and its specific *inhibitor* , ( PAI-1 ) , human peritoneal mesothelial cells ( HMC ) play an important role in regulating peritoneal fibrinolysis . Negative_regulation PLAT SERPINE1 12388238 1031290 We used electron microscopy and immunoconfocal ( IF ) labeling for bFGF , matrix metalloproteinase (MMP)-2 , MMP-9 , [tissue-type plasminogen activator] ( tPA ) , its *inhibitor* ( ) , fibronectin (FN) , and Ki-67 . Negative_regulation PLAT SERPINE1 12567428 581578 When different concentration of 17 beta-estrodial including 10 ( -10 ) mol/L ( the group E1 ) , 10 ( -8 ) mol/L ( the group E2 ) , 10 ( -6 ) mol/L ( the group E3 ) were treated in original cultured HUVEC , the changes of [tissue plasminogen activator (t-PA)] and plasminogen activator *inhibitor* ( ) were measured by spectrophotometric assay , and the level of message RNA were examined by in situ hybridization . Negative_regulation PLAT SERPINE1 12637546 1085427 In vascular injury models , Serp-1 altered early cellular plasminogen activator ( [tissue plasminogen activator] ) , *inhibitor* ( ) , and receptor ( urokinase-type plasminogen activator ) expression ( p < 0.01 ) . Negative_regulation PLAT SERPINE1 12642921 1030240 In addition to these metabolic changes there are also other laboratory deviations , manifested e.g. by hyperfibrinogenaemia and an increased concentration of [tPA] *inhibitor* ( ) without detectable endothelial dysfunction . Negative_regulation PLAT SERPINE1 12724002 1084240 Multivariate genetic analysis was performed using a total of 314 ( 107 monozygotic and 207 dizygotic ) twin pairs on IR assessed by HOMA , fibrinogen , plasminogen activator *inhibitor* ( ) , [tissue plasminogen activator (tPA)] , factor VIII (FVIII) , von Willebrand factor (vWF) and factor XIII B-subunit . Negative_regulation PLAT SERPINE1 12738955 1088052 The supernatants of Porphyromonas endodontalis , Porphyromonas gingivalis , and Prevotella intermedia were used to evaluate [tissue-type plasminogen activator (t-PA)] and type 1 plasminogen activator *inhibitor* ( ) gene expression in human pulp and osteoblastic cells . Negative_regulation PLAT SERPINE1 12753293 1089651 Human peritoneal mesothelial cells ( HMC ) play a critical role in maintaining the intraperitoneal balance between fibrinolysis and coagulation by expressing the fibrinolytic enzyme [tissue-type plasminogen activator (t-PA)] and its specific *inhibitor* , ( PAI-1 ) as well as the procoagulant protein , tissue factor . Negative_regulation PLAT SERPINE1 1280377 203143 The levels of [tissue-type plasminogen activator (t-PA)] , type 1 plasminogen activator *inhibitor* ( ) , and t-PA/PAI-1 complex antigens were analyzed in the plasma of disseminated intravascular coagulation ( DIC ) patients and healthy controls . Negative_regulation PLAT SERPINE1 1285345 208716 The effects of cyclic strain on the production of [tissue plasminogen activator (tPA)] and type 1 plasminogen activator *inhibitor* ( ) by cultured endothelial cells ( EC ) were examined . Negative_regulation PLAT SERPINE1 12868191 1112098 Fibrinolysis was assessed by measurement of [tissue plasminogen activator (t-PA)] and tissue plasminogen activator *inhibitor* ( ) concentrations , whereas activation of thrombinogenesis was detected by F1 + 2 prothrombin fragment concentration . Negative_regulation PLAT SERPINE1 12917724 1031039 The study group consisted of 31 patients ( 17 males , mean age 62 years , and 14 females , mean age 60.6 years ) with ACS and without ST segment elevation in whom antibodies to C. pneumoniae and such haemostatic factors as von Willebrand factor (vWF) , thrombomodulin (TM) , [tissue plasmin activator (tPA)] , tPA *inhibitor* ( ) and fibrinogen were measured . Negative_regulation PLAT SERPINE1 1328751 197933 In this study , we report the effects of recombinant human TNF alpha on the synthesis of [tissue-type plasminogen activator (t-PA)] and its *inhibitor* ( ) by human mesangial cells in culture . Negative_regulation PLAT SERPINE1 1339823 209230 The concentrations of [tissue plasminogen activator (t-PA)] , urokinase plasminogen activator (u-PA) and plasminogen activator *inhibitor* ( ) have been determined in endometrial curettings obtained from 46 subfertile women during proliferative , early or late secretory phases of the menstrual cycle . Negative_regulation PLAT SERPINE1 1368117 176475 Confluent monolayers were stimulated by human recombinant interleukin ( IL-1 beta ) and responses in terms of tissue factors like procoagulant activity , [tissue plasminogen activator (tPA)] and plasminogen activator *inhibitor* ( ) were followed for up to 72 h. Procoagulant activity of cell extracts displayed similar patterns whatever the substratum tested . Negative_regulation PLAT SERPINE1 1375108 186373 ( PAI-1 ) , the major physiologic *inhibitor* of [tissue plasminogen activator (tPA)] , plays a crucial role in the regulation of fibrinolysis . Negative_regulation PLAT SERPINE1 1382596 198284 ( PAI-1 ) , the principal physiological *inhibitor* of [tissue plasminogen activator (tPA)] , is a protein of 379 amino acids and belongs to the SERPIN family of serine protease inhibitors . Negative_regulation PLAT SERPINE1 1394930 198903 Immunological and functional levels of [tissue-type plasminogen activator (t-PA)] and type 1 plasminogen activator *inhibitor* ( ) were quantified in platelet-poor plasma ( PPP ) from patients with CTEPH as well as age matched controls . Negative_regulation PLAT SERPINE1 1425641 202294 Concentrations of the fibrin degradation products ( FbDP ) and fibrinogen degradation products (FgDP) were significantly higher in the runners than in the control group , indicating an increased fibrinolytic potential that seemed to be a consequence of the reduced formation of [tissue plasminogen activator-plasminogen] activator *inhibitor* ( ) complexes . Negative_regulation PLAT SERPINE1 1455397 206289 Before occlusion plasma levels of [tissue-type plasminogen activator (t-PA)] antigen and its *inhibitor* ( ) were significantly higher in the patient group ( p < 0.001 ) . Negative_regulation PLAT SERPINE1 14623266 1169330 In a biochemical assay determining direct tPA activity , human recombinant completely *inhibited* [tPA] , but this inhibition was blocked by WAY-140312 at an IC ( 50 ) of 15.6 microM . Negative_regulation PLAT SERPINE1 14624049 1169991 In the patients and in 25 control subjects , plasma levels of [tissue-type plasminogen activator] , plasminogen activator *inhibitor* ( ) , D-dimer , prothrombin fragment 1 + 2 (F1 + 2) , total cholesterol , triglycerides and fibrinogen had been measured . Negative_regulation PLAT SERPINE1 14669449 1178235 [[Tissue-type plasminogen activator] ( T-PA ) and plasminogen activator *inhibitor* ( ) in human follicular fluid during gonadotropin induced ovulation ] . Negative_regulation PLAT SERPINE1 14697941 1180481 The aim of the study was to evaluate associations between some fibrinolytic factors : antigens of [tissue-type plasminogen activator (t-PA)] , plasminogen activator *inhibitor* ( ) , and thrombin-activatable fibrinolysis inhibitor ( TAFI ) , and IMT in a population of renal transplant recipients . Negative_regulation PLAT SERPINE1 14718902 1197634 Fibrinolysis was determined by [tissue plasminogen activator (tPA)] , plasminogen activator *inhibitor* ( ) and fibrin degradation product ( D-dimer ) . Negative_regulation PLAT SERPINE1 14730909 1181917 The antithrombotic mechanism of novel compounds is not relevant to hemostatic systems or functions of platelet aggregation directly , but they can promote endothelial cells to release [tissue-type plasminogen activator (t-PA)] and *inhibit* the activity of ( PAI-1 ) . Negative_regulation PLAT SERPINE1 14988411 1236684 As ( PAI-1 ) , the physiological *inhibitor* of [tissue-type plasminogen activator] , is considered to be an important risk factor in several ( patho ) physiological conditions , many research activities focus on attempts to inhibit this serpin . Negative_regulation PLAT SERPINE1 1537879 180628 We have previously shown that alpha-thrombin exerted a mitogenic effect on human glomerular epithelial cells and stimulated the synthesis of urokinase-type ( u-PA ) and [tissue-type plasminogen activator (t-PA)] and of their *inhibitor* , ( PAI-1 ) . Negative_regulation PLAT SERPINE1 15467309 1305764 Bleeding time , platelet count , prothrombin time , activated partial thromboplastin time , [tissue plasminogen activator (tPA)] , plasminogen activator *inhibitor* ( ) , euglobulin clot lysis time , protein C , protein S , fibrinogen , D-dimer , factor V , VII , VIII , IX , X and von Willebrand factor (VWF) values were studied at the beginning , at 2 and 4 h of dialysis with and without administration of DDAVP at a dose level of 2 microg/kg intranasally . Negative_regulation PLAT SERPINE1 15604328 1356836 To investigate the effects of short term atorvastatin treatment on forearm vasodilatory response to reactive hyperaemia ( RH % ) and on components of the thrombosis-fibrinolysis system ( antithrombin III , proteins and S , factors V and VII , von Willebrand factor , [tissue plasminogen activator (tPA)] , and plasminogen activator *inhibitor* ( ) ) in patients with heart failure . Negative_regulation PLAT SERPINE1 15670033 1365823 In them , and in an equal number of controls , plasma levels of immunoreactive [tissue plasminogen activator (tPA)] , plasminogen activation *inhibitor* 1 ( ) , von Willebrand factor (VWF) , fibrinogen , D-dimer and CRP were measured . Negative_regulation PLAT SERPINE1 15804733 1390938 CEE decreased the antigen levels of [tissue plasminogen activator (t-PA)] from 8.8 to 6.8 U/ml ( p < 0.001 ) , and of plasminogen activator *inhibitor* ( ) from 30.8 to 21.6 U/ml ( p < 0.010 ) , whereas raloxifene had no significant effect on either t-PA , from 9.6 to 9.2 U/ml ( p = 0.235 ) or PAI-1 antigen levels , from 32.1 to 30.4 U/ml ( p = 0.538 ) . Negative_regulation PLAT SERPINE1 15944795 1416341 The plasminogen activator (PA) system comprises the 2 serine proteases , urokinase PA (uPA) and [tissue PA (tPA)] , the 2 serpin *inhibitors* , and PAI-2 and the uPA receptor ( uPAR ; Negative_regulation PLAT SERPINE1 15988036 1429277 Here , we report that prostate carcinoma cells LNCaP and PC3 autoactivate latent full-length PDGF D into its active form under serum independent conditions and that this autoactivation is inhibited by , a urokinase plasminogen activator [(uPA)/tissue plasminogen activator (tPA)] *inhibitor* . Negative_regulation PLAT SERPINE1 1601844 189089 ( PAI-1 ) , the primary physiological *inhibitor* of [tissue-type plasminogen activator (t-PA)] in plasma , is a serine proteinase inhibitor ( serpin ) that forms a 1 : 1 stoichiometric complex with its target proteinase leading to the formation of a stable inactive complex . Negative_regulation PLAT SERPINE1 1623118 191513 The aim of the present study was to compare plasma levels of urokinase-type plasminogen activator ( u-PA ) , before and after 20 min of venous stasis , with those of [tissue-type plasminogen activator (t-PA)] , type 1 plasminogen activator *inhibitor* ( ) and t-PA/PAI-1 complexes , to determine whether both plasminogen activators and their inhibitor respond similarly to the same stimulus . Negative_regulation PLAT SERPINE1 16273765 1479724 We have studied [tissue-type plasminogen activator (t-PA)] and its *inhibitor* ( ) , and d-dimer levels in BS patients with and without thrombosis both in the acute and chronic phases along with suitable diseased and healthy controls . Negative_regulation PLAT SERPINE1 1628764 191809 Therefore , we measured markers of free radical activity ( nonperoxide conjugated diene isomer of linoleic acid [ PL-9,11-LA ' ] and lipid peroxides expressed as malondialdehyde [ MDA ] ) along with the hemostatic variables : fibrinogen , von Willebrand factor (vWf) , plasminogen activator *inhibitor* ( ) , [tissue plasminogen activator (t-PA)] , and plasmin activity ( B beta 15-42 ) in 24 NIDDM patients ( 12 patients with microalbuminuria and 12 without microalbuminuria ) and in 12 age matched control subjects . Negative_regulation PLAT SERPINE1 16297317 1484735 With prolongation of I/R , the contents of Col IV and LN decreased in both young and aged rats , while the contents of [tissue plasminogen activator (t-PA)] , urokinase plasminogen ( u-PA ) and plasminogen activator *inhibitor* ( ) expression increased at the beginning and decreased subsequently . Negative_regulation PLAT SERPINE1 16309851 1502942 A study of the serum levels of the ( PAI-1 ) , the major *inhibitor* of [tPA] , found that women with MDD had a higher PAI-1 concentration than normal controls . Negative_regulation PLAT SERPINE1 16369213 1493361 We summarize the data on the role of leptin , adiponectin , the growth hormone axis , glucocorticoids , sterol response element binding protein 1c ( SREBP-1c ) , the tumor necrosis factor alpha axis ( TNF-alpha ) , interleukin-6 (IL-6) , interleukin- 18 (IL-18) , interferon-alpha (IFN-alpha) , [tissue plasminogen activator (tPA)] , and plasminogen activator *inhibitor* ( ) in the pathophysiology of LD . Adiponectin levels are generally decreased in LD , whereas leptin levels are increased . Negative_regulation PLAT SERPINE1 16611153 1545295 The central components of the PA system are the proteolytic activators , urokinase-plasminogen activator (u-PA) and [tissue-type plasminogen activator (t-PA)] , plasminogen (plg) and its degradation product , plasmin , together with the major *inhibitors* of this system , and -2 ( PAI-1 , PAI-2 ) . Negative_regulation PLAT SERPINE1 16708119 1564246 Plasma von Willebrand factor antigen (vWF:Ag) , thrombomodulin , [tissue-type plasminogen activator (t-PA)] and its *inhibitor* ( ) , and D-dimer were determined by immunoenzymatic assay at baseline , and at 6 , 12 , and 18 months . Negative_regulation PLAT SERPINE1 1670989 151271 ( PAI-1 ) , a rapid *inhibitor* of [tissue-type plasminogen activator] , has been shown to be an independent risk factor for recurrent myocardial infarction ( MI ) at a young age . Negative_regulation PLAT SERPINE1 16780267 1573416 The aim of the study was the assessment of [tissue plasminogen activator (t-PA)] and its *inhibitor* ( ) in children with ulcerative colitis . Negative_regulation PLAT SERPINE1 1701436 145034 ( PAI-1 ) *inhibits* the [tissue plasminogen activator (tPA)] and urokinase activation of plasminogen to plasmin , a protease of trypsin-like specificity which is involved in a number of processes , including fibrinolysis , matrix degradation and angiogenesis . Negative_regulation PLAT SERPINE1 17097821 1716649 In vitro studies have demonstrated that statins can induce tPA and inhibit , the major *inhibitor* of [tPA] . Negative_regulation PLAT SERPINE1 17181930 1662657 Plasma plasminogen activator *inhibitor* ( ) , [tissue plasminogen activator (t-PA)] antigens ( Ag ) and high sensitive C-reactive protein ( hs-CRP ) levels were measured during low salt intake at baseline . Negative_regulation PLAT SERPINE1 1718809 169405 In most patients , the increase in tissue-type plasminogen activator was counterbalanced by the increased levels of , but in a subgroup of patients the change in balance *resulted* in extremely high [tissue-type plasminogen-activator] levels . Negative_regulation PLAT SERPINE1 1719003 169482 However , it did not significantly modulate urokinase-type plasminogen activator ( u-PA ) , [tissue-type plasminogen activator (t-PA)] , plasminogen activator *inhibitor* ( ) , and tissue factor ( TF ) . Negative_regulation PLAT SERPINE1 17223725 1888660 Fibrinolysis was estimated by [tissue plasminogen activator (tPA)] and its *inhibitor* ( ) . Negative_regulation PLAT SERPINE1 1725834 176836 Concentrations of free plasminogen activator *inhibitor* ( ) and complex of [tPA-PAI-1] decreased from 8 : 30 to 16 : 30 . Negative_regulation PLAT SERPINE1 17491674 1358609 The following hemostatic parameters were measured : fibrinogen (Fb) , factor VII ( fVII ) , antithrombin III (ATIII) , C protein ( pC ) , [tissue plasminogen activator] *inhibitor* ( ) and alpha 2 antiplasmin (alpha2 AP) . Negative_regulation PLAT SERPINE1 17498240 1739841 [tPA] protease *inhibitors* , or PMSF , did not alter either effect . Negative_regulation PLAT SERPINE1 17698368 1794508 All components of this proteolytic pathway , tissue plasminogen activator (tPA) , plasminogen , membrane receptor annexin II and [tPA] *inhibitor* ( ) , are constitutively expressed in uninjured SCG and increase significantly after SCG neuron axotomy . Negative_regulation PLAT SERPINE1 1776334 175787 Platelet aggregation and the plasma levels/activity of plasminogen activator ( [tPA] ) and its *inhibitor* ( ) were determined . Negative_regulation PLAT SERPINE1 17974273 1820567 In addition , T3A cells released more tissue factor ( TF ) , [tissue-type plasminogen activator (t-PA)] , plasminogen activator *inhibitor* ( ) and urine plasminogen activator ( u-PA ) than LSEC in response to TNFalpha . Negative_regulation PLAT SERPINE1 1818784 177488 Recent studies have established that , of the known components of the fibrinolytic system , only [tissue-type plasminogen activator] ( tPA ) and its fast acting *inhibitor* , ( PAI-1 ) , show a marked circadian variation in plasma . Negative_regulation PLAT SERPINE1 1828764 158683 [Tissue plasminogen activator(tPA)] and plasminogen activator *inhibitor* ( ) were measured in citrated plasma samples before and after venous occlusion before and at the end of the study period . Negative_regulation PLAT SERPINE1 18295937 1951164 Levels of interleukin-6 (IL-6) , tumor necrosis factor alpha (TNF-alpha) , C-reactive protein (CRP) , fibrinogen (Fib) , plasminogen activator *inhibitor* ( ) , von Willebrand factor (vWF) and [tissue plasminogen activator (tPA)] were determined at baseline and 4 h after alcohol consumption . Negative_regulation PLAT SERPINE1 18559859 1929415 *inhibits* the activity of [tissue plasminogen activator (tPA)] , an enzyme that cleaves plasminogen to generate plasmin , a protease that degrades Abeta oligomers and monomers . Negative_regulation PLAT SERPINE1 18559859 1929417 Our data demonstrate that inhibitors *augment* the activity of [tPA] and plasmin in hippocampus , significantly lower plasma and brain Abeta levels , restore long-term potentiation deficits in hippocampal slices from transgenic Abeta producing mice , and reverse cognitive deficits in these mice . Negative_regulation PLAT SERPINE1 18846477 2028624 [Tissue plasminogen activator] antigen and plasminogen activator *inhibitor* ( activity ) and asymmetric dimethylargine ( ADMA ) were measured at baseline and after 2.5 years . Negative_regulation PLAT SERPINE1 1901356 155814 The work described here demonstrates the synthesis by human articular cartilage of ( PAI-1 ) , a potent *inhibitor* of the serine protease [tissue plasminogen activator (tPA)] . Negative_regulation PLAT SERPINE1 1902068 155926 [Tissue plasminogen activator (t-PA)] and its *inhibitor* ( ) were assessed in venous blood drawn before and after venous occlusion ( bvo , avo ) for 33 patients with Raynaud 's phenomenon ( RP ) , 14 with primary RP (PRP) , 9 with suspected secondary RP ( SSRP ) , and 10 with definite collagen disease and secondary RP (SRP) . Negative_regulation PLAT SERPINE1 1903823 159079 EC have been demonstrated to release [tissue type plasminogen activator (t-PA)] and its rapid inhibitor type 1 plasminogen activator *inhibitor* ( ) . Negative_regulation PLAT SERPINE1 1905594 161634 ( PAI-1 ) , the specific , fast acting *inhibitor* of [tissue-type plasminogen activator (t-PA)] , binds to fibrin and has been found in high concentrations within arterial thrombi . Negative_regulation PLAT SERPINE1 19100414 2004074 other hemostatic [parameters-tissue plasminogen activator (tPA)] and its *inhibitor* ( ) ; Negative_regulation PLAT SERPINE1 19126301 2019607 An ELISA ( enzyme linked immunosorbent assay ) was used to analyse ( [tissue-type plasminogen activator/plasminogen] activator *inhibitor* ) in the blood drawn from the rats with thrombosis . Negative_regulation PLAT SERPINE1 19566853 2104384 Peritoneal D-dimer concentration was determined , together with peritoneal [tissue-plasminogen activator (t-PA)] and plasminogen activator *inhibitor* ( ) activities . Negative_regulation PLAT SERPINE1 19718071 2231978 Serial coagulation and fibrinolytic activity markers were assessed , including prothrombin fragments 1+2 (F1+2) , thrombin time , D-dimer , [tissue-type plasminogen-activator] ( tPA ) and plasminogen-activator *inhibitor* ( ) . Negative_regulation PLAT SERPINE1 19920617 290071 We have extended these studies to determine whether the decrease in extracellular [tissue plasminogen activator] activity is the *result* of a decrease in the expression of tissue plasminogen activator , a change in the extracellular level of , or a combination of both . Negative_regulation PLAT SERPINE1 20051227 2200929 We tested the hypothesis that leptin induces and *inhibits* [tPA] expression using human coronary artery endothelial cells ( HCAEC ) in culture as these cells play an important role in atherosclerosis . Negative_regulation PLAT SERPINE1 20059881 2177486 VCAM-1 , ICAM-1 , E-selectin and P-selectin were used as markers of endothelium , [tissue plasminogen activator (tPA)] and its *inhibitor* ( ) as markers of fibrinolysis . Negative_regulation PLAT SERPINE1 20081060 2235374 We examined markers of thrombin generation and reactional fibrinolysis ( prothrombin fragment 1+2 (F1+2) , D-dimers , and plasmin antiplasmin complexes (P-AP) , and endothelial dysfunction [tissue plasminogen activator (t-PA)] , plasminogen activator *inhibitor* ( ) , soluble thrombomodulin ( sTM ) , intercellular adhesion molecule 1 ( sICAM-1 ) , vascular cell adhesion molecule ( sVCAM-1 ) , endothelial microparticles ( EMPs ) , and tissue factor pathway inhibitor (TFPI) . Negative_regulation PLAT SERPINE1 20472470 2388777 Blood samples were collected and genotyped for polymorphisms in platelet glycoprotein Iba (GPIba) rs224309 and rs6065 , glycoprotein IIIa (GPIIIa) rs5918 , [tissue plasminogen activator (tPA)] rs63020761 , plasminogen activating *inhibitor* ( ) rs72578597 , and cyclooxygenase-2 (COX-2) rs5275 and rs20417 . Negative_regulation PLAT SERPINE1 20508517 2283935 This study sought to examine whether circulatory levels of endothelial dysfunction biomarkers [ vascular cell adhesion molecule ( sVCAM-1 ) , intercellular adhesion molecule ( sICAM-1 ) , sE-selectin , von Willebrand factor (vWF) , [tissue plasminogen activator (t-PA)] and plasminogen activator *inhibitor* ( ) ] are associated with occurrence of late or very late stent thrombosis ( ST ) after percutaneous coronary intervention with sirolimus eluting stent implantation , and to assess the possible influence of genetic variants of these proteins on ST . Negative_regulation PLAT SERPINE1 20697946 2306028 ECs were cocultured with the serum for different time courses , and the culture supernatant concentrations of endothelin (ET)-1 , nitric oxide ( NO ) , [tissue-type plasminogen activator (t-PA)] , and plasminogen activator *inhibitor* ( ) were determined by ABC-ELISA methods . Negative_regulation PLAT SERPINE1 20798546 2324426 In our EVVSS model , the activity as well as the mRNA and protein expression levels of , the *inhibitor* of urokinase-type plasminogen activator ( uPA ) and [tissue-type plasminogen activator] ( tPA ) , were increased after 7 days of perfusion , whereas the expression levels of tPA and uPA were not altered . Negative_regulation PLAT SERPINE1 20823384 2318484 Elevated levels of ( PAI-1 ) , a potent *inhibitor* of urokinase plasminogen activator and [tissue plasminogen activator] , are implicated in the pathogenesis of tissue fibrosis . Negative_regulation PLAT SERPINE1 20889163 2381789 We measured the antigen levels of [tissue-type plasminogen activator (t-PA)] , plasminogen activator *inhibitors* 1 ( ) and 2 ( PAI-2 ) , and thrombin-activatable fibrinolysis inhibitor , as well as PAI-1 activity , in neonates at birth and on postnatal days 3 and 10 and in mothers at delivery . Negative_regulation PLAT SERPINE1 21082259 2407215 A case-control association study on 229 Myocardial Infarction ( MI ) patients and 217 healthy controls was carried out to determine the role of [tissue-plasminogen activator (t-PA)] ( Alu-repeat insertion ( I ) /deletion ( D ) ) and plasminogen activator *inhibitor* ( ) ( 4G/5G insertion/deletion ) polymorphisms with MI in the Pakistani population . Negative_regulation PLAT SERPINE1 21199867 2391614 specifically and rapidly *inhibits* uPA and [tissue-type PA (tPA)] . Negative_regulation PLAT SERPINE1 21232303 407682 ACE catalyzes the conversion of angiotensin I to angiotensin II (Ang) , and Ang II stimulates release of , the major *inhibitor* of [tissue-type plasminogen activator (t-PA)] and urokinase in the vasculature . Negative_regulation PLAT SERPINE1 2124638 145397 [ The correlation between the activity of tissue plasminogen activator (TPA) , levels of [tissue plasminogen activator] *inhibitor* ( ) antigen and serum lipids in healthy subjects ] . Negative_regulation PLAT SERPINE1 2124638 145398 In the present study , the correlation between the activity of tissue plasminogen activator (TPA) , the levels of [tissue plasminogen activator] *inhibitor* ( ) and serum lipids ( TC , TG , beta-Lp , HDLC , LDLC and apolipoproteins ) were studied in 102 healthy subjects . Negative_regulation PLAT SERPINE1 21465481 2523650 The activities of uPA/tPA/plasmin and plasmin dependent MMPs rely mostly on the activity of a potent *inhibitor* of [uPA/tPA] , ( PAI-1 ) . Negative_regulation PLAT SERPINE1 21465481 2523790 During wound healing , elevated levels of *inhibit* [uPA/tPA/plasmin] and plasmin dependent MMP activities , and , thus , help expedite wound healing . Negative_regulation PLAT SERPINE1 21998719 2493815 Transfection of an endogenous [tPA] *inhibitor* , ( PAI-1 ) , protected the TTX exposed neurons from dying . Negative_regulation PLAT SERPINE1 22415062 2612576 To explore whether there is a change in plasmin system in CSF of AD patients , we analyzed CSF samples from AD and age matched controls , looking at plasminogen , [tissue plasminogen activator (t-PA)] and plasminogen activator *inhibitor* ( ) protein levels and t-PA and urokinase plasminogen activator (u-PA) enzymatic activities . Negative_regulation PLAT SERPINE1 22573404 2619249 ( PAI-1 ) , an endogenous *inhibitor* of a major fibrinolytic factor , [tissue-type plasminogen activator] , can both promote and inhibit angiogenesis . Negative_regulation PLAT SERPINE1 23199546 2724043 The concentrations of [tissue plasminogen activator] , plasminogen activator *inhibitor* ( ) , tissue factor ( TF ) , TF pathway inhibitor (TFPI) , thrombomodulin , fibrinogen , prothrombin fragment 1+2 and von Willebrand Factor were measured . Negative_regulation PLAT SERPINE1 23521527 2799665 ( PAI-1 ) , the serine protease inhibitor ( serpin ) , binds to and *inhibits* the plasminogen [activators-tissue-type plasminogen activator] ( tPA ) and the urokinase-type plasminogen activator ( uPA ) . Negative_regulation PLAT SERPINE1 24497664 2913755 ( PAI-1 ) , the principal *inhibitor* of [tissue-type plasminogen activator (t-PA)] , has a pronounced circadian rhythm and is elevated in both OSA and cardiovascular disease and may be an important link between the two conditions . Negative_regulation PLAT SERPINE1 2460455 98572 Cyclic AMP potentiates phorbol ester stimulation of [tissue plasminogen activator] release and *inhibits* secretion of from human endothelial cells . Negative_regulation PLAT SERPINE1 2491971 105019 Diurnal variation of [tissue-type plasminogen activator] and its rapid *inhibitor* ( ) . Negative_regulation PLAT SERPINE1 2496627 109666 The following factors were studied in the immediate preoperative period , at different surgical times throughout the procedure and 2-3 h after the end of the abdominal sutures : platelet count , prothrombin concentration , fibrinogen , activated kephalin time , factors II , V , VII + X and VIIIc , antithrombin III , protein C , D-dimers , fibrinogen and fibrin degradation products ( PDF ) , plasma plasminogen , tissue plasminogen activator (tPA) and the fast [tPA] *inhibitor* ( ) . Negative_regulation PLAT SERPINE1 2499321 111900 Corneal epithelial cells secrete [tissue plasminogen activator (t-PA)] , urokinase type plasminogen activator ( u-PA ) and their *inhibitor* ( ) , whereas these cell types in other tissues are known to secrete only u-PA hitherto . Negative_regulation PLAT SERPINE1 2502201 115154 Cultured human umbilical vein endothelial cells release [tissue plasminogen activator (t-PA)] and type 1 plasminogen activator *inhibitor* ( ) in response to alpha thrombin stimulation . Negative_regulation PLAT SERPINE1 2505697 117087 The patients with Behçet 's disease had significantly reduced resting tissue plasminogen activator(t-PA) both by euglobulin fibrin plate lysis and enzyme linked immunosorbent assay ( ELISA ) , but the [tissue plasminogen activator] *inhibitor* ( ) was not significantly different from the control value . Negative_regulation PLAT SERPINE1 2506668 118845 On the other hand , important modifications of fibrinolytic parameters occurred , essentially concerning [tissue-type plasminogen activator (t-PA)] and its specific *inhibitor* ( ) . Negative_regulation PLAT SERPINE1 2514093 123117 ( PAI-1 ) *inhibits* both [tissue-type plasminogen activator] ( tPA ) and urokinase-type plasminogen activator ( uPA ) and , therefore , is an important regulator of plasminogen activation . Negative_regulation PLAT SERPINE1 2514633 123151 von Willebrand factor (VWF) , fibrinogen , [tissue plasminogen activator (t-PA)] and its *inhibitor* ( ) and factor VII . Negative_regulation PLAT SERPINE1 2527002 115336 In order to assess the actual degree of activation of coagulation and fibrinolytic systems in liver disease , plasma levels of thrombin-antithrombin III complex (TAT) and plasmin-alpha 2-antiplasmin complex ( PAP ) were measured together with cross linked fibrin derivatives ( XDP ) , [tissue-type plasminogen activator (t-PA)] , and plasminogen activator *inhibitor* ( ) in 31 patients with liver disease ( five patients with acute hepatitis , seven with chronic hepatitis , nine with liver cirrhosis , and ten with hepatocellular carcinoma ) . Negative_regulation PLAT SERPINE1 2528845 118972 In order to assess the actual degree of activation of the coagulation and fibrinolytic systems in diabetics , plasma levels of thrombin-antithrombin III complex (TAT) and plasmin-alpha 2-plasmin inhibitor complex ( PAP ) were measured together with [tissue-type plasminogen activator (t-PA)] and plasminogen activator *inhibitor* ( ) in 18 patients with DM ( three patients with type I DM and 15 with type II DM ) . Negative_regulation PLAT SERPINE1 2545266 114169 We investigated the effect of agents which raise intracellular levels of cyclic AMP ( cAMP ) on the secretion of [tissue-type plasminogen activator (t-PA)] and type 1 plasminogen activator *inhibitor* ( ) by cultured human umbilical-vein endothelial cells . Negative_regulation PLAT SERPINE1 2781508 119533 Neither fish oil or wheat germ oil caused any significant change in [tissue plasminogen activator (tPA)] or its *inhibitor* ( ) measured enzymatically or in tPA antigen measured by an ELISA method . Negative_regulation PLAT SERPINE1 2814943 121495 In a retrospective study of the 47 patients examined for thrombotic defects , 34 had prolonged euglobulin lysis times ( ELT ) with 27 of these also having elevated [tissue-plasminogen activator] *inhibitor* ( ) activity . Negative_regulation PLAT SERPINE1 2847352 100297 Nor was spontaneous release of [tissue plasminogen activator (t-PA)] or of its *inhibitor* ( ) modified in the presence of patient 's IgG . Negative_regulation PLAT SERPINE1 2847353 100299 No evidence for endothelial release of prostacyclin was obtained as judged from urinary excretion of 2,3-dinor-6-keto-PGF1 alpha ( a major prostacyclin metabolite ) , and plasma concentrations of [tissue plasminogen activator] , its *inhibitor* ( ) and the von Willebrand-factor were unchanged . Negative_regulation PLAT SERPINE1 3128033 91739 To test this hypothesis 12 patients undergoing infrarenal aortic reconstruction due to arteriosclerotic disease were evaluated for influence of the respiratory pattern on release of [tissue plasminogen activator (t-PA)] and its *inhibitor* ( ) in systemic and pulmonary arterial blood . Negative_regulation PLAT SERPINE1 3128548 91787 Functional and immunologic assays indicated that both cytokines decreased HUVEC [tissue-type plasminogen activator] ( tPA ) and increased type 1 plasminogen activator *inhibitor* ( ) in a dose- and time dependent manner . Negative_regulation PLAT SERPINE1 3133814 94282 Daytime fluctuations in blood of [tissue-type plasminogen activator (t-PA)] and its fast acting *inhibitor* ( ) . Negative_regulation PLAT SERPINE1 3146134 102042 In this study , the importance of anthropometric , nutritional and endocrine variables on the plasma concentrations of [tissue plasminogen activator] antigen ( tPA ) and plasminogen activator *inhibitor* ( ) were investigated . Negative_regulation PLAT SERPINE1 3148526 103470 Cultured endothelial cells ( ECs ) produce type 1 ( PAI-1 ) , the physiologic *inhibitor* of [tissue-type plasminogen activator] . Negative_regulation PLAT SERPINE1 3262512 97849 *inhibits* both [tissue-type plasminogen activator] and urokinase-type plasminogen activator and may therefore be implicated in the control of various physiological processes . Negative_regulation PLAT SERPINE1 7474443 331498 Changes in PIC , [tissue-type plasminogen activator] , and plasminogen activator inhibitor-1 ( PAI-1 ) in the clinical course of case 1 suggested that fibrinolysis was *suppressed* by relatively elevated level of around the operation , but thereafter was adversely accelerated by relatively lower levels of PAI-1 . Negative_regulation PLAT SERPINE1 7474459 322851 To determine the effects of interferon ( IFN ) treatment for chronic hepatitis C on vascular endothelium , we measured the concentrations of [tissue plasminogen activator (t-PA)] and its *inhibitor* ( ) in the plasma from patients before and after IFN treatment for 14 consecutive days . Negative_regulation PLAT SERPINE1 7517736 243630 On the other hand , as for uPA , [tPA] is *inhibited* by . Negative_regulation PLAT SERPINE1 7586269 333749 Experimental measurements of cardiac output , heart rate , [tissue plasminogen activator (TPA)] , urokinase plasminogen activator (UPA) , plasminogen activator *inhibitor* ( ) , C1-inhibitor , and TPA/C1-inhibitor complex during the infusions and exercise were used to develop a comprehensive fluid-phase model of the circulatory regulation of fibrinolysis . Negative_regulation PLAT SERPINE1 7738206 305673 ( PAI-1 ) , the primary *inhibitor* of [tissue-type plasminogen activator (t-PA)] and urokinase plasminogen activator , is an important regulator of the blood fibrinolytic system . Negative_regulation PLAT SERPINE1 7897822 289900 Plasma levels of beta thromboglobulin (BTG) , platelet factor-4 (PF4) , [tissue plasminogen activator (t-PA)] , plasminogen activator *inhibitor* ( ) and plasminogen were determined in 36 essential hypertensive and 20 age and sex matched control subjects . Negative_regulation PLAT SERPINE1 7924883 273328 To determine whether previously reported abnormalities in fibrinolytic activity and plasma lipoprotein (a) levels could reflect obesity rather than diabetes per se , plasma concentrations of [tissue-type plasminogen activator (t-PA)] , type 1 plasminogen activator *inhibitor* ( ) , and lipoprotein (a) ( Lp (a) ) were investigated in sixty-four type 2 diabetic patients ( 56.1 +/- 9.5 years ; body mass index , 24.6 +/- 3.3 kg/m2 ) and thirty-two control subjects ( 57.9 +/- 8.9 years ; body mass index , 24.6 +/- 3.4 kg/m2 ) . Negative_regulation PLAT SERPINE1 7985828 282308 The antigen levels of von Willebrand factor (vWF) , [tissue plasminogen activator (t-PA)] , and its *inhibitor* ( ) were also determined as markers of release from the endothelium , while the fragment 1 + 2 of prothrombin (F1 + 2) and thrombin-antithrombin III (TAT) complexes were assessed as indexes of systemic thrombin generation . Negative_regulation PLAT SERPINE1 8018108 262689 The impact of long-term , heavy exercise on recently established cardiovascular/thromboembolic risk factors of the fibrinolytic system , [tissue plasminogen activator (tPA)] and plasminogen activator *inhibitor* ( ) in relation to food composition was studied . Negative_regulation PLAT SERPINE1 8034724 264569 ( PAI-1 ) , the main physiological *inhibitor* of [tissue-type plasminogen activator (t-PA)] , may occur in three interconvertible conformations : active , latent , and substrate . Negative_regulation PLAT SERPINE1 8044939 266868 To determine if the failure to lyse pulmonary thromboemboli is caused by an abnormality in the endothelial cell ( EC ) -associated fibrinolytic system , conditions were established to culture ECs from patient main pulmonary arteries during surgical pulmonary thromboendarterectomies and to analyze the conditioned media for levels of [tissue-type plasminogen activator (TPA)] and type 1 plasminogen activator *inhibitor* ( ) . Negative_regulation PLAT SERPINE1 8052177 267745 We investigated [tissue plasminogen activator (tPA)] , its main *inhibitor* ( ) and the natural anticoagulants protein C and S by enzymimmunoassay prospectively in 32 bone marrow transplant recipients . Negative_regulation PLAT SERPINE1 8111706 246211 In this study , we measured the antigen levels of urokinase ( u-PA ) , [tissue plasminogen activator (t-PA)] , type 1 plasminogen activator *inhibitor* ( ) , and type 2 plasminogen activator inhibitor ( PAI-2 ) , and cancer tissue ( 19 adenocarcinomas and 19 squamous cell carcinomas ) and normal lung tissue . Negative_regulation PLAT SERPINE1 8126014 242044 The aim of this study was the evaluation of the in vitro production of prostacyclin , and of [tissue plasminogen activator (tPA)] and its *inhibitor* , , by human endothelial cells cultured in the presence of polyethylene terephthalate (PET) . Negative_regulation PLAT SERPINE1 8134903 242121 We compared the plasma TM levels with the plasma levels of other specific markers of endothelial cell activation such as : prostacyclin ( PGI2 ) , [tissue-type plasminogen activator (t-PA)] and plasminogen activator *inhibitor* ( ) . Negative_regulation PLAT SERPINE1 8165630 254821 Platelets contain a great deal of ( PAI-1 ) , the principal endogenous *inhibitor* of [tissue-type plasminogen activator (t-PA)] . Negative_regulation PLAT SERPINE1 8204808 261126 There were decreases in AT , factors V , II , X , IX , protein S ( total and free ) , C4b binding protein , thrombomodulin , and platelets counts , whereas heparin , ACT , thrombospondin , plasminogen activator *inhibitor* ( ) , and [tissue plasminogen activator (tPA)] increased . Negative_regulation PLAT SERPINE1 8264050 239270 The balance between the EC-derived fibrinolytic components , plasminogen activator ( [tPA] ) , and plasminogen *inhibitor* ( ) contributes to maintaining thromboresistance . Negative_regulation PLAT SERPINE1 8330376 223564 Transferable lipids in oxidized low-density lipoprotein stimulate and *inhibit* [tissue-type plasminogen activator] release from endothelial cells . Negative_regulation PLAT SERPINE1 8400098 230716 To evaluate the drug 's influence on the coagulation and fibrinolytic systems , von Willebrand factor (vWF) , the activities of [tissue plasminogen activator (tPA)] and plasminogen activator *inhibitor* ( ) , and the split products of cross linked fibrin ( D-dimers ) were investigated . Negative_regulation PLAT SERPINE1 8418375 210485 Despite normal or high [tissue plasminogen activator (tPA)] and plasminogen activator *inhibitor* ( ) antigen levels , the plasma PAI-1 activity and the formation of tPA/PAI-1 complexes were lower in APL patients than in normal controls , suggesting a proteolytic degradation of PAI-1 , not able to complex tPA . Negative_regulation PLAT SERPINE1 8504511 221276 In four normotensive subjects and six hypertensive patients , we investigated whether infusion of angiotensin II (Ang II) affected circulating levels of ( PAI-1 ) , the most important physiological *inhibitor* of [tissue-type plasminogen activator (t-PA)] . Negative_regulation PLAT SERPINE1 8584993 331360 Plasma samples were drawn from 212 out-patients treated with oral anticoagulants , at the beginning of the study , and analyzed for mass concentration of [tissue plasminogen activator (tPA)] and its *inhibitor* ( ) , and von Willebrand factor . Negative_regulation PLAT SERPINE1 8614068 353593 Serial blood samples were obtained via femoral venous catheters for tissue plasminogen activator (tPA) , plasminogen activator *inhibitor* ( ) , [tPA-PAI-1] complex ( tPA-PAI ) , and euglobulin lysis time ( ELT ) from all subjects and for fibrin degradation products ( FbDP ) and fibrinogen degradation products (FgDP) from phase II subjects . Negative_regulation PLAT SERPINE1 8639841 362575 ( PAI-1 ) , a rapid *inhibitor* of both uPA and [tissue-type plasminogen activator] ( tPA ) is the major physiologic regulator of plasminogen activator activity . Negative_regulation PLAT SERPINE1 8679836 365823 We obtained that the fibrinogen , [tissue plasminogen activator (tPA)] and plasminogen activator *inhibitor* ( ) levels are significantly increased ( p < 0.01 ) in the group of patients , and in the same way , there are also differences ( p < 0.01 ) between men and women , so in the control group as in the patients group ; Negative_regulation PLAT SERPINE1 8681360 365825 [ Levels of [tissue-type plasminogen activator (T-PA)] , its *inhibitor* ( ) and fibrinogen in the blood of patients with type 1 and 2 diabetes mellitus ] . Negative_regulation PLAT SERPINE1 8703831 373346 Sequential analyses in a control group with active PTB showed anaemia , thrombocytosis , elevations in plasma fibrinogen , fibrin(ogen) degradation products ( FDP ) , [tissue plasminogen activator (t-PA)] and *inhibitor* ( ) with depressed antithrombin III levels . Negative_regulation PLAT SERPINE1 8725727 376749 Production of [tissue-type plasminogen activator (t-PA)] and type-1 plasminogen activator *inhibitor* ( ) in mildly cirrhotic rat liver . Negative_regulation PLAT SERPINE1 8725727 376751 We have studied the production of [tissue-type plasminogen activator (t-PA)] and type-1 plasminogen activator *inhibitor* ( ) in liver of normal rats and in rats with mild cirrhosis induced by carbon tetrachloride inhalation , to demonstrate the production of these fibrinolytic components and their pathophysiologic role in the liver in vivo . Negative_regulation PLAT SERPINE1 8815589 366044 Though the secreted antigens for [tissue-type plasminogen activator (t-PA)] and type 1 plasminogen activator *inhibitor* ( ) in the conditioned medium ( CM ) of HUVECs were simultaneously increased at 43 degrees C during this period , the increase in the levels of t-PA ( about 26.6-fold at 120 min ) was greater than that of PAI-1 ( 1.8-fold at 120 min ) . Negative_regulation PLAT SERPINE1 8830927 385641 This review focuses on the main components of the fibrinolytic system -- [tissue plasminogen activator (tPA)] , urokinase ( uPA ) and plasminogen activator *inhibitor* ( ) -- and on thrombin . Negative_regulation PLAT SERPINE1 8838483 386582 Additionally , [tissue plasminogen activator (t-PA)] and plasminogen activator *inhibitor* ( ) were measured before and after venous occlusion and delta and ratio values calculated . Negative_regulation PLAT SERPINE1 8854251 388066 Using mice with inactivated [tissue PA (tPA)] , urokinase PA (uPA) , or type 1 PA *inhibitor* ( ) genes , we evaluated whether these processes , or their stimulation by parathyroid hormone (PTH) or 1,25-dihydroxyvitamin ( 1,25 [ OH ] 2D3 ) are dependent on these genes . Negative_regulation PLAT SERPINE1 8864251 388955 NO metabolites ( NO2- and NO3- ) , endothelin ( ET-1 ) , [tissue plasminogen activator (tPA)] , plasminogen activator *inhibitor* ( ) , fibrinogen , D-dimer , fibrinopeptide A , beta thromboglobulin ( beta-TG ) , blood viscosity , plasma viscosity , haematocrit (Htc) and red blood cell ( RBC ) filterability index ( FI ) were determined during headache free periods . Negative_regulation PLAT SERPINE1 8869368 344902 on the plasma of each sample the determination of fibrinogen (F) ( coagulative method ) , [tissue plasminogen activator (t-PA)] , plasminogen activator *inhibitor* ( ) , D-dimer ( D-D ) , fibrinopeptide A ( FPA ) and betathromboglobulin (BTG) ( ELISA methods ) was performed . Negative_regulation PLAT SERPINE1 8888658 391619 Hormone replacement therapy in postmenopausal women has been shown to enhance fibrinolytic capacity by lowering plasminogen activator inhibitor-1 ( ) and [tissue plasminogen activator] *inhibitor* ( tPA ) antigen values . Negative_regulation PLAT SERPINE1 8891455 391951 This study attempted to verify the existence of a relationship between oxidative stress documented by malondialdehyde ( MDA ) and superoxide dismutase (SOD) and fibrinolysis analysed by [tissue plasminogen activator (tPA)] and its *inhibitor* ( ) in diabetes mellitus . Negative_regulation PLAT SERPINE1 8894659 392407 Alterations in the plasma levels of [tissue plasminogen activator (t-PA)] and plasminogen activator *inhibitor* ( ) as observed in various liver disorders are attributed to deranged liver function . Negative_regulation PLAT SERPINE1 8965977 398129 [[Tissue plasminogen activator] ( T-PA ) and tissue plasminogen activator *inhibitor* ( ) in patients after head injury ] . Negative_regulation PLAT SERPINE1 8974793 389347 Coagulation was explored by standard clotting tests and by measurement of prothrombin complex factors , factor VIII ( VIII : C ) and antithrombin III (ATIII) , protein C ( PC ) and protein S ( PS ) activities , while fibrinolytic potential was evaluated using D-dimer , [tissue plasminogen activator (t-PA)] and plasminogen activator *inhibitor* ( ) assays . Negative_regulation PLAT SERPINE1 9019590 404924 [ Post-mortem concentration of [tissue plasminogen activator (t-PA)] and plasminogen activator *inhibitor* ( ) in the vitreous body of the human eye ] . Negative_regulation PLAT SERPINE1 9030577 414580 ( PAI-1 ) , the primary *inhibitor* of [tissue-type plasminogen activator] and urokinase , is known to convert readily to a latent form by insertion of the reactive center loop into a central beta-sheet . Negative_regulation PLAT SERPINE1 9058494 417641 Levels of prothrombin fragments 1 + 2 , D-dimers , plasminogen , alpha 2-antiplasmin , [tissue plasminogen activator (tPA)] , and plasminogen activator *inhibitor* ( ) in venous blood were investigated just before the operation , at the end of the operation and three hours later . Negative_regulation PLAT SERPINE1 9062954 418027 ( PAI-1 ) , the major physiologic *inhibitor* of [tissue-type plasminogen activator] and urokinase , is abundantly expressed in atherosclerotic vascular wall . Negative_regulation PLAT SERPINE1 9097084 422632 In the patients and in 10 control subjects , plasma levels of thrombomodulin , beta-thromboglobulin , D-dimer , [tissue-type plasminogen activator (t-PA)] and plasminogen activator *inhibitor* ( ) had previously been measured . Negative_regulation PLAT SERPINE1 9175322 433580 Citrated blood samples were taken from each patient the day before surgery and on postoperative days 1 , 3 , and 7 , before and after venous occlusion , in order to evaluate plasma levels of [tissue plasminogen activator (t-PA)] and plasminogen activator *inhibitor* ( ) . Negative_regulation PLAT SERPINE1 9184262 436656 Imbalance of [tissue-type plasminogen activator (t-PA)] and its specific *inhibitor* ( ) in patients with rheumatoid arthritis associated with disease activity . Negative_regulation PLAT SERPINE1 9186598 436872 The plasminogen system , via its triggers , [tissue-type plasminogen activator (t-PA)] and urokinase-type plasminogen activator ( u-PA ) and its *inhibitor* , ( PAI-1 ) , has been implicated in thrombosis , arterial neointima formation , and atherosclerosis . Negative_regulation PLAT SERPINE1 9296893 451257 The aim of study was the evaluation of [tissue plasminogen activator (t-PA)] and its *inhibitor* ( ) in the II type diabetes on the base of the common fibrinolytic system tests as euglobulin lysis time ( ELT ) and the concentration of fibrin/fibrinogen products ( FDP ) . Negative_regulation PLAT SERPINE1 9345281 459352 Induction of [tissue-type plasminogen activator] ( tPA ) and type-1 plasminogen activator *inhibitor* ( ) as early growth responses in rat hepatocytes in primary culture . Negative_regulation PLAT SERPINE1 9345281 459354 Early growth response with respect to [tissue-type plasminogen activator] ( tPA ) and type-1 plasminogen activator *inhibitor* ( ) gene expression was studied in rat hepatocytes in primary culture . Negative_regulation PLAT SERPINE1 9374919 465328 Patients had higher mean levels of [tPA] *inhibitor* ( ) than controls ( P < 0.001 ) , levels being more elevated amongst patients with diffuse than limited disease ( P = 0.01 ) . Negative_regulation PLAT SERPINE1 9562609 500603 Regulation of [tissue-type plasminogen activator] ( tPA ) and type-1 plasminogen activator *inhibitor* ( ) gene expression in rat hepatocytes in primary culture . Negative_regulation PLAT SERPINE1 9627033 511991 [Tissue-type plasminogen activator] ( tPA ) and its *inhibitor* ( ) in patients treated with continuous ambulatory peritoneal dialysis . Negative_regulation PLAT SERPINE1 9627033 511992 To establish whether the values of two key enzymes of fibrinolysis , [tissue-type plasminogen activator] ( tPA ) and its *inhibitor* ( ) , differ between patients treated with continuous ambulatory peritoneal dialysis ( CAPD ) and healthy volunteers and whether plasma and dialysate tPA and PAI-1 values vary during one exchange of dialysis solution . Negative_regulation PLAT SERPINE1 9676025 520367 Samples were taken before , at 3 and 9 months after the beginning of the program to measure : [tissue-type plasminogen activator (t-PA)] antigen and plasminogen activator *inhibitor* ( ) activity and antigen . Negative_regulation PLAT SERPINE1 9702473 525386 [Tissue-type plasminogen activator (t-PA)] and plasminogen activator *inhibitor* ( ) were studied in 18 smokers and 18 closely matched non-smokers , all of whom had Type 1 diabetes mellitus ( DM ) . Negative_regulation PLAT SERPINE1 9710719 526966 [Tissue plasminogen activator (T-PA)] and plasminogen activator *inhibitor* ( ) levels in the conditioned medium of cultured porcine brain microvascular endothelial cells . Negative_regulation PLAT SERPINE1 9812085 545975 Biologic variables analyzed included apolipoprotein B (apo B) , lipoprotein (a) , C-reactive protein (CRP) , fibrinogen , factor VII , [tissue plasminogen activator (TPA)] and *inhibitor* ( ) , thrombin-antithrombin (TAT) , fragment 1+2 (F1+2) , von Willebrand factor (vWF) , activated protein C resistance , homocyst ( e ) ine , anticardiolipin antibodies , blood group , and the angiotensin converting enzyme insertion/deletion ( I/D ) and angiotensin II receptor gene polymorphisms . Negative_regulation PLAT SERPINE1 9842006 552972 Plasma levels of modified antithrombin III (ATM) , [tissue plasminogen activator (TPA)] , its *inhibitor* ( ) , TPA-PAI-1 complexes and plasmin-antiplasmin complexes (PAP) , d -dimer , and fibrinogen were measured in plasma from 36 patients with chronic atrial fibrillation . Negative_regulation PLAT SERPINE1 9893018 558636 Changes in [tissue plasminogen activator (t-PA)] and plasminogen activator *inhibitor* ( ) , another two endothelium derived proteins and modulators of blood fibrinolytic activity , have not been reported in hyperthyroidism . Negative_regulation PLAT SERPINE1 9926277 559377 The aim of this study was to evaluate the effect of a new antihypertensive agent , moxonidine ( M ) , on microalbuminuria ( urine albumin excretion , UAE ) , plasma thrombomodulin (TM) , and [tissue plasminogen activator] *inhibitor* ( ) in patients with mild to moderate EH associated with increased UAE . Negative_regulation PLAT SERPINF2 2929007 109286 Treatment with both glutathione depleting agents *induced* a significant reduction in the functional activity of [tissue plasminogen activator (t-PA)] ( -61 % and -27 % respectively for buthionine sulphoximine or diethyl maleate ) and a significant increase in that of plasminogen activator-inhibitor (PAI) ( +61 % and +27 % respectively ) , while activity was not modified . Negative_regulation PLAT SERPINF2 8836361 386259 To evaluate the ability of commercial , chromogenic kits designed to measure human fibrinolytic pathway components to measure the canine plasma fibrinolytic pathway enzymes , [tissue plasminogen activator (tPA)] and plasminogen (PLG) , and their respective *inhibitors* , plasminogen activator inhibitor 1 (PAI) and . Negative_regulation PLAT SERPINI1 10642518 660943 As *inhibits* [tissue plasminogen activator (tPA)] in vitro , we measured plasminogen-activator levels . Negative_regulation PLAT SERPINI1 12070304 955795 Specifically , seizure induction by KA injection into the amygdala induces tPA activity and cell death in both hippocampi , and unilateral treatment of rats with , a natural *inhibitor* of [tPA] in the brain , enhances neuronal survival in both hippocampi . Negative_regulation PLAT SERPINI1 12163437 972375 We tested the hypothesis that , a natural *inhibitor* of [tPA] , reduces tPA induced neuronal toxicity and increases its therapeutic window for treatment of embolic stroke . Negative_regulation PLAT SERPINI1 12805124 1101568 Analysis of tissue samples on reducing and non reducing polyacrylamide gels demonstrates complexes of tPA with plasminogen activator inhibitor-1 ( PAI-1 ) but not with , a [tPA-specific] *inhibitor* concentrated in grey matter . Negative_regulation PLAT SERPINI1 16209928 1489127 The brain-specific [tissue-type plasminogen activator] *inhibitor* , , protects neurons against excitotoxicity both in vitro and in vivo . Negative_regulation PLAT SERPINI1 16209928 1489128 Considering its brain-specific expression , , a potent *inhibitor* of [tissue-type plasminogen activator] ( tPA ) , might be a good therapeutic target to limit the pro-excitotoxic effects of tPA within the cerebral parenchyma , without affecting the benefit from thrombolysis in stroke patients . Negative_regulation PLAT SERPINI1 19222708 2050254 Thus , *inhibition* of [tissue plasminogen activator] activity leads to reduced plasmin and may be responsible for reduced clearance of amyloid-beta in the Alzheimer disease brain . Negative_regulation PLAT SERPINI1 20864675 2343003 In vitro studies show that *inhibits* [tPA] and , to a lesser extent , urokinase-type plasminogen activator and plasmin . Negative_regulation PLAT SERPINI1 21163314 2390729 , a natural *inhibitor* of [tPA] , has shown neuroprotective effects in animal models of brain infarct . Negative_regulation PLAT SERPINI1 21689108 2465446 These results support the concept that *inhibition* of [tissue plasminogen activator] plays an important role both in the accumulation of brain amyloid plaques and loss of cognitive abilities . Negative_regulation PLAT SERPINI1 22742704 2644377 Expression of , a selective *inhibitor* of [tissue-type plasminogen activator] in the human skin . Negative_regulation PLAT SERPINI1 23658802 2784770 , an endogenous *inhibitor* of [tPA] , is up-regulated following cerebral ischemia . Negative_regulation PLAT SERPINI1 9364046 462972 Expression of , an *inhibitor* of [tissue plasminogen activator] , in the developing and adult nervous system of the mouse . Negative_regulation PLAT SERPINI1 9364046 462976 In vitro , formed SDS-stable complexes and *inhibited* the amidolytic activity of [tissue plasminogen activator] , urokinase , and plasmin . Negative_regulation PLAT SPINK1 2461702 100203 The ability of to *inhibit* trypsin , plasmin , urokinase and [tPA] suggests that it has a role in proteolytic processes in vivo involving these enzymes . Negative_regulation PLAT STX2 24578379 2929540 Our functional studies implicate a novel *role* for STXBP5 and in regulating [tPA] release . Negative_regulation PLAT STXBP5 24578379 2929539 Our functional studies implicate a novel *role* for and STX2 in regulating [tPA] release . Negative_regulation PLAT TAT 11929177 927231 We measured plasma levels of , fibrinopeptide A ( FPA ) , tissue plasminogen activator-plasminogen activator *inhibitor* ( [tPA-PAI] ) : markers of coagulation-fibrinolysis-system , and also beta-thromboglobulin ( beta-TG ) : a marker of platelet activation , in 40 COPD patients and in 20 control subjects . Negative_regulation PLAT TGFB1 14597403 1160620 In contrast , *triggered* a large decrease of uPA and [tPA] , as well as a decrease of uPA and uPAR mRNAs . Negative_regulation PLAT TIMP1 10536373 562893 We measured extracellular matrix metalloproteinases ( MMPs ) , [tissue plasminogen activator (tPA)] , tissue *inhibitor* of metalloproteinase ( ) , and collagen I expression in VSMC by specific substrate zymography and Northern blot analyses . Negative_regulation PLAT TNF 15207722 1261664 RT-PCR analysis and gene reporter assays using the human tPA promoter indicated that upregulation of the tPA gene transcription by both Neovastat and was correlated with the phosphorylation of JNK1/2 and of IkappaB and that SP600125 and BAY11-7082 , inhibitors of JNK and IkappaK , respectively , *inhibit* the increase of [tPA] gene transcription induced by Neovastat and TNFalpha . Negative_regulation PLAT TNF 16879221 1593898 *mediated* suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 MAPK dependent . Negative_regulation PLAT TNF 1995504 154275 At the endothelial level down-regulates thrombomodulin ( thus preventing protein C formation ) and *inhibits* the production of [tissue plasminogen activator (t-PA)] , thus impairing anticoagulant mechanisms . Negative_regulation PLAT VTN 1693270 132745 Moreover , was found to *inhibit* in a dose dependent fashion the fibrin(ogen) induced activation of plasminogen by [tissue plasminogen activator] . Negative_regulation PLAT VWF 1653670 164676 3. Venous blood samples were taken before , during and after the procedure for assay of plasma vasopressin , adrenaline and noradrenaline concentrations , Factor VIII coagulant activity , antigen level , euglobulin clot lysis time , tissue-type plasminogen activator activity and [tissue-type plasminogen activator] *inhibition* . Negative_regulation PLAT VWF 3070826 103390 Template bleeding time , activity ( ristocetin co-factor ) and antigen , euglobulin lysis time and type I [tissue plasminogen activator] *inhibitor* were determined before and at the end of each treatment period . Negative_regulation PLAU ADCYAP1 11870092 918409 The use of cycloheximide , a protein synthesis inhibitor , suggested that *requires* an intermediary protein to decrease [uPA-mRNA] , but not to induce tPA-mRNA . Negative_regulation PLAU ALB 9249034 446556 This activity of the [pro-uPA/uPAR-] ( 1-281 ) -peptide complex but not that of tc-uPA was completely *inhibited* by human , bovine serum albumin , Tween-80 , Triton X-100 , and Pluronic-F68 . Negative_regulation PLAU AP1B1 15558021 1361113 Upregulation of JunB expression in MEKK1-/- cells forms an inhibitory that binds to the uPA promoter and *inhibits* [uPA] transcription . Negative_regulation PLAU AP1G1 15558021 1361114 Upregulation of JunB expression in MEKK1-/- cells forms an inhibitory that binds to the uPA promoter and *inhibits* [uPA] transcription . Negative_regulation PLAU ASGR1 12152683 971407 In order to study the *role* of the in the rapid plasma clearance of [urokinase-type plasminogen activator] ( u-PA ) , a microtiter plate binding assay was developed using ASGPr purified from rat liver extracts . Negative_regulation PLAU ASGR2 12152683 971408 In order to study the *role* of the in the rapid plasma clearance of [urokinase-type plasminogen activator] ( u-PA ) , a microtiter plate binding assay was developed using ASGPr purified from rat liver extracts . Negative_regulation PLAU ASPRV1 17359337 1712597 significantly *inhibited* VEGF induced proteolytic enzyme production , including matrix metalloproteinase-2 , [urokinase-type plasminogen activator] and plasminogen activator inhibitor-1 . Negative_regulation PLAU BCL10 23392805 2739933 Overexpression of TRAF2 or strongly *increased* TRAIL mediated upregulation of [uPA] and IL-8 . Negative_regulation PLAU BCL2 23392805 2739934 Overexpression of TRAF2 or strongly *increased* TRAIL mediated upregulation of [uPA] and IL-8 . Negative_regulation PLAU BCL3 23392805 2739935 Overexpression of TRAF2 or strongly *increased* TRAIL mediated upregulation of [uPA] and IL-8 . Negative_regulation PLAU BCL5 23392805 2739929 Overexpression of TRAF2 or strongly *increased* TRAIL mediated upregulation of [uPA] and IL-8 . Negative_regulation PLAU BCL6 23392805 2739930 Overexpression of TRAF2 or strongly *increased* TRAIL mediated upregulation of [uPA] and IL-8 . Negative_regulation PLAU BCL9 23392805 2739931 Overexpression of TRAF2 or strongly *increased* TRAIL mediated upregulation of [uPA] and IL-8 . Negative_regulation PLAU BMP2 16475709 1524132 Gel zymography for matrix metalloproteinases ( MMPs ) and urokinase-type plasminogen activator ( uPA ) detection revealed that *down-regulated* the activity of MMP-9 , but not of MMP-2 or [uPA] . Negative_regulation PLAU BMP4 17275810 1704341 Overexpression of changed cell morphology to invasive spindle phenotype and *induced* the expression and activity of [urokinase plasminogen activator (uPA)] . Negative_regulation PLAU BSG 17210677 1681415 Additionally , overexpression of in NS2T2A cells *increased* [uPA] levels in cocultured endothelial cells , showing a paracrine regulation loop involving a tumor-stroma interaction . Negative_regulation PLAU CALCA 1796756 176340 Although inhibiting bone resorption , had no effect on the PTH induced accumulation of PA in bone or on the release of tPA , but it *prevented* the PTH induced accumulation of 29 kD [uPA] in the culture fluids . Negative_regulation PLAU CAMP 20624254 2297085 Serum and induced sputum levels of urokinase-type plasminogen activator ( uPA ) , urokinase-type plasminogen activator receptor ( uPAR ) , [urokinase-type plasminogen activator] *inhibitor* ( PAI-1 ) and human cationic antimicrobial protein 18 ( ) were measured by ELISA , in 13 patients with stage I or stage II COPD ( COPD I + II ) , 15 patients with stage III or stage IV COPD ( COPD III + IV ) , 18 healthy non-smokers and 14 healthy smokers . Negative_regulation PLAU CAV1 22140072 2557867 We also sought to determine whether scaffolding domain peptide ( CSP ) reverses these changes to protect against ALI and PF. Tissues as well as isolated ATII cells from the lungs of wild-type ( WT ) mice with BLM injury show *increased* apoptosis , p53 , and PAI-1 , and reciprocal suppression of [uPA] and uPA receptor (uPAR) protein expression . Negative_regulation PLAU CTSB 11815600 928871 [Pro-uPA] activation was preceded by dramatic changes in lysosome trafficking and the extracellular appearance of and beta-hexosaminidase but not cathepsins D or L. Co-treatment of cultures with the cathepsin B inhibitors CA-074 or Z-FA-FMK *suppressed* the cytostatic effects of TPA and activation of pro-uPA . Negative_regulation PLAU CTSB 17172424 1662299 RNA interference mediated simultaneous down-regulation of [urokinase-type plasminogen activator] receptor and *induces* caspase-8 mediated apoptosis in SNB19 human glioma cells . Negative_regulation PLAU CTSB 1900515 153993 efficiently *activates* the soluble and the tumor cell receptor bound form of the proenzyme [urokinase-type plasminogen activator] ( Pro-uPA ) . Negative_regulation PLAU DNMT1 15618232 1375571 We tested the hypothesis that up-regulation of will *lead* to methylation and silencing of [uPA] and inhibition of the invasiveness of metastatic breast cancer cells . Negative_regulation PLAU E2F1 10688648 670076 Interestingly , an mutant lacking the pRB binding region strongly *repressed* the [uPA] and PAI-1 promoters . Negative_regulation PLAU EDN1 11719468 883698 In addition , *induced* overexpression of [urokinase-type plasminogen activator] , its receptor , and plasminogen activator inhibitor type-1 and -2 . Negative_regulation PLAU EGF 21303946 2403657 *dependent* induction of matrix metalloproteinase (MMP)-2 , pro- and active form of [urokinase plasminogen activator] , and chorionic gonadotropin ( CG ) -ß was noticed in shRNAmir-control cells , whereas these genes were suppressed in EGF treated shRNAmir-AP-2a cells . Negative_regulation PLAU EGR1 21283769 2387877 In addition , forced expression of *promoted* down-regulation of [urokinase plasminogen activator] , urokinase receptor , and urokinase plasminogen activity . Negative_regulation PLAU ELAVL1 14517288 1147349 These results indicate a *role* for and MK2 in regulating the expression of [uPA] and uPAR genes at the posttranscriptional level . Negative_regulation PLAU EPHB2 17264880 1691416 Inhibiting and JNK pathways significantly *reduced* PAI and [uPA] induction and inhibited the invasive cell phenotype . Negative_regulation PLAU EPHB2 20491781 2288868 Both and JNK inhibitors significantly *inhibited* hypoxia induced expression of 67LR and the subsequent expression of [uPA] and MMP 9 . Negative_regulation PLAU ERVK-6 19472211 2102228 We further demonstrate that another [uPA] *inhibitor* , , also stimulates cell detachment in a uPA/uPAR dependent manner . Negative_regulation PLAU ETS1 18772901 2020435 In addition , expression of the in the pancreatic cancer cells *resulted* in downregulation of [urokinase-type plasminogen activator] ( u-PA ) and metalloproteinase-1 ( MMP-1 ) expression . Negative_regulation PLAU FERMT2 18505917 1917950 Consistent with a suppressive role in mesenchymal cancer cell invasion , *inhibits* [urokinase-type plasminogen activator] ( uPA ) secretion and pericellular proteolysis . Negative_regulation PLAU FERMT2 18505917 1917951 Overexpression of *increased* [uPA] accumulation at the intracellular face of cell-ECM adhesions and reduced the level of secreted uPA . Negative_regulation PLAU FGF1 8868466 389204 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Negative_regulation PLAU FGF10 8868466 389205 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Negative_regulation PLAU FGF11 8868466 389206 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Negative_regulation PLAU FGF12 8868466 389207 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Negative_regulation PLAU FGF13 8868466 389208 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Negative_regulation PLAU FGF14 8868466 389209 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Negative_regulation PLAU FGF16 8868466 389210 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Negative_regulation PLAU FGF17 8868466 389211 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Negative_regulation PLAU FGF18 8868466 389212 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Negative_regulation PLAU FGF19 8868466 389213 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Negative_regulation PLAU FGF2 10892857 711305 Both IL-1beta and TNF-alpha *induced* a significant decrease in [uPA] expression in PBF , whereas induced a slight increase in both HJF and PBF . Negative_regulation PLAU FGF2 8868466 389214 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Negative_regulation PLAU FGF2 8868466 389271 The results show that FGF-2 antagonists suramin , protamine , heparin , the synthetic peptide ( 112-155 ) , and a soluble form of FGFR-1 do not *inhibit* FGF-2 mediated [uPA] up-regulation at concentrations that affect growth factor binding to cell surface receptors and mitogenic activity . Negative_regulation PLAU FGF2 9314544 455526 Stimulation of EC with *resulted* in increased expression of Hox D3 , integrin alphavbeta3 , and the [urokinase plasminogen activator (uPA)] . Negative_regulation PLAU FGF2 9442043 483070 , but not serum , *repressed* [uPA] expression in differentiation committed myoblasts , and these effects were also shown to occur at the level of uPA transcription . Negative_regulation PLAU FGF20 8868466 389215 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Negative_regulation PLAU FGF21 8868466 389216 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Negative_regulation PLAU FGF22 8868466 389217 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Negative_regulation PLAU FGF23 8868466 389218 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Negative_regulation PLAU FGF3 8868466 389219 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Negative_regulation PLAU FGF4 8868466 389220 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Negative_regulation PLAU FGF5 8868466 389221 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Negative_regulation PLAU FGF6 8868466 389222 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Negative_regulation PLAU FGF7 8868466 389223 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Negative_regulation PLAU FGF8 8868466 389224 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Negative_regulation PLAU FGF9 8868466 389225 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Negative_regulation PLAU FGFR1 8868466 389272 The results show that FGF-2 antagonists suramin , protamine , heparin , the synthetic peptide FGF-2 ( 112-155 ) , and a soluble form of do not *inhibit* FGF-2 mediated [uPA] up-regulation at concentrations that affect growth factor binding to cell surface receptors and mitogenic activity . Negative_regulation PLAU FOXP3 19628330 2195004 Moreover , up-regulation of *reduced* the expression of matrix metalloproteinase-2 (MMP-2) and [urokinase-type plasminogen activator] ( uPA ) , resulting in the inhibition of cell migration and invasion . Negative_regulation PLAU GDF15 12907645 1119267 The overexpression of into SNU-216 cells significantly *increased* the activity of [urokinase-type plasminogen activator] ( uPA ) , and the expressions of uPA and urokinase-type plasminogen activator receptor ( uPAR ) . Negative_regulation PLAU GJB1 16289236 1532324 These results suggest that might *reduce* PAI-1 , [uPA] and uPAR production in metastatic RCC cells via the inhibition of Src dependent induction of HIF-1alpha and HIF-2alpha gene expression and that Cx32 might suppress hypoxia-inducible gene expression under hypoxic conditions . Negative_regulation PLAU GLA 7739415 288915 Oxidation of LA by lipoxidase especially increases tumour cell death , whilst *inhibits* [urokinase-type plasminogen activator] ( uPA ) activity . Negative_regulation PLAU GRB2 9038378 415566 Regulation of the [urokinase-type plasminogen activator] gene by the oncogene Tpr-Met *involves* . Negative_regulation PLAU HDAC1 12198113 997927 The inhibitor , Trichostatin A , *induces* the expression of the [uPA] gene in MDA-MB-231 cells but not in MCF-7 cells . Negative_regulation PLAU HDAC1 17923479 1830348 *Induction* of [uPA] expression by inhibitors trichostatin A (TSA) , sodium butyrate , and scriptaid was observed in all three different types of human cancer cells examined . Negative_regulation PLAU HDAC1 17923479 1830354 In vitro Matrigel invasion assays showed that *induction* of [uPA] expression by inhibitors in human cancer cells resulted in a significant increase of cancer cell invasion . Negative_regulation PLAU HDAC1 20663859 2305223 *Induction* of [uPA] expression by inhibitors trichostatin A and sodium butyrate was observed in CB- and BM-derived MSCs examined . Negative_regulation PLAU HDAC1 20663859 2305234 In vitro migration assays showed that *induction* of [uPA] expression by inhibitors in CB- and BM-derived MSCs significantly enhanced tumor tropism of these cells . Negative_regulation PLAU HDAC10 12198113 997925 The inhibitor , Trichostatin A , *induces* the expression of the [uPA] gene in MDA-MB-231 cells but not in MCF-7 cells . Negative_regulation PLAU HDAC10 20663859 2305221 *Induction* of [uPA] expression by inhibitors trichostatin A and sodium butyrate was observed in CB- and BM-derived MSCs examined . Negative_regulation PLAU HDAC10 20663859 2305232 In vitro migration assays showed that *induction* of [uPA] expression by inhibitors in CB- and BM-derived MSCs significantly enhanced tumor tropism of these cells . Negative_regulation PLAU HDAC11 12198113 997926 The inhibitor , Trichostatin A , *induces* the expression of the [uPA] gene in MDA-MB-231 cells but not in MCF-7 cells . Negative_regulation PLAU HDAC11 20663859 2305222 *Induction* of [uPA] expression by inhibitors trichostatin A and sodium butyrate was observed in CB- and BM-derived MSCs examined . Negative_regulation PLAU HDAC11 20663859 2305233 In vitro migration assays showed that *induction* of [uPA] expression by inhibitors in CB- and BM-derived MSCs significantly enhanced tumor tropism of these cells . Negative_regulation PLAU HDAC2 12198113 997928 The inhibitor , Trichostatin A , *induces* the expression of the [uPA] gene in MDA-MB-231 cells but not in MCF-7 cells . Negative_regulation PLAU HDAC2 17923479 1830349 *Induction* of [uPA] expression by inhibitors trichostatin A (TSA) , sodium butyrate , and scriptaid was observed in all three different types of human cancer cells examined . Negative_regulation PLAU HDAC2 17923479 1830355 In vitro Matrigel invasion assays showed that *induction* of [uPA] expression by inhibitors in human cancer cells resulted in a significant increase of cancer cell invasion . Negative_regulation PLAU HDAC2 20663859 2305224 *Induction* of [uPA] expression by inhibitors trichostatin A and sodium butyrate was observed in CB- and BM-derived MSCs examined . Negative_regulation PLAU HDAC2 20663859 2305235 In vitro migration assays showed that *induction* of [uPA] expression by inhibitors in CB- and BM-derived MSCs significantly enhanced tumor tropism of these cells . Negative_regulation PLAU HDAC3 12198113 997929 The inhibitor , Trichostatin A , *induces* the expression of the [uPA] gene in MDA-MB-231 cells but not in MCF-7 cells . Negative_regulation PLAU HDAC3 20663859 2305225 *Induction* of [uPA] expression by inhibitors trichostatin A and sodium butyrate was observed in CB- and BM-derived MSCs examined . Negative_regulation PLAU HDAC3 20663859 2305236 In vitro migration assays showed that *induction* of [uPA] expression by inhibitors in CB- and BM-derived MSCs significantly enhanced tumor tropism of these cells . Negative_regulation PLAU HDAC4 12198113 997920 The inhibitor , Trichostatin A , *induces* the expression of the [uPA] gene in MDA-MB-231 cells but not in MCF-7 cells . Negative_regulation PLAU HDAC4 20663859 2305216 *Induction* of [uPA] expression by inhibitors trichostatin A and sodium butyrate was observed in CB- and BM-derived MSCs examined . Negative_regulation PLAU HDAC4 20663859 2305227 In vitro migration assays showed that *induction* of [uPA] expression by inhibitors in CB- and BM-derived MSCs significantly enhanced tumor tropism of these cells . Negative_regulation PLAU HDAC5 12198113 997924 The inhibitor , Trichostatin A , *induces* the expression of the [uPA] gene in MDA-MB-231 cells but not in MCF-7 cells . Negative_regulation PLAU HDAC5 20663859 2305220 *Induction* of [uPA] expression by inhibitors trichostatin A and sodium butyrate was observed in CB- and BM-derived MSCs examined . Negative_regulation PLAU HDAC5 20663859 2305231 In vitro migration assays showed that *induction* of [uPA] expression by inhibitors in CB- and BM-derived MSCs significantly enhanced tumor tropism of these cells . Negative_regulation PLAU HDAC6 12198113 997921 The inhibitor , Trichostatin A , *induces* the expression of the [uPA] gene in MDA-MB-231 cells but not in MCF-7 cells . Negative_regulation PLAU HDAC6 20663859 2305217 *Induction* of [uPA] expression by inhibitors trichostatin A and sodium butyrate was observed in CB- and BM-derived MSCs examined . Negative_regulation PLAU HDAC6 20663859 2305228 In vitro migration assays showed that *induction* of [uPA] expression by inhibitors in CB- and BM-derived MSCs significantly enhanced tumor tropism of these cells . Negative_regulation PLAU HDAC7 12198113 997923 The inhibitor , Trichostatin A , *induces* the expression of the [uPA] gene in MDA-MB-231 cells but not in MCF-7 cells . Negative_regulation PLAU HDAC7 20663859 2305219 *Induction* of [uPA] expression by inhibitors trichostatin A and sodium butyrate was observed in CB- and BM-derived MSCs examined . Negative_regulation PLAU HDAC7 20663859 2305230 In vitro migration assays showed that *induction* of [uPA] expression by inhibitors in CB- and BM-derived MSCs significantly enhanced tumor tropism of these cells . Negative_regulation PLAU HDAC8 12198113 997919 The inhibitor , Trichostatin A , *induces* the expression of the [uPA] gene in MDA-MB-231 cells but not in MCF-7 cells . Negative_regulation PLAU HDAC8 20663859 2305215 *Induction* of [uPA] expression by inhibitors trichostatin A and sodium butyrate was observed in CB- and BM-derived MSCs examined . Negative_regulation PLAU HDAC8 20663859 2305226 In vitro migration assays showed that *induction* of [uPA] expression by inhibitors in CB- and BM-derived MSCs significantly enhanced tumor tropism of these cells . Negative_regulation PLAU HDAC9 12198113 997922 The inhibitor , Trichostatin A , *induces* the expression of the [uPA] gene in MDA-MB-231 cells but not in MCF-7 cells . Negative_regulation PLAU HDAC9 20663859 2305218 *Induction* of [uPA] expression by inhibitors trichostatin A and sodium butyrate was observed in CB- and BM-derived MSCs examined . Negative_regulation PLAU HDAC9 20663859 2305229 In vitro migration assays showed that *induction* of [uPA] expression by inhibitors in CB- and BM-derived MSCs significantly enhanced tumor tropism of these cells . Negative_regulation PLAU HGF 17992475 1860057 *Role* of signaling in regulating [urokinase plasminogen activator] on invasiveness in human hepatocellular carcinoma : a potential therapeutic target . Negative_regulation PLAU HNF1B 7665606 322017 *Role* of in cell-specific cAMP induction of the [urokinase-type plasminogen activator] gene . Negative_regulation PLAU HOXD3 10495851 647141 Furthermore , the overexpression of *increased* mRNA expressions of [urokinase-type plasminogen activator] and transcription factors ets-1 and -2 . Negative_regulation PLAU HOXD3 9314544 455540 Expression of , in the absence of bFGF , *resulted* in enhanced expression of integrin alphavbeta3 and [uPA] . Negative_regulation PLAU HRAS 15618232 1375572 However , expression and activity of the metastatic gene [uPA] and invasive capacity of the cells were significantly *reduced* by the oncogene . Negative_regulation PLAU IL10 23183001 2730237 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL11 23183001 2730238 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL13 23183001 2730239 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL15 23183001 2730240 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL16 23183001 2730241 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL18 23183001 2730242 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL19 23183001 2730243 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL1B 10892857 711306 Both and TNF-alpha *induced* a significant decrease in [uPA] expression in PBF , whereas bFGF induced a slight increase in both HJF and PBF . Negative_regulation PLAU IL1B 7552526 323256 *suppressed* production of [uPA] and tPA in both types of SMCs . Negative_regulation PLAU IL2 23183001 2730244 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL20 23183001 2730245 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL21 23183001 2730246 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL22 23183001 2730229 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL24 23183001 2730227 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL25 23183001 2730228 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL26 23183001 2730233 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL27 23183001 2730234 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL3 23183001 2730247 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL31 23183001 2730235 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL32 23183001 2730232 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL33 23183001 2730231 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL34 23183001 2730236 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL37 23183001 2730230 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL4 11781145 900165 DEX and could also *suppress* the expression of [urokinase type plasminogen activator] ( uPA ) to prevent the conversion from the proenzyme form of MMP-9 to its active form . Negative_regulation PLAU IL4 23183001 2730248 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL5 23183001 2730249 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL6 23183001 2730250 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL7 23183001 2730251 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL8 16410222 1494761 Importantly , atorvastatin at the micromolar concentrations diminished the production of , a proinflammatory and proangiogenic chemokine , and *inhibited* the synthesis of [urokinase plasminogen activator (uPA)] , a potent proinflammatory mediator . Negative_regulation PLAU IL8 23183001 2730252 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU IL9 23183001 2730253 Our results demonstrated that strongly *inhibits* [urokinase type plasminogen activator] expression during myogenic differentiation . Negative_regulation PLAU ILF3 22986534 2833261 Nuclear localization of ILF3 highlights the *role* of in sustained [uPA] expression as a transcription activator and pri-miRNA processing blocker . Negative_regulation PLAU ILK 17187779 1695317 Further , *reduced* the basal and TGFbeta1 stimulated secretion of [uPA] , and increased the secretion of its inhibitor ( PAI-1 ) . Negative_regulation PLAU INS 1576255 187320 also stimulated uPa and tPa production by prepubertal Sertoli cells , and retinol significantly *suppressed* [uPa] production and the ability of FSH to stimulate tPa production by midpubertal Sertoli cells . Negative_regulation PLAU JUN 11248416 793542 ( anti-AP-1 ) transcriptional activity of non-cytotoxic concentrations of berberine *caused* the inhibition of the invasiveness of LLC cells through the repression of expression of [urokinase-type plasminogen activator] ( u-PA ) . Negative_regulation PLAU JUNB 15558021 1361115 Upregulation of expression in MEKK1-/- cells forms an inhibitory AP-1 complex that binds to the uPA promoter and *inhibits* [uPA] transcription . Negative_regulation PLAU KHSRP 16912916 1614850 Rank-order expression of ( NTR ) greatly *reduced* protein levels and enzymatic activities of [uPA] , MMP-2 , and MMP-9 as shown by immunoblot and zymography analyses . Negative_regulation PLAU KLF6 10666204 665398 Furthermore , concomitant expression of Zf9 and uPA proteins was observed in arterial endothelial cells after balloon injury in rats , suggesting a potential *role* of in [uPA] expression not only in vitro but also in vivo . Negative_regulation PLAU KLKB1 1917142 168251 Chymotrypsin , plasmin and were inhibited to a lesser extent , but [urokinase-type plasminogen activator] , elastase , thrombin and papain were not *inhibited* . Negative_regulation PLAU KRAS 15618232 1375573 However , expression and activity of the metastatic gene [uPA] and invasive capacity of the cells were significantly *reduced* by the oncogene . Negative_regulation PLAU KRT8 19845941 2160221 , therefore , function also as a receptor for uPA on the cell surface , and the presence of anti-CK MAb may *prevent* the binding of [uPA] to a designated CK8 motif . Negative_regulation PLAU LCK 14699120 1211595 DN and inhibitors of Lck , EGF receptor , and MEK-1 *suppressed* H/R induced [uPA] secretion and cell motility . Negative_regulation PLAU LCK 16474166 1548358 Moreover , Syk and play differential roles in regulating Sp1 activation and expressions of melanoma cell adhesion molecule (MelCAM) , urokinase-type plasminogen activator ( uPA ) , matrix metalloproteinase-9 (MMP-9) , and vascular endothelial growth factor ( VEGF ) in response to H/R. Overexpression of wild type Syk *inhibited* the H/R induced [uPA] , MMP-9 , and VEGF expression but up-regulated MelCAM expression . Negative_regulation PLAU LPA 10589790 572233 In contrast , expression of the edg-4 LPA receptor was markedly increased in ovarian cancer cell lines as compared with NOE cell lines , raising the possibility that the edg-4 receptor *contributes* to the ability of ovarian cancer cells but not NOE cells to produce [uPA] in response to LPA . Negative_regulation PLAU LPAR2 18461672 1909843 To explore the *role* of in regulating lysophosphatidic acid (LPA) induced [urokinase plasminogen activator (uPA)] activation , cell invasion , and migration in human ovarian cancer cell line SKOV-3 . Negative_regulation PLAU LRPAP1 1378833 192683 The inhibitor enhanced [uPA] degradation was *blocked* by r and inhibited by polyclonal anti-alpha 2MR/LRP antibodies . Negative_regulation PLAU MAP2K3 12377770 1019976 Using constitutively active MAPK kinases , we found that both constitutively active MKK3 and MKK6 mutants were able to activate p38 MAPK and up-regulate uPA expression , but only dominant negative *blocked* alphav integrin mediated p38 MAPK activation and [uPA] up-regulation . Negative_regulation PLAU MAP3K1 9671463 519904 , a specific JNK activator , *induced* transcription from the uPA promoter in the absence of UV treatment , whereas coexpression of catalytically inactive MEKK1 ( K432M ) and of cytoplasmic JNK inhibitor JIP-1 inhibited UV-induced [uPA] transcriptional activity . Negative_regulation PLAU MAP6 23810810 2849272 In this study , we first examined the effect of TGF-ß2 and/or the *inhibitor* of [uPA] ( ( ® ) ) on the proliferation of a human retinal pigment epithelial cell line ( ARPE-19 cells ) . Negative_regulation PLAU MAPK1 11606583 888451 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 and *inhibited* cell associated [uPA] expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation PLAU MAPK1 8761947 378258 Moreover , the expression of a dominant negative ERK1 , but not , *repressed* [urokinase-type plasminogen activator] promoter activity . Negative_regulation PLAU MAPK10 11606583 888452 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 and *inhibited* cell associated [uPA] expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation PLAU MAPK11 11606583 888453 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 and *inhibited* cell associated [uPA] expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation PLAU MAPK12 11606583 888454 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 and *inhibited* cell associated [uPA] expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation PLAU MAPK13 11606583 888455 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 and *inhibited* cell associated [uPA] expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation PLAU MAPK14 11606583 888456 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 and *inhibited* cell associated [uPA] expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation PLAU MAPK15 11606583 888450 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 and *inhibited* cell associated [uPA] expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation PLAU MAPK3 11606583 888457 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 and *inhibited* cell associated [uPA] expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation PLAU MAPK3 8761947 378259 Moreover , the expression of a dominant negative , but not ERK2 , *repressed* [urokinase-type plasminogen activator] promoter activity . Negative_regulation PLAU MAPK4 11606583 888458 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 and *inhibited* cell associated [uPA] expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation PLAU MAPK6 11606583 888459 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 and *inhibited* cell associated [uPA] expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation PLAU MAPK7 11606583 888460 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 and *inhibited* cell associated [uPA] expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation PLAU MAPK8 11606583 888461 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 and *inhibited* cell associated [uPA] expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation PLAU MAPK8IP1 9671463 519905 MEKK1 , a specific JNK activator , induced transcription from the uPA promoter in the absence of UV treatment , whereas coexpression of catalytically inactive MEKK1 ( K432M ) and of cytoplasmic JNK inhibitor *inhibited* UV-induced [uPA] transcriptional activity . Negative_regulation PLAU MAPK9 11606583 888462 In the present study , we found that blocking alpha ( v ) integrin functionality with a function blocking monoclonal antibody or down regulating alpha ( v ) integrin expression with alpha ( v ) -specific antisense oligonucleotides significantly decreased the levels of active p38 and *inhibited* cell associated [uPA] expression in invasive breast cancer MDA-MB-231 cells . Negative_regulation PLAU MAPKAPK2 14517288 1147350 These results indicate a *role* for HuR and in regulating the expression of [uPA] and uPAR genes at the posttranscriptional level . Negative_regulation PLAU MCAM 16474166 1548359 Moreover , Syk and Lck play differential roles in regulating Sp1 activation and expressions of , urokinase-type plasminogen activator ( uPA ) , matrix metalloproteinase-9 (MMP-9) , and vascular endothelial growth factor ( VEGF ) in response to H/R. Overexpression of wild type Syk *inhibited* the H/R induced [uPA] , MMP-9 , and VEGF expression but up-regulated MelCAM expression . Negative_regulation PLAU MET 17992475 1860058 *Role* of hepatocyte growth signaling in regulating [urokinase plasminogen activator] on invasiveness in human hepatocellular carcinoma : a potential therapeutic target . Negative_regulation PLAU MMP1 14515149 1147033 In conclusion , we postulate that 15d-PGJ ( 2 ) may differently regulate the synthesis of proteases involved in angiogenesis : it upregulates expression in HMEC-1 through induction of oxidative stress , and *inhibits* [uPA] synthesis partly by activation of PPARgamma . Negative_regulation PLAU MMP9 16474166 1548360 Moreover , Syk and Lck play differential roles in regulating Sp1 activation and expressions of melanoma cell adhesion molecule (MelCAM) , urokinase-type plasminogen activator ( uPA ) , , and vascular endothelial growth factor ( VEGF ) in response to H/R. Overexpression of wild type Syk *inhibited* the H/R induced [uPA] , MMP-9 , and VEGF expression but up-regulated MelCAM expression . Negative_regulation PLAU MMP9 19693769 2150958 Our results , therefore , suggest that B-DIM down-regulates [uPA-uPAR] in aggressive breast cancers but in the absence of uPA-uPAR , B-DIM can directly *inhibit* VEGF and leading to the inhibition of cell growth and migration of breast cancer cells . Negative_regulation PLAU MMP9 20716639 2317899 [Urokinase plasminogen activator] receptor and/or *inhibition* induces apoptosis signaling through lipid rafts in glioblastoma xenograft cells . Negative_regulation PLAU MYLIP 19490101 2091278 The evidence obtained shows that overexpression of *leads* to [uPA] and c-met downregulation and to decreased migration and proliferation abilities of HCC cells . Negative_regulation PLAU MYLIP 21242962 2431049 uPA is the target gene for miR-23b as the *repressed* [uPA] expression and interacted with the 3'-untranslated region of uPA mRNA . Negative_regulation PLAU MYLIP 21670079 2460035 Inhibition of expression by Max and RXRa *activates* K-Ras and [PLAU] to mediate distinct aspects of cellular transformation . Negative_regulation PLAU MYLIP 22491710 2589418 Moreover , *repressed* the expressions of cyclin D1 and [urokinase-type plasminogen activator] in A549 cells . Negative_regulation PLAU NA 7957773 278098 TNF alpha increased the steady state level of [urokinase-type plasminogen activator] ( uPA ) , and *inhibited* this increase at a dose that also inhibited the increase in the intracellular oxidation state . Negative_regulation PLAU NDUFA13 20478305 2283378 Additionally , upregulation of also *suppressed* secretion of [urokinase-type plasminogen activator] ( u-PA ) , matrix metalloproteinase (MMP)-2 , 9 and vascular endothelial growth factor ( VEGF ) . Negative_regulation PLAU NFATC1 23826864 2838965 In cultured podocytes , the increased nuclear accumulation of NFAT2 and [uPA] receptor expression induced by high glucose treatment was *prevented* by 11R-VIVIT or ; Negative_regulation PLAU NFKB1 16109653 1445272 To evaluate the *role* of transcription factor in [uPA] and uPAR gene transcription with H. pylori stimulation , the effect of NF-kappaB inhibitor MG132 on H. pylori induced uPA and uPAR mRNA expression was examined . Negative_regulation PLAU NFKB1 20502321 2301207 *dependent* regulation of [urokinase plasminogen activator] by proanthocyanidin-rich grape seed extract : effect on invasion by prostate cancer cells . Negative_regulation PLAU NFKBIA 9914486 586960 Overexpression of RelA significantly *enhanced* [uPA] promoter activity , whereas overexpression reduced uPA promoter activity by 40 % . Negative_regulation PLAU NPEPPS 8847146 338099 did not enhance or *impair* the activity of the 2-chain form of [uPA] . Negative_regulation PLAU NPY6R 16407820 1560969 Moreover , ErbB2 mediated upregulation of [urokinase-type plasminogen activator] receptor ( uPAR ) is *reduced* by either the PKCalpha inhibitor Go6976 or the Src inhibitor , and the combination of Go6976 with PP2 is superior to either agent alone in suppressing uPAR expression and cell invasion . Negative_regulation PLAU NRAS 15618232 1375574 However , expression and activity of the metastatic gene [uPA] and invasive capacity of the cells were significantly *reduced* by the oncogene . Negative_regulation PLAU OSM 10967551 728298 *stimulated* increased mRNA levels of urokinase-plasminogen activator (uPA) and [urokinase-plasminogen activator] receptor ( uPAR ) in a time and dose dependent manner . Negative_regulation PLAU PAEP 19520712 2116030 also significantly *reduced* the expression , secretion and activity of [uPA] ( P < 0.05 ) . Negative_regulation PLAU PBK 15880258 1406200 Our results suggest that is *involved* in the regulation of [uPA] expression , which might provide a new clue to further understanding the regulation mechanism of uPA expression . Negative_regulation PLAU PLAT 16763560 1576473 double-deficient wounds to a degree indistinguishable from that observed in Plg-deficient mice , and completely *blocks* the activity of pKal , but not [uPA] and tPA in wound extracts . Negative_regulation PLAU PLAT 7711210 298036 TGF alpha increased basal activity at both stages of follicular development but *inhibited* activities of [uPA] in undifferentiated granulosa cells , irrespective of the presence of FSH . Negative_regulation PLAU PLAT 8119140 250590 Interestingly , whereas mRNA levels , like those of TGF beta 2 and -beta 3 , were barely detectable in adult prostatic tissues , mRNA levels for [urokinase plasminogen activator] , androgen receptor , and c-myc were readily *detected* and expressed in a lobe-specific fashion . Negative_regulation PLAU PLAUR 1315748 185508 Three different treatments , competition with the agonist amino-terminal fragment of uPA , treatment with a monoclonal antibody directed toward the binding domain of uPAR or release of from the cell surface with phosphatidylinositol-specific phospholipase C completely *prevented* [uPA] . PAI-1 degradation . Negative_regulation PLAU PLAUR 17134505 1661450 Absence of alone or the combined absence of uPAR and tPA had no impact on the resolution of centrilobular injury , but the loss of receptor-free [uPA] significantly *impaired* the clearance of necrotic hepatocytes up to 14 days after CCl4 . Negative_regulation PLAU PLAUR 19330806 2080415 Moreover , we found that uPA as well as induced the production of VEGF and MMP-9 , and that the down-regulation of [uPA/uPAR] by siRNAs or B-DIM treatment *resulted* in the inhibition of VEGF and MMP-9 secretion which could be responsible for the observed inhibition of cell migration . Negative_regulation PLAU PLAUR 20403162 2274084 In the present study we characterized the expression of the urokinase plasminogen activator (uPA) , its cognate receptor ( ) and the [uPA] *inhibitors* PAI-1 and PAI-2 in normal human testis and seminomas . Negative_regulation PLAU PLAUR 20624254 2297087 Serum and induced sputum levels of urokinase-type plasminogen activator ( uPA ) , urokinase-type plasminogen activator receptor ( ) , [urokinase-type plasminogen activator] *inhibitor* ( PAI-1 ) and human cationic antimicrobial protein 18 ( CAP18 ) were measured by ELISA , in 13 patients with stage I or stage II COPD ( COPD I + II ) , 15 patients with stage III or stage IV COPD ( COPD III + IV ) , 18 healthy non-smokers and 14 healthy smokers . Negative_regulation PLAU PLG 11504687 847824 At the cellular level , particulate nickel subsulfide inhibits fibrinolysis by transcriptionally inducing expression of , an *inhibitor* of the [urokinase-type plasminogen activator] . Negative_regulation PLAU PLG 12041693 949770 No evidence was found for the presence of [urokinase-type plasminogen activator] , activator *inhibitors* or plasmin inhibitors in bovine oocyte cortical granule extracts . Negative_regulation PLAU PLG 12147618 970048 The serine proteases tissue plasminogen activator (t-PA) and [urokinase plasminogen activator (u-PA)] and their inhibitor , , *regulate* a variety of processes involved in tissue morphogenesis and differentiation . Negative_regulation PLAU PLG 14718842 1197623 Assays of DNA synthesis , cell proliferation , and migration were performed in response to [sc-uPA] , ATF , kringle , and CTF in the *presence* and absence of the inhibitors epsilon-aminocaproic acid ( EACA ) and aprotinin , the Galphai inhibitor pertussis toxin , and the mitogen activated protein kinase 1 ( the upstream regulator of the extracellular-signal regulated kinase [ ERK ] ) inhibitor PD98059 . Negative_regulation PLAU PLG 15353482 1359039 In contrast , neither Glunor *inhibits* the activation of plasminogen by 2-chain [uPA] . Negative_regulation PLAU PLG 17606760 1792588 The generation of involved expression of urokinase-type plasminogen activator ( uPA ) and its receptor ( uPAR ) at the surface of EMPs and was further *increased* by their ability to bind exogenous [uPA] on uPAR . Negative_regulation PLAU PLG 17939964 1844450 [Urokinase plasminogen activator (uPA)] was constitutively expressed on neuronal membrane fractions , and amiloride ( an antagonist of uPA ) or significantly *reduced* IL-1beta induced neurotoxicity . Negative_regulation PLAU PLG 1917142 168252 Chymotrypsin , and kallikrein were inhibited to a lesser extent , but [urokinase-type plasminogen activator] , elastase , thrombin and papain were not *inhibited* . Negative_regulation PLAU PLG 2942403 60775 Selective use of these monoclonal antibodies demonstrated unequivocally that *mediates* the activation of the proenzyme form of [urokinase-type plasminogen activator] . Negative_regulation PLAU PLG 7556451 327682 [uPA] is *regulated* by the activator inhibitors PAI-1 and PAI-2 . Negative_regulation PLAU PLG 9268189 449769 Inhibition of activity or *inhibition* of [urokinase-type plasminogen activator] ( u-PA ) activity resulted in approximately 40 % reduction of migration after 24 h in the wound assay and an even stronger reduction ( 70-80 % ) in the matrix invasion assay . Negative_regulation PLAU PON1 22155455 2542702 *reduces* atherosclerotic lesion oxidative stress , whereas [urokinase-type plasminogen activator] ( uPA ) increases oxidative stress in atherosclerotic lesions and contributes to the progression and complications of atherosclerosis . Negative_regulation PLAU PRDX2 20559690 2315796 , a HDAC inhibitor , decreased HGF induced HADC-5 expression and also *repressed* [uPA] and MMP-9 expression . Negative_regulation PLAU PRM1 8868466 389273 The results show that FGF-2 antagonists suramin , , heparin , the synthetic peptide FGF-2 ( 112-155 ) , and a soluble form of FGFR-1 do not *inhibit* FGF-2 mediated [uPA] up-regulation at concentrations that affect growth factor binding to cell surface receptors and mitogenic activity . Negative_regulation PLAU PRM2 8868466 389274 The results show that FGF-2 antagonists suramin , , heparin , the synthetic peptide FGF-2 ( 112-155 ) , and a soluble form of FGFR-1 do not *inhibit* FGF-2 mediated [uPA] up-regulation at concentrations that affect growth factor binding to cell surface receptors and mitogenic activity . Negative_regulation PLAU PRM3 8868466 389270 The results show that FGF-2 antagonists suramin , , heparin , the synthetic peptide FGF-2 ( 112-155 ) , and a soluble form of FGFR-1 do not *inhibit* FGF-2 mediated [uPA] up-regulation at concentrations that affect growth factor binding to cell surface receptors and mitogenic activity . Negative_regulation PLAU PTK2 10471383 641776 Furthermore , expression of either , a kinase-minus FAK-like molecule acting as a dominant negative FAK , or a dominant negative Src *suppressed* CSR induced [uPA] gene promoter activation . Negative_regulation PLAU PTTG1IP 10892857 711304 Both IL-1beta and TNF-alpha *induced* a significant decrease in [uPA] expression in PBF , whereas bFGF induced a slight increase in both HJF and . Negative_regulation PLAU RBBP4 17923479 1830350 *Induction* of [uPA] expression by inhibitors trichostatin A (TSA) , sodium butyrate , and scriptaid was observed in all three different types of human cancer cells examined . Negative_regulation PLAU RBBP4 17923479 1830356 In vitro Matrigel invasion assays showed that *induction* of [uPA] expression by inhibitors in human cancer cells resulted in a significant increase of cancer cell invasion . Negative_regulation PLAU RBBP7 17923479 1830351 *Induction* of [uPA] expression by inhibitors trichostatin A (TSA) , sodium butyrate , and scriptaid was observed in all three different types of human cancer cells examined . Negative_regulation PLAU RBBP7 17923479 1830357 In vitro Matrigel invasion assays showed that *induction* of [uPA] expression by inhibitors in human cancer cells resulted in a significant increase of cancer cell invasion . Negative_regulation PLAU RELA 10467400 640766 Overexpression of [urokinase-type plasminogen activator] in pancreatic adenocarcinoma is *regulated* by constitutively activated . Negative_regulation PLAU RELA 16109653 1445273 To evaluate the *role* of transcription factor in [uPA] and uPAR gene transcription with H. pylori stimulation , the effect of NF-kappaB inhibitor MG132 on H. pylori induced uPA and uPAR mRNA expression was examined . Negative_regulation PLAU RELA 20502321 2301208 *dependent* regulation of [urokinase plasminogen activator] by proanthocyanidin-rich grape seed extract : effect on invasion by prostate cancer cells . Negative_regulation PLAU RELA 9914486 586961 Overexpression of significantly *enhanced* [uPA] promoter activity , whereas IkappaB-alpha overexpression reduced uPA promoter activity by 40 % . Negative_regulation PLAU RELA 9914486 586962 These data were supported by the finding that endogenous [uPA] was also *increased* sixfold by overexpression of and decreased by 30 % upon overexpression of IkappaB-alpha . Negative_regulation PLAU SERPINA5 17258797 1783463 [uPA] activity is controlled by its principal inhibitor , the PA inhibitor type-1 (PAI-1) , but it can also be *inhibited* by . Negative_regulation PLAU SERPINA5 9365930 463184 Plasma [uPA] is *inhibited* by the serine protease inhibitor by the insertion of PCI 's reactive site loop into the active site of the protease . Negative_regulation PLAU SERPINB12 11604408 888358 This hypothesis was confirmed because recombinant *inhibited* human trypsin and plasmin but not thrombin , coagulation factor Xa , or [urokinase-type plasminogen activator] . Negative_regulation PLAU SERPINB2 10759957 683250 The urokinase-type plasminogen activator system ( uPAS ) , consisting of the urokinase plasminogen activator (uPA) , the [uPA receptor (uPA-R)] , and their corresponding *inhibitors* , PAI-1 and , is thought to play a role in this process . Negative_regulation PLAU SERPINB2 11063652 746779 The aim of this study was to determine the level of mRNA expression for the genes encoding urokinase ( [uPA] ) , urokinase receptor ( uPAR ) , and plasminogen activator *inhibitor* ( ) in endometrial carcinomas . Negative_regulation PLAU SERPINB2 12813409 1103134 , amiloride , *blocked* [uPA] activity in retinal extracts . Negative_regulation PLAU SERPINB2 15944795 1416344 The plasminogen activator (PA) system comprises the 2 serine proteases , [urokinase PA (uPA)] and tissue PA (tPA) , the 2 serpin *inhibitors* , PAI-1 and and the uPA receptor ( uPAR ; Negative_regulation PLAU SERPINB2 16611153 1545298 The central components of the PA system are the proteolytic activators , [urokinase-plasminogen activator (u-PA)] and tissue-type plasminogen activator (t-PA) , plasminogen (plg) and its degradation product , plasmin , together with the major *inhibitors* of this system , ( PAI-1 , PAI-2 ) . Negative_regulation PLAU SERPINB2 16882037 1594549 Reciprocal upregulation of [urokinase plasminogen activator] and its *inhibitor* , , by Borrelia burgdorferi affects bacterial penetration and host-inflammatory response . Negative_regulation PLAU SERPINB2 17237280 1689806 We also present novel data showing that human *inhibited* murine [uPA] and was specifically endocytosed by murine fibroblast cells . Negative_regulation PLAU SERPINB2 18162327 1883064 The endogenous inhibitors of this system , PAI-1 and , *regulate* [uPA-uPAR] activity by either direct inhibition or affecting cell surface expression and internalization . Negative_regulation PLAU SERPINB2 20496126 2395187 In the colon , the [urokinase-type plasminogen activator] ( uPA ) , its receptor ( uPAR ) , and plasminogen activator *inhibitors* , PAI-1 and , are implicated in the transition from mucosa to adenoma and tumour progression . Negative_regulation PLAU SERPINB2 21086717 2349993 Although *inhibits* [urokinase plasminogen activator] in vitro , evidence that this represents its physiological role in vivo is not compelling . Negative_regulation PLAU SERPINB2 23661500 2955426 In this study , using genome-wide gene expression analysis to investigate potential molecular mediators of HNSCC chemoresistance , we identified , a known *inhibitor* of extracellular serine proteinase [urokinase-type plasminogen activator] ( uPA ) , as an important candidate . Negative_regulation PLAU SERPINB2 7556451 327679 Differential expression of [urokinase-type plasminogen activator] ( uPA ) , its receptor ( uPA-R ) , and *inhibitor* type-2 ( ) during differentiation of keratinocytes in an organotypic coculture system . Negative_regulation PLAU SERPINB2 8388810 220270 Complexes between the [urokinase-type plasminogen activator] ( uPA ) and its type-2 *inhibitor* ( ) are bound by a cell-surface receptor for uPA and rapidly cleaved into two fragments of 70 and 22 kDa . Negative_regulation PLAU SERPINB5 10987285 732446 Purified recombinant produced in baculovirus infected Spodoptera frugiperda Sf9 insect cells [ rMaspin ( i ) ] binds specifically to the surface of DU145 cells , *inhibits* the DU145 cell surface bound [uPA] , and forms a stable complex with the uPA in DU145 cell lysate . Negative_regulation PLAU SERPINB5 11751384 889883 In addition , expression *led* to a dramatic reduction in the release of active [uPA] , both high molecular weight and the low molecular weight , into the conditioned culture medium . Negative_regulation PLAU SERPINB5 12788977 1100899 Previously , we showed that , a serine protease inhibitor , specifically *inhibits* PC-associated [uPA] and PC cell invasion and motility in vitro . Negative_regulation PLAU SERPINB5 16618739 1551069 Although does not directly *inhibit* [urokinase-type plasminogen activator] ( uPA ) activity , we have shown evidence that maspin may block the pericellular proteolysis mediated by cell surface associated uPA . Negative_regulation PLAU SERPINE1 10094378 601103 Ninety-eight patients with histologically confirmed ovarian tumors ( 77 primary ovarian carcinomas of stages T1 to T3 according to the postoperative histopathological classification pTNM classification , 14 ovarian metastases of various origins and seven benign ovarian tumors ) were investigated with regard to the concentration of [urokinase-type plasminogen activator] ( uPA ) and plasminogen activator *inhibitor* ( ) in membrane extracts of tumors . Negative_regulation PLAU SERPINE1 10098758 601736 Prognostic impact of [urokinase-type plasminogen activator] ( uPA ) and its *inhibitor* ( ) in cytosols and pellet extracts derived from 892 breast cancer patients . Negative_regulation PLAU SERPINE1 10098758 601738 To evaluate the clinical relevance of [urokinase-type plasminogen activator] ( uPA ) and its type-1 *inhibitor* ( ) measured by a recently developed enzyme linked immunosorbent assay ( ELISA ) , we analysed both components in samples derived from 892 patients with primary breast cancer ( median follow-up 99 months ) . Negative_regulation PLAU SERPINE1 10209959 607480 We show here that hK2 rapidly forms a complex with ( PAI-1 ) , the primary *inhibitor* of [uPA] in tissues . Negative_regulation PLAU SERPINE1 10430786 633628 The complex between urokinase ( [uPA] ) and its type-1 *inhibitor* ( ) is formed exclusively from the active forms of these components ; Negative_regulation PLAU SERPINE1 10759957 683249 The urokinase-type plasminogen activator system ( uPAS ) , consisting of the urokinase plasminogen activator (uPA) , the [uPA receptor (uPA-R)] , and their corresponding *inhibitors* , and PAI-2 , is thought to play a role in this process . Negative_regulation PLAU SERPINE1 10995898 733658 The serine protease [urokinase-type plasminogen activator] ( uPA ) , its *inhibitor* ( ) , and its receptor ( uPAR ; Negative_regulation PLAU SERPINE1 11000131 734415 This study demonstrates that hyaluronan fragments augment steady-state mRNA , protein , and inhibitory activity of as well as diminish the baseline levels of uPA mRNA and *inhibit* [uPA] activity in an alveolar macrophage cell line . Negative_regulation PLAU SERPINE1 11205273 763523 High levels of TIMP1 and present in S variant *reduce* MMP9 and [uPA] activities , respectively . Negative_regulation PLAU SERPINE1 11238529 790738 In addition , the plasminogen activator system , especially [urokinase plasminogen activator (u-PA)] , plasminogen activator *inhibitor* ( ) , and u-PA receptor (u-PAR) , are crucial during embryo implantation . Negative_regulation PLAU SERPINE1 11286474 799864 Whereas HMEC-proliferation was stimulated by AR , the levels of secreted [urokinase-type plasminogen activator] ( uPA ) and type-1 plasminogen activator *inhibitor* ( ) remained unaffected . Negative_regulation PLAU SERPINE1 11304683 803755 Dedifferentiation of serous ovarian cancer from cystic to solid tumors is associated with increased expression of mRNA for [urokinase plasminogen activator (uPA)] , its receptor ( uPAR ) and its *inhibitor* ( ) . Negative_regulation PLAU SERPINE1 11304683 803758 We analyzed the mRNAs for [urokinase plasminogen activator (uPA)] , its receptor ( uPAR ) , and *inhibitor* ( ) in serous ovarian tumors by in situ hybridization and by densitometric scanning of Northern blots prepared from tissue extracts . Negative_regulation PLAU SERPINE1 11331280 827459 In contrast , VN *induced* down-regulation of [uPA] and uPAR while increasing by up to 4-fold . Negative_regulation PLAU SERPINE1 11470783 860360 Here , we show that the physiological *inhibitor* of [urokinase-type plasminogen activator] , , is also induced by MNNG in a p53 dependent fashion , because MNNG induced PAI-1 in p53 expressing cells but not in p53-/- cells . Negative_regulation PLAU SERPINE1 11489825 845426 Recent studies suggest that HER-2/neu specifically promotes the invasive capacity of tumor cells by up-regulating secretion of the proteolytic enzyme , [urokinase-type plasminogen activator] ( uPA ) , or its *inhibitor* , ( PAI-1 ) , in colon and gastric cancer . Negative_regulation PLAU SERPINE1 11720826 883988 [Urokinase plasminogen activator] and its *inhibitor* , , in association with progression-free survival in early stage endometrial cancer . Negative_regulation PLAU SERPINE1 11792750 901958 [Urokinase-type plasminogen activator] ( uPA ) and its *inhibitor* ( ) play essential roles in tumor invasion and metastasis . Negative_regulation PLAU SERPINE1 12023852 943977 Paradoxically , high levels of ( PAI-1 ) , an endogenous *inhibitor* of [uPA] , also predict for aggressive disease . Negative_regulation PLAU SERPINE1 12118065 964695 Transcription of c-fos , collagenase , transforming growth factor-beta , actin , [urokinase plasminogen activator] and its type-1 *inhibitor* ( ) appears to be particularly responsive to shape activated signaling pathways . Negative_regulation PLAU SERPINE1 12152654 971404 ( PAI-1 ) , the primary physiological *inhibitor* of both tissue-type plasminogen activator and [urokinase-type plasminogen activator] in plasma , is a well established risk factor in thrombotic diseases . Negative_regulation PLAU SERPINE1 12168869 973712 The plasminogen activator system , including [urokinase-type plasminogen activator] ( uPA ) and type-1 plasminogen activator *inhibitor* ( ) , plays an important role in repair of the peritoneum damaged by several types of peritonitis . Negative_regulation PLAU SERPINE1 12175988 976887 In addition , the [uPA] *inhibitor* , , was not affected by IL-8 . Negative_regulation PLAU SERPINE1 12176977 997664 ( PAI-1 ) , an *inhibitor* of [urokinase plasminogen activator] , is paradoxically associated with a poor prognosis in breast cancer . Negative_regulation PLAU SERPINE1 12192463 980873 *inhibits* tissue plasminogen activator and [urokinase-type plasminogen activator] , resulting in reduced plasminogen activity and attenuated fibrinolysis and proteolysis . Negative_regulation PLAU SERPINE1 12402308 1009511 In our study , we have studied the effects of CD44 stimulation by ligation with HA upon the expression of matrix metalloproteinases ( MMPs ) -2 and -9 as well as [urokinase-type plasminogen activator] ( uPA ) , its receptor ( uPAR ) and its *inhibitor* ( ) and the subsequent induction of invasion of human chondrosarcoma cell line HCS-2/8 . Negative_regulation PLAU SERPINE1 12466358 1022347 The regulated expression of the [urokinase-type plasminogen activator] ( uPA ) and plasminogen activator *inhibitor* ( ) is believed to modulate the invasive capacity of human trophoblastic cells in vitro and in vivo . Negative_regulation PLAU SERPINE1 12543785 1050808 Besides degrading of matrix proteins , PMN-E has been shown to be able to cleave and inactivate plasminogen activator inhibitor-1 ( ) , the main *inhibitor* of [uPA] , and alpha2-antiplasmin , the natural inhibitor of plasmin , thus enabling an uncontrolled matrix degradation by the fibrinolytic enzymes . Negative_regulation PLAU SERPINE1 12546716 1051150 Rb2 greatly or moderately increased the amount of [urokinase-type PA (uPA)] or its *inhibitor* ( ) , present in the culture medium , whereas saponin did not influence mRNA levels of uPA , its surface receptor , and PAI-1 , suggesting that Rb2 may stimulate the secretion of uPA without enhancing its gene expression . Negative_regulation PLAU SERPINE1 12624545 1066611 We have investigated whether there are any differences in the release of [urokinase plasminogen activator (uPA)] and its *inhibitor* ( ) from cultured endometrial and endometriotic stromal cells , and whether the release is regulated by epidermal growth factor (EGF) or transforming growth factor beta1 ( TGFbeta1 ) . Negative_regulation PLAU SERPINE1 12642587 1085789 The plasminogen/plasmin system , [urokinase-type plasminogen activator] ( uPA ) , its receptor ( uPAR ) , and its *inhibitor* ( ) , influence extracellular proteolysis and cell migration in lung injury or neoplasia . Negative_regulation PLAU SERPINE1 12706358 1082639 Immunoassays of urokinase ( [uPA] ) and its type-1 *inhibitor* ( ) in detergent extracts of breast cancer tissue . Negative_regulation PLAU SERPINE1 12967140 1138862 Urokinase-type plasminogen activator ( uPA ) , plasminogen activator *inhibitor* ( ) , and [uPA receptor (uPAR)] are prognostic factors in various cancer types , especially breast cancer . Negative_regulation PLAU SERPINE1 1339823 209231 The concentrations of tissue plasminogen activator (t-PA) , [urokinase plasminogen activator (u-PA)] and plasminogen activator *inhibitor* ( ) have been determined in endometrial curettings obtained from 46 subfertile women during proliferative , early or late secretory phases of the menstrual cycle . Negative_regulation PLAU SERPINE1 14659108 1177369 ( 1 ) [Urokinase-type plasminogen activator] ( UPA ) and type 1 plasminogen activator *inhibitor* ( ) , two molecular markers of invasion already known for their powerful prognostic value in node negative breast cancer , seem to predict for enhanced benefit from adjuvant CT , while the benefit from adjuvant endocrine therapy seems independent of them . Negative_regulation PLAU SERPINE1 14744782 1203790 This system comprises of , among others , the [urokinase-type plasminogen activator] ( uPA ) and its main *inhibitor* ( ) . Negative_regulation PLAU SERPINE1 14981142 1214272 We have previously demonstrated elevated levels of the fibrinolytic factors [urokinase plasminogen activator (uPA)] and plasminogen activator *inhibitor* ( ) in endometriotic tissue and endometrium from women with endometriosis . Negative_regulation PLAU SERPINE1 14983227 1214586 The complex between [urokinase-type plasminogen activator] ( uPA ) and its type-1 *inhibitor* ( ) independently predicts response to first-line endocrine therapy in advanced breast cancer . Negative_regulation PLAU SERPINE1 15061043 1230533 Immunohistochemical staining with tissue derived plasminogen activator ( tPA ) , urokinase derived plasminogen activator ( [uPA] ) , plasminogen activator *inhibitor* ( ) and von Willebrand Factor (vWF) was performed and analyzed with bright field microscopy . Negative_regulation PLAU SERPINE1 15138856 1246932 This article examines the distribution and prognostic importance of urinase type plasminogen activators ( [uPA] ) and of plasminogen activator *inhibitors* ( ) in cases of primary oral squamous cell carcinoma . Negative_regulation PLAU SERPINE1 15183949 1256022 To examine whether urokinase-type plasminogen activator ( [uPA] ) and type 1 plasminogen *inhibitor* ( ) , DNA ploidy , and S-phase fraction (SPF) add supplementary prognostic information relative to stage and Fuhrman 's grade in renal cell carcinoma . Negative_regulation PLAU SERPINE1 15358169 1293373 , the physiological *inhibitor* of tissue-type and [urokinase-type plasminogen activator] , is a unique member of the serpins as it exists in three distinct conformations : an active inhibitory conformation , a non-inhibitory substrate conformation , and a non-reactive latent conformation . Negative_regulation PLAU SERPINE1 15878520 1405983 The central role of the serine protease [urokinase-type plasminogen activator] ( uPA ) and its *inhibitor* , the ( PAI-1 ) , in tumour invasion and metastasis becomes more and more evident . Negative_regulation PLAU SERPINE1 15944795 1416343 The plasminogen activator (PA) system comprises the 2 serine proteases , urokinase PA (uPA) and tissue PA (tPA) , the 2 serpin *inhibitors* , and PAI-2 and the [uPA] receptor ( uPAR ; Negative_regulation PLAU SERPINE1 15970552 1423929 The plasminogen activation system in skeletal muscle regeneration : antagonistic roles of [urokinase-type plasminogen activator] ( uPA ) and its *inhibitor* ( ) . Negative_regulation PLAU SERPINE1 15988036 1429278 Here , we report that prostate carcinoma cells LNCaP and PC3 autoactivate latent full-length PDGF D into its active form under serum independent conditions and that this autoactivation is inhibited by , a [urokinase plasminogen activator (uPA)/tissue] plasminogen activator (tPA) *inhibitor* . Negative_regulation PLAU SERPINE1 16162159 1456146 The rat model of portal branch ligation ( PBL ) was compared with partial hepatectomy ( PH ) and sham operation ( SO ) and evaluated for the expression of heat shock protein-70 ( hsp70 ) , heme oxygenase-1 (hmox1) , early growth response gene-1 (Egr-1) and [urokinase-type plasminogen activator] ( uPA ) , its *inhibitor* ( ) and receptor ( uPAR ) . Negative_regulation PLAU SERPINE1 16289236 1532321 The increased levels of [urokinase-type plasminogen activator] ( uPA ) , uPA-receptor (uPAR) and type-1 PA *inhibitor* ( ) are reported in human renal cell carcinoma (RCC) . Negative_regulation PLAU SERPINE1 16309542 1486636 To verify the applicability of the cell invasion model , multilayer cell constructs of oral squamous cell carcinoma and oral mucosal fibroblasts were exposed to extrinsic [urokinase-type plasminogen activator] ( uPA ) or plasminogen activator *inhibitor* ( ) , which are known effectors of cell migration . Negative_regulation PLAU SERPINE1 16325301 1511720 The complex between urokinase ( [uPA] ) and its type-1 *inhibitor* ( ) in pulmonary adenocarcinoma : relation to prognosis . Negative_regulation PLAU SERPINE1 16491606 1528630 The determination of the protein content of [urokinase-type plasminogen activator] ( uPA ) and its *inhibitor* , , in breast cancer tissue extracts is used clinically to identify patients at risk to experience disease recurrence ( metastasis ) or early death . Negative_regulation PLAU SERPINE1 16611153 1545297 The central components of the PA system are the proteolytic activators , [urokinase-plasminogen activator (u-PA)] and tissue-type plasminogen activator (t-PA) , plasminogen (plg) and its degradation product , plasmin , together with the major *inhibitors* of this system , and -2 ( PAI-1 , PAI-2 ) . Negative_regulation PLAU SERPINE1 16945123 1615515 One of the most thoroughly studied systems in relation to its prognostic relevance in patients with breast cancer , is the plasminogen activation system that comprises of , among others , the [urokinase Plasminogen Activator (uPA)] and its main *inhibitor* , the ( PAI-1 ) . Negative_regulation PLAU SERPINE1 17136335 1653532 Higher levels of [urokinase-type plasminogen activator] ( uPA ) and its *inhibitor* ( ) are linked to the poor prognosis in a variety of malignances . Negative_regulation PLAU SERPINE1 1719003 169483 However , it did not significantly modulate [urokinase-type plasminogen activator] ( u-PA ) , tissue-type plasminogen activator (t-PA) , plasminogen activator *inhibitor* ( ) , and tissue factor ( TF ) . Negative_regulation PLAU SERPINE1 18162327 1883063 The endogenous inhibitors of this system , and PAI-2 , *regulate* [uPA-uPAR] activity by either direct inhibition or affecting cell surface expression and internalization . Negative_regulation PLAU SERPINE1 18193223 1911219 We evaluated the association of impaired DC differentiation with angiogenesis associated molecules D-dimer , vascular endothelial growth factor ( VEGF ) , [urokinase plasminogen activator (uPA)] , and plasminogen activator *inhibitor* ( ) in peripheral blood from 41 patients with lung , breast , and colorectal carcinoma . Negative_regulation PLAU SERPINE1 18472961 1910444 An increase in the expression of , the endogenous [uPA] *inhibitor* , was found during in vitro tumor-stromal interactions . Negative_regulation PLAU SERPINE1 18599586 1959506 H. pylori also stimulated soluble and cell surface bound uPA activity , and both were further increased by PAI-1 knockdown , consistent with *inhibition* of endogenous [uPA] . Negative_regulation PLAU SERPINE1 19082473 2018290 The serine protease [urokinase-type plasminogen activator] ( uPA ) , its receptor ( uPAR ) and its *inhibitor* ( ) are involved in the control of extracellular turnover , cell migration , invasion , cell signalling , proliferation , apoptosis and angiogenesis leading to a variety of different responses , under both physiological and pathological conditions . Negative_regulation PLAU SERPINE1 1919045 168465 The expression of [urokinase-type plasminogen activator] ( u-PA ) and its type-1 *inhibitor* ( ) was examined in vivo in mouse wounds by in situ hybridization and immunohistochemistry . Negative_regulation PLAU SERPINE1 19520712 2116027 The gene expression , protein secretion and activities of the matrix metalloproteinase (MMP)-2 and -9 , [urokinase plasminogen activator (uPA)] , tissue inhibitor of metalloproteinase ( TIMP ) -1 and -2 and plasminogen activator *inhibitor* ( ) of glycodelin-A treated cells were measured by quantitative PCR , ELISA and gel zymography , respectively . Negative_regulation PLAU SERPINE1 19818349 2195994 MDA-MB-231 cells treated with DMC had decreased levels of ECM degradation associated proteins including matrix metalloproteinase-9 (MMP-9) , membrane type-1 matrix metalloproteinase ( MT1-MMP ) , urokinase plasminogen activator (uPA) and uPA receptor (uPAR) , while the level of [uPA] *inhibitor* ( ) was up-regulated . Negative_regulation PLAU SERPINE1 20039121 2248039 [Urokinase-type plasminogen activator] ( uPA ) and its main *inhibitor* ( ) were shown with level 1 evidence to be prognostic factors for primary breast cancer . Negative_regulation PLAU SERPINE1 20204407 2319574 If RNA based multi-gene analyses enter clinical practice , simultaneous determination of currently established markers like human epidermal growth factor receptor 2 ( HER2 ) , [urokinase plasminogen activator (uPA)] and its *inhibitor* ( ) would represent an elegant simplification . Negative_regulation PLAU SERPINE1 20496126 2395186 In the colon , the [urokinase-type plasminogen activator] ( uPA ) , its receptor ( uPAR ) , and plasminogen activator *inhibitors* , and PAI-2 , are implicated in the transition from mucosa to adenoma and tumour progression . Negative_regulation PLAU SERPINE1 20624254 2297086 Serum and induced sputum levels of urokinase-type plasminogen activator ( uPA ) , [urokinase-type plasminogen activator] receptor ( uPAR ) , urokinase-type plasminogen activator *inhibitor* ( ) and human cationic antimicrobial protein 18 ( CAP18 ) were measured by ELISA , in 13 patients with stage I or stage II COPD ( COPD I + II ) , 15 patients with stage III or stage IV COPD ( COPD III + IV ) , 18 healthy non-smokers and 14 healthy smokers . Negative_regulation PLAU SERPINE1 20798546 2324427 In our EVVSS model , the activity as well as the mRNA and protein expression levels of , the *inhibitor* of [urokinase-type plasminogen activator] ( uPA ) and tissue-type plasminogen activator ( tPA ) , were increased after 7 days of perfusion , whereas the expression levels of tPA and uPA were not altered . Negative_regulation PLAU SERPINE1 20823384 2318485 Elevated levels of ( PAI-1 ) , a potent *inhibitor* of [urokinase plasminogen activator] and tissue plasminogen activator , are implicated in the pathogenesis of tissue fibrosis . Negative_regulation PLAU SERPINE1 21199867 2391615 specifically and rapidly *inhibits* [uPA] and tissue-type PA (tPA) . Negative_regulation PLAU SERPINE1 21459526 2422639 The serine protease [urokinase-type plasminogen activator] ( uPA ) and its *inhibitor* ( ) play key roles in the proteolytic cascade involved in physiological and pathological degradation of the extracellular matrix . Negative_regulation PLAU SERPINE1 21465481 2523651 The activities of uPA/tPA/plasmin and plasmin dependent MMPs rely mostly on the activity of a potent *inhibitor* of [uPA/tPA] , ( PAI-1 ) . Negative_regulation PLAU SERPINE1 21465481 2523791 During wound healing , elevated levels of *inhibit* [uPA/tPA/plasmin] and plasmin dependent MMP activities , and , thus , help expedite wound healing . Negative_regulation PLAU SERPINE1 2161846 135835 [uPA] bound to its receptor on human U937 monocyte-like cells was *inhibited* by ( in its active form in the presence of vitronectin fragments ) with an association rate constant of 4.5 x 10 ( 6 ) M-1 s-1 , which was 40 % lower than that obtained for uPA in solution ( 7.9 x 10 ( 6 ) M-1 s-1 ) . Negative_regulation PLAU SERPINE1 21989445 2493479 Prognostic significance of [urokinase-type plasminogen activator] ( uPA ) and plasminogen activator *inhibitor* ( ) in patients with primary invasive ductal breast carcinoma - a 7.5-year follow-up study . Negative_regulation PLAU SERPINE1 21989445 2493483 [Urokinase-type plasminogen activator] ( uPA ) and plasminogen activator *inhibitor* ( ) are key molecules in pericellular proteolysis , a process that plays an important role in tumor invasion and metastasis . Negative_regulation PLAU SERPINE1 2222860 144332 Human non-small lung cancer cell lines HS-24 ( established from a primary squamous cell carcinoma ) and SB-3 ( established from a metastasis of a primary adenocarcinoma of the lung into the adrenal gland ) were analysed for the proteinases tissue-type plasminogen activator ( tPA ) , [urokinase-type plasminogen activator] *inhibitor* ( ) . Negative_regulation PLAU SERPINE1 22445926 2594800 functions to *inhibit* [urokinase type plasminogen activator] ( uPA ) though PAI-1 itself is also implicated in breast cancer progression . Negative_regulation PLAU SERPINE1 22467324 2578607 Expression of [urokinase-type plasminogen activator] ( uPA ) , its receptor ( uPAR ) , and *inhibitor* ( ) in human breast carcinomas and their clinical relevance . Negative_regulation PLAU SERPINE1 23340304 2747430 This study aimed to investigate the potential regulation by ZEB1 of the plasminogen proteolytic system constituted by the [urokinase plasminogen activator (uPA)] , and its *inhibitor* , ( PAI-1 ) . Negative_regulation PLAU SERPINE1 23521527 2799666 ( PAI-1 ) , the serine protease inhibitor ( serpin ) , binds to and *inhibits* the plasminogen activators-tissue-type plasminogen activator ( tPA ) and the [urokinase-type plasminogen activator] ( uPA ) . Negative_regulation PLAU SERPINE1 2363126 136624 The *inhibited* not only [urokinase-type plasminogen activator] ( u-PA ) but single- and two-chain tissue-type plasminogen activators ( t-PAs ) on plasminogen containing fibrin plate . Negative_regulation PLAU SERPINE1 2499321 111901 Corneal epithelial cells secrete tissue plasminogen activator (t-PA) , [urokinase type plasminogen activator] ( u-PA ) and their *inhibitor* ( ) , whereas these cell types in other tissues are known to secrete only u-PA hitherto . Negative_regulation PLAU SERPINE1 25075085 2953929 Clinical significance of urokinase-type plasminogen activator ( [uPA] ) and its type-1 *inhibitor* ( ) for metastatic sentinel lymph node involvement in breast cancer . Negative_regulation PLAU SERPINE1 25075085 2953931 [Urokinase-type plasminogen activator] ( uPA ) and its type-1 *inhibitor* ( ) are key factors for tumor invasion and development of metastases in breast cancer . Negative_regulation PLAU SERPINE1 2514093 123118 ( PAI-1 ) *inhibits* both tissue-type plasminogen activator ( tPA ) and [urokinase-type plasminogen activator] ( uPA ) and , therefore , is an important regulator of plasminogen activation . Negative_regulation PLAU SERPINE1 2544876 114121 We have now investigated whether can bind and *inhibit* receptor bound [uPA] . Negative_regulation PLAU SERPINE1 3104349 71664 We studied the immunocytochemical localization of [urokinase-type plasminogen activator] ( u-PA ) and the type 1 plasminogen activator *inhibitor* ( ) in human fibroblasts and sarcoma cells , using both polyclonal and monoclonal antibodies . Negative_regulation PLAU SERPINE1 3262512 97850 *inhibits* both tissue-type plasminogen activator and [urokinase-type plasminogen activator] and may therefore be implicated in the control of various physiological processes . Negative_regulation PLAU SERPINE1 7586269 333750 Experimental measurements of cardiac output , heart rate , tissue plasminogen activator (TPA) , [urokinase plasminogen activator (UPA)] , plasminogen activator *inhibitor* ( ) , C1-inhibitor , and TPA/C1-inhibitor complex during the infusions and exercise were used to develop a comprehensive fluid-phase model of the circulatory regulation of fibrinolysis . Negative_regulation PLAU SERPINE1 7593235 334628 Message levels of [urokinase-type plasminogen activator] ( u-PA ) and its *inhibitor* ( ) and heat shock protein ( HSP ) -70 are markedly raised 4-8 hours after wounding . Negative_regulation PLAU SERPINE1 7611439 312140 ( PAI-1 ) *inhibited* PA activity of preformed [uPA/uPAR] complexes and increased cycling of the receptor from the cell surface . Negative_regulation PLAU SERPINE1 7738206 305674 ( PAI-1 ) , the primary *inhibitor* of tissue-type plasminogen activator (t-PA) and [urokinase plasminogen activator] , is an important regulator of the blood fibrinolytic system . Negative_regulation PLAU SERPINE1 7929271 274347 The alpha 2-macroglobulin receptor/low density lipoprotein receptor related protein ( alpha 2MR/LRP ) binds several ligands , including complex between the two chain [urokinase-type plasminogen activator] ( uPA ) and type-1 plasminogen activator *inhibitor* ( ) , and the single chain zymogen pro-urokinase ( pro-uPA ) . Negative_regulation PLAU SERPINE1 8062262 268567 We have studied the prognostic value of [urokinase-type plasminogen activator] ( uPA ) , uPA receptor (uPAR) , and type 1 plasminogen activator *inhibitor* ( ) in tumor extracts from 84 patients with squamous cell lung carcinoma and 38 patients with large cell lung carcinoma , measuring each molecule with sandwich enzyme linked immunosorbent assays . Negative_regulation PLAU SERPINE1 8227186 235555 As determined by histopathological methods , the malignant tumors showed statistically significantly higher expression of urokinase plasminogen activator (uPA) , type-1 plasminogen activator *inhibitor* ( ) , and especially [urokinase plasminogen activator] receptor ( uPAR ) than benign tissues . Negative_regulation PLAU SERPINE1 8261432 246653 We have studied the prognostic value of urokinase-type plasminogen activator ( [uPA] ) and type-1 plasminogen activator *inhibitor* ( ) in tumor extracts from 106 patients with adenocarcinoma of the lung . Negative_regulation PLAU SERPINE1 8261450 246686 Active *inhibited* the tumor cell surface receptor bound [uPA] activity . Negative_regulation PLAU SERPINE1 8384415 214756 [Urokinase-type plasminogen activator] ( u-PA ) , its receptor ( u-PAR ) , and type 1 *inhibitor* ( ) in cultured human mesangial cells were investigated . Negative_regulation PLAU SERPINE1 8388317 218248 The prognostic value of [urokinase-type plasminogen activator] ( uPA ) and type 1 plasminogen activator *inhibitor* ( ) levels in cytosolic extracts of ductal breast carcinomas was studied , retrospectively , in 118 premenopausal and 72 postmenopausal high-risk patients entered into the protocol of Danish Breast Cancer Cooperative Group trials for adjuvant treatment of breast cancer . Negative_regulation PLAU SERPINE1 8554169 337124 The [urokinase plasminogen activator (u-PA)] and its *inhibitor* ( ) in embryo-fetal bone formation in the human : an immunohistochemical study . Negative_regulation PLAU SERPINE1 8604004 352326 Anti-uPA monoclonal antibody ( mAb ) suppressed LPS-driven TNF-alpha secretion by 61.6 +/- 5.9 % ( P < .001 ) , and , a [uPA] *inhibitor* , suppressed it to 53.1 +/- 8.2 % of the control value ( P < .001 ) . Negative_regulation PLAU SERPINE1 8624901 354958 To evaluate the role of plasminogen activators ( tPA [uPA] ) and *inhibitor* ( ) in the pathogenesis of preeclampsia . Negative_regulation PLAU SERPINE1 8635858 362113 We have investigated the localization of [urokinase-type plasminogen activator] ( u-PA ) , type-1 plasminogen-activator *inhibitor* ( ) , u-PA receptor (u-PAR) and alpha(2)-macroglobulin- receptor/low-density-lipoprotein-receptor related protein ( alpha ( 2 ) MR/LRP ) in human breast tumors by immunohistochemical methods . Negative_regulation PLAU SERPINE1 8639841 362576 ( PAI-1 ) , a rapid *inhibitor* of both [uPA] and tissue-type plasminogen activator ( tPA ) is the major physiologic regulator of plasminogen activator activity . Negative_regulation PLAU SERPINE1 8703368 371084 The plasminogen and plasmin system , which is mainly regulated by [urokinase-type plasminogen activator] ( uPA ) , its receptor ( uPAR ) and its *inhibitor* ( ) , is generally believed to play a role in cancer invasion and metastasis . Negative_regulation PLAU SERPINE1 8830927 385642 This review focuses on the main components of the fibrinolytic system -- tissue plasminogen activator (tPA) , urokinase ( [uPA] ) and plasminogen activator *inhibitor* ( ) -- and on thrombin . Negative_regulation PLAU SERPINE1 8854251 388067 Using mice with inactivated tissue PA (tPA) , [urokinase PA (uPA)] , or type 1 PA *inhibitor* ( ) genes , we evaluated whether these processes , or their stimulation by parathyroid hormone (PTH) or 1,25-dihydroxyvitamin ( 1,25 [ OH ] 2D3 ) are dependent on these genes . Negative_regulation PLAU SERPINE1 8925884 359048 To clarify the specific expression and regulation of mRNAs for urokinase ( [uPA] ) , its receptor ( uPAR ) , and type-1 plasminogen activator *inhibitor* ( ) , I analyzed RNA from four human cancer cell lines by RNA blotting after treatment with cycloheximide , anisomycin , emetine or puromycin . Negative_regulation PLAU SERPINE1 8959348 401929 Many lines of evidence support an involvement of [urokinase plasminogen activator (uPA)] and its type 1 *inhibitor* ( ) in the migration of a variety of cells , including normal keratinocytes and carcinoma lines . Negative_regulation PLAU SERPINE1 9186598 436873 The plasminogen system , via its triggers , tissue-type plasminogen activator (t-PA) and [urokinase-type plasminogen activator] ( u-PA ) and its *inhibitor* , ( PAI-1 ) , has been implicated in thrombosis , arterial neointima formation , and atherosclerosis . Negative_regulation PLAU SERPINE1 9194591 438170 Evidence has accumulated that [urokinase-type plasminogen activator] ( uPA ) , its *inhibitor* ( ) and receptor ( uPAR ) are involved in tumor invasion and metastasis . Negative_regulation PLAU SERPINE1 9264575 449341 The levels of [plasminogen activator urokinase] ( uPA ) and of its *inhibitor* ( ) were measured by use of ELISA in the cytosol of tissue homogenates obtained from endometrial carcinomas and the marginal , tumor-free endometrium of postmenopausal patients ( n = 64 ) . Negative_regulation PLAU SERPINE1 9272300 450574 To evaluate the effect of therapeutic and pharmacologic concentrations of two non-steroidal anti-inflammatory drugs ( NSAIDs ) , nimesulide and naproxen , on the synthesis of urokinase ( [uPA] ) , plasminogen activator *inhibitor* ( ) and interleukin-6 (IL-6) in human synovial fibroblasts isolated from osteoarthritis ( OA ) patients . Negative_regulation PLAU SERPINE1 9414430 408189 We therefore investigated the inhibitory effect of TNP-470 on cancer cell proliferation , and the suppressive effect of TNP-470 on [urokinase-type plasminogen activator] ( u-PA ) and its *inhibitor* ( ) , in human lung cancer cell lines in vitro . Negative_regulation PLAU SERPINE1 9743288 532340 There was no significant relationship between either of the nm23 isoforms and cathepsin D (Cat-D) , [urokinase plasminogen activator (uPA)] , its *inhibitor* ( ) , steroid hormone receptors or ploidy status . Negative_regulation PLAU SERPINE1 9815678 479515 We have reported previously that both [urokinase-type plasminogen activator] ( uPA ) and its type 1 *inhibitor* ( ) are statistically significant prognostic variables in patients with high-risk breast cancer ( Grondahl-Hansen et al. , Cancer Res. , 53 : 2513-2521 , 1993 ) , and we recently described that the uPA receptor (uPAR) is a prognostic marker in postmenopausal , node positive breast cancer patients ( Grondahl-Hansen et al. , Clin . Negative_regulation PLAU SERPINE1 9815897 345397 We have recently described the [urokinase-type plasminogen activator] ( uPA ) and its type 1 *inhibitor* ( ) as strong prognostic variables in breast cancer ( J. A. Foekens et al. , Cancer Res. , 52 : 6101-6105 , 1992 ; Negative_regulation PLAU SERPINE1 9836475 552197 External quality assessment of trans-European multicentre antigen determinations ( enzyme linked immunosorbent assay ) of [urokinase-type plasminogen activator] ( uPA ) and its type 1 *inhibitor* ( ) in human breast cancer tissue extracts . Negative_regulation PLAU SERPINE2 20736374 2313454 [Urokinase plasminogen activator (uPA)] is *inhibited* by . Negative_regulation PLAU SMAD3 21798735 2605054 In the present study , we analysed the *role* of TGF-ß1 induced activation in the [urokinase type plasminogen activator] ( uPA ) production , as well as in cell migration and E-cadherin downregulation in transformed PDV keratinocyte cell line . Negative_regulation PLAU SMAD4 16959768 1639572 *dependent* regulation of [urokinase plasminogen activator] secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-beta . Negative_regulation PLAU SPHK1 19147534 2026257 Inhibition of *blocked* basal expression of [uPA] and uPAR , as well as glioma cell invasion ; Negative_regulation PLAU SPHK1 19147534 2026261 however , overexpression of did not *augment* S1P receptor mediated enhancement of [uPA] activity or invasion . Negative_regulation PLAU SPHK2 19147534 2026258 Inhibition of *blocked* basal expression of [uPA] and uPAR , as well as glioma cell invasion ; Negative_regulation PLAU SPHK2 19147534 2026262 however , overexpression of did not *augment* S1P receptor mediated enhancement of [uPA] activity or invasion . Negative_regulation PLAU SPINK7 19796867 2209130 In this study , we found that *inhibits* proteolysis activity of [uPA/plasmin] and MMP2 , and substantially reduces the ability of HT1080 and HCT-116 cells to invade ECM . Negative_regulation PLAU SPINK7 19796867 2209135 Conversely , depletion of not only markedly *increased* proteolysis activity of [uPA/plasmin] and MMP2 but also enhanced the association of uPAR with FPRL1 , stimulated cell migration/invasion . Negative_regulation PLAU SPRED2 19908229 2247799 *inhibits* TGF-beta1 induced [urokinase type plasminogen activator] expression , cell motility and epithelial mesenchymal transition . Negative_regulation PLAU SPRED2 19908229 2247802 In the present work , we analyzed the *role* of in the [urokinase-type plasminogen activator] ( uPA ) stimulation , EMT and cell migration by TGF-beta1 . Negative_regulation PLAU SRC 10471383 641775 Furthermore , expression of either FRNK , a kinase-minus FAK-like molecule acting as a dominant negative FAK , or a dominant negative *suppressed* CSR induced [uPA] gene promoter activation . Negative_regulation PLAU SYK 12477728 1056084 , a protein-tyrosine kinase , *suppresses* the cell motility and nuclear factor kappa B-mediated secretion of [urokinase type plasminogen activator] by inhibiting the phosphatidylinositol 3'-kinase activity in breast cancer cells . Negative_regulation PLAU SYK 12477728 1056095 To our knowledge , this is the first report that suppresses the cell motility and *inhibits* the PI 3'-kinase activity and [uPA] secretion by blocking NF kappa B activity through tyrosine phosphorylation of I kappa B alpha . Negative_regulation PLAU SYK 16474166 1548356 Moreover , and Lck play differential roles in regulating Sp1 activation and expressions of melanoma cell adhesion molecule (MelCAM) , urokinase-type plasminogen activator ( uPA ) , matrix metalloproteinase-9 (MMP-9) , and vascular endothelial growth factor ( VEGF ) in response to H/R. Overexpression of wild type Syk *inhibited* the H/R induced [uPA] , MMP-9 , and VEGF expression but up-regulated MelCAM expression . Negative_regulation PLAU TANK 23392805 2739932 Overexpression of or Bcl-xL strongly *increased* TRAIL mediated upregulation of [uPA] and IL-8 . Negative_regulation PLAU TEC 9095328 422335 Both AGM-1470 and *inhibited* the production of [urokinase-type plasminogen activator] ( u-PA ) , an enzyme involved in the early steps of neovascularization . Negative_regulation PLAU TGFB1 14597403 1160621 In contrast , *triggered* a large decrease of uPA and tPA , as well as a decrease of [uPA] and uPAR mRNAs . Negative_regulation PLAU TGFB1 1481722 208213 *inhibited* IL-1 beta stimulated [uPA] activity , but the effect on tPA was more variable . Negative_regulation PLAU TGFB1 15201140 1288926 The p38 MAPK inhibitor SB203580 reversed the *dependent* inhibition of [uPA] activity but not its morphogenetic effect . Negative_regulation PLAU TGFB1 8618030 359327 Fibrin gel degradation occurred through plasmin mediated fibrinolysis , which was initiated by fibroblasts exhibited high [uPA] but low plasminogen activator inhibitor-1 ( PAI-1 ) activities , and *prevented* fibrinolysis of normal fibroblasts by upregulating PAI-1 while downregulating uPA activities . Negative_regulation PLAU TGFB1 8892973 392264 The bFGF induced increase in [uPA] activity was *inhibited* in a dose dependent manner by hydrocortisone and ( TGF-beta1 ) . Negative_regulation PLAU TGFB1 9076959 420382 *reduced* the level of [urokinase plasminogen activator] and stimulated the secretion of plasminogen activator inhibitor-1 and progelatinase B in both neonatal and fetal fibroblasts . Negative_regulation PLAU TGFB1 9472634 486279 In HBECs , *inhibited* cell proliferation and [uPA] activity , while it augmented plasminogen activator inhibitor-1 ( PAI-1 ) antigen level . Negative_regulation PLAU TGFB1I1 18812162 1976282 In addition , reduced cells migration into three-dimensional collagen gels , and the forced expression of Hic-5 in cells embedded in the collagen gel matrix *repressed* the expression of [uPA] that participates in smooth muscle cell migration . Negative_regulation PLAU THBS1 1309073 209128 also slowly *inhibits* [urokinase plasminogen activator] . Negative_regulation PLAU THBS1 1531022 180266 also *inhibits* [urokinase plasminogen activator] , but more slowly than plasmin , stimulates the amidolytic activity of tissue plasminogen activator , and has no effect on the amidolytic activity of alpha-thrombin or factor Xa . Negative_regulation PLAU TIMP1 11205273 763522 High levels of and PAI1 present in S variant *reduce* MMP9 and [uPA] activities , respectively . Negative_regulation PLAU TIMP1 11468515 840890 All the tumours expressed matrix metalloproteinases (MMP)-2 and-9 , tissue *inhibitor* of metalloproteases ( ) -2 , [urokinase plasminogen activator (u-PA)] , plasminogen activator inhibitor (PAI)-1 and PAI-2 . Negative_regulation PLAU TIMP1 12093135 960217 Northern blot analysis demonstrated that genes encoding [urokinase type plasminogen activator] ( uPA ) , urokinase type plasminogen activator receptor ( uPAR ) , plasminogen activator inhibitor-1 ( PAI-1 ) , tissue *inhibitor* of metalloproteinases ( ) and c- myc were up-regulated in response to hyaluronan . Negative_regulation PLAU TIMP1 12376281 996740 Expression of matrix metallsoproteinase (MMP)-2 , MMP-9 , tissue *inhibitor* of metalloproteinases ( ) -1 and [urokinase-type plasminogen activator] ( u-PA ) , other than that of TIMP-2 and plasminogen activator inhibitor type ( PAI ) -1 , was observed in normal trophoblastic cells in in vitro culture . Negative_regulation PLAU TIMP1 1317222 187903 To investigate the role of tumor necrosis factor-alpha (TNF alpha) in advanced collagenolysis and degradation of connective tissue components in preterm parturition , the effects of human recombinant TNF alpha ( hrTNF alpha ) on the production of matrix metalloproteinase 1 (MMP-1)/tissue collagenase , MMP-3/stromelysin , tissue *inhibitor* of metalloproteinases ( ) , [urokinase type-plasminogen activator] ( uPa ) and prostaglandin ( PG ) E2 in human chorionic cells were examined in vitro . Negative_regulation PLAU TIMP1 1679130 164819 They induce fibroblasts and macrophages to produce neutral metalloproteinases such as procollagenase and prostromelysin , the serine proteinase [urokinase-type plasminogen activator] ( u-PA ) , tissue *inhibitor* of metalloproteinase ( ) , and prostaglandins , u-PA converts plasminogen into plasmin , which can activate neutral metalloproteinase proenzymes , and these enzymes degrade the extracellular matrix components . Negative_regulation PLAU TIMP1 18824345 2113755 ISL decreased EGF induced secretion of [urokinase-type plasminogen activator] ( uPA ) , matrix metalloproteinase (MMP)-9 , tissue *inhibitor* of metalloproteinase-1 ( ) , and vascular endothelial growth factor ( VEGF ) , but increased TIMP-2 secretion in a concentration dependent manner . Negative_regulation PLAU TIMP1 19945964 2190643 Vascular endothelial growth factor-A ( VEGF-A ) , [urokinase plasminogen activator (uPA)] , matrix metalloproteinase-3 (MMP-3) and their *inhibitors* including thrombospondin-1 , plasminogen activator inhibitor-1 and MMP inhibitor type 1 ( ) mRNA levels were evaluated by quantitative RT-PCR , and protein levels were quantified by ELISA . Negative_regulation PLAU TIMP1 21170677 2480051 BITC induced a significant reduction in the levels of matrix metalloproteinase (MMP)-2 , MMP-9 , tissue *inhibitor* of metalloproteinase ( ) -1 , and [urokinase-type plasminogen activator] in the sera and lungs of 4T1 cell injected mice . Negative_regulation PLAU TIMP1 23560439 2777948 The MMP-9 activity was suppressed by these compounds through regulating [urokinase-type plasminogen activator] ( uPA ) , tissue *inhibitor* of metalloproteinase ( ) -1 , plasminogen activator inhibitor (PAI)-1 , and PAI-2 ; Negative_regulation PLAU TIMP1 9263524 449194 In order to clarify the role of matrix metalloproteinase-9 (MMP-9) , [urokinase-type plasminogen activator] ( uPA ) and tissue *inhibitor* of metalloproteinase ( ) in metastases of gastroenterological cancer , their gene expression in the primary lesions on 47 gastric or 48 colorectal cancer patients was examined by RT-PCR method . Negative_regulation PLAU TIMP2 15520187 1329008 Here we found that the expression of epiregulin , [urokinase-type plasminogen activator] ( uPA ) , matrix metalloproteinase (MMP)14 , and tissue *inhibitor* of metalloproteinase ( ) were consistently and progressively up-regulated when viewed as a function of tumor stage in tissues of patients versus the metastatic potential seen in the mouse lung model . Negative_regulation PLAU TIMP2 16387334 1567070 Moreover , berberine also exerted its action via regulating tissue inhibitor of metalloproteinase-2 ( ) and [urokinase-plasminogen activator] *inhibitor* ( PAI ) . Negative_regulation PLAU TIMP2 18495463 2019771 In this line , we comparatively examined the influence of Cur , DMC and BDMC on the expressions of [uPA] , MMP-2 , MMP-9 , membrane Type 1 MMP (MT1-MMP) , tissue *inhibitor* of metalloproteinases ( ) , and in vitro invasiveness of human fibrosarcoma cells . Negative_regulation PLAU TIMP3 12890575 1117650 However , the mRNAs coding for [urokinase type PA (uPA)] , membrane-type 1 MMP (MT1-MMP) , and tissue *inhibitor* of metalloproteinases type-3 ( ) were constantly expressed in the mouse CL throughout its whole life span . Negative_regulation PLAU TNF 10892857 711303 Both IL-1beta and *induced* a significant decrease in [uPA] expression in PBF , whereas bFGF induced a slight increase in both HJF and PBF . Negative_regulation PLAU TNF 12236587 989108 Treatment of Beas2B cells with NaF inhibited *mediated* translocation of uPA mRNABp from the cytoplasm to the nucleus and concomitant inhibition of [uPA] expression . Negative_regulation PLAU TNF 1338337 209132 and LPS *inhibited* both CSF-1 stimulated [urokinase-type plasminogen activator] ( u-PA ) mRNA levels and u-PA activity in BMM , whereas IFN gamma lowered only the u-PA activity . Negative_regulation PLAU TNF 21112094 2372186 *increased* EVT apoptosis , decreased villous cytotrophoblast proliferation and increased expression of pro-MMP-9 ( but not active MMP-9 ) , [urokinase plasminogen activator (uPA)] and plasminogen activator inhibitor (PAI)-1 by EVT . Negative_regulation PLAU TNFAIP8L2 24274578 2876817 Mechanically , inhibits the migration and invasion through targeting Rac1 and then *reduces* F-actin polymerization and expression of matrix metallopeptidase 9 (MMP9) and [urokinase plasminogen activator (uPA)] . Negative_regulation PLAU TP53 22140072 2557865 We therefore sought to determine whether mediated *inhibition* of [urokinase-type plasminogen activator] ( uPA ) and induction of plasminogen activator inhibitor-1 ( PAI-1 ) contribute to ATII cell apoptosis that precedes the development of PF . Negative_regulation PLAU TP53 22140072 2557872 Thus is increased and *inhibits* expression of [uPA] and uPAR while increasing PAI-1 , changes that promote ATII cell apoptosis in mice with BLM induced ALI . Negative_regulation PLAU VEGFA 16474166 1548357 Moreover , Syk and Lck play differential roles in regulating Sp1 activation and expressions of melanoma cell adhesion molecule (MelCAM) , urokinase-type plasminogen activator ( uPA ) , matrix metalloproteinase-9 (MMP-9) , and vascular endothelial growth factor ( ) in response to H/R. Overexpression of wild type Syk *inhibited* the H/R induced [uPA] , MMP-9 , and VEGF expression but up-regulated MelCAM expression . Negative_regulation PLAU VEGFA 19693769 2150957 Our results , therefore , suggest that B-DIM down-regulates [uPA-uPAR] in aggressive breast cancers but in the absence of uPA-uPAR , B-DIM can directly *inhibit* and MMP-9 leading to the inhibition of cell growth and migration of breast cancer cells . Negative_regulation PLAU VTN 21316840 2398831 Herein we show that PAI-2 is capable of inhibiting [uPA] in the presence of PAI-1 , particularly on adherent cells in the *presence* of . Negative_regulation PLAU VTN 9164658 406992 These data demonstrate that the synthesis of and its matrix association by transfected HT-1080 fibrosarcoma cells *results* in localization of [uPA] to alpha v beta 5 containing focal adhesions , decreased cell surface uPA activity , and an increase in cell adhesion . Negative_regulation PLAU YBX1 19430491 2096417 Similarly , silencing *suppressed* invasion and [uPA] production however this was reversible through the introduction of constitutively active PIK3CA . Negative_regulation PLAUR EPHB2 18762175 1975470 Inhibition of PKC-and *resulted* in a strong down-regulation of basal [uPAR] expression whereas the FFA induced up-regulation remained unchanged . Negative_regulation PLAUR EPHB2 22221673 2686246 We also showed that pathway activation was *involved* in the regulation of [uPAR] gene expression in SMCs . Negative_regulation PLAUR ITGAL 9600959 506496 To investigate the mechanism ( s ) of this induction , we used the RNA polymerase II inhibitor 5 , 6-dichloro-1-beta-D-ribobenzimidazole and determined that [uPAR] mRNA degradation is *delayed* by activation . Negative_regulation PLAUR MAP2K6 20089873 2258682 In addition , the VEGF induced transcriptional *activation* of beta-catenin and [uPAR] expression were blocked by PEDF and by inhibitors of p38 and . Negative_regulation PLAUR MAP2K6 22221673 2686252 We also showed that pathway activation was *involved* in the regulation of [uPAR] gene expression in SMCs . Negative_regulation PLAUR PLAU 10766865 684640 We also demonstrated that SB203580 induced reduction in [uPA/uPAR] mRNA expression *resulted* from the de- stabilization of and uPAR mRNA . Negative_regulation PLAUR PLAU 17134505 1661451 Absence of [uPAR] alone or the combined absence of uPAR and tPA had no impact on the resolution of centrilobular injury , but the loss of receptor-free significantly *impaired* the clearance of necrotic hepatocytes up to 14 days after CCl4 . Negative_regulation PLAUR PLAU 19029002 2029306 To determine the *role* of in [uPAR] expression during ALI caused by sepsis . Negative_regulation PLAUR PLAU 19330806 2080416 Moreover , we found that uPA as well as [uPAR] induced the production of VEGF and MMP-9 , and that the down-regulation of by siRNAs or B-DIM treatment *resulted* in the inhibition of VEGF and MMP-9 secretion which could be responsible for the observed inhibition of cell migration . Negative_regulation PLAUR PLAU 8830783 385623 Taken together , these results suggest a dynamic regulatory *role* for PAI-1 and in [uPAR] mediated cell adhesion and release . Negative_regulation PLAUR SELL 11290756 800670 To examine the *role* of in [uPAR] mediated signaling , uPAR was cross linked and intracellular Ca ( 2+ ) concentrations were measured by spectrofluorometry . Negative_regulation PLAUR SPHK1 19147534 2026259 Inhibition of *blocked* basal expression of uPA and [uPAR] , as well as glioma cell invasion ; Negative_regulation PLAUR TNF 9609725 511064 Phorbol 12-myristate 13-acetate , lipopolysaccharide , transforming growth factor-beta , , or cycloheximide induced uPAR and uPAR mRNA expression in cultured rabbit pleural mesothelial cells and lung fibroblasts and concurrently *reduced* the [uPAR] mRNA-uPAR mRNABP interaction . Negative_regulation PLB1 MAP2K6 10855690 704356 Overexpression of ( mitogen activated protein [ MAP ] kinase kinase ) , which is known to stimulate phosphorylation of NF-IL6 , induced a 3.6-fold *increase* in [hPL-B] enhancer activity . Negative_regulation PLCG1 EPHB2 17524370 1762099 HSV mediated overexpression of [PLCgamma1] in PC12 cells *induced* activation via a mechanism dependent , in part , on both MAP-ERK kinase (MEK) and protein kinase C . PLCgamma1 overexpression in the VTA similarly induced ERK activation in the VTA in vivo . Negative_regulation PLCG1 ITGAL 19542227 2116372 Using membrane vesicles expressing the mouse class I major histocompatibility complex , i.e. Ld plus costimulatory ligands , i.e . B7-1 and intercellular adhesion molecule-1 along with 2C T cell receptor transgenic T cells , we investigated the *roles* of CD28 and ( lymphocyte function associated antigen-1 ) in the activation of [PLC-gamma1] and Ca2+ signaling . Negative_regulation PLD1 EPHB2 16253958 1501792 Finally , pharmacological inhibition of activation and the *inhibition* of [PLD] expression by antisense oligonucleotides in HL-60 cells suggest that the ERK/PLD2 pathway contributes to fMLP mediated oxidant production . Negative_regulation PLD1 FAS 10395739 627552 cross linking *resulted* in a both dose- and time dependent increases in [phospholipase D] activity . Negative_regulation PLD1 FAS 10799296 691056 We have previously reported that cross linking *resulted* in an increase in [phospholipase D] activity in A20 murine cells ( J.-S . Negative_regulation PLD1 FAS 11007187 735350 We have previously reported that cross linking *resulted* in the activation of phosphatidylcholine-specific phospholipase C ( PC-PLC ) and the subsequent activation of protein kinase C ( PKC ) and [phospholipase D (PLD)] in A20 cells . Negative_regulation PLD1 IL1B 10919268 717204 NG-methyl-L-arginine ( LMA ) , a blocker of the inducible form of nitric oxide synthase ( iNOS ) , prevented this late inhibitory effect of IL-1beta , suggesting that *induced* decrease in [PLD1a] expression is NO-mediated . Negative_regulation PLD2 EPHB2 16253958 1501793 Finally , pharmacological inhibition of activation and the *inhibition* of [PLD] expression by antisense oligonucleotides in HL-60 cells suggest that the ERK/PLD2 pathway contributes to fMLP mediated oxidant production . Negative_regulation PLD2 FAS 10395739 627553 cross linking *resulted* in a both dose- and time dependent increases in [phospholipase D] activity . Negative_regulation PLD2 FAS 10799296 691057 We have previously reported that cross linking *resulted* in an increase in [phospholipase D] activity in A20 murine cells ( J.-S . Negative_regulation PLD2 FAS 11007187 735351 We have previously reported that cross linking *resulted* in the activation of phosphatidylcholine-specific phospholipase C ( PC-PLC ) and the subsequent activation of protein kinase C ( PKC ) and [phospholipase D (PLD)] in A20 cells . Negative_regulation PLD2 MAP2K6 15226317 1289297 Furthermore , PLD2 was activated by MEK-CA , whereas NGF stimulated [PLD2] *activation* and hypertrophic neurite extension were blocked by an inhibitor . Negative_regulation PLD2 MAP2K6 21893037 2486958 Overexpression of constitutively active ( MKK6-CA ) *activated* coexpressed [PLD2] in PC12 and mouse neuroblastoma N1E-115 cells . Negative_regulation PLD3 EPHB2 16253958 1501788 Finally , pharmacological inhibition of activation and the *inhibition* of [PLD] expression by antisense oligonucleotides in HL-60 cells suggest that the ERK/PLD2 pathway contributes to fMLP mediated oxidant production . Negative_regulation PLD3 FAS 10395739 627548 cross linking *resulted* in a both dose- and time dependent increases in [phospholipase D] activity . Negative_regulation PLD3 FAS 10799296 691052 We have previously reported that cross linking *resulted* in an increase in [phospholipase D] activity in A20 murine cells ( J.-S . Negative_regulation PLD3 FAS 11007187 735345 We have previously reported that cross linking *resulted* in the activation of phosphatidylcholine-specific phospholipase C ( PC-PLC ) and the subsequent activation of protein kinase C ( PKC ) and [phospholipase D (PLD)] in A20 cells . Negative_regulation PLD4 EPHB2 16253958 1501789 Finally , pharmacological inhibition of activation and the *inhibition* of [PLD] expression by antisense oligonucleotides in HL-60 cells suggest that the ERK/PLD2 pathway contributes to fMLP mediated oxidant production . Negative_regulation PLD4 FAS 10395739 627549 cross linking *resulted* in a both dose- and time dependent increases in [phospholipase D] activity . Negative_regulation PLD4 FAS 10799296 691053 We have previously reported that cross linking *resulted* in an increase in [phospholipase D] activity in A20 murine cells ( J.-S . Negative_regulation PLD4 FAS 11007187 735346 We have previously reported that cross linking *resulted* in the activation of phosphatidylcholine-specific phospholipase C ( PC-PLC ) and the subsequent activation of protein kinase C ( PKC ) and [phospholipase D (PLD)] in A20 cells . Negative_regulation PLD5 EPHB2 16253958 1501790 Finally , pharmacological inhibition of activation and the *inhibition* of [PLD] expression by antisense oligonucleotides in HL-60 cells suggest that the ERK/PLD2 pathway contributes to fMLP mediated oxidant production . Negative_regulation PLD5 FAS 10395739 627550 cross linking *resulted* in a both dose- and time dependent increases in [phospholipase D] activity . Negative_regulation PLD5 FAS 10799296 691054 We have previously reported that cross linking *resulted* in an increase in [phospholipase D] activity in A20 murine cells ( J.-S . Negative_regulation PLD5 FAS 11007187 735347 We have previously reported that cross linking *resulted* in the activation of phosphatidylcholine-specific phospholipase C ( PC-PLC ) and the subsequent activation of protein kinase C ( PKC ) and [phospholipase D (PLD)] in A20 cells . Negative_regulation PLD6 EPHB2 16253958 1501791 Finally , pharmacological inhibition of activation and the *inhibition* of [PLD] expression by antisense oligonucleotides in HL-60 cells suggest that the ERK/PLD2 pathway contributes to fMLP mediated oxidant production . Negative_regulation PLD6 FAS 10395739 627551 cross linking *resulted* in a both dose- and time dependent increases in [phospholipase D] activity . Negative_regulation PLD6 FAS 10799296 691055 We have previously reported that cross linking *resulted* in an increase in [phospholipase D] activity in A20 murine cells ( J.-S . Negative_regulation PLD6 FAS 11007187 735348 We have previously reported that cross linking *resulted* in the activation of phosphatidylcholine-specific phospholipase C ( PC-PLC ) and the subsequent activation of protein kinase C ( PKC ) and [phospholipase D (PLD)] in A20 cells . Negative_regulation PLG A2ML1 23407400 2793838 Addition of anti-A2ML1 polyclonal antibody to culture media decreased NHK cell adhesion examined by dissociation assay , and increased plasmin activity detected by casein zymography , suggesting that anti-A2ML1 antibody may decrease NHK cell adhesion through [plasmin] *activation* by inhibition of . Negative_regulation PLG F2R 16055357 1453982 32D TPO cells expressed Mk-specific markers by FACS ( CD41 , CD61 and 2D5 ) and RT-PCR ( acetyl cholinesterase E and platelet factor 4 ) and their unique profile , by gene array analysis , included expression of urokinase plasminogen activator surface receptor ( CD87 or uPAR ) , [plasminogen] activator *inhibitor* and coagulation factor II (thrombin) receptor ( ) . Negative_regulation PLG F3 21675259 2442941 Eleven polymorphisms in 7 genes coding hemostasis protein synthesis were investigated : V Leiden G1691A factor , G20210A prothrombin , C677T methylentetrahydrofolatreductase , A1298C methylentetrahydrofolatreductase , type 1 [plasminogen] activator *inhibitor* , 4G/5G promoter region , XIII V34L , IIIa L33P thrombocytic glycoprotein , C282Y hemochromatosis , G854A beta-fibrinogen , G455A beta-fibrinogen , C249T beta-fibrinogen . Negative_regulation PLG F3 24410816 2907081 Blood samples were collected within 12 hours of the traumatic incident for measurement of blood gases , lactate concentration , platelet count , activated clotting time , prothrombin time , activated partial time ( aPTT ) , fibrinogen concentration , antithrombin activity , D-dimer concentration , protein C activity , [plasmin] *inhibition* , plasminogen activity , and kaolin activated thomboelastography . Negative_regulation PLG FUT4 8437554 213131 at 2 .67 x 10 ( -7 ) M in vitro can *inhibit* only thrombin and [plasmin] at nearly 50 % , and can not inhibit platelet aggregation and collagenase directly . Negative_regulation PLG GAB3 7890006 299176 These results show that *suppresses* [plasmin] generation and following D-dimer production more effectively than thrombin generation after hepatic resection . Negative_regulation PLG MMP28 17574041 1754373 Migration assays were performed in the presence of K with and without the [plasmin] *inhibitors* ( aprotinin and -aminocaproic acid ) , the Galphai inhibitor Pertussis toxin , the inhibitor ( GM6001 ) , the PI3-K inhibitors , Wortmannin and LY294002 , and the MAPK inhibitors PD98089 ( MEK1 inhibitor ) and SB203580 ( p38 ( MAPK ) inhibitor ) . Negative_regulation PLG MMP7 17574041 1754401 Migration assays were performed in the presence of K with and without the [plasmin] *inhibitors* ( aprotinin and -aminocaproic acid ) , the Galphai inhibitor Pertussis toxin , the inhibitor ( GM6001 ) , the PI3-K inhibitors , Wortmannin and LY294002 , and the MAPK inhibitors PD98089 ( MEK1 inhibitor ) and SB203580 ( p38 ( MAPK ) inhibitor ) . Negative_regulation PLG NEDD9 11489354 845299 We verified the regulation of protooncogene cot , XMP , and human ( HEF1 ) , genes involved in cellular proliferation , as well as metallothionein , [plasminogen] activator *inhibitor* ( PAI1 ) , and HM74 , genes involved in cellular signaling and regeneration . Negative_regulation PLG PLAT 10974336 729297 Parallel *increases* in tissue [plasminogen] activity and antigen with a concomitant decrease in inhibitor-1 activity were also observed after exercise . Negative_regulation PLG PLAT 11273882 797544 Human peritoneal mesothelial cells ( HMCs ) have a critical role in maintaining the intraperitoneal balance between fibrinolysis and coagulation by expressing the fibrinolytic enzyme , ( tPA ) , as well as a specific [plasminogen] activator *inhibitor* ( type 1 ; Negative_regulation PLG PLAT 11275731 797853 They secrete , urokinase-type plasminogen activator ( u-PA ) , [plasminogen] activator *inhibitors* ( PAI-1 and PAI-2 ) , and express u-PA receptors ( u-PAR/CD87 ) at their surface . Negative_regulation PLG PLAT 11775254 766383 The plasma level of platelet alpha-granular membrane protein-140 , soluble fibrinomonomer complex , thrombomodulin , and D-dimer significantly *increased* , fibrinogen , antigen level of protein C , plasminogen , alpha [2-plasminogen] inhibitor and plasminogen activator inhibitor decreased at diagnosis , were restored to normal after complete remission but protein C activity and protein S remained elevated in ATRA group . Negative_regulation PLG PLAT 11797019 892454 After blood sampling we measured activation markers of fibrinolysis [ plasmin/alpha(2)-antiplasmin complexes ( PAP ) , complexes of tissue plasminogen [activator/plasminogen] activator *inhibitor* ( ) , fibrin(ogen) degradation products ( FDPs ) , D-dimmers fibrin degradation products ( D-d ) ] , the utilization marker of antithrombin III (ATIII) thrombin/antithrombin complexes (TAT) , several factors of fibrinolysis [ plasminogen , tissue plasminogen activator (tPA) , plasminogen activator inhibitor 1 ( PAI-1 ) , alpha(2)-antiplasmin ] , and the natural coagulation inhibitors [ ATIII , protein C (PrC) , protein S (PrS) ] . Negative_regulation PLG PLAT 11929177 927236 We measured plasma levels of thrombin antithrombin III complex (TAT) , fibrinopeptide A ( FPA ) , tissue plasminogen [activator-plasminogen] activator *inhibitor* ( ) : markers of coagulation-fibrinolysis-system , and also beta-thromboglobulin ( beta-TG ) : a marker of platelet activation , in 40 COPD patients and in 20 control subjects . Negative_regulation PLG PLAT 15060421 1230518 We compared fibrinolytic parameters <[tissue-type plasminogen activator> ( t-PA ) , [plasminogen] activator *inhibitor* ( PAI-1 ) , euglobulin clot lysis time ] measured in the femoral vein with those in the right atrium . Negative_regulation PLG PLAT 15522965 1335675 This effect of deficiency was not *mediated* by [plasminogen] , because plasminogen-deficient mice demonstrated normal behavioral and hormonal changes to CRF . Negative_regulation PLG PLAT 17181930 1662659 Plasma [plasminogen] activator *inhibitor* ( PAI-1 ) , antigens ( Ag ) and high sensitive C-reactive protein ( hs-CRP ) levels were measured during low salt intake at baseline . Negative_regulation PLG PLAT 17243913 1690731 Multiple regression analysis revealed several independent associations between , [plasminogen] activator *inhibitor* , body mass index and lipid levels , describing up to 40 % of the variance in fibrinolytic variables . Negative_regulation PLG PLAT 1737024 181845 An amount of PIXI which inhibited by 50 % factor XIa cleavage of the chromogenic substrate S2366 ( Pyr-Glu-Pro-Arg-pNA-2H2O ) only slightly inhibited ( 5-9 % ) factor XIIa , plasma kallikrein , [plasmin] , and activated protein C and did not *inhibit* factor Xa , thrombin , , or trypsin , suggesting specificity for factor XIa . Negative_regulation PLG PLAT 1904779 159426 Fifty-six pregnant women ( gestational age 6-40 weeks ) were evaluated for their coagulation activation ( fibrin monomers and thrombin-antithrombin III complex ) and for their fibrinolysis profile by determining , [plasminogen] activator *inhibitor* , plasminogen , alpha 2-antiplasmin and D-dimer . Negative_regulation PLG PLAT 19222708 2050256 Thus , neuroserpin inhibition of activity *leads* to reduced [plasmin] and may be responsible for reduced clearance of amyloid-beta in the Alzheimer disease brain . Negative_regulation PLG PLAT 19621739 1358652 We were especially interested in the study of the changing fibrinolytic system parameters such as , [plasminogen] activator *inhibitor* ( PAI-1 ) , plasminogen , alpha2-antiplasmin activities . Negative_regulation PLG PLAT 20160640 2227793 The fibrinolytic activity of blood is regulated by expressing and its specific inhibitor , type-1 [plasminogen] activator *inhibitor* ( PAI-1 ) , from vascular endothelial cells . Negative_regulation PLG PLAT 2143947 140041 Transplacental effect of lead compounds on activity , [plasminogen] activator *inhibition* and plasmin inhibition . Negative_regulation PLG PLAT 2147015 144094 Effect of orchidectomy on activity , [plasminogen] activator *inhibition* and plasmin inhibition . Negative_regulation PLG PLAT 2349543 135104 Variable effect of unilateral or bilateral ovariectomy performed in young or adult animals on activity , plasminogen activator inhibition and [plasmin] *inhibition* . Negative_regulation PLG PLAT 24036060 2857157 Inhibition of activity *leads* to reduced brain levels of [plasmin] , one of the main enzymes responsible for the degradation and clearance of amyloid-beta and its plaques from the brain . Negative_regulation PLG PLAT 2532794 123250 The effect of experimental chronic hypertension on activity , [plasminogen] activator *inhibition* and plasmin inhibition . Negative_regulation PLG PLAT 3146134 102044 In this study , the importance of anthropometric , nutritional and endocrine variables on the plasma concentrations of tissue plasminogen activator antigen ( ) and [plasminogen] activator *inhibitor* ( PAI-l ) were investigated . Negative_regulation PLG PLAT 6448164 11967 The effect of the anabolic steroid stanozolol on activity and [plasmin] *inhibition* in the rat . Negative_regulation PLG PLAT 7607578 311846 Circadian variations of plasminogen activator activity , antigen , [plasminogen] activator *inhibition* and plasmin inhibition in rat aorta , heart and brain are influenced by endotoxin or aspirin or endotoxin plus aspirin . Negative_regulation PLG PLAT 7769094 308487 *inhibits* [plasmin] degradation of fibrin . Negative_regulation PLG PLAT 7952409 277545 Samples were assayed for coagulation factors ( fibrinopeptide A , antithrombin III , protein C ) , fibrinolytic factors <[tissue-type plasminogen activator> ( t-PA ) , alpha 2 antiplasmin , [plasminogen] activator *inhibitor* ( PAI-1 ) ] and markers of platelet activation ( platelet factor 4 , beta thromboglobulin ) . Negative_regulation PLG PLAT 8264050 239272 The balance between the EC-derived fibrinolytic components , plasminogen activator ( ) , and [plasminogen] *inhibitor* ( PAI-1 ) contributes to maintaining thromboresistance . Negative_regulation PLG PLAT 8614068 353595 Serial blood samples were obtained via femoral venous catheters for tissue plasminogen activator (tPA) , [plasminogen] activator *inhibitor* ( PAI-1 ) , tPA-PAI-1 complex ( ) , and euglobulin lysis time ( ELT ) from all subjects and for fibrin degradation products ( FbDP ) and fibrinogen degradation products (FgDP) from phase II subjects . Negative_regulation PLG PLAT 8836361 386260 To evaluate the ability of commercial , chromogenic kits designed to measure human fibrinolytic pathway components to measure the canine plasma fibrinolytic pathway enzymes , and plasminogen (PLG) , and their respective *inhibitors* , [plasminogen activator inhibitor 1 (PAI)] and alpha 2-antiplasmin (AP) . Negative_regulation PLG PLAT 8840002 386671 One week before and 1 week after the conditioning programs data were collected for body weight , percentage body fat , VO2 max and 12 h fasting blood levels of total , tissue-type plasminogen activator activity ( t-PAa ) , total [plasminogen] activator *inhibitor* ( PAI-1 ) , plasminogen activator inhibitor activity ( PAI-1a ) , cholesterol ( CHOL ) , triglycerides ( TG ) , and high-density lipoprotein cholesterol ( HDL-C ) . Negative_regulation PLG PLAT 8857956 388374 In experiments using anti-actin antibodies added in excess to cultured ECs , binding of [plasminogen] was inhibited by 45 % , binding was *inhibited* by 46 % and Lp(a) binding was reduced by 56 % , confirming actin as a binding site for these various ligands whilst attesting to the presence of other EC receptors for these proteins . Negative_regulation PLG PLAU 10029447 591609 MC were examined by Giemsa staining and by immunohistochemistry using antibodies against tryptase , chymase , tissue-type plasminogen activator (tPA) , urokinase ( ) , urokinase receptor ( uPAR ) , and [plasminogen] activator *inhibitors* ( PAI-1 , PAI-2 ) . Negative_regulation PLG PLAU 10094378 601105 Ninety-eight patients with histologically confirmed ovarian tumors ( 77 primary ovarian carcinomas of stages T1 to T3 according to the postoperative histopathological classification pTNM classification , 14 ovarian metastases of various origins and seven benign ovarian tumors ) were investigated with regard to the concentration of urokinase-type plasminogen activator ( ) and [plasminogen] activator *inhibitor* ( PAI-1 ) in membrane extracts of tumors . Negative_regulation PLG PLAU 10811500 693065 ( uPA ) , its receptor ( uPAR ) and [plasminogen] activator *inhibitors* ( PAI-1 and PAI-2 ) , all play important roles in tumour invasion and metastasis . Negative_regulation PLG PLAU 11063652 746782 The aim of this study was to determine the level of mRNA expression for the genes encoding urokinase ( ) , urokinase receptor ( uPAR ) , and [plasminogen] activator *inhibitor* ( PAI-2 ) in endometrial carcinomas . Negative_regulation PLG PLAU 11113116 810473 These two studies show that rPAI-1 ( 23 ) interactions with and plasminogen can *inhibit* [plasmin] by two mechanisms . Negative_regulation PLG PLAU 11286474 799866 Whereas HMEC-proliferation was stimulated by AR , the levels of secreted urokinase-type plasminogen activator ( ) and type-1 [plasminogen] activator *inhibitor* ( PAi-1 ) remained unaffected . Negative_regulation PLG PLAU 11381061 820580 Naïve mice intracorneally infected with P. aeruginosa showed a temporally enhanced expression of tissue-type plasminogen activator ( tPA ) , urokinase-type plasminogen activator ( ) , its receptor ( uPAR ) , and [plasminogen] activator *inhibitors* 1 and 2 ( PAI-1 and PAI-2 ) , over a several-day holding period . Negative_regulation PLG PLAU 11447759 835567 MCs reacted with monoclonal antibodies to tryptase , chymase , and c-kit/CD117 and stained positively for tissue-type plasminogen activator ( tPA ) and urokinase receptor ( uPAR/CD87 ) but did not express detectable urokinase ( ) or [plasminogen] activator *inhibitors* ( PAI-1 , PAI-2 ) . Negative_regulation PLG PLAU 12011780 941504 The patients and 30 healthy controls were subjected to the following tests of the synovial fluid and plasma : the levels of tissue plasminogen activator , type 1 plasminogen activator inhibitor , plasmin-alpha 2-antiplasmin complexes , fibrinogen and von Willebrand factor antigen , the activity of , prekallikrein , alpha-2-antiplasmin , C1 inhibitor , type 1 [plasminogen] activator *inhibitor* , euglobulin clot lysis time . Negative_regulation PLG PLAU 12168869 973714 The plasminogen activator system , including urokinase-type plasminogen activator ( ) and type-1 [plasminogen] activator *inhibitor* ( PAI-1 ) , plays an important role in repair of the peritoneum damaged by several types of peritonitis . Negative_regulation PLG PLAU 12241114 989682 mRNA expression of tissue plasminogen activator (tPA) , urokinase-type plasminogen activator ( ) and [plasminogen] activator *inhibitors* ( PAI-1 , PAI-2 ) was measured by Northern blot analysis . Negative_regulation PLG PLAU 12466358 1022349 The regulated expression of the urokinase-type plasminogen activator ( ) and [plasminogen] activator *inhibitor* ( PAI-1 ) is believed to modulate the invasive capacity of human trophoblastic cells in vitro and in vivo . Negative_regulation PLG PLAU 12967140 1138864 Urokinase-type plasminogen activator ( ) , [plasminogen] activator *inhibitor* ( PAI-1 ) , and uPA receptor (uPAR) are prognostic factors in various cancer types , especially breast cancer . Negative_regulation PLG PLAU 14644129 1171982 Expression levels of mRNA , protein , and activities of were significantly higher ( p < 0.005 ) and *resulted* in more [plasminogen] activation in UCT-2 than in UCT-1 . Negative_regulation PLG PLAU 15061043 1230535 Immunohistochemical staining with tissue derived plasminogen activator ( tPA ) , urokinase derived plasminogen activator ( ) , [plasminogen] activator *inhibitor* ( PAI-1 ) and von Willebrand Factor (vWF) was performed and analyzed with bright field microscopy . Negative_regulation PLG PLAU 15138855 1246930 This article examines the prognostic importance of urinase type plasminogen activators ( ) and of [plasminogen] activator *inhibitors* ( PAI-1 ) in cases of primary oral squamous cell carcinoma . Negative_regulation PLG PLAU 15138856 1246934 This article examines the distribution and prognostic importance of urinase type plasminogen activators ( ) and of [plasminogen] activator *inhibitors* ( PAI-1 ) in cases of primary oral squamous cell carcinoma . Negative_regulation PLG PLAU 15166500 1184473 To clarify the role of proteins involved in the regulation of fibrinolysis during corneal angiogenesis , we have studied corneal vessel formation in mice deficient for ( uPA ) , tissue-type plasminogen activator ( tPA ) , [plasminogen] , plasminogen activator inhibitor-1 ( PAI-1 ) and thrombin-activatable fibrinolysis *inhibitor* ( TAFI ) . Negative_regulation PLG PLAU 15183949 1256024 To examine whether urokinase-type plasminogen activator ( ) and type 1 [plasminogen] *inhibitor* ( PAI-1 ) , DNA ploidy , and S-phase fraction (SPF) add supplementary prognostic information relative to stage and Fuhrman 's grade in renal cell carcinoma . Negative_regulation PLG PLAU 16309542 1486638 To verify the applicability of the cell invasion model , multilayer cell constructs of oral squamous cell carcinoma and oral mucosal fibroblasts were exposed to extrinsic urokinase-type plasminogen activator ( ) or [plasminogen] activator *inhibitor* ( PAI-1 ) , which are known effectors of cell migration . Negative_regulation PLG PLAU 16676075 1558930 Although the *roles* of and PAI-1 in [plasmin] generation and the degradation of fibrin are well known , recent evidence also suggests that they can participate in acute inflammatory conditions that involve neutrophil activation . Negative_regulation PLG PLAU 17141398 1815406 We determined concentrations of tissue-type plasminogen activator ( tPA ) , urokinase-type plasminogen activator ( ) , [plasminogen] activator *inhibitors* ( PAI-1 , PAI-2 ) , tPA approximately PAI-1 and uPA approximately PAI-1 complexes , and beta-hCG with enzyme linked immunosorbent assays . Negative_regulation PLG PLAU 17606760 1792589 The generation of [plasmin] involved expression of urokinase-type plasminogen activator ( uPA ) and its receptor ( uPAR ) at the surface of EMPs and was further *increased* by their ability to bind exogenous on uPAR . Negative_regulation PLG PLAU 1828371 158639 Fibrin , a positive effector of plasminogen activation by Tc-uPA or Sc-uPA preparations in the absence of DFP and dansyl-EGRck , did not promote cleavage of [plasminogen] or S-2444 by Sc-uPA in the *presence* of the inhibitors . Negative_regulation PLG PLAU 1829461 161323 In contrast to intact cells , purified receptor ( isolated from phorbol 12-myristate 13-acetate stimulated U937 cells ) was observed to partially *inhibit* uPA catalyzed [Plg] activation , although activity against low molecular weight substrates was retained . Negative_regulation PLG PLAU 1917142 168253 Chymotrypsin , [plasmin] and kallikrein were inhibited to a lesser extent , but , elastase , thrombin and papain were not *inhibited* . Negative_regulation PLG PLAU 1931618 169962 The concentrations of cathepsin D (Cath D) , urokinase ( ) and two [plasminogen] activator *inhibitors* ( PAI-1 and PAI-2 ) were analysed in the cytosols of 130 human mammary tumours ( 43 benign tumours and 87 primary and unilateral breast carcinomas ) . Negative_regulation PLG PLAU 19729604 2152347 Enhanced [plasminogen] activation , *mediated* by overexpression of ( uPA ) , accelerates atherosclerosis in apolipoprotein E-null mice . Negative_regulation PLG PLAU 21080821 2349688 The prognostic and/or predictive value of the cancer biomarkers , urokinase-type plasminogen activator ( ) and its inhibitor ( [plasminogen] activator *inhibitor* [ PAI]-1 ) , determined by ELISA in tumor-tissue extracts , was demonstrated for several cancer types in numerous clinically relevant retrospective or prospective studies , including a multicenter breast cancer therapy trial ( Chemo-N0 ) . Negative_regulation PLG PLAU 2175557 145823 Human alveolar macrophages are known to synthesize urokinase ( ) and a specific [plasminogen] activator *inhibitor* , PAI-2 . Negative_regulation PLG PLAU 21989445 2493481 Prognostic significance of urokinase-type plasminogen activator ( ) and [plasminogen] activator *inhibitor* ( PAI-1 ) in patients with primary invasive ductal breast carcinoma - a 7.5-year follow-up study . Negative_regulation PLG PLAU 21989445 2493485 Urokinase-type plasminogen activator ( ) and [plasminogen] activator *inhibitor* ( PAI-1 ) are key molecules in pericellular proteolysis , a process that plays an important role in tumor invasion and metastasis . Negative_regulation PLG PLAU 7473788 322820 An increase in the expression of and its inhibitors , [plasminogen] activator *inhibitors* I and II , was also observed between 3 and 24 h . Negative_regulation PLG PLAU 7929271 274349 The alpha 2-macroglobulin receptor/low density lipoprotein receptor related protein ( alpha 2MR/LRP ) binds several ligands , including complex between the two chain urokinase-type plasminogen activator ( ) and type-1 [plasminogen] activator *inhibitor* ( PAI-1 ) , and the single chain zymogen pro-urokinase ( pro-uPA ) . Negative_regulation PLG PLAU 8062262 268569 We have studied the prognostic value of urokinase-type plasminogen activator ( ) , uPA receptor (uPAR) , and type 1 [plasminogen] activator *inhibitor* ( PAI-1 ) in tumor extracts from 84 patients with squamous cell lung carcinoma and 38 patients with large cell lung carcinoma , measuring each molecule with sandwich enzyme linked immunosorbent assays . Negative_regulation PLG PLAU 8261432 246655 We have studied the prognostic value of urokinase-type plasminogen activator ( ) and type-1 [plasminogen] activator *inhibitor* ( PAI-1 ) in tumor extracts from 106 patients with adenocarcinoma of the lung . Negative_regulation PLG PLAU 8388317 218250 The prognostic value of urokinase-type plasminogen activator ( ) and type 1 [plasminogen] activator *inhibitor* ( PAI-1 ) levels in cytosolic extracts of ductal breast carcinomas was studied , retrospectively , in 118 premenopausal and 72 postmenopausal high-risk patients entered into the protocol of Danish Breast Cancer Cooperative Group trials for adjuvant treatment of breast cancer . Negative_regulation PLG PLAU 8830927 385644 This review focuses on the main components of the fibrinolytic system -- tissue plasminogen activator (tPA) , urokinase ( ) and [plasminogen] activator *inhibitor* ( PAI-1 ) -- and on thrombin . Negative_regulation PLG PLAU 8925884 359051 To clarify the specific expression and regulation of mRNAs for urokinase ( ) , its receptor ( uPAR ) , and type-1 [plasminogen] activator *inhibitor* ( PAI-1 ) , I analyzed RNA from four human cancer cell lines by RNA blotting after treatment with cycloheximide , anisomycin , emetine or puromycin . Negative_regulation PLG PLAU 9248850 407982 In 15 patients we investigated coagulation parameters before , during and post CPB , i.e. , fibrinogen , antithrombin (AT) III , thrombin-antithrombin complex (TAT) , prothrombin fragments F1 + 2 ( F1 + 2 ) , factor (F) XIIa , tissue factor ( TF ) , and parameters of the fibrinolytic system , i.e. , plasmin-antiplasmin-complex (PAP) , D-dimer , tissue-plasminogen-activator (tPA) , urokinase-type plasminogen activator ( ) , and [plasminogen-activator] *inhibitor* type 1 ( PAI 1 ) . Negative_regulation PLG PLAU 9272300 450576 To evaluate the effect of therapeutic and pharmacologic concentrations of two non-steroidal anti-inflammatory drugs ( NSAIDs ) , nimesulide and naproxen , on the synthesis of urokinase ( ) , [plasminogen] activator *inhibitor* ( PAI-1 ) and interleukin-6 (IL-6) in human synovial fibroblasts isolated from osteoarthritis ( OA ) patients . Negative_regulation PLG PLAU 9425170 481578 Receptor independent *role* of in pericellular [plasmin] and matrix metalloproteinase proteolysis during vascular wound healing in mice . Negative_regulation PLG PLAU 9580312 499261 Plasma tissue-type plasminogen activator (tPA) , urokinase-type plasminogen activator ( ) , and the [plasminogen] activator *inhibitors* ( PAI-1 and PAI-2 ) were evaluated and compared with plasma 17 beta-estradiol levels , ranging from 20 pg/mL to > 5,000 pg/mL during the course of treatment . Negative_regulation PLG PLAU 9815812 479656 Functional assembly of the plasminogen dependent proteolytic system on the cell surface requires multiple interactions involving urokinase ( ) , urokinase receptor ( uPAR ) , [plasminogen] activator *inhibitors* , and other molecules that mediate cell migration and adhesion . Negative_regulation PLG SERPINA5 10739384 679690 Bovine has a unique reactive site and can transiently *inhibit* [plasmin] . Negative_regulation PLG SERPINB12 11604408 888359 This hypothesis was confirmed because recombinant *inhibited* human trypsin and [plasmin] but not thrombin , coagulation factor Xa , or urokinase-type plasminogen activator . Negative_regulation PLG TFPI2 10954721 744484 Despite the fact that recombinant readily *inhibits* [plasmin] , we show that it potentiates HGF induced invasion of HCC cells and is capable of inducing invasion on its own . Negative_regulation PLG TFPI2 11027624 739240 The refolded E. coli *inhibited* [plasmin] with an inhibition constant ( K ( i ) ) of 5 nM that is similar with the TFPI-2 expressed in a mammalian system . Negative_regulation PLG TFPI2 15467913 1305813 Binding of TFPI-2 to gC1qR produced statistically significant but modest reductions in *inhibition* of [plasmin] , but had no effect on kallikrein inhibition in fluid phase chromogenic assays . Negative_regulation PLG TFPI2 8555184 347349 In addition to its ability to inhibit the amidolytic and proteolytic activities of the factor VIIa-tissue factor complex , strongly *inhibited* the amidolytic activities of human factor XIa , human plasma kallikrein , and human [plasmin] with Ki values of 15 , 25 , and 3 nM , respectively . Negative_regulation PLG TNF 1311745 179047 To determine the relative abilities of IFN and to either promote or *inhibit* [plasmin] generation , we directly compared the effects IFN and TNF , using optimal stimulating concentrations . Negative_regulation PLG TNF 17395890 1766213 Hirudin , a thrombin inhibitor , and aprotinin , an inhibitor of plasmin , reduced smoke mediated and MMP-12 release , and A1AT *inhibited* both [plasmin] and thrombin activity in a cell-free functional assay . Negative_regulation PLG TNF 21112094 2372187 *increased* EVT apoptosis , decreased villous cytotrophoblast proliferation and increased expression of pro-MMP-9 ( but not active MMP-9 ) , urokinase plasminogen activator (uPA) and [plasminogen activator inhibitor (PAI)-1] by EVT . Negative_regulation PLG TNF 3140909 99636 *increases* the production of [plasminogen] activator inhibitor in human endothelial cells in vitro and in rats in vivo . Negative_regulation PLG TNF 8898893 393153 Molecular mechanisms governing *mediated* regulation of [plasminogen-activator] inhibitor type-2 gene expression . Negative_regulation PLIN1 TNF 12898507 1118493 Pretreatment of adipocytes with PD98059 or ros significantly blocked the *induced* reduction of [perilipin] A protein level as determined by Western analysis . Negative_regulation PLIN1 TNF 17272828 1733237 Western blot analysis demonstrated that although per se *reduced* mainly [PLIN] protein expression , TNF-alpha in the presence of WP resulted in a pronounced combined reduction of both hormone-sensitive lipase (HSL) and PLIN protein . Negative_regulation PLIN1 TNF 18467379 1927370 Taken together , these results suggest that DCD mediated body fat reduction might occur as a result of *induced* downregulation of [perilipin] in adipose tissue . Negative_regulation PLIN1 TNF 19548254 2149557 also *down-regulated* the expression of [perilipin] protein . Negative_regulation PLIN1 TNF 21557215 2521412 In the in vitro lipolysis models , YC-1 attenuates TNF-a induced lipolysis of adipocytes by antagonizing *mediated* activation of ERK and downregulation of [perilipin (PLIN)] . Negative_regulation PLIN2 TNF 18037904 1889357 Finally , we demonstrate that TSA relieves *induced* repression of PPARdelta mediated transactivation of the PPARdelta target gene [adipose differentiation related protein] ( ADRP ) indicating that cross-talk between PPARdelta and NF-kappaB is of biological significance in human keratinocytes . Negative_regulation PLK1 TNF 22025632 2508090 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation PLK4 CFI 25043604 2953357 Functional characterization of , a [Polo-like kinase 4] *inhibitor* , as a potential anticancer agent . Negative_regulation PLK4 CFI 25043604 2953358 A drug discovery program culminated in , a potent and selective [PLK4] *inhibitor* . Negative_regulation PLK4 CFI 25117704 2954422 In this issue of Cancer Cell , Mason and colleagues describe the development of a [Polo-like kinase 4 (PLK4)] *inhibitor* ( ) , with promising activity against tumors formed in mice from patient derived tumor tissue . Negative_regulation PLN IL1B 9314830 455700 *inhibits* [phospholamban] gene expression in cultured cardiomyocytes . Negative_regulation PLN IL1B 9314830 455701 Western blot analyses showed that also *reduced* [phospholamban] protein levels ( 60 % of control , P < .0001 ) . Negative_regulation PLN TNF 10072733 594669 Moreover , *attenuated* the phosphorylation levels of [PLB] and TnI increased by a concentration of 0.01 microM isoproterenol , but not by 1 microM of isoproterenol . Negative_regulation PLP1 IL1B 16109311 1445239 Interestingly , both and TNF-alpha markedly *inhibited* the expression of MOG , CNPase , and [PLP] but not MBP , the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate ( PDTC ) . Negative_regulation PLP1 TNF 16109311 1445238 Interestingly , both IL-1beta and markedly *inhibited* the expression of MOG , CNPase , and [PLP] but not MBP , the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate ( PDTC ) . Negative_regulation PLVAP FZD4 21743011 2466777 Inhibition of in developing retinal vascular networks *caused* the upregulation of [PLVAP] , a protein normally associated with fenestrated , immature endothelium in the CNS . Negative_regulation PML MAP2K6 18445086 1921143 inhibition *induces* caspases activation , differentiation blockade and [PML/RARalpha] degradation in acute promyelocytic leukaemia . Negative_regulation PNLIP JAG1 23653565 2779878 Furthermore , we reveal links between the polarity field and auxin function : auxin-responsive markers such as DR5 have a broader distribution along the distal petal margin , consistent with the broad distal organiser of polarity , and [PETAL LOSS (PTL)] , which has been implicated in the control of auxin dynamics during petal initiation , is directly *repressed* by . Negative_regulation PODXL IL17A 24247026 2876428 Recombinant murine ( rmIL-17 ) had no effect on the expressions of Nephrin , Synaptopodin , and WT1 of mouse podocytes , but *caused* an decrease in the expression of [podocalyxin] as well as promoted apoptosis in a dose- and time dependent fashion . Negative_regulation PODXL TAC1 22106415 2557470 Following transplantation of green fluorescent protein ( GFP ) -positive BM , *increased* the number of BM-derived [podocalyxin] ( pos ) GFP ( pos ) endothelial cells in both strains . Negative_regulation PODXL TAC3 22106415 2557471 Following transplantation of green fluorescent protein ( GFP ) -positive BM , *increased* the number of BM-derived [podocalyxin] ( pos ) GFP ( pos ) endothelial cells in both strains . Negative_regulation PODXL TAC4 22106415 2557472 Following transplantation of green fluorescent protein ( GFP ) -positive BM , *increased* the number of BM-derived [podocalyxin] ( pos ) GFP ( pos ) endothelial cells in both strains . Negative_regulation PODXL TP53 15155752 1273259 The Wilms tumor suppressor-1 target gene [podocalyxin] is transcriptionally *repressed* by . Negative_regulation PODXL WT1 19605546 2123850 Prolonged culture of conditionally immortalized human podocytes in 25 mM glucose *induced* suppression of [podocalyxin] expression both at the protein and mRNA levels , whereas protein levels remained unaltered . Negative_regulation POLDIP2 EPHB2 17615677 1769037 We conclude that activation and [p38] MAPK *inhibition* can work in an additive manner to decrease melanogenesis . Negative_regulation POLDIP2 EPHB2 18443411 1926736 These results suggest that cyclic stretch inhibits the myogenic differentiation of C2C12 cells by activating [p38] mediated signaling and *inhibiting* phosphorylation . Negative_regulation POLDIP2 EPHB2 18567920 1952833 CypA induced nuclear factor kappaB (NF-kappaB) activity for MMP-9 transcription were strongly blocked by extracellular signal regulated kinase ( ) , c-Jun amino terminal kinase (JNK) inhibitors ( U0126 and SP600125 , respectively ) , but not by [p38] mitogen activated protein kinase (MAPK) *inhibitors* ( SB203580 ) . Negative_regulation POLDIP2 EPHB2 22129085 2624035 Treatment with 1 , 10 and 100 µg/ml AAE concentration-dependently inhibited the release of cytokines ( tumor necrosis factor-a , interleukin (IL) -6 , and IL-8 ) and phosphorylation of and JNK induced by PMACI in HMC-1 cells , but it did not *inhibit* the phosphorylation of [p38] . Negative_regulation POLDIP2 EPHB2 9822700 548868 Moreover , whereas inhibition of *had* no effect on [p38] activity , p38 inhibition consistently increased MHV-3 induced ERK activity . Negative_regulation POLDIP2 MAP2K6 11091139 754788 The fMLP mediated 5-LO product formation was also sensitive to inhibition by U0126 and to [p38] *inhibition* by SB203580 . Negative_regulation POLDIP2 MAP2K6 12649265 1080021 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant or p38beta2 MAPK *inhibited* interleukin-1beta induced [p38] MAPK activation , COX-2 gene expression , and PGE2 release . Negative_regulation POLDIP2 TNF 16813528 1580729 In addition , activation of p38 was blocked in rats treated with TNF-alpha antagonist , suggesting a *role* of in [p38] activation . Negative_regulation POLDIP2 TNF 17189827 1680095 Stimulation of cells with *resulted* in the activation of mitogen activated protein kinases (MAPK) such as c-Jun N-terminal kinase (JNK) and [p38] , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Negative_regulation POLDIP2 TNF 19192109 2049514 Microparticle generation from cultures of human aortic endothelial cells ( hAECs ) treated with and [p38] *inhibition* was quantified via multiple modalities . Negative_regulation POLDIP2 TNF 21957737 2488243 and IFN-gamma markedly *attenuated* [p38] expression in the presence of IGF-I on the 5th day of myogenesis . Negative_regulation POLDIP2 TNF 23518420 2777195 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and protein expression in the kidney , as well as *inhibiting* [p38MAPK] signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation POLDIP2 WNT7A 11822875 909129 The combination of Wnt-7a misexpression and Erk inhibition partially recovers Wnt-7a inhibition of chondrogenic differentiation , whereas the combination of misexpression and [p38] *inhibition* acts in a synergistic chondro-inhibitory fashion . Negative_regulation POMC FOXO1 19049975 2029657 *inhibits* leptin regulation of [pro-opiomelanocortin] promoter activity by blocking STAT3 interaction with specificity protein 1 . Negative_regulation POMC TFPI2 15680486 1370409 However , may *cause* mis sorting of [POMC] and POMC derived peptides at the constitutive-like secretory pathway level in an unregulated manner . Negative_regulation PON1 PLAU 22155455 2542703 decreased PON1 gene expression and activity in a dose dependent manner and accordingly *suppressed* [PON1] secretion from hepatocytes . Negative_regulation PON1 TNF 9712337 527246 Additionally , and IL-1 treatment of HepG2 cells *results* in a decrease in [PON] mRNA levels indicating that these cytokines are capable of directly affecting liver cells . Negative_regulation POT1 F2R 15078882 1251906 Concomitant stimulation of both and PAR-4 in the presence of ADP scavengers still *resulted* in a strongly reduced activation of [Rap1B] . Negative_regulation POU2F1 TNF 19074973 2035851 and IL-6 concomitantly *reduced* NTCP and OATP1B1 protein expression and NTCP , OATP , and [OCT1] transport activities . Negative_regulation POU5F1 EPHB2 22784186 2719494 In conclusion , we demonstrated that and GSK3ß signaling *increases* the number of [OCT3/4-] and NANOG positive cells in the human ICM , but does not improve stem cell derivation . Negative_regulation POU5F1 HBEGF 19919524 2166796 *reduced* SSEA-1 and elevated [OCT-3/4] , while reducing the amount of activated caspase-3 and DNA fragmentation . Negative_regulation POU5F1 MAP2K6 22784186 2719522 In conclusion , we demonstrated that and GSK3ß signaling *increases* the number of [OCT3/4-] and NANOG positive cells in the human ICM , but does not improve stem cell derivation . Negative_regulation PPARA ARSA 12368230 1019325 In hepatocytes , significantly *inhibited* [PPARalpha] protein expression and CINC-1 secretion , effects that were also observed in hepatocytes exposed to the selective PPARalpha agonist Wy-14643 . Negative_regulation PPARA CTGF 22550475 2590533 Pioglitazone treatment significantly increased [PPAR-?] expression and *inhibited* expression but had no effect on TGF-ß expression . Negative_regulation PPARA FAS 23365010 2738898 This indicates that the binding of CLAs and their precursor to PPAR subtypes *results* in [PPAR] activation , thereby induction of the target transporter genes coupled with downstream lipid metabolising genes such as ACOX-1 and PBE . Negative_regulation PPARA IL1B 12595494 1061604 ( 5 ng/ml ) *reduced* [PPARalpha] , PPARgamma , and LXRalpha mRNA expression . Negative_regulation PPARA IL1B 20054868 2201008 Consistent with these data , *suppressed* human and mouse [PPARalpha] promoter activity . Negative_regulation PPARA IL1B 9354589 461647 It was found that and IL-6 both *repress* the induction of [PPAR alpha] expression exerted by the combined action of clofibric acid and dexamethasone . Negative_regulation PPARA TNF 16847310 1625344 Moreover , significantly *reduces* [PPAR] and LXR response element-driven transcription . Negative_regulation PPARA TP63 19458633 2128290 Silencing of p63 by RNA interference and transient transfections showed that *represses* [PPARalpha] through a functional region of promoter B. Chromatin immunoprecipitation analyses indicate that p63 is bound to this region , in the absence of a recognizable p63 binding motif , suggesting that it acts through interactions with other transcription factors ( TFs ) . Negative_regulation PPARD ARSA 16141240 1507376 para NO-ASA *inhibited* intestinal tumor incidence ( 59 % ) and [PPARdelta] expression ( 55.3 % ) more than meta ( 38 and 41.5 % , respectively ) . Negative_regulation PPARD ARSA 18678619 1973302 SUL , IND , and ( 5 mM ) *suppressed* [PPARdelta] and 14-3-3 proteins in a manner parallel to PARP cleavage . Negative_regulation PPARD PTGIS 17303142 1821770 gene transfer inhibits neointimal formation by *suppressing* [PPAR delta] expression . Negative_regulation PPARG CAPN8 16857754 1613373 Under both conditions , inhibitors almost completely prevented C/EBPalpha cleavage but partially *blocked* the decrease of [PPARgamma] . Negative_regulation PPARG CCND1 12917338 1130558 [PPAR gamma] transactivation induced by the ligand BRL49653 was *inhibited* by through a pRB- and cdk independent mechanism , requiring a region predicted to form an helix-loop-helix ( HLH ) structure . Negative_regulation PPARG EPHB2 15149321 1248367 The *role* of and phosphorylation in [PPAR gamma] activation were studied , as were the effects of PPAR agonists on ERK activation and cell proliferation . Negative_regulation PPARG EPHB2 15252128 1271531 Inhibition of adipocyte differentiation by mechanical stretching through *mediated* downregulation of [PPARgamma2] . Negative_regulation PPARG EPHB2 19191008 2049488 PI-3 K/AKT and signaling pathways *mediate* leptin induced inhibition of [PPARgamma] gene expression in primary rat hepatic stellate cells . Negative_regulation PPARG FOXO1 12966085 1158329 One mechanism by which Foxo1 antagonizes PPARgamma activity is through disruption of DNA binding as *inhibited* the DNA binding activity of a [PPARgamma/retinoid] X receptor alpha heterodimeric complex . Negative_regulation PPARG FOXO1 16670091 1583509 Phosphorylation-defective mutants T24A , S256A , S319A , and T24A/S256A/S319A still *repressed* the [PPARgamma1] promoter and partially lost their effects on the PPARgamma2 promoter in either basal or insulin stimulated cells . Negative_regulation PPARG IL1B 12595494 1061605 ( 5 ng/ml ) *reduced* PPARalpha , [PPARgamma] , and LXRalpha mRNA expression . Negative_regulation PPARG TNF 10405788 629363 5. Thiazolidinediones dose-dependently recovered *induced* down-regulation of [PPAR gamma] mRNA expression . Negative_regulation PPARG TNF 15284209 1302581 significantly *suppressed* [PPARgamma2] gene transcription ( to approximately 50 % ) , and deletion analyses demonstrated that the suppression was mediated via CCAAT/enhancer binding protein (C/EBP) binding elements at the -320/-340 region of the promoter . Negative_regulation PPARG TNF 15284209 1302582 Overexpression of CEBP/delta prevented the *mediated* suppression of [PPARgamma2] transactivation . Negative_regulation PPARG TNF 15284209 1302584 Taken together , *suppresses* [PPARgamma2] gene transcription by the inhibition of C/EBPdelta expression and its DNA binding during the early stage of adipocyte differentiation , which may contribute to the inhibition of adipocyte differentiation , as well as the induction of insulin resistance . Negative_regulation PPARG TNF 16958658 1611137 The authors also demonstrated that and Wnt , known mediators of anti-adipogenesis , also *suppress* the activity of [PPAR-gamma] and contribute to HSC-MF transdifferentiation . Negative_regulation PPARG TNF 17989144 1850959 significantly *attenuated* [PPAR-gamma] gene expression in KCs . Negative_regulation PPARG TNF 19225048 2061700 Curcumin dose dependently antagonized the *mediated* decrease in [PPARgamma] and blocked transactivation of NF-kappaB and repression of PPARgamma , indicating that the anti-inflamatory property of curcumin may be responsible for alleviating CRF in Nx animals . Negative_regulation PPARGC1A FOXO1 16203862 1483219 [PGC-1alpha] gene expression is *down-regulated* by Akt- mediated phosphorylation and nuclear exclusion of in insulin stimulated skeletal muscle . Negative_regulation PPARGC1A TNF 19038972 2035250 *reduces* [PGC-1alpha] expression through NF-kappaB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model . Negative_regulation PPARGC1A TNF 19038972 2035251 The mechanism by which *reduced* [PGC-1alpha] expression in vitro appeared to be largely mediated via both p38 mitogen activated protein kinase and nuclear factor-kappaB pathways . Negative_regulation PPARGC1A TNF 19859910 2184270 *mediated* reduction in [PGC-1alpha] may impair skeletal muscle function after cigarette smoke exposure . Negative_regulation PPARGC1A TNF 19859910 2184271 These data suggest that in response to smoke exposure , *mediated* down-regulation of [PGC-1alpha] may be a key step leading to vascular and myocyte dysfunction , effects that are more evident in oxidative than glycolytic skeletal muscles . Negative_regulation PPARGC1A TNF 20211864 2287458 We addressed the specific mechanisms by which exposure to *results* in [PGC-1alpha] down-regulation in cardiac cells and , as a consequence , in the metabolic dysregulation that underlies heart dysfunction and failure . Negative_regulation PPAT TCN1 2480792 121739 Thus , *inhibits* [amidophosphoribosyltransferase] ; Negative_regulation PPBP CSF1 21159337 2384809 *inhibited* the expression of [pro-platelet basic protein (PPBP)] induced by GM-CSF . Negative_regulation PPBP IL6 23136963 2710744 Now we intend to determine the expression pattern of CXCL7 and the *role* of in [CXCL7] induction during spontaneous progressive ( P ) and regressive ( R ) phases in canine transmissible venereal tumor ( CTVT ) . Negative_regulation PPID TFPI2 22045333 2534015 Addition of or cyclophilin binding drug cyclosporine A *prevented* the association of endogenous [CYP40] with HSP90-AGO1 complex and inhibited RISC assembly . Negative_regulation PPIF EPHB2 20080742 2194332 inhibition *enhanced* glycogen synthase kinase-3 (GSK-3) dependent phosphorylation of the pore regulator [cyclophilin D] , whereas GSK-3 inhibition protected from PTP opening . Negative_regulation PPP1CC TNF 22025632 2508091 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation PPP1R14A EPHB2 23511142 2757005 AngII increased the activity of protein kinase C-dependent phosphatase inhibitor of 17-kD ( CPI17 ) , integrin linked kinase (ILK) , and zipper interacting protein kinase (ZIPK) , The effect of AngII on [CPI17] was *blocked* by and p38 MAPK inhibitor , while the effect of AngII on ILK and ZIPK was only blocked by ERK inhibitor . Negative_regulation PPP1R14A IL1B 17307724 1733706 Among the various proinflammatory cytokines tested , TNF-alpha and were observed to directly *inhibit* [CPI-17] expression and contraction in cultured rat intestinal tissue . Negative_regulation PPP1R14A IL1B 17307724 1733708 Moreover , both TNF-alpha and *inhibited* [CPI-17] expression and contraction of smooth muscle tissue isolated from wild-type and IL-1alpha/beta double-knockout mice . Negative_regulation PPP1R14A TNF 17307724 1733705 Among the various proinflammatory cytokines tested , and IL-1beta were observed to directly *inhibit* [CPI-17] expression and contraction in cultured rat intestinal tissue . Negative_regulation PPP1R14A TNF 17307724 1733707 Moreover , both and IL-1beta *inhibited* [CPI-17] expression and contraction of smooth muscle tissue isolated from wild-type and IL-1alpha/beta double-knockout mice . Negative_regulation PPP1R17 CAPN8 19105197 2042112 These data strongly suggest that *mediated* loss of [G-substrate] represents an important mechanism contributing to NMDA induced amacrine cell death . Negative_regulation PPP1R9B PTGER2 17408863 1736034 Use of antisense oligonucleotides against the mRNA for each receptor reveals that either or EP3 receptor knockdown *reduces* [spinophilin] in PGE2- or estradiol treated females , whereas reducing EP1 or EP4 receptor levels by the same means has a smaller but also significant effect . Negative_regulation PPP2CA FOXO1 18077353 1836768 In addition , activity suppresses protein phosphatase 2A (PP2A) and *disrupts* [Akt-PP2A] and Akt-calcineurin interactions . Negative_regulation PPP2CA NMNAT2 23579329 2794784 Moreover , we further demonstrated that overexpression of could *activate* [PP2A] with attenuation of tau phosphorylation , whereas downregulation of Nmnat2 by shRNA inhibited PP2A with tau hyperphosphorylation at multiple AD-associated sites . Negative_regulation PPP2CA TNF 17314097 1719513 Interestingly , peptides spanning CCR2 and/or LZ disrupt IKKgamma-Tax and [IKKgamma-PP2A] interactions and potently *inhibit* NF-kappaB activation by Tax and . Negative_regulation PPP2CA TNF 20363734 2266638 We found that either [PP2A] inhibitor okadaic acid or depletion of catalytic subunit alpha of PP2A ( PP2A/Calpha ) by small interfering RNA enhanced Bcl-x ( L ) phosphorylation when activated with hydrogen peroxide and alpha *induced* oxidative stress . Negative_regulation PPP2CA TNF 22718360 2715405 Moreover , ATRA and LGD1069 reversed the decreased [PP2A] activity and *inhibited* the activation of IKK/I?Ba and gene expression of MCP-1 , IL-6 , and in the hearts of Zucker diabetic fatty rats . Negative_regulation PPP2R1A FOXO1 18077353 1836772 In addition , activity suppresses protein phosphatase 2A (PP2A) and *disrupts* [Akt-PP2A] and Akt-calcineurin interactions . Negative_regulation PPP2R1A NMNAT2 23579329 2794785 Moreover , we further demonstrated that overexpression of could *activate* [PP2A] with attenuation of tau phosphorylation , whereas downregulation of Nmnat2 by shRNA inhibited PP2A with tau hyperphosphorylation at multiple AD-associated sites . Negative_regulation PPP2R1A TNF 17314097 1719517 Interestingly , peptides spanning CCR2 and/or LZ disrupt IKKgamma-Tax and [IKKgamma-PP2A] interactions and potently *inhibit* NF-kappaB activation by Tax and . Negative_regulation PPP2R1A TNF 20363734 2266639 We found that either [PP2A] inhibitor okadaic acid or depletion of catalytic subunit alpha of PP2A ( PP2A/Calpha ) by small interfering RNA enhanced Bcl-x ( L ) phosphorylation when activated with hydrogen peroxide and alpha *induced* oxidative stress . Negative_regulation PPP2R1A TNF 22718360 2715411 Moreover , ATRA and LGD1069 reversed the decreased [PP2A] activity and *inhibited* the activation of IKK/I?Ba and gene expression of MCP-1 , IL-6 , and in the hearts of Zucker diabetic fatty rats . Negative_regulation PPP2R2B FOXO1 18077353 1836776 In addition , activity suppresses protein phosphatase 2A (PP2A) and *disrupts* [Akt-PP2A] and Akt-calcineurin interactions . Negative_regulation PPP2R2B NMNAT2 23579329 2794786 Moreover , we further demonstrated that overexpression of could *activate* [PP2A] with attenuation of tau phosphorylation , whereas downregulation of Nmnat2 by shRNA inhibited PP2A with tau hyperphosphorylation at multiple AD-associated sites . Negative_regulation PPP2R2B TNF 17314097 1719521 Interestingly , peptides spanning CCR2 and/or LZ disrupt IKKgamma-Tax and [IKKgamma-PP2A] interactions and potently *inhibit* NF-kappaB activation by Tax and . Negative_regulation PPP2R2B TNF 20363734 2266640 We found that either PP2A inhibitor okadaic acid or depletion of catalytic subunit alpha of [PP2A] ( PP2A/Calpha ) by small interfering RNA enhanced Bcl-x ( L ) phosphorylation when activated with hydrogen peroxide and alpha *induced* oxidative stress . Negative_regulation PPP2R2B TNF 22718360 2715417 Moreover , ATRA and LGD1069 reversed the decreased [PP2A] activity and *inhibited* the activation of IKK/I?Ba and gene expression of MCP-1 , IL-6 , and in the hearts of Zucker diabetic fatty rats . Negative_regulation PPP3CA EDN2 15619133 1348847 In 11 renal transplant patients , blood CsA concentrations , [calcineurin] *inhibition* in peripheral blood mononuclear cells and plasma concentrations were measured over a 4-h period after CsA intake . Negative_regulation PPP3CA FBXO32 15489953 1321341 Conversely , downregulation of using adenoviral small interfering RNA ( siRNA ) expression *enhances* agonist induced [calcineurin] activity and cardiomyocyte hypertrophy . Negative_regulation PPP3CA FOXO1 16952979 1615675 Here , we report that expression of either or Foxo3 in cardiomyocytes *attenuates* [calcineurin] phosphatase activity and inhibits agonist induced hypertrophic growth . Negative_regulation PPP3CA FOXO1 18077353 1836780 In addition , activity suppresses protein phosphatase 2A (PP2A) and *disrupts* Akt-PP2A and [Akt-calcineurin] interactions . Negative_regulation PPP3CA FOXO1 21080037 2371619 regulates muscle fiber-type specification and *inhibits* [calcineurin] signaling during C2C12 myoblast differentiation . Negative_regulation PPP3CA FOXO1 21080037 2371621 Using C2C12 myoblast , constitutively active mutant altered the proportion of muscle fiber type composition toward a fast-glycolytic phenotype and *attenuated* [calcineurin] phosphatase activity . Negative_regulation PPP3CA RCAN1 11231093 789471 , a novel endogenous *inhibitor* of [calcineurin] signaling , is expressed in the primitive ventricle of the heart and during neurogenesis . Negative_regulation PPP3CA RCAN1 11786544 916804 It is not known whether overexpression of , a recently described endogenous *inhibitor* of [calcineurin] , impacts the hypertrophic response to pathophysiologically relevant pressure overload . Negative_regulation PPP3CA RCAN1 11786544 916806 These data demonstrate attenuation of hypertrophic transformation when [calcineurin] is *inhibited* by . Negative_regulation PPP3CA RCAN1 12063245 968864 We conclude that *inhibits* [calcineurin] through mechanisms that include , but are not limited to , competition with other substrates such as nuclear factor of activated T-cells . Negative_regulation PPP3CA RCAN1 12515860 1039261 These findings suggest that can facilitate or *suppress* cardiac [calcineurin] signaling depending on the nature of the hypertrophic stimulus . Negative_regulation PPP3CA RCAN1 12809556 1120691 Taking all these results into consideration we suggest that phosphorylation of is *involved* in the regulation of the phosphatase activity of [calcineurin] and can therefore act as a modulator of calcineurin dependent cellular pathways . Negative_regulation PPP3CA RCAN1 16155351 1455497 Expression of , an *inhibitor* of the phosphatase [calcineurin] , is altered with aging and Alzheimer 's disease . Negative_regulation PPP3CA RCAN1 18294449 1878652 Ectopic expression also *inhibited* [calcineurin] signaling in the HUVEC cells . Negative_regulation PPP3CA RCAN1 19322033 2106123 We determined that overexpression of *leads* to increased proteolytic cleavage of [calcineurin] . Negative_regulation PPP3CA RCAN1 19332797 2056459 Our results therefore indicate that the inhibitory action of RCAN on [calcineurin-NFAT] signaling *results* not only from the inhibition of phosphatase activity but also from competition between NFAT and for binding to the same docking site in calcineurin . Negative_regulation PPP3CA RCAN1 19926569 2190230 We show that induction of *inhibits* [calcineurin/NFAT] signaling through a negative feedback mechanism ; Negative_regulation PPP3CA RCAN1 20371871 2261755 *inhibits* the protein phosphatase [calcineurin] and is required for appropriate immune responses , synaptic plasticity , vascular tone , angiogenesis , and cardiac remodeling . Negative_regulation PPP3CA RCAN1 21890628 2496514 Furthermore , we found that the increased activation of CREB signaling by RCAN1 depended on the ability of to *inhibit* [calcineurin] activity . Negative_regulation PPP3CA RCAN1 21965663 2507435 Phosphorylation of RCAN1 at Thr ( 192 ) by Dyrk1A enhances the ability of to *inhibit* the phosphatase activity of [calcineurin (Caln)] , leading to reduced NFAT transcriptional activity and enhanced Tau phosphorylation . Negative_regulation PPP3CA RCAN1 22864830 2641148 In addition , we found that unphosphorylated noncompetitively *inhibits* [calcineurin] protein phosphatase activity and that the phosphorylation of RCAN1 by p38a MAP kinase decreases the binding affinity of RCAN1 for calcineurin . Negative_regulation PPP3CB FBXO32 15489953 1321342 Conversely , downregulation of using adenoviral small interfering RNA ( siRNA ) expression *enhances* agonist induced [calcineurin] activity and cardiomyocyte hypertrophy . Negative_regulation PPP3CB FOXO1 21080037 2371622 Using C2C12 myoblast , constitutively active mutant altered the proportion of muscle fiber type composition toward a fast-glycolytic phenotype and *attenuated* [calcineurin] phosphatase activity . Negative_regulation PPP3CB RCAN1 11231093 789472 , a novel endogenous *inhibitor* of [calcineurin] signaling , is expressed in the primitive ventricle of the heart and during neurogenesis . Negative_regulation PPP3CB RCAN1 11786544 916807 These data demonstrate attenuation of hypertrophic transformation when [calcineurin] is *inhibited* by . Negative_regulation PPP3CB RCAN1 12515860 1039262 These findings suggest that can facilitate or *suppress* cardiac [calcineurin] signaling depending on the nature of the hypertrophic stimulus . Negative_regulation PPP3CB RCAN1 12809556 1120692 Taking all these results into consideration we suggest that phosphorylation of is *involved* in the regulation of the phosphatase activity of [calcineurin] and can therefore act as a modulator of calcineurin dependent cellular pathways . Negative_regulation PPP3CB RCAN1 16155351 1455498 Expression of , an *inhibitor* of the phosphatase [calcineurin] , is altered with aging and Alzheimer 's disease . Negative_regulation PPP3CB RCAN1 18294449 1878653 Ectopic expression also *inhibited* [calcineurin] signaling in the HUVEC cells . Negative_regulation PPP3CB RCAN1 19322033 2106124 We determined that overexpression of *leads* to increased proteolytic cleavage of [calcineurin] . Negative_regulation PPP3CB RCAN1 19332797 2056462 Our results therefore indicate that the inhibitory action of RCAN on [calcineurin-NFAT] signaling *results* not only from the inhibition of phosphatase activity but also from competition between NFAT and for binding to the same docking site in calcineurin . Negative_regulation PPP3CB RCAN1 19926569 2190231 We show that induction of *inhibits* [calcineurin/NFAT] signaling through a negative feedback mechanism ; Negative_regulation PPP3CB RCAN1 20371871 2261756 *inhibits* the protein phosphatase [calcineurin] and is required for appropriate immune responses , synaptic plasticity , vascular tone , angiogenesis , and cardiac remodeling . Negative_regulation PPP3CB RCAN1 22864830 2641149 In addition , we found that unphosphorylated noncompetitively *inhibits* [calcineurin] protein phosphatase activity and that the phosphorylation of RCAN1 by p38a MAP kinase decreases the binding affinity of RCAN1 for calcineurin . Negative_regulation PPP3CC FBXO32 15489953 1321343 Conversely , downregulation of using adenoviral small interfering RNA ( siRNA ) expression *enhances* agonist induced [calcineurin] activity and cardiomyocyte hypertrophy . Negative_regulation PPP3CC FOXO1 21080037 2371623 Using C2C12 myoblast , constitutively active mutant altered the proportion of muscle fiber type composition toward a fast-glycolytic phenotype and *attenuated* [calcineurin] phosphatase activity . Negative_regulation PPP3CC RCAN1 11231093 789473 , a novel endogenous *inhibitor* of [calcineurin] signaling , is expressed in the primitive ventricle of the heart and during neurogenesis . Negative_regulation PPP3CC RCAN1 11786544 916808 These data demonstrate attenuation of hypertrophic transformation when [calcineurin] is *inhibited* by . Negative_regulation PPP3CC RCAN1 12515860 1039263 These findings suggest that can facilitate or *suppress* cardiac [calcineurin] signaling depending on the nature of the hypertrophic stimulus . Negative_regulation PPP3CC RCAN1 12809556 1120693 Taking all these results into consideration we suggest that phosphorylation of is *involved* in the regulation of the phosphatase activity of [calcineurin] and can therefore act as a modulator of calcineurin dependent cellular pathways . Negative_regulation PPP3CC RCAN1 16155351 1455499 Expression of , an *inhibitor* of the phosphatase [calcineurin] , is altered with aging and Alzheimer 's disease . Negative_regulation PPP3CC RCAN1 18294449 1878654 Ectopic expression also *inhibited* [calcineurin] signaling in the HUVEC cells . Negative_regulation PPP3CC RCAN1 19322033 2106125 We determined that overexpression of *leads* to increased proteolytic cleavage of [calcineurin] . Negative_regulation PPP3CC RCAN1 19332797 2056465 Our results therefore indicate that the inhibitory action of RCAN on [calcineurin-NFAT] signaling *results* not only from the inhibition of phosphatase activity but also from competition between NFAT and for binding to the same docking site in calcineurin . Negative_regulation PPP3CC RCAN1 19926569 2190232 We show that induction of *inhibits* [calcineurin/NFAT] signaling through a negative feedback mechanism ; Negative_regulation PPP3CC RCAN1 20371871 2261757 *inhibits* the protein phosphatase [calcineurin] and is required for appropriate immune responses , synaptic plasticity , vascular tone , angiogenesis , and cardiac remodeling . Negative_regulation PPP3CC RCAN1 22864830 2641150 In addition , we found that unphosphorylated noncompetitively *inhibits* [calcineurin] protein phosphatase activity and that the phosphorylation of RCAN1 by p38a MAP kinase decreases the binding affinity of RCAN1 for calcineurin . Negative_regulation PPP3R1 EDN2 15619133 1348850 In 11 renal transplant patients , blood CsA concentrations , [calcineurin] *inhibition* in peripheral blood mononuclear cells and plasma concentrations were measured over a 4-h period after CsA intake . Negative_regulation PPP3R1 FOXO1 16952979 1615677 Here , we report that expression of either or Foxo3 in cardiomyocytes *attenuates* [calcineurin] phosphatase activity and inhibits agonist induced hypertrophic growth . Negative_regulation PPP3R1 FOXO1 18077353 1836784 In addition , activity suppresses protein phosphatase 2A (PP2A) and *disrupts* Akt-PP2A and [Akt-calcineurin] interactions . Negative_regulation PPP3R1 FOXO1 21080037 2371620 regulates muscle fiber-type specification and *inhibits* [calcineurin] signaling during C2C12 myoblast differentiation . Negative_regulation PPP3R1 RCAN1 11786544 916805 It is not known whether overexpression of , a recently described endogenous *inhibitor* of [calcineurin] , impacts the hypertrophic response to pathophysiologically relevant pressure overload . Negative_regulation PPP3R1 RCAN1 12063245 968865 We conclude that *inhibits* [calcineurin] through mechanisms that include , but are not limited to , competition with other substrates such as nuclear factor of activated T-cells . Negative_regulation PPP3R1 RCAN1 21890628 2496515 Furthermore , we found that the increased activation of CREB signaling by RCAN1 depended on the ability of to *inhibit* [calcineurin] activity . Negative_regulation PPP3R1 RCAN1 21965663 2507436 Phosphorylation of RCAN1 at Thr ( 192 ) by Dyrk1A enhances the ability of to *inhibit* the phosphatase activity of [calcineurin (Caln)] , leading to reduced NFAT transcriptional activity and enhanced Tau phosphorylation . Negative_regulation PPP4C IL1B 16830232 1586796 Based on these findings , we propose that *mediated* inhibition of [PP4] activity might result in the retention of lamin-B in its phosphorylated state , which is a requisite for its degradation by caspases leading to the apoptotic demise of the beta cell ( Veluthakal et al. : Am J Physiol Cell Physiol 287 : C1152-C1162 , 2004 ) . Negative_regulation PRDX1 IL1B 17890051 1843605 *Role* of and 5-HT2 receptors in midbrain [periaqueductal gray (PAG)] in potentiating defensive rage behavior in cat . Negative_regulation PRDX2 CCND1 15585645 1345669 Taken together , our data show that [TSA] effectively *induces* down-regulation through both ERalpha dependent and ERalpha independent mechanisms , providing an important new strategy for combating resistance to antiestrogens . Negative_regulation PRDX2 TNF 17005413 1641117 Coincident with this observation , [TSA] *induced* a concentration dependent reduction of constitutive and induced NF-kappaB activation in Tca8113 cells . Negative_regulation PRDX2 TNF 20130413 2293650 stimulation activated NF-kappaB through induction of IkappaB phosphorylation , but the activation can be *suppressed* by [TSA] . Negative_regulation PRG2 ARSA 1433013 204583 TA did not depress chondroformative variables in human cartilage in vitro , while *induced* a decrease of DNA and [proteoglycan] syntheses . Negative_regulation PRG2 IL1B 10025918 591178 If NO production is blocked , much of the *inhibition* of [proteoglycan] synthesis is prevented . Negative_regulation PRG2 IL1B 10438960 635213 The inhibition of iNOS induction by CTS is paralleled by abrogation of *induced* down-regulation of [proteoglycan] synthesis . Negative_regulation PRG2 IL1B 10861084 705270 Additionally , CTS augments the reparative process via hyperinduction of aggrecan mRNA expression and abrogation of *induced* suppression of [proteoglycan] synthesis . Negative_regulation PRG2 IL1B 10913361 716272 The enhanced synthesis of [proteoglycan] induced at all ages by TGF-beta1 was *down-regulated* by and retinoic acid . Negative_regulation PRG2 IL1B 11007768 752575 Human chondrocytes that overexpressed IL-1RII were resistant to IL-1 induced mRNA accumulation and *inhibition* of [proteoglycan] synthesis . Negative_regulation PRG2 IL1B 11457450 838162 15-deoxy-Delta12,14-prostaglandin J2 ( 15d-PGJ2 ) , in contrast to troglitazone , was highly potent to counteract *induced* cyclooxygenase-2 and inductible nitric oxide synthase expression , NO production and the decrease in [proteoglycan] synthesis . Negative_regulation PRG2 IL1B 12096231 960888 Both PBMC and plus TNF-alpha *induced* strong inhibition of cartilage [proteoglycan] synthesis and significant enhancement of the release of proteoglycans , diminishing proteoglycan content . Negative_regulation PRG2 IL1B 14499180 1143652 stimulated the release of matrix sulfated proteoglycans in the culture medium , and significantly *inhibited* sulfated [proteoglycan] synthesis . Negative_regulation PRG2 IL1B 9416852 472214 The present study was conducted to determine whether stimulation of human articular chondrocytes with OP-1 can help overcome *induced* suppression of [35S-proteoglycan] synthesis . Negative_regulation PRG2 IL1B 9416852 472217 at 10 pg/ml *caused* a 60 % decrease in [35S-proteoglycan] synthesis . Negative_regulation PRG2 MAP2K6 15801908 1432372 Instead , in alginate- cultured chondrocytes , the inhibitors *increased* IGF-I stimulated [proteoglycan] synthesis when compared with cells treated with IGF-I alone . Negative_regulation PRG2 MAP2K6 19762915 2158802 Lentivirus mediated overexpression of constitutively active ( CA ) Akt significantly enhanced proteoglycan synthesis , whereas both dominant negative Akt and CA *inhibited* [proteoglycan] synthesis . Negative_regulation PRG2 MMP28 10525477 654053 The Fn-fs up-regulate expression , significantly *enhance* degradation and loss of [proteoglycan (PG)] from cartilage and temporarily suppress PG synthesis , all events observed in OA . Negative_regulation PRG2 MMP28 16563811 1582372 Inhibition of activity *reduced* both [proteoglycan] loss and type II collagen degradation . Negative_regulation PRG2 MMP7 10525477 654068 The Fn-fs up-regulate expression , significantly *enhance* degradation and loss of [proteoglycan (PG)] from cartilage and temporarily suppress PG synthesis , all events observed in OA . Negative_regulation PRG2 MMP7 16563811 1582387 Inhibition of activity *reduced* both [proteoglycan] loss and type II collagen degradation . Negative_regulation PRG2 S100B 9796780 543466 Here , it was demonstrated that 5-HT stimulates expression of cartilage [proteoglycan] core protein , and *inhibits* expression of and tenascin in mandibular explants . Negative_regulation PRG2 TNF 10857772 704543 ( 10 ng/ml ) stimulated [ 3H ] thymidine incorporation in undifferentiated ATDC5 cells , and *suppressed* cartilaginous nodule formation and the accumulation of cartilage-specific [proteoglycan] . Negative_regulation PRG2 TNF 11665971 872286 Additionally , CTS augments the reparative process via abrogation of *induced* suppression of [proteoglycan] synthesis . Negative_regulation PRG2 TNF 12096231 960887 Both PBMC and IL-1beta plus *induced* strong inhibition of cartilage [proteoglycan] synthesis and significant enhancement of the release of proteoglycans , diminishing proteoglycan content . Negative_regulation PRG2 TNF 15564062 1341376 *prevented* the mechanical stimulation of [proteoglycan] synthesis , and this effect was not dependent on NOS2 . Negative_regulation PRG2 TNF 1863822 163999 In both young and old human articular cartilage explants , *induced* a concentration dependent , reversible suppression of the [proteoglycan (PG)] synthesis . Negative_regulation PRG2 TNF 22038356 2499441 The result showed that increased the expression of ß-catenin and MMP-13 , and significantly *inhibited* the synthesis of type II collagen and [proteoglycan] , which resulted in the degeneration of nucleus pulposus cells . Negative_regulation PRG2 TNF 3498042 77901 also has been shown to cause similar cartilage degradation and both cytokines *inhibit* resynthesis of [proteoglycan] . Negative_regulation PRG2 TNF 3736671 62695 I report here that recombinant human stimulates resorption and *inhibits* synthesis of [proteoglycan] in explants of cartilage . Negative_regulation PRG2 TNF 7794042 313507 However , neutralising with a monoclonal antibody was effective in suppressing inflammatory changes in the joint during the acute onset of AIA , but it *had* little effect on the loss of [proteoglycan] from cartilage . Negative_regulation PRG2 TNF 7814444 292684 *reduces* [proteoglycan] synthesis in cultured endothelial cells . Negative_regulation PRG2 TNF 9770330 538827 In contrast , neutralization of IL-1 , but not , *resulted* in a significant decrease of chondrocyte [proteoglycan] synthesis inhibition . Negative_regulation PRG3 ARSA 1433013 204584 TA did not depress chondroformative variables in human cartilage in vitro , while *induced* a decrease of DNA and [proteoglycan] syntheses . Negative_regulation PRG3 IL1B 10025918 591179 If NO production is blocked , much of the *inhibition* of [proteoglycan] synthesis is prevented . Negative_regulation PRG3 IL1B 10438960 635214 The inhibition of iNOS induction by CTS is paralleled by abrogation of *induced* down-regulation of [proteoglycan] synthesis . Negative_regulation PRG3 IL1B 10861084 705271 Additionally , CTS augments the reparative process via hyperinduction of aggrecan mRNA expression and abrogation of *induced* suppression of [proteoglycan] synthesis . Negative_regulation PRG3 IL1B 10913361 716273 The enhanced synthesis of [proteoglycan] induced at all ages by TGF-beta1 was *down-regulated* by and retinoic acid . Negative_regulation PRG3 IL1B 11007768 752577 Human chondrocytes that overexpressed IL-1RII were resistant to IL-1 induced mRNA accumulation and *inhibition* of [proteoglycan] synthesis . Negative_regulation PRG3 IL1B 11457450 838163 15-deoxy-Delta12,14-prostaglandin J2 ( 15d-PGJ2 ) , in contrast to troglitazone , was highly potent to counteract *induced* cyclooxygenase-2 and inductible nitric oxide synthase expression , NO production and the decrease in [proteoglycan] synthesis . Negative_regulation PRG3 IL1B 12096231 960890 Both PBMC and plus TNF-alpha *induced* strong inhibition of cartilage [proteoglycan] synthesis and significant enhancement of the release of proteoglycans , diminishing proteoglycan content . Negative_regulation PRG3 IL1B 14499180 1143653 stimulated the release of matrix sulfated proteoglycans in the culture medium , and significantly *inhibited* sulfated [proteoglycan] synthesis . Negative_regulation PRG3 IL1B 9416852 472215 The present study was conducted to determine whether stimulation of human articular chondrocytes with OP-1 can help overcome *induced* suppression of [35S-proteoglycan] synthesis . Negative_regulation PRG3 IL1B 9416852 472218 at 10 pg/ml *caused* a 60 % decrease in [35S-proteoglycan] synthesis . Negative_regulation PRG3 MAP2K6 15801908 1432379 Instead , in alginate- cultured chondrocytes , the inhibitors *increased* IGF-I stimulated [proteoglycan] synthesis when compared with cells treated with IGF-I alone . Negative_regulation PRG3 MAP2K6 19762915 2158812 Lentivirus mediated overexpression of constitutively active ( CA ) Akt significantly enhanced proteoglycan synthesis , whereas both dominant negative Akt and CA *inhibited* [proteoglycan] synthesis . Negative_regulation PRG3 MMP28 10525477 654075 The Fn-fs up-regulate expression , significantly *enhance* degradation and loss of [proteoglycan (PG)] from cartilage and temporarily suppress PG synthesis , all events observed in OA . Negative_regulation PRG3 MMP28 16563811 1582394 Inhibition of activity *reduced* both [proteoglycan] loss and type II collagen degradation . Negative_regulation PRG3 MMP7 10525477 654090 The Fn-fs up-regulate expression , significantly *enhance* degradation and loss of [proteoglycan (PG)] from cartilage and temporarily suppress PG synthesis , all events observed in OA . Negative_regulation PRG3 MMP7 16563811 1582409 Inhibition of activity *reduced* both [proteoglycan] loss and type II collagen degradation . Negative_regulation PRG3 S100B 9796780 543468 Here , it was demonstrated that 5-HT stimulates expression of cartilage [proteoglycan] core protein , and *inhibits* expression of and tenascin in mandibular explants . Negative_regulation PRG3 TNF 10857772 704544 ( 10 ng/ml ) stimulated [ 3H ] thymidine incorporation in undifferentiated ATDC5 cells , and *suppressed* cartilaginous nodule formation and the accumulation of cartilage-specific [proteoglycan] . Negative_regulation PRG3 TNF 11665971 872287 Additionally , CTS augments the reparative process via abrogation of *induced* suppression of [proteoglycan] synthesis . Negative_regulation PRG3 TNF 12096231 960889 Both PBMC and IL-1beta plus *induced* strong inhibition of cartilage [proteoglycan] synthesis and significant enhancement of the release of proteoglycans , diminishing proteoglycan content . Negative_regulation PRG3 TNF 15564062 1341377 *prevented* the mechanical stimulation of [proteoglycan] synthesis , and this effect was not dependent on NOS2 . Negative_regulation PRG3 TNF 1863822 164000 In both young and old human articular cartilage explants , *induced* a concentration dependent , reversible suppression of the [proteoglycan (PG)] synthesis . Negative_regulation PRG3 TNF 22038356 2499443 The result showed that increased the expression of ß-catenin and MMP-13 , and significantly *inhibited* the synthesis of type II collagen and [proteoglycan] , which resulted in the degeneration of nucleus pulposus cells . Negative_regulation PRG3 TNF 3498042 77902 also has been shown to cause similar cartilage degradation and both cytokines *inhibit* resynthesis of [proteoglycan] . Negative_regulation PRG3 TNF 3736671 62696 I report here that recombinant human stimulates resorption and *inhibits* synthesis of [proteoglycan] in explants of cartilage . Negative_regulation PRG3 TNF 7794042 313508 However , neutralising with a monoclonal antibody was effective in suppressing inflammatory changes in the joint during the acute onset of AIA , but it *had* little effect on the loss of [proteoglycan] from cartilage . Negative_regulation PRG3 TNF 7814444 292685 *reduces* [proteoglycan] synthesis in cultured endothelial cells . Negative_regulation PRG3 TNF 9770330 538828 In contrast , neutralization of IL-1 , but not , *resulted* in a significant decrease of chondrocyte [proteoglycan] synthesis inhibition . Negative_regulation PRG4 ARSA 1433013 204585 TA did not depress chondroformative variables in human cartilage in vitro , while *induced* a decrease of DNA and [proteoglycan] syntheses . Negative_regulation PRG4 IL1B 10025918 591180 If NO production is blocked , much of the *inhibition* of [proteoglycan] synthesis is prevented . Negative_regulation PRG4 IL1B 10438960 635215 The inhibition of iNOS induction by CTS is paralleled by abrogation of *induced* down-regulation of [proteoglycan] synthesis . Negative_regulation PRG4 IL1B 10861084 705272 Additionally , CTS augments the reparative process via hyperinduction of aggrecan mRNA expression and abrogation of *induced* suppression of [proteoglycan] synthesis . Negative_regulation PRG4 IL1B 10913361 716274 The enhanced synthesis of [proteoglycan] induced at all ages by TGF-beta1 was *down-regulated* by and retinoic acid . Negative_regulation PRG4 IL1B 11007768 752579 Human chondrocytes that overexpressed IL-1RII were resistant to IL-1 induced mRNA accumulation and *inhibition* of [proteoglycan] synthesis . Negative_regulation PRG4 IL1B 11457450 838164 15-deoxy-Delta12,14-prostaglandin J2 ( 15d-PGJ2 ) , in contrast to troglitazone , was highly potent to counteract *induced* cyclooxygenase-2 and inductible nitric oxide synthase expression , NO production and the decrease in [proteoglycan] synthesis . Negative_regulation PRG4 IL1B 12096231 960892 Both PBMC and plus TNF-alpha *induced* strong inhibition of cartilage [proteoglycan] synthesis and significant enhancement of the release of proteoglycans , diminishing proteoglycan content . Negative_regulation PRG4 IL1B 14499180 1143654 stimulated the release of matrix sulfated proteoglycans in the culture medium , and significantly *inhibited* sulfated [proteoglycan] synthesis . Negative_regulation PRG4 IL1B 9416852 472216 The present study was conducted to determine whether stimulation of human articular chondrocytes with OP-1 can help overcome *induced* suppression of [35S-proteoglycan] synthesis . Negative_regulation PRG4 IL1B 9416852 472219 at 10 pg/ml *caused* a 60 % decrease in [35S-proteoglycan] synthesis . Negative_regulation PRG4 MAP2K6 15801908 1432386 Instead , in alginate- cultured chondrocytes , the inhibitors *increased* IGF-I stimulated [proteoglycan] synthesis when compared with cells treated with IGF-I alone . Negative_regulation PRG4 MAP2K6 19762915 2158822 Lentivirus mediated overexpression of constitutively active ( CA ) Akt significantly enhanced proteoglycan synthesis , whereas both dominant negative Akt and CA *inhibited* [proteoglycan] synthesis . Negative_regulation PRG4 MMP28 10525477 654097 The Fn-fs up-regulate expression , significantly *enhance* degradation and loss of [proteoglycan (PG)] from cartilage and temporarily suppress PG synthesis , all events observed in OA . Negative_regulation PRG4 MMP28 16563811 1582416 Inhibition of activity *reduced* both [proteoglycan] loss and type II collagen degradation . Negative_regulation PRG4 MMP7 10525477 654112 The Fn-fs up-regulate expression , significantly *enhance* degradation and loss of [proteoglycan (PG)] from cartilage and temporarily suppress PG synthesis , all events observed in OA . Negative_regulation PRG4 MMP7 16563811 1582431 Inhibition of activity *reduced* both [proteoglycan] loss and type II collagen degradation . Negative_regulation PRG4 S100B 9796780 543470 Here , it was demonstrated that 5-HT stimulates expression of cartilage [proteoglycan] core protein , and *inhibits* expression of and tenascin in mandibular explants . Negative_regulation PRG4 TNF 10857772 704545 ( 10 ng/ml ) stimulated [ 3H ] thymidine incorporation in undifferentiated ATDC5 cells , and *suppressed* cartilaginous nodule formation and the accumulation of cartilage-specific [proteoglycan] . Negative_regulation PRG4 TNF 11665971 872288 Additionally , CTS augments the reparative process via abrogation of *induced* suppression of [proteoglycan] synthesis . Negative_regulation PRG4 TNF 12096231 960891 Both PBMC and IL-1beta plus *induced* strong inhibition of cartilage [proteoglycan] synthesis and significant enhancement of the release of proteoglycans , diminishing proteoglycan content . Negative_regulation PRG4 TNF 15564062 1341378 *prevented* the mechanical stimulation of [proteoglycan] synthesis , and this effect was not dependent on NOS2 . Negative_regulation PRG4 TNF 1863822 164001 In both young and old human articular cartilage explants , *induced* a concentration dependent , reversible suppression of the [proteoglycan (PG)] synthesis . Negative_regulation PRG4 TNF 22038356 2499445 The result showed that increased the expression of ß-catenin and MMP-13 , and significantly *inhibited* the synthesis of type II collagen and [proteoglycan] , which resulted in the degeneration of nucleus pulposus cells . Negative_regulation PRG4 TNF 22776731 2627750 In contrast , *inhibited* [PRG4] expression , and this was partially alleviated by IHP . Negative_regulation PRG4 TNF 22776731 2627751 Our study demonstrates a beneficial role of IHP , which can be used successfully in combination with TGF-ß1 to enhance PRG4 production , and can partially counteract *induced* [PRG4] inhibition in isolated rat SFs . Negative_regulation PRG4 TNF 3498042 77903 also has been shown to cause similar cartilage degradation and both cytokines *inhibit* resynthesis of [proteoglycan] . Negative_regulation PRG4 TNF 3736671 62697 I report here that recombinant human stimulates resorption and *inhibits* synthesis of [proteoglycan] in explants of cartilage . Negative_regulation PRG4 TNF 7794042 313509 However , neutralising with a monoclonal antibody was effective in suppressing inflammatory changes in the joint during the acute onset of AIA , but it *had* little effect on the loss of [proteoglycan] from cartilage . Negative_regulation PRG4 TNF 7814444 292686 *reduces* [proteoglycan] synthesis in cultured endothelial cells . Negative_regulation PRG4 TNF 9770330 538829 In contrast , neutralization of IL-1 , but not , *resulted* in a significant decrease of chondrocyte [proteoglycan] synthesis inhibition . Negative_regulation PRKAA1 AXIN2 24093678 2852001 Importantly , adenovirus based knockdown of AXIN in the mouse liver impaired AMPK activation and caused exacerbated fatty liver after starvation , underscoring an essential *role* of in [AMPK] activation . Negative_regulation PRKAA1 EPHB2 15558058 1343422 In cultures of cardiac myocytes , adiponectin activated [AMPK] and *inhibited* agonist stimulated hypertrophy and activation . Negative_regulation PRKAA1 EPHB2 21666115 2470864 Thus APN inhibits ROS induced cardiomyocyte remodeling by activating [AMPK] and *inhibiting* signaling and NF-?B activity . Negative_regulation PRKAA1 FAS 17409402 1722192 This indicates that substrate accumulation from *inhibition* triggering [AMPK] activation , not end-product depletion of fatty acids , is likely responsible for AMPK activation . Negative_regulation PRKAA1 FAS 17409402 1722198 Thus , pharmacologic inhibition selectively *activates* [AMPK] in ovarian cancer cells , inducing cytotoxicity while sparing most normal human tissues from the pleiotropic effects of AMPK activation . Negative_regulation PRKAA1 MAP2K6 22012952 2526923 P13K inhibitor LY294002 and Akt1/2 kinase inhibitor but not the ERK1/2 kinase ( ) inhibitors PD98059 and U0126 *blocked* the insulin induced reduction in AdipoR1 expression and [AMPK] phosphorylation . Negative_regulation PRKAA1 NT5E 21873433 2486586 We hypothesized that gene silencing of enzymes to increase the intracellular availability of AMP would *increase* [AMP activated protein kinase (AMPK)] activity and metabolism . Negative_regulation PRKAA1 TCN1 23018889 2720374 Furthermore , whereas Compound C ( an AMPK inhibitor ) , AMPK-DN ( AMPK-dominant negative ) mutant , and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA *inhibited* the 8-Cl-cAMP- and AICAR mediated phosphorylation of [AMPK] and p38 MAPK . Negative_regulation PRKAA2 AXIN2 24093678 2852003 Importantly , adenovirus based knockdown of AXIN in the mouse liver impaired AMPK activation and caused exacerbated fatty liver after starvation , underscoring an essential *role* of in [AMPK] activation . Negative_regulation PRKAA2 EPHB2 15558058 1343423 In cultures of cardiac myocytes , adiponectin activated [AMPK] and *inhibited* agonist stimulated hypertrophy and activation . Negative_regulation PRKAA2 EPHB2 21666115 2470865 Thus APN inhibits ROS induced cardiomyocyte remodeling by activating [AMPK] and *inhibiting* signaling and NF-?B activity . Negative_regulation PRKAA2 FAS 17409402 1722193 This indicates that substrate accumulation from *inhibition* triggering [AMPK] activation , not end-product depletion of fatty acids , is likely responsible for AMPK activation . Negative_regulation PRKAA2 FAS 17409402 1722199 Thus , pharmacologic inhibition selectively *activates* [AMPK] in ovarian cancer cells , inducing cytotoxicity while sparing most normal human tissues from the pleiotropic effects of AMPK activation . Negative_regulation PRKAA2 MAP2K6 22012952 2526934 P13K inhibitor LY294002 and Akt1/2 kinase inhibitor but not the ERK1/2 kinase ( ) inhibitors PD98059 and U0126 *blocked* the insulin induced reduction in AdipoR1 expression and [AMPK] phosphorylation . Negative_regulation PRKAA2 NT5E 21873433 2486587 We hypothesized that gene silencing of enzymes to increase the intracellular availability of AMP would *increase* [AMP activated protein kinase (AMPK)] activity and metabolism . Negative_regulation PRKAA2 TCN1 23018889 2720376 Furthermore , whereas Compound C ( an AMPK inhibitor ) , AMPK-DN ( AMPK-dominant negative ) mutant , and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA *inhibited* the 8-Cl-cAMP- and AICAR mediated phosphorylation of [AMPK] and p38 MAPK . Negative_regulation PRKAB1 AXIN2 24093678 2852005 Importantly , adenovirus based knockdown of AXIN in the mouse liver impaired AMPK activation and caused exacerbated fatty liver after starvation , underscoring an essential *role* of in [AMPK] activation . Negative_regulation PRKAB1 EPHB2 15558058 1343424 In cultures of cardiac myocytes , adiponectin activated [AMPK] and *inhibited* agonist stimulated hypertrophy and activation . Negative_regulation PRKAB1 EPHB2 21666115 2470866 Thus APN inhibits ROS induced cardiomyocyte remodeling by activating [AMPK] and *inhibiting* signaling and NF-?B activity . Negative_regulation PRKAB1 FAS 17409402 1722194 This indicates that substrate accumulation from *inhibition* triggering [AMPK] activation , not end-product depletion of fatty acids , is likely responsible for AMPK activation . Negative_regulation PRKAB1 FAS 17409402 1722200 Thus , pharmacologic inhibition selectively *activates* [AMPK] in ovarian cancer cells , inducing cytotoxicity while sparing most normal human tissues from the pleiotropic effects of AMPK activation . Negative_regulation PRKAB1 MAP2K6 22012952 2526945 P13K inhibitor LY294002 and Akt1/2 kinase inhibitor but not the ERK1/2 kinase ( ) inhibitors PD98059 and U0126 *blocked* the insulin induced reduction in AdipoR1 expression and [AMPK] phosphorylation . Negative_regulation PRKAB1 NT5E 21873433 2486588 We hypothesized that gene silencing of enzymes to increase the intracellular availability of AMP would *increase* [AMP activated protein kinase (AMPK)] activity and metabolism . Negative_regulation PRKAB1 TCN1 23018889 2720378 Furthermore , whereas Compound C ( an AMPK inhibitor ) , AMPK-DN ( AMPK-dominant negative ) mutant , and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA *inhibited* the 8-Cl-cAMP- and AICAR mediated phosphorylation of [AMPK] and p38 MAPK . Negative_regulation PRKAB2 AXIN2 24093678 2852007 Importantly , adenovirus based knockdown of AXIN in the mouse liver impaired AMPK activation and caused exacerbated fatty liver after starvation , underscoring an essential *role* of in [AMPK] activation . Negative_regulation PRKAB2 EPHB2 15558058 1343425 In cultures of cardiac myocytes , adiponectin activated [AMPK] and *inhibited* agonist stimulated hypertrophy and activation . Negative_regulation PRKAB2 EPHB2 21666115 2470867 Thus APN inhibits ROS induced cardiomyocyte remodeling by activating [AMPK] and *inhibiting* signaling and NF-?B activity . Negative_regulation PRKAB2 FAS 17409402 1722195 This indicates that substrate accumulation from *inhibition* triggering [AMPK] activation , not end-product depletion of fatty acids , is likely responsible for AMPK activation . Negative_regulation PRKAB2 FAS 17409402 1722201 Thus , pharmacologic inhibition selectively *activates* [AMPK] in ovarian cancer cells , inducing cytotoxicity while sparing most normal human tissues from the pleiotropic effects of AMPK activation . Negative_regulation PRKAB2 MAP2K6 22012952 2526956 P13K inhibitor LY294002 and Akt1/2 kinase inhibitor but not the ERK1/2 kinase ( ) inhibitors PD98059 and U0126 *blocked* the insulin induced reduction in AdipoR1 expression and [AMPK] phosphorylation . Negative_regulation PRKAB2 NT5E 21873433 2486589 We hypothesized that gene silencing of enzymes to increase the intracellular availability of AMP would *increase* [AMP activated protein kinase (AMPK)] activity and metabolism . Negative_regulation PRKAB2 TCN1 23018889 2720380 Furthermore , whereas Compound C ( an AMPK inhibitor ) , AMPK-DN ( AMPK-dominant negative ) mutant , and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA *inhibited* the 8-Cl-cAMP- and AICAR mediated phosphorylation of [AMPK] and p38 MAPK . Negative_regulation PRKACB EPHB2 19741198 2152992 In contrast , in the absence of GPR30 expression in cultured VSMC , estradiol stimulated [PKA] activity and *inhibited* phosphorylation . Negative_regulation PRKACB EPHB2 21701568 2505155 We found that SAA increased the phosphorylation of perilipin and hormone-sensitive lipase (HSL) after 12-h treatment and decreased perilipin expression after 24-h treatment , and these effects were prevented by extracellular signal regulated kinase ( ) or [protein kinase A (PKA)] *inhibitors* in primary adipocyte cell culture . Negative_regulation PRKACB EPHB2 24842369 2940260 In contradiction to previous in vitro studies that showed ERK activation by prostaglandin E2 ( PGE2 ) engagement with prostaglandin receptor EP4 , intravenous administration of EP4 agonist activated [PKA] , *inhibited* , and suppressed migration of neutrophils . Negative_regulation PRKACB FOXO1 22342903 2668715 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by [PKA] or silencing mediator of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation PRKACB IL1B 8872964 389802 Unexpectedly , the inhibitory action of PKA was not through cAMP response element ( CRE ) but through TRE , because ( i ) activation of CRE was not induced by , and ( ii ) cAMP mediated activation of [PKA] *suppressed* the basal TRE activity . Negative_regulation PRKACB PDE4B 21266552 2414452 The SAM mediated decrease in LPS-inducible up-regulation *resulted* in an increase in cellular cAMP levels and activation of cAMP dependent [protein kinase A (PKA)] , which plays an inhibitory role in LPS induced TNF production . Negative_regulation PRKACB TNF 19150610 2043115 Although H89 can inhibit both MSK1 and PKA , does not *activate* [PKA] ( EC 2.7.11.11 ) and as such PKA inhibition does not mediate H89 instigated repression of TNF stimulated gene expression . Negative_regulation PRKACG EPHB2 19741198 2152993 In contrast , in the absence of GPR30 expression in cultured VSMC , estradiol stimulated [PKA] activity and *inhibited* phosphorylation . Negative_regulation PRKACG EPHB2 21701568 2505156 We found that SAA increased the phosphorylation of perilipin and hormone-sensitive lipase (HSL) after 12-h treatment and decreased perilipin expression after 24-h treatment , and these effects were prevented by extracellular signal regulated kinase ( ) or [protein kinase A (PKA)] *inhibitors* in primary adipocyte cell culture . Negative_regulation PRKACG EPHB2 24842369 2940261 In contradiction to previous in vitro studies that showed ERK activation by prostaglandin E2 ( PGE2 ) engagement with prostaglandin receptor EP4 , intravenous administration of EP4 agonist activated [PKA] , *inhibited* , and suppressed migration of neutrophils . Negative_regulation PRKACG FOXO1 22342903 2668722 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by [PKA] or silencing mediator of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation PRKACG IL1B 8872964 389803 Unexpectedly , the inhibitory action of PKA was not through cAMP response element ( CRE ) but through TRE , because ( i ) activation of CRE was not induced by , and ( ii ) cAMP mediated activation of [PKA] *suppressed* the basal TRE activity . Negative_regulation PRKACG PDE4B 21266552 2414453 The SAM mediated decrease in LPS-inducible up-regulation *resulted* in an increase in cellular cAMP levels and activation of cAMP dependent [protein kinase A (PKA)] , which plays an inhibitory role in LPS induced TNF production . Negative_regulation PRKACG TNF 19150610 2043116 Although H89 can inhibit both MSK1 and PKA , does not *activate* [PKA] ( EC 2.7.11.11 ) and as such PKA inhibition does not mediate H89 instigated repression of TNF stimulated gene expression . Negative_regulation PRKAG1 AXIN2 24093678 2852009 Importantly , adenovirus based knockdown of AXIN in the mouse liver impaired AMPK activation and caused exacerbated fatty liver after starvation , underscoring an essential *role* of in [AMPK] activation . Negative_regulation PRKAG1 EPHB2 15558058 1343426 In cultures of cardiac myocytes , adiponectin activated [AMPK] and *inhibited* agonist stimulated hypertrophy and activation . Negative_regulation PRKAG1 EPHB2 21666115 2470868 Thus APN inhibits ROS induced cardiomyocyte remodeling by activating [AMPK] and *inhibiting* signaling and NF-?B activity . Negative_regulation PRKAG1 FAS 17409402 1722196 This indicates that substrate accumulation from *inhibition* triggering [AMPK] activation , not end-product depletion of fatty acids , is likely responsible for AMPK activation . Negative_regulation PRKAG1 FAS 17409402 1722202 Thus , pharmacologic inhibition selectively *activates* [AMPK] in ovarian cancer cells , inducing cytotoxicity while sparing most normal human tissues from the pleiotropic effects of AMPK activation . Negative_regulation PRKAG1 MAP2K6 22012952 2526967 P13K inhibitor LY294002 and Akt1/2 kinase inhibitor but not the ERK1/2 kinase ( ) inhibitors PD98059 and U0126 *blocked* the insulin induced reduction in AdipoR1 expression and [AMPK] phosphorylation . Negative_regulation PRKAG1 NT5E 21873433 2486590 We hypothesized that gene silencing of enzymes to increase the intracellular availability of AMP would *increase* [AMP activated protein kinase (AMPK)] activity and metabolism . Negative_regulation PRKAG1 TCN1 23018889 2720382 Furthermore , whereas Compound C ( an AMPK inhibitor ) , AMPK-DN ( AMPK-dominant negative ) mutant , and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA *inhibited* the 8-Cl-cAMP- and AICAR mediated phosphorylation of [AMPK] and p38 MAPK . Negative_regulation PRKAG2 AXIN2 24093678 2852011 Importantly , adenovirus based knockdown of AXIN in the mouse liver impaired AMPK activation and caused exacerbated fatty liver after starvation , underscoring an essential *role* of in [AMPK] activation . Negative_regulation PRKAG2 EPHB2 15558058 1343427 In cultures of cardiac myocytes , adiponectin activated [AMPK] and *inhibited* agonist stimulated hypertrophy and activation . Negative_regulation PRKAG2 EPHB2 21666115 2470869 Thus APN inhibits ROS induced cardiomyocyte remodeling by activating [AMPK] and *inhibiting* signaling and NF-?B activity . Negative_regulation PRKAG2 FAS 17409402 1722197 This indicates that substrate accumulation from *inhibition* triggering [AMPK] activation , not end-product depletion of fatty acids , is likely responsible for AMPK activation . Negative_regulation PRKAG2 FAS 17409402 1722203 Thus , pharmacologic inhibition selectively *activates* [AMPK] in ovarian cancer cells , inducing cytotoxicity while sparing most normal human tissues from the pleiotropic effects of AMPK activation . Negative_regulation PRKAG2 MAP2K6 22012952 2526978 P13K inhibitor LY294002 and Akt1/2 kinase inhibitor but not the ERK1/2 kinase ( ) inhibitors PD98059 and U0126 *blocked* the insulin induced reduction in AdipoR1 expression and [AMPK] phosphorylation . Negative_regulation PRKAG2 NT5E 21873433 2486591 We hypothesized that gene silencing of enzymes to increase the intracellular availability of AMP would *increase* [AMP activated protein kinase (AMPK)] activity and metabolism . Negative_regulation PRKAG2 TCN1 23018889 2720384 Furthermore , whereas Compound C ( an AMPK inhibitor ) , AMPK-DN ( AMPK-dominant negative ) mutant , and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA *inhibited* the 8-Cl-cAMP- and AICAR mediated phosphorylation of [AMPK] and p38 MAPK . Negative_regulation PRKAR1A EPHB2 19741198 2152994 In contrast , in the absence of GPR30 expression in cultured VSMC , estradiol stimulated [PKA] activity and *inhibited* phosphorylation . Negative_regulation PRKAR1A EPHB2 21701568 2505157 We found that SAA increased the phosphorylation of perilipin and hormone-sensitive lipase (HSL) after 12-h treatment and decreased perilipin expression after 24-h treatment , and these effects were prevented by extracellular signal regulated kinase ( ) or [protein kinase A (PKA)] *inhibitors* in primary adipocyte cell culture . Negative_regulation PRKAR1A EPHB2 24842369 2940262 In contradiction to previous in vitro studies that showed ERK activation by prostaglandin E2 ( PGE2 ) engagement with prostaglandin receptor EP4 , intravenous administration of EP4 agonist activated [PKA] , *inhibited* , and suppressed migration of neutrophils . Negative_regulation PRKAR1A FOXO1 22342903 2668795 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by [PKA] or silencing mediator of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation PRKAR1A IL1B 8872964 389804 Unexpectedly , the inhibitory action of PKA was not through cAMP response element ( CRE ) but through TRE , because ( i ) activation of CRE was not induced by , and ( ii ) cAMP mediated activation of [PKA] *suppressed* the basal TRE activity . Negative_regulation PRKAR1A PDE4B 21266552 2414454 The SAM mediated decrease in LPS-inducible up-regulation *resulted* in an increase in cellular cAMP levels and activation of cAMP dependent [protein kinase A (PKA)] , which plays an inhibitory role in LPS induced TNF production . Negative_regulation PRKAR1A TNF 19150610 2043117 Although H89 can inhibit both MSK1 and PKA , does not *activate* [PKA] ( EC 2.7.11.11 ) and as such PKA inhibition does not mediate H89 instigated repression of TNF stimulated gene expression . Negative_regulation PRKAR1B EPHB2 19741198 2152995 In contrast , in the absence of GPR30 expression in cultured VSMC , estradiol stimulated [PKA] activity and *inhibited* phosphorylation . Negative_regulation PRKAR1B EPHB2 21701568 2505158 We found that SAA increased the phosphorylation of perilipin and hormone-sensitive lipase (HSL) after 12-h treatment and decreased perilipin expression after 24-h treatment , and these effects were prevented by extracellular signal regulated kinase ( ) or [protein kinase A (PKA)] *inhibitors* in primary adipocyte cell culture . Negative_regulation PRKAR1B EPHB2 24842369 2940263 In contradiction to previous in vitro studies that showed ERK activation by prostaglandin E2 ( PGE2 ) engagement with prostaglandin receptor EP4 , intravenous administration of EP4 agonist activated [PKA] , *inhibited* , and suppressed migration of neutrophils . Negative_regulation PRKAR1B FOXO1 22342903 2668802 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by [PKA] or silencing mediator of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation PRKAR1B IL1B 8872964 389805 Unexpectedly , the inhibitory action of PKA was not through cAMP response element ( CRE ) but through TRE , because ( i ) activation of CRE was not induced by , and ( ii ) cAMP mediated activation of [PKA] *suppressed* the basal TRE activity . Negative_regulation PRKAR1B PDE4B 21266552 2414455 The SAM mediated decrease in LPS-inducible up-regulation *resulted* in an increase in cellular cAMP levels and activation of cAMP dependent [protein kinase A (PKA)] , which plays an inhibitory role in LPS induced TNF production . Negative_regulation PRKAR1B TNF 19150610 2043118 Although H89 can inhibit both MSK1 and PKA , does not *activate* [PKA] ( EC 2.7.11.11 ) and as such PKA inhibition does not mediate H89 instigated repression of TNF stimulated gene expression . Negative_regulation PRKAR2A EPHB2 19741198 2152996 In contrast , in the absence of GPR30 expression in cultured VSMC , estradiol stimulated [PKA] activity and *inhibited* phosphorylation . Negative_regulation PRKAR2A EPHB2 21701568 2505159 We found that SAA increased the phosphorylation of perilipin and hormone-sensitive lipase (HSL) after 12-h treatment and decreased perilipin expression after 24-h treatment , and these effects were prevented by extracellular signal regulated kinase ( ) or [protein kinase A (PKA)] *inhibitors* in primary adipocyte cell culture . Negative_regulation PRKAR2A EPHB2 24842369 2940264 In contradiction to previous in vitro studies that showed ERK activation by prostaglandin E2 ( PGE2 ) engagement with prostaglandin receptor EP4 , intravenous administration of EP4 agonist activated [PKA] , *inhibited* , and suppressed migration of neutrophils . Negative_regulation PRKAR2A FOXO1 22342903 2668809 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by [PKA] or silencing mediator of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation PRKAR2A IL1B 8872964 389806 Unexpectedly , the inhibitory action of PKA was not through cAMP response element ( CRE ) but through TRE , because ( i ) activation of CRE was not induced by , and ( ii ) cAMP mediated activation of [PKA] *suppressed* the basal TRE activity . Negative_regulation PRKAR2A PDE4B 21266552 2414456 The SAM mediated decrease in LPS-inducible up-regulation *resulted* in an increase in cellular cAMP levels and activation of cAMP dependent [protein kinase A (PKA)] , which plays an inhibitory role in LPS induced TNF production . Negative_regulation PRKAR2A TNF 19150610 2043119 Although H89 can inhibit both MSK1 and PKA , does not *activate* [PKA] ( EC 2.7.11.11 ) and as such PKA inhibition does not mediate H89 instigated repression of TNF stimulated gene expression . Negative_regulation PRKAR2B EPHB2 19741198 2152997 In contrast , in the absence of GPR30 expression in cultured VSMC , estradiol stimulated [PKA] activity and *inhibited* phosphorylation . Negative_regulation PRKAR2B EPHB2 21701568 2505160 We found that SAA increased the phosphorylation of perilipin and hormone-sensitive lipase (HSL) after 12-h treatment and decreased perilipin expression after 24-h treatment , and these effects were prevented by extracellular signal regulated kinase ( ) or [protein kinase A (PKA)] *inhibitors* in primary adipocyte cell culture . Negative_regulation PRKAR2B EPHB2 24842369 2940265 In contradiction to previous in vitro studies that showed ERK activation by prostaglandin E2 ( PGE2 ) engagement with prostaglandin receptor EP4 , intravenous administration of EP4 agonist activated [PKA] , *inhibited* , and suppressed migration of neutrophils . Negative_regulation PRKAR2B FOXO1 22342903 2668816 Adiponectin levels are also stimulated by and AMP activated protein kinase (AMPK) , and are *suppressed* by [PKA] or silencing mediator of retinoid and thyroid hormone receptors ( SMRT ) . Negative_regulation PRKAR2B IL1B 8872964 389807 Unexpectedly , the inhibitory action of PKA was not through cAMP response element ( CRE ) but through TRE , because ( i ) activation of CRE was not induced by , and ( ii ) cAMP mediated activation of [PKA] *suppressed* the basal TRE activity . Negative_regulation PRKAR2B PDE4B 21266552 2414457 The SAM mediated decrease in LPS-inducible up-regulation *resulted* in an increase in cellular cAMP levels and activation of cAMP dependent [protein kinase A (PKA)] , which plays an inhibitory role in LPS induced TNF production . Negative_regulation PRKAR2B TNF 19150610 2043120 Although H89 can inhibit both MSK1 and PKA , does not *activate* [PKA] ( EC 2.7.11.11 ) and as such PKA inhibition does not mediate H89 instigated repression of TNF stimulated gene expression . Negative_regulation PRKCA TNF 10887171 730498 In L929 murine fibroblasts , ( 0.5- 5 nm ) *caused* potent inhibition of [PKC alpha] activity and induced translocation of PKC alpha from the cytosol to the membrane . Negative_regulation PRKCD EPHB2 19356729 2081126 Exposure to celastrol inhibited the interaction between immunoglobulin Fc epsilon receptor I ( FcepsilonRIgamma ) and and *inhibited* interaction between FcepsilonRIgamma and [protein kinase C delta (PKCdelta)] . Negative_regulation PRKDC EPHB2 23098854 2717292 Consistent with the activation of DNA-PKcs being required for NHEJ , we demonstrated that inhibition of activation using U0126 , MEK1K97M , and knockdown of ERK1 or ERK2 *enhanced* ETOP induced activation of [DNA-PKcs] . Negative_regulation PRKDC EPHB2 23098854 2717293 Conversely , enforcing activation by MEK1Q56P *reduced* ETOP initiated [DNA-PKcs] activation . Negative_regulation PRL ARSA 8445988 213902 Thus , deficiency *enhanced* the stimulated , but not the basal , secretion of [PRL] in ODS rats . Negative_regulation PRL EDN2 8344196 226318 *inhibits* basal and stimulated release of [prolactin] by human decidual cells . Negative_regulation PRL FOXO1 16690806 1584261 Silencing of using small interfering RNA oligonucleotides decreased IGFBP1 and DCN levels and *increased* CNR1 , TIMP3 , and [PRL] levels . Negative_regulation PRL FOXO1 17640988 1793165 Moreover , overexpression of SGK1 in decidualizing cells enhanced phosphorylation and cytoplasmic translocation of the forkhead transcription factor and *inhibited* the expression of [PRL] , a major decidual marker gene . Negative_regulation PRL FOXO1 22072736 2534173 Overexpression of triple-mutant *increased* mRNA levels of IGFBP1 and [PRL] in OsisSC in the presence of M+A , whereas the overexpression of wild-type FOXO1 had no effect . Negative_regulation PRL IL1B 2556147 122086 *inhibition* of TRH stimulated [prolactin] secretion and phosphoinositides metabolism . Negative_regulation PRL IL1B 2556147 122089 significantly *inhibited* TRH stimulated [prolactin] secretion assessed by the reverse hemolytic plaque assay . Negative_regulation PRL IL1B 2556147 122091 This study shows that *reduces* TRH induced [prolactin] secretion through a direct action on pituitary cell , and attenuates the TRH stimulated phosphoinositide breakdown . Negative_regulation PRL MAP2K6 19350575 2057637 and JNK inhibitors *suppressed* [PRL-] or PRL-plus-IL-17 induced CCL20 production and AP-1 activities . Negative_regulation PRL NGFR 10606728 575141 Anandamide ( ANA ) *inhibits* [prolactin-] and nerve growth factor (NGF) induced proliferation of human breast cancer cells by decreasing the levels of the 100 kDa prolactin receptor (PRLr) and the high affinity trk , respectively , and by acting via CB(1)-like cannabinoid receptors . Negative_regulation PRL TNF 12193577 981359 We previously reported that *reduces* anterior pituitary cell proliferation and [PRL] release in an estrogen dependent manner . Negative_regulation PRL TNF 2122738 143926 and interferon-gamma *reduce* [prolactin] release in vitro . Negative_regulation PRL TNF 2122738 143928 Overall [prolactin] accumulation during this first 24 h was *inhibited* by and markedly reduced by TNF-alpha plus IFN-gamma . Negative_regulation PRL TNF 2163305 136001 Similarly , *inhibited* the stimulated release of GH ( 100 % inhibition ) , LH ( 35 % inhibition ) , and [PRL] ( 100 % inhibition ) . Negative_regulation PRL TNF 2163305 136002 had no effect on the basal secretion of GH or LH but *inhibited* basal [PRL] in a dose dependent manner . Negative_regulation PRL TNF 7479297 331852 also *suppressed* basal [PRL] release and completely abolished the PRL response to TRH ( 0.1-10 nM ) . Negative_regulation PRL TNF 7479297 331854 significantly *enhanced* the inhibitory effect of somatostatin on stimulated [PRL] release , but not on GH or TSH release . Negative_regulation PRL TNF 7714166 288612 Of these cytokines , significantly *suppressed* [prolactin] production in a dose dependent manner , with no apparent effect on cell number . Negative_regulation PRL TNF 7714166 288613 and IL-1 significantly *suppressed* cAMP stimulated [prolactin] production by endometrial stromal cells . Negative_regulation PRL TNF 7714166 288615 These results indicated that and IL-1 *suppress* both progesterone induced and cAMP mediated [prolactin] production in endometrial stromal cells , and that this inhibition was not attributable to direct effects on progesterone metabolism or related to Ca ( 2+ ) -mediated signal transduction . Negative_regulation PRL TNF 8275950 247186 *inhibits* the synthesis and release of human decidual [prolactin] . Negative_regulation PRL TNF 9741828 532164 The presence of lipopolysaccharide ( LPS , 0.1 microg/mL ) in the culture medium significantly increased release and *inhibited* [prolactin] release . Negative_regulation PRL TNF 9741828 532166 The presence of ( 50 ng/mL ) in the culture medium *inhibited* [prolactin] release from anterior pituitary cells . Negative_regulation PRM1 TNF 10330036 614022 In an effort to elucidate the mechanism of gene inactivation , we report in this study that cationic [lipid-protamine-DNA] ( LPD ) complexes , but not each component alone , can *induce* a high level of cytokine production , including interferon-gamma and . Negative_regulation PRM2 TNF 10330036 614024 In an effort to elucidate the mechanism of gene inactivation , we report in this study that cationic [lipid-protamine-DNA] ( LPD ) complexes , but not each component alone , can *induce* a high level of cytokine production , including interferon-gamma and . Negative_regulation PRM3 TNF 10330036 614020 In an effort to elucidate the mechanism of gene inactivation , we report in this study that cationic [lipid-protamine-DNA] ( LPD ) complexes , but not each component alone , can *induce* a high level of cytokine production , including interferon-gamma and . Negative_regulation PRNP TNF 8790403 380920 To clarify the *role* of in experimental [CJD] , we investigated the expression of TNF-alpha in brain tissues from CJD virus infected mice at weekly intervals after inoculation by reverse transcription coupled PCR , Northern and Western blot analyses , and immunocytochemical staining . Negative_regulation PROC PLAT 1737024 181847 An amount of PIXI which inhibited by 50 % factor XIa cleavage of the chromogenic substrate S2366 ( Pyr-Glu-Pro-Arg-pNA-2H2O ) only slightly inhibited ( 5-9 % ) factor XIIa , plasma kallikrein , plasmin , and [activated protein C] and did not *inhibit* factor Xa , thrombin , , or trypsin , suggesting specificity for factor XIa . Negative_regulation PROC SERPINA5 10728028 678152 Since *inhibits* [activated protein C (APC)] and a number of proteases , one would expect lower concentrations of PCI in a hypercoagulable state due to increased consumption of the inhibitor . Negative_regulation PROC SERPINA5 8972021 402889 Heparin *stimulation* of the inhibition of [activated protein C] and other enzymes by human -- influence of the molecular weightof heparin and ionic strength . Negative_regulation PRODH MIR23B 22615405 2610409 *mediates* [POX/PRODH] down-regulation in human kidney tumors . Negative_regulation PRODH MYC 22615405 2610410 Using MYC-inducible human Burkitt lymphoma model P493 and PC3 human prostate cancer cells , we showed that *suppressed* [POX/PRODH] expression primarily through up-regulating miR-23b* . Negative_regulation PRODH MYC 22615405 2610411 Interestingly , not only *inhibited* [POX/PRODH] , but also markedly increased the enzymes of proline biosynthesis from glutamine , including P5C synthase and P5C reductase 1 . Negative_regulation PROKR1 TNF 17170518 1662242 Regulation of receptor expression also differed in BAEC and LEC : markedly *reduced* [PK-R1] only in BAEC , but serum removal decreased PK-R1 in both cell types . Negative_regulation PROM1 ANGPT1 22558265 2591216 Overexpression of resulted in a significant increase in CXCR-4/SDF-1a expression and *promoted* CD133 ( + ) /c-kit ( + ) , [CD133] ( + ) /CXCR-4 ( + ) and CD133 ( + ) /SDF-1a ( + ) cell recruitment into ischemic hearts . Negative_regulation PROM1 GPR87 23593389 2773477 In this study , we explored the *role* of in the regulation of [CD133] expression . Negative_regulation PROM1 GPR87 23593389 2773480 We demonstrated that the overexpression of *up-regulated* [CD133] expression , promoted CSC associated migratory and invasive properties in vitro , and increased tumor initiation in vivo . Negative_regulation PRS EDN2 23469133 2750247 To examine directly the *role* of in mutant [PRs] , we used a scAAV5-Edn2 cDNA vector to restore Edn2 expression in Pde6b ( rd1/rd1 ) ; Negative_regulation PRSS21 SRC 10698670 671902 We evaluated the *role* of tyrosine kinase in control and EGME treated adult rat [testis in] vivo , as well as in vitro using cultured adult rat seminiferous tubules treated with MAA . Negative_regulation PSD TNF 18986529 2001356 Results showed that although fish oil diet did not exert any effect upon these measurements , [PSD] *induced* a reduction in adiponectin gene expression of retroperitoneal adipose tissues , with no change in serum adiponectin concentration or in adiponectin and gene expression of epididymal adipose tissue . Negative_regulation PSENEN SORL1 19036982 1998686 Loss of *increases* the processing of the APP holo-molecule into alpha- , beta- , and [gamma-secretase] derived metabolites . Negative_regulation PSMG1 ARSA 22409214 2624378 In the *presence* of 50 µM , simvastatin and pravastatin significantly reduced the [PAC-1] expression ( 30 % reduction for simvastatin , P < 0·01 , and 15 % reduction for pravastatin , P < 0·01 ) , platelet aggregation ( 20 % reduction for both statins , P < 0·01 ) and thromboxane generation ( 35 % reduction for simvastatin , P < 0·001 , and 30 % reduction for pravastatin , P < 0·001 ) compared to ASA alone . Negative_regulation PSMG1 TNF 15570633 1344231 [PAC-1] binding was not *inhibited* by MTX or . Negative_regulation PTBP1 TLR7 18824534 1987746 Rather , it has been shown that helminth products such as soluble egg antigens ( SEA ; a soluble extract from Schistosoma mansoni eggs ) inhibit the activation of [DCs] in *response* to classical ligands such as lipopolysaccharide or CpG . Negative_regulation PTBP1 TLR7 23257360 2724748 Given the expansion of CD11c+ DCs during the progression of atherosclerosis and the key role of T cell activation in atherogenesis , we sought to understand the *role* of signaling in CD11c+ [DCs] in atherosclerosis . Negative_regulation PTBP1 TNF 14611814 1162833 Increasing enhanced the survival of culturing stem cells and *resulted* in a parallel increase in day 14 [DCs] . Negative_regulation PTBP1 TNF 20735407 2341631 Shikonin treated [BM-DCs] were poor stimulators of CD4 ( + ) T lymphocyte and *induced* lower levels of interleukin (IL)-4 , IL-5 , IL-13 and release by responding T-cells . Negative_regulation PTBP2 TLR7 18824534 1987716 Rather , it has been shown that helminth products such as soluble egg antigens ( SEA ; a soluble extract from Schistosoma mansoni eggs ) inhibit the activation of [DCs] in *response* to classical ligands such as lipopolysaccharide or CpG . Negative_regulation PTBP2 TLR7 23257360 2724718 Given the expansion of CD11c+ DCs during the progression of atherosclerosis and the key role of T cell activation in atherogenesis , we sought to understand the *role* of signaling in CD11c+ [DCs] in atherosclerosis . Negative_regulation PTBP2 TNF 14611814 1162830 Increasing enhanced the survival of culturing stem cells and *resulted* in a parallel increase in day 14 [DCs] . Negative_regulation PTBP2 TNF 20735407 2341622 Shikonin treated [BM-DCs] were poor stimulators of CD4 ( + ) T lymphocyte and *induced* lower levels of interleukin (IL)-4 , IL-5 , IL-13 and release by responding T-cells . Negative_regulation PTEN CCND1 23826727 2865801 A downregulation in p16(ink4a) occurs when [PTEN] is lost as a *result* of induction and the activation of E2F transcription factors . Negative_regulation PTEN EPHB2 19881543 2197184 UVB induced *dependent* [PTEN] suppression promotes survival of epidermal keratinocytes . Negative_regulation PTEN EPHB2 20147383 2208288 Loss of Alk5 mediated signaling also stimulated [Pten] gene expression and *inhibited* phosphorylation in vivo . Negative_regulation PTEN FAS 22949843 2667192 Upregulating [PTEN] expression and *inhibiting* expression may offer a novel therapeutic approach for HCC . Negative_regulation PTEN ID1 19079342 2030889 In promoter assay with serial deletion and chromatin immunoprecipitation assay , the binding of p53 to the [PTEN] promoter was *reduced* by , suggesting that Id-1 regulates PTEN transcription through its p53 modulation . Negative_regulation PTEN MAP2K6 22215152 2599781 This observation led to the identification of a novel crosstalk mechanism , by which either pharmacologic or genetic inhibition of constitutive signaling *restores* [phosphatase and tensin homolog (PTEN)] expression , both in vitro and in vivo , and inhibits downstream signaling through AKT and mTOR , thus bypassing the need for double pathway blockade . Negative_regulation PTEN TNF 14623898 1200886 In addition , overexpression of TNF-alpha downstream signaling targets , nuclear factor-kappaB (NF-kappaB) inducing kinase ( NIK ) and p65 nuclear factor NF-kappaB , lowers PTEN expression , suggesting that *induced* down-regulation of [PTEN] is mediated through a TNF-alpha/NIK/NF-kappaB pathway . Negative_regulation PTEN TNF 14729949 1198652 Importantly , , a potent inducer of NF-kappa B activity , *suppressed* [PTEN] gene expression in IKK beta ( +/+ ) cells but not in IKK beta ( -/- ) cells , which are deficient in the NF-kappa B activation pathway . Negative_regulation PTEN TNF 14984207 1214667 Furthermore , [PTEN] expression strongly decreased MMP-9 promoter activity in *response* to . Negative_regulation PTEN TNF 19593846 2105383 Quantitative real-time PCR assays showed that CE treatment decreased the mRNA expression of IL-1beta , IL-6 and , improved the mRNA expression of IR , IRS1 , IRS2 , PI3K and Akt1 , *inhibited* CD36 , MTTP , and [PTEN] , and enhanced the impaired SREBP-1c expression in TNF-alpha treated enterocytes . Negative_regulation PTGDR ADRB2 2880608 69576 These results suggest a *mediated* cyclic AMP dependent mechanism for the regulation of [prostaglandin D2 receptor] binding in rabbit platelets . Negative_regulation PTGER1 IL1B 9916962 587592 The results of this study show that might be *involved* in infection induced preterm labor by interfering with the normal regulation of [EP1] receptor levels and with the promotion of increased PGE2 production in amnion tissue . Negative_regulation PTGER2 ARRB2 11418617 849794 Signaling via endogenous EP4 receptors in CHO-K1 cells was attenuated by ARR2-GFP expression , whereas ( R169E ) -GFP expression in HASM *inhibited* [EP2] receptor mediated cAMP production . Negative_regulation PTGER2 MNX1 23048027 2702736 Expression of *represses* [PTGER2] mediated signaling . Negative_regulation PTGER2 PTGER3 16666972 126581 [EP2] is inhibited by phenylmethylsulfonylfluoride , and both EP2 and are *inhibited* by the heavy metal chelators 1,10-phenanthroline and EDTA . Negative_regulation PTGER2 PTGER3 20939055 2401537 [EP2] and EP4 *induce* bone formation through the protein kinase A (PKA) pathway , whereas inhibits bone formation in vitro . Negative_regulation PTGER2 RORC 24812667 2939860 Decreased *dependent* silencing of prostaglandin receptor [EP2] induces autoimmune Th17 cells . Negative_regulation PTGER2 SPAG11B 16666972 126580 [EP2] is inhibited by phenylmethylsulfonylfluoride , and both and EP3 are *inhibited* by the heavy metal chelators 1,10-phenanthroline and EDTA . Negative_regulation PTGER2 TIMP1 20713758 2306633 Polymerase chain reaction analysis of transforming growth factor-beta1b , insulinlike growth factor (IGF)-1 , matrix metalloproteinase (MMP)-7 , MMP-9 , tissue *inhibitor* of metalloproteinase 1 ( ) , and [prostaglandin E receptor] EP4 expression was performed as well . Negative_regulation PTGER2 TNF 15075356 1265794 Synovial cells from mice with pristane induced arthritis ( DBA/1 ) also expressed [EP2/4] , and the EP2/4 agonist *inhibited* production . Negative_regulation PTGER3 PTGER2 16666972 126582 is inhibited by phenylmethylsulfonylfluoride , and both EP2 and [EP3] are *inhibited* by the heavy metal chelators 1,10-phenanthroline and EDTA . Negative_regulation PTGER4 EPHB2 17401137 1748626 The [EP4] agonist induced endothelial cell migration was *inhibited* by , but not PKA inhibitors , defining a functional link between PGE ( 2 ) -induced endothelial cell migration and EP4 mediated ERK signaling . Negative_regulation PTGER4 IL1B 15833737 1417992 Calu-3 expresses [EP4] receptors , but not EP2 , and receptor expression is *reduced* by . Negative_regulation PTGES ALOX5 24315851 2904894 The n-hexane extract of M. pinnata efficiently suppressed <5-LO> activity in stimulated human neutrophils ( IC50 =8.7µg/ml ) and potently *inhibited* isolated human recombinant 5-LO ( IC50 =0.48µg/ml ) and [mPGES-1] ( IC50 =1.0µg/ml ) . Negative_regulation PTGES TNF 14722058 1219627 also enhanced guanylate cyclase activity and inhibitors of guanylate cyclase activity *blocked* the induction of [mPGES-1] by TNF-alpha . Negative_regulation PTGES3 EPHB2 12223143 987663 HRT , VCR , and Vp16 could inhibit cell proliferation ( 0.28 % 0.08 % , 0.25 % 0.16 % , 0.24 % 0.11 % ) , induce apoptosis ( 21.12 % , 28.83 % , 12.30 % ) , *inhibit* [telomerase] activity , and down-regulate the protein expression of phosphorylated . Negative_regulation PTGES3 EPHB2 12674761 1030439 The results showed that HRT , VCR and Vp16 could inhibit cell proliferation , induce apoptosis , *inhibit* [telomerase] activity and down-regulate the protein expression of phosphorylated . Negative_regulation PTGES3 TNFSF10 23358473 2758702 In recent years , studies have shown that therapeutic agents such as metformin , salinomycin , DECA-14 , rapamycin , oncostatin M (OSM) , some natural compounds , oncolytic viruses , microRNAs , cell signaling pathway inhibitors , TNF related apoptosis inducing ligand ( ) , interferon ( IFN ) , [telomerase] *inhibitors* , all-trans retinoic acid ( ATRA ) and monoclonal antibodies can suppress the self-renewal of CSCs in vitro and in vivo . Negative_regulation PTGES3 ZFP57 20145034 2214638 The *repression* of [telomerase] expression by artificial targeting the promoter region of the hTERT presents a new promising strategy for inhibiting the growth of human cancer cells . Negative_regulation PTGS1 ARSA 16776633 1573089 The effectiveness of *mediated* inhibition of platelet [cyclooxygenase-1] was verified by determination of plasma thromboxane B ( 2 ) and urine 11-dehydro-thromboxane B ( 2 ) , accepted as reference assays for monitoring of ASA mediated platelet cyclooxygenase-1 inhibition . Negative_regulation PTGS1 ARSA 17508966 1745154 In a subpopulation of aspirin-sensitive *inhibition* of [COX-1] by nonsteroidal anti-inflammatory drugs results in activation of inflammatory cells and development of symptoms . Negative_regulation PTGS1 ARSA 17697012 1782215 Our results suggest that COX-2 activity is involved in ethanol induced HCV-RNA and NS5A protein expression , because , a [COX-1/2] *inhibitor* , blocked this induction and downregulated COX-2 protein expression and activity . Negative_regulation PTGS1 PTGER2 9779823 540435 Role of receptors and cAMP in prostaglandin E2 *regulated* expression of type I collagen alpha1 , lysyl oxidase , and [cyclooxygenase-1] genes in human embryo lung fibroblasts . Negative_regulation PTGS2 ARSA 11195467 761971 ( 294 mg/kg diet ) and NS398 also *inhibited* the expression of [COX-2] . Negative_regulation PTGS2 ARSA 15061569 1230543 *inhibits* COX-1 and converts [COX-2] into an ASA triggered lipid mediator generating system that produces an array of novel endogenous local autacoids from dietary omega-3 PUFA . Negative_regulation PTGS2 ARSA 15763541 1383550 *blocked* the expression of [cyclooxygenase-2] , the production of tumor necrosis factor-alpha and interleukin-6 , and the release of granule mediators from mast cells in a concentration dependent fashion . Negative_regulation PTGS2 ARSA 15763541 1383557 Interestingly , the expression of [cyclooxygenase-2] was not *inhibited* at 1mM , but was even enhanced significantly . Negative_regulation PTGS2 ARSA 17697012 1782216 Our results suggest that COX-2 activity is involved in ethanol induced HCV-RNA and NS5A protein expression , because , a [COX-1/2] *inhibitor* , blocked this induction and downregulated COX-2 protein expression and activity . Negative_regulation PTGS2 CCND1 17077316 1684058 Dexamethasone substantially reduced EGF stimulated [COX-2] expression at 3 and 6 h and expression at 8 and 12 h. Pretreatment of RGM-1 cells with dexamethasone or 2'-amino-3'-methoxyflavone ( PD98059 ) -mitogen activated protein kinase kinase inhibitor ( 5 x 10 ( -5 ) M ) significantly *reduced* EGF stimulated pERK1/pERK2 expression . Negative_regulation PTGS2 CTGF 21352962 2453147 *inhibits* cell motility and [COX-2] expression in oral cancer cells . Negative_regulation PTGS2 DAPK1 22465880 2588975 In addition , over-expression of from either TNF-a or INF-?-treatment cells *suppressed* the anti-apoptosis protein XIAP as well as [COX-2] and ICAM-1 , more than control . Negative_regulation PTGS2 EPHB2 10922992 717903 Inhibition of activation *had* no effect on [COX-2] expression . Negative_regulation PTGS2 EPHB2 11085935 750657 The potential *role* of in [PGHS-2] up-regulation was assessed by using cell lines expressing , both stably and after adenoviral infection , constitutively active forms of its upstream activator MAPK/ERK kinase ( MEK1 ) . Negative_regulation PTGS2 EPHB2 11439356 833222 The roles of p38 MAP kinases and in UVB *induced* [cox-2] gene expression were studied in a human keratinocyte cell line , HaCaT . Negative_regulation PTGS2 EPHB2 15780952 1385414 IL-1alpha activated phosphorylation and PD98059 greatly *inhibited* both [COX-2] mRNA expression and PGE ( 2 ) production induced by IL-1alpha in PDL cells . Negative_regulation PTGS2 EPHB2 17334414 1726562 Inhibition of activation , but not [cyclooxygenase-2] *inhibition* , completely abolished beneficial effect of G-CSF on cardiac function . Negative_regulation PTGS2 EPHB2 19135800 2037696 The [COX-2] induction was *prevented* by and p38 inhibitors . Negative_regulation PTGS2 EPHB2 22197135 2544123 Viscolin blocked the expression of iNOS and [COX-2] , and it also *inhibited* the for the activation of NF-?B in LPS stimulated RAW 264.7 macrophages . Negative_regulation PTGS2 EPHB2 23834707 2839022 Compound 10o was selective toward melanoma cell line subpanel , and its antiproliferative activity may be attributed to selective [cyclooxygenase-2] inhibition and pathway *inhibition* . Negative_regulation PTGS2 HBEGF 21244855 2414408 HB-EGF *enhanced* the expression of [COX-2] , a response mediated by MEK5-ERK5 signaling , while the COX-2 inhibitor rofecoxib attenuated induced ANF mRNA expression , suggesting that COX-2 is also associated with HB-EGF induced cardiomyocyte hypertrophy . Negative_regulation PTGS2 HSD11B2 15718388 1402864 We investigated whether medullary [COX-2] also *increases* in rats with <11betaHSD2> inhibition and examined its possible role in the development of hypertension . Negative_regulation PTGS2 IGFBP1 24378735 2921646 Furthermore , okadaic acid , a protein phosphatase (PP) 1/2A inhibitor , suppressed the progression of adipogenesis by preventing *mediated* suppression of CREB dependent [COX-2] expression , thus resulting in increased production of anti-adipogenic PGE2 and PGF2a . Negative_regulation PTGS2 IL1B 10924071 718166 These findings indicate that : 1 ) PMA , acting through PKC and p38 kinase , enhances [COX-2] expression , but chronic treatment with PMA partially *inhibits* stimulation of COX-2 ; Negative_regulation PTGS2 IL1B 10946846 721625 All HMG-CoA reductase inhibitors significantly reduced and -6 mRNA expression and their protein levels in the culture medium , and also *inhibited* [cyclooxygenase-2] mRNA expression and their protein levels . Negative_regulation PTGS2 IL1B 11260714 796243 Thus , preventing central prostanoid production by inhibiting the mediated induction of Cox-2 in neurons or by *inhibiting* central [Cox-2] activity reduces centrally generated inflammatory pain hypersensitivity . Negative_regulation PTGS2 IL1B 11530235 853792 However , rotenone inhibited NOS-2 and COX-2 proteins and associated nitric oxide and prostaglandin E ( 2 ) production , respectively , suggesting a posttranscriptional target for *mediated* regulation of NOS-2 and [COX-2] gene expression . Negative_regulation PTGS2 IL1B 11854442 913950 Moreover , stimulation of the cells caused the phosphorylation of p38 and extracellular signal regulated kinase ( ERK ) , and IL-1 beta induced [COX-2] expression was *inhibited* by the pretreatment of WISH cells with a p38 inhibitor , in contrast ERK upstream inhibitor had no effect . Negative_regulation PTGS2 IL1B 11971025 933508 We found that PPAR alpha ligands ( clofibrate and WY14643 ) *enhanced* IL-1 beta induced [COX-2] expression in human astrocytes and microglia , while inhibiting plus IFN-gamma induction of iNOS in astrocytes . Negative_regulation PTGS2 IL1B 15685372 1370973 L-NMMA *inhibited* induced promoter activity , gene transcription and protein expression of [COX-2] in pancreatic beta-cells . Negative_regulation PTGS2 IL1B 17510310 1745189 Using RNA interference , we have reduced the expression of [COX-2] in the highly malignant breast cancer cell line MDA-MB-231 below detectable levels in *response* to or 12-O-tetradecanoylphorbol-13-acetate treatment . Negative_regulation PTGS2 IL1B 20717505 2306737 AF pellet in NCCM significantly decreased the expression of iNOS and [COX-2] in *response* to 1ng/ml , stimulation at 24 hours ( p < 0.05 ) . Negative_regulation PTGS2 IL1B 9705828 526087 Inhibition of *induced* [COX-2] and elevated ICAM-1 expression , an effect reversed by exogenous PGE2 . Negative_regulation PTGS2 MAP2K6 11085935 750663 Similarly , activation of JNK by Ad-MKK7D and p38-MAPK by *resulted* in the increased expression of [PGHS-2] . Negative_regulation PTGS2 MAP2K6 12444157 1017391 [COX-2] expression was *prevented* by signal regulated kinase 1/2 and NF-kappaB inhibitors . Negative_regulation PTGS2 MAP2K6 12649265 1080048 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant or p38beta2 MAPK *inhibited* interleukin-1beta induced p38 MAPK activation , [COX-2] gene expression , and PGE2 release . Negative_regulation PTGS2 MAP2K6 14581482 1186932 Either PD98059 or U0126 , selective inhibitors of , or overexpression of a dominant negative MEK-1 inhibited interleukin-1beta- *induced* ERK activation and the expression of iNOS and [COX-2] but had essentially no effect on the expression of VCAM-1 and Mn-SOD . Negative_regulation PTGS2 MAP2K6 19139002 2005843 Here , we report that delphinidin , a major dietary anthocyanidin , *inhibits* tumor promoter induced transformation and [cyclooxygenase-2 (COX-2)] expression in JB6 promotion-sensitive mouse skin epidermal ( JB6 P+ ) cells by directly targeting Raf and ( MEK ) . Negative_regulation PTGS2 MMP28 16101137 1444179 Bis-EUG , and bis-MMP *inhibited* [COX-2] gene expression at concentrations of 300 microM , 500 microM and 500 microM , respectively . Negative_regulation PTGS2 MMP7 16101137 1444194 Bis-EUG , and bis-MMP *inhibited* [COX-2] gene expression at concentrations of 300 microM , 500 microM and 500 microM , respectively . Negative_regulation PTGS2 RARB 16170369 1489112 This study demonstrated that BPDE suppressed expression of ( 2 ) *results* in [COX-2] induction and restoration of RAR-beta ( 2 ) expression reduces COX-2 protein in esophageal cancer cells , thereby further supporting our previous finding that RAR-beta ( 2 ) plays an important role in suppressing esophageal carcinogenesis . Negative_regulation PTGS2 RCAN1 19926569 2190233 overexpression *attenuates* NFAT transcriptional activity and [COX2] protein expression , whereas knockdown of endogenous DSCR1 enhances NFAT transcriptional activity . Negative_regulation PTGS2 S1PR3 12796504 1120128 Transfection of S1P1 or but not of S1P2 antisense oligonucleotide *inhibited* S1P induced [COX-2] expression and PGE2 production in WISH cells , indicating the involvements of S1P1 and S1P3 in the processes . Negative_regulation PTGS2 SRGN 19123332 2004916 ( 40 mg x kg ( -1 ) d ( -1 ) ) could decrease the serum level of inflammatory factor TNF-alpha , and slightly *inhibit* [COX-2] and ICAM-1 protein expression in ischemic myocardium of AMI rats . Negative_regulation PTGS2 SRGN 23570999 2783230 Wattakaka volubilis steroidal glycoside mixture ( WVSM ) and ( 1-50 µM ) significantly *inhibited* the [COX-2] and iNOS enzymes resulting in low levels of PGE2 and NO in LPS induced RAW 264.7 macrophage cells . Negative_regulation PTGS2 TGM2 24009824 2714631 Role of in TPA ear edema is examined using Tgase-2 ( -/- ) mice and TPA did not *induce* [COX-2] expression in ear of Tgase-2 ( -/- ) mice . Negative_regulation PTGS2 TNF 10866999 722314 An activator of peroxisome proliferator activated receptor gamma , 15-deoxy-Delta ( 12,14 ) -prostaglandin J ( 2 ) , also induces [COX-2] expression and *inhibits* induced NFkappaB activation and COX-2 expression . Negative_regulation PTGS2 TNF 17384033 1715824 Pre-treatment with pyrolidine dithiocarbamate ( PDTC ) , one of the NF-kappaB inhibitors , prevented binding to the [COX-2] promoter and expression of COX-2 protein in *response* to . Negative_regulation PTGS2 TNF 18068105 1846996 The JAK3 inhibitor had no effect on [COX-2] expression , and production was slightly *inhibited* only at higher drug concentrations ( 30 microM ) . Negative_regulation PTGS2 TNF 19123332 2004915 PrG ( 40 mg x kg ( -1 ) d ( -1 ) ) could decrease the serum level of inflammatory factor , and slightly *inhibit* [COX-2] and ICAM-1 protein expression in ischemic myocardium of AMI rats . Negative_regulation PTGS2 TNF 21566012 2458889 also induced COX-2 protein and mRNA expression in YAMC cells , but blockade of EGFR kinase activity or expression *inhibited* [COX-2] upregulation . Negative_regulation PTGS2 TNF 22303922 2668276 SPEE treatment significantly inhibited the LPS induced production of NO , prostaglandin E ( 2 ) , interleukin-6 , and and *inhibited* the expression of iNOS and [COX-2] via attenuation of NF-?B p65 expression . Negative_regulation PTGS2 TNF 22418033 2582640 Danshensu partly blocked the expression of RAGE , p-p38 , and [COX-2] , and NF-?B activation , and *inhibited* the increase of , IL-6 , and PGE2 . Negative_regulation PTGS2 TNF 23646479 2779665 Polydatin improved the sepsis induced mortality dose-dependently , *inhibited* increased ALT , AST activity and , decreased the hepatic [COX-2] protein expression , and attenuated the pathological injury of the liver ( P < 0.05 ) . Negative_regulation PTGS2 TNF 23756390 2797849 increased the expression of COX-2 , iNOS and inflammatory cytokines , but GS-HCl significantly *attenuated* TNF-a induced [COX-2] expression . Negative_regulation PTH IL1B 21195929 2373936 [PTH] secretion is *suppressed* by and interleukin-6 , which are proinflammatory cytokines that are associated with poor outcome in dialysis patients . Negative_regulation PTH TCN1 23368947 2853730 significantly *reduced* [PTH] or PGE2 elevated expression of MMP-13 in osteoblastic cells without affecting basal levels of the mRNA . Negative_regulation PTH TCN1 23368947 2853734 A promoter assay indicated that directly *inhibits* the activation of the [PTH-responsive] minimal promoter of MMP-13 . Negative_regulation PTHLH IL1B 9525978 495945 TNF-alpha and stimulated PTHrP expression in synoviocytes , while dexamethasone and interferon-gamma , agents with some therapeutic efficacy in the treatment of RA , *inhibited* [PTHrP] release . Negative_regulation PTHLH TNF 9525978 495944 and IL-1beta stimulated PTHrP expression in synoviocytes , while dexamethasone and interferon-gamma , agents with some therapeutic efficacy in the treatment of RA , *inhibited* [PTHrP] release . Negative_regulation PTK2 ANGPT1 16842749 1591554 Our results show that *inhibited* activity of [PTK] to 60 % of basic activity . Negative_regulation PTK6 ANGPT1 16842749 1591555 Our results show that *inhibited* activity of [PTK] to 60 % of basic activity . Negative_regulation PTK7 ANGPT1 16842749 1591556 Our results show that *inhibited* activity of [PTK] to 60 % of basic activity . Negative_regulation PTPN11 EPHB2 12482708 1024516 Mutant ( but not wt ) [SHP-2] expression also *inhibited* NGF stimulated activation . Negative_regulation PTPN13 TNF 10497846 647534 We conclude that a spontaneous and rapid down-regulation of [Fap-1] , possibly *induced* by , a cytokine shown to be present in excess in MDS marrows , may underlie the increased apoptotic death of hematopoietic cells in these patients . Negative_regulation PTPN6 EPHB2 10406457 629408 Alanine substitutions further demonstrated that lysine 240 , asparagine 242 , and serine 243 are key residues for AT2 induced apoptosis , *inhibition* , and [SHP-1] activation . Negative_regulation PTPN6 EPHB2 20007589 2174983 The augmented activity *delayed* [SHP-1] recruitment to the TCR synapse and sustained TCR induced Zap70 and NF-kappaB signaling , facilitating responses to suboptimal stimulation . Negative_regulation PTPRC SELL 8693290 372836 [CD45] engagement *induces* down-regulation . Negative_regulation PTPRC SELL 8693290 372840 The MoAbs IOL1b , AICD45.2 and GAP8.3 recognized granulocyte expressed [CD45] but did not *induce* loss of expression of granulocytes . Negative_regulation PTPRC TNF 9867218 556491 Lymphoid hyperplasia , [CD45RBhigh] to CD45RBlow T-cell imbalance , and suppression of Type I diabetes mellitus *result* from blockade in NOD -- > NOD-scid adoptive T cell transfer . Negative_regulation PTTG1 CLU 23051594 2702842 FOXL2 binds and suppresses the PTTG promoter , and also *suppresses* [PTTG] expression , thus neutralizing protumorigenic PTTG gonadotroph tumor cell properties . Negative_regulation PTTG1IP IL1B 10210154 607485 Caerulein induced pancreatitis ( CIP ) led to 42 % decrease in DNA synthesis , 30 % *inhibition* of [PBF] , as well as , a significant increase in pancreatic weight , plasma amylase activity , plasma concentration , and development of the histological signs of pancreatic damage ( edema , leukocyte infiltration and vacuolization ) . Negative_regulation PTTG2 CLU 23051594 2702844 FOXL2 binds and suppresses the PTTG promoter , and also *suppresses* [PTTG] expression , thus neutralizing protumorigenic PTTG gonadotroph tumor cell properties . Negative_regulation PTX3 CAPN8 21723247 2461162 Here , we show that various inhibitors ( PD150606 , PD151746 , N-acetyl-Leu-Leu-Nle-CHO [ ALLN ] , N-acetyl-Leu-Leu-Met-CHO [ ALLM ] , and calpeptin ) and ?-secretase inhibitor I *induced* [PTx-sensitive] increase in cytoplasmic free Ca ( 2+ ) ( [ Ca ( 2+ ) ] ( i ) ) in human neutrophils and neutrophil migration . Negative_regulation PTX3 EPHB2 19742132 2135057 In addition , [pertussis toxin (PTX)] , a Gi protein inhibitor , *induced* an inhibitory effect on p38 MAPK , phosphorylation and RASMCs migration . Negative_regulation PTX3 SELL 24387024 903802 [PTX] *induced* the down-regulation of expression in dose- and time dependent manner . Negative_regulation PTX3 TNF 8132735 251624 These findings demonstrate that [PTX] has a marked suppression on IL-2 mediated activation of immature free NK cells and that the suppression is *due* , in large part , to PTX mediated inhibition of endogenous secretion . Negative_regulation PTX4 CAPN8 21723247 2461124 Here , we show that various inhibitors ( PD150606 , PD151746 , N-acetyl-Leu-Leu-Nle-CHO [ ALLN ] , N-acetyl-Leu-Leu-Met-CHO [ ALLM ] , and calpeptin ) and ?-secretase inhibitor I *induced* [PTx-sensitive] increase in cytoplasmic free Ca ( 2+ ) ( [ Ca ( 2+ ) ] ( i ) ) in human neutrophils and neutrophil migration . Negative_regulation PTX4 EPHB2 19742132 2135054 In addition , [pertussis toxin (PTX)] , a Gi protein inhibitor , *induced* an inhibitory effect on p38 MAPK , phosphorylation and RASMCs migration . Negative_regulation PTX4 SELL 24387024 903801 [PTX] *induced* the down-regulation of expression in dose- and time dependent manner . Negative_regulation PTX4 TNF 8132735 251623 These findings demonstrate that [PTX] has a marked suppression on IL-2 mediated activation of immature free NK cells and that the suppression is *due* , in large part , to PTX mediated inhibition of endogenous secretion . Negative_regulation PVR TNF 1741548 171741 *resulted* in increases in pulmonary arterial pressure ( Ppa ) and [pulmonary vascular resistance (PVR)] within 15 min , and the values were sustained for the 5-h experiment duration . Negative_regulation PXN CAPN8 12490576 1033259 The goal of the present study was to determine the *role* of in changes in plasma membrane permeability and cytoskeleton associated [paxillin] , vinculin , talin , and alpha-actinin levels during acute renal cell death . Negative_regulation PXN CAPN8 16723743 1565543 In the present work , we show that inhibition of in primary mouse dendritic cells *leads* to enhanced accumulation of actin filaments , the Wiskott Aldrich Syndrome protein (WASP) , beta ( 2 ) integrins , talin , [paxillin] and vinculin in podosomes . Negative_regulation PXN EPHB2 16339552 1491634 A role for phosphatidylinositol 3-kinase in TCR stimulated activation *leading* to [paxillin] phosphorylation and CTL degranulation . Negative_regulation QRICH1 FOXO1 22820375 2640253 Conditional activation of also *led* to an increased level of [glutamine] production . Negative_regulation QRICH2 FOXO1 22820375 2640257 Conditional activation of also *led* to an increased level of [glutamine] production . Negative_regulation RAB31 CALM3 10545100 564238 Disruption of interaction , but not other effector interactions , *prevents* [Rab3] inhibition of exocytosis . Negative_regulation RAB31 GDI1 11389151 822213 Membrane targeting of a Rab GTPase that fails to associate with [Rab escort protein (REP)] or guanine nucleotide dissociation *inhibitor* ( ) . Negative_regulation RAB31 GDI1 11786539 928848 However , no protein acting like Rho and [Rab] dissociation *inhibitor* ( ) that regulate the membrane association of Rho and Rab GTPases has been described for Ras and closely related proteins . Negative_regulation RAB31 GDI1 22272185 2545158 The persistence of the Q ( bc ) R cis-complex and the formation of the Q ( a ) -Q ( bc ) R trans-complex are both sensitive to the [Rab-GTPase] *inhibitor* , , and to mutations in the vacuolar tether complex , HOPS ( HOmotypic fusion and vacuolar Rabein Sorting complex ) . Negative_regulation RAB31 GDI1 8915007 395745 The cDNA encoding a [Ypt/Rab] guanosine dissociation *inhibitor* ( ) was isolated from the multicellular green alga Volvox carteri , representing the first complete plant gdi gene described . Negative_regulation RAB31 GDI2 11389151 822214 Membrane targeting of a Rab GTPase that fails to associate with [Rab escort protein (REP)] or guanine nucleotide dissociation *inhibitor* ( ) . Negative_regulation RAB31 GDI2 11786539 928849 However , no protein acting like Rho and [Rab] dissociation *inhibitor* ( ) that regulate the membrane association of Rho and Rab GTPases has been described for Ras and closely related proteins . Negative_regulation RAB31 GDI2 22272185 2545159 The persistence of the Q ( bc ) R cis-complex and the formation of the Q ( a ) -Q ( bc ) R trans-complex are both sensitive to the [Rab-GTPase] *inhibitor* , , and to mutations in the vacuolar tether complex , HOPS ( HOmotypic fusion and vacuolar Rabein Sorting complex ) . Negative_regulation RAB31 GDI2 8915007 395746 The cDNA encoding a [Ypt/Rab] guanosine dissociation *inhibitor* ( ) was isolated from the multicellular green alga Volvox carteri , representing the first complete plant gdi gene described . Negative_regulation RABEPK ARSA 9808189 545150 was found to *inhibit* secretion of the IL-12 heterodimer as well as [p40] monomer by human monocytic cells . Negative_regulation RABEPK EPHB2 20851927 2388989 Inhibition of p38 , but not , *attenuated* production of both [IL12/IL23p40] and TNF-a . Negative_regulation RABEPK TNF 21545584 2435327 treatment *induced* a decrease in TNF-a , [IL-12p40] and IL-10 mRNA levels in peritoneal cells following PPD stimulation while live M. tuberculosis caused an increase in TNF-a mRNA and a decrease in the IL-10 mRNA expression . Negative_regulation RAC1 CAPN8 12649322 1072365 Further , both inhibition and stimulation with IL-8 and formyl-Met-Leu-Phe ( fMLP ) *induced* an increase in Cdc42 and [Rac] activation . Negative_regulation RAC1 EPHB2 12777392 1119830 Initiation and transduction of stretch induced RhoA and [Rac1] *activation* through caveolae : cytoskeletal regulation of translocation . Negative_regulation RAC1 EPHB2 15351743 1292653 Expression of Gab1 PI3K-m in SK-N-MC human primitive neuroectodermal tumor cells expressing wild-type RET markedly impaired Akt phosphorylation , [Rac1] activation , and lamellipodia formation that were *induced* by GDNF whereas expression of Gab1 SHP2-m partially impaired activation . Negative_regulation RAC1 ITGB2 21206905 2359239 Engagement of to its ligand , ICAM-1 , in human peripheral T cells *resulted* in rapid activation of [Rac1] and Rac2 . Negative_regulation RAC1 MAP2K6 15496479 1359583 *prevented* accumulation of [Rac1] in the nucleus . Negative_regulation RAC1 MAP2K6 17854274 1810486 Last , deficiency *led* to an increase in [Rac1-GTP] levels in brain tissue . Negative_regulation RAC1 MAP2K6 20869211 2337203 Moreover , overexpression of ultimately *led* to the upregulation of Cdc42 and [Rac1] , suggesting that MKK6 acts as a crucial upstream signaling molecule for Rho family GTPases . Negative_regulation RAC1 NOSTRIN 22751148 2634458 NOSTRIN forms a complex with the GTPase Rac1 and its exchange factor Sos1 and overexpression of in cells *induces* [Rac1] activation . Negative_regulation RAC1 S1PR3 12588974 1059730 Upon inactivation of Gi by pertussis toxin , *mediated* inhibition of [Rac] and migration just like S1P2 . Negative_regulation RAC1 SPHK1 21304987 2388597 Silencing of by siRNA *attenuated* [Rac1] and IQGAP1 translocation to the cell periphery ; Negative_regulation RAC1 TNF 14576080 1199896 Expression of dominant negative [N17Rac1] by adenovirus suppressed *induced* MCP-1 mRNA levels and MCP-1 protein secretion . Negative_regulation RAC2 CAPN8 12649322 1072379 Further , both inhibition and stimulation with IL-8 and formyl-Met-Leu-Phe ( fMLP ) induced an *increase* in Cdc42 and [Rac] activation . Negative_regulation RAC2 ITGB2 21206905 2359240 Engagement of to its ligand , ICAM-1 , in human peripheral T cells *resulted* in rapid activation of Rac1 and [Rac2] . Negative_regulation RAC2 S1PR3 12588974 1059731 Upon inactivation of Gi by pertussis toxin , *mediated* inhibition of [Rac] and migration just like S1P2 . Negative_regulation RAC3 CAPN8 12649322 1072393 Further , both inhibition and stimulation with IL-8 and formyl-Met-Leu-Phe ( fMLP ) induced an *increase* in Cdc42 and [Rac] activation . Negative_regulation RAC3 S1PR3 12588974 1059732 Upon inactivation of Gi by pertussis toxin , *mediated* inhibition of [Rac] and migration just like S1P2 . Negative_regulation RAD50 DGKI 15894621 1411631 regulates Ras guanyl releasing protein 3 and *inhibits* [Rap1] signaling . Negative_regulation RAD50 DGKI 15894621 1411656 We demonstrate that bound to RasGRP3 and *inhibited* its activation of [Rap1] by metabolizing DAG . Negative_regulation RAD50 F2R 15078882 1251912 Concomitant stimulation of both and PAR-4 in the presence of ADP scavengers still *resulted* in a strongly reduced activation of [Rap1B] . Negative_regulation RAD50 MAP2K6 17646383 1793410 The downregulation of [Rap1GAP] by Ras *required* the activation of the signal regulated kinase cascade and was correlated with the induction of mesenchymal morphology and migratory behavior . Negative_regulation RAF1 EPHB2 10026138 591244 Upstream of , Shc was shown to be activated , but its downstream [Raf1] and ERK were *inhibited* . Negative_regulation RAF1 EPHB2 17707940 1800749 Endothelin induced phosphorylation was independent of integrin ligands , and an inhibitor of G ( q/11 ) , YM-254890 , as well as pertussis toxin , partially *inhibited* endothelin stimulated phosphorylation of [Raf-1] and ERK . Negative_regulation RAF1 EPHB2 18332218 1881424 In B-Raf-deficient cells , more [Raf-1] is recruited to MEK , yet phosphorylation is *impaired* . Negative_regulation RAF1 EPHB2 22206679 2537593 Here , we showed that although UI-152 inhibited , it *induced* B-Raf binding to Raf-1 as well as [Raf-1] activation . Negative_regulation RAF1 EPHB2 24405594 2900539 Western blotting was conducted to find out whether RAD001 induced feedback activation and to identify whether RAD001 in combination with c-Raf inhibitor sorafenib could effectively *block* the feedback activation of [c-Raf] and downstream proteins . Negative_regulation RAF1 MAP2K6 10066754 593715 Furthermore , agents that elevated cAMP suppressed IL-3 induced [c-Raf] activation but did not *inhibit* activation . Negative_regulation RAF1 MAP2K6 12063170 953303 The , U0126 , that specifically inhibits the activation of ERK also *blocked* the phosphorylation of p66shc and [Raf-1] , suggesting that these processes were MEK dependent , quite different from that which was observed in A549 cells . Negative_regulation RAF1 MAP2K6 16086581 1443174 Second , we have injected JNK , [c-raf] , and MEK into oocytes alone and in the *presence* of raf and inhibitors and found that JNK activation is independent of the raf-MEK-MAPK pathway but that activated JNK activates raf , allowing for activation of ERK . Negative_regulation RAF1 MAP2K6 16301744 1485274 BAFF induced delayed but sustained stimulation of extracellular signal regulated kinase ( ERK ) and its activators , mitogen activated protein kinase/ERK activating kinase ( MEK ) and [c-Raf] , and inhibitors *promoted* accumulation and dephosphorylation of Bim . Negative_regulation RAF1 MAP2K6 16916643 1602522 [Raf-1] depletion or *inhibition* reverses the reduction in the mitotic index , whereas hyperactivation of Raf mimics the RKIP-depletion phenotype . Negative_regulation RAF1 MAP2K6 18332218 1881430 In B-Raf-deficient cells , more [Raf-1] is recruited to MEK , yet phosphorylation is *impaired* . Negative_regulation RAG1 FOXO1 18469817 1916592 directly activated transcription of the Rag1-Rag2 locus throughout early B cell development , and a decrease in Foxo1 protein *diminished* the induction of [Rag1] and Rag2 transcription in a model of receptor editing . Negative_regulation RAG1 ZFP57 23076336 2729007 *represses* [Rag1] and Rag2 expression indirectly by repressing the expression of Zfp609 . Negative_regulation RAG2 FOXO1 18469817 1916593 directly activated transcription of the Rag1-Rag2 locus throughout early B cell development , and a decrease in Foxo1 protein *diminished* the induction of Rag1 and [Rag2] transcription in a model of receptor editing . Negative_regulation RAG2 ZFP57 23076336 2729025 *represses* Rag1 and [Rag2] expression indirectly by repressing the expression of Zfp609 . Negative_regulation RAI1 TGM2 11350930 814737 *Role* of in [retinoic acid induced] activation of RhoA associated kinase-2 . Negative_regulation RAI14 TGM2 11350930 814736 *Role* of in [retinoic acid induced] activation of RhoA associated kinase-2 . Negative_regulation RAI2 TGM2 11350930 814738 *Role* of in [retinoic acid induced] activation of RhoA associated kinase-2 . Negative_regulation RAMP1 TNF 15245870 1270945 *induced* time- and dose dependent decreases in the expression of CRLR and [RAMP1/2] mRNAs , thereby diminishing AM-evoked cAMP production . Negative_regulation RANBP2 IFI27 12490316 1033145 To clarify the *roles* of and c-myc in [nasopharyngeal carcinoma (NPC)] , we used immunohistochemical studies to examine the expression of p27 and c-myc proteins in 69 patients with NPC . Negative_regulation RANBP2 TNF 22025632 2508092 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation RANGAP1 TNF 22025632 2508093 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation RAP1A ITGB2 11165259 782763 Specific phosphatidylinositol-3-kinase (PI3K) inhibitors suppressed both LFA-1 activation and [Rap1GTP] generation , and abrogation of Rap1GTP by retroviral over-expression of a specific Rap1 GTPase activating protein , SPA-1 , totally *inhibited* the mediated cell adhesion . Negative_regulation RARA IL1B 12105223 976674 *mediated* suppression of [RXR:RAR] transactivation of the Ntcp promoter is JNK dependent . Negative_regulation RARA IL1B 12105223 976678 Curcumin , but not PD98059 or SB203580 , inhibited *mediated* suppression of nuclear [RXR:RAR] binding activity , which correlated with inhibition of JNK phosphorylation and phospho-JNK mediated phosphorylation of RXR . Negative_regulation RARA MAP2K6 18445086 1921150 inhibition *induces* caspases activation , differentiation blockade and [PML/RARalpha] degradation in acute promyelocytic leukaemia . Negative_regulation RARB ADCY1 1323569 192436 Forskolin , an activator , and the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine ( IBMX ) decreased constitutive RAR-beta mRNA levels but did not *block* induction of [RAR-beta] by retinoic acid . Negative_regulation RARB ADCY10 1323569 192435 Forskolin , an activator , and the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine ( IBMX ) decreased constitutive RAR-beta mRNA levels but did not *block* induction of [RAR-beta] by retinoic acid . Negative_regulation RARB ADCY2 1323569 192437 Forskolin , an activator , and the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine ( IBMX ) decreased constitutive RAR-beta mRNA levels but did not *block* induction of [RAR-beta] by retinoic acid . Negative_regulation RARB ADCY3 1323569 192438 Forskolin , an activator , and the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine ( IBMX ) decreased constitutive RAR-beta mRNA levels but did not *block* induction of [RAR-beta] by retinoic acid . Negative_regulation RARB ADCY4 1323569 192439 Forskolin , an activator , and the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine ( IBMX ) decreased constitutive RAR-beta mRNA levels but did not *block* induction of [RAR-beta] by retinoic acid . Negative_regulation RARB ADCY5 1323569 192440 Forskolin , an activator , and the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine ( IBMX ) decreased constitutive RAR-beta mRNA levels but did not *block* induction of [RAR-beta] by retinoic acid . Negative_regulation RARB ADCY6 1323569 192441 Forskolin , an activator , and the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine ( IBMX ) decreased constitutive RAR-beta mRNA levels but did not *block* induction of [RAR-beta] by retinoic acid . Negative_regulation RARB ADCY7 1323569 192442 Forskolin , an activator , and the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine ( IBMX ) decreased constitutive RAR-beta mRNA levels but did not *block* induction of [RAR-beta] by retinoic acid . Negative_regulation RARB ADCY8 1323569 192443 Forskolin , an activator , and the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine ( IBMX ) decreased constitutive RAR-beta mRNA levels but did not *block* induction of [RAR-beta] by retinoic acid . Negative_regulation RARB ADCY9 1323569 192444 Forskolin , an activator , and the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine ( IBMX ) decreased constitutive RAR-beta mRNA levels but did not *block* induction of [RAR-beta] by retinoic acid . Negative_regulation RARB CTNNB1 15856452 1439641 HLD consumption *induced* early downregulation of PPARgamma ( -33.1 % ) and [RARbeta] ( -53.1 % ) mRNA expression concomitant with an increase in levels of COX-2 ( +45.5 % ) and ( +84.56 % ) and in the number of ACF ( 191.56 +/- 88.60 vs. 21.14 +/- 11.64 , p < 0.05 ) . Negative_regulation RARB DES 12223147 987673 Transfection of RAR-beta gene and treatment with ligand ATRA could increase the expression of [RAR-beta] protein for at least 144h and *inhibit* the proliferation and the expression of alpha-SMA and in PDGF activated HSC . Negative_regulation RARB EGF 15766561 1383687 An receptor inhibitor *induces* [RAR-beta] expression in breast and ovarian cancer cells . Negative_regulation RARB EGFR 17286282 1718476 The inhibitor PD153035 cooperates with retinoic acid during growth inhibition and *induces* [retinoic acid receptor-beta] suggesting that ErbB-1 controls retinoic acid receptor-beta . Negative_regulation RARB ESR1 12943740 1133788 Using RT-PCR and RNAse protection assays , we observed that expression of *suppresses* basal expression of the RA-responsive gene [RARbeta2] , while allowing it to be strongly induced by tRA . Negative_regulation RARB HACE1 19350571 2081062 On the other hand , *inhibits* the RA dependent degradation of [RARbeta] ( 3 ) . Negative_regulation RARB HDAC1 12392082 1007631 Treatment with the histone deacetvlase inhibitor trichostatin A (TSA) increased both basal and RA-induced betaRARE activity in DLD-1 , indicating that is *involved* in the regulation of [RARbeta] gene expression . Negative_regulation RARB HDAC1 15651062 1402317 In vivo imaging of [retinoic acid receptor beta2] transcriptional *activation* by the inhibitor MS-275 in retinoid-resistant prostate cancer cells . Negative_regulation RARB HDAC1 15867260 1402085 Therefore , we tested whether combining inhibitors with retinoic acid ( RA ) would *restore* [RARbeta2] receptor expression , leading to increased growth inhibition in RCC cells . Negative_regulation RARB HDAC10 12392082 1007629 Treatment with the histone deacetvlase inhibitor trichostatin A (TSA) increased both basal and RA-induced betaRARE activity in DLD-1 , indicating that is *involved* in the regulation of [RARbeta] gene expression . Negative_regulation RARB HDAC10 15651062 1402315 In vivo imaging of [retinoic acid receptor beta2] transcriptional *activation* by the inhibitor MS-275 in retinoid-resistant prostate cancer cells . Negative_regulation RARB HDAC10 15867260 1402083 Therefore , we tested whether combining inhibitors with retinoic acid ( RA ) would *restore* [RARbeta2] receptor expression , leading to increased growth inhibition in RCC cells . Negative_regulation RARB HDAC11 12392082 1007630 Treatment with the histone deacetvlase inhibitor trichostatin A (TSA) increased both basal and RA-induced betaRARE activity in DLD-1 , indicating that is *involved* in the regulation of [RARbeta] gene expression . Negative_regulation RARB HDAC11 15651062 1402316 In vivo imaging of [retinoic acid receptor beta2] transcriptional *activation* by the inhibitor MS-275 in retinoid-resistant prostate cancer cells . Negative_regulation RARB HDAC11 15867260 1402084 Therefore , we tested whether combining inhibitors with retinoic acid ( RA ) would *restore* [RARbeta2] receptor expression , leading to increased growth inhibition in RCC cells . Negative_regulation RARB HDAC2 12392082 1007632 Treatment with the histone deacetvlase inhibitor trichostatin A (TSA) increased both basal and RA-induced betaRARE activity in DLD-1 , indicating that is *involved* in the regulation of [RARbeta] gene expression . Negative_regulation RARB HDAC2 15651062 1402318 In vivo imaging of [retinoic acid receptor beta2] transcriptional *activation* by the inhibitor MS-275 in retinoid-resistant prostate cancer cells . Negative_regulation RARB HDAC2 15867260 1402086 Therefore , we tested whether combining inhibitors with retinoic acid ( RA ) would *restore* [RARbeta2] receptor expression , leading to increased growth inhibition in RCC cells . Negative_regulation RARB HDAC3 12392082 1007633 Treatment with the histone deacetvlase inhibitor trichostatin A (TSA) increased both basal and RA-induced betaRARE activity in DLD-1 , indicating that is *involved* in the regulation of [RARbeta] gene expression . Negative_regulation RARB HDAC3 15651062 1402319 In vivo imaging of [retinoic acid receptor beta2] transcriptional *activation* by the inhibitor MS-275 in retinoid-resistant prostate cancer cells . Negative_regulation RARB HDAC3 15867260 1402087 Therefore , we tested whether combining inhibitors with retinoic acid ( RA ) would *restore* [RARbeta2] receptor expression , leading to increased growth inhibition in RCC cells . Negative_regulation RARB HDAC4 12392082 1007624 Treatment with the histone deacetvlase inhibitor trichostatin A (TSA) increased both basal and RA-induced betaRARE activity in DLD-1 , indicating that is *involved* in the regulation of [RARbeta] gene expression . Negative_regulation RARB HDAC4 15651062 1402310 In vivo imaging of [retinoic acid receptor beta2] transcriptional *activation* by the inhibitor MS-275 in retinoid-resistant prostate cancer cells . Negative_regulation RARB HDAC4 15867260 1402078 Therefore , we tested whether combining inhibitors with retinoic acid ( RA ) would *restore* [RARbeta2] receptor expression , leading to increased growth inhibition in RCC cells . Negative_regulation RARB HDAC5 12392082 1007628 Treatment with the histone deacetvlase inhibitor trichostatin A (TSA) increased both basal and RA-induced betaRARE activity in DLD-1 , indicating that is *involved* in the regulation of [RARbeta] gene expression . Negative_regulation RARB HDAC5 15651062 1402314 In vivo imaging of [retinoic acid receptor beta2] transcriptional *activation* by the inhibitor MS-275 in retinoid-resistant prostate cancer cells . Negative_regulation RARB HDAC5 15867260 1402082 Therefore , we tested whether combining inhibitors with retinoic acid ( RA ) would *restore* [RARbeta2] receptor expression , leading to increased growth inhibition in RCC cells . Negative_regulation RARB HDAC6 12392082 1007625 Treatment with the histone deacetvlase inhibitor trichostatin A (TSA) increased both basal and RA-induced betaRARE activity in DLD-1 , indicating that is *involved* in the regulation of [RARbeta] gene expression . Negative_regulation RARB HDAC6 15651062 1402311 In vivo imaging of [retinoic acid receptor beta2] transcriptional *activation* by the inhibitor MS-275 in retinoid-resistant prostate cancer cells . Negative_regulation RARB HDAC6 15867260 1402079 Therefore , we tested whether combining inhibitors with retinoic acid ( RA ) would *restore* [RARbeta2] receptor expression , leading to increased growth inhibition in RCC cells . Negative_regulation RARB HDAC7 12392082 1007627 Treatment with the histone deacetvlase inhibitor trichostatin A (TSA) increased both basal and RA-induced betaRARE activity in DLD-1 , indicating that is *involved* in the regulation of [RARbeta] gene expression . Negative_regulation RARB HDAC7 15651062 1402313 In vivo imaging of [retinoic acid receptor beta2] transcriptional *activation* by the inhibitor MS-275 in retinoid-resistant prostate cancer cells . Negative_regulation RARB HDAC7 15867260 1402081 Therefore , we tested whether combining inhibitors with retinoic acid ( RA ) would *restore* [RARbeta2] receptor expression , leading to increased growth inhibition in RCC cells . Negative_regulation RARB HDAC8 12392082 1007623 Treatment with the histone deacetvlase inhibitor trichostatin A (TSA) increased both basal and RA-induced betaRARE activity in DLD-1 , indicating that is *involved* in the regulation of [RARbeta] gene expression . Negative_regulation RARB HDAC8 15651062 1402309 In vivo imaging of [retinoic acid receptor beta2] transcriptional *activation* by the inhibitor MS-275 in retinoid-resistant prostate cancer cells . Negative_regulation RARB HDAC8 15867260 1402077 Therefore , we tested whether combining inhibitors with retinoic acid ( RA ) would *restore* [RARbeta2] receptor expression , leading to increased growth inhibition in RCC cells . Negative_regulation RARB HDAC9 12392082 1007626 Treatment with the histone deacetvlase inhibitor trichostatin A (TSA) increased both basal and RA-induced betaRARE activity in DLD-1 , indicating that is *involved* in the regulation of [RARbeta] gene expression . Negative_regulation RARB HDAC9 15651062 1402312 In vivo imaging of [retinoic acid receptor beta2] transcriptional *activation* by the inhibitor MS-275 in retinoid-resistant prostate cancer cells . Negative_regulation RARB HDAC9 15867260 1402080 Therefore , we tested whether combining inhibitors with retinoic acid ( RA ) would *restore* [RARbeta2] receptor expression , leading to increased growth inhibition in RCC cells . Negative_regulation RARB MYC 19623543 2137545 Forced overexpression *inhibited* the [RARbeta] and PDLIM4 expression . Negative_regulation RARB PTGS2 15856452 1439642 HLD consumption *induced* early downregulation of PPARgamma ( -33.1 % ) and [RARbeta] ( -53.1 % ) mRNA expression concomitant with an increase in levels of ( +45.5 % ) and beta-catenin ( +84.56 % ) and in the number of ACF ( 191.56 +/- 88.60 vs. 21.14 +/- 11.64 , p < 0.05 ) . Negative_regulation RARB RARA 9116296 423563 Downregulation of in mice by antisense transgene *leads* to a compensatory increase in [RAR beta] and RAR gamma and development of lymphoma . Negative_regulation RARB RARG 1649387 162771 In the present report , we show that 1 , one of the two predominant RAR gamma isoforms , can *inhibit* the activity of RAR gamma 2 , [RAR beta] , and endogenous RAR on the beta RARE . Negative_regulation RARB RARS 15189119 1256676 We then focus on a discussion of RARalpha and acute promyelocytic leukemia followed by a discussion of the *role* of , in particular [RARbeta] expression , in other cancer types . Negative_regulation RARB RARS 9426695 481644 Together , our results show that expression of RAR beta plays a role in mediating retinoid response in lung cancer cells and that activation of or RXRs *contributes* to induction of [RAR beta] , growth inhibition and apoptosis by retinoids . Negative_regulation RARB SLC1A1 19450544 2120302 The ATRA dependent overexpression of the glutamate transporter *requires* [RARbeta] induction . Negative_regulation RARB SMN1 12223147 987672 Transfection of RAR-beta gene and treatment with ligand ATRA could increase the expression of [RAR-beta] protein for at least 144h and *inhibit* the proliferation and the expression of and desmin in PDGF activated HSC . Negative_regulation RARB TGFB1 11669453 872337 TGF-beta1 and forskolin , an activator of the cAMP pathway , inhibited RA-induced expression of RAR-beta mRNA in MEPM cells , though only *inhibited* RA-induced [RAR-beta] protein expression . Negative_regulation RARB TRIM26 19501957 2149464 may *inhibit* translocation of [RAR-beta] into the nucleus via competitive binding to RAR-beta with ATRA , which was reversed by AFP-siRNA transfection . Negative_regulation RARB VDR 10224118 610000 In addition , *mediates* a ligand dependent repression of the response of the [retinoic acid receptor beta2] promoter to retinoic acid , and the helix 3 and helix 12 mutants were unable to mediate transrepression . Negative_regulation RARG RARB 10523855 653752 This report finds [RARgamma] repression is *due* to selective repression of RARgamma but not transcription in NT2/D1-R1 cells . Negative_regulation RARRES1 LXN 23588494 2772994 Expression of both [RARRES1] and LXN was co-ordinately repressed by DNA methylation in prostate cancer cell lines and inhibition of RARRES1 and *increased* the invasive capacity of primary prostate cultures , which also fully rescued an inhibitory effect induced by atRA . Negative_regulation RASA1 FAS 11821389 922576 In the *presence* of NAD and , the [GAP] activity of full-length ExoS was reduced about 10-fold , whereas NAD and FAS did not affect the activity of the ExoS-GAP fragment . Negative_regulation RASA1 MAP2K6 17646383 1793417 The downregulation of [Rap1GAP] by Ras *required* the activation of the signal regulated kinase cascade and was correlated with the induction of mesenchymal morphology and migratory behavior . Negative_regulation RASA1 SELL 8693290 372841 The MoAbs IOL1b , AICD45.2 and [GAP8.3] recognized granulocyte expressed CD45 but did not *induce* loss of expression of granulocytes . Negative_regulation RB1 CCND1 10806303 692120 EGCG induced p21 ( CIP1/WAF1/SDI1 ) , *inhibited* pRB kinase activity , and impaired [pRB] phosphorylation . Negative_regulation RB1 CCND1 11514621 849433 However , [pRB] is hypophosphorylated in GFP-TAM67 arrested cells and the activity of both the : cdk and the cyclin E : cdk complexes are *impaired* . Negative_regulation RB1 CCND1 14693709 1194899 pRb is present in rat and human islets , and overexpression of *led* to strikingly enhanced [pRb] phosphorylation in both species . Negative_regulation RB1 CCND1 8552398 347207 In transformed cell lines , loss of [pRb] activity strongly correlates with a decrease in cyclin D1 protein expression , and conversely , introduction of pRb can *induce* promoter activity . Negative_regulation RB1 IFI27 18544045 2059227 Silencing the PTEN gene by siRNA transfection of IMA SMCs significantly induced the expression of [pRb] and *inhibited* expression , while , the expression levels of cyclin E , pRb , p21 and p27 were unaffected by the silencing of PTEN in SV SMCs . Negative_regulation RBBP4 CLU 20307625 2244624 We have observed earlier that [histone deacetylase (HDAC)] inhibitors can *induce* the expression of in several neuroblastoma and glioma cell lines . Negative_regulation RBBP4 MMP28 20144149 2236022 The present study demonstrates that expression is *induced* by [HDAC] ( histone deacetylase ) inhibitors and that this effect is mediated through the GT-box . Negative_regulation RBBP4 TNF 7691816 230984 In addition the cytokines interleukin-1 , -6 , and *mediate* a decrease in hepatic [SAP] ( FP ) transcript levels in female hamsters but did not cause a significant elevation of SAP ( FP ) mRNA in livers of male hamsters . Negative_regulation RBBP4 TNFSF10 18701496 1950473 Here , we show that the [histone deacetylase (HDAC)] inhibitors *induce* in human breast cancer cells . Negative_regulation RBBP7 CLU 20307625 2244625 We have observed earlier that [histone deacetylase (HDAC)] inhibitors can *induce* the expression of in several neuroblastoma and glioma cell lines . Negative_regulation RBBP7 MMP28 20144149 2236023 The present study demonstrates that expression is *induced* by [HDAC] ( histone deacetylase ) inhibitors and that this effect is mediated through the GT-box . Negative_regulation RBBP7 TNF 7691816 230985 In addition the cytokines interleukin-1 , -6 , and *mediate* a decrease in hepatic [SAP] ( FP ) transcript levels in female hamsters but did not cause a significant elevation of SAP ( FP ) mRNA in livers of male hamsters . Negative_regulation RBBP7 TNFSF10 18701496 1950474 Here , we show that the [histone deacetylase (HDAC)] inhibitors *induce* in human breast cancer cells . Negative_regulation RBFOX3 FOXO1 23742826 2823795 ATP *induced* the phosphorylation of [FoxO1/3a] at threonine 24/32 , whereas reduced the expression of . Negative_regulation RBL2 EPHB2 12456636 1021303 FRNK expression disrupted the formation of a v-Src-FAK signaling complex , *inhibited* [p130Cas] tyrosine phosphorylation , and attenuated v-Src stimulated and JNK kinase activation . Negative_regulation RBP4 TNF 19537932 2258074 We observed that while [RBP4] expression was strongly *inhibited* by and LPS , it was not affected by IL-6 . Negative_regulation RCAN1 CEBPB 20371871 2261758 Overexpression of *increased* activity of both the endogenous mouse [Rcan1-4] gene and a human RCAN1-4 luciferase reporter . Negative_regulation RCAN1 GCA 15939815 1420830 In neonatal cultured cardiac myocytes , inhibition of by HS142-1 ( 100 microg/mL ) *increased* basal and phenylephrine ( 10 ( -6 ) mol/L ) -stimulated calcineurin activity , nuclear translocation of NFATc3 , and [MCIP1] mRNA expression . Negative_regulation RCAN1 MAP3K7 19136967 2032072 Overexpression of TAK1 and TAB1 , or active ( DeltaN ) , *promoted* direct phosphorylation of [RCAN1] in vitro and in vivo . Negative_regulation RCAN1 MAP3K7 19136967 2032087 These results describe a signalling relationship between two central regulatory pathways in which TAK1-TAB1-TAB2 selectively *induces* calcineurin-NFAT signalling through direct phosphorylation of [RCAN1] , while calcineurin activation diminishes signalling by dephosphorylation of TAK1 and TAB1 . Negative_regulation RCAN1 PPP3CA 18294449 1878649 Ectopic [RCAN1] expression also *inhibited* signaling in the HUVEC cells . Negative_regulation RCAN1 PPP3CA 18319259 1904288 The ability of ATF6 to induce RCAN1 in vivo was replicated in cultured cardiac myocytes , where adenoviral ( AdV ) -mediated overexpression of activated ATF6 induced the [RCAN1] promoter , up-regulated RCAN1 mRNA , *inhibited* phosphatase activity , and exerted a striking growth modulating effect that was inhibited by RCAN1 targeted small interfering RNA . Negative_regulation RCAN1 PPP3CA 19136967 2032088 These results describe a signalling relationship between two central regulatory pathways in which TAK1-TAB1-TAB2 selectively *induces* calcineurin-NFAT signalling through direct phosphorylation of [RCAN1] , while activation diminishes TAK1 signalling by dephosphorylation of TAK1 and TAB1 . Negative_regulation RCAN1 PPP3CB 18294449 1878650 Ectopic [RCAN1] expression also *inhibited* signaling in the HUVEC cells . Negative_regulation RCAN1 PPP3CB 18319259 1904289 The ability of ATF6 to induce RCAN1 in vivo was replicated in cultured cardiac myocytes , where adenoviral ( AdV ) -mediated overexpression of activated ATF6 induced the [RCAN1] promoter , up-regulated RCAN1 mRNA , *inhibited* phosphatase activity , and exerted a striking growth modulating effect that was inhibited by RCAN1 targeted small interfering RNA . Negative_regulation RCAN1 PPP3CC 18294449 1878651 Ectopic [RCAN1] expression also *inhibited* signaling in the HUVEC cells . Negative_regulation RCAN1 PPP3CC 18319259 1904290 The ability of ATF6 to induce RCAN1 in vivo was replicated in cultured cardiac myocytes , where adenoviral ( AdV ) -mediated overexpression of activated ATF6 induced the [RCAN1] promoter , up-regulated RCAN1 mRNA , *inhibited* phosphatase activity , and exerted a striking growth modulating effect that was inhibited by RCAN1 targeted small interfering RNA . Negative_regulation RCAN1 PPP3R1 19136967 2032089 These results describe a signalling relationship between two central regulatory pathways in which TAK1-TAB1-TAB2 selectively *induces* calcineurin-NFAT signalling through direct phosphorylation of [RCAN1] , while activation diminishes TAK1 signalling by dephosphorylation of TAK1 and TAB1 . Negative_regulation RCAN1 TAB1 19136967 2032071 Overexpression of and TAB1 , or active TAK1 ( DeltaN ) , *promoted* direct phosphorylation of [RCAN1] in vitro and in vivo . Negative_regulation RCAN1 TEF 21169383 2407772 Overexpression of is *sufficient* to induce [DSCR1-1L] expression . Negative_regulation RCAN1 TNF 16627481 1583040 We recently reported that thrombin and vascular endothelial growth factor , but not , *results* in dramatic up-regulation of [Down syndrome critical region (DSCR)-1] gene in endothelial cells , a negative feedback regulator of calcineurin-NFAT signaling . Negative_regulation RCAN1 VEGFA 16627481 1583041 We recently reported that thrombin and , but not tumor necrosis factor-alpha , *results* in dramatic up-regulation of [Down syndrome critical region (DSCR)-1] gene in endothelial cells , a negative feedback regulator of calcineurin-NFAT signaling . Negative_regulation RCAN1 VEGFA 20625401 2291753 We show that is able to induce RCAN1 .4 expression during cellular proliferation and differentiation , and that VEGF mediated expression of [RCAN1] .4 was *inhibited* by the use of inhibitors to protein kinase C ( PKC ) and calcineurin . Negative_regulation RCC2 TNF 22025632 2508080 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation REL ARSA 10602313 574669 4. In contrast , <5ASA> and sulfapyridine neither *inhibit* [NF-kappaB/Rel] activation nor induce apoptosis in T-lymphocytes at doses up to 5.0 mM . Negative_regulation RELA ANGPT1 17085463 1685085 *mediated* inhibition of increased [NF-kappaB-DNA] binding in nuclear extracts from HUVECs grown in high glucose was significantly blocked by soluble Tie2 receptor-Fc . Negative_regulation RELA ANGPT1 20060382 2205437 We further investigated the mechanism and found that could *block* LPS induced activation of [NF-kappaB] which has been shown to be necessary for macrophage activation with LPS treatment . Negative_regulation RELA ARSA 10602313 574670 4. In contrast , <5ASA> and sulfapyridine neither *inhibit* [NF-kappaB/Rel] activation nor induce apoptosis in T-lymphocytes at doses up to 5.0 mM . Negative_regulation RELA ARSA 10602313 574672 5. These results demonstrate that sulfasalazine , but not <5ASA> or sulfapyridine , strongly *inhibits* [NF-kappaB] activation and potently induces apoptosis in T-lymphocytes . Negative_regulation RELA ARSA 11133489 769142 *inhibited* TNF-alpha induced activation of [NF-kappa B] by preventing phosphorylation and subsequent degradation of I kappa B-alpha in a prostanoid independent manner . Negative_regulation RELA ARSA 11775855 581321 Both DEX and could *inhibit* the activation of [NF-kappa B] and reduce the release of TNF-alpha . Negative_regulation RELA ARSA 15085062 1234484 LDL induced activation of the transcription factor [NF-kappaB] was *inhibited* by , and ferritin protein was increased when endothelial cells were incubated with this drug . Negative_regulation RELA ARSA 15763541 1383553 Concomitantly , *inhibited* [nuclear factor (NF)-kappaB] activity , as well as the phosphorylation and breakdown of the inhibitory protein IkappaB-alpha . Negative_regulation RELA ARSA 15909110 1409485 SFZ , but not <5-ASA> or SPY , *inhibits* activation of [NF-kB] . Negative_regulation RELA ARSA 16199534 1483159 Biochemical analysis revealed that *inhibited* [NF-kappaB] activity , which is known to regulate BCL-2 gene expression , by dephosphorylating IkappaB-alpha and inhibiting IKKbeta activity but not by affecting the HER-2/neu phosphatidylinositol 3-kinase-Akt signal pathway . Negative_regulation RELA ARSA 17644113 1865903 Although , itself had no effect on the NF-kappaB pathway , nor did it *reduce* DC-induced [NF-kappaB] translocation , it did prevent DC-induced caspase-3 , -6 and -9 activation , poly ( ADP-ribose ) polymerase and lamin A processing , DNA degradation , and PKC signaling , all indices of apoptosis . Negative_regulation RELA ARSA 9808189 545154 Analysis of the regulation of the p40 gene promoter revealed that *inhibited* [NF-kappaB] activation and binding to the p40-kappaB site in the p40 promoter , leading to transcriptional repression of the p40 gene . Negative_regulation RELA BPI 17239348 1690526 Although the functional mechanism whereby extra-cellular BPI modulates the intra-cellular signal pathways selected by the TLR adaptors , MyD88 and TICAM-1 ( TRIF ) , remains unknown , we infer that the lipid A portion of LPS participates in LBP amplified IFN-beta induction and that binding to LPS *leads* to inhibition of the activation of [NF-kappaB] and IFN-beta by LPS or agonistic lipid A via TLR4 in an extrinsic mode . Negative_regulation RELA CAPN8 17323976 1711866 It reduces mitochondrial membrane potential by activating and *inhibits* [NF-kappaB] activity by increasing the ROS level . Negative_regulation RELA CCND1 17308107 1699453 Furthermore , chemical inhibition of the dependent kinase 4 (CDK4) kinase complex , used as a surrogate for cyclin D1 degradation , *caused* nucleolar translocation of [RelA] , repression of kappaB-driven transcription , and apoptosis , thereby reproducing the effects of aspirin . Negative_regulation RELA CCND1 19471891 2085396 [NF-kappaB] target gene expression of apoptotic cell death proteins ( Bax , caspase-3 , caspase-9 ) was significantly enhanced , but the expression of anti-apoptotic genes and cell proliferation marker genes ( Bcl-2 , inhibitor of apoptosis protein ( IAP-1 ) and X chromosome IAP (XIAP) , Cox-2 , c-Fos , c-Jun and ) was significantly *inhibited* by the combined treatment compared to Rg3 or docetaxel alone . Negative_regulation RELA CCND1 20596608 2286039 Pre-treatment of NS3 protein expressing cells with ERK inhibitor , PD98059 , blocked the activation of AP-1 and [NF-kappaB] , and *inhibited* expression and cell proliferation . Negative_regulation RELA CD14 11380692 820521 An approximately 70 % decrease of lipopeptide induced [NFkappaB] translocation and an about 50 % reduction of nitric oxide ( NO ) release was observed in the *presence* of . Negative_regulation RELA CD14 15618154 1357613 Here , we report that human high-dose LBP ( hd-LBP ) suppresses binding of both R-type and S-type LPS to and *inhibits* LPS induced nuclear translocation of [NF-kappaB] , although cellular uptake of R-type LPS was found to be increased by hd-LBP . Negative_regulation RELA CD14 16879219 1593848 Antirat and antirat TLR-4 antibodies *inhibited* LPS induced [NFkappaB] activation , and a NFkappaB inhibitor suppressed LPS induced decreased PS expression in both cells . Negative_regulation RELA CLU 12882985 1142758 Ectopic expression strongly *inhibited* [NF-kappaB] activity in human neuroblastoma cells and murine embryonic fibroblasts by stabilizing inhibitors of NF-kappaB ( IkappaBs ) . Negative_regulation RELA CLU 17359935 1712671 Presence of *reduced* [NF-kappaB] activation and expression of the NF-kappaB target genes TNF-alpha and MOB-1 under cell stress . Negative_regulation RELA EDN2 19616538 2124186 Ghrelin also significantly suppressed interleukin-1beta , tumor necrosis factor-alpha , and mRNA expression , and *inhibited* [NF-kappaB] activation . Negative_regulation RELA EPHB2 15249201 1271357 However , in the presence of PD98,059 , an inhibitor of , and salicylic acid , an [NF-kappaB] inhibitor , the EPO induced morphological differentiation of astrocytes and expression of FGAP and EPO receptor were *reduced* . Negative_regulation RELA EPHB2 16242916 1532017 Consistently , inhibition of significantly *increased* IkappaB kinase (IKK) activity , IkappaBalpha phosphorylation , and nuclear translocation of [NF-kappaB] induced by VEGF , whereas overexpression of ERK resulted in the loss of these responses to VEGF . Negative_regulation RELA EPHB2 17322771 1706386 In addition , inhibitor , PD 98,059 , reversed BPA induced cell death and *restored* [NF-kappaB] activity . Negative_regulation RELA EPHB2 18442799 1900630 In this study , we show that and p38 MAP kinase are *involved* in the downregulation of cell surface TNF-R1 upon exposure to Ac-CHX and the subsequent inhibition of TNF-alpha induced [NF-kappaB] activation . Negative_regulation RELA EPHB2 19127075 2071315 Analysis of the signaling pathways responsible for RANTES production by Langerhans cells was performed by ELISA using N-acetyl-L-cysteine , SP600125 , SB203580 and PD98059 , which are specific *inhibitors* of [NF-kappaB] activation , JNK , p38 MAPK and , respectively , and was finally confirmed by Western blot analysis . Negative_regulation RELA EPHB2 19823174 2187312 Sulfur dioxide donor significantly downregulated Raf-1 , mitogen activated protein kinase kinase-1 ( MEK-1 ) and , and *inhibited* pulmonary vascular smooth muscle cell proliferation , collagen remodeling and pulmonary vascular endothelial cell [nuclear factor-kappaB (NF-kappaB)] , and intercellular adhesion molecule 1 ( ICAM-1 ) expressions . Negative_regulation RELA EPHB2 20093109 2226140 We also found that markedly *suppressed* [NF-kappaB] signaling as detected by the NF-kappaB reporter gene assay but had no effects on the degradation of IkappaBalpha or translocation of NF-kappaB . Negative_regulation RELA EPHB2 20403072 2282182 inhibition also *induced* I-kappaB phosphorylation and enhanced [nuclear factor (NF)-kappaB/DNA] binding activity , leading to expression of cellular inhibitors of apoptosis protein 2 ( c-IAP2 ) , a known nuclear factor-kappaB (NF-kappaB) regulated endogenous anti-apoptotic molecule . Negative_regulation RELA EPHB2 20537708 2279372 In conclusion , all these findings demonstrate a key *role* of and TLR4 in association with [NF-kappaB] in IL-10 modulation induced by T. cruzi and suggest that this regulatory effect involves parasite-DC interactions not described yet . Negative_regulation RELA EPHB2 21426933 2427294 Downregulation of uPA and uPAR , simultaneously by transfecting the cancer cells with bi-cistronic siRNA expressing plasmid ( pU ) *inhibited* radiation induced activation , nuclear translocation of [Rel-A] , NF-?B DNA binding activity , and MCP-1 expression . Negative_regulation RELA EPHB2 9092580 422122 Inhibition of tyrosine kinase activity with genistein ( 10 microg/ml ) as well as selective MAP kinase inhibition with the MEK-1 inhibitor PD98059 abolished the VLA-4 dependent tyrosine phosphorylation , *inhibited* [NF kappaB] nuclear binding , and abrogated tissue factor expression induced by both VLA-4 cross linking and adhesion to fibronectin in THP-1 cells and human peripheral blood monocytes . Negative_regulation RELA F2R 16467309 1548173 Activation of or PAR-2 promoted nuclear translocation and phosphorylation of p65-NF-kappaB , and thrombin induced but not PAR-2 induced [p65-NF-kappaB] phosphorylation was *reduced* by inhibition of MEK or p38MAPK . Negative_regulation RELA FAS 10580567 570098 Modulation of expression and *inhibition* of [NF-kappaB] activation can potentially be of therapeutic importance in multiple myeloma . Negative_regulation RELA FAS 11585763 866266 Neither pathway activation alone nor *inhibition* of [NF-kappaB] activity with IkappaB-super repressor was sufficient to induce apoptosis of prostate cancer cells . Negative_regulation RELA FAS 12855571 1149815 Importantly , up-regulation of Gadd45 beta by CD40 precedes induced caspase activation , as well as *up-regulation* of other [NF-kappa B-controlled] inhibitors of apoptosis such as Bcl-xL and c-FLIPL . Negative_regulation RELA FAS 12883671 1116461 However , the *role* of in induction of [NF-kappaB] activation in HCC cells is not well understood . Negative_regulation RELA FAS 12897127 1118132 Interestingly , a 59-amino-acid core that included NLS2 but not the C-terminal leucine zipper domain was necessary and sufficient to induce pathway activation , *inhibition* of [NF-kappaB] activity , and apoptosis . Negative_regulation RELA FAS 15117910 1252041 Hcy increased [NF-kappaB] DNA binding activity , and adenovirus mediated transfection of a Ikappa-B mutant ( Ikappa-B mt ) gene *inhibited* Hcy induced expression . Negative_regulation RELA FAS 16765090 1612554 ( CD95 ) ligation *inhibits* activation of [NF-kappa B] by targeting p65-Rel A in a caspase dependent manner . Negative_regulation RELA FAS 18039530 1828542 Of the several molecular targets , those receiving attention are p53 gene replacement , Bcl-2 downregulation , apoptosis by induced by TNF , the receptor system and TRAIL , and *inhibition* of [NF-kappaB] . Negative_regulation RELA FAS 9500443 490762 We demonstrate that ligation of ( Fas/APO1 ) , a potent apoptotic stimulus in lymphocytes , *results* in repression of [NF-kappaB] activity in Jurkat T cells by inducing the proteolytic cleavage of NF-kappaB p65 ( Rel A ) and p50 . Negative_regulation RELA FUT4 17410536 1736222 In an attempt to identify an effective therapeutic agent for pancreatic cancer , the authors studied the *role* of , a synthetic serine protease inhibitor , in the inhibition of [NF-kappaB] activation and the induction of apoptotic responses . Negative_regulation RELA FUT4 17410536 1736321 In a time dependent and dose dependent manner , *inhibited* IkappaBalpha phosphorylation and [NF-kappaB] activation , thereby inhibiting the antiapoptotic activity of NF-kappaB . Negative_regulation RELA HBEGF 16034135 1436446 Neither overexpression or inhibition of MEK , Ras , or Akt affected mediated *inhibition* of [NF-kappaB] activation . Negative_regulation RELA HES2 15836676 1397691 Similarly , could *inhibit* hepatic [NF-kappaB] and AP-1 activations . Negative_regulation RELA HES2 15943182 1415840 also down-regulated pulmonary proinflammatory cytokines ( TNF-alpha , IL-1beta , and IL-6 ) and mRNA expressions ( CINC and P-selectin ) , and *inhibited* pulmonary activities of [NF-kappaB] and AP-1 . Negative_regulation RELA HES2 16104441 1444728 also decreased the number of MPO positive cells induced by LPS and *inhibited* activation of [NF-kappaB] and AP-1 . Negative_regulation RELA HES2 16987337 1617817 130/0.4 can *inhibit* CLP induced neutrophil recruitment and subsequent ALI by attenuating cytokines/chemokines , adhesion molecule mediated inflammation and [NF-kappaB] activation . Negative_regulation RELA HES2 19166983 2038568 In addition , both and BL could *attenuate* the increase in TNF-alpha , IL-6 , MPO levels and [NF-kappaB] activation . Negative_regulation RELA HES2 19766237 2224583 also significantly *inhibited* [NF-kappaB] activation , and TLRs mRNA and protein levels in peripheral monocytes . Negative_regulation RELA HES2 20451670 2288447 Meanwhile , could significantly reduce TNF-alpha , IL-6 , and ICAM-1 mRNA , *inhibit* [NF-kappaB] activation , and down-regulate TLR2 and TLR4 expression in the brain . Negative_regulation RELA ID1 17012234 1641401 Here , by using a T cell line model , we demonstrate that expression *stimulates* basal levels of [NF-kappaB] activity and further enhances NF-kappaB activation upon T cell receptor ( TCR ) signaling achieved by anti-CD3 and anti-CD28 stimulation . Negative_regulation RELA IFI27 17702989 1788795 Overexpression of *enhanced* the LPS induced IkappaB-zeta , IL-12p40 and [NF-kappaB] promoter activities , while anti-sense ( AS ) RNA against Ifi202 strongly suppressed them in a monocytic cell line , RAW 264.7 . Negative_regulation RELA IGFBP1 9575170 502606 This differential induction of iNOS as compared with similar *activation* of [NF-kappaB] by inhibitors of indicates the involvement of different intracellular signaling events for the induction of iNOS in two cell types of the same animal species . Negative_regulation RELA IL1B 11445585 860062 Furthermore , lambda/iotaPKC and cPLA(2) phosphorylation was attenuated by phosphatidyinositol 3-kinase ( PI3-kinase ) inhibitors , which also reduced [NF-kappaB] activation in *response* to TNF-alpha and , indicating a role for PI3-kinase in these processes in human keratinocytes . Negative_regulation RELA IL1B 11976320 953994 CaMKKc and Akt overexpression decreases IRAK1 mediated [NF-kappaB] activity and its association with MyD88 in *response* to stimulation . Negative_regulation RELA IL1B 14503852 1144643 Astaxanthin also suppressed the serum levels of NO , PGE2 , TNF-alpha , and in LPS administrated mice , and *inhibited* [NF-kappaB] activation as well as iNOS promoter activity in RAW264.7 cells stimulated with LPS . Negative_regulation RELA IL1B 16148608 1455209 induced NF-kappaB activation in vascular smooth muscle cells , and the addition of GGA further *inhibited* this [NF-kappaB] activation . Negative_regulation RELA IL1B 16286467 1509598 induced H2O2 production in MCF-7 cells and clearance of this ROS through the expression of GPx-1 *reduced* [NFkappaB] transcriptional activation by inhibiting NIK mediated phosphorylation of IKKalpha . Negative_regulation RELA IL1B 16675961 1583971 Concomitantly , we demonstrated that EFs stimulation *induced* [NF-kappaB] nuclear translocation and DNA binding on IL-1beta promoter region whereas inhibition of NF-kappaB with the specific chemical inhibitor SN-50 or by overexpression of IkappaB , the endogenous inhibitor of NF-kappaB pathway , totally abolished EFs mediated mRNA overexpression . Negative_regulation RELA IL1B 16707097 1564047 *activated* the extracellular signal regulated kinase 1/2 ( ERK1/2 ) , and this activation was also enhanced by H ( 2 ) S. Inhibition of ERK1/2 activation by the selective inhibitor U0126 inhibited IL-1beta induced [NF-kappaB] activation , iNOS expression , and NO production either in the absence or presence of H ( 2 ) S . Negative_regulation RELA IL1B 17115116 1709119 Resveratrol , a polyphenolic , natural phytoalexin found with particularly high levels in grape skin and red wine is potent and specific inhibitor of TNF-alpha and *induced* [NF-kappaB] activation . Negative_regulation RELA IL1B 17136479 1747052 Investigation of *mediated* regulation of [NF-kappaB] activation in colonic cells reveals divergence between PKB and PDK transduced events . Negative_regulation RELA IL1B 17931811 1819696 In lipopolysaccharide (LPS) stimulated RAW264.7 cells , HMCO5 inhibited [NF-kappaB] activation as well as iNOS promoter activity , *inhibited* the secretion of TNF-alpha and , and directly inhibited the intracellular accumulation of reactive oxygen species . Negative_regulation RELA IL1B 18266467 1896060 Here we demonstrate that ectopic expression of B14 inhibited [NF-kappaB] activation in *response* to TNFalpha , , poly ( I:C ) , and PMA . Negative_regulation RELA IL1B 18669445 1973129 DPML significantly inhibited tumor necrosis factor alpha , , and cytokine induced neutrophil chemoattractant-1 levels , suppressed neutrophil infiltration and myeloperoxidase activity , and *inhibited* [NFkappaB] and p38 mitogen activated protein kinase activation in the lung . Negative_regulation RELA IL1B 18779659 1963175 The stimulation of lymphoid cells with TNF-alpha , , and LPS *resulted* in significant ROS production and [NF-kappaB] activation . Negative_regulation RELA IL1B 19273233 2045825 In vitro experiments showed that stimulation also significantly *reduced* the association of Tollip with IRAK-1 and increased [NF-kappaB] binding activity in neonatal cardiomyocytes . Negative_regulation RELA IL1B 19616538 2124188 Ghrelin also significantly suppressed , tumor necrosis factor-alpha , and endothelin-l mRNA expression , and *inhibited* [NF-kappaB] activation . Negative_regulation RELA IL1B 19748795 2153111 ZD 7155 also reduced the mRNA expression of TNF-alpha and , *inhibited* the activation of [NF-kappaB] and AP-1 , and improved lung histopathology . Negative_regulation RELA IL1B 20039418 2192708 Fasudil inhibited induced activation of NF-kappaB independent of the inhibition of IkappaBalpha degradation and nuclear translocation of NF-kappaB , and *inhibited* IL-1beta induced DNA binding of [NF-kappaB] . Negative_regulation RELA IL1B 9510209 491894 C3 transferase exoenzyme , an inhibitor of Rho , abolished BK-induced [NF-kappaB] activation at 10 microg/ml and significantly *inhibited* BK-stimulated synthesis at 5 microg/ml . Negative_regulation RELA IL1RL1 7629057 316540 Moreover , expression of the membrane bound protein in transiently transfected Jurkat cells did not *result* in activation of the transcription factor [NF-kappa B] following IL-1 beta treatment . Negative_regulation RELA ITGB2 14613935 1187969 Co-stimulating and CD11b with activating antibodies *resulted* in [NF-kappaB] activation by GM-CSF and IL-8 in suspended cells . Negative_regulation RELA JAG1 20052673 2211723 Consistent with these results , we found that the down-regulation of Notch-1 or *led* to decreased expression and the activity of [NF-kappaB] downstream genes such as MMP-9 , VEGF , and uPA , contributing to the inhibition of cell migration and invasion . Negative_regulation RELA LBP 15618154 1357614 Here , we report that human high-dose ( hd-LBP ) suppresses binding of both R-type and S-type LPS to CD14 and *inhibits* LPS induced nuclear translocation of [NF-kappaB] , although cellular uptake of R-type LPS was found to be increased by hd-LBP . Negative_regulation RELA MAP2K6 10428782 633241 Cell stress and mediated p38 MAP kinase activation *inhibit* tumor necrosis factor induced IkappaB phosphorylation and [NF-kappaB] activation . Negative_regulation RELA MAP2K6 10878013 722428 We found that a constitutive active -- > ERK pathway *inhibited* [NF-kappaB-driven] transcription . Negative_regulation RELA MAP2K6 11322796 807207 A inhibitor , PD98059 *enhances* IL-1 induced [NF-kappaB] activation by the enhanced and sustained degradation of IkappaBalpha . Negative_regulation RELA MAP2K6 11885780 894076 The *activations* of CREB and [NF-kappaB] were blocked by inhibitors of either p38 ( SB-203580 ) or ( PD-098059 ) , suggesting that they were events downstream of MAK kinase . Negative_regulation RELA MAP2K6 15688034 1376187 Inhibitors of phosphatidylinositol-3'-kinase and Src family kinases significantly inhibited HGF/SF mediated activation of NF-kappaB , while inhibitors of , protein kinase C , and p70 S6 kinase *had* a modest effect or no effect on [NF-kappaB] activity . Negative_regulation RELA MAP2K6 16498455 1624269 TAK1-DN , , and SB203580 , but not MKK3-DN , also *suppressed* RANKL stimulation of [NF-kappaB] transcription activity in a manner dependent on p65 phosphorylation on Ser-536 . Negative_regulation RELA MAP2K6 18176092 1883432 LTD ( 4 ) -induced MUC2 gene transcriptional activity was also suppressed by a G-protein inhibitor ( pertussis toxin ) , a protein kinase C ( PKC ) inhibitor ( bisindolylmaleimide ) , a mitogen activated protein/extracellular signal regulated kinase kinase ( ) inhibitor ( PD98059 ) , an extracellular signal regulated kinase-2 ( ERK-2 ) inhibitor ( AG126 ) and a [nuclear factor kappaB (NF-kappaB)] *inhibitor* . Negative_regulation RELA MAP2K6 19823174 2187318 Sulfur dioxide donor significantly downregulated Raf-1 , ( MEK-1 ) and p-ERK/ERK , and *inhibited* pulmonary vascular smooth muscle cell proliferation , collagen remodeling and pulmonary vascular endothelial cell [nuclear factor-kappaB (NF-kappaB)] , and intercellular adhesion molecule 1 ( ICAM-1 ) expressions . Negative_regulation RELA MAP2K6 20403072 2282188 inhibition also *induced* I-kappaB phosphorylation and enhanced [nuclear factor (NF)-kappaB/DNA] binding activity , leading to expression of cellular inhibitors of apoptosis protein 2 ( c-IAP2 ) , a known nuclear factor-kappaB (NF-kappaB) regulated endogenous anti-apoptotic molecule . Negative_regulation RELA MAP2K6 9446561 483524 Inhibition of LPS mediated as well as LPS and ceramide mediated induction of iNOS and *activation* of [NF-kappaB] by PD98059 , a specific inhibitor of activation of mitogen activated protein (MAP) kinase kinase ( ) , and FPT inhibitor II , a selective inhibitor of Ras farnesyl protein transferase , indicate that the Ras-MAP kinase pathway is involved in LPS-ceramide induced activation of NF-kappaB and induction of iNOS , and that ceramide mediated signaling events probably converge into the LPS modulated MAP kinase signaling pathway resulting in greater activation of NF-kappaB and iNOS induction . Negative_regulation RELA MMP7 17115023 1677214 We found statistically significant correlations between metastatic tumor spread and overexpression of , MMP10/2 , tissue *inhibitor* of metalloproteinase 3 , vascular endothelial growth factor ( VEGF ) , P38 , stromal [NF-kappaB] , and synaptophysin . Negative_regulation RELA NEDD9 7925300 273473 As an in vitro model we show that phosphorylation of *impedes* its ability to interact with [NF-kappa B] , as has been shown before for I kappa B alpha . Negative_regulation RELA NEDD9 9529315 496603 Loss of also *led* to enhanced constitutive p50 homodimer and inducible [NF-kappaB] activities in unstimulated and stimulated cells , respectively . Negative_regulation RELA NES 17603937 1765207 Results showed that *inhibited* [NF-kappaB] activation and nuclear translocation . Negative_regulation RELA PLAT 17717150 1801492 In conclusion , our results demonstrate that after MCAO the interaction between and LRP *results* in [NF-kappaB] activation in astrocytes and induction of inducible nitric-oxide synthase expression in the ischemic tissue , suggesting a cytokine-like plasminogen independent role for tPA during cerebral ischemia . Negative_regulation RELA PLAU 12679464 1077195 and matrix metalloproteinase-9 and enzyme activity and *suppressed* [NF-kappaB] DNA binding activity ( by ANOVA , P < 0.05 ) . Negative_regulation RELA PTGER2 20516073 2295204 Shear induced interleukin-6 synthesis in chondrocytes : *roles* of and EP3 in cAMP/protein kinase A- and PI3-K/Akt dependent [NF-kappaB] activation . Negative_regulation RELA RCAN1 16627481 1583051 Together , these findings suggest that thrombin mediated activation of endothelial cells involves an interplay between NFAT and [NF-kappaB] signaling pathways and their negative feedback *inhibitors* , and I-kappaB , respectively . Negative_regulation RELA RCAN1 17062574 1654645 To elucidate the molecular basis of these anti-inflammatory effects , we analyzed the *role* of in the regulation of [NF-kappaB] transactivation using glioblastoma cells stably transfected with DSCR1 .4 or its truncation mutants ( DSCR1.4- ( 1-133 ) and DSCR1 .4- ( 134-197 ) ) . Negative_regulation RELA S100B 20069545 2201281 Conversely , silencing expression in myoblast cell lines by RNA interference *resulted* in reduced [NF-kappaB] activity and enhanced MyoD , myogenin and MyHC expression and myotube formation . Negative_regulation RELA TGM2 16720350 1565294 Previously we showed that the overexpression of *resulted* in activation of [NF-kappaB] through polymerization of I-kappaBalpha . Negative_regulation RELA TGM2 18923241 1977477 The objective of the present study was to investigate the expression of TGase 2 in the human atherosclerotic human coronary artery , and the possible *roles* of in [NF-kappaB] activation . Negative_regulation RELA TLR7 17296788 1698889 We found that oxidized low-density lipoprotein ( oxLDL ) was the key active component responsible for this effect , as it could directly uncouple mediated signaling on CD8alpha ( - ) myeloid DCs and *inhibit* [NF-kappaB] nuclear translocation . Negative_regulation RELA TLR7 18617174 2019961 activation *results* in nuclear translocation of the transcription factor [Nuclear Factor-kappa B (NF-kappaB)] that controls the transcription of many inflammatory genes . Negative_regulation RELA TLR7 20308556 2238090 Using HEK293 cells transfected with murine TLR7 or TLR8 and a NF-kappaB luciferase reporter , we demonstrated that stimulation of TLR8- , but not , transfected cells with either VV or VV DNA *resulted* in substantial [NF-kappaB] activation , and that siRNA mediated knockdown of TLR8 expression in pDCs led to a complete ablation of VV-induced type I IFN production . Negative_regulation RELA TNF 10085086 599364 Expression of the mutant NFkappaB completely inhibited [NFkappaB] DNA binding activity and *inhibited* both induced up-regulation of Bcl-2 and Bcl-x expression and neuroprotective effect . Negative_regulation RELA TNF 10414954 631096 receptor activation *results* in activation of the transcription factor [nuclear factor kappaB (NF-kappaB)] , which may serve an antiapoptotic role via the induction of target genes manganese superoxide dismutase ( MnSOD ) and/or calbindin . Negative_regulation RELA TNF 10416612 631439 In UM-SCC-9 cells that stably expressed IkappaBalphaM , inhibition of constitutive and *induced* [NF-kappaB] activation , and production of all four cytokines was observed . Negative_regulation RELA TNF 10795524 689676 Furthermore , neutralisation of residual activity or *inhibition* of [NF-kappaB] activation largely restored the inhibitory effect of IL-4 . Negative_regulation RELA TNF 10799332 691169 Inhibition of [NF-kappaB] in the *presence* of is supposed to be a promising cancer therapeutic approach , since it disrupts the protective mechanism of NF-kappaB activated by TNF . Negative_regulation RELA TNF 10820260 694382 Vesnarinone also blocked [NF-kappa B] activation induced by several other inflammatory agents , *inhibited* the induced activation of transcription factor AP-1 , and suppressed the TNF induced activation of c-Jun N-terminal kinase and mitogen activated protein kinase kinase . Negative_regulation RELA TNF 10959811 726330 Pretreatment of rats with DDB prevented LPS induced hepatic I-kappaBalpha degradation and the resultant [NF-kappaB] activation , and *inhibited* the LPS induced plasma TNF-alpha protein and hepatic mRNA expression in a dose dependent manner . Negative_regulation RELA TNF 10993753 733450 Stimulation of myocytes with *resulted* in a 12.1-fold increase ( P < 0.01 ) in [NF-kappa B-dependent] gene transcription and DNA binding compared with controls . Negative_regulation RELA TNF 11198351 779648 Stimulation of control cells with *resulted* in reactive oxygen species ( ROS ) generation and activation of [NF-kappaB] binding to the ICAM-1 promoter and ICAM-1 transcription . Negative_regulation RELA TNF 11274209 819036 However , the signal transduction pathways regulating [NF-kappaB] activation in human neutrophils in *response* to stimulation with are undefined . Negative_regulation RELA TNF 11289659 800576 GSNO ( 500 microM ) decreased induced NFkappaB activity ( p < 0.05 ) and *inhibited* [NFkappaB] activity whether given prior to or during TNFalpha exposure . Negative_regulation RELA TNF 11382928 820952 However , in transformed MEC , [NFkappaB] binding was initially undetectable but then increased in *response* to . Negative_regulation RELA TNF 11445585 860028 Atypical lambda/iota PKC conveys 5-lipoxygenase/leukotriene B4-mediated cross-talk between phospholipase A2s regulating [NF-kappa B] activation in *response* to and interleukin-1beta . Negative_regulation RELA TNF 11445585 860061 Furthermore , lambda/iotaPKC and cPLA(2) phosphorylation was attenuated by phosphatidyinositol 3-kinase ( PI3-kinase ) inhibitors , which also reduced [NF-kappaB] activation in *response* to and IL-1beta , indicating a role for PI3-kinase in these processes in human keratinocytes . Negative_regulation RELA TNF 11479295 860536 In contrast , *induced* IKK activity rapidly and transiently resulting in IkappaBalpha degradation and [NF-kappaB] activation . Negative_regulation RELA TNF 11689467 876279 Furthermore , LA dose-dependently inhibited *induced* IkappaB kinase activation , subsequent degradation of IkappaB , the cytoplasmic [NF-kappaB] inhibitor , and nuclear translocation of NF-kappaB . Negative_regulation RELA TNF 11752021 898654 Electrophoretic mobility shift assays demonstrated that NO donors repressed IP-10 gene transcription *induced* by IFN-gamma plus through the inhibition of [NF-kappaB] activation . Negative_regulation RELA TNF 11820362 908781 Transfection of NFkappaB and C/EBPbeta-sensitive reporter promoter constructs demonstrated that [NFkappaB] activity was enhanced and that constitutive C/EBPbeta was *inhibited* by , with both effects being p38 MAPK dependent . Negative_regulation RELA TNF 11837326 911507 This was further reinforced by the demonstration that herbimycin A , a tyrosine kinase inhibitor , *prevented* [NF-kappaB] activation by photosensitization but not by , a cytokine known to activate NF-kappaB through an IKK dependent mechanism . Negative_regulation RELA TNF 11991979 938618 Inhibition of alpha *induced* [NF-kappa B] activation by the adenovirus E3-10.4/14.5K complex . Negative_regulation RELA TNF 12175093 974554 Ketamine significantly reduced the LPS induced [NFkappaB] activation and *inhibited* production in a dose dependent manner . Negative_regulation RELA TNF 12356823 994049 Exposure to NaOCl ( 0.75 mM ) for 10 minutes caused suppression of *induced* increases in IL-1alpha mRNA and protein , declines in [NFkappaB] nuclear transfer , and a modification of IkappaBalpha , based on a bandshift detected by Western blot analysis . Negative_regulation RELA TNF 12485424 1024924 Inhibition of *stimulated* [NFkappaB/p65] in human keratinocytes by alpha-melanocyte stimulating hormone and adrenocorticotropic hormone peptides . Negative_regulation RELA TNF 12517920 1071012 Inhibition of alpha *mediated* [NFkappaB] activation and leukocyte adhesion , with enhanced endothelial apoptosis , by G protein linked receptor ( TP ) ligands . Negative_regulation RELA TNF 12709429 1112679 The *role* of receptor associated factor ( TRAF)-1 in [NF-kappaB] activation by various members of the TNF receptor family is not well understood , and conflicting data have been published . Negative_regulation RELA TNF 12871593 1114138 *Activation* of [NF-kappaB] as well as C/EBPbeta by p40 and inhibition of p40 induced expression of by Deltap65 , a dominant negative mutant of p65 , and DeltaC/EBPbeta , a dominant negative mutant of C/EBPbeta , suggests that p40 induces the expression of TNF-alpha through the activation of NF-kappaB and C/EBPbeta . Negative_regulation RELA TNF 14503852 1144642 Astaxanthin also suppressed the serum levels of NO , PGE2 , , and IL-1beta in LPS administrated mice , and *inhibited* [NF-kappaB] activation as well as iNOS promoter activity in RAW264.7 cells stimulated with LPS . Negative_regulation RELA TNF 14572618 1155840 In contrast , either the proteasome inhibitor carbobenzoxy-L-leucy-L-leucy-L-leucinal ( MG 132 ) or the IkappaBalpha inhibitor BAY 11-7082 ablated induced ICAM-1 gene expression and MG132 *inhibited* TNFalpha induced [NFkappaB] complexes . Negative_regulation RELA TNF 14584760 1159104 Treatment of rats with HES ( 3.75 and 7.5 ml/kg ) prevented LPS induced [NF-kappaB] activation , and *inhibited* , in a dose related manner , LPS induced and CINC expression . Negative_regulation RELA TNF 14607933 1162140 TNF-alpha treatment induces a more robust activation of [NF-kappaB] in STAT-1alpha-deficient cells , and restoration of STAT-1alpha *inhibits* dependent NF-kappaB activation . Negative_regulation RELA TNF 14766965 1212042 Furthermore , the activation of [NF-kappaB] by TAB3 was *blocked* by the NF-kappaB inhibitor , SN50 , and by expression of dominant negative forms of alpha associated factor 6 and transforming growth factor beta activated kinase . Negative_regulation RELA TNF 15068390 1184287 Removal of after stimulation *resulted* in a faster decrease in both [NF-kappa B] DNA binding activity and I kappa B-alpha mRNA levels . Negative_regulation RELA TNF 15322736 1287028 In vivo treatment with cloricromene ( 2 mg/kg/i.v. ) 30 min before lipopolysaccharide administration reversed the LPS induced loss in tone of the aortic rings , improved their reactivity to phenylephrine , decreased both nitric oxide ( NO ) and serum levels by inhibiting LPS induced inducible NO synthase and TNF-alpha mRNA expression , and interestingly *inhibited* LPS induced [NF-kappaB] activation . Negative_regulation RELA TNF 15538942 1336713 Rat seminiferous tubule segments were cultured in the presence and absence of , infliximab and SN50 , a [NF-kappa B] *inhibitor* . Negative_regulation RELA TNF 15653317 1364399 Recently , the underlying mechanism by which A20 downregulates [NF-kappaB] activation in *response* to the pro-inflammatory cytokine has been described . Negative_regulation RELA TNF 15659838 1350241 p7F also suppressed the serum level of in mice treated with collagen and *inhibited* nuclear factor-kappaB (NF-kappaB) activation as well as [NF-kappaB] promoter activity in RAW 264.7 cells stimulated with LPS . Negative_regulation RELA TNF 15660126 1369507 Herein , we demonstrate that both mediated repression and EGF mediated activation of EAAT2 expression *require* [NF-kappaB] . Negative_regulation RELA TNF 15760549 1383248 Glycine could efficiently protect rat liver grafts from ischemia-reperfusion injury by repressing the expression of CD14 and [NF-kappa B] binding activity in Kupffer cells and *inhibiting* the productions of and IL-1 . Negative_regulation RELA TNF 15833158 1397583 In IP , mutations in NEMO lead to the complete loss of [NF-kB] activation creating a susceptibility to cellular apoptosis in *response* to . Negative_regulation RELA TNF 15857826 1418934 On the other hand , [NFkappaB-p65] transcriptional activity was substantially *reduced* by , which targeted a trans-activation domain at the very C terminus of the p65 molecule . Negative_regulation RELA TNF 15870274 1404479 A prominent function of p62 is the regulation of [NF-kappaB] activation in *response* to interleukin-1 (IL-1) and signaling through the formation of an aPKC/p62/TRAF6 multiprotein signaling complex . Negative_regulation RELA TNF 16020286 1432117 Presence of the NF-kappaB inhibitor kamebakaurin in culture medium blocked P. aeruginosa induced [NF-kappaB] activation and *inhibited* IL-6 , IL-8 , and expression and secretion . Negative_regulation RELA TNF 16078585 1442534 The results indicated that thalidomide treatment significantly reduced colonic inflammation , suppressed [NF-kappaB] activation , enhanced TNF-alpha mRNA degradation , *inhibited* the synthesis of the , IEN-gamma and increased the production of IL-4 . Negative_regulation RELA TNF 16105982 1482166 Treatment with arsenic trioxide ( ATO ; 2-200 microM ) inhibited [NF-kappaB] activity in normal marrow , primary MDS , and ML1 cells , even in the *presence* of exogenous ( 20 ng/mL ) , and down-regulated NF-kappaB dependent antiapoptotic proteins , B-cell leukemia XL (Bcl-XL) , Bcl-2 , X-linked inhibitor of apoptosis (XIAP) , and Fas associated death domain (FADD)-like interleukin-1beta converting enzyme ( FLICE ) inhibitory protein ( FLIP ) , leading to apoptosis . Negative_regulation RELA TNF 16110831 1445342 DATS could downregulate production and *inhibit* [NF-kappaB] activation in lamina propria mononuclear cells of inflammed mucosa , without any effect on the viability of colonic tissue cells . Negative_regulation RELA TNF 16192349 1468325 [RelA] repression of RelB activity *induces* selective gene activation downstream of receptors . Negative_regulation RELA TNF 16303143 1546887 Further , stimulation induced the degradation of IkappaB-alpha and *resulted* in the transcriptional activation of [NF-kappaB] . Negative_regulation RELA TNF 16536903 1536571 Addition of meloxicam into synovial fibroblast cultures inhibited dose-dependently mRNA expression for MMPs and TIMPs , which were *increased* by stimulation , through the suppression of [NF-kappaB] and AP-1 activation . Negative_regulation RELA TNF 16770837 1682201 ADMA ( 30 microM ) significantly increased the activity of NF-kappaB and elevated the levels of ICAM-1 and , and pre-treatment with rosiglitazone ( 10 or 30 microM ) markedly *inhibited* the increased activity of [NF-kappaB] and reduced the elevated levels of TNF-alpha and ICAM-1 induced by ADMA in cultured endothelial cells . Negative_regulation RELA TNF 16774932 1672076 PMA selectively causes the degradation of IkappaB kinases ( IKKs ) including IKK-gamma and IKK-beta , and subsequent inhibition of *induced* IKK and [NF-kappaB] activation in human colon cancer cell line HCT-116 , but not in other gastrointestinal tract cells . Negative_regulation RELA TNF 16953224 1700209 The expression of constitutively active NF-kappaB in HNSCC is mediated through the tumor necrosis factor (TNF) signaling pathway , as [NF-kappaB] reporter activity was *inhibited* by receptor associated death domain ( TRADD ) , DN-TNF receptor associated factor (TRAF)2 , DN-receptor interacting protein ( RIP ) , DN-transforming growth factor-beta activated kinase 1 ( TAK1 ) , DN-kappa-Ras , DN-AKT and DN-IKK but not by DN-TRAF5 or DN-TRAF6 . Negative_regulation RELA TNF 16965747 1616054 QGHXR can protect liver cells by down regulating the expressions of CD14 , TLR(4) and [NF-kappaB] and *inhibiting* expression . Negative_regulation RELA TNF 16987412 1628285 mediated activation of IKK-beta *resulted* in activation of [NF-kappaB] and was followed by up-regulation of the bona-fide target gene cyclin D1 . Negative_regulation RELA TNF 17115116 1709118 Resveratrol , a polyphenolic , natural phytoalexin found with particularly high levels in grape skin and red wine is potent and specific inhibitor of and IL-1beta *induced* [NF-kappaB] activation . Negative_regulation RELA TNF 17253597 1710339 Co-incubation of MPM cells with and pyrrolidine dithiocarbamate ( PDTC ) , an [NF-kappaB] *inhibitor* , prevented TNF mediated up-regulation of IAP gene expression levels . Negative_regulation RELA TNF 17851586 1858278 CYLD protein harboring this missense mutation had a significant reduced ability to *inhibit* TNF receptor associated factor (TRAF)2- and TRAF6 mediated [NF-kappaB] activation , induced JNK signaling , and to deubiquitinate TRAF2 . Negative_regulation RELA TNF 17931811 1819695 In lipopolysaccharide (LPS) stimulated RAW264.7 cells , HMCO5 inhibited [NF-kappaB] activation as well as iNOS promoter activity , *inhibited* the secretion of and IL-1beta , and directly inhibited the intracellular accumulation of reactive oxygen species . Negative_regulation RELA TNF 17934460 1819718 Using genetic and molecular approaches , we show that Birc2 positively regulates the formation of the receptor complex I in endothelial cells , thereby *promoting* [NF-kappaB] activation and maintaining vessel integrity and stabilization . Negative_regulation RELA TNF 17953529 1814634 The mice with colitis treated by AN showed less tissue damage , less MPO activity , less production in colon , and *inhibited* [NF-kappaB] activation in LPMC , compared with those mice with colitis untreated , whereas the mice with colitis treated by CHD showed the worst tissue damage , the highest MPO activity , the highest TNF-alpha level , and enlarged NF-kappaB activation in LPMC . Negative_regulation RELA TNF 17959522 1814948 Compared to that of the control group , activity of pulmonary NF-kappaB in burned rats was markedly increased within 1 PBH and kept increasing till 24 h. Expressions of pulmonary and IL-8 mRNAs increased gradually , reaching the peak level at 6 PBH , and PDTC could effectively *inhibit* pulmonary [NF-kappaB] activation and expression of the pulmonary cytokines induced by the burn injury . Negative_regulation RELA TNF 17975552 1850168 We show in this study that R-Roscovitine can downregulate [nuclear factor-kappa B (NF-kappaB)] activation in *response* to and interleukin 1 . Negative_regulation RELA TNF 18040799 1669141 *Activation* of [NF-kappaB] by TNF-alpha and inhibition of induced BDNF expression by Deltap65 ( a dominant negative mutant ) and NEMO binding domain peptide ( an inhibitor of NF-kappaB ) suggests that TNF-alpha induces BDNF expression through the activation of NF-kappaB . Negative_regulation RELA TNF 18056399 1833528 Notably , stimulation of HEK293T cells with or overexpression of the p65 subunit of NF-kappaB *resulted* in up-regulation of NLRP2 and the formation of [NF-kappaB-NLRP2] promoter complexes . Negative_regulation RELA TNF 18064709 1937868 It is also suggested that TNF-alpha activates [NF-kappaB] and increases transgene expression by pDNA having many NF-kappaB binding sites , but also *reduces* transgene expression at later time periods , leading to short-term transgene expression . Negative_regulation RELA TNF 18178551 1875721 Thus we conclude that endogenous Cezanne can attenuate [NF-kappaB] activation and the induction of pro-inflammatory transcripts in *response* to signaling . Negative_regulation RELA TNF 18266467 1896059 Here we demonstrate that ectopic expression of B14 inhibited [NF-kappaB] activation in *response* to , IL-1beta , poly ( I:C ) , and PMA . Negative_regulation RELA TNF 18385389 1925577 MT downregulated the mRNA level , and PDTC *inhibited* the increases in both [NF-kappaB] translocation and TNF-alpha mRNA . Negative_regulation RELA TNF 18567808 1929754 As examined by DNA binding , we found that TQ suppressed induced NF-kappa B activation in a dose- and time dependent manner and *inhibited* [NF-kappaB] activation induced by various carcinogens and inflammatory stimuli . Negative_regulation RELA TNF 18779659 1963174 The stimulation of lymphoid cells with , IL-1beta , and LPS *resulted* in significant ROS production and [NF-kappaB] activation . Negative_regulation RELA TNF 19043589 1998948 However , exposure of macrophages and human monocytes to FHA for two hours or more resulted in the accumulation of cytosolic IkappaB alpha , and the failure of to *activate* [NF-kappaB] . Negative_regulation RELA TNF 19063961 2030174 [NF-kappaB] activation products such as Bcl-2 , Bcl-X ( L ) , cFLIP ( S ) , cFLIP ( L ) , and Mn-SOD were *reduced* by plus PY and restored by 1400W or NAC . Negative_regulation RELA TNF 19086324 2000283 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 MAPK and [NF-kappaB] activities , and then overexpression , thus alleviating the inflammatory reaction . Negative_regulation RELA TNF 19182383 2033249 Mangiferin also reduced acetylcholine and levels induced by scopolamine in mice brain ( p < 0.05 ) and *inhibited* [nuclear factor (NF)-kappaB] activation in scopolamine or TNF-alpha stimulated BV-2 microglial cells . Negative_regulation RELA TNF 19284955 2046498 ( 1 microg/L ) strongly induced the expression of NF-kappaB by approximately 1.76-fold compared with the control in the nuclei of A549 cells , and the induced [NF-kappaB] expression was significantly *suppressed* by addition of Feiyanning ( P < 0.01 ) . Negative_regulation RELA TNF 19287455 2055882 It has been shown that stimulation *leads* to degradation of TNF receptor associated factor-2 (TRAF2) and inhibition of TNFR1 induced activation of [NFkappaB] and JNK . Negative_regulation RELA TNF 19405981 2082344 GSK-3 inhibition reduced both basal and *induced* [NF-kappaB] luciferase activity . Negative_regulation RELA TNF 19409903 2082515 Although TNFalpha induced receptor interacting protein 1 ubiquitination is indeed impaired in T2/5 DKO cells , stimulation further *increases* IKK activity in these cells , resulting in significantly elevated expression of [NF-kappaB] target genes to a level higher than that in wild-type cells . Negative_regulation RELA TNF 19420112 2106629 However , the broad-spectrum caspase inhibitor Boc-d-fmk reduced [NF-kB] activation as assessed by gel shift assay , reduced phosphorylation of subunit IkappaBalpha , and significantly *inhibited* induced expression of ICAM-1 and VCAM-1 as assessed by both real-time PCR and flow cytometry . Negative_regulation RELA TNF 19616538 2124184 Ghrelin also significantly suppressed interleukin-1beta , , and endothelin-l mRNA expression , and *inhibited* [NF-kappaB] activation . Negative_regulation RELA TNF 19748795 2153110 ZD 7155 also reduced the mRNA expression of and IL-1 beta , *inhibited* the activation of [NF-kappaB] and AP-1 , and improved lung histopathology . Negative_regulation RELA TNF 20030669 2287270 In the ARDS model , vitamin K3 also suppressed the LPS induced increase in the serum level and *inhibited* the LPS evoked nuclear translocation of [NF-kappaB] in lung tissue . Negative_regulation RELA TNF 20451670 2288445 Meanwhile , HES could significantly reduce , IL-6 , and ICAM-1 mRNA , *inhibit* [NF-kappaB] activation , and down-regulate TLR2 and TLR4 expression in the brain . Negative_regulation RELA TNF 22654792 2522767 We also show that the signaling *reduces* the level of inhibitory nuclear factor kappa B protein subtype A ( NFKBIA ) , leading to the nuclear translocation of two NFKB dimers , p50/p50 , and [p50/RelA] . Negative_regulation RELA TNF 23066265 2685776 Doxycycline , nonsteroidal anti-inflammatory drugs ( NSAIDs ) , bisphosphonates , nitrous oxide ( NO ) synthase inhibitors , recombinant human interleukin-11 ( rhIL-11 ) , omega-3 fatty acid , mouse anti-human interleukin-6 receptor antibody ( MRA ) , mitogen activated protein kinase (MAPK) inhibitors , [nuclear factor-kappa B (NF-kb)] *inhibitors* , osteoprotegerin , and tumor necrosis factor antagonist ( ) are some of the therapeutic agents that have host modulation properties . Negative_regulation RELA TNF 24331632 2880524 Effects on the *induced* inhibitor of [NF-kB] ( IkBa ) activity ( phosphorylation status ) and its formation of adducts were detected by western blotting and immunoprecipitation . Negative_regulation RELA TNF 7594489 334760 The effect of LPS and is *mediated* by their ability to induce nuclear translocation of the DNA binding heterodimer [NF-kappa B] ( p50/p65 ) , which binds to a specific sequence in the HIV-long terminal repeat . Negative_regulation RELA TNF 7929839 274674 Both PDTC and HMAP attenuated the increase in nuclear [NF-kB] in *response* to either or IgG complexes . Negative_regulation RELA TNF 7929839 274678 Preincubation of cells with 8 br-cAMP , forskolin , or PGE2 attenuated the increase in nuclear [NF-kB] in *response* to , aggregated IgG , or superoxide anion . Negative_regulation RELA TNF 8207202 261383 However , only ( but not IL-2 ) efficiently *recovered* the nuclear [NF-kappa B] levels . Negative_regulation RELA TNF 8334993 223781 We describe here that in porcine aortic endothelial cells , either IL-1 alpha , or LPS *upregulates* an inhibitor of [NF kappa B] which we refer to as ECI-6 . Negative_regulation RELA TNF 8622650 354387 ( iii ) the C-terminal 40 residues of I kappa B alpha ( amino acids 277 to 317 ) , which include a PEST-like domain , are entirely dispensable for *induced* degradation and inhibition of [RelA] ; Negative_regulation RELA TNF 8900181 393447 Electrophoretic mobility shift assays with nuclear extracts of A3 cells showed that stimulation with ATRA and for more than 16 h *resulted* in enhanced [NF-kappaB] binding compared to that induced by TNF-alpha alone . Negative_regulation RELA TNF 9003392 404835 Exposure of rat Kupffer cells to a physiologically relevant concentration of lipopolysaccharide ( 10 ng/ml ) activated NF-kappa B within 1 h and induced the release of TNF-alpha over 5 h. Cellular glutathione content remained unchanged after lipopolysaccharide exposure , but both glutathione monoethyl ester and N-acetyl-L-cysteine increased cellular glutathione levels , blocked [NF-kappa B] activation and *inhibited* the release of . Negative_regulation RELA TNF 9438495 474993 also *prevented* [nuclear factor-kappa B (NF-kappa B)] activation , and a good correlation between this inhibition and inhibition of HIV replication was observed . Negative_regulation RELA TNF 9718198 528177 These results suggest that the rapid activation of NF-kappaB by is mainly due to the nuclear translocation of NF-kappaB pre existing in cytosol , and that the subsequent increase in the expression of p50 and p65 may *result* in the persistent activation of [NF-kappaB] during TNF-alpha stimulation . Negative_regulation RELA TNFSF10 10807904 736589 Overexpression of the tumor necrosis factor (TNF) related apoptosis inducing ligand ( ) receptors , TRAIL-R1 and TRAIL-R2 , *induces* apoptosis and activation of [NF-kappaB] in cultured cells . Negative_regulation RELA TNFSF10 16645643 1672029 Both addition of IGFBP-3 protein to cell cultures or enforced expression of IGFBP-3 in the HT29 carcinoma cell line inhibited [nuclear factor kappa B (NF-kappaB)] activation in *response* to the induction of apoptosis by . Negative_regulation RELB EPHB2 17705129 1789031 YopJ injection prevents up-regulation of the NF-kappaB [transcription factor Rel B] and *inhibits* activation -- both having key roles in DC differentiation . Negative_regulation RELB NEDD9 11687592 896241 Its cytosolic control is not affected by stimuli that lead to RelA nuclear translocation , and [RelB] nuclear localization is *prevented* by p100 , but not by or IkappaBalpha . Negative_regulation RELB TNF 12709443 1100435 Moreover , we show that RelB , p50 , and p100 can associate in the same complex and that but not LTbeta signaling *increases* the association of p100 with RelB/p50 dimers in the nucleus , leading to the specific inhibition of [RelB] DNA binding . Negative_regulation RELB TNF 16192349 1468326 RelA repression of [RelB] activity *induces* selective gene activation downstream of receptors . Negative_regulation REM1 TNF 3496800 75390 Recombinant also *suppressed* [rapid-eye-movement sleep (REM)] and induced biphasic fevers whether given by intravenous or ICV injection . Negative_regulation REN ALDH2 20697027 2312248 Furthermore , activation *inhibited* degranulation and [renin] release by reactive aldehydes in HMC-1 . Negative_regulation REN ANGPT1 3038386 76134 may possibly *inhibit* [renin] release in normal men . Negative_regulation REN EDN2 17068292 1649732 Additionally , both and thapsigargin *suppressed* cAMP levels and [renin] release in isoproterenol or forskolin pretreated As4.1 cells , a renin producing cell line that expresses AC5 and AC6 . Negative_regulation REN EDN2 19376621 2135559 receptor antagonism and [renin] *inhibition* as treatment options for scleroderma kidney . Negative_regulation REN EDN2 19376621 2135565 Both receptor antagonism and direct [renin] *inhibition* offer alternate novel therapies for patients with SRC . Negative_regulation REN EDN2 2232899 144661 also directly stimulates the release of aldosterone from the adrenal gland and *inhibits* [renin] release in vitro . Negative_regulation REN EDN2 2464732 104905 The endothelium derived vasoconstrictor peptide *inhibits* [renin] release in vitro . Negative_regulation REN EDN2 2678869 119495 The finding of a slight decrease in the plasma renin activity after the lower dose of endothelin , together with our previous finding that endothelin inhibits renin release from isolated rat glomeruli , suggests that *inhibits* [renin] release in vivo . Negative_regulation REN EDN2 2692455 124056 We previously reported that *inhibits* [renin] release in a dynamic superfusion system of collagenase dispersed rat renal cortical cells . Negative_regulation REN EDN2 2692455 124059 In the present report we investigated cellular mechanisms by which *inhibits* [renin] release from juxtaglomerular ( JG ) cells . Negative_regulation REN EDN2 2692455 124062 In a superfusion system of dispersed rat renal cortical cells , 10 ( -10 ) M *inhibited* [renin] release stimulated by 5 x 10 ( -8 ) M isoproterenol or 5 x 10 ( -5 ) M 8- ( N , N-diethylamino ) octyl-3,4,5-trimethoxybenzoate ( TMB-8 , a putative intracellular Ca antagonist ) . Negative_regulation REN EDN2 2692455 124065 Endothelin showed a slight but significant inhibitory effect on renin release stimulated by isoproterenol or TMB-8 even in the absence of extracellular Ca . also *inhibited* [renin] release in the presence of 10 ( -4 ) M nicardipine . Negative_regulation REN EDN2 2692455 124068 In a superfusion system of renal cortical slices , both 10 ( -8 ) M and a high concentration ( 60 mM ) of K *inhibited* [renin] release , and 10 ( -6 ) M nicardipine attenuated the inhibition of renin release by high K but did not affect the inhibition by endothelin . Negative_regulation REN EDN2 2692455 124074 These results suggest that *inhibits* [renin] release from JG cells not only by the promotion of Ca influx into the cells through dihydropyridine-insensitive Ca channels but also by other mechanism ( s ) independent of extracellular Ca . Negative_regulation REN EDN2 2698938 125119 In the isolated perfused rat kidney , *inhibits* [renin] release and reduces the renal perfusate flow . Negative_regulation REN EDN2 3052444 99491 *inhibits* [renin] release from isolated rat glomeruli . Negative_regulation REN EDN2 3052444 99497 Endothelin inhibited basal renin release in a dose dependent manner with an IC50 of 1.0 x 10 ( -9 ) M . also *inhibited* [renin] release stimulated by isoproterenol ( 10 ( -5 ) M ) . Negative_regulation REN EDN2 3052444 99503 These results suggest that *inhibits* [renin] release via a calcium entry mechanism and increases intracellular calcium . Negative_regulation REN EDN2 8434183 213000 Four distinct stimuli mediating renin release are ( 1 ) NaCl sensed at the macula densa , ( 2 ) the sympathetic nervous system , ( 3 ) humoral factors , with Ang II , vasopressin , , and adenosine *inhibiting* [renin] release , and ( 4 ) changes in intrarenal blood pressure . Negative_regulation REN EDN2 8445018 213744 Recent studies have demonstrated that the potent vasoconstrictive peptide *inhibits* the release of [renin] from renal juxtaglomerular cells , probably by a calcium dependent mechanism . Negative_regulation REN EDN2 8587343 341626 *inhibits* cAMP induced [renin] release from isolated renal juxtaglomerular cells . Negative_regulation REN EDN2 8682065 343271 Novel possibilities that have not yet been tested sufficiently in patients with heart failure include receptor antagonism , arginine vasopressin antagonism , and [renin] *inhibition* . Negative_regulation REN EDN2 8807579 382852 The adenylate cyclase activator forskolin ( 3 mumol/ liter ) increased [renin] mRNA levels to 400 % of the controls and this stimulation was dose-dependently *attenuated* by to 250 % of the control value . Negative_regulation REN EDN2 9186867 436893 Since endothelin is a potent mediator of Ca2+ influx and an inhibitor of renin release , we tested whether or not could be *involved* in the inhibitory effect of L-NAME on [renin] secretion . Negative_regulation REN EDN2 9857381 555448 Nitric oxide ( NO ) and ( ET-1 ) are *involved* in the regulation of [renin] release and modulate the vasoconstrictive and fibrogenic effects of angiotensin II . Negative_regulation REN IL1B 16959849 1639678 *attenuates* [renin] gene expression via a mitogen activated protein kinase kinase-extracellular signal regulated kinase and signal transducer and activator of transcription 3-dependent mechanism in As4.1 cells . Negative_regulation REN IL1B 16959849 1639679 can *repress* [renin] transcription under both baseline and retinoic acid stimulated conditions in As4.1 cells , a renin expressing cell line derived from the kidney . Negative_regulation REN IL1B 2104586 126827 TNF and recombinant human ( rhIL-i beta ) also *blocked* the inhibitory actions of angiotensin-II ( AII ) on [renin] release [ control , 100 +/- 3 % ; Negative_regulation REN IL1B 7829611 293467 Tumor necrosis factor-alpha and *inhibit* the synthesis and release of [renin] from human decidual cells . Negative_regulation REN PGC 8257128 238551 Human pepsin and were inhibited with Kis of 8 and 500 nM , respectively , and human [renin] was *inhibited* with a Ki of 190 microM . Negative_regulation REN RASD1 21247419 2386877 In addition , we demonstrated that shRNA mediated knockdown of *results* in further repression of Ear2 mediated [renin] transcription , whereas induction of Rasd1 by dexamethasone counteracts the effects of shRNA mediated Rasd1 knockdown . Negative_regulation REN TNF 12376397 996788 *inhibits* [renin] gene expression . Negative_regulation REN TNF 12376397 996790 *inhibited* [renin] gene expression via an inhibition of the transcriptional activity , targeting the proximal 4.1 kb of the renin promoter in As4.1 cells . Negative_regulation REN TNF 12376397 996791 also *attenuated* forskolin stimulated [renin] gene expression in primary cultures of mouse JG cells . Negative_regulation REN TNF 12376397 996792 Our data suggest that *inhibits* [renin] gene transcription at the cellular level and thus may act as a modulator of renin synthesis in ( physio ) pathological situations . Negative_regulation REN TNF 15857826 1418924 We have found that *suppresses* [renin] transcription via transcription factor NFkappaB , which targets a cAMP responsive element ( CRE ) in the renin promoter . Negative_regulation REN TNF 15857826 1418935 Our results suggest that *inhibits* [renin] gene expression by decreasing the transactivating capacity of NFkappaB-p65 and partially by attenuating CREB1 binding to CRE . Negative_regulation REN TNF 2104586 126830 These results suggest that IL-1 and are renin secretagogues and can also *block* the inhibitory actions of AII on [renin] . Negative_regulation REN TNF 7829611 293466 and interleukin-1 beta *inhibit* the synthesis and release of [renin] from human decidual cells . Negative_regulation RETN FOXO1 24291305 2898894 It can be regulated by transcriptional factors , but the possible *role* of forkhead transcription factor in regulating [resistin] gene expression is still unknown . Negative_regulation RETN TNF 16116950 1449112 It was concluded that could *inhibit* the expression of [resistin] in 3T3-L1 adipocytes . Negative_regulation RETN TNF 18369347 1912827 Our results showed that *caused* a dose dependent reduction in [resistin] mRNA levels . Negative_regulation RETN TNF 18369347 1912831 Pretreatment with L-NAME and PBITU significantly reversed the *induced* downregulation of [resistin] expression , while treatment with SNP mimicked the inhibitory effect of TNF-alpha on resistin expression . Negative_regulation RETN TNF 18369347 1912834 Our data suggest that *suppresses* [resistin] expression by inducing iNOS expression , thus causing overproduction of NO , which downregulates resistin gene expression . Negative_regulation RETN TNF 19473519 2091148 stimulation increased resistin protein and mRNA expression and atorvastatin *inhibited* the induction of [resistin] by TNF-alpha . Negative_regulation RGS2 GIP 9794454 543052 In contrast , [RGS2] expression *inhibited* the induced cAMP response by 50 % , a response similar to that of cells desensitized by preincubation with 10 ( -7 ) M GIP . Negative_regulation RGS2 PTH 11996904 939166 Overnight treatment with 1 micromol/L PMA to deplete PKC did not affect subsequent RGS-2 induction by , but significantly *inhibited* PMA induced [RGS-2] expression . Negative_regulation RGS2 RUNX2 11968023 938208 Furthermore , overexpression of the osteoblast-specific transcription factor also *led* to a stimulation of [RGS-2] promoter activity . Negative_regulation RHO ADRB2 24605225 2925138 Our previous study showed that [Rho] guanine nucleotide dissociation inhibitor 2 ( RhoGDI2 ) overexpression *induced* ( ß2AR ) desensitization in airway smooth muscle cells . Negative_regulation RHO GPR115 12045195 968420 These data show for the first time that a , SSTR1 , *inhibits* the activation of [Rho] , the assembly of focal adhesions and actin stress fibers , and cell migration . Negative_regulation RHO GPR132 10951580 723792 expression *resulted* in activation of [Rho] , and transformation via G2A was suppressed by a dominant negative form of RhoA . Negative_regulation RHO GPR132 12045195 968409 These data show for the first time that a , SSTR1 , *inhibits* the activation of [Rho] , the assembly of focal adhesions and actin stress fibers , and cell migration . Negative_regulation RHO GPR87 12045195 968489 These data show for the first time that a , SSTR1 , *inhibits* the activation of [Rho] , the assembly of focal adhesions and actin stress fibers , and cell migration . Negative_regulation RHO SNCAIP 23125193 2699312 *reduces* [Rho] activation in wound repair and suppresses formation of the spindle midzone during cytokinesis . Negative_regulation RHOA EPHB2 12777392 1119829 Initiation and transduction of stretch induced [RhoA] and Rac1 *activation* through caveolae : cytoskeletal regulation of translocation . Negative_regulation RHOA GPR132 10951580 723794 expression resulted in activation of Rho , and transformation via G2A was *suppressed* by a dominant negative form of [RhoA] . Negative_regulation RHOA IFI27 15078817 1237617 Finally , we found that ( Kip1 ) binds to RhoA , thereby *inhibiting* [RhoA] activation by interfering with the interaction between RhoA and its activators , the guanine-nucleotide exchange factors ( GEFs ) . Negative_regulation RHOA IFI27 16489017 1524900 Expression of in MCF7 breast cancer cells *down-regulated* [RhoA] and increased motility , survival , and Akt levels without an effect on cell cycle distribution . Negative_regulation RHOA IFI27 18180298 1875795 Cyclin D1 is an important cell cycle regulator , but in cancer its overexpression also increases cellular migration mediated by KIP1 stabilization and [RhoA] *inhibition* . Negative_regulation RHOA IL1B 20380881 2266999 Attachment to these ECM molecules significantly increased *induced* activation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and inhibition of [RhoA] and Rho kinase ( ROCK ) , coincident with loss of focal adhesions and cellular morphological changes . Negative_regulation RHOA KANK4 18458160 1909423 Furthermore , *inhibits* insulin and active Akt dependent activation of [RhoA] through binding to 14-3-3 . Negative_regulation RHOA MMP28 22972461 2719917 Motility increase required Rac1 activation and [RhoA] inhibition and was *inhibited* by an inhibitor . Negative_regulation RHOA MMP7 22972461 2719932 Motility increase required Rac1 activation and [RhoA] inhibition and was *inhibited* by an inhibitor . Negative_regulation RHOA NEDD9 16394104 1527116 We find that increased HEF1 sustains RhoA activation , whereas depleted by siRNA *reduces* [RhoA] activation . Negative_regulation RHOA RGS16 16141214 1475495 However , [RhoA] activation by PMT was *inhibited* by RGS2 , , lscRGS , and dominant negative G(13) ( GA ) , indicating involvement of Galpha(12/13) in the PMT effect on RhoA . Negative_regulation RHOA RGS2 16141214 1475496 However , [RhoA] activation by PMT was *inhibited* by , RGS16 , lscRGS , and dominant negative G(13) ( GA ) , indicating involvement of Galpha(12/13) in the PMT effect on RhoA . Negative_regulation RHOA SPHK1 17114809 1677168 However , [RhoA] *activation* by TNF-alpha was not blocked by inhibition . Negative_regulation RHOA SRGN 20032306 2205154 Moreover , axon collapse and [RhoA] activation induced by LPA and myelin associated neurite inhibitor Nogo-A is attenuated in the *presence* of , although direct activation of the RhoA-Rho-PIP5K kinase pathway abolishes PRG5 -formed neurites . Negative_regulation RHOB TNF 22869204 2775111 and NO synthase are the target genes of nuclear factor-kappaB ( NF-?B ) , and overexpression of [RhoB] *increased* , whereas inhibition of RhoB decreased the basal and LPS activated transcriptional activity of NF-?B in the cells . Negative_regulation RIC3 SNAP25 18591430 1931356 However , overexpression inhibited exocytosis , and this inhibition could be *suppressed* by latrunculin B treatment or [RIC3] overexpression . Negative_regulation RIOK3 TNF 19557502 2157504 Here , we report that overexpression of RIOK3 inhibits *induced* NF-kappaB activation , but down-regulation of endogenous [RIOK3] expression by siRNA potentiates it . Negative_regulation RIT1 EPHB2 18332868 1925094 Consistently , VprBP depletion abolished the in vivo interaction of Merlin and [Roc1-Cullin4A-DDB1] , which resulted in Merlin stabilization and *inhibited* and Rac activation . Negative_regulation RNASE1 ACE 8486718 219118 In contrast to RNase A , onconase is resistant to two [RNase] *inhibitors* , placental ribonuclease inhibitor and . Negative_regulation RNASE1 ACP2 16949956 1610149 In vitro supply of As2O3 in the enzyme assay medium beyond 400 microM *resulted* in gradual inhibition of [RNase] and beyond 5 microM inhibition of activities . Negative_regulation RNASE1 AZGP1 10462714 640096 We believe that the *role* of in differentiation and its [RNase] activity are two likely suspects as agents of the inhibition of proliferation . Negative_regulation RNASE1 DMD 17895580 1802786 The cleavage activities of His tagged RnlA and the [RNase] LS activity in a cell extract were *inhibited* by encoded by T4 phage . Negative_regulation RNASE1 HSD17B10 23755257 2797782 The ( ABAD ) interaction does not *mediate* a specific inhibition of mitochondrial [RNase] P . Negative_regulation RNASE1 IGKV1-17 8548204 339829 overexpression of the entire rne gene *results* in a 3-fold increase in [RNase] E activity . Negative_regulation RNASE1 LSS 18095190 1847400 The method reported here utilized EDTA , , and CTAB to successfully *inhibit* [RNase] activities . Negative_regulation RNASE1 PRPH2 15708638 1373228 Time-dependence studies revealed that the compound is active independently on the order of its addition to the reaction mixture , and inhibition kinetics studies demonstrated that 1643 *inhibits* the [RNase] H activity noncompetitively , with a K ( I ) value of 17 microM . Negative_regulation RNASE1 PVR 743505 8592 It was shown that [RNase] *inhibitors* such as heparin , and rat liver cytoplasmic RNA were capable to stimulate the RNA release , while the natural inhibitor from liver cytosol failed to influence the RNA relase . Negative_regulation RNASE1 RNASE1 2292 3228 The other [RNAse] , eluted from CM-cellulose at 0.25 M KCl was not *inhibited* by or 5 mM MgCl2 and was much less sensitive to the endogenous inhibitor . Negative_regulation RNASE1 RNH1 8448385 213978 [RNase A] and angiogenin are strongly *inhibited* by human , whereas the RNase activity and tumour cell agglutination activity of SBL are not affected by this inhibitor . Negative_regulation RNASE1 RNH1 8486718 219117 In contrast to RNase A , onconase is resistant to two [RNase] *inhibitors* , and Inhibit-Ace . Negative_regulation RNASE1 RNH1 8969838 402729 RT-PCR is carried out ( i ) by rapidly freezing cells in the presence of ( [RNase] *inhibitor* ) plus dithiothreitol and ( ii ) by using extracts of 250 or fewer cells directly in the RT-PCR assay . Negative_regulation RNASE1 RRBP1 22902556 2682915 We find that Rrp6 stimulates Rrp44 [RNase] activities and that is *inhibited* by a mutation in the Rrp44 exoribonuclease active site in 11-subunit nuclear exosomes . Negative_regulation RNASE1 S100A6 7880181 289063 The hybrid duplex , prA18/d ( TTflU ) 6TT , was shown not to interact with RNase H , whereas ( xTTT ) 6 *inhibited* the [RNase] H activity ( Ki = 0.67 mkM ) . Negative_regulation RNASE1 TRAF3 10087233 599793 Those against PB1 and PB2 inhibited the cap-I dependent [RNase] activity , but those against PB2 alone slightly *inhibited* the binding activity . Negative_regulation RNASE1 TYR 11994277 961713 Replacing His-427 and with Ala and Asp-469 with Asn *resulted* in reduced [RNase] H activity in the presence of Mg ( 2+ ) , whereas in the presence of Mn ( 2+ ) these mutants displayed a lack of turnover . Negative_regulation RNASE1 TYR 8844858 387577 The *role* of 97 in the thermal stability of [RNase A] is large . Negative_regulation RNASE10 RNASE1 2292 3234 The other [RNAse] , eluted from CM-cellulose at 0.25 M KCl was not *inhibited* by or 5 mM MgCl2 and was much less sensitive to the endogenous inhibitor . Negative_regulation RNASE11 RNASE1 2292 3233 The other [RNAse] , eluted from CM-cellulose at 0.25 M KCl was not *inhibited* by or 5 mM MgCl2 and was much less sensitive to the endogenous inhibitor . Negative_regulation RNASE12 RNASE1 2292 3238 The other [RNAse] , eluted from CM-cellulose at 0.25 M KCl was not *inhibited* by or 5 mM MgCl2 and was much less sensitive to the endogenous inhibitor . Negative_regulation RNASE13 RNASE1 2292 3239 The other [RNAse] , eluted from CM-cellulose at 0.25 M KCl was not *inhibited* by or 5 mM MgCl2 and was much less sensitive to the endogenous inhibitor . Negative_regulation RNASE2 RNASE1 2292 3229 The other [RNAse] , eluted from CM-cellulose at 0.25 M KCl was not *inhibited* by or 5 mM MgCl2 and was much less sensitive to the endogenous inhibitor . Negative_regulation RNASE3 ITGB2 10529607 561991 , CD49d , and alpha4beta7 antibodies significantly *suppressed* [ECP] levels in the serum . Negative_regulation RNASE3 RNASE1 2292 3230 The other [RNAse] , eluted from CM-cellulose at 0.25 M KCl was not *inhibited* by or 5 mM MgCl2 and was much less sensitive to the endogenous inhibitor . Negative_regulation RNASE4 RNASE1 2292 3231 The other [RNAse] , eluted from CM-cellulose at 0.25 M KCl was not *inhibited* by or 5 mM MgCl2 and was much less sensitive to the endogenous inhibitor . Negative_regulation RNASE6 RNASE1 2292 3232 The other [RNAse] , eluted from CM-cellulose at 0.25 M KCl was not *inhibited* by or 5 mM MgCl2 and was much less sensitive to the endogenous inhibitor . Negative_regulation RNASE7 ACE 8486718 219134 In contrast to RNase A , onconase is resistant to two [RNase] *inhibitors* , placental ribonuclease inhibitor and . Negative_regulation RNASE7 ACP2 16949956 1610157 In vitro supply of As2O3 in the enzyme assay medium beyond 400 microM *resulted* in gradual inhibition of [RNase] and beyond 5 microM inhibition of activities . Negative_regulation RNASE7 AZGP1 10462714 640104 We believe that the *role* of in differentiation and its [RNase] activity are two likely suspects as agents of the inhibition of proliferation . Negative_regulation RNASE7 DMD 17895580 1802794 The cleavage activities of His tagged RnlA and the [RNase] LS activity in a cell extract were *inhibited* by encoded by T4 phage . Negative_regulation RNASE7 HSD17B10 23755257 2797790 The ( ABAD ) interaction does not *mediate* a specific inhibition of mitochondrial [RNase] P . Negative_regulation RNASE7 IGKV1-17 8548204 339837 overexpression of the entire rne gene *results* in a 3-fold increase in [RNase] E activity . Negative_regulation RNASE7 LSS 18095190 1847408 The method reported here utilized EDTA , , and CTAB to successfully *inhibit* [RNase] activities . Negative_regulation RNASE7 PRPH2 15708638 1373236 Time-dependence studies revealed that the compound is active independently on the order of its addition to the reaction mixture , and inhibition kinetics studies demonstrated that 1643 *inhibits* the [RNase] H activity noncompetitively , with a K ( I ) value of 17 microM . Negative_regulation RNASE7 PVR 743505 8600 It was shown that [RNase] *inhibitors* such as heparin , and rat liver cytoplasmic RNA were capable to stimulate the RNA release , while the natural inhibitor from liver cytosol failed to influence the RNA relase . Negative_regulation RNASE7 RNASE1 2292 3236 The other [RNAse] , eluted from CM-cellulose at 0.25 M KCl was not *inhibited* by or 5 mM MgCl2 and was much less sensitive to the endogenous inhibitor . Negative_regulation RNASE7 RNH1 8486718 219133 In contrast to RNase A , onconase is resistant to two [RNase] *inhibitors* , and Inhibit-Ace . Negative_regulation RNASE7 RNH1 8969838 402737 RT-PCR is carried out ( i ) by rapidly freezing cells in the presence of ( [RNase] *inhibitor* ) plus dithiothreitol and ( ii ) by using extracts of 250 or fewer cells directly in the RT-PCR assay . Negative_regulation RNASE7 RRBP1 22902556 2682935 We find that Rrp6 stimulates Rrp44 [RNase] activities and that is *inhibited* by a mutation in the Rrp44 exoribonuclease active site in 11-subunit nuclear exosomes . Negative_regulation RNASE7 S100A6 7880181 289071 The hybrid duplex , prA18/d ( TTflU ) 6TT , was shown not to interact with RNase H , whereas ( xTTT ) 6 *inhibited* the [RNase] H activity ( Ki = 0.67 mkM ) . Negative_regulation RNASE7 TRAF3 10087233 599813 Those against PB1 and PB2 inhibited the cap-I dependent [RNase] activity , but those against PB2 alone slightly *inhibited* the binding activity . Negative_regulation RNASE7 TYR 11994277 961721 Replacing His-427 and with Ala and Asp-469 with Asn *resulted* in reduced [RNase] H activity in the presence of Mg ( 2+ ) , whereas in the presence of Mn ( 2+ ) these mutants displayed a lack of turnover . Negative_regulation RNASE8 RNASE1 2292 3235 The other [RNAse] , eluted from CM-cellulose at 0.25 M KCl was not *inhibited* by or 5 mM MgCl2 and was much less sensitive to the endogenous inhibitor . Negative_regulation RNASE9 RNASE1 2292 3237 The other [RNAse] , eluted from CM-cellulose at 0.25 M KCl was not *inhibited* by or 5 mM MgCl2 and was much less sensitive to the endogenous inhibitor . Negative_regulation RNASEH1 RNASE1 11029655 739877 In the absence of [RNase H1] , H2 activity *increases* , and cells are sensitive to EMS but not HU and are more tolerant of caffeine ; Negative_regulation RNASEH1 RNASE7 11029655 739885 In the absence of [RNase H1] , H2 activity *increases* , and cells are sensitive to EMS but not HU and are more tolerant of caffeine ; Negative_regulation RNASEH2C GPR115 10969064 744809 The consensus peptide effectively *prevented* the binding of [AGS3] to Gialpha1,2 in protein interaction assays , inhibited guanosine 5'-O- ( 3-thiotriphosphate ) binding to Gialpha , and stabilized the GDP bound conformation of Gialpha . Negative_regulation RNASEH2C GPR132 10969064 744798 The consensus peptide effectively *prevented* the binding of [AGS3] to Gialpha1,2 in protein interaction assays , inhibited guanosine 5'-O- ( 3-thiotriphosphate ) binding to Gialpha , and stabilized the GDP bound conformation of Gialpha . Negative_regulation RNASEH2C GPR87 10969064 744878 The consensus peptide effectively *prevented* the binding of [AGS3] to Gialpha1,2 in protein interaction assays , inhibited guanosine 5'-O- ( 3-thiotriphosphate ) binding to Gialpha , and stabilized the GDP bound conformation of Gialpha . Negative_regulation RND2 NR2F1 21965613 2492698 We show that directly *represses* [Rnd2] expression at the post-mitotic level along the rostrocaudal axis of the neocortex . Negative_regulation RNF19A EPHB2 17637226 1770762 it also promoted the activation of during the early phase of reperfusion but *inhibited* the activation of p-JNK1/2 and [p-p38] following the 30-minute , 1-hour and 3-hour intervals of reperfusion . Negative_regulation RNF19A TNF 9535085 497056 The ability of the yopJ mutant to downregulate [p38] and JNK and to *inhibit* production of was restored by the expression of yopJ+ in trans . Negative_regulation ROCK1 CCND1 18180298 1875796 Additionally , whereas stabilized p27 KIP1 and *inhibited* RhoA induced [ROCK] kinase activity , promoting cellular migration , cyclin D1b failed to stabilize p27 KIP1 or inhibit ROCK kinase activity and had no effect on migration . Negative_regulation ROCK1 EPHB2 21166955 2378650 Thus , it is suggested that the anti-angiogenic effect of HA1077 may be due to the combination of [ROCK] inhibition and mitogen activated protein kinase kinase ( MEK ) pathway *inhibition* . Negative_regulation ROCK1 MAP2K6 12011049 962193 In normal rat kidney cells stably transformed by v-Src , we found that the chronic activation of *induces* down-regulation of [ROCK] expression , thereby uncoupling Rho from stress fiber formation . Negative_regulation ROCK1 MAP2K6 21166955 2378656 Thus , it is suggested that the anti-angiogenic effect of HA1077 may be due to the combination of [ROCK] inhibition and ( MEK ) /ERK pathway *inhibition* . Negative_regulation ROCK2 ANGPT1 19403408 2070398 can *inhibit* AngII induced activation of [Rock2] and reduce alpha-SMA expression in HSCs . Negative_regulation ROCK2 CCND1 16705174 1560783 *repressed* [ROCKII] and TSP-1 expression , and the migratory defect of cyclin D1 ( -/- ) cells was reversed by ROCK inhibition or TSP-1 immunoneutralizing antibodies . Negative_regulation ROCK2 CCND1 18180298 1875798 Additionally , whereas stabilized p27 KIP1 and *inhibited* RhoA induced [ROCK] kinase activity , promoting cellular migration , cyclin D1b failed to stabilize p27 KIP1 or inhibit ROCK kinase activity and had no effect on migration . Negative_regulation ROCK2 EPHB2 21166955 2378658 Thus , it is suggested that the anti-angiogenic effect of HA1077 may be due to the combination of [ROCK] inhibition and mitogen activated protein kinase kinase ( MEK ) pathway *inhibition* . Negative_regulation ROCK2 FAS 23283363 2741940 Animals were implanted with an intracerbroventricular cannula and osmotic minipump ( rate , 1 µL/h ) containing sterile saline , 1.5 µg/kg per day fasudil ( , a [ROCKII] *inhibitor* ) for 4 days or Fas+100 µg/kg per day N?-Nitro-l-arginine methyl ester hydrochloride , a NO synthase inhibitor . Negative_regulation ROCK2 MAP2K6 12011049 962200 In normal rat kidney cells stably transformed by v-Src , we found that the chronic activation of *induces* down-regulation of [ROCK] expression , thereby uncoupling Rho from stress fiber formation . Negative_regulation ROCK2 MAP2K6 21166955 2378664 Thus , it is suggested that the anti-angiogenic effect of HA1077 may be due to the combination of [ROCK] inhibition and ( MEK ) /ERK pathway *inhibition* . Negative_regulation RORC IDO1 17947673 1814359 Functional yet balanced reactivity to Candida albicans requires TRIF , MyD88 , and dependent *inhibition* of [Rorc] . Negative_regulation RORC IL6 20015694 2204419 IFN-alpha did not affect the production of TGF-beta or , but *inhibited* [RORC] mRNA expression of anti-CD3 stimulated CD4+ T cells . Negative_regulation RORC PDS5B 22617429 2625403 In addition , specifically *reduces* mRNA levels of the retinoic related orphan [receptor (ROR)C] gene which encodes ROR?t , a key transcription factor controlling optimal IL-17 expression in fully differentiated Th17 cells . Negative_regulation RPF1 EDN2 2138667 129003 markedly *reduced* [renal perfusate flow (RPF)] as a result of its potent renal vasoconstrictor effect . Negative_regulation RPF1 EDN2 8304480 249004 In the isolated perfused rat kidney , added to the perfusate at concentrations ranging from 50 to 500 pmol/l *resulted* in a dose dependent reduction in [renal perfusate flow (RPF)] and inulin clearance ( CIn ) . Negative_regulation RPF2 EDN2 2138667 129000 markedly *reduced* [renal perfusate flow (RPF)] as a result of its potent renal vasoconstrictor effect . Negative_regulation RPF2 EDN2 8304480 249001 In the isolated perfused rat kidney , added to the perfusate at concentrations ranging from 50 to 500 pmol/l *resulted* in a dose dependent reduction in [renal perfusate flow (RPF)] and inulin clearance ( CIn ) . Negative_regulation RPL13A DAPK1 18995835 1990127 Inhibition of and ZIPK facilitates cell restoration to the basal state and *allows* renewed induction of [GAIT] target transcripts by repeated stimulation . Negative_regulation RPS27 TNF 22025632 2508057 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation RPS6KA1 IL1B 10965886 728064 IL-1beta and cAMP did not change the half-life of IGFBP-1 mRNA , but PD98059 and SB202190 , a p38 MAP kinase inhibitor , destabilized IGFBP-1 mRNA and blocked the phosphorylation of [RSK-1] in *response* to . Negative_regulation RPS6KA3 EPHB2 11113199 768294 However , ERK2-Delta19-25 had no effect on the phosphorylation of RSK2 , an ERK2 cytoplasmic substrate , whereas a nonactivatable ( T183A ) that retained these sequences could *inhibit* [RSK2] phosphorylation . Negative_regulation RPS6KA6 CCND1 22614021 2763354 *inhibited* [RSK4] expression and serum starvation enhanced the inhibition , whereas c-Myc and RSK4 inhibited cyclin D1 . Negative_regulation RPSA EPHB2 20491781 2288866 Both and JNK inhibitors significantly *inhibited* hypoxia induced expression of [67LR] and the subsequent expression of uPA and MMP 9 . Negative_regulation RPTOR DAPK1 18974095 2015062 DAPK ( +/- ) mouse embryo fibroblasts have attenuated mTORC1 signaling compared with DAPK+/+ counterparts , and overexpression of in DAPK ( +/- ) MEFs *stimulates* [mTORC1] activity . Negative_regulation RPTOR EPHB2 22715163 2634051 Lovastatin alone significantly reduced MPC and MTT cell viability at therapeutically relevant doses and *inhibited* both and AKT signalling , but increased [mTORC1/p70S6K] signalling . Negative_regulation RPTOR EPHB2 23431403 2744408 Absence of kinase suppressor of Ras 1 (KSR1) , a scaffold protein of the ERK signaling pathway , or inhibition of *resulted* in decreased [mTORC1] activity following T cell activation . Negative_regulation RPTOR FBXO32 24002653 2856144 To accomplish this goal , in vivo transfection of plasmid DNA was used to create transient transgenic mouse skeletal muscles , and our results show for the first time that Smad3 expression is sufficient to stimulate promoter activity , *inhibit* [Akt/mTOR signaling] and protein synthesis , and induce muscle fiber atrophy . Negative_regulation RPTOR FOXO1 20412774 2246453 Activated *inhibits* [mTORC1] by TSC2 dependent and TSC2 independent mechanisms . Negative_regulation RPTOR FOXO1 20412774 2246470 Thus , under stress conditions , *inhibits* the anabolic activity of [mTORC1] , a major consumer of cellular energy , while activating Akt , which increases cellular energy metabolism , thereby maintaining cellular energy homeostasis . Negative_regulation RPTOR FOXO1 23800068 2802902 This hypothesis postulates that antiacne agents either enhance nuclear activity or *inhibit* [mTORC1] . Negative_regulation RPTOR TLR7 24251781 2903645 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , PI3K/AkT inhibition , IKK/JNK inhibition , [mTORC1] *inhibition* , JAK/STAT inhibition , suppression , and ACE inhibition . Negative_regulation RRBP1 RNASE1 22902556 2682920 We find that Rrp6 stimulates Rrp44 activities and that [Rrp6] is *inhibited* by a mutation in the Rrp44 exoribonuclease active site in 11-subunit nuclear exosomes . Negative_regulation RRBP1 RNASE7 22902556 2682928 We find that Rrp6 stimulates Rrp44 activities and that [Rrp6] is *inhibited* by a mutation in the Rrp44 exoribonuclease active site in 11-subunit nuclear exosomes . Negative_regulation RUNX1 CAPN8 19581587 2111631 Remarkably , inhibition *triggered* [AML1-ETO] degradation and impaired the clonogenic potential of the human t ( 8 ; 21 ) leukemic blood cell line Kasumi-1 . Negative_regulation RUNX2 EPHB2 23673010 2810952 Similar results were obtained in experiments performed in the native tissue in which inhibition of and p38 MAPK *increased* BK channel activity in the cortical [collecting duct (CCD)] treated with dynasore . Negative_regulation RUNX2 EPHB2 23775473 2901915 Bromopropane compounds inhibit osteogenesis by *dependent* [Runx2] inhibition in C2C12 cells . Negative_regulation RUNX2 FHL1 19230833 2086546 Inhibition of by RNA interference *resulted* in the decreased activity of [Runx2] in osteoblasts . Negative_regulation RUNX2 FOXO1 21471200 2433554 Electrophoretic mobility shift assay demonstrated that *suppressed* [Runx2] binding to its cognate site within the Bglap2 promoter . Negative_regulation RUNX2 FOXO1 21505104 2422973 *inhibits* [Runx2] transcriptional activity and prostate cancer cell migration and invasion . Negative_regulation RUNX2 IL1B 19302812 2052090 TNF-alpha and *inhibit* [RUNX2] and collagen expression but increase alkaline phosphatase activity and mineralization in human mesenchymal stem cells . Negative_regulation RUNX2 MAP2K6 10660618 664646 Furthermore , ( 32 ) P metabolic labeling studies demonstrated that MEK ( SP ) clearly *enhanced* phosphorylation of [Cbfa1] in intact cells , while ( DN ) decreased phosphorylation . Negative_regulation RUNX2 MAP2K6 20007706 2199942 In contrast , overexpression of constitutively active strongly *increased* the [Runx2] protein level , which paralleled an increase in Runx2 acetylation . Negative_regulation RUNX2 TNF 11723115 896994 Expression of the osteoblast differentiation factor [RUNX2] ( Cbfa1/AML3/Pebp2alpha A ) is *inhibited* by . Negative_regulation RUNX2 TNF 18310456 1879067 FPP and GGPP also restored the simvastatin effects on *induced* suppression of [Runx2] and ALP activity . Negative_regulation RUNX2 TNF 19302812 2052089 and IL-1beta *inhibit* [RUNX2] and collagen expression but increase alkaline phosphatase activity and mineralization in human mesenchymal stem cells . Negative_regulation RUNX2 TNF 20638987 2292238 In addition , *suppressed* BMP-2 induced [Runx2] and osteocalcin expression , and estradiol and dexamethasone reversed the TNF-alpha effects on BMP-2 induced Runx2 expression . Negative_regulation RXRA FOXO1 12966085 1158328 One mechanism by which Foxo1 antagonizes PPARgamma activity is through disruption of DNA binding as *inhibited* the DNA binding activity of a [PPARgamma/retinoid X receptor alpha] heterodimeric complex . Negative_regulation RXRA IL1B 12105223 976673 *mediated* suppression of [RXR:RAR] transactivation of the Ntcp promoter is JNK dependent . Negative_regulation RXRA IL1B 12105223 976677 Curcumin , but not PD98059 or SB203580 , inhibited *mediated* suppression of nuclear [RXR:RAR] binding activity , which correlated with inhibition of JNK phosphorylation and phospho-JNK mediated phosphorylation of RXR . Negative_regulation RYR1 CABP4 11751318 898257 We provide novel evidence that the sarcoplasmic reticulum , calsequestrin , *inhibits* native [ryanodine receptor] calcium release channel activity . Negative_regulation RYR1 CAPN8 11148048 770415 These results demonstrate that the NH ( 2 ) -terminus of the RyR is a molecular target for dantrolene , and suggest a regulatory *role* for both activity and ATP in the interaction of dantrolene with the [RyR] in vivo . Negative_regulation RYR2 CABP4 11751318 898262 We provide novel evidence that the sarcoplasmic reticulum , calsequestrin , *inhibits* native [ryanodine receptor] calcium release channel activity . Negative_regulation RYR2 CAPN8 11148048 770429 These results demonstrate that the NH ( 2 ) -terminus of the RyR is a molecular target for dantrolene , and suggest a regulatory *role* for both activity and ATP in the interaction of dantrolene with the [RyR] in vivo . Negative_regulation RYR3 CABP4 11751318 898267 We provide novel evidence that the sarcoplasmic reticulum , calsequestrin , *inhibits* native [ryanodine receptor] calcium release channel activity . Negative_regulation RYR3 CAPN8 11148048 770443 These results demonstrate that the NH ( 2 ) -terminus of the RyR is a molecular target for dantrolene , and suggest a regulatory *role* for both activity and ATP in the interaction of dantrolene with the [RyR] in vivo . Negative_regulation S100A12 ARSA 11323131 807252 , however , *attenuated* neurogenic inflammation , but not [CGRP] release , confirming the concept of prejunctional inhibition of CGRP release by 5-HT1B/1D receptors . Negative_regulation S100A12 IL1B 8764661 378586 This enhancement of the peptide release by LPS was blocked by IL-1beta tripeptide antagonist Lys-D-Pro-Thr ( 10 microM ) and mimicked by IL-1beta and TNF-alpha ( 10-100 pg/ml ) , suggesting that the potentiating effect of LPS on [CGRP] release is *mediated* by generation of and TNF-alpha . Negative_regulation S100A12 TNF 16927957 1603896 Studies in cultured trigeminal neurons demonstrate that CGRP is released from trigeminal ganglia cells , that CGRP transcription is increased under conditions mimicking neurogenic inflammation , that migraine pharmacotherapies can both reduce CGRP release and *inhibit* [CGRP] transcription , and that , an endogenous inflammatory mediator implicated in migraine , can stimulate CGRP transcription . Negative_regulation S100A12 TNF 8764661 378585 This enhancement of the peptide release by LPS was blocked by IL-1beta tripeptide antagonist Lys-D-Pro-Thr ( 10 microM ) and mimicked by IL-1beta and TNF-alpha ( 10-100 pg/ml ) , suggesting that the potentiating effect of LPS on [CGRP] release is *mediated* by generation of IL-1beta and . Negative_regulation S100A6 TNF 22025528 2533768 Inhibition of [S100A6] by IL24 was *dependent* on and induced acetylation of p53 followed by activation of the caspase 8-caspase 3 apoptotic pathway . Negative_regulation S100A7 BCL2 16082188 1481880 We also demonstrate that overexpression *represses* the induction of [psoriasin] and calgranulin-B under these different conditions . Negative_regulation S100A7 BCL2 16082188 1481882 The same effect was obtained with the antioxidant NAC , which indicates that the suppression of [psoriasin] and calgranulin-B induction is *mediated* by the antioxidant function of . Negative_regulation S100A7 BRCA1 16288014 1481174 and c-Myc associate to transcriptionally *repress* [psoriasin] , a DNA damage-inducible gene . Negative_regulation S100A7 BRCA1 16288014 1481177 Furthermore , we show that BRCA1 and c-Myc form a complex on the psoriasin promoter and that *mediated* repression of [psoriasin] is dependent on functional c-Myc . Negative_regulation S100A7 CTBP1 23000163 2689163 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Negative_regulation S100A7 CTNNB1 18223693 1919126 Furthermore , we demonstrated that [S100A7] is associated with the beta-catenin complex , and *inhibits* signaling by targeting beta-catenin degradation via a noncanonical mechanism that is independent of GSK3beta mediated phosphorylation . Negative_regulation S100A7 HDAC1 23000163 2689167 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Negative_regulation S100A7 HMG20A 23000163 2689168 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Negative_regulation S100A7 HMG20B 23000163 2689169 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Negative_regulation S100A7 HSPA1B 23000163 2689170 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Negative_regulation S100A7 ICAM1 20217214 2362672 Loss of signaling *induces* [psoriasin] ( S100A7 ) and MUC1 in mammary epithelial cells . Negative_regulation S100A7 IL13 18754038 2028273 Surprisingly , tumor necrosis factor-alpha enhanced [psoriasin] release in primary keratinocytes was *inhibited* by the Th2-cytokines , whereas IL-17 and -22 induced psoriasin . Negative_regulation S100A7 IL4 18754038 2028274 Surprisingly , tumor necrosis factor-alpha enhanced [psoriasin] release in primary keratinocytes was *inhibited* by the Th2-cytokines and -13 , whereas IL-17 and -22 induced psoriasin . Negative_regulation S100A7 KDM1A 23000163 2689166 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Negative_regulation S100A7 MYC 16288014 1481175 BRCA1 and associate to transcriptionally *repress* [psoriasin] , a DNA damage-inducible gene . Negative_regulation S100A7 MYC 16288014 1481178 Furthermore , we show that BRCA1 and c-Myc form a complex on the psoriasin promoter and that BRCA1 mediated repression of [psoriasin] is *dependent* on functional . Negative_regulation S100A7 PHF21A 23000163 2689162 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Negative_regulation S100A7 PHF21B 23000163 2689164 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Negative_regulation S100A7 RCOR1 23000163 2689161 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Negative_regulation S100A7 RCOR3 23000163 2689165 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Negative_regulation S100A7 RREB1 23000163 2689158 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Negative_regulation S100A7 ZMYM2 23000163 2689159 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Negative_regulation S100A7 ZNF217 23000163 2689160 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Negative_regulation S100B AQP4 23142267 2717882 Non-specific inhibitors of *stimulate* [S100B] secretion in acute hippocampal slices of rats . Negative_regulation S100B CD8A 21447379 2453476 Stimulation of S100B ( + ) CD3 ( + ) ( + ) lymphocytes with anti-CD3 or phytohaemagglutinin *resulted* in release of [S100B] . Negative_regulation S100B CD8B 21447379 2453477 Stimulation of S100B ( + ) CD3 ( + ) ( + ) lymphocytes with anti-CD3 or phytohaemagglutinin *resulted* in release of [S100B] . Negative_regulation S100B IL1A 11754999 890223 Astrocytic overexpression of [S100B] , in turn , is *promoted* by high levels of , originating from activated microglia that are also constant components of Abeta plaques in Alzheimer 's disease . Negative_regulation S100B INS 18840784 2012943 or TDZD-8 dramatically *reduced* infarct volume and levels of [S100B] protein , a marker of cerebral injury . Negative_regulation S100B MYO10 9788975 541919 We have recently reported that the Ca2+ binding protein [S100beta] was induced in rat heart after infarction and forced expression of S100beta in neonatal rat cardiac myocyte cultures *inhibited* alpha1-adrenergic induction of beta and skeletal alpha-actin ( skACT ) . Negative_regulation S100B MYO16 9788975 541918 We have recently reported that the Ca2+ binding protein [S100beta] was induced in rat heart after infarction and forced expression of S100beta in neonatal rat cardiac myocyte cultures *inhibited* alpha1-adrenergic induction of beta and skeletal alpha-actin ( skACT ) . Negative_regulation S100B MYO19 9788975 541917 We have recently reported that the Ca2+ binding protein [S100beta] was induced in rat heart after infarction and forced expression of S100beta in neonatal rat cardiac myocyte cultures *inhibited* alpha1-adrenergic induction of beta and skeletal alpha-actin ( skACT ) . Negative_regulation S100B MYO6 9788975 541920 We have recently reported that the Ca2+ binding protein [S100beta] was induced in rat heart after infarction and forced expression of S100beta in neonatal rat cardiac myocyte cultures *inhibited* alpha1-adrenergic induction of beta and skeletal alpha-actin ( skACT ) . Negative_regulation S100B OPN1MW 22163000 2517847 *reduced* the expression of [S100B] and iNOS proteins in the human biopsies confirming its well documented effect in septic mice . Negative_regulation S100B PRG2 9796780 543460 Here , it was demonstrated that 5-HT stimulates expression of cartilage core protein , and *inhibits* expression of [S-100beta] and tenascin in mandibular explants . Negative_regulation S100B PRG3 9796780 543461 Here , it was demonstrated that 5-HT stimulates expression of cartilage core protein , and *inhibits* expression of [S-100beta] and tenascin in mandibular explants . Negative_regulation S100B PRG4 9796780 543462 Here , it was demonstrated that 5-HT stimulates expression of cartilage core protein , and *inhibits* expression of [S-100beta] and tenascin in mandibular explants . Negative_regulation S100B SLC25A3 23827043 2808856 *attenuated* the increase of plasma NSE and [S-100B] following CPB . Negative_regulation S100B TLR1 23292665 2887161 [S100B] expression and NO release from EGC , following exposure to bacteria , were measured in the *presence* or absence of specific and S100B pathway inhibitors . Negative_regulation S100B TLR10 23292665 2887169 [S100B] expression and NO release from EGC , following exposure to bacteria , were measured in the *presence* or absence of specific and S100B pathway inhibitors . Negative_regulation S100B TLR2 23292665 2887162 [S100B] expression and NO release from EGC , following exposure to bacteria , were measured in the *presence* or absence of specific and S100B pathway inhibitors . Negative_regulation S100B TLR3 23292665 2887163 [S100B] expression and NO release from EGC , following exposure to bacteria , were measured in the *presence* or absence of specific and S100B pathway inhibitors . Negative_regulation S100B TLR4 23292665 2887164 [S100B] expression and NO release from EGC , following exposure to bacteria , were measured in the *presence* or absence of specific and S100B pathway inhibitors . Negative_regulation S100B TLR5 23292665 2887165 [S100B] expression and NO release from EGC , following exposure to bacteria , were measured in the *presence* or absence of specific and S100B pathway inhibitors . Negative_regulation S100B TLR6 23292665 2887170 [S100B] expression and NO release from EGC , following exposure to bacteria , were measured in the *presence* or absence of specific and S100B pathway inhibitors . Negative_regulation S100B TLR7 23292665 2887166 [S100B] expression and NO release from EGC , following exposure to bacteria , were measured in the *presence* or absence of specific and S100B pathway inhibitors . Negative_regulation S100B TLR8 23292665 2887167 [S100B] expression and NO release from EGC , following exposure to bacteria , were measured in the *presence* or absence of specific and S100B pathway inhibitors . Negative_regulation S100B TLR9 23292665 2887168 [S100B] expression and NO release from EGC , following exposure to bacteria , were measured in the *presence* or absence of specific and S100B pathway inhibitors . Negative_regulation S100B TP53 1454855 205559 Furthermore , and of particular interest , we have shown that purified p53 undergoes temperature dependent oligomerization and that the interaction between [S100b] and p53 not only *induces* total inhibition of oligomerization but also promotes disassembly of the p53 oligomers . Negative_regulation S11 IL1B 9457083 484580 We further show that VEGF blocked *induced* suppression of both TM [surface antigen] and mRNA and was similarly capable of antagonizing the down-regulation of TM by TGF-beta and from cell activation by LPS . Negative_regulation S11 TNF 16797218 1579074 In marked contrast , however , nevertheless *caused* marked down-regulation of the expression of the BMPR-IB [surface antigen] specifically . Negative_regulation S12 IL1B 9457083 484581 We further show that VEGF blocked *induced* suppression of both TM [surface antigen] and mRNA and was similarly capable of antagonizing the down-regulation of TM by TGF-beta and from cell activation by LPS . Negative_regulation S12 TNF 16797218 1579075 In marked contrast , however , nevertheless *caused* marked down-regulation of the expression of the BMPR-IB [surface antigen] specifically . Negative_regulation S1PR1 SPHK1 22098666 2534756 Furthermore , overexpression of increased S1P levels , and the exogenous addition of S1P *increased* liver cell migration and invasion through the [EDG1] receptor . Negative_regulation S1PR3 LPA 15158762 1250732 [S1P(3)] was *induced* during differentiation but down-regulated by lipid loading and HDL ( 3 ) , whereas ( 1 ) was down-regulated in differentiated macrophages . Negative_regulation S1PR3 LPA 18701480 1950419 transactivated the epidermal growth factor receptor (EGFR) in these cells , and the EGFR inhibitor AG1478 *attenuated* the increased SphK1 and [S1P(3)] expression induced by LPA . Negative_regulation S1PR3 RGS2 12564955 1079231 Both RGS1 and RGS3 inhibit signalling through the S1P(1) ( formerly known as EDG-1 ) , S1P(2) ( formerly known as EDG-5 ) and S1P(3) ( formerly known as EDG-3 ) receptors , whereas and RGS4 selectively *attenuate* S1P(2)-and [S1P(3)-receptor] signalling respectively . Negative_regulation S1PR3 RGS4 12564955 1079230 Both RGS1 and RGS3 inhibit signalling through the S1P(1) ( formerly known as EDG-1 ) , S1P(2) ( formerly known as EDG-5 ) and S1P(3) ( formerly known as EDG-3 ) receptors , whereas RGS2 and selectively *attenuate* S1P(2)-and [S1P(3)-receptor] signalling respectively . Negative_regulation S7 IL1B 9457083 484582 We further show that VEGF blocked *induced* suppression of both TM [surface antigen] and mRNA and was similarly capable of antagonizing the down-regulation of TM by TGF-beta and from cell activation by LPS . Negative_regulation S7 TNF 16797218 1579076 In marked contrast , however , nevertheless *caused* marked down-regulation of the expression of the BMPR-IB [surface antigen] specifically . Negative_regulation SAA1 IL1B 9256609 448381 A cytokine IL-6 induced the CRP production in the *presence* of , but did not affect the constitutive production of [SAA] . Negative_regulation SAP130 TNF 7691816 230981 In addition the cytokines interleukin-1 , -6 , and *mediate* a decrease in hepatic [SAP] ( FP ) transcript levels in female hamsters but did not cause a significant elevation of SAP ( FP ) mRNA in livers of male hamsters . Negative_regulation SAP30 TNF 7691816 230978 In addition the cytokines interleukin-1 , -6 , and *mediate* a decrease in hepatic [SAP] ( FP ) transcript levels in female hamsters but did not cause a significant elevation of SAP ( FP ) mRNA in livers of male hamsters . Negative_regulation SCARB1 PDZK1 18544532 1940494 Abolishing expression in PDZK1 knock-out ( KO ) mice *leads* to a post-transcriptional , tissue-specific decrease in [SR-BI] protein level and an increase in total plasma cholesterol carried in abnormally large HDL particles . Negative_regulation SCARB1 PLAU 24529115 2914880 dose-dependently decreased SR-BI protein expression , as determined by flow cytometry ( FACS ) and by Western blot assays , and *down-regulated* [SR-BI] gene expression . Negative_regulation SCARB1 TNF 20212278 2230043 *reduced* both ABCA1 and [SR-BI] expression and impaired cholesterol efflux from partially differentiated adipocytes . Negative_regulation SCGB3A1 IFNG 19135978 2032027 We found that expression of [SCGB3A1] was *down-regulated* by in a time- and dose dependent manner in the murine transformed Clara Cells ( mtCC ) line . Negative_regulation SCIN GSN 11568009 864123 Vector mediated expression of [scinderin] in the megakaryoblastic cell line MEG-01 *induced* a decrease in both F-actin and . Negative_regulation SCIN MUC1 15342343 1353779 [Scinderin] ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* secretion . Negative_regulation SCIN MUC12 15342343 1353780 [Scinderin] ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* secretion . Negative_regulation SCIN MUC13 15342343 1353781 [Scinderin] ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* secretion . Negative_regulation SCIN MUC15 15342343 1353773 [Scinderin] ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* secretion . Negative_regulation SCIN MUC16 15342343 1353774 [Scinderin] ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* secretion . Negative_regulation SCIN MUC17 15342343 1353775 [Scinderin] ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* secretion . Negative_regulation SCIN MUC19 15342343 1353772 [Scinderin] ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* secretion . Negative_regulation SCIN MUC2 15342343 1353782 [Scinderin] ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* secretion . Negative_regulation SCIN MUC20 15342343 1353777 [Scinderin] ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* secretion . Negative_regulation SCIN MUC21 15342343 1353776 [Scinderin] ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* secretion . Negative_regulation SCIN MUC22 15342343 1353778 [Scinderin] ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* secretion . Negative_regulation SCIN MUC4 15342343 1353783 [Scinderin] ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* secretion . Negative_regulation SCIN MUC6 15342343 1353784 [Scinderin] ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* secretion . Negative_regulation SCIN MUC7 15342343 1353785 [Scinderin] ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* secretion . Negative_regulation SCIN MUC8 15342343 1353786 [Scinderin] ( or adseverin ) , a Ca ( 2+ ) -activated actin filament severing and capping protein was cloned from human airway and SPOC1 cells , and synthetic peptides corresponding to its actin binding domains *inhibited* secretion . Negative_regulation SCIN PIP 2162826 135953 This study shows that the activity of [adseverin] is *inhibited* not only by but also by some common phospholipids including phosphatidylinositol ( PI ) and phosphatidylserine ( PS ) . Negative_regulation SCIN SHBG 9452496 484174 Sc5-6 and also *prevented* the actin severing activity of recombinant full-length [scinderin] ( r-Sc ) and inhibited the potentiation by r-Sc of Ca2+ evoked release of serotonin from permeabilized platelets . Negative_regulation SCNN1A EPHB2 11390395 842658 Together , our results demonstrate that mediated induction of HMGI-C is *required* to effectively repress GR/Dex stimulated transcription of [alpha-ENaC] gene and STAT3 mediated transactivation . Negative_regulation SCNN1G IL1B 15063785 1230988 [gamma-ENaC] promoter activity was *inhibited* by and TNFalpha but not by IFNgamma . Negative_regulation SCNN1G TNF 15063785 1230986 [gamma-ENaC] promoter activity was *inhibited* by IL-1beta and but not by IFNgamma . Negative_regulation SCT ARSA 7899465 300094 , but not SA *inhibited* the [secretin-] and CCK stimulated pancreatic secretion including volume , bicarbonate , and protein in a dose dependent manner without affecting basal pancreatic secretion . Negative_regulation SCT ARSA 7899465 300095 The data indicate that *inhibits* both [secretin-] and CCK stimulated pancreatic secretion by a mechanism independent of prostaglandin biosynthesis inhibition . Negative_regulation SCT CCND1 11788592 916932 We show that *represses* BETA2/NeuroD dependent transcription of the [secretin] gene . Negative_regulation SCT MAP2K6 11292597 800868 *inhibits* [secretin] release and pancreatic secretion : roles of secretin releasing peptide and somatostatin . Negative_regulation SCT MAP2K6 11292597 800885 increased plasma SS concentration and *inhibited* [secretin] release and pancreatic fluid and bicarbonate secretion dose-dependently . Negative_regulation SDC1 IL1B 12200971 982968 We also compared the effect of PDGF-BB and TGF-beta 1 , separately and in combination , in the prolonged *presence* of on the expression of both [syndecan] genes . Negative_regulation SDC1 IL1B 12824007 1104356 Stimulation of HT29 cells with TNF-alpha and *resulted* in reversible down-regulation of [syndecan-1] at both protein and mRNA levels but little effect was observed with IL-6 . Negative_regulation SDC1 TNF 12824007 1104355 Stimulation of HT29 cells with and IL-1beta *resulted* in reversible down-regulation of [syndecan-1] at both protein and mRNA levels but little effect was observed with IL-6 . Negative_regulation SDC1 TNF 8702532 375475 None of these factors significantly altered [syndecan-1] mRNA expression in cultured keratinocytes , but when given to endothelial cells , specifically and dose-dependently *suppressed* syndecan-1 expression at both mRNA and protein levels . Negative_regulation SDC1 TNF 8702532 375479 In this tissue *suppressed* [syndecan-1] mRNA expression by approximately 80 % . Negative_regulation SDC2 IL1B 12200971 982969 We also compared the effect of PDGF-BB and TGF-beta 1 , separately and in combination , in the prolonged *presence* of on the expression of both [syndecan] genes . Negative_regulation SDC3 IL1B 12200971 982970 We also compared the effect of PDGF-BB and TGF-beta 1 , separately and in combination , in the prolonged *presence* of on the expression of both [syndecan] genes . Negative_regulation SDC4 IL1B 12200971 982971 We also compared the effect of PDGF-BB and TGF-beta 1 , separately and in combination , in the prolonged *presence* of on the expression of both [syndecan] genes . Negative_regulation SDHAF2 ARSA 3111564 76423 In contrast to LPS-free control cultures , did not completely *prevent* [PGl2] formation by human endothelial cells after exposure to LPS suggesting the induction of a cyclooxygenase independent pathway by LPS . Negative_regulation SDS PLAT 9364046 462974 In vitro , neuroserpin formed [SDS-stable] complexes and *inhibited* the amidolytic activity of , urokinase , and plasmin . Negative_regulation SEA FAS 12373453 996541 When Fas-deficient ( C57BL/6 lpr/lpr ) or Fas ligand defective ( C57BL/6 gld/gld ) mice were treated with TCDD , they failed to exhibit a decrease in percentage and cellularity of SEA-reactive T cells , thereby suggesting a *role* of ligand interactions in the TCDD induced downregulation of [SEA-reactive] T cell response . Negative_regulation SELE LY6D 10777581 686874 The GPI linked Ly-6 antigen *regulates* expression levels of the FX enzyme and of [E-selectin] ligands on head and neck squamous carcinoma cells . Negative_regulation SELE PCSK9 17996668 1821719 Further study demonstrated that the mRNA expression of tumor necrosis factor-alpha and adhesion molecules , such as vascular cell adhesion molecule-1 , intercellular adhesion molecule-1 , [E-selectin] , was also *suppressed* by in the ear of mite extract treated NC/Nga mice . Negative_regulation SELE SRGN 19271170 2045709 ( 1-5 mmol/L ) *inhibited* the VEC surface expression of [CD62E] and CD54 in a dose dependent way ( ( 1-5 mmol/L ) inhibited the VEC surface expression of CD62E and CD54 in a dose dependent way ( P < 0.05 ) . Negative_regulation SELE TNF 10030794 591781 *Role* of and interferon gamma in endotoxin induced [E-selectin] expression . Negative_regulation SELE TNF 10964678 727871 Peroxisome proliferator activated receptor ( PPAR ) activators were shown to inhibit the expression of [E-selectin] of human vascular endothelial cells in *response* to . Negative_regulation SELE TNF 11888521 920047 Inhibition of *induced* ICAM-1 , VCAM-1 and [E-selectin] expression by selenium . Negative_regulation SELE TNF 12438297 1016540 Stimulation of the Ad.null infected endothelial cells with *resulted* in enhanced expression of endothelial intracellular adhesion molecule-1 , vascular cellular adhesion molecule-1 , and [E-selectin] and enhanced adhesion of monocytic U937 cells to the HAECs . Negative_regulation SELE TNF 12514595 1039165 Fluid flow inhibited [E-selectin] protein levels by about 50 % in *response* to but had no effect on total E-selectin messenger RNA ( mRNA ) expression . Negative_regulation SELE TNF 12527821 1028287 On TNFalpha activated HUVECs , NAAGA induced a significant decrease in the VCAM-1 expression level ( P < 0.0001 ) and totally reversed *induced* overexpression of ICAM-1 ( P=0.0069 ) , ICAM-2 and [ELAM-1] ( P < 0.0001 ) , without interfering with baseline expression of these molecules . Negative_regulation SELE TNF 12919942 1157683 activation of HEMEC *resulted* in upregulation of the cell adhesion molecules (CAM) ICAM-1 , VCAM-1 , [E-selectin] , and mucosal addressin CAM-1 (MAdCAM-1) , increased IL-8 production , and enhanced leukocyte binding . Negative_regulation SELE TNF 12951474 1137348 DMSO did not affect expression of [E-selectin] on endothelial cells in the *presence* of . Negative_regulation SELE TNF 14629460 1170405 Furthermore , GGTI-286 , but not FTI-277 , mimicked the effect of simvastatin by increasing the *mediated* overexpression of [E-selectin] . Negative_regulation SELE TNF 19878508 2293558 The objectives of this study were to : ( 1 ) determine the body composition , metabolic and inflammatory factors associated with increased E-selectin and ( 2 ) determine the *role* of in the physiological regulation of [E-selectin] by antagonism of TNF-alpha with etanercept among obese subjects . Negative_regulation SELE TNF 7578984 333392 The current study was undertaken to investigate the *role* of in regulation of [E-selectin] and ICAM-1 expression by TNF on HUVEC . Negative_regulation SELE TNF 7691889 231026 In a distinct pattern , PDTC partially inhibited [E-selectin] gene expression in *response* to but not to LPS , IL-1 beta , or PIC . Negative_regulation SELE TNF 8386742 217836 This finding correlated with the exclusive activity of TNF-R55 in the *dependent* regulation of the expression of the intercellular adhesion molecule type 1 ( ICAM-1 ) , [E-selectin] , and vascular cell adhesion molecule type 1 ( VCAM-1 ) . Negative_regulation SELE TNF 8596155 342148 PUVA led to significant dose dependent decreases in the expression of VCAM-1 and [E-selectin] that had been *induced* with before PUVA treatment . Negative_regulation SELE TNF 9039934 415823 Soluble alpha receptor *inhibited* [E-selectin] induced by TNF alpha , but not by U937 cells , and mRNA and protein on EC in Mo-EC mixtures cocultured at 1 : 1 ratios were not significantly reduced . Negative_regulation SELE TNF 9728048 530018 These findings indicate that induces NF-kappaB activation and the resultant E-selectin gene expression by a pathway that involves formation of ROS and that [E-selectin] expression can be *inhibited* by the antioxidant action of NAC or PDTC . Negative_regulation SELE TNF 9751850 533694 HNMEC differed from human umbilical vein endothelila cells in that ( 1 ) maximal upregulation of ICAM-1 expression induced by IL-1beta or TNF-alpha required more time ( 2 ) was more potent than IL-1beta in VCAM-1 expression , and ( 3 ) dexamethasone *inhibited* the upregulation of [E-selectin] expression alone . Negative_regulation SELL ABL1 21277237 2398196 *Role* of in [L-selectin] shedding from the neutrophil surface . Negative_regulation SELL ADAM17 16735599 1612375 In addition , the absence of functional *resulted* in significantly increased levels of [L-selectin] surface expression by peripheral-blood leukocytes , indicating the sheddase also plays a role in the constitutive cleavage of L-selectin . Negative_regulation SELL ADO 1374393 186296 Northern analysis demonstrated that significantly *reduced* thrombin- and PMA stimulated steady-state levels of PDGF-A chain , PDGF-B chain , and [endothelial-leukocyte adhesion molecule-1] ( ELAM-1 ) mRNAs . Negative_regulation SELL AGO2 15137490 1246138 Likewise , M. bovis stimulation of lymphocytes from vaccinated deer *resulted* in increases in CD44 expression and decreases in [CD62L] expression . Negative_regulation SELL AHR 18382861 1892986 When CD4+ and CD8+ donor T-cells from AhR-WT and AhR-KO mice were injected in various combinations into F1 mice , the enhanced expression of CD25 on CD8+ T-cells required AhR in donor CD4+ T-cells , while down-regulation of [CD62L] *required* in the donor CD8+ T-cells themselves . Negative_regulation SELL AHR 19635034 2118535 Expression of constitutively-active in T-cells *enhances* the down-regulation of [CD62L] , but does not alter expression of CD25 or suppress the allogeneic CTL response . Negative_regulation SELL AHR 19635034 2118536 Expression of in donor T-cells *enhanced* the down-regulation of [CD62L] on Day 2 after injection , similar to a single oral dose of TCDD , but did not induce up-regulation of CD25 on Day 2 or affect CTL activity on Day 10 . Negative_regulation SELL AMPH 23644142 2795805 In OVA sensitized and challenged mice , and MK-801 given alone decreased cellular migration into the lung , reduced IL-13 and IL10 levels in BAL supernatant , *reduced* ICAM-1 and [L-selectin] expression in granulocytes in the BAL and decreased mast cell degranulation . Negative_regulation SELL ANGPT2 19837408 2224672 We report for the first time that *down-regulated* [CD62L] from the surface of human neutrophils , a process which was independent of neutrophil adhesion to endothelium since neutrophils were still able to adhere to human umbilical vein endothelial cells even under doses that almost completely release CD62L from the cell surface . Negative_regulation SELL ANXA1 11342653 813847 We show that *induces* a dose- and time dependent decrease in [L-selectin] expression on both peripheral blood neutrophils and monocytes but has no effect on lymphocytes . Negative_regulation SELL ARG1 10769287 685464 The relaxing effect of des-Arg ( 9 ) -bradykinin on isolated coronary rings was *prevented* by ( 9 ) , [ [Leu(8)] ] -bradykinin . Negative_regulation SELL ARG2 10769287 685465 The relaxing effect of des-Arg ( 9 ) -bradykinin on isolated coronary rings was *prevented* by ( 9 ) , [ [Leu(8)] ] -bradykinin . Negative_regulation SELL BLM 17886030 1797400 The *induced* down-regulation of [L-selectin] expression on circulating neutrophils was inhibited by rhTRX . Negative_regulation SELL CA2 8600168 351821 However , ATP induced loss of [L-selectin] did not *require* extracellular . Negative_regulation SELL CALM3 10677354 668103 Prevention of interaction by CaM inhibitors or mutation of a CaM binding site in L-selectin *induced* [L-selectin] ectodomain shedding . Negative_regulation SELL CD28 11589827 869270 Our results also demonstrate that whereas the transduction procedure per se did not significantly alter the expression of lymphocyte homing receptors , anti-CD3 and antibody stimulation profoundly *reduced* the expression of [L-selectin] . Negative_regulation SELL CD4 10449768 637398 Here , we show that ligation of , without ligation of the T cell receptor for antigen , *causes* down-regulation of [L-selectin] on T helper cells . Negative_regulation SELL CD69 21904217 2478243 Expression of , a transmembrane protein that plays a critical role in lymphocyte egress from tissues and the chemokine receptor CXCR4 , increased on thawed populations and levels of [CD62L] and CXCR3 were *reduced* on thawed cells but restored if cells were allowed to recover after thawing . Negative_regulation SELL CDC73 7686761 222301 also *caused* a decrease in [L-selectin] expression in eosinophils ( -37.0 +/- 8.1 % , P < 0.001 ) and neutrophils ( -14.1 +/- 3.2 % , P < 0.05 ) . Negative_regulation SELL CDC73 9335316 457994 up-regulated the expression of CDllb/CD18 , *down-regulated* [L-selectin] , and also increased F-actin assembly in eosinophils . Negative_regulation SELL CSF2 10037043 591998 in vitro incubation with SCF or IL-3 enhanced the expression of CD49d on CD34+ cells , while *reduced* the expression of [CD62L] . Negative_regulation SELL CSF2 1372261 182946 In contrast , IL 3 , IL 4 , granulocyte-macrophage ( GM-CSF ) and lipopolysaccharide (LPS) *prevented* the induction of [L-selectin] in a time- and dose dependent manner . Negative_regulation SELL CSF2 1372261 182949 Furthermore , [L-selectin] was *down-regulated* on cultured unselected bone marrow cells by IL 3 , IL 4 , and LPS stimulation . Negative_regulation SELL CSF2 7692935 231197 *down-regulated* neutrophil [LAM-1] expression in a time- and dose dependent manner . Negative_regulation SELL CSF3 8757506 374704 , like GM-CSF , increased surface levels of the adhesive receptor , CD11b/CD18 , but *down-regulated* [L-selectin] expression on neutrophils . Negative_regulation SELL CSRP1 11673552 872864 Both and mCRP ( 0.1-200 microg/ml ) *down-regulated* neutrophil [L-selectin] expression in a concentration dependent fashion . Negative_regulation SELL CSRP1 9239398 445871 Neutrophil attachment and [L-selectin] expression were also *diminished* by peptides 174-185 and 201-206 , but not peptide 77-82 , albeit these peptides showed a weaker inhibitory effect than the parent protein . Negative_regulation SELL CTR9 7686761 222302 also *caused* a decrease in [L-selectin] expression in eosinophils ( -37.0 +/- 8.1 % , P < 0.001 ) and neutrophils ( -14.1 +/- 3.2 % , P < 0.05 ) . Negative_regulation SELL CTR9 9335316 457995 up-regulated the expression of CDllb/CD18 , *down-regulated* [L-selectin] , and also increased F-actin assembly in eosinophils . Negative_regulation SELL EDN1 11877323 919036 2 . rapidly *down-regulated* the expression of [L-selectin] and up-regulated the expression of CD11b/CD18 on the neutrophil surface . Negative_regulation SELL FCGR3A 8609224 352763 In the absence of serum , galactoxylomannan and mannoprotein did not affect L-selectin , TNF receptor , CD15 , CD11b , or on neutrophils but did *induce* loss of [L-selectin] in the presence of serum . Negative_regulation SELL FOXO1 20831893 2346457 We found that IL-7 prevented the nuclear translocation of the transcription factor , , in a manner dependent on the activity of Cdc25A , resulting in decreased *levels* of [CD62L] . Negative_regulation SELL HNRNPF 12963696 1138646 While were also *required* for an efficient down-regulation of [CD62L] , this function was not restricted to MLN DCs . Negative_regulation SELL HNRNPF 20726990 2318012 However , CTCs reduce significantly the ability of to *stimulate* interferon-? production and the loss of [CD62L] by T cells . Negative_regulation SELL HNRNPH1 12963696 1138647 While were also *required* for an efficient down-regulation of [CD62L] , this function was not restricted to MLN DCs . Negative_regulation SELL HNRNPH1 20726990 2318013 However , CTCs reduce significantly the ability of to *stimulate* interferon-? production and the loss of [CD62L] by T cells . Negative_regulation SELL HPX 20971829 2407130 Moreover , inhibited the neutrophil chemotaxis response evoked by C5a or macrophage inflammatory protein-2 and *induced* a reduction of CXCR2 and [L-selectin] as well as the up-regulation of CD11b expression in neutrophil membranes . Negative_regulation SELL IL10 8582548 341211 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL11 8582548 341212 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL13 8582548 341213 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL15 8582548 341214 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL15 9647249 514972 NK activation by PMA , IL-2 , , or TGF-beta *down-regulated* [L-selectin] on the CD56bright subset , while increased L-selectin levels were observed in both the CD56bright and CD56dim NK subsets in response to IL-12 , IL-10 , or IFN-alpha . Negative_regulation SELL IL16 8582548 341215 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL18 8582548 341216 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL19 8582548 341217 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL2 7678616 209945 Differential regulation of L-selectin can also be demonstrated in vitro by the activation of virgin T cells in the presence of specific cytokines -- *induces* [L-selectin] down-regulation , whereas IL-6 and particularly TGF-beta 1 promote L-selectin up-regulation . Negative_regulation SELL IL2 8582548 341218 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL20 8582548 341219 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL21 8582548 341220 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL22 8582548 341203 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL24 8582548 341201 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL25 16792588 1578774 Our findings suggest an essential *role* of in enhancing survival and regulating surface expression of ICAM-1 , ICAM-3 and [L-selectin] on human eosinophils through the activation of p38 MAPK , JNK and nuclear factor (NF)-kappaB pathways , thereby shedding light on the molecular mechanisms of IL-25 induced eosinophilia in allergic inflammation . Negative_regulation SELL IL25 8582548 341202 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL26 8582548 341207 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL27 8582548 341208 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL2RA 19635034 2118537 Expression of CA-AhR in donor T-cells enhanced the down-regulation of [CD62L] on Day 2 after injection , similar to a single oral dose of TCDD , but did not *induce* up-regulation of on Day 2 or affect CTL activity on Day 10 . Negative_regulation SELL IL3 1372261 182947 In contrast , , IL 4 , granulocyte-macrophage colony stimulating factor ( GM-CSF ) and lipopolysaccharide (LPS) *prevented* the induction of [L-selectin] in a time- and dose dependent manner . Negative_regulation SELL IL3 1372261 182950 Furthermore , [L-selectin] was *down-regulated* on cultured unselected bone marrow cells by , IL 4 , GM-CSF and LPS stimulation . Negative_regulation SELL IL3 8582548 341221 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL31 8582548 341209 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL32 8582548 341206 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL33 8582548 341205 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL34 8582548 341210 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL37 8582548 341204 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL3RA 17056507 1636562 Cross linking of , but not the other receptors , *caused* the up-regulation of costimulatory molecules CD80 and CD86 , as well as the down-regulation of [CD62L] , indicating PDC maturation . Negative_regulation SELL IL4 1372261 182948 In contrast , IL 3 , , granulocyte-macrophage colony stimulating factor ( GM-CSF ) and lipopolysaccharide (LPS) *prevented* the induction of [L-selectin] in a time- and dose dependent manner . Negative_regulation SELL IL4 8582548 341222 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL5 7686761 222306 also *caused* a 49.5 +/- 4.2 % decrease in eosinophil [L-selectin] expression ( P < 0.001 ) but had no effect on L-selectin expression in neutrophils . Negative_regulation SELL IL5 8582548 341223 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL6 12181114 977439 Recombinant human ( 2 microg/kg ) *caused* a decrease in [L-selectin] levels on circulating PMN 3 to 12 h after treatment ( P < 0.05 ) . Negative_regulation SELL IL6 8582548 341224 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL7 20831893 2346458 We found that prevented the nuclear translocation of the transcription factor , Foxo1 , in a manner dependent on the activity of Cdc25A , resulting in decreased *levels* of [CD62L] . Negative_regulation SELL IL7 8582548 341225 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL8 10095863 560671 Moreover , EM downregulated [L-selectin] expression and *inhibited* induced upregulation of Mac-1 on peripheral blood neutrophils . Negative_regulation SELL IL8 7806065 292509 Infected Kato III supernatants activated neutrophils as evidenced by increased CD11b/CD18 and decreased [L-selectin] that could be *blocked* by . Negative_regulation SELL IL8 8582548 341226 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL IL9 8582548 341227 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Negative_regulation SELL ITGAM 8609224 352764 In the absence of serum , galactoxylomannan and mannoprotein did not affect L-selectin , TNF receptor , CD15 , , or CD16 on neutrophils but did *induce* loss of [L-selectin] in the presence of serum . Negative_regulation SELL ITGAM 8707129 376339 The basal expression of [L-selectin] , CD11a , and CD15 was significantly decreased in jaundiced patients ( p < 0.05 ) and the expression of in response to stimulation with fMLP and endotoxin was significantly *impaired* in the jaundiced group . Negative_regulation SELL ITGB2 10095863 560672 Moreover , EM downregulated [L-selectin] expression and *inhibited* interleukin (IL)-8 induced upregulation of on peripheral blood neutrophils . Negative_regulation SELL ITGB2 17382451 1766051 While the upregulation of expression is inhibited in a dose dependent manner , the expression of [L-selectin] is *enhanced* at low concentrations of dobutamine and dopexamine and partly counter regulated at high concentrations . Negative_regulation SELL KLF2 21187410 2378892 We report that B cell-specific deficiency *leads* to decreased expression of the trafficking molecules [CD62L] and ß7-integrin , yet expression of sphingosine-1 phosphate receptor 1 ( which is a critical target of KLF2 in T cells ) was , unexpectedly , minimally altered . Negative_regulation SELL LCK 18653462 1967072 Critical *role* of in [L-selectin] signaling induced by sulfatides engagement . Negative_regulation SELL LEO1 7686761 222305 also *caused* a decrease in [L-selectin] expression in eosinophils ( -37.0 +/- 8.1 % , P < 0.001 ) and neutrophils ( -14.1 +/- 3.2 % , P < 0.05 ) . Negative_regulation SELL LEO1 9335316 457998 up-regulated the expression of CDllb/CD18 , *down-regulated* [L-selectin] , and also increased F-actin assembly in eosinophils . Negative_regulation SELL LEP 17634954 1775343 could up-regulate cell surface expression of adhesion molecule ICAM-1 and CD18 but *suppress* ICAM-3 and [L-selectin] on eosinophils . Negative_regulation SELL LTF 10708745 673602 *inhibits* the binding of lipopolysaccharides to [L-selectin] and subsequent production of reactive oxygen species by neutrophils . Negative_regulation SELL NOX1 23142710 2722821 Interestingly , diclofenac and flufenamic acid but not piroxicam significantly increased the extracellular superoxide anion production by neutrophils , and inhibition of nicotinamide adenine dinucleotide phosphate ( activity with diphenyleneiodonium *prevented* the down-regulation of [L-selectin] by diclofenac . Negative_regulation SELL NOX3 23142710 2722822 Interestingly , diclofenac and flufenamic acid but not piroxicam significantly increased the extracellular superoxide anion production by neutrophils , and inhibition of nicotinamide adenine dinucleotide phosphate ( activity with diphenyleneiodonium *prevented* the down-regulation of [L-selectin] by diclofenac . Negative_regulation SELL NOX4 23142710 2722823 Interestingly , diclofenac and flufenamic acid but not piroxicam significantly increased the extracellular superoxide anion production by neutrophils , and inhibition of nicotinamide adenine dinucleotide phosphate ( activity with diphenyleneiodonium *prevented* the down-regulation of [L-selectin] by diclofenac . Negative_regulation SELL NOX5 23142710 2722820 Interestingly , diclofenac and flufenamic acid but not piroxicam significantly increased the extracellular superoxide anion production by neutrophils , and inhibition of nicotinamide adenine dinucleotide phosphate ( activity with diphenyleneiodonium *prevented* the down-regulation of [L-selectin] by diclofenac . Negative_regulation SELL NR3C1 14761937 1235094 Our results indicate that glucocorticoid induced suppression of [L-selectin] , which accompanies neutrophilia , is likely *mediated* by direct effects of activation on intracellular reservoirs of L-selectin mRNA and protein in cattle , predominantly in blood neutrophils . Negative_regulation SELL P2RX7 23319734 2738320 Mitochondrial superoxide generation enhances *mediated* loss of cell surface [CD62L] on naive human CD4+ T lymphocytes . Negative_regulation SELL PAF1 7686761 222303 also *caused* a decrease in [L-selectin] expression in eosinophils ( -37.0 +/- 8.1 % , P < 0.001 ) and neutrophils ( -14.1 +/- 3.2 % , P < 0.05 ) . Negative_regulation SELL PAF1 9335316 457996 up-regulated the expression of CDllb/CD18 , *down-regulated* [L-selectin] , and also increased F-actin assembly in eosinophils . Negative_regulation SELL PTBP1 12963696 1138648 While were also *required* for an efficient down-regulation of [CD62L] , this function was not restricted to MLN DCs . Negative_regulation SELL PTBP1 20726990 2318014 However , CTCs reduce significantly the ability of to *stimulate* interferon-? production and the loss of [CD62L] by T cells . Negative_regulation SELL PTBP2 12963696 1138645 While were also *required* for an efficient down-regulation of [CD62L] , this function was not restricted to MLN DCs . Negative_regulation SELL PTBP2 20726990 2318011 However , CTCs reduce significantly the ability of to *stimulate* interferon-? production and the loss of [CD62L] by T cells . Negative_regulation SELL PTPRC 8693290 372835 engagement *induces* [L-selectin] down-regulation . Negative_regulation SELL PTPRC 8693290 372838 The MoAbs IOL1b , AICD45.2 and GAP8.3 recognized granulocyte expressed but did not *induce* loss of [L-selectin] expression of granulocytes . Negative_regulation SELL PTX3 24387024 903800 *induced* the down-regulation of [L-selectin] expression in dose- and time dependent manner . Negative_regulation SELL PTX4 24387024 903799 *induced* the down-regulation of [L-selectin] expression in dose- and time dependent manner . Negative_regulation SELL RASA1 8693290 372839 The MoAbs IOL1b , AICD45.2 and recognized granulocyte expressed CD45 but did not *induce* loss of [L-selectin] expression of granulocytes . Negative_regulation SELL SEA 9716103 527833 Stimulation of PBM with also *resulted* in increased levels of soluble and [L-selectin] in the cell supernatants . Negative_regulation SELL TCF12 20831893 2346446 We found that IL-7 prevented the nuclear translocation of the , Foxo1 , in a manner dependent on the activity of Cdc25A , resulting in decreased *levels* of [CD62L] . Negative_regulation SELL TCF15 20831893 2346447 We found that IL-7 prevented the nuclear translocation of the , Foxo1 , in a manner dependent on the activity of Cdc25A , resulting in decreased *levels* of [CD62L] . Negative_regulation SELL TCF19 20831893 2346448 We found that IL-7 prevented the nuclear translocation of the , Foxo1 , in a manner dependent on the activity of Cdc25A , resulting in decreased *levels* of [CD62L] . Negative_regulation SELL TCF20 20831893 2346449 We found that IL-7 prevented the nuclear translocation of the , Foxo1 , in a manner dependent on the activity of Cdc25A , resulting in decreased *levels* of [CD62L] . Negative_regulation SELL TCF21 20831893 2346450 We found that IL-7 prevented the nuclear translocation of the , Foxo1 , in a manner dependent on the activity of Cdc25A , resulting in decreased *levels* of [CD62L] . Negative_regulation SELL TCF23 20831893 2346454 We found that IL-7 prevented the nuclear translocation of the , Foxo1 , in a manner dependent on the activity of Cdc25A , resulting in decreased *levels* of [CD62L] . Negative_regulation SELL TCF24 20831893 2346456 We found that IL-7 prevented the nuclear translocation of the , Foxo1 , in a manner dependent on the activity of Cdc25A , resulting in decreased *levels* of [CD62L] . Negative_regulation SELL TCF25 20831893 2346455 We found that IL-7 prevented the nuclear translocation of the , Foxo1 , in a manner dependent on the activity of Cdc25A , resulting in decreased *levels* of [CD62L] . Negative_regulation SELL TCF3 20831893 2346451 We found that IL-7 prevented the nuclear translocation of the , Foxo1 , in a manner dependent on the activity of Cdc25A , resulting in decreased *levels* of [CD62L] . Negative_regulation SELL TCF4 20831893 2346452 We found that IL-7 prevented the nuclear translocation of the , Foxo1 , in a manner dependent on the activity of Cdc25A , resulting in decreased *levels* of [CD62L] . Negative_regulation SELL TCF7 20831893 2346453 We found that IL-7 prevented the nuclear translocation of the , Foxo1 , in a manner dependent on the activity of Cdc25A , resulting in decreased *levels* of [CD62L] . Negative_regulation SELL TGFB1 7678616 209944 Differential regulation of L-selectin can also be demonstrated in vitro by the activation of virgin T cells in the presence of specific cytokines -- IL-2 induces [L-selectin] down-regulation , whereas IL-6 and particularly *promote* L-selectin up-regulation . Negative_regulation SELL TNF 21237580 2397721 Stimulation with *resulted* in a significant decrease of [L-selectin] expression at 0 h ( 25.6±2.7 ng/ml ; p < 0.05 ) and 24 h ( 18.3±2.5 ng/ml ; p < 0.05 ) , but not at 48 h ( 39.8±4.2 ng/ml ) . Negative_regulation SELL TNF 8609224 352762 In the absence of serum , galactoxylomannan and mannoprotein did not affect L-selectin , receptor , CD15 , CD11b , or CD16 on neutrophils but did *induce* loss of [L-selectin] in the presence of serum . Negative_regulation SELL WDR61 7686761 222304 also *caused* a decrease in [L-selectin] expression in eosinophils ( -37.0 +/- 8.1 % , P < 0.001 ) and neutrophils ( -14.1 +/- 3.2 % , P < 0.05 ) . Negative_regulation SELL WDR61 9335316 457997 up-regulated the expression of CDllb/CD18 , *down-regulated* [L-selectin] , and also increased F-actin assembly in eosinophils . Negative_regulation SELP ARSA 18413191 2010288 In vitro , significantly *inhibited* both GPIIb-IIIa expression ( 36.5 % ) and [P-selectin] expression ( 81 % ; Negative_regulation SELP F2R 12632022 1067920 In summary , Ca(II)3 ( 3,5-DIPS ) 6 , a new calmodulin dependent nitric oxide synthase activator , decreases [P-selectin] expression of human platelets in *response* to activation . Negative_regulation SELP F2R 14597986 1161014 decreased by approximately 8 % ( p < 0.001 ) within 2 h after endotoxin infusion and stayed at those levels until 6 h. Concomitantly , TRAP *induced* [P-selectin] expression maximally decreased by 18 % ( p < 0.001 ) at 6 h . Negative_regulation SELP F2R 20180904 2272418 These results suggest a physiologic role for the low concentration of thrombin in maintaining the integrity of the EPCR containing vasculature through the *dependent* inhibition of Ang2 and [P-selectin] release from Weibel-Palade bodies . Negative_regulation SELP HES2 16987338 1617824 HES200/0.5 and *reduced* the CD42b , CD41/61 and [CD62p] expression of ADP-agonist activated platelets at 15 min after intravenous infusion . Negative_regulation SELP MMP28 22566571 2619190 The reduced [P-selectin] and PSGL-1 density , on SHR postcapillary endothelium and on SHR leukocytes , respectively , was *restored* significantly by chronic inhibition . Negative_regulation SELP MMP7 22566571 2619205 The reduced [P-selectin] and PSGL-1 density , on SHR postcapillary endothelium and on SHR leukocytes , respectively , was *restored* significantly by chronic inhibition . Negative_regulation SELP PECAM1 24969778 2952458 Here , we show that the activation of *inhibits* fibrinogen binding to integrin aIIbß3 and [P-selectin] surface expression in response to thrombin ( 0.1-3 U/mL ) but not thrombin receptor activating peptides SFLLRN ( 3×10 ( -7 ) -1×10 ( -5 ) mol/L ) and GYPGQV ( 3×10 ( -6 ) -1×10 ( -4 ) mol/L ) . Negative_regulation SELP PLAT 12913399 1030978 and abciximab/rPA *caused* decreases in platelet-leukocyte aggregates as well as in binding of specific antibodies to the platelet vitronectin receptor and [P-selectin] ( p < 0.05 , respect. ) . Negative_regulation SELP PLAT 8968338 402665 Immunohistochemical localization of [P-selectin] in the ischemic region was also significantly *reduced* by S-nitrosylated , compared with the control group ( P < .01 ) . Negative_regulation SELP PLAT 9489975 489322 Although the effect of acetylsalicylic acid at 160 mg/day on P-selectin expression was minimal , a dose of 660 mg/day suppressed platelet [P-selectin] expression and *inhibited* the platelet activating effects of and urokinase in a statistically significant way . Negative_regulation SELP SELL 19056851 2017734 Selective disruption of ligand production did not *reduce* atherosclerosis as robustly as disruption of E- and [P-selectin] ligands . Negative_regulation SEMA3C ADAMTS1 19915008 2189955 Both techniques showed that overexpression of *leads* to the release of [semaphorin 3C] from the extracellular matrix . Negative_regulation SEMA4D EPHB2 19444311 2090601 M-Ras ( Q71L ) stimulated extracellular signal regulated kinase ( ERK ) activation , inducing dendrite growth , whereas [Sema4D] suppressed ERK activity and down-regulation of was *required* for a Sema4D induced reduction of dendrite growth . Negative_regulation SEPP1 TNF 12878326 1115569 In this study , we investigated the molecular mechanisms by which HBx *induced* lipid peroxidation and expression through regulation of [selenoprotein P (SeP)] expression in the human hepatoma cell line , HepG2 . Negative_regulation SERPINA4 FOXO1 20081110 2212548 Pivotal *role* of JNK dependent activation in downregulation of [kallistatin] expression by oxidative stress . Negative_regulation SERPINB2 IL1B 10743860 680563 Our previous studies had demonstrated that in inflamed gingival tissues , tissue-type plasminogen activator (t-PA) is significantly increased in the extracellular matrix of the connective tissue and that can up *regulate* the level of t-PA and [plasminogen activator inhibitor-2] ( PAI-2 ) synthesis by human gingival fibroblasts . Negative_regulation SERPINB2 MAP2K6 20494554 2276331 The calcium induced PAI-2 expression was abolished by treatment with p38 MAPK inhibitor , while overexpression of *led* to the increase of [PAI-2] expression . Negative_regulation SERPINB2 PLAU 11063652 746777 The aim of this study was to determine the level of mRNA expression for the genes encoding urokinase ( ) , urokinase receptor ( uPAR ) , and plasminogen activator *inhibitor* ( [PAI-2] ) in endometrial carcinomas . Negative_regulation SERPINB2 PLAU 7556451 327677 Differential expression of urokinase-type plasminogen activator ( ) , its receptor ( uPA-R ) , and *inhibitor* type-2 ( [PAI-2] ) during differentiation of keratinocytes in an organotypic coculture system . Negative_regulation SERPINB2 PLAU 8388810 220269 Complexes between the urokinase-type plasminogen activator ( ) and its type-2 *inhibitor* ( [PAI-2] ) are bound by a cell-surface receptor for uPA and rapidly cleaved into two fragments of 70 and 22 kDa . Negative_regulation SERPINB2 TNF 8898893 393156 However , treatment of cells with TNF results in a profound selective reduction in site-B binding activity , suggesting that this site plays a significant role in *mediated* regulation of [PAI-2] gene expression . Negative_regulation SERPINB3 CLDN10 24114540 2863672 Downregulation of by siRNA *resulted* in the decrease of [SCC] and PD , but not TER , in B4G12 cells . Negative_regulation SERPINB3 IL1B 21912958 2524869 In the present study , we examined the potential *role* and prognostic value of in esophageal [squamous cell carcinoma (SCC)] . Negative_regulation SERPINB3 MMP28 18284387 1885325 The *role* of in RDEB associated [SCC] is not known . Negative_regulation SERPINB3 MMP7 18284387 1885340 The *role* of in RDEB associated [SCC] is not known . Negative_regulation SERPINB5 TNF 21856005 2501028 signaling *triggers* the nuclear accumulation of RelB and the concomitant reduction of [Maspin] expression in a time dependent manner . Negative_regulation SERPINC1 F3 2632043 124996 It is known that [antithrombin III (ATIII)] activity is *inhibited* by tissue in the presence of heparin . Negative_regulation SERPINC1 TNF 21962807 2507338 [At 3] and 6 h , the increased and IL-1ß levels in plasma and MPO activity in lung tissue by LPS could be significantly *inhibited* by fasudil . Negative_regulation SERPINC1 TNF 24726586 2935750 After I/R , AST and ALT were significantly elevated , [ATIII] levels were significantly depleted , both and ICAM-1 levels *increased* and ET-1 was significantly elevated ( at 180 min ) . Negative_regulation SERPINE1 ANGPT1 11031218 740180 In vitro , , Ang II , and angiotensin Arg(2)-Phe ( 8 ) ( Ang III ) were potent agonists of PAI-1 mRNA expression in rat aortic smooth muscle cells ( RASMCs ) , and stimulation of [PAI-1] by these peptides was *blocked* by the AT(1) antagonist candesartan . Negative_regulation SERPINE1 ARSA 2371491 138364 The [PAI-1] release from platelets stimulated by arachidonic acid and collagen was significantly *reduced* by : from average values of 88 and 80 % to 14 and 17 % , respectively ( p less than 0.01 ) . Negative_regulation SERPINE1 EPHB2 12595493 1061586 *inhibited* MCP-1 and [PAI-1] mRNA expression in MC , but not TGF-beta1 . Negative_regulation SERPINE1 EPHB2 17264880 1691415 Inhibiting and JNK pathways significantly *reduced* [PAI] and uPA induction and inhibited the invasive cell phenotype . Negative_regulation SERPINE1 EPHB2 17379280 1815507 Inhibitors of or JNK *prevented* polyphenol repression of EC [PAI-1] gene expression . Negative_regulation SERPINE1 EPHB2 24500480 2914033 Pg LPS also induced , p38 , and JNK activation , and Pg LPS induced [PAI-1] expression was *inhibited* by ERK/p38/JNK inhibitor pretreatment . Negative_regulation SERPINE1 FOXO1 19563779 2110777 Here , we examined whether adenoviral mediated expression of a constitutively active form of ( Ad-CA-FoxO1 ) *inhibited* insulin stimulated [PAI-1] expression in human HepG2 hepatocellular liver carcinoma cells and mouse AML12 hepatocytes . Negative_regulation SERPINE1 FOXO1 19563779 2110779 Transient transfection assays using a reporter gene under the control of the PAI-1 promoter revealed that *inhibits* Smad3 stimulated [PAI-1] promoter activity . Negative_regulation SERPINE1 FOXO1 19563779 2110781 Taken together , our results indicate that *inhibits* [PAI-1] expression through the inhibition of TGF-beta/Smad mediated signaling pathways . Negative_regulation SERPINE1 GPR115 15808835 1391355 Role of c-Jun NH2-terminal kinase in agonist *induced* cardiac [plasminogen activator inhibitor-1] expression . Negative_regulation SERPINE1 GPR132 15808835 1391344 Role of c-Jun NH2-terminal kinase in agonist *induced* cardiac [plasminogen activator inhibitor-1] expression . Negative_regulation SERPINE1 GPR87 15808835 1391424 Role of c-Jun NH2-terminal kinase in agonist *induced* cardiac [plasminogen activator inhibitor-1] expression . Negative_regulation SERPINE1 IL1B 19490965 2149460 Additionally , IL-1beta stimulated both HIF-1alpha and [PAI-1] in articular chondrocytes , and the mediated induction of PAI-1 was *inhibited* partly by HIF-1alpha silencing . Negative_regulation SERPINE1 NEDD9 11489354 845297 We verified the regulation of protooncogene cot , XMP , and human ( HEF1 ) , genes involved in cellular proliferation , as well as metallothionein , plasminogen activator *inhibitor* ( [PAI1] ) , and HM74 , genes involved in cellular signaling and regeneration . Negative_regulation SERPINE1 PLAT 12637546 1085426 In vascular injury models , Serp-1 altered early cellular plasminogen activator ( ) , *inhibitor* ( [PAI-1] ) , and receptor ( urokinase-type plasminogen activator ) expression ( p < 0.01 ) . Negative_regulation SERPINE1 PLAT 14730909 1181916 The antithrombotic mechanism of novel compounds is not relevant to hemostatic systems or functions of platelet aggregation directly , but they can promote endothelial cells to release and *inhibit* the activity of [plasminogen activator inhibitor-1] ( PAI-1 ) . Negative_regulation SERPINE1 PLAT 15060421 1230516 We compared fibrinolytic parameters <[tissue-type plasminogen activator> ( t-PA ) , plasminogen activator *inhibitor* ( [PAI-1] ) , euglobulin clot lysis time ] measured in the femoral vein with those in the right atrium . Negative_regulation SERPINE1 PLAT 17097821 1716648 In vitro studies have demonstrated that statins can induce and *inhibit* [plasminogen activator inhibitor-1] , the major inhibitor of tPA . Negative_regulation SERPINE1 PLAT 17181930 1662656 Plasma plasminogen activator *inhibitor* ( [PAI-1] ) , antigens ( Ag ) and high sensitive C-reactive protein ( hs-CRP ) levels were measured during low salt intake at baseline . Negative_regulation SERPINE1 PLAT 1776334 175786 Platelet aggregation and the plasma levels/activity of plasminogen activator ( ) and its *inhibitor* ( [PAI-1] ) were determined . Negative_regulation SERPINE1 PLAT 1920864 168494 Since disseminated intravascular coagulation ( DIC ) may directly reflect the abnormal regulation of the fibrinolytic system by endothelial cells , we have measured the levels of , type 1 PA *inhibitor* ( [PAI-1] ) and t-PA . Negative_regulation SERPINE1 PLAT 19621739 1358650 We were especially interested in the study of the changing fibrinolytic system parameters such as , plasminogen activator *inhibitor* ( [PAI-1] ) , plasminogen , alpha2-antiplasmin activities . Negative_regulation SERPINE1 PLAT 20051227 2200927 We tested the hypothesis that leptin induces [PAI-1] and *inhibits* expression using human coronary artery endothelial cells ( HCAEC ) in culture as these cells play an important role in atherosclerosis . Negative_regulation SERPINE1 PLAT 20160640 2227791 The fibrinolytic activity of blood is regulated by expressing and its specific inhibitor , type-1 plasminogen activator *inhibitor* ( [PAI-1] ) , from vascular endothelial cells . Negative_regulation SERPINE1 PLAT 2460455 98571 Cyclic AMP potentiates phorbol ester stimulation of release and *inhibits* secretion of [plasminogen activator inhibitor-1] from human endothelial cells . Negative_regulation SERPINE1 PLAT 3146134 102041 In this study , the importance of anthropometric , nutritional and endocrine variables on the plasma concentrations of tissue plasminogen activator antigen ( ) and plasminogen activator *inhibitor* ( [PAI-l] ) were investigated . Negative_regulation SERPINE1 PLAT 7952409 277542 Samples were assayed for coagulation factors ( fibrinopeptide A , antithrombin III , protein C ) , fibrinolytic factors <[tissue-type plasminogen activator> ( t-PA ) , alpha 2 antiplasmin , plasminogen activator *inhibitor* ( [PAI-1] ) ] and markers of platelet activation ( platelet factor 4 , beta thromboglobulin ) . Negative_regulation SERPINE1 PLAT 8264050 239269 The balance between the EC-derived fibrinolytic components , plasminogen activator ( ) , and plasminogen *inhibitor* ( [PAI-1] ) contributes to maintaining thromboresistance . Negative_regulation SERPINE1 PLAT 8330376 223563 Transferable lipids in oxidized low-density lipoprotein stimulate [plasminogen activator inhibitor-1] and *inhibit* release from endothelial cells . Negative_regulation SERPINE1 PLAT 8614068 353592 Serial blood samples were obtained via femoral venous catheters for tissue plasminogen activator (tPA) , plasminogen activator *inhibitor* ( [PAI-1] ) , tPA-PAI-1 complex ( ) , and euglobulin lysis time ( ELT ) from all subjects and for fibrin degradation products ( FbDP ) and fibrinogen degradation products (FgDP) from phase II subjects . Negative_regulation SERPINE1 PLAT 8840002 386669 One week before and 1 week after the conditioning programs data were collected for body weight , percentage body fat , VO2 max and 12 h fasting blood levels of total , tissue-type plasminogen activator activity ( t-PAa ) , total plasminogen activator *inhibitor* ( [PAI-1] ) , plasminogen activator inhibitor activity ( PAI-1a ) , cholesterol ( CHOL ) , triglycerides ( TG ) , and high-density lipoprotein cholesterol ( HDL-C ) . Negative_regulation SERPINE1 PLAT 8888658 391618 Hormone replacement therapy in postmenopausal women has been shown to enhance fibrinolytic capacity by lowering [plasminogen activator inhibitor-1] ( PAI-1 ) and tissue plasminogen activator *inhibitor* ( ) antigen values . Negative_regulation SERPINE1 PLAU 10094378 601102 Ninety-eight patients with histologically confirmed ovarian tumors ( 77 primary ovarian carcinomas of stages T1 to T3 according to the postoperative histopathological classification pTNM classification , 14 ovarian metastases of various origins and seven benign ovarian tumors ) were investigated with regard to the concentration of urokinase-type plasminogen activator ( ) and plasminogen activator *inhibitor* ( [PAI-1] ) in membrane extracts of tumors . Negative_regulation SERPINE1 PLAU 10098758 601735 Prognostic impact of urokinase-type plasminogen activator ( ) and its *inhibitor* ( [PAI-1] ) in cytosols and pellet extracts derived from 892 breast cancer patients . Negative_regulation SERPINE1 PLAU 10098758 601737 To evaluate the clinical relevance of urokinase-type plasminogen activator ( ) and its type-1 *inhibitor* ( [PAI-1] ) measured by a recently developed enzyme linked immunosorbent assay ( ELISA ) , we analysed both components in samples derived from 892 patients with primary breast cancer ( median follow-up 99 months ) . Negative_regulation SERPINE1 PLAU 10430786 633627 The complex between urokinase ( ) and its type-1 *inhibitor* ( [PAI-1] ) is formed exclusively from the active forms of these components ; Negative_regulation SERPINE1 PLAU 10995898 733657 The serine protease urokinase-type plasminogen activator ( ) , its *inhibitor* ( [PAI-1] ) , and its receptor ( uPAR ; Negative_regulation SERPINE1 PLAU 11268487 764559 The aim of the study was to evaluate the prognostic significance of tumour and serum concentrations of ( uPA ) , its type 1 *inhibitor* ( [PAI-1] ) and cathepsin D (Cath D) in patients with squamous cell carcinoma of the head and neck ( SCCHN ) . Negative_regulation SERPINE1 PLAU 11286474 799863 Whereas HMEC-proliferation was stimulated by AR , the levels of secreted urokinase-type plasminogen activator ( ) and type-1 plasminogen activator *inhibitor* ( [PAi-1] ) remained unaffected . Negative_regulation SERPINE1 PLAU 11489825 845425 Recent studies suggest that HER-2/neu specifically promotes the invasive capacity of tumor cells by up-regulating secretion of the proteolytic enzyme , urokinase-type plasminogen activator ( ) , or its *inhibitor* , [plasminogen activator inhibitor-1] ( PAI-1 ) , in colon and gastric cancer . Negative_regulation SERPINE1 PLAU 11792750 901957 Urokinase-type plasminogen activator ( ) and its *inhibitor* ( [PAI-1] ) play essential roles in tumor invasion and metastasis . Negative_regulation SERPINE1 PLAU 12168869 973711 The plasminogen activator system , including urokinase-type plasminogen activator ( ) and type-1 plasminogen activator *inhibitor* ( [PAI-1] ) , plays an important role in repair of the peritoneum damaged by several types of peritonitis . Negative_regulation SERPINE1 PLAU 12402308 1009509 In our study , we have studied the effects of CD44 stimulation by ligation with HA upon the expression of matrix metalloproteinases ( MMPs ) -2 and -9 as well as urokinase-type plasminogen activator ( ) , its receptor ( uPAR ) and its *inhibitor* ( [PAI-1] ) and the subsequent induction of invasion of human chondrosarcoma cell line HCS-2/8 . Negative_regulation SERPINE1 PLAU 12466358 1022346 The regulated expression of the urokinase-type plasminogen activator ( ) and plasminogen activator *inhibitor* ( [PAI-1] ) is believed to modulate the invasive capacity of human trophoblastic cells in vitro and in vivo . Negative_regulation SERPINE1 PLAU 12642587 1085787 The plasminogen/plasmin system , urokinase-type plasminogen activator ( ) , its receptor ( uPAR ) , and its *inhibitor* ( [PAI-1] ) , influence extracellular proteolysis and cell migration in lung injury or neoplasia . Negative_regulation SERPINE1 PLAU 12706358 1082638 Immunoassays of urokinase ( ) and its type-1 *inhibitor* ( [PAI-1] ) in detergent extracts of breast cancer tissue . Negative_regulation SERPINE1 PLAU 12967140 1138861 Urokinase-type plasminogen activator ( ) , plasminogen activator *inhibitor* ( [PAI-1] ) , and uPA receptor (uPAR) are prognostic factors in various cancer types , especially breast cancer . Negative_regulation SERPINE1 PLAU 14744782 1203789 This system comprises of , among others , the urokinase-type plasminogen activator ( ) and its main *inhibitor* ( [PAI-1] ) . Negative_regulation SERPINE1 PLAU 14983227 1214585 The complex between urokinase-type plasminogen activator ( ) and its type-1 *inhibitor* ( [PAI-I] ) independently predicts response to first-line endocrine therapy in advanced breast cancer . Negative_regulation SERPINE1 PLAU 15061043 1230532 Immunohistochemical staining with tissue derived plasminogen activator ( tPA ) , urokinase derived plasminogen activator ( ) , plasminogen activator *inhibitor* ( [PAI-1] ) and von Willebrand Factor (vWF) was performed and analyzed with bright field microscopy . Negative_regulation SERPINE1 PLAU 15138856 1246931 This article examines the distribution and prognostic importance of urinase type plasminogen activators ( ) and of plasminogen activator *inhibitors* ( [PAI-1] ) in cases of primary oral squamous cell carcinoma . Negative_regulation SERPINE1 PLAU 15166500 1184472 To clarify the role of proteins involved in the regulation of fibrinolysis during corneal angiogenesis , we have studied corneal vessel formation in mice deficient for ( uPA ) , tissue-type plasminogen activator ( tPA ) , plasminogen , [plasminogen activator inhibitor-1] ( PAI-1 ) and thrombin-activatable fibrinolysis *inhibitor* ( TAFI ) . Negative_regulation SERPINE1 PLAU 15183949 1256021 To examine whether urokinase-type plasminogen activator ( ) and type 1 plasminogen *inhibitor* ( [PAI-1] ) , DNA ploidy , and S-phase fraction (SPF) add supplementary prognostic information relative to stage and Fuhrman 's grade in renal cell carcinoma . Negative_regulation SERPINE1 PLAU 15878520 1405982 The central role of the serine protease urokinase-type plasminogen activator ( ) and its *inhibitor* , the [plasminogen activator-inhibitor-1] ( PAI-1 ) , in tumour invasion and metastasis becomes more and more evident . Negative_regulation SERPINE1 PLAU 15970552 1423928 The plasminogen activation system in skeletal muscle regeneration : antagonistic roles of urokinase-type plasminogen activator ( ) and its *inhibitor* ( [PAI-1] ) . Negative_regulation SERPINE1 PLAU 16162159 1456144 The rat model of portal branch ligation ( PBL ) was compared with partial hepatectomy ( PH ) and sham operation ( SO ) and evaluated for the expression of heat shock protein-70 ( hsp70 ) , heme oxygenase-1 (hmox1) , early growth response gene-1 (Egr-1) and urokinase-type plasminogen activator ( ) , its *inhibitor* ( [PAI-1] ) and receptor ( uPAR ) . Negative_regulation SERPINE1 PLAU 16289236 1532320 The increased levels of urokinase-type plasminogen activator ( ) , uPA-receptor (uPAR) and type-1 PA *inhibitor* ( [PAI-1] ) are reported in human renal cell carcinoma (RCC) . Negative_regulation SERPINE1 PLAU 16309542 1486635 To verify the applicability of the cell invasion model , multilayer cell constructs of oral squamous cell carcinoma and oral mucosal fibroblasts were exposed to extrinsic urokinase-type plasminogen activator ( ) or plasminogen activator *inhibitor* ( [PAI-1] ) , which are known effectors of cell migration . Negative_regulation SERPINE1 PLAU 16325301 1511719 The complex between urokinase ( ) and its type-1 *inhibitor* ( [PAI-1] ) in pulmonary adenocarcinoma : relation to prognosis . Negative_regulation SERPINE1 PLAU 17136335 1653531 Higher levels of urokinase-type plasminogen activator ( ) and its *inhibitor* ( [PAI-1] ) are linked to the poor prognosis in a variety of malignances . Negative_regulation SERPINE1 PLAU 19082473 2018288 The serine protease urokinase-type plasminogen activator ( ) , its receptor ( uPAR ) and its *inhibitor* ( [PAI-1] ) are involved in the control of extracellular turnover , cell migration , invasion , cell signalling , proliferation , apoptosis and angiogenesis leading to a variety of different responses , under both physiological and pathological conditions . Negative_regulation SERPINE1 PLAU 20039121 2248038 Urokinase-type plasminogen activator ( ) and its main *inhibitor* ( [PAI-1] ) were shown with level 1 evidence to be prognostic factors for primary breast cancer . Negative_regulation SERPINE1 PLAU 20624254 2297083 Serum and induced sputum levels of urokinase-type plasminogen activator ( ) , urokinase-type plasminogen activator receptor ( uPAR ) , urokinase-type plasminogen activator *inhibitor* ( [PAI-1] ) and human cationic antimicrobial protein 18 ( CAP18 ) were measured by ELISA , in 13 patients with stage I or stage II COPD ( COPD I + II ) , 15 patients with stage III or stage IV COPD ( COPD III + IV ) , 18 healthy non-smokers and 14 healthy smokers . Negative_regulation SERPINE1 PLAU 21459526 2422638 The serine protease urokinase-type plasminogen activator ( ) and its *inhibitor* ( [PAI-1] ) play key roles in the proteolytic cascade involved in physiological and pathological degradation of the extracellular matrix . Negative_regulation SERPINE1 PLAU 21989445 2493478 Prognostic significance of urokinase-type plasminogen activator ( ) and plasminogen activator *inhibitor* ( [PAI-1] ) in patients with primary invasive ductal breast carcinoma - a 7.5-year follow-up study . Negative_regulation SERPINE1 PLAU 21989445 2493482 Urokinase-type plasminogen activator ( ) and plasminogen activator *inhibitor* ( [PAI-1] ) are key molecules in pericellular proteolysis , a process that plays an important role in tumor invasion and metastasis . Negative_regulation SERPINE1 PLAU 22140072 2557875 We show that CSP , an intervention targeting this pathway , protects the lung epithelium from apoptosis and prevents PF in BLM induced lung injury via mediated *inhibition* of p53 and [PAI-1] . Negative_regulation SERPINE1 PLAU 22467324 2578605 Expression of urokinase-type plasminogen activator ( ) , its receptor ( uPAR ) , and *inhibitor* ( [PAI-1] ) in human breast carcinomas and their clinical relevance . Negative_regulation SERPINE1 PLAU 24447806 2927151 In diabetic rats , *down-regulated* [PAI-1] and collagen IV expression in mesangial matrix ( P < 0.05 ) . Negative_regulation SERPINE1 PLAU 25075085 2953928 Clinical significance of urokinase-type plasminogen activator ( ) and its type-1 *inhibitor* ( [PAI-1] ) for metastatic sentinel lymph node involvement in breast cancer . Negative_regulation SERPINE1 PLAU 25075085 2953930 Urokinase-type plasminogen activator ( ) and its type-1 *inhibitor* ( [PAI-1] ) are key factors for tumor invasion and development of metastases in breast cancer . Negative_regulation SERPINE1 PLAU 7929271 274346 The alpha 2-macroglobulin receptor/low density lipoprotein receptor related protein ( alpha 2MR/LRP ) binds several ligands , including complex between the two chain urokinase-type plasminogen activator ( ) and type-1 plasminogen activator *inhibitor* ( [PAI-1] ) , and the single chain zymogen pro-urokinase ( pro-uPA ) . Negative_regulation SERPINE1 PLAU 8062262 268566 We have studied the prognostic value of urokinase-type plasminogen activator ( ) , uPA receptor (uPAR) , and type 1 plasminogen activator *inhibitor* ( [PAI-1] ) in tumor extracts from 84 patients with squamous cell lung carcinoma and 38 patients with large cell lung carcinoma , measuring each molecule with sandwich enzyme linked immunosorbent assays . Negative_regulation SERPINE1 PLAU 8261432 246652 We have studied the prognostic value of urokinase-type plasminogen activator ( ) and type-1 plasminogen activator *inhibitor* ( [PAI-1] ) in tumor extracts from 106 patients with adenocarcinoma of the lung . Negative_regulation SERPINE1 PLAU 8388317 218247 The prognostic value of urokinase-type plasminogen activator ( ) and type 1 plasminogen activator *inhibitor* ( [PAI-1] ) levels in cytosolic extracts of ductal breast carcinomas was studied , retrospectively , in 118 premenopausal and 72 postmenopausal high-risk patients entered into the protocol of Danish Breast Cancer Cooperative Group trials for adjuvant treatment of breast cancer . Negative_regulation SERPINE1 PLAU 8624901 354957 To evaluate the role of plasminogen activators ( tPA ) and *inhibitor* ( [PAI-1] ) in the pathogenesis of preeclampsia . Negative_regulation SERPINE1 PLAU 8703368 371082 The plasminogen and plasmin system , which is mainly regulated by urokinase-type plasminogen activator ( ) , its receptor ( uPAR ) and its *inhibitor* ( [PAI-1] ) , is generally believed to play a role in cancer invasion and metastasis . Negative_regulation SERPINE1 PLAU 8830927 385640 This review focuses on the main components of the fibrinolytic system -- tissue plasminogen activator (tPA) , urokinase ( ) and plasminogen activator *inhibitor* ( [PAI-1] ) -- and on thrombin . Negative_regulation SERPINE1 PLAU 8925884 359046 To clarify the specific expression and regulation of mRNAs for urokinase ( ) , its receptor ( uPAR ) , and type-1 plasminogen activator *inhibitor* ( [PAI-1] ) , I analyzed RNA from four human cancer cell lines by RNA blotting after treatment with cycloheximide , anisomycin , emetine or puromycin . Negative_regulation SERPINE1 PLAU 9194591 438169 Evidence has accumulated that urokinase-type plasminogen activator ( ) , its *inhibitor* ( [PAI-1] ) and receptor ( uPAR ) are involved in tumor invasion and metastasis . Negative_regulation SERPINE1 PLAU 9264575 449340 The levels of plasminogen activator urokinase ( ) and of its *inhibitor* ( [PAI-1] ) were measured by use of ELISA in the cytosol of tissue homogenates obtained from endometrial carcinomas and the marginal , tumor-free endometrium of postmenopausal patients ( n = 64 ) . Negative_regulation SERPINE1 PLAU 9272300 450573 To evaluate the effect of therapeutic and pharmacologic concentrations of two non-steroidal anti-inflammatory drugs ( NSAIDs ) , nimesulide and naproxen , on the synthesis of urokinase ( ) , plasminogen activator *inhibitor* ( [PAI-1] ) and interleukin-6 (IL-6) in human synovial fibroblasts isolated from osteoarthritis ( OA ) patients . Negative_regulation SERPINE1 PLAU 9815678 479514 We have reported previously that both urokinase-type plasminogen activator ( ) and its type 1 *inhibitor* ( [PAI-1] ) are statistically significant prognostic variables in patients with high-risk breast cancer ( Grondahl-Hansen et al. , Cancer Res. , 53 : 2513-2521 , 1993 ) , and we recently described that the uPA receptor (uPAR) is a prognostic marker in postmenopausal , node positive breast cancer patients ( Grondahl-Hansen et al. , Clin . Negative_regulation SERPINE1 PLAU 9815897 345396 We have recently described the urokinase-type plasminogen activator ( ) and its type 1 *inhibitor* ( [PAI-1] ) as strong prognostic variables in breast cancer ( J. A. Foekens et al. , Cancer Res. , 52 : 6101-6105 , 1992 ; Negative_regulation SERPINE1 TNF 12598326 1062055 Divergent *roles* for p55 and p75 receptors in the induction of [plasminogen activator inhibitor-1] . Negative_regulation SERPINE1 TNF 1391943 198789 Enzyme linked immunosorbent assay and immunoneutralization experiments indicate that and interleukin-1 alpha (IL-1 alpha) do not *contribute* to the postoperative plasma effect on HUVEC [PAI-1] synthesis . Negative_regulation SERPINE2 TNF 17073633 1637788 In the present review we attempt to summarize the majority of these , including the genes of matrix metalloproteinases and their *inhibitors* , elastin , [serpine2] , - a , transforming growth factor beta , a variety of interleukins and their receptors and antagonists , high affinity IgE receptor , human calcium activated chloride channel 1 , heme oxygenase , vascular endothelial growth factor , microsomal epoxide hydrolase , glutathione S-transferase , cytochrome P45O , superoxide dismutase , vitamin D binding protein , beta2-adrenergic receptor , Toll like receptor , human B defensins , mucins , cystic fibrosis transmembrane regulator , surfactant protein and Nuclear Factor E2 Related Factor 2 . Negative_regulation SERPINF1 PLAU 18487955 1951692 Blocking of and uPAR on the cell surface *increased* the binding of [PEDF] , whether endogenous or exogenous . Negative_regulation SERPINF2 PLAT 8836361 386262 To evaluate the ability of commercial , chromogenic kits designed to measure human fibrinolytic pathway components to measure the canine plasma fibrinolytic pathway enzymes , and plasminogen (PLG) , and their respective *inhibitors* , plasminogen activator inhibitor 1 (PAI) and [alpha 2-antiplasmin (AP)] . Negative_regulation SETD2 CTGF 23530034 2777438 Notably , silencing of endogenous *increased* [HIF-1a] levels and its target gene expression , suggesting a role for CCN2 in controlling basal HIF-1a levels . Negative_regulation SETD2 EGLN3 16407229 1533628 Suppression of Morg1 or by stealth RNA *leads* to a marked increase of [HIF-1] activity . Negative_regulation SETD2 EPHB2 12447987 1032128 *Role* of and calcium in the hypoxia induced activation of [HIF-1] . Negative_regulation SETD2 EPHB2 21411223 2421281 Compared with corresponding control cells , A431-Ras cells exhibited marked resistance to the EGFR inhibitors cetuximab and gefitinib , reducing inhibition of Akt and phosphorylation , *inhibition* of [HIF-1a] expression and transcriptional activity , and antitumor effects in vitro and in vivo . Negative_regulation SETD2 EPHB2 23869238 2817629 BBR also downregulated [HIF-1a] and VEGF expression and *inhibited* Akt and phosphorylation . Negative_regulation SETD2 FHL1 23086815 2690459 *inhibited* [HIF1] transcriptional activity and HIF1 mediated VEGF expression in a hypoxia independent manner . Negative_regulation SETD2 FHL1 23086815 2690460 Moreover , *blocked* HIF1a-HIF1ß heterodimerization and [HIF1a] recruitment to the VEGF promoter . Negative_regulation SETD2 FOXO1 21696576 2451583 In addition , cell culture experiments showed that suppression *increased* the mRNA and protein expressions of [HIF-1a] . Negative_regulation SETD2 PGC 22266669 2580052 Under the condition of hypoxia concomitant with serum deprivation , the overexpression of in MSCs *resulted* in a higher expression level of [hypoxia-inducible factor-1a (Hif-1a)] , a greater ratio of B-cell lymphoma leukemia-2 (Bcl-2)/Bcl-2 associated X protein (Bax) , and a lower level of caspase 3 compared with the controls , followed by an increased survival rate and an elevated expression level of several proangiogenic factors . Negative_regulation SETD2 SPHK1 21392092 2453287 Consistently , siRNA-SPHK1 and sphingosine kinase inhibitor (SKI) effectively blocked the expression of HIF-1a , phospho-AKT and vascular endothelial growth factor ( VEGF ) production in PC-3 cells under hypoxia , suggesting the *role* of in melatonin inhibited [HIF-1a] accumulation . Negative_regulation SETD2 TCN1 18639543 1954651 Furthermore , *prevented* hypoxia induced expression of [HIF-1] target genes for vascular endothelial growth factor ( VEGF ) and erythropoietin . Negative_regulation SETD2 TGM2 18375543 1938218 protects against ischemic insult , interacts with HIF1beta , and *attenuates* [HIF1] signaling . Negative_regulation SFN CCND1 16170570 1500415 At high doses ( > 25 microM ) , [SFN] dramatically *induces* the expression of p21 ( CIP1 ) while significantly inhibits the expression of the G ( 1 ) phase cell cycle regulatory genes such as , cyclin A , and c-myc . Negative_regulation SFTPC TUB 23825022 2834585 The underlying cause is likely due to reduced levels of Tub4 , as overexpression of *suppressed* the spindle and chromosome segregation defects in [spc98/+] mutants . Negative_regulation SGMS1 TNF 9813032 546041 In parallel with ceramide generation , mediated *inhibition* of glucosylceramide and [sphingomyelin (SM) synthase] prevents the immediate metabolization of this lipid mediator . Negative_regulation SGMS2 TNF 9813032 546040 In parallel with ceramide generation , *mediated* inhibition of glucosylceramide and [sphingomyelin (SM) synthase] prevents the immediate metabolization of this lipid mediator . Negative_regulation SGOL1 TNF 22025632 2508072 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation SGOL2 TNF 22025632 2508081 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation SH3TC1 RAB11A 20826437 2318748 Consistent with a function of Rab11 in Schwann cell myelination , SH3TC2 mutations that cause neuropathy disrupt the [SH3TC2/Rab11] interaction , and forced expression of dominant negative strongly *impairs* myelin formation in vitro . Negative_regulation SHBG IL1B 9366498 463321 The cytokine completely *blocked* the tamoxifen dependent induction of [SHBG] gene expression in HepER3 cells , but only partly blocked the effect of moxestrol mediated by the ER . Negative_regulation SHBG TNF 22210320 2544319 *induced* reduction of [SHBG] expression was mediated by downregulating HNF4A . Negative_regulation SHC1 EPHB2 9165038 432221 In contrast , expression of the MAP kinase phosphatase ( MKP-1 ) completely prevented activation but did not *inhibit* the serine phosphorylation of 66-kDa [Shc] . Negative_regulation SHC1 TNF 10764814 698920 Insulin induced phosphorylation of [Shc] was *inhibited* by in a similar pattern . Negative_regulation SHH EPHB2 17299056 1711285 FGF mediated inhibition of [Shh] responses *requires* activation of FGF receptors and of and JNK kinases , because it can be blocked by inhibitors of these enzymes . Negative_regulation SHH IL1B 19883649 2203391 produced during Helicobacter infection *inhibited* gastric acid , intracellular calcium , and [Shh] expression through the IL-1 receptor . Negative_regulation SHH IL1B 19883649 2203392 did not *suppress* [Shh] expression in primary gastric mucous cells . Negative_regulation SHH WIF1 19700758 2133289 Furthermore , BMP signaling stimulated expression and promoter activity in cultured tumor cells and HaCaT keratinocytes , as well as *inhibited* [Shh] expression , as compared with the corresponding controls . Negative_regulation SIAH1 SNCAIP 19224863 2061655 *inhibits* [seven in absentia homolog (SIAH)] and modulates alpha-synuclein monoubiquitylation and inclusion formation . Negative_regulation SIAH2 SNCAIP 19224863 2061656 *inhibits* [seven in absentia homolog (SIAH)] and modulates alpha-synuclein monoubiquitylation and inclusion formation . Negative_regulation SIAH3 SNCAIP 19224863 2061657 *inhibits* [seven in absentia homolog (SIAH)] and modulates alpha-synuclein monoubiquitylation and inclusion formation . Negative_regulation SIN3A TNF 7691816 230980 In addition the cytokines interleukin-1 , -6 , and *mediate* a decrease in hepatic [SAP] ( FP ) transcript levels in female hamsters but did not cause a significant elevation of SAP ( FP ) mRNA in livers of male hamsters . Negative_regulation SIRT1 TNF 23075766 2710534 *reduced* [SIRT1] expression and induced CD40 expression in CRL-1730 endothelial cells in a time- and concentration- dependent manner . Negative_regulation SIRT5 PGC 24687991 2949235 Overexpression of in mouse primary hepatocytes *increased* [SIRT5] mRNA expression 4-fold and also the protein in a peroxisome proliferator activated receptor a ( PPARa ) - and estrogen related receptor a ( ERRa ) -dependent manner . Negative_regulation SKA1 TNF 22025632 2508074 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation SKA2 TNF 22025632 2508073 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation SKIV2L SPHK1 19036099 2022981 In particular , [SKI] *induced* an early , significant inhibition of activity , impaired cell cycle progression and triggered apoptosis in K562 cells . Negative_regulation SKP1 FGD3 18363964 1887895 Here we show that , which was identified as a homologue of FGD1 but has been poorly characterized , has conserved the same motif and is *down-regulated* similarly by [SCF] ( FWD1/beta-TrCP ) . Negative_regulation SKP2 CCND1 21931116 2506991 Mechanistically , we show that [Skp2] deficiency *induces* gene expression , which contributes to an increase in HSC cycling . Negative_regulation SKP2 EPHB2 24177224 2868304 *dependent* downregulation of [Skp2] reduces Myc activity with HGF , leading to inhibition of cell proliferation through a decrease in Id1 expression . Negative_regulation SKP2 EPHB2 24177224 2868316 Overall , these mechanistic findings provide the first evidence that *dependent* downregulation of [Skp2] reduced Myc activity , leading to HGF induced inhibition of cell proliferation through decreased Id1 expression . Negative_regulation SLAMF1 ID1 17622570 1792793 Consistent with this expression pattern , deficiency *led* to a 2-fold reduction in the number of LT-HSCs defined as Lin ( - ) Sca1 ( + ) c-kit ( Hi ) CD48 ( - ) [CD150] ( + ) . Negative_regulation SLC10A1 TNF 22290395 2617476 Furthermore , and transforming growth factor-ß1 induced the expression of Lpcat2/4 and Abcc1/4 and *down-regulated* [Slc10a1] and Slco1a1 in primary hepatocytes , suggesting an association between the changes in serum LPC and bile acids and proinflammatory cytokines . Negative_regulation SLC12A9 EPHB2 20855497 2325792 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( [Waf1/Cip1] ) cyclin dependent kinase inhibitor , and induction of senescence . Negative_regulation SLC12A9 FAS 14767544 1207627 In SK-Br3 cells , cerulenin induced inhibition of activity *resulted* in down-regulation of p53 , and up-regulation of cyclin dependent kinase inhibitor (CDKi) [p21WAF1/CIP1] . Negative_regulation SLC12A9 MAP2K6 10597223 573367 [p21Cip1/Waf1] cyclin dependent kinase inhibitor ( p21 ) is *inducible* by Raf and ( MAPKK ) , but the level of regulation is unknown . Negative_regulation SLC15A2 EGF 14559717 1186092 These findings demonstrate for the first time *mediated* regulation of [PEPT2] expression in a kidney cell line . Negative_regulation SLC16A3 BRCA1 23172369 2707682 Co-culture with HCC1937 cells dramatically induces [MCT4] protein expression in fibroblasts , and this can be *prevented* by either overexpression or by pharmacological treatment with NAC . Negative_regulation SLC16A3 DNM1 23033272 2702576 Furthermore , inhibition of *resulted* in enhanced expression of hypermethylated genes ( Bcl3 and [Slc16a3] ) in the decidual bed as compared with control , indicating aberration of gene expression may be associated with DNM-inhibition induced decidual perturbation . Negative_regulation SLC16A3 NA 23860378 2829919 also *blocked* stromal induction of [MCT4] , indicating that NAC effectively functions as an `` MCT4 inhibitor '' . Negative_regulation SLC1A1 RARB 19450544 2120301 The ATRA dependent overexpression of the glutamate transporter [EAAC1] *requires* induction . Negative_regulation SLC1A2 TNF 18381653 1913016 However , while is *essential* for hypoxic suppression of [EAAT-2] , hypoxic modulation of EAAT-1 expression is unaffected by this cytokine . Negative_regulation SLC1A3 TNF 14713304 1181665 Conversely , *reduced* both EAAT promoter activity and cellular [EAAT1] mRNA expression . Negative_regulation SLC22A3 EPHB2 15548370 1338394 However , the *role* of in the induction of TGF-beta1 mediated [EMT] remains unclear . Negative_regulation SLC22A3 FOXA1 20160041 2214994 In PDA cell lines , FOXA1/2 expression is consistently suppressed in experimental EMT models and RNAi silencing of alone is *sufficient* to induce [EMT] . Negative_regulation SLC22A3 FOXA1 20160041 2214995 We conclude that suppression of expression is both necessary and *sufficient* for [EMT] during PDA malignant progression . Negative_regulation SLC22A3 MMP7 20584780 2290649 Gastrin and siRNAs and MMP-7 neutralising antibody significantly reduced upregulation of HB-EGF shedding in H pylori infected gastric cell lines and *reduced* [EMT] gene expression . Negative_regulation SLC22A3 MUC16 21326240 2403906 The *role* of in [EMT] was investigated using single-chain antibody mediated knockdown of cell surface CA125/MUC16 in overexpressing EOC NIH : OVCAR3 cells . Negative_regulation SLC22A3 PGC 22608985 2614530 RNAi mediated suppression of PGC-1a induced MtD and [EMT] , whereas overexpression of *prevented* Aldo induced MtD and inhibited EMT . Negative_regulation SLC22A3 PLAU 24195704 2883016 In a recent study published in Respiratory Research , Qin Wang and colleagues investigated the *role* of receptor ( uPAR ) in [EMT] in small airway epithelium of COPD patients . Negative_regulation SLC22A3 TP63 23658742 2784760 We therefore investigated the *role* of in [EMT] . Negative_regulation SLC23A2 EPHB2 19232538 2054697 Activation of was sustained up to 48 h after PMA treatment , and the inhibitors completely *blocked* PMA stimulated [SVCT2] protein expression , indicating an exclusive role for the classical MAP kinase pathway . Negative_regulation SLC23A2 MAP2K6 19232538 2054703 Activation of was sustained up to 48 h after PMA treatment , and the inhibitors completely *blocked* PMA stimulated [SVCT2] protein expression , indicating an exclusive role for the classical MAP kinase pathway . Negative_regulation SLC25A1 TNF 10734122 678730 *inhibits* expression of [CTP] : phosphocholine cytidylyltransferase . Negative_regulation SLC25A1 TNF 10734122 678731 *reduced* the activity of [CTP] : phosphocholine cytidylyltransferase ( CCT ) , the rate-regulatory enzyme within the CDP-choline pathway , by 40 % compared with control , but it did not alter activities of choline kinase or cholinephosphotransferase . Negative_regulation SLC25A1 TNF 11404253 825254 Am J Physiol Lung Cell Mol Physiol 281 : L98-L107 , 2001 ) , we demonstrated that *inhibited* the activity of [CTP] : phosphocholine cytidylyltransferase ( CT ) , the rate limiting enzyme in the de novo synthesis of phosphatidylcholine ( PC ) , and that its actions were likely exerted through a metabolite of sphingomyelin . Negative_regulation SLC25A3 CD22 8627166 355808 Transient expression of and a null mutant of PTP-1C ( PTP-1CM ) in COS cells *resulted* in an increase in tyrosyl phosphorylation of CD22 and its interaction with [PTP-1CM] . Negative_regulation SLC25A3 TNF 21246001 2379916 The levels of MPO , endotoxin , serum DAO , and IL-10 at T1-T6 , and level at T1-T4 *increased* in groups LIR and [PHC] ( P < 0.05 ) compared with those in group S , but tissue DAO and SOD activity at T1-T6 decreased ( P < 0.05 ) . Negative_regulation SLC26A3 CTGF 17052405 1636207 This study investigated the *role* of in hyperoxia induced [CLD] . Negative_regulation SLC26A3 IL1B 9843783 553609 *reduced* [DRA] mRNA expression in vitro by inhibiting gene transcription . Negative_regulation SLC26A3 PDZK1 19447883 2101467 DRA also possesses a PDZ binding motif , but the *roles* of interactions with E3KARP or and Ca ( 2+ ) ( i ) in [DRA] regulation are unknown . Negative_regulation SLC26A3 PDZK1 19447883 2101478 In HEK cells , which express little PDZK1 , additional transfection of was *required* for UTP to inhibit [DRA] . Negative_regulation SLC26A6 PDZK1 17120766 1652188 Finally , we demonstrated an essential *role* for the scaffolding protein in apical membrane expression of [SLC26A6] . Negative_regulation SLC27A1 TNF 22771331 2634532 ( TNFa ) ( 100 ng/ml ) *reduced* [FATP1] expression in isolated adipocytes . Negative_regulation SLC27A2 FOXA1 22238690 2538043 Moreover , *represses* the fatty acid transporter protein [FATP2] and lowers fatty acid uptake . Negative_regulation SLC28A1 INS 17537394 1778403 In the primary culture of rat CFs , increased the mRNA level of ENT2 and *suppressed* the [CNT1] and CNT2 mRNA levels . Negative_regulation SLC28A1 NR0B2 19228884 2050429 In cotransfection experiments , the transcriptional coactivator peroxisome proliferator activated receptor-gamma coactivator-1alpha further increased , whereas the bile acid-inducible corepressor *reduced* , HNF-4alpha dependent [CNT1] promoter activity . Negative_regulation SLC2A1 EPHB2 21846809 2500936 Inhibition of the p38 MAPK pathway reduced Slc7a1 mRNA expression while inhibition of *increased* [Slc2a1] mRNA expression . Negative_regulation SLC2A4 FOXO1 12414908 1011213 Therefore , we evaluated the *role* of in the regulation of [GLUT4] gene expression in muscle tumorigenesis . Negative_regulation SLC2A4 FOXO1 18077353 1836825 Importantly , mediated increases in Akt activity diminish insulin signaling , as manifested by reduced Akt phosphorylation , *reduced* membrane translocation of [Glut4] , and decreased insulin triggered glucose uptake . Negative_regulation SLC2A4 FOXO1 20406953 2274258 The negative effect of over PPARG transcription disappears when FOXO1 is phosphorylated ( p-FOXO1 ) and excluded from the nucleus , whereas PPARG can *suppress* gene expression of [SLC2A4] . Negative_regulation SLC2A4 MAP2K6 11279172 819616 Constitutively active mutants up-regulated GLUT1 expression and *down-regulated* [GLUT4] expression , thereby significantly increasing basal glucose transport but diminishing transport induced by insulin . Negative_regulation SLC2A4 RAB31 17189207 1680082 Overexpression of *blocks* insulin stimulated [Glut4] translocation , whereas knockdown of Rab31 potentiates insulin stimulated Glut4 translocation and glucose uptake . Negative_regulation SLC2A4 TNF 12773307 1113385 Taken together , these results suggest that *induced* desensitization of endothelin-1 stimulated [GLUT4] translocation and glucose uptake in 3T3-L1 adipocytes is due , at least in part , to a decreased expression of Galphaq/11 , leading to a suppression in tyrosine phosphorylation of PYK2 . Negative_regulation SLC2A4 TNF 1618860 191384 Transcriptional *repression* of the C/EBP-alpha and [GLUT4] genes in 3T3-L1 adipocytes by . Negative_regulation SLC2A4 TNF 1939208 170404 Transcriptional *repression* of the [GLUT4] and C/EBP genes in 3T3-L1 adipocytes by . Negative_regulation SLC2A4 TNF 20181658 2259182 Anti-TNF-alpha neutralization antibody and silencing of *diminished* the TCDD induced downregulation of IRbeta , IRS1 , and [GLUT4] . Negative_regulation SLC2A4 TNF 20181658 2259184 Taken together , TCDD stimulates expression and secretion of TNF-alpha in adipocytes through activation of AhR , ERK1/2 , and JNK , and the secreted *causes* the downregulation of IRbeta , IRS1 , and [GLUT4] through TNFR1 , resulting in insulin resistance . Negative_regulation SLC2A4 TNF 7956951 277898 Treatment of 3T3-L1 cells with troglitazone ( 1-10 microM ) partially prevented this inhibitory effect of TNF on adipogenesis , and enhanced expression of C/EBP alpha and [GLUT4] , even in the *presence* of . Negative_regulation SLC2A4 TNF 8995390 409497 These results are consistent with earlier studies indicating that *reduces* the transcriptional activity of the [GLUT4] gene in murine adipocytes , and reduced mRNA transcription of a number of relevant genes may be the general mechanism by which TNF-alpha causes insulin resistance in adipocytes . Negative_regulation SLC33A1 ARSA 22306536 2565233 In this study , we examined if would *inhibit* NADPH oxidase activation , upregulation of [AT1R] transcription , and subsequent collagen generation in mouse cardiac fibroblasts challenged with Ang II . Negative_regulation SLC33A1 ARSA 22306536 2565249 These observations suggest that *inhibits* Ang II-induced NADPH oxidase expression , NF-?B activation and [AT1R] transcription in cardiac fibroblasts , and fibroblast proliferation and collagen expression . Negative_regulation SLC33A1 ARSA 22306536 2565251 The critical role of NADPH oxidase activity in stimulation of AT1R transcription became apparent in experiments where also *inhibited* [AT1R] transcription in cardiac fibroblasts challenged with H2O2 . Negative_regulation SLC33A1 HSD11B2 12911547 1122122 Cortisol *enhanced* [AT1] receptor mRNA expression when the <11beta-HSD2> activity was reduced either by Ang II or by glycyrrhetinic acid , an 11beta-HSD2 inhibitor . Negative_regulation SLC38A3 HRAS 15331357 1287921 [G17] induction of Akt activation was *reduced* by > 60 % by both dominant negative and Rho and by 30 % by dominant negative Cdc42 . Negative_regulation SLC38A3 KRAS 15331357 1287922 [G17] induction of Akt activation was *reduced* by > 60 % by both dominant negative and Rho and by 30 % by dominant negative Cdc42 . Negative_regulation SLC38A3 NRAS 15331357 1287923 [G17] induction of Akt activation was *reduced* by > 60 % by both dominant negative and Rho and by 30 % by dominant negative Cdc42 . Negative_regulation SLC38A3 PBX2 6095679 43019 Proglumide , known to inhibit cholecystokinin binding to pancreatic acinar cell receptors , also inhibited 125I- [ Leu15 ] [G-17] binding to the SCEF and *inhibited* stimulated SLI release . Negative_regulation SLC38A3 RHO 15331357 1287920 [G17] induction of Akt activation was *reduced* by > 60 % by both dominant negative Ras and and by 30 % by dominant negative Cdc42 . Negative_regulation SLC38A3 RHOA 9950815 595756 Because activation of the SRE involves the small GTP binding protein Rho A , we examined the *role* of in [G17] induction of c-fos transcription . Negative_regulation SLC5A3 TNF 9882452 584154 In these studies we show that *causes* a concentration- and time dependent decrease in [Na+/myo-inositol cotransporter] ( SMIT ) mRNA levels and myo-inositol accumulation as well as a decrease in myo-inositol incorporation into phosphoinositides . Negative_regulation SLC5A5 MAP2K6 23404856 2759744 inhibition *leads* to lysosome mediated [Na+/I- symporter] protein degradation in human breast cancer cells . Negative_regulation SLC5A5 TNF 9449644 483851 , ceramide , transforming growth factor-beta1 , and aging *reduce* [Na+/I- symporter] messenger ribonucleic acid levels in FRTL-5 cells . Negative_regulation SLC6A2 CALM3 17032905 1674474 Amphetamine induces a *dependent* protein kinase II-dependent reduction in [norepinephrine transporter] surface expression linked to changes in syntaxin 1A/transporter complexes . Negative_regulation SLC6A2 DSP 21129451 2390072 *induced* a widespread loss of [norepinephrine transporter] binding in multiple brain structures already at 4.5 months . Negative_regulation SLC6A2 EDN1 16005303 1431202 *inhibits* the neuronal [norepinephrine transporter] in hearts of male rats . Negative_regulation SLC6A2 HDAC1 21098082 2377076 We found that inhibitors *caused* an increase in the amount of [norepinephrine transporter] expressed in tumors . Negative_regulation SLC6A2 HDAC2 21098082 2377077 We found that inhibitors *caused* an increase in the amount of [norepinephrine transporter] expressed in tumors . Negative_regulation SLC6A2 HTR1B 22401777 2587688 Conventional antidepressant properties for dextromethorphan and dextrorphan include 5HTT and [norepinephrine transporter] *inhibition* , s ( 1 ) stimulation , NMDA and PCP antagonism , and possible serotonin <5HT1b/d> receptor stimulation . Negative_regulation SLC6A2 RBBP4 21098082 2377078 We found that inhibitors *caused* an increase in the amount of [norepinephrine transporter] expressed in tumors . Negative_regulation SLC6A2 RBBP7 21098082 2377079 We found that inhibitors *caused* an increase in the amount of [norepinephrine transporter] expressed in tumors . Negative_regulation SLC6A2 SLC6A5 20547485 2302046 Consistent with these results , both dominant negative Smad3 and constitutively active Smad7 blocked the cytoplasmic localization of and *inhibited* interactions between [NET1] and RhoA . Negative_regulation SLC6A2 SMAD3 20547485 2302047 Consistent with these results , both dominant negative and constitutively active Smad7 blocked the cytoplasmic localization of NET1 and *inhibited* interactions between [NET1] and RhoA . Negative_regulation SLC6A2 SMAD7 20547485 2302048 Consistent with these results , both dominant negative Smad3 and constitutively active blocked the cytoplasmic localization of NET1 and *inhibited* interactions between [NET1] and RhoA . Negative_regulation SLC6A2 SNAI2 17146058 1661525 We also found that both and Scratch *repress* the [SLC6A2] promoter activity only when it contains the T allele . Negative_regulation SLC6A5 SLC6A2 20547485 2302049 Consistent with these results , both dominant negative Smad3 and constitutively active Smad7 blocked the cytoplasmic localization of [NET1] and *inhibited* interactions between and RhoA . Negative_regulation SLC8A1 EPHB2 12502566 1026776 Inhibition of ERK with the MEK inhibitor UO126 , the ERK protein phosphatase MKP-3 , inhibited activation , but only *inhibited* alpha-adrenergic induced [NCX1] upregulation by 30 % . Negative_regulation SLC9A1 EPHB2 15494214 1354863 These studies indicate a direct involvement of ERK in the alpha ( 1 ) -adrenergic activation of NHE1 and a significant *role* for both and RhoA in LPA stimulation of [NHE1] in CCL39 fibroblasts . Negative_regulation SLC9A1 EPHB2 17982256 1821108 Here , we show , using a combination of biochemical and molecular biology approaches , that three MAPKs exhibit unique interrelationships with the Na ( + ) /H ( + ) exchanger , NHE1 , after osmotic cell shrinkage : Extracellular Signal Regulated Kinase ( ERK1/2 ) is inhibited in an NHE1 dependent , pH(i) independent manner , c-Jun N-terminal kinase ( JNK1/2 ) is stimulated , in part through NHE1 mediated intracellular alkalinization , and p38 MAPK is activated in an NHE1 independent manner , and contributes to [NHE1] activation and *inhibition* . Negative_regulation SLC9A2 IFNG 11287336 800039 Chronic exposure of intestinal epithelial cells to *results* in selective downregulation of [NHE2] and NHE3 expression and activity , a potential cause of inflammation associated diarrhea . Negative_regulation SLC9A2 SLC9A3 10534423 562749 Salivarectomy did not influence [NHE-2] protein expression and *inhibited* the increased protein expression following SBR . Negative_regulation SLC9A2 SLC9A3 8244988 236717 Phorbol ester stimulated NHE1 and [NHE2] , but *inhibited* with a decrease in Vmax . Negative_regulation SLC9A2 SNAP25 12181191 977526 NHE3 activity was significantly *reduced* by ( P < 0.05 ) , whereas [NHE2] activity was essentially unaltered . Negative_regulation SLC9A3 EPHB2 12081562 958403 *Role* of c-SRC and in acid induced activation of [NHE3] . Negative_regulation SLC9A3 HSD11B2 12842861 1108460 Inhibition of <11betaHSD-2> activity by carbenoxolone during NaCl restriction *stimulated* [NHE-3] expression in colon . Negative_regulation SLC9A3 MAP2K6 21832242 2495669 LPA ( 5 ) -dependent *activation* of [NHE3] was blocked by ( MEK ) inhibitor PD98059 and U0126 , but not by phosphatidylinositol 3-kinase inhibitor LY294002 or phospholipase C-ß inhibitor U73122 . Negative_regulation SLC9A3 PDZK1 19535329 2121132 ( PDZK1 ) *contributes* to basal and calcium inhibition of [NHE3] activity in Caco-2BBe cells . Negative_regulation SLC9A3 PDZK1 24867958 2951168 protein heterodimerization and macrocomplex formation are *required* for the inhibition of [NHE3] activity by carbachol . Negative_regulation SLC9A3 SLC9A2 10534423 562750 Salivarectomy did not influence protein expression and *inhibited* the increased [NHE-3] protein expression following SBR . Negative_regulation SLC9A3 SLC9A2 8244988 236719 Phorbol ester stimulated NHE1 and , but *inhibited* [NHE3] with a decrease in Vmax . Negative_regulation SLC9A3 TNF 16760259 1624944 Our data indicate that IFN-gamma and may *repress* the [NHE3] promoter activity in C2BBe1 cells by PKA mediated phosphorylation of Sp1 and Sp3 transcription factors . Negative_regulation SLC9A3 TNF 18785066 2012160 These findings suggest a *role* of in the regulation of [NHE-3] expression in IBD . Negative_regulation SLC9A8 TNF 19109523 2042222 The downregulation of [NHE8] expression *mediated* by could be blocked by transcription inhibitor actinomycin D , suggesting the involvement of transcriptional regulation . Negative_regulation SLC9A8 TNF 19109523 2042223 Further studies indicated that the human NHE8 gene transcription could be activated by Sp3 transcriptional factor , and *inhibits* human [NHE8] expression by reducing Sp3 interaction at the minimal promoter region of the human NHE8 gene . Negative_regulation SLPI F2R 10457264 639286 Activation of by thrombin or SFFL *inhibited* endogenous [alkaline phosphatase (ALP)] activity and caused a transient elevation of intracellular calcium in the osteoblast-like cells . Negative_regulation SLPI FOXO1 11786925 901328 Reporter assays demonstrated that the overexpression of *stimulated* [ALP] promoter activity through the forkhead response element in its promoter . Negative_regulation SLPI IL1B 1640347 194773 On the other hand , significantly *inhibited* [alkaline phosphatase (ALP)] activity of the cells in a dose dependent manner . Negative_regulation SLPI IL1B 8020864 262896 TNF-alpha and significantly *inhibited* [ALP] production , decreased cellular Ca content , and significantly enhanced 45Ca release in human osteoblastic cells . Negative_regulation SLPI IL1B 8156283 253248 TNF-alpha and significantly *inhibited* [ALP] production , decreased cellular Ca content , and significantly enhanced 45Ca release in human osteoblastic cells . Negative_regulation SLPI TF 21308772 2431487 Interestingly , iron , particularly in its inorganic form , and to a lesser extent ferritin and all *suppressed* [alkaline phosphatase (ALP)] activities in osteoblasts . Negative_regulation SLPI TNF 10974633 729340 In contrast , *suppressed* [ALP] activity and F-actin accumulation induced by NaBt . Negative_regulation SLPI TNF 11827934 909546 ELISA showed that lipopolysaccharide activated M/Ms secreted , and neutralizing antibody to tumor necrosis factor-alpha *attenuated* the induction of [ALP] activity by the conditioned media . Negative_regulation SLPI TNF 12874244 1114994 Exposure of RAW264.7 cells to apoptotic CTLL-2 cells induced both SLPI and , and addition of IFN-gamma *inhibited* [SLPI] but augmented TNF-alpha production . Negative_regulation SLPI TNF 18310456 1879068 FPP and GGPP also restored the simvastatin effects on *induced* suppression of Runx2 and [ALP] activity . Negative_regulation SLPI TNF 18495459 2010392 The 5 , 10 and 20 microg/ml doses of polyphenols significantly increased intracellular ALP activity under normal conditions at 7 and 14 days , and restored the *induced* suppression of intracellular [ALP] activity by 14 days ( P < .001 ) . Negative_regulation SLPI TNF 20004646 2199809 MSX2 over-expression alone *induced* [ALP] expression , whereas knockdown of MSX2 with small interfering RNA completely blocked induced ALP expression . Negative_regulation SLPI TNF 20440096 2282718 In this study , we examined the role of Msx2 in *mediated* inhibition of [alkaline phosphatase (ALP)] expression and the signaling pathways involved . Negative_regulation SLPI TNF 20440096 2282722 *down-regulated* [ALP] expression induced by bone morphogenetic protein 2 (BMP2) in C2C12 and Runx2 ( -/- ) calvarial cells . Negative_regulation SLPI TNF 2109156 131147 also *inhibited* [alkaline phosphatase (ALP)] activity in the cells . Negative_regulation SLPI TNF 2109156 131148 The *induced* inhibition of proliferation and [ALP] activity was further potentiated by interferon (IFN) gamma . Negative_regulation SLPI TNF 22447223 2588499 ( 5 ng/mL ) *resulted* in an increase in apoptosis and a reduction in [ALP] activity in the cells . Negative_regulation SLPI TNF 8020864 262895 and IL-1 beta significantly *inhibited* [ALP] production , decreased cellular Ca content , and significantly enhanced 45Ca release in human osteoblastic cells . Negative_regulation SLPI TNF 8156283 253247 and IL-1 beta significantly *inhibited* [ALP] production , decreased cellular Ca content , and significantly enhanced 45Ca release in human osteoblastic cells . Negative_regulation SLPI TNF 9213003 441536 *suppressed* the induction of [ALP] by BMP-2 or -4 . Negative_regulation SLPI TNF 9383683 466230 IL-1 alpha and *inhibited* [alkaline phosphatase (ALP)] activity , which was significantly reversed by AG . Negative_regulation SMAD1 EPHB2 16135812 1450486 Pathway- and expression level dependent effects of oncogenic N-Ras : p27 ( Kip1 ) mislocalization by the Ral-GEF pathway and *mediated* interference with [Smad] signaling . Negative_regulation SMAD1 ID1 18436795 1915413 Furthermore , activation of ERK1/2 by platelet derived growth factor BB also caused [Smad1] linker region phosphorylation and *inhibited* BMP4 induced gene expression . Negative_regulation SMAD1 TNF 10903323 730705 *inhibits* transforming growth factor-beta [/Smad] signaling in human dermal fibroblasts via AP-1 activation . Negative_regulation SMAD1 TNF 10903323 730713 In this report , we demonstrate that *prevents* TGF-beta induced [Smad-specific] gene transactivation without inducing detectable levels of inhibitory Smad7 in human dermal fibroblasts . Negative_regulation SMAD1 TNF 10903323 730721 Expression of antisense c-Jun mRNA prevents *inhibition* of [TGF-beta/Smad] signaling whereas that of dominant negative Ikappa-B kinase-alpha or antisense Smad7 does not . Negative_regulation SMAD1 TNF 10903323 730732 Finally , we show that overexpression of the transcriptional co-activator p300 prevents *inhibition* of [TGF-beta/Smad] signaling . Negative_regulation SMAD1 TNF 12426318 1036650 We demonstrate that , in a cellular context devoid of JNK activity ( i.e. jnk ( -/- ) fibroblasts ) , interleukin-1 and did not *inhibit* the formation of SMAD-DNA complexes and the resulting [SMAD-driven] transcription in response to TGF-beta . Negative_regulation SMAD1 TNF 17266397 1725628 In vitro , *suppresses* BMP-2- and TGFbeta mediated [Smad] activation through induction of NF-kappaB . Negative_regulation SMAD1 TNF 17266397 1725662 In vitro , potently *suppressed* [Smad] signaling induced by TGFbeta and BMP-2 , downregulated BMP-2 mediated Runx2 expression , and inhibited mineralization of osteoblasts . Negative_regulation SMAD1 TNF 18310456 1879051 The ability of simvastatin to reverse *inhibition* of BMP induced [Smad1] ,5,8 phosphorylation and Id-1 promoter activity suggests the involvement of Smad signaling pathway in simvastatin action . Negative_regulation SMAD1 TNF 22897816 2734829 activated NF-?B pathway and *inhibited* the phosphorylation of [Smad 1/5/8] and BMP-2 induced osteoblastic differentiation in BMMSCs from normal controls , while addition of pyrollidine dithiocarbamate ( PDTC ) , an NF-?B inhibitor , to SLE-BMMSCs could partially reverse these effects . Negative_regulation SMAD2 ANGPT1 17085463 1685077 also *reduced* renal tissue levels of transforming growth factor-beta1 ( TGF-beta1 ) , alpha-smooth muscle actin , fibronectin , as well as [Smad 2/3] expression , but increased Smad 7 expression . Negative_regulation SMAD2 CTGF 15377500 1353934 The proinflammatory cytokines tumor necrosis factor-alpha and IL-1 beta reduced TGF-beta 1-stimulated mRNA expression of but did not *inhibit* TGF-beta induced [Smad2/3] phosphorylation . Negative_regulation SMAD2 EPHB2 15377500 1353925 Inhibition of and c-jun NH ( 2 ) -terminal kinase ( JNK ) , but not of p38 MAPK and PI3K , *blocked* the effect of TGF-beta 1 on CTGF mRNA and protein expression and on [Smad2/3] phosphorylation . Negative_regulation SMAD2 EPHB2 16135812 1450487 Pathway- and expression level dependent effects of oncogenic N-Ras : p27 ( Kip1 ) mislocalization by the Ral-GEF pathway and *mediated* interference with [Smad] signaling . Negative_regulation SMAD2 F2R 15522964 1367253 Moreover , activation of led to a profound and spread cytosolic clustering formation of Smad2/3 and markedly *prevented* [Smad2/3] nuclear translocation evoked by TGF-beta1 . Negative_regulation SMAD2 ID1 24434151 2912650 In addition , *inhibited* TGF-ß induced phosphorylation of [Smad2] and Smad3 . Negative_regulation SMAD2 TNF 10903323 730706 *inhibits* transforming growth factor-beta [/Smad] signaling in human dermal fibroblasts via AP-1 activation . Negative_regulation SMAD2 TNF 10903323 730714 In this report , we demonstrate that *prevents* TGF-beta induced [Smad-specific] gene transactivation without inducing detectable levels of inhibitory Smad7 in human dermal fibroblasts . Negative_regulation SMAD2 TNF 10903323 730722 Expression of antisense c-Jun mRNA prevents *inhibition* of [TGF-beta/Smad] signaling whereas that of dominant negative Ikappa-B kinase-alpha or antisense Smad7 does not . Negative_regulation SMAD2 TNF 10903323 730734 Finally , we show that overexpression of the transcriptional co-activator p300 prevents *inhibition* of [TGF-beta/Smad] signaling . Negative_regulation SMAD2 TNF 12426318 1036678 We demonstrate that , in a cellular context devoid of JNK activity ( i.e. jnk ( -/- ) fibroblasts ) , interleukin-1 and did not *inhibit* the formation of SMAD-DNA complexes and the resulting [SMAD-driven] transcription in response to TGF-beta . Negative_regulation SMAD2 TNF 17266397 1725629 In vitro , *suppresses* BMP-2- and TGFbeta mediated [Smad] activation through induction of NF-kappaB . Negative_regulation SMAD2 TNF 17266397 1725663 In vitro , potently *suppressed* [Smad] signaling induced by TGFbeta and BMP-2 , downregulated BMP-2 mediated Runx2 expression , and inhibited mineralization of osteoblasts . Negative_regulation SMAD3 ANGPT1 17085463 1685079 also *reduced* renal tissue levels of transforming growth factor-beta1 ( TGF-beta1 ) , alpha-smooth muscle actin , fibronectin , as well as [Smad 2/3] expression , but increased Smad 7 expression . Negative_regulation SMAD3 AXIN2 18172167 1855878 Reduction in the expression or activity of *leads* to increased [Smad3] stability and transcriptional activity without affecting TGF-beta receptors or Smad2 , whereas overexpression of these proteins promotes Smad3 basal degradation and desensitizes cells to TGF-beta . Negative_regulation SMAD3 CLU 22052058 2534070 *inhibited* TGF-ß stimulated [Smad3] activity via inhibition of Smad3 phosphorylation and its nuclear translocation . Negative_regulation SMAD3 CTGF 15377500 1353936 The proinflammatory cytokines tumor necrosis factor-alpha and IL-1 beta reduced TGF-beta 1-stimulated mRNA expression of but did not *inhibit* TGF-beta induced [Smad2/3] phosphorylation . Negative_regulation SMAD3 EPHB2 15377500 1353926 Inhibition of and c-jun NH ( 2 ) -terminal kinase ( JNK ) , but not of p38 MAPK and PI3K , *blocked* the effect of TGF-beta 1 on CTGF mRNA and protein expression and on [Smad2/3] phosphorylation . Negative_regulation SMAD3 EPHB2 16135812 1450488 Pathway- and expression level dependent effects of oncogenic N-Ras : p27 ( Kip1 ) mislocalization by the Ral-GEF pathway and *mediated* interference with [Smad] signaling . Negative_regulation SMAD3 EPHB2 16156666 1455583 We further show that mutation of the ERK phosphorylation sites increases the ability of Smad3 to stimulate a Smad target gene , suggesting that phosphorylation *inhibits* [Smad3] activity . Negative_regulation SMAD3 EPHB2 20060825 2218488 Halofuginone enhanced Akt , and p38 MAPK phosphorylation and *inhibited* [Smad3] phosphorylation in myotubes , all of which are crucial for myotube fusion . Negative_regulation SMAD3 EPHB2 22033246 2527438 Interestingly , EGF induced [smad3] phosphorylation was completely *blocked* by smad7 over-expression , but not the phosphorylation of and JNK . Negative_regulation SMAD3 F2R 15522964 1367254 Moreover , activation of led to a profound and spread cytosolic clustering formation of Smad2/3 and markedly *prevented* [Smad2/3] nuclear translocation evoked by TGF-beta1 . Negative_regulation SMAD3 HBEGF 23743191 2819977 Interestingly , did not *prevent* the TGF-ß induced nuclear accumulation of [Smad3] , but did lead to stabilization of the Smad transcriptional co-repressor TG-interacting factor . Negative_regulation SMAD3 ID1 24434151 2912651 In addition , *inhibited* TGF-ß induced phosphorylation of Smad2 and [Smad3] . Negative_regulation SMAD3 IL1B 21445336 2412254 *inhibited* phosphorylation of [Smad 3] and subsequently interfered with nuclear translocation of the positive Smad complex , thus occluding it off the gastrin promoter . Negative_regulation SMAD3 MAP2K6 12270924 1012559 Co-expression of Smad3 with constitutively active MKK3b and , the upstream activators of p38 , *resulted* in nuclear translocation of [Smad3] in the absence of TGF-beta and in induction of MMP-13 expression . Negative_regulation SMAD3 MAP2K6 17197157 1709415 Inhibition of ( MEK1 ) with either PD98059 or UO126 , however , *results* in a substantial dose dependent inhibition of [SMAD3] promoter activity . Negative_regulation SMAD3 TNF 10903323 730707 *inhibits* transforming growth factor-beta [/Smad] signaling in human dermal fibroblasts via AP-1 activation . Negative_regulation SMAD3 TNF 10903323 730715 In this report , we demonstrate that *prevents* TGF-beta induced [Smad-specific] gene transactivation without inducing detectable levels of inhibitory Smad7 in human dermal fibroblasts . Negative_regulation SMAD3 TNF 10903323 730723 Expression of antisense c-Jun mRNA prevents *inhibition* of [TGF-beta/Smad] signaling whereas that of dominant negative Ikappa-B kinase-alpha or antisense Smad7 does not . Negative_regulation SMAD3 TNF 10903323 730736 Finally , we show that overexpression of the transcriptional co-activator p300 prevents *inhibition* of [TGF-beta/Smad] signaling . Negative_regulation SMAD3 TNF 12426318 1036706 We demonstrate that , in a cellular context devoid of JNK activity ( i.e. jnk ( -/- ) fibroblasts ) , interleukin-1 and did not *inhibit* the formation of SMAD-DNA complexes and the resulting [SMAD-driven] transcription in response to TGF-beta . Negative_regulation SMAD3 TNF 17266397 1725630 In vitro , *suppresses* BMP-2- and TGFbeta mediated [Smad] activation through induction of NF-kappaB . Negative_regulation SMAD3 TNF 17266397 1725664 In vitro , potently *suppressed* [Smad] signaling induced by TGFbeta and BMP-2 , downregulated BMP-2 mediated Runx2 expression , and inhibited mineralization of osteoblasts . Negative_regulation SMAD4 EPHB2 16135812 1450489 Pathway- and expression level dependent effects of oncogenic N-Ras : p27 ( Kip1 ) mislocalization by the Ral-GEF pathway and *mediated* interference with [Smad] signaling . Negative_regulation SMAD4 TNF 10903323 730708 *inhibits* transforming growth factor-beta [/Smad] signaling in human dermal fibroblasts via AP-1 activation . Negative_regulation SMAD4 TNF 10903323 730716 In this report , we demonstrate that *prevents* TGF-beta induced [Smad-specific] gene transactivation without inducing detectable levels of inhibitory Smad7 in human dermal fibroblasts . Negative_regulation SMAD4 TNF 10903323 730724 Expression of antisense c-Jun mRNA prevents *inhibition* of [TGF-beta/Smad] signaling whereas that of dominant negative Ikappa-B kinase-alpha or antisense Smad7 does not . Negative_regulation SMAD4 TNF 10903323 730738 Finally , we show that overexpression of the transcriptional co-activator p300 prevents *inhibition* of [TGF-beta/Smad] signaling . Negative_regulation SMAD4 TNF 12426318 1036734 We demonstrate that , in a cellular context devoid of JNK activity ( i.e. jnk ( -/- ) fibroblasts ) , interleukin-1 and did not *inhibit* the formation of SMAD-DNA complexes and the resulting [SMAD-driven] transcription in response to TGF-beta . Negative_regulation SMAD4 TNF 17266397 1725631 In vitro , *suppresses* BMP-2- and TGFbeta mediated [Smad] activation through induction of NF-kappaB . Negative_regulation SMAD4 TNF 17266397 1725665 In vitro , potently *suppressed* [Smad] signaling induced by TGFbeta and BMP-2 , downregulated BMP-2 mediated Runx2 expression , and inhibited mineralization of osteoblasts . Negative_regulation SMAD5 EPHB2 16135812 1450490 Pathway- and expression level dependent effects of oncogenic N-Ras : p27 ( Kip1 ) mislocalization by the Ral-GEF pathway and *mediated* interference with [Smad] signaling . Negative_regulation SMAD5 TNF 10903323 730709 *inhibits* transforming growth factor-beta [/Smad] signaling in human dermal fibroblasts via AP-1 activation . Negative_regulation SMAD5 TNF 10903323 730717 In this report , we demonstrate that *prevents* TGF-beta induced [Smad-specific] gene transactivation without inducing detectable levels of inhibitory Smad7 in human dermal fibroblasts . Negative_regulation SMAD5 TNF 10903323 730725 Expression of antisense c-Jun mRNA prevents *inhibition* of [TGF-beta/Smad] signaling whereas that of dominant negative Ikappa-B kinase-alpha or antisense Smad7 does not . Negative_regulation SMAD5 TNF 10903323 730740 Finally , we show that overexpression of the transcriptional co-activator p300 prevents *inhibition* of [TGF-beta/Smad] signaling . Negative_regulation SMAD5 TNF 12426318 1036762 We demonstrate that , in a cellular context devoid of JNK activity ( i.e. jnk ( -/- ) fibroblasts ) , interleukin-1 and did not *inhibit* the formation of SMAD-DNA complexes and the resulting [SMAD-driven] transcription in response to TGF-beta . Negative_regulation SMAD5 TNF 17266397 1725632 In vitro , *suppresses* BMP-2- and TGFbeta mediated [Smad] activation through induction of NF-kappaB . Negative_regulation SMAD5 TNF 17266397 1725666 In vitro , potently *suppressed* [Smad] signaling induced by TGFbeta and BMP-2 , downregulated BMP-2 mediated Runx2 expression , and inhibited mineralization of osteoblasts . Negative_regulation SMAD5 TNF 22897816 2734830 activated NF-?B pathway and *inhibited* the phosphorylation of [Smad 1/5/8] and BMP-2 induced osteoblastic differentiation in BMMSCs from normal controls , while addition of pyrollidine dithiocarbamate ( PDTC ) , an NF-?B inhibitor , to SLE-BMMSCs could partially reverse these effects . Negative_regulation SMAD6 EPHB2 16135812 1450491 Pathway- and expression level dependent effects of oncogenic N-Ras : p27 ( Kip1 ) mislocalization by the Ral-GEF pathway and *mediated* interference with [Smad] signaling . Negative_regulation SMAD6 TNF 10903323 730710 *inhibits* transforming growth factor-beta [/Smad] signaling in human dermal fibroblasts via AP-1 activation . Negative_regulation SMAD6 TNF 10903323 730718 In this report , we demonstrate that *prevents* TGF-beta induced [Smad-specific] gene transactivation without inducing detectable levels of inhibitory Smad7 in human dermal fibroblasts . Negative_regulation SMAD6 TNF 10903323 730726 Expression of antisense c-Jun mRNA prevents *inhibition* of [TGF-beta/Smad] signaling whereas that of dominant negative Ikappa-B kinase-alpha or antisense Smad7 does not . Negative_regulation SMAD6 TNF 10903323 730742 Finally , we show that overexpression of the transcriptional co-activator p300 prevents *inhibition* of [TGF-beta/Smad] signaling . Negative_regulation SMAD6 TNF 12426318 1036790 We demonstrate that , in a cellular context devoid of JNK activity ( i.e. jnk ( -/- ) fibroblasts ) , interleukin-1 and did not *inhibit* the formation of SMAD-DNA complexes and the resulting [SMAD-driven] transcription in response to TGF-beta . Negative_regulation SMAD6 TNF 17266397 1725633 In vitro , *suppresses* BMP-2- and TGFbeta mediated [Smad] activation through induction of NF-kappaB . Negative_regulation SMAD6 TNF 17266397 1725667 In vitro , potently *suppressed* [Smad] signaling induced by TGFbeta and BMP-2 , downregulated BMP-2 mediated Runx2 expression , and inhibited mineralization of osteoblasts . Negative_regulation SMAD7 CTGF 15950619 1421502 Antisense oligonucleotides directed against TIEG-1 prevented *induced* downregulation of [Smad 7] . Negative_regulation SMAD7 CTGF 17403017 1728226 Additionally , IFN-gamma treatment stimulated [SMAD7] expression and *inhibited* , which has been considered a key molecule to promote the transdifferentiation of myofibroblasts via TGF-beta1 activation . Negative_regulation SMAD7 CTGF 17498122 1739838 Conversely , *reduced* [Smad7] , which was maximal at 24 hrs ( p < 0.05 ) . Negative_regulation SMAD7 EPHB2 16135812 1450492 Pathway- and expression level dependent effects of oncogenic N-Ras : p27 ( Kip1 ) mislocalization by the Ral-GEF pathway and *mediated* interference with [Smad] signaling . Negative_regulation SMAD7 TNF 10903323 730711 *inhibits* transforming growth factor-beta [/Smad] signaling in human dermal fibroblasts via AP-1 activation . Negative_regulation SMAD7 TNF 10903323 730719 In this report , we demonstrate that *prevents* TGF-beta induced [Smad-specific] gene transactivation without inducing detectable levels of inhibitory Smad7 in human dermal fibroblasts . Negative_regulation SMAD7 TNF 10903323 730727 Expression of antisense c-Jun mRNA prevents *inhibition* of [TGF-beta/Smad] signaling whereas that of dominant negative Ikappa-B kinase-alpha or antisense Smad7 does not . Negative_regulation SMAD7 TNF 10903323 730744 Finally , we show that overexpression of the transcriptional co-activator p300 prevents *inhibition* of [TGF-beta/Smad] signaling . Negative_regulation SMAD7 TNF 12426318 1036818 We demonstrate that , in a cellular context devoid of JNK activity ( i.e. jnk ( -/- ) fibroblasts ) , interleukin-1 and did not *inhibit* the formation of SMAD-DNA complexes and the resulting [SMAD-driven] transcription in response to TGF-beta . Negative_regulation SMAD7 TNF 17266397 1725634 In vitro , *suppresses* BMP-2- and TGFbeta mediated [Smad] activation through induction of NF-kappaB . Negative_regulation SMAD7 TNF 17266397 1725668 In vitro , potently *suppressed* [Smad] signaling induced by TGFbeta and BMP-2 , downregulated BMP-2 mediated Runx2 expression , and inhibited mineralization of osteoblasts . Negative_regulation SMAD7 TP63 19717565 2152079 *represses* transcription of the inhibitory [Smad7] and activates Bmp7 , thereby sustaining BMP signaling . Negative_regulation SMAD9 EPHB2 16135812 1450493 Pathway- and expression level dependent effects of oncogenic N-Ras : p27 ( Kip1 ) mislocalization by the Ral-GEF pathway and *mediated* interference with [Smad] signaling . Negative_regulation SMAD9 TNF 10903323 730712 *inhibits* transforming growth factor-beta [/Smad] signaling in human dermal fibroblasts via AP-1 activation . Negative_regulation SMAD9 TNF 10903323 730720 In this report , we demonstrate that *prevents* TGF-beta induced [Smad-specific] gene transactivation without inducing detectable levels of inhibitory Smad7 in human dermal fibroblasts . Negative_regulation SMAD9 TNF 10903323 730728 Expression of antisense c-Jun mRNA prevents *inhibition* of [TGF-beta/Smad] signaling whereas that of dominant negative Ikappa-B kinase-alpha or antisense Smad7 does not . Negative_regulation SMAD9 TNF 10903323 730746 Finally , we show that overexpression of the transcriptional co-activator p300 prevents *inhibition* of [TGF-beta/Smad] signaling . Negative_regulation SMAD9 TNF 12426318 1036846 We demonstrate that , in a cellular context devoid of JNK activity ( i.e. jnk ( -/- ) fibroblasts ) , interleukin-1 and did not *inhibit* the formation of SMAD-DNA complexes and the resulting [SMAD-driven] transcription in response to TGF-beta . Negative_regulation SMAD9 TNF 17266397 1725635 In vitro , *suppresses* BMP-2- and TGFbeta mediated [Smad] activation through induction of NF-kappaB . Negative_regulation SMAD9 TNF 17266397 1725669 In vitro , potently *suppressed* [Smad] signaling induced by TGFbeta and BMP-2 , downregulated BMP-2 mediated Runx2 expression , and inhibited mineralization of osteoblasts . Negative_regulation SMARCD3 EPHB2 24458360 2933087 In cultured myotubes , inhibition of , but not Jun NH2-terminal kinase and I?B kinase , *blocked* the downregulation of [Baf60c] and Deptor by the proinflammatory cytokine tumor necrosis factor-a . Negative_regulation SMC2 ANGPT1 17544375 1751900 Autologous secretion of by transduced EC *resulted* in Tie-2 activation and in the presence of [SMC] expressing VEGF resulted in coordinated sprouting in vitro and increase in flow and number of arteries in vivo . Negative_regulation SMC2 IL1B 19386793 2094854 Treatment of human PA-SMCs with roflumilast N-oxide , the active metabolite of roflumilast , at concentrations up to 10 ( -6 ) M , potentiated [PA-SMC] growth inhibition *induced* by prostacyclin ( 10 ( -6 ) M ) or ( 10 ng x ml(-1) ) but was inactive on its own . Negative_regulation SMC2 KLF9 15623517 1375679 Moreover , previous studies have demonstrated that the 4 potently *represses* the expression of multiple [SMC] genes . Negative_regulation SMC2 MMP28 9482695 487836 Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima , and inhibition of this *results* in reduced [SMC] migration and proliferation , suggesting a role for MMP-2 in neointimal development . Negative_regulation SMC2 MMP7 9482695 487851 Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima , and inhibition of this *results* in reduced [SMC] migration and proliferation , suggesting a role for MMP-2 in neointimal development . Negative_regulation SMC2 MSX1 17030628 1649062 Either or Msx2 markedly *reduced* the myocardin dependent promoter activities of [SMC] marker genes ( SM22alpha and caldesmon ) . Negative_regulation SMC2 TNFSF10 17322170 1719816 We conclude that produced by trophoblast causes apoptosis of SMC and thus may *contribute* to [SMC] loss during spiral artery remodeling in pregnancy . Negative_regulation SMC3 ANGPT1 17544375 1751904 Autologous secretion of by transduced EC *resulted* in Tie-2 activation and in the presence of [SMC] expressing VEGF resulted in coordinated sprouting in vitro and increase in flow and number of arteries in vivo . Negative_regulation SMC3 IL1B 19386793 2094858 Treatment of human PA-SMCs with roflumilast N-oxide , the active metabolite of roflumilast , at concentrations up to 10 ( -6 ) M , potentiated [PA-SMC] growth inhibition *induced* by prostacyclin ( 10 ( -6 ) M ) or ( 10 ng x ml(-1) ) but was inactive on its own . Negative_regulation SMC3 KLF9 15623517 1375747 Moreover , previous studies have demonstrated that the 4 potently *represses* the expression of multiple [SMC] genes . Negative_regulation SMC3 MMP28 9482695 487924 Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima , and inhibition of this *results* in reduced [SMC] migration and proliferation , suggesting a role for MMP-2 in neointimal development . Negative_regulation SMC3 MMP7 9482695 487939 Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima , and inhibition of this *results* in reduced [SMC] migration and proliferation , suggesting a role for MMP-2 in neointimal development . Negative_regulation SMC3 MSX1 17030628 1649070 Either or Msx2 markedly *reduced* the myocardin dependent promoter activities of [SMC] marker genes ( SM22alpha and caldesmon ) . Negative_regulation SMC3 TNFSF10 17322170 1719820 We conclude that produced by trophoblast causes apoptosis of SMC and thus may *contribute* to [SMC] loss during spiral artery remodeling in pregnancy . Negative_regulation SMC4 ANGPT1 17544375 1751901 Autologous secretion of by transduced EC *resulted* in Tie-2 activation and in the presence of [SMC] expressing VEGF resulted in coordinated sprouting in vitro and increase in flow and number of arteries in vivo . Negative_regulation SMC4 IL1B 19386793 2094855 Treatment of human PA-SMCs with roflumilast N-oxide , the active metabolite of roflumilast , at concentrations up to 10 ( -6 ) M , potentiated [PA-SMC] growth inhibition *induced* by prostacyclin ( 10 ( -6 ) M ) or ( 10 ng x ml(-1) ) but was inactive on its own . Negative_regulation SMC4 KLF9 15623517 1375696 Moreover , previous studies have demonstrated that the 4 potently *represses* the expression of multiple [SMC] genes . Negative_regulation SMC4 MMP28 9482695 487858 Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima , and inhibition of this *results* in reduced [SMC] migration and proliferation , suggesting a role for MMP-2 in neointimal development . Negative_regulation SMC4 MMP7 9482695 487873 Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima , and inhibition of this *results* in reduced [SMC] migration and proliferation , suggesting a role for MMP-2 in neointimal development . Negative_regulation SMC4 MSX1 17030628 1649064 Either or Msx2 markedly *reduced* the myocardin dependent promoter activities of [SMC] marker genes ( SM22alpha and caldesmon ) . Negative_regulation SMC4 TNFSF10 17322170 1719817 We conclude that produced by trophoblast causes apoptosis of SMC and thus may *contribute* to [SMC] loss during spiral artery remodeling in pregnancy . Negative_regulation SMC5 ANGPT1 17544375 1751902 Autologous secretion of by transduced EC *resulted* in Tie-2 activation and in the presence of [SMC] expressing VEGF resulted in coordinated sprouting in vitro and increase in flow and number of arteries in vivo . Negative_regulation SMC5 IL1B 19386793 2094856 Treatment of human PA-SMCs with roflumilast N-oxide , the active metabolite of roflumilast , at concentrations up to 10 ( -6 ) M , potentiated [PA-SMC] growth inhibition *induced* by prostacyclin ( 10 ( -6 ) M ) or ( 10 ng x ml(-1) ) but was inactive on its own . Negative_regulation SMC5 KLF9 15623517 1375713 Moreover , previous studies have demonstrated that the 4 potently *represses* the expression of multiple [SMC] genes . Negative_regulation SMC5 MMP28 9482695 487880 Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima , and inhibition of this *results* in reduced [SMC] migration and proliferation , suggesting a role for MMP-2 in neointimal development . Negative_regulation SMC5 MMP7 9482695 487895 Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima , and inhibition of this *results* in reduced [SMC] migration and proliferation , suggesting a role for MMP-2 in neointimal development . Negative_regulation SMC5 MSX1 17030628 1649066 Either or Msx2 markedly *reduced* the myocardin dependent promoter activities of [SMC] marker genes ( SM22alpha and caldesmon ) . Negative_regulation SMC5 TNFSF10 17322170 1719818 We conclude that produced by trophoblast causes apoptosis of SMC and thus may *contribute* to [SMC] loss during spiral artery remodeling in pregnancy . Negative_regulation SMC6 ANGPT1 17544375 1751903 Autologous secretion of by transduced EC *resulted* in Tie-2 activation and in the presence of [SMC] expressing VEGF resulted in coordinated sprouting in vitro and increase in flow and number of arteries in vivo . Negative_regulation SMC6 IL1B 19386793 2094857 Treatment of human PA-SMCs with roflumilast N-oxide , the active metabolite of roflumilast , at concentrations up to 10 ( -6 ) M , potentiated [PA-SMC] growth inhibition *induced* by prostacyclin ( 10 ( -6 ) M ) or ( 10 ng x ml(-1) ) but was inactive on its own . Negative_regulation SMC6 KLF9 15623517 1375730 Moreover , previous studies have demonstrated that the 4 potently *represses* the expression of multiple [SMC] genes . Negative_regulation SMC6 MMP28 9482695 487902 Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima , and inhibition of this *results* in reduced [SMC] migration and proliferation , suggesting a role for MMP-2 in neointimal development . Negative_regulation SMC6 MMP7 9482695 487917 Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima , and inhibition of this *results* in reduced [SMC] migration and proliferation , suggesting a role for MMP-2 in neointimal development . Negative_regulation SMC6 MSX1 17030628 1649068 Either or Msx2 markedly *reduced* the myocardin dependent promoter activities of [SMC] marker genes ( SM22alpha and caldesmon ) . Negative_regulation SMC6 TNFSF10 17322170 1719819 We conclude that produced by trophoblast causes apoptosis of SMC and thus may *contribute* to [SMC] loss during spiral artery remodeling in pregnancy . Negative_regulation SMN1 ANGPT1 19403408 2070399 can inhibit AngII induced activation of Rock2 and *reduce* [alpha-SMA] expression in HSCs . Negative_regulation SMN1 CTGF 16324366 1490939 The mRNA expression of the HKC cells transfected with CTGF ASODN that was stimulated by TGF-beta1 10 microg/L was significantly suppressed ( P < 0.01 ) and the [alpha-SMA] mRNA expression induced by TGF-beta1 10 microg/L was significantly *inhibited* by CTGF ASODN transfection ( P < 0.01 ) . Negative_regulation SMN1 EDN2 17250650 1732873 Transfection of active forms of RhoA and its effector , mDia , strongly enhanced [SMA] promoter activity , and a dominant negative form of RhoA *inhibited* stimulated promoter activity but not TGF-beta stimulated activity . Negative_regulation SMN1 EDN2 17250650 1732877 Whereas consistently activated RhoA , TGF-beta did not , and a specific inhibitor of TGF-beta type I receptor *blocked* TGF-beta enhanced [SMA] promoter activity , suggesting involvement of Smad phosphorylation . Negative_regulation SMN1 EPHB2 12842814 1149642 was not activated by force , but p38 phosphorylation was *required* for force induced inhibition of [SMA] expression . Negative_regulation SMN1 HBEGF 9697669 524696 also strongly *inhibited* the increased expression of [alpha-SMA] due to TGF-beta1 . Negative_regulation SMN1 IL1B 10572062 568668 *inhibits* [alpha-SMA] expression by inducing apoptosis selectively in myofibroblasts via induction of nitric oxide synthase ( inducible nitric oxide synthase [ iNOS ] ) . Negative_regulation SMN1 IL1B 10572062 568669 The results show that TGF-beta(1) caused a virtually complete suppression of induced iNOS expression while *preventing* the decline in [alpha-SMA] expression or the myofibroblast subpopulation . Negative_regulation SMN1 IL1B 15383601 1298979 The results showed that *inhibited* [alpha-SMA] expression in a dose dependent manner , which was associated with stimulation of the expression of both C/EBPbeta isoforms , liver enriched activating protein (LAP) and liver enriched inhibitory protein ( LIP ) . Negative_regulation SMN1 PLAU 23018346 2679395 Over-expression of Smad7 and *inhibited* the expression of [a-SMA] and TGF- ß1 significantly . Negative_regulation SMN1 RARB 12223147 987670 Transfection of RAR-beta gene and treatment with ligand ATRA could increase the expression of protein for at least 144h and *inhibit* the proliferation and the expression of [alpha-SMA] and desmin in PDGF activated HSC . Negative_regulation SMN1 SMN2 14749338 1226307 [SMA] *results* from loss of expression and subsequent death of motor neuron cells . Negative_regulation SMN1 SMN2 16580882 1574747 [SMA] is *caused* by the loss of . Negative_regulation SMN1 SMN2 16951947 1639498 [SMA] is *caused* by the homozygous absence of . Negative_regulation SMN1 SMN2 17401408 1721251 Reduced levels of expression *cause* the inherited motor neuron disease [spinal muscular atrophy (SMA)] . Negative_regulation SMN1 SMN2 17551501 1773647 [Spinal muscular atrophy (SMA)] is *caused* by loss of . Negative_regulation SMN1 SMN2 17561409 1774043 [SMA] *results* from the reduction of ( survival motor neuron) protein . Negative_regulation SMN1 SMN2 18971205 2014842 [Spinal muscular atrophy (SMA)] , a common neuromuscular disorder , is *caused* by homozygous absence of the , while the disease severity is mainly influenced by the number of SMN2 gene copies . Negative_regulation SMN1 SMN2 19074460 2035652 [SMA] is *caused* by loss of functional , resulting in death of spinal motor neurons . Negative_regulation SMN1 SMN2 19848583 2009273 [SMA] is *caused* by the loss of . Negative_regulation SMN1 SMN2 20053895 2193640 [SMA] is *caused* by the loss of , however , all patients retain at least one copy of a nearly identical gene called SMN2 . Negative_regulation SMN1 SMN2 20089893 2201314 Low levels of *result* in [spinal muscular atrophy (SMA)] , a severe genetic disease characterized by motor impairment and premature lethality . Negative_regulation SMN1 SMN2 20097677 2226193 [SMA] is *caused* by functional loss of the , whereas disease severity is mainly influenced by the number of SMN2 copies . Negative_regulation SMN1 SMN2 20188701 2229167 Childhood [spinal muscular atrophy (SMA)] is *caused* by a reduction in . Negative_regulation SMN1 SMN2 20515655 2284109 Childhood [spinal muscular atrophy (SMA)] is *caused* by a reduction in . Negative_regulation SMN1 SMN2 21546251 2435349 [Spinal muscular atrophy (SMA)] is *caused* by loss or mutations of the . Negative_regulation SMN1 SMN2 21672919 2465130 [Spinal muscular atrophy (SMA)] is *caused* by loss of the and retention of the SMN2 gene , resulting in reduced SMN . Negative_regulation SMN1 SMN2 22029744 2562555 [SMA] is *caused* by the homozygous loss of . Negative_regulation SMN1 SMN2 22079083 2562652 [SMA] is *caused* by the homozygous loss of . Negative_regulation SMN1 SMN2 22172949 2536765 [SMA] is *caused* by the homozygous loss of . Negative_regulation SMN1 SMN2 22172949 2536772 [SMA] , however , is not *due* to complete absence of , rather a low level of functional full-length SMN is produced by a nearly identical copy gene called SMN2 . Negative_regulation SMN1 SMN2 22324632 2576111 At present , the *role* of in [SMA] is unknown . Negative_regulation SMN1 SMN2 23390132 2759195 [Spinal Muscular Atrophy (SMA)] is *due* to the loss of the , resulting in motor neuron ( MN ) degeneration , muscle atrophy and loss of motor function . Negative_regulation SMN1 SMN2 23512182 2843496 [SMA] is *caused* by the homozygous loss of . Negative_regulation SMN1 SMN2 23656793 2823260 The loss of functional due to mutations or deletion in the SMN1 gene *causes* autosomal recessive neurodegenerative [spinal muscle atrophy (SMA)] . Negative_regulation SMN2 CPOX 15555999 1340122 Indoprofen , a nonsteroidal anti-inflammatory drug ( NSAID ) and inhibitor , selectively *increased* SMN2-luciferase reporter protein and endogenous [SMN] protein and caused a 5-fold increase in the number of nuclear gems in fibroblasts from SMA patients . Negative_regulation SMN2 CREB1 14742439 1226158 Transient overexpression of protein *resulted* in a 4-fold increase of the [SMN] promoter activity . Negative_regulation SMN2 CRK 10446344 636560 also *caused* an increase in the number of surviving [spinal motor neurons (SMN)] , and interestingly , upon staining of sternomastoid muscle fibers with rhodamine conjugated alpha-bungarotoxin , many muscle fibers displayed an apparent increase in volume of motor end plates , and an increase in complexity of neuromuscular junctions ( NMJ ) . Negative_regulation SMN2 DCPS 23727836 2843804 Quinazolines increase [SMN2] promoter activity and *inhibit* the ribonucleic acid scavenger enzyme . Negative_regulation SMN2 GYPB 22669476 2686845 SMA is caused by low levels of [survival motor neuron (SMN) protein] that *induce* selective loss of in the spinal cord , resulting in progressive muscle atrophy and consequent respiratory failure . Negative_regulation SMN2 NPY4R 22454514 2637027 A *role* for protein phosphatase in [SMN complex] formation and subnuclear localization to Cajal bodies . Negative_regulation SMN2 NPY4R 22454514 2637053 Moreover , depletion of by RNA interference *enhances* the localization of the [SMN complex] and snRNPs to CBs . Negative_regulation SMN2 NPY4R 22454514 2637082 Our findings reveal a *role* of in the formation of the [SMN complex] and the maintenance of CB integrity . Negative_regulation SMN2 PRNP 18178576 1889951 The *results* in high levels of [SMN] in neurons at embryonic day 15 . Negative_regulation SMN2 SMN1 19945425 2198948 is the *result* of reduction in [Survival Motor Neuron (SMN)] expression . Negative_regulation SMN2 SMN1 21118896 2377609 Loss of *leads* to reduced [SMN] protein levels , inducing degeneration of motor neurons ( MN ) and progressive muscle weakness and atrophy . Negative_regulation SMN2 SOD1 19332122 2074226 Furthermore , ALS linked mutant expression severely *reduced* [SMN] protein levels , but not transcript , in neuronal culture and mouse models from early presymptomatic disease . Negative_regulation SMN2 UCHL1 20713032 2330127 Over-expression of in P19 and NSC34 cells significantly *reduced* the level of [SMN] proteins in vivo , and , in fact , purified UCHL1 was shown to be able to enhance , in a dose dependent manner , the level of ubiquitinated SMN in vitro . Negative_regulation SMN2 UCHL1 20713032 2330143 Further , inhibition of activity by UCHL1 inhibitor ( LDN-57444 ) *increased* cellular [SMN] protein and gems number in the nucleus in NSC34 and SMA skin fibroblasts . Negative_regulation SMN2 WRAP53 21072240 2345085 Furthermore , depletion of *leads* to accumulation of [SMN] in the cytoplasm and prevents the SMN complex from reaching Cajal bodies . Negative_regulation SMN2 ZNF259 11283611 799460 Similarly , decreased expression *prevents* [SMN] localization to nuclear bodies . Negative_regulation SMN2 ZNF259 15767679 1384222 Together , these data indicate that *contributes* to the regulation of [SMN] complexes and that it is essential for cell survival . Negative_regulation SMPD2 TNF 11311151 804927 Interestingly , stimulation of fibroblasts with *resulted* in a partial shift of its p55 receptor to caveolin enriched membrane fractions and the appearance of caveolin-sensitive [neutral sphingomyelinase] activity in the non-caveolar fractions . Negative_regulation SNAI1 VSNL1 22479362 2578857 [Snail1] expression is *reduced* by ectopic in VILIP-1 negative SCC cells , and application of the general adenylyl cyclase inhibitor 2',3'-dideoxyadenosine attenuated this effect . Negative_regulation SNAP25 RIC3 18591430 1931355 However , [RIC4] overexpression inhibited exocytosis , and this inhibition could be *suppressed* by latrunculin B treatment or overexpression . Negative_regulation SNCA PTGER2 17204153 1681257 We investigated the *role* of prostaglandin in [alpha-synuclein] aggregation induced microglial activation using ex vivo , in vivo and in vitro experimental systems . Negative_regulation SNCA SNCAIP 21103907 2447443 *inhibits* [alpha-synuclein] degradation by the proteasome . Negative_regulation SNCA TNF 18501880 1928144 inversely *reduced* [alpha-synuclein] and increased ubiquitin content . Negative_regulation SNCAIP LPA 9030602 414715 This specific [Sph-1-P] binding was *inhibited* not by other sphingolipids but by , and platelet aggregation response to LPA was specifically desensitized by prior addition of Sph-1-P . Negative_regulation SNORD71 EPHB2 23770856 2932336 *Repression* of [microRNA-768-3p] by signalling contributes to enhanced mRNA translation in human melanoma . Negative_regulation SNORD71 MAP2K6 23770856 2932342 *Repression* of [microRNA-768-3p] by signalling contributes to enhanced mRNA translation in human melanoma . Negative_regulation SNRNP70 TNF 10022522 590100 , which enhances the posttranscriptional action of retinoic acid , *reduced* [U1 70K] mRNA expression , while an inhibition of retinoic acid action by transforming growth factor-beta was associated with a marked increase in U1 70K mRNA levels . Negative_regulation SNRPN TNF 11009425 735904 In differentiating C2C12 myocytes , induced activation of NF-kappaB *inhibited* [SMD] by suppressing MyoD mRNA at the posttranscriptional level . Negative_regulation SOAT1 EPHB2 11331873 808923 A tyrosine mutant of SOCS-3 still blocks [STAT] phosphorylation , but also strongly *inhibits* IL-2 dependent activation of and cell proliferation . Negative_regulation SOAT1 EPHB2 16686690 1560218 These data suggest that the cascade functions downstream of Rac GTPase to actively *repress* pro-apoptotic [JAK/STAT] signaling in healthy CGNs . Negative_regulation SOAT1 EPHB2 9736697 531351 These results demonstrate an *mediated* mechanism for inhibiting IL-6 induced [Jak-STAT] signaling that is rapid and inducible , and thus differs from previously described mechanisms for downmodulation of the Jak-STAT pathway . Negative_regulation SOAT1 FHL1 15963787 1423176 Overexpression of SLIM leads to impaired STAT1 and STAT4 activity due to reduced STAT protein levels , while *results* in increased [STAT] expression and thus enhanced IFNgamma production by Th1 cells . Negative_regulation SOAT1 MAP2K6 16686690 1560224 These data suggest that the cascade functions downstream of Rac GTPase to actively *repress* pro-apoptotic [JAK/STAT] signaling in healthy CGNs . Negative_regulation SOAT1 TLR7 24251781 2903367 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , PI3K/AkT inhibition , IKK/JNK inhibition , mTORC1 inhibition , [JAK/STAT] *inhibition* , suppression , and ACE inhibition . Negative_regulation SOCS3 IL1B 15893771 1419777 At 200 ng/ml TNFalpha , [SOCS3] mRNA levels were increased , but significantly *reduced* in the presence of or IL-6 ( P < 0.05 ) . Negative_regulation SOCS3 TNF 23335796 2753614 Downregulation of [SOCS3] in the *presence* of both and IGF-1 in hCASMCs is due to SOCS3 promoter hypermethylation involving STAT3-NFkBp65 interaction . Negative_regulation SOD1 ARSA 12774247 1095269 ASA also enhanced significantly the mucosal MDA content and downregulated [SOD] and GPx mRNA , and these effects were markedly *reduced* by . Negative_regulation SOD1 IL1B 10076538 560588 EA inhibited RINm5F cell [Cu/Zn-SOD] in the *presence* and absence of , whereas EA-S increased basal enzyme activity and did not affect the IL-1 beta response . Negative_regulation SOD1 IL1B 10076538 560591 EA did not affect basal [Mn-SOD] activity and *inhibited* stimulated activity , whereas EA-S was without effect . Negative_regulation SOD1 TNF 1568640 186989 These facts suggest that secretion from the infarcted area *resulted* in the production of [Mn-SOD] and that the induced Mn-SOD was released from myocytes into serum through damaged membranes , resulting in the late elevation . Negative_regulation SOD1 TNF 16895791 1597327 A JNK inhibitor antagonized the negative effects of TNF-alpha on SOD1 promoter activity , suggesting that JNK signaling through c-Jun protein activation is critical for the *dependent* [SOD1] repression . Negative_regulation SOD1 TNF 16895791 1597329 A greater understanding of the mechanisms of *induced* [SOD1] repression could facilitate the design and development of novel therapeutic drugs for inflammatory conditions . Negative_regulation SOD1 TNF 7946385 276722 Although Mn [SOD] was low in BEAS 2B cells , it could be significantly *induced* by treatment . Negative_regulation SOD2 ALOX5 24226420 2926620 Similar to 5-LO ( -/- ) mice , induction of HO-1 , but not [superoxide dismutase-2 (SOD-2)] , was also observed in *response* to <5-LO> ( AA861 ) or 5-LO activating protein ( MK886 ) inhibitors . Negative_regulation SOD2 ARSA 12774247 1095270 ASA also enhanced significantly the mucosal MDA content and downregulated [SOD] and GPx mRNA , and these effects were markedly *reduced* by . Negative_regulation SOD2 IL1B 10076538 560589 EA inhibited RINm5F cell [Cu/Zn-SOD] in the *presence* and absence of , whereas EA-S increased basal enzyme activity and did not affect the IL-1 beta response . Negative_regulation SOD2 IL1B 10076538 560592 EA did not affect basal [Mn-SOD] activity and *inhibited* stimulated activity , whereas EA-S was without effect . Negative_regulation SOD2 TNF 1568640 186990 These facts suggest that secretion from the infarcted area *resulted* in the production of [Mn-SOD] and that the induced Mn-SOD was released from myocytes into serum through damaged membranes , resulting in the late elevation . Negative_regulation SOD2 TNF 7946385 276723 Although Mn [SOD] was low in BEAS 2B cells , it could be significantly *induced* by treatment . Negative_regulation SOD3 ARSA 12774247 1095271 ASA also enhanced significantly the mucosal MDA content and downregulated [SOD] and GPx mRNA , and these effects were markedly *reduced* by . Negative_regulation SOD3 IL1B 10076538 560590 EA inhibited RINm5F cell [Cu/Zn-SOD] in the *presence* and absence of , whereas EA-S increased basal enzyme activity and did not affect the IL-1 beta response . Negative_regulation SOD3 IL1B 10076538 560593 EA did not affect basal [Mn-SOD] activity and *inhibited* stimulated activity , whereas EA-S was without effect . Negative_regulation SOD3 TNF 1568640 186991 These facts suggest that secretion from the infarcted area *resulted* in the production of [Mn-SOD] and that the induced Mn-SOD was released from myocytes into serum through damaged membranes , resulting in the late elevation . Negative_regulation SOD3 TNF 7946385 276724 Although Mn [SOD] was low in BEAS 2B cells , it could be significantly *induced* by treatment . Negative_regulation SOS1 EPHB2 10537288 563187 Activation of by GnRHa occurred within 5 min , with the maximum occurring at 3 h and sustained until 24 h. GnRHa also activated ERK kinase ( mitogen activated protein/ERK kinase ) and *resulted* in an increase in phosphorylation of [son of sevenless (Sos)] , and Shc . Negative_regulation SOS1 EPHB2 20724475 2330214 Here , we used a simulation model based mostly on experimentally determined parameters to study the *mediated* negative feedback regulation of the Ras guanine nucleotide exchange factor , [son of sevenless (SOS)] . Negative_regulation SOS1 MAP2K6 8552085 347120 Expression of a dominant interfering mutant , in which lysine 97 was replaced with arginine ( MEK/K97R ) , resulted in an *inhibition* of insulin stimulated [SOS] and ERK phosphorylation , whereas expression of a constitutively active MEK mutant , in which serines 218 and 222 were replaced with glutamic acid ( MEK/EE ) , induced basal phosphorylation of both SOS and ERK . Negative_regulation SOS2 EPHB2 10537288 563188 Activation of by GnRHa occurred within 5 min , with the maximum occurring at 3 h and sustained until 24 h. GnRHa also activated ERK kinase ( mitogen activated protein/ERK kinase ) and *resulted* in an increase in phosphorylation of [son of sevenless (Sos)] , and Shc . Negative_regulation SOS2 EPHB2 20724475 2330215 Here , we used a simulation model based mostly on experimentally determined parameters to study the *mediated* negative feedback regulation of the Ras guanine nucleotide exchange factor , [son of sevenless (SOS)] . Negative_regulation SOS2 MAP2K6 8552085 347127 Expression of a dominant interfering mutant , in which lysine 97 was replaced with arginine ( MEK/K97R ) , *resulted* in an inhibition of insulin stimulated [SOS] and ERK phosphorylation , whereas expression of a constitutively active MEK mutant , in which serines 218 and 222 were replaced with glutamic acid ( MEK/EE ) , induced basal phosphorylation of both SOS and ERK . Negative_regulation SOST EPHB2 23362266 2758757 [Sost] down-regulation by strain or ERß activation is *prevented* by blockade . Negative_regulation SOST MAP2K6 23362266 2758763 [Sost] down-regulation by strain or ERß activation is *prevented* by blockade . Negative_regulation SOX11 CCND1 22827557 2682278 [SOX11] expression of very low levels close to the assay sensitivity was *detected* in only 2 of 18 healthy donors , while low levels of expression was observed in all blood and 12 of 13 marrow samples within the defined detection limit of Cq = 40 . Negative_regulation SOX9 IL1B 15961395 1440759 Inhibition of c-Jun N-terminal kinase or AP-1 reversed *induced* suppression of [Sox-9] , and ectopic expression of c-Jun was sufficient to cause suppression of Sox-9 . Negative_regulation SOX9 MAP2K6 19762915 2158829 CA Akt also promoted type II collagen and Sox9 expression , whereas tBHP treatment and CA *inhibited* aggrecan , collagen II , and [Sox9] mRNA expression . Negative_regulation SP1 EPHB2 18239466 1890512 PKC , , and ERBB2 kinase inhibitors *suppress* PMA induction of [Sp1] and the specific isozyme PKCalpha enhances Sp1 cleavage . Negative_regulation SP1 EPHB2 20121399 2206933 In primary monocytes , and p38 inhibition *increased* binding of AP-1 and [Sp1] , respectively , to the IL-12p40 promoter , while JNK inhibition increased NF-kappaB , AP-1 , and Sp1 binding . Negative_regulation SP1 IL1B 17892496 1802592 The inhibition was exerted at the level of the transcription factors Sp1 and nuclear-kappaB : ( a ) *inhibited* the glutamine stimulated DNA binding of [Sp1] , which might be related to a decrease of its glutamine induced O-glycosylation , and ( b ) glutamine induced per se a decrease in the amount of nuclear p65 protein without affecting the stimulating effect of interleukin-1beta on nuclear factor-kappaB , which might be related to the metabolism of glutamine into glutamate . Negative_regulation SP1 MMP28 20488920 2288771 CDDO-Me also induced reactive oxygen species ( ROS ) and decreased mitochondrial membrane potential (MMP) in Panc1 and L3.6pL cells , and cotreatment with antioxidants ( glutathione and dithiothreitol ) blocked the formation of ROS , reversed the loss of , and *inhibited* down-regulation of [Sp1] , Sp3 , and Sp4 . Negative_regulation SP1 MMP7 20488920 2288786 CDDO-Me also induced reactive oxygen species ( ROS ) and decreased mitochondrial membrane potential (MMP) in Panc1 and L3.6pL cells , and cotreatment with antioxidants ( glutathione and dithiothreitol ) blocked the formation of ROS , reversed the loss of , and *inhibited* down-regulation of [Sp1] , Sp3 , and Sp4 . Negative_regulation SP1 TNF 11897710 921611 While ( 5 ng/ml ) *blocked* insulin stimulated [Sp1] , it failed to block stimulation of Sp1 by glucagon ( 1.5 x 10 ( -5 ) M ) . Negative_regulation SP1 TNF 16895791 1597325 In agreement with these findings , EMSA shows a *induced* increase in AP-1 and a decrease in [Sp1] DNA binding . Negative_regulation SP1 TNF 21784970 2484593 *inhibited* TTF-1 but not [Sp1] or hepatocyte nuclear factor-3 DNA binding to TTF-1 promoter . Negative_regulation SP1 TNF 21784970 2484595 Transactivation experiments in A549 cells indicated that *inhibited* TTF-1 promoter activation by exogenous [Sp1] and TTF-1 without altering their levels , suggesting inhibition of transcriptional activities of these proteins . Negative_regulation SPAG11B IL1B 15833737 1417991 Calu-3 expresses EP4 receptors , but not [EP2] , and receptor expression is *reduced* by . Negative_regulation SPAG11B PTGER2 16666972 126579 is inhibited by phenylmethylsulfonylfluoride , and both [EP2] and EP3 are *inhibited* by the heavy metal chelators 1,10-phenanthroline and EDTA . Negative_regulation SPAG11B RORC 24812667 2939861 In Th17 cells isolated from humans , *repressed* [EP2] by directly silencing PTGER2 transcription , and knock down of RORC restored EP2 expression in Th17 cells . Negative_regulation SPAG8 IFI27 22692684 2638666 Furthermore , siRNA mediated Ifi202b suppression in 3T3-L1 adipocytes resulted in a significant inhibition of 11ß-Hsd1 expression , whereas an adenoviral mediated overexpression of *increased* [11ß-Hsd1] mRNA levels . Negative_regulation SPARC EPHB2 24253315 2898101 In addition , miR-29b is upregulated following ERK inhibition , suggesting a Snail dependent pathway by which Snail activation of TGF-ß and signaling *results* in downregulation of miR-29b and subsequent upregulation of [SPARC] . Negative_regulation SPARC IL1B 19136283 2079114 However , only TNFalpha inhibited [osteonectin] and osteopontin mRNA expression and only *reduced* cell proliferation . Negative_regulation SPARC IL1B 8630101 361142 TGF beta increased SPARC messenger RNA ( mRNA ) levels at 24 hours , whereas *caused* a marked decrease in [SPARC] mRNA levels at 24 hours . Negative_regulation SPARC TNF 19136283 2079113 However , only *inhibited* [osteonectin] and osteopontin mRNA expression and only IL-1beta reduced cell proliferation . Negative_regulation SPARC TNFSF10 16622457 1556729 Moreover , the expression of MMP-2 , its inhibitor TIMP-2 and the tumour invasiveness related protein [SPARC] were effectively *inhibited* by in glioblastoma cell lines . Negative_regulation SPAST JAG1 18495362 1921849 However , contrary to Taxol , *induced* downregulation of the microtubule severing protein [Spastin] . Negative_regulation SPDEF TLR7 23012424 2684426 Here , we demonstrate that [SAM pointed domain ETS factor (SPDEF)] was induced by rhinoviral infection of primary human airway cells and that cytoplasmic activities of SPDEF , a transcriptional regulator of airway goblet cell metaplasia , *inhibited* activation of epithelial cells . Negative_regulation SPHK1 AKT1 15993704 1429701 Inhibition of SPHK-1 also did not affect EGF stimulated phosphorylation of PI-3 kinase , , ERK1/2 or p38 but inhibition of PI-3 kinase with a specific inhibitor LY294002 partly ( 40 % ) *inhibited* the EGF stimulated increase in [SPHK-1] activity . Negative_regulation SPHK1 AKT2 15993704 1429702 Inhibition of SPHK-1 also did not affect EGF stimulated phosphorylation of PI-3 kinase , , ERK1/2 or p38 but inhibition of PI-3 kinase with a specific inhibitor LY294002 partly ( 40 % ) *inhibited* the EGF stimulated increase in [SPHK-1] activity . Negative_regulation SPHK1 AKT3 15993704 1429703 Inhibition of SPHK-1 also did not affect EGF stimulated phosphorylation of PI-3 kinase , , ERK1/2 or p38 but inhibition of PI-3 kinase with a specific inhibitor LY294002 partly ( 40 % ) *inhibited* the EGF stimulated increase in [SPHK-1] activity . Negative_regulation SPHK1 BCL2 15637591 1362799 Importantly , overexpression of the prosurvival protein in A-375 cells markedly *stimulated* [SphK1] expression and activity , while downregulation of Bcl-2 reduced SphK1 expression . Negative_regulation SPHK1 CASP1 16890416 1607649 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating [sphingosine kinase] and *inhibiting* activity . Negative_regulation SPHK1 CASP10 16890416 1607650 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating [sphingosine kinase] and *inhibiting* activity . Negative_regulation SPHK1 CASP12 16890416 1607660 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating [sphingosine kinase] and *inhibiting* activity . Negative_regulation SPHK1 CASP14 16890416 1607651 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating [sphingosine kinase] and *inhibiting* activity . Negative_regulation SPHK1 CASP16 16890416 1607661 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating [sphingosine kinase] and *inhibiting* activity . Negative_regulation SPHK1 CASP2 16890416 1607652 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating [sphingosine kinase] and *inhibiting* activity . Negative_regulation SPHK1 CASP3 16890416 1607653 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating [sphingosine kinase] and *inhibiting* activity . Negative_regulation SPHK1 CASP4 16890416 1607654 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating [sphingosine kinase] and *inhibiting* activity . Negative_regulation SPHK1 CASP5 16890416 1607655 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating [sphingosine kinase] and *inhibiting* activity . Negative_regulation SPHK1 CASP6 16890416 1607656 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating [sphingosine kinase] and *inhibiting* activity . Negative_regulation SPHK1 CASP7 16890416 1607657 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating [sphingosine kinase] and *inhibiting* activity . Negative_regulation SPHK1 CASP8 16890416 1607658 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating [sphingosine kinase] and *inhibiting* activity . Negative_regulation SPHK1 CASP9 16890416 1607659 Prostaglandin E2 ( PGE2 ) increases the number of rat bone marrow osteogenic stromal cells ( BMSC ) via binding the EP4 receptor , activating [sphingosine kinase] and *inhibiting* activity . Negative_regulation SPHK1 CD82 18622748 1936375 Ablation of Sprouty2 with RNA interference can block the *induced* suppression of hepatoma cell migration and downregulation of [SphK1] expression . Negative_regulation SPHK1 CNR2 20718749 2306755 In addition to this , S1P mediated relaxation was also reduced by receptor antagonists and [sphingosine kinase] *inhibition* . Negative_regulation SPHK1 DHPS 15881228 1406420 Interestingly , , an *inhibitor* of [sphingosine kinase] , clearly blocked the ceramide analogue induced stimulation . Negative_regulation SPHK1 DHPS 15927078 1420646 The initial phase of constriction was nearly absent in peripheral airways of M3R-KO mice when [SPHK] was *inhibited* by and DMS but was unaffected in M2R-KO mice . Negative_regulation SPHK1 DHPS 9099730 422814 We report herein that , a competitive *inhibitor* of [sphingosine kinase] that prevents PDGF induced SPP formation , specifically inhibited the activation of two cyclin dependent kinases ( p34 ( cdc2 ) kinase and Cdk2 kinase ) induced by PDGF , but not by EGF . Negative_regulation SPHK1 GRAP2 15993704 1429704 Inhibition of SPHK-1 also did not affect EGF stimulated phosphorylation of PI-3 kinase , Akt , ERK1/2 or but inhibition of PI-3 kinase with a specific inhibitor LY294002 partly ( 40 % ) *inhibited* the EGF stimulated increase in [SPHK-1] activity . Negative_regulation SPHK1 IL6 17686057 1781499 stimulation or retroviral mediated overexpression of SPHK1 in MM cells *resulted* in increased intracellular [SPHK] activity and upregulation of myeloid cell leukaemia-1 (Mcl-1) , leading to increased cell proliferation and survival . Negative_regulation SPHK1 JUN 19074142 2030483 The IL-1 induced [SphK1] up-regulation can be *blocked* by the inhibition of JNK , the overexpression of the dominant negative ( TAM67 ) , and the down-regulation of c-Jun expression by small interference RNA . Negative_regulation SPHK1 LPA 18701480 1950418 transactivated the epidermal growth factor receptor (EGFR) in these cells , and the EGFR inhibitor AG1478 *attenuated* the increased [SphK1] and S1P(3) expression induced by LPA . Negative_regulation SPHK1 MAP2K1 15242760 1270683 This effect was inhibited by mitogen activated protein ERK kinase ( ) and [sphingosine kinase (SK)] *inhibitors* , indicating that prosaposin prevents cell apoptosis by activation of extracellular signal regulated kinases ( ERKs ) and sphingosine kinase . Negative_regulation SPHK1 MAP2K2 15242760 1270684 This effect was inhibited by mitogen activated protein ERK kinase ( ) and [sphingosine kinase (SK)] *inhibitors* , indicating that prosaposin prevents cell apoptosis by activation of extracellular signal regulated kinases ( ERKs ) and sphingosine kinase . Negative_regulation SPHK1 MAP2K3 15242760 1270685 This effect was inhibited by mitogen activated protein ERK kinase ( ) and [sphingosine kinase (SK)] *inhibitors* , indicating that prosaposin prevents cell apoptosis by activation of extracellular signal regulated kinases ( ERKs ) and sphingosine kinase . Negative_regulation SPHK1 MAP2K4 15242760 1270686 This effect was inhibited by mitogen activated protein ERK kinase ( ) and [sphingosine kinase (SK)] *inhibitors* , indicating that prosaposin prevents cell apoptosis by activation of extracellular signal regulated kinases ( ERKs ) and sphingosine kinase . Negative_regulation SPHK1 MAP2K5 15242760 1270687 This effect was inhibited by mitogen activated protein ERK kinase ( ) and [sphingosine kinase (SK)] *inhibitors* , indicating that prosaposin prevents cell apoptosis by activation of extracellular signal regulated kinases ( ERKs ) and sphingosine kinase . Negative_regulation SPHK1 MAP2K6 15242760 1270688 This effect was inhibited by mitogen activated protein ERK kinase ( ) and [sphingosine kinase (SK)] *inhibitors* , indicating that prosaposin prevents cell apoptosis by activation of extracellular signal regulated kinases ( ERKs ) and sphingosine kinase . Negative_regulation SPHK1 MAP2K7 15242760 1270689 This effect was inhibited by mitogen activated protein ERK kinase ( ) and [sphingosine kinase (SK)] *inhibitors* , indicating that prosaposin prevents cell apoptosis by activation of extracellular signal regulated kinases ( ERKs ) and sphingosine kinase . Negative_regulation SPHK1 MAPK3 15993704 1429705 Inhibition of SPHK-1 also did not affect EGF stimulated phosphorylation of PI-3 kinase , Akt , or p38 but inhibition of PI-3 kinase with a specific inhibitor LY294002 partly ( 40 % ) *inhibited* the EGF stimulated increase in [SPHK-1] activity . Negative_regulation SPHK1 MAPK3 17388800 1720883 Blocking signaling *caused* the loss of [SphK] activation and VEGF and IGF-I up-regulation . Negative_regulation SPHK1 MMP14 17388800 1720858 Decreasing [SphK1] expression by small interfering RNA ( siRNA ) , blocked IGFBP-3 induced network formation and *inhibited* VEGF , but not IGF-I up-regulation . Negative_regulation SPHK1 MYB 23328083 2758324 c-MYB overexpression and siRNA for c-Myb affected SPHK1 expression , confirming the important regulatory *role* of in [SPHK1] expression . Negative_regulation SPHK1 MYLIP 24257299 2869503 Western blot showed that the expression of [SPHK1] protein was *inhibited* by . Negative_regulation SPHK1 NRAS 23545258 2777735 Given the up-regulated expression of [SphK1] in *response* to the silence of and other interactions between Ras/ERK and SphK1 , it was speculated that combined inhibition of Ras/ERK and SphK1 would create enhanced antitumor effects . Negative_regulation SPHK1 PAPSS1 19723667 2133935 In the present study , we found that a potent isotype-specific [SphK1] *inhibitor* , , suppressed growth of LN229 and U373 glioblastoma cell lines and nonestablished human GBM6 cells . Negative_regulation SPHK1 PAPSS1 22939756 2734890 We used an isoenzyme-specific [SphK1] *inhibitor* , , to investigate the contributions of S1P and SphK1 to mast cell dependent airway hyperresponsiveness (AHR) and airway inflammation in mice . Negative_regulation SPHK1 SKI 21321095 2420140 We found that the [Sphk1/2] selective *inhibitor* ( ) -II , blocked breast cancer viability , clonogenic survival and proliferation . Negative_regulation SPHK1 SKI 22859737 2640953 Two [sphingosine kinase] *inhibitors* , and ABC294640 , are promising as potential breast cancer therapies . Negative_regulation SPHK1 SKIV2L 17879964 1802331 Sphingolipids and the [sphingosine kinase] *inhibitor* , , induce BCL-2 independent apoptosis in human prostatic adenocarcinoma cells . Negative_regulation SPHK1 SKIV2L 19036099 2022982 In particular , *induced* an early , significant inhibition of [SPHK1] activity , impaired cell cycle progression and triggered apoptosis in K562 cells . Negative_regulation SPHK1 SKIV2L 20948165 2347959 To determine if endogenously generated sphingosine-1-phosphate (S1P) is involved in the development of allergic bronchial asthma , the effects of systemic treatments with , a specific *inhibitor* of [sphingosine kinase] , on antigen induced bronchial smooth muscle ( BSM ) hyperresponsiveness and airway inflammation were examined in mice . Negative_regulation SPHK1 SPHK1 17686057 1781498 IL-6 stimulation or retroviral mediated overexpression of in MM cells *resulted* in increased intracellular [SPHK] activity and upregulation of myeloid cell leukaemia-1 (Mcl-1) , leading to increased cell proliferation and survival . Negative_regulation SPHK1 SPHK1 18362204 1938126 Another inhibitor , D , L-threo-dihydrosphingosine , also induced apoptosis and produced dramatic *increases* in [SphK1] expression . Negative_regulation SPHK1 SPHK2 18362204 1938127 Another inhibitor , D , L-threo-dihydrosphingosine , also induced apoptosis and produced dramatic *increases* in [SphK1] expression . Negative_regulation SPHK1 TNF 15710602 1395745 *induces* the loss of [sphingosine kinase-1] by a cathepsin B-dependent mechanism . Negative_regulation SPHK1 TNF 21148274 2402004 stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF-alpha to activate nuclear factor kappaB and *reduced* [sphingosine kinase-1] activity . Negative_regulation SPHK1 TTC37 19036099 2022983 In particular , *induced* an early , significant inhibition of [SPHK1] activity , impaired cell cycle progression and triggered apoptosis in K562 cells . Negative_regulation SPHK1 WDR61 19036099 2022984 In particular , *induced* an early , significant inhibition of [SPHK1] activity , impaired cell cycle progression and triggered apoptosis in K562 cells . Negative_regulation SPHK2 MAP2K6 15242760 1270695 This effect was inhibited by mitogen activated protein ERK kinase ( ) and [sphingosine kinase (SK)] *inhibitors* , indicating that prosaposin prevents cell apoptosis by activation of extracellular signal regulated kinases ( ERKs ) and sphingosine kinase . Negative_regulation SPHK2 SPHK1 17686057 1781500 IL-6 stimulation or retroviral mediated overexpression of in MM cells *resulted* in increased intracellular [SPHK] activity and upregulation of myeloid cell leukaemia-1 (Mcl-1) , leading to increased cell proliferation and survival . Negative_regulation SPINK1 MUC16 3117086 79214 The levels of tumour associated trypsin *inhibitor* ( [TATI] ) , and CEA were measured in ovarian cyst fluids from 21 patients . Negative_regulation SPP1 ANGPT1 12811821 1102907 Expression of alpha-smooth muscle ( SM ) actin , apparent in the contractile phenotype , was decreased by FN. Expressions of matrix Gla and [osteopontin] , apparent in the synthetic phenotype , were increased by FN . Ang II measured by radioimmunoassay ( RIA ) was significantly increased in human VSMC by FN. Expression of mRNAs for Ang II-generating proteases cathepsin D , cathepsin G , ACE , and chymase was increased by FN. Expressions of cathepsin D and cathepsin G proteins were also *increased* by FN. activity , which was inhibited by an aspartyl protease inhibitor pepstatin A , was readily detected in the conditioned medium from human VSMC . Negative_regulation SPP1 EPHB2 16440309 1554566 The flow-induction of COL1 was blocked by an inhibitor ( PD98059 ) and *reduced* by a JNK inhibitor ( SP600125 ) , whereas that of [OPN] was abolished by PD98059 . Negative_regulation SPP1 IL1B 16211580 1507918 Stimulation with *resulted* in the secretion of soluble [osteopontin] protein . Negative_regulation SPP1 IL1B 19136283 2079116 However , only TNFalpha inhibited osteonectin and [osteopontin] mRNA expression and only *reduced* cell proliferation . Negative_regulation SPP1 SPHK1 10626811 576266 In addition , in MCF-7 cells , overexpression of , the enzyme that produces SPP , inhibited chemotactic motility compared with vector transfected cells and markedly *increased* cellular [SPP] levels in the absence of detectable secretion . Negative_regulation SPP1 TNF 19136283 2079115 However , only *inhibited* osteonectin and [osteopontin] mRNA expression and only IL-1beta reduced cell proliferation . Negative_regulation SPP2 SPHK1 10626811 576268 In addition , in MCF-7 cells , overexpression of , the enzyme that produces SPP , inhibited chemotactic motility compared with vector transfected cells and markedly *increased* cellular [SPP] levels in the absence of detectable secretion . Negative_regulation SPRED2 EPHB2 18799725 1986900 AKT and activation and *inhibition* of [Spred2] were detected in HSCs from aged FoxO3a-deficient mice . Negative_regulation SPRR1B FOSL1 11313996 806226 Overexpression of in malignant cells significantly *enhanced* [SPRR1B] promoter activity . Negative_regulation SPRR3 IL13 15731505 1396367 Transgenic overexpression of in the lungs *resulted* in a marked increase of [SPRR2] expression , and allergen induced SPRR2 expression was significantly decreased in IL-13-deficient mice . Negative_regulation SPRR3 MAPK9 18234997 1864336 Inhibiting production by siRNA in osmotically stressed PCHCE cells *prevented* the stimulation of [SPRR] and membrane associated TG1 production and TG activity , and improved cell viability , whereas inhibition of JNK1 prevented early apoptosis . Negative_regulation SPRY1 TNF 23074166 2740416 Blocking ameliorated the inflammatory environment and significantly enhanced bone formation with increased miR-21 expression and *suppressed* [Spry1] expression in ovariectomized ( OVX ) mice . Negative_regulation SPRY2 TNF 18713620 1961535 Here , we demonstrated that the intracellular protein level of [Spry2] was significantly *down-regulated* by in both murine Swiss 3T3 fibroblasts and MLE15 lung epithelial cells . Negative_regulation SPRY2 TNF 18713620 1961536 Although TNF-alpha activates multiple signaling cascades , only the inhibitor of p38 MAPK pathway blocked *induced* [Spry2] down-regulation . Negative_regulation SPRY2 TNF 18713620 1961537 Importantly , rescue of the *induced* down-regulation of [Spry2] by gene overexpression led to reverse of the apoptotic effect of TNF-alpha in Swiss 3T3 cells . Negative_regulation SRC ANGPT1 18194650 1857016 *inhibits* the activation of [Src] by VEGF , the most upstream component of the pathway linking VEGF receptors to VE-cadherin internalization . Negative_regulation SRC EPHB2 22766276 2645071 However , U0126 , an inhibitor of , *had* no significant effect on the CsA induced activation of FAK and [Src] . Negative_regulation SRC EPHB2 24440771 2912776 Although the levels of phosphorylated Src were up-regulated simultaneously with ERK reactivation , neither suppression using U0126 nor an ERK-specific siRNA *induced* [Src] phosphorylation . Negative_regulation SRC ID1 18381431 1892883 PP2 , AZD0530 , and dominant negative Src abrogated promoter activity , which was *induced* by constitutively active [Src] . Negative_regulation SRC IL1B 16338964 1503956 In agreement with the pharmacologic inhibition studies , siRNA directed against c-Src specifically limited [c-Src] protein expression and *inhibited* mediated induction of NF-kappaB DNA binding activity , whereas control siRNA had no effect . Negative_regulation SRC ITGB2 21658109 2451123 Pretreatment of neutrophils with a monoclonal antibody to CD18 , ß chain of lymphocyte function associated molecule 1 ( ) , or an [Src] family tyrosine kinase *inhibitor* before incubation with the highly leukotoxic strain inhibited the release of resistin . Negative_regulation SRC JAG1 11427524 843309 We also report that the sJ1 mediated induction of [Src] activity and related phenotypes , including chord formation , may *result* from the inhibition of endogenous Notch signaling since it was not possible to detect an sJ1 dependent induction of CSL dependent transcription in these cells . Negative_regulation SRC NEDD9 24058594 2846564 Overexpression of *led* to tyrosine phosphorylation of FAK and [SRC] oncoproteins , and increased cell migration and invasion . Negative_regulation SREBF1 CLU 23515283 2772225 In reporter assays , *inhibited* [SREBP-1c] promoter activity . Negative_regulation SREBF1 CLU 23515283 2772226 Reporter and gel shift assays showed that *inhibits* [SREBP-1c] expression via the repression of LXR and specificity protein 1 activity . Negative_regulation SREBF1 FAS 11160371 781719 Moreover , overexpression of [ADD-1/SREBP-1] by adenoviral gene transfer *induces* in chicken adipocytes , where lipogenesis is normally low . Negative_regulation SREBF1 FOXO1 18202130 1895366 In addition , *suppressed* RXRalpha/LXRalpha mediated [SREBP1c] promoter activity in vitro . Negative_regulation SREBF1 FOXO1 20868688 2331936 *represses* LXRa mediated transcriptional activity of [SREBP-1c] promoter in HepG2 cells . Negative_regulation SREBF1 FOXO1 20868688 2331938 *mediated* suppression of [SREBP-1c] promoter activity could be partially alleviated by insulin . Negative_regulation SREBF1 FOXO1 22511764 2607881 Similarly , in primary hepatocytes , *suppressed* [SREBP1-c] expression and inhibited basal and insulin induced SREBP-1c promoter activity . Negative_regulation SREBF1 FOXO1 22511764 2607882 [SREBP-1c] gene expression is induced by the liver X receptor ( LXR ) , but did not *block* the activation of SREBP-1c by the LXR agonist TO9 . Negative_regulation SREBF1 FOXO1 22511764 2607884 *inhibited* [SREBP-1c] by reducing the transactivational capacity of both Sp1 and SREBP-1c . Negative_regulation SREBF1 FOXO1 22511764 2607886 We conclude that *inhibits* [SREBP-1c] transcription via combined actions on multiple transcription factors and that this effect is exerted at least in part through reduced transcriptional activity of Sp1 and SREBP-1c and disrupted assembly of the transcriptional initiation complex on the SREBP-1c promoter . Negative_regulation SREBF1 TNF 20404035 2246077 also induced Cd36 and peroxisome proliferators activated receptor ( Ppar)gamma expression , as well as microsomal triglyceride transfer protein ( Mtp ) protein and mRNA , but *suppressed* the sterol regulatory element binding protein ( [Srebp)1c] protein and mRNA level . Negative_regulation SREBF2 EPHB2 18403372 1914152 An cascade inhibitor , U0126 , inversely *augmented* SUMO modification of [SREBP-2] . Negative_regulation SRF IL1B 16477012 1554862 *inhibited* the polymerized collagen induced [serum response factor] DNA binding activity in the nucleus , and this effect was mediated by the PDGFR-beta/IL-1R1 association and phosphatidylinositol 3-kinase/Akt/p70S6K pathway . Negative_regulation SRGN BID 16519038 1496258 BIAsp 30 can *reduce* [PPG] levels to a greater extent than other common treatment regimens , including basal insulin OD . Negative_regulation SRP14 SMN2 23221635 2731371 Our data show that reduced levels of the protein *lead* to defect in [SRP] steady-state level and describe the SMN complex as the first identified cellular factor required for SRP biogenesis . Negative_regulation SRP19 SMN2 23221635 2731378 Our data show that reduced levels of the protein *lead* to defect in [SRP] steady-state level and describe the SMN complex as the first identified cellular factor required for SRP biogenesis . Negative_regulation SRP54 SMN2 23221635 2731385 Our data show that reduced levels of the protein *lead* to defect in [SRP] steady-state level and describe the SMN complex as the first identified cellular factor required for SRP biogenesis . Negative_regulation SRP68 SMN2 23221635 2731392 Our data show that reduced levels of the protein *lead* to defect in [SRP] steady-state level and describe the SMN complex as the first identified cellular factor required for SRP biogenesis . Negative_regulation SRP72 SMN2 23221635 2731399 Our data show that reduced levels of the protein *lead* to defect in [SRP] steady-state level and describe the SMN complex as the first identified cellular factor required for SRP biogenesis . Negative_regulation SRP9 SMN2 23221635 2731406 Our data show that reduced levels of the protein *lead* to defect in [SRP] steady-state level and describe the SMN complex as the first identified cellular factor required for SRP biogenesis . Negative_regulation SSB TNF 8134404 251723 One day after treatment with 125 micrograms TCDD/kg , *resulted* in 70 , 27 , 33 and 21 % decreases in [DNA-SSB] , mitochondrial and microsomal lipid peroxidation and PLC activation , respectively , relative to TCDD treated mice . Negative_regulation SST TNF 15680393 1370367 ( 1 ng/ml ) *reduced* [SST] , SSTR-1 , SSTR-2 , and SSTR-5 by 93 , 51 , 85 , and 99 % , respectively , compared to controls ( P < 0.001 , t test ) . Negative_regulation SSTR2 TNF 15680393 1370368 ( 1 ng/ml ) *reduced* SST , SSTR-1 , [SSTR-2] , and SSTR-5 by 93 , 51 , 85 , and 99 % , respectively , compared to controls ( P < 0.001 , t test ) . Negative_regulation SSTR5 TNF 15680393 1370369 ( 1 ng/ml ) *reduced* SST , SSTR-1 , SSTR-2 , and [SSTR-5] by 93 , 51 , 85 , and 99 % , respectively , compared to controls ( P < 0.001 , t test ) . Negative_regulation ST13 TNF 2663142 114512 [P48] activity is not *blocked* by either and anti-TNF-beta and on Western blot analysis is antigenically distinct from TNF-alpha and TNF-beta . Negative_regulation ST8SIA1 GNE 16847058 1606777 Overexpression of recombinant in human embryonic kidney ( HEK AD293 ) cells *led* to an increase in mRNA levels for ST3Gal5 ( GM3 synthase ) and [ST8Sia1] ( GD3 synthase ) as well as the biosynthetic products of these sialyltransferases , the GM3 and GD3 gangliosides . Negative_regulation STAR EPHB2 16166197 1525414 Interestingly , inhibition of activity *enhanced* IGF-I mediated [StAR] protein expression , but phosphorylation of StAR was undetectable , an observation in contrast to that seen with N , O'-dibutyrl-cAMP signaling . Negative_regulation STAR EPHB2 16901926 1601343 Inhibition of activity *enhanced* TGFalpha mediated [StAR] protein expression ( but not its phosphorylation ) and decreased progesterone synthesis , events correlated with the expression of dosage-sensitive sex reversal , adrenal hypoplasia congenita , critical region on the X chromosome , gene 1 ( DAX-1 ) and scavenger receptor class B type 1 ( SR-B1 ) . Negative_regulation STAR KLF9 18056793 1861292 Transient transfection of KLF4 , , and KLF13 *suppressed* LDLR/luc , [StAR/luc] , and CYP11A/luc by 80-90 % ( P < 0.001 ) . Negative_regulation STAR TNF 12054739 951470 *reduced* considerably intracellular levels of [StAR] protein , a key regulating factor in steroidogenesis . Negative_regulation STAR TNF 9916010 587447 significantly *inhibited* hCG/PRL induced [StAR] and LHR mRNA expression at 1 and 3 h post-TNFalpha . Negative_regulation STAT1 CTGF 17116388 1700605 Inhibitory effects of interferon-gamma on activation of rat pancreatic stellate cells are mediated by [STAT1] and *involve* down-regulation of expression . Negative_regulation STAT1 EPHB2 18378670 1912979 Moreover , silencing betaTRCP expression or pharmacological inhibition of activity *stabilized* [STAT1] expression . Negative_regulation STAT1 EPHB2 23274199 2763905 Western blot analysis revealed that the tocilizumab enhanced the interferon induced phosphorylation of [STAT1] and *inhibited* SOCS3 expression and the phosphorylation of both STAT3 and . Negative_regulation STAT1 FHL1 15963787 1423177 Overexpression of *leads* to impaired [STAT1] and STAT4 activity due to reduced STAT protein levels , while SLIM-deficiency results in increased STAT expression and thus enhanced IFNgamma production by Th1 cells . Negative_regulation STAT1 IL1B 11034404 740731 Furthermore , *attenuated* IFN-alphabeta induced [STAT1] binding and tyrosine phosphorylation without affecting the level of STAT1 protein . Negative_regulation STAT1 IL1B 11104703 756486 Furthermore , selectively *down-regulated* the IL-6 induced tyrosine phosphorylation of [STAT1] without affecting the level of STAT1 or tyrosine phosphorylation of STAT3 . Negative_regulation STAT1 IL1B 15749911 1379792 We also show that induces phosphorylation and nuclear translocation of IRF3 and *delayed* phosphorylation of [STAT1] . Negative_regulation STAT1 MAP2K6 10514514 651894 Overexpression of wild-type p38 mitogen activated protein kinase and its upstream activator 6 ( MKK6 ) *resulted* in an enhanced [STAT1] tyrosine phosphorylation upon osmotic shock . Negative_regulation STAT1 MAP2K6 10924861 718425 Genistein , a tyrosine kinase inhibitor , H7 , a serine/threonine kinase inhibitor , and PD 98059 , a inhibitor , *prevented* the UVA induced enhancement of [STAT1] binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Negative_regulation STAT1 MAP2K6 16686690 1560213 Most significantly , direct inhibition of was *sufficient* to trigger JAK dependent [STAT1] expression , suggesting that cross-talk between MEK/ERK and JAK/STAT pathways plays a key role in regulating neuronal survival . Negative_regulation STAT1 TNF 19782030 2141211 LXR ligands inhibit neither STAT1 phosphorylation nor [STAT1] translocation to the nucleus but , rather , *inhibit* STAT1 binding to promoters and the expression of IRF1 , , and IL-6 , downstream effectors of STAT1 action . Negative_regulation STAT1 TNF 8631837 361299 Only [STAT 1] is *down-regulated* by in fully differentiated cells . Negative_regulation STAT3 CCND1 11279133 811823 *represses* [STAT3] activation through a Cdk4 independent mechanism . Negative_regulation STAT3 CCND1 11279133 811824 In this study , we show that *inhibits* [STAT3] activation . Negative_regulation STAT3 CCND1 16954476 1611041 In HBL100 and T47D parental and cyclin D1-overexpressing cells , cyclin D1 overexpression was also inversely associated with STAT3 expression , and directly *reduced* the expression of [STAT3] . Negative_regulation STAT3 CCND1 18245487 1865120 We show that *repression* of [STAT3] by inhibits cell growth on Matrigel and in tumors in vivo ; Negative_regulation STAT3 CCND1 22174819 2518340 Mechanistic characterization revealed that NSC-743380 suppressed the phosphorylation of C-terminal domain of RNA polymerase II , induced JNK activation , *inhibited* [JAK2/STAT3] phosphorylation and suppressed expression in sensitive human cancer cells . Negative_regulation STAT3 CCND1 23726368 2865710 *Repression* of [STAT3] activity by might also play a previously unrecognized role in providing a germline-selective advantage to spermatogonia for the recurrent mutations in the receptor tyrosine kinases that cause Apert syndrome and MEN2B . Negative_regulation STAT3 DAPK1 23438478 2749032 *attenuated* [STAT3] activity directly by physical interaction shown in three-dimensional structural modeling . Negative_regulation STAT3 EPHB2 11780390 891068 *inhibited* [STAT3] activation by IL-6 . Negative_regulation STAT3 EPHB2 15805288 1390979 The biological significance of *mediated* inhibition of [STAT3] ( ( Tyr705 ) ) phosphorylation was further assessed by treating the cells with an inhibitor ( PD98059 ) of mitogen activated protein kinase kinase ( MEK ) or by transfecting the cells with a vector that expresses constitutively active MEK-1 . Negative_regulation STAT3 EPHB2 15805288 1390980 Expression of constitutively active MEK-1 caused an increase of activity and *inhibited* [STAT3] ( ( Tyr705 ) ) phosphorylation . Negative_regulation STAT3 EPHB2 22648519 2686840 Further analysis demonstrated that ISL not only downregulated IL-6 expression but also significantly decreased levels of phosphorylated ERK and [STAT3] and could *inhibit* phosphorylation levels of and STAT3 induced by recombinant human IL-6 , which are critical signaling proteins in IL-6 signaling regulation networks . Negative_regulation STAT3 EPHB2 23114032 2717430 Notably , genetic ( MEK1 silencing ) or chemical ( U0126 ) inhibition of signaling *restored* constitutive [STAT3] phosphorylation and inhibited the differentiation of SHED into endothelial cells . Negative_regulation STAT3 MAP2K6 11591128 869419 To assess the relative importance of these pathways in promoting the survival of cytokine dependent neurons , we conditionally inactivated [STAT3] in mice and *inhibited* , PI3K , and Akt in cultured neurons using pharmacological reagents and by expressing specific inhibitory proteins . Negative_regulation STAT3 MAP2K6 20379953 2319793 Inhibition of significantly *blocked* the effects of kansuinine A and B on IL-6 induced [Stat3] activation and tyrosine phosphorylation . Negative_regulation STAT3 MAP2K6 25065853 2953695 Specifically , inhibition *led* to autocrine activation of [Stat3] via the FGF receptor and JAK kinases , and pharmacological inhibition of MEK together with JAK and FGFR enhanced tumor regression . Negative_regulation STAT3 MUC16 24812549 2939848 The loss of *activated* [Stat3] signal , affected JunB signal , and upregulated the expression of IL-6 in the conjunctiva . Negative_regulation STAT3 TNF 10606755 575159 LPS and induce SOCS3 mRNA and *inhibit* IL-6 induced activation of [STAT3] in macrophages . Negative_regulation STAT3 TNF 12817006 1103553 Recently , it has been demonstrated that and LPS induce the expression of suppressor of cytokine signaling 3 ( SOCS3 ) and *inhibit* IL-6 induced [STAT3] activation in macrophages . Negative_regulation STAT3 TNF 15749890 1379740 In vitro , IL-27 induced [STAT3] phosphorylation and *inhibited* and IL-12 production in activated peritoneal macrophages , indicating a novel feedback mechanism by which IL-27 can modulate excessive inflammation . Negative_regulation STAT4 CISH 15778369 1384894 Importantly , the expression of , a potent *inhibitor* of IL-12 induced [Stat4] activation , was decreased in Stat5a ( -/- ) CD4 ( + ) T cells . Negative_regulation STAT4 EZH2 24760151 2936865 inhibition *resulted* in significant decrease in the expression of Tbx21 and [Stat4] , which encode transcription factors T-bet and STAT4 , respectively . Negative_regulation STAT4 FHL1 15963787 1423178 Overexpression of *leads* to impaired STAT1 and [STAT4] activity due to reduced STAT protein levels , while SLIM-deficiency results in increased STAT expression and thus enhanced IFNgamma production by Th1 cells . Negative_regulation STAT4 GATA3 15251440 1271477 Among several transcription factors putatively interacting with this region , [Stat4] , which enhanced IFN-gamma promoter activity , was *down-regulated* by at gene transcription level . Negative_regulation STAT4 HNRNPF 10861035 705111 Receptor engagement of as well as Con A blasts by IL-12 *resulted* in activation of Janus kinase 2 and Tyk2 kinases and Stat3 and [Stat4] transcription factors and the association of these proteins to IL-12Rbeta1 . Negative_regulation STAT4 HNRNPF 16849477 1588458 Indeed , in the present study we found that bone marrow derived transduced with SOCS-3 significantly *inhibited* IL-12 induced activation of [Stat4] and IL-23 induced activation of Stat3 . Negative_regulation STAT4 HNRNPH1 10861035 705112 Receptor engagement of as well as Con A blasts by IL-12 *resulted* in activation of Janus kinase 2 and Tyk2 kinases and Stat3 and [Stat4] transcription factors and the association of these proteins to IL-12Rbeta1 . Negative_regulation STAT4 HNRNPH1 16849477 1588459 Indeed , in the present study we found that bone marrow derived transduced with SOCS-3 significantly *inhibited* IL-12 induced activation of [Stat4] and IL-23 induced activation of Stat3 . Negative_regulation STAT4 IL12A 10566142 567449 signaling *results* in [STAT4] activation and interferon (IFN)-gamma production . Negative_regulation STAT4 IL12A 12637316 1099193 In exploring possible molecular mechanisms to account for the synergistic effects of IL-4 on murine NK cells , we found that IL-2 plus IL-4 stimulation resulted in a modest increase in tyrosine phosphorylation of Stat5 , while plus IL-4 treatment *resulted* in a more substantial increase in tyrosine phosphorylated [Stat4] . Negative_regulation STAT4 IL12A 15005728 1217490 In atopic patients with the C-to-U conversion , PBMCs faintly showed the tyrosine phosphorylation of [Stat4] , and the IgE production by PBMCs was not *suppressed* by whereas it was suppressed by IFN-gamma . Negative_regulation STAT4 IL12A 21813204 2495444 Exposure of splenocytes to AEBSF for 3h noticeably *inhibited* the induction of IFN? , IL-12 , and IL-12 induced [STAT4ß] , mRNA expression of T-bet and . Negative_regulation STAT4 IL12B 10566142 567450 signaling *results* in [STAT4] activation and interferon (IFN)-gamma production . Negative_regulation STAT4 IL12B 12637316 1099194 In exploring possible molecular mechanisms to account for the synergistic effects of IL-4 on murine NK cells , we found that IL-2 plus IL-4 stimulation resulted in a modest increase in tyrosine phosphorylation of Stat5 , while plus IL-4 treatment *resulted* in a more substantial increase in tyrosine phosphorylated [Stat4] . Negative_regulation STAT4 IL12B 15005728 1217491 In atopic patients with the C-to-U conversion , PBMCs faintly showed the tyrosine phosphorylation of [Stat4] , and the IgE production by PBMCs was not *suppressed* by whereas it was suppressed by IFN-gamma . Negative_regulation STAT4 IL12B 21813204 2495445 Exposure of splenocytes to AEBSF for 3h noticeably *inhibited* the induction of IFN? , IL-12 , and IL-12 induced [STAT4ß] , mRNA expression of T-bet and . Negative_regulation STAT4 IL4 11207258 786863 The production of IFN-gamma by IL-12/IL-18 activated macrophages requires [STAT4] signaling and is *inhibited* by . Negative_regulation STAT4 MAPK1 10820390 694510 The object of the present study was to explore the *role* of mitogen activated protein kinases (MAPK) Erk1 and and phosphatidylinositol 3-kinase (PI3K) in [STAT4] regulation . Negative_regulation STAT4 MAPK3 10820390 694511 The object of the present study was to explore the *role* of mitogen activated protein kinases (MAPK) and Erk2 and phosphatidylinositol 3-kinase (PI3K) in [STAT4] regulation . Negative_regulation STAT4 PI3 10820390 694512 The object of the present study was to explore the *role* of mitogen activated protein kinases (MAPK) Erk1 and Erk2 and in [STAT4] regulation . Negative_regulation STAT4 PNRC1 12594853 1061121 In contrast , A1 but not *inhibited* [STAT4/STAT3] phosphorylation and IFN-gamma production . Negative_regulation STAT4 PTBP1 10861035 705113 Receptor engagement of as well as Con A blasts by IL-12 *resulted* in activation of Janus kinase 2 and Tyk2 kinases and Stat3 and [Stat4] transcription factors and the association of these proteins to IL-12Rbeta1 . Negative_regulation STAT4 PTBP1 16849477 1588460 Indeed , in the present study we found that bone marrow derived transduced with SOCS-3 significantly *inhibited* IL-12 induced activation of [Stat4] and IL-23 induced activation of Stat3 . Negative_regulation STAT4 PTBP2 10861035 705110 Receptor engagement of as well as Con A blasts by IL-12 *resulted* in activation of Janus kinase 2 and Tyk2 kinases and Stat3 and [Stat4] transcription factors and the association of these proteins to IL-12Rbeta1 . Negative_regulation STAT4 PTBP2 16849477 1588457 Indeed , in the present study we found that bone marrow derived transduced with SOCS-3 significantly *inhibited* IL-12 induced activation of [Stat4] and IL-23 induced activation of Stat3 . Negative_regulation STAT4 SLC25A3 17306571 1699134 In CD4 ( + ) T cells , deficiency *leads* to increased and prolonged activation of [STAT4] and STAT6 , and consequently enhanced T helper 1 (Th1) and Th2 cell differentiation . Negative_regulation STAT4 SOCS3 14559241 1153808 *inhibits* IL-12 induced [STAT4] activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit . Negative_regulation STAT4 STAT1 14688355 1190724 In addition , recent studies have suggested that the ability of to *inhibit* the activation of [STAT4] prevents the development of Th1 responses . Negative_regulation STAT4 STAT1 17015705 1629845 Furthermore , loss of *increases* IFN-alpha induced [STAT4] phosphorylation , but does not generate levels of STAT4 activation or IFN-gamma production achieved by IL-12 or convert transient STAT4 activation into a sustained response . Negative_regulation STAT4 STAT6 15459017 1359197 The absence of [Stat4] expression in cultured mast cells was *due* to the presence of . Negative_regulation STAT4 TGFB1 10072548 594524 Furthermore , gel shift analysis showed that did not *prevent* activated [STAT4] and STAT5A from binding to DNA . Negative_regulation STAT5A EPHB2 23560534 2782965 Western blot confirmed that ruxolitinib blocked , and consequently STAT5 activation , sorafenib *inhibited* ERK , P38 and [STAT5] , dasatinib blocked SRC and STAT5 , and KNK437 decreased the stability of the JAK2 protein , reducing its expression . Negative_regulation STAT5A TNF 12519742 1063826 We have reported that suppresses hepatic GH receptor (GHR) gene expression , whereas the cytokine-inducible SH2 containing protein 1 ( Cis ) /suppressors of cytokine signaling (Socs) genes are upregulated by TNF-alpha and IL-6 and *inhibit* GH activation of [STAT5] . Negative_regulation STAT5A TNF 15887111 1407048 down-regulated GHR abundance and *prevented* GH-induced tyrosine phosphorylation of [STAT5] in rat hepatocytes in culture . Negative_regulation STAT5A TNF 16574984 1568536 *attenuated* [JAK2/STAT5] and ERK1/2 phosphorylation and IGF-I and Spi 2.1 mRNA expression following GH stimulation . Negative_regulation STAT5A TNF 9862421 555906 *inhibits* insulin induced [STAT5] activation in differentiated mouse muscle cells pmi28 . Negative_regulation STAT5B MAP2K6 10350046 616997 However , inhibition of *had* no effect on the phosphorylation level of [Stat5b] or on the nuclear translocation of Stat5b . Negative_regulation STAT6 CAPN8 18945965 2028734 Our data suggest that , an oxidative stress induced cysteine protease , is *involved* in the PRELI induced down-regulation of [STAT6] . Negative_regulation STAT6 TNF 10202031 605919 also *blocked* IL-4 induced tyrosine phosphorylation of IRS-2 , but not of [STAT6] . Negative_regulation STEAP4 TNF 18430367 1900137 Finally , we confirmed that cultured human omental adipose tissue undergoes *mediated* regulation of the [STEAP4] expression . Negative_regulation STIM1 FAS 20643097 2304790 Here we show that activation of receptor in T-cells *results* in caspase dependent decrease of cellular [STIM1] and Orai1 protein content . Negative_regulation STK39 ABL1 10637231 660258 Surprisingly , elevated levels of c-Jun activated nuclear , *resulting* in activation of the JNK [serine/threonine kinase] . Negative_regulation STK39 BCR 8955135 401258 By contrast , tyrosine phosphorylation of by FES *suppressed* BCR [serine/threonine kinase] activity toward the 14-3-3 protein and BCR substrate , BAP-1 . Negative_regulation STK39 CD79A 8955135 401259 By contrast , tyrosine phosphorylation of by FES *suppressed* BCR [serine/threonine kinase] activity toward the 14-3-3 protein and BCR substrate , BAP-1 . Negative_regulation STK39 CD79B 8955135 401260 By contrast , tyrosine phosphorylation of by FES *suppressed* BCR [serine/threonine kinase] activity toward the 14-3-3 protein and BCR substrate , BAP-1 . Negative_regulation STK39 CDC7 24900258 2523210 A ligand based 3D pharmacophore model for [serine/threonine kinase] *inhibition* was created and successfully applied in the discovery of novel 2- ( heteroaryl ) -6,7-dihydrothieno [ 3,2-c ] pyridin-4 ( 5H ) -ones . Negative_regulation STK39 CSK 10951585 723809 Such co-expression is consistent with a *role* for Hydra in regulation of [STK] activity . Negative_regulation STK39 CSK 10951585 723854 Phosphotyrosine immunoblot analysis confirmed that expression of *resulted* in suppression of [STK] kinase activity . Negative_regulation STK39 ERBB2 14633703 1170811 AKT , a [serine/threonine kinase] that promotes cell survival , can be *activated* by overexpression of the receptor tyrosine kinase . Negative_regulation STK39 IL2 1639773 194664 Stimulation of the receptor *results* in phosphorylation and activation of cytosolic Raf-1 [serine/threonine kinase] . Negative_regulation STK39 MTOR 19483303 2085952 We investigated the effect of rapamycin , a specific *inhibitor* of the mammalian [serine/threonine kinase] , , on the expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS) stimulated RAW 264.7 cells . Negative_regulation STK39 PARP1 18239155 1884631 inhibition can also *activate* the prosurvival [serine/threonine kinase] , Akt . Negative_regulation STK39 PIK3CA 24348050 2880984 inhibition *induced* the most significant effects on global signaling pathways in patient derived cell cultures , especially on members of the mitogen activated protein-kinase family , P70S6 [serine-threonine kinase] , and cAMP response element binding protein expression and further prevented tumor cell proliferation . Negative_regulation STK39 PIK3R1 24348050 2880985 inhibition *induced* the most significant effects on global signaling pathways in patient derived cell cultures , especially on members of the mitogen activated protein-kinase family , P70S6 [serine-threonine kinase] , and cAMP response element binding protein expression and further prevented tumor cell proliferation . Negative_regulation STK39 STS 17170026 1717046 In this study , we used , a potent , cell-permeable , and broad-spectrum [serine/threonine kinase] *inhibitor* , and studied migration . Negative_regulation STK4 TNF 23085515 2713717 Furthermore , *prevented* the physical interaction between thioredoxin-1 and [MST1] and promoted the homodimerization and activation of MST1 . Negative_regulation STS MAOA 17883400 1830013 Increased levels of activity were *induced* by [STS] , accompanied by increased MAO-A protein and activation of the initiator of the intrinsic pathway , caspase 9 , and the executioner caspase 3 . Negative_regulation SULT2A1 TNF 15198932 1288893 Finally , we found that both and IL-1 *caused* a significant decrease in the mRNA level of [Sult2A1] in Hep3B human hepatoma cells , suggesting that the proinflammatory cytokines TNF and IL-1 mediate the inhibitory effect of LPS on Sult2A1 mRNA level . Negative_regulation SUSD2 CKAP4 25045846 2953412 The mRNA and protein levels of vimentin , twist , SUSD2 , and uPA were significantly decreased in p63-knockdown ESC cells , while overexpression of *induced* an increase in vimentin , [SUSD2] , and uPA . Negative_regulation SYK CAPN8 23684705 2811148 The inhibition of cellular stimulated the Syk mediated enhancement of NF-?B induced by TNF-a , enhanced tyrosine phosphorylation resulting from integrin crosslinking , and *increased* the localization of [Syk] to the plasma membrane . Negative_regulation SYMPK SCARA3 18806823 2021203 A mutant unable to bind to CPSF3 did not alter CPSF3 subcellular distribution , did not *inhibit* its [polyadenylation] activity and did not induce cell death . Negative_regulation SYNC DES 17629480 1822190 The data show that absence of alpha-dystrobrevin or *leads* to dynamic changes in [syncoilin] that may compensate for , or participate in , different muscle myopathies . Negative_regulation SYNC DTNA 17629480 1822191 The data show that absence of or desmin *leads* to dynamic changes in [syncoilin] that may compensate for , or participate in , different muscle myopathies . Negative_regulation SYNCRIP DAPK1 18995835 1990130 Inhibition of and ZIPK facilitates cell restoration to the basal state and *allows* renewed induction of [GAIT] target transcripts by repeated stimulation . Negative_regulation SYNM MBD2 6413080 30568 They include : ( i ) the presence of inhibitors of in extracts of low-activity strains , ( ii ) a sex bias in the Hikone-R strain in which the enzyme activity is confined to the females , ( iii ) the possibility that DMN treatment *induces* [DMN-demethylase] activity in the low-activity strains and ( iv ) the possibility that Hikone-R has a much more efficient DNA repair system than the other strains . Negative_regulation SYNM MBD2 6413080 30570 The results are discussed in terms of what is known about the *role* of in the metabolic activation of [DMN] in other systems . Negative_regulation SYNM PLEC 498363 10049 In vivo administration to rats of the mixed-function oxidase modifiers 3-methylcholanthrene ( MC ) , or beta-naphthoflavnoe ( beta-f ) *inhibits* the hepatic microsome catalyzed in vitro binding of [dimethylnitrosamine (DMN)] to DNA . Negative_regulation SYNM PLEC 498363 10050 In mice beta-NF enhances and *inhibits* [DMN-demethylase] I ; beta-NF has no effect on either the cytochrome P-450 level or on the LD50 , while PCN strongly increases the cytochrome P-450 level but without influencing the LD50 . Negative_regulation SYNPO TNF 23359116 2738822 Furthermore , conditioned media from mouse microvascular endothelial cells over expressing GFP-eNOS protected podocytes from *induced* loss of [synaptopodin] . Negative_regulation SYNPO TNF 23840712 2816262 In a podocyte cell line , RvD1 was shown to prevent rapid *induced* down-regulation of [synaptopodin] expression . Negative_regulation SYP MMP7 17115023 1677210 We found statistically significant correlations between metastatic tumor spread and overexpression of , MMP10/2 , tissue *inhibitor* of metalloproteinase 3 , vascular endothelial growth factor ( VEGF ) , P38 , stromal NF-kappaB , and [synaptophysin] . Negative_regulation SYT1 CCND1 20061362 2280830 In HT-29 cells , pterostilbene reduced the protein levels of beta-catenin , and c-MYC , altered the cellular localization of beta-catenin and *inhibited* the phosphorylation of [p65] . Negative_regulation SYT1 F2R 16467309 1548169 Activation of or PAR-2 promoted nuclear translocation and phosphorylation of p65-NF-kappaB , and thrombin induced but not PAR-2 induced [p65-NF-kappaB] phosphorylation was *reduced* by inhibition of MEK or p38MAPK . Negative_regulation SYT1 GPR132 17255525 1704080 Transfection of into G2A ( -/- ) ECs to restore normal expression levels *reduced* [p65] nuclear localization to 35 % . Negative_regulation SYT1 TNF 15857826 1418932 On the other hand , [NFkappaB-p65] transcriptional activity was substantially *reduced* by , which targeted a trans-activation domain at the very C terminus of the p65 molecule . Negative_regulation SYT1 TNF 18591781 1931386 Rg3 effectively reduced inflammatory cytokine expression in Abeta42 treated BV-2 , and *inhibited* the binding of NF-kappaB [p65] to its DNA consensus sequences , and significantly reduced the expression of in activated microglia . Negative_regulation SYT1 TNF 19326995 2052542 Furthermore , direct inhibition of also *increases* pulmonary expression of [p65] in virus infected BN , but not F344 , rats . Negative_regulation SYT1 TNF 23341882 2733872 PDTC significantly inhibited the expression of MMP9 and the phosphorylation of I?Ba , as well as the expression of phosphorylation [p65] protein in *response* to ( p < 0.05 ) . Negative_regulation SYT8 APP 19239106 2040493 The expression of and its truncated forms *caused* a decrease in the [synaptotagmin] content of antennal lobes and mushroom lobes of the D. melanogaster brain , as well as neurodegeneration that progressed with age . Negative_regulation SYT8 SV2A 20702688 2335536 Although they did not rescue normal neurotransmission , SV2A-W300A and did *restore* normal levels of [synaptotagmin] expression and internalization . Negative_regulation SYT8 SV2A 22220214 2519370 Overexpression of also *increased* synaptic levels of the calcium-sensor protein [synaptotagmin] , an SV2 binding protein whose stability and trafficking are regulated by SV2 . Negative_regulation TAB1 TNF 18316610 1880941 [TAB1] ( 411 ) expression also *inhibited* TGF-beta stimulated and cyclooxygenase-2 expression in 4T1 cells . Negative_regulation TAB2 FOXO1 20228261 2254422 IGF-1 prevents ANG II-induced skeletal muscle atrophy via Akt- and dependent *inhibition* of the [ubiquitin ligase] atrogin-1 expression . Negative_regulation TAB2 TLR7 24384074 2900104 *led* to a down-regulation of MARCH1 [ubiquitin ligase] which prevents the degradation of MHC-II and decreased IL-10 also contributed to an increase in MHC-II . Negative_regulation TAB2 TNF 19411063 2070933 Wu et al. , in this issue of Cancer Cell , show that dependent NFkappaB activation *induces* COP9 signalosome mediated inhibition of GSK3beta and the SCF(beta-TRCP) [ubiquitin ligase] , thus leading to stabilization of the transcription factor Snail and promoting cell migration and metastasis . Negative_regulation TAB3 TNF 14766965 1212038 Furthermore , the activation of NF-kappaB by [TAB3] was *blocked* by the NF-kappaB inhibitor , SN50 , and by expression of dominant negative forms of alpha associated factor 6 and transforming growth factor beta activated kinase . Negative_regulation TAC1 TNF 15665861 1365640 *reduces* [tachykinin] , PGE2 dependent , relaxation of the cultured mouse trachea by increasing the activity of COX-2 . Negative_regulation TAC3 TNF 15665861 1365641 *reduces* [tachykinin] , PGE2 dependent , relaxation of the cultured mouse trachea by increasing the activity of COX-2 . Negative_regulation TAC4 TNF 15665861 1365642 *reduces* [tachykinin] , PGE2 dependent , relaxation of the cultured mouse trachea by increasing the activity of COX-2 . Negative_regulation TAOK1 TNF 22025632 2508077 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation TAS1R3 IL1B 19505677 2098207 These results may suggest that trehalose *inhibits* LPS induced production of and TNF-alpha in mouse peritoneal macrophages by inhibiting degradation of IkappaB-alphavia the trehalose receptor [T1R3] . Negative_regulation TAS1R3 TNF 19505677 2098206 These results may suggest that trehalose *inhibits* LPS induced production of IL-1beta and in mouse peritoneal macrophages by inhibiting degradation of IkappaB-alphavia the trehalose receptor [T1R3] . Negative_regulation TAT CAPN8 22525374 2658644 Inhibition of the mPTP pore with [BH4-TAT] peptide , *inhibition* with PD150606 , or knockdown ( KD ) of Bnip3 failed to prevent nuclear translocation of these DNase although Bnip3 KD blocked mitochondrial fission . Negative_regulation TAT IFI27 19720293 2133718 Up-regulation of ( kip1 ) *resulted* in increased retention of [ ( 111 ) In ] -anti-p27 ( kip1 ) [-tat] in cells treated with trastuzumab . Negative_regulation TAT TNF 15349890 1292346 *suppressed* expression of mature liver-specific genes such as [tyrosine aminotransferase] and apolipoproteins . Negative_regulation TAT TNF 9758732 536306 Methylprednisolone treatment effectively inhibited the increases in and IL-6 and the decreases in AT-III and albumin , but did not *inhibit* the increases in PMN-elastase and [TAT] levels . Negative_regulation TAZ EPHB2 24125755 2889230 FGF2 induced TAZ expression was stimulated by ( extracellular signal regulated kinase ) activation and the inhibition of ERK *blocked* [TAZ] expression . Negative_regulation TBC1D4 TNF 19001549 2016188 The expression of DeltaIP-PTEN enhanced the phosphorylation of Akt1 at 120 min and that of Akt2 at 2 min. Interestingly , the expression of DeltaIP-SHIP2 , but not DeltaIP-PTEN , protected against the *inhibition* of insulin induced phosphorylation of Akt2 , GSK3 , and [AS160] , whereas both improved the TNF-alpha inhibition of insulin induced 2-deoxyglucose uptake . Negative_regulation TBCA RNASE1 16816186 1580984 Conversely , overexpression of a related , RNase G , in rne deleted bacteria *restores* [CFA] , as previously reported , without affecting FtsZ abundance . Negative_regulation TBCA RNASE7 16816186 1580992 Conversely , overexpression of a related , RNase G , in rne deleted bacteria *restores* [CFA] , as previously reported , without affecting FtsZ abundance . Negative_regulation TBCC TNF 15194531 1260082 In patients cytokines modulated normal and mutated clones differently : TGF-b reduced the number of PIG-A- and PIG-A+ colony-forming-cells (CFC) , whereas and IFN-gamma *reduced* PIG-A+ [CFC] only . Negative_regulation TBP MAP2K6 10878013 722437 The constitutive active -- > ERK pathway *inhibited* the phosphorylation of [TBP] , which is necessary for both interaction with RelA and binding to the TATA box . Negative_regulation TBP MAP2K6 11454854 850632 More importantly , expression of a constitutive active ( Glu ) *resulted* in the phosphorylation of a [His-TBP] fusion protein and increased direct interaction of TBP with c-Jun . Negative_regulation TBR1 NR2F1 16144621 1451536 By maintaining high ectopic expression of COUP-TFI in preplate cells , we show that *represses* the CR cell markers reelin and calretinin , and with lower efficiency the transcription factor [Tbr1] . Negative_regulation TCEA1 C1QTNF1 9002605 404749 The results of the present work support the possible *role* of in GA-induced corolla and stem [elongation] . Negative_regulation TCEA1 EPHB2 15067199 1231861 Taken together , the results demonstrate the functional *role* for and p23 in the neurite [elongation] activity of FK506 and reveal a novel signal transduction pathway involving p23 activation of ERK . Negative_regulation TCEA1 MAP2K6 15304225 1284532 Here , we tested this model , and we found that the capping function of HP1 is due to its direct binding to telomeric DNA , while the silencing of telomeric sequences and telomere [elongation] is *due* to its interaction with . Negative_regulation TCEA1 MAP2K6 16463277 1534575 A detailed study of growth cone behavior showed that the filopodial [elongation] *induced* by inhibiting PI-3K , Akt , ROCK , and was achieved by increasing two motility parameters : the rate with which filopodia extend ( extension rate ) and the time that filopodia spend elongating . Negative_regulation TCEA1 MAP2K6 20869211 2337198 Overexpression of the constitutive active form of *resulted* in significant [elongation] of dendrites in the melanoma cell line SK-mel-24 . Negative_regulation TCEA1 PLAU 8933768 398229 In the form deprived eyes , *inhibited* vitreous depth and axial length [elongation] , but PAI-1 had no effect . Negative_regulation TCEA1 RNASE1 11952127 930461 A tobacco S-like *inhibits* hyphal [elongation] of plant pathogens . Negative_regulation TCEA1 RNASE1 2425351 60429 subsequent [elongation] is *inhibited* by aphidicolin but not by . Negative_regulation TCEA1 RNASE7 11952127 930469 A tobacco S-like *inhibits* hyphal [elongation] of plant pathogens . Negative_regulation TCEA1 TMOD1 11054557 745724 By binding to the N-terminus of tropomyosin (TM) and actin , *blocks* the [elongation] and depolymerization of the actin filaments at the pointed end . Negative_regulation TCEA1 TMOD1 7798317 281061 In the absence of tropomyosin , acts as a `` leaky '' cap , partially *inhibiting* [elongation] and depolymerization at the pointed filament ends ( Kd for inhibition of elongation = 0.1-0.4 microM ) . Negative_regulation TCEA1 TNF 11826115 909369 These results suggest that glia derived , as part of an injury or inflammatory process , can *inhibit* neurite [elongation] and branching during development and regeneration . Negative_regulation TCEA1 TNF 9856801 555194 , however , strongly *inhibited* the [elongation] of the hair shaft in a dose dependent manner , accompanied by abnormal morphology and increased cell death in the bulb matrix cells . Negative_regulation TCEAL1 CCND1 12496058 1026249 It was also found that the expression of [P21] ( WAF1/CIP1 ) was significantly induced and the expression of and CDK4 was significantly *inhibited* in tea treated groups . Negative_regulation TCF12 ARSA 14566053 1158695 Thus , *inhibits* Beta-catenin mediated [TCF] activity by preventing the formation of the Beta-catenin/TCF-4 complex . Negative_regulation TCF12 CCND1 11788592 916921 *represses* the basic helix-loop-helix [transcription factor] , BETA2/NeuroD . Negative_regulation TCF12 EPHB2 16818788 1581361 Blocking the activation of *prevented* histone phosphorylation and [transcription factor] binding to the IL-10 promoter . Negative_regulation TCF12 FOXO1 22550000 2669243 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced dependent *inhibition* of [Wnt/TCF] activity . Negative_regulation TCF12 IFI27 17113786 1677028 Overexpression of the prosensory [transcription factor] , Math1 , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation TCF12 NGFR 8408202 233265 In this system neurons but not other cell types , repress the expression of Schwann cell while *inducing* the expression of the POU domain [transcription factor] , suppressed cAMP inducible POU , and myelin P0 . Negative_regulation TCF12 TNF 12893683 1135174 Electrophoretic mobility shift assay demonstrated that both GBE and probucol inhibited [transcription factor] nuclear factor-kappaB activation in TNF-alpha stimulated HAECs ( 55.2 % and 65.6 % inhibitions , respectively ) but only GBE could *inhibit* the stimulated activator protein 1 activation ( 45.1 % inhibition , P < 0.05 ) . Negative_regulation TCF15 ARSA 14566053 1158696 Thus , *inhibits* Beta-catenin mediated [TCF] activity by preventing the formation of the Beta-catenin/TCF-4 complex . Negative_regulation TCF15 CCND1 11788592 916922 *represses* the basic helix-loop-helix [transcription factor] , BETA2/NeuroD . Negative_regulation TCF15 EPHB2 16818788 1581362 Blocking the activation of *prevented* histone phosphorylation and [transcription factor] binding to the IL-10 promoter . Negative_regulation TCF15 FOXO1 22550000 2669247 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced dependent *inhibition* of [Wnt/TCF] activity . Negative_regulation TCF15 IFI27 17113786 1677033 Overexpression of the prosensory [transcription factor] , Math1 , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation TCF15 NGFR 8408202 233267 In this system neurons but not other cell types , repress the expression of Schwann cell while *inducing* the expression of the POU domain [transcription factor] , suppressed cAMP inducible POU , and myelin P0 . Negative_regulation TCF15 TNF 12893683 1135176 Electrophoretic mobility shift assay demonstrated that both GBE and probucol inhibited [transcription factor] nuclear factor-kappaB activation in TNF-alpha stimulated HAECs ( 55.2 % and 65.6 % inhibitions , respectively ) but only GBE could *inhibit* the stimulated activator protein 1 activation ( 45.1 % inhibition , P < 0.05 ) . Negative_regulation TCF19 ARSA 14566053 1158697 Thus , *inhibits* Beta-catenin mediated [TCF] activity by preventing the formation of the Beta-catenin/TCF-4 complex . Negative_regulation TCF19 CCND1 11788592 916923 *represses* the basic helix-loop-helix [transcription factor] , BETA2/NeuroD . Negative_regulation TCF19 EPHB2 16818788 1581363 Blocking the activation of *prevented* histone phosphorylation and [transcription factor] binding to the IL-10 promoter . Negative_regulation TCF19 FOXO1 22550000 2669251 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced dependent *inhibition* of [Wnt/TCF] activity . Negative_regulation TCF19 IFI27 17113786 1677038 Overexpression of the prosensory [transcription factor] , Math1 , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation TCF19 NGFR 8408202 233269 In this system neurons but not other cell types , repress the expression of Schwann cell while *inducing* the expression of the POU domain [transcription factor] , suppressed cAMP inducible POU , and myelin P0 . Negative_regulation TCF19 TNF 12893683 1135178 Electrophoretic mobility shift assay demonstrated that both GBE and probucol inhibited [transcription factor] nuclear factor-kappaB activation in TNF-alpha stimulated HAECs ( 55.2 % and 65.6 % inhibitions , respectively ) but only GBE could *inhibit* the stimulated activator protein 1 activation ( 45.1 % inhibition , P < 0.05 ) . Negative_regulation TCF20 ARSA 14566053 1158698 Thus , *inhibits* Beta-catenin mediated [TCF] activity by preventing the formation of the Beta-catenin/TCF-4 complex . Negative_regulation TCF20 CCND1 11788592 916924 *represses* the basic helix-loop-helix [transcription factor] , BETA2/NeuroD . Negative_regulation TCF20 EPHB2 16818788 1581364 Blocking the activation of *prevented* histone phosphorylation and [transcription factor] binding to the IL-10 promoter . Negative_regulation TCF20 FOXO1 22550000 2669255 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced dependent *inhibition* of [Wnt/TCF] activity . Negative_regulation TCF20 IFI27 17113786 1677043 Overexpression of the prosensory [transcription factor] , Math1 , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation TCF20 NGFR 8408202 233271 In this system neurons but not other cell types , repress the expression of Schwann cell while *inducing* the expression of the POU domain [transcription factor] , suppressed cAMP inducible POU , and myelin P0 . Negative_regulation TCF20 TNF 12893683 1135180 Electrophoretic mobility shift assay demonstrated that both GBE and probucol inhibited [transcription factor] nuclear factor-kappaB activation in TNF-alpha stimulated HAECs ( 55.2 % and 65.6 % inhibitions , respectively ) but only GBE could *inhibit* the stimulated activator protein 1 activation ( 45.1 % inhibition , P < 0.05 ) . Negative_regulation TCF21 ARSA 14566053 1158699 Thus , *inhibits* Beta-catenin mediated [TCF] activity by preventing the formation of the Beta-catenin/TCF-4 complex . Negative_regulation TCF21 CCND1 11788592 916925 *represses* the basic helix-loop-helix [transcription factor] , BETA2/NeuroD . Negative_regulation TCF21 EPHB2 16818788 1581365 Blocking the activation of *prevented* histone phosphorylation and [transcription factor] binding to the IL-10 promoter . Negative_regulation TCF21 FOXO1 22550000 2669259 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced dependent *inhibition* of [Wnt/TCF] activity . Negative_regulation TCF21 IFI27 17113786 1677048 Overexpression of the prosensory [transcription factor] , Math1 , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation TCF21 NGFR 8408202 233273 In this system neurons but not other cell types , repress the expression of Schwann cell while *inducing* the expression of the POU domain [transcription factor] , suppressed cAMP inducible POU , and myelin P0 . Negative_regulation TCF21 TNF 12893683 1135182 Electrophoretic mobility shift assay demonstrated that both GBE and probucol inhibited [transcription factor] nuclear factor-kappaB activation in TNF-alpha stimulated HAECs ( 55.2 % and 65.6 % inhibitions , respectively ) but only GBE could *inhibit* the stimulated activator protein 1 activation ( 45.1 % inhibition , P < 0.05 ) . Negative_regulation TCF23 ARSA 14566053 1158703 Thus , *inhibits* Beta-catenin mediated [TCF] activity by preventing the formation of the Beta-catenin/TCF-4 complex . Negative_regulation TCF23 CCND1 11788592 916929 *represses* the basic helix-loop-helix [transcription factor] , BETA2/NeuroD . Negative_regulation TCF23 EPHB2 16818788 1581369 Blocking the activation of *prevented* histone phosphorylation and [transcription factor] binding to the IL-10 promoter . Negative_regulation TCF23 FOXO1 22550000 2669303 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced dependent *inhibition* of [Wnt/TCF] activity . Negative_regulation TCF23 IFI27 17113786 1677080 Overexpression of the prosensory [transcription factor] , Math1 , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation TCF23 NGFR 8408202 233281 In this system neurons but not other cell types , repress the expression of Schwann cell while *inducing* the expression of the POU domain [transcription factor] , suppressed cAMP inducible POU , and myelin P0 . Negative_regulation TCF23 TNF 12893683 1135190 Electrophoretic mobility shift assay demonstrated that both GBE and probucol inhibited [transcription factor] nuclear factor-kappaB activation in TNF-alpha stimulated HAECs ( 55.2 % and 65.6 % inhibitions , respectively ) but only GBE could *inhibit* the stimulated activator protein 1 activation ( 45.1 % inhibition , P < 0.05 ) . Negative_regulation TCF24 ARSA 14566053 1158705 Thus , *inhibits* Beta-catenin mediated [TCF] activity by preventing the formation of the Beta-catenin/TCF-4 complex . Negative_regulation TCF24 CCND1 11788592 916931 *represses* the basic helix-loop-helix [transcription factor] , BETA2/NeuroD . Negative_regulation TCF24 EPHB2 16818788 1581371 Blocking the activation of *prevented* histone phosphorylation and [transcription factor] binding to the IL-10 promoter . Negative_regulation TCF24 FOXO1 22550000 2669311 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced dependent *inhibition* of [Wnt/TCF] activity . Negative_regulation TCF24 IFI27 17113786 1677090 Overexpression of the prosensory [transcription factor] , Math1 , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation TCF24 NGFR 8408202 233285 In this system neurons but not other cell types , repress the expression of Schwann cell while *inducing* the expression of the POU domain [transcription factor] , suppressed cAMP inducible POU , and myelin P0 . Negative_regulation TCF24 TNF 12893683 1135194 Electrophoretic mobility shift assay demonstrated that both GBE and probucol inhibited [transcription factor] nuclear factor-kappaB activation in TNF-alpha stimulated HAECs ( 55.2 % and 65.6 % inhibitions , respectively ) but only GBE could *inhibit* the stimulated activator protein 1 activation ( 45.1 % inhibition , P < 0.05 ) . Negative_regulation TCF25 ARSA 14566053 1158704 Thus , *inhibits* Beta-catenin mediated [TCF] activity by preventing the formation of the Beta-catenin/TCF-4 complex . Negative_regulation TCF25 CCND1 11788592 916930 *represses* the basic helix-loop-helix [transcription factor] , BETA2/NeuroD . Negative_regulation TCF25 EPHB2 16818788 1581370 Blocking the activation of *prevented* histone phosphorylation and [transcription factor] binding to the IL-10 promoter . Negative_regulation TCF25 FOXO1 22550000 2669307 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced dependent *inhibition* of [Wnt/TCF] activity . Negative_regulation TCF25 IFI27 17113786 1677085 Overexpression of the prosensory [transcription factor] , Math1 , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation TCF25 NGFR 8408202 233283 In this system neurons but not other cell types , repress the expression of Schwann cell while *inducing* the expression of the POU domain [transcription factor] , suppressed cAMP inducible POU , and myelin P0 . Negative_regulation TCF25 TNF 12893683 1135192 Electrophoretic mobility shift assay demonstrated that both GBE and probucol inhibited [transcription factor] nuclear factor-kappaB activation in TNF-alpha stimulated HAECs ( 55.2 % and 65.6 % inhibitions , respectively ) but only GBE could *inhibit* the stimulated activator protein 1 activation ( 45.1 % inhibition , P < 0.05 ) . Negative_regulation TCF3 ARSA 14566053 1158700 Thus , *inhibits* Beta-catenin mediated [TCF] activity by preventing the formation of the Beta-catenin/TCF-4 complex . Negative_regulation TCF3 CCND1 11788592 916926 *represses* the basic helix-loop-helix [transcription factor] , BETA2/NeuroD . Negative_regulation TCF3 CCND1 22191569 2568776 BME treatment enhanced cellular tumor antigen p53 , cyclin dependent kinase inhibitor 1A ( also called p21 ) , and cyclic AMP dependent [transcription factor-3] levels and *inhibited* , D2 , and D3 , and mitogen activated protein kinase 8 ( also called Janus kinase ) expression , suggesting an additional mechanism involving cell cycle regulation and cell survival . Negative_regulation TCF3 EPHB2 16818788 1581366 Blocking the activation of *prevented* histone phosphorylation and [transcription factor] binding to the IL-10 promoter . Negative_regulation TCF3 FOXO1 22550000 2669263 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced dependent *inhibition* of [Wnt/TCF] activity . Negative_regulation TCF3 IFI27 17113786 1677053 Overexpression of the prosensory [transcription factor] , Math1 , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation TCF3 NGFR 8408202 233275 In this system neurons but not other cell types , repress the expression of Schwann cell while *inducing* the expression of the POU domain [transcription factor] , suppressed cAMP inducible POU , and myelin P0 . Negative_regulation TCF3 TNF 12893683 1135184 Electrophoretic mobility shift assay demonstrated that both GBE and probucol inhibited [transcription factor] nuclear factor-kappaB activation in TNF-alpha stimulated HAECs ( 55.2 % and 65.6 % inhibitions , respectively ) but only GBE could *inhibit* the stimulated activator protein 1 activation ( 45.1 % inhibition , P < 0.05 ) . Negative_regulation TCF4 ARSA 14566053 1158701 Thus , *inhibits* Beta-catenin mediated [TCF] activity by preventing the formation of the Beta-catenin/TCF-4 complex . Negative_regulation TCF4 CCND1 11788592 916927 *represses* the basic helix-loop-helix [transcription factor] , BETA2/NeuroD . Negative_regulation TCF4 EPHB2 16818788 1581367 Blocking the activation of *prevented* histone phosphorylation and [transcription factor] binding to the IL-10 promoter . Negative_regulation TCF4 FOXO1 22550000 2669267 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced dependent *inhibition* of [Wnt/TCF] activity . Negative_regulation TCF4 IFI27 17113786 1677058 Overexpression of the prosensory [transcription factor] , Math1 , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation TCF4 NGFR 8408202 233277 In this system neurons but not other cell types , repress the expression of Schwann cell while *inducing* the expression of the POU domain [transcription factor] , suppressed cAMP inducible POU , and myelin P0 . Negative_regulation TCF4 TNF 12893683 1135186 Electrophoretic mobility shift assay demonstrated that both GBE and probucol inhibited [transcription factor] nuclear factor-kappaB activation in TNF-alpha stimulated HAECs ( 55.2 % and 65.6 % inhibitions , respectively ) but only GBE could *inhibit* the stimulated activator protein 1 activation ( 45.1 % inhibition , P < 0.05 ) . Negative_regulation TCF7 ARSA 14566053 1158702 Thus , *inhibits* Beta-catenin mediated [TCF] activity by preventing the formation of the Beta-catenin/TCF-4 complex . Negative_regulation TCF7 CCND1 11788592 916928 *represses* the basic helix-loop-helix [transcription factor] , BETA2/NeuroD . Negative_regulation TCF7 EPHB2 16818788 1581368 Blocking the activation of *prevented* histone phosphorylation and [transcription factor] binding to the IL-10 promoter . Negative_regulation TCF7 FOXO1 22550000 2669271 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced dependent *inhibition* of [Wnt/TCF] activity . Negative_regulation TCF7 IFI27 17113786 1677063 Overexpression of the prosensory [transcription factor] , Math1 , in sensory epithelial precursor cells *induced* expression of myosin VIIa , espin , Brn3c , , and jagged2 , indicating differentiation to inner ear sensory cells . Negative_regulation TCF7 NGFR 8408202 233279 In this system neurons but not other cell types , repress the expression of Schwann cell while *inducing* the expression of the POU domain [transcription factor] , suppressed cAMP inducible POU , and myelin P0 . Negative_regulation TCF7 TNF 12893683 1135188 Electrophoretic mobility shift assay demonstrated that both GBE and probucol inhibited [transcription factor] nuclear factor-kappaB activation in TNF-alpha stimulated HAECs ( 55.2 % and 65.6 % inhibitions , respectively ) but only GBE could *inhibit* the stimulated activator protein 1 activation ( 45.1 % inhibition , P < 0.05 ) . Negative_regulation TCF7L2 AXIN2 10023673 590687 also *suppressed* Wnt-3a dependent activation of [Tcf-4] which binds to beta-catenin and acts as a transcription factor . Negative_regulation TCF7L2 AXIN2 20122174 2213271 The aim of this study was to investigate whether beta-catenin and/or p53 is required for *mediated* downregulation of [TCF-4] . Negative_regulation TCF7L2 AXIN2 20122174 2213276 These results suggest that does not *promote* p53 mediated downregulation of [TCF-4] . Negative_regulation TCF7L2 AXIN2 20122174 2213279 These results indicate that p53 is not required for *mediated* downregulation of [TCF-4] . Negative_regulation TCF7L2 AXIN2 20122174 2213282 Knock-down or inhibition of GSK-3beta prevented *mediated* downregulation of [TCF-4] . Negative_regulation TCF7L2 CCND1 18048388 1861126 Ectopic expression of Dkk3 in lung cancer cells with Dkk3 hypermethylation induced apoptosis and *inhibited* [TCF-4] activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and . Negative_regulation TCF7L2 CCND1 19089909 2030997 It also inhibited the transcriptional activities of [beta-catenin/TCF4] , and USF2 , and *inhibited* the expression of endogenous and TGFbeta2 . Negative_regulation TCF7L2 MMP28 23603903 2800108 Overexpression of [TCF4] , but not of TCF3 or LEF1 , *induced* MMP-1 , -3 , and -13 expression and generic activity in human chondrocytes . Negative_regulation TCF7L2 MMP7 23603903 2800123 Overexpression of [TCF4] , but not of TCF3 or LEF1 , *induced* MMP-1 , -3 , and -13 expression and generic activity in human chondrocytes . Negative_regulation TCHP IFI27 8654372 366888 Expression of Zta results in induction of the [tumor suppressor protein] , p53 , and the cyclin dependent kinase *inhibitors* , p21 and , as well as accumulation of hypophosphorylated pRb . Negative_regulation TCN1 AKT1 20489726 2327409 Thus , the results of our studies indicate that TCN-P binds to the PH domain of Akt and blocks its recruitment to the membrane , and that the subsequent inhibition of phosphorylation *contributes* to [TCN-P] antiproliferative and proapoptotic activities , suggesting that this drug may be beneficial to patients whose tumors express persistently phosphorylated Akt . Negative_regulation TCN1 AKT2 20489726 2327410 Thus , the results of our studies indicate that TCN-P binds to the PH domain of Akt and blocks its recruitment to the membrane , and that the subsequent inhibition of phosphorylation *contributes* to [TCN-P] antiproliferative and proapoptotic activities , suggesting that this drug may be beneficial to patients whose tumors express persistently phosphorylated Akt . Negative_regulation TCN1 AKT3 20489726 2327411 Thus , the results of our studies indicate that TCN-P binds to the PH domain of Akt and blocks its recruitment to the membrane , and that the subsequent inhibition of phosphorylation *contributes* to [TCN-P] antiproliferative and proapoptotic activities , suggesting that this drug may be beneficial to patients whose tumors express persistently phosphorylated Akt . Negative_regulation TCN1 CD1D 21272050 2403137 Thus , DNFB [Tc1] CS was significantly *impaired* in iNKT cell deficient ( -/- ) and Ja18 ( -/- ) mice , IL4Ra ( -/- ) and STAT-6 ( -/- ) mice , and also in pan B-cell deficient JH ( -/- ) mice . Negative_regulation TCN1 HAVCR2 19587053 2122620 expression correlates with a dysfunctional and senescent phenotype ( CD127 ( low ) CD57 ( high ) ) , a central rather than effector memory profile ( CD45RA ( negative ) CCR7 ( high ) ) , and *reduced* [Th1/Tc1] cytokine production . Negative_regulation TCN1 IFNG 18958887 1982876 Notably , the inhibitory effects of IL-4 on [Tc1] expression of VLA-4 could be *blocked* by the presence of IL-12 , but not . Negative_regulation TCN1 IGFBP1 8691111 372676 IGF-I stimulated [TC-1] DNA synthesis in a dose dependent manner and this effect was *inhibited* by recombinant and -4 . Negative_regulation TCN1 IGFBP4 8691111 372677 IGF-I stimulated [TC-1] DNA synthesis in a dose dependent manner and this effect was *inhibited* by recombinant . Negative_regulation TCN1 IL10 17640168 1771099 Black tea induced decrease in and TGF-beta of tumor cells *promotes* [Th1/Tc1] response in tumor bearer . Negative_regulation TCN1 IL12A 18958887 1982877 Notably , the inhibitory effects of IL-4 on [Tc1] expression of VLA-4 could be *blocked* by the presence of , but not IFN-gamma . Negative_regulation TCN1 IL12B 18958887 1982878 Notably , the inhibitory effects of IL-4 on [Tc1] expression of VLA-4 could be *blocked* by the presence of , but not IFN-gamma . Negative_regulation TCN1 IL15 11160248 781563 Overexpression of in vivo *enhances* [Tc1] response , which inhibits allergic inflammation in a murine model of asthma . Negative_regulation TCN1 IL15 11160248 781564 These results suggest that overexpression of in vivo suppresses Th2-mediated-allergic airway response via induction of CD8+ T cell *mediated* [Tc1] response . Negative_regulation TCN1 IL4 21272050 2403138 Thus , DNFB [Tc1] CS was significantly *impaired* in iNKT cell deficient CD1d ( -/- ) and Ja18 ( -/- ) mice , ( -/- ) and STAT-6 ( -/- ) mice , and also in pan B-cell deficient JH ( -/- ) mice . Negative_regulation TCN1 STAT6 21272050 2403136 Thus , DNFB [Tc1] CS was significantly *impaired* in iNKT cell deficient CD1d ( -/- ) and Ja18 ( -/- ) mice , IL4Ra ( -/- ) and ( -/- ) mice , and also in pan B-cell deficient JH ( -/- ) mice . Negative_regulation TDGF1P3 ITGB2 1673986 155029 A direct *role* for phosphorylation in the activation of [CR3] for phagocytosis is consistent with these data . Negative_regulation TEAD4 IGFBP1 22843786 2676997 Insulin prevented [RTEF-1] expression and significantly *inhibited* transcription in endothelial cells in a dose dependent fashion . Negative_regulation TECR CLDN10 24114540 2863673 Downregulation of by siRNA *resulted* in the decrease of SCC and PD , but not [TER] , in B4G12 cells . Negative_regulation TECR EPHB2 20593014 2285919 Inhibition of , not JNK , significantly *increased* [TER] and expression of claudin 4 in 2CLP monolayers , and prevented significant differences in claudin 18 expression between 2CLP and sham monolayers . Negative_regulation TECR FOXO1 24439372 2901536 Here , we show that , in the aging intestine of Drosophila , chronic activation of the transcription factor *reduces* expression of peptidoglycan recognition protein SC2 ( [PGRP-SC2] ) , a negative regulator of IMD/Relish innate immune signaling , and homolog of the anti-inflammatory molecules PGLYRP1-4 . Negative_regulation TECR ID1 10878025 722443 Ectopic overexpression of in the SCp2 nontumorigenic mammary epithelial cells , which does not undergo complete dexamethasone dependent tight junction reorganization , enhanced the dexamethasone induced ZO-1 tight junction localization and *stimulated* the monolayer [TER] . Negative_regulation TECR SLC9A2 18719001 1974949 In contrast to prior porcine studies , pharmacological inhibition of in postischemic tissues from wild-type mice also *resulted* in significant reductions in [TER] . Negative_regulation TECR TNF 10480548 643521 Overall , these results suggest that produced by HSILPF in response to LPS as a soluble form *cause* a decrease in the [TER] and loosening of tight junctions , and such early changes in the epithelial barrier may contribute to local inflammation in the gut . Negative_regulation TECR TNF 16530515 1536412 Both and IFN-gamma significantly *reduced* [TER] and increased epithelial permeability , effects prevented by ST/LA or BT. A Janus kinase (JAK) inhibitor synergistically potentiated effects of ST/LA or BT on TER and permeability , but p38 , ERK1 , 2 , or PI3K inhibition did not . Negative_regulation TECR TNF 18235000 1864339 *induced* a decrease in the [TER] of HCE cells in a concentration- and time dependent manner . Negative_regulation TECR TNF 19797215 2209138 Exposure to *induced* a continuous decline in [TER] that persisted for more than 20 hours . Negative_regulation TECR TNF 20824160 2318577 Co-treatment , as well pre-treatment , with forskolin plus rolipram prevented the *induced* decrease in [TER] . Negative_regulation TECR TNF 23383114 2739509 Moreover , down-regulation of caveolin-1 attenuated *induced* decrease in [TER] , increase in the flux of FITC-BSA and the disappearance of cortactin from the cell periphery in RPMVEC . Negative_regulation TEF TNF 23496259 2803949 However , *inhibited* the mRNA expression of the Per2 gene , as well as Dbp , Hlf , and [Tef] , but enhanced the mRNA expression of E4bp4 . Negative_regulation TERF1 F2R 15078882 1251900 Concomitant stimulation of both and PAR-4 in the presence of ADP scavengers still *resulted* in a strongly reduced activation of [Rap1B] . Negative_regulation TERF2 DGKI 15894621 1411619 regulates Ras guanyl releasing protein 3 and *inhibits* [Rap1] signaling . Negative_regulation TERF2 DGKI 15894621 1411650 We demonstrate that bound to RasGRP3 and *inhibited* its activation of [Rap1] by metabolizing DAG . Negative_regulation TERF2 F2R 15078882 1251902 Concomitant stimulation of both and PAR-4 in the presence of ADP scavengers still *resulted* in a strongly reduced activation of [Rap1B] . Negative_regulation TERF2 MAP2K6 17646383 1793312 The downregulation of [Rap1GAP] by Ras *required* the activation of the signal regulated kinase cascade and was correlated with the induction of mesenchymal morphology and migratory behavior . Negative_regulation TERF2IP DGKI 15894621 1411623 regulates Ras guanyl releasing protein 3 and *inhibits* [Rap1] signaling . Negative_regulation TERF2IP DGKI 15894621 1411652 We demonstrate that bound to RasGRP3 and *inhibited* its activation of [Rap1] by metabolizing DAG . Negative_regulation TERF2IP F2R 15078882 1251908 Concomitant stimulation of both and PAR-4 in the presence of ADP scavengers still *resulted* in a strongly reduced activation of [Rap1B] . Negative_regulation TERF2IP MAP2K6 17646383 1793326 The downregulation of [Rap1GAP] by Ras *required* the activation of the signal regulated kinase cascade and was correlated with the induction of mesenchymal morphology and migratory behavior . Negative_regulation TERT EPHB2 12223143 987662 HRT , VCR , and Vp16 could inhibit cell proliferation ( 0.28 % 0.08 % , 0.25 % 0.16 % , 0.24 % 0.11 % ) , induce apoptosis ( 21.12 % , 28.83 % , 12.30 % ) , *inhibit* [telomerase] activity , and down-regulate the protein expression of phosphorylated . Negative_regulation TERT EPHB2 12674761 1030438 The results showed that HRT , VCR and Vp16 could inhibit cell proliferation , induce apoptosis , *inhibit* [telomerase] activity and down-regulate the protein expression of phosphorylated . Negative_regulation TERT TNFSF10 23358473 2758701 In recent years , studies have shown that therapeutic agents such as metformin , salinomycin , DECA-14 , rapamycin , oncostatin M (OSM) , some natural compounds , oncolytic viruses , microRNAs , cell signaling pathway inhibitors , TNF related apoptosis inducing ligand ( ) , interferon ( IFN ) , [telomerase] *inhibitors* , all-trans retinoic acid ( ATRA ) and monoclonal antibodies can suppress the self-renewal of CSCs in vitro and in vivo . Negative_regulation TERT ZFP57 20145034 2214620 The *repression* of [telomerase] expression by artificial targeting the promoter region of the hTERT presents a new promising strategy for inhibiting the growth of human cancer cells . Negative_regulation TF ABCC6 8392910 225074 An increase in the number of epidermal growth factor and [transferrin] receptors ( EGFR , TrfR ) is *induced* by on these cells . Negative_regulation TF ACD 2224400 144377 [Transferrin] binding by erythroblasts was significantly *impaired* in compared to controls , although it tended to be reduced in all RA groups . Negative_regulation TF ALB 6087921 39929 Bovine *inhibits* binding of [transferrin] by hepatocytes in suspension by 60-70 % . Negative_regulation TF ALB 6087921 39930 Bovine *inhibits* low-affinity binding of [transferrin] ( 125000 molecules/cell ) , but has no effect on high-affinity binding ( 38000 molecules/cell ) . Negative_regulation TF ALB 8063401 268737 On Western strip blots , the binding of human [transferrin] to this protein was *blocked* by labelled human transferrin but not by , immunoglobulin G , or bovine transferrin or ovotransferrin . Negative_regulation TF APOB 6323541 36636 Furthermore , did not *prevent* the binding of [transferrin] to its receptor . Negative_regulation TF ARF1 22998223 2726731 Depletion of both Arf6 and abolishes G-clathrin , and *results* in partial inhibition of fast [transferrin] recycling consistent with the latter 's participation in this pathway . Negative_regulation TF ARF6 22998223 2726732 Depletion of both and Arf1 abolishes G-clathrin , and *results* in partial inhibition of fast [transferrin] recycling consistent with the latter 's participation in this pathway . Negative_regulation TF C9orf3 6297460 24627 Binding of 125I labelled diferric [transferrin] to cells was *inhibited* equally by either or diferric transferrin , but no inhibition was evident with apo-lactoferrin , iron saturated lactoferrin , or albumin . Negative_regulation TF CDK9 9465039 485978 Scatchard plots of these data indicate that the added substantially *reduced* the affinity of TfR for [transferrin] . Negative_regulation TF DHX9 4075694 54824 [Transferrin-125I] binding was *reduced* slightly by DFO and and increased by CHA . Negative_regulation TF EGF 1797590 176870 also *reduced* the transferrin ratio ( ED50 = 50 ng/ml ) as well as stimulating total [transferrin] secretion . Negative_regulation TF FGF1 6725271 38549 Insulin , liposomes , and were *required* for optimum growth in the serum-free medium , but removal of [transferrin] , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation TF FGF10 6725271 38550 Insulin , liposomes , and were *required* for optimum growth in the serum-free medium , but removal of [transferrin] , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation TF FGF11 6725271 38551 Insulin , liposomes , and were *required* for optimum growth in the serum-free medium , but removal of [transferrin] , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation TF FGF12 6725271 38552 Insulin , liposomes , and were *required* for optimum growth in the serum-free medium , but removal of [transferrin] , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation TF FGF13 6725271 38553 Insulin , liposomes , and were *required* for optimum growth in the serum-free medium , but removal of [transferrin] , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation TF FGF14 6725271 38554 Insulin , liposomes , and were *required* for optimum growth in the serum-free medium , but removal of [transferrin] , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation TF FGF16 6725271 38555 Insulin , liposomes , and were *required* for optimum growth in the serum-free medium , but removal of [transferrin] , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation TF FGF17 6725271 38556 Insulin , liposomes , and were *required* for optimum growth in the serum-free medium , but removal of [transferrin] , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation TF FGF18 6725271 38557 Insulin , liposomes , and were *required* for optimum growth in the serum-free medium , but removal of [transferrin] , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation TF FGF19 6725271 38558 Insulin , liposomes , and were *required* for optimum growth in the serum-free medium , but removal of [transferrin] , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation TF FGF2 6725271 38559 Insulin , liposomes , and were *required* for optimum growth in the serum-free medium , but removal of [transferrin] , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation TF FGF20 6725271 38560 Insulin , liposomes , and were *required* for optimum growth in the serum-free medium , but removal of [transferrin] , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation TF FGF21 6725271 38561 Insulin , liposomes , and were *required* for optimum growth in the serum-free medium , but removal of [transferrin] , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation TF FGF22 6725271 38562 Insulin , liposomes , and were *required* for optimum growth in the serum-free medium , but removal of [transferrin] , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation TF FGF23 6725271 38563 Insulin , liposomes , and were *required* for optimum growth in the serum-free medium , but removal of [transferrin] , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation TF FGF3 6725271 38564 Insulin , liposomes , and were *required* for optimum growth in the serum-free medium , but removal of [transferrin] , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation TF FGF4 6725271 38565 Insulin , liposomes , and were *required* for optimum growth in the serum-free medium , but removal of [transferrin] , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation TF FGF5 6725271 38566 Insulin , liposomes , and were *required* for optimum growth in the serum-free medium , but removal of [transferrin] , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation TF FGF6 6725271 38567 Insulin , liposomes , and were *required* for optimum growth in the serum-free medium , but removal of [transferrin] , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation TF FGF7 6725271 38568 Insulin , liposomes , and were *required* for optimum growth in the serum-free medium , but removal of [transferrin] , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation TF FGF8 6725271 38569 Insulin , liposomes , and were *required* for optimum growth in the serum-free medium , but removal of [transferrin] , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation TF FGF9 6725271 38570 Insulin , liposomes , and were *required* for optimum growth in the serum-free medium , but removal of [transferrin] , dexamethasone , or prostaglandin E1 had little effect on the growth rate . Negative_regulation TF HAMP 22560353 2696819 Here , we demonstrated for the first time that can significantly *inhibit* the expression of [transferrin receptor 1 (TfR1)] and divalent metal transporter 1 in addition to Fpn1 , and therefore reduce transferrin bound iron and non-transferrin bound iron uptake and also iron release in J774 macrophages . Negative_regulation TF HFE 11196670 762051 Kinetic analysis of receptor bound transferrin endocytosis reveals that expression not only *reduces* [transferrin] binding but also abrogates transferrin receptor endocytosis . Negative_regulation TF HFE 9546397 498723 binds to transferrin receptor (TfR) and *reduces* its affinity for iron loaded [transferrin] , implicating HFE in iron metabolism . Negative_regulation TF IFNG 3134021 94304 *reduced* [125I-transferrin] binding to WISH cells which are sensitive to its antiproliferative effect . Negative_regulation TF IL2 2571204 119205 Hence , CD4 positive T cells are the direct target of the suppressor cells , while inhibition of [transferrin] and interleukin-2 receptor expression on CD8 positive T cells *results* from reduced levels of in suppressor cell regulated cultures . Negative_regulation TF IL6ST 9465039 485979 Scatchard plots of these data indicate that the added substantially *reduced* the affinity of TfR for [transferrin] . Negative_regulation TF LTF 2333967 132632 Bovine competitively *inhibited* the binding of rat [transferrin] to the brush-border membrane vesicles . Negative_regulation TF LTF 8408013 233221 did not *inhibit* binding of [transferrin] , or vice versa . Negative_regulation TF MFI2 16111909 1454271 It includes serum [transferrin] , ovotransferrin , lactoferrin , , *inhibitor* of carbonic anhydrase , saxiphilin , the major yolk protein in sea urchins , the crayfish protein , pacifastin , and a protein from green algae . Negative_regulation TF MMP9 1379048 192728 Activated digested gelatin , type-V collagen , *reduced* carboxymethylated [transferrin] and , to a lesser extent , type-IV collagen and laminin A chain . Negative_regulation TF PACSIN2 15371016 1297413 Opposing *roles* of GS32 and in regulating the surface level of [transferrin receptor (TfR)] were observed . Negative_regulation TF SERPINA1 7506082 244379 We have previously shown that the hepatic acute-phase protein *inhibits* [transferrin (tf)] binding to its receptor ( tfR ) of human placental membranes . Negative_regulation TF SERPINA1 9365048 463079 completely *prevented* [transferrin] from binding to its receptor and internalization of the transferrin-transferrin receptor complex on HepG2 . Negative_regulation TF SNX4 17994011 1831427 Suppression of perturbs transport between these compartments and *causes* lysosomal degradation of the [transferrin receptor (TfnR)] . Negative_regulation TF TFPT 7738805 305695 *inhibited* the binding of 0.2 nM 125I labeled human diferric [transferrin] ( hTf ( Fe ) 2 ) to A431 cells with a inhibition constant ( Ki ) of 42 nM , whereas HSA-Pt did not . Negative_regulation TF TFR2 24639653 2925715 Loss of functional or its binding partner , the original HH protein , *results* in a loss of this [transferrin-sensitivity] . Negative_regulation TF TGFB1 2725526 113335 *had* no effect on transferrin production nor the ability of hormones to influence [transferrin] production . Negative_regulation TFAM PGC 23159434 2729674 Furthermore , the overexpression of induced by transfection largely *increased* the expression levels of NRF-1 and [TFAM] and significantly decreased the expression level of NF-?B in the cell senescence model . Negative_regulation TFAP2C TP63 18353300 1898430 AP-2 gamma is expressed in skin and previous research suggested a pathway where gene induction *results* in increased expression of [AP-2 gamma] , which in turn is responsible for induction of K14 . Negative_regulation TFF1 FHL1 19401155 2070363 Consistent with the results of the reporter assays , and RIP140 synergistically *inhibited* the transcription of the estrogen-responsive gene [pS2] . Negative_regulation TFF1 IL1B 12297725 991419 and IL6 *caused* a 3- to 11-fold reduction in [TFF] mRNA expression , displayed in real-time PCR . Negative_regulation TFF1 NR2F1 10620335 657458 TCDD inhibited estradiol ( E ( 2 ) ) -activated reporter gene activity from a consensus ERE and from the EREs in the [pS2] and Fos genes , and did not *block* the antiestrogenic activity of TCDD . Negative_regulation TFF2 IL1B 12297725 991421 and IL6 *caused* a 3- to 11-fold reduction in [TFF] mRNA expression , displayed in real-time PCR . Negative_regulation TFF3 IL1B 12297725 991423 and IL6 *caused* a 3- to 11-fold reduction in [TFF] mRNA expression , displayed in real-time PCR . Negative_regulation TFPI ARSA 9808710 545302 A cytochrome P450 inhibitor administered in the presence of did not *prevent* [15-epi-LXA4] formation , which suggests that P450 does not significantly contribute to formation of 15-epi-LXA4 in this murine model . Negative_regulation TFPI F3 2781520 119537 The recombinant [LACI] is recognized by polyclonal anti-LACI IgG , binds to factor Xa and *inhibits* VII ( a ) activity in a similar fashion as LACI purified from HepG2 cell conditioned media . Negative_regulation TFPI MMP28 21849050 2477471 Downregulation of [TFPI] also stimulated migration and invasion of cells , and elevated activity was *involved* in the increased invasion observed . Negative_regulation TFPI MMP7 21849050 2477486 Downregulation of [TFPI] also stimulated migration and invasion of cells , and elevated activity was *involved* in the increased invasion observed . Negative_regulation TFPI2 CD24 21984372 2526005 Over-expression of in A125 cells *resulted* in reduced [TFPI-2] expression and enhanced invasion . Negative_regulation TFPI2 HSP90AB1 10751404 698712 Mutation of Glu-651 and Asp-653 did not affect binding of FKBP52 or [PP5] but *inhibited* both Hop binding and chaperone activity . Negative_regulation TFPI2 S100A2 24068474 2909976 In the *presence* of ( 2+ ) , lower concentrations of suramin dose-dependently inhibited [PP5] activity as an S100 antagonist , whereas higher concentrations of suramin reactivated PP5 . Negative_regulation TFPI2 SCA18 24068474 2909978 In the *presence* of ( 2+ ) , lower concentrations of suramin dose-dependently inhibited [PP5] activity as an S100 antagonist , whereas higher concentrations of suramin reactivated PP5 . Negative_regulation TFPI2 SCA19 24068474 2909979 In the *presence* of ( 2+ ) , lower concentrations of suramin dose-dependently inhibited [PP5] activity as an S100 antagonist , whereas higher concentrations of suramin reactivated PP5 . Negative_regulation TFPI2 SCA20 24068474 2909981 In the *presence* of ( 2+ ) , lower concentrations of suramin dose-dependently inhibited [PP5] activity as an S100 antagonist , whereas higher concentrations of suramin reactivated PP5 . Negative_regulation TFPI2 SCA21 24068474 2909980 In the *presence* of ( 2+ ) , lower concentrations of suramin dose-dependently inhibited [PP5] activity as an S100 antagonist , whereas higher concentrations of suramin reactivated PP5 . Negative_regulation TFPI2 SCA22 24068474 2909982 In the *presence* of ( 2+ ) , lower concentrations of suramin dose-dependently inhibited [PP5] activity as an S100 antagonist , whereas higher concentrations of suramin reactivated PP5 . Negative_regulation TFPI2 SCA25 24068474 2909983 In the *presence* of ( 2+ ) , lower concentrations of suramin dose-dependently inhibited [PP5] activity as an S100 antagonist , whereas higher concentrations of suramin reactivated PP5 . Negative_regulation TFPI2 SCA26 24068474 2909984 In the *presence* of ( 2+ ) , lower concentrations of suramin dose-dependently inhibited [PP5] activity as an S100 antagonist , whereas higher concentrations of suramin reactivated PP5 . Negative_regulation TFPI2 SCA29 24068474 2909985 In the *presence* of ( 2+ ) , lower concentrations of suramin dose-dependently inhibited [PP5] activity as an S100 antagonist , whereas higher concentrations of suramin reactivated PP5 . Negative_regulation TFPI2 SCA30 24068474 2909986 In the *presence* of ( 2+ ) , lower concentrations of suramin dose-dependently inhibited [PP5] activity as an S100 antagonist , whereas higher concentrations of suramin reactivated PP5 . Negative_regulation TFPI2 SCA31 24068474 2909987 In the *presence* of ( 2+ ) , lower concentrations of suramin dose-dependently inhibited [PP5] activity as an S100 antagonist , whereas higher concentrations of suramin reactivated PP5 . Negative_regulation TFPI2 SCA32 24068474 2909988 In the *presence* of ( 2+ ) , lower concentrations of suramin dose-dependently inhibited [PP5] activity as an S100 antagonist , whereas higher concentrations of suramin reactivated PP5 . Negative_regulation TFPI2 SCA34 24068474 2909989 In the *presence* of ( 2+ ) , lower concentrations of suramin dose-dependently inhibited [PP5] activity as an S100 antagonist , whereas higher concentrations of suramin reactivated PP5 . Negative_regulation TFPI2 SCA37 24068474 2909990 In the *presence* of ( 2+ ) , lower concentrations of suramin dose-dependently inhibited [PP5] activity as an S100 antagonist , whereas higher concentrations of suramin reactivated PP5 . Negative_regulation TFPI2 SCA38 24068474 2909991 In the *presence* of ( 2+ ) , lower concentrations of suramin dose-dependently inhibited [PP5] activity as an S100 antagonist , whereas higher concentrations of suramin reactivated PP5 . Negative_regulation TFPI2 SCA9 24068474 2909977 In the *presence* of ( 2+ ) , lower concentrations of suramin dose-dependently inhibited [PP5] activity as an S100 antagonist , whereas higher concentrations of suramin reactivated PP5 . Negative_regulation TFPI2 SLPI 8882727 390902 Analysis of their N-terminal amino acid sequences demonstrated that the purified inhibitors were identical to the secreted forms of amyloid protein precursors (APPs) , tissue factor pathway inhibitor (TFPI) , [placental protein 5 (PP5)/TFPI-2] , and secretory leukocyte proteinase *inhibitor* ( ) . Negative_regulation TFPI2 SRC 21984372 2526007 The silencing of , similar to CD24 , was able to *enhance* [TFPI-2] expression and reduce tumor cell invasion . Negative_regulation TFPT TNF 14596819 1160343 Results indicated that [FB1] can *induce* CD95 modulated signaling when is absent . Negative_regulation TFRC IL1B 8250840 238017 [Transferrin-receptor] expression was *diminished* by TNF alpha and , but not IFN gamma , suggesting different effector mechanisms . Negative_regulation TFRC RNASE1 8877402 390512 BS significantly *inhibited* the expression of CD25 , CD38 and [CD71] antigens on PHA- , Con A- and MLC stimulated human T and B lymphocytes . Negative_regulation TFRC RNASE7 8877402 390520 BS significantly *inhibited* the expression of CD25 , CD38 and [CD71] antigens on PHA- , Con A- and MLC stimulated human T and B lymphocytes . Negative_regulation TFRC TF 20133674 2213467 Binding of HFt to [TfR1] is partially *inhibited* by diferric , but it is hindered little , if at all , by HFE . Negative_regulation TFRC TF 3298247 75232 By comparison , insulin stimulated hexose transport in 3T3-L1 adipocytes with a half-maximal effect at 8 nM and a half-time of 105 s. Scatchard analysis of 125I-transferrin binding to cells at 4 degrees C showed that the insulin induced increase in [transferrin receptor] binding was *due* to an increase in the number of surface receptors . Negative_regulation TFRC TF 7777590 309332 *reduces* the production of soluble [transferrin receptor] . Negative_regulation TFRC TF 9841879 552933 Furthermore , endocytosed transferrin-inhibitor conjugate could be recycled back to the extracellular medium and binding to the [transferrin receptor] could be *blocked* by native . Negative_regulation TFRC TNF 8250840 238015 [Transferrin-receptor] expression was *diminished* by and IL-1 beta , but not IFN gamma , suggesting different effector mechanisms . Negative_regulation TG CREB3L2 18757431 1956581 also *inhibited* 4-fold the expression of [thyroglobulin] , a native cAMP-responsive gene , in primary thyroid cells treated with thyroid stimulating hormone . Negative_regulation TG IL1B 7578850 290863 However , the nitrite production was unrelated to the induced *inhibition* of [thyroglobulin (Tg)] and cyclic AMP ( cAMP ) and the IL-1 beta induced IL-6 production . Negative_regulation TGFB1 ADRB2 11138844 760359 In summary , [TGF-beta1] *induces* desensitization through the alteration in adenylyl cyclase activity and down-regulation of beta2-adrenoceptor mRNA and protein through the reduction in the rate of beta2-adrenoceptor gene transcription . Negative_regulation TGFB1 ANGPT1 17085463 1685073 also *reduced* renal tissue levels of [transforming growth factor-beta1] ( TGF-beta1 ) , alpha-smooth muscle actin , fibronectin , as well as Smad 2/3 expression , but increased Smad 7 expression . Negative_regulation TGFB1 CCND1 7972105 280302 Overexpression of human *reduces* the [transforming growth factor beta] ( TGF-beta) type II receptor and growth inhibition by TGF-beta 1 in an immortalized human esophageal epithelial cell line . Negative_regulation TGFB1 CST6 17429295 1724073 Therefore , the *role* of in the pathogenesis of coronary artery ectasia and its potential interaction with [transforming growth factor-beta1] should be evaluated in further studies . Negative_regulation TGFB1 CTGF 16306131 1539375 Overexpression of during hepatic fibrogenesis is *induced* by [transforming growth factor (TGF)-beta] . Negative_regulation TGFB1 CTGF 19127219 2047792 Treatment with JNK inhibitors also decreased normal branching morphogenesis and induced expression as well as augmented [TGF-beta1] *inhibition* of branching and induction of CTGF expression . Negative_regulation TGFB1 EPHB2 12595493 1061585 *inhibited* MCP-1 and PAI-1 mRNA expression in MC , but not [TGF-beta1] . Negative_regulation TGFB1 EPHB2 18314002 1897494 Using dominant negative ( DN ) mutants for Erk , Jnk and p38 , we demonstrated that the expression of *caused* a significant inhibition of [TGF-beta1] induced CTGF promoter activity . Negative_regulation TGFB1 EPHB2 19778233 2141039 The induction of TNF-alpha and [TGF-beta1] by silica was *suppressed* by Src inhibitor ( PP1 ) , inhibitor ( PD98059 ) , but not by p38 kinase inhibitor ( SB203580 ) . Negative_regulation TGFB1 EPHB2 24157151 2859907 To investigate the pathway , end-plate chondrocytes were exposed to 10 ng/ml of [transforming growth factor beta 1] ( TGF-ß1 ) , TGF-ß1 siRNA , or a specific extracellular signalregulated kinase ( ) 1/2 *inhibitor* , U0126 , in addition to CMT . Negative_regulation TGFB1 IL1B 10433158 633930 Stimulation with ( 1 ng/mL ) or TNFalpha ( 1 ng/mL ) *resulted* in a significant increase in [TGFbeta1] mRNA expression after 48 hours : 2.7 and 2.1 times the control level , respectively . Negative_regulation TGFB1 IL1B 10547196 564712 Both IL-1alpha and *reduced* CD44 membrane expression of MIA PaCa 2 , while [TGF-beta1] increased the percentage of CD44 positive CAPAN-1 cells . Negative_regulation TGFB1 IL1B 15450530 1300744 IL-6 , but not OSM , reversed *induced* [TGF-beta1] inhibition . Negative_regulation TGFB1 IL1B 16253647 1471885 The release of [TGF-beta1] over 48 hours by adipose tissue explants was significantly enhanced in the *presence* of both the inhibitor of TNF-alpha and of . Negative_regulation TGFB1 IL1B 18611149 1979208 [TGF-beta1] up-regulated the expression of SZP in cultured explants , but *down-regulated* it . Negative_regulation TGFB1 IL1B 18611149 1979210 Real-time polymerase chain reaction analysis revealed that [TGF-beta1] significantly up-regulated SZP expression and that *down-regulated* it . Negative_regulation TGFB1 IL1B 19591943 2122823 Bacterial lipopolysaccharide (LPS) stimulated expression and *inhibited* that of the anti-inflammatory [TGF-beta1] , although it was ineffective on TNF-alpha and IL-6 . Negative_regulation TGFB1 IL1B 9885238 584517 Expansion of clonogenic tumor cells was seen in the *presence* of SCF + + IL-3 + IL-6 + EPO , but was suppressed by [TGF-beta1] . Negative_regulation TGFB1 IL1R2 17182252 1688326 gene transfer *reduced* intragraft monocytes/macrophages and CD4 ( + ) cell infiltrates ( p < 0.05 ) , TNF-alpha and [transforming growth factor-beta] ( TGF-beta ) expression ( p < 0.05 ) , and prolonged graft survival ( 15.6+/-5.7 vs 10.3+/-2.5 days with control vector and 10.1+/-2.1 days with buffer alone ; p < 0.01 ) . Negative_regulation TGFB1 ITGB2 16148944 1461283 Indeed , in neutrophil-macrophage cocultures , lack of on either cell type *leads* to dramatically reduced [TGF-beta1] release by macrophages due to defective adhesion to , and subsequent impaired phagocytic clearance of , neutrophils . Negative_regulation TGFB1 MMP28 18996114 2015952 Inhibition of activity *restored* [TGF-beta1] levels , suggesting an involvement of MMP activities in the down-regulation of TGF-beta1 by tamoxifen . Negative_regulation TGFB1 MMP7 18996114 2015967 Inhibition of activity *restored* [TGF-beta1] levels , suggesting an involvement of MMP activities in the down-regulation of TGF-beta1 by tamoxifen . Negative_regulation TGFB1 PECAM1 19729486 2147077 Confocal microscopy and real-time PCR showed that [transforming growth factor (TGF)-beta1] *induced* de novo expression of alpha-SMA and loss of expression of VE-cadherin and in MMECs and primary cultures of renal endothelial cells in a time- and dose dependent fashion . Negative_regulation TGFB1 PLAU 11983447 935625 Inhibition of delays expression of c-jun , *activated* [transforming growth factor beta 1] , and matrix metalloproteinase 2 during post-hepatectomy liver regeneration in mice . Negative_regulation TGFB1 PLAU 8126064 251287 The *role* of receptor bound ( uPA ) in cellular activation of latent [transforming growth factor-beta] ( LTGF-beta ) was investigated in a model system of mouse LB6 cells transfected with either a human uPA receptor cDNA ( LhuPAR+ ) , a human prouPA cDNA ( LhuPA ) , or a control neomycin-resistance cDNA ( Lneo ) . Negative_regulation TGFB1 TNF 10433158 633929 Stimulation with IL-1beta ( 1 ng/mL ) or ( 1 ng/mL ) *resulted* in a significant increase in [TGFbeta1] mRNA expression after 48 hours : 2.7 and 2.1 times the control level , respectively . Negative_regulation TGFB1 TNF 10644003 577706 Thus , tyrosinase activity and the rate of melanin formation in B16 melanocytes might reflect simply the balance between alpha-MSH stimulation and [TGF beta1] or *inhibition* , acting by independent mechanisms . Negative_regulation TGFB1 TNF 10903323 730702 *inhibits* [transforming growth factor-beta] /Smad signaling in human dermal fibroblasts via AP-1 activation . Negative_regulation TGFB1 TNF 11686517 875864 Moreover , we demonstrated that M. furfur modulates proinflammatory and immunomodulatory cytokine synthesis by downregulating IL-1alpha and by *inhibiting* IL-6 and and by upregulating IL-10 and [TGF-beta1] . Negative_regulation TGFB1 TNF 12733357 895603 could *enhance* the effect of high glucose on the secretion of [TGF-beta 1] , whereas insulin could inhibit it . Negative_regulation TGFB1 TNF 15479754 1354705 Importantly , PHA induced [TGFbeta1] production was significantly *enhanced* in AS patients compared with normal controls whereas the production of the pro-inflammatory cytokines and IFNgamma was reduced . Negative_regulation TGFB1 TNF 15970512 1423906 IFN-gamma and *inhibit* expression of [TGF-beta-1] , its receptors TBETAR-I and TBETAR-II in the corpus luteum of PMSG/hCG treated rhesus monkey . Negative_regulation TGFB1 TNF 16253647 1471884 The release of [TGF-beta1] over 48 hours by adipose tissue explants was significantly enhanced in the *presence* of both the inhibitor of and of IL-1 beta . Negative_regulation TGFB1 TNF 1730779 181311 stimulates DNA synthesis of mouse hepatocytes in primary culture and is *suppressed* by [transforming growth factor beta] and interleukin 6 . Negative_regulation TGFB1 TNF 18511845 1945191 Furthermore , and cJun *attenuated* [TGFbeta1] stimulation of rat Cyp7a1 . Negative_regulation TGFB1 TNF 8686743 370299 The expression of [transforming growth factor-beta1] , a potent fibrogenic factor , was *inhibited* by in the skin . Negative_regulation TGFB2 CCND1 7972105 280303 Overexpression of human *reduces* the [transforming growth factor beta] ( TGF-beta) type II receptor and growth inhibition by TGF-beta 1 in an immortalized human esophageal epithelial cell line . Negative_regulation TGFB2 CTGF 16306131 1539376 Overexpression of during hepatic fibrogenesis is *induced* by [transforming growth factor (TGF)-beta] . Negative_regulation TGFB2 IL1R2 17182252 1688327 gene transfer *reduced* intragraft monocytes/macrophages and CD4 ( + ) cell infiltrates ( p < 0.05 ) , TNF-alpha and [transforming growth factor-beta] ( TGF-beta ) expression ( p < 0.05 ) , and prolonged graft survival ( 15.6+/-5.7 vs 10.3+/-2.5 days with control vector and 10.1+/-2.1 days with buffer alone ; p < 0.01 ) . Negative_regulation TGFB2 PLAU 8126064 251288 The *role* of receptor bound ( uPA ) in cellular activation of latent [transforming growth factor-beta] ( LTGF-beta ) was investigated in a model system of mouse LB6 cells transfected with either a human uPA receptor cDNA ( LhuPAR+ ) , a human prouPA cDNA ( LhuPA ) , or a control neomycin-resistance cDNA ( Lneo ) . Negative_regulation TGFB2 TNF 10903323 730703 *inhibits* [transforming growth factor-beta] /Smad signaling in human dermal fibroblasts via AP-1 activation . Negative_regulation TGFB2 TNF 1730779 181312 stimulates DNA synthesis of mouse hepatocytes in primary culture and is *suppressed* by [transforming growth factor beta] and interleukin 6 . Negative_regulation TGFB3 CCND1 7972105 280304 Overexpression of human *reduces* the [transforming growth factor beta] ( TGF-beta) type II receptor and growth inhibition by TGF-beta 1 in an immortalized human esophageal epithelial cell line . Negative_regulation TGFB3 CTGF 16306131 1539377 Overexpression of during hepatic fibrogenesis is *induced* by [transforming growth factor (TGF)-beta] . Negative_regulation TGFB3 IL1R2 17182252 1688328 gene transfer *reduced* intragraft monocytes/macrophages and CD4 ( + ) cell infiltrates ( p < 0.05 ) , TNF-alpha and [transforming growth factor-beta] ( TGF-beta ) expression ( p < 0.05 ) , and prolonged graft survival ( 15.6+/-5.7 vs 10.3+/-2.5 days with control vector and 10.1+/-2.1 days with buffer alone ; p < 0.01 ) . Negative_regulation TGFB3 PLAU 8126064 251289 The *role* of receptor bound ( uPA ) in cellular activation of latent [transforming growth factor-beta] ( LTGF-beta ) was investigated in a model system of mouse LB6 cells transfected with either a human uPA receptor cDNA ( LhuPAR+ ) , a human prouPA cDNA ( LhuPA ) , or a control neomycin-resistance cDNA ( Lneo ) . Negative_regulation TGFB3 TNF 10903323 730704 *inhibits* [transforming growth factor-beta] /Smad signaling in human dermal fibroblasts via AP-1 activation . Negative_regulation TGFB3 TNF 1730779 181313 stimulates DNA synthesis of mouse hepatocytes in primary culture and is *suppressed* by [transforming growth factor beta] and interleukin 6 . Negative_regulation TGFBR2 IL1B 18053089 1983958 NFkappaB mediates *induced* down-regulation of [TbetaRII] through the modulation of Sp3 expression . Negative_regulation TGFBR2 TNF 14500687 1144237 *mediated* decrease of [TbetaRII] protein expression was not inhibited by the treatment of fibroblasts with either a selective inhibitor of I-kappaB-alpha phosphorylation , BAY 11-7082 , or a mitogen activated protein kinase/extracellular signal regulated kinase inhibitor , PD98059 . Negative_regulation TGFBR2 TNF 14500687 1144238 Calpain inhibitor I ( ALLN ) , a protease inhibitor , inhibits *mediated* down-regulation of [TbetaRII] . Negative_regulation TGFBR2 TNF 14500687 1144241 We found that *triggered* down-regulation of [TbetaRII] , leading to desensitization of human dermal fibroblasts toward TGF-beta . Negative_regulation TGM1 TGM2 7696177 287946 Analysis of additional tumor cell lines indicated that the expression of [transglutaminase I] and involucrin are under separate genetic control and that loss of activity can *result* either from a lack of protein or from a defect in the activation step . Negative_regulation TGM2 ADAM11 9219731 442436 In subsequent studies , melanoma cells were treated with a [transglutaminase] *inhibitor* , , which reduced the ability of adherent tumor cells to withstand the anti-adhesive effects of a subsequent increase in perfusate flow rate after the period of no-flow . Negative_regulation TGM2 ADH4 8541314 338657 Pyrazole , an inhibitor of , *prevented* the ethanol induced reduction in [transglutaminase] activity . Negative_regulation TGM2 ADH5 8541314 338658 Pyrazole , an inhibitor of , *prevented* the ethanol induced reduction in [transglutaminase] activity . Negative_regulation TGM2 ADH6 8541314 338659 Pyrazole , an inhibitor of , *prevented* the ethanol induced reduction in [transglutaminase] activity . Negative_regulation TGM2 ADH7 8541314 338660 Pyrazole , an inhibitor of , *prevented* the ethanol induced reduction in [transglutaminase] activity . Negative_regulation TGM2 CASP1 12667098 1075206 A discussion of the effect of antibodies , inhibitors , chemical *inhibitors* , heat-shock proteins , suppressor peptides and [transglutaminase] inhibitors upon aggregation and disease is presented . Negative_regulation TGM2 CASP10 12667098 1075207 A discussion of the effect of antibodies , inhibitors , chemical inhibitors , heat-shock proteins , suppressor peptides and [transglutaminase] *inhibitors* upon aggregation and disease is presented . Negative_regulation TGM2 CASP12 12667098 1075217 A discussion of the effect of antibodies , inhibitors , chemical inhibitors , heat-shock proteins , suppressor peptides and [transglutaminase] *inhibitors* upon aggregation and disease is presented . Negative_regulation TGM2 CASP14 12667098 1075208 A discussion of the effect of antibodies , inhibitors , chemical *inhibitors* , heat-shock proteins , suppressor peptides and [transglutaminase] inhibitors upon aggregation and disease is presented . Negative_regulation TGM2 CASP16 12667098 1075218 A discussion of the effect of antibodies , inhibitors , chemical *inhibitors* , heat-shock proteins , suppressor peptides and [transglutaminase] inhibitors upon aggregation and disease is presented . Negative_regulation TGM2 CASP2 12667098 1075209 A discussion of the effect of antibodies , inhibitors , chemical inhibitors , heat-shock proteins , suppressor peptides and [transglutaminase] *inhibitors* upon aggregation and disease is presented . Negative_regulation TGM2 CASP3 12667098 1075210 A discussion of the effect of antibodies , inhibitors , chemical inhibitors , heat-shock proteins , suppressor peptides and [transglutaminase] *inhibitors* upon aggregation and disease is presented . Negative_regulation TGM2 CASP4 12667098 1075211 A discussion of the effect of antibodies , inhibitors , chemical *inhibitors* , heat-shock proteins , suppressor peptides and [transglutaminase] inhibitors upon aggregation and disease is presented . Negative_regulation TGM2 CASP5 12667098 1075212 A discussion of the effect of antibodies , inhibitors , chemical inhibitors , heat-shock proteins , suppressor peptides and [transglutaminase] *inhibitors* upon aggregation and disease is presented . Negative_regulation TGM2 CASP6 12667098 1075213 A discussion of the effect of antibodies , inhibitors , chemical inhibitors , heat-shock proteins , suppressor peptides and [transglutaminase] *inhibitors* upon aggregation and disease is presented . Negative_regulation TGM2 CASP7 12667098 1075214 A discussion of the effect of antibodies , inhibitors , chemical *inhibitors* , heat-shock proteins , suppressor peptides and [transglutaminase] inhibitors upon aggregation and disease is presented . Negative_regulation TGM2 CASP8 12667098 1075215 A discussion of the effect of antibodies , inhibitors , chemical inhibitors , heat-shock proteins , suppressor peptides and [transglutaminase] *inhibitors* upon aggregation and disease is presented . Negative_regulation TGM2 CASP9 12667098 1075216 A discussion of the effect of antibodies , inhibitors , chemical *inhibitors* , heat-shock proteins , suppressor peptides and [transglutaminase] inhibitors upon aggregation and disease is presented . Negative_regulation TGM2 CD79A 6223074 28449 Because this phenomenon was inhibited by 0.1 % sodium azide and 100 microM dansylcadaverine , a [transglutaminase] *inhibitor* , Fc alpha complexes seemed to be released by an active process involving receptor movement . Negative_regulation TGM2 CNR1 12815050 1134365 Evidence that anandamide inhibits epidermal differentiation through receptor dependent *inhibition* of protein kinase C , activation protein-1 , and [transglutaminase] . Negative_regulation TGM2 CNR1 12815050 1134379 We also show that exogenous AEA inhibits the formation of cornified envelopes , a hallmark of keratinocyte differentiation , in HaCaT and NHEK cells treated with TPA plus calcium , through a *dependent* reduction of [transglutaminase] and protein kinase C activity . Negative_regulation TGM2 CSN2 12162571 972198 Tyrosine melanin inhibited tissue-type [transglutaminase] in a competitive manner with a glutamine substrate , and also *inhibited* the cross linking of catalyzed by a tissue-type transglutaminase . Negative_regulation TGM2 CSN3 12162571 972197 Tyrosine melanin inhibited tissue-type [transglutaminase] in a competitive manner with a glutamine substrate , and also *inhibited* the cross linking of catalyzed by a tissue-type transglutaminase . Negative_regulation TGM2 EDN1 19635990 2138087 The results showed that did not influence the basal transglutaminase activity of cardiomyocytes but significantly *inhibited* the 0.1-mmol/L Ca(2+) stimulated [transglutaminase] activity . Negative_regulation TGM2 EGF 21525012 2439796 We found that was highly active in the TRAIL-resistant cells , and suppression of EGFR dramatically *reduced* [TGM2] expression . Negative_regulation TGM2 EGF 8099784 220083 Calcium pretreatment *induces* the decrease in binding through the activation of [transglutaminase] in isolated liver membrane . Negative_regulation TGM2 EGF 8612508 353150 In contrast , membrane associated [transglutaminase] enzyme activity , which predominantly represents type 1 ( keratinocyte ) transglutaminase , is markedly *inhibited* by . Negative_regulation TGM2 ERBB2 22136669 2568497 TGA seem to enhance [TGM2] expression in both cell models , but PML expression was *induced* only in T84 enterocytes while GNA13 and were repressed in HUVEC endothelial cells , with several genes showing discordant effects in each model , highlighting the complexity of gene interactions in the pathogenesis of CD . Negative_regulation TGM2 F13A1 2879844 69546 GTP also inhibited rat liver and adult bovine aortic endothelial cell [transglutaminase] , but did not *inhibit* activity . Negative_regulation TGM2 GNA13 22136669 2568498 TGA seem to enhance [TGM2] expression in both cell models , but PML expression was *induced* only in T84 enterocytes while and ERBB2 were repressed in HUVEC endothelial cells , with several genes showing discordant effects in each model , highlighting the complexity of gene interactions in the pathogenesis of CD . Negative_regulation TGM2 GPI 4042460 52474 However , since the inhibition of NK activity in TG-M phi treated mice was relatively weak , and a substantial additional increase in metastases was observed in NK-depressed mice after transfusion of TG-M phi , it seems unlikely that the [TG-M] induced *inhibition* of NK reactivity is entirely responsible for the augmented formation of metastases . Negative_regulation TGM2 HDAC1 11501968 847258 On the basis of clinical and in vitro studies , the following mechanisms have been proposed to explain ATRA resistance : 1 ) induction of accelerated metabolism of ATRA , 2 ) increased expression of cellular retinoic acid binding proteins ( CRABPs ) , 3 ) constitutive degradation of PML-RAR alpha , 4 ) point mutations in the ligand binding domain of RAR alpha of PML-RAR alpha , 5 ) P-glycoprotein expression , 6 ) transcriptional *repression* by activity , 7 ) isoforms of PML-RAR alpha , 8 ) persistent telomerase activity , and 9 ) expression of type II [transglutaminase] . Negative_regulation TGM2 HDAC1 18003922 1827201 *Activation* of [tissue transglutaminase] transcription by inhibition as a therapeutic approach for Myc oncogenesis . Negative_regulation TGM2 HDAC10 11501968 847256 On the basis of clinical and in vitro studies , the following mechanisms have been proposed to explain ATRA resistance : 1 ) induction of accelerated metabolism of ATRA , 2 ) increased expression of cellular retinoic acid binding proteins ( CRABPs ) , 3 ) constitutive degradation of PML-RAR alpha , 4 ) point mutations in the ligand binding domain of RAR alpha of PML-RAR alpha , 5 ) P-glycoprotein expression , 6 ) transcriptional *repression* by activity , 7 ) isoforms of PML-RAR alpha , 8 ) persistent telomerase activity , and 9 ) expression of type II [transglutaminase] . Negative_regulation TGM2 HDAC10 18003922 1827199 *Activation* of [tissue transglutaminase] transcription by inhibition as a therapeutic approach for Myc oncogenesis . Negative_regulation TGM2 HDAC11 11501968 847257 On the basis of clinical and in vitro studies , the following mechanisms have been proposed to explain ATRA resistance : 1 ) induction of accelerated metabolism of ATRA , 2 ) increased expression of cellular retinoic acid binding proteins ( CRABPs ) , 3 ) constitutive degradation of PML-RAR alpha , 4 ) point mutations in the ligand binding domain of RAR alpha of PML-RAR alpha , 5 ) P-glycoprotein expression , 6 ) transcriptional *repression* by activity , 7 ) isoforms of PML-RAR alpha , 8 ) persistent telomerase activity , and 9 ) expression of type II [transglutaminase] . Negative_regulation TGM2 HDAC11 18003922 1827200 *Activation* of [tissue transglutaminase] transcription by inhibition as a therapeutic approach for Myc oncogenesis . Negative_regulation TGM2 HDAC2 11501968 847259 On the basis of clinical and in vitro studies , the following mechanisms have been proposed to explain ATRA resistance : 1 ) induction of accelerated metabolism of ATRA , 2 ) increased expression of cellular retinoic acid binding proteins ( CRABPs ) , 3 ) constitutive degradation of PML-RAR alpha , 4 ) point mutations in the ligand binding domain of RAR alpha of PML-RAR alpha , 5 ) P-glycoprotein expression , 6 ) transcriptional *repression* by activity , 7 ) isoforms of PML-RAR alpha , 8 ) persistent telomerase activity , and 9 ) expression of type II [transglutaminase] . Negative_regulation TGM2 HDAC2 18003922 1827202 *Activation* of [tissue transglutaminase] transcription by inhibition as a therapeutic approach for Myc oncogenesis . Negative_regulation TGM2 HDAC3 11501968 847260 On the basis of clinical and in vitro studies , the following mechanisms have been proposed to explain ATRA resistance : 1 ) induction of accelerated metabolism of ATRA , 2 ) increased expression of cellular retinoic acid binding proteins ( CRABPs ) , 3 ) constitutive degradation of PML-RAR alpha , 4 ) point mutations in the ligand binding domain of RAR alpha of PML-RAR alpha , 5 ) P-glycoprotein expression , 6 ) transcriptional *repression* by activity , 7 ) isoforms of PML-RAR alpha , 8 ) persistent telomerase activity , and 9 ) expression of type II [transglutaminase] . Negative_regulation TGM2 HDAC3 18003922 1827203 *Activation* of [tissue transglutaminase] transcription by inhibition as a therapeutic approach for Myc oncogenesis . Negative_regulation TGM2 HDAC4 11501968 847251 On the basis of clinical and in vitro studies , the following mechanisms have been proposed to explain ATRA resistance : 1 ) induction of accelerated metabolism of ATRA , 2 ) increased expression of cellular retinoic acid binding proteins ( CRABPs ) , 3 ) constitutive degradation of PML-RAR alpha , 4 ) point mutations in the ligand binding domain of RAR alpha of PML-RAR alpha , 5 ) P-glycoprotein expression , 6 ) transcriptional *repression* by activity , 7 ) isoforms of PML-RAR alpha , 8 ) persistent telomerase activity , and 9 ) expression of type II [transglutaminase] . Negative_regulation TGM2 HDAC4 18003922 1827194 *Activation* of [tissue transglutaminase] transcription by inhibition as a therapeutic approach for Myc oncogenesis . Negative_regulation TGM2 HDAC5 11501968 847255 On the basis of clinical and in vitro studies , the following mechanisms have been proposed to explain ATRA resistance : 1 ) induction of accelerated metabolism of ATRA , 2 ) increased expression of cellular retinoic acid binding proteins ( CRABPs ) , 3 ) constitutive degradation of PML-RAR alpha , 4 ) point mutations in the ligand binding domain of RAR alpha of PML-RAR alpha , 5 ) P-glycoprotein expression , 6 ) transcriptional *repression* by activity , 7 ) isoforms of PML-RAR alpha , 8 ) persistent telomerase activity , and 9 ) expression of type II [transglutaminase] . Negative_regulation TGM2 HDAC5 18003922 1827198 *Activation* of [tissue transglutaminase] transcription by inhibition as a therapeutic approach for Myc oncogenesis . Negative_regulation TGM2 HDAC6 11501968 847252 On the basis of clinical and in vitro studies , the following mechanisms have been proposed to explain ATRA resistance : 1 ) induction of accelerated metabolism of ATRA , 2 ) increased expression of cellular retinoic acid binding proteins ( CRABPs ) , 3 ) constitutive degradation of PML-RAR alpha , 4 ) point mutations in the ligand binding domain of RAR alpha of PML-RAR alpha , 5 ) P-glycoprotein expression , 6 ) transcriptional *repression* by activity , 7 ) isoforms of PML-RAR alpha , 8 ) persistent telomerase activity , and 9 ) expression of type II [transglutaminase] . Negative_regulation TGM2 HDAC6 18003922 1827195 *Activation* of [tissue transglutaminase] transcription by inhibition as a therapeutic approach for Myc oncogenesis . Negative_regulation TGM2 HDAC7 11501968 847254 On the basis of clinical and in vitro studies , the following mechanisms have been proposed to explain ATRA resistance : 1 ) induction of accelerated metabolism of ATRA , 2 ) increased expression of cellular retinoic acid binding proteins ( CRABPs ) , 3 ) constitutive degradation of PML-RAR alpha , 4 ) point mutations in the ligand binding domain of RAR alpha of PML-RAR alpha , 5 ) P-glycoprotein expression , 6 ) transcriptional *repression* by activity , 7 ) isoforms of PML-RAR alpha , 8 ) persistent telomerase activity , and 9 ) expression of type II [transglutaminase] . Negative_regulation TGM2 HDAC7 18003922 1827197 *Activation* of [tissue transglutaminase] transcription by inhibition as a therapeutic approach for Myc oncogenesis . Negative_regulation TGM2 HDAC8 11501968 847250 On the basis of clinical and in vitro studies , the following mechanisms have been proposed to explain ATRA resistance : 1 ) induction of accelerated metabolism of ATRA , 2 ) increased expression of cellular retinoic acid binding proteins ( CRABPs ) , 3 ) constitutive degradation of PML-RAR alpha , 4 ) point mutations in the ligand binding domain of RAR alpha of PML-RAR alpha , 5 ) P-glycoprotein expression , 6 ) transcriptional *repression* by activity , 7 ) isoforms of PML-RAR alpha , 8 ) persistent telomerase activity , and 9 ) expression of type II [transglutaminase] . Negative_regulation TGM2 HDAC8 18003922 1827193 *Activation* of [tissue transglutaminase] transcription by inhibition as a therapeutic approach for Myc oncogenesis . Negative_regulation TGM2 HDAC9 11501968 847253 On the basis of clinical and in vitro studies , the following mechanisms have been proposed to explain ATRA resistance : 1 ) induction of accelerated metabolism of ATRA , 2 ) increased expression of cellular retinoic acid binding proteins ( CRABPs ) , 3 ) constitutive degradation of PML-RAR alpha , 4 ) point mutations in the ligand binding domain of RAR alpha of PML-RAR alpha , 5 ) P-glycoprotein expression , 6 ) transcriptional *repression* by activity , 7 ) isoforms of PML-RAR alpha , 8 ) persistent telomerase activity , and 9 ) expression of type II [transglutaminase] . Negative_regulation TGM2 HDAC9 18003922 1827196 *Activation* of [tissue transglutaminase] transcription by inhibition as a therapeutic approach for Myc oncogenesis . Negative_regulation TGM2 INS 6137754 31114 Extrapancreatic action of sulfonylureas : hypoglycemic effects are not dependent on altered binding or *inhibition* of [transglutaminase] . Negative_regulation TGM2 INS 6137754 31121 Thus , the hypoglycemia caused by sulfonylurea administration could not be attributed to increases in insulin binding , *inhibition* of [transglutaminase] activity , or enhanced levels . Negative_regulation TGM2 IVL 7696177 287954 Analysis of additional tumor cell lines indicated that the expression of transglutaminase I and are under separate genetic control and that loss of [transglutaminase] activity can *result* either from a lack of protein or from a defect in the activation step . Negative_regulation TGM2 MMP14 11278623 811082 Overexpression of by glioma and fibrosarcoma cells *led* to proteolytic degradation of cell surface [tissue transglutaminase (tTG)] at the leading edge of motile cancer cells . Negative_regulation TGM2 MT-CO2 17618715 1787011 During the study period , the fertilization effect dominated ozone and climatic stresses ( temperature and precipitation ) , and the combination of these multiple factors *resulted* in net accumulation of [0.9Tg C] in this ecosystem . Negative_regulation TGM2 NA 15541757 1337287 Furthermore , these effects of DEP on either HO-1 or [TGM-2] were *reduced* by , thus suggesting that oxidative stress caused by this organic fraction of DEP may have induced these cellular responses . Negative_regulation TGM2 ODC1 10674181 578774 NA reduced tumor growth , *inhibited* the 12-O-tetradecanoylphorbol-13-acetate ( TPA ) induced activity , but induced the [transglutaminase] activity which was inhibited by TPA under different experimental conditions . Negative_regulation TGM2 ODC1 6125941 22208 Retinoids increase [transglutaminase] activity and *inhibit* activity in Chinese hamster ovary cells and in melanoma cells stimulated to differentiate . Negative_regulation TGM2 ODC1 7636843 317468 The biological activities associated with the RAR and RXR receptors were examined by testing representative examples with different receptor activation profiles for their ability to induce [tissue transglutaminase] ( Tgase ) activity in a human promyelocytic leukemia cell line ( HL-60 cdm-1 ) and to *inhibit* tumor-promoter induced activity in hairless mouse skin . Negative_regulation TGM2 PTPN22 23303819 2752500 did not *inhibit* [transglutaminase-2] activity , and incorporation of biotinyl-TVQQEL to fibrin was only weakly inhibited . Negative_regulation TGM2 RAC1 17680210 1842390 *role* of and FAK in the induction of [transglutaminase II] . Negative_regulation TGM2 RARA 7890733 299559 Overexpression of a truncated gene with dominant negative activity also *inhibited* the induction of [TGase II] expression . Negative_regulation TGM2 RPE65 19635990 2138086 The results showed that ET-1 did not influence the basal [transglutaminase] activity of cardiomyocytes but significantly *inhibited* the <0.1-mmol/L Ca(2+)> stimulated transglutaminase activity . Negative_regulation TGM2 TGFB1 1972706 135374 did not *enhance* the levels of the membrane bound Type I ( epidermal ) [transglutaminase] activity which is induced during squamous cell differentiation and did not increase Type II transglutaminase activity in differentiated NHEK cells . Negative_regulation TGM2 TGM1 7696177 287953 Analysis of additional tumor cell lines indicated that the expression of and involucrin are under separate genetic control and that loss of [transglutaminase] activity can *result* either from a lack of protein or from a defect in the activation step . Negative_regulation TGM2 TIMP2 16186358 1462298 One set of genes consistently upregulated in anterior segment tissues from different patients with PEX comprised latent transforming growth factor binding proteins ( LTBP-1 and -2 ) , which are structural components of elastic microfibrils , the cross linking enzyme [transglutaminase-2 (TGase-2)] , tissue *inhibitor* of matrix metalloproteinase-2 ( ) , A-kinase anchor protein-2 (AKAP-2) , apolipoprotein D , and the adenosine receptor-A3 (AdoR-A3) . Negative_regulation TGM2 TRNAE1 9582307 503896 The results of these experiments suggest that TGF-beta1 , BMP2 , and BMP4 regulation of mouse [tissue transglutaminase] gene expression *requires* a composite located in the 5'-flanking DNA . Negative_regulation TGM2 TYR 8103799 228989 RA , ddRA , 4-hydroxy RA , 4-oxo RA and 5,6-epoxy RA ( 10-100 nM ) reduced epidermal [transglutaminase] activity in human keratinocytes to similar extents , and *inhibited* alpha-melanocyte stimulating hormone-isobutylmethylxanthine-inducible activity in Cloudman S-91 mouse melanoma cells by 67 , 39 , 48 , 51 and 19 % , respectively , at 100 nM . Negative_regulation THBD ARSA 20877628 2326510 High dose , but not NCX 4016 , *inhibited* endothelial cell expression of VCAM-1 and [thrombomodulin] in the carotid arteries at 4 weeks after irradiation ; Negative_regulation THBD IL1B 8134908 242125 Endotoxin , and tumor necrosis factor alpha (TNF-alpha) dose-dependently increased the expression of tissue factor and at the same time *induced* [thrombomodulin] down-regulation on the surface of cultured bovine aortic endothelial cells . Negative_regulation THBD IL1B 8134908 242127 On the contrary , staurosporine , a highly potent , non-selective PKC inhibitor , simultaneously abolished tissue factor expression and [thrombomodulin] down-regulation *induced* by endotoxin , and TNF alpha . Negative_regulation THBD TNF 10602073 655222 induced EC expression and activity of MCP-1 and tissue factor and *suppressed* that of [thrombomodulin] on all substrates . Negative_regulation THBD TNF 10602073 655226 Basal expression of thrombomodulin was largely comparable for all three cell types grown on different surfaces , but *suppressed* [thrombomodulin] to different extents depending on the origin of the EC . Negative_regulation THBD TNF 1656544 166501 Pentoxifylline prevents *induced* suppression of endothelial cell surface [thrombomodulin] . Negative_regulation THBD TNF 16996955 1618041 Stimulation with *resulted* in physiologic upregulation of tissue factor and downregulation of [thrombomodulin] expression . Negative_regulation THBD TNF 1709310 155251 These agents prevented the interleukin I (IL-I) or *induced* decrease in [thrombomodulin] on HUVEC . Negative_regulation THBD TNF 1846763 153349 We conclude that acts primarily to *inhibit* [thrombomodulin] transcription . Negative_regulation THBD TNF 1847620 153484 Kinetic studies showed that for all stimuli the increase in tissue factor was transient , reaching a maximum after 4-8 h of preincubation with the stimulating agent and returning to normal values after 24 h . IL-1 and *induced* a time dependent decrease in [thrombomodulin] , by respectively 47 % and 67 % of control values after 24 h . Negative_regulation THBD TNF 2060425 162190 *suppresses* the endothelial anticoagulant cofactor [thrombomodulin] and induces expression of the procoagulant cofactor tissue factor . Negative_regulation THBD TNF 2555368 122020 In contrast to PMA , *reduced* [thrombomodulin] activity approximately 80 % with no change in thrombomodulin mRNA levels . Negative_regulation THBD TNF 8102337 225870 When measured in parallel , IL-4 and IL-13 counteracted [thrombomodulin] down-regulation *induced* by LPS , IL-1 or in endothelial cells . Negative_regulation THBD TNF 8134908 242124 Endotoxin , interleukin 1 beta (IL-1 beta) and dose-dependently *increased* the expression of tissue factor and at the same time induced [thrombomodulin] down-regulation on the surface of cultured bovine aortic endothelial cells . Negative_regulation THBD TNF 8134908 242126 On the contrary , staurosporine , a highly potent , non-selective PKC inhibitor , simultaneously abolished tissue factor expression and [thrombomodulin] down-regulation *induced* by endotoxin , IL1 beta and . Negative_regulation THBS1 CCND1 16705174 1560784 *repressed* ROCKII and [TSP-1] expression , and the migratory defect of cyclin D1 ( -/- ) cells was reversed by ROCK inhibition or TSP-1 immunoneutralizing antibodies . Negative_regulation THBS1 IL1B 9344505 459116 In a previous study , we showed that and TNF-alpha *inhibited* [thrombospondin-1 (TSP)] secretion by human umbilical vein endothelial cells . Negative_regulation THBS1 TNF 9344505 459115 In a previous study , we showed that IL-1beta and *inhibited* [thrombospondin-1 (TSP)] secretion by human umbilical vein endothelial cells . Negative_regulation THEM4 TNF 21282635 2393017 Both FFAs and *induce* an Akt inhibitor , [carboxyl-terminal modulator protein] ( CTMP ) . Negative_regulation THRA F2R 14597986 1161015 decreased by approximately 8 % ( p < 0.001 ) within 2 h after endotoxin infusion and stayed at those levels until 6 h. Concomitantly , [TRAP] *induced* P-selectin expression maximally decreased by 18 % ( p < 0.001 ) at 6 h . Negative_regulation THRAP3 F2R 14597986 1161019 decreased by approximately 8 % ( p < 0.001 ) within 2 h after endotoxin infusion and stayed at those levels until 6 h. Concomitantly , [TRAP] *induced* P-selectin expression maximally decreased by 18 % ( p < 0.001 ) at 6 h . Negative_regulation TIE1 ANGPT1 15370298 1297363 , but not Ang2 , *down-regulated* [Tie2] expression on HUVECs without TNF-alpha stimulation . Negative_regulation TIE1 ANGPT1 15370298 1297365 Both and Ang2 *attenuated* TNF-alpha induced [Tie2] up-regulation . Negative_regulation TIE1 ANGPT1 15381091 1298597 We show that can *inhibit* [Tie2] activation and can inhibit Ang1 activity in vitro and in vivo . Negative_regulation TIE1 ANGPT1 17544375 1751899 Autologous secretion of by transduced EC *resulted* in [Tie-2] activation and in the presence of SMC expressing VEGF resulted in coordinated sprouting in vitro and increase in flow and number of arteries in vivo . Negative_regulation TIE1 ANGPT1 17901375 1824153 sTie2 bound both and Ang2 and *inhibited* angiopoietin mediated [Tie2] phosphorylation and antiapoptosis . Negative_regulation TIE1 ANGPT1 19922791 2184717 This differential regulation of binding *allows* control of [Tie2] activation response to Ang1 without affecting Ang2 agonist activity and maintains the ability of Ang2 to antagonize even the enhanced Ang1 activation of Tie2 that occurs on loss of Tie1 ectodomain . Negative_regulation TIE1 ANGPT1 20060382 2205433 We found that [Tie2] receptor is expressed on macrophages and could *inhibit* LPS induced activation of macrophages , as evidenced by cell migration and TNF-alpha production , specifically through Tie2 receptor . Negative_regulation TIMP1 ANGPT1 10807867 692380 *suppressed* the secretion of tissue inhibitor of metalloproteinase-2 ( TIMP-2 ) , but not of [TIMP-1] . Negative_regulation TIMP1 CHI3L1 23663694 2784955 Enzyme linked immunosorbent assay ( ELISA ) was employed to measure levels of five serum proteins previously demonstrated to be up-regulated in papillary thyroid cancer (PTC) : angiopoietin-1 (Ang-1) , cytokeratin 19 (CK-19) , tissue *inhibitor* of metalloproteinase-1 ( [TIMP-1] ) , chitinase 3 like-1 ( ) , and galectin-3 (GAL-3) . Negative_regulation TIMP1 CLU 23747716 2828096 Kidney toxicity was investigated after 13 weeks of administering the complex orally to rats with parameters including blood urea nitrogen ( BUN ) , creatinine , and kidney damage biomarkers , beta-2-microglobulin ( ß2m ) , glutathione S-transferase alpha ( GST-a ) , kidney injury molecule 1 (KIM-1) , tissue *inhibitor* of matrix metalloproteinase 1 ( [TIMP-1] ) , vascular endothelial growth factor ( VEGF ) , calbindin , , cystatin C , neutrophil gelatinase associated lipocalin ( NGAL ) , and osteopontin . Negative_regulation TIMP1 CTGF 16596638 1550269 hCG *enhances* the expression and production of [TIMP-1] , whereas it downregulates the expression of and Mac25 . Negative_regulation TIMP1 CTGF 19375424 2106399 HSCs from Sprague-Dawley rats were exposed to leptin and expression of collagen-I , tissue *inhibitor* of matrix metalloproteinases-1 ( [TIMP1] ) , transforming growth factor beta1 ( TGF-beta1 ) , and connective tissue growth factor ( ) was assessed . Negative_regulation TIMP1 EPHB2 21600177 2435823 Western blot was used to detect the protein levels of MMP9 , prozymogen MMP9 ( pro-MMP9 ) , tissue *inhibitors* of metalloproteinases 1 ( [TIMP-1] ) , phosphorylated EGFR ( p-EGFR ) and phosphorylated external-signal regulated kinase ( ) . Negative_regulation TIMP1 IL1B 12527330 1048277 increased IL-6 , IL-8 , MIP-1beta , NO , PGE ( 2 ) and MMP-3 productions , but *inhibited* AGG and [TIMP-1] synthesis . Negative_regulation TIMP1 IL1B 17890880 1811208 TNF-alpha but not *resulted* in a dose dependent increase in the latent form of MMP-9 and a decrease in [TIMP-1] production . Negative_regulation TIMP1 IL1B 8403497 232316 *inhibited* [TIMP] production in endothelial cells while enhancing TIMP production in synovial cells and chondrocytes . Negative_regulation TIMP1 IL1B 8403497 232318 These results suggest that the cytokine effects on [TIMP] production are different among the different cell types , and that either or TNF-alpha *induce* cartilage matrix degradation by disrupting the collagenase/TIMP balance , while , on the other hand , IL-6 protects the tissue through an opposite effect . Negative_regulation TIMP1 IL1B 8591995 350628 [TIMP1] mRNA levels were only slightly *reduced* by ; Negative_regulation TIMP1 IL1B 9727371 529936 When the secretion of the regulatory inhibitors was examined , or TGF-beta1 both *resulted* in an increased secretion of [TIMP-I] , whereas the secretion of TIMP-II was downregulated . Negative_regulation TIMP1 MMP28 12904305 1143062 In a previous study , substitution of the second amino acid residue threonine for glycine in TIMP-1 , which confers selective MMP inhibition , was shown to obliterate its anti-apoptotic activity in activated hepatic stellate cells suggesting that the anti-apoptotic activity of [TIMP-1] is *dependent* on inhibition . Negative_regulation TIMP1 MMP28 15795420 1387185 Total collagen IV , the different alpha ( IV ) chains , matrix degrading metalloproteinases ( ) , and tissue *inhibitors* of metalloproteinases ( [TIMP] ) were quantified by immunocytochemistry and/or Western blotting . Negative_regulation TIMP1 MMP28 16113801 1448759 Here , we characterized the expression pattern of and their inhibitors , the tissue *inhibitors* of metalloproteases ( [TIMP] ) , in human and mouse lung development . Negative_regulation TIMP1 MMP28 17045020 1635632 OPN can protect against hyperoxia induced ALI by promoting the expression of [TIMP] and *inhibiting* the activation of . Negative_regulation TIMP1 MMP28 21033407 2181953 Metalloproteinases ( ) and their tissue *inhibitors* ( [TIMP] ) play a crucial role to keep the balance between the synthesis and degradation of extracellular matrix protein . Negative_regulation TIMP1 MMP28 22033229 2527386 This broader view reflects our emerging understanding that [TIMP] signaling and *inhibition* represent two important functions of TIMPs that have the potential to affect tissue pathology . Negative_regulation TIMP1 MMP28 24471121 2884688 Our results showed that the core protein of NIPP-1 peptide prevented fibril formation of type I collagen , elevated the level and *inhibited* [TIMP] production in a dose dependent manner . Negative_regulation TIMP1 MMP28 7933807 275409 The present study was designed to assess whether expression of mRNA for extracellular matrix (ECM) components , metalloproteinases ( ) and tissue *inhibitor* of metalloproteinases ( [TIMP] ) in glomeruli is affected by a low protein diet during the course of focal glomerulosclerosis (FGS) . Negative_regulation TIMP1 MMP28 8608454 352728 To understand the Mechanism of ECM induction and accumulation , the balance among neutral , tissue *inhibitor* of metalloproteinase ( [TIMP] ) and activator ( tissue plasminogen activator (tPA) ) following atherosclerosis and restenosis was measured in human normal artery , and native atherosclerotic and restenotic lesions . Negative_regulation TIMP1 MMP7 12904305 1143077 In a previous study , substitution of the second amino acid residue threonine for glycine in TIMP-1 , which confers selective MMP inhibition , was shown to obliterate its anti-apoptotic activity in activated hepatic stellate cells suggesting that the anti-apoptotic activity of [TIMP-1] is *dependent* on inhibition . Negative_regulation TIMP1 MMP7 15795420 1387200 Total collagen IV , the different alpha ( IV ) chains , matrix degrading metalloproteinases ( ) , and tissue *inhibitors* of metalloproteinases ( [TIMP] ) were quantified by immunocytochemistry and/or Western blotting . Negative_regulation TIMP1 MMP7 16113801 1448774 Here , we characterized the expression pattern of and their inhibitors , the tissue *inhibitors* of metalloproteases ( [TIMP] ) , in human and mouse lung development . Negative_regulation TIMP1 MMP7 17045020 1635647 OPN can protect against hyperoxia induced ALI by promoting the expression of [TIMP] and *inhibiting* the activation of . Negative_regulation TIMP1 MMP7 21033407 2181968 Metalloproteinases ( ) and their tissue *inhibitors* ( [TIMP] ) play a crucial role to keep the balance between the synthesis and degradation of extracellular matrix protein . Negative_regulation TIMP1 MMP7 21428178 2361466 To describe the enzymatic profile of plasma matrix metalloproteinases ( and -9 ) and tissue *inhibitors* of metalloproteinases ( [TIMP-1] and -2 ) in different categories of patients ( pts. ) with coronary artery disease ( CAD ) , and their relationship with clinical status , left ventricular ( LV ) function and remodelling . Negative_regulation TIMP1 MMP7 21854733 2546667 ( median 0.47 ng/ml ) , MMP-8 ( median 31.16 ng/ml ) and MMP-9 ( median 253.00 ng/ml ) levels were elevated and [TIMP-1] levels *suppressed* ( median 78.50 ng/ml ) in cardiac arrest patients as compared with healthy controls at 24h from ROSC . Negative_regulation TIMP1 MMP7 22033229 2527401 This broader view reflects our emerging understanding that [TIMP] signaling and *inhibition* represent two important functions of TIMPs that have the potential to affect tissue pathology . Negative_regulation TIMP1 MMP7 24471121 2884703 Our results showed that the core protein of NIPP-1 peptide prevented fibril formation of type I collagen , elevated the level and *inhibited* [TIMP] production in a dose dependent manner . Negative_regulation TIMP1 MMP7 7933807 275424 The present study was designed to assess whether expression of mRNA for extracellular matrix (ECM) components , metalloproteinases ( ) and tissue *inhibitor* of metalloproteinases ( [TIMP] ) in glomeruli is affected by a low protein diet during the course of focal glomerulosclerosis (FGS) . Negative_regulation TIMP1 MMP7 8608454 352743 To understand the Mechanism of ECM induction and accumulation , the balance among neutral , tissue *inhibitor* of metalloproteinase ( [TIMP] ) and activator ( tissue plasminogen activator (tPA) ) following atherosclerosis and restenosis was measured in human normal artery , and native atherosclerotic and restenotic lesions . Negative_regulation TIMP1 PLAU 12093135 960214 Northern blot analysis demonstrated that genes encoding urokinase type plasminogen activator ( ) , urokinase type plasminogen activator receptor ( uPAR ) , plasminogen activator inhibitor-1 ( PAI-1 ) , tissue *inhibitor* of metalloproteinases ( [TIMP-1] ) and c- myc were up-regulated in response to hyaluronan . Negative_regulation TIMP1 PLAU 1317222 187901 To investigate the role of tumor necrosis factor-alpha (TNF alpha) in advanced collagenolysis and degradation of connective tissue components in preterm parturition , the effects of human recombinant TNF alpha ( hrTNF alpha ) on the production of matrix metalloproteinase 1 (MMP-1)/tissue collagenase , MMP-3/stromelysin , tissue *inhibitor* of metalloproteinases ( [TIMP] ) , urokinase type-plasminogen activator ( ) and prostaglandin ( PG ) E2 in human chorionic cells were examined in vitro . Negative_regulation TIMP1 PLAU 18824345 2113752 ISL decreased EGF induced secretion of urokinase-type plasminogen activator ( ) , matrix metalloproteinase (MMP)-9 , tissue *inhibitor* of metalloproteinase-1 ( [TIMP-1] ) , and vascular endothelial growth factor ( VEGF ) , but increased TIMP-2 secretion in a concentration dependent manner . Negative_regulation TIMP1 PLAU 23560439 2777947 The MMP-9 activity was suppressed by these compounds through regulating urokinase-type plasminogen activator ( ) , tissue *inhibitor* of metalloproteinase ( [TIMP] ) -1 , plasminogen activator inhibitor (PAI)-1 , and PAI-2 ; Negative_regulation TIMP1 PLAU 9573532 502462 Compared with the untreated hypercholesterolemic group , antioxidant therapy *induced* significant reductions in renal mRNA levels for procollagen III ( to 60 % of untreated levels ) , collagen IV ( 60 % ) , and [TIMP-1] ( 20 % ) , while levels were significantly increased ( to 210 % ) . Negative_regulation TIMP1 SYNM 23485615 2771905 Reverse transcription polymerase chain reaction ( RT-PCR ) and western blot analyses revealed that CK inhibited *induced* increases in matrix metalloproteinase-13 (MMP-13) , tissue inhibitor of metalloproteinase-1 ( [TIMP-1] ) , and tumor necrosis factor-a (TNF-a) mRNA , and collagen type I and a-smooth muscle actin protein . Negative_regulation TIMP1 TLR7 23223421 2803377 This study demonstrates profibrotic properties of circulating monocytes from patients with SSc and a key *role* for signalling , particularly TLR8 , in [TIMP-1] secretion and matrix remodelling . Negative_regulation TIMP1 TNF 10197169 561076 Articular cartilage from multiparous rabbits showed a significant decrease in mRNA levels for relevant molecules such as type II collagen , biglycan , collagenase and tissue *inhibitors* of metalloproteinases ( [TIMP] ) -1 , as well as necrosis factor-alpha ( ) , inducible nitric oxide synthase (iNOS) and cyclo-oxygenase 2 (COX-2) . Negative_regulation TIMP1 TNF 12506070 1038328 The components of this MAP kinase pathway in the TM are dramatically affected by and inhibition of Erk 's phosphorylation *blocks* the changes in MMP and [TIMP] expression . Negative_regulation TIMP1 TNF 14500687 1144236 We showed that *prevents* TGF-beta induced gene trans activation , such as alpha2 ( I ) collagen or [tissue inhibitor of metalloproteinases 1] , and TGF-beta signaling pathways , such as Smad3 , c-Jun N-terminal kinase , and p38 mitogen activated protein kinases , without inducing levels of inhibitory Smad7 in human dermal fibroblasts . Negative_regulation TIMP1 TNF 15458430 1301531 Cotreatment with IL-1beta abolished the induction of MMP-9 but augmented the inhibition of [TIMP-1] in the *presence* of . Negative_regulation TIMP1 TNF 17890880 1811207 but not IL-1 beta *resulted* in a dose dependent increase in the latent form of MMP-9 and a decrease in [TIMP-1] production . Negative_regulation TIMP1 TNF 17890880 1811215 Co-treatment with IL-1 beta had no effect on the induction of MMP-9 but increased the inhibition of [TIMP-1] in the *presence* of . Negative_regulation TIMP1 TNF 17890880 1811216 Inhibition of PKC provided evidence of the importance of this pathway in mediating the *induced* suppression of [TIMP-1] . Negative_regulation TIMP1 TNF 21054185 2349362 Expression of MMP-3 increased and [TIMP-1] decreased in the *presence* of 10 ng/mL in ACBRI181 cells . Negative_regulation TIMP1 TNF 21199330 2493925 The mRNA levels of tumour necrosis factor (TNF)-a and protein levels of p38 , cytosolic phospolipase A2 and cyclooxygenase 2 were significantly increased in the D DSS ( + ) pups and were accompanied by a decrease in the protein level of tissue *inhibitor* of metalloproteinases ( [TIMP] ) 3 , a negative regulator of . Negative_regulation TIMP1 TNF 22245747 2605630 Serum group animals were used to measure porcine-specific tumour necrosis factor-alpha ( ) , interleukin ( IL-6 , IL-10 ) , matrix metalloproteinase ( MMP9 ) , Aquaporin-4 (AQP4) , tissue *inhibitor* to metalloproteinase-1 ( [TIMP1] ) , neuron-specific enolase (NSE) and S100B at 0.5 h , 6 h , 12 h , 24 h and 72h recovery by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TIMP1 TNF 8403497 232317 These results suggest that the cytokine effects on [TIMP] production are different among the different cell types , and that either IL-1 beta or *induce* cartilage matrix degradation by disrupting the collagenase/TIMP balance , while , on the other hand , IL-6 protects the tissue through an opposite effect . Negative_regulation TIMP1 TNF 8492010 219424 The results were as follows : 1 ) enhanced the production of MMPs and PGE2 and *suppressed* [TIMP] production . Negative_regulation TIMP2 ANGPT1 10807867 692381 *suppressed* the secretion of [tissue inhibitor of metalloproteinase-2] ( TIMP-2 ) , but not of TIMP-1 . Negative_regulation TIMP2 CTGF 18028129 1827921 In addition , the *mediated* reduction of [TIMP-2] activity and protein expression was prevented when ERK1/2 activation was inhibited by PD98059 . Negative_regulation TIMP2 MMP28 12194986 997829 The decrease in [TIMP-2] levels in the conditioned media was *prevented* by a broad spectrum inhibitor , suggesting that calcium promotes recruitment of TIMP-2 to MT1-MMP on the cell surface . Negative_regulation TIMP2 MMP28 16130185 1450046 Reverse zymography confirmed the bioactivity of ( matrix metalloproteinase ) *inhibition* of [TIMP-2] . Negative_regulation TIMP2 MMP7 12194986 997844 The decrease in [TIMP-2] levels in the conditioned media was *prevented* by a broad spectrum inhibitor , suggesting that calcium promotes recruitment of TIMP-2 to MT1-MMP on the cell surface . Negative_regulation TIMP2 MMP7 16130185 1450061 Reverse zymography confirmed the bioactivity of ( matrix metalloproteinase ) *inhibition* of [TIMP-2] . Negative_regulation TIMP2 MMP7 21428178 2361468 To describe the enzymatic profile of plasma matrix metalloproteinases ( and -9 ) and tissue *inhibitors* of metalloproteinases ( [TIMP-1 and -2] ) in different categories of patients ( pts. ) with coronary artery disease ( CAD ) , and their relationship with clinical status , left ventricular ( LV ) function and remodelling . Negative_regulation TIMP2 PLAU 15520187 1329006 Here we found that the expression of epiregulin , urokinase-type plasminogen activator ( ) , matrix metalloproteinase (MMP)14 , and tissue *inhibitor* of metalloproteinase ( [TIMP-2] ) were consistently and progressively up-regulated when viewed as a function of tumor stage in tissues of patients versus the metastatic potential seen in the mouse lung model . Negative_regulation TIMP2 TNF 21054185 2349363 Expression of MMP-1 increased and [TIMP-2] decreased in the *presence* of 10 ng/mL in ARPE-19 cells . Negative_regulation TIMP2 TNF 23266860 2741457 Inhibition of PKC-a activity also prevented *induced* MT1-MMP expression and proMMP-2 activation as well as down regulation of [TIMP-2] expression . Negative_regulation TIMP2 TNF 9543636 498199 [TIMP-2] levels are *reduced* by but not affected by the other treatments . Negative_regulation TIMP2 TNFSF10 16622457 1556730 Moreover , the expression of MMP-2 , its inhibitor [TIMP-2] and the tumour invasiveness related protein SPARC were effectively *inhibited* by in glioblastoma cell lines . Negative_regulation TIMP3 FOXO1 16690806 1584259 Silencing of using small interfering RNA oligonucleotides decreased IGFBP1 and DCN levels and *increased* CNR1 , [TIMP3] , and PRL levels . Negative_regulation TIMP3 IL1B 10217399 608391 Simultaneously , alpha almost completely *blocks* [TIMP-3] expression . Negative_regulation TIMP3 TNF 10217399 608390 Simultaneously , almost completely *blocks* [TIMP-3] expression . Negative_regulation TINF2 F2R 15078882 1251904 Concomitant stimulation of both and PAR-4 in the presence of ADP scavengers still *resulted* in a strongly reduced activation of [Rap1B] . Negative_regulation TJP1 ANGPT1 21772310 2509911 Compared with VEGF expression alone , coexpression of with VEGF *resulted* in upregulation of [tight junction protein] expression and reduction of Evans blue leakage ( AAV-ANG1/AAV-VEGF : 1.4 ± 0.3 versus AAV-VEGF : 2.8 ± 0.7 , P=0.001 ) . Negative_regulation TJP1 ARSA 15205571 1281175 Western blot revealed that *inhibited* [ZO-1] expression and LaLB with its spent culture supernatant counteracted this effect . Negative_regulation TJP1 ARSA 22917627 2683138 We measured whether *induced* the increase of differentiated Caco-2 permeability , the decrease of [tight junction protein] expression , the production of reactive oxygen species ( ROS ) , and the expression of ROS modified zonula occludens-1 (ZO-1) protein . Negative_regulation TJP1 ID1 10878025 722442 Ectopic overexpression of in the SCp2 nontumorigenic mammary epithelial cells , which does not undergo complete dexamethasone dependent tight junction reorganization , *enhanced* the dexamethasone induced [ZO-1] tight junction localization and stimulated the monolayer TER . Negative_regulation TJP1 IL1B 18848892 1994233 In the cultured leptomeningeal cells , and PGE ( 2 ) *caused* a marked loss of occludin and [ZO-1] , respectively . Negative_regulation TJP1 IL1B 20632386 2316657 Our results showed that GDNF resulted in a significant reduction in enhanced permeability , *inhibited* MPO activity , and TNF-alpha expression , and increased [ZO-1] and Akt expression . Negative_regulation TJP1 MMP28 19141539 2060924 Moreover , both and proteasome inhibitors *attenuated* HIV mediated altered expression of [ZO-1] . Negative_regulation TJP1 MMP7 19141539 2060939 Moreover , both and proteasome inhibitors *attenuated* HIV mediated altered expression of [ZO-1] . Negative_regulation TJP1 TNF 19278586 2046340 Furthermore , Western blotting showed that *reduced* [ZO-1] expression in a dose- and time dependent manner . Negative_regulation TJP1 TNF 19772664 2147492 The *roles* of in colon [tight junction protein] expression and intestinal mucosa structure in a mouse model of acute liver failure . Negative_regulation TJP1 TNF 20632386 2316656 Our results showed that GDNF resulted in a significant reduction in enhanced permeability , *inhibited* MPO activity , IL-1beta and expression , and increased [ZO-1] and Akt expression . Negative_regulation TJP1 TNF 23821192 2824746 SA3K nearly completely reversed *induced* disruptions of tight junctional [ZO-1] and subjacent adherens junctions VE-cadherin integrity . Negative_regulation TJP2 ANGPT1 21772310 2509912 Compared with VEGF expression alone , coexpression of with VEGF *resulted* in upregulation of [tight junction protein] expression and reduction of Evans blue leakage ( AAV-ANG1/AAV-VEGF : 1.4 ± 0.3 versus AAV-VEGF : 2.8 ± 0.7 , P=0.001 ) . Negative_regulation TJP2 ARSA 22917627 2683139 We measured whether *induced* the increase of differentiated Caco-2 permeability , the decrease of [tight junction protein] expression , the production of reactive oxygen species ( ROS ) , and the expression of ROS modified zonula occludens-1 (ZO-1) protein . Negative_regulation TJP2 TNF 19772664 2147493 The *roles* of in colon [tight junction protein] expression and intestinal mucosa structure in a mouse model of acute liver failure . Negative_regulation TJP3 ANGPT1 21772310 2509913 Compared with VEGF expression alone , coexpression of with VEGF *resulted* in upregulation of [tight junction protein] expression and reduction of Evans blue leakage ( AAV-ANG1/AAV-VEGF : 1.4 ± 0.3 versus AAV-VEGF : 2.8 ± 0.7 , P=0.001 ) . Negative_regulation TJP3 ARSA 22917627 2683140 We measured whether *induced* the increase of differentiated Caco-2 permeability , the decrease of [tight junction protein] expression , the production of reactive oxygen species ( ROS ) , and the expression of ROS modified zonula occludens-1 (ZO-1) protein . Negative_regulation TJP3 TNF 19772664 2147494 The *roles* of in colon [tight junction protein] expression and intestinal mucosa structure in a mouse model of acute liver failure . Negative_regulation TK1 TNF 8680797 337679 also *suppressed* [thymidine kinase] activity . Negative_regulation TK2 TNF 8680797 337680 also *suppressed* [thymidine kinase] activity . Negative_regulation TLN1 CAPN8 12490576 1033231 The goal of the present study was to determine the *role* of in changes in plasma membrane permeability and cytoskeleton associated paxillin , vinculin , [talin] , and alpha-actinin levels during acute renal cell death . Negative_regulation TLN2 CAPN8 12490576 1033245 The goal of the present study was to determine the *role* of in changes in plasma membrane permeability and cytoskeleton associated paxillin , vinculin , [talin] , and alpha-actinin levels during acute renal cell death . Negative_regulation TLR1 EPHB2 20802527 2375224 Together , these findings suggest that the new cancer associated ligand , PAUF , may activate TLR mediated signaling to produce the protumorigenic cytokines , but *inhibits* [TLR] mediated NF-?B signaling , thereby facilitating tumor growth and escape from innate immune surveillance . Negative_regulation TLR1 FAS 12469145 1032217 This finding suggests *mediated* apoptotic depletion of [TIL] in response to FasL expression in stomach cancers , and provides evidence to support the Fas counterattack theory as a mechanism of immune escape in gastric cancer . Negative_regulation TLR1 FAS 9605174 507577 Our findings suggest *mediated* apoptotic depletion of [TIL] in response to FasL expression by esophageal cancers , and provide the first direct , quantitative evidence to support the Fas counterattack as a mechanism of immune privilege in vivo in human cancer . Negative_regulation TLR1 IL1B 17467812 1737423 Inhibition of [TLR] *induced* production , which partially reversed the upregulation of RANKL induced by TLR ligands . Negative_regulation TLR1 TLR7 20578041 2315898 Upon axotomy , [TLR1] becomes strongly *induced* , while most other expression levels remain unaffected . Negative_regulation TLR10 EPHB2 20802527 2375232 Together , these findings suggest that the new cancer associated ligand , PAUF , may activate TLR mediated signaling to produce the protumorigenic cytokines , but *inhibits* [TLR] mediated NF-?B signaling , thereby facilitating tumor growth and escape from innate immune surveillance . Negative_regulation TLR10 IL1B 17467812 1737431 Inhibition of [TLR] *induced* production , which partially reversed the upregulation of RANKL induced by TLR ligands . Negative_regulation TLR2 EPHB2 20802527 2375225 Together , these findings suggest that the new cancer associated ligand , PAUF , may activate TLR mediated signaling to produce the protumorigenic cytokines , but *inhibits* [TLR] mediated NF-?B signaling , thereby facilitating tumor growth and escape from innate immune surveillance . Negative_regulation TLR2 IL1B 17467812 1737424 Inhibition of [TLR] *induced* production , which partially reversed the upregulation of RANKL induced by TLR ligands . Negative_regulation TLR2 S100B 21423669 2405935 Upon forming complexes with TLR2 ligands , *inhibited* [TLR2] via RAGE , through a paracrine epithelial cells/neutrophil circuit that restrained pathogen induced inflammation . Negative_regulation TLR2 TLR7 19648269 2125477 triggering on tolerogenic dendritic cells *results* in [TLR2] up-regulation and a reduced proinflammatory immune program . Negative_regulation TLR2 TNF 15664906 1365328 However , restimulation of MC with either PgLPS or EcLPS downregulates [TLR2] and TLR4 mRNA and protein and IL-1beta mRNA and *induces* a ca. 10-fold reduction in secretion , suggesting the induction of endotoxin tolerance by either LPS . Negative_regulation TLR2 TNF 16966997 1616134 Expression of HO-1 , [TLR2] , and TLR4 in monocytes was significantly *enhanced* in patients with severe SIRS compared with that in healthy volunteers , whereas intracellular expression with peptidoglycan was significantly decreased ( p < 0.05 ) in patients compared with that in healthy volunteers . Negative_regulation TLR2 TNF 17570324 1753740 Ketamine 2.5 , 5 and 10 mg/kg after CLP decreased intestinal level and NF-kappaB activity , and *inhibited* [TLR2] and TLR4 expressions as well . Negative_regulation TLR2 TNF 18261365 1839736 Ketamine at sub-anesthetic doses could suppress the production of inflammatory cytokines such as and IL-6 , attenuate NF-kappaB activity , and *inhibit* [TLR2] and TLR4 expression in polymicrobial sepsis . Negative_regulation TLR2 TNF 21396483 2453291 Artesunate not only inhibited and IL-6 release but also *inhibited* mRNA and protein expressions of [TLR2] and Nod2 , two important receptors , in murine peritoneal macrophages stimulated with heat killed WHO-2 , further demonstrating anti-inflammatory effect of artesunate was related to the inhibition of TLR2- and Nod2 mediated proinflammatory cytokines . Negative_regulation TLR2 TNF 24228579 2868700 Baicalin is able to specifically inhibit the expression of [TLR2/4-NOD2] , *inhibit* the expression of inflammatory factors IL-1beta , IL-6 and , and thereby reducing the injury of the tissue cells during the course of disease . Negative_regulation TLR3 EPHB2 20802527 2375226 Together , these findings suggest that the new cancer associated ligand , PAUF , may activate TLR mediated signaling to produce the protumorigenic cytokines , but *inhibits* [TLR] mediated NF-?B signaling , thereby facilitating tumor growth and escape from innate immune surveillance . Negative_regulation TLR3 IL1B 17467812 1737425 Inhibition of [TLR] *induced* production , which partially reversed the upregulation of RANKL induced by TLR ligands . Negative_regulation TLR3 TNF 20550948 2289937 Previously , we have shown that phenyl methimazole ( C10 ) markedly decreases virally induced [TLR-3] expression and signaling and potently *inhibits* both induced VCAM-1 expression and the resultant leukocyte-endothelial cell adhesion . Negative_regulation TLR4 BPI 17239348 1690523 Thus , we first show that *blocks* the [TLR4] responses by exogenous administration of BPI to lipid A-sensitive cells . Negative_regulation TLR4 BPI 22391182 2566588 However , either [TLR-4] expression or the cytokine levels significantly decreased in the *presence* of when platelets underwent LPS-challenge ( P < 0.05 ) , but still were higher than that in normal platelet group . Negative_regulation TLR4 CD14 16263085 1478652 Here , we found that membrane anchored is *required* for LPS induced downregulation of [TLR4] and MD-2 in CHO cells . Negative_regulation TLR4 CD14 20863319 2326003 Small molecules developed by our group are described that *inhibit* LPS stimulated [TLR4] activation by selectively targeting the interaction . Negative_regulation TLR4 CLU 22044067 2503739 By using a specific [Toll-like receptor 4 (TLR4)] signalling *inhibitor* , , as well as Myd88 inhibitory peptide , we have shown that DC activation by CNL is completely dependent on the TLR4 activation pathway . Negative_regulation TLR4 CLU 23076739 2729036 and D , an HBV and 5 µg/ml ( [TLR4] *inhibitor* ) group . Negative_regulation TLR4 CLU 24080332 2878659 Blockage of TLR-4 signaling by , a [TLR-4] *inhibitor* , completely inhibited the nickel induced ICAM-1 and IL-8 expression and NF?B activation . Negative_regulation TLR4 CLU 24662749 2930603 The results showed that LPS significantly increased MCP-1 and TLR4 expression and MCP-1 secretion in 3T3-L1 adipocytes , and that the MCP-1 expression was blocked by a [TLR4] *inhibitor* ( ) . Negative_regulation TLR4 EPHB2 20802527 2375227 Together , these findings suggest that the new cancer associated ligand , PAUF , may activate TLR mediated signaling to produce the protumorigenic cytokines , but *inhibits* [TLR] mediated NF-?B signaling , thereby facilitating tumor growth and escape from innate immune surveillance . Negative_regulation TLR4 EPHB2 22743248 2644394 Our flow cytometry and Western blot data showed that paclitaxel activated [TLR4-MyD88-ERK] signaling and that IS treatment could effectively *inhibit* this paclitaxel induced activation of signaling . Negative_regulation TLR4 IL1B 15509550 1328040 The *role* of in direct and [toll-like receptor 4-mediated] neutrophil activation and survival . Negative_regulation TLR4 IL1B 17467812 1737426 Inhibition of [TLR] *induced* production , which partially reversed the upregulation of RANKL induced by TLR ligands . Negative_regulation TLR4 LBP 22535680 2696811 The inhibitory peptide did selectively *reduce* activation of [TLR4] signaling via the IRF-3/MyD88 independent pathway . Negative_regulation TLR4 TNF 12923493 1131149 significantly *down-regulated* [TLR-4] mRNA expression after 6 h ( 100 % vs. 38.5 % +/- 4 % ; Negative_regulation TLR4 TNF 16965747 1616043 HXR could down-regulate the expression of membrane receptor [TLR4] and *inhibit* the expressions of NF-kappaB and . Negative_regulation TLR4 TNF 16965747 1616049 QGHXR can protect liver cells by down regulating the expressions of CD14 , [TLR(4)] and NF-kappaB and *inhibiting* expression . Negative_regulation TLR4 TNF 16966997 1616135 Expression of HO-1 , TLR2 , and [TLR4] in monocytes was significantly *enhanced* in patients with severe SIRS compared with that in healthy volunteers , whereas intracellular expression with peptidoglycan was significantly decreased ( p < 0.05 ) in patients compared with that in healthy volunteers . Negative_regulation TLR4 TNF 17570324 1753743 Ketamine 2.5 , 5 and 10 mg/kg after CLP decreased intestinal level and NF-kappaB activity , and *inhibited* TLR2 and [TLR4] expressions as well . Negative_regulation TLR4 TNF 18261365 1839740 Ketamine at sub-anesthetic doses could suppress the production of inflammatory cytokines such as and IL-6 , attenuate NF-kappaB activity , and *inhibit* TLR2 and [TLR4] expression in polymicrobial sepsis . Negative_regulation TLR4 TNF 19106809 2093285 *inhibits* [toll-like receptor 4] expression on monocytic cells via tristetraprolin during cardiopulmonary bypass . Negative_regulation TLR4 TNF 19106809 2093312 TTP expression and mitogen activated protein kinase signaling pathways play critical roles in CPB- and *mediated* decreases of [TLR4] on monocytes . Negative_regulation TLR4 TNF 20128155 2178927 The expression of TLR4 , and IL-6 in the myocardium significantly *increased* in the MI group and simvastatin markedly inhibits the expression of [TLR4] , TNF-alpha , and IL-6 in the myocardium after MI. Serum TNF-alpha and IL-6 levels between the MI group and the simvastatin group remained unchanged . Negative_regulation TLR4 TNF 21349589 2399578 Stimulation of endothelial monolayers with *resulted* in significant increase of [toll-like receptor 4] , interleukin-6 and -8 , and intercellular adhesion molecule-1 and vascular cellular adhesion molecule-1 gene expression in a time dependent manner . Negative_regulation TLR4 TNF 23568774 2804190 Rifampin *blocked* [TLR4] signaling induced by LPS , including NF-?B activation and the overproduction of proinflammatory mediators nitric oxide , interleukin 1ß , and a in mouse microglia BV-2 cells and macrophage RAW 264.7 cells . Negative_regulation TLR4 TNF 24334457 2894932 CORM-2 decreased systemic inflammatory cytokines , suppressed systemic and pancreatic macrophage secretion , and *inhibited* macrophage [TLR4] receptor complex expression . Negative_regulation TLR4 TNF 24345260 2880876 Triptolide can ameliorate LPS induced ALI by reducing the release of the inflammatory mediator and *inhibiting* [TLR4] expression . Negative_regulation TLR5 EPHB2 20802527 2375228 Together , these findings suggest that the new cancer associated ligand , PAUF , may activate TLR mediated signaling to produce the protumorigenic cytokines , but *inhibits* [TLR] mediated NF-?B signaling , thereby facilitating tumor growth and escape from innate immune surveillance . Negative_regulation TLR5 IL1B 17467812 1737427 Inhibition of [TLR] *induced* production , which partially reversed the upregulation of RANKL induced by TLR ligands . Negative_regulation TLR6 EPHB2 20802527 2375233 Together , these findings suggest that the new cancer associated ligand , PAUF , may activate TLR mediated signaling to produce the protumorigenic cytokines , but *inhibits* [TLR] mediated NF-?B signaling , thereby facilitating tumor growth and escape from innate immune surveillance . Negative_regulation TLR6 IL1B 17467812 1737432 Inhibition of [TLR] *induced* production , which partially reversed the upregulation of RANKL induced by TLR ligands . Negative_regulation TLR7 ACE 24251781 2903473 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , PI3K/AkT inhibition , IKK/JNK inhibition , mTORC1 inhibition , JAK/STAT inhibition , [TLR] suppression , and *inhibition* . Negative_regulation TLR7 ADORA2A 19494284 2091553 Differential expression of adenosine A3 receptors controls *mediated* inhibition of [TLR] responses in microglia . Negative_regulation TLR7 AKT1 24251781 2903475 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , *inhibition* , IKK/JNK inhibition , mTORC1 inhibition , JAK/STAT inhibition , [TLR] suppression , and ACE inhibition . Negative_regulation TLR7 AKT2 24251781 2903476 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , *inhibition* , IKK/JNK inhibition , mTORC1 inhibition , JAK/STAT inhibition , [TLR] suppression , and ACE inhibition . Negative_regulation TLR7 AKT3 24251781 2903477 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , *inhibition* , IKK/JNK inhibition , mTORC1 inhibition , JAK/STAT inhibition , [TLR] suppression , and ACE inhibition . Negative_regulation TLR7 ANPEP 23401034 2771018 [Toll-like receptor (TLR)] ligand induced IFN-? production was *diminished* by while it had no influence on NK-cell cytotoxicity . Negative_regulation TLR7 BCAP29 22187458 2537254 The ability of to *inhibit* [TLR] responses requires its capacity to bind PI3K . Negative_regulation TLR7 BCAP31 22187458 2537253 The ability of to *inhibit* [TLR] responses requires its capacity to bind PI3K . Negative_regulation TLR7 BTK 17520285 1857959 Our results do not indicate the essential *role* of in [TLR] signaling and DC development . Negative_regulation TLR7 BTK 20634142 2316738 Bruton's tyrosine kinase (Btk) has been reported to mediate signaling through toll-like receptors ( TLRs ) in many cell types , however , the *role* of in [TLR] activation of neutrophils remains unclear . Negative_regulation TLR7 CAMP 17041145 1649265 The anti-microbial peptide *inhibits* the activation of dendritic cells by [TLR] ligands . Negative_regulation TLR7 CAMP 17041145 1649275 In conclusion , we demonstrate that the anti-microbial peptide *inhibits* the activation of DCs by [TLR] ligands . Negative_regulation TLR7 CASP1 17360653 1712786 However , we found that Mal was cleaved by and that inhibition of caspase-1 activity *blocked* TLR2- and TLR4 mediated NF-kappaB and p38 MAP kinase activation but not IL-1 or [TLR7] signaling , which are Mal independent . Negative_regulation TLR7 CD200 22615569 2603882 We therefore hypothesize that ligation *suppresses* [TLR7] responses and that release of this inhibition enlarges sex differences in TLR7 signaling . Negative_regulation TLR7 CD200 22615569 2603883 This hypothesis is supported by our findings that in vivo administration of synthetic TLR7 ligand leads to enhanced type I IFN production , particularly in female Cd200 ( -/- ) mice and that ligation *inhibits* [TLR7] signaling in vitro . Negative_regulation TLR7 CD44 17277154 1697844 In this study , we examined the *role* of in acute pulmonary inflammation and in the regulation of [LPS-TLR] signaling . Negative_regulation TLR7 CD80 22231652 2636572 Most [toll-like receptor (TLR)] ligands *induced* comparable upregulation of co-stimulatory molecules CD40 , CD86 and B7H1 on young and aged cDC , whereas TLR2 and TLR5 stimulation resulted in reduced upregulation of and CD86 on aged cDC in vitro . Negative_regulation TLR7 CD86 22231652 2636573 Most [toll-like receptor (TLR)] ligands *induced* comparable upregulation of co-stimulatory molecules CD40 , CD86 and B7H1 on young and aged cDC , whereas TLR2 and TLR5 stimulation resulted in reduced upregulation of CD80 and on aged cDC in vitro . Negative_regulation TLR7 CHUK 24251781 2903471 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , PI3K/AkT inhibition , *inhibition* , mTORC1 inhibition , JAK/STAT inhibition , [TLR] suppression , and ACE inhibition . Negative_regulation TLR7 CISH 15491991 1347387 Here we have elucidated the nature of the regulatory *role* of in [TLR] signaling . Negative_regulation TLR7 CREM 17579082 1763895 Negative regulation of [TLR] responses by the neuropeptide CGRP is *mediated* by the transcriptional repressor . Negative_regulation TLR7 CSF3 20064484 2212122 mediated STAT3 phosphorylation and *inhibition* of [TLR] agonist induced cytokine production were prevented by pretreatment of cells with AG-490 ( JAK2 inhibitor ) . Negative_regulation TLR7 DAP 18081038 1847241 In this report , we demonstrate that both and the FcepsilonRIgamma-chain (FcRgamma) are *required* for negative regulation of [TLR] responses in bone marrow derived dendritic cells ( DC ) . Negative_regulation TLR7 EPHB2 20802527 2375229 Together , these findings suggest that the new cancer associated ligand , PAUF , may activate TLR mediated signaling to produce the protumorigenic cytokines , but *inhibits* [TLR] mediated NF-?B signaling , thereby facilitating tumor growth and escape from innate immune surveillance . Negative_regulation TLR7 FCER1G 18081038 1847242 In this report , we demonstrate that both DAP12 and the are *required* for negative regulation of [TLR] responses in bone marrow derived dendritic cells ( DC ) . Negative_regulation TLR7 GFI1 20547752 2295896 Here , we analyzed the *role* of the nuclear in the [TLR] response using primary bone marrow derived macrophages . Negative_regulation TLR7 GRK5 22078319 2528409 Together , our results demonstrate multiple *roles* of in [TLR] signaling . Negative_regulation TLR7 IAPP 23962980 2832023 *inhibits* [Toll-like receptor (TLR)] signaling , such as that of TLR4 in response to its ligand lipopolysaccharide (LPS) , as well as cytokine responses by coupling to TREM2 ( triggering receptor expressed on myeloid cells 2 ) at the plasma membrane . Negative_regulation TLR7 IARS 21340621 2420420 We explored the effects of CL097 ( TLR7/8 agonist ) and immunoregulatory sequence 661 ( , [TLR7] *inhibitor* ) on bone marrow derived dendritic cells ( BMDCs ) , diabetogenic CD8 ( + ) T cell function and autoimmune diabetes onset in NOD and 8.3 NOD T cell receptor transgenic mice ( 8.3 NOD mice ) . Negative_regulation TLR7 IARS 22896636 2666504 TLR7 antagonist could , in addition , *inhibit* [TLR13] signaling and reduced recognition of whole Gram positive bacteria by DCs , also in the absence of TLR7 . Negative_regulation TLR7 IKBKB 24251781 2903479 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , PI3K/AkT inhibition , *inhibition* , mTORC1 inhibition , JAK/STAT inhibition , [TLR] suppression , and ACE inhibition . Negative_regulation TLR7 IKBKG 24251781 2903480 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , PI3K/AkT inhibition , *inhibition* , mTORC1 inhibition , JAK/STAT inhibition , [TLR] suppression , and ACE inhibition . Negative_regulation TLR7 IL10 20625435 2291782 *inhibits* [TLR] induced B-1P cell activation by blocking the classical NF-kappaB pathway . Negative_regulation TLR7 IL10 20979991 2365431 [Toll-like receptor (TLR)] stimulation *induced* substantial level of production by WT DCs , but significantly low level of IL-10 production by TNF-a ( -/- ) DCs . Negative_regulation TLR7 IL1B 17467812 1737428 Inhibition of [TLR] *induced* production , which partially reversed the upregulation of RANKL induced by TLR ligands . Negative_regulation TLR7 IL1R1 19265172 2045526 We found that IFN-beta1a in vitro treatment of human monocyte derived DCs *induced* the expression of [TLR7] and the members of its downstream signaling pathway , including MyD88 , IL-1R associated kinase 4 , and TNF receptor associated factor 6 , while it inhibited the expression of . Negative_regulation TLR7 IL4 24489947 2908361 Moreover , *suppressed* [TLR7-] and TLR9 induced cDC production of pro-inflammatory cytokines such as TNFa , IL-12p70 and IL-6 by inhibiting IFN dependent and NF?B dependent responses . Negative_regulation TLR7 IL4 24489947 2908367 similarly *suppressed* [TLR] responses in splenic DCs . Negative_regulation TLR7 IL8 20067543 2177778 Here we demonstrate that tumour derived prostaglandin E2 ( PGE ( 2 ) ) and transforming growth factor-beta ( TGF-beta ) increase but synergistically *inhibit* interferon-alpha (IFN-alpha) and tumour necrosis factor (TNF) production of [Toll-like receptor 7 (TLR7)-] and Toll-like receptor 9 (TLR9) stimulated PDC . Negative_regulation TLR7 IRAK2 21606490 2450149 Thus IRAK-2 in mice and humans may function differently , and therefore we analyzed the *role* of in [TLR] responses in primary human cells . Negative_regulation TLR7 IRAK3 18354163 1887147 To characterize the inhibition , we assessed the expression of the [TLR] signaling pathway *inhibitor* , ( IRAK-M ) . Negative_regulation TLR7 IRAK3 20042589 2200523 We investigated the role of ( IRAK-M ) , an *inhibitor* of MyD88 dependent [TLR] signaling , in modulating the innate inflammatory response during influenza pneumonia using a murine model . Negative_regulation TLR7 IRAK3 21875872 2501130 TLR7 antagonism almost completely abrogated this phenotype consistent with *mediated* suppression of [TLR7] signalling in vitro . Negative_regulation TLR7 JAK1 24251781 2903481 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , PI3K/AkT inhibition , IKK/JNK inhibition , mTORC1 inhibition , *inhibition* , [TLR] suppression , and ACE inhibition . Negative_regulation TLR7 JAK2 24251781 2903482 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , PI3K/AkT inhibition , IKK/JNK inhibition , mTORC1 inhibition , *inhibition* , [TLR] suppression , and ACE inhibition . Negative_regulation TLR7 JAK3 24251781 2903483 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , PI3K/AkT inhibition , IKK/JNK inhibition , mTORC1 inhibition , *inhibition* , [TLR] suppression , and ACE inhibition . Negative_regulation TLR7 LGALS1 19796680 2183879 These same [TLR] ligand induced NFkappaB responses are not observed in TLR deficient HEK293 cells , but are re-established in HEK293 cells stably transfected with TLR4/MD2 , and are significantly *inhibited* by alpha-2,3-sialyl specific Maackia amurensis ( MAL-2 ) lectin , alpha-2,3-sialyl specific and neuraminidase inhibitor Tamiflu but not by alpha-2,6-sialyl specific Sambucus nigra lectin ( SNA ) . Negative_regulation TLR7 LILRB4 19380766 2065680 In this study , we report that silencing of expression in DC ( ILT3KD DC ) *increases* [TLR] responsiveness to their specific ligands as reflected in increased synthesis and secretion of proinflammatory cytokines such as IL-1alpha , IL-1beta , and IL-6 and type I IFN . Negative_regulation TLR7 LTA 15879147 1406068 In this study we examined the *role* of from GBS in phagocyte activation and the requirements for [TLR-LTA] interaction . Negative_regulation TLR7 LYN 20385881 2262046 The data suggest that the *mediated* negative regulation of [TLR] signaling proceeds , at least in part , via PI3K . Negative_regulation TLR7 MAP3K7 21335610 2443346 In this study , we sought to determine the *role* of the MAP3K in cytokine and [TLR] mediated signalling . Negative_regulation TLR7 MLST8 24251781 2903472 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , PI3K/AkT inhibition , IKK/JNK inhibition , *inhibition* , JAK/STAT inhibition , [TLR] suppression , and ACE inhibition . Negative_regulation TLR7 MTOR 24251781 2903478 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , PI3K/AkT inhibition , IKK/JNK inhibition , *inhibition* , JAK/STAT inhibition , [TLR] suppression , and ACE inhibition . Negative_regulation TLR7 MUC1 18079492 1868349 Here we demonstrate that other [TLR] signaling ( TLR2 , 3 , 4 , 7 , and 9 ) is also *suppressed* by . Negative_regulation TLR7 MUC1 20375631 2239127 Unlike other members of this glycoprotein family , possesses a unique cytosolic region capable of signal transduction and *attenuating* [toll-like receptor (TLR)] activation . Negative_regulation TLR7 MYD88 22155231 2536514 Structural models consistent with these results suggest how TcpB might *inhibit* [TLR] signaling by targeting via a DD-TIR domain interface . Negative_regulation TLR7 MYD88 23490990 2782073 Given the central *role* of in [TLR/IL-1R] signaling , we set out different strategies to develop drugs that can block its function . Negative_regulation TLR7 MYLIP 19022814 1992256 Both have multiple targets , with *inhibiting* [TLR] signalling and miR-155 regulating Th1 cells and also , interestingly , positively regulating mRNA for TNFalpha . Negative_regulation TLR7 MYLIP 23794009 2909209 We propose a *role* for in [TLR] signalling through a negative feedback mechanism involving the attenuation of NF-?B by down-regulation of IRAK-1 and TRAF-6 . Negative_regulation TLR7 MYLIP 24014244 2856807 Here , we investigated the *role* of in [TLR] pathway regulation in human pDCs . Negative_regulation TLR7 MYLIP 24014244 2856837 Furthermore , ectopic expression effectively *impaired* [TLR] mediated signaling in pDCs as TLR induced nuclear factor-?B activation was reduced . Negative_regulation TLR7 NFKB1 17296788 1698864 We found that oxidized low-density lipoprotein ( oxLDL ) was the key active component responsible for this effect , as it could directly uncouple [TLR] mediated signaling on CD8alpha ( - ) myeloid DCs and *inhibit* nuclear translocation . Negative_regulation TLR7 PIK3CA 24251781 2903484 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , *inhibition* , IKK/JNK inhibition , mTORC1 inhibition , JAK/STAT inhibition , [TLR] suppression , and ACE inhibition . Negative_regulation TLR7 PIK3R1 24251781 2903485 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , *inhibition* , IKK/JNK inhibition , mTORC1 inhibition , JAK/STAT inhibition , [TLR] suppression , and ACE inhibition . Negative_regulation TLR7 PTPN22 23871208 2821355 promoted host antiviral responses and was *critical* for [TLR] agonist induced , type 1 IFN dependent suppression of inflammation in colitis and arthritis . Negative_regulation TLR7 PVR 24613691 2933921 Larger randomized trials are needed to determine if can improve ABI and *reduce* [TLR] rates . Negative_regulation TLR7 RELA 17296788 1698865 We found that oxidized low-density lipoprotein ( oxLDL ) was the key active component responsible for this effect , as it could directly uncouple [TLR] mediated signaling on CD8alpha ( - ) myeloid DCs and *inhibit* nuclear translocation . Negative_regulation TLR7 RNF216 15107846 1240713 Conversely , a reduction in endogenous by small interfering RNA increased TLR expression and *enhanced* [TLR] activation . Negative_regulation TLR7 RPTOR 24251781 2903474 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , PI3K/AkT inhibition , IKK/JNK inhibition , *inhibition* , JAK/STAT inhibition , [TLR] suppression , and ACE inhibition . Negative_regulation TLR7 SIGIRR 17495864 1766700 The lack of does not *enhance* [TLR/IL-1R] signaling in tubular epithelial cells as was observed in monocytes . Negative_regulation TLR7 SIGIRR 17495864 1766711 does not *suppress* [TLR] signaling in tubular epithelial cells , which supports their role as sensors of microbial infection in the kidney . Negative_regulation TLR7 SIGIRR 20112371 2219491 Hence , we hypothesized that , an endogenous [TLR] *inhibitor* , prevents oil induced SLE . Negative_regulation TLR7 SIGIRR 20130217 2213349 In this study , we investigated the *role* of in regulating epithelial-specific [TLR] responses and characterized its expression in colonic biopsy specimens . Negative_regulation TLR7 SOAT1 24251781 2903470 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials , AMPK activation , PI3K/AkT inhibition , IKK/JNK inhibition , mTORC1 inhibition , *inhibition* , [TLR] suppression , and ACE inhibition . Negative_regulation TLR7 SOCS2 22291912 2545514 Recent studies suggest that is *involved* in the regulation of [TLR] signaling . Negative_regulation TLR7 SPDEF 23012424 2684416 Here , we demonstrate that was induced by rhinoviral infection of primary human airway cells and that cytoplasmic activities of SPDEF , a transcriptional regulator of airway goblet cell metaplasia , *inhibited* [Toll-like receptor (TLR)] activation of epithelial cells . Negative_regulation TLR7 SPDEF 23012424 2684436 *mediated* inhibition of both [TLR] and type I interferon signaling likely protects the lung against inflammatory damage when inciting stimuli are not eradicated . Negative_regulation TLR7 SRC 20639876 2292302 CD11b was activated by TLR triggered phosphatidylinositol 3-OH kinase ( PI(3)K ) and the effector RapL and fed back to *inhibit* [TLR] signaling by activating the tyrosine kinases and Syk . Negative_regulation TLR7 SRC 21911421 2487201 CHIP mediated enhancement of [TLR] signaling is *inhibited* by IFNAR deficiency or expression of ubiquitination resistant mutant forms of or PKC? . Negative_regulation TLR7 STAT3 20064484 2212121 G-CSF mediated phosphorylation and *inhibition* of [TLR] agonist induced cytokine production were prevented by pretreatment of cells with AG-490 ( JAK2 inhibitor ) . Negative_regulation TLR7 SYK 20138367 2227205 Herein , we investigated the *role* of in [TLR] mediated signaling and gene regulation . Negative_regulation TLR7 TANK 19668221 2126082 Our results demonstrate that constitutive [TLR] signaling by intestinal commensal microflora is *suppressed* by . Negative_regulation TLR7 TGFB1 20067543 2177775 Here we demonstrate that tumour derived prostaglandin E2 ( PGE ( 2 ) ) and ( TGF-beta ) increase interleukin-8 (IL-8) but synergistically *inhibit* interferon-alpha (IFN-alpha) and tumour necrosis factor (TNF) production of [Toll-like receptor 7 (TLR7)-] and Toll-like receptor 9 (TLR9) stimulated PDC . Negative_regulation TLR7 TGFB1 20171181 2228743 Smad7 and Smad6 bind to discrete regions of Pellino-1 via their MH2 domains to mediate *induced* negative regulation of [IL-1R/TLR] signaling . Negative_regulation TLR7 TGFB2 20067543 2177776 Here we demonstrate that tumour derived prostaglandin E2 ( PGE ( 2 ) ) and ( TGF-beta ) increase interleukin-8 (IL-8) but synergistically *inhibit* interferon-alpha (IFN-alpha) and tumour necrosis factor (TNF) production of [Toll-like receptor 7 (TLR7)-] and Toll-like receptor 9 (TLR9) stimulated PDC . Negative_regulation TLR7 TGFB3 20067543 2177777 Here we demonstrate that tumour derived prostaglandin E2 ( PGE ( 2 ) ) and ( TGF-beta ) increase interleukin-8 (IL-8) but synergistically *inhibit* interferon-alpha (IFN-alpha) and tumour necrosis factor (TNF) production of [Toll-like receptor 7 (TLR7)-] and Toll-like receptor 9 (TLR9) stimulated PDC . Negative_regulation TLR7 TLR2 22231652 2636570 Most [toll-like receptor (TLR)] ligands *induced* comparable upregulation of co-stimulatory molecules CD40 , CD86 and B7H1 on young and aged cDC , whereas and TLR5 stimulation resulted in reduced upregulation of CD80 and CD86 on aged cDC in vitro . Negative_regulation TLR7 TLR2 22253793 2538386 Moreover , stimulation of the Muller glia with , 3 , 4 , 5 , 7 and 9 agonists *resulted* in an increased [TLR] expression as assayed by Western blot and flow cytometry . Negative_regulation TLR7 TLR3 16423052 1515292 Coincident with the second phase of NF-kappaB activation in HSV-1 infected HCECs , the expression of [Toll-like receptor 7 (TLR7)] was *induced* , whereas the level of was greatly down-regulated . Negative_regulation TLR7 TLR5 22231652 2636571 Most [toll-like receptor (TLR)] ligands *induced* comparable upregulation of co-stimulatory molecules CD40 , CD86 and B7H1 on young and aged cDC , whereas TLR2 and stimulation resulted in reduced upregulation of CD80 and CD86 on aged cDC in vitro . Negative_regulation TLR7 TLR8 17040905 1649259 The murine that does not respond to any known human TLR8 agonists also *inhibits* both murine and human [TLR7] . Negative_regulation TLR7 TLR8 20811154 2330683 These data provide evidence for a pivotal *role* for mouse in the regulation of mouse [TLR7] expression and prevention of spontaneous autoimmunity . Negative_regulation TLR7 TLR9 17040905 1649258 The results indicate that TLR8 inhibits TLR7 and TLR9 , and *inhibits* [TLR7] but not vice versa in HEK293 cells transfected with TLRs in a pairwise combination . Negative_regulation TLR7 TLR9 24342772 2905382 We identified two compounds , AT791 { 3- [ 4- ( 6- ( 3- ( dimethylamino ) propoxy ) benzo [ d ] oxazol-2-yl ) phenoxy ] -N , N-dimethylpropan-1-amine } and E6446 { 6- [ 3- ( pyrrolidin-1-yl ) propoxy ) -2- ( 4- ( 3- ( pyrrolidin-1-yl ) propoxy ) phenyl ] benzo [ d ] oxazole } , that inhibit [Toll-like receptor (TLR)7] and 9 signaling in a variety of human and mouse cell types and *inhibit* interaction in vitro . Negative_regulation TLR7 TP53 23150340 2717943 Activation of by common antitumor agents *results* in p53 dependent regulation of expression of most [TLR] genes in human primary and cancer cell lines , resulting in modulation of TLR downstream responses to cognate ligands . Negative_regulation TLR7 UTP15 16030017 1453545 In radioimmune assays , we found that ATP ( or ATPgammaS ) strongly increased cAMP levels , and , moreover , the TLR-response was inhibited by forskolin , whereas neither increased cAMP nor *inhibited* the [TLR-response] . Negative_regulation TLR7 UTP18 16030017 1453543 In radioimmune assays , we found that ATP ( or ATPgammaS ) strongly increased cAMP levels , and , moreover , the TLR-response was inhibited by forskolin , whereas neither increased cAMP nor *inhibited* the [TLR-response] . Negative_regulation TLR7 UTP20 16030017 1453541 In radioimmune assays , we found that ATP ( or ATPgammaS ) strongly increased cAMP levels , and , moreover , the TLR-response was inhibited by forskolin , whereas neither increased cAMP nor *inhibited* the [TLR-response] . Negative_regulation TLR7 UTP23 16030017 1453546 In radioimmune assays , we found that ATP ( or ATPgammaS ) strongly increased cAMP levels , and , moreover , the TLR-response was inhibited by forskolin , whereas neither increased cAMP nor *inhibited* the [TLR-response] . Negative_regulation TLR7 UTP3 16030017 1453544 In radioimmune assays , we found that ATP ( or ATPgammaS ) strongly increased cAMP levels , and , moreover , the TLR-response was inhibited by forskolin , whereas neither increased cAMP nor *inhibited* the [TLR-response] . Negative_regulation TLR7 UTP6 16030017 1453542 In radioimmune assays , we found that ATP ( or ATPgammaS ) strongly increased cAMP levels , and , moreover , the TLR-response was inhibited by forskolin , whereas neither increased cAMP nor *inhibited* the [TLR-response] . Negative_regulation TLR8 EPHB2 20802527 2375230 Together , these findings suggest that the new cancer associated ligand , PAUF , may activate TLR mediated signaling to produce the protumorigenic cytokines , but *inhibits* [TLR] mediated NF-?B signaling , thereby facilitating tumor growth and escape from innate immune surveillance . Negative_regulation TLR8 IL1B 17467812 1737429 Inhibition of [TLR] *induced* production , which partially reversed the upregulation of RANKL induced by TLR ligands . Negative_regulation TLR9 CD14 15627643 1349323 On the other hand , [TLR9] expression was decreased by SiO ( 2 ) nano-particles , and expression of the co-receptor was *inhibited* by Co nanoparticles . Negative_regulation TLR9 EPHB2 20802527 2375231 Together , these findings suggest that the new cancer associated ligand , PAUF , may activate TLR mediated signaling to produce the protumorigenic cytokines , but *inhibits* [TLR] mediated NF-?B signaling , thereby facilitating tumor growth and escape from innate immune surveillance . Negative_regulation TLR9 IL1B 17467812 1737430 Inhibition of [TLR] *induced* production , which partially reversed the upregulation of RANKL induced by TLR ligands . Negative_regulation TLR9 TLR7 24342772 2905383 We identified two compounds , AT791 { 3- [ 4- ( 6- ( 3- ( dimethylamino ) propoxy ) benzo [ d ] oxazol-2-yl ) phenoxy ] -N , N-dimethylpropan-1-amine } and E6446 { 6- [ 3- ( pyrrolidin-1-yl ) propoxy ) -2- ( 4- ( 3- ( pyrrolidin-1-yl ) propoxy ) phenyl ] benzo [ d ] oxazole } , that inhibit and 9 signaling in a variety of human and mouse cell types and *inhibit* [DNA-TLR9] interaction in vitro . Negative_regulation TLR9 TNF 18036648 1867003 [Toll-like receptor 9] suppression in plasmacytoid dendritic cells after IgE dependent activation is *mediated* by autocrine . Negative_regulation TLX1 FHL1 18073142 1861926 Here , we provide an explanation for these findings by demonstrating that the induction of , but not ALDH1A1 , *requires* a high level of [TLX1] expression in NIH 3T3 cells . Negative_regulation TM4SF19 MYLIP 24285464 2893881 Our findings that [TM4SF1] expression was *inhibited* by provide new insights into the oncogenic mechanism of TM4SF1 and suggest that miR-141 represents a novel molecular target for PC therapy . Negative_regulation TMA16 IL1B 15972630 1423994 [TMA] *induced* early expression of IL-10 , a cytokine implicated in the negative regulation of Langerhans cell ( LC ) migration , whereas exposure to DNCB resulted in production of the proinflammatory cytokine . Negative_regulation TMA7 IL1B 15972630 1423995 [TMA] *induced* early expression of IL-10 , a cytokine implicated in the negative regulation of Langerhans cell ( LC ) migration , whereas exposure to DNCB resulted in production of the proinflammatory cytokine . Negative_regulation TMED2 IFI27 16687179 1612191 also *inhibited* [p24] accumulation from H9 and U937 cells chronically infected with WT or PI-resistant HIV-1 . Negative_regulation TMED2 TCN1 7685612 219778 In acutely infected PBL cells , and TCN-P *inhibited* reverse transcriptase and infectious virus production but not [p24] core antigen production . Negative_regulation TMED2 TUB 8010099 258512 The results showed that *inhibited* both [p24] production and cytopathogenesis mediated by HTLV-IIIB , and the median effective concentrations ( EC50 ) were 24.1 and 22.9 micrograms . ml-1 , respectively . Negative_regulation TMED7 CAPN8 18182390 1875879 Both striatal [p27] down-regulation and cell death provoked by 3-NP were *dependent* on activity . Negative_regulation TMED7 CCND1 10397744 627875 We simultaneously studied them for p27 , cyclin D3 , cyclin D2 , cyclin D1 , and cyclin E expression , because it has been stated that high levels of expression of or E *lead* to increased [p27] levels in some cell types . Negative_regulation TMED7 CCND1 19153211 2079240 In vivo , azacitidine ( 0.8 mg/kg i.p. ) reduced tumor proliferation and induced apoptosis in both xenografts upmodulating the expression of p16INKA , Bax , Bak , p21/WAF1 , and [p27/KIP1] , and *inhibiting* the activation of Akt activity and the expression of , Bcl-2 , and Bcl-XL . Negative_regulation TMED7 CCND1 19513541 2092470 Western blotting showed that PI-103 induced down-regulation of and E1 and simultaneously *up-regulated* p21 and [p27] , associated with arrest in the G0-G1 phase of the cell cycle . Negative_regulation TMED7 CCND1 20837141 2363750 We found that the binding of and pSer10-p27 ( Kip1 ) *prevents* [p27] ( Kip1 ) degradation by the cytoplasmic Kip1 ubiquitylation promoting complex ( KPC ) proteosomic pathway . Negative_regulation TMED7 CCND1 21209944 2359472 In xenografted tumors , resveratrol upregulated the expressions of TRAIL-R1/DR4 , TRAIL-R2/DR5 , Bax and [p27] ( /KIP1 ) , and *inhibited* the expression of Bcl-2 and . Negative_regulation TMED7 CCND1 21695715 2494309 In the cell cycle related proteins , SJSZ glycoprotein ( 50 µg/ml ) significantly *enhances* the expression of p53 , p21 , and [p27] , whereas it suppressed the activity of . Negative_regulation TMED7 CCND1 24178620 2896971 Immunoprecipitation analyses and siRNA assays suggested a direct *role* of in the regulation of [p27] ( KIP1 ) levels . Negative_regulation TMED7 CCND1 9407076 470819 Overexpression of dominant negative forms of Ras or RhoA completely blocked PDGF induced [p27] ( KIP1 ) degradation , but only dominant negative Ras *inhibited* protein expression . Negative_regulation TMED7 EPHB2 10693934 671264 moreover , a decrease in the levels of the cyclin dependent kinase inhibitor (CKI) [p27] was observed as a *consequence* of activation . Negative_regulation TMED7 EPHB2 15790513 1386368 Inhibiting activation *reduced* the increased expression of [p27] and Bax , but had no effect on the decreased expression of Bcl-2 , suggesting the involvement of ERK activation in the SN-induced increased expression of p27 and Bax . Negative_regulation TMED7 EPHB2 20824291 2341824 [p27] ( Kip1 ) accumulation *results* from the inhibition of the ubiquitin-proteasome system and/or inhibition of signaling . Negative_regulation TMED7 EPHB2 21840777 2486000 Immunoblot analysis demonstrated that downregulation of both and p-AKT downstream of EGFR and ß1 integrin are *involved* in the [p27] upregulation . Negative_regulation TMED7 FOXO1 17015685 1629785 Consistent with the important *role* of in [p27] kip1 transcription , stimulated Vav1 ( -/- ) T cells failed to down-regulate the expression of p27 kip1 , explaining their G0-G1 arrest . Negative_regulation TMED7 IFI27 11374878 817930 ( Kip1 ) associates with cyclin/cdk complexes and inhibiting cdk activity , and overexpression of [p27] ( Kip1 ) *induces* G1 arrest . Negative_regulation TMED7 IFI27 12529328 1071062 Genetic or chemical inhibition of this pathway *induced* [p27] ( Kip1 ) accumulation , whereas MAP kinase reactivation triggered a down-regulation of ( Kip1 ) that could be partially reversed by calpain inhibitors . Negative_regulation TMED7 IFI27 16020508 1465830 Tregs were blocked from cell cycle progression due to decrease of cyclin E and cyclin A and increase of ( [p27kip] cyclin dependent kinase *inhibitor* ) . Negative_regulation TMED7 IFI27 19556892 2117173 In addition , inhibition of threonine-187 phosphorylation of ( kip1 ) protein for ubiquitinyl-proteasomal mediated degradation was also *involved* in upregulation of [p27] ( kip1 ) . Negative_regulation TMED7 IFI27 20837141 2363751 We found that the binding of cyclin D1 and ( Kip1 ) *prevents* [p27] ( Kip1 ) degradation by the cytoplasmic Kip1 ubiquitylation promoting complex ( KPC ) proteosomic pathway . Negative_regulation TMED7 MAP2K6 15475007 1319141 For example , inhibitors of and phosphatidylinositol-3-kinase *induced* [p27] expression primarily in G1 phase , while inhibitors of AKT activity stimulated these levels primarily in S phase . Negative_regulation TMED7 MAP2K6 15572689 1344382 Consistent with these observations , pharmacological inhibition of or PI3'-kinase *inhibited* the effects of activated RAS on the expression of [p27] ( Kip1 ) in NIH 3T3 fibroblasts and in a panel of bona fide human pancreatic cancer cell lines . Negative_regulation TMED7 MAP2K6 20824291 2341830 [p27] ( Kip1 ) accumulation *results* from the inhibition of the ubiquitin-proteasome system and/or inhibition of signaling . Negative_regulation TMED7 TNF 22268651 2559827 induced the expression of CDK2/CDK4 , and *reduced* the expression of p21 ( waf1/cip1 ) [/p27] ( kip1 ) . Negative_regulation TMED7 UCA1 24457952 2907484 Moreover , although hnRNP I enhances the translation of p27 ( Kip1 ) through interaction with the 5'-untranslated region ( 5'-UTR ) of p27 mRNAs , the interaction of with hnRNP I *suppresses* the [p27] protein level by competitive inhibition . Negative_regulation TMEM100 APOE 23246654 2737006 In addition , *reduced* the expression of dendritic cell-specific [transmembrane protein] ( DC-STAMP ) and ATPase , H ( + ) transporting , lysosomal 38kDa , V0 subunit d2 ( ATP6v0d2 ) , genes involved in cell-cell fusion during osteoclastogenesis . Negative_regulation TMEM100 EGFR 19074872 2002742 Our study shows that in human carcinoma ( A431 ) and glioma ( U373 ) cells , the oncogenic forms of ( EGFR ; including EGFRvIII ) *trigger* the up-regulation of tissue factor ( TF ) , the [transmembrane protein] responsible for initiating blood coagulation and signaling through interaction with coagulation factor VIIa . Negative_regulation TMEM100 LPAR1 24429286 2932836 Blocking activity with Ki16425 *inhibited* expression of nuclear factor of activated T-cell cytoplasmic 1 ( NFATc1 ) and dendritic cell-specific [transmembrane protein] and interfered with the fusion but not the proliferation of osteoclast precursors . Negative_regulation TMEM100 RAB13 12058051 952327 Immunofluorescence studies showed that the expression of *delayed* the localization of the TJ [transmembrane protein] , claudin1 , at the cell surface . Negative_regulation TMEM156 APOE 23246654 2737024 In addition , *reduced* the expression of dendritic cell-specific [transmembrane protein] ( DC-STAMP ) and ATPase , H ( + ) transporting , lysosomal 38kDa , V0 subunit d2 ( ATP6v0d2 ) , genes involved in cell-cell fusion during osteoclastogenesis . Negative_regulation TMEM156 EGFR 19074872 2002760 Our study shows that in human carcinoma ( A431 ) and glioma ( U373 ) cells , the oncogenic forms of ( EGFR ; including EGFRvIII ) *trigger* the up-regulation of tissue factor ( TF ) , the [transmembrane protein] responsible for initiating blood coagulation and signaling through interaction with coagulation factor VIIa . Negative_regulation TMEM156 LPAR1 24429286 2932854 Blocking activity with Ki16425 *inhibited* expression of nuclear factor of activated T-cell cytoplasmic 1 ( NFATc1 ) and dendritic cell-specific [transmembrane protein] and interfered with the fusion but not the proliferation of osteoclast precursors . Negative_regulation TMEM156 RAB13 12058051 952345 Immunofluorescence studies showed that the expression of *delayed* the localization of the TJ [transmembrane protein] , claudin1 , at the cell surface . Negative_regulation TMEM211 APOE 23246654 2737104 In addition , *reduced* the expression of dendritic cell-specific [transmembrane protein] ( DC-STAMP ) and ATPase , H ( + ) transporting , lysosomal 38kDa , V0 subunit d2 ( ATP6v0d2 ) , genes involved in cell-cell fusion during osteoclastogenesis . Negative_regulation TMEM211 EGFR 19074872 2002840 Our study shows that in human carcinoma ( A431 ) and glioma ( U373 ) cells , the oncogenic forms of ( EGFR ; including EGFRvIII ) *trigger* the up-regulation of tissue factor ( TF ) , the [transmembrane protein] responsible for initiating blood coagulation and signaling through interaction with coagulation factor VIIa . Negative_regulation TMEM211 LPAR1 24429286 2932934 Blocking activity with Ki16425 *inhibited* expression of nuclear factor of activated T-cell cytoplasmic 1 ( NFATc1 ) and dendritic cell-specific [transmembrane protein] and interfered with the fusion but not the proliferation of osteoclast precursors . Negative_regulation TMEM211 RAB13 12058051 952425 Immunofluorescence studies showed that the expression of *delayed* the localization of the TJ [transmembrane protein] , claudin1 , at the cell surface . Negative_regulation TMEM213 APOE 23246654 2737041 In addition , *reduced* the expression of dendritic cell-specific [transmembrane protein] ( DC-STAMP ) and ATPase , H ( + ) transporting , lysosomal 38kDa , V0 subunit d2 ( ATP6v0d2 ) , genes involved in cell-cell fusion during osteoclastogenesis . Negative_regulation TMEM213 EGFR 19074872 2002777 Our study shows that in human carcinoma ( A431 ) and glioma ( U373 ) cells , the oncogenic forms of ( EGFR ; including EGFRvIII ) *trigger* the up-regulation of tissue factor ( TF ) , the [transmembrane protein] responsible for initiating blood coagulation and signaling through interaction with coagulation factor VIIa . Negative_regulation TMEM213 LPAR1 24429286 2932871 Blocking activity with Ki16425 *inhibited* expression of nuclear factor of activated T-cell cytoplasmic 1 ( NFATc1 ) and dendritic cell-specific [transmembrane protein] and interfered with the fusion but not the proliferation of osteoclast precursors . Negative_regulation TMEM213 RAB13 12058051 952362 Immunofluorescence studies showed that the expression of *delayed* the localization of the TJ [transmembrane protein] , claudin1 , at the cell surface . Negative_regulation TMF1 PLAT 21194375 2396849 Angiostatin , LK68 and Lys-rhLK8 increased clot lysis time in a dose dependent manner , *inhibited* mediated plasminogen activation on a thrombin modified fibrinogen (TMF) surface , showed binding to [TMF] and significantly decreased the amount of plasminogen bound to TMF . Negative_regulation TMOD1 CA2 10096910 601480 *Role* of and cross-bridges in skeletal muscle [thin filament] activation probed with Ca2+ sensitizers . Negative_regulation TMOD1 CA2 19209817 2007305 The smooth muscle-specific actin-bindingprotein caldesmon , together with calmodulin regulates the activity of the [thin filament] in *response* to . Negative_regulation TMOD1 MYO10 15140746 1279555 Isoform switching from SM-B to SM-A *results* in decreased contractility and altered expression of [thin filament] regulatory proteins . Negative_regulation TMOD1 MYO16 15140746 1279554 Isoform switching from SM-B to SM-A *results* in decreased contractility and altered expression of [thin filament] regulatory proteins . Negative_regulation TMOD1 MYO19 15140746 1279553 Isoform switching from SM-B to SM-A *results* in decreased contractility and altered expression of [thin filament] regulatory proteins . Negative_regulation TMOD1 MYO6 15140746 1279556 Isoform switching from SM-B to SM-A *results* in decreased contractility and altered expression of [thin filament] regulatory proteins . Negative_regulation TMOD1 TMOD2 23638401 2779387 Our data demonstrate that [Tmod1] is involved in neuronal differentiation for proper neurite formation and outgrowth , and that *inhibits* these processes . Negative_regulation TMOD1 TPM1 14870966 1182529 The implications of these findings for the *role* of in [thin filament] regulation are discussed . Negative_regulation TMOD1 TPM1 16287977 1484333 Here , we investigate the molecular mechanisms by which *inhibits* myosin 's interactions with the [thin filament] in the absence of calcium by using a laser trap . Negative_regulation TMOD1 TPM1 8509369 221577 The essential *role* of in cooperative regulation of smooth muscle [thin filament] activity by caldesmon . Negative_regulation TMOD1 TPM2 14870966 1182530 The implications of these findings for the *role* of in [thin filament] regulation are discussed . Negative_regulation TMOD1 TPM2 16287977 1484334 Here , we investigate the molecular mechanisms by which *inhibits* myosin 's interactions with the [thin filament] in the absence of calcium by using a laser trap . Negative_regulation TMOD1 TPM2 8509369 221578 The essential *role* of in cooperative regulation of smooth muscle [thin filament] activity by caldesmon . Negative_regulation TMOD1 TPM3 14870966 1182531 The implications of these findings for the *role* of in [thin filament] regulation are discussed . Negative_regulation TMOD1 TPM3 16287977 1484335 Here , we investigate the molecular mechanisms by which *inhibits* myosin 's interactions with the [thin filament] in the absence of calcium by using a laser trap . Negative_regulation TMOD1 TPM3 8509369 221579 The essential *role* of in cooperative regulation of smooth muscle [thin filament] activity by caldesmon . Negative_regulation TMOD1 TPM4 14870966 1182532 The implications of these findings for the *role* of in [thin filament] regulation are discussed . Negative_regulation TMOD1 TPM4 16287977 1484336 Here , we investigate the molecular mechanisms by which *inhibits* myosin 's interactions with the [thin filament] in the absence of calcium by using a laser trap . Negative_regulation TMOD1 TPM4 8509369 221580 The essential *role* of in cooperative regulation of smooth muscle [thin filament] activity by caldesmon . Negative_regulation TMPRSS15 BPI 9845920 553837 The only earlier known in vitro *inhibitor* of [enteropeptidase] , , was localised in vivo in different tissues with this enzyme . Negative_regulation TMPRSS15 FUT4 2427760 61781 Furthermore , *inhibited* the [enterokinase] activity . Negative_regulation TNC TNF 15592496 1375241 Since preinflammatory cytokines also act through p38MAPK and JNK signaling pathways , the possible *role* of in [tenascin-W] expression was also examined . Negative_regulation TNF A2M 2472279 113665 The secretion of [tumor necrosis factor (TNF)] by human peripheral blood mononuclear cells was *suppressed* by either whole human plasma alpha-globulins or purified alpha 1-acid-glycoprotein , alpha 1-antitrypsin and in a concentration dependent manner . Negative_regulation TNF ABCB11 15860642 1464961 [TNF-alpha] *induces* a sustained decrease in Ntcp , Oatp1/Oatp1a1 , and mRNA expression but exerts only transient [ multidrug resistance associated protein 2 ( Mrp2 ) ] or no effects ( Mrp3 ) on Mrps . Negative_regulation TNF ABCC6 7788449 313072 Several and APA *inhibited* monocyte [TNF] production in a concentration dependent manner . Negative_regulation TNF ABCG2 14722201 1197890 Collectively , induction , augmented TNFalpha release , and less efficient *inhibition* of [TNFalpha] production by SSZ may contribute to diminished efficacy after prolonged exposure to SSZ . Negative_regulation TNF ACD 2785495 111503 It was shown that induction of [TNF-alpha] synthesis by LPS was not *blocked* by and Amn . Negative_regulation TNF ACE 12484517 1024886 These data indicate that the local TNF-alpha expression is tissue-specific , and that *upregulation* of [TNF-alpha] in EPI by exercise training and/or inhibition may have contributed to the reduction in fat cell volume via the induction of apoptosis and/or the regulation of metabolic homeostasis . Negative_regulation TNF ACE 17342403 1712281 In addition , pharmacologic both prevents apoptosis and *reduces* [TNF-alpha] expression in vitro . Negative_regulation TNF ACE 8580368 337504 We conclude that certain *suppress* IL-1 and [TNF] synthesis at a posttranscriptional level and might therefore influence cytokine mediated cell growth . Negative_regulation TNF ACP2 23509807 2756987 NaO induced BNBD4 , , and BNBD10 mRNA expression , but BNBD5 and [TNF-a] were *inhibited* . Negative_regulation TNF ACSM3 18393372 1899376 also *inhibited* H3K4 binding to [TNFalpha] and iNOS promoters . Negative_regulation TNF ACSM3 23895491 2825694 *resulted* in increased levels of plasma [tumour necrosis factor (TNF)-a] , interleukin (IL)-1ß , IL-6 levels and caspase-3 activity . Negative_regulation TNF ADAM17 12014967 941736 The best compound inhibits MMPs and with nanomolar potency and *inhibits* the release of [TNFalpha] from cells with an IC50 of 48 nM . Negative_regulation TNF ADAM17 12973924 1139664 It was concluded that all the three types of TACE inhibitors can regulate the expression of at different levels and *inhibit* [sTNF alpha] secretion , indicating TACE is a novel target for inflammation therapy . Negative_regulation TNF ADAM17 15206946 1261304 Therefore , *dependent* depletion of membrane bound [tumor necrosis factor] receptors from endothelial cells might constitute a mechanism of self-protection in states of prolonged immunostimulation . Negative_regulation TNF ADAM17 15556048 1340139 These observations suggest that TACE in PBMC is an important regulator of TNF-alpha maturation , meaning that may be a potential *target* for the inhibition of cellular [TNF-alpha] production in CHF . Negative_regulation TNF ADAM17 15603556 1380744 These results demonstrate that TACE mediated TNF-alpha maturation in PBMCs may play an important role in poor outcomes from AMI , suggesting that may be a potential *target* for the inhibition of cellular [TNF-alpha] production in AMI . Negative_regulation TNF ADAM17 21078557 2349626 Twelve analogues were synthesized and most of compounds were active in vitro enzyme inhibition as well as cellular [TNF-a] *inhibition* . Negative_regulation TNF ADAM17 21722904 2483889 Increased activities of matrix metalloproteinase (MMP)-9 and MMP-2 , numbers of Mac-2 positive macrophages , CD3 positive T lymphocytes and CD31 positive vessels in periaortic tissues , mRNA expression of CD68 , monocyte chemotactic protein-1 , [TNF-a] , vascular endothelial growth factor-A , p47 and glutathione peroxidases , and protein expression of phospho-c-Jun N-terminal kinase in AAA were all *attenuated* by deletion . Negative_regulation TNF ADAM17 22367719 2586990 Induced vascular permeability , oedema formation , release of [TNF-a] and IL-6 and pulmonary leukocyte recruitment were all markedly *reduced* by GW280264X or endothelial . Negative_regulation TNF ADAM19 15292243 1302965 However , overexpression of *increased* the constitutive release of [TNFalpha] , whereas overexpression of ADAM9 or ADAM10 did not . Negative_regulation TNF ADCY1 22700656 2633806 Specifically , activation of trypanosome resulting from parasite phagocytosis by liver myeloid cells *inhibited* the synthesis of the trypanosome controlling cytokine [tumor necrosis factor-a] through activation of protein kinase A in these cells . Negative_regulation TNF ADCY10 22700656 2633805 Specifically , activation of trypanosome resulting from parasite phagocytosis by liver myeloid cells *inhibited* the synthesis of the trypanosome controlling cytokine [tumor necrosis factor-a] through activation of protein kinase A in these cells . Negative_regulation TNF ADCY2 22700656 2633807 Specifically , activation of trypanosome resulting from parasite phagocytosis by liver myeloid cells *inhibited* the synthesis of the trypanosome controlling cytokine [tumor necrosis factor-a] through activation of protein kinase A in these cells . Negative_regulation TNF ADCY3 22700656 2633808 Specifically , activation of trypanosome resulting from parasite phagocytosis by liver myeloid cells *inhibited* the synthesis of the trypanosome controlling cytokine [tumor necrosis factor-a] through activation of protein kinase A in these cells . Negative_regulation TNF ADCY4 22700656 2633809 Specifically , activation of trypanosome resulting from parasite phagocytosis by liver myeloid cells *inhibited* the synthesis of the trypanosome controlling cytokine [tumor necrosis factor-a] through activation of protein kinase A in these cells . Negative_regulation TNF ADCY5 22700656 2633810 Specifically , activation of trypanosome resulting from parasite phagocytosis by liver myeloid cells *inhibited* the synthesis of the trypanosome controlling cytokine [tumor necrosis factor-a] through activation of protein kinase A in these cells . Negative_regulation TNF ADCY6 22700656 2633811 Specifically , activation of trypanosome resulting from parasite phagocytosis by liver myeloid cells *inhibited* the synthesis of the trypanosome controlling cytokine [tumor necrosis factor-a] through activation of protein kinase A in these cells . Negative_regulation TNF ADCY7 22700656 2633812 Specifically , activation of trypanosome resulting from parasite phagocytosis by liver myeloid cells *inhibited* the synthesis of the trypanosome controlling cytokine [tumor necrosis factor-a] through activation of protein kinase A in these cells . Negative_regulation TNF ADCY8 22700656 2633813 Specifically , activation of trypanosome resulting from parasite phagocytosis by liver myeloid cells *inhibited* the synthesis of the trypanosome controlling cytokine [tumor necrosis factor-a] through activation of protein kinase A in these cells . Negative_regulation TNF ADCY9 22700656 2633814 Specifically , activation of trypanosome resulting from parasite phagocytosis by liver myeloid cells *inhibited* the synthesis of the trypanosome controlling cytokine [tumor necrosis factor-a] through activation of protein kinase A in these cells . Negative_regulation TNF ADCYAP1 10496178 647165 We reported previously that VIP and *inhibit* IL-6 , IL-12 , [TNF alpha] and NO production , and enhance IL-10 production , from lipopolysaccharide (LPS) stimulated macrophages . Negative_regulation TNF ADCYAP1 10496178 647169 The *inhibition* of [TNF alpha] and NO occurs through both CD14 dependent and -independent mechanisms , whereas the inhibition of IL-6 production appears to be strictly CD14 dependent . Negative_regulation TNF ADCYAP1 10542221 563763 We showed previously that VIP and *inhibit* the production of macrophage derived [tumor necrosis factor-alpha] , interleukin (IL)-6 , nitric oxide , and IL-12 . Negative_regulation TNF ADCYAP1 10804204 691924 [TNF-alpha] protein levels were *reduced* 90 % by VIP or at 10 ( -7 ) m . Negative_regulation TNF ADCYAP1 10804204 691927 We conclude that VIP and *inhibit* the production of [TNF-alpha] from activated microglia by a cAMP dependent pathway . Negative_regulation TNF ADCYAP1 12525573 1048050 VIP and *inhibit* [TNF-alpha] , IL-1beta , IL-6 , and NO production by lipopolysaccharide (LPS) activated microglia . Negative_regulation TNF ADCYAP1 16891616 1632572 The critical role of NADPH oxidase for GIF and PACAP38 neuroprotection against LPS induced DA neurotoxicity was demonstrated using neuron-glia cultures from mice deficient in NADPH oxidase ( PHOX ( -/- ) ) , where and GIF *reduced* [tumor necrosis factor] alpha production and were neuroprotective only in PHOX ( +/+ ) cultures and not in PHOX ( -/- ) cultures . Negative_regulation TNF ADCYAP1 19647754 2182945 By acting downstream of NF-kappaB to inhibit I kappaB alpha gene induction by TNF-alpha , may *block* I kappaB alpha dependent negative autoregulation of [TNF-alpha] signaling through NF-kappaB , prolonging TNF-alpha dependent signaling to neuropeptide encoding genes in chromaffin cells . Negative_regulation TNF ADCYAP1 20514524 2367823 also *reduced* plasma and kidney levels of [tumor necrosis factor-a] and restored collagen IV levels . Negative_regulation TNF ADCYAP1 24928446 2952227 Here we show that [TNF] is constitutively expressed in PC12 cells in a manner dependent on NF-?B transcription factor , and that rapidly *inhibits* TNF expression and secretion . Negative_regulation TNF ADCYAP1 9813054 546158 Both VIP and *inhibit* [TNFalpha] production from lipopolysaccharide stimulated RAW 246.7 cells in a dose- and time dependent manner . Negative_regulation TNF ADCYAP1 9916753 587543 *reduce* serum and peritoneal [TNF-alpha] and IL-6 , suggesting that the protective effect is exerted by inhibiting the production of endogenous TNF-alpha/IL-6 . Negative_regulation TNF ADCYAP1 9973433 596158 Previous reports showed that *inhibit* IL-6 and [TNF-alpha] production in LPS stimulated macrophages . Negative_regulation TNF ADIPOQ 15033490 1223486 , an adipocyte derived hormone , *attenuates* the production of [TNFalpha] by activated human macrophages . Negative_regulation TNF ADIPOQ 15033490 1223487 *suppressed* both [TNFalpha] and IL6 production in macrophages activated with lipopolysaccharide ( P < 0.01 ) . Negative_regulation TNF ADIPOQ 16039610 1437625 , an adipocyte derived hormone , reportedly *suppresses* the production of [TNF-alpha] and IL-6 by LPS stimulated human or porcine macrophages , and the phagocytosis of microbeads by human macrophages . Negative_regulation TNF ADIPOQ 16155579 1461369 In cultured cardiac cells , *inhibited* apoptosis and [TNF-alpha] production . Negative_regulation TNF ADIPOQ 17327444 1706612 Plasma concentrations of leptin decreased and *increased* significantly by 1 month , and decreases in interleukin-6 , C-reactive protein (CRP) , and [tumor necrosis factor-alpha] were observed at 6 months of weight loss . Negative_regulation TNF ADIPOQ 21226932 2386688 *suppressed* secretion of IL-6 and [TNF-a] in stimulated monocytes and TLR4 was expressed on cell surfaces . Negative_regulation TNF ADIPOQ 24397980 2917466 significantly *reduced* [tumor necrosis factor] ( TNF ) a-induced intercellular adhesion molecule-1 expression and attenuated TNFa induced oxidative/nitrative stress in human umbilical vein endothelial cells . Negative_regulation TNF ADM 10601648 574635 *suppresses* interleukin-1beta induced [tumor necrosis factor-alpha] production in Swiss 3T3 cells . Negative_regulation TNF ADM 10601648 574637 We demonstrated that *inhibited* interleukin-1beta induced [tumor necrosis factor-alpha (TNF-alpha)] secretion and gene transcription in Swiss 3T3 fibroblasts maximally to 23 % and 18 % of control , while the other peptides elevating intracellular cAMP levels elicited much weaker effects . Negative_regulation TNF ADM 19014513 2006629 Analysis of mRNA levels showed that significantly *reduced* [TNFalpha] mRNA expression by 21 % to 49 % in a dose dependent manner , and dose-dependently increased IL-6 mRNA expression by 45 % to 121 % . Negative_regulation TNF ADO 12598934 1062155 ( 2 ) exogenous *inhibits* the production of [TNF-alpha] after H/R injury ; Negative_regulation TNF ADO 8326132 223412 In this study and the synthetic ADO analogue MDL201112 *inhibited* [TNF-alpha] , but not IL-1 , production by activated mouse peritoneal macrophages and the macrophage-like cell lines J774 and RAW-264 . Negative_regulation TNF ADORA1 15748700 1379387 The *role* of and A2B receptors in the regulation of [TNF-alpha] production by human monocytes . Negative_regulation TNF ADORA2A 16280366 1502545 In LPS stimulated human neutrophils , engagement of the selectively *prevented* the expression and release of [TNF-alpha] , MIP-1alpha/CCL3 , MIP-1beta/CCL4 , MIP-2alpha/CXCL2 , and MIP-3alpha/CCL20 . Negative_regulation TNF ADORA2A 17693933 1882344 Stimulation of *inhibits* LPS induced expression of intercellular adhesion molecule 1 and production of [TNF-alpha] in human peripheral blood mononuclear cells . Negative_regulation TNF ADORA3 15748700 1379388 The *role* of and A2B receptors in the regulation of [TNF-alpha] production by human monocytes . Negative_regulation TNF ADORA3 16188954 1500822 Activation of the in RAW 264.7 cells *inhibits* lipopolysaccharide stimulated [tumor necrosis factor-alpha] release by reducing calcium dependent activation of nuclear factor-kappaB and extracellular signal regulated kinase 1/2 . Negative_regulation TNF ADORA3 16324785 1519054 Taken together , these results suggest that activation *suppresses* [TNF-alpha] production by inhibiting PI 3-kinase/Akt and NF-kappaB activation in LPS treated BV2 microglial cells . Negative_regulation TNF ADORA3 8884219 391007 Thus , the binding of adenosine receptor agonists to the interrupts the endotoxin CD14 receptor signal transduction pathway and *blocks* induction of cytokine [TNF-alpha] , revealing a novel cross-talk between the murine adenosine A3 receptor and the endotoxin CD14 receptor in J774.1 macrophages . Negative_regulation TNF ADORA3 9193789 438044 Thus , the binding of adenosine receptor agonists to the interrupts the endotoxin CD14 receptor signal transduction pathway and *blocks* induction of cytokine [TNF-alpha] , revealing a novel cross-talk between the murine adenosine A3 receptor and the endotoxin CD14 receptor in J774.1 macrophages . Negative_regulation TNF ADRB2 10857765 704527 These findings indicate that stimulation during an LPS challenge *prevented* [TNF-alpha] production as a consequence of MAPK inhibition and enhanced cAMP generation , which at a later stage was associated with an anti-inflammatory effect of IL-6 . Negative_regulation TNF ADRB2 11675405 873341 In summary , the downregulation of [TNF-alpha] transcription by terbutaline was *mediated* by an inhibitory effect of activation on MAPK ( p42/p44 , p38 ) and NF-kappa B ( p50/p65 ) , which were exerted through a cAMP-PKA pathway and a cAMP independent mechanism . Negative_regulation TNF ADRB2 16790355 1585795 blockade partially *restores* ex vivo [TNF] production following hemorrhagic shock . Negative_regulation TNF AGA 23685153 2805882 To determine the role of ADA2 , we found that induces ADA2 expression , ADA2 activity and TNF-a release , and that [TNF-a] release is *blocked* by ADA2 neutralizing antibody or ADA2 siRNA , but not by scrambled siRNA . Negative_regulation TNF AGTR1 16047559 1438365 FS .0-2.0 mg/ml and 0.125-2.0 mg/ml significantly *inhibited* NO production and [TNF-alpha] , respectively . Negative_regulation TNF AGTR2 19399939 2070317 After treatment with 5-FU , [TNF-alpha] , IL-1 , and IL-6 in serum of rats of Group C were *inhibited* and 6 h after operation ( P < 0.05 ) , and IL-10 , TGF-beta were inhibited at 24 h compared to Group B ( P < 0.05 ) . Negative_regulation TNF AGTR2 21288138 2431242 Further , activation *reduced* [TNF-a] production by 39 % and STAT3 phosphorylation by 83 % . Negative_regulation TNF AGTR2 23300732 2712412 However , did not *suppress* [TNF/Act-D] and menadione induced apoptosis . Negative_regulation TNF AGXT 15120611 1242025 In addition , an adenosine receptor antagonist <8-SPT> *had* no effect on AICAR induced suppression of [TNF-alpha] levels . Negative_regulation TNF AGXT 23907072 2835762 and BioA suppressed the antigen induced phosphorylation of the downstream signaling intermediates , including MAPK and Akt , which are critical for the production of pro-inflammatory cytokines , and also significantly *attenuated* the production of IgE mediated pro-inflammatory cytokines , such as IL-4 , IL-13 , and [TNF-a] . Negative_regulation TNF AHR 21830830 2495626 Also , *diminished* the serum [tumor necrosis factor] ( TNF-a ) at 5 h after Carr injection . Negative_regulation TNF AKAP13 19277197 2046279 Incubation of LPS treated DC with *results* in 80 % inhibition of [TNF-alpha] and IL-10 production . Negative_regulation TNF AKAP17A 14604983 1187728 Synergistic B cell activation by CD40 and the B cell antigen receptor : role of receptor *mediated* kinase activation and [tumor necrosis factor] receptor associated factor regulation . Negative_regulation TNF AKAP8 19531803 2098813 Suppression of LPS induced [TNF-alpha] production in macrophages by cAMP is *mediated* by . Negative_regulation TNF AKT1 10655266 663493 The *role* of and mitogen activated protein kinase in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Negative_regulation TNF AKT1 10984605 732203 The present study investigates the *role* of in the activation of NF-kappa B by [tumor necrosis factor-alpha] ( TNF alpha , 10 ng/ml ) and PDGF-BB ( 20 ng/ml ) in human vascular smooth muscle cells (SMC) , skin and foreskin fibroblasts . Negative_regulation TNF AKT1 11429162 831576 Suppression of signaling markedly *enhanced* the apoptotic activity of both [TNF] and TRAIL in LNCaP cells but not in PC-3 cells . Negative_regulation TNF AKT1 12145106 969690 To determine the *role* of in [TNF-alpha] release , cells were transiently transfected with a dominant negative form of Akt ( K179M ) . Negative_regulation TNF AKT1 18701653 1974120 TNF increases AKT phosphorylation ( +50 % ) and stimulation of with IGF does not *prevent* [TNF] induction of atrogin mRNA . Negative_regulation TNF AKT1 19118509 2004776 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and [TNF-alpha] and *inhibited* the phosphorylation of , PKCdelta and p38 mitogen activated protein kinase (MAPK) . Negative_regulation TNF AKT1 19801900 2148200 Vaspin did not inhibit the [TNF-alpha] ( 20 min ) activation of JNK , p38 and NF-kappaB , but only slightly *inhibited* . Negative_regulation TNF AKT1 20632386 2316660 Our results showed that GDNF resulted in a significant reduction in enhanced permeability , *inhibited* MPO activity , IL-1beta and [TNF-alpha] expression , and increased ZO-1 and expression . Negative_regulation TNF AKT1 21282635 2393014 Both FFAs and [TNF] *induce* an inhibitor , carboxyl-terminal modulator protein ( CTMP ) . Negative_regulation TNF AKT1 21949832 2488050 Present study investigates the *role* of and Jak/Stat pathway in the IL-10 modulation of [TNF-a] induced cardiomyocyte apoptosis . Negative_regulation TNF AKT1 22203480 2568867 Blocking Erk or by pharmacological agent *reduced* [TNF-a] or NO production in MMD overexpressing macrophages , respectively . Negative_regulation TNF AKT1 22298084 2546352 Moreover in the infarcted heart of HET mice , inhibition decreased Stat3 phosphorylation and IL-10 expression , and blockade of the IL-10 receptor *increased* [TNF-a] and MMP-2 expression . Negative_regulation TNF AKT1 22305016 2565175 [TNF-a] could not *induce* both expression of lipogenic proteins and lipid synthesis when expression was attenuated with siRNA . Negative_regulation TNF AKT2 10984605 732204 The present study investigates the *role* of in the activation of NF-kappa B by [tumor necrosis factor-alpha] ( TNF alpha , 10 ng/ml ) and PDGF-BB ( 20 ng/ml ) in human vascular smooth muscle cells (SMC) , skin and foreskin fibroblasts . Negative_regulation TNF AKT2 11429162 831577 Suppression of signaling markedly *enhanced* the apoptotic activity of both [TNF] and TRAIL in LNCaP cells but not in PC-3 cells . Negative_regulation TNF AKT2 12145106 969691 To determine the *role* of in [TNF-alpha] release , cells were transiently transfected with a dominant negative form of Akt ( K179M ) . Negative_regulation TNF AKT2 18701653 1974121 TNF increases AKT phosphorylation ( +50 % ) and stimulation of with IGF does not *prevent* [TNF] induction of atrogin mRNA . Negative_regulation TNF AKT2 19118509 2004777 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and [TNF-alpha] and *inhibited* the phosphorylation of , PKCdelta and p38 mitogen activated protein kinase (MAPK) . Negative_regulation TNF AKT2 19801900 2148201 Vaspin did not inhibit the [TNF-alpha] ( 20 min ) activation of JNK , p38 and NF-kappaB , but only slightly *inhibited* . Negative_regulation TNF AKT2 20632386 2316661 Our results showed that GDNF resulted in a significant reduction in enhanced permeability , *inhibited* MPO activity , IL-1beta and [TNF-alpha] expression , and increased ZO-1 and expression . Negative_regulation TNF AKT2 21282635 2393015 Both FFAs and [TNF] *induce* an inhibitor , carboxyl-terminal modulator protein ( CTMP ) . Negative_regulation TNF AKT2 21949832 2488051 Present study investigates the *role* of and Jak/Stat pathway in the IL-10 modulation of [TNF-a] induced cardiomyocyte apoptosis . Negative_regulation TNF AKT2 22203480 2568868 Blocking Erk or by pharmacological agent *reduced* [TNF-a] or NO production in MMD overexpressing macrophages , respectively . Negative_regulation TNF AKT2 22298084 2546353 Moreover in the infarcted heart of HET mice , inhibition decreased Stat3 phosphorylation and IL-10 expression , and blockade of the IL-10 receptor *increased* [TNF-a] and MMP-2 expression . Negative_regulation TNF AKT2 22305016 2565176 [TNF-a] could not *induce* both expression of lipogenic proteins and lipid synthesis when expression was attenuated with siRNA . Negative_regulation TNF AKT3 10984605 732205 The present study investigates the *role* of in the activation of NF-kappa B by [tumor necrosis factor-alpha] ( TNF alpha , 10 ng/ml ) and PDGF-BB ( 20 ng/ml ) in human vascular smooth muscle cells (SMC) , skin and foreskin fibroblasts . Negative_regulation TNF AKT3 11429162 831578 Suppression of signaling markedly *enhanced* the apoptotic activity of both [TNF] and TRAIL in LNCaP cells but not in PC-3 cells . Negative_regulation TNF AKT3 12145106 969692 To determine the *role* of in [TNF-alpha] release , cells were transiently transfected with a dominant negative form of Akt ( K179M ) . Negative_regulation TNF AKT3 18701653 1974122 TNF increases AKT phosphorylation ( +50 % ) and stimulation of with IGF does not *prevent* [TNF] induction of atrogin mRNA . Negative_regulation TNF AKT3 19118509 2004778 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and [TNF-alpha] and *inhibited* the phosphorylation of , PKCdelta and p38 mitogen activated protein kinase (MAPK) . Negative_regulation TNF AKT3 19801900 2148202 Vaspin did not inhibit the [TNF-alpha] ( 20 min ) activation of JNK , p38 and NF-kappaB , but only slightly *inhibited* . Negative_regulation TNF AKT3 20632386 2316662 Our results showed that GDNF resulted in a significant reduction in enhanced permeability , *inhibited* MPO activity , IL-1beta and [TNF-alpha] expression , and increased ZO-1 and expression . Negative_regulation TNF AKT3 21282635 2393016 Both FFAs and [TNF] *induce* an inhibitor , carboxyl-terminal modulator protein ( CTMP ) . Negative_regulation TNF AKT3 21949832 2488052 Present study investigates the *role* of and Jak/Stat pathway in the IL-10 modulation of [TNF-a] induced cardiomyocyte apoptosis . Negative_regulation TNF AKT3 22203480 2568869 Blocking Erk or by pharmacological agent *reduced* [TNF-a] or NO production in MMD overexpressing macrophages , respectively . Negative_regulation TNF AKT3 22298084 2546354 Moreover in the infarcted heart of HET mice , inhibition decreased Stat3 phosphorylation and IL-10 expression , and blockade of the IL-10 receptor *increased* [TNF-a] and MMP-2 expression . Negative_regulation TNF AKT3 22305016 2565177 [TNF-a] could not *induce* both expression of lipogenic proteins and lipid synthesis when expression was attenuated with siRNA . Negative_regulation TNF AKTIP 20706780 2474755 Next , we have shown that preferentially *inhibited* prostaglandin (PG) D(2) and [tumor necrosis factor (TNF)-a] release without having any significant effect on MC ß-hexosaminidase secretion . Negative_regulation TNF ALAS2 19379723 2081943 In addition , *suppressed* the production of [TNF-alpha] by human keratinocytes stimulated in vitro with TPA and calcium ionophore . Negative_regulation TNF ALAS2 19379723 2081946 As immunostaining analysis revealed that PDE7A is expressed in the epidermis and TNF-alpha is known to contribute to the TPA induced edema , it is possible that the inhibitory effect of on skin edema in mouse TPA induced dermatitis model is *mediated* by suppression of [TNF-alpha] production . Negative_regulation TNF ALG1 16640552 1552967 In injured brain , + II *inhibit* macrophages , T lymphocytes and their formation of interleukins , [tumor necrosis factor-alpha] , matrix metalloproteinases , and reactive oxygen species . Negative_regulation TNF ALK 21985290 2507598 Furthermore , markedly induced c-jun and HO-1 protein expression and *suppressed* serum aminotransferase activities , [TNF-a] expression , and hepatocyte damage in liver tissues of LPS/d-GalN treated mice . Negative_regulation TNF ALOX5 1650523 163017 The selective <5-lipoxygenase> inhibitors , ICI207968 , A64077 and BWA4C , and the 5-lipoxygenase translocation inhibitor MK886 , decreased leukotriene generation but *enhanced* [TNF] production . Negative_regulation TNF ALOX5AP 10724259 677477 These results demonstrate that S. aureus does not further elevate TNFalpha levels in the presence of an open fracture and that a muscle *reduces* pro-inflammatory [TNFalpha] levels during early wound healing . Negative_regulation TNF AMBP 12667621 1075606 The aim of this study therefore was to determine whether directly *reduces* lipopolysaccharide (LPS) induced secretion of [TNF-alpha] from murine macrophage-like cell line RAW 264.7 cells and Kupffer cells isolated from normal rats . Negative_regulation TNF AMBP 12667621 1075607 Although incubation with AM or AMBP-1 alone inhibited LPS induced TNF-alpha release by 14-22 % and 13-22 % , respectively , AM and in combination significantly *suppressed* [TNF-alpha] production ( by 24-35 % ) . Negative_regulation TNF AMBP 12667621 1075608 In the Kupffer cells primary culture , AM or alone *inhibited* LPS induced [TNF-alpha] production by 52 % and 44 % , respectively . Negative_regulation TNF AMBP 12667621 1075609 These results indicate that AM and in combination effectively *suppress* LPS induced [TNF-alpha] expression and release especially from primary cultured Kupffer cells , suggesting that the downregulatory effect of AM/AMBP-1 on proinflammatory cytokine TNF-alpha may represent a mechanism responsible for their beneficial effects in preventing inflammatory responses and tissue damage in sepsis . Negative_regulation TNF AMBP 18496585 1933723 Human AM and human in combination significantly *inhibited* lipopolysaccharide induced [tumor necrosis factor (TNF)-alpha] and interleukin (IL)-6 production from macrophages . Negative_regulation TNF AMN 2785495 111502 It was shown that induction of [TNF-alpha] synthesis by LPS was not *blocked* by AcD and . Negative_regulation TNF ANGPT2 22859861 2682414 Serum [TNF-a] levels were *reduced* by , whereas those of interleukin (IL)-6 and IL-10 remained unchanged . Negative_regulation TNF ANXA1 22164217 2517885 Our results clearly indicate that propofol can up-regulate to *inhibit* the phosphorylation level of p38 and release of IL-1ß , IL-6 and [TNF-a] , so as to inhibit inflammatory response . Negative_regulation TNF ANXA1 23267026 2732560 Similarly , experiments using AnxA1 ( -/- ) OT-II CD4 ( + ) T cells demonstrated that the absence of in T cells was sufficient to induce increased Ag-specific CD4 ( + ) T cell proliferation in vivo , *augment* T cell production of IFN-? , IL-17 , [TNF] , and IL-6 , and increase Akt , ERK , and p38 activation . Negative_regulation TNF APC 10768983 685076 *inhibited* the secretion of [tumor necrosis factor alpha (TNF-alpha)] induced by H. pylori LPS . Negative_regulation TNF APC 10930989 720131 *inhibited* LPS induced production of [TNF-alpha] both in the presence and absence of fetal calf serum ( FCS ) , although the effect was less marked with 10 % FCS . Negative_regulation TNF APC 11022125 737971 We report that *inhibits* in vitro the release of [tumor necrosis factor (TNF)] and macrophage migration inhibitory factor ( MIF ) , two known cytokine mediators of bacterial septic shock , from lipopolysaccharide (LPS) stimulated human monocytes . Negative_regulation TNF APC 11535575 854729 Because , a physiological anticoagulant , *inhibits* [TNF-alpha] production , it might prevent hypotension by inhibiting excessive production of NO . Negative_regulation TNF APC 11535575 854731 significantly *inhibited* the increases in lung tissue levels of [TNF-alpha] and expression of TNF-alpha mRNA in animals given ET . Negative_regulation TNF APC 11918684 894991 directly *inhibits* the production of [TNF-alpha] by inhibiting the activation of both nudear factor kappaB (NFkappaB) and activator protein-1 in monocytes stimulated with LPS . Negative_regulation TNF APC 12195699 981735 , an important natural anticoagulant , *inhibits* [tumor necrosis factor-alpha (TNF-alpha)] production and attenuates various deleterious events induced by lipopolysaccharide (LPS) , contributing thereby to a significant reduction of mortality in patients with severe sepsis . Negative_regulation TNF APC 12195699 981736 In this study , we investigated the mechanism ( s ) by which *inhibits* [TNF-alpha] production by LPS stimulated human monocytes in vitro . Negative_regulation TNF APC 12195699 981737 Although *inhibited* LPS induced [TNF-alpha] production in a concentration dependent fashion , diisopropyl fluorophosphate treated APC , an active-site blocked APC , had no effect . Negative_regulation TNF APC 12195699 981744 These observations strongly suggest that *inhibited* LPS induced [TNF-alpha] production by inhibiting the activation of both NF-kappa B and AP-1 and that the inhibitory activity of APC might depend on its serine protease activity . Negative_regulation TNF APC 14995995 1216209 Furthermore , *inhibited* WIRS induced increases in plasma levels of [TNF-alpha] . Negative_regulation TNF APC 15061350 1230537 *inhibited* ET-induced [TNF-alpha] production in human monocytes by inhibiting activation of nuclear factor K-B and activator protein-1 in vitro . Negative_regulation TNF APC 15320513 1286516 *inhibits* ET-induced [TNF-alpha] production in vitro in human monocytes by inhibiting activation of NFkappaB and AP-1 by inhibiting degradation of IkappaB and mitogen activated protein kinase pathways , respectively . Negative_regulation TNF APC 16497622 1528851 significantly *inhibited* in vitro the expression of [TNFalpha] and MCP-1 from LI90 stellate cells . Negative_regulation TNF APC 17644074 1780301 *attenuated* the LPS induced protein expression of inflammatory cytokines , [tumor necrosis factor-alpha] , and interleukin-6 , as evaluated by ELISA in neonatal rat brains . Negative_regulation TNF APC 17763449 1801848 Furthermore , directly *suppressed* the production of [tumor necrosis factor (TNF)] and the activation of NF-kappaB and MAP kinase p38 , and inhibitors of NF-kappaB or p38 reduced the production of MMP-9 , suggesting that APC inhibits MMP-9 by blocking TNF , NF-kappaB , and p38 . Negative_regulation TNF APC 7523500 272210 Thus , *inhibited* the production of [TNF-alpha] and prevented down-regulation of membrane CD11b , CD14 , and CD18 , but had no effect on up-regulation of MHC class II , ICAM-1 , or IL-2R , down-regulation of MO expression of another glycophosphatidylinositol linked protein , CD59 , or production of reactive oxygen intermediates . Negative_regulation TNF APC 9053444 417221 A splenic *reduced* IFN-gamma and [TNF-alpha] production by established Th1 MBP-specific Ak-restricted B10 .BR TCL and by a Th1 KLH-specific , Ek-restricted B10 .BR T cell clone . Negative_regulation TNF APC 9124369 419521 APC , but not DEGR-Xa or , significantly *inhibited* the LPS induced increase in the plasma level of [TNF] . Negative_regulation TNF APC 9124369 419522 significantly *inhibited* the production of [TNF] by LPS stimulated monocytes in a dose dependent fashion in vitro , but DIP-APC did not . Negative_regulation TNF APCS 9218575 442235 IL-2 synthesis was the most sensitive , as stimulation of IL-4 treated Tc1 cells with higher numbers of partially *restored* IFN-gamma , [TNF] , and IL-10 , but not IL-2 , synthesis . Negative_regulation TNF APOA1 12928846 1132042 *inhibited* the release of serum [TNF-Alpha] and improved the survival rates of rats with endotoxemia . Negative_regulation TNF APOA1 16574162 1562426 To investigate the mechanisms , we measured tumor necrosis factor alpha (TNF-alpha) , interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) levels in the serum and bronchoalveolar lavage (BAL) fluid and found that could significantly *inhibit* LPS induced increases in the IL-1beta and [TNF-alpha] levels in serum ( P < 0.05 , respectively ) , as well as in the IL-1beta , TNF-alpha , and IL-6 levels in BAL fluid ( P < 0.01 and P < 0.05 , P < 0.05 , respectively ) . Negative_regulation TNF APOA1 18501625 1928137 We found that could attenuate LTA induced acute lung injury and inflammation and significantly *inhibit* LTA induced IL-1beta and [TNF-alpha] accumulation in the serum ( P < 0.01 and P < 0.05 , respectively ) , as well as in bronchoalveolar lavage (BAL) fluid ( P < 0.01 and P < 0.05 , respectively ) . Negative_regulation TNF APOB 15662752 1350336 It became known , that oxidized can *inhibit* LPS induced binding of the NF-kappaB to DNA and the subsequent expression of [TNF-alpha] and interleukin-1beta in macrophages as well as oxidized LDL modulates activation of NF-kappaB in mononuclear phagocytes by altering the degradation of I-kappaBs . Negative_regulation TNF APOB 19132242 2005587 Unexpectedly , the modified not only failed to activate NF-kappaB , but completely *blocked* its activation by [tumour necrosis factor-alpha (TNF-alpha)] in EA.hy926-cells , as assessed by electrophoretic mobility shift assays and immunofluorescence . Negative_regulation TNF APOB 22241121 2519615 High-density *prevents* SAA induced production of [TNF-a] in THP-1 monocytic cells and peripheral blood mononuclear cells . Negative_regulation TNF APOB 7475000 326636 Reconstituted high-density *reduces* LPS stimulated [TNF alpha] . Negative_regulation TNF APOB 7475000 326638 Reconstituted high-density lipoprotein ( rHDL ) , an artificial consisting of apolipoprotein A-I and phosphatidylcholine ( 1 : 150 , molar ratios ) dose-dependently *reduces* lipopolysaccharide (LPS) induced [tumor necrosis factor-alpha (TNF)] production in in vitro , ex-vivo , and in-vivo model systems . Negative_regulation TNF APOB 8304830 249015 Reconstituted high density *inhibits* physiologic and [tumor necrosis factor] alpha responses to lipopolysaccharide in rabbits . Negative_regulation TNF APOB 8324886 223316 A reconstituted , apolipoprotein A-I containing *reduces* [tumor necrosis factor] release and attenuates shock in endotoxemic rabbits . Negative_regulation TNF APOB 8690807 372650 Oxidized low density *inhibits* lipopolysaccharide induced binding of nuclear factor-kappaB to DNA and the subsequent expression of [tumor necrosis factor-alpha] and interleukin-1beta in macrophages . Negative_regulation TNF APOB 9811529 545730 At least 4-8-h preincubation of LPS with either LDL or HDL were necessary to inhibit 50 % of the LPS induced TNF-alpha production by human peripheral blood mononuclear cells ( PBMC ) , whereas after 24 h of preincubation or HDL strongly *inhibited* the [TNF-alpha] synthesis ( 70-90 % , P < 0.01 ) . Negative_regulation TNF APOB 9863542 556103 In addition , *inhibited* IL-1 and [TNF] production and the expression of CD11a , CD11b , CD11c and CD14 by the mononuclear cells of FH patients and this may be an additional beneficial effect of LDL-apheresis apart of decreasing LDL concentrations . Negative_regulation TNF APOE 23619428 2795423 We observed that the absence of *resulted* in the increased proportion of Th1 and Th17 cells in the spleens and brains , as well as up-regulated expressions of proinflammatory cytokines ( IL-17 , IFN-? , [TNF-a] , IL-12 , IL-1ß and IL-6 ) and transcription factors ( ROR?t and T-bet ) in the CNS . Negative_regulation TNF ARG1 17218616 1732540 Our results demonstrate that reduction of activity enhanced cellular content of NO and S-nitrosated proteins , and *resulted* in decreases in [TNF-alpha-] or LPS stimulated NF-kappaB DNA binding and transcriptional activity , in association with enhanced S-nitrosation of p50 . Negative_regulation TNF ARG1 21617140 2454469 Quantitative reverse transcription-polymerase chain reaction and Western blot analysis demonstrated that *inhibited* [tumor necrosis factor-a] production induced by lipopolysaccharide in human aortic smooth muscle cells . Negative_regulation TNF ARG2 17218616 1732541 Our results demonstrate that reduction of activity enhanced cellular content of NO and S-nitrosated proteins , and *resulted* in decreases in [TNF-alpha-] or LPS stimulated NF-kappaB DNA binding and transcriptional activity , in association with enhanced S-nitrosation of p50 . Negative_regulation TNF ARSA 11775855 581319 Both DEX and could inhibit the activation of NF-kappa B and *reduce* the release of [TNF-alpha] . Negative_regulation TNF ARSA 1906437 161730 Finally , the 5-lipoxygenase inhibitors , ketoconazole and L-656,224 , but not the cyclo-oxygenase inhibitor , *inhibited* [TNF] stimulated by all agents . Negative_regulation TNF ARSB 19379723 2081941 , a phosphodiesterase 7A inhibitor , *reduces* cutaneous [TNF-alpha] level and ameliorates skin edema in phorbol ester 12-O-tetradecanoylphorbol-13-acetate induced skin inflammation model in mice . Negative_regulation TNF ARSD 22963993 2673375 Subsequently , the *inhibited* the activation of glial cells and the expression of [tumor necrosis factor (TNF)-a] , interleukin-1 beta ( IL-1ß ) and cyclooxygenase-2 (COX-2) in rat brain . Negative_regulation TNF ASAP1 21644032 2475777 Silencing of with small interfering RNA *enhanced* the production of [tumor necrosis factor-a] , interleukin 6 , interferon-ß , and nitric oxide in response to LPS . Negative_regulation TNF ASAP2 15870231 1439692 *prevented* [TNF-alpha] induced NFkappaB activation in monocytic , epithelial , and endothelial cells and reduced proinflammatory cytokine mRNA levels and adhesion molecule expression . Negative_regulation TNF ASAP2 22419609 2668916 Ectopic expression of *resulted* in attenuation of oxidative damage , reduction of [TNF-a] and IL-6 expression , and elevation of epithelial proliferation in colonic mucosa and led to decreased apoptosis and increased proliferation in colonic adenocarcinoma cells . Negative_regulation TNF ASH1L 24012418 2841848 Here we report that , a H3K4 methyltransferase , *suppressed* interleukin-6 (IL-6) , and [tumor necrosis factor (TNF)] production in Toll-like receptor (TLR) triggered macrophages , protecting mice from sepsis . Negative_regulation TNF ATF2 10318823 611907 At the same time , either truncated or full-length forms of *reduced* UVC induced activation of the [tumor necrosis factor-alpha (TNFalpha)] promoter and decreased expression of TNFalpha . Negative_regulation TNF ATF2 20663042 2298139 These results indicated that the downregulation of [TNF-alpha] by S. tenuifolia water extract may have *involved* the inhibition of both IkappaBalpha degradation and activation of c-Jun and involving suppression of JNK/SAPK . Negative_regulation TNF ATF3 19478204 2102424 Importantly , , when induced by saturated fatty acids , can transcriptionally *repress* [tumor necrosis factor-alpha] production in macrophages in vitro . Negative_regulation TNF ATL1 19262506 2055518 also *attenuated* [tumor necrosis factor-alpha (TNF-alpha)] and interferon-gamma (IFN-gamma) production , which was inhibited by an A ( 2A ) AR antagonist . Negative_regulation TNF ATL1 19766323 2216852 The results indicate that significantly *reduces* LPS induced expression of COX-2 and [TNF-alpha] , enhances the expression of IL-10 and IL-8 , but does not alter the expression of IL-1beta . Negative_regulation TNF ATL2 19262506 2055519 also *attenuated* [tumor necrosis factor-alpha (TNF-alpha)] and interferon-gamma (IFN-gamma) production , which was inhibited by an A ( 2A ) AR antagonist . Negative_regulation TNF ATL2 19766323 2216853 The results indicate that significantly *reduces* LPS induced expression of COX-2 and [TNF-alpha] , enhances the expression of IL-10 and IL-8 , but does not alter the expression of IL-1beta . Negative_regulation TNF ATL3 19262506 2055520 also *attenuated* [tumor necrosis factor-alpha (TNF-alpha)] and interferon-gamma (IFN-gamma) production , which was inhibited by an A ( 2A ) AR antagonist . Negative_regulation TNF ATL3 19766323 2216854 The results indicate that significantly *reduces* LPS induced expression of COX-2 and [TNF-alpha] , enhances the expression of IL-10 and IL-8 , but does not alter the expression of IL-1beta . Negative_regulation TNF ATM 14599555 1161287 Apoptosis effected by [TNF-alpha] alone was suppressed in the *presence* of , and this effect appeared essentially characterized by : ( i ) phosphorylation of phosphatidylinositol-3 kinase (PI-3K) , influencing in turn protein kinase B/Akt ( Akt ) and Bad phosphorylation ; Negative_regulation TNF ATM 17125837 1686462 After expression and purification in Escherichia coli , could bind directly with TNF-alpha and *inhibit* the binding of [TNF-alpha] to its two receptors , TNFR1 and TNFR2 . Negative_regulation TNF ATP5O 19895474 2161648 and the pretreatments from these agents significantly restored Na ( + ) -K ( + ) <-ATPase> activity , *suppressed* caspase-3 activity and release of IL-1 , IL-6 , and [TNF-alpha] ( P < 0.05 ) . Negative_regulation TNF ATP5O 22090321 2509127 While plasma amylase , lipase , IL-1ß , and [TNF-a] levels , and tissue MDA and MPO levels significantly increased in rats with cerulean induced AP , tissue GSH and activity significantly *reduced* . Negative_regulation TNF ATP5O 22351078 2561116 Inhibition of *promotes* myocardial [tumor necrosis factor-alpha] protein expression and cardiac dysfunction via calcium/mTOR signaling in endotoxemia . Negative_regulation TNF ATP5O 22351078 2561120 The aim of this study was to investigate the *role* of signaling in myocardial [TNF-a] expression during endotoxemia . Negative_regulation TNF ATP5O 9754866 535248 inhibitors and PKC activation synergistically *stimulate* [TNF-alpha] production in RBL-2H3 cells . Negative_regulation TNF ATP5O 9754866 535254 These results suggest 1 ) that [ Ca2+ ] i increase and subsequent activation of protein kinase C is necessary for the release of TNF-alpha , and they work synergistically , 2 ) that the [TNF-alpha] release *induced* by inhibitors can be regulated at the transcriptional level . Negative_regulation TNF ATP5O 9865597 556277 The release of [TNF-alpha] *required* both a Ca2 ( + ) <-ATPase> inhibitor and 12-O-tetradecanoylphorbol-13-acetate ( TPA ) . Negative_regulation TNF ATP8A2 15333044 1290964 IL-1beta , IL-6 and TNF-alpha concentrations in supernatants of LPS stimulated mononuclear cells were not influenced by the addition of N , O-sulfated K5 polysaccharide ( K5-N , OS ) and epimerized N-sulfated K5 polysaccharide ( K5 NS epi ) at 5 and 10 microg mL(-1) , whereas the addition of epimerized N , O-sulfated K5 polysaccharide ( K5-N , OS epi ) ( 5 and 10 microg ) and O-sulfated K5 polysaccharide ( K5-OS ) ( 5 and 10 microg mL(-1) ) to LPS stimulated cells *caused* a significant dose dependent inhibition of IL-1beta , IL-6 and [TNF-alpha] . Negative_regulation TNF ATP8A2 18088351 1868591 Although 2 U AT slightly *inhibited* [TNF-alpha] production by LPS stimulated monocytes , it significantly inhibited TNF-alpha production in the presence of a low concentration of beraprost , a stable derivative of prostacyclin . Negative_regulation TNF ATP8A2 9772703 408318 ) significantly *inhibited* LPS induced [TNF] release from mouse peritoneal macrophage in a concentration dependent manner . Negative_regulation TNF AXL 16831897 1591470 Suppression of [TNFalpha] production was *mediated* by induction and activation of the and downstream induction of Twist transcriptional repressors that bind to E box elements in the TNF promoter and suppress NF-kappaB dependent transcription . Negative_regulation TNF AZU1 22342671 2571970 penetrated the cell membrane during the 10 min treatment and *reduced* the LPS induced production of nitric oxide ( NO ) , inducible nitric oxide synthase (iNOS) , and cytokines ( [TNF-a] and IL-6 ) in a concentration dependent manner . Negative_regulation TNF BAD 12023375 943780 , an essential virulence factor of Blastomyces dermatitidis , *suppresses* host [TNF-alpha] production through TGF-beta dependent and -independent mechanisms . Negative_regulation TNF BAD 12023375 943781 Similarly , addition of anti-TGF-beta mAb into cultures of phagocytes and wild-type yeast reversed *inhibition* of [TNF-alpha] production . Negative_regulation TNF BAD 12023375 943782 However , in contrast to yeast cell surface BAD1 , which induced TGF-beta , soluble BAD1 failed to do so and [TNF-alpha] suppression *mediated* by soluble was unaffected by neutralization of TGF-beta . Negative_regulation TNF BAD 12023375 943783 Thus , of B. dermatitidis *induces* suppression of [TNF-alpha] and progressive infection by both TGF-beta dependent and -independent mechanisms . Negative_regulation TNF BAD 15585870 1345826 binds yeast to macrophages ( Mphi ) via CR3 and CD14 and *suppresses* [TNF-alpha] , which is required for resistance . Negative_regulation TNF BAX 10416602 631432 The threshold temperature for the onset of apoptosis was 42 degrees C. Whereas hyperthermia exerted no effect on the expression of Bcl-2 and , heat *induced* a > 30-fold increase of [tumor necrosis factor (TNF)] alpha mRNA expression and a significant increase in TNF-alpha protein secretion . Negative_regulation TNF BCL10 7540278 307210 and Bcl-2 *inhibit* [TNF] and Fas induced apoptosis and activation of phospholipase A2 in breast carcinoma cells . Negative_regulation TNF BCL10 9311830 455067 Moreover , the mechanism of action of BHRF1 resembled that of Bcl-2 and as it *inhibited* [TNF-] and anti-Fas induced activation of two enzymes participating in the apoptosis pathway , cytosolic phospholipase A2 and caspase-3/CPP32 , but did not interfere with the activation of NF-kappaB-like transcription factors . Negative_regulation TNF BCL10 9314949 455733 [TNF] + cer killing , which can affect more than 50 % of EC , is not effectively inhibited by CrmA or Z-VAD frank , but can be readily *blocked* by Bcl-2 , , or A1 . Negative_regulation TNF BCL2 10416602 631433 The threshold temperature for the onset of apoptosis was 42 degrees C. Whereas hyperthermia exerted no effect on the expression of and Bax , heat *induced* a > 30-fold increase of [tumor necrosis factor (TNF)] alpha mRNA expression and a significant increase in TNF-alpha protein secretion . Negative_regulation TNF BCL2 12057915 952251 Preconditioning and , respectively , *reduced* the increased [tumor necrosis factor (TNF)] and macrophage inflammatory protein-2 (MIP)-2 levels observed after hepatic reperfusion . Negative_regulation TNF BCL2 14667973 1178036 Treatment with P4 augmented EGF and protein expression , but *inhibited* IGF-I and [TNFalpha] expression in cultured leiomyoma cells . Negative_regulation TNF BCL2 7540278 307211 Bcl-x and *inhibit* [TNF] and Fas induced apoptosis and activation of phospholipase A2 in breast carcinoma cells . Negative_regulation TNF BCL2 9311830 455068 Moreover , the mechanism of action of BHRF1 resembled that of Bcl-2 and as it *inhibited* [TNF-] and anti-Fas induced activation of two enzymes participating in the apoptosis pathway , cytosolic phospholipase A2 and caspase-3/CPP32 , but did not interfere with the activation of NF-kappaB-like transcription factors . Negative_regulation TNF BCL2 9314949 455734 [TNF] + cer killing , which can affect more than 50 % of EC , is not effectively inhibited by CrmA or Z-VAD frank , but can be readily *blocked* by Bcl-2 , , or A1 . Negative_regulation TNF BCL3 12907458 1163975 These findings suggest that IL-10 induced is *required* for suppression of [TNF-alpha] production in macrophages . Negative_regulation TNF BCL3 15465827 1335097 Forced expression of *suppressed* LPS induced transcription from the [TNFalpha] promoter and inhibited two artificial promoters composed of TNFalphakappaB sites that preferentially bind p50 dimers . Negative_regulation TNF BCL3 15465827 1335098 Analysis of macrophages from p50 and BCL-3 knock-out mice revealed that both transcription factors negatively regulate [TNFalpha] expression and that *inhibits* IL-1alpha and IL-1beta . Negative_regulation TNF BCL3 9311830 455069 Moreover , the mechanism of action of BHRF1 resembled that of Bcl-2 and as it *inhibited* [TNF-] and anti-Fas induced activation of two enzymes participating in the apoptosis pathway , cytosolic phospholipase A2 and caspase-3/CPP32 , but did not interfere with the activation of NF-kappaB-like transcription factors . Negative_regulation TNF BCL3 9314949 455735 [TNF] + cer killing , which can affect more than 50 % of EC , is not effectively inhibited by CrmA or Z-VAD frank , but can be readily *blocked* by Bcl-2 , , or A1 . Negative_regulation TNF BCL5 9311830 455064 Moreover , the mechanism of action of BHRF1 resembled that of Bcl-2 and as it *inhibited* [TNF-] and anti-Fas induced activation of two enzymes participating in the apoptosis pathway , cytosolic phospholipase A2 and caspase-3/CPP32 , but did not interfere with the activation of NF-kappaB-like transcription factors . Negative_regulation TNF BCL5 9314949 455730 [TNF] + cer killing , which can affect more than 50 % of EC , is not effectively inhibited by CrmA or Z-VAD frank , but can be readily *blocked* by Bcl-2 , , or A1 . Negative_regulation TNF BCL6 9311830 455065 Moreover , the mechanism of action of BHRF1 resembled that of Bcl-2 and as it *inhibited* [TNF-] and anti-Fas induced activation of two enzymes participating in the apoptosis pathway , cytosolic phospholipase A2 and caspase-3/CPP32 , but did not interfere with the activation of NF-kappaB-like transcription factors . Negative_regulation TNF BCL6 9314949 455731 [TNF] + cer killing , which can affect more than 50 % of EC , is not effectively inhibited by CrmA or Z-VAD frank , but can be readily *blocked* by Bcl-2 , , or A1 . Negative_regulation TNF BCL9 9311830 455066 Moreover , the mechanism of action of BHRF1 resembled that of Bcl-2 and as it *inhibited* [TNF-] and anti-Fas induced activation of two enzymes participating in the apoptosis pathway , cytosolic phospholipase A2 and caspase-3/CPP32 , but did not interfere with the activation of NF-kappaB-like transcription factors . Negative_regulation TNF BCL9 9314949 455732 [TNF] + cer killing , which can affect more than 50 % of EC , is not effectively inhibited by CrmA or Z-VAD frank , but can be readily *blocked* by Bcl-2 , , or A1 . Negative_regulation TNF BDNF 21034794 2370079 *suppressed* [tumor necrosis factor-a] and mRNA expression while increasing the interleukin10 and mRNA expression . Negative_regulation TNF BIRC2 11373338 817852 In mesangial cells , interleukin-1beta (IL-1beta) and [tumor necrosis factor-alpha] *induced* cellular inhibitor of apoptosis 1 ( ) mRNA expression within 3 h . Negative_regulation TNF BIRC3 9726225 529714 Because may be *involved* in the regulation of [TNF-alpha] signaling , this raises the possibility that depot-specific differences may exist in the regulation of adipocyte apoptosis . Negative_regulation TNF BMP1 16478754 1604141 Antipsychotic drugs and significantly *reduced* the levels of [TNF] in the prefrontal cortex compared to vehicle treated animals , whilst other cytokines remained unchanged . Negative_regulation TNF BMP4 24751878 2943439 LDN-193189 prevented *mediated* inhibition of basal and [tumor necrosis factor] a-stimulated expression of IL8 in AGS cells . Negative_regulation TNF BMP7 18496506 1965455 *inhibited* [TNF-alpha] release from polymeric IgA stimulated mesangial cells by activation of PPAR-gamma but suppressed TGF-beta release by mechanisms independent of PPAR-gamma . Negative_regulation TNF BMP7 24751878 2943438 BMP-4 , BMP-2 , and *inhibited* basal and [tumor necrosis factor] a-stimulated expression of IL8 in canine gastric epithelial cells . Negative_regulation TNF BPI 11876922 893904 The abilities of porcine to combine endotoxin ( lipopolysaccharide , LPS ) and *inhibit* the release of [TNFalpha] from hepatic Kupffer 's cells were examined . Negative_regulation TNF BPI 1522221 197068 [TNF] release induced by K. pneumoniae and P. aeruginosa was also *inhibited* by both and fragment but , at the protein concentrations tested , P. aeruginosa was killed only by the fragment and K. pneumoniae was not killed by either protein . Negative_regulation TNF BPI 1729370 180973 For example , *blocks* LPS stimulated [TNF] release in vitro and in vivo , and LPS complexed to BPI is not pyrogenic in rabbits . Negative_regulation TNF BPI 8409400 233337 LBP was shown to *enhance* LPS induced [TNF-alpha] , IL-6 , and IL-8 release by mononuclear phagocytic cells , whereas inhibited the release of these cytokines . Negative_regulation TNF BPI 9725255 529649 We have demonstrated that , unlike the human monocyte response to LPS , both LBP and *inhibited* LPS stimulated [TNF-alpha] production in mouse peritoneal macrophages . Negative_regulation TNF BPIFA1 23721177 2860934 The binding of also *attenuated* SWCNT induced [TNF-a] secretion by RAW 264.7 macrophages . Negative_regulation TNF BRAP 1563780 184884 Neither PI nor *diminished* [TNF] production in response to LPS , in contrast to a platelet activating factor antagonist [ 1-O-hexadecyl-2-acetyl- sn-glycero-3-phospho ( N , N,N-trimethyl hexanolamine ) ] which inhibited both exoantigen- and LPS induced production of TNF . Negative_regulation TNF BRD1 22189182 2520321 also *inhibited* [TNF-a] and IL-6 expression in LPS stimulated BMDCs . Negative_regulation TNF BTK 12810683 1102841 In addition , adenoviral overexpression of in normal human monocytes *enhanced* [TNF alpha] production . Negative_regulation TNF BTK 12810683 1102842 We examined the *role* of in [TNF alpha] production using luciferase reporter adenoviral constructs and have established that overexpression of Btk results in the stabilization of TNF alpha mRNA via the 3 ' untranslated region . Negative_regulation TNF BTK 17725607 1848794 In this study we set out to investigate the potential *role* of in Toll-like receptor 9 (TLR9) activation and the production of pro-inflammatory cytokines such as interleukin (IL)-6 , [tumour necrosis factor (TNF)-alpha] and IL-12p40 . Negative_regulation TNF C12orf57 10657659 664131 However , coadministrating TL2 .1 and <3C10> *inhibited* the [TNF] response by 80 % . Negative_regulation TNF C12orf57 21132269 2372987 The activation of nuclear factor of ? light polypeptide gene enhancer in B-cells inhibitor , a , by [tumor necrosis factor-a] or VEGF in these cells was also *blocked* by . Negative_regulation TNF C1QA 8225388 234851 Inhibitor of C1q secretion suppresses the macrophage response to lipid A for nitric oxide but not for TNF production : evidence for a *role* of in autocrine binding of [TNF] . Negative_regulation TNF C1QA 8603439 352185 The *role* of complement subcomponent in the modulation of [TNF-alpha] binding to L929 cells to mediate cytotoxicity and nitric oxide ( NO ) generation was investigated . Negative_regulation TNF C1QB 8225388 234852 Inhibitor of C1q secretion suppresses the macrophage response to lipid A for nitric oxide but not for TNF production : evidence for a *role* of in autocrine binding of [TNF] . Negative_regulation TNF C1QB 8603439 352186 The *role* of complement subcomponent in the modulation of [TNF-alpha] binding to L929 cells to mediate cytotoxicity and nitric oxide ( NO ) generation was investigated . Negative_regulation TNF C1QTNF3 19955001 2190768 *inhibits* LPS induced IL-6 and [TNF] release . Negative_regulation TNF C3 23168409 2729756 Peroxisome proliferator activated receptor a positively regulates expression but *inhibits* [tumor necrosis factor] a-mediated activation of C3 gene in mammalian hepatic derived cells . Negative_regulation TNF C3 8617973 353950 In nonadherent PBMC , *suppressed* LPS induced synthesis of [TNF-alpha] ( 20-71 % decrease by 0.2-10 microgram/ml of C3a , p less than 0.01 ) and IL-1 beta ( 19-57 % decrease by 0.5-10 microgram/ml of C3a , p less than 0.01 ) , independently of endogenous production of PGE2 . Negative_regulation TNF C3 8617973 353952 also *suppressed* LPS induced mRNA levels for [TNF-alpha] and IL-1 beta . Negative_regulation TNF CA1 21767946 2579282 The results showed that could *inhibit* [tumour necrosis factor-a (TNF-a)] production in macrophages in various environments , including those isolated from peritoneal cavity of adjuvant induced arthritis ( AA ) rats , from Lewis lung carcinoma ( LLC ) transplanted tumours and those induced by LLC cells in vitro . Negative_regulation TNF CA1 22553216 2624989 *inhibited* the production of [TNF-a] , IL-1ß , and IL-6 in serum , supernatant of peritoneal macrophages , and lamina propria . Negative_regulation TNF CA1 9872684 556935 We sought to determine whether inhibition with acetazolamide would *prevent* CO2 mediated inhibition of LPS stimulated [TNF] release . Negative_regulation TNF CA10 9872684 556936 We sought to determine whether inhibition with acetazolamide would *prevent* CO2 mediated inhibition of LPS stimulated [TNF] release . Negative_regulation TNF CA11 9872684 556937 We sought to determine whether inhibition with acetazolamide would *prevent* CO2 mediated inhibition of LPS stimulated [TNF] release . Negative_regulation TNF CA12 9872684 556938 We sought to determine whether inhibition with acetazolamide would *prevent* CO2 mediated inhibition of LPS stimulated [TNF] release . Negative_regulation TNF CA13 9872684 556947 We sought to determine whether inhibition with acetazolamide would *prevent* CO2 mediated inhibition of LPS stimulated [TNF] release . Negative_regulation TNF CA14 9872684 556939 We sought to determine whether inhibition with acetazolamide would *prevent* CO2 mediated inhibition of LPS stimulated [TNF] release . Negative_regulation TNF CA2 9754866 535247 inhibitors and PKC activation synergistically *stimulate* [TNF-alpha] production in RBL-2H3 cells . Negative_regulation TNF CA2 9754866 535253 These results suggest 1 ) that [ Ca2+ ] i increase and subsequent activation of protein kinase C is necessary for the release of TNF-alpha , and they work synergistically , 2 ) that the [TNF-alpha] release *induced* by inhibitors can be regulated at the transcriptional level . Negative_regulation TNF CA2 9865597 556276 The release of [TNF-alpha] *required* both a ( + ) -ATPase inhibitor and 12-O-tetradecanoylphorbol-13-acetate ( TPA ) . Negative_regulation TNF CA2 9872684 556940 We sought to determine whether inhibition with acetazolamide would *prevent* CO2 mediated inhibition of LPS stimulated [TNF] release . Negative_regulation TNF CA3 9872684 556941 We sought to determine whether inhibition with acetazolamide would *prevent* CO2 mediated inhibition of LPS stimulated [TNF] release . Negative_regulation TNF CA4 9872684 556942 We sought to determine whether inhibition with acetazolamide would *prevent* CO2 mediated inhibition of LPS stimulated [TNF] release . Negative_regulation TNF CA6 9872684 556943 We sought to determine whether inhibition with acetazolamide would *prevent* CO2 mediated inhibition of LPS stimulated [TNF] release . Negative_regulation TNF CA7 9872684 556944 We sought to determine whether inhibition with acetazolamide would *prevent* CO2 mediated inhibition of LPS stimulated [TNF] release . Negative_regulation TNF CA8 9872684 556945 We sought to determine whether inhibition with acetazolamide would *prevent* CO2 mediated inhibition of LPS stimulated [TNF] release . Negative_regulation TNF CA9 9872684 556946 We sought to determine whether inhibition with acetazolamide would *prevent* CO2 mediated inhibition of LPS stimulated [TNF] release . Negative_regulation TNF CABIN1 12100723 962429 FK506 , a , and nifedipine , a calcium channel inhibitor , *inhibited* not only the expression of [TNF-alpha] and CD40L , but also the up-regulation of CD80 on irradiated A20-HL cells . Negative_regulation TNF CADM1 9705247 525867 Selective inhibition of [TNF-alpha] *induced* gene expression by tanapox virus . Negative_regulation TNF CADM2 9705247 525865 Selective inhibition of [TNF-alpha] *induced* gene expression by tanapox virus . Negative_regulation TNF CADM3 9705247 525864 Selective inhibition of [TNF-alpha] *induced* gene expression by tanapox virus . Negative_regulation TNF CADM4 9705247 525866 Selective inhibition of [TNF-alpha] *induced* gene expression by tanapox virus . Negative_regulation TNF CALB1 15225809 1268469 Our findings suggest that is capable of directly inhibiting the activity of caspase-3 , a common downstream effector of multiple apoptotic signaling pathways , and that this inhibition *results* in an inhibition of [tumor necrosis factor] ( TNFalpha ) and glucocorticoid induced apoptosis in bone cells . Negative_regulation TNF CALCB 17923674 1813169 alphaCGRP and equally *suppressed* the production of [TNF-alpha] and IL-12 in bone marrow derived dendritic cells stimulated with lipopolysaccharide . Negative_regulation TNF CALM3 16421203 1554190 Increasing the level of cellular by stable transfection *results* in reductions in LPS induced expression of [TNF] and iNOS , along with reduced activation of their transcriptional regulators and concomitant protection against apoptosis . Negative_regulation TNF CALM3 23199585 2763726 and AZM *induced* a dose dependent suppression of spontaneous [TNF-a] , sTNFR2 , IL-6 , IL-8 and CCL18 production ( p < 0.05 ) . Negative_regulation TNF CALM3 23199585 2763734 also *inhibited* the LPS stimulated [TNF-a] , IL-1ß , IL-6 and IL-10 production . Negative_regulation TNF CALR 21803152 2521599 Enolase 1 and siRNA *reduced* the [ Ca ( 2+ ) ] i levels , amounts of total TNF-a , and the release of [TNF-a] and leukotrienes , all of which are increased in the BMMCs activated with antigen/antibody reaction . Negative_regulation TNF CAMK4 20954187 2382141 inhibition in MRL/lpr mice *resulted* in significant suppression of nephritis and skin disease , decreased expression of the costimulatory molecules CD86 and CD80 on B cells , and suppression of IFN? and [tumor necrosis factor] a production . Negative_regulation TNF CAMP 16456005 1522358 almost completely *prevented* the release of [TNF-alpha] and other cytokines by human PBMC following stimulation with LPS and other TLR2/4 and TLR9 agonists , but not with cytokines TNF-alpha or IL-1beta . Negative_regulation TNF CAMP 21441450 2417074 dramatically *reduced* [TNF-a] and NO levels produced by LPS and IFN-? polarized M1-BMDM and slightly reduced reactive oxygen species production by these cells . Negative_regulation TNF CAMP 21441450 2417077 significantly *reduced* LPS induced [TNF-a] secretion in ex vivo alveolar macrophages , whereas its effect on peritoneal macrophages was much less dramatic . Negative_regulation TNF CAMP 9169746 432886 Both ( 106-138 ) and CAP18 ( 106-138 ) -IgG significantly *suppressed* LPS induced [tumor necrosis factor (TNF)] production in whole blood in the absence of anticoagulants . Negative_regulation TNF CARD8 22711073 2621312 *Role* of NLRP3 and in the regulation of [TNF-a] induced IL-1ß release in vascular smooth muscle cells . Negative_regulation TNF CARHSP1 21078874 2371615 Transfecting into RAW264.7 cells *results* in an increase in [TNF-a] 3'UTR luciferase expression in resting cells and CARHSP1 knockdown LPS stimulated cells . Negative_regulation TNF CASP1 11562122 862737 When compared to untreated cells , these analyses also showed dose dependent increases in [TNF-alpha] *induced* apoptosis in both chondrocyte populations , with increases in the levels of activity for all doses of TNF-alpha ( from approximately 5 to approximately 20 fold ) . Negative_regulation TNF CASP1 18054255 1918835 As quantified by flow cytometry , [TNF-alpha+Ro] *induced* a higher level of caspase-3 and -8 activation than that seen with IL-1beta+Ro. Pre-incubation for 2h with caspase inhibitors for caspase-3 , -7 , -8 and significantly decreased the hypodiploid DNA peak induced by treatment with TNF-alpha+Ro at 24 h. Indomethacin increased the cell death induced by IL-1beta+Ro ; Negative_regulation TNF CASP1 18258721 1895967 [Tumor necrosis factor-alpha] inhibition of skeletal muscle regeneration is *mediated* by a dependent stem cell response . Negative_regulation TNF CASP1 22848449 2635883 We demonstrate that T cells lacking the regulatory subunit of IKK , NF?B essential modifier (NEMO) , are hypersensitive to programmed necrosis when stimulated with [TNF] in the *presence* of inhibitors . Negative_regulation TNF CASP10 18054255 1918836 As quantified by flow cytometry , [TNF-alpha+Ro] *induced* a higher level of caspase-3 and -8 activation than that seen with IL-1beta+Ro. Pre-incubation for 2h with caspase inhibitors for caspase-3 , -7 , -8 and significantly decreased the hypodiploid DNA peak induced by treatment with TNF-alpha+Ro at 24 h. Indomethacin increased the cell death induced by IL-1beta+Ro ; Negative_regulation TNF CASP10 18258721 1895968 [Tumor necrosis factor-alpha] inhibition of skeletal muscle regeneration is *mediated* by a dependent stem cell response . Negative_regulation TNF CASP10 22848449 2635884 We demonstrate that T cells lacking the regulatory subunit of IKK , NF?B essential modifier (NEMO) , are hypersensitive to programmed necrosis when stimulated with [TNF] in the *presence* of inhibitors . Negative_regulation TNF CASP12 18054255 1918846 As quantified by flow cytometry , [TNF-alpha+Ro] *induced* a higher level of caspase-3 and -8 activation than that seen with IL-1beta+Ro. Pre-incubation for 2h with caspase inhibitors for caspase-3 , -7 , -8 and significantly decreased the hypodiploid DNA peak induced by treatment with TNF-alpha+Ro at 24 h. Indomethacin increased the cell death induced by IL-1beta+Ro ; Negative_regulation TNF CASP12 18258721 1895978 [Tumor necrosis factor-alpha] inhibition of skeletal muscle regeneration is *mediated* by a dependent stem cell response . Negative_regulation TNF CASP12 22848449 2635894 We demonstrate that T cells lacking the regulatory subunit of IKK , NF?B essential modifier (NEMO) , are hypersensitive to programmed necrosis when stimulated with [TNF] in the *presence* of inhibitors . Negative_regulation TNF CASP14 18054255 1918837 As quantified by flow cytometry , [TNF-alpha+Ro] *induced* a higher level of caspase-3 and -8 activation than that seen with IL-1beta+Ro. Pre-incubation for 2h with caspase inhibitors for caspase-3 , -7 , -8 and significantly decreased the hypodiploid DNA peak induced by treatment with TNF-alpha+Ro at 24 h. Indomethacin increased the cell death induced by IL-1beta+Ro ; Negative_regulation TNF CASP14 18258721 1895969 [Tumor necrosis factor-alpha] inhibition of skeletal muscle regeneration is *mediated* by a dependent stem cell response . Negative_regulation TNF CASP14 22848449 2635885 We demonstrate that T cells lacking the regulatory subunit of IKK , NF?B essential modifier (NEMO) , are hypersensitive to programmed necrosis when stimulated with [TNF] in the *presence* of inhibitors . Negative_regulation TNF CASP16 18054255 1918847 As quantified by flow cytometry , [TNF-alpha+Ro] *induced* a higher level of caspase-3 and -8 activation than that seen with IL-1beta+Ro. Pre-incubation for 2h with caspase inhibitors for caspase-3 , -7 , -8 and significantly decreased the hypodiploid DNA peak induced by treatment with TNF-alpha+Ro at 24 h. Indomethacin increased the cell death induced by IL-1beta+Ro ; Negative_regulation TNF CASP16 18258721 1895979 [Tumor necrosis factor-alpha] inhibition of skeletal muscle regeneration is *mediated* by a dependent stem cell response . Negative_regulation TNF CASP16 22848449 2635895 We demonstrate that T cells lacking the regulatory subunit of IKK , NF?B essential modifier (NEMO) , are hypersensitive to programmed necrosis when stimulated with [TNF] in the *presence* of inhibitors . Negative_regulation TNF CASP2 18054255 1918838 As quantified by flow cytometry , [TNF-alpha+Ro] *induced* a higher level of caspase-3 and -8 activation than that seen with IL-1beta+Ro. Pre-incubation for 2h with caspase inhibitors for caspase-3 , -7 , -8 and significantly decreased the hypodiploid DNA peak induced by treatment with TNF-alpha+Ro at 24 h. Indomethacin increased the cell death induced by IL-1beta+Ro ; Negative_regulation TNF CASP2 18258721 1895970 [Tumor necrosis factor-alpha] inhibition of skeletal muscle regeneration is *mediated* by a dependent stem cell response . Negative_regulation TNF CASP2 22848449 2635886 We demonstrate that T cells lacking the regulatory subunit of IKK , NF?B essential modifier (NEMO) , are hypersensitive to programmed necrosis when stimulated with [TNF] in the *presence* of inhibitors . Negative_regulation TNF CASP3 18054255 1918839 As quantified by flow cytometry , [TNF-alpha+Ro] *induced* a higher level of and -8 activation than that seen with IL-1beta+Ro. Pre-incubation for 2h with caspase inhibitors for caspase-3 , -7 , -8 and pan-caspase significantly decreased the hypodiploid DNA peak induced by treatment with TNF-alpha+Ro at 24 h. Indomethacin increased the cell death induced by IL-1beta+Ro ; Negative_regulation TNF CASP3 18258721 1895971 [Tumor necrosis factor-alpha] inhibition of skeletal muscle regeneration is *mediated* by a dependent stem cell response . Negative_regulation TNF CASP3 18496137 1944933 Compared with Control , Postcon also inhibited translocation of NF-kappa B to nuclei ( 167 % +/- 21 % vs. 142 % +/- 18 % * ) , decreased the level of plasma [TNF-alpha] ( 1,994 +/- 447 vs. 667 +/- 130* pg/mL ) , and *inhibited* activity ( 0.57 % +/- 0.1 % vs. 0.21 % +/- 0.1 % * ) . Negative_regulation TNF CASP3 22848449 2635887 We demonstrate that T cells lacking the regulatory subunit of IKK , NF?B essential modifier (NEMO) , are hypersensitive to programmed necrosis when stimulated with [TNF] in the *presence* of inhibitors . Negative_regulation TNF CASP4 18054255 1918840 As quantified by flow cytometry , [TNF-alpha+Ro] *induced* a higher level of caspase-3 and -8 activation than that seen with IL-1beta+Ro. Pre-incubation for 2h with caspase inhibitors for caspase-3 , -7 , -8 and significantly decreased the hypodiploid DNA peak induced by treatment with TNF-alpha+Ro at 24 h. Indomethacin increased the cell death induced by IL-1beta+Ro ; Negative_regulation TNF CASP4 18258721 1895972 [Tumor necrosis factor-alpha] inhibition of skeletal muscle regeneration is *mediated* by a dependent stem cell response . Negative_regulation TNF CASP4 22848449 2635888 We demonstrate that T cells lacking the regulatory subunit of IKK , NF?B essential modifier (NEMO) , are hypersensitive to programmed necrosis when stimulated with [TNF] in the *presence* of inhibitors . Negative_regulation TNF CASP5 18054255 1918841 As quantified by flow cytometry , [TNF-alpha+Ro] *induced* a higher level of caspase-3 and -8 activation than that seen with IL-1beta+Ro. Pre-incubation for 2h with caspase inhibitors for caspase-3 , -7 , -8 and significantly decreased the hypodiploid DNA peak induced by treatment with TNF-alpha+Ro at 24 h. Indomethacin increased the cell death induced by IL-1beta+Ro ; Negative_regulation TNF CASP5 18258721 1895973 [Tumor necrosis factor-alpha] inhibition of skeletal muscle regeneration is *mediated* by a dependent stem cell response . Negative_regulation TNF CASP5 22848449 2635889 We demonstrate that T cells lacking the regulatory subunit of IKK , NF?B essential modifier (NEMO) , are hypersensitive to programmed necrosis when stimulated with [TNF] in the *presence* of inhibitors . Negative_regulation TNF CASP6 18054255 1918842 As quantified by flow cytometry , [TNF-alpha+Ro] *induced* a higher level of caspase-3 and -8 activation than that seen with IL-1beta+Ro. Pre-incubation for 2h with caspase inhibitors for caspase-3 , -7 , -8 and significantly decreased the hypodiploid DNA peak induced by treatment with TNF-alpha+Ro at 24 h. Indomethacin increased the cell death induced by IL-1beta+Ro ; Negative_regulation TNF CASP6 18258721 1895974 [Tumor necrosis factor-alpha] inhibition of skeletal muscle regeneration is *mediated* by a dependent stem cell response . Negative_regulation TNF CASP6 22848449 2635890 We demonstrate that T cells lacking the regulatory subunit of IKK , NF?B essential modifier (NEMO) , are hypersensitive to programmed necrosis when stimulated with [TNF] in the *presence* of inhibitors . Negative_regulation TNF CASP7 18054255 1918843 As quantified by flow cytometry , [TNF-alpha+Ro] *induced* a higher level of caspase-3 and -8 activation than that seen with IL-1beta+Ro. Pre-incubation for 2h with caspase inhibitors for caspase-3 , -7 , -8 and significantly decreased the hypodiploid DNA peak induced by treatment with TNF-alpha+Ro at 24 h. Indomethacin increased the cell death induced by IL-1beta+Ro ; Negative_regulation TNF CASP7 18258721 1895975 [Tumor necrosis factor-alpha] inhibition of skeletal muscle regeneration is *mediated* by a dependent stem cell response . Negative_regulation TNF CASP7 22848449 2635891 We demonstrate that T cells lacking the regulatory subunit of IKK , NF?B essential modifier (NEMO) , are hypersensitive to programmed necrosis when stimulated with [TNF] in the *presence* of inhibitors . Negative_regulation TNF CASP8 11014343 736363 Interestingly , the reduced expression of LPS induced [TNFalpha] in the presence of SSZ was *restored* by inhibition of . Negative_regulation TNF CASP8 11014343 736364 Inhibition of [TNFalpha] expression in macrophages by SSZ is due to the induction of apoptosis and *involves* the activation of . Negative_regulation TNF CASP8 18054255 1918844 As quantified by flow cytometry , [TNF-alpha+Ro] *induced* a higher level of caspase-3 and -8 activation than that seen with IL-1beta+Ro. Pre-incubation for 2h with caspase inhibitors for caspase-3 , -7 , -8 and significantly decreased the hypodiploid DNA peak induced by treatment with TNF-alpha+Ro at 24 h. Indomethacin increased the cell death induced by IL-1beta+Ro ; Negative_regulation TNF CASP8 18258721 1895976 [Tumor necrosis factor-alpha] inhibition of skeletal muscle regeneration is *mediated* by a dependent stem cell response . Negative_regulation TNF CASP8 20299954 2273022 Furthermore , expression in primary CD4 T cells *results* in increased production of interleukin (IL)-2 , IL-15 and [tumor necrosis factor (TNF)] , as well as IL-1RA ; Negative_regulation TNF CASP8 22848449 2635892 We demonstrate that T cells lacking the regulatory subunit of IKK , NF?B essential modifier (NEMO) , are hypersensitive to programmed necrosis when stimulated with [TNF] in the *presence* of inhibitors . Negative_regulation TNF CASP8 23487422 2766588 We evaluated the role of TNF signaling in pulmonary edema formation in a clinically relevant mouse model of ALI induced by acid aspiration and investigated the effects of [TNF] p55 receptor deletion , *inhibition* , and alveolar macrophage depletion on alveolar epithelial function . Negative_regulation TNF CASP9 18054255 1918845 As quantified by flow cytometry , [TNF-alpha+Ro] *induced* a higher level of caspase-3 and -8 activation than that seen with IL-1beta+Ro. Pre-incubation for 2h with caspase inhibitors for caspase-3 , -7 , -8 and significantly decreased the hypodiploid DNA peak induced by treatment with TNF-alpha+Ro at 24 h. Indomethacin increased the cell death induced by IL-1beta+Ro ; Negative_regulation TNF CASP9 18258721 1895977 [Tumor necrosis factor-alpha] inhibition of skeletal muscle regeneration is *mediated* by a dependent stem cell response . Negative_regulation TNF CASP9 22848449 2635893 We demonstrate that T cells lacking the regulatory subunit of IKK , NF?B essential modifier (NEMO) , are hypersensitive to programmed necrosis when stimulated with [TNF] in the *presence* of inhibitors . Negative_regulation TNF CAST 15248852 1271243 The NF-kappaB inhibitors , 1 ( 10 microm ) , pentoxifylline ( 0.5 mm ) , pyrrolidine dithiocarbamate ( PDTC , 10 microm ) or gliotoxin ( 1 pg/mL ) *reduced* the generation of GM-CSF , [TNF-alpha] and IL-8 in parallel with their inhibition of NF-kappaB . Negative_regulation TNF CAT 16822952 1625240 The [TNF-alpha] response was *inhibited* by superoxide dismutase and suggesting apoptosis is oxidative stress related . Negative_regulation TNF CAT 16959029 1615759 Production of [TNF-alpha] and IL-1beta , measured after 24 hours of Abeta treatment , was also *prevented* by apocynin , and EUKs , but the early release ( measured after 1 hour of Abeta treatment ) of TNF-alpha was insensitive to apocynin or catalase . Negative_regulation TNF CAT 17222881 1696150 N-Acetyl-l-cysteine ( 20 mM ) , dimethyl thiourea ( 20 mM ) and ( 5 microM ) significantly *inhibited* [TNF] release by primed AMs incubated with CAPs . Negative_regulation TNF CAT 17879952 1888780 overexpression *impairs* [TNF-alpha] induced NF-kappaB activation and sensitizes MCF-7 cells against TNF-alpha . Negative_regulation TNF CAV1 11908851 923620 As a comparison , [tumor necrosis factor-a] *induced* a decrease of in the cells . Negative_regulation TNF CAV1 18803934 1965114 The *role* of fatty acids and in [tumor necrosis factor] alpha induced endothelial cell activation . Negative_regulation TNF CBL 15755562 1380280 This deregulation of the balance between [TNF-alpha] and EGF synthesis *induced* by deficiency has been verified in the sera of patients with pernicious anemia ( but not in those with iron-deficient anemia ) , and in the cerebrospinal fluid (CSF) of SCD patients . Negative_regulation TNF CBL 18183619 1890051 As we have previously demonstrated that deficiency *increases* [tumor necrosis factor (TNF)-alpha] and nerve growth factor (NGF) levels in the SC ( each of which is a known NF-kappaB activator ) , we redetermined NF-kappaB levels in the SCs and livers of TGX rats treated with anti-TNF-alpha or anti-NGF antibodies and found that NF-kappaB levels normalized in both tissues after either treatment . Negative_regulation TNF CBS 20050288 2177397 We observed that *inhibited* the LPS induced release of interleukin-1 beta and [tumor necrosis factor-alpha] from microglia . Negative_regulation TNF CCK 11819851 892891 In the heart , significantly *inhibited* LPS induced increase of [TNF-alpha] ( 864 +/- 123 ng . Negative_regulation TNF CCK 11833090 910236 *inhibits* expression of [TNF-alpha] in the spleen of endotoxic shock rats and signal transduction mechanism of p38 MAPK . Negative_regulation TNF CCK 22357963 2572182 Furthermore , *inhibited* both expression of [tumor necrosis factor-a] and chemotaxis in cultured THP-1 cells . Negative_regulation TNF CCK 24301797 2910662 *inhibited* TLR9 induced activation of [tumor-necrosis factor] receptor associated factor 6 , which is an important adapter protein in activation of interferon-regulatory factor (IRF)5 and IRF7 , possibly through CCK2R , by evoking the activity of protein kinase (PK)A and reducing the activity of PKC . Negative_regulation TNF CCL19 21593384 2441507 With regard to pDCs , Notch activation *induced* [TNF-a] whereas Notch inhibition significantly abrogated the secretion of , CXCL9 , CXCL10 , and TNF-a . Negative_regulation TNF CCL2 10716998 676632 We have shown previously that in human monocytes , bacterial lipopolysaccharide , IL-1 , and [tumor necrosis factor-alpha] *induce* a rapid down-regulation of the receptor CCR2 ( CC chemokine receptor-2 ) . Negative_regulation TNF CCL2 7523503 272211 IL-1 and [TNF-alpha] stimulation also can *induce* low levels of production . Negative_regulation TNF CCL20 23601903 2804401 Inhibition of *increased* serum [tumor necrosis factor (TNF)-a] ( 3.3-fold greater than control mice ) and decreased serum interleukin (IL)-1a and IL-6 . Negative_regulation TNF CCL21 10426368 632916 Accordingly , from hIL-13 treated mice secreted less interferon (IFN)-gamma upon ex vivo stimulation with Concanavalin A than controls , and anti-CD3 monoclonal antibody induced activation of T-cells in vivo *resulted* in lower blood levels of IFN-gamma and [tumor necrosis factor-alpha] and augmented blood levels of IL-4 in NOD mice pretreated with hIL-13 . Negative_regulation TNF CCL28 17986783 1826788 We found that *suppressed* pollen induced [TNF-alpha] release and increased IFN-gamma release from PBMCs . Negative_regulation TNF CCR2 15517610 1343154 Inhibition of directly augmented Toll-like receptor *induced* IL-10 , but not [TNF] and IL-6 , production of macrophages in vitro . Negative_regulation TNF CCR6 11090084 754444 Among recombinant cytokines , [TNF-alpha] *induced* high levels of mRNA expression , whereas interferon (IFN)-gamma induced low levels . Negative_regulation TNF CD14 10657659 664132 In contrast to this , *blocked* LPS induced [TNF] production from monocytes , whereas anti-TLR2 showed no inhibition . Negative_regulation TNF CD14 15760549 1383238 Glycine could efficiently protect rat liver grafts from ischemia-reperfusion injury by repressing the expression of and NF-kappa B binding activity in Kupffer cells and *inhibiting* the productions of [TNF alpha] and IL-1 . Negative_regulation TNF CD14 20419140 2246656 Strikingly , neutrophil influx and [TNF] release induced by high dose S-LPS or R-LPS was diminished in the *presence* of . Negative_regulation TNF CD14 7515917 257364 Recombinant soluble *inhibits* LPS induced [tumor necrosis factor-alpha] production by cells in whole blood . Negative_regulation TNF CD14 7528733 291386 Anti-CD14 monoclonal antibodies MY4 and 3C10 inhibited LPS binding protein and dependent activation of TNF-alpha production by LPS at LPS concentrations up to approximately 1.0 ng/ml. R-HDL ( 2 mg of protein per ml ) *blocked* [TNF-alpha] production by LPS from both smooth- and rough-type gram negative bacteria at concentrations up to 100 ng of LPS per ml but had little effect on heat killed gram positive Staphylococcus aureus and no effect on other LPS independent stimuli tested . Negative_regulation TNF CD14 7529289 291442 Activation of human monocytes by streptococcal rhamnose glucose polymers is mediated by , and mannan binding protein *inhibits* [TNF-alpha] release . Negative_regulation TNF CD14 7536782 300305 Our results also suggest that , in P-PEM , in contrast to J774.1 cells and T-PEM , neither PKC nor is *involved* in the LPS induced activation and suppression of [TNF-alpha] gene expression . Negative_regulation TNF CD14 8614033 353585 The inhibition *resulted* in a 55 % reduction in baseline [TNF] activity . Negative_regulation TNF CD19 11120817 758237 Interestingly , early [TNF-alpha] release is also *impaired* in Cr2 ( null ) and ( null ) animals , suggesting that these molecules directly affect mast cell activation . Negative_regulation TNF CD19 23427243 2744210 In healthy individuals , ( + ) CD24 ( hi ) CD38 ( hi ) B cells *suppress* CD4 ( + ) CD25 ( - ) T cell proliferation as well as the release of interferon-? and [tumor necrosis factor-a] by these cells ; Negative_regulation TNF CD1A 7536438 297249 [TNF-alpha] *induced* a dose- and time dependent decrease in epidermal Langerhans cell numbers and an increase in dermal CD1a+ cells , suggesting migration of Langerhans cells away from the epidermis . Negative_regulation TNF CD200 18946351 1978812 In addition , a soluble form of , prepared by fusing the extracellular domain of the truncated CD200 to a murine IgG2a Fc region , could *block* in a competitive fashion the CD200Fc mediated suppression of cytotoxic T lymphocyte induced in mixed leukocyte reactions , of [tumor necrosis factor-alpha] produced by lipopolysaccharide stimulated splenic cells , and of allogeneic skin graft rejection in vivo . Negative_regulation TNF CD200 20442224 2294131 Suppression of functional expression of *augmented* killing of the CD200+ cells , as well as production of the inflammatory cytokines IFN-gamma and [TNF-alpha] by effector PBMCs . Negative_regulation TNF CD200R1 24388216 2900144 signaling *inhibits* the expression of proinflammatory molecules including [tumor necrosis factor] , interferons , and inducible nitric oxide synthase in response to selected stimuli . Negative_regulation TNF CD24 23881416 2909373 Meanwhile , downregulation of significantly *induced* an increase of NF-?B DNA binding activity and mRNA levels of [TNF-a] and IL-1ß . Negative_regulation TNF CD27 23189166 2704801 Additionally , we found that CD19 ( + ) CD24 ( hi ) ( + ) B cells from healthy individuals *inhibited* proliferation and [TNF-a] production of CD4 ( + ) T cells via an IL-10 independent pathway . Negative_regulation TNF CD274 19729380 2163105 blockade on DSCs strongly *enhanced* T cell cytokine production ( IFN-gamma , [TNF-alpha] and IL-2 ) , whereas B7-DC blockade had similar but more modest effects . Negative_regulation TNF CD274 20815020 2324960 These findings were confirmed in T cell-macrophage in vitro coculture in which *diminished* [tumor necrosis factor-a/IL-6] levels in an IL-10 dependent manner . Negative_regulation TNF CD274 21540239 2449222 In autologous cultures of primary ALCL and DLBCL , blockade *enhanced* secretion of inflammatory cytokines IFN-? , granulocyte macrophage colony stimulating factor , interleukin (IL)-1 , IL-6 , IL-8 , IL-13 , [TNF-a] , and macrophage inflammatory protein-1a . Negative_regulation TNF CD28 16434693 1540475 However , compared with stimulation with phorbol 12-myristate 13-acetate plus ionomycin , jacalin plus *resulted* in decreased levels of [tumor necrosis factor] alpha secretion . Negative_regulation TNF CD28 9058822 417711 Anti-IL-10 Ab could also suppress the Ab-induced *inhibition* of [TNF-alpha] production , either in vivo or in vitro . Negative_regulation TNF CD300A 18535206 1945568 triggering by cross linking antibody *reduced* [TNF-alpha] and increased IFN-alpha secretion by pDCs . Negative_regulation TNF CD300A 18535206 1945569 Furthermore , triggering , in the presence of neutralizing IFN-alpha , further *reduced* [TNF-alpha] secretion . Negative_regulation TNF CD34 12067408 955012 expression was gradually lost , so that by day 9 , the majority of the cells were CD34 ( - ) /CMRF-44 ( + ) . GM-CSF and [TNF-alpha] also *induced* CD40 expression , and up-regulation of CD54 and MHC class II on CD34 ( + ) cells ; Negative_regulation TNF CD36 11359831 816389 Furthermore , we show that proliferator activated receptor gamma-retinoid X receptor agonists induce an increase in *mediated* phagocytosis and a decrease in parasite induced [TNF-alpha] secretion . Negative_regulation TNF CD36 19593846 2105350 Quantitative real-time PCR assays showed that CE treatment decreased the mRNA expression of IL-1beta , IL-6 and [TNF-alpha] , improved the mRNA expression of IR , IRS1 , IRS2 , PI3K and Akt1 , *inhibited* , MTTP , and PTEN , and enhanced the impaired SREBP-1c expression in TNF-alpha treated enterocytes . Negative_regulation TNF CD36 7553223 323266 Removal of HLA-DR+ or monocytes also caused a significant reduction in S-27609- and imiquimod *induced* IFN-alpha and [TNF] . Negative_regulation TNF CD3EAP 23986533 2841385 Mechanistic investigations using small interfering RNA and KO bone marrow to generate CAST-deficient macrophages showed that deficiency during activation with bacterial pathogen associated molecular patterns , including heat killed Enterococcus faecalis or CpG DNA , *led* to increased I?B cleavage , NF-?B nuclear localization , and IL-6 and [TNF-a] secretion . Negative_regulation TNF CD4 10047431 592434 Depletion of either ( + ) or CD8 ( + ) T cells may prevent beta-cell destruction by decreasing IFN-gamma and IL-10 production in islets and *increasing* IL-4 and [TNF-alpha] production systemically . Negative_regulation TNF CD4 1548758 183842 Soluble recombinant did not *block* [TNF alpha] and IL-1 production . Negative_regulation TNF CD4 19595251 2105473 The level of [TNFalpha] decreased , and the numbers of CD ( 3 ) ( + ) and ( + ) T lymphocytes *increased* significantly on day 4 in Combined Therapy Group ( P < 0.05 or P < 0.01 ) . Negative_regulation TNF CD4 23105565 1671712 Despite the rising IL-10 mRNA levels , [TNF-a] mRNA levels *increased* with severity of HIV and decrease in ( + ) T cell counts . Negative_regulation TNF CD4 7522637 272104 In addition , *resulted* in the induction of interferon-gamma (IFN-gamma) and [tumor necrosis factor-alpha (TNF-alpha)] in the absence of interleukin-2 (IL-2) and IL-4 secretion in PBMCs . Negative_regulation TNF CD4 7572384 328891 in PBMC also *resulted* in induction of the cytokines INF-tau and [TNF-alpha] in the absence of IL-2 and IL-4 secretion . Negative_regulation TNF CD40 10332965 614902 IL-10 exerted inhibitory effects on both ligation induced and CD40 ligation plus IFN-gamma *induced* [TNF-alpha] production by ST cells . Negative_regulation TNF CD40 10352303 617270 while and CTLA-4-Fc *reduced* IL-10 and [TNF-alpha] levels , anti-CD23 did not affect TNF-alpha while attenuating IL-10 generation . Negative_regulation TNF CD40 15378516 1298111 Furthermore , lovastatin is able to suppress microglial [tumor necrosis factor-alpha] , interleukin (IL)-beta1 and IL-6 production promoted either by IFN-gamma or by Abeta peptide challenge in the *presence* of cross linking . Negative_regulation TNF CD40 16343349 1493984 Further , this stimulation was also able to suppress microglial [TNF-alpha] and nitric oxide production induced either by IFN-gamma or Abeta peptide challenge in the *presence* of ligation . Negative_regulation TNF CD40 18949670 1982405 Here , we demonstrate for the first time a significantly lower baseline expression and *induced* modulation capacity of [TNF] receptor and costimulatory molecules in pediatric proB-ALL compared to more mature precursor B-ALL blasts . Negative_regulation TNF CD40 22956783 2684018 Abundance of miR-181a attenuated ox-LDL induced CD83 and expression , *inhibited* the secretion of interleukin (IL)-6 and [TNF-a] , and up-regulated IL-10 , an important anti-inflammatory cytokine that was inhibited by ox-LDL . Negative_regulation TNF CD40 7535097 287771 Induction of TNF-alpha mRNA was inhibited by actinomycin D suggesting that ligation *results* in transcriptional activation of the [TNF-alpha] and LT-alpha genes . Negative_regulation TNF CD40 8977185 408675 Using CD40-ligand transfected L cells (CD40Lc) , we demonstrated that triggering *results* in an enhanced secretion of both IL-8 and [TNF-alpha] by cultured epidermal basal cells , suggesting that CD40-CD40L interactions may play a role in amplifying the cutaneous inflammatory reactions . Negative_regulation TNF CD44 14729358 1198380 In the primary cultured cells , [TNFalpha] *induced* an important upregulation of ICAM-1 , Fas and CD40 whereas and CD63 were significantly decreased . Negative_regulation TNF CD44 7508890 244848 However , and anti-HLA-DR MAbs effectively *blocked* TNF release and [TNF-mRNA] induction in monocytes . Negative_regulation TNF CD47 18809435 1981285 Both mAbs to SHPS-1 , but not that to , also *inhibited* the lipopolysaccharide- or polyinosinic-polycytidylic acid induced production of [TNF-alpha] by DCs . Negative_regulation TNF CD47 20844955 2401451 whole-blood stimulation with LPS and Pam-3-Cys *resulted* in increased IL-6 and [tumor necrosis factor (TNF)-alpha] secretion compared with WT . Negative_regulation TNF CD63 14729358 1198381 In the primary cultured cells , [TNFalpha] *induced* an important upregulation of ICAM-1 , Fas and CD40 whereas CD44 and were significantly decreased . Negative_regulation TNF CD79A 8262556 239178 The presence of containing immune complexes in monocyte monolayers *resulted* in a dose dependent increase of [TNF] production . Negative_regulation TNF CD80 23000301 2694265 We found that Tregs derived from the tumor mice down-regulated the expression of costimulatory molecules on DCs and *inhibited* the production of [TNF-a] and IL-12 from DCs . Negative_regulation TNF CD83 22956783 2684019 Abundance of miR-181a attenuated ox-LDL induced and CD40 expression , *inhibited* the secretion of interleukin (IL)-6 and [TNF-a] , and up-regulated IL-10 , an important anti-inflammatory cytokine that was inhibited by ox-LDL . Negative_regulation TNF CD86 23000301 2694266 We found that Tregs derived from the tumor mice down-regulated the expression of costimulatory molecules on DCs and *inhibited* the production of [TNF-a] and IL-12 from DCs . Negative_regulation TNF CD8A 10047431 592435 Depletion of either CD4 ( + ) or ( + ) T cells may prevent beta-cell destruction by decreasing IFN-gamma and IL-10 production in islets and *increasing* IL-4 and [TNF-alpha] production systemically . Negative_regulation TNF CD8A 20883666 2343142 Mechanically , the in vitro co-culture assay revealed that both CD4 ( + ) T and ( + ) T cells , as well as regulatory T cells , could *inhibit* [TNF-a] secretion by monocytes . Negative_regulation TNF CD8B 10047431 592436 Depletion of either CD4 ( + ) or ( + ) T cells may prevent beta-cell destruction by decreasing IFN-gamma and IL-10 production in islets and *increasing* IL-4 and [TNF-alpha] production systemically . Negative_regulation TNF CD8B 20883666 2343143 Mechanically , the in vitro co-culture assay revealed that both CD4 ( + ) T and ( + ) T cells , as well as regulatory T cells , could *inhibit* [TNF-a] secretion by monocytes . Negative_regulation TNF CDC73 1873355 165230 Further , the *role* of released in response to a challenge with LPS in the regulation of [TNF] and IL-6 production was investigated . Negative_regulation TNF CDC73 8514698 221945 Repeated dosing also *resulted* in sustained increased serum [tumor necrosis factor-alpha] levels ( 1,610 +/- 470 pg/ml , P < 0.01 ) and further exacerbation of the leukopenia ( -68 +/- 6 % , P < 0.01 ) and thrombocytopenia ( -65 +/- 8 % , P < 0.01 ) . Negative_regulation TNF CDC73 9403541 469603 Furthermore , inhibiting production with AACOCF3 , or manoalide , also *inhibited* LPS induced Mphi [TNF] mRNA expression . Negative_regulation TNF CDH1 12503700 1026841 In human bronchial epithelial cells the authors have shown that [tumour necrosis factor (TNF)-alpha] *induced* a significant decrease of and beta-catenin expression . Negative_regulation TNF CDH13 19531803 2098812 Suppression of LPS induced [TNF-alpha] production in macrophages by cAMP is *mediated* by . Negative_regulation TNF CDH5 12010652 941259 Our results indicate that [TNF-alpha] affects VE-cadherin gene expression on the transcriptional level , *inducing* a downregulation of the expression . Negative_regulation TNF CDK9 9485206 488252 We show here that engagement of the CD94-NKG2A *inhibits* both antigen-driven [tumor necrosis factor (TNF)] release and cytotoxicity on melanoma-specific human T cell clones . Negative_regulation TNF CDKN1A 14599803 1161371 We found that the histone deacetylase (HDAC) inhibitors ( phenylbutyrate and trichostatin A ) causing histone hyperacetylation to modulate multiple gene expression not only induced the expression of ( Cip1 ) and p16(INK4) in synovial cells but also *inhibited* the expression of [tumor necrosis factor-alpha] in affected tissues in adjuvant arthritis , an animal model of RA . Negative_regulation TNF CDKN2A 14599803 1161372 We found that the histone deacetylase (HDAC) inhibitors ( phenylbutyrate and trichostatin A ) causing histone hyperacetylation to modulate multiple gene expression not only induced the expression of p21 ( Cip1 ) and in synovial cells but also *inhibited* the expression of [tumor necrosis factor-alpha] in affected tissues in adjuvant arthritis , an animal model of RA . Negative_regulation TNF CEBPA 11456275 838124 In fully differentiated adipocytes , [TNF-alpha] rapidly *induced* C/EBPbeta and C/EBPdelta , whereas it downregulated the expression of and PPARgamma . Negative_regulation TNF CEBPA 20444945 2275060 Dominant negative and cAMP response element binding protein or short interfering RNA of C/EBPbeta *blocked* [TNF-] or cAMP induced SAA3 promoter activity . Negative_regulation TNF CEBPB 12871593 1114131 *Activation* of NF-kappaB as well as by p40 and inhibition of p40 induced expression of [TNF-alpha] by Deltap65 , a dominant negative mutant of p65 , and DeltaC/EBPbeta , a dominant negative mutant of C/EBPbeta , suggests that p40 induces the expression of TNF-alpha through the activation of NF-kappaB and C/EBPbeta . Negative_regulation TNF CEL 15668324 1395365 In serum containing conditions , N-EL had no effect , whereas both and FL-EL *inhibited* [TNF-alpha] production . Negative_regulation TNF CEP104 15748162 1379340 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP104 15904918 1411785 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP104 15904918 1411839 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP104 15904918 1411866 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP104 21856446 2496072 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP104 24045962 2902254 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP104 24062060 2920886 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP112 15748162 1379352 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP112 15904918 1411797 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP112 15904918 1411851 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP112 15904918 1411878 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP112 21856446 2496084 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP112 24045962 2902266 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP112 24062060 2920898 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP120 15748162 1379350 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP120 15904918 1411795 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP120 15904918 1411849 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP120 15904918 1411876 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP120 21856446 2496082 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP120 24045962 2902264 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP120 24062060 2920896 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP128 15748162 1379338 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP128 15904918 1411783 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP128 15904918 1411837 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP128 15904918 1411864 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP128 21856446 2496070 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP128 24045962 2902252 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP128 24062060 2920884 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP135 15748162 1379356 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP135 15904918 1411801 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP135 15904918 1411855 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP135 15904918 1411882 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP135 21856446 2496088 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP135 24045962 2902270 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP135 24062060 2920902 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP152 15748162 1379358 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP152 15904918 1411803 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP152 15904918 1411857 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP152 15904918 1411884 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP152 21856446 2496090 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP152 24045962 2902272 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP152 24062060 2920904 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP164 15748162 1379357 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP164 15904918 1411802 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP164 15904918 1411856 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP164 15904918 1411883 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP164 21856446 2496089 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP164 24045962 2902271 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP164 24062060 2920903 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP170 15748162 1379353 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP170 15904918 1411798 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP170 15904918 1411852 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP170 15904918 1411879 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP170 21856446 2496085 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP170 24045962 2902267 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP170 24062060 2920899 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP19 15748162 1379351 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP19 15904918 1411796 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP19 15904918 1411850 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP19 15904918 1411877 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP19 21856446 2496083 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP19 24045962 2902265 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP19 24062060 2920897 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP192 15748162 1379343 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP192 15904918 1411788 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP192 15904918 1411842 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP192 15904918 1411869 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP192 21856446 2496075 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP192 24045962 2902257 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP192 24062060 2920889 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP250 15748162 1379337 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP250 15904918 1411782 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP250 15904918 1411836 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP250 15904918 1411863 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP250 21856446 2496069 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP250 24045962 2902251 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP250 24062060 2920883 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP290 15748162 1379354 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP290 15904918 1411799 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP290 15904918 1411853 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP290 15904918 1411880 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP290 21856446 2496086 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP290 24045962 2902268 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP290 24062060 2920900 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP350 15748162 1379339 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP350 15904918 1411784 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP350 15904918 1411838 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP350 15904918 1411865 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP350 21856446 2496071 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP350 24045962 2902253 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP350 24062060 2920885 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP41 15748162 1379336 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP41 15904918 1411781 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP41 15904918 1411835 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP41 15904918 1411862 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP41 21856446 2496068 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP41 24045962 2902250 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP41 24062060 2920882 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP44 15748162 1379359 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP44 15904918 1411804 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP44 15904918 1411858 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP44 15904918 1411885 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP44 21856446 2496091 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP44 24045962 2902273 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP44 24062060 2920905 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP55 15748162 1379335 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP55 15904918 1411780 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP55 15904918 1411834 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP55 15904918 1411861 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP55 21856446 2496067 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP55 24045962 2902249 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP55 24062060 2920881 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP57 15748162 1379361 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP57 15904918 1411806 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP57 15904918 1411860 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP57 15904918 1411887 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP57 21856446 2496093 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP57 24045962 2902275 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP57 24062060 2920907 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP63 15748162 1379347 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP63 15904918 1411792 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP63 15904918 1411846 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP63 15904918 1411873 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP63 21856446 2496079 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP63 24045962 2902261 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP63 24062060 2920893 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP68 15748162 1379355 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP68 15904918 1411800 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP68 15904918 1411854 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP68 15904918 1411881 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP68 21856446 2496087 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP68 24045962 2902269 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP68 24062060 2920901 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP70 15748162 1379360 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP70 15904918 1411805 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP70 15904918 1411859 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP70 15904918 1411886 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP70 21856446 2496092 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP70 24045962 2902274 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP70 24062060 2920906 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP72 15748162 1379344 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP72 15904918 1411789 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP72 15904918 1411843 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP72 15904918 1411870 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP72 21856446 2496076 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP72 24045962 2902258 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP72 24062060 2920890 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP76 15748162 1379345 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP76 15904918 1411790 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP76 15904918 1411844 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP76 15904918 1411871 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP76 21856446 2496077 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP76 24045962 2902259 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP76 24062060 2920891 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP78 15748162 1379346 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP78 15904918 1411791 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP78 15904918 1411845 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP78 15904918 1411872 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP78 21856446 2496078 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP78 24045962 2902260 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP78 24062060 2920892 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP85 15748162 1379342 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP85 15904918 1411787 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP85 15904918 1411841 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP85 15904918 1411868 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP85 21856446 2496074 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP85 24045962 2902256 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP85 24062060 2920888 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP89 15748162 1379348 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP89 15904918 1411793 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP89 15904918 1411847 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP89 15904918 1411874 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP89 21856446 2496080 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP89 24045962 2902262 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP89 24062060 2920894 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP95 15748162 1379341 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP95 15904918 1411786 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP95 15904918 1411840 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP95 15904918 1411867 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP95 21856446 2496073 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP95 24045962 2902255 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP95 24062060 2920887 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CEP97 15748162 1379349 Moreover , *inhibited* brain [TNF] production induced by intracerebroventricular injection of lipopolysaccharide in mice . Negative_regulation TNF CEP97 15904918 1411794 , an inhibitor of the SAPK/JNK pathway , *reduces* [TNF-alpha] release from lipopolysaccharide treated cells and mice . Negative_regulation TNF CEP97 15904918 1411848 also *inhibited* [TNF-alpha] production in lipopolysaccharide stimulated microglial cells , but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR ) . Negative_regulation TNF CEP97 15904918 1411875 significantly *inhibited* [TNF-alpha] production at doses of 1-10 mg/kg as measured by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF CEP97 21856446 2496081 In addition , could *reduce* the production of interleukin-6 and [tumor necrosis factor-a] in LPS stimulated DCs . Negative_regulation TNF CEP97 24045962 2902263 dose-dependently *inhibited* the release of [TNF-a] , IL-6 , and IL-1ß in LPS stimulated RAW264.7 cells . Negative_regulation TNF CEP97 24062060 2920895 The results show that significantly attenuates the infiltration of neutrophils , suppresses myeloperoxidase activity , and *reduces* the levels of [TNF-a] , IL-1ß , and IL-6 in LPS induced mouse mastitis . Negative_regulation TNF CFP 11546973 856656 the presence of either *attenuated* [tumor necrosis factor-alpha] production after lipopolysaccharide stimulation . Negative_regulation TNF CFP 16857767 1600439 are beneficial in animals with bacterial pneumonia and *reduce* production of [TNF-alpha] . Negative_regulation TNF CGA 20620227 2304104 Moreover , dose-dependently *reduced* histamine and [TNF-alpha] release from RBL-2H3 cells activated by anti-DNP IgE . Negative_regulation TNF CGA 20637839 2322024 significantly *reduced* pulmonary eosinophilia and expression of IL-4 , IL-5 and [TNF-a] in the lung as well as the serum levels of total and OVA-specific IgE , while CGA enhanced those of total and OVA-specific IgG3 , of which isotype switching is down-regulated by IL-4 . Negative_regulation TNF CGA 22580132 2614256 Our data demonstrated that significantly *suppressed* NO production and [TNF-a] release in LPS stimulated primary microglia . Negative_regulation TNF CHGA 19155580 2006920 Dietary significantly *inhibited* the elevated production of [TNF] by lipopolysaccharide stimulated macrophages in nephritic and hepatoma bearing rats compared with dietary casein , while it exerted no influence on the TNF productivity in normal rats . Negative_regulation TNF CHGA 21462331 2412861 This study also showed that tumor necrosis factor a (TNF-a) induced mRNA expression in HT-29 human colon cancer cells , and vitamin B6 ( pyridoxal hydrochloride ) pretreatment of HT-29 cells *inhibited* [TNF] -induced mRNA expression of SPI-3 . Negative_regulation TNF CHP1 23261362 2745770 In addition , significantly *attenuated* LPS induced [TNF-a] , IL-1ß and IL-6 production . Negative_regulation TNF CHP2 23261362 2745771 In addition , significantly *attenuated* LPS induced [TNF-a] , IL-1ß and IL-6 production . Negative_regulation TNF CHRFAM7A 8373268 229672 MAb <3D10> , an IgM also directed against the O-antigen polysaccharide region of E. coli 0111 : B4 LPS , *inhibited* [TNF-alpha] secretion but did not increase cellular uptake of LPS , presumably acting solely due to LPS neutralization . Negative_regulation TNF CHUK 11124824 768954 We analyzed the differential *role* of and I kappa B kinase 2 (IKK2) in [tumor necrosis factor alpha (TNF-alpha)-] and interleukin-1 beta (IL-1 beta) mediated NF-kappa B activation in primary rat hepatocytes . Negative_regulation TNF CHUK 11179444 784691 [TNF-alpha-] or C2-ceramide induced COX-2 promoter activity was *inhibited* by the dominant negative mutant of extracellular signal regulated kinase 2 , p38 , JNK , , or IKK2 . Negative_regulation TNF CHUK 12847684 1109011 To investigate the potential *role* of and IKK-2 in the regulation of nuclear factor kappaB (NF-kappaB) activation and the expression of [tumor necrosis factor alpha (TNFalpha)] , as well as interleukin-1beta (IL-1beta) , IL-6 , IL-8 , vascular endothelial growth factor ( VEGF ) , and matrix metalloproteinases ( MMPs ) , in rheumatoid arthritis ( RA ) . Negative_regulation TNF CHUK 16774932 1672067 PMA selectively causes the degradation of IkappaB kinases ( IKKs ) including IKK-gamma and IKK-beta , and subsequent inhibition of [tumor necrosis factor (TNF)] *induced* and NF-kappaB activation in human colon cancer cell line HCT-116 , but not in other gastrointestinal tract cells . Negative_regulation TNF CHUK 20304950 2254849 Also , reduction of levels in keratinocytes *up-regulated* the expression of monocyte chemoattractant protein-1 ( MCP-1/CCL2 ) , [TNFalpha] , IL-1 , and IL-6 , and elevated macrophage migration , which might promote macrophage recruitment and inflammation . Negative_regulation TNF CIDEA 15919794 1413475 Human adipocyte depletion of by RNA interference stimulated lipolysis and *increased* [TNF-alpha] secretion by a posttranscriptional effect . Negative_regulation TNF CISH 16303184 1502917 In LPS stimulated astrocytes , <9-cis-RA> *inhibited* NO and [TNF-alpha] production but had not effect on IL-1beta , IL-6 and MCP-1 secretion . Negative_regulation TNF CISH 7818524 292873 We present evidence that both the and trans- forms of RA and to a lesser extent , the RA precursor beta-carotene , can *inhibit* recombinant human [TNF] cytolytic activity in mouse L-929 cells . Negative_regulation TNF CLDN1 23538493 2788575 In addition , [TNF-a] *induced* a downregulation of , claudin-2 , claudin-4 , and occludin as well as activation of phosphatidylinositol 3-kinase signaling in T-84 but not Caco-2 cells , which was reversed by adalimumab . Negative_regulation TNF CLDN4 23538493 2788576 In addition , [TNF-a] *induced* a downregulation of claudin-1 , claudin-2 , , and occludin as well as activation of phosphatidylinositol 3-kinase signaling in T-84 but not Caco-2 cells , which was reversed by adalimumab . Negative_regulation TNF CLEC7A 16985290 1617616 Blocking significantly *inhibited* the induction of [TNF-alpha] and IL-12p70 production by SCG . Negative_regulation TNF CLEC7A 18279049 1896359 Silencing of *resulted* in reduced expression of proinflammatory cytokines ( [tumor necrosis factor-alpha] and interleukin-12 ) , which was also reduced by anti-Dectin-1 antibody treatment prior to exposure to A. fumigatus , zymosan , or Candida albicans . Negative_regulation TNF CLEC7A 18729738 1956277 Blocking significantly *inhibited* the induction of [TNF-alpha] production by SCG . Negative_regulation TNF CLU 17359935 1712668 Presence of *reduced* NF-kappaB activation and expression of the NF-kappaB target genes [TNF-alpha] and MOB-1 under cell stress . Negative_regulation TNF CNP 19217919 2086508 We have previously shown that *inhibits* both basal and [TNFalpha] induced expression of PAI-1 in human endothelial cells . Negative_regulation TNF CNR1 18393970 1958042 Furthermore , the selective cannabinoid and CB2 receptor antagonists , AM251 and AM630 respectively , and the transient receptor potential vanilloid receptor-1 ( TRPV1 ) antagonist , SB366791 , *reduced* LPS induced [TNF-alpha] plasma levels both alone and in combination with AM404 . Negative_regulation TNF CNR2 19115380 2099862 We further showed that the activation of receptors significantly *reduced* the levels of [tumor necrosis factor-alpha (TNF-alpha)] that had been increased by the lesion with malonate . Negative_regulation TNF CNTF 18214991 1895507 We show that *reduces* COX-2 levels , whereas IL-6 increases the expression of IL-1beta , [TNFalpha] , and Cox-2 . Negative_regulation TNF CNTF 8529123 336683 , administered either alone or in combination with its soluble receptor , *inhibited* the induction of serum [TNF] levels by LPS . Negative_regulation TNF CNTF 9650821 478469 Since *inhibits* the production of [TNF] and activates the hypothalamus-pituitary-adrenal axis ( HPAA ) , we investigated whether CNTF can produce antiinflammatory actions and whether it may act through a central mechanism , using the murine air pouch model of inflammation . Negative_regulation TNF CNTN2 17314097 1719492 Interestingly , peptides spanning CCR2 and/or LZ disrupt and IKKgamma-PP2A interactions and potently *inhibit* NF-kappaB activation by Tax and [tumor necrosis factor-alpha] . Negative_regulation TNF COQ2 19096114 2003936 In the *presence* of 2.5 microM or 75 microM the LPS induced [TNF-alpha] response was significantly reduced to 73.3 +/- 2.8 % and 74.7 +/- 8.9 % in apoE3 or apoE4 cells , respectively . Negative_regulation TNF COQ2 21262220 2398082 significantly suppressed lipid peroxidation , restored the depleted antioxidant defenses , and *attenuated* the increases of [tumor necrosis factor-a] and nitric oxide resulted from arsenic administration . Negative_regulation TNF COQ2 21990004 2674584 Data obtained also indicate that ( 10 ) *prevents* over-expression of [TNF-a] after exercise , together with an increase in sTNF-RII that limits the pro-inflammatory actions of TNF . Negative_regulation TNF COQ3 19096114 2003932 In the *presence* of 2.5 microM or 75 microM the LPS induced [TNF-alpha] response was significantly reduced to 73.3 +/- 2.8 % and 74.7 +/- 8.9 % in apoE3 or apoE4 cells , respectively . Negative_regulation TNF COQ3 21262220 2398078 significantly suppressed lipid peroxidation , restored the depleted antioxidant defenses , and *attenuated* the increases of [tumor necrosis factor-a] and nitric oxide resulted from arsenic administration . Negative_regulation TNF COQ3 21990004 2674580 Data obtained also indicate that ( 10 ) *prevents* over-expression of [TNF-a] after exercise , together with an increase in sTNF-RII that limits the pro-inflammatory actions of TNF . Negative_regulation TNF COQ4 19096114 2003933 In the presence of 2.5 microM or 75 microM the LPS induced [TNF-alpha] response was significantly *reduced* to 73.3 +/- 2.8 % and 74.7 +/- 8.9 % in apoE3 or apoE4 cells , respectively . Negative_regulation TNF COQ4 21262220 2398079 significantly suppressed lipid peroxidation , restored the depleted antioxidant defenses , and *attenuated* the increases of [tumor necrosis factor-a] and nitric oxide resulted from arsenic administration . Negative_regulation TNF COQ4 21990004 2674581 Data obtained also indicate that ( 10 ) *prevents* over-expression of [TNF-a] after exercise , together with an increase in sTNF-RII that limits the pro-inflammatory actions of TNF . Negative_regulation TNF COQ5 19096114 2003938 In the *presence* of 2.5 microM or 75 microM the LPS induced [TNF-alpha] response was significantly reduced to 73.3 +/- 2.8 % and 74.7 +/- 8.9 % in apoE3 or apoE4 cells , respectively . Negative_regulation TNF COQ5 21262220 2398084 significantly suppressed lipid peroxidation , restored the depleted antioxidant defenses , and *attenuated* the increases of [tumor necrosis factor-a] and nitric oxide resulted from arsenic administration . Negative_regulation TNF COQ5 21990004 2674586 Data obtained also indicate that ( 10 ) *prevents* over-expression of [TNF-a] after exercise , together with an increase in sTNF-RII that limits the pro-inflammatory actions of TNF . Negative_regulation TNF COQ6 19096114 2003934 In the *presence* of 2.5 microM or 75 microM the LPS induced [TNF-alpha] response was significantly reduced to 73.3 +/- 2.8 % and 74.7 +/- 8.9 % in apoE3 or apoE4 cells , respectively . Negative_regulation TNF COQ6 21262220 2398080 significantly suppressed lipid peroxidation , restored the depleted antioxidant defenses , and *attenuated* the increases of [tumor necrosis factor-a] and nitric oxide resulted from arsenic administration . Negative_regulation TNF COQ6 21990004 2674582 Data obtained also indicate that ( 10 ) *prevents* over-expression of [TNF-a] after exercise , together with an increase in sTNF-RII that limits the pro-inflammatory actions of TNF . Negative_regulation TNF COQ7 19096114 2003935 In the presence of 2.5 microM or 75 microM the LPS induced [TNF-alpha] response was significantly *reduced* to 73.3 +/- 2.8 % and 74.7 +/- 8.9 % in apoE3 or apoE4 cells , respectively . Negative_regulation TNF COQ7 21262220 2398081 significantly suppressed lipid peroxidation , restored the depleted antioxidant defenses , and *attenuated* the increases of [tumor necrosis factor-a] and nitric oxide resulted from arsenic administration . Negative_regulation TNF COQ7 21990004 2674583 Data obtained also indicate that ( 10 ) *prevents* over-expression of [TNF-a] after exercise , together with an increase in sTNF-RII that limits the pro-inflammatory actions of TNF . Negative_regulation TNF COQ9 19096114 2003937 In the presence of 2.5 microM or 75 microM the LPS induced [TNF-alpha] response was significantly *reduced* to 73.3 +/- 2.8 % and 74.7 +/- 8.9 % in apoE3 or apoE4 cells , respectively . Negative_regulation TNF COQ9 21262220 2398083 significantly suppressed lipid peroxidation , restored the depleted antioxidant defenses , and *attenuated* the increases of [tumor necrosis factor-a] and nitric oxide resulted from arsenic administration . Negative_regulation TNF COQ9 21990004 2674585 Data obtained also indicate that ( 10 ) *prevents* over-expression of [TNF-a] after exercise , together with an increase in sTNF-RII that limits the pro-inflammatory actions of TNF . Negative_regulation TNF CORT 24035860 2862551 The results showed that Rg1 or could *reduce* the production of NO and [TNF-a] , and Rg1 dose-dependently up-regulated GR expression , while Cort dose-dependently down-regulated GR expression . Negative_regulation TNF CPB1 19923057 2166979 *resulted* in increased [TNF-alpha] and IL-1beta production in the lung tissues . Negative_regulation TNF CPB2 19923057 2166980 *resulted* in increased [TNF-alpha] and IL-1beta production in the lung tissues . Negative_regulation TNF CPOX 12943802 1135748 Since cyclooxygenase , COX , is the rate controlling enzyme in PGE production , inhibitors , otherwise known as non-steroidal anti-inflammatory drugs ( NSAID ) , *increase* [TNF] synthesis and release by depriving AC of PGE . Negative_regulation TNF CPOX 12943802 1135749 This paper reviews the data on [TNF] *up-regulation* by tenofovir and inhibitors and the consequent augmented antigen driven lymphocyte proliferation secondary to increased TNF and suggests exploration of tenofovir and COX inhibitors like indomethacin , diclofenac or ketorolac in augmentation of current cancer immunotherapy attempts . Negative_regulation TNF CPOX 16518767 1531091 [Tumor necrosis factor (TNF)-alpha] and interleukin-10 mRNA expression was elevated in H. pylori infected mice , but only TNF-alpha mRNA expression was further *increased* by deficiency . Negative_regulation TNF CPOX 19548191 2162486 The cardiovascular protective effect of RCLE seems to be due to an interplay of different factors : pathway activation , [TNF-alpha] *inhibition* , endothelial nitric oxide synthase (eNOS) activation , and free radical and ROS scavenging . Negative_regulation TNF CPP 18771755 1975734 also *attenuated* the expression of inducible nitric oxide synthase and pro-inflammatory cytokines such as IL-1beta and [TNF-alpha] at mRNA levels . Negative_regulation TNF CPZ 7927490 273918 We have previously shown that *inhibits* [tumour necrosis factor (TNF)] production and protects against endotoxic shock in mice . Negative_regulation TNF CPZ 7927490 273919 Both DEX and *inhibited* [TNF] production , whereas induction of IL-1 and IL-6 was inhibited by DEX but not by CPZ . Negative_regulation TNF CPZ 7927490 273922 also *inhibited* spleen associated [TNF] induction in LPS treated mice , suggesting an effect on the synthesis of TNF . Negative_regulation TNF CPZ 7927490 273923 *inhibited* [TNF] induction by Gram positive bacteria ( heat killed Staphylococcus epidermidis ) and by anti-CD3 monoclonal antibodies . Negative_regulation TNF CPZ 7927490 273925 Finally , did not induce the ` rebound ' effect of DEX that , when given 24 hr before LPS , potentiates TNF production , but it did *inhibit* [TNF] production after 24 hr . Negative_regulation TNF CPZ 8550079 339914 ( 1-100 microM ) *inhibited* [TNF-alpha] production in THP-1 cells in a dose dependent manner by a maximum of 80 % . Negative_regulation TNF CPZ 8550079 339915 On the other hand ( 10-25 microM ) also *inhibited* [TNF-alpha] activity : in fact it reduced the cytotoxicity of TNF-alpha on L929 cells ( EC50 was increased four times ) and could provide protection even as a post-treatment . Negative_regulation TNF CPZ 9161877 431838 *down-regulated* [tumor necrosis factor-alpha (TNF-alpha)] and up-regulated IL-10 in mice that then received ConA , whereas delayed administration of CPZ had no effect . Negative_regulation TNF CR2 11120817 758238 Interestingly , early [TNF-alpha] release is also *impaired* in ( null ) and CD19 ( null ) animals , suggesting that these molecules directly affect mast cell activation . Negative_regulation TNF CREB1 20303596 2230464 *Role* of in modulation of [TNFalpha] and IL-10 expression in LPS stimulated RAW264.7 macrophages . Negative_regulation TNF CREB1 20303596 2230505 Our results thus indicate that PKA mediated phosphorylation of *promotes* [TNFalpha] suppression and IL-10 induction , whereas the same phosphorylation event initiated by LPS and mediated by MSK1 is non-functional for transcriptional modulation . Negative_regulation TNF CREB3 20303596 2230465 *Role* of in modulation of [TNFalpha] and IL-10 expression in LPS stimulated RAW264.7 macrophages . Negative_regulation TNF CREB3 20303596 2230506 Our results thus indicate that PKA mediated phosphorylation of *promotes* [TNFalpha] suppression and IL-10 induction , whereas the same phosphorylation event initiated by LPS and mediated by MSK1 is non-functional for transcriptional modulation . Negative_regulation TNF CREB5 20303596 2230463 *Role* of in modulation of [TNFalpha] and IL-10 expression in LPS stimulated RAW264.7 macrophages . Negative_regulation TNF CREB5 20303596 2230504 Our results thus indicate that PKA mediated phosphorylation of *promotes* [TNFalpha] suppression and IL-10 induction , whereas the same phosphorylation event initiated by LPS and mediated by MSK1 is non-functional for transcriptional modulation . Negative_regulation TNF CREM 20018859 2200123 Using TLR2 stimulated dendritic cells , we show that inhibition of [tumor necrosis factor-alpha] production by CGRP is *dependent* on up-regulation of endogenous . Negative_regulation TNF CREM 9545284 498503 Moreover , in Jurkat cells , ectopically expressed *represses* transcription from NFAT mediated , phorbol ester/ionophore activated IL-2 , granulocyte-macrophage colony stimulating factor , and [tumor necrosis factor-alpha] promoters . Negative_regulation TNF CRISPLD2 19864597 2160670 exhibits significant LPS binding affinity similar to that of soluble CD14 , prevents LPS binding to target cells , *reduces* LPS induced [TNF-alpha] and IL-6 production , and protects mice against endotoxin shock . Negative_regulation TNF CRK 12055070 951578 HT-29 cells were treated with [tumor necrosis factor-alpha (TNF-alpha)] in the *presence* or absence of ERK and pathway inhibitors . Negative_regulation TNF CRK 12842450 1108422 SB203580 inhibition of activity did not affect HSP72 expression , or reverse NaArs inhibition of LPS *induced* [TNF] production . Negative_regulation TNF CRK 19052649 1999765 This was followed by MAPK activation and *resulted* in a time dependent increase in [TNF-alpha] production . Negative_regulation TNF CRK 21925494 2492119 The drug also reduced M. leprae induced [TNF-a] production and *inhibited* and ERK1/2 activation . Negative_regulation TNF CRK 23056531 2685364 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit [tumor necrosis factor] a ( TNF-a production in cultured macrophages ) and in vitro MAPK *inhibition* . Negative_regulation TNF CRK 9418855 480508 These findings provide evidence for a *role* of NaSal induced MAPK activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Negative_regulation TNF CRK 9916683 587467 SB 203580 , a selective inhibitor of p38 , blocked and MAPKAPK-2 activation in the T cell clone but did not completely *inhibit* [TNF-alpha] release . Negative_regulation TNF CRY1 20042581 2200483 The treatment with anti-TNF-alpha Ab significantly reduced the severity and halted the progression of the arthritis of Cry1 ( -/- ) Cry2 ( -/- ) mice and vice versa , ectopic expression of in the mouse embryonic fibroblast from Cry1 ( -/- ) Cry2 ( -/- ) mice significantly *reduced* the trans activation of [TNF-alpha] gene . Negative_regulation TNF CSE 21963554 2507343 dose-dependently *inhibited* the expression of pro-inflammatory cytokines IL-1ß and [TNF-a] in IL-1ß stimulated chondrocytes and LPS stimulated THP-1 macrophages . Negative_regulation TNF CSE 23872072 2835310 overexpression *reduced* the ox-LDL stimulated [tumor necrosis factor-a (TNF-a)] generation in Raw264.7 and primary macrophage while CSE knockdown enhanced it . Negative_regulation TNF CSE 24287167 2921380 ( vs no CSE ) *reduced* the mean ( SD ) BCG-driven macrophage ( MDM ) interferon ? ( IFN-? ) , [tumour necrosis factor a (TNF-a)] and interleukin 10 (IL-10) responses by 56.4 ( 18.6 ) % , 67.0 ( 33.4 ) % and 77.7 ( 27.7 ) % , respectively ( p < 0.001 ) . Negative_regulation TNF CSE 24528166 2933372 Similarly , *suppressed* NTHi induced [TNF-a] but not NTHi induced CXCL8 production in COPD alveolar macrophages . Negative_regulation TNF CSE 24528166 2933373 Gene expression analysis showed that *suppressed* LPS induced [TNF-a] transcription but not CXCL8 transcription in COPD alveolar macrophages . Negative_regulation TNF CSF1 14966426 1209029 Electrophoretic mobility shift assay showed that *induced* inhibition of [TNF] production was a result of suppression of nuclear factor-kappaB . Negative_regulation TNF CSF1 2012180 156671 In addition , IL-1 beta and [TNF-alpha] *induced* high levels of granulocyte-macrophage colony stimulating factor ( GM-CSF ) and macrophage colony stimulating factor ( ) mRNAs . Negative_regulation TNF CSF1 7930949 275148 and IL-10 strongly *inhibited* [TNF] production at the level of both mRNA and bioactivity but had no effect on the production of IL-6 . Negative_regulation TNF CSF1 9345022 459281 In the presence of [TNF] , activation of Fas almost completely blocked clonogenic growth of lineage depleted (Lin-) bone marrow ( BM ) progenitor cells in *response* to granulocyte-macrophage colony stimulating factor ( GM-CSF ) , , or a combination of multiple cytokines . Negative_regulation TNF CSF2 11509005 848224 The survival activity of [TNF-alpha] was *inhibited* by anti-TNF-RI , anti-TNF-RII antagonist antibodies and anti-granulocyte-monocyte ( GM-CSF ) neutralizing antibodies but not by anti-interleukin (IL)-3 or anti-IL-5 antibodies . Negative_regulation TNF CSF2 12208854 998096 We investigated the role of Akt and Erk1/2 as LPS intensely stimulates granulocyte/macrophage-colony stimulating factor ( GM-CSF ) release , and neutralizing profoundly suppressed LPS induced inflammation , suppressed expression and activity of lung proteases , significantly *reduced* GM-CSF and [tumor necrosis factor alpha (TNFalpha)] mRNA expression , and dampened nuclear localization of both NFkappaB ( p50/65 ) and AP-1 . Negative_regulation TNF CSF2 12869027 1112128 IgG prevented [TNFalpha] induced CD106 membrane expression and an increase in [ Ca++]i , and *inhibited* the secretion of interleukin-6 (IL-6) and ( M-CSF ) . Negative_regulation TNF CSF2 14966426 1209026 Macrophage *inhibits* [tumor necrosis factor] production and prolongs skin graft survival . Negative_regulation TNF CSF2 15320961 1286589 In contrast , neutralizing using anti-GM-CSF monoclonal antibody ( mAb ) significantly *inhibited* IFN-gamma , [TNF-alpha] , and IL-12p70 elicited by SCG . Negative_regulation TNF CSF2 16157343 1553396 In contrast , significantly *reduced* the production of [TNF-alpha] and IFN-gamma . Negative_regulation TNF CSF2 16985290 1617612 Neutralizing significantly *inhibited* the induction of IFN-gamma , [TNF-alpha] and IL-12p70 by SCG . Negative_regulation TNF CSF2 2012180 156672 In addition , IL-1 beta and [TNF-alpha] *induced* high levels of granulocyte-macrophage colony stimulating factor ( ) and macrophage colony stimulating factor ( M-CSF ) mRNAs . Negative_regulation TNF CSF2 2105994 127029 Although IFN-gamma , IL-6 , granulocyte , and granulocyte-macrophage CSF induced nitroblue tetrazolium reducing activity of U-937 cells , only IFN-gamma , and [TNF] *induced* it synergistically in combination with TGF-beta 1 . Negative_regulation TNF CSF2 9058823 417717 In cultures of murine monocyte/macrophage containing cell populations , i.e. , alveolar , peritoneal , spleen , bone marrow cells , or blood , the presence of or IFN-gamma ( 10 ng/ml ) *resulted* in an enhanced release of [TNF-alpha] initiated by 1 microg/ml LPS . Negative_regulation TNF CSF2 9345022 459282 In the presence of [TNF] , activation of Fas almost completely blocked clonogenic growth of lineage depleted (Lin-) bone marrow ( BM ) progenitor cells in *response* to granulocyte-macrophage ( GM-CSF ) , CSF-1 , or a combination of multiple cytokines . Negative_regulation TNF CSF2 9594023 505923 It could be shown that ( 250 U/ml ) significantly *reduced* IL-1beta induced ( 300 pg/ml ) [TNFalpha] gene expression after 1-h and 3-h incubation periods ( TNFalpha mRNA concentrations were : 8.8+/-2.1 amol/ microg total RNA after a 1-h incubation with IL-1beta versus 3.8+/-1.3 amol/ microg total RNA after a 1-h incubation with IL-1beta + rhG-CSF and 13.8+/-2.2 amol/ microg total RNA after a 3-h incubation with IL-1beta versus 8.8+/-2. 1 amol/ microg total RNA after a 3-h incubation with IL-1beta + rhG-CSF ) . Negative_regulation TNF CSF3 10198397 605240 did not affect rectal temperature or the plasma levels of cortisol and growth hormone but did *induce* increases in the plasma levels of IL-1 receptor antagonist and both soluble [TNF] receptors within 2 h after injection . Negative_regulation TNF CSF3 10607712 655922 in vitro also *attenuated* [TNF-alpha] release from elutriation purified monocytes . Negative_regulation TNF CSF3 12115655 964248 In the *presence* of ( G-CSF ) , the release of IL-1beta and [TNF-alpha] by LPS stimulated human whole blood was suppressed . Negative_regulation TNF CSF3 12115655 964254 For TNF-alpha another mechanism of G-CSF action was identified : [TNF-alpha] as well as proTNF-alpha formation were *inhibited* by , butG-CSF had no influence on LPS induced TNF-alpha mRNA level . Negative_regulation TNF CSF3 1378868 192693 These data suggest that the *mediated* suppression of [TNF] production is not a direct effect of G-CSF on macrophages . Negative_regulation TNF CSF3 14610236 1200455 However , flurbiprofen did not affect *mediated* decrease in [tumor necrosis factor-alpha] or interferon-gamma release . Negative_regulation TNF CSF3 14736711 1242679 LPS induced [TNF-alpha] production was *inhibited* by ( G-CSF ) and interleukin (IL)-10 . Negative_regulation TNF CSF3 14736711 1242681 mediated *inhibition* of LPS induced [TNF-alpha] production as well as G-CSF induced STAT3 phosphorylation and suppressor of cytokine signaling 3 mRNA expression were prevented by pretreatment of monocytes with AG-490 , an inhibitor of Janus kinase 2 . Negative_regulation TNF CSF3 14736711 1242690 These findings suggest that , like IL-10 , *inhibits* LPS induced [TNF-alpha] production in human monocytes through selective activation of STAT3 , and the immunomodulation observed in vivo by G-CSF administration may be partly ascribed to the direct effect of G-CSF on monocyte functions . Negative_regulation TNF CSF3 16436654 1516478 also *down-regulated* [tumor necrosis factor-alpha] and increased activities of Akt signal transducer and activator of transcription-3 , and matrix metalloproteinases . Negative_regulation TNF CSF3 16889627 1638878 By using neutralizing antibodies and G-CSF receptor knockout mice , we demonstrated that secreted from L. rhamnosus GG- and GR-1 exposed macrophages *suppressed* [TNF] production induced by E. coli- or lipopolysaccharide activated macrophages through a paracrine route . Negative_regulation TNF CSF3 17562612 1753504 We also assessed the effect of granulocyte colony stimulating factor ( G-CSF ) pretreatment on TNF-alpha secretion by each cell fraction and found that *reduced* [TNF-alpha] secretion only in the adherent fraction of cells cultured for 3 weeks . Negative_regulation TNF CSF3 18679115 1955272 In model experiments with lipopolysaccharide stimulated human monocytes , recombinant human and interleukin-10 *reduced* the release of [tumor necrosis factor-alpha] by mean 30 % and 92 % , respectively . Negative_regulation TNF CSF3 21566987 290621 t-RA stimulated LPS mediated ( G-CSF ) secretion over two-fold and *inhibited* both LPS mediated granulocyte-macrophage CSF (GM-CSF) and [tumor necrosis factor alpha (TNFalpha)] secretion by as much as 50 % . Negative_regulation TNF CSF3 7545022 318457 did not affect the proliferative response of peripheral blood mononuclear cells ( PBMC ) against allogeneic Daudi cells but did *inhibit* [tumor necrosis factor (TNF)-alpha] secretion . Negative_regulation TNF CSF3 7545022 318458 *mediated* suppression of [TNF-alpha] production was not affected by fixation of stimulators . Negative_regulation TNF CSF3 7545022 318459 did not *inhibit* [TNF-alpha] mRNA expression or accelerate mRNA degradation , whereas pentoxifylline inhibited the expression of TNF-alpha mRNA . Negative_regulation TNF CSF3 8551973 339943 significantly prolonged the survival time of granulocytopenic mice , promoted the clearance of organisms through increasing the counts of PMN in the lung , and strongly *inhibited* the production of [TNF-alpha] both in BALF and serum . Negative_regulation TNF CSF3 8706460 376303 improves survival rate and *reduces* concentrations of bacteria , endotoxin , [tumor necrosis factor] , and endothelin-1 in fulminant intra-abdominal sepsis in rats . Negative_regulation TNF CSF3 8706460 376305 *attenuated* the sepsis induced enhancement of circulating bacteria , endotoxin , [TNF] , and endothelin-1 , resulting in improved fluid balance and reduced lactate concentration . Negative_regulation TNF CSF3 9269759 450108 In group 2 , significantly reduced IL-8 concentrations and modestly *attenuated* [TNF] and IL-6 levels . Negative_regulation TNF CSF3 9594023 505921 *inhibits* [TNFalpha] production in a human hepatoma cell line . Negative_regulation TNF CSK 11310845 804846 Stimulation with also *resulted* in comparable production of [TNF-alpha] in LPS-responder and nonresponder BMDMs from C57Bl/10ScSn mice and C57Bl/10ScCr mice , respectively . Negative_regulation TNF CSN3 16190615 1462611 kappa-Casein , glycomacropeptide , and lactoferrin differentially affected cytokine production by DC : significantly *inhibited* production of [TNF-alpha] , IL-10 , -12 , -6 , and -1beta , independent of sialic acid , whereas less marked effects of glycomacropeptide and lactoferrin were seen . Negative_regulation TNF CSPG4 18715114 1955647 Using the chimeric mice we found that the immediate inhibition of production caused a dramatic effect on the spatial organization of the infiltrating myeloid cells around the lesion site , decreased insulin-like growth factor 1 (IGF-1) production by microglia/macrophages , and *increased* [tumor necrosis factor alpha (TNF-alpha)] levels . Negative_regulation TNF CSPG5 18715114 1955648 Using the chimeric mice we found that the immediate inhibition of production caused a dramatic effect on the spatial organization of the infiltrating myeloid cells around the lesion site , decreased insulin-like growth factor 1 (IGF-1) production by microglia/macrophages , and *increased* [tumor necrosis factor alpha (TNF-alpha)] levels . Negative_regulation TNF CSRP1 23407995 2809621 When human PBMCs were stimulated in vitro with penicillin treated Streptococcus pyogenes , bacterial DNA motifs and lipopolysaccharide with or without synthetic CRP , *suppressed* the production of [TNF-a] and IL-12 , but not that of IFN-? . Negative_regulation TNF CTF1 8952522 400958 *inhibits* [tumor necrosis factor] production in the heart and serum of lipopolysaccharide treated mice and in vitro in mouse blood cells . Negative_regulation TNF CTLA4 10352303 617271 while anti-CD40 and *reduced* IL-10 and [TNF-alpha] levels , anti-CD23 did not affect TNF-alpha while attenuating IL-10 generation . Negative_regulation TNF CTLA4 11481266 843611 *inhibited* the expansion of antigen-specific MAA-T cells and the production of [TNF-alpha] . Negative_regulation TNF CTLA4 17277117 1697817 Indeed , production of the proinflammatory cytokine IFN-gamma , but not [TNF-alpha] , by CD8 T cells was *inhibited* by engagement . Negative_regulation TNF CTLA4 18534002 1939846 Anti-TNF-alpha mAbs and *suppressed* [TNF-alpha] production , whereas anti-IFN-gamma mAbs , anti-IL-12 mAbs , and CTLA-4 Ig inhibited IFN-gamma production . Negative_regulation TNF CTLA4 24295474 2880032 After 3 hours , [ 100 µg/ml ] induced a significant decrease of TNF-a and IL-6 ( p < 0.05 ) , vs. cnt and CTLA4-Ig [ 500 µg/ml ] further *reduced* [TNF-a] ( p < 0.001 ) , vs. cnt . Negative_regulation TNF CTNNB1 12503700 1026842 In human bronchial epithelial cells the authors have shown that [tumour necrosis factor (TNF)-alpha] *induced* a significant decrease of E-cadherin and expression . Negative_regulation TNF CTNND1 8639641 362553 *Role* of , a human homologue to the yeast chromosome segregation gene CSE1 , in toxin and [tumor necrosis factor] mediated apoptosis . Negative_regulation TNF CTR9 1873355 165231 Further , the *role* of released in response to a challenge with LPS in the regulation of [TNF] and IL-6 production was investigated . Negative_regulation TNF CTR9 8514698 221946 Repeated dosing also *resulted* in sustained increased serum [tumor necrosis factor-alpha] levels ( 1,610 +/- 470 pg/ml , P < 0.01 ) and further exacerbation of the leukopenia ( -68 +/- 6 % , P < 0.01 ) and thrombocytopenia ( -65 +/- 8 % , P < 0.01 ) . Negative_regulation TNF CTR9 9403541 469604 Furthermore , inhibiting production with AACOCF3 , or manoalide , also *inhibited* LPS induced Mphi [TNF] mRNA expression . Negative_regulation TNF CTTNBP2 10355820 618201 End phosphorothioated ( ORF4-PE ) significantly *reduced* [TNF-alpha] mRNA levels by greater than 80 % ( p < 0.001 ) and protein levels by 60 % ( p < 0.001 ) in U937 cells . Negative_regulation TNF CTTNBP2 10355820 618202 *reduced* newly synthesized [TNF-alpha] protein levels by > 80 % in lipopolysaccharide (LPS) stimulated human macrophages , by greater than 60 % in phorbol myristate acetate/phyto-hemagglutinin ( PMA/PHA ) -stimulated human peripheral blood mononuclear cells ( PBMC ) , and by approximately 50 % in LPS stimulated murine monocytes . Negative_regulation TNF CUX1 21459047 2438504 When bronchial explants were exposed to Der p and CDP 870 for 24h , 870 *caused* a significant reduction in [TNF-a] release both at baseline and following stimulation with Der p allergen . Negative_regulation TNF CX3CL1 12850572 1109482 dose-dependently *suppressed* the production of nitric oxide ( NO ) , interleukin (IL)-6 and [tumor necrosis factor (TNF)-alpha] with activated microglia . Negative_regulation TNF CX3CL1 15111313 1241124 [Tumor necrosis factor-alpha] *induces* fractalkine expression preferentially in arterial endothelial cells and mithramycin A suppresses TNF-alpha induced expression . Negative_regulation TNF CX3CL1 22093090 2519939 Exogenous *prevented* synergistic Tat and morphine induced dendritic losses and neuron death even though the inflammatory mediator [TNF-a] remained significantly elevated . Negative_regulation TNF CXCL10 21593384 2441508 With regard to pDCs , Notch activation *induced* [TNF-a] whereas Notch inhibition significantly abrogated the secretion of CCL19 , CXCL9 , , and TNF-a . Negative_regulation TNF CXCL10 24219422 2865095 Drug treatments significantly inhibited secretion of in mock infected , but not RV-infected , BE cells , and *inhibited* secretion of [TNFa] under both conditions . Negative_regulation TNF CXCL17 20609401 2303999 In a cellular model of inflammation , inhibited production of nitric oxide ( NO ) and prostaglandin E ( 2 ) ( PGE ( 2 ) ) and *attenuated* expression of [tumor necrosis factor-alpha (TNF-alpha)] , interleukin-6 (IL-6) , IL-1 beta , inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) . Negative_regulation TNF CXXC5 23906331 2830563 Transcription reporter assay and Western blotting showed that *resulted* in activation of [tumor necrosis factor-a (TNF-a)] , initiated the extrinsic apoptosis pathway and cross linked with the intrinsic mitochondrial pathway . Negative_regulation TNF CYBB 15795323 1390309 The aim of this study was to investigate the *role* of containing NADH oxidase signaling in cardiomyocyte [TNF-alpha] expression and myocardial dysfunction induced by LPS . Negative_regulation TNF CYBB 19450605 2096894 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 MAPK and *inhibited* cardiac [TNF-alpha] expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation TNF CYP2C19 17938380 1825684 Renal tumor necrosis factor-alpha and intercellular adhesion molecule-1 expression increased , and expression decreased in ANG/HS hypertension compared with the HS group , and CCR2b inhibition *reduced* [tumor necrosis factor-alpha] and intercellular adhesion molecule-1 and increased Cyp2c23 expression . Negative_regulation TNF DAPK1 22465880 2588972 Conversely , [TNF-a] or INF-? dependent NF-?B activity was further *enhanced* by the inhibition of with its specific siRNA . Negative_regulation TNF DAPK1 24185831 2897000 has been found to *inhibit* [tumor necrosis factor-a (TNF-a)-] or lipopolysaccharides (LPS) induced NF-?B activation and pro-inflammatory cytokine expression . Negative_regulation TNF DAPK2 24185831 2897001 has been found to *inhibit* [tumor necrosis factor-a (TNF-a)-] or lipopolysaccharides (LPS) induced NF-?B activation and pro-inflammatory cytokine expression . Negative_regulation TNF DAPK3 24185831 2897002 has been found to *inhibit* [tumor necrosis factor-a (TNF-a)-] or lipopolysaccharides (LPS) induced NF-?B activation and pro-inflammatory cytokine expression . Negative_regulation TNF DDAH1 15210062 1261854 In cultured ECV304 cells , LDL or ox-LDL markedly *increased* the level of ADMA and [TNF-alpha] and potentiated the adhesion of monocytes to endothelial cells , concomitantly with a significantly decrease in the activity of and serum level of NO . Negative_regulation TNF DDAH2 15210062 1261855 In cultured ECV304 cells , LDL or ox-LDL markedly *increased* the level of ADMA and [TNF-alpha] and potentiated the adhesion of monocytes to endothelial cells , concomitantly with a significantly decrease in the activity of and serum level of NO . Negative_regulation TNF DDB1 10959811 726331 LPS induced I-kappaBalpha degradation and [TNF-alpha] production were also *inhibited* by in RAW264.7 cells , which was consistent with the results in rats . Negative_regulation TNF DDB2 10959811 726332 LPS induced I-kappaBalpha degradation and [TNF-alpha] production were also *inhibited* by in RAW264.7 cells , which was consistent with the results in rats . Negative_regulation TNF DDT 18755234 1975294 However , in presence lipopolysaccharide , *induced* significant ( p < 0.05 ) suppression of [TNF-alpha] and NO generation , suggestive of impairment of macrophage microbiocidal effects . Negative_regulation TNF DDX39B 18381799 1907072 The *role* of in the regulation of [tumor necrosis factor-a] suggests that BAT1 may regulate the inflammatory response observed in patients with RA . Negative_regulation TNF DEFA1 16960100 1627652 Blocking brain *reduces* the high circulating levels of [tumor necrosis factor (TNF)-alpha] in heart failure ( HF ) rats . Negative_regulation TNF DEFB103B 20104491 2241978 In addition , in the presence of LPS , and the murine orthologue Defb14 ( but not hBD2 ) , effectively *inhibit* [TNF-alpha] and IL-6 accumulation implying an anti-inflammatory function . Negative_regulation TNF DEFB103B 20104491 2241981 hBD3 also inhibits CD40/IFN-gamma stimulation of Mphi and in vivo , significantly *reduces* the LPS induced [TNF-alpha] level in serum . Negative_regulation TNF DEFB114 20104491 2241977 In addition , in the presence of LPS , hBD3 and the murine orthologue ( but not hBD2 ) , effectively *inhibit* [TNF-alpha] and IL-6 accumulation implying an anti-inflammatory function . Negative_regulation TNF DEFB114 23482568 2776738 Interestingly , demonstrated novel LPS binding activity in vitro and *inhibited* [TNF-a] release in RAW264.7 cultures through the inhibition of MAPK p42/44 when challenged with LPS . Negative_regulation TNF DEFB123 16790530 1590942 Moreover , *prevented* LPS induced [tumor necrosis factor (TNF)-alpha] secretion in a murine monocyte cell line ( RAW264.7 ) . Negative_regulation TNF DGAT1 16956609 1615746 Activation of gene *results* in increased [tumor necrosis factor-alpha] gene expression in 3T3-L1 adipocytes . Negative_regulation TNF DHPS 23265463 2724916 Furthermore , we found that significantly *inhibited* the production of serum nitric oxide as well as the levels of serum IL-6 , IFN-? , and [TNF-a] in CCl ( 4 ) -treated rats . Negative_regulation TNF DISC1 23423194 2755344 Our findings suggest that the cytoprotective effects of HO-1 are *mediated* by suppression of [TNF/TNFR1] mediated apoptotic signaling , specifically by modulating apoptotic formation and mitochondrial TNFR1 translocation during hepatic I/R . Negative_regulation TNF DISC2 23423194 2755345 Our findings suggest that the cytoprotective effects of HO-1 are *mediated* by suppression of [TNF/TNFR1] mediated apoptotic signaling , specifically by modulating apoptotic formation and mitochondrial TNFR1 translocation during hepatic I/R . Negative_regulation TNF DNAJC5 7524500 272387 also blocks anti-Ig induced TNF-alpha RNA and protein but does not *inhibit* PMA induced [TNF-alpha] . Negative_regulation TNF DNM2 20837769 2319034 Similar blocks in fission of these tubules and in [TNF] secretion *result* from inhibition of the guanosine triphosphatase . Negative_regulation TNF DPH1 15044618 1224868 selectively inhibited TACE enzyme activity in vitro ( K(i) = 2.8 nM ) , and effectively *suppressed* ischemia induced increase in soluble [TNFalpha] in brain tissue after systemic administration . Negative_regulation TNF DPH2 15044618 1224869 selectively inhibited TACE enzyme activity in vitro ( K(i) = 2.8 nM ) , and effectively *suppressed* ischemia induced increase in soluble [TNFalpha] in brain tissue after systemic administration . Negative_regulation TNF DPH3 15044618 1224867 selectively inhibited TACE enzyme activity in vitro ( K(i) = 2.8 nM ) , and effectively *suppressed* ischemia induced increase in soluble [TNFalpha] in brain tissue after systemic administration . Negative_regulation TNF DPH5 15044618 1224865 selectively inhibited TACE enzyme activity in vitro ( K(i) = 2.8 nM ) , and effectively *suppressed* ischemia induced increase in soluble [TNFalpha] in brain tissue after systemic administration . Negative_regulation TNF DPH6 15044618 1224870 selectively inhibited TACE enzyme activity in vitro ( K(i) = 2.8 nM ) , and effectively *suppressed* ischemia induced increase in soluble [TNFalpha] in brain tissue after systemic administration . Negative_regulation TNF DPH7 15044618 1224866 selectively inhibited TACE enzyme activity in vitro ( K(i) = 2.8 nM ) , and effectively *suppressed* ischemia induced increase in soluble [TNFalpha] in brain tissue after systemic administration . Negative_regulation TNF DST 12860292 1111229 In contrast , *inhibited* lipopolysaccharide (LPS) induced NO and [TNF-alpha] production , and the levels of iNOS and TNF-alpha mRNA in a dose dependent manner . Negative_regulation TNF DST 21783458 1506625 In vitro , *suppressed* [TNF-a] secretion with significant reduction at 10 and 100µM BPA . Negative_regulation TNF DUSP1 12444149 1017336 Ectopic expression of accelerated JNK and p38 inactivation and substantially *inhibited* the production of [TNF-alpha] and IL-6 . Negative_regulation TNF DUSP1 15590669 1375111 Adenovirus mediated overexpression significantly *attenuated* [tumor necrosis factor] alpha production in immortalized alveolar macrophages . Negative_regulation TNF DUSP1 16109884 1474091 Furthermore , targeted gene silencing of partially *restored* lipid A-mediated [TNF-alpha] release in HIV+ U1 cells . Negative_regulation TNF DUSP1 16888805 1672721 Expression of the nuclear dual-specific *blocked* [TNFalpha] promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation , indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA induced TNFalpha expression . Negative_regulation TNF DUSP1 20868379 2337162 Here , we show the expression of [tumor necrosis factor-a (TNF-a)] was *reduced* by , expression of which was significantly increased in response to pneumolysin at the early stage of treatment . Negative_regulation TNF DUSP1 21575605 2441477 Alcohol induced downregulation of *leads* to further release of [TNF-a] and hepatic injury . Negative_regulation TNF DUSP1 21733716 2483981 In the current study , specifically dephosphorylated activated MAPK responses and *attenuated* LPS induced IL-6 , IL-10 , and [TNF-a] expression . Negative_regulation TNF DUSP1 22198506 2558712 attenuates ERK1/2 and p38 activation , *inhibits* myocardial [TNF-a] expression , and improves cardiac function in endotoxemia . Negative_regulation TNF ECM1 8093416 210048 Moreover , the level of [TNF] secretion is greatly enhanced in the *presence* of physically damaged ( dECM ) . Negative_regulation TNF ECM2 8093416 210049 Moreover , the level of [TNF] secretion is greatly enhanced in the *presence* of physically damaged ( dECM ) . Negative_regulation TNF EDN1 20193475 2216302 Our results indicate that the selective ET-1R antagonist BQ123 not only reduces the increase of mPAP and serum level , but also *inhibits* the production of [TNF-alpha] , and attenuates the local inflammatory response induced by APTE . Negative_regulation TNF EDNRA 10229544 611042 also *suppressed* [TNF] production by alveolar macrophages ( AMs ) stimulated with LPS in vitro . Negative_regulation TNF EEF1A2 21883905 2496440 In vitro , decreased PKC?/I?Ba activation and IL-2/IFN-? production in ConA stimulated spleen T cells , and *diminished* [TNF-a/IL-1ß] in macrophage-T cell cocultures . Negative_regulation TNF EEF1E1 18327539 1919580 Antimicrobial peptide markedly *inhibited* the expression of inducible nitric oxide synthase (iNOS) , [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 beta (IL-1beta) in lipopolysaccharide (LPS) stimulated RAW264.7 macrophage cells , whereas magainin 2 did not inhibit these activities . Negative_regulation TNF EGF 10788429 688558 In the EAhy926 endothelial cell line , UTP , ATP , and forskolin , but not UDP and , *inhibited* [tumor necrosis factor alpha (TNFalpha)-] and sorbitol stimulation of the stress activated protein kinases , JNK , and p38 mitogen activated protein (MAP) kinase , and MAPKAP kinase-2 , the downstream target of p38 MAP kinase . Negative_regulation TNF EGF 12795334 1098412 Suppression of [TNF-alpha] *mediated* apoptosis by in TNF-alpha sensitive human cervical carcinoma cell line . Negative_regulation TNF EGF 14667973 1178035 Treatment with P4 augmented and Bcl-2 protein expression , but *inhibited* IGF-I and [TNFalpha] expression in cultured leiomyoma cells . Negative_regulation TNF EGFR 17934341 1813462 Genistein , a protein tyrosine kinase (PTK) inhibitor , and PD153035 , an EGFR inhibitor , also blocked the increase of TNF-alpha expression by TCDD , indicating the *role* of in TCDD induced [TNF-alpha] expression . Negative_regulation TNF EGFR 18701712 1950522 [TNF] stimulated EGFR phosphorylation in young adult mouse colon epithelial cells , and loss of expression or inhibition of kinase activity *increased* TNF induced apoptosis , which was prevented in WT but not by kinase-inactive EGFR expression . Negative_regulation TNF EGR1 21415413 2432108 ( -/- ) mice exhibit increased liver injury after carbon tetrachloride ( CCl ( 4 ) ) exposure and *reduced* [TNF-a] production . Negative_regulation TNF EGR1 7585181 333651 and 5,000 cGy ( rad ) *resulted* in increased intratumoral [TNF-alpha] production and increased tumour control compared with treatment with Ad5 . Negative_regulation TNF EGR2 7585181 333652 and 5,000 cGy ( rad ) *resulted* in increased intratumoral [TNF-alpha] production and increased tumour control compared with treatment with Ad5 . Negative_regulation TNF EGR3 7585181 333653 and 5,000 cGy ( rad ) *resulted* in increased intratumoral [TNF-alpha] production and increased tumour control compared with treatment with Ad5 . Negative_regulation TNF EGR4 7585181 333654 and 5,000 cGy ( rad ) *resulted* in increased intratumoral [TNF-alpha] production and increased tumour control compared with treatment with Ad5 . Negative_regulation TNF EHHADH 22142871 2517552 Real-time PCR analysis of the aorta showed that significantly *prevented* the upregulation of the vascular cell adhesion molecule (VCAM)-1 , intercellular adhesion molecule (ICAM)-1 , [TNF-a] , IL-6 , and IL-1ß expression . Negative_regulation TNF EHMT1 23370161 2754558 Results showed that significantly *reduced* the levels of serum IL-6 and [TNF-a] levels and increased the levels of serum IL-2 , IL-4 and IL-10 in GLP treated rats compared to gastric cancer model rats . Negative_regulation TNF EIF1 22592805 2625164 MIF and TNF-a levels were increased in 6-CATT compared with 5-CATT patients with CF. LPS induced [TNF-a] production from PBMCs was attenuated in the *presence* of . Negative_regulation TNF ELANE 9758732 536309 Methylprednisolone treatment effectively inhibited the increases in [TNF-alpha] and IL-6 and the decreases in AT-III and albumin , but did not *inhibit* the increases in and TAT levels . Negative_regulation TNF EMD 16677290 1559060 We found that *attenuated* the release of [TNF-alpha] and interleukin-8 in whole blood from healthy donors challenged by lipopolysaccharide or peptidoglycan , while the release of interleukin-10 was unchanged . Negative_regulation TNF ENO1 21803152 2521600 and calreticulin siRNA *reduced* the [ Ca ( 2+ ) ] i levels , amounts of total TNF-a , and the release of [TNF-a] and leukotrienes , all of which are increased in the BMMCs activated with antigen/antibody reaction . Negative_regulation TNF ENPEP 7788449 313071 Several ARA and *inhibited* monocyte [TNF] production in a concentration dependent manner . Negative_regulation TNF ENPP3 7590909 334254 In solid-phase ELISA , <3B10> *inhibited* the binding of [TNF-alpha] to soluble TNF receptors , sTNF-RI and sTNF-RII . Negative_regulation TNF EPB41 20299954 2273023 Furthermore , expression in primary CD4 T cells *results* in increased production of interleukin (IL)-2 , IL-15 and [tumor necrosis factor (TNF)] , as well as IL-1RA ; Negative_regulation TNF EPHB2 11777978 899857 In contrast , SmO induction of the ERK pathway was increased compared with the SmT morphotype , and inhibition of *resulted* in decreased [TNF-alpha] synthesis and enhanced SmO growth . Negative_regulation TNF EPHB2 12867362 1149939 JNK mainly regulates TNF-alpha transcription and apoptosis , whereas and p38 *contribute* to the regulation of [TNF-alpha] production , probably through posttranscriptional mechanisms . Negative_regulation TNF EPHB2 14715932 1197415 Together , these findings indicate that both and JNK are *involved* in the regulation of [TNF] mRNA expression , that p38 is involved in the nucleocytoplasmic transport of TNF mRNA , and that a PTK ( protein tyrosine kinase ) , possibly a member of the src family , acts downstream of the P2X7 receptor to activate JNK and p38 . Negative_regulation TNF EPHB2 16207331 1464310 In vivo , overexpression of [TNF] *induced* activation of p38MAPKalpha and in the synovial membrane , whereas activation of JNK was less pronounced and rarely observed on immunohistochemical analysis . Negative_regulation TNF EPHB2 19561104 2104172 We determined that acute alcohol decreased but chronic alcohol increased activation of ERK in monocytes and inhibitor , PD98059 , *prevented* the chronic alcohol induced increase in [TNF-alpha] . Negative_regulation TNF EPHB2 19778233 2141040 The induction of [TNF-alpha] and TGF-beta1 by silica was *suppressed* by Src inhibitor ( PP1 ) , inhibitor ( PD98059 ) , but not by p38 kinase inhibitor ( SB203580 ) . Negative_regulation TNF EPHB2 19864500 2187792 Moreover , alone *suppressed* [TNF-alpha] and FasL and inhibited TNF-family mediated extrinsic apoptosis in H9N2 infected chicken macrophages . Negative_regulation TNF EPHB2 20161729 2215146 Berberine significantly *inhibited* HIV PI-induced [TNF-alpha] and IL-6 expression by modulating ER stress signaling pathways and subsequent activation , in turn preventing the accumulation of the RNA binding protein HuR in cytosol and inhibiting the binding of HuR to the 3'-UTRs of TNF-alpha and IL-6 in macrophages . Negative_regulation TNF EPHB2 20851927 2388987 Inhibition of p38 , but not , *attenuated* production of both IL12/IL23p40 and [TNF-a] . Negative_regulation TNF EPHB2 21042558 2344362 Genistein represses the release of [TNF-a] and significantly *inhibits* and P38 phosphorylation in activated microglial cells by acting as a tyrosine kinase inhibitor . Negative_regulation TNF EPHB2 22203480 2568866 Blocking or Akt by pharmacological agent *reduced* [TNF-a] or NO production in MMD overexpressing macrophages , respectively . Negative_regulation TNF EPHB2 23285207 2711791 Ber or/and Y all *inhibited* LPS stimulated I?Ba , JNK and phosphorylation , NF-?B activation as well as [TNF-a] production . Negative_regulation TNF EPHB2 23973554 2873380 The TCI induced activation of astrocytes and microglial cells , as well as the increased levels of IL-1ß and [TNF-a] , were *inhibited* by intrathecal administration of TLR4 targeting siRNA2 and the EphB receptor antagonist , respectively . Negative_regulation TNF EPO 16487143 1524838 *reduces* Schwann cell [TNF-alpha] , Wallerian degeneration and pain related behaviors after peripheral nerve injury . Negative_regulation TNF EPO 1712553 161229 A dose dependent decrease of up to 60 % in production was *induced* by interleukin-1 beta , interleukin-1 alpha , and [tumor necrosis factor-alpha] ( in that order of potency ) . Negative_regulation TNF EPO 19493399 2091462 attenuates pulmonary inflammation and *suppresses* [TNF-alpha] and IL-1beta overproduction during acute endotoxaemia , which is partially mediated by inhibition of NF-kappaB . Negative_regulation TNF EPOR 16982324 1617108 Impaired BM erythropoiesis in CIN patients is probably the result of increased local production of [TNF-alpha] and IFN-gamma that *induce* apoptosis , cell growth inhibition , and downregulation of expression on erythroid cells . Negative_regulation TNF EPS15 19655406 2119142 In addition , ( 2.25 , 4.5 g/kg , ig 9 days ) *inhibited* the expression of [TNF-alpha] and IL-1beta and the biological activity of NF-kappaB . Negative_regulation TNF EPS8 19655406 2119143 In addition , ( 2.25 , 4.5 g/kg , ig 9 days ) *inhibited* the expression of [TNF-alpha] and IL-1beta and the biological activity of NF-kappaB . Negative_regulation TNF EPX 12363412 995168 *delayed* the increase of [TNF] levels , without altering their peak levels , and markedly reduced those of IL-6 suggesting that the decreased inflammation and clinical score may be in part upon attenuation of IL-6 . Negative_regulation TNF EPX 19501490 2202625 *attenuated* the LA , PA , BBB and behavioral dysfunctions and serum [TNF] levels 4h after CLP in both WT and ob/ob mice , and P-sel in ob/ob CLP mice . Negative_regulation TNF EPX 21228694 2379614 improved pain related behavior and *reduced* the expression of p-p38 and [TNF-a] . Negative_regulation TNF EPX 21729562 2452042 It is concluded that can *inhibit* the expression of IL-6 and [TNF-a] in monocytes , and the inhibition of IL-6 expression may be associated with decrease of PARP level . Negative_regulation TNF ERBB2 18701712 1950525 [TNF] also activated ErbB2 , and loss of expression *increased* TNF induced apoptosis . Negative_regulation TNF ERG 11719371 883680 It has recently been shown that the transcription factor , an Ets family member , drives constitutive expression of the intercellular adhesion molecule 2 ( ICAM-2 ) in human umbilical vein endothelial cells ( HUVECs ) and that its expression is *down-regulated* by the pleiotropic cytokine [tumor necrosis factor alpha (TNF-alpha)] . Negative_regulation TNF ERP27 22710295 2626786 In addition , also remarkably *inhibited* the protein and mRNA levels of iNOS , COX-2 , [TNF-a] , IL-1ß , and IL-6 . Negative_regulation TNF ERP27 24385881 2883665 Preliminary mechanism studies demonstrated that decreased the level of MPO and MDA , increased the activities of anti-oxidant enzymes ( SOD , GPx , and GRd ) , *attenuated* the productions of [TNF-a] , IL-1ß , IL-6 , PGE2 and NO , and suppressed the activities of COX-2 and iNOS . Negative_regulation TNF ERP29 22710295 2626784 In addition , also remarkably *inhibited* the protein and mRNA levels of iNOS , COX-2 , [TNF-a] , IL-1ß , and IL-6 . Negative_regulation TNF ERP29 24385881 2883663 Preliminary mechanism studies demonstrated that decreased the level of MPO and MDA , increased the activities of anti-oxidant enzymes ( SOD , GPx , and GRd ) , *attenuated* the productions of [TNF-a] , IL-1ß , IL-6 , PGE2 and NO , and suppressed the activities of COX-2 and iNOS . Negative_regulation TNF ERP44 22710295 2626785 In addition , also remarkably *inhibited* the protein and mRNA levels of iNOS , COX-2 , [TNF-a] , IL-1ß , and IL-6 . Negative_regulation TNF ERP44 24385881 2883664 Preliminary mechanism studies demonstrated that decreased the level of MPO and MDA , increased the activities of anti-oxidant enzymes ( SOD , GPx , and GRd ) , *attenuated* the productions of [TNF-a] , IL-1ß , IL-6 , PGE2 and NO , and suppressed the activities of COX-2 and iNOS . Negative_regulation TNF ERVK-6 15265236 1275284 A activating peptide , tc-LIGRLO-NH2 , *induces* protease release from mast cells : role in [TNF] degradation . Negative_regulation TNF ESAM 7545397 318533 Inhibition of [tumor necrosis factor] *induced* human aortic gene expression by an alkoxybenzo [ b ] thiophene-2-carboxamide . Negative_regulation TNF ESAT 19265145 2045511 also *inhibited* T cell production of IL-17 and [TNF-alpha] but not IL-2 . Negative_regulation TNF ESAT 20006311 2174914 also *inhibited* T-cell production of IL-17 and [TNF-a] , but not IL-2 . Negative_regulation TNF ETS1 8284209 240682 The -76/-56 region contains three direct repeats of the ets-core sequence GGAA that are important for specific high basal activity , [TNF alpha] *repression* and trans-activation by expression of and 2 . Negative_regulation TNF ETV6 18403658 1932196 also *reduced* protein , nitrite , MIP-2 , and [TNF-alpha] levels in the BAL fluid of LPS nebulized animals . Negative_regulation TNF EZH2 23918984 2830791 WSN virus infection induced expression of [TNF-a] , IFN-ß , and IL-8 is *inhibited* by and its catalytic dead form ?SET . Negative_regulation TNF F10 23519930 2909039 It was shown that the viability , phagocytic activity , NO production , [TNF-a] production and activity in peritoneal macrophages after activation by lipopolysaccharide were *suppressed* by , while the suppressions were fully or partially antagonized by Gl-PS . Negative_regulation TNF F10 23872307 2895630 Active-site blockade , ?-carboxyglutamic acid domain truncation and a peptide mimic of the factor Xa inter-epidermal growth factor-like region prevented *inhibition* of lipopolysaccharide induced [tumor necrosis factor-a] release . Negative_regulation TNF FANCC 19850743 2170171 In conclusion , *suppresses* [TNF-alpha] production in mononuclear phagocytes by suppressing TLR8 activity and this particular function of FANCC is independent of its function in protecting the genome from cross linking agents . Negative_regulation TNF FANCD2 21912593 2479267 Therefore , we propose deficiency *promotes* transcriptional activity of the [TNF-a] promoter and induces overproduction of TNF-which then sustains prolonged inflammatory responses . Negative_regulation TNF FAS 11561906 862733 We conclude that TGF-beta as well as [TNF-alpha] may *act* as surviving factors for activated rat HSC not only through reduction of gene expression but also by upregulating the anti-apoptotic factors NFKB , bcl-xL and p21WAF1 and by downregulating the proapoptotic factor p53 . Negative_regulation TNF FAS 12505729 1038260 PD analyses suggested that in NHS samples containing CsA+SRL ( n=5 ) , ( 1 ) PMA-Ionomycin stimulated T-cell expression of intracellular IL-2 , [TNF-alpha] , and IFN-gamma was inhibited by CsA , and minimally by SRL , and ( 2 ) the two agents *inhibited* pokeweed mitogen ( PWM ) -stimulated B-cell expression of CD54 and , but not CD86 ( ICAM-1 , Fas antigen , and B7.2 ) , synergistically . Negative_regulation TNF FAS 9345022 459280 In the presence of [TNF] , activation of almost completely *blocked* clonogenic growth of lineage depleted (Lin-) bone marrow ( BM ) progenitor cells in response to granulocyte-macrophage colony stimulating factor ( GM-CSF ) , CSF-1 , or a combination of multiple cytokines . Negative_regulation TNF FASLG 11023984 738422 Blocking of *reduced* apoptosis by 50 % and simultaneous blocking of FasL and [TNF] receptors by 70 % . Negative_regulation TNF FASLG 12176740 975491 Inhibition of NF-kappaB by a specific NF-kappaB inhibitor , caffeic acid phenylethyl ester , or by dominant expression of the NF-kappaB inhibitory subunit IkappaB caused an increase in *induced* apoptosis and a reduction in [TNF-alpha] expression . Negative_regulation TNF FASN 23319743 2742916 We also show that overexpression *suppresses* [tumor necrosis factor-a] production and nuclear factor-?B activation as well as drug induced activation of neutral sphingomyelinase . Negative_regulation TNF FCER1G 10438475 634830 Expression of a mutated ( T60A ) , in either FcepsilonRIgamma-deficient or gamma-null mast cells , *resulted* in a delay of FcepsilonRI endocytosis , inhibition of [TNF-alpha] mRNA production , and inhibition of degranulation but did not affect FcepsilonRI induced cell adhesion . Negative_regulation TNF FCGR1A 12746896 1088806 Consistent with these effects on SF macrophages , also *inhibited* [TNFalpha] production , interleukin-1beta production , and cartilage degrading activity of RA synovial tissue explants . Negative_regulation TNF FCGR2B 15843524 1398437 In vitro it was shown that absence of under tolerogenic conditions *led* to increased IgG induced release of inflammatory cytokines such as MCP-1 , [TNF-alpha] , and IL-6 by bone marrow derived DC , and increased their expression of costimulatory molecules , resulting in an altered immunogenic T cell response associated with increased IL-2 and IFN-gamma secretion . Negative_regulation TNF FCGR2B 17082598 1643226 The blockade inhibits GXM induced IL-10 production and *induces* [TNF-alpha] secretion . Negative_regulation TNF FES 16874150 1593510 also *causes* a significant reduction of [TNF-alpha] ( -11.5+/-8.9 % ) , sICAM-1 ( -13.1+/-9.8 % ) , and sVCAM-1 ( -10.6+/-6.6 % ) , as well as a respective increase in the ratio IL-10/TNF-alpha ( 37.1+/-29.4 % ) . Negative_regulation TNF FLOT2 23671449 2785107 Meanwhile , *reduced* the serum IL-6 and [TNF-a] levels ( p < 0.05 ) , inhibited the expression of PCNA and promoted the expression of caspase-3 , Fas and FasL in animals of the treated group ( p < 0.05 ) . Negative_regulation TNF FMR1 10409155 629866 *inhibits* [TNF-alpha] release after LPS administration . Negative_regulation TNF FMR1 12921647 1130992 *induced* a dose dependent suppression of the spontaneous [TNF-alpha] release from AM in sarcoidosis ( P < 0.001 ) , while the spontaneous release of other cytokines was unaffected by POF at all tested concentrations , but a trend for the inhibition of IL-10 production was found ( P = 0.092 ) . Negative_regulation TNF FMR1 14555589 1153139 The results showed that *induced* a dose dependent suppression of the spontaneous [TNF-alpha] release from AMs in sarcoidosis ( p < 0.001 ) , and that the spontaneous release of the other cytokines was unaffected by POF at all tested concentrations , but a trend for the inhibition of IL-10 production was found ( p = 0.092 ) . Negative_regulation TNF FMR1 15061967 1230590 *induced* a dose dependent suppression of spontaneous [TNFalpha] and IL-10 release from AM in EAA ( P < 0.001 and P < 0.05 ) . Negative_regulation TNF FMR1 17436095 1783618 In this LPS stimulated culture system , *caused* a dose dependent suppression of [TNF-alpha] levels ( P < 0.001 , ANOVA on ranks for repeated measures ) . Negative_regulation TNF FMR1 2344657 134795 was found to *inhibit* the appearance of [TNF] in serum of LPS treated , D-galactosamine sensitized mice and in the supernatants of LPS stimulated , thioglycollate induced mouse peritoneal macrophages . Negative_regulation TNF FMR1 7615305 314522 We could demonstrate that ( above 4.10 ( -4 ) M ) *inhibited* the secretion of superoxide anion and [TNF-alpha] by AM in a dose dependent manner via a prostaglandin synthesis dependent mechanism that was independent of the glucocorticoid receptor . Negative_regulation TNF FMR1 9144910 429684 The course of L. monocytogenes infection was followed in mice treated with , a known *inhibitor* of endogenous [tumor necrosis factor (TNF)] formation . Negative_regulation TNF FMR1 9927365 588553 The aim of this study was to investigate whether *induced* suppression of [TNF-alpha] secretion affects peripheral blood monocytes ( PBM ) and alveolar macrophages ( AM ) equally , and whether POF is able to suppress the spontaneous TNF-alpha production from AM in pulmonary sarcoidosis in vitro . Negative_regulation TNF FMR1 9927365 588555 *induced* a dose dependent suppression of the LPS stimulated [TNF-alpha] production which was not different for PBM and AM , respectively . Negative_regulation TNF FMR1 9927365 588557 In sarcoidosis , *inhibited* the spontaneous [TNF-alpha] production of AM at 0.1 mM by 91 % and at 1 mM by 98 % . Negative_regulation TNF FMR1 9927365 588558 In conclusion , *inhibits* LPS induced [TNF-alpha] production from PBM and AM to a similar extent and can also inhibit the exaggerated spontaneous TNF-alpha production from AM in sarcoidosis in vitro . Negative_regulation TNF FN1 8871661 389605 Neither fibronectin nor laminin effected cytokine receptor expression during normoxia , but both and laminin significantly *reduced* IL-1beta type I , [TNF-alpha] ( p80 ) , and IL-8R expression during hypoxia . Negative_regulation TNF FN1 8871661 389607 Following H/R , both and laminin significantly *reduced* IL-1beta type I , [TNF-alpha] ( p80 ) , and IL-8R expression during hypoxia . Negative_regulation TNF FOS 16358608 1492986 A transient elevation of c-Fos and c-Jun messenger RNAs was *induced* by [TNF-alpha] , whereas COX-2 inhibitors NS-398 and meloxicam abolished the up-regulation of . Negative_regulation TNF FOS 23107698 2695279 Furthermore , pre- and post treated ( 0.1-100 µg/ml ) dose-dependently *suppressed* [TNF-a] , IL-1ß , IL-6 and NO production , and induced IL-10 production in lipopolysaccharide (LPS) stimulated RAW264.7 cells without exerting cytotoxicity . Negative_regulation TNF FOXA1 11053014 745135 Taken together these data indicated that in NCI-H441 cells 1 ) [TNF-alpha] inhibition of SP-B promoter activity may be *caused* by decreased binding activities of TTF-1 and HNF-3 elements , 2 ) the decreased binding activities of TTF-1 and are not due to decreased nuclear levels of the proteins , and 3 ) okadaic acid-sensitive phosphatases may be involved in mediating TNF-alpha inhibition of SP-B promoter activity . Negative_regulation TNF FOXE1 10465294 640568 These data suggest that is *involved* in the [TNF-alpha] and IFN-gamma induced suppression of thyroid-specific gene expression . Negative_regulation TNF FOXM1 11053014 745134 Taken together these data indicated that in NCI-H441 cells 1 ) [TNF-alpha] inhibition of SP-B promoter activity may be *caused* by decreased binding activities of TTF-1 and elements , 2 ) the decreased binding activities of TTF-1 and HNF-3 alpha are not due to decreased nuclear levels of the proteins , and 3 ) okadaic acid-sensitive phosphatases may be involved in mediating TNF-alpha inhibition of SP-B promoter activity . Negative_regulation TNF FOXO3 21294163 2388299 *inhibits* [TNF-a-] and IL-1ß induced astrocyte proliferation : Implication for reactive astrogliosis . Negative_regulation TNF FOXO3 23860688 2849465 In addition , we have researched that the overexpressed could specially *inhibit* the release of [TNF-a] increased by ATP , but the level of IL-6 induced by ATP was not decreased . Negative_regulation TNF FOXO4 23860688 2849438 However , ATP had no effect on the expression of and FOXO6 , and EGFR , Akt , and ERK1/2 all *involve* in the release of interleukin (IL)-6 and [tumor necrosis factor-a (TNF-a)] induced by ATP . Negative_regulation TNF FOXO6 23860688 2849437 However , ATP had no effect on the expression of FOXO4 and , and EGFR , Akt , and ERK1/2 all *involve* in the release of interleukin (IL)-6 and [tumor necrosis factor-a (TNF-a)] induced by ATP . Negative_regulation TNF FOXP3 21873519 2486592 In response to activation by endothelial Ag presentation or immobilized anti-CD3e , ( + ) iTreg *suppressed* [TNF-a-] and IL-1ß mediated endothelial selectin expression and adhesiveness to effector T cells . Negative_regulation TNF FSCN1 15625085 1387895 The TNF receptor *mediates* [TNF] inhibition of osteoblast differentiation independently of apoptosis . Negative_regulation TNF FURIN 17283058 1718386 *Role* for in [tumor necrosis factor] alpha induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway . Negative_regulation TNF FXR1 15548538 1367749 Finally , we found that the ablation of FXR1P led to a dramatically enhanced association of the TNF mRNA with polyribosomes demonstrating the important *role* of in the post-transcriptional regulation of [TNF] expression . Negative_regulation TNF FXR1 19028791 2022891 activation by natural and synthetic ligands in these cell types *attenuated* IL-1beta , IL-6 , and [TNF-alpha] gene induction in response to Toll-like receptor 4 activation by LPS . Negative_regulation TNF FXR2 19028791 2022892 activation by natural and synthetic ligands in these cell types *attenuated* IL-1beta , IL-6 , and [TNF-alpha] gene induction in response to Toll-like receptor 4 activation by LPS . Negative_regulation TNF FYN 20335178 2260493 Decreased Gab2 but not *reduced* the FcepsilonRI induced activation of the Erk , Jnk , and p38 MAP kinases and the release of [TNF-alpha] . Negative_regulation TNF GAB1 12065326 954386 Gab1 associated with MEKK3 , and a catalytically inactive form of MEKK3 inhibited TNF-alpha induced c-Jun and NF-kappaB transcriptional activation , suggesting a critical *role* for and MEKK3 in [TNF-alpha] signaling . Negative_regulation TNF GAB2 20335178 2260492 Decreased but not Fyn *reduced* the FcepsilonRI induced activation of the Erk , Jnk , and p38 MAP kinases and the release of [TNF-alpha] . Negative_regulation TNF GAL 12507772 1038442 Even at very low concentrations , *inhibited* tumor necrosis factor-alpha (TNF alpha) release but not [TNF alpha] mRNA levels in LPS stimulated BV2 cells . Negative_regulation TNF GAL 12507772 1038443 Thus , *inhibits* [TNF alpha] production by a post-transcriptional mechanism that both prevents the efficient addition of the poly ( A ) tail and accelerates TNF alpha mRNA degradation . Negative_regulation TNF GAL 21253857 2402948 NF?B activation in macrophages and [TNF-a] production were *suppressed* in macrophages by Man-liposome/NF?B decoy complexes but not by the naked NF?B decoy , decoy complexes , or Man-liposome/random decoy complexes . Negative_regulation TNF GAL 8618866 337603 Polyclonal anti-lectin serum specifically inhibited [TNF-alpha] mRNA induction in *response* to the but not to lipopolysaccharide . Negative_regulation TNF GAL 9199414 438939 Antilectin monoclonal antibody IG7 , which recognizes a domain ( amino acids 596 to 818 ) of the TNF-alpha mRNA stimulating region of Gal-lectin , specifically inhibited [TNF-alpha] and iNOS mRNA induction and TNF-alpha and NO production by primed BMM in *response* to ( 100 ng/ml ) . Negative_regulation TNF GAL 9521071 493703 Gene transfer with hIL-4 reduced the serum [tumor necrosis factor (TNF)-alpha] production in *response* to by 80 % from 113.1 pg/ml in mock transfected animals to 22.2 pg/ml ( p < 0.05 ) ; Negative_regulation TNF GAS6 20103767 2241973 *inhibits* [TNF-alpha] and IL-6 secretion by LPS stimulated U937 cells and monocytes/macrophages . Negative_regulation TNF GCH1 11832086 766555 Treatment with pentoxifylline significantly decreased plasma biopterin and [TNF] levels at 2 to 8 hours after endotoxin challenge ( P < 0.05 , P < 0.01 ) , and *inhibited* activities in the liver , lung , and myocardial tissues ( P < 0.05 ) . Negative_regulation TNF GCLC 12433058 1015654 Inhibition of , the rate limiting enzyme in the biosynthesis of GSH , by the action of L-buthionine- ( S , R ) -sulfoximine ( BSO ) , *potentiated* LPS induced IL-1beta , IL-6 and [TNF-alpha] production . Negative_regulation TNF GDNF 20632386 2316663 Our results showed that resulted in a significant reduction in enhanced permeability , *inhibited* MPO activity , IL-1beta and [TNF-alpha] expression , and increased ZO-1 and Akt expression . Negative_regulation TNF GEMIN4 20100830 2219265 Transient expression of either or PP2Ac was *sufficient* to elevate levels of the dual specificity phosphatase DUSP1 , reduce p38 MAPK activation , and suppress [tumor necrosis factor-alpha] release . Negative_regulation TNF GGA1 12023001 943479 During the 24-hour postoperative period , significantly suppressed the release of aspartate or alanine aminotransferase and elevation of the serum interleukin-6 level , and completely *inhibited* an increase in the serum level of [tumor necrosis factor-alpha] . Negative_regulation TNF GGA2 12023001 943477 During the 24-hour postoperative period , significantly suppressed the release of aspartate or alanine aminotransferase and elevation of the serum interleukin-6 level , and completely *inhibited* an increase in the serum level of [tumor necrosis factor-alpha] . Negative_regulation TNF GGA3 12023001 943478 During the 24-hour postoperative period , significantly suppressed the release of aspartate or alanine aminotransferase and elevation of the serum interleukin-6 level , and completely *inhibited* an increase in the serum level of [tumor necrosis factor-alpha] . Negative_regulation TNF GH1 10198397 605241 G-CSF did not affect rectal temperature or the plasma levels of cortisol and but did *induce* increases in the plasma levels of IL-1 receptor antagonist and both soluble [TNF] receptors within 2 h after injection . Negative_regulation TNF GH1 11038815 479689 Somastostain and *inhibited* the inflammatory mediates and [TNF alpha] mRNA overexpression and reduced the damage to the pancreas and liver . Negative_regulation TNF GH1 16777921 1672111 activated STAT5 , and directly *reduced* [TNFalpha] activation of NFkappaB , in T84 cells . Negative_regulation TNF GHSR 17911350 1830208 inhibition by the administration of a GHSR-la antagonist , [ d-Arg(1) , d-Phe ( 5 ) , d-Trp ( 7,9 ) , Leu ( 11 ) ] substance P , significantly *increased* both NE and [TNF-alpha] levels even in normal animals . Negative_regulation TNF GIF 19527463 2098637 , a [tumor necrosis factor-alpha (TNF-alpha)] *inhibitor* , is an effective drug for patients with rheumatoid arthritis ( RA ) . Negative_regulation TNF GLAT 14975587 1212885 In unseparated macrophages ( MPhi ) and MPhi of low density , GLAT enhanced constitutive and LPS induced production of interleukin 10 (IL-10) while LPS induced synthesis of [tumor necrosis factor-alpha (TNF-alpha)] was dose-dependently *suppressed* by . Negative_regulation TNF GLAT 19609087 2137367 IFNbeta treatment increased the proportion of IFNgamma producing CD4+ lymphocytes ( p = 0.003 ) whereas *reduced* [TNF] production ( p = 0.012 ) . Negative_regulation TNF GLAT 19609087 2137368 *reduced* IL12p40 ( p < 0.001 ) , IFNgamma ( p = 0.001 in CD4+ and CD8+ lymphocytes ) and [TNF] production of leukocytes ( p < 0.001 ) . Negative_regulation TNF GLMN 18062237 1833918 Nonetheless , AP and both *inhibited* the mRNA expression of IL-6 and [TNF-alpha] in IgE induced RBL-2H3 cells . Negative_regulation TNF GML 19838303 2155068 *suppressed* [TNF-alpha] at the infection site on day 7 ; Negative_regulation TNF GP1BA 12815041 1120753 Moreover , *inhibits* the [TNF alpha] production induced by T. gondii GPI or by GPIa . Negative_regulation TNF GP1BB 12815041 1120754 Moreover , *inhibits* the [TNF alpha] production induced by T. gondii GPI or by GPIa . Negative_regulation TNF GP2 19214384 2050144 In addition , ZPDC ( 200 microg/ml ) not only diminished the production of superoxide anion , hydrogen peroxide , and nitric oxide , but also *suppressed* the expression of pro-inflammatory cytokines ( IL-1 beta , IL-6 , and [TNF-alpha] ) and proteins ( iNOS , COX-2 , and MMP-9 ) in LPS- stimulated RAW 264.7 cells . Negative_regulation TNF GP2 19885859 2188231 Our results revealed that the CTB in the presence of DEHP *inhibits* the release of histamine and expression of interleukin (IL)-4 , IL-6 , and [TNF-alpha] in RBL-2H3 cells . Negative_regulation TNF GP2 19885859 2188247 The results from these experiments indicated that the CTB *inhibits* release of histamine and expressions of IL-4 , IL-6 , and [TNF-alpha] via down regulations of PKC/MAPK and NF-kappaB on the stage of mast cell degranulation induced by DEHP . Negative_regulation TNF GP2 20499049 2276347 Expression of [TNF-alpha] and IL-6 in HMC-1 cells treated with bisphenol A is *attenuated* by plant originating ( 75 kDa ) by blocking p38 MAPK . Negative_regulation TNF GP2 20499049 2276381 The results obtained from this study revealed that CTB ( 100 microg/ml ) *inhibits* the translocation of PKC from cytosol to the membrane , the phosphorylation of p38 MAPK , the activation of NF-kappaB , and the expression levels of [TNF-alpha] and IL-6 . Negative_regulation TNF GP2 20499049 2276509 Taken together , the results in this study suggest that CTB *inhibits* the expression of allergic inflammation related cytokines ( [TNF-alpha] and IL-6 ) by blocking NF-kappaB and p38 kinase in BPA induced HMC-1 cells . Negative_regulation TNF GP2 20589743 2345421 We also found that MIL *reduced* the activity of COX-2 and expression of [TNF-a] and IL-1 beta in liver from CCl ( 4 ) -treated mice . Negative_regulation TNF GP2 21268091 2380739 Taken together , the results in this study suggest that GJE *inhibits* the expression of inflammation related cytokines ( [TNF-a] and IL-6 ) in cadmium chloride exposed ICR mice . Negative_regulation TNF GP2 2472279 113662 The secretion of [tumor necrosis factor (TNF)] by human peripheral blood mononuclear cells was *suppressed* by either whole human plasma alpha-globulins or purified alpha <1-acid-glycoprotein> , alpha 1-antitrypsin and alpha 2-macroglobulin in a concentration dependent manner . Negative_regulation TNF GP2 8755512 377389 Binding of thalidomide to alpha1-acid may be *involved* in its inhibition of [tumor necrosis factor] alpha production . Negative_regulation TNF GP5 19214384 2050145 In addition , ZPDC ( 200 microg/ml ) not only diminished the production of superoxide anion , hydrogen peroxide , and nitric oxide , but also *suppressed* the expression of pro-inflammatory cytokines ( IL-1 beta , IL-6 , and [TNF-alpha] ) and proteins ( iNOS , COX-2 , and MMP-9 ) in LPS- stimulated RAW 264.7 cells . Negative_regulation TNF GP5 19885859 2188232 Our results revealed that the CTB in the presence of DEHP *inhibits* the release of histamine and expression of interleukin (IL)-4 , IL-6 , and [TNF-alpha] in RBL-2H3 cells . Negative_regulation TNF GP5 19885859 2188248 The results from these experiments indicated that the CTB *inhibits* release of histamine and expressions of IL-4 , IL-6 , and [TNF-alpha] via down regulations of PKC/MAPK and NF-kappaB on the stage of mast cell degranulation induced by DEHP . Negative_regulation TNF GP5 20499049 2276348 Expression of [TNF-alpha] and IL-6 in HMC-1 cells treated with bisphenol A is *attenuated* by plant originating ( 75 kDa ) by blocking p38 MAPK . Negative_regulation TNF GP5 20499049 2276382 The results obtained from this study revealed that CTB ( 100 microg/ml ) *inhibits* the translocation of PKC from cytosol to the membrane , the phosphorylation of p38 MAPK , the activation of NF-kappaB , and the expression levels of [TNF-alpha] and IL-6 . Negative_regulation TNF GP5 20499049 2276510 Taken together , the results in this study suggest that CTB *inhibits* the expression of allergic inflammation related cytokines ( [TNF-alpha] and IL-6 ) by blocking NF-kappaB and p38 kinase in BPA induced HMC-1 cells . Negative_regulation TNF GP5 20589743 2345422 We also found that MIL *reduced* the activity of COX-2 and expression of [TNF-a] and IL-1 beta in liver from CCl ( 4 ) -treated mice . Negative_regulation TNF GP5 21268091 2380740 Taken together , the results in this study suggest that GJE *inhibits* the expression of inflammation related cytokines ( [TNF-a] and IL-6 ) in cadmium chloride exposed ICR mice . Negative_regulation TNF GP5 2472279 113663 The secretion of [tumor necrosis factor (TNF)] by human peripheral blood mononuclear cells was *suppressed* by either whole human plasma alpha-globulins or purified alpha <1-acid-glycoprotein> , alpha 1-antitrypsin and alpha 2-macroglobulin in a concentration dependent manner . Negative_regulation TNF GP5 8755512 377390 Binding of thalidomide to alpha1-acid may be *involved* in its inhibition of [tumor necrosis factor] alpha production . Negative_regulation TNF GP6 19214384 2050143 In addition , ZPDC ( 200 microg/ml ) not only diminished the production of superoxide anion , hydrogen peroxide , and nitric oxide , but also *suppressed* the expression of pro-inflammatory cytokines ( IL-1 beta , IL-6 , and [TNF-alpha] ) and proteins ( iNOS , COX-2 , and MMP-9 ) in LPS- stimulated RAW 264.7 cells . Negative_regulation TNF GP6 19885859 2188230 Our results revealed that the CTB in the presence of DEHP *inhibits* the release of histamine and expression of interleukin (IL)-4 , IL-6 , and [TNF-alpha] in RBL-2H3 cells . Negative_regulation TNF GP6 19885859 2188246 The results from these experiments indicated that the CTB *inhibits* release of histamine and expressions of IL-4 , IL-6 , and [TNF-alpha] via down regulations of PKC/MAPK and NF-kappaB on the stage of mast cell degranulation induced by DEHP . Negative_regulation TNF GP6 20499049 2276346 Expression of [TNF-alpha] and IL-6 in HMC-1 cells treated with bisphenol A is *attenuated* by plant originating ( 75 kDa ) by blocking p38 MAPK . Negative_regulation TNF GP6 20499049 2276380 The results obtained from this study revealed that CTB ( 100 microg/ml ) *inhibits* the translocation of PKC from cytosol to the membrane , the phosphorylation of p38 MAPK , the activation of NF-kappaB , and the expression levels of [TNF-alpha] and IL-6 . Negative_regulation TNF GP6 20499049 2276508 Taken together , the results in this study suggest that CTB *inhibits* the expression of allergic inflammation related cytokines ( [TNF-alpha] and IL-6 ) by blocking NF-kappaB and p38 kinase in BPA induced HMC-1 cells . Negative_regulation TNF GP6 20589743 2345420 We also found that MIL *reduced* the activity of COX-2 and expression of [TNF-a] and IL-1 beta in liver from CCl ( 4 ) -treated mice . Negative_regulation TNF GP6 21268091 2380738 Taken together , the results in this study suggest that GJE *inhibits* the expression of inflammation related cytokines ( [TNF-a] and IL-6 ) in cadmium chloride exposed ICR mice . Negative_regulation TNF GP6 2472279 113661 The secretion of [tumor necrosis factor (TNF)] by human peripheral blood mononuclear cells was *suppressed* by either whole human plasma alpha-globulins or purified alpha <1-acid-glycoprotein> , alpha 1-antitrypsin and alpha 2-macroglobulin in a concentration dependent manner . Negative_regulation TNF GP6 8755512 377388 Binding of thalidomide to alpha1-acid may be *involved* in its inhibition of [tumor necrosis factor] alpha production . Negative_regulation TNF GP9 19214384 2050146 In addition , ZPDC ( 200 microg/ml ) not only diminished the production of superoxide anion , hydrogen peroxide , and nitric oxide , but also *suppressed* the expression of pro-inflammatory cytokines ( IL-1 beta , IL-6 , and [TNF-alpha] ) and proteins ( iNOS , COX-2 , and MMP-9 ) in LPS- stimulated RAW 264.7 cells . Negative_regulation TNF GP9 19885859 2188233 Our results revealed that the CTB in the presence of DEHP *inhibits* the release of histamine and expression of interleukin (IL)-4 , IL-6 , and [TNF-alpha] in RBL-2H3 cells . Negative_regulation TNF GP9 19885859 2188249 The results from these experiments indicated that the CTB *inhibits* release of histamine and expressions of IL-4 , IL-6 , and [TNF-alpha] via down regulations of PKC/MAPK and NF-kappaB on the stage of mast cell degranulation induced by DEHP . Negative_regulation TNF GP9 20499049 2276349 Expression of [TNF-alpha] and IL-6 in HMC-1 cells treated with bisphenol A is *attenuated* by plant originating ( 75 kDa ) by blocking p38 MAPK . Negative_regulation TNF GP9 20499049 2276383 The results obtained from this study revealed that CTB ( 100 microg/ml ) *inhibits* the translocation of PKC from cytosol to the membrane , the phosphorylation of p38 MAPK , the activation of NF-kappaB , and the expression levels of [TNF-alpha] and IL-6 . Negative_regulation TNF GP9 20499049 2276511 Taken together , the results in this study suggest that CTB *inhibits* the expression of allergic inflammation related cytokines ( [TNF-alpha] and IL-6 ) by blocking NF-kappaB and p38 kinase in BPA induced HMC-1 cells . Negative_regulation TNF GP9 20589743 2345423 We also found that MIL *reduced* the activity of COX-2 and expression of [TNF-a] and IL-1 beta in liver from CCl ( 4 ) -treated mice . Negative_regulation TNF GP9 21268091 2380741 Taken together , the results in this study suggest that GJE *inhibits* the expression of inflammation related cytokines ( [TNF-a] and IL-6 ) in cadmium chloride exposed ICR mice . Negative_regulation TNF GP9 2472279 113664 The secretion of [tumor necrosis factor (TNF)] by human peripheral blood mononuclear cells was *suppressed* by either whole human plasma alpha-globulins or purified alpha <1-acid-glycoprotein> , alpha 1-antitrypsin and alpha 2-macroglobulin in a concentration dependent manner . Negative_regulation TNF GP9 8755512 377391 Binding of thalidomide to alpha1-acid may be *involved* in its inhibition of [tumor necrosis factor] alpha production . Negative_regulation TNF GPC1 21986851 2567855 *attenuated* [TNF-a] , NO , and NADP ( + ) production in macrophages on stimulation with LPS plus IFN-? . Negative_regulation TNF GPC2 21986851 2567856 *attenuated* [TNF-a] , NO , and NADP ( + ) production in macrophages on stimulation with LPS plus IFN-? . Negative_regulation TNF GPC3 21986851 2567857 *attenuated* [TNF-a] , NO , and NADP ( + ) production in macrophages on stimulation with LPS plus IFN-? . Negative_regulation TNF GPC4 21986851 2567858 *attenuated* [TNF-a] , NO , and NADP ( + ) production in macrophages on stimulation with LPS plus IFN-? . Negative_regulation TNF GPC5 21986851 2567859 *attenuated* [TNF-a] , NO , and NADP ( + ) production in macrophages on stimulation with LPS plus IFN-? . Negative_regulation TNF GPC6 21986851 2567860 *attenuated* [TNF-a] , NO , and NADP ( + ) production in macrophages on stimulation with LPS plus IFN-? . Negative_regulation TNF GPI 20551909 2308530 In vitro Ad-HO-1 M showed an anti-inflammatory phenotype with increased phagocytosis of apoptotic cells (ACs) and increased interleukin (IL)-10 but *reduced* [TNF-alpha] and nitric oxide ( NO ) following lipopolysaccharide/interferon-gamma (IFN gamma) stimulation compared to control transduced or unmodified M phi . Negative_regulation TNF GPI 21826646 2599165 Low dose effectively *inhibited* the [tumor necrosis factor-a (TNF-a)-] or the interleukin-1ß (IL-1ß) induced production of ICAM-1 in human umbilical vascular endothelial cells ( HUVECs ) . Negative_regulation TNF GPI 7591712 334263 In the presence of 100 microM phloretin or DIDS the of activated monocyte was reduced to control value , [TNF-alpha] production was *inhibited* completely and total protein synthesis was inhibited by 61 % . Negative_regulation TNF GPI 8022853 263160 We conclude that LPS stimulation of hp-M from liver disease *results* in similar production of IL-1 beta , IL-6 and [TNF-alpha] , but that the profile of the eicosanoid production of these M phi stimulated with LPS and A23187 differs from M phi of other origin and species . Negative_regulation TNF GPI 8660797 364998 C3H-PM treated with C1q or Lipid A displayed increased TNF-R mRNA synthesis and in combination with Lipid A and anti-C1q antibody *inhibited* [TNF-R] and nitric oxide synthase (NOS) mRNA synthesis compared with Lipid A only , but had no effect on TNF mRNA synthesis . Negative_regulation TNF GPR15 22047069 2513883 Here , we report novel strategies for successfully retargeting BoNTs , and also tetanus neurotoxin ( TeNT ) , to primary human blood monocyte derived macrophages where *inhibited* the release of [tumor necrosis factor-a] , a cytokine that plays a key role in inflammation . Negative_regulation TNF GPX1 19394397 2089414 Consistently , CAPE normalized the activity of GR , , SOD and CAT , *inhibited* the rise in [TNF-alpha] and ameliorated the histopathological changes . Negative_regulation TNF GPX2 19394397 2089415 Consistently , CAPE normalized the activity of GR , , SOD and CAT , *inhibited* the rise in [TNF-alpha] and ameliorated the histopathological changes . Negative_regulation TNF GPX3 19394397 2089416 Consistently , CAPE normalized the activity of GR , , SOD and CAT , *inhibited* the rise in [TNF-alpha] and ameliorated the histopathological changes . Negative_regulation TNF GPX4 19394397 2089417 Consistently , CAPE normalized the activity of GR , , SOD and CAT , *inhibited* the rise in [TNF-alpha] and ameliorated the histopathological changes . Negative_regulation TNF GPX5 19394397 2089418 Consistently , CAPE normalized the activity of GR , , SOD and CAT , *inhibited* the rise in [TNF-alpha] and ameliorated the histopathological changes . Negative_regulation TNF GPX6 19394397 2089419 Consistently , CAPE normalized the activity of GR , , SOD and CAT , *inhibited* the rise in [TNF-alpha] and ameliorated the histopathological changes . Negative_regulation TNF GPX7 19394397 2089420 Consistently , CAPE normalized the activity of GR , , SOD and CAT , *inhibited* the rise in [TNF-alpha] and ameliorated the histopathological changes . Negative_regulation TNF GPX8 19394397 2089413 Consistently , CAPE normalized the activity of GR , , SOD and CAT , *inhibited* the rise in [TNF-alpha] and ameliorated the histopathological changes . Negative_regulation TNF GRAP2 10734180 679178 A role for p38 kinase in cytokine associated inflammation in the mouse was shown by activation in the lung and *inhibition* of lipopolysaccharide induced [tumor necrosis factor-alpha] production by SB 239063 ( ED ( 50 ) = 5.8 mg/kg p.o. ) . Negative_regulation TNF GRAP2 11299196 803213 SB203580 inhibited MAPK activity , *reduced* myocyte secretion of [TNF-alpha] , and prevented burn mediated cardiac deficits . Negative_regulation TNF GRAP2 11500933 847143 Treatment of the cells with TNF-alpha alone had little effect on their viability , but they became very sensitive to apoptosis when treated with [TNF-alpha] in the *presence* of the inhibitor SB 203580 . Negative_regulation TNF GRAP2 12464556 1022200 Also for SB 202190 this correlation in inhibition of IL-1beta and [TNFalpha] synthesis ( IC ( 50 ) 's : 0.055 microM and 1.01 microM ) and kinase *inhibition* ( IC ( 50 ) : 0.088 microM ) could be shown . Negative_regulation TNF GRAP2 12559181 1052099 It was concluded that pretranscriptional regulation of [TNF] gene expression in Kupffer cells *follows* an orderly activation of , ERK1/2 , and SAPK/JNK that may not converge on NF-kappaB . Negative_regulation TNF GRAP2 12867362 1149940 JNK mainly regulates TNF-alpha transcription and apoptosis , whereas ERK and *contribute* to the regulation of [TNF-alpha] production , probably through posttranscriptional mechanisms . Negative_regulation TNF GRAP2 15519192 1328818 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial [TNFalpha] mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as TNFalpha production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* MAPK activation . Negative_regulation TNF GRAP2 16081599 1460325 PD98059 , U0126 ) and ( SB202190 , PD169316 ) *inhibited* the secretion of [TNF-alpha] . Negative_regulation TNF GRAP2 16207331 1464311 In vivo , overexpression of [TNF] *induced* activation of and ERK in the synovial membrane , whereas activation of JNK was less pronounced and rarely observed on immunohistochemical analysis . Negative_regulation TNF GRAP2 16269458 1509292 An inhibitor of activation ( SB203580 ) *had* no effect on [TNFalpha-] or IL-1beta stimulated PAPP-A expression . Negative_regulation TNF GRAP2 18559343 1952536 OxPAPC inhibited [tumor necrosis factor-alpha] production , IkappaBalpha degradation , MAPK phosphorylation , and NF-kappaB dependent reporter activation *induced* by stimulants of TLR2 and TLR4 ( Pam3CSK4 and LPS ) but not by stimulants of other TLRs ( poly ( I.C ) , flagellin , loxoribine , single stranded RNA , or CpG DNA ) in macrophages and HEK-293 cells transfected with respective TLRs and significantly reduced inflammatory responses in mice injected subcutaneously or intraperitoneally with Pam3CSK4 . Negative_regulation TNF GRAP2 21042558 2344363 Genistein represses the release of [TNF-a] and significantly *inhibits* ERK and phosphorylation in activated microglial cells by acting as a tyrosine kinase inhibitor . Negative_regulation TNF GRAP2 21314908 2393321 Administration of an inhibitor specific to p38 or JNK resulted in varying degrees of attenuation on ApxI induced cytokine expression , suggesting the differential regulatory *roles* of and JNK in IL-1ß , IL-8 and [TNF-a] production . Negative_regulation TNF GRAP2 22198506 2558713 MKP1 attenuates ERK1/2 and activation , *inhibits* myocardial [TNF-a] expression , and improves cardiac function in endotoxemia . Negative_regulation TNF GRAP2 22418033 2582632 Danshensu partly blocked the expression of RAGE , , and COX-2 , and NF-?B activation , and *inhibited* the increase of [TNF-a] , IL-6 , and PGE2 . Negative_regulation TNF GRAP2 23258237 2741341 [TNF-a] specifically activated p38a but not other p38 isoforms and suppression of by an siRNA *resulted* in further amplification of the TNF-a effect . Negative_regulation TNF GRAP2 24304472 2904834 In endotoxaemic mice , PE promoted myocardial ERK1/2 phosphorylation and c-Fos expression , *inhibited* phosphorylation and I?Ba degradation , reduced myocardial [TNF-a] production and prevented LPS provoked cardiac dysfunction . Negative_regulation TNF GRAP2 9177222 434133 Wortmannin , an inhibitor of phosphatidylinositol 3-kinase , diminished FcepsilonRI mediated [TNF-alpha] synthesis , significantly blunted JNK activation and TNF-alpha promoter-driven luciferase expression , and only weakly *inhibited* kinase activation . Negative_regulation TNF GRB10 17673143 1777233 significantly *inhibited* [TNF-alpha] upregulation in PBMCs , FLS and chondrocytes induced by IFN-gamma , LPS or IL-1 . Negative_regulation TNF GRB14 17673143 1777234 significantly *inhibited* [TNF-alpha] upregulation in PBMCs , FLS and chondrocytes induced by IFN-gamma , LPS or IL-1 . Negative_regulation TNF GRB2 17673143 1777235 significantly *inhibited* [TNF-alpha] upregulation in PBMCs , FLS and chondrocytes induced by IFN-gamma , LPS or IL-1 . Negative_regulation TNF GRB7 17673143 1777236 significantly *inhibited* [TNF-alpha] upregulation in PBMCs , FLS and chondrocytes induced by IFN-gamma , LPS or IL-1 . Negative_regulation TNF GREM1 24003215 2862183 binds with high affinity to MIF ( KD = 54 nm ) , as evidenced by surface plasmon resonance analysis and co-immunoprecipitation , and *reduces* MIF induced release of [TNF-a] from macrophages . Negative_regulation TNF GRP 8982099 403813 On the contrary , and VIP *inhibited* highly the LPS induced [TNF alpha] production in young controls . Negative_regulation TNF GSK3B 18027881 1894623 This study was to investigate the *role* of ( GSK-3beta ) in cardiomyocyte [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Negative_regulation TNF GSK3B 18027881 1894626 Inhibition of by SB216763 or by over-expression of a dominant negative mutant of GSK-3beta significantly *enhanced* [TNF-alpha] expression in LPS stimulated cardiomyocytes , in association with an increase in p65 phosphorylation . Negative_regulation TNF GSK3B 18027881 1894627 In contrast , over-expression of by adenoviral vectors containing wild-type GSK-3beta or a constitutively active GSK-3beta *attenuated* [TNF-alpha] expression induced by LPS . Negative_regulation TNF GSK3B 18027881 1894628 Further evidence to support the inhibitory *role* of in [TNF-alpha] expression is that protein kinase B ( Akt ) signaling , an upstream inhibitor of GSK-3beta , promotes TNF-alpha expression in LPS stimulated cardiomyocytes and this action of Akt signaling can be mimicked by GSK-3beta inactivation . Negative_regulation TNF GSK3B 19596777 2122944 Heat inactivated S. aureus activated , and *inhibiting* GSK-3beta reduced [TNF-alpha] production as well as inducible NO synthase (iNOS)/NO biosynthesis . Negative_regulation TNF GSN 19110227 2031713 is present in midtrimester amniotic fluid , binds to LPS , and *inhibits* the induction of [TNF-alpha] . Negative_regulation TNF GSTM1 11407310 825853 stimulated spontaneous TNF-alpha production and *inhibited* LPS stimulated [TNF-alpha] production in 16 of 24 ( 75 % ) individuals of LPS-responsive group and one of six individuals ( 17 % ) of LPS-non-responsive group . Negative_regulation TNF GSTM1 11407310 825858 We conclude that there is a heterogeneity among normal population for TNF-alpha production in response to LPS , and *inhibits* LPS stimulated [TNF-alpha] production , primarily in LPS responders . Negative_regulation TNF GSTM1 12473262 1023175 Thus , we for the first time report that *inhibits* LPS stimulated [TNF-alpha] production through ceramide pathway and anti-inflammatory activity of GSTM in treatment of RA may depend on its ability to inhibit NF-kappaB activation and TNF-alpha production . Negative_regulation TNF GSTM1 9278181 450833 These data indicate that can *inhibit* [TNF alpha] production when the PBMC are preactivated by LPS . Negative_regulation TNF GSTM2 11407310 825854 stimulated spontaneous TNF-alpha production and *inhibited* LPS stimulated [TNF-alpha] production in 16 of 24 ( 75 % ) individuals of LPS-responsive group and one of six individuals ( 17 % ) of LPS-non-responsive group . Negative_regulation TNF GSTM2 11407310 825859 We conclude that there is a heterogeneity among normal population for TNF-alpha production in response to LPS , and *inhibits* LPS stimulated [TNF-alpha] production , primarily in LPS responders . Negative_regulation TNF GSTM2 12473262 1023176 Thus , we for the first time report that *inhibits* LPS stimulated [TNF-alpha] production through ceramide pathway and anti-inflammatory activity of GSTM in treatment of RA may depend on its ability to inhibit NF-kappaB activation and TNF-alpha production . Negative_regulation TNF GSTM2 9278181 450834 These data indicate that can *inhibit* [TNF alpha] production when the PBMC are preactivated by LPS . Negative_regulation TNF GSTM3 11407310 825855 stimulated spontaneous TNF-alpha production and *inhibited* LPS stimulated [TNF-alpha] production in 16 of 24 ( 75 % ) individuals of LPS-responsive group and one of six individuals ( 17 % ) of LPS-non-responsive group . Negative_regulation TNF GSTM3 11407310 825860 We conclude that there is a heterogeneity among normal population for TNF-alpha production in response to LPS , and *inhibits* LPS stimulated [TNF-alpha] production , primarily in LPS responders . Negative_regulation TNF GSTM3 12473262 1023177 Thus , we for the first time report that *inhibits* LPS stimulated [TNF-alpha] production through ceramide pathway and anti-inflammatory activity of GSTM in treatment of RA may depend on its ability to inhibit NF-kappaB activation and TNF-alpha production . Negative_regulation TNF GSTM3 9278181 450835 These data indicate that can *inhibit* [TNF alpha] production when the PBMC are preactivated by LPS . Negative_regulation TNF GSTM4 11407310 825856 stimulated spontaneous TNF-alpha production and *inhibited* LPS stimulated [TNF-alpha] production in 16 of 24 ( 75 % ) individuals of LPS-responsive group and one of six individuals ( 17 % ) of LPS-non-responsive group . Negative_regulation TNF GSTM4 11407310 825861 We conclude that there is a heterogeneity among normal population for TNF-alpha production in response to LPS , and *inhibits* LPS stimulated [TNF-alpha] production , primarily in LPS responders . Negative_regulation TNF GSTM4 12473262 1023178 Thus , we for the first time report that *inhibits* LPS stimulated [TNF-alpha] production through ceramide pathway and anti-inflammatory activity of GSTM in treatment of RA may depend on its ability to inhibit NF-kappaB activation and TNF-alpha production . Negative_regulation TNF GSTM4 9278181 450836 These data indicate that can *inhibit* [TNF alpha] production when the PBMC are preactivated by LPS . Negative_regulation TNF GSTM5 11407310 825857 stimulated spontaneous TNF-alpha production and *inhibited* LPS stimulated [TNF-alpha] production in 16 of 24 ( 75 % ) individuals of LPS-responsive group and one of six individuals ( 17 % ) of LPS-non-responsive group . Negative_regulation TNF GSTM5 11407310 825862 We conclude that there is a heterogeneity among normal population for TNF-alpha production in response to LPS , and *inhibits* LPS stimulated [TNF-alpha] production , primarily in LPS responders . Negative_regulation TNF GSTM5 12473262 1023179 Thus , we for the first time report that *inhibits* LPS stimulated [TNF-alpha] production through ceramide pathway and anti-inflammatory activity of GSTM in treatment of RA may depend on its ability to inhibit NF-kappaB activation and TNF-alpha production . Negative_regulation TNF GSTM5 9278181 450837 These data indicate that can *inhibit* [TNF alpha] production when the PBMC are preactivated by LPS . Negative_regulation TNF GSTP1 18962899 2028840 Meanwhile , *prevented* LPS induced [TNF-alpha] , IL-1beta , MCP-1 and NO production . Negative_regulation TNF GTS 17334244 1720084 ( 4 mg/kg ) significantly *inhibited* serum [tumor necrosis factor] during endotoxemia and improved survival ( p < .0001 ) . Negative_regulation TNF GTS 17414429 1722543 strongly *inhibited* LPS induced [TNF-alpha] release into the peritoneal cavity and the circulation . Negative_regulation TNF GTS 17621262 1822149 dose-dependently *inhibited* LPS induced [TNF-alpha] release by MH-S mouse alveolar macrophages in vitro . Negative_regulation TNF GTS 19593403 2105344 Furthermore , *attenuated* [TNF] production in monocytes stimulated with peptidoglycan , polyinosinic-polycytidylic acid , CpG , HMGB1 ( high-mobility group box 1 protein ) , and advanced glycation end product modified albumin . Negative_regulation TNF GTS 19602049 2180229 Unlike non-specific nicotinic agonists , *inhibited* serum protein [TNF] levels in both normal and splenectomized , haemorrhagic animals . Negative_regulation TNF GUCY2F 16199883 1463495 *represses* [tumor necrosis factor] alpha expression . Negative_regulation TNF H6PD 8170501 255192 To investigate one of the possible mechanisms of the TNF alpha induced decrease of PIP2 formation , the effect of TNF alpha pretreatment on glycerol-3-phosphate dehydrogenase (GDH) , a key enzyme of lipogenesis , was studied : Exposure of the rat cardiomyocytes for 72 h to [TNF alpha] *induced* a concentration dependent decrease in activity by maximally 55 % . Negative_regulation TNF HCL1 11682062 873999 Luciferase gene reporter assays revealed that cPrG . potently *suppressed* the [TNFalpha-] and the phorbol myristate acetate induced activation of NF-kappaB . Negative_regulation TNF HCL1 17827742 1791580 cPrG . *inhibited* neither [TNFalpha-] or PMA induced DNA binding of AP-1 nor co-activator p300 induced activation of AP-1 . Negative_regulation TNF HCL1 20093129 2212758 and GlcNAc significantly *suppressed* the antigen induced up-regulation of [TNF-alpha] and IL-6 mRNA . Negative_regulation TNF HCL2 11682062 874000 Luciferase gene reporter assays revealed that cPrG . potently *suppressed* the [TNFalpha-] and the phorbol myristate acetate induced activation of NF-kappaB . Negative_regulation TNF HCL2 17827742 1791581 cPrG . *inhibited* neither [TNFalpha-] or PMA induced DNA binding of AP-1 nor co-activator p300 induced activation of AP-1 . Negative_regulation TNF HCL2 20093129 2212759 and GlcNAc significantly *suppressed* the antigen induced up-regulation of [TNF-alpha] and IL-6 mRNA . Negative_regulation TNF HCL3 11682062 874001 Luciferase gene reporter assays revealed that cPrG . potently *suppressed* the [TNFalpha-] and the phorbol myristate acetate induced activation of NF-kappaB . Negative_regulation TNF HCL3 17827742 1791582 cPrG . *inhibited* neither [TNFalpha-] or PMA induced DNA binding of AP-1 nor co-activator p300 induced activation of AP-1 . Negative_regulation TNF HCL3 20093129 2212760 and GlcNAc significantly *suppressed* the antigen induced up-regulation of [TNF-alpha] and IL-6 mRNA . Negative_regulation TNF HDAC1 15743782 1378964 We provide experimental evidence that the inappropriate expression of TNF-alpha by nfkappab1 ( -/- ) cells is because of lack of a p50 dependent *mediated* repression of [TNF-alpha] gene transcription . Negative_regulation TNF HES1 15133244 1245712 In addition , markedly *suppressed* plasma levels of [TNF-alpha] and high mobility group box chromosomal protein 1 ( HMGB-1 ) , decreased the number of apoptotic cells in livers and normalized the activated states of blood coagulation factors such as prothrombin time and platelet numbers caused by infection . Negative_regulation TNF HES1 15836676 1397661 significantly *reduced* the increased hepatic levels of [TNF-alpha] , IL-1beta , IL-6 , IL-8 and the mRNAs in the endotoxemic rats . Negative_regulation TNF HES1 16104441 1444698 significantly *reduced* the LPS induced increase in intestinal levels of [TNF-alpha] , IL-1beta , IL-6 , IL-8 and their corresponding mRNAs . Negative_regulation TNF HES1 16790644 1578625 significantly *reduced* the increased intestinal levels of [tumor necrosis factor-alpha] , IL-6 , cytokine induced neutrophil chemoattractant-1 , and the mRNAs in the endotoxemic rats . Negative_regulation TNF HES1 19166983 2038545 In addition , both and BL could *attenuate* the increase in [TNF-alpha] , IL-6 , MPO levels and NF-kappaB activation . Negative_regulation TNF HES1 19766237 2224567 dose-dependently *reduced* the plasma level of [TNF-alpha] and IL-6 in rats with sepsis . Negative_regulation TNF HES1 20451670 2288420 Meanwhile , could significantly *reduce* [TNF-alpha] , IL-6 , and ICAM-1 mRNA , inhibit NF-kappaB activation , and down-regulate TLR2 and TLR4 expression in the brain . Negative_regulation TNF HES2 15133244 1245707 In addition , markedly *suppressed* plasma levels of [TNF-alpha] and high mobility group box chromosomal protein 1 ( HMGB-1 ) , decreased the number of apoptotic cells in livers and normalized the activated states of blood coagulation factors such as prothrombin time and platelet numbers caused by infection . Negative_regulation TNF HES2 15836676 1397656 significantly *reduced* the increased hepatic levels of [TNF-alpha] , IL-1beta , IL-6 , IL-8 and the mRNAs in the endotoxemic rats . Negative_regulation TNF HES2 16104441 1444693 significantly *reduced* the LPS induced increase in intestinal levels of [TNF-alpha] , IL-1beta , IL-6 , IL-8 and their corresponding mRNAs . Negative_regulation TNF HES2 16790644 1578620 significantly *reduced* the increased intestinal levels of [tumor necrosis factor-alpha] , IL-6 , cytokine induced neutrophil chemoattractant-1 , and the mRNAs in the endotoxemic rats . Negative_regulation TNF HES2 19166983 2038540 In addition , both and BL could *attenuate* the increase in [TNF-alpha] , IL-6 , MPO levels and NF-kappaB activation . Negative_regulation TNF HES2 19766237 2224562 dose-dependently *reduced* the plasma level of [TNF-alpha] and IL-6 in rats with sepsis . Negative_regulation TNF HES2 20451670 2288415 Meanwhile , could significantly *reduce* [TNF-alpha] , IL-6 , and ICAM-1 mRNA , inhibit NF-kappaB activation , and down-regulate TLR2 and TLR4 expression in the brain . Negative_regulation TNF HES3 15133244 1245711 In addition , markedly *suppressed* plasma levels of [TNF-alpha] and high mobility group box chromosomal protein 1 ( HMGB-1 ) , decreased the number of apoptotic cells in livers and normalized the activated states of blood coagulation factors such as prothrombin time and platelet numbers caused by infection . Negative_regulation TNF HES3 15836676 1397660 significantly *reduced* the increased hepatic levels of [TNF-alpha] , IL-1beta , IL-6 , IL-8 and the mRNAs in the endotoxemic rats . Negative_regulation TNF HES3 16104441 1444697 significantly *reduced* the LPS induced increase in intestinal levels of [TNF-alpha] , IL-1beta , IL-6 , IL-8 and their corresponding mRNAs . Negative_regulation TNF HES3 16790644 1578624 significantly *reduced* the increased intestinal levels of [tumor necrosis factor-alpha] , IL-6 , cytokine induced neutrophil chemoattractant-1 , and the mRNAs in the endotoxemic rats . Negative_regulation TNF HES3 19166983 2038544 In addition , both and BL could *attenuate* the increase in [TNF-alpha] , IL-6 , MPO levels and NF-kappaB activation . Negative_regulation TNF HES3 19766237 2224566 dose-dependently *reduced* the plasma level of [TNF-alpha] and IL-6 in rats with sepsis . Negative_regulation TNF HES3 20451670 2288419 Meanwhile , could significantly *reduce* [TNF-alpha] , IL-6 , and ICAM-1 mRNA , inhibit NF-kappaB activation , and down-regulate TLR2 and TLR4 expression in the brain . Negative_regulation TNF HES4 15133244 1245710 In addition , markedly *suppressed* plasma levels of [TNF-alpha] and high mobility group box chromosomal protein 1 ( HMGB-1 ) , decreased the number of apoptotic cells in livers and normalized the activated states of blood coagulation factors such as prothrombin time and platelet numbers caused by infection . Negative_regulation TNF HES4 15836676 1397659 significantly *reduced* the increased hepatic levels of [TNF-alpha] , IL-1beta , IL-6 , IL-8 and the mRNAs in the endotoxemic rats . Negative_regulation TNF HES4 16104441 1444696 significantly *reduced* the LPS induced increase in intestinal levels of [TNF-alpha] , IL-1beta , IL-6 , IL-8 and their corresponding mRNAs . Negative_regulation TNF HES4 16790644 1578623 significantly *reduced* the increased intestinal levels of [tumor necrosis factor-alpha] , IL-6 , cytokine induced neutrophil chemoattractant-1 , and the mRNAs in the endotoxemic rats . Negative_regulation TNF HES4 19166983 2038543 In addition , both and BL could *attenuate* the increase in [TNF-alpha] , IL-6 , MPO levels and NF-kappaB activation . Negative_regulation TNF HES4 19766237 2224565 dose-dependently *reduced* the plasma level of [TNF-alpha] and IL-6 in rats with sepsis . Negative_regulation TNF HES4 20451670 2288418 Meanwhile , could significantly *reduce* [TNF-alpha] , IL-6 , and ICAM-1 mRNA , inhibit NF-kappaB activation , and down-regulate TLR2 and TLR4 expression in the brain . Negative_regulation TNF HES5 15133244 1245709 In addition , markedly *suppressed* plasma levels of [TNF-alpha] and high mobility group box chromosomal protein 1 ( HMGB-1 ) , decreased the number of apoptotic cells in livers and normalized the activated states of blood coagulation factors such as prothrombin time and platelet numbers caused by infection . Negative_regulation TNF HES5 15836676 1397658 significantly *reduced* the increased hepatic levels of [TNF-alpha] , IL-1beta , IL-6 , IL-8 and the mRNAs in the endotoxemic rats . Negative_regulation TNF HES5 16104441 1444695 significantly *reduced* the LPS induced increase in intestinal levels of [TNF-alpha] , IL-1beta , IL-6 , IL-8 and their corresponding mRNAs . Negative_regulation TNF HES5 16790644 1578622 significantly *reduced* the increased intestinal levels of [tumor necrosis factor-alpha] , IL-6 , cytokine induced neutrophil chemoattractant-1 , and the mRNAs in the endotoxemic rats . Negative_regulation TNF HES5 19166983 2038542 In addition , both and BL could *attenuate* the increase in [TNF-alpha] , IL-6 , MPO levels and NF-kappaB activation . Negative_regulation TNF HES5 19766237 2224564 dose-dependently *reduced* the plasma level of [TNF-alpha] and IL-6 in rats with sepsis . Negative_regulation TNF HES5 20451670 2288417 Meanwhile , could significantly *reduce* [TNF-alpha] , IL-6 , and ICAM-1 mRNA , inhibit NF-kappaB activation , and down-regulate TLR2 and TLR4 expression in the brain . Negative_regulation TNF HES6 15133244 1245708 In addition , markedly *suppressed* plasma levels of [TNF-alpha] and high mobility group box chromosomal protein 1 ( HMGB-1 ) , decreased the number of apoptotic cells in livers and normalized the activated states of blood coagulation factors such as prothrombin time and platelet numbers caused by infection . Negative_regulation TNF HES6 15836676 1397657 significantly *reduced* the increased hepatic levels of [TNF-alpha] , IL-1beta , IL-6 , IL-8 and the mRNAs in the endotoxemic rats . Negative_regulation TNF HES6 16104441 1444694 significantly *reduced* the LPS induced increase in intestinal levels of [TNF-alpha] , IL-1beta , IL-6 , IL-8 and their corresponding mRNAs . Negative_regulation TNF HES6 16790644 1578621 significantly *reduced* the increased intestinal levels of [tumor necrosis factor-alpha] , IL-6 , cytokine induced neutrophil chemoattractant-1 , and the mRNAs in the endotoxemic rats . Negative_regulation TNF HES6 19166983 2038541 In addition , both and BL could *attenuate* the increase in [TNF-alpha] , IL-6 , MPO levels and NF-kappaB activation . Negative_regulation TNF HES6 19766237 2224563 dose-dependently *reduced* the plasma level of [TNF-alpha] and IL-6 in rats with sepsis . Negative_regulation TNF HES6 20451670 2288416 Meanwhile , could significantly *reduce* [TNF-alpha] , IL-6 , and ICAM-1 mRNA , inhibit NF-kappaB activation , and down-regulate TLR2 and TLR4 expression in the brain . Negative_regulation TNF HES7 15133244 1245706 In addition , markedly *suppressed* plasma levels of [TNF-alpha] and high mobility group box chromosomal protein 1 ( HMGB-1 ) , decreased the number of apoptotic cells in livers and normalized the activated states of blood coagulation factors such as prothrombin time and platelet numbers caused by infection . Negative_regulation TNF HES7 15836676 1397655 significantly *reduced* the increased hepatic levels of [TNF-alpha] , IL-1beta , IL-6 , IL-8 and the mRNAs in the endotoxemic rats . Negative_regulation TNF HES7 16104441 1444692 significantly *reduced* the LPS induced increase in intestinal levels of [TNF-alpha] , IL-1beta , IL-6 , IL-8 and their corresponding mRNAs . Negative_regulation TNF HES7 16790644 1578619 significantly *reduced* the increased intestinal levels of [tumor necrosis factor-alpha] , IL-6 , cytokine induced neutrophil chemoattractant-1 , and the mRNAs in the endotoxemic rats . Negative_regulation TNF HES7 19166983 2038539 In addition , both and BL could *attenuate* the increase in [TNF-alpha] , IL-6 , MPO levels and NF-kappaB activation . Negative_regulation TNF HES7 19766237 2224561 dose-dependently *reduced* the plasma level of [TNF-alpha] and IL-6 in rats with sepsis . Negative_regulation TNF HES7 20451670 2288414 Meanwhile , could significantly *reduce* [TNF-alpha] , IL-6 , and ICAM-1 mRNA , inhibit NF-kappaB activation , and down-regulate TLR2 and TLR4 expression in the brain . Negative_regulation TNF HFE 1558977 184589 We conclude that release of [TNF-alpha] by monocytes may be selectively *impaired* in hereditary . Negative_regulation TNF HFE 23176387 2707689 The results show that significantly *inhibited* the release of pro-inflammatory cytokines such as [TNF-a] and IL-1ß . Negative_regulation TNF HGF 11390418 822461 also markedly *suppressed* IFN-gamma and [TNF-alpha] expression in the intestine and liver and decreased the serum IL-12 . Negative_regulation TNF HGF 23458413 2760570 could *reduce* secretion and expression of proinflammatory cytokines , including [tumor necrosis factor-a] , interferon-? , interleukin (IL)-6 , and intercellular adhesion molecule-1 , and increase the expression of antiinflammatory cytokine IL-10 . Negative_regulation TNF HHIP 22419609 2668915 Ectopic expression of *resulted* in attenuation of oxidative damage , reduction of [TNF-a] and IL-6 expression , and elevation of epithelial proliferation in colonic mucosa and led to decreased apoptosis and increased proliferation in colonic adenocarcinoma cells . Negative_regulation TNF HIST1H1E 10779788 687518 Furthermore , not only *reduced* peak serum levels of [TNF-alpha] of mice when preinjected but also reduced TNF-alpha levels when given 15 min after the endotoxin challenge . Negative_regulation TNF HIST2H2AC 12667084 1075191 In the *presence* of the binding of LPS to the macrophage cell line RAW 264.7 , and the LPS induced production of [TNF-alpha] and nitric oxide by these cells , were markedly reduced . Negative_regulation TNF HMGB1 19158276 2043326 Depletion of by small interfering RNA results in dissociation of RelB from the promoter and partially *restores* [TNF-alpha] transcription . Negative_regulation TNF HMGB1 22258232 2579999 Honokiol significantly *reduced* the increases in serum [tumor necrosis factor-a] , interleukin 1 , and nitric oxide levels 3 h and serum 24 h after acute pancreatitis induction . Negative_regulation TNF HMGB1 22459482 2612911 Real-time PCR showed that in postnatal 4 months , db/db mice *induced* significant increases of [TNF-alpha] , IL-1ß , IL-6 and monocyte chemoattractant protein-1 ( MCP-1 ) in the spinal dorsal horn , while ( 50 µg ) effectively inhibited the up-regulation of these inflammatory mediators . Negative_regulation TNF HMGB1 24361371 2905561 The complex *reduced* the levels of IL-6 and [TNF-a] more efficiently than HMGB1A only or siS1PLyase/R3V6 complex in the LPS activated macrophage cells . Negative_regulation TNF HMGCR 15936988 1440448 Simvastatin , an inhibitor with mild inhibition of LFA-1 , *induced* the production of interleukin (IL)-18 , [tumor necrosis factor (TNF)-alpha] and interferon (IFN)-gamma in human peripheral blood mononuclear cells ( PBMC ) . Negative_regulation TNF HMHA1 1431255 202876 should prevent death in endotoxemic patients and *reduce* serum levels of [TNF] and interleukin-6 (IL-6) . Negative_regulation TNF HMOX1 16888021 1596853 In LPS challenged mice in vivo , both acute alcohol administration and activation augmented IL-10 and *inhibited* [TNF-alpha] serum levels . Negative_regulation TNF HMOX1 17234154 1689551 *inhibited* anti-OA serum/OA induced IL-3 and [TNF-alpha] production . Negative_regulation TNF HMOX1 17234154 1689553 Inhibition of activity by Zn ( II ) protoporphyrin IX , a specific HO-1 inhibitor , *prevented* the suppression of [TNF-alpha] production . Negative_regulation TNF HMOX1 17883332 1818640 Selective expression of *prevented* [TNF-] and hyperglycemia mediated superoxide ( O2- ) formation , DNA degeneration , and upregulation of caspase , but increased the expression of pAkt and Bcl-xL , proteins responsible for endothelial dysfunction in diabetes . Negative_regulation TNF HMOX1 18210237 1839090 Costunolide *inhibits* production of [tumor necrosis factor-alpha] and interleukin-6 by inducing in RAW264.7 macrophages . Negative_regulation TNF HMOX1 18442782 1900624 upregulation significantly *inhibits* [TNF-alpha] and Hmgb1 releasing and attenuates lipopolysaccharide induced acute lung injury in mice . Negative_regulation TNF HMOX1 19885007 2161005 We examined our hypothesis whether inhibitory effects of aprotinin on cytokine induced inducible nitric oxide synthase (iNOS) expression ( IL-1beta plus [TNF-alpha] ) , reactive oxygen species ( ROS ) generation , and vascular smooth muscle cell ( VSMC ) proliferation were *due* to induction in rat VSMCs . Negative_regulation TNF HMOX1 21083424 2424798 In addition , is *required* for nicotine mediated suppression of [tumor necrosis factor-a] , inducible nitric oxide synthase , and high mobility group box 1 expression induced by LPS in macrophages , as evidenced by the fact that nicotine failed to inhibit production of these mediators when HO-1 was suppressed . Negative_regulation TNF HMOX1 21946119 2525144 Consequently , inhibited the activation , proliferation , and T helper 1 polarization of liver infiltrating CD4+ T cells and *reduced* the production of serum alanine aminotransferase and proinflammatory cytokines such as interferon-? and [tumor necrosis factor-a] . Negative_regulation TNF HMOX1 22461696 2583146 Furthermore , upregulation of by cobalt protoporphyrin IX *diminished* the production of [TNF-a] and reactive oxygen species by infected murine macrophages and increased Cu/Zn superoxide dismutase expression in human monocytes . Negative_regulation TNF HMOX1 22609006 2632296 Keap1 knockdown also *inhibited* endotoxin induced expression of inducible nitric oxide synthase (iNOS) and [TNF-a] by upregulating , GCL , and Prx1 expression in macrophages . Negative_regulation TNF HMOX1 23423194 2755340 *Role* of in [TNF/TNF] receptor mediated apoptosis after hepatic ischemia/reperfusion in rats . Negative_regulation TNF HMOX1 23423194 2755346 Our findings suggest that the cytoprotective effects of are *mediated* by suppression of [TNF/TNFR1] mediated apoptotic signaling , specifically by modulating apoptotic DISC formation and mitochondrial TNFR1 translocation during hepatic I/R . Negative_regulation TNF HMOX1 23939022 2916013 These effects were mediated by upregulating the expression of and *inhibiting* the production of IL-1ß and [TNF-a] in intestinal macrophages . Negative_regulation TNF HMOX1 24095726 2878801 In an LPS induced endotoxemia model , deficiency *blocked* the effects of nicotine on the STAT3 phosphorylation , TTP induction , and LPS induced [TNF-a] production in the liver . Negative_regulation TNF HMOX1 25302050 2959322 Inhibition of in these cells *increased* the expression of IFN-? and [TNF-a] in CD107a + NK-92 cells . Negative_regulation TNF HMOX1 25302050 2959323 Inhibition of in CCC *induces* an increase in IFN-? and [TNF-a] production in CD107a + NK-92 cells and restores NKG2D , NKp46 and NKp30 downmodulation in NK cells . Negative_regulation TNF HNRNPD 21733716 2483986 Knockdown mRNA expression by AUF1 siRNA in MKP-1 WT bone marrow macrophages significantly *delayed* degradation of IL-6 , IL-10 and [TNF-] a mRNAs compared with controls . Negative_regulation TNF HNRNPF 21885868 2496469 Targeting and ATMs with curcusomes in ob/ob mice reduced NF-?B/RelA DNA binding activity , *reduced* [TNF] , and enhanced interleukin-4 production . Negative_regulation TNF HNRNPH1 21885868 2496470 Targeting and ATMs with curcusomes in ob/ob mice reduced NF-?B/RelA DNA binding activity , *reduced* [TNF] , and enhanced interleukin-4 production . Negative_regulation TNF HNRNPH1 22207023 2549737 This is the first study , which reports the *role* of PDIA3 and in [TNF-a] production in DENV infected cells . Negative_regulation TNF HNRNPK 24751651 2936603 Silencing of does not affect TAK1 mRNA synthesis or stability but enhances TAK1 mRNA translation , *resulting* in elevated [TNF-a] , IL-1ß , and IL-10 mRNA expression . Negative_regulation TNF HOXD13 14962496 1182587 [TNFalpha] secretion was *inhibited* by SPM or added 18h before stimulation in a concentration dependent manner . Negative_regulation TNF HOXD13 23623854 2795503 The interaction of RANKL with , a patented small-molecule *inhibitor* of [TNF-a] , was also studied in a fluorescence binding assay resulting in a Kd value of 14.1 ± 0.5 µM . Negative_regulation TNF HPN 2174282 145667 In vitro , also significantly *suppressed* [TNF] activity when it was co-incubated with PBM and LPS . Negative_regulation TNF HRC 16496340 1541321 HRC 203 had greater anti-viral activity on both isolated hepatocytes and macrophages , whereas both ribavirin and 203 *inhibited* production of the pro-inflammatory cytokines interferon gamma (IFN-gamma) and [tumor necrosis factor alpha (TNF-alpha)] by macrophages . Negative_regulation TNF HSF1 10734139 678839 These data suggest that partial activation of during exposure to febrile , sub-heat shock temperatures may *block* [TNFalpha] transcription by binding to its proximal promoter or 5'-untranslated region . Negative_regulation TNF HSF1 11734555 904606 This suggests that might *repress* [TNFalpha] transcription through redundant mechanisms , some of which might not require high affinity binding of HSF-1 . Negative_regulation TNF HSF1 19846753 2187479 Using HSF1-null mice , we confirmed that is *required* for FRT induced repression of [TNF-alpha] in vitro by LPS stimulated bone marrow derived macrophages and in vivo in mice challenged intratracheally with LPS . Negative_regulation TNF HSPB8 18381796 1892924 In contrast , both LPS and *resulted* in significantly lower secretion of IL-6 , [TNF-alpha] , and IL-10 in those who carried the variant , whereas the frequency of CD14+ cells was higher in these individuals . Negative_regulation TNF HSPD1 15214052 1262864 In this study , we demonstrate that pretreatment of monocytes with human *results* in a suppression of [TNF-alpha] production on restimulation with HSP60 . Negative_regulation TNF HSPD1 23620217 2778784 Furthermore , the enhanced expression of was reduced and the LPS induced release of [TNF-a] and HSP60 were *inhibited* . Negative_regulation TNF HSPG2 17158358 1716896 In this study we investigated the *role* of phosphatidylcholine-specific phospholipase C ( ) in silica stimulated induction of [TNF-alpha] and IL-1beta and how PC-PLC activity is regulated by silica in a rat alveolar macrophage model . Negative_regulation TNF HSPG2 22798676 2639937 In a second model of sepsis , activation also *inhibited* the production of [TNF-a] and IL-1ß following systemic LPS challenge . Negative_regulation TNF HSPG2 23811853 2834482 [TNF-a] protein expression and TACE enzymatic activity in muscle were significantly *reduced* by PIO but not . Negative_regulation TNF HSPG2 9414418 408184 Inhibition of [TNF-alpha] *induced* activation , however , seemed to be regulated at a post-receptor level as PLC inhibition and receptor occupancy did not correlate . Negative_regulation TNF HTR1A 16938291 1615365 Treatment with CP 's alone indicated that agonistic effects on beta-2 adrenoceptors and antagonistic effects on alpha-2 , <5-HT1A> and 5-HT1D receptors *resulted* in statistically significant decreased [TNF-alpha] levels in comparison to the LPS-control group . Negative_regulation TNF HTR1D 16938291 1615366 Treatment with CP 's alone indicated that agonistic effects on beta-2 adrenoceptors and antagonistic effects on alpha-2 , 5-HT1A and <5-HT1D> receptors *resulted* in statistically significant decreased [TNF-alpha] levels in comparison to the LPS-control group . Negative_regulation TNF HTR7 18475579 290009 The chemotactic activity of the [TNFalpha] 36-62 peptide on PMN , was *inhibited* by , Utr-1 and soluble p55 receptor , which shows that the peptide possessed the ability to induce chemotaxis through the TNF receptors . Negative_regulation TNF HUNK 11991968 938612 To determine the *role* of in the production of [TNF-alpha] , we focused on the function of its nonstructural protein , NS1 , and established monocytic U937 lines transduced with the NS1 gene under the control of an inducible promoter . Negative_regulation TNF IARS 21321205 2398945 Using inhibitory immunoregulatory DNA sequences ( IRSs ) specific to TLR7 , TLR8 , and TLR9 , we show that the TLR8 inhibitor significantly *diminishes* production of [TNF-a] , IL-6 , and IL-10 and completely abrogates transcription of IFN-ß in Bb-stimulated monocytes . Negative_regulation TNF IBD2 21903765 2511185 chemokine receptor-7 ) -expressing mDC and *reduced* their secretion of [tumor necrosis factor (TNF)-a] and interleukin (IL)-6 while increasing IL-8 . Negative_regulation TNF IBD3 21903765 2511181 chemokine receptor-7 ) -expressing mDC and *reduced* their secretion of [tumor necrosis factor (TNF)-a] and interleukin (IL)-6 while increasing IL-8 . Negative_regulation TNF IBD4 21903765 2511186 chemokine receptor-7 ) -expressing mDC and *reduced* their secretion of [tumor necrosis factor (TNF)-a] and interleukin (IL)-6 while increasing IL-8 . Negative_regulation TNF IBD5 21903765 2511187 chemokine receptor-7 ) -expressing mDC and *reduced* their secretion of [tumor necrosis factor (TNF)-a] and interleukin (IL)-6 while increasing IL-8 . Negative_regulation TNF IBD6 21903765 2511188 chemokine receptor-7 ) -expressing mDC and *reduced* their secretion of [tumor necrosis factor (TNF)-a] and interleukin (IL)-6 while increasing IL-8 . Negative_regulation TNF IBD7 21903765 2511182 chemokine receptor-7 ) -expressing mDC and *reduced* their secretion of [tumor necrosis factor (TNF)-a] and interleukin (IL)-6 while increasing IL-8 . Negative_regulation TNF IBD8 21903765 2511183 chemokine receptor-7 ) -expressing mDC and *reduced* their secretion of [tumor necrosis factor (TNF)-a] and interleukin (IL)-6 while increasing IL-8 . Negative_regulation TNF IBD9 21903765 2511184 chemokine receptor-7 ) -expressing mDC and *reduced* their secretion of [tumor necrosis factor (TNF)-a] and interleukin (IL)-6 while increasing IL-8 . Negative_regulation TNF ICAM1 11461170 839069 Insulin seems to have the ability to suppress the production of [tumor necrosis factor-alpha] and superoxide anion , enhance the synthesis of nitric oxide and *inhibit* the expression of ( ICAM-1 ) through stimulation of nitric oxide . Negative_regulation TNF ICAM1 11520077 851916 On the other hand , and anti-LFA-1 Abs *inhibited* IL-18 induced production of three cytokines , IL-12 , IFN-gamma , and [TNF-alpha] , by 60 and 40 % , respectively . Negative_regulation TNF ICAM1 12505729 1038261 PD analyses suggested that in NHS samples containing CsA+SRL ( n=5 ) , ( 1 ) PMA-Ionomycin stimulated T-cell expression of intracellular IL-2 , [TNF-alpha] , and IFN-gamma was inhibited by CsA , and minimally by SRL , and ( 2 ) the two agents *inhibited* pokeweed mitogen ( PWM ) -stimulated B-cell expression of and CD95 , but not CD86 ( ICAM-1 , Fas antigen , and B7.2 ) , synergistically . Negative_regulation TNF ICAM1 12538815 1050395 In the present study , we demonstrate that LPS ( 1-1000 pg/ml ) concentration dependently up-regulated the expression of , B7.1 , and B7.2 on human monocytes using fluorescence activated cell sorting analysis , and that [tumor necrosis factor (TNF)-alpha] production induced by LPS in peripheral blood mononuclear cells ( PBMCs ) was *inhibited* by the addition of antibodies against these adhesion molecules , suggesting the dependence of TNF-alpha production on cell-cell interaction through these adhesion molecules . Negative_regulation TNF ICAM1 15698778 1372334 Novel thiocoumarins as inhibitors of [TNF-alpha] *induced* expression on human umbilical vein endothelial cells ( HUVECs ) and microsomal lipid peroxidation . Negative_regulation TNF ICAM1 17938380 1825685 Renal tumor necrosis factor-alpha and expression increased , and Cyp2c23 expression decreased in ANG/HS hypertension compared with the HS group , and CCR2b inhibition *reduced* [tumor necrosis factor-alpha] and intercellular adhesion molecule-1 and increased Cyp2c23 expression . Negative_regulation TNF ICAM1 19123332 2004911 PrG ( 40 mg x kg ( -1 ) d ( -1 ) ) could decrease the serum level of inflammatory factor [TNF-alpha] , and slightly *inhibit* COX-2 and protein expression in ischemic myocardium of AMI rats . Negative_regulation TNF ICAM1 20431193 2247461 [TNF-alpha] bound to 14 nm CB *induced* a level of expression that was no greater than the control level , suggesting that the TNF-alpha activity may be inhibited . Negative_regulation TNF ICAM1 8757962 377782 [TNF-alpha] but not IFN-gamma was detected in the supernatant of co-culture between KC and AH70 cells , and this production was partially *inhibited* by and anti-CD18 . Negative_regulation TNF ICAM1 9712747 527382 In addition , clearly *inhibited* the fimbria induced expression of IL-1beta and [TNF-alpha] genes in the cells . Negative_regulation TNF ICOS 15368302 1294916 We show that , although blocking *resulted* in a decrease in [TNF-alpha] and the Th2 cytokines IL-4 and IL-5 and serum levels of total IgE , it did not affect the expulsion of the adult parasites . Negative_regulation TNF IDO1 24696473 2949408 EBV infection also activated the mitogen activated protein kinase (MAPK) p38 and NF-?B , and the inhibition of these two pathways with SB202190 and SN50 almost abrogated [TNF-a] and IL-6 production and *inhibited* production . Negative_regulation TNF IFI44 11134043 794926 Phosphorylation of correlated with an increase of activity , and [tumor necrosis factor-alpha] levels were significantly *reduced* by addition of inhibitors of p42/44 and p38 , PD 98059 and SB 203580 , respectively . Negative_regulation TNF IFI44 16946004 1639274 Finally , the blocking of MAPK activation *prevented* [TNFalpha] inhibition of FSH dependent increases in P450AROM and inhibin alpha-subunit mRNA levels , thus indicating that p44/42 MAPK mediated ICER expression may be accountable for the effects of TNFalpha on the expression of both proteins . Negative_regulation TNF IFIT2 19108715 2006838 Forced expression *represses* LPS induced [TNF-alpha] expression at posttranscriptional levels . Negative_regulation TNF IFIT5 10373525 622806 Inhibition of double stranded RNA- and [tumor necrosis factor] alpha *mediated* apoptosis by tetratricopeptide repeat protein and cochaperone ( IPK ) . Negative_regulation TNF IFNA1 15481160 1320361 can *inhibit* [TNF-alpha] secretion by mast cells in vitro . Negative_regulation TNF IFNA1 1756531 174000 Endogenous produced by Kupffer cells *inhibits* interleukin-1 , [tumor necrosis factor] alpha production and interleukin-2 induced activation of nonparenchymal liver cells . Negative_regulation TNF IFNA1 17887935 1797404 The three herbal extracts significantly increased production , but *inhibited* the release of [tumor necrosis factor-gamma] and interleukin (IL)-1beta . Negative_regulation TNF IFNA1 7759599 307813 activates cytotoxic function but *inhibits* interleukin-2 mediated proliferation and [tumor necrosis factor-alpha] secretion by immature human natural killer cells . Negative_regulation TNF IFNA10 15481160 1320362 can *inhibit* [TNF-alpha] secretion by mast cells in vitro . Negative_regulation TNF IFNA10 1756531 174001 Endogenous produced by Kupffer cells *inhibits* interleukin-1 , [tumor necrosis factor] alpha production and interleukin-2 induced activation of nonparenchymal liver cells . Negative_regulation TNF IFNA10 17887935 1797405 The three herbal extracts significantly increased production , but *inhibited* the release of [tumor necrosis factor-gamma] and interleukin (IL)-1beta . Negative_regulation TNF IFNA10 7759599 307814 activates cytotoxic function but *inhibits* interleukin-2 mediated proliferation and [tumor necrosis factor-alpha] secretion by immature human natural killer cells . Negative_regulation TNF IFNA13 15481160 1320363 can *inhibit* [TNF-alpha] secretion by mast cells in vitro . Negative_regulation TNF IFNA13 1756531 174002 Endogenous produced by Kupffer cells *inhibits* interleukin-1 , [tumor necrosis factor] alpha production and interleukin-2 induced activation of nonparenchymal liver cells . Negative_regulation TNF IFNA13 17887935 1797406 The three herbal extracts significantly increased production , but *inhibited* the release of [tumor necrosis factor-gamma] and interleukin (IL)-1beta . Negative_regulation TNF IFNA13 7759599 307815 activates cytotoxic function but *inhibits* interleukin-2 mediated proliferation and [tumor necrosis factor-alpha] secretion by immature human natural killer cells . Negative_regulation TNF IFNA14 15481160 1320364 can *inhibit* [TNF-alpha] secretion by mast cells in vitro . Negative_regulation TNF IFNA14 1756531 174003 Endogenous produced by Kupffer cells *inhibits* interleukin-1 , [tumor necrosis factor] alpha production and interleukin-2 induced activation of nonparenchymal liver cells . Negative_regulation TNF IFNA14 17887935 1797407 The three herbal extracts significantly increased production , but *inhibited* the release of [tumor necrosis factor-gamma] and interleukin (IL)-1beta . Negative_regulation TNF IFNA14 7759599 307816 activates cytotoxic function but *inhibits* interleukin-2 mediated proliferation and [tumor necrosis factor-alpha] secretion by immature human natural killer cells . Negative_regulation TNF IFNA16 15481160 1320365 can *inhibit* [TNF-alpha] secretion by mast cells in vitro . Negative_regulation TNF IFNA16 1756531 174004 Endogenous produced by Kupffer cells *inhibits* interleukin-1 , [tumor necrosis factor] alpha production and interleukin-2 induced activation of nonparenchymal liver cells . Negative_regulation TNF IFNA16 17887935 1797408 The three herbal extracts significantly increased production , but *inhibited* the release of [tumor necrosis factor-gamma] and interleukin (IL)-1beta . Negative_regulation TNF IFNA16 7759599 307817 activates cytotoxic function but *inhibits* interleukin-2 mediated proliferation and [tumor necrosis factor-alpha] secretion by immature human natural killer cells . Negative_regulation TNF IFNA17 15481160 1320366 can *inhibit* [TNF-alpha] secretion by mast cells in vitro . Negative_regulation TNF IFNA17 1756531 174005 Endogenous produced by Kupffer cells *inhibits* interleukin-1 , [tumor necrosis factor] alpha production and interleukin-2 induced activation of nonparenchymal liver cells . Negative_regulation TNF IFNA17 17887935 1797409 The three herbal extracts significantly increased production , but *inhibited* the release of [tumor necrosis factor-gamma] and interleukin (IL)-1beta . Negative_regulation TNF IFNA17 7759599 307818 activates cytotoxic function but *inhibits* interleukin-2 mediated proliferation and [tumor necrosis factor-alpha] secretion by immature human natural killer cells . Negative_regulation TNF IFNA2 15481160 1320367 can *inhibit* [TNF-alpha] secretion by mast cells in vitro . Negative_regulation TNF IFNA2 1756531 174006 Endogenous produced by Kupffer cells *inhibits* interleukin-1 , [tumor necrosis factor] alpha production and interleukin-2 induced activation of nonparenchymal liver cells . Negative_regulation TNF IFNA2 17887935 1797410 The three herbal extracts significantly increased production , but *inhibited* the release of [tumor necrosis factor-gamma] and interleukin (IL)-1beta . Negative_regulation TNF IFNA2 7759599 307819 activates cytotoxic function but *inhibits* interleukin-2 mediated proliferation and [tumor necrosis factor-alpha] secretion by immature human natural killer cells . Negative_regulation TNF IFNA21 15481160 1320368 can *inhibit* [TNF-alpha] secretion by mast cells in vitro . Negative_regulation TNF IFNA21 1756531 174007 Endogenous produced by Kupffer cells *inhibits* interleukin-1 , [tumor necrosis factor] alpha production and interleukin-2 induced activation of nonparenchymal liver cells . Negative_regulation TNF IFNA21 17887935 1797411 The three herbal extracts significantly increased production , but *inhibited* the release of [tumor necrosis factor-gamma] and interleukin (IL)-1beta . Negative_regulation TNF IFNA21 7759599 307820 activates cytotoxic function but *inhibits* interleukin-2 mediated proliferation and [tumor necrosis factor-alpha] secretion by immature human natural killer cells . Negative_regulation TNF IFNA4 15481160 1320369 can *inhibit* [TNF-alpha] secretion by mast cells in vitro . Negative_regulation TNF IFNA4 1756531 174008 Endogenous produced by Kupffer cells *inhibits* interleukin-1 , [tumor necrosis factor] alpha production and interleukin-2 induced activation of nonparenchymal liver cells . Negative_regulation TNF IFNA4 17887935 1797412 The three herbal extracts significantly increased production , but *inhibited* the release of [tumor necrosis factor-gamma] and interleukin (IL)-1beta . Negative_regulation TNF IFNA4 7759599 307821 activates cytotoxic function but *inhibits* interleukin-2 mediated proliferation and [tumor necrosis factor-alpha] secretion by immature human natural killer cells . Negative_regulation TNF IFNA5 15481160 1320370 can *inhibit* [TNF-alpha] secretion by mast cells in vitro . Negative_regulation TNF IFNA5 1756531 174009 Endogenous produced by Kupffer cells *inhibits* interleukin-1 , [tumor necrosis factor] alpha production and interleukin-2 induced activation of nonparenchymal liver cells . Negative_regulation TNF IFNA5 17887935 1797413 The three herbal extracts significantly increased production , but *inhibited* the release of [tumor necrosis factor-gamma] and interleukin (IL)-1beta . Negative_regulation TNF IFNA5 7759599 307822 activates cytotoxic function but *inhibits* interleukin-2 mediated proliferation and [tumor necrosis factor-alpha] secretion by immature human natural killer cells . Negative_regulation TNF IFNA6 15481160 1320371 can *inhibit* [TNF-alpha] secretion by mast cells in vitro . Negative_regulation TNF IFNA6 1756531 174010 Endogenous produced by Kupffer cells *inhibits* interleukin-1 , [tumor necrosis factor] alpha production and interleukin-2 induced activation of nonparenchymal liver cells . Negative_regulation TNF IFNA6 17887935 1797414 The three herbal extracts significantly increased production , but *inhibited* the release of [tumor necrosis factor-gamma] and interleukin (IL)-1beta . Negative_regulation TNF IFNA6 7759599 307823 activates cytotoxic function but *inhibits* interleukin-2 mediated proliferation and [tumor necrosis factor-alpha] secretion by immature human natural killer cells . Negative_regulation TNF IFNA7 15481160 1320372 can *inhibit* [TNF-alpha] secretion by mast cells in vitro . Negative_regulation TNF IFNA7 1756531 174011 Endogenous produced by Kupffer cells *inhibits* interleukin-1 , [tumor necrosis factor] alpha production and interleukin-2 induced activation of nonparenchymal liver cells . Negative_regulation TNF IFNA7 17887935 1797415 The three herbal extracts significantly increased production , but *inhibited* the release of [tumor necrosis factor-gamma] and interleukin (IL)-1beta . Negative_regulation TNF IFNA7 7759599 307824 activates cytotoxic function but *inhibits* interleukin-2 mediated proliferation and [tumor necrosis factor-alpha] secretion by immature human natural killer cells . Negative_regulation TNF IFNA8 15481160 1320373 can *inhibit* [TNF-alpha] secretion by mast cells in vitro . Negative_regulation TNF IFNA8 1756531 174012 Endogenous produced by Kupffer cells *inhibits* interleukin-1 , [tumor necrosis factor] alpha production and interleukin-2 induced activation of nonparenchymal liver cells . Negative_regulation TNF IFNA8 17887935 1797416 The three herbal extracts significantly increased production , but *inhibited* the release of [tumor necrosis factor-gamma] and interleukin (IL)-1beta . Negative_regulation TNF IFNA8 7759599 307825 activates cytotoxic function but *inhibits* interleukin-2 mediated proliferation and [tumor necrosis factor-alpha] secretion by immature human natural killer cells . Negative_regulation TNF IFNB1 10462039 639896 Furthermore did not modulate the expression of adhesion molecules on either stimulated leukocytes or activated HB-MVEC , but partially *reduced* [TNF] and interleukin-1 production from stimulated leukocytes during coculture with HB-MVEC . Negative_regulation TNF IFNB1 11433430 832175 Also , [TNF-alpha] expression in macrophages was significantly *reduced* by and by the combination therapy . Negative_regulation TNF IFNB1 11444907 834153 In co-cultures of autologous T lymphocytes and monocytes stimulated by phytohaemagglutinin ( PHA ) , *inhibited* the production of [TNF-alpha] and IL-1beta by 88 and 98 % , respectively , whereas the simultaneous production of IL-1 receptor antagonist (IL-1Ra) , was enhanced two-fold . Negative_regulation TNF IFNB1 11444907 834155 When monocytes were activated by plasma membranes of stimulated T cells , slightly *inhibited* the production of [TNF-alpha] and IL-1beta , while enhancing 1.5-fold that of IL-1Ra . Negative_regulation TNF IFNB1 14698849 1195811 Furthermore , we recently demonstrated that *inhibits* the production of IL-1beta and [tumor necrosis factor-alpha (TNF)] in human monocytes activated by cellular contact with stimulated T cells , a mechanism which we suspected of playing an important part in the pathogenesis of chronic inflammatory diseases including MS . Negative_regulation TNF IFNB1 14698849 1195819 *inhibited* the expression ( mRNA ) and production ( protein ) of IL-1beta and [TNF] , while enhancing those of IL-1Ra in monocytes activated by msHUT . Negative_regulation TNF IFNB1 1756531 174013 Endogenous produced by Kupffer cells *inhibits* interleukin-1 , [tumor necrosis factor] alpha production and interleukin-2 induced activation of nonparenchymal liver cells . Negative_regulation TNF IFNB1 1846503 151683 Antibodies against IFN beta block this synergism , implying a *role* of in the antiviral activity of [TNF] plus IFN gamma . Negative_regulation TNF IFNB1 3020123 63236 Both IFN-alpha and exerted an antagonistic effect on IFN-gamma induced stimulation of TNF receptor expression in HT-29 cells , but did not *inhibit* [TNF] receptor induction by IFN-gamma in HeLa cells . Negative_regulation TNF IFNB1 9239408 445872 We also report that ( IFNbeta-1b ) , a drug that alleviates symptoms in MS , downregulates the expression of CD49d and *reduces* [TNF-alpha] production , mechanisms which can help account for its efficacy in MS . Negative_regulation TNF IFNB1 9459613 475707 not only *inhibits* interleukin-1beta and [tumor necrosis factor-alpha] but stimulates interleukin-1 receptor antagonist production in human peripheral blood mononuclear cells . Negative_regulation TNF IFNG 10618692 575987 [TNFalpha] and IL-10 were also *detected* in culture supernatants from in vitro stimulated B-CLL cells , whereas was undetectable in these cultures and rarely positive in serum . Negative_regulation TNF IFNG 10805216 691950 as well as the GCs , Dexamethasone and Budesonide , *inhibited* [TNF-alpha] induced IL-8 secretion in a dose dependent manner . Negative_regulation TNF IFNG 11179286 786782 Cs given after TSST-1 also did not inhibit enhancement of LPS induced serum [TNF-alpha] by TSST-1 but *inhibited* the enhancement effect of TSST-1 on LPS induced serum by 50 % . Negative_regulation TNF IFNG 11602691 871226 Blockade of phosphodiesterase 4 with rolipram reduced the production of [tumor necrosis factor (TNF)-alpha] , interleukin (IL)-5 , IL-10 , and IL-2 but poorly *inhibited* cell proliferation and production by activated human T cells . Negative_regulation TNF IFNG 12175542 975172 In this report , we demonstrated that FA15 , in contrast to FA , markedly suppressed the combined lipopolysaccharide and induced protein expressions of inducible nitric oxide synthase and cyclooxygenase-2 , and also *inhibited* the release of [tumor necrosis factor-alpha] accompanied by suppression of I-kappa B degradation in RAW264.7 , a murine macrophage cell line . Negative_regulation TNF IFNG 12498767 1026398 Ad-IL-10 transduced bone-marrow derived macrophages ( BMDM ) produced large amounts of IL-10 in culture , and their [TNF-alpha] production was decreased in *response* to and LPS . Negative_regulation TNF IFNG 15208038 1261743 Treatment of infected mice with pentoxifylline , known to decrease production and to *inhibit* the [TNF-alpha] gene transcription , reduced the placental production of TNF , and the fetal mortality in comparison to control animals . Negative_regulation TNF IFNG 15240693 1270275 Indeed , ovaries with neonatal AOD expressed high levels of IFN-gamma and [TNF-alpha] which correlated with disease severity , and the disease was *inhibited* by or TNF-alpha Ab. Importantly , disease was enhanced by recombinant IFN-gamma , and treatment of T cell donors with IFN-gamma Ab also significantly reduced adoptive transfer of neonatal AOD . Negative_regulation TNF IFNG 15256756 1272288 Zineb and alachlor , on the other hand , *enhanced* LPS induced [TNF-alpha] production by mouse peritoneal macrophages ex vivo , while alachlor inhibited induced NO production ex vivo . Negative_regulation TNF IFNG 15722640 1382871 Interleukin (IL)-5 , IL-6 , and [tumor necrosis factor (TNF)] *induced* an eosinophil shape change , whereas significantly inhibited the shape change . Negative_regulation TNF IFNG 1639488 194649 Our results demonstrate that TNF production by macrophages is altered during E. histolytica infection and in response to amoebae and suggest a *role* for and prostaglandin E2 in regulating [TNF] production during the infection . Negative_regulation TNF IFNG 16487246 1524842 added prior to infection of mouse peritoneal macrophages with IgA opsonized bacilli *resulted* in a synergistic increase of nitric oxide and [TNFalpha] production and a 2-3 fold decrease in bacterial counts . Negative_regulation TNF IFNG 16487932 1528516 Herein we report that the repressible/inducible over-expression of wild-type SHP-1 in a subclone of RAW 264.7 macrophages ( RAW-TT10 cells ) inhibited both [TNF] secretion and iNOS protein accumulation in *response* to stimulation with lipopolysaccharide (LPS) and recombinant murine and led to diminished LPS mediated tyrosine phosphorylation of vav1 . Negative_regulation TNF IFNG 1846894 153366 *reduces* specific binding of [tumor necrosis factor] on murine macrophages . Negative_regulation TNF IFNG 1846894 153367 This effect was dose dependent and maximal at 100 U/ml . also *reduced* specific [TNF] binding to preexisting receptors ( 50 % inhibition in 3 h ) , but IFN-gamma did not change the internalization rate of TNF . Negative_regulation TNF IFNG 18475052 1910474 Further studies revealed that induced the expression of TNF-alpha mRNA and protein , which synergistically induced NO production , and GLP-1 treatment *inhibited* this induction of [TNF-alpha] . Negative_regulation TNF IFNG 1850219 155535 Both normal and patient sera , at effective concentrations , only slightly affected the binding of [125I-TNF] to ML-1 cells , but any of these sera significantly *inhibited* the binding of <125I-IFN-gamma> to U-937 cells or to THP-1 cells . Negative_regulation TNF IFNG 18651847 1967032 At 2 h , minocycline HCl *induced* high levels of IL-10 , [TNFalpha] and IFNgamma , while CHX reduced the levels of TNFalpha and . Negative_regulation TNF IFNG 19109405 2042204 Although both [TNF-alpha] and IFN-gamma increased IL-8 synthesis and CD58 expression by the HT-29 cells , only *reduced* IL-8 production by IELs . Negative_regulation TNF IFNG 1910954 167451 Carbetimer did not stimulate [TNF-alpha] release from isolated normal human monocytes or lymphocytes , but it markedly *inhibited* T-lymphocyte production of , which became undetectable at a concentration of 1 mg of Carbetimer/ml . Negative_regulation TNF IFNG 19446335 2090675 The expression of CD59 could be augmented by IL-1 beta , IL-6 and [TNF-alpha] but was *suppressed* by . Negative_regulation TNF IFNG 2105994 127030 Although , IL-6 , granulocyte CSF , and granulocyte-macrophage CSF induced nitroblue tetrazolium reducing activity of U-937 cells , only IFN-gamma , and [TNF] *induced* it synergistically in combination with TGF-beta 1 . Negative_regulation TNF IFNG 2115318 137413 In vitro combination of TNF with interferon-alpha (IFN-alpha) and IFN-beta resulted in additive growth inhibitory effects , while *enhanced* the [TNF] mediated growth inhibition in a synergistic way . Negative_regulation TNF IFNG 21438292 2361498 This Pd salt inhibited IFN-gamma , TNF-alpha , IL-10 and IL-17 release from PBMC of non-atopic women , whereas Pd nanoparticles enhanced the release of and *inhibited* that of [TNF-alpha] and IL-17 . Negative_regulation TNF IFNG 21502320 2434834 The induced GTPase , mGBP-2 , *inhibits* [tumor necrosis factor alpha (TNF-alpha)] induction of matrix metalloproteinase-9 (MMP-9) by inhibiting NF-kappaB and Rac protein . Negative_regulation TNF IFNG 2509302 120464 did not change the binding affinity of TNF receptors in the four cell lines , but *increased* the number of binding sites for [TNF] in HeLa S3 and SCH cells . Negative_regulation TNF IFNG 3117378 79222 Regulation of [tumor necrosis factor (TNF)] expression : *enhances* the accumulation of mRNA for TNF induced by lipopolysaccharide in murine peritoneal macrophages . Negative_regulation TNF IFNG 7489766 332303 [Tumor necrosis factor-alpha] induction of major histocompatibility complex class II antigen expression is *inhibited* by in a monocytic cell line . Negative_regulation TNF IFNG 7590881 336351 BMM treated with amoebic proteins and stimulated with LPS , or , *resulted* in a 33 % and 50 % reduction in [TNF-alpha] mRNA levels , respectively . Negative_regulation TNF IFNG 7642223 317953 *resulted* in secretion of [TNF-alpha] in day 5 , day 7 , and day 9 BMDM after 4-8 hr of stimulation . Negative_regulation TNF IFNG 7680648 211625 IL-4 down-regulated and IFN gamma *enhanced* the [TNF alpha-] and IL-1 beta induced increase in RANTES mRNA , whereas the induction of IL-8 mRNA by TNF alpha or IL-1 beta was inhibited by and augmented by IL-4 . Negative_regulation TNF IFNG 7743669 306071 LPS , or TNF-alpha had no effect on spontaneous IL-6 production , and neither *resulted* in the secretion of IL-1 beta or [TNF-alpha] . Negative_regulation TNF IFNG 8932856 398034 In the MLC , a feedback mechanism between TNF-alpha and IFN-gamma exists , since anti-TNF-gamma reduced the secretion of IFN-gamma and *inhibited* the release of [TNF-alpha] . Negative_regulation TNF IFNG 9058823 417718 In cultures of murine monocyte/macrophage containing cell populations , i.e. , alveolar , peritoneal , spleen , bone marrow cells , or blood , the presence of GM-CSF or ( 10 ng/ml ) *resulted* in an enhanced release of [TNF-alpha] initiated by 1 microg/ml LPS . Negative_regulation TNF IGF1 10404006 629135 CGRP inhibits osteoclasts , stimulates and *inhibits* [tumor necrosis factor] alpha production by osteoblasts in vitro . Negative_regulation TNF IGF1 11571581 864325 Local gene transfer *attenuates* the mRNA expression of the inflammatory cytokines IL-1beta and [TNF-alpha] in the burn wound . Negative_regulation TNF IGF1 12697682 1081350 The purpose of the present study was to determine whether LPS alters the expression of [TNF alpha] and IGF-I in mouse skeletal muscle and whether TNF alpha directly *inhibits* mRNA expression in C2C12 myoblasts . Negative_regulation TNF IGF1 18004231 1943903 *inhibited* increases in [TNF-alpha] , IL-1 beta , and cytokine induced neutrophil chemoattractant 1 caused by GalN/LPS in serum and liver and enhanced serum IL-10 . Negative_regulation TNF IGF1 18201559 1870321 , but not GH , *inhibited* the FFA induced TLR2 and [TNF-alpha] expression in 3T3-L1 cells . Negative_regulation TNF IGF1 21872589 2486578 On the contrary , decreased oxidative stress and *suppressed* [TNF-a] levels and these effects were blocked by l-NAME . Negative_regulation TNF IGF1 21957737 2488226 [TNF-alpha] and IFN-gamma attenuated the expression of IGFBP-4 and -6 under basal conditions and in the *presence* of , and inhibited IGF-I induced IGFBP-5 expression during 5-day myogenesis . Negative_regulation TNF IGF1 21957737 2488242 [TNF-alpha] and IFN-gamma markedly attenuated p38 expression in the *presence* of on the 5th day of myogenesis . Negative_regulation TNF IGF1 9276092 450683 We recently reported that CGRP stimulates the production of the growth factor and *inhibits* that of the cytokine [tumor necrosis factor-alpha] by osteoblasts , suggesting that CGRP may control bone cell activity . Negative_regulation TNF IGF1 9413747 471608 After maturation , TGF-alpha and showed a shift in mRNA expression from caM phi to aaM phi resulting in a considerably enhanced expression of these factors in day-6 aaM phi as compared to day-6 caM phi and coM phi while PDGF-A , MK , and [TNF-alpha] remained *suppressed* in day 6 aaM phi . Negative_regulation TNF IGFBP3 23383064 2739498 further *inhibits* [TNF-a] , CRP and high glucose induced NF-?B activity in human aortic endothelial cells ( HAECs ) and subsequently suppresses monocyte adhesion to HAEC through the IGFBP-3 receptor . Negative_regulation TNF IGKV1-27 19851077 2209549 expression *reduced* EPC activation by [tumor necrosis factor-alpha] and interleukin-1beta as determined from changes in vascular cell adhesion molecule 1 and E-selectin expression and decreased monocyte transmigration through a monolayer of EPCs . Negative_regulation TNF IGKV1-27 22685311 2621036 Small interfering RNA mediated silencing of *restored* the Lys 63-linked ubiquitination of TRAF6 as well as IL-12 and [TNF-a] levels with a concomitant decrease in IL-10 and TGF-ß synthesis in infected macrophages . Negative_regulation TNF IGSF1 25015829 2952962 We observed that *inhibited* MyD88 dependent NF-?B activation and release of [TNF-a] and IL-6 , but enhanced TIR domain containing adapter inducing IFN-ß dependent IFN regulatory factor 3 activation and release of IFN-ß upon LPS exposure . Negative_regulation TNF IKBKB 11124824 768955 We analyzed the differential *role* of I kappa B kinase 1 (IKK1) and in [tumor necrosis factor alpha (TNF-alpha)-] and interleukin-1 beta (IL-1 beta) mediated NF-kappa B activation in primary rat hepatocytes . Negative_regulation TNF IKBKB 11179444 784692 [TNF-alpha-] or C2-ceramide induced COX-2 promoter activity was *inhibited* by the dominant negative mutant of extracellular signal regulated kinase 2 , p38 , JNK , IkappaB kinase (IKK)1 , or . Negative_regulation TNF IKBKB 12847684 1109012 To investigate the potential *role* of IkappaB kinase 1 (IKK-1) and in the regulation of nuclear factor kappaB (NF-kappaB) activation and the expression of [tumor necrosis factor alpha (TNFalpha)] , as well as interleukin-1beta (IL-1beta) , IL-6 , IL-8 , vascular endothelial growth factor ( VEGF ) , and matrix metalloproteinases ( MMPs ) , in rheumatoid arthritis ( RA ) . Negative_regulation TNF IKBKB 16774932 1672068 PMA selectively causes the degradation of IkappaB kinases ( IKKs ) including IKK-gamma and IKK-beta , and subsequent inhibition of [tumor necrosis factor (TNF)] *induced* and NF-kappaB activation in human colon cancer cell line HCT-116 , but not in other gastrointestinal tract cells . Negative_regulation TNF IKBKB 17244613 1710239 Furthermore , exogenously expressed , catalytically inactive *blocked* [TNF-] but not IL-1 induced IkappaBalpha degradation in wild-type MEFs , and reconstitution of IKKalpha/beta double knockout cells with IKKalpha rescued IL-1- but not TNF induced NF-kappaB activation . Negative_regulation TNF IKBKB 19200052 2033734 Further studies show that neither overexpression of IKKbeta-KM , a kinase inactive mutant of , nor the ectopic expression of a dominant negative mutant of NFAT could *inhibit* the [TNF-alpha] induction by nickel exposure . Negative_regulation TNF IKBKB 22092970 2534691 To induce chemokine production , cells were incubated with IL-4 , IL-13 , [TNF-a] or IFN-? in *presence* or absence of dexamethasone , mithramycin A ( SP-1 inhibitor ) or the inhibitor , AS602868 . Negative_regulation TNF IKBKG 10734145 678899 has also been shown to *repress* basal and [tumor necrosis factor (TNF)] alpha induced NF-kappaB activity as well as to induce cell death when overexpressed . Negative_regulation TNF IKBKG 16399796 1520241 Skin lesion development in a mouse model of incontinentia pigmenti is triggered by deficiency in epidermal keratinocytes and *requires* [TNF] signaling . Negative_regulation TNF IKBKG 16774932 1672069 PMA selectively causes the degradation of IkappaB kinases ( IKKs ) including IKK-gamma and IKK-beta , and subsequent inhibition of [tumor necrosis factor (TNF)] *induced* and NF-kappaB activation in human colon cancer cell line HCT-116 , but not in other gastrointestinal tract cells . Negative_regulation TNF IKBKG 17314097 1719493 Interestingly , peptides spanning CCR2 and/or LZ disrupt IKKgamma-Tax and interactions and potently *inhibit* NF-kappaB activation by Tax and [tumor necrosis factor-alpha] . Negative_regulation TNF IKBKG 18515218 1918460 After 45 and 60 minutes , *caused* a significant decline in the [TNF-alpha] levels . Negative_regulation TNF IL10 10027094 591438 Salmeterol ( 0.5 mg/mL ) and ( 0.1 microgram ) only *inhibit* [TNF-alpha] increase in the BAL fluid and db-AMPc ( 2.5 micrograms/rat ) was ineffective . Negative_regulation TNF IL10 10347215 616821 Herein , we demonstrate that the ability of to *inhibit* [tumor necrosis factor alpha (TNFalpha)] production in lipopolysaccharide stimulated macrophages requires the presence of Stat3 , Jak1 , and two distinct regions of the IL-10 receptor intracellular domain . Negative_regulation TNF IL10 10347215 616826 These results thus demonstrate that *induced* inhibition of [TNFalpha] production requires two distinct regions of the IL-10 receptor intracellular domain and thereby establish a distinctive molecular basis for the developmental versus the anti-inflammatory actions of IL-10 . Negative_regulation TNF IL10 10374812 623161 Opposite to IFN-gamma , the lipid mediator prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of and *inhibited* that of [TNF] . Negative_regulation TNF IL10 10385657 625669 *suppressed* NFkappaB activation as well as messenger RNA expression of [tumor necrosis factor-alpha (TNF-alpha)] and macrophage inflammatory protein-2 ( MIP-2 ) . Negative_regulation TNF IL10 10385657 625672 In addition , *reduced* serum levels of [TNF-alpha] and MIP-2 . Negative_regulation TNF IL10 10484681 626360 *inhibits* [TNF-alpha] production in human monocytes independently of interleukin 12 and interleukin 1 beta . Negative_regulation TNF IL10 10484681 626361 Previously we demonstrated that endogenously produced *suppressed* the production of [tumor necrosis factor-alpha (TNF-alpha)] in CD3 activated T-cells via down-regulation of paracrine IL-12 secretion from APC . Negative_regulation TNF IL10 10484681 626363 Similarly to its effects on T-cells , *inhibited* monocyte [TNF-alpha] production by about half . Negative_regulation TNF IL10 10547095 564703 ( 5.0 microg ) administered 30 minutes after-injury significantly *reduced* the expression of [TNF-alpha] protein in the spinal cord and in vitro by SCI activated monocytes . Negative_regulation TNF IL10 10565564 567367 The cytokine , at 10 U and 50 U , *inhibited* only [TNFalpha] production . Negative_regulation TNF IL10 10580578 570099 *inhibits* hepatic injury and [tumor necrosis factor-alpha] and interferon-gamma mRNA expression induced by staphylococcal enterotoxin B or lipopolysaccharide in galactosamine sensitized mice . Negative_regulation TNF IL10 10594679 573099 In summary , GM-CSF promotes the generation of a pro-inflammatory type of Mphi in two different ways : first , the down-regulation of autocrine production *increases* the release of cytokines such as IL-6 and [TNF-alpha] and second , the up-regulation of membrane and soluble CD14 expression leads to a higher sensitivity towards LPS-stimulation . Negative_regulation TNF IL10 10605041 655650 Human expression in the lung *suppressed* local [TNF-alpha] production following AdV/hIL-10 ( adenovirus construct expressing human IL-10 ) delivery , but did not lead to increased or prolonged transgene expression when coexpressed with beta-galactosidase . Negative_regulation TNF IL10 10704170 672778 The present findings provide the first direct evidence that endogenous *inhibits* the production of [tumor necrosis factor-alpha] and NO and serves to protect the ischemic and reperfused myocardium through the suppression of neutrophil recruitment . Negative_regulation TNF IL10 10719355 676933 ( 10 and 100 ng/ml ) and IL-4 ( 5 and 50 U/ml ) *suppressed* the LPS induced production of NO , IL-6 , and [TNF-alpha] in a dose dependent manner , whereas TGF-beta1/beta2 ( 2 and 20 ng/ml ) only suppressed NO production . Negative_regulation TNF IL10 10975994 729521 Results indicated that steady state mRNA levels of [tumour necrosis factor-alpha (TNF)] and interleukin 1-beta (IL-1) decreased in the *presence* of . Negative_regulation TNF IL10 10975994 729523 also *inhibited* [TNF] secretion and NF-kappa B activation induced by another stimulus , staphylococcal toxin . Negative_regulation TNF IL10 11083814 750529 In line with its downregulatory effects on neutrophil derived proinflammatory cytokines , potently *inhibited* [TNF-alpha] , IL-1beta , IL-8 , and MIP-1beta production triggered by OMV . Negative_regulation TNF IL10 11145695 770253 The produced by infected macrophages prevented macrophage activation and *diminished* their production of IL-12 and [TNF-alpha] . Negative_regulation TNF IL10 11169439 783420 Antibody blocking experiments showed that CT inhibition of IL-12 and [TNF-alpha] production was *mediated* by increased production , in that addition of anti-IL-10 monoclonal antibody abrogated CT inhibition . Negative_regulation TNF IL10 11180507 784980 These results indicate that in glia from WT mice , exogenous *attenuates* LPS-induces release of NO , PGE ( 2 ) , [TNF-alpha] and IL-1beta . Negative_regulation TNF IL10 11332442 809057 Since *inhibits* IL-1 and [TNF-alpha] expression , its upregulation in osteoarthritic chondrocytes may counteract the detrimental effects of these catabolic cytokines . Negative_regulation TNF IL10 11353686 815056 Interleukin (IL)-1 and tumor necrosis factor (TNF) promote slow-wave sleep ( SWS ) , whereas *inhibits* the synthesis of IL-1 and [TNF] and promotes waking . Negative_regulation TNF IL10 11432585 831926 Exposure of the monocyte/macrophages to PMMA particles resulted in a dose dependent release of interleukin-6 and tumor necrosis factor-alpha at 48 h . *reduced* the levels of interleukin-6 and [tumor necrosis factor-alpha] release by macrophages in response to PMMA particles in a dose dependent manner . Negative_regulation TNF IL10 11455121 837905 Because can *inhibit* [TNFalpha] , IL-1 , IL-6 , and IL-8 , the lack of IL-10 in the TMJ in the face of the other studies showing increases in TNFalpha , IL-1beta , IL-6 , and IL-8 could partially explain the exacerbation of the associated osteoarthritis . Negative_regulation TNF IL10 11469886 840934 We examined the *role* of endogenous in the regulation of NF-kappaB activation and [TNF-alpha] production in human monocytes by cAMP . Negative_regulation TNF IL10 11504795 847881 We propose that the increase in [TNF-alpha] release is *due* to a specific inhibition of release by Lektinol . Negative_regulation TNF IL10 11505428 847920 Enzyme linked immunosorbent assay and reverse transcription-polymerase chain reaction showed that both IL-4 and significantly *reduced* the production of [TNF-alpha] and IL-6 . Negative_regulation TNF IL10 11564774 863315 , however , *inhibited* LPS induced [TNF-alpha] production even in these cells , indicating that the cells still possessed responsiveness to IL-10 . Negative_regulation TNF IL10 11686517 875867 Moreover , we demonstrated that M. furfur modulates proinflammatory and immunomodulatory cytokine synthesis by downregulating IL-1alpha and by *inhibiting* IL-6 and [TNF-alpha] and by upregulating and TGF-beta1 . Negative_regulation TNF IL10 11810532 766550 The above results suggested that *inhibited* [TNF-alpha] production and neutrophil activity in LPS induced acute lung injury , which led to a reduction of the lung tissue injury . Negative_regulation TNF IL10 11927652 927105 Stimulation of DC with IFN-gamma increased the release of interleukin (IL)-12 and [tumor necrosis factor-alpha] and *inhibited* the production of . Negative_regulation TNF IL10 11958828 931305 Estriol was also found to alter the cytokine profile of T cells toward Th2 phenotype by up-regulating the production of and *inhibiting* [TNFalpha] secretion of T cells . Negative_regulation TNF IL10 11994432 938962 The molecular pathways by which *inhibits* [TNF-alpha] production are obscure , with diverse mechanisms having been published . Negative_regulation TNF IL10 11997699 939530 These results suggest that thrombin induces IL-10 and [TNF-alpha] expression through different signaling mechanisms , and that *inhibits* TNF-alpha release as a negative feedback regulation . Negative_regulation TNF IL10 12107190 984656 In these mice , *inhibited* endotoxin induced [tumor necrosis factor] production and neutrophil accumulation . Negative_regulation TNF IL10 12111847 963558 The LPS induced secretion of IL-1beta and TNF-alpha was only reduced after application of ACM , whereas IL-4 or did not *inhibit* IL-1beta- or [TNF-alpha] secretion . Negative_regulation TNF IL10 12161227 971919 Independently of clinical severity , profoundly *inhibits* [TNF-alpha] release from PBMCs isolated from patients with chronic HF . IL-10 is , therefore , a potential therapy for use in chronic HF associated with inflammatory immune activation . Negative_regulation TNF IL10 12189567 979991 *inhibits* in vitro hematopoietic suppression and production of interferon-gamma and [tumor necrosis factor-alpha] by peripheral blood mononuclear cells from patients with aplastic anemia . Negative_regulation TNF IL10 12193748 981556 HAT partially inhibited production of [TNF-alpha] and completely *inhibited* production of IL-4 , IL-5 , and . Negative_regulation TNF IL10 12535207 1049456 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL10 12535207 1049483 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL10 12754507 1093560 In macrophages lacking the Socs3 gene or carrying a mutation of the SOCS3 binding site in gp130 , the lipopolysaccharide induced production of [tumor necrosis factor (TNF)] and IL-12 is *suppressed* by both and IL-6 . Negative_regulation TNF IL10 1286062 207652 Furthermore , the production of IL-2 , interferon (IFN)-gamma , IL-6 , granulocyte macrophage colony stimulating factor , and [tumor necrosis factor-alpha] in primary MLCs was *diminished* by and enhanced in the presence of anti-IL-10 mAb . Negative_regulation TNF IL10 12960307 1138366 [TNF-alpha] production at elicitation sites was *down-regulated* by , a possible mediator produced by hapten-specific suppressor T cells that are generated by UV exposure . Negative_regulation TNF IL10 1429677 202680 Transforming growth factor (TGF)-beta and *inhibited* lipopolysaccharide (LPS) induced macrophage production of the inflammatory cytokines [tumor necrosis factor-alpha (TNF)] , IL-1 alpha , and IL-1 beta by contrasting post-transcriptional mechanisms . Negative_regulation TNF IL10 1429677 202689 not only *suppressed* [TNF] release to a 25-fold greater extent than TGF-beta , but also inhibited release of IL-1 . Negative_regulation TNF IL10 1429677 202693 Unlike TGF-beta , markedly *suppressed* [TNF] , IL-1 alpha , and IL-1 beta mRNA levels . Negative_regulation TNF IL10 14668613 1178139 Intrahepatic synthesis of [tumor necrosis factor-alpha] related to cardiac surgery is *inhibited* by via the Janus kinase (Jak)/signal transducers and activator of transcription ( STAT ) pathway . Negative_regulation TNF IL10 14688368 1190748 In agreement with the studies in STAT3-null mice , overexpression of the STAT3 DN completely reversed the ability of to *inhibit* LPS mediated [TNF-alpha] and IL-6 production . Negative_regulation TNF IL10 14754421 1205569 Thirdly , capsular polysaccharides enhance the production of anti-inflammatory and *induce* [tumor necrosis factor-alpha (TNFalpha)] receptor loss from the surface of neutrophils . Negative_regulation TNF IL10 14764735 1207398 Finally , exposure of macrophages to TLR ligands blocked the ability of to *inhibit* the induction of [TNF-alpha] by C2-ceramide . Negative_regulation TNF IL10 15039135 1272714 IL-22 did not affect *inhibition* of [tumor necrosis factor-alpha] in monocytes , which do not express IL-22R1 . Negative_regulation TNF IL10 15145612 1247725 Endogenous catecholamine , epinephrine and norepinephrine , and isoproterenol concentration-dependently induced the production of interleukin (IL)-18 , [tumor necrosis factor (TNF)-alpha] and interferon (IFN)-gamma , and *inhibited* that of in human peripheral blood mononuclear cells ( PBMC ) . Negative_regulation TNF IL10 15219461 1263915 Furthermore , both exogenous and PGE ( 2 ) *inhibit* LPS induced IL-6 and [TNF-alpha] , whereas selective inhibition of cyclooxygenase-2 (COX-2) or addition of anti-IL-10 causes the reverse effects . Negative_regulation TNF IL10 15292362 1278756 In contrast , choriodecidual production of IL-8 and [tumor necrosis factor (TNF)-alpha] was dramatically *inhibited* by , confirming the ability of this tissue to exhibit a classical IL-10 response . Negative_regulation TNF IL10 15293233 1278950 Results from these studies demonstrated a consistent *mediated* suppression of [TNF-alpha] ( 60 % +/- 2 % ) , IL-1beta ( 68 % +/- 3 % ) , CCL5 ( 62 +/- 4 % ) , but not CXCL10 production by HSV-1 infected microglial cells . Negative_regulation TNF IL10 15325406 1287148 significantly *reduced* IL-6 and [TNF-alpha] responses to TSST and staphylococcal enterotoxins A and C . Negative_regulation TNF IL10 15466252 1359215 Acute induction of *resulted* in significant decreases in bronchoalveolar lavage fluid neutrophils ( 48 % , P = 0.03 ) and [TNF] ( 62 % , P < 0.01 ) following intratracheal LPS compared with bitransgenic negative mice . Negative_regulation TNF IL10 16005735 1431290 Endogenous levels of *inhibited* the production of IL-12 , IFN-gamma , [TNF-alpha] , and IL-6 from both hematopoetic and non-hematopoetic cells in the brain , as well as anti-microbial activity of astrocytes . Negative_regulation TNF IL10 16226132 1469670 Garlic increases and *inhibits* [TNFalpha] and IL-6 production in endotoxin stimulated human placental explants . Negative_regulation TNF IL10 1627494 191737 Both IL-4 and [ cytokine synthesis inhibitory factor ( CSIF ) ] *inhibit* IL-2 induced synthesis of IFN-gamma and [tumor necrosis factor (TNF)-alpha] by human PBMC . Negative_regulation TNF IL10 1627494 191745 *inhibits* [TNF-alpha] synthesis by monocytes or monocytes plus NK cells , but not by NK cells alone . Negative_regulation TNF IL10 16275760 1480225 We further revealed the following three novel functional properties of OX40L : ( a) OX40L selectively promoted [TNF-alpha] , but *inhibited* production in developing Th2 cells ; Negative_regulation TNF IL10 16325368 1503414 Orientia tsutsugamushi *inhibits* [tumor necrosis factor] alpha production by inducing secretion in murine macrophages . Negative_regulation TNF IL10 16352613 1526361 Through kinetic analysis of the requirement for SOCS3 in *inhibition* of lipopolysaccharide (LPS) stimulated [tumor necrosis factor-alpha (TNFalpha)] transcription and translation , SOCS3 was found to be necessary for TNFalpha expression during the early phase , but not the late phase of IL-10 action . Negative_regulation TNF IL10 16352613 1526363 The SH2 domain , SOCS box , and both Tyr204 and Tyr221 were required for IL-10 inhibition of TNFalpha mRNA and protein expression , but interestingly the KIR domain was necessary only for *inhibition* of [TNFalpha] protein expression . Negative_regulation TNF IL10 16371225 1512436 The adenosine A(1) receptor antagonist inhibited TNF-alpha , IL-10 , and RANTES , adenosine A(2B) receptor antagonist inhibited [TNF-alpha] and RANTES , and adenosine A(3) receptor antagonist *inhibited* and RANTES . Negative_regulation TNF IL10 16380168 1533332 We tested the cytokine production of rat and mouse macrophages in vitro and found that internalization of SPIO/USPIO shifted macrophages towards an anti-inflammatory , less responsive phenotype by enhancing and *inhibiting* [tumor necrosis factor (TNF)-alpha] production . Negative_regulation TNF IL10 16461893 1522751 [TNF-alpha] was found to be more abundant in MKP-1-deficient macrophages within 2 hours of TLR stimulation , but its production was rapidly *down-regulated* by . Negative_regulation TNF IL10 1655948 166393 Although and v-IL-10 *suppressed* IL-1 alpha , IL-1 beta , [tumor necrosis factor alpha (TNF-alpha)] , and IL-6 production by monocytes , it was excluded that these cytokines played a role in antigen-specific T cell proliferation , since normal antigen-specific responses were observed in the presence of neutralizing anti-IL-1 , -IL-6 , and -TNF-alpha mAbs . Negative_regulation TNF IL10 16840796 1625279 Also , LPS induced cytokine secretion of [TNF] , IL-6 , and IL-12 was *enhanced* , whereas secretion of was strongly reduced after oxLDL preincubation . Negative_regulation TNF IL10 16865628 1613500 Because IL-10 is known to downregulate TNF-alpha , the increase in IL-10 and the decrease in TNF-alpha found among the CO2 insufflated animals in our study provide evidence for a mechanism whereby CO2 pneumoperitoneum reduces mortality via *mediated* downregulation of [TNF-alpha] . Negative_regulation TNF IL10 16888021 1596827 We previously reported that acute alcohol treatment augments and *inhibits* [TNF-alpha] production in monocytes . Negative_regulation TNF IL10 16888021 1596854 In LPS challenged mice in vivo , both acute alcohol administration and HO-1 activation augmented and *inhibited* [TNF-alpha] serum levels . Negative_regulation TNF IL10 17017555 1630064 significantly *inhibited* the microglial production of [tumor necrosis factor alpha (TNF-alpha)] , nitric oxide , ROS and superoxide free radicals after LPS stimulation . Negative_regulation TNF IL10 17045026 1635687 IL-7 and IL-15 could affect the balance between Th1 and Th2 cytokines by inducing IFN-gamma and [TNF-alpha] production and *inhibiting* IL-4 and expression . Negative_regulation TNF IL10 17082576 1643207 *prevents* the CD40 induced CTL and [TNF-alpha] and IL-12 production , Th1 skewing , and tumor regression . Negative_regulation TNF IL10 17302908 1699000 STAT3 activated by LPS did not directly regulate inhibitor of kappa B alpha ( IkappaBalpha ) activation or tumour necrosis factor (TNF)-alpha production , a process dependent on the transcriptional activity of nuclear factor kappa B (NFkappaB) , although the transcriptional activity of STAT3 contributed to the mechanism by which *suppressed* LPS induced [TNF-alpha] levels . Negative_regulation TNF IL10 17569361 1668970 In normal PBMC , emodin attenuated TNF-alpha and release in response to LPS , and SMI significantly *inhibited* [TNF-alpha] release . Negative_regulation TNF IL10 17592223 1768207 In contrast , acute alcohol treatment augmented NF-kappaB activation and [TNFalpha] production and *inhibited* levels in the presence of complex stimulation with combined TLR2 and TLR4 ligands . Negative_regulation TNF IL10 17690575 1781977 Elevated production by aged AIDS patients *contributed* considerably to control of HIV replication and to inhibition of [TNF-alpha] secretion but not to the reduced IFN-gamma production . Negative_regulation TNF IL10 17805009 1791260 The secretion of [tumor necrosis factor-alpha (TNF-alpha)] and IL-1beta elicited by UCB in astrocytes was *reduced* in the presence of GUDCA and , whereas the suppression of IL-6 was only counteracted by GUDCA . Negative_regulation TNF IL10 17948269 1819981 We also show that *induced* transcriptional repression of [TNF-alpha] and CXCL8 genes consists of two distinct phases : an early one , occurring rapidly and in a protein synthesis independent manner , followed by a second phase , more delayed and dependent on protein synthesis . Negative_regulation TNF IL10 18325328 1886209 A membrane proximal ITIM mutant of Siglec-9 did not enhance production but partly *inhibited* [TNF-alpha] production , indicating diverse regulation mechanisms of TNF-alpha and IL-10 . Negative_regulation TNF IL10 18383040 1893001 In the *presence* of , [TNF-alpha] production and activation of surface TACE was significantly inhibited . Negative_regulation TNF IL10 18641346 1937687 The results showed that deficiency *resulted* in significantly higher bacteremia , higher [TNF] levels , and early mortality . Negative_regulation TNF IL10 18679115 1955273 In model experiments with lipopolysaccharide stimulated human monocytes , recombinant human granulocyte colony stimulating factor and *reduced* the release of [tumor necrosis factor-alpha] by mean 30 % and 92 % , respectively . Negative_regulation TNF IL10 18679115 1955274 When plasmas from three shock patients were depleted of native granulocyte colony stimulating factor or interleukin-10 by immunoprecipitation , no increase in tumor necrosis factor-alpha release occurred after removal of granulocyte colony stimulating factor , whereas removal of *increased* the [tumor necrosis factor-alpha] release eight-fold . Negative_regulation TNF IL10 18707743 1961519 The 4 component system inhibited the production of the pro-inflammatory cytokine [tumor necrosis factor-alpha (TNF-alpha)] , and the Hp fraction *inhibited* the anti-inflammatory cytokine . Negative_regulation TNF IL10 18713727 1950746 *inhibits* [tumor necrosis factor-alpha] production in lipopolysaccharide stimulated RAW 264.7 cells through reduced MyD88 expression . Negative_regulation TNF IL10 18713727 1950747 The mechanism of *mediated* inhibition of [tumor necrosis factor (TNF)-alpha] production was studied by lipopolysaccharide (LPS) stimulated RAW 264.7 macrophage cells . Negative_regulation TNF IL10 18713972 1950817 In contrast , although apoptotic cells induced homogeneous IL-10 production by DCs , was not *necessary* for the inhibition of [TNF-alpha] and IL-12 . Negative_regulation TNF IL10 18845324 2021325 Conversely , recombinant dose-dependently *inhibited* Fc epsilon RI-mediated [TNF-alpha] responses up to 86 % +/- 3 % ( n = 3 , P < .001 ) . Negative_regulation TNF IL10 19014336 2022445 Phytohemagglutinin stimulation in combination with bovine CPC significantly increased the secretion of and IL-2 at 6 h of culture and *inhibited* IFN-gamma and [TNF] ( p < 0.05 ) . Negative_regulation TNF IL10 19050283 1999369 Likewise , expression of a dominant negative AMPKalpha1 in macrophages *enhanced* [TNF-alpha] and IL-6 protein synthesis in response to LPS stimulation , while diminishing the production of . Negative_regulation TNF IL10 19084112 2003533 Relm-alpha coactivated IL-6 and [TNF-alpha] release and *inhibited* release from LPS activated bone marrow derived macrophages . Negative_regulation TNF IL10 19164562 2032455 The presence of Gr-1 ( + ) neutrophils and elevated tumor necrosis factor-alpha (TNF-alpha) expression in colon were required for increased iNOS expression and cancer , whereas *down-regulated* [TNF-alpha] and iNOS expression and suppressed cancer . Negative_regulation TNF IL10 19232107 2040086 Primary cultures of murine macrophage and ovalbumin ( OVA ) specific T cells showed that whole mushroom extracts alone had no effect on cytokine production but co-stimulation with either lipopolysaccharide or OVA ( respectively ) *induced* [TNF-alpha] , IFN-gamma , and IL-1beta while decreasing . Negative_regulation TNF IL10 19383626 2100663 Further study showed that *reduced* [TNF] release in response to MTb in AM through a reduction in TNF mRNA levels , and exogenous TNF could partially reverse IL-10 associated effects on AM apoptosis . Negative_regulation TNF IL10 1940799 170633 , which has similar biological activities on human cells , also *inhibited* the production of [TNF alpha] and GM-CSF by monocytes following LPS activation . Negative_regulation TNF IL10 19410299 2128183 Zymosan enhanced dectin-1/TLR2/TLR4 expression and TNF-alpha/IL-10 production in all of three types of cell , whereas p-beta-glucan increased dectin-1/TLR4 and [TNF-alpha/IL-12] production in AMs but *inhibited* in mDCs . Negative_regulation TNF IL10 19428551 2077065 *inhibits* RANTES- , [tumour necrosis factor (TNF)-] and nerve growth factor (NGF) induced mast cell migratory response but is not a mast cell chemoattractant . Negative_regulation TNF IL10 19447494 2090732 The results indicate that mTOR dependent expression *leads* to inhibition of LPS induction of TF and the proinflammatory cytokine [TNFalpha] in WT macrophages . Negative_regulation TNF IL10 19528220 2121053 If pneumococcal LytA was inactivated by mutation or by culture in a medium containing excess choline , the pneumococci *induced* production of significantly more [TNF] , IFN-gamma , and IL-12 in PBMC , whereas the production of IL-6 , IL-8 , and was unaffected . Negative_regulation TNF IL10 19528220 2121065 Further , adding autolyzed pneumococci to intact bacteria inhibited production of [TNF] , IFN-gamma , and IL-12 in a dose dependent manner but did not *inhibit* production of IL-6 , IL-8 , and in response to the intact bacteria . Negative_regulation TNF IL10 19536644 2121136 On the contrary , SF from osteoarthritis patients did not favor osteoclastogenesis and exerted an anti-inflammatory effect through upregulation and [TNF-alpha] *inhibition* . Negative_regulation TNF IL10 19542371 2103691 In this study , we show that in LPS activated bone marrow derived murine macrophages , *reduces* the mRNA and protein levels of [TNF-alpha] and IL-1alpha in part through the RNA destabilizing factor tristetraprolin (TTP) . Negative_regulation TNF IL10 19714290 2175832 *inhibits* interferon gamma- and [tumor necrosis factor] alpha stimulated activation of NADPH oxidase 1 in human colonic epithelial cells and the mouse colon . Negative_regulation TNF IL10 20093775 2206124 from cDCs *reduced* production of [TNF] , IL-6 , and ROS by inflammatory monocytes . Negative_regulation TNF IL10 20180418 2180830 could relieve inflammatory infiltration of the prostate tissue and *inhibit* the expressions of [TNF-alpha] and TGF-beta1 in EAP rats , which is suggestive of its therapeutic efficacy for autoimmune prostatitis . Negative_regulation TNF IL10 20564507 2345400 Moreover , HSYA decreased NF-?B p65 nuclear translocation , *inhibited* proinflammatory cytokine [TNF-a] , IL-1ß and IL-6 mRNA expression and promoted antiinflammatory cytokine gene expression following LPS injection . Negative_regulation TNF IL10 20881185 2337360 Exosomes from Leishmania donovani modulated human monocyte cytokine responses to IFN-? in a bimodal fashion by promoting production and *inhibiting* that of [TNF-a] . Negative_regulation TNF IL10 21106642 2389902 transfer of WT but not ( -/- ) neutrophils into septic mice *reduced* monocyte expression of [TNF] . Negative_regulation TNF IL10 21140375 2378073 AC can be preferentially phagocytosed by KC in the liver , leading to attenuation of fulminant hepatitis through *mediated* suppression of KC-derived inflammatory [TNF-a] and NO production . Negative_regulation TNF IL10 21665577 2442722 Recombinant ( rIL10 ) has been found to *suppress* the synthesis of [tumour necrosis factor (TNF)] , interleukin-1 (IL-1) , interleukin-6 (IL-6) and tissue factor and to improve survival from experimental sepsis . Negative_regulation TNF IL10 21685693 2446436 overexpression *attenuated* expression of [TNF-a] and IL-1ß activated by lipopolysaccharide in astrocytes . Negative_regulation TNF IL10 21685693 2446438 [TNF-a] and IL-1ß were *inhibited* by overexpression in DI TNC1 actived by LPS . Negative_regulation TNF IL10 21968712 2617073 Overexpression of transforming growth factor ( TGF ) -ß ( 1 ) , but not , *resulted* in suppressed lipopolysaccharide (LPS) induced production of [TNF-a] and downregulation of TLR4 expression in L. donovani infected macrophages . Negative_regulation TNF IL10 22529524 2589641 Exogenous *inhibited* [TNF] , IL-6 , and IL-8 as secreted by day-2 infected cells . Negative_regulation TNF IL10 22576985 2696833 Using ELISA assays , lithium was demonstrated to *induce* production of pro-inflammatory cytokines , IL-6 and [TNF-a] , while inhibiting release of anti-inflammation related IL-2 and in a dose dependent fashion . Negative_regulation TNF IL10 22956783 2684021 Abundance of miR-181a attenuated ox-LDL induced CD83 and CD40 expression , *inhibited* the secretion of interleukin (IL)-6 and [TNF-a] , and up-regulated , an important anti-inflammatory cytokine that was inhibited by ox-LDL . Negative_regulation TNF IL10 23028901 2680704 It was found that interferon ( IFN ) -? was produced only by decidual immune cells ( DICs ) , and not by trophoblasts or decidual stromal cells ( DSCs ) ; all these cells secreted interleukin (IL)-4 , , and tumor necrosis factor (TNF)-a. Treatment with CsA completely blocked IFN-? production in DICs and *inhibited* [TNF-a] production in all examined cells . Negative_regulation TNF IL10 23071313 2694955 Accordingly , we identify miR-187 as an IL-10 dependent miRNA playing a role in *mediated* suppression of [TNF-a] , IL-6 , and the p40 subunit of IL-12 ( IL-12p40 ) produced by primary human monocytes following activation of Toll-like receptor 4 (TLR4) . Negative_regulation TNF IL10 23090044 2717164 Compared with group 2 , oxygenation index ( PaO ( 2 ) /FiO ( 2 ) ) , mean arterial pressure , serum amylase , and blood urine nitrogen showed significant differences ( all P < 0.01 ) and serum [TNF-a] , IL-1ß , IL-6 were *reduced* and was elevated with time in group 1 ( all P < 0.01 ) . Liver functions , electrolyte , and acid-base balance did not show significant difference before and after the 10-day treatment with CPFA plus CVVH compared with CVVH ( P > 0.05 ) . Negative_regulation TNF IL10 23256797 2718627 UA markedly rescued lethality , improved survival time and lung pathological changes , *inhibited* [TNF-a] , IL-6 , IL-1ß , HMGB1 and NO , and increased expression . Negative_regulation TNF IL10 23499643 2766631 Mechanistically , MSCs derived PGE2 , through the receptors EP2 and EP4 , promoted the release of and *inhibited* the production of IL-6 and [TNF-a] by macrophages . Negative_regulation TNF IL10 23602200 2783987 We found that *prevented* PMN activation and the secretion of [TNF-a] and IL-8 induced by the first LPS contact . Negative_regulation TNF IL10 23650073 2800701 Knockdown of miR-181 *enhanced* LPS induced production of pro-inflammatory cytokines ( [TNF-a] , IL-6 , IL-1ß , IL-8 ) and HMGB1 , while overexpression of miR-181 resulted in a significant increase in the expression of the anti-inflammatory cytokine . Negative_regulation TNF IL10 23703385 2792449 levels were elevated , but IL-1ß , IL-6 , and [tumor necrosis factor-alpha] ( TNF-a ) levels were *reduced* in the tumor tissues and spleens of IL-32ß mice , and athymic nude mice . Negative_regulation TNF IL10 23742617 2807060 Regarding the antinociceptive mechanisms of 1 , it prevented the decrease of reduced glutathione levels , ferric reducing ability potential , and free-radical scavenger ability , *inhibited* the production of hyperalgesic cytokines such as [TNF-a] , IL-1ß , IL-6 , and IL-33 , and up-regulated the levels of the anti-hyperalgesic cytokine . Negative_regulation TNF IL10 23904162 2830478 significantly *inhibited* LPS induced [TNF-a] production in both me/me and WT macrophages . Negative_regulation TNF IL10 23928112 2850063 Diaphragm and hindlimb muscles showed a rapid rise in interleukin-6 (IL-6) and mRNA and transient *inhibition* of [tumor necrosis factor-a (TNF-a)] and interleukin-1ß (IL-1ß) throughout early recovery , a pattern that parallels changes in circulating cytokines . Negative_regulation TNF IL10 24048901 2851781 Our findings suggest that activated platelets have anti-inflammatory properties related to the interaction between CD40L and CD40 , and exert a hitherto undescribed immunoregulatory action by enhancing production and *inhibiting* [TNF-a] production by monocytes . Negative_regulation TNF IL10 7508593 240147 TGF beta , IL-4 , and *inhibit* production of IL-1 and [TNF] . Negative_regulation TNF IL10 7572286 328889 In this study , we demonstrate that transforming growth factor-beta ( TGF-beta ) , and interleukin-6 (IL-6) *inhibit* [tumor necrosis factor-alpha] expression by primary rat astrocytes . Negative_regulation TNF IL10 7594490 334768 The sCD23 induced [TNF-alpha] production is significantly *inhibited* by IL-4 and but not by TGF-beta . Negative_regulation TNF IL10 7594556 334824 IL-10 production during endotoxic shock is part of a protective mechanism that involves *induced* inhibition of [TNF] synthesis . Negative_regulation TNF IL10 7604878 311718 Whereas recombinant *inhibited* the generation of [tumor necrosis factor-alpha (TNF-alpha)] and IL-1 beta by 90 and 60 % , respectively , it did not affect the formation of nitric oxide derived nitrite ( NO2- ) and nitrate ( NO3- ) . Negative_regulation TNF IL10 7658079 321447 *inhibits* [tumor necrosis factor] production but not antigen-specific lymphoproliferation in acute Plasmodium falciparum malaria . Negative_regulation TNF IL10 7673730 326004 In the spleen , IL-6 and [TNF-alpha] were *induced* by 30 min after LPS challenge , while increases in and IL-12 ( p40 ) were delayed in onset . Negative_regulation TNF IL10 7701586 297566 Treatment with IL-10 in vivo was found to diminish the capacity of splenocytes to produce IFN gamma when stimulated with LPS but not with Con A . did not protect GVH mice from a lethal dose of LPS but *caused* a marked reduction in the serum [TNF alpha] response triggered by the LPS challenge . Negative_regulation TNF IL10 7721885 301692 Our previous studies in human monocytes have demonstrated that *inhibits* lipopolysaccharide (LPS) stimulated production of inflammatory cytokines , IL-1 beta , IL-6 , IL-8 , and [tumor necrosis factor (TNF)-alpha] by blocking gene transcription . Negative_regulation TNF IL10 7804532 284668 IL-2 induced release of [TNF-alpha] was dramatically *reduced* by ; Negative_regulation TNF IL10 7852846 294751 IL-4 , , and IL-13 *suppressed* the generation of antitumor activity and cytokine production ( IL-1 beta and [TNF-alpha] ) of monocytes stimulated with MCAF plus norMDP or LPS . Negative_regulation TNF IL10 7897226 300032 Blocking of by Ab *resulted* in a 52 % increase in lung vascular permeability , a 56 % increase in [TNF-alpha] activity in bronchoalveolar lavage fluids , and a 47 to 48 % increase in bronchoalveolar lavage neutrophils and lung myeloperoxidase content . Negative_regulation TNF IL10 7930483 274684 The suppressive effect of prostaglandin E2 lasted for more than 36 h while *blocked* [tumor necrosis factor-alpha] production for barely 24 h. Dexamethasone reduced the endotoxin induced tumor necrosis factor-alpha mRNA formation by approximately 50 % only , although it led to nearly complete inhibition of the synthesis of the mature protein . Negative_regulation TNF IL10 7930949 275149 M-CSF and strongly *inhibited* [TNF] production at the level of both mRNA and bioactivity but had no effect on the production of IL-6 . Negative_regulation TNF IL10 7957562 278064 Further , IL-1 alpha stimulated production of [TNF-alpha] was *diminished* by and only a small proportion of this TNF-alpha was bioactive , consistent with increased production of inhibitory soluble TNF-R . Negative_regulation TNF IL10 7957562 278066 also *induced* down-regulation of surface p55 [TNF-R] on monocytes , and increased release of soluble p55 TNF-R . Negative_regulation TNF IL10 7957562 278068 , therefore , *reduces* the pro-inflammatory potential of TNF in three ways : by down regulating surface TNF-R expression whilst increasing production of soluble [TNF-R] and inhibiting the release of TNF-alpha itself . Negative_regulation TNF IL10 8097322 217601 We demonstrate that IFN-gamma production from SCID splenocytes is stimulated by interleukin (IL) 12 , tumor necrosis factor alpha (TNF-alpha) , and IL-2 but is *inhibited* by , IL-10 , IL-12 , and [TNF] are induced by heat killed Listeria monocytogenes ( hk-LM ) from SCID splenocytes and peritoneal macrophages . Negative_regulation TNF IL10 8245792 236940 As shown by Northern blot analysis , *diminished* the levels of [TNF] , IL-1 beta , and IL-8 mRNAs late after the onset of stimulation of PMN with LPS . Negative_regulation TNF IL10 8314354 249394 Recombinant and melanoma supernatants were found to *inhibit* production of [TNF-alpha] , IFN-gamma , IL-2 and mixed lymphocyte reactions but reversal of these effects of melanoma supernatants by MAbs against IL-10 was only seen in the case of TNF-alpha production . Negative_regulation TNF IL10 8426121 211066 and ( b ) inhibition of the delayed production of , an *inhibitor* of [TNF-alpha] and IL-1 beta synthesis . Negative_regulation TNF IL10 8426124 211068 *reduces* the release of [tumor necrosis factor] and prevents lethality in experimental endotoxemia . Negative_regulation TNF IL10 8426124 211069 We conclude that *inhibits* in vivo [TNF] secretion and protects against the lethality of endotoxin in a murine model of septic shock . Negative_regulation TNF IL10 8515073 221975 Stimulation of PBMC in the presence of neutralizing anti-IL-10 mAb indicated that endogenous production *inhibits* PBMC proliferation and release of [TNF-alpha] , GM-CSF , and IFN-gamma . Negative_regulation TNF IL10 8568303 349834 significantly *inhibited* [TNF-alpha] , IL-1 beta , and IL-6 production by M. avium infected monocytes . Negative_regulation TNF IL10 8610367 352875 We conclude that the 1 DR MM setting is associated with optimal secretion and more efficient *inhibition* of IFN-gamma and [TNF-alpha] compared with the 2 DR MM configuration . Negative_regulation TNF IL10 8613537 353548 We have observed that recombinant murine can *inhibit* the production of both IL-6 and [TNF-alpha] by mast cells without altering the degree of histamine release in response to anti-IgE . Negative_regulation TNF IL10 8641805 358553 In contrast , even at doses as high as 100 U/ml , *inhibited* [TNF-alpha] release in response to C. albicans by only 50 % . Negative_regulation TNF IL10 8646564 343020 *inhibits* lipopolysaccharide induced [tumor necrosis factor] and interleukin-1 beta production in the brain without affecting the activation of the hypothalamus-pituitary-adrenal axis . Negative_regulation TNF IL10 8666814 369120 Adenosine also significantly enhanced production after hydrogen peroxide and LPS stimulation and dose-dependently *inhibited* [TNF] secretion . Negative_regulation TNF IL10 8666814 369122 Blocking with anti-IL-10 mAbs partially *restored* adenosine induced [TNF] inhibition . Negative_regulation TNF IL10 8699123 372920 *inhibits* interleukin-2 induced [tumor necrosis factor] production but does not reduce toxicity in C3H/HeN mice . Negative_regulation TNF IL10 8699123 372924 However , did *inhibit* IL-2 induced increases in serum [TNF-alpha] , which was accompanied by a decrease in Golgi apparatus and rough endoplasmic reticulum in alveolar macrophages . Negative_regulation TNF IL10 8711645 371306 The lipopolysaccharide mediated [TNF-alpha] production in alveolar macrophages was *reduced* from 3.508 ( 0.629 ) to 2.035 ( 0.385 ) ng/ml by 100 U/ml . Negative_regulation TNF IL10 8742066 377132 LPS stimulated release of [TNF-alpha] declined substantially after the first day and was consistently *suppressed* by and IL-4 but increased by IFN-gamma . Negative_regulation TNF IL10 8805654 382281 In summary , significantly enhances the growth of L. pneumophila in human monocytes , reverses the protective effect of IFN-gamma , *blocks* [TNF-alpha] secretion , and is secreted by infected monocytes and alveolar macrophages . Negative_regulation TNF IL10 8818548 384678 *suppressed* IL-6 , IL-8 , [TNF-alpha] and GM-CSF production when added at the beginning of culture and added 24 h after incubation . Negative_regulation TNF IL10 8906217 394128 Blocking of endogenous substantially *increases* lung [TNF alpha] production , the recruitment of neutrophils , and the intensity of lung inflammatory injury . Negative_regulation TNF IL10 8957229 401592 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL10 9029140 413596 strongly *inhibited* LPS induced release of [TNF] , IL-6 , IL-8 , and IL-12 ( all p < 0.05 ) . Negative_regulation TNF IL10 9063693 418073 In the present study we addressed the question whether in combination with other TNF suppressing agents *leads* to enhanced suppression of [TNF] synthesis . Negative_regulation TNF IL10 9063693 418074 The maximal [TNF] synthesis of 5.5 +/- 1.1 ng/ml after lipopolysaccharide stimulation alone was *inhibited* by 0.1 ng/ml to 2.7 +/- 0.6 ng/ml TNF and by 100 nM rolipram to 3.1 +/- 0.6 ng/ml TNF . Negative_regulation TNF IL10 9086171 421506 The abilities of pentoxifylline and recombinant ( rIL-10 ) to *inhibit* [tumor necrosis factor (TNF)] and inducible nitric oxide synthase (iNOS) production in RAW 264.7 murine macrophages were compared . Negative_regulation TNF IL10 9122234 423960 After exposure to LPS , mRNA of interferon gamma , which sensitizes hepatocytes to TNF toxicity , is overexpressed , and mRNA levels of , a [TNF] *inhibitor* , are decreased . Negative_regulation TNF IL10 9160997 431825 Blocking of endogenous by neutralization with anti-IL-10 monoclonal antibody *resulted* in further augmented and prolonged secretion of [TNF-alpha] by both the fresh and frozen cells . Negative_regulation TNF IL10 9200315 439544 One of the *functions* of is to inhibit the [TNF alpha] production . Negative_regulation TNF IL10 9224418 442945 The anti-inflammatory cytokine *inhibits* both [TNF-alpha] and IL-1 , and we hypothesized that exogenous human IL-10 may decrease lung and soleus muscle injury after hindlimb I/R. Male Sprague-Dawley rats were randomly assigned to I/R ( n = 10 ) ; Negative_regulation TNF IL10 9271310 450253 In contrast , both PGE2 and *suppressed* LPS stimulated [TNF-alpha] production by AM and monocytes . Negative_regulation TNF IL10 9284853 451866 Recombinant human significantly *suppressed* production of the proinflammatory cytokines interleukin-1 beta and [tumor necrosis factor-alpha] by whole blood stimulated ex vivo with Escherichia coli lipopolysaccharide . Negative_regulation TNF IL10 9295017 453024 Furthermore , *inhibited* the production of IL-8 and [tumor necrosis factor-alpha] by DC when activated by LPS but not by CD40 . Negative_regulation TNF IL10 9359724 462245 Intravenous ( 1 mg/kg ) in two doses after intracisternal LOS significantly *reduced* CSF [TNF-alpha] and lactate . Negative_regulation TNF IL10 9369823 464063 and transforming growth factor-beta *inhibit* amniochorion [tumor necrosis factor-alpha] production by contrasting mechanisms of action : therapeutic implications in prematurity . Negative_regulation TNF IL10 9369823 464064 Lipopolysaccharide plus stimulation *resulted* in a dose dependent decrease in [tumor necrosis factor-alpha] messenger ribonucleic production ( transcriptional regulation ) to 6000 ( 50/50 ) and 600 ( 50/100 ) molecules . Negative_regulation TNF IL10 9373262 464786 Exogenously administered significantly *reduced* the IL-15 and IL-2 mediated IFN-gamma and [TNF-alpha] production , whereas T-cell proliferation and CD25 expression were not affected . Negative_regulation TNF IL10 9373262 464790 Inhibition of endogenous binding to the IL-10 receptor significantly *increased* IFN-gamma and [TNF-alpha] release from T cells . Negative_regulation TNF IL10 9378491 465563 *inhibited* PbA antigen-specific interferon-gamma (IFN-gamma) production in vitro but not [tumour necrosis factor (TNF)] serum levels in vivo . Negative_regulation TNF IL10 9378991 465726 Both constitutive and Ag-induced [TNF-alpha] production by PMC are dose-dependently *inhibited* by , whereas they are not affected by SCF at all doses tested ( 2-500 ng/ml ) and incubation times observed ( 3-24 h ) . Negative_regulation TNF IL10 9384233 466244 is an antiinflammatory cytokine and *inhibits* the production of [tumor necrosis factor] . Negative_regulation TNF IL10 9384233 466245 In view of its possible pharmacological use , we have now studied whether administered peripherally could *inhibit* brain [tumor necrosis factor] production . Negative_regulation TNF IL10 9415530 471967 subsequently *inhibits* [TNF-alpha] expression . Negative_regulation TNF IL10 9449707 483966 IL-18 did not induce antiinflammatory cytokines , IL-1Ra , or IL-10 , although IL-18 induction of [TNFalpha] was *inhibited* by . Negative_regulation TNF IL10 9473382 486382 Although *inhibits* PBMC induced proinflammatory IL-1alpha and [tumor necrosis factor-alpha] secretion , it had no major effect on IL-6 production . Negative_regulation TNF IL10 9498794 490642 CD137 protein induces expression of IL-6 , IL-8 , and [TNF-alpha] , and *inhibits* expression of . Negative_regulation TNF IL10 9603479 506808 *mediated* suppression of [TNF-alpha] production is independent of its ability to inhibit NF kappa B activity . Negative_regulation TNF IL10 9631245 512537 In this article , we describe the results of studies designed to determine the extent to which *contributes* to the suppression of [TNF-alpha] generation from LPS stimulated human monocytes evoked by 8-bromo cyclic AMP ( 8-Br-cAMP ) , rolipram , salbutamol , and prostaglandin E2 ( PGE2 ) . Negative_regulation TNF IL10 9631245 512538 Collectively , these data suggest that in contrast to murine hepatocytes and macrophages , does not *mediate* the inhibitory effect of cAMP elevating drugs on [TNF-alpha] generation from human monocytes . Negative_regulation TNF IL10 9717082 528055 Additionally , based on the kinetic analysis and further experiments described in the literature , endogenous could *contribute* to the adrenaline induced suppression of [TNF] synthesis after prolonged incubation . Negative_regulation TNF IL10 9758735 536322 In addition , also *reduced* [TNF] mRNA expression . Negative_regulation TNF IL10 9780204 540509 Exogenous also *inhibited* IL-12 and [TNF-alpha] production by chitin stimulated Mphi . Negative_regulation TNF IL10 9822893 548971 We have recently observed that the selective adenosine A3 receptor agonist N6- ( 3-iodobenzyl ) -adenosine-5'-N-methyluronamide ( IB-MECA ) augments and *inhibits* [tumor necrosis factor-alpha] production in endotoxemic mice . Negative_regulation TNF IL10 9834343 479667 *reduced* the serum levels of interleukin-1beta , interleukin-6 , [tumor necrosis factor-alpha] , and amylase in comparison to untreated animals with pancreatitis ( P < 0.05 ) . Negative_regulation TNF IL10 9872676 556929 *attenuated* LPS stimulated [TNF-alpha] production ( 297+/-54 ; p < .001 versus LPS alone ) . Negative_regulation TNF IL11 10564168 567153 Therefore , *prevents* LPS induced lung [TNF-alpha] production , neutrophil sequestration , and pulmonary vasomotor dysfunction . Negative_regulation TNF IL11 10623427 576182 In contrast , *reduced* the basal level by 18 % ( P < 0.005 ) and the TNF-alpha induced level of [TNF-R] by 51 % ( P < 0.01 ) as well as decreasing both TNF-sR55 and TNF-sR75 . Negative_regulation TNF IL11 10813532 693299 In the *presence* of , IL-3 , SLF , and Tpo , CFU-MK derived from CB , mPBL , and BM was suppressed by [tumor necrosis factor-alpha (TNF-alpha)] and transforming growth factor-beta1 ( TGF-beta1 ) . Negative_regulation TNF IL11 12535207 1049457 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL11 12535207 1049484 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL11 8957229 401593 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL11 9704636 525584 Addition of exogenous IL-11 inhibited spontaneous [TNFalpha] production in RA synovium only in the *presence* of soluble receptor . Negative_regulation TNF IL12A 17058806 1636891 IL-1beta alone significantly induced IL-12 production in DCs , whereas [TNF-alpha] or IFN-gamma *induced* modest levels of production . Negative_regulation TNF IL12A 21150712 2366394 In the *presence* of , CTL differentiation toward lytic function is not accompanied by a reduction in the secretion of interferon-? and [tumor necrosis factor-a] . Negative_regulation TNF IL12A 21764089 2599148 The findings suggested that CSFV infection significantly increased the mRNA expression of IL-10 and [TNF-a] , and *inhibited* expression , with little effect on IFN-a and IFN-? expression . Negative_regulation TNF IL12A 21830095 2495573 Tacrolimus completely inhibited IFN-? and [TNF-a] production of activated T-cells in LPMCs , but only partially *inhibited* IFN-? , TNF-a , and production of activated monocytes/macrophages in LPMCs . Negative_regulation TNF IL12A 7673730 326005 In the spleen , IL-6 and [TNF-alpha] were *induced* by 30 min after LPS challenge , while increases in IL-10 and ( p40 ) were delayed in onset . Negative_regulation TNF IL12B 17058806 1636892 IL-1beta alone significantly induced IL-12 production in DCs , whereas [TNF-alpha] or IFN-gamma *induced* modest levels of production . Negative_regulation TNF IL12B 21150712 2366395 In the *presence* of , CTL differentiation toward lytic function is not accompanied by a reduction in the secretion of interferon-? and [tumor necrosis factor-a] . Negative_regulation TNF IL12B 21764089 2599149 The findings suggested that CSFV infection significantly increased the mRNA expression of IL-10 and [TNF-a] , and *inhibited* expression , with little effect on IFN-a and IFN-? expression . Negative_regulation TNF IL12B 21830095 2495574 Tacrolimus completely inhibited IFN-? and [TNF-a] production of activated T-cells in LPMCs , but only partially *inhibited* IFN-? , TNF-a , and production of activated monocytes/macrophages in LPMCs . Negative_regulation TNF IL12B 7673730 326006 In the spleen , IL-6 and [TNF-alpha] were *induced* by 30 min after LPS challenge , while increases in IL-10 and ( p40 ) were delayed in onset . Negative_regulation TNF IL13 10569696 568021 Both IL-4 and significantly *inhibited* [TNF] induced IL-6 release ( P < 0.01 for both ) while augmenting the effect of IFNgamma ( P < 0.005 and P < 0.01 , respectively. ) . Negative_regulation TNF IL13 10903807 713239 Even though *reduced* [TNF-alpha] secretion by 50 % , this did not impair NF-kappa B activation in IFN-gamma treated cells infected with HSV-2 . Negative_regulation TNF IL13 12082286 958527 Similarly , significantly *inhibits* lipopolysaccharide (LPS) induced [TNF-alpha] production by mononuclear cells from peripheral blood , but not in cells from inflamed synovial fluid . Negative_regulation TNF IL13 12082286 958528 In OA synovial membranes treated with LPS , *inhibited* the synthesis of IL-1beta , [TNF-alpha] and stromelysin , while increasing IL-1Ra production . Negative_regulation TNF IL13 12535207 1049458 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL13 12535207 1049485 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL13 12670721 1076154 Both IL-4 and *inhibit* the [TNF-alpha] and IFN-gamma enhanced MDC production in a human keratinocyte cell line , HaCaT cells . Negative_regulation TNF IL13 12670721 1076160 Both interleukin-4 (IL-4) and *inhibited* [TNF-alpha] and IFN-gamma enhanced MDC production in HaCaT cells in a dose dependent manner . Negative_regulation TNF IL13 12960356 1138457 We found that and IL-4 *inhibited* [TNF-alpha-] and IFN-gamma induced HBD-3 production . Negative_regulation TNF IL13 21144661 2396164 In the abomasum , increased and [TNF-a] was *down-regulated* ( p < 0.05 ) . No differences were detected for mast cells and eosinophil counts in abomasal tissue ( p > 0.05 ) . Negative_regulation TNF IL13 23351078 2769918 IL-4 and *inhibit* IL-1ß and [TNF-a] induced kinin B1 and B2 receptors through a STAT6 dependent mechanism . Negative_regulation TNF IL13 23554645 2367184 Recombinant *inhibited* [tumor necrosis factor-a (TNF-a)] , IL-1a , IL-1ß , monocyte chemoattractant protein-1 ( MCP-1 ) , IL-8 , and transforming growth factor-ß1 ( TGF-ß1 ) mRNA expressions in a dose dependent manner . Negative_regulation TNF IL13 7533678 296868 significantly *inhibited* lipopolysaccharide (LPS) induced [tumour necrosis factor-alpha (TNF-alpha)] production by mononuclear cells from peripheral blood , but not synovial fluid . Negative_regulation TNF IL13 7852846 294752 IL-4 , IL-10 , and *suppressed* the generation of antitumor activity and cytokine production ( IL-1 beta and [TNF-alpha] ) of monocytes stimulated with MCAF plus norMDP or LPS . Negative_regulation TNF IL13 7902377 234592 Furthermore , *inhibited* production of IL-1 alpha , IL-1 beta , IL-6 , IL-8 , IL-10 , IL-12 p35 , IL-12 p40 , macrophage inflammatory protein-1 alpha , granulocyte/macrophage-CSF , granulocyte-CSF , IFN-alpha , and [TNF alpha] by monocytes activated with LPS . Negative_regulation TNF IL13 7911424 257833 markedly *suppressed* nitric oxide release and to a lesser extent secretion of the pro-inflammatory cytokine [tumor necrosis factor-alpha] . Negative_regulation TNF IL13 8957229 401594 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL13 9162077 431913 The production of [tumor necrosis factor-alpha (TNF-alpha)] by lipopolysaccharide (LPS) stimulated macrophages can be markedly *inhibited* by the two closely related cytokines , interleukin (IL)-4 and . Negative_regulation TNF IL13 9200476 439616 *inhibits* [TNF] production but potentiates that of IL-6 in vivo and ex vivo in mice . Negative_regulation TNF IL13 9521071 493705 human gene transfer *reduced* serum [TNF-alpha] levels by 90 % ( 113.1 pg/ml to 11.6 pg/ml ; p < 0.05 ) . Negative_regulation TNF IL13 9616438 509623 In OA synovial membrane treated with LPS , *inhibited* the synthesis of IL-1 beta , [TNF-alpha] and stromelysin-1 , but increased IL-1Ra production . Negative_regulation TNF IL15 11919076 926003 Here we demonstrate that , in the presence or absence of [tumor necrosis factor (TNF)-alpha] , *reduces* spontaneous apoptosis in freshly isolated human eosinophils . Negative_regulation TNF IL15 12535207 1049459 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL15 12535207 1049486 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL15 8957229 401595 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL15 9376592 465510 The reduced production of from CB MNCs in response to stimulation may *contribute* to the decrease in IFN-gamma and [TNF-alpha] production and CB cellular immunity . Negative_regulation TNF IL16 12535207 1049460 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL16 12535207 1049487 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL16 16178875 1458221 is *involved* in the regulation of the expression of several proinflammatory cytokines , i.e . [tumour necrosis factor (TNF)alpha] and interleukin (IL)-1beta . Negative_regulation TNF IL16 8957229 401596 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL17A 11588011 866557 Moreover , overexpression of in the pulmonary compartment using a recombinant adenovirus encoding murine IL-17 ( AdIL-17 ) *resulted* in the local induction of [tumor necrosis factor-alpha] , IL-1beta , macrophage inflammatory protein-2 , and granulocyte colony stimulating factor ( G-CSF ) ; Negative_regulation TNF IL17A 18477039 1921617 stimulation also *resulted* in the production of [TNF-alpha] . Negative_regulation TNF IL17A 19815670 2164498 IL-17A protein was detected in approximately 40 % of the supernatants and blockade , in IL-17A producing cultures , *resulted* in a small but significant inhibition of [TNF-alpha] ( 38 % ) , IL-1beta ( 23 % ) and IL-6 ( 22 % ) . Negative_regulation TNF IL17D 15749890 1379744 In vitro , induced STAT3 phosphorylation and *inhibited* [TNF] and IL-12 production in activated peritoneal macrophages , indicating a novel feedback mechanism by which IL-27 can modulate excessive inflammation . Negative_regulation TNF IL17D 20468050 2258000 *inhibits* OSM mediated [TNF-alpha] and iNOS gene expression in microglia . Negative_regulation TNF IL18 10217305 608374 inhibits the LPS induced release of IL-12 and *attenuates* that of [TNF-alpha] , whereas the production of IL-6 and macrophage inflammatory protein-1alpha is only marginally affected . Negative_regulation TNF IL18 11748266 889589 In vitro , neutralizing *resulted* in a significant inhibition of [TNF-alpha] , IL-6 , and IFN-gamma secretion by macrophages . Negative_regulation TNF IL18 11883701 919688 *reduces* expression of cardiac [tumor necrosis factor-alpha] and atrial natriuretic peptide in a murine model of viral myocarditis . Negative_regulation TNF IL18 12535207 1049461 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL18 12535207 1049488 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL18 15936988 1440452 In the *presence* of , simvastatin suppressed the expression of ICAM-1 and CD40 as well as the production of IL-12 , [TNF-alpha] and IFN-gamma in PBMC , contributing to the anti-inflammatory effect of simvastatin . Negative_regulation TNF IL18 8957229 401597 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL18BP 12670445 1076018 S. epidermidis induced [TNF-alpha] was *inhibited* by and IL-1Ra , but not anti-IL-12 Ab , whereas IL-8 production was unaffected by any of the specific cytokine blocking agents . Negative_regulation TNF IL19 12535207 1049462 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL19 12535207 1049489 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL19 8957229 401598 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL1A 10433877 634175 We therefore investigated whether *mediated* inhibition of [TNF-alpha] secretion from astrocytes by RGAE . Negative_regulation TNF IL1A 10473176 642113 We therefore examined whether *mediated* inhibition of [TNF-alpha] production from primary astrocytes by CmT . Negative_regulation TNF IL1A 10783913 580154 While serum activity was elevated throughout the 3-day period of observation , the levels of serum [TNF] activity were *enhanced* after 12 h and on days 1 and 3 following scalding injury . Negative_regulation TNF IL1A 10946829 721621 We therefore examined whether *mediated* inhibition of [TNF-alpha] production from primary astrocytes by TO . Negative_regulation TNF IL1A 11322653 807163 We therefore examined whether *mediated* inhibition of [TNF-alpha] secretion from primary astrocytes by Chilbokeum . Negative_regulation TNF IL1A 11686517 875868 Moreover , we demonstrated that M. furfur modulates proinflammatory and immunomodulatory cytokine synthesis by downregulating and by *inhibiting* IL-6 and [TNF-alpha] and by upregulating IL-10 and TGF-beta1 . Negative_regulation TNF IL1A 11807961 906411 We therefore examined whether *mediated* inhibition of [TNF-alpha] secretion from primary astrocytes by Sesim-Tang . Negative_regulation TNF IL1A 12164270 972671 We therefore examined whether *mediated* inhibition of [TNF-alpha] secretion from primary astrocytes by SSGP . Negative_regulation TNF IL1A 1429677 202690 IL-10 not only suppressed [TNF] release to a 25-fold greater extent than TGF-beta , but also *inhibited* release of . Negative_regulation TNF IL1A 15972642 1424017 The cytokines TNF-alpha or IL-1beta , but not IL-6 , mimicked the cytotoxic effect of LPS , whereas blocking either [TNF-alpha] with a neutralizing Ab or with recombinant antagonist *prevented* LPS cytotoxicity . Negative_regulation TNF IL1A 19055838 2001743 [TNF] release from LPS stimulated human peripheral blood mononuclear cells was inhibited with IC50s 16 +/- 6 nM and 14 +/- 8 nM , ( mean +/- S.D. ) for SB-203580 and VX-745 and was *inhibited* with IC50s of 20 +/- 8 nM and 15 +/- 4 nM ( mean +/- S.D. ) , respectively . Negative_regulation TNF IL1A 20737183 2363503 The LLLT not altered expression in any time , but *reduced* the [TNF-a] expression ; Negative_regulation TNF IL1A 21833523 2658043 In response to mild hypothermia , an enhanced expression by patient monocytes *resulted* in increased IL-6 and [TNF-a] secretion , as compared to control cells . Negative_regulation TNF IL1A 23494261 2853784 Propofol modulates acute AQP-4 expression by attenuating IL-1ß and [TNF-a] expression and *inhibiting* and TNF-a induced AQP-4 expression . Negative_regulation TNF IL1A 23567618 2794563 Mitogen activated protein/extracellular signal regulated kinase inhibitor U0126 abrogated [TNF-a-] , IFN-?- , and induced and Janus activated kinase inhibitor I *reduced* IFN-? induced IL-33 production . Negative_regulation TNF IL1A 24490798 2913634 Ilantide bound IL-1RI , *inhibited* the induced activation of NF-?B , and inhibited the secretion of [TNF-a] in vitro . Negative_regulation TNF IL1A 2496917 109697 The purpose of this study was to determine if recombinant murine interleukin 1 beta ( rMu-IL-1 beta ) alone or in combination with recombinant murine gamma-interferon ( rMu-IFN-gamma ) could activate murine macrophages to be tumoricidal against tumor necrosis factor (TNF)-insensitive target cells and to evaluate the possible *role* of in murine macrophage activation by recombinant murine tumor necrosis factor ( [rMu-TNF] ) plus rMu-IFN-gamma . Negative_regulation TNF IL1A 3330009 83504 similarly , and IL-1 beta induce reciprocal tachyphylaxis but do not *inhibit* [TNF] or LT . Negative_regulation TNF IL1A 7600192 311505 LPS1 significantly increased LPS2 triggered monocyte secretion of , IL-6 , and PGE2 , but *inhibited* [TNF] release . Negative_regulation TNF IL1A 7928001 273986 However , the ability of monocytes in PBM to produce [TNF-alpha] was significantly *enhanced* 5 days after the drug administration , although and IL-1-beta production was not augmented . Negative_regulation TNF IL1A 7989596 282863 To investigate the contribution of IL-1 , IL-6 , and TNF to the increased osteoclastogenesis induced by estrogen deficiency , ovariectomized ( ovx ) mice were treated with either IL-1 receptor antagonist (IL-1ra) , a competitive inhibitor of , TNF binding protein (TNFbp) , an *inhibitor* of [TNF] , or the anti-IL-6 antibody ( Ab ) 20F3 for the first 2 wk after surgery . Negative_regulation TNF IL1A 8586485 337522 Associated with these improvements in organ dysfunction and survival was a modest decrease in LPS stimulated and interleukin-1 beta (IL-1 beta) secretion and a marked ( > 90 % ) *inhibition* of [TNF] secretion by MDL 101,002 . Negative_regulation TNF IL1A 8757625 377750 The bidirectional effects of TNF-alpha on hematopoietic growth factor induced survival of hematopoietic progenitors were reflected in that TNF-alpha enhanced apoptosis of Lin- Sca-1+ cells when combined with SCF , whereas [TNF-alpha] synergistically suppressed apoptosis in *response* to . Negative_regulation TNF IL1A 9089293 421817 Besides demonstration of this novel mechanism of IL-1 stimulated TNF-alpha expression , our data indicate an important *role* of in [TNF-alpha] production of cytotrophoblastic cells . Negative_regulation TNF IL1A 9541129 498040 The three drugs did not decrease IL-6 and IL-8 secretion by colonic biopsies , whereas they did *inhibit* and , to some degree , [TNF] production . Negative_regulation TNF IL1A 9705011 525646 We therefore also investigated whether *mediated* inhibition of [TNF-alpha] secretion from primary astrocytes by PTAE . Negative_regulation TNF IL1A 9730251 530249 We therefore investigated whether *mediated* inhibition of [TNF-alpha] secretion from astrocytes by ACAE . Negative_regulation TNF IL1B 10224371 610182 In addition , Ro 31-8220 ( a PKC inhibitor ) inhibited OX8 induced iNOS upregulation , NO and production , but did not *inhibit* [TNF-alpha] production . Negative_regulation TNF IL1B 10419651 632070 *mediates* the effect of high D-glucose on the secretion of [TNF-alpha] by mouse uterine epithelial cells . Negative_regulation TNF IL1B 10532635 562345 To investigate the *role* of in regulation of [tumor necrosis factor-alpha (TNF-alpha)] and intercellular adhesion molecule-1 ( ICAM-1 ) during focal cerebral ischemia , the authors studied mutant mice deficient in the IL-1 converting enzyme (ICE) gene ( ICE knockout [ KO ] mice ) . Negative_regulation TNF IL1B 10893209 711344 However , the LPS effects on [TNF-alpha] and IL-8 are *inhibited* by < 20 % and the effect on by < 50 % . Negative_regulation TNF IL1B 15893771 1419775 At 200 ng/ml [TNFalpha] , SOCS3 mRNA levels were increased , but significantly *reduced* in the presence of or IL-6 ( P < 0.05 ) . Negative_regulation TNF IL1B 15916742 1412859 Furthermore , MT-Se significantly lowered an increase in [TNF-alpha] and IL-1beta levels in the liver and *inhibited* the production of TNF- alpha and by peritoneal macrophages . Negative_regulation TNF IL1B 16011257 1431560 Ginkgolide B was shown to significantly inhibit angiogenesis of the murine chronic granulomatous air pouch model , reduce the and TNF-alpha levels in mice serums , and significantly *inhibit* IL-1beta and [TNF-alpha] mRNA expression and protein secretion in supernatants of U937 cell culture . Negative_regulation TNF IL1B 16202497 1500967 All the tested hardwood and softwood dusts induced [TNF-alpha] expression and *inhibited* expression . Negative_regulation TNF IL1B 17618462 1774998 The expressions were inhibited by ketotifen in the two strains , but [TNF-alpha] expression was *inhibited* in the C3H/HeN mice after ketotifen treatment . Negative_regulation TNF IL1B 18480275 1910664 Consistently , [TNFalpha] and IL-1beta enhanced AMPA- or NMDA induced currents , and and IL-6 *suppressed* GABA- and glycine induced currents . Negative_regulation TNF IL1B 19046141 1999002 P4 enhanced the production of and IL-8 , but *inhibited* [TNF-alpha] production by monocytes stimulated with either organism . Negative_regulation TNF IL1B 20712904 2317874 Resveratrol inhibited LPS induced expression and release of [TNF-alpha] , IL-6 , MCP-1 , and iNOS/NO in both cell types with more potency in microglia , and *inhibited* LPS induced expression of in microglia but not astrocytes . Negative_regulation TNF IL1B 2784408 109020 Rabbit and anti-TNF alpha specifically neutralized both proliferation and PGE2 production induced by these monokines , but anti-IL-1 beta ( or anti-IL-1 alpha ) did not *block* [TNF alpha] activity . Negative_regulation TNF IL1B 3330009 83505 similarly , IL-1 alpha and induce reciprocal tachyphylaxis but do not *inhibit* [TNF] or LT . Negative_regulation TNF IL1B 7680648 211626 IL-4 down-regulated and IFN gamma *enhanced* the [TNF alpha-] and IL-1 beta induced increase in RANTES mRNA , whereas the induction of IL-8 mRNA by TNF alpha or was inhibited by IFN gamma and augmented by IL-4 . Negative_regulation TNF IL1B 7928001 273987 However , the ability of monocytes in PBM to produce [TNF-alpha] was significantly *enhanced* 5 days after the drug administration , although IL-1-alpha and production was not augmented . Negative_regulation TNF IL1B 8048000 267089 Enhanced survival from cecal ligation and puncture with pentoxifylline is associated with altered neutrophil trafficking and reduced expression but not *inhibition* of [tumor necrosis factor] synthesis . Negative_regulation TNF IL1B 8574153 342203 PAI was able to *induce* the production of IFN-gamma and [TNF-alpha] while that of IL-4 and was reduced . Negative_regulation TNF IL1B 8586485 337523 Associated with these improvements in organ dysfunction and survival was a modest decrease in LPS stimulated interleukin-1 alpha (IL-1 alpha) and secretion and a marked ( > 90 % ) *inhibition* of [TNF] secretion by MDL 101,002 . Negative_regulation TNF IL1B 8840155 386688 The data provide evidence for an in vivo *role* for epidermal IL-1 alpha , and TNF-alpha transcription in the regulation of IL-1 beta and [TNF-alpha] polypeptide levels in the epidermis in response to this common contact allergen . Negative_regulation TNF IL1B 9266282 449459 Benzydamine ( 6.25-50 microM ) *inhibited* Candida induced [tumor necrosis factor-alpha] and , to a lesser extent , production , whereas it did not affect interleukin-6 release . Negative_regulation TNF IL1B 9357863 462085 In contrast , TIMP-1 production evaluated by immunoblotting was unchanged in the *presence* of LPS and and was clearly decreased in the presence of [TNF-alpha] . Negative_regulation TNF IL1B 9357863 462087 Quantitative RT-PCR demonstrated that TIMP-1 mRNA levels remained unchanged in *response* to LPS or but decreased by 70 % in the presence of [TNF-alpha] . Negative_regulation TNF IL1B 9397943 291196 alone in concentrations of 0.1 , 1 and 10 ng/ml inhibited testosterone formation by 45 % , 62 % and 91 % , respectively , in the presence of [TNF-alpha] ( 10 ng/ml ) , IL-1beta in a concentration as low as 0.1 ng/ml completely *blocked* hCG induced testosterone formation . Negative_regulation TNF IL1B 9510167 491838 appears to mediate the inhibitory actions of TNF + LPS on beta cell function as TNF + LPS induced expression of IL-1beta is fourfold higher than IL-1alpha , and Ab neutralization of IL-1beta *prevents* [TNF] + LPS induced nitrite production by rat islets . Negative_regulation TNF IL1R2 17182252 1688329 gene transfer *reduced* intragraft monocytes/macrophages and CD4 ( + ) cell infiltrates ( p < 0.05 ) , [TNF-alpha] and transforming growth factor-beta ( TGF-beta ) expression ( p < 0.05 ) , and prolonged graft survival ( 15.6+/-5.7 vs 10.3+/-2.5 days with control vector and 10.1+/-2.1 days with buffer alone ; p < 0.01 ) . Negative_regulation TNF IL1RN 12670445 1076019 S. epidermidis induced [TNF-alpha] was *inhibited* by IL-18BP and , but not anti-IL-12 Ab , whereas IL-8 production was unaffected by any of the specific cytokine blocking agents . Negative_regulation TNF IL1RN 14566449 1165134 Interestingly , both , the IL-1beta- and [TNFalpha-effect] could be *blocked* by , indicating that also the TNFalpha induced RGS16 expression is mediated by IL-1 . Negative_regulation TNF IL1RN 1533322 186457 At a twofold molar excess , *inhibited* IL-1 induced IL-1 or [TNF alpha] synthesis by 50 % ( P less than .01 ) ; Negative_regulation TNF IL1RN 16209246 1464388 ( IL-1ra ) and tumor necrosis factor soluble receptors ( sTNFR ) type I and II *reducing* the activity of IL-1 and [TNFalpha] may inhibit inflammatory reactions . Negative_regulation TNF IL1RN 16369129 1553929 Levels of the interleukin-1 receptor antagonist ( ) , the soluble [tumor necrosis factor] receptor *inhibitor* ( sTNF-p55 ) and G-CSF were measured by ELISA . Negative_regulation TNF IL1RN 18389438 1893231 Lycopene *induced* a dose dependent increase in IL1beta , and [TNFalpha] production and a decrease in IL-2 , IL-10 and IFNgamma secretion , whereas that of IL-6 and was not affected . Negative_regulation TNF IL1RN 20003323 2176609 Lewis rats with established AIA or CIA were treated for 10 days ( from day 4 post onset ) with either PBS ( Veh ) , [TNFalpha] *inhibitor* ( pegsunercept ) , IL-1 inhibitor ( ) , or RANKL inhibitor ( osteoprotegerin (OPG)-Fc ) . Negative_regulation TNF IL1RN 22675954 2611444 The production of IL-8 was significantly increased by IL-1alpha or [TNF-alpha] , and the increase of IL-8 stimulated by IL-1alpha was *suppressed* by in a dose dependent manner . Negative_regulation TNF IL1RN 22718926 2616420 Biologic treatments -- including five [TNF-a] *inhibitors* , the IL-1 receptor antagonist , the IL-6 receptor inhibitor tocilizumab , the selective inhibitor of T-cell co-stimulation abatacept and the B-cell directed mAb rituximab -- have provided effective therapeutic options for patients with RA with inadequate response to conventional DMARDs . Negative_regulation TNF IL1RN 23842733 2820989 These results indicate that the release of from BMSCs via paracrine mechanisms significantly *blocks* the production and/or activity of IL-1 and [TNF-a] . Negative_regulation TNF IL1RN 3040855 77464 In contrast , human recombinant [tumor necrosis factor] , which shares some of the biologic activities of IL-1 , is not *inhibited* by the urinary . Negative_regulation TNF IL1RN 8048540 267136 Alveolar macrophages demonstrated variable *induced* suppression of LPS stimulated IL-1 beta and [TNF-alpha] release . Negative_regulation TNF IL1RN 8144913 252557 at concentrations achieved in the plasma during IL-2 immunotherapy ( approximately 10 ng/ml ) *inhibited* the in vitro production of IL-1 beta and [TNF-alpha] by IL-2 activated PBMCs by 65 % and 30 % , respectively . Negative_regulation TNF IL1RN 8348747 227045 In this study , the production of cytokines IL-1 beta , [tumour necrosis factor-alpha (TNF-alpha)] , IL-6 and the naturally occurring *inhibitor* of IL-1 , , have been investigated in infants and children undergoing Swenson 's pull-through operation for Hirschsprung 's disease . Negative_regulation TNF IL1RN 8594005 342023 Exercise *induced* a decrease of LPS stimulated production of IL-1 beta and [TNF-alpha] , whereas production of was unchanged . Negative_regulation TNF IL2 10477536 643018 The 14-day survival in mice treated with rhIL-10 was significantly higher ( 80 % ) than in the control group ( 30 % , n=10 in each , P < 0.05 ) . rhIL-10 treatment significantly attenuated myocardial lesions and *suppressed* [tumor necrosis factor-alpha] and in the heart. rhIL-10 treatment had little effect on myocardial virus concentration . Negative_regulation TNF IL2 11377186 820170 In order to assess the immunological activity , the prodrugs were tested using [tumor necrosis factor-alpha] and *inhibition* assays . Negative_regulation TNF IL2 12022445 943272 YH-Tang significantly inhibited interleukin (IL)-1 , IL-4 , IL-6 and [tumor necrosis factor-alpha (TNF-alpha)] secretion in astrocytes stimulated with SP and LPS , but did not *inhibit* interferon-y ( IFN-gamma ) and secretion significantly . Negative_regulation TNF IL2 12535207 1049463 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL2 12535207 1049490 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL2 12781508 1095681 In general , most fluoroquinolone derivatives superinduce in-vitro synthesis but *inhibit* synthesis of interleukin 1 and [tumour necrosis factor (TNF)alpha] ; Negative_regulation TNF IL2 1353987 192646 Anti-CD3 induced TNF-alpha production could be inhibited by blocking the IL-2R with a combination of anti-Tac and Mik beta 1 ( mAbs against the p55 and p75 chain of the IL-2R respectively ) thus indicating an essential *role* of in [TNF-alpha] induction . Negative_regulation TNF IL2 16314006 1526170 Specific IgG prevents enteroinvasive Escherichia coli/Salmonella typhi induced diarrhea and may exert an effective protection by enhancing splenic NK cell activity , elevating level and *inhibiting* excessive release of [TNF-alpha] in mice . Negative_regulation TNF IL2 17523134 1762095 This reduction was dose and time dependent , suggesting a regulatory *role* of in [TNF] secretion that might occur at the post-transcriptional level . Negative_regulation TNF IL2 19014336 2022439 The addition of LPS to PBMCs cocultured with bovine CPC significantly stimulated the release of and *inhibited* the early release of [TNF] , IL-6 , and IL-4 ( p < 0.02 ) . Negative_regulation TNF IL2 19014336 2022446 Phytohemagglutinin stimulation in combination with bovine CPC significantly increased the secretion of IL-10 and at 6 h of culture and *inhibited* IFN-gamma and [TNF] ( p < 0.05 ) . Negative_regulation TNF IL2 19589546 2208823 The attenuated acute rejection with decreased apoptosis of hepatocytes and *reduced* cytokine production of IL-2 , [tumor necrosis factor-alpha (TNF-alpha)] , and interferon-gamma (IFN-gamma) in the graft . Negative_regulation TNF IL2 19762486 2168296 Stimulation of CD56+ cells containing both DCs and abundant gammadelta T cells with zoledronate and *resulted* in the rapid expansion of gammadelta T cells as well as in IFN-gamma , [TNF-alpha] , and IL-1beta but not in IL-4 , IL-10 , or IL-17 production . Negative_regulation TNF IL2 22576985 2696834 Using ELISA assays , lithium was demonstrated to *induce* production of pro-inflammatory cytokines , IL-6 and [TNF-a] , while inhibiting release of anti-inflammation related and IL-10 in a dose dependent fashion . Negative_regulation TNF IL2 2442261 76939 [TNF-alpha] , like IL-1 beta , *induced* increased levels of expression on YT cells with similar kinetics of induction . Negative_regulation TNF IL2 8957229 401599 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL2 9504629 491271 Mitogenic stimulation with phorbol 12-myristate 13-acetate ( PMA ) or PMA plus *resulted* in a tremendous increase in [TNF-alpha] and IL-6 production in cells representing early stage ( Binet A ) disease . Negative_regulation TNF IL20 12535207 1049464 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL20 12535207 1049491 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL20 8957229 401600 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL21 12535207 1049465 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL21 12535207 1049492 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL21 24574581 2886281 The results showed that significantly *inhibited* LPS induced mRNA expression of IL-1ß , [TNF-a] , and IL-6 in macrophages , but not of IFN-? , IL-10 , CCL5 , or CXCL2 . Negative_regulation TNF IL21 24574581 2886284 ELISA analysis showed that also *suppressed* LPS induced production of [TNF-a] and IL-6 in culture supernatants . Negative_regulation TNF IL21 8957229 401601 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL22 12535207 1049448 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL22 12535207 1049475 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL22 19536150 2142407 IL-4 and significantly *reduced* HO-1 mRNA and protein expression , whereas IL-1beta , IL-17A , and [tumor necrosis factor-alpha (TNF-alpha)] increased it . Negative_regulation TNF IL22 8957229 401584 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL24 12535207 1049446 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL24 12535207 1049473 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL24 8957229 401582 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL25 12535207 1049447 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL25 12535207 1049474 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL25 8957229 401583 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL26 12535207 1049452 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL26 12535207 1049479 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL26 8957229 401588 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL27 12535207 1049453 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL27 12535207 1049480 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL27 8957229 401589 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL2RA 16387162 1494286 Compared to CsA therapy , increased TRL concentrations did not further inhibit PCNA expression , *inhibited* expression less on days 1 and 2 and equally high on day 3 , but inhibited expression of IL-2 and [TNF-alpha] significantly higher on days 2 and 3 ( P < .05 ) . Negative_regulation TNF IL2RG 9558115 500060 Studies with Abs to gammac and an IL-4 mutant that is unable to bind to gammac showed that IL-4 can suppress IL-1beta but not [TNF-alpha] production by LPS stimulated monocytes in the *presence* of little or no functioning . Negative_regulation TNF IL3 12535207 1049466 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL3 12535207 1049493 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL3 8748255 344114 IL-4 , IL-10 , and *suppress* gene expression and synthesis of IL-1 and [TNF] . Negative_regulation TNF IL3 8957229 401602 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL3 9126704 426575 These results demonstrate that PGE2 does not affect LT-beta , IL-4 , or in Th2 cells , but *inhibits* [TNF] mRNA accumulation and production in this T cell subset . Negative_regulation TNF IL31 12535207 1049454 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL31 12535207 1049481 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL31 8957229 401590 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL32 12535207 1049451 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL32 12535207 1049478 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL32 21423208 2458142 In addition , when IL-32? was knocked down by small interfering RNA ( siRNA ) or neutralized with an anti-IL-32? antibody , IL-32? induced colon cancer cell growth inhibition , the *induced* decrease of [TNF-a] , IL-1 and IL-6 production , and the increase of IL-10 production were abolished . Negative_regulation TNF IL32 23831355 2824866 *inhibited* LPS induced upregulation of inducible NO synthase (iNOS) , cyclooxygenase-2 , interleukin-6 , [tumor necrosis factor-a] , and interleukin-1ß in RAW264.7 cells in a time- and concentration dependent manner . Negative_regulation TNF IL32 8957229 401587 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL33 12535207 1049450 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL33 12535207 1049477 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL33 23630360 2784446 However , *inhibited* [TNF-a] expression in hepatic T cells and macrophages , and significantly reduced TNF-a levels in the liver . Negative_regulation TNF IL33 8957229 401586 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL34 12535207 1049455 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL34 12535207 1049482 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL34 8957229 401591 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL37 12535207 1049449 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL37 12535207 1049476 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL37 24629023 2925555 In vitro , *inhibited* the production of [TNF-a] , IL-1ß and IL-6 in PBMCs of patients with SLE , whereas the production of IL-10 was unaffected . Negative_regulation TNF IL37 8957229 401585 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL4 10227996 610524 *inhibits* the production of [TNF-alpha] and IL-12 by STAT6 dependent and -independent mechanisms . Negative_regulation TNF IL4 10227996 610530 However , still *induced* significant inhibition of the production of [TNF-alpha] and IL-12 from STAT6 null macrophages that were stimulated with the more physiologically relevant combination of LPS and IFN-gamma . Negative_regulation TNF IL4 10227996 610537 These data show that STAT6 is required for the *mediated* inhibition of the production of [TNF-alpha] and IL-12 stimulated by LPS alone , but that IL-4 also activates distinct , STAT6 independent mechanism(s) that inhibit the IFN-gamma mediated enhancement of IL-12 and TNF-alpha production . Negative_regulation TNF IL4 10233738 611569 Similarly , can not *suppress* LPS induced [tumour necrosis factor-alpha (TNF-alpha)] production by synovial fluid cells and monocyte derived macrophages . Negative_regulation TNF IL4 10433506 634021 IL-2 and counteract budesonide *inhibition* of GM-CSF and IL-10 , but not of IL-8 , IL-12 or [TNF-alpha] production by human mononuclear blood cells . Negative_regulation TNF IL4 10569696 568022 Both and IL-13 significantly *inhibited* [TNF] induced IL-6 release ( P < 0.01 for both ) while augmenting the effect of IFNgamma ( P < 0.005 and P < 0.01 , respectively. ) . Negative_regulation TNF IL4 10632444 576569 *inhibited* the expression of granulocyte-macrophage colony stimulating factor , interleukin-6 , and [tumor necrosis factor-alpha] at 48 hours in a dose dependent manner . Negative_regulation TNF IL4 10719355 676934 IL-10 ( 10 and 100 ng/ml ) and ( 5 and 50 U/ml ) *suppressed* the LPS induced production of NO , IL-6 , and [TNF-alpha] in a dose dependent manner , whereas TGF-beta1/beta2 ( 2 and 20 ng/ml ) only suppressed NO production . Negative_regulation TNF IL4 10795524 689672 *reduced* virus induced [TNF-alpha] secretion and nuclear factor (NF)-kappaB activation significantly , but less in cells concomitantly treated with IFN-gamma . Negative_regulation TNF IL4 10929063 719674 This progressive phase is accompanied by increasing expression of , and *diminished* expression of IL-1 and [TNF-alpha] . Negative_regulation TNF IL4 10954049 724510 Production of [tumor necrosis factor (TNF)-alpha] and IL-1beta by mouse mesangial cells was not blocked by SSA but production of by these cells was *inhibited* by it ( > 0.1 mM ) . Negative_regulation TNF IL4 11505428 847921 Enzyme linked immunosorbent assay and reverse transcription-polymerase chain reaction showed that both and IL-10 significantly *reduced* the production of [TNF-alpha] and IL-6 . Negative_regulation TNF IL4 11719504 904137 also selectively *inhibits* [TNF] signaling , while enhancing that of IL-1 . Negative_regulation TNF IL4 11908571 923613 The antiinflammatory cytokine *blocked* LTB4 dependent stimulation of IL-1beta and [TNF-alpha] synthesis . Negative_regulation TNF IL4 11919547 926047 We found that [TNF-alpha] *induces* apoptosis in a time- and dose dependent manner , whereas inhibits TNF-alpha induced and spontaneous apoptosis of biomaterial-adherent macrophages . Negative_regulation TNF IL4 11991671 938498 While IL-4 can suppress LPS induced interleukin beta (IL-beta) and tumour necrosis factor alpha (TNF-alpha) production by monocytes , can *suppress* LPS induced IL-1 beta , but not [TNFalpha] production by the more differentiated cells . Negative_regulation TNF IL4 11991671 938527 Like MDMac , interferon alpha (IFNalpha) treated monocytes expressed less IL-4 receptor gamma c chain , reduced levels of IL-4 activated STAT6 and could not *suppress* LPS induced [TNFalpha] production . Negative_regulation TNF IL4 12111847 963559 The LPS induced secretion of IL-1beta and TNF-alpha was only reduced after application of ACM , whereas or IL-10 did not *inhibit* IL-1beta- or [TNF-alpha] secretion . Negative_regulation TNF IL4 12193748 981557 HAT partially inhibited production of [TNF-alpha] and completely *inhibited* production of , IL-5 , and IL-10 . Negative_regulation TNF IL4 12535207 1049467 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL4 12535207 1049494 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL4 12569762 581592 *suppressed* the expression of both [TNF-alpha] and IL-1 alpha mRNA by PBMCs from SFH patients before and after treatment dose-dependently . Negative_regulation TNF IL4 12569762 581593 When PBMCs were cultured in the presence of IL-4 at a concentration of 100 U/ml , *down-regulated* the production of both [TNF-alpha] and IL-1 alpha mRNA by acute phase PBMCs only to 18.18-21.98 % of control cells ( in absence of IL-4 ) , while the inhibitory rates were all near to 50 % in recovery phases . Negative_regulation TNF IL4 12670721 1076155 Both and IL-13 *inhibit* the [TNF-alpha] and IFN-gamma enhanced MDC production in a human keratinocyte cell line , HaCaT cells . Negative_regulation TNF IL4 12670721 1076161 Both and IL-13 *inhibited* [TNF-alpha] and IFN-gamma enhanced MDC production in HaCaT cells in a dose dependent manner . Negative_regulation TNF IL4 12860673 1111558 Although *inhibited* C. burnetii stimulated release of [TNF] , the addition of recombinant TNF to IL-4 treated monocytes did not prevent the IL-4 effect . Negative_regulation TNF IL4 12925206 1131246 Among T helper 1 cytokines , *mediated* suppression of [tumor necrosis factor-alpha] was not affected by terfenadine , which , however , markedly restored mRNA expression of interferon-gamma or interleukin-2 . Negative_regulation TNF IL4 12960356 1138458 We found that IL-13 and *inhibited* [TNF-alpha-] and IFN-gamma induced HBD-3 production . Negative_regulation TNF IL4 1306226 209015 *inhibited* the production of IL-1 and [TNF-alpha] by AM at the protein and mRNA levels . Negative_regulation TNF IL4 1309848 178456 *inhibits* human macrophage activation by [tumor necrosis factor] , granulocyte-monocyte colony stimulating factor , and interleukin-3 for antileishmanial activity and oxidative burst capacity . Negative_regulation TNF IL4 1328039 197733 *reduced* [TNF-alpha] production by monocytes when IL-4 and lipopolysaccharide (LPS) were added concomitantly , or upon subsequent activation by LPS 16 hr after first exposure to IL-4 . Negative_regulation TNF IL4 14631390 1170546 These data provide evidence that BALB/c mice can respond to exogenous IL-12 , that the cytokine promotes susceptibility by *increasing* IFN-gamma and [TNF-alpha] production , with a concomitant reduction in levels ; Negative_regulation TNF IL4 14638848 1176704 In this paper , we investigated the regulatory *role* of in [TNF-alpha] production in mast cells . Negative_regulation TNF IL4 14638848 1176707 *inhibited* immunoglobulin E-induced [TNF-alpha] production and neutrophil recruitment in the peritoneal cavity in wild-type mice but not in signal transducers and activators of transcription 6 ( Stat6 ) -deficient mice . Negative_regulation TNF IL4 14638848 1176708 also *inhibited* [TNF-alpha] production in cultured mast cells by a Stat6 dependent mechanism . Negative_regulation TNF IL4 14638848 1176711 Furthermore , IL-4 induced the expression of tristetraprolin (TTP) , an RNA binding protein that promotes decay of ARE containing mRNA , in mast cells by a Stat6 dependent mechanism , and the depletion of TTP expression by RNA interference prevented *induced* down-regulation of [TNF-alpha] production in mast cells . Negative_regulation TNF IL4 15290727 1278558 In vitro [tumor necrosis factor-alpha (TNF-alpha)] , interferon-gamma (IFN-gamma) , and interleukin 6 (IL-6) responses were *detected* during reactions to most antigens tested , while responses were absent . Negative_regulation TNF IL4 1551940 184082 *inhibited* the production of IL-6 , IL-1 beta , and [tumor necrosis factor alpha (TNF alpha)] by both controls and rheumatoid patients . Negative_regulation TNF IL4 1559582 184605 also *suppressed* the production of IL-1 and [TNF alpha] by monocyte derived macrophages . Negative_regulation TNF IL4 1571090 187167 The suppressive effects of IL-4 appear to be dependent upon de novo protein synthesis , as cycloheximide abrogated the *induced* reduction in [TNF-alpha] mRNA levels from PBM . Negative_regulation TNF IL4 16078585 1442529 The results indicated that thalidomide treatment significantly reduced colonic inflammation , suppressed NF-kappaB activation , enhanced TNF-alpha mRNA degradation , *inhibited* the synthesis of the [TNF-alpha] , IEN-gamma and increased the production of . Negative_regulation TNF IL4 1627494 191738 Both and IL-10 [ cytokine synthesis inhibitory factor ( CSIF ) ] *inhibit* IL-2 induced synthesis of IFN-gamma and [tumor necrosis factor (TNF)-alpha] by human PBMC . Negative_regulation TNF IL4 16427155 1547551 The results show that p17 , while ineffective on resting monocytes , exerts an inflammatory action on *mediated* inhibition of [TNF-alpha] and IFN-gamma production induced by IL-15 stimulation . Negative_regulation TNF IL4 1696166 137210 Interestingly , in combination with IL-2 *inhibited* the IL-2-driven induction of [TNF] and LT mRNA . Negative_regulation TNF IL4 17045026 1635688 IL-7 and IL-15 could affect the balance between Th1 and Th2 cytokines by inducing IFN-gamma and [TNF-alpha] production and *inhibiting* and IL-10 expression . Negative_regulation TNF IL4 18178046 1869960 Different dilutions of Sayali olive oil dose-dependently inhibited the production of [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-4 (IL-4) , and different dilutions of Zarrazi olive oil dose-dependently *inhibited* histamine release and production by calcium ionophore A23187 plus phorbol 12-myristate 13-acetate ( PMA ) -stimulated KU812 cells . Negative_regulation TNF IL4 1901829 155915 [TNF] levels induced by IL-2 were similarly *reduced* by both in normal donors ( P less than 0.003 ) and in patients ( P less than 0.01 ) . Negative_regulation TNF IL4 19536150 2142408 and IL-22 significantly *reduced* HO-1 mRNA and protein expression , whereas IL-1beta , IL-17A , and [tumor necrosis factor-alpha (TNF-alpha)] increased it . Negative_regulation TNF IL4 19688741 2175822 Furthermore , the production of was severely impaired , and GM-CSF , [TNF-alpha] and IL-13 levels were also *diminished* . Negative_regulation TNF IL4 20406299 2300596 *suppressed* LPS induced [TNF-alpha] in freshly isolated monocytes at the level of transcription but acted by a different , possibly translational , mechanism in monocytes cultured overnight in macrophage colony stimulating factor ( M-CSF ) . Negative_regulation TNF IL4 2110990 132883 can also *suppress* the increased release of IL-1 beta and [TNF alpha] by monocytes incubated with indomethacin , a non-steroidal anti-inflammatory drug . Negative_regulation TNF IL4 2113430 135572 In addition to suppression of LAK induction , also *inhibits* IL-2 induced IFN-gamma and [TNF-alpha] protein production in PBMC . Negative_regulation TNF IL4 2119829 141849 was found to *inhibit* the secretion of IL-1 beta and [TNF alpha] by activated monocytes almost 100 % . Negative_regulation TNF IL4 2123823 145342 This suggests that [tumor necrosis factor] , in addition to gamma interferon , may be involved in resistance to L. major and that may *inhibit* the leishmanicidal activity of tumor necrosis factor and/or gamma interferon . Negative_regulation TNF IL4 21468627 2554253 Exogenous also *attenuated* [TNF-a] , IL-1ß , iNOS , and COX-2 expressions in ifosfamide treated bladders . Negative_regulation TNF IL4 23028901 2680705 It was found that interferon ( IFN ) -? was produced only by decidual immune cells ( DICs ) , and not by trophoblasts or decidual stromal cells ( DSCs ) ; all these cells secreted , IL-10 , and tumor necrosis factor (TNF)-a. Treatment with CsA completely blocked IFN-? production in DICs and *inhibited* [TNF-a] production in all examined cells . Negative_regulation TNF IL4 2334896 132663 In contrast to IL-2 , recombinant murine *down-regulated* [TNF] synthesis by macrophages . Negative_regulation TNF IL4 23351078 2769919 and IL-13 *inhibit* IL-1ß and [TNF-a] induced kinin B1 and B2 receptors through a STAT6 dependent mechanism . Negative_regulation TNF IL4 2668014 116181 *inhibited* the production and the release of [tumor necrosis factor] alpha activity by monocytes stimulated with LPS . Negative_regulation TNF IL4 7508593 240148 TGF beta , , and IL-10 *inhibit* production of IL-1 and [TNF] . Negative_regulation TNF IL4 7547698 327062 When the cells were cultured with TNF-alpha for more than 24 h , however , [TNF-alpha] down-regulated *induced* Fc epsilon RII mRNA levels . Negative_regulation TNF IL4 7594490 334769 The sCD23 induced [TNF-alpha] production is significantly *inhibited* by and IL-10 but not by TGF-beta . Negative_regulation TNF IL4 7852846 294753 , IL-10 , and IL-13 *suppressed* the generation of antitumor activity and cytokine production ( IL-1 beta and [TNF-alpha] ) of monocytes stimulated with MCAF plus norMDP or LPS . Negative_regulation TNF IL4 7930948 275144 , when added together with bacterial lipopolysaccharide (LPS) , *suppressed* LPS induced increases in mRNA levels of IL-1 alpha , IL-1 beta , IL-8 , and [TNF-alpha] in alveolar macrophages . Negative_regulation TNF IL4 8038234 265368 , a product of the T-helper 0 ( Th0 ) and 2 ( Th2 ) subset , was originally described as a B-cell stimulatory factor and has subsequently been found to *suppress* IL-1 alpha , IL-1 beta , IL-6 , IL-8 , and [TNF-alpha] gene expression in monocytes stimulated with LPS , and to upregulate IL-1 receptor antagonist (IL1-RA) gene expression . Negative_regulation TNF IL4 8038234 265372 *down-regulated* mRNA accumulation of the proinflammatory cytokines IL-1 beta , IL-8 , and [TNF-alpha] in monocytes stimulated with IL-2 , IL-3 , and GM-CSF . Negative_regulation TNF IL4 8136803 242155 Since *inhibits* the production of proinflammatory cytokines such as IL1 , IL6 , [TNF alpha] and IL8 , we hypothesized that a deficit in IL4 production might be related to the pathogenesis of rheumatoid arthritis . Negative_regulation TNF IL4 8218932 231783 *inhibited* the increase in p55 and p75 [TNF-R] on PBMC following adherence , whereas IL-4 upregulated p75 TNF-R expressed on PHA induced T cell blasts . Negative_regulation TNF IL4 8289467 247699 ( whether added at T0 or T48h ) also *inhibited* spontaneous release of TNF and IL-6 measured at 48 and 120 h . [TNF] and IL-4 had no consistent effect on normal cord blood CD5+ B-cells . Negative_regulation TNF IL4 8289467 247700 These data show that has inhibitory effects on B-CLL DNA synthesis and also *inhibits* spontaneous release of IL-6 and [TNF] in vitro . Negative_regulation TNF IL4 8381194 210362 did not have any major effects on the production of TNF-alpha in activated cells , but *inhibited* the IL-2 induced production of [TNF-alpha] in SAC activated cells . Negative_regulation TNF IL4 8426089 211062 *suppressed* both [m-TNF] production and TNF-alpha secretion . Negative_regulation TNF IL4 8429684 212728 *down-regulated* [TNF-alpha] production by monocytes , but in contrast interferon-gamma (IFN-gamma) moderately enhanced TNF-alpha production . Negative_regulation TNF IL4 8574153 342204 PAI was able to *induce* the production of IFN-gamma and [TNF-alpha] while that of and IL-1 beta was reduced . Negative_regulation TNF IL4 8704096 371118 *reduced* [TNF-alpha] release , in a dose dependent manner , to 62 % and IL-1 alpha release to 42 % of LPS stimulated AM without IL-4 . Negative_regulation TNF IL4 8742066 377133 LPS stimulated release of [TNF-alpha] declined substantially after the first day and was consistently *suppressed* by IL-10 and but increased by IFN-gamma . Negative_regulation TNF IL4 8871669 389622 The predominant [TNF] receptor on monocytes , the p75 receptor , was *down-regulated* by at the mRNA level . Negative_regulation TNF IL4 8957229 401603 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL4 9126704 426576 These results demonstrate that PGE2 does not affect LT-beta , , or IL-3 in Th2 cells , but *inhibits* [TNF] mRNA accumulation and production in this T cell subset . Negative_regulation TNF IL4 9162077 431914 The production of [tumor necrosis factor-alpha (TNF-alpha)] by lipopolysaccharide (LPS) stimulated macrophages can be markedly *inhibited* by the two closely related cytokines , and IL-13 . Negative_regulation TNF IL4 9233653 445123 Further , while serum TNF-alpha levels induced by Con A were greatly decreased in NK1+ T cell depleted mice and class I-deficient mice , [TNF-alpha] levels were *recovered* by exogenous . Negative_regulation TNF IL4 9558115 500061 Studies with Abs to gammac and an IL-4 mutant that is unable to bind to gammac showed that can *suppress* IL-1beta but not [TNF-alpha] production by LPS stimulated monocytes in the presence of little or no functioning gammac . Negative_regulation TNF IL4 9558115 500065 also *suppressed* IL-1beta but not [TNF-alpha] production by Mono Mac 6 cells , which express minimal levels of gammac . Negative_regulation TNF IL5 12193748 981558 HAT partially inhibited production of [TNF-alpha] and completely *inhibited* production of IL-4 , , and IL-10 . Negative_regulation TNF IL5 12535207 1049468 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL5 12535207 1049495 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL5 23690470 2796739 Monocyte derived *reduces* [TNF] production by Mycobacterium tuberculosis-specific CD4 T cells during SIV/M. tuberculosis coinfection . Negative_regulation TNF IL5 8957229 401604 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL6 10201958 605713 We have observed that NGF at doses as low as 10 ng/ml will induce production and *inhibit* [TNF-alpha] release from rat peritoneal mast cells in the presence of lysophosphatidylserine as a cofactor . Negative_regulation TNF IL6 10319886 612051 Conversely , treatment of PBMCs with the adenosine A1 receptor agonist R-phenylisopropyladenosine (R-PIA) ( 1 microM ) significantly inhibited mitogen stimulated production of [TNF alpha] but not IL-6 in control subjects and significantly *inhibited* production of but not TNF alpha in MS patients . Negative_regulation TNF IL6 10653854 663329 In addition , the complex *reduced* the TNF-alpha induced proliferation of synovial cells while [TNF-alpha] induced their IL-6 production . Negative_regulation TNF IL6 11061591 479696 We also showed that regardless of the presence or absence of CSF-1 or FN , *inhibits* GM-CSF and [TNF-alpha] gene expression in an autocrine manner . Negative_regulation TNF IL6 11134960 769692 [TNF-alpha] gene expression was also dramatically reduced by SNP , but gene expression was *inhibited* much less . Negative_regulation TNF IL6 11446746 835431 We recently found that CGRP induces IL-6 and [TNF-alpha] in long-term bone marrow cultures and that and TNF-alpha also *inhibit* IL-7 responses . Negative_regulation TNF IL6 11964604 932792 After HX-XO administration , [TNF-alpha] was reliably detected at 60 min and at 90 min. Simultaneous infusion of isoproterenol *inhibited* TNF-alpha and interleukin-6 release . Negative_regulation TNF IL6 11991629 938487 We found that butyrate at the six tested concentrations *induced* a significant decrease ( P < 0.001 ) in the stimulated release of [TNF-alpha] , IFN-gamma , and IL-12 , whereas release was not altered . Negative_regulation TNF IL6 12023001 943480 During the 24-hour postoperative period , GGA significantly suppressed the release of aspartate or alanine aminotransferase and elevation of the serum level , and completely *inhibited* an increase in the serum level of [tumor necrosis factor-alpha] . Negative_regulation TNF IL6 12535207 1049469 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL6 12535207 1049496 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL6 12690457 1080262 In addition , *inhibits* low-level [TNF-alpha] production , and IL-6 produced during exercise probably inhibits TNF-alpha induced insulin resistance in peripheral tissues . Negative_regulation TNF IL6 12754507 1093561 In macrophages lacking the Socs3 gene or carrying a mutation of the SOCS3 binding site in gp130 , the lipopolysaccharide induced production of [tumor necrosis factor (TNF)] and IL-12 is *suppressed* by both IL-10 and . Negative_regulation TNF IL6 12869027 1112129 IgG prevented [TNFalpha] induced CD106 membrane expression and an increase in [ Ca++]i , and *inhibited* the secretion of and macrophage-colony stimulating factor ( M-CSF ) . Negative_regulation TNF IL6 1404130 199613 In contrast , flurbiprofen completely abolished production by both cell lines and substantially *inhibited* IL-1 beta and [TNF alpha] production . Negative_regulation TNF IL6 15247147 1289574 Moreover , *inhibited* production of [tumor necrosis factor-alpha (TNF-alpha)] and interferon-gamma inducible protein-10 ( IP-10 ) in DC , and DC-driven allogeneic T cell proliferation in mixed lymphocyte reactions . Negative_regulation TNF IL6 15265664 1275319 UCB leads to an increase of extracellular glutamate and highly *enhances* the release of [TNF-alpha] and IL-1beta , while inhibiting the production of . Negative_regulation TNF IL6 15772055 1384483 stimulates the appearance in the circulation of other anti-inflammatory cytokines such as IL-1ra and IL-10 and *inhibits* the production of the proinflammatory cytokine [TNF-alpha] . Negative_regulation TNF IL6 15893771 1419776 At 200 ng/ml [TNFalpha] , SOCS3 mRNA levels were increased , but significantly *reduced* in the presence of IL-1beta or ( P < 0.05 ) . Negative_regulation TNF IL6 15919375 1353162 While production of and KC was reduced , secretion of [TNF-alpha] and MIP-1alpha was *enhanced* in those cells isolated from mice with mild sepsis . Negative_regulation TNF IL6 16464741 1495668 Multiple immune mediators have been mentioned as playing a role in the pathomechanism of type1 DM. Interleukin (IL)-1beta , and tumor necrosis factor (TNF)-alpha play a central role in the autoimmune destruction of pancreatic beta-cells , whereas *inhibits* [TNF-alpha] secretion , and may have some protecting effects . Negative_regulation TNF IL6 1730779 181317 [Tumor necrosis factor] stimulates DNA synthesis of mouse hepatocytes in primary culture and is *suppressed* by transforming growth factor beta and . Negative_regulation TNF IL6 18349186 1887037 The mu opioid receptor mediates morphine induced [tumor necrosis factor] and *inhibition* in toll-like receptor 2-stimulated monocytes . Negative_regulation TNF IL6 18389438 1893232 Lycopene *induced* a dose dependent increase in IL1beta , and [TNFalpha] production and a decrease in IL-2 , IL-10 and IFNgamma secretion , whereas that of and IL-1ra was not affected . Negative_regulation TNF IL6 18480275 1910665 Consistently , [TNFalpha] and IL-1beta enhanced AMPA- or NMDA induced currents , and IL-1beta and *suppressed* GABA- and glycine induced currents . Negative_regulation TNF IL6 19389588 2070001 This article presents several compelling potential mechanisms for the anti-inflammatory effect of exercise , including reduced percentage of body fat and macrophage accumulation in adipose tissue , muscle released *inhibition* of [tumor necrosis factor-a] , and the cholinergic anti-inflammatory pathway . Negative_regulation TNF IL6 19528220 2121054 If pneumococcal LytA was inactivated by mutation or by culture in a medium containing excess choline , the pneumococci *induced* production of significantly more [TNF] , IFN-gamma , and IL-12 in PBMC , whereas the production of , IL-8 , and IL-10 was unaffected . Negative_regulation TNF IL6 19528220 2121066 Further , adding autolyzed pneumococci to intact bacteria inhibited production of [TNF] , IFN-gamma , and IL-12 in a dose dependent manner but did not *inhibit* production of , IL-8 , and IL-10 in response to the intact bacteria . Negative_regulation TNF IL6 19774506 2202817 These results suggest that the anti-inflammatory properties of madecassic acid are caused by iNOS , COX-2 , [TNF-alpha] , IL-1beta , and *inhibition* via the downregulation of NF-kappaB activation in RAW 264.7 macrophage cells . Negative_regulation TNF IL6 2005401 154741 in turn *inhibited* [TNF] and IL-1 expression , suggesting that IL-6 may be part of a negative feedback mechanism in the cytokine cascade . Negative_regulation TNF IL6 20128155 2178929 The expression of TLR4 , TNF-alpha and in the myocardium significantly *increased* in the MI group and simvastatin markedly inhibits the expression of TLR4 , [TNF-alpha] , and IL-6 in the myocardium after MI. Serum TNF-alpha and IL-6 levels between the MI group and the simvastatin group remained unchanged . Negative_regulation TNF IL6 20654553 655791 Chromium extract did not impair [TNFalpha] release significantly , but *inhibited* release significantly in stimulated PBMC . Negative_regulation TNF IL6 2105994 127031 Although IFN-gamma , , granulocyte CSF , and granulocyte-macrophage CSF induced nitroblue tetrazolium reducing activity of U-937 cells , only IFN-gamma , and [TNF] *induced* it synergistically in combination with TGF-beta 1 . Negative_regulation TNF IL6 21153080 407636 Serotonin ( 1-1000 nM ) increased basal release from zona glomerulosa cells , but *inhibited* basal [TNF] release from these cells . Negative_regulation TNF IL6 21153080 407638 Serotonin potentiated release stimulated by endotoxin and IL-1ß , but *inhibited* [TNF] release stimulated by these agents . Negative_regulation TNF IL6 21551509 2444986 1733 immunoglobulin receptors ( IgR ) of single cell sorted preswitch and postswitch memory B cells were prospectively analysed from 11 RA patients under inhibition ( 7 patients ) or [tumour necrosis factor (TNF)] *inhibition* ( 4 patients ) . Negative_regulation TNF IL6 21849156 2495956 Similarly , LPS induced increases in [TNF-a] , IL-1ß and protein levels in NR8383 cell supernatants was significantly *inhibited* by MD-2 silencing . Negative_regulation TNF IL6 21910594 2567681 IND and EP4A inhibited the upregulation of [TNF-a] mRNA expression , and only EP4A *inhibited* and RANKL mRNA expressions in ST2 cells with LPS stimulation . Negative_regulation TNF IL6 21948282 2599297 10H2DA inhibited LPS induced production dose-dependently , but did not *inhibit* [TNF-a] production . Negative_regulation TNF IL6 21952924 2539330 MI192 inhibited [TNF] production at high concentrations and dose-dependently *inhibited* in RA PBMCs but not healthy PBMCs , across a dose range of 10 µM-5 nM . Negative_regulation TNF IL6 2294996 127511 did not stimulate IL-1 beta or TNF production , but *suppressed* IL-1 beta and [TNF] production induced by LPS or PHA by 30 % ( P less than .01 ) . Negative_regulation TNF IL6 22953812 2667614 Fucosterol suppressed the expressions of inducible nitric oxide synthase (iNOS) , [tumour necrosis factor-a (TNF-a)] , and interleukin-6 (IL-6) by downregulating their transcriptions , and subsequently *inhibited* the productions of nitric oxide , TNF-a , and . Negative_regulation TNF IL6 23183089 2736218 The results also found that there was significant reduction levels of IL-6 , IL-8 and [TNF-a] in serum of CIA rats treated with ATW and ATW *inhibited* the expression of , IL-8 , NF-?B , TNF-a in synovial tissue . Negative_regulation TNF IL6 23708661 2926299 Induction of LPLUNC1 overexpression in NPC cells mitigated lipopolysaccharide (LPS) induced IL-6 , IL-8 , [tumor necrosis factor-a] and IL-1ß expression or treatment of THP-1 macrophages with LPLUNC1 *inhibited* spontaneous and LPS induced expression in vitro . Negative_regulation TNF IL6 23774598 2824013 was significantly inhibited in all organs , IL-1ß and IP-10 were significantly inhibited in liver , spleen , and kidneys , and [tumor necrosis factor] , IL-8 , and PAI-1 were *inhibited* only in the spleen . Negative_regulation TNF IL6 23799152 2802840 Knocking down WWP1 enhanced the [TNF-a] and IL-6 production induced by LPS , and over-expression of WWP1 *inhibited* the TNF-a and production induced by LPS , but not by TNF-a . Negative_regulation TNF IL6 23853585 2816994 Instead , SOCS3 expression in infected macrophages and DCs prevented the *mediated* inhibition of [TNF] and IL-12 secretion and contributed to a timely CD4+ cell dependent IFN-? expression in vivo . Negative_regulation TNF IL6 23928112 2850064 Diaphragm and hindlimb muscles showed a rapid rise in and interleuin-10 (IL-10) mRNA and transient *inhibition* of [tumor necrosis factor-a (TNF-a)] and interleukin-1ß (IL-1ß) throughout early recovery , a pattern that parallels changes in circulating cytokines . Negative_regulation TNF IL6 24771848 2937056 Similar effects are evident also on other cytokines : [TNF-a] is *induced* , whereas is inhibited by costimulation . Negative_regulation TNF IL6 2584704 122231 *inhibits* lipopolysaccharide induced [tumor necrosis factor] production in cultured human monocytes , U937 cells , and in mice . Negative_regulation TNF IL6 7572286 328890 In this study , we demonstrate that transforming growth factor-beta ( TGF-beta ) , interleukin-10 (IL-10) and *inhibit* [tumor necrosis factor-alpha] expression by primary rat astrocytes . Negative_regulation TNF IL6 7600192 311506 LPS1 significantly increased LPS2 triggered monocyte secretion of IL-1 , , and PGE2 , but *inhibited* [TNF] release . Negative_regulation TNF IL6 7875741 287589 However , after chlorination Gram positive bacteria lost their ability to *induce* NO and [TNF-alpha] , whereas phagocytosis and production were not affected by chlorination . Negative_regulation TNF IL6 8157061 253335 However , production of [tumor necrosis factor (TNF)] and interleukin-1 in the pleural exudate was significantly *enhanced* by the pretreatment with indomethacin , whereas the level was reduced . Negative_regulation TNF IL6 8178969 256040 Our results show that expression persisted at incubation temperatures in the upper end of the physiological range that induced heat shock and *attenuated* the expression of functionally active [TNF-alpha] in LPS stimulated HuMoM phi . Negative_regulation TNF IL6 8397259 230466 At doses greater than 0.1 to 100 ng/mL , *inhibited* IFN-gamma and [TNF-alpha] activation by 21 to 93 % and 36 to 82 % , respectively . Negative_regulation TNF IL6 8537402 338615 Transcriptional *roles* of nuclear factor kappa B and nuclear in the [tumor necrosis factor] alpha dependent induction of cyclooxygenase-2 in MC3T3-E1 cells . Negative_regulation TNF IL6 8660820 367098 When human monocytes/macrophages stimulated with silica were treated with 0.1-10 microg/ml acanthoic acid , the production of IL-1 and [TNF-alpha] was inhibited up to 90 % , but the production of was not *inhibited* at all . Negative_regulation TNF IL6 8664982 368687 Dopamine increases release and *inhibits* [tumor necrosis factor] release from rat adrenal zona glomerulosa cells in vitro . Negative_regulation TNF IL6 8724532 376738 ( 100 U/ml or greater ) increased spontaneous DNA synthesis ( 3H-TdR uptake ) but , in the presence of high concentrations of TNF-alpha , *inhibited* [TNF] induced DNA synthesis in a dose dependent manner . Negative_regulation TNF IL6 8732437 374090 Furthermore , the complex significantly *suppressed* IL-1 beta- , [TNF alpha-] and PDGF-AA induced DF proliferation . Negative_regulation TNF IL6 8957229 401605 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL6 9030200 413774 Mimicking this ` defect ' on normal mononuclear cells with ouabain has been shown to *induce* [TNF alpha] and , in particular , IL-l beta production , whereas synthesis was suppressed . Negative_regulation TNF IL6 9126707 426585 Adenosine increased release and *inhibited* [TNF] release from ovarian cells . Negative_regulation TNF IL6 9126707 426587 Thus , in immune and endocrine tissues , adenosine increases release , but *inhibits* [TNF] release . Negative_regulation TNF IL6 9195128 438203 Interestingly , potently *inhibited* LPS induced [TNF] production by macrophagic cells but not by a microglial cell clone , suggesting that the defective response to IL-6 of the brain lies within the responsiveness TNF producing cells to IL-6 . Negative_regulation TNF IL6 9756751 535785 The drug also prevented release in lung homogenates and partly *inhibited* [TNF-alpha] , but it did not interfere with IL-1alpha secretion in the lungs of infected mice . Negative_regulation TNF IL6ST 9485206 488253 We show here that engagement of the CD94-NKG2A *inhibits* both antigen-driven [tumor necrosis factor (TNF)] release and cytotoxicity on melanoma-specific human T cell clones . Negative_regulation TNF IL7 11446746 835432 We recently found that CGRP induces IL-6 and [TNF-alpha] in long-term bone marrow cultures and that IL-6 and TNF-alpha also *inhibit* responses . Negative_regulation TNF IL7 12535207 1049470 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL7 12535207 1049497 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL7 8957229 401606 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL8 11535888 854818 At 40 minutes , and GROalpha significantly *inhibited* [TNFalpha] adherence dependent peroxide production in normal neutrophils ( 35 % +/- 4 % and 45 % +/- 3 % , respectively ; p < 0.05 ) . Negative_regulation TNF IL8 12519385 1047727 At a concentration of 40 mmol/l , the IL-1 beta , IL-6 and [TNF alpha] responses were *reduced* by more than 95 % and the levels reduced by 85 % . Negative_regulation TNF IL8 12535207 1049471 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL8 12535207 1049498 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL8 12599057 1062159 Moreover , H. pylori infection of primary cells *induced* a regulated production of interleukin (IL)-6 , IL-8 , and [tumor necrosis factor-alpha] , whereas infection of cell lines only resulted in production . Negative_regulation TNF IL8 12811578 1113564 Comparative effects of polyphenols from green tea ( EGCG ) and soybean ( genistein ) on VEGF and release from normal human keratinocytes *stimulated* with the proinflammatory cytokine [TNFalpha] . Negative_regulation TNF IL8 16926027 1615018 Addition of exogenous Ub ( equaling day 42 concentration ) to day 0-4 plasma inhibited [TNF-alpha] production by one-third of the effect detected for day 42 plasma , but also *inhibited* production by 40 % . Negative_regulation TNF IL8 17491020 1761562 The alpha , beta unsaturated aldehydes in cigarette smoke ( acrolein and crotonaldehyde ) inhibited production of interleukin-2 (IL-2) , IL-10 , granulocyte-macrophage colony stimulating factor , interferon-gamma , and [tumor necrosis factor-alpha] by human T cells but did not *inhibit* production of . Negative_regulation TNF IL8 18461339 1979040 Furthermore , cells treated with avenanthramides showed a significant inhibition of [tumor necrosis factor-alpha (TNF-alpha)] *induced* NF-kappaB luciferase activity and subsequent reduction of release . Negative_regulation TNF IL8 18528959 1934274 High levels remained consistent during the followup , but [TNF-alpha] was already *reduced* after 10 days and until 6 months after therapy . Negative_regulation TNF IL8 19046141 1999003 P4 enhanced the production of IL-1beta and , but *inhibited* [TNF-alpha] production by monocytes stimulated with either organism . Negative_regulation TNF IL8 19528220 2121055 If pneumococcal LytA was inactivated by mutation or by culture in a medium containing excess choline , the pneumococci *induced* production of significantly more [TNF] , IFN-gamma , and IL-12 in PBMC , whereas the production of IL-6 , , and IL-10 was unaffected . Negative_regulation TNF IL8 19528220 2121067 Further , adding autolyzed pneumococci to intact bacteria inhibited production of [TNF] , IFN-gamma , and IL-12 in a dose dependent manner but did not *inhibit* production of IL-6 , , and IL-10 in response to the intact bacteria . Negative_regulation TNF IL8 20067543 2177774 Here we demonstrate that tumour derived prostaglandin E2 ( PGE ( 2 ) ) and transforming growth factor-beta ( TGF-beta ) increase but synergistically *inhibit* interferon-alpha (IFN-alpha) and [tumour necrosis factor (TNF)] production of Toll-like receptor 7 (TLR7)- and Toll-like receptor 9 (TLR9) stimulated PDC . Negative_regulation TNF IL8 23918984 2830792 WSN virus infection induced expression of [TNF-a] , IFN-ß , and is *inhibited* by EZH2 and its catalytic dead form ?SET . Negative_regulation TNF IL8 8172855 255425 In contrast , oxLDL did not alter LPS mediated production of and actually *inhibited* LPS induced secretion of [tumor necrosis factor-alpha] , suggesting that some aspects of the signaling pathways for TF induction differ from those of other LPS-responsive monocyte/macrophage gene products . Negative_regulation TNF IL8 8188354 256762 IL-1 alpha and [TNF-alpha] *induced* significantly higher levels of secretion than did E. coli Hu734 . Negative_regulation TNF IL8 8957229 401607 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF IL8 8973628 403050 During normoxia , LPS was the most potent stimulus , inducing the release of each cytokine , while fMLP showed a less pronounced effect on and IL-1 beta production and markedly *inhibited* [TNF-alpha] production . Negative_regulation TNF IL9 11937570 928250 *inhibits* oxidative burst and [TNF-alpha] release in lipopolysaccharide stimulated human monocytes through TGF-beta . Negative_regulation TNF IL9 11937570 928251 also *down-regulated* [TNF-alpha] and IL-10 release by LPS stimulated monocytes . Negative_regulation TNF IL9 12535207 1049472 Remarkably , the exogenous totally *blocked* ultraviolet-B induced [tumor necrosis factor] alpha production . Negative_regulation TNF IL9 12535207 1049499 Thus , strongly *inhibits* [tumor necrosis factor] alpha production by noninflammatory skin cells , mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter . Negative_regulation TNF IL9 8957229 401608 Plasma and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) *inhibited* the increased plasma interleukin-1 ( 100.0 % ) and plasma [TNF-alpha] ( 89.2 % ) levels . Negative_regulation TNF INA 21795525 2495173 [TNF-a] *induced* a reversible dose- and time dependent inhibition of . Negative_regulation TNF INHBA 10692249 670730 However , [TNF-alpha] production was significantly *inhibited* by 50 ng/ml in both choriodecidual and placental explants ( to 43+/-9.7 per cent and 51+/-6.7 per cent of control , respectively ) . Negative_regulation TNF INPP5D 15701712 1409572 SHIP1-specific RNA interfering and SHIP1 overexpression experiments demonstrate that *inhibits* LPS induced [tumor necrosis factor alpha (TNF-alpha)] and interleukin 6 (IL-6) production by negatively regulating the LPS induced combination between TLR4 and myeloid differentiation factor 88 ( MyD88 ) ; Negative_regulation TNF INS 11545628 855520 *inhibits* [TNF alpha] and enhances TGF beta production , augments nitric oxide synthesis and blocks superoxide anion generation . Negative_regulation TNF INS 12765944 1094129 Globular adiponectin further enhanced *stimulated* glucose uptake at submaximal insulin concentrations and reversed the inhibitory effect of [tumor necrosis factor-alpha] on insulin stimulated glucose uptake . Negative_regulation TNF INS 14532168 1185896 In conclusion , the finding that stimulates IL-6 and TNF-alpha gene expression in adipose tissue only and *inhibits* the [TNF-alpha] production in skeletal muscles suggests a differential regulation of muscle- and adipose tissue derived IL-6 and TNF-alpha . Negative_regulation TNF INS 17373630 1713842 Role of tumor suppressor PTEN in [tumor necrosis factor] alpha *induced* inhibition of signaling in murine skeletal muscle C2C12 cells . Negative_regulation TNF INS 18434880 1900265 *inhibits* [tumor necrosis factor-alpha] induction in myocardial ischemia/reperfusion : role of Akt and endothelial nitric oxide synthase phosphorylation . Negative_regulation TNF INS 18434880 1900267 In cultured cardiomyocytes subjected to SI/R , *reduced* [TNF-alpha] induction and increased Akt and endothelial nitric oxide synthase (eNOS) phosphorylation and subsequent nitric oxide ( NO ) production . Negative_regulation TNF INS 18434880 1900272 Our data showed that *inhibits* ischemia/reperfusion induced [TNF-alpha] production through the Akt activated and eNOS-NO dependent pathway in cardiomyocytes . Negative_regulation TNF INS 18840784 2012944 At 24 h of reperfusion , TDZD-8 and significantly *reduced* plasma levels of [tumor necrosis factor-alpha] ; Negative_regulation TNF INS 21841492 2500840 LY294002 reversed *mediated* downregulation of [tumor necrosis factor] . Negative_regulation TNF INS 23116663 2717435 Increased glucose and had no effect on base-line activin A secretion by BMNPs in culture , but pre-treatment with insulin *blocked* the [TNF-a] induced release of activin A . Negative_regulation TNF INS 3889459 49027 Insulin addition to the culture medium caused inhibition of TNF production from PEC , which indicated that may *block* [TNF] production from macrophages . Negative_regulation TNF INSR 15358232 1293404 [TNF-alpha] is linked with insulin resistance , as greater amounts of TNF are detected in muscle and adipose tissue in glycemically challenged people and TNF-alpha *inhibits* signalling . Negative_regulation TNF INSR 8617880 353905 The aim of the present study was to characterize the mechanism of TNF-alpha induced insulin receptor inhibition and to compare the consequences of [TNF-alpha-] and hyperglycemia induced *inhibition* for signal transduction downstream from the IR . Negative_regulation TNF IRAK1 12620219 1066172 Furthermore , recent data imply a *role* for in [tumor necrosis factor receptor (TNFR)] superfamily induced signaling pathways as well . Negative_regulation TNF IRAK3 19561104 2104171 Inhibition of in acute alcohol exposed monocytes using small interfering RNA *restored* the LPS induced [TNF-alpha] production whereas over-expression of IRAK-M in chronic alcohol macrophages prevented the increase in TNF-alpha production . Negative_regulation TNF IRAK3 22886503 2677778 Surfactant mediated upregulation of in macrophages *suppresses* TLR4 mediated [TNF-a] and IL-6 production in response to LPS , and IRAK-M knockdown by small interfering RNA reverses this suppression . Negative_regulation TNF IRAK4 9658753 517162 Conversely , neutralization of endogenous IL-10 was found to augment both [tumor necrosis factor-alpha] and IL-1 beta production and *inhibit* antagonist production . Negative_regulation TNF IRF1 14708625 1181175 Both tumor necrosis factor-alpha and interferon-gamma induced gene transcription , as assessed by the measurement of unspliced , nascent , heterogeneous nuclear RNA , and treatment with iron chelators *blocked* [tumor necrosis factor-alpha] or interferon-gamma mediated interferon regulatory factor-1 gene transcription . Negative_regulation TNF IRF1 18802049 1964491 Moreover , overexpression of and IRF-8 *induces* [TNF-alpha] production in unstimulated RAW 264.7 macrophages , comparable to the production of TNF-alpha elicited by IFN-gamma stimulation , and silencing of IRF-1 and/or IRF-8 with specific small interfering RNAs , decreases IFN-gamma elicited TNF-alpha production . Negative_regulation TNF IRF5 20237317 2265971 In this study , we define the *role* for in secretion of [tumor necrosis factor (TNF)] by human dendritic cells (DCs) . Negative_regulation TNF IRF8 18802049 1964490 Moreover , overexpression of IRF-1 and *induces* [TNF-alpha] production in unstimulated RAW 264.7 macrophages , comparable to the production of TNF-alpha elicited by IFN-gamma stimulation , and silencing of IRF-1 and/or IRF-8 with specific small interfering RNAs , decreases IFN-gamma elicited TNF-alpha production . Negative_regulation TNF IRG1 23609450 2795277 significantly *suppressed* TLR triggered production of proinflammatory cytokines [TNF-a] , IL-6 , and IFN-ß in LPS tolerized macrophages , with the elevated expression of reactive oxygen species ( ROS ) and A20 . Negative_regulation TNF ISL1 19169644 2061123 markedly *suppressed* LPS induced NO , IL-1beta , and [TNF-alpha] production . Negative_regulation TNF ISL2 19169644 2061122 markedly *suppressed* LPS induced NO , IL-1beta , and [TNF-alpha] production . Negative_regulation TNF ITGA6 8871661 389611 Cross linking of adherent PMN very late antigen (VLA)-5 and receptors *resulted* in a progressive increase in [TNF-alpha] ( p60 , p80 ) and IL-8R expression during hypoxia ; Negative_regulation TNF ITGAL 8104219 229036 It is noteworthy that the Kp43 mediated production of [TNF-alpha] was partially *inhibited* by anti-CD18 , and anti-ICAM-1 mAb that blocked LFA-1 dependent cellular interactions , which impaired NK cell aggregation and , moreover , was dependent on the presence of extracellular Mg2+ , thus suggesting that the leukocyte integrin is involved in the activation process triggered through Kp43 . Negative_regulation TNF ITGAL 9712747 527378 Furthermore , Northern blot analyses showed that the fimbria induced expression of IL-1beta and [TNF-alpha] genes in the cells was *inhibited* strongly by CD18 antibody treatment and slightly by , CD11b , or CD11c antibody treatment . Negative_regulation TNF ITGAM 9712747 527379 Furthermore , Northern blot analyses showed that the fimbria induced expression of IL-1beta and [TNF-alpha] genes in the cells was *inhibited* strongly by CD18 antibody treatment and slightly by CD11a , , or CD11c antibody treatment . Negative_regulation TNF ITGB2 8104219 229037 It is noteworthy that the Kp43 mediated production of [TNF-alpha] was partially *inhibited* by , anti-CD11a and anti-ICAM-1 mAb that blocked LFA-1 dependent cellular interactions , which impaired NK cell aggregation and , moreover , was dependent on the presence of extracellular Mg2+ , thus suggesting that the leukocyte integrin is involved in the activation process triggered through Kp43 . Negative_regulation TNF ITGB2 8603986 352324 also *prevented* acute lethality induced by one of the main mediators of endotoxin shock , [TNF-alpha] . Negative_regulation TNF ITGB2 8757962 377783 [TNF-alpha] but not IFN-gamma was detected in the supernatant of co-culture between KC and AH70 cells , and this production was partially *inhibited* by anti-ICAM-1 and . Negative_regulation TNF ITGB2 9759893 536639 As expected , cross linking of on macrophages with Ab *resulted* in generation of [TNF-alpha] and MIP-2 . Negative_regulation TNF ITIH4 23100517 2699073 Specifically , *inhibited* the CpG induced maturation of pDCs and their expression of [TNF-a] , IL-6 , TLR9 , IFN regulatory factor 7 , and BAFF . Negative_regulation TNF ITIH4 9343827 459047 CRDS treatment of cells not only inhibited the binding of HIV-1 to CD4+ cells , but also *inhibited* [TNF-alpha] production induced by gp120 . Negative_regulation TNF ITLN1 22554771 2608576 ( 300ng/ml , 30min ) *inhibited* [TNF-a] ( 1h ) -induced nicotinamide adenine dinucleotide phosphate oxidase activity as determined by lucigenin assay . Negative_regulation TNF IVD 22168811 2568563 , at the two lowest concentrations of product , significantly *reduced* [TNF-a] production by PBMC cultures exposed to PWM compared with the in vitro digest control or native NEM . Negative_regulation TNF IVD 22168811 2568564 The suppression of [TNF-a] production in the *presence* of is promising for the use of NEM as a consumable anti-inflammatory product . Negative_regulation TNF JAG1 12055252 951818 B. burgdorferi activated p38 MAP kinase in vitro , and the use of a specific inhibitor *repressed* the spirochete induced production of [TNF-alpha] . Negative_regulation TNF JUN 11675405 873236 The increase in [TNF-alpha] was attenuated by both a p42/p44 inhibitor , PD098059 ( 10 ( -6 ) M ) , and a p38 inhibitor , SB203580 ( 10 ( -6 ) M ) , and binding activity was *inhibited* by PD098059 . Negative_regulation TNF JUN 14736953 1199590 We investigated the *role* of NF-kappa B and in [tumour necrosis factor alpha (TNF-alpha)] induced monocyte chemoattractant protein 1 ( MCP-1 ) production in cultured human glomerular endothelial cells ( HGEC ) . Negative_regulation TNF JUN 15313439 1285535 In view of the potential *role* of in the induction of [TNF-alpha] , we next examined the inhibitory effects of arctigenin on the expression of TNF-alpha . Negative_regulation TNF JUN 16365438 1504943 Furthermore , we present evidence that A238L *inhibits* the activation of [TNF-alpha] by modulating NF-kappaB , NF-AT , and trans activation through a mechanism that involves CREB binding protein/p300 function , because overexpression of these transcriptional coactivators recovers TNF-alpha promoter activity . Negative_regulation TNF JUN 18302884 1873511 To study the *role* of in the up-regulation expression of [tumor necrosis factor-alpha (TNF-alpha)] and transforming growth factor-beta1 ( TGF-beta(1) ) in silica stimulated macrophage cells ( RAW264.7 ) . Negative_regulation TNF JUN 19043087 2035342 The aim of this study was to investigate the *role* of signalling in cardiomyocyte [TNF-alpha] expression during lipopolysaccharide (LPS) stimulation and myocardial function in endotoxaemic mice . Negative_regulation TNF JUN 19748795 2153100 ZD 7155 also reduced the mRNA expression of [TNF-alpha] and IL-1 beta , *inhibited* the activation of NF-kappaB and , and improved lung histopathology . Negative_regulation TNF JUN 19874421 2488983 Cells expressing a PI3K mutant ( p85-dominant negative , DN ; p85 ?478-511 ) and exposed to Pam ( 3 ) -Cys-Ser-Lys ( 4 ) in the presence or absence of dexamethasone , showed *enhanced* tumour necrosis factor ( [TNF] ) a expression while and NF-?B transcriptional activity were repressed . Negative_regulation TNF JUN 20663042 2298138 These results indicated that the downregulation of [TNF-alpha] by S. tenuifolia water extract may have *involved* the inhibition of both IkappaBalpha degradation and activation of and ATF-2 involving suppression of JNK/SAPK . Negative_regulation TNF JUN 21849907 2496017 Its suppressive effect on [TNF-a] , I-309 , and IP-10 may , at least in part , *involve* the down-regulation of LPS induced expression . Negative_regulation TNF JUN 7635431 317116 Using primary cultures of rat Kupffer cells the *role* of NF-kappa B and in the expression of the [tumor necrosis factor-alpha (TNF-alpha)] gene by lipopolysaccharide (LPS) was investigated . Negative_regulation TNF JUND 10858536 730023 Whilst the expression of was not affected by any of the mediators , the mRNA levels of c-fos and JunB were *induced* by LPS , IL-6 , IFN-gamma , PDGF and [TNF-alpha] , and that of c-jun by LPS , IFN-gamma , PDGF and TNF-alpha . Negative_regulation TNF KISS1R 19201817 2061380 Activation of *resulted* in the ERK dependent expression of [tumor necrosis factor-alpha] and FasL in a lymphoid cell line , the latter being the main trigger of apoptosis . Negative_regulation TNF KLK3 19653348 2119077 APS did not block the activation of extracellular signal regulated kinase or c Jun amino-terminal kinase , but inhibited the activation of p38 , suggesting that *inhibits* LPS induced production of [TNF-alpha] and IL-8 mRNAs , possibly by suppressing the p38 signaling pathway . Negative_regulation TNF KLK3 22410422 2567033 Mechanistic studies indicated that APS strongly suppressed NF-?B activation and down-regulated the phosphorylation of ERK and JNK , which are important signaling pathways involved in the production of TNF-a and IL-1ß , demonstrating that could *suppress* the production of [TNF-a] and IL-1ß by LPS stimulated macrophages by inhibiting NF-?B activation and ERK and JNK phosphorylation . Negative_regulation TNF KLRB1 18453569 1909059 Interactions between on NK cells and LLT1 on target cells inhibit NK cell mediated cytotoxicity and cytokine production and can *inhibit* [TNF-alpha] production by TCR activated NKR-P1A ( + ) CD8 ( + ) T cells . Negative_regulation TNF KLRC1 18096998 1847469 [TNF] production by antiviral CD8+ T cells was significantly *enhanced* by blockade in vitro , and mice deficient in the NKG2A ligand , Qa-1b , manifested significantly greater pulmonary pathology upon CD8+ T cell mediated clearance in influenza pneumonia . Negative_regulation TNF KRT10 12813371 1103130 The effects of K/X appear to inhibit transcriptional events in iNOS expression , which may be dependent on *induced* inhibition of early [TNF-alpha] expression . Negative_regulation TNF KRT14 9343182 458908 Further , <10.4K/14.5K> , which was previously shown to protect against TNF cytolysis , does not *induce* a loss of [TNF] receptor , indicating that this complex mediates more than one function to block host defense mechanisms . Negative_regulation TNF LAMTOR3 15935330 1420748 also significantly *reduced* the expression of TLR4 , [TNF-alpha] and IL-6 mRNA and the release of cytokines in LPS stimulated murine peritoneal macrophages . Negative_regulation TNF LANCL1 12871593 1114118 The present study was undertaken to explore the *role* of interleukin-12 (IL-12) in the expression of [TNF-alpha] in microglia . Negative_regulation TNF LBH 21102427 2377302 also significantly *repressed* the production of interleukin (IL)-6 , IL-10 , IL-12p70 , IL-23 and [tumor necrosis factor-a] by Toll-like receptor (TLR)3 and TLR4 induced DC activation , indicating an important role of HDAC activity in immune regulation and inflammation . Negative_regulation TNF LBP 12198381 982190 To determine the pathophysiological roles of macrophages in alcoholic liver disease , we examined the effect of ethanol on [TNF-alpha] secretion of rat Kupffer cells , alveolar macrophages , and peritoneal macrophages in the *presence* or absence of . Negative_regulation TNF LBP 1607653 189303 In contrast , did not enhance or *inhibit* [TNF] production produced by heat killed Staphylococcus aureus , peptidoglycan isolated from S. aureus cell walls , or PMA . Negative_regulation TNF LBP 7685250 219750 Therefore , in the airspace *enhances* the LPS effect on [TNF-alpha] production via a CD14 dependent pathway , and as a result , CD14 activation can contribute to lung PMN sequestration . Negative_regulation TNF LBP 9725255 529650 We have demonstrated that , unlike the human monocyte response to LPS , both and BPI *inhibited* LPS stimulated [TNF-alpha] production in mouse peritoneal macrophages . Negative_regulation TNF LDHB 14586559 1187180 Contrary to this , in PBMC of NHL patients prior to therapy [TNF-alpha] *induced* a significant decrease ( p < 0.05 ) of isotype activity . Negative_regulation TNF LEO1 1873355 165234 Further , the *role* of released in response to a challenge with LPS in the regulation of [TNF] and IL-6 production was investigated . Negative_regulation TNF LEO1 8514698 221949 Repeated dosing also *resulted* in sustained increased serum [tumor necrosis factor-alpha] levels ( 1,610 +/- 470 pg/ml , P < 0.01 ) and further exacerbation of the leukopenia ( -68 +/- 6 % , P < 0.01 ) and thrombocytopenia ( -65 +/- 8 % , P < 0.01 ) . Negative_regulation TNF LEO1 9403541 469607 Furthermore , inhibiting production with AACOCF3 , or manoalide , also *inhibited* LPS induced Mphi [TNF] mRNA expression . Negative_regulation TNF LEP 10681432 669145 These results demonstrate that deficiency *leads* to reduced production of [TNF-alpha] and IL-18 associated with reduced T cell mediated hepatotoxicity . Negative_regulation TNF LEP 16298137 1493937 Interaction between [tumor necrosis factor-alpha] and induced *inhibition* of cardiac contractile function in isolated ventricular myocytes . Negative_regulation TNF LEP 19615431 2182842 Neonatal parathion exposure uncoupled serum levels from their dependence on body weight , *suppressed* adiponectin and elevated [TNFalpha] in white adipose tissue . Negative_regulation TNF LEPR 20607056 2286356 Effect of leptin on P. intermedia LPS induced [TNF-alpha] production was not *mediated* by the . Negative_regulation TNF LGALS1 10655263 663490 In addition , almost completely *prevented* the Con A-induced increase in plasma [TNF-alpha] and IFN-gamma , an effect that was , at least in part , independent on the elimination of activated T helper cells , because galectin-1 prevented lipopolysaccharide (LPS) induced release of TNF-alpha and IFN-gamma also from macrophages in vitro , without affecting their viability . Negative_regulation TNF LGALS9 17560833 1767653 The fact that does not *suppress* LPS induced [TNF-alpha] , IFN-gamma and IL-12 production in neutropenic mice , and that it does not protect those mice from the Shwartzman reaction , confirms the involvement of PMN in regulation . Negative_regulation TNF LIF 18771807 2000512 *inhibits* the production of oxygen radicals and [TNFalpha] and stimulates myelin uptake by macrophages . Negative_regulation TNF LIG1 22760256 2701014 significantly *inhibited* OVX induced up-regulation of NF-?B activation and the production of IL-1ß , [TNF-a] , iNOS , ICAM-1 and COX-2 . Negative_regulation TNF LIG3 22760256 2701015 significantly *inhibited* OVX induced up-regulation of NF-?B activation and the production of IL-1ß , [TNF-a] , iNOS , ICAM-1 and COX-2 . Negative_regulation TNF LIG4 22760256 2701016 significantly *inhibited* OVX induced up-regulation of NF-?B activation and the production of IL-1ß , [TNF-a] , iNOS , ICAM-1 and COX-2 . Negative_regulation TNF LILRB4 19833736 2169984 Treatment of cells with a broad-spectrum phosphatase inhibitor , sodium pervanadate ( SP ) , significantly reversed *mediated* inhibition of [TNFalpha] production and protein tyrosine phosphorylation . Negative_regulation TNF LIPG 23256442 2724703 Moreover , *led* to a significant decrease in the serum levels of ALT , hepatic TG , and MDA , and in the expression levels of [TNF-a] , and IL-6 ; Negative_regulation TNF LITAF 15025820 1222451 Taken together , these results highlight the important *role* of in the regulation of [TNF-alpha] gene expression and suggest a potential role of LITAF in mouse organogenesis . Negative_regulation TNF LITAF 24091064 2874528 Overexpression of in vitro *up-regulated* the expression of tumor necrosis factors ( [TNF1] and TNF2 ) and TNF receptors ( TNFR1 and TNFR2 ) , and the expression of itself initiated apoptosis in fish cells . Negative_regulation TNF LNPEP 8384689 214800 FGF stimulated TNF alpha induced PGE2 production independent of potential TNF alpha mediated IL-1 production , as neither anti-IL-1 mAbs nor *inhibited* [TNF alpha] induced-PGE2 production or the stimulatory effect of FGF . Negative_regulation TNF LPA 12370341 995826 However , *inhibited* in a pertussis toxin-insensitive manner the secretion of IL-12 and [TNFalpha] as well as enhanced secretion of IL-10 from mature DCs . Negative_regulation TNF LPA 18431464 1932526 ( 1 and 10 microM ) significantly *inhibited* LPS induced [TNFalpha] production ( 61 +/- 9 % and 72 +/- 9 % , respectively , P < 0.05 ) but not IL-6 . Negative_regulation TNF LPA 19132242 2005588 Unexpectedly , the modified not only failed to activate NF-kappaB , but completely *blocked* its activation by [tumour necrosis factor-alpha (TNF-alpha)] in EA.hy926-cells , as assessed by electrophoretic mobility shift assays and immunofluorescence . Negative_regulation TNF LPA 22241121 2519616 High-density *prevents* SAA induced production of [TNF-a] in THP-1 monocytic cells and peripheral blood mononuclear cells . Negative_regulation TNF LPA 7475000 326637 Reconstituted high-density *reduces* LPS stimulated [TNF alpha] . Negative_regulation TNF LPA 7475000 326639 Reconstituted high-density lipoprotein ( rHDL ) , an artificial consisting of apolipoprotein A-I and phosphatidylcholine ( 1 : 150 , molar ratios ) dose-dependently *reduces* lipopolysaccharide (LPS) induced [tumor necrosis factor-alpha (TNF)] production in in vitro , ex-vivo , and in-vivo model systems . Negative_regulation TNF LPA 8304830 249016 Reconstituted high density *inhibits* physiologic and [tumor necrosis factor] alpha responses to lipopolysaccharide in rabbits . Negative_regulation TNF LPA 8324886 223317 A reconstituted , apolipoprotein A-I containing *reduces* [tumor necrosis factor] release and attenuates shock in endotoxemic rabbits . Negative_regulation TNF LPA 8690807 372651 Oxidized low density *inhibits* lipopolysaccharide induced binding of nuclear factor-kappaB to DNA and the subsequent expression of [tumor necrosis factor-alpha] and interleukin-1beta in macrophages . Negative_regulation TNF LPL 7583927 333600 TSST-1 stimulation of *resulted* in IL-2 and [TNF] production but no IL-4 , IL-6 , or gamma interferon . Negative_regulation TNF LPL 9278582 451395 [TNF] is expressed at higher levels in muscle cells of insulin-resistant subjects , and TNF may *inhibit* expression . Negative_regulation TNF LRRFIP1 16199883 1463496 *represses* [tumor necrosis factor] alpha expression . Negative_regulation TNF LSS 19122175 2037071 The finding that *dependent* reduction of [TNF-alpha] generation and HO-1 induction were abrogated by the selective inhibitor of COX-2 NS-398 , the nonselective COX inhibitor aspirin , or the specific prostacyclin receptor ( IP ) antagonist RO3244794 illuminates the central role played by LSS induced COX-2 dependent prostacyclin in restraining endothelial inflammation . Negative_regulation TNF LTA 18501625 1928138 We found that ApoA-I could attenuate induced acute lung injury and inflammation and significantly *inhibit* LTA induced IL-1beta and [TNF-alpha] accumulation in the serum ( P < 0.01 and P < 0.05 , respectively ) , as well as in bronchoalveolar lavage (BAL) fluid ( P < 0.01 and P < 0.05 , respectively ) . Negative_regulation TNF LTA 18600067 1935497 Here , we demonstrate that highly purified ( pLTA ) isolated from Lactobacillus plantarum *inhibited* aureus LTA ( aLTA ) -induced [TNF-alpha] production in THP- cells . Negative_regulation TNF LTA 18845389 2012989 Upon exposure to LTA purified from Staphylococcus aureus , [TNF-alpha] expression was substantially *induced* , whereas pretreatment with PhIP significantly inhibited induced TNF-alpha expression . Negative_regulation TNF LTA 22956655 2688280 Anti-inflammatory SMAMPs prevented the induction of [tumor necrosis factor (TNF)] , interleukin 6 (IL-6) , and IL-10 in *response* to S. aureus or , but no other TLR2 ligands . Negative_regulation TNF LTA 3001529 54311 The binding of labelled [TNF-alpha] to these cells can be *inhibited* by both TNF-alpha and but not by gamma-interferon ( IFN-gamma ) . Negative_regulation TNF LTA 8381771 212015 The binding of labeled [TNF-alpha] to these bacterial receptors can be *inhibited* by cold TNF-alpha but not by cold . Negative_regulation TNF LTA 9864375 556212 Membrane retention of *resulted* indeed in receptor downmodulation and [TNF/LT-alpha] resistance . Negative_regulation TNF LTB 24446972 2918155 Homoisoflavanone down-regulated PGD2 , , and LTC4 production and *inhibited* the production of pro-inflammatory cytokines , such as interleukin-6 and [tumor necrosis factor-a] in PMA/A23187- or IgE/antigen stimulated mast cells . Negative_regulation TNF LTB 2540688 110421 We next examined the *role* of in mineral-dust induced [TNF] production . Negative_regulation TNF LTB 9126704 426577 These results demonstrate that PGE2 does not affect , IL-4 , or IL-3 in Th2 cells , but *inhibits* [TNF] mRNA accumulation and production in this T cell subset . Negative_regulation TNF LTF 10202564 606114 increases the output of neutrophil precursors and *attenuates* the spontaneous production of [TNF-alpha] and IL-6 by peripheral blood cells . Negative_regulation TNF LTF 10580998 570180 itself did not induce either tumor necrosis factor-alpha production or nitric oxide production , but lipopolysaccharide stimulated [tumor necrosis factor-alpha] production of macrophages and monocytes were *inhibited* by lactoferrin treatment combined with stimulant . Negative_regulation TNF LYZ 8508690 221548 Only minor effects on macrophage functions were observed when cells were treated with therapeutic concentrations of ACV : phagocytosis and the production of interferon and [tumor necrosis factor] were slightly *enhanced* , while the production of was reduced , in a dose dependent manner . Negative_regulation TNF MADD 10521481 653125 Furthermore , overexpression of ( MAP kinase activating death domain protein ) , an adapter protein that binds to the death domain of TNFR1 and activates MAP kinase cascades , *results* in CRE dependent induction of [TNF-alpha] gene expression . Negative_regulation TNF MAFA 21059644 2370948 In contrast , the ß-cell-specific transcriptional activator could *repress* NFAT mediated [TNF-a] gene expression whenever C/EBP-ß was bound to the promoter . Negative_regulation TNF MAK 10736094 679348 Using neutralization with an anti TNF-alpha MoAb MAK195 , EAF is not identical with TNF-alpha , but *induces* the expression of endothelial [TNF-alpha] , since blocked TEM only when coincubated with EC , not with monocytes . Negative_regulation TNF MALT1 8869096 389302 Previous clinical studies have suggested that the pineal hormone , which plays an essential role in the neuroendocrine regulation of biological systems , may improve the clinical status of advanced cancer patients and *inhibit* [TNF] secretion . Negative_regulation TNF MAP2K1 11520792 852346 The MAPK kinase ( inhibitor PD98059 *reduced* LPS induction of TF and [TNF-alpha] expression in a dose dependent manner . Negative_regulation TNF MAP2K1 12485415 1032930 CRH effects on [TNF-alpha] release were also *inhibited* by specific inhibitors of , the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 mitogen activated protein kinase ( SB203580 ) , but not by H89 . Negative_regulation TNF MAP2K2 12485415 1032931 CRH effects on [TNF-alpha] release were also *inhibited* by specific inhibitors of , the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 mitogen activated protein kinase ( SB203580 ) , but not by H89 . Negative_regulation TNF MAP2K3 10580119 569977 Anthrax lethal factor cleaves in macrophages and *inhibits* the LPS/IFNgamma induced release of NO and [TNFalpha] . Negative_regulation TNF MAP2K3 12485415 1032932 CRH effects on [TNF-alpha] release were also *inhibited* by specific inhibitors of , the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 mitogen activated protein kinase ( SB203580 ) , but not by H89 . Negative_regulation TNF MAP2K4 12485415 1032933 CRH effects on [TNF-alpha] release were also *inhibited* by specific inhibitors of , the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 mitogen activated protein kinase ( SB203580 ) , but not by H89 . Negative_regulation TNF MAP2K4 21849907 2496018 Its suppressive effect on [TNF-a] , I-309 , and IP-10 may , at least in part , *involve* the down-regulation of LPS induced expression . Negative_regulation TNF MAP2K5 11274363 797644 *Role* of in the regulation of [TNF-alpha] gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells . Negative_regulation TNF MAP2K5 12485415 1032934 CRH effects on [TNF-alpha] release were also *inhibited* by specific inhibitors of , the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 mitogen activated protein kinase ( SB203580 ) , but not by H89 . Negative_regulation TNF MAP2K6 12485415 1032935 CRH effects on [TNF-alpha] release were also *inhibited* by specific inhibitors of , the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 mitogen activated protein kinase ( SB203580 ) , but not by H89 . Negative_regulation TNF MAP2K7 12485415 1032936 CRH effects on [TNF-alpha] release were also *inhibited* by specific inhibitors of , the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 mitogen activated protein kinase ( SB203580 ) , but not by H89 . Negative_regulation TNF MAP3K2 11274363 797645 *Role* of in the regulation of [TNF-alpha] gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells . Negative_regulation TNF MAP3K3 12065326 954387 Gab1 associated with MEKK3 , and a catalytically inactive form of MEKK3 inhibited TNF-alpha induced c-Jun and NF-kappaB transcriptional activation , suggesting a critical *role* for Gab1 and in [TNF-alpha] signaling . Negative_regulation TNF MAP3K5 15696199 1382715 In cultured ECs , reduction of TXNIP expression by small interfering RNA increased TRX binding to and *inhibited* [TNF] activation of JNK/p38 and VCAM1 expression . Negative_regulation TNF MAP3K7 17052891 1683801 In this study , a critical *role* for in IL-1alpha or [TNFalpha] stimulated MAPK and NFkappaB activation was confirmed by inhibition of the nuclear accumulation of NFkappaB p65 and phosphorylated forms of c-Jun and p38 following siRNA mediated TAK1 silencing . Negative_regulation TNF MAP3K8 20606319 2286344 Although the TNFalpha mRNA level was not altered by either inhibitor , the inhibitor *increased* the nuclear [TNFalpha] mRNA level , while decreasing that in the cytoplasm . Negative_regulation TNF MAPK1 10079106 595546 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Negative_regulation TNF MAPK1 10620700 657626 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Negative_regulation TNF MAPK1 10655266 663494 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Negative_regulation TNF MAPK1 10657669 664172 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Negative_regulation TNF MAPK1 10783388 707805 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Negative_regulation TNF MAPK1 11179444 784693 [TNF-alpha-] or C2-ceramide induced COX-2 promoter activity was *inhibited* by the dominant negative mutant of , p38 , JNK , IkappaB kinase (IKK)1 , or IKK2 . Negative_regulation TNF MAPK1 11299196 803148 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Negative_regulation TNF MAPK1 11299196 803214 SB203580 inhibited p38 activity , *reduced* myocyte secretion of [TNF-alpha] , and prevented burn mediated cardiac deficits . Negative_regulation TNF MAPK1 11699878 878360 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Negative_regulation TNF MAPK1 11715476 581254 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Negative_regulation TNF MAPK1 11815388 907603 These results indicate that the MAPK pathway and *mediated* regulation of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Negative_regulation TNF MAPK1 12485415 1032937 CRH effects on [TNF-alpha] release were also *inhibited* by specific inhibitors of MEK , the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 ( SB203580 ) , but not by H89 . Negative_regulation TNF MAPK1 12506117 1056910 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Negative_regulation TNF MAPK1 12559181 1052100 It was concluded that pretranscriptional regulation of [TNF] gene expression in Kupffer cells *follows* an orderly activation of , ERK1/2 , and SAPK/JNK that may not converge on NF-kappaB . Negative_regulation TNF MAPK1 12760489 895610 However , a specific inhibitor of p38 , SB203580 , *had* no effect on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Negative_regulation TNF MAPK1 15519192 1328819 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial [TNFalpha] mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as TNFalpha production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 activation . Negative_regulation TNF MAPK1 15557189 1340393 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Negative_regulation TNF MAPK1 16480618 1496049 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Negative_regulation TNF MAPK1 16480618 1496088 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Negative_regulation TNF MAPK1 16581537 1543720 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Negative_regulation TNF MAPK1 16946004 1639277 Finally , the blocking of p44/42 activation *prevented* [TNFalpha] inhibition of FSH dependent increases in P450AROM and inhibin alpha-subunit mRNA levels , thus indicating that p44/42 MAPK mediated ICER expression may be accountable for the effects of TNFalpha on the expression of both proteins . Negative_regulation TNF MAPK1 18246004 1839558 Blocking cytokine activation of p38 *reduced* IL-1 and [TNF-alpha] induced PGE2 and IL-6 accumulation . Negative_regulation TNF MAPK1 18559343 1952537 OxPAPC inhibited [tumor necrosis factor-alpha] production , IkappaBalpha degradation , p38 phosphorylation , and NF-kappaB dependent reporter activation *induced* by stimulants of TLR2 and TLR4 ( Pam3CSK4 and LPS ) but not by stimulants of other TLRs ( poly ( I.C ) , flagellin , loxoribine , single stranded RNA , or CpG DNA ) in macrophages and HEK-293 cells transfected with respective TLRs and significantly reduced inflammatory responses in mice injected subcutaneously or intraperitoneally with Pam3CSK4 . Negative_regulation TNF MAPK1 18675993 2011214 The role of P38 and PKC in BLP *induced* [TNF-alpha] release , apoptosis , and NFkappaB activation in THP-1 monocyte cells . Negative_regulation TNF MAPK1 18675993 2011298 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Negative_regulation TNF MAPK1 19052649 1999767 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Negative_regulation TNF MAPK1 19086324 2000255 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 and NF-kappaB activities , and then [TNF-alpha] overexpression , thus alleviating the inflammatory reaction . Negative_regulation TNF MAPK1 19118509 2004779 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and [TNF-alpha] and *inhibited* the phosphorylation of Akt , PKCdelta and p38 . Negative_regulation TNF MAPK1 19450605 2096895 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 and *inhibited* cardiac [TNF-alpha] expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation TNF MAPK1 19493203 2091408 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Negative_regulation TNF MAPK1 21147093 2378240 LPS induced phosphorylation of I?Ba and p38 was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and [TNF-a] production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation TNF MAPK1 21208554 2374400 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Negative_regulation TNF MAPK1 23056531 2685366 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit [tumor necrosis factor] a ( TNF-a production in cultured macrophages ) and in vitro p38a *inhibition* . Negative_regulation TNF MAPK1 23518420 2777183 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and [TNF-a] protein expression in the kidney , as well as *inhibiting* signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation TNF MAPK1 24152910 2875214 It was found that thrombin down-regulates the HMGB1 mediated induction of both [TNF-a] and IL-6 and *inhibits* the activation of both p38 and NF-?B in HUVECs pretreated with PC . Negative_regulation TNF MAPK1 24997655 2952764 We conclude that exposure to PRL *increases* [TNF-a] release from CD14 ( + ) monocytes of RA patients , which can be abolished by PRLR gene silencing or treating with inhibitor . Negative_regulation TNF MAPK1 9418855 480510 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Negative_regulation TNF MAPK1 9439626 482852 Tyrosine kinase and *inhibition* of [TNF-alpha-] and EGF stimulated IEC-6 cell growth . Negative_regulation TNF MAPK1 9864164 582626 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Negative_regulation TNF MAPK10 10079106 595547 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Negative_regulation TNF MAPK10 10620700 657627 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Negative_regulation TNF MAPK10 10655266 663495 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Negative_regulation TNF MAPK10 10657669 664173 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Negative_regulation TNF MAPK10 10783388 707806 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Negative_regulation TNF MAPK10 11299196 803149 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Negative_regulation TNF MAPK10 11299196 803215 SB203580 inhibited p38 activity , *reduced* myocyte secretion of [TNF-alpha] , and prevented burn mediated cardiac deficits . Negative_regulation TNF MAPK10 11699878 878361 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Negative_regulation TNF MAPK10 11715476 581255 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Negative_regulation TNF MAPK10 11815388 907604 These results indicate that the MAPK pathway and *mediated* regulation of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Negative_regulation TNF MAPK10 12485415 1032938 CRH effects on [TNF-alpha] release were also *inhibited* by specific inhibitors of MEK , the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 ( SB203580 ) , but not by H89 . Negative_regulation TNF MAPK10 12506117 1056911 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Negative_regulation TNF MAPK10 12559181 1052101 It was concluded that pretranscriptional regulation of [TNF] gene expression in Kupffer cells *follows* an orderly activation of , ERK1/2 , and SAPK/JNK that may not converge on NF-kappaB . Negative_regulation TNF MAPK10 12760489 895611 However , a specific inhibitor of p38 , SB203580 , *had* no effect on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Negative_regulation TNF MAPK10 15519192 1328820 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial TNFalpha mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as [TNFalpha] production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 activation . Negative_regulation TNF MAPK10 15557189 1340394 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Negative_regulation TNF MAPK10 16480618 1496050 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Negative_regulation TNF MAPK10 16480618 1496089 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Negative_regulation TNF MAPK10 16581537 1543721 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Negative_regulation TNF MAPK10 16946004 1639278 Finally , the blocking of p44/42 activation *prevented* [TNFalpha] inhibition of FSH dependent increases in P450AROM and inhibin alpha-subunit mRNA levels , thus indicating that p44/42 MAPK mediated ICER expression may be accountable for the effects of TNFalpha on the expression of both proteins . Negative_regulation TNF MAPK10 18246004 1839559 Blocking cytokine activation of p38 *reduced* IL-1 and [TNF-alpha] induced PGE2 and IL-6 accumulation . Negative_regulation TNF MAPK10 18559343 1952538 OxPAPC inhibited [tumor necrosis factor-alpha] production , IkappaBalpha degradation , p38 phosphorylation , and NF-kappaB dependent reporter activation *induced* by stimulants of TLR2 and TLR4 ( Pam3CSK4 and LPS ) but not by stimulants of other TLRs ( poly ( I.C ) , flagellin , loxoribine , single stranded RNA , or CpG DNA ) in macrophages and HEK-293 cells transfected with respective TLRs and significantly reduced inflammatory responses in mice injected subcutaneously or intraperitoneally with Pam3CSK4 . Negative_regulation TNF MAPK10 18675993 2011215 The role of P38 and PKC in BLP *induced* [TNF-alpha] release , apoptosis , and NFkappaB activation in THP-1 monocyte cells . Negative_regulation TNF MAPK10 18675993 2011299 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Negative_regulation TNF MAPK10 19052649 1999768 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Negative_regulation TNF MAPK10 19086324 2000256 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 and NF-kappaB activities , and then [TNF-alpha] overexpression , thus alleviating the inflammatory reaction . Negative_regulation TNF MAPK10 19118509 2004780 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and [TNF-alpha] and *inhibited* the phosphorylation of Akt , PKCdelta and p38 . Negative_regulation TNF MAPK10 19450605 2096896 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 and *inhibited* cardiac [TNF-alpha] expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation TNF MAPK10 19493203 2091409 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Negative_regulation TNF MAPK10 21147093 2378241 LPS induced phosphorylation of I?Ba and p38 was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and [TNF-a] production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation TNF MAPK10 21208554 2374401 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Negative_regulation TNF MAPK10 23056531 2685367 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit [tumor necrosis factor] a ( TNF-a production in cultured macrophages ) and in vitro p38a *inhibition* . Negative_regulation TNF MAPK10 23518420 2777184 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and [TNF-a] protein expression in the kidney , as well as *inhibiting* signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation TNF MAPK10 24152910 2875215 It was found that thrombin down-regulates the HMGB1 mediated induction of both [TNF-a] and IL-6 and *inhibits* the activation of both p38 and NF-?B in HUVECs pretreated with PC . Negative_regulation TNF MAPK10 24997655 2952765 We conclude that exposure to PRL *increases* [TNF-a] release from CD14 ( + ) monocytes of RA patients , which can be abolished by PRLR gene silencing or treating with inhibitor . Negative_regulation TNF MAPK10 9418855 480511 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Negative_regulation TNF MAPK10 9439626 482853 Tyrosine kinase and *inhibition* of [TNF-alpha-] and EGF stimulated IEC-6 cell growth . Negative_regulation TNF MAPK10 9864164 582627 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Negative_regulation TNF MAPK11 10079106 595548 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Negative_regulation TNF MAPK11 10620700 657628 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Negative_regulation TNF MAPK11 10655266 663496 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Negative_regulation TNF MAPK11 10657669 664174 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Negative_regulation TNF MAPK11 10783388 707807 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Negative_regulation TNF MAPK11 11299196 803150 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Negative_regulation TNF MAPK11 11299196 803216 SB203580 inhibited p38 activity , *reduced* myocyte secretion of [TNF-alpha] , and prevented burn mediated cardiac deficits . Negative_regulation TNF MAPK11 11699878 878362 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Negative_regulation TNF MAPK11 11715476 581256 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Negative_regulation TNF MAPK11 11815388 907605 These results indicate that the MAPK pathway and *mediated* regulation of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Negative_regulation TNF MAPK11 12485415 1032939 CRH effects on [TNF-alpha] release were also *inhibited* by specific inhibitors of MEK , the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 ( SB203580 ) , but not by H89 . Negative_regulation TNF MAPK11 12506117 1056912 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Negative_regulation TNF MAPK11 12559181 1052102 It was concluded that pretranscriptional regulation of [TNF] gene expression in Kupffer cells *follows* an orderly activation of , ERK1/2 , and SAPK/JNK that may not converge on NF-kappaB . Negative_regulation TNF MAPK11 12760489 895612 However , a specific inhibitor of p38 , SB203580 , *had* no effect on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Negative_regulation TNF MAPK11 15519192 1328821 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial [TNFalpha] mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as TNFalpha production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 activation . Negative_regulation TNF MAPK11 15557189 1340395 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Negative_regulation TNF MAPK11 16480618 1496051 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Negative_regulation TNF MAPK11 16480618 1496090 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Negative_regulation TNF MAPK11 16581537 1543722 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Negative_regulation TNF MAPK11 16946004 1639279 Finally , the blocking of p44/42 activation *prevented* [TNFalpha] inhibition of FSH dependent increases in P450AROM and inhibin alpha-subunit mRNA levels , thus indicating that p44/42 MAPK mediated ICER expression may be accountable for the effects of TNFalpha on the expression of both proteins . Negative_regulation TNF MAPK11 18246004 1839560 Blocking cytokine activation of p38 *reduced* IL-1 and [TNF-alpha] induced PGE2 and IL-6 accumulation . Negative_regulation TNF MAPK11 18559343 1952539 OxPAPC inhibited [tumor necrosis factor-alpha] production , IkappaBalpha degradation , p38 phosphorylation , and NF-kappaB dependent reporter activation *induced* by stimulants of TLR2 and TLR4 ( Pam3CSK4 and LPS ) but not by stimulants of other TLRs ( poly ( I.C ) , flagellin , loxoribine , single stranded RNA , or CpG DNA ) in macrophages and HEK-293 cells transfected with respective TLRs and significantly reduced inflammatory responses in mice injected subcutaneously or intraperitoneally with Pam3CSK4 . Negative_regulation TNF MAPK11 18675993 2011216 The role of P38 and PKC in BLP *induced* [TNF-alpha] release , apoptosis , and NFkappaB activation in THP-1 monocyte cells . Negative_regulation TNF MAPK11 18675993 2011300 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Negative_regulation TNF MAPK11 19052649 1999769 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Negative_regulation TNF MAPK11 19086324 2000257 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 and NF-kappaB activities , and then [TNF-alpha] overexpression , thus alleviating the inflammatory reaction . Negative_regulation TNF MAPK11 19118509 2004781 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and [TNF-alpha] and *inhibited* the phosphorylation of Akt , PKCdelta and p38 . Negative_regulation TNF MAPK11 19450605 2096897 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 and *inhibited* cardiac [TNF-alpha] expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation TNF MAPK11 19493203 2091410 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Negative_regulation TNF MAPK11 21147093 2378242 LPS induced phosphorylation of I?Ba and p38 was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and [TNF-a] production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation TNF MAPK11 21208554 2374402 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Negative_regulation TNF MAPK11 23056531 2685368 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit [tumor necrosis factor] a ( TNF-a production in cultured macrophages ) and in vitro p38a *inhibition* . Negative_regulation TNF MAPK11 23518420 2777185 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and [TNF-a] protein expression in the kidney , as well as *inhibiting* signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation TNF MAPK11 24152910 2875216 It was found that thrombin down-regulates the HMGB1 mediated induction of both [TNF-a] and IL-6 and *inhibits* the activation of both p38 and NF-?B in HUVECs pretreated with PC . Negative_regulation TNF MAPK11 24997655 2952766 We conclude that exposure to PRL *increases* [TNF-a] release from CD14 ( + ) monocytes of RA patients , which can be abolished by PRLR gene silencing or treating with inhibitor . Negative_regulation TNF MAPK11 9418855 480512 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Negative_regulation TNF MAPK11 9439626 482854 Tyrosine kinase and *inhibition* of [TNF-alpha-] and EGF stimulated IEC-6 cell growth . Negative_regulation TNF MAPK11 9864164 582628 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Negative_regulation TNF MAPK12 10079106 595549 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Negative_regulation TNF MAPK12 10620700 657629 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Negative_regulation TNF MAPK12 10655266 663497 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Negative_regulation TNF MAPK12 10657669 664175 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Negative_regulation TNF MAPK12 10783388 707808 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Negative_regulation TNF MAPK12 11299196 803151 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Negative_regulation TNF MAPK12 11299196 803217 SB203580 inhibited p38 activity , *reduced* myocyte secretion of [TNF-alpha] , and prevented burn mediated cardiac deficits . Negative_regulation TNF MAPK12 11699878 878363 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Negative_regulation TNF MAPK12 11715476 581257 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Negative_regulation TNF MAPK12 11815388 907606 These results indicate that the MAPK pathway and *mediated* regulation of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Negative_regulation TNF MAPK12 12485415 1032940 CRH effects on [TNF-alpha] release were also *inhibited* by specific inhibitors of MEK , the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 ( SB203580 ) , but not by H89 . Negative_regulation TNF MAPK12 12506117 1056913 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Negative_regulation TNF MAPK12 12559181 1052103 It was concluded that pretranscriptional regulation of [TNF] gene expression in Kupffer cells *follows* an orderly activation of , ERK1/2 , and SAPK/JNK that may not converge on NF-kappaB . Negative_regulation TNF MAPK12 12760489 895613 However , a specific inhibitor of p38 , SB203580 , *had* no effect on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Negative_regulation TNF MAPK12 15519192 1328822 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial TNFalpha mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as [TNFalpha] production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 activation . Negative_regulation TNF MAPK12 15557189 1340396 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Negative_regulation TNF MAPK12 16480618 1496052 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Negative_regulation TNF MAPK12 16480618 1496091 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Negative_regulation TNF MAPK12 16581537 1543723 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Negative_regulation TNF MAPK12 16946004 1639280 Finally , the blocking of p44/42 activation *prevented* [TNFalpha] inhibition of FSH dependent increases in P450AROM and inhibin alpha-subunit mRNA levels , thus indicating that p44/42 MAPK mediated ICER expression may be accountable for the effects of TNFalpha on the expression of both proteins . Negative_regulation TNF MAPK12 18246004 1839561 Blocking cytokine activation of p38 *reduced* IL-1 and [TNF-alpha] induced PGE2 and IL-6 accumulation . Negative_regulation TNF MAPK12 18559343 1952540 OxPAPC inhibited [tumor necrosis factor-alpha] production , IkappaBalpha degradation , p38 phosphorylation , and NF-kappaB dependent reporter activation *induced* by stimulants of TLR2 and TLR4 ( Pam3CSK4 and LPS ) but not by stimulants of other TLRs ( poly ( I.C ) , flagellin , loxoribine , single stranded RNA , or CpG DNA ) in macrophages and HEK-293 cells transfected with respective TLRs and significantly reduced inflammatory responses in mice injected subcutaneously or intraperitoneally with Pam3CSK4 . Negative_regulation TNF MAPK12 18675993 2011217 The role of P38 and PKC in BLP *induced* [TNF-alpha] release , apoptosis , and NFkappaB activation in THP-1 monocyte cells . Negative_regulation TNF MAPK12 18675993 2011301 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Negative_regulation TNF MAPK12 19052649 1999770 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Negative_regulation TNF MAPK12 19086324 2000258 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 and NF-kappaB activities , and then [TNF-alpha] overexpression , thus alleviating the inflammatory reaction . Negative_regulation TNF MAPK12 19118509 2004782 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and [TNF-alpha] and *inhibited* the phosphorylation of Akt , PKCdelta and p38 . Negative_regulation TNF MAPK12 19450605 2096898 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 and *inhibited* cardiac [TNF-alpha] expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation TNF MAPK12 19493203 2091411 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Negative_regulation TNF MAPK12 21147093 2378243 LPS induced phosphorylation of I?Ba and p38 was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and [TNF-a] production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation TNF MAPK12 21208554 2374403 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Negative_regulation TNF MAPK12 23056531 2685369 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit [tumor necrosis factor] a ( TNF-a production in cultured macrophages ) and in vitro p38a *inhibition* . Negative_regulation TNF MAPK12 23518420 2777186 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and [TNF-a] protein expression in the kidney , as well as *inhibiting* signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation TNF MAPK12 24152910 2875217 It was found that thrombin down-regulates the HMGB1 mediated induction of both [TNF-a] and IL-6 and *inhibits* the activation of both p38 and NF-?B in HUVECs pretreated with PC . Negative_regulation TNF MAPK12 24997655 2952767 We conclude that exposure to PRL *increases* [TNF-a] release from CD14 ( + ) monocytes of RA patients , which can be abolished by PRLR gene silencing or treating with inhibitor . Negative_regulation TNF MAPK12 9418855 480513 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Negative_regulation TNF MAPK12 9439626 482855 Tyrosine kinase and *inhibition* of [TNF-alpha-] and EGF stimulated IEC-6 cell growth . Negative_regulation TNF MAPK12 9864164 582629 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Negative_regulation TNF MAPK13 10079106 595550 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Negative_regulation TNF MAPK13 10620700 657630 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Negative_regulation TNF MAPK13 10655266 663498 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Negative_regulation TNF MAPK13 10657669 664176 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Negative_regulation TNF MAPK13 10783388 707809 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Negative_regulation TNF MAPK13 11299196 803152 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Negative_regulation TNF MAPK13 11299196 803218 SB203580 inhibited p38 activity , *reduced* myocyte secretion of [TNF-alpha] , and prevented burn mediated cardiac deficits . Negative_regulation TNF MAPK13 11699878 878364 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Negative_regulation TNF MAPK13 11715476 581258 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Negative_regulation TNF MAPK13 11815388 907607 These results indicate that the MAPK pathway and *mediated* regulation of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Negative_regulation TNF MAPK13 12485415 1032941 CRH effects on [TNF-alpha] release were also *inhibited* by specific inhibitors of MEK , the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 ( SB203580 ) , but not by H89 . Negative_regulation TNF MAPK13 12506117 1056914 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Negative_regulation TNF MAPK13 12559181 1052104 It was concluded that pretranscriptional regulation of [TNF] gene expression in Kupffer cells *follows* an orderly activation of , ERK1/2 , and SAPK/JNK that may not converge on NF-kappaB . Negative_regulation TNF MAPK13 12760489 895614 However , a specific inhibitor of p38 , SB203580 , *had* no effect on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Negative_regulation TNF MAPK13 15519192 1328823 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial [TNFalpha] mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as TNFalpha production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 activation . Negative_regulation TNF MAPK13 15557189 1340397 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Negative_regulation TNF MAPK13 16480618 1496053 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Negative_regulation TNF MAPK13 16480618 1496092 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Negative_regulation TNF MAPK13 16581537 1543724 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Negative_regulation TNF MAPK13 16946004 1639281 Finally , the blocking of p44/42 activation *prevented* [TNFalpha] inhibition of FSH dependent increases in P450AROM and inhibin alpha-subunit mRNA levels , thus indicating that p44/42 MAPK mediated ICER expression may be accountable for the effects of TNFalpha on the expression of both proteins . Negative_regulation TNF MAPK13 18246004 1839562 Blocking cytokine activation of p38 *reduced* IL-1 and [TNF-alpha] induced PGE2 and IL-6 accumulation . Negative_regulation TNF MAPK13 18559343 1952541 OxPAPC inhibited [tumor necrosis factor-alpha] production , IkappaBalpha degradation , p38 phosphorylation , and NF-kappaB dependent reporter activation *induced* by stimulants of TLR2 and TLR4 ( Pam3CSK4 and LPS ) but not by stimulants of other TLRs ( poly ( I.C ) , flagellin , loxoribine , single stranded RNA , or CpG DNA ) in macrophages and HEK-293 cells transfected with respective TLRs and significantly reduced inflammatory responses in mice injected subcutaneously or intraperitoneally with Pam3CSK4 . Negative_regulation TNF MAPK13 18675993 2011218 The role of P38 and PKC in BLP *induced* [TNF-alpha] release , apoptosis , and NFkappaB activation in THP-1 monocyte cells . Negative_regulation TNF MAPK13 18675993 2011302 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Negative_regulation TNF MAPK13 19052649 1999771 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Negative_regulation TNF MAPK13 19086324 2000259 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 and NF-kappaB activities , and then [TNF-alpha] overexpression , thus alleviating the inflammatory reaction . Negative_regulation TNF MAPK13 19118509 2004783 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and [TNF-alpha] and *inhibited* the phosphorylation of Akt , PKCdelta and p38 . Negative_regulation TNF MAPK13 19450605 2096899 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 and *inhibited* cardiac [TNF-alpha] expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation TNF MAPK13 19493203 2091412 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Negative_regulation TNF MAPK13 21147093 2378244 LPS induced phosphorylation of I?Ba and p38 was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and [TNF-a] production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation TNF MAPK13 21208554 2374404 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Negative_regulation TNF MAPK13 23056531 2685370 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit [tumor necrosis factor] a ( TNF-a production in cultured macrophages ) and in vitro p38a *inhibition* . Negative_regulation TNF MAPK13 23518420 2777187 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and [TNF-a] protein expression in the kidney , as well as *inhibiting* signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation TNF MAPK13 24152910 2875218 It was found that thrombin down-regulates the HMGB1 mediated induction of both [TNF-a] and IL-6 and *inhibits* the activation of both p38 and NF-?B in HUVECs pretreated with PC . Negative_regulation TNF MAPK13 24997655 2952768 We conclude that exposure to PRL *increases* [TNF-a] release from CD14 ( + ) monocytes of RA patients , which can be abolished by PRLR gene silencing or treating with inhibitor . Negative_regulation TNF MAPK13 9418855 480514 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Negative_regulation TNF MAPK13 9439626 482856 Tyrosine kinase and *inhibition* of [TNF-alpha-] and EGF stimulated IEC-6 cell growth . Negative_regulation TNF MAPK13 9864164 582630 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Negative_regulation TNF MAPK14 10079106 595551 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Negative_regulation TNF MAPK14 10620700 657631 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Negative_regulation TNF MAPK14 10655266 663499 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Negative_regulation TNF MAPK14 10657669 664177 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Negative_regulation TNF MAPK14 10783388 707810 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Negative_regulation TNF MAPK14 11299196 803153 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Negative_regulation TNF MAPK14 11299196 803219 SB203580 inhibited p38 activity , *reduced* myocyte secretion of [TNF-alpha] , and prevented burn mediated cardiac deficits . Negative_regulation TNF MAPK14 11699878 878365 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Negative_regulation TNF MAPK14 11715476 581259 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Negative_regulation TNF MAPK14 11815388 907608 These results indicate that the MAPK pathway and *mediated* regulation of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Negative_regulation TNF MAPK14 12485415 1032942 CRH effects on [TNF-alpha] release were also *inhibited* by specific inhibitors of MEK , the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 ( SB203580 ) , but not by H89 . Negative_regulation TNF MAPK14 12506117 1056915 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Negative_regulation TNF MAPK14 12559181 1052105 It was concluded that pretranscriptional regulation of [TNF] gene expression in Kupffer cells *follows* an orderly activation of , ERK1/2 , and SAPK/JNK that may not converge on NF-kappaB . Negative_regulation TNF MAPK14 12760489 895615 However , a specific inhibitor of p38 , SB203580 , *had* no effect on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Negative_regulation TNF MAPK14 15519192 1328824 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial TNFalpha mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as [TNFalpha] production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 activation . Negative_regulation TNF MAPK14 15557189 1340398 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Negative_regulation TNF MAPK14 16480618 1496054 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Negative_regulation TNF MAPK14 16480618 1496093 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Negative_regulation TNF MAPK14 16581537 1543725 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Negative_regulation TNF MAPK14 16946004 1639282 Finally , the blocking of p44/42 activation *prevented* [TNFalpha] inhibition of FSH dependent increases in P450AROM and inhibin alpha-subunit mRNA levels , thus indicating that p44/42 MAPK mediated ICER expression may be accountable for the effects of TNFalpha on the expression of both proteins . Negative_regulation TNF MAPK14 18246004 1839563 Blocking cytokine activation of p38 *reduced* IL-1 and [TNF-alpha] induced PGE2 and IL-6 accumulation . Negative_regulation TNF MAPK14 18559343 1952542 OxPAPC inhibited [tumor necrosis factor-alpha] production , IkappaBalpha degradation , p38 phosphorylation , and NF-kappaB dependent reporter activation *induced* by stimulants of TLR2 and TLR4 ( Pam3CSK4 and LPS ) but not by stimulants of other TLRs ( poly ( I.C ) , flagellin , loxoribine , single stranded RNA , or CpG DNA ) in macrophages and HEK-293 cells transfected with respective TLRs and significantly reduced inflammatory responses in mice injected subcutaneously or intraperitoneally with Pam3CSK4 . Negative_regulation TNF MAPK14 18675993 2011219 The role of P38 and PKC in BLP *induced* [TNF-alpha] release , apoptosis , and NFkappaB activation in THP-1 monocyte cells . Negative_regulation TNF MAPK14 18675993 2011303 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Negative_regulation TNF MAPK14 19052649 1999772 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Negative_regulation TNF MAPK14 19086324 2000260 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 and NF-kappaB activities , and then [TNF-alpha] overexpression , thus alleviating the inflammatory reaction . Negative_regulation TNF MAPK14 19118509 2004784 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and [TNF-alpha] and *inhibited* the phosphorylation of Akt , PKCdelta and p38 . Negative_regulation TNF MAPK14 19450605 2096900 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 and *inhibited* cardiac [TNF-alpha] expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation TNF MAPK14 19493203 2091413 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Negative_regulation TNF MAPK14 21147093 2378245 LPS induced phosphorylation of I?Ba and p38 was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and [TNF-a] production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation TNF MAPK14 21208554 2374405 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Negative_regulation TNF MAPK14 23056531 2685371 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit [tumor necrosis factor] a ( TNF-a production in cultured macrophages ) and in vitro p38a *inhibition* . Negative_regulation TNF MAPK14 23518420 2777188 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and [TNF-a] protein expression in the kidney , as well as *inhibiting* signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation TNF MAPK14 24152910 2875219 It was found that thrombin down-regulates the HMGB1 mediated induction of both [TNF-a] and IL-6 and *inhibits* the activation of both p38 and NF-?B in HUVECs pretreated with PC . Negative_regulation TNF MAPK14 24997655 2952769 We conclude that exposure to PRL *increases* [TNF-a] release from CD14 ( + ) monocytes of RA patients , which can be abolished by PRLR gene silencing or treating with inhibitor . Negative_regulation TNF MAPK14 9418855 480515 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Negative_regulation TNF MAPK14 9439626 482857 Tyrosine kinase and *inhibition* of [TNF-alpha-] and EGF stimulated IEC-6 cell growth . Negative_regulation TNF MAPK14 9864164 582631 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Negative_regulation TNF MAPK15 10079106 595545 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Negative_regulation TNF MAPK15 10620700 657625 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Negative_regulation TNF MAPK15 10655266 663492 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Negative_regulation TNF MAPK15 10657669 664171 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Negative_regulation TNF MAPK15 10783388 707804 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Negative_regulation TNF MAPK15 11299196 803147 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Negative_regulation TNF MAPK15 11299196 803212 SB203580 inhibited p38 activity , *reduced* myocyte secretion of [TNF-alpha] , and prevented burn mediated cardiac deficits . Negative_regulation TNF MAPK15 11699878 878359 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Negative_regulation TNF MAPK15 11715476 581253 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Negative_regulation TNF MAPK15 11815388 907602 These results indicate that the MAPK pathway and *mediated* regulation of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Negative_regulation TNF MAPK15 12485415 1032929 CRH effects on [TNF-alpha] release were also *inhibited* by specific inhibitors of MEK , the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 ( SB203580 ) , but not by H89 . Negative_regulation TNF MAPK15 12506117 1056909 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Negative_regulation TNF MAPK15 12559181 1052098 It was concluded that pretranscriptional regulation of [TNF] gene expression in Kupffer cells *follows* an orderly activation of , ERK1/2 , and SAPK/JNK that may not converge on NF-kappaB . Negative_regulation TNF MAPK15 12760489 895609 However , a specific inhibitor of p38 , SB203580 , *had* no effect on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Negative_regulation TNF MAPK15 15519192 1328817 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial [TNFalpha] mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as TNFalpha production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 activation . Negative_regulation TNF MAPK15 15557189 1340392 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Negative_regulation TNF MAPK15 16480618 1496048 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Negative_regulation TNF MAPK15 16480618 1496087 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Negative_regulation TNF MAPK15 16581537 1543719 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Negative_regulation TNF MAPK15 16946004 1639276 Finally , the blocking of p44/42 activation *prevented* [TNFalpha] inhibition of FSH dependent increases in P450AROM and inhibin alpha-subunit mRNA levels , thus indicating that p44/42 MAPK mediated ICER expression may be accountable for the effects of TNFalpha on the expression of both proteins . Negative_regulation TNF MAPK15 18246004 1839557 Blocking cytokine activation of p38 *reduced* IL-1 and [TNF-alpha] induced PGE2 and IL-6 accumulation . Negative_regulation TNF MAPK15 18559343 1952535 OxPAPC inhibited [tumor necrosis factor-alpha] production , IkappaBalpha degradation , p38 phosphorylation , and NF-kappaB dependent reporter activation *induced* by stimulants of TLR2 and TLR4 ( Pam3CSK4 and LPS ) but not by stimulants of other TLRs ( poly ( I.C ) , flagellin , loxoribine , single stranded RNA , or CpG DNA ) in macrophages and HEK-293 cells transfected with respective TLRs and significantly reduced inflammatory responses in mice injected subcutaneously or intraperitoneally with Pam3CSK4 . Negative_regulation TNF MAPK15 18675993 2011213 The role of P38 and PKC in BLP *induced* [TNF-alpha] release , apoptosis , and NFkappaB activation in THP-1 monocyte cells . Negative_regulation TNF MAPK15 18675993 2011297 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Negative_regulation TNF MAPK15 19052649 1999766 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Negative_regulation TNF MAPK15 19086324 2000254 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 and NF-kappaB activities , and then [TNF-alpha] overexpression , thus alleviating the inflammatory reaction . Negative_regulation TNF MAPK15 19118509 2004775 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and [TNF-alpha] and *inhibited* the phosphorylation of Akt , PKCdelta and p38 . Negative_regulation TNF MAPK15 19450605 2096893 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 and *inhibited* cardiac [TNF-alpha] expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation TNF MAPK15 19493203 2091407 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Negative_regulation TNF MAPK15 21147093 2378239 LPS induced phosphorylation of I?Ba and p38 was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and [TNF-a] production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation TNF MAPK15 21208554 2374399 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Negative_regulation TNF MAPK15 23056531 2685365 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit [tumor necrosis factor] a ( TNF-a production in cultured macrophages ) and in vitro p38a *inhibition* . Negative_regulation TNF MAPK15 23518420 2777182 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and [TNF-a] protein expression in the kidney , as well as *inhibiting* signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation TNF MAPK15 24152910 2875213 It was found that thrombin down-regulates the HMGB1 mediated induction of both [TNF-a] and IL-6 and *inhibits* the activation of both p38 and NF-?B in HUVECs pretreated with PC . Negative_regulation TNF MAPK15 24997655 2952763 We conclude that exposure to PRL *increases* [TNF-a] release from CD14 ( + ) monocytes of RA patients , which can be abolished by PRLR gene silencing or treating with inhibitor . Negative_regulation TNF MAPK15 9418855 480509 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Negative_regulation TNF MAPK15 9439626 482851 Tyrosine kinase and *inhibition* of [TNF-alpha-] and EGF stimulated IEC-6 cell growth . Negative_regulation TNF MAPK15 9864164 582625 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Negative_regulation TNF MAPK3 10079106 595552 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Negative_regulation TNF MAPK3 10620700 657632 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Negative_regulation TNF MAPK3 10655266 663500 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Negative_regulation TNF MAPK3 10657669 664178 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Negative_regulation TNF MAPK3 10783388 707811 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Negative_regulation TNF MAPK3 11299196 803154 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Negative_regulation TNF MAPK3 11299196 803220 SB203580 inhibited p38 activity , *reduced* myocyte secretion of [TNF-alpha] , and prevented burn mediated cardiac deficits . Negative_regulation TNF MAPK3 11699878 878366 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Negative_regulation TNF MAPK3 11715476 581260 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Negative_regulation TNF MAPK3 11815388 907609 These results indicate that the MAPK pathway and *mediated* regulation of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Negative_regulation TNF MAPK3 11997234 939274 However , the *role* of activation in mediating LPS stimulated [TNF-alpha] production is not well understood . Negative_regulation TNF MAPK3 12485415 1032943 CRH effects on [TNF-alpha] release were also *inhibited* by specific inhibitors of MEK , the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 ( SB203580 ) , but not by H89 . Negative_regulation TNF MAPK3 12506117 1056916 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Negative_regulation TNF MAPK3 12559181 1052106 It was concluded that pretranscriptional regulation of [TNF] gene expression in Kupffer cells *follows* an orderly activation of p38-MAPK , , and SAPK/JNK that may not converge on NF-kappaB . Negative_regulation TNF MAPK3 12760489 895616 However , a specific inhibitor of p38 , SB203580 , *had* no effect on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Negative_regulation TNF MAPK3 15519192 1328825 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial [TNFalpha] mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as TNFalpha production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 activation . Negative_regulation TNF MAPK3 15557189 1340399 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Negative_regulation TNF MAPK3 16480618 1496055 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Negative_regulation TNF MAPK3 16480618 1496094 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Negative_regulation TNF MAPK3 16581537 1543726 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Negative_regulation TNF MAPK3 16946004 1639283 Finally , the blocking of p44/42 activation *prevented* [TNFalpha] inhibition of FSH dependent increases in P450AROM and inhibin alpha-subunit mRNA levels , thus indicating that p44/42 MAPK mediated ICER expression may be accountable for the effects of TNFalpha on the expression of both proteins . Negative_regulation TNF MAPK3 18246004 1839564 Blocking cytokine activation of p38 *reduced* IL-1 and [TNF-alpha] induced PGE2 and IL-6 accumulation . Negative_regulation TNF MAPK3 18559343 1952543 OxPAPC inhibited [tumor necrosis factor-alpha] production , IkappaBalpha degradation , p38 phosphorylation , and NF-kappaB dependent reporter activation *induced* by stimulants of TLR2 and TLR4 ( Pam3CSK4 and LPS ) but not by stimulants of other TLRs ( poly ( I.C ) , flagellin , loxoribine , single stranded RNA , or CpG DNA ) in macrophages and HEK-293 cells transfected with respective TLRs and significantly reduced inflammatory responses in mice injected subcutaneously or intraperitoneally with Pam3CSK4 . Negative_regulation TNF MAPK3 18675993 2011220 The role of P38 and PKC in BLP *induced* [TNF-alpha] release , apoptosis , and NFkappaB activation in THP-1 monocyte cells . Negative_regulation TNF MAPK3 18675993 2011304 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Negative_regulation TNF MAPK3 19052649 1999773 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Negative_regulation TNF MAPK3 19086324 2000261 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 and NF-kappaB activities , and then [TNF-alpha] overexpression , thus alleviating the inflammatory reaction . Negative_regulation TNF MAPK3 19118509 2004785 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and [TNF-alpha] and *inhibited* the phosphorylation of Akt , PKCdelta and p38 . Negative_regulation TNF MAPK3 19155305 2032347 Signaling via GITRL into patient AML cells induced the release of [TNF] and interleukin-10 (IL-10) , and this was *blocked* by the inhibition of mitogen activated protein kinases . Negative_regulation TNF MAPK3 19450605 2096901 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 and *inhibited* cardiac [TNF-alpha] expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation TNF MAPK3 19493203 2091414 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Negative_regulation TNF MAPK3 21147093 2378246 LPS induced phosphorylation of I?Ba and p38 was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and [TNF-a] production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation TNF MAPK3 21208554 2374406 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Negative_regulation TNF MAPK3 21925494 2492120 The drug also reduced M. leprae induced [TNF-a] production and *inhibited* p38 and activation . Negative_regulation TNF MAPK3 22198506 2558714 MKP1 attenuates and p38 activation , *inhibits* myocardial [TNF-a] expression , and improves cardiac function in endotoxemia . Negative_regulation TNF MAPK3 23056531 2685372 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit [tumor necrosis factor] a ( TNF-a production in cultured macrophages ) and in vitro p38a *inhibition* . Negative_regulation TNF MAPK3 23518420 2777189 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and [TNF-a] protein expression in the kidney , as well as *inhibiting* signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation TNF MAPK3 24152910 2875220 It was found that thrombin down-regulates the HMGB1 mediated induction of both [TNF-a] and IL-6 and *inhibits* the activation of both p38 and NF-?B in HUVECs pretreated with PC . Negative_regulation TNF MAPK3 24997655 2952770 We conclude that exposure to PRL *increases* [TNF-a] release from CD14 ( + ) monocytes of RA patients , which can be abolished by PRLR gene silencing or treating with inhibitor . Negative_regulation TNF MAPK3 9418855 480516 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Negative_regulation TNF MAPK3 9439626 482858 Tyrosine kinase and *inhibition* of [TNF-alpha-] and EGF stimulated IEC-6 cell growth . Negative_regulation TNF MAPK3 9864164 582632 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Negative_regulation TNF MAPK4 10079106 595553 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Negative_regulation TNF MAPK4 10620700 657633 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Negative_regulation TNF MAPK4 10655266 663501 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Negative_regulation TNF MAPK4 10657669 664179 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Negative_regulation TNF MAPK4 10783388 707812 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Negative_regulation TNF MAPK4 11299196 803155 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Negative_regulation TNF MAPK4 11299196 803221 SB203580 inhibited p38 activity , *reduced* myocyte secretion of [TNF-alpha] , and prevented burn mediated cardiac deficits . Negative_regulation TNF MAPK4 11699878 878367 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Negative_regulation TNF MAPK4 11715476 581261 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Negative_regulation TNF MAPK4 11815388 907610 These results indicate that the MAPK pathway and *mediated* regulation of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Negative_regulation TNF MAPK4 12485415 1032944 CRH effects on [TNF-alpha] release were also *inhibited* by specific inhibitors of MEK , the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 ( SB203580 ) , but not by H89 . Negative_regulation TNF MAPK4 12506117 1056917 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Negative_regulation TNF MAPK4 12559181 1052107 It was concluded that pretranscriptional regulation of [TNF] gene expression in Kupffer cells *follows* an orderly activation of , ERK1/2 , and SAPK/JNK that may not converge on NF-kappaB . Negative_regulation TNF MAPK4 12760489 895617 However , a specific inhibitor of p38 , SB203580 , *had* no effect on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Negative_regulation TNF MAPK4 15519192 1328826 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial TNFalpha mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as [TNFalpha] production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 activation . Negative_regulation TNF MAPK4 15557189 1340400 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Negative_regulation TNF MAPK4 16480618 1496056 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Negative_regulation TNF MAPK4 16480618 1496095 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Negative_regulation TNF MAPK4 16581537 1543727 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Negative_regulation TNF MAPK4 16946004 1639284 Finally , the blocking of p44/42 activation *prevented* [TNFalpha] inhibition of FSH dependent increases in P450AROM and inhibin alpha-subunit mRNA levels , thus indicating that p44/42 MAPK mediated ICER expression may be accountable for the effects of TNFalpha on the expression of both proteins . Negative_regulation TNF MAPK4 18246004 1839565 Blocking cytokine activation of p38 *reduced* IL-1 and [TNF-alpha] induced PGE2 and IL-6 accumulation . Negative_regulation TNF MAPK4 18559343 1952544 OxPAPC inhibited [tumor necrosis factor-alpha] production , IkappaBalpha degradation , p38 phosphorylation , and NF-kappaB dependent reporter activation *induced* by stimulants of TLR2 and TLR4 ( Pam3CSK4 and LPS ) but not by stimulants of other TLRs ( poly ( I.C ) , flagellin , loxoribine , single stranded RNA , or CpG DNA ) in macrophages and HEK-293 cells transfected with respective TLRs and significantly reduced inflammatory responses in mice injected subcutaneously or intraperitoneally with Pam3CSK4 . Negative_regulation TNF MAPK4 18675993 2011221 The role of P38 and PKC in BLP *induced* [TNF-alpha] release , apoptosis , and NFkappaB activation in THP-1 monocyte cells . Negative_regulation TNF MAPK4 18675993 2011305 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Negative_regulation TNF MAPK4 19052649 1999774 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Negative_regulation TNF MAPK4 19086324 2000262 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 and NF-kappaB activities , and then [TNF-alpha] overexpression , thus alleviating the inflammatory reaction . Negative_regulation TNF MAPK4 19118509 2004786 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and [TNF-alpha] and *inhibited* the phosphorylation of Akt , PKCdelta and p38 . Negative_regulation TNF MAPK4 19450605 2096902 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 and *inhibited* cardiac [TNF-alpha] expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation TNF MAPK4 19493203 2091415 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Negative_regulation TNF MAPK4 21147093 2378247 LPS induced phosphorylation of I?Ba and p38 was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and [TNF-a] production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation TNF MAPK4 21208554 2374407 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Negative_regulation TNF MAPK4 23056531 2685373 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit [tumor necrosis factor] a ( TNF-a production in cultured macrophages ) and in vitro p38a *inhibition* . Negative_regulation TNF MAPK4 23518420 2777190 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and [TNF-a] protein expression in the kidney , as well as *inhibiting* signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation TNF MAPK4 24152910 2875221 It was found that thrombin down-regulates the HMGB1 mediated induction of both [TNF-a] and IL-6 and *inhibits* the activation of both p38 and NF-?B in HUVECs pretreated with PC . Negative_regulation TNF MAPK4 24997655 2952771 We conclude that exposure to PRL *increases* [TNF-a] release from CD14 ( + ) monocytes of RA patients , which can be abolished by PRLR gene silencing or treating with inhibitor . Negative_regulation TNF MAPK4 9418855 480517 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Negative_regulation TNF MAPK4 9439626 482859 Tyrosine kinase and *inhibition* of [TNF-alpha-] and EGF stimulated IEC-6 cell growth . Negative_regulation TNF MAPK4 9864164 582633 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Negative_regulation TNF MAPK6 10079106 595554 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Negative_regulation TNF MAPK6 10620700 657634 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Negative_regulation TNF MAPK6 10655266 663502 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Negative_regulation TNF MAPK6 10657669 664180 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Negative_regulation TNF MAPK6 10783388 707813 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Negative_regulation TNF MAPK6 11299196 803156 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Negative_regulation TNF MAPK6 11299196 803222 SB203580 inhibited p38 activity , *reduced* myocyte secretion of [TNF-alpha] , and prevented burn mediated cardiac deficits . Negative_regulation TNF MAPK6 11699878 878368 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Negative_regulation TNF MAPK6 11715476 581262 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Negative_regulation TNF MAPK6 11815388 907611 These results indicate that the MAPK pathway and *mediated* regulation of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Negative_regulation TNF MAPK6 12485415 1032945 CRH effects on [TNF-alpha] release were also *inhibited* by specific inhibitors of MEK , the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 ( SB203580 ) , but not by H89 . Negative_regulation TNF MAPK6 12506117 1056918 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Negative_regulation TNF MAPK6 12559181 1052108 It was concluded that pretranscriptional regulation of [TNF] gene expression in Kupffer cells *follows* an orderly activation of , ERK1/2 , and SAPK/JNK that may not converge on NF-kappaB . Negative_regulation TNF MAPK6 12760489 895618 However , a specific inhibitor of p38 , SB203580 , *had* no effect on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Negative_regulation TNF MAPK6 15519192 1328827 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial [TNFalpha] mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as TNFalpha production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 activation . Negative_regulation TNF MAPK6 15557189 1340401 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Negative_regulation TNF MAPK6 16480618 1496057 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Negative_regulation TNF MAPK6 16480618 1496096 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Negative_regulation TNF MAPK6 16581537 1543728 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Negative_regulation TNF MAPK6 16946004 1639285 Finally , the blocking of p44/42 activation *prevented* [TNFalpha] inhibition of FSH dependent increases in P450AROM and inhibin alpha-subunit mRNA levels , thus indicating that p44/42 MAPK mediated ICER expression may be accountable for the effects of TNFalpha on the expression of both proteins . Negative_regulation TNF MAPK6 18246004 1839566 Blocking cytokine activation of p38 *reduced* IL-1 and [TNF-alpha] induced PGE2 and IL-6 accumulation . Negative_regulation TNF MAPK6 18559343 1952545 OxPAPC inhibited [tumor necrosis factor-alpha] production , IkappaBalpha degradation , p38 phosphorylation , and NF-kappaB dependent reporter activation *induced* by stimulants of TLR2 and TLR4 ( Pam3CSK4 and LPS ) but not by stimulants of other TLRs ( poly ( I.C ) , flagellin , loxoribine , single stranded RNA , or CpG DNA ) in macrophages and HEK-293 cells transfected with respective TLRs and significantly reduced inflammatory responses in mice injected subcutaneously or intraperitoneally with Pam3CSK4 . Negative_regulation TNF MAPK6 18675993 2011222 The role of P38 and PKC in BLP *induced* [TNF-alpha] release , apoptosis , and NFkappaB activation in THP-1 monocyte cells . Negative_regulation TNF MAPK6 18675993 2011306 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Negative_regulation TNF MAPK6 19052649 1999775 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Negative_regulation TNF MAPK6 19086324 2000263 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 and NF-kappaB activities , and then [TNF-alpha] overexpression , thus alleviating the inflammatory reaction . Negative_regulation TNF MAPK6 19118509 2004787 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and [TNF-alpha] and *inhibited* the phosphorylation of Akt , PKCdelta and p38 . Negative_regulation TNF MAPK6 19450605 2096903 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 and *inhibited* cardiac [TNF-alpha] expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation TNF MAPK6 19493203 2091416 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Negative_regulation TNF MAPK6 21147093 2378248 LPS induced phosphorylation of I?Ba and p38 was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and [TNF-a] production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation TNF MAPK6 21208554 2374408 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Negative_regulation TNF MAPK6 23056531 2685374 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit [tumor necrosis factor] a ( TNF-a production in cultured macrophages ) and in vitro p38a *inhibition* . Negative_regulation TNF MAPK6 23518420 2777191 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and [TNF-a] protein expression in the kidney , as well as *inhibiting* signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation TNF MAPK6 24152910 2875222 It was found that thrombin down-regulates the HMGB1 mediated induction of both [TNF-a] and IL-6 and *inhibits* the activation of both p38 and NF-?B in HUVECs pretreated with PC . Negative_regulation TNF MAPK6 24997655 2952772 We conclude that exposure to PRL *increases* [TNF-a] release from CD14 ( + ) monocytes of RA patients , which can be abolished by PRLR gene silencing or treating with inhibitor . Negative_regulation TNF MAPK6 9418855 480518 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Negative_regulation TNF MAPK6 9439626 482860 Tyrosine kinase and *inhibition* of [TNF-alpha-] and EGF stimulated IEC-6 cell growth . Negative_regulation TNF MAPK6 9864164 582634 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Negative_regulation TNF MAPK7 10079106 595555 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Negative_regulation TNF MAPK7 10620700 657635 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Negative_regulation TNF MAPK7 10655266 663503 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Negative_regulation TNF MAPK7 10657669 664181 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Negative_regulation TNF MAPK7 10783388 707814 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Negative_regulation TNF MAPK7 11299196 803157 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Negative_regulation TNF MAPK7 11299196 803223 SB203580 inhibited p38 activity , *reduced* myocyte secretion of [TNF-alpha] , and prevented burn mediated cardiac deficits . Negative_regulation TNF MAPK7 11699878 878369 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Negative_regulation TNF MAPK7 11715476 581263 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Negative_regulation TNF MAPK7 11815388 907612 These results indicate that the MAPK pathway and *mediated* regulation of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Negative_regulation TNF MAPK7 12485415 1032946 CRH effects on [TNF-alpha] release were also *inhibited* by specific inhibitors of MEK , the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 ( SB203580 ) , but not by H89 . Negative_regulation TNF MAPK7 12506117 1056919 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Negative_regulation TNF MAPK7 12559181 1052109 It was concluded that pretranscriptional regulation of [TNF] gene expression in Kupffer cells *follows* an orderly activation of , ERK1/2 , and SAPK/JNK that may not converge on NF-kappaB . Negative_regulation TNF MAPK7 12760489 895619 However , a specific inhibitor of p38 , SB203580 , *had* no effect on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Negative_regulation TNF MAPK7 15519192 1328828 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial TNFalpha mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as [TNFalpha] production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 activation . Negative_regulation TNF MAPK7 15557189 1340402 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Negative_regulation TNF MAPK7 16480618 1496058 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Negative_regulation TNF MAPK7 16480618 1496097 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Negative_regulation TNF MAPK7 16581537 1543729 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Negative_regulation TNF MAPK7 16946004 1639286 Finally , the blocking of p44/42 activation *prevented* [TNFalpha] inhibition of FSH dependent increases in P450AROM and inhibin alpha-subunit mRNA levels , thus indicating that p44/42 MAPK mediated ICER expression may be accountable for the effects of TNFalpha on the expression of both proteins . Negative_regulation TNF MAPK7 18246004 1839567 Blocking cytokine activation of p38 *reduced* IL-1 and [TNF-alpha] induced PGE2 and IL-6 accumulation . Negative_regulation TNF MAPK7 18559343 1952546 OxPAPC inhibited [tumor necrosis factor-alpha] production , IkappaBalpha degradation , p38 phosphorylation , and NF-kappaB dependent reporter activation *induced* by stimulants of TLR2 and TLR4 ( Pam3CSK4 and LPS ) but not by stimulants of other TLRs ( poly ( I.C ) , flagellin , loxoribine , single stranded RNA , or CpG DNA ) in macrophages and HEK-293 cells transfected with respective TLRs and significantly reduced inflammatory responses in mice injected subcutaneously or intraperitoneally with Pam3CSK4 . Negative_regulation TNF MAPK7 18675993 2011223 The role of P38 and PKC in BLP *induced* [TNF-alpha] release , apoptosis , and NFkappaB activation in THP-1 monocyte cells . Negative_regulation TNF MAPK7 18675993 2011307 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Negative_regulation TNF MAPK7 19052649 1999776 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Negative_regulation TNF MAPK7 19086324 2000264 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 and NF-kappaB activities , and then [TNF-alpha] overexpression , thus alleviating the inflammatory reaction . Negative_regulation TNF MAPK7 19118509 2004788 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and [TNF-alpha] and *inhibited* the phosphorylation of Akt , PKCdelta and p38 . Negative_regulation TNF MAPK7 19450605 2096904 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 and *inhibited* cardiac [TNF-alpha] expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation TNF MAPK7 19493203 2091417 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Negative_regulation TNF MAPK7 21147093 2378249 LPS induced phosphorylation of I?Ba and p38 was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and [TNF-a] production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation TNF MAPK7 21208554 2374409 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Negative_regulation TNF MAPK7 23056531 2685375 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit [tumor necrosis factor] a ( TNF-a production in cultured macrophages ) and in vitro p38a *inhibition* . Negative_regulation TNF MAPK7 23518420 2777192 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and [TNF-a] protein expression in the kidney , as well as *inhibiting* signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation TNF MAPK7 24152910 2875223 It was found that thrombin down-regulates the HMGB1 mediated induction of both [TNF-a] and IL-6 and *inhibits* the activation of both p38 and NF-?B in HUVECs pretreated with PC . Negative_regulation TNF MAPK7 24997655 2952773 We conclude that exposure to PRL *increases* [TNF-a] release from CD14 ( + ) monocytes of RA patients , which can be abolished by PRLR gene silencing or treating with inhibitor . Negative_regulation TNF MAPK7 9418855 480519 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Negative_regulation TNF MAPK7 9439626 482861 Tyrosine kinase and *inhibition* of [TNF-alpha-] and EGF stimulated IEC-6 cell growth . Negative_regulation TNF MAPK7 9864164 582635 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Negative_regulation TNF MAPK8 10079106 595556 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Negative_regulation TNF MAPK8 10620700 657636 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Negative_regulation TNF MAPK8 10655266 663504 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Negative_regulation TNF MAPK8 10657669 664182 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Negative_regulation TNF MAPK8 10783388 707815 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Negative_regulation TNF MAPK8 11299196 803158 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Negative_regulation TNF MAPK8 11299196 803224 SB203580 inhibited p38 activity , *reduced* myocyte secretion of [TNF-alpha] , and prevented burn mediated cardiac deficits . Negative_regulation TNF MAPK8 11699878 878370 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Negative_regulation TNF MAPK8 11715476 581264 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Negative_regulation TNF MAPK8 11815388 907613 These results indicate that the MAPK pathway and *mediated* regulation of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Negative_regulation TNF MAPK8 12485415 1032947 CRH effects on [TNF-alpha] release were also *inhibited* by specific inhibitors of MEK , the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 ( SB203580 ) , but not by H89 . Negative_regulation TNF MAPK8 12506117 1056920 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Negative_regulation TNF MAPK8 12559181 1052110 It was concluded that pretranscriptional regulation of [TNF] gene expression in Kupffer cells *follows* an orderly activation of , ERK1/2 , and SAPK/JNK that may not converge on NF-kappaB . Negative_regulation TNF MAPK8 12760489 895620 However , a specific inhibitor of p38 , SB203580 , *had* no effect on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Negative_regulation TNF MAPK8 15519192 1328829 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial [TNFalpha] mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as TNFalpha production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 activation . Negative_regulation TNF MAPK8 15557189 1340403 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Negative_regulation TNF MAPK8 16480618 1496059 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Negative_regulation TNF MAPK8 16480618 1496098 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Negative_regulation TNF MAPK8 16581537 1543730 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Negative_regulation TNF MAPK8 16946004 1639287 Finally , the blocking of p44/42 activation *prevented* [TNFalpha] inhibition of FSH dependent increases in P450AROM and inhibin alpha-subunit mRNA levels , thus indicating that p44/42 MAPK mediated ICER expression may be accountable for the effects of TNFalpha on the expression of both proteins . Negative_regulation TNF MAPK8 18246004 1839568 Blocking cytokine activation of p38 *reduced* IL-1 and [TNF-alpha] induced PGE2 and IL-6 accumulation . Negative_regulation TNF MAPK8 18559343 1952547 OxPAPC inhibited [tumor necrosis factor-alpha] production , IkappaBalpha degradation , p38 phosphorylation , and NF-kappaB dependent reporter activation *induced* by stimulants of TLR2 and TLR4 ( Pam3CSK4 and LPS ) but not by stimulants of other TLRs ( poly ( I.C ) , flagellin , loxoribine , single stranded RNA , or CpG DNA ) in macrophages and HEK-293 cells transfected with respective TLRs and significantly reduced inflammatory responses in mice injected subcutaneously or intraperitoneally with Pam3CSK4 . Negative_regulation TNF MAPK8 18675993 2011224 The role of P38 and PKC in BLP *induced* [TNF-alpha] release , apoptosis , and NFkappaB activation in THP-1 monocyte cells . Negative_regulation TNF MAPK8 18675993 2011308 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Negative_regulation TNF MAPK8 19043087 2035341 *inhibits* cardiomyocyte [TNF-alpha] expression via a negative crosstalk with ERK and p38 MAPK in endotoxaemia . Negative_regulation TNF MAPK8 19052649 1999777 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Negative_regulation TNF MAPK8 19086324 2000265 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 and NF-kappaB activities , and then [TNF-alpha] overexpression , thus alleviating the inflammatory reaction . Negative_regulation TNF MAPK8 19118509 2004789 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and [TNF-alpha] and *inhibited* the phosphorylation of Akt , PKCdelta and p38 . Negative_regulation TNF MAPK8 19450605 2096905 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 and *inhibited* cardiac [TNF-alpha] expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation TNF MAPK8 19493203 2091418 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Negative_regulation TNF MAPK8 21147093 2378250 LPS induced phosphorylation of I?Ba and p38 was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and [TNF-a] production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation TNF MAPK8 21208554 2374410 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Negative_regulation TNF MAPK8 23056531 2685376 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit [tumor necrosis factor] a ( TNF-a production in cultured macrophages ) and in vitro p38a *inhibition* . Negative_regulation TNF MAPK8 23518420 2777193 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and [TNF-a] protein expression in the kidney , as well as *inhibiting* signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation TNF MAPK8 24152910 2875224 It was found that thrombin down-regulates the HMGB1 mediated induction of both [TNF-a] and IL-6 and *inhibits* the activation of both p38 and NF-?B in HUVECs pretreated with PC . Negative_regulation TNF MAPK8 24997655 2952774 We conclude that exposure to PRL *increases* [TNF-a] release from CD14 ( + ) monocytes of RA patients , which can be abolished by PRLR gene silencing or treating with inhibitor . Negative_regulation TNF MAPK8 9418855 480520 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Negative_regulation TNF MAPK8 9439626 482862 Tyrosine kinase and *inhibition* of [TNF-alpha-] and EGF stimulated IEC-6 cell growth . Negative_regulation TNF MAPK8 9864164 582636 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Negative_regulation TNF MAPK9 10079106 595557 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Negative_regulation TNF MAPK9 10620700 657637 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Negative_regulation TNF MAPK9 10655266 663505 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Negative_regulation TNF MAPK9 10657669 664183 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Negative_regulation TNF MAPK9 10783388 707816 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Negative_regulation TNF MAPK9 11299196 803159 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Negative_regulation TNF MAPK9 11299196 803225 SB203580 inhibited p38 activity , *reduced* myocyte secretion of [TNF-alpha] , and prevented burn mediated cardiac deficits . Negative_regulation TNF MAPK9 11699878 878371 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Negative_regulation TNF MAPK9 11715476 581265 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Negative_regulation TNF MAPK9 11815388 907614 These results indicate that the MAPK pathway and *mediated* regulation of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Negative_regulation TNF MAPK9 12485415 1032948 CRH effects on [TNF-alpha] release were also *inhibited* by specific inhibitors of MEK , the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 ( SB203580 ) , but not by H89 . Negative_regulation TNF MAPK9 12506117 1056921 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Negative_regulation TNF MAPK9 12559181 1052111 It was concluded that pretranscriptional regulation of [TNF] gene expression in Kupffer cells *follows* an orderly activation of , ERK1/2 , and SAPK/JNK that may not converge on NF-kappaB . Negative_regulation TNF MAPK9 12760489 895621 However , a specific inhibitor of p38 , SB203580 , *had* no effect on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Negative_regulation TNF MAPK9 15519192 1328830 FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial TNFalpha mRNA expression ( 190+/-97 vs. 4805+/-3017 , P=0.024 ) as well as [TNFalpha] production ( 0 vs. 9.6+/-2.5 ng/ml , P < 0.05 ) and also *inhibited* p38 activation . Negative_regulation TNF MAPK9 15557189 1340404 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Negative_regulation TNF MAPK9 16480618 1496060 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Negative_regulation TNF MAPK9 16480618 1496099 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Negative_regulation TNF MAPK9 16581537 1543731 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Negative_regulation TNF MAPK9 16946004 1639288 Finally , the blocking of p44/42 activation *prevented* [TNFalpha] inhibition of FSH dependent increases in P450AROM and inhibin alpha-subunit mRNA levels , thus indicating that p44/42 MAPK mediated ICER expression may be accountable for the effects of TNFalpha on the expression of both proteins . Negative_regulation TNF MAPK9 18246004 1839569 Blocking cytokine activation of p38 *reduced* IL-1 and [TNF-alpha] induced PGE2 and IL-6 accumulation . Negative_regulation TNF MAPK9 18559343 1952548 OxPAPC inhibited [tumor necrosis factor-alpha] production , IkappaBalpha degradation , p38 phosphorylation , and NF-kappaB dependent reporter activation *induced* by stimulants of TLR2 and TLR4 ( Pam3CSK4 and LPS ) but not by stimulants of other TLRs ( poly ( I.C ) , flagellin , loxoribine , single stranded RNA , or CpG DNA ) in macrophages and HEK-293 cells transfected with respective TLRs and significantly reduced inflammatory responses in mice injected subcutaneously or intraperitoneally with Pam3CSK4 . Negative_regulation TNF MAPK9 18675993 2011225 The role of P38 and PKC in BLP *induced* [TNF-alpha] release , apoptosis , and NFkappaB activation in THP-1 monocyte cells . Negative_regulation TNF MAPK9 18675993 2011309 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Negative_regulation TNF MAPK9 19052649 1999778 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Negative_regulation TNF MAPK9 19086324 2000266 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 and NF-kappaB activities , and then [TNF-alpha] overexpression , thus alleviating the inflammatory reaction . Negative_regulation TNF MAPK9 19118509 2004790 Treatment with Gab2 siRNA significantly decreased Gab2 expression , inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine , reduced the production of IL-4 and [TNF-alpha] and *inhibited* the phosphorylation of Akt , PKCdelta and p38 . Negative_regulation TNF MAPK9 19450605 2096906 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 and *inhibited* cardiac [TNF-alpha] expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation TNF MAPK9 19493203 2091419 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Negative_regulation TNF MAPK9 21147093 2378251 LPS induced phosphorylation of I?Ba and p38 was blocked by Biochanin-A and it *inhibited* IL-6 , IL-1ß and [TNF-a] production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation . Negative_regulation TNF MAPK9 21208554 2374411 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Negative_regulation TNF MAPK9 23056531 2685377 All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit [tumor necrosis factor] a ( TNF-a production in cultured macrophages ) and in vitro p38a *inhibition* . Negative_regulation TNF MAPK9 23518420 2777194 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and [TNF-a] protein expression in the kidney , as well as *inhibiting* signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation TNF MAPK9 24152910 2875225 It was found that thrombin down-regulates the HMGB1 mediated induction of both [TNF-a] and IL-6 and *inhibits* the activation of both p38 and NF-?B in HUVECs pretreated with PC . Negative_regulation TNF MAPK9 24997655 2952775 We conclude that exposure to PRL *increases* [TNF-a] release from CD14 ( + ) monocytes of RA patients , which can be abolished by PRLR gene silencing or treating with inhibitor . Negative_regulation TNF MAPK9 9418855 480521 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Negative_regulation TNF MAPK9 9439626 482863 Tyrosine kinase and *inhibition* of [TNF-alpha-] and EGF stimulated IEC-6 cell growth . Negative_regulation TNF MAPK9 9864164 582637 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Negative_regulation TNF MAPKAP1 11961404 932601 Both and NP *inhibited* the [TNF-alpha] induced VCAM-1 mRNA expression in a dose dependent manner ( 0.25-2 mM ) . Negative_regulation TNF MAPKAP1 11961404 932607 *inhibited* the [TNF-alpha-] induced NF-kappaB binding activity . Negative_regulation TNF MAPKAP1 12399621 1009118 *inhibited* [TNF-alpha-] or IL-1beta induced MCP-1 mRNA expression in a dose dependent manner and also suppressed the MCP-1 protein expression . Negative_regulation TNF MAPKAPK2 16849504 1588480 We show that MK2 ( -/- ) and ( +/- ) mice exhibit decreased disease incidence and severity in the CIA disease model and *reduced* [TNF-alpha] and IL-6 serum levels following LPS/d-Gal treatment compared with wild-type mice . Negative_regulation TNF MAPKAPK2 17485113 1744266 Distinct *role* of in the regulation of [TNF] gene expression by Toll-like receptor 7 and 9 ligands . Negative_regulation TNF MAPKAPK2 19359247 2081237 In this study , we investigated the *role* of in the regulation of [tumor necrosis factor-alpha (TNF-alpha)] and interleukin (IL)-12 , two of the major inflammatory cytokines produced by macrophages stimulated with GPIs . Negative_regulation TNF MAPKAPK2 19657354 2186080 Surprisingly , deficiency did not inhibit edema formation in subacute 2,4-dinitrochlorobenzene ( DNCB ) -induced contact allergy and even *increased* [TNF-alpha] and IL-1beta levels as well as granulocyte infiltration in diseased ears . Negative_regulation TNF MAPKAPK2 9916683 587468 SB 203580 , a selective inhibitor of p38 , blocked p38 and activation in the T cell clone but did not completely *inhibit* [TNF-alpha] release . Negative_regulation TNF MBL2 18070904 1868046 Evasion of innate immune responses : evidence for *inhibition* of [tumor necrosis factor] alpha production by macrophages in response to Blastomyces dermatitidis . Negative_regulation TNF MBL2 7529289 291443 Activation of human monocytes by streptococcal rhamnose glucose polymers is mediated by CD14 antigen , and *inhibits* [TNF-alpha] release . Negative_regulation TNF MBTPS1 20577214 2280424 These results also highlight the key *role* of SphK1 and its product in [TNF-alpha] signalling and the canonical NF-kappaB activation pathway important in inflammatory , antiapoptotic and immune processes . Negative_regulation TNF MBTPS1 20624458 2304148 Although our experimental data clearly show the mediatory *role* of sphingosine kinase (SK) derived in the [TNF-alpha] and the LPS induced activation of NF-kB , exogenously added S1P failed to trigger this transcription factor . Negative_regulation TNF MC1R 12895657 1118047 The inhibitory efficacy of 154N-5 on TNF-alpha secretion in both models was similar to the nonselective agonist NDP-alpha-melanocyte stimulating hormone ( NDP-alphaMSH ) , thus , we conclude that inhibition of [TNF-alpha] secretion by melanocortin peptides is *mediated* by . Negative_regulation TNF MC1R 19656324 2157650 Constitutive expression of in HaCaT keratinocytes *inhibits* basal and UVB induced [TNF-alpha] production . Negative_regulation TNF MCAT 20171598 2215472 Induction of interleukin 1beta (IL-1beta) , [TNF-alpha] , and macrophage inflammatory protein-2 ( MIP-2 ) in the colon was *attenuated* by dietary . Negative_regulation TNF MDM1 24556631 2924496 The present study demonstrates that AZM and *suppress* the synthesis of mucin and [TNF-a] from human airway epithelial cells . Negative_regulation TNF MDM2 24556631 2924497 The present study demonstrates that AZM and *suppress* the synthesis of mucin and [TNF-a] from human airway epithelial cells . Negative_regulation TNF MDM4 24556631 2924498 The present study demonstrates that AZM and *suppress* the synthesis of mucin and [TNF-a] from human airway epithelial cells . Negative_regulation TNF MED1 10374812 623163 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED1 21933115 2562374 Immunohistochemical staining revealed that suppressed production of NF-?B p65 subunit in the joints and *attenuated* the productions of IL-1ß and [TNF-a] in serum from AA . Negative_regulation TNF MED10 10374812 623157 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED11 10374812 623160 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED13 10374812 623144 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED13L 10374812 623145 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED14 10374812 623149 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED15 10374812 623138 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED16 10374812 623140 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED17 10374812 623151 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED18 10374812 623156 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED19 10374812 623159 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED20 10374812 623139 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED21 10374812 623136 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED22 10374812 623137 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED23 10374812 623150 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED24 10374812 623146 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED25 10374812 623158 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED26 10374812 623152 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED27 10374812 623153 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED29 10374812 623148 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED30 10374812 623147 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED31 10374812 623155 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED4 10374812 623141 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED6 10374812 623142 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED7 10374812 623154 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MED8 10374812 623143 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF MET 24420848 2917888 After 12 h-incubation , significantly *inhibited* the increase of MDA , [TNF-a] , LDH and CK levels induced by high glucose , especially at the 5 × 10 ( -5 ) to 10 ( -4 ) mol/L concentrations while inhibiting the decrease of SOD level . Negative_regulation TNF MIB2 11854271 929304 A interacts with receptor interacting protein ( RIP ) and *inhibits* [tumor necrosis factor (TNF)-] and IL1 induced NF-kappa B activation . Negative_regulation TNF MICE 11179286 786781 pretreated with cyclosporine ( Cs ) or neutralizing antibodies against gamma interferon ( IFN-gamma ) did not develop lethal LPS hypersensitivity when injected with TSST-1 , and these agents *reduced* the enhancement effect of TSST-1 on LPS induced serum [TNF-alpha] by 99 and 85 % , respectively . Negative_regulation TNF MICE 18667700 1948043 lacking ST2 , the IL-33 receptor alpha-chain , developed attenuated collagen induced arthritis ( CIA ) and *reduced* ex vivo collagen-specific induction of proinflammatory cytokines ( IL-17 , [TNFalpha] , and IFNgamma ) , and antibody production . Negative_regulation TNF MIF 16224818 1489330 Recombinant counter *regulated* in a dose dependent fashion dexamethasone inhibition of [TNF] and IL-8 production by RAW 264.7 macrophages and U-937 promonocytes stimulated with lipopolysaccharides (LPS) or with LPS plus phorbol 12-myristate 13-acetate . Negative_regulation TNF MIF 16891616 1632573 The critical role of NADPH oxidase for GIF and PACAP38 neuroprotection against LPS induced DA neurotoxicity was demonstrated using neuron-glia cultures from mice deficient in NADPH oxidase ( PHOX ( -/- ) ) , where PACAP38 and *reduced* [tumor necrosis factor] alpha production and were neuroprotective only in PHOX ( +/+ ) cultures and not in PHOX ( -/- ) cultures . Negative_regulation TNF MIF 17324399 1711870 Progesterone *enhanced* TNBS induced MIF ( P < .001 ) and [TNF-alpha] ( P < .01 ) production , while EB decreased ( P < .01 ) and IL-beta levels ( P < .01 ) . Negative_regulation TNF MIPEP 10667632 665652 Neutralization of endotoxin by polymyxin B abrogated > 80 % of [TNF-alpha] induction by CAPs samples , but *inhibited* production by only approximately 40 % . Negative_regulation TNF MIR146A 21562054 2470218 *regulates* both transcription silencing and translation disruption of [TNF-a] during TLR4 induced gene reprogramming . Negative_regulation TNF MLN 24600451 2920580 The NEDD8 activating enzyme inhibitor , however , which inhibits classical and alternative NF?B signaling , *blocked* [TNF-] and TWEAK induced TRAF1 expression . Negative_regulation TNF MLST8 22351078 2561117 The aim of this study was to investigate the *role* of in myocardial [TNF-a] expression during endotoxemia . Negative_regulation TNF MLYCD 15943174 1415776 Moreover , 10 ( -4 ) and 10 ( -5 ) M Zn and 10 ( -5 ) M Se strongly upregulated IFN-gamma ( a Th1 cytokine ) release , even in *presence* of 10 ( -5 ) , and reduced the inhibitory effects of Cd on PBMC proliferation and [TNF-alpha] release . Negative_regulation TNF MLYCD 21701985 2475927 The results indicated that effectively *inhibited* [TNF-a] , MIP-2 , and IL-6 release and NO production from LPS stimulated RAW 264.7 cells by down regulating mRNA accumulation and protein expression of mCD14 specifically . Negative_regulation TNF MMD 22203480 2568861 Overexpression of in macrophages *increased* the production of [TNF-a] and NO upon LPS stimulation . Negative_regulation TNF MME 23640758 2833770 In RAW 264.7 cells , *suppressed* lipopolysaccharide (LPS) induced IL-1ß and [TNF-a] expression about 2 fold stronger than sulforaphane , whereas both pure compounds and SFE suppressed inflammatory nitric oxide ( NO ) production . Negative_regulation TNF MMP12 21827494 2463288 Furthermore , the *inhibited* LPS stimulated NO , PGE ( 2 ) , IL-1ß and [TNF-a] release and inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 protein expression . Negative_regulation TNF MMP12 21827494 2463292 These results suggest that among mechanisms of the anti-inflammatory response , the *inhibited* the production of NO , PGE ( 2 ) , IL-1ß and [TNF-a] by downregulating iNOS and COX-2 gene expression in macrophages and worked through the action of HO-1 . Negative_regulation TNF MMP2 21215448 2392065 In conclusion , [TNF-a] can inhibit trophoblast-like cells ( JEG-3 ) integration into maternal endothelial cellular networks , and this process *involves* the inhibition of and a failure of integrins switch from a ( 6 ) ß ( 4 ) to a ( 1 ) ß ( 1 . ) Negative_regulation TNF MMP2 21518085 2423049 We also confirmed that [TNF-a] *induced* up-regulation of active TGF-ß1 and exogenous TGF-ß1 induced down-regulation of synthesis in lung fibroblasts . Negative_regulation TNF MMP2 21573233 2430246 In summary , our study implies a *role* of in the regulation of [TNF-a] mediated constitutive NF-?B activation and Fas mediated JNK mediated apoptosis in glioma xenograft cells in vitro and in vivo . Negative_regulation TNF MMP3 17060126 1637164 MMP-3 inhibition ameliorates intestinal damage without apparently affecting either TNF-alpha or TACE production and the dose-response curve suggests that the beneficial effect of the so-called TACE inhibitor is actually mainly mediated via inhibition rather than [TNF-alpha] *inhibition* . Negative_regulation TNF MMP9 10943866 721464 Suppression of [tumor necrosis factor] alpha *induced* production by the introduction of a super-repressor form of inhibitor of nuclear factor kappaBalpha complementary DNA into immortalized human salivary gland acinar cells . Negative_regulation TNF MMP9 11813159 907414 Chemokines increased [TNF-alpha] mRNA levels and protein release in monocytes and THP-1 cells , and neutralizing anti-TNF-alpha antibodies *inhibited* CCL2 induced release . Negative_regulation TNF MMP9 23811455 2808170 TCDCA in dosages of 0.05 and 0.1g/kg can extremely significantly decrease the pulmonary coefficient in the model mice ( P > 0.01 ) , TCDCA in a dosage of 0.2g/kg significantly decreased the pulmonary coefficient in the model mice ( P < 0.05 ) ; TCDCA in dosages of 0.05 and 0.1g/kg significantly reduce the pathological damages on their lungs ; TCDCA can extremely significantly decrease the expression levels of [TNF-a] and TIMP-2 in pulmonary tissues in the pulmonary fibrosis mice ( P > 0.01 ) , the expression level of extremely significantly *increased* ( P > 0.01 ) , while it has no significant effects on MMP2 . Negative_regulation TNF MOCOS 21984710 2539614 In Exp. 3 ( n = 6 pigs ) , when MOS was directly applied in vitro , the pattern of cytokine production by LPS activated AM was similar to that observed ex vivo , as *suppressed* LPS induced [TNF-a] ( P < 0.001 ) and enhanced LPS induced IL-10 ( P = 0.028 ) . Negative_regulation TNF MOCOS 21984710 2539616 These data establish that and MRF *suppress* LPS induced [TNF-a] secretions by AM . Negative_regulation TNF MOG 16415102 1514490 We found that both IFN-gamma and IL-17 production and proliferation were reduced in IL-1-/- T cells upon *stimulation* with , while IFN-gamma , IL-17 and [tumor necrosis factor-alpha] production and proliferation were enhanced in IL-1Ra-/- T cells . Negative_regulation TNF MOK 20883179 2326682 *inhibited* [TNF-a-] and IL-1ß induced nuclear factor ?B ( NF-?B ) activation . Negative_regulation TNF MOK 20883179 2326685 These results demonstrate that *attenuates* [TNF-a-] and IL-1ß induced production of CTACK/CCL27 in human HaCaT keratinocytes by inhibiting NF-?B activation and induction of HO-1 . Negative_regulation TNF MOK 22418033 2582634 Danshensu partly blocked the expression of , p-p38 , and COX-2 , and NF-?B activation , and *inhibited* the increase of [TNF-a] , IL-6 , and PGE2 . Negative_regulation TNF MOK 23755753 2797803 Soluble ( sRAGE ) *reduced* S100B dependent secretion of [TNF-alpha] but did not decrease S100B dependent secretion of IL-6 . Negative_regulation TNF MPG 10921588 717438 also *reduced* [TNF-alpha] and IL-6 mRNA expression ( as measured by reverse transcriptase-polymerase chain reaction ) assessed in peritoneal macrophages isolated from shock rats . Negative_regulation TNF MPG 10921588 717440 Finally , in vitro experiments showed that also markedly *reduced* the mRNA expression and release of [TNF-alpha] and IL-6 in peritoneal macrophages isolated from normal rats and subjected to hypoxia and reoxygenation . Negative_regulation TNF MPL 15147963 1248265 HCT and *inhibited* the production of the cytokines [TNFalpha] and IL-8 . Negative_regulation TNF MPO 16883632 1594736 Shen-Fu ( 10,100 mg/kg ) decreased activity and wet/dry weight ratio and *inhibited* [TNF-alpha] and IL-6 production , endotoxin induced NF-kappa B activation . Negative_regulation TNF MPO 21070844 2376542 IG significantly ameliorated macroscopic damage and histological changes , reduced the activity of , depressed MDA and NO levels and effectively *inhibited* the protein and mRNA expressions of NF-?Bp65 , [TNF-a] and IL-6 in the colon tissues of experimental colitis in a dose dependent manner . Negative_regulation TNF MPO 21316771 2489338 NaHS significantly reduced the myocardial infarct size ( 31.2 ± 4.7 % ) , *inhibited* the production of lipid peroxidation , activity , and cell apoptosis , and downregulated expression of caspase-3 , Fas , FasL , and [TNF-a] , which had been elevated by MIR , while PAG further increased the myocardial infarct size ( 58.3 ± 5.9 % ) , and displayed opposite effects . Negative_regulation TNF MPO 9609097 508728 Reverse transcription-polymerase chain reaction and immunohistochemical techniques were used to demonstrate that 24 h to 1 wk after UVB-light irradiation , PTX inhibited UVB induced TNF-alpha gene expression , *inhibited* the increase in epidermal [TNF-alpha] protein synthesis , blocked the increase in epidermal proliferation observed after exposure to UVB light , and decreased production of by neutrophils infiltrating into the dermis . Negative_regulation TNF MPP1 7957562 278061 The biological activity of the pro-inflammatory cytokine , tumor necrosis factor (TNF)-alpha depends on the level of TNF-alpha itself , the expression of the p55 and p75 cell surface receptors for TNF on target cells and the concentrations of the natural *inhibitors* of [TNF-alpha] , the soluble and p75 TNF receptors (TNF-R) . Negative_regulation TNF MRXS5 11160202 781501 ATP inhibition of [TNF-alpha] and IL-12 production by mature DCs was not *mediated* by or elevation of intracellular cAMP and did not require ATP degradation . Negative_regulation TNF MRXS5 22504638 2589506 Finally , released from H ( 2 ) O ( 2 ) -stimulated astrocytes *inhibited* microglial [TNF-a] expression . Negative_regulation TNF MSC 20169081 2215405 Using mouse thioglycolate elicited peritoneal macrophages ( M ) stimulated with LPS , we found that markedly *suppressed* the production of the inflammatory cytokines [TNF-alpha] , IL-6 , IL-12p70 and interferon-gamma while increased the production of IL-10 and IL-12p40 . Negative_regulation TNF MSH2 10486285 644762 peptides *inhibit* production of nitric oxide and [tumor necrosis factor-alpha] by microglial cells activated with beta-amyloid and interferon gamma . Negative_regulation TNF MSH2 10816651 580221 *reduces* chemotaxis of human neutrophils and production of [TNF-alpha] , neopterin , and NO by monocytes . Negative_regulation TNF MSH2 10816651 580226 In research on septic patients , *inhibited* release of [TNF-alpha] , interleukin-1 beta (IL-1 beta) , and interleukin-8 (IL-8) in whole blood samples in vitro . Negative_regulation TNF MSH2 12453626 1020841 This study 's objective was to determine whether the anti-inflammatory neuropeptide can *suppress* postischemic activation of intracerebral [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) gene expression . Negative_regulation TNF MSH2 12485424 1024995 We have investigated in detail the ability of three peptides to *inhibit* [tumor necrosis factor] alpha stimulated NFkappaB activation in nonpigmentary HaCaT keratinocytes ( alpha-MSH , L-Lys-L-Pro-L-Val , and L-Lys-L-Pro-D-Val ) and two adrenocorticotropic hormone ( ACTH ) peptides ( 1-17 and 1-39 ) , reported to be present in skin tissue . Negative_regulation TNF MSH2 12816950 1120777 Here , we have investigated signaling pathways by which *inhibits* lipopolysaccharide (LPS) induced [TNF-alpha] production in leukocytes such as THP-1 cells . Negative_regulation TNF MSH2 16274855 1518440 It has previously been shown in skin cell keratinocytes and melanocytes/melanoma cells that peptides *inhibit* [TNF-alpha] stimulated NF-kappaB activity and intercellular adhesion molecule-1 ( ICAM-1 ) upregulation . Negative_regulation TNF MSH2 16679696 1559499 *inhibited* LPS induced [TNF-alpha] production , and alpha-MSH simultaneously augmented production of interleukin (IL)-10 by PBMC . Negative_regulation TNF MSH2 20619468 2316348 In conclusion , our data show that *reduces* [TNF-a] expression in hypothalamic neurons by a mechanism which could be mediated by CREB . Negative_regulation TNF MSH2 21828180 2485466 *inhibited* IL-6 and [TNF-a] expression , decreased histological damage , and increased neural efferent activity . Negative_regulation TNF MSH2 23338711 2753654 inhibited vascular leakage , leukocyte rolling , and adhesion and *reduced* peritoneal macrophage inflammatory protein 2 , but not [TNF-alpha] , IL-1beta , IL-10 , and keratinocyte derived chemokine production . Negative_regulation TNF MSH2 9045742 416630 This indicates that can act directly on brain cells to *inhibit* their production of [TNF-alpha] . Negative_regulation TNF MSH2 9700761 525248 In separate experiments on normal peripheral blood mononuclear cells ( PBMC ) , ( 1-13 ) *inhibited* production of IL-1 beta and [TNF alpha] induced by HIV envelope glycoprotein gp 120 . Negative_regulation TNF MSH2 9730684 530283 they produced [TNF-alpha] and nitric oxide in response to challenge , and production of both was *reduced* by . Negative_regulation TNF MSH3 10486285 644763 peptides *inhibit* production of nitric oxide and [tumor necrosis factor-alpha] by microglial cells activated with beta-amyloid and interferon gamma . Negative_regulation TNF MSH3 10816651 580222 *reduces* chemotaxis of human neutrophils and production of [TNF-alpha] , neopterin , and NO by monocytes . Negative_regulation TNF MSH3 10816651 580227 In research on septic patients , *inhibited* release of [TNF-alpha] , interleukin-1 beta (IL-1 beta) , and interleukin-8 (IL-8) in whole blood samples in vitro . Negative_regulation TNF MSH3 12453626 1020842 This study 's objective was to determine whether the anti-inflammatory neuropeptide can *suppress* postischemic activation of intracerebral [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) gene expression . Negative_regulation TNF MSH3 12485424 1024996 We have investigated in detail the ability of three peptides to *inhibit* [tumor necrosis factor] alpha stimulated NFkappaB activation in nonpigmentary HaCaT keratinocytes ( alpha-MSH , L-Lys-L-Pro-L-Val , and L-Lys-L-Pro-D-Val ) and two adrenocorticotropic hormone ( ACTH ) peptides ( 1-17 and 1-39 ) , reported to be present in skin tissue . Negative_regulation TNF MSH3 12816950 1120778 Here , we have investigated signaling pathways by which *inhibits* lipopolysaccharide (LPS) induced [TNF-alpha] production in leukocytes such as THP-1 cells . Negative_regulation TNF MSH3 16274855 1518441 It has previously been shown in skin cell keratinocytes and melanocytes/melanoma cells that peptides *inhibit* [TNF-alpha] stimulated NF-kappaB activity and intercellular adhesion molecule-1 ( ICAM-1 ) upregulation . Negative_regulation TNF MSH3 16679696 1559500 *inhibited* LPS induced [TNF-alpha] production , and alpha-MSH simultaneously augmented production of interleukin (IL)-10 by PBMC . Negative_regulation TNF MSH3 20619468 2316349 In conclusion , our data show that *reduces* [TNF-a] expression in hypothalamic neurons by a mechanism which could be mediated by CREB . Negative_regulation TNF MSH3 21828180 2485467 *inhibited* IL-6 and [TNF-a] expression , decreased histological damage , and increased neural efferent activity . Negative_regulation TNF MSH3 23338711 2753655 inhibited vascular leakage , leukocyte rolling , and adhesion and *reduced* peritoneal macrophage inflammatory protein 2 , but not [TNF-alpha] , IL-1beta , IL-10 , and keratinocyte derived chemokine production . Negative_regulation TNF MSH3 9045742 416631 This indicates that can act directly on brain cells to *inhibit* their production of [TNF-alpha] . Negative_regulation TNF MSH3 9700761 525249 In separate experiments on normal peripheral blood mononuclear cells ( PBMC ) , ( 1-13 ) *inhibited* production of IL-1 beta and [TNF alpha] induced by HIV envelope glycoprotein gp 120 . Negative_regulation TNF MSH3 9730684 530284 they produced [TNF-alpha] and nitric oxide in response to challenge , and production of both was *reduced* by . Negative_regulation TNF MSH4 10486285 644764 peptides *inhibit* production of nitric oxide and [tumor necrosis factor-alpha] by microglial cells activated with beta-amyloid and interferon gamma . Negative_regulation TNF MSH4 10816651 580223 *reduces* chemotaxis of human neutrophils and production of [TNF-alpha] , neopterin , and NO by monocytes . Negative_regulation TNF MSH4 10816651 580228 In research on septic patients , *inhibited* release of [TNF-alpha] , interleukin-1 beta (IL-1 beta) , and interleukin-8 (IL-8) in whole blood samples in vitro . Negative_regulation TNF MSH4 12453626 1020843 This study 's objective was to determine whether the anti-inflammatory neuropeptide can *suppress* postischemic activation of intracerebral [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) gene expression . Negative_regulation TNF MSH4 12485424 1024997 We have investigated in detail the ability of three peptides to *inhibit* [tumor necrosis factor] alpha stimulated NFkappaB activation in nonpigmentary HaCaT keratinocytes ( alpha-MSH , L-Lys-L-Pro-L-Val , and L-Lys-L-Pro-D-Val ) and two adrenocorticotropic hormone ( ACTH ) peptides ( 1-17 and 1-39 ) , reported to be present in skin tissue . Negative_regulation TNF MSH4 12816950 1120779 Here , we have investigated signaling pathways by which *inhibits* lipopolysaccharide (LPS) induced [TNF-alpha] production in leukocytes such as THP-1 cells . Negative_regulation TNF MSH4 16274855 1518442 It has previously been shown in skin cell keratinocytes and melanocytes/melanoma cells that peptides *inhibit* [TNF-alpha] stimulated NF-kappaB activity and intercellular adhesion molecule-1 ( ICAM-1 ) upregulation . Negative_regulation TNF MSH4 16679696 1559501 *inhibited* LPS induced [TNF-alpha] production , and alpha-MSH simultaneously augmented production of interleukin (IL)-10 by PBMC . Negative_regulation TNF MSH4 20619468 2316350 In conclusion , our data show that *reduces* [TNF-a] expression in hypothalamic neurons by a mechanism which could be mediated by CREB . Negative_regulation TNF MSH4 21828180 2485468 *inhibited* IL-6 and [TNF-a] expression , decreased histological damage , and increased neural efferent activity . Negative_regulation TNF MSH4 23338711 2753656 inhibited vascular leakage , leukocyte rolling , and adhesion and *reduced* peritoneal macrophage inflammatory protein 2 , but not [TNF-alpha] , IL-1beta , IL-10 , and keratinocyte derived chemokine production . Negative_regulation TNF MSH4 9045742 416632 This indicates that can act directly on brain cells to *inhibit* their production of [TNF-alpha] . Negative_regulation TNF MSH4 9700761 525250 In separate experiments on normal peripheral blood mononuclear cells ( PBMC ) , ( 1-13 ) *inhibited* production of IL-1 beta and [TNF alpha] induced by HIV envelope glycoprotein gp 120 . Negative_regulation TNF MSH4 9730684 530285 they produced [TNF-alpha] and nitric oxide in response to challenge , and production of both was *reduced* by . Negative_regulation TNF MSH5 10486285 644765 peptides *inhibit* production of nitric oxide and [tumor necrosis factor-alpha] by microglial cells activated with beta-amyloid and interferon gamma . Negative_regulation TNF MSH5 10816651 580224 *reduces* chemotaxis of human neutrophils and production of [TNF-alpha] , neopterin , and NO by monocytes . Negative_regulation TNF MSH5 10816651 580229 In research on septic patients , *inhibited* release of [TNF-alpha] , interleukin-1 beta (IL-1 beta) , and interleukin-8 (IL-8) in whole blood samples in vitro . Negative_regulation TNF MSH5 12453626 1020844 This study 's objective was to determine whether the anti-inflammatory neuropeptide can *suppress* postischemic activation of intracerebral [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) gene expression . Negative_regulation TNF MSH5 12485424 1024998 We have investigated in detail the ability of three peptides to *inhibit* [tumor necrosis factor] alpha stimulated NFkappaB activation in nonpigmentary HaCaT keratinocytes ( alpha-MSH , L-Lys-L-Pro-L-Val , and L-Lys-L-Pro-D-Val ) and two adrenocorticotropic hormone ( ACTH ) peptides ( 1-17 and 1-39 ) , reported to be present in skin tissue . Negative_regulation TNF MSH5 12816950 1120780 Here , we have investigated signaling pathways by which *inhibits* lipopolysaccharide (LPS) induced [TNF-alpha] production in leukocytes such as THP-1 cells . Negative_regulation TNF MSH5 16274855 1518443 It has previously been shown in skin cell keratinocytes and melanocytes/melanoma cells that peptides *inhibit* [TNF-alpha] stimulated NF-kappaB activity and intercellular adhesion molecule-1 ( ICAM-1 ) upregulation . Negative_regulation TNF MSH5 16679696 1559502 *inhibited* LPS induced [TNF-alpha] production , and alpha-MSH simultaneously augmented production of interleukin (IL)-10 by PBMC . Negative_regulation TNF MSH5 20619468 2316351 In conclusion , our data show that *reduces* [TNF-a] expression in hypothalamic neurons by a mechanism which could be mediated by CREB . Negative_regulation TNF MSH5 21828180 2485469 *inhibited* IL-6 and [TNF-a] expression , decreased histological damage , and increased neural efferent activity . Negative_regulation TNF MSH5 23338711 2753657 inhibited vascular leakage , leukocyte rolling , and adhesion and *reduced* peritoneal macrophage inflammatory protein 2 , but not [TNF-alpha] , IL-1beta , IL-10 , and keratinocyte derived chemokine production . Negative_regulation TNF MSH5 9045742 416633 This indicates that can act directly on brain cells to *inhibit* their production of [TNF-alpha] . Negative_regulation TNF MSH5 9700761 525251 In separate experiments on normal peripheral blood mononuclear cells ( PBMC ) , ( 1-13 ) *inhibited* production of IL-1 beta and [TNF alpha] induced by HIV envelope glycoprotein gp 120 . Negative_regulation TNF MSH5 9730684 530286 they produced [TNF-alpha] and nitric oxide in response to challenge , and production of both was *reduced* by . Negative_regulation TNF MSH6 10486285 644766 peptides *inhibit* production of nitric oxide and [tumor necrosis factor-alpha] by microglial cells activated with beta-amyloid and interferon gamma . Negative_regulation TNF MSH6 10816651 580225 *reduces* chemotaxis of human neutrophils and production of [TNF-alpha] , neopterin , and NO by monocytes . Negative_regulation TNF MSH6 10816651 580230 In research on septic patients , *inhibited* release of [TNF-alpha] , interleukin-1 beta (IL-1 beta) , and interleukin-8 (IL-8) in whole blood samples in vitro . Negative_regulation TNF MSH6 12453626 1020845 This study 's objective was to determine whether the anti-inflammatory neuropeptide can *suppress* postischemic activation of intracerebral [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) gene expression . Negative_regulation TNF MSH6 12485424 1024999 We have investigated in detail the ability of three peptides to *inhibit* [tumor necrosis factor] alpha stimulated NFkappaB activation in nonpigmentary HaCaT keratinocytes ( alpha-MSH , L-Lys-L-Pro-L-Val , and L-Lys-L-Pro-D-Val ) and two adrenocorticotropic hormone ( ACTH ) peptides ( 1-17 and 1-39 ) , reported to be present in skin tissue . Negative_regulation TNF MSH6 12816950 1120781 Here , we have investigated signaling pathways by which *inhibits* lipopolysaccharide (LPS) induced [TNF-alpha] production in leukocytes such as THP-1 cells . Negative_regulation TNF MSH6 16274855 1518444 It has previously been shown in skin cell keratinocytes and melanocytes/melanoma cells that peptides *inhibit* [TNF-alpha] stimulated NF-kappaB activity and intercellular adhesion molecule-1 ( ICAM-1 ) upregulation . Negative_regulation TNF MSH6 16679696 1559503 *inhibited* LPS induced [TNF-alpha] production , and alpha-MSH simultaneously augmented production of interleukin (IL)-10 by PBMC . Negative_regulation TNF MSH6 20619468 2316352 In conclusion , our data show that *reduces* [TNF-a] expression in hypothalamic neurons by a mechanism which could be mediated by CREB . Negative_regulation TNF MSH6 21828180 2485470 *inhibited* IL-6 and [TNF-a] expression , decreased histological damage , and increased neural efferent activity . Negative_regulation TNF MSH6 23338711 2753658 inhibited vascular leakage , leukocyte rolling , and adhesion and *reduced* peritoneal macrophage inflammatory protein 2 , but not [TNF-alpha] , IL-1beta , IL-10 , and keratinocyte derived chemokine production . Negative_regulation TNF MSH6 9045742 416634 This indicates that can act directly on brain cells to *inhibit* their production of [TNF-alpha] . Negative_regulation TNF MSH6 9700761 525252 In separate experiments on normal peripheral blood mononuclear cells ( PBMC ) , ( 1-13 ) *inhibited* production of IL-1 beta and [TNF alpha] induced by HIV envelope glycoprotein gp 120 . Negative_regulation TNF MSH6 9730684 530287 they produced [TNF-alpha] and nitric oxide in response to challenge , and production of both was *reduced* by . Negative_regulation TNF MST1 21528357 2458510 markedly *inhibited* expression of inflammatory cytokines ( IL-1ß , [TNF-a] and IL-18 ) , chemokines ( MIP-1 , MCP-1 and RANTES ) and iNOS , NO , COX-2 and PGE ( 2 ) in RASF stimulated by LPS . Negative_regulation TNF MT-CO2 20181940 2281446 Elevated selectively *inhibits* interleukin-6 and [tumor necrosis factor] expression and decreases phagocytosis in the macrophage . Negative_regulation TNF MT-CO2 20397120 2240584 , but not hypoxia , *induced* a significant reduction in the release of [TNF-alpha] and IL-8 as well as a significant increase in the release of IL-10 and IL-1 beta within the first 4 h after incubation . Negative_regulation TNF MT-CO2 9872684 556948 We sought to determine whether carbonic anhydrase inhibition with acetazolamide would prevent *mediated* inhibition of LPS stimulated [TNF] release . Negative_regulation TNF MT-CO2 9872684 556949 This *mediated* inhibition of [TNF] was associated with normal levels of TNF mRNA . Negative_regulation TNF MT-TP 19593846 2105351 Quantitative real-time PCR assays showed that CE treatment decreased the mRNA expression of IL-1beta , IL-6 and [TNF-alpha] , improved the mRNA expression of IR , IRS1 , IRS2 , PI3K and Akt1 , *inhibited* CD36 , , and PTEN , and enhanced the impaired SREBP-1c expression in TNF-alpha treated enterocytes . Negative_regulation TNF MT1F 8106906 240350 In all instances *inhibited* [TNF-alpha] release when the monocytes were stimulated with smooth type LPS , but not with LPS isolated from rough mutants . Negative_regulation TNF MT3 20046642 2177379 induction *reduces* caspase-3 activity and [TNFalpha] levels with preservation of cognitive function and intact hippocampal neurons in carmustine treated rats . Negative_regulation TNF MT4 20046642 2177378 induction *reduces* caspase-3 activity and [TNFalpha] levels with preservation of cognitive function and intact hippocampal neurons in carmustine treated rats . Negative_regulation TNF MTA1 16786535 1612637 Indeed , *suppressed* the production of proinflammatory genes and cytokines ( interferon-gamma , [tumor necrosis factor-alpha] , and inducible nitric oxide synthase ) and increased the production of antiinflammatory cytokines ( interleukin-10 ) . Negative_regulation TNF MTA1 18393372 1899371 We previously showed that S-adenosylmethionine ( SAMe ) and its metabolite *blocked* lipopolysaccharide (LPS) induced [tumor necrosis factor alpha (TNFalpha)] expression in RAW ( murine macrophage cell line ) and Kupffer cells at the transcriptional level without affecting nuclear factor kappa B nuclear binding . Negative_regulation TNF MTA1 22159228 2548844 S-adenosylmethionine ( SAMe ) and its metabolite can *inhibit* lipopolysaccharide induced [TNF-a] expression in macrophages . Negative_regulation TNF MTA2 16786535 1612638 Indeed , *suppressed* the production of proinflammatory genes and cytokines ( interferon-gamma , [tumor necrosis factor-alpha] , and inducible nitric oxide synthase ) and increased the production of antiinflammatory cytokines ( interleukin-10 ) . Negative_regulation TNF MTA2 18393372 1899372 We previously showed that S-adenosylmethionine ( SAMe ) and its metabolite *blocked* lipopolysaccharide (LPS) induced [tumor necrosis factor alpha (TNFalpha)] expression in RAW ( murine macrophage cell line ) and Kupffer cells at the transcriptional level without affecting nuclear factor kappa B nuclear binding . Negative_regulation TNF MTA2 22159228 2548845 S-adenosylmethionine ( SAMe ) and its metabolite can *inhibit* lipopolysaccharide induced [TNF-a] expression in macrophages . Negative_regulation TNF MTA3 16786535 1612636 Indeed , *suppressed* the production of proinflammatory genes and cytokines ( interferon-gamma , [tumor necrosis factor-alpha] , and inducible nitric oxide synthase ) and increased the production of antiinflammatory cytokines ( interleukin-10 ) . Negative_regulation TNF MTA3 18393372 1899370 We previously showed that S-adenosylmethionine ( SAMe ) and its metabolite *blocked* lipopolysaccharide (LPS) induced [tumor necrosis factor alpha (TNFalpha)] expression in RAW ( murine macrophage cell line ) and Kupffer cells at the transcriptional level without affecting nuclear factor kappa B nuclear binding . Negative_regulation TNF MTA3 22159228 2548843 S-adenosylmethionine ( SAMe ) and its metabolite can *inhibit* lipopolysaccharide induced [TNF-a] expression in macrophages . Negative_regulation TNF MTOR 19447494 2090729 Pharmacologic inhibition of with rapamycin inhibited LPS induction of IL-10 mRNA and protein , and *enhanced* the expression of TF and the proinflammatory cytokine [TNFalpha] in WT PMs . Negative_regulation TNF MTOR 19447494 2090731 The results indicate that dependent IL-10 expression *leads* to inhibition of LPS induction of TF and the proinflammatory cytokine [TNFalpha] in WT macrophages . Negative_regulation TNF MTOR 22025552 2508018 inhibition with rapamycin *enhanced* TLR-4 mediated [TNF-a] release , but suppressed anti-inflammatory IL-10 release . Negative_regulation TNF MTOR 22025552 2508022 Targeted gene silencing of MyD88 ( short hairpin RNA ) and ( RNA interference ) inhibition *resulted* in TLR-4 mediated 70-kDa ribosomal protein S6 kinase activation and enhanced [TNF-a] release , whereas IL-10 release was inhibited in both silenced and nonsilenced HIV ( + ) macrophages . Negative_regulation TNF MTOR 22025552 2508031 Furthermore , inhibition *augmented* LA-induced [TNF-a] release through enhanced and prolonged phosphorylation of ERK1/2 and JNK1/2 MAPK , which was associated with time dependent MKP-1 destabilization . Negative_regulation TNF MTOR 22351078 2561119 The aim of this study was to investigate the *role* of in myocardial [TNF-a] expression during endotoxemia . Negative_regulation TNF MTRF1 10339451 615846 *resulted* in increased expression of IL-1[alpha ] and [TNF[alpha] ] in AMs . Negative_regulation TNF MTX1 17469101 1737457 In contrast , did not *reduce* exudate leukocyte counts or [TNFalpha] levels or increase exudate adenosine levels in CD73-deficient mice . Negative_regulation TNF MTX1 22980653 2674129 GA , MTX , *suppress* the expression of [TNF-a] and IL-1ß in CIA-FLS cells in a time dependent manner , and the suppressing effect is GA+MTX > MTX > GA . Negative_regulation TNF MTX1 23658798 2784766 Indeed , in murine macrophage-like cells ( RAW 264.7 ) , [TNF-a] release and mitogenic activity elicited by specific RAGE stimulation with a truncated monomeric HMGB1 were inhibited in the *presence* of . Negative_regulation TNF MTX1 23869169 2817616 Overall these trials demonstrated that TCZ was effective in the treatment of RA in a number of patient groups , including those with an inadequate response to or [TNF] *inhibition* . Negative_regulation TNF MTX1 9889412 558483 MTX did not inhibit TNF release after injection of Concanavalin A ( ConA ) or anti-CD3 monoclonal antibody ( mAb ) , indicating that does not *inhibit* [TNF] production at the T cell level . Negative_regulation TNF MTX1 9933419 589333 *reduced* spontaneous and IL-15 induced [tumour necrosis factor (TNF)] production by splenic T cells but not by macrophages from healthy mice in vitro in a dose dependent manner . Negative_regulation TNF MYD88 10588727 572144 Expression of a dominant negative form of ( a signaling component required for toll-like receptor signaling ) in a mouse macrophage cell line *blocks* [TNF-alpha] production induced by M. tuberculosis . Negative_regulation TNF MYD88 11238656 790941 Lastly , we demonstrated that a dominant negative mutant could *block* Mtb induced activation of the [TNF-alpha] promoter , but not the inducible NO synthase promoter , in murine macrophages . Negative_regulation TNF MYD88 14977922 1213305 *Role* of in diminished [tumor necrosis factor] alpha production by newborn mononuclear cells in response to lipopolysaccharide . Negative_regulation TNF MYD88 20019195 2200129 Absence of *resulted* in diminished production of inflammatory cytokines such as interleukin-12 , interferon-gamma , and [tumor necrosis factor-alpha] as well as chemoattractants such as monocyte chemotactic protein-1 (MCP-1) and Keratinocyte derived chemokine ( KC ) , and hampered recruitment of effector cells involved in bacterial clearance ( macrophages and neutrophils ) to the infection site . Negative_regulation TNF MYD88 22025552 2508023 Targeted gene silencing of ( short hairpin RNA ) and mTOR ( RNA interference ) inhibition *resulted* in TLR-4 mediated 70-kDa ribosomal protein S6 kinase activation and enhanced [TNF-a] release , whereas IL-10 release was inhibited in both silenced and nonsilenced HIV ( + ) macrophages . Negative_regulation TNF MYLIP 18759964 1980113 Repression of TRAF6 and/or IRAK-1 in THP-1 cells resulted in up to an 86 % reduction in tumor necrosis factor-alpha production , implicating that normal function is *critical* for the regulation of [tumor necrosis factor-alpha] production . Negative_regulation TNF MYLIP 21178010 2378800 Transfection of into THP-1 cells *caused* reduction of [TNF-a] production , mimicking LPS induced cross-tolerance . Negative_regulation TNF MYLIP 21367459 2415866 Transfection of T cells with miR-144* precursor demonstrated that could *inhibit* [TNF-a] and IFN-? production and T cell proliferation . Negative_regulation TNF MYLIP 21611196 2436180 Interestingly , transfection of in LPS activated THP-1 cells *inhibited* [TNF-a] secretion . Negative_regulation TNF MYLIP 21611196 2436182 Conversely , transfection of in LPS activated THP-1 cells increased TTP mRNA expression and *inhibited* [TNF-a] release . Negative_regulation TNF MYLIP 22320217 2575989 Among them , miR-30c-1 ( * ) was noticed because overexpression of ( * ) *triggered* upregulation of transmembrane [tumor necrosis factor-a] expression and enhanced NK cell cytotoxicity against hepatoma cell lines SMMC-7721 and HepG2 . Negative_regulation TNF MYLIP 22950459 2693381 Our data suggest a potential *role* for in the regulation of [TNF-a] expression after ischemia/hypoxia and microglia mediated neuronal injury . Negative_regulation TNF MYLIP 22956783 2684020 Abundance of attenuated ox-LDL induced CD83 and CD40 expression , *inhibited* the secretion of interleukin (IL)-6 and [TNF-a] , and up-regulated IL-10 , an important anti-inflammatory cytokine that was inhibited by ox-LDL . Negative_regulation TNF MYLIP 23361941 2743184 The overexpression of *contributed* to lipopolysaccharide induced expression of proinflammatory cytokines IL-1ß , [TNF-a] , and iNOS in cultured microglia . Negative_regulation TNF MYLIP 24249224 2892590 and the lipopolysaccharide (LPS)-activation of primary human monocyte derived macrophages , where [TNF] ( TNFa ) is *suppressed* by indirectly and miR-34a-3p directly . Negative_regulation TNF MYLIP 24442429 2912801 The *role* of in regulation of induction of [TNF-a] was confirmed by transfecting cells with an inhibitor and a mimic of miR-146a . Negative_regulation TNF MYLK 15701621 1372570 In conclusion , our results indicate for the first time that 1 ) the [TNF-alpha] increase in Caco-2 TJ permeability was *mediated* by an increase in MLCK protein expression , 2 ) the increase in protein expression was regulated by an increase in MLCK mRNA transcription , and 3 ) the increase in Caco-2 TJ permeability required MLCK protein expression dependent increase in MLCK activity . Negative_regulation TNF MYLK 17898319 1843729 obviously *inhibited* the production of interferon-gamma , IL-12 , and [tumor necrosis factor-alpha] by the colonic lymphocytes , but had no influence on IL-4 production . Negative_regulation TNF MYLK 23640484 2795730 In vitro studies demonstrated that *reduced* [tumor necrosis factor-a] , interleukin-6 , and interferon-? induced protein-10 production ; Negative_regulation TNF MYLK 8263039 239244 [TNF] *activation* of DNA fragmentation was blocked by a potent inhibitor of but was unaffected by inhibitors of cAMP or cGMP dependent PKs . Negative_regulation TNF NA 15761843 1389840 In addition , *delayed* monocyte [TNF-alpha] production , thereby maintaining low TNF-alpha levels in plasma during BPDO . Negative_regulation TNF NA 16445696 1517137 In addition , *diminished* the LPS induced increases in nitrate/nitrite , MG , [TNF-a] and IL-1b . Negative_regulation TNF NA 17216608 1717709 Erdosteine , and vitamin E significantly *reduced* the increases in the local production of [TNF-alpha] and heart MPO activity . Negative_regulation TNF NA 17548252 1752083 *inhibited* the activation of TLR2/4 and the induction of [TNF-alpha] resulting from I/R injury via modulating the redox state , thus it may mitigate liver and lung injury following partial hepatic I/R in mice . Negative_regulation TNF NA 17687726 1781857 The secretion of IL-1beta and [TNF-alpha] by silica exposed AM was markedly *inhibited* by and R6G , suggesting that the production of these cytokines is also ROS dependent . Negative_regulation TNF NA 17884964 1797382 and vitamin E significantly *reduced* the increases in the local production of [TNF-alpha] and VEGF , and perivascular MPO activity . Negative_regulation TNF NA 18986521 2006613 and DMSO *inhibit* HA fragment induced expression of [TNF-alpha] and KC protein in alveolar and peritoneal macrophages . Negative_regulation TNF NA 20056085 2193673 *inhibited* the mRNA expression and protein secretion of [TNF-alpha] and IL-6 induced by IL-18 ( P > 0.01 ) . Negative_regulation TNF NA 20560295 2181620 *suppressed* the production of [TNF-alpha] , its soluble receptors , and TGF-beta1 by AMs in a dose dependent manner . Negative_regulation TNF NA 2112750 135488 , which replenishes intracellular glutathione , effectively *inhibits* the [tumor necrosis factor] alpha- or phorbol ester stimulated replication of HIV in acutely infected cell cultures . Negative_regulation TNF NA 21574020 2470232 The results from immunohistochemical staining demonstrated that *suppressed* the expression of IL-1ß and [TNF-a] in the periodontal ligament tissues compared to the vehicle treated group . Negative_regulation TNF NA 21843581 2490588 As expected , *suppressed* the expression of iNOS , COX-2 , and [TNF-a] by blocking proteasome mediated degradation . Negative_regulation TNF NA 22122305 2514614 also *inhibited* the transcription of NF?B , IL-6 , [TNF-a] and COX2 usually induced by LPS . Negative_regulation TNF NA 22727548 2775079 *reduced* [TNF-a] and 4-HNE-protein adducts levels , inflammation , creatine kinase levels , and myonecrosis in diaphragm muscle . Negative_regulation TNF NA 23719546 2801693 also abolished the increase in myogenic determination factor and *reduced* [tumor necrosis factor-a] 8 d after exercise . Negative_regulation TNF NA 23771710 2820272 *attenuated* silica induced increases in [TNF-a] , IL-8 and hsCRP in BALF and serum . Negative_regulation TNF NA 23853776 2817016 normalized tissue and plasma levels of 15-F2t-isoprostane , significantly increased cardiac Brg1 , HO-1 and p-STAT3 protein expression levels and *reduced* [TNF-alpha] and IL-6 , resulting in improved cardiac function . Negative_regulation TNF NA 8443968 213630 also *blocked* [TNF] production in blood and in bronchoalveolar lavage . Negative_regulation TNF NA 9436612 482578 Besides NO , also *blocked* the production of [TNF-alpha] in rat peritoneal macrophages activated with endotoxin . Negative_regulation TNF NA 9581680 503447 On the other hand , kinetic analysis showed that production of nitric oxide ( NO ) and [tumor necrosis factor alpha (TNF-alpha)] by lipopolysaccharide stimulated Kupffer cells was strongly *inhibited* by resveratrol and quercetin but not by . Negative_regulation TNF NA 9933417 589330 Bucillamine and *inhibited* NF-kappaB activation and [tumour necrosis factor-alpha (TNF-alpha)] mRNA expression in human monocytic leukaemia cell line THP-1 , and cytokine production from monocyte cell lines at concentrations > 10-3 M . Negative_regulation TNF NAB1 19812204 2154338 , but not sodium formate , was found to *inhibit* LPS induced expression of inducible NO synthase (iNOS) , proinflammatory cytokines ( [TNF-alpha] and IL-1beta ) and surface markers ( CD11b , CD11c , and CD68 ) in mouse microglia . Negative_regulation TNF NAB2 19812204 2154339 , but not sodium formate , was found to *inhibit* LPS induced expression of inducible NO synthase (iNOS) , proinflammatory cytokines ( [TNF-alpha] and IL-1beta ) and surface markers ( CD11b , CD11c , and CD68 ) in mouse microglia . Negative_regulation TNF NAPA 9389730 467211 In addition to iNOS , lovastatin and also *inhibited* LPS induced expression of [TNF-alpha] , IL-1beta , and IL-6 in rat primary astrocytes , microglia , and macrophages . Negative_regulation TNF NBN 7511678 250180 LPS alone ( 1 ng/ml ) induced a relatively low level of [TNF-alpha] secretion by the macrophages , and the presence of FBS , , or fraction 2 *potentiated* the effect of LPS . Negative_regulation TNF NCF1 11740866 897618 A mutant , defective in the first Src homology 3 (SH3) domain ( p47W ( 193 ) R ) , *diminished* JNK activation by [TNFalpha] . Negative_regulation TNF NCL 19060367 2000029 [ *Role* of cell-surface in lipopolysaccharide stimulated expression and secretion of [TNF-alpha] and IL-1beta ] . Negative_regulation TNF NCL 19060367 2000035 To explore the *role* of cell-surface in lipopolysaccharide (LPS) stimulated expression and secretion of [TNF-alpha] and IL-1beta in human THP-1 monocytes . Negative_regulation TNF NCR1 16044078 1438001 NF-kappaB activation , CD11b/CD18 expression , and the production of [TNF-alpha] , IL-8 , and IL-6 in monocytes and granulocytes were *inhibited* by in vitro . Negative_regulation TNF NCR2 16044078 1438002 NF-kappaB activation , CD11b/CD18 expression , and the production of [TNF-alpha] , IL-8 , and IL-6 in monocytes and granulocytes were *inhibited* by in vitro . Negative_regulation TNF NCR3 16044078 1438000 NF-kappaB activation , CD11b/CD18 expression , and the production of [TNF-alpha] , IL-8 , and IL-6 in monocytes and granulocytes were *inhibited* by in vitro . Negative_regulation TNF NDP 21828180 2485471 *inhibited* IL-6 and [TNF-a] expression , decreased histological damage , and increased neural efferent activity . Negative_regulation TNF NDP 23338711 2753659 inhibited vascular leakage , leukocyte rolling , and adhesion and *reduced* peritoneal macrophage inflammatory protein 2 , but not [TNF-alpha] , IL-1beta , IL-10 , and keratinocyte derived chemokine production . Negative_regulation TNF NELFCD 7589090 333990 The phosphodiesterase inhibitor oxpentifylline ( OXP ) has a number of potentially important immunomodulatory actions which include a selective inhibition of the subset of CD4+ cells in vitro and *inhibition* of [tumor necrosis factor (TNF)-alpha] mRNA transcription . Negative_regulation TNF NES 25206589 2886977 In vivo experiments showed that 50-200 mg/kg Buyang Huanwu Decoction fraction reduced infarct volume and pathological injury in ischemia/reperfusion rats , markedly *inhibited* expression of nuclear factor-?B and [tumor necrosis factor-a] and promoted protein expression in brain tissue . Negative_regulation TNF NFATC2 7982959 281699 The *role* of in cyclosporin A-sensitive [tumor necrosis factor-alpha] gene transcription . Negative_regulation TNF NFE2L2 16177082 1457860 In addition , a dominant negative mutant *inhibited* LPS induced HO-1 mRNA expression but not [TNF-alpha] mRNA expression in THP-1 cells . Negative_regulation TNF NFE2L2 20862369 2325975 Disruption of *enhances* the upregulation of nuclear factor-kappaB activity , [tumor necrosis factor-a] , and matrix metalloproteinase-9 after spinal cord injury in mice . Negative_regulation TNF NFKB1 10203355 606162 Cells were stimulated with [TNF-alpha] or LPS plus IFN-gamma in the *presence* of inhibitors , herbimycin A (HerA) , or the more specific JAK2 inhibitor AG490 . Negative_regulation TNF NFKB1 10416612 631436 In UM-SCC-9 cells that stably expressed IkappaBalphaM , inhibition of constitutive and [tumor necrosis factor-a] *induced* activation , and production of all four cytokines was observed . Negative_regulation TNF NFKB1 10486238 644705 *Role* of transcription factor in asbestos induced [TNFalpha] response from macrophages . Negative_regulation TNF NFKB1 10486238 644711 Inhibition of by SN50 , an inhibitor of NF-kappaB nuclear translocation , or by sequence-specific oligonucleotides directed against the NF-kappaB binding site of TNFalpha promoter *attenuated* the asbestos effect on [TNFalpha] production . Negative_regulation TNF NFKB1 10497896 647556 This is supported by evidence that inhibition of activation by SN50 , a specific NF-kappaB inhibitor , *resulted* in a decrease in the [TNFalpha] production . Negative_regulation TNF NFKB1 10893342 711471 These results suggest that [TNF-alpha] inhibition of hormone stimulated transcriptional activation may be *mediated* by activation of . Negative_regulation TNF NFKB1 10896870 711829 Here we tested the hypothesis that hypoxic suppression of postbacteremic [TNF-alpha] gene expression is transcriptionally *mediated* by reduced activation of . Negative_regulation TNF NFKB1 10924061 718162 Finally , inhibition of ERK phosphorylation reduced , and nuclear translocation *prevented* , [tumor necrosis factor-alpha] production . Negative_regulation TNF NFKB1 10959811 726325 Pretreatment of rats with DDB prevented LPS induced hepatic I-kappaBalpha degradation and the resultant activation , and *inhibited* the LPS induced plasma TNF-alpha protein and hepatic [TNF-alpha] mRNA expression in a dose dependent manner . Negative_regulation TNF NFKB1 11522776 868717 We demonstrate here that the cell differentiation dependent reduction of [TNFalpha] stimulation is not *due* to insufficient activation but correlates with increased synthesis of the monocyte differentiation associated factors CCAAT/enhancer binding protein (C/EBP) alpha and beta . Negative_regulation TNF NFKB1 11571308 882350 The antigen presenting capacity of [TNF-alpha] stimulated CD34 ( + ) cells was strongly *inhibited* by ICOSIg fusion proteins or by inhibition . Negative_regulation TNF NFKB1 11576850 865179 TNF was measured by an enzyme linked immunosorbent assay after 8 h , and induction by electrophoretic mobility shift assays ( EMSA ) after 2 h. DMXAA ( 800 microg/ml ) had no effect alone on TNF production but *augmented* , by up to 4-fold , the ability of bacterial lipopolysaccharide (LPS) to induce [TNF] . Negative_regulation TNF NFKB1 11676830 873541 These results indicate that interferon-gamma and [TNF-alpha] synergistically *induce* keratinocyte apoptosis when concomitant induction of is blocked . Negative_regulation TNF NFKB1 11948689 930241 Conversely , expression of the p65 subunit of *suppressed* [TNF-alpha-] , TRAIL- , and serum deprivation induced cell death . Negative_regulation TNF NFKB1 11991979 938615 Inhibition of [tumor necrosis factor] alpha *induced* activation by the adenovirus E3-10.4/14.5K complex . Negative_regulation TNF NFKB1 12133965 967048 Here we investigate the *role* of mitogen activated protein kinases ( MAPKs ) and in [TNF-alpha] production by human monocytes stimulated with GBS or LPS , used as a positive control . Negative_regulation TNF NFKB1 12174385 974522 sCCK-8 *inhibits* LPS induced [TNF-alpha] mRNA expression by regulating activity in rat PIMs , which is mediated through CCK receptors and inhibiting IkappaB-alpha degradation . Negative_regulation TNF NFKB1 12175093 974551 Ketamine significantly reduced the LPS induced activation and *inhibited* [TNFalpha] production in a dose dependent manner . Negative_regulation TNF NFKB1 12203103 983116 The *role* of in enhancement of [TNF-alpha] production was confirmed in experiments in which MG132 , an inhibitor of NF-kappaB activation , reversed the effect of AdAMP . Negative_regulation TNF NFKB1 12349954 992882 Catalposide , the major iridoid glycoside isolated from the stem bark of Catalpa ovata G. Don ( Bignoniaceae ) , was found to *inhibit* the productions of [tumor necrosis factor-alpha (TNF-alpha)] , interleukin-1beta (IL-1beta) , and interleukin-6 (IL-6) , and the activation of in RAW 264.7 macrophages activated with lipopolysaccharide (LPS) . Negative_regulation TNF NFKB1 12871593 1114132 *Activation* of as well as C/EBPbeta by p40 and inhibition of p40 induced expression of [TNF-alpha] by Deltap65 , a dominant negative mutant of p65 , and DeltaC/EBPbeta , a dominant negative mutant of C/EBPbeta , suggests that p40 induces the expression of TNF-alpha through the activation of NF-kappaB and C/EBPbeta . Negative_regulation TNF NFKB1 14503852 1144632 Astaxanthin also suppressed the serum levels of NO , PGE2 , [TNF-alpha] , and IL-1beta in LPS administrated mice , and *inhibited* activation as well as iNOS promoter activity in RAW264.7 cells stimulated with LPS . Negative_regulation TNF NFKB1 14575704 1156224 *dependent* regulation of [tumor necrosis factor-alpha] gene expression by CpG-oligodeoxynucleotides . Negative_regulation TNF NFKB1 14584760 1159101 Treatment of rats with HES ( 3.75 and 7.5 ml/kg ) prevented LPS induced activation , and *inhibited* , in a dose related manner , LPS induced [TNF-alpha] and CINC expression . Negative_regulation TNF NFKB1 14646597 1173168 is *involved* in the [TNF-alpha] induced inhibition of the differentiation of 3T3-L1 cells by reducing PPARgamma expression . Negative_regulation TNF NFKB1 14736953 1199591 We investigated the *role* of and AP-1 in [tumour necrosis factor alpha (TNF-alpha)] induced monocyte chemoattractant protein 1 ( MCP-1 ) production in cultured human glomerular endothelial cells ( HGEC ) . Negative_regulation TNF NFKB1 15322736 1287025 In vivo treatment with cloricromene ( 2 mg/kg/i.v. ) 30 min before lipopolysaccharide administration reversed the LPS induced loss in tone of the aortic rings , improved their reactivity to phenylephrine , decreased both nitric oxide ( NO ) and [TNF-alpha] serum levels by inhibiting LPS induced inducible NO synthase and TNF-alpha mRNA expression , and interestingly *inhibited* LPS induced activation . Negative_regulation TNF NFKB1 15659838 1350238 p7F also suppressed the serum level of [TNF-alpha] in mice treated with collagen and *inhibited* activation as well as NF-kappaB promoter activity in RAW 264.7 cells stimulated with LPS . Negative_regulation TNF NFKB1 15719215 1416773 The mechanisms involved in the anti-oxidative properties of 15d-PGJ2 in stress involve blockade ( by preventing stress induced IkappaBalpha decrease ) as well as *inhibition* of [TNFalpha] release in stressed animals . Negative_regulation TNF NFKB1 15723831 1396168 *dependent* down-regulation of [tumor necrosis factor] receptor associated proteins contributes to interleukin-1 mediated enhancement of ultraviolet B-induced apoptosis . Negative_regulation TNF NFKB1 15760549 1383239 Glycine could efficiently protect rat liver grafts from ischemia-reperfusion injury by repressing the expression of CD14 and binding activity in Kupffer cells and *inhibiting* the productions of [TNF alpha] and IL-1 . Negative_regulation TNF NFKB1 15901350 1409122 Taken together , the data demonstrate that MEMO has anti-inflammatory and antinociceptive activity , *inhibiting* iNOS , COX-2 and [TNF-alpha] expression by down regulating binding activity . Negative_regulation TNF NFKB1 15938622 1415416 Inhibition of by cobrotoxin *resulted* in reductions in the LPS induced expressions of COX-2 , iNOS , cPLA(2) , IL-4 , and [TNF-alpha] in astrocytes and in COX-2 expression induced by SNP , LPS , and TNF-alpha in astrocytes . Negative_regulation TNF NFKB1 15980040 1465294 Taken together , these data provide compelling evidence for the *role* of signaling in [TNF-alpha] gene expression in heart and highlight the importance of this proinflammatory gene-regulatory pathway as a potential therapeutic target in the management of cytokine induced myocardial dysfunction . Negative_regulation TNF NFKB1 16020286 1432108 Presence of the NF-kappaB inhibitor kamebakaurin in culture medium blocked P. aeruginosa induced activation and *inhibited* IL-6 , IL-8 , and [TNF-alpha] expression and secretion . Negative_regulation TNF NFKB1 16078585 1442530 The results indicated that thalidomide treatment significantly reduced colonic inflammation , suppressed activation , enhanced TNF-alpha mRNA degradation , *inhibited* the synthesis of the [TNF-alpha] , IEN-gamma and increased the production of IL-4 . Negative_regulation TNF NFKB1 16110831 1445339 DATS could downregulate [TNF-alpha] production and *inhibit* activation in lamina propria mononuclear cells of inflammed mucosa , without any effect on the viability of colonic tissue cells . Negative_regulation TNF NFKB1 16288994 1484463 These results suggest that the inhibitory effect of equol on [TNF-alpha] expression is *mediated* , at least in part , by blocking activation and the inhibition of TNF-alpha expression by equol might be involved in its osteoprotective effect . Negative_regulation TNF NFKB1 16365438 1504944 Furthermore , we present evidence that A238L *inhibits* the activation of [TNF-alpha] by modulating , NF-AT , and c-Jun trans activation through a mechanism that involves CREB binding protein/p300 function , because overexpression of these transcriptional coactivators recovers TNF-alpha promoter activity . Negative_regulation TNF NFKB1 16455676 1534321 The aim of the present study is to examine whether this vitamin D inhibition of [TNFalpha] is *mediated* by its major transcription factor , . Negative_regulation TNF NFKB1 16526563 1536135 The production of [TNFalpha] was significantly *inhibited* by cationic decoy complex but not by cationic liposomes/random decoy complex or naked NFkappaB decoy . Negative_regulation TNF NFKB1 16770837 1682195 ADMA ( 30 microM ) significantly increased the activity of NF-kappaB and elevated the levels of ICAM-1 and [TNF-alpha] , and pre-treatment with rosiglitazone ( 10 or 30 microM ) markedly *inhibited* the increased activity of and reduced the elevated levels of TNF-alpha and ICAM-1 induced by ADMA in cultured endothelial cells . Negative_regulation TNF NFKB1 16774932 1672070 PMA selectively causes the degradation of IkappaB kinases ( IKKs ) including IKK-gamma and IKK-beta , and subsequent inhibition of [tumor necrosis factor (TNF)] *induced* IKK and activation in human colon cancer cell line HCT-116 , but not in other gastrointestinal tract cells . Negative_regulation TNF NFKB1 16965747 1616051 QGHXR can protect liver cells by down regulating the expressions of CD14 , TLR(4) and and *inhibiting* [TNF-alpha] expression . Negative_regulation TNF NFKB1 17115116 1709112 Resveratrol , a polyphenolic , natural phytoalexin found with particularly high levels in grape skin and red wine is potent and specific inhibitor of [TNF-alpha] and IL-1beta *induced* activation . Negative_regulation TNF NFKB1 17272828 1733238 The regulation was presumably at the transcriptional level , because mRNA expression for HSL and PLIN was markedly reduced with [TNF-alpha] in the *presence* of inhibition . Negative_regulation TNF NFKB1 17575011 1786114 FF demonstrated very potent glucocorticoid activity in several key pathways downstream of the glucocorticoid receptor (GR) as follows : the transrepression pathway , the transactivation glucocorticoid response element pathway , and *inhibition* of the proinflammatory cytokine [tumor necrosis factor-alpha] . Negative_regulation TNF NFKB1 17592223 1768204 Moderate , acute alcohol consumption or equivalent doses of alcohol in vitro had anti-inflammatory effects on monocyte activation via inhibition of pro-inflammatory genes and activation , *inhibition* of [TNFalpha] production and augmentation of the anti-inflammatory cytokine , IL-10 . Negative_regulation TNF NFKB1 17898021 1849055 Furthermore , the increased synthesis of IL-6 and [TNF-alpha] by anionic pIgA in HMC was significantly diminished ( P < 0.01 ) in the *presence* of NF-kappaB inhibitor pyrrolidine dithiocarbamate and blocking permeable peptides SN50 ( P < 0.01 ) . Negative_regulation TNF NFKB1 17931811 1819685 In lipopolysaccharide (LPS) stimulated RAW264.7 cells , HMCO5 inhibited activation as well as iNOS promoter activity , *inhibited* the secretion of [TNF-alpha] and IL-1beta , and directly inhibited the intracellular accumulation of reactive oxygen species . Negative_regulation TNF NFKB1 17953529 1814631 The mice with colitis treated by AN showed less tissue damage , less MPO activity , less [TNF-alpha] production in colon , and *inhibited* activation in LPMC , compared with those mice with colitis untreated , whereas the mice with colitis treated by CHD showed the worst tissue damage , the highest MPO activity , the highest TNF-alpha level , and enlarged NF-kappaB activation in LPMC . Negative_regulation TNF NFKB1 18385389 1925574 MT downregulated the [TNF-alpha] mRNA level , and PDTC *inhibited* the increases in both translocation and TNF-alpha mRNA . Negative_regulation TNF NFKB1 18559343 1952549 OxPAPC inhibited [tumor necrosis factor-alpha] production , IkappaBalpha degradation , p38 MAPK phosphorylation , and dependent reporter activation *induced* by stimulants of TLR2 and TLR4 ( Pam3CSK4 and LPS ) but not by stimulants of other TLRs ( poly ( I.C ) , flagellin , loxoribine , single stranded RNA , or CpG DNA ) in macrophages and HEK-293 cells transfected with respective TLRs and significantly reduced inflammatory responses in mice injected subcutaneously or intraperitoneally with Pam3CSK4 . Negative_regulation TNF NFKB1 18645721 1942284 Human lung epithelial cells ( A549 ) were stimulated with [tumor necrosis factor (TNF)-alpha] in the *presence* or absence of specific inhibitors of or the p38 MAP kinase and exposed to chlorobenzene using an air-liquid cell culture system . Negative_regulation TNF NFKB1 19023660 2035109 This study examines the *role* of in the regulation of [TNFalpha] production by morphine in microglia . Negative_regulation TNF NFKB1 19043204 1998812 Moreover , [TNF-alpha] production was *prevented* by and mitogen activated protein kinase (MAPK) inhibitors . Negative_regulation TNF NFKB1 19086324 2000267 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 MAPK and activities , and then [TNF-alpha] overexpression , thus alleviating the inflammatory reaction . Negative_regulation TNF NFKB1 19182383 2033246 Mangiferin also reduced acetylcholine and [tumor necrosis factor (TNF)-alpha] levels induced by scopolamine in mice brain ( p < 0.05 ) and *inhibited* activation in scopolamine or TNF-alpha stimulated BV-2 microglial cells . Negative_regulation TNF NFKB1 19220017 2179618 We describe herein the synthesis and biological activity of a series of imidazoline based scaffolds as potent inhibitors of *mediated* gene transcription in cell culture as well as inhibitors of [TNF-alpha] and IL-6 production in interleukin 1 beta (IL-1beta) stimulated human blood . Negative_regulation TNF NFKB1 19349680 2057594 Hemin further upregulated the expression of HO-1 mRNA , decreased activity drastically , and *inhibited* the serum levels of [TNF-alpha] and IL-6 significantly ( P < 0.05 ) . Negative_regulation TNF NFKB1 19616538 2124169 Ghrelin also significantly suppressed interleukin-1beta , [tumor necrosis factor-alpha] , and endothelin-l mRNA expression , and *inhibited* activation . Negative_regulation TNF NFKB1 19640904 2138163 PPAR-alpha reduced the *induced* overexpression of [TNF-alpha] and apoptosis in cultured kidney cells . Negative_regulation TNF NFKB1 19748795 2153101 ZD 7155 also reduced the mRNA expression of [TNF-alpha] and IL-1 beta , *inhibited* the activation of and AP-1 , and improved lung histopathology . Negative_regulation TNF NFKB1 20030669 2287267 In the ARDS model , vitamin K3 also suppressed the LPS induced increase in the serum [TNF-alpha] level and *inhibited* the LPS evoked nuclear translocation of in lung tissue . Negative_regulation TNF NFKB1 20356387 2255196 Moreover , we explored the mechanism governing the expression of ATX in hepatoma cells and established a critical *role* of in basal and [TNF-alpha] induced ATX expression . Negative_regulation TNF NFKB1 20451670 2288421 Meanwhile , HES could significantly reduce [TNF-alpha] , IL-6 , and ICAM-1 mRNA , *inhibit* activation , and down-regulate TLR2 and TLR4 expression in the brain . Negative_regulation TNF NFKB1 7608567 311954 Transcriptional *activation* of the human [TNF-alpha] promoter by superantigen in human monocytic cells : role of . Negative_regulation TNF NFKB1 7635431 317117 Using primary cultures of rat Kupffer cells the *role* of and activator protein 1 (AP-1) in the expression of the [tumor necrosis factor-alpha (TNF-alpha)] gene by lipopolysaccharide (LPS) was investigated . Negative_regulation TNF NFKB1 7913275 262069 HIV-1 expression was activated from J delta K cells by treatment with phorbol myristate acetate ( PMA ) , sodium butyrate ( NaB ) , or hexamethylene bisacetamide ( HMBA ) , but not tumor necrosis factor alpha (TNF-alpha) , confirming the *role* of in mediating [TNF-alpha] induction of HIV transcription . Negative_regulation TNF NFKB1 8598494 350740 We demonstrate that IL-1 and [TNF] *induce* rapid nuclear translocation of p65(RelA) in T cell clones , whereas TCR induced activation in Th1 cells is delayed and may be longer in duration . Negative_regulation TNF NFKB1 9003392 404832 Exposure of rat Kupffer cells to a physiologically relevant concentration of lipopolysaccharide ( 10 ng/ml ) activated NF-kappa B within 1 h and induced the release of TNF-alpha over 5 h. Cellular glutathione content remained unchanged after lipopolysaccharide exposure , but both glutathione monoethyl ester and N-acetyl-L-cysteine increased cellular glutathione levels , blocked activation and *inhibited* the release of [TNF-alpha] . Negative_regulation TNF NFKB1 9079634 420538 *Role* of in [tumor necrosis factor-alpha] and interleukin-1beta regulation . Negative_regulation TNF NFKB1 9415036 471901 Tosylphenylalanine chloromethyl ketone inhibits [TNF-alpha] mRNA synthesis in the *presence* of activated in RAW 264.7 macrophages . Negative_regulation TNF NFKB1 9415036 471903 Our results show that TPCK inhibits LPS induced [TNF-alpha] mRNA synthesis in the *presence* of activated and suggests that mechanisms other than NF-kappa B activation are involved in the transcriptional regulation of the TNF-alpha gene . Negative_regulation TNF NFKB1 9486215 488318 In the present study , electrophoretic mobility shift assays ( EM-SAs ) and pyrrolidine dithiocarbamate ( PDTC ) , an inhibitor of NF-kappa B activation , were utilized to determine the *role* of activation in TPA and [TNF-alpha] inhibition of the surfactant proteins in NCI-H441 cells . Negative_regulation TNF NFKB1 9486215 488330 The effects of PDTC and PTX on NF-kappa B and the surfactant proteins suggest that activation does not *mediate* TPA or [TNF-alpha] inhibition of SP-A and SP-B mRNA accumulation . Negative_regulation TNF NFKB1 9581775 503481 The protective *role* of in blocking [TNFalpha-] and HIV-1 induced apoptosis was supported by studies in Jurkat T cells engineered to express IkappaB alpha repressor mutants ( TD-IkappaB ) under the control of a tetracycline-responsive promoter . Negative_regulation TNF NFKB1 9802878 544024 In the present study , which uses mice with genetic deletions of the proteins of NF-kappaB complex , we provide data demonstrating that increased expression of the p50 subunit of directly *results* in the downregulation of LPS induced [TNF] production . Negative_regulation TNF NFKBIA 10454561 637967 In the present study , we demonstrate that expression of *blocked* phorbol myristate acetate-phytohemagglutinin or [tumor necrosis factor] alpha induced IkappaBalpha gene transcription and abolished NF-kappaB DNA binding activity , due to the continued cytoplasmic sequestration of RelA ( p65 ) by TD-IkappaBalpha . Negative_regulation TNF NFKBIA 10959811 726326 Pretreatment of rats with DDB prevented LPS induced hepatic degradation and the resultant NF-kappaB activation , and *inhibited* the LPS induced plasma TNF-alpha protein and hepatic [TNF-alpha] mRNA expression in a dose dependent manner . Negative_regulation TNF NFKBIA 11238593 790755 [TNF] stimulation *induced* similar levels of phosphorylation and degradation of in embryonic fibroblasts from either wild-type or NIK-mutant mice . Negative_regulation TNF NFKBIA 12175093 974548 LPS stimulation of rat PBMC *increased* [TNFalpha] production and NFkappaB activation , with corresponding loss of . Negative_regulation TNF NFKBIA 12578813 1058231 overexpression or ALLN treatment of burn trauma prevented NF-kappaB activation in cardiac tissue , *prevented* cardiomyocyte secretion of [TNF-alpha] , and ablated burn mediated cardiac contractile dysfunction . Negative_regulation TNF NFKBIA 15766401 1383655 The results indicated that deltaN may inhibit the activation of NF-kappaB and *reduce* the release of [TNF-alpha] and IL-6 , suggesting the recombinant deltaN IkappaBalpha adenovirus may be used for anti-inflammatory therapy . Negative_regulation TNF NFKBIA 16371367 1519653 Regulation of nuclear translocation of HDAC3 by is *required* for [tumor necrosis factor] inhibition of peroxisome proliferator activated receptor gamma function . Negative_regulation TNF NFKBIA 16571608 1611831 The spontaneous production of macrophage produced pro-inflammatory cytokines varied : [TNFalpha] was modestly *inhibited* by overexpression , but interleukin (IL)-1 was unaffected . Negative_regulation TNF NFKBIA 17267205 1710610 The present results demonstrate that 1,25 ( OH ) ( 2 ) D ( 3 ) and 1,24 ( OH ) ( 2 ) D ( 2 ) *inhibit* [TNFalpha] expression in macrophages , by increasing and decreasing NFkappaB activity . Negative_regulation TNF NFKBIA 18235000 1864342 [TNF-alpha] *induced* the phosphorylation and downregulation of and the translocation of the p65 subunit of NF-kappaB to the nucleus . Negative_regulation TNF NFKBIA 18559343 1952550 OxPAPC *inhibited* [tumor necrosis factor-alpha] production , degradation , p38 MAPK phosphorylation , and NF-kappaB dependent reporter activation induced by stimulants of TLR2 and TLR4 ( Pam3CSK4 and LPS ) but not by stimulants of other TLRs ( poly ( I.C ) , flagellin , loxoribine , single stranded RNA , or CpG DNA ) in macrophages and HEK-293 cells transfected with respective TLRs and significantly reduced inflammatory responses in mice injected subcutaneously or intraperitoneally with Pam3CSK4 . Negative_regulation TNF NFKBIA 19032979 2022944 To elucidate potential molecular mechanisms of SCYA2 increase , we examined genes in the nuclear factor-kappa B (NF-kappaB) signaling cascade including [tumor necrosis factor-alpha (TNF-alpha)] , interleukin-1beta (IL-1beta) and *inhibitor* of kappa B alpha ( ) in choroid tissue . Negative_regulation TNF NFKBIA 19656901 2143590 LPS-tolerant cells showed increased expression of negative regulators Toll interacting protein (Tollip) , suppressor of cytokine signaling (SOCS)-1 , IL-1R associated kinase-M , and SHIP-1 , which correlated with reduced p38 phosphorylation , degradation , and *inhibited* expression of [TNF-alpha] , IL-6 , and IL-8 . Negative_regulation TNF NFKBIA 20696864 2312099 Surprisingly , however , whereas mRNA expression and cellular release of [TNF-alpha] , the beta form of pro-IL-1 ( IL-1beta ) , and IL-6 were *inhibited* by the leptomycin B-induced nuclear , IL-8 mRNA expression and cellular release were not significantly affected . Negative_regulation TNF NFKBIA 8709193 376506 Coexpression of *inhibited* [Tat-TNF-alpha] activation of HIV LTR in a dose dependent manner . Negative_regulation TNF NFKBIA 9872676 556921 We hypothesized that IL-10 *prevents* human monocyte NF-kappaB activation and resultant [TNF-alpha] production by stabilization of . Negative_regulation TNF NFKBIB 20740013 2313582 Surprisingly , absence of *results* in a dramatic reduction of [TNF-alpha] in response to LPS even though activation of NF-kappaB is normal . Negative_regulation TNF NFKBIB 8663191 368410 We conclude that [TNF] causes persistent activation of NF-kappaB in human EC and that this may *result* from sustained reductions in levels . Negative_regulation TNF NFKBID 15749903 1379779 Furthermore , small interference RNA mediated reduction in expression in RAW264.7 cells *resulted* in increased LPS induced production of IL-6 , but not [TNF-alpha] . Negative_regulation TNF NFKBIZ 15618216 1375549 In contrast , [tumor necrosis factor-alpha] production was *inhibited* by expression of , highlighting the dual functions of this molecule . Negative_regulation TNF NGF 10201958 605714 We have observed that at doses as low as 10 ng/ml will induce IL-6 production and *inhibit* [TNF-alpha] release from rat peritoneal mast cells in the presence of lysophosphatidylserine as a cofactor . Negative_regulation TNF NGF 1850261 155545 T2 binding of [TNF] is not *inhibited* by , although the nerve growth factor receptor is also a member of the same family , nor by nine other recombinant cytokines . Negative_regulation TNF NKX2-1 11053014 745133 Taken together these data indicated that in NCI-H441 cells 1 ) [TNF-alpha] inhibition of SP-B promoter activity may be *caused* by decreased binding activities of TTF-1 and HNF-3 elements , 2 ) the decreased binding activities of and HNF-3 alpha are not due to decreased nuclear levels of the proteins , and 3 ) okadaic acid-sensitive phosphatases may be involved in mediating TNF-alpha inhibition of SP-B promoter activity . Negative_regulation TNF NLRP3 22711073 2621311 *Role* of and CARD8 in the regulation of [TNF-a] induced IL-1ß release in vascular smooth muscle cells . Negative_regulation TNF NMS 24355430 2899792 *inhibited* the production of IFN-? and [TNF-a] but enhanced the release of TGF-ß1 by IL-2/IL-12 activated NK cells . Negative_regulation TNF NOD1 24382222 2883542 Oleate/palmitate mixture activated the NF-?B pathway and induced interleukin-6 , [tumor necrosis factor-a] , and monocyte chemoattractant protein-1 mRNA expressions in adipocytes from mice deficient in Toll-like receptor 4 , and these effects were *blocked* by siRNA targeting . Negative_regulation TNF NOD2 19094116 2036075 CD patients have impaired GM-CSF secretion via NOD2 dependent and -independent pathways and display an impaired *dependent* down-regulation of [TNF-alpha] secretion . Negative_regulation TNF NOD2 21396483 2453294 Artesunate not only inhibited [TNF-a] and IL-6 release but also *inhibited* mRNA and protein expressions of TLR2 and , two important receptors , in murine peritoneal macrophages stimulated with heat killed WHO-2 , further demonstrating anti-inflammatory effect of artesunate was related to the inhibition of TLR2- and Nod2 mediated proinflammatory cytokines . Negative_regulation TNF NOD2 24228579 2868703 Baicalin is able to specifically inhibit the expression of , *inhibit* the expression of inflammatory factors IL-1beta , IL-6 and [TNF-alpha] , and thereby reducing the injury of the tissue cells during the course of disease . Negative_regulation TNF NOS1 11414678 828986 The ability of Japanese encephalitis virus ( JEV ) and JEV induced macrophage derived factor ( MDF ) to modulate nitric oxide synthase (NOS) activity in brain and [tumor necrosis factor-alpha (TNF-alpha)] and the possible antiviral *role* of during JEV infection were investigated . Negative_regulation TNF NOS1 11850061 912930 Inhibition of the inducible form of ( iNOS ) by L-NIL did not affect LPS toxicity , but *increased* the LPS induced levels of both [TNF-alpha] and IL-1beta . Negative_regulation TNF NOS1 11854621 914026 Further , inhibition of by L-NAME *potentiated* the [TNF-alpha] response , suggesting a protective role for endogenously produced NO in these two cell lines . Negative_regulation TNF NOS1 17466955 1761294 *Role* of neuronal in lipopolysaccharide induced [tumor necrosis factor-alpha] expression in neonatal mouse cardiomyocytes . Negative_regulation TNF NOS1 17466955 1761303 However , the *role* of in LPS induced [TNF-alpha] expression is not known . Negative_regulation TNF NOS1 17466955 1761306 *inhibits* LPS induced [TNF-alpha] expression in cardiomyocytes and improves cardiac function in endotoxemia . Negative_regulation TNF NOS1 19939906 2319461 Sesamol inhibited serum [tumor necrosis factor (TNF)-a] , interleukin (IL)-1ß and nitrite production in LPS treated mice , and *inhibited* LPS induced inducible expression in mouse leukocytes . Negative_regulation TNF NOS1 20237583 2223930 Interestingly , endothelial nitric oxide synthase (eNOS) promotes TNF-alpha expression by enhancing p38 MAPK activation , whereas *inhibits* [TNF-alpha] production by reducing Ca2+ dependent ERK1/2 activity . Negative_regulation TNF NOS1 7520469 266308 In vitro experiments indicated that inhibition by N-nitro-L-arginine methyl ester ( L-NAME ) *enhanced* IFN-gamma and [TNF] production by splenocytes in response to SEB . Negative_regulation TNF NOS2 10224371 610183 In addition , Ro 31-8220 ( a PKC inhibitor ) inhibited OX8 induced upregulation , NO and IL-1beta production , but did not *inhibit* [TNF-alpha] production . Negative_regulation TNF NOS2 11850061 912931 Inhibition of the inducible form of ( iNOS ) by L-NIL did not affect LPS toxicity , but *increased* the LPS induced levels of both [TNF-alpha] and IL-1beta . Negative_regulation TNF NOS2 11854621 914027 Further , inhibition of by L-NAME *potentiated* the [TNF-alpha] response , suggesting a protective role for endogenously produced NO in these two cell lines . Negative_regulation TNF NOS2 14503852 1144633 Astaxanthin also suppressed the serum levels of NO , PGE2 , [TNF-alpha] , and IL-1beta in LPS administrated mice , and *inhibited* NF-kappaB activation as well as promoter activity in RAW264.7 cells stimulated with LPS . Negative_regulation TNF NOS2 17049356 1724419 Application of CTS for only 1 or 2h during a 24h incubation with IL-1beta was sufficient to *inhibit* IL-1beta induced upregulation of [TNF-alpha] , TNFR2 , and . Negative_regulation TNF NOS2 17207792 1695789 Taken together , our data indicate that the anti-inflammatory and antinociceptive properties of siegeskaurolic acid may be due to , COX-2 and [TNF-alpha] *inhibition* via the down-regulation of NF-kappaB binding activity . Negative_regulation TNF NOS2 17466955 1761295 *Role* of neuronal in lipopolysaccharide induced [tumor necrosis factor-alpha] expression in neonatal mouse cardiomyocytes . Negative_regulation TNF NOS2 17632098 1780008 In lipopolysaccharide from Escherichia coli ( LPS ) -treated RAW 264.7 macrophages , NCX 6560 reduced expression and dimer assembly more efficiently than atorvastatin and *inhibited* nitrite accumulation ( IC ( 50 ) =6.7+/-1.6 microM ) and [TNFalpha] release . Negative_regulation TNF NOS2 17931811 1819686 In lipopolysaccharide (LPS) stimulated RAW264.7 cells , HMCO5 inhibited NF-kappaB activation as well as promoter activity , *inhibited* the secretion of [TNF-alpha] and IL-1beta , and directly inhibited the intracellular accumulation of reactive oxygen species . Negative_regulation TNF NOS2 19939906 2319462 Sesamol inhibited serum [tumor necrosis factor (TNF)-a] , interleukin (IL)-1ß and nitrite production in LPS treated mice , and *inhibited* LPS induced inducible expression in mouse leukocytes . Negative_regulation TNF NOS2 22303922 2668270 SPEE treatment significantly inhibited the LPS induced production of NO , prostaglandin E ( 2 ) , interleukin-6 , and [tumor necrosis factor-a] and *inhibited* the expression of and COX-2 via attenuation of NF-?B p65 expression . Negative_regulation TNF NOS2 22953812 2667615 Fucosterol suppressed the expressions of , tumour necrosis factor-a (TNF-a) , and interleukin-6 (IL-6) by downregulating their transcriptions , and subsequently *inhibited* the productions of nitric oxide , [TNF-a] , and IL-6 . Negative_regulation TNF NOS2 23243434 2708701 In addition , TSAV attenuated the serum [TNF-a] and IL-6 levels and *inhibited* the serum and NO levels . Negative_regulation TNF NOS2 23877917 2830191 Consistent with these observations , echinocystic acid concentration-dependently inhibited lipopolysaccharide induced inducible nitric oxide synthase expression at the protein level and inducible nitric oxide synthase , [tumor necrosis factor-a] , and interleukin-6 expression at the mRNA level , and *inhibited* lipopolysaccharide induced promoter binding activity . Negative_regulation TNF NOS2 24456333 2907466 Chronic treatment with pioglitazone exerts an enhanced gastroprotective effect on the stomach ulcers of cholestatic rats compared to sham rats probably due to constitutive NOS induction and/or *inhibition* and attenuating release of [TNF-a] . Negative_regulation TNF NOS2 7759887 307852 Synergy between IFN-gamma and taxol was mainly dependent on taxol induced TNF-alpha secretion because not only the increase of gene expression by rIFN-gamma plus taxol was associated with the increased expression of TNF-alpha gene but also taxol induced NO production was decreased by the treatment of anti-murine TNF-alpha neutralizing Abs. STSN and polymyxin B potently *inhibited* taxol induced [TNF-alpha] secretion and TNF-alpha gene expression as well as iNOS gene expression by rIFN-gamma plus taxol . Negative_regulation TNF NOS2 9168934 432676 Cisplatin induced [tumor necrosis factor-alpha (TNF-alpha)] mRNA expression , and an anti-TNF-alpha neutralizing antibody *inhibited* the induction of expression by a combination of cisplatin and IFN-gamma in NB-39-nu cells . Negative_regulation TNF NOS2 9691088 523113 Inhibition of activity by aminoguanidine also *attenuates* [TNF] + LPS + IFN-gamma induced inhibition of insulin secretion by human islets . Negative_regulation TNF NOS3 11850061 912932 Inhibition of the inducible form of ( iNOS ) by L-NIL did not affect LPS toxicity , but *increased* the LPS induced levels of both [TNF-alpha] and IL-1beta . Negative_regulation TNF NOS3 11854621 914028 Further , inhibition of by L-NAME *potentiated* the [TNF-alpha] response , suggesting a protective role for endogenously produced NO in these two cell lines . Negative_regulation TNF NOS3 12506117 1056922 The purpose of this study was to investigate the *role* of , cAMP , and p38 MAPK in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Negative_regulation TNF NOS3 14555463 1185979 [TNF-alpha] *induces* a decrease in promoter activity . Negative_regulation TNF NOS3 17466955 1761296 *Role* of neuronal in lipopolysaccharide induced [tumor necrosis factor-alpha] expression in neonatal mouse cardiomyocytes . Negative_regulation TNF NOS3 18574745 1930113 In the non-parenchymal cell fraction , gene expression was preserved and gene expression of [TNF-alpha] was *blocked* after MDP but not after GdCl ( 3 ) application prior to LPS shock . Negative_regulation TNF NOS3 19548191 2162487 The cardiovascular protective effect of RCLE seems to be due to an interplay of different factors : COX pathway activation , [TNF-alpha] *inhibition* , activation , and free radical and ROS scavenging . Negative_regulation TNF NOS3 19939906 2319463 Sesamol inhibited serum [tumor necrosis factor (TNF)-a] , interleukin (IL)-1ß and nitrite production in LPS treated mice , and *inhibited* LPS induced inducible expression in mouse leukocytes . Negative_regulation TNF NOX1 15390122 1304808 Expression of IL-1beta , [TNF-alpha] , and iNOS in ganglioside treated cells was significantly reduced in the *presence* of inhibitors of PKC ( GF109203X , Go6976 , Ro31-8220 , and rottlerin ) and ( diphenyleneiodonium chloride [ DPI ] ) . Negative_regulation TNF NOX1 19450605 2096907 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated expression and activity , decreased phosphorylation of ERK1/2/p38 MAPK and *inhibited* cardiac [TNF-alpha] expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation TNF NOX3 15390122 1304809 Expression of IL-1beta , [TNF-alpha] , and iNOS in ganglioside treated cells was significantly *reduced* in the presence of inhibitors of PKC ( GF109203X , Go6976 , Ro31-8220 , and rottlerin ) and ( diphenyleneiodonium chloride [ DPI ] ) . Negative_regulation TNF NOX3 19450605 2096908 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated expression and activity , decreased phosphorylation of ERK1/2/p38 MAPK and *inhibited* cardiac [TNF-alpha] expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation TNF NOX4 15390122 1304810 Expression of IL-1beta , [TNF-alpha] , and iNOS in ganglioside treated cells was significantly reduced in the *presence* of inhibitors of PKC ( GF109203X , Go6976 , Ro31-8220 , and rottlerin ) and ( diphenyleneiodonium chloride [ DPI ] ) . Negative_regulation TNF NOX4 19450605 2096909 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated expression and activity , decreased phosphorylation of ERK1/2/p38 MAPK and *inhibited* cardiac [TNF-alpha] expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation TNF NOX5 15390122 1304807 Expression of IL-1beta , [TNF-alpha] , and iNOS in ganglioside treated cells was significantly *reduced* in the presence of inhibitors of PKC ( GF109203X , Go6976 , Ro31-8220 , and rottlerin ) and ( diphenyleneiodonium chloride [ DPI ] ) . Negative_regulation TNF NOX5 19450605 2096892 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated expression and activity , decreased phosphorylation of ERK1/2/p38 MAPK and *inhibited* cardiac [TNF-alpha] expression induced by LPS , suggesting an important role of Rac1 and estrogen in LPS stimulated TNF-alpha expression in the heart . Negative_regulation TNF NPPA 10861050 705135 To investigate the underlying mechanism of mediated [TNF-alpha] *inhibition* , Northern blot was performed . Negative_regulation TNF NPPA 10861050 705137 significantly *attenuated* production of [TNF-alpha] and IL-1beta without affecting production of IL-10 and IL-1ra . Negative_regulation TNF NPPA 11257311 794437 Human ( 99-126 ) and a specific p38 MAP kinase inhibitor SB203580 *inhibited* the IFN-gamma induced [TNF-alpha] production in a dose dependent manner without affecting NO production . Negative_regulation TNF NPPA 11890659 894240 The relevance of these findings on a regulatory role for ANP on TNFalpha in humans was shown by the fact that significantly *reduces* the release of [TNFalpha] in whole human blood . Negative_regulation TNF NPPA 12022755 943293 significantly *reduced* lipopolysaccharide (LPS) induced [tumor necrosis factor alpha (TNFalpha)] secretion , paralleled by an increased cell associated TNFalpha . Negative_regulation TNF NPPA 12022755 943297 *reduced* [TNFalpha] release possibly by influencing post-translational processing of TNFalpha in LPS activated KCs . Negative_regulation TNF NPS 23419643 2748915 The in vitro and in vivo gene knockdown measurement showed that siMap4k4 loaded GTC/TPP effectively *inhibited* [TNF-a] production , which remarkably outperformed siMap4k4 loaded TC/TPP NPs . Negative_regulation TNF NPS 23768781 2802057 Moreover , significantly *suppressed* the expression of pro-inflammatory cytokines [TNF-a] and IL-8 ; Negative_regulation TNF NPY 25206918 2958171 These results suggest that *prevents* excessive production of interleukin-1ß and [tumor necrosis factor-a] by inhibiting microglial reactivity . Negative_regulation TNF NPY4R 10565609 567413 The src family-selective tyrosine kinase inhibitor *blocks* LPS and IFN-gamma mediated [TNF] and iNOS production in murine macrophages . Negative_regulation TNF NPY4R 10811015 692819 Furthermore , the highly src-family selective pyrazolopyrimidine inhibitor also *blocks* ceramide induced iNOS and [TNF] production in RAW 264.7 cells . Negative_regulation TNF NPY4R 17982091 1821041 *inhibited* LPS induced increases in total protein content in bronchoalveolar lavage fluid , neutrophil recruitment , and increases in the production or activity of [TNF-alpha] and matrix metalloproteinase-9 . Negative_regulation TNF NPY6R 16160917 1456109 Further , the Src inhibitor *inhibited* the release of [TNF-alpha] but enhanced IL-10 release , suggesting the differential regulation of Src kinase in upstream signaling . Negative_regulation TNF NPY6R 17875324 1843340 Here we show that the pyrazolo pyrimidine compound , a selective inhibitor of Src family kinases (SFK) , can *inhibit* LPS induced [TNF] production as well as a number of other inflammatory cytokines . Negative_regulation TNF NPY6R 20100830 2219266 Transient expression of either VCP/p97 or was *sufficient* to elevate levels of the dual specificity phosphatase DUSP1 , reduce p38 MAPK activation , and suppress [tumor necrosis factor-alpha] release . Negative_regulation TNF NQO1 16682409 1584040 The purpose of our study was to determine the *role* of in [TNF] cell signaling by using keratinocytes derived from wild-type and NQO1 gene deleted mice . Negative_regulation TNF NR3C1 19281808 2063744 Moreover , pharmacological inhibition of function by its antagonist ( RU486 ) *inhibited* pioglitazone mediated downregulation of [TNF-alpha] and IL-1beta gene expression confirming involvement of glucocorticoid receptor in pioglitazone mediated ulcer healing . Negative_regulation TNF NR5A2 15684064 1370857 Reciprocally , decreased expression in Lrh-1+/- mice *attenuates* [TNF-alpha] expression . Negative_regulation TNF NTF3 14505339 1144783 In this study , pre-treatment of a mouse microglial cell line , BV2 , with NT-3 for 24 h indicated that *reduced* the inducible form of NO synthase (iNOS) , NO , and [TNF-alpha] in BV2 stimulated with lipopolysaccharide (LPS) . Negative_regulation TNF NUP153 8468478 216116 These observations , coupled with the finding that 15669 does not *inhibit* endotoxin induced [TNF] release suggest that inhibition of leukocyte sequestration can increase survival after endotoxin challenge , and that NPC 15669 or antibodies to Mac-1 may represent effective therapies for gram negative sepsis and shock . Negative_regulation TNF NUP210 8468478 216115 These observations , coupled with the finding that 15669 does not *inhibit* endotoxin induced [TNF] release suggest that inhibition of leukocyte sequestration can increase survival after endotoxin challenge , and that NPC 15669 or antibodies to Mac-1 may represent effective therapies for gram negative sepsis and shock . Negative_regulation TNF NUP214 8468478 216117 These observations , coupled with the finding that 15669 does not *inhibit* endotoxin induced [TNF] release suggest that inhibition of leukocyte sequestration can increase survival after endotoxin challenge , and that NPC 15669 or antibodies to Mac-1 may represent effective therapies for gram negative sepsis and shock . Negative_regulation TNF NUP43 10725745 677654 Phosphorylation of and p44 MAPKs , which can be prevented by a mitogen activated protein/extracellular signal related kinase kinase-1 inhibitor , peaks by 15-20 min and largely disappears by 40 min . IL-11 does not *activate* NF-kappaB nor does it inhibit NF-kappaB activation by [TNF] . Negative_regulation TNF NUP43 11134043 794927 Phosphorylation of correlated with an increase of activity , and [tumor necrosis factor-alpha] levels were significantly *reduced* by addition of inhibitors of p42/44 and p38 , PD 98059 and SB 203580 , respectively . Negative_regulation TNF NUP43 16946004 1639275 Finally , the blocking of MAPK activation *prevented* [TNFalpha] inhibition of FSH dependent increases in P450AROM and inhibin alpha-subunit mRNA levels , thus indicating that p44/42 MAPK mediated ICER expression may be accountable for the effects of TNFalpha on the expression of both proteins . Negative_regulation TNF NUP62 8468478 216118 These observations , coupled with the finding that 15669 does not *inhibit* endotoxin induced [TNF] release suggest that inhibition of leukocyte sequestration can increase survival after endotoxin challenge , and that NPC 15669 or antibodies to Mac-1 may represent effective therapies for gram negative sepsis and shock . Negative_regulation TNF OATP1 15860642 1464962 [TNF-alpha] *induces* a sustained decrease in Ntcp , , and Bsep mRNA expression but exerts only transient [ multidrug resistance associated protein 2 ( Mrp2 ) ] or no effects ( Mrp3 ) on Mrps . Negative_regulation TNF OCLN 23538493 2788577 In addition , [TNF-a] *induced* a downregulation of claudin-1 , claudin-2 , claudin-4 , and as well as activation of phosphatidylinositol 3-kinase signaling in T-84 but not Caco-2 cells , which was reversed by adalimumab . Negative_regulation TNF ODC1 18177935 1894960 Meanwhile conventional expression of *represses* [tumor necrosis factor-alpha (TNF-alpha)] expression and nuclear factor-kappaB (NF-kappaB) activation as well as MMP-9 enzyme activity . Negative_regulation TNF ODC1 18187158 1863105 In our previous studies , overexpression *prevented* [tumor necrosis factor alpha (TNF-alpha)-] and methotrexate induced apoptosis via reduction of ROS . Negative_regulation TNF OMP 12414158 1011000 It is likely that the *induced* effect on [TNF-alpha] production assists bacterial evasion of antimicrobial defences at different levels . Negative_regulation TNF OPA1 10374812 623162 Opposite to IFN-gamma , the lipid prostaglandin E2 ( PGE2 ) enhanced the LPS induced production of IL-10 and *inhibited* that of [TNF] . Negative_regulation TNF OPN1LW 23297421 2746114 [TNF] , acting via NF-?B , did not change the levels of CREB , Sp1 , or Egr-1 binding to the Gas promoter , but it *induced* a significant reduction in the level of . Negative_regulation TNF OPN1MW 21362471 2415776 significantly reduced the extent of liver inflammation , oxidative/nitrative stress , and cell death and also *attenuated* the bacterial endotoxin triggered NF-?B activation and [TNF-a] production in isolated Kupffer cells , likewise the adhesion molecule expression in primary human liver sinusoidal endothelial cells stimulated with TNF-a and attachment of human neutrophils to the activated endothelium . Negative_regulation TNF OPRM1 18349186 1887043 The was not *involved* in this morphine induced [TNF] inhibition in PBMCs . Negative_regulation TNF OR10A4 23979690 2855799 inhibited CXCL10 production in human blood , and the administration of HP2 significantly *suppressed* the production of Th1 cytokines , such as IL-2 , IFN-? , and [TNF-a] , in spleen cells isolated from mice . Negative_regulation TNF OSM 21854541 2599184 In the murine dorsal air pouch model of inflammation , *reduced* the expression of the pro-inflammatory cytokines IL-1ß and [TNF-a] in lining tissues , and their presence in the cavity . Negative_regulation TNF OXA1L 22083716 2540810 Purified recombinant , HSA-shTNFRI and HSA-shTNFRII could *block* the cytolytic activity of [TNF-a] in L929 cells , and the fusion at N-terminus of shTNFRI could result in larger degree of activity decline than that at the C-terminus . Negative_regulation TNF P2RY14 22872320 2715688 As for the mechanisms , the inhibition of receptors *resulted* in the release of [tumor necrosis factor (TNF)-a] which then acted on astrocytes to induce MMP-9 . Negative_regulation TNF P4HB 18475579 290010 The chemotactic activity of the [TNFalpha] 36-62 peptide on PMN , was *inhibited* by Htr-7b , Utr-1 and soluble receptor , which shows that the peptide possessed the ability to induce chemotaxis through the TNF receptors . Negative_regulation TNF P4HB 18680601 1979515 Downregulation of in sepsis and its *role* in [tumor necrosis factor-alpha] release . Negative_regulation TNF PAEP 23768781 2802058 Moreover , significantly *suppressed* the expression of pro-inflammatory cytokines [TNF-a] and IL-8 ; Negative_regulation TNF PAEP 7600193 311517 In an effort to determine the contribution of these two agents to the induction of the accelerated PCD seen here , mice were randomized to receive either RU-38486 ( 11 beta- [ p- ( dimethylamino ) phenyl ] -17 beta-hydroxy-17- ( 1-propynyl ) estra-4,9-dien-3-one ( Mifepristone ) ; a steroid receptor blocker ) , ( rsTNF-R1)2 (a [TNF] *inhibitor* ) immediately following CLP . Negative_regulation TNF PAF1 1873355 165232 Further , the *role* of released in response to a challenge with LPS in the regulation of [TNF] and IL-6 production was investigated . Negative_regulation TNF PAF1 8514698 221947 Repeated dosing also *resulted* in sustained increased serum [tumor necrosis factor-alpha] levels ( 1,610 +/- 470 pg/ml , P < 0.01 ) and further exacerbation of the leukopenia ( -68 +/- 6 % , P < 0.01 ) and thrombocytopenia ( -65 +/- 8 % , P < 0.01 ) . Negative_regulation TNF PAF1 9403541 469605 Furthermore , inhibiting production with AACOCF3 , or manoalide , also *inhibited* LPS induced Mphi [TNF] mRNA expression . Negative_regulation TNF PAM 20844955 2401452 IAP-KO whole-blood stimulation with LPS and *resulted* in increased IL-6 and [tumor necrosis factor (TNF)-alpha] secretion compared with WT . Negative_regulation TNF PARP1 18996291 1983853 Activation and overexpression of in circulating mononuclear cells *promote* [TNF-alpha] and IL-6 expression in patients with unstable angina . Negative_regulation TNF PARP1 19765544 2147392 Minocycline repressed the expression of [TNF-alpha] , IL-1beta , and iNOS , decreased the apoptotic index , and *inhibited* ( PARP-1 ) activity in the mouse small intestine . Negative_regulation TNF PARP1 9639400 514035 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Negative_regulation TNF PARP10 9639400 514030 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Negative_regulation TNF PARP11 9639400 514027 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Negative_regulation TNF PARP12 9639400 514028 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Negative_regulation TNF PARP14 9639400 514039 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Negative_regulation TNF PARP15 9639400 514033 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Negative_regulation TNF PARP16 9639400 514031 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Negative_regulation TNF PARP2 9639400 514037 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Negative_regulation TNF PARP3 9639400 514038 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Negative_regulation TNF PARP4 9639400 514036 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Negative_regulation TNF PARP6 9639400 514034 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Negative_regulation TNF PARP8 9639400 514032 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Negative_regulation TNF PARP9 9639400 514029 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Negative_regulation TNF PCNA 16387162 1494287 Compared to CsA therapy , increased TRL concentrations did not further inhibit expression , inhibited CD25 expression less on days 1 and 2 and equally high on day 3 , but *inhibited* expression of IL-2 and [TNF-alpha] significantly higher on days 2 and 3 ( P < .05 ) . Negative_regulation TNF PCNA 18929838 1977893 The intragraft expression of [TNF-alpha] and caspase-3 was strikingly promoted in the normal saline treated group and *attenuated* compared to the ALR group . Negative_regulation TNF PCNA 23671449 2785108 Meanwhile , EsA reduced the serum IL-6 and [TNF-a] levels ( p < 0.05 ) , *inhibited* the expression of and promoted the expression of caspase-3 , Fas and FasL in animals of the treated group ( p < 0.05 ) . Negative_regulation TNF PCSK9 17996668 1821718 In mouse model of skin inflammation , *inhibited* phorbol ester induced increase in ear thickness and expression of [tumor necrosis factor-alpha] in the ear of BALB/c mice . Negative_regulation TNF PCSK9 17996668 1821720 Further study demonstrated that the mRNA expression of [tumor necrosis factor-alpha] and adhesion molecules , such as vascular cell adhesion molecule-1 , intercellular adhesion molecule-1 , E-selectin , was also *suppressed* by in the ear of mite extract treated NC/Nga mice . Negative_regulation TNF PCSK9 18721197 1979920 also *suppressed* IL-4 and [TNF-alpha] expression in the ears and mast cell infiltration into the ears in NC/Nga mice . Negative_regulation TNF PDCD1LG2 19729380 2163106 B7-H1 blockade on DSCs strongly *enhanced* T cell cytokine production ( IFN-gamma , [TNF-alpha] and IL-2 ) , whereas blockade had similar but more modest effects . Negative_regulation TNF PDCD2 18486760 1910903 Overexpression of the gene *results* in inhibited [TNF-alpha] production in activated Daudi cells . Negative_regulation TNF PDCD2 18486760 1910905 Overexpression of gene effectively *attenuated* [tumor necrosis factor (TNF)-alpha] release but elevated interleukin (IL)-6 and PDCD2 expression induced by lipopolysaccharide (LPS) . Negative_regulation TNF PDE4B 18687753 1973595 These findings strongly support the pathogenic *role* of in the ethanol mediated priming of monocytes/macrophages and increased LPS-inducible [TNF] production and the subsequent development of alcoholic liver disease (ALD) . Negative_regulation TNF PDIA2 14704120 1196134 inhibited NF-kappaB activativity in I/R myocardium and *led* to down-regulation of [TNF-alpha] expression , which might be one of molecular mechanisms of Pd-Ia in cardioprotection . Negative_regulation TNF PDIA3 14704120 1196138 inhibited NF-kappaB activativity in I/R myocardium and *led* to down-regulation of [TNF-alpha] expression , which might be one of molecular mechanisms of Pd-Ia in cardioprotection . Negative_regulation TNF PDIA3 22207023 2549736 This is the first study , which reports the *role* of and hnRNP-H in [TNF-a] production in DENV infected cells . Negative_regulation TNF PDIA4 14704120 1196136 inhibited NF-kappaB activativity in I/R myocardium and *led* to down-regulation of [TNF-alpha] expression , which might be one of molecular mechanisms of Pd-Ia in cardioprotection . Negative_regulation TNF PDIA5 14704120 1196135 inhibited NF-kappaB activativity in I/R myocardium and *led* to down-regulation of [TNF-alpha] expression , which might be one of molecular mechanisms of Pd-Ia in cardioprotection . Negative_regulation TNF PDIA6 14704120 1196137 inhibited NF-kappaB activativity in I/R myocardium and *led* to down-regulation of [TNF-alpha] expression , which might be one of molecular mechanisms of Pd-Ia in cardioprotection . Negative_regulation TNF PDLIM2 19052146 2035412 Suppression of expression in THP-1 and RAW 264.7 cells resulted in decreased adhesion , increased NF-kappaB transcription reporter activity , and *increased* LPS induced [TNF-alpha] production . Negative_regulation TNF PDLIM7 18331642 1898141 Treatment of experimental colitis in mice with , an *inhibitor* of [TNF] transcription . Negative_regulation TNF PDLIM7 19439012 2078281 , a small molecular transcriptional *inhibitor* of both [TNF-alpha] and MCP-1 expression , did not reduce MTB induced HIV-1 expression . Negative_regulation TNF PDLIM7 22469483 2700720 , a small molecular *inhibitor* of [TNF-a] , prolongs islet allograft survival by induction of suppressor of cytokine signaling-1 : synergistic effect with cyclosporin-A . Negative_regulation TNF PDLIM7 22469483 2700721 Using a murine model of ITx , we determined the role of , a novel [TNF-a] *inhibitor* , both individually and in combination with the immunosuppressant cyclosporine A ( CSA ) in islet engraftment and survival . Negative_regulation TNF PFN1 1314865 185360 did not *inhibit* [TNF alpha] induction of only those biosynthetic activities also susceptible to PFN in the constitutive state , with PFN failing to reduce constitutive collagenolytic activity but reducing TNF alpha induced enhanced collagenolytic activity by 26 % and collagenase m-RNA by 51 % . Negative_regulation TNF PFN1 1314865 185364 The selective nature of *inhibition* of certain [TNF alpha] activities , the failure of PFN ( 1 mg/ml ) to alter constitutive and TNF alpha induced levels of type 1 and 2 TNF alpha receptor m-RNA , and the finding that PFN treated fibroblasts express a similar number of receptors , of similar molecular weight and high affinity for TNF alpha as control , untreated cells , suggest that inhibitory activities of PFN are mediated at a locus other than receptors for TNF alpha . Negative_regulation TNF PFN2 1314865 185361 did not *inhibit* [TNF alpha] induction of only those biosynthetic activities also susceptible to PFN in the constitutive state , with PFN failing to reduce constitutive collagenolytic activity but reducing TNF alpha induced enhanced collagenolytic activity by 26 % and collagenase m-RNA by 51 % . Negative_regulation TNF PFN2 1314865 185365 The selective nature of *inhibition* of certain [TNF alpha] activities , the failure of PFN ( 1 mg/ml ) to alter constitutive and TNF alpha induced levels of type 1 and 2 TNF alpha receptor m-RNA , and the finding that PFN treated fibroblasts express a similar number of receptors , of similar molecular weight and high affinity for TNF alpha as control , untreated cells , suggest that inhibitory activities of PFN are mediated at a locus other than receptors for TNF alpha . Negative_regulation TNF PFN3 1314865 185358 did not *inhibit* [TNF alpha] induction of only those biosynthetic activities also susceptible to PFN in the constitutive state , with PFN failing to reduce constitutive collagenolytic activity but reducing TNF alpha induced enhanced collagenolytic activity by 26 % and collagenase m-RNA by 51 % . Negative_regulation TNF PFN3 1314865 185362 The selective nature of *inhibition* of certain [TNF alpha] activities , the failure of PFN ( 1 mg/ml ) to alter constitutive and TNF alpha induced levels of type 1 and 2 TNF alpha receptor m-RNA , and the finding that PFN treated fibroblasts express a similar number of receptors , of similar molecular weight and high affinity for TNF alpha as control , untreated cells , suggest that inhibitory activities of PFN are mediated at a locus other than receptors for TNF alpha . Negative_regulation TNF PFN4 1314865 185359 did not *inhibit* [TNF alpha] induction of only those biosynthetic activities also susceptible to PFN in the constitutive state , with PFN failing to reduce constitutive collagenolytic activity but reducing TNF alpha induced enhanced collagenolytic activity by 26 % and collagenase m-RNA by 51 % . Negative_regulation TNF PFN4 1314865 185363 The selective nature of *inhibition* of certain [TNF alpha] activities , the failure of PFN ( 1 mg/ml ) to alter constitutive and TNF alpha induced levels of type 1 and 2 TNF alpha receptor m-RNA , and the finding that PFN treated fibroblasts express a similar number of receptors , of similar molecular weight and high affinity for TNF alpha as control , untreated cells , suggest that inhibitory activities of PFN are mediated at a locus other than receptors for TNF alpha . Negative_regulation TNF PGD 24446972 2918156 Homoisoflavanone down-regulated , LTB4 , and LTC4 production and *inhibited* the production of pro-inflammatory cytokines , such as interleukin-6 and [tumor necrosis factor-a] in PMA/A23187- or IgE/antigen stimulated mast cells . Negative_regulation TNF PGD 7536779 300302 In contrast , constitutive production of [TNF-alpha] was *inhibited* by PGE1 and PGE2 , but not by . Negative_regulation TNF PGD 9298541 453322 7. Since and 17-phenyl-omega-trinor PGE2 ( EP1-agonist ) did not *suppress* [TNF alpha] generation , the EP1/EP2/DP-receptor antagonist , AH 6809 , was employed to assess if EP2-receptors mediated the inhibitory effect of PGE2 . Negative_regulation TNF PGF 12024109 944238 Administration of capsaicin and CGRP significantly enhanced I/R induced increases in hepatic levels of <6-keto-PGF> ( 1alpha ) , increased hepatic-tissue blood flow after reperfusion , and *inhibited* the I/R induced increase in tissue levels of both [tumor necrosis factor-alpha (TNF-alpha)] and myeloperoxidase . Negative_regulation TNF PGF 19471094 2085352 Ang II and LPS stimulated [TNF-alpha] secretion and *inhibited* <6-keto-PGF> ( 1alpha ) production , upregulated MMP-9 and downregulated PPARgamma and PPARalphain rat VSMCs . Negative_regulation TNF PGF 21075851 2376663 Interestingly , we found that activation of E-prostanoid (EP)2 and EP4 receptors , but not EP1 , EP3 , PGI(2) receptor ( IP ) , thromboxane A(2) receptor ( TP ) , PGD(2) receptor ( DP ) , and ( 2 ) receptor ( FP ) , efficiently *blocked* LPS induced [tumor necrosis factor a (TNFa)] synthesis and COX-2 and mPGES-1 induction as well as prostaglandin synthesis in spinal cultures . Negative_regulation TNF PGLYRP3 21176858 2419443 Overexpression of in Caco2 cells down *regulated* the expression of the inflammatory cytokines IL-8 , IL-12 and [TNF-a] , while its silencing increased the expression of these cytokines . Negative_regulation TNF PGP 21701768 2471089 *inhibited* the production of NO and ROS and expression of iNOS , COX-2 , [TNF-a] and IL-1ß , which are involved in the pathogenesis of many inflammation associated human diseases , including septic shock , hemorrhagic shock and rheumatoid arthritis . Negative_regulation TNF PHF1 18341655 1905151 At the RNA level , *suppressed* the transcription of BDNF , TARC , IFN-gamma and [TNF-alpha] . Negative_regulation TNF PHF10 18341655 1905140 At the RNA level , *suppressed* the transcription of BDNF , TARC , IFN-gamma and [TNF-alpha] . Negative_regulation TNF PHF11 18341655 1905138 At the RNA level , *suppressed* the transcription of BDNF , TARC , IFN-gamma and [TNF-alpha] . Negative_regulation TNF PHF12 18341655 1905143 At the RNA level , *suppressed* the transcription of BDNF , TARC , IFN-gamma and [TNF-alpha] . Negative_regulation TNF PHF13 18341655 1905146 At the RNA level , *suppressed* the transcription of BDNF , TARC , IFN-gamma and [TNF-alpha] . Negative_regulation TNF PHF14 18341655 1905144 At the RNA level , *suppressed* the transcription of BDNF , TARC , IFN-gamma and [TNF-alpha] . Negative_regulation TNF PHF15 18341655 1905147 At the RNA level , *suppressed* the transcription of BDNF , TARC , IFN-gamma and [TNF-alpha] . Negative_regulation TNF PHF16 18341655 1905145 At the RNA level , *suppressed* the transcription of BDNF , TARC , IFN-gamma and [TNF-alpha] . Negative_regulation TNF PHF17 18341655 1905150 At the RNA level , *suppressed* the transcription of BDNF , TARC , IFN-gamma and [TNF-alpha] . Negative_regulation TNF PHF19 18341655 1905148 At the RNA level , *suppressed* the transcription of BDNF , TARC , IFN-gamma and [TNF-alpha] . Negative_regulation TNF PHF2 18341655 1905152 At the RNA level , *suppressed* the transcription of BDNF , TARC , IFN-gamma and [TNF-alpha] . Negative_regulation TNF PHF20 18341655 1905137 At the RNA level , *suppressed* the transcription of BDNF , TARC , IFN-gamma and [TNF-alpha] . Negative_regulation TNF PHF23 18341655 1905149 At the RNA level , *suppressed* the transcription of BDNF , TARC , IFN-gamma and [TNF-alpha] . Negative_regulation TNF PHF3 18341655 1905153 At the RNA level , *suppressed* the transcription of BDNF , TARC , IFN-gamma and [TNF-alpha] . Negative_regulation TNF PHF6 18341655 1905139 At the RNA level , *suppressed* the transcription of BDNF , TARC , IFN-gamma and [TNF-alpha] . Negative_regulation TNF PHF7 18341655 1905141 At the RNA level , *suppressed* the transcription of BDNF , TARC , IFN-gamma and [TNF-alpha] . Negative_regulation TNF PHF8 18341655 1905142 At the RNA level , *suppressed* the transcription of BDNF , TARC , IFN-gamma and [TNF-alpha] . Negative_regulation TNF PI3 11247802 793351 Akt/PKB activation by [TNF-alpha] was *inhibited* by a PI3-kinase-specific inhibitor LY-294002 and adenovirus mediated expression of a dominant negative mutant of , indicating that TNF-alpha activates Akt/PKB through PI3-kinase activation . Negative_regulation TNF PI3 11429162 831579 Suppression of signaling markedly *enhanced* the apoptotic activity of both [TNF] and TRAIL in LNCaP cells but not in PC-3 cells . Negative_regulation TNF PI3 12055072 951590 A *role* for PKC-delta and in [TNF-alpha] mediated antiapoptotic signaling in the human neutrophil . Negative_regulation TNF PI3 12055072 951602 In this study , a *role* for PKC-delta and in [TNF-alpha] mediated antiapoptotic signaling was examined . Negative_regulation TNF PIAS2 9124369 419520 APC , but not DEGR-Xa or , significantly *inhibited* the LPS induced increase in the plasma level of [TNF] . Negative_regulation TNF PIK3C3 12360479 994922 The effect of PTEN or *inhibition* and [tumor necrosis factor] alpha on Cdx-2 messenger RNA and protein expression , Cdx-2 DNA binding activity , and the promoter activity of the Cdx-2 gene was analyzed in human colon cancer cell lines . Negative_regulation TNF PIK3CA 14688354 1190704 Inhibition of *resulted* in increased serum levels of IL1-beta , IL-2 , IL-6 , IL-10 , IL-12 , and [TNF-alpha] in septic mice . Negative_regulation TNF PIK3CA 17522703 1804540 To test this hypothesis , cultured normal human keratinocytes were treated with [TNF-alpha] in the *presence* of a inhibitor to suppress Akt activation . Negative_regulation TNF PIK3CA 19915052 2166516 The inhibitory effect of TLR2 on the release of [TNF-alpha] but not of IL-12p70 was *mediated* by . Negative_regulation TNF PIK3CA 21098227 2355109 In this study , we demonstrate that the induction of [TNF] and IL-6 expression by LVS in mouse bone marrow derived macrophages was markedly *enhanced* when activity was inhibited by either of the well-known chemical inhibitors , wortmannin or LY294002 . Negative_regulation TNF PIK3R1 14688354 1190705 Inhibition of *resulted* in increased serum levels of IL1-beta , IL-2 , IL-6 , IL-10 , IL-12 , and [TNF-alpha] in septic mice . Negative_regulation TNF PIK3R1 17522703 1804541 To test this hypothesis , cultured normal human keratinocytes were treated with [TNF-alpha] in the *presence* of a inhibitor to suppress Akt activation . Negative_regulation TNF PIK3R1 19915052 2166517 The inhibitory effect of TLR2 on the release of [TNF-alpha] but not of IL-12p70 was *mediated* by . Negative_regulation TNF PIK3R1 21098227 2355110 In this study , we demonstrate that the induction of [TNF] and IL-6 expression by LVS in mouse bone marrow derived macrophages was markedly *enhanced* when activity was inhibited by either of the well-known chemical inhibitors , wortmannin or LY294002 . Negative_regulation TNF PIK3R1 23042638 2833286 significantly *reduced* the upregulation of [tumor necrosis factor-a] , interleukin (IL)-1ß and IL-6 mRNA in the brain tissue at 4 h after LPS injection . Negative_regulation TNF PIK3R4 12360479 994923 The effect of PTEN or *inhibition* and [tumor necrosis factor] alpha on Cdx-2 messenger RNA and protein expression , Cdx-2 DNA binding activity , and the promoter activity of the Cdx-2 gene was analyzed in human colon cancer cell lines . Negative_regulation TNF PLA2G15 21300120 2403526 84 also significantly *attenuated* nitric oxide release and [TNF-a] production in BV-2 cells treated with Aß peptides ( Aß ( 1-40 ) or Aß ( 1-42 ) ) , but had no significant effect on the up-regulated protein expression of cyclooxygenase 2 . Negative_regulation TNF PLAU 10892857 711301 Both IL-1beta and [TNF-alpha] *induced* a significant decrease in expression in PBF , whereas bFGF induced a slight increase in both HJF and PBF . Negative_regulation TNF PLCB1 19850892 2170173 Selective down-regulation of PLCbeta2 , but not , using small interfering RNA resulted in increased VEGF expression in response to A ( 2A ) R agonists , but did not *suppress* [TNFalpha] expression . Negative_regulation TNF PLCG1 18079103 1874533 The purpose of this study was to investigate the *role* of phosphatidylinositol ( PI ) ( PLCgamma1 ) in cardiac [TNF-alpha] expression , and myocardial dysfunction during endotoxemia . Negative_regulation TNF PLD1 24548427 2915094 The purpose of this study was to identify the *role* of in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression and production . Negative_regulation TNF PLD1 24548427 2915101 To investigate the *role* of in LPS induced [TNF-a] expression and production , we transfected PLD1 and PLD2 siRNAs to Raw 264.7 cells , respectively . Negative_regulation TNF PLD2 24548427 2915102 To investigate the *role* of in LPS induced [TNF-a] expression and production , we transfected PLD1 and PLD2 siRNAs to Raw 264.7 cells , respectively . Negative_regulation TNF PLD3 24548427 2915097 To investigate the *role* of in LPS induced [TNF-a] expression and production , we transfected PLD1 and PLD2 siRNAs to Raw 264.7 cells , respectively . Negative_regulation TNF PLD4 24548427 2915098 To investigate the *role* of in LPS induced [TNF-a] expression and production , we transfected PLD1 and PLD2 siRNAs to Raw 264.7 cells , respectively . Negative_regulation TNF PLD5 24548427 2915099 To investigate the *role* of in LPS induced [TNF-a] expression and production , we transfected PLD1 and PLD2 siRNAs to Raw 264.7 cells , respectively . Negative_regulation TNF PLD6 24548427 2915100 To investigate the *role* of in LPS induced [TNF-a] expression and production , we transfected PLD1 and PLD2 siRNAs to Raw 264.7 cells , respectively . Negative_regulation TNF PLG 17395890 1766210 Hirudin , a thrombin inhibitor , and aprotinin , an inhibitor of plasmin , reduced smoke mediated [TNF-alpha] and MMP-12 release , and A1AT *inhibited* both and thrombin activity in a cell-free functional assay . Negative_regulation TNF PLN 10030792 591780 also *attenuated* NO and [TNF alpha] production from the Kupffer cells . Negative_regulation TNF PMEL 21806998 2467744 Increase in lucigenin CL and serum [TNF-a] levels in the colitis group were also *prevented* by ( p < 0.001 and p < 0.01 , respectively ) . Negative_regulation TNF POLDIP2 11920316 926075 The *role* of and extracellular signal regulated kinase ( ERK ) mitogen activated protein (MAP) kinase pathways in the up-regulation of inducible nitric oxide synthase (iNOS) and [tumor necrosis factor (TNF)] production in macrophages stimulated with Streptococcus pneumoniae was examined . Negative_regulation TNF POLDIP2 17668318 1805302 Pharmacological inhibitor of tyrosine kinase , PI3 kinase , protein kinase C , p42/44 , , JNK and intracellular calcium immobilizing agent down *regulated* the WGA induced expression of cytokines [TNF-alpha] , IL-1beta , IL-12 and IFN-gamma . Negative_regulation TNF POLDIP2 19192109 2049513 Microparticle generation from cultures of human aortic endothelial cells ( hAECs ) treated with [tumor necrosis factor-alpha (TNF-alpha)] and *inhibition* was quantified via multiple modalities . Negative_regulation TNF POLDIP2 23518420 2777181 HKC could dose-dependently ameliorate renal inflammation and glomerular injury in ADRN rats , by way of reducing the infiltration and the activation of macrophages in glomeruli , and [TNF-a] protein expression in the kidney , as well as *inhibiting* signaling pathway activity via the down-regulation of p-p38MAPK and TGF-ß1 protein expressions in vivo . Negative_regulation TNF PON1 21986851 2567861 *attenuated* [TNF-a] , NO , and NADP ( + ) production in macrophages on stimulation with LPS plus IFN-? . Negative_regulation TNF PPARA 11009565 735946 These results suggest that both and PPARgamma activators *inhibit* cardiac expression of [TNF-alpha] in part by antagonizing nuclear factor-kappaB activity and that treatment with PPAR activators may lead to improvement in congestive heart failure . Negative_regulation TNF PPARA 11934839 927887 activators also *inhibited* [TNFalpha] and interleukin-2 protein expression . Negative_regulation TNF PPARA 15891579 1407416 activators also *suppressed* lipopolysaccharide stimulated [tumor necrosis factor-alpha] and monocyte chemoattractant protein-1 transcription and release . Negative_regulation TNF PPARA 17320860 1711783 The activators may *suppress* the pathogenetical secretion of [TNFalpha] in the adipocytes through the functional modulation of the infiltrated macrophages . Negative_regulation TNF PPARA 24626526 2925528 PIO may activate to *inhibit* the expression of the inflammatory cytokines [TNF-a] and IL-1ß in dry eye mice . Negative_regulation TNF PPARG 10917568 716783 The effect of activation of peroxisome proliferator activated receptor gamma ( PPARgamma ) on human monocyte function : ligands do not *inhibit* [tumor necrosis factor-alpha] release in human monocytic cell line THP-1 . Negative_regulation TNF PPARG 10917568 716785 We concluded that ligands did not directly *inhibit* [TNF-alpha] release in THP-1 cells . Negative_regulation TNF PPARG 11009565 735947 These results suggest that both PPARalpha and activators *inhibit* cardiac expression of [TNF-alpha] in part by antagonizing nuclear factor-kappaB activity and that treatment with PPAR activators may lead to improvement in congestive heart failure . Negative_regulation TNF PPARG 11159886 781447 Activation of *resulted* in down-regulation of intercellular adhesion molecule 1 expression by intestinal endothelium and tissue [tumor necrosis factor] alpha messenger RNA levels most likely by inhibition of the NF-kappa B pathway . Negative_regulation TNF PPARG 11369514 817425 Since the fact that peroxisome proliferator activated receptor gamma ( ) ligands *inhibit* the induction of [TNF-alpha] by phorbol ester , but not by lipopolysaccharide (LPS) , suggests two pathways to induce TNF-alpha , we investigated the mechanisms of glycated human albumin ( GHA ) - or phorbol ester induced TNF-alpha in THP-1 cells . Negative_regulation TNF PPARG 11456275 838125 In fully differentiated adipocytes , [TNF-alpha] rapidly *induced* C/EBPbeta and C/EBPdelta , whereas it downregulated the expression of C/EBPalpha and . Negative_regulation TNF PPARG 15669179 1350505 PPAR alpha and activators may *inhibit* cardiac [TNFalpha] expression but not accompanied by change of PPAR alpha or PPAR gamma mRNA expression . Negative_regulation TNF PPIB 22798670 2639915 *attenuates* the expression of [TNF-a] in lipopolysaccharide stimulated macrophages through the induction of B cell lymphoma-3 . Negative_regulation TNF PPM1D 23959423 2866281 In vitro studies indicated that the upregulation of Wip1 may be involved in the subsequent astrocytic activation following LPS exposure , and knockdown of Wip1 in primary astrocytes by siRNA showed that *inhibited* the synthesis of [TNF-a] . Negative_regulation TNF PPP1R3A 24035860 2862552 The results showed that or Cort could *reduce* the production of NO and [TNF-a] , and Rg1 dose-dependently up-regulated GR expression , while Cort dose-dependently down-regulated GR expression . Negative_regulation TNF PPP2CA 15618191 1357639 Our studies are the first to demonstrate an important role for the transcription factor CREB in [TNF-alpha] production by mycobacterium infected macrophages , as well as a *role* for M. avium 's induction of phosphatase activity as a mechanism to limit macrophage activation . Negative_regulation TNF PPP2CA 17314097 1719494 Interestingly , peptides spanning CCR2 and/or LZ disrupt IKKgamma-Tax and interactions and potently *inhibit* NF-kappaB activation by Tax and [tumor necrosis factor-alpha] . Negative_regulation TNF PPP2CA 20363734 2266635 We found that either inhibitor okadaic acid or depletion of catalytic subunit alpha of PP2A ( PP2A/Calpha ) by small interfering RNA enhanced Bcl-x ( L ) phosphorylation when activated with hydrogen peroxide and [tumor necrosis factor] alpha *induced* oxidative stress . Negative_regulation TNF PPP2CA 22718360 2715389 Moreover , ATRA and LGD1069 reversed the decreased activity and *inhibited* the activation of IKK/I?Ba and gene expression of MCP-1 , IL-6 , and [TNF-a] in the hearts of Zucker diabetic fatty rats . Negative_regulation TNF PPP2R1A 15618191 1357640 Our studies are the first to demonstrate an important role for the transcription factor CREB in [TNF-alpha] production by mycobacterium infected macrophages , as well as a *role* for M. avium 's induction of phosphatase activity as a mechanism to limit macrophage activation . Negative_regulation TNF PPP2R1A 17314097 1719495 Interestingly , peptides spanning CCR2 and/or LZ disrupt IKKgamma-Tax and interactions and potently *inhibit* NF-kappaB activation by Tax and [tumor necrosis factor-alpha] . Negative_regulation TNF PPP2R1A 20363734 2266636 We found that either inhibitor okadaic acid or depletion of catalytic subunit alpha of PP2A ( PP2A/Calpha ) by small interfering RNA enhanced Bcl-x ( L ) phosphorylation when activated with hydrogen peroxide and [tumor necrosis factor] alpha *induced* oxidative stress . Negative_regulation TNF PPP2R1A 22718360 2715390 Moreover , ATRA and LGD1069 reversed the decreased activity and *inhibited* the activation of IKK/I?Ba and gene expression of MCP-1 , IL-6 , and [TNF-a] in the hearts of Zucker diabetic fatty rats . Negative_regulation TNF PPP2R2B 15618191 1357641 Our studies are the first to demonstrate an important role for the transcription factor CREB in [TNF-alpha] production by mycobacterium infected macrophages , as well as a *role* for M. avium 's induction of phosphatase activity as a mechanism to limit macrophage activation . Negative_regulation TNF PPP2R2B 17314097 1719496 Interestingly , peptides spanning CCR2 and/or LZ disrupt IKKgamma-Tax and interactions and potently *inhibit* NF-kappaB activation by Tax and [tumor necrosis factor-alpha] . Negative_regulation TNF PPP2R2B 20363734 2266637 We found that either PP2A inhibitor okadaic acid or depletion of catalytic subunit alpha of ( PP2A/Calpha ) by small interfering RNA enhanced Bcl-x ( L ) phosphorylation when activated with hydrogen peroxide and [tumor necrosis factor] alpha *induced* oxidative stress . Negative_regulation TNF PPP2R2B 22718360 2715391 Moreover , ATRA and LGD1069 reversed the decreased activity and *inhibited* the activation of IKK/I?Ba and gene expression of MCP-1 , IL-6 , and [TNF-a] in the hearts of Zucker diabetic fatty rats . Negative_regulation TNF PPP3CA 16380462 1539840 Collectively , these data verify the *role* of and NFAT in CaR mediated [TNF] production by mTAL cells . Negative_regulation TNF PPP3CB 16380462 1539841 Collectively , these data verify the *role* of and NFAT in CaR mediated [TNF] production by mTAL cells . Negative_regulation TNF PPP3CC 16380462 1539842 Collectively , these data verify the *role* of and NFAT in CaR mediated [TNF] production by mTAL cells . Negative_regulation TNF PRDX2 17499201 1739932 On the other hand , the release of [TNF-alpha] and IL-10 induced by LP in PBMCs was *inhibited* by while NP inhibited the release of IFN-gamma and IL-10 . Negative_regulation TNF PRDX2 17675290 1794061 In human umbilical vein endothelial cells , *attenuates* by approximately 70 % [TNF-alpha] stimulation of TF mRNA transcription without affecting that of ICAM-1 . Negative_regulation TNF PRDX2 19083427 2003450 and *down-regulated* [TNF-alpha] secretion but all up-regulated PGE ( 2 ) secretion . Negative_regulation TNF PRDX2 19083427 2003453 The results showed that butyrate , propionate , and *inhibited* [TNF-alpha] production via PGE ( 2 ) secretion and down-regulated NF-kappaB activation by lipopolysaccharide . Negative_regulation TNF PRDX2 20130413 2293648 [TNFalpha] stimulation activated NF-kappaB through induction of IkappaB phosphorylation , but the activation can be *suppressed* by . Negative_regulation TNF PRDX2 20573419 2302933 *inhibited* the production of IFN-I , TRAIL and of the pro-inflammatory cytokines [TNFalpha] and IL-6 by CpG activated PDC . Negative_regulation TNF PRDX2 22768247 2623564 ELISA demonstrated that could *inhibit* MIF expression and the release of [TNF-a] and IL-6 induced by I/R injury . Negative_regulation TNF PRG2 12096231 960881 Both PBMC and IL-1beta plus [TNF-alpha] *induced* strong inhibition of cartilage synthesis and significant enhancement of the release of proteoglycans , diminishing proteoglycan content . Negative_regulation TNF PRG2 1863822 163996 In both young and old human articular cartilage explants , [TNF alpha] *induced* a concentration dependent , reversible suppression of the synthesis . Negative_regulation TNF PRG2 3498042 77898 [Tumor necrosis factor] also has been shown to cause similar cartilage degradation and both cytokines *inhibit* resynthesis of . Negative_regulation TNF PRG3 12096231 960882 Both PBMC and IL-1beta plus [TNF-alpha] *induced* strong inhibition of cartilage synthesis and significant enhancement of the release of proteoglycans , diminishing proteoglycan content . Negative_regulation TNF PRG3 1863822 163997 In both young and old human articular cartilage explants , [TNF alpha] *induced* a concentration dependent , reversible suppression of the synthesis . Negative_regulation TNF PRG3 3498042 77899 [Tumor necrosis factor] also has been shown to cause similar cartilage degradation and both cytokines *inhibit* resynthesis of . Negative_regulation TNF PRG4 12096231 960883 Both PBMC and IL-1beta plus [TNF-alpha] *induced* strong inhibition of cartilage synthesis and significant enhancement of the release of proteoglycans , diminishing proteoglycan content . Negative_regulation TNF PRG4 1863822 163998 In both young and old human articular cartilage explants , [TNF alpha] *induced* a concentration dependent , reversible suppression of the synthesis . Negative_regulation TNF PRG4 3498042 77900 [Tumor necrosis factor] also has been shown to cause similar cartilage degradation and both cytokines *inhibit* resynthesis of . Negative_regulation TNF PRKAA1 16636195 1562945 A pharmacological activator of , 5-amino-4-imidazole carboxamide riboside ( AICAR ) , dose-dependently *inhibited* [TNF-alpha-] and interleukin-1beta induced NF-kappaB reporter gene expression . Negative_regulation TNF PRKAA1 17717055 1807515 In parallel , the pharmacological activation of hypothalamic in TB animals markedly *reduced* the hypothalamic production of inducible nitric oxide synthase , IL-1beta , and [TNF-alpha] and modulated the expression of proopiomelanocortin , a hypothalamic neuropeptide that is involved in the control of energy homeostasis . Negative_regulation TNF PRKAA1 19853624 2196730 Furthermore , we found that the effects of AICAR on IL-6 and [TNF-alpha] ( 12 , 24h ) release and on the expression of iNOS and NF-kappaB p65 are not *dependent* because the pre-treatment of LPS activated microglia with compound C ( a pharmacological inhibitor of AMPK ) did not reverse the effect of AICAR . Negative_regulation TNF PRKAA2 16636195 1562946 A pharmacological activator of , 5-amino-4-imidazole carboxamide riboside ( AICAR ) , dose-dependently *inhibited* [TNF-alpha-] and interleukin-1beta induced NF-kappaB reporter gene expression . Negative_regulation TNF PRKAA2 17717055 1807516 In parallel , the pharmacological activation of hypothalamic in TB animals markedly *reduced* the hypothalamic production of inducible nitric oxide synthase , IL-1beta , and [TNF-alpha] and modulated the expression of proopiomelanocortin , a hypothalamic neuropeptide that is involved in the control of energy homeostasis . Negative_regulation TNF PRKAA2 19853624 2196731 Furthermore , we found that the effects of AICAR on IL-6 and [TNF-alpha] ( 12 , 24h ) release and on the expression of iNOS and NF-kappaB p65 are not *dependent* because the pre-treatment of LPS activated microglia with compound C ( a pharmacological inhibitor of AMPK ) did not reverse the effect of AICAR . Negative_regulation TNF PRKAB1 16636195 1562947 A pharmacological activator of , 5-amino-4-imidazole carboxamide riboside ( AICAR ) , dose-dependently *inhibited* [TNF-alpha-] and interleukin-1beta induced NF-kappaB reporter gene expression . Negative_regulation TNF PRKAB1 17717055 1807517 In parallel , the pharmacological activation of hypothalamic in TB animals markedly *reduced* the hypothalamic production of inducible nitric oxide synthase , IL-1beta , and [TNF-alpha] and modulated the expression of proopiomelanocortin , a hypothalamic neuropeptide that is involved in the control of energy homeostasis . Negative_regulation TNF PRKAB1 19853624 2196732 Furthermore , we found that the effects of AICAR on IL-6 and [TNF-alpha] ( 12 , 24h ) release and on the expression of iNOS and NF-kappaB p65 are not *dependent* because the pre-treatment of LPS activated microglia with compound C ( a pharmacological inhibitor of AMPK ) did not reverse the effect of AICAR . Negative_regulation TNF PRKAB2 16636195 1562948 A pharmacological activator of , 5-amino-4-imidazole carboxamide riboside ( AICAR ) , dose-dependently *inhibited* [TNF-alpha-] and interleukin-1beta induced NF-kappaB reporter gene expression . Negative_regulation TNF PRKAB2 17717055 1807518 In parallel , the pharmacological activation of hypothalamic in TB animals markedly *reduced* the hypothalamic production of inducible nitric oxide synthase , IL-1beta , and [TNF-alpha] and modulated the expression of proopiomelanocortin , a hypothalamic neuropeptide that is involved in the control of energy homeostasis . Negative_regulation TNF PRKAB2 19853624 2196733 Furthermore , we found that the effects of AICAR on IL-6 and [TNF-alpha] ( 12 , 24h ) release and on the expression of iNOS and NF-kappaB p65 are not *dependent* because the pre-treatment of LPS activated microglia with compound C ( a pharmacological inhibitor of AMPK ) did not reverse the effect of AICAR . Negative_regulation TNF PRKACB 15634874 1362602 By contrast , activation of , but not Epac-1 , *suppressed* AM production of leukotriene B ( 4 ) and [TNF-alpha] , whereas stimulation of either PKA or Epac-1 inhibited AM bactericidal activity and H ( 2 ) O ( 2 ) production . Negative_regulation TNF PRKACB 19531803 2098814 Suppression of LPS induced [TNF-alpha] production in macrophages by cAMP is *mediated* by . Negative_regulation TNF PRKACB 20303596 2230481 Furthermore , inhibitors of p38 and MSK1 , but not , completely *blocked* the production of IL-10 and [TNFalpha] in LPS stimulated macrophages . Negative_regulation TNF PRKACB 21247892 2409368 AKAP10 also mediated PGE ( 2 ) potentiation of the expression of cytokines IL-10 and IL-6 , whereas PGE ( 2 ) suppression of [TNF-a] was *mediated* by AKAP8 anchored . Negative_regulation TNF PRKACB 7476903 326652 When PGE2 was used to activate adenylyl cyclase , however , rolipram potentiated cAMP accumulation , activation , and *inhibition* of [TNF-alpha] generation . Negative_regulation TNF PRKACG 15634874 1362603 By contrast , activation of , but not Epac-1 , *suppressed* AM production of leukotriene B ( 4 ) and [TNF-alpha] , whereas stimulation of either PKA or Epac-1 inhibited AM bactericidal activity and H ( 2 ) O ( 2 ) production . Negative_regulation TNF PRKACG 19531803 2098815 Suppression of LPS induced [TNF-alpha] production in macrophages by cAMP is *mediated* by . Negative_regulation TNF PRKACG 20303596 2230482 Furthermore , inhibitors of p38 and MSK1 , but not , completely *blocked* the production of IL-10 and [TNFalpha] in LPS stimulated macrophages . Negative_regulation TNF PRKACG 21247892 2409369 AKAP10 also mediated PGE ( 2 ) potentiation of the expression of cytokines IL-10 and IL-6 , whereas PGE ( 2 ) suppression of [TNF-a] was *mediated* by AKAP8 anchored . Negative_regulation TNF PRKACG 7476903 326653 When PGE2 was used to activate adenylyl cyclase , however , rolipram potentiated cAMP accumulation , activation , and *inhibition* of [TNF-alpha] generation . Negative_regulation TNF PRKAG1 16636195 1562949 A pharmacological activator of , 5-amino-4-imidazole carboxamide riboside ( AICAR ) , dose-dependently *inhibited* [TNF-alpha-] and interleukin-1beta induced NF-kappaB reporter gene expression . Negative_regulation TNF PRKAG1 17717055 1807519 In parallel , the pharmacological activation of hypothalamic in TB animals markedly *reduced* the hypothalamic production of inducible nitric oxide synthase , IL-1beta , and [TNF-alpha] and modulated the expression of proopiomelanocortin , a hypothalamic neuropeptide that is involved in the control of energy homeostasis . Negative_regulation TNF PRKAG1 19853624 2196734 Furthermore , we found that the effects of AICAR on IL-6 and [TNF-alpha] ( 12 , 24h ) release and on the expression of iNOS and NF-kappaB p65 are not *dependent* because the pre-treatment of LPS activated microglia with compound C ( a pharmacological inhibitor of AMPK ) did not reverse the effect of AICAR . Negative_regulation TNF PRKAG2 16636195 1562950 A pharmacological activator of , 5-amino-4-imidazole carboxamide riboside ( AICAR ) , dose-dependently *inhibited* [TNF-alpha-] and interleukin-1beta induced NF-kappaB reporter gene expression . Negative_regulation TNF PRKAG2 17717055 1807520 In parallel , the pharmacological activation of hypothalamic in TB animals markedly *reduced* the hypothalamic production of inducible nitric oxide synthase , IL-1beta , and [TNF-alpha] and modulated the expression of proopiomelanocortin , a hypothalamic neuropeptide that is involved in the control of energy homeostasis . Negative_regulation TNF PRKAG2 19853624 2196735 Furthermore , we found that the effects of AICAR on IL-6 and [TNF-alpha] ( 12 , 24h ) release and on the expression of iNOS and NF-kappaB p65 are not *dependent* because the pre-treatment of LPS activated microglia with compound C ( a pharmacological inhibitor of AMPK ) did not reverse the effect of AICAR . Negative_regulation TNF PRKAR1A 15634874 1362604 By contrast , activation of , but not Epac-1 , *suppressed* AM production of leukotriene B ( 4 ) and [TNF-alpha] , whereas stimulation of either PKA or Epac-1 inhibited AM bactericidal activity and H ( 2 ) O ( 2 ) production . Negative_regulation TNF PRKAR1A 19531803 2098816 Suppression of LPS induced [TNF-alpha] production in macrophages by cAMP is *mediated* by . Negative_regulation TNF PRKAR1A 20303596 2230483 Furthermore , inhibitors of p38 and MSK1 , but not , completely *blocked* the production of IL-10 and [TNFalpha] in LPS stimulated macrophages . Negative_regulation TNF PRKAR1A 21247892 2409370 AKAP10 also mediated PGE ( 2 ) potentiation of the expression of cytokines IL-10 and IL-6 , whereas PGE ( 2 ) suppression of [TNF-a] was *mediated* by AKAP8 anchored . Negative_regulation TNF PRKAR1A 7476903 326654 When PGE2 was used to activate adenylyl cyclase , however , rolipram potentiated cAMP accumulation , activation , and *inhibition* of [TNF-alpha] generation . Negative_regulation TNF PRKAR1B 15634874 1362605 By contrast , activation of , but not Epac-1 , *suppressed* AM production of leukotriene B ( 4 ) and [TNF-alpha] , whereas stimulation of either PKA or Epac-1 inhibited AM bactericidal activity and H ( 2 ) O ( 2 ) production . Negative_regulation TNF PRKAR1B 19531803 2098817 Suppression of LPS induced [TNF-alpha] production in macrophages by cAMP is *mediated* by . Negative_regulation TNF PRKAR1B 20303596 2230484 Furthermore , inhibitors of p38 and MSK1 , but not , completely *blocked* the production of IL-10 and [TNFalpha] in LPS stimulated macrophages . Negative_regulation TNF PRKAR1B 21247892 2409371 AKAP10 also mediated PGE ( 2 ) potentiation of the expression of cytokines IL-10 and IL-6 , whereas PGE ( 2 ) suppression of [TNF-a] was *mediated* by AKAP8 anchored . Negative_regulation TNF PRKAR1B 7476903 326655 When PGE2 was used to activate adenylyl cyclase , however , rolipram potentiated cAMP accumulation , activation , and *inhibition* of [TNF-alpha] generation . Negative_regulation TNF PRKAR2A 15634874 1362606 By contrast , activation of , but not Epac-1 , *suppressed* AM production of leukotriene B ( 4 ) and [TNF-alpha] , whereas stimulation of either PKA or Epac-1 inhibited AM bactericidal activity and H ( 2 ) O ( 2 ) production . Negative_regulation TNF PRKAR2A 19531803 2098818 Suppression of LPS induced [TNF-alpha] production in macrophages by cAMP is *mediated* by . Negative_regulation TNF PRKAR2A 20303596 2230485 Furthermore , inhibitors of p38 and MSK1 , but not , completely *blocked* the production of IL-10 and [TNFalpha] in LPS stimulated macrophages . Negative_regulation TNF PRKAR2A 21247892 2409372 AKAP10 also mediated PGE ( 2 ) potentiation of the expression of cytokines IL-10 and IL-6 , whereas PGE ( 2 ) suppression of [TNF-a] was *mediated* by AKAP8 anchored . Negative_regulation TNF PRKAR2A 7476903 326656 When PGE2 was used to activate adenylyl cyclase , however , rolipram potentiated cAMP accumulation , activation , and *inhibition* of [TNF-alpha] generation . Negative_regulation TNF PRKAR2B 15634874 1362607 By contrast , activation of , but not Epac-1 , *suppressed* AM production of leukotriene B ( 4 ) and [TNF-alpha] , whereas stimulation of either PKA or Epac-1 inhibited AM bactericidal activity and H ( 2 ) O ( 2 ) production . Negative_regulation TNF PRKAR2B 19531803 2098819 Suppression of LPS induced [TNF-alpha] production in macrophages by cAMP is *mediated* by . Negative_regulation TNF PRKAR2B 20303596 2230486 Furthermore , inhibitors of p38 and MSK1 , but not , completely *blocked* the production of IL-10 and [TNFalpha] in LPS stimulated macrophages . Negative_regulation TNF PRKAR2B 21247892 2409373 AKAP10 also mediated PGE ( 2 ) potentiation of the expression of cytokines IL-10 and IL-6 , whereas PGE ( 2 ) suppression of [TNF-a] was *mediated* by AKAP8 anchored . Negative_regulation TNF PRKAR2B 7476903 326657 When PGE2 was used to activate adenylyl cyclase , however , rolipram potentiated cAMP accumulation , activation , and *inhibition* of [TNF-alpha] generation . Negative_regulation TNF PRKCA 16964312 1627743 Inhibiting also *reduced* the basal and [TNF-alpha-] or TPA induced expression of CXCL8 in cultured psoriatic keratinocytes , suggesting that PKCalpha activity may contribute to psoriatic inflammation . Negative_regulation TNF PRKDC 9636658 513380 The *role* of , a protein kinase involved in the response to DNA damage , in the activation of NF kappa B by IR and [TNF alpha] was examined . Negative_regulation TNF PRL 11752888 890097 The suppressive action of bromoergocryptine , a dopamine D2 receptor agonist , on LPS induced [TNF-alpha] release may be *mediated* in part by suppression of release , which triggers TNF-alpha release . Negative_regulation TNF PRL 9741828 532163 The presence of lipopolysaccharide ( LPS , 0.1 microg/mL ) in the culture medium significantly increased [TNF-alpha] release and *inhibited* release . Negative_regulation TNF PRLR 24997655 2952761 This study aims to investigate the *role* of activation in regulating the expression and release of [TNF-a] from CD14 ( + ) monocytes . Negative_regulation TNF PROC 10810875 692778 *inhibits* [TNF-alpha] production by monocyte dependent of its protease activity . Negative_regulation TNF PROC 11022125 737969 *inhibits* [tumor necrosis factor] and macrophage migration inhibitory factor production in monocytes . Negative_regulation TNF PROC 12195699 981732 *inhibits* lipopolysaccharide induced [tumor necrosis factor-alpha] production by inhibiting activation of both nuclear factor-kappa B and activator protein-1 in human monocytes . Negative_regulation TNF PROC 16887970 1596694 With respect to inflammation , *inhibited* the production of [TNF] , IL-1beta , IL-6 , and IL-8 by LPS stimulated THP-1 cells . Negative_regulation TNF PRPH2 24257684 2892704 Whereas [TNF-a] release was *reduced* by 48.1 ± 15.4 % , 33.0 ± 10.0 % and 46.7 ± 8.7 % by RES , R3S and , respectively . Negative_regulation TNF PRTN3 12067299 954959 Human can *inhibits* LPS mediated [TNF-alpha] production through CD14 degradation : lack of influence of antineutrophil cytoplasmic antibodies . Negative_regulation TNF PRX 22609006 2632295 Keap1 knockdown also *inhibited* endotoxin induced expression of inducible nitric oxide synthase (iNOS) and [TNF-a] by upregulating HO-1 , GCL , and expression in macrophages . Negative_regulation TNF PSD 18986529 2001354 Results showed that although fish oil diet did not exert any effect upon these measurements , *induced* a reduction in adiponectin gene expression of retroperitoneal adipose tissues , with no change in serum adiponectin concentration or in adiponectin and [TNF-alpha] gene expression of epididymal adipose tissue . Negative_regulation TNF PSMC3 9209275 441021 In addition , *inhibited* membrane bound [TNF] induced activation of human brain MVEC , but the concentration required was about 10-fold higher than that for soluble TNF . Negative_regulation TNF PTAFR 15128823 1245269 The presence of the in KB cells *resulted* in augmentation of the production of cytokines IL-8 and [TNF-alpha] induced by the chemotherapeutic agents etoposide and mitomycin C . Negative_regulation TNF PTAFR 19769579 2258184 These studies suggest that concomitant activation and UVB irradiation *results* in a synergistic production of the cytokine [TNF-alpha] which is mediated in part via PKC . Negative_regulation TNF PTBP1 21885868 2496471 Targeting and ATMs with curcusomes in ob/ob mice reduced NF-?B/RelA DNA binding activity , *reduced* [TNF] , and enhanced interleukin-4 production . Negative_regulation TNF PTBP2 21885868 2496468 Targeting and ATMs with curcusomes in ob/ob mice reduced NF-?B/RelA DNA binding activity , *reduced* [TNF] , and enhanced interleukin-4 production . Negative_regulation TNF PTEN 11356844 834468 Expression of in PC-3 cells to a level comparable with that endogenously present in DU145 cells *inhibited* [TNF] activation of NF-kappaB . Negative_regulation TNF PTEN 17373630 1713843 *Role* of tumor suppressor in [tumor necrosis factor] alpha induced inhibition of insulin signaling in murine skeletal muscle C2C12 cells . Negative_regulation TNF PTEN 19593846 2105352 Quantitative real-time PCR assays showed that CE treatment decreased the mRNA expression of IL-1beta , IL-6 and [TNF-alpha] , improved the mRNA expression of IR , IRS1 , IRS2 , PI3K and Akt1 , *inhibited* CD36 , MTTP , and , and enhanced the impaired SREBP-1c expression in TNF-alpha treated enterocytes . Negative_regulation TNF PTGER2 15075356 1265793 Synovial cells from mice with pristane induced arthritis ( DBA/1 ) also expressed , and the EP2/4 agonist *inhibited* [TNF-alpha] production . Negative_regulation TNF PTGER3 21075851 2376664 Interestingly , we found that activation of E-prostanoid (EP)2 and EP4 receptors , but not EP1 , , PGI(2) receptor ( IP ) , thromboxane A(2) receptor ( TP ) , PGD(2) receptor ( DP ) , and PGF ( 2 ) receptor ( FP ) , efficiently *blocked* LPS induced [tumor necrosis factor a (TNFa)] synthesis and COX-2 and mPGES-1 induction as well as prostaglandin synthesis in spinal cultures . Negative_regulation TNF PTGER4 21075851 2376665 Interestingly , we found that activation of E-prostanoid (EP)2 and receptors , but not EP1 , EP3 , PGI(2) receptor ( IP ) , thromboxane A(2) receptor ( TP ) , PGD(2) receptor ( DP ) , and PGF ( 2 ) receptor ( FP ) , efficiently *blocked* LPS induced [tumor necrosis factor a (TNFa)] synthesis and COX-2 and mPGES-1 induction as well as prostaglandin synthesis in spinal cultures . Negative_regulation TNF PTGER4 21910594 2567682 IND and EP4A inhibited the upregulation of [TNF-a] mRNA expression , and only *inhibited* IL-6 and RANKL mRNA expressions in ST2 cells with LPS stimulation . Negative_regulation TNF PTGIR 21075851 2376666 Interestingly , we found that activation of E-prostanoid (EP)2 and EP4 receptors , but not EP1 , EP3 , ( IP ) , thromboxane A(2) receptor ( TP ) , PGD(2) receptor ( DP ) , and PGF ( 2 ) receptor ( FP ) , efficiently *blocked* LPS induced [tumor necrosis factor a (TNFa)] synthesis and COX-2 and mPGES-1 induction as well as prostaglandin synthesis in spinal cultures . Negative_regulation TNF PTGS1 11982590 935353 NS398 , a specific COX-2 inhibitor , and indomethacin ( IM ) , a and COX-2 inhibitor , *enhanced* viable BCG induced cytotoxic activity and IFN-gamma and [TNF-alpha] production of PEC . Negative_regulation TNF PTGS2 11982590 935354 NS398 , a specific COX-2 inhibitor , and indomethacin ( IM ) , a COX-1 and inhibitor , *enhanced* viable BCG induced cytotoxic activity and IFN-gamma and [TNF-alpha] production of PEC . Negative_regulation TNF PTGS2 18068105 1846995 The JAK3 inhibitor had no effect on expression , and [TNF-alpha] production was slightly *inhibited* only at higher drug concentrations ( 30 microM ) . Negative_regulation TNF PTGS2 19123332 2004912 PrG ( 40 mg x kg ( -1 ) d ( -1 ) ) could decrease the serum level of inflammatory factor [TNF-alpha] , and slightly *inhibit* and ICAM-1 protein expression in ischemic myocardium of AMI rats . Negative_regulation TNF PTGS2 20022932 2200238 inhibition by NS-398 *enhanced* IL-6 and [TNF-alpha] expression and IL-6 protein secretion induced by palmitate . Negative_regulation TNF PTGS2 22303922 2668271 SPEE treatment significantly inhibited the LPS induced production of NO , prostaglandin E ( 2 ) , interleukin-6 , and [tumor necrosis factor-a] and *inhibited* the expression of iNOS and via attenuation of NF-?B p65 expression . Negative_regulation TNF PTGS2 22418033 2582633 Danshensu partly blocked the expression of RAGE , p-p38 , and , and NF-?B activation , and *inhibited* the increase of [TNF-a] , IL-6 , and PGE2 . Negative_regulation TNF PTGS2 23646479 2779663 Polydatin improved the sepsis induced mortality dose-dependently , *inhibited* increased ALT , AST activity and [TNF-alpha] , decreased the hepatic protein expression , and attenuated the pathological injury of the liver ( P < 0.05 ) . Negative_regulation TNF PTK2 11821008 908852 FITC-dextran-10K ) during superfusion with vehicle , tumor necrosis factor ( TNF-alpha ; 10 ng/ml ) , [TNF-alpha] in the presence of an inhibitor of soluble guanylate cyclase ( ODQ ; 1.0 microM ) , and TNF-alpha in the *presence* of an inhibitor of ( genistein ; 10 microM ) . Negative_regulation TNF PTK2 14715932 1197416 Together , these findings indicate that both ERK and JNK are involved in the regulation of [TNF] mRNA expression , that p38 is involved in the nucleocytoplasmic transport of TNF mRNA , and that a ( protein tyrosine kinase ) , possibly a member of the src family , *acts* downstream of the P2X7 receptor to activate JNK and p38 . Negative_regulation TNF PTK6 11821008 908853 FITC-dextran-10K ) during superfusion with vehicle , tumor necrosis factor ( TNF-alpha ; 10 ng/ml ) , TNF-alpha in the presence of an inhibitor of soluble guanylate cyclase ( ODQ ; 1.0 microM ) , and [TNF-alpha] in the *presence* of an inhibitor of ( genistein ; 10 microM ) . Negative_regulation TNF PTK6 14715932 1197417 Together , these findings indicate that both ERK and JNK are involved in the regulation of [TNF] mRNA expression , that p38 is involved in the nucleocytoplasmic transport of TNF mRNA , and that a ( protein tyrosine kinase ) , possibly a member of the src family , *acts* downstream of the P2X7 receptor to activate JNK and p38 . Negative_regulation TNF PTK7 11821008 908854 FITC-dextran-10K ) during superfusion with vehicle , [tumor necrosis factor] ( TNF-alpha ; 10 ng/ml ) , TNF-alpha in the presence of an inhibitor of soluble guanylate cyclase ( ODQ ; 1.0 microM ) , and TNF-alpha in the *presence* of an inhibitor of ( genistein ; 10 microM ) . Negative_regulation TNF PTK7 14715932 1197418 Together , these findings indicate that both ERK and JNK are involved in the regulation of [TNF] mRNA expression , that p38 is involved in the nucleocytoplasmic transport of TNF mRNA , and that a ( protein tyrosine kinase ) , possibly a member of the src family , *acts* downstream of the P2X7 receptor to activate JNK and p38 . Negative_regulation TNF PTPN22 19274442 2072830 3 ( LRENECVS ) which was derived from the hydrophilic region of A1 module in CRD4 remarkably *inhibited* the binding of [TNF-alpha] to TNF-R1 , and also reversed TNF-alpha induced degradation of IkappaB-alpha and nuclear translocation of NF-kappaB p65 subunit in HeLa cells . Negative_regulation TNF PTPN6 16487932 1528514 *inhibits* LPS mediated [TNF] and iNOS production in murine macrophages . Negative_regulation TNF PTPN6 16487932 1528517 Herein we report that the repressible/inducible over-expression of wild-type in a subclone of RAW 264.7 macrophages ( RAW-TT10 cells ) *inhibited* both [TNF] secretion and iNOS protein accumulation in response to stimulation with lipopolysaccharide (LPS) and recombinant murine interferon-gamma and led to diminished LPS mediated tyrosine phosphorylation of vav1 . Negative_regulation TNF PTPN6 22077594 2514006 The expression of the mutant form of which was unable to interact with 3BP2 *resulted* in the significant reduction in SHP-1 mediated [tumor necrosis factor-a (TNF-a)] production without any effects on the degranulation in antigen stimulated RBL-2H3 cells . Negative_regulation TNF PTPRC 11342620 812806 Costimulation with OKT-3 and IL-2 optimally *induced* secretion of IFN-gamma , [TNF-alpha] , and IL-5 , which was not decreased by signals . Negative_regulation TNF PTPRC 8766549 374988 ligation *resulted* in [TNF-alpha] secretion . Negative_regulation TNF PTX3 10363654 620189 is a very inexpensive xanthine derivative , which is widely used in humans as a haemorheological agent , and *inhibits* [tumor necrosis factor] transcription . Negative_regulation TNF PTX3 10464849 640529 The [TNF-alpha] production by AM was significantly suppressed in the *presence* of at concentrations of 2.0 and 1.0 mM , while production of IL-1 beta , IL-6 and GM-CSF remained unaffected . Negative_regulation TNF PTX3 10464849 640531 In PBM cultures , significantly *suppressed* the production of [TNF-alpha] and GM-CSF , at all tested concentrations . Negative_regulation TNF PTX3 10464849 640535 The present study provides evidence that selectively *suppresses* the production of [TNF-alpha] by LPS stimulated AM and may have a role in the treatment of lung diseases where TNF-alpha is involved . Negative_regulation TNF PTX3 10996031 733699 We have found that , at concentrations below 100 microg/ml , selectively *inhibited* the production of [TNF-alpha] . Negative_regulation TNF PTX3 10996031 733701 However , at higher concentrations , *inhibited* the production of [TNF-alpha] , IL-10 , and IL-12 p35 , but surprisingly , PTX enhanced the production of IL-12 p40 . Negative_regulation TNF PTX3 11080076 749563 To improve our understanding of the role that these two cytokines serve in mediating infection during anorexia , we investigated the ability of , a potent *inhibitor* of [TNF-alpha] production , to block the anorectic effects of the bacterial products lipopolysaccharide (LPS) and muramyl dipeptide ( MDP ) in rats . Negative_regulation TNF PTX3 11113085 757694 An earlier pilot study from our liver unit suggested benefit from treatment with , an *inhibitor* of [tumor necrosis factor (TNF)] , in severe acute alcoholic hepatitis . Negative_regulation TNF PTX3 11301047 803307 completely *inhibited* LPS induced [TNF-alpha] production and attenuated IL-6 only after 48 hr of incubation . Negative_regulation TNF PTX3 11875767 893787 *inhibited* production of NO ( IC50 approximately equal to 1.0 mg/ml ) and [TNF-alpha] ( IC50 approximately equal to 0.05 mg/ml ) in a dose dependent fashion . Negative_regulation TNF PTX3 12030348 947605 in vitro could suppress T cell proliferation and *inhibit* [TNF-alpha] and interferon-gamma production . Negative_regulation TNF PTX3 1385797 190871 In this system , was found to *inhibit* the secretion of both [TNF-alpha] and IL-6 by T cells . Negative_regulation TNF PTX3 15060681 1230526 While indo and ibu treatment resulted in increased TNF production , , VZ 65 , and AA-861 significantly *inhibited* [TNF] production , whether administered simultaneously with LPS or 30 min after LPS treatment . Negative_regulation TNF PTX3 15060681 1230528 We conclude that while *reduced* [TNF] protein levels by inhibiting TNF mRNA transcription , both VZ 65 and AA-861 exerted opposing effects on TNF transcription and increased mRNA stability . Negative_regulation TNF PTX3 15213357 1262729 Therefore , the aim of our present study was to determine the action of , an *inhibitor* of [tumor necrosis factor alpha (TNFalpha)] with or without NOS inhibition by L-NNA administration in rats with water immersion and restraint stress ( WRS ) -induced gastric lesions . Negative_regulation TNF PTX3 15648785 1350034 At all dosages , *reduced* the activation of NF-kappaB and the production of [TNF-alpha] and IL-6 , but enhanced the release of IL-10 . Negative_regulation TNF PTX3 15648785 1350044 In conclusion , *suppressed* the production of proinflammatory cytokines such as [TNF-alpha] and IL-6 in rat intestine , and enhanced the endotoxin induced production of IL-10 . Negative_regulation TNF PTX3 1596574 188749 DEX and *reduced* the acivicin induced increases in [TNF-alpha] and IL-1 beta mRNA expression , but they had little or no effect on the acivicin induced decreases in expression of mRNA for c-myc and c-myb . Negative_regulation TNF PTX3 1596574 188753 Thus , DEX and effectively *block* the acivicin induced expression of [TNF-alpha] and IL-1 beta , but they have little influence on the acivicin induced differentiation process . Negative_regulation TNF PTX3 17110505 1700493 , a phosphodiesterase and nonspecific [TNF-alpha] *inhibitor* , ameliorates experimental HPS when begun before hepatic injury . Negative_regulation TNF PTX3 17198087 1680586 significantly *reduced* the production of [TNF-alpha] and IFN-gamma in mature DCs ( mDCs ) . Negative_regulation TNF PTX3 17692605 1782031 In conclusion , *inhibits* liver [TNFalpha] gene transcription , decreases serum TNFalpha levels , and reduces liver injury following normothermic I-R . Negative_regulation TNF PTX3 18242889 1864992 However , aminoguanidine ( AG ) , a selective inhibitor of inducible nitric oxide synthase (iNOS) , and , an *inhibitor* of [tumor necrosis factor alpha (TNF-alpha)] synthesis , had no effect on LPS induced upregulation of HO-1 in fetal liver . Negative_regulation TNF PTX3 1833865 167181 In vitro experiments on human peripheral blood leukocytes indicated that alone or in synergy with methylprednisolone ( m-PDS ) also *inhibited* the release of [TNF] and IL-2 induced by OKT3 . Negative_regulation TNF PTX3 19321979 2094053 Renal [TNF-alpha] release was significantly *reduced* by URO 20 microg/l ( from 178 +/- 23 to 45.2 +/- 2 and 47 +/- 3 pg/ml ) in the E. coli + URO 20 microg/l and by in the E. coli + PTX group if added to the perfusion medium upon start of perfusion . Negative_regulation TNF PTX3 19617639 2112444 As expected , *reduced* also production of [TNF] . Negative_regulation TNF PTX3 19617639 2112450 *inhibits* production of [TNF] and may decrease inflammatory reaction both in vitro and in vivo , but these effects are independent of HO-1 . Negative_regulation TNF PTX3 21037437 2339067 Recent experimental data suggest that , a [tumor necrosis factor (TNF)] a *inhibitor* , enhances liver regeneration and reduces ischemic injury through activation of the interleukin-6 (IL-6) signaling pathway . Negative_regulation TNF PTX3 21167055 2358191 In this model , the effect of a very low dose of LA ( 0.1 mg/kg ) was potentiated by the same dose of , a known [TNF-alpha] *inhibitor* . Negative_regulation TNF PTX3 21167055 2358193 Furthermore , the LA effect was potentiated by ( a [TNF-alpha] *inhibitor* ) . Negative_regulation TNF PTX3 21219888 2386439 To further investigate whether TNF-a would play a role in brain edema formation , we examined the effects of pentoxifylline ( , an *inhibitor* of [TNF-a] synthesis ) on the brain edema and TNF-a levels in a model of transient focal cerebral ischemia . Negative_regulation TNF PTX3 23911669 2835777 The increased levels of [TNF-a] and IL-17 in periarticular tissues of AIA mice were also *reduced* by both treatments . Negative_regulation TNF PTX3 7578989 333407 In addition to the *induced* decrease of [TNF] production , these effects on PMN could be beneficial in pathological conditions where high TNF production may induce excessive PMN activation , leading to vascular damage and tissue injury . Negative_regulation TNF PTX3 7593465 336365 *Inhibitors* of [TNF] synthesis , and thalidomide , inhibited TNF mRNA accumulation in LPS activated monocytes and down-regulated DR mRNA but not DP or DQ mRNA . Negative_regulation TNF PTX3 8116037 246416 The hemorrheologic agent *inhibits* the synthesis of [TNF alpha] in vitro in response to a variety of stimuli , including OKT3 . Negative_regulation TNF PTX3 8132735 251609 Because *inhibits* [TNF-alpha] synthesis and secretion in monocytes , we hypothesized that PTX may also inhibit TNF-alpha secretion by NK cells and thus would inhibit IL-2 mediated activation of free cells . Negative_regulation TNF PTX3 8132735 251611 IL-2 mediated secretion of [TNF-alpha] by the free cells was *inhibited* by . Negative_regulation TNF PTX3 8132735 251614 Also , *inhibited* IL-2 triggered upregulation of the expression of CD69 , CD25 , ICAM-1 , and [p75TNF-R] on the cell surface . Negative_regulation TNF PTX3 8132735 251622 These findings demonstrate that PTX has a marked suppression on IL-2 mediated activation of immature free NK cells and that the suppression is due , in large part , to mediated *inhibition* of endogenous [TNF-alpha] secretion . Negative_regulation TNF PTX3 8189599 258600 *suppressed* [TNF-alpha] gene transcription and downregulates the expression of TNF-alpha mRNA and the secretion of TNF-alpha protein in macrophages and monocytes . Negative_regulation TNF PTX3 8485822 218958 The phosphodiesterase inhibitor *inhibits* [TNF] gene transcription and modulates PMN function , and has been shown to improve outcome in experimental sepsis . Negative_regulation TNF PTX3 8485822 218960 Peak serum [TNF] in CA + NSS animals ( 130 +/- 45 U/ml ) was delayed 8 hr compared to EC animals , and were not *reduced* by ( 67 +/- 25 U/ml , P = NS ) . Negative_regulation TNF PTX3 8485822 218962 We conclude that *induced* suppression of endogenous [TNF] production does not prevent gram negative shock in this model , possibly due to impaired TNF mediated antibacterial host defense . Negative_regulation TNF PTX3 8579638 342209 When peripheral white blood cells were stimulated with either E. coli lipopolysaccharide (LPS) or Staphylococcus aureus , *inhibited* [TNF] production . Negative_regulation TNF PTX3 8579638 342211 *inhibited* not only the [TNF] production of monocytes , but also the TNF secretion of both granulocytes and unseparated whole blood . Negative_regulation TNF PTX3 8585982 341451 , a phosphodiesterase inhibitor , significantly *attenuated* [TNF alpha] release caused either by Streptococcus pneumoniae or by its lysates . Negative_regulation TNF PTX3 8585982 341453 It was found that significantly *attenuated* [TNF alpha] activity in serum and bronchoalveolar lavage fluid , and inhibited white blood cell chemotaxis , emigration and infiltration . Negative_regulation TNF PTX3 9058776 417688 *caused* a significant suppression of spontaneous production of [TNF-alpha] by cultured PBMC of HAM patients . Negative_regulation TNF PTX3 9143734 428658 Previous studies have demonstrated that can *suppress* [TNF alpha] production and function , and can inhibit the adhesion of neutrophils and monocytes to endothelial cells . Negative_regulation TNF PTX3 9168405 432629 at a 3.5 x 10 ( -5 ) M concentration significantly *inhibited* T cell proliferation and the production of [tumor necrosis factor-alpha] , interleukin-2 , and interleukin-4 . Negative_regulation TNF PTX3 9172017 407016 Our results showed that expression and production of [TNF alpha] and TNF beta were *inhibited* by in a dose dependent manner . Negative_regulation TNF PTX3 9176074 433628 *inhibited* the release of [TNF-alpha] by PBMCs from patients with inflammatory bowel disease and the secretion of TNF-alpha and IL-1 beta by organ cultures of inflamed mucosa from the same patients . Negative_regulation TNF PTX3 9486396 488342 These data suggest that *inhibits* [TNF-alpha] production in ENL patients both in vivo and in vitro , and it may be useful in the treatment of leprosy patients undergoing ENL . Negative_regulation TNF PTX4 10363654 620188 is a very inexpensive xanthine derivative , which is widely used in humans as a haemorheological agent , and *inhibits* [tumor necrosis factor] transcription . Negative_regulation TNF PTX4 10464849 640528 The [TNF-alpha] production by AM was significantly suppressed in the *presence* of at concentrations of 2.0 and 1.0 mM , while production of IL-1 beta , IL-6 and GM-CSF remained unaffected . Negative_regulation TNF PTX4 10464849 640530 In PBM cultures , significantly *suppressed* the production of [TNF-alpha] and GM-CSF , at all tested concentrations . Negative_regulation TNF PTX4 10464849 640534 The present study provides evidence that selectively *suppresses* the production of [TNF-alpha] by LPS stimulated AM and may have a role in the treatment of lung diseases where TNF-alpha is involved . Negative_regulation TNF PTX4 10996031 733698 We have found that , at concentrations below 100 microg/ml , selectively *inhibited* the production of [TNF-alpha] . Negative_regulation TNF PTX4 10996031 733700 However , at higher concentrations , *inhibited* the production of [TNF-alpha] , IL-10 , and IL-12 p35 , but surprisingly , PTX enhanced the production of IL-12 p40 . Negative_regulation TNF PTX4 11080076 749562 To improve our understanding of the role that these two cytokines serve in mediating infection during anorexia , we investigated the ability of , a potent *inhibitor* of [TNF-alpha] production , to block the anorectic effects of the bacterial products lipopolysaccharide (LPS) and muramyl dipeptide ( MDP ) in rats . Negative_regulation TNF PTX4 11113085 757693 An earlier pilot study from our liver unit suggested benefit from treatment with , an *inhibitor* of [tumor necrosis factor (TNF)] , in severe acute alcoholic hepatitis . Negative_regulation TNF PTX4 11301047 803306 completely *inhibited* LPS induced [TNF-alpha] production and attenuated IL-6 only after 48 hr of incubation . Negative_regulation TNF PTX4 11875767 893786 *inhibited* production of NO ( IC50 approximately equal to 1.0 mg/ml ) and [TNF-alpha] ( IC50 approximately equal to 0.05 mg/ml ) in a dose dependent fashion . Negative_regulation TNF PTX4 12030348 947604 in vitro could suppress T cell proliferation and *inhibit* [TNF-alpha] and interferon-gamma production . Negative_regulation TNF PTX4 1385797 190870 In this system , was found to *inhibit* the secretion of both [TNF-alpha] and IL-6 by T cells . Negative_regulation TNF PTX4 15060681 1230525 While indo and ibu treatment resulted in increased TNF production , , VZ 65 , and AA-861 significantly *inhibited* [TNF] production , whether administered simultaneously with LPS or 30 min after LPS treatment . Negative_regulation TNF PTX4 15060681 1230527 We conclude that while *reduced* [TNF] protein levels by inhibiting TNF mRNA transcription , both VZ 65 and AA-861 exerted opposing effects on TNF transcription and increased mRNA stability . Negative_regulation TNF PTX4 15213357 1262728 Therefore , the aim of our present study was to determine the action of , an *inhibitor* of [tumor necrosis factor alpha (TNFalpha)] with or without NOS inhibition by L-NNA administration in rats with water immersion and restraint stress ( WRS ) -induced gastric lesions . Negative_regulation TNF PTX4 15648785 1350033 At all dosages , *reduced* the activation of NF-kappaB and the production of [TNF-alpha] and IL-6 , but enhanced the release of IL-10 . Negative_regulation TNF PTX4 15648785 1350043 In conclusion , *suppressed* the production of proinflammatory cytokines such as [TNF-alpha] and IL-6 in rat intestine , and enhanced the endotoxin induced production of IL-10 . Negative_regulation TNF PTX4 1596574 188748 DEX and *reduced* the acivicin induced increases in [TNF-alpha] and IL-1 beta mRNA expression , but they had little or no effect on the acivicin induced decreases in expression of mRNA for c-myc and c-myb . Negative_regulation TNF PTX4 1596574 188752 Thus , DEX and effectively *block* the acivicin induced expression of [TNF-alpha] and IL-1 beta , but they have little influence on the acivicin induced differentiation process . Negative_regulation TNF PTX4 17110505 1700492 , a phosphodiesterase and nonspecific [TNF-alpha] *inhibitor* , ameliorates experimental HPS when begun before hepatic injury . Negative_regulation TNF PTX4 17198087 1680585 significantly *reduced* the production of [TNF-alpha] and IFN-gamma in mature DCs ( mDCs ) . Negative_regulation TNF PTX4 17692605 1782030 In conclusion , *inhibits* liver [TNFalpha] gene transcription , decreases serum TNFalpha levels , and reduces liver injury following normothermic I-R . Negative_regulation TNF PTX4 18242889 1864991 However , aminoguanidine ( AG ) , a selective inhibitor of inducible nitric oxide synthase (iNOS) , and , an *inhibitor* of [tumor necrosis factor alpha (TNF-alpha)] synthesis , had no effect on LPS induced upregulation of HO-1 in fetal liver . Negative_regulation TNF PTX4 1833865 167180 In vitro experiments on human peripheral blood leukocytes indicated that alone or in synergy with methylprednisolone ( m-PDS ) also *inhibited* the release of [TNF] and IL-2 induced by OKT3 . Negative_regulation TNF PTX4 19321979 2094052 Renal [TNF-alpha] release was significantly *reduced* by URO 20 microg/l ( from 178 +/- 23 to 45.2 +/- 2 and 47 +/- 3 pg/ml ) in the E. coli + URO 20 microg/l and by in the E. coli + PTX group if added to the perfusion medium upon start of perfusion . Negative_regulation TNF PTX4 19617639 2112443 As expected , *reduced* also production of [TNF] . Negative_regulation TNF PTX4 19617639 2112449 *inhibits* production of [TNF] and may decrease inflammatory reaction both in vitro and in vivo , but these effects are independent of HO-1 . Negative_regulation TNF PTX4 21037437 2339066 Recent experimental data suggest that , a [tumor necrosis factor (TNF)] a *inhibitor* , enhances liver regeneration and reduces ischemic injury through activation of the interleukin-6 (IL-6) signaling pathway . Negative_regulation TNF PTX4 21167055 2358190 In this model , the effect of a very low dose of LA ( 0.1 mg/kg ) was potentiated by the same dose of , a known [TNF-alpha] *inhibitor* . Negative_regulation TNF PTX4 21167055 2358192 Furthermore , the LA effect was potentiated by ( a [TNF-alpha] *inhibitor* ) . Negative_regulation TNF PTX4 21219888 2386438 To further investigate whether TNF-a would play a role in brain edema formation , we examined the effects of pentoxifylline ( , an *inhibitor* of [TNF-a] synthesis ) on the brain edema and TNF-a levels in a model of transient focal cerebral ischemia . Negative_regulation TNF PTX4 23911669 2835776 The increased levels of [TNF-a] and IL-17 in periarticular tissues of AIA mice were also *reduced* by both treatments . Negative_regulation TNF PTX4 7578989 333406 In addition to the *induced* decrease of [TNF] production , these effects on PMN could be beneficial in pathological conditions where high TNF production may induce excessive PMN activation , leading to vascular damage and tissue injury . Negative_regulation TNF PTX4 7593465 336364 *Inhibitors* of [TNF] synthesis , and thalidomide , inhibited TNF mRNA accumulation in LPS activated monocytes and down-regulated DR mRNA but not DP or DQ mRNA . Negative_regulation TNF PTX4 8116037 246415 The hemorrheologic agent *inhibits* the synthesis of [TNF alpha] in vitro in response to a variety of stimuli , including OKT3 . Negative_regulation TNF PTX4 8132735 251608 Because *inhibits* [TNF-alpha] synthesis and secretion in monocytes , we hypothesized that PTX may also inhibit TNF-alpha secretion by NK cells and thus would inhibit IL-2 mediated activation of free cells . Negative_regulation TNF PTX4 8132735 251610 IL-2 mediated secretion of [TNF-alpha] by the free cells was *inhibited* by . Negative_regulation TNF PTX4 8132735 251613 Also , *inhibited* IL-2 triggered upregulation of the expression of CD69 , CD25 , ICAM-1 , and [p75TNF-R] on the cell surface . Negative_regulation TNF PTX4 8132735 251621 These findings demonstrate that PTX has a marked suppression on IL-2 mediated activation of immature free NK cells and that the suppression is due , in large part , to *mediated* inhibition of endogenous [TNF-alpha] secretion . Negative_regulation TNF PTX4 8189599 258599 *suppressed* [TNF-alpha] gene transcription and downregulates the expression of TNF-alpha mRNA and the secretion of TNF-alpha protein in macrophages and monocytes . Negative_regulation TNF PTX4 8485822 218957 The phosphodiesterase inhibitor *inhibits* [TNF] gene transcription and modulates PMN function , and has been shown to improve outcome in experimental sepsis . Negative_regulation TNF PTX4 8485822 218959 Peak serum [TNF] in CA + NSS animals ( 130 +/- 45 U/ml ) was delayed 8 hr compared to EC animals , and were not *reduced* by ( 67 +/- 25 U/ml , P = NS ) . Negative_regulation TNF PTX4 8485822 218961 We conclude that *induced* suppression of endogenous [TNF] production does not prevent gram negative shock in this model , possibly due to impaired TNF mediated antibacterial host defense . Negative_regulation TNF PTX4 8579638 342208 When peripheral white blood cells were stimulated with either E. coli lipopolysaccharide (LPS) or Staphylococcus aureus , *inhibited* [TNF] production . Negative_regulation TNF PTX4 8579638 342210 *inhibited* not only the [TNF] production of monocytes , but also the TNF secretion of both granulocytes and unseparated whole blood . Negative_regulation TNF PTX4 8585982 341450 , a phosphodiesterase inhibitor , significantly *attenuated* [TNF alpha] release caused either by Streptococcus pneumoniae or by its lysates . Negative_regulation TNF PTX4 8585982 341452 It was found that significantly *attenuated* [TNF alpha] activity in serum and bronchoalveolar lavage fluid , and inhibited white blood cell chemotaxis , emigration and infiltration . Negative_regulation TNF PTX4 9058776 417687 *caused* a significant suppression of spontaneous production of [TNF-alpha] by cultured PBMC of HAM patients . Negative_regulation TNF PTX4 9143734 428657 Previous studies have demonstrated that can *suppress* [TNF alpha] production and function , and can inhibit the adhesion of neutrophils and monocytes to endothelial cells . Negative_regulation TNF PTX4 9168405 432628 at a 3.5 x 10 ( -5 ) M concentration significantly *inhibited* T cell proliferation and the production of [tumor necrosis factor-alpha] , interleukin-2 , and interleukin-4 . Negative_regulation TNF PTX4 9172017 407015 Our results showed that expression and production of [TNF alpha] and TNF beta were *inhibited* by in a dose dependent manner . Negative_regulation TNF PTX4 9176074 433627 *inhibited* the release of [TNF-alpha] by PBMCs from patients with inflammatory bowel disease and the secretion of TNF-alpha and IL-1 beta by organ cultures of inflamed mucosa from the same patients . Negative_regulation TNF PTX4 9486396 488341 These data suggest that *inhibits* [TNF-alpha] production in ENL patients both in vivo and in vitro , and it may be useful in the treatment of leprosy patients undergoing ENL . Negative_regulation TNF QRICH1 12507630 1038433 *attenuates* [tumor necrosis factor-alpha] release and enhances heat shock protein 72 in human peripheral blood mononuclear cells . Negative_regulation TNF QRICH1 18807160 1969833 *reduces* [TNF-alpha] by enhancing glutathione synthesis in lipopolysaccharide stimulated alveolar epithelial cells of rats . Negative_regulation TNF QRICH1 18807160 1969835 As a precursor of GSH , could prevent the NF-kappaB activation and *attenuate* the release of [TNF-alpha] in LPS stimulated AT-II cells and the effect may be mediated via GSH synthesis . Negative_regulation TNF QRICH1 20400787 2181450 and alanyl-glutamine dipeptide *reduce* mesenteric plasma extravasation , leukocyte adhesion and [tumor necrosis factor-a (TNF-a)] release during experimental endotoxemia . Negative_regulation TNF QRICH1 23498057 2761102 Our investigations showed for the first time in whole blood probes , imitating best physiologically present cellular interactions , that *caused* a dose independent inhibitory effect on IL-6 and [TNF-a] production in human monocytes stimulated with LPS . Negative_regulation TNF QRICH2 12507630 1038434 *attenuates* [tumor necrosis factor-alpha] release and enhances heat shock protein 72 in human peripheral blood mononuclear cells . Negative_regulation TNF QRICH2 18807160 1969834 *reduces* [TNF-alpha] by enhancing glutathione synthesis in lipopolysaccharide stimulated alveolar epithelial cells of rats . Negative_regulation TNF QRICH2 18807160 1969836 As a precursor of GSH , could prevent the NF-kappaB activation and *attenuate* the release of [TNF-alpha] in LPS stimulated AT-II cells and the effect may be mediated via GSH synthesis . Negative_regulation TNF QRICH2 20400787 2181451 Glutamine and dipeptide *reduce* mesenteric plasma extravasation , leukocyte adhesion and [tumor necrosis factor-a (TNF-a)] release during experimental endotoxemia . Negative_regulation TNF QRICH2 23498057 2761103 Our investigations showed for the first time in whole blood probes , imitating best physiologically present cellular interactions , that *caused* a dose independent inhibitory effect on IL-6 and [TNF-a] production in human monocytes stimulated with LPS . Negative_regulation TNF RAB37 21805469 2495249 Overexpression of wild type and constitutively active in RAW264.7 cells significantly *increased* [TNF-a] secretion , whereas knockdown of Rab37 by siRNA significantly decreased it . Negative_regulation TNF RAB8A 24409409 2900672 Also , up-regulated Bcl2 expression and *down-regulated* [TNF-a] expression compared with EPO . Negative_regulation TNF RABEPK 9310830 454990 In addition , cross linking of molecules strongly *inhibited* the CD94 induced [tumor necrosis factor-alpha] and IFN-gamma production . Negative_regulation TNF RAC1 11402028 842914 Expression of a dominant negative mutant of ( N17Rac1 ) *reduced* Rac1 activation , ROS formation , NFkappaB activation , and [TNFalpha] secretion following LPS stimulation . Negative_regulation TNF RAC1 14555937 1153207 Furthermore , *suppressed* NF-kappaB activation and messenger RNA expression of [tumor necrosis factor-alpha (TNF-alpha)] and inducible nitric oxide synthetase (iNOS) . Negative_regulation TNF RAC1 19450605 2096910 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 MAPK and inhibited cardiac TNF-alpha expression induced by LPS , suggesting an important *role* of and estrogen in LPS stimulated [TNF-alpha] expression in the heart . Negative_regulation TNF RAC1 19473519 2091151 [TNF-alpha] *induced* phosphorylation of Rac , while atorvastatin and Rac-1 inhibitor inhibited the phosphorylation of induced by TNF-alpha . Negative_regulation TNF RAC1 20518848 2430852 The aim of this study was to investigate the *role* of in [TNF-a] expression and cardiac dysfunction during endotoxemia and to determine the involvement of phosphoinositide-3 kinase (PI3K) in lipopolysaccharide (LPS) induced Rac1 activation . Negative_regulation TNF RAC2 19473519 2091152 [TNF-alpha] *induced* phosphorylation of Rac , while atorvastatin and Rac-1 inhibitor inhibited the phosphorylation of induced by TNF-alpha . Negative_regulation TNF RAC3 19473519 2091153 [TNF-alpha] *induced* phosphorylation of Rac , while atorvastatin and Rac-1 inhibitor inhibited the phosphorylation of induced by TNF-alpha . Negative_regulation TNF RAMP1 15245870 1270944 [TNF-alpha] *induced* time- and dose dependent decreases in the expression of CRLR and mRNAs , thereby diminishing AM-evoked cAMP production . Negative_regulation TNF RANBP2 8468478 216119 These observations , coupled with the finding that 15669 does not *inhibit* endotoxin induced [TNF] release suggest that inhibition of leukocyte sequestration can increase survival after endotoxin challenge , and that NPC 15669 or antibodies to Mac-1 may represent effective therapies for gram negative sepsis and shock . Negative_regulation TNF RAPGEF1 20309718 2299863 BAY 11-7082 treatment abolished *induced* reduction of [TNFalpha] and IL-6 . Negative_regulation TNF RAPGEF1 24841888 2940234 Our results showed that *attenuated* lung histopathologic changes , myeloperoxidase (MPO) activity , [TNF-a] , IL-1ß and IL-6 production in LPS induced acute lung injury model . Negative_regulation TNF RAPGEF1 24841888 2940238 In vitro , dose-dependently *inhibited* [TNF-a] , IL-1ß , IL-6 , IL-10 and IFN-ß production , as well as NF-?B and IRF3 activation in LPS stimulated alveolar macrophages . Negative_regulation TNF RAPGEF3 15634874 1362601 By contrast , activation of PKA , but not , *suppressed* AM production of leukotriene B ( 4 ) and [TNF-alpha] , whereas stimulation of either PKA or Epac-1 inhibited AM bactericidal activity and H ( 2 ) O ( 2 ) production . Negative_regulation TNF RB1 25206809 2958131 Additionally , ginsenoside *inhibited* levels of [tumor necrosis factor-a] in a co-culture system containing activated N9 microglial cells . Negative_regulation TNF RBCK1 17449468 1749617 Overexpression of negatively *regulates* TAB2/3 mediated and [TNF-] and IL-1 induced NF-kappaB activation , whereas knockdown of RBCK1 by RNA interference potentiates TNF- and IL-1 induced NF-kappaB activation . Negative_regulation TNF RBL2 11345690 814232 Rb1 , and strongly *suppressed* [TNF-alpha] production in RAW264.7 cells with an IC50 of 56.5 and 27.5 microM , respectively , and in differentiated U937 cells with an IC50 of 51.3 , and 26.8 microM , respectively . Negative_regulation TNF RBM10 23675440 2785300 Moreover , also *attenuated* protein expression of cathepsin K , matrix metalloproteinases-9 (MMP-9) , tartrate-resistant acid phosphatase ( TRAP ) , and [tumor necrosis factor-a (TNF-a)] in ankle tissues of AIA-rats . Negative_regulation TNF RBMS1 15886813 1406880 Furthermore , several mediators were detected and the data showed that profoundly *blocked* LPS induced NO as well as [TNF-alpha] production , and prevented lung damage by histological examination . Negative_regulation TNF RELA 10203355 606163 Cells were stimulated with [TNF-alpha] or LPS plus IFN-gamma in the *presence* of inhibitors , herbimycin A (HerA) , or the more specific JAK2 inhibitor AG490 . Negative_regulation TNF RELA 10416612 631437 In UM-SCC-9 cells that stably expressed IkappaBalphaM , inhibition of constitutive and [tumor necrosis factor-a] *induced* activation , and production of all four cytokines was observed . Negative_regulation TNF RELA 10486238 644706 *Role* of transcription factor in asbestos induced [TNFalpha] response from macrophages . Negative_regulation TNF RELA 10486238 644712 Inhibition of by SN50 , an inhibitor of NF-kappaB nuclear translocation , or by sequence-specific oligonucleotides directed against the NF-kappaB binding site of TNFalpha promoter *attenuated* the asbestos effect on [TNFalpha] production . Negative_regulation TNF RELA 10497896 647557 This is supported by evidence that inhibition of activation by SN50 , a specific NF-kappaB inhibitor , *resulted* in a decrease in the [TNFalpha] production . Negative_regulation TNF RELA 10893342 711472 These results suggest that [TNF-alpha] inhibition of hormone stimulated transcriptional activation may be *mediated* by activation of . Negative_regulation TNF RELA 10896870 711830 Here we tested the hypothesis that hypoxic suppression of postbacteremic [TNF-alpha] gene expression is transcriptionally *mediated* by reduced activation of . Negative_regulation TNF RELA 10924061 718163 Finally , inhibition of ERK phosphorylation reduced , and nuclear translocation *prevented* , [tumor necrosis factor-alpha] production . Negative_regulation TNF RELA 10959811 726327 Pretreatment of rats with DDB prevented LPS induced hepatic I-kappaBalpha degradation and the resultant activation , and *inhibited* the LPS induced plasma TNF-alpha protein and hepatic [TNF-alpha] mRNA expression in a dose dependent manner . Negative_regulation TNF RELA 11522776 868718 We demonstrate here that the cell differentiation dependent reduction of [TNFalpha] stimulation is not *due* to insufficient activation but correlates with increased synthesis of the monocyte differentiation associated factors CCAAT/enhancer binding protein (C/EBP) alpha and beta . Negative_regulation TNF RELA 11571308 882351 The antigen presenting capacity of [TNF-alpha] stimulated CD34 ( + ) cells was strongly *inhibited* by ICOSIg fusion proteins or by inhibition . Negative_regulation TNF RELA 11576850 865180 TNF was measured by an enzyme linked immunosorbent assay after 8 h , and induction by electrophoretic mobility shift assays ( EMSA ) after 2 h. DMXAA ( 800 microg/ml ) had no effect alone on TNF production but *augmented* , by up to 4-fold , the ability of bacterial lipopolysaccharide (LPS) to induce [TNF] . Negative_regulation TNF RELA 11676830 873542 These results indicate that interferon-gamma and [TNF-alpha] synergistically *induce* keratinocyte apoptosis when concomitant induction of is blocked . Negative_regulation TNF RELA 11948689 930242 Conversely , expression of the p65 subunit of *suppressed* [TNF-alpha-] , TRAIL- , and serum deprivation induced cell death . Negative_regulation TNF RELA 11991979 938616 Inhibition of [tumor necrosis factor] alpha *induced* activation by the adenovirus E3-10.4/14.5K complex . Negative_regulation TNF RELA 12133965 967049 Here we investigate the *role* of mitogen activated protein kinases ( MAPKs ) and in [TNF-alpha] production by human monocytes stimulated with GBS or LPS , used as a positive control . Negative_regulation TNF RELA 12174385 974523 sCCK-8 *inhibits* LPS induced [TNF-alpha] mRNA expression by regulating activity in rat PIMs , which is mediated through CCK receptors and inhibiting IkappaB-alpha degradation . Negative_regulation TNF RELA 12175093 974552 Ketamine significantly reduced the LPS induced activation and *inhibited* [TNFalpha] production in a dose dependent manner . Negative_regulation TNF RELA 12203103 983117 The *role* of in enhancement of [TNF-alpha] production was confirmed in experiments in which MG132 , an inhibitor of NF-kappaB activation , reversed the effect of AdAMP . Negative_regulation TNF RELA 12349954 992883 Catalposide , the major iridoid glycoside isolated from the stem bark of Catalpa ovata G. Don ( Bignoniaceae ) , was found to *inhibit* the productions of [tumor necrosis factor-alpha (TNF-alpha)] , interleukin-1beta (IL-1beta) , and interleukin-6 (IL-6) , and the activation of in RAW 264.7 macrophages activated with lipopolysaccharide (LPS) . Negative_regulation TNF RELA 12871593 1114133 *Activation* of as well as C/EBPbeta by p40 and inhibition of p40 induced expression of [TNF-alpha] by Deltap65 , a dominant negative mutant of p65 , and DeltaC/EBPbeta , a dominant negative mutant of C/EBPbeta , suggests that p40 induces the expression of TNF-alpha through the activation of NF-kappaB and C/EBPbeta . Negative_regulation TNF RELA 14503852 1144634 Astaxanthin also suppressed the serum levels of NO , PGE2 , [TNF-alpha] , and IL-1beta in LPS administrated mice , and *inhibited* activation as well as iNOS promoter activity in RAW264.7 cells stimulated with LPS . Negative_regulation TNF RELA 14575704 1156225 *dependent* regulation of [tumor necrosis factor-alpha] gene expression by CpG-oligodeoxynucleotides . Negative_regulation TNF RELA 14584760 1159102 Treatment of rats with HES ( 3.75 and 7.5 ml/kg ) prevented LPS induced activation , and *inhibited* , in a dose related manner , LPS induced [TNF-alpha] and CINC expression . Negative_regulation TNF RELA 14646597 1173169 is *involved* in the [TNF-alpha] induced inhibition of the differentiation of 3T3-L1 cells by reducing PPARgamma expression . Negative_regulation TNF RELA 14736953 1199592 We investigated the *role* of and AP-1 in [tumour necrosis factor alpha (TNF-alpha)] induced monocyte chemoattractant protein 1 ( MCP-1 ) production in cultured human glomerular endothelial cells ( HGEC ) . Negative_regulation TNF RELA 15322736 1287026 In vivo treatment with cloricromene ( 2 mg/kg/i.v. ) 30 min before lipopolysaccharide administration reversed the LPS induced loss in tone of the aortic rings , improved their reactivity to phenylephrine , decreased both nitric oxide ( NO ) and [TNF-alpha] serum levels by inhibiting LPS induced inducible NO synthase and TNF-alpha mRNA expression , and interestingly *inhibited* LPS induced activation . Negative_regulation TNF RELA 15659838 1350239 p7F also suppressed the serum level of [TNF-alpha] in mice treated with collagen and *inhibited* activation as well as NF-kappaB promoter activity in RAW 264.7 cells stimulated with LPS . Negative_regulation TNF RELA 15719215 1416774 The mechanisms involved in the anti-oxidative properties of 15d-PGJ2 in stress involve blockade ( by preventing stress induced IkappaBalpha decrease ) as well as *inhibition* of [TNFalpha] release in stressed animals . Negative_regulation TNF RELA 15723831 1396169 *dependent* down-regulation of [tumor necrosis factor] receptor associated proteins contributes to interleukin-1 mediated enhancement of ultraviolet B-induced apoptosis . Negative_regulation TNF RELA 15760549 1383240 Glycine could efficiently protect rat liver grafts from ischemia-reperfusion injury by repressing the expression of CD14 and binding activity in Kupffer cells and *inhibiting* the productions of [TNF alpha] and IL-1 . Negative_regulation TNF RELA 15901350 1409123 Taken together , the data demonstrate that MEMO has anti-inflammatory and antinociceptive activity , *inhibiting* iNOS , COX-2 and [TNF-alpha] expression by down regulating binding activity . Negative_regulation TNF RELA 15938622 1415417 Inhibition of by cobrotoxin *resulted* in reductions in the LPS induced expressions of COX-2 , iNOS , cPLA(2) , IL-4 , and [TNF-alpha] in astrocytes and in COX-2 expression induced by SNP , LPS , and TNF-alpha in astrocytes . Negative_regulation TNF RELA 15980040 1465295 Taken together , these data provide compelling evidence for the *role* of signaling in [TNF-alpha] gene expression in heart and highlight the importance of this proinflammatory gene-regulatory pathway as a potential therapeutic target in the management of cytokine induced myocardial dysfunction . Negative_regulation TNF RELA 16020286 1432109 Presence of the NF-kappaB inhibitor kamebakaurin in culture medium blocked P. aeruginosa induced activation and *inhibited* IL-6 , IL-8 , and [TNF-alpha] expression and secretion . Negative_regulation TNF RELA 16078585 1442531 The results indicated that thalidomide treatment significantly reduced colonic inflammation , suppressed activation , enhanced TNF-alpha mRNA degradation , *inhibited* the synthesis of the [TNF-alpha] , IEN-gamma and increased the production of IL-4 . Negative_regulation TNF RELA 16110831 1445340 DATS could downregulate [TNF-alpha] production and *inhibit* activation in lamina propria mononuclear cells of inflammed mucosa , without any effect on the viability of colonic tissue cells . Negative_regulation TNF RELA 16192349 1468323 repression of RelB activity *induces* selective gene activation downstream of [TNF] receptors . Negative_regulation TNF RELA 16288994 1484464 These results suggest that the inhibitory effect of equol on [TNF-alpha] expression is *mediated* , at least in part , by blocking activation and the inhibition of TNF-alpha expression by equol might be involved in its osteoprotective effect . Negative_regulation TNF RELA 16365438 1504945 Furthermore , we present evidence that A238L *inhibits* the activation of [TNF-alpha] by modulating , NF-AT , and c-Jun trans activation through a mechanism that involves CREB binding protein/p300 function , because overexpression of these transcriptional coactivators recovers TNF-alpha promoter activity . Negative_regulation TNF RELA 16455676 1534322 The aim of the present study is to examine whether this vitamin D inhibition of [TNFalpha] is *mediated* by its major transcription factor , . Negative_regulation TNF RELA 16526563 1536136 The production of [TNFalpha] was significantly *inhibited* by cationic decoy complex but not by cationic liposomes/random decoy complex or naked NFkappaB decoy . Negative_regulation TNF RELA 16770837 1682196 ADMA ( 30 microM ) significantly increased the activity of NF-kappaB and elevated the levels of ICAM-1 and [TNF-alpha] , and pre-treatment with rosiglitazone ( 10 or 30 microM ) markedly *inhibited* the increased activity of and reduced the elevated levels of TNF-alpha and ICAM-1 induced by ADMA in cultured endothelial cells . Negative_regulation TNF RELA 16774932 1672071 PMA selectively causes the degradation of IkappaB kinases ( IKKs ) including IKK-gamma and IKK-beta , and subsequent inhibition of [tumor necrosis factor (TNF)] *induced* IKK and activation in human colon cancer cell line HCT-116 , but not in other gastrointestinal tract cells . Negative_regulation TNF RELA 16965747 1616052 QGHXR can protect liver cells by down regulating the expressions of CD14 , TLR(4) and and *inhibiting* [TNF-alpha] expression . Negative_regulation TNF RELA 17115116 1709113 Resveratrol , a polyphenolic , natural phytoalexin found with particularly high levels in grape skin and red wine is potent and specific inhibitor of [TNF-alpha] and IL-1beta *induced* activation . Negative_regulation TNF RELA 17272828 1733239 The regulation was presumably at the transcriptional level , because mRNA expression for HSL and PLIN was markedly reduced with [TNF-alpha] in the *presence* of inhibition . Negative_regulation TNF RELA 17575011 1786115 FF demonstrated very potent glucocorticoid activity in several key pathways downstream of the glucocorticoid receptor (GR) as follows : the transrepression pathway , the transactivation glucocorticoid response element pathway , and *inhibition* of the proinflammatory cytokine [tumor necrosis factor-alpha] . Negative_regulation TNF RELA 17592223 1768205 Moderate , acute alcohol consumption or equivalent doses of alcohol in vitro had anti-inflammatory effects on monocyte activation via inhibition of pro-inflammatory genes and activation , *inhibition* of [TNFalpha] production and augmentation of the anti-inflammatory cytokine , IL-10 . Negative_regulation TNF RELA 17898021 1849056 Furthermore , the increased synthesis of IL-6 and [TNF-alpha] by anionic pIgA in HMC was significantly diminished ( P < 0.01 ) in the *presence* of NF-kappaB inhibitor pyrrolidine dithiocarbamate and blocking permeable peptides SN50 ( P < 0.01 ) . Negative_regulation TNF RELA 17931811 1819687 In lipopolysaccharide (LPS) stimulated RAW264.7 cells , HMCO5 inhibited activation as well as iNOS promoter activity , *inhibited* the secretion of [TNF-alpha] and IL-1beta , and directly inhibited the intracellular accumulation of reactive oxygen species . Negative_regulation TNF RELA 17953529 1814632 The mice with colitis treated by AN showed less tissue damage , less MPO activity , less [TNF-alpha] production in colon , and *inhibited* activation in LPMC , compared with those mice with colitis untreated , whereas the mice with colitis treated by CHD showed the worst tissue damage , the highest MPO activity , the highest TNF-alpha level , and enlarged NF-kappaB activation in LPMC . Negative_regulation TNF RELA 18385389 1925575 MT downregulated the [TNF-alpha] mRNA level , and PDTC *inhibited* the increases in both translocation and TNF-alpha mRNA . Negative_regulation TNF RELA 18559343 1952551 OxPAPC inhibited [tumor necrosis factor-alpha] production , IkappaBalpha degradation , p38 MAPK phosphorylation , and dependent reporter activation *induced* by stimulants of TLR2 and TLR4 ( Pam3CSK4 and LPS ) but not by stimulants of other TLRs ( poly ( I.C ) , flagellin , loxoribine , single stranded RNA , or CpG DNA ) in macrophages and HEK-293 cells transfected with respective TLRs and significantly reduced inflammatory responses in mice injected subcutaneously or intraperitoneally with Pam3CSK4 . Negative_regulation TNF RELA 18645721 1942285 Human lung epithelial cells ( A549 ) were stimulated with [tumor necrosis factor (TNF)-alpha] in the *presence* or absence of specific inhibitors of or the p38 MAP kinase and exposed to chlorobenzene using an air-liquid cell culture system . Negative_regulation TNF RELA 19023660 2035110 This study examines the *role* of in the regulation of [TNFalpha] production by morphine in microglia . Negative_regulation TNF RELA 19043204 1998813 Moreover , [TNF-alpha] production was *prevented* by and mitogen activated protein kinase (MAPK) inhibitors . Negative_regulation TNF RELA 19086324 2000268 The anti-inflammatory mechanisms of heparin in ALI may be *inhibiting* p38 MAPK and activities , and then [TNF-alpha] overexpression , thus alleviating the inflammatory reaction . Negative_regulation TNF RELA 19182383 2033247 Mangiferin also reduced acetylcholine and [tumor necrosis factor (TNF)-alpha] levels induced by scopolamine in mice brain ( p < 0.05 ) and *inhibited* activation in scopolamine or TNF-alpha stimulated BV-2 microglial cells . Negative_regulation TNF RELA 19220017 2179619 We describe herein the synthesis and biological activity of a series of imidazoline based scaffolds as potent inhibitors of *mediated* gene transcription in cell culture as well as inhibitors of [TNF-alpha] and IL-6 production in interleukin 1 beta (IL-1beta) stimulated human blood . Negative_regulation TNF RELA 19349680 2057595 Hemin further upregulated the expression of HO-1 mRNA , decreased activity drastically , and *inhibited* the serum levels of [TNF-alpha] and IL-6 significantly ( P < 0.05 ) . Negative_regulation TNF RELA 19616538 2124170 Ghrelin also significantly suppressed interleukin-1beta , [tumor necrosis factor-alpha] , and endothelin-l mRNA expression , and *inhibited* activation . Negative_regulation TNF RELA 19640904 2138164 PPAR-alpha reduced the *induced* overexpression of [TNF-alpha] and apoptosis in cultured kidney cells . Negative_regulation TNF RELA 19748795 2153102 ZD 7155 also reduced the mRNA expression of [TNF-alpha] and IL-1 beta , *inhibited* the activation of and AP-1 , and improved lung histopathology . Negative_regulation TNF RELA 20030669 2287268 In the ARDS model , vitamin K3 also suppressed the LPS induced increase in the serum [TNF-alpha] level and *inhibited* the LPS evoked nuclear translocation of in lung tissue . Negative_regulation TNF RELA 20231449 2230279 Silymarin suppressed [TNF-alpha] activation of NF-kappaB dependent transcription , which *involved* partial inhibition of IkappaB and serine phosphorylation , and p50 and p65 nuclear translocation , without affecting binding of p50 and p65 to DNA . Negative_regulation TNF RELA 20356387 2255197 Moreover , we explored the mechanism governing the expression of ATX in hepatoma cells and established a critical *role* of in basal and [TNF-alpha] induced ATX expression . Negative_regulation TNF RELA 20451670 2288422 Meanwhile , HES could significantly reduce [TNF-alpha] , IL-6 , and ICAM-1 mRNA , *inhibit* activation , and down-regulate TLR2 and TLR4 expression in the brain . Negative_regulation TNF RELA 20686703 2299245 Overexpression of itself , in turn , significantly *increased* [TNFalpha] promoter activity , an effect that was completely blocked by RelB overexpression . Negative_regulation TNF RELA 7608567 311955 Transcriptional *activation* of the human [TNF-alpha] promoter by superantigen in human monocytic cells : role of . Negative_regulation TNF RELA 7635431 317118 Using primary cultures of rat Kupffer cells the *role* of and activator protein 1 (AP-1) in the expression of the [tumor necrosis factor-alpha (TNF-alpha)] gene by lipopolysaccharide (LPS) was investigated . Negative_regulation TNF RELA 7913275 262070 HIV-1 expression was activated from J delta K cells by treatment with phorbol myristate acetate ( PMA ) , sodium butyrate ( NaB ) , or hexamethylene bisacetamide ( HMBA ) , but not tumor necrosis factor alpha (TNF-alpha) , confirming the *role* of in mediating [TNF-alpha] induction of HIV transcription . Negative_regulation TNF RELA 8598494 350741 We demonstrate that IL-1 and [TNF] *induce* rapid nuclear translocation of p65(RelA) in T cell clones , whereas TCR induced activation in Th1 cells is delayed and may be longer in duration . Negative_regulation TNF RELA 9003392 404833 Exposure of rat Kupffer cells to a physiologically relevant concentration of lipopolysaccharide ( 10 ng/ml ) activated NF-kappa B within 1 h and induced the release of TNF-alpha over 5 h. Cellular glutathione content remained unchanged after lipopolysaccharide exposure , but both glutathione monoethyl ester and N-acetyl-L-cysteine increased cellular glutathione levels , blocked activation and *inhibited* the release of [TNF-alpha] . Negative_regulation TNF RELA 9079634 420539 *Role* of in [tumor necrosis factor-alpha] and interleukin-1beta regulation . Negative_regulation TNF RELA 9415036 471902 Tosylphenylalanine chloromethyl ketone inhibits [TNF-alpha] mRNA synthesis in the *presence* of activated in RAW 264.7 macrophages . Negative_regulation TNF RELA 9415036 471904 Our results show that TPCK inhibits LPS induced [TNF-alpha] mRNA synthesis in the *presence* of activated and suggests that mechanisms other than NF-kappa B activation are involved in the transcriptional regulation of the TNF-alpha gene . Negative_regulation TNF RELA 9486215 488319 In the present study , electrophoretic mobility shift assays ( EM-SAs ) and pyrrolidine dithiocarbamate ( PDTC ) , an inhibitor of NF-kappa B activation , were utilized to determine the *role* of activation in TPA and [TNF-alpha] inhibition of the surfactant proteins in NCI-H441 cells . Negative_regulation TNF RELA 9486215 488331 The effects of PDTC and PTX on NF-kappa B and the surfactant proteins suggest that activation does not *mediate* TPA or [TNF-alpha] inhibition of SP-A and SP-B mRNA accumulation . Negative_regulation TNF RELA 9581775 503482 The protective *role* of in blocking [TNFalpha-] and HIV-1 induced apoptosis was supported by studies in Jurkat T cells engineered to express IkappaB alpha repressor mutants ( TD-IkappaB ) under the control of a tetracycline-responsive promoter . Negative_regulation TNF RELA 9802878 544025 In the present study , which uses mice with genetic deletions of the proteins of NF-kappaB complex , we provide data demonstrating that increased expression of the p50 subunit of directly *results* in the downregulation of LPS induced [TNF] production . Negative_regulation TNF RELB 16192349 1468324 RelA repression of activity *induces* selective gene activation downstream of [TNF] receptors . Negative_regulation TNF RELB 20686703 2299243 Moreover , overexpression in microglial cells *inhibited* Tat induced [TNFalpha] synthesis in a manner that involved transcriptional repression of the TNFalpha promoter , and increased phosphorylation of RelA at serine 276 , a prerequisite for increased RelB/RelA protein interactions . Negative_regulation TNF RFX1 23675837 2785387 Moreover , significantly *reduced* the production of IL-1 and [TNF-a] in the serum of AA ( p < 0.01 ) . Negative_regulation TNF RGL1 19627007 2112751 Ginsenoside *reduces* the expression of MCP-1 and [TNF-alpha] , repairs the pathological lesions of podocyte and nephron , and reduces the twenty-four hour urine protein rats with diabetic nephropathy . Negative_regulation TNF RGL2 19627007 2112754 Ginsenoside *reduces* the expression of MCP-1 and [TNF-alpha] , repairs the pathological lesions of podocyte and nephron , and reduces the twenty-four hour urine protein rats with diabetic nephropathy . Negative_regulation TNF RGL3 19627007 2112752 Ginsenoside *reduces* the expression of MCP-1 and [TNF-alpha] , repairs the pathological lesions of podocyte and nephron , and reduces the twenty-four hour urine protein rats with diabetic nephropathy . Negative_regulation TNF RGL4 19627007 2112753 Ginsenoside *reduces* the expression of MCP-1 and [TNF-alpha] , repairs the pathological lesions of podocyte and nephron , and reduces the twenty-four hour urine protein rats with diabetic nephropathy . Negative_regulation TNF RHOB 22869204 2775110 [TNF-a] and NO synthase are the target genes of nuclear factor-kappaB ( NF-?B ) , and overexpression of *increased* , whereas inhibition of RhoB decreased the basal and LPS activated transcriptional activity of NF-?B in the cells . Negative_regulation TNF RIPK1 19927158 2203737 To determine the *role* of in [TNF/IAP] antagonist induced death , we compared wild type ( WT ) and RIPK1 ( -/- ) mouse embryonic fibroblasts ( MEFs ) treated with these compounds . Negative_regulation TNF RIT2 19781666 2159214 and IRN concentration-dependently *attenuated* LPS induced production of proinflammatory cytokines such as [TNF-alpha] and IL-1beta as well as NO in mouse N9 microglial cells , with IRN showing more potent inhibition of microglial activation . Negative_regulation TNF RIT2 22322985 2681252 The results showed that markedly *reduced* the production of nitric oxide ( NO ) , prostaglandins E ( 2 ) ( PGE ( 2 ) ) , monocyte chemoattractant protein ( MCP-1 ) , [tumor necrosis factor-a (TNF-a)] and interleukin-1ß (IL-1ß) in LPS activated microglia . Negative_regulation TNF RLN1 19101597 2053719 In contrast , relaxin and modified *inhibited* endotoxin stimulated secretion of [TNF-alpha] and IL-6 by human macrophages , an effect sensitive to the glucocorticoid receptor antagonists RU-486 and D-06 . Negative_regulation TNF RLN2 19101597 2053720 In contrast , relaxin and modified *inhibited* endotoxin stimulated secretion of [TNF-alpha] and IL-6 by human macrophages , an effect sensitive to the glucocorticoid receptor antagonists RU-486 and D-06 . Negative_regulation TNF RLN3 19101597 2053721 In contrast , relaxin and modified *inhibited* endotoxin stimulated secretion of [TNF-alpha] and IL-6 by human macrophages , an effect sensitive to the glucocorticoid receptor antagonists RU-486 and D-06 . Negative_regulation TNF RNASE3 19384158 2069157 efficiently *impairs* the spontaneous maturation and secretion of proinflammatory [tumor necrosis factor-alpha] , interleukin-1beta , and interleukin-12 by slanDCs . Negative_regulation TNF RNASE3 20633653 2310399 Furthermore , *induced* high level of [TNF-alpha] secretion from RAW264.7 cells . Negative_regulation TNF RNF19A 9535085 497055 The ability of the yopJ mutant to downregulate and JNK and to *inhibit* production of [TNF-alpha] was restored by the expression of yopJ+ in trans . Negative_regulation TNF RPE 23133491 2696568 Meanwhile , *inhibited* KCs activation and subsequent hepatic [TNF-a] expression and downregulated the protein expression of endotoxin receptors , lipopolysaccharide binding protein (LBP) , CD14 , Toll-like receptor (TLR) 2 , and TLR4 in chronic alcohol intake rats . Negative_regulation TNF RPIA 8505858 221399 In the present study , we found that , 5'-N-ethylcarboxamido adenosine ( NECA ) , other agonists of adenosine receptors and dipyridamole , an adenosine uptake inhibitor , *inhibited* [tumor necrosis factor (TNF)] production by endotoxin stimulated human monocytes in a concentration dependent manner with no inhibition of interleukin-6 . Negative_regulation TNF RPS6KA5 17074860 1675556 The repression of expression with small interfering RNA *results* in reduced RelA phosphorylation and a significant decrease in the production of [TNF-alpha] in response to B. burgdorferi lysates . Negative_regulation TNF RPTOR 18523362 1840597 Either siRNA or siRNA Rictor *suppressed* [TNF-alpha] expression , but the latter suppressed the effects of GM3 on TNF-alpha expression and Akt phosphorylation at Ser ( 473 ) , indicating the GM3 signal to be transduced via Rictor/mTOR and Akt ( Ser ( 473 ) ) , leading to TNF-alpha stimulation . Negative_regulation TNF RPTOR 22351078 2561118 The aim of this study was to investigate the *role* of in myocardial [TNF-a] expression during endotoxemia . Negative_regulation TNF S100A12 10404006 629134 inhibits osteoclasts , stimulates insulin-like growth factor I and *inhibits* [tumor necrosis factor] alpha production by osteoblasts in vitro . Negative_regulation TNF S100A12 10843760 700330 Since high PCT levels have been described in human sepsis , and since *inhibits* [TNF] synthesis in rats , we examined the role of these peptides in the regulation of the inflammatory response during septic shock . Negative_regulation TNF S100A12 10843760 700331 In this model , PCT ( 10 ( -7 ) M ) and ( 10 ( -6 ) M ) significantly *inhibit* [TNF] production by 27 and 24 % respectively . Negative_regulation TNF S100A12 11012754 736126 Previously we showed that , a neuropeptide , *inhibited* lipopolysaccharide (LPS) induced [tumour necrosis factor-alpha (TNF-alpha)] production and increased interleukin (IL)-6 release at low concentrations via activation of the cAMP pathway in mouse peritoneal macrophages ( Mphi ) . Negative_regulation TNF S100A12 16317392 1487640 Finally , significantly *inhibits* LPS induced [TNF-alpha] released from mouse peritoneal macrophages . Negative_regulation TNF S100A12 17579082 1763911 In a murine model of endotoxemia , markedly *attenuated* serum [TNF-alpha] levels , and this effect was associated with the up-regulation of ICER . Negative_regulation TNF S100A12 19299480 2106070 In the present study , we demonstrate that is *involved* in morphine tolerance by differentially regulating the ERK dependent up-regulation of IL-1beta , [TNF-alpha] , and microsomal prostaglandin E synthase-1 ( mPGES-1 ) in astrocytes and p38 dependent up-regulation of IL-6 in microglia in the rat spinal cord . Negative_regulation TNF S100A12 9276092 450682 We recently reported that stimulates the production of the growth factor insulin-like growth factor-I and *inhibits* that of the cytokine [tumor necrosis factor-alpha] by osteoblasts , suggesting that CGRP may control bone cell activity . Negative_regulation TNF S100A12 9417811 472231 We show that *inhibits* the production of [TNF-alpha] by both lipopolysaccharide (LPS)- and IL-1 stimulated fetal rat osteoblasts . Negative_regulation TNF SBF1 15763366 1383383 Furthermore , ( 0.05-0.25 mg/ml ) dose-dependently *suppressed* LPS induced [TNF-alpha] , IL-1beta , IL-6 , NO and PGE2 in activated RAW264.7 cells without exerting cytotoxicity . Negative_regulation TNF SBF2 15763366 1383384 Furthermore , ( 0.05-0.25 mg/ml ) dose-dependently *suppressed* LPS induced [TNF-alpha] , IL-1beta , IL-6 , NO and PGE2 in activated RAW264.7 cells without exerting cytotoxicity . Negative_regulation TNF SCARB1 19576750 2286953 However , inhibition of expression by siRNA *increased* iNOS expression and p38 phosphorylation in [TNF-alpha-] and IFN-gamma stimulated C6 cells . Negative_regulation TNF SCG2 7542064 310912 However , , NED , and IFN inhibit TNF-alpha dependent cytotoxicity by both PMCs and IMMCs and *reduce* the steady-state levels of mRNA for [TNF-alpha] in PMCs . Negative_regulation TNF SCG3 7542064 310914 However , , NED , and IFN inhibit TNF-alpha dependent cytotoxicity by both PMCs and IMMCs and *reduce* the steady-state levels of mRNA for [TNF-alpha] in PMCs . Negative_regulation TNF SCG5 7542064 310913 However , , NED , and IFN inhibit TNF-alpha dependent cytotoxicity by both PMCs and IMMCs and *reduce* the steady-state levels of mRNA for [TNF-alpha] in PMCs . Negative_regulation TNF SEA 19812189 2154324 *suppressed* the LPS induced DCs production of IL-1beta , IL-6 , IL-12 , and [TNF-alpha] and enhanced TGF-beta as well as IL-10 production . Negative_regulation TNF SELE 11888521 920048 Inhibition of [TNF-alpha] *induced* ICAM-1 , VCAM-1 and expression by selenium . Negative_regulation TNF SELL 8609224 352765 In the absence of serum , galactoxylomannan and mannoprotein did not affect L-selectin , [TNF] receptor , CD15 , CD11b , or CD16 on neutrophils but did *induce* loss of in the presence of serum . Negative_regulation TNF SERPINA1 17395890 1766209 Hirudin , a thrombin inhibitor , and aprotinin , an inhibitor of plasmin , reduced smoke mediated [TNF-alpha] and MMP-12 release , and *inhibited* both plasmin and thrombin activity in a cell-free functional assay . Negative_regulation TNF SERPINA1 23526215 2803987 Despite an initial marked augmentation of TNF-a self induced transcription , *inhibited* [TNF-a] receptor 1 up-regulation and significantly reduced TNF-a secretion , effects that were associated with inhibition of TNF-a converting enzyme activity . Negative_regulation TNF SERPINA1 2472279 113666 The secretion of [tumor necrosis factor (TNF)] by human peripheral blood mononuclear cells was *suppressed* by either whole human plasma alpha-globulins or purified alpha 1-acid-glycoprotein , and alpha 2-macroglobulin in a concentration dependent manner . Negative_regulation TNF SERPINA12 19801900 2148199 did not *inhibit* the [TNF-alpha] ( 20 min ) activation of JNK , p38 and NF-kappaB , but only slightly inhibited Akt . Negative_regulation TNF SERPINA12 24418398 2926968 Results showed that *inhibited* [TNF-a] and IL-1 mediated activation of NF-?B and its downstream molecules in a concentration dependent manner ( P < 0.05 ) . Negative_regulation TNF SERPINA4 20377366 2181282 gene transfer *reduced* the levels of interleukin-1beta and [tumor necrosis factor-alpha] in joints . Negative_regulation TNF SERPINB2 9607921 508685 These observations , together with the recently demonstrated *mediated* inhibition of [tumor necrosis factor-alpha] induced apoptosis , ( a ) illustrate that PAI-2 has an additional and distinct function as an intracellular regulator of signal transduction pathway ( s ) and ( b ) demonstrate a novel activity for a eukaryotic serpin . Negative_regulation TNF SERPINB9 15128837 1245287 IFN-gamma and [TNF-alpha] also *induced* 4- to 10-fold higher levels of mRNA expression in Huh-7 cells , whereas levels of mRNA encoding a related serine proteinase inhibitor , proteinase inhibitor 8 , were unaffected by culture of Huh-7 cells with IFN-alpha , IFN-gamma , or TNF-alpha . Negative_regulation TNF SERPINC1 12010802 941299 In parallel to reducing NF-kappaB activity , *inhibited* the expression of interleukin-6 , [tumor necrosis factor-alpha] , and tissue factor , genes known to be under the control of NF-kappaB . Negative_regulation TNF SERPINC1 21962807 2507336 and 6 h , the increased [TNF-a] and IL-1ß levels in plasma and MPO activity in lung tissue by LPS could be significantly *inhibited* by fasudil . Negative_regulation TNF SERPINE1 15543343 1337717 Fasting serum lipids , homocysteine , total and free tissue factor pathway inhibitor (TFPI) , plasminogen activator *inhibitor* ( ) and tissue plasminogen activator (t-PA) antigen and activity , C-reactive protein (CRP) , interleukin-6 (IL-6) and [tumor necrosis factor-alpha (TNF-alpha)] were measured . Negative_regulation TNF SERPINE1 18295937 1951159 Levels of interleukin-6 (IL-6) , [tumor necrosis factor alpha (TNF-alpha)] , C-reactive protein (CRP) , fibrinogen (Fib) , plasminogen activator *inhibitor* ( ) , von Willebrand factor (vWF) and tissue plasminogen activator (tPA) were determined at baseline and 4 h after alcohol consumption . Negative_regulation TNF SERPINE1 20739390 2341668 FM-MSC transplantation significantly reduced activated mesangial cell ( MC ) proliferation , glomerular monocyte/macrophage infiltration , mesangial matrix accumulation , as well as the glomerular expression of inflammatory or extracellular matrix related genes including [TNF-a] , monocyte chemoattractant protein 1 ( MCP-1 ) , type I collagen , TGF-ß , type 1 plasminogen activator *inhibitor* ( ) ( P < 0.05 vs. PBS group ) . Negative_regulation TNF SERPINE1 8604004 352325 Anti-uPA monoclonal antibody ( mAb ) suppressed LPS-driven [TNF-alpha] secretion by 61.6 +/- 5.9 % ( P < .001 ) , and , a uPA inhibitor , *suppressed* it to 53.1 +/- 8.2 % of the control value ( P < .001 ) . Negative_regulation TNF SERPINE2 17073633 1637787 In the present review we attempt to summarize the majority of these , including the genes of matrix metalloproteinases and their *inhibitors* , elastin , , [tumor necrosis factor] - a , transforming growth factor beta , a variety of interleukins and their receptors and antagonists , high affinity IgE receptor , human calcium activated chloride channel 1 , heme oxygenase , vascular endothelial growth factor , microsomal epoxide hydrolase , glutathione S-transferase , cytochrome P45O , superoxide dismutase , vitamin D binding protein , beta2-adrenergic receptor , Toll like receptor , human B defensins , mucins , cystic fibrosis transmembrane regulator , surfactant protein and Nuclear Factor E2 Related Factor 2 . Negative_regulation TNF SERPING1 12928411 1132014 Both forms of blocked the LPS binding protein dependent binding of Salmonella typhimurium LPS to the murine macrophage cell line , RAW 264.7 , and *suppressed* LPS induced [TNF-alpha] mRNA expression . Negative_regulation TNF SETBP1 10569782 568069 In contrast , induced protein kinase C ( PKC ) translocation , and pretreatment of cultures with inhibitors of PKC *blocked* [TNF-alpha] induction . Negative_regulation TNF SETBP1 20041187 2177289 The binding of to Vbeta chain *results* in rapid activation of T cells and production of inflammatory cytokines , such as Interleukin-2 (IL-2) , Interferon-gamma and [Tumor Necrosis Factor-alpha] which mediate TSS . Negative_regulation TNF SETBP1 9864222 582819 In vitro stimulation of lymphocytes isolated from soluble beta-glucan treated mice with lipopolysaccharide (LPS) resulted in enhanced production of interleukin-6 (IL-6) and suppressed production of tumor necrosis factor alpha (TNF-alpha) , while stimulation of these cells with or toxic shock syndrome toxin 1 ( TSST-1 ) resulted in enhanced production of gamma interferon ( IFN-gamma ) and *suppressed* production of IL-2 and [TNF-alpha] compared to that in cells isolated from untreated mice . Negative_regulation TNF SETBP1 9864222 582821 In vitro stimulation of monocytes isolated from soluble beta-glucan treated mice with LPS also resulted in suppressed TNF-alpha production , while stimulation of these cells with or TSST-1 *resulted* in suppressed IL-6 and [TNF-alpha] production compared to that in cells isolated from untreated mice . Negative_regulation TNF SETD2 23085511 2698945 In this study , we investigated direct effects of hypoxia on TNF-a expression of cardiomyocytes , the *role* of in [TNF-a] regulation and potential secretory pathway of TNF-a . Negative_regulation TNF SFN 20039434 2192725 was found to *inhibit* synovial hyperplasia , activated T cell proliferation , and the production of IL-17 and [TNFalpha] by rheumatoid T cells in vitro . Negative_regulation TNF SFPQ 18379056 1888650 could also markedly *inhibit* production of proinflammatory cytokines , especially IL-1 beta , IL-6 and [TNF-alpha] , but enhance production of anti-inflammatory cytokines of IL-4 and IL-10 in the carrageenan injected paw tissues in rats . Negative_regulation TNF SFTPA1 11724772 914828 *inhibits* peptidoglycan induced [tumor necrosis factor-alpha] secretion in U937 cells and alveolar macrophages by direct interaction with toll-like receptor 2 . Negative_regulation TNF SFTPA1 9804173 544160 Induction of [TNF-alpha] release from human buffy coat cells by Pseudomonas aeruginosa is *reduced* by lung . Negative_regulation TNF SFTPA2 10580796 570119 Moreover , and P101 also *inhibit* the release of histamine and [TNF-alpha] induced by dSP suggesting that a receptor independent mechanism is involved . Negative_regulation TNF SFTPA2 11724772 914829 *inhibits* peptidoglycan induced [tumor necrosis factor-alpha] secretion in U937 cells and alveolar macrophages by direct interaction with toll-like receptor 2 . Negative_regulation TNF SFTPA2 23475791 2865519 We also observed that the peptide *inhibits* LPS induced expression of [TNF-a] , nuclear localization of NF-?B-p65 and cell influx , and alleviates the endotoxic shock-like symptoms in a mouse model . Negative_regulation TNF SFTPA2 9804173 544161 Induction of [TNF-alpha] release from human buffy coat cells by Pseudomonas aeruginosa is *reduced* by lung . Negative_regulation TNF SFTPD 18554706 1959085 *inhibits* [TNF-alpha] production by macrophages and dendritic cells in mice . Negative_regulation TNF SFXN1 23261487 2741344 In a mouse model of LPS induced septic shock , *inhibited* the production of [tumor necrosis factor (TNF)-a] , interleukin (IL)-1ß , and IL-6 , and increased survival by 83 % . Negative_regulation TNF SIGIRR 20112371 2219500 In vivo , lack of *increased* surface CD40 expression on spleen CD11c ( + ) dendritic cells and MX-1 , [TNF] , IL-12 , BAFF and BCL-2 mRNA expression 6 months after pristane injection . Negative_regulation TNF SIGLEC7 8679222 372503 Interestingly , activation of the TNF alpha-p75 receptor with a selective agonist , recombinant TNF ( rTNF alpha-p75 ) , or *inhibition* of the [TNF alpha-p75] receptor with utr-1 , an inhibitory anti-TNF alpha-p75 receptor antibody , had no effect on TNF alpha augmented calcium transients or on myocyte growth . Negative_regulation TNF SIGLEC9 18325328 1886208 A membrane proximal ITIM mutant of did not enhance IL-10 production but partly *inhibited* [TNF-alpha] production , indicating diverse regulation mechanisms of TNF-alpha and IL-10 . Negative_regulation TNF SIRPA 12115605 964202 We observed that the production of [TNFalpha] , a cytokine that we have earlier identified as important in the mechanism of MyD-1 immune regulation , is *inhibited* by cross linking of . Negative_regulation TNF SIRPA 12805067 1140916 Specifically , we demonstrate that ligation of on peripheral blood mononuclear cells ( PBMCs ) *inhibits* [tumor necrosis factor alpha (TNFalpha)] secretion but has no effect on other cytokines induced in response to each of these products . Negative_regulation TNF SIRPB1 19893026 2171455 Activation of on cultured microglia by cross linking antibodies induced reorganization of the cytoskeleton protein beta-actin and *suppressed* lipopolysaccharide induced gene transcription of [tumor necrosis factor-alpha] and nitric oxide synthase-2 . Negative_regulation TNF SIRT1 19299582 2064127 Role of in regulation of LPS- or two ethanol metabolites *induced* [TNF-alpha] production in cultured macrophage cell lines . Negative_regulation TNF SIRT1 19299582 2064128 In the present study , we examined the *role* of signaling in [TNF-alpha] generation stimulated by either lipopolysaccharide (LPS) , acetaldehyde (AcH) , or acetate ( two major metabolites of ethanol ) in two cultured macrophage cell lines . Negative_regulation TNF SIRT1 19996381 2210443 We also demonstrate that activators *inhibit* LPS stimulated inflammatory pathways , as well as secretion of [TNFalpha] , in a SIRT1 dependent manner in RAW264.7 cells and in primary intraperitoneal macrophages . Negative_regulation TNF SIRT1 23075766 2710538 The present study provides the direct evidence that can *inhibit* [TNF-a-] induced CD40 expression in CRL-1730 endothelial cells by deacetylating the RelA/p65 subunit of NF-?B at lysine 310 , which provides new insights into understanding of the anti-inflammatory and anti-athroscerotic actions of SIRT1 . Negative_regulation TNF SIRT1 24039666 2842332 [TNF] production by PBMC was significantly *down-regulated* by in HC and AS patients . Negative_regulation TNF SIRT1 24702436 2942961 We found that overexpression *prevented* [TNF-a-] and high-glucose dependent nuclear factor-?B ( NF-?B ) -p65 acetylation , E-selectin promoter activity , E-selectin release and adhesion of THP-1 cells to HUVECs . Negative_regulation TNF SIRT2 24039666 2842331 [TNF] production by PBMC was significantly *down-regulated* by in HC and AS patients . Negative_regulation TNF SIRT3 24039666 2842333 [TNF] production by PBMC was significantly *down-regulated* by in HC and AS patients . Negative_regulation TNF SIRT4 24039666 2842334 [TNF] production by PBMC was significantly *down-regulated* by in HC and AS patients . Negative_regulation TNF SIRT5 24039666 2842335 [TNF] production by PBMC was significantly *down-regulated* by in HC and AS patients . Negative_regulation TNF SIRT6 23086953 2703572 increases the nuclear levels of the Ca ( 2+ ) -dependent transcription factor , nuclear factor of activated T cells ( NFAT ) , and cyclosporin A , a calcineurin inhibitor that reduces NFAT activity , *reduces* [TNF] and IL8 expression in SIRT6 overexpressing cells . Negative_regulation TNF SIRT6 24039666 2842336 [TNF] production by PBMC was significantly *down-regulated* by in HC and AS patients . Negative_regulation TNF SIRT7 24039666 2842337 [TNF] production by PBMC was significantly *down-regulated* by in HC and AS patients . Negative_regulation TNF SKIV2L 16141526 1451023 *inhibited* significantly [TNF-alpha] release ( IC50 = 97.6+/-17.8 microg/ml ) and NO production ( IC50 = 280+/-17.8 microg/ml ) . Negative_regulation TNF SLC25A3 12022753 943290 Although PTK was the predominant signaling pathway , inhibition of only partially *restored* the [TNF-alpha] response to SAC-I . Negative_regulation TNF SLC4A1 15318098 1286377 An EP4 agonist *suppresses* excess [TNF-alpha] secretion from macrophages and seems promising for future trial in patients with severe alcoholic hepatitis . Negative_regulation TNF SLC4A1 16357326 1539701 AE-248 , , and AE-329 all *inhibited* Fc epsilonRI mediated [TNF-alpha] generation , while AE1-259-01 blocked eicosanoid production . Negative_regulation TNF SLC9A1 19384202 2074951 inhibition also *resulted* in reduced plasma levels of [tumor necrosis factor-alpha] , intercellular adhesion molecule-1 , and C-reactive protein , and attenuated neutrophil infiltration in the liver . Negative_regulation TNF SLPI 12668158 1075715 Neither intact nor half sized SLPI ( 1/2 SLPI ) *down-regulated* Mphi [TNF-alpha] production . Negative_regulation TNF SLPI 12874244 1114995 Exposure of RAW264.7 cells to apoptotic CTLL-2 cells induced both SLPI and [TNF-alpha] , and addition of IFN-gamma *inhibited* but augmented TNF-alpha production . Negative_regulation TNF SLPI 16112212 1454290 Expression of the protease inhibition mutants *suppressed* NO and [TNF] production in response to LPS in a similar fashion as wild type SLPI . Negative_regulation TNF SLURP1 19396877 2106479 Collectively , these results suggest that *contributes* to the maintenance of bronchial epithelial cell homeostasis and to the regulation of [TNF-alpha] release from macrophages in bronchial tissue . Negative_regulation TNF SMAD1 16214042 1501096 Overexpression of USP31 in HEK 293T cells inhibited [TNFalpha] , CD40 , LMP1 , TRAF2 , TRAF6 and IKKbeta mediated NF-kappaB activation , but did not *inhibit* mediated transcription activation . Negative_regulation TNF SMAD2 16214042 1501097 Overexpression of USP31 in HEK 293T cells inhibited [TNFalpha] , CD40 , LMP1 , TRAF2 , TRAF6 and IKKbeta mediated NF-kappaB activation , but did not *inhibit* mediated transcription activation . Negative_regulation TNF SMAD3 16214042 1501098 Overexpression of USP31 in HEK 293T cells inhibited [TNFalpha] , CD40 , LMP1 , TRAF2 , TRAF6 and IKKbeta mediated NF-kappaB activation , but did not *inhibit* mediated transcription activation . Negative_regulation TNF SMAD4 16214042 1501099 Overexpression of USP31 in HEK 293T cells inhibited [TNFalpha] , CD40 , LMP1 , TRAF2 , TRAF6 and IKKbeta mediated NF-kappaB activation , but did not *inhibit* mediated transcription activation . Negative_regulation TNF SMAD5 16214042 1501100 Overexpression of USP31 in HEK 293T cells inhibited [TNFalpha] , CD40 , LMP1 , TRAF2 , TRAF6 and IKKbeta mediated NF-kappaB activation , but did not *inhibit* mediated transcription activation . Negative_regulation TNF SMAD6 16214042 1501101 Overexpression of USP31 in HEK 293T cells inhibited [TNFalpha] , CD40 , LMP1 , TRAF2 , TRAF6 and IKKbeta mediated NF-kappaB activation , but did not *inhibit* mediated transcription activation . Negative_regulation TNF SMAD7 11314022 806352 In addition , *inhibited* [TNF-alpha] stimulation of NF-kappaB and increased TNF-alpha mediated apoptosis in MDCK cells . Negative_regulation TNF SMAD7 15752249 1379938 Real-time polymerase chain reaction ( PCR ) and immunohistochemistry revealed that gene transfer of *resulted* in a substantial inhibition of interleukin-1beta (IL-1beta) and [tumor necrosis factor alpha (TNFalpha)] expression ( all P < 0.01 vs. control ) . Negative_regulation TNF SMAD7 16214042 1501102 Overexpression of USP31 in HEK 293T cells inhibited [TNFalpha] , CD40 , LMP1 , TRAF2 , TRAF6 and IKKbeta mediated NF-kappaB activation , but did not *inhibit* mediated transcription activation . Negative_regulation TNF SMAD7 17384642 1727706 The formation of Smad7-TAB2 and complexes *resulted* in the suppression of [TNF] signaling through the adaptors TRAF2 , TAB2 and/or TAB3 , and TAK1 . Negative_regulation TNF SMAD9 16214042 1501103 Overexpression of USP31 in HEK 293T cells inhibited [TNFalpha] , CD40 , LMP1 , TRAF2 , TRAF6 and IKKbeta mediated NF-kappaB activation , but did not *inhibit* mediated transcription activation . Negative_regulation TNF SMARCA4 19556365 2117145 Here , we examined the *role* of , a chromatin remodeling enzyme , in the transcription of [TNF-alpha] and MCP-1 in response to renal ischemia . Negative_regulation TNF SMPD1 20236926 2272971 Studies on the *role* of and ceramide in the regulation of tumor necrosis factor alpha (TNFalpha) converting enzyme activity and [TNFalpha] secretion in macrophages . Negative_regulation TNF SMPD2 17085432 1675738 *Role* for in [tumor necrosis factor] alpha stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells : p38 MAPK is an upstream regulator of nSMase2 . Negative_regulation TNF SNORA73A 10949027 723248 Thus , 19K *blocks* [TNF-alpha] mediated death signaling by inhibiting a specific form of Bax that interrupts caspase activation downstream of caspase-8 and upstream of caspase-9 . Negative_regulation TNF SNORA73A 8869358 389304 Adenovirus 19 kDa *blocks* the proapoptotic activity of [TNF alpha] . Negative_regulation TNF SNRPF 23799821 2854190 Moreover , suppressed synovial inflammation and *inhibited* release of interleukin-1ß (IL-1ß) and [tumor necrosis factor-a] in serum . Negative_regulation TNF SOCS1 12032139 968173 A further analysis revealed that deficiency *results* in augmented [TNF] signaling via the p38 mitogen activated protein kinase pathway but not NFkappaB or c-Jun N-terminal kinase pathways . Negative_regulation TNF SOCS1 12193701 981424 Additionally , IFN-gamma induced [TNF-alpha] secretion , as well as STAT-1alpha and NF-kappaB activation , are inhibited in the *presence* of . Negative_regulation TNF SOCS1 15100317 1239744 Additionally , IFN-gamma induced class I MHC up-regulation and [TNF-] and IFN-gamma induced IL-15 expression by beta cells were *inhibited* by , which correlated with suppressed 8.3 T cell proliferation in vitro . Negative_regulation TNF SOCS1 15173123 1259156 We also show that the activations of Jaks and caspases by [TNF-alpha] are *suppressed* by . Negative_regulation TNF SOCS1 19763396 2158872 We demonstrate that does not *prevent* increase in NO production and decrease in glucose stimulated insulin secretion in the presence of IL-1beta , IFNgamma , [TNFalpha] . Negative_regulation TNF SOCS1 20406299 2300597 These data suggest that is not *involved* in the suppression of LPS induced [TNF-alpha] production by IL-4 . Negative_regulation TNF SOCS3 12055259 951833 Constitutive expression also down-regulated the mRNA expression of inducible NO synthase and IL-6 and *impaired* the production of [TNF-alpha] , mainly at a post-transcriptional level . Negative_regulation TNF SOCS3 14688368 1190742 Overexpression of STAT3 DN completely inhibited IL-10 induced , tissue *inhibitor* of MMP-1 , [TNF] receptor expression , and the recently identified IL-10-inducible genes , T cell protein tyrosine phosphatase and signaling lymphocyte activation molecule . Negative_regulation TNF SOCS3 16505233 1529387 Moreover , is *required* for [tumor necrosis factor-alpha] full inhibition of insulin stimulated IRS-1 and -2 phosphorylation , phosphatidylinositol 3 kinase activity , and glucose uptake . Negative_regulation TNF SOCS3 17297444 1765612 In vitro , overexpression *reduced* proliferation , IL-6 mediated STAT3 activation and [tumor necrosis factor (TNF)] alpha mediated NF-kappaB activation . Negative_regulation TNF SOCS3 23129128 2751165 Kallikrein binding protein *inhibits* LPS induced [TNF-a] by upregulating expression . Negative_regulation TNF SOCS3 24659790 2949105 Furthermore , we found that SOCS3 associates with TRAF2 and inhibits TRAF2 mediated NF-?B promoter activity , suggesting a mechanism by which *inhibits* [TNF-a] mediated signaling . Negative_regulation TNF SOD1 11589516 867864 Liposome encapsulated *suppresses* liposome mediated augmentation of [TNF-alpha] production from peripheral blood leucocytes . Negative_regulation TNF SOD1 16822952 1625237 The [TNF-alpha] response was *inhibited* by and catalase suggesting apoptosis is oxidative stress related . Negative_regulation TNF SOD1 20824052 2318550 Short interfering RNA ( siRNA ) -mediated knockdown of one of the photoaffinity labeled proteins , , an ROS scavenger , *resulted* in an increase in [tumor necrosis factor-alpha] production by RAW 264.7 cells in response to DMXAA compared with negative or positive controls transfected with nontargeting or lamin A/C targeting siRNA molecules , respectively . Negative_regulation TNF SOD1 22189681 2518539 Histological , Western blot , and reverse transcription-polymerase chain reaction data demonstrated that silk fibroin peptide or alone could *suppress* elevated levels of cyclooxygenase-2 , interleukin-6 , interleukin-1beta , and [tumor necrosis factor-alpha] induced by TPA . Negative_regulation TNF SOD1 9214459 441606 After 24 hours of preservation , superoxide generation was inhibited in the control livers by anti-TNF antiserum , whereas [TNF] release was not *inhibited* by . Negative_regulation TNF SOD2 11589516 867865 Liposome encapsulated *suppresses* liposome mediated augmentation of [TNF-alpha] production from peripheral blood leucocytes . Negative_regulation TNF SOD2 16822952 1625238 The [TNF-alpha] response was *inhibited* by and catalase suggesting apoptosis is oxidative stress related . Negative_regulation TNF SOD2 22189681 2518540 Histological , Western blot , and reverse transcription-polymerase chain reaction data demonstrated that silk fibroin peptide or alone could *suppress* elevated levels of cyclooxygenase-2 , interleukin-6 , interleukin-1beta , and [tumor necrosis factor-alpha] induced by TPA . Negative_regulation TNF SOD2 9214459 441607 After 24 hours of preservation , superoxide generation was inhibited in the control livers by anti-TNF antiserum , whereas [TNF] release was not *inhibited* by . Negative_regulation TNF SOD3 11589516 867866 Liposome encapsulated *suppresses* liposome mediated augmentation of [TNF-alpha] production from peripheral blood leucocytes . Negative_regulation TNF SOD3 16822952 1625239 The [TNF-alpha] response was *inhibited* by and catalase suggesting apoptosis is oxidative stress related . Negative_regulation TNF SOD3 19495415 2091806 overexpression significantly *reduced* [TNFalpha] , IL1alpha , IL6 , MIP2 , and MCP-1 cytokine and VCAM , ICAM , P-selectin , and E-selectin adhesion molecule expressions in injured tissues . Negative_regulation TNF SOD3 22189681 2518541 Histological , Western blot , and reverse transcription-polymerase chain reaction data demonstrated that silk fibroin peptide or alone could *suppress* elevated levels of cyclooxygenase-2 , interleukin-6 , interleukin-1beta , and [tumor necrosis factor-alpha] induced by TPA . Negative_regulation TNF SOD3 9214459 441608 After 24 hours of preservation , superoxide generation was inhibited in the control livers by anti-TNF antiserum , whereas [TNF] release was not *inhibited* by . Negative_regulation TNF SOST 22923429 2837605 Studies assessing mechanisms of estrogen action on bone in humans have identified effects of estrogen on RANKL expression by several different cell types in the bone microenvironment , a *role* for [TNF-a] and IL-1ß in mediating effects of estrogen deficiency on bone , and possible regulation of the Wnt inhibitor , , by estrogen . Negative_regulation TNF SP100 12773323 1113387 Under similar conditions of presentation , inhibits the mitogenic effect of lipopolysaccharide on mouse splenocytes , and *inhibits* the lipopolysaccharide induced production of [tumor necrosis factor-alpha] by peritoneal and alveolar macrophages , and of nitric oxide by RAW 264.7 cells . Negative_regulation TNF SPAG11B 21075851 2376662 Interestingly , we found that activation of and EP4 receptors , but not EP1 , EP3 , PGI(2) receptor ( IP ) , thromboxane A(2) receptor ( TP ) , PGD(2) receptor ( DP ) , and PGF ( 2 ) receptor ( FP ) , efficiently *blocked* LPS induced [tumor necrosis factor a (TNFa)] synthesis and COX-2 and mPGES-1 induction as well as prostaglandin synthesis in spinal cultures . Negative_regulation TNF SPG11 15312003 1285122 We found that dramatically *inhibited* LPS induced increases of [tumor necrosis factor-alpha (TNF-alpha)] in the plasma and bile in vivo . Negative_regulation TNF SPG14 15312003 1285125 We found that dramatically *inhibited* LPS induced increases of [tumor necrosis factor-alpha (TNF-alpha)] in the plasma and bile in vivo . Negative_regulation TNF SPG16 15312003 1285126 We found that dramatically *inhibited* LPS induced increases of [tumor necrosis factor-alpha (TNF-alpha)] in the plasma and bile in vivo . Negative_regulation TNF SPG18 15312003 1285128 We found that dramatically *inhibited* LPS induced increases of [tumor necrosis factor-alpha (TNF-alpha)] in the plasma and bile in vivo . Negative_regulation TNF SPG19 15312003 1285127 We found that dramatically *inhibited* LPS induced increases of [tumor necrosis factor-alpha (TNF-alpha)] in the plasma and bile in vivo . Negative_regulation TNF SPG20 15312003 1285129 We found that dramatically *inhibited* LPS induced increases of [tumor necrosis factor-alpha (TNF-alpha)] in the plasma and bile in vivo . Negative_regulation TNF SPG21 15312003 1285130 We found that dramatically *inhibited* LPS induced increases of [tumor necrosis factor-alpha (TNF-alpha)] in the plasma and bile in vivo . Negative_regulation TNF SPG23 15312003 1285131 We found that dramatically *inhibited* LPS induced increases of [tumor necrosis factor-alpha (TNF-alpha)] in the plasma and bile in vivo . Negative_regulation TNF SPG24 15312003 1285132 We found that dramatically *inhibited* LPS induced increases of [tumor necrosis factor-alpha (TNF-alpha)] in the plasma and bile in vivo . Negative_regulation TNF SPG25 15312003 1285133 We found that dramatically *inhibited* LPS induced increases of [tumor necrosis factor-alpha (TNF-alpha)] in the plasma and bile in vivo . Negative_regulation TNF SPG27 15312003 1285134 We found that dramatically *inhibited* LPS induced increases of [tumor necrosis factor-alpha (TNF-alpha)] in the plasma and bile in vivo . Negative_regulation TNF SPG29 15312003 1285135 We found that dramatically *inhibited* LPS induced increases of [tumor necrosis factor-alpha (TNF-alpha)] in the plasma and bile in vivo . Negative_regulation TNF SPG32 15312003 1285136 We found that dramatically *inhibited* LPS induced increases of [tumor necrosis factor-alpha (TNF-alpha)] in the plasma and bile in vivo . Negative_regulation TNF SPG34 15312003 1285137 We found that dramatically *inhibited* LPS induced increases of [tumor necrosis factor-alpha (TNF-alpha)] in the plasma and bile in vivo . Negative_regulation TNF SPG36 15312003 1285138 We found that dramatically *inhibited* LPS induced increases of [tumor necrosis factor-alpha (TNF-alpha)] in the plasma and bile in vivo . Negative_regulation TNF SPG37 15312003 1285139 We found that dramatically *inhibited* LPS induced increases of [tumor necrosis factor-alpha (TNF-alpha)] in the plasma and bile in vivo . Negative_regulation TNF SPG38 15312003 1285140 We found that dramatically *inhibited* LPS induced increases of [tumor necrosis factor-alpha (TNF-alpha)] in the plasma and bile in vivo . Negative_regulation TNF SPG41 15312003 1285141 We found that dramatically *inhibited* LPS induced increases of [tumor necrosis factor-alpha (TNF-alpha)] in the plasma and bile in vivo . Negative_regulation TNF SPG45 15312003 1285142 We found that dramatically *inhibited* LPS induced increases of [tumor necrosis factor-alpha (TNF-alpha)] in the plasma and bile in vivo . Negative_regulation TNF SPG56 15312003 1285143 We found that dramatically *inhibited* LPS induced increases of [tumor necrosis factor-alpha (TNF-alpha)] in the plasma and bile in vivo . Negative_regulation TNF SPG7 15312003 1285123 We found that dramatically *inhibited* LPS induced increases of [tumor necrosis factor-alpha (TNF-alpha)] in the plasma and bile in vivo . Negative_regulation TNF SPG9 15312003 1285124 We found that dramatically *inhibited* LPS induced increases of [tumor necrosis factor-alpha (TNF-alpha)] in the plasma and bile in vivo . Negative_regulation TNF SPHK1 10944534 744116 Activation of endogenous SK activity by [tumor necrosis factor-alpha (TNFalpha)] , interleukin-1beta , and phorbol esters in HEK293T cells was *blocked* by expression of this inactive ( hSK ( G82D ) ) . Negative_regulation TNF SPHK1 15710602 1395746 [Tumor necrosis factor] *induces* the loss of by a cathepsin B-dependent mechanism . Negative_regulation TNF SPHK1 16272312 1479403 Consistently , overexpression of dominant negative *increased* the production of IL-2 , [TNF-alpha] , and IFN-gamma in Th1 cells . Negative_regulation TNF SPHK1 17114809 1677166 However , RhoA *activation* by [TNF-alpha] was not blocked by inhibition . Negative_regulation TNF SPHK1 20036321 2200441 Suppression of by its inhibitor , N , N Dimethylsphingosine ( DMS ) , or siRNA *resulted* in decreased mRNA expression of [TNF-alpha] , IL-1beta , and iNOS and release of TNF-alpha and nitric oxide ( NO ) in LPS activated microglia . Negative_regulation TNF SPHK1 20577214 2280423 These results also highlight the key *role* of and its product S1P in [TNF-alpha] signalling and the canonical NF-kappaB activation pathway important in inflammatory , antiapoptotic and immune processes . Negative_regulation TNF SPHK2 10944534 744117 Activation of endogenous SK activity by [tumor necrosis factor-alpha (TNFalpha)] , interleukin-1beta , and phorbol esters in HEK293T cells was *blocked* by expression of this inactive ( hSK ( G82D ) ) . Negative_regulation TNF SPHK2 17114809 1677167 However , RhoA *activation* by [TNF-alpha] was not blocked by inhibition . Negative_regulation TNF SQSTM1 11438547 843380 Although the *role* of receptor in [TNF] signaling is well established , the role of p80 is less clear . Negative_regulation TNF SRGN 18266269 1871880 [TNF] induction by Staphylococcus aureus or by Toll-like receptor (TLR)2 agonists ( di- and triacylated lipopeptides and LTA ) was also *inhibited* by 1200 , but not that induced by Escherichia coli or TLR4 agonists . Negative_regulation TNF SRL 12505729 1038259 PD analyses suggested that in NHS samples containing CsA+SRL ( n=5 ) , ( 1 ) PMA-Ionomycin stimulated T-cell expression of intracellular IL-2 , [TNF-alpha] , and IFN-gamma was *inhibited* by CsA , and minimally by , and ( 2 ) the two agents inhibited pokeweed mitogen ( PWM ) -stimulated B-cell expression of CD54 and CD95 , but not CD86 ( ICAM-1 , Fas antigen , and B7.2 ) , synergistically . Negative_regulation TNF SRP14 14761113 1182297 Oral reduced bone loss ( p = 0.036 , X-ray ; p = 0.061 , histometry ) and fibre loss , both on the ligatured ( p = 0.0047 ) and control ( p = 0.005 ) sides , and also *reduced* the level of [TNF-alpha] ( p = 0.0137 ) and corticosterone ( p = 0.048 ) induced by intraperitoneal endotoxin lipopolysaccharide (LPS) . Negative_regulation TNF SRP19 14761113 1182298 Oral reduced bone loss ( p = 0.036 , X-ray ; p = 0.061 , histometry ) and fibre loss , both on the ligatured ( p = 0.0047 ) and control ( p = 0.005 ) sides , and also *reduced* the level of [TNF-alpha] ( p = 0.0137 ) and corticosterone ( p = 0.048 ) induced by intraperitoneal endotoxin lipopolysaccharide (LPS) . Negative_regulation TNF SRP54 14761113 1182299 Oral reduced bone loss ( p = 0.036 , X-ray ; p = 0.061 , histometry ) and fibre loss , both on the ligatured ( p = 0.0047 ) and control ( p = 0.005 ) sides , and also *reduced* the level of [TNF-alpha] ( p = 0.0137 ) and corticosterone ( p = 0.048 ) induced by intraperitoneal endotoxin lipopolysaccharide (LPS) . Negative_regulation TNF SRP68 14761113 1182300 Oral reduced bone loss ( p = 0.036 , X-ray ; p = 0.061 , histometry ) and fibre loss , both on the ligatured ( p = 0.0047 ) and control ( p = 0.005 ) sides , and also *reduced* the level of [TNF-alpha] ( p = 0.0137 ) and corticosterone ( p = 0.048 ) induced by intraperitoneal endotoxin lipopolysaccharide (LPS) . Negative_regulation TNF SRP72 14761113 1182301 Oral reduced bone loss ( p = 0.036 , X-ray ; p = 0.061 , histometry ) and fibre loss , both on the ligatured ( p = 0.0047 ) and control ( p = 0.005 ) sides , and also *reduced* the level of [TNF-alpha] ( p = 0.0137 ) and corticosterone ( p = 0.048 ) induced by intraperitoneal endotoxin lipopolysaccharide (LPS) . Negative_regulation TNF SRP9 14761113 1182302 Oral reduced bone loss ( p = 0.036 , X-ray ; p = 0.061 , histometry ) and fibre loss , both on the ligatured ( p = 0.0047 ) and control ( p = 0.005 ) sides , and also *reduced* the level of [TNF-alpha] ( p = 0.0137 ) and corticosterone ( p = 0.048 ) induced by intraperitoneal endotoxin lipopolysaccharide (LPS) . Negative_regulation TNF SRR 16115897 1474178 Moreover , *inhibits* [tumor necrosis factor] release from macrophages isolated from LPStreated wild type mice but has no effect on cytokine release from MIFdeficient macrophages . Negative_regulation TNF SST 12447528 1018119 Plasma level of IL-6 was increased significantly 3 h after pancreatitis induction , but to a lesser extent in Group S-ANP , while *prevented* [TNFalpha] release ( IL-6 : Group ANP : 0 , 0 , 518+/-139 , 956+/-125 , 373+/-48 , and 122+/-37 pg/ml ; Negative_regulation TNF SST 17456366 1730197 can *inhibit* the level of serum IL-6 and [TNF-alpha] in septic shock induced by LPS and improve the survival rate . Negative_regulation TNF ST13 2663142 114515 In addition , polyclonal does not *block* either [TNF-alpha] or TNF-beta activities or recognize either on Western blots . Negative_regulation TNF STAT1 11835405 911413 Here , we report our investigation of the *role* of in [TNF] signaling using STAT1-deficient U3A and STAT1-stably transfected U3A-PSG91 cells . Negative_regulation TNF STAT1 15199060 1281073 This difference seemed to be underlain by differential induction of signal transducers and activators of transcription ( STAT ) activation in that , whereas flagellin and [TNFalpha] seemed to be equipotent activators of p38 mitogen activated protein kinase and nuclear factor-kappaB , flagellin *induced* substantially higher levels of and -3 tyrosine phosphorylation . Negative_regulation TNF STAT1 16635351 1552725 and STAT3 might be *involved* in the regulation of [TNF-alpha] gene expression , but not in TNF-alpha early release ( < 24 hours ) induced by HMGB1 stimulation in rat peritoneal macrophages . Negative_regulation TNF STAT1 19782030 2141214 LXR ligands inhibit neither STAT1 phosphorylation nor translocation to the nucleus but , rather , *inhibit* STAT1 binding to promoters and the expression of IRF1 , [TNFalpha] , and IL-6 , downstream effectors of STAT1 action . Negative_regulation TNF STAT3 15199060 1281074 This difference seemed to be underlain by differential induction of signal transducers and activators of transcription ( STAT ) activation in that , whereas flagellin and [TNFalpha] seemed to be equipotent activators of p38 mitogen activated protein kinase and nuclear factor-kappaB , flagellin *induced* substantially higher levels of tyrosine phosphorylation . Negative_regulation TNF STAT3 15749841 1379660 IL-10 independent activation by Toxoplasma gondii *mediates* suppression of IL-12 and [TNF-alpha] in host macrophages . Negative_regulation TNF STAT3 15749890 1379743 In vitro , IL-27 induced phosphorylation and *inhibited* [TNF] and IL-12 production in activated peritoneal macrophages , indicating a novel feedback mechanism by which IL-27 can modulate excessive inflammation . Negative_regulation TNF STAT3 16635351 1552726 STAT1 and might be *involved* in the regulation of [TNF-alpha] gene expression , but not in TNF-alpha early release ( < 24 hours ) induced by HMGB1 stimulation in rat peritoneal macrophages . Negative_regulation TNF STAT3 17194701 1702139 Our data show that activity can *suppress* both IL-6 and [tumor necrosis factor] production in lipopolysaccharide stimulated macrophages . Negative_regulation TNF STAT3 19299019 2064074 A newly developed specific inhibitor ( stattic ) blocked LPS mediated STAT3 tyrosine phosphorylation and *led* to inhibition of LPS mediated IL-1beta and IL-6 production but not [TNF-alpha] production . Negative_regulation TNF STAT6 10227996 610536 These data show that is *required* for the IL-4 mediated inhibition of the production of [TNF-alpha] and IL-12 stimulated by LPS alone , but that IL-4 also activates distinct , STAT6 independent mechanism(s) that inhibit the IFN-gamma mediated enhancement of IL-12 and TNF-alpha production . Negative_regulation TNF STAT6 10982806 752135 Transient expression of STAT6 in a STAT6-deficient cell line ( HEK 293 ) conferred sensitivity to IL-4 for *dependent* transcription and for repression of interferon-gamma (IFNgamma)/STAT1- and/or [tumor necrosis factor-alpha (TNFalpha)/NF-kappaB-driven] reporter gene expression . Negative_regulation TNF STAT6 11991671 938526 Like MDMac , interferon alpha (IFNalpha) treated monocytes expressed less IL-4 receptor gamma c chain , reduced levels of IL-4 activated and IL-4 could not *suppress* LPS induced [TNFalpha] production . Negative_regulation TNF STAT6 14638848 1176699 signaling induces tristetraprolin expression and *inhibits* [TNF-alpha] production in mast cells . Negative_regulation TNF STK19 1699085 141653 In addition , mAb <5G11> did not *inhibit* [TNF] production due to isolated lipid A stimulation , suggesting that mAb 5G11 neutralized LPS by binding primarily to the deep core region of LPS . Negative_regulation TNF STS 7678355 209888 The [TNF-alpha-] and PMA stimulated VCAM-1 expression is *inhibited* by the PKC and PKA inhibitor . Negative_regulation TNF STX1A 16041028 1437655 Here , we show that *induces* apoptosis in the undifferentiated myelogenous leukemia cell line THP-1 in the absence of [tumor necrosis factor alpha (TNF-alpha)] or death receptor ( TNF receptor or Fas ) expression . Negative_regulation TNF SULT1A1 23605514 2784064 Besides , significantly *inhibited* LPS induced [TNF-a] and IL-1ß release , as well as CD40 and TNF-a protein upregulation . Negative_regulation TNF SULT1A3 18700140 1961355 In addition , *suppressed* LPS induced [tumor necrosis factor-alpha] production by differentiated THP-1 cells . Negative_regulation TNF SUN1 19671449 2138752 In addition , *inhibited* not only the production of IL-4 and [TNF-alpha] in the Con A-induced hepatitis model but also that in vitro by murine splenocytes stimulated with alpha-galactosylceramide , an activator specific for NKT cells . Negative_regulation TNF SUN2 19671449 2138750 In addition , *inhibited* not only the production of IL-4 and [TNF-alpha] in the Con A-induced hepatitis model but also that in vitro by murine splenocytes stimulated with alpha-galactosylceramide , an activator specific for NKT cells . Negative_regulation TNF SUN3 19671449 2138753 In addition , *inhibited* not only the production of IL-4 and [TNF-alpha] in the Con A-induced hepatitis model but also that in vitro by murine splenocytes stimulated with alpha-galactosylceramide , an activator specific for NKT cells . Negative_regulation TNF SUN5 19671449 2138751 In addition , *inhibited* not only the production of IL-4 and [TNF-alpha] in the Con A-induced hepatitis model but also that in vitro by murine splenocytes stimulated with alpha-galactosylceramide , an activator specific for NKT cells . Negative_regulation TNF SYF2 8258144 238610 In addition , could not *inhibit* the production of IL1 and [TNF alpha] by normal adherent cells . Negative_regulation TNF SYT1 11948689 930240 Conversely , expression of the subunit of NF-kappaB *suppressed* [TNF-alpha-] , TRAIL- , and serum deprivation induced cell death . Negative_regulation TNF SYT1 15980040 1465287 Therefore , the goal of the present study was to examine the *role* of subunit phosphorylation in the regulation of [TNF-alpha] production in cultured neonatal ventricular myocytes . Negative_regulation TNF SYT1 18591781 1931387 Rg3 effectively reduced inflammatory cytokine expression in Abeta42 treated BV-2 , and *inhibited* the binding of NF-kappaB to its DNA consensus sequences , and significantly reduced the expression of [TNF-alpha] in activated microglia . Negative_regulation TNF SYT1 22155740 2542804 Administration of parthenolide significantly reduced the severity of DSS induced colitis as assessed by DAI and histological score , and resulted in downregulation of MPO activity and phospho-NF-?B expression by the blockade of phosphorylation and subsequent degradation of I?B protein , strikingly *reduced* the production of [TNF-a] and IL-1ß . Negative_regulation TNF TAB1 17052891 1683800 In this study , a critical *role* for in IL-1alpha or [TNFalpha] stimulated MAPK and NFkappaB activation was confirmed by inhibition of the nuclear accumulation of NFkappaB p65 and phosphorylated forms of c-Jun and p38 following siRNA mediated TAK1 silencing . Negative_regulation TNF TAB1 18316610 1880940 ( 411 ) expression also *inhibited* TGF-beta stimulated [tumor necrosis factor-alpha] and cyclooxygenase-2 expression in 4T1 cells . Negative_regulation TNF TAB3 17384642 1727705 The formation of Smad7-TAB2 and complexes *resulted* in the suppression of [TNF] signaling through the adaptors TRAF2 , TAB2 and/or TAB3 , and TAK1 . Negative_regulation TNF TAL1 12368119 995352 We , also , explored the effects of dexamethasone ( DEXA ) and of two *inhibitors* of [TNF-alpha] production , and pentoxifylline , on paw swelling . Negative_regulation TNF TAL1 23146038 2699682 At the same time , ( 150 or 450 mg/kg dose group ) could *reduce* the expression of [TNF-a] and TGF-ß1 in alveolar macrophage of rats with pulmonary fibrosis at either the protein or mRNA level . Negative_regulation TNF TAL2 12368119 995353 We , also , explored the effects of dexamethasone ( DEXA ) and of two *inhibitors* of [TNF-alpha] production , and pentoxifylline , on paw swelling . Negative_regulation TNF TAL2 23146038 2699683 At the same time , ( 150 or 450 mg/kg dose group ) could *reduce* the expression of [TNF-a] and TGF-ß1 in alveolar macrophage of rats with pulmonary fibrosis at either the protein or mRNA level . Negative_regulation TNF TANK 11402319 824848 Altered signaling by a form of TRAF2 , which lacks the ring finger domain ( TRAF2DeltaN ) , *increases* activities of p38 MAPK , ATF2 , and the level of [TNFalpha] expression . Negative_regulation TNF TANK 12796506 1120132 Both [TNF-alpha-] and TRAF2 mediated nuclear factor-kappaB (NF-kappaB) activations were *inhibited* by interaction . Negative_regulation TNF TANK 19810754 2159673 Our structural observation should prompt a re-evaluation of the *role* of in [TNFalpha] signaling and may indicate that TRAF2 associated proteins such as cIAPs may be the ubiquitin ligases for NF-kappaB signaling . Negative_regulation TNF TANK 20038584 2211142 In accord with the known inhibitory *role* of in the alternative NFkappaB pathway , TNFR2- , but not TNFR1-specific [TNF] induced depletion of cytosolic TRAF2 . Negative_regulation TNF TAPBP 11688940 876048 The also *resulted* in significantly higher PLF and hepatic [TNF] levels , higher splenic IFN levels , and lower plasma IL-8 levels at 6 hours after challenge compared with the STD-TPN . Negative_regulation TNF TAS1R3 19505677 2098205 These results may suggest that trehalose *inhibits* LPS induced production of IL-1beta and [TNF-alpha] in mouse peritoneal macrophages by inhibiting degradation of IkappaB-alphavia the trehalose receptor . Negative_regulation TNF TAT 11522182 852736 HIV type 1 *inhibits* [tumor necrosis factor] alpha induced repression of tumor necrosis factor receptor p55 and amplifies tumor necrosis factor alpha activity in stably tat transfected HeLa Cells . Negative_regulation TNF TAT 22189681 2518542 Histological , Western blot , and reverse transcription-polymerase chain reaction data demonstrated that silk fibroin peptide or alone could *suppress* elevated levels of cyclooxygenase-2 , interleukin-6 , interleukin-1beta , and [tumor necrosis factor-alpha] induced by TPA . Negative_regulation TNF TAT 8806505 382308 Here we show that because of this similarity of mechanisms , the expression of an RNA species encoding polymeric-TAR sequences and known to inhibit Tat mediated HIV-1 gene expression also blocks [TNF] gene expression in *response* to , but not TNF promoter activation induced by human T cell leukemia/lymphotropic virus type I Tax protein . Negative_regulation TNF TAT 9715838 527825 It was proposed that the mechanism of antiviral action of S9a was on the host cell , by blocking [TNF-alpha] transcription via a *induced* tar independent loop , which decreases downstream NF-kappaB activation of HIV-1 long terminal repeat ( LTR ) . Negative_regulation TNF TAT 9758732 536308 Methylprednisolone treatment effectively inhibited the increases in [TNF-alpha] and IL-6 and the decreases in AT-III and albumin , but did not *inhibit* the increases in PMN-elastase and levels . Negative_regulation TNF TBL1XR1 20157051 2221865 also *reduced* monocyte chemoattractant protein 1 and [tumor necrosis factor-alpha] in vitro and in bleomycin induced toxic cutaneous inflammation in vivo . Negative_regulation TNF TBL1XR1 21189405 2378925 In contrast , *caused* significant decrease in renal [TNF-a] , IL-6 , TGF-ß1 and an increase in NO and cGMP levels . Negative_regulation TNF TBL2 15182636 1255794 200 mg/L and 100 mg/L could obviously *inhibit* IFN-gamma and [TNF-alpha] expressions in T lymphocytes . Negative_regulation TNF TBL3 15182636 1255795 200 mg/L and 100 mg/L could obviously *inhibit* IFN-gamma and [TNF-alpha] expressions in T lymphocytes . Negative_regulation TNF TBP 12561198 1029292 The data show that and TBP3 can *inhibit* 90 % of [TNF-alpha] activity when TNF-alpha gives about 30 % cell toxicity on L929 . Negative_regulation TNF TBXA2R 21075851 2376661 Interestingly , we found that activation of E-prostanoid (EP)2 and EP4 receptors , but not EP1 , EP3 , PGI(2) receptor ( IP ) , ( TP ) , PGD(2) receptor ( DP ) , and PGF ( 2 ) receptor ( FP ) , efficiently *blocked* LPS induced [tumor necrosis factor a (TNFa)] synthesis and COX-2 and mPGES-1 induction as well as prostaglandin synthesis in spinal cultures . Negative_regulation TNF TCF12 16455676 1534310 The aim of the present study is to examine whether this vitamin D inhibition of [TNFalpha] is *mediated* by its major , nuclear factor-kappaB (NFkappaB) . Negative_regulation TNF TCF15 16455676 1534311 The aim of the present study is to examine whether this vitamin D inhibition of [TNFalpha] is *mediated* by its major , nuclear factor-kappaB (NFkappaB) . Negative_regulation TNF TCF19 16455676 1534312 The aim of the present study is to examine whether this vitamin D inhibition of [TNFalpha] is *mediated* by its major , nuclear factor-kappaB (NFkappaB) . Negative_regulation TNF TCF20 16455676 1534313 The aim of the present study is to examine whether this vitamin D inhibition of [TNFalpha] is *mediated* by its major , nuclear factor-kappaB (NFkappaB) . Negative_regulation TNF TCF21 16455676 1534314 The aim of the present study is to examine whether this vitamin D inhibition of [TNFalpha] is *mediated* by its major , nuclear factor-kappaB (NFkappaB) . Negative_regulation TNF TCF23 16455676 1534318 The aim of the present study is to examine whether this vitamin D inhibition of [TNFalpha] is *mediated* by its major , nuclear factor-kappaB (NFkappaB) . Negative_regulation TNF TCF24 16455676 1534320 The aim of the present study is to examine whether this vitamin D inhibition of [TNFalpha] is *mediated* by its major , nuclear factor-kappaB (NFkappaB) . Negative_regulation TNF TCF25 16455676 1534319 The aim of the present study is to examine whether this vitamin D inhibition of [TNFalpha] is *mediated* by its major , nuclear factor-kappaB (NFkappaB) . Negative_regulation TNF TCF3 16455676 1534315 The aim of the present study is to examine whether this vitamin D inhibition of [TNFalpha] is *mediated* by its major , nuclear factor-kappaB (NFkappaB) . Negative_regulation TNF TCF4 16455676 1534316 The aim of the present study is to examine whether this vitamin D inhibition of [TNFalpha] is *mediated* by its major , nuclear factor-kappaB (NFkappaB) . Negative_regulation TNF TCF7 16455676 1534317 The aim of the present study is to examine whether this vitamin D inhibition of [TNFalpha] is *mediated* by its major , nuclear factor-kappaB (NFkappaB) . Negative_regulation TNF TCHH 11129814 760056 We hypothesize that *reduces* ischemia and reperfusion induced hepatic necrosis , PMN infiltration , [TNF-alpha] release , and consequent acute pulmonary injury . Negative_regulation TNF TCHH 11129814 760057 In addition , *reduces* the serum levels of [TNF-alpha] and associated pulmonary injury . Negative_regulation TNF TDGF1P3 22232682 2550995 Interestingly , the absence of *leads* to marked increases in the production of [TNF] in vitro and in vivo , despite reduced spirochetal uptake . Negative_regulation TNF TDRD7 16176655 1457797 significantly *inhibited* [TNF] production by LPS stimulated RAW 264.7 cells . Negative_regulation TNF TECR 18235000 1864338 [TNF-alpha] *induced* a decrease in the of HCE cells in a concentration- and time dependent manner . Negative_regulation TNF TFDP1 21140097 2358022 While 3-ethyl- and <3-propyl-TFDP> did not *reduce* baker 's yeast induced increases of IL-1ß or [TNF-a] levels , 3-ethyl-TFDP caused a 42 % reduction in peritoneal leukocyte count . Negative_regulation TNF TFDP2 21140097 2358023 While 3-ethyl- and <3-propyl-TFDP> did not *reduce* baker 's yeast induced increases of IL-1ß or [TNF-a] levels , 3-ethyl-TFDP caused a 42 % reduction in peritoneal leukocyte count . Negative_regulation TNF TFDP3 21140097 2358024 While 3-ethyl- and <3-propyl-TFDP> did not *reduce* baker 's yeast induced increases of IL-1ß or [TNF-a] levels , 3-ethyl-TFDP caused a 42 % reduction in peritoneal leukocyte count . Negative_regulation TNF TFG 18051909 1833274 *inhibited* the secretion of [TNF-alpha] from myocardial cells and increased the survival rate of myocardial cells . Negative_regulation TNF TFPI 11776329 890644 We recently reported that recombinant ( r-TFPI ) , an important inhibitor of the extrinsic pathway of the coagulation system , *inhibits* [TNF-alpha] production by monocytes . Negative_regulation TNF TFPI 8609227 352768 EPI-3 inhibited LPS induced in vivo TNF appearance and also increased IL-10 release ( both P < 0.005 versus LPS ) , whereas only *attenuated* [TNF] secretion ( P = 0.05 ) . Negative_regulation TNF TFPT 15499968 1326843 In addition , an increase in caspase 3 activity was observed after addition of for 1 h. Calphostin C *prevented* both the FB1 induced increase in [TNFalpha] expression and caspase 3 activation . Negative_regulation TNF TGFB1 10644003 577707 Thus , tyrosinase activity and the rate of melanin formation in B16 melanocytes might reflect simply the balance between alpha-MSH stimulation and or [TNF alpha] *inhibition* , acting by independent mechanisms . Negative_regulation TNF TGFB1 10880840 709212 *induced* IL-10 production , slightly decreased [TNF-alpha] production and decreased IFN-gamma production . Negative_regulation TNF TGFB1 11686517 875866 Moreover , we demonstrated that M. furfur modulates proinflammatory and immunomodulatory cytokine synthesis by downregulating IL-1alpha and by *inhibiting* IL-6 and [TNF-alpha] and by upregulating IL-10 and . Negative_regulation TNF TGFB1 12237848 989222 *blocked* the induction of the tyrosine kinases , Cox-2 , and the induction of IL-6 and [TNFalpha] mRNAs . Negative_regulation TNF TGFB1 1429677 202677 and interleukin (IL)-10 *inhibited* lipopolysaccharide (LPS) induced macrophage production of the inflammatory cytokines [tumor necrosis factor-alpha (TNF)] , IL-1 alpha , and IL-1 beta by contrasting post-transcriptional mechanisms . Negative_regulation TNF TGFB1 1730779 181314 [Tumor necrosis factor] stimulates DNA synthesis of mouse hepatocytes in primary culture and is *suppressed* by and interleukin 6 . Negative_regulation TNF TGFB1 1829411 161310 ( TGF-beta 1 ) mediates many immunosuppressive effects on immune cells and can *inhibit* the production of [tumor necrosis factor] and interleukin 1 (IL 1) . Negative_regulation TNF TGFB1 18475695 407244 *Role* of in down regulating [TNF] production by alveolar macrophages during asbestos induced pulmonary fibrosis . Negative_regulation TNF TGFB1 19351843 2057710 However , in HNSCC cells that retained residual TGFbeta signaling , *inhibited* both constitutive and [tumor necrosis factor] alpha stimulated NF-kappaB activity . Negative_regulation TNF TGFB1 20014292 2241047 *activated* kinase 1 signaling pathways regulate [TNF-alpha] production by titanium alloy particles in RAW 264.7 cells . Negative_regulation TNF TGFB1 20067543 2177771 Here we demonstrate that tumour derived prostaglandin E2 ( PGE ( 2 ) ) and ( TGF-beta ) increase interleukin-8 (IL-8) but synergistically *inhibit* interferon-alpha (IFN-alpha) and [tumour necrosis factor (TNF)] production of Toll-like receptor 7 (TLR7)- and Toll-like receptor 9 (TLR9) stimulated PDC . Negative_regulation TNF TGFB1 20491901 2276313 The anti-inflammatory cytokine ( TGF-beta1 ) , which is involved in the homeostatic regulation of TNF-alpha , *causes* post-transcriptional suppression of lipopolysaccharide (LPS) induced [TNF-alpha] production . Negative_regulation TNF TGFB1 20491901 2276314 Using RAW 264.7 cells and bone marrow derived macrophages ( BMDMphi ) stimulated with LPS and TGF-beta1 , we show that *inhibits* [TNF-alpha] protein secretion , whereas TNF-alpha mRNA expression remains unchanged . Negative_regulation TNF TGFB1 2104224 150526 Previous studies have indicated that the cytokine ( TGF beta 1 ) has immunosuppressive properties and can *inhibit* the production of [tumor necrosis factor (TNF)] and Interleukin 1 (IL 1) by human peripheral blood mononuclear cells . Negative_regulation TNF TGFB1 2201470 140464 This was confirmed by the observation that neither or TGF-beta 2 *inhibited* spontaneous IL-1 or [TNF-alpha] production by rheumatoid synovial mononuclear cells in culture . Negative_regulation TNF TGFB1 7526034 277070 CD34 expression of this cell line and the ability of to *inhibit* the [TNF-alpha] induction of E-selectin was examined . Negative_regulation TNF TGFB1 7526034 277075 C11STH cells do not express CD34 or show *inhibition* of [TNF-alpha] induced E-selectin expression , functions indicative of primary , or early passage HUVECs . Negative_regulation TNF TGFB1 7572286 328886 In this study , we demonstrate that ( TGF-beta ) , interleukin-10 (IL-10) and interleukin-6 (IL-6) *inhibit* [tumor necrosis factor-alpha] expression by primary rat astrocytes . Negative_regulation TNF TGFB1 7636180 317378 Exogenous bioactive *inhibited* NK cell DNA synthesis and production of IFN-gamma , [TNF-alpha] , and granulocyte-macrophage CSF (GM-CSF) by NK cultures consisting of > 98 % CD56+ cells . Negative_regulation TNF TGFB1 8864135 388935 ( TGF-beta ) also *inhibited* [TNF-alpha] and NO but did not affect IL-12 secretion . Negative_regulation TNF TGFB1 9070612 419708 *inhibits* the release of histamine and [tumor necrosis factor-alpha] from mast cells through an autocrine pathway . Negative_regulation TNF TGFB1 9369823 464060 Interleukin-10 and *inhibit* amniochorion [tumor necrosis factor-alpha] production by contrasting mechanisms of action : therapeutic implications in prematurity . Negative_regulation TNF TGFB2 1429677 202678 and interleukin (IL)-10 *inhibited* lipopolysaccharide (LPS) induced macrophage production of the inflammatory cytokines [tumor necrosis factor-alpha (TNF)] , IL-1 alpha , and IL-1 beta by contrasting post-transcriptional mechanisms . Negative_regulation TNF TGFB2 1730779 181315 [Tumor necrosis factor] stimulates DNA synthesis of mouse hepatocytes in primary culture and is *suppressed* by and interleukin 6 . Negative_regulation TNF TGFB2 20014292 2241048 *activated* kinase 1 signaling pathways regulate [TNF-alpha] production by titanium alloy particles in RAW 264.7 cells . Negative_regulation TNF TGFB2 20067543 2177772 Here we demonstrate that tumour derived prostaglandin E2 ( PGE ( 2 ) ) and ( TGF-beta ) increase interleukin-8 (IL-8) but synergistically *inhibit* interferon-alpha (IFN-alpha) and [tumour necrosis factor (TNF)] production of Toll-like receptor 7 (TLR7)- and Toll-like receptor 9 (TLR9) stimulated PDC . Negative_regulation TNF TGFB2 2201470 140465 This was confirmed by the observation that neither TGF-beta 1 or *inhibited* spontaneous IL-1 or [TNF-alpha] production by rheumatoid synovial mononuclear cells in culture . Negative_regulation TNF TGFB2 7526034 277071 CD34 expression of this cell line and the ability of to *inhibit* the [TNF-alpha] induction of E-selectin was examined . Negative_regulation TNF TGFB2 7526034 277076 C11STH cells do not express CD34 or show *inhibition* of [TNF-alpha] induced E-selectin expression , functions indicative of primary , or early passage HUVECs . Negative_regulation TNF TGFB2 7572286 328887 In this study , we demonstrate that ( TGF-beta ) , interleukin-10 (IL-10) and interleukin-6 (IL-6) *inhibit* [tumor necrosis factor-alpha] expression by primary rat astrocytes . Negative_regulation TNF TGFB2 8864135 388936 ( TGF-beta ) also *inhibited* [TNF-alpha] and NO but did not affect IL-12 secretion . Negative_regulation TNF TGFB2 9369823 464061 Interleukin-10 and *inhibit* amniochorion [tumor necrosis factor-alpha] production by contrasting mechanisms of action : therapeutic implications in prematurity . Negative_regulation TNF TGFB3 1429677 202679 and interleukin (IL)-10 *inhibited* lipopolysaccharide (LPS) induced macrophage production of the inflammatory cytokines [tumor necrosis factor-alpha (TNF)] , IL-1 alpha , and IL-1 beta by contrasting post-transcriptional mechanisms . Negative_regulation TNF TGFB3 1730779 181316 [Tumor necrosis factor] stimulates DNA synthesis of mouse hepatocytes in primary culture and is *suppressed* by and interleukin 6 . Negative_regulation TNF TGFB3 20014292 2241049 *activated* kinase 1 signaling pathways regulate [TNF-alpha] production by titanium alloy particles in RAW 264.7 cells . Negative_regulation TNF TGFB3 20067543 2177773 Here we demonstrate that tumour derived prostaglandin E2 ( PGE ( 2 ) ) and ( TGF-beta ) increase interleukin-8 (IL-8) but synergistically *inhibit* interferon-alpha (IFN-alpha) and [tumour necrosis factor (TNF)] production of Toll-like receptor 7 (TLR7)- and Toll-like receptor 9 (TLR9) stimulated PDC . Negative_regulation TNF TGFB3 7526034 277072 CD34 expression of this cell line and the ability of to *inhibit* the [TNF-alpha] induction of E-selectin was examined . Negative_regulation TNF TGFB3 7526034 277077 C11STH cells do not express CD34 or show *inhibition* of [TNF-alpha] induced E-selectin expression , functions indicative of primary , or early passage HUVECs . Negative_regulation TNF TGFB3 7572286 328888 In this study , we demonstrate that ( TGF-beta ) , interleukin-10 (IL-10) and interleukin-6 (IL-6) *inhibit* [tumor necrosis factor-alpha] expression by primary rat astrocytes . Negative_regulation TNF TGFB3 8864135 388937 ( TGF-beta ) also *inhibited* [TNF-alpha] and NO but did not affect IL-12 secretion . Negative_regulation TNF TGFB3 9369823 464062 Interleukin-10 and *inhibit* amniochorion [tumor necrosis factor-alpha] production by contrasting mechanisms of action : therapeutic implications in prematurity . Negative_regulation TNF TGM4 16671549 1558581 Meanwhile , also *suppressed* the excessive synoviocyte proliferation and over production of IL-1 , [TNFalpha] and PGE2 . Negative_regulation TNF THBD 10602073 655227 Basal expression of was largely comparable for all three cell types grown on different surfaces , but [TNFalpha] *suppressed* thrombomodulin to different extents depending on the origin of the EC . Negative_regulation TNF THBD 1847620 153486 Kinetic studies showed that for all stimuli the increase in tissue factor was transient , reaching a maximum after 4-8 h of preincubation with the stimulating agent and returning to normal values after 24 h . IL-1 and [TNF] *induced* a time dependent decrease in , by respectively 47 % and 67 % of control values after 24 h . Negative_regulation TNF THEM4 21282635 2393013 Both FFAs and [TNF] *induce* an Akt inhibitor , ( CTMP ) . Negative_regulation TNF TIA1 16820934 1581606 While HuR stabilizes TNF-alpha mRNA and enhances TNF-alpha production , acts as a post-transcriptional silencer , and *suppresses* the production of the [TNF-alpha] protein . Negative_regulation TNF TIA1 18438838 1915445 T cell intracytoplasmic antigen 1 ( TIA-1 ) and are *involved* in posttranscriptional regulation of the expression of [tumor necrosis factor alpha (TNFalpha)] and other proteins . Negative_regulation TNF TIMP1 10197169 561077 Articular cartilage from multiparous rabbits showed a significant decrease in mRNA levels for relevant molecules such as type II collagen , biglycan , collagenase and tissue *inhibitors* of metalloproteinases ( ) -1 , as well as necrosis factor-alpha ( [TNF-alpha] ) , inducible nitric oxide synthase (iNOS) and cyclo-oxygenase 2 (COX-2) . Negative_regulation TNF TIMP1 11162616 782288 We previously reported that [tumor necrosis factor-alpha] converting enzyme ( TACE ) was specifically *inhibited* by TIMP-3 but not , -2 , and -4 . Negative_regulation TNF TIMP1 12604910 1062732 The serum levels of matrix metalloproteinase (MMP)-1 , tissue *inhibitor* of metalloproteinases ( ) -1 , the MMP-1 . TIMP-1 complex , [tumor necrosis factor (TNF)-alpha] , and transfer growth factor (TGF)-beta1 were determined by enzyme linked immunosorbent assay . Negative_regulation TNF TIMP1 14991903 1215635 Activated matrix metalloproteinase (MMP)-1 , MMP-3 , MMP-13 , tissue *inhibitor* of metalloproteinases ( ) -1 , TIMP-2 , interleukin (IL)-1beta , IL-6 , and [tumour necrosis factor-alpha (TNF-alpha)] were measured in culture supernatants by enzyme linked immunosorbent assays , nitric oxide with the Griess reagent , and cell proliferation by [ 3H ] thymidine incorporation . Negative_regulation TNF TIMP1 15292059 1322179 As confirmed by reverse transcription-polymerase chain reaction ( RT-PCR ) , loss of IFN-gamma results in down-regulation of [tumor necrosis factor-alpha (TNF-alpha)] and tissue *inhibitor* of matrix metalloproteinase-1 ( ) while up-regulating expression of vascular endothelial growth factor ( VEGF ) and tenascin C . Negative_regulation TNF TIMP1 15581686 1355916 The results of the present study shows that treatment of BV reversed the LPS induced upregulation of such genes as interleukin-6 (IL-6) receptor , matrix metalloproteinase 15 (MMP-15) , [tumor necrosis factor] ( ligand ) superfamily-10 , caspase-6 and tissue *inhibitor* of metalloproteinase-1 ( ) . Negative_regulation TNF TIMP1 16333657 1533153 The samples were analysed for interleukin (IL)-1beta , [tumour necrosis factor (TNF)-alpha] , IL-6 , matrix metalloproteinase (MMP)-3 , and tissue *inhibitor* of metalloproteinase ( ) -1 using commercially available sandwich enzyme linked immunosorbent assay . Negative_regulation TNF TIMP1 16806998 1645996 This study aims to investigate the effects of HMW-HA on the gene expression of 16 OA-associated cytokines and enzymes , including interleukin (IL)-1beta , IL-6 , IL-8 , leukemia inhibitory factor (LIF) , [tumor necrosis factor (TNF)-alpha] , TNF-alpha converting enzyme (TACE) , matrix metalloproteinase (MMP)-1 , MMP-2 , MMP-3 , MMP-9 , MMP-13 , tissue *inhibitor* of metalloproteinase ( ) -1 , TIMP-2 , aggrecanase-1 , aggrecanase-2 , and inducible nitric oxide synthase (iNOS) , in fibroblast-like synoviocytes ( FLS ) from patients with early stage OA . Negative_regulation TNF TIMP1 17082335 1643196 In the majority of synovial fluid samples , angiogenin (Ang) , fibroblast growth factor (FGF)-9 , insulin-like growth factor binding protein ( IGFBP)-3 , interleukin (IL)-1alpha , IL-1beta , IL-8 , inducible protein (IP)-10 , macrophage inflammatory protein (MIP)-1beta , osteoprotegerin (OPG) , transforming growth factor (TGF)-beta2 , tissue *inhibitor* of metalloproteinase ( ) -1 , TIMP-2 , [tumour necrosis factor (TNF)-beta] and vascular endothelial growth factor ( VEGF ) were detectable . Negative_regulation TNF TIMP1 17589947 1764500 To study the ( functional ) relevance of single nucleotide polymorphisms ( SNPs ) in genes encoding matrix metalloproteinases (MMP)-1 , -2 , -3 , -9 , tissue *inhibitors* of metalloproteinases ( ) -1 , -2 and [tumor necrosis factor (TNF)-alpha] in the etiopathogenesis of inflammatory bowel diseases (IBD) , that may enhance susceptibility and/or disease severity . Negative_regulation TNF TIMP1 18197923 1857176 Measurements of WCC , serum levels of fibrinogen , high-sensitivity ( hs ) -CRP , IL-8 , IL-6 , [tumour necrosis factor-alpha (TNF-alpha)] , transforming growth factor (TGF)-beta1 , tissue *inhibitors* of metalloproteinase ( ) -1 , neutrophil elastase and alpha1-antitrypsin (alpha1-AT) were performed . Negative_regulation TNF TIMP1 18261936 1944000 For completeness , interleukin (IL)-6 , IL-1beta , matrix metalloproteinase (MMP)-2 , MMP-3 , MMP-9 , tissue *inhibitor* of metalloproteinase ( ) -1 , prostaglandin E2 ( PGE2 ) , leukotriene B4 (LTB4) , [tumor necrosis factor alpha (TNF)-alpha] and monocyte chemoattractant protein-1 ( MCP-1 ) accumulation have been evaluated in adiponectin stimulated chondrocytes cell culture supernatants . Negative_regulation TNF TIMP1 18263696 1924673 After CCl ( 4 ) treatment , the mRNA level of A ( 1 ) , A ( 2A ) , A ( 2B ) , and A ( 3 ) adenosine receptors , [tumor necrosis factor-alpha] , interleukin (IL) -1beta , IL-13r alpha1 , matrix metalloproteinase (MMP)-2 , MMP-14 , tissue *inhibitor* of metalloproteinase ( ) -1 , and TIMP-2 , and IL-13 level increased markedly in both CD73KO and WT mice , but Col1 alpha1 , Col3 alpha1 , and transforming growth factor-beta1 mRNA increased much more in WT mice than that in KO mice . Negative_regulation TNF TIMP1 18410971 1914310 To determine the pathogenesis of the central nervous system ( CNS ) involvement in HUS by EHEC , we determined the serum concentrations of interleukin-6 (IL-6) , tumor necrosis factor-alpha (TNF-alpha) , soluble [TNF] receptor 1 ( sTNFR1 ) , IL-10 , interferon-gamma (IFN-gamma) , IL-2 , IL-4 , soluble E-selectin ( sE-selectin ) , matrix metalloproteinase-9 (MMP-9) , and tissue *inhibitor* of metalloproteinase-1 ( ) during the acute stage in children with HUS with or without CNS involvement . Negative_regulation TNF TIMP1 18592988 1931424 Measurements of WCC , serum levels of fibrinogen , high-sensitivity c-reactive protein ( hs-CRP ) , interleukin-8 (IL-8) , interleukin-6 (IL-6) , [tumour necrosis factor-alpha (TNF-alpha)] , transforming growth factor (TGF)-beta1 , tissue *inhibitors* of metalloproteinase ( ) -1 , neutrophil elastase and alphal-antitrypsin ( alpha1-AT ) were done . Negative_regulation TNF TIMP1 19320885 2052441 Metalloproteinase-2 ( MMP-2 ) , MMP-9 , tissue *inhibitor* of metalloproteinase-1 ( ) , and [tumor necrosis factor-alpha (TNF-alpha)] were measured on days 2 and 7 using immunohistochemistry . Negative_regulation TNF TIMP1 20237245 2272977 Quantitative real-time PCR was performed to measure the expression of [tumor necrosis factor-alpha (TNF)] , interleukin-1beta (IL1B) , matrix metalloproteinase-1 (MMP1) , MMP-2 , MMP-9 , tissue *inhibitor* of matrix metalloproteinase 1 ( ) , TIMP-2 , and hypoxanthine phosphoribosyl transferase-1 ( HPRT1 ) . Negative_regulation TNF TIMP1 20298300 2009511 We used commercially available enzyme linked immunosorbent assay kits to measure the plasma levels of [tumour necrosis factor-alpha (TNF-alpha)] , interleukin-8 (IL-8) , matrix metalloproteinase-9 (MMP-9) , monocyte chemotactic protein-1 (MCP-1) , tissue *inhibitor* of metalloproteinase-1 ( ) and tissue inhibitor of metalloproteinase-2 ( TIMP-2 ) on two occasions with a 2-week interval in patients with COPD ( n = 20 ) , asymptomatic smokers ( n = 10 ) and healthy lifelong non-smokers ( n = 10 ) . Negative_regulation TNF TIMP1 21199330 2493926 The mRNA levels of tumour necrosis factor (TNF)-a and protein levels of p38 , cytosolic phospolipase A2 and cyclooxygenase 2 were significantly increased in the D DSS ( + ) pups and were accompanied by a decrease in the protein level of tissue *inhibitor* of metalloproteinases ( ) 3 , a negative regulator of [TNF-a] . Negative_regulation TNF TIMP1 22245747 2605632 Serum group animals were used to measure porcine-specific tumour necrosis factor-alpha ( [TNF-a] ) , interleukin ( IL-6 , IL-10 ) , matrix metalloproteinase ( MMP9 ) , Aquaporin-4 (AQP4) , tissue *inhibitor* to metalloproteinase-1 ( ) , neuron-specific enolase (NSE) and S100B at 0.5 h , 6 h , 12 h , 24 h and 72h recovery by enzyme linked immunosorbent assay ( ELISA ) . Negative_regulation TNF TIMP1 23122666 2780384 Wound sections were analyzed by immunostaining for metalloproteinase ( MMP) 2 , MMP7 , MMP9 , tissue *inhibitor* of metalloproteinases ( ) 1 , and [tumor necrosis factor (TNF)] a on days 2 , 4 , and 12 . Negative_regulation TNF TIMP1 23318412 2742353 The rat body weight , hydroxyproline levels in serum and lung , pathological changes of lung , as well as mRNA and protein expressions of matrix metalloproteinase-9 (MMP-9) , tissue *inhibitor* of metalloproteinase-1 ( ) and [tumor necrosis factor-a (TNF-a)] in rat lung tissues were analyzed . Negative_regulation TNF TIMP1 23485615 2771906 Reverse transcription polymerase chain reaction ( RT-PCR ) and western blot analyses revealed that CK inhibited DMN induced increases in matrix metalloproteinase-13 (MMP-13) , tissue *inhibitor* of metalloproteinase-1 ( ) , and [tumor necrosis factor-a (TNF-a)] mRNA , and collagen type I and a-smooth muscle actin protein . Negative_regulation TNF TIMP1 23977892 2832998 Aggrecan , collagen II , MMP-2 , MMP-3 , MMP-9 , MMP-13 , ADAM metallopeptidase with thrombospondin type 1 motif ( ADAMTS)-4 , ADAMTS-5 , tissue *inhibitor* of metalloproteinase ( ) -1 , TIMP-2 , TIMP-3 , interleukin-1ß , [tumor necrosis factor-a] , cyclooxygenase-1 , cyclooxygenase-2 , and inducible nitric oxide synthase gene expression were evaluated . Negative_regulation TNF TIMP1 8403497 232319 These results suggest that the cytokine effects on production are different among the different cell types , and that either IL-1 beta or [TNF-alpha] *induce* cartilage matrix degradation by disrupting the collagenase/TIMP balance , while , on the other hand , IL-6 protects the tissue through an opposite effect . Negative_regulation TNF TIMP1 8753775 377374 A matrix metalloproteinase did process [tumor necrosis factor-alpha] extracted from COS cells , but neither nor -2 *blocked* tumor necrosis factor-alpha processing by human monocytes . Negative_regulation TNF TIMP1 9731514 530475 The synthetic MMPIs and TIMP-2 , but not , also *caused* a dose dependent increase in the number of [TNFalpha] receptors retained on the surface of Colo 205 cells , as determined by flow cytometry . Negative_regulation TNF TIMP2 9731514 530476 The synthetic MMPIs and , but not TIMP-1 , also *caused* a dose dependent increase in the number of [TNFalpha] receptors retained on the surface of Colo 205 cells , as determined by flow cytometry . Negative_regulation TNF TIMP3 11162616 782289 We previously reported that [tumor necrosis factor-alpha] converting enzyme ( TACE ) was specifically *inhibited* by but not TIMP-1 , -2 , and -4 . Negative_regulation TNF TIMP3 15685464 1350960 In this study , we used a rodent femur model of intramedullary osseointegration to analyze the changes in immunoreactivity of ECM controlling matrix metalloproteinases ( MMPs ) , tissue *inhibitor* of metalloproteinase-3 ( ) , and [tumor necrosis factor alpha (TNF-alpha)] during osseointegration . Negative_regulation TNF TIMP3 19625257 2149902 We reported that the loss of ( tissue inhibitor of metalloproteinase 3 ) *leads* to abnormal [TNF] signaling and cardiovascular function . Negative_regulation TNF TIMP3 20715091 2312990 hVFF response to TNF-alpha was characterized by morphology , proliferation rates , and gene transcript levels for matrix metalloproteinase 1 (MMP1) , matrix metalloproteinase 2 (MMP2) , tissue *inhibitor* of metalloproteinase 3 ( ) , collagen I , collagen III , fibronectin , and [TNF-alpha] receptor . Negative_regulation TNF TIMP3 9755855 535709 [TNF-alpha converting enzyme (TACE)] is *inhibited* by . Negative_regulation TNF TJP1 20632386 2316659 Our results showed that GDNF resulted in a significant reduction in enhanced permeability , *inhibited* MPO activity , IL-1beta and [TNF-alpha] expression , and increased and Akt expression . Negative_regulation TNF TKT 11922921 926475 Furthermore , *inhibited* both IL-1beta and [TNF-alpha] secretion induced by PMA and A23187 , respectively . Negative_regulation TNF TLR1 16538507 1574439 binding *results* in cell signal transduction and subsequent production of various proinflammatory cytokines such as IL-1 and [TNF-alpha] . Negative_regulation TNF TLR10 16538507 1574447 binding *results* in cell signal transduction and subsequent production of various proinflammatory cytokines such as IL-1 and [TNF-alpha] . Negative_regulation TNF TLR2 10588727 572145 We identify toll-like receptor-2 (TLR2) as the specific toll-like receptor required for this induction by showing that expression of an inhibitory ( TLR2-P681H ) *blocks* [TNF-alpha] production induced by whole M. tuberculosis . Negative_regulation TNF TLR2 15664906 1365329 However , restimulation of MC with either PgLPS or EcLPS downregulates and TLR4 mRNA and protein and IL-1beta mRNA and *induces* a ca. 10-fold reduction in [TNF-alpha] secretion , suggesting the induction of endotoxin tolerance by either LPS . Negative_regulation TNF TLR2 15910421 1411964 The interaction of LPPG with and TLR4 *resulted* in activation of NF-kappaB and release of interleukin (IL)-10 , IL-12p40 , [tumour necrosis factor (TNF)-alpha] , and IL-8 from human monocytes . Negative_regulation TNF TLR2 16538507 1574440 binding *results* in cell signal transduction and subsequent production of various proinflammatory cytokines such as IL-1 and [TNF-alpha] . Negative_regulation TNF TLR2 17570324 1753746 Ketamine 2.5 , 5 and 10 mg/kg after CLP decreased intestinal [TNF-alpha] level and NF-kappaB activity , and *inhibited* and TLR4 expressions as well . Negative_regulation TNF TLR2 18261365 1839744 Ketamine at sub-anesthetic doses could suppress the production of inflammatory cytokines such as [TNF-alpha] and IL-6 , attenuate NF-kappaB activity , and *inhibit* and TLR4 expression in polymicrobial sepsis . Negative_regulation TNF TLR2 19572897 2104752 When BM-Mvarphi , obtained from diabetic NOD mice , are stimulated with P. gingivalis LPS under hyperglycemic conditions the following changes occur : reduced messenger RNA expression and cell surface expression of , *reduced* messenger RNA expression and protein production of [tumor necrosis factor-alpha] , reduced signal transduction , and a reduction in phagocytic function . Negative_regulation TNF TLR2 21396483 2453293 Artesunate not only inhibited [TNF-a] and IL-6 release but also *inhibited* mRNA and protein expressions of and Nod2 , two important receptors , in murine peritoneal macrophages stimulated with heat killed WHO-2 , further demonstrating anti-inflammatory effect of artesunate was related to the inhibition of TLR2- and Nod2 mediated proinflammatory cytokines . Negative_regulation TNF TLR2 22956655 2688279 Anti-inflammatory SMAMPs prevented the induction of [tumor necrosis factor (TNF)] , interleukin 6 (IL-6) , and IL-10 in *response* to S. aureus or LTA , but no other ligands . Negative_regulation TNF TLR2 23231043 2718594 The absence of *led* to lower production of the cytokines [TNF-a] , IL-1ß , IL-12 and IL-10 compared to WT animals . Negative_regulation TNF TLR2 24228579 2868702 Baicalin is able to specifically inhibit the expression of , *inhibit* the expression of inflammatory factors IL-1beta , IL-6 and [TNF-alpha] , and thereby reducing the injury of the tissue cells during the course of disease . Negative_regulation TNF TLR2 24846691 2945329 *blocking* significantly reduced [TNF-a] , IL-6 , IL-1ß and IL-10 and increased IFN-? and IL-12 production . Negative_regulation TNF TLR2 25172490 2957520 We show using reporter assays that signaling is dependent on pneumococcal lipoproteins , and that macrophage NF-?B activation and [TNF-a] release were *reduced* in response to the ?lgt strain . Negative_regulation TNF TLR3 16538507 1574441 binding *results* in cell signal transduction and subsequent production of various proinflammatory cytokines such as IL-1 and [TNF-alpha] . Negative_regulation TNF TLR3 20375303 2261816 Importantly , stimulation of Mk2 ( -/- ) cells through or TLR4 severely *impaired* [TNF-alpha] protein production but did not affect TNF-alpha mRNA induction . Negative_regulation TNF TLR4 15791840 1352662 Moreover , hsp70 induced [TNF-alpha] production by human monocytes was *inhibited* by . Negative_regulation TNF TLR4 15910421 1411965 The interaction of LPPG with TLR2 and *resulted* in activation of NF-kappaB and release of interleukin (IL)-10 , IL-12p40 , [tumour necrosis factor (TNF)-alpha] , and IL-8 from human monocytes . Negative_regulation TNF TLR4 16538507 1574442 binding *results* in cell signal transduction and subsequent production of various proinflammatory cytokines such as IL-1 and [TNF-alpha] . Negative_regulation TNF TLR4 16809643 1606037 We demonstrate that overexpression of *augmented* a LPS induced bronchoconstrictive effect , as well as [tumor necrosis factor] and CXC chemokine ligand 1 ( keratinocyte derived chemokine ) production . Negative_regulation TNF TLR4 16965747 1616046 HXR could down-regulate the expression of membrane receptor and *inhibit* the expressions of NF-kappaB and [TNF-alpha] . Negative_regulation TNF TLR4 16965747 1616050 QGHXR can protect liver cells by down regulating the expressions of CD14 , and NF-kappaB and *inhibiting* [TNF-alpha] expression . Negative_regulation TNF TLR4 17034424 1683079 In this study we have shown that , whilst NF-kappaB activation and production of [TNF-alpha] and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was *reduced* by prior stimulation with , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or interleukin-12 responses to subsequent TLR stimulation . Negative_regulation TNF TLR4 17570324 1753747 Ketamine 2.5 , 5 and 10 mg/kg after CLP decreased intestinal [TNF-alpha] level and NF-kappaB activity , and *inhibited* TLR2 and expressions as well . Negative_regulation TNF TLR4 18261365 1839745 Ketamine at sub-anesthetic doses could suppress the production of inflammatory cytokines such as [TNF-alpha] and IL-6 , attenuate NF-kappaB activity , and *inhibit* TLR2 and expression in polymicrobial sepsis . Negative_regulation TNF TLR4 18271077 1865803 Stimulation with TLR2 , and TLR7/8 ligands , as well as TLR3 ligand , *resulted* in significantly lower production of [TNF-alpha] , but neither IL-6 nor IL-12p70 , by DCs from XLA patients in comparison to normal controls . Negative_regulation TNF TLR4 18826950 1987986 In the current study , surface TLR4 expression were similar but activation ( lipid A , 10 microg/ml ) *resulted* in lower [TNF-alpha] release by HIV+ human macrophages compared with healthy cells . Negative_regulation TNF TLR4 19133650 2053772 In contrast , the absence of *had* no effect on the early , ethanol induced increase in either C3b or [TNF-alpha] . Negative_regulation TNF TLR4 20375303 2261817 Importantly , stimulation of Mk2 ( -/- ) cells through TLR3 or severely *impaired* [TNF-alpha] protein production but did not affect TNF-alpha mRNA induction . Negative_regulation TNF TLR4 20465519 2339621 Our results show that the absence of functional *resulted* in lower chemotaxis of neutrophils to the site of infection , lower levels of [TNF-a] , CXCL1 and nitric oxide , and dissemination and persistence of the pathogen in lymph nodes and spleen . Negative_regulation TNF TLR4 20472010 2288545 Human monocytes and macrophages secreted tumor necrosis factor (TNF)-alpha in response to mmLDL , and blocking CD14 or *resulted* in a approximately 60 % decrease in mmLDL induced [TNF-alpha] secretion . Negative_regulation TNF TLR4 20550956 2315745 *Role* for in [TNF-alpha] secretion by murine macrophages in response to polysaccharide Krestin , a Trametes versicolor mushroom extract . Negative_regulation TNF TLR4 21033154 2338862 To characterize the *role* of in silica induced production of [tumor necrosis factor alpha (TNFalpha)] from macrophage cell line . Negative_regulation TNF TLR4 21717809 2447274 As expected , induction of [TNF-alpha] and IL-6 by TLR4 agonist LPS was *inhibited* in a significant manner by but not by anti-TLR2 antibody . Negative_regulation TNF TLR4 22685319 2675977 Interestingly , despite expression of TLR mRNA on Kupffer cells , ligation of , TLR7/8 , and TLR9 *resulted* in a weak induction of IL-10 , low or undetectable levels of IL-12p40 and [TNF] , and up-regulation of CD40 on the surface . Negative_regulation TNF TLR4 24334457 2894933 CORM-2 decreased systemic inflammatory cytokines , suppressed systemic and pancreatic macrophage [TNF-a] secretion , and *inhibited* macrophage receptor complex expression . Negative_regulation TNF TLR4 24345260 2880877 Triptolide can ameliorate LPS induced ALI by reducing the release of the inflammatory mediator [TNF-a] and *inhibiting* expression . Negative_regulation TNF TLR5 16538507 1574443 binding *results* in cell signal transduction and subsequent production of various proinflammatory cytokines such as IL-1 and [TNF-alpha] . Negative_regulation TNF TLR6 16538507 1574448 binding *results* in cell signal transduction and subsequent production of various proinflammatory cytokines such as IL-1 and [TNF-alpha] . Negative_regulation TNF TLR7 16538507 1574444 binding *results* in cell signal transduction and subsequent production of various proinflammatory cytokines such as IL-1 and [TNF-alpha] . Negative_regulation TNF TLR7 18271077 1865804 Stimulation with TLR2 , TLR4 and ligands , as well as TLR3 ligand , *resulted* in significantly lower production of [TNF-alpha] , but neither IL-6 nor IL-12p70 , by DCs from XLA patients in comparison to normal controls . Negative_regulation TNF TLR7 22685319 2675978 Interestingly , despite expression of TLR mRNA on Kupffer cells , ligation of TLR4 , , and TLR9 *resulted* in a weak induction of IL-10 , low or undetectable levels of IL-12p40 and [TNF] , and up-regulation of CD40 on the surface . Negative_regulation TNF TLR8 16538507 1574445 binding *results* in cell signal transduction and subsequent production of various proinflammatory cytokines such as IL-1 and [TNF-alpha] . Negative_regulation TNF TLR8 20946625 2343629 Lower protein levels of in monocytes from RSV infected infants , compared to healthy infants , negatively correlated with respiratory frequency and *resulted* in lower [TNF-a] synthesis upon a specific TLR8 stimulation . Negative_regulation TNF TLR8 22393042 2581979 Epigenetic regulation of [tumor necrosis factor a (TNFa)] release in human macrophages by HIV-1 single stranded RNA ( ssRNA ) is *dependent* on signaling . Negative_regulation TNF TLR9 16402377 1513162 Since both RANKL-RANK and interactions *result* in NF-kappaB activation , p38 and ERK phosphorylation , and [TNF-alpha] synthesis ( all implicated in osteoclastogenesis ) , we hypothesized that CpG-ODN ( but not RANKL ) in addition induces the synthesis of an anti-osteoclastogenic factor . Negative_regulation TNF TLR9 16538507 1574446 binding *results* in cell signal transduction and subsequent production of various proinflammatory cytokines such as IL-1 and [TNF-alpha] . Negative_regulation TNF TLR9 22685319 2675979 Interestingly , despite expression of TLR mRNA on Kupffer cells , ligation of TLR4 , TLR7/8 , and *resulted* in a weak induction of IL-10 , low or undetectable levels of IL-12p40 and [TNF] , and up-regulation of CD40 on the surface . Negative_regulation TNF TMED7 20545441 2279491 Avian leukosis virus *inhibits* [tumor necrosis factor] alpha expression in RAW264.7 macrophages after stimulation with lipopolysaccharide . Negative_regulation TNF TMED7 20545441 2279492 It was found that the ALV expression markedly *reduced* the production of [TNF-alpha] , but did not affect the production of IL-1beta , IL-6 , and 12 , and cell proliferative activity . Negative_regulation TNF TMED7 20545441 2279494 These results demonstrate that ALV specifically *inhibits* [TNF-alpha] expression in the macrophages stimulated by LPS , suggesting a possible contribution of ALV p27 to immunosuppression detected in ALV infected hosts . Negative_regulation TNF TMEFF1 23495748 2818667 We also demonstrated that and TR2 significantly *attenuated* the malondialdehyde ( MDA ) , nitric oxide ( NO ) , [tumor necrosis factor] ( TNF-a ) , and interleukin-1ß (IL-1ß) levels in either edema paw or serum at the fifth hour after Carr injection . Negative_regulation TNF TMF1 24161485 2875419 *inhibits* the productions and mRNA expressions of [tumor necrosis factor-a (TNF-a)] , interleukin (IL)-1ß , and IL-6 induced by LPS . Negative_regulation TNF TNFAIP3 23032186 2681076 We thus propose a model in which *inhibits* [TNF-] and LUBAC induced NF-?B signalling by binding to linear polyubiquitin chains via its seventh zinc finger , which prevents the TNF induced interaction between LUBAC and NEMO . Negative_regulation TNF TNFAIP3 8692885 370797 also *inhibited* [TNF] and IL-1 induced NF-kappaB activation , suggesting that it may inhibit NF-kappaB activation signaled by diverse stimuli . Negative_regulation TNF TNFAIP3 9314949 455736 Both [TNF] + CHX and TNF+ cer killing are induced by a TNF mutein that only interacts with the type 1 TNF receptor , and both responses can be *inhibited* by the antiapoptotic protein . Negative_regulation TNF TNFRSF11A 16402377 1513160 Since both and CpG-ODN-TLR9 interactions *result* in NF-kappaB activation , p38 and ERK phosphorylation , and [TNF-alpha] synthesis ( all implicated in osteoclastogenesis ) , we hypothesized that CpG-ODN ( but not RANKL ) in addition induces the synthesis of an anti-osteoclastogenic factor . Negative_regulation TNF TNFRSF11B 20003323 2176608 Lewis rats with established AIA or CIA were treated for 10 days ( from day 4 post onset ) with either PBS ( Veh ) , [TNFalpha] *inhibitor* ( pegsunercept ) , IL-1 inhibitor ( anakinra ) , or RANKL inhibitor ( ) . Negative_regulation TNF TNFRSF11B 21992185 2519844 MSU crystals induced the expressions of IL-1 , IL-6 , [TNF-alpha] and RANKL in PBMCs , but *inhibited* expression . Negative_regulation TNF TNFRSF14 23495748 2818668 We also demonstrated that TR1 and significantly *attenuated* the malondialdehyde ( MDA ) , nitric oxide ( NO ) , [tumor necrosis factor] ( TNF-a ) , and interleukin-1ß (IL-1ß) levels in either edema paw or serum at the fifth hour after Carr injection . Negative_regulation TNF TNFRSF1A 10950109 723369 Unexpectedly , [TNF] responses were also *inhibited* by overexpressed and TNFR2 ( +DD ) , but not TNFR2 . Negative_regulation TNF TNFRSF1A 11509005 848223 The survival activity of [TNF-alpha] was *inhibited* by , anti-TNF-RII antagonist antibodies and anti-granulocyte-monocyte colony stimulating factor ( GM-CSF ) neutralizing antibodies but not by anti-interleukin (IL)-3 or anti-IL-5 antibodies . Negative_regulation TNF TNFRSF1A 11513085 849122 Preincubation with antibody against TNF receptor type 1 (TNFR1) or TNF receptor type 2 reduced the specific binding by 95 and 15 % , respectively , suggesting a dominating *role* of in 125I labeled [TNFalpha] ( 125I-TNFalpha ) binding . Negative_regulation TNF TNFRSF1A 11592999 869738 Photochemically enhanced binding of small molecules to the *inhibits* the binding of [TNF-alpha] . Negative_regulation TNF TNFRSF1A 16369129 1553928 Levels of the interleukin-1 receptor antagonist ( IL-1 RA ) , the soluble [tumor necrosis factor] receptor *inhibitor* ( ) and G-CSF were measured by ELISA . Negative_regulation TNF TNFRSF1A 17198691 1695568 From these studies we propose that the [TNF-alpha] inhibition of LTP is *dependent* upon the activation of and mGlu5-receptors . Negative_regulation TNF TNFRSF1A 17510296 1761918 We report ablated , soluble TNF-alpha , , and TNFRII production by neutrophils and macrophages stimulated with various microbial antigens and greatly *reduced* [TNF-alpha] levels in vivo following inflammation induction . Negative_regulation TNF TNFRSF1A 23341882 2733868 significantly *inhibited* LPS induced [TNF-a] production ( p < 0.05 ) . Negative_regulation TNF TNFRSF1A 23423194 2755343 Our findings suggest that the cytoprotective effects of HO-1 are *mediated* by suppression of [TNF/TNFR1] mediated apoptotic signaling , specifically by modulating apoptotic DISC formation and mitochondrial translocation during hepatic I/R . Negative_regulation TNF TNFRSF1A 8395024 228469 To investigate the *role* of in beneficial and detrimental activities of [TNF] , we generated TNFR1-deficient mice by gene targeting . Negative_regulation TNF TNFRSF1A 9433879 482452 Soluble *reduced* serum levels of [TNFalpha] and led to a 2-fold increase in the lifespan of me/me mice , compared with the control treatment group . Negative_regulation TNF TNFRSF1B 10950109 723370 Unexpectedly , [TNF] responses were also *inhibited* by overexpressed TNFR1 and ( +DD ) , but not TNFR2 . Negative_regulation TNF TNFRSF1B 11302411 803379 *inhibits* the activity of [tumor necrosis factor] and lymphotoxin-alpha . Negative_regulation TNF TNFRSF1B 11380043 820472 Therapies targeted to tumor necrosis factor alpha (TNF-alpha) include anti-TNF-alpha monoclonal antibodies ( infliximab and CDP-571 ) , TNF binding neutralizing fusion proteins ( ) , and [TNF-alpha] production *inhibitors* ( thalidomide ) . Negative_regulation TNF TNFRSF1B 11890650 894232 This study examined the effects of , a [TNF] *inhibitor* , in patients with PsA . Negative_regulation TNF TNFRSF1B 12113051 963758 ) and other agents inactivating or *blocking* [TNF-alpha] in the management of patients with hematologic malignancies . Negative_regulation TNF TNFRSF1B 12161090 971820 The Wegener 's Granulomatosis Etanercept Trial ( WGET ) is a randomized , double masked , placebo controlled trial designed to test the ability of , a soluble *inhibitor* of [tumor necrosis factor] , to maintain disease remission when used with conventional treatments . Negative_regulation TNF TNFRSF1B 12671515 1076258 It has been suggested that the formation of osteoclasts is influenced by [tumor necrosis factor-alpha] , which can be *blocked* by . Negative_regulation TNF TNFRSF1B 12715413 1083685 A new class of drugs has been developed : biologic response modifiers , two of which -- and infliximab -- *inhibit* [tumor necrosis factor] , a pivotal regulator of inflammation , and delay arthritic progression . Negative_regulation TNF TNFRSF1B 12749017 1089057 We report three consecutive patients with critical chronic refractory ITP , who responded promptly and completely following treatment with , an *inhibitor* of [tumor necrosis factor-alpha] . Negative_regulation TNF TNFRSF1B 12894133 1117911 , a competitive *inhibitor* of [TNF-alpha] , is currently FDA approved for psoriatic arthritis and rheumatoid arthritis . Negative_regulation TNF TNFRSF1B 14992426 1215667 The aim of this study was to determine the safety and efficacy of , an *inhibitor* of [tumor necrosis factor] , in the treatment of PSC . Negative_regulation TNF TNFRSF1B 15176161 1254945 is a human fusion protein of the tumor necrosis factor receptor (TNFR) and the Fc region of IgG1 that binds to and presumably *inhibits* the pro-inflammatory and pro-proliferative activity of the [tumor necrosis factor (TNF)] . Negative_regulation TNF TNFRSF1B 15180471 1255544 The [TNF-alpha] *inhibitors* , infliximab and , have been employed with success in moderate to severe psoriasis and in psoriatic arthritis in randomized controlled trials . Negative_regulation TNF TNFRSF1B 15306993 1284805 Tuberculosis following the use of , a [tumor necrosis factor] *inhibitor* . Negative_regulation TNF TNFRSF1B 15475440 1319214 A phase II study of ( Enbrel ) , a [tumor necrosis factor] alpha *inhibitor* in patients with metastatic breast cancer . Negative_regulation TNF TNFRSF1B 15898294 1408670 In this report , we present the case of a 65-year-old man with a 9-year history of recalcitrant ACH who demonstrated significant and sustained clinical improvement when , a competitive *inhibitor* of [TNF-alpha] , was added to his treatment regimen of acitretin and topical corticosteroids over a 12-week period . Negative_regulation TNF TNFRSF1B 15928633 1414307 In this prospective , open-label pilot study , we evaluated the safety and efficacy of , a [TNF-alpha] *inhibitor* , in the treatment of moderate to severe alopecia areata , alopecia totalis , or alopecia universalis . Negative_regulation TNF TNFRSF1B 16081850 1442859 Thus , *induced* [TNF/lymphotoxin] blockade may break the potentially self sustaining cycle of DC activation and maturation , subsequent T cell activation , and cytokine , growth factor , and chemokine production by multiple cell types including lymphocytes , neutrophils , DCs , and keratinocytes . Negative_regulation TNF TNFRSF1B 16135466 1450323 Study of , a [tumor necrosis factor-alpha] *inhibitor* , in recurrent ovarian cancer . Negative_regulation TNF TNFRSF1B 16391890 1581701 To verify this hypothesis , PBMC from healthy individuals were treated with plasma from active SLE patients in the presence or absence of , a [TNF] *inhibitor* . Negative_regulation TNF TNFRSF1B 16403479 1520438 To further evaluate the role of TNFalpha in I/R injury , a selective [TNFalpha] *inhibitor* ( ) was used in vitro before the ischemic insult . Negative_regulation TNF TNFRSF1B 16536817 1536565 TNF-alpha is implicated in many inflammatory disorders and we wished to determine the efficacy of subcutaneous , a competitive *inhibitor* of [TNF-alpha] in the control of HS symptoms . Negative_regulation TNF TNFRSF1B 16602610 1545052 Based on its mechanism of action , we propose an association between the use of , a [tumor necrosis factor alpha (TNF-alpha)] *inhibitor* , and this case of fatal pulmonary mycobacterial infection . Negative_regulation TNF TNFRSF1B 16630948 1552261 *prevents* soluble [TNF] from binding to its cell membrane receptor , leading to inhibition of its inflammatory cascade . Negative_regulation TNF TNFRSF1B 16699531 1570064 Combination antithymocyte globulin and soluble [TNFalpha] *inhibitor* ( ) +/- mycophenolate mofetil for treatment of steroid refractory acute graft-versus-host disease . Negative_regulation TNF TNFRSF1B 16864744 1600622 Female rats approaching reproductive senescence ( 12 to 15 months old ) were ovariectomized and treated with placebo , estrogen , or a selective [TNF-alpha] *inhibitor* ( ) for 4 weeks . Negative_regulation TNF TNFRSF1B 16939569 1609303 Therefore , the aim of this study was to determine whether could *inhibit* [TNF-alpha] activity in chronic wound fluid . Negative_regulation TNF TNFRSF1B 16953659 1646559 Activation of p38 required tumor necrosis factor alpha (TNFalpha) in the nervous system because IT ( a [TNF] *inhibitor* ) given during adjuvant arthritis blocked spinal p38 phosphorylation and reduced clinical signs of adjuvant arthritis . Negative_regulation TNF TNFRSF1B 17510296 1761919 We report ablated , soluble TNF-alpha , TNFRI , and production by neutrophils and macrophages stimulated with various microbial antigens and greatly *reduced* [TNF-alpha] levels in vivo following inflammation induction . Negative_regulation TNF TNFRSF1B 17516123 1772886 We also observed a significant increase in the protein and mRNA levels of proinflammatory cytokines in both serum and cochleae of cisplatin injected rats , which was suppressed by intraperitoneal injection of , an *inhibitor* of [TNF-alpha] . Negative_regulation TNF TNFRSF1B 17724436 1903069 In this study , we investigate the effects of ( 10 mg/kg , s.c. ) , a specific [TNF-alpha-soluble] *inhibitor* , on the acute phase and late mortality in a murine model of MODS of nonseptic origin induced by zymosan ( 500 mg/kg , suspended in saline solution , i.p. ) . Negative_regulation TNF TNFRSF1B 17726611 1801646 The purpose of this study was to determine the effect of , a [TNF-alpha] *inhibitor* , on insulin secretion and insulin sensitivity in psoriatic patients with high risk factors to develop type 2 diabetes mellitus . Negative_regulation TNF TNFRSF1B 17785864 1790837 3 ) blocking or down regulating on activated T cells *inhibits* [TNF-alpha] production , indicating that mTNF on the monocyte surface mediates signaling ; Negative_regulation TNF TNFRSF1B 18186919 1870136 Toward such manipulation in Alzheimer 's disease , a six-month study was conducted with 15 probable-Alzheimer patients who were treated weekly with perispinal injection of , an FDA approved [TNF] *inhibitor* that is now widely used for treatment of rheumatoid arthritis and other systemic diseases associated with inflammation . Negative_regulation TNF TNFRSF1B 18303453 1873584 Effect of , a [tumor necrosis factor-alpha] *inhibitor* , on neuropathic pain in the rat chronic constriction injury model . Negative_regulation TNF TNFRSF1B 18525426 1923110 We describe a patient with severe painful and ataxic sensory neuronopathy in association with systemic lupus erythematosus , who showed marked and sustained improvement on , a [tumor necrosis factor] alpha *inhibitor* , despite a chronic and progressive course that was refractory to several immunomodulatory interventions . Negative_regulation TNF TNFRSF1B 18644112 1947732 Recent clinical studies point to rapid and sustained clinical , cognitive , and behavioral improvement in both Alzheimer 's disease and primary progressive aphasia following weekly perispinal administration of , a [TNF-alpha] *inhibitor* that acts by blocking the binding of this cytokine to its receptors . Negative_regulation TNF TNFRSF1B 18664626 1967278 We studied the [tumor necrosis factor-alpha] *inhibitor* , , combined with corticosteroids in treating 15 patients ( median age , 18 years ; range , 1-60 years ) with IPS . Negative_regulation TNF TNFRSF1B 18753057 1956369 To evaluate the efficacy and safety of , a [tumor necrosis factor (TNF)-alpha] *inhibitor* , in the treatment of ankylosing spondylitis (AS) , and investigate its effect on serum levels of matrix metalloproteinase-3 (MMP-3) . Negative_regulation TNF TNFRSF1B 18824950 1976688 Direct application of the [TNF-alpha] *inhibitor* , , does not affect CGRP expression and phenotypic change of DRG neurons following application of nucleus pulposus onto injured sciatic nerves in rats . Negative_regulation TNF TNFRSF1B 18824950 1976689 The purpose of the current study was to examine the change in behavior and phenotypic change of CGRP-immunoreactive DRG neurons by the [TNF-alpha] *inhibitor* , , in a disc herniation model . Negative_regulation TNF TNFRSF1B 19041607 1998784 Based on this finding , patients with new onset GVHD were treated with steroids plus the [TNF-alpha] *inhibitor* , , on a previously reported pilot trial ( n=20 ) and a phase 2 trial ( n=41 ) and their outcomes were compared with those of contemporaneous patients with GVHD ( n=99 ) whose initial therapy was steroids alone . Negative_regulation TNF TNFRSF1B 19202167 2093532 Tumour necrosis alpha has been implicated in the pathogenesis of autoimmune disorders was to evaluate the safety , tolerability and potential efficacy of the [tumour necrosis factor alpha (TNF-alpha)] *inhibitor* , , in patients with idiopathic membranous nephropathy ( MN ) . Negative_regulation TNF TNFRSF1B 19309569 2052373 The primary aim of this study is to investigate whether the Body Mass Index ( BMI ) of patients influences the clinical response to , a competitive *inhibitor* of [TNF-alpha] approved for the treatment of moderate-to-severe plaque-type psoriasis . Negative_regulation TNF TNFRSF1B 19412129 2106587 Aged rats ( 12 months ) were ovariectomized ( to model a menopausal phenotype ) and treated with placebo , estrogen or [TNF] *inhibitor* ( ) for 4 weeks . Negative_regulation TNF TNFRSF1B 19493331 2098045 Following a vertebral biopsy which failed to detect an infectious organism , the patient was treated with , a [tumor necrosis factor (TNF)-alpha] *inhibitor* , for suspected undifferentiated spondyloarthritis . Negative_regulation TNF TNFRSF1B 20195684 2293695 Since the discovery of the role of tumor necrosis factor (TNF) alpha in the pathogenesis of the disease , three [TNF] *inhibitors* , infliximab , and adalimumab , have become widely used for the treatment of RA . Negative_regulation TNF TNFRSF1B 20430306 2247459 Today , 3 [TNF] *inhibitors* , infliximab , adalimumab , and , have been approved for the treatment of psoriasis arthritis , psoriasis , and other indications like Crohn 's disease , depending on the distinct substance by the European Medicines Agency . Negative_regulation TNF TNFRSF1B 20599469 2339888 A 26-year old woman with a history of psoriasic arthritis treated with [TNF] a *inhibitor* ( ) presented with a biopsy proved class IV lupus nephritis . Negative_regulation TNF TNFRSF1B 21057386 2376437 Direct application of the [tumor necrosis factor-a] *inhibitor* , , into a punctured intervertebral disc decreases calcitonin gene related peptide expression in rat dorsal root ganglion neurons . Negative_regulation TNF TNFRSF1B 21057386 2376438 retrograde neurotracing and immunohistochemistry were used to investigate the effect of the [tumor necrosis factor (TNF)-a] *inhibitor* , , on calcitonin gene related peptide (CGRP) expression in dorsal root ganglion (DRG) neurons innervating intervertebral discs in rats . Negative_regulation TNF TNFRSF1B 21104419 2430998 Systemic and spinal administration of , a [tumor necrosis factor] alpha *inhibitor* , blocks tactile allodynia in diabetic mice . Negative_regulation TNF TNFRSF1B 21188454 2437507 Reduction in serum levels of substance P in patients with rheumatoid arthritis by , a [tumor necrosis factor] *inhibitor* . Negative_regulation TNF TNFRSF1B 21435242 2494016 Moreover , a [tumor necrosis factor] *inhibitor* , , significantly ( P < 0.0001 ) decreased levels of sIL-18Ra in the sera of 29 RA patients 6 months after treatment . Negative_regulation TNF TNFRSF1B 21490086 2444159 We examined the effect of , a [tumor necrosis factor-a] *inhibitor* on morphine tolerance in rats . Negative_regulation TNF TNFRSF1B 21494547 2418109 The increase in PAI-1 was similar in wild-type and IL-6 ( -/- ) mice but was absent in mice treated with , a [TNF-a] *inhibitor* . Negative_regulation TNF TNFRSF1B 21504126 2361639 We also review recent anecdotal data with the [TNF-a] *inhibitor* , , and discuss possible explanations for the failure of preclinical data to translate into successful clinical trials . Negative_regulation TNF TNFRSF1B 21505354 2422980 To test the role of TNF-a in mediating change in the RUPP rat heart , a [TNF-a] *inhibitor* , , was administered on day 18 of gestation at a dose of 0.8 mg/kg , s.c . Negative_regulation TNF TNFRSF1B 21628943 2437006 We report a case of rheumatoid arthritis ( RA ) with autoimmune hepatitis ( AIH ) and Sjogren syndrome ( SjS ) that was treated with the [tumor necrosis factor (TNF)] *inhibitor* , . Negative_regulation TNF TNFRSF1B 21672203 2455357 The [anti-TNF] *inhibitor* , is administered as a once or twice weekly subcutaneous injection for the treatment of rheumatoid arthritis , psoriasis , ankylosing spondylitis , psoriatic arthritis and juvenile idiopathic arthritis ( JIA ) . Negative_regulation TNF TNFRSF1B 22020607 2567877 Epidural administration of spinal nerves with the [tumor necrosis factor-alpha] *inhibitor* , , compared with dexamethasone for treatment of sciatica in patients with lumbar spinal stenosis : a prospective randomized study . Negative_regulation TNF TNFRSF1B 22802951 2628706 Despite persistent elevation of IOP , *reduced* microglial activation , [TNF-a] levels , axon degeneration in the optic nerve , and the loss of RGCs . Negative_regulation TNF TNFRSF1B 22836148 2671072 In fact , intracerebroventricular ( icv ) administration of , an *inhibitor* of [TNF-a] signaling , resulted in anxiolytic-like effects in EAE-mice . Negative_regulation TNF TNFRSF1B 22956307 2726589 could *block* [TNF-a] receptors to restore PPAR-d and improve renal function in mice with hepatic steatosis . Negative_regulation TNF TNFRSF1B 23043728 2726915 The inhibitor of inducible NOS , aminoguanidine , the COX-2 inhibitor , meloxicam , and the competitive *inhibitor* of [TNF-a] , , were used alone or combined to inhibit NO , PGs and TNF-a production respectively , to prevent Stx2 induced preterm delivery . Negative_regulation TNF TNFRSF1B 23043728 2726919 *blocked* the [TNF-a] increase after Stx2 treatment and reduced the preterm delivery by approximately 30 % . Negative_regulation TNF TNFRSF1B 23100196 2703707 Previous experimental data suggest that , a selective [TNF] *inhibitor* , has the ability to ameliorate microglial activation and modulate the adverse synaptic effects of excess TNF . Negative_regulation TNF TNFRSF1B 23769689 2820215 The aim of the present study was to investigate the effects of chronic , a [TNF-a] *inhibitor* , on anxiety- and depression-like neurobehaviors in rats . Negative_regulation TNF TNFRSF1B 24366082 2911484 Treatment of OVX SLE mice with the [tumor necrosis factor] a *inhibitor* , , blunted the OVX induced increase in blood pressure ( 140±2 ) and prevalence of albuminuria ( 22 % ) . Negative_regulation TNF TNFRSF1B 24653517 2718657 Serum [tumor necrosis factor-a] levels , a biomarker for both etanercept 's mechanism of action and treatment efficacy , was *inhibited* by throughout the study , but cyclosporin only showed an inhibitory effect at 48 hours postirradiation . Negative_regulation TNF TNFRSF6B 17393415 1728001 is mostly expressed in tumor cells , and it competitively *inhibits* binding of [TNF] to TNFRs . Negative_regulation TNF TNFSF10 10657659 664130 However , coadministrating .1 and 3C10 *inhibited* the [TNF] response by 80 % . Negative_regulation TNF TNFSF11 16402377 1513161 Since both and CpG-ODN-TLR9 interactions *result* in NF-kappaB activation , p38 and ERK phosphorylation , and [TNF-alpha] synthesis ( all implicated in osteoclastogenesis ) , we hypothesized that CpG-ODN ( but not RANKL ) in addition induces the synthesis of an anti-osteoclastogenic factor . Negative_regulation TNF TNFSF11 16702601 1589855 induced osteoclastogenesis in these monocytic cells , and CLA *inhibited* RANKL induced [tumor necrosis factor-alpha] production and osteoclast differentiation , including osteoclast-specific genes such as tartrate-resistant acid phosphatase , cathepsin K , calcitonin receptor , and matrix metalloproteinase-9 expression and osteoclast-specific transcription factors such as c-Fos , nuclear factor of activated T-cells expression , and bone resorption pit formation . Negative_regulation TNF TNFSF11 18509698 1971902 NO and [tumor necrosis factor (TNF)-alpha] were also suppressed in the *presence* of during osteoclastogenesis by the polyphenols . Negative_regulation TNF TNFSF11 23760678 2854148 [Ad-TNF-a-siRNA] effectively suppressed osteoclast differentiation and bone resorption following exposure to titanium particles in the *presence* of . Negative_regulation TNF TOLLIP 22778396 2639724 Using short hairpin RNA knockdown of TOLLIP in peripheral blood human monocytes , we found that *suppresses* [TNF] and IL-6 production after stimulation with TLR2 and TLR4 ligands . Negative_regulation TNF TP53 11132130 760211 This implies that directly or indirectly *represses* [TNFalpha] gene expression and that modification of p53 mRNA stability or phosphorylation of p53 protein after UV may be responsible for TNFalpha induction in the membrane . Negative_regulation TNF TP53 15811878 1410657 We first observed striking similarities in global gene expression profiles in human prostate cancer cells LNCaP transduced with p53 inhibitory genetic element or treated with TNF , suggesting that *inhibits* transcription of [TNF-inducible] genes that are largely regulated by NFkappaB . Negative_regulation TNF TP53 18753141 1980026 These results demonstrate that S100A6 is *induced* by [tumor necrosis factor-alpha] via an NF-kappaB dependent mechanism , serving a role in homeostasis to limit tumor necrosis factor-alpha induced apoptosis by regulating phosphorylation . Negative_regulation TNF TPH1 24337018 2895111 PCPA markedly attenuated MCT induced pulmonary vascular remodeling and lung inflammation , *inhibited* the expression of and SERT and suppressed the expression of MMP-2/-9 , TIMP-1/-2 , interleukin-1ß (IL-1ß) , [tumor necrosis factor-a (TNF-a)] and intercellular adhesion molecule-1 ( ICAM-1 ) . Negative_regulation TNF TPP1 20693065 290087 *led* to a concentration dependent suppression of macrophage [TNF] activity as well as NK activity of spleen cells . Negative_regulation TNF TPP2 20693065 290086 *led* to a concentration dependent suppression of macrophage [TNF] activity as well as NK activity of spleen cells . Negative_regulation TNF TRAF6 17055451 1636505 While TNF-alpha exerts various biological effects including cell death , the *role* of in the [TNF-alpha] signaling remains to be unclear . Negative_regulation TNF TRIM26 7544757 318392 In contrast , significantly *suppressed* PMA induced [TNF-alpha] and IL-1 beta production by U937 cells in a time and dose dependent fashion . Negative_regulation TNF TRIM26 7544757 318394 Furthermore , Northern blot analysis showed that *suppressed* PMA mediated [TNF-alpha] and IL-1 beta messenger RNA ( mRNA ) expression . Negative_regulation TNF TROVE2 10954049 724509 Production of [tumor necrosis factor (TNF)-alpha] and IL-1beta by mouse mesangial cells was not *blocked* by but production of IL-4 by these cells was inhibited by it ( > 0.1 mM ) . Negative_regulation TNF TSLP 21148792 2396228 In this study , we found that [TNF-a] upregulates the TSLP mRNA and *induces* high levels of protein release in primary human ASM cells . Negative_regulation TNF TSN 21232147 2386715 also enhanced Akt and GSK-3ß phosphorylation and inhibited NF-?B phosphorylation , *resulting* in decreased [TNF-a] , IL-6 and MPO activities . Negative_regulation TNF TTC1 9972134 560137 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC1 9972134 560167 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC12 9972134 560146 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC12 9972134 560176 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC13 9972134 560157 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC13 9972134 560187 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC14 9972134 560147 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC14 9972134 560177 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC16 9972134 560158 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC16 9972134 560188 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC17 9972134 560150 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC17 9972134 560180 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC18 9972134 560162 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC18 9972134 560192 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC19 9972134 560154 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC19 9972134 560184 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC22 9972134 560155 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC22 9972134 560185 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC23 9972134 560151 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC23 9972134 560181 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC24 9972134 560163 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC24 9972134 560193 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC25 9972134 560149 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC25 9972134 560179 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC26 9972134 560144 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC26 9972134 560174 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC27 9972134 560153 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC27 9972134 560183 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC28 9972134 560159 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC28 9972134 560189 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC29 9972134 560160 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC29 9972134 560190 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC3 9972134 560138 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC3 9972134 560168 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC31 9972134 560152 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC31 9972134 560182 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC32 9972134 560164 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC32 9972134 560194 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC33 9972134 560161 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC33 9972134 560191 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC34 9972134 560166 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC34 9972134 560196 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC36 9972134 560165 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC36 9972134 560195 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC37 16141526 1451024 *inhibited* significantly [TNF-alpha] release ( IC50 = 97.6+/-17.8 microg/ml ) and NO production ( IC50 = 280+/-17.8 microg/ml ) . Negative_regulation TNF TTC37 9972134 560145 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC37 9972134 560175 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC38 9972134 560156 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC38 9972134 560186 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC4 9972134 560139 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC4 9972134 560169 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC40 9972134 560148 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC40 9972134 560178 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC5 9972134 560140 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC5 9972134 560170 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC6 9972134 560141 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC6 9972134 560171 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC8 9972134 560142 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC8 9972134 560172 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TTC9 9972134 560143 *inhibited* the secretion of nitric oxide ( NO ) and [TNF alpha] from LPS stimulated macrophages and inhibited macrophage induced thymocyte proliferation . Negative_regulation TNF TTC9 9972134 560173 TTC inhibition of LPS induced NO secretion was not reversed by the addition of recombinant TNF alpha , and *inhibition* of LPS induced [TNF alpha] secretion was not reversed by the addition of NO donor . Negative_regulation TNF TXN 11232604 764029 *inhibits* [tumor necrosis factor-] or interleukin-1 induced NF-kappaB activation at a level upstream of NF-kappaB inducing kinase . Negative_regulation TNF TXN 15696199 1382714 In cultured ECs , reduction of TXNIP expression by small interfering RNA increased binding to ASK1 and *inhibited* [TNF] activation of JNK/p38 and VCAM1 expression . Negative_regulation TNF TYR 19000188 1990880 Coccoloba uvifera L. showed antioxidant and activities and also *inhibited* the production of IL-1alpha , [TNF-alpha] and alpha-MSH in melanocytes subjected to UV radiation ( P < 0.01 ) . Negative_regulation TNF TYRO3 20043264 2192887 In addition , *inhibited* IR-induced [TNFalpha] , IL-1alpha , and MnSOD levels and MnSOD activity . Negative_regulation TNF TYRP1 21078543 2371601 In addition , *inhibited* production of the cytokines [TNF-a] and IL-12 in LPS stimulated DCs . Negative_regulation TNF UBB 23844119 2816563 Ectopic expression of ( +1 ) *suppressed* [TNF-a-] and IL-1ß induced activation of NF-?B and JNK signaling pathway . Negative_regulation TNF UCN 17117478 1677403 We have found that : ( a ) CRF , and UCN2 transiently *suppressed* the release of [Tumor Necrosis Factor-alpha (TNF-alpha)] in LPS activated macrophages , an effect peaking at 4 h . Negative_regulation TNF UCN 9814993 546464 In mice , ( 1 microg/mouse sc ) significantly *reduced* lipopolysaccharide (LPS) induced serum [tumor necrosis factor (TNF)] and interleukin (IL)-1beta levels in vivo but did not affect serum IL-6 . Negative_regulation TNF UCN2 17117478 1677404 We have found that : ( a ) CRF , Urocortin (UCN)1 and transiently *suppressed* the release of [Tumor Necrosis Factor-alpha (TNF-alpha)] in LPS activated macrophages , an effect peaking at 4 h . Negative_regulation TNF UGCG 10805216 691949 IFN-gamma as well as the , Dexamethasone and Budesonide , *inhibited* [TNF-alpha] induced IL-8 secretion in a dose dependent manner . Negative_regulation TNF UGCG 11029361 739835 Instilled 1 h before LPS , both *reduced* [TNF-alpha] by 70 % ( p < 0.05 ) and mononuclear cells by 55 % ( p < 0.01 ) , with no reduction in neutrophils . Negative_regulation TNF UGCG 12689663 1078889 At the same time , *inhibited* mRNA expression of G ( i , ) and [TNF-alpha] of synoviocytes and increased mRNA expression of G ( s ) of synoviocytes in CIA rats . Negative_regulation TNF UGCG 15265778 1275490 Evidence accumulated over the last 5-10 years indicates that *inhibit* the production of interleukin (IL)-12 , interferon (IFN)-gamma , IFN-alpha , and [tumor necrosis factor (TNF)-alpha] by antigen presenting cells (APCs) and T helper (Th)1 cells , but upregulate the production of IL-4 , IL-10 , and IL-13 by Th2 cells . Negative_regulation TNF UMOD 23108005 2717365 In the presence of , mRNA expression of IL-6 and [TNF-a] and IL-6 and NO serum levels were *reduced* and smooth muscle function was improved . Negative_regulation TNF UMOD 2681538 121075 The conditioned medium , on the other hand , *suppressed* [tumor necrosis factor (TNF)] activity detected in the MT-2 culture . Negative_regulation TNF UTP15 10788429 688556 In the EAhy926 endothelial cell line , , ATP , and forskolin , but not UDP and epidermal growth factor , *inhibited* [tumor necrosis factor alpha (TNFalpha)-] and sorbitol stimulation of the stress activated protein kinases , JNK , and p38 mitogen activated protein (MAP) kinase , and MAPKAP kinase-2 , the downstream target of p38 MAP kinase . Negative_regulation TNF UTP18 10788429 688554 In the EAhy926 endothelial cell line , , ATP , and forskolin , but not UDP and epidermal growth factor , *inhibited* [tumor necrosis factor alpha (TNFalpha)-] and sorbitol stimulation of the stress activated protein kinases , JNK , and p38 mitogen activated protein (MAP) kinase , and MAPKAP kinase-2 , the downstream target of p38 MAP kinase . Negative_regulation TNF UTP20 10788429 688552 In the EAhy926 endothelial cell line , , ATP , and forskolin , but not UDP and epidermal growth factor , *inhibited* [tumor necrosis factor alpha (TNFalpha)-] and sorbitol stimulation of the stress activated protein kinases , JNK , and p38 mitogen activated protein (MAP) kinase , and MAPKAP kinase-2 , the downstream target of p38 MAP kinase . Negative_regulation TNF UTP23 10788429 688557 In the EAhy926 endothelial cell line , , ATP , and forskolin , but not UDP and epidermal growth factor , *inhibited* [tumor necrosis factor alpha (TNFalpha)-] and sorbitol stimulation of the stress activated protein kinases , JNK , and p38 mitogen activated protein (MAP) kinase , and MAPKAP kinase-2 , the downstream target of p38 MAP kinase . Negative_regulation TNF UTP3 10788429 688555 In the EAhy926 endothelial cell line , , ATP , and forskolin , but not UDP and epidermal growth factor , *inhibited* [tumor necrosis factor alpha (TNFalpha)-] and sorbitol stimulation of the stress activated protein kinases , JNK , and p38 mitogen activated protein (MAP) kinase , and MAPKAP kinase-2 , the downstream target of p38 MAP kinase . Negative_regulation TNF UTP6 10788429 688553 In the EAhy926 endothelial cell line , , ATP , and forskolin , but not UDP and epidermal growth factor , *inhibited* [tumor necrosis factor alpha (TNFalpha)-] and sorbitol stimulation of the stress activated protein kinases , JNK , and p38 mitogen activated protein (MAP) kinase , and MAPKAP kinase-2 , the downstream target of p38 MAP kinase . Negative_regulation TNF UTRN 21453958 2432618 Reduction of Drp1 activity by mitochondrial division inhibitor and decrease of expression using small interfering RNA *inhibit* mitochondrial translocation , degranulation , and [TNF] secretion . Negative_regulation TNF VCAM1 11888521 920049 Inhibition of [TNF-alpha] *induced* ICAM-1 , and E-selectin expression by selenium . Negative_regulation TNF VCAM1 17956026 1814776 Furthermore , [TNF-alpha] and IL-4 , when added together , *induced* a synergistic effect on the secretion of and eotaxin . Negative_regulation TNF VCAM1 8547644 346411 We have previously shown that VCAM-1 expression is *induced* on human umbilical vein EC ( HUVEC ) by both [tumor necrosis factor alpha (TNF-alpha)] and interleukin-1 alpha (IL-1 alpha) , whereas on human dermal microvascular EC ( HDMEC ) only TNF alpha results in expression . Negative_regulation TNF VCP 20100830 2219264 Transient expression of either or PP2Ac was *sufficient* to elevate levels of the dual specificity phosphatase DUSP1 , reduce p38 MAPK activation , and suppress [tumor necrosis factor-alpha] release . Negative_regulation TNF VDR 9723887 529270 Here we test the hypothesis that [TNF] *induces* a nuclear inhibitor of binding to DNA and that this inhibitor can have independent effects on RXR . Negative_regulation TNF VDR 9723887 529273 To determine if [TNF-alpha] *induced* a nuclear inhibitor of and RXR binding to DNA , nuclear extract was isolated from TNF treated receptor deficient COS cells and mixed with nuclear extract from ligand treated receptor replete COS cells . Negative_regulation TNF VEGFA 11280761 798767 However , although [TNF-alpha] induced rapid activation of IkappaB kinase (IKK) as expected , this activity was substantially *reduced* in the presence of . Negative_regulation TNF VEGFA 12811578 1113563 Comparative effects of polyphenols from green tea ( EGCG ) and soybean ( genistein ) on and IL-8 release from normal human keratinocytes *stimulated* with the proinflammatory cytokine [TNFalpha] . Negative_regulation TNF VEGFA 15448463 1300590 Both IL-1alpha and [TNF-alpha] *induced* significantly high levels of mRNA gene expression in human pulp and gingival fibroblasts ( p < 0.05 ) . Negative_regulation TNF VEGFA 16039554 1437619 The effect of ESM on [TNF-alpha] induced endothelial permeability and redistribution of VE-cadherin is likely *due* to a reduction of protein expression as a result of modulation of the ERK signaling pathway . Negative_regulation TNF VEGFA 16635740 1552733 On the protein level , melanin significantly induced [TNF-alpha] and IL-6 protein production and *inhibited* production by monocytes and PBMC . Negative_regulation TNF VEGFA 20357262 2244978 Stimulation of macrophages with group X sPLA ( 2 ) in the presence of adenosine analogs induced a synergistic increase of release and *inhibited* [TNF-alpha] production through a cooperation between A ( 2A ) and A ( 3 ) receptors . Negative_regulation TNF VIMP 16227999 1469942 Furthermore , suppression of by short interfering RNA in macrophage cells *increased* the release of IL-6 and [TNF-alpha] . Negative_regulation TNF VIP 10496178 647164 We reported previously that and PACAP *inhibit* IL-6 , IL-12 , [TNF alpha] and NO production , and enhance IL-10 production , from lipopolysaccharide (LPS) stimulated macrophages . Negative_regulation TNF VIP 10496178 647168 The *inhibition* of [TNF alpha] and NO occurs through both CD14 dependent and -independent mechanisms , whereas the inhibition of IL-6 production appears to be strictly CD14 dependent . Negative_regulation TNF VIP 10542221 563762 We showed previously that and PACAP *inhibit* the production of macrophage derived [tumor necrosis factor-alpha] , interleukin (IL)-6 , nitric oxide , and IL-12 . Negative_regulation TNF VIP 10804204 691923 [TNF-alpha] protein levels were *reduced* 90 % by or PACAP at 10 ( -7 ) m . Negative_regulation TNF VIP 10804204 691926 We conclude that and PACAP *inhibit* the production of [TNF-alpha] from activated microglia by a cAMP dependent pathway . Negative_regulation TNF VIP 12525573 1048049 and PACAP *inhibit* [TNF-alpha] , IL-1beta , IL-6 , and NO production by lipopolysaccharide (LPS) activated microglia . Negative_regulation TNF VIP 14680506 1179090 partially *suppressed* monocyte- and macrophage derived [tumour necrosis factor alpha (TNF-alpha)] with no effect on IL-10 , whereas VIP fails to regulate IL-10 and TNF-alpha production by T lymphocytes . Negative_regulation TNF VIP 15812889 1392325 The in culture supernatant potently *inhibited* [TNF-alpha] production by LPS induced Macrophages in vitro . Negative_regulation TNF VIP 16246930 1471543 ( 10 ( -8 ) M ) significantly ( P < 0.05 ) *inhibits* [TNF-alpha] production by human monocytic THP1 cells stimulated with Pg LPS . Negative_regulation TNF VIP 19222997 2050268 Meanwhile , significantly *inhibited* the release of inflammatory cytokines such as [tumor necrosis factor-alpha (TNF-alpha)] and interferon-gamma (IFN-gamma) in concanavalin A-injected mice , but markedly elevated the production of anti-inflammatory cytokine interleukine-10 (IL-10) . Negative_regulation TNF VIP 23744729 2838510 In vitro , not only *diminished* macrophage [tumor necrosis factor] a/IL-6/IL-12 expression in a PKA dependent manner but also prevented necrosis/apoptosis in primary mouse hepatocyte cultures . Negative_regulation TNF VIP 8982099 403812 On the contrary , GRP and *inhibited* highly the LPS induced [TNF alpha] production in young controls . Negative_regulation TNF VIP 9726844 529838 In vitro studies show that at physiologic concentrations , *inhibited* IL-12 and NO but not [TNF alpha] production in macrophages which were stimulated with LPS or superantigens . Negative_regulation TNF VIP 9813054 546157 Both and PACAP *inhibit* [TNFalpha] production from lipopolysaccharide stimulated RAW 246.7 cells in a dose- and time dependent manner . Negative_regulation TNF VIP 9916753 587542 *reduce* serum and peritoneal [TNF-alpha] and IL-6 , suggesting that the protective effect is exerted by inhibiting the production of endogenous TNF-alpha/IL-6 . Negative_regulation TNF VIP 9973433 596157 Previous reports showed that *inhibit* IL-6 and [TNF-alpha] production in LPS stimulated macrophages . Negative_regulation TNF WAS 1334476 205876 Thus , our data provide evidence that can *inhibit* [TNF] production by mouse and human macrophages . Negative_regulation TNF WAS 23810685 2834470 In the lipopolysaccharide (LPS) induced systemic inflammation model , significantly *inhibited* serum [tumor necrosis factor-alpha] ( TNF-a ) release in mice . Negative_regulation TNF WAS 23810685 2834471 Our data demonstrated that significantly *inhibited* LPS induced [TNF-a] , interleukin-6(IL-6) and nitric oxide ( NO ) production . Negative_regulation TNF WAS 23810685 2834473 *inhibited* the production of [TNF-a] and IL-6 by down regulating LPS induced IL-6 and TNF-a mRNA expression . Negative_regulation TNF WAS 8118892 246616 We find that these low levels of *inhibit* [tumor necrosis factor-alpha (TNF)] induction from LGL by C. albicans and are dependent upon THC dose ( 0.005-5.0 micrograms/ml ) and length of exposure ( 0.05-3.0 hr ) . Negative_regulation TNF WAS 8732433 374079 However , did not *inhibit* the levels of LPS induced TNF-alpha mRNA and intracellular [TNF-alpha] precursor protein , had only a weak effect on expression of membrane bound TNF-alpha , but suppressed TNF-alpha maturation/secretion by macrophages . Negative_regulation TNF WAS 9666273 518551 It was found that *suppressed* IL-12 , IL-15 and IL-6 and increased IL-1 alpha , IL-1 beta , and [TNF alpha] in all of the stimulated cultures . Negative_regulation TNF WAS 9718090 528146 WIN 55,212-2 and *induced* a concentration dependent decrease in [TNF-alpha] level in the bronchoalveolar lavage fluid ( BALF ) ( maximum inhibition 52.7 % and 36.9 % for intranasal doses of 750 nmol x kg ( -1 ) and 2.65 mmol x kg ( -1 ) , respectively ) . Negative_regulation TNF WDR61 16141526 1451025 *inhibited* significantly [TNF-alpha] release ( IC50 = 97.6+/-17.8 microg/ml ) and NO production ( IC50 = 280+/-17.8 microg/ml ) . Negative_regulation TNF WDR61 1873355 165233 Further , the *role* of released in response to a challenge with LPS in the regulation of [TNF] and IL-6 production was investigated . Negative_regulation TNF WDR61 8514698 221948 Repeated dosing also *resulted* in sustained increased serum [tumor necrosis factor-alpha] levels ( 1,610 +/- 470 pg/ml , P < 0.01 ) and further exacerbation of the leukopenia ( -68 +/- 6 % , P < 0.01 ) and thrombocytopenia ( -65 +/- 8 % , P < 0.01 ) . Negative_regulation TNF WDR61 9403541 469606 Furthermore , inhibiting production with AACOCF3 , or manoalide , also *inhibited* LPS induced Mphi [TNF] mRNA expression . Negative_regulation TNF WNK1 15980040 1465290 Overexpression of dominant negative *reduced* TNF-alpha production 3.5-fold , whereas overexpression of dominant negative IKK-beta reduced LPS induced [TNF-alpha] production 2-fold and p65 phosphorylation 2-fold . Negative_regulation TNF WNK1 20231449 2230278 Silymarin suppressed [TNF-alpha] activation of NF-kappaB dependent transcription , which *involved* partial inhibition of IkappaB and serine phosphorylation , and p50 and p65 nuclear translocation , without affecting binding of p50 and p65 to DNA . Negative_regulation TNF WNK1 20564507 2345399 Moreover , HSYA decreased NF-?B nuclear translocation , *inhibited* proinflammatory cytokine [TNF-a] , IL-1ß and IL-6 mRNA expression and promoted antiinflammatory cytokine IL-10 gene expression following LPS injection . Negative_regulation TNF WNK1 23072581 2740411 Moreover , LPS induced increase of cytokine production ( [TNF-a] , IL-1ß ) was *inhibited* by cilostazol , an effect which was accompanied by suppression of I?Ba degradation , and NF-?B nuclear translocation . Negative_regulation TNF WNK1 24330848 2880517 g-Ad apparently *induced* [TNF-a] , IL-8 , and IL-6 production , which was inhibited by PDTC or NAC , and increased intracellular ROS levels and NF-?B p65 activation , whereas f-Ad significantly suppressed production of inflammatory factors and NF-?B activation and also decreased the intracellular ROS levels . Negative_regulation TNF WNT1 22923429 2837599 Studies assessing mechanisms of estrogen action on bone in humans have identified effects of estrogen on RANKL expression by several different cell types in the bone microenvironment , a *role* for [TNF-a] and IL-1ß in mediating effects of estrogen deficiency on bone , and possible regulation of the inhibitor , sclerostin , by estrogen . Negative_regulation TNF WNT11 22923429 2837600 Studies assessing mechanisms of estrogen action on bone in humans have identified effects of estrogen on RANKL expression by several different cell types in the bone microenvironment , a *role* for [TNF-a] and IL-1ß in mediating effects of estrogen deficiency on bone , and possible regulation of the inhibitor , sclerostin , by estrogen . Negative_regulation TNF WNT16 22923429 2837606 Studies assessing mechanisms of estrogen action on bone in humans have identified effects of estrogen on RANKL expression by several different cell types in the bone microenvironment , a *role* for [TNF-a] and IL-1ß in mediating effects of estrogen deficiency on bone , and possible regulation of the inhibitor , sclerostin , by estrogen . Negative_regulation TNF WNT2 22923429 2837601 Studies assessing mechanisms of estrogen action on bone in humans have identified effects of estrogen on RANKL expression by several different cell types in the bone microenvironment , a *role* for [TNF-a] and IL-1ß in mediating effects of estrogen deficiency on bone , and possible regulation of the inhibitor , sclerostin , by estrogen . Negative_regulation TNF WNT3 22923429 2837602 Studies assessing mechanisms of estrogen action on bone in humans have identified effects of estrogen on RANKL expression by several different cell types in the bone microenvironment , a *role* for [TNF-a] and IL-1ß in mediating effects of estrogen deficiency on bone , and possible regulation of the inhibitor , sclerostin , by estrogen . Negative_regulation TNF WNT3A 20667980 2335162 Furthermore , *reduced* [TNF] release , suggesting that Wnt3a promotes anti-inflammatory functions in murine macrophages . Negative_regulation TNF WNT4 22923429 2837603 Studies assessing mechanisms of estrogen action on bone in humans have identified effects of estrogen on RANKL expression by several different cell types in the bone microenvironment , a *role* for [TNF-a] and IL-1ß in mediating effects of estrogen deficiency on bone , and possible regulation of the inhibitor , sclerostin , by estrogen . Negative_regulation TNF WNT6 22923429 2837604 Studies assessing mechanisms of estrogen action on bone in humans have identified effects of estrogen on RANKL expression by several different cell types in the bone microenvironment , a *role* for [TNF-a] and IL-1ß in mediating effects of estrogen deficiency on bone , and possible regulation of the inhibitor , sclerostin , by estrogen . Negative_regulation TNF WNT6 24123681 2863751 Further functional studies in M. tuberculosis infected macrophages using Wnt6 conditioned medium and Wnt6-deficient macrophages uncovered a *dependent* induction of macrophage Arginase-1 and downregulation of [TNF-a] . Negative_regulation TNF WWP1 23799152 2802839 Knocking down enhanced the TNF-a and IL-6 production induced by LPS , and over-expression of WWP1 *inhibited* the [TNF-a] and IL-6 production induced by LPS , but not by TNF-a . Negative_regulation TNF XRCC5 9636658 513378 The *role* of , a protein kinase involved in the response to DNA damage , in the activation of NF kappa B by IR and [TNF alpha] was examined . Negative_regulation TNF XRCC6 9636658 513379 The *role* of , a protein kinase involved in the response to DNA damage , in the activation of NF kappa B by IR and [TNF alpha] was examined . Negative_regulation TNF ZFAND5 14754897 1226422 also *inhibited* [tumor necrosis factor (TNF)-] , interleukin-1- , and Toll-like receptor 4-induced NFkappaB activation in a dose dependent manner . Negative_regulation TNF ZFP36 10763822 683930 The immediate early protein is *required* to prevent inappropriate production of the cytokine [TNF-alpha] , and is a member of a zinc finger protein family that is associated with RNA binding . Negative_regulation TNF ZFP36 14638848 1176700 IL-4-Stat6 signaling induces expression and *inhibits* [TNF-alpha] production in mast cells . Negative_regulation TNF ZFP36 14638848 1176710 Furthermore , IL-4 induced the expression of tristetraprolin (TTP) , an RNA binding protein that promotes decay of ARE containing mRNA , in mast cells by a Stat6 dependent mechanism , and the depletion of expression by RNA interference *prevented* IL-4 induced down-regulation of [TNF-alpha] production in mast cells . Negative_regulation TNF ZFP36 16596264 1544813 Our results indicate that either or TZF gene transduction using retrovirus vectors can *reduce* the production of [TNF-alpha] in Jurkat T cells although some differences were noted between TTP and TZF in cell growth and occurrence of apoptosis . Negative_regulation TNF ZFP36 16982682 1640418 Small interfering RNAs to TTP significantly prevent this effect , and a cell line stably expressing a short-hairpin RNA to TTP conclusively establishes that is *critical* for dexamethasone inhibition of [TNF-alpha] mRNA expression . Negative_regulation TNF ZFP36 17964608 1831041 *increases* the turnover rate of the target mRNAs , thereby reducing , for example , the expression of [TNF-alpha] and GM-CSF . Negative_regulation TNF ZFP36 18469159 1933214 By binding to ARE , *increases* the degradation of TNF-alpha mRNA , thereby reducing the expression of [TNF-alpha] . Negative_regulation TNF ZFP36 21611196 2436181 Conversely , transfection of miR-346 in LPS activated THP-1 cells increased mRNA expression and *inhibited* [TNF-a] release . Negative_regulation TNF ZFP36 8630730 361272 These results indicate a *role* for in regulating [TNF alpha] synthesis , secretion , turnover , or action . Negative_regulation TNF ZNF10 8557994 347715 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF100 8557994 347716 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF101 8557994 347717 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF106 8557994 347718 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF107 8557994 347719 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF112 8557994 347720 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF114 8557994 347721 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF117 8557994 347722 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF12 8557994 347723 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF121 8557994 347724 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF124 8557994 347725 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF131 8557994 347726 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF132 8557994 347727 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF133 8557994 347728 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF134 8557994 347729 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF135 8557994 347730 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF136 8557994 347731 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF138 8557994 347732 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF14 8557994 347733 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF140 8557994 347734 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF141 8557994 347735 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF142 8557994 347736 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF143 8557994 347737 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF146 8557994 347738 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF148 8557994 347739 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF154 8557994 347740 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF155 8557994 347741 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF157 8557994 347742 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF16 8557994 347744 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF160 8557994 347745 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF165 8557994 347746 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF169 8557994 347747 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF17 8557994 347748 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF174 8557994 347749 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF175 8557994 347750 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF177 8557994 347751 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF18 8557994 347752 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF180 8557994 347753 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF181 8557994 347754 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF182 8557994 347768 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF184 8557994 347755 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF185 8557994 347756 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF189 8557994 347757 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF19 8557994 347758 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF195 8557994 347759 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF197 8557994 347760 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF2 8557994 347761 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF20 8557994 347762 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF200 8557994 347763 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF202 8557994 347764 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF205 8557994 347765 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF207 8557994 347766 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF208 8557994 347767 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF211 8557994 347769 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF212 8557994 347770 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF213 8557994 347771 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF214 8557994 347772 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF215 8557994 347773 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF217 8557994 347774 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF219 8557994 347775 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF22 8557994 347776 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF221 8557994 347777 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF222 8557994 347778 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF223 8557994 347779 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF224 8557994 347780 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF225 8557994 347781 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF226 8557994 347782 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF227 8557994 347783 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF229 8557994 347784 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF23 8557994 347785 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF230 8557994 347786 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF232 8557994 347787 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF233 8557994 348151 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF234 8557994 347788 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF235 8557994 347714 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF236 8557994 347789 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF239 8557994 347790 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF24 8557994 347791 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF248 8557994 347792 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF25 8557994 347793 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF250 8557994 347794 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF251 8557994 347795 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF253 8557994 347852 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF254 8557994 347796 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF256 8557994 347797 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF257 8557994 347853 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF259 8557994 347798 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF26 8557994 347799 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF260 8557994 347854 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF263 8557994 347800 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF264 8557994 347801 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF266 8557994 347802 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF267 8557994 347803 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF268 8557994 347804 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF271 8557994 347805 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF273 8557994 347806 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF274 8557994 347807 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF275 8557994 347808 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF276 8557994 347957 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF277 8557994 347809 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF28 8557994 347810 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF281 8557994 347811 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF282 8557994 347812 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF283 8557994 347813 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF284 8557994 347814 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF285 8557994 347815 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF287 8557994 347855 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF292 8557994 347895 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF296 8557994 347873 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF3 8557994 347816 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF30 8557994 347817 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF300 8557994 347818 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF302 8557994 347863 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF304 8557994 347856 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF311 8557994 347862 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF316 8557994 347861 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF317 8557994 347857 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF318 8557994 347858 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF319 8557994 347859 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF32 8557994 347819 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF320 8557994 347860 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF322 8557994 347964 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF324 8557994 347864 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF326 8557994 347865 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF329 8557994 347866 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF330 8557994 347867 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF331 8557994 347868 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF333 8557994 347869 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF334 8557994 347870 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF335 8557994 347871 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF337 8557994 347872 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF34 8557994 347820 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF341 8557994 347874 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF343 8557994 347875 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF345 8557994 347878 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF346 8557994 347879 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF347 8557994 347880 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF35 8557994 347821 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF350 8557994 347881 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF358 8557994 347885 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF362 8557994 347889 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF365 8557994 347891 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF366 8557994 347892 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF367 8557994 347893 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF382 8557994 347886 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF383 8557994 347896 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF384 8557994 347713 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF391 8557994 347898 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF394 8557994 347901 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF395 8557994 347897 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF396 8557994 347900 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF397 8557994 347899 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF398 8557994 347894 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF404 8557994 347902 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF407 8557994 347903 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF408 8557994 347904 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF41 8557994 347822 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF410 8557994 347905 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF414 8557994 347909 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF415 8557994 347910 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF416 8557994 347911 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF417 8557994 347912 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF418 8557994 347913 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF419 8557994 347914 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF420 8557994 347915 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF423 8557994 347884 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF425 8557994 347916 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF426 8557994 347917 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF428 8557994 347918 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF429 8557994 347925 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF43 8557994 347823 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF430 8557994 347920 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF431 8557994 347921 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF432 8557994 347922 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF433 8557994 347923 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF436 8557994 347924 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF438 8557994 347932 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF439 8557994 347926 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF44 8557994 347824 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF440 8557994 347927 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF441 8557994 347928 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF442 8557994 347929 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF443 8557994 347930 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF444 8557994 347876 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF445 8557994 347931 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF446 8557994 347933 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF449 8557994 347934 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF45 8557994 347825 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF451 8557994 347935 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF454 8557994 347936 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF460 8557994 347937 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF461 8557994 347938 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF462 8557994 347939 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF467 8557994 347948 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF468 8557994 348173 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF469 8557994 347950 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF470 8557994 347946 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF471 8557994 347951 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF473 8557994 347952 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF474 8557994 347953 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF479 8557994 347954 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF48 8557994 347826 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF480 8557994 347956 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF483 8557994 347958 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF484 8557994 347959 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF485 8557994 347960 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF486 8557994 347919 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF487 8557994 347961 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF488 8557994 347962 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF490 8557994 347965 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF491 8557994 347966 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF492 8557994 347967 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF493 8557994 347968 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF496 8557994 347969 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF497 8557994 347970 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF500 8557994 347971 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF501 8557994 347972 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF502 8557994 347973 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF503 8557994 347963 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF506 8557994 347974 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF507 8557994 347975 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF510 8557994 348121 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF511 8557994 348095 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF512 8557994 348128 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF513 8557994 348040 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF514 8557994 348014 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF516 8557994 348114 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF517 8557994 348075 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF519 8557994 348145 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF521 8557994 347976 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF524 8557994 348090 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF525 8557994 348134 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF526 8557994 348132 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF527 8557994 348130 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF528 8557994 348129 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF529 8557994 348127 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF530 8557994 348126 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF532 8557994 348149 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF534 8557994 348026 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF536 8557994 348118 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF540 8557994 347996 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF541 8557994 347995 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF542 8557994 348000 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF543 8557994 347993 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF544 8557994 347883 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF546 8557994 348102 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF547 8557994 348034 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF548 8557994 348041 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF549 8557994 348044 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF550 8557994 348099 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF551 8557994 347987 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF552 8557994 348021 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF554 8557994 348043 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF555 8557994 348093 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF556 8557994 348004 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF557 8557994 348098 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF558 8557994 348032 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF559 8557994 348087 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF56 8557994 347827 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF560 8557994 348038 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF561 8557994 348104 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF562 8557994 348018 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF563 8557994 348142 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF564 8557994 348157 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF565 8557994 348048 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF566 8557994 348015 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF567 8557994 348105 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF568 8557994 347999 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF569 8557994 347978 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF57 8557994 347828 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF570 8557994 348029 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF571 8557994 347984 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF572 8557994 348050 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF573 8557994 348030 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF574 8557994 348022 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF575 8557994 348069 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF576 8557994 348092 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF577 8557994 348103 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF578 8557994 348035 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF579 8557994 348045 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF580 8557994 348137 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF581 8557994 347985 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF582 8557994 348031 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF583 8557994 348033 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF584 8557994 348067 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF586 8557994 348017 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF587 8557994 348155 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF589 8557994 347882 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF592 8557994 348113 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF593 8557994 348150 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF594 8557994 348131 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF595 8557994 348061 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF596 8557994 348065 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF597 8557994 348042 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF598 8557994 348084 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF599 8557994 348028 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF600 8557994 348153 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF605 8557994 348082 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF606 8557994 348011 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF607 8557994 348086 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF608 8557994 348123 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF609 8557994 348115 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF610 8557994 348046 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF611 8557994 348109 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF613 8557994 348008 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF614 8557994 347977 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF615 8557994 347979 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF616 8557994 348080 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF618 8557994 348133 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF619 8557994 348055 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF620 8557994 348108 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF621 8557994 347982 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF622 8557994 348156 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF623 8557994 348119 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF624 8557994 348124 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF625 8557994 348144 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF626 8557994 348139 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF627 8557994 348143 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF628 8557994 348079 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF629 8557994 348117 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF630 8557994 348111 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF638 8557994 347888 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF639 8557994 348152 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF641 8557994 348158 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF644 8557994 348122 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF645 8557994 348027 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF646 8557994 348116 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF648 8557994 347890 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF649 8557994 348006 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF652 8557994 348120 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF653 8557994 347991 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF654 8557994 348003 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF655 8557994 348147 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF658 8557994 347992 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF66 8557994 347830 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF660 8557994 348047 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF662 8557994 348159 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF663 8557994 347997 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF664 8557994 348001 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF665 8557994 348013 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF667 8557994 348110 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF668 8557994 348007 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF669 8557994 348005 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF670 8557994 348085 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF671 8557994 348025 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF672 8557994 348023 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF674 8557994 347887 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF675 8557994 348146 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF676 8557994 347907 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF677 8557994 348107 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF678 8557994 348101 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF679 8557994 348100 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF680 8557994 348054 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF681 8557994 348036 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF682 8557994 348112 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF683 8557994 348096 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF684 8557994 348094 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF687 8557994 348125 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF688 8557994 348141 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF689 8557994 347990 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF69 8557994 347831 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF691 8557994 348077 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF692 8557994 348019 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF695 8557994 348154 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF696 8557994 348010 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF697 8557994 348160 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF699 8557994 347980 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF7 8557994 347832 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF70 8557994 347833 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF700 8557994 347994 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF701 8557994 348002 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF703 8557994 348012 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF704 8557994 348162 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF706 8557994 347983 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF707 8557994 348074 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF708 8557994 347743 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF709 8557994 347908 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF71 8557994 347834 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF710 8557994 347998 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF711 8557994 347829 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF713 8557994 347944 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF714 8557994 348059 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF716 8557994 348163 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF717 8557994 348136 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF718 8557994 348052 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF720 8557994 348056 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF721 8557994 348135 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF723 8557994 348161 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF726 8557994 348164 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF727 8557994 347947 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF728 8557994 348165 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF729 8557994 348166 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF73 8557994 347835 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF730 8557994 348171 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF732 8557994 348193 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF735 8557994 348167 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF736 8557994 348168 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF737 8557994 348169 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF738 8557994 348170 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF74 8557994 347836 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF740 8557994 348068 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF746 8557994 347943 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF747 8557994 348091 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF749 8557994 348172 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF750 8557994 348009 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF76 8557994 347837 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF761 8557994 347949 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF763 8557994 348071 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF764 8557994 348088 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF765 8557994 347986 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF766 8557994 348081 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF767 8557994 347942 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF768 8557994 348024 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF77 8557994 347838 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF770 8557994 348020 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF771 8557994 348138 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF772 8557994 348174 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF773 8557994 348140 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF774 8557994 348175 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF775 8557994 348097 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF776 8557994 348051 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF777 8557994 347945 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF778 8557994 348037 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF781 8557994 348049 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF782 8557994 348176 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF783 8557994 348062 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF784 8557994 348177 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF785 8557994 348039 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF786 8557994 347941 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF787 8557994 348058 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF788 8557994 348178 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF789 8557994 348073 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF79 8557994 347839 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF790 8557994 348179 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF791 8557994 348053 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF792 8557994 347981 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF793 8557994 348180 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF799 8557994 348083 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF8 8557994 347840 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF80 8557994 347841 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF800 8557994 348064 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF805 8557994 347955 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF806 8557994 348181 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF807 8557994 348182 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF808 8557994 348183 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF81 8557994 347842 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF812 8557994 348184 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF813 8557994 348185 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF814 8557994 348186 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF816 8557994 348057 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF821 8557994 348078 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF823 8557994 348148 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF827 8557994 348060 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF829 8557994 348187 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF83 8557994 347843 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF830 8557994 348089 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF831 8557994 347877 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF835 8557994 348188 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF836 8557994 348189 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF837 8557994 347989 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF839 8557994 347906 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF84 8557994 347844 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF840 8557994 348190 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF841 8557994 348070 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF843 8557994 348106 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF844 8557994 348016 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF845 8557994 347988 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF846 8557994 348063 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF85 8557994 347845 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF850 8557994 348076 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF852 8557994 348072 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF853 8557994 347940 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF860 8557994 348191 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF862 8557994 348192 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF865 8557994 348198 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF878 8557994 348194 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF879 8557994 348196 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF880 8557994 348195 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF883 8557994 348066 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF888 8557994 348197 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF891 8557994 348199 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF90 8557994 347846 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF91 8557994 347847 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF92 8557994 347848 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF93 8557994 347849 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF98 8557994 347850 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNF ZNF99 8557994 347851 A20 *inhibits* [TNF] and IL-1 signaling . Negative_regulation TNFAIP6 TNF 11943733 928747 Paradoxically , *reduced* [TSG-6] promoter activity by 50 % . Negative_regulation TNFRSF10A CCND1 21209944 2359463 In xenografted tumors , resveratrol upregulated the expressions of [TRAIL-R1/DR4] , TRAIL-R2/DR5 , Bax and p27 ( /KIP1 ) , and *inhibited* the expression of Bcl-2 and . Negative_regulation TNFRSF10B CCND1 21209944 2359465 In xenografted tumors , resveratrol upregulated the expressions of TRAIL-R1/DR4 , [TRAIL-R2/DR5] , Bax and p27 ( /KIP1 ) , and *inhibited* the expression of Bcl-2 and . Negative_regulation TNFRSF10B CTGF 21800344 2509942 Importantly , *down-regulated* tumor necrosis factor related apoptosis inducing ligand ( [TRAIL) receptor 2] expression and was involved in the reduced sensitivity of these cells toward TRAIL mediated apoptosis . Negative_regulation TNFRSF10B TNFSF10 17476690 1772256 Although Zap-70 ( high ) and Zap-70 ( low ) B-CLL samples displayed similar levels of surface death receptor [TRAIL-R2] , recombinant *induced* cytotoxicity only in a subset of Zap-70 ( low ) B-CLL samples while Zap-70 ( high ) were completely resistant to TRAIL . Negative_regulation TNFRSF10D TNFSF10 15385934 1324164 *induced* no discernible changes in FLIP , DR4 , DR5 , Mcl-1 , or survivin expression , modest declines in levels of [DcR2] and c-IAP , but resulted in the marked transcriptional downregulation of XIAP . Negative_regulation TNFRSF11B IL1B 19406240 2095647 In PC-3 cells , stimulated IL-6 and OPG release , and dexamethasone dose-dependently *inhibited* IL-1beta-inducible IL-6 release , and constitutive and IL-1beta-inducible [OPG] release . Negative_regulation TNFRSF11B TNF 18083042 1854662 These results suggest the existence of fibroblastic cells producing OPG in the synovium , while *suppresses* [OPG] production by inducing apoptosis in those cells . Negative_regulation TNFRSF11B TNF 21992185 2519845 MSU crystals induced the expressions of IL-1 , IL-6 , and RANKL in PBMCs , but *inhibited* [OPG] expression . Negative_regulation TNFRSF11B TNF 23490134 2799547 Differential expression and *mediated* regulation of [TNFRSF11b/osteoprotegerin] production by human melanomas . Negative_regulation TNFRSF11B TNFSF10 9603945 507060 Conversely , *blocks* the anti-osteoclastogenic activity of [OPG] . Negative_regulation TNFRSF1A EPHB2 18442799 1900628 In this study , we show that and p38 MAP kinase are *involved* in the downregulation of cell surface [TNF-R1] upon exposure to Ac-CHX and the subsequent inhibition of TNF-alpha induced NF-kappaB activation . Negative_regulation TNFRSF1A MMP28 9890556 585475 In contrast to pro-TNFalpha surface expression , [TNFRI] surface expression was not *augmented* by these inhibitors in THP-1 cells after LPS stimulation . Negative_regulation TNFRSF1A MMP7 9890556 585490 In contrast to pro-TNFalpha surface expression , [TNFRI] surface expression was not *augmented* by these inhibitors in THP-1 cells after LPS stimulation . Negative_regulation TNFRSF1A TNF 11522182 852741 Our results indicate that HIV-1 Tat may inhibit *induced* repression of TNFR [p55] and thereby amplify TNF-alpha activity in these stably transfected cells . Negative_regulation TNFRSF1A TNF 12646554 1091983 Soluble forms of [TNFR1] ( as well as of TNFR2 ) can be shed from the EC surface and *inhibit* actions . Negative_regulation TNFRSF1A TNF 18397796 1893676 In addition , EGCG attenuated *mediated* down-regulation of [TNFalpha receptor 1 (TNFR1)] , but not TNFR2 . Negative_regulation TNFRSF1A TNF 21737776 2484156 These TNF-a induced changes in mucus mRNA levels required TNF receptor 2 (TNFR2) , whereas induced loss of mucus positive goblet cells *required* [TNFR1] . Negative_regulation TNFRSF1A TNF 21816064 2472808 High glucose induced up-regulation of [TNF-R1] and Fas expression was undetectable in the *presence* of . Negative_regulation TNFRSF1A TNF 23423194 2755347 Our findings suggest that the cytoprotective effects of HO-1 are *mediated* by suppression of mediated apoptotic signaling , specifically by modulating apoptotic DISC formation and mitochondrial [TNFR1] translocation during hepatic I/R . Negative_regulation TNFRSF1A TNF 23921304 2861637 stimulation *resulted* in a significant decrease in [TNFR1] , an effect that was abolished by pretreatment with EGCG . Negative_regulation TNFRSF1A TNF 9166774 432544 In this study , we have identified partial phosphorothioate oligodeoxyribonucleotides ( ODNs ) containing C-5 propynyl or hexynyl derivatives of 2'-deoxyuridine which specifically inhibited [TNFRI] and subsequently *inhibited* the functions of mediated through TNFRI . Negative_regulation TNFRSF1B MMP28 9890556 585497 Surface expression of [TNFRII] was *augmented* by these inhibitors . Negative_regulation TNFRSF1B MMP7 9890556 585512 Surface expression of [TNFRII] was *augmented* by these inhibitors . Negative_regulation TNFRSF1B TNF 20542488 2284813 On the other hand , [etanercept] , *prevented* the inhibitory effect of LPS on salivary secretion and moreover , injected intraglandularly inhibited salivary secretion , being this effect prevented by AM251 and AM630 injected concomitantly . Negative_regulation TNFRSF1B TNF 23874808 2817850 Comparison of TNF levels on the TNFR2 positive and negative T cells is consistent with [TNF/TNFR2] interactions *inducing* feedback downregulation of production by T cells , with greater effects in the lung compared to spleen . Negative_regulation TNFRSF6B TNF 17393415 1728002 [DcR3] is mostly expressed in tumor cells , and it competitively *inhibits* binding of to TNFRs . Negative_regulation TNFRSF6B TNFSF10 15475369 1319198 Instead , in the presence of [DcR3] , engagement *resulted* in an increased activation of caspase-8 , an elevated cleavage of Bid , and enhanced release of Smac and cytochrome c from mitochondria to cytosol compared with TRAIL alone . Negative_regulation TNFSF10 ABL1 12750477 1093552 induced *inhibition* of [TRAIL] transcription in hematopoietic cells may provide a novel mechanism for tumorigenicity in chronic myeloid leukemia . Negative_regulation TNFSF10 AKT1 11429162 831580 Suppression of signaling markedly *enhanced* the apoptotic activity of both TNF and [TRAIL] in LNCaP cells but not in PC-3 cells . Negative_regulation TNFSF10 AKT1 12242663 990164 MEKK1 induced apoptosis requires [TRAIL] death receptor activation and is *inhibited* by through inhibition of MEKK1 cleavage . Negative_regulation TNFSF10 AKT1 12242663 990251 Thus , MEKK1 induced apoptosis requires [TRAIL] death receptor activation and is *blocked* by through inhibition of MEKK1 cleavage . Negative_regulation TNFSF10 AKT1 22998497 2720105 Interestingly , while [TRAIL] *induces* a significant reduction in the levels of ( pAkt ) and phospho-MADD ( pMADD ) in TRAIL-sensitive cells , it fails to do so in TRAIL-resistant cells . Negative_regulation TNFSF10 AKT2 11429162 831581 Suppression of signaling markedly *enhanced* the apoptotic activity of both TNF and [TRAIL] in LNCaP cells but not in PC-3 cells . Negative_regulation TNFSF10 AKT2 12242663 990165 MEKK1 induced apoptosis requires [TRAIL] death receptor activation and is *inhibited* by through inhibition of MEKK1 cleavage . Negative_regulation TNFSF10 AKT2 12242663 990252 Thus , MEKK1 induced apoptosis requires [TRAIL] death receptor activation and is *blocked* by through inhibition of MEKK1 cleavage . Negative_regulation TNFSF10 AKT2 22998497 2720106 Interestingly , while [TRAIL] *induces* a significant reduction in the levels of ( pAkt ) and phospho-MADD ( pMADD ) in TRAIL-sensitive cells , it fails to do so in TRAIL-resistant cells . Negative_regulation TNFSF10 AKT3 11429162 831582 Suppression of signaling markedly *enhanced* the apoptotic activity of both TNF and [TRAIL] in LNCaP cells but not in PC-3 cells . Negative_regulation TNFSF10 AKT3 12242663 990166 MEKK1 induced apoptosis requires [TRAIL] death receptor activation and is *inhibited* by through inhibition of MEKK1 cleavage . Negative_regulation TNFSF10 AKT3 12242663 990253 Thus , MEKK1 induced apoptosis requires [TRAIL] death receptor activation and is *blocked* by through inhibition of MEKK1 cleavage . Negative_regulation TNFSF10 AKT3 22998497 2720107 Interestingly , while [TRAIL] *induces* a significant reduction in the levels of ( pAkt ) and phospho-MADD ( pMADD ) in TRAIL-sensitive cells , it fails to do so in TRAIL-resistant cells . Negative_regulation TNFSF10 APC 17932312 1825534 We report that can *suppress* the proapoptotic mediator [TRAIL] in human umbilical vein endothelial cells , and we have investigated the signaling mechanism . Negative_regulation TNFSF10 APC 17932312 1825535 *inhibited* endothelial [TRAIL] expression and secretion and its induction by cell activation . Negative_regulation TNFSF10 BCL10 21554547 2475622 [TRAIL] *induced* a decrease in Bid , Bcl-2 and protein levels , increase in cleaved Bid and Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 and -3 ) and an increase in the tumour suppressor p53 levels . Negative_regulation TNFSF10 BCL10 21800052 2521520 [TRAIL] *induced* a decrease in Bid , Bcl-2 , , and survivin protein levels , increase in Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 , and -3 ) , cleavage of PARP-1 and an increase in the tumor suppressor p53 levels . Negative_regulation TNFSF10 BCL2 21554547 2475623 [TRAIL] *induced* a decrease in Bid , Bcl-2 and protein levels , increase in cleaved Bid and Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 and -3 ) and an increase in the tumour suppressor p53 levels . Negative_regulation TNFSF10 BCL2 21800052 2521521 [TRAIL] *induced* a decrease in Bid , Bcl-2 , , and survivin protein levels , increase in Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 , and -3 ) , cleavage of PARP-1 and an increase in the tumor suppressor p53 levels . Negative_regulation TNFSF10 BCL3 21554547 2475624 [TRAIL] *induced* a decrease in Bid , Bcl-2 and protein levels , increase in cleaved Bid and Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 and -3 ) and an increase in the tumour suppressor p53 levels . Negative_regulation TNFSF10 BCL3 21800052 2521522 [TRAIL] *induced* a decrease in Bid , Bcl-2 , , and survivin protein levels , increase in Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 , and -3 ) , cleavage of PARP-1 and an increase in the tumor suppressor p53 levels . Negative_regulation TNFSF10 BCL5 21554547 2475619 [TRAIL] *induced* a decrease in Bid , Bcl-2 and protein levels , increase in cleaved Bid and Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 and -3 ) and an increase in the tumour suppressor p53 levels . Negative_regulation TNFSF10 BCL5 21800052 2521517 [TRAIL] *induced* a decrease in Bid , Bcl-2 , , and survivin protein levels , increase in Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 , and -3 ) , cleavage of PARP-1 and an increase in the tumor suppressor p53 levels . Negative_regulation TNFSF10 BCL6 21554547 2475620 [TRAIL] *induced* a decrease in Bid , Bcl-2 and protein levels , increase in cleaved Bid and Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 and -3 ) and an increase in the tumour suppressor p53 levels . Negative_regulation TNFSF10 BCL6 21800052 2521518 [TRAIL] *induced* a decrease in Bid , Bcl-2 , , and survivin protein levels , increase in Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 , and -3 ) , cleavage of PARP-1 and an increase in the tumor suppressor p53 levels . Negative_regulation TNFSF10 BCL9 21554547 2475621 [TRAIL] *induced* a decrease in Bid , Bcl-2 and protein levels , increase in cleaved Bid and Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 and -3 ) and an increase in the tumour suppressor p53 levels . Negative_regulation TNFSF10 BCL9 21800052 2521519 [TRAIL] *induced* a decrease in Bid , Bcl-2 , , and survivin protein levels , increase in Bax levels , loss of the mitochondrial transmembrane potential , cytochrome c release , activation of caspases ( -8 , -9 , and -3 ) , cleavage of PARP-1 and an increase in the tumor suppressor p53 levels . Negative_regulation TNFSF10 BCR 12750477 1093549 *induced* inhibition of [TRAIL] transcription in hematopoietic cells may provide a novel mechanism for tumorigenicity in chronic myeloid leukemia . Negative_regulation TNFSF10 BID 22130162 2530403 Furthermore , *prevented* both IFN-a and [TRAIL] from collapsing the mitochondrial membrane potential ( ??m ) . Negative_regulation TNFSF10 CASP1 9334376 457887 AICD can be blocked by inhibitors in some patients , and this AICD is *mediated* by [TRAIL] . Negative_regulation TNFSF10 CBL 12881518 1142615 *suppressed* [Apo2L/TRAIL-] and TNF-alpha mediated activation of a transfected NF-kappa B-driven luciferase reporter . Negative_regulation TNFSF10 CD4 16736946 1566271 However , soluble ( sCD4-IgG ) efficiently *blocked* IFNalpha production , [TRAIL] and DR5 expression and apoptosis of T helper cells . Negative_regulation TNFSF10 CD47 15385934 1324169 [TRAIL/FP] *induced* no discernible changes in FLIP , DR4 , DR5 , Mcl-1 , or survivin expression , modest declines in levels of DcR2 and , but resulted in the marked transcriptional downregulation of XIAP . Negative_regulation TNFSF10 CD79A 12750477 1093550 induced *inhibition* of [TRAIL] transcription in hematopoietic cells may provide a novel mechanism for tumorigenicity in chronic myeloid leukemia . Negative_regulation TNFSF10 CD79B 12750477 1093551 *induced* inhibition of [TRAIL] transcription in hematopoietic cells may provide a novel mechanism for tumorigenicity in chronic myeloid leukemia . Negative_regulation TNFSF10 CFLAR 18084329 1903365 Conversely ectopic expression of in TRAIL-sensitive , TRAIL-R2 expressing RPM-EP melanoma cells *inhibited* [TRAIL-] and CD95L mediated cell death . Negative_regulation TNFSF10 CFLAR 20876774 2368731 Simultaneous downregulation of c-FLIP ( L ) and ( S ) as well as individual knockdown of either isoform by RNA interference significantly *enhances* [TRAIL] ( tumour necrosis factor related apoptosis inducing ligand ) - and CD95 induced caspase activation and caspase dependent apoptosis . Negative_regulation TNFSF10 CHUK 17237443 1690117 These results present the combination of [TRAIL] stimulation and *inhibition* as a new approach to MCL therapy . Negative_regulation TNFSF10 CTSB 17431792 1748958 activity in U2OS cells was significantly activated shortly after exposure to TRAIL , and the cathepsin B inhibitor , CA074Me , *inhibited* both [TRAIL-] and anti-DR5 mediated apoptosis and delayed the cleavage of Bid . Negative_regulation TNFSF10 CXCL12 23231075 2775271 Importantly , *inhibited* [TRAIL] activation of the apoptotic pathway in GBM , suggesting that AT-MSCs may support GBM development in vivo by at least two distinct mechanisms promoting angiogenesis and inhibiting apoptosis . Negative_regulation TNFSF10 DISC1 20484047 2283420 However , in cells susceptible to TRAIL treatment , [TRAIL] *induces* a reduction in MADD phosphorylation levels resulting in MADD dissociation from , and Fas associated death domain association with DR4 , which allows formation leading to apoptosis . Negative_regulation TNFSF10 DISC2 20484047 2283421 However , in cells susceptible to TRAIL treatment , [TRAIL] *induces* a reduction in MADD phosphorylation levels resulting in MADD dissociation from , and Fas associated death domain association with DR4 , which allows formation leading to apoptosis . Negative_regulation TNFSF10 FADD 18723480 1955923 Dominant negative *inhibited* the synergistic interaction between DATS and [TRAIL] on apoptosis . Negative_regulation TNFSF10 FAS 15849812 1399216 AFP ( 20 mg/L ) could promote the expression of FasL and [TRAIL] , and *inhibit* the expression of and TRAILR of Bel7402 cells . Negative_regulation TNFSF10 FOXO1 12351634 1018858 These findings suggest that the decreased activity of FKHRL1 and in prostate cancers resulting from loss of PTEN *leads* to a decrease in [TRAIL] expression that may contribute to increased survival of the tumor cells . Negative_regulation TNFSF10 FOXO1 21179458 2358270 The inhibition of PI3K/AKT pathway *induced* transcriptional activity resulting in induction of Bim , [TRAIL] , p27/KIP1 , DR4 and DR5 , and inhibition of cyclin D1 . Negative_regulation TNFSF10 FOXO3 12351634 1018859 These findings suggest that the decreased activity of and FKHR in prostate cancers resulting from loss of PTEN *leads* to a decrease in [TRAIL] expression that may contribute to increased survival of the tumor cells . Negative_regulation TNFSF10 FOXO3 21179458 2358271 The inhibition of PI3K/AKT pathway *induced* transcriptional activity resulting in induction of Bim , [TRAIL] , p27/KIP1 , DR4 and DR5 , and inhibition of cyclin D1 . Negative_regulation TNFSF10 FOXO4 21179458 2358272 The inhibition of PI3K/AKT pathway *induced* transcriptional activity resulting in induction of Bim , [TRAIL] , p27/KIP1 , DR4 and DR5 , and inhibition of cyclin D1 . Negative_regulation TNFSF10 FOXO6 21179458 2358269 The inhibition of PI3K/AKT pathway *induced* transcriptional activity resulting in induction of Bim , [TRAIL] , p27/KIP1 , DR4 and DR5 , and inhibition of cyclin D1 . Negative_regulation TNFSF10 HDAC1 18701496 1950467 Here , we show that the inhibitors *induce* [TRAIL] in human breast cancer cells . Negative_regulation TNFSF10 HDAC1 19547714 2099313 We found that inhibition in B-CLL cells *led* to increased [TRAIL] receptor expression , increased caspase activation , decreased expression of antiapoptotic regulators such as Bcl-2 , and ultimately , enhanced TRAIL induced apoptosis . Negative_regulation TNFSF10 HDAC1 23247046 2793626 We here report that inhibition of using the specific class I HDAC inhibitor SNDX-275 *restored* the expression of Nur77/Nor1 and induced expression of activator protein 1 transcription factors c-Jun and JunB , and of death receptor [TRAIL] , in AML cells and in CD34 ( + ) /38 ( - ) AML LSCs . Negative_regulation TNFSF10 HDAC2 18701496 1950468 Here , we show that the inhibitors *induce* [TRAIL] in human breast cancer cells . Negative_regulation TNFSF10 HDAC2 19547714 2099314 We found that inhibition in B-CLL cells *led* to increased [TRAIL] receptor expression , increased caspase activation , decreased expression of antiapoptotic regulators such as Bcl-2 , and ultimately , enhanced TRAIL induced apoptosis . Negative_regulation TNFSF10 HDAC2 23247046 2793627 We here report that inhibition of using the specific class I HDAC inhibitor SNDX-275 *restored* the expression of Nur77/Nor1 and induced expression of activator protein 1 transcription factors c-Jun and JunB , and of death receptor [TRAIL] , in AML cells and in CD34 ( + ) /38 ( - ) AML LSCs . Negative_regulation TNFSF10 ICAM1 15644410 1394916 Unexpectedly , the antiadhesive activity of [TRAIL] was not *due* to interference with the nuclear factor kappaB (NF-kappaB) mediated up-regulation of surface ( ICAM-1 ) , vascular cell adhesion molecule 1 ( VCAM-1 ) , and E-selectin adhesion molecules in response to inflammatory cytokines . Negative_regulation TNFSF10 IFNG 10395688 627527 CMV infection increased the expression of TRAIL-R1 and -R2 , whereas *down-regulated* the expression of [TRAIL-Rs] on uninfected fibroblasts . Negative_regulation TNFSF10 IGF1R 18178561 1875734 [TRAIL] is required for serum-inducible IGF1R expression , and antisense *inhibits* TRAIL induced VSMC proliferation . Negative_regulation TNFSF10 IL12A 11257133 794414 Administration of therapeutic doses of interleukin (IL)-12 , a powerful inducer of interferon (IFN)-gamma production by NK cells and NKT cells , upregulated [TRAIL] expression on liver , spleen , and lung NK cells , and *suppressed* metastases in both liver and lung in a TRAIL dependent fashion . Negative_regulation TNFSF10 IL12B 11257133 794415 Administration of therapeutic doses of interleukin (IL)-12 , a powerful inducer of interferon (IFN)-gamma production by NK cells and NKT cells , upregulated [TRAIL] expression on liver , spleen , and lung NK cells , and *suppressed* metastases in both liver and lung in a TRAIL dependent fashion . Negative_regulation TNFSF10 IRF9 19752753 2168279 In IFN-alpha treated OVCAR3 cells , *inhibited* transcription of [TRAIL] whereas Stat1-RNAi did not , suggesting that the transcription of TRAIL induced by IFN-alpha predominantly required IRF9 . Negative_regulation TNFSF10 MADD 22998497 2720108 Interestingly , while [TRAIL] *induces* a significant reduction in the levels of phospho-Akt ( pAkt ) and ( pMADD ) in TRAIL-sensitive cells , it fails to do so in TRAIL-resistant cells . Negative_regulation TNFSF10 MAP3K7 20062539 2193813 To determine the *role* of in [TRAIL] signalling , we analyzed the effects of adding TRAIL to mouse embryonic fibroblasts ( MEFs ) derived from TAK1 conditional knockout mice . Negative_regulation TNFSF10 MAPK7 12219026 986625 The ability of PMA to partially suppress [TRAIL-] and TNF induced cell death was *inhibited* by . Negative_regulation TNFSF10 MTOR 21666560 2442729 Especially EGFR mutations , anti-angiogenesis , multi kinase inhibition , vascular disrupting agents , vaccines , inhibitors , [TRAIL] *inhibition* and several biomarkers are highlighted including current study results . Negative_regulation TNFSF10 NAB2 22128144 2542312 Enforced expression of Nab2 prevents [TRAIL] induction after restimulation of primary helpless CD8 ( + ) T cells , and expression of a dominant negative form of in helped CD8 ( + ) T cells *impairs* their secondary proliferative response that is reversible by TRAIL blockade . Negative_regulation TNFSF10 NFKB1 11313369 805402 The *role* of in [TNF related apoptosis inducing ligand] ( TRAIL ) -induced apoptosis of melanoma cells . Negative_regulation TNFSF10 NFKB1 11468181 840880 inhibitors , such as SN50 ( a cell-permeable inhibitor of the nuclear translocation and transcriptional activity of NF-kappaB ) or the proteasome inhibitor PS-341 , *enhanced* the proapoptotic activity of [TRAIL/Apo2L] against TRAIL-sensitive MM cells , whereas SN50 reversed the TRAIL resistance of ARH-77 and IM-9 MM cells . Negative_regulation TNFSF10 NFKB1 11772267 890520 Moreover , inhibitors such as SN50 ( a cell permeable inhibitor of NF-kappaB nuclear translocation ) as well as the proteasome inhibitor PS-341 , which is currently in Phase II clinical trials , also *enhanced* the pro-apoptotic activity of [TRAIL/Apo2L] in MM cells . Negative_regulation TNFSF10 NFKB1 11948689 930244 Conversely , expression of the p65 subunit of *suppressed* TNF-alpha- , [TRAIL-] , and serum deprivation induced cell death . Negative_regulation TNFSF10 NFKB1 12173037 974378 conversely , transcriptional activity *attenuates* their [Apo2L/TRAIL-sensitivity] . Negative_regulation TNFSF10 NFKB1 15644410 1394917 Unexpectedly , the antiadhesive activity of [TRAIL] was not *due* to interference with the mediated up-regulation of surface intercellular adhesion molecule 1 ( ICAM-1 ) , vascular cell adhesion molecule 1 ( VCAM-1 ) , and E-selectin adhesion molecules in response to inflammatory cytokines . Negative_regulation TNFSF10 NFKB1 17070520 1649809 Furthermore , activation of cJun and suppression of by sodium arsenite *resulted* in upregulation of the endogenous [TRAIL] and downregulation of the cFLIP gene expression ( which encodes one of the main anti-apoptotic proteins in melanomas ) followed by cFLIP protein degradation and , finally , by acceleration of TRAIL induced apoptosis . Negative_regulation TNFSF10 NFKB1 20542572 2301994 Pharmacological inhibition of the transcription factor , NF-kappaB also profoundly decreased TRAIL expression , suggesting that is *involved* in the regulation of [TRAIL] expression in activated human NK cells . Negative_regulation TNFSF10 PCNA 18483205 1939088 Our data indicate that in human CD8+ T-cell blasts , Fas ligation , and especially [Apo2L/TRAIL] *induce* the p53 dependent decrease in levels . Negative_regulation TNFSF10 PI3 11429162 831583 Suppression of signaling markedly *enhanced* the apoptotic activity of both TNF and [TRAIL] in LNCaP cells but not in PC-3 cells . Negative_regulation TNFSF10 PI3 12140294 985191 Inhibition of with the chemical inhibitor wortmannin *increased* [TNF related apoptosis inducing ligand] ( TRAIL ; Negative_regulation TNFSF10 PI3 12140294 985194 Activation of by pretreatment with IGF-1 , a gut trophic factor , markedly *attenuated* the induction of [TRAIL] by wortmannin . Negative_regulation TNFSF10 PI3 12140294 985198 Taken together , our findings demonstrate *induction* of the [TRAIL] by inhibition of in colon cancer cell lines . Negative_regulation TNFSF10 PTEN 12140294 985192 Similarly , overexpression of the tumor suppressor protein , an antagonist of PI 3-kinase signaling , *resulted* in the increased expression of [TRAIL] . Negative_regulation TNFSF10 RBBP4 18701496 1950469 Here , we show that the inhibitors *induce* [TRAIL] in human breast cancer cells . Negative_regulation TNFSF10 RBBP4 19547714 2099315 We found that inhibition in B-CLL cells *led* to increased [TRAIL] receptor expression , increased caspase activation , decreased expression of antiapoptotic regulators such as Bcl-2 , and ultimately , enhanced TRAIL induced apoptosis . Negative_regulation TNFSF10 RBBP4 23247046 2793628 We here report that inhibition of using the specific class I HDAC inhibitor SNDX-275 *restored* the expression of Nur77/Nor1 and induced expression of activator protein 1 transcription factors c-Jun and JunB , and of death receptor [TRAIL] , in AML cells and in CD34 ( + ) /38 ( - ) AML LSCs . Negative_regulation TNFSF10 RBBP7 18701496 1950470 Here , we show that the inhibitors *induce* [TRAIL] in human breast cancer cells . Negative_regulation TNFSF10 RBBP7 19547714 2099316 We found that inhibition in B-CLL cells *led* to increased [TRAIL] receptor expression , increased caspase activation , decreased expression of antiapoptotic regulators such as Bcl-2 , and ultimately , enhanced TRAIL induced apoptosis . Negative_regulation TNFSF10 RBBP7 23247046 2793629 We here report that inhibition of using the specific class I HDAC inhibitor SNDX-275 *restored* the expression of Nur77/Nor1 and induced expression of activator protein 1 transcription factors c-Jun and JunB , and of death receptor [TRAIL] , in AML cells and in CD34 ( + ) /38 ( - ) AML LSCs . Negative_regulation TNFSF10 RELA 11313369 805403 The *role* of in [TNF related apoptosis inducing ligand] ( TRAIL ) -induced apoptosis of melanoma cells . Negative_regulation TNFSF10 RELA 11468181 840881 inhibitors , such as SN50 ( a cell-permeable inhibitor of the nuclear translocation and transcriptional activity of NF-kappaB ) or the proteasome inhibitor PS-341 , *enhanced* the proapoptotic activity of [TRAIL/Apo2L] against TRAIL-sensitive MM cells , whereas SN50 reversed the TRAIL resistance of ARH-77 and IM-9 MM cells . Negative_regulation TNFSF10 RELA 11772267 890521 Moreover , inhibitors such as SN50 ( a cell permeable inhibitor of NF-kappaB nuclear translocation ) as well as the proteasome inhibitor PS-341 , which is currently in Phase II clinical trials , also *enhanced* the pro-apoptotic activity of [TRAIL/Apo2L] in MM cells . Negative_regulation TNFSF10 RELA 11948689 930245 Conversely , expression of the p65 subunit of *suppressed* TNF-alpha- , [TRAIL-] , and serum deprivation induced cell death . Negative_regulation TNFSF10 RELA 12173037 974379 conversely , transcriptional activity *attenuates* their [Apo2L/TRAIL-sensitivity] . Negative_regulation TNFSF10 RELA 15644410 1394918 Unexpectedly , the antiadhesive activity of [TRAIL] was not *due* to interference with the mediated up-regulation of surface intercellular adhesion molecule 1 ( ICAM-1 ) , vascular cell adhesion molecule 1 ( VCAM-1 ) , and E-selectin adhesion molecules in response to inflammatory cytokines . Negative_regulation TNFSF10 RELA 17070520 1649810 Furthermore , activation of cJun and suppression of by sodium arsenite *resulted* in upregulation of the endogenous [TRAIL] and downregulation of the cFLIP gene expression ( which encodes one of the main anti-apoptotic proteins in melanomas ) followed by cFLIP protein degradation and , finally , by acceleration of TRAIL induced apoptosis . Negative_regulation TNFSF10 RELA 20542572 2301995 Pharmacological inhibition of the transcription factor , NF-kappaB also profoundly decreased TRAIL expression , suggesting that is *involved* in the regulation of [TRAIL] expression in activated human NK cells . Negative_regulation TNFSF10 SP1 20150555 2227512 Mutational studies confirmed a *role* for in injury- and FGF-2-inducible [TRAIL] transcription . Negative_regulation TNFSF10 SP1 21603612 2435905 Knockdown of NFATc1 increased Sp1 transcription factor binding to the [TRAIL] promoter and , importantly , inhibition of , by chemical inhibition or RNA interference , *increased* TRAIL expression . Negative_regulation TNFSF10 SYT1 11948689 930243 Conversely , expression of the subunit of NF-kappaB *suppressed* TNF-alpha- , [TRAIL-] , and serum deprivation induced cell death . Negative_regulation TNFSF10 TNFRSF10B 19752753 2168282 Subsequently , *inhibited* both antiproliferative activities of IFN-alpha and [TRAIL] , suggesting that TRAIL-R2 mediated both IFN-alpha and TRAIL signals to elicit their antiproliferative activities . Negative_regulation TNFSF10 TNFRSF10D 15385934 1324168 [TRAIL/FP] *induced* no discernible changes in FLIP , DR4 , DR5 , Mcl-1 , or survivin expression , modest declines in levels of and c-IAP , but resulted in the marked transcriptional downregulation of XIAP . Negative_regulation TNFSF10 TNFRSF11B 11467075 766059 However , also *blocks* [TRAIL] and may not be sufficiently specific in long term therapy , but it is hoped that inhibitors of the interaction of TRANCE and its specific signalling receptor , RANK , can be rationally designed . Negative_regulation TNFSF10 TNFRSF11B 17702740 1805995 *inhibited* native [TRAIL] from binding the TRAILR1 at 37 degrees C in vitro . Negative_regulation TNFSF10 TNFRSF11B 18000166 1860127 Because *inhibits* the pro-tumoricidal activity of [TNF related apoptosis inducing ligand] , our findings suggest that , besides its well documented functions within the malignant cancer cells , the ability of p53 to down-modulate OPG production by endothelial cells may be an additional important mechanism whereby it exerts non-cell-autonomous tumor suppression function . Negative_regulation TNFSF10 TNFRSF11B 18338379 1912468 In addition , the expression of [TRAIL] by osteoclasts was not affected in the *presence* of . Negative_regulation TNFSF10 TNFRSF11B 18338379 1912469 Our findings suggest that inhibits osteoclast apoptosis , at least in part , by binding and thus *inhibiting* endogenously produced [TRAIL] in human osteoclast cultures . Negative_regulation TNFSF10 TNFRSF11B 20818644 2388968 can also bind and *inhibit* the activity of the [TNF related apoptosis inducing ligand] ( Apo2L/TRAIL ) , raising the possibility that the anticancer efficacy of soluble Apo2L/TRAIL may be abrogated in the bone microenvironment where OPG expression is high . Negative_regulation TNFSF10 TP53 10933923 720348 The TRAIL decoy receptor TRUNDD ( DcR2 , TRAIL-R4 ) is induced by overexpression and can *delay* [TRAIL-] , p53- , and KILLER/DR5 dependent colon cancer apoptosis . Negative_regulation TNFSF10 TRIM26 15849812 1399220 For Jurkat cell line , could *suppress* the expression of FasL and [TRAIL] , and stimulate the expression of Fas and TRAILR . Negative_regulation TNFSF10 VCAM1 15644410 1394915 Unexpectedly , the antiadhesive activity of [TRAIL] was not *due* to interference with the nuclear factor kappaB (NF-kappaB) mediated up-regulation of surface intercellular adhesion molecule 1 ( ICAM-1 ) , ( VCAM-1 ) , and E-selectin adhesion molecules in response to inflammatory cytokines . Negative_regulation TNFSF11 MAP2K6 16498455 1624261 TAK1-DN , , and SB203580 , but not MKK3-DN , also *suppressed* [RANKL] stimulation of NF-kappaB transcription activity in a manner dependent on p65 phosphorylation on Ser-536 . Negative_regulation TNFSF11 TNF 14969390 1209217 Although critical *roles* of in inflammatory arthritis and [RANKL] in bone resorption have been firmly established , a central controversy remains about the extent to which TNFalpha can compensate for RANKL during osteoclastogenesis and the stage at which RANK signaling is required for osteoclastogenesis . Negative_regulation TNFSF11 TNF 18495459 2010393 As expected , up-regulated RANKL mRNA and polyphenols *suppressed* [RANKL] expression without altering OPG . Negative_regulation TNFSF11 TNF 25228904 2958351 Supporting an imbalance toward osteoblastogenesis , [RANKL] expression was *inhibited* by and IL-17A . Negative_regulation TNFSF12 EPHB2 24037740 2885399 In vitro [TWEAK] induction of proinflammatory factors was *prevented* by EGFR , or ADAM17 inhibition . Negative_regulation TNFSF13B TLR7 17907168 1812679 Moreover , we found that IFNgamma induced [BAFF] synthesis is inhibited by simultaneous *stimulation* with either ligands or TNFalpha . Negative_regulation TNFSF13B TNF 18050196 1833208 To address the hypothesis that blockade can *result* in increased levels of interferon-alpha (IFNalpha) and [BAFF] , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Negative_regulation TNFSF4 IL1B 15696085 1372142 alone had no effect , but it *attenuated* the TNF induced expression of both CD40 and [OX40 ligand] . Negative_regulation TNMD ITGB2 11261794 794536 The *role* of and VLA-4 in chemokine induced T cell [transendothelial migration (TEM)] across cytokine activated endothelium has not been examined . Negative_regulation TNMD ITGB2 16270641 1479150 Analytical results showed that ( 1 ) ox-LDL furthered monocyte L-selectin shedding and expression , and an attendant increase in TEM of monocyte , while treating the monocyte with Mac-1 antibody *inhibited* the ox-LDL promoted [TEM] of monocyte ; Negative_regulation TNMD TNF 15481136 1320345 These results demonstrate that stimulation with and IFN-gamma triggers expression of membrane bound FKN on both HUVEC and BMVEC , but *prevents* [TEM] of CD16+ monocytes in response to soluble FKN . Negative_regulation TNNT2 MAP3K5 12819028 1103858 Moreover , overexpression of constitutively active *induces* [cTnT] phosphorylation and inhibits shortening and calcium transient in adult cardiomyocytes . Negative_regulation TNNT2 SP3 16617124 1583000 *represses* Sp1 mediated transcriptional activation of the [cTnT] gene in embryonic cardiomyocytes . Negative_regulation TNP1 TNFSF10 12576026 1029622 In an experimental system where TNP-specific Ab production was induced by immunization with TNP modified syngeneic B lymphoma cells , expression of on these cells significantly *reduced* [TNP-specific] Ab production , especially of IgG1 subclass , without affecting T cell priming . Negative_regulation TNP2 TNFSF10 12576026 1029623 In an experimental system where TNP-specific Ab production was induced by immunization with TNP modified syngeneic B lymphoma cells , expression of on these cells significantly *reduced* [TNP-specific] Ab production , especially of IgG1 subclass , without affecting T cell priming . Negative_regulation TNPO1 MIP 18768846 1957121 Cathelicidin inhibited HA induced [MIP-2] release from mouse bone marrow derived macrophages in a CD44 dependent manner but did not *inhibit* MALP2 induced release . Negative_regulation TNS1 NPY 3840319 51974 also *reduced* the [TNS] induced ( 2 Hz for 20 s ) , fractional [ 3H ] NA release by 40 % without affecting the contractile response . Negative_regulation TOB1 IL1B 12372467 996443 *down-regulated* [Tob-1] in endometriotic stromal cells , but had no significant effect on normal endometrial stromal cells . Negative_regulation TOB1 RORC 24307243 2921428 However , was not directly *involved* in the regulation of [Tob1] expression , whereas IL4I1 silencing in Th17 cells induced a substantial decrease of Tob1 expression . Negative_regulation TOLLIP IL1B 19273233 2045823 In vitro experiments showed that stimulation also significantly *reduced* the association of [Tollip] with IRAK-1 and increased NF-kappaB binding activity in neonatal cardiomyocytes . Negative_regulation TP53 AGR2 23029506 2681048 However , the general biochemical functions of AGR2 in human cells remain undefined , and the signaling mechanisms that drive to *inhibit* [p53] are still not clearly illustrated . Negative_regulation TP53 ANGPT1 15763944 1352568 Moreover , *inhibits* DOX induced up-regulation of [p53] through PI3K/Akt . Negative_regulation TP53 AXIN2 19731416 2134370 An axin mutation promotes carcinogenesis in Axin ( Fu ) /+ ( Axin Fused ) mice , consistent with a dominantnegative *role* for ( Fu ) in [p53] activation . Negative_regulation TP53 CAPN8 17846083 1858263 Prevention of activation by calpeptin or antisense oligonucleotides *augmented* strain induced [p53] expression and transcriptional activity , resulting in a further increase of apoptotic rate . Negative_regulation TP53 CCND1 20179194 2215780 Further studies revealed that BME treatment enhanced [p53] , p21 , and pChk1/2 and *inhibited* cyclin B1 and expression , suggesting an additional mechanism involving cell cycle regulation . Negative_regulation TP53 CCND1 21695715 2494305 In the cell cycle related proteins , SJSZ glycoprotein ( 50 µg/ml ) significantly *enhances* the expression of [p53] , p21 , and p27 , whereas it suppressed the activity of . Negative_regulation TP53 CCND1 22191569 2568778 BME treatment enhanced [cellular tumor antigen p53] , cyclin dependent kinase inhibitor 1A ( also called p21 ) , and cyclic AMP dependent transcription factor-3 levels and *inhibited* , D2 , and D3 , and mitogen activated protein kinase 8 ( also called Janus kinase ) expression , suggesting an additional mechanism involving cell cycle regulation and cell survival . Negative_regulation TP53 CTGF 22438586 2594518 CCN2 overexpression enhanced APF 's antiproliferative activity , whereas knockdown *diminished* APF induced [p53] expression . Negative_regulation TP53 DAPK1 22170404 2563267 It stimulated the phosphorylation of adenosine monophosphate activated protein kinase ( AMPK ) and [p53] , but *inhibited* the phosphorylation of . Negative_regulation TP53 EMP1 12508535 1027473 Down-regulation of bcl-2 expression and up-regulation of [p53] expression were *induced* by . Negative_regulation TP53 EPHB2 12048219 968716 Ectopic expression of PKCalpha or -zeta did not affect p38 kinase or but *inhibited* the [p53] accumulation and caspase-3 activation that are required for NO-induced apoptosis of chondrocytes . Negative_regulation TP53 EPHB2 14511359 1146592 Inhibited the activation of p42/p44 mitogen activated protein kinase (MAPK) by PD98059 , a specific inhibitor of , significantly decreased cell viability and *enhanced* the expression of [p53] induced by ASA . Negative_regulation TP53 EPHB2 15212949 1262417 Decreasing with the pharmacological inhibitors , PD98059 and U0126 , markedly *suppresses* hyperoxia stimulated [phospho-p53] ( Ser15 ) , p53 , and p21 ( CIP1 ) , and also restores the hyperoxia reduced kinase activities of cyclin D1/E1-Cdks . Negative_regulation TP53 EPHB2 15899123 1408706 Phosphorylation of *resulted* in up-regulation of [p53] expression , which was blocked by mitogen activated protein kinase (MEK) , inhibitor PD 98059 . Negative_regulation TP53 EPHB2 18796294 1976164 In addition , TNFalpha induced [p53] activation was *reduced* by or JNK inhibition , but it was not affected by p38 inhibition . Negative_regulation TP53 EPHB2 19699177 2144551 In addition , we discovered that interruption of p53 activation decreased oridonin induced apoptosis , and blocking by specific inhibitors or siRNA *suppressed* oridonin induced [p53] activation . Negative_regulation TP53 EPHB2 20664969 2298211 Immunoblot analysis demonstrated that oridonin treatment increased expression levels of p-JNK , p-p38 , [p-p53] and p21 , elevated the level of cyclin B1/p-Cdc2 ( Tyr15 ) complex , and *inhibited* the expression of . Negative_regulation TP53 EPHB2 24309939 2877889 When we pre treated cells with , JNK , p38 , [p53] *inhibitor* or NAC followed by WA treatment , only ERK and p53 inhibitors blocked WA-induced apoptosis and G2/M arrest . Negative_regulation TP53 FAS 10660538 664481 The functional conservation of p53 dependent Fas up-regulation argues strongly in favor of its biological importance and suggests that murine models may be used to study further the in vivo *role* of in the [p53] response . Negative_regulation TP53 FAS 14767544 1207626 In SK-Br3 cells , cerulenin induced inhibition of activity *resulted* in down-regulation of [p53] , and up-regulation of cyclin dependent kinase inhibitor (CDKi) p21WAF1/CIP1 . Negative_regulation TP53 FAS 15207713 1261659 The observation that overexpression of [p53] by Adp53 infection in MCF-7 does not *induce* increased protein levels nor apoptotic cell death suggests that p53 overexpression is required but not sufficient enough for apoptosis . Negative_regulation TP53 FAS 19190080 2079371 Several recent studies suggest that deregulations in the apoptotic pathways ( such as [p53] , , Bcl-2 family proteins , *inhibitor* of apoptosis proteins ) , survival pathways ( PI3K/AKT , MAPK ) , hormone receptor signaling pathways ( progesterone receptor ) , Cyclooxygenase-2 and Her-2 are considered as key factors involved in the onset and maintenance of therapeutic resistance , suggesting that resistance is a multi-factorial phenomenon . Negative_regulation TP53 FOXA1 19866472 2203324 Overexpression of *induces* apoptosis through the upregulation and accumulation of cytoplasmic [p53] in prostate cancer cells . Negative_regulation TP53 FOXO1 22306819 2560491 In addition , we found that SIRT1 maintains prematurity of hematopoietic cells through ROS elimination , activation , and [p53] *inhibition* . Negative_regulation TP53 ID1 19079342 2030888 In promoter assay with serial deletion and chromatin immunoprecipitation assay , the binding of [p53] to the PTEN promoter was *reduced* by , suggesting that Id-1 regulates PTEN transcription through its p53 modulation . Negative_regulation TP53 ID1 21630092 2489766 *induced* inhibition of [p53] facilitates endothelial cell migration and tube formation by regulating the expression of beta1-integrin . Negative_regulation TP53 IFI27 8654372 366856 Expression of Zta results in induction of the tumor suppressor protein , [p53] , and the cyclin dependent kinase *inhibitors* , p21 and , as well as accumulation of hypophosphorylated pRb . Negative_regulation TP53 MAP2K6 20215498 2223315 In this study , antileukemic effects of combined inhibition by AZD6244 and nongenotoxic [p53] *activation* by MDM2 antagonist Nutlin-3a were investigated . Negative_regulation TP53 MAP2K6 21671008 2460056 Blocking significantly *suppressed* a-PGG induced [p53] and Bax elevation . Negative_regulation TP53 MAP2K6 21957016 2507301 We show that , in stem-like glioblastoma cells , inhibition reduced MDM2 expression and that inhibition of either MEK or MDM2 *resulted* in [p53] activation accompanied by p53 dependent downregulation of MGMT expression . Negative_regulation TP53 NMNAT2 24552824 2924485 Furthermore , knockdown of NMNAT-2 significantly reduces cellular NAD ( + ) levels and protects cells from p53 dependent cell death upon DNA damage , suggesting an important functional *role* of in [p53] mediated signaling . Negative_regulation TP53 PADI3 18505818 1933869 Here , we report that 4 , a histone citrullination enzyme , is *involved* in the repression of [p53] target genes . Negative_regulation TP53 PLAU 22140072 2557870 Thus [p53] is increased and *inhibits* expression of and uPAR while increasing PAI-1 , changes that promote ATII cell apoptosis in mice with BLM induced ALI . Negative_regulation TP53 PLAU 22140072 2557874 We show that CSP , an intervention targeting this pathway , protects the lung epithelium from apoptosis and prevents PF in BLM induced lung injury via *mediated* inhibition of [p53] and PAI-1 . Negative_regulation TP53 S100B 11454863 850635 Consequently , *inhibits* [p53 tetramer] formation and p53 phosphorylation mediated by protein kinase C , on p53 C-terminal end . Negative_regulation TP53 S100B 11454863 850637 The can still interact with p53 in the absence of p53 extreme C-terminal end and *reduce* the expression of [p53] downstream effector genes . Negative_regulation TP53 S100B 1454855 205560 Furthermore , and of particular interest , we have shown that purified p53 undergoes temperature dependent oligomerization and that the interaction between and p53 not only *induces* total inhibition of [p53] oligomerization but also promotes disassembly of the p53 oligomers . Negative_regulation TP53 S100B 15178678 1273625 Down-regulation of [p53] in primary malignant melanoma cells is likely the *result* of a direct interaction with , which was observed by co-immunoprecipitation experiments . Negative_regulation TP53 S100B 23313430 2746585 Calcium dependent binding of dimeric ( ßß ) to p53-NRD blocks access to these PTM sites and *disrupts* the [p53 tetramer] to inhibit p53 activation . Negative_regulation TP53 SNCAIP 16495229 1548804 Furthermore , we establish that drastically *reduces* [p53] transcriptional activity and expression and lowers p53 promoter transactivation and mRNA levels . Negative_regulation TP53 TNF 11561906 862732 By suppressing spontaneous apoptosis TGF-beta as well as *inhibited* [p53] gene expression while that of the p21WAF1 gene was increased . Negative_regulation TP53 TNF 14612962 1163450 This study was carried out to determine if caused oxidative DNA damage in primary cultures of murine hepatocytes and whether any damage would *result* in the induction of the [tumor suppressor p53] and cell-cycle arrest . Negative_regulation TP53 TNF 18753141 1980028 These results demonstrate that S100A6 is *induced* by via an NF-kappaB dependent mechanism , serving a role in homeostasis to limit tumor necrosis factor-alpha induced apoptosis by regulating [p53] phosphorylation . Negative_regulation TP53 TNF 21738216 2532206 Stimulation of HAECs with *led* to an increased expression of p73 protein and a reduction in the levels of [p53] . Negative_regulation TP53 TP63 23420876 2755287 Our data provide evidence of a physiological interaction between p63 with p53 whereby translocation of p63 to the mitochondria occurred through a codependent process with p53 , whereas accumulation of [p53] in the nucleus was *prevented* by . Negative_regulation TP63 ABL1 16885742 1596356 Overexpression of in the absence of Gleevec *results* in higher levels of [p63] than those treated with Gleevec , implicating c-Abl kinase activity as a regulator of p63 protein stability . Negative_regulation TP63 AKT1 23545251 2763003 In addition , KGFR induced a ligand dependent decrease of [p63] through a miR-203 independent mechanism and this effect was *blocked* by inhibition of the signaling , which is the main pathway involved in KGFR dependent keratinocyte differentiation , suggesting that alterations of the KGFR/p63 crosstalk are responsible for the impairment of keratinocyte differentiation induced by 16E5 and that the opposite tumor-suppressive action of KGFR and oncogenic role of E5 might both involve p63 . Negative_regulation TP63 AKT2 23545251 2763004 In addition , KGFR induced a ligand dependent decrease of [p63] through a miR-203 independent mechanism and this effect was *blocked* by inhibition of the signaling , which is the main pathway involved in KGFR dependent keratinocyte differentiation , suggesting that alterations of the KGFR/p63 crosstalk are responsible for the impairment of keratinocyte differentiation induced by 16E5 and that the opposite tumor-suppressive action of KGFR and oncogenic role of E5 might both involve p63 . Negative_regulation TP63 AKT3 23545251 2763005 In addition , KGFR induced a ligand dependent decrease of [p63] through a miR-203 independent mechanism and this effect was *blocked* by inhibition of the signaling , which is the main pathway involved in KGFR dependent keratinocyte differentiation , suggesting that alterations of the KGFR/p63 crosstalk are responsible for the impairment of keratinocyte differentiation induced by 16E5 and that the opposite tumor-suppressive action of KGFR and oncogenic role of E5 might both involve p63 . Negative_regulation TP63 BCR 24117128 2863689 engagement *led* to repression of [TP63] mRNA expression in malignant B cells , while pharmacological inhibition of BCR signalling prevented TP63 downregulation . Negative_regulation TP63 BCR 24117128 2863690 MIR21 , known to target TAp63 , correlated inversely with TAp63 expression in CLL , and *mediated* downregulation of [TP63] was accompanied by MIR21 upregulation in most CLL samples . Negative_regulation TP63 CD79A 24117128 2863691 MIR21 , known to target TAp63 , correlated inversely with TAp63 expression in CLL , and *mediated* downregulation of [TP63] was accompanied by MIR21 upregulation in most CLL samples . Negative_regulation TP63 CD79B 24117128 2863692 MIR21 , known to target TAp63 , correlated inversely with TAp63 expression in CLL , and *mediated* downregulation of [TP63] was accompanied by MIR21 upregulation in most CLL samples . Negative_regulation TP63 CDKN1A 17018588 1630146 In normal primary human keratinocytes , we find that inhibition of endogenous [p63] by RNA interference ( RNAi ) *induces* ( CIP1 ) expression , inhibits cell cycle progression , and ultimately promotes cellular senescence . Negative_regulation TP63 CISH 16303184 1502915 The studies demonstrated that <9-cis-RA> *inhibited* the production of nitric oxide ( NO ) as well as the pro-inflammatory cytokines TNF-alpha , IL-1beta and IL-12 [p40] by LPS stimulated microglia . Negative_regulation TP63 CKAP4 15922574 1440362 is the identity switch for uterine/vaginal epithelial cell fate , and disruption of [p63] expression by diethylstilbestrol (DES) *induces* cervical/vaginal adenosis in mice . Negative_regulation TP63 DES 14998922 1220491 from postnatal day 1 to 5 *inhibited* induction of [p63] in cervicovaginal epithelium via epithelial ERalpha . Negative_regulation TP63 DES 14998922 1220492 The inhibitory effect of was transient , and most cervicovaginal epithelial cells *recovered* expression of [p63] by 2 days after discontinuation of DES-treatment . Negative_regulation TP63 FGFR2 23545251 2763002 In addition , *induced* a ligand dependent decrease of [p63] through a miR-203 independent mechanism and this effect was blocked by inhibition of the PI3K/Akt signaling , which is the main pathway involved in KGFR dependent keratinocyte differentiation , suggesting that alterations of the KGFR/p63 crosstalk are responsible for the impairment of keratinocyte differentiation induced by 16E5 and that the opposite tumor-suppressive action of KGFR and oncogenic role of E5 might both involve p63 . Negative_regulation TP63 GNAS 22852877 2671419 Here we show that the activation of proteins through PMT *suppresses* LPS stimulated [IL-12p40] production and eventually impairs the T cell activating ability of LPS treated monocytes . Negative_regulation TP63 GNB1 22852877 2671420 Here we show that the activation of proteins through PMT *suppresses* LPS stimulated [IL-12p40] production and eventually impairs the T cell activating ability of LPS treated monocytes . Negative_regulation TP63 GNG2 22852877 2671421 Here we show that the activation of proteins through PMT *suppresses* LPS stimulated [IL-12p40] production and eventually impairs the T cell activating ability of LPS treated monocytes . Negative_regulation TP63 IFI16 17702989 1788764 Overexpression of *enhanced* the LPS induced IkappaB-zeta , [IL-12p40] and NF-kappaB promoter activities , while anti-sense ( AS ) RNA against Ifi202 strongly suppressed them in a monocytic cell line , RAW 264.7 . Negative_regulation TP63 IFI27 17702989 1788765 Overexpression of *enhanced* the LPS induced IkappaB-zeta , [IL-12p40] and NF-kappaB promoter activities , while anti-sense ( AS ) RNA against Ifi202 strongly suppressed them in a monocytic cell line , RAW 264.7 . Negative_regulation TP63 IFI30 17702989 1788766 Overexpression of *enhanced* the LPS induced IkappaB-zeta , [IL-12p40] and NF-kappaB promoter activities , while anti-sense ( AS ) RNA against Ifi202 strongly suppressed them in a monocytic cell line , RAW 264.7 . Negative_regulation TP63 IFI35 17702989 1788767 Overexpression of *enhanced* the LPS induced IkappaB-zeta , [IL-12p40] and NF-kappaB promoter activities , while anti-sense ( AS ) RNA against Ifi202 strongly suppressed them in a monocytic cell line , RAW 264.7 . Negative_regulation TP63 IFI44 17702989 1788762 Overexpression of *enhanced* the LPS induced IkappaB-zeta , [IL-12p40] and NF-kappaB promoter activities , while anti-sense ( AS ) RNA against Ifi202 strongly suppressed them in a monocytic cell line , RAW 264.7 . Negative_regulation TP63 IFI6 17702989 1788763 Overexpression of *enhanced* the LPS induced IkappaB-zeta , [IL-12p40] and NF-kappaB promoter activities , while anti-sense ( AS ) RNA against Ifi202 strongly suppressed them in a monocytic cell line , RAW 264.7 . Negative_regulation TP63 IFNB1 10861095 705284 We demonstrate that significantly *inhibits* inducible IL-12 [p40] up to 80 % and biologically active IL-12 p70 up to 70 % beginning at a dose of 10 IU/ml . Negative_regulation TP63 IL10 14993278 1215971 *inhibits* interleukin-12 [p40] gene transcription by targeting a late event in the activation pathway . Negative_regulation TP63 IL12A 24047617 2888222 [p40] *inhibition* ameliorates Alzheimer 's disease associated neuropathology and spatial memory in SAMP8 mice . Negative_regulation TP63 IL12B 24047617 2888223 [p40] *inhibition* ameliorates Alzheimer 's disease associated neuropathology and spatial memory in SAMP8 mice . Negative_regulation TP63 KLF1 14976188 1235972 Activation and *repression* of interleukin-12 [p40] transcription by erythroid in macrophages . Negative_regulation TP63 KLF10 14976188 1235963 Activation and *repression* of interleukin-12 [p40] transcription by erythroid in macrophages . Negative_regulation TP63 KLF11 14976188 1235964 Activation and *repression* of interleukin-12 [p40] transcription by erythroid in macrophages . Negative_regulation TP63 KLF12 14976188 1235973 Activation and *repression* of interleukin-12 [p40] transcription by erythroid in macrophages . Negative_regulation TP63 KLF13 14976188 1235965 Activation and *repression* of interleukin-12 [p40] transcription by erythroid in macrophages . Negative_regulation TP63 KLF14 14976188 1235971 Activation and *repression* of interleukin-12 [p40] transcription by erythroid in macrophages . Negative_regulation TP63 KLF15 14976188 1235966 Activation and *repression* of interleukin-12 [p40] transcription by erythroid in macrophages . Negative_regulation TP63 KLF16 14976188 1235968 Activation and *repression* of interleukin-12 [p40] transcription by erythroid in macrophages . Negative_regulation TP63 KLF17 14976188 1235969 Activation and *repression* of interleukin-12 [p40] transcription by erythroid in macrophages . Negative_regulation TP63 KLF2 14976188 1235974 Activation and *repression* of interleukin-12 [p40] transcription by erythroid in macrophages . Negative_regulation TP63 KLF3 14976188 1235967 Activation and *repression* of interleukin-12 [p40] transcription by erythroid in macrophages . Negative_regulation TP63 KLF4 14976188 1235975 Activation and *repression* of interleukin-12 [p40] transcription by erythroid in macrophages . Negative_regulation TP63 KLF5 14976188 1235976 Activation and *repression* of interleukin-12 [p40] transcription by erythroid in macrophages . Negative_regulation TP63 KLF6 14976188 1235970 Activation and *repression* of interleukin-12 [p40] transcription by erythroid in macrophages . Negative_regulation TP63 KLF7 14976188 1235977 Activation and *repression* of interleukin-12 [p40] transcription by erythroid in macrophages . Negative_regulation TP63 KLF8 14976188 1235978 Activation and *repression* of interleukin-12 [p40] transcription by erythroid in macrophages . Negative_regulation TP63 KLF9 14976188 1235962 Activation and *repression* of interleukin-12 [p40] transcription by erythroid in macrophages . Negative_regulation TP63 MAP3K11 24790140 2944605 Furthermore , deficiency *increased* the activation of [p63Rho] guanine nucleotide exchange factor , RhoA , and Rho kinase in VSMC , a pathway known to promote neointimal hyperplasia , and reconstitution of MLK3 expression attenuated Rho kinase activation . Negative_regulation TP63 MAP3K11 24790140 2944611 We demonstrate that limits RhoA activation and injury induced neointima formation by binding to and *inhibiting* the activation of [p63Rho] guanine nucleotide exchange factor , a RhoA activator . Negative_regulation TP63 MDM2 11223036 787818 Here we show that the transcriptional activities of p53 and p73 , but not that of [p63] , were *inhibited* by both and MDMX . Negative_regulation TP63 MDM2 11714701 896990 Overexpression of *increased* the steady-state level of intracellular [p63] and enhanced its transcriptional activity . Negative_regulation TP63 MYLIP 18311128 1879113 We show that directly *represses* the expression of [p63] : it fails to switch off suprabasally when either Dicer1 or miR-203 is absent and it becomes repressed basally when miR-203 is prematurely expressed . Negative_regulation TP63 MYLIP 24398967 2900288 Moreover microRNA target search algorithms and experimental strategies suggested that *suppressed* [TP63] expression as a novel target of miR-301b . Negative_regulation TP63 MYLIP 24398967 2900289 In summary , overexpressed may *suppress* [TP63] expression and contributes to promote cell invasiveness and to enhance gemcitabine resistance in pancreatic carcinoma cells . Negative_regulation TP63 NA 17498688 1821956 Interestingly , the up-regulation of [p63] was totally *suppressed* by , but not by dexamethasone or pirfenidone . Negative_regulation TP63 NAB1 19812204 2154346 Similarly , also *inhibited* fibrillar amyloid beta ( Abeta ) - , prion peptide- , double stranded RNA ( polyinosinic-polycytidylic acid ) - , HIV-1 Tat- , 1-methyl-4-phenylpyridinium ( + ) - , IL-1beta- , and IL-12 [p40] ( 2 ) -induced microglial expression of iNOS . Negative_regulation TP63 NAB2 19812204 2154347 Similarly , also *inhibited* fibrillar amyloid beta ( Abeta ) - , prion peptide- , double stranded RNA ( polyinosinic-polycytidylic acid ) - , HIV-1 Tat- , 1-methyl-4-phenylpyridinium ( + ) - , IL-1beta- , and IL-12 [p40] ( 2 ) -induced microglial expression of iNOS . Negative_regulation TP63 NOTCH1 16618808 1551169 Here we show that [p63] expression is *suppressed* by activation in both mouse and human keratinocytes through a mechanism independent of cell cycle withdrawal and requiring down-modulation of selected interferon-responsive genes , including IRF7 and/or IRF3 . Negative_regulation TP63 NQO1 22249251 2681226 Previously , we have shown a *role* of cytosolic ( NQO1 ) in the stabilization of [p63] against 20S proteasomal degradation resulting in thinning of the epithelium and chemical induced skin cancer ( Oncogene ( 2011 ) 30 , 1098-1107 ) . Negative_regulation TP63 PIK3CA 23545251 2763006 In addition , KGFR induced a ligand dependent decrease of [p63] through a miR-203 independent mechanism and this effect was *blocked* by inhibition of the signaling , which is the main pathway involved in KGFR dependent keratinocyte differentiation , suggesting that alterations of the KGFR/p63 crosstalk are responsible for the impairment of keratinocyte differentiation induced by 16E5 and that the opposite tumor-suppressive action of KGFR and oncogenic role of E5 might both involve p63 . Negative_regulation TP63 PIK3R1 23545251 2763007 In addition , KGFR induced a ligand dependent decrease of [p63] through a miR-203 independent mechanism and this effect was *blocked* by inhibition of the signaling , which is the main pathway involved in KGFR dependent keratinocyte differentiation , suggesting that alterations of the KGFR/p63 crosstalk are responsible for the impairment of keratinocyte differentiation induced by 16E5 and that the opposite tumor-suppressive action of KGFR and oncogenic role of E5 might both involve p63 . Negative_regulation TP63 PVR 19011627 2016722 The binding of to TIGIT on human dendritic cells enhanced the production of interleukin 10 and *diminished* the production of interleukin [12p40] . Negative_regulation TP63 RELA 24127607 2858996 ASPP2 suppresses squamous cell carcinoma via *mediated* repression of [p63] . Negative_regulation TP63 RHOA 24790140 2944610 We demonstrate that MLK3 limits activation and injury induced neointima formation by binding to and *inhibiting* the activation of [p63Rho] guanine nucleotide exchange factor , a RhoA activator . Negative_regulation TP63 SYT1 16862183 1682270 also *suppressed* the expression of [p63] and the putative breast epithelial progenitor marker cytokeratin 5/6 . Negative_regulation TP63 SYT1 24127607 2858995 ASPP2 suppresses squamous cell carcinoma via *mediated* repression of [p63] . Negative_regulation TP63 TP53 10373484 622592 In vivo co-transfection assays of the ability of p53 and its homologues to activate reporter genes showed that a DNA binding mutant of was not able to act in a dominant negative manner over wild-type p73 or p63 but that a p73 mutant could *inhibit* the activity of wild-type [p63] . Negative_regulation TP63 TP53 16331262 1539514 Here , we present data indicating that , prolonged loss of *leads* to the activation of a p53 independent mechanism for transcriptional regulation of [DeltaN-p63] . Negative_regulation TP63 TP53 22949650 2672657 mutants *inhibit* expression of both [p63] and miR-205 , and the cell migration , in a cell line expressing endogenous mutated p53 , can be abrogated by pre-miR-205 or silencing of mutated p53 . Negative_regulation TP63 USO1 16331262 1539516 Finally , we present evidence that disruption of expression *leads* to decreased expression of [DeltaN-p63] and that overexpression of TA-p63-gamma was sufficient to enhance the activity of the DeltaN-p63 promoter . Negative_regulation TP63 USO1 21930934 2492189 Consistent with this , iASPP bound [p63] and *inhibited* the transcriptional activity of both and ?Np63a in vitro and influenced the expression level of p63 regulated genes such as loricrin and involucrin in vivo . Negative_regulation TP63 VDR 17274004 1697398 In transfection experiments , the presence of the shorter *resulted* in higher NF-kappaB- and NFAT-driven transcription as well as higher [IL-12p40] promoter-driven transcription . Negative_regulation TPH1 TNF 24337018 2895114 PCPA markedly attenuated MCT induced pulmonary vascular remodeling and lung inflammation , *inhibited* the expression of [Tph-1] and SERT and suppressed the expression of MMP-2/-9 , TIMP-1/-2 , interleukin-1ß (IL-1ß) , and intercellular adhesion molecule-1 ( ICAM-1 ) . Negative_regulation TPM1 CA12 11804617 903264 The results of this study support the concept that inhibition of in neurons *contributes* to the anticonvulsant activity of [TPM] . Negative_regulation TPM1 TMOD1 7798317 281065 In the absence of [tropomyosin] , *acts* as a `` leaky '' cap , partially inhibiting elongation and depolymerization at the pointed filament ends ( Kd for inhibition of elongation = 0.1-0.4 microM ) . Negative_regulation TPM2 CA12 11804617 903277 The results of this study support the concept that inhibition of in neurons *contributes* to the anticonvulsant activity of [TPM] . Negative_regulation TPM2 TMOD1 7798317 281069 In the absence of [tropomyosin] , *acts* as a `` leaky '' cap , partially inhibiting elongation and depolymerization at the pointed filament ends ( Kd for inhibition of elongation = 0.1-0.4 microM ) . Negative_regulation TPM3 CA12 11804617 903290 The results of this study support the concept that inhibition of in neurons *contributes* to the anticonvulsant activity of [TPM] . Negative_regulation TPM3 TMOD1 7798317 281073 In the absence of [tropomyosin] , *acts* as a `` leaky '' cap , partially inhibiting elongation and depolymerization at the pointed filament ends ( Kd for inhibition of elongation = 0.1-0.4 microM ) . Negative_regulation TPM4 CA12 11804617 903303 The results of this study support the concept that inhibition of in neurons *contributes* to the anticonvulsant activity of [TPM] . Negative_regulation TPM4 TMOD1 7798317 281077 In the absence of [tropomyosin] , *acts* as a `` leaky '' cap , partially inhibiting elongation and depolymerization at the pointed filament ends ( Kd for inhibition of elongation = 0.1-0.4 microM ) . Negative_regulation TRAF2 FAS 10229103 610955 Nonetheless , a functional link between TRAF2 and IKK activity in B cells is demonstrated by the fact that overexpression of [TRAF2] constitutively *induces* IKK activity , NF-kappaB luciferase and expression . Negative_regulation TRAF2 TNF 15122760 1242260 CPT treatment completely abrogated the induced NF-kappa B activation , and mRNA expression of the antiapoptotic factors [TNF-receptor associated factor 2] , FLICE-inhibitory protein , and X-linked inhibitor of apoptosis protein was also *inhibited* by CPT. The caspase inhibitors benzyloxycarbonyl-Val-Ala-Asp- ( OMe ) -fluoromethylketone ( zVAD-fmk ) and benzyloxycarbonyl-Asp ( OMe ) -Glu ( OMe ) -Val-Asp ( OMe ) -chloromethylketone ( zDEVD-fmk ) , as well as depletion of intracellular ATP by fructose prevented CPT/TNF induced apoptosis . Negative_regulation TRAF3 RNASE1 10087233 599798 Those against PB1 and PB2 inhibited the cap-I dependent activity , but those against PB2 alone slightly *inhibited* the [cap-I] binding activity . Negative_regulation TRAF3 RNASE7 10087233 599806 Those against PB1 and PB2 inhibited the cap-I dependent activity , but those against PB2 alone slightly *inhibited* the [cap-I] binding activity . Negative_regulation TRAF6 FOXO1 20228261 2254410 IGF-1 prevents ANG II-induced skeletal muscle atrophy via Akt- and dependent *inhibition* of the [ubiquitin ligase] atrogin-1 expression . Negative_regulation TRAF6 TLR7 22033459 2547584 Here we found that stimulation of J774.1 cells with various ligands *led* to decreases in [TRAF6] protein levels that occurred at a slower rate than I?Ba degradation . Negative_regulation TRAF6 TLR7 24384074 2900082 *led* to a down-regulation of MARCH1 [ubiquitin ligase] which prevents the degradation of MHC-II and decreased IL-10 also contributed to an increase in MHC-II . Negative_regulation TRAF6 TNF 19411063 2070925 Wu et al. , in this issue of Cancer Cell , show that dependent NFkappaB activation *induces* COP9 signalosome mediated inhibition of GSK3beta and the SCF(beta-TRCP) [ubiquitin ligase] , thus leading to stabilization of the transcription factor Snail and promoting cell migration and metastasis . Negative_regulation TRIB3 FOXO1 17303659 1725970 PKB activation can not be accounted for by a Foxo1 mediated increase in upstream signaling components such as insulin receptor substrate 1 or 2 or by *mediated* down-regulation of [Tribbles homolog 3] . Negative_regulation TRIM54 FOXO1 19553561 2128951 activation *resulted* in a significant increase in muscle atrophy F-box (MAFbx)/atrogin-1 , [muscle-specific RING finger protein] 1 ( MuRF-1 ) , and Bcl-2 interacting mediator of cell death ( Bim ) gene expression , with no significant increase in Bcl-2/adenovirus E1B 19-kDa interacting protein 3 ( BNip3 ) gene expression . Negative_regulation TRIM63 FBXO32 23746953 2819993 To investigate the possible mechanism , MuRF1 and was subjected to Western blot analysis and expression of [MURF1] was *inhibited* in gastrocnemius muscle . Negative_regulation TRIM63 FBXO32 23866982 2839183 Suppression of *resulted* in increased expression of [MuRF1] and vice versa , suggesting that the ubiquitin ligases are regulated by compensatory mechanisms . Negative_regulation TRIM63 PGC 20647557 2322082 Recent studies suggest that muscle atrophy caused by denervation is associated with reduced expression of the nuclear cofactor peroxisome proliferator activated receptor-? coactivator ( PGC ) -1ß and that may be a *repressor* of the atrogin-1 and [MuRF1] genes . Negative_regulation TRNAE1 IL1B 8872964 389789 Unexpectedly , the inhibitory action of PKA was not through cAMP response element ( CRE ) but through TRE , because ( i ) activation of CRE was not induced by , and ( ii ) cAMP mediated activation of PKA *suppressed* the basal [TRE] activity . Negative_regulation TRNAE1 TGM2 9582307 503897 The results of these experiments suggest that TGF-beta1 , BMP2 , and BMP4 regulation of mouse gene expression *requires* a composite [TRE] located in the 5'-flanking DNA . Negative_regulation TRPC1 ANGPT1 15920022 1420477 In immunoprecipitation studies , *inhibited* the association of IP3 receptor ( IP3R ) and [TRPC1] , consistent with the coupling hypothesis of Ca2+ entry . Negative_regulation TRPC6 TNF 23525112 2777345 In cultured human mesangial cells , H2O2 and *inhibited* [TRPC6] mRNA expression in a time dependent manner . Negative_regulation TSC22D3 EPHB2 16216878 1483500 In Xenopus oocytes with activated ERK , heterologous [GILZ] expression consistently *inhibited* expression and markedly stimulated ENaC mediated Na+ current , in a manner similar to that of U0126 ( a pharmacologic inhibitor of ERK signaling ) . Negative_regulation TSC22D3 TLR7 22539300 2590200 We found that activation *reduced* [GILZ] mRNA stability , which was mediated via the GILZ 3'-untranslated region . Negative_regulation TSLP TNF 20228393 2237580 IL-4 and or pregnancy associated hormones *result* in a significant increase in [TSLP] mRNA expression and protein release from EVT , and TSLP promotes primary EVT proliferation and invasion in vitro . Negative_regulation TSPAN1 CD81 15004227 1237041 Dynamic regulation of a [GPCR-tetraspanin-G] protein complex on intact cells : central *role* of in facilitating GPR56-Galpha q/11 association . Negative_regulation TSPAN1 IGSF8 21609323 2450295 Functionally , the PIP interaction regulates the stability of EWI2 proteins , whereas palmitoylation is needed for [tetraspanin-EWI2] association and dependent *inhibition* of cell migration and lamellipodia formation . Negative_regulation TTC37 SPHK1 19036099 2022985 In particular , [SKI] *induced* an early , significant inhibition of activity , impaired cell cycle progression and triggered apoptosis in K562 cells . Negative_regulation TTN TNF 20373002 2282039 Pretreatment of these cells with MG132 , an inhibitor of nuclear factor kappa B (NF-kappaB) pathway , abolished *induced* reduction in mRNA levels of dystrophin and [titin] . Negative_regulation TUFM FAS 20212524 2223111 We validated experimentally that stimulation *resulted* in an interaction of [p43-FLIP] with the IKK complex followed by its activation . Negative_regulation TWIST1 EPHB2 17909010 1803494 [TWIST] expression is *suppressed* by EGFR and Janus activated kinase (JAK)/signal transducer and activator of transcription 3 ( STAT3 ) inhibitors , but not significantly by those targeting phosphoinositide-3 kinase and . Negative_regulation TWIST1 MAP2K6 17909010 1803500 [TWIST] expression is *suppressed* by EGFR and Janus activated kinase (JAK)/signal transducer and activator of transcription 3 ( STAT3 ) inhibitors , but not significantly by those targeting phosphoinositide-3 kinase and . Negative_regulation TXN FOXO1 23803610 2824463 competes with carbohydrate response element binding protein ( ChREBP ) and *inhibits* [thioredoxin interacting protein (TXNIP)] transcription in pancreatic beta cells . Negative_regulation TXN TNF 15696199 1382716 In cultured ECs , reduction of TXNIP expression by small interfering RNA increased [TRX] binding to ASK1 and *inhibited* activation of JNK/p38 and VCAM1 expression . Negative_regulation TXN TNF 23085515 2713718 Furthermore , *prevented* the physical interaction between [thioredoxin-1] and MST1 and promoted the homodimerization and activation of MST1 . Negative_regulation TXNIP FOXO1 23803610 2824465 Moreover , *blocked* glucose induced [TXNIP] expression and reduced glucose induced ChREBP binding at the TXNIP promoter without affecting ChREBP expression or nuclear localization , suggesting that FOXO1 may compete with ChREBP for binding to the TXNIP promoter . Negative_regulation TXNIP FOXO1 23803610 2824466 Together , these results demonstrate that *inhibits* beta cell [TXNIP] transcription and suggest that FOXO1 confers this inhibition by interfering with ChREBP DNA binding at target gene promoters . Negative_regulation TYR ARSA 18175938 1856203 Interestingly , did not *inhibit* the catalytic activity of mushroom [tyrosinase] ( concentration range 0.5-4.0 mM ) . Negative_regulation TYR ARSA 18175938 1856204 *inhibited* [tyrosinase] expression in a dose dependent manner . Negative_regulation TYR EPHB2 16781122 1599360 These results suggest that hinokitiol induced phosphorylation *reduces* MITF and [TYR] transcription , and mediates the action of hinokitiol on melanogenesis . Negative_regulation TYR EPHB2 18478239 1951646 a inhibitor , PD98059 , almost completely *attenuated* the MbetaCD mediated inhibition of melanin synthesis and down-regulation of MITF and [tyrosinase] expression . Negative_regulation TYR EPHB2 21899547 2478220 The inhibitor *increased* [tyrosinase] activity and melanin production and reversed the acteoside induced decrease in tyrosinase activity and melanin content . Negative_regulation TYR EPHB2 23792203 2820533 Furthermore , a specific pathway inhibitor , PD98059 , blocked GGA induced melanin reduction and then *prevented* downregulation of MITF and [tyrosinase] by GGA . Negative_regulation TYR MAP2K6 15996858 1441289 Also , the inhibitor ( PD98059 ) in combination with nitro-derivatives *stimulated* an even greater increase in [tyrosinase] activity when compared to either drug . Negative_regulation TYR PDZK1 22696060 2681732 Overexpression of *increased* [tyrosinase] expression and melanosome transfer to keratinocytes , whereas PDZK1 knockdown reduced estrogen induced tyrosinase expression , through regulation of expression of estrogen receptors ( ERs ) ER-a and ER-ß . Negative_regulation TYR TGM2 8103799 228994 RA , ddRA , 4-hydroxy RA , 4-oxo RA and 5,6-epoxy RA ( 10-100 nM ) reduced epidermal activity in human keratinocytes to similar extents , and *inhibited* alpha-melanocyte stimulating hormone-isobutylmethylxanthine-inducible [tyrosinase] activity in Cloudman S-91 mouse melanoma cells by 67 , 39 , 48 , 51 and 19 % , respectively , at 100 nM . Negative_regulation TYR TNF 10102625 602271 First , we show that *inhibits* the activity and protein expression of [tyrosinase] which is the key enzyme of melanogenesis . Negative_regulation TYR TNF 19000188 1990881 Coccoloba uvifera L. showed antioxidant and [anti-tyrosinase] activities and also *inhibited* the production of IL-1alpha , and alpha-MSH in melanocytes subjected to UV radiation ( P < 0.01 ) . Negative_regulation TYR TNF 19782747 2183813 We found that a reduction in PKCdelta protein levels reversed the *mediated* reduction in insulin stimulated IRS-1 [Tyr] phosphorylation , Akt activation , and glycogen synthesis . Negative_regulation TYR TNF 8176258 255784 Previously we demonstrated that neonatal human melanocyte proliferation and [tyrosinase] activity are *inhibited* by interleukin-1 alpha , , and interleukin-6 . Negative_regulation TYRP1 ARSA 10889256 710421 Hairy root lines transformed with 35S-ASA2 grew in concentrations of up to 100 microM 5MT , whereas the controls were completely inhibited by 15 microM 5MT. Expression of the feedback-insensitive *resulted* in a 1.3- to 5.5-fold increase in free [Trp] . Negative_regulation UBE2V1 FOXO1 20228261 2254414 IGF-1 prevents ANG II-induced skeletal muscle atrophy via Akt- and dependent *inhibition* of the [ubiquitin ligase] atrogin-1 expression . Negative_regulation UBE2V1 TLR7 24384074 2900093 *led* to a down-regulation of MARCH1 [ubiquitin ligase] which prevents the degradation of MHC-II and decreased IL-10 also contributed to an increase in MHC-II . Negative_regulation UBE2V1 TNF 19411063 2070929 Wu et al. , in this issue of Cancer Cell , show that dependent NFkappaB activation *induces* COP9 signalosome mediated inhibition of GSK3beta and the SCF(beta-TRCP) [ubiquitin ligase] , thus leading to stabilization of the transcription factor Snail and promoting cell migration and metastasis . Negative_regulation UCP1 TNF 10884431 709571 The absence of both receptors or p55 receptor alone *resulted* in a significant reduction in brown adipocyte apoptosis and an increase in beta(3)-adrenoreceptor and [uncoupling protein-1] expression in obese mice . Negative_regulation UCP1 TNF 11277995 798104 *inhibits* [UCP-1] expression in brown adipocytes via ERKs . Negative_regulation UCP1 TNF 11277995 798105 activates extracellular regulated kinases ( ERKs ) and p38 mitogen activated protein kinase ( p38MAPK ) , and *inhibits* the expression of [uncoupling protein-1 (UCP-1)] and adipocyte-specific genes in rat fetal brown adipocytes . Negative_regulation UCP1 TNF 23302779 2769521 By using a luciferase reporter assay system , the conditioned medium and also *suppressed* the activity of the [UCP1] promoter and transcriptional factors binding to the cAMP response element ( CRE ) . Negative_regulation UCP2 FOXA1 23625627 2887244 *inhibits* the expression of [uncoupling protein 2] in hydrogen peroxide induced A549 cell line . Negative_regulation UCP2 FOXA1 23625627 2887245 Overexpression of FoxA1 by full-length complementary DNA reduced UCP2 expression , while silencing of expression by small interfering RNA significantly *increased* [UCP2] levels . Negative_regulation UCP2 FOXA1 23625627 2887248 These data indicate an important *role* of in regulating expression of [UCP2] . Negative_regulation UCP2 TNF 10685029 669824 Taken together , these results suggest that the upregulation of [UCP2] mRNA levels in the liver and WAT of ob/ob mice is not *due* to the lack of leptin , hyperphagia , increased tissue lipid content , or over-expression of . Negative_regulation UGCG TNF 8662965 367732 The addition of inhibitors for nuclear factor kappaB (NF-kappaB) to the cells caused a loss of the [gamma-GCS] mRNA expression in *response* to . Negative_regulation UGT1A6 ASIP 10049505 592638 The *role* of in [UGT1A6] was investigated by comparing some properties of UGT mutant proteins that have a single mutation ( D446K , D446E , D446N , D446Q , D446A , and D446T ) . Negative_regulation UGT1A6 PRKCD 20196639 2237014 *Role* for in the functional activity of human [UGT1A6] : implications for drug-drug interactions between PKC inhibitors and UGT1A6 . Negative_regulation ULBP2 EPHB2 19048119 1999268 Furthermore , overexpression of constitutively active in H9 parental cells *resulted* in increased [ULBP-2/ULBP-3] expression and enhanced NK cell lysis . Negative_regulation ULBP2 EPHB2 23308050 2712563 Furthermore , overexpression of constitutively active in ARK *resulted* in increased MICA/B and [ULBP2] expressions and enhanced NK cell lysis . Negative_regulation ULBP3 EPHB2 19048119 1999269 Furthermore , overexpression of constitutively active in H9 parental cells *resulted* in increased [ULBP-2/ULBP-3] expression and enhanced NK cell lysis . Negative_regulation ULK1 CCND1 21933914 2532724 The reduction of and phosphoretinoblastoma ( Rb ) protein expression *contributed* to arrest [at G(1)-phase] of the cell cycle . Negative_regulation UMOD HSD11B2 8969942 402761 These results show that both 3 [alpha,5B-THP] and CDCA are hypertensinogenic in the rat and that the inhibition of either <11 beta-HSD2> or 11 beta-HSD1 activity by endogenous progesterone metabolites and CDCA may be *involved* in the pathology of hypertension . Negative_regulation UMOD TNF 18303186 1873571 *Role* of and extracellular ATP in [THP-1] cell activation following allergen exposure . Negative_regulation UNC5B NTN1 23651544 2805308 In addition , significantly *inhibited* CoCl2 induced p53 stability and [UNC5B] expression and CoCl2 induced caspase-3 activity and cell death . Negative_regulation UNC5B TCF12 23599441 2783811 These responses are abrogated by inhibiting hypoxia-inducible transcription factor ( HIF)-1a , indicating a causal *role* for this in regulating Ntn1 and [Unc5b] expression in macrophages . Negative_regulation UNC5B TCF15 23599441 2783812 These responses are abrogated by inhibiting hypoxia-inducible transcription factor ( HIF)-1a , indicating a causal *role* for this in regulating Ntn1 and [Unc5b] expression in macrophages . Negative_regulation UNC5B TCF19 23599441 2783813 These responses are abrogated by inhibiting hypoxia-inducible transcription factor ( HIF)-1a , indicating a causal *role* for this in regulating Ntn1 and [Unc5b] expression in macrophages . Negative_regulation UNC5B TCF20 23599441 2783814 These responses are abrogated by inhibiting hypoxia-inducible transcription factor ( HIF)-1a , indicating a causal *role* for this in regulating Ntn1 and [Unc5b] expression in macrophages . Negative_regulation UNC5B TCF21 23599441 2783815 These responses are abrogated by inhibiting hypoxia-inducible transcription factor ( HIF)-1a , indicating a causal *role* for this in regulating Ntn1 and [Unc5b] expression in macrophages . Negative_regulation UNC5B TCF23 23599441 2783819 These responses are abrogated by inhibiting hypoxia-inducible transcription factor ( HIF)-1a , indicating a causal *role* for this in regulating Ntn1 and [Unc5b] expression in macrophages . Negative_regulation UNC5B TCF24 23599441 2783821 These responses are abrogated by inhibiting hypoxia-inducible transcription factor ( HIF)-1a , indicating a causal *role* for this in regulating Ntn1 and [Unc5b] expression in macrophages . Negative_regulation UNC5B TCF25 23599441 2783820 These responses are abrogated by inhibiting hypoxia-inducible transcription factor ( HIF)-1a , indicating a causal *role* for this in regulating Ntn1 and [Unc5b] expression in macrophages . Negative_regulation UNC5B TCF3 23599441 2783816 These responses are abrogated by inhibiting hypoxia-inducible transcription factor ( HIF)-1a , indicating a causal *role* for this in regulating Ntn1 and [Unc5b] expression in macrophages . Negative_regulation UNC5B TCF4 23599441 2783817 These responses are abrogated by inhibiting hypoxia-inducible transcription factor ( HIF)-1a , indicating a causal *role* for this in regulating Ntn1 and [Unc5b] expression in macrophages . Negative_regulation UNC5B TCF7 23599441 2783818 These responses are abrogated by inhibiting hypoxia-inducible transcription factor ( HIF)-1a , indicating a causal *role* for this in regulating Ntn1 and [Unc5b] expression in macrophages . Negative_regulation UNC5B TP53 23651544 2805304 The downregulation of expression with specific small interfering RNA ( p53 siRNA ) in CoCl2 treated PC12 cells *caused* reduction in apoptosis , [UNC5B] expression , and p21 expression . Negative_regulation UPF1 TNF 2226778 144487 Stability studies of IL-6 transcripts in fibroblasts showed that *delayed* IL-6 [mRNA decay] but not LT . Negative_regulation UPF2 TNF 2226778 144480 Stability studies of IL-6 transcripts in fibroblasts showed that *delayed* IL-6 [mRNA decay] but not LT . Negative_regulation UPF3B TNF 2226778 144482 Stability studies of IL-6 transcripts in fibroblasts showed that *delayed* IL-6 [mRNA decay] but not LT . Negative_regulation USF2 CCND1 19089909 2030998 It also inhibited the transcriptional activities of beta-catenin/TCF4 , and [USF2] , and *inhibited* the expression of endogenous and TGFbeta2 . Negative_regulation USF2 ID1 21921026 2511335 *inhibits* [USF2] and blocks TGF-ß induced apoptosis in mesangial cells . Negative_regulation USO1 TP63 21930934 2492190 Consistent with this , iASPP bound and *inhibited* the transcriptional activity of both [TAp63a] and ?Np63a in vitro and influenced the expression level of p63 regulated genes such as loricrin and involucrin in vivo . Negative_regulation USP1 CCND1 19711357 2145120 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP10 CCND1 19711357 2145121 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP11 CCND1 19711357 2145122 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP12 CCND1 19711357 2145214 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP13 CCND1 19711357 2145123 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP14 CCND1 19711357 2145124 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP15 CCND1 19711357 2145125 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP16 CCND1 19711357 2145126 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP18 CCND1 19711357 2145127 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP19 CCND1 19711357 2145128 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP2 CCND1 19711357 2145129 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP20 CCND1 19711357 2145130 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP21 CCND1 19711357 2145131 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP22 CCND1 19711357 2145132 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP24 CCND1 19711357 2145133 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP25 CCND1 19711357 2145134 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP26 CCND1 19711357 2145142 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP28 CCND1 19711357 2145135 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP29 CCND1 19711357 2145193 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP3 CCND1 19711357 2145136 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP30 CCND1 19711357 2145201 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP31 CCND1 19711357 2145196 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP32 CCND1 19711357 2145194 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP33 CCND1 19711357 2145195 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP34 CCND1 19711357 2145202 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP35 CCND1 19711357 2145197 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP36 CCND1 19711357 2145198 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP37 CCND1 19711357 2145199 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP38 CCND1 19711357 2145203 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP39 CCND1 19711357 2145207 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP4 CCND1 19711357 2145137 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP40 CCND1 19711357 2145205 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP41 CCND1 19711357 2145206 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP42 CCND1 19711357 2145204 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP43 CCND1 19711357 2145208 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP44 CCND1 19711357 2145200 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP45 CCND1 19711357 2145213 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP46 CCND1 19711357 2145209 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP47 CCND1 19711357 2145210 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP48 CCND1 19711357 2145192 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP49 CCND1 19711357 2145211 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP5 CCND1 19711357 2145138 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP50 CCND1 19711357 2145212 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP51 CCND1 19711357 2145215 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP53 CCND1 19711357 2145217 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP54 CCND1 19711357 2145216 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP6 CCND1 19711357 2145139 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP7 CCND1 19711357 2145140 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation USP8 CCND1 19711357 2145141 EcR , but not [Usp] reduces cyclin D1 expression and cyclin D1 concentration is *impaired* by . Negative_regulation UTRN CAPN8 15871680 1405678 Since [utrophin] was shown to be a natural substrate of calpain and known inhibitors of in cultured mdx myotubes *increased* utrophin levels , the above results were consistent with the following conclusions : ( 1 ) extrasynaptic utrophin increase is mainly responsible for the antidystrophic effect ; Negative_regulation VASP TNF 22320863 2617623 In addition , we confirmed that HIF-1a mediated the *repression* of [VASP] expression by in MCF-7 cells . Negative_regulation VCAM1 ARSA 20877628 2326511 High dose , but not NCX 4016 , *inhibited* endothelial cell expression of [VCAM-1] and thrombomodulin in the carotid arteries at 4 weeks after irradiation ; Negative_regulation VCAM1 EDN2 10206185 606481 It is conceivable that in human vascular endothelial cells , stimulation of an receptor results in the production of nitric oxide ( NO ) , *suppressing* the expression of [VCAM-1] . Negative_regulation VCAM1 ITGB2 10807407 692183 The expression of CD11b and on neutrophils and neutrophil dependent adhesion to endothelial cells elicited by HPE were inhibited by lansoprazole and omeprazole at clinical relevant doses , and the expression of ICAM-1 and [VCAM-1] on endothelial cells and endothelial dependent neutrophil adherence induced by IL-1beta were also *inhibited* by lansoprazole and omeprazole at similar doses . Negative_regulation VCAM1 MAP2K6 16734619 1566242 Interestingly , [VCAM-1] expression was *enhanced* by inhibitor ( PD98059 ) and c-Jun NH2-terminal kinase (JNK) inhibitor ( SP600125 ) . Negative_regulation VCAM1 MAP2K6 21631990 2437074 The reduction of [VCAM-1] , resulting from increased IL-8 , could be *blocked* by the inhibitor , PD98059 . Negative_regulation VCAM1 RCAN1 16627481 1583044 [Vascular cell adhesion molecule-1] was *inhibited* both by and I-kappaB at the level of mRNA , protein , promoter activity , and function ( monocyte adhesion ) . Negative_regulation VCAM1 SPHK1 15191888 1295213 We further investigated the *role* of in TNF-alpha induced expression of inflammatory genes , such as monocyte chemoattractant protein-1 ( MCP-1 ) and [VCAM-1] by using small interfering RNA ( siRNA ) specifically for SphK1 . Negative_regulation VCAM1 TNF 10734000 678597 We therefore investigated the *role* of in the expression and release of [vascular cell adhesion molecule-1] ( VCAM-1 ) in cultures of human cerebral endothelial cells ( HCEC ) in comparison with peripheral blood mononuclear cells ( PBMC ) . Negative_regulation VCAM1 TNF 11435740 832689 stimulation *resulted* in a 4-fold increase in ICAM-1 and [VCAM-1] expression . Negative_regulation VCAM1 TNF 11888521 920050 Inhibition of *induced* ICAM-1 , [VCAM-1] and E-selectin expression by selenium . Negative_regulation VCAM1 TNF 17909696 1824605 *reduced* ICAM-1- and [VCAM-1] expression and leukocyte infiltration to levels of non-diabetics and decreased macrophage residence by 3.3-fold compared with untreated diabetics . Negative_regulation VCAM1 TNF 17956026 1814777 Furthermore , and IL-4 , when added together , *induced* a synergistic effect on the secretion of [VCAM-1] and eotaxin . Negative_regulation VCAM1 TNF 18387509 1893180 Stimulation of human umbilical vein endothelial cells ( HUVECs ) with *resulted* in the increase of ICAM-1 and [VCAM-1] expressions , while pretreatment with the three components completely inhibited VCAM-1 expression in a dose dependent manner but had no effect on ICAM-1 expression . Negative_regulation VCAM1 TNF 19136606 2042715 In the cells cultured under a low-glucose condition when no increased HBP flux occurred , azaserine enhanced the manganese-superoxide dismutase ( MnSOD ) protein level and also inhibited the oxidative stress and the expression of [VCAM-1] and ICAM-1 in *response* to . Negative_regulation VCAM1 TNF 19627149 2180252 Stimulation of cells with increased ICAM-1 and VCAM-1 expression , and pretreatment with anthocyanins *inhibited* [VCAM-1] expression , but not ICAM-1 expression . Negative_regulation VCAM1 TNF 23085565 2703491 Stimulation of human umbilical vein endothelial cells ( HUVEC ) with increased ICAM-1 and VCAM-1 expressions , and the pretreatment with tanshinone IIA concentration dependently *inhibited* [VCAM-1] expression but not ICAM-1 expression . Negative_regulation VCAM1 TNF 7507414 244555 Interferon-gamma *induced* a weak increase in [VCAM-1] mRNA expression , with no synergistic effect on the stimulation by . Negative_regulation VCAM1 TNF 7692987 231207 partially *inhibited* the increase in [VCAM-1] and ICAM-1 expression , indicating that TNF in part mediates VCAM-1 and ICAM-1 expression . Negative_regulation VCAM1 TNF 7693840 234235 Of the neutralizing antibodies used against these cytokines , only could significantly *inhibit* [VCAM-1] and ICAM-1 expression . Negative_regulation VCAM1 TNF 8547644 346412 We have previously shown that [VCAM-1] expression is *induced* on human umbilical vein EC ( HUVEC ) by both tumor necrosis factor alpha (TNF-alpha) and interleukin-1 alpha (IL-1 alpha) , whereas on human dermal microvascular EC ( HDMEC ) only results in VCAM-1 expression . Negative_regulation VCAM1 TNF 8596155 342149 PUVA led to significant dose dependent decreases in the expression of [VCAM-1] and E-selectin that had been *induced* with before PUVA treatment . Negative_regulation VCAM1 TNF 8792802 381021 In addition , Et-1 *enhanced* significantly the IL-1 beta mediated upregulation of [VCAM-1] expression , whereas mediated expression of VCAM-1 was downregulated by Et-1 . Negative_regulation VCAN MUC16 16162137 1456117 Similarly , the binding of rNVLP to [PGM] could be *inhibited* effectively by HBGA in human saliva , and by Lewis b and Lewis d synthetic oligosaccharides ( OS ) , but not inhibited effectively by an H3 OS or by purified bovine submaxillary gland . Negative_regulation VCL CAPN8 16723743 1565529 In the present work , we show that inhibition of in primary mouse dendritic cells *leads* to enhanced accumulation of actin filaments , the Wiskott Aldrich Syndrome protein (WASP) , beta ( 2 ) integrins , talin , paxillin and [vinculin] in podosomes . Negative_regulation VDR CYP24A1 15955619 1452283 inhibition by genistein *increased* the half-life of 1,25 ( OH ) 2D3 thereby augmenting the homologous up-regulation of the [vitamin D receptor (VDR)] both at the mRNA and protein levels . Negative_regulation VDR EPHB2 15331595 1323253 Inhibition of activation by the MEK inhibitor , U0126 , *stimulated* [VDR] activity in MC3T3-E1 cells , but inhibited the activity in MG-63 cells as well as in HeLa cells . Negative_regulation VDR EPHB2 15331595 1323254 In cells in which RXRalpha is the VDR partner , the transcriptional activation of [VDR] by 1,25-D is *attenuated* by the concomitant activation of . Negative_regulation VDR HRH1 17547532 1784221 Overexpression of [VDR] in MG-63 osteosarcoma cells *induced* the expression of and DPT . Negative_regulation VDR IFI27 12771291 1094728 Parathyroid cell growth in patients with advanced secondary hyperparathyroidism : [vitamin D receptor] and cyclin dependent kinase *inhibitors* , p21 and . Negative_regulation VDR IL1B 8227347 235647 Furthermore , *suppressed* increase in cell size and the syntheses of [1,25-dihydroxyvitamin D3 receptor] and type X collagen , other markers of hypertrophy , but had little effect on the synthesis of total protein including type II collagen . Negative_regulation VDR TNF 20237236 2259887 In the present investigation , we identified that selectively *represses* activity of RAR but not [VDR] . Negative_regulation VDR TNF 22182686 2543316 This effect is mediated by the [VDR] and might *involve* direct inhibition of . Negative_regulation VDR TNF 22791341 2676547 In cultured proximal tubular epithelial HK-2 cells , proinflammatory *inhibited* the expression of [VDR] in a dose- and time-dependant manner . Negative_regulation VDR TNF 22791341 2676552 These results indicate that the early loss of [VDR] in chronic kidney diseases was likely *mediated* by proinflammatory , which renders tubular cells susceptible to EMT . Negative_regulation VDR TNF 9723887 529271 Here we test the hypothesis that *induces* a nuclear inhibitor of [RXR/VDR] binding to DNA and that this inhibitor can have independent effects on RXR . Negative_regulation VDR TNF 9723887 529274 To determine if *induced* a nuclear inhibitor of [VDR] and RXR binding to DNA , nuclear extract was isolated from TNF treated receptor deficient COS cells and mixed with nuclear extract from ligand treated receptor replete COS cells . Negative_regulation VDR TNF 9723887 529275 We conclude that *activates* a nuclear inhibitor of [VDR] and RXR . Negative_regulation VDR TP63 16462763 1573925 Additionally , we demonstrate that a naturally occurring missense mutant , p63gamma ( R279H ) and p14 ( ARF ) , both act in a dominant negative manner to *inhibit* p63gamma mediated upregulation of [VDR] . Negative_regulation VEGFA ADAMTS1 18272597 1891228 Renal ischemia reperfusion inhibits VEGF expression and induces , a novel [VEGF] *inhibitor* . Negative_regulation VEGFA ADAMTS1 18272597 1891231 Microarray analysis of angiogenesis related genes identified the enhanced expression of a number of genes , among these was ( a disintegrin and metalloproteinase with thrombospondin motif-1 ) , a secreted [VEGF] *inhibitor* . Negative_regulation VEGFA ANGPT1 12967476 1138876 In this system , which mimics angiogenesis in vivo , fibroblasts secrete a basal level of vascular endothelial growth factor ( [VEGF] ) , and *stimulated* tube formation . Negative_regulation VEGFA ANGPT1 15746084 1409702 Tie2 was expressed in the lymphatic endothelial cells and stimulation of these cells *resulted* in up-regulation of [vascular endothelial growth factor] receptor 3 ( VEGFR-3 ) . Negative_regulation VEGFA ANGPT1 16814127 1580791 The increase of [VEGF] induced by ang II was suppressed by losartan , and the increase of induced by ang II was *inhibited* by PD123319 as detected by immunoblot . Negative_regulation VEGFA ANGPT1 21704211 2447101 The results showed that NECA treatment triggered down-regulation of , *induced* [VEGF-189] expression , and stimulated neovascularization , highlighting the beneficial effect of NECA on the process of angiogenesis . Negative_regulation VEGFA ANGPT1 22558265 2591219 Overexpression of *led* to significant increases in number of CD31 ( + ) and smooth muscle-like cells and [VEGF] expression in bone marrow ( BM ) . Negative_regulation VEGFA ANGPT1 22596210 2643461 IL-6 not only enhances [VEGF] expression but also *inhibits* signalling by directly down regulating Ang-1 expression and up-regulating Ang-2 , an antagonist of Ang-1 . Negative_regulation VEGFA ARSA 18544566 1952216 The expression of vascular endothelial growth factor ( [VEGF] ) was significantly reduced in *response* to , with the p- isomer being more potent than the m- . Negative_regulation VEGFA ARSA 21826202 2463189 Consistent with these results , [VEGF] expression was lesser in AsA20CM compared to CCM , and indeed strongly *inhibited* VEGF level ( both cellular and secreted ) in glioma cells . Negative_regulation VEGFA CTGF 12114504 984808 These results demonstrate for the first time that is a substrate of MMPs and that the angiogenic activity of [VEGF] ( 165 ) suppressed by the complex formation with CTGF is *recovered* through the selective degradation of CTGF by MMPs . Negative_regulation VEGFA EDN2 23614848 2774836 Apelin is an adipokine that elicits endothelium dependent vasorelaxation and reduces arterial blood pressure , while relaxin is a protein hormone that induces the production of nitric oxide and [vascular endothelial growth factor] and *inhibits* and angiotensin II . Negative_regulation VEGFA EPHB2 11171046 783704 Wortmannin partially inhibited [VEGF] stimulation of PGI ( 2 ) production , but did not *inhibit* VEGF induced activity . Negative_regulation VEGFA EPHB2 11694503 896374 Overexpression of DN and Ras *had* no effect on [VEGF] expression in these cells . Negative_regulation VEGFA EPHB2 16101130 1444127 R115777 +/- paclitaxel inhibited HDJ-2 farnesylation , up-regulated RhoB , transiently lowered ( P ) and ( P ) Akt/Akt , reduced Raf-1 and MEK and *inhibited* secretion of [VEGF] and MMP-1 . Negative_regulation VEGFA EPHB2 23869238 2817625 BBR also downregulated HIF-1a and [VEGF] expression and *inhibited* Akt and phosphorylation . Negative_regulation VEGFA EPHB2 24297449 2894591 Here , we report that SAHA was able to inhibit the proliferation of the LCC cell line NCI-H460 in a dose- and time dependent manner , induced cell apoptosis and G2/M cell cycle arrest , decreased AKT and phosphorylation , *inhibited* the expression of pro-angiogenic factors ( [VEGF] , HIF-1a ) in vitro , and suppressed tumor progression in an NCI-H460 cell nude mouse xenograft model in vivo . Negative_regulation VEGFA F2R 11956584 931207 The secretion of VEGF protein in glioma cells was stimulated by the agonist peptide and the induction of [VEGF] was significantly *blocked* by the thrombin inhibitor hirudin , indicating that the up-regulation of VEGF was mediated by the thrombin/thrombin receptor pathway . Negative_regulation VEGFA FAS 10475096 642707 The same effect was found with Fas-ligation , although at high concentrations *induced* no further increase , but even a decrease of [VEGF] expression , possibly related to cell damage . Negative_regulation VEGFA FAS 15669079 1382137 Considering that Her-2/neu overexpression correlates with increased expression of the hypoxia inducible factor-1alpha ( HIF-1alpha ) , which , in a mitogen activated protein kinase (MAPK) dependent manner , plays a key role in the expression of several genes including cytokines such as vascular endothelial growth factor ( VEGF ) , we hypothesized that blockade should *result* in a concomitant down-regulation of [VEGF] . Negative_regulation VEGFA FAS 21729202 2452029 By real-time RT-PCR analysis , VEGF messenger RNA ( mRNA ) expression was found to significantly increase under hypoxia or treatment with desferrioxamine ( DFX ) , cobalt chloride ( CoCl ( 2 ) ) or even N-carbobenzoxyl-L-leucinyl-L-leucinyl-L-norvalinal ( MG-132 ) , while these increased [VEGF] mRNA expressions could also be *blocked* by or cis-element oligodeoxynucleotide ( dsODN ) transfection under hypoxia . Negative_regulation VEGFA FHL1 23086815 2690458 *inhibited* HIF1 transcriptional activity and HIF1 mediated [VEGF] expression in a hypoxia independent manner . Negative_regulation VEGFA GPR115 21724588 2466119 We report that a novel , GPR56 , *inhibits* [VEGF] production from the melanoma cell lines and impedes melanoma angiogenesis and growth , through the serine threonine proline-rich segment in its N-terminus and a signaling pathway involving protein kinase Ca . Negative_regulation VEGFA GPR132 21724588 2466108 We report that a novel , GPR56 , *inhibits* [VEGF] production from the melanoma cell lines and impedes melanoma angiogenesis and growth , through the serine threonine proline-rich segment in its N-terminus and a signaling pathway involving protein kinase Ca . Negative_regulation VEGFA GPR87 21724588 2466188 We report that a novel , GPR56 , *inhibits* [VEGF] production from the melanoma cell lines and impedes melanoma angiogenesis and growth , through the serine threonine proline-rich segment in its N-terminus and a signaling pathway involving protein kinase Ca . Negative_regulation VEGFA IL1B 15325633 1287168 In differentiated conditions and TNF-alpha , but not IL-17 , can *inhibit* the spontaneous secretion of [VEGF] by human OA , RA and FP chondrocytes , and IL-17 can restore the decrease in VEGF secretion caused by TNF-alpha . Negative_regulation VEGFA IL1B 16095117 1443667 [VEGF] production by osteoartritis ( OA ) chondrocytes was significantly *reduced* by while it was increased in the presence of TGFbeta . Negative_regulation VEGFA IL1B 16385078 1520069 Additionally , iNOS-deficient SMCs showed a low level of [VEGF] production in *response* to stimulation . Negative_regulation VEGFA IL1B 16888287 1672673 disturbed capillary development and *inhibited* the production of [vascular endothelial growth factor] in the lungs of infant mice . Negative_regulation VEGFA IL1B 16964394 1611535 Inhibitors of p38 MAPK and/or JNK significantly suppressed [VEGF] secretion both in the *presence* and absence of , while inhibitors of COX-2 , ERK1/2 , and PI3-K did not . Negative_regulation VEGFA IL1B 16964394 1611562 The levels of in U87MG were significantly higher than in other glioma cell lines , and IL-1 receptor antagonist *suppressed* basal secretion of [VEGF] from U87MG . Negative_regulation VEGFA IL1B 17525365 1762118 Furthermore , synergistically *enhanced* the effect of OSM on [VEGF] production . Negative_regulation VEGFA MAP2K6 16101130 1444136 R115777 +/- paclitaxel inhibited HDJ-2 farnesylation , up-regulated RhoB , transiently lowered ( P ) ERK/ERK and ( P ) Akt/Akt , reduced Raf-1 and and *inhibited* secretion of [VEGF] and MMP-1 . Negative_regulation VEGFA MAP2K6 19509115 2098326 Western blot analysis revealed that K-Ras activation promoted the phosphorylation of ( MEK1/2 ) and expression of c-Jun. MEK1/2 inhibitors , U0126 and PD98059 , significantly *inhibited* the secretion of both CXC chemokines and [VEGF] , whereas the c-Jun NH ( 2 ) -terminal kinase inhibitor SP600125 abrogated only CXC chemokine production . Negative_regulation VEGFA MMP28 12600446 1062252 Both [VEGF] blockade and *inhibition* reduce primary tumor size , metastasis , and angiogenesis , thereby increasing survival in experimental pancreatic cancer . Negative_regulation VEGFA MMP28 15604273 1346896 First , TIMP-2 can inhibit cell migration after [VEGF] *stimulation* by direct inhibition of activity induced in response to VEGF stimulation . Negative_regulation VEGFA MMP7 12600446 1062267 Both [VEGF] blockade and *inhibition* reduce primary tumor size , metastasis , and angiogenesis , thereby increasing survival in experimental pancreatic cancer . Negative_regulation VEGFA MMP7 15604273 1346911 First , TIMP-2 can inhibit cell migration after [VEGF] *stimulation* by direct inhibition of activity induced in response to VEGF stimulation . Negative_regulation VEGFA MMP7 17115023 1677211 We found statistically significant correlations between metastatic tumor spread and overexpression of , MMP10/2 , tissue *inhibitor* of metalloproteinase 3 , [vascular endothelial growth factor] ( VEGF ) , P38 , stromal NF-kappaB , and synaptophysin . Negative_regulation VEGFA PECAM1 15938647 1473444 With respect to the tumor vasculature , EGCG decreased the expression of , a cell surface marker of vascular endothelial cells , and *inhibited* the expression of [vascular endothelial growth factor] in tumors , which are essential for angiogenesis . Negative_regulation VEGFA PLAU 16474166 1548349 Moreover , Syk and Lck play differential roles in regulating Sp1 activation and expressions of melanoma cell adhesion molecule (MelCAM) , ( uPA ) , matrix metalloproteinase-9 (MMP-9) , and vascular endothelial growth factor ( VEGF ) in response to H/R. Overexpression of wild type Syk *inhibited* the H/R induced uPA , MMP-9 , and [VEGF] expression but up-regulated MelCAM expression . Negative_regulation VEGFA PLAU 19330806 2080411 Moreover , we found that as well as uPAR induced the production of VEGF and MMP-9 , and that the down-regulation of uPA/uPAR by siRNAs or B-DIM treatment *resulted* in the inhibition of [VEGF] and MMP-9 secretion which could be responsible for the observed inhibition of cell migration . Negative_regulation VEGFA PLAU 19693769 2150953 Our results , therefore , suggest that B-DIM down-regulates in aggressive breast cancers but in the absence of uPA-uPAR , B-DIM can directly *inhibit* [VEGF] and MMP-9 leading to the inhibition of cell growth and migration of breast cancer cells . Negative_regulation VEGFA S100A7 22189627 2624079 Moreover , the downregulation of by short hairpin RNA ( shRNA ) *led* to the reduced expression of vascular endothelial growth factor ( [VEGF] ) and inhibited tumor growth in vivo . Negative_regulation VEGFA S100B 21889514 2539102 In RAGE overexpressing myocytes , ( 100 nM ) *resulted* in increases in VEGF mRNA , [VEGF] protein , VEGF secretion , and activation of the transcription factor NF-?B . Negative_regulation VEGFA TCN1 18639543 1954649 Furthermore , *prevented* hypoxia induced expression of HIF-1 target genes for vascular endothelial growth factor ( [VEGF] ) and erythropoietin . Negative_regulation VEGFA TNF 10593330 572626 Lipopolysaccharide and stimulation *resulted* in significantly increased release of PMN [VEGF] ( 532+/-49 and 484+/-80 pg/mL , respectively ; for all , presented as mean +/- SEM ) compared with control experiments ( 32+/-4 pg/mL ) . Negative_regulation VEGFA TNF 10833366 697676 Culture of a first trimester trophoblast cell line ( HTR-8/SVneo ) , in the *presence* of either or TGF-beta1 , resulted in the expression of significant levels of [VEGF] in culture . Negative_regulation VEGFA TNF 11834522 911051 In addition , *attenuated* [vascular endothelial growth factor-] and epidermal growth factor induced extracellular signal regulated kinase phosphorylation , whereas overexpression of dominant negative SHP-1 prevented this inhibitory effect of TNF-alpha . Negative_regulation VEGFA TNF 12404274 1009776 also induced increased thyroglobulin secretion and *reduced* [VEGF] secretion by anaplastic tumor cells . Negative_regulation VEGFA TNF 12448828 1018242 Each of the berry samples studied significantly inhibited both H2O2 as well as *induced* [VEGF] expression by the human keratinocytes . Negative_regulation VEGFA TNF 12551841 1064173 We investigated whether blocking binding to its receptors would *inhibit* UV-induced [VEGF] expression and secretion in the keratinocyte derived line SCC-12F . Negative_regulation VEGFA TNF 15183452 1255970 Current our results indicate that upregulation of both TNF-alpha mRNA and protein expressions occur first in the inflammation induced by HD . [VEGF] upregulation *follows* the increased level of expression . Negative_regulation VEGFA TNF 15325633 1287166 In differentiated conditions IL-1beta and , but not IL-17 , can *inhibit* the spontaneous secretion of [VEGF] by human OA , RA and FP chondrocytes , and IL-17 can restore the decrease in VEGF secretion caused by TNF-alpha . Negative_regulation VEGFA TNF 16635740 1552734 On the protein level , melanin significantly induced and IL-6 protein production and *inhibited* [VEGF] production by monocytes and PBMC . Negative_regulation VEGFA TNF 20357262 2244979 Stimulation of macrophages with group X sPLA ( 2 ) in the presence of adenosine analogs induced a synergistic increase of [VEGF-A] release and *inhibited* production through a cooperation between A ( 2A ) and A ( 3 ) receptors . Negative_regulation VEGFA TP63 11971180 933601 These results suggest that is *involved* in the regulation of the [VEGF] gene expression and that modulation of VEGF expression by TAp63gamma and dNp63alpha is closely correlated with their distinct roles on the regulation of HIF1alpha stability . Negative_regulation VHLL MUC16 17215284 1709660 The [VLP] binding was partially inhibited by A- , H1- , or H2-specific monoclonal antibodies , but was completely *blocked* by porcine . Negative_regulation VIP MAOA 12605405 1062775 The deficiency *caused* an increase in AVP and [VIP] expression ( determined by immunohistochemistry , enzyme immunoassay , and in situ hybridization ) compared to C3H mice . Negative_regulation VLDLR IL1B 15808840 1391721 Use of specific pharmacologic inhibitors indicated that the tyrosine kinase inhibitors , herbimycin A and geldanamycin , completely reversed *induced* downregulation of the [VLDL receptor] expression . Negative_regulation VLDLR IL1B 15808840 1391722 In addition , the c-Src specific inhibitor PP2 or adenoviral mediated gene transfer of kinase inactive ( KI ) -c-Src failed to reverse *induced* downregulation of [VLDL receptor] expression . Negative_regulation VSNL1 EGF 22479362 2578858 Conversely , of VILIP-1 positive SCC cells *leads* to the down-regulation of [VILIP-1] and the induction of Snail1 expression . Negative_regulation VWF ARSA 3877338 53516 In spite of inhibiting platelet aggregation , EDTA , PGE1 and did not *prevent* platelet binding of IIB post-DDAVP [vWF] . Negative_regulation VWF C1QTNF1 16195328 1507783 completely or partially *prevented* [VWF] and GPVI-Fc4 binding to collagen , respectively . Negative_regulation VWF HES2 11395618 823331 Dextran , gelatin , and all can *induce* a specific decrease of [von Willebrand factor] and factor VIII : c. Blood coagulation is most impaired by dextran and high molecular weight HES , both associated with increased postoperative blood loss . Negative_regulation VWF PLAT 1653670 164674 3. Venous blood samples were taken before , during and after the procedure for assay of plasma vasopressin , adrenaline and noradrenaline concentrations , Factor VIII coagulant activity , [von Willebrand factor] antigen level , euglobulin clot lysis time , tissue-type plasminogen activator activity and *inhibition* . Negative_regulation VWF SELL 16102437 1444431 PCI *induced* significant increases of hsCRP in both groups as well as an increase in [vWf] in native atherosclerosis , whereas a decrease in was observed in native atherosclerosis . Negative_regulation WAS TNF 9718090 528147 WIN 55,212-2 and [delta9-THC] *induced* a concentration dependent decrease in level in the bronchoalveolar lavage fluid ( BALF ) ( maximum inhibition 52.7 % and 36.9 % for intranasal doses of 750 nmol x kg ( -1 ) and 2.65 mmol x kg ( -1 ) , respectively ) . Negative_regulation WDR61 ARSA 6711391 37376 These studies suggest that regulates PAF availability unrelated to its effect on cyclooxygenase and that MC membrane products directly *inhibit* [PAF] activity from rat PLC . Negative_regulation WDR61 ARSA 8430224 212742 Since acetylsalicylic acid (ASA) is an accepted therapeutic alternative in these patients , we sought to determine if would *attenuate* endothelial cell [PAF] production resulting from ACA exposure . Negative_regulation WDR61 CD14 7541418 310478 The soluble form of ( sCD14 ) , when added to MO stimulated with LBP-LPS complexes , *inhibited* the synthesis of [PAF] possibly by competing with mCD14 . Negative_regulation WDR61 IL1B 1519663 196904 Stimulation of isolated mouse alveolar macrophages with recombinant murine or IL-1 alpha *resulted* in rapid , dose dependent , and cell concentration dependent increases in [PAF] secretion . Negative_regulation WDR61 SPHK1 19036099 2022986 In particular , [SKI] *induced* an early , significant inhibition of activity , impaired cell cycle progression and triggered apoptosis in K562 cells . Negative_regulation WDR61 TNF 9403541 469611 Furthermore , inhibiting [PAF] production with AACOCF3 , or manoalide , also *inhibited* LPS induced Mphi mRNA expression . Negative_regulation WHSC1 MAP2K6 21163924 2390739 Reexpression of MAF rescued cells from death induced by [MMSET] depletion , *inhibition* , or FOS inactivation . Negative_regulation WIF1 DNMT3A 23939044 2835859 The three DNMTs were up-regulated in NSCLC tumor tissues and suppression of and DNMT3B *restored* the expression of [WIF-1] in NSCLC cells . Negative_regulation WIF1 DNMT3B 23939044 2835860 The three DNMTs were up-regulated in NSCLC tumor tissues and suppression of DNMT3A and *restored* the expression of [WIF-1] in NSCLC cells . Negative_regulation WIF1 MYLIP 21048943 2344512 Furthermore , over-expression of *diminished* SFRP1 , SFRP4 , and [WIF-1] , and increased Wnt-5a expression . Negative_regulation WIF1 SHH 19700758 2133291 Furthermore , BMP signaling stimulated [Wnt inhibitory factor-1] expression and promoter activity in cultured tumor cells and HaCaT keratinocytes , as well as *inhibited* expression , as compared with the corresponding controls . Negative_regulation WIF1 SP1 18701434 1979663 Using silencing RNA approaches , we confirmed that downregulation of *resulted* in an increased expression of [WIF1] and decreased methylation of WIF1 promoter . Negative_regulation WISP1 MMP28 19180479 2033071 Adenoviral overexpression of [WISP-1] in murine knee joints *induced* and aggrecanase expression and resulted in cartilage damage . Negative_regulation WISP1 MMP7 19180479 2033086 Adenoviral overexpression of [WISP-1] in murine knee joints *induced* and aggrecanase expression and resulted in cartilage damage . Negative_regulation WNK1 FAS 12934082 1132795 The total levels of p50 , p65 and IkappaBalpha remain unchanged , but the levels of phosphorylated IkappaBalpha and of nuclear [p65] increase , in *response* to . Negative_regulation WNK1 FOXO1 21940942 2507175 Deacetylated inhibits free cholesterol induced Akt phosphorylation and *increases* levels of the nuclear factor-?B precursor p105 , decreasing nuclear translocation of nuclear factor-?B [p65] subunit and dampening mitogen activated protein/extracellular signal regulated kinase activation to prevent inflammation . Negative_regulation WNK1 NEDD9 19278579 2046325 It was shown that RNAi targeting IKKalpha and IKKgamma could down-regulate the expression of IKKalpha and IKKgamma genes , and at the same time , down-regulate the expression of NF-KappaB p65 , p50 and proteins both in cytoplasm and nucleus , and *inhibit* the nuclear translocation of NF-KappaB [p65] , p50 and p105 proteins . Negative_regulation WNK1 TCN1 23936501 2826962 inhibits the phosphorylation and degradation of I?Ba and *blocks* the nuclear translocation of [p65] , and thus inhibits the expression of NF-?B target genes XIAP , cyclin D1 , and Bcl-xL . Negative_regulation WNK1 TLR7 18523248 1922739 SP-A decreases the phosphorylation of IkappaBalpha , a key regulator of NF-kappaB activity , and nuclear translocation of [p65] which result in diminished TNF-alpha secretion in *response* to ligands . Negative_regulation WNK1 TNF 11028545 739575 Incubation of cells in the NF-kappaB inhibitor PSI-I blocked LPS and induced *inhibition* of apoptosis ( P < 0.05 ) and the induction of both nuclear [p65] and TRAF-1 mRNA . Negative_regulation WNK1 TNF 12485424 1024922 Inhibition of *stimulated* [NFkappaB/p65] in human keratinocytes by alpha-melanocyte stimulating hormone and adrenocorticotropic hormone peptides . Negative_regulation WNK1 TNF 20564507 2345401 Moreover , HSYA decreased NF-?B [p65] nuclear translocation , *inhibited* proinflammatory cytokine , IL-1ß and IL-6 mRNA expression and promoted antiinflammatory cytokine IL-10 gene expression following LPS injection . Negative_regulation WNT1 ARSA 16282376 1484066 *inhibited* [Wnt] signaling by a dual mechanism : at low concentrations it blocked the formation of beta-catenin/Tcf complexes ( dominant mechanism ) , and at higher concentrations it also cleaved beta-catenin . Negative_regulation WNT1 AXIN2 15572025 1355624 Further , we show that can *repress* [Wnt] signalling leading to reduced cell growth and increased cell death . Negative_regulation WNT1 AXIN2 16881048 1625560 While Notch can regulate ectopic Wingless signalling caused by loss of function of Shaggy , it can only partially regulate the ectopic [Wnt] signalling *induced* by the loss of function . Negative_regulation WNT1 AXIN2 17373666 1741399 In this assay , *inhibited* [Wnt] signaling demonstrated in luciferase reporter assays . Negative_regulation WNT1 AXIN2 18632632 1937072 Transfection of C4-2B cells with , an *inhibitor* of canonical [Wnt] signaling , blocked Wnt3a but not Wnt5a induction of the BMP promoters . Negative_regulation WNT1 AXIN2 18951693 2014571 [Wnt] pathway *inhibitors* , ( intracellular ) or Dickkopf-1 ( extracellular ) blocked the regulation of VCAM-1 by diffusible Wnt3a . Negative_regulation WNT1 AXIN2 19581931 2122490 Both PP1 and bind to the N-terminus of Dab2 and a Dab2 truncation mutant consisting of the N-terminal phosphotyrosine binding domain blocks PP1-Axin interactions and *inhibits* [Wnt] signaling . Negative_regulation WNT1 AXIN2 19888210 2161322 We show that Ube2m interacts with and modulates beta-catenin stability , and that the antagonistic effect of Nkd1 on [Wnt] signaling *requires* interaction with , itself a negative pathway regulator . Negative_regulation WNT1 AXIN2 21555575 2435398 Tissue-specific *roles* of in the inhibition and activation of [Wnt] signaling in the mouse embryo . Negative_regulation WNT1 AXIN2 21555575 2435419 The results indicate that although increased stability of *leads* to a loss of canonical [Wnt] signaling in most tissues , stabilized Axin2 enhances Wnt pathway activity in a specific progenitor population in the late primitive streak . Negative_regulation WNT1 AXIN2 22322943 2592189 CDC20-resistant *inhibits* [Wnt] signalling and attenuates colony formation of colorectal cancer cells . Negative_regulation WNT1 AXIN2 22957046 2667730 Differential *role* of RGS domain function in [Wnt] signaling during anteroposterior patterning and maternal axis formation . Negative_regulation WNT1 AXIN2 22957046 2667825 This study was performed to test the hypothesis that RGS-Gna interactions would be *required* to attenuate [Wnt] signaling . Negative_regulation WNT1 AXIN2 9501208 491099 In mammalian cells , *inhibits* [Wnt-1] stimulation of beta-catenin/lymphoid enhancer factor 1-dependent transcription . Negative_regulation WNT1 AXIN2 9601641 506615 In a Xenopus developmental system , [Wnt-1] signaling was *inhibited* by , the product of the murine fused gene . Negative_regulation WNT1 CCND1 19544418 2128789 [Wnt1] expression was attenuated by Smad4 small interfering RNA ( siRNA ) , and BMP-4 induced expression was *inhibited* by Smad4 and Wnt1 siRNAs . Negative_regulation WNT1 CCND1 20856206 2381652 One of such molecules is V3Nter , a soluble SFRP-like frizzled polypeptide that binds to Wnt3a and *inhibits* [Wnt] signaling and expression of the ß-catenin target genes and c-myc. V3Nter is derived from the cell surface extracellular matrix component collagen XVIII . Negative_regulation WNT1 F2R 11433294 832122 Suppressing endogenous function *inhibits* [Wnt] signalling through beta-catenin in mammalian cells , and Xenopus and Drosophila embryos . Negative_regulation WNT1 FOXO1 19737954 2139766 Progesterone induction of DKK1 and *results* in inhibition of [Wnt] signaling in the human endometrium . Negative_regulation WNT1 FOXO1 22550000 2669275 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced dependent *inhibition* of [Wnt/TCF] activity . Negative_regulation WNT1 PCDH19 22193776 2543531 Xenopus paraxial *inhibits* [Wnt/ß-catenin] signalling via casein kinase 2ß . Negative_regulation WNT1 PCDH8 22193776 2543536 Xenopus paraxial *inhibits* [Wnt/ß-catenin] signalling via casein kinase 2ß . Negative_regulation WNT1 WIF1 19174556 2032528 , a [Wnt] pathway *inhibitor* , regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells . Negative_regulation WNT1 WIF1 20573255 2290535 We investigated the effect and underlying mechanism of a naturally occurring [Wnt] *inhibitor* , , on the growth and cellular invasiveness of a bone metastatic PCa cell line , PC3 . Negative_regulation WNT1 WIF1 21652676 2470753 We elected to dysregulate Wnt signaling from the perspective of the stem cell niche by expressing the pan [Wnt] *inhibitor* , , specifically in osteoblasts . Negative_regulation WNT1 WIF1 21928342 2539154 Conversely , CTGF does not interfere with *dependent* inhibition of [Wnt] signalling . Negative_regulation WNT1 WIF1 23784913 2838633 In chondrocytes , TNFa stimulated canonical [Wnt] signaling , which could be *blocked* by , indicating a direct effect of TNFa and WIF-1 on Wnt signaling in this system . Negative_regulation WNT1 WIF1 24362065 2899825 A seven-fold increase in the expression of , an *inhibitor* of [WNT/ß-catenin] signaling , was observed in the Misr2 expressing UGRs . Negative_regulation WNT1 ZIC2 21908606 2496729 Transcription factor *inhibits* [Wnt/ß-catenin] protein signaling . Negative_regulation WNT10B CCND1 18957421 1995063 expression is elevated and [Wnt10b] is *repressed* by cAMP during the first few hours of adipogenesis . Negative_regulation WNT11 ARSA 16282376 1484067 *inhibited* [Wnt] signaling by a dual mechanism : at low concentrations it blocked the formation of beta-catenin/Tcf complexes ( dominant mechanism ) , and at higher concentrations it also cleaved beta-catenin . Negative_regulation WNT11 AXIN2 15572025 1355625 Further , we show that can *repress* [Wnt] signalling leading to reduced cell growth and increased cell death . Negative_regulation WNT11 AXIN2 16881048 1625562 While Notch can regulate ectopic Wingless signalling caused by loss of function of Shaggy , it can only partially regulate the ectopic [Wnt] signalling *induced* by the loss of function . Negative_regulation WNT11 AXIN2 17373666 1741400 In this assay , *inhibited* [Wnt] signaling demonstrated in luciferase reporter assays . Negative_regulation WNT11 AXIN2 18632632 1937074 Transfection of C4-2B cells with , an *inhibitor* of canonical [Wnt] signaling , blocked Wnt3a but not Wnt5a induction of the BMP promoters . Negative_regulation WNT11 AXIN2 18951693 2014574 [Wnt] pathway *inhibitors* , ( intracellular ) or Dickkopf-1 ( extracellular ) blocked the regulation of VCAM-1 by diffusible Wnt3a . Negative_regulation WNT11 AXIN2 19581931 2122493 Both PP1 and bind to the N-terminus of Dab2 and a Dab2 truncation mutant consisting of the N-terminal phosphotyrosine binding domain blocks PP1-Axin interactions and *inhibits* [Wnt] signaling . Negative_regulation WNT11 AXIN2 19888210 2161325 We show that Ube2m interacts with and modulates beta-catenin stability , and that the antagonistic effect of Nkd1 on [Wnt] signaling *requires* interaction with , itself a negative pathway regulator . Negative_regulation WNT11 AXIN2 21555575 2435399 Tissue-specific *roles* of in the inhibition and activation of [Wnt] signaling in the mouse embryo . Negative_regulation WNT11 AXIN2 21555575 2435420 The results indicate that although increased stability of *leads* to a loss of canonical [Wnt] signaling in most tissues , stabilized Axin2 enhances Wnt pathway activity in a specific progenitor population in the late primitive streak . Negative_regulation WNT11 AXIN2 22322943 2592190 CDC20-resistant *inhibits* [Wnt] signalling and attenuates colony formation of colorectal cancer cells . Negative_regulation WNT11 AXIN2 22957046 2667733 Differential *role* of RGS domain function in [Wnt] signaling during anteroposterior patterning and maternal axis formation . Negative_regulation WNT11 AXIN2 22957046 2667833 This study was performed to test the hypothesis that RGS-Gna interactions would be *required* to attenuate [Wnt] signaling . Negative_regulation WNT11 CCND1 20856206 2381653 One of such molecules is V3Nter , a soluble SFRP-like frizzled polypeptide that binds to Wnt3a and *inhibits* [Wnt] signaling and expression of the ß-catenin target genes and c-myc. V3Nter is derived from the cell surface extracellular matrix component collagen XVIII . Negative_regulation WNT11 F2R 11433294 832123 Suppressing endogenous function *inhibits* [Wnt] signalling through beta-catenin in mammalian cells , and Xenopus and Drosophila embryos . Negative_regulation WNT11 FOXO1 19737954 2139768 Progesterone induction of DKK1 and *results* in inhibition of [Wnt] signaling in the human endometrium . Negative_regulation WNT11 FOXO1 22550000 2669279 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced dependent *inhibition* of [Wnt/TCF] activity . Negative_regulation WNT11 PCDH19 22193776 2543542 Xenopus paraxial *inhibits* [Wnt/ß-catenin] signalling via casein kinase 2ß . Negative_regulation WNT11 PCDH8 22193776 2543547 Xenopus paraxial *inhibits* [Wnt/ß-catenin] signalling via casein kinase 2ß . Negative_regulation WNT11 WIF1 19174556 2032529 , a [Wnt] pathway *inhibitor* , regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells . Negative_regulation WNT11 WIF1 20573255 2290536 We investigated the effect and underlying mechanism of a naturally occurring [Wnt] *inhibitor* , , on the growth and cellular invasiveness of a bone metastatic PCa cell line , PC3 . Negative_regulation WNT11 WIF1 21652676 2470754 We elected to dysregulate Wnt signaling from the perspective of the stem cell niche by expressing the pan [Wnt] *inhibitor* , , specifically in osteoblasts . Negative_regulation WNT11 WIF1 21928342 2539155 Conversely , CTGF does not interfere with dependent *inhibition* of [Wnt] signalling . Negative_regulation WNT11 WIF1 23784913 2838634 In chondrocytes , TNFa stimulated canonical [Wnt] signaling , which could be *blocked* by , indicating a direct effect of TNFa and WIF-1 on Wnt signaling in this system . Negative_regulation WNT11 WIF1 24362065 2899826 A seven-fold increase in the expression of , an *inhibitor* of [WNT/ß-catenin] signaling , was observed in the Misr2 expressing UGRs . Negative_regulation WNT11 ZIC2 21908606 2496730 Transcription factor *inhibits* [Wnt/ß-catenin] protein signaling . Negative_regulation WNT16 ARSA 16282376 1484072 *inhibited* [Wnt] signaling by a dual mechanism : at low concentrations it blocked the formation of beta-catenin/Tcf complexes ( dominant mechanism ) , and at higher concentrations it also cleaved beta-catenin . Negative_regulation WNT16 AXIN2 15572025 1355630 Further , we show that can *repress* [Wnt] signalling leading to reduced cell growth and increased cell death . Negative_regulation WNT16 AXIN2 16881048 1625572 While Notch can regulate ectopic Wingless signalling caused by loss of function of Shaggy , it can only partially regulate the ectopic [Wnt] signalling *induced* by the loss of function . Negative_regulation WNT16 AXIN2 17373666 1741405 In this assay , *inhibited* [Wnt] signaling demonstrated in luciferase reporter assays . Negative_regulation WNT16 AXIN2 18632632 1937084 Transfection of C4-2B cells with , an *inhibitor* of canonical [Wnt] signaling , blocked Wnt3a but not Wnt5a induction of the BMP promoters . Negative_regulation WNT16 AXIN2 18951693 2014589 [Wnt] pathway *inhibitors* , ( intracellular ) or Dickkopf-1 ( extracellular ) blocked the regulation of VCAM-1 by diffusible Wnt3a . Negative_regulation WNT16 AXIN2 19581931 2122508 Both PP1 and bind to the N-terminus of Dab2 and a Dab2 truncation mutant consisting of the N-terminal phosphotyrosine binding domain blocks PP1-Axin interactions and *inhibits* [Wnt] signaling . Negative_regulation WNT16 AXIN2 19888210 2161340 We show that Ube2m interacts with and modulates beta-catenin stability , and that the antagonistic effect of Nkd1 on [Wnt] signaling *requires* interaction with , itself a negative pathway regulator . Negative_regulation WNT16 AXIN2 21555575 2435404 Tissue-specific *roles* of in the inhibition and activation of [Wnt] signaling in the mouse embryo . Negative_regulation WNT16 AXIN2 21555575 2435425 The results indicate that although increased stability of *leads* to a loss of canonical [Wnt] signaling in most tissues , stabilized Axin2 enhances Wnt pathway activity in a specific progenitor population in the late primitive streak . Negative_regulation WNT16 AXIN2 22322943 2592195 CDC20-resistant *inhibits* [Wnt] signalling and attenuates colony formation of colorectal cancer cells . Negative_regulation WNT16 AXIN2 22957046 2667748 Differential *role* of RGS domain function in [Wnt] signaling during anteroposterior patterning and maternal axis formation . Negative_regulation WNT16 AXIN2 22957046 2667873 This study was performed to test the hypothesis that RGS-Gna interactions would be *required* to attenuate [Wnt] signaling . Negative_regulation WNT16 CCND1 20856206 2381665 One of such molecules is V3Nter , a soluble SFRP-like frizzled polypeptide that binds to Wnt3a and *inhibits* [Wnt] signaling and expression of the ß-catenin target genes and c-myc. V3Nter is derived from the cell surface extracellular matrix component collagen XVIII . Negative_regulation WNT16 F2R 11433294 832128 Suppressing endogenous function *inhibits* [Wnt] signalling through beta-catenin in mammalian cells , and Xenopus and Drosophila embryos . Negative_regulation WNT16 FOXO1 19737954 2139778 Progesterone induction of DKK1 and *results* in inhibition of [Wnt] signaling in the human endometrium . Negative_regulation WNT16 FOXO1 22550000 2669299 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced dependent *inhibition* of [Wnt/TCF] activity . Negative_regulation WNT16 PCDH19 22193776 2543597 Xenopus paraxial *inhibits* [Wnt/ß-catenin] signalling via casein kinase 2ß . Negative_regulation WNT16 PCDH8 22193776 2543602 Xenopus paraxial *inhibits* [Wnt/ß-catenin] signalling via casein kinase 2ß . Negative_regulation WNT16 WIF1 19174556 2032534 , a [Wnt] pathway *inhibitor* , regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells . Negative_regulation WNT16 WIF1 20573255 2290541 We investigated the effect and underlying mechanism of a naturally occurring [Wnt] *inhibitor* , , on the growth and cellular invasiveness of a bone metastatic PCa cell line , PC3 . Negative_regulation WNT16 WIF1 21652676 2470759 We elected to dysregulate Wnt signaling from the perspective of the stem cell niche by expressing the pan [Wnt] *inhibitor* , , specifically in osteoblasts . Negative_regulation WNT16 WIF1 21928342 2539160 Conversely , CTGF does not interfere with *dependent* inhibition of [Wnt] signalling . Negative_regulation WNT16 WIF1 23784913 2838639 In chondrocytes , TNFa stimulated canonical [Wnt] signaling , which could be *blocked* by , indicating a direct effect of TNFa and WIF-1 on Wnt signaling in this system . Negative_regulation WNT16 WIF1 24362065 2899831 A seven-fold increase in the expression of , an *inhibitor* of [WNT/ß-catenin] signaling , was observed in the Misr2 expressing UGRs . Negative_regulation WNT16 ZIC2 21908606 2496735 Transcription factor *inhibits* [Wnt/ß-catenin] protein signaling . Negative_regulation WNT2 ARSA 16282376 1484068 *inhibited* [Wnt] signaling by a dual mechanism : at low concentrations it blocked the formation of beta-catenin/Tcf complexes ( dominant mechanism ) , and at higher concentrations it also cleaved beta-catenin . Negative_regulation WNT2 AXIN2 15572025 1355626 Further , we show that can *repress* [Wnt] signalling leading to reduced cell growth and increased cell death . Negative_regulation WNT2 AXIN2 16881048 1625564 While Notch can regulate ectopic Wingless signalling caused by loss of function of Shaggy , it can only partially regulate the ectopic [Wnt] signalling *induced* by the loss of function . Negative_regulation WNT2 AXIN2 17373666 1741401 In this assay , *inhibited* [Wnt] signaling demonstrated in luciferase reporter assays . Negative_regulation WNT2 AXIN2 18632632 1937076 Transfection of C4-2B cells with , an *inhibitor* of canonical [Wnt] signaling , blocked Wnt3a but not Wnt5a induction of the BMP promoters . Negative_regulation WNT2 AXIN2 18951693 2014577 [Wnt] pathway *inhibitors* , ( intracellular ) or Dickkopf-1 ( extracellular ) blocked the regulation of VCAM-1 by diffusible Wnt3a . Negative_regulation WNT2 AXIN2 19581931 2122496 Both PP1 and bind to the N-terminus of Dab2 and a Dab2 truncation mutant consisting of the N-terminal phosphotyrosine binding domain blocks PP1-Axin interactions and *inhibits* [Wnt] signaling . Negative_regulation WNT2 AXIN2 19888210 2161328 We show that Ube2m interacts with and modulates beta-catenin stability , and that the antagonistic effect of Nkd1 on [Wnt] signaling *requires* interaction with , itself a negative pathway regulator . Negative_regulation WNT2 AXIN2 21555575 2435400 Tissue-specific *roles* of in the inhibition and activation of [Wnt] signaling in the mouse embryo . Negative_regulation WNT2 AXIN2 21555575 2435421 The results indicate that although increased stability of *leads* to a loss of canonical [Wnt] signaling in most tissues , stabilized Axin2 enhances Wnt pathway activity in a specific progenitor population in the late primitive streak . Negative_regulation WNT2 AXIN2 22322943 2592191 CDC20-resistant *inhibits* [Wnt] signalling and attenuates colony formation of colorectal cancer cells . Negative_regulation WNT2 AXIN2 22957046 2667736 Differential *role* of RGS domain function in [Wnt] signaling during anteroposterior patterning and maternal axis formation . Negative_regulation WNT2 AXIN2 22957046 2667841 This study was performed to test the hypothesis that RGS-Gna interactions would be *required* to attenuate [Wnt] signaling . Negative_regulation WNT2 CCND1 20856206 2381654 One of such molecules is V3Nter , a soluble SFRP-like frizzled polypeptide that binds to Wnt3a and *inhibits* [Wnt] signaling and expression of the ß-catenin target genes and c-myc. V3Nter is derived from the cell surface extracellular matrix component collagen XVIII . Negative_regulation WNT2 F2R 11433294 832124 Suppressing endogenous function *inhibits* [Wnt] signalling through beta-catenin in mammalian cells , and Xenopus and Drosophila embryos . Negative_regulation WNT2 FOXO1 19737954 2139770 Progesterone induction of DKK1 and *results* in inhibition of [Wnt] signaling in the human endometrium . Negative_regulation WNT2 FOXO1 22550000 2669283 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced dependent *inhibition* of [Wnt/TCF] activity . Negative_regulation WNT2 PCDH19 22193776 2543553 Xenopus paraxial *inhibits* [Wnt/ß-catenin] signalling via casein kinase 2ß . Negative_regulation WNT2 PCDH8 22193776 2543558 Xenopus paraxial *inhibits* [Wnt/ß-catenin] signalling via casein kinase 2ß . Negative_regulation WNT2 WIF1 19174556 2032530 , a [Wnt] pathway *inhibitor* , regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells . Negative_regulation WNT2 WIF1 20573255 2290537 We investigated the effect and underlying mechanism of a naturally occurring [Wnt] *inhibitor* , , on the growth and cellular invasiveness of a bone metastatic PCa cell line , PC3 . Negative_regulation WNT2 WIF1 21652676 2470755 We elected to dysregulate Wnt signaling from the perspective of the stem cell niche by expressing the pan [Wnt] *inhibitor* , , specifically in osteoblasts . Negative_regulation WNT2 WIF1 21928342 2539156 Conversely , CTGF does not interfere with *dependent* inhibition of [Wnt] signalling . Negative_regulation WNT2 WIF1 23784913 2838635 In chondrocytes , TNFa stimulated canonical [Wnt] signaling , which could be *blocked* by , indicating a direct effect of TNFa and WIF-1 on Wnt signaling in this system . Negative_regulation WNT2 WIF1 24362065 2899827 A seven-fold increase in the expression of , an *inhibitor* of [WNT/ß-catenin] signaling , was observed in the Misr2 expressing UGRs . Negative_regulation WNT2 ZIC2 21908606 2496731 Transcription factor *inhibits* [Wnt/ß-catenin] protein signaling . Negative_regulation WNT3 ARSA 16282376 1484069 *inhibited* [Wnt] signaling by a dual mechanism : at low concentrations it blocked the formation of beta-catenin/Tcf complexes ( dominant mechanism ) , and at higher concentrations it also cleaved beta-catenin . Negative_regulation WNT3 AXIN2 15572025 1355627 Further , we show that can *repress* [Wnt] signalling leading to reduced cell growth and increased cell death . Negative_regulation WNT3 AXIN2 16881048 1625566 While Notch can regulate ectopic Wingless signalling caused by loss of function of Shaggy , it can only partially regulate the ectopic [Wnt] signalling *induced* by the loss of function . Negative_regulation WNT3 AXIN2 17373666 1741402 In this assay , *inhibited* [Wnt] signaling demonstrated in luciferase reporter assays . Negative_regulation WNT3 AXIN2 18632632 1937078 Transfection of C4-2B cells with , an *inhibitor* of canonical [Wnt] signaling , blocked Wnt3a but not Wnt5a induction of the BMP promoters . Negative_regulation WNT3 AXIN2 18951693 2014580 [Wnt] pathway *inhibitors* , ( intracellular ) or Dickkopf-1 ( extracellular ) blocked the regulation of VCAM-1 by diffusible Wnt3a . Negative_regulation WNT3 AXIN2 19581931 2122499 Both PP1 and bind to the N-terminus of Dab2 and a Dab2 truncation mutant consisting of the N-terminal phosphotyrosine binding domain blocks PP1-Axin interactions and *inhibits* [Wnt] signaling . Negative_regulation WNT3 AXIN2 19888210 2161331 We show that Ube2m interacts with and modulates beta-catenin stability , and that the antagonistic effect of Nkd1 on [Wnt] signaling *requires* interaction with , itself a negative pathway regulator . Negative_regulation WNT3 AXIN2 21555575 2435401 Tissue-specific *roles* of in the inhibition and activation of [Wnt] signaling in the mouse embryo . Negative_regulation WNT3 AXIN2 21555575 2435422 The results indicate that although increased stability of *leads* to a loss of canonical [Wnt] signaling in most tissues , stabilized Axin2 enhances Wnt pathway activity in a specific progenitor population in the late primitive streak . Negative_regulation WNT3 AXIN2 22322943 2592192 CDC20-resistant *inhibits* [Wnt] signalling and attenuates colony formation of colorectal cancer cells . Negative_regulation WNT3 AXIN2 22957046 2667739 Differential *role* of RGS domain function in [Wnt] signaling during anteroposterior patterning and maternal axis formation . Negative_regulation WNT3 AXIN2 22957046 2667849 This study was performed to test the hypothesis that RGS-Gna interactions would be *required* to attenuate [Wnt] signaling . Negative_regulation WNT3 CCND1 20856206 2381655 One of such molecules is V3Nter , a soluble SFRP-like frizzled polypeptide that binds to Wnt3a and *inhibits* [Wnt] signaling and expression of the ß-catenin target genes and c-myc. V3Nter is derived from the cell surface extracellular matrix component collagen XVIII . Negative_regulation WNT3 F2R 11433294 832125 Suppressing endogenous function *inhibits* [Wnt] signalling through beta-catenin in mammalian cells , and Xenopus and Drosophila embryos . Negative_regulation WNT3 FOXO1 19737954 2139772 Progesterone induction of DKK1 and *results* in inhibition of [Wnt] signaling in the human endometrium . Negative_regulation WNT3 FOXO1 22550000 2669287 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced dependent *inhibition* of [Wnt/TCF] activity . Negative_regulation WNT3 MSX1 19815336 2209316 induces the Wnt pathway antagonist genes DKK1 , DKK2 , DKK3 , and SFRP1 in neuroblastoma cells , but does not *block* [Wnt3] and Wnt5A signalling to DVL3 . Negative_regulation WNT3 PCDH19 22193776 2543564 Xenopus paraxial *inhibits* [Wnt/ß-catenin] signalling via casein kinase 2ß . Negative_regulation WNT3 PCDH8 22193776 2543569 Xenopus paraxial *inhibits* [Wnt/ß-catenin] signalling via casein kinase 2ß . Negative_regulation WNT3 WIF1 19174556 2032531 , a [Wnt] pathway *inhibitor* , regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells . Negative_regulation WNT3 WIF1 20573255 2290538 We investigated the effect and underlying mechanism of a naturally occurring [Wnt] *inhibitor* , , on the growth and cellular invasiveness of a bone metastatic PCa cell line , PC3 . Negative_regulation WNT3 WIF1 21652676 2470756 We elected to dysregulate Wnt signaling from the perspective of the stem cell niche by expressing the pan [Wnt] *inhibitor* , , specifically in osteoblasts . Negative_regulation WNT3 WIF1 21928342 2539157 Conversely , CTGF does not interfere with dependent *inhibition* of [Wnt] signalling . Negative_regulation WNT3 WIF1 23784913 2838636 In chondrocytes , TNFa stimulated canonical [Wnt] signaling , which could be *blocked* by , indicating a direct effect of TNFa and WIF-1 on Wnt signaling in this system . Negative_regulation WNT3 WIF1 24362065 2899828 A seven-fold increase in the expression of , an *inhibitor* of [WNT/ß-catenin] signaling , was observed in the Misr2 expressing UGRs . Negative_regulation WNT3 ZIC2 21908606 2496732 Transcription factor *inhibits* [Wnt/ß-catenin] protein signaling . Negative_regulation WNT4 ARSA 16282376 1484070 *inhibited* [Wnt] signaling by a dual mechanism : at low concentrations it blocked the formation of beta-catenin/Tcf complexes ( dominant mechanism ) , and at higher concentrations it also cleaved beta-catenin . Negative_regulation WNT4 AXIN2 15572025 1355628 Further , we show that can *repress* [Wnt] signalling leading to reduced cell growth and increased cell death . Negative_regulation WNT4 AXIN2 16881048 1625568 While Notch can regulate ectopic Wingless signalling caused by loss of function of Shaggy , it can only partially regulate the ectopic [Wnt] signalling *induced* by the loss of function . Negative_regulation WNT4 AXIN2 17373666 1741403 In this assay , *inhibited* [Wnt] signaling demonstrated in luciferase reporter assays . Negative_regulation WNT4 AXIN2 18632632 1937080 Transfection of C4-2B cells with , an *inhibitor* of canonical [Wnt] signaling , blocked Wnt3a but not Wnt5a induction of the BMP promoters . Negative_regulation WNT4 AXIN2 18951693 2014583 [Wnt] pathway *inhibitors* , ( intracellular ) or Dickkopf-1 ( extracellular ) blocked the regulation of VCAM-1 by diffusible Wnt3a . Negative_regulation WNT4 AXIN2 19581931 2122502 Both PP1 and bind to the N-terminus of Dab2 and a Dab2 truncation mutant consisting of the N-terminal phosphotyrosine binding domain blocks PP1-Axin interactions and *inhibits* [Wnt] signaling . Negative_regulation WNT4 AXIN2 19888210 2161334 We show that Ube2m interacts with and modulates beta-catenin stability , and that the antagonistic effect of Nkd1 on [Wnt] signaling *requires* interaction with , itself a negative pathway regulator . Negative_regulation WNT4 AXIN2 21555575 2435402 Tissue-specific *roles* of in the inhibition and activation of [Wnt] signaling in the mouse embryo . Negative_regulation WNT4 AXIN2 21555575 2435423 The results indicate that although increased stability of *leads* to a loss of canonical [Wnt] signaling in most tissues , stabilized Axin2 enhances Wnt pathway activity in a specific progenitor population in the late primitive streak . Negative_regulation WNT4 AXIN2 22322943 2592193 CDC20-resistant *inhibits* [Wnt] signalling and attenuates colony formation of colorectal cancer cells . Negative_regulation WNT4 AXIN2 22957046 2667742 Differential *role* of RGS domain function in [Wnt] signaling during anteroposterior patterning and maternal axis formation . Negative_regulation WNT4 AXIN2 22957046 2667857 This study was performed to test the hypothesis that RGS-Gna interactions would be *required* to attenuate [Wnt] signaling . Negative_regulation WNT4 CCND1 20856206 2381656 One of such molecules is V3Nter , a soluble SFRP-like frizzled polypeptide that binds to Wnt3a and *inhibits* [Wnt] signaling and expression of the ß-catenin target genes and c-myc. V3Nter is derived from the cell surface extracellular matrix component collagen XVIII . Negative_regulation WNT4 F2R 11433294 832126 Suppressing endogenous function *inhibits* [Wnt] signalling through beta-catenin in mammalian cells , and Xenopus and Drosophila embryos . Negative_regulation WNT4 FOXO1 19737954 2139774 Progesterone induction of DKK1 and *results* in inhibition of [Wnt] signaling in the human endometrium . Negative_regulation WNT4 FOXO1 22550000 2669291 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced dependent *inhibition* of [Wnt/TCF] activity . Negative_regulation WNT4 PCDH19 22193776 2543575 Xenopus paraxial *inhibits* [Wnt/ß-catenin] signalling via casein kinase 2ß . Negative_regulation WNT4 PCDH8 22193776 2543580 Xenopus paraxial *inhibits* [Wnt/ß-catenin] signalling via casein kinase 2ß . Negative_regulation WNT4 WIF1 19174556 2032532 , a [Wnt] pathway *inhibitor* , regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells . Negative_regulation WNT4 WIF1 20573255 2290539 We investigated the effect and underlying mechanism of a naturally occurring [Wnt] *inhibitor* , , on the growth and cellular invasiveness of a bone metastatic PCa cell line , PC3 . Negative_regulation WNT4 WIF1 21652676 2470757 We elected to dysregulate Wnt signaling from the perspective of the stem cell niche by expressing the pan [Wnt] *inhibitor* , , specifically in osteoblasts . Negative_regulation WNT4 WIF1 21928342 2539158 Conversely , CTGF does not interfere with *dependent* inhibition of [Wnt] signalling . Negative_regulation WNT4 WIF1 23784913 2838637 In chondrocytes , TNFa stimulated canonical [Wnt] signaling , which could be *blocked* by , indicating a direct effect of TNFa and WIF-1 on Wnt signaling in this system . Negative_regulation WNT4 WIF1 24362065 2899829 A seven-fold increase in the expression of , an *inhibitor* of [WNT/ß-catenin] signaling , was observed in the Misr2 expressing UGRs . Negative_regulation WNT4 ZIC2 21908606 2496733 Transcription factor *inhibits* [Wnt/ß-catenin] protein signaling . Negative_regulation WNT5A MSX1 19815336 2209317 induces the Wnt pathway antagonist genes DKK1 , DKK2 , DKK3 , and SFRP1 in neuroblastoma cells , but does not *block* Wnt3 and [Wnt5A] signalling to DVL3 . Negative_regulation WNT6 ARSA 16282376 1484071 *inhibited* [Wnt] signaling by a dual mechanism : at low concentrations it blocked the formation of beta-catenin/Tcf complexes ( dominant mechanism ) , and at higher concentrations it also cleaved beta-catenin . Negative_regulation WNT6 AXIN2 15572025 1355629 Further , we show that can *repress* [Wnt] signalling leading to reduced cell growth and increased cell death . Negative_regulation WNT6 AXIN2 16881048 1625570 While Notch can regulate ectopic Wingless signalling caused by loss of function of Shaggy , it can only partially regulate the ectopic [Wnt] signalling *induced* by the loss of function . Negative_regulation WNT6 AXIN2 17373666 1741404 In this assay , *inhibited* [Wnt] signaling demonstrated in luciferase reporter assays . Negative_regulation WNT6 AXIN2 18632632 1937082 Transfection of C4-2B cells with , an *inhibitor* of canonical [Wnt] signaling , blocked Wnt3a but not Wnt5a induction of the BMP promoters . Negative_regulation WNT6 AXIN2 18951693 2014586 [Wnt] pathway *inhibitors* , ( intracellular ) or Dickkopf-1 ( extracellular ) blocked the regulation of VCAM-1 by diffusible Wnt3a . Negative_regulation WNT6 AXIN2 19581931 2122505 Both PP1 and bind to the N-terminus of Dab2 and a Dab2 truncation mutant consisting of the N-terminal phosphotyrosine binding domain blocks PP1-Axin interactions and *inhibits* [Wnt] signaling . Negative_regulation WNT6 AXIN2 19888210 2161337 We show that Ube2m interacts with and modulates beta-catenin stability , and that the antagonistic effect of Nkd1 on [Wnt] signaling *requires* interaction with , itself a negative pathway regulator . Negative_regulation WNT6 AXIN2 21555575 2435403 Tissue-specific *roles* of in the inhibition and activation of [Wnt] signaling in the mouse embryo . Negative_regulation WNT6 AXIN2 21555575 2435424 The results indicate that although increased stability of *leads* to a loss of canonical [Wnt] signaling in most tissues , stabilized Axin2 enhances Wnt pathway activity in a specific progenitor population in the late primitive streak . Negative_regulation WNT6 AXIN2 22322943 2592194 CDC20-resistant *inhibits* [Wnt] signalling and attenuates colony formation of colorectal cancer cells . Negative_regulation WNT6 AXIN2 22957046 2667745 Differential *role* of RGS domain function in [Wnt] signaling during anteroposterior patterning and maternal axis formation . Negative_regulation WNT6 AXIN2 22957046 2667865 This study was performed to test the hypothesis that RGS-Gna interactions would be *required* to attenuate [Wnt] signaling . Negative_regulation WNT6 CCND1 20856206 2381657 One of such molecules is V3Nter , a soluble SFRP-like frizzled polypeptide that binds to Wnt3a and *inhibits* [Wnt] signaling and expression of the ß-catenin target genes and c-myc. V3Nter is derived from the cell surface extracellular matrix component collagen XVIII . Negative_regulation WNT6 F2R 11433294 832127 Suppressing endogenous function *inhibits* [Wnt] signalling through beta-catenin in mammalian cells , and Xenopus and Drosophila embryos . Negative_regulation WNT6 FOXO1 19737954 2139776 Progesterone induction of DKK1 and *results* in inhibition of [Wnt] signaling in the human endometrium . Negative_regulation WNT6 FOXO1 22550000 2669295 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced dependent *inhibition* of [Wnt/TCF] activity . Negative_regulation WNT6 PCDH19 22193776 2543586 Xenopus paraxial *inhibits* [Wnt/ß-catenin] signalling via casein kinase 2ß . Negative_regulation WNT6 PCDH8 22193776 2543591 Xenopus paraxial *inhibits* [Wnt/ß-catenin] signalling via casein kinase 2ß . Negative_regulation WNT6 WIF1 19174556 2032533 , a [Wnt] pathway *inhibitor* , regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells . Negative_regulation WNT6 WIF1 20573255 2290540 We investigated the effect and underlying mechanism of a naturally occurring [Wnt] *inhibitor* , , on the growth and cellular invasiveness of a bone metastatic PCa cell line , PC3 . Negative_regulation WNT6 WIF1 21652676 2470758 We elected to dysregulate Wnt signaling from the perspective of the stem cell niche by expressing the pan [Wnt] *inhibitor* , , specifically in osteoblasts . Negative_regulation WNT6 WIF1 21928342 2539159 Conversely , CTGF does not interfere with dependent *inhibition* of [Wnt] signalling . Negative_regulation WNT6 WIF1 23784913 2838638 In chondrocytes , TNFa stimulated canonical [Wnt] signaling , which could be *blocked* by , indicating a direct effect of TNFa and WIF-1 on Wnt signaling in this system . Negative_regulation WNT6 WIF1 24362065 2899830 A seven-fold increase in the expression of , an *inhibitor* of [WNT/ß-catenin] signaling , was observed in the Misr2 expressing UGRs . Negative_regulation WNT6 ZIC2 21908606 2496734 Transcription factor *inhibits* [Wnt/ß-catenin] protein signaling . Negative_regulation WNT7A DES 15458790 1301571 *mediated* reduction in uterine Hoxa10 , Hoxa11 and [Wnt7a] expression that occurs wild-type females during the time of exposure was also absent in alphaERKO females . Negative_regulation WNT7A EN1 9199358 438930 We show that ectopic expression in dorsal ectoderm is *sufficient* to repress the endogenous expression of the dorsal ectodermal marker [Wnt7a] , with a resultant decrease in Lmx1 expression in underlying dorsal mesenchyme . Negative_regulation WNT7A FGF2 15142975 1252165 Overexpression of [Wnt7a] or of a stabilized form of beta-catenin in mouse cortical NPC cultures induced neuronal differentiation even in the *presence* of , a self-renewal promoting factor in this system . Negative_regulation WNT7A MAPK10 21941371 2562384 Palmitoylation-deficient JNK3 mimics the effect of Wnt7a application on axonal branching , whereas constitutively palmitoylated results in reduced axonal branches and *blocked* [Wnt7a] induction . Negative_regulation WNT7A NEUROD1 15142975 1252166 Overexpression of [Wnt7a] or of a stabilized form of beta-catenin in mouse cortical NPC cultures *induced* even in the presence of Fgf2 , a self-renewal promoting factor in this system . Negative_regulation WNT7A NEUROD2 15142975 1252167 Overexpression of [Wnt7a] or of a stabilized form of beta-catenin in mouse cortical NPC cultures *induced* even in the presence of Fgf2 , a self-renewal promoting factor in this system . Negative_regulation WNT7A NEUROD4 15142975 1252163 Overexpression of [Wnt7a] or of a stabilized form of beta-catenin in mouse cortical NPC cultures *induced* even in the presence of Fgf2 , a self-renewal promoting factor in this system . Negative_regulation WNT7A NEUROD6 15142975 1252164 Overexpression of [Wnt7a] or of a stabilized form of beta-catenin in mouse cortical NPC cultures *induced* even in the presence of Fgf2 , a self-renewal promoting factor in this system . Negative_regulation WNT7A POLDIP2 11822875 909128 The combination of Wnt-7a misexpression and Erk inhibition partially recovers Wnt-7a inhibition of chondrogenic differentiation , whereas the combination of [Wnt-7a] misexpression and *inhibition* acts in a synergistic chondro-inhibitory fashion . Negative_regulation WWOX TNF 11058590 809693 Induction of mitochondrial permeability transition by , staurosporine , and atractyloside *resulted* in [WOX1] release from mitochondria and subsequent nuclear translocation . Negative_regulation XAF1 EPHB2 23323858 2753002 We found that activation of *resulted* in a decrease in [XAF1] [ XIAP ( X-linked inhibitor of apoptosis ) -associated factor 1 ] which reduced the formation of the XIAP-XAF1 E3 ligase complex to ubiquitinate survivin . Negative_regulation XCR1 LRRC31 24594994 2929718 [G-protein coupled receptor 5] *inhibition* could serve as a novel therapeutic approach . Negative_regulation XCR1 LRRC55 24594994 2929737 [G-protein coupled receptor 5] *inhibition* could serve as a novel therapeutic approach . Negative_regulation XDH TNF 16385082 1520074 Activation of [xanthine oxidase] with I/R was *prevented* by allopurinol or . Negative_regulation XIAP CAPN8 12469198 1032285 Taken together , the apoptotic effects of NPPA may be related , in part to the caspase-3 activation , the down-regulation of [XIAP] , and Bax cleavage *mediated* by caspase dependent activation . Negative_regulation XIAP DAPK1 22465880 2588974 In addition , over-expression of from either TNF-a or INF-?-treatment cells *suppressed* the anti-apoptosis protein [XIAP] as well as COX-2 and ICAM-1 , more than control . Negative_regulation XIAP TNF 11005210 735061 However , [XIAP] expression was *down-regulated* by , which induced apoptotic cell death of HSG cells with an increase in caspase-3 activity . Negative_regulation XIAP TNF 15122760 1242263 CPT treatment completely abrogated the induced NF-kappa B activation , and mRNA expression of the antiapoptotic factors TNF-receptor associated factor 2 , FLICE-inhibitory protein , and [X-linked inhibitor of apoptosis protein] was also *inhibited* by CPT. The caspase inhibitors benzyloxycarbonyl-Val-Ala-Asp- ( OMe ) -fluoromethylketone ( zVAD-fmk ) and benzyloxycarbonyl-Asp ( OMe ) -Glu ( OMe ) -Val-Asp ( OMe ) -chloromethylketone ( zDEVD-fmk ) , as well as depletion of intracellular ATP by fructose prevented CPT/TNF induced apoptosis . Negative_regulation XIAP TNF 18467439 1938887 In addition , inhibition of protein kinase C activity enhanced *induced* down-regulation of [XIAP] and potentiated apoptosis induction , in both Ishikawa and Hec-1A cells . Negative_regulation XIAP TNF 21296074 2398396 These results correlate with downregulation of *induced* expression of protective NF-?B target genes like MnSOD , [XIAP] or A20 . Negative_regulation XIAP TNFSF10 15385934 1324178 induced no discernible changes in FLIP , DR4 , DR5 , Mcl-1 , or survivin expression , modest declines in levels of DcR2 and c-IAP , but *resulted* in the marked transcriptional downregulation of [XIAP] . Negative_regulation XIAP TNFSF10 20127709 2226877 *induced* reduction of [XIAP] and c-FLIP protein levels in Par-4 overexpressing cells was prevented by z-VAD pretreatment . Negative_regulation XIAP TNFSF10 20951133 2365034 *induced* loss of cIAP-1 and [XIAP] requires caspase activity . Negative_regulation XPO1 TNF 22025632 2508060 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Negative_regulation XRCC1 EGLN3 24477694 2913238 We previously found that hypoxia-inducible factor ( HIF) prolyl hydroxylase-3 (PHD3 ) was frequently overexpressed in renal cell carcinomas ( RCCs ) , unlike in normal tissues , and therefore , we studied the mechanism and *role* of expression in [RCC] . Negative_regulation XRCC1 TGM2 23704086 2833891 However , the key *role* of in [RCC] was not clear . Negative_regulation XRCC5 DGKI 15894621 1411621 regulates Ras guanyl releasing protein 3 and *inhibits* [Rap1] signaling . Negative_regulation XRCC5 DGKI 15894621 1411651 We demonstrate that bound to RasGRP3 and *inhibited* its activation of [Rap1] by metabolizing DAG . Negative_regulation XRCC5 MAP2K6 17646383 1793319 The downregulation of [Rap1GAP] by Ras *required* the activation of the signal regulated kinase cascade and was correlated with the induction of mesenchymal morphology and migratory behavior . Negative_regulation XRCC6 DGKI 15894621 1411627 regulates Ras guanyl releasing protein 3 and *inhibits* [Rap1] signaling . Negative_regulation XRCC6 DGKI 15894621 1411654 We demonstrate that bound to RasGRP3 and *inhibited* its activation of [Rap1] by metabolizing DAG . Negative_regulation XRCC6 MAP2K6 17646383 1793340 The downregulation of [Rap1GAP] by Ras *required* the activation of the signal regulated kinase cascade and was correlated with the induction of mesenchymal morphology and migratory behavior . Negative_regulation XRN1 TNF 2226778 144484 Stability studies of IL-6 transcripts in fibroblasts showed that *delayed* IL-6 [mRNA decay] but not LT . Negative_regulation XRN2 TNF 2226778 144478 Stability studies of IL-6 transcripts in fibroblasts showed that *delayed* IL-6 [mRNA decay] but not LT . Negative_regulation XYLT1 IL1B 19001053 2034976 Interestingly , , the main proinflammatory cytokine incriminated in joint diseases , *down-regulated* the [XT-I] gene expression with a concomitant decrease in PG synthesis in rat cartilage explants ex vivo . Negative_regulation YBX1 TNF 12946103 1136783 In summary , blocks expression of osteoblast differentiation markers and *inhibits* beta-glycerophosphate induced activation of the osteoblast differentiation factor [cbfa1] . Negative_regulation YBX1 TNF 16813528 1580728 *inhibits* expression of osteoblast differentiation factor [cbfa1] and osteoblast differentiation in vitro and yet TNF-alpha signaling is essential for bone fracture healing . Negative_regulation YBX1 TNF 16813528 1580733 At the injured growth plate on day 8 , inhibition *increased* expression of [cbfa1] and osteocalcin and increased trabecular bone formation at the injury site . Negative_regulation YWHAB EPHB2 20810616 2341715 We found that nanomolar concentrations of Sorafenib reduced the basal activity of , *inhibited* cAMP dependent activation of [B-Raf] and MEK/ERK signaling , and caused a concentration dependent inhibition of cell proliferation induced by cAMP , epidermal growth factor , or the combination of the two agonists . Negative_regulation YWHAB MAP2K6 12364324 1019031 GLP1 stimulated activation of Erk is blocked by inhibitors of , but GLP1 does not *induce* the activation of A-Raf , [B-Raf] , C-Raf , or Ras . Negative_regulation ZBTB17 CCND1 16537485 1536656 Both down-regulation and the G ( 1 ) slowdown induced by the transposase *require* [Miz-1] . Negative_regulation ZFP36 EPHB2 17606294 1842194 These data establish that [TTP] mediated TNF-alpha mRNA decay is *inhibited* by the combined activation of and p38 and not by p38 activation alone . Negative_regulation ZFP36 EPHB2 21593445 2470243 Constitutive activity *induces* downregulation of [tristetraprolin] , a major protein controlling interleukin8/CXCL8 mRNA stability in melanoma cells . Negative_regulation ZFP36 TNF 14638848 1176701 IL-4-Stat6 signaling induces [tristetraprolin] expression and *inhibits* production in mast cells . Negative_regulation ZFP36 TNF 21611196 2436183 Conversely , transfection of miR-346 in LPS activated THP-1 cells increased [TTP] mRNA expression and *inhibited* release . Negative_regulation ZFP57 BMP2 20392215 2240249 [Zfp521] expression is *inhibited* by and stimulated by parathyroid hormone related protein . Negative_regulation ZFP57 EBF1 18338816 1931954 Finally , we demonstrate that deficiency also *results* in reduced expression of another striatonigral-specific transcription factor , [zinc finger binding protein 521 (Zfp521)] , which is a known Ebf1 functional partner . Negative_regulation ZFP57 EPCAM 17186549 1724604 Overall , [ZFP-TFs] are versatile bi-directional modulators of gene expression and downregulation of promoter activity using ZFP-TFs can ultimately *result* in a novel anti-cancer treatment . Negative_regulation ZFP57 MYLIP 20223197 2223565 directly *represses* the expression of PDGFRalpha , Sox6 , FoxJ3 , and [ZFP238] proteins , all of which normally help to promote OPC proliferation . Negative_regulation ZFP57 STAT3 15845352 1398577 We also found that forced expression of a dominant negative mutant of or repression of Oct-3/4 expression *led* to down-regulation of [Zfp-57] . Negative_regulation ZGLP1 MAP2K6 12364324 1019045 GLP1 stimulated activation of Erk is blocked by inhibitors of , but [GLP1] does not *induce* the activation of A-Raf , B-Raf , C-Raf , or Ras . Negative_regulation ZGLP1 TNF 12850280 1109346 okadaic acid ( PP-2A inhibitor ) was ineffective , while ( PP-1 inhibitor ) blocked the action of insulin and *reduced* that of [GLP-1] ; Negative_regulation ZIC2 JUN 11927148 926834 This is also supported by the fact that does not *inhibit* expression of the neural initializing gene [Zic-r1] but the neural cofactor Sox2 , and that ectopic expression of Sox2 attenuates the anti neuralizing effect of c-Jun . Negative_regulation ZNF382 EPHB2 12720544 1106469 Infection of cells with adenoviruses encoding dominant negative PKCdelta or epsilon inhibited the activation of extracellular-signal regulated kinase ( ) by PE , and also *inhibited* the activation and/or phosphorylation of [S6Ks 1] and 2 . Negative_regulation ZNF750 TP63 22922031 2666727 Restoring ZNF750 to AEC model tissue rescued activator expression and differentiation , indicating that AEC mediated [ZNF750] *inhibition* contributes to differentiation defects in AEC . Negative_regulation ZWINT TNF 22025632 2508061 This abbreviated mitotic phase is correlated with a *induced* reduction in the [kinetochore] localization of MAD2 during prometaphase which , again , can be reversed by inhibiting FAT10 gene expression . Positive_regulation A2M TNS1 6085010 44463 It appears that is a sensitive probe for monitoring protease induced but not methylamine *induced* conformational changes in bovine [alpha 2M] . Positive_regulation A4GALT TNF 15633106 1362517 SB203580 , a specific inhibitor of p38 MAPK , reduced TNF stimulated Stx cytotoxicity in HBECs , *stimulated* ( 125 ) Stx-1 binding to intact HBECs , the cellular content of Gb3 ( galactose alpha 1,4 , galactose ss 1,4 , glucose-ceramide ) ( the Stx receptor ) , and TNF stimulated [Gb3 synthase] and glucosylceramide synthase activities but did not affect lactosylceramide synthase activities or mRNA content . Positive_regulation AAAS NES 9371762 466109 A functional is *required* for active export , presumably by interacting directly or indirectly with the [nuclear pore complex] . Positive_regulation ABCA1 CAPN8 18211896 1895488 The findings suggest annexin 2 externalization is coupled to lipid efflux in prostate epithelium and that IFNgamma induces down-regulation of the protease binding anx2 ( t ) scaffold at the cell surface and consequently acts to suppress invasiveness through *mediated* degradation of the lipid transporter [ABCA1] . Positive_regulation ABCA1 CAPN8 20395597 2273867 The activity of [ABCA1] is *regulated* through proteolysis by . Positive_regulation ABCA1 CAPN8 23835648 2854269 However , the decreased protein stability of [ABCA1] by P. gingivalis LPS was a *result* of increased activity . Positive_regulation ABCA1 IL1B 15769938 1417138 Sirolimus overrode the suppression of cholesterol efflux and [ABCA1] gene expression *induced* by the inflammatory cytokine . Positive_regulation ABCA1 IL1B 17135302 1716735 In addition , IL-1beta could induce the production of reactive oxygen species ( ROS ) , and N-acetyl-L-cysteine , a scavenger of ROS , reversed the decreased level of [ABCA1] *induced* by . Positive_regulation ABCA1 IL1B 17322416 1747761 Sirolimus also increased [ABCA1] and ABCG1 genes expression , even in the *presence* of . Positive_regulation ABCA1 TNF 16492740 1535157 *induces* [ABCA1] through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells . Positive_regulation ABCA1 TNF 16492740 1535162 The *induction* of [ABCA1] by is reduced by 65 % in IkappaB kinase beta-deficient macrophages and by 30 % in p38alpha-deficient macrophages , but not in jun kinase 1 (JNK1)- or JNK2-deficient macrophages . Positive_regulation ABCA1 TNF 18155667 1862693 The expression of [ABCA1] was *increased* by 5 ng/ml or 10 ng/ml compared with control group , and was inhibited by 20 ng/ml TNF-alpha . Positive_regulation ABCA1 TNF 19913791 2224830 Here we examined the *role* of in [ABCA1] induction and tested the effects of lymphotoxin-alpha (LT) , another TNF family member , on macrophage ABCA1 levels . Positive_regulation ABCA1 TNF 19913791 2224833 We studied TNFR2 ( -/- ) and TNFR1 ( -/- ) /R2 ( -/- ) mice and found that both receptors are necessary for maximal *induction* of [ABCA1] by . Positive_regulation ABCA1 TNF 19913791 2224834 *requires* both of its receptors to maximally induce [ABCA1] . Positive_regulation ABCA12 CDKN1C 21769918 2494978 Further , silence of not only decreased the interaction between p57(kip2) and LIMK-1 assayed by immunoprecipitation but also *reduced* the level of [phospho-LIMK1/2] . Positive_regulation ABCA12 MT-CO3 24325322 2899489 *allows* for 4 [Li2O] and 3Co to form , and has a theoretical capacity of 890 mAhg ( -1 ) . Positive_regulation ABCA12 PPARD 17611579 1842206 Here we report that both activators markedly *stimulate* [ABCA12] mRNA expression in cultured human keratinocyte (CHK) in a dose- and time dependent manner . Positive_regulation ABCA12 PPARG 17611579 1842207 Here we report that both and -beta/delta activators markedly *stimulate* [ABCA12] mRNA expression in cultured human keratinocyte (CHK) in a dose- and time dependent manner . Positive_regulation ABCA4 ADO 17885998 1797398 only *initiates* [RMP] with tissue bath exposure , but at low concentrations ( 10 ( -8 ) M ) . Positive_regulation ABCA4 FGFR3 366554 8258 Using intracellular microelectrodes , [resting membrane potential (RMP)] and depolarisation in *response* to added to the bathing medium were recorded in endplate-free regions of the muscle fibres . Positive_regulation ABCA4 HSPG2 16885524 1625613 However , the D ( 2 ) R effects on inward rectification and [RMP] were *blocked* by inhibition of , but not PKA activity . Positive_regulation ABCA4 IFNG 11809739 906508 Interestingly , *induced* [RMp] and augmented NO generation with decreased production of IL-6 , whilst IL-4 induced OMp and augmented IL-6 production . Positive_regulation ABCA4 IL12A 19994586 2174490 The beta-1,3-glucan , lentinan , *induces* [reductive macrophages (RMp)] with elevated intracellular glutathione ( icGSH ) , essential for the secretion of the Th 1-type cytokine , . Positive_regulation ABCA4 IL12B 19994586 2174491 The beta-1,3-glucan , lentinan , *induces* [reductive macrophages (RMp)] with elevated intracellular glutathione ( icGSH ) , essential for the secretion of the Th 1-type cytokine , . Positive_regulation ABCA4 IL2 11809739 906520 CD4 ( + ) CD44 ( - ) naive T ( h ) 0 cells were differentiated preferentially either to T ( h ) l or T ( h ) 2 cells , depending on the presence of [RMp] or OMp during the initial 24 h of culture , from ovalbumin-specific TCR-transgenic mouse spleen cells in the *presence* of . Positive_regulation ABCA4 IL4 11809739 906509 Interestingly , IFN-gamma *induced* [RMp] and augmented NO generation with decreased production of IL-6 , whilst induced OMp and augmented IL-6 production . Positive_regulation ABCA4 IL4 8425228 210961 Both soluble and membrane bound epsilon [RMP] can induce purified splenic B cells to secrete IgE in the *presence* of even without lipopolysaccharide (LPS) . Positive_regulation ABCA4 IL6 11809739 906510 Interestingly , IFN-gamma *induced* [RMp] and augmented NO generation with decreased production of IL-6 , whilst IL-4 induced OMp and augmented production . Positive_regulation ABCA4 IL6 18591233 1946945 However , contrarily to nMP65 , [rMP65] did not *induce* tumor necrosis factor alpha and release from these cells . Positive_regulation ABCA4 OMP 11809739 906511 Interestingly , IFN-gamma *induced* [RMp] and augmented NO generation with decreased production of IL-6 , whilst IL-4 induced and augmented IL-6 production . Positive_regulation ABCA4 PRKACB 16856152 1607181 This study provides evidence that the heterogeneous [RMP] of mature astrocytes is *regulated* by cAMP and signaling . Positive_regulation ABCA4 PRKACG 16856152 1607182 This study provides evidence that the heterogeneous [RMP] of mature astrocytes is *regulated* by cAMP and signaling . Positive_regulation ABCA4 PRKAR1A 16856152 1607183 This study provides evidence that the heterogeneous [RMP] of mature astrocytes is *regulated* by cAMP and signaling . Positive_regulation ABCA4 PRKAR1B 16856152 1607184 This study provides evidence that the heterogeneous [RMP] of mature astrocytes is *regulated* by cAMP and signaling . Positive_regulation ABCA4 PRKAR2A 16856152 1607185 This study provides evidence that the heterogeneous [RMP] of mature astrocytes is *regulated* by cAMP and signaling . Positive_regulation ABCA4 PRKAR2B 16856152 1607186 This study provides evidence that the heterogeneous [RMP] of mature astrocytes is *regulated* by cAMP and signaling . Positive_regulation ABCA7 CAPN8 20495215 2301195 Similar to ABCA1 , ABCA7 was degraded , likely by , and apoA-I and apoA-II *stabilize* [ABCA7] against degradation . Positive_regulation ABCB1 FOXO1 18390843 1951285 *Role* of activation in [MDR1] expression in adriamycin-resistant breast cancer cells . Positive_regulation ABCB1 FOXO1 18390843 1951287 Reporter gene assays showed that the transcription of [MDR1] gene is *stimulated* by overexpression . Positive_regulation ABCB1 FOXO1 18390843 1951289 In conclusion , is a novel transcriptional *activator* of [MDR1] and is crucial for MDR1 induction in MCF-7/ADR cells . Positive_regulation ABCB1 MX2 10070877 594291 The *induction* of [MDR1] mRNA expression by IDA , and 5-FU was analysed by Northern blotting and semiquantitatively assessed by scanning Northern blots on a phosphorimager . Positive_regulation ABCB1 MX2 10070877 594292 Both IDA and *induced* [MDR1] expression within 4 h. 5-FU up-regulated MDR1 expression only when drug exposure was prolonged to 24 h. Based on MRK 16 binding , flow cytometric analysis of P-glycoprotein (Pgp) expression paralleled the increase in MDR1 mRNA levels . Positive_regulation ABCB1 PTGER2 16415092 1533848 The *role* of dependent signaling via cAMP in [Mdr1b] gene activation in primary rat hepatocyte cultures . Positive_regulation ABCB1 TNF 11391531 822928 *Induction* of [Mdr1b] expression by in rat liver cells is independent of p53 but requires NF-kappaB signaling . Positive_regulation ABCB1 TNF 11391531 822936 We aimed to elucidate the mechanism of *up-regulation* of [Mdr1b] by . Positive_regulation ABCB1 TNF 11391531 822945 In conclusion our results show that *activation* of the rat [Mdr1b] gene by is a result of NF-kappaB signaling and independent of p53 . Positive_regulation ABCC1 FOXO1 23763570 2882286 The proximal promoter region of the human MRP2 gene contains four putative FoxO binding sites , and [MRP2] gene transcription was *stimulated* by overexpression in MCF-7 cells . Positive_regulation ABCC1 PDZK1 24436471 2927058 When expressed in HEK293 cells , *increased* membrane expression of [MRP4] by reducing internalization of cell surface MRP4 and consequently , augmented MRP4 mediated efflux of adefovir , a nucleoside based antiviral agent and well known substrate of MRP4 . Positive_regulation ABCC1 TNF 12837754 1134695 These results indicate that induction of [Mrp3] after BDL is *due* to dependent up-regulation of Lrh-1 . Positive_regulation ABCC1 TNF 22290395 2617483 Furthermore , and transforming growth factor-ß1 *induced* the expression of Lpcat2/4 and [Abcc1/4] and down-regulated Slc10a1 and Slco1a1 in primary hepatocytes , suggesting an association between the changes in serum LPC and bile acids and proinflammatory cytokines . Positive_regulation ABCC1 TNF 9182980 436382 In transfected cells , the endogenous production of reduced LRP gene expression ( both messenger RNA and protein ) and *increased* [MRP] gene expression ( both messenger RNA and protein ) , regardless of cell type . Positive_regulation ABCC4 GPR115 25173977 2957562 These findings lead us to propose that [Lkt/ABCC4] mediated PGE2 signalling *acts* through a ciliary , EP4 , to upregulate cAMP synthesis and increase anterograde IFT , thereby promoting ciliogenesis . Positive_regulation ABCC4 GPR132 25173977 2957551 These findings lead us to propose that [Lkt/ABCC4] mediated PGE2 signalling *acts* through a ciliary , EP4 , to upregulate cAMP synthesis and increase anterograde IFT , thereby promoting ciliogenesis . Positive_regulation ABCC4 GPR87 25173977 2957631 These findings lead us to propose that [Lkt/ABCC4] mediated PGE2 signalling *acts* through a ciliary , EP4 , to upregulate cAMP synthesis and increase anterograde IFT , thereby promoting ciliogenesis . Positive_regulation ABCC4 TNF 22290395 2617484 Furthermore , and transforming growth factor-ß1 *induced* the expression of Lpcat2/4 and [Abcc1/4] and down-regulated Slc10a1 and Slco1a1 in primary hepatocytes , suggesting an association between the changes in serum LPC and bile acids and proinflammatory cytokines . Positive_regulation ABCC6 FAS 10226543 610404 [LD-Ara-C] *induced* a slight but consistent increase in the expression of antigen on the treated cells . Positive_regulation ABCC6 TNF 11489729 845378 Long-term stimulation by could *increase* [ARA55] and TIF2 expression in LNCaP cells . Positive_regulation ABCC8 TNF 18854840 2028633 In vitro experiments confirmed that [Abcc8] transcription is *stimulated* by . Positive_regulation ABCG1 CAPN8 21295304 2410278 Here , we show the *role* of in [ABCG1] degradation . Positive_regulation ABCG1 IL1B 17322416 1747762 Sirolimus also increased ABCA1 and [ABCG1] genes expression , even in the *presence* of . Positive_regulation ABCG2 ABCB1 19732497 2134393 Conversely , [ABCG2] expression studied on brain capillaries from MPTP treated mice was decreased ( 1.3-fold , p less than 0.05 ) and expression *increased* ( 1.43-fold , p less than 0.05 ) as an off setting of brain transport . Positive_regulation ABCG2 AHR 20804740 2330535 Here , we demonstrate the dependent *induction* of [ABCG2] expression in human colon adenocarcinoma LS174T cells . Positive_regulation ABCG2 AHR 20804740 2330537 Together , these data show that the novel distal AhRE5 is critical for mediated transcriptional *activation* of [ABCG2] gene expression in LS174T cells , and it may offer new strategies for early identification of ABCG2 inducers , which would be of benefit for preventing transporter associated drug-drug interactions . Positive_regulation ABCG2 AHR 22922104 2678280 [ABCG2] mRNA expression was also *increased* by EGF , oxidative stress or activation of the , while decreased by TGFb . Positive_regulation ABCG2 AHR 24389113 2911999 However , no adequate in vitro model is as yet available to study *dependent* [ABCG2] regulation in dairy animals . Positive_regulation ABCG2 AHR 24389113 2912002 In contrast , activators such as PCB 101 *had* no significant effect on EROD activity , [ABCG2] gene expression or transporter activity . Positive_regulation ABCG2 AKT1 19265662 2045554 This *induced* [ABCG2] activation results from its transport to the plasma membrane . Positive_regulation ABCG2 AKT1 20683952 2299080 We further demonstrate that Oct4 overexpression induced activation of TCL1 , , and [ABCG2] to *mediate* chemoresistance , which can be overcome by addition of the PI3K/AKT inhibitor ; Positive_regulation ABCG2 AKT1 23144836 2699528 In summary , CSC promotes chemoresistance via *mediated* regulation of [ABCG2] activity , and may also increase the proportion of cancer stem-like cells , contributing to tumor resilience . Positive_regulation ABCG2 AKT2 19265662 2045555 This induced [ABCG2] *activation* results from its transport to the plasma membrane . Positive_regulation ABCG2 AKT2 20683952 2299081 We further demonstrate that Oct4 overexpression induced activation of TCL1 , , and [ABCG2] to *mediate* chemoresistance , which can be overcome by addition of the PI3K/AKT inhibitor ; Positive_regulation ABCG2 AKT2 23144836 2699529 In summary , CSC promotes chemoresistance via *mediated* regulation of [ABCG2] activity , and may also increase the proportion of cancer stem-like cells , contributing to tumor resilience . Positive_regulation ABCG2 AKT3 19265662 2045556 This *induced* [ABCG2] activation results from its transport to the plasma membrane . Positive_regulation ABCG2 AKT3 20683952 2299082 We further demonstrate that Oct4 overexpression induced activation of TCL1 , , and [ABCG2] to *mediate* chemoresistance , which can be overcome by addition of the PI3K/AKT inhibitor ; Positive_regulation ABCG2 AKT3 23144836 2699530 In summary , CSC promotes chemoresistance via *mediated* regulation of [ABCG2] activity , and may also increase the proportion of cancer stem-like cells , contributing to tumor resilience . Positive_regulation ABCG2 BAX 21161336 2402058 These changes were associated with down-regulation of the membrane transporter [ABCG2] and attenuation of EGFR , IGF-1R , and NF-?B signaling consistent with inactivation of ß-catenin , COX-2 , c-Myc and Bcl-xL and *activation* of the pro-apoptotic . Positive_regulation ABCG2 BCRP1 16543472 1574610 Complex interaction of [BCRP/ABCG2] and imatinib in BCR-ABL expressing cells : BCRP mediated resistance to imatinib is *attenuated* by imatinib induced reduction of expression . Positive_regulation ABCG2 BCRP2 16543472 1574606 Complex interaction of [BCRP/ABCG2] and imatinib in BCR-ABL expressing cells : BCRP mediated resistance to imatinib is *attenuated* by imatinib induced reduction of expression . Positive_regulation ABCG2 BCRP3 16543472 1574607 Complex interaction of [BCRP/ABCG2] and imatinib in BCR-ABL expressing cells : BCRP mediated resistance to imatinib is *attenuated* by imatinib induced reduction of expression . Positive_regulation ABCG2 BCRP4 16543472 1574608 Complex interaction of [BCRP/ABCG2] and imatinib in BCR-ABL expressing cells : BCRP mediated resistance to imatinib is *attenuated* by imatinib induced reduction of expression . Positive_regulation ABCG2 BCRP5 16543472 1574609 Complex interaction of [BCRP/ABCG2] and imatinib in BCR-ABL expressing cells : BCRP mediated resistance to imatinib is *attenuated* by imatinib induced reduction of expression . Positive_regulation ABCG2 BCRP6 16543472 1574611 Complex interaction of [BCRP/ABCG2] and imatinib in BCR-ABL expressing cells : BCRP mediated resistance to imatinib is *attenuated* by imatinib induced reduction of expression . Positive_regulation ABCG2 BCRP7 16543472 1574612 Complex interaction of [BCRP/ABCG2] and imatinib in BCR-ABL expressing cells : BCRP mediated resistance to imatinib is *attenuated* by imatinib induced reduction of expression . Positive_regulation ABCG2 BCRP8 16543472 1574613 Complex interaction of [BCRP/ABCG2] and imatinib in BCR-ABL expressing cells : BCRP mediated resistance to imatinib is *attenuated* by imatinib induced reduction of expression . Positive_regulation ABCG2 BCRP9 16543472 1574614 Complex interaction of [BCRP/ABCG2] and imatinib in BCR-ABL expressing cells : BCRP mediated resistance to imatinib is *attenuated* by imatinib induced reduction of expression . Positive_regulation ABCG2 BSG 23623923 2810501 We established four MCF-7 cell lines transfected with CD147 and/or ABCG2 and found that could *increase* the expression and dimerization of [ABCG2] , affect its cellular localization and regulate its drug transporter function . Positive_regulation ABCG2 BTRC 22252524 2629530 Upon *stimulation* with or G-CSF , higher levels of CD117 , [ABCG2] , and CD44 were observed in PC-3 and DU145 cells examined by flow cytometry . Positive_regulation ABCG2 CSF3 22252524 2629531 Upon *stimulation* with SCF or , higher levels of CD117 , [ABCG2] , and CD44 were observed in PC-3 and DU145 cells examined by flow cytometry . Positive_regulation ABCG2 CUL1 22252524 2629532 Upon *stimulation* with or G-CSF , higher levels of CD117 , [ABCG2] , and CD44 were observed in PC-3 and DU145 cells examined by flow cytometry . Positive_regulation ABCG2 CYP2C19 24332840 2905167 In LS180 cells , telaprevir strongly induced mRNA expression of [ABCG2] ( 4.3-fold at 30 µmol/L ) and weakly *induced* ABCB11 , and UGT1A3 . Positive_regulation ABCG2 E2F1 24276245 2948815 Here we report that the major multidrug transporter [ABCG2] ( BCRP/MXR ) is directly and specifically *activated* by the -- a factor perturbed in the majority of human cancers . Positive_regulation ABCG2 E2F1 24276245 2948816 *regulates* [ABCG2] expression in multiple cell systems , and , importantly , we have identified a significant correlation between elevated E2F1 and ABCG2 expression in human lung cancers . Positive_regulation ABCG2 EGF 22922104 2678279 [ABCG2] mRNA expression was also *increased* by , oxidative stress or activation of the aryl hydrocarbon receptor , while decreased by TGFb . Positive_regulation ABCG2 EPAS1 22452996 2588632 could *regulate* [ABCG2] in breast cancer cells , and could be a novel potential bio-marker to predict chemotherapy effectiveness . Positive_regulation ABCG2 ERAS 21965746 2488302 induces chemoresistance to CPT-11 via activation of phosphatidylinositol-3 kinase-protein kinase ß mTOR pathway and NF-?B , and consequently *results* in up-regulation of [ABCG2] . Positive_regulation ABCG2 GABPA 20682644 2305718 This study examined the mechanism underlying *dependent* expression of [ABCG2] and its role in the multidrug resistance phenotype . Positive_regulation ABCG2 IL10 20846001 2375422 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL11 20846001 2375423 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL13 20846001 2375424 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL15 20846001 2375425 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL16 20846001 2375426 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL18 20846001 2375427 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL19 20846001 2375428 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL1A 22750628 2659716 In conclusion , and TNF-a *induced* [ABCG2] and PXR expression and NF-?B activity in some breast cancer and normal cell lines . Positive_regulation ABCG2 IL2 20846001 2375429 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL20 20846001 2375430 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL21 20846001 2375431 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL22 20846001 2375414 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL24 20846001 2375411 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL25 20846001 2375413 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL26 20846001 2375418 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL27 20846001 2375419 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL3 20846001 2375432 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL31 20846001 2375420 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL32 20846001 2375417 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL33 20846001 2375416 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL34 20846001 2375421 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL37 20846001 2375415 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL4 11345586 814226 In addition , we report several novel effects of deactivators and infection on the expression of known genes : ( 1 ) *caused* pronounced upregulation of [ABCG2] , coding for an ATP binding cassette transporter highly expressed in the placenta , which mediates multidrug resistance of cancer cells , but is otherwise of unknown function ; Positive_regulation ABCG2 IL4 17825224 1795437 does not *regulate* [ABCG2] expression in human lung adencarcinoma cell lines . Positive_regulation ABCG2 IL4 20846001 2375433 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL5 20846001 2375434 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL6 19333723 2135452 *increased* [ABCG2] protein , but had no effects on ABCG2 mRNA and function in MCF-7 cells . Positive_regulation ABCG2 IL6 20846001 2375435 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL7 20846001 2375436 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL8 20846001 2375437 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 IL9 20846001 2375438 In conclusion , and tumor necrosis factor-a *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 MIR328 19270061 2079716 negatively *regulates* the expression of breast cancer resistance protein ( [BCRP/ABCG2] ) in human cancer cells . Positive_regulation ABCG2 NFE2L2 23650051 2823222 Since patients have demonstrated individual differences in their response to PDT , *mediated* transcriptional activation of the [ABCG2] gene in cancer may affect patients ' responses to PDT as well as chemotherapy . Positive_regulation ABCG2 NOTCH1 19143760 2026098 During injury recovery , disruption of signalling by treatment with the gamma-secretase inhibitor *reduced* expression of ABCG2 and PCNA , but promoted expression of CK19 , while persistent activation of Notch signalling promoted expression of [ABCG2] and PCNA , but reduced expression of CK19 . Positive_regulation ABCG2 NOTCH2 19143760 2026099 During injury recovery , disruption of Notch signalling by treatment with the gamma-secretase inhibitor reduced expression of ABCG2 and PCNA , but promoted expression of CK19 , while persistent activation of signalling *promoted* expression of [ABCG2] and PCNA , but reduced expression of CK19 . Positive_regulation ABCG2 NOTCH3 19143760 2026100 During injury recovery , disruption of signalling by treatment with the gamma-secretase inhibitor *reduced* expression of ABCG2 and PCNA , but promoted expression of CK19 , while persistent activation of Notch signalling promoted expression of [ABCG2] and PCNA , but reduced expression of CK19 . Positive_regulation ABCG2 NOTCH4 19143760 2026101 During injury recovery , disruption of Notch signalling by treatment with the gamma-secretase inhibitor reduced expression of ABCG2 and PCNA , but promoted expression of CK19 , while persistent activation of signalling *promoted* expression of [ABCG2] and PCNA , but reduced expression of CK19 . Positive_regulation ABCG2 NR1I2 23123212 2717549 *upregulates* ABC-transporter [Abcg2] and Abcb1 at the blood-brain barrier . Positive_regulation ABCG2 NR1I3 23340159 2747347 *upregulates* Abcb1 and [Abcg2] at the blood-brain barrier after CITCO activation . Positive_regulation ABCG2 POU5F1 20683952 2299083 We further demonstrate that overexpression induced activation of TCL1 , AKT , and [ABCG2] to *mediate* chemoresistance , which can be overcome by addition of the PI3K/AKT inhibitor ; Positive_regulation ABCG2 PPARG 16785230 1599417 We confirmed the binding of the PPARgamma x RXR heterodimer to this enhancer region , suggesting that directly *regulates* the transcription of [ABCG2] . Positive_regulation ABCG2 PRL 23150485 2729612 We investigated the *role* of the lactogenic hormone in the regulation of [ABCG2] . Positive_regulation ABCG2 PRL 23150485 2729614 dose-dependently *induced* [ABCG2] expression in T-47D human breast cancer cells . Positive_regulation ABCG2 PRL 23150485 2729616 Knockdown or pharmacologic inhibition of the down-stream signal transducer and activator of transcription-5 ( STAT5 ) also blunted the *induction* of [ABCG2] by , suggesting a role for the JAK2/STAT5 pathway in PRL induced ABCG2 expression . Positive_regulation ABCG2 PRL 23150485 2729618 Interestingly , inhibitors against the mitogen activated protein kinase and phosphoinositide-3-kinase signaling pathways significantly decreased the *induction* of [ABCG2] by without altering STAT5 recruitment to the GAS element . Positive_regulation ABCG2 PRL 23150485 2729619 We conclude that the JAK2/STAT5 pathway is required but not sufficient for the *induction* of [ABCG2] by . Positive_regulation ABCG2 SKP1 22252524 2629529 Upon *stimulation* with or G-CSF , higher levels of CD117 , [ABCG2] , and CD44 were observed in PC-3 and DU145 cells examined by flow cytometry . Positive_regulation ABCG2 SLC17A5 24747122 2939298 Moreover , *stimulated* the ATPase activity of [ABCG2] . Positive_regulation ABCG2 SP3 23996530 2856094 The [ABCG2] promoter activity was impaired when Sp1 sites were mutated but was *enhanced* by overexpression of Sp1 or proteins . Positive_regulation ABCG2 SP3 23996530 2856095 Moreover , inhibiting Sp1- or *dependent* [ABCG2] expression caused chemosensitization to the anticancer drug cisplatin . Positive_regulation ABCG2 SPP1 23935934 2826766 Furthermore , host *induces* VEGF , [ABCG2] and ERK1/2 expression and activation in B16-WT cells . Positive_regulation ABCG2 SPR 9176265 433707 Inclusion of SPR210 antibodies blocked association of SP-A-BCG complexes , suggesting a *role* for in mediating the interaction of [SP-A-BCG] with the macrophages . Positive_regulation ABCG2 TNF 20846001 2375412 In conclusion , interleukin-1ß and *induced* [ABCG2] and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation ABCG2 TNF 22750628 2659715 In conclusion , IL-1ß and *induced* [ABCG2] and PXR expression and NF-?B activity in some breast cancer and normal cell lines . Positive_regulation ABCG2 TP53 19107196 2004135 The present work demonstrated that [ABCG2] protects ES cells from PPIX accumulation during colony expansion , and that and gammaH2AX *acts* as a downstream checkpoint of ABCG2 dependent defense machinery in order to maintain the self-renewal of ES cells . Positive_regulation ABCG2 UGT1A3 24332840 2905166 In LS180 cells , telaprevir strongly induced mRNA expression of [ABCG2] ( 4.3-fold at 30 µmol/L ) and weakly *induced* ABCB11 , CYP2C19 and . Positive_regulation ABI1 CAPN8 15178460 1255337 Pak regulates *dependent* degradation of [E3b1] . Positive_regulation ABI1 CAPN8 15178460 1255386 Here we present evidence that [E3b1] levels are *regulated* by the Ca ( 2+ ) -activated protease , and also by Pak , a downstream target of Rac signaling . Positive_regulation ABL1 EPHB2 11494128 846129 Activated *causes* tyrosine phosphorylation of [Abl] and Arg , and vice versa . Positive_regulation ABL1 EPHB2 8524249 335108 These results suggest that both Crk and Grb2 may contribute to the *activation* of by oncogenic [Abl] , whereas Nck is unlikely to participate in this pathway . Positive_regulation ABL1 FAS 9680367 521040 *mediated* modulation of [Bcr/Abl] in chronic myelogenous leukemia results in differential effects on apoptosis . Positive_regulation ABL1 GPR115 16291747 1510491 We performed in vitro kinase activity assays and show that [BCR-ABL] also leads to increased p110gamma activity and that this activation *requires* both and Ras signaling . Positive_regulation ABL1 GPR132 16291747 1510480 We performed in vitro kinase activity assays and show that [BCR-ABL] also leads to increased p110gamma activity and that this activation *requires* both and Ras signaling . Positive_regulation ABL1 GPR87 16291747 1510560 We performed in vitro kinase activity assays and show that [BCR-ABL] also leads to increased p110gamma activity and that this activation *requires* both and Ras signaling . Positive_regulation ABL1 MAP2K6 10570156 568122 Our study suggests that c-Abl is required for DNA damage induced MKK6 and p38 activation , and that *activation* of by [c-Abl] is required for c-Abl induced apoptosis but not c-Abl induced cell cycle arrest . Positive_regulation ABL1 PECAM1 23233201 2724497 is *involved* in [BCR/ABL] signaling and may downregulate imatinib induced apoptosis of Philadelphia chromosome positive leukemia cells . Positive_regulation ABL1 TNF 15121862 1242165 In cells expressing a degradation-resistant RB protein ( RB-MI ) , does not *activate* [c-ABL.] RB-MI also inhibits TNF-alpha mediated activation of p73 . Positive_regulation ACACA CCND1 14714130 1347039 To evaluate the *role* of in the biological regulation of [ACC] , we constitutively expressed an antisense cyclin D1 complementary DNA ( cDNA ) in an established ACC cell line that exhibits high endogenous expression of cyclin D1 . Positive_regulation ACACA PGC 21803289 2462280 Deletion of mIndy in mice ( mINDY ( -/- ) mice ) reduces hepatocellular ATP/ADP ratio , activates hepatic AMPK , *induces* , inhibits [ACC-2] , and reduces SREBP-1c levels . Positive_regulation ACACA TNF 17222972 1703648 In the present study , we examined TNF-alpha expression in the mouse ACC following hind-paw administration of complete Freund's adjuvant (CFA) and examined the *role* of in [ACC] synaptic transmission . Positive_regulation ACAD8 EPHB2 19755425 2158609 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Positive_regulation ACADM PGC 12522104 1063977 In support of this hypothesis , adenovirus mediated delivery of small interfering RNA for ERRalpha , or of PGC-1 mutants that interact selectively with different types of nuclear receptors , shows that can *induce* the fatty acid oxidation enzyme [MCAD] ( medium-chain acyl-coenzyme A dehydrogenase ) in an ERRalpha dependent manner . Positive_regulation ACAN ADAMTS1 22562232 2591349 Despite this regulation of ADAMTS , no formation of NITEGE neoepitopes occurred in MSC pellets , indicating no *induced* cleavage of [aggrecan] . Positive_regulation ACAN ADAMTS1 22562232 2591395 Submission of differentiated MSC pellets to IL1ß treatment for 3 d resulted in strong upregulation of ADAMTS1 , 4 and 5 , rapid proteoglycan depletion , and stimulation of induced but not MMP *induced* cleavage of [aggrecan] . Positive_regulation ACAN CTGF 12811819 1102905 Furthermore , *stimulated* gene expression of the [aggrecan] gene , as well as DNA/proteoglycan synthesis , was diminished when HCS-2/8 cells were pretreated with heparinase , indicating that the effects of CTGF/Hcs24 on chondrocytes occurred through the interaction between CTGF/Hcs24 and heparan sulfate on the cells . Positive_regulation ACAN CTGF 21928342 2539151 In this study we demonstrate that Wif-1 is capable to interfere with dependent *induction* of [Acan] and Col2a1 gene expression in primary murine chondrocytes . Positive_regulation ACAN EPHB2 16622376 1551688 Moreover , inhibition of activity , in the presence TGF-beta3 , *resulted* in suppression of collagen Type II , [aggrecan] , TGF-beta-RI , TGF-beta-RII and TGF-beta-RIII mRNA expression . Positive_regulation ACAN EPHB2 19823173 2187259 Selective inhibition of and Rho/ROCK activation greatly reduced or completely *prevented* excess type II collagen and [aggrecan] degradation in response to TGFalpha . Positive_regulation ACAN IL1B 11174072 763233 *induces* different gene expression of stromelysin , [aggrecan] and tumor-necrosis-factor stimulated gene 6 in human osteoarthritic chondrocytes in vitro . Positive_regulation ACAN IL1B 11467894 840811 *induced* changes in CAM [aggrecan] and hyaluronan closely agreed . Positive_regulation ACAN IL1B 12746901 1088823 However , IGF-1 was able to reverse *mediated* degradation of [aggrecan] and the repression of the aggrecan synthesis rate . Positive_regulation ACAN IL1B 17337215 1740922 GlcN treatment partially blocked *mediated* downregulation of collagen II and [aggrecan] expression and inhibited expression of the matrix degrading enzyme , matrix metalloproteinase 13 (MMP-13) , in both chondrocytes and hMSCs undergoing chondrogenesis . Positive_regulation ACAN MAP2K6 19823173 2187265 Selective inhibition of and Rho/ROCK activation greatly reduced or completely *prevented* excess type II collagen and [aggrecan] degradation in response to TGFalpha . Positive_regulation ACAN MMP28 12890681 1157276 A selective inhibitor did not *block* [aggrecan] degradation but caused complete inhibition of collagen breakdown . Positive_regulation ACAN MMP28 16997584 1682757 MMP and *mediated* release of [aggrecan] and its fragments from articular cartilage : a comparative study of three different aggrecan and glycosaminoglycan assays . Positive_regulation ACAN MMP28 18513402 1939659 Cartilage degradation was measured by *mediated* type II collagen degradation ( CTX-II ) , and MMP and aggrecanase mediated [aggrecan] degradation by detecting the 342FFGVG and 374ARGSV neoepitopes . Positive_regulation ACAN MMP28 19248107 2045047 APC stimulated [aggrecan] and collagen breakdown were *due* to activity but were not associated with modulation of MMP , ADAMTS , or TIMP expression . Positive_regulation ACAN MMP28 20714280 2381228 The shift from aggrecanase to MMP induced degradation products with dynamic compression overloading suggests that protein degradation and loss can precede major structural disruption in the IVD , and that *induced* [aggrecan] degradation may be a marker of mechanically induced disc degeneration . Positive_regulation ACAN MMP28 21055468 2395585 The analysis of aggrecan IGD degradation in bovine articular cartilage explants treated with catabolic cytokines over a 19-day period showed that *mediated* degradation of [aggrecan] within the IGD can only be observed following day 12 of culture . Positive_regulation ACAN MMP28 22562232 2591361 In contrast , *induced* cleavage of [aggrecan] appeared at 14 d after induction of chondrogenesis . Positive_regulation ACAN MMP28 22562232 2591386 Submission of differentiated MSC pellets to IL1ß treatment for 3 d resulted in strong upregulation of ADAMTS1 , 4 and 5 , rapid proteoglycan depletion , and stimulation of ADAMTS induced but not *induced* cleavage of [aggrecan] . Positive_regulation ACAN MMP7 12890681 1157291 A selective inhibitor did not *block* [aggrecan] degradation but caused complete inhibition of collagen breakdown . Positive_regulation ACAN MMP7 16997584 1682772 MMP and *mediated* release of [aggrecan] and its fragments from articular cartilage : a comparative study of three different aggrecan and glycosaminoglycan assays . Positive_regulation ACAN MMP7 18513402 1939674 Cartilage degradation was measured by *mediated* type II collagen degradation ( CTX-II ) , and MMP and aggrecanase mediated [aggrecan] degradation by detecting the 342FFGVG and 374ARGSV neoepitopes . Positive_regulation ACAN MMP7 19248107 2045063 APC stimulated [aggrecan] and collagen breakdown were *due* to activity but were not associated with modulation of MMP , ADAMTS , or TIMP expression . Positive_regulation ACAN MMP7 20714280 2381243 The shift from aggrecanase to MMP induced degradation products with dynamic compression overloading suggests that protein degradation and loss can precede major structural disruption in the IVD , and that *induced* [aggrecan] degradation may be a marker of mechanically induced disc degeneration . Positive_regulation ACAN MMP7 21055468 2395600 The analysis of aggrecan IGD degradation in bovine articular cartilage explants treated with catabolic cytokines over a 19-day period showed that *mediated* degradation of [aggrecan] within the IGD can only be observed following day 12 of culture . Positive_regulation ACAN MMP7 22562232 2591376 In contrast , *induced* cleavage of [aggrecan] appeared at 14 d after induction of chondrogenesis . Positive_regulation ACAN MMP7 22562232 2591417 Submission of differentiated MSC pellets to IL1ß treatment for 3 d resulted in strong upregulation of ADAMTS1 , 4 and 5 , rapid proteoglycan depletion , and stimulation of ADAMTS induced but not *induced* cleavage of [aggrecan] . Positive_regulation ACAN TF 8689460 343284 The extent to which different growth or differentiation factors were able to restore 35S incorporation in aggrecan in serum-free DMEM was determined : human serum *had* no effect on [aggrecan] synthesis levels ; Positive_regulation ACAN TNF 11174072 763235 Quantitative RT-PCR reaction was used to estimate the messenger RNA ( mRNA ) of three different metabolites [ *stimulated* gene 6 ( TSG-6 ) , stromelysin-1 ( MMP-3 ) and [aggrecan (AGG)] ] . Positive_regulation ACAN TNF 17923423 1888907 Nitric oxide enhances [aggrecan] degradation by aggrecanase in *response* to but not IL-1beta treatment at a post-transcriptional level in bovine cartilage explants . Positive_regulation ACAN TNF 23602832 2789789 Lentiviral transduction with shRNA plasmids shp65 , shp52 , shIKK-a , and shIKK-ß significantly decreased *dependent* increase in ADAMTS-4 and -5 levels and [aggrecan] degradation . Positive_regulation ACAN TNF 23602832 2789794 Silencing of either ADAMTS-4 or -5 resulted in reduction in *dependent* [aggrecan] degradation in NP cells . Positive_regulation ACAP1 IL1B 17005562 1647440 [CENTB1] expression in epithelial cells was highly *induced* by tumor necrosis factor alpha , , and the NOD1 and NOD2 ligands ( gamma-d-glutamyl-meso-diaminopimelic acid and muramyl dipeptide , respectively ) . Positive_regulation ACAT1 TNF 19189937 2071620 *stimulates* the [ACAT1] expression in differentiating monocytes to promote the CE-laden cell formation . Positive_regulation ACAT1 TNF 19189937 2071623 In this article , we show that in cultured , differentiating human monocytes , *enhances* the expression of the [ACAT1] but not ACAT2 gene , increases the cholesteryl ester accumulation , and promotes the lipid-laden cell formation . Positive_regulation ACAT1 TNF 19189937 2071624 Our data demonstrate that , through the NF-kappa B pathway , specifically *enhances* the expression of human [ACAT1] gene to promote the CE-laden cell formation from the differentiating monocytes , and our data support the hypothesis that TNF-alpha is proatherosclerotic during early phase of lesion development . Positive_regulation ACCS JAG1 22427350 2588196 Analysis of clinical data indicates that Jag1 expression correlates with both grade and stage of ACCs , supporting a *role* of dependent Notch activation in late-stage [ACCs] . Positive_regulation ACD EPHB2 12402047 1009418 We conclude that cAMP induced regulation of and *activation* of [Rap1] are independent processes . Positive_regulation ACD EPHB2 20008137 2191207 In contrast , an inhibitor , PD98059 , *reduced* NaAs induced [ACD] in mProx24 cells . Positive_regulation ACD F2R 15078882 1251924 Concomitant stimulation of both and PAR-4 in the presence of ADP scavengers still *resulted* in a strongly reduced activation of [Rap1B] . Positive_regulation ACD FLG 17045653 1666572 Using a Rap1-GTP pull-down assay , we found that stimulation , but not LPS , of avian heterophils *induced* a rapid and transient [Rap1] activation . Positive_regulation ACD FLG 17045653 1666593 We show here that stimulation of heterophils *induces* the phosphorylation of [Rap1] . Positive_regulation ACD ITGAL 24486015 2928146 The gap junction protein connexin43 (Cx43) regulates B lymphocyte adhesion , BCR- and mediated *activation* of the GTPase [Rap1] , and cytoskeletal rearrangements resulting in changes to cell shape and membrane spreading . Positive_regulation ACD PECAM1 10725328 677542 Importantly , selectively *activated* the small Ras related GTPase , [Rap1] , but not Ras , R-Ras , or Rap2 . Positive_regulation ACD TCN1 23406759 2713282 [Allergic contact dermatitis (ACD)] resulting from exposure to low molecular weight chemicals is a common clinical condition in industrialized countries and can be *mediated* by either Th1 or lymphocytes . Positive_regulation ACD TNF 1516597 196791 To elucidate the *role* of in determining [anemia of chronic disease (ACD)] in rheumatoid arthritis ( RA ) , 24 patients were studied for disease parameters , TNF serum levels and bone marrow for erythroid colony growth and compared with six controls . Positive_regulation ACD TNF 22543145 2590361 Mustard seed *inhibits* [ACD] in mice possibly by suppressing the expressions of IL-1ß , and IL-6 mRNA and inhibiting Langerhans cell migration in the epidermis . Positive_regulation ACE ANGPT1 12359982 994884 Circulating ( pro ) renin , angiotensinogen , and ANG II enter the interstitium via diffusion , and interstitial ANG II generation is *mediated* , at least in part , by basolaterally located endothelial [ACE] . Positive_regulation ACE ANGPT1 12811821 1102916 Expression of alpha-smooth muscle ( SM ) actin , apparent in the contractile phenotype , was decreased by FN. Expressions of matrix Gla and osteopontin , apparent in the synthetic phenotype , were increased by FN . Ang II measured by radioimmunoassay ( RIA ) was significantly increased in human VSMC by FN. Expression of mRNAs for Ang II-generating proteases cathepsin D , cathepsin G , [ACE] , and chymase was increased by FN. Expressions of cathepsin D and cathepsin G proteins were also *increased* by FN. activity , which was inhibited by an aspartyl protease inhibitor pepstatin A , was readily detected in the conditioned medium from human VSMC . Positive_regulation ACE ANGPT1 18084722 1882974 Role of ACE/AT2R complex in the control of mesenteric resistance artery contraction induced by [ACE/AT1R] complex activation in *response* to . Positive_regulation ACE EDN2 11078388 749287 *regulates* [angiotensin converting enzyme] in the mouse kidney . Positive_regulation ACE EPHB2 18403595 1899545 The inhibition of ACE2 expression was shown to be associated with [ACE] up-regulation and *activation* of extracellular regulated ( ) 1/2 and p38 mitogen activated protein ( MAP ) kinases . Positive_regulation ACE MYH16 17188239 1680001 On the other hand , overexpression of [ACE] *induced* the down-regulation of . Positive_regulation ACE MYH16 17892857 1802597 Overexpression of [ACE] *induced* the down-regulation of , a late myogenic marker at 3-5 days after induction of differentiation . Positive_regulation ACE MYH3 17188239 1680008 On the other hand , overexpression of [ACE] *induced* the down-regulation of . Positive_regulation ACE MYH3 17892857 1802604 Overexpression of [ACE] *induced* the down-regulation of , a late myogenic marker at 3-5 days after induction of differentiation . Positive_regulation ACE SELL 1731039 181343 and 7 ) is a highly potent antagonist infused either IMA or i.v. , and its antagonist properties do not *require* [ACE] . Positive_regulation ACE TNF 19537595 2098980 Much attention is paid to perspectives of [ACE] *inhibitors* , angiotensin II receptor blockers , statins , inhibitors in prevention of cardiovascular complication in RA Positive_regulation ACE2 ANGPT1 22749485 2715491 We tested the hypothesis that [ACE2] is *increased* in diabetic peripheral atheroma , concomitantly with , angiotensin II receptor 1 ( AT1R ) , proinflammatory cytokines , macrophage infiltration , and plaque neovascularization . Positive_regulation ACE2 IL1B 19411314 2095743 Phorbol ester , ionomycin , endotoxin , and and TNFalpha acutely *induced* [ACE2] release , further supporting that ADAM17 and ADAM10 regulate ACE2 cleavage . Positive_regulation ACE2 TNF 19411314 2095742 Phorbol ester , ionomycin , endotoxin , and IL-1beta and acutely *induced* [ACE2] release , further supporting that ADAM17 and ADAM10 regulate ACE2 cleavage . Positive_regulation ACHE CAPN8 17320203 1711713 In the present study , we show that activated , a cytosolic calcium activated cysteine protease , and calcineurin , a calcium dependent protein phosphatase , *regulate* [acetylcholinesterase] expression during A23187 induced apoptosis . Positive_regulation ACHE IL1B 8299737 248567 Similarly , both Epo and IL-6 , but not , *increased* the [acetylcholinesterase (AchE)] activity in the megakaryocytes . Positive_regulation ACHE NT5E 9822749 548958 These results demonstrate that and BDNF *stimulate* [AChE] gene expression in motoneurons and support the concept that muscle derived trkB ligands modulate the cholinergic phenotype of their innervating motoneurons . Positive_regulation ACLY PGC 21914785 2501627 In addition , SLC25A1 and [ACLY] , which are required for the conversion of glucose into acetyl-CoA for fatty acid synthesis , were also *increased* by , thus linking the oxidative and lipogenic functions of PGC1a . Positive_regulation ACLY TNF 23490076 2895514 Our purpose was to determine the different expressions of the LOXs in poorly self healing [anterior cruciate ligament (ACL)] and well functionally self healing medial collateral ligament ( MCL ) *induced* by . Positive_regulation ACO2 IL1B 9389514 467136 Treatment of rat islets for 18 h with *results* in an inhibition of glucose stimulated insulin secretion , mitochondrial [aconitase] activity , and total protein synthesis . Positive_regulation ACP1 CTGF 18751416 1956332 Consistent with these results , recombinant human ( rCCN2 ) *stimulated* tartrate-resistant [acid phosphatase] ( TRAP ) -positive osteoclast-like cell formation in vitro . Positive_regulation ACP1 NT5E 22439427 2573500 Alkaline phosphatase and [acid phosphatase] activities were *detected* in many organs and tissues , while the activities of adenosine triphosphatase , <5'-nucleotidase> and glucose-6-phosphatase were restricted to a few organs . Positive_regulation ACP1 TNF 23238125 2731759 In addition , the ability of bone marrow derived monocytes/macrophages from the siglec-15 ( -/- ) mice to differentiate into osteoclasts was impaired , as determined in vitro by cellular tartrate-resistant [acid phosphatase] activity in *response* to the receptor activator of nuclear factor-?B ligand or . Positive_regulation ACP2 CTGF 18751416 1956333 Consistent with these results , recombinant human ( rCCN2 ) *stimulated* tartrate-resistant [acid phosphatase] ( TRAP ) -positive osteoclast-like cell formation in vitro . Positive_regulation ACP2 IL1B 17348037 1741078 All three stimuli increased PGHS-2 and IL-8 mRNA expression in a MAPK dependent manner , but while the MAPK inhibitors reduced the induced *activation* of activating transcription factor (ATF)-2 , [liver activating protein (LAP)] and c-jun , the stretch induced increase in LAP was unaffected by MAPK-inhibition and only JNK inhibition appeared to reduce c-jun activation . Positive_regulation ACP2 NT5E 22439427 2573502 Alkaline phosphatase and [acid phosphatase] activities were *detected* in many organs and tissues , while the activities of adenosine triphosphatase , <5'-nucleotidase> and glucose-6-phosphatase were restricted to a few organs . Positive_regulation ACP2 TNF 23238125 2731760 In addition , the ability of bone marrow derived monocytes/macrophages from the siglec-15 ( -/- ) mice to differentiate into osteoclasts was impaired , as determined in vitro by cellular tartrate-resistant [acid phosphatase] activity in *response* to the receptor activator of nuclear factor-?B ligand or . Positive_regulation ACP2 TNF 9576761 502870 An increase in *dependent* nuclear expression of CCAAT/enhancer binding protein-beta ( C/EBP-beta ) [/liver enriched activating protein (LAP)] was detected after 1 h , whereas an increase in RNA expression was evident only after 4 h. C/EBP-beta/LAP expression returned to normal values before progression into the S-phase . Positive_regulation ACP5 CTGF 18751416 1956334 Consistent with these results , recombinant human ( rCCN2 ) *stimulated* tartrate-resistant [acid phosphatase] ( TRAP ) -positive osteoclast-like cell formation in vitro . Positive_regulation ACP5 NT5E 22439427 2573504 Alkaline phosphatase and [acid phosphatase] activities were *detected* in many organs and tissues , while the activities of adenosine triphosphatase , <5'-nucleotidase> and glucose-6-phosphatase were restricted to a few organs . Positive_regulation ACP5 TNF 23238125 2731761 In addition , the ability of bone marrow derived monocytes/macrophages from the siglec-15 ( -/- ) mice to differentiate into osteoclasts was impaired , as determined in vitro by cellular tartrate-resistant [acid phosphatase] activity in *response* to the receptor activator of nuclear factor-?B ligand or . Positive_regulation ACP6 CTGF 18751416 1956335 Consistent with these results , recombinant human ( rCCN2 ) *stimulated* tartrate-resistant [acid phosphatase] ( TRAP ) -positive osteoclast-like cell formation in vitro . Positive_regulation ACP6 NT5E 22439427 2573506 Alkaline phosphatase and [acid phosphatase] activities were *detected* in many organs and tissues , while the activities of adenosine triphosphatase , <5'-nucleotidase> and glucose-6-phosphatase were restricted to a few organs . Positive_regulation ACP6 TNF 23238125 2731762 In addition , the ability of bone marrow derived monocytes/macrophages from the siglec-15 ( -/- ) mice to differentiate into osteoclasts was impaired , as determined in vitro by cellular tartrate-resistant [acid phosphatase] activity in *response* to the receptor activator of nuclear factor-?B ligand or . Positive_regulation ACPP EPHB2 18084034 1868388 This [PAP] activity was also *activated* by stimulation of with phorbol-12-myristate-13-acetate in vivo . Positive_regulation ACSS1 ACLY 22718913 2659541 Furthermore , suppression *resulted* in elevated expression of [acyl-CoA synthetase short-chain family] member 2 ( ACSS2 ) , an enzyme that also produces acetyl-CoA using acetate as a substrate . Positive_regulation ACSS1 INS 22275878 2545259 We show that multiple [ACSs] are also transcriptionally *regulated* by signaling in mammalian cells . Positive_regulation ACSS1 KLF15 14960588 1235345 Furthermore , overexpression *induced* the levels of [AceCS2] transcripts both in myoblasts and in myotubes , indicating that AceCS2 gene expression in vivo is indeed induced by KLF15 . Positive_regulation ACSS2 EDN2 9230761 444747 To investigate the *role* of the endothelial derived vasoactive mediator ( ET-1 ) in the [acute chest syndrome (ACS)] , we incubated bovine pulmonary artery endothelial cells ( BPAEC ) with red blood cells ( equivalent to a hematocrit of 20 % ) and/or autologous plasma ( 1 : 10 dilution ) from two patients during ACS and during routine clinic visits . Positive_regulation ACTB FAS 17394485 1721058 Finally , in *response* to receptor activation or staurosporine treatment the levels of [beta-actin] or alpha-tubulin remained unaltered , whereas several Golgi proteins , p115 and golgin-160 , underwent caspase mediated cleavage . Positive_regulation ACTB IL1B 16847181 1588121 The messenger RNA expressions of [LARC] ( liver and activation regulated chemokine ) , GMCSF ( granulocyte-macrophage colony stimulating factor ) , epiregulin , ICAM1 ( intercellular adhesion molecule 1 ) , and TGFA ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation ACTB IL1B 9756297 535729 Blastomeres from 12 embryos were examined : [beta-actin] and IL-1R type I mRNA were *detected* in all blastomeres ( 100 % ) whereas could be detected in only nine of the blastomeres ( 75 % ) . Positive_regulation ACTB TNF 12192035 980750 Here we report that even though NF-kappaB interacts directly with TAF(II)s , induction of NF-kappaB by does not *enhance* TFIID recruitment and [preinitiation complex] formation on some NF-kappaB-responsive promoters . Positive_regulation ACTB TNF 17766589 1822808 We tested the hypothesis that *induces* barrier dysfunction of pulmonary microvessel endothelial monolayers ( PMEM ) mediated by specific tyrosine residues in [beta-actin] . Positive_regulation ACTL6A IL1B 16847181 1588125 The messenger RNA expressions of [LARC] ( liver and activation regulated chemokine ) , GMCSF ( granulocyte-macrophage colony stimulating factor ) , epiregulin , ICAM1 ( intercellular adhesion molecule 1 ) , and TGFA ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation ACTL6A MAP2K6 15208625 1268010 The SWI-SNF subunit [BAF60] could be phosphorylated by p38 alpha-beta in vitro , and forced activation of p38 alpha/beta in myoblasts by expression of a constitutively active ( refs. 5,6,7 ) *promoted* unscheduled SWI-SNF recruitment to the myogenin promoter . Positive_regulation ACVR1 IL1B 19116903 2025023 *reduced* the number of [activin receptor-like kinase 2 (ALK-2)] and ALK-3 receptors , inhibited expression of Smad1 and Smad6 , delayed and prematurely terminated the onset of OP-1 mediated R-Smad phosphorylation , and affected nuclear translocation of R-Smad/Smad4 complexes . Positive_regulation AD5 TNFSF10 16234248 1489436 [AD5-10] *induces* both caspase dependent and caspase independent cell death in Jurkat cells , whereas induces only caspase dependent cell death . Positive_regulation ADA IL1B 16860713 1588836 These drugs caused a marked reduction in MPO activity , as well as and TNFalpha levels ( P < 0.01 ) , but only Tacrolimus *inhibited* [ADA] activity ( P < 0.01 ) . Positive_regulation ADA NT5E 2541427 110492 Adenosine metabolism in hypothyrosis has been shown to decrease in thymocytes ( <5'-nucleotidase> activity decreases by 18 % and [adenosine deaminase] activity *increases* in thymocyte light fractions ) . Positive_regulation ADA NT5E 2842422 95382 Following an initial time lag of 24 h , mean [ADA] activity from seven separate experiments as measured in nmoles/10 ( 6 ) cells/h increased from a baseline of 31.3 +/- 9.3 to 57.8 +/- 16.4 ( P less than 0.005 ) at 72 h and to 72 +/- 21.5 ( P less than .025 ) by 96 h . <5NT> activity *increased* from a baseline of 2.2 +/- 0.9 to a maximum of 44 +/- 10.1 by 72 h and then declined to 29 +/- 18 ( P less than 0.005 ) by 96 h , while no significant change in PNP activity was observed . Positive_regulation ADA NT5E 9933023 589197 Erythro-9- ( 2-hydroxy-3-nonyl ) adenine ( 10 microM ) , an *inhibitor* of [ADA] , and alpha , beta-methyleneadenosine 5'-diphosphate ( 100 microM ) , an inhibitor of , did not alter forskolin activity . Positive_regulation ADA SELL 8781559 380385 This process might be dependent on a *mediated* increase in the expression and activity of [ADA] , which locally reduces the extracellular level of adenosine . Positive_regulation ADA TNF 16860713 1588835 These drugs caused a marked reduction in MPO activity , as well as IL-1beta and levels ( P < 0.01 ) , but only Tacrolimus *inhibited* [ADA] activity ( P < 0.01 ) . Positive_regulation ADAM10 EPHB2 22423111 2572943 We further showed that both the NMDAR- and Wnt3a induced [ADAM10] upregulation was *blocked* by inhibitors . Positive_regulation ADAM10 IL1B 22792188 2628268 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation ADAM10 MAP2K6 23674691 2791522 In contrast , inhibition *reduces* [ADAM-10] and -17 activities but fails to inhibit compensatory signaling from accumulated RTKs , which actually enhances cell motility in some contexts . Positive_regulation ADAM10 TNF 19213876 2127908 In contrast with the other HB-epidermal growth factor sheddases , [ADAM-10] and -17 , in vitro *increased* the expression of ADAM-12 by AEC , an effect amplified by IL-4 and IL-13 . Positive_regulation ADAM11 CCL17 11876749 918938 Our study strongly suggests that serum [MDC] levels have a notable correlation with disease activity and that MDC , as well as the , may be *involved* in the pathogenesis of AD . Positive_regulation ADAM11 IL1B 22792188 2628269 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation ADAM11 JAG1 20974985 2348716 Upregulation of OX40L and by mDC *resulted* in [mDC-driven] Th2 responses . Positive_regulation ADAM11 TLR7 17359388 1712638 [mDC] from atopic patients are not restricted in their *response* to . Positive_regulation ADAM11 TLR7 23794066 2824294 [mDC1] were surprisingly the only human DC that secreted high amounts of IL-12p70 , but they *required* combinational stimulation . Positive_regulation ADAM11 TNF 11352815 814886 In addition , *induced* [MDC/CCL22] secretion was differentially modulated by Th1 and Th2 cytokines . Positive_regulation ADAM11 TNF 11876523 918933 Chemokines are produced in a coordinated and sequential manner , with IL-8 and RANTES *induced* by during early stages , and MCP-1 , IP-10 , Mig , I-TAC , I-309 and [MDC] induced by IFN-gamma during later stages . Positive_regulation ADAM11 TNF 12670721 1076158 MDC mRNA was weakly expressed in HaCaT cells , and upon *stimulation* with or IFN-gamma , [MDC] expression was strongly upregulated . Positive_regulation ADAM11 TNF 16094077 1443615 Previously we have reported that RT4 , a well differentiated human bladder cancer line , increases the expression of [macrophage derived chemokine (MDC)] and interferon (IFN)-gamma-inducible protein-10 ( IP-10 ) in *response* to IFN-gamma and . Positive_regulation ADAM11 TNF 19371952 2081726 In the present study , we investigated the in vitro effects of the adenylyl cyclase-cAMP system on IFN-gamma and *stimulated* production of TARC and [MDC] in human HaCaT keratinocytes . Positive_regulation ADAM11 TNF 19371952 2081727 Moreover , inhibition of NF-kappaB suppressed TARC and [MDC] production *induced* by IFN-gamma plus . Positive_regulation ADAM11 TNF 22227193 2544611 Taken together , these results suggest that casuarinin may exert anti-inflammatory responses by suppressing *induced* expression of TARC and [MDC] via blockage of p38 MAPK activation and subsequent activation of NF-?B and STAT1 . Positive_regulation ADAM11 TNF 24704449 2935405 Furthermore , we showed that PKC? and p38 MAPK contributed to the inhibition of *induced* TARC/CCL17 and [MDC/CCL22] expression by blocking I?Ba degradation in HaCaT cells . Positive_regulation ADAM11 TNF 24704449 2935408 Taken together , these results suggest that ( + ) -nootkatone may suppress *induced* TARC/CCL17 and [MDC/CCL22] expression in HaCaT cells by inhibiting of PKC? and p38 MAPK signaling pathways that lead to activation of NF-?B . Positive_regulation ADAM12 IL1B 22792188 2628270 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation ADAM12 TNF 19213876 2127909 In contrast with the other HB-epidermal growth factor sheddases , ADAM-10 and -17 , in vitro *increased* the expression of [ADAM-12] by AEC , an effect amplified by IL-4 and IL-13 . Positive_regulation ADAM12 TNF 20176000 2228918 It appears that LPS- and *induced* [ADAM12] expression is mediated via the classic NFkappaB pathway . Positive_regulation ADAM15 IL1B 22792188 2628271 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation ADAM17 EPHB2 15923650 1414075 *mediated* phosphorylation of Thr735 in [TNFalpha converting enzyme] and its potential role in TACE protein trafficking . Positive_regulation ADAM17 EPHB2 20083499 2380903 For the first time , we show that , in fish macrophages , TNF-a is processed by [TACE-like] activity and this cleavage is *dependent* upon the activation of , p38MAPK and JNK signaling pathways by LPS . Positive_regulation ADAM17 EPHB2 20087163 2206040 [ADAM-17] is *activated* by the mitogenic protein kinase in a model of kidney fibrosis . Positive_regulation ADAM17 EPHB2 21949123 2502545 This is different from [ADAM17] stimulation upon overt neutrophil activation , which *requires* MAPK p38 or , but not caspases and reactive oxygen species . Positive_regulation ADAM17 HBEGF 24037740 2885396 In vitro , in these cells TWEAK phosphorylated EGFR via Fn14 binding , [ADAM17] *activation* and subsequent release of the EGFR ligands and TGFa . Positive_regulation ADAM17 IL1B 18021299 1866870 did not significantly alter the mRNA levels of BACE1 , ADAM-9 , and ADAM-10 , but *up-regulated* that of [TACE] by threefold . Positive_regulation ADAM17 IL1B 22792188 2628272 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation ADAM17 MAP2K6 23674691 2791529 In contrast , inhibition *reduces* [ADAM-10 and -17] activities but fails to inhibit compensatory signaling from accumulated RTKs , which actually enhances cell motility in some contexts . Positive_regulation ADAM17 MMP28 15992779 1429597 This proves the principle that early neutrophil *inhibition* followed by [TACE] blockade may become a treatment strategy of gram negative sepsis , endotoxinemia and other life threatening inflammatory reactions . Positive_regulation ADAM17 MMP7 15992779 1429612 This proves the principle that early neutrophil *inhibition* followed by [TACE] blockade may become a treatment strategy of gram negative sepsis , endotoxinemia and other life threatening inflammatory reactions . Positive_regulation ADAM17 TNF 12441351 1037229 converting [enzyme/ADAM 17] *mediates* MUC1 shedding . Positive_regulation ADAM17 TNF 12646554 1091985 Histamine induced shedding is blocked by protease inhibitor , an *inhibitor* of [TNF-alpha converting enzyme] , and through the H1 receptor via a MEK-1/p42 and p44 mitogen activated protein kinase pathway . Positive_regulation ADAM17 TNF 16982746 1617152 The proteolytic activity of [ADAM17/TACE] , assessed by the release of TNF-alpha , was *inhibited* by protease inhibitor . Positive_regulation ADAM17 TNF 18364436 1912760 We , for the first time , demonstrate that binding of staphylococcal enterotoxin B to MHC-II results in activation of [TNF-alpha converting enzyme] , epidermal growth factor receptor , p38MAPK , and NF-kappaB *inducing* biphasic production . Positive_regulation ADAM17 TNF 18490652 1921792 Modulation of [TNF-alpha converting enzyme] by the spike protein of SARS-CoV and ACE2 *induces* production and facilitates viral entry . Positive_regulation ADAM17 TNF 19213876 2127910 In contrast with the other HB-epidermal growth factor sheddases , [ADAM-10 and -17] , in vitro *increased* the expression of ADAM-12 by AEC , an effect amplified by IL-4 and IL-13 . Positive_regulation ADAM17 TNF 19299578 2080084 *induced* an early upregulation of [ADAM17] in T84 cells , whereas PMNL adhesion , H ( 2 ) O ( 2 ) , or epithelial tight junction opening alone did not affect the amount of ADAM17 . Positive_regulation ADAM17 TNF 22246777 2538278 signaling *requires* iRhom2 to promote trafficking and activation of [TACE] . Positive_regulation ADAM17 TNF 23703665 2843763 In WT mice on the CDAA or WD , Sirt1 and Timp3 expressions were lower , whereas production of reactive oxidative species and [TACE] activity significantly *increased* with an increase in active production as well as induction of fibrogenic transcripts . Positive_regulation ADAM18 IL1B 22792188 2628273 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation ADAM19 IL1B 22792188 2628274 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation ADAM19 TNF 23429442 2744326 [ADAM19] expression was *increased* in colonic epithelial cell lines and normal colonic explants by , interleukin 21 and interleukin 6 , and was downregulated in IBD tissue by infliximab . Positive_regulation ADAM2 IL1B 22792188 2628275 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation ADAM20 IL1B 22792188 2628276 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation ADAM21 IL1B 22792188 2628277 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation ADAM22 IL1B 22792188 2628278 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation ADAM23 IL1B 22792188 2628279 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation ADAM28 IL1B 22792188 2628280 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation ADAM28 MMP7 15013428 1220654 [ADAM28] is *activated* by ( matrilysin-1 ) and cleaves insulin-like growth factor binding protein-3 . Positive_regulation ADAM29 IL1B 22792188 2628281 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation ADAM30 IL1B 22792188 2628282 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation ADAM32 IL1B 22792188 2628267 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation ADAM33 IL1B 22792188 2628266 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation ADAM5 IL1B 22792188 2628283 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation ADAM6 IL1B 22792188 2628284 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation ADAM7 IL1B 22792188 2628285 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation ADAM8 IL1B 22792188 2628286 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation ADAM8 TNF 11050116 743328 In primary astrocytes from wild-type and WR mice , in primary cerebellar neurons , and in mouse motoneuron-like NSC19 cells , [ADAM8] expression was *induced* up to 15-fold by mouse , in a dose dependent manner . Positive_regulation ADAM8 TNF 11050116 743329 In both cell types , [ADAM8] was also *induced* by human , indicating that TNF receptor type I ( p55 ) is involved . Positive_regulation ADAM8 TNF 11050116 743330 We conclude that IRF-1 mediated *induction* of [ADAM8] by is a signaling pathway relevant for neurodegenerative disorders with glia activation , proposing a role for ADAM8 in cell adhesion during neurodegeneration . Positive_regulation ADAM8 TNF 20826683 2318785 In motor neuron ( MN ) disease of the mouse , exemplified by the model wobbler ( WR ) , *causes* upregulation of the metalloprotease-disintegrin [ADAM8 (A8)] in affected brain regions , spinal cord , and brainstem . Positive_regulation ADAM9 IL1B 22792188 2628287 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation ADAMTS1 BGLAP 15777654 1390002 Of these , [ADAMTS-1] *followed* most closely the osteogenic marker during in vitro mineralisation . Positive_regulation ADAMTS1 ERG 19396168 2070252 [ADAMTS1] and CXCR4 , two candidate genes strongly associated with cell migration , were upregulated in the *presence* of overexpression . Positive_regulation ADAMTS1 GRAP2 20619343 2327825 Pharmacological inhibitors of ( SB203580 ) or p38-a/ß/?/d ( BIRB-0796 ) *reduced* MMP-3 and [ADAMTS1] mRNA expression , but neither inhibitor affected MMP-9 levels . Positive_regulation ADAMTS1 IL17A 23977238 2832976 Moreover , in cultured cardiac fibroblasts , *induced* the expression of [ADAMTS-1] , MMP-2 , and collagen subtypes I and III and increased the proliferation of fibroblasts . Positive_regulation ADAMTS1 IL1A 11311987 805187 These findings suggest that nerve injury promotes IL-1RT1 expression in the injured neurons and thereby [ADAMTS-1] transcription was induced in *response* to released from glial cells . Positive_regulation ADAMTS1 IL1B 15880812 1406220 *increased* messenger RNA ( mRNA ) levels of ADAMTS4 , ADAMTS5 , and ADAMTS9 but not [ADAMTS1] and ADAMTS8 . Positive_regulation ADAMTS1 IL1B 16675485 1589774 and TGF-beta1 differentially *regulate* [ADAMTS-1] expression in human decidual stromal cells . Positive_regulation ADAMTS1 IL1B 16949904 1673227 [ADAMTS1] is *regulated* by , not by hypoxia , in chondrosarcoma . Positive_regulation ADAMTS1 IL1R1 11311987 805188 These findings suggest that nerve injury promotes expression in the injured neurons and thereby [ADAMTS-1] transcription was *induced* in response to IL-1 released from glial cells . Positive_regulation ADAMTS1 LEP 15629898 1362330 Rather , *induced* hyperemia and leakage in the follicle , as well as the proteinase [ADAMTS-1] ( a disintegrin and metalloproteinase with a thrombospondin-like motif ) , which facilitates extrusion of the follicular content . Positive_regulation ADAMTS1 OSM 15883123 1464969 In human chondrocytes , also *enhanced* [ADAMTS-1] and -4 expression , but not that of other ADAMTSs . Positive_regulation ADAMTS1 PGF 20840749 2325650 Using FPS cells , we show that signalling *upregulates* [ADAMTS1] expression via a calmodulin-NFAT dependent pathway and this promotes epithelial cell invasion through ECM and inhibits endothelial cell proliferation . Positive_regulation ADAMTS1 PIK3CA 19349275 2088726 The inhibitor LY294002 dose-dependently *inhibited* the increase of [ADAMTS1] mRNA expression in hypoxia . Positive_regulation ADAMTS1 PIK3R1 19349275 2088727 The inhibitor LY294002 dose-dependently *inhibited* the increase of [ADAMTS1] mRNA expression in hypoxia . Positive_regulation ADAMTS1 PTH 11108265 756813 We also analyzed the regulation of ADAMTS-1 in response to various PTH/PTH related peptide (PTHrP) analogs and found that ( 1-31 ) and PTHrP- ( 1-34 ) , which activate the protein kinase A (PKA) pathway , *induce* [ADAMTS-1] expression 1 h after injection , whereas PTH- ( 3-34 ) and PTH- ( 7-34 ) , which do not activate the PKA pathway , did not regulate expression . Positive_regulation ADAMTS1 PTH 17560840 1767657 The multi-domain neutral endopeptidase , [ADAMTS-1] ( a disintegrin and metalloprotease with thrombospondin repeats ) is *induced* by in rat osteoblasts and has therefore been suggested to be involved in initiation of bone remodeling . Positive_regulation ADAMTS1 PTH 17560840 1767659 Here , we first establish that [ADAMTS-1] protein is rapidly and transiently produced by human primary osteoblasts in *response* to ( 1-34 ) . Positive_regulation ADAMTS1 PTHLH 11108265 756814 We also analyzed the regulation of ADAMTS-1 in response to various PTH/PTH related peptide (PTHrP) analogs and found that PTH- ( 1-31 ) and ( 1-34 ) , which activate the protein kinase A (PKA) pathway , *induce* [ADAMTS-1] expression 1 h after injection , whereas PTH- ( 3-34 ) and PTH- ( 7-34 ) , which do not activate the PKA pathway , did not regulate expression . Positive_regulation ADAMTS1 RENBP 21482542 2448359 *enhanced* expression and enzyme activity of MMP and [ADAMTS] genes and resulted in reduction of collagen II . Positive_regulation ADAMTS1 RENBP 21482542 2448416 Blocking JAK/STAT3 signalling pathway inhibited *induced* activation of MMP-13 and [ADAMTS] and prevented AGE mediated decrease of collagen II and proteoglycan ( aggrecan ) . Positive_regulation ADAMTS1 S100A6 15256533 1295944 *Activation* of the [ADAMTS-1] promoter by involves functional CAAT enhancer binding protein beta , nuclear factor 1-like factor , and three Sp1/Sp3 binding sites as demonstrated by transfection of mutated promoter constructs . Positive_regulation ADAMTS1 SETD2 19349275 2088728 In summary , we found that [ADAMTS1] is transiently induced by hypoxia in endothelial cells , and its transcription is *mediated* by binding . Positive_regulation ADAMTS1 TGFB1 16675485 1589773 IL-1beta and differentially *regulate* [ADAMTS-1] expression in human decidual stromal cells . Positive_regulation ADAMTS1 TNF 12697333 1081329 The expression of [ADAMTS] genes in ARPE-19 cells and the transcriptional *stimulation* of some family members by may implicate them in inflammatory eye disease and the compromise of retinal matrix structure , which is evident in age related macular degeneration ( ARMD ) and other retinal pathologies . Positive_regulation ADAMTS1 TNF 14996435 1216239 High-density lipoprotein subfraction 3 decreases [ADAMTS-1] expression *induced* by lipopolysaccharide and in human endothelial cells . Positive_regulation ADAMTS1 TNF 15883123 1464968 In human chondrocytes , also *enhanced* [ADAMTS-1] and -4 expression , but not that of other ADAMTSs . Positive_regulation ADAMTS1 VEGFA 16936124 1608929 *upregulates* expression of [ADAMTS1] in endothelial cells through protein kinase C signaling . Positive_regulation ADAMTS1 VEGFA 16936124 1608932 These results indicate that significantly *induces* [ADAMTS1] expression in endothelial cells in a PKC dependent fashion . Positive_regulation ADAMTS1 VEGFA 18272597 1891230 Renal ischemia reperfusion inhibits expression and *induces* [ADAMTS-1] , a novel VEGF inhibitor . Positive_regulation ADAMTS10 TNF 12697333 1081318 The expression of [ADAMTS] genes in ARPE-19 cells and the transcriptional *stimulation* of some family members by may implicate them in inflammatory eye disease and the compromise of retinal matrix structure , which is evident in age related macular degeneration ( ARMD ) and other retinal pathologies . Positive_regulation ADAMTS12 TNF 12697333 1081321 The expression of [ADAMTS] genes in ARPE-19 cells and the transcriptional *stimulation* of some family members by may implicate them in inflammatory eye disease and the compromise of retinal matrix structure , which is evident in age related macular degeneration ( ARMD ) and other retinal pathologies . Positive_regulation ADAMTS12 TNF 20506400 2283904 The role of GEP in inhibiting *induced* [ADAMTS-7/ADAMTS-12] expression and COMP degradation in cartilage explants was also analyzed . Positive_regulation ADAMTS12 TNF 20506400 2283910 More importantly , GEP inhibited COMP degradation by ADAMTS-7/ADAMTS-12 in a dose dependent manner through 1 ) competitive inhibition through direct protein-protein interactions with ADAMTS-7/ADAMTS-12 and COMP , and 2 ) inhibition of *induced* [ADAMTS-7/ADAMTS-12] expression . Positive_regulation ADAMTS13 TNF 12697333 1081320 The expression of [ADAMTS] genes in ARPE-19 cells and the transcriptional *stimulation* of some family members by may implicate them in inflammatory eye disease and the compromise of retinal matrix structure , which is evident in age related macular degeneration ( ARMD ) and other retinal pathologies . Positive_regulation ADAMTS13 TNF 23816135 2824693 IL-6 decreased ADAMTS13 expression , and *had* no significant effects on [ADAMTS13] expression in podocytes . Positive_regulation ADAMTS14 TNF 12697333 1081322 The expression of [ADAMTS] genes in ARPE-19 cells and the transcriptional *stimulation* of some family members by may implicate them in inflammatory eye disease and the compromise of retinal matrix structure , which is evident in age related macular degeneration ( ARMD ) and other retinal pathologies . Positive_regulation ADAMTS15 TNF 12697333 1081323 The expression of [ADAMTS] genes in ARPE-19 cells and the transcriptional *stimulation* of some family members by may implicate them in inflammatory eye disease and the compromise of retinal matrix structure , which is evident in age related macular degeneration ( ARMD ) and other retinal pathologies . Positive_regulation ADAMTS16 TNF 12697333 1081324 The expression of [ADAMTS] genes in ARPE-19 cells and the transcriptional *stimulation* of some family members by may implicate them in inflammatory eye disease and the compromise of retinal matrix structure , which is evident in age related macular degeneration ( ARMD ) and other retinal pathologies . Positive_regulation ADAMTS17 TNF 12697333 1081325 The expression of [ADAMTS] genes in ARPE-19 cells and the transcriptional *stimulation* of some family members by may implicate them in inflammatory eye disease and the compromise of retinal matrix structure , which is evident in age related macular degeneration ( ARMD ) and other retinal pathologies . Positive_regulation ADAMTS18 TNF 12697333 1081326 The expression of [ADAMTS] genes in ARPE-19 cells and the transcriptional *stimulation* of some family members by may implicate them in inflammatory eye disease and the compromise of retinal matrix structure , which is evident in age related macular degeneration ( ARMD ) and other retinal pathologies . Positive_regulation ADAMTS19 TNF 12697333 1081327 The expression of [ADAMTS] genes in ARPE-19 cells and the transcriptional *stimulation* of some family members by may implicate them in inflammatory eye disease and the compromise of retinal matrix structure , which is evident in age related macular degeneration ( ARMD ) and other retinal pathologies . Positive_regulation ADAMTS2 TNF 12697333 1081330 The expression of [ADAMTS] genes in ARPE-19 cells and the transcriptional *stimulation* of some family members by may implicate them in inflammatory eye disease and the compromise of retinal matrix structure , which is evident in age related macular degeneration ( ARMD ) and other retinal pathologies . Positive_regulation ADAMTS20 TNF 12697333 1081328 The expression of [ADAMTS] genes in ARPE-19 cells and the transcriptional *stimulation* of some family members by may implicate them in inflammatory eye disease and the compromise of retinal matrix structure , which is evident in age related macular degeneration ( ARMD ) and other retinal pathologies . Positive_regulation ADAMTS3 TNF 12697333 1081331 The expression of [ADAMTS] genes in ARPE-19 cells and the transcriptional *stimulation* of some family members by may implicate them in inflammatory eye disease and the compromise of retinal matrix structure , which is evident in age related macular degeneration ( ARMD ) and other retinal pathologies . Positive_regulation ADAMTS4 EPHB2 14709335 1196634 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced MMP and [ADAM-TS4] gene expression . Positive_regulation ADAMTS4 IL1B 15880812 1406221 *increased* messenger RNA ( mRNA ) levels of [ADAMTS4] , ADAMTS5 , and ADAMTS9 but not ADAMTS1 and ADAMTS8 . Positive_regulation ADAMTS4 IL1B 16206353 1464177 Pretreatment with 0.5 microM Se-met prevented *induced* MMP-1 and [aggrecanase-1] expression , and reduced the cytokine inhibitory effect on type II collagen , aggrecan core protein , and TGF-beta receptor II ( TGF-betaRII ) mRNA levels . Positive_regulation ADAMTS4 IL1B 17888210 1797461 *induced* stimulation of the MMPs and [aggrecanase-1] was markedly inhibited by rhein . Positive_regulation ADAMTS4 IL1B 17901089 1888862 No effect of CS was observed on *induced* gelatinolytic activity , MMP1 mRNA expression or [ADAMTS-4] expression . Positive_regulation ADAMTS4 IL1B 18565769 1984268 In the *presence* of , FGF-18 increased expression of [ADAMTS-4] , aggrecan , BMP-2 , COL2A1 , CCL3 , CCL4 , CCL20 , CXCL1 , CXCL3 , CXCL6 , IL-1beta , IL-6 , and IL-8 and decreased ADAMTS-5 , MMP-13 , CCL2 , and CCL8 . Positive_regulation ADAMTS4 IL1B 19342688 2056857 By small interfering RNAs mediated knockdown , we show that *induced* up-regulation of [ADAMTS-4] in chondrocytes requires MyD88 , IRAK1 , and TRAF6 adaptor proteins . Positive_regulation ADAMTS4 IL1B 19342688 2056881 These findings suggest that Ras , ROS along with MyD88 , IRAK1 , or TRAF6 synergistically *mediate* [ADAMTS-4] regulation by . Positive_regulation ADAMTS4 IL1B 21856929 2496233 The PRPr also reduced *induced* increase of [ADAMTS4] and PTGS2 gene expression . Positive_regulation ADAMTS4 TNF 12697333 1081332 The expression of [ADAMTS] genes in ARPE-19 cells and the transcriptional *stimulation* of some family members by may implicate them in inflammatory eye disease and the compromise of retinal matrix structure , which is evident in age related macular degeneration ( ARMD ) and other retinal pathologies . Positive_regulation ADAMTS4 TNF 15629465 1362290 TWHF extract and PG490 also suppressed IL-1- , IL-17- , and *induced* expression of [ADAMTS-4] in bovine chondrocytes . Positive_regulation ADAMTS4 TNF 15883123 1464970 In human chondrocytes , also *enhanced* [ADAMTS-1 and -4] expression , but not that of other ADAMTSs . Positive_regulation ADAMTS4 TNF 17606262 1858004 Macrophage expression of [ADAMTS-4] , -7 , -8 and -9 mRNA were enhanced upon *stimulation* with IFN-gamma or . Positive_regulation ADAMTS4 TNF 19342682 2056815 However , CD36 transfection in normal human knee immortalized chondrocytes ( CH-8 cells ) was associated with decreased capacity of S100A11 and to *induce* chondrocyte hypertrophy and [ADAMTS-4] and matrix metalloproteinase 13 expression . Positive_regulation ADAMTS4 TNF 23602832 2789787 Lentiviral transduction with shRNA plasmids shp65 , shp52 , shIKK-a , and shIKK-ß significantly decreased *dependent* increase in [ADAMTS-4] and -5 levels and aggrecan degradation . Positive_regulation ADAMTS4 TNF 24126638 2858874 *induces* [ADAMTS-4] expression in human osteoarthritis chondrocytes . Positive_regulation ADAMTS4 TNF 24126638 2858876 *increased* the [ADAMTS-4] mRNA level in a statistically significant dose- and time dependent manner within 18 h , which was reflected in the dose dependent induction of the ADAMTS-4 promoter activity , ADAMTS-4 protein expression and ADAMTS-4 activity . Positive_regulation ADAMTS4 TNF 24126638 2858879 *induces* [ADAMTS-4] expression and activity in human osteoarthritic chondrocytes at the transcriptional level via TNFR1 by a p38 MAPK dependent mechanism . Positive_regulation ADAMTS5 IL1B 15880812 1406222 *increased* messenger RNA ( mRNA ) levels of ADAMTS4 , [ADAMTS5] , and ADAMTS9 but not ADAMTS1 and ADAMTS8 . Positive_regulation ADAMTS5 IL1B 19714579 2139313 Transfection of chondrocytes with ds-miR-140 down-regulated *induced* [ADAMTS5] expression and rescued the IL-1beta dependent repression of AGGRECAN gene expression . Positive_regulation ADAMTS5 IL1B 19763723 2247721 In vitro , muscone reversed *induced* upregulation of IL-1beta , tumor necrosis factor alpha , cyclooxygenase 2 , inducible nitric oxide synthase , matrix metalloproteinase 13 , [aggrecanase 2] , and nitric oxide and downregulation of Col2alpha1 and aggrecan . Positive_regulation ADAMTS5 TNF 12697333 1081333 The expression of [ADAMTS] genes in ARPE-19 cells and the transcriptional *stimulation* of some family members by may implicate them in inflammatory eye disease and the compromise of retinal matrix structure , which is evident in age related macular degeneration ( ARMD ) and other retinal pathologies . Positive_regulation ADAMTS5 TNF 23602832 2789788 Lentiviral transduction with shRNA plasmids shp65 , shp52 , shIKK-a , and shIKK-ß significantly decreased *dependent* increase in [ADAMTS-4 and -5] levels and aggrecan degradation . Positive_regulation ADAMTS6 TNF 12697333 1081334 The expression of [ADAMTS] genes in ARPE-19 cells and the transcriptional *stimulation* of some family members by may implicate them in inflammatory eye disease and the compromise of retinal matrix structure , which is evident in age related macular degeneration ( ARMD ) and other retinal pathologies . Positive_regulation ADAMTS7 TNF 12697333 1081335 The expression of [ADAMTS] genes in ARPE-19 cells and the transcriptional *stimulation* of some family members by may implicate them in inflammatory eye disease and the compromise of retinal matrix structure , which is evident in age related macular degeneration ( ARMD ) and other retinal pathologies . Positive_regulation ADAMTS7 TNF 20506400 2283906 The role of GEP in inhibiting *induced* [ADAMTS-7/ADAMTS-12] expression and COMP degradation in cartilage explants was also analyzed . Positive_regulation ADAMTS7 TNF 20506400 2283911 More importantly , GEP inhibited COMP degradation by ADAMTS-7/ADAMTS-12 in a dose dependent manner through 1 ) competitive inhibition through direct protein-protein interactions with ADAMTS-7/ADAMTS-12 and COMP , and 2 ) inhibition of *induced* [ADAMTS-7/ADAMTS-12] expression . Positive_regulation ADAMTS7 TNF 23928557 2942225 in addition , *induced* [ADAMTS-7] through NF-?B signalling . Positive_regulation ADAMTS8 TNF 12697333 1081336 The expression of [ADAMTS] genes in ARPE-19 cells and the transcriptional *stimulation* of some family members by may implicate them in inflammatory eye disease and the compromise of retinal matrix structure , which is evident in age related macular degeneration ( ARMD ) and other retinal pathologies . Positive_regulation ADAMTS9 IL1B 15880812 1406218 [ADAMTS-9] is synergistically *induced* by and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes . Positive_regulation ADAMTS9 IL1B 15880812 1406219 *increased* messenger RNA ( mRNA ) levels of ADAMTS4 , ADAMTS5 , and [ADAMTS9] but not ADAMTS1 and ADAMTS8 . Positive_regulation ADAMTS9 IL1B 19052845 2029718 [ADAMTS9] *activation* by via NFATc1 in OUMS-27 chondrosarcoma cells and in human chondrocytes . Positive_regulation ADAMTS9 TNF 12697333 1081319 The expression of [ADAMTS] genes in ARPE-19 cells and the transcriptional *stimulation* of some family members by may implicate them in inflammatory eye disease and the compromise of retinal matrix structure , which is evident in age related macular degeneration ( ARMD ) and other retinal pathologies . Positive_regulation ADAMTS9 TNF 15883123 1464973 alone *induced* [ADAMTS-9] expression , whereas OSM addition caused suppression . Positive_regulation ADAMTS9 TNF 15883123 1464974 Both TGFbeta1 and IL4 blocked membrane associated aggrecanase activity and decreased *induced* expression of [ADAMTS-9] in bovine and human chondrocytes . Positive_regulation ADC IL1B 11050138 743342 The presence of neutrophils within the brain parenchyma significantly contributed to the *induced* changes in cerebral blood volume and the [ADC] of brain water . Positive_regulation ADCY1 ADRB2 10950942 723568 A *activates* [adenylate cyclase] in human erythrocyte membranes at physiological calcium plasma concentrations . Positive_regulation ADCY1 ADRB2 1326677 197561 The effects of prostaglandin E2 ( PGE2 ) infusions on lymphocyte *dependent* [adenylate cyclase] ( beta 2ARAC ) system were studied in 26 patients with resistant hypertension ( RH ) . Positive_regulation ADCY1 ADRB2 3034291 73352 Characterization of the *dependent* [adenylate cyclase] of A431 epidermoid carcinoma cells . Positive_regulation ADCY1 ADRB2 7809956 284941 [ The effect of sodium and ouabain on the activation of *dependent* [adenylate cyclase] in human lymphocytes ] . Positive_regulation ADCY1 CDKN1C 11880488 919422 Pituitary [adenylate cyclase] activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is *regulated* by dependent CDK2 activity . Positive_regulation ADCY1 EDN2 10750028 681331 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone , indicating that [adenylate cyclase] and TNFalpha *induce* synthesis by separate signalling pathways . Positive_regulation ADCY1 EDN2 1319997 190044 , added together with GTP , *activated* the [adenylate cyclase] activity in membrane preparations of ETA expressing cells , indicating the direct linkage of ETA to the adenylate cyclase system . Positive_regulation ADCY1 EPHB2 16973907 1628034 Indeed , we observed similar isoform dependent association of AC1 with ERK , *activation* of by stimulation of [AC1] with forskolin , and AC1 dependent lengthening of doubling time , indicating that these properties of AC1 are cell autologous and likely result from AC1 dependent protein-protein interactions . Positive_regulation ADCY1 EPHB2 23800469 2802944 With loss-of-function experiments in the rat neuronal cell line Neuroscreen-1 (NS-1) and gain-of-function experiments in human embryonic kidney 293T cells , we demonstrated that Rapgef2 connected GPCR dependent activation of [adenylate cyclase] and *increased* cAMP concentration with the activation of in neurons and endocrine cells . Positive_regulation ADCY1 GPR115 9753683 534282 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY1 GPR132 9753683 534271 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY1 GPR87 9753683 534351 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY1 IL1B 7506523 239954 Calcitonin (CT) , substance P ( SP ) , , and transforming growth factor-beta 1 ( TGF beta 1 ) *had* no effect on [adenylate cyclase] in either fibroblast . Positive_regulation ADCY1 MAP2K6 17877640 1796462 In one clone ( PC47 ) , ICP10PK inhibited caspase-3 activation through up-regulation/stabilization of [adenylate cyclase (AC)] , *activation* of PKA and , and the convergence of the two pathways on extracellular signal regulated kinase activation . Positive_regulation ADCY1 PTGER2 15947091 1452189 The effect of PGE2 is mediated by *activation* of [adenylate cyclase] via the Gs-protein coupled receptor . Positive_regulation ADCY1 SELL 1521577 197000 Addition of the octapeptide , Met5-enk *resulted* in decreased [adenylate cyclase] activity ; Positive_regulation ADCY1 SRGN 3514598 57794 This method was used to investigate the relationship between the rate of *activation* of [adenylate cyclase] by p ( NH ) and GTP gamma S and their apparent affinities . Positive_regulation ADCY1 SRGN 4039563 48576 p [ NH ] *stimulated* [adenylate cyclase] activity was reconstituted by mixing samples from the gel-filtration column containing Gs with C unit . Positive_regulation ADCY1 SRGN 6249258 11519 3. Trypsin treatment of intact hepatocytes has no effect on the basal , fluoride- , GTP- or p [ NH ] *stimulated* [adenylate cyclase] activity . Positive_regulation ADCY1 SRGN 6298116 25185 In contrast , the GTP analogue p ( NH ) ( guanosine 5'beta , gamma-imido triphosphate ) *caused* a persistent activation of the [adenylate cyclase] . Positive_regulation ADCY1 SRGN 6615475 30624 The lag observed in the p [ NH ] *stimulated* [adenylate cyclase] activity of native membranes was abolished when membranes from glucagon pretreated cells were used . Positive_regulation ADCY10 ADRB2 10950942 723567 A *activates* [adenylate cyclase] in human erythrocyte membranes at physiological calcium plasma concentrations . Positive_regulation ADCY10 ADRB2 1326677 197560 The effects of prostaglandin E2 ( PGE2 ) infusions on lymphocyte *dependent* [adenylate cyclase] ( beta 2ARAC ) system were studied in 26 patients with resistant hypertension ( RH ) . Positive_regulation ADCY10 ADRB2 3034291 73351 Characterization of the *dependent* [adenylate cyclase] of A431 epidermoid carcinoma cells . Positive_regulation ADCY10 ADRB2 7809956 284940 [ The effect of sodium and ouabain on the activation of *dependent* [adenylate cyclase] in human lymphocytes ] . Positive_regulation ADCY10 CA12 3136415 95879 Ultrastructural localization of and its possible *role* in the endolymphatic [sac] . Positive_regulation ADCY10 CDKN1C 11880488 919420 Pituitary [adenylate cyclase] activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is *regulated* by dependent CDK2 activity . Positive_regulation ADCY10 EDN2 10750028 681330 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone , indicating that [adenylate cyclase] and TNFalpha *induce* synthesis by separate signalling pathways . Positive_regulation ADCY10 EDN2 1319997 190041 , added together with GTP , *activated* the [adenylate cyclase] activity in membrane preparations of ETA expressing cells , indicating the direct linkage of ETA to the adenylate cyclase system . Positive_regulation ADCY10 EPHB2 23800469 2802943 With loss-of-function experiments in the rat neuronal cell line Neuroscreen-1 (NS-1) and gain-of-function experiments in human embryonic kidney 293T cells , we demonstrated that Rapgef2 connected GPCR dependent activation of [adenylate cyclase] and *increased* cAMP concentration with the activation of in neurons and endocrine cells . Positive_regulation ADCY10 GPR115 9753683 534188 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY10 GPR132 9753683 534177 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY10 GPR87 9753683 534257 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY10 IL1B 7506523 239952 Calcitonin (CT) , substance P ( SP ) , , and transforming growth factor-beta 1 ( TGF beta 1 ) *had* no effect on [adenylate cyclase] in either fibroblast . Positive_regulation ADCY10 MAP2K6 17877640 1796449 In one clone ( PC47 ) , ICP10PK inhibited caspase-3 activation through up-regulation/stabilization of [adenylate cyclase (AC)] , *activation* of PKA and , and the convergence of the two pathways on extracellular signal regulated kinase activation . Positive_regulation ADCY10 PTGER2 15947091 1452188 The effect of PGE2 is mediated by *activation* of [adenylate cyclase] via the Gs-protein coupled receptor . Positive_regulation ADCY10 SELL 1521577 196997 Addition of the octapeptide , Met5-enk *resulted* in decreased [adenylate cyclase] activity ; Positive_regulation ADCY10 SRGN 3514598 57793 This method was used to investigate the relationship between the rate of *activation* of [adenylate cyclase] by p ( NH ) and GTP gamma S and their apparent affinities . Positive_regulation ADCY10 SRGN 4039563 48575 p [ NH ] *stimulated* [adenylate cyclase] activity was reconstituted by mixing samples from the gel-filtration column containing Gs with C unit . Positive_regulation ADCY10 SRGN 6249258 11518 3. Trypsin treatment of intact hepatocytes has no effect on the basal , fluoride- , GTP- or p [ NH ] *stimulated* [adenylate cyclase] activity . Positive_regulation ADCY10 SRGN 6298116 25184 In contrast , the GTP analogue p ( NH ) ( guanosine 5'beta , gamma-imido triphosphate ) *caused* a persistent activation of the [adenylate cyclase] . Positive_regulation ADCY10 SRGN 6615475 30623 The lag observed in the p [ NH ] *stimulated* [adenylate cyclase] activity of native membranes was abolished when membranes from glucagon pretreated cells were used . Positive_regulation ADCY2 ADRB2 10950942 723569 A *activates* [adenylate cyclase] in human erythrocyte membranes at physiological calcium plasma concentrations . Positive_regulation ADCY2 ADRB2 1326677 197562 The effects of prostaglandin E2 ( PGE2 ) infusions on lymphocyte *dependent* [adenylate cyclase] ( beta 2ARAC ) system were studied in 26 patients with resistant hypertension ( RH ) . Positive_regulation ADCY2 ADRB2 3034291 73353 Characterization of the *dependent* [adenylate cyclase] of A431 epidermoid carcinoma cells . Positive_regulation ADCY2 ADRB2 7809956 284942 [ The effect of sodium and ouabain on the activation of *dependent* [adenylate cyclase] in human lymphocytes ] . Positive_regulation ADCY2 ADRB2 9349525 460764 Using a human cell line , ODM-2 , derived from the nonpigmented ciliary epithelium , we demonstrate that ( 1 ) NT expression is highly activated by nerve growth factor , glucocorticoid , and activators of [adenylate cyclase; (2)] NTr expression is *up-regulated* by selective ligand activated ; Positive_regulation ADCY2 CDKN1C 11880488 919424 Pituitary [adenylate cyclase] activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is *regulated* by dependent CDK2 activity . Positive_regulation ADCY2 EDN2 10750028 681332 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone , indicating that [adenylate cyclase] and TNFalpha *induce* synthesis by separate signalling pathways . Positive_regulation ADCY2 EDN2 1319997 190047 , added together with GTP , *activated* the [adenylate cyclase] activity in membrane preparations of ETA expressing cells , indicating the direct linkage of ETA to the adenylate cyclase system . Positive_regulation ADCY2 EPHB2 23800469 2802945 With loss-of-function experiments in the rat neuronal cell line Neuroscreen-1 (NS-1) and gain-of-function experiments in human embryonic kidney 293T cells , we demonstrated that Rapgef2 connected GPCR dependent activation of [adenylate cyclase] and *increased* cAMP concentration with the activation of in neurons and endocrine cells . Positive_regulation ADCY2 GPR115 9753683 534376 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY2 GPR132 9753683 534365 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY2 GPR87 9753683 534445 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY2 IL1B 7506523 239956 Calcitonin (CT) , substance P ( SP ) , , and transforming growth factor-beta 1 ( TGF beta 1 ) *had* no effect on [adenylate cyclase] in either fibroblast . Positive_regulation ADCY2 MAP2K6 17877640 1796475 In one clone ( PC47 ) , ICP10PK inhibited caspase-3 activation through up-regulation/stabilization of [adenylate cyclase (AC)] , *activation* of PKA and , and the convergence of the two pathways on extracellular signal regulated kinase activation . Positive_regulation ADCY2 PTGER2 15947091 1452190 The effect of PGE2 is mediated by *activation* of [adenylate cyclase] via the Gs-protein coupled receptor . Positive_regulation ADCY2 SELL 1521577 197003 Addition of the octapeptide , Met5-enk *resulted* in decreased [adenylate cyclase] activity ; Positive_regulation ADCY2 SRGN 3514598 57795 This method was used to investigate the relationship between the rate of *activation* of [adenylate cyclase] by p ( NH ) and GTP gamma S and their apparent affinities . Positive_regulation ADCY2 SRGN 4039563 48577 p [ NH ] *stimulated* [adenylate cyclase] activity was reconstituted by mixing samples from the gel-filtration column containing Gs with C unit . Positive_regulation ADCY2 SRGN 6249258 11520 3. Trypsin treatment of intact hepatocytes has no effect on the basal , fluoride- , GTP- or p [ NH ] *stimulated* [adenylate cyclase] activity . Positive_regulation ADCY2 SRGN 6298116 25186 In contrast , the GTP analogue p ( NH ) ( guanosine 5'beta , gamma-imido triphosphate ) *caused* a persistent activation of the [adenylate cyclase] . Positive_regulation ADCY2 SRGN 6615475 30625 The lag observed in the p [ NH ] *stimulated* [adenylate cyclase] activity of native membranes was abolished when membranes from glucagon pretreated cells were used . Positive_regulation ADCY3 ADRB2 10950942 723570 A *activates* [adenylate cyclase] in human erythrocyte membranes at physiological calcium plasma concentrations . Positive_regulation ADCY3 ADRB2 1326677 197563 The effects of prostaglandin E2 ( PGE2 ) infusions on lymphocyte *dependent* [adenylate cyclase] ( beta 2ARAC ) system were studied in 26 patients with resistant hypertension ( RH ) . Positive_regulation ADCY3 ADRB2 3034291 73354 Characterization of the *dependent* [adenylate cyclase] of A431 epidermoid carcinoma cells . Positive_regulation ADCY3 ADRB2 7809956 284943 [ The effect of sodium and ouabain on the activation of *dependent* [adenylate cyclase] in human lymphocytes ] . Positive_regulation ADCY3 CDKN1C 11880488 919426 Pituitary [adenylate cyclase] activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is *regulated* by dependent CDK2 activity . Positive_regulation ADCY3 EDN2 10750028 681333 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone , indicating that [adenylate cyclase] and TNFalpha *induce* synthesis by separate signalling pathways . Positive_regulation ADCY3 EDN2 1319997 190050 , added together with GTP , *activated* the [adenylate cyclase] activity in membrane preparations of ETA expressing cells , indicating the direct linkage of ETA to the adenylate cyclase system . Positive_regulation ADCY3 EPHB2 23800469 2802946 With loss-of-function experiments in the rat neuronal cell line Neuroscreen-1 (NS-1) and gain-of-function experiments in human embryonic kidney 293T cells , we demonstrated that Rapgef2 connected GPCR dependent activation of [adenylate cyclase] and *increased* cAMP concentration with the activation of in neurons and endocrine cells . Positive_regulation ADCY3 GPR115 9753683 534470 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY3 GPR132 9753683 534459 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY3 GPR87 9753683 534539 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY3 IL1B 7506523 239958 Calcitonin (CT) , substance P ( SP ) , , and transforming growth factor-beta 1 ( TGF beta 1 ) *had* no effect on [adenylate cyclase] in either fibroblast . Positive_regulation ADCY3 MAP2K6 17877640 1796488 In one clone ( PC47 ) , ICP10PK inhibited caspase-3 activation through up-regulation/stabilization of [adenylate cyclase (AC)] , *activation* of PKA and , and the convergence of the two pathways on extracellular signal regulated kinase activation . Positive_regulation ADCY3 PTGER2 15947091 1452191 The effect of PGE2 is mediated by *activation* of [adenylate cyclase] via the Gs-protein coupled receptor . Positive_regulation ADCY3 SELL 1521577 197006 Addition of the octapeptide , Met5-enk *resulted* in decreased [adenylate cyclase] activity ; Positive_regulation ADCY3 SRGN 3514598 57796 This method was used to investigate the relationship between the rate of *activation* of [adenylate cyclase] by p ( NH ) and GTP gamma S and their apparent affinities . Positive_regulation ADCY3 SRGN 4039563 48578 p [ NH ] *stimulated* [adenylate cyclase] activity was reconstituted by mixing samples from the gel-filtration column containing Gs with C unit . Positive_regulation ADCY3 SRGN 6249258 11521 3. Trypsin treatment of intact hepatocytes has no effect on the basal , fluoride- , GTP- or p [ NH ] *stimulated* [adenylate cyclase] activity . Positive_regulation ADCY3 SRGN 6298116 25187 In contrast , the GTP analogue p ( NH ) ( guanosine 5'beta , gamma-imido triphosphate ) *caused* a persistent activation of the [adenylate cyclase] . Positive_regulation ADCY3 SRGN 6615475 30626 The lag observed in the p [ NH ] *stimulated* [adenylate cyclase] activity of native membranes was abolished when membranes from glucagon pretreated cells were used . Positive_regulation ADCY4 ADRB2 10950942 723571 A *activates* [adenylate cyclase] in human erythrocyte membranes at physiological calcium plasma concentrations . Positive_regulation ADCY4 ADRB2 1326677 197564 The effects of prostaglandin E2 ( PGE2 ) infusions on lymphocyte *dependent* [adenylate cyclase] ( beta 2ARAC ) system were studied in 26 patients with resistant hypertension ( RH ) . Positive_regulation ADCY4 ADRB2 3034291 73355 Characterization of the *dependent* [adenylate cyclase] of A431 epidermoid carcinoma cells . Positive_regulation ADCY4 ADRB2 7809956 284944 [ The effect of sodium and ouabain on the activation of *dependent* [adenylate cyclase] in human lymphocytes ] . Positive_regulation ADCY4 CDKN1C 11880488 919428 Pituitary [adenylate cyclase] activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is *regulated* by dependent CDK2 activity . Positive_regulation ADCY4 EDN2 10750028 681334 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone , indicating that [adenylate cyclase] and TNFalpha *induce* synthesis by separate signalling pathways . Positive_regulation ADCY4 EDN2 1319997 190053 , added together with GTP , *activated* the [adenylate cyclase] activity in membrane preparations of ETA expressing cells , indicating the direct linkage of ETA to the adenylate cyclase system . Positive_regulation ADCY4 EPHB2 23800469 2802947 With loss-of-function experiments in the rat neuronal cell line Neuroscreen-1 (NS-1) and gain-of-function experiments in human embryonic kidney 293T cells , we demonstrated that Rapgef2 connected GPCR dependent activation of [adenylate cyclase] and *increased* cAMP concentration with the activation of in neurons and endocrine cells . Positive_regulation ADCY4 GPR115 9753683 534564 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY4 GPR132 9753683 534553 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY4 GPR87 9753683 534633 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY4 IL1B 7506523 239960 Calcitonin (CT) , substance P ( SP ) , , and transforming growth factor-beta 1 ( TGF beta 1 ) *had* no effect on [adenylate cyclase] in either fibroblast . Positive_regulation ADCY4 MAP2K6 17877640 1796501 In one clone ( PC47 ) , ICP10PK inhibited caspase-3 activation through up-regulation/stabilization of [adenylate cyclase (AC)] , *activation* of PKA and , and the convergence of the two pathways on extracellular signal regulated kinase activation . Positive_regulation ADCY4 PTGER2 15947091 1452192 The effect of PGE2 is mediated by *activation* of [adenylate cyclase] via the Gs-protein coupled receptor . Positive_regulation ADCY4 SELL 1521577 197009 Addition of the octapeptide , Met5-enk *resulted* in decreased [adenylate cyclase] activity ; Positive_regulation ADCY4 SRGN 3514598 57797 This method was used to investigate the relationship between the rate of *activation* of [adenylate cyclase] by p ( NH ) and GTP gamma S and their apparent affinities . Positive_regulation ADCY4 SRGN 4039563 48579 p [ NH ] *stimulated* [adenylate cyclase] activity was reconstituted by mixing samples from the gel-filtration column containing Gs with C unit . Positive_regulation ADCY4 SRGN 6249258 11522 3. Trypsin treatment of intact hepatocytes has no effect on the basal , fluoride- , GTP- or p [ NH ] *stimulated* [adenylate cyclase] activity . Positive_regulation ADCY4 SRGN 6298116 25188 In contrast , the GTP analogue p ( NH ) ( guanosine 5'beta , gamma-imido triphosphate ) *caused* a persistent activation of the [adenylate cyclase] . Positive_regulation ADCY4 SRGN 6615475 30627 The lag observed in the p [ NH ] *stimulated* [adenylate cyclase] activity of native membranes was abolished when membranes from glucagon pretreated cells were used . Positive_regulation ADCY5 ADRB2 10950942 723572 A *activates* [adenylate cyclase] in human erythrocyte membranes at physiological calcium plasma concentrations . Positive_regulation ADCY5 ADRB2 1326677 197565 The effects of prostaglandin E2 ( PGE2 ) infusions on lymphocyte *dependent* [adenylate cyclase] ( beta 2ARAC ) system were studied in 26 patients with resistant hypertension ( RH ) . Positive_regulation ADCY5 ADRB2 3034291 73356 Characterization of the *dependent* [adenylate cyclase] of A431 epidermoid carcinoma cells . Positive_regulation ADCY5 ADRB2 7809956 284945 [ The effect of sodium and ouabain on the activation of *dependent* [adenylate cyclase] in human lymphocytes ] . Positive_regulation ADCY5 CDKN1C 11880488 919430 Pituitary [adenylate cyclase] activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is *regulated* by dependent CDK2 activity . Positive_regulation ADCY5 EDN2 10750028 681335 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone , indicating that [adenylate cyclase] and TNFalpha *induce* synthesis by separate signalling pathways . Positive_regulation ADCY5 EDN2 1319997 190056 , added together with GTP , *activated* the [adenylate cyclase] activity in membrane preparations of ETA expressing cells , indicating the direct linkage of ETA to the adenylate cyclase system . Positive_regulation ADCY5 EPHB2 23800469 2802948 With loss-of-function experiments in the rat neuronal cell line Neuroscreen-1 (NS-1) and gain-of-function experiments in human embryonic kidney 293T cells , we demonstrated that Rapgef2 connected GPCR dependent activation of [adenylate cyclase] and *increased* cAMP concentration with the activation of in neurons and endocrine cells . Positive_regulation ADCY5 GPR115 9753683 534658 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY5 GPR132 9753683 534647 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY5 GPR87 9753683 534727 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY5 IL1B 7506523 239962 Calcitonin (CT) , substance P ( SP ) , , and transforming growth factor-beta 1 ( TGF beta 1 ) *had* no effect on [adenylate cyclase] in either fibroblast . Positive_regulation ADCY5 MAP2K6 17877640 1796514 In one clone ( PC47 ) , ICP10PK inhibited caspase-3 activation through up-regulation/stabilization of [adenylate cyclase (AC)] , *activation* of PKA and , and the convergence of the two pathways on extracellular signal regulated kinase activation . Positive_regulation ADCY5 PTGER2 15947091 1452193 The effect of PGE2 is mediated by *activation* of [adenylate cyclase] via the Gs-protein coupled receptor . Positive_regulation ADCY5 SELL 1521577 197012 Addition of the octapeptide , Met5-enk *resulted* in decreased [adenylate cyclase] activity ; Positive_regulation ADCY5 SRGN 3514598 57798 This method was used to investigate the relationship between the rate of *activation* of [adenylate cyclase] by p ( NH ) and GTP gamma S and their apparent affinities . Positive_regulation ADCY5 SRGN 4039563 48580 p [ NH ] *stimulated* [adenylate cyclase] activity was reconstituted by mixing samples from the gel-filtration column containing Gs with C unit . Positive_regulation ADCY5 SRGN 6249258 11523 3. Trypsin treatment of intact hepatocytes has no effect on the basal , fluoride- , GTP- or p [ NH ] *stimulated* [adenylate cyclase] activity . Positive_regulation ADCY5 SRGN 6298116 25189 In contrast , the GTP analogue p ( NH ) ( guanosine 5'beta , gamma-imido triphosphate ) *caused* a persistent activation of the [adenylate cyclase] . Positive_regulation ADCY5 SRGN 6615475 30628 The lag observed in the p [ NH ] *stimulated* [adenylate cyclase] activity of native membranes was abolished when membranes from glucagon pretreated cells were used . Positive_regulation ADCY6 ADRB2 10950942 723573 A *activates* [adenylate cyclase] in human erythrocyte membranes at physiological calcium plasma concentrations . Positive_regulation ADCY6 ADRB2 1326677 197566 The effects of prostaglandin E2 ( PGE2 ) infusions on lymphocyte *dependent* [adenylate cyclase] ( beta 2ARAC ) system were studied in 26 patients with resistant hypertension ( RH ) . Positive_regulation ADCY6 ADRB2 3034291 73357 Characterization of the *dependent* [adenylate cyclase] of A431 epidermoid carcinoma cells . Positive_regulation ADCY6 ADRB2 7809956 284946 [ The effect of sodium and ouabain on the activation of *dependent* [adenylate cyclase] in human lymphocytes ] . Positive_regulation ADCY6 CDKN1C 11880488 919432 Pituitary [adenylate cyclase] activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is *regulated* by dependent CDK2 activity . Positive_regulation ADCY6 EDN2 10750028 681336 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone , indicating that [adenylate cyclase] and TNFalpha *induce* synthesis by separate signalling pathways . Positive_regulation ADCY6 EDN2 1319997 190059 , added together with GTP , *activated* the [adenylate cyclase] activity in membrane preparations of ETA expressing cells , indicating the direct linkage of ETA to the adenylate cyclase system . Positive_regulation ADCY6 EPHB2 23800469 2802949 With loss-of-function experiments in the rat neuronal cell line Neuroscreen-1 (NS-1) and gain-of-function experiments in human embryonic kidney 293T cells , we demonstrated that Rapgef2 connected GPCR dependent activation of [adenylate cyclase] and *increased* cAMP concentration with the activation of in neurons and endocrine cells . Positive_regulation ADCY6 GPR115 9753683 534752 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY6 GPR132 9753683 534741 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY6 GPR87 9753683 534821 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY6 IL1B 7506523 239964 Calcitonin (CT) , substance P ( SP ) , , and transforming growth factor-beta 1 ( TGF beta 1 ) *had* no effect on [adenylate cyclase] in either fibroblast . Positive_regulation ADCY6 MAP2K6 17877640 1796527 In one clone ( PC47 ) , ICP10PK inhibited caspase-3 activation through up-regulation/stabilization of [adenylate cyclase (AC)] , *activation* of PKA and , and the convergence of the two pathways on extracellular signal regulated kinase activation . Positive_regulation ADCY6 PTGER2 15947091 1452194 The effect of PGE2 is mediated by *activation* of [adenylate cyclase] via the Gs-protein coupled receptor . Positive_regulation ADCY6 SELL 1521577 197015 Addition of the octapeptide , Met5-enk *resulted* in decreased [adenylate cyclase] activity ; Positive_regulation ADCY6 SRGN 3514598 57799 This method was used to investigate the relationship between the rate of *activation* of [adenylate cyclase] by p ( NH ) and GTP gamma S and their apparent affinities . Positive_regulation ADCY6 SRGN 4039563 48581 p [ NH ] *stimulated* [adenylate cyclase] activity was reconstituted by mixing samples from the gel-filtration column containing Gs with C unit . Positive_regulation ADCY6 SRGN 6249258 11524 3. Trypsin treatment of intact hepatocytes has no effect on the basal , fluoride- , GTP- or p [ NH ] *stimulated* [adenylate cyclase] activity . Positive_regulation ADCY6 SRGN 6298116 25190 In contrast , the GTP analogue p ( NH ) ( guanosine 5'beta , gamma-imido triphosphate ) *caused* a persistent activation of the [adenylate cyclase] . Positive_regulation ADCY6 SRGN 6615475 30629 The lag observed in the p [ NH ] *stimulated* [adenylate cyclase] activity of native membranes was abolished when membranes from glucagon pretreated cells were used . Positive_regulation ADCY7 ADRB2 10950942 723574 A *activates* [adenylate cyclase] in human erythrocyte membranes at physiological calcium plasma concentrations . Positive_regulation ADCY7 ADRB2 1326677 197567 The effects of prostaglandin E2 ( PGE2 ) infusions on lymphocyte *dependent* [adenylate cyclase] ( beta 2ARAC ) system were studied in 26 patients with resistant hypertension ( RH ) . Positive_regulation ADCY7 ADRB2 3034291 73358 Characterization of the *dependent* [adenylate cyclase] of A431 epidermoid carcinoma cells . Positive_regulation ADCY7 ADRB2 7809956 284947 [ The effect of sodium and ouabain on the activation of *dependent* [adenylate cyclase] in human lymphocytes ] . Positive_regulation ADCY7 CDKN1C 11880488 919434 Pituitary [adenylate cyclase] activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is *regulated* by dependent CDK2 activity . Positive_regulation ADCY7 EDN2 10750028 681337 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone , indicating that [adenylate cyclase] and TNFalpha *induce* synthesis by separate signalling pathways . Positive_regulation ADCY7 EDN2 1319997 190062 , added together with GTP , *activated* the [adenylate cyclase] activity in membrane preparations of ETA expressing cells , indicating the direct linkage of ETA to the adenylate cyclase system . Positive_regulation ADCY7 EPHB2 23800469 2802950 With loss-of-function experiments in the rat neuronal cell line Neuroscreen-1 (NS-1) and gain-of-function experiments in human embryonic kidney 293T cells , we demonstrated that Rapgef2 connected GPCR dependent activation of [adenylate cyclase] and *increased* cAMP concentration with the activation of in neurons and endocrine cells . Positive_regulation ADCY7 GPR115 9753683 534846 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY7 GPR132 9753683 534835 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY7 GPR87 9753683 534915 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY7 IL1B 7506523 239966 Calcitonin (CT) , substance P ( SP ) , , and transforming growth factor-beta 1 ( TGF beta 1 ) *had* no effect on [adenylate cyclase] in either fibroblast . Positive_regulation ADCY7 MAP2K6 17877640 1796540 In one clone ( PC47 ) , ICP10PK inhibited caspase-3 activation through up-regulation/stabilization of [adenylate cyclase (AC)] , *activation* of PKA and , and the convergence of the two pathways on extracellular signal regulated kinase activation . Positive_regulation ADCY7 PTGER2 15947091 1452195 The effect of PGE2 is mediated by *activation* of [adenylate cyclase] via the Gs-protein coupled receptor . Positive_regulation ADCY7 SELL 1521577 197018 Addition of the octapeptide , Met5-enk *resulted* in decreased [adenylate cyclase] activity ; Positive_regulation ADCY7 SRGN 3514598 57800 This method was used to investigate the relationship between the rate of *activation* of [adenylate cyclase] by p ( NH ) and GTP gamma S and their apparent affinities . Positive_regulation ADCY7 SRGN 4039563 48582 p [ NH ] *stimulated* [adenylate cyclase] activity was reconstituted by mixing samples from the gel-filtration column containing Gs with C unit . Positive_regulation ADCY7 SRGN 6249258 11525 3. Trypsin treatment of intact hepatocytes has no effect on the basal , fluoride- , GTP- or p [ NH ] *stimulated* [adenylate cyclase] activity . Positive_regulation ADCY7 SRGN 6298116 25191 In contrast , the GTP analogue p ( NH ) ( guanosine 5'beta , gamma-imido triphosphate ) *caused* a persistent activation of the [adenylate cyclase] . Positive_regulation ADCY7 SRGN 6615475 30630 The lag observed in the p [ NH ] *stimulated* [adenylate cyclase] activity of native membranes was abolished when membranes from glucagon pretreated cells were used . Positive_regulation ADCY8 ADRB2 10950942 723575 A *activates* [adenylate cyclase] in human erythrocyte membranes at physiological calcium plasma concentrations . Positive_regulation ADCY8 ADRB2 1326677 197568 The effects of prostaglandin E2 ( PGE2 ) infusions on lymphocyte *dependent* [adenylate cyclase] ( beta 2ARAC ) system were studied in 26 patients with resistant hypertension ( RH ) . Positive_regulation ADCY8 ADRB2 3034291 73359 Characterization of the *dependent* [adenylate cyclase] of A431 epidermoid carcinoma cells . Positive_regulation ADCY8 ADRB2 7809956 284948 [ The effect of sodium and ouabain on the activation of *dependent* [adenylate cyclase] in human lymphocytes ] . Positive_regulation ADCY8 CDKN1C 11880488 919436 Pituitary [adenylate cyclase] activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is *regulated* by dependent CDK2 activity . Positive_regulation ADCY8 EDN2 10750028 681338 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone , indicating that [adenylate cyclase] and TNFalpha *induce* synthesis by separate signalling pathways . Positive_regulation ADCY8 EDN2 1319997 190065 , added together with GTP , *activated* the [adenylate cyclase] activity in membrane preparations of ETA expressing cells , indicating the direct linkage of ETA to the adenylate cyclase system . Positive_regulation ADCY8 EPHB2 23800469 2802951 With loss-of-function experiments in the rat neuronal cell line Neuroscreen-1 (NS-1) and gain-of-function experiments in human embryonic kidney 293T cells , we demonstrated that Rapgef2 connected GPCR dependent activation of [adenylate cyclase] and *increased* cAMP concentration with the activation of in neurons and endocrine cells . Positive_regulation ADCY8 GPR115 9753683 534940 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY8 GPR132 9753683 534929 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY8 GPR87 9753683 535009 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY8 IL1B 7506523 239968 Calcitonin (CT) , substance P ( SP ) , , and transforming growth factor-beta 1 ( TGF beta 1 ) *had* no effect on [adenylate cyclase] in either fibroblast . Positive_regulation ADCY8 MAP2K6 17877640 1796553 In one clone ( PC47 ) , ICP10PK inhibited caspase-3 activation through up-regulation/stabilization of [adenylate cyclase (AC)] , *activation* of PKA and , and the convergence of the two pathways on extracellular signal regulated kinase activation . Positive_regulation ADCY8 PTGER2 15947091 1452196 The effect of PGE2 is mediated by *activation* of [adenylate cyclase] via the Gs-protein coupled receptor . Positive_regulation ADCY8 SELL 1521577 197021 Addition of the octapeptide , Met5-enk *resulted* in decreased [adenylate cyclase] activity ; Positive_regulation ADCY8 SRGN 3514598 57801 This method was used to investigate the relationship between the rate of *activation* of [adenylate cyclase] by p ( NH ) and GTP gamma S and their apparent affinities . Positive_regulation ADCY8 SRGN 4039563 48583 p [ NH ] *stimulated* [adenylate cyclase] activity was reconstituted by mixing samples from the gel-filtration column containing Gs with C unit . Positive_regulation ADCY8 SRGN 6249258 11526 3. Trypsin treatment of intact hepatocytes has no effect on the basal , fluoride- , GTP- or p [ NH ] *stimulated* [adenylate cyclase] activity . Positive_regulation ADCY8 SRGN 6298116 25192 In contrast , the GTP analogue p ( NH ) ( guanosine 5'beta , gamma-imido triphosphate ) *caused* a persistent activation of the [adenylate cyclase] . Positive_regulation ADCY8 SRGN 6615475 30631 The lag observed in the p [ NH ] *stimulated* [adenylate cyclase] activity of native membranes was abolished when membranes from glucagon pretreated cells were used . Positive_regulation ADCY8 TGM2 23200849 2730681 Ga ( h ) activity is *required* for maximal activation of [adenylylcyclase 8] in human and rat glioma cells . Positive_regulation ADCY9 ADRB2 10950942 723576 A *activates* [adenylate cyclase] in human erythrocyte membranes at physiological calcium plasma concentrations . Positive_regulation ADCY9 ADRB2 1326677 197569 The effects of prostaglandin E2 ( PGE2 ) infusions on lymphocyte *dependent* [adenylate cyclase] ( beta 2ARAC ) system were studied in 26 patients with resistant hypertension ( RH ) . Positive_regulation ADCY9 ADRB2 3034291 73360 Characterization of the *dependent* [adenylate cyclase] of A431 epidermoid carcinoma cells . Positive_regulation ADCY9 ADRB2 7809956 284949 [ The effect of sodium and ouabain on the activation of *dependent* [adenylate cyclase] in human lymphocytes ] . Positive_regulation ADCY9 CDKN1C 11880488 919438 Pituitary [adenylate cyclase] activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is *regulated* by dependent CDK2 activity . Positive_regulation ADCY9 EDN2 10750028 681339 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone , indicating that [adenylate cyclase] and TNFalpha *induce* synthesis by separate signalling pathways . Positive_regulation ADCY9 EDN2 1319997 190068 , added together with GTP , *activated* the [adenylate cyclase] activity in membrane preparations of ETA expressing cells , indicating the direct linkage of ETA to the adenylate cyclase system . Positive_regulation ADCY9 EPHB2 23800469 2802952 With loss-of-function experiments in the rat neuronal cell line Neuroscreen-1 (NS-1) and gain-of-function experiments in human embryonic kidney 293T cells , we demonstrated that Rapgef2 connected GPCR dependent activation of [adenylate cyclase] and *increased* cAMP concentration with the activation of in neurons and endocrine cells . Positive_regulation ADCY9 GPR115 9753683 535034 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY9 GPR132 9753683 535023 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY9 GPR87 9753683 535103 The binding of calcitonin to a *activates* [adenylate cyclase] and elevates cytosolic Ca2+ levels . Positive_regulation ADCY9 IL1B 7506523 239970 Calcitonin (CT) , substance P ( SP ) , , and transforming growth factor-beta 1 ( TGF beta 1 ) *had* no effect on [adenylate cyclase] in either fibroblast . Positive_regulation ADCY9 MAP2K6 17877640 1796566 In one clone ( PC47 ) , ICP10PK inhibited caspase-3 activation through up-regulation/stabilization of [adenylate cyclase (AC)] , *activation* of PKA and , and the convergence of the two pathways on extracellular signal regulated kinase activation . Positive_regulation ADCY9 PTGER2 15947091 1452197 The effect of PGE2 is mediated by *activation* of [adenylate cyclase] via the Gs-protein coupled receptor . Positive_regulation ADCY9 SELL 1521577 197024 Addition of the octapeptide , Met5-enk *resulted* in decreased [adenylate cyclase] activity ; Positive_regulation ADCY9 SRGN 3514598 57802 This method was used to investigate the relationship between the rate of *activation* of [adenylate cyclase] by p ( NH ) and GTP gamma S and their apparent affinities . Positive_regulation ADCY9 SRGN 4039563 48584 p [ NH ] *stimulated* [adenylate cyclase] activity was reconstituted by mixing samples from the gel-filtration column containing Gs with C unit . Positive_regulation ADCY9 SRGN 6249258 11527 3. Trypsin treatment of intact hepatocytes has no effect on the basal , fluoride- , GTP- or p [ NH ] *stimulated* [adenylate cyclase] activity . Positive_regulation ADCY9 SRGN 6298116 25193 In contrast , the GTP analogue p ( NH ) ( guanosine 5'beta , gamma-imido triphosphate ) *caused* a persistent activation of the [adenylate cyclase] . Positive_regulation ADCY9 SRGN 6615475 30632 The lag observed in the p [ NH ] *stimulated* [adenylate cyclase] activity of native membranes was abolished when membranes from glucagon pretreated cells were used . Positive_regulation ADCYAP1 EPHB2 11453643 837000 We have recently shown that in PC12 cells , PACAP and NGF synergistically increase [PACAP] gene transcription and mRNA level , and that the kinase inhibitor PD98059 *blocks* the PACAP mRNA expression induced by either PACAP or NGF , but not that induced by the combination , suggesting involvement of multiple signaling pathways . Positive_regulation ADCYAP1 EPHB2 11453643 837015 These results indicate that PACAP receptors are coupled to the p38 signaling pathway , and that p38 plays a key role in the regulation of PACAP gene expression , while , but not p38 , MAPK is *involved* in [PACAP] and NGF induced neurite outgrowth . Positive_regulation ADCYAP1 IL1B 16095565 1448114 Furthermore , stimulated IL-6 promoter activity in the osteoblastic cell line MC3T3-E1 stably transfected with a human IL-6 promoter/luciferase construct , and both VIP , and the related neuropeptide [PACAP-38] , *increased* the effect of IL-1beta in a synergistic manner . Positive_regulation ADCYAP1 MAP2K6 17596563 1792491 The inhibitor , U0126 , and the PKA inhibitors , H89 and cAMP dependent protein kinase peptide inhibitor ( PKI ) , completely *inhibited* MAPK3/1 activation by either [ADCYAP1] or CPT-cAMP . Positive_regulation ADCYAP1 PLAT 21919910 2506843 In this study , we show that , in PC12 cells , [PACAP] *induced* a 9.85-fold increase in gene expression through activation of the protein kinase A- and protein kinase C-dependent signaling pathways . Positive_regulation ADH1B ALDH2 23213683 2705692 [ADH1B] * 1 and * 2 allele can *increase* the risk of EC in china , which can be modified by alcohol consumption . Positive_regulation ADH1C CEBPA 8634148 361972 The [ADH3] promoter was not greatly *stimulated* by , despite good binding of C/EBP alpha . Positive_regulation ADH5 ADH1C 11073833 748798 Because formaldehyde exposure has been shown to induce pathological changes in human oral mucosa , eg , micronuclei , the potential enzymatic defense by *dependent* [formaldehyde dehydrogenase] was characterized in oral tissue specimens and cell lines using RNA hybridization and immunological methods as well as enzyme activity measurements . Positive_regulation ADH5 ADH1C 11740346 886787 The ADH3 gene encodes *dependent* [formaldehyde dehydrogenase] , the ancestral and most conserved form of alcohol dehydrogenase . Positive_regulation ADH5 FHL1 11959127 931362 These results suggest that , at slightly alkaline pH , H2 production and [Fdh-H] activity are *dependent* on both the F0F1-ATPase and a novel , designated FHL-2 , which is composed of Hyd-4 and Fdh-H , and is driven by a proton gradient established by the F0F1-ATPase . Positive_regulation ADI1 AGR2 20097405 2219171 The results indicate that an of 10t H ( 2 ) SO ( 4 ) /ha/year is conservative and a suitable cover design *target* for [ARD] control that would be matched by ANRnc . Positive_regulation ADIPOQ EPHB2 20339310 2401325 The inhibitory effects of PKC? on [adiponectin] expression is *mediated* by in 3T3-L1 adipocytes . Positive_regulation ADIPOQ FOXO1 22342903 2668823 [Adiponectin] levels are also *stimulated* by and AMP activated protein kinase (AMPK) , and are suppressed by PKA or silencing mediator of retinoid and thyroid hormone receptors ( SMRT ) . Positive_regulation ADIPOQ MAP2K6 23490586 2818597 Adipose tissue activity can differentially *regulate* [adiponectin] gene expression and protein abundance and its suppression in obesity may play a mechanistic role in obesity related plasma adiponectin decline . Positive_regulation ADIPOQ MMP28 24255018 2904099 [Adiponectin] *mediated* APPL1-AMPK signaling induces cell migration , activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation ADIPOQ MMP7 24255018 2904114 [Adiponectin] *mediated* APPL1-AMPK signaling induces cell migration , activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation ADIPOQ TNF 15629137 1362201 In the present study , the mechanism by which [adiponectin] is *regulated* by was investigated . Positive_regulation ADIPOQ TNF 15850785 1399362 The aims of the present study were : ( 1 ) to identify the promoter region responsible for basal transcription of the human adiponectin gene , and ( 2 ) to investigate the mechanism by which [adiponectin] was *regulated* by . Positive_regulation ADIPOQ TNF 16586095 1574800 decreased adiponectin , adipsin , haptoglobin and leptin mRNA levels by 24 h , but [adiponectin] and haptoglobin mRNA was initially *increased* . Positive_regulation ADIPOQ TNF 17080243 1654924 the mRNA expression of , TGF-beta(1) , and type I procollagen decreased , but the expression of [adiponectin] *increased* significantly , compared with that in the model group . Positive_regulation ADIPOQ TNF 18535101 1965732 [Adiponectin] and leptin , and adipocyte-specific genes of adiponectin , leptin , and PPAR-gamma were *detected* in culture assembly , whereas the lipogenesis factor insulin ( 20 mU/ml ) and inflammation related agent ( 2 nm ) increased and decreased , respectively , all of their displays . Positive_regulation ADIPOQ TNF 20089616 2206064 The net change in [adiponectin] secretion in *response* to IL-6 , monocyte chemoattractant protein-1 , and differed between PCOS ( decreasing ) and control ( increasing ) adipocytes , although the difference reached significance only for TNF-alpha ( P < 0.04 ) . Positive_regulation ADIPOQ TNF 20376096 2266841 The anti-steatohepatitis action of PPARgamma was also mediated via regulating adipokines through suppressing and interleukin-6 (IL-6) and *inducing* [adiponectin] . Positive_regulation ADIPOQ TNF 22293775 2551793 ?-Tocotrienol attenuates *induced* changes in secretion and gene expression of MCP-1 , IL-6 and [adiponectin] in 3T3-L1 adipocytes . Positive_regulation ADIPOQ TNF 22293775 2551796 ?-tocotrienol effectively improved the *induced* adverse changes in MCP-1 , IL-6 and adiponectin secretion , and in MCP-1 , IL-6 , [adiponectin] and PPAR? mRNA expression . Positive_regulation ADIPOQ TNF 22424696 2588098 [Adiponectin] *induces* CCL20 expression synergistically with IL-6 and in THP-1 macrophages . Positive_regulation ADIPOQ TNF 22744305 2644410 Stimulation of human adipocytes with a over 6 and 24 h *resulted* in a significant decrease in [adiponectin] mRNA transcripts . Positive_regulation ADIPOR1 FOXO1 20125105 2248421 may *contribute* to enhanced [ADIPOR1] , but not ADIPOR2 transcription in IR . Positive_regulation ADIPOR2 FOXO1 20125105 2248422 may *contribute* to enhanced ADIPOR1 , but not [ADIPOR2] transcription in IR . Positive_regulation ADIPOR2 FOXO1 21194380 2443137 *Role* of signaling in dietary saturated fat dependent upregulation of liver [adiponectin receptor 2] in ethanol administered mice . Positive_regulation ADK TCN1 3698043 58993 A *requirement* for [adenosine kinase] activity for activation of both TCN and was established by the observation that growth inhibition by either compound was decreased 200-fold by the adenosine kinase inhibitor 5-iodotubercidin and greater than 5000-fold in L1210/T , an adenosine kinase-deficient subline . Positive_regulation ADM IL1B 10764953 684163 Interferon-gamma ( 100 U/ml ) increased the immunoreactive-endothelin levels , but not immunoreactive-adrenomedullin levels , whereas ( 10 ng/ml ) *increased* [immunoreactive-adrenomedullin] levels , but not immunoreactive-endothelin levels . Positive_regulation ADM IL1B 15930287 1414462 The proinflammatory cytokine and hypoxia cooperatively *induce* the expression of [adrenomedullin] in ovarian carcinoma cells through hypoxia inducible factor 1 activation . Positive_regulation ADM IL1B 15930287 1414477 Finally , treatment of HIF-1alpha with short interfering RNA revealed a significant role for HIF-1 in the *dependent* stimulation of [ADM] expression . Positive_regulation ADM RGS2 24154573 2885760 The vascular activities of [adrenomedullin (ADM)] and adrenotension ( ADT ) , two natural peptides , are *dependent* upon the modulation of expression . Positive_regulation ADM TNF 16622024 1551536 [ADM] secretion was *regulated* by . Positive_regulation ADM TNF 17688793 1781870 To investigate the reversal of multidrug resistance in the cell line [HepG2/ADM] *induced* by . Positive_regulation ADM TNF 18036803 1852190 *induced* [ADM] expression in both cell types by 2-10-fold . Positive_regulation ADM TNF 22956308 2726593 As also increases ADM levels in the epididymal fat and the soleus muscle and EDN-1 also *increases* [ADM] levels in the epididymal fat , they may form a feedback loop with ADM in these tissues . Positive_regulation ADM TNF 23918941 2826095 Both RANTES and *induce* [ADM] through activation of nuclear factor ?B and its target genes involved in regulating survival , proliferation , and degradation of extracellular matrix . Positive_regulation ADM TNF 7857273 294849 Interleukin-1 , and lipopolysaccharide additively *stimulate* production of [adrenomedullin] in vascular smooth muscle cells . Positive_regulation ADORA1 EPHB2 15485865 1342617 G16 mediated activation of nuclear factor kappaB by the [adenosine A1 receptor] *involves* c-Src , protein kinase C , and signaling . Positive_regulation ADORA2B NT5E 24262796 2916599 Taken together , these findings implicate *dependent* production of extracellular adenosine and endothelial [Adora2b] signaling in kidney protection during diabetic nephropathy . Positive_regulation ADRA1B EDN2 10686290 669842 Activation of G ( q ) -coupled receptors , such as the ET ( A ) receptor *induces* [alpha(1B)-adrenoceptor] phosphorylation and desensitization . Positive_regulation ADRA1B MAP2K6 11700022 878446 JNK activation by the [alpha1B-adrenergic receptor/Galphaq] was selectively *mediated* by 4 ( MKK4 ) , but not MKK7 . Positive_regulation ADRA1D EDN2 11171057 783738 Evidence of cross-talk of alpha ( 1d ) -adrenoceptors with receptors endogenously expressed in rat-1 fibroblasts was given by the ability of , lysophosphatidic acid and bradykinin to *induce* [alpha(1d)-adrenoceptor] phosphorylation . Positive_regulation ADRA2A RGS16 19225179 2061796 protein suppression of Galphao protein *mediated* [alpha2A adrenergic receptor] inhibition of mouse hippocampal CA3 epileptiform activity . Positive_regulation ADRA2A RGS2 19225179 2061797 protein suppression of Galphao protein *mediated* [alpha2A adrenergic receptor] inhibition of mouse hippocampal CA3 epileptiform activity . Positive_regulation ADRB2 ADRB1 23373597 2770716 In MRA , signalled through cAMP , Adrb3 through both cAMP and cGMP , but [Adrb2] , did not *activate* nucleotide formation ; Positive_regulation ADRB2 AKAP12 24058627 2846566 , an A-kinase anchoring protein , *targets* protein kinase A (PKA) , protein kinase C ( PKC ) , calcineurin and other signaling molecules to the [beta2-adrenergic receptor] ( ß2-AR ) . Positive_regulation ADRB2 ARRB1 12509508 1038731 is *required* for internalization and mitogen activated protein (MAP) kinase activation by the [beta2 adrenergic receptor (beta2AR)] . Positive_regulation ADRB2 BTRC 19864009 2196890 [beta(2)-Adrenoceptor] agonist dependent inhibition of K ( Ca ) 3.1 ion channels and HLMC mediator release was markedly attenuated in the *presence* of . Positive_regulation ADRB2 CUL1 19864009 2196891 [beta(2)-Adrenoceptor] agonist dependent inhibition of K ( Ca ) 3.1 ion channels and HLMC mediator release was markedly attenuated in the *presence* of . Positive_regulation ADRB2 EPO 34369 8567 These data suggest a possible involvement of [beta2-adrenoceptor] *activation* of production . Positive_regulation ADRB2 EXT1 18583384 1959335 Interestingly , did not *prevent* diabetes induced reduction in [beta(2)-adrenoceptor] or the increase of beta(3)-adrenoceptor expression . Positive_regulation ADRB2 EXT2 18583384 1959336 Interestingly , did not *prevent* diabetes induced reduction in [beta(2)-adrenoceptor] or the increase of beta(3)-adrenoceptor expression . Positive_regulation ADRB2 EXT3 18583384 1959337 Interestingly , did not *prevent* diabetes induced reduction in [beta(2)-adrenoceptor] or the increase of beta(3)-adrenoceptor expression . Positive_regulation ADRB2 GNB1 11882919 919678 *contribute* to the coupling specificity of the [beta2-adrenergic receptor] to G ( s ) . Positive_regulation ADRB2 GNB1 8120045 250977 GRK5 phosphorylation of rhodopsin or [beta 2-adrenergic receptor] is not *stimulated* by . Positive_regulation ADRB2 GNG2 11882919 919679 *contribute* to the coupling specificity of the [beta2-adrenergic receptor] to G ( s ) . Positive_regulation ADRB2 GNG2 8120045 250978 GRK5 phosphorylation of rhodopsin or [beta 2-adrenergic receptor] is not *stimulated* by . Positive_regulation ADRB2 GRK5 19092051 2036029 However , tyrosyl phosphorylation of GRK5 was not necessary for *mediated* phosphorylation of the [beta(2)-adrenergic receptor] , even though beta(2)-adrenergic receptor activation promoted tyrosyl phosphorylation of GRK5 in smooth muscle cells . Positive_regulation ADRB2 GRK5 19092051 2036031 We conclude that GRK5 tyrosyl phosphorylation is required for the *activation* of by the PDGFRbeta , but not by the [beta(2)-adrenergic receptor] , and that by activating GRK5 , the PDGFRbeta triggers its own desensitization . Positive_regulation ADRB2 GRK6 9341194 458714 When assayed in COS-1 cells *promoted* minimal agonist dependent sequestration of the [beta2-adrenergic receptor] , while sequestration was significantly increased in cells expressing either wild-type GRK6 or GRK6-GG . Positive_regulation ADRB2 IL1B 11238007 790433 *enhances* [beta2-adrenergic receptor] expression in human airway epithelial cells by activating PKC . Positive_regulation ADRB2 IL1B 15833737 1417989 differentially *regulates* [beta2 adrenoreceptor] and prostaglandin E2-mediated cAMP accumulation and chloride efflux from Calu-3 bronchial epithelial cells . Positive_regulation ADRB2 INS 11782469 916664 *stimulates* phosphorylation of the [beta 2-adrenergic receptor] by the insulin receptor , creating a potent feedback inhibitor of its tyrosine kinase . Positive_regulation ADRB2 INS 11809767 928865 Akt mediates sequestration of the [beta(2)-adrenergic receptor] in *response* to . Positive_regulation ADRB2 INS 11809767 928867 The counterregulation of catecholamine action by insulin includes *stimulated* sequestration of the [beta(2)-adrenergic receptor] . Positive_regulation ADRB2 INS 11809767 928868 Inhibition of 1-phosphatidylinositol 3-kinase by LY294002 blocks *induced* sequestration of the [beta(2)-adrenergic receptor] , implicating Akt in downstream signaling to the beta(2)-adrenergic receptor . Positive_regulation ADRB2 INS 11809767 928869 Expression of the dominant negative version of Akt ( K179A/T308A/S473A ) , in contrast , abolishes both insulin counterregulation of the cyclic AMP response as well as *stimulated* sequestration of the [beta(2)-adrenergic receptor] . Positive_regulation ADRB2 INS 12429837 1015058 pp60Src mediates *stimulated* sequestration of the [beta(2)-adrenergic receptor] : insulin stimulates pp60Src phosphorylation and activation . Positive_regulation ADRB2 INS 12429837 1015060 Inhibition of Src with PP2 , like the inhibition of phosphatidylinositol 3-kinase with LY294002 [ 2- ( 4-morpholynyl ) -8-phenyl-4H-1-benzopyran-4-one ] , blocked the activation of Src as well as *stimulated* sequestration of the [beta(2)-adrenergic receptor] . Positive_regulation ADRB2 LEP 19876773 2333618 In epididymal adipose tissue , *increased* expression of lipolysis marker [ADRB2] and thermogenesis marker MFN2 and decreased expression of adipogenic markers , FASN , SLC2A4 , and SCD1 , whereas ghrelin increased expression of FASN and SCD1 . Positive_regulation ADRB2 MAGI3 20353789 2260864 [Beta-2 adrenergic receptor] mediated ERK activation is *regulated* by interaction with . Positive_regulation ADRB2 NGF 9349525 460766 Using a human cell line , ODM-2 , derived from the nonpigmented ciliary epithelium , we demonstrate that ( 1 ) NT expression is highly activated by , glucocorticoid , and activators of adenylate cyclase; (2) NTr expression is *up-regulated* by selective ligand activated [beta2-adrenergic receptor] ; Positive_regulation ADRB2 NOX1 19330844 2141808 [beta2 Adrenergic receptor] activation *induces* microglial activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway . Positive_regulation ADRB2 NOX3 19330844 2141809 [beta2 Adrenergic receptor] activation *induces* microglial activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway . Positive_regulation ADRB2 NOX4 19330844 2141810 [beta2 Adrenergic receptor] activation *induces* microglial activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway . Positive_regulation ADRB2 NOX5 19330844 2141807 [beta2 Adrenergic receptor] activation *induces* microglial activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway . Positive_regulation ADRB2 PAQR3 19884349 2188108 Overexpression of impedes the interaction of G betagamma with GRK2 , abrogates the ligand induced change of subcellular distribution of GRK2 , *reduces* isoproterenol stimulated phosphorylation of the [beta2-adrenergic receptor (beta 2AR)] , and alters beta 2AR desensitization . Positive_regulation ADRB2 PRKACB 15381255 1298661 Recently , it has been shown that *mediated* phosphorylation of the [beta(2)-adrenergic receptor] ( beta ( 2 ) -AR ) by the cyclic AMP dependent protein kinase (PKA) reduces its affinity for G ( s ) and increases its affinity for G ( i ) . Positive_regulation ADRB2 PRKACB 18838481 2012907 The inefficient G ( i ) signaling with the R , R isomers is not caused by the inability of the R , R isomers to trigger the *mediated* phosphorylation of the [beta(2)-adrenoceptor] , because the R , R isomers also markedly increased phosphorylation of the receptor at serine 262 by PKA . Positive_regulation ADRB2 PRKACB 9918542 587651 In attempting to characterize the *role* of in regulating the [beta-2 adrenergic receptor (AR)] in human airway cells , we observed a seemingly profound capacity of the isoquinoline H-89 , a potent and widely used PKA inhibitor , to attenuate agonist mediated desensitization of the beta-2 AR . Positive_regulation ADRB2 PRKACG 15381255 1298662 Recently , it has been shown that *mediated* phosphorylation of the [beta(2)-adrenergic receptor] ( beta ( 2 ) -AR ) by the cyclic AMP dependent protein kinase (PKA) reduces its affinity for G ( s ) and increases its affinity for G ( i ) . Positive_regulation ADRB2 PRKACG 18838481 2012908 The inefficient G ( i ) signaling with the R , R isomers is not caused by the inability of the R , R isomers to trigger the *mediated* phosphorylation of the [beta(2)-adrenoceptor] , because the R , R isomers also markedly increased phosphorylation of the receptor at serine 262 by PKA . Positive_regulation ADRB2 PRKACG 9918542 587652 In attempting to characterize the *role* of in regulating the [beta-2 adrenergic receptor (AR)] in human airway cells , we observed a seemingly profound capacity of the isoquinoline H-89 , a potent and widely used PKA inhibitor , to attenuate agonist mediated desensitization of the beta-2 AR . Positive_regulation ADRB2 PRKAR1A 15381255 1298663 Recently , it has been shown that *mediated* phosphorylation of the [beta(2)-adrenergic receptor] ( beta ( 2 ) -AR ) by the cyclic AMP dependent protein kinase (PKA) reduces its affinity for G ( s ) and increases its affinity for G ( i ) . Positive_regulation ADRB2 PRKAR1A 18838481 2012909 The inefficient G ( i ) signaling with the R , R isomers is not caused by the inability of the R , R isomers to trigger the *mediated* phosphorylation of the [beta(2)-adrenoceptor] , because the R , R isomers also markedly increased phosphorylation of the receptor at serine 262 by PKA . Positive_regulation ADRB2 PRKAR1A 9918542 587653 In attempting to characterize the *role* of in regulating the [beta-2 adrenergic receptor (AR)] in human airway cells , we observed a seemingly profound capacity of the isoquinoline H-89 , a potent and widely used PKA inhibitor , to attenuate agonist mediated desensitization of the beta-2 AR . Positive_regulation ADRB2 PRKAR1B 15381255 1298664 Recently , it has been shown that *mediated* phosphorylation of the [beta(2)-adrenergic receptor] ( beta ( 2 ) -AR ) by the cyclic AMP dependent protein kinase (PKA) reduces its affinity for G ( s ) and increases its affinity for G ( i ) . Positive_regulation ADRB2 PRKAR1B 18838481 2012910 The inefficient G ( i ) signaling with the R , R isomers is not caused by the inability of the R , R isomers to trigger the *mediated* phosphorylation of the [beta(2)-adrenoceptor] , because the R , R isomers also markedly increased phosphorylation of the receptor at serine 262 by PKA . Positive_regulation ADRB2 PRKAR1B 9918542 587654 In attempting to characterize the *role* of in regulating the [beta-2 adrenergic receptor (AR)] in human airway cells , we observed a seemingly profound capacity of the isoquinoline H-89 , a potent and widely used PKA inhibitor , to attenuate agonist mediated desensitization of the beta-2 AR . Positive_regulation ADRB2 PRKAR2A 15381255 1298665 Recently , it has been shown that *mediated* phosphorylation of the [beta(2)-adrenergic receptor] ( beta ( 2 ) -AR ) by the cyclic AMP dependent protein kinase (PKA) reduces its affinity for G ( s ) and increases its affinity for G ( i ) . Positive_regulation ADRB2 PRKAR2A 18838481 2012911 The inefficient G ( i ) signaling with the R , R isomers is not caused by the inability of the R , R isomers to trigger the *mediated* phosphorylation of the [beta(2)-adrenoceptor] , because the R , R isomers also markedly increased phosphorylation of the receptor at serine 262 by PKA . Positive_regulation ADRB2 PRKAR2A 9918542 587655 In attempting to characterize the *role* of in regulating the [beta-2 adrenergic receptor (AR)] in human airway cells , we observed a seemingly profound capacity of the isoquinoline H-89 , a potent and widely used PKA inhibitor , to attenuate agonist mediated desensitization of the beta-2 AR . Positive_regulation ADRB2 PRKAR2B 15381255 1298666 Recently , it has been shown that *mediated* phosphorylation of the [beta(2)-adrenergic receptor] ( beta ( 2 ) -AR ) by the cyclic AMP dependent protein kinase (PKA) reduces its affinity for G ( s ) and increases its affinity for G ( i ) . Positive_regulation ADRB2 PRKAR2B 18838481 2012912 The inefficient G ( i ) signaling with the R , R isomers is not caused by the inability of the R , R isomers to trigger the *mediated* phosphorylation of the [beta(2)-adrenoceptor] , because the R , R isomers also markedly increased phosphorylation of the receptor at serine 262 by PKA . Positive_regulation ADRB2 PRKAR2B 9918542 587656 In attempting to characterize the *role* of in regulating the [beta-2 adrenergic receptor (AR)] in human airway cells , we observed a seemingly profound capacity of the isoquinoline H-89 , a potent and widely used PKA inhibitor , to attenuate agonist mediated desensitization of the beta-2 AR . Positive_regulation ADRB2 RHO 15709741 1373297 Light-driven *activation* of [beta 2-adrenergic receptor] signaling by a chimeric containing the beta 2-adrenergic receptor cytoplasmic loops . Positive_regulation ADRB2 SKP1 19864009 2196889 [beta(2)-Adrenoceptor] agonist dependent inhibition of K ( Ca ) 3.1 ion channels and HLMC mediator release was markedly attenuated in the *presence* of . Positive_regulation ADRB2 SRC 11278940 802949 Agonist triggers tyrosine phosphorylation of the [beta2-adrenergic receptor] and recruitment and *activation* of . Positive_regulation ADRB2 SRC 12429837 1015059 Inhibition of with PP2 , like the inhibition of phosphatidylinositol 3-kinase with LY294002 [ 2- ( 4-morpholynyl ) -8-phenyl-4H-1-benzopyran-4-one ] , *blocked* the activation of Src as well as insulin stimulated sequestration of the [beta(2)-adrenergic receptor] . Positive_regulation ADRB2 SRC 14990578 1243146 Here we used mouse embryonic fibroblast (MEF) cells deficient in Src family tyrosine kinases to examine the *role* of in [beta2-adrenergic receptor] signaling to the MAPK pathway and in receptor internalization . Positive_regulation ADRB2 TFPI 2536230 105791 Withdrawal of vasoconstrictor nerve activity , vascular [beta 2-adrenoceptor] *stimulation* by circulating , and metabolic mechanisms ( in adipose tissue ) may contribute to the vasodilatation . Positive_regulation ADRB2 TNF 9305915 454227 Nuclear run-on assays on isolated nuclei and mRNA stability measurements showed that *increased* both [beta2-adrenoreceptor] gene transcription and beta2-adrenoreceptor mRNA half-life , while beta1- and beta3-adrenoreceptor gene expression was modulated only at the transcriptional level by the cytokine . Positive_regulation ADRB2 UPP1 12792671 1097809 The inhibitory GABA(A) receptor , alpha1 glycine receptor , [beta(2)-adrenergic receptor] and arrestin , opiate receptors and the excitatory metabotropic glutamate receptor ( mGluR1alpha ) are *regulated* by the . Positive_regulation ADRB2 UPP2 12792671 1097810 The inhibitory GABA(A) receptor , alpha1 glycine receptor , [beta(2)-adrenergic receptor] and arrestin , opiate receptors and the excitatory metabotropic glutamate receptor ( mGluR1alpha ) are *regulated* by the . Positive_regulation ADRB3 TNF 10884431 709577 The absence of both receptors or p55 receptor alone *resulted* in a significant reduction in brown adipocyte apoptosis and an increase in [beta(3)-adrenoreceptor] and uncoupling protein-1 expression in obese mice . Positive_regulation ADRBK1 CAPN8 12130691 966697 Moreover , our data demonstrate that oxidative stress may change the functioning of GPCRs via *dependent* regulation of [GRK2] levels . Positive_regulation ADRBK1 EPHB2 22447027 2582908 The extracellular signal regulated kinase *potentiated* activity of the G protein coupled receptor kinase [GRK2] and inhibited neutrophil migration , whereas the MAPK p38 acted as a noncanonical GRK that phosphorylated the formyl peptide receptor FPR1 and facilitated neutrophil migration by blocking GRK2 function . Positive_regulation ADRBK1 MIP 12592402 1064317 We also show that lipopolysaccharide (LPS) activated signaling through the Toll-like receptor (TLR)-4 pathway transcriptionally downregulates the expression of [GRK2] and GRK5 in *response* to . Positive_regulation ADRBK2 ADRB2 12642394 1069377 Desensitization of alpha 2A-adrenoceptor signalling by modest levels of adrenaline is facilitated by *dependent* [GRK3] up-regulation . Positive_regulation ADRBK2 EPHB2 23086955 2706840 We also found that nociceptin induced NOPR mediated JNK but not signaling *requires* Ser-363 , [GRK3] , and Arrestin3 . Positive_regulation ADRM1 TP63 20959455 2357381 Phosphorylated *induces* transcription of [RPN13] , leading to NOS2 protein degradation . Positive_regulation AFAP1L1 MMP28 21516130 2480670 Knocking down the AFAP1L1 gene in sarcoma cells resulted in inhibition of the cell invasion , and forced expression of [AFAP1L1] in immortalized human mesenchymal stem cells *induced* anchorage independent growth and increased cell invasiveness with high activity levels of . Positive_regulation AFAP1L1 MMP7 21516130 2480685 Knocking down the AFAP1L1 gene in sarcoma cells resulted in inhibition of the cell invasion , and forced expression of [AFAP1L1] in immortalized human mesenchymal stem cells *induced* anchorage independent growth and increased cell invasiveness with high activity levels of . Positive_regulation AFF1 ALOX5 25402609 2960359 Surprisingly , a constitutive *activation* of by [MLL-AF4] was inhibited by class I HDAC inhibitors , by relieving inhibitory functions deriving from MLL . Positive_regulation AGA TNF 23685153 2805885 To determine the role of ADA2 , we found that [AGA] *induces* ADA2 expression , ADA2 activity and release , and that TNF-a release is blocked by ADA2 neutralizing antibody or ADA2 siRNA , but not by scrambled siRNA . Positive_regulation AGAP2 UNC5B 18469807 1916591 Thus , [PIKE-L] *acts* as a downstream survival effector for netrin-1 through in the nervous system . Positive_regulation AGO2 MAP2K6 18476811 1933295 Phosphorylation of [Ago2] at serine-387 was significantly induced by treatment with sodium arsenite or anisomycin , and arsenite induced phosphorylation was *inhibited* by a p38 MAPK ( mitogen activated protein kinase ) inhibitor , but not by inhibitors of JNK ( c-Jun N-terminal kinase ) or [ MAPK/ERK ( extracellular-signal regulated kinase ) kinase ] . Positive_regulation AGO2 TNF 7721344 301495 [PPD] and rTNF when added singly *induced* accumulation in monocytes . Positive_regulation AGO2 TNF 9731066 530431 Furthermore , [MAC-PPD] *induced* release from monocytes through interactions with CD14 and , importantly , the addition of sCD14 enhanced this MAC-PPD stimulatory effect . Positive_regulation AGR2 AREG 22184114 2549418 Using two different cell lines in which [AGR2] *induces* expression of either the EGFR ligand or the transcription factor CDX2 , only the highly conserved wild-type carboxyl-terminal KTEL motif results in the appropriate outcome . Positive_regulation AGR2 CD79A 8418053 210480 The strongest salivary antibody response was *induced* by [AgI/II-CTB] conjugate given i.n. , but the addition of CT did not further enhance it . Positive_regulation AGR2 CD79A 9607044 508381 The results showed that [AgI/II] either mixed with or conjugated to rCTB could *induce* both mucosal and systemic IgG antibodies to higher levels than in mice similarly immunized with AgI/II alone . Positive_regulation AGR2 CDX2 22184114 2549417 Using two different cell lines in which [AGR2] *induces* expression of either the EGFR ligand amphiregulin or the transcription factor , only the highly conserved wild-type carboxyl-terminal KTEL motif results in the appropriate outcome . Positive_regulation AGR2 CSF3 7533177 296781 First , both CD40 and [Ag receptor (AgR)] cross linking *induced* purified tonsillar human B lymphocytes to secrete the same pattern of cytokines , including IL-1 beta , IL-6 , IL-10 , granulocyte-macrophage-CSF , and TNF-alpha , whereas IL-1 alpha , IL-2 , IL-3 , IL-4 , IL-5 , IL-7 , , or IFN-gamma were not detected . Positive_regulation AGR2 FOXA2 20048076 2193012 In contrast , EBP1 ablation upregulates AGR2 via Foxa1- and *stimulated* [AGR2] promoter activity and increases metastatic behavior . Positive_regulation AGR2 HRAS 8021500 263069 These events may be important for *activation* of by the [AgR] . Positive_regulation AGR2 IFNG 7533177 296782 First , both CD40 and [Ag receptor (AgR)] cross linking *induced* purified tonsillar human B lymphocytes to secrete the same pattern of cytokines , including IL-1 beta , IL-6 , IL-10 , granulocyte-macrophage-CSF , and TNF-alpha , whereas IL-1 alpha , IL-2 , IL-3 , IL-4 , IL-5 , IL-7 , granulocyte (G)-CSF , or were not detected . Positive_regulation AGR2 IL1A 7533177 296783 First , both CD40 and [Ag receptor (AgR)] cross linking *induced* purified tonsillar human B lymphocytes to secrete the same pattern of cytokines , including IL-1 beta , IL-6 , IL-10 , granulocyte-macrophage-CSF , and TNF-alpha , whereas , IL-2 , IL-3 , IL-4 , IL-5 , IL-7 , granulocyte (G)-CSF , or IFN-gamma were not detected . Positive_regulation AGR2 IL3 7533177 296784 First , both CD40 and [Ag receptor (AgR)] cross linking *induced* purified tonsillar human B lymphocytes to secrete the same pattern of cytokines , including IL-1 beta , IL-6 , IL-10 , granulocyte-macrophage-CSF , and TNF-alpha , whereas IL-1 alpha , IL-2 , , IL-4 , IL-5 , IL-7 , granulocyte (G)-CSF , or IFN-gamma were not detected . Positive_regulation AGR2 IL5 7533177 296785 First , both CD40 and [Ag receptor (AgR)] cross linking *induced* purified tonsillar human B lymphocytes to secrete the same pattern of cytokines , including IL-1 beta , IL-6 , IL-10 , granulocyte-macrophage-CSF , and TNF-alpha , whereas IL-1 alpha , IL-2 , IL-3 , IL-4 , , IL-7 , granulocyte (G)-CSF , or IFN-gamma were not detected . Positive_regulation AGR2 KRAS 8021500 263070 These events may be important for *activation* of by the [AgR] . Positive_regulation AGR2 LIPE 16688223 1570003 Phosphorylation of by Hog1 *leads* to [a G2] arrest essential for cell survival at high osmolarity . Positive_regulation AGR2 MAPK1 15539959 1374860 However , constitutive activation of in post-meiotic , cycling Xenopus egg extracts can *lead* to either [a G2] or M-phase arrest of the cell cycle , depending on the timing of p42MAPK activation . Positive_regulation AGR2 NRAS 8021500 263071 These events may be important for *activation* of by the [AgR] . Positive_regulation AGR2 OPRM1 8206835 261225 The induction pattern of MOA catabolism shown by strain NT1 harboring the MOP cyclase-deficient pYDPH208 suggests that [AGR] is converted into MOP by MOP cyclase and that , but not AGR , *induces* catabolism of MOA . Positive_regulation AGR2 PAN2 8440343 213300 PM , but not 6-DMAP or , inhibited [ 14C ] leucine incorporation , *induced* a time related cytotoxic effect , [a G2-arrest] , a metaphase-mitotic-arrest , apoptosis and c-myc mRNA superinduction . Positive_regulation AGR2 PAN3 8440343 213301 PM , but not 6-DMAP or , inhibited [ 14C ] leucine incorporation , *induced* a time related cytotoxic effect , [a G2-arrest] , a metaphase-mitotic-arrest , apoptosis and c-myc mRNA superinduction . Positive_regulation AGR2 PTPRC 1431097 202780 Based on this observation , experiments were designed to examine the *role* of in regulation of [AgR] complex phosphorylation . Positive_regulation AGR2 SETD2 23712868 2870493 [AGR2] expression is *regulated* by and contributes to growth and angiogenesis of glioblastoma . Positive_regulation AGR2 SETD2 23712868 2870496 Expression of the oxygen dependent degradation domain mutant in cells *resulted* in elevated [AGR2] levels and an increased ability to induce HUVEC migration and tube formation in vitro and enhanced growth and vascularity of tumor xenografts in vivo , which were prevented by AGR2 knockdown . Positive_regulation AGR2 SETD2 23712868 2870497 Taken together , these results indicate that [AGR2] expression is *regulated* by and plays an important role in control of glioblastoma growth and vascularity . Positive_regulation AGR2 TFPI 6841561 27880 With glucose levels matched at 256 +/- 5 mg/dl , a similar dose related *enhancement* of [AGR] by was seen ( control , 53 +/- 12 pg/ml ; low EPI , 63 +/- 5 pg/ml ; high EPI , 130 +/- 20 pg/ml ; Positive_regulation AGR2 TP53 16456545 1528198 Active p38 MAP kinase promotes [a G2/M] cell cycle checkpoint through the phosphorylation and *activation* of in these cells in vivo . Positive_regulation AGR2 YAP1 21454516 2427726 Additional experiments demonstrate that [AGR2] induction of AREG is *mediated* by activation of the Hippo signaling pathway co-activator , . Positive_regulation AGT EPHB2 19765632 2183491 Early activation is *involved* in [AGT] upregulation and sustained ERK activation , mediated via AT1 , is responsible for VEGF synthesis . Positive_regulation AGT MAP2K6 20686488 2340708 Furthermore , the H2O2 induced upregulation of [angiotensinogen] was *inhibited* by a mitogen activated protein kinase (MAPK) kinase ( ) inhibitor and a c-Jun N-terminal kinase (JNK) inhibitor , but not inhibited by a p38 MAPK inhibitor . Positive_regulation AGT TNF 15837949 1397974 also *increased* [angiotensinogen] and angiotensin II in isolated adipocytes . Positive_regulation AGT TNF 8613256 353487 *activates* [angiotensinogen] gene expression by the Rel A transactivator . Positive_regulation AGT TNF 8613256 353488 [Angiotensinogen] transcription is *increased* by the inflammatory cytokine by a nuclear factor-kappaB-like protein binding to an inducible enhancer called the acute-phase response element . Positive_regulation AGT TNF 9336385 458161 Therefore , the increased mRNA expression may be *involved* in the increased lipopolysaccharide induced expression of [angiotensinogen] gene in fat of SHR at 13 weeks of age . Positive_regulation AGTR1 EPHB2 21791939 2524128 phosphorylation might *mediate* [angiotensin II type 1 receptor] activation . Positive_regulation AGTR1 IL1B 19040799 2086117 [Angiotensin II receptor] 1 involved in the central pressor response *induced* by in the paraventricular nucleus . Positive_regulation AGTR1 IL1B 19040799 2086119 To investigate the possible participation of [angiotensin II receptor] 1 ( AT(1) receptor ) in pressor response *induced* by in the paraventricular nucleus ( PVN ) of hypothalamus . Positive_regulation AGTR1 SRGN 24508802 2918778 In the *presence* of , NaHS [at 1] .5mM , but not 0.1-0.3mM , increased T-currents in Cav3 .2-HEK293 cells . Positive_regulation AGTR1 TNF 10229121 610978 levels *increased* significantly in the injured cortex [at 1] and 4 , but not at 12 , 24 or 72 h after severe lateral fluid-percussion trauma ( 2.6-2.7 atm ) . Positive_regulation AGTR1 TNF 17548252 1752081 The levels of portal vein and plasma ALT *increased* continuously in the I/R group [at 1] and 3 hours of reperfusion compared with the SH group ; Positive_regulation AGTR1 TNF 22714807 2659489 In the PS group , *increased* [at 1] , 3 , and 5 weeks and IL-1ß increased significantly after 1 and 3 weeks of stress , and then decreased to normal levels by 5 weeks . Positive_regulation AGTR1 TNF 9688686 522536 Circulating and myocardial *increased* [at 1] and 2 h , whereas myocardial contractility was depressed at 4 and 6 h. Pretreatment with cycloheximide or dexamethasone abolished the increase in circulating and myocardial TNF-alpha and preserved myocardial contractile function . Positive_regulation AGTR2 ARSA 3194896 101203 While both and Indo significantly inhibited TXB2 synthesis and platelet aggregation , significant reduction of 12-HETE formation [at 2] and 6 h after the administration of the drug , was *detected* only in subjects who ingested ASA . Positive_regulation AGTR2 CAPN8 10535665 562802 Calcium dependent , calpastatin inhibited caseinolysis ( i.e. , calpain-like activity ) was measured in control and exercised rats ( 25 m/min , 0 % grade ) [at 2] , 5 , 15 , 30 , and 60 min. Total activity in skeletal muscle *increased* by 26 % ( 13.2 +/- 1.3 vs. 17.9 +/- 2.2 U/g wet wt . ) Positive_regulation AGTR2 IL1B 19040799 2086118 [Angiotensin II receptor] 1 involved in the central pressor response *induced* by in the paraventricular nucleus . Positive_regulation AGTR2 IL1B 19040799 2086120 To investigate the possible participation of [angiotensin II receptor] 1 ( AT(1) receptor ) in pressor response *induced* by in the paraventricular nucleus ( PVN ) of hypothalamus . Positive_regulation AGTR2 IL1B 8741743 343439 *increased* ACTH levels [at 2] and 3 h. Indomethacin ( 10 mg kg ( -1 ) , i.p. ) prevented the noradrenergic and ACTH responses . Positive_regulation AGTR2 TNF 11501076 581151 Meanwhile , mRNA expression significantly *increased* in liver , lung , intestine , and kidney [at 2] hours , peaking at 8 hours , and a high level was maintained till 24 hours . Positive_regulation AGTR2 TNF 15968724 1423807 The integrated OD ( IOD ) levels of TNFalpha receptor 1 protein expressed in the intestine of mice with GalN/LPS and GalN/ *induced* FHF [at 2] , 6 , 9 , 12 and 24 h after GalN/LPS and GalN/TNFalpha administration were 169.54+/-52.62/905.79+/-111.84 , 11,350.67+/-2 ,133.26/28,160.37+/-4,601.67 , 25,781.00 +/-2,277.75/122,352.30+/-49,412.40 , 5,241.53+/-3,007.24/49,157.93+/-9,804.88 , 7,086.13+/-1,031.15/3,283.45+/-127.67 , respectively , compared with those in control groups ( with NS , LPS and GalN administration , respectively ) . Positive_regulation AGTR2 TNF 16797840 1585855 We found mRNA expression *increased* [at 2h] and was maintained at high levels until 24h after reperfusion . Positive_regulation AGTR2 TNF 24045486 2857365 [At 2] , 4 , 6 , and 8 h , serum cortisol , , and IL-6 concentration *increased* ( P < 0.05 ) by LPS challenge , and there was an interactive effect between LPS challenge and the inclusion of levan-type fructan ( P < 0.05 ) . Positive_regulation AGXT TNF 9714132 527643 Interleukin 1 (IL-1) , but not , *increased* both [SPT] activity and mRNA levels in the liver of intact animals , whereas both IL-1 and tumor necrosis factor increased SPT mRNA levels in HepG2 cells . Positive_regulation AHCTF1 STK39 18083840 1837122 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation AHR ALOX5 7541545 310519 These findings suggest that neutrophil elastase is involved in antigen induced bronchoconstriction and [AHR] *mediated* by neutrophil accumulation and <5-lipoxygenase> products in allergic sheep . Positive_regulation AHR CAPN8 16891617 1632615 Inhibition of activity by the N-benzyloxycarbonyl-Val-Phe-aldehyde ( MDL28170 ) *blocked* the TCDD induced nuclear translocation of [AhR] in Hepa1c1c7 mouse hepatoma cell line . Positive_regulation AHR IL1B 12376343 996768 This study examines the role of intrinsic airway neurons in [airway hyperresponsiveness (AHR)] *induced* by . Positive_regulation AHR IL1B 12376343 996769 The *induced* [AHR] was maintained in tracheal segments cultured for 24 h , a procedure that depletes SP from sensory nerves while maintaining viability of intrinsic airway neurons . Positive_regulation AHR IL1B 15994384 1429805 As *induces* [airway hyperresponsiveness (AHR)] to the tachykinin NK-1 receptor agonist [ Sar9,Met ( O2 ) 11 ] -substance P in human isolated bronchi , the aim of this study was to determine whether IL-1beta was able to induce NGF release from isolated bronchi , and whether NGF might participate into IL-1beta induced AHR . Positive_regulation AHR IL1B 15994384 1429807 [AHR] *induced* by was abolished by a blocking anti-human NGF antibody . Positive_regulation AHR IL1B 19825525 2148943 Dexamethasone not only completely abolished the *induced* [AHR] to bradykinin , but also abrogated the increased mRNA expression for inflammatory mediators , IL-6 , IFN-gamma and Cox-2 . Positive_regulation AHR MUC16 21646808 2442045 We have reported that human bronchial epithelial cells express [AhR] , and AhR activation *induces* production through reactive oxygen species . Positive_regulation AHR MUC16 22500183 2583863 We have previously reported that human bronchial epithelial cells express [AhR] , and AhR activation *induces* production through reactive oxygen species . Positive_regulation AHR NEDD9 19648964 2143276 Here , we show that dioxin mediated activation of [Ahr] *induces* , a member of the Cas protein family recently identified as a metastasis marker . Positive_regulation AHR NEDD9 22665056 2763368 Further , we show that the activation of the [AhR] *increases* the interaction of FAK with the metastatic marker , , and the expression of several integrins . Positive_regulation AHR TNF 11520723 852311 The purpose of this study was to determine whether *contributes* to [airway hyperresponsiveness (AHR)] and migration of polymorphonuclear leukocytes ( PMN ) into the airways following exposure to ozone ( O ( 3 ) ) . Positive_regulation AHR TNF 11520723 852312 Our results indicate that *contributes* to the [AHR] but not the PMN emigration induced by acute O ( 3 ) exposure . Positive_regulation AHR TNF 11751192 889870 gammadelta T cells have been shown to be activated by and to negatively *regulate* [AHR] . Positive_regulation AHR TNF 16159621 1455994 blockade *resulted* in significant inhibition of the late [AHR] without affecting the early AHR , and reduction in airway eosinophilia and inflammation . Positive_regulation AHR TNF 17336618 1707641 However , studies with TNF-deficient or TNF receptor-deficient mice have not produced a clear picture of the *role* of in the [AHR] associated with allergic inflammation in the mouse . Positive_regulation AHR TNF 17336618 1707643 Our findings in mice support the hypothesis that can *promote* the allergic inflammation and [AHR] associated with asthma . Positive_regulation AHR TNF 17372990 1720545 We have investigated the *role* of in mast cell mediated late [airway hyperresponsiveness (AHR)] using mast cell-deficient WBB6F1-W/W ( v ) ( W/W ( v ) ) mice in a murine model of asthma , which exhibits a biphasic increase in AHR . Positive_regulation AHR TNF 18514752 1918459 Here , we investigated the putative involvement of IFNbeta in regulating *induced* [airway hyper-responsiveness (AHR)] , a defining feature of asthma . Positive_regulation AHR TNF 18617548 1954269 [AhR] expression in synovial cells was *up-regulated* by . Positive_regulation AHR TNF 18617548 1954270 *activates* [AhR] expression in RA synovial tissue , and that cigarette smoking and exposure to TCDD enhances RA inflammatory processes . Positive_regulation AHR TNF 20181658 2259186 Taken together , TCDD stimulates expression and secretion of TNF-alpha in adipocytes through activation of [AhR] , ERK1/2 , and JNK , and the secreted *causes* the downregulation of IRbeta , IRS1 , and GLUT4 through TNFR1 , resulting in insulin resistance . Positive_regulation AHR TNF 21854343 2486315 instillation of IgG-IC caused the recruitment of neutrophils and macrophages into the airway and *mediated* late [AHR] , but failed to induce Th2 cell mediated asthmatic phenotypes . Positive_regulation AHR TNF 21854343 2486316 IgG , but not IgE , is the major Ab that induces not only NF-?B activation and NF-?B dependent proinflammatory molecules in the lungs but also subsequent recruitment of inflammatory cells into the airway and *mediated* late [AHR] . Positive_regulation AHR TNF 22502799 2618342 Using SP-A ( -/- ) Kit ( W-sh/W-sh ) mice engrafted with TNF-a ( -/- ) or TNF receptor (TNF-R) ( -/- ) MCs , we found that activation of MCs through the TNF-R , but not MC-derived TNF-a , *leads* to augmented [AHR] during M pneumoniae infection when SP-A is absent . Positive_regulation AHR TNF 23018605 2726855 First- and second-phase late [AHR] is *caused* by and Th2 response , respectively . Positive_regulation AHR TNF 24565903 2924693 significantly *induced* [AHR] along with CYP1A1 and CYP1B1 expression . Positive_regulation AHSA1 EPHB2 12842814 1149643 was not activated by force , but [p38] phosphorylation was *required* for force induced inhibition of SMA expression . Positive_regulation AHSA1 EPHB2 24253595 2910425 The mechanism by which *regulates* JNK and [p38] activity in polyamine depleted IEC-6 cells during apoptosis . Positive_regulation AHSA1 IL1B 10704772 672999 CPI-1189 inhibits *induced* [p38-mitogen] activated protein kinase phosphorylation : an explanation for its neuroprotective properties ? Positive_regulation AHSA1 IL1B 12193729 981519 In contrast , exogenously added TAT-srIkappaBalpha did not inhibit *induced* activation of extracellular signal regulated kinase , c-Jun N-terminal kinase , or [p38] mitogen activated protein kinases or the phosphorylation and degradation of endogenous IkappaBalpha . Positive_regulation AHSA1 IL1B 16002736 1431019 *activates* both [p38] and ERK 1/2 components of the MAPK pathways . Positive_regulation AHSA1 IL1B 16521184 1531269 *activates* p44/42 and [p38] mitogen activated protein kinases via different pathways in cat esophageal smooth muscle cells . Positive_regulation AHSA1 IL1B 18658272 1967182 Neither flagellin nor altered transepithelial fluxes of membrane-impermeant dextran ( 10 kDa ) or lucifer yellow ( mol wt = 457 ) , but both *activated* [p38] , NF-kappaB , and IL-8 secretion . Positive_regulation AHSA1 MAP2K6 10428782 633242 Cell stress and mediated [p38] MAP kinase *activation* inhibit tumor necrosis factor induced IkappaB phosphorylation and NF-kappaB activation . Positive_regulation AHSA1 MAP2K6 24253595 2910431 The mechanism by which *regulates* JNK and [p38] activity in polyamine depleted IEC-6 cells during apoptosis . Positive_regulation AHSA1 PGC 22105890 2599536 Our studies also revealed that overexpression of in cardiomyocytes *inhibited* basal and T3-induced [p38] MAPK phosphorylation . Positive_regulation AHSA1 TNF 12844496 1149750 increased pulmonary endothelial permeability in vitro and *caused* a rapid , sustained increase in endothelial [p38] and extracellular signal regulated kinase MAPK activity . Positive_regulation AHSA1 TNF 16813528 1580727 *mediates* [p38] MAP kinase activation and negatively regulates bone formation at the injured growth plate in rats . Positive_regulation AHSA1 TNF 17070777 1649820 Inhibition of Syk down-regulated *induced* [p38] and p44/42 MAPK phosphorylation and nuclear translocation of p65 NF-kappaB . Positive_regulation AHSA1 TNF 17389591 1735567 RIP1 mediated AIP1 phosphorylation at a 14-3-3 binding site is critical for *induced* [ASK1-JNK/p38] activation . Positive_regulation AHSA1 TNF 21422246 2416762 Interestingly , all PHA-L ( high ) DCs displayed a strongly reduced responsiveness to induced [p38-MAPK] *activation* compared with PHA-L ( low ) DCs , indicating differences in PHA-L binding capacities between DCs with different inflammatory properties . Positive_regulation AHSA1 TNF 23132229 2696481 In addition , H ( 2 ) S inhibited *mediated* activation of [p38] , extracellular-signal regulated kinase and nuclear factor kappa B . Positive_regulation AHSA1 TNF 23835476 2820889 Mlkl-deficient MEFs and macrophages were indistinguishable from wild-type cells in their ability to activate NF-?B , ERK , JNK , and [p38] in *response* to and lipopolysaccharides (LPS) , respectively . Positive_regulation AHSA1 TNF 23855486 2817023 Acacetin suppressed the *induced* phosphorylation of [p38] but did not inhibit TNF-a induced phosphorylations of JNK and ERK . Positive_regulation AIF1 IL1B 16157606 1467448 The macrophage cell line expressed a certain level of endogenous [AIF-1] , which could be *enhanced* by pro-inflammatory cytokines or tumor necrosis factor-alpha and suppressed by anti-inflammatory drug sodium salicylate . Positive_regulation AIF1 TNF 16157606 1467447 The macrophage cell line expressed a certain level of endogenous [AIF-1] , which could be *enhanced* by pro-inflammatory cytokines IL-1beta or and suppressed by anti-inflammatory drug sodium salicylate . Positive_regulation AIF1 TNF 22150368 2531069 On culturing splenocytes stimulated by soluble egg antigen for 72 h , the expression of [AIF-1] in infected mice was suppressed , but *increased* gradually . Positive_regulation AIP IL1B 9812753 408343 L-1 reduced the inhibition of cell proliferation and [AIP] activity *induced* by TNF or in a concentration dependent manner . Positive_regulation AIP TNF 9812753 408342 L-1 reduced the inhibition of cell proliferation and [AIP] activity *induced* by or IL-1 beta in a concentration dependent manner . Positive_regulation AIRE JAG1 17202386 1681044 Work using Aire ( -/- ) mice suggests that [Aire] *induces* ectopic expression of peripheral and promotes their presentation in the thymus . Positive_regulation AIS1 NFASC 22492029 2583483 Our studies reveal that the Purkinje Nfasc is required for AIS maturation and for maintaining stable contacts between basket axon terminals and the Purkinje AIS during pinceau organization , while the basket neuron in combination with Purkinje Nfasc is *required* for proper basket axon collateral outgrowth and targeting to Purkinje [soma/AIS] . Positive_regulation AIS2 NFASC 22492029 2583484 Our studies reveal that the Purkinje Nfasc is required for AIS maturation and for maintaining stable contacts between basket axon terminals and the Purkinje AIS during pinceau organization , while the basket neuron in combination with Purkinje Nfasc is *required* for proper basket axon collateral outgrowth and targeting to Purkinje [soma/AIS] . Positive_regulation AIS3 NFASC 22492029 2583485 Our studies reveal that the Purkinje Nfasc is required for AIS maturation and for maintaining stable contacts between basket axon terminals and the Purkinje AIS during pinceau organization , while the basket neuron in combination with Purkinje Nfasc is *required* for proper basket axon collateral outgrowth and targeting to Purkinje [soma/AIS] . Positive_regulation AKR1B1 TNF 10075698 595011 Osmotic response element is required for the *induction* of [aldose reductase] by . Positive_regulation AKR1C3 TNF 22608768 2681538 Lipopolysaccharides , , IL-1a , and the reagents combination *increased* PTGS2 , PTGES , and [PGFS] mRNA transcription ( P < 0.01 ) , whereas ALOX5 mRNA transcription was increased only by TNF ( P < 0.001 ) . Positive_regulation AKT1 ANGPT1 10585289 571134 Ceramide induced endothelial cell death and abolished *mediated* activation of [Akt] and the effect on cell survival . Positive_regulation AKT1 ANGPT1 10625301 658523 *induced* phosphorylation of the serine-threonine kinase [Akt] at Ser473 in a PI 3'-kinase dependent manner . Positive_regulation AKT1 ANGPT1 12514118 1063779 Treatment of cells with the phosphatidyl-inositol 3-kinase (PI3-K) inhibitor , LY294002 , inhibited *induced* phosphorylation of [Akt] , restored the cleavage of the effector caspase-3 , and reduced the protective effect of Ang-1 against SD-induced toxicity . Positive_regulation AKT1 ANGPT1 16000309 1452799 These data suggested that *dependent* [Akt] phosphorylation through PI 3-kinase leads to the inhibition of JNK phosphorylation . Positive_regulation AKT1 ANGPT1 16679392 1612145 Pretreatment with either DPI or apocynin also significantly attenuated *induced* [Akt] and p44/42 MAPK phosphorylation . Positive_regulation AKT1 ANGPT1 16679392 1612161 Using mouse heart microvascular endothelial cells from wild-type ( WT ) mice and mice deficient in the p47(phox) component of NADPH oxidase ( p47 ( phox-/- ) ) , we found that although *stimulated* intracellular ROS , [Akt] and p42/44 MAPK phosphorylation , and cell migration in WT cells , the responses were strikingly suppressed in cells from the p47 ( phox-/- ) mice . Positive_regulation AKT1 ANGPT1 17965739 1831098 On the other hand , C-18 blocked activation of members of the mitogen activated protein kinase family and of the Ser/Thr kinase [Akt] *induced* by both VEGF and . Positive_regulation AKT1 ANGPT1 18556567 1946038 These alterations led to a significant impairment of *induced* [Akt] and eNOS phosphorylation , along with a remarkable impairment of Ang-1 induced endothelial cell migration and endothelial cell spheroid sprouting . Positive_regulation AKT1 ANGPT1 18565279 1929500 *induced* [Akt] phosphorylation , increased the Bcl-2/Bax ratio , and decreased the activation of caspase-9 and -3 . Positive_regulation AKT1 ANGPT1 19037734 2001600 ANG9-4 blocked mediated Tie2 phosphorylation and downstream [Akt] *activation* . Positive_regulation AKT1 ANGPT1 19615361 2124097 Treatment of HUVECs with the lipid raft disrupting agent methyl-beta-cyclodextrin selectively inhibited *induced* [Akt] phosphorylation , but not Erk1/2 phosphorylation . Positive_regulation AKT1 ANGPT1 20056911 2218423 A soluble form of Tie-2 produced in human umbilical vein endothelial cells was dramatically suppressed by treatment with siRNA-matrix metalloproteinase (MMP) 14 or tissue inhibitor of metalloproteinase 3 , resulting in an increase in cellular fTie-2 and thereby enhancing *dependent* [Akt] phosphorylation and Akt dependent endothelial functions , such as Ang-2 downregulation or an increase of endothelial viability . Positive_regulation AKT1 ANGPT1 20079751 2212515 Examination of downstream signaling revealed inhibition of *dependent* [Akt] phosphorylation . Positive_regulation AKT1 ANGPT1 20079751 2212520 Similar suppression of *dependent* activation of [Akt] by hyperglycemia was observed in large vessel human endothelial cells . Positive_regulation AKT1 ANGPT1 20079751 2212526 Incubation of microvascular endothelial cells with 200 microM palmitic acid significantly inhibited *dependent* [Akt] phosphorylation without affecting phosphorylation of the Tie-2 receptor or of ERK1/2 . Positive_regulation AKT1 ANGPT1 20519501 2289598 However , only *induces* Tie2 dependent [Akt] activation and subsequent survival signaling and endothelial quiescence . Positive_regulation AKT1 ARSA 20640495 2360385 Both SIM and DIP+low-dose *augmented* [Akt] phosphorylation and their effect was additive . Positive_regulation AKT1 BPI 17012258 1629179 , but not control protein thaumatin , *activated* extracellular regulated kinase (ERK) and [AKT] , and increased DNA synthesis in RPE and RPC but not in REC . Positive_regulation AKT1 BPI 18055828 1833395 The authors recently reported that can *induce* ERK1/2 and [Akt] activity and that it increases DNA synthesis in the bovine retinal pigment epithelial (RPE) and pericyte cells . Positive_regulation AKT1 BPI 18055828 1833400 Heparitinase , phosphatidylinositol-specific phospholipase C , and anti-GPC4 antibody suppressed *induced* ERK and [Akt] phosphorylation in bovine RPE . Positive_regulation AKT1 BPI 23740083 2807054 In addition , can inhibit angiogenesis , suppress LPS mediated platelet activation , increase DNA synthesis , and *activate* [ERK/Akt] signaling . Positive_regulation AKT1 C12orf75 22935015 2740235 binds with insulin receptor substrate 4 and *increases* insulin stimulated [phospho-Akt] and regulates AMP activated protein kinase and mammalian target of rapamycin downstream target S6 kinase phosphorylation . Positive_regulation AKT1 CAPN8 23071514 2685942 Pro-death activity of violacein is actually carried out by inhibition of and DAPK1 and *activation* of PKA , [AKT] and PDK , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation AKT1 CAPN8 23455548 2781760 Blocking AKT further increased doxorubicin induced cardiac injuries , suggesting the effects of inhibition may be *mediated* by inactivating the [AKT] signalling . Positive_regulation AKT1 CAPN8 23467348 2750059 BDNF treatment increased phosphorylation of both Akt and ERK , but only the effect on [Akt] was *blocked* by inhibition . Positive_regulation AKT1 CCND1 19114984 2031792 PTK/ZK also induced cell cycle arrest , accompanied by increasing the expression of p27 ( Kip1 ) and downregulation of and cyclin E. PTK/ZK significantly *inhibited* vascular endothelial growth factor ( VEGF ) expression , as well as VEGF simulated cell proliferation and phosphorylation of [Akt] in activated HSCs . Positive_regulation AKT1 CCND1 19935697 2210092 The expression of *required* both EGFR mediated ERK and [AKT] activation . Positive_regulation AKT1 CCND1 22579115 2609550 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated and Cyclin B1 proteins as well as *activation* of [PI3K/Akt] and Raf/MEK/ERK , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation AKT1 CCND1 24737397 2943102 Mechanistically , aberrant PRL-3 expression promoted cell cycle progression and enhanced the antiapoptotic machinery of AML cells to drug cytotoxicity through downregulation of p21 and upregulation of and CDK2 and *activation* of STAT5 and [AKT] . Positive_regulation AKT1 CD14 22561121 2608673 Zaprinast was found to activate ERK1/2 , p38 MAPK , JNK , NF?B , and [PI3K/Akt] , and subsequently , *induce* the mRNA expressions of IL-1a , IL-1ß , TNF-a , CCL2 , CCL4 , CXCL1 , CXCL2 , and . Positive_regulation AKT1 CEACAM6 18159236 1838553 The colonocyte surface level of integrin alpha5 and the activation of [AKT] *increased* progressively with the expression levels of . Positive_regulation AKT1 CEACAM6 18614350 1947296 Suppression of expression using small interfering RNA ( siRNA ) completely reversed migration and invasion of MCF-7 : 5C and MCF-7 : 2A cells and it significantly *reduced* phosphorylated [Akt] and c-Src expression in these cells . Positive_regulation AKT1 CHI3L1 23972995 2836232 We also demonstrate that *activates* macrophage mitogen activated protein kinase , [protein kinase B/AKT] , and Wnt/ß-catenin signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation AKT1 CLU 21270507 2387619 The protective effect of clusterin on H2O2 induced apoptosis is impaired by PI3K inhibitor LY294002 , which effectively suppresses induced *activation* of [Akt] and GSK-3ß . Positive_regulation AKT1 CLU 22012253 2498762 Secreted , which is selectively increased after transformation , *activates* the survival factor [AKT] , whereas intracellular CLU inhibits the activity of the oncogenic transcription factor nuclear factor kappa B . Positive_regulation AKT1 CLU 24569077 2924722 The phosphorylation of [Akt] *induced* by was blocked by pretreatment with gallein or LY294002 but not with U73122 , indicating that Gß? released from the PTX-sensitive Gi protein complex activated PLC and PI3K/Akt signaling pathways separately . Positive_regulation AKT1 CTGF 12218048 1012157 The inhibition of *induced* p42/44 MAPK or phosphatidylinositol 3-kinase [(PI3K)/protein kinase B] pathway activities abrogated the induction of fibronectin expression . Positive_regulation AKT1 CTGF 16408113 1513470 *enhanced* the mRNA expression and protein release of fractalkine , MCP-1 , and RANTES , the expression of phospho ( P ) -p42/44 mitogen activated protein kinase (MAPK) , P-phosphoinositide 3-kinase (PI3-K) , [P-Akt] , and activity of nuclear factor-kappaB (NF-kappaB) in mesangial cells . Positive_regulation AKT1 CTGF 16408113 1513529 P-PI3-K blockade downregulated the *stimulated* expression of P-PI3-K , [P-Akt] , and NF-kappaB but not P-p42/44 MAPK , and partially decreased the release of the above chemokines . Positive_regulation AKT1 CTGF 16408113 1513538 LXA ( 4 ) dose-dependently inhibited the *stimulated* mRNA expression and protein release of the above chemokines , and the expression of P-p42/44MAPK , P-PI3-K , [P-Akt] , and NF-kappaB . Positive_regulation AKT1 CTGF 16877704 1600901 Most interestingly , overexpression of *suppressed* insulin-like growth factor-I dependent [Akt] phosphorylation and epidermal growth factor dependent extracellular signal regulated kinase 1/2 phosphorylation . Positive_regulation AKT1 CTGF 18375200 1899007 *induces* cardiac hypertrophy through [Akt] signaling . Positive_regulation AKT1 CTGF 20213804 2249220 *induced* phosphorylation of p38 , ERK-1/2 , JNK , and [Akt] , but not Smad3 , in transgenic mouse fibroblasts compared with wild-type mouse fibroblasts . Positive_regulation AKT1 CTGF 22363445 2561520 induced PDGF-B expression in endothelial cells , and *potentiated* PDGF-B mediated [Akt] signaling in mural ( vascular smooth muscle/pericyte ) cells . Positive_regulation AKT1 CTGF 23208610 2745464 Concentration-effect experiments revealed CCN2 stimulated phosphorylation of Akt ( Ser473 ) and downstream GSK-3ß ( Ser9 ) with EC50 ~250 nmol/L. *stimulated* phosphorylation of [Akt] and GSK-3ß was sensitive to inhibition of PI3-kinase ( LY294002 ) . Positive_regulation AKT1 DAPK1 23071514 2685946 Pro-death activity of violacein is actually carried out by inhibition of calpain and and *activation* of PKA , [AKT] and PDK , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation AKT1 EDN2 15860794 1425743 Both MBP1 and *induced* phosphorylation of [Akt] , but with divergent time courses and intensities , and survival was independent of Akt . Positive_regulation AKT1 EPHB2 11306698 804282 These results demonstrated that t-BHQ activated PI3-kinase and [Akt] , which was responsible for ARE mediated rGSTA2 induction , and that might negatively *regulate* rGSTA2 expression , whereas activation of p38 MAP kinase or of JNK by t-BHQ was not associated with the enzyme induction . Positive_regulation AKT1 EPHB2 11445578 850512 Finally , examination of the phosphorylation state of Akt after HGF stimulation revealed that inhibition *resulted* in a decrease in [Akt] activation at both 5 and 10 min . Positive_regulation AKT1 EPHB2 11454948 837876 Inhibition of [Akt] activation *required* almost complete inhibition of . Positive_regulation AKT1 EPHB2 12034359 948253 C ( 2 ) -ceramide induced a delayed activation of ( > 1 h ) and a much later *activation* of [Akt/PKB] ( > 3 h ) in human melanocytes . Positive_regulation AKT1 EPHB2 12138095 991541 Cell survival relied on two pertussis toxin-sensitive events , activation of and *activation* of phosphatidylinositol 3-kinase [(PI3K)/Akt] by S1P . Positive_regulation AKT1 EPHB2 12727858 1086459 In contrast , phosphorylation of [AKT] is *dependent* on and C-SRC activity . Positive_regulation AKT1 EPHB2 14996702 1257039 Surprisingly , phosphoinositide-3 (PI-3) kinase inhibitors block not only [PKB/Akt] activation but also *activation* of Raf and . Positive_regulation AKT1 EPHB2 15242975 1282057 when PI3K was inhibited , phosphorylation could be *induced* by microinjected activated [Akt] , indicating important cross-talk between the PI3K and ERK1/2 pathways . Positive_regulation AKT1 EPHB2 15344880 1292091 In these R- cells , PI3K inhibition by LY294002 enhanced insulin stimulation of phosphorylation whereas LY294002 *inhibited* insulin stimulation of [Akt] phosphorylation . Positive_regulation AKT1 EPHB2 15360086 1293607 The Hsp90 chaperone complex inhibitor , radicicol , potentiated heat induced cellular killing , and inhibition of p42/p44 and [Akt] *activation* rather than modification of Hsp expression might be involved in enhancing cellular thermosensitivity . Positive_regulation AKT1 EPHB2 15607817 1357032 Furthermore , U0126 and LY294002 , which respectively inhibit MEK *induced* phosphorylation and PI3 kinase mediated [Akt] phosphorylation had distinct effects on C3a induced responses . Positive_regulation AKT1 EPHB2 15767555 1384154 These events were associated with marked down-regulation of Raf-1 , MEK , and phosphorylation , diminished [Akt] *activation* , and enhanced phosphorylation of c-Jun NH2-terminal kinase (JNK) . Positive_regulation AKT1 EPHB2 15976193 1441140 Concurrent with p53 activation , DON activated two anti-apoptotic survival pathways as evidenced by both *dependent* p90 Rsk and [AKT] activation . Positive_regulation AKT1 EPHB2 16782756 1624997 Taken together , these data demonstrate that mtALDH overexpression attenuates hyperoxia induced cell death in lung epithelial cells through reduction of ROS , *activation* of , and [PI3K-Akt] cell survival signaling pathways . Positive_regulation AKT1 EPHB2 16877565 1638804 However , inhibitors of Raf-1 and MEK or a dominant negative mutant *blocked* FKN induced ERK , but not [Akt] and eNOS , phosphorylation . Positive_regulation AKT1 EPHB2 16954211 1633347 Under basal conditions , dopamine transporter knock-out mice show enhanced striatal DARPP-32 phosphorylation , *activation* of , and inactivation of [Akt] as compared with wild-type littermates . Positive_regulation AKT1 EPHB2 17433443 1736805 In cytokine producing Jurkat T cells , we have found that IL-4 induces activation of Erk and [Akt] , and the IL-4 induced STAT6 activity is *suppressed* by inhibitors of and PI3K . Positive_regulation AKT1 EPHB2 17540722 1778426 inhibitor PD98059 *inhibited* the PI3K activity , [Akt] phosphorylation , and lipid accumulation triggered by HG . Positive_regulation AKT1 EPHB2 17634416 1793043 These findings suggest that ouabain stimulated phosphorylation is *required* for [Akt] phosphorylation on Ser ( 473 ) , cell proliferation , and stimulation of Na ( + ) /K ( + ) -ATPase mediated ( 86 ) Rb uptake in OK cells . Positive_regulation AKT1 EPHB2 17804197 1810121 In this study , we demonstrate that Wnt5a specifically binds to Fzd3 in vitro and triggers phosphorylation of [Akt] *mediated* by phosphatidylinositol-3 kinase (PI3K) , but not that of or protein kinase C , in human primary cultured dermal fibroblasts . Positive_regulation AKT1 EPHB2 18224693 1884238 These results imply that cisplatin induced activation appears to mediate apoptotic cell death , but that constitutively activated [Akt1] and/or ERK pathway may *mediate* resistance to cisplatin in NSCLC cells . Positive_regulation AKT1 EPHB2 18310510 1904181 HG induces phosphoinositide 3- kinase [ PI3K ; inhibited by adenoviral ( Ad ) .dominant negative ( dn ) PI3Kp85 ] , Akt ( inhibited by Ad.dnAkt1 ) , and ( inhibited by PD-98059 ) activation and *induces* IL-17 expression via PI3K -- > [Akt] -- > ERK dependent signaling . Positive_regulation AKT1 EPHB2 18340449 1932014 Using chondrosarcoma cells stimulated with IL-1beta , the effects of GLN on the mRNA and protein levels of MMP-3 , the activation of JNK , , p38 , NF-kappaB , and AP-1 , the nuclear translocation of NF-kappaB/Rel family members , and [PI3-kinase/Akt] *activation* were studied . Positive_regulation AKT1 EPHB2 18509361 1971899 In a univariate analysis , shorter overall survival was associated with the presence of ulceration ( P=0.001 ) and BRAF exon 15 mutations ( P=0.005 ) as well as the absence of nuclear activation of [Akt] ( P=0.022 ) and of cytoplasmic *activation* of ( P=0.003 ) . Positive_regulation AKT1 EPHB2 19424594 2076404 Here , we showed that long-term ER stress resulted in inactivation of [Akt] and *activation* of in human hepatocellular carcinoma ( HCC ) cells . Positive_regulation AKT1 EPHB2 20177738 2272387 These observations indicate that Cbl-b promotes RBL-2H3 apoptosis induced by VP-16 or Ara-c , probably through inhibition of [Akt] and *activation* of . Positive_regulation AKT1 EPHB2 20668435 2317110 In addition , DHA caused [AKT] and ERK activation in a time dependent manner , and the DHA induced HO-1 upregulation could be *attenuated* by PI-3 kinase/AKT and inhibitors . Positive_regulation AKT1 EPHB2 21889928 2496509 In addition , lonidamine elicits and [Akt/mTOR] pathway *activation* , as indicated by increased ERK , Akt , p70S6K and rpS6 phosphorylation , and these effects are reduced by co-treatment with ATO . Positive_regulation AKT1 EPHB2 22039307 2508189 receptors *trigger* [Akt] activation and suppress Fas receptor induced apoptosis in malignant T lymphocytes . Positive_regulation AKT1 EPHB2 22964641 2827247 In defining each pathway 's contributions , we found that [AKT] inhibition alone maximally *induced* GAPDH nuclear accumulation , whereas inhibition alone had no effect on GAPDH localization . Positive_regulation AKT1 EPHB2 23087613 2690470 When analyzing possible signaling mechanisms we found that extracellular signal regulated kinase ( ERK ) and [Akt] are activated by C3 ( bot ) and is *induced* by the C3 ( E174Q ) mutant . Positive_regulation AKT1 EPHB2 23276632 2775373 Furthermore , E2 rapidly enhanced ERK and [Akt] activation in cortical neurons , and inhibitors of and Akt activation significantly *attenuated* E2 induction of excitatory glutamatergic synapses . Positive_regulation AKT1 EPHB2 23715867 2811532 a-Lipoic acid *enhanced* [Akt] phosphorylation and decreased ERK and JNK phosphorylation , whereas a-tocopherol enhanced and JNK phosphorylation but had little effect on Akt phosphorylation . Positive_regulation AKT1 EPHB2 24212072 2891951 Our results seem that inhibition of [Akt] and *activation* of or p38 MAPK may lead to the suppression of melanogenesis in eupafolin treated B16F10 mouse melanoma cells . Positive_regulation AKT1 EPHB2 24239652 2897701 Specifically , HA-induced NF-?B activation was mediated by ROS and [AKT] , and that HA-induced AP-1 activation was *mediated* by JNK and . Positive_regulation AKT1 EPHB2 24316039 2899361 We found that lifespan extension induced by cranberry was associated with reduced phosphorylation of , a component of oxidative stress response MAPK signaling , and slightly *increased* phosphorylation of [AKT] , a component of insulin-like signaling . Positive_regulation AKT1 EPHB2 24345501 2880894 TNF-a stimulated significantly phosphorylation on Ser536 of NF-?B/p65 , Ser473 of [Akt] at 5-15 min , and *activations* of IKK-ß and at 15-30 min. Diosgenin ( 1 µmol · Positive_regulation AKT1 EPHB2 24424889 2901248 Taken together , these findings suggest that MHY-449 induces apoptosis via downregulation of the [Akt/FoxO1] and *activation* of in androgen independent , p53-null and PTEN negative PC3 human prostate cancer cells . Positive_regulation AKT1 EPHB2 24530412 2924285 It is noteworthy that a tyrosine kinase receptor inhibitor , K252a , an inhibitor ( U0126 ) , and a PI3Kinase-Akt inhibitor ( LY294002 ) remarkably *attenuated* TrkB , ERK , and [Akt] phosphorylation as well as increase of OPN mRNA expression in the HCEM cells , respectively . Positive_regulation AKT1 EPHB2 24597762 2933799 Exposure of CGNs to GDF15 markedly induced the phosphorylation of ERK ( extracellular-signal regulated kinase ) , [Akt] and mTOR ( mammalian target of rapamycin ) , but the GDF15 induced IK densities and increased expression of Kv2.1 were *attenuated* only by Akt and mTOR , and not , inhibitors . Positive_regulation AKT1 EPHB2 24909280 2941801 in the LY294002 treatment group , the level of [p-AKT] protein decreased and *increased* ; Positive_regulation AKT1 F2R 19765562 2163531 In addition , [Akt] phosphorylation caused by plasmin was inhibited in the *presence* of inhibitor . Positive_regulation AKT1 F2R 24763028 2936957 It is concluded that thrombin can stimulate MSC proliferation by eliciting mediated [AKT] *activation* and subsequent up-regulation of c-MYC expression . Positive_regulation AKT1 FAS 14967838 1220243 signaling *induces* [Akt] activation and upregulation of endothelial nitric oxide synthase expression . Positive_regulation AKT1 FAS 14967838 1220255 Here , we report that engagement with Fas ligand *induced* activation of [Akt] and upregulation of endothelial nitric oxide synthase expression without induction of apoptosis . Positive_regulation AKT1 FAS 15665818 1369596 Additionally , [Akt] inhibition *induced* signaling was observed to link to the mitochondrial pathway via Bid cleavage . Positive_regulation AKT1 FAS 15806173 1417489 In contrast , inhibition of activity by the drug C75 *resulted* in downregulation of [phospho-AKT] and increased cell death . Positive_regulation AKT1 FAS 15806173 1417498 Furthermore , inhibition of activity by cerulenin or C75 *resulted* in downregulation of [phospho-AKT] , which preceded the induction of apoptosis . Positive_regulation AKT1 FAS 15982313 1424722 Using a variety of inhibitors and blocking antibodies , we demonstrated that : ( i ) apoptosis is required for the generation of the signal ( s ) leading to the activation of EGFR , ERK , and Akt; (ii) the activation of EGFR , ERK , and [Akt] by FasL is indeed *mediated* by its bona fide receptor ; Positive_regulation AKT1 FAS 19460632 2084804 omega3 also *restored* levels of cerebellar phospho ( p ) [-AKT] , phospho-extracellular regulated kinase ( p-ERK ) and phospho-c-Jun N-terminal kinase ( p-JNK ) , which were altered by hypothyroid insults , without interfering with the expression of TH responsive gene , myelin basic protein (mbp) . Positive_regulation AKT1 FAS 25086185 2956927 These data reveal a surprising sensitivity of K-Ras-driven cancer cells to suppression when stimulation of [Akt] and ERK was *prevented* . Positive_regulation AKT1 FGFBP1 17553847 1773829 At the molecular level , *enhanced* FGF2 induced protein tyrosine phosphorylation and [AKT/PKB] activation . Positive_regulation AKT1 FOXA1 22879989 2641675 An increase in IGFBP-3 , mediated by depletion of , *inhibited* phosphorylation of MAPK and [Akt] , and increased expression of the cell cycle regulators p21 and p27 . Positive_regulation AKT1 FOXO1 10358014 618636 These results suggest that may be a direct nuclear regulatory *target* for [Akt] in both metabolic and cell survival pathways . Positive_regulation AKT1 FOXO1 11237865 790428 We find that the overexpression of [ S256A ] ( where Ser-256 -- > Ala ) *blocks* [PKB] activity in cells , preventing phosphorylation of the endogenous substrates FKHRL1 and glycogen synthase kinase-3 . Positive_regulation AKT1 FOXO1 15256269 1272092 The present data demonstrate that activation of [PKB] is sufficient to mimic the effect of insulin on the expression of G6Pase and that *acts* as an activator of the G6Pase gene indicating that the established cellular models are suitable for the specific analysis of downstream targets of these signaling molecules . Positive_regulation AKT1 FOXO1 17303659 1725982 In contrast , increases p38 activity , and p38 is *required* for effects of Foxo1 on [PKB] , at least in part . Positive_regulation AKT1 FOXO1 18077353 1836689 Here , we report that sustained activation of either or FoxO3 in cardiac myocytes *increases* basal levels of [Akt] phosphorylation and kinase activity . Positive_regulation AKT1 FOXO1 18077353 1836696 *activated* [Akt] directly interacts with and phosphorylates FoxO , providing feedback inhibition . Positive_regulation AKT1 FOXO1 18077353 1836797 Repression of Akt-PP2A/B interactions and phosphatase activities contributes , at least in part , to *dependent* increases in [Akt] phosphorylation and kinase activity . Positive_regulation AKT1 FOXO1 18077353 1836833 Importantly , *mediated* increases in [Akt] activity diminish insulin signaling , as manifested by reduced Akt phosphorylation , reduced membrane translocation of Glut4 , and decreased insulin triggered glucose uptake . Positive_regulation AKT1 FOXO1 18249169 1865231 A new study by Ni et al. ( 2007 ) shows that sustained activation of or FoxO3 in cardiomyocytes selectively *enhances* the activity of [Akt/PKB] and reduces insulin signaling through inhibition of calcineurin and PP2A . Positive_regulation AKT1 FOXO1 20709952 2312823 However , whereas the [PI(3)K/Akt] regulation of Rag transcription is *mediated* by , we show in this study that the MEK/ERK pathway coordinates with the regulation of Rag by controlling the phosphorylation and turnover of E47 and its consequential binding to the Rag enhancer regions . Positive_regulation AKT1 FOXO1 22068162 2528239 The effect of progranulin on proliferation and [Akt] *activation* and subsequent effects of phosphorylation were assessed in vitro . Positive_regulation AKT1 FOXO1 24424889 2901240 Furthermore , MHY-449 reduced the phosphorylation of [Akt] and FoxO1 and *induced* the translocation of from cytoplasm to nucleus as shown by western blot analysis . Positive_regulation AKT1 FOXO1 24874427 2945692 *mediated* activation of [Akt] plays a critical role in vascular homeostasis . Positive_regulation AKT1 FOXO1 24874427 2945699 Moreover , *mediated* feedback activation of [Akt] maintains growth factor responsive Akt/mTORC1 activity within a homeostatic range . Positive_regulation AKT1 FUT4 20506505 2307948 These data suggested that not only *activates* MAPK and [PI3K/Akt] signals , but also promotes the crosstalk among these signaling pathways . Positive_regulation AKT1 FUT4 21337384 2411173 The results showed that overexpression *up-regulated* phosphorylation of ERK1/2 and [Akt] which was inhibited by CPA in dose dependent manner . Positive_regulation AKT1 FUT4 23887626 2821548 Moreover , *induced* activation of phosphatidylinositol 3-kinase [(PI3K)/Akt] , and inactivation of GSK3ß and nuclear translocation of NF-?B , resulting in increased Snail and MMP-9 expression and greater cell motility . Positive_regulation AKT1 GLP1R 22182839 2537188 Transgene expression restored *dependent* stimulation of cAMP and [Akt] phosphorylation in isolated islets , conferred GLP-1R dependent stimulation of ß cell proliferation , and was sufficient for restoration of GLP-1 stimulated insulin secretion in perifused islets . Positive_regulation AKT1 GLP1R 23900416 2839798 Hindbrain mediated suppression of food intake *requires* a PI3K dependent decrease in phosphorylation of membrane bound [Akt] . Positive_regulation AKT1 GLP1R 24269940 2893113 Finally , GW exerted anti-apoptotic effects via interfering with *dependent* [Akt/Bcl-2] and Bcl-xl/caspase-3 signaling pathways . Positive_regulation AKT1 GPR115 17329974 1706990 [Akt/TSC/mTOR] *activation* by the KSHV : emerging insights into the molecular oncogenesis and treatment of Kaposi 's sarcoma . Positive_regulation AKT1 GPR115 17949438 1825858 *induced* [Akt] activity in cellular proliferation and apoptosis . Positive_regulation AKT1 GPR132 17329974 1706979 [Akt/TSC/mTOR] *activation* by the KSHV : emerging insights into the molecular oncogenesis and treatment of Kaposi 's sarcoma . Positive_regulation AKT1 GPR132 17949438 1825847 *induced* [Akt] activity in cellular proliferation and apoptosis . Positive_regulation AKT1 GPR87 17329974 1707059 [Akt/TSC/mTOR] *activation* by the KSHV : emerging insights into the molecular oncogenesis and treatment of Kaposi 's sarcoma . Positive_regulation AKT1 GPR87 17949438 1825927 *induced* [Akt] activity in cellular proliferation and apoptosis . Positive_regulation AKT1 HBEGF 11882602 919640 PD98059 inhibited HB-EGF induced ERK activation , whereas it had no effect on [Akt] *activation* by . Positive_regulation AKT1 HBEGF 15380451 1298473 *induced* phosphorylation of ERK , p38 MAPK and [Akt] , which were suppressed by ZD1839 . Positive_regulation AKT1 HBEGF 15952178 1440639 The phosphatidylinositol 3'-kinase (PI3K) inhibitors LY294002 and wortmannin , and the MAPK/extracellular signal regulated kinase ( ERK ) kinase ( MEK ) inhibitors U0126 and PD98059 , reduced HB-EGF induced BrdU incorporation into cultures , and *enhanced* phosphorylation of [Akt] and ERK , implying a role for PI3K/Akt and MEK/ERK signaling in HB-EGF stimulated cell proliferation . Positive_regulation AKT1 HBEGF 16034135 1436427 In this report , we show that in intestinal epithelial cells , *triggered* PI3K dependent phosphorylation of [Akt] . Positive_regulation AKT1 HBEGF 16799022 1579190 On the other hand , AKT phosphorylation was much more sensitive to PP2 than ERK or EGFR phosphorylation because 3.13 microM PP2 effectively inhibited wound- or *induced* [AKT] phosphorylation . Positive_regulation AKT1 HBEGF 19470173 2091038 The induced clustering of EGFR was observed minimally after 5 min of integrin crosslinking but was more prominent after 15 min . EGFR clustering had minimal effect on the phosphorylation of [Akt] or Erk1 ,2 in response to EGF in suspended cells or in *response* to in adherent cells . Positive_regulation AKT1 HBEGF 19559571 2110519 Finally , the *induced* activation of [Akt] and eNOS was suppressed by VEGF competitive antagonist , CBO-P11 . Positive_regulation AKT1 HBEGF 21289053 2410022 However , general metalloprotease inhibition , as well as specific inhibitors of ( HB-EGF ) , *prevented* both EGFR and downstream [Akt] activation . Positive_regulation AKT1 HRH1 11959800 931435 *Stimulation* of [protein kinase B] and p70 S6 kinase by the in DDT1MF-2 smooth muscle cells . Positive_regulation AKT1 ID1 17855368 1818121 Furthermore , our results revealed that this effect was regulated by *induced* [Akt] activation through promoting the binding activity between Cav-1 and protein phosphatase 2A . Positive_regulation AKT1 ID1 19079342 2030880 *activates* [Akt] mediated Wnt signaling and p27 ( Kip1 ) phosphorylation through PTEN inhibition . Positive_regulation AKT1 IFI27 12768542 1094562 Second , ACTH-R triggers cAMP/PKA mediated antimitogenic mechanisms comprised of [Akt/PKB] dephosphorylation/deactivation , c-Myc protein degradation , and ( Kip1 ) protein *induction* . Positive_regulation AKT1 IFI27 19954644 2172451 Western blot results showed that the [Akt] phosphorylation and cyclin D1 expression was significantly decreased ( P < 0.01 ) , and the expression of ( KIP1 ) and p21 ( WAF1/CIPI ) *increased* . Positive_regulation AKT1 IL1B 11022128 738138 Furthermore , anti-inflammatory cytokines such as IL-4 and IL-10 that block IL-1b induced NFkappaB activation also attenuate *induced* [Akt] phosphorylation , despite the fact that IL-4 and IL-10 in isolation induced Akt phosphorylation . Positive_regulation AKT1 IL1B 11605009 871540 Pretreatment with SB203085 inhibited *induced* p38 and [AKT] phosphorylation . Positive_regulation AKT1 IL1B 11976320 953888 In human embryonic kidney 293 cells , *induces* IkappaB kinase beta (IKKbeta) activation , IkappaBalpha degradation , NF-kappaB transactivation , and weak [Akt] activation . Positive_regulation AKT1 IL1B 12126643 966020 P38 mitogen activated protein kinase (MAPK) was activated after 5min of IL-1beta treatment , whereas the extracellular signal regulated kinases , the c-jun amino-terminal kinases , and [protein kinase B/Akt] were not *activated* by . Positive_regulation AKT1 IL1B 12483539 1024810 Exogenous expression of either SHPS-1 mutants that lack SHP-2 binding function or a dominant negative mutant of SHP-2 markedly inhibited the *activation* of Erk 1/2 and [Akt] by , whereas wild type SHPS-1 did not . Positive_regulation AKT1 IL1B 12516562 1027881 *induced* phosphorylation of [PKB/Akt] depends on the presence of IRAK-1 . Positive_regulation AKT1 IL1B 12874320 1115029 A dominant negative mutant ( Mal-P/H ) of MyD88 adapter-like protein (Mal) , a protein with homology to MyD88 , failed to inhibit LPS- or *induced* [Akt] activity . Positive_regulation AKT1 IL1B 14612947 1163428 The PLC-PKC cascade is required for *dependent* Erk and [Akt] activation : their role in proliferation . Positive_regulation AKT1 IL1B 14612947 1163433 Pharmacological inhibition of the PLC-PKC cascade by using specific inhibitor for PLC-gamma ( U73122 ) and PKC ( GFX ) strongly inhibited *induced* Erk and [Akt] activation . Positive_regulation AKT1 IL1B 14612947 1163446 Taken together , our results suggest that a SHPS-1-PLC-gamma complex activate the PLC-PKC cascade , which is required for the activation of *dependent* Erk and [Akt] signalings and cell proliferation . Positive_regulation AKT1 IL1B 14764725 1207379 Antioxidant treatment of LPS stimulated neutrophils also inhibited the production of proinflammatory cytokines ( TNF-alpha , macrophage inflammatory protein-2 , and ) , as well as *activation* of the kinases IkappaB kinase alpha , IkappaB kinase beta , p38 , [Akt] , and extracellular receptor activated kinases 1 and 2 . Positive_regulation AKT1 IL1B 17291458 1710970 Curcumin inhibited the *induced* stimulation of up-stream protein kinase B [Akt] . Positive_regulation AKT1 IL1B 17299794 1718839 Src , PDGFR , and [PI3K/Akt] *mediated* the effects of because pretreatment with PP1 , AG1296 , and wortmannin also abrogated IL-1beta stimulated Src , PDGFR , and Akt phosphorylation , respectively . Positive_regulation AKT1 IL1B 17504920 1744645 In summary , results presented herein demonstrate that *stimulates* [PI3K/PKB-] , P70S6K- , and ERK1/2 dependent pathways in rat Sertoli cells . Positive_regulation AKT1 IL1B 17645739 1793263 Interestingly , Dex attenuated *mediated* activation of p38 MAPK and JNK , but not of [AKT] . Positive_regulation AKT1 IL1B 17920534 1804183 SA981 at a concentration of 100 microM partially inhibited *induced* phosphorylation of p38MAPK and [Akt] ( 12.0 % and 36.1 % inhibition of each total amount of phosphoprotein under IL-1beta coexistence condition , respectively ) . Positive_regulation AKT1 IL1B 20067833 2212259 These results indicated that glucose induced endogenous expression *increased* betaTC-6 cells apoptosis by inhibiting , at least in part , [IRS-2/Akt] mediated signalling through SOCS-1 upregulation . Positive_regulation AKT1 INPP4B 24288008 2926679 We further demonstrate that *regulates* [PI3K/Akt] signaling and exerts a tumor suppressor effect , impacting the proliferative , invasive , and tumorigenic capacity of melanoma cells . Positive_regulation AKT1 IRS4 10594015 654760 also *promoted* the activation of [PKB/Akt] and BAD phosphorylation during insulin stimulation ; Positive_regulation AKT1 IRS4 19029952 2029400 Once expressed , as well as binding to E1A and the insulin receptor , remains tyrosine phosphorylated and constitutively associates with the regulatory p85 subunit of phosphoinositide 3 kinase , *resulting* in the phosphorylation of [Akt] ( causing activation ) and GSK-3beta ( causing inhibition ) . Positive_regulation AKT1 ITGAL 18209096 1857847 CD28 ( - ) T cells , which are overrepresented in RA patients , have high cell surface expression and *induce* [Akt] phosphorylation in FLS more potently than their CD28 ( + ) counterparts . Positive_regulation AKT1 ITGB2 14960575 1227751 We have identified Vav , a guanine nucleotide exchange factor for Rac-1 , and PI3K/Akt , as regulators of the activation and inactivation phases of the activity of Rac-1 , respectively , in the context of LFA-1 signaling based on the following experimental evidence : ( i ) *induced* activation of Vav and [PI3K/Akt] with kinetics consistent with a regulatory role for these molecules on Rac-1 , ( ii ) overexpression of a constitutively active Vav mutant induces activation of Rac independently of LFA-1 stimulation whereas overexpression of a dominant negative Vav mutant blocks LFA-1 mediated Rac activation , ( iii ) pharmacological inhibition of PI3K/Akt prevented the fall in the activity of Rac-1 after its initial activation but had no effect on Vav activity , and ( iv ) overexpression of a dominant negative or a constitutively active Akt-1 induced or inhibited , respectively , Rac-1 activity . Positive_regulation AKT1 ITGB2 19630789 2112986 In microglia , fibrinogen mediates *activation* of [Akt] and Rho via the integrin receptor , while in neurons fibrinogen induces phosphorylation of epidermal growth factor (EGF) receptor via the alphavbeta3 integrin . Positive_regulation AKT1 LAMB3 22673183 2669800 Laminin-332 upregulation was also observed in CAFs and NBFs , but at a lower level than in InFs . *induced* [Akt] ( Ser473 ) phosphorylation by binding to integrin a3ß1 . Positive_regulation AKT1 MAOA 24865426 2945516 dependent activation of neuropilin-1 *promoted* [AKT/FOXO1/TWIST1] signaling , allowing FOXO1 binding at the TWIST1 promoter . Positive_regulation AKT1 MAP2K6 10331501 614630 However , neither two PI-3 kinase inhibitors , wortmannin and LY294002 , nor inhibitor PD98059 inhibited GM-CSF induced survival of eosinophils , although wortmannin and PD98059 *inhibited* GM-CSF induced [Akt] phosphorylation and MAP kinase activation in eosinophils , respectively . Positive_regulation AKT1 MAP2K6 10872812 707097 While the IGF-I induced activation of [PKB/Akt] was *inhibited* by PI3-K inhibitor LY294002 but not by inhibitor PD98059 , the activation of both MEK and ERK by IGF-I was inhibited by both . Positive_regulation AKT1 MAP2K6 10945642 721588 Phosphorylation of the cell survival promoting kinase Akt ( protein kinase B ) resulted from SF/HGF treatment of U373 cells , and both [Akt] phosphorylation and cell survival induced by SF/HGF were *inhibited* by phosphatidylinositol 3-kinase inhibitors but not by inhibitors of or protein kinase C. Cytoprotection by SF/HGF in vitro was also inhibited by transient expression of dominant negative Akt . Positive_regulation AKT1 MAP2K6 11454948 837884 Therefore , it is not clear whether inhibition of activation of [Akt] *resulted* from selective inhibition of or from additional actions on other unidentified common pathways . Positive_regulation AKT1 MAP2K6 11479233 842217 Inhibitors of ( U0126 ) and PI3K ( LY294002 ) *blocked* p42/p44 ( erk ) and [Akt] , respectively , and partially blocked HGF induced production of IL-8 and VEGF , whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A . Positive_regulation AKT1 MAP2K6 12114408 964041 Our results suggest the combination of paclitaxel and inhibitor *leads* to down-regulation of the [PI3K-Akt] signaling in addition to the proapoptotic effects of paclitaxel and MEK inhibitor alone . Positive_regulation AKT1 MAP2K6 12181443 977611 [Akt] activation induced by lysophosphatidic acid and sphingosine-1-phosphate *requires* both and p38 mitogen activated protein kinase and is cell-line specific . Positive_regulation AKT1 MAP2K6 12181443 977752 However , epidermal growth factor , thrombin , and endothelin-1 stimulated [Akt] S473 phosphorylation *require* p38 but not . Positive_regulation AKT1 MAP2K6 12411397 1010745 PE and ET-1 do not activate [protein kinase B] but stimulate Ras and Erk , and their ability to activate protein synthesis was *blocked* by inhibition of Ras or and by rapamycin , which inhibits mTOR ( mammalian target of rapamycin ) . Positive_regulation AKT1 MAP2K6 14719071 1197699 In cisplatin-resistant UM-SCC-23 in culture , which we have established , the protein levels of Ras , Raf-1 and were drastically elevated compared to parent UM-SCC-23 , and ERK and [Akt] signals were constitutively *activated* . Positive_regulation AKT1 MAP2K6 14993781 1216064 Furthermore , using Ad MEK DN , a dominant negative form of MEK , it was found that negatively *regulates* [Akt] phosphorylation upon IGF-1 stimulation . Positive_regulation AKT1 MAP2K6 15607817 1357038 Furthermore , U0126 and LY294002 , which respectively inhibit *induced* ERK phosphorylation and PI3 kinase mediated [Akt] phosphorylation had distinct effects on C3a induced responses . Positive_regulation AKT1 MAP2K6 15618457 1387739 The PI3K inhibitors wortmannin and LY-294002 and an [Akt] *inhibitor* , 1-L-6-hydroxymethyl-chiro-inositol 2- ( R ) -2-O-methyl-3-O-octadecylcarbonate , but not a inhibitor PD-98059 , blocked isoproterenol mediated eosinophil survival . Positive_regulation AKT1 MAP2K6 15767555 1384161 These events were associated with marked down-regulation of Raf-1 , , and ERK phosphorylation , diminished [Akt] *activation* , and enhanced phosphorylation of c-Jun NH2-terminal kinase (JNK) . Positive_regulation AKT1 MAP2K6 15801908 1432351 The ( MAPK/ERK kinase ) inhibitors PD98059 and U0126 blocked IGF-I stimulated ERK phosphorylation but did not *block* the phosphorylation of [Akt] and did not decrease proteoglycan synthesis . Positive_regulation AKT1 MAP2K6 16176063 1457719 The LPA induced phosphorylation of ERK 1/2 and CREB was blocked by inhibition of PI3K , PKC and , but that of [Akt] was only *inhibited* by wortmannin , the PI3K inhibitor . Positive_regulation AKT1 MAP2K6 16181409 1461911 The importance of these pathways was further confirmed by the activation of both ERK , in a *dependent* manner , and [Akt] , via PI3K . Positive_regulation AKT1 MAP2K6 16877565 1638810 However , inhibitors of Raf-1 and or a dominant negative ERK mutant *blocked* FKN induced ERK , but not [Akt] and eNOS , phosphorylation . Positive_regulation AKT1 MAP2K6 18224693 1884244 These results imply that cisplatin induced activation appears to mediate apoptotic cell death , but that constitutively activated [Akt1] and/or ERK pathway may *mediate* resistance to cisplatin in NSCLC cells . Positive_regulation AKT1 MAP2K6 18586026 1953384 These data show that TGF-beta induced NFkappaB activation is through mediated [AKT] *activation* , which is essential for TGF-beta to support of osteoclast survival . Positive_regulation AKT1 MAP2K6 18656513 1972862 was *required* for phosphorylation of ERK and CREB , but not [Akt] , whereas G ( 0 ) /G ( i ) -proteins were necessary for phosphorylation of Akt and CREB , and cGMP was necessary for Akt phosphorylation . Positive_regulation AKT1 MAP2K6 20542106 2301966 Activation of these pathways by ATP seemed to be independent , since LY294002 and U0126 , inhibitors of PI3K and , did not *block* the activation of ERK and [AKT] , respectively , although each compound blocked its respective target . Positive_regulation AKT1 MAP2K6 20668435 2317116 In addition , DHA caused [AKT] and ERK activation in a time dependent manner , and the DHA induced HO-1 upregulation could be *attenuated* by PI-3 kinase/AKT and inhibitors . Positive_regulation AKT1 MAP2K6 21557297 2464080 Pharmacologic inhibition of EGFR , , and PI3K kinase activity in SCC10A *reduced* phosphorylated levels of ERK-1/2 and [AKT] , production of MMP-9 and sE-cad , cell migration and invasion , and expressional changes of EMT markers ( E-cadherin and N-cadherin ) induced by EGF , indicating that EGFR activation promotes cell migration and invasion via ERK-1/2 and PI3K regulated MMP-9/E-cadherin signaling pathways . Positive_regulation AKT1 MAP2K6 22674052 2719212 Besides , expression of [phosphorylated-AKT] and phosphorylated-ERK1/2 in fluoxetine treated NSCs was effectively *blocked* ( P < 0.05 ) by both PI3-K inhibitor ( LY294002 ) and inhibitor ( PD98059 ) . Positive_regulation AKT1 MAP2K6 22964641 2827253 In defining each pathway 's contributions , we found that [AKT] inhibition alone maximally *induced* GAPDH nuclear accumulation , whereas inhibition alone had no effect on GAPDH localization . Positive_regulation AKT1 MAP2K6 23199222 2730618 Furthermore , specific PI3K inhibitors abrogated the phosphorylation of Erk1/2 , while inhibition of did not *prevent* the phosphorylation of [Akt] . Positive_regulation AKT1 MAP2K6 23817184 2815715 [Akt] was also activated under the basal conditions , and the activation was *suppressed* by a inhibitor and an ERK1/2 inhibitor . Positive_regulation AKT1 MAP2K6 24530412 2924291 It is noteworthy that a tyrosine kinase receptor inhibitor , K252a , an inhibitor ( U0126 ) , and a PI3Kinase-Akt inhibitor ( LY294002 ) remarkably *attenuated* TrkB , ERK , and [Akt] phosphorylation as well as increase of OPN mRNA expression in the HCEM cells , respectively . Positive_regulation AKT1 MAP2K6 24652289 2934694 Nearly all IRS1 Ser(P)/Thr ( P ) residues were stimulated by insulin and significantly suppressed by PI3K inhibition ; fewer were suppressed by [Akt] or mTOR inhibition , and none were *suppressed* by inhibition . Positive_regulation AKT1 MIP 24449419 2923098 Cadmium selectively *induces* and COX-2 through PTEN mediated [Akt] activation in RAW264.7 cells . Positive_regulation AKT1 NES 15896313 1407946 Thus , Akt1 contains a functional NES and mutation of the *results* in nuclear-predominant [Akt1] activation that is sufficient to induce migration . Positive_regulation AKT1 NGFR 22880054 2641715 Whereas Src kinases are often required for Syk activation , we show here that [PI3K/Akt] *activation* and autocrine IL-10 production by involves the Src family kinase Fyn . Positive_regulation AKT1 PECAM1 15632208 1387983 Sphingosine kinase-1 enhances endothelial cell survival through a *dependent* activation of [PI-3K/Akt] and regulation of Bcl-2 family members . Positive_regulation AKT1 PECAM1 16118242 1454344 *Role* of in the shear-stress induced activation of [Akt] and the endothelial nitric oxide synthase (eNOS) in endothelial cells . Positive_regulation AKT1 PECAM1 16118242 1454355 Down-regulation of using a siRNA approach *attenuated* the shear-stress induced phosphorylation of [Akt] and eNOS , as well as the shear-stress induced accumulation of cyclic GMP levels while the shear-stress induced phosphorylation of AMPK remained intact . Positive_regulation AKT1 PECAM1 19390054 2094935 Inward remodeling was associated with *dependent* NFkappaB activation , surface adhesion molecule expression , and leukocyte infiltration as well as [Akt] activation and vascular cell proliferation . Positive_regulation AKT1 PECAM1 23292117 2742028 EGCG inhibited HPV-16 oncoprotein induced angiogenesis conferred by NSCLC through the inhibition of HIF-1a protein expression and HIF-1a dependent expression of VEGF , IL-8 , and as well as *activation* of [Akt] , suggesting that HIF-1a may be a potential target of EGCG against HPV related NSCLC angiogenesis . Positive_regulation AKT1 PLAT 17498240 1739843 Consistent with neurotrophic effects , *activated* Raf-K/ERK , PKC and [PI3-K/Akt] , 5-60 min after treatment . Positive_regulation AKT1 PLAT 20440070 2268333 In contrast , induced delayed IPC required the proteolytic activity of tPA and was *mediated* by plasmin , the NMDA receptor , and [PKB] phosphorylation . Positive_regulation AKT1 PLAT 22162045 2549120 We found that *induces* a catalytic independent rapid and sustained activation of extracellular signal regulated kinase ( ERK ) 1/2 , Jun N-terminal kinase (JNK) , [Akt] , and p38 signaling pathways . Positive_regulation AKT1 PLAT 23280993 2758105 Furthermore , rADAMTS13 downregulated *induced* phosphorylation of [Akt] and activation of RhoA . Positive_regulation AKT1 PLAT 23562854 2777999 Glucose deprivation induced activation of [PI3K-Akt-GSK3ß] , p38 and AMPK , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation AKT1 PLAU 12545160 1051057 Downregulation of *inhibits* migration and [PI3k/Akt] signaling in glioblastoma cells . Positive_regulation AKT1 PLAU 15874933 1405688 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , [Akt] , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Positive_regulation AKT1 PRODH 22796327 2660076 The results provide evidence that is essential in proline protection against hydrogen peroxide mediated cell death and that proline/PRODH helps *activate* [Akt] in cancer cells . Positive_regulation AKT1 S1PR3 12385647 1034856 We previously demonstrated that sphingosine 1-phosphate (S1P) induced PLD activation via the G-protein coupled receptor endothelial differentiation gene (EDG) <3/S1P(3)> was *involved* in S1P induced stimulation of PI 3-kinase and [Akt] . Positive_regulation AKT1 S1PR3 14657000 1202004 mediated [Akt] *activation* and cross-talk with platelet derived growth factor receptor ( PDGFR ) . Positive_regulation AKT1 S1PR3 14657000 1202007 Using mouse embryonic fibroblasts ( MEFs ) from S1P receptor knockout mice , we show here that was *required* for S473 phosphorylation of [Akt] by S1P . Positive_regulation AKT1 S1PR3 15334188 1291016 Finally , S1P also protects endothelial cells from apoptosis through *activation* of phosphatidylinositol [3-kinase/Akt/eNOS] via S1P(1) and receptors . Positive_regulation AKT1 SCGB3A1 16266985 1478898 , an inhibitor of cell growth , invasion , and [AKT] *activation* . Positive_regulation AKT1 SLC38A3 11208554 787167 *induction* of [Akt] phosphorylation was inhibited by the phosphoinositide 3-kinase ( PI 3-kinase ) inhibitors LY-294002 ( 10 microM ) and wortmannin ( 200 nM ) but not by the mitogen activated protein kinase kinase 1 inhibitor PD-98059 ( 50 microM ) . Positive_regulation AKT1 SLC38A3 11208554 787172 The p38 kinase inhibitor SB-203580 inhibited *induction* of [Akt] phosphorylation and activation at a concentration ( 10 microM ) 10-fold higher than necessary to block p38 kinase ( 1 microM ) , suggesting the possible involvement of kinase activities other than p38 kinase . Positive_regulation AKT1 SLC38A3 15331357 1287936 *induction* of [Akt] activation was reduced by > 60 % by both dominant negative Ras and Rho and by 30 % by dominant negative Cdc42 . Positive_regulation AKT1 SLC38A3 15351698 1292590 D2 , a CCKB receptor antagonist , inhibited *induction* of [Akt] phosphorylation , measured by Western blots with anti-phospho-Akt antibodies . Positive_regulation AKT1 SLC38A3 15351698 1292593 The intracellular calcium chelator BAPTA-AM , but not the PKC inhibitor GF109203X , blocked *induction* of [Akt] . Positive_regulation AKT1 SLC38A3 15351698 1292597 In conclusion , *induces* [Akt] through activation of CCKB receptors and of intracellular calcium dependent , PKC independent , pathways . Positive_regulation AKT1 SLC38A3 23376640 2747985 In addition , knockdown of STAT3 expression significantly attenuated *induced* [PI3K/Akt] activation , COX-2 expression , and cell proliferation . Positive_regulation AKT1 SPHK1 14742298 1242754 S1P activated Akt and ERK within minutes , and inhibition of *blocked* RSV induced ERK and [Akt] activation , leading to accelerated cell death after viral infection . Positive_regulation AKT1 SPHK1 15210766 1262029 Blocking acid ceramidase but not activity in alveolar macrophages *led* to decreased ERK and [Akt] activity and induction of cell death . Positive_regulation AKT1 SPHK1 16164409 1456255 Notably , activation of the PI3K downstream mediator [PKB/Akt] by GPCR ligands *involves* the activity of and is independent of EGFR signal transactivation . Positive_regulation AKT1 SPHK1 17114809 1677154 Tumor necrosis factor-alpha stimulated cell proliferation is mediated through *dependent* [Akt] activation and cyclin D expression . Positive_regulation AKT1 SPHK1 17114809 1677176 In contrast , TNF-alpha stimulated [Akt] phosphorylation , which was also required for DNA synthesis , was *attenuated* by inhibition or SphK1 knockdown by small interfering RNA . Positive_regulation AKT1 SPHK1 17114809 1677196 We conclude that *dependent* [Akt] activation plays a significant role in TNF-alpha induced cyclin D expression and cell proliferation . Positive_regulation AKT1 SPHK1 21163859 2407758 Loss of *diminished* ASM mediated [AKT] phosphorylation , but exogenous S1P induced AKT activation in hepatocytes . Positive_regulation AKT1 SPHK1 21848514 2510100 However , inhibition did *diminish* EGF ( epidermal growth factor ) -driven increases in S1P levels and [Akt] ( also known as protein kinase B ) /ERK ( extracellular-signal regulated kinase ) phosphorylation . Positive_regulation AKT1 SPHK1 24572701 2919811 In vitro , the inhibition of induced cell death in colon cancer cell lines and *attenuated* the serum dependent [PI3K/Akt] signaling . Positive_regulation AKT1 STK39 9478990 487137 Furthermore , we show that deactivation of glycogen synthase kinase 3 and *activation* of rapamycin-sensitive by [PKB] in L6 myotubes might be involved in the enhancement of glycogen synthesis and protein synthesis , respectively . Positive_regulation AKT1 TGM2 18381937 1892944 *regulates* focal adhesion [kinase/AKT] activation by modulating PTEN expression in pancreatic cancer cells . Positive_regulation AKT1 TLR7 23979601 2850575 Both phosphatidylinositol 3-kinase [(PI3K)-Akt] and p38 mitogen activated protein kinase (MAPK) signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Positive_regulation AKT1 TLR7 23979601 2850936 These data describe a novel role for p38a-MK2/3 in regulating induced [Akt] *activation* in macrophages . Positive_regulation AKT1 TNF 10485710 644493 *activates* phosphatidylinositol-3-OH kinase ( PI(3)K ) and its downstream target [Akt] ( protein kinase B ) . Positive_regulation AKT1 TNF 10748004 690713 Here we report that both and IL-1 *activate* the anti-apoptotic protein kinase [Akt] in growth factor and serum deprived EC , assessed by Western blotting for phospho-Akt . Positive_regulation AKT1 TNF 11067939 747578 CPPD crystals were observed to *induce* a robust and transient activation of ERK1 , ERK2 , and [Akt] , whereas produced only a modest and delayed activation of Akt . Positive_regulation AKT1 TNF 11067939 747592 In the *presence* of , [Akt] activity was enhanced , and CPPD crystal induced activation of ERK1 and ERK2 was more sustained than with CPPD crystals alone , but TNF-alpha itself reduced the basal phosphotransferase activities of these MAP kinases . Positive_regulation AKT1 TNF 11247802 793338 The *activation* of phosphatidylinositol (PI) 3-kinase and [Akt/protein kinase B (PKB)] by and their roles on stimulation of protein synthesis were investigated in cultured neonatal rat cardiac myocytes . Positive_regulation AKT1 TNF 11247802 793347 *induced* marked activation of PI3-kinase and [Akt/PKB] , and the activation of PI3-kinase and Akt/PKB was rapid ( maximal at 10 and 15 min , respectively ) and concentration dependent . Positive_regulation AKT1 TNF 11247802 793355 [Akt/PKB] *activation* by was inhibited by a PI3-kinase-specific inhibitor LY-294002 and adenovirus mediated expression of a dominant negative mutant of PI3-kinase , indicating that TNF-alpha activates Akt/PKB through PI3-kinase activation . Positive_regulation AKT1 TNF 11356844 834412 *Activation* of phosphatidylinositol (PI) [3-kinase/Akt] signaling by activates IKK and NF-kappaB . Positive_regulation AKT1 TNF 11356844 834460 *activated* [Akt] in PC-3 cells , but not in DU145 cells , and the ability of TNF to activate NF-kappaB was blocked by pharmacological inhibition of PI 3-kinase activity in PC-3 cells , but not in DU145 cells . Positive_regulation AKT1 TNF 11418646 830253 *induced* activations of PI3K and [Akt] were inhibited by DMS . Positive_regulation AKT1 TNF 11423913 831041 These results suggest that *induced* MAP kinase and [PI3-kinase/Akt] signaling play important roles in protecting BAE cells from TNF cytotoxicity . Positive_regulation AKT1 TNF 11465707 839730 The levels of phosphorylated Akt and [Akt] kinase activity were increased by *stimulation* of primary RASF with ( 10 ng/ml ) . Positive_regulation AKT1 TNF 11563975 863076 Both and insulin-like growth factor 1 (IGF-1) *caused* a 6-10-fold wortmannin-sensitive increase in [protein kinase B (PKB)] activity within 5 min . Positive_regulation AKT1 TNF 11563975 863078 We conclude that , at physiological concentrations , *activates* endogenous [PKB] by stimulating PDK2 ( increase in Ser ( 473 ) phosphorylation ) in a PI3-kinase dependent ( wortmannin-sensitive ) manner , without causing detectable stimulation of PDK1 ( no increase in Thr ( 308 ) phosphorylation ) or ARNO translocation . Positive_regulation AKT1 TNF 12034358 948247 In SAS cells , *induced* the phosphorylation of [Akt] at both Ser473 and Thr308 , causing the activation of Akt , and also induced the phosphorylation and degradation of IkappaB ( inhibitor of NFkappaB ) . Positive_regulation AKT1 TNF 12052823 968762 Treatment with two pharmacological inhibitors of NF-kappa B , SN50 and N-tosyl-l-phenylalanine chloromethyl ketone ( TPCK ) , blocks *induced* [Akt] activation . Positive_regulation AKT1 TNF 12052823 968767 These results suggest that NF-kappa B is required for mediated [Akt] *activation* and that it lies upstream of the stimulation of Akt . Positive_regulation AKT1 TNF 12060576 952775 Strikingly , the *activation* of p42 ( mapk/erk2 ) and [Akt] by was also inhibited in the presence of NaCl . Positive_regulation AKT1 TNF 12086898 895221 PI3K inhibition significantly enhanced the antiproliferative and proapoptotic effects of TNF-alpha in both cell lines , Ly294002 also blocked *induced* [Akt] activation but failed to alter cytoplasmic IkappaBalpha degradation or subsequent NF-kappaB nuclear translocation . Positive_regulation AKT1 TNF 12483539 1024789 In addition , PP1 substantially inhibited the IL-2beta- and *dependent* activation of Erk 1/2 and [Akt] . Positive_regulation AKT1 TNF 12714600 1100550 Phosphorylation of [Akt] and the mammalian target of rapamycin ( but not extracellular regulated kinase or PKCzeta ) in *response* to was inhibited by aspirin treatment . Positive_regulation AKT1 TNF 12748063 1119604 Additionally , ethanol exposed cells display a blunting of *induced* [Akt] activation and Bcl-2 antagonist of cell death phosphorylation that may account , in part , for the increased sensitivity of the mitochondria to Bax mediated damage . Positive_regulation AKT1 TNF 14532277 1174868 Phosphorylation of VEGFR2 at Tyr-801 and Tyr-1175 , the critical sites for VEGF induced PI3K-Akt signaling , was not involved in mediated [Akt] *activation* . Positive_regulation AKT1 TNF 14532277 1174889 Furthermore , but not VEGF *induced* activation of VEGFR2 , [Akt] , and EC migration are blunted in EC genetically deficient with Etk . Positive_regulation AKT1 TNF 14532277 1174900 Taken together , our data demonstrated that induces transactivation between Etk and VEGFR2 , and Etk directly *activates* [PI3K-Akt] angiogenic signaling independent of VEGF induced VEGFR2-PI3K-Akt signaling pathway . Positive_regulation AKT1 TNF 14623898 1200887 Down-regulation of PTEN by NIK/NF-kappaB results in activation of the PI3K/Akt pathway and augmentation of *induced* [PI3K/Akt] stimulation . Positive_regulation AKT1 TNF 14630924 1201129 Furthermore , flavopiridol suppressed *induced* activation of [Akt] . Positive_regulation AKT1 TNF 14764725 1207378 Antioxidant treatment of LPS stimulated neutrophils also inhibited the production of proinflammatory cytokines ( , macrophage inflammatory protein-2 , and IL-1beta ) , as well as *activation* of the kinases IkappaB kinase alpha , IkappaB kinase beta , p38 , [Akt] , and extracellular receptor activated kinases 1 and 2 . Positive_regulation AKT1 TNF 15265936 1275718 Celecoxib also inhibited the *induced* interaction of [Akt] with I kappa B alpha kinase (IKK) . Positive_regulation AKT1 TNF 15358188 1293388 Western blot analyses revealed that [Akt] , which acts as a survival factor in cells , was activated in SMP30 , but not mock , transfectants either in the *presence* or absence of plus Act-D . Positive_regulation AKT1 TNF 15530848 1332708 In contrast , antioxidants did not prevent *induced* [Akt] and NF-kappaB activation . Positive_regulation AKT1 TNF 15646653 1349887 Stimulation of human neutrophils with granulocyte colony stimulating factor ( G-CSF ) , granulocyte-macrophage CSF (GM-CSF) , or *resulted* in phosphorylation of [Akt] , the potency being GM-CSF > G-CSF = TNF , which was inhibited by wortmannin . Positive_regulation AKT1 TNF 15710601 1395740 Evodiamine also inhibited *induced* [Akt] activation and its association with IKK . Positive_regulation AKT1 TNF 15746249 1403161 Collectively , our results suggest that *induces* the caspase dependent degradation of [Akt] via the cleavage and ubiquitination of Akt , which results in its degradation through the 26S proteasome . Positive_regulation AKT1 TNF 15792609 1386787 By stimulation of in AM-1 cells , the phosphorylation of [Akt] ( Ser473 ) and p44/42 mitogen activated protein kinase (MAPK) ( Thr202/Tyr204 ) was markedly *increased* in TNFalpha concentration and time dependent manner . Positive_regulation AKT1 TNF 15792609 1386816 Meanwhile , pretreatment with LY294002 , phosphatidylinositol-3-OH kinase (PI3K) inhibitor , could inhibit both *induced* phosphorylation of [Akt] ( Ser473 ) and p44/42 MAPK ( Thr202/Tyr204 ) . Positive_regulation AKT1 TNF 15793306 1387006 Methyl-beta-cyclodextrin did not alter total cell surface expression of TNFR1 or TNF induced degradation of IkappaBalpha , a measure of nuclear factor-kappaB activation , but it did inhibit *induced* phosphorylation of [Akt] , a measure of phosphatidylinositol-3 kinase activation . Positive_regulation AKT1 TNF 15808421 1391133 Similarly , DEM and CDNB inhibited *induced* [Akt] and eNOS phosphorylation , suggesting that thiol modification is involved in eNOS inductive pathways . Positive_regulation AKT1 TNF 15841081 1403985 However , gefitinib inhibited the *induced* activation of MAPKs and [Akt] . Positive_regulation AKT1 TNF 15953363 1421741 It inhibits *induced* PI3-kinase , [Akt] and NF-kappaB activation in these cells . Positive_regulation AKT1 TNF 16025396 1435604 *activated* the phosphorylation of p44/42 MAPK , p38 MAPK , SAPK/JNK and [Akt] in mesangial cells . Positive_regulation AKT1 TNF 16025396 1435620 PGE1 inhibited the *induced* phosphorylation of SAPK/JNK and [Akt] , but not p44/42 MAPK and p38 MAPK . Positive_regulation AKT1 TNF 16051251 1525210 Statin treatment of cells abrogated *induced* [Akt] phosphorylation and p65 nuclear translocation . Positive_regulation AKT1 TNF 16140562 1499246 These results suggested that TNFalpha induced both cell survival and apoptosis pathways in ameloblastoma and potential of TNFalpha in inducing apoptosis can be improved by inhibiting *induced* [Akt] and p44/42 mitogen activated protein kinase (MAPK) cell survival pathways . Positive_regulation AKT1 TNF 16230421 1470273 4-HPR also inhibited *induced* [Akt] activation linked with IKK activation . Positive_regulation AKT1 TNF 16269668 1502343 In human endothelial cells , we found that eNOS activation by is time dependent and *requires* activation of [Akt] , a known eNOS activator . Positive_regulation AKT1 TNF 16291729 1526063 *Activation* of MAPK and [Akt] by anti-HER2/neu inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation AKT1 TNF 16354764 1519358 Moreover , *induced* phosphorylation of [Akt] and extracellular signal regulated kinase ( ERK ) was blocked by glabridin treatment in HUVECs . Positive_regulation AKT1 TNF 16361577 1493166 However , *induced* [Akt] phosphorylation and IkappaB degradation were observed much less often in PC-9/ZD2001 cells than in PC-9 cells or PC-9/ZD2001R cells . Positive_regulation AKT1 TNF 16448212 1521715 PJ also abolished *induced* [AKT] activation , needed for NFkappaB activity . Positive_regulation AKT1 TNF 16458614 1534489 significantly *increased* extracellular signal related kinases ( ERK ) and [protein kinase B (PKB)] activation and , which was blocked by notoginsenoside R1 , PD098059 , U0126 or wortmannin . Positive_regulation AKT1 TNF 16794257 1631639 Quercetin also inhibited *induced* PI 3-kinase activity , [Akt] phosphorylation , intracellular H ( 2 ) O ( 2 ) production , NF-kappaB transactivation , IL-8 promoter activity , and steady-state mRNA levels , consistent with the notion that quercetin inhibits chemokine expression by attenuating NF-kappaB transactivation via a PI 3-kinase/Akt dependent pathway . Positive_regulation AKT1 TNF 16798728 1638518 Inhibition of Rac1 does not modulate *induced* ERK1/2 and [Akt] activation . Positive_regulation AKT1 TNF 16924232 1692171 Genetic deletion of PKR abrogates *induced* activation of IkappaBalpha kinase , JNK , [Akt] and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation . Positive_regulation AKT1 TNF 16924232 1692178 *induced* [Akt] activation needed for IKK activation was also abolished by deletion of PKR . Positive_regulation AKT1 TNF 16981137 1617030 *induced* the phosphorylation of [Akt] depending upon time . Positive_regulation AKT1 TNF 16981137 1617037 The phosphorylation of [Akt] *induced* by was markedly attenuated by LY294002 and wortmannin , inhibitors of PI3-kinase . Positive_regulation AKT1 TNF 16981137 1617041 PD98059 , a specific inhibitor of MEK , had little effect on the *induced* phosphorylation of [Akt] . Positive_regulation AKT1 TNF 17114809 1677177 In contrast , *stimulated* [Akt] phosphorylation , which was also required for DNA synthesis , was attenuated by SphK inhibition or SphK1 knockdown by small interfering RNA . Positive_regulation AKT1 TNF 17158207 1694184 Western blot analysis of L6 cell lysates demonstrated impaired insulin stimulated phosphorylation of [Akt] , serine/arginine-rich protein 40 , and glycogen synthase kinase 3beta in *response* to and the short chain C6 ceramide analog . Positive_regulation AKT1 TNF 17158602 1701116 In human tracheal smooth muscle cells , *induced* MMP-9 expression and [Akt] phosphorylation in a time dependent manner , which was attenuated by the inhibitors of Src ( PP1 ) , epidermal growth factor receptor ( AG1478 ) , PDGFR ( AG1296 ) , and PI3K ( LY294002 ) , respectively , revealed by reporter gene assay , RT-PCR , zymographic , and Western blot analyses . Positive_regulation AKT1 TNF 17158602 1701144 Thus , our study provides a new insight into the molecular mechanisms that *stimulated* [Akt] phosphorylation mediated through transactivation of Src and growth factor receptors may stimulate the recruitment of p300 , assemble transcription factor (p65) , and then lead to MMP-9 expression . Positive_regulation AKT1 TNF 17369858 1777760 Distinctive role of integrin mediated adhesion in *induced* [PKB/Akt] and NF-kappaB activation and endothelial cell survival . Positive_regulation AKT1 TNF 17369858 1777763 Here we report that integrin ligation acts permissive for *induced* [protein kinase B] ( PKB/Akt ) but not nuclear factor (NF)-kappaB activation . Positive_regulation AKT1 TNF 17369858 1777764 Taken together , these observations reveal a novel permissive role for integrins in *induced* [PKB/Akt] activation and prevention of TNF induced death distinct of NF-kappaB , and implicate the actin cytoskeleton in PKB/Akt mediated cell survival . Positive_regulation AKT1 TNF 17640567 1771201 Similarly , suppression of *induced* [AKT] activation by curcumin was also abrogated by glutathione . Positive_regulation AKT1 TNF 17971516 1859767 *induced* phosphorylation of [Akt] , and ERK1/2 was inhibited by an antibody against TNF-alpha receptor 1 (TNF-R1) . Positive_regulation AKT1 TNF 17971516 1859773 LY-294002 completely abolished *induced* stimulation of PS as well as phosphorylation of [Akt] and its downstream targets GSK-3 , p70 ( S6K ) , and 4E-BP1 . Positive_regulation AKT1 TNF 17994109 1851153 triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 MAPK , ERK 1/2 , SAPK/JNK and [Akt] activation , while increasing proliferation and migration . Positive_regulation AKT1 TNF 18091748 1847360 *induced* phosphorylation of extracellular signal regulated kinase ( ERK ) and [Akt] , but not p38 mitogen activated protein kinase (MAPK) , was attenuated by nicardipine , cilnidipine , benidipine , efonidipine , and azelnidipine . Positive_regulation AKT1 TNF 18180317 1856488 GLP-1 treatment also inhibited mediated *induction* of [Akt] phosphorylation . Positive_regulation AKT1 TNF 18227124 1895558 Moreover , *induced* [Akt] and CaM kinase II phosphorylation via cascades through Src/EGFR/PI3K and PLC/calcium/CaM , respectively . Positive_regulation AKT1 TNF 18273051 1931841 Here , we show that in normal keratinocytes and the transformed keratinocyte cell lines , HaCaT and A431 , *stimulates* [protein kinase B/Akt] , which results in activation of the survival complex mTORC1 ( mammalian target of rapamycin complex 1 ) and inhibition of the proapoptotic proteins Bad and FoxO3a . Positive_regulation AKT1 TNF 18287248 1896517 Flavopiridol suppresses *induced* activation of activator protein-1 , c-Jun N-terminal kinase , p38 mitogen activated protein kinase (MAPK) , p44/p42 MAPK , and [Akt] , inhibits expression of antiapoptotic gene products , and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells . Positive_regulation AKT1 TNF 18287248 1896536 It is noteworthy that this flavone also suppressed *induced* activation of [Akt] , a cell survival kinase , and expression of various antiapoptotic proteins , such as IAP-1 , IAP-2 , XIAP , Bcl-2 , Bcl-xL , and TRAF-1 . Positive_regulation AKT1 TNF 18490760 1917059 , in most cells examined , *activates* [Akt] to use IKKalpha to control mTOR activation . Positive_regulation AKT1 TNF 18490760 1917062 In MCF7 cells , does not *activate* [Akt] and requires IKKbeta to activate mTOR . Positive_regulation AKT1 TNF 18557926 1984194 We have recently shown that *induced* [Akt] activation may promote the early stages of skin cancer . Positive_regulation AKT1 TNF 18557926 1984198 In this work , we demonstrate that in the premalignant keratinocyte cell line HaCaT , *activates* [Akt] , ERK1/2 and p38 . Positive_regulation AKT1 TNF 18557926 1984202 The *dependent* phosphorylation of [Akt-ERK1/2] was slightly decreased by NF kappaB inhibition and in the presence of p38 blockers . Positive_regulation AKT1 TNF 18632801 1972582 also *caused* [PI3-kinase/Akt] activation , which was further increased by PDTC and prevented by the PI3-kinase inhibitor , LY294002 . Positive_regulation AKT1 TNF 19234337 2079526 However , *induced* [Akt] phosphorylation was blocked , and inhibiting Akt dramatically decreased CCL2 production . Positive_regulation AKT1 TNF 19275968 2072837 *stimulated* the phosphorylation levels of p38 MAPK , JNK , ERK1/2 and [Akt] in vascular endothelial cells . Positive_regulation AKT1 TNF 19404960 2075179 Inhibition of Mcl-1 by EGCG triggered caspase 3 activity in RA synovial fibroblasts , which was mediated via down-regulation of the *induced* [Akt] and NF-kappaB pathways . Positive_regulation AKT1 TNF 19760502 2264284 Moreover , *promoted* ErbB-2/ErbB-3 heterocomplex formation , [Akt] activation and NF-kappaB transcriptional activation . Positive_regulation AKT1 TNF 19879324 2197034 Rapamycin enhanced the IL-6 synthesis and the phosphorylation of [Akt] *induced* by also in human osteoblasts . Positive_regulation AKT1 TNF 20082310 2212576 *increased* the FAK , PI3K , and [Akt] phosphorylation . Positive_regulation AKT1 TNF 20135642 2235885 also *increased* the [Akt] and mTOR phosphorylation . Positive_regulation AKT1 TNF 20237236 2259888 *caused* activation of NF-kappaB , MAP kinases , and [PI3K-Akt] in podocytes , whereas blockade of these molecules did not affect inhibition of RAR by TNF-alpha . Positive_regulation AKT1 TNF 20333651 2266137 On the other hand , *stimulated* the phosphorylation of c-Src , EGFR , [Akt] , JNK1/2 , and c-Jun , which were inhibited by pretreatment with Gö6983 . Positive_regulation AKT1 TNF 20333651 2266150 We also showed that *induced* Akt translocation and the formation of an [Akt/p65/p300] complex . Positive_regulation AKT1 TNF 20562516 2290156 NAC also inhibited *induced* phosphorylation of [Akt] and NF-kappaB . Positive_regulation AKT1 TNF 20562516 2290163 W-7 and KN93 inhibited *induced* phosphorylation of [Akt] but not NF-kappaB . Positive_regulation AKT1 TNF 20730776 2323969 I/R *induced* early hepatic [protein kinase B] ( AKT ) phosphorylation in WT mice but not in Gas6 ( -/- ) mice without significant changes in c-Jun N-terminal kinase phosphorylation or nuclear factor kappa B translocation , whereas hepatic interleukin-1ß (IL-1ß) and messenger RNA levels were higher in Gas6 ( -/- ) mice versus WT mice . Positive_regulation AKT1 TNF 20732383 2363473 Wnt3a failed to affect the *induced* phosphorylation of p44/p42 MAP kinase , [Akt] , I?B or NF?B . Positive_regulation AKT1 TNF 20836895 2325629 LY294002 blocked *induced* phosphorylation of [Akt] and reduced the phosphorylation of both I?B-a and NF-?B . Positive_regulation AKT1 TNF 20937376 2375762 Three compounds all dose-dependently increased not only PPAR-? expression in EA.hy926 cells but inhibited *induced* phosphorylation of [Akt] , extracellular-signal regulated kinase ( ERK ) and protein kinase C ( PKC ) with different specificity . Positive_regulation AKT1 TNF 21040686 2339111 *activated* the [protein kinase B/Akt] and regulation of its downstream targets , mTOR , Bad and FoxO3a . Positive_regulation AKT1 TNF 21285293 2425710 Inhibitors of NADPH oxidase and/or p47phox siRNA diminished ROS production and COX-2 expression as well as phosphorylation of p38 mitogen activated protein kinase ( p38MAPK ) and [Akt] *mediated* either by AS serum or by . Positive_regulation AKT1 TNF 21300786 2403643 In addition to this effect , SubAB depressed basal and *induced* phosphorylation of [Akt] via the UPR . Positive_regulation AKT1 TNF 21344491 2415381 Consistently , treatment of HeLa cells with the compound significantly suppressed induced *activation* of [Akt] and phosphorylation of Ser536 in RelA/p65 , which is required for transactivation activity . Positive_regulation AKT1 TNF 21427355 2412168 In contrast to S6K1 , depletion of S6K2 by siRNA decreased basal and *induced* [Akt] phosphorylation . Positive_regulation AKT1 TNF 21545687 2554373 significantly *induced* phosphorylation of p38 MAPK , ERK , [Akt] and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation AKT1 TNF 21704193 2494337 3,4,5-Tricaffeoylquinic acid , Bay 11-7085 , Akt inhibitor and N-acetylcysteine inhibited the induced *activation* of NF-?B , activation of [Akt] , and formation of reactive oxygen and nitrogen species . Positive_regulation AKT1 TNF 21705614 2465726 Furthermore , luteolin inhibited *induced* phosphorylation of mitogen activated protein kinase/extracellular signal regulated kinase ( ERK ) kinase 1/ERK/p90 ( RSK ) , mitogen activated protein kinase kinase 4/c-Jun N-terminal kinase/c-Jun , and [Akt/p70] ( S6K ) . Positive_regulation AKT1 TNF 21856755 2473277 In addition , *induced* phosphorylation of extracellular signal regulated kinase , nuclear factor kappa B ( NF-?B ) and [Akt] in a time dependent manner , and increased nuclear translocation and promoter activity of NF-?B . Positive_regulation AKT1 TNF 21860594 2469241 Genipin dose- and time-dependently increased PPAR-? expression and inhibited *induced* phosphorylation of [Akt] and PKC with different degrees . Positive_regulation AKT1 TNF 22026410 2513647 Moreover , 1 abolished *induced* [Akt] phosphorylation . Positive_regulation AKT1 TNF 22433439 2588327 The use of inhibitors that block individual PI3K isoforms , including the novel selective PI3Kd inhibitor INK007 , showed that PI3Kd is required for PDGF- and *induced* [Akt] activation . Positive_regulation AKT1 TNF 22556157 2675439 LY294002 and wortmannin inhibited induced [Akt] *activation* , whereas only LY294002 inhibited CD38 expression . Positive_regulation AKT1 TNF 22561121 2608672 Zaprinast was found to activate ERK1/2 , p38 MAPK , JNK , NF?B , and [PI3K/Akt] , and subsequently , *induce* the mRNA expressions of IL-1a , IL-1ß , , CCL2 , CCL4 , CXCL1 , CXCL2 , and CD14 . Positive_regulation AKT1 TNF 22683933 2626479 Moreover , PA inhibited the *induced* phosphorylation of [AKT] , but not c-Jun N-terminal kinase , indicating that inhibition of survival signaling pathways activated by TNF-a may explain the effects of PA on TNF-a induced cytotoxicity . Positive_regulation AKT1 TNF 23243069 2757876 The inhibition of iTreg differentiation by TNF-a is mediated through a signaling cascade involving the induction of expression and the *activation* of [Akt] . Positive_regulation AKT1 TNF 23243069 2757879 Interestingly , this regulatory pathway is iTreg cell specific as does not *activate* [Akt] in naturally occurring regulatory T cells , therefore conferring a selective effect of TNF-a and its antagonism on iTreg cells . Positive_regulation AKT1 TNF 23328930 2798706 Immunofluorescence staining showed that alone *increased* the production of [P-Akt] , whereas LY294002 and 50 µM resveratrol suppressed the TNF-a stimulated expression of P-Akt . Positive_regulation AKT1 TNF 23333920 2758377 Interestingly , IL-27 promoted the basal and enhanced *induced* phosphorylation of p38 MAPK and [Akt] , but not I?Ba . Positive_regulation AKT1 TNF 23353699 2754232 In addition , *stimulated* [Akt] phosphorylation was inhibited by PP1 , AG1478 , AG1296 , or LY294002 . Positive_regulation AKT1 TNF 23427281 2887210 The *induces* eNOS and MMP-9 expression and [PKB] activation . Positive_regulation AKT1 TNF 23632129 2790727 LAR also enhanced *induced* phospho-p38 and [phospho-AKT] expression , but inhibited the expression of phospho-JNK and nuclear translocation of NF-?Bp65 in RA synovial fibroblasts . Positive_regulation AKT1 TNF 23699531 2792336 Recombinant PGRN or transfection of a cDNA encoding PGRN did not antagonize *dependent* NF?B , [Akt] , and Erk1/2 pathway activation ; Positive_regulation AKT1 TNF 23710745 2792800 also significantly *activated* the phosphorylation of PTEN , [AKT] and FOXO3a ( P < 0.05 ) . Positive_regulation AKT1 TNF 24151609 2859752 In our study , we found that a treatments *induce* MEK and [AKT] phosphorylation . Positive_regulation AKT1 TNF 24361597 2911237 *stimulated* [Akt] phosphorylation was inhibited by genistein , PP1 , AG1296 , LY294002 , or SH5 . Positive_regulation AKT1 TNF 24441870 2922925 We showed that markedly *stimulated* Jak2 , PDGFR , [Akt] , and p42/p44 MAPK phosphorylation , which were attenuated by their respective inhibitors . Positive_regulation AKT1 TNF 24441870 2922941 Moreover , *stimulated* [Akt] activation via a Jak2/PDGFR pathway in HPAEpiCs . Positive_regulation AKT1 TNF 24441870 2922980 On the other hand , could *induce* [Akt] and p42/p44 MAPK translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation AKT1 TNFSF10 11992615 938783 In addition , combined and wortmannin treatment *resulted* in cleavage of several proteins : PARP , [Akt] , p21/WAF1 , and MDM2 as well as dephosphorylation of Akt . Positive_regulation AKT1 TNFSF10 12668516 1085980 *activated* the protein kinase [Akt] in HUVECs , as assessed by Western blot for phospho-Akt . Positive_regulation AKT1 TNFSF10 12807432 1101892 rapidly ( from 20 min ) *induced* the phosphorylation of [Akt] and ERK , but not of c-Jun NH2-terminal kinase (JNK) . Positive_regulation AKT1 TNFSF10 15289937 1278541 Western blot analysis consistently showed that *induced* a significant activation of ERK1/2 , and a much weaker phosphorylation of [Akt] , while it did not affect the p38/MAPK pathway . Positive_regulation AKT1 TNFSF10 15711939 1373691 Conversely , *induced* caspase dependent cleavage of [Akt] neutralizing its anti-apoptotic effects . Positive_regulation AKT1 TNFSF10 17595512 1764777 *induced* the phosphorylation of ERK1/2 , but not of [Akt] . Positive_regulation AKT1 TNFSF10 19573813 2104762 Src *mediates* [AKT] regulation and cancer cell survival responses to CXCL12 and ( TRAIL ) , factors that are distinctively expressed in the bone metastasis microenvironment . Positive_regulation AKT1 TNFSF10 19861161 2184425 Data from gene knockdown experiments with an RNA interference ( RNAi ) technique show that c-Cbl is involved in the interaction between Src and PI3K p85 during TRAIL treatment , playing an important role in *induced* [Akt] phosphorylation . Positive_regulation AKT1 TNFSF10 20149311 2179051 Notably , CaMKII chemical inhibitor abrogated *induced* phosphorylation of [Akt] . Positive_regulation AKT1 TNFSF10 20400979 2273976 Ovarian cancer ascites protects from *induced* cell death through alphavbeta5 integrin mediated focal adhesion kinase and [Akt] activation . Positive_regulation AKT1 TNFSF10 21109947 2366260 Akt catalytic activation is known to increase during metabolic oxidative stress , but we show that also dramatically *induces* the catalytic activation of [Akt] in TRAIL-sensitive cells , but not in TRAIL-resistant cells . Positive_regulation AKT1 TNFSF10 21472268 2361571 Further investigation revealed that engagement *led* to the activation of [PI3K/Akt] as well as of NF-?B . Positive_regulation AKT1 TNFSF10 21472268 2361581 Our data demonstrated that the *activation* of [PI3K/Akt] and NF-?B by is responsible for resistance to TRAIL in human gastric cancer cells . Positive_regulation AKT1 TNFSF10 23408429 2759797 Mechanically , MTDH down-regulated caspase-8 , decreased caspase-8 recruitment into the TRAIL death inducing signaling complex , decreased caspase-3 and poly(ADP-ribose) polymerase-2 processing , increased Bcl-2 expression , and stimulated *induced* [Akt] phosphorylation , without altering death receptor status . Positive_regulation AKT1 TNFSF10 24308965 2904859 HSP27 phosphorylation modulates induced *activation* of [Src-Akt/ERK] signaling through interaction with ß-arrestin2 . Positive_regulation AKT1 TNFSF10 24308965 2904863 In addition , reduced HSP27 phosphorylation by KRIBB3 treatment or MK2 knockdown attenuated the induced *activation* of [Akt] and ERK survival signaling through suppressing the phosphorylation of Src . Positive_regulation AKT2 ANGPT1 10585289 571135 Ceramide induced endothelial cell death and abolished *mediated* activation of [Akt] and the effect on cell survival . Positive_regulation AKT2 ANGPT1 10625301 658524 *induced* phosphorylation of the serine-threonine kinase [Akt] at Ser473 in a PI 3'-kinase dependent manner . Positive_regulation AKT2 ANGPT1 12514118 1063780 Treatment of cells with the phosphatidyl-inositol 3-kinase (PI3-K) inhibitor , LY294002 , inhibited *induced* phosphorylation of [Akt] , restored the cleavage of the effector caspase-3 , and reduced the protective effect of Ang-1 against SD-induced toxicity . Positive_regulation AKT2 ANGPT1 16000309 1452800 These data suggested that *dependent* [Akt] phosphorylation through PI 3-kinase leads to the inhibition of JNK phosphorylation . Positive_regulation AKT2 ANGPT1 16679392 1612146 Pretreatment with either DPI or apocynin also significantly attenuated *induced* [Akt] and p44/42 MAPK phosphorylation . Positive_regulation AKT2 ANGPT1 16679392 1612162 Using mouse heart microvascular endothelial cells from wild-type ( WT ) mice and mice deficient in the p47(phox) component of NADPH oxidase ( p47 ( phox-/- ) ) , we found that although *stimulated* intracellular ROS , [Akt] and p42/44 MAPK phosphorylation , and cell migration in WT cells , the responses were strikingly suppressed in cells from the p47 ( phox-/- ) mice . Positive_regulation AKT2 ANGPT1 17965739 1831100 On the other hand , C-18 blocked activation of members of the mitogen activated protein kinase family and of the Ser/Thr kinase [Akt] *induced* by both VEGF and . Positive_regulation AKT2 ANGPT1 18556567 1946039 These alterations led to a significant impairment of *induced* [Akt] and eNOS phosphorylation , along with a remarkable impairment of Ang-1 induced endothelial cell migration and endothelial cell spheroid sprouting . Positive_regulation AKT2 ANGPT1 18565279 1929501 *induced* [Akt] phosphorylation , increased the Bcl-2/Bax ratio , and decreased the activation of caspase-9 and -3 . Positive_regulation AKT2 ANGPT1 19037734 2001601 ANG9-4 blocked mediated Tie2 phosphorylation and downstream [Akt] *activation* . Positive_regulation AKT2 ANGPT1 19615361 2124098 Treatment of HUVECs with the lipid raft disrupting agent methyl-beta-cyclodextrin selectively inhibited *induced* [Akt] phosphorylation , but not Erk1/2 phosphorylation . Positive_regulation AKT2 ANGPT1 20056911 2218424 A soluble form of Tie-2 produced in human umbilical vein endothelial cells was dramatically suppressed by treatment with siRNA-matrix metalloproteinase (MMP) 14 or tissue inhibitor of metalloproteinase 3 , resulting in an increase in cellular fTie-2 and thereby enhancing *dependent* [Akt] phosphorylation and Akt dependent endothelial functions , such as Ang-2 downregulation or an increase of endothelial viability . Positive_regulation AKT2 ANGPT1 20079751 2212516 Examination of downstream signaling revealed inhibition of *dependent* [Akt] phosphorylation . Positive_regulation AKT2 ANGPT1 20079751 2212521 Similar suppression of dependent *activation* of [Akt] by hyperglycemia was observed in large vessel human endothelial cells . Positive_regulation AKT2 ANGPT1 20079751 2212527 Incubation of microvascular endothelial cells with 200 microM palmitic acid significantly inhibited *dependent* [Akt] phosphorylation without affecting phosphorylation of the Tie-2 receptor or of ERK1/2 . Positive_regulation AKT2 ANGPT1 20519501 2289600 However , only *induces* Tie2 dependent [Akt] activation and subsequent survival signaling and endothelial quiescence . Positive_regulation AKT2 ARSA 20640495 2360387 Both SIM and DIP+low-dose *augmented* [Akt] phosphorylation and their effect was additive . Positive_regulation AKT2 BPI 17012258 1629180 , but not control protein thaumatin , *activated* extracellular regulated kinase (ERK) and [AKT] , and increased DNA synthesis in RPE and RPC but not in REC . Positive_regulation AKT2 BPI 18055828 1833396 The authors recently reported that can *induce* ERK1/2 and [Akt] activity and that it increases DNA synthesis in the bovine retinal pigment epithelial (RPE) and pericyte cells . Positive_regulation AKT2 BPI 18055828 1833401 Heparitinase , phosphatidylinositol-specific phospholipase C , and anti-GPC4 antibody suppressed *induced* ERK and [Akt] phosphorylation in bovine RPE . Positive_regulation AKT2 BPI 23740083 2807055 In addition , can inhibit angiogenesis , suppress LPS mediated platelet activation , increase DNA synthesis , and *activate* [ERK/Akt] signaling . Positive_regulation AKT2 C12orf75 22935015 2740237 binds with insulin receptor substrate 4 and *increases* insulin stimulated [phospho-Akt] and regulates AMP activated protein kinase and mammalian target of rapamycin downstream target S6 kinase phosphorylation . Positive_regulation AKT2 CAPN8 23071514 2685957 Pro-death activity of violacein is actually carried out by inhibition of and DAPK1 and *activation* of PKA , [AKT] and PDK , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation AKT2 CAPN8 23455548 2781774 Blocking AKT further increased doxorubicin induced cardiac injuries , suggesting the effects of inhibition may be *mediated* by inactivating the [AKT] signalling . Positive_regulation AKT2 CAPN8 23467348 2750073 BDNF treatment increased phosphorylation of both Akt and ERK , but only the effect on [Akt] was *blocked* by inhibition . Positive_regulation AKT2 CCND1 19114984 2031796 PTK/ZK also induced cell cycle arrest , accompanied by increasing the expression of p27 ( Kip1 ) and downregulation of and cyclin E. PTK/ZK significantly *inhibited* vascular endothelial growth factor ( VEGF ) expression , as well as VEGF simulated cell proliferation and phosphorylation of [Akt] in activated HSCs . Positive_regulation AKT2 CCND1 19935697 2210094 The expression of *required* both EGFR mediated ERK and [AKT] activation . Positive_regulation AKT2 CCND1 22579115 2609551 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated and Cyclin B1 proteins as well as *activation* of [PI3K/Akt] and Raf/MEK/ERK , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation AKT2 CCND1 24737397 2943104 Mechanistically , aberrant PRL-3 expression promoted cell cycle progression and enhanced the antiapoptotic machinery of AML cells to drug cytotoxicity through downregulation of p21 and upregulation of and CDK2 and *activation* of STAT5 and [AKT] . Positive_regulation AKT2 CD14 22561121 2608678 Zaprinast was found to activate ERK1/2 , p38 MAPK , JNK , NF?B , and [PI3K/Akt] , and subsequently , *induce* the mRNA expressions of IL-1a , IL-1ß , TNF-a , CCL2 , CCL4 , CXCL1 , CXCL2 , and . Positive_regulation AKT2 CEACAM6 18159236 1838555 The colonocyte surface level of integrin alpha5 and the activation of [AKT] *increased* progressively with the expression levels of . Positive_regulation AKT2 CEACAM6 18614350 1947297 Suppression of expression using small interfering RNA ( siRNA ) completely reversed migration and invasion of MCF-7 : 5C and MCF-7 : 2A cells and it significantly *reduced* phosphorylated [Akt] and c-Src expression in these cells . Positive_regulation AKT2 CHI3L1 23972995 2836233 We also demonstrate that *activates* macrophage mitogen activated protein kinase , protein kinase [B/AKT] , and Wnt/ß-catenin signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation AKT2 CLU 21270507 2387620 The protective effect of clusterin on H2O2 induced apoptosis is impaired by PI3K inhibitor LY294002 , which effectively suppresses *induced* activation of [Akt] and GSK-3ß . Positive_regulation AKT2 CLU 22012253 2498763 Secreted , which is selectively increased after transformation , *activates* the survival factor [AKT] , whereas intracellular CLU inhibits the activity of the oncogenic transcription factor nuclear factor kappa B . Positive_regulation AKT2 CLU 24569077 2924723 The phosphorylation of [Akt] *induced* by was blocked by pretreatment with gallein or LY294002 but not with U73122 , indicating that Gß? released from the PTX-sensitive Gi protein complex activated PLC and PI3K/Akt signaling pathways separately . Positive_regulation AKT2 CTGF 16408113 1513471 *enhanced* the mRNA expression and protein release of fractalkine , MCP-1 , and RANTES , the expression of phospho ( P ) -p42/44 mitogen activated protein kinase (MAPK) , P-phosphoinositide 3-kinase (PI3-K) , [P-Akt] , and activity of nuclear factor-kappaB (NF-kappaB) in mesangial cells . Positive_regulation AKT2 CTGF 16408113 1513530 P-PI3-K blockade downregulated the *stimulated* expression of P-PI3-K , [P-Akt] , and NF-kappaB but not P-p42/44 MAPK , and partially decreased the release of the above chemokines . Positive_regulation AKT2 CTGF 16408113 1513539 LXA ( 4 ) dose-dependently inhibited the *stimulated* mRNA expression and protein release of the above chemokines , and the expression of P-p42/44MAPK , P-PI3-K , [P-Akt] , and NF-kappaB . Positive_regulation AKT2 CTGF 16877704 1600903 Most interestingly , overexpression of *suppressed* insulin-like growth factor-I dependent [Akt] phosphorylation and epidermal growth factor dependent extracellular signal regulated kinase 1/2 phosphorylation . Positive_regulation AKT2 CTGF 18375200 1899008 *induces* cardiac hypertrophy through [Akt] signaling . Positive_regulation AKT2 CTGF 20213804 2249221 *induced* phosphorylation of p38 , ERK-1/2 , JNK , and [Akt] , but not Smad3 , in transgenic mouse fibroblasts compared with wild-type mouse fibroblasts . Positive_regulation AKT2 CTGF 22363445 2561521 induced PDGF-B expression in endothelial cells , and *potentiated* PDGF-B mediated [Akt] signaling in mural ( vascular smooth muscle/pericyte ) cells . Positive_regulation AKT2 CTGF 23208610 2745465 Concentration-effect experiments revealed CCN2 stimulated phosphorylation of Akt ( Ser473 ) and downstream GSK-3ß ( Ser9 ) with EC50 ~250 nmol/L. *stimulated* phosphorylation of [Akt] and GSK-3ß was sensitive to inhibition of PI3-kinase ( LY294002 ) . Positive_regulation AKT2 DAPK1 23071514 2685961 Pro-death activity of violacein is actually carried out by inhibition of calpain and and *activation* of PKA , [AKT] and PDK , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation AKT2 EDN2 15860794 1425747 Both MBP1 and *induced* phosphorylation of [Akt] , but with divergent time courses and intensities , and survival was independent of Akt . Positive_regulation AKT2 EPHB2 11306698 804283 These results demonstrated that t-BHQ activated PI3-kinase and [Akt] , which was responsible for ARE mediated rGSTA2 induction , and that might negatively *regulate* rGSTA2 expression , whereas activation of p38 MAP kinase or of JNK by t-BHQ was not associated with the enzyme induction . Positive_regulation AKT2 EPHB2 11445578 850513 Finally , examination of the phosphorylation state of Akt after HGF stimulation revealed that inhibition *resulted* in a decrease in [Akt] activation at both 5 and 10 min . Positive_regulation AKT2 EPHB2 11454948 837877 Inhibition of [Akt] activation *required* almost complete inhibition of . Positive_regulation AKT2 EPHB2 12034359 948254 C ( 2 ) -ceramide induced a delayed activation of ( > 1 h ) and a much later *activation* of [Akt/PKB] ( > 3 h ) in human melanocytes . Positive_regulation AKT2 EPHB2 12138095 991543 Cell survival relied on two pertussis toxin-sensitive events , activation of and *activation* of phosphatidylinositol 3-kinase [(PI3K)/Akt] by S1P . Positive_regulation AKT2 EPHB2 12727858 1086461 In contrast , phosphorylation of [AKT] is *dependent* on and C-SRC activity . Positive_regulation AKT2 EPHB2 14996702 1257041 Surprisingly , phosphoinositide-3 (PI-3) kinase inhibitors block not only [PKB/Akt] activation but also *activation* of Raf and . Positive_regulation AKT2 EPHB2 15242975 1282058 when PI3K was inhibited , phosphorylation could be *induced* by microinjected activated [Akt] , indicating important cross-talk between the PI3K and ERK1/2 pathways . Positive_regulation AKT2 EPHB2 15344880 1292094 In these R- cells , PI3K inhibition by LY294002 enhanced insulin stimulation of phosphorylation whereas LY294002 *inhibited* insulin stimulation of [Akt] phosphorylation . Positive_regulation AKT2 EPHB2 15360086 1293608 The Hsp90 chaperone complex inhibitor , radicicol , potentiated heat induced cellular killing , and inhibition of p42/p44 and [Akt] *activation* rather than modification of Hsp expression might be involved in enhancing cellular thermosensitivity . Positive_regulation AKT2 EPHB2 15607817 1357040 Furthermore , U0126 and LY294002 , which respectively inhibit MEK *induced* phosphorylation and PI3 kinase mediated [Akt] phosphorylation had distinct effects on C3a induced responses . Positive_regulation AKT2 EPHB2 15767555 1384164 These events were associated with marked down-regulation of Raf-1 , MEK , and phosphorylation , diminished [Akt] *activation* , and enhanced phosphorylation of c-Jun NH2-terminal kinase (JNK) . Positive_regulation AKT2 EPHB2 15976193 1441141 Concurrent with p53 activation , DON activated two anti-apoptotic survival pathways as evidenced by both dependent p90 Rsk and [AKT] *activation* . Positive_regulation AKT2 EPHB2 16782756 1625011 Taken together , these data demonstrate that mtALDH overexpression attenuates hyperoxia induced cell death in lung epithelial cells through reduction of ROS , *activation* of , and [PI3K-Akt] cell survival signaling pathways . Positive_regulation AKT2 EPHB2 16877565 1638813 However , inhibitors of Raf-1 and MEK or a dominant negative mutant *blocked* FKN induced ERK , but not [Akt] and eNOS , phosphorylation . Positive_regulation AKT2 EPHB2 16954211 1633348 Under basal conditions , dopamine transporter knock-out mice show enhanced striatal DARPP-32 phosphorylation , *activation* of , and inactivation of [Akt] as compared with wild-type littermates . Positive_regulation AKT2 EPHB2 17433443 1736809 In cytokine producing Jurkat T cells , we have found that IL-4 induces activation of Erk and [Akt] , and the IL-4 induced STAT6 activity is *suppressed* by inhibitors of and PI3K . Positive_regulation AKT2 EPHB2 17540722 1778440 inhibitor PD98059 *inhibited* the PI3K activity , [Akt] phosphorylation , and lipid accumulation triggered by HG . Positive_regulation AKT2 EPHB2 17634416 1793044 These findings suggest that ouabain stimulated phosphorylation is *required* for [Akt] phosphorylation on Ser ( 473 ) , cell proliferation , and stimulation of Na ( + ) /K ( + ) -ATPase mediated ( 86 ) Rb uptake in OK cells . Positive_regulation AKT2 EPHB2 17804197 1810124 In this study , we demonstrate that Wnt5a specifically binds to Fzd3 in vitro and triggers phosphorylation of [Akt] *mediated* by phosphatidylinositol-3 kinase (PI3K) , but not that of or protein kinase C , in human primary cultured dermal fibroblasts . Positive_regulation AKT2 EPHB2 18310510 1904183 HG induces phosphoinositide 3- kinase [ PI3K ; inhibited by adenoviral ( Ad ) .dominant negative ( dn ) PI3Kp85 ] , Akt ( inhibited by Ad.dnAkt1 ) , and ( inhibited by PD-98059 ) activation and *induces* IL-17 expression via PI3K -- > [Akt] -- > ERK dependent signaling . Positive_regulation AKT2 EPHB2 18340449 1932019 Using chondrosarcoma cells stimulated with IL-1beta , the effects of GLN on the mRNA and protein levels of MMP-3 , the *activation* of JNK , , p38 , NF-kappaB , and AP-1 , the nuclear translocation of NF-kappaB/Rel family members , and [PI3-kinase/Akt] activation were studied . Positive_regulation AKT2 EPHB2 18509361 1971900 In a univariate analysis , shorter overall survival was associated with the presence of ulceration ( P=0.001 ) and BRAF exon 15 mutations ( P=0.005 ) as well as the absence of nuclear activation of [Akt] ( P=0.022 ) and of cytoplasmic *activation* of ( P=0.003 ) . Positive_regulation AKT2 EPHB2 19424594 2076405 Here , we showed that long-term ER stress resulted in inactivation of [Akt] and *activation* of in human hepatocellular carcinoma ( HCC ) cells . Positive_regulation AKT2 EPHB2 20177738 2272388 These observations indicate that Cbl-b promotes RBL-2H3 apoptosis induced by VP-16 or Ara-c , probably through inhibition of [Akt] and *activation* of . Positive_regulation AKT2 EPHB2 20668435 2317118 In addition , DHA caused [AKT] and ERK activation in a time dependent manner , and the DHA induced HO-1 upregulation could be *attenuated* by PI-3 kinase/AKT and inhibitors . Positive_regulation AKT2 EPHB2 21889928 2496510 In addition , lonidamine elicits and [Akt/mTOR] pathway *activation* , as indicated by increased ERK , Akt , p70S6K and rpS6 phosphorylation , and these effects are reduced by co-treatment with ATO . Positive_regulation AKT2 EPHB2 22039307 2508194 receptors *trigger* [Akt] activation and suppress Fas receptor induced apoptosis in malignant T lymphocytes . Positive_regulation AKT2 EPHB2 22964641 2827255 In defining each pathway 's contributions , we found that [AKT] inhibition alone maximally *induced* GAPDH nuclear accumulation , whereas inhibition alone had no effect on GAPDH localization . Positive_regulation AKT2 EPHB2 23087613 2690471 When analyzing possible signaling mechanisms we found that extracellular signal regulated kinase ( ERK ) and [Akt] are activated by C3 ( bot ) and is *induced* by the C3 ( E174Q ) mutant . Positive_regulation AKT2 EPHB2 23276632 2775374 Furthermore , E2 rapidly enhanced ERK and [Akt] activation in cortical neurons , and inhibitors of and Akt activation significantly *attenuated* E2 induction of excitatory glutamatergic synapses . Positive_regulation AKT2 EPHB2 23715867 2811533 a-Lipoic acid *enhanced* [Akt] phosphorylation and decreased ERK and JNK phosphorylation , whereas a-tocopherol enhanced and JNK phosphorylation but had little effect on Akt phosphorylation . Positive_regulation AKT2 EPHB2 24212072 2891965 Our results seem that inhibition of [Akt] and *activation* of or p38 MAPK may lead to the suppression of melanogenesis in eupafolin treated B16F10 mouse melanoma cells . Positive_regulation AKT2 EPHB2 24239652 2897702 Specifically , HA-induced NF-?B activation was mediated by ROS and [AKT] , and that HA-induced AP-1 activation was *mediated* by JNK and . Positive_regulation AKT2 EPHB2 24316039 2899362 We found that lifespan extension induced by cranberry was associated with reduced phosphorylation of , a component of oxidative stress response MAPK signaling , and slightly *increased* phosphorylation of [AKT] , a component of insulin-like signaling . Positive_regulation AKT2 EPHB2 24345501 2880898 TNF-a stimulated significantly phosphorylation on Ser536 of NF-?B/p65 , Ser473 of [Akt] at 5-15 min , and *activations* of IKK-ß and at 15-30 min. Diosgenin ( 1 µmol · Positive_regulation AKT2 EPHB2 24424889 2901249 Taken together , these findings suggest that MHY-449 induces apoptosis via downregulation of the [Akt/FoxO1] and *activation* of in androgen independent , p53-null and PTEN negative PC3 human prostate cancer cells . Positive_regulation AKT2 EPHB2 24530412 2924295 It is noteworthy that a tyrosine kinase receptor inhibitor , K252a , an inhibitor ( U0126 ) , and a PI3Kinase-Akt inhibitor ( LY294002 ) remarkably *attenuated* TrkB , ERK , and [Akt] phosphorylation as well as increase of OPN mRNA expression in the HCEM cells , respectively . Positive_regulation AKT2 EPHB2 24597762 2933801 Exposure of CGNs to GDF15 markedly induced the phosphorylation of ERK ( extracellular-signal regulated kinase ) , [Akt] and mTOR ( mammalian target of rapamycin ) , but the GDF15 induced IK densities and increased expression of Kv2.1 were *attenuated* only by Akt and mTOR , and not , inhibitors . Positive_regulation AKT2 EPHB2 24909280 2941802 in the LY294002 treatment group , the level of [p-AKT] protein decreased and *increased* ; Positive_regulation AKT2 F2R 19765562 2163532 In addition , [Akt] phosphorylation caused by plasmin was inhibited in the *presence* of inhibitor . Positive_regulation AKT2 F2R 24763028 2936958 It is concluded that thrombin can stimulate MSC proliferation by eliciting mediated [AKT] *activation* and subsequent up-regulation of c-MYC expression . Positive_regulation AKT2 FAS 14967838 1220244 signaling *induces* [Akt] activation and upregulation of endothelial nitric oxide synthase expression . Positive_regulation AKT2 FAS 14967838 1220256 Here , we report that engagement with Fas ligand *induced* activation of [Akt] and upregulation of endothelial nitric oxide synthase expression without induction of apoptosis . Positive_regulation AKT2 FAS 15665818 1369597 Additionally , [Akt] inhibition *induced* signaling was observed to link to the mitochondrial pathway via Bid cleavage . Positive_regulation AKT2 FAS 15806173 1417490 In contrast , inhibition of activity by the drug C75 *resulted* in downregulation of [phospho-AKT] and increased cell death . Positive_regulation AKT2 FAS 15806173 1417499 Furthermore , inhibition of activity by cerulenin or C75 *resulted* in downregulation of [phospho-AKT] , which preceded the induction of apoptosis . Positive_regulation AKT2 FAS 15982313 1424723 Using a variety of inhibitors and blocking antibodies , we demonstrated that : ( i ) apoptosis is required for the generation of the signal ( s ) leading to the activation of EGFR , ERK , and Akt; (ii) the activation of EGFR , ERK , and [Akt] by FasL is indeed *mediated* by its bona fide receptor ; Positive_regulation AKT2 FAS 19460632 2084805 omega3 also *restored* levels of cerebellar phospho ( p ) [-AKT] , phospho-extracellular regulated kinase ( p-ERK ) and phospho-c-Jun N-terminal kinase ( p-JNK ) , which were altered by hypothyroid insults , without interfering with the expression of TH responsive gene , myelin basic protein (mbp) . Positive_regulation AKT2 FAS 25086185 2956928 These data reveal a surprising sensitivity of K-Ras-driven cancer cells to suppression when stimulation of [Akt] and ERK was *prevented* . Positive_regulation AKT2 FGFBP1 17553847 1773831 At the molecular level , *enhanced* FGF2 induced protein tyrosine phosphorylation and [AKT/PKB] activation . Positive_regulation AKT2 FOXA1 22879989 2641676 An increase in IGFBP-3 , mediated by depletion of , *inhibited* phosphorylation of MAPK and [Akt] , and increased expression of the cell cycle regulators p21 and p27 . Positive_regulation AKT2 FOXO1 10358014 618637 These results suggest that may be a direct nuclear regulatory *target* for [Akt] in both metabolic and cell survival pathways . Positive_regulation AKT2 FOXO1 18077353 1836691 Here , we report that sustained activation of either or FoxO3 in cardiac myocytes *increases* basal levels of [Akt] phosphorylation and kinase activity . Positive_regulation AKT2 FOXO1 18077353 1836700 *activated* [Akt] directly interacts with and phosphorylates FoxO , providing feedback inhibition . Positive_regulation AKT2 FOXO1 18077353 1836801 Repression of Akt-PP2A/B interactions and phosphatase activities contributes , at least in part , to *dependent* increases in [Akt] phosphorylation and kinase activity . Positive_regulation AKT2 FOXO1 18077353 1836837 Importantly , *mediated* increases in [Akt] activity diminish insulin signaling , as manifested by reduced Akt phosphorylation , reduced membrane translocation of Glut4 , and decreased insulin triggered glucose uptake . Positive_regulation AKT2 FOXO1 18249169 1865233 A new study by Ni et al. ( 2007 ) shows that sustained activation of or FoxO3 in cardiomyocytes selectively *enhances* the activity of [Akt/PKB] and reduces insulin signaling through inhibition of calcineurin and PP2A . Positive_regulation AKT2 FOXO1 20709952 2312824 However , whereas the [PI(3)K/Akt] regulation of Rag transcription is *mediated* by , we show in this study that the MEK/ERK pathway coordinates with the regulation of Rag by controlling the phosphorylation and turnover of E47 and its consequential binding to the Rag enhancer regions . Positive_regulation AKT2 FOXO1 22068162 2528240 The effect of progranulin on proliferation and [Akt] *activation* and subsequent effects of phosphorylation were assessed in vitro . Positive_regulation AKT2 FOXO1 24424889 2901241 Furthermore , MHY-449 reduced the phosphorylation of [Akt] and FoxO1 and *induced* the translocation of from cytoplasm to nucleus as shown by western blot analysis . Positive_regulation AKT2 FOXO1 24874427 2945693 mediated *activation* of [Akt] plays a critical role in vascular homeostasis . Positive_regulation AKT2 FOXO1 24874427 2945700 Moreover , mediated feedback *activation* of [Akt] maintains growth factor responsive Akt/mTORC1 activity within a homeostatic range . Positive_regulation AKT2 FUT4 20506505 2307949 These data suggested that not only *activates* MAPK and [PI3K/Akt] signals , but also promotes the crosstalk among these signaling pathways . Positive_regulation AKT2 FUT4 21337384 2411174 The results showed that overexpression *up-regulated* phosphorylation of ERK1/2 and [Akt] which was inhibited by CPA in dose dependent manner . Positive_regulation AKT2 FUT4 23887626 2821549 Moreover , *induced* activation of phosphatidylinositol 3-kinase [(PI3K)/Akt] , and inactivation of GSK3ß and nuclear translocation of NF-?B , resulting in increased Snail and MMP-9 expression and greater cell motility . Positive_regulation AKT2 GLP1R 22182839 2537189 Transgene expression restored *dependent* stimulation of cAMP and [Akt] phosphorylation in isolated islets , conferred GLP-1R dependent stimulation of ß cell proliferation , and was sufficient for restoration of GLP-1 stimulated insulin secretion in perifused islets . Positive_regulation AKT2 GLP1R 23900416 2839799 Hindbrain mediated suppression of food intake *requires* a PI3K dependent decrease in phosphorylation of membrane bound [Akt] . Positive_regulation AKT2 GLP1R 24269940 2893114 Finally , GW exerted anti-apoptotic effects via interfering with *dependent* [Akt/Bcl-2] and Bcl-xl/caspase-3 signaling pathways . Positive_regulation AKT2 GPR115 17329974 1707083 [Akt/TSC/mTOR] *activation* by the KSHV : emerging insights into the molecular oncogenesis and treatment of Kaposi 's sarcoma . Positive_regulation AKT2 GPR115 17949438 1825951 *induced* [Akt] activity in cellular proliferation and apoptosis . Positive_regulation AKT2 GPR132 17329974 1707072 [Akt/TSC/mTOR] *activation* by the KSHV : emerging insights into the molecular oncogenesis and treatment of Kaposi 's sarcoma . Positive_regulation AKT2 GPR132 17949438 1825940 *induced* [Akt] activity in cellular proliferation and apoptosis . Positive_regulation AKT2 GPR87 17329974 1707152 [Akt/TSC/mTOR] *activation* by the KSHV : emerging insights into the molecular oncogenesis and treatment of Kaposi 's sarcoma . Positive_regulation AKT2 GPR87 17949438 1826020 *induced* [Akt] activity in cellular proliferation and apoptosis . Positive_regulation AKT2 HBEGF 11882602 919641 PD98059 inhibited HB-EGF induced ERK activation , whereas it had no effect on [Akt] *activation* by . Positive_regulation AKT2 HBEGF 15380451 1298474 *induced* phosphorylation of ERK , p38 MAPK and [Akt] , which were suppressed by ZD1839 . Positive_regulation AKT2 HBEGF 15952178 1440641 The phosphatidylinositol 3'-kinase (PI3K) inhibitors LY294002 and wortmannin , and the MAPK/extracellular signal regulated kinase ( ERK ) kinase ( MEK ) inhibitors U0126 and PD98059 , reduced HB-EGF induced BrdU incorporation into cultures , and *enhanced* phosphorylation of [Akt] and ERK , implying a role for PI3K/Akt and MEK/ERK signaling in HB-EGF stimulated cell proliferation . Positive_regulation AKT2 HBEGF 16034135 1436430 In this report , we show that in intestinal epithelial cells , *triggered* PI3K dependent phosphorylation of [Akt] . Positive_regulation AKT2 HBEGF 16799022 1579191 On the other hand , AKT phosphorylation was much more sensitive to PP2 than ERK or EGFR phosphorylation because 3.13 microM PP2 effectively inhibited wound- or *induced* [AKT] phosphorylation . Positive_regulation AKT2 HBEGF 19470173 2091040 The induced clustering of EGFR was observed minimally after 5 min of integrin crosslinking but was more prominent after 15 min . EGFR clustering had minimal effect on the phosphorylation of [Akt] or Erk1 ,2 in response to EGF in suspended cells or in *response* to in adherent cells . Positive_regulation AKT2 HBEGF 19559571 2110520 Finally , the induced *activation* of [Akt] and eNOS was suppressed by VEGF competitive antagonist , CBO-P11 . Positive_regulation AKT2 HBEGF 21289053 2410023 However , general metalloprotease inhibition , as well as specific inhibitors of heparin binding EGF-like growth factor ( ) , *prevented* both EGFR and downstream [Akt] activation . Positive_regulation AKT2 ID1 17855368 1818122 Furthermore , our results revealed that this effect was regulated by induced [Akt] *activation* through promoting the binding activity between Cav-1 and protein phosphatase 2A . Positive_regulation AKT2 ID1 19079342 2030881 *activates* [Akt] mediated Wnt signaling and p27 ( Kip1 ) phosphorylation through PTEN inhibition . Positive_regulation AKT2 IFI27 12768542 1094563 Second , ACTH-R triggers cAMP/PKA mediated antimitogenic mechanisms comprised of [Akt/PKB] dephosphorylation/deactivation , c-Myc protein degradation , and ( Kip1 ) protein *induction* . Positive_regulation AKT2 IFI27 19954644 2172453 Western blot results showed that the [Akt] phosphorylation and cyclin D1 expression was significantly decreased ( P < 0.01 ) , and the expression of ( KIP1 ) and p21 ( WAF1/CIPI ) *increased* . Positive_regulation AKT2 IL1B 11022128 738141 Furthermore , anti-inflammatory cytokines such as IL-4 and IL-10 that block IL-1b induced NFkappaB activation also attenuate *induced* [Akt] phosphorylation , despite the fact that IL-4 and IL-10 in isolation induced Akt phosphorylation . Positive_regulation AKT2 IL1B 11605009 871541 Pretreatment with SB203085 inhibited *induced* p38 and [AKT] phosphorylation . Positive_regulation AKT2 IL1B 11976320 953891 In human embryonic kidney 293 cells , *induces* IkappaB kinase beta (IKKbeta) activation , IkappaBalpha degradation , NF-kappaB transactivation , and weak [Akt] activation . Positive_regulation AKT2 IL1B 12126643 966021 P38 mitogen activated protein kinase (MAPK) was activated after 5min of IL-1beta treatment , whereas the extracellular signal regulated kinases , the c-jun amino-terminal kinases , and protein kinase [B/Akt] were not *activated* by . Positive_regulation AKT2 IL1B 12483539 1024811 Exogenous expression of either SHPS-1 mutants that lack SHP-2 binding function or a dominant negative mutant of SHP-2 markedly inhibited the *activation* of Erk 1/2 and [Akt] by , whereas wild type SHPS-1 did not . Positive_regulation AKT2 IL1B 12516562 1027882 *induced* phosphorylation of [PKB/Akt] depends on the presence of IRAK-1 . Positive_regulation AKT2 IL1B 12874320 1115030 A dominant negative mutant ( Mal-P/H ) of MyD88 adapter-like protein (Mal) , a protein with homology to MyD88 , failed to inhibit LPS- or *induced* [Akt] activity . Positive_regulation AKT2 IL1B 14612947 1163429 The PLC-PKC cascade is required for *dependent* Erk and [Akt] activation : their role in proliferation . Positive_regulation AKT2 IL1B 14612947 1163434 Pharmacological inhibition of the PLC-PKC cascade by using specific inhibitor for PLC-gamma ( U73122 ) and PKC ( GFX ) strongly inhibited *induced* Erk and [Akt] activation . Positive_regulation AKT2 IL1B 14612947 1163447 Taken together , our results suggest that a SHPS-1-PLC-gamma complex activate the PLC-PKC cascade , which is required for the activation of *dependent* Erk and [Akt] signalings and cell proliferation . Positive_regulation AKT2 IL1B 14764725 1207381 Antioxidant treatment of LPS stimulated neutrophils also inhibited the production of proinflammatory cytokines ( TNF-alpha , macrophage inflammatory protein-2 , and ) , as well as *activation* of the kinases IkappaB kinase alpha , IkappaB kinase beta , p38 , [Akt] , and extracellular receptor activated kinases 1 and 2 . Positive_regulation AKT2 IL1B 17291458 1710971 Curcumin inhibited the *induced* stimulation of up-stream protein kinase B [Akt] . Positive_regulation AKT2 IL1B 17299794 1718840 Src , PDGFR , and [PI3K/Akt] *mediated* the effects of because pretreatment with PP1 , AG1296 , and wortmannin also abrogated IL-1beta stimulated Src , PDGFR , and Akt phosphorylation , respectively . Positive_regulation AKT2 IL1B 17645739 1793264 Interestingly , Dex attenuated *mediated* activation of p38 MAPK and JNK , but not of [AKT] . Positive_regulation AKT2 IL1B 17920534 1804184 SA981 at a concentration of 100 microM partially inhibited *induced* phosphorylation of p38MAPK and [Akt] ( 12.0 % and 36.1 % inhibition of each total amount of phosphoprotein under IL-1beta coexistence condition , respectively ) . Positive_regulation AKT2 IL1B 20067833 2212260 These results indicated that glucose induced endogenous expression *increased* betaTC-6 cells apoptosis by inhibiting , at least in part , [IRS-2/Akt] mediated signalling through SOCS-1 upregulation . Positive_regulation AKT2 INPP4B 24288008 2926680 We further demonstrate that *regulates* [PI3K/Akt] signaling and exerts a tumor suppressor effect , impacting the proliferative , invasive , and tumorigenic capacity of melanoma cells . Positive_regulation AKT2 IRS4 10594015 654761 also *promoted* the activation of [PKB/Akt] and BAD phosphorylation during insulin stimulation ; Positive_regulation AKT2 IRS4 19029952 2029401 Once expressed , as well as binding to E1A and the insulin receptor , remains tyrosine phosphorylated and constitutively associates with the regulatory p85 subunit of phosphoinositide 3 kinase , *resulting* in the phosphorylation of [Akt] ( causing activation ) and GSK-3beta ( causing inhibition ) . Positive_regulation AKT2 ITGAL 18209096 1857848 CD28 ( - ) T cells , which are overrepresented in RA patients , have high cell surface expression and *induce* [Akt] phosphorylation in FLS more potently than their CD28 ( + ) counterparts . Positive_regulation AKT2 ITGB2 14960575 1227752 We have identified Vav , a guanine nucleotide exchange factor for Rac-1 , and PI3K/Akt , as regulators of the activation and inactivation phases of the activity of Rac-1 , respectively , in the context of LFA-1 signaling based on the following experimental evidence : ( i ) *induced* activation of Vav and [PI3K/Akt] with kinetics consistent with a regulatory role for these molecules on Rac-1 , ( ii ) overexpression of a constitutively active Vav mutant induces activation of Rac independently of LFA-1 stimulation whereas overexpression of a dominant negative Vav mutant blocks LFA-1 mediated Rac activation , ( iii ) pharmacological inhibition of PI3K/Akt prevented the fall in the activity of Rac-1 after its initial activation but had no effect on Vav activity , and ( iv ) overexpression of a dominant negative or a constitutively active Akt-1 induced or inhibited , respectively , Rac-1 activity . Positive_regulation AKT2 ITGB2 19630789 2112989 In microglia , fibrinogen mediates *activation* of [Akt] and Rho via the integrin receptor , while in neurons fibrinogen induces phosphorylation of epidermal growth factor (EGF) receptor via the alphavbeta3 integrin . Positive_regulation AKT2 LAMB3 22673183 2669803 upregulation was also observed in CAFs and NBFs , but at a lower level than in InFs . Laminin-332 *induced* [Akt] ( Ser473 ) phosphorylation by binding to integrin a3ß1 . Positive_regulation AKT2 MAOA 24865426 2945518 dependent activation of neuropilin-1 *promoted* [AKT/FOXO1/TWIST1] signaling , allowing FOXO1 binding at the TWIST1 promoter . Positive_regulation AKT2 MAP2K6 10331501 614639 However , neither two PI-3 kinase inhibitors , wortmannin and LY294002 , nor inhibitor PD98059 inhibited GM-CSF induced survival of eosinophils , although wortmannin and PD98059 *inhibited* GM-CSF induced [Akt] phosphorylation and MAP kinase activation in eosinophils , respectively . Positive_regulation AKT2 MAP2K6 10872812 707107 While the IGF-I induced activation of [PKB/Akt] was *inhibited* by PI3-K inhibitor LY294002 but not by inhibitor PD98059 , the activation of both MEK and ERK by IGF-I was inhibited by both . Positive_regulation AKT2 MAP2K6 10945642 721598 Phosphorylation of the cell survival promoting kinase Akt ( protein kinase B ) resulted from SF/HGF treatment of U373 cells , and both [Akt] phosphorylation and cell survival induced by SF/HGF were *inhibited* by phosphatidylinositol 3-kinase inhibitors but not by inhibitors of or protein kinase C. Cytoprotection by SF/HGF in vitro was also inhibited by transient expression of dominant negative Akt . Positive_regulation AKT2 MAP2K6 11454948 837891 Therefore , it is not clear whether inhibition of activation of [Akt] *resulted* from selective inhibition of or from additional actions on other unidentified common pathways . Positive_regulation AKT2 MAP2K6 11479233 842226 Inhibitors of ( U0126 ) and PI3K ( LY294002 ) *blocked* p42/p44 ( erk ) and [Akt] , respectively , and partially blocked HGF induced production of IL-8 and VEGF , whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A . Positive_regulation AKT2 MAP2K6 12114408 964048 Our results suggest the combination of paclitaxel and inhibitor *leads* to down-regulation of the [PI3K-Akt] signaling in addition to the proapoptotic effects of paclitaxel and MEK inhibitor alone . Positive_regulation AKT2 MAP2K6 12181443 977631 [Akt] activation induced by lysophosphatidic acid and sphingosine-1-phosphate *requires* both and p38 mitogen activated protein kinase and is cell-line specific . Positive_regulation AKT2 MAP2K6 12181443 977761 However , epidermal growth factor , thrombin , and endothelin-1 stimulated [Akt] S473 phosphorylation *require* p38 but not . Positive_regulation AKT2 MAP2K6 14719071 1197707 In cisplatin-resistant UM-SCC-23 in culture , which we have established , the protein levels of Ras , Raf-1 and were drastically elevated compared to parent UM-SCC-23 , and ERK and [Akt] signals were constitutively *activated* . Positive_regulation AKT2 MAP2K6 14993781 1216071 Furthermore , using Ad MEK DN , a dominant negative form of MEK , it was found that negatively *regulates* [Akt] phosphorylation upon IGF-1 stimulation . Positive_regulation AKT2 MAP2K6 15607817 1357046 Furthermore , U0126 and LY294002 , which respectively inhibit *induced* ERK phosphorylation and PI3 kinase mediated [Akt] phosphorylation had distinct effects on C3a induced responses . Positive_regulation AKT2 MAP2K6 15618457 1387746 The PI3K inhibitors wortmannin and LY-294002 and an [Akt] *inhibitor* , 1-L-6-hydroxymethyl-chiro-inositol 2- ( R ) -2-O-methyl-3-O-octadecylcarbonate , but not a inhibitor PD-98059 , blocked isoproterenol mediated eosinophil survival . Positive_regulation AKT2 MAP2K6 15767555 1384171 These events were associated with marked down-regulation of Raf-1 , , and ERK phosphorylation , diminished [Akt] *activation* , and enhanced phosphorylation of c-Jun NH2-terminal kinase (JNK) . Positive_regulation AKT2 MAP2K6 15801908 1432358 The ( MAPK/ERK kinase ) inhibitors PD98059 and U0126 blocked IGF-I stimulated ERK phosphorylation but did not *block* the phosphorylation of [Akt] and did not decrease proteoglycan synthesis . Positive_regulation AKT2 MAP2K6 16176063 1457728 The LPA induced phosphorylation of ERK 1/2 and CREB was blocked by inhibition of PI3K , PKC and , but that of [Akt] was only *inhibited* by wortmannin , the PI3K inhibitor . Positive_regulation AKT2 MAP2K6 16181409 1461918 The importance of these pathways was further confirmed by the activation of both ERK , in a *dependent* manner , and [Akt] , via PI3K . Positive_regulation AKT2 MAP2K6 16877565 1638819 However , inhibitors of Raf-1 and or a dominant negative ERK mutant *blocked* FKN induced ERK , but not [Akt] and eNOS , phosphorylation . Positive_regulation AKT2 MAP2K6 18586026 1953393 These data show that TGF-beta induced NFkappaB activation is through mediated [AKT] *activation* , which is essential for TGF-beta to support of osteoclast survival . Positive_regulation AKT2 MAP2K6 18656513 1972869 was *required* for phosphorylation of ERK and CREB , but not [Akt] , whereas G ( 0 ) /G ( i ) -proteins were necessary for phosphorylation of Akt and CREB , and cGMP was necessary for Akt phosphorylation . Positive_regulation AKT2 MAP2K6 20542106 2301975 Activation of these pathways by ATP seemed to be independent , since LY294002 and U0126 , inhibitors of PI3K and , did not *block* the activation of ERK and [AKT] , respectively , although each compound blocked its respective target . Positive_regulation AKT2 MAP2K6 20668435 2317124 In addition , DHA caused [AKT] and ERK activation in a time dependent manner , and the DHA induced HO-1 upregulation could be *attenuated* by PI-3 kinase/AKT and inhibitors . Positive_regulation AKT2 MAP2K6 21557297 2464090 Pharmacologic inhibition of EGFR , , and PI3K kinase activity in SCC10A *reduced* phosphorylated levels of ERK-1/2 and [AKT] , production of MMP-9 and sE-cad , cell migration and invasion , and expressional changes of EMT markers ( E-cadherin and N-cadherin ) induced by EGF , indicating that EGFR activation promotes cell migration and invasion via ERK-1/2 and PI3K regulated MMP-9/E-cadherin signaling pathways . Positive_regulation AKT2 MAP2K6 22674052 2719221 Besides , expression of [phosphorylated-AKT] and phosphorylated-ERK1/2 in fluoxetine treated NSCs was effectively *blocked* ( P < 0.05 ) by both PI3-K inhibitor ( LY294002 ) and inhibitor ( PD98059 ) . Positive_regulation AKT2 MAP2K6 22964641 2827261 In defining each pathway 's contributions , we found that [AKT] inhibition alone maximally *induced* GAPDH nuclear accumulation , whereas inhibition alone had no effect on GAPDH localization . Positive_regulation AKT2 MAP2K6 23199222 2730625 Furthermore , specific PI3K inhibitors abrogated the phosphorylation of Erk1/2 , while inhibition of did not *prevent* the phosphorylation of [Akt] . Positive_regulation AKT2 MAP2K6 23817184 2815723 [Akt] was also activated under the basal conditions , and the activation was *suppressed* by a inhibitor and an ERK1/2 inhibitor . Positive_regulation AKT2 MAP2K6 24530412 2924301 It is noteworthy that a tyrosine kinase receptor inhibitor , K252a , an inhibitor ( U0126 ) , and a PI3Kinase-Akt inhibitor ( LY294002 ) remarkably *attenuated* TrkB , ERK , and [Akt] phosphorylation as well as increase of OPN mRNA expression in the HCEM cells , respectively . Positive_regulation AKT2 MAP2K6 24652289 2934701 Nearly all IRS1 Ser(P)/Thr ( P ) residues were stimulated by insulin and significantly suppressed by PI3K inhibition ; fewer were suppressed by [Akt] or mTOR inhibition , and none were *suppressed* by inhibition . Positive_regulation AKT2 MIP 24449419 2923101 Cadmium selectively *induces* and COX-2 through PTEN mediated [Akt] activation in RAW264.7 cells . Positive_regulation AKT2 NGFR 22880054 2641718 Whereas Src kinases are often required for Syk activation , we show here that [PI3K/Akt] *activation* and autocrine IL-10 production by involves the Src family kinase Fyn . Positive_regulation AKT2 PECAM1 15632208 1387984 Sphingosine kinase-1 enhances endothelial cell survival through a dependent *activation* of [PI-3K/Akt] and regulation of Bcl-2 family members . Positive_regulation AKT2 PECAM1 16118242 1454345 *Role* of in the shear-stress induced activation of [Akt] and the endothelial nitric oxide synthase (eNOS) in endothelial cells . Positive_regulation AKT2 PECAM1 16118242 1454356 Down-regulation of using a siRNA approach *attenuated* the shear-stress induced phosphorylation of [Akt] and eNOS , as well as the shear-stress induced accumulation of cyclic GMP levels while the shear-stress induced phosphorylation of AMPK remained intact . Positive_regulation AKT2 PECAM1 19390054 2094936 Inward remodeling was associated with *dependent* NFkappaB activation , surface adhesion molecule expression , and leukocyte infiltration as well as [Akt] activation and vascular cell proliferation . Positive_regulation AKT2 PECAM1 23292117 2742032 EGCG inhibited HPV-16 oncoprotein induced angiogenesis conferred by NSCLC through the inhibition of HIF-1a protein expression and HIF-1a dependent expression of VEGF , IL-8 , and as well as *activation* of [Akt] , suggesting that HIF-1a may be a potential target of EGCG against HPV related NSCLC angiogenesis . Positive_regulation AKT2 PLAT 17498240 1739844 Consistent with neurotrophic effects , *activated* Raf-K/ERK , PKC and [PI3-K/Akt] , 5-60 min after treatment . Positive_regulation AKT2 PLAT 22162045 2549121 We found that *induces* a catalytic independent rapid and sustained activation of extracellular signal regulated kinase ( ERK ) 1/2 , Jun N-terminal kinase (JNK) , [Akt] , and p38 signaling pathways . Positive_regulation AKT2 PLAT 23280993 2758107 Furthermore , rADAMTS13 downregulated *induced* phosphorylation of [Akt] and activation of RhoA . Positive_regulation AKT2 PLAT 23562854 2778000 Glucose deprivation induced activation of [PI3K-Akt-GSK3ß] , p38 and AMPK , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation AKT2 PLAU 12545160 1051058 Downregulation of *inhibits* migration and [PI3k/Akt] signaling in glioblastoma cells . Positive_regulation AKT2 PLAU 15874933 1405689 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , [Akt] , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Positive_regulation AKT2 PRODH 22796327 2660077 The results provide evidence that is essential in proline protection against hydrogen peroxide mediated cell death and that proline/PRODH helps *activate* [Akt] in cancer cells . Positive_regulation AKT2 S1PR3 12385647 1034864 We previously demonstrated that sphingosine 1-phosphate (S1P) induced PLD activation via the G-protein coupled receptor endothelial differentiation gene (EDG) <3/S1P(3)> was *involved* in S1P induced stimulation of PI 3-kinase and [Akt] . Positive_regulation AKT2 S1PR3 14657000 1202005 mediated [Akt] *activation* and cross-talk with platelet derived growth factor receptor ( PDGFR ) . Positive_regulation AKT2 S1PR3 14657000 1202008 Using mouse embryonic fibroblasts ( MEFs ) from S1P receptor knockout mice , we show here that was *required* for S473 phosphorylation of [Akt] by S1P . Positive_regulation AKT2 S1PR3 15334188 1291018 Finally , S1P also protects endothelial cells from apoptosis through *activation* of phosphatidylinositol [3-kinase/Akt/eNOS] via S1P(1) and receptors . Positive_regulation AKT2 SCGB3A1 16266985 1478899 , an inhibitor of cell growth , invasion , and [AKT] *activation* . Positive_regulation AKT2 SLC38A3 11208554 787168 *induction* of [Akt] phosphorylation was inhibited by the phosphoinositide 3-kinase ( PI 3-kinase ) inhibitors LY-294002 ( 10 microM ) and wortmannin ( 200 nM ) but not by the mitogen activated protein kinase kinase 1 inhibitor PD-98059 ( 50 microM ) . Positive_regulation AKT2 SLC38A3 11208554 787173 The p38 kinase inhibitor SB-203580 inhibited *induction* of [Akt] phosphorylation and activation at a concentration ( 10 microM ) 10-fold higher than necessary to block p38 kinase ( 1 microM ) , suggesting the possible involvement of kinase activities other than p38 kinase . Positive_regulation AKT2 SLC38A3 15331357 1287937 *induction* of [Akt] activation was reduced by > 60 % by both dominant negative Ras and Rho and by 30 % by dominant negative Cdc42 . Positive_regulation AKT2 SLC38A3 15351698 1292591 D2 , a CCKB receptor antagonist , inhibited *induction* of [Akt] phosphorylation , measured by Western blots with anti-phospho-Akt antibodies . Positive_regulation AKT2 SLC38A3 15351698 1292594 The intracellular calcium chelator BAPTA-AM , but not the PKC inhibitor GF109203X , blocked *induction* of [Akt] . Positive_regulation AKT2 SLC38A3 15351698 1292598 In conclusion , *induces* [Akt] through activation of CCKB receptors and of intracellular calcium dependent , PKC independent , pathways . Positive_regulation AKT2 SLC38A3 23376640 2747986 In addition , knockdown of STAT3 expression significantly attenuated induced [PI3K/Akt] *activation* , COX-2 expression , and cell proliferation . Positive_regulation AKT2 SPHK1 14742298 1242757 S1P activated [Akt] and ERK within minutes , and inhibition of *blocked* RSV induced ERK and Akt activation , leading to accelerated cell death after viral infection . Positive_regulation AKT2 SPHK1 15210766 1262032 Blocking acid ceramidase but not activity in alveolar macrophages *led* to decreased ERK and [Akt] activity and induction of cell death . Positive_regulation AKT2 SPHK1 16164409 1456257 Notably , activation of the PI3K downstream mediator [PKB/Akt] by GPCR ligands *involves* the activity of and is independent of EGFR signal transactivation . Positive_regulation AKT2 SPHK1 17114809 1677156 Tumor necrosis factor-alpha stimulated cell proliferation is mediated through *dependent* [Akt] activation and cyclin D expression . Positive_regulation AKT2 SPHK1 17114809 1677179 In contrast , TNF-alpha stimulated [Akt] phosphorylation , which was also required for DNA synthesis , was *attenuated* by inhibition or SphK1 knockdown by small interfering RNA . Positive_regulation AKT2 SPHK1 17114809 1677198 We conclude that *dependent* [Akt] activation plays a significant role in TNF-alpha induced cyclin D expression and cell proliferation . Positive_regulation AKT2 SPHK1 21163859 2407759 Loss of *diminished* ASM mediated [AKT] phosphorylation , but exogenous S1P induced AKT activation in hepatocytes . Positive_regulation AKT2 SPHK1 21848514 2510101 However , inhibition did *diminish* EGF ( epidermal growth factor ) -driven increases in S1P levels and [Akt] ( also known as protein kinase B ) /ERK ( extracellular-signal regulated kinase ) phosphorylation . Positive_regulation AKT2 SPHK1 24572701 2919812 In vitro , the inhibition of induced cell death in colon cancer cell lines and *attenuated* the serum dependent [PI3K/Akt] signaling . Positive_regulation AKT2 TGM2 18381937 1892945 *regulates* focal adhesion [kinase/AKT] activation by modulating PTEN expression in pancreatic cancer cells . Positive_regulation AKT2 TLR7 23979601 2850585 Both phosphatidylinositol 3-kinase [(PI3K)-Akt] and p38 mitogen activated protein kinase (MAPK) signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Positive_regulation AKT2 TLR7 23979601 2850946 These data describe a novel role for p38a-MK2/3 in regulating induced [Akt] *activation* in macrophages . Positive_regulation AKT2 TNF 10485710 644494 *activates* phosphatidylinositol-3-OH kinase ( PI(3)K ) and its downstream target [Akt] ( protein kinase B ) . Positive_regulation AKT2 TNF 10748004 690715 Here we report that both and IL-1 *activate* the anti-apoptotic protein kinase [Akt] in growth factor and serum deprived EC , assessed by Western blotting for phospho-Akt . Positive_regulation AKT2 TNF 11067939 747579 CPPD crystals were observed to *induce* a robust and transient activation of ERK1 , ERK2 , and [Akt] , whereas produced only a modest and delayed activation of Akt . Positive_regulation AKT2 TNF 11067939 747593 In the *presence* of , [Akt] activity was enhanced , and CPPD crystal induced activation of ERK1 and ERK2 was more sustained than with CPPD crystals alone , but TNF-alpha itself reduced the basal phosphotransferase activities of these MAP kinases . Positive_regulation AKT2 TNF 11247802 793339 The *activation* of phosphatidylinositol (PI) 3-kinase and [Akt/protein] kinase B (PKB) by and their roles on stimulation of protein synthesis were investigated in cultured neonatal rat cardiac myocytes . Positive_regulation AKT2 TNF 11247802 793348 *induced* marked activation of PI3-kinase and [Akt/PKB] , and the activation of PI3-kinase and Akt/PKB was rapid ( maximal at 10 and 15 min , respectively ) and concentration dependent . Positive_regulation AKT2 TNF 11247802 793356 [Akt/PKB] *activation* by was inhibited by a PI3-kinase-specific inhibitor LY-294002 and adenovirus mediated expression of a dominant negative mutant of PI3-kinase , indicating that TNF-alpha activates Akt/PKB through PI3-kinase activation . Positive_regulation AKT2 TNF 11356844 834413 *Activation* of phosphatidylinositol (PI) [3-kinase/Akt] signaling by activates IKK and NF-kappaB . Positive_regulation AKT2 TNF 11356844 834462 *activated* [Akt] in PC-3 cells , but not in DU145 cells , and the ability of TNF to activate NF-kappaB was blocked by pharmacological inhibition of PI 3-kinase activity in PC-3 cells , but not in DU145 cells . Positive_regulation AKT2 TNF 11418646 830254 induced *activations* of PI3K and [Akt] were inhibited by DMS . Positive_regulation AKT2 TNF 11423913 831042 These results suggest that *induced* MAP kinase and [PI3-kinase/Akt] signaling play important roles in protecting BAE cells from TNF cytotoxicity . Positive_regulation AKT2 TNF 11465707 839731 The levels of phosphorylated Akt and [Akt] kinase activity were *increased* by stimulation of primary RASF with ( 10 ng/ml ) . Positive_regulation AKT2 TNF 12034358 948248 In SAS cells , *induced* the phosphorylation of [Akt] at both Ser473 and Thr308 , causing the activation of Akt , and also induced the phosphorylation and degradation of IkappaB ( inhibitor of NFkappaB ) . Positive_regulation AKT2 TNF 12048203 968532 In this study , we show that [AKT2] in epithelial cells is *activated* by UV-C irradiation , heat shock , and hyperosmolarity as well as by through a phosphatidylinositol 3-kinase dependent pathway . Positive_regulation AKT2 TNF 12052823 968763 Treatment with two pharmacological inhibitors of NF-kappa B , SN50 and N-tosyl-l-phenylalanine chloromethyl ketone ( TPCK ) , blocks induced [Akt] *activation* . Positive_regulation AKT2 TNF 12052823 968770 These results suggest that NF-kappa B is required for mediated [Akt] *activation* and that it lies upstream of the stimulation of Akt . Positive_regulation AKT2 TNF 12060576 952776 Strikingly , the *activation* of p42 ( mapk/erk2 ) and [Akt] by was also inhibited in the presence of NaCl . Positive_regulation AKT2 TNF 12086898 895222 PI3K inhibition significantly enhanced the antiproliferative and proapoptotic effects of TNF-alpha in both cell lines , Ly294002 also blocked induced [Akt] *activation* but failed to alter cytoplasmic IkappaBalpha degradation or subsequent NF-kappaB nuclear translocation . Positive_regulation AKT2 TNF 12483539 1024790 In addition , PP1 substantially inhibited the IL-2beta- and dependent *activation* of Erk 1/2 and [Akt] . Positive_regulation AKT2 TNF 12714600 1100551 Phosphorylation of [Akt] and the mammalian target of rapamycin ( but not extracellular regulated kinase or PKCzeta ) in *response* to was inhibited by aspirin treatment . Positive_regulation AKT2 TNF 12748063 1119605 Additionally , ethanol exposed cells display a blunting of induced [Akt] *activation* and Bcl-2 antagonist of cell death phosphorylation that may account , in part , for the increased sensitivity of the mitochondria to Bax mediated damage . Positive_regulation AKT2 TNF 14532277 1174871 Phosphorylation of VEGFR2 at Tyr-801 and Tyr-1175 , the critical sites for VEGF induced PI3K-Akt signaling , was not involved in mediated [Akt] *activation* . Positive_regulation AKT2 TNF 14532277 1174891 Furthermore , but not VEGF *induced* activation of VEGFR2 , [Akt] , and EC migration are blunted in EC genetically deficient with Etk . Positive_regulation AKT2 TNF 14532277 1174903 Taken together , our data demonstrated that induces transactivation between Etk and VEGFR2 , and Etk directly *activates* [PI3K-Akt] angiogenic signaling independent of VEGF induced VEGFR2-PI3K-Akt signaling pathway . Positive_regulation AKT2 TNF 14623898 1200890 Down-regulation of PTEN by NIK/NF-kappaB results in activation of the PI3K/Akt pathway and augmentation of *induced* [PI3K/Akt] stimulation . Positive_regulation AKT2 TNF 14630924 1201130 Furthermore , flavopiridol suppressed induced *activation* of [Akt] . Positive_regulation AKT2 TNF 14764725 1207380 Antioxidant treatment of LPS stimulated neutrophils also inhibited the production of proinflammatory cytokines ( , macrophage inflammatory protein-2 , and IL-1beta ) , as well as *activation* of the kinases IkappaB kinase alpha , IkappaB kinase beta , p38 , [Akt] , and extracellular receptor activated kinases 1 and 2 . Positive_regulation AKT2 TNF 15265936 1275719 Celecoxib also inhibited the *induced* interaction of [Akt] with I kappa B alpha kinase (IKK) . Positive_regulation AKT2 TNF 15358188 1293389 Western blot analyses revealed that [Akt] , which acts as a survival factor in cells , was activated in SMP30 , but not mock , transfectants either in the *presence* or absence of plus Act-D . Positive_regulation AKT2 TNF 15530848 1332709 In contrast , antioxidants did not prevent *induced* [Akt] and NF-kappaB activation . Positive_regulation AKT2 TNF 15646653 1349890 Stimulation of human neutrophils with granulocyte colony stimulating factor ( G-CSF ) , granulocyte-macrophage CSF (GM-CSF) , or *resulted* in phosphorylation of [Akt] , the potency being GM-CSF > G-CSF = TNF , which was inhibited by wortmannin . Positive_regulation AKT2 TNF 15710601 1395741 Evodiamine also inhibited induced [Akt] *activation* and its association with IKK . Positive_regulation AKT2 TNF 15746249 1403175 Collectively , our results suggest that *induces* the caspase dependent degradation of [Akt] via the cleavage and ubiquitination of Akt , which results in its degradation through the 26S proteasome . Positive_regulation AKT2 TNF 15792609 1386788 By stimulation of in AM-1 cells , the phosphorylation of [Akt] ( Ser473 ) and p44/42 mitogen activated protein kinase (MAPK) ( Thr202/Tyr204 ) was markedly *increased* in TNFalpha concentration and time dependent manner . Positive_regulation AKT2 TNF 15792609 1386817 Meanwhile , pretreatment with LY294002 , phosphatidylinositol-3-OH kinase (PI3K) inhibitor , could inhibit both *induced* phosphorylation of [Akt] ( Ser473 ) and p44/42 MAPK ( Thr202/Tyr204 ) . Positive_regulation AKT2 TNF 15793306 1387007 Methyl-beta-cyclodextrin did not alter total cell surface expression of TNFR1 or TNF induced degradation of IkappaBalpha , a measure of nuclear factor-kappaB activation , but it did inhibit *induced* phosphorylation of [Akt] , a measure of phosphatidylinositol-3 kinase activation . Positive_regulation AKT2 TNF 15808421 1391134 Similarly , DEM and CDNB inhibited *induced* [Akt] and eNOS phosphorylation , suggesting that thiol modification is involved in eNOS inductive pathways . Positive_regulation AKT2 TNF 15841081 1403986 However , gefitinib inhibited the induced *activation* of MAPKs and [Akt] . Positive_regulation AKT2 TNF 15953363 1421742 It inhibits *induced* PI3-kinase , [Akt] and NF-kappaB activation in these cells . Positive_regulation AKT2 TNF 16025396 1435605 *activated* the phosphorylation of p44/42 MAPK , p38 MAPK , SAPK/JNK and [Akt] in mesangial cells . Positive_regulation AKT2 TNF 16025396 1435621 PGE1 inhibited the *induced* phosphorylation of SAPK/JNK and [Akt] , but not p44/42 MAPK and p38 MAPK . Positive_regulation AKT2 TNF 16051251 1525211 Statin treatment of cells abrogated *induced* [Akt] phosphorylation and p65 nuclear translocation . Positive_regulation AKT2 TNF 16140562 1499247 These results suggested that TNFalpha induced both cell survival and apoptosis pathways in ameloblastoma and potential of TNFalpha in inducing apoptosis can be improved by inhibiting *induced* [Akt] and p44/42 mitogen activated protein kinase (MAPK) cell survival pathways . Positive_regulation AKT2 TNF 16230421 1470274 4-HPR also inhibited induced [Akt] *activation* linked with IKK activation . Positive_regulation AKT2 TNF 16269668 1502345 In human endothelial cells , we found that eNOS activation by is time dependent and *requires* activation of [Akt] , a known eNOS activator . Positive_regulation AKT2 TNF 16291729 1526064 *Activation* of MAPK and [Akt] by anti-HER2/neu inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation AKT2 TNF 16354764 1519359 Moreover , *induced* phosphorylation of [Akt] and extracellular signal regulated kinase ( ERK ) was blocked by glabridin treatment in HUVECs . Positive_regulation AKT2 TNF 16361577 1493167 However , *induced* [Akt] phosphorylation and IkappaB degradation were observed much less often in PC-9/ZD2001 cells than in PC-9 cells or PC-9/ZD2001R cells . Positive_regulation AKT2 TNF 16448212 1521716 PJ also abolished induced [AKT] *activation* , needed for NFkappaB activity . Positive_regulation AKT2 TNF 16794257 1631642 Quercetin also inhibited *induced* PI 3-kinase activity , [Akt] phosphorylation , intracellular H ( 2 ) O ( 2 ) production , NF-kappaB transactivation , IL-8 promoter activity , and steady-state mRNA levels , consistent with the notion that quercetin inhibits chemokine expression by attenuating NF-kappaB transactivation via a PI 3-kinase/Akt dependent pathway . Positive_regulation AKT2 TNF 16798728 1638519 Inhibition of Rac1 does not modulate induced ERK1/2 and [Akt] *activation* . Positive_regulation AKT2 TNF 16924232 1692172 Genetic deletion of PKR abrogates induced *activation* of IkappaBalpha kinase , JNK , [Akt] and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation . Positive_regulation AKT2 TNF 16924232 1692179 induced [Akt] *activation* needed for IKK activation was also abolished by deletion of PKR . Positive_regulation AKT2 TNF 16981137 1617031 *induced* the phosphorylation of [Akt] depending upon time . Positive_regulation AKT2 TNF 16981137 1617038 The phosphorylation of [Akt] *induced* by was markedly attenuated by LY294002 and wortmannin , inhibitors of PI3-kinase . Positive_regulation AKT2 TNF 16981137 1617042 PD98059 , a specific inhibitor of MEK , had little effect on the *induced* phosphorylation of [Akt] . Positive_regulation AKT2 TNF 17114809 1677180 In contrast , *stimulated* [Akt] phosphorylation , which was also required for DNA synthesis , was attenuated by SphK inhibition or SphK1 knockdown by small interfering RNA . Positive_regulation AKT2 TNF 17158207 1694186 Western blot analysis of L6 cell lysates demonstrated impaired insulin stimulated phosphorylation of [Akt] , serine/arginine-rich protein 40 , and glycogen synthase kinase 3beta in *response* to and the short chain C6 ceramide analog . Positive_regulation AKT2 TNF 17158602 1701117 In human tracheal smooth muscle cells , *induced* MMP-9 expression and [Akt] phosphorylation in a time dependent manner , which was attenuated by the inhibitors of Src ( PP1 ) , epidermal growth factor receptor ( AG1478 ) , PDGFR ( AG1296 ) , and PI3K ( LY294002 ) , respectively , revealed by reporter gene assay , RT-PCR , zymographic , and Western blot analyses . Positive_regulation AKT2 TNF 17158602 1701145 Thus , our study provides a new insight into the molecular mechanisms that *stimulated* [Akt] phosphorylation mediated through transactivation of Src and growth factor receptors may stimulate the recruitment of p300 , assemble transcription factor (p65) , and then lead to MMP-9 expression . Positive_regulation AKT2 TNF 17369858 1777761 Distinctive role of integrin mediated adhesion in *induced* [PKB/Akt] and NF-kappaB activation and endothelial cell survival . Positive_regulation AKT2 TNF 17369858 1777765 Taken together , these observations reveal a novel permissive role for integrins in induced [PKB/Akt] *activation* and prevention of TNF induced death distinct of NF-kappaB , and implicate the actin cytoskeleton in PKB/Akt mediated cell survival . Positive_regulation AKT2 TNF 17640567 1771202 Similarly , suppression of induced [AKT] *activation* by curcumin was also abrogated by glutathione . Positive_regulation AKT2 TNF 17971516 1859768 *induced* phosphorylation of [Akt] , and ERK1/2 was inhibited by an antibody against TNF-alpha receptor 1 (TNF-R1) . Positive_regulation AKT2 TNF 17971516 1859774 LY-294002 completely abolished *induced* stimulation of PS as well as phosphorylation of [Akt] and its downstream targets GSK-3 , p70 ( S6K ) , and 4E-BP1 . Positive_regulation AKT2 TNF 17994109 1851154 triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 MAPK , ERK 1/2 , SAPK/JNK and [Akt] activation , while increasing proliferation and migration . Positive_regulation AKT2 TNF 18091748 1847361 *induced* phosphorylation of extracellular signal regulated kinase ( ERK ) and [Akt] , but not p38 mitogen activated protein kinase (MAPK) , was attenuated by nicardipine , cilnidipine , benidipine , efonidipine , and azelnidipine . Positive_regulation AKT2 TNF 18180317 1856489 GLP-1 treatment also inhibited *mediated* induction of [Akt] phosphorylation . Positive_regulation AKT2 TNF 18227124 1895559 Moreover , *induced* [Akt] and CaM kinase II phosphorylation via cascades through Src/EGFR/PI3K and PLC/calcium/CaM , respectively . Positive_regulation AKT2 TNF 18273051 1931842 Here , we show that in normal keratinocytes and the transformed keratinocyte cell lines , HaCaT and A431 , *stimulates* protein kinase [B/Akt] , which results in activation of the survival complex mTORC1 ( mammalian target of rapamycin complex 1 ) and inhibition of the proapoptotic proteins Bad and FoxO3a . Positive_regulation AKT2 TNF 18287248 1896518 Flavopiridol suppresses induced *activation* of activator protein-1 , c-Jun N-terminal kinase , p38 mitogen activated protein kinase (MAPK) , p44/p42 MAPK , and [Akt] , inhibits expression of antiapoptotic gene products , and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells . Positive_regulation AKT2 TNF 18287248 1896537 It is noteworthy that this flavone also suppressed induced *activation* of [Akt] , a cell survival kinase , and expression of various antiapoptotic proteins , such as IAP-1 , IAP-2 , XIAP , Bcl-2 , Bcl-xL , and TRAF-1 . Positive_regulation AKT2 TNF 18490760 1917060 , in most cells examined , *activates* [Akt] to use IKKalpha to control mTOR activation . Positive_regulation AKT2 TNF 18490760 1917063 In MCF7 cells , does not *activate* [Akt] and requires IKKbeta to activate mTOR . Positive_regulation AKT2 TNF 18557926 1984195 We have recently shown that induced [Akt] *activation* may promote the early stages of skin cancer . Positive_regulation AKT2 TNF 18557926 1984199 In this work , we demonstrate that in the premalignant keratinocyte cell line HaCaT , *activates* [Akt] , ERK1/2 and p38 . Positive_regulation AKT2 TNF 18557926 1984203 The *dependent* phosphorylation of [Akt-ERK1/2] was slightly decreased by NF kappaB inhibition and in the presence of p38 blockers . Positive_regulation AKT2 TNF 18632801 1972583 also *caused* [PI3-kinase/Akt] activation , which was further increased by PDTC and prevented by the PI3-kinase inhibitor , LY294002 . Positive_regulation AKT2 TNF 19234337 2079527 However , *induced* [Akt] phosphorylation was blocked , and inhibiting Akt dramatically decreased CCL2 production . Positive_regulation AKT2 TNF 19275968 2072838 *stimulated* the phosphorylation levels of p38 MAPK , JNK , ERK1/2 and [Akt] in vascular endothelial cells . Positive_regulation AKT2 TNF 19404960 2075180 Inhibition of Mcl-1 by EGCG triggered caspase 3 activity in RA synovial fibroblasts , which was mediated via down-regulation of the *induced* [Akt] and NF-kappaB pathways . Positive_regulation AKT2 TNF 19760502 2264285 Moreover , *promoted* ErbB-2/ErbB-3 heterocomplex formation , [Akt] activation and NF-kappaB transcriptional activation . Positive_regulation AKT2 TNF 19879324 2197035 Rapamycin enhanced the IL-6 synthesis and the phosphorylation of [Akt] *induced* by also in human osteoblasts . Positive_regulation AKT2 TNF 20082310 2212577 *increased* the FAK , PI3K , and [Akt] phosphorylation . Positive_regulation AKT2 TNF 20135642 2235886 also *increased* the [Akt] and mTOR phosphorylation . Positive_regulation AKT2 TNF 20237236 2259889 *caused* activation of NF-kappaB , MAP kinases , and [PI3K-Akt] in podocytes , whereas blockade of these molecules did not affect inhibition of RAR by TNF-alpha . Positive_regulation AKT2 TNF 20333651 2266138 On the other hand , *stimulated* the phosphorylation of c-Src , EGFR , [Akt] , JNK1/2 , and c-Jun , which were inhibited by pretreatment with Gö6983 . Positive_regulation AKT2 TNF 20333651 2266151 We also showed that *induced* Akt translocation and the formation of an [Akt/p65/p300] complex . Positive_regulation AKT2 TNF 20562516 2290157 NAC also inhibited *induced* phosphorylation of [Akt] and NF-kappaB . Positive_regulation AKT2 TNF 20562516 2290164 W-7 and KN93 inhibited *induced* phosphorylation of [Akt] but not NF-kappaB . Positive_regulation AKT2 TNF 20732383 2363474 Wnt3a failed to affect the *induced* phosphorylation of p44/p42 MAP kinase , [Akt] , I?B or NF?B . Positive_regulation AKT2 TNF 20836895 2325630 LY294002 blocked *induced* phosphorylation of [Akt] and reduced the phosphorylation of both I?B-a and NF-?B . Positive_regulation AKT2 TNF 20937376 2375763 Three compounds all dose-dependently increased not only PPAR-? expression in EA.hy926 cells but inhibited *induced* phosphorylation of [Akt] , extracellular-signal regulated kinase ( ERK ) and protein kinase C ( PKC ) with different specificity . Positive_regulation AKT2 TNF 21040686 2339112 *activated* the protein kinase [B/Akt] and regulation of its downstream targets , mTOR , Bad and FoxO3a . Positive_regulation AKT2 TNF 21285293 2425712 Inhibitors of NADPH oxidase and/or p47phox siRNA diminished ROS production and COX-2 expression as well as phosphorylation of p38 mitogen activated protein kinase ( p38MAPK ) and [Akt] *mediated* either by AS serum or by . Positive_regulation AKT2 TNF 21300786 2403644 In addition to this effect , SubAB depressed basal and *induced* phosphorylation of [Akt] via the UPR . Positive_regulation AKT2 TNF 21344491 2415382 Consistently , treatment of HeLa cells with the compound significantly suppressed *induced* activation of [Akt] and phosphorylation of Ser536 in RelA/p65 , which is required for transactivation activity . Positive_regulation AKT2 TNF 21427355 2412169 In contrast to S6K1 , depletion of S6K2 by siRNA decreased basal and *induced* [Akt] phosphorylation . Positive_regulation AKT2 TNF 21545687 2554374 significantly *induced* phosphorylation of p38 MAPK , ERK , [Akt] and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation AKT2 TNF 21704193 2494338 3,4,5-Tricaffeoylquinic acid , Bay 11-7085 , Akt inhibitor and N-acetylcysteine inhibited the induced *activation* of NF-?B , activation of [Akt] , and formation of reactive oxygen and nitrogen species . Positive_regulation AKT2 TNF 21705614 2465727 Furthermore , luteolin inhibited *induced* phosphorylation of mitogen activated protein kinase/extracellular signal regulated kinase ( ERK ) kinase 1/ERK/p90 ( RSK ) , mitogen activated protein kinase kinase 4/c-Jun N-terminal kinase/c-Jun , and [Akt/p70] ( S6K ) . Positive_regulation AKT2 TNF 21856755 2473278 In addition , *induced* phosphorylation of extracellular signal regulated kinase , nuclear factor kappa B ( NF-?B ) and [Akt] in a time dependent manner , and increased nuclear translocation and promoter activity of NF-?B . Positive_regulation AKT2 TNF 21860594 2469242 Genipin dose- and time-dependently increased PPAR-? expression and inhibited *induced* phosphorylation of [Akt] and PKC with different degrees . Positive_regulation AKT2 TNF 22026410 2513648 Moreover , 1 abolished *induced* [Akt] phosphorylation . Positive_regulation AKT2 TNF 22433439 2588329 The use of inhibitors that block individual PI3K isoforms , including the novel selective PI3Kd inhibitor INK007 , showed that PI3Kd is required for PDGF- and *induced* [Akt] activation . Positive_regulation AKT2 TNF 22556157 2675440 LY294002 and wortmannin inhibited *induced* [Akt] activation , whereas only LY294002 inhibited CD38 expression . Positive_regulation AKT2 TNF 22561121 2608677 Zaprinast was found to activate ERK1/2 , p38 MAPK , JNK , NF?B , and [PI3K/Akt] , and subsequently , *induce* the mRNA expressions of IL-1a , IL-1ß , , CCL2 , CCL4 , CXCL1 , CXCL2 , and CD14 . Positive_regulation AKT2 TNF 22683933 2626480 Moreover , PA inhibited the *induced* phosphorylation of [AKT] , but not c-Jun N-terminal kinase , indicating that inhibition of survival signaling pathways activated by TNF-a may explain the effects of PA on TNF-a induced cytotoxicity . Positive_regulation AKT2 TNF 23243069 2757877 The inhibition of iTreg differentiation by TNF-a is mediated through a signaling cascade involving the induction of expression and the *activation* of [Akt] . Positive_regulation AKT2 TNF 23243069 2757880 Interestingly , this regulatory pathway is iTreg cell specific as does not *activate* [Akt] in naturally occurring regulatory T cells , therefore conferring a selective effect of TNF-a and its antagonism on iTreg cells . Positive_regulation AKT2 TNF 23328930 2798707 Immunofluorescence staining showed that alone *increased* the production of [P-Akt] , whereas LY294002 and 50 µM resveratrol suppressed the TNF-a stimulated expression of P-Akt . Positive_regulation AKT2 TNF 23333920 2758378 Interestingly , IL-27 promoted the basal and enhanced *induced* phosphorylation of p38 MAPK and [Akt] , but not I?Ba . Positive_regulation AKT2 TNF 23353699 2754233 In addition , *stimulated* [Akt] phosphorylation was inhibited by PP1 , AG1478 , AG1296 , or LY294002 . Positive_regulation AKT2 TNF 23632129 2790729 LAR also enhanced *induced* phospho-p38 and [phospho-AKT] expression , but inhibited the expression of phospho-JNK and nuclear translocation of NF-?Bp65 in RA synovial fibroblasts . Positive_regulation AKT2 TNF 23699531 2792337 Recombinant PGRN or transfection of a cDNA encoding PGRN did not antagonize *dependent* NF?B , [Akt] , and Erk1/2 pathway activation ; Positive_regulation AKT2 TNF 23710745 2792801 also significantly *activated* the phosphorylation of PTEN , [AKT] and FOXO3a ( P < 0.05 ) . Positive_regulation AKT2 TNF 24151609 2859753 In our study , we found that a treatments *induce* MEK and [AKT] phosphorylation . Positive_regulation AKT2 TNF 24361597 2911238 *stimulated* [Akt] phosphorylation was inhibited by genistein , PP1 , AG1296 , LY294002 , or SH5 . Positive_regulation AKT2 TNF 24441870 2922926 We showed that markedly *stimulated* Jak2 , PDGFR , [Akt] , and p42/p44 MAPK phosphorylation , which were attenuated by their respective inhibitors . Positive_regulation AKT2 TNF 24441870 2922942 Moreover , *stimulated* [Akt] activation via a Jak2/PDGFR pathway in HPAEpiCs . Positive_regulation AKT2 TNF 24441870 2922981 On the other hand , could *induce* [Akt] and p42/p44 MAPK translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation AKT2 TNFSF10 11992615 938784 In addition , combined and wortmannin treatment *resulted* in cleavage of several proteins : PARP , [Akt] , p21/WAF1 , and MDM2 as well as dephosphorylation of Akt . Positive_regulation AKT2 TNFSF10 12668516 1085981 *activated* the protein kinase [Akt] in HUVECs , as assessed by Western blot for phospho-Akt . Positive_regulation AKT2 TNFSF10 12807432 1101893 rapidly ( from 20 min ) *induced* the phosphorylation of [Akt] and ERK , but not of c-Jun NH2-terminal kinase (JNK) . Positive_regulation AKT2 TNFSF10 15289937 1278542 Western blot analysis consistently showed that *induced* a significant activation of ERK1/2 , and a much weaker phosphorylation of [Akt] , while it did not affect the p38/MAPK pathway . Positive_regulation AKT2 TNFSF10 15711939 1373705 Conversely , *induced* caspase dependent cleavage of [Akt] neutralizing its anti-apoptotic effects . Positive_regulation AKT2 TNFSF10 17595512 1764778 *induced* the phosphorylation of ERK1/2 , but not of [Akt] . Positive_regulation AKT2 TNFSF10 19573813 2104765 Src *mediates* [AKT] regulation and cancer cell survival responses to CXCL12 and ( TRAIL ) , factors that are distinctively expressed in the bone metastasis microenvironment . Positive_regulation AKT2 TNFSF10 19861161 2184426 Data from gene knockdown experiments with an RNA interference ( RNAi ) technique show that c-Cbl is involved in the interaction between Src and PI3K p85 during TRAIL treatment , playing an important role in *induced* [Akt] phosphorylation . Positive_regulation AKT2 TNFSF10 20149311 2179052 Notably , CaMKII chemical inhibitor abrogated *induced* phosphorylation of [Akt] . Positive_regulation AKT2 TNFSF10 20400979 2273977 Ovarian cancer ascites protects from induced cell death through alphavbeta5 integrin mediated focal adhesion kinase and [Akt] *activation* . Positive_regulation AKT2 TNFSF10 21109947 2366261 Akt catalytic activation is known to increase during metabolic oxidative stress , but we show that also dramatically *induces* the catalytic activation of [Akt] in TRAIL-sensitive cells , but not in TRAIL-resistant cells . Positive_regulation AKT2 TNFSF10 21472268 2361572 Further investigation revealed that engagement *led* to the activation of [PI3K/Akt] as well as of NF-?B . Positive_regulation AKT2 TNFSF10 21472268 2361582 Our data demonstrated that the *activation* of [PI3K/Akt] and NF-?B by is responsible for resistance to TRAIL in human gastric cancer cells . Positive_regulation AKT2 TNFSF10 23408429 2759799 Mechanically , MTDH down-regulated caspase-8 , decreased caspase-8 recruitment into the TRAIL death inducing signaling complex , decreased caspase-3 and poly(ADP-ribose) polymerase-2 processing , increased Bcl-2 expression , and stimulated *induced* [Akt] phosphorylation , without altering death receptor status . Positive_regulation AKT2 TNFSF10 24308965 2904860 HSP27 phosphorylation modulates *induced* activation of [Src-Akt/ERK] signaling through interaction with ß-arrestin2 . Positive_regulation AKT2 TNFSF10 24308965 2904864 In addition , reduced HSP27 phosphorylation by KRIBB3 treatment or MK2 knockdown attenuated the *induced* activation of [Akt] and ERK survival signaling through suppressing the phosphorylation of Src . Positive_regulation AKT3 ANGPT1 10585289 571136 Ceramide induced endothelial cell death and abolished mediated *activation* of [Akt] and the effect on cell survival . Positive_regulation AKT3 ANGPT1 10625301 658525 *induced* phosphorylation of the serine-threonine kinase [Akt] at Ser473 in a PI 3'-kinase dependent manner . Positive_regulation AKT3 ANGPT1 12514118 1063781 Treatment of cells with the phosphatidyl-inositol 3-kinase (PI3-K) inhibitor , LY294002 , inhibited *induced* phosphorylation of [Akt] , restored the cleavage of the effector caspase-3 , and reduced the protective effect of Ang-1 against SD-induced toxicity . Positive_regulation AKT3 ANGPT1 16000309 1452801 These data suggested that *dependent* [Akt] phosphorylation through PI 3-kinase leads to the inhibition of JNK phosphorylation . Positive_regulation AKT3 ANGPT1 16679392 1612147 Pretreatment with either DPI or apocynin also significantly attenuated *induced* [Akt] and p44/42 MAPK phosphorylation . Positive_regulation AKT3 ANGPT1 16679392 1612163 Using mouse heart microvascular endothelial cells from wild-type ( WT ) mice and mice deficient in the p47(phox) component of NADPH oxidase ( p47 ( phox-/- ) ) , we found that although *stimulated* intracellular ROS , [Akt] and p42/44 MAPK phosphorylation , and cell migration in WT cells , the responses were strikingly suppressed in cells from the p47 ( phox-/- ) mice . Positive_regulation AKT3 ANGPT1 17965739 1831102 On the other hand , C-18 blocked activation of members of the mitogen activated protein kinase family and of the Ser/Thr kinase [Akt] *induced* by both VEGF and . Positive_regulation AKT3 ANGPT1 18556567 1946040 These alterations led to a significant impairment of *induced* [Akt] and eNOS phosphorylation , along with a remarkable impairment of Ang-1 induced endothelial cell migration and endothelial cell spheroid sprouting . Positive_regulation AKT3 ANGPT1 18565279 1929502 *induced* [Akt] phosphorylation , increased the Bcl-2/Bax ratio , and decreased the activation of caspase-9 and -3 . Positive_regulation AKT3 ANGPT1 19037734 2001602 ANG9-4 blocked mediated Tie2 phosphorylation and downstream [Akt] *activation* . Positive_regulation AKT3 ANGPT1 19615361 2124099 Treatment of HUVECs with the lipid raft disrupting agent methyl-beta-cyclodextrin selectively inhibited *induced* [Akt] phosphorylation , but not Erk1/2 phosphorylation . Positive_regulation AKT3 ANGPT1 20056911 2218425 A soluble form of Tie-2 produced in human umbilical vein endothelial cells was dramatically suppressed by treatment with siRNA-matrix metalloproteinase (MMP) 14 or tissue inhibitor of metalloproteinase 3 , resulting in an increase in cellular fTie-2 and thereby enhancing *dependent* [Akt] phosphorylation and Akt dependent endothelial functions , such as Ang-2 downregulation or an increase of endothelial viability . Positive_regulation AKT3 ANGPT1 20079751 2212517 Examination of downstream signaling revealed inhibition of *dependent* [Akt] phosphorylation . Positive_regulation AKT3 ANGPT1 20079751 2212522 Similar suppression of *dependent* activation of [Akt] by hyperglycemia was observed in large vessel human endothelial cells . Positive_regulation AKT3 ANGPT1 20079751 2212528 Incubation of microvascular endothelial cells with 200 microM palmitic acid significantly inhibited *dependent* [Akt] phosphorylation without affecting phosphorylation of the Tie-2 receptor or of ERK1/2 . Positive_regulation AKT3 ANGPT1 20519501 2289602 However , only *induces* Tie2 dependent [Akt] activation and subsequent survival signaling and endothelial quiescence . Positive_regulation AKT3 ARSA 20640495 2360389 Both SIM and DIP+low-dose *augmented* [Akt] phosphorylation and their effect was additive . Positive_regulation AKT3 BPI 17012258 1629181 , but not control protein thaumatin , *activated* extracellular regulated kinase (ERK) and [AKT] , and increased DNA synthesis in RPE and RPC but not in REC . Positive_regulation AKT3 BPI 18055828 1833397 The authors recently reported that can *induce* ERK1/2 and [Akt] activity and that it increases DNA synthesis in the bovine retinal pigment epithelial (RPE) and pericyte cells . Positive_regulation AKT3 BPI 18055828 1833402 Heparitinase , phosphatidylinositol-specific phospholipase C , and anti-GPC4 antibody suppressed *induced* ERK and [Akt] phosphorylation in bovine RPE . Positive_regulation AKT3 BPI 23740083 2807056 In addition , can inhibit angiogenesis , suppress LPS mediated platelet activation , increase DNA synthesis , and *activate* [ERK/Akt] signaling . Positive_regulation AKT3 C12orf75 22935015 2740239 binds with insulin receptor substrate 4 and *increases* insulin stimulated [phospho-Akt] and regulates AMP activated protein kinase and mammalian target of rapamycin downstream target S6 kinase phosphorylation . Positive_regulation AKT3 CAPN8 23071514 2685972 Pro-death activity of violacein is actually carried out by inhibition of and DAPK1 and *activation* of PKA , [AKT] and PDK , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation AKT3 CAPN8 23455548 2781788 Blocking AKT further increased doxorubicin induced cardiac injuries , suggesting the effects of inhibition may be *mediated* by inactivating the [AKT] signalling . Positive_regulation AKT3 CAPN8 23467348 2750087 BDNF treatment increased phosphorylation of both Akt and ERK , but only the effect on [Akt] was *blocked* by inhibition . Positive_regulation AKT3 CCND1 19114984 2031800 PTK/ZK also induced cell cycle arrest , accompanied by increasing the expression of p27 ( Kip1 ) and downregulation of and cyclin E. PTK/ZK significantly *inhibited* vascular endothelial growth factor ( VEGF ) expression , as well as VEGF simulated cell proliferation and phosphorylation of [Akt] in activated HSCs . Positive_regulation AKT3 CCND1 19935697 2210096 The expression of *required* both EGFR mediated ERK and [AKT] activation . Positive_regulation AKT3 CCND1 22579115 2609552 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated and Cyclin B1 proteins as well as *activation* of [PI3K/Akt] and Raf/MEK/ERK , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation AKT3 CCND1 24737397 2943106 Mechanistically , aberrant PRL-3 expression promoted cell cycle progression and enhanced the antiapoptotic machinery of AML cells to drug cytotoxicity through downregulation of p21 and upregulation of and CDK2 and *activation* of STAT5 and [AKT] . Positive_regulation AKT3 CD14 22561121 2608683 Zaprinast was found to activate ERK1/2 , p38 MAPK , JNK , NF?B , and [PI3K/Akt] , and subsequently , *induce* the mRNA expressions of IL-1a , IL-1ß , TNF-a , CCL2 , CCL4 , CXCL1 , CXCL2 , and . Positive_regulation AKT3 CEACAM6 18159236 1838557 The colonocyte surface level of integrin alpha5 and the activation of [AKT] *increased* progressively with the expression levels of . Positive_regulation AKT3 CEACAM6 18614350 1947298 Suppression of expression using small interfering RNA ( siRNA ) completely reversed migration and invasion of MCF-7 : 5C and MCF-7 : 2A cells and it significantly *reduced* phosphorylated [Akt] and c-Src expression in these cells . Positive_regulation AKT3 CHI3L1 23972995 2836234 We also demonstrate that *activates* macrophage mitogen activated protein kinase , protein kinase [B/AKT] , and Wnt/ß-catenin signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation AKT3 CLU 21270507 2387621 The protective effect of clusterin on H2O2 induced apoptosis is impaired by PI3K inhibitor LY294002 , which effectively suppresses induced *activation* of [Akt] and GSK-3ß . Positive_regulation AKT3 CLU 22012253 2498764 Secreted , which is selectively increased after transformation , *activates* the survival factor [AKT] , whereas intracellular CLU inhibits the activity of the oncogenic transcription factor nuclear factor kappa B . Positive_regulation AKT3 CLU 24569077 2924724 The phosphorylation of [Akt] *induced* by was blocked by pretreatment with gallein or LY294002 but not with U73122 , indicating that Gß? released from the PTX-sensitive Gi protein complex activated PLC and PI3K/Akt signaling pathways separately . Positive_regulation AKT3 CTGF 16408113 1513472 *enhanced* the mRNA expression and protein release of fractalkine , MCP-1 , and RANTES , the expression of phospho ( P ) -p42/44 mitogen activated protein kinase (MAPK) , P-phosphoinositide 3-kinase (PI3-K) , [P-Akt] , and activity of nuclear factor-kappaB (NF-kappaB) in mesangial cells . Positive_regulation AKT3 CTGF 16408113 1513531 P-PI3-K blockade downregulated the *stimulated* expression of P-PI3-K , [P-Akt] , and NF-kappaB but not P-p42/44 MAPK , and partially decreased the release of the above chemokines . Positive_regulation AKT3 CTGF 16408113 1513540 LXA ( 4 ) dose-dependently inhibited the *stimulated* mRNA expression and protein release of the above chemokines , and the expression of P-p42/44MAPK , P-PI3-K , [P-Akt] , and NF-kappaB . Positive_regulation AKT3 CTGF 16877704 1600905 Most interestingly , overexpression of *suppressed* insulin-like growth factor-I dependent [Akt] phosphorylation and epidermal growth factor dependent extracellular signal regulated kinase 1/2 phosphorylation . Positive_regulation AKT3 CTGF 18375200 1899009 *induces* cardiac hypertrophy through [Akt] signaling . Positive_regulation AKT3 CTGF 20213804 2249222 *induced* phosphorylation of p38 , ERK-1/2 , JNK , and [Akt] , but not Smad3 , in transgenic mouse fibroblasts compared with wild-type mouse fibroblasts . Positive_regulation AKT3 CTGF 22363445 2561522 induced PDGF-B expression in endothelial cells , and *potentiated* PDGF-B mediated [Akt] signaling in mural ( vascular smooth muscle/pericyte ) cells . Positive_regulation AKT3 CTGF 23208610 2745466 Concentration-effect experiments revealed CCN2 stimulated phosphorylation of Akt ( Ser473 ) and downstream GSK-3ß ( Ser9 ) with EC50 ~250 nmol/L. *stimulated* phosphorylation of [Akt] and GSK-3ß was sensitive to inhibition of PI3-kinase ( LY294002 ) . Positive_regulation AKT3 DAPK1 23071514 2685976 Pro-death activity of violacein is actually carried out by inhibition of calpain and and *activation* of PKA , [AKT] and PDK , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation AKT3 EDN2 15860794 1425751 Both MBP1 and *induced* phosphorylation of [Akt] , but with divergent time courses and intensities , and survival was independent of Akt . Positive_regulation AKT3 EPHB2 11306698 804284 These results demonstrated that t-BHQ activated PI3-kinase and [Akt] , which was responsible for ARE mediated rGSTA2 induction , and that might negatively *regulate* rGSTA2 expression , whereas activation of p38 MAP kinase or of JNK by t-BHQ was not associated with the enzyme induction . Positive_regulation AKT3 EPHB2 11445578 850514 Finally , examination of the phosphorylation state of Akt after HGF stimulation revealed that inhibition *resulted* in a decrease in [Akt] activation at both 5 and 10 min . Positive_regulation AKT3 EPHB2 11454948 837878 Inhibition of [Akt] activation *required* almost complete inhibition of . Positive_regulation AKT3 EPHB2 12034359 948255 C ( 2 ) -ceramide induced a delayed activation of ( > 1 h ) and a much later *activation* of [Akt/PKB] ( > 3 h ) in human melanocytes . Positive_regulation AKT3 EPHB2 12138095 991545 Cell survival relied on two pertussis toxin-sensitive events , activation of and *activation* of phosphatidylinositol 3-kinase [(PI3K)/Akt] by S1P . Positive_regulation AKT3 EPHB2 12727858 1086463 In contrast , phosphorylation of [AKT] is *dependent* on and C-SRC activity . Positive_regulation AKT3 EPHB2 14996702 1257043 Surprisingly , phosphoinositide-3 (PI-3) kinase inhibitors block not only [PKB/Akt] activation but also *activation* of Raf and . Positive_regulation AKT3 EPHB2 15242975 1282059 when PI3K was inhibited , phosphorylation could be *induced* by microinjected activated [Akt] , indicating important cross-talk between the PI3K and ERK1/2 pathways . Positive_regulation AKT3 EPHB2 15344880 1292097 In these R- cells , PI3K inhibition by LY294002 enhanced insulin stimulation of phosphorylation whereas LY294002 *inhibited* insulin stimulation of [Akt] phosphorylation . Positive_regulation AKT3 EPHB2 15360086 1293609 The Hsp90 chaperone complex inhibitor , radicicol , potentiated heat induced cellular killing , and inhibition of p42/p44 and [Akt] *activation* rather than modification of Hsp expression might be involved in enhancing cellular thermosensitivity . Positive_regulation AKT3 EPHB2 15607817 1357048 Furthermore , U0126 and LY294002 , which respectively inhibit MEK *induced* phosphorylation and PI3 kinase mediated [Akt] phosphorylation had distinct effects on C3a induced responses . Positive_regulation AKT3 EPHB2 15767555 1384174 These events were associated with marked down-regulation of Raf-1 , MEK , and phosphorylation , diminished [Akt] *activation* , and enhanced phosphorylation of c-Jun NH2-terminal kinase (JNK) . Positive_regulation AKT3 EPHB2 15976193 1441142 Concurrent with p53 activation , DON activated two anti-apoptotic survival pathways as evidenced by both dependent p90 Rsk and [AKT] *activation* . Positive_regulation AKT3 EPHB2 16782756 1625025 Taken together , these data demonstrate that mtALDH overexpression attenuates hyperoxia induced cell death in lung epithelial cells through reduction of ROS , *activation* of , and [PI3K-Akt] cell survival signaling pathways . Positive_regulation AKT3 EPHB2 16877565 1638822 However , inhibitors of Raf-1 and MEK or a dominant negative mutant *blocked* FKN induced ERK , but not [Akt] and eNOS , phosphorylation . Positive_regulation AKT3 EPHB2 16954211 1633349 Under basal conditions , dopamine transporter knock-out mice show enhanced striatal DARPP-32 phosphorylation , *activation* of , and inactivation of [Akt] as compared with wild-type littermates . Positive_regulation AKT3 EPHB2 17433443 1736813 In cytokine producing Jurkat T cells , we have found that IL-4 induces activation of Erk and [Akt] , and the IL-4 induced STAT6 activity is *suppressed* by inhibitors of and PI3K . Positive_regulation AKT3 EPHB2 17540722 1778454 inhibitor PD98059 *inhibited* the PI3K activity , [Akt] phosphorylation , and lipid accumulation triggered by HG . Positive_regulation AKT3 EPHB2 17634416 1793045 These findings suggest that ouabain stimulated phosphorylation is *required* for [Akt] phosphorylation on Ser ( 473 ) , cell proliferation , and stimulation of Na ( + ) /K ( + ) -ATPase mediated ( 86 ) Rb uptake in OK cells . Positive_regulation AKT3 EPHB2 17804197 1810127 In this study , we demonstrate that Wnt5a specifically binds to Fzd3 in vitro and triggers phosphorylation of [Akt] *mediated* by phosphatidylinositol-3 kinase (PI3K) , but not that of or protein kinase C , in human primary cultured dermal fibroblasts . Positive_regulation AKT3 EPHB2 18310510 1904185 HG induces phosphoinositide 3- kinase [ PI3K ; inhibited by adenoviral ( Ad ) .dominant negative ( dn ) PI3Kp85 ] , Akt ( inhibited by Ad.dnAkt1 ) , and ( inhibited by PD-98059 ) activation and *induces* IL-17 expression via PI3K -- > [Akt] -- > ERK dependent signaling . Positive_regulation AKT3 EPHB2 18340449 1932024 Using chondrosarcoma cells stimulated with IL-1beta , the effects of GLN on the mRNA and protein levels of MMP-3 , the *activation* of JNK , , p38 , NF-kappaB , and AP-1 , the nuclear translocation of NF-kappaB/Rel family members , and [PI3-kinase/Akt] activation were studied . Positive_regulation AKT3 EPHB2 18509361 1971901 In a univariate analysis , shorter overall survival was associated with the presence of ulceration ( P=0.001 ) and BRAF exon 15 mutations ( P=0.005 ) as well as the absence of nuclear activation of [Akt] ( P=0.022 ) and of cytoplasmic *activation* of ( P=0.003 ) . Positive_regulation AKT3 EPHB2 19424594 2076406 Here , we showed that long-term ER stress resulted in inactivation of [Akt] and *activation* of in human hepatocellular carcinoma ( HCC ) cells . Positive_regulation AKT3 EPHB2 20177738 2272389 These observations indicate that Cbl-b promotes RBL-2H3 apoptosis induced by VP-16 or Ara-c , probably through inhibition of [Akt] and *activation* of . Positive_regulation AKT3 EPHB2 20668435 2317126 In addition , DHA caused [AKT] and ERK activation in a time dependent manner , and the DHA induced HO-1 upregulation could be *attenuated* by PI-3 kinase/AKT and inhibitors . Positive_regulation AKT3 EPHB2 21889928 2496511 In addition , lonidamine elicits and [Akt/mTOR] pathway *activation* , as indicated by increased ERK , Akt , p70S6K and rpS6 phosphorylation , and these effects are reduced by co-treatment with ATO . Positive_regulation AKT3 EPHB2 22039307 2508199 receptors *trigger* [Akt] activation and suppress Fas receptor induced apoptosis in malignant T lymphocytes . Positive_regulation AKT3 EPHB2 22964641 2827263 In defining each pathway 's contributions , we found that [AKT] inhibition alone maximally *induced* GAPDH nuclear accumulation , whereas inhibition alone had no effect on GAPDH localization . Positive_regulation AKT3 EPHB2 23087613 2690472 When analyzing possible signaling mechanisms we found that extracellular signal regulated kinase ( ERK ) and [Akt] are activated by C3 ( bot ) and is *induced* by the C3 ( E174Q ) mutant . Positive_regulation AKT3 EPHB2 23276632 2775375 Furthermore , E2 rapidly enhanced ERK and [Akt] activation in cortical neurons , and inhibitors of and Akt activation significantly *attenuated* E2 induction of excitatory glutamatergic synapses . Positive_regulation AKT3 EPHB2 23715867 2811534 a-Lipoic acid *enhanced* [Akt] phosphorylation and decreased ERK and JNK phosphorylation , whereas a-tocopherol enhanced and JNK phosphorylation but had little effect on Akt phosphorylation . Positive_regulation AKT3 EPHB2 24212072 2891979 Our results seem that inhibition of [Akt] and *activation* of or p38 MAPK may lead to the suppression of melanogenesis in eupafolin treated B16F10 mouse melanoma cells . Positive_regulation AKT3 EPHB2 24239652 2897703 Specifically , HA-induced NF-?B activation was mediated by ROS and [AKT] , and that HA-induced AP-1 activation was *mediated* by JNK and . Positive_regulation AKT3 EPHB2 24316039 2899363 We found that lifespan extension induced by cranberry was associated with reduced phosphorylation of , a component of oxidative stress response MAPK signaling , and slightly *increased* phosphorylation of [AKT] , a component of insulin-like signaling . Positive_regulation AKT3 EPHB2 24345501 2880902 TNF-a stimulated significantly phosphorylation on Ser536 of NF-?B/p65 , Ser473 of [Akt] at 5-15 min , and *activations* of IKK-ß and at 15-30 min. Diosgenin ( 1 µmol · Positive_regulation AKT3 EPHB2 24424889 2901250 Taken together , these findings suggest that MHY-449 induces apoptosis via downregulation of the [Akt/FoxO1] and *activation* of in androgen independent , p53-null and PTEN negative PC3 human prostate cancer cells . Positive_regulation AKT3 EPHB2 24530412 2924305 It is noteworthy that a tyrosine kinase receptor inhibitor , K252a , an inhibitor ( U0126 ) , and a PI3Kinase-Akt inhibitor ( LY294002 ) remarkably *attenuated* TrkB , ERK , and [Akt] phosphorylation as well as increase of OPN mRNA expression in the HCEM cells , respectively . Positive_regulation AKT3 EPHB2 24597762 2933803 Exposure of CGNs to GDF15 markedly induced the phosphorylation of ERK ( extracellular-signal regulated kinase ) , [Akt] and mTOR ( mammalian target of rapamycin ) , but the GDF15 induced IK densities and increased expression of Kv2.1 were *attenuated* only by Akt and mTOR , and not , inhibitors . Positive_regulation AKT3 EPHB2 24909280 2941803 in the LY294002 treatment group , the level of [p-AKT] protein decreased and *increased* ; Positive_regulation AKT3 F2R 19765562 2163533 In addition , [Akt] phosphorylation caused by plasmin was inhibited in the *presence* of inhibitor . Positive_regulation AKT3 F2R 24763028 2936959 It is concluded that thrombin can stimulate MSC proliferation by eliciting mediated [AKT] *activation* and subsequent up-regulation of c-MYC expression . Positive_regulation AKT3 FAS 14967838 1220245 signaling *induces* [Akt] activation and upregulation of endothelial nitric oxide synthase expression . Positive_regulation AKT3 FAS 14967838 1220257 Here , we report that engagement with Fas ligand *induced* activation of [Akt] and upregulation of endothelial nitric oxide synthase expression without induction of apoptosis . Positive_regulation AKT3 FAS 15665818 1369598 Additionally , [Akt] inhibition *induced* signaling was observed to link to the mitochondrial pathway via Bid cleavage . Positive_regulation AKT3 FAS 15806173 1417491 In contrast , inhibition of activity by the drug C75 *resulted* in downregulation of [phospho-AKT] and increased cell death . Positive_regulation AKT3 FAS 15806173 1417500 Furthermore , inhibition of activity by cerulenin or C75 *resulted* in downregulation of [phospho-AKT] , which preceded the induction of apoptosis . Positive_regulation AKT3 FAS 15982313 1424724 Using a variety of inhibitors and blocking antibodies , we demonstrated that : ( i ) apoptosis is required for the generation of the signal ( s ) leading to the activation of EGFR , ERK , and Akt; (ii) the activation of EGFR , ERK , and [Akt] by FasL is indeed *mediated* by its bona fide receptor ; Positive_regulation AKT3 FAS 19460632 2084806 omega3 also *restored* levels of cerebellar phospho ( p ) [-AKT] , phospho-extracellular regulated kinase ( p-ERK ) and phospho-c-Jun N-terminal kinase ( p-JNK ) , which were altered by hypothyroid insults , without interfering with the expression of TH responsive gene , myelin basic protein (mbp) . Positive_regulation AKT3 FAS 25086185 2956929 These data reveal a surprising sensitivity of K-Ras-driven cancer cells to suppression when stimulation of [Akt] and ERK was *prevented* . Positive_regulation AKT3 FGFBP1 17553847 1773833 At the molecular level , *enhanced* FGF2 induced protein tyrosine phosphorylation and [AKT/PKB] activation . Positive_regulation AKT3 FOXA1 22879989 2641677 An increase in IGFBP-3 , mediated by depletion of , *inhibited* phosphorylation of MAPK and [Akt] , and increased expression of the cell cycle regulators p21 and p27 . Positive_regulation AKT3 FOXO1 10358014 618638 These results suggest that may be a direct nuclear regulatory *target* for [Akt] in both metabolic and cell survival pathways . Positive_regulation AKT3 FOXO1 18077353 1836693 Here , we report that sustained activation of either or FoxO3 in cardiac myocytes *increases* basal levels of [Akt] phosphorylation and kinase activity . Positive_regulation AKT3 FOXO1 18077353 1836704 *activated* [Akt] directly interacts with and phosphorylates FoxO , providing feedback inhibition . Positive_regulation AKT3 FOXO1 18077353 1836805 Repression of Akt-PP2A/B interactions and phosphatase activities contributes , at least in part , to *dependent* increases in [Akt] phosphorylation and kinase activity . Positive_regulation AKT3 FOXO1 18077353 1836841 Importantly , *mediated* increases in [Akt] activity diminish insulin signaling , as manifested by reduced Akt phosphorylation , reduced membrane translocation of Glut4 , and decreased insulin triggered glucose uptake . Positive_regulation AKT3 FOXO1 18249169 1865235 A new study by Ni et al. ( 2007 ) shows that sustained activation of or FoxO3 in cardiomyocytes selectively *enhances* the activity of [Akt/PKB] and reduces insulin signaling through inhibition of calcineurin and PP2A . Positive_regulation AKT3 FOXO1 20709952 2312825 However , whereas the [PI(3)K/Akt] regulation of Rag transcription is *mediated* by , we show in this study that the MEK/ERK pathway coordinates with the regulation of Rag by controlling the phosphorylation and turnover of E47 and its consequential binding to the Rag enhancer regions . Positive_regulation AKT3 FOXO1 22068162 2528241 The effect of progranulin on proliferation and [Akt] *activation* and subsequent effects of phosphorylation were assessed in vitro . Positive_regulation AKT3 FOXO1 24424889 2901242 Furthermore , MHY-449 reduced the phosphorylation of [Akt] and FoxO1 and *induced* the translocation of from cytoplasm to nucleus as shown by western blot analysis . Positive_regulation AKT3 FOXO1 24874427 2945694 *mediated* activation of [Akt] plays a critical role in vascular homeostasis . Positive_regulation AKT3 FOXO1 24874427 2945701 Moreover , *mediated* feedback activation of [Akt] maintains growth factor responsive Akt/mTORC1 activity within a homeostatic range . Positive_regulation AKT3 FUT4 20506505 2307950 These data suggested that not only *activates* MAPK and [PI3K/Akt] signals , but also promotes the crosstalk among these signaling pathways . Positive_regulation AKT3 FUT4 21337384 2411175 The results showed that overexpression *up-regulated* phosphorylation of ERK1/2 and [Akt] which was inhibited by CPA in dose dependent manner . Positive_regulation AKT3 FUT4 23887626 2821550 Moreover , *induced* activation of phosphatidylinositol 3-kinase [(PI3K)/Akt] , and inactivation of GSK3ß and nuclear translocation of NF-?B , resulting in increased Snail and MMP-9 expression and greater cell motility . Positive_regulation AKT3 GLP1R 22182839 2537190 Transgene expression restored *dependent* stimulation of cAMP and [Akt] phosphorylation in isolated islets , conferred GLP-1R dependent stimulation of ß cell proliferation , and was sufficient for restoration of GLP-1 stimulated insulin secretion in perifused islets . Positive_regulation AKT3 GLP1R 23900416 2839800 Hindbrain mediated suppression of food intake *requires* a PI3K dependent decrease in phosphorylation of membrane bound [Akt] . Positive_regulation AKT3 GLP1R 24269940 2893115 Finally , GW exerted anti-apoptotic effects via interfering with *dependent* [Akt/Bcl-2] and Bcl-xl/caspase-3 signaling pathways . Positive_regulation AKT3 GPR115 17329974 1707176 [Akt/TSC/mTOR] *activation* by the KSHV : emerging insights into the molecular oncogenesis and treatment of Kaposi 's sarcoma . Positive_regulation AKT3 GPR115 17949438 1826044 *induced* [Akt] activity in cellular proliferation and apoptosis . Positive_regulation AKT3 GPR132 17329974 1707165 [Akt/TSC/mTOR] *activation* by the KSHV : emerging insights into the molecular oncogenesis and treatment of Kaposi 's sarcoma . Positive_regulation AKT3 GPR132 17949438 1826033 *induced* [Akt] activity in cellular proliferation and apoptosis . Positive_regulation AKT3 GPR87 17329974 1707245 [Akt/TSC/mTOR] *activation* by the KSHV : emerging insights into the molecular oncogenesis and treatment of Kaposi 's sarcoma . Positive_regulation AKT3 GPR87 17949438 1826113 *induced* [Akt] activity in cellular proliferation and apoptosis . Positive_regulation AKT3 HBEGF 11882602 919642 PD98059 inhibited HB-EGF induced ERK activation , whereas it had no effect on [Akt] *activation* by . Positive_regulation AKT3 HBEGF 15380451 1298475 *induced* phosphorylation of ERK , p38 MAPK and [Akt] , which were suppressed by ZD1839 . Positive_regulation AKT3 HBEGF 15952178 1440643 The phosphatidylinositol 3'-kinase (PI3K) inhibitors LY294002 and wortmannin , and the MAPK/extracellular signal regulated kinase ( ERK ) kinase ( MEK ) inhibitors U0126 and PD98059 , reduced HB-EGF induced BrdU incorporation into cultures , and *enhanced* phosphorylation of [Akt] and ERK , implying a role for PI3K/Akt and MEK/ERK signaling in HB-EGF stimulated cell proliferation . Positive_regulation AKT3 HBEGF 16034135 1436433 In this report , we show that in intestinal epithelial cells , *triggered* PI3K dependent phosphorylation of [Akt] . Positive_regulation AKT3 HBEGF 16799022 1579192 On the other hand , AKT phosphorylation was much more sensitive to PP2 than ERK or EGFR phosphorylation because 3.13 microM PP2 effectively inhibited wound- or *induced* [AKT] phosphorylation . Positive_regulation AKT3 HBEGF 19470173 2091042 The induced clustering of EGFR was observed minimally after 5 min of integrin crosslinking but was more prominent after 15 min . EGFR clustering had minimal effect on the phosphorylation of [Akt] or Erk1 ,2 in response to EGF in suspended cells or in *response* to in adherent cells . Positive_regulation AKT3 HBEGF 19559571 2110521 Finally , the induced *activation* of [Akt] and eNOS was suppressed by VEGF competitive antagonist , CBO-P11 . Positive_regulation AKT3 HBEGF 21289053 2410024 However , general metalloprotease inhibition , as well as specific inhibitors of ( HB-EGF ) , *prevented* both EGFR and downstream [Akt] activation . Positive_regulation AKT3 ID1 17855368 1818123 Furthermore , our results revealed that this effect was regulated by induced [Akt] *activation* through promoting the binding activity between Cav-1 and protein phosphatase 2A . Positive_regulation AKT3 ID1 19079342 2030882 *activates* [Akt] mediated Wnt signaling and p27 ( Kip1 ) phosphorylation through PTEN inhibition . Positive_regulation AKT3 IFI27 12768542 1094564 Second , ACTH-R triggers cAMP/PKA mediated antimitogenic mechanisms comprised of [Akt/PKB] dephosphorylation/deactivation , c-Myc protein degradation , and ( Kip1 ) protein *induction* . Positive_regulation AKT3 IFI27 19954644 2172455 Western blot results showed that the [Akt] phosphorylation and cyclin D1 expression was significantly decreased ( P < 0.01 ) , and the expression of ( KIP1 ) and p21 ( WAF1/CIPI ) *increased* . Positive_regulation AKT3 IL1B 11022128 738144 Furthermore , anti-inflammatory cytokines such as IL-4 and IL-10 that block IL-1b induced NFkappaB activation also attenuate *induced* [Akt] phosphorylation , despite the fact that IL-4 and IL-10 in isolation induced Akt phosphorylation . Positive_regulation AKT3 IL1B 11605009 871542 Pretreatment with SB203085 inhibited *induced* p38 and [AKT] phosphorylation . Positive_regulation AKT3 IL1B 11976320 953894 In human embryonic kidney 293 cells , *induces* IkappaB kinase beta (IKKbeta) activation , IkappaBalpha degradation , NF-kappaB transactivation , and weak [Akt] activation . Positive_regulation AKT3 IL1B 12126643 966022 P38 mitogen activated protein kinase (MAPK) was activated after 5min of IL-1beta treatment , whereas the extracellular signal regulated kinases , the c-jun amino-terminal kinases , and protein kinase [B/Akt] were not *activated* by . Positive_regulation AKT3 IL1B 12483539 1024812 Exogenous expression of either SHPS-1 mutants that lack SHP-2 binding function or a dominant negative mutant of SHP-2 markedly inhibited the *activation* of Erk 1/2 and [Akt] by , whereas wild type SHPS-1 did not . Positive_regulation AKT3 IL1B 12516562 1027883 *induced* phosphorylation of [PKB/Akt] depends on the presence of IRAK-1 . Positive_regulation AKT3 IL1B 12874320 1115031 A dominant negative mutant ( Mal-P/H ) of MyD88 adapter-like protein (Mal) , a protein with homology to MyD88 , failed to inhibit LPS- or *induced* [Akt] activity . Positive_regulation AKT3 IL1B 14612947 1163430 The PLC-PKC cascade is required for *dependent* Erk and [Akt] activation : their role in proliferation . Positive_regulation AKT3 IL1B 14612947 1163435 Pharmacological inhibition of the PLC-PKC cascade by using specific inhibitor for PLC-gamma ( U73122 ) and PKC ( GFX ) strongly inhibited *induced* Erk and [Akt] activation . Positive_regulation AKT3 IL1B 14612947 1163448 Taken together , our results suggest that a SHPS-1-PLC-gamma complex activate the PLC-PKC cascade , which is required for the activation of *dependent* Erk and [Akt] signalings and cell proliferation . Positive_regulation AKT3 IL1B 14764725 1207383 Antioxidant treatment of LPS stimulated neutrophils also inhibited the production of proinflammatory cytokines ( TNF-alpha , macrophage inflammatory protein-2 , and ) , as well as *activation* of the kinases IkappaB kinase alpha , IkappaB kinase beta , p38 , [Akt] , and extracellular receptor activated kinases 1 and 2 . Positive_regulation AKT3 IL1B 17291458 1710972 Curcumin inhibited the *induced* stimulation of up-stream protein kinase B [Akt] . Positive_regulation AKT3 IL1B 17299794 1718841 Src , PDGFR , and [PI3K/Akt] *mediated* the effects of because pretreatment with PP1 , AG1296 , and wortmannin also abrogated IL-1beta stimulated Src , PDGFR , and Akt phosphorylation , respectively . Positive_regulation AKT3 IL1B 17645739 1793265 Interestingly , Dex attenuated *mediated* activation of p38 MAPK and JNK , but not of [AKT] . Positive_regulation AKT3 IL1B 17920534 1804185 SA981 at a concentration of 100 microM partially inhibited *induced* phosphorylation of p38MAPK and [Akt] ( 12.0 % and 36.1 % inhibition of each total amount of phosphoprotein under IL-1beta coexistence condition , respectively ) . Positive_regulation AKT3 IL1B 20067833 2212261 These results indicated that glucose induced endogenous expression *increased* betaTC-6 cells apoptosis by inhibiting , at least in part , [IRS-2/Akt] mediated signalling through SOCS-1 upregulation . Positive_regulation AKT3 INPP4B 24288008 2926681 We further demonstrate that *regulates* [PI3K/Akt] signaling and exerts a tumor suppressor effect , impacting the proliferative , invasive , and tumorigenic capacity of melanoma cells . Positive_regulation AKT3 IRS4 10594015 654762 also *promoted* the activation of [PKB/Akt] and BAD phosphorylation during insulin stimulation ; Positive_regulation AKT3 IRS4 19029952 2029402 Once expressed , as well as binding to E1A and the insulin receptor , remains tyrosine phosphorylated and constitutively associates with the regulatory p85 subunit of phosphoinositide 3 kinase , *resulting* in the phosphorylation of [Akt] ( causing activation ) and GSK-3beta ( causing inhibition ) . Positive_regulation AKT3 ITGAL 18209096 1857849 CD28 ( - ) T cells , which are overrepresented in RA patients , have high cell surface expression and *induce* [Akt] phosphorylation in FLS more potently than their CD28 ( + ) counterparts . Positive_regulation AKT3 ITGB2 14960575 1227753 We have identified Vav , a guanine nucleotide exchange factor for Rac-1 , and PI3K/Akt , as regulators of the activation and inactivation phases of the activity of Rac-1 , respectively , in the context of LFA-1 signaling based on the following experimental evidence : ( i ) *induced* activation of Vav and [PI3K/Akt] with kinetics consistent with a regulatory role for these molecules on Rac-1 , ( ii ) overexpression of a constitutively active Vav mutant induces activation of Rac independently of LFA-1 stimulation whereas overexpression of a dominant negative Vav mutant blocks LFA-1 mediated Rac activation , ( iii ) pharmacological inhibition of PI3K/Akt prevented the fall in the activity of Rac-1 after its initial activation but had no effect on Vav activity , and ( iv ) overexpression of a dominant negative or a constitutively active Akt-1 induced or inhibited , respectively , Rac-1 activity . Positive_regulation AKT3 ITGB2 19630789 2112992 In microglia , fibrinogen mediates *activation* of [Akt] and Rho via the integrin receptor , while in neurons fibrinogen induces phosphorylation of epidermal growth factor (EGF) receptor via the alphavbeta3 integrin . Positive_regulation AKT3 LAMB3 22673183 2669806 Laminin-332 upregulation was also observed in CAFs and NBFs , but at a lower level than in InFs . *induced* [Akt] ( Ser473 ) phosphorylation by binding to integrin a3ß1 . Positive_regulation AKT3 MAOA 24865426 2945520 dependent activation of neuropilin-1 *promoted* [AKT/FOXO1/TWIST1] signaling , allowing FOXO1 binding at the TWIST1 promoter . Positive_regulation AKT3 MAP2K6 10331501 614648 However , neither two PI-3 kinase inhibitors , wortmannin and LY294002 , nor inhibitor PD98059 inhibited GM-CSF induced survival of eosinophils , although wortmannin and PD98059 *inhibited* GM-CSF induced [Akt] phosphorylation and MAP kinase activation in eosinophils , respectively . Positive_regulation AKT3 MAP2K6 10872812 707117 While the IGF-I induced activation of [PKB/Akt] was *inhibited* by PI3-K inhibitor LY294002 but not by inhibitor PD98059 , the activation of both MEK and ERK by IGF-I was inhibited by both . Positive_regulation AKT3 MAP2K6 10945642 721608 Phosphorylation of the cell survival promoting kinase Akt ( protein kinase B ) resulted from SF/HGF treatment of U373 cells , and both [Akt] phosphorylation and cell survival induced by SF/HGF were *inhibited* by phosphatidylinositol 3-kinase inhibitors but not by inhibitors of or protein kinase C. Cytoprotection by SF/HGF in vitro was also inhibited by transient expression of dominant negative Akt . Positive_regulation AKT3 MAP2K6 11454948 837898 Therefore , it is not clear whether inhibition of activation of [Akt] *resulted* from selective inhibition of or from additional actions on other unidentified common pathways . Positive_regulation AKT3 MAP2K6 11479233 842235 Inhibitors of ( U0126 ) and PI3K ( LY294002 ) *blocked* p42/p44 ( erk ) and [Akt] , respectively , and partially blocked HGF induced production of IL-8 and VEGF , whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A . Positive_regulation AKT3 MAP2K6 12114408 964055 Our results suggest the combination of paclitaxel and inhibitor *leads* to down-regulation of the [PI3K-Akt] signaling in addition to the proapoptotic effects of paclitaxel and MEK inhibitor alone . Positive_regulation AKT3 MAP2K6 12181443 977651 [Akt] activation induced by lysophosphatidic acid and sphingosine-1-phosphate *requires* both and p38 mitogen activated protein kinase and is cell-line specific . Positive_regulation AKT3 MAP2K6 12181443 977770 However , epidermal growth factor , thrombin , and endothelin-1 stimulated [Akt] S473 phosphorylation *require* p38 but not . Positive_regulation AKT3 MAP2K6 14719071 1197715 In cisplatin-resistant UM-SCC-23 in culture , which we have established , the protein levels of Ras , Raf-1 and were drastically elevated compared to parent UM-SCC-23 , and ERK and [Akt] signals were constitutively *activated* . Positive_regulation AKT3 MAP2K6 14993781 1216078 Furthermore , using Ad MEK DN , a dominant negative form of MEK , it was found that negatively *regulates* [Akt] phosphorylation upon IGF-1 stimulation . Positive_regulation AKT3 MAP2K6 15607817 1357054 Furthermore , U0126 and LY294002 , which respectively inhibit *induced* ERK phosphorylation and PI3 kinase mediated [Akt] phosphorylation had distinct effects on C3a induced responses . Positive_regulation AKT3 MAP2K6 15618457 1387753 The PI3K inhibitors wortmannin and LY-294002 and an [Akt] *inhibitor* , 1-L-6-hydroxymethyl-chiro-inositol 2- ( R ) -2-O-methyl-3-O-octadecylcarbonate , but not a inhibitor PD-98059 , blocked isoproterenol mediated eosinophil survival . Positive_regulation AKT3 MAP2K6 15767555 1384181 These events were associated with marked down-regulation of Raf-1 , , and ERK phosphorylation , diminished [Akt] *activation* , and enhanced phosphorylation of c-Jun NH2-terminal kinase (JNK) . Positive_regulation AKT3 MAP2K6 15801908 1432365 The ( MAPK/ERK kinase ) inhibitors PD98059 and U0126 blocked IGF-I stimulated ERK phosphorylation but did not *block* the phosphorylation of [Akt] and did not decrease proteoglycan synthesis . Positive_regulation AKT3 MAP2K6 16176063 1457737 The LPA induced phosphorylation of ERK 1/2 and CREB was blocked by inhibition of PI3K , PKC and , but that of [Akt] was only *inhibited* by wortmannin , the PI3K inhibitor . Positive_regulation AKT3 MAP2K6 16181409 1461925 The importance of these pathways was further confirmed by the activation of both ERK , in a *dependent* manner , and [Akt] , via PI3K . Positive_regulation AKT3 MAP2K6 16877565 1638828 However , inhibitors of Raf-1 and or a dominant negative ERK mutant *blocked* FKN induced ERK , but not [Akt] and eNOS , phosphorylation . Positive_regulation AKT3 MAP2K6 18586026 1953402 These data show that TGF-beta induced NFkappaB activation is through mediated [AKT] *activation* , which is essential for TGF-beta to support of osteoclast survival . Positive_regulation AKT3 MAP2K6 18656513 1972876 was *required* for phosphorylation of ERK and CREB , but not [Akt] , whereas G ( 0 ) /G ( i ) -proteins were necessary for phosphorylation of Akt and CREB , and cGMP was necessary for Akt phosphorylation . Positive_regulation AKT3 MAP2K6 20542106 2301984 Activation of these pathways by ATP seemed to be independent , since LY294002 and U0126 , inhibitors of PI3K and , did not *block* the activation of ERK and [AKT] , respectively , although each compound blocked its respective target . Positive_regulation AKT3 MAP2K6 20668435 2317132 In addition , DHA caused [AKT] and ERK activation in a time dependent manner , and the DHA induced HO-1 upregulation could be *attenuated* by PI-3 kinase/AKT and inhibitors . Positive_regulation AKT3 MAP2K6 21557297 2464100 Pharmacologic inhibition of EGFR , , and PI3K kinase activity in SCC10A *reduced* phosphorylated levels of ERK-1/2 and [AKT] , production of MMP-9 and sE-cad , cell migration and invasion , and expressional changes of EMT markers ( E-cadherin and N-cadherin ) induced by EGF , indicating that EGFR activation promotes cell migration and invasion via ERK-1/2 and PI3K regulated MMP-9/E-cadherin signaling pathways . Positive_regulation AKT3 MAP2K6 22674052 2719230 Besides , expression of [phosphorylated-AKT] and phosphorylated-ERK1/2 in fluoxetine treated NSCs was effectively *blocked* ( P < 0.05 ) by both PI3-K inhibitor ( LY294002 ) and inhibitor ( PD98059 ) . Positive_regulation AKT3 MAP2K6 22964641 2827269 In defining each pathway 's contributions , we found that [AKT] inhibition alone maximally *induced* GAPDH nuclear accumulation , whereas inhibition alone had no effect on GAPDH localization . Positive_regulation AKT3 MAP2K6 23199222 2730632 Furthermore , specific PI3K inhibitors abrogated the phosphorylation of Erk1/2 , while inhibition of did not *prevent* the phosphorylation of [Akt] . Positive_regulation AKT3 MAP2K6 23817184 2815731 [Akt] was also activated under the basal conditions , and the activation was *suppressed* by a inhibitor and an ERK1/2 inhibitor . Positive_regulation AKT3 MAP2K6 24530412 2924311 It is noteworthy that a tyrosine kinase receptor inhibitor , K252a , an inhibitor ( U0126 ) , and a PI3Kinase-Akt inhibitor ( LY294002 ) remarkably *attenuated* TrkB , ERK , and [Akt] phosphorylation as well as increase of OPN mRNA expression in the HCEM cells , respectively . Positive_regulation AKT3 MAP2K6 24652289 2934708 Nearly all IRS1 Ser(P)/Thr ( P ) residues were stimulated by insulin and significantly suppressed by PI3K inhibition ; fewer were suppressed by [Akt] or mTOR inhibition , and none were *suppressed* by inhibition . Positive_regulation AKT3 MIP 24449419 2923104 Cadmium selectively *induces* and COX-2 through PTEN mediated [Akt] activation in RAW264.7 cells . Positive_regulation AKT3 NGFR 22880054 2641721 Whereas Src kinases are often required for Syk activation , we show here that [PI3K/Akt] *activation* and autocrine IL-10 production by involves the Src family kinase Fyn . Positive_regulation AKT3 PECAM1 15632208 1387985 Sphingosine kinase-1 enhances endothelial cell survival through a *dependent* activation of [PI-3K/Akt] and regulation of Bcl-2 family members . Positive_regulation AKT3 PECAM1 16118242 1454346 *Role* of in the shear-stress induced activation of [Akt] and the endothelial nitric oxide synthase (eNOS) in endothelial cells . Positive_regulation AKT3 PECAM1 16118242 1454357 Down-regulation of using a siRNA approach *attenuated* the shear-stress induced phosphorylation of [Akt] and eNOS , as well as the shear-stress induced accumulation of cyclic GMP levels while the shear-stress induced phosphorylation of AMPK remained intact . Positive_regulation AKT3 PECAM1 19390054 2094937 Inward remodeling was associated with *dependent* NFkappaB activation , surface adhesion molecule expression , and leukocyte infiltration as well as [Akt] activation and vascular cell proliferation . Positive_regulation AKT3 PECAM1 23292117 2742036 EGCG inhibited HPV-16 oncoprotein induced angiogenesis conferred by NSCLC through the inhibition of HIF-1a protein expression and HIF-1a dependent expression of VEGF , IL-8 , and as well as *activation* of [Akt] , suggesting that HIF-1a may be a potential target of EGCG against HPV related NSCLC angiogenesis . Positive_regulation AKT3 PLAT 17498240 1739845 Consistent with neurotrophic effects , *activated* Raf-K/ERK , PKC and [PI3-K/Akt] , 5-60 min after treatment . Positive_regulation AKT3 PLAT 22162045 2549122 We found that *induces* a catalytic independent rapid and sustained activation of extracellular signal regulated kinase ( ERK ) 1/2 , Jun N-terminal kinase (JNK) , [Akt] , and p38 signaling pathways . Positive_regulation AKT3 PLAT 23280993 2758109 Furthermore , rADAMTS13 downregulated *induced* phosphorylation of [Akt] and activation of RhoA . Positive_regulation AKT3 PLAT 23562854 2778001 Glucose deprivation induced activation of [PI3K-Akt-GSK3ß] , p38 and AMPK , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation AKT3 PLAU 12545160 1051059 Downregulation of *inhibits* migration and [PI3k/Akt] signaling in glioblastoma cells . Positive_regulation AKT3 PLAU 15874933 1405690 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , [Akt] , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Positive_regulation AKT3 PRODH 22796327 2660078 The results provide evidence that is essential in proline protection against hydrogen peroxide mediated cell death and that proline/PRODH helps *activate* [Akt] in cancer cells . Positive_regulation AKT3 S1PR3 12385647 1034872 We previously demonstrated that sphingosine 1-phosphate (S1P) induced PLD activation via the G-protein coupled receptor endothelial differentiation gene (EDG) <3/S1P(3)> was *involved* in S1P induced stimulation of PI 3-kinase and [Akt] . Positive_regulation AKT3 S1PR3 14657000 1202006 mediated [Akt] *activation* and cross-talk with platelet derived growth factor receptor ( PDGFR ) . Positive_regulation AKT3 S1PR3 14657000 1202009 Using mouse embryonic fibroblasts ( MEFs ) from S1P receptor knockout mice , we show here that was *required* for S473 phosphorylation of [Akt] by S1P . Positive_regulation AKT3 S1PR3 15334188 1291020 Finally , S1P also protects endothelial cells from apoptosis through *activation* of phosphatidylinositol [3-kinase/Akt/eNOS] via S1P(1) and receptors . Positive_regulation AKT3 SCGB3A1 16266985 1478900 , an inhibitor of cell growth , invasion , and [AKT] *activation* . Positive_regulation AKT3 SLC38A3 11208554 787169 *induction* of [Akt] phosphorylation was inhibited by the phosphoinositide 3-kinase ( PI 3-kinase ) inhibitors LY-294002 ( 10 microM ) and wortmannin ( 200 nM ) but not by the mitogen activated protein kinase kinase 1 inhibitor PD-98059 ( 50 microM ) . Positive_regulation AKT3 SLC38A3 11208554 787174 The p38 kinase inhibitor SB-203580 inhibited *induction* of [Akt] phosphorylation and activation at a concentration ( 10 microM ) 10-fold higher than necessary to block p38 kinase ( 1 microM ) , suggesting the possible involvement of kinase activities other than p38 kinase . Positive_regulation AKT3 SLC38A3 15331357 1287938 *induction* of [Akt] activation was reduced by > 60 % by both dominant negative Ras and Rho and by 30 % by dominant negative Cdc42 . Positive_regulation AKT3 SLC38A3 15351698 1292592 D2 , a CCKB receptor antagonist , inhibited *induction* of [Akt] phosphorylation , measured by Western blots with anti-phospho-Akt antibodies . Positive_regulation AKT3 SLC38A3 15351698 1292595 The intracellular calcium chelator BAPTA-AM , but not the PKC inhibitor GF109203X , blocked *induction* of [Akt] . Positive_regulation AKT3 SLC38A3 15351698 1292599 In conclusion , *induces* [Akt] through activation of CCKB receptors and of intracellular calcium dependent , PKC independent , pathways . Positive_regulation AKT3 SLC38A3 23376640 2747987 In addition , knockdown of STAT3 expression significantly attenuated *induced* [PI3K/Akt] activation , COX-2 expression , and cell proliferation . Positive_regulation AKT3 SPHK1 14742298 1242760 S1P activated [Akt] and ERK within minutes , and inhibition of *blocked* RSV induced ERK and Akt activation , leading to accelerated cell death after viral infection . Positive_regulation AKT3 SPHK1 15210766 1262035 Blocking acid ceramidase but not activity in alveolar macrophages *led* to decreased ERK and [Akt] activity and induction of cell death . Positive_regulation AKT3 SPHK1 16164409 1456259 Notably , activation of the PI3K downstream mediator [PKB/Akt] by GPCR ligands *involves* the activity of and is independent of EGFR signal transactivation . Positive_regulation AKT3 SPHK1 17114809 1677158 Tumor necrosis factor-alpha stimulated cell proliferation is mediated through *dependent* [Akt] activation and cyclin D expression . Positive_regulation AKT3 SPHK1 17114809 1677182 In contrast , TNF-alpha stimulated [Akt] phosphorylation , which was also required for DNA synthesis , was *attenuated* by inhibition or SphK1 knockdown by small interfering RNA . Positive_regulation AKT3 SPHK1 17114809 1677200 We conclude that dependent [Akt] *activation* plays a significant role in TNF-alpha induced cyclin D expression and cell proliferation . Positive_regulation AKT3 SPHK1 21163859 2407760 Loss of *diminished* ASM mediated [AKT] phosphorylation , but exogenous S1P induced AKT activation in hepatocytes . Positive_regulation AKT3 SPHK1 21848514 2510102 However , inhibition did *diminish* EGF ( epidermal growth factor ) -driven increases in S1P levels and [Akt] ( also known as protein kinase B ) /ERK ( extracellular-signal regulated kinase ) phosphorylation . Positive_regulation AKT3 SPHK1 24572701 2919813 In vitro , the inhibition of induced cell death in colon cancer cell lines and *attenuated* the serum dependent [PI3K/Akt] signaling . Positive_regulation AKT3 TGM2 18381937 1892946 *regulates* focal adhesion [kinase/AKT] activation by modulating PTEN expression in pancreatic cancer cells . Positive_regulation AKT3 TLR7 23979601 2850595 Both phosphatidylinositol 3-kinase [(PI3K)-Akt] and p38 mitogen activated protein kinase (MAPK) signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Positive_regulation AKT3 TLR7 23979601 2850956 These data describe a novel role for p38a-MK2/3 in regulating induced [Akt] *activation* in macrophages . Positive_regulation AKT3 TNF 10485710 644495 *activates* phosphatidylinositol-3-OH kinase ( PI(3)K ) and its downstream target [Akt] ( protein kinase B ) . Positive_regulation AKT3 TNF 10748004 690717 Here we report that both and IL-1 *activate* the anti-apoptotic protein kinase [Akt] in growth factor and serum deprived EC , assessed by Western blotting for phospho-Akt . Positive_regulation AKT3 TNF 11067939 747580 CPPD crystals were observed to *induce* a robust and transient activation of ERK1 , ERK2 , and [Akt] , whereas produced only a modest and delayed activation of Akt . Positive_regulation AKT3 TNF 11067939 747594 In the *presence* of , [Akt] activity was enhanced , and CPPD crystal induced activation of ERK1 and ERK2 was more sustained than with CPPD crystals alone , but TNF-alpha itself reduced the basal phosphotransferase activities of these MAP kinases . Positive_regulation AKT3 TNF 11247802 793340 The *activation* of phosphatidylinositol (PI) 3-kinase and [Akt/protein] kinase B (PKB) by and their roles on stimulation of protein synthesis were investigated in cultured neonatal rat cardiac myocytes . Positive_regulation AKT3 TNF 11247802 793349 *induced* marked activation of PI3-kinase and [Akt/PKB] , and the activation of PI3-kinase and Akt/PKB was rapid ( maximal at 10 and 15 min , respectively ) and concentration dependent . Positive_regulation AKT3 TNF 11247802 793357 Akt/PKB activation by TNF-alpha was inhibited by a PI3-kinase-specific inhibitor LY-294002 and adenovirus mediated expression of a dominant negative mutant of PI3-kinase , indicating that *activates* [Akt/PKB] through PI3-kinase activation . Positive_regulation AKT3 TNF 11356844 834414 *Activation* of phosphatidylinositol (PI) [3-kinase/Akt] signaling by activates IKK and NF-kappaB . Positive_regulation AKT3 TNF 11356844 834464 *activated* [Akt] in PC-3 cells , but not in DU145 cells , and the ability of TNF to activate NF-kappaB was blocked by pharmacological inhibition of PI 3-kinase activity in PC-3 cells , but not in DU145 cells . Positive_regulation AKT3 TNF 11418646 830255 *induced* activations of PI3K and [Akt] were inhibited by DMS . Positive_regulation AKT3 TNF 11423913 831043 These results suggest that *induced* MAP kinase and [PI3-kinase/Akt] signaling play important roles in protecting BAE cells from TNF cytotoxicity . Positive_regulation AKT3 TNF 11465707 839732 The levels of phosphorylated [Akt] and Akt kinase activity were increased by *stimulation* of primary RASF with ( 10 ng/ml ) . Positive_regulation AKT3 TNF 12034358 948249 In SAS cells , *induced* the phosphorylation of [Akt] at both Ser473 and Thr308 , causing the activation of Akt , and also induced the phosphorylation and degradation of IkappaB ( inhibitor of NFkappaB ) . Positive_regulation AKT3 TNF 12052823 968764 Treatment with two pharmacological inhibitors of NF-kappa B , SN50 and N-tosyl-l-phenylalanine chloromethyl ketone ( TPCK ) , blocks *induced* [Akt] activation . Positive_regulation AKT3 TNF 12052823 968773 These results suggest that NF-kappa B is required for mediated [Akt] *activation* and that it lies upstream of the stimulation of Akt . Positive_regulation AKT3 TNF 12060576 952777 Strikingly , the *activation* of p42 ( mapk/erk2 ) and [Akt] by was also inhibited in the presence of NaCl . Positive_regulation AKT3 TNF 12086898 895223 PI3K inhibition significantly enhanced the antiproliferative and proapoptotic effects of TNF-alpha in both cell lines , Ly294002 also blocked *induced* [Akt] activation but failed to alter cytoplasmic IkappaBalpha degradation or subsequent NF-kappaB nuclear translocation . Positive_regulation AKT3 TNF 12483539 1024791 In addition , PP1 substantially inhibited the IL-2beta- and *dependent* activation of Erk 1/2 and [Akt] . Positive_regulation AKT3 TNF 12714600 1100552 Phosphorylation of [Akt] and the mammalian target of rapamycin ( but not extracellular regulated kinase or PKCzeta ) in *response* to was inhibited by aspirin treatment . Positive_regulation AKT3 TNF 12748063 1119606 Additionally , ethanol exposed cells display a blunting of *induced* [Akt] activation and Bcl-2 antagonist of cell death phosphorylation that may account , in part , for the increased sensitivity of the mitochondria to Bax mediated damage . Positive_regulation AKT3 TNF 14532277 1174874 Phosphorylation of VEGFR2 at Tyr-801 and Tyr-1175 , the critical sites for VEGF induced PI3K-Akt signaling , was not involved in mediated [Akt] *activation* . Positive_regulation AKT3 TNF 14532277 1174893 Furthermore , but not VEGF *induced* activation of VEGFR2 , [Akt] , and EC migration are blunted in EC genetically deficient with Etk . Positive_regulation AKT3 TNF 14532277 1174906 Taken together , our data demonstrated that induces transactivation between Etk and VEGFR2 , and Etk directly *activates* [PI3K-Akt] angiogenic signaling independent of VEGF induced VEGFR2-PI3K-Akt signaling pathway . Positive_regulation AKT3 TNF 14623898 1200893 Down-regulation of PTEN by NIK/NF-kappaB results in activation of the PI3K/Akt pathway and augmentation of *induced* [PI3K/Akt] stimulation . Positive_regulation AKT3 TNF 14630924 1201131 Furthermore , flavopiridol suppressed *induced* activation of [Akt] . Positive_regulation AKT3 TNF 14764725 1207382 Antioxidant treatment of LPS stimulated neutrophils also inhibited the production of proinflammatory cytokines ( , macrophage inflammatory protein-2 , and IL-1beta ) , as well as *activation* of the kinases IkappaB kinase alpha , IkappaB kinase beta , p38 , [Akt] , and extracellular receptor activated kinases 1 and 2 . Positive_regulation AKT3 TNF 15265936 1275720 Celecoxib also inhibited the *induced* interaction of [Akt] with I kappa B alpha kinase (IKK) . Positive_regulation AKT3 TNF 15358188 1293390 Western blot analyses revealed that [Akt] , which acts as a survival factor in cells , was activated in SMP30 , but not mock , transfectants either in the *presence* or absence of plus Act-D . Positive_regulation AKT3 TNF 15530848 1332710 In contrast , antioxidants did not prevent *induced* [Akt] and NF-kappaB activation . Positive_regulation AKT3 TNF 15646653 1349893 Stimulation of human neutrophils with granulocyte colony stimulating factor ( G-CSF ) , granulocyte-macrophage CSF (GM-CSF) , or *resulted* in phosphorylation of [Akt] , the potency being GM-CSF > G-CSF = TNF , which was inhibited by wortmannin . Positive_regulation AKT3 TNF 15710601 1395742 Evodiamine also inhibited *induced* [Akt] activation and its association with IKK . Positive_regulation AKT3 TNF 15746249 1403189 Collectively , our results suggest that *induces* the caspase dependent degradation of [Akt] via the cleavage and ubiquitination of Akt , which results in its degradation through the 26S proteasome . Positive_regulation AKT3 TNF 15792609 1386789 By stimulation of in AM-1 cells , the phosphorylation of [Akt] ( Ser473 ) and p44/42 mitogen activated protein kinase (MAPK) ( Thr202/Tyr204 ) was markedly *increased* in TNFalpha concentration and time dependent manner . Positive_regulation AKT3 TNF 15792609 1386818 Meanwhile , pretreatment with LY294002 , phosphatidylinositol-3-OH kinase (PI3K) inhibitor , could inhibit both *induced* phosphorylation of [Akt] ( Ser473 ) and p44/42 MAPK ( Thr202/Tyr204 ) . Positive_regulation AKT3 TNF 15793306 1387008 Methyl-beta-cyclodextrin did not alter total cell surface expression of TNFR1 or TNF induced degradation of IkappaBalpha , a measure of nuclear factor-kappaB activation , but it did inhibit *induced* phosphorylation of [Akt] , a measure of phosphatidylinositol-3 kinase activation . Positive_regulation AKT3 TNF 15808421 1391135 Similarly , DEM and CDNB inhibited *induced* [Akt] and eNOS phosphorylation , suggesting that thiol modification is involved in eNOS inductive pathways . Positive_regulation AKT3 TNF 15841081 1403987 However , gefitinib inhibited the *induced* activation of MAPKs and [Akt] . Positive_regulation AKT3 TNF 15953363 1421743 It inhibits *induced* PI3-kinase , [Akt] and NF-kappaB activation in these cells . Positive_regulation AKT3 TNF 16025396 1435606 *activated* the phosphorylation of p44/42 MAPK , p38 MAPK , SAPK/JNK and [Akt] in mesangial cells . Positive_regulation AKT3 TNF 16025396 1435622 PGE1 inhibited the *induced* phosphorylation of SAPK/JNK and [Akt] , but not p44/42 MAPK and p38 MAPK . Positive_regulation AKT3 TNF 16051251 1525212 Statin treatment of cells abrogated *induced* [Akt] phosphorylation and p65 nuclear translocation . Positive_regulation AKT3 TNF 16140562 1499248 These results suggested that TNFalpha induced both cell survival and apoptosis pathways in ameloblastoma and potential of TNFalpha in inducing apoptosis can be improved by inhibiting *induced* [Akt] and p44/42 mitogen activated protein kinase (MAPK) cell survival pathways . Positive_regulation AKT3 TNF 16230421 1470275 4-HPR also inhibited *induced* [Akt] activation linked with IKK activation . Positive_regulation AKT3 TNF 16269668 1502347 In human endothelial cells , we found that eNOS activation by is time dependent and *requires* activation of [Akt] , a known eNOS activator . Positive_regulation AKT3 TNF 16291729 1526065 *Activation* of MAPK and [Akt] by anti-HER2/neu inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation AKT3 TNF 16354764 1519360 Moreover , *induced* phosphorylation of [Akt] and extracellular signal regulated kinase ( ERK ) was blocked by glabridin treatment in HUVECs . Positive_regulation AKT3 TNF 16361577 1493168 However , *induced* [Akt] phosphorylation and IkappaB degradation were observed much less often in PC-9/ZD2001 cells than in PC-9 cells or PC-9/ZD2001R cells . Positive_regulation AKT3 TNF 16448212 1521717 PJ also abolished *induced* [AKT] activation , needed for NFkappaB activity . Positive_regulation AKT3 TNF 16794257 1631645 Quercetin also inhibited *induced* PI 3-kinase activity , [Akt] phosphorylation , intracellular H ( 2 ) O ( 2 ) production , NF-kappaB transactivation , IL-8 promoter activity , and steady-state mRNA levels , consistent with the notion that quercetin inhibits chemokine expression by attenuating NF-kappaB transactivation via a PI 3-kinase/Akt dependent pathway . Positive_regulation AKT3 TNF 16798728 1638520 Inhibition of Rac1 does not modulate *induced* ERK1/2 and [Akt] activation . Positive_regulation AKT3 TNF 16924232 1692173 Genetic deletion of PKR abrogates *induced* activation of IkappaBalpha kinase , JNK , [Akt] and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation . Positive_regulation AKT3 TNF 16924232 1692180 induced [Akt] *activation* needed for IKK activation was also abolished by deletion of PKR . Positive_regulation AKT3 TNF 16981137 1617032 *induced* the phosphorylation of [Akt] depending upon time . Positive_regulation AKT3 TNF 16981137 1617039 The phosphorylation of [Akt] *induced* by was markedly attenuated by LY294002 and wortmannin , inhibitors of PI3-kinase . Positive_regulation AKT3 TNF 16981137 1617043 PD98059 , a specific inhibitor of MEK , had little effect on the *induced* phosphorylation of [Akt] . Positive_regulation AKT3 TNF 17114809 1677183 In contrast , *stimulated* [Akt] phosphorylation , which was also required for DNA synthesis , was attenuated by SphK inhibition or SphK1 knockdown by small interfering RNA . Positive_regulation AKT3 TNF 17158207 1694188 Western blot analysis of L6 cell lysates demonstrated impaired insulin stimulated phosphorylation of [Akt] , serine/arginine-rich protein 40 , and glycogen synthase kinase 3beta in *response* to and the short chain C6 ceramide analog . Positive_regulation AKT3 TNF 17158602 1701118 In human tracheal smooth muscle cells , *induced* MMP-9 expression and [Akt] phosphorylation in a time dependent manner , which was attenuated by the inhibitors of Src ( PP1 ) , epidermal growth factor receptor ( AG1478 ) , PDGFR ( AG1296 ) , and PI3K ( LY294002 ) , respectively , revealed by reporter gene assay , RT-PCR , zymographic , and Western blot analyses . Positive_regulation AKT3 TNF 17158602 1701146 Thus , our study provides a new insight into the molecular mechanisms that *stimulated* [Akt] phosphorylation mediated through transactivation of Src and growth factor receptors may stimulate the recruitment of p300 , assemble transcription factor (p65) , and then lead to MMP-9 expression . Positive_regulation AKT3 TNF 17369858 1777762 Distinctive role of integrin mediated adhesion in *induced* [PKB/Akt] and NF-kappaB activation and endothelial cell survival . Positive_regulation AKT3 TNF 17369858 1777766 Taken together , these observations reveal a novel permissive role for integrins in *induced* [PKB/Akt] activation and prevention of TNF induced death distinct of NF-kappaB , and implicate the actin cytoskeleton in PKB/Akt mediated cell survival . Positive_regulation AKT3 TNF 17640567 1771203 Similarly , suppression of *induced* [AKT] activation by curcumin was also abrogated by glutathione . Positive_regulation AKT3 TNF 17971516 1859769 *induced* phosphorylation of [Akt] , and ERK1/2 was inhibited by an antibody against TNF-alpha receptor 1 (TNF-R1) . Positive_regulation AKT3 TNF 17971516 1859775 LY-294002 completely abolished *induced* stimulation of PS as well as phosphorylation of [Akt] and its downstream targets GSK-3 , p70 ( S6K ) , and 4E-BP1 . Positive_regulation AKT3 TNF 17994109 1851155 triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 MAPK , ERK 1/2 , SAPK/JNK and [Akt] activation , while increasing proliferation and migration . Positive_regulation AKT3 TNF 18091748 1847362 *induced* phosphorylation of extracellular signal regulated kinase ( ERK ) and [Akt] , but not p38 mitogen activated protein kinase (MAPK) , was attenuated by nicardipine , cilnidipine , benidipine , efonidipine , and azelnidipine . Positive_regulation AKT3 TNF 18180317 1856490 GLP-1 treatment also inhibited mediated *induction* of [Akt] phosphorylation . Positive_regulation AKT3 TNF 18227124 1895560 Moreover , *induced* [Akt] and CaM kinase II phosphorylation via cascades through Src/EGFR/PI3K and PLC/calcium/CaM , respectively . Positive_regulation AKT3 TNF 18273051 1931843 Here , we show that in normal keratinocytes and the transformed keratinocyte cell lines , HaCaT and A431 , *stimulates* protein kinase [B/Akt] , which results in activation of the survival complex mTORC1 ( mammalian target of rapamycin complex 1 ) and inhibition of the proapoptotic proteins Bad and FoxO3a . Positive_regulation AKT3 TNF 18287248 1896519 Flavopiridol suppresses *induced* activation of activator protein-1 , c-Jun N-terminal kinase , p38 mitogen activated protein kinase (MAPK) , p44/p42 MAPK , and [Akt] , inhibits expression of antiapoptotic gene products , and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells . Positive_regulation AKT3 TNF 18287248 1896538 It is noteworthy that this flavone also suppressed *induced* activation of [Akt] , a cell survival kinase , and expression of various antiapoptotic proteins , such as IAP-1 , IAP-2 , XIAP , Bcl-2 , Bcl-xL , and TRAF-1 . Positive_regulation AKT3 TNF 18490760 1917061 , in most cells examined , *activates* [Akt] to use IKKalpha to control mTOR activation . Positive_regulation AKT3 TNF 18490760 1917064 In MCF7 cells , does not *activate* [Akt] and requires IKKbeta to activate mTOR . Positive_regulation AKT3 TNF 18557926 1984196 We have recently shown that *induced* [Akt] activation may promote the early stages of skin cancer . Positive_regulation AKT3 TNF 18557926 1984200 In this work , we demonstrate that in the premalignant keratinocyte cell line HaCaT , *activates* [Akt] , ERK1/2 and p38 . Positive_regulation AKT3 TNF 18557926 1984204 The *dependent* phosphorylation of [Akt-ERK1/2] was slightly decreased by NF kappaB inhibition and in the presence of p38 blockers . Positive_regulation AKT3 TNF 18632801 1972584 also *caused* [PI3-kinase/Akt] activation , which was further increased by PDTC and prevented by the PI3-kinase inhibitor , LY294002 . Positive_regulation AKT3 TNF 19234337 2079528 However , *induced* [Akt] phosphorylation was blocked , and inhibiting Akt dramatically decreased CCL2 production . Positive_regulation AKT3 TNF 19275968 2072839 *stimulated* the phosphorylation levels of p38 MAPK , JNK , ERK1/2 and [Akt] in vascular endothelial cells . Positive_regulation AKT3 TNF 19404960 2075181 Inhibition of Mcl-1 by EGCG triggered caspase 3 activity in RA synovial fibroblasts , which was mediated via down-regulation of the *induced* [Akt] and NF-kappaB pathways . Positive_regulation AKT3 TNF 19760502 2264286 Moreover , *promoted* ErbB-2/ErbB-3 heterocomplex formation , [Akt] activation and NF-kappaB transcriptional activation . Positive_regulation AKT3 TNF 19879324 2197036 Rapamycin enhanced the IL-6 synthesis and the phosphorylation of [Akt] *induced* by also in human osteoblasts . Positive_regulation AKT3 TNF 20082310 2212578 *increased* the FAK , PI3K , and [Akt] phosphorylation . Positive_regulation AKT3 TNF 20135642 2235887 also *increased* the [Akt] and mTOR phosphorylation . Positive_regulation AKT3 TNF 20237236 2259890 *caused* activation of NF-kappaB , MAP kinases , and [PI3K-Akt] in podocytes , whereas blockade of these molecules did not affect inhibition of RAR by TNF-alpha . Positive_regulation AKT3 TNF 20333651 2266139 On the other hand , *stimulated* the phosphorylation of c-Src , EGFR , [Akt] , JNK1/2 , and c-Jun , which were inhibited by pretreatment with Gö6983 . Positive_regulation AKT3 TNF 20333651 2266152 We also showed that *induced* Akt translocation and the formation of an [Akt/p65/p300] complex . Positive_regulation AKT3 TNF 20562516 2290158 NAC also inhibited *induced* phosphorylation of [Akt] and NF-kappaB . Positive_regulation AKT3 TNF 20562516 2290165 W-7 and KN93 inhibited *induced* phosphorylation of [Akt] but not NF-kappaB . Positive_regulation AKT3 TNF 20732383 2363475 Wnt3a failed to affect the *induced* phosphorylation of p44/p42 MAP kinase , [Akt] , I?B or NF?B . Positive_regulation AKT3 TNF 20836895 2325631 LY294002 blocked *induced* phosphorylation of [Akt] and reduced the phosphorylation of both I?B-a and NF-?B . Positive_regulation AKT3 TNF 20937376 2375764 Three compounds all dose-dependently increased not only PPAR-? expression in EA.hy926 cells but inhibited *induced* phosphorylation of [Akt] , extracellular-signal regulated kinase ( ERK ) and protein kinase C ( PKC ) with different specificity . Positive_regulation AKT3 TNF 21040686 2339113 *activated* the protein kinase [B/Akt] and regulation of its downstream targets , mTOR , Bad and FoxO3a . Positive_regulation AKT3 TNF 21285293 2425714 Inhibitors of NADPH oxidase and/or p47phox siRNA diminished ROS production and COX-2 expression as well as phosphorylation of p38 mitogen activated protein kinase ( p38MAPK ) and [Akt] *mediated* either by AS serum or by . Positive_regulation AKT3 TNF 21300786 2403645 In addition to this effect , SubAB depressed basal and *induced* phosphorylation of [Akt] via the UPR . Positive_regulation AKT3 TNF 21344491 2415383 Consistently , treatment of HeLa cells with the compound significantly suppressed induced *activation* of [Akt] and phosphorylation of Ser536 in RelA/p65 , which is required for transactivation activity . Positive_regulation AKT3 TNF 21427355 2412170 In contrast to S6K1 , depletion of S6K2 by siRNA decreased basal and *induced* [Akt] phosphorylation . Positive_regulation AKT3 TNF 21545687 2554375 significantly *induced* phosphorylation of p38 MAPK , ERK , [Akt] and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation AKT3 TNF 21704193 2494339 3,4,5-Tricaffeoylquinic acid , Bay 11-7085 , Akt inhibitor and N-acetylcysteine inhibited the *induced* activation of NF-?B , activation of [Akt] , and formation of reactive oxygen and nitrogen species . Positive_regulation AKT3 TNF 21705614 2465728 Furthermore , luteolin inhibited *induced* phosphorylation of mitogen activated protein kinase/extracellular signal regulated kinase ( ERK ) kinase 1/ERK/p90 ( RSK ) , mitogen activated protein kinase kinase 4/c-Jun N-terminal kinase/c-Jun , and [Akt/p70] ( S6K ) . Positive_regulation AKT3 TNF 21856755 2473279 In addition , *induced* phosphorylation of extracellular signal regulated kinase , nuclear factor kappa B ( NF-?B ) and [Akt] in a time dependent manner , and increased nuclear translocation and promoter activity of NF-?B . Positive_regulation AKT3 TNF 21860594 2469243 Genipin dose- and time-dependently increased PPAR-? expression and inhibited *induced* phosphorylation of [Akt] and PKC with different degrees . Positive_regulation AKT3 TNF 22026410 2513649 Moreover , 1 abolished *induced* [Akt] phosphorylation . Positive_regulation AKT3 TNF 22433439 2588331 The use of inhibitors that block individual PI3K isoforms , including the novel selective PI3Kd inhibitor INK007 , showed that PI3Kd is required for PDGF- and *induced* [Akt] activation . Positive_regulation AKT3 TNF 22556157 2675441 LY294002 and wortmannin inhibited induced [Akt] *activation* , whereas only LY294002 inhibited CD38 expression . Positive_regulation AKT3 TNF 22561121 2608682 Zaprinast was found to activate ERK1/2 , p38 MAPK , JNK , NF?B , and [PI3K/Akt] , and subsequently , *induce* the mRNA expressions of IL-1a , IL-1ß , , CCL2 , CCL4 , CXCL1 , CXCL2 , and CD14 . Positive_regulation AKT3 TNF 22683933 2626481 Moreover , PA inhibited the *induced* phosphorylation of [AKT] , but not c-Jun N-terminal kinase , indicating that inhibition of survival signaling pathways activated by TNF-a may explain the effects of PA on TNF-a induced cytotoxicity . Positive_regulation AKT3 TNF 23243069 2757878 The inhibition of iTreg differentiation by TNF-a is mediated through a signaling cascade involving the induction of expression and the *activation* of [Akt] . Positive_regulation AKT3 TNF 23243069 2757881 Interestingly , this regulatory pathway is iTreg cell specific as does not *activate* [Akt] in naturally occurring regulatory T cells , therefore conferring a selective effect of TNF-a and its antagonism on iTreg cells . Positive_regulation AKT3 TNF 23328930 2798708 Immunofluorescence staining showed that alone *increased* the production of [P-Akt] , whereas LY294002 and 50 µM resveratrol suppressed the TNF-a stimulated expression of P-Akt . Positive_regulation AKT3 TNF 23333920 2758379 Interestingly , IL-27 promoted the basal and enhanced *induced* phosphorylation of p38 MAPK and [Akt] , but not I?Ba . Positive_regulation AKT3 TNF 23353699 2754234 In addition , *stimulated* [Akt] phosphorylation was inhibited by PP1 , AG1478 , AG1296 , or LY294002 . Positive_regulation AKT3 TNF 23632129 2790731 LAR also enhanced *induced* phospho-p38 and [phospho-AKT] expression , but inhibited the expression of phospho-JNK and nuclear translocation of NF-?Bp65 in RA synovial fibroblasts . Positive_regulation AKT3 TNF 23699531 2792338 Recombinant PGRN or transfection of a cDNA encoding PGRN did not antagonize *dependent* NF?B , [Akt] , and Erk1/2 pathway activation ; Positive_regulation AKT3 TNF 23710745 2792802 also significantly *activated* the phosphorylation of PTEN , [AKT] and FOXO3a ( P < 0.05 ) . Positive_regulation AKT3 TNF 24151609 2859754 In our study , we found that a treatments *induce* MEK and [AKT] phosphorylation . Positive_regulation AKT3 TNF 24361597 2911239 *stimulated* [Akt] phosphorylation was inhibited by genistein , PP1 , AG1296 , LY294002 , or SH5 . Positive_regulation AKT3 TNF 24441870 2922927 We showed that markedly *stimulated* Jak2 , PDGFR , [Akt] , and p42/p44 MAPK phosphorylation , which were attenuated by their respective inhibitors . Positive_regulation AKT3 TNF 24441870 2922943 Moreover , *stimulated* [Akt] activation via a Jak2/PDGFR pathway in HPAEpiCs . Positive_regulation AKT3 TNF 24441870 2922982 On the other hand , could *induce* [Akt] and p42/p44 MAPK translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation AKT3 TNFSF10 11992615 938785 In addition , combined and wortmannin treatment *resulted* in cleavage of several proteins : PARP , [Akt] , p21/WAF1 , and MDM2 as well as dephosphorylation of Akt . Positive_regulation AKT3 TNFSF10 12668516 1085982 *activated* the protein kinase [Akt] in HUVECs , as assessed by Western blot for phospho-Akt . Positive_regulation AKT3 TNFSF10 12807432 1101894 rapidly ( from 20 min ) *induced* the phosphorylation of [Akt] and ERK , but not of c-Jun NH2-terminal kinase (JNK) . Positive_regulation AKT3 TNFSF10 15289937 1278543 Western blot analysis consistently showed that *induced* a significant activation of ERK1/2 , and a much weaker phosphorylation of [Akt] , while it did not affect the p38/MAPK pathway . Positive_regulation AKT3 TNFSF10 15711939 1373719 Conversely , *induced* caspase dependent cleavage of [Akt] neutralizing its anti-apoptotic effects . Positive_regulation AKT3 TNFSF10 17595512 1764779 *induced* the phosphorylation of ERK1/2 , but not of [Akt] . Positive_regulation AKT3 TNFSF10 19573813 2104768 Src *mediates* [AKT] regulation and cancer cell survival responses to CXCL12 and ( TRAIL ) , factors that are distinctively expressed in the bone metastasis microenvironment . Positive_regulation AKT3 TNFSF10 19861161 2184427 Data from gene knockdown experiments with an RNA interference ( RNAi ) technique show that c-Cbl is involved in the interaction between Src and PI3K p85 during TRAIL treatment , playing an important role in *induced* [Akt] phosphorylation . Positive_regulation AKT3 TNFSF10 20149311 2179053 Notably , CaMKII chemical inhibitor abrogated *induced* phosphorylation of [Akt] . Positive_regulation AKT3 TNFSF10 20400979 2273978 Ovarian cancer ascites protects from *induced* cell death through alphavbeta5 integrin mediated focal adhesion kinase and [Akt] activation . Positive_regulation AKT3 TNFSF10 21109947 2366262 Akt catalytic activation is known to increase during metabolic oxidative stress , but we show that also dramatically *induces* the catalytic activation of [Akt] in TRAIL-sensitive cells , but not in TRAIL-resistant cells . Positive_regulation AKT3 TNFSF10 21472268 2361573 Further investigation revealed that engagement *led* to the activation of [PI3K/Akt] as well as of NF-?B . Positive_regulation AKT3 TNFSF10 21472268 2361583 Our data demonstrated that the *activation* of [PI3K/Akt] and NF-?B by is responsible for resistance to TRAIL in human gastric cancer cells . Positive_regulation AKT3 TNFSF10 23408429 2759801 Mechanically , MTDH down-regulated caspase-8 , decreased caspase-8 recruitment into the TRAIL death inducing signaling complex , decreased caspase-3 and poly(ADP-ribose) polymerase-2 processing , increased Bcl-2 expression , and stimulated *induced* [Akt] phosphorylation , without altering death receptor status . Positive_regulation AKT3 TNFSF10 24308965 2904861 HSP27 phosphorylation modulates *induced* activation of [Src-Akt/ERK] signaling through interaction with ß-arrestin2 . Positive_regulation AKT3 TNFSF10 24308965 2904865 In addition , reduced HSP27 phosphorylation by KRIBB3 treatment or MK2 knockdown attenuated the induced *activation* of [Akt] and ERK survival signaling through suppressing the phosphorylation of Src . Positive_regulation ALAS1 FOXO1 22070747 2548059 These findings support the notion that the complex is *involved* in the control of [ALAS1] expression and suggest further that a vanadate based therapy could be beneficial for the treatment of acute porphyria attacks . Positive_regulation ALAS1 PGC 22070747 2548060 These findings support the notion that the complex is *involved* in the control of [ALAS1] expression and suggest further that a vanadate based therapy could be beneficial for the treatment of acute porphyria attacks . Positive_regulation ALB ANGPT1 19297368 2086865 decreased water permeability ( L ( P ) : hydraulic conductivity ) in continuous and fenestrated microvessels and *increased* the retention of [albumin] ( sigma : reflection coefficient ) in continuous microvessels . Positive_regulation ALB ARSG 22102653 2509446 In those treated with turpentine , Hp reached its maximum value at 2 wk with a 2.7-fold increase , whereas *increased* 1.75-fold and [albumin] decreased 0.87-fold 1 wk after the induction of inflammation . Positive_regulation ALB TF 3111930 76432 Mean values of hemoglobin , [serum albumin] , and serum *increased* significantly through the therapeutic period ; Positive_regulation ALB TF 6638272 32854 Arm-muscle circumference , [serum albumin] , and levels markedly *increased* and became close to the normal values . Positive_regulation ALB TNF 12733374 895605 The levels of plasma ET , LPS , , IL-6 , IL-8 and urine RBP , TFR , ALB *increased* significantly at multiple time points as compared with those in the non-OJ patients ( P < 0.05 ) , and the changes of plasma ET , LPS , TNF-alpha , IL-6 , IL-8 are the same as those of urine RBP , TFR , [ALB] . Positive_regulation ALB TNF 14991464 1215466 We show that chicken egg [albumin-AGEs] prepared with glucose and chicken egg albumin-AGEs prepared with methylglyoxal dose-dependently *induce* release . Positive_regulation ALB TNF 24447355 2884388 The survival rate of 42 liver failure patients was 64.29 % , and the total bilirubin ( TBil ) , NH3 , total bile acid ( TBA ) and were decreased and the [albumin (ALB)] was *increased* after PE and DPMAS . Positive_regulation ALB TNF 7718622 301352 The binding of short-term glycated [albumin] to MonoMac 6 cells *induced* the production of the cytokines IL-1 and . Positive_regulation ALB TNF 7762602 308191 *increased* the diffusional transit of [ 3H ] sorbitol , [ 3H ] inulin , and 125I labeled [albumin] across confluent bovine aortic EC monolayers . Positive_regulation ALB TNF 8389399 220343 The lower concentration of Zn partially and the higher concentration totally prevented the *induced* increase in [albumin] transfer . Positive_regulation ALB TNF 8995714 409634 Glycated [albumin] *induced* increased mRNA expression and synthesis of . Positive_regulation ALDH2 ADH1B 20958327 2365143 The DNA damage induced by ethanol could be attenuated by or acetaldehyde dehydrogenase 2 (ALDH2) inhibitor , and the mRNA expression levels of ADH1B and [ALDH2] were *increased* markedly by ethanol . Positive_regulation ALDH2 DDAH2 18289604 1878534 Exogenous ADMA significantly enhanced ROS production/MDA concentration and *inhibited* [ALDH-2] activity , and overexpression of could significantly suppress GTN induced oxidative stress and inhibition of ALDH-2 activity , which is also attenuated by L-arginine . Positive_regulation ALDH2 GYS1 22524197 2595808 In summary , our data revealed that [ALDH2] *acted* against diabetes induced cardiac contractile and intracellular Ca2+ dysregulation , possibly through regulation of apoptosis , kinase-3ß activation and mitochondrial function independent of the global metabolic profile . Positive_regulation ALDH2 GYS2 22524197 2595809 In summary , our data revealed that [ALDH2] *acted* against diabetes induced cardiac contractile and intracellular Ca2+ dysregulation , possibly through regulation of apoptosis , kinase-3ß activation and mitochondrial function independent of the global metabolic profile . Positive_regulation ALDH2 NOS3 22155639 2536595 Here we show that in human aortic endothelial cells ( HAECs ) , rapid activation of mitochondrial [aldehyde dehydrogenase 2 (ALDH2)] mediates ethanol *induced* activation by preventing reactive oxygen species ( ROS ) accumulation . Positive_regulation ALDH2 PPARA 12604186 1062568 Recently , we have shown that enrichment of a highly deviated rat hepatoma cell line , JM2 , with arachidonic acid , a natural ligand of peroxisome proliferator activated receptors ( PPARs ) , inhibits growth , partially restores [ALDH2] and ALDH3 to their normal levels and *induces* expression . Positive_regulation ALDH2 PRKAA1 21130747 2372846 Malondialdehyde inhibits an *mediated* nuclear translocation and repression activity of [ALDH2] in transcription . Positive_regulation ALDH2 PRKAA1 21130747 2372864 In this study , we have demonstrated that [ALDH2] acts as a transcriptional repressor in *response* to activation , and MDA modifies ALDH2 and inhibits repressive activity of ALDH2 in general transcription . Positive_regulation ALDH2 PRKAA2 21130747 2372847 Malondialdehyde inhibits an *mediated* nuclear translocation and repression activity of [ALDH2] in transcription . Positive_regulation ALDH2 PRKAA2 21130747 2372865 In this study , we have demonstrated that [ALDH2] acts as a transcriptional repressor in *response* to activation , and MDA modifies ALDH2 and inhibits repressive activity of ALDH2 in general transcription . Positive_regulation ALDH2 PRKAB1 21130747 2372848 Malondialdehyde inhibits an *mediated* nuclear translocation and repression activity of [ALDH2] in transcription . Positive_regulation ALDH2 PRKAB1 21130747 2372866 In this study , we have demonstrated that [ALDH2] acts as a transcriptional repressor in *response* to activation , and MDA modifies ALDH2 and inhibits repressive activity of ALDH2 in general transcription . Positive_regulation ALDH2 PRKAB2 21130747 2372849 Malondialdehyde inhibits an *mediated* nuclear translocation and repression activity of [ALDH2] in transcription . Positive_regulation ALDH2 PRKAB2 21130747 2372867 In this study , we have demonstrated that [ALDH2] acts as a transcriptional repressor in *response* to activation , and MDA modifies ALDH2 and inhibits repressive activity of ALDH2 in general transcription . Positive_regulation ALDH2 PRKAG1 21130747 2372850 Malondialdehyde inhibits an *mediated* nuclear translocation and repression activity of [ALDH2] in transcription . Positive_regulation ALDH2 PRKAG1 21130747 2372868 In this study , we have demonstrated that [ALDH2] acts as a transcriptional repressor in *response* to activation , and MDA modifies ALDH2 and inhibits repressive activity of ALDH2 in general transcription . Positive_regulation ALDH2 PRKAG2 21130747 2372851 Malondialdehyde inhibits an *mediated* nuclear translocation and repression activity of [ALDH2] in transcription . Positive_regulation ALDH2 PRKAG2 21130747 2372869 In this study , we have demonstrated that [ALDH2] acts as a transcriptional repressor in *response* to activation , and MDA modifies ALDH2 and inhibits repressive activity of ALDH2 in general transcription . Positive_regulation ALG1 IL1B 10471781 642045 We found that IL-1alpha , and IL-6 *increased* both [metallothionein-1 (MT-1)] and metallothionein-2 (MT-2) mRNA in HepG2 cells . Positive_regulation ALG1 TNF 8181907 256448 [MT-I] was also *induced* in lung and heart by , but little by IL-6 . Positive_regulation ALK EPHB2 21415216 2416596 *Role* of and STAT3-survivin signaling pathways in [ALK] inhibitor induced apoptosis in EML4-ALK positive lung cancer . Positive_regulation ALK EPHB2 21415216 2416615 Forced expression of [EML4-ALK] *induced* marked activation of extracellular signal regulated kinase ( ) and STAT3 , but not that of AKT . Positive_regulation ALOX5 ACP1 18218859 1884177 In addition , inhibition of phosphatidic ( PA-P ) by propranolol or bromoenol lactone *caused* suppression of [5-LO] product formation and of translocation , which could be reversed by addition of exogenous OAG . Positive_regulation ALOX5 ACP2 18218859 1884178 In addition , inhibition of phosphatidic ( PA-P ) by propranolol or bromoenol lactone *caused* suppression of [5-LO] product formation and of translocation , which could be reversed by addition of exogenous OAG . Positive_regulation ALOX5 ACP5 18218859 1884179 In addition , inhibition of phosphatidic ( PA-P ) by propranolol or bromoenol lactone *caused* suppression of [5-LO] product formation and of translocation , which could be reversed by addition of exogenous OAG . Positive_regulation ALOX5 ACP6 18218859 1884180 In addition , inhibition of phosphatidic ( PA-P ) by propranolol or bromoenol lactone *caused* suppression of [5-LO] product formation and of translocation , which could be reversed by addition of exogenous OAG . Positive_regulation ALOX5 AFF1 25402609 2960346 was able to *enhance* [ALOX5] promoter activity by 47-fold , which was further stimulated when either vitamin D receptor and retinoid X receptor or SMAD3/SMAD4 were co-transfected . Positive_regulation ALOX5 AFF1 25402609 2960351 Surprisingly , a constitutive *activation* of [ALOX5] by was inhibited by class I HDAC inhibitors , by relieving inhibitory functions deriving from MLL . Positive_regulation ALOX5 ALOX5AP 1469057 207086 To examine the *role* of in A23187 induced translocation of [5-LO] to a membrane fraction , we have studied the A23187 stimulated translocation of 5-LO in osteosarcoma cells expressing both 5-LO and FLAP , and in osteosarcoma cells expressing 5-LO only . Positive_regulation ALOX5 ALOX5AP 16033810 1459603 The inhibitor reduced leukotriene (LT)B ( 4 ) and cysteinyl LT levels and *down-regulated* [5-LO] and FLAP protein expression in the liver . Positive_regulation ALOX5 ALOX5AP 24905297 2952070 Only in cells expressing FLAP and 5-LO , the FLAP antagonist MK886 blocked *mediated* increase in [5-LO] product formation , and prevented 5-LO nuclear membrane translocation and co-localization with FLAP . Positive_regulation ALOX5 ALOX5AP 7938075 276220 Inhibitors of function prevent translocation of 5-lipoxygenase from cytosol to the membrane and *inhibit* [5-LO] activation . Positive_regulation ALOX5 ALOX5AP 8245774 236936 These results demonstrate that the nuclear envelope is the intracellular site at which 5-LO and act to metabolize arachidonic acid , and that ionophore activation of neutrophils and monocytes *results* in the translocation of [5-LO] from a nonsedimentable location to the nuclear envelope . Positive_regulation ALOX5 ALOX5AP 8344271 226442 To study the mechanism by which *activates* [5-LO] , we compared cellular 5-LO activity in Sf9 cells expressing this enzyme to that in Sf9 cells coexpressing FLAP and 5-LO . Positive_regulation ALOX5 ALOX5AP 8440384 213303 However , the mechanism by which *activates* [5-LO] has not been determined . Positive_regulation ALOX5 ALOX5AP 8440384 213304 These studies suggest that may *activate* [5-LO] by specifically binding arachidonic acid and transferring this substrate to the enzyme . Positive_regulation ALOX5 ALOX5AP 9113110 425992 LTC4-S inhibition by FLAP inhibitors is in agreement with the significant homology reported for expression cloned LTC4-S with FLAP , Furthermore , functional homology of the binding sites for inhibitors on LTC4-S and FLAP is suggested by the conservation of the relative potencies of MK-886 and BAY-X1005 vs *dependent* [5-lipoxygenase] activity and LTC4-S inhibition : MK-886 was 19.3-fold more potent than BAY-X1005 as FLAP inhibitor and 19.6-fold more potent than BAY-X1005 as LTC4-S inhibitor . Positive_regulation ALOX5 APOB 8002971 257862 Oxidized low density *increases* U937 cell [5-lipoxygenase] activity : induction of 5-lipoxygenase activating protein . Positive_regulation ALOX5 C5 2986155 47762 One provocative interpretation of our results is that the [5-lipoxygenase] is *activated* by and that concomitant modulation of 5-lipoxygenase activity provides a means whereby arachidonic acid metabolism is directed in these cells to either the cyclooxygenase or lipoxygenase pathway . Positive_regulation ALOX5 CA2 12127993 966235 Thus , in broken cell preparations of human polymorphonuclear leukocytes ( PMNL ) and rat basophilic leukemia (RBL)-1 cells , 5-LO converted AA ( > 20 microM ) in the absence of Ca2+ , whereas was absolutely *required* for [5-LO] activity in broken cell preparations of MM6 cells . Positive_regulation ALOX5 CA2 12525578 1048066 However , in HeLa cells expressing a 5-LO mutant lacking potential 5-LO phosphorylation sites , removal of *caused* a prominent loss of [5-LO] activity . Positive_regulation ALOX5 CA2 12525578 1048068 Instead , [5-LO] activation in MM6 cells *required* or alternative signaling pathways induced by hyperosmotic stress . Positive_regulation ALOX5 CA2 12670876 1080140 Collectively , our data suggest that compared with *mediated* [5-LO] product formation , enzyme activation involving 5-LO phosphorylation events specifically and strongly alters the susceptibility of 5-LO toward nonredox-type inhibitors in intact cells . Positive_regulation ALOX5 CA2 12893830 1150173 Recently , we reported that in crude enzyme preparations , a monocyte derived soluble protein (M-DSP) renders [5-lipoxygenase (5-LO)] activity *dependent* . Positive_regulation ALOX5 CA2 12893830 1150177 Apparently , in the *presence* of , a low lipid hydroperoxide level is sufficient for [5-LO] activation . Positive_regulation ALOX5 CA2 15923196 1433695 However , in the *presence* of , OAG caused no stimulation of [5-LO] . Positive_regulation ALOX5 CA2 16275640 1509375 Importantly , experiments with the 5-LO activating protein inhibitor MK-0591 and the intracellular Ca2+ chelator BAPTA-AM demonstrated that the AA-regulated [5-LO] translocation is FLAP- and *dependent* . Positive_regulation ALOX5 CA2 2824200 79963 In PMN homogenates Dnp-Cl and Diamide were without effect and even caused inhibition when [5-lipoxygenase] was *stimulated* by and ATP . Positive_regulation ALOX5 CA2 2845484 98643 This suggests that is *required* for [5-lipoxygenase] activity on arachidonate ions in solution but possibly not on protonated arachidonic acid or micelles . Positive_regulation ALOX5 CA2 3118366 80192 Maximal activity of human leukocyte [5-lipoxygenase] *requires* , ATP , a microsomal membrane preparation , and two cytosolic stimulatory factors . Positive_regulation ALOX5 CA2 3126256 90435 The data suggest that Ca2+ regulates macrophage 20 : 4 metabolism at two distinct steps : an increase in intracellular regulates the triggering signal and relatively higher Ca2+ concentrations are *required* for [5-lipoxygenase] activity . Positive_regulation ALOX5 CA2 3134355 94308 Furthermore , although the pellet associated enzyme recovered from ionophore treated leukocytes was inactive , an irreversible , *dependent* membrane association of active [5-lipoxygenase] could be demonstrated in cell-free systems . Positive_regulation ALOX5 CA2 3134355 94310 Together these results are consistent with the hypothesis that ionophore treatment results in a *dependent* translocation of [5-lipoxygenase] from the cytosol to a membrane bound site , that the membrane associated enzyme is preferentially utilized for LT synthesis , and that it is consequently inactivated . Positive_regulation ALOX5 CA2 3143404 100916 *induced* the membrane association of [5-lipoxygenase] when added into the incubation mixtures containing the membrane fraction with either the cytosolic fraction or the purified enzyme . Positive_regulation ALOX5 CA2 3382674 94797 Moreover , the [5-lipoxygenase] and leukotriene A4 synthase activities *require* significantly lower levels for maximal activation than has been reported previously . Positive_regulation ALOX5 CA2 7811715 285056 In the *presence* of ( 1 microM or less ) , PC liposomes distinctly stimulated the dual activities of [5-LO] for the production of 5-HPETE from arachidonate and for its subsequent conversion to LTA4 . Positive_regulation ALOX5 CALCA 24516701 2914485 We report that the gastroprotective effect of SK-MS10 in an ethanol induced gastric damage rat model is mediated by suppressing proinflammatory cytokines and downregulating cytosolic phospholipase A2 (cPLA2) , [5-lipoxygenase (5-LOX)] , and the *activation* of gene related peptide . Positive_regulation ALOX5 CALML3 19807693 2184059 In the present paper we report that also *stabilizes* [5-LO] and prevents non-turnover inactivation of the enzyme in vitro . Positive_regulation ALOX5 CALML3 25034252 2953255 Expression of *increased* MM6 cellular [5LO] activity for all stimuli tested . Positive_regulation ALOX5 CASP6 16135563 1454505 Caspase activation and [5-LO] degradation were blocked by the protein-synthesis inhibitor cycloheximide , and cell-permeable peptide inhibitors of and casp-8 *prevented* 5-LO cleavage . Positive_regulation ALOX5 CASP8 16135563 1454506 Caspase activation and [5-LO] degradation were blocked by the protein-synthesis inhibitor cycloheximide , and cell-permeable peptide inhibitors of casp-6 and *prevented* 5-LO cleavage . Positive_regulation ALOX5 CD3D 7737277 305433 Diacylglycerol lipase activation and [5-lipoxygenase] activation and translocation *following* triggering in T cells . Positive_regulation ALOX5 CD3E 7737277 305434 Diacylglycerol lipase activation and [5-lipoxygenase] activation and translocation *following* triggering in T cells . Positive_regulation ALOX5 CD3G 7737277 305435 Diacylglycerol lipase activation and [5-lipoxygenase] activation and translocation *following* triggering in T cells . Positive_regulation ALOX5 CD40 21200133 2391718 The association of CD40 with [5-LO] is *dependent* on ligation in Raji B cells , and co-immunoprecipitation experiments using epitope- tagged proteins transiently expressed in human embryonic kidney 293T cells revealed the role of the regulatory subunit of PI3K , p85 , in this association . Positive_regulation ALOX5 CDC73 1846895 153370 These results indicate that preincubation of peripheral blood neutrophils with GM-CSF enhances the ability of PAF to stimulate leukotriene synthesis by increasing both arachidonic acid availability and [5-lipoxygenase] activation in *response* to . Positive_regulation ALOX5 CDC73 8415804 234046 Although the early pulmonary vascular response ( < 10 min ) to PAF is dependent on cyclooxygenase products , the sustained response ( after 10 min ) can not be explained by either [5-lipoxygenase] or cyclooxygenase products but may be *mediated* directly by receptors . Positive_regulation ALOX5 CDC73 8666909 369186 Lipid body induction by *required* [5-lipoxygenase (LO)] activity and was inhibited by the 5-lipoxygenase activating protein antagonist MK 886 and the 5-LO inhibitor zileuton , but not by cyclooxygenase inhibitors . Positive_regulation ALOX5 CDC73 9516893 477386 These findings indicate that , in neutrophils from asthmatic patients , enhances LTB4 release and *increases* [5-lipoxygenase] activity and intracellular calcium to a greater extent than in neutrophils from non-asthmatic patients . Positive_regulation ALOX5 COA1 19754384 2140384 In addition , novel substances such as HDL related agents , cyclopentenone prostaglandins , lipoprotein associated phospholipase A(2) inhibitors , [5-lipoxygenase] pathway *inhibitors* , acyl : cholesterol acyltransferase inhibitors , analogues of probucol and lysophosphatidic acid antagonists have been developed for the treatment of atherosclerosis as a consequence of their actions on oxidative stress and inflammation . Positive_regulation ALOX5 COA3 19754384 2140386 In addition , novel substances such as HDL related agents , cyclopentenone prostaglandins , lipoprotein associated phospholipase A(2) inhibitors , [5-lipoxygenase] pathway *inhibitors* , acyl : cholesterol acyltransferase inhibitors , analogues of probucol and lysophosphatidic acid antagonists have been developed for the treatment of atherosclerosis as a consequence of their actions on oxidative stress and inflammation . Positive_regulation ALOX5 COA4 19754384 2140385 In addition , novel substances such as HDL related agents , cyclopentenone prostaglandins , lipoprotein associated phospholipase A(2) *inhibitors* , [5-lipoxygenase] pathway inhibitors , acyl : cholesterol acyltransferase inhibitors , analogues of probucol and lysophosphatidic acid antagonists have been developed for the treatment of atherosclerosis as a consequence of their actions on oxidative stress and inflammation . Positive_regulation ALOX5 COA5 19754384 2140387 In addition , novel substances such as HDL related agents , cyclopentenone prostaglandins , lipoprotein associated phospholipase A(2) *inhibitors* , [5-lipoxygenase] pathway inhibitors , acyl : cholesterol acyltransferase inhibitors , analogues of probucol and lysophosphatidic acid antagonists have been developed for the treatment of atherosclerosis as a consequence of their actions on oxidative stress and inflammation . Positive_regulation ALOX5 COA6 19754384 2140383 In addition , novel substances such as HDL related agents , cyclopentenone prostaglandins , lipoprotein associated phospholipase A(2) *inhibitors* , [5-lipoxygenase] pathway inhibitors , acyl : cholesterol acyltransferase inhibitors , analogues of probucol and lysophosphatidic acid antagonists have been developed for the treatment of atherosclerosis as a consequence of their actions on oxidative stress and inflammation . Positive_regulation ALOX5 CRK 19908283 2203547 The mitogen activated protein kinase inhibitor , but not MEK inhibitor , *reduced* the increase in [5-LO] in spinal microglia . Positive_regulation ALOX5 CSF2 11090070 754421 Granulocyte-macrophage ( GM-CSF ) plus tumor necrosis factor-alpha (TNF-alpha) promoted DC differentiation and *induced* a strong rise in [5-LO] and FLAP expression . Positive_regulation ALOX5 CSF2 1966811 149812 Similarly , alone did not directly *activate* the [5-lipoxygenase] as determined by the 5-lipoxygenase mediated transformation of exogenous 15-hydroperoxyeicosatetraenoic acid into 5,15-dihydroxyeicosatetraenoic acid ( 5,15-diHETE ) . Positive_regulation ALOX5 CSF2 7513312 253703 by itself *induced* an increase in [5-lipoxygenase-specific] mRNA expression within 5 min . Positive_regulation ALOX5 CSF2 7780156 309467 Granulocyte-macrophage *increases* [5-lipoxygenase] gene transcription and protein expression in human neutrophils . Positive_regulation ALOX5 CSF2 8283055 247439 Granulocyte-macrophage *enhances* [5-lipoxygenase] levels in human polymorphonuclear leukocytes . Positive_regulation ALOX5 CSF2 8283055 247441 *induced* a dose- and time dependent de novo synthesis of the [5-LO] in PMNL , as determined by immunoprecipitation of 35S-methionine labeled 5-LO . Positive_regulation ALOX5 CSF2 8358016 227535 We found that *increased* [5-LO] activation elicited by platelet activating factor (PAF) , N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) , C5a , LTB4 , IL-8 and calcium ionophore A23187 , as determined by using an exogenous substrate . Positive_regulation ALOX5 CTR9 1846895 153371 These results indicate that preincubation of peripheral blood neutrophils with GM-CSF enhances the ability of PAF to stimulate leukotriene synthesis by increasing both arachidonic acid availability and [5-lipoxygenase] activation in *response* to . Positive_regulation ALOX5 CTR9 8415804 234047 Although the early pulmonary vascular response ( < 10 min ) to PAF is dependent on cyclooxygenase products , the sustained response ( after 10 min ) can not be explained by either [5-lipoxygenase] or cyclooxygenase products but may be *mediated* directly by receptors . Positive_regulation ALOX5 CTR9 8666909 369187 Lipid body induction by *required* [5-lipoxygenase (LO)] activity and was inhibited by the 5-lipoxygenase activating protein antagonist MK 886 and the 5-LO inhibitor zileuton , but not by cyclooxygenase inhibitors . Positive_regulation ALOX5 CTR9 9516893 477387 These findings indicate that , in neutrophils from asthmatic patients , enhances LTB4 release and *increases* [5-lipoxygenase] activity and intracellular calcium to a greater extent than in neutrophils from non-asthmatic patients . Positive_regulation ALOX5 DCP2 23642263 2795754 Recently , we have demonstrated that [5-LO] mRNA expression is *regulated* by alternative splicing and nonsense mediated ( NMD ) . Positive_regulation ALOX5 EPHB2 20554538 2327593 HNE induced [5-LO] expression is *regulated* by and Sp1/p38 MAPK pathways via EGF receptor in murine macrophages . Positive_regulation ALOX5 EXOSC10 23642263 2795757 Recently , we have demonstrated that [5-LO] mRNA expression is *regulated* by alternative splicing and nonsense mediated ( NMD ) . Positive_regulation ALOX5 EXOSC2 23642263 2795750 Recently , we have demonstrated that [5-LO] mRNA expression is *regulated* by alternative splicing and nonsense mediated ( NMD ) . Positive_regulation ALOX5 EXOSC4 23642263 2795752 Recently , we have demonstrated that [5-LO] mRNA expression is *regulated* by alternative splicing and nonsense mediated ( NMD ) . Positive_regulation ALOX5 GPX1 10880344 762380 but not -4 is *involved* in the regulation of cellular [5-lipoxygenase] activity in monocytic cells . Positive_regulation ALOX5 GRAP2 10779545 691014 At least two *dependent* [5-LO] kinase activities were found . Positive_regulation ALOX5 GRAP2 19135147 2031996 Collectively , these data suggest that MAPK *mediated* activation of [5-LO] by HNE might enhance CD36 expression , consequently leading to the formation of macrophage foam cells . Positive_regulation ALOX5 HDAC1 21883892 2617019 Knockdown of HDAC 1 , 2 and 3 revealed that HDAC2 and HDAC3 but not is *involved* in the up-regulation of [5-LO] mRNA expression . Positive_regulation ALOX5 HDAC1 25402609 2960348 Surprisingly , a constitutive activation of [ALOX5] by MLL-AF4 was *inhibited* by class I inhibitors , by relieving inhibitory functions deriving from MLL . Positive_regulation ALOX5 HDAC2 21883892 2617020 Knockdown of HDAC 1 , 2 and 3 revealed that and HDAC3 but not HDAC1 is *involved* in the up-regulation of [5-LO] mRNA expression . Positive_regulation ALOX5 HDAC2 25402609 2960349 Surprisingly , a constitutive activation of [ALOX5] by MLL-AF4 was *inhibited* by class I inhibitors , by relieving inhibitory functions deriving from MLL . Positive_regulation ALOX5 HDAC3 21883892 2617021 Knockdown of HDAC 1 , 2 and 3 revealed that HDAC2 and but not HDAC1 is *involved* in the up-regulation of [5-LO] mRNA expression . Positive_regulation ALOX5 HMOX1 19744468 2183318 The combinations were also found to suppress iNOS , COX-2 , [5-lipoxygenase (5-LOX)] and cPLA(2) but *induce* . Positive_regulation ALOX5 IL13 12654629 1073063 To investigate the potential role of leukotrienes ( LT ) in mediating these effects , we studied the ability of to *induce* the expression of [5-lipoxygenase (5-LO)] , we compared the effects of IL-13 and of various leukotrienes on different biological parameters and the interference by the 5-LO inhibitor zileuton ( orally , 50 mg/kg , 3 times a day for 3 days ) , and by some antagonists . Positive_regulation ALOX5 IL13 16849505 1588487 Lastly , mechanistic insights are provided by demonstrating that *induced* [5-LO] activation is required for optimal stimulation and activation of TGF-beta(1) and the inhibition of matrix metalloproteinase-12 . Positive_regulation ALOX5 IL1B 10022882 590385 Reactive oxygen intermediate dependent NF-kappaB activation by *requires* [5-lipoxygenase] or NADPH oxidase activity . Positive_regulation ALOX5 IL5 10384149 624803 We hypothesized that *induces* the expression of [5-LO] and/or its activating protein FLAP in eosinophils , and that this might be modulated by anti-inflammatory corticosteroids . Positive_regulation ALOX5 IL5 10384149 624805 Neither IL-5 nor dexamethasone altered [5-LO] expression , but significantly *increased* 5-LO immunofluorescence localizing to eosinophil nuclei . Positive_regulation ALOX5 IL5 11200053 779745 These findings suggest that *activates* both cPLA2 and [5-LO] but PAF activates only 5-LO . Positive_regulation ALOX5 IL8 8245474 236912 It was also found that *activates* the neutrophil [5-lipoxygenase (5-LO)] , the other key enzyme in LT biosynthesis . Positive_regulation ALOX5 IL8 8245474 236913 *induced* [5-LO] activation in a time- and concentration dependent manner , with a threshold at 1 nM , and prior treatment of neutrophils with GM-CSF enhanced this effect of IL-8 over the 1 to 300 nM range . Positive_regulation ALOX5 KMT2A 25402609 2960345 was able to *enhance* [ALOX5] promoter activity by 47-fold , which was further stimulated when either vitamin D receptor and retinoid X receptor or SMAD3/SMAD4 were co-transfected . Positive_regulation ALOX5 KMT2A 25402609 2960350 Surprisingly , a constitutive *activation* of [ALOX5] by was inhibited by class I HDAC inhibitors , by relieving inhibitory functions deriving from MLL . Positive_regulation ALOX5 LEO1 1846895 153374 These results indicate that preincubation of peripheral blood neutrophils with GM-CSF enhances the ability of PAF to stimulate leukotriene synthesis by increasing both arachidonic acid availability and [5-lipoxygenase] activation in *response* to . Positive_regulation ALOX5 LEO1 8415804 234050 Although the early pulmonary vascular response ( < 10 min ) to PAF is dependent on cyclooxygenase products , the sustained response ( after 10 min ) can not be explained by either [5-lipoxygenase] or cyclooxygenase products but may be *mediated* directly by receptors . Positive_regulation ALOX5 LEO1 8666909 369190 Lipid body induction by *required* [5-lipoxygenase (LO)] activity and was inhibited by the 5-lipoxygenase activating protein antagonist MK 886 and the 5-LO inhibitor zileuton , but not by cyclooxygenase inhibitors . Positive_regulation ALOX5 LEO1 9516893 477390 These findings indicate that , in neutrophils from asthmatic patients , enhances LTB4 release and *increases* [5-lipoxygenase] activity and intracellular calcium to a greater extent than in neutrophils from non-asthmatic patients . Positive_regulation ALOX5 LPA 8002971 257863 Oxidized low density *increases* U937 cell [5-lipoxygenase] activity : induction of 5-lipoxygenase activating protein . Positive_regulation ALOX5 LTB 1314503 184998 To determine whether release by human alveolar macrophages following A23187 stimulation *required* the de novo production of [5-lipoxygenase] , alveolar macrophages were stimulated under conditions that would preclude a role for new enzyme production . Positive_regulation ALOX5 LTB 1330161 200129 5. The *induced* [5-LO] activation was effectively inhibited by MK-886 ( an inhibitor of 5-LO translocation ) , by pertussis toxin , and by the LTB4 receptor antagonist , LY-223982 . Positive_regulation ALOX5 MAP2K1 11091139 754760 inhibition *prevents* [5-lipoxygenase] translocation in N-formylpeptide challenged human neutrophils . Positive_regulation ALOX5 MAP2K1 11091139 754769 In order to elucidate the *role* of ( MEK-1/2 ) in [5-lipoxygenase (5-LO)] activation we studied the N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -induced 5-LO translocation in human blood neutrophils ( PMNs ) . Positive_regulation ALOX5 MAP2K1 19908283 2203549 The p38 mitogen activated protein kinase inhibitor , but not inhibitor , *reduced* the increase in [5-LO] in spinal microglia . Positive_regulation ALOX5 MAP2K1 8660693 367091 In Ca2+ ionophore activated HL-60 granulocytes the inhibitor , PD098059 , *blocked* translocation of [5-lipoxygenase] from the cytosol to the nuclear membrane and the corresponding enzyme activation . Positive_regulation ALOX5 MAP2K2 11091139 754761 inhibition *prevents* [5-lipoxygenase] translocation in N-formylpeptide challenged human neutrophils . Positive_regulation ALOX5 MAP2K2 11091139 754770 In order to elucidate the *role* of ( MEK-1/2 ) in [5-lipoxygenase (5-LO)] activation we studied the N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -induced 5-LO translocation in human blood neutrophils ( PMNs ) . Positive_regulation ALOX5 MAP2K2 19908283 2203550 The p38 mitogen activated protein kinase inhibitor , but not inhibitor , *reduced* the increase in [5-LO] in spinal microglia . Positive_regulation ALOX5 MAP2K2 8660693 367092 In Ca2+ ionophore activated HL-60 granulocytes the inhibitor , PD098059 , *blocked* translocation of [5-lipoxygenase] from the cytosol to the nuclear membrane and the corresponding enzyme activation . Positive_regulation ALOX5 MAP2K3 11091139 754771 In order to elucidate the *role* of ( MEK-1/2 ) in [5-lipoxygenase (5-LO)] activation we studied the N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -induced 5-LO translocation in human blood neutrophils ( PMNs ) . Positive_regulation ALOX5 MAP2K3 19908283 2203551 The p38 mitogen activated protein kinase inhibitor , but not inhibitor , *reduced* the increase in [5-LO] in spinal microglia . Positive_regulation ALOX5 MAP2K3 8660693 367093 In Ca2+ ionophore activated HL-60 granulocytes the inhibitor , PD098059 , *blocked* translocation of [5-lipoxygenase] from the cytosol to the nuclear membrane and the corresponding enzyme activation . Positive_regulation ALOX5 MAP2K4 11091139 754772 In order to elucidate the *role* of ( MEK-1/2 ) in [5-lipoxygenase (5-LO)] activation we studied the N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -induced 5-LO translocation in human blood neutrophils ( PMNs ) . Positive_regulation ALOX5 MAP2K4 19908283 2203552 The p38 mitogen activated protein kinase inhibitor , but not inhibitor , *reduced* the increase in [5-LO] in spinal microglia . Positive_regulation ALOX5 MAP2K4 8660693 367094 In Ca2+ ionophore activated HL-60 granulocytes the inhibitor , PD098059 , *blocked* translocation of [5-lipoxygenase] from the cytosol to the nuclear membrane and the corresponding enzyme activation . Positive_regulation ALOX5 MAP2K5 11091139 754773 In order to elucidate the *role* of ( MEK-1/2 ) in [5-lipoxygenase (5-LO)] activation we studied the N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -induced 5-LO translocation in human blood neutrophils ( PMNs ) . Positive_regulation ALOX5 MAP2K5 19908283 2203553 The p38 mitogen activated protein kinase inhibitor , but not inhibitor , *reduced* the increase in [5-LO] in spinal microglia . Positive_regulation ALOX5 MAP2K5 8660693 367095 In Ca2+ ionophore activated HL-60 granulocytes the inhibitor , PD098059 , *blocked* translocation of [5-lipoxygenase] from the cytosol to the nuclear membrane and the corresponding enzyme activation . Positive_regulation ALOX5 MAP2K6 11091139 754774 In order to elucidate the *role* of ( MEK-1/2 ) in [5-lipoxygenase (5-LO)] activation we studied the N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -induced 5-LO translocation in human blood neutrophils ( PMNs ) . Positive_regulation ALOX5 MAP2K6 19908283 2203554 The p38 mitogen activated protein kinase inhibitor , but not inhibitor , *reduced* the increase in [5-LO] in spinal microglia . Positive_regulation ALOX5 MAP2K6 8660693 367096 In Ca2+ ionophore activated HL-60 granulocytes the inhibitor , PD098059 , *blocked* translocation of [5-lipoxygenase] from the cytosol to the nuclear membrane and the corresponding enzyme activation . Positive_regulation ALOX5 MAP2K7 11091139 754775 In order to elucidate the *role* of ( MEK-1/2 ) in [5-lipoxygenase (5-LO)] activation we studied the N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -induced 5-LO translocation in human blood neutrophils ( PMNs ) . Positive_regulation ALOX5 MAP2K7 19908283 2203555 The p38 mitogen activated protein kinase inhibitor , but not inhibitor , *reduced* the increase in [5-LO] in spinal microglia . Positive_regulation ALOX5 MAP2K7 8660693 367097 In Ca2+ ionophore activated HL-60 granulocytes the inhibitor , PD098059 , *blocked* translocation of [5-lipoxygenase] from the cytosol to the nuclear membrane and the corresponding enzyme activation . Positive_regulation ALOX5 MAPK1 11807011 903491 In contrast , stress induced product formation and translocation of [5-LO] , as well as *activation* of p38 , occurred also after Ca ( ++ ) depletion . Positive_regulation ALOX5 MAPK1 19135147 2031997 Collectively , these data suggest that p38 *mediated* activation of [5-LO] by HNE might enhance CD36 expression , consequently leading to the formation of macrophage foam cells . Positive_regulation ALOX5 MAPK1 19908283 2203556 The p38 inhibitor , but not MEK inhibitor , *reduced* the increase in [5-LO] in spinal microglia . Positive_regulation ALOX5 MAPK10 11807011 903492 In contrast , stress induced product formation and translocation of [5-LO] , as well as *activation* of p38 , occurred also after Ca ( ++ ) depletion . Positive_regulation ALOX5 MAPK10 19135147 2031998 Collectively , these data suggest that p38 mediated *activation* of [5-LO] by HNE might enhance CD36 expression , consequently leading to the formation of macrophage foam cells . Positive_regulation ALOX5 MAPK10 19908283 2203557 The p38 inhibitor , but not MEK inhibitor , *reduced* the increase in [5-LO] in spinal microglia . Positive_regulation ALOX5 MAPK11 11807011 903493 In contrast , stress induced product formation and translocation of [5-LO] , as well as *activation* of p38 , occurred also after Ca ( ++ ) depletion . Positive_regulation ALOX5 MAPK11 19135147 2031999 Collectively , these data suggest that p38 *mediated* activation of [5-LO] by HNE might enhance CD36 expression , consequently leading to the formation of macrophage foam cells . Positive_regulation ALOX5 MAPK11 19908283 2203558 The p38 inhibitor , but not MEK inhibitor , *reduced* the increase in [5-LO] in spinal microglia . Positive_regulation ALOX5 MAPK12 11807011 903494 In contrast , stress induced product formation and translocation of [5-LO] , as well as *activation* of p38 , occurred also after Ca ( ++ ) depletion . Positive_regulation ALOX5 MAPK12 19135147 2032000 Collectively , these data suggest that p38 mediated *activation* of [5-LO] by HNE might enhance CD36 expression , consequently leading to the formation of macrophage foam cells . Positive_regulation ALOX5 MAPK12 19908283 2203559 The p38 inhibitor , but not MEK inhibitor , *reduced* the increase in [5-LO] in spinal microglia . Positive_regulation ALOX5 MAPK13 11807011 903495 In contrast , stress induced product formation and translocation of [5-LO] , as well as *activation* of p38 , occurred also after Ca ( ++ ) depletion . Positive_regulation ALOX5 MAPK13 19135147 2032001 Collectively , these data suggest that p38 *mediated* activation of [5-LO] by HNE might enhance CD36 expression , consequently leading to the formation of macrophage foam cells . Positive_regulation ALOX5 MAPK13 19908283 2203560 The p38 inhibitor , but not MEK inhibitor , *reduced* the increase in [5-LO] in spinal microglia . Positive_regulation ALOX5 MAPK14 11807011 903496 In contrast , stress induced product formation and translocation of [5-LO] , as well as *activation* of p38 , occurred also after Ca ( ++ ) depletion . Positive_regulation ALOX5 MAPK14 19135147 2032002 Collectively , these data suggest that p38 mediated *activation* of [5-LO] by HNE might enhance CD36 expression , consequently leading to the formation of macrophage foam cells . Positive_regulation ALOX5 MAPK14 19908283 2203561 The p38 inhibitor , but not MEK inhibitor , *reduced* the increase in [5-LO] in spinal microglia . Positive_regulation ALOX5 MAPK15 11807011 903490 In contrast , stress induced product formation and translocation of [5-LO] , as well as *activation* of p38 , occurred also after Ca ( ++ ) depletion . Positive_regulation ALOX5 MAPK15 19135147 2031995 Collectively , these data suggest that p38 *mediated* activation of [5-LO] by HNE might enhance CD36 expression , consequently leading to the formation of macrophage foam cells . Positive_regulation ALOX5 MAPK15 19908283 2203548 The p38 inhibitor , but not MEK inhibitor , *reduced* the increase in [5-LO] in spinal microglia . Positive_regulation ALOX5 MAPK3 11807011 903497 In contrast , stress induced product formation and translocation of [5-LO] , as well as *activation* of p38 , occurred also after Ca ( ++ ) depletion . Positive_regulation ALOX5 MAPK3 16998804 1666301 Hence , in addition to the previously characterised effects on cPLA(2) , critically *regulates* [5-LO] activity in the absence of additional downstream targets in the survival signalling preventing peroxynitrite toxicity . Positive_regulation ALOX5 MAPK3 19135147 2032003 Collectively , these data suggest that p38 *mediated* activation of [5-LO] by HNE might enhance CD36 expression , consequently leading to the formation of macrophage foam cells . Positive_regulation ALOX5 MAPK3 19908283 2203562 The p38 inhibitor , but not MEK inhibitor , *reduced* the increase in [5-LO] in spinal microglia . Positive_regulation ALOX5 MAPK4 11807011 903498 In contrast , stress induced product formation and translocation of [5-LO] , as well as *activation* of p38 , occurred also after Ca ( ++ ) depletion . Positive_regulation ALOX5 MAPK4 19135147 2032004 Collectively , these data suggest that p38 mediated *activation* of [5-LO] by HNE might enhance CD36 expression , consequently leading to the formation of macrophage foam cells . Positive_regulation ALOX5 MAPK4 19908283 2203563 The p38 inhibitor , but not MEK inhibitor , *reduced* the increase in [5-LO] in spinal microglia . Positive_regulation ALOX5 MAPK6 11807011 903499 In contrast , stress induced product formation and translocation of [5-LO] , as well as *activation* of p38 , occurred also after Ca ( ++ ) depletion . Positive_regulation ALOX5 MAPK6 19135147 2032005 Collectively , these data suggest that p38 *mediated* activation of [5-LO] by HNE might enhance CD36 expression , consequently leading to the formation of macrophage foam cells . Positive_regulation ALOX5 MAPK6 19908283 2203564 The p38 inhibitor , but not MEK inhibitor , *reduced* the increase in [5-LO] in spinal microglia . Positive_regulation ALOX5 MAPK7 11807011 903500 In contrast , stress induced product formation and translocation of [5-LO] , as well as *activation* of p38 , occurred also after Ca ( ++ ) depletion . Positive_regulation ALOX5 MAPK7 19135147 2032006 Collectively , these data suggest that p38 mediated *activation* of [5-LO] by HNE might enhance CD36 expression , consequently leading to the formation of macrophage foam cells . Positive_regulation ALOX5 MAPK7 19908283 2203565 The p38 inhibitor , but not MEK inhibitor , *reduced* the increase in [5-LO] in spinal microglia . Positive_regulation ALOX5 MAPK8 11807011 903501 In contrast , stress induced product formation and translocation of [5-LO] , as well as *activation* of p38 , occurred also after Ca ( ++ ) depletion . Positive_regulation ALOX5 MAPK8 19135147 2032007 Collectively , these data suggest that p38 *mediated* activation of [5-LO] by HNE might enhance CD36 expression , consequently leading to the formation of macrophage foam cells . Positive_regulation ALOX5 MAPK8 19908283 2203566 The p38 inhibitor , but not MEK inhibitor , *reduced* the increase in [5-LO] in spinal microglia . Positive_regulation ALOX5 MAPK9 11807011 903502 In contrast , stress induced product formation and translocation of [5-LO] , as well as *activation* of p38 , occurred also after Ca ( ++ ) depletion . Positive_regulation ALOX5 MAPK9 19135147 2032008 Collectively , these data suggest that p38 mediated *activation* of [5-LO] by HNE might enhance CD36 expression , consequently leading to the formation of macrophage foam cells . Positive_regulation ALOX5 MAPK9 19908283 2203567 The p38 inhibitor , but not MEK inhibitor , *reduced* the increase in [5-LO] in spinal microglia . Positive_regulation ALOX5 MET 8025123 263297 The soluble agonists and platelet activating factor *stimulated* [5-LO] activity , which peaked within 10 s and then rapidly declined . Positive_regulation ALOX5 NFKB1 10022882 590386 Reactive oxygen intermediate dependent activation by interleukin-1beta *requires* [5-lipoxygenase] or NADPH oxidase activity . Positive_regulation ALOX5 NFKB1 20554538 2327594 HNE induced [5-LO] expression is *regulated* by and Sp1/p38 MAPK pathways via EGF receptor in murine macrophages . Positive_regulation ALOX5 NFKB1 9535542 497059 The thickness and influx of neutrophils into the treated ears was measured as was the effects of the azaspiranes on [5-lipoxygenase] activity , cyclooxygenase activity , prostaglandin and leukotriene synthesis , and the *activation* of the transcription factor . Positive_regulation ALOX5 PAF1 1846895 153372 These results indicate that preincubation of peripheral blood neutrophils with GM-CSF enhances the ability of PAF to stimulate leukotriene synthesis by increasing both arachidonic acid availability and [5-lipoxygenase] activation in *response* to . Positive_regulation ALOX5 PAF1 8415804 234048 Although the early pulmonary vascular response ( < 10 min ) to PAF is dependent on cyclooxygenase products , the sustained response ( after 10 min ) can not be explained by either [5-lipoxygenase] or cyclooxygenase products but may be *mediated* directly by receptors . Positive_regulation ALOX5 PAF1 8666909 369188 Lipid body induction by *required* [5-lipoxygenase (LO)] activity and was inhibited by the 5-lipoxygenase activating protein antagonist MK 886 and the 5-LO inhibitor zileuton , but not by cyclooxygenase inhibitors . Positive_regulation ALOX5 PAF1 9516893 477388 These findings indicate that , in neutrophils from asthmatic patients , enhances LTB4 release and *increases* [5-lipoxygenase] activity and intracellular calcium to a greater extent than in neutrophils from non-asthmatic patients . Positive_regulation ALOX5 PARN 23642263 2795756 Recently , we have demonstrated that [5-LO] mRNA expression is *regulated* by alternative splicing and nonsense mediated ( NMD ) . Positive_regulation ALOX5 PGF 20448047 2275066 , elaborated from erythroid cells , *increased* the mRNA expression of [5-lipoxygenase] and 5-lipoxygenase activating protein ( FLAP ) in human pulmonary microvascular endothelial cells . Positive_regulation ALOX5 PLA2G1B 10856708 762271 The and PKC inhibitors effectively *inhibited* the chrysotile induced superoxide anion production of macrophages , but not the G-protein inhibitor , the [5-LO] and COX inhibitors , and the PAF antagonist . Positive_regulation ALOX5 PLA2G1B 18544894 1929094 Quinacrine , a inhibitor , indomethacin , and AA861 , a [5-lipoxygenase] *inhibitor* , inhibited the contraction . Positive_regulation ALOX5 PLA2G1B 19754384 2140388 In addition , novel substances such as HDL related agents , cyclopentenone prostaglandins , lipoprotein associated inhibitors , [5-lipoxygenase] pathway *inhibitors* , acyl CoA : cholesterol acyltransferase inhibitors , analogues of probucol and lysophosphatidic acid antagonists have been developed for the treatment of atherosclerosis as a consequence of their actions on oxidative stress and inflammation . Positive_regulation ALOX5 PLA2G1B 8189063 257001 Ag , but not , *induces* the translocation of [5-LO] to cellular membranes and the formation of 5-LO products . Positive_regulation ALOX5 PLD1 18218859 1884175 Tertiary-butanol , a rather poor inhibitor of , *caused* only moderate suppression of [5-LO] and hardly inhibited 5-LO translocation . Positive_regulation ALOX5 PLD2 18218859 1884176 Tertiary-butanol , a rather poor inhibitor of , *caused* only moderate suppression of [5-LO] and hardly inhibited 5-LO translocation . Positive_regulation ALOX5 PLD3 18218859 1884171 Tertiary-butanol , a rather poor inhibitor of , *caused* only moderate suppression of [5-LO] and hardly inhibited 5-LO translocation . Positive_regulation ALOX5 PLD4 18218859 1884172 Tertiary-butanol , a rather poor inhibitor of , *caused* only moderate suppression of [5-LO] and hardly inhibited 5-LO translocation . Positive_regulation ALOX5 PLD5 18218859 1884173 Tertiary-butanol , a rather poor inhibitor of , *caused* only moderate suppression of [5-LO] and hardly inhibited 5-LO translocation . Positive_regulation ALOX5 PLD6 18218859 1884174 Tertiary-butanol , a rather poor inhibitor of , *caused* only moderate suppression of [5-LO] and hardly inhibited 5-LO translocation . Positive_regulation ALOX5 PPARA 20400503 2282137 Subsequent studies show both in vitro and in a murine model of inflammation that [5-lipoxygenase] stimulation *induces* signaling and that this results specifically from production of the inflammatory mediator and chemoattractant leukotriene B ( 4 ) ( LTB ( 4 ) ) . Positive_regulation ALOX5 PPARG 11511519 851064 Additional experiments suggest that this involves the interplay of several factors , including the loss of growth stimulation by [5-LO] products , the induction of PPARg , and the potential *activation* of by interactions with shunted endoperoxides . Positive_regulation ALOX5 PRDX2 12817474 1103613 [5-Lipoxygenase (5-LO)] mRNA expression in Mono Mac 6 cells is *induced* by the histone deacetylase inhibitor . Positive_regulation ALOX5 PRDX2 12817474 1103614 Deletion of the five tandemized GC-boxes in the 5-LO reporter gene construct revealed that the *induction* of [5-LO] promoter activity by seems to be independent of these GC-boxes . Positive_regulation ALOX5 PRDX2 17894944 1802700 The histone deacetylase inhibitor potently *induces* [5-lipoxygenase (5-LO)] promoter activity in reporter gene assays as well as 5-LO mRNA expression . Positive_regulation ALOX5 PRDX2 21883892 2617018 We have previously shown that the histone deacetylase (HDAC) inhibitor *activates* [5-LO] transcription via recruitment of Sp1 , Sp3 and RNA polymerase II to the proximal promoter . Positive_regulation ALOX5 PRKACB 24486071 2938228 Impaired granulocyte function in AERD may *lead* to dysregulated control of [5-lipoxygenase] activity by PGE ( 2 ) , whereas adherent platelets lead to increased production of LTs , which contributes to the features of persistent respiratory tract inflammation and LT overproduction . Positive_regulation ALOX5 PRKACG 24486071 2938229 Impaired granulocyte function in AERD may *lead* to dysregulated control of [5-lipoxygenase] activity by PGE ( 2 ) , whereas adherent platelets lead to increased production of LTs , which contributes to the features of persistent respiratory tract inflammation and LT overproduction . Positive_regulation ALOX5 PRKAR1A 24486071 2938230 Impaired granulocyte function in AERD may *lead* to dysregulated control of [5-lipoxygenase] activity by PGE ( 2 ) , whereas adherent platelets lead to increased production of LTs , which contributes to the features of persistent respiratory tract inflammation and LT overproduction . Positive_regulation ALOX5 PRKAR1B 24486071 2938231 Impaired granulocyte function in AERD may *lead* to dysregulated control of [5-lipoxygenase] activity by PGE ( 2 ) , whereas adherent platelets lead to increased production of LTs , which contributes to the features of persistent respiratory tract inflammation and LT overproduction . Positive_regulation ALOX5 PRKAR2A 24486071 2938232 Impaired granulocyte function in AERD may *lead* to dysregulated control of [5-lipoxygenase] activity by PGE ( 2 ) , whereas adherent platelets lead to increased production of LTs , which contributes to the features of persistent respiratory tract inflammation and LT overproduction . Positive_regulation ALOX5 PRKAR2B 24486071 2938233 Impaired granulocyte function in AERD may *lead* to dysregulated control of [5-lipoxygenase] activity by PGE ( 2 ) , whereas adherent platelets lead to increased production of LTs , which contributes to the features of persistent respiratory tract inflammation and LT overproduction . Positive_regulation ALOX5 PRKG1 18474265 1927468 activation *resulted* in phosphorylation of [5-LO] . Positive_regulation ALOX5 PTGS2 17766677 1822814 Separate administration of 4-[5- ( 4-chlorophenyl ) -3- ( trifluoromethyl ) -1H-pyrazol-1-yl ] benzenesulfonamide ( SC-236 ) , a selective inhibitor , and CJ-13,610 , a [5-LO] *inhibitor* , to carbon tetrachloride treated mice significantly reduced fibrosis as revealed by the analysis of Sirius Red stained liver sections without affecting necroinflammation . Positive_regulation ALOX5 PTGS2 21067431 2349578 We hypothesized that [5-LO] is a negative regulator of fracture healing and that in the absence of , excess leukotrienes synthesized by 5-LO will *impair* fracture healing . Positive_regulation ALOX5 RAC1 11374881 817933 and p38 kinase *mediate* [5-lipoxygenase] translocation and cell death . Positive_regulation ALOX5 RAC1 12038964 984311 Consistent with those findings , Abeta ( 25-35 ) *stimulated* translocation of [5-LO] to the nuclear envelope and increased intracellular levels of leukotriene B ( 4 ) , while exogenous application of leukotriene B ( 4 ) increased intracellular H ( 2 ) O ( 2 ) via BLT , its cell-surface receptor . Positive_regulation ALOX5 RAC2 11374881 817934 and p38 kinase *mediate* [5-lipoxygenase] translocation and cell death . Positive_regulation ALOX5 RAC2 12038964 984312 Consistent with those findings , Abeta ( 25-35 ) *stimulated* translocation of [5-LO] to the nuclear envelope and increased intracellular levels of leukotriene B ( 4 ) , while exogenous application of leukotriene B ( 4 ) increased intracellular H ( 2 ) O ( 2 ) via BLT , its cell-surface receptor . Positive_regulation ALOX5 RAC3 11374881 817935 and p38 kinase *mediate* [5-lipoxygenase] translocation and cell death . Positive_regulation ALOX5 RAC3 12038964 984313 Consistent with those findings , Abeta ( 25-35 ) *stimulated* translocation of [5-LO] to the nuclear envelope and increased intracellular levels of leukotriene B ( 4 ) , while exogenous application of leukotriene B ( 4 ) increased intracellular H ( 2 ) O ( 2 ) via BLT , its cell-surface receptor . Positive_regulation ALOX5 RBBP4 25402609 2960352 Surprisingly , a constitutive activation of [ALOX5] by MLL-AF4 was *inhibited* by class I inhibitors , by relieving inhibitory functions deriving from MLL . Positive_regulation ALOX5 RBBP7 25402609 2960353 Surprisingly , a constitutive activation of [ALOX5] by MLL-AF4 was *inhibited* by class I inhibitors , by relieving inhibitory functions deriving from MLL . Positive_regulation ALOX5 RBL1 12525578 1048065 We show that stimulation of polymorphonuclear leukocytes ( PMNL ) , , or transfected HeLa cells with arachidonic acid ( AA ) *caused* prominent [5-LO] product formation that coincided with the activity of extracellular signal regulated kinases ( ERKs ) and p38 mitogen activated protein kinase . Positive_regulation ALOX5 RELA 10022882 590387 Reactive oxygen intermediate dependent activation by interleukin-1beta *requires* [5-lipoxygenase] or NADPH oxidase activity . Positive_regulation ALOX5 RELA 20554538 2327595 HNE induced [5-LO] expression is *regulated* by and Sp1/p38 MAPK pathways via EGF receptor in murine macrophages . Positive_regulation ALOX5 RELA 9535542 497060 The thickness and influx of neutrophils into the treated ears was measured as was the effects of the azaspiranes on [5-lipoxygenase] activity , cyclooxygenase activity , prostaglandin and leukotriene synthesis , and the *activation* of the transcription factor . Positive_regulation ALOX5 RUNX1 24130502 2853290 Here we show that , the leukemogenic alternatively spliced transcript expressed from t ( 8 ; 21 ) , *upregulates* target gene [Alox5] , which is a gene critically required for the promotion of chronic myeloid leukemia development by BCR-ABL. Loss of Alox5 expression reduces activity of RUNX1-ETO9a , MLL-AF9 and PML-RARa in vitro . Positive_regulation ALOX5 RUNX1 24130502 2853291 Finally , we demonstrate that the *upregulation* of [Alox5] by occurs via the C2H2 zinc finger transcription factor KLF6 , a protein required for early hematopoiesis and yolk sac development . Positive_regulation ALOX5 SDS 11642042 872201 We have studied the sizes and shapes of mixed micelles Lubrol PX/linoleic acid ( aggregates type 1 ) and Lubrol PX/linoleic acid/SDS ( aggregates type 2 ; was an effective *activator* of potato tuber [5-lipoxygenase] ) by means of gel-filtration and laser light scattering techniques . Positive_regulation ALOX5 SP1 20554538 2327600 Moreover , the *role* of and NF-?B in HNE induced [5-LO] expression was confirmed by siRNA knockdown of Sp1 and NF-?B . Positive_regulation ALOX5 SP3 17894944 1802739 This is the first report demonstrating that is *involved* in the regulation of [5-LO] promoter activity . Positive_regulation ALOX5 TGFB1 11090070 754425 further *increased* [5-LO] and FLAP expression , recruited additional cells into the 5-LO ( + ) DC population , and promoted production of 5-hydroxyeicosatetraenoic acid and leukotriene B ( 4 ) in response to calcium ( Ca ( ++ ) ) ionophore A23187 . Positive_regulation ALOX5 TGFB1 16750418 1590048 1,25-Dihydroxyvitamin D ( 3 ) ( 1,25 ( OH ) ( 2 ) D ( 3 ) ) and ( TGFbeta ) potently *induce* [5-lipoxygenase (5-LO)] in myeloid cells . Positive_regulation ALOX5 TGFB1 16919603 1608616 [5-Lipoxygenase (5-LO)] expression is strongly *induced* by ( TGFbeta ) and 1alpha,25-dihydroxyvitamin D ( 3 ) in Mono Mac 6 cells . Positive_regulation ALOX5 TGFB1 7816797 292865 Sequential *induction* of [5-lipoxygenase] gene expression and activity in Mono Mac 6 cells by and 1,25-dihydroxyvitamin D3 . Positive_regulation ALOX5 TGFB1 8327471 223448 *upregulates* [5-lipoxygenase] activity during myeloid cell maturation . Positive_regulation ALOX5 TGFB1 8327471 223451 ( TGF beta ) *increased* the [arachidonate 5-lipoxygenase] ( 5-LO ; EC 1 .13.11.34 ) activity in HL-60 cells induced to granulocytic differentiation by dimethyl sulfoxide . Positive_regulation ALOX5 TGFB2 16750418 1590049 1,25-Dihydroxyvitamin D ( 3 ) ( 1,25 ( OH ) ( 2 ) D ( 3 ) ) and ( TGFbeta ) potently *induce* [5-lipoxygenase (5-LO)] in myeloid cells . Positive_regulation ALOX5 TGFB2 16919603 1608617 [5-Lipoxygenase (5-LO)] expression is strongly *induced* by ( TGFbeta ) and 1alpha,25-dihydroxyvitamin D ( 3 ) in Mono Mac 6 cells . Positive_regulation ALOX5 TGFB2 7816797 292866 Sequential *induction* of [5-lipoxygenase] gene expression and activity in Mono Mac 6 cells by and 1,25-dihydroxyvitamin D3 . Positive_regulation ALOX5 TGFB2 8327471 223449 *upregulates* [5-lipoxygenase] activity during myeloid cell maturation . Positive_regulation ALOX5 TGFB2 8327471 223452 ( TGF beta ) *increased* the [arachidonate 5-lipoxygenase] ( 5-LO ; EC 1 .13.11.34 ) activity in HL-60 cells induced to granulocytic differentiation by dimethyl sulfoxide . Positive_regulation ALOX5 TGFB3 16750418 1590050 1,25-Dihydroxyvitamin D ( 3 ) ( 1,25 ( OH ) ( 2 ) D ( 3 ) ) and ( TGFbeta ) potently *induce* [5-lipoxygenase (5-LO)] in myeloid cells . Positive_regulation ALOX5 TGFB3 16919603 1608618 [5-Lipoxygenase (5-LO)] expression is strongly *induced* by ( TGFbeta ) and 1alpha,25-dihydroxyvitamin D ( 3 ) in Mono Mac 6 cells . Positive_regulation ALOX5 TGFB3 7816797 292867 Sequential *induction* of [5-lipoxygenase] gene expression and activity in Mono Mac 6 cells by and 1,25-dihydroxyvitamin D3 . Positive_regulation ALOX5 TGFB3 8327471 223450 *upregulates* [5-lipoxygenase] activity during myeloid cell maturation . Positive_regulation ALOX5 TGFB3 8327471 223453 ( TGF beta ) *increased* the [arachidonate 5-lipoxygenase] ( 5-LO ; EC 1 .13.11.34 ) activity in HL-60 cells induced to granulocytic differentiation by dimethyl sulfoxide . Positive_regulation ALOX5 TNF 11090070 754420 Granulocyte-macrophage colony stimulating factor ( GM-CSF ) plus promoted DC differentiation and *induced* a strong rise in [5-LO] and FLAP expression . Positive_regulation ALOX5 TNF 22608768 2681540 Lipopolysaccharides , TNF , IL-1a , and the reagents combination increased PTGS2 , PTGES , and PGFS mRNA transcription ( P < 0.01 ) , whereas [ALOX5] mRNA transcription was *increased* only by ( P < 0.001 ) . Positive_regulation ALOX5 UPF1 23642263 2795758 Recently , we have demonstrated that [5-LO] mRNA expression is *regulated* by alternative splicing and nonsense mediated ( NMD ) . Positive_regulation ALOX5 UPF2 23642263 2795751 Recently , we have demonstrated that [5-LO] mRNA expression is *regulated* by alternative splicing and nonsense mediated ( NMD ) . Positive_regulation ALOX5 UPF3B 23642263 2795753 Recently , we have demonstrated that [5-LO] mRNA expression is *regulated* by alternative splicing and nonsense mediated ( NMD ) . Positive_regulation ALOX5 WDR61 1846895 153373 These results indicate that preincubation of peripheral blood neutrophils with GM-CSF enhances the ability of PAF to stimulate leukotriene synthesis by increasing both arachidonic acid availability and [5-lipoxygenase] activation in *response* to . Positive_regulation ALOX5 WDR61 8415804 234049 Although the early pulmonary vascular response ( < 10 min ) to PAF is dependent on cyclooxygenase products , the sustained response ( after 10 min ) can not be explained by either [5-lipoxygenase] or cyclooxygenase products but may be *mediated* directly by receptors . Positive_regulation ALOX5 WDR61 8666909 369189 Lipid body induction by *required* [5-lipoxygenase (LO)] activity and was inhibited by the 5-lipoxygenase activating protein antagonist MK 886 and the 5-LO inhibitor zileuton , but not by cyclooxygenase inhibitors . Positive_regulation ALOX5 WDR61 9516893 477389 These findings indicate that , in neutrophils from asthmatic patients , enhances LTB4 release and *increases* [5-lipoxygenase] activity and intracellular calcium to a greater extent than in neutrophils from non-asthmatic patients . Positive_regulation ALOX5 XRN1 23642263 2795755 Recently , we have demonstrated that [5-LO] mRNA expression is *regulated* by alternative splicing and nonsense mediated ( NMD ) . Positive_regulation ALOX5 XRN2 23642263 2795749 Recently , we have demonstrated that [5-LO] mRNA expression is *regulated* by alternative splicing and nonsense mediated ( NMD ) . Positive_regulation ALOX5AP ALOX5 16677242 1558947 Antibodies against the following enzymes were also used : cyclo-oxygenase ( COX-1 , COX-2 ) , 5-lipoxygenase (5-LO) , <5-lipoxygenase> *activating* factor ( [FLAP] ) , LTA4 hydrolase (LTA4h) and LTC4 synthase (LTC4s) . Positive_regulation ALOX5AP PLAT 17330201 1707349 *Role* of recombinant in free [flap] salvage . Positive_regulation ALOX5AP TNF 11090070 754422 Granulocyte-macrophage colony stimulating factor ( GM-CSF ) plus promoted DC differentiation and *induced* a strong rise in 5-LO and [FLAP] expression . Positive_regulation ALOX5AP TNF 12571239 1079245 We conclude that the FLAP gene is transactivated by members of the C/EBP family of transcription factors in inflammatory cells and that these factors play an important role in [FLAP] gene *induction* by . Positive_regulation ALPI TNF 22301394 2570940 Furthermore , the expression of antiapoptotic proteins ( [IAP1] , IAP2 , and Bcl-X ( L ) ) was *up-regulated* by and suppressed by CPT in HaCaT cells . Positive_regulation AMELX JAG1 11911862 924256 The present study examined changes in chronically recorded extracellular neuronal firing patterns in the lateral nucleus of [AMG] ( LAMG ) *induced* by kindling in behaving genetically epilepsy-prone rats ( GEPR-9s ) . Positive_regulation AMH IGFBP1 21931746 2479766 Morpholino knockdown of IGFBP-1 rescued the PGC migration defect phenotype in hypoxic embryos , suggesting the *role* of in inducing PGC [mis-migration] . Positive_regulation AMH RNF150 11108557 756892 Non-ovarian tissues failed to produce [MIS] in *response* to . Positive_regulation AMOTL1 TNF 23793505 2828620 IFN-? pretreatment diminished the *induced* [AmotL1] in the cultured HLMVECs by blocking the degradation of I?Ba . Positive_regulation AMOTL1 TNF 23793505 2828621 These results suggested that IFN-? exhibits anti-angiogenesis effects by regulating the expression of *induced* [AmotL1] via NF?B in emphysema lungs . Positive_regulation AMPH CAPN8 17541403 1762502 These results suggest that *dependent* cleavage of [amphiphysin] I inhibits synaptic vesicle endocytosis during neural hyperexcitation and demonstrate a novel post-translational regulation of endocytosis . Positive_regulation AMPH SYT8 10792432 689295 Subsequently , [amphiphysin] immunoreactivity *follows* the expression of and synaptic vesicle protein 2 (SV2) as seen in the retina and the tectum , and exhibits the same staining as the other proteins in the mature chick brain . Positive_regulation ANG ANGPT1 2406198 128068 After captopril , plasma [angiotensin II (Ang II)] levels were decreased and levels *increased* in the two groups . Positive_regulation ANG CTGF 17318787 1664879 We have evaluated the *role* of in vascular and renal damage associated with hypertension and possible interactions with [angiotensin II (Ang II)] . Positive_regulation ANG CTGF 20035857 2217851 [Angiotensin (ANG)] II may *induce* expression in the heart and kidney and plays an important role in the pathogenesis of lung fibrosis . Positive_regulation ANG EDN2 16989616 1617946 We demonstrated that allostimulation *induced* EDN , RNase A , and [angiogenin] mRNA expression in peripheral blood mononuclear cells ( PBMCs ) , although only protein was detected . Positive_regulation ANG IL1B 10999742 734344 In an in vitro study , and tumor necrosis factor-alpha *induced* [angiogenin] mRNA expression in colon cancer cells in a dose- and time dependent manner , and these cytokines significantly upregulated the expression of angiogenin mRNA , especially in colon cancer cells rather than in other cells in the stroma of tumor tissues ( fibroblasts , tumor infiltrating lymphocytes , macrophages ) . Positive_regulation ANG IL1B 12802423 1101306 [Angiogenin] isolated from cow milk *induces* the production of cytokines , IL-6 , and TNF-alpha in human leukocytes ; Positive_regulation ANG MAP2K6 12225947 987902 Although an inhibitor of , PD-98059 , but not rapamycin , *blocked* [ANG] IV-induced phosphorylation of ERK1/2 , both PD-98059 and rapamycin independently caused partial reduction in ANG IV-mediated cell proliferation . Positive_regulation ANG PLAT 7991590 282951 Binding of angiogenin to its cell-surface binding protein ( actin ) followed by dissociation of the [angiogenin-actin] complex from the cell surface and subsequent *activation* of are likely steps involved in the processes of endothelial cell invasion and angiogenesis . Positive_regulation ANG PLAU 21389187 2416202 From the angiogenesis antibody array analysis , we observed that the simultaneous downregulation of uPAR and *resulted* in the downregulation of [angiogenin] and overexpression of RANTES . Positive_regulation ANG TNF 10999742 734343 In an in vitro study , interleukin-1beta and *induced* [angiogenin] mRNA expression in colon cancer cells in a dose- and time dependent manner , and these cytokines significantly upregulated the expression of angiogenin mRNA , especially in colon cancer cells rather than in other cells in the stroma of tumor tissues ( fibroblasts , tumor infiltrating lymphocytes , macrophages ) . Positive_regulation ANG TNF 12802423 1101305 [Angiogenin] isolated from cow milk *induces* the production of cytokines IL-1beta , IL-6 , and in human leukocytes ; Positive_regulation ANG TNF 18292388 1896630 [Angiotensin II (Ang II)] and levels *increase* endothelial permeability , and we hypothesized that adiponectin suppressed these responses in a cAMP dependent manner . Positive_regulation ANGPT1 ACE 12359982 994886 Circulating ( pro ) renin , angiotensinogen , [ANG I] and ANG II enter the interstitium via diffusion , and interstitial ANG II generation is *mediated* , at least in part , by basolaterally located endothelial . Positive_regulation ANGPT1 ACE 1708902 155188 These findings indicate that intrarenal conversion of ANG I to ANG II occurs , at least in part , at a site which is inaccessible to acutely administered ACE inhibitors , or that there is an alternative pathway for the intrarenal conversion of [ANG I] to ANG II that is not *blocked* by inhibitors . Positive_regulation ANGPT1 ACE 19578709 2104850 Within the kidneys , Ang- ( 1-7 ) is generated by *mediated* degradation of Ang II , sequential cleavage of the precursor angiotensin I (Ang I) by ACE2 and ACE , or the actions of brush-border membrane peptidases on [Ang I] . Positive_regulation ANGPT1 ACE2 15467007 1359220 ACE2 is expressed in the kidney , but its precise intrarenal localization is unclear , and the *role* of intrarenal in the production of [ANG 1-7] is unknown . Positive_regulation ANGPT1 ACE2 15467007 1359222 The data suggest that *mediated* production of [ANG 1-7] represents an important component of the proximal tubular renin-ANG system . Positive_regulation ANGPT1 ACE2 19934006 2198226 Human recombinant *increased* [ANG 1-7] levels , lowered ANG II levels , and reduced NADPH oxidase activity . Positive_regulation ANGPT1 ACE2 22018415 2513612 in syncytiotrophoblasts could *regulate* release of [Ang 1-7] into the maternal circulation contributing to the vasodilation of the maternal vasculature . Positive_regulation ANGPT1 ANG 2406198 128069 After captopril , plasma levels were decreased and [Ang I] levels *increased* in the two groups . Positive_regulation ANGPT1 ANGPT2 1312512 182308 *stimulated* renin production in a dose dependent fashion ( cell-active renin , 1.21 +/- 0.20 to 2.39 +/- 0.16 ; medium-inactive renin , 2.59 +/- 0.40 to 6.14 +/- 0.49 ng [Ang I/10] ( 6 ) cells ) . Positive_regulation ANGPT1 ANGPT2 16814127 1580794 The increase of VEGF induced by ang II was suppressed by losartan , and the increase of [Ang1] *induced* by was inhibited by PD123319 as detected by immunoblot . Positive_regulation ANGPT1 ANGPT2 17341311 1712271 Our results suggest that although both Ang1 and can *activate* the Tie-2 receptor in bmLECs , [Ang1] and Ang2 may have distinct roles in mesenteric lymphatic endothelial cells . Positive_regulation ANGPT1 ANGPT2 18310225 1897437 We conclude that in vivo endotoxemia triggers functional inhibition of the Ang-1/Tie-2 receptor pathway by reducing [Ang-1] and Tie-2 expression and *inducing* levels and that this response may contribute to enhanced vascular leakage in sepsis . Positive_regulation ANGPT1 ANGPT2 19160387 2032403 In NPs , VEGF and [Ang-1] were *detected* in glandular epithelial , vascular endothelial , as well as stromal inflammatory cells , whereas was detected only in stromal inflammatory cells . Positive_regulation ANGPT1 ANGPT2 24156373 2882733 Serum Ang-1 and levels were constant throughout COS , but serum [Ang-1] levels were *increased* at all time points in PCOS women compared with controls ( p < 0.05 ) . Positive_regulation ANGPT1 ANGPT2 8023987 263276 These results demonstrate that [ANG I] , II , and III have similar pulmonary pressor activity and that responses are *mediated* by type 1 receptors . Positive_regulation ANGPT1 APC 21173154 2390937 Interestingly , did not *activate* Tie2 through its major ligand , [angiopoietin-1] , but instead acted by binding to endothelial protein C receptor , cleaving protease activated receptor-1 and transactivating EGF receptor . Positive_regulation ANGPT1 APOE 12958144 1143317 Ang-4 was also *induced* by hypoxia or in human cardiac cells , whereas [Ang-1] expression remained unchanged . Positive_regulation ANGPT1 BMPR2 23676498 2791571 Absence of signaling in the uterine decidua consequently *suppressed* IL-15 , VEGF , [angiopoietin] , and corin signaling . Positive_regulation ANGPT1 CCL21 21225692 2408986 CCL19 and activation *induced* vascular endothelial growth factor and angiotensin I (Ang I) production in RA ST fibroblasts and secretion of IL-8 and [Ang I] from macrophages . Positive_regulation ANGPT1 CLEC11A 20066899 2177702 While no effects on the proangiogenic factors VEGF or IL-8 were noted , the expression of [angiopoietins (Ang) 1] and 4 were *increased* by the , but not by the p33ING1b isoform . Positive_regulation ANGPT1 COL3A1 17906098 1830124 [LV-ANG I-converting] enzyme activity increased ( 28 % ) in the S group ( 33 % ) , and synthesis *increased* ( 56 % ) in T+S but not in T group . Positive_regulation ANGPT1 CTSD 12811821 1102917 Expression of alpha-smooth muscle ( SM ) actin , apparent in the contractile phenotype , was decreased by FN. Expressions of matrix Gla and osteopontin , apparent in the synthetic phenotype , were increased by FN . Ang II measured by radioimmunoassay ( RIA ) was significantly increased in human VSMC by FN. Expression of mRNAs for Ang II-generating proteases cathepsin D , cathepsin G , ACE , and chymase was increased by FN. Expressions of and cathepsin G proteins were also *increased* by FN. [Ang I-generating] activity , which was inhibited by an aspartyl protease inhibitor pepstatin A , was readily detected in the conditioned medium from human VSMC . Positive_regulation ANGPT1 DKK3 23765731 2823908 promotes fibroblast proliferation and myofibroblast differentiation and *regulates* expression of [angiopoietin-1] in prostatic stroma potentially via enhancing PI3K/AKT signaling . Positive_regulation ANGPT1 DLL4 17478063 1766576 at all concentrations tested did not *increase* [Angiopoietin-1] . Positive_regulation ANGPT1 DLL4 17478063 1766577 did not *stimulate* [Angiopoietin-1] , while the other steroids had differential effects greater than control . Positive_regulation ANGPT1 DUSP1 24308939 2877821 [Ang-1] differentially *induces* , DUSP4 , and DUSP5 in human umbilical vein endothelial cells through activation of the PI-3 kinase , ERK1/2 , p38 , and SAPK/JNK pathways . Positive_regulation ANGPT1 DUSP4 24308939 2877822 [Ang-1] differentially *induces* DUSP1 , , and DUSP5 in human umbilical vein endothelial cells through activation of the PI-3 kinase , ERK1/2 , p38 , and SAPK/JNK pathways . Positive_regulation ANGPT1 DUSP5 24308939 2877823 [Ang-1] differentially *induces* DUSP1 , DUSP4 , and in human umbilical vein endothelial cells through activation of the PI-3 kinase , ERK1/2 , p38 , and SAPK/JNK pathways . Positive_regulation ANGPT1 ELF3 14715662 1219537 ESE-1 and [Ang-1] are *induced* in synovial fibroblasts in response to inflammatory cytokines , with induction slightly preceding that of Ang-1 . Positive_regulation ANGPT1 ELF3 14715662 1219539 Mutation of a high-affinity ESE-1 binding site leads to a marked reduction in [Ang-1] *transactivation* by , inducibility by inflammatory cytokines , and DNA binding to the ESE-1 protein . Positive_regulation ANGPT1 ENPEP 6129208 23689 *initiating* the breakdown of [ANG I] and II , and APM possibly continuing it in sequential fashion . Positive_regulation ANGPT1 EPOR 15531367 1332906 Moreover , [Ang-1] expression is *regulated* by under normoxic conditions . Positive_regulation ANGPT1 EPX 15531367 1332907 Moreover , [Ang-1] expression is *regulated* by under normoxic conditions . Positive_regulation ANGPT1 FGA 19052021 2047395 *induced* the production of interleukin 6 (IL6) , interleukin 8 (IL8) , monocyte chemoattractant protein-1 , vascular endothelial growth factor , [angiopoietin-1] and type I collagen , but not proliferation or intercellular adhesion molecule-1 expression . Positive_regulation ANGPT1 FGG 19052021 2047396 *induced* the production of interleukin 6 (IL6) , interleukin 8 (IL8) , monocyte chemoattractant protein-1 , vascular endothelial growth factor , [angiopoietin-1] and type I collagen , but not proliferation or intercellular adhesion molecule-1 expression . Positive_regulation ANGPT1 HIF1A 12958144 1143316 Ang-4 was also *induced* by hypoxia or in human cardiac cells , whereas [Ang-1] expression remained unchanged . Positive_regulation ANGPT1 HP 23274064 2737567 Lack of *results* in unbalanced [VEGFa/angiopoietin-1] expression , intramural hemorrhage and impaired wound healing after myocardial infarction . Positive_regulation ANGPT1 IFNB1 17579115 1763949 Induction of [angiopoietin-1] expression in *response* to was broadly observed in different tumor lines but not in those with defects in IFN signaling . Positive_regulation ANGPT1 IFNG 17466926 1731957 Although stimulation with TNF-alpha or *had* little or no effect on [Ang-1] secretion , costimulation with IFN-gamma plus TNF-alpha dose- and time-dependently diminished secretion of Ang-1 from hOBs . Positive_regulation ANGPT1 IL10 21550286 2562154 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL11 21550286 2562155 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL13 21550286 2562156 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL15 21550286 2562157 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL16 21550286 2562158 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL18 21550286 2562159 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL19 21550286 2562160 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL1A 21550286 2562175 This study aimed to identify the regulatory effect of tacrolimus on the *induced* expressions of [angiopoietin-1 (Ang-1)] , Tie-2 receptor ( Tie-2 ) , and vascular endothelial growth factor ( VEGF ) in human rheumatoid fibroblast-like synoviocytes ( FLS ) and to determine the regulatory mechanism in the mitogen activated protein kinases ( MAPKs ) signaling pathway . Positive_regulation ANGPT1 IL1A 21550286 2562178 *induced* [Ang-1] , Tie-2 , and VEGF expressions with and without tacrolimus were measured in cultured FLS using real time-polymerase chain reaction , enzyme linked immunosorbent assay , Western blotting , and immunofluorescence staining . Positive_regulation ANGPT1 IL1B 15126358 1244838 *regulates* [angiopoietin-1] expression in human endothelial cells . Positive_regulation ANGPT1 IL1B 16565972 1549861 *regulated* VEGF-A and [Ang-1] expressions in a dose dependent manner . Positive_regulation ANGPT1 IL2 21550286 2562161 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL20 21550286 2562162 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL21 21550286 2562163 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL22 21550286 2562146 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL24 21550286 2562144 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL25 21550286 2562145 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL26 21550286 2562150 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL27 21550286 2562151 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL3 21550286 2562164 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL31 21550286 2562152 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL32 21550286 2562149 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL33 21550286 2562148 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL34 21550286 2562153 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL37 21550286 2562147 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL4 21550286 2562165 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL5 21550286 2562166 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL6 21550286 2562167 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL7 21550286 2562168 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL8 21550286 2562169 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 IL8 22015631 2585096 [Angiopoietin-1] but not angiopoietin-2 *induces* synthesis and release by human neutrophils . Positive_regulation ANGPT1 IL9 21550286 2562170 Tacrolimus ( FK506 ) inhibits *induced* [angiopoietin-1] , Tie-2 receptor , and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes . Positive_regulation ANGPT1 ING1 20066899 2177703 While no effects on the proangiogenic factors VEGF or IL-8 were noted , the expression of [angiopoietins (Ang) 1] and 4 were *increased* by the , but not by the p33ING1b isoform . Positive_regulation ANGPT1 IQGAP1 21885850 2496452 Further , our data show that [Angpt-1] *requires* as an indispensable activator of Rac1 . Positive_regulation ANGPT1 KDR 17525262 1746181 Migration of human HSC/MFs under hypoxic conditions involved up-regulation of VEGF-A , [Ang-1] , and related receptors and was mainly *dependent* on ( Flk-1 ) . Positive_regulation ANGPT1 KLF2 19106103 2036472 Here , we investigated the mechanism of how Ang1/Tie2 signal induces KLF2 expression to clarify the *role* of in [Ang1/Tie2] signal mediated vascular quiescence . Positive_regulation ANGPT1 LEP 16317688 1487643 also *increased* gene expression of the proangiogenic cytokines vascular endothelial growth factor ( VEGF ) and [angiopoietin-1] , and VEGF was also upregulated at the protein level . Positive_regulation ANGPT1 MAP2K4 16000309 1452802 In addition , [Ang1] *induced* phosphorylation at Ser80 , suggesting the existence of an additional signal transduction pathway through which Ang1 attenuates JNK phosphorylation . Positive_regulation ANGPT1 MAPK1 12213710 985620 Both VEGF and [Ang-1] *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 . Positive_regulation ANGPT1 MAPK1 12213726 985677 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of [Ang-1] and Ang-2 as well as the *activation* of , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation ANGPT1 MAPK1 20079751 2212518 By contrast , [Ang1] *activation* of signaling was not affected by hyperglycemia . Positive_regulation ANGPT1 MAPK1 22508858 2613298 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Positive_regulation ANGPT1 MAPK10 12213710 985621 Both VEGF and [Ang-1] *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 . Positive_regulation ANGPT1 MAPK10 12213726 985678 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of [Ang-1] and Ang-2 as well as the *activation* of , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation ANGPT1 MAPK10 22508858 2613299 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Positive_regulation ANGPT1 MAPK11 12213710 985622 Both VEGF and [Ang-1] *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 . Positive_regulation ANGPT1 MAPK11 12213726 985679 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of [Ang-1] and Ang-2 as well as the *activation* of , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation ANGPT1 MAPK11 22508858 2613300 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Positive_regulation ANGPT1 MAPK12 12213710 985623 Both VEGF and [Ang-1] *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 . Positive_regulation ANGPT1 MAPK12 12213726 985680 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of [Ang-1] and Ang-2 as well as the *activation* of , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation ANGPT1 MAPK12 22508858 2613301 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Positive_regulation ANGPT1 MAPK13 12213710 985624 Both VEGF and [Ang-1] *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 . Positive_regulation ANGPT1 MAPK13 12213726 985681 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of [Ang-1] and Ang-2 as well as the *activation* of , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation ANGPT1 MAPK13 22508858 2613302 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Positive_regulation ANGPT1 MAPK14 12213710 985625 Both VEGF and [Ang-1] *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 . Positive_regulation ANGPT1 MAPK14 12213726 985682 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of [Ang-1] and Ang-2 as well as the *activation* of , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation ANGPT1 MAPK14 22508858 2613303 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Positive_regulation ANGPT1 MAPK15 12213710 985619 Both VEGF and [Ang-1] *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 . Positive_regulation ANGPT1 MAPK15 12213726 985676 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of [Ang-1] and Ang-2 as well as the *activation* of , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation ANGPT1 MAPK15 22508858 2613297 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Positive_regulation ANGPT1 MAPK3 12213710 985626 Both VEGF and [Ang-1] *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 . Positive_regulation ANGPT1 MAPK3 12213726 985683 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of [Ang-1] and Ang-2 as well as the *activation* of , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation ANGPT1 MAPK3 12824293 1113658 We conclude that both anti- ( ERK1/2 ) and pro- ( p38 ) apoptotic members of MAPKs are simultaneously activated by Ang-1 in endothelial cells and that *activation* of by [Ang-1] is mediated through the PI-3 kinase pathway . Positive_regulation ANGPT1 MAPK3 20079751 2212519 By contrast , [Ang1] *activation* of signaling was not affected by hyperglycemia . Positive_regulation ANGPT1 MAPK3 22508858 2613304 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either ( ERK1/2 ) , p38 MAPK , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Positive_regulation ANGPT1 MAPK4 12213710 985627 Both VEGF and [Ang-1] *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 . Positive_regulation ANGPT1 MAPK4 12213726 985684 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of [Ang-1] and Ang-2 as well as the *activation* of , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation ANGPT1 MAPK4 22508858 2613305 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Positive_regulation ANGPT1 MAPK6 12213710 985628 Both VEGF and [Ang-1] *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 . Positive_regulation ANGPT1 MAPK6 12213726 985685 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of [Ang-1] and Ang-2 as well as the *activation* of , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation ANGPT1 MAPK6 22508858 2613306 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Positive_regulation ANGPT1 MAPK7 12213710 985629 Both VEGF and [Ang-1] *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 . Positive_regulation ANGPT1 MAPK7 12213726 985686 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of [Ang-1] and Ang-2 as well as the *activation* of , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation ANGPT1 MAPK7 22508858 2613307 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Positive_regulation ANGPT1 MAPK8 12213710 985630 Both VEGF and [Ang-1] *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 . Positive_regulation ANGPT1 MAPK8 12213726 985687 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of [Ang-1] and Ang-2 as well as the *activation* of , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation ANGPT1 MAPK8 22508858 2613308 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Positive_regulation ANGPT1 MAPK9 12213710 985631 Both VEGF and [Ang-1] *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 . Positive_regulation ANGPT1 MAPK9 12213726 985688 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of [Ang-1] and Ang-2 as well as the *activation* of , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation ANGPT1 MAPK9 22508858 2613309 TLR2 mediated enhancement of angiogenic growth factor production in CP individuals was shown to be dependent on mitogen activated protein kinase (MAPK) and NF-?B signaling , as pharmacologic inhibition of either extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 , or NF-?B signaling *resulted* in significantly diminished production of VEGF-A and [Ang-1] . Positive_regulation ANGPT1 MMP2 10807867 692376 [Ang1] *induced* the secretion of plasmin and , which is inhibited by PI 3'-kinase inhibitors . Positive_regulation ANGPT1 MSC 17356562 1791636 [Angiopoietin1/Tie2] and VEGF/Flk1 *induced* by treatment amplifies angiogenesis and vascular stabilization after stroke . Positive_regulation ANGPT1 MSC 18565279 1929496 This study showed that expressed Tie-2 receptor , and [Ang1] *induced* Tie-2 receptor phosphorylation . Positive_regulation ANGPT1 MSH3 8214050 231547 Pretreatment with atenolol decreased the ANG I values by 30 % , whereas *caused* a sixfold increase in plasma [ANG I] levels in the control rats at time 0 . Positive_regulation ANGPT1 MYLIP 22867989 2666127 The *regulates* [angiopoietin-1] signaling and vessel maturation by targeting p85ß . Positive_regulation ANGPT1 MYLIP 22867989 2666131 Our findings suggest that mediated phosphoinositide-3-kinase regulation , not only fine-tunes VEGF signaling , but it strongly *enhances* the activities of [Ang-1] on vessel stabilization and maturation . Positive_regulation ANGPT1 MYLIP 24917145 2946629 [Angiopoietin-1] is *regulated* by and contributes to corneal neovascularization in KLEIP-deficient mice . Positive_regulation ANGPT1 NFKB1 18505784 1945069 [Ang-1] up-regulation is *mediated* by the activation of the transcription factor . Positive_regulation ANGPT1 NR2F2 20133706 2213529 We showed that directly *regulates* the transcription of [Angiopoietin-1] in pericytes to enhance neoangiogenesis . Positive_regulation ANGPT1 NR4A1 22628435 2614766 Both [Ang-1] and VEGF *induce* expression , by > 5- and 30-fold , respectively . Positive_regulation ANGPT1 PDGFB 14755687 1205836 Interestingly , TGF-beta negatively regulated [Ang1] expression *induced* by the stimulation in SMCs . Positive_regulation ANGPT1 PI3 17215522 1709678 [Angiopoietin] chemotactic activities on neutrophils are *regulated* by activation . Positive_regulation ANGPT1 PIK3CA 10807867 692370 [Ang1] induced tyrosine phosphorylation of p125(FAK) , and this phosphorylation was *dependent* on activity . Positive_regulation ANGPT1 PIK3R1 10807867 692371 [Ang1] induced tyrosine phosphorylation of p125(FAK) , and this phosphorylation was *dependent* on activity . Positive_regulation ANGPT1 PLG 10807867 692377 [Ang1] *induced* the secretion of and matrix metalloproteinase-2 (MMP-2) , which is inhibited by PI 3'-kinase inhibitors . Positive_regulation ANGPT1 POLDIP2 12213726 985675 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of [Ang-1] and Ang-2 as well as the *activation* of MAPK , SAPK/JNK , and by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation ANGPT1 PTGS2 21266034 2392676 The results of RT-PCR and western blot showed that down-regulation of might *inhibit* VEGF , Flt-1 , Flk-1/KDR , [angiopoietin-1] , tie-2 , MMP2 and OPN . Positive_regulation ANGPT1 PTH 17039426 1631027 ( 1-34 ) *augments* [angiopoietin-1] expression in human osteoblast-like cells . Positive_regulation ANGPT1 PTK2 10807867 692372 [Ang1] *induced* tyrosine phosphorylation of , and this phosphorylation was dependent on phosphatidylinositol (PI) 3'-kinase activity . Positive_regulation ANGPT1 RASA1 21885850 2496448 [Angiopoietin-1] *requires* IQ domain 1 to activate Rac1 and promote endothelial barrier defense . Positive_regulation ANGPT1 RECK 20407016 2262405 Here , we show that an angiogenic factor [angiopoietin-1] *induces* expression in human umbilical vein endothelial cells ( HUVEC ) , and RECK depletion in these cells results in defective vascular tube formation and cellular senescence . Positive_regulation ANGPT1 RELA 18505784 1945070 [Ang-1] up-regulation is *mediated* by the activation of the transcription factor . Positive_regulation ANGPT1 REN 1818898 177490 Thus , our results indicate that extrarenally synthesized does not *contribute* significantly to circulating levels of [Ang I] and II . Positive_regulation ANGPT1 REN 1930850 169954 When maintained on Stroke-Prone Rodent Diet and saline , plasma activity of untreated SHRSP surviving until 14.5 weeks of age was markedly *increased* ( 29.1 +/- 9.4 ng [Ang I/mL/h] ) compared with either untreated SHRSP ( 9.2 +/- 2.5 ng Ang I/mL/h , P less than .01 ) or Wistar-Kyoto rats ( 3.5 +/- 1.0 ng Ang I/mL/h , P less than .01 ) maintained on standard diet and water . Positive_regulation ANGPT1 REN 2204498 140721 Generation of [Ang I] and Ang II was inhibited in the *presence* of specific inhibitors of and converting enzyme , respectively . Positive_regulation ANGPT1 REN 7635534 317327 Active human at doses of 3 , 10 , and 30 ng/mL perfusate for 15 minutes *increased* [Ang I] release from undetectable levels ( mean +/- SEM ) to 31.9 +/- 3.3 , 147.1 +/- 26.2 , and 206.4 +/- 17.1 fmol/mL , respectively , by 9 minutes . Positive_regulation ANGPT1 REN 7641363 317888 This intermittent partial `` escape '' is explained either by a *mediated* reactive rise in plasma [Ang I] or by non-ACE dependent Ang II generation . Positive_regulation ANGPT1 REN 8498556 220843 However , only small nonsignificant changes in arterial plasma renin activity and AVP concentration occurred [ control : renin = 0.46 +/- 0.8 ng angiotensin I (ANG I) . ml-1 .h-1 , AVP = 0.53 +/- 0.17 pg/ml ; metaboreflex *activation* : = 0.77 +/- 0.33 ng [ANG I] . ml-1 .h-1 , AVP = 1.09 +/- 0.34 pg/ml ] . Positive_regulation ANGPT1 REN 9931122 589017 ( 10 ng/mL for 15 minutes ) *caused* sustained release of [Ang I] ( 153+/-16 fmol/mL ) . Positive_regulation ANGPT1 SHH 17273793 1691769 inversely *regulates* the expression of [angiopoietin-1] and angiopoietin-2 in fibroblasts . Positive_regulation ANGPT1 SHH 17273793 1691773 Using NIH3T3 embryonic fibroblast cells , we demonstrated that *increased* the mRNA levels of [angiopoietin-1 (Ang-1)] , a secreted ligand that regulates endothelial interaction with mural cells ( pericytes and smooth muscle cells ) and promotes blood vessel maturation . Positive_regulation ANGPT1 SHH 17273793 1691774 The addition of cyclopamine , an inhibitor of Shh signaling , to NIH3T3 cells , suppressed the regulation of [Ang-1] and Ang-2 mRNA levels in the *presence* of . Positive_regulation ANGPT1 SHH 20098680 2201895 In vitro co-culture and matrigel plug assays demonstrated that PDAC cell derived *induced* [Ang-1] and IGF-1 production in BMPCs , resulting in their enhanced migration and capillary morphogenesis activity . Positive_regulation ANGPT1 SHH 20112075 2258770 *enhanced* [Ang-1] expression but did not enhance vascular endothelial growth factor in fibroblasts . Positive_regulation ANGPT1 SHH 20112075 2258771 The *upregulation* of [Ang-1] expression by was significantly decreased by fibroblast growth factor-2 (FGF-2) , a potent angiogenic factor . Positive_regulation ANGPT1 SHH 23378030 2775854 The results of silencing Gli-1 , or NR2F2 , exhibited that exogenous could *regulate* the expressions of VEGF , [Ang-1] , and Ang-2 in astrocytes by activating the NR2F2 , but not the Gli-1 . Positive_regulation ANGPT1 SHH 23894369 2821836 Moreover , *increases* zonula occludens-1 (ZO-1) , occludin and [angiopiotetin-1 (Ang-1)] expression in the ischemic penumbra . Positive_regulation ANGPT1 SHH 23894369 2821838 also *increased* ZO-1 , occludin and [Ang-1] expression in BMECs , while cyclopamine and Ang-1 neutralizing antibody inhibited the effects of Shh on the ZO-1 and occludin expression , respectively . Positive_regulation ANGPT1 SHH 23894369 2821842 This study suggests that , under ischemic insults , *triggers* [Ang-1] production predominantly in astrocytes , and the secreted Ang-1 acts on BMECs , thereby upregulating ZO-1 and occludin to repair the tight junction and ameliorate the brain edema and BBB leakage . Positive_regulation ANGPT1 SLC33A1 12586636 1084939 The lisinopril-insensitive response may be related to conversion by unknown enzyme ( s ) and/or to *activation* of receptors by [ANG I] . Positive_regulation ANGPT1 SLC33A1 9231819 445012 Thus , Ang II , but not [Ang I] , from the circulation is accumulated by some tissues , and this is *mediated* by receptors . Positive_regulation ANGPT1 SMC2 16690881 1570030 Prolonged AAV mediated [Ang1] transgene expression also *induced* activation , whereas AAV-Ang2 lacked the SMC activating effects and decreased CAV . Positive_regulation ANGPT1 SMC2 17544375 1751894 EC expressing [Ang-1] in the *presence* of expressing VEGF exhibited high levels of sprouting of the two cell types . Positive_regulation ANGPT1 SMC2 17544375 1751911 Autologous secretion of [Ang-1] by transduced EC resulted in Tie-2 activation and in the *presence* of expressing VEGF resulted in coordinated sprouting in vitro and increase in flow and number of arteries in vivo . Positive_regulation ANGPT1 SMC3 16690881 1570034 Prolonged AAV mediated [Ang1] transgene expression also *induced* activation , whereas AAV-Ang2 lacked the SMC activating effects and decreased CAV . Positive_regulation ANGPT1 SMC3 17544375 1751898 EC expressing [Ang-1] in the *presence* of expressing VEGF exhibited high levels of sprouting of the two cell types . Positive_regulation ANGPT1 SMC3 17544375 1751915 Autologous secretion of [Ang-1] by transduced EC resulted in Tie-2 activation and in the *presence* of expressing VEGF resulted in coordinated sprouting in vitro and increase in flow and number of arteries in vivo . Positive_regulation ANGPT1 SMC4 16690881 1570031 Prolonged AAV mediated [Ang1] transgene expression also *induced* activation , whereas AAV-Ang2 lacked the SMC activating effects and decreased CAV . Positive_regulation ANGPT1 SMC4 17544375 1751895 EC expressing [Ang-1] in the *presence* of expressing VEGF exhibited high levels of sprouting of the two cell types . Positive_regulation ANGPT1 SMC4 17544375 1751912 Autologous secretion of [Ang-1] by transduced EC resulted in Tie-2 activation and in the *presence* of expressing VEGF resulted in coordinated sprouting in vitro and increase in flow and number of arteries in vivo . Positive_regulation ANGPT1 SMC5 16690881 1570032 Prolonged AAV mediated [Ang1] transgene expression also *induced* activation , whereas AAV-Ang2 lacked the SMC activating effects and decreased CAV . Positive_regulation ANGPT1 SMC5 17544375 1751896 EC expressing [Ang-1] in the *presence* of expressing VEGF exhibited high levels of sprouting of the two cell types . Positive_regulation ANGPT1 SMC5 17544375 1751913 Autologous secretion of [Ang-1] by transduced EC resulted in Tie-2 activation and in the *presence* of expressing VEGF resulted in coordinated sprouting in vitro and increase in flow and number of arteries in vivo . Positive_regulation ANGPT1 SMC6 16690881 1570033 Prolonged AAV mediated [Ang1] transgene expression also *induced* activation , whereas AAV-Ang2 lacked the SMC activating effects and decreased CAV . Positive_regulation ANGPT1 SMC6 17544375 1751897 EC expressing [Ang-1] in the *presence* of expressing VEGF exhibited high levels of sprouting of the two cell types . Positive_regulation ANGPT1 SMC6 17544375 1751914 Autologous secretion of [Ang-1] by transduced EC resulted in Tie-2 activation and in the *presence* of expressing VEGF resulted in coordinated sprouting in vitro and increase in flow and number of arteries in vivo . Positive_regulation ANGPT1 STS 23486192 2787637 We examined whether produced angiopoietin-1 (Ang1) and whether [Ang1] functionally *mediated* ASC induced suppression of neointimal formation . Positive_regulation ANGPT1 TEK 9723709 529260 Two recently identified ligands , termed Angiopoietin-1 and -2 , bound to TEK with similar affinities , and [Angiopoietin-1] effectively *induced* TEK phosphorylation in hematopoietic cells . Positive_regulation ANGPT1 TIE1 10527766 654276 Although recombinant [Ang-1] , which *induces* phosphorylation , has no effect on the proliferation of endothelial cells , treatment of confluent adult bovine aortic endothelial cells ( ABAE ) cells grown on collagen gels with Ang-1 ( 100 ng/ml ) causes the cells to migrate into the collagen gel and form capillary-like tubules . Positive_regulation ANGPT1 TIE1 11348459 814393 [Angiopoietin 1] *induces* signaling as a receptor activator and maintains blood vessel formation , whereas angiopoietin 2 destabilizes vessels by blocking Tie2 signaling as an antagonist of angiopoietin 1 and acts with vascular endothelial growth factor to initiate angiogenesis . Positive_regulation ANGPT1 TIE1 12427764 1036919 Collectively , the data show that the first 104 amino acids of the receptor are *essential* but not sufficient for [angiopoietin] binding . Positive_regulation ANGPT1 TIE1 15094228 1238241 [Angiopoietin-1] and Angiopoietin-2 were *detected* in hepatoma cells , hepatic stellate cells , and smooth muscle cells , whereas was detected in endothelial cells , hepatic stellate cells and smooth muscle cells . Positive_regulation ANGPT1 TIE1 16895971 1601122 *Activation* of by [angiopoietin-1] and angiopoietin-2 results in their release and receptor internalization . Positive_regulation ANGPT1 TIE1 17728252 1807885 Activation of Tie1 ectodomain cleavage increases cartilage oligomeric protein [angiopoietin 1] *activation* of . Positive_regulation ANGPT1 TIE1 18425119 1907993 In contrast , in contacting cells [Ang1] *induced* Tie2 translocation to cell-cell contacts and the formation of homotypic trans associated complexes that included the vascular endothelial phosphotyrosine phosphatase , leading to inhibition of paracellular permeability . Positive_regulation ANGPT1 TIE1 18565279 1929495 This study showed that MSC expressed receptor , and [Ang1] *induced* Tie-2 receptor phosphorylation . Positive_regulation ANGPT1 TIE1 19838115 2184160 Early experiments showed that Ang1 stabilizes newly formed vessels and reduces vascular permeability , with Ang2 blocking [Ang1] *activation* of the receptor . Positive_regulation ANGPT1 TIE1 19922791 2184708 Previous work has shown that [Ang1] binding and *activation* of are inhibited by Tie1 , a related receptor that complexes with Tie2 in cells . Positive_regulation ANGPT1 TIE1 19922791 2184720 This differential regulation of angiopoietin binding allows control of Tie2 activation response to Ang1 without affecting Ang2 agonist activity and maintains the ability of Ang2 to antagonize even the enhanced [Ang1] *activation* of that occurs on loss of Tie1 ectodomain . Positive_regulation ANGPT1 TIE1 20227369 2223732 To address the *role* of in [angiopoietin] mediated Tie2 signaling and determine the basis for the behavior of the individual angiopoietins , we used an in vivo FRET based proximity assay to monitor Tie1 and -2 localization and association . Positive_regulation ANGPT1 TIE1 20633009 2334887 In contrast , vascular expression of [Ang-1] was decreased slightly in early scars , vascular Ang-2 remained constant and vascular expression *increased* , although there were no correlations with scar age or MVD . Positive_regulation ANGPT1 TIE1 21273558 2403168 Primary monocytes regulate endothelial cell survival through secretion of [angiopoietin-1] and *activation* of endothelial . Positive_regulation ANGPT1 TIE1 21273558 2403170 The direct interaction of primary monocytes with subconfluent endothelial cells resulted in transient secretion of [angiopoietin-1] from monocytes and the *activation* of endothelial . Positive_regulation ANGPT1 TIE1 22103492 2509484 Ectodomain cleavage of relieves inhibition of Tie2 and *enhances* [Ang1] signalling . Positive_regulation ANGPT1 TIE1 22357955 2606195 We show here that Ang2 , but not [Ang1] , *induces* translocation to the specific cell-matrix contact sites located at the distal end of focal adhesions . Positive_regulation ANGPT1 TIE1 8980223 403725 Although [Angiopoietin-1] binds and *induces* the tyrosine phosphorylation of , it does not directly promote the growth of cultured endothelial cells . Positive_regulation ANGPT1 TNF 13130465 1140034 Primary cultured endothelial cells and synoviocytes were used to study *induced* Tie2 and [Ang1] expression . Positive_regulation ANGPT1 TNF 14715662 1219535 [Ang-1] expression is up-regulated in *response* to . Positive_regulation ANGPT1 TNF 17466926 1731956 Although stimulation with or IFN-gamma *had* little or no effect on [Ang-1] secretion , costimulation with IFN-gamma plus TNF-alpha dose- and time-dependently diminished secretion of Ang-1 from hOBs . Positive_regulation ANGPT1 TNF 18823985 1981550 In primary cultures , activated HSCs express and secrete [angiopoietin 1] more abundantly than quiescent HSCs , and the inflammatory cytokine *stimulates* its expression in an nuclear factor-kappaB dependent manner . Positive_regulation ANGPT1 VEGFA 11381069 820582 [Angiopoietin-1] *upregulation* by in human retinal pigment epithelial cells . Positive_regulation ANGPT1 VEGFA 11381069 820583 To determine whether ( VEGF ) *regulates* [angiopoietin (Ang)-1] and -2 expression in retinal pigment epithelial (RPE) cells . Positive_regulation ANGPT1 VEGFA 11381069 820588 The colocalization of Ang1 and Ang2 with VEGF in CNVM stromal cells and the *upregulation* of [Ang1] expression by in cultured RPE cells suggest that VEGF may selectively modulate Ang expression during CNV . Positive_regulation ANGPT1 VEGFA 12717391 1083862 In conclusion , an increased expression of [Ang-2/1] in the *presence* of may play a critical role in promoting tumor angiogenesis and progression in human HCC . Positive_regulation ANGPT1 VEGFA 17356562 1791639 In this study , we tested whether MSC treatment of stroke *increases* [Ang1/Tie2] expression , and whether Ang1/Tie2 with VEGF/ receptor 2 ( VEGFR2 ) ( Flk1 ) , in combination , induced by MSCs enhances angiogenesis and vascular integrity . Positive_regulation ANGPT1 VEGFA 17502485 1739952 [Angiopoietin 1 (Ang1)] prevented regression of the TGFbeta1 induced CLS , an effect that was blocked by angiopoietin 2 (Ang2) , but *required* the continuous presence of . Positive_regulation ANGPT1 VEGFA 17901375 1824158 These findings demonstrate that *regulates* [angiopoietin-Tie2] signaling by inducing proteolytic cleavage and shedding of Tie2 via a novel PI3K/Akt dependent pathway . Positive_regulation ANGPT1 VEGFA 19075960 1841084 [Ang-1] has been shown to induce the migration and sprouting of endothelial cells , and coexpression of Ang-1 and *enhanced* angiogenesis . Positive_regulation ANGPT1 VEGFA 22235284 2537949 The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by and TNFa and *regulates* [angiopoietin] signalling . Positive_regulation ANGPT1 VEGFA 9774272 539633 Targeted gene inactivation studies in mice have shown that is necessary for the early stages of vascular development and that [angiopoietin-1] is *required* for the later stages of vascular remodeling . Positive_regulation ANGPT2 ANGPT1 11230987 789433 ( 200 ng/ml ) *induced* Tie2 phosphorylation , while [Ang2] ( 200 ng/ml ) did not produce Tie2 phosphorylation . Positive_regulation ANGPT2 ANGPT1 11786504 901319 Arterial , resulting in high interstitial [Ang II] *levels* via its local conversion by ACE , may be of greater physiological importance than arterial Ang II . Positive_regulation ANGPT2 ANGPT1 12359982 994888 Circulating ( pro ) renin , angiotensinogen , and ANG II enter the interstitium via diffusion , and interstitial [ANG II] generation is *mediated* , at least in part , by basolaterally located endothelial ACE . Positive_regulation ANGPT2 ANGPT1 12372776 996494 In LS rats , in both plasma and renal cortex , the increase in RA was associated with an increase in and ANG II levels compared with NS rats , but intrarenal [ANG II] levels *increased* more than ANG I levels . Positive_regulation ANGPT2 ANGPT1 1510141 196556 These results indicate that production of at tissue sites contributes to its circulating level and that some circulating [ANG II] may not be *derived* from circulating ANG I . Positive_regulation ANGPT2 ANGPT1 16107612 1448412 These phenotypes depend strongly on p110gamma rather than on p85alpha and were associated with decreased expression of , VCAM-1 , connexin 40 , and ephrinB2 but *increased* expression of [Ang-2] , VEGF-A , VEGFR1 , and VEGFR2 . Positive_regulation ANGPT2 ANGPT1 17215522 1709685 Angiopoietins induce a rapid and transient Akt phosphorylation , and pretreatment of neutrophils with PI-3K inhibitors , wortmannin ( 100 nM ) and LY294002 ( 500 nM ) , reduced *mediated* neutrophil migration by 100 % and 78 % and [Ang2] chemotactic activity by 100 % and 71 % , respectively . Positive_regulation ANGPT2 ANGPT1 18310225 1897439 We conclude that in vivo endotoxemia triggers functional inhibition of the Ang-1/Tie-2 receptor pathway by reducing and Tie-2 expression and *inducing* [Ang-2] levels and that this response may contribute to enhanced vascular leakage in sepsis . Positive_regulation ANGPT2 ANGPT1 1951760 172305 Thus 1 ) circulating ANG I and II are potent constrictors of blood vessels of the choroid plexus , 2 ) the constrictor effect of on the blood vessels of the choroid plexus appears *mediated* primarily by generation of [ANG II] , and 3 ) intracerebroventricular ANG I produces large reductions in the blood flow to the choroid plexus , which suggests that there is an effective central system that converts ANG I to ANG II . Positive_regulation ANGPT2 ANGPT1 21943108 2554960 Its ability to inhibit [Ang-2] but not *induced* endothelial cell migration , and to down-regulate Tie2 levels in tumour microvessels , suggests that A11 targets the Ang-Tie2 pathway . Positive_regulation ANGPT2 ANGPT1 24704536 2938789 Thus , [Ang2] *inhibition* , independent of inhibition , improves the activity of sunitinib and plasma Ang2 increases in the setting of progression on sunitinib possibly contributing to resistance . Positive_regulation ANGPT2 ANGPT1 24799613 2944658 P < 0.05 ) and prevalence of subarachnoid hemorrhage ( from 75 % to 48 % ; P < 0.05 ) . In cerebral arteries , expression of the inflammatory markers , Nox2 and catalase increased similarly in [elastase+Ang II] or elastase+Ang II+Ang 1-7 groups. *increased* the expression of cyclooxygenase-2 and decreased the expression of matrix metalloproteinase-9 induced by elastase+Ang II ( P < 0.05 ) . In Mas receptor-deficient mice , systolic blood pressure , mortality , and prevalence of subarachnoid hemorrhage were similar ( P > 0.05 ) in groups treated with elastase+Ang II or elastase+Ang II+Ang 1-7 . Positive_regulation ANGPT2 ANGPT1 2539750 109962 Comparison of the ANG I and ANG II levels in in vitro incubated perfusates and circulated perfusates shows that in plasma injected perfusates the level of immunoreactive [ANG II] is *dependent* on both the production of and its conversion to ANG II by renal and perfusate converting-enzyme activity , and on ANG I and ANG II degradation by the kidney and the perfusate . Positive_regulation ANGPT2 ANGPT1 3241230 103734 Selectivity for the carboxy-terminus of angiotensin II (Ang II) and the high affinity of antibodies are prerequisites for clinical assays that evaluate [Ang II] in the *presence* of . Positive_regulation ANGPT2 ANGPT1 8023987 263277 These results demonstrate that , II , and III have similar pulmonary pressor activity and that responses are *mediated* by [ANG II] type 1 receptors . Positive_regulation ANGPT2 CCND1 10843991 721994 [Ang II] also *induced* protein expression in a phosphatidylinositol 3-kinase and mitogen activated protein kinase/extracellular signal regulated kinase ( MAPK/ERK ) -dependent manner . Positive_regulation ANGPT2 CCND1 11502738 868190 We recently reported that in these cells , [Ang II] *induced* promoter activation and protein expression in a phosphatidylinositol 3-kinase (PI3K)- , SHP-2- , and mitogen activated protein kinase/extracellular signal regulated kinase ( MAPK/ERK ) -dependent manner ( Guillemot , L. , Levy , A. , Zhao , Z. J. , Béréziat , G. , and Rothhut , B. ( 2000 ) J. Biol. Chem. 275 , 26349-26358 ) . Positive_regulation ANGPT2 CD14 19920349 2171816 Further analysis revealed that [Ang II] *induced* macrophage accumulation selectively in aortic dissections and not in aortas from Il6-/- mice . Positive_regulation ANGPT2 CTGF 12819040 1103869 In transgenic rats harboring human renin and angiotensinogen genes , [Ang II] *induced* an age dependent increase in myocardial expression , which was 3.5-fold greater compared to normotensive Sprague Dawley ( SD ) rats . Positive_regulation ANGPT2 CTGF 12952842 1143275 In growth arrested vascular smooth muscle cells , [Ang II] *induced* mRNA expression after 1 hour , remained elevated up to 24 hours , and increased CTGF protein production , which was increased up to 72 hours . Positive_regulation ANGPT2 CTGF 19667256 2138714 Additional studies revealed that , in addition to a late ( 24-hour ) TGF-beta dependent Smad2/3 activation , [Ang II] also *induced* a rapid activation of Smad2/3 at 15 minutes and expression of and collagen I in tubular epithelial cells lacking the TGF-beta gene , which was blocked by the addition of an Ang II type 1 receptor antagonist ( losartan ) and inhibitors to extracellular signal regulated kinase 1/2 ( PD98059 ) and p38 ( SB203580 ) but not by inhibitors to Ang II type 2 receptor ( PD123319 ) or c-Jun N-terminal kinase ( SP600125 ) , demonstrating a TGF-beta independent , Ang II type 1 receptor mediated extracellular signal regulated kinase/p38 mitogen activated protein kinase cross-talk pathway in Ang II-mediated CTGF and collagen I expression . Positive_regulation ANGPT2 CTGF 19667256 2138723 In conclusion , [Ang II] *induces* tubular expression and renal fibrosis via the TGF-beta dependent and -independent Smad3 signaling pathways , suggesting that targeting Smad3 may have therapeutic potential for hypertensive nephropathy . Positive_regulation ANGPT2 CTGF 21719784 2451687 [Ang II] can directly *induce* expression of renal and mediate epithelial-mesenchymal transition . Positive_regulation ANGPT2 CTGF 22964022 2678755 In this paper , we show that in myoblasts , [Ang-II] *induced* the increase of transforming growth factor beta 1 ( TGF-ß1 ) and expression through its AT-1 receptor . Positive_regulation ANGPT2 EPHB2 10406835 629634 Thus , we show that , through AP-1 activation , is *involved* in [Ang II-induced] TGF-beta(1) mRNA expression in VSMCs and suggest that ERK may participate in vascular remodeling of hypertension . Positive_regulation ANGPT2 EPHB2 10788453 688712 In the present study , we explored the effects of angiotensin II (Ang II) type-1 receptor ( AT(1) ) internalization on [Ang II-induced] *activation* of using the receptor internalization blocker concanavalin A ( ConA ) and the carboxyl terminus truncated receptor mutants with impaired internalization . Positive_regulation ANGPT2 EPHB2 10891386 710826 On the other hand , the other thiazolidinediones pioglitazone ( PIO ) and rosiglitazone ( ROSI ) had little effect on [Ang II-induced] *activation* of or AP-1 , suggesting the inhibitory effects of TRO on VSMC activation by Ang II be independent of the peroxisome proliferator activated receptor-gamma ( PPARgamma ) for which thiazolidinediones are ligands . Positive_regulation ANGPT2 EPHB2 10891597 711261 While [ANG II] *induced* an initial activation of in quiescent cells , the NGF mediated plateau of ERK-stimulation was lowered by costimulation with ANG II . Positive_regulation ANGPT2 EPHB2 10916078 716708 In addition , the same nanomolar concentrations of AG 1478 that were effective in EGF signaling blocked the [Ang II-induced] *activation* of and PI3 kinase in a dose dependent manner . Positive_regulation ANGPT2 EPHB2 10988260 732592 In addition , [Ang II] *induced* a rapid ( 5 minutes ) increase of the activity that was accompanied by increased expression ( 3-fold ) of the c-fos proto-oncogene . Positive_regulation ANGPT2 EPHB2 11463768 839304 Although inhibition of extracellular signal regulated protein kinase ( ERK ) by PD 098,059 also inhibited Ang II-induced MCP-1 expression , Y-27632 did not affect [Ang II-induced] *activation* of . Positive_regulation ANGPT2 EPHB2 12620889 1091871 To investigate the effects of receptor mediated PKC activation on mitogenesis , we demonstrated that [ANG II] *induced* activation , a response completely blocked by pretreatment with mitogen/extracellular signal regulated kinase inhibitors or specific PKC inhibitors . Positive_regulation ANGPT2 EPHB2 14605021 1176299 PD98059 or introduction of kinase-inactive MEK1/MKK1 , but not SB202190 or kinase-inactive p38 MAP kinase , inhibited Ang II-induced Mnk1 activation and eIF4E phosphorylation , suggesting that , but not p38 MAP kinase , is *required* for [Ang II-induced] Mnk1-eIF4E activation . Positive_regulation ANGPT2 EPHB2 14730203 1211800 An inhibitor , U0126 , *inhibited* [Ang II-induced] ET-1 expression completely . Positive_regulation ANGPT2 EPHB2 15322702 1303797 [Ang II] induced LV remodeling and fibrosis are *dependent* on both and Smad2 activation . Positive_regulation ANGPT2 EPHB2 15894894 1407876 An immediate activation of both and p38 MAP-kinase and of cPLA2 was *induced* by [Ang II] in human neutrophils . Positive_regulation ANGPT2 EPHB2 15894894 1407889 These results suggest that either or p38 MAP-kinase are involved in the activation of both cPLA2 and NADPH oxidase , and that cPLA2 is *required* for activation of the NADPH oxidase by [Ang II] in human neutrophils . Positive_regulation ANGPT2 EPHB2 16461377 1567549 TG and [ANG II] *induced* phosphorylation of , which was sensitive to 2-APB and was selectively required for CRE binding protein phosphorylation . Positive_regulation ANGPT2 EPHB2 16554661 1574677 These data indicate that activation is *induced* by [ANG2] in podocytes by mechanisms involving ANG2 dependent release of HB-EGF which , in turn , may act in an autocrine and paracrine fashion to stimulate ERK activity . Positive_regulation ANGPT2 EPHB2 17308086 1699403 Consistent with the important roles of AKT and mitogen activated protein kinase in the HER2 signaling pathway , AKT and mitogen activated protein kinase (MAPK) kinase activity is *necessary* for [Ang-2] up-regulation by HER2 . Positive_regulation ANGPT2 EPHB2 25088996 2954080 In conclusion , Ang II enhances ET-1 induced vasoconstriction by upregulating ETAR expression and ET-1/ETAR binding , which may be because of the [AngII/Ang II] receptor pathways and the *activation* of PKC or . Positive_regulation ANGPT2 EPHB2 9774361 539726 These findings demonstrate that in cardiac fibroblasts , [Ang II] *induced* activation is dominantly regulated by Gq-coupled Ca2+/calmodulin signaling and that Pyk2 plays an important role in the signal transmission for efficient activation of the Ang II induced Ras/ERK pathway . Positive_regulation ANGPT2 EPHB2 9886938 584889 [ANG II-induced] *activations* of Fyn , Raf-1 , and were augmented in cells pretreated with BAPTA-AM , but ANG II-induced expression of the dual-specificity phosphatase mitogen activated protein kinase phosphatase-1 was blocked by BAPTA-AM pretreatment . Positive_regulation ANGPT2 EPHB2 9933031 589203 On the other hand , an obligatory tyrosine phosphorylation step for activation of ERK was indicated by the use of protein tyrosine kinase inhibitors , which profoundly inhibited the *activation* of by EGF , [Ang II] , and PMA . Positive_regulation ANGPT2 FOXO1 16100571 1448309 Whereas [angiopoietin 2 (Ang2)] was exclusively *regulated* by , eNOS , which is essential for postnatal neovascularization , was regulated by Foxo1 and Foxo3a . Positive_regulation ANGPT2 FOXO1 17030814 1634457 Here , we demonstrate that [Ang-2] expression is rapidly *induced* in endothelial cells by the transcription factor after inhibition of the phosphatidylinositol 3-kinase/Akt pathway . Positive_regulation ANGPT2 FOXO1 18006475 1851636 As *regulates* the expression of [angiopoietin-2 (Ang-2)] , we determined the role of shear stress and the AMPK in this phenomenon . Positive_regulation ANGPT2 GPR115 17483315 1738861 Kaposi 's sarcoma associated herpesvirus encoded interleukin-6 and *regulate* [angiopoietin-2] expression in lymphatic endothelial cells . Positive_regulation ANGPT2 GPR115 8088922 271602 These findings suggest that [Ang II] *induces* the phosphorylation of its own through both serine and tyrosine kinases and raise the possibility that phosphorylation of the AT1AR is an important regulator of receptor function . Positive_regulation ANGPT2 GPR115 9421435 481107 In view of this unique property and the presence of putative nuclear localization signal ( NLS ) consensus sequence in the AT1 receptor , this study was conducted to investigate the hypothesis that [Ang II] would *induce* nuclear sequestration of this and that the sequestration may have implications on Ang II-induced expression of NET and TH genes . Positive_regulation ANGPT2 GPR132 17483315 1738850 Kaposi 's sarcoma associated herpesvirus encoded interleukin-6 and *regulate* [angiopoietin-2] expression in lymphatic endothelial cells . Positive_regulation ANGPT2 GPR132 8088922 271591 These findings suggest that [Ang II] *induces* the phosphorylation of its own through both serine and tyrosine kinases and raise the possibility that phosphorylation of the AT1AR is an important regulator of receptor function . Positive_regulation ANGPT2 GPR132 9421435 481096 In view of this unique property and the presence of putative nuclear localization signal ( NLS ) consensus sequence in the AT1 receptor , this study was conducted to investigate the hypothesis that [Ang II] would *induce* nuclear sequestration of this and that the sequestration may have implications on Ang II-induced expression of NET and TH genes . Positive_regulation ANGPT2 GPR87 17483315 1738930 Kaposi 's sarcoma associated herpesvirus encoded interleukin-6 and *regulate* [angiopoietin-2] expression in lymphatic endothelial cells . Positive_regulation ANGPT2 GPR87 8088922 271671 These findings suggest that [Ang II] *induces* the phosphorylation of its own through both serine and tyrosine kinases and raise the possibility that phosphorylation of the AT1AR is an important regulator of receptor function . Positive_regulation ANGPT2 GPR87 9421435 481176 In view of this unique property and the presence of putative nuclear localization signal ( NLS ) consensus sequence in the AT1 receptor , this study was conducted to investigate the hypothesis that [Ang II] would *induce* nuclear sequestration of this and that the sequestration may have implications on Ang II-induced expression of NET and TH genes . Positive_regulation ANGPT2 HBEGF 11737589 885868 We studied the *roles* of and endothelial growth factor (EGF) receptor ( EGFR ) in [Ang II-induced] FN expression using mesangial cells . Positive_regulation ANGPT2 HBEGF 11737589 885876 [Ang II-mediated] FN expression was *regulated* by autocrine effects of and TGF-beta , suggesting a novel paradigm for cross-talk between Ang II and growth factor receptor signaling pathways . Positive_regulation ANGPT2 HBEGF 16267402 1479105 Furthermore Ang II-stimulated proliferation and migration of smooth muscle cells were significantly blunted by inhibiting MMPs and EGFR and applying HB-EGF neutralization antibody , indicating that MMPs , and EGFR activation is *necessary* for [Ang-II] stimulated migration and proliferation of smooth muscle cells . Positive_regulation ANGPT2 IL1B 17989112 1850950 For this reason , in cultured mesangial cells ( MC ) , we investigated whether could *regulate* [ANG II-mediated] collagen accumulation and the mechanisms underlying this process . Positive_regulation ANGPT2 ITGB2 19728062 2175868 Additionally , blockade significantly *inhibited* the [Ang-2/PDGF-BB] based increase in matrix metalloproteinase-9 (MMP-9) and membrane type-1-MMP (MT1-MMP) . Positive_regulation ANGPT2 MAP2K6 14600156 1187517 Similar maneuvers significantly attenuated 5-HT- or [Ang II-mediated] *activation* of and Ras but not transphosphorylation of the epidermal growth factor (EGF) receptor . Positive_regulation ANGPT2 MAP2K6 16513650 1555025 The use of pharmacological inhibitors that inhibit the *activation* of by [Ang II] revealed that phosphorylation of p65 on serine 536 did not require the MEK-ERK-RSK signaling pathway . Positive_regulation ANGPT2 MAP2K6 18256306 1924669 Of importance , [Ang II] significantly *induced* the expression of receptor activator of NF-kappaB ligand ( RANKL ) in osteoblasts , leading to the activation of osteoclasts , whereas these effects were completely blocked by an Ang II type 1 receptor blockade ( olmesartan ) and inhibitors . Positive_regulation ANGPT2 MMP28 21460197 2433222 Inhibition of activation ( with GM-6001 ) or ROS production ( with apocynin or tempol ) *prevented* the NE + [ANG II-induced] inward remodeling . Positive_regulation ANGPT2 MMP7 21460197 2433237 Inhibition of activation ( with GM-6001 ) or ROS production ( with apocynin or tempol ) *prevented* the NE + [ANG II-induced] inward remodeling . Positive_regulation ANGPT2 MYH16 12016267 942326 Furthermore , [Ang II] *induced* the promoter activity of the nonmuscle-type B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was inhibited by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or mitogen activated protein kinase kinase 6 . Positive_regulation ANGPT2 MYH3 12016267 942333 Furthermore , [Ang II] *induced* the promoter activity of the nonmuscle-type B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was inhibited by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or mitogen activated protein kinase kinase 6 . Positive_regulation ANGPT2 RGS2 16627589 1583057 In conclusion , expression is *induced* by [Ang II] to terminate the intracellular signaling cascade generated by Ang II . Positive_regulation ANGPT2 RGS2 18398336 1893705 Silencing in BS/GS patients *increased* [Ang II-induced] Cai2+ release and ERK 1/2 phosphorylation in silenced cells compared with not silenced cells [ 59.3 +/- 10.8 ( peak-basal ) vs. 40.5 +/- 14.1 nmol/l , P = 0.017 and 0.84 +/- 0.06 vs. 0.64 +/- 0.08 nmol/l , P < 0.03 , respectively ] , whereas they were not different compared with controls ( 60.1 +/- 4.3 and 0.91 +/- 0.03 nmol/l ) . Positive_regulation ANGPT2 RGS2 22057271 2516939 Forskolin stimulated RGS2 mRNA up-regulation is inhibited by CREB sequestration or specific disruption of the promoter interaction , and [Ang II-induced] CREB phosphorylation and nuclear localization are *blocked* by iPLA(2)ß pharmacologic inhibition or genetic ablation . Positive_regulation ANGPT2 TNF 11838839 911527 In contrast , and TGF-beta had no effect on Ang-2 expression in RSF , but *augmented* expression of [Ang-2] in normal synovial fibroblasts . Positive_regulation ANGPT2 TNF 12414515 1011009 [Ang II] *induces* dendritic migration directly , whereas in vivo is involved in dendritic cell infiltration and maturation . Positive_regulation ANGPT2 TNF 12512690 1027681 This switching mechanism ( CYP > COX-2 ) has been shown to be dependent on *activation* of by [ANG II] . Positive_regulation ANGPT2 TNF 12801985 1140889 The results of the present study provide , to our knowledge , the first direct evidence that *stimulates* PG , ET-1 , and [Ang II] secretion and that up-regulation of the TNFalpha system occurs in the cow oviduct during the periovulatory period . Positive_regulation ANGPT2 TNF 15780956 1385425 In vitro assessment of cultured fracture callus cells in comparison to primary articular chondrocytes showed that treatment specifically *induced* the expression of MMP9 , MMP14 , VEGI , and [Angiopoietin 2] . Positive_regulation ANGPT2 TNF 18441197 1921020 [ANG II-] and induced *activation* of NF-kappaB- and p38 dependent pathways was partially inhibited by pharmacological inhibitors of ROS production . Positive_regulation ANGPT2 TNF 21235392 2402679 [Ang II] not only *induced* the production of , IL-1ß , IL-6 , and IL-10 but also increased the release of ROS . Positive_regulation ANGPT2 TNF 23065888 2689966 *up-regulated* the gene expression of VEGF , [Angiopoietin-2] , and Tie2 ( p < 0.05 ) . Positive_regulation ANGPT2 TNF 23337087 2747266 In this study , we demonstrate that in vitro , using a human monocyte-to-fibroblast differentiation model , [Ang-II] *required* the presence of to induce fibroblast maturation from monocytes . Positive_regulation ANGPTL2 TNF 21501655 2439101 Finally , TNF-a inhibited Foxo1 phosphorylation and enhanced its transcriptional activity , through which *increased* the expression of [Angptl2] in adipocytes . Positive_regulation ANGPTL4 EPHB2 20025870 2200259 Our observations suggest that the induction of [ANGPTL4] by PMA in HASM *involves* the activation of PKC , , and JNK pathways . Positive_regulation ANGPTL4 EPHB2 23617883 2778781 U0126 , an signal inhibitor dramatically *suppressed* [Angptl4] expression . Positive_regulation ANGPTL4 HBEGF 23443317 2781130 We show that *regulates* the expression of VEGFA or [ANGPTL4] via transcriptional regulation of hypoxia-inducible factor-1a and NF-?B . Positive_regulation ANGPTL4 TNF 18081944 1911043 Insulin , leptin , dexamethasone , noradrenaline , and several IL ( IL-1beta , IL-6 , IL-10 , IL-18 ) *had* little effect on [Angptl4/FIAF] mRNA levels in 3T3-L1 adipocytes . Positive_regulation ANK3 TMEM100 12507143 1027104 Painful neuromas : a potential *role* for a structural , [ankyrin G] . Positive_regulation ANK3 TMEM156 12507143 1027122 Painful neuromas : a potential *role* for a structural , [ankyrin G] . Positive_regulation ANK3 TMEM211 12507143 1027202 Painful neuromas : a potential *role* for a structural , [ankyrin G] . Positive_regulation ANK3 TMEM213 12507143 1027139 Painful neuromas : a potential *role* for a structural , [ankyrin G] . Positive_regulation ANKRD1 AKT1 22085644 2540847 Treatment of reHASMCs with Akt , IKKa , I?Ba , or NF-?B inhibitor inhibits the loss of desmin induced Ankrd1 up-regulation , suggesting *mediated* [Ankrd1] regulation . Positive_regulation ANKRD1 AKT2 22085644 2540848 Treatment of reHASMCs with Akt , IKKa , I?Ba , or NF-?B inhibitor inhibits the loss of desmin induced Ankrd1 up-regulation , suggesting *mediated* [Ankrd1] regulation . Positive_regulation ANKRD1 AKT3 22085644 2540849 Treatment of reHASMCs with Akt , IKKa , I?Ba , or NF-?B inhibitor inhibits the loss of desmin induced Ankrd1 up-regulation , suggesting *mediated* [Ankrd1] regulation . Positive_regulation ANKRD1 DES 22085644 2540846 Treatment of reHASMCs with Akt , IKKa , I?Ba , or NF-?B inhibitor inhibits the loss of *induced* [Ankrd1] up-regulation , suggesting Akt/NF-?B mediated Ankrd1 regulation . Positive_regulation ANKRD1 ZNF804A 23434502 2765555 Furthermore , we confirmed that the expression of [ANKRD1] , PIK3AP1 , INHBE and DDIT3 at the protein level was significantly *increased* by . Positive_regulation ANO1 CA2 23462688 2749886 This means that *dependent* activation of KCa3.1 and [TMEM16A] protects the cells against early hemolysis . Positive_regulation ANO1 CA2 24692353 2931504 [TMEM16A] is directly *regulated* by cytosolic as well as indirectly by its interaction with calmodulin . Positive_regulation ANO1 CALM3 24420770 2907227 Here we show that is not *necessary* for activation of [Ano1] by Ca ( 2+ ) for the following reasons . Positive_regulation ANO1 CALM3 24692353 2931505 [TMEM16A] is directly *regulated* by cytosolic Ca2+ as well as indirectly by its interaction with . Positive_regulation ANO1 EGF 22351639 2586844 chronically *upregulates* Ca ( 2+ ) -dependent Cl ( - ) conductance and [TMEM16A] expression in intestinal epithelial cells . Positive_regulation ANO1 IL4 22988141 2701971 Our results indicate that TMEM16A protein is responsible for CaCC activity in airway epithelial cells , particularly in cells treated with IL-4 , and that [TMEM16A] *upregulation* by appears as an early event of goblet cell differentiation . Positive_regulation ANO1 MAPK1 22564524 2619144 [TMEM16A] *induces* and contributes directly to tumorigenesis and cancer progression . Positive_regulation ANO1 MAPK10 22564524 2619145 [TMEM16A] *induces* and contributes directly to tumorigenesis and cancer progression . Positive_regulation ANO1 MAPK11 22564524 2619146 [TMEM16A] *induces* and contributes directly to tumorigenesis and cancer progression . Positive_regulation ANO1 MAPK12 22564524 2619147 [TMEM16A] *induces* and contributes directly to tumorigenesis and cancer progression . Positive_regulation ANO1 MAPK13 22564524 2619148 [TMEM16A] *induces* and contributes directly to tumorigenesis and cancer progression . Positive_regulation ANO1 MAPK14 22564524 2619149 [TMEM16A] *induces* and contributes directly to tumorigenesis and cancer progression . Positive_regulation ANO1 MAPK15 22564524 2619143 [TMEM16A] *induces* and contributes directly to tumorigenesis and cancer progression . Positive_regulation ANO1 MAPK3 22564524 2619150 [TMEM16A] *induces* and contributes directly to tumorigenesis and cancer progression . Positive_regulation ANO1 MAPK4 22564524 2619151 [TMEM16A] *induces* and contributes directly to tumorigenesis and cancer progression . Positive_regulation ANO1 MAPK6 22564524 2619152 [TMEM16A] *induces* and contributes directly to tumorigenesis and cancer progression . Positive_regulation ANO1 MAPK7 22564524 2619153 [TMEM16A] *induces* and contributes directly to tumorigenesis and cancer progression . Positive_regulation ANO1 MAPK8 22564524 2619154 [TMEM16A] *induces* and contributes directly to tumorigenesis and cancer progression . Positive_regulation ANO1 MAPK9 22564524 2619155 [TMEM16A] *induces* and contributes directly to tumorigenesis and cancer progression . Positive_regulation ANO1 TRPV4 24509911 2933224 Cell volume changes were induced by ANO1 mediated chloride currents in parallel with membrane potential changes , and the cell volume was significantly decreased at negative membrane potentials by *induced* [ANO1] activation . Positive_regulation ANPEP IL1B 11089884 580916 Although significantly *stimulated* [APN] mRNA expression in both cell lines , it influenced the enzyme activity only in MG63 . Positive_regulation ANPEP ITGB2 9683105 521407 The expression of [amino peptidase N] ( CD13 ) , C3bi receptor ( CD11b ) , and the neutrophil beta2 integrin unit ( CD18 ) did not change during the administration of G-CSF , but that of both CD13 and *increased* 3 days after the last dose . Positive_regulation ANPEP STK39 12406907 1054830 Inhibition of these pathways and extracellular signal regulated ( ERK-2 ) and PI-3K by expression of dominant negative proteins or chemical inhibitors *prevented* induction of [CD13/APN] transcription in response to basic fibroblast growth factor (bFGF) . Positive_regulation ANPEP TNF 11089884 580917 and TGF-beta , however , *had* an effect neither on mRNA expression nor on the enzyme activity of [APN] in both cell lines . Positive_regulation ANPEP TNF 17382365 1748428 , produced by feline infectious peritonitis virus ( FIPV ) -infected macrophages , *upregulates* expression of type II FIPV receptor feline [aminopeptidase N] in feline macrophages . Positive_regulation ANPEP TNF 23360826 2754406 In contrast , knockout significantly *restored* [APN] expression 12 and 72 h after reperfusion , suggesting that other TNFR1 binding cytokines contribute to MI/R induced APN suppression . Positive_regulation ANXA1 FAS 12545171 1051108 engagement *induces* neurite growth through ERK activation and [p35] upregulation . Positive_regulation ANXA1 IL1B 11083278 750501 Similarly , significantly *increased* [annexin I] binding on OA FLS ; Positive_regulation ANXA1 TNF 18684973 1949187 *induced* a biphasic secretion of [annexin-1] from RA SF . Positive_regulation ANXA2 PLAT 22677557 2633343 *induced* the aggregation and interaction of [annexin A2] with integrin CD11b , and ablation of CD11b or administration of anti-CD11b neutralizing antibody abolished the effect of tPA . Positive_regulation ANXA5 CAPN8 10446398 636748 Inhibition of platelet activity *suppressed* ionomycin enhanced microvesicle formation and ballooning of platelets , but not [annexin V] binding . Positive_regulation ANXA5 CST6 13679380 1164657 Overexpression of the gene also *caused* fragmentation of nuclei , the appearance of [annexin V] , a change in the mitochondrial membrane potential , and activation of caspases . Positive_regulation ANXA5 FAS 17975479 1820659 TNF-alpha and , but not lipopolysaccharide , *induced* [annexin-V] binding at 6 hours in C/EBPbeta wild type stellate cell . Positive_regulation ANXA5 FAS 9079812 420762 On the other hand , BM CD38hi cells showed neither CD95 expression nor *induced* [annexin V] binding . Positive_regulation ANXA5 TNF 10617950 657249 Our results indicated that linoleic acid and independently , but more markedly in concert , up-regulated caspase-3 activity and *induced* [annexin V] binding and DNA fragmentation . Positive_regulation ANXA5 TNF 11053415 786177 *induced* increases in [annexin V] binding to neutrophils were attenuated by blocking antibodies to beta2 integrins , and the caspase-3 cleavage was attenuated by tyrphostin A9 . Positive_regulation ANXA5 TNF 15905877 1465004 [Annexin V-binding] *induced* by STS or was largely suppressed by glycolysis inhibition . Positive_regulation ANXA5 TNF 17975479 1820658 and FAS , but not lipopolysaccharide , *induced* [annexin-V] binding at 6 hours in C/EBPbeta wild type stellate cell . Positive_regulation ANXA6 ANGPT1 16061664 1439088 [p70 S6 kinase (p70 S6K)] was *activated* by , although this activation was blocked by a PI3K inhibitor , LY294002 . Positive_regulation ANXA6 EPHB2 10212283 607891 and 3 ) dependent eIF4E phosphorylation but not PI3-kinase dependent [p70] ( S6k ) *activation* correlates with PGF2alpha induced global protein synthesis and bFGF-2 expression in VSMC . Positive_regulation ANXA6 EPHB2 10753954 682480 Addition of a selective inhibitor of phosphorylation ( PD98059 ) *prevented* the subsequent phosphorylation of [p70] ( S6k ) and the increase in p21 protein . Positive_regulation ANXA6 EPHB2 11872747 929645 These results indicate that both and PI3-K/AKT pathways are *required* for optimal IL-6 induced [p70] activity , but PI3-K/AKT is sufficient for 4E-BP1 phosphorylation . Positive_regulation ANXA6 EPHB2 18243130 1871433 Moreover , inhibition of could *repress* the activation of [p70S6K] , an important kinase in cardiac proliferation , and AICAR could also inhibit p70S6K phosphorylation . Positive_regulation ANXA6 GPR115 9299479 453598 Wortmannin-sensitive *activation* of [p70S6-kinase] and MAP-kinase by the , G/CCKB . Positive_regulation ANXA6 GPR132 9299479 453587 Wortmannin-sensitive *activation* of [p70S6-kinase] and MAP-kinase by the , G/CCKB . Positive_regulation ANXA6 GPR87 9299479 453667 Wortmannin-sensitive *activation* of [p70S6-kinase] and MAP-kinase by the , G/CCKB . Positive_regulation ANXA6 IL1B 16499573 1528906 When infected HeLa cells were co-cultured with THP-1 cells , IL-6 and IL-8 secretion was sustained , expression followed a bell shaped curve and IL-10 , [IL-12p70] and TNF-alpha synthesis was down *regulated* . Positive_regulation ANXA6 MAP2K6 12629037 1072244 In other groups , L-NAME was also used in combination with a [p70S6K] *inhibitor* ( rapamycin ) , a inhibitor ( PD98059 ) , and hydralazine . Positive_regulation ANXA6 MAP2K6 15304500 1322344 Selective inhibitors *attenuated* TGFalpha mediated basal activation of [p70S6K] ( S6K ) specifically at Thr-389 , indicating that this S6K site is downstream of ERK/MAPK signaling . Positive_regulation ANXA6 PLAU 16826166 1638588 Ganglioside GM3 promotes carcinoma cell proliferation via *induced* extracellular signal regulated kinase independent [p70S6] kinase signaling . Positive_regulation ANXA6 SPHK1 21435724 2416925 To investigate the immune modulatory *role* of as opposed to SphK2 specifically for the Th1 propagating [IL-12p70] we compared WT and SphK1 ( -/- ) splenocytes and Flt3-ligand differentiated BMCs of WT and SphK1 ( -/- ) , representing dendritic cells as major producers of IL-12p70 , incubated with LPS . Positive_regulation ANXA6 SPHK1 21435724 2416937 To further characterize *dependent* [IL-12p70] regulation we exogenously applied S1P , SEW2871 and the new potent S1P1 agonist CYM5442 . Positive_regulation ANXA6 STK39 11713255 903954 We found that the MLK3 *activated* JNK and [p70] ( S6K ) , whereas activation of p70 ( S6K ) by Rac ( 61L ) was significantly inhibited by dominant negative MLK3 . Positive_regulation ANXA6 TLR7 16009271 1431431 However , [IL-12p70] production in *response* to stimulating agents plus IFN-gamma was consistently lower in AIMV medium although also under serumfree culture conditions , nanogram quantities of IL-12 were produced . Positive_regulation ANXA6 TLR7 16751389 1570995 T cell independent , *induced* [IL-12p70] production in primary human monocytes . Positive_regulation ANXA6 TLR7 16751389 1571029 [IL-12p70] production in peripheral blood myeloid dendritic cells *required* combined stimulation of ligands together with TLR4 or with TLR3 ligands . Positive_regulation ANXA6 TLR7 16751389 1571032 In the presence of T cell derived IL-4 , but not IFN-gamma , stimulation with ligands was *sufficient* to stimulate [IL-12p70] production . Positive_regulation ANXA6 TLR7 18271077 1865816 Stimulation with TLR2 , TLR4 and ligands , as well as TLR3 ligand , *resulted* in significantly lower production of TNF-alpha , but neither IL-6 nor [IL-12p70] , by DCs from XLA patients in comparison to normal controls . Positive_regulation ANXA6 TLR7 19917677 2166660 In *response* to most ligands , neonatal innate immune cells , including monocytes and conventional and plasmacytoid dendritic cells produced less [IL-12p70] and IFN-alpha ( and consequently induced less IFN-gamma ) , moderately less TNF-alpha , but as much or even more IL-1beta , IL-6 , IL-23 , and IL-10 than adult cells . Positive_regulation ANXA6 TLR7 22685028 2659149 This indicates that IFN-a increased the sensitivity of monocytes to IL-10 , and as a result , *induced* [IL-12p70] by IFN pretreated cells was suppressed . Positive_regulation ANXA6 TLR7 22685028 2659179 In summary , we demonstrate that one of the consequences of priming human APCs with IFN is to promote the cells ' sensitivity to IL-10 , which leads to the inhibition of *induced* [IL-12p70] production . Positive_regulation ANXA6 TLR7 22896020 2677819 The combination of ligands for and TLR3 *led* to synergistic secretion of both IL-23 and [IL-12p70] from all subjects ; Positive_regulation ANXA6 TLR7 23755218 2797757 The aim of our study was to define the relative contribution of age and clinical status on *induced* interleukin [(IL)-12p70] and IL-23 production as these cytokines play an important role in the protection against intracellular and extracellular pathogens , respectively . Positive_regulation ANXA6 TNF 12871593 1114123 Interestingly , we have found that IL-12 [p70] , p402 ( the p40 homodimer ) and p40 ( the p40 monomer ) dose-dependently *induced* the production of and the expression of TNF-alpha mRNA in BV-2 microglial cells . Positive_regulation ANXA6 TNF 15683451 1370614 Polyriboinosinic polyribocytidylic acid ( Poly I:C ) + *induced* significant IL-12 [p70] secretion , which was increased after addition of a decoy IL-10 receptor . Positive_regulation ANXA6 TNF 17971516 1859765 *activated* two signaling cascades : 1 ) ERK1/2 and its target eIF4E and 2 ) Akt and its downstream effectors GSK-3 , [p70] ( S6K ) , and 4E-BP1 . Positive_regulation ANXA6 TNF 19567381 2185606 Similar to rapamycin , everolimus and zotarolimus abrogated *induced* [p70S6K] phosphorylation under these conditions . Positive_regulation ANXA6 TNF 21705614 2465729 Furthermore , luteolin inhibited *induced* phosphorylation of mitogen activated protein kinase/extracellular signal regulated kinase ( ERK ) kinase 1/ERK/p90 ( RSK ) , mitogen activated protein kinase kinase 4/c-Jun N-terminal kinase/c-Jun , and [Akt/p70] ( S6K ) . Positive_regulation AOC2 MAOA 3945672 56798 The present results indicate that both inhibitors also *inhibit* [SSAO] in vitro , but their properties as SSAO inhibitors differ from those as MAO-A inhibitors . Positive_regulation AOC3 SELL 8627168 355817 We also show that is not *required* for binding of activated lymphocytes to [VAP-1] under conditions of shear stress . Positive_regulation AP1B1 EPHB2 10498647 647615 In the *presence* of the inhibitor , binding of the [AP-1 complex] and of STAT1 to the related regulatory elements was inhibited . Positive_regulation AP1B1 EPHB2 12594266 1060833 Interestingly , transient activation *resulted* in altered AP-1 DNA binding activity and the induction of an [AP-1 complex] that was devoid of Fos protein and consisted of Jun-Jun dimers . Positive_regulation AP1G1 EPHB2 10498647 647616 In the *presence* of the inhibitor , binding of the [AP-1 complex] and of STAT1 to the related regulatory elements was inhibited . Positive_regulation AP1G1 EPHB2 12594266 1060835 Interestingly , transient activation *resulted* in altered AP-1 DNA binding activity and the induction of an [AP-1 complex] that was devoid of Fos protein and consisted of Jun-Jun dimers . Positive_regulation AP5M1 TNFSF10 23665015 2791274 We found that [MUDENG] is rapidly processed in *response* to in Jurkat and BJAB cells with time line similar to that of caspase activation . Positive_regulation APBB1 RASD1 18922798 1994420 interacts with FE65 to *regulate* [FE65-amyloid] precursor protein dependent transcription . Positive_regulation APC AXIN2 10698523 671861 Axin- ( 298-506 ) or ( 298-832 ) , which has the GSK-3beta- and beta-catenin- but not APC binding sites , did not *enhance* GSK-3beta dependent phosphorylation of either APC- ( 1211-2075 ) or [APC-] ( 959-1338 ) . Positive_regulation APC AXIN2 10698523 671865 Furthermore , beta-catenin stimulated the phosphorylation of APC- ( 959-1338 ) and [APC-] ( 1211-2075 ) by GSK-3beta in the *presence* of . Positive_regulation APC AXIN2 10722668 677140 These results suggest that [APC] *requires* interaction with and beta-catenin to down-regulate beta-catenin . Positive_regulation APC F2R 12052963 950998 Thus , the prototypical is the *target* for EPCR dependent [APC] signaling , suggesting a role for this receptor cascade in protection from sepsis . Positive_regulation APC F2R 23149848 2707422 [APC] 's activities , but not thrombin 's , *require* located in caveolae . Positive_regulation APC F2R 23809128 2808148 Recent insights , such as non-canonical *activation* of at Arg46 by [APC] and biased PAR1 signaling , provided better understanding of the molecular mechanisms by which APC elicits cytoprotective signaling through cleavage of PAR1 . Positive_regulation APC ID1 18372912 1938163 During late mitosis , binds to Cdh1 and disrupts the interaction between Cdh1 and APC , *resulting* in suppression of [APC] ( Cdh1 ) activity . Positive_regulation APC ITGAL 12646624 1070217 Gammadelta T cells formed stable conjugates with pamidronate pulsed human tumor cells and both conjugate formation and gammadelta T cell activation were inhibited significantly by anti-LFA-1 mAb , suggesting the requirement of *mediated* interaction with [APC] for efficient gammadelta T cell activation . Positive_regulation APC ITGAL 15210787 1262069 The beta ( 2 ) integrin is *involved* in T [cell-APC] interactions , but the roles of CD11b , CD11c , and CD11d in such interactions have not been examined . Positive_regulation APC ITGAL 1971292 132809 Similarly , anti-LFA-1 mAb inhibited the response of T cells to Ag presented by the wild-type A20 to a much greater degree than by the mutant cells , indicating that is *involved* in interaction of T cells with the former , but not latter , [APC] . Positive_regulation APC ITGB2 20458145 2268636 Here , we report that the antiinflammatory activity of [APC] on macrophages is *dependent* on integrin , but not on endothelial protein C receptor (EPCR) . Positive_regulation APC TLR7 12778463 1095533 Stimulation of by pathogen derived compounds *leads* to activation of [APC] , facilitating the induction of protective immunity . Positive_regulation APC TLR7 17918201 1819320 *mediated* stimulation of [APC] : Distinct cytokine responses of B cells and dendritic cells . Positive_regulation APC TLR7 18056339 1833432 Finally , we could replace the requirement for mediated [APC] *activation* in soluble-Ag induced T cell expansion and differentiation , by maintaining the Ag depot in vivo using repeated immunizations . Positive_regulation APC TNF 11182219 785388 In [antigen presenting cells (APC)] , *increased* antigen presentation , notably by up-regulation of HLA class II expression . Positive_regulation APCS CD14 22974465 2673867 Lastly , we discuss the observation that negatively *regulates* alternative activation of [APCs] during helminth infection . Positive_regulation APCS PECAM1 20978210 2344219 We propose that these effects are dependent on an as yet unrecognized role for *mediated* homophilic interactions between T cells and [antigen presenting cells (APCs)] during priming . Positive_regulation APCS TLR7 18077358 1836867 We report that *activation* of human [APCs] by modulates the lipid biosynthetic pathway , resulting in enhanced recognition of CD1d associated lipids by iNKT cells , as defined by IFN-gamma secretion . Positive_regulation APCS TLR7 18820644 1987661 Here , we demonstrate that soluble factor ( s ) produced by *activated* [APCs] suppress activation induced cell death ( AICD ) . Positive_regulation APCS TLR7 20980632 2348918 These studies suggest that some age associated immune defects may be overcome by targeted *activation* of [APCs] by ligands . Positive_regulation APCS TNF 11493458 845849 It is demonstrated that similar to interferon gamma (IFN-gamma) , *induces* coordinated changes at different steps of the major histocompatibility complex ( MHC ) class I processing and presentation pathway in nonprofessional [antigen presenting cells (APCs)] . Positive_regulation APEX1 TNF 19376732 2081864 *induced* IL-8 expression in gastric epithelial cells : role of reactive oxygen species and [AP endonuclease-1/redox] factor (Ref)-1 . Positive_regulation APLN EPHB2 24770651 2937029 The AngII inhibition mediated beneficial effects are likely attributable , at least in part , to restoration of *dependent* [apelin/APJ] expression in diet induced obesity related hypertension . Positive_regulation APLN TNF 18457011 1840376 In this regard , expression of [apelin] gene in adipose tissue is *increased* by insulin and . Positive_regulation APOA1 GLP1R 21239158 2504639 These data indicate that [chylomicron] formation is essential and activation of the is *involved* in activation of the nutritional anti-inflammatory pathway by lipid enriched nutrition . Positive_regulation APOA1 LIPG 14517167 1151944 Overexpression of markedly *reduces* plasma levels of HDL cholesterol and [apoA-I] in mice , but the mechanisms of this effect remain unknown . Positive_regulation APOA1 PCSK9 23422832 2755334 Moreover , exogenous altered the activity of HMG-CoA reductase and acylcoenzyme A : cholesterol acyltransferase , and was able to *enhance* [chylomicron] secretion by positively modulating lipids and apolipoprotein B-48 biogenesis . Positive_regulation APOA1 RARB 9392425 467754 iv ) RLR alpha and/or and RXR alpha are *involved* in the activation of [apoA-I] expression by retinoids . Positive_regulation APOA1 TNF 20599735 2290821 Stimulation of HepG2 cells by *leads* to activation of the distal alternative [apoA-I] promoter and downregulation of the proximal alternative and the canonical apoA-I promoters . Positive_regulation APOA2 GLP1R 21239158 2504640 These data indicate that [chylomicron] formation is essential and activation of the is *involved* in activation of the nutritional anti-inflammatory pathway by lipid enriched nutrition . Positive_regulation APOA2 NR2F1 1639815 194722 The finding that HNF-4 , ARP-1 , EAR-2 and can *regulate* the expression of the apoB , apoCIII , and [apoAII] genes suggest that these nuclear hormone receptors may be an important part of the signal transduction pathways modulating lipid metabolism and cholesterol homeostasis . Positive_regulation APOA2 PCSK9 23422832 2755335 Moreover , exogenous altered the activity of HMG-CoA reductase and acylcoenzyme A : cholesterol acyltransferase , and was able to *enhance* [chylomicron] secretion by positively modulating lipids and apolipoprotein B-48 biogenesis . Positive_regulation APOA4 GLP1R 21239158 2504641 These data indicate that [chylomicron] formation is essential and activation of the is *involved* in activation of the nutritional anti-inflammatory pathway by lipid enriched nutrition . Positive_regulation APOA4 MMP7 22170214 2558017 Further , *mediated* cleavage of [apoA-IV] resulted in a rapid loss of its intrinsic anti-oxidant activity . Positive_regulation APOA4 PCSK9 23422832 2755336 Moreover , exogenous altered the activity of HMG-CoA reductase and acylcoenzyme A : cholesterol acyltransferase , and was able to *enhance* [chylomicron] secretion by positively modulating lipids and apolipoprotein B-48 biogenesis . Positive_regulation APOB ALOX5 1729678 181248 Thus we conclude that neither <5-lipoxygenase> nor 15-lipoxygenase is *required* for modification of [LDL] by cultured cells . Positive_regulation APOB CAPN8 18624772 2179407 *Activation* of protease by oxidized and glycated [LDL] increases the degradation of endothelial nitric oxide synthase . Positive_regulation APOB CD14 23880187 2821416 Cell-free experiments performed in CD14 coated microtiter wells confirmed that was *involved* in [LDL] ( - ) binding . Positive_regulation APOB CTGF 22422617 2588064 Low-density [lipoprotein] *induced* expression of via transactivation of sphingosine 1-phosphate receptors in mesangial cells . Positive_regulation APOB CTGF 22422617 2588067 We recently reported that [low-density lipoproteins (LDL)] *induced* expression of in aortic endothelial cells . Positive_regulation APOB EDN2 24315856 2904903 Low density [lipoprotein] *induces* upregulation of vasoconstrictive type B receptor expression . Positive_regulation APOB EPHB2 17002919 1618174 These results suggest that phosphorylation of is *induced* by [Ox-LDL] through the induction of the TGF-beta signaling pathway and that activated ERK , in turn , participates in the Ox-LDL induced Smad3 activation and subsequent PAI-1 gene expression in mesangial cells . Positive_regulation APOB EPHB2 18061125 1846788 [Ox-LDL] stimulation of plasminogen activator inhibitor-1 ( PAI-1 ) expression via transforming growth factor-beta ( TGF-beta ) /Smad signaling in mesangial cells *required* activation of extracellular signal regulated kinase ( ) . Positive_regulation APOB EPHB2 19169357 2027646 These early events included the trafficking of [apolipoprotein B] , a structural component of TRL , from apical towards secretory domains , and the rapid , dose dependent *activation* of and p38MAPK . Positive_regulation APOB F3 7240413 15669 Very low density [lipoprotein] *induced* a maximal 6.7-fold increase in the expression of a activity , which was consistent with tissue factor , in that it was dependent on Factors VII , X , and II . Positive_regulation APOB FAS 12235183 988979 These studies demonstrate that unsaturated drive the esterification reaction and *enhance* [lipoprotein] cholesterol secretion by the liver under conditions where cholesterol balance across this organ is constant . Positive_regulation APOB FAS 20036856 2192498 Electronegative [LDL] *induces* and modifies gene expression in mononuclear cells . Positive_regulation APOB G0S2 23951308 2831722 Hepatic overexpression *resulted* in an increase in plasma Low-density lipoprotein (LDL)/Very-Low-density ( VLDL ) [lipoprotein] cholesterol level . Positive_regulation APOB GLP1R 19957161 2204071 The is *essential* for postprandial [lipoprotein] synthesis and secretion in hamsters and mice . Positive_regulation APOB IL1B 15662752 1350345 It became known , that oxidized LDL can inhibit LPS induced binding of the NF-kappaB to DNA and the subsequent expression of TNF-alpha and in macrophages as well as oxidized [LDL] modulates *activation* of NF-kappaB in mononuclear phagocytes by altering the degradation of I-kappaBs . Positive_regulation APOB IL1B 16087165 1443236 Very low-density [lipoprotein] *induces* expression in macrophages . Positive_regulation APOB IL1B 1629217 191850 The purpose of the present study was to determine whether modified [LDL] could also *induce* macrophage release of , a cytokine which enhances vascular smooth muscle cell proliferation , another feature of the atherosclerotic process . Positive_regulation APOB IL1B 1816321 177441 [Low density lipoprotein (LDL)] , acetylated-LDL , or malondialdehyde-LDL did not *induce* mRNA expression or affect the expression in response to lipopolysaccharide (LPS) . Positive_regulation APOB IL1B 18167199 1838736 However , further *increased* intracellular cholesterol level in the presence of [LDL] by increasing both LDL receptor mRNA and protein expression in HepG2 . Positive_regulation APOB IL1B 7704977 297597 In conclusion , human macrophages are efficiently *activated* by [LDL-IC] , as reflected by the release of and TNF alpha and by the release of oxygen active radicals . Positive_regulation APOB IL1B 8006515 258093 Nitrone spin trap lipophilicity as a determinant for inhibition of low density [lipoprotein] oxidation and *activation* of release from human monocytes . Positive_regulation APOB IL1B 8014577 262526 Oxidized [low density lipoproteins (LDL)] *induce* the release of from human peripheral blood mononuclear cells , a process that may contribute to atherogenesis . Positive_regulation APOB IL1B 8349628 227082 Tumor necrosis factor-alpha (TNF) and *increased* [LDL] binding to HepG2 cells in a dose-responsive manner . Positive_regulation APOB LBP 15784577 1386071 The presence of LPS on HDL further enhanced *dependent* interactions of [LDL] with HDL and increased the stability of the HDL-LDL complexes . Positive_regulation APOB LBP 1883513 165626 Compared to *induction* of TNF-alpha , [LPS-lipoprotein] complexes are as much as 10,000-fold less active . Positive_regulation APOB LIPG 17822686 1817466 *enhances* low density [lipoprotein] binding and cell association in THP-1 macrophages . Positive_regulation APOB LIPG 22972429 2706276 *regulates* plasma high-density [lipoprotein-cholesterol] ( HDL-C ) levels by promoting HDL catabolism . Positive_regulation APOB MUC16 15485666 1320701 Nontypeable Haemophilus influenzae [lipoprotein] P6 *induces* MUC5AC transcription via TLR2-TAK1 dependent p38 MAPK-AP1 and IKKbeta-IkappaBalpha-NF-kappaB signaling pathways . Positive_regulation APOB PCSK9 17380167 1715369 Expression of normally downregulates the LDL-receptor pathway by indirectly causing degradation of LDL-receptor protein , and loss-of-function mutations in PCSK9 *result* in low plasma [LDL] levels . Positive_regulation APOB PCSK9 20172854 2236496 Consequently , the *role* of in modulating circulating [LDL] makes it a promising therapeutic target for treating hypercholesterolemia and coronary heart disease . Positive_regulation APOB PCSK9 23115612 2695872 The *role* of in the regulation of circulating low density [lipoprotein-cholesterol] ( LDL-c ) levels is ascribed to binding of circulating PCSK9 to the LDL receptor (LDLR) and subsequent lysosomal degradation of LDLR . Positive_regulation APOB PCSK9 24315769 2926767 Because PCSK9 ( proprotein convertase subtilisin/kexin type 9 ) promotes degradation of LDLR , we tested the hypothesis that elevation of [LDL] cholesterol levels in patients with nephrotic syndrome and PD patients may be *due* to increased levels . Positive_regulation APOB PLAT 15708180 1372947 The total cholesterol , [LDL-cholesterol] and sVCAM-1 ( from 394.4+/-251.7 to 321.0+/-198.9 ng/ml , p < 0.05 ) all decreased significantly and the ( from 9.47+/-3.57 to 11.62+/-3.99 ng/ml , p < 0.05 ) *increased* significantly after atorvastatin treatment . Positive_regulation APOB SPHK1 16516816 1530820 Oxidized [LDL] immune complexes *induce* release of in human U937 monocytic cells . Positive_regulation APOB TNF 10480607 643527 These purified human islet MVEC ( HI-MVEC ) express von Willebrand factor , take up high levels of acetylated [LDL] , and upregulate endothelial cell leukocyte adhesion molecule 1 in *response* to . Positive_regulation APOB TNF 10627511 659111 There was no effect of hormone replacement on rate of *induced* [LDL] accumulation ( P = 0.451 ) , while incubation of LDL with 65 pg/ml estradiol attenuated the TNF effect ( P < 0.01 ) . Positive_regulation APOB TNF 11583711 865796 Oxidized [LDL] , as well as a combination of cholesterol and 25-hydroxycholesterol , *induced* and interleukin-1 beta (IL-1 beta) mRNA as measured by quantitative real time PCR , by a maximum of two- to fourfold following a 24-h incubation . Positive_regulation APOB TNF 15021964 1221909 In MDM , intracellular and IL-12 expression was *induced* by mannan , native and modified [LDL] , but not other ligands . Positive_regulation APOB TNF 15319868 1286501 The 19-kDa [lipoprotein] proapoptotic signal was *mediated* by Toll-like receptor 2 but not by . Positive_regulation APOB TNF 15662752 1350344 It became known , that oxidized LDL can inhibit LPS induced binding of the NF-kappaB to DNA and the subsequent expression of and interleukin-1beta in macrophages as well as oxidized [LDL] modulates *activation* of NF-kappaB in mononuclear phagocytes by altering the degradation of I-kappaBs . Positive_regulation APOB TNF 17405916 1722087 *Upregulation* of [apolipoprotein B] secretion , but not lipid , by in rat hepatocyte cultures in the absence of extracellular fatty acids . Positive_regulation APOB TNF 19154986 2027110 The Mtb 19 kDa [lipoprotein] *induced* release of in a manner dependent on both TLR2 and RP105 , and macrophage activation by Mtb lacking mature lipoproteins was not RP105 dependent . Positive_regulation APOB TNF 2269351 147326 Acetyl [LDL] also *induced* the expression of immunoreactive , reaching a sevenfold maximum above control at 12 hours following a 6 hour exposure period . Positive_regulation APOB TNF 7704977 297596 In conclusion , human macrophages are efficiently *activated* by [LDL-IC] , as reflected by the release of IL-1 beta and and by the release of oxygen active radicals . Positive_regulation APOB TNF 7861934 287170 In order to know whether *upregulates* [LDL] receptors by depletion of the cellular cholesterol content , the present experiments were designed to study the temporal relationship between TNF stimulated expression of LDL receptor activity and TNF induced changes in lipid synthesis and secretion in an in vitro setting by using Hep G2 cells ( a highly differentiated human hepatoma cell line ) as a hepatocyte model . Positive_regulation APOB TNF 8349628 227081 and interleukin-1 beta (IL-1) *increased* [LDL] binding to HepG2 cells in a dose-responsive manner . Positive_regulation APOB TNF 8387950 218075 *stimulated* enhancement of low-density [lipoprotein] binding occurred at all stages of cell growth . Positive_regulation APOB TNF 8387950 218077 Competition experiments using unlabeled low-density lipoprotein and blockage experiments with a monoclonal low-density lipoprotein receptor antibody showed that *stimulated* low-density [lipoprotein] binding takes place through stimulation of low-density lipoprotein receptors . Positive_regulation APOB TNF 9578494 503261 We show that lipopolysaccharide-free actetylated [low-density lipoprotein (LDL)] , but not native LDL , stimulates secretion by rat peritoneal macrophages and the signal-transduction pathways *involved* . Positive_regulation APOB TNF 9840652 552788 In vitro studies with cultured human skin fibroblasts , human umbilical vein endothelial cells , and HepG2 hepatoma cells showed that *increased* the degradation of 125I labeled low-density [lipoprotein] in all the cell lines tested . Positive_regulation APOB UNC5B 23599441 2783861 Indeed , using promoter-luciferase reporter genes , we show that Ntn1- and activities are *induced* by oxidized low-density [lipoprotein] and require HIF-1a . Positive_regulation APOBEC2 IL1B 16427049 1515825 We demonstrate that [APOBEC2] expression is strongly enhanced in *response* to both tumour necrosis factor-alpha (TNF-alpha) and . Positive_regulation APOBEC2 TNF 16427049 1515824 We demonstrate that [APOBEC2] expression is strongly enhanced in *response* to both and interleukin-1beta . Positive_regulation APOBEC2 TNF 16427049 1515828 Inhibition of NF-kappaB activation invariably blocks *induced* [APOBEC2] expression . Positive_regulation APOBEC2 TNF 21469143 2538522 Together with the fact that the proinflammatory cytokine *induces* ectopic expression of [APOBEC2] in hepatocytes , our findings indicate that aberrant APOBEC2 expression causes nucleotide alterations in the transcripts of the specific target gene and could be involved in the development of human hepatocellular carcinoma through hepatic inflammation . Positive_regulation APOBEC3G TNF 19027180 2022804 The expression of [APOBEC3G] could be *up-regulated* in human neuronal cells ( NT2-N ) and astrocytes ( U87-MG ) by interferons ( IFN-alpha , beta and gamma ) , interleukin-1 (IL-1) , and . Positive_regulation APOC2 GLP1R 21239158 2504642 These data indicate that [chylomicron] formation is essential and activation of the is *involved* in activation of the nutritional anti-inflammatory pathway by lipid enriched nutrition . Positive_regulation APOC2 PCSK9 23422832 2755337 Moreover , exogenous altered the activity of HMG-CoA reductase and acylcoenzyme A : cholesterol acyltransferase , and was able to *enhance* [chylomicron] secretion by positively modulating lipids and apolipoprotein B-48 biogenesis . Positive_regulation APOC3 FOXO1 15546000 1337989 Likewise , also *mediated* insulin action on intestinal [apoC-III] expression in enterocytes . Positive_regulation APOC3 FOXO1 15546000 1337991 Furthermore , elevated production in liver *augmented* hepatic [apoC-III] expression , resulting in increased plasma triglyceride levels and impaired fat tolerance in mice . Positive_regulation APOC3 GLP1R 21239158 2504643 These data indicate that [chylomicron] formation is essential and activation of the is *involved* in activation of the nutritional anti-inflammatory pathway by lipid enriched nutrition . Positive_regulation APOC3 NR2F1 1639815 194724 The finding that HNF-4 , ARP-1 , EAR-2 and can *regulate* the expression of the apoB , [apoCIII] , and apoAII genes suggest that these nuclear hormone receptors may be an important part of the signal transduction pathways modulating lipid metabolism and cholesterol homeostasis . Positive_regulation APOC3 PCSK9 23422832 2755338 Moreover , exogenous altered the activity of HMG-CoA reductase and acylcoenzyme A : cholesterol acyltransferase , and was able to *enhance* [chylomicron] secretion by positively modulating lipids and apolipoprotein B-48 biogenesis . Positive_regulation APOE CLU 15519757 1328974 In contrast to adult glia , neonatal secretion did not respond to IL-1 beta , IL-6 , or TNFalpha , and [ApoE] secretion from neonatal glia was slightly *increased* by IL-6 . Positive_regulation APOE EPHB2 22171672 2520239 Inhibitors of MAPK-p38 , , and JNK *inhibited* [ApoE] induction by all these agents except glutamate , which was sensitive only to inhibitors of ERK and JNK . Positive_regulation APOE GLP1R 21239158 2504644 These data indicate that [chylomicron] formation is essential and activation of the is *involved* in activation of the nutritional anti-inflammatory pathway by lipid enriched nutrition . Positive_regulation APOE PCSK9 23422832 2755339 Moreover , exogenous altered the activity of HMG-CoA reductase and acylcoenzyme A : cholesterol acyltransferase , and was able to *enhance* [chylomicron] secretion by positively modulating lipids and apolipoprotein B-48 biogenesis . Positive_regulation APOE TNF 1709937 158077 Human recombinant , a potent inhibitor of LPL gene transcription , *had* no effect on adipocyte [apoE] mRNA levels . Positive_regulation APOL1 TNF 18927493 1982085 To further investigate regulation of ApoL1 expression , we showed that [ApoL1] is *inducible* by interferon-gamma and in human umbilical vein endothelial cells , suggesting that ApoL1 may play a role in cytokine induced inflammatory response . Positive_regulation APP CAPN8 10873581 708428 Finally , the secretion of [APP] from intact platelets was *inhibited* by cell-permeable inhibitors . Positive_regulation APP CAPN8 15020222 1221453 In this study , we observed that : ( a ) Phorbol 12,13-dibutyrate ( PDBu ) -stimulated [APP] secretion in cultured SH-SY5Y neuroblastoma and fibroblast cells was *blocked* by EGTA and inhibitors in a concentration dependent manner , but not by other protease inhibitors . Positive_regulation APP CD14 9510153 491824 Since LPS induces high levels of these cytokines after its interaction with CD14 , a protein expressed on the surface of monocytes and neutrophils , it has been assumed that *mediates* the LPS induction of [APP] expression . Positive_regulation APP EPHB2 18275940 1872073 We demonstrate additionally that specific inhibition during staurosporine induction , with serum-free conditions , *results* in down-regulation of [APP] phosphorylation at T668 , together with attenuation of the increased Abeta-secretory response . Positive_regulation APP EPHB2 9390997 467679 Furthermore , overexpression of a kinase-inactive MEK mutant inhibited phorbol ester stimulation of [APP] secretion and *activation* of in human embryonic kidney cell lines . Positive_regulation APP F2R 10235452 611686 The secretion of [APP] is *mediated* , since it is inhibited by the thrombin antagonist N-Acetyl-D-Phe-Pro-1-Amido-4-Guanidino-Butyl-1-Boronic Acid . Positive_regulation APP IL1B 10355633 618190 The *induced* [PN-II] secretion was significantly inhibited by relatively high concentrations ( 50-200 microg/ml ) of aprotinin , a serine proteinase inhibitor , in a dose dependent manner without obvious cell-toxic effects . Positive_regulation APP IL1B 10636471 576792 In this study , we investigated the effects of antisense oligonucleotide ( AO ) on the overexpression of [APP] *induced* by and NGF . Positive_regulation APP IL1B 10636471 576794 Using phosphorothioate-oligonucleotides against initiation codon significantly reduced the protein levels of [APP] *induced* by NGF and to basal level in PC12 cell culture systems . Positive_regulation APP IL1B 12542857 1029286 In vitro data indicate that expression of [APP] may be *regulated* in part by the inflammatory cytokine . Positive_regulation APP IL1B 15880353 1411402 Short-term *increases* the release of secreted [APP] ( alpha ) via MEK1/2 dependent and JNK dependent alpha-secretase cleavage in neuroglioma U251 cells . Positive_regulation APP IL1B 17549252 1752483 A beneficial *role* for in [Alzheimer disease] ? Positive_regulation APP IL1B 18262272 1884931 In PHH , several [APP] like CRP , haptoglobin (HP) , lipopolysaccharide binding protein (LBP) or hepcidin ( HAMP ) were *regulated* similarly by and IL-6 , though signal transduction pathways of these cytokines are different . Positive_regulation APP IL1B 20395292 2267299 In addition , miR-101 contributed to the regulation of [APP] in *response* to the proinflammatory cytokine ( IL-lbeta ) . Positive_regulation APP IL1B 7693853 234251 This study was undertaken to determine whether [acute phase proteins (APP)] *induce* the synthesis of and its specific antagonist , IL-1 receptor antagonist (IL-1Ra) , in human peripheral blood mononuclear cells ( PBMC ) . Positive_regulation APP IL1B 7695605 297260 Enhanced processing of [APP] *induced* by can be reduced by indomethacin and nordihydroguaiaretic acid . Positive_regulation APP IL1B 7695605 297261 In addition , as reported previously in HUVEC cells , *increases* the secretion of [APP] in PC12 cells . Positive_regulation APP MAP2K6 9390997 467685 Furthermore , overexpression of a kinase-inactive mutant *inhibited* phorbol ester stimulation of [APP] secretion and activation of ERK in human embryonic kidney cell lines . Positive_regulation APP SORL1 19364929 2058673 T o *detect* soluble LR11 and [APP] in cerebrospinal fluid (CSF) from patients with AD and control subjects , as ( like beta-amyloid precursor protein ) is cleaved near the membrane to release a large N-terminal fragment that is secreted to media from cultured cells . Positive_regulation APP TNF 11967279 933130 Both the cytokine interferon-gamma and the lysosomotropic drug chloroquine , but not the cytokines interleukin (IL)-1 , IL-6 , or , *induced* an accumulation of [APP] in newly formed multivesicular body-like organelles . Positive_regulation APP TNF 19862700 2165595 Interestingly , [APP] protein synthesis and mRNA expression were significantly *increased* by in a time dependent manner with maximal induction observed after 24 h of treatment . Positive_regulation APP TNF 19862700 2165597 Furthermore , *induced* [APP] mRNA expression dose-dependently with maximal 6.4-fold upregulation seen at 100 ng/ml effector . Positive_regulation APP TNF 19862700 2165598 Moreover , inhibitor experiments suggested that TNFalpha induced APP expression was mediated by nuclear factor kappa B. Taken together , we show for the first time a potent *upregulation* of [APP] by suggesting a potential role of this adipocyte secreted protein in TNFalpha induced insulin resistance and inflammatory disease . Positive_regulation APP TNF 22047170 2508333 stimulation significantly *increased* levels of astrocytic BACE1 , [APP] , and secreted Aß40 . Positive_regulation APP TNF 8564570 340517 IL1 and *mediated* stimulation of type 1 [APP] genes is synergistically enhanced by IL6 type cytokines . Positive_regulation APPL1 MMP28 24255018 2904162 Adiponectin *mediated* [APPL1-AMPK] signaling induces cell migration , activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation APPL1 MMP7 24255018 2904177 Adiponectin *mediated* [APPL1-AMPK] signaling induces cell migration , activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation AQP1 EPHB2 12600999 1079454 These data demonstrate that the activation of , p38 kinase , and JNK pathways and the hypertonicity response element in the AQP1 promoter are *involved* in hypertonicity induced [AQP1] expression in mIMCD-3 cells . Positive_regulation AQP1 HRH1 19443731 2107126 *induces* cytosolic calcium increase and [aquaporin] translocation in human salivary gland cells . Positive_regulation AQP1 TF 11479158 842119 After 24 hours of stimulation , *led* to a 2.4- and 2.2-fold increase in [AQP1] and APQ3 messenger RNA expression , whereas protein synthesis surged by 40.7 % +/- 2.48 % and 24.2 % +/- 0.9 % compared with control , respectively . Positive_regulation AQP1 TNF 12635141 1068490 In vitro studies revealed that both MIF and induced a small *increase* of [AQP1] synthesis in cultured endothelial cells . Positive_regulation AQP10 HRH1 19443731 2107113 *induces* cytosolic calcium increase and [aquaporin] translocation in human salivary gland cells . Positive_regulation AQP11 HRH1 19443731 2107114 *induces* cytosolic calcium increase and [aquaporin] translocation in human salivary gland cells . Positive_regulation AQP2 EPHB2 15494547 1359503 Inhibition of , p38 kinase , and phosphatidylinositol 3'-kinase ( PI 3-kinase ) activities *prevented* the insulin induced stimulation of [AQP2] expression , whereas inhibition of PKC has no effect . Positive_regulation AQP2 EPHB2 16844078 1613095 However , AVP also activated both ERK and CREB pathways , and inhibitor *attenuated* the upregulation of [AQP2] expression . Positive_regulation AQP2 HRH1 19443731 2107127 *induces* cytosolic calcium increase and [aquaporin] translocation in human salivary gland cells . Positive_regulation AQP3 EPHB2 16848764 1638626 MEK [ MAPK ( mitogen activated protein kinase ) /ERK ( extracellular-signal regulated kinase ) kinase ] inhibitor U0126 and PI3K ( phosphoinositide 3-kinase ) inhibitor LY294002 also *inhibited* EGF induced [AQP3] expression and cell migration . Positive_regulation AQP3 EPHB2 18636178 1937287 PD153035 , an EGFR inhibitor , and U0126 , an inhibitor , *inhibit* atRA induced upregulation of [AQP3] . Positive_regulation AQP3 EPHB2 18636178 1937289 Collectively , our results indicate that the effect of atRA on [AQP3] expression is at least partly *mediated* by signaling in cultured human skin keratinocytes . Positive_regulation AQP3 EPHB2 22886825 2715717 The inhibitor can *attenuate* the expression of [AQP3] , -5 , and -8 after hyperosmotic solution exposure . Positive_regulation AQP3 HRH1 19443731 2107128 *induces* cytosolic calcium increase and [aquaporin] translocation in human salivary gland cells . Positive_regulation AQP3 HSD11B2 17213730 1695864 A decreased expression of <11betaHSD2> may *result* in an upregulation of [AQP3] , in which AVP/cAMP dependent mechanisms are unlikely to be involved . Positive_regulation AQP3 MAP2K6 16848764 1638632 [ MAPK ( mitogen activated protein kinase ) /ERK ( extracellular-signal regulated kinase ) kinase ] /ERK inhibitor U0126 and PI3K ( phosphoinositide 3-kinase ) inhibitor LY294002 also *inhibited* EGF induced [AQP3] expression and cell migration . Positive_regulation AQP4 HRH1 19443731 2107129 *induces* cytosolic calcium increase and [aquaporin] translocation in human salivary gland cells . Positive_regulation AQP4 IL1B 16987239 1617784 *induces* the expression of [aquaporin-4] through a nuclear factor-kappaB pathway in rat astrocytes . Positive_regulation AQP4 IL1B 16987239 1617785 We tested the hypothesis that [AQP4] is induced in *response* to . Positive_regulation AQP4 IL1B 16987239 1617787 We found that expression of AQP4 mRNA and protein was significantly up-regulated by in cultured rat astrocytes , and that intracerebroventricular administration of IL-1beta *increased* the expression of [AQP4] protein in rat brain . Positive_regulation AQP4 IL1B 16987239 1617790 Inhibition of the nuclear factor-kappaB (NF-kappaB) pathway blocked the *induction* of [AQP4] by in a concentration dependent manner . Positive_regulation AQP4 IL1B 16987239 1617791 These findings show that *induces* expression of [AQP4] through a NF-kappaB pathway without involvement of de novo protein synthesis in rat astrocytes . Positive_regulation AQP4 IL1B 20132469 2235857 Notably , curcumin blocked *induced* [aquaporin-4] expression in cultured astrocytes , an effect mediated , at least in part , by reduced activation of the p50 and p65 subunits of nuclear factor kappaB . Positive_regulation AQP4 TNF 23494261 2853783 We also found that both NF?B and p38/MAPK pathways were involved in IL-1ß and *induced* [AQP-4] expression and that propofol functions as a dual inhibitor of NF?B and p38/MAPK pathways . Positive_regulation AQP5 CAPN8 24192288 2891612 Pretreatment of animals with two inhibitors , N-Ac-Leu-Leu-methininal (ALLM) and calpeptin , as well as a protein synthesis inhibitor , cycloheximide ( CHX ) , significantly *suppressed* the IPR induced [AQP5] degradation in the PG membrane fraction ; Positive_regulation AQP5 EPHB2 10722758 677290 This study demonstrates that [AQP5] is induced by hypertonic stress and that induction *requires* activation of extracellular signal regulated kinase ( ) . Positive_regulation AQP5 EPHB2 10722758 677291 ERK was selectively activated in MLE-15 cells by hypertonic stress , and inhibition of activation with two distinct mitogen activated extracellular regulated kinase kinase ( MEK ) inhibitors , U0126 and PD98059 , *blocked* [AQP5] induction . Positive_regulation AQP5 HRH1 19443731 2107130 *induces* cytosolic calcium increase and [aquaporin] translocation in human salivary gland cells . Positive_regulation AQP5 TNF 11279049 819478 Activation of the p55 receptor ( TNFR1 ) with an agonist antibody is *sufficient* to cause decreased [AQP5] expression , demonstrating that the TNF-alpha effect is mediated through TNFR1 . Positive_regulation AQP6 HRH1 19443731 2107131 *induces* cytosolic calcium increase and [aquaporin] translocation in human salivary gland cells . Positive_regulation AQP7 HRH1 19443731 2107132 *induces* cytosolic calcium increase and [aquaporin] translocation in human salivary gland cells . Positive_regulation AQP8 CAPN8 19193945 2049595 Inhibitory experiments suggest that a reduced *mediated* [AQP8] proteolysis could be involved . Positive_regulation AQP8 HRH1 19443731 2107133 *induces* cytosolic calcium increase and [aquaporin] translocation in human salivary gland cells . Positive_regulation AQP9 HRH1 19443731 2107134 *induces* cytosolic calcium increase and [aquaporin] translocation in human salivary gland cells . Positive_regulation AQP9 TNF 20181673 2236794 [AQP9] as an aquaglyceroporin was *induced* by . Positive_regulation AR ADRB2 18454446 1915998 The ( beta ( 2 ) -AR ) is a well-known *activator* of the [androgen receptor] . Positive_regulation AR ANKRD1 23811403 2820747 This investigation explored the effects of testosterone on Ankrd1 and Ankrd2 expression and determined whether or Ankrd2 binds to or *regulates* the transcriptional activity of the [androgen receptor (AR)] . Positive_regulation AR EPHB2 19946123 2190646 *regulates* calpain 2-induced [androgen receptor] proteolysis in CWR22 relapsed prostate tumor cell lines . Positive_regulation AR FOXA1 18178153 1856275 ( HNF-3alpha ) negatively *regulates* [androgen receptor] transactivation in prostate cancer cells . Positive_regulation AR FOXA1 21915096 2491962 Dual *role* of in [androgen receptor] binding to chromatin , androgen signalling and prostate cancer . Positive_regulation AR ID1 22819717 2670614 Activation of [androgen receptor] *induces* and promotes hepatocellular carcinoma cell migration and invasion . Positive_regulation AR PLAT 8119140 250591 Interestingly , whereas mRNA levels , like those of TGF beta 2 and -beta 3 , were barely detectable in adult prostatic tissues , mRNA levels for urokinase plasminogen activator , [androgen receptor] , and c-myc were readily *detected* and expressed in a lobe-specific fashion . Positive_regulation AR TNF 12706288 1082580 NF-kappaB and *stimulate* [androgen receptor] expression in Sertoli cells . Positive_regulation AR TNF 17968653 1826625 FSH-sensitive murine sertoli cell lines immortalized by human telomerase gene hTERT express the [androgen receptor] in *response* to stimulation . Positive_regulation AR TNF 17968653 1826627 The expression of the [androgen receptor] in both B6Sc-2 and B6Sc-3 cells could be *induced* by treatment . Positive_regulation AR UGT1A7 18471784 1910402 On the other hand , inhibition of expression by small interfering RNA ( siRNA ) *resulted* in an induced response to DHT of [androgen-receptor] target genes such as PSA , KLK4 , NKX3.1 , TMPRSS2 , SLC16A6 and VEGF . Positive_regulation ARAF EPHB2 12364324 1019153 GLP1 stimulated activation of is blocked by inhibitors of MEK , but GLP1 does not *induce* the activation of [A-Raf] , B-Raf , C-Raf , or Ras . Positive_regulation ARC EPHB2 18798281 2021031 Surprisingly , BAPTA-AM did not block ERK activation , indicating that [ Ca ( 2+ ) ] ( i ) and Ras-Raf-MAPK are not coupled , and the activation of alone is not *sufficient* to up-regulate [Arc] transcription . Positive_regulation ARC EPHB2 21559295 2429477 Convulsant doses of a dopamine D1 receptor agonist result in *dependent* increases in Zif268 and [Arc/Arg3.1] expression in mouse dentate gyrus . Positive_regulation ARC MSX1 10879654 709042 In a selective type of tooth agenesis , an G -- > C transversion *results* in a missense mutation [Arg31Pro] . Positive_regulation AREG AGR2 21454516 2427725 The present study shows that *induces* expression of [amphiregulin (AREG)] , a growth promoting EGFR ligand . Positive_regulation AREG AGR2 21454516 2427728 Additional experiments demonstrate that *induction* of [AREG] is mediated by activation of the Hippo signaling pathway co-activator , YAP1 . Positive_regulation AREG AGR2 22184114 2549419 Using two different cell lines in which *induces* expression of either the EGFR ligand [amphiregulin] or the transcription factor CDX2 , only the highly conserved wild-type carboxyl-terminal KTEL motif results in the appropriate outcome . Positive_regulation AREG HBEGF 10985499 732357 Furthermore , activation of the EGF system in these cells by stimulation with or EGF in mitogenic doses *causes* a selective increase in the expression of [amphiregulin] and HB-EGF mRNA ( more than 15-fold and 25-fold , respectively ) , whereas there is no increase in the expression of mRNA for the other growth factors or receptors . Positive_regulation AREG HBEGF 21482691 2434550 Moreover , and CXCL12 together *enhanced* TNFa converting enzyme ( TACE ) -dependent [amphiregulin] shedding from NUGC4 cells . Positive_regulation AREG IL1B 15474551 1319083 Gastrin and *stimulated* the secretion of heparin binding epidermal growth factor and [amphiregulin] but not transforming growth factor-alpha from parietal cells . Positive_regulation AREG TNF 20161853 2179374 Furthermore , *induced* secretion of IL-6 , IL-8 , EGF , HGF , TGF-alpha , epiregulin , and [amphiregulin] were compared among these keratinocytes . Positive_regulation AREG TNF 20161853 2179378 The significant induction of *increased* IL-6 , IL-8 , EGF , HGF , TGF-alpha , epiregulin , and [amphiregulin] , but the increase in these cytokines and growth factors were not different among normal skin , uninvolved , and involved psoriasis . Positive_regulation AREGB IL1B 15685553 1370978 [Amphiregulin] expression is *induced* in isolated hepatocytes by and prostaglandin E ( 2 ) , but not by hepatocyte growth factor , interleukin 6 , or tumor necrosis factor alpha . Positive_regulation ARF1 EFNB1 17567680 1763206 In support of this hypothesis , activation of *increased* GTP bound [Arf1] , and the secretion of MMP-8 was reduced by expression of a dominant negative mutant of Arf1 . Positive_regulation ARF1 EPHB2 21660463 2489855 Totally , the functional *roles* of and p21 for [ARF] in p53 independent tumor suppression were demonstrated . Positive_regulation ARF1 IL1B 17400889 1760671 renal *increased* nearly 2-fold in cisplatin induced [ARF] and was reduced in the caspase-1 ( -/- ) mice . Positive_regulation ARF1 IL1B 17400889 1760677 However , inhibition of , IL-18 , and IL-6 or neutrophil infiltration in the kidney is not *sufficient* to prevent cisplatin induced [ARF] . Positive_regulation ARF1 TNF 14764737 1207404 We therefore hypothesized that LPS induced [acute renal failure (ARF)] *requires* systemic release triggered by LPS acting on extrarenal TLR4 . Positive_regulation ARF1 TNF 16467041 1523425 These findings suggest that the *role* of in [ARF] may be in linkage disequilibrium with some other severity genes not yet genetically determined . Positive_regulation ARF3 EPHB2 21660463 2489857 Totally , the functional *roles* of and p21 for [ARF] in p53 independent tumor suppression were demonstrated . Positive_regulation ARF3 IL1B 17400889 1760672 renal *increased* nearly 2-fold in cisplatin induced [ARF] and was reduced in the caspase-1 ( -/- ) mice . Positive_regulation ARF3 IL1B 17400889 1760680 However , inhibition of , IL-18 , and IL-6 or neutrophil infiltration in the kidney is not *sufficient* to prevent cisplatin induced [ARF] . Positive_regulation ARF3 TNF 14764737 1207405 We therefore hypothesized that LPS induced [acute renal failure (ARF)] *requires* systemic release triggered by LPS acting on extrarenal TLR4 . Positive_regulation ARF3 TNF 16467041 1523426 These findings suggest that the *role* of in [ARF] may be in linkage disequilibrium with some other severity genes not yet genetically determined . Positive_regulation ARF4 EPHB2 21660463 2489859 Totally , the functional *roles* of and p21 for [ARF] in p53 independent tumor suppression were demonstrated . Positive_regulation ARF4 IL1B 17400889 1760673 renal *increased* nearly 2-fold in cisplatin induced [ARF] and was reduced in the caspase-1 ( -/- ) mice . Positive_regulation ARF4 IL1B 17400889 1760683 However , inhibition of , IL-18 , and IL-6 or neutrophil infiltration in the kidney is not *sufficient* to prevent cisplatin induced [ARF] . Positive_regulation ARF4 TNF 14764737 1207406 We therefore hypothesized that LPS induced [acute renal failure (ARF)] *requires* systemic release triggered by LPS acting on extrarenal TLR4 . Positive_regulation ARF4 TNF 16467041 1523427 These findings suggest that the *role* of in [ARF] may be in linkage disequilibrium with some other severity genes not yet genetically determined . Positive_regulation ARF5 EPHB2 21660463 2489861 Totally , the functional *roles* of and p21 for [ARF] in p53 independent tumor suppression were demonstrated . Positive_regulation ARF5 IL1B 17400889 1760674 renal *increased* nearly 2-fold in cisplatin induced [ARF] and was reduced in the caspase-1 ( -/- ) mice . Positive_regulation ARF5 IL1B 17400889 1760686 However , inhibition of , IL-18 , and IL-6 or neutrophil infiltration in the kidney is not *sufficient* to prevent cisplatin induced [ARF] . Positive_regulation ARF5 TNF 14764737 1207407 We therefore hypothesized that LPS induced [acute renal failure (ARF)] *requires* systemic release triggered by LPS acting on extrarenal TLR4 . Positive_regulation ARF5 TNF 16467041 1523428 These findings suggest that the *role* of in [ARF] may be in linkage disequilibrium with some other severity genes not yet genetically determined . Positive_regulation ARF6 ARL4D 17804820 1810170 Consistent with a known action of cytohesin-2/ARNO , ( Q80L ) *increased* GTP bound [ARF6] and induced disassembly of actin stress fibers . Positive_regulation ARF6 EPHB2 19247477 2040742 A-RAF induced activation is *required* for this step by activating [ARF6] , as A-RAF depletion or inhibition of the A-RAF controlled MEK-ERK cascade blocks recycling . Positive_regulation ARF6 EPHB2 21660463 2489863 Totally , the functional *roles* of and p21 for [ARF] in p53 independent tumor suppression were demonstrated . Positive_regulation ARF6 IL1B 17400889 1760675 renal *increased* nearly 2-fold in cisplatin induced [ARF] and was reduced in the caspase-1 ( -/- ) mice . Positive_regulation ARF6 IL1B 17400889 1760689 However , inhibition of , IL-18 , and IL-6 or neutrophil infiltration in the kidney is not *sufficient* to prevent cisplatin induced [ARF] . Positive_regulation ARF6 MAP2K6 19642173 2150010 This stimulation was caused by increased transcription of [ARF6] and by *activation* of the signal regulated kinase 1 and 2 ( ERK1/2 ) and PI3K signaling pathways . Positive_regulation ARF6 TNF 14764737 1207408 We therefore hypothesized that LPS induced [acute renal failure (ARF)] *requires* systemic release triggered by LPS acting on extrarenal TLR4 . Positive_regulation ARF6 TNF 16467041 1523429 These findings suggest that the *role* of in [ARF] may be in linkage disequilibrium with some other severity genes not yet genetically determined . Positive_regulation ARG1 EPHB2 11494128 846127 Activated *causes* tyrosine phosphorylation of Abl and [Arg] , and vice versa . Positive_regulation ARG1 EPHB2 21559295 2429479 Convulsant doses of a dopamine D1 receptor agonist result in *dependent* increases in Zif268 and [Arc/Arg3.1] expression in mouse dentate gyrus . Positive_regulation ARG1 IL1B 7834189 285977 *Up-regulation* of [ 3H ] [-des-Arg10-kallidin] binding to the bradykinin B1 receptor by in isolated smooth muscle cells : correlation with B1 agonist induced PGI2 production . Positive_regulation ARG1 TLR7 18978793 1989525 In contrast to diseases dominated by T helper type 2 responses in which Arg1 expression is greatly increased by interleukin 4 and 13 signaling through the transcription factor STAT6 , mediated [Arg1] *induction* was independent of the STAT6 pathway . Positive_regulation ARG1 TNF 15836764 1397776 Actinomycin D abolished and dexamethasone concentration-dependently suppressed the *induced* enhancement of the [des-Arg9-bradykinin] and bradykinin responses . Positive_regulation ARG1 TNF 1830780 163654 Expression of [arginase] by mouse myeloid leukemic cell differentiation in vitro *induced* with . Positive_regulation ARG1 TNF 22069588 2362469 Both [Arg-] and Lys-gingipain preparations *induced* the secretion of and IL-8 by macrophages . Positive_regulation ARG2 EPHB2 11494128 846128 Activated *causes* tyrosine phosphorylation of Abl and [Arg] , and vice versa . Positive_regulation ARG2 EPHB2 21559295 2429481 Convulsant doses of a dopamine D1 receptor agonist result in *dependent* increases in Zif268 and [Arc/Arg3.1] expression in mouse dentate gyrus . Positive_regulation ARG2 IL1B 7834189 285978 *Up-regulation* of [ 3H ] [-des-Arg10-kallidin] binding to the bradykinin B1 receptor by in isolated smooth muscle cells : correlation with B1 agonist induced PGI2 production . Positive_regulation ARG2 STK39 18621907 1966301 The inhibitors PP2 ( 10 microM ) and herbimycin A ( 10 microM ) also *prevented* the L/T induced expression of both [arginase II] and iNOS mRNA in bPAEC . Positive_regulation ARG2 STK39 18621907 1966346 Together , the data demonstrate a central *role* of in the upregulation of both [arginase II] and iNOS in bPAEC in response to L/T treatment . Positive_regulation ARG2 TNF 15836764 1397777 Actinomycin D abolished and dexamethasone concentration-dependently suppressed the *induced* enhancement of the [des-Arg9-bradykinin] and bradykinin responses . Positive_regulation ARG2 TNF 1830780 163655 Expression of [arginase] by mouse myeloid leukemic cell differentiation in vitro *induced* with . Positive_regulation ARG2 TNF 22069588 2362471 Both [Arg-] and Lys-gingipain preparations *induced* the secretion of and IL-8 by macrophages . Positive_regulation ARHGAP4 NEDD9 12189134 992645 Digestion with specific phosphatases indicated that the [p115HEF1] *resulted* from serine/threonine phosphorylation of . Positive_regulation ARHGEF1 F2R 24025335 2857094 Inhibition or depletion of also *blocked* thrombin induced activation of Pyk2 , Gab1 , [p115 RhoGEF] , Rac1 , RhoA , and Pak2 , resulting in diminished THP-1 cell F-actin cytoskeletal remodeling and migration . Positive_regulation ARHGEF1 F2R 24025335 2857098 These novel observations reveal that thrombin induces monocyte/macrophage migration via *dependent* Pyk2 mediated Gab1 and [p115 RhoGEF] interactions , leading to Rac1- and RhoA targeted Pak2 activation . Positive_regulation ARHGEF15 EPHB2 21029865 2338762 *mediated* degradation of the RhoA GEF [Ephexin5] relieves a developmental brake on excitatory synapse formation . Positive_regulation ARHGEF2 CCND1 19730435 2139508 [GEF-H1] and ZONAB are required for expression of endogenous cyclin D1 , a crucial RhoA signalling target gene , and GEF-H1 stimulated promoter activity *requires* ZONAB . Positive_regulation ARHGEF2 EPHB2 20237148 2259886 This conclusion is based on our findings that 1 ) depolarization activated GEF-H1 but not p115RhoGEF , 2 ) short interfering RNA mediated GEF-H1 silencing eliminated the activation of the Rho pathway , and 3 ) inhibition *prevented* the activation of [GEF-H1] . Positive_regulation ARHGEF2 EPHB2 21212278 2408306 We have previously shown that *mediated* stimulation of the RhoA GDP/GTP exchange factor [GEF-H1/Lfc] is critical for TNF-a induced RhoA stimulation . Positive_regulation ARHGEF2 EPHB2 21212278 2408312 EGF treatment mimicked the effects of TNF-a , as it elicited potent , *dependent* [GEF-H1] and RhoA activation . Positive_regulation ARHGEF2 EPHB2 21572419 2435568 Our results reveal that LARG is activated by the Src family tyrosine kinase Fyn , whereas [GEF-H1] catalytic activity is *enhanced* by downstream of a signalling cascade that includes FAK and Ras . Positive_regulation ARHGEF2 EPHB2 24356971 2911141 In summary , we have identified complement induced *dependent* [GEF-H1] activation as the upstream mechanism of RhoA stimulation , and this pathway has a protective role against cell death . Positive_regulation ARHGEF25 RGS2 24299002 2899072 Furthermore , we were able to detect activation dependent FRET between RGS2 and p63RhoGEF and observed a reduced [p63RhoGEF] mediated downstream signalling in the *presence* of . Positive_regulation ARHGEF7 GPR115 10400698 628492 We have analyzed in Chinese hamster ovary cells the upstream mediators by which the , gastrin/CCKB , *activates* the extracellular regulated kinases ( ERKs ) and [p85/p110-phosphatidylinositol] 3-kinase ( PI 3-kinase ) pathways . Positive_regulation ARHGEF7 GPR132 10400698 628481 We have analyzed in Chinese hamster ovary cells the upstream mediators by which the , gastrin/CCKB , *activates* the extracellular regulated kinases ( ERKs ) and [p85/p110-phosphatidylinositol] 3-kinase ( PI 3-kinase ) pathways . Positive_regulation ARHGEF7 GPR87 10400698 628561 We have analyzed in Chinese hamster ovary cells the upstream mediators by which the , gastrin/CCKB , *activates* the extracellular regulated kinases ( ERKs ) and [p85/p110-phosphatidylinositol] 3-kinase ( PI 3-kinase ) pathways . Positive_regulation ARHGEF7 NES 21383062 2420873 These studies show that p110ß NLS and p85ß *regulate* [p85ß/p110ß] nuclear localization , supporting the idea that nuclear , but not cytoplasmic , p110ß controls cell survival . Positive_regulation ARID1A IL1B 16847181 1588117 The messenger RNA expressions of [LARC] ( liver and activation regulated chemokine ) , GMCSF ( granulocyte-macrophage colony stimulating factor ) , epiregulin , ICAM1 ( intercellular adhesion molecule 1 ) , and TGFA ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation ARID1A MAP2K6 15208625 1268009 The SWI-SNF subunit [BAF60] could be phosphorylated by p38 alpha-beta in vitro , and forced activation of p38 alpha/beta in myoblasts by expression of a constitutively active ( refs. 5,6,7 ) *promoted* unscheduled SWI-SNF recruitment to the myogenin promoter . Positive_regulation ARID1B EPHB2 12824291 1113619 These results indicate that *dependent* [R-Smad] linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells . Positive_regulation ARID4B CAPN8 17986223 1850707 Interestingly , [SAP] did not *induce* caspase and activation , suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways . Positive_regulation ARID4B TNF 10788429 688664 Acute phorbol 12-myristate 13-acetate pretreatment also inhibited *stimulated* [SAP] kinase activity , while chronic pretreatment reversed the effects of UTP . Positive_regulation ARNTL TNF 23496259 2803948 *enhanced* the mRNA expression of [Bmal1] and Cry1 but did not affect that of Clock , Per1 , or Cry2 . Positive_regulation ARRB1 EPHB2 10347142 616730 Inhibition of activity by a dominant negative MEK1 mutant significantly *attenuates* [beta-arrestin1] phosphorylation , thereby increasing the concentration of dephosphorylated beta-arrestin1 . Positive_regulation ARRB1 EPHB2 18777088 2020495 An activated GPCR undergoes down regulation via a known mechanism involving ERK , GRK2 , [beta-arrestin1] : activity *increases* ; Positive_regulation ARRB1 EPHB2 19153083 2060969 A cell-permeable , 25-mer N-stearoylated betaarrestin1 peptide that encompassed the N-domain MEK1 binding site blocked betaarrestin1/MEK1 association in HEK cells and recapitulated the altered phenotype seen with the D26A/D29A-betaarrestin1 in compromising the *dependent* phosphorylation of [betaarrestin1] . Positive_regulation ARRB1 TNF 17664271 1793913 We found that [beta-arrestin-1] is associated with TRAF2 ( TNF receptor associated factor 2 ) , an adaptor protein of TNF receptors , and that acutely *stimulates* tyrosine phosphorylation of G alpha ( q/11 ) with an increase in G alpha ( q/11 ) activity . Positive_regulation ARSA ABCC1 16944117 1627496 From these in-vitro experiments one can conclude that intestinal secretion of [5-ASA] is apparently not *mediated* by P-gp or . Positive_regulation ARSA ANPEP 22066831 2557334 remarkably and continuously *enhanced* intracellular [AsA] and promoted type 1 collagen synthesis and mRNA expression . Positive_regulation ARSA ARSD 17030823 1634467 Interaction with *increases* the affinity of [ArsA] for arsenite , thus increasing its ATPase activity at lower concentrations of arsenite and enhancing the rate of arsenite extrusion . Positive_regulation ARSA ARSD 21188475 2425301 transfers As(III) to ArsA and *increases* the affinity of [ArsA] for As(III) , allowing resistance to environmental concentrations of arsenic . Positive_regulation ARSA AVP 6089589 41303 Three-day incubations with dDAVP or AVP apparently induced cyclooxygenase activity since PGE2 synthesis increased in response to arachidonic acid and recovery of cyclooxygenase activity after [ASA] was *enhanced* by dDAVP or . Positive_regulation ARSA CASP3 18678619 1973301 [ASA] and NaS at 1 mM did not *induce* PARP cleavage or and at 5 mM , ASA but not NaS increased apoptosis . Positive_regulation ARSA CDKN1A 24692690 2931510 At higher concentrations , [AsA] *induced* apoptosis of osteosarcoma cells , possibly with the involvement of . Positive_regulation ARSA CISH 21134595 2366337 cis-Pt ( II ) -like CD spectral change and crosslink formation in calf thymus DNA were also observed during this DNA oxidation , suggesting cis-Pt ( IV ) reduction by [AsA] and DNA conformational change *induced* by the newly formed ( II ) binding to DNA . Positive_regulation ARSA COPS5 23424245 2760023 Together , our data reveal a regulatory *role* of in light-dark regulation of [AsA] synthesis . Positive_regulation ARSA GAL 19453508 2090780 The [AsA] concentration *increased* markedly with L-galactono-1,4-lactone or , but d-galacturonate and L-gulono-1,4-lactone failed to increase AsA , indicating dominance of the Gal pathway and potent AsA biosynthetic capabilities in immature peach flesh . Positive_regulation ARSA GSTT2 9729437 530148 Gastric levels were induced by ibuprofen ( 1.6x ) and indomethacin ( 1.5x ) , and colonic levels were *induced* by [ASA] ( 1.7x ) . Positive_regulation ARSA HBA1 16698007 1604755 [ASA] *induces* a modest , not clinically relevant , increase in levels with one of the methods . Positive_regulation ARSA IFNG 8931897 397887 In addition , significantly *increases* the antibacterial activity of [ASA] and ibuprofen . Positive_regulation ARSA MAST1 11064108 746852 W/W ( v ) mice were sensitized by oral administration of 0.1 and 1.0 mg ovalbumin ( OVA ) by gavage every day for 9 weeks , and [active systemic anaphylaxis (ASA)] was *induced* by intraperitoneal injection of OVA . Positive_regulation ARSA MAST2 11064108 746853 W/W ( v ) mice were sensitized by oral administration of 0.1 and 1.0 mg ovalbumin ( OVA ) by gavage every day for 9 weeks , and [active systemic anaphylaxis (ASA)] was *induced* by intraperitoneal injection of OVA . Positive_regulation ARSA MAST3 11064108 746854 W/W ( v ) mice were sensitized by oral administration of 0.1 and 1.0 mg ovalbumin ( OVA ) by gavage every day for 9 weeks , and [active systemic anaphylaxis (ASA)] was *induced* by intraperitoneal injection of OVA . Positive_regulation ARSA MAST4 11064108 746855 W/W ( v ) mice were sensitized by oral administration of 0.1 and 1.0 mg ovalbumin ( OVA ) by gavage every day for 9 weeks , and [active systemic anaphylaxis (ASA)] was *induced* by intraperitoneal injection of OVA . Positive_regulation ARSA MPI 18755683 1975328 Moreover , a reduction of expression through RNA interference *resulted* in a substantial decrease in the total [AsA] content of leaves of knockdown PMI1 plants , whereas the complete inhibition of PMI2 expression did not affect the total AsA levels in leaves of knock-out PMI2 plants . Positive_regulation ARSA MPI 24157701 2875328 Therefore , the high expression levels of , GME , and GGP and the low expression level of AAO *contributed* to the high [AsA] accumulation in non heading Chinese cabbage . Positive_regulation ARSA NOS2 17218764 1664119 We conclude that [ASA-VitC] in comparison with ASA induces less gastric mucosal damage and this protective effect may be *due* to its inhibitory effect on expression . Positive_regulation ARSA NQO1 23129230 2703890 In the *presence* of the colon-specific enzyme ( orange ) , [5-ASA] and sulfapyridine are efficiently released . Positive_regulation ARSA PDS5B 21299644 2388493 Transfer of *increases* the affinity of [ArsA] for As(III) , allowing resistance to environmental arsenic concentrations . Positive_regulation ARSA PGP 16944117 1627497 From these in-vitro experiments one can conclude that intestinal secretion of [5-ASA] is apparently not *mediated* by or MRP2 . Positive_regulation ARSA PTGS1 14633677 1170787 Interestingly , [NO-ASA] *induced* COX-2 expression , although it had no effect on . Positive_regulation ARSA PTGS2 14633677 1170788 Interestingly , [NO-ASA] *induced* expression , although it had no effect on COX-1 . Positive_regulation ARSA PTGS2 16804302 1591043 [ASA] *induced* both damage and expression in the stomach when given p.o. but not s.c. , despite decreasing the PGE ( 2 ) level similarly via either route of administration . Positive_regulation ARSA PTGS2 19576865 2142563 expression was *induced* by [p-NO-ASA] , protein kinase C inhibitors reversed this induction . Positive_regulation ARSA SLPI 11598899 870539 [AsA] *induced* activity and protein in cells in conventional monolayer culture . Positive_regulation ARSA SOD1 22126037 2514774 In treatments 30 , 50 , and 100 micromol x L ( -1 ) of CuSO4 , the leaf H2O2 , OH. , and MDA contents and and EST activities increased , and GSH and [AsA] contents *increased* significantly . Positive_regulation ARSA SOD2 22126037 2514775 In treatments 30 , 50 , and 100 micromol x L ( -1 ) of CuSO4 , the leaf H2O2 , OH. , and MDA contents and and EST activities increased , and GSH and [AsA] contents *increased* significantly . Positive_regulation ARSA SOD3 22126037 2514776 In treatments 30 , 50 , and 100 micromol x L ( -1 ) of CuSO4 , the leaf H2O2 , OH. , and MDA contents and and EST activities increased , and GSH and [AsA] contents *increased* significantly . Positive_regulation ARSA TJP1 22917627 2683145 We measured whether [ASA] *induced* the increase of differentiated Caco-2 permeability , the decrease of tight junction protein expression , the production of reactive oxygen species ( ROS ) , and the expression of ROS modified protein . Positive_regulation ARSA TNF 10593965 572936 In summary , [5-ASA] inhibits *stimulated* IKKalpha kinase activity toward IkappaBalpha in intestinal epithelial cells . Positive_regulation ARSD LBP 7681085 214215 Studies with human CD14 expressing transfectants of the murine B cell line 70Z/3 also revealed *dependent* cross linking of [125I-ASD-LPS] to CD14 . Positive_regulation ARSE CAPN8 11449356 836536 Etoposide induced expression of the cleaved , proteolytically active form of caspase 3 , and [DEVD-ase] activity , detected prior to nuclear damage , were blocked in the *presence* of inhibitors . Positive_regulation ARSE TNFSF10 16581346 1543708 As disruption of mitochondrial transmembrane potential ( DeltaPsim ) , Leu-Glu-His-Asp [ase] ( IETD ase ) activity , and the appearance of hypodiploid DNA + cells were markedly suppressed in IFN-gamma treated FLS in *response* to , IFN-gamma induced suppression was supposed to achieve at upstream of caspase-8 . Positive_regulation ARSG CYP1A1 10484072 643920 The activity *increased* continuously up to 72 hr , where ASG showed an induction efficiency in the same range as for the positive control ( 1 microM ICZ ) after 24 hr , whereas the CYP1A1 protein level , measured by Western blot analysis , was maximally induced after 24 hr . [ASG] significantly inhibited CYP1A1 activity in whole cells at concentrations above 1 microM . Positive_regulation ARSH MUC16 10702361 672673 Residual oil fly [ash] *induces* cytotoxicity and secretion by guinea pig tracheal epithelial cells via an oxidant mediated mechanism . Positive_regulation ARSH TNF 10094246 601101 Coal fly [ash-] and copper smelter dust *induced* modulation of ex vivo production of by murine macrophages : effects of metals and overload . Positive_regulation ART1 FAS 10094623 557572 Alignment studies predict that the amino-terminus of exoenzyme S has limited primary amino acid homology with the YopE cytotoxin of Yersinia , while biochemical studies have localized the *dependent* [ADP-ribosyltransferase] activity to the carboxyl-terminus . Positive_regulation ART1 FAS 10231494 611350 Intracellular expression of the amino-terminal domain of ExoS elicits the disruption of actin , while expression of the carboxyl-terminal domain of ExoS possesses *dependent* [ADP-ribosyltransferase] activity and is cytotoxic to eukaryotic cells . Positive_regulation ART1 FAS 11821389 922573 Although the [ADP-ribosyltransferase] activity of ExoS is *dependent* upon , a 14-3-3 family protein , factor activating ExoS (FAS) had no influence on the activity of the GAP domain of ExoS ( ExoS-GAP ) . Positive_regulation ART1 FAS 8977313 403354 IFN-alpha2 did not alter the Apo-1/Fas induced activity of Mitogen activated protein kinase (MAPK) 1 and did not inhibit the *mediated* proteolytic cleavage of [ADP-ribosyltransferase] , a substrate of Interleukin-beta1 converting enzyme ( ICE ) and homologues . Positive_regulation ART1 TNF 1280112 203064 did not *lead* to an increase in [ADP-ribosyltransferase] activity nor to a change in the pattern of ADP ribosylated proteins . Positive_regulation ART3 FAS 10094623 557573 Alignment studies predict that the amino-terminus of exoenzyme S has limited primary amino acid homology with the YopE cytotoxin of Yersinia , while biochemical studies have localized the *dependent* [ADP-ribosyltransferase] activity to the carboxyl-terminus . Positive_regulation ART3 FAS 10231494 611351 Intracellular expression of the amino-terminal domain of ExoS elicits the disruption of actin , while expression of the carboxyl-terminal domain of ExoS possesses *dependent* [ADP-ribosyltransferase] activity and is cytotoxic to eukaryotic cells . Positive_regulation ART3 FAS 11821389 922574 Although the [ADP-ribosyltransferase] activity of ExoS is *dependent* upon , a 14-3-3 family protein , factor activating ExoS (FAS) had no influence on the activity of the GAP domain of ExoS ( ExoS-GAP ) . Positive_regulation ART3 FAS 8977313 403355 IFN-alpha2 did not alter the Apo-1/Fas induced activity of Mitogen activated protein kinase (MAPK) 1 and did not inhibit the *mediated* proteolytic cleavage of [ADP-ribosyltransferase] , a substrate of Interleukin-beta1 converting enzyme ( ICE ) and homologues . Positive_regulation ART3 TNF 1280112 203065 did not *lead* to an increase in [ADP-ribosyltransferase] activity nor to a change in the pattern of ADP ribosylated proteins . Positive_regulation ART4 FAS 10094623 557574 Alignment studies predict that the amino-terminus of exoenzyme S has limited primary amino acid homology with the YopE cytotoxin of Yersinia , while biochemical studies have localized the *dependent* [ADP-ribosyltransferase] activity to the carboxyl-terminus . Positive_regulation ART4 FAS 10231494 611352 Intracellular expression of the amino-terminal domain of ExoS elicits the disruption of actin , while expression of the carboxyl-terminal domain of ExoS possesses *dependent* [ADP-ribosyltransferase] activity and is cytotoxic to eukaryotic cells . Positive_regulation ART4 FAS 11821389 922575 Although the [ADP-ribosyltransferase] activity of ExoS is *dependent* upon , a 14-3-3 family protein , factor activating ExoS (FAS) had no influence on the activity of the GAP domain of ExoS ( ExoS-GAP ) . Positive_regulation ART4 FAS 8977313 403356 IFN-alpha2 did not alter the Apo-1/Fas induced activity of Mitogen activated protein kinase (MAPK) 1 and did not inhibit the *mediated* proteolytic cleavage of [ADP-ribosyltransferase] , a substrate of Interleukin-beta1 converting enzyme ( ICE ) and homologues . Positive_regulation ART4 TNF 1280112 203066 did not *lead* to an increase in [ADP-ribosyltransferase] activity nor to a change in the pattern of ADP ribosylated proteins . Positive_regulation ART5 FAS 10094623 557571 Alignment studies predict that the amino-terminus of exoenzyme S has limited primary amino acid homology with the YopE cytotoxin of Yersinia , while biochemical studies have localized the *dependent* [ADP-ribosyltransferase] activity to the carboxyl-terminus . Positive_regulation ART5 FAS 10231494 611349 Intracellular expression of the amino-terminal domain of ExoS elicits the disruption of actin , while expression of the carboxyl-terminal domain of ExoS possesses *dependent* [ADP-ribosyltransferase] activity and is cytotoxic to eukaryotic cells . Positive_regulation ART5 FAS 11821389 922572 Although the [ADP-ribosyltransferase] activity of ExoS is *dependent* upon , a 14-3-3 family protein , factor activating ExoS (FAS) had no influence on the activity of the GAP domain of ExoS ( ExoS-GAP ) . Positive_regulation ART5 FAS 8977313 403340 IFN-alpha2 did not alter the Apo-1/Fas induced activity of Mitogen activated protein kinase (MAPK) 1 and did not inhibit the *mediated* proteolytic cleavage of [ADP-ribosyltransferase] , a substrate of Interleukin-beta1 converting enzyme ( ICE ) and homologues . Positive_regulation ART5 TNF 1280112 203063 did not *lead* to an increase in [ADP-ribosyltransferase] activity nor to a change in the pattern of ADP ribosylated proteins . Positive_regulation ASAH1 SPHK1 23732709 2796900 [Acid ceramidase] *induces* receptor 2-mediated activation of oncogenic Akt signaling . Positive_regulation ASAH2 IL1B 11457826 860138 Interestingly , *stimulated* [neutral ceramidase] activation was not reduced in mesangial cells isolated from mice deficient in MAPK activated protein kinase-2 , which is a downstream substrate of p38 MAPK , thus suggesting that the p38 MAPK mediated induction of neutral ceramidase occurs independently of the MAPK activated protein kinase-2 pathway . Positive_regulation ASAH2 IL1B 9228043 443447 IL-1beta *increases* both acid and [neutral ceramidase] activities , which appear to be regulated by tyrosine phosphorylation because pretreatment of hepatocytes with sodium vanadate increases ( and 25 microM genistein reduces ) the basal and stimulated ceramidase activities . Positive_regulation ASAH2 TNF 19696154 2151166 The TR of CD4+ and CD8+ from MS patients across *activated* [hCMEC/D3] were also significantly higher than that observed in HI . Positive_regulation ASB4 TNF 21506136 2439209 Further investigation indicated that nuclear factor kappa B ( NF-?B ) is the responsible transcription factor involved in the *induced* upregulation of [ASB4] , placing ASB4 downstream of NF-?B in the TNF-a signalling cascade and identifying it as a potential regulator for TNF-a 's numerous functions associated with inflammation , angiogenesis and apoptosis . Positive_regulation ASCL1 EPHB2 11306509 804220 Active Notch proteins also led to dramatic reduction in [hASH1] expression , as well as marked *activation* of phosphorylated extracellular signal regulated kinase ( ) 1 and ERK2 , findings that have been shown to be associated with cell cycle arrest in SCLC cells . Positive_regulation ASIC3 EPHB2 17696763 1829730 Expression of [acid sensing ion channel 3 (ASIC3)] in nucleus pulposus cells of the intervertebral disc is *regulated* by p75NTR and signaling . Positive_regulation ASIC3 EPHB2 17696763 1829739 Moreover , inhibition of activity by dominant negative-mitogen activated protein kinase kinase ( DN-MEK ) *resulted* in a dose dependent suppression of [ASIC3] basal promoter activity , whereas overexpression of constitutively active MEK1 caused an increase in ASIC3 promoter activity . Positive_regulation ASIP FAS 9637525 513854 Indeed , ligation of both and BCR *resulted* in cleavage of the IL-1beta converting enzyme/Ced-3-like protease caspase 3 and its substrates [Ac-Asp-Glu-Val-Asp-aldehyde] and poly ( ADP-ribose ) polymerase . Positive_regulation ASIP RGS16 9753466 533945 In a single-turnover assay , maximally *stimulated* GTPase activity of Gs alpha [Asp229Ser] by approximately 5-fold with an EC50 value of 7.5 microM . Positive_regulation ASS1 IL1B 15820746 1393732 In the present study , using Caco-2 cells , a human enterocyte line , we demonstrate that rapidly *induces* the expression of the [ASS] gene at a transcriptional level through NF-kappaB activation . Positive_regulation ASS1 IL1B 17892496 1802591 We previously demonstrated that the expression of the [argininosuccinate synthetase (ASS)] gene , a key step in nitric oxide production , is *stimulated* either by [ Brasse-Lagnel et al. ( 2005 ) Biochimie 87 , 403-9 ] or by glutamine in Caco-2 cells [ Brasse-Lagnel et al. ( 2003 ) J. Biol. Chem. 278 , 52504-10 ] , through the activation of transcription factors nuclear factor-kappaB and Sp1 , respectively . Positive_regulation ASS1 TNF 17354225 1727242 Here , we show that also *induces* expression of arate limiting enzyme in arginine synthesis , [argininosuccinate synthetase (AS)] , thereby linking inflammation with several arginine dependent metabolic pathways , implicated in accelerated carcinogenesis and tumour progression . Positive_regulation ATD PLAT 15448144 1334952 Furthermore , point mutation analyses show that arginine 260 is necessary for both *induced* cleavage of the [ATD] of NR1 and tPA induced potentiation of NMDA receptor signaling . Positive_regulation ATF1 CCND1 11375399 834913 [Activating transcription factor] 3 *induces* DNA synthesis and expression of in hepatocytes . Positive_regulation ATF1 CTGF 11732999 885299 These inhibitors of MAPKK and MAPK suppressed phosphorylation of ets-like gene-1 (Elk-1) and nuclear [activating transcription factor-2] ( Atf-2 ) *induced* by in a dose dependent manner , respectively . Positive_regulation ATF1 EPHB2 11682632 874325 activation by the PKA pathway was not *required* for [CREB/ATF-1] phosphorylation but rather was necessary for CREB dependent up-regulation of C/EBPs expression . Positive_regulation ATF1 EPHB2 17082637 1643370 inhibition not only *blocked* phosphorylation of Elk1 , CREB , and [ATF1] , which constitutively bind to the FRA-1 promoter , but also suppressed the recruitment of c-Jun to the promoter . Positive_regulation ATF1 MMP28 21505267 2448806 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and activating transcription factor 1 ( [ATF1] ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or . Positive_regulation ATF1 MMP7 21505267 2448822 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and activating transcription factor 1 ( [ATF1] ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or . Positive_regulation ATF1 TLR7 18802113 1964856 IFN-gamma strongly enhanced *induced* expression of the transcriptional repressor [activating transcription factor] ( ATF-3 ) in a STAT1 dependent manner , which correlated with recruitment of ATF-3 to the endogenous MMP-1 promoter as detected by chromatin immunoprecipitation assays . Positive_regulation ATF1 TLR7 20351107 2260721 Interestingly , c-Src regulated *stimulated* induction of [activating transcription factor] 3 ( ATF3 ) , a transcriptional repressor . Positive_regulation ATF1 TLR7 24470589 2927604 Expression of the [activating transcription factor] 3 ( ATF3 ) gene is *induced* by signaling . Positive_regulation ATF1 TNF 11108246 756737 In addition , *induced* [activating transcription factor-1] phosphorylation is extensively decreased by SB203580 . Positive_regulation ATF1 TNF 17082637 1643377 Our findings collectively indicate that ERK signaling plays key roles in both Elk1 , CREB , and [ATF-1] activation and the subsequent recruitment of c-Jun to the FRA-1 promoter in *response* to in pulmonary epithelial cells . Positive_regulation ATF1 TNF 22198289 2558692 In addition , IL-1ß and *induced* the phosphorylation of [activating transcription factor-2] ( ATF-2 ) , but not c-Jun . Positive_regulation ATF1 TNF 24038085 2851647 Neutrophil stimulation with LPS or *led* to the phosphorylation , DNA binding activity , and chemokine promoter association of CREB1 and [activating transcription factor-1] . Positive_regulation ATF2 CCND1 11375399 834914 [Activating transcription factor] 3 *induces* DNA synthesis and expression of in hepatocytes . Positive_regulation ATF2 CTGF 11732999 885313 These inhibitors of MAPKK and MAPK suppressed phosphorylation of ets-like gene-1 (Elk-1) and nuclear [activating transcription factor-2] ( Atf-2 ) *induced* by in a dose dependent manner , respectively . Positive_regulation ATF2 EPHB2 22865631 2666111 Gallic acid treatment repressed *mediated* c-Fos phosphorylation and JNK1 mediated [ATF-2] phosphorylation . Positive_regulation ATF2 IL1B 10640438 577522 The transcription factors , c-Jun and ATF2 , are phosphorylated by the MAPKs and are implicated in the upregulation of c-Jun . and TNF alpha *stimulated* the phosphorylation of c-Jun and [ATF2] . Positive_regulation ATF2 IL1B 16497991 1548951 Western blot analysis using phospho-specific antibodies showed that *stimulated* p38 MAP kinase and phosphorylated [ATF2] . Positive_regulation ATF2 IL1B 16497991 1548955 Electrophoretic gel mobility shift assays showed that *increased* the binding of phosphorylated [ATF2] to CRE/ATF . Positive_regulation ATF2 MAP2K6 8626699 360647 Coupled kinase assays demonstrated that *induces* phosphorylation of [ATF2] by p38 but does not phosphorylate ATF2 directly . Positive_regulation ATF2 MMP28 21505267 2448829 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and [activating transcription factor] 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or . Positive_regulation ATF2 MMP7 21505267 2448845 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and [activating transcription factor] 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or . Positive_regulation ATF2 TLR7 18802113 1964867 IFN-gamma strongly enhanced *induced* expression of the transcriptional repressor [activating transcription factor] ( ATF-3 ) in a STAT1 dependent manner , which correlated with recruitment of ATF-3 to the endogenous MMP-1 promoter as detected by chromatin immunoprecipitation assays . Positive_regulation ATF2 TLR7 20351107 2260732 Interestingly , c-Src regulated *stimulated* induction of [activating transcription factor] 3 ( ATF3 ) , a transcriptional repressor . Positive_regulation ATF2 TLR7 24470589 2927614 Expression of the [activating transcription factor] 3 ( ATF3 ) gene is *induced* by signaling . Positive_regulation ATF2 TNF 10521481 653120 The study presented here shows that autoregulation of gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 mitogen activated protein (MAP) kinase activity and the binding of the transcription factors [ATF-2] and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation ATF2 TNF 10640438 577521 The transcription factors , c-Jun and ATF2 , are phosphorylated by the MAPKs and are implicated in the upregulation of c-Jun . IL-1 beta and *stimulated* the phosphorylation of c-Jun and [ATF2] . Positive_regulation ATF2 TNF 10777545 686839 Treatment of cells with okadaic acid elevated the alpha *induced* [ATF2] level and the extent of its specific N-terminal phosphorylation . Positive_regulation ATF2 TNF 11108246 756738 In addition , *induced* [activating transcription factor-1] phosphorylation is extensively decreased by SB203580 . Positive_regulation ATF2 TNF 12114204 964003 Finally , *increased* the phosphorylation of [ATF-2] , a transcription factor that is a p38 MAPK substrate . Positive_regulation ATF2 TNF 22198289 2558694 In addition , IL-1ß and *induced* the phosphorylation of [activating transcription factor-2] ( ATF-2 ) , but not c-Jun . Positive_regulation ATF2 TNF 24038085 2851648 Neutrophil stimulation with LPS or *led* to the phosphorylation , DNA binding activity , and chemokine promoter association of CREB1 and [activating transcription factor-1] . Positive_regulation ATF2 TNF 24069158 2847002 In addition , also *stimulated* c-Jun and [ATF2] phosphorylation which were inhibited by pretreatment with SP600125 and SB202190 , respectively , but not PD98059 . Positive_regulation ATF2 TNF 9006914 410778 stimulation of endothelial cells *induces* transient phosphorylation of both [ATF-2] and c-JUN and induces marked activation of the c-JUN N-terminal kinase ( JNK1 ) and p38 but not extracellular signal regulated kinase ( ERK1 ) . Positive_regulation ATF2 TNF 9317150 456271 In human endothelial cells , rapidly *induces* N-terminal domain phosphorylation of both c-Jun and [ATF2] . Positive_regulation ATF3 CCND1 11375399 834915 [Activating transcription factor] 3 *induces* DNA synthesis and expression of in hepatocytes . Positive_regulation ATF3 CTGF 11732999 885327 These inhibitors of MAPKK and MAPK suppressed phosphorylation of ets-like gene-1 (Elk-1) and nuclear [activating transcription factor-2] ( Atf-2 ) *induced* by in a dose dependent manner , respectively . Positive_regulation ATF3 EPHB2 15731359 1403030 We report that : 1 ) insulin induced transcription of [ATF-3] , Pip92 , and Insig-1 *required* activation ; Positive_regulation ATF3 EPHB2 18249159 1871632 Furthermore , JNK but not ERK is required for [ATF3] induction , and both and JNK are *necessary* for post-transcriptional induction of Fra1 in response to cisplatin or UV . Positive_regulation ATF3 EPHB2 22870894 2697311 H3S28 phosphorylation by itself appears not sufficient to induce PRC1/chromatin dissociation , nor ATF3 transcription , as inhibition of signaling *blocks* BMI1/chromatin dissociation and [ATF3] expression , despite induced H3S28 phosphorylation . Positive_regulation ATF3 MAP2K6 15731359 1403037 We report that : 1 ) insulin induced transcription of [ATF-3] , Pip92 , and Insig-1 *required* activation ; Positive_regulation ATF3 MAP2K6 22870894 2697317 H3S28 phosphorylation by itself appears not sufficient to induce PRC1/chromatin dissociation , nor ATF3 transcription , as inhibition of signaling *blocks* BMI1/chromatin dissociation and [ATF3] expression , despite induced H3S28 phosphorylation . Positive_regulation ATF3 MMP28 21505267 2448852 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and [activating transcription factor] 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or . Positive_regulation ATF3 MMP7 21505267 2448868 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and [activating transcription factor] 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or . Positive_regulation ATF3 TLR7 18802113 1964878 IFN-gamma strongly enhanced *induced* expression of the transcriptional repressor activating transcription factor ( [ATF-3] ) in a STAT1 dependent manner , which correlated with recruitment of ATF-3 to the endogenous MMP-1 promoter as detected by chromatin immunoprecipitation assays . Positive_regulation ATF3 TLR7 20351107 2260743 Interestingly , c-Src regulated *stimulated* induction of [activating transcription factor] 3 ( ATF3 ) , a transcriptional repressor . Positive_regulation ATF3 TLR7 22347845 2561054 [ATF3] is also *induced* by ligands but acts as a negative regulator of TLR signaling , suppressing the innate immune response which is involved in immuno-surveillance and can enhance or reduce the survival of injured neurons and promote the regeneration of their axons . Positive_regulation ATF3 TLR7 24470589 2927624 Expression of the [activating transcription factor] 3 ( ATF3 ) gene is *induced* by signaling . Positive_regulation ATF3 TNF 11108246 756739 In addition , *induced* [activating transcription factor-1] phosphorylation is extensively decreased by SB203580 . Positive_regulation ATF3 TNF 14723708 1197935 *induced* [ATF3] expression is bidirectionally regulated by the JNK and ERK pathways in vascular endothelial cells . Positive_regulation ATF3 TNF 14723708 1197937 In human umbilical vein endothelial cells , the expression of constitutively active MKK7 ( MAPK kinase 7 ) increased the number of ATF3 positive cells , and dominant negative MKK7 suppressed the *induced* expression of [ATF3] , indicating a requirement for the JNK pathway . Positive_regulation ATF3 TNF 14723708 1197938 In contrast , the expression of constitutively active or dominant negative MEK1/2 ( MAPK/ERK kinase 1/2 ) suppressed or enhanced *mediated* induction of [ATF3] , respectively . Positive_regulation ATF3 TNF 14723708 1197940 In support of this , the MEK1/2 specific inhibitor U0126 enhanced the expression of [ATF3] *induced* by . Positive_regulation ATF3 TNF 14723708 1197942 Our results suggest that *induced* [ATF3] gene expression is bidirectionally regulated by the JNK and ERK pathways in vascular endothelial cells . Positive_regulation ATF3 TNF 22198289 2558696 In addition , IL-1ß and *induced* the phosphorylation of [activating transcription factor-2] ( ATF-2 ) , but not c-Jun . Positive_regulation ATF3 TNF 24038085 2851649 Neutrophil stimulation with LPS or *led* to the phosphorylation , DNA binding activity , and chemokine promoter association of CREB1 and [activating transcription factor-1] . Positive_regulation ATF3 TNF 24196350 2875688 PGF treatment in vitro increased ATF3 expression only in LLC , whereas *induced* [ATF3] in both SLCs and LLCs . Positive_regulation ATF4 CCND1 11375399 834916 [Activating transcription factor] 3 *induces* DNA synthesis and expression of in hepatocytes . Positive_regulation ATF4 CTGF 11732999 885341 These inhibitors of MAPKK and MAPK suppressed phosphorylation of ets-like gene-1 (Elk-1) and nuclear [activating transcription factor-2] ( Atf-2 ) *induced* by in a dose dependent manner , respectively . Positive_regulation ATF4 EPHB2 22790938 2628162 Furthermore , pathway analyses using the various signaling pathway-specific inhibitors revealed that JNK activation , but not activation , is *essential* for CBP induced mineralization and [ATF4] expression . Positive_regulation ATF4 MAP2K6 18287093 1891419 Consequently , inhibition of activation *blocked* transcriptional induction of [ATF4] target genes , but the induction was rescued by overexpression of ATF4 protein . Positive_regulation ATF4 MMP28 21505267 2448875 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and [activating transcription factor] 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or . Positive_regulation ATF4 MMP7 21505267 2448891 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and [activating transcription factor] 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or . Positive_regulation ATF4 TLR7 18802113 1964889 IFN-gamma strongly enhanced *induced* expression of the transcriptional repressor [activating transcription factor] ( ATF-3 ) in a STAT1 dependent manner , which correlated with recruitment of ATF-3 to the endogenous MMP-1 promoter as detected by chromatin immunoprecipitation assays . Positive_regulation ATF4 TLR7 20351107 2260754 Interestingly , c-Src regulated *stimulated* induction of [activating transcription factor] 3 ( ATF3 ) , a transcriptional repressor . Positive_regulation ATF4 TLR7 23241898 2724545 In this report , we found that [ATF4] is also involved in the *mediated* innate immune response , which participates in TLR4 signal transduction and mediates the secretion of a variety of cytokines . Positive_regulation ATF4 TLR7 24470589 2927634 Expression of the [activating transcription factor] 3 ( ATF3 ) gene is *induced* by signaling . Positive_regulation ATF4 TNF 11108246 756740 In addition , *induced* [activating transcription factor-1] phosphorylation is extensively decreased by SB203580 . Positive_regulation ATF4 TNF 22198289 2558698 In addition , IL-1ß and *induced* the phosphorylation of [activating transcription factor-2] ( ATF-2 ) , but not c-Jun . Positive_regulation ATF4 TNF 22319522 2553782 PTX ( 1 mM ) reduced induced *activation* of GRP78 , p-eIF2 , [ATF4] , IRE1a , and CHOP in vitro . Positive_regulation ATF4 TNF 24038085 2851650 Neutrophil stimulation with LPS or *led* to the phosphorylation , DNA binding activity , and chemokine promoter association of CREB1 and [activating transcription factor-1] . Positive_regulation ATF4 TNF 24080827 2847616 Our data therefore revealed a role of ER stress and [ATF4/CHOP] in the ethanol induced inhibition of osteogenesis , and *activation* of signaling by ATF4/CHOP linking ER stress to adipogenic lineage in response to alcohol stimulation . Positive_regulation ATF5 CCND1 11375399 834917 [Activating transcription factor] 3 *induces* DNA synthesis and expression of in hepatocytes . Positive_regulation ATF5 CTGF 11732999 885355 These inhibitors of MAPKK and MAPK suppressed phosphorylation of ets-like gene-1 (Elk-1) and nuclear [activating transcription factor-2] ( Atf-2 ) *induced* by in a dose dependent manner , respectively . Positive_regulation ATF5 MMP28 21505267 2448898 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and [activating transcription factor] 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or . Positive_regulation ATF5 MMP7 21505267 2448914 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and [activating transcription factor] 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or . Positive_regulation ATF5 TLR7 18802113 1964900 IFN-gamma strongly enhanced *induced* expression of the transcriptional repressor [activating transcription factor] ( ATF-3 ) in a STAT1 dependent manner , which correlated with recruitment of ATF-3 to the endogenous MMP-1 promoter as detected by chromatin immunoprecipitation assays . Positive_regulation ATF5 TLR7 20351107 2260765 Interestingly , c-Src regulated *stimulated* induction of [activating transcription factor] 3 ( ATF3 ) , a transcriptional repressor . Positive_regulation ATF5 TLR7 24470589 2927644 Expression of the [activating transcription factor] 3 ( ATF3 ) gene is *induced* by signaling . Positive_regulation ATF5 TNF 11108246 756741 In addition , *induced* [activating transcription factor-1] phosphorylation is extensively decreased by SB203580 . Positive_regulation ATF5 TNF 22198289 2558700 In addition , IL-1ß and *induced* the phosphorylation of [activating transcription factor-2] ( ATF-2 ) , but not c-Jun . Positive_regulation ATF5 TNF 24038085 2851651 Neutrophil stimulation with LPS or *led* to the phosphorylation , DNA binding activity , and chemokine promoter association of CREB1 and [activating transcription factor-1] . Positive_regulation ATF6 CCND1 11375399 834918 [Activating transcription factor] 3 *induces* DNA synthesis and expression of in hepatocytes . Positive_regulation ATF6 CTGF 11732999 885369 These inhibitors of MAPKK and MAPK suppressed phosphorylation of ets-like gene-1 (Elk-1) and nuclear [activating transcription factor-2] ( Atf-2 ) *induced* by in a dose dependent manner , respectively . Positive_regulation ATF6 EPHB2 24240056 2892379 Inhibition of MEK partially blocked IRE1a and ATF6 activation , suggesting that signaling *contributed* to sustained activation of IRE1a and [ATF6] . Positive_regulation ATF6 MAP2K6 24240056 2892385 Inhibition of partially *blocked* IRE1a and [ATF6] activation , suggesting that MEK/ERK signaling contributed to sustained activation of IRE1a and ATF6 . Positive_regulation ATF6 MMP28 21505267 2448921 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and [activating transcription factor] 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or . Positive_regulation ATF6 MMP7 21505267 2448937 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and [activating transcription factor] 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or . Positive_regulation ATF6 TLR7 18802113 1964911 IFN-gamma strongly enhanced *induced* expression of the transcriptional repressor [activating transcription factor] ( ATF-3 ) in a STAT1 dependent manner , which correlated with recruitment of ATF-3 to the endogenous MMP-1 promoter as detected by chromatin immunoprecipitation assays . Positive_regulation ATF6 TLR7 20351107 2260776 Interestingly , c-Src regulated *stimulated* induction of [activating transcription factor] 3 ( ATF3 ) , a transcriptional repressor . Positive_regulation ATF6 TLR7 24470589 2927654 Expression of the [activating transcription factor] 3 ( ATF3 ) gene is *induced* by signaling . Positive_regulation ATF6 TNF 11108246 756742 In addition , *induced* [activating transcription factor-1] phosphorylation is extensively decreased by SB203580 . Positive_regulation ATF6 TNF 22198289 2558702 In addition , IL-1ß and *induced* the phosphorylation of [activating transcription factor-2] ( ATF-2 ) , but not c-Jun . Positive_regulation ATF6 TNF 24038085 2851652 Neutrophil stimulation with LPS or *led* to the phosphorylation , DNA binding activity , and chemokine promoter association of CREB1 and [activating transcription factor-1] . Positive_regulation ATF7 CCND1 11375399 834919 [Activating transcription factor] 3 *induces* DNA synthesis and expression of in hepatocytes . Positive_regulation ATF7 CTGF 11732999 885383 These inhibitors of MAPKK and MAPK suppressed phosphorylation of ets-like gene-1 (Elk-1) and nuclear [activating transcription factor-2] ( Atf-2 ) *induced* by in a dose dependent manner , respectively . Positive_regulation ATF7 MMP28 21505267 2448944 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and [activating transcription factor] 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or . Positive_regulation ATF7 MMP7 21505267 2448960 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and [activating transcription factor] 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or . Positive_regulation ATF7 TLR7 18802113 1964922 IFN-gamma strongly enhanced *induced* expression of the transcriptional repressor [activating transcription factor] ( ATF-3 ) in a STAT1 dependent manner , which correlated with recruitment of ATF-3 to the endogenous MMP-1 promoter as detected by chromatin immunoprecipitation assays . Positive_regulation ATF7 TLR7 20351107 2260787 Interestingly , c-Src regulated *stimulated* induction of [activating transcription factor] 3 ( ATF3 ) , a transcriptional repressor . Positive_regulation ATF7 TLR7 24470589 2927664 Expression of the [activating transcription factor] 3 ( ATF3 ) gene is *induced* by signaling . Positive_regulation ATF7 TNF 11108246 756743 In addition , *induced* [activating transcription factor-1] phosphorylation is extensively decreased by SB203580 . Positive_regulation ATF7 TNF 22198289 2558704 In addition , IL-1ß and *induced* the phosphorylation of [activating transcription factor-2] ( ATF-2 ) , but not c-Jun . Positive_regulation ATF7 TNF 24038085 2851653 Neutrophil stimulation with LPS or *led* to the phosphorylation , DNA binding activity , and chemokine promoter association of CREB1 and [activating transcription factor-1] . Positive_regulation ATG5 CAPN8 20406981 2246197 Conversely , Ad . mda-7 infection elicited *mediated* cleavage of the autophagic protein [ATG5] in a manner that could facilitate switch to apoptosis . Positive_regulation ATG5 FAS 18719356 1961599 We noted , however , in these systems that , in parallel with death receptor induced activation of the extrinsic pathway , signaling also *promoted* increased phosphorylation of PKR-like endoplasmic reticulum kinase ( PERK ) and eIF2alpha , increased expression of [ATG5] , and increased processing of LC3 and vesicularization of a GFP-LC3 construct . Positive_regulation ATG7 EPHB2 22634147 2632516 The activated reactive oxygen signal *promoted* [Atg7] protein expression , which triggered MS-275 induced cancer cell autophagy . Positive_regulation ATG7 TNF 22869322 2682529 In addition , acylated ghrelin reduced the basal expression of the autophagy related genes ATG5 and ATG7 , while desacyl ghrelin inhibited the *induced* increase of ATG5 , BECN1 and [ATG7] expression . Positive_regulation ATL1 ALOX5 15326064 1290590 When [ATL] synthesis was *inhibited* by pretreatment with a selective cyclooxygenase-2 inhibitor ( celecoxib ) or a <5-lipoxygenase> inhibitor ( zileuton ) , the aspirin induced increase in BP was significantly augmented . Positive_regulation ATL2 ALOX5 15326064 1290591 When [ATL] synthesis was *inhibited* by pretreatment with a selective cyclooxygenase-2 inhibitor ( celecoxib ) or a <5-lipoxygenase> inhibitor ( zileuton ) , the aspirin induced increase in BP was significantly augmented . Positive_regulation ATL3 ALOX5 15326064 1290592 When [ATL] synthesis was *inhibited* by pretreatment with a selective cyclooxygenase-2 inhibitor ( celecoxib ) or a <5-lipoxygenase> inhibitor ( zileuton ) , the aspirin induced increase in BP was significantly augmented . Positive_regulation ATM CLU 23051594 2702836 FOXL2 directly stimulates the Clu gene promoter , and we show that PTTG triggers [ataxia telangiectasia mutated] kinase/IGF-I/p38MAPK DNA damage/chromosomal instability signaling , which in turn also *induces* expression . Positive_regulation ATM STAT4 15000861 1216959 Apoptosis effected by TNF-alpha alone was suppressed by [ATA] and this event was *paralleled* by phosphorylation and nuclear translocation of Jak2 , Stat2 , and NF-kB , along with inhibition of caspase activation . Positive_regulation ATOH1 MSX1 24715462 2931950 In vitro , and Msx2 proteins *activate* [Atoh1] transcription by specifically interacting with several homeodomain binding sites in the Atoh1 3 ' enhancer . Positive_regulation ATOH1 MSX1 24715462 2931951 In vivo , and Msx2 are *required* for [Atoh1] 3 ' enhancer activity and ChIP experiments confirm Msx1 binding to this regulatory sequence . Positive_regulation ATP2A2 CAPN8 16155100 1499459 Ischemia-reperfusion induced calpain activation and [SERCA2a] degradation are *attenuated* by exercise training and inhibition . Positive_regulation ATP2A2 EPHB2 24508653 2923988 Moreover , high expression of [SERCA2b] *induced* accumulation of ROS and enhanced signaling , thus leading to inactivation of PPAR-? and down-regulation of adipocyte-specific genes . Positive_regulation ATP2A2 HBEGF 16939417 1673108 Depletion of the using ADP , which releases Ca2+ solely from the DTS , in combination with 10 nM TG , to selectively *inhibit* [SERCA2] located on the DTS reduced Ca2+ release evoked by the PAR-1 agonist , SFLLRN , and the PAR-4 agonist , AYPGKF , by 80 and 50 % respectively . Positive_regulation ATP5J TNF 15158150 1250635 We investigated the *role* of in the generation and release of [CF6] . Positive_regulation ATP5J TNF 15158150 1250637 *stimulates* the gene expression of [CF6] via activation of NF-kappa B signaling pathway , and promotes the release of CF6 from ECV-304 and HUVEC . Positive_regulation ATP5J TNF 18819888 1970309 To investigate the effect of rosiglitazone on the expression of nuclear factor-kappaB (NF-kappaB) and [coupling factor 6 (CF6)] *induced* by in cultured human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation ATP5J TNF 18819888 1970311 Pretreatment of HUVECs with rosiglitazone inhibited *induced* expression of [CF6] in a dose dependent manner . Positive_regulation ATP5J TNF 18819888 1970312 *induced* enhancement of the gene expression and release of [CF6] is mediated by activation of NF-kappaB signaling pathway . Positive_regulation ATP5O ABCA4 11278627 798299 Photodamage to causes it to aggregate in SDS gels and *results* in the loss of retinal stimulated [ATPase] activity . Positive_regulation ATP5O ABCG2 11437380 832779 Here we report that the expression of the protein in Sf9 insect cells *resulted* in a high-capacity , vanadate-sensitive [ATPase] activity in isolated membrane preparations . Positive_regulation ATP5O AGR2 9889388 585399 On the other hand , the [Na+-ATPase] activity was enhanced 100 % in the presence of cholera toxin and 85 % in the *presence* of both and cholera toxin . Positive_regulation ATP5O AGR2 9889388 585400 Taken together , these data suggest that *activates* the [Na+-ATPase] activity through AT1 receptors coupled to a pertussis-insensitive and cholera-sensitive G-protein . Positive_regulation ATP5O ARSA 8196511 259191 In addition , plus Ca2+ *increased* state 4 respiration and [ATPase] activity . Positive_regulation ATP5O CA12 16331978 1491164 In agreement with prior measurements in cardiac SR microsomes , the calcium concentration associated with half-maximal *activation* ( ) of the [Ca-ATPase] , 290 +/- 10 nM , is shifted to 580 +/- 20 nM when co-reconstituted with PLB ( C ) ( Pro21 ) as a result of a reduction in the cooperativity associated with the calcium dependent structural transition . Positive_regulation ATP5O CAPN8 20393603 2240505 Ischemia-reperfusion induced changes in sarcolemmal [Na+/K+-ATPase] are *due* to the activation of in the heart . Positive_regulation ATP5O CAPN8 2825780 81015 *Activation* of erythrocyte membrane [Ca2+-ATPase] by . Positive_regulation ATP5O CAPN8 2829740 84896 We now demonstrate a similar kind of *activation* of the human erythrocyte membrane [Ca2+-ATPase] by ( calcium dependent neutral protease ) isolated from the human red cell cytosol . Positive_regulation ATP5O CCND1 23028124 2702544 [Na+/K+-ATPase] a1 isoform mediates ouabain *induced* expression of and proliferation of rat sertoli cells . Positive_regulation ATP5O CLU 18256250 1865593 The persistent increase in *required* intact alpha2/alpha3 [Na+-K+-ATPase] activity , indicating that trains of action potentials reset the thermodynamic equilibrium for NKCC1 transport by lowering Na ( i ) . Positive_regulation ATP5O EDN2 1650145 162969 *stimulates* Na ( + ) -K ( + ) [-ATPase] activity by a protein kinase C-dependent pathway in rabbit aorta . Positive_regulation ATP5O EPHB2 12676735 1076815 Isoproterenol increased phosphorylation of ERK in a PKA dependent manner , and inhibition of the phosphorylation *prevented* the stimulation of [H-K-ATPase] . Positive_regulation ATP5O EPHB2 14985981 1236681 Exogenous PGE ( 2 ) *reduced* protein expression of the [ATPase] within 15 min , even in presence of an inhibitor . Positive_regulation ATP5O EPHB2 16973240 1647002 We conclude that leptin induced stimulation of renal Na ( + ) , K ( + ) [-ATPase] *involves* H ( 2 ) O ( 2 ) generation , Src kinase , transactivation of the EGF receptor , and stimulation of . Positive_regulation ATP5O EPHB2 18550646 1940619 PTH mediated regulation of [Na+-K+-ATPase] *requires* Src kinase dependent phosphorylation . Positive_regulation ATP5O F2R 9064647 414180 Thus , the control by PKC of the capacitative Ca2+ entry is apparently different depending on whether it is induced by sarco/endoplasmic reticulum [Ca2+-ATPase] inhibition or by *activation* of the . Positive_regulation ATP5O IL1B 14644757 1210220 Epithelial Na+ channel and [Na+-K+-ATPase] subunit expressions were both *increased* by and attenuated by cortisol synthesis inhibition . Positive_regulation ATP5O IL1B 16085671 1473897 Epithelial sodium channel and [Na-K-ATPase] subunit expressions were both *increased* by , but not further by oxytocin . Positive_regulation ATP5O NT5E 6135422 29077 Acetaldehyde produced non-competitive inhibition of ( Na+K+ ) ATPase and Mg2+ [ATPase] at concentrations of 6 and 56 mM respectively and <5' nucleotidase> activity was also *inhibited* at these concentrations . Positive_regulation ATP5O NT5E 8527971 336663 The marker enzyme assays revealed that the SL fraction was enriched with <5'-nucleotidase> and the Na ( + ) -K ( + ) [-ATPase] activity *increased* over 20-fold , while the LV fraction showed very little enrichment when compared with the homogenate . Positive_regulation ATP5O PGC 21687978 2455566 Na , [K-ATPase] activity in mouse muscle is *regulated* by AMPK and . Positive_regulation ATP5O RAB31 11062069 746562 Furthermore , we found that and Rab4 can also associate with NSF and *stimulate* its [ATPase] activity . Positive_regulation ATP5O SYT8 16713576 1564952 induces a 4-fold *increase* in the [ATPase] activity of wild-type p97/VCP ( p97/VCP ( wt ) ) , but not in mutants that showed an ERAD impairment . Positive_regulation ATP5O TF 12962278 1138509 Moreover , was also *required* for low-K ( + ) -induced increases in al-subunit promoter activity , al- and el-subunit protein abundance of the Na , [K-ATPase] . Positive_regulation ATP5O TMEM100 21220422 2408415 [Na/K-ATPase] ( NKA ) activity is dynamically *regulated* by an inhibitory interaction with a small , phospholemman (PLM) . Positive_regulation ATP5O TMEM100 7918987 272492 The [Ca-ATPase] in the cardiac sarcoplasmic reticulum membrane is *regulated* by an amphipathic , phospholamban . Positive_regulation ATP5O TMEM156 21220422 2408433 [Na/K-ATPase] ( NKA ) activity is dynamically *regulated* by an inhibitory interaction with a small , phospholemman (PLM) . Positive_regulation ATP5O TMEM156 7918987 272510 The [Ca-ATPase] in the cardiac sarcoplasmic reticulum membrane is *regulated* by an amphipathic , phospholamban . Positive_regulation ATP5O TMEM211 21220422 2408513 [Na/K-ATPase] ( NKA ) activity is dynamically *regulated* by an inhibitory interaction with a small , phospholemman (PLM) . Positive_regulation ATP5O TMEM211 7918987 272590 The [Ca-ATPase] in the cardiac sarcoplasmic reticulum membrane is *regulated* by an amphipathic , phospholamban . Positive_regulation ATP5O TMEM213 21220422 2408450 [Na/K-ATPase] ( NKA ) activity is dynamically *regulated* by an inhibitory interaction with a small , phospholemman (PLM) . Positive_regulation ATP5O TMEM213 7918987 272527 The [Ca-ATPase] in the cardiac sarcoplasmic reticulum membrane is *regulated* by an amphipathic , phospholamban . Positive_regulation ATP5O TMOD1 11955019 930714 The cross linked in the `` potentiated-open '' state *allowed* strong interaction and full [ATPase] activity of S1 as described previously . Positive_regulation ATP5O TMOD1 11955019 930717 The cross linked in the `` on-closed '' state *allowed* strong interactions with S1 and actin activated [ATPase] without enhancing the 2nd LL to the level of `` potentiated-open '' state , contrary to the expectations from the biochemical studies . Positive_regulation ATP5O TMOD1 14596793 1160331 cAMP dependent protein kinase (PKA) dependent phosphorylation of the two serine residues in the amino terminal region unique to cardiac troponin I (cTnI) is known to cause two effects : ( i ) decrease of the maximum Ca2+ controlled *activated* myosin [S1-ATPase] ( actoS1-ATPase ) activity and mean sliding velocity of reconstituted thin filaments ; Positive_regulation ATP5O TNF 1338337 209129 and LPS , but not IFN gamma , *stimulated* BMM Na+/H+ exchange and Na+ , K ( + ) [-ATPase] activities , as well as c-fos mRNA levels . Positive_regulation ATP6V0D2 MITF 23379601 2758970 In contrast , 17-AAG treatment ( and RANKL treatment ) increased both MITF ( microphthalmia associated transcription factor ) protein levels and *dependent* vATPase-d2 ( [V-type proton ATPase subunit d2] ) gene promoter activity . Positive_regulation ATP7A CLU 22130675 2542333 and COMMD1 independently *regulate* degradation of the mammalian copper ATPases [ATP7A] and ATP7B . Positive_regulation ATP7A RARB 19127267 2019615 Taken together , our data demonstrates [ATP7A] expression is *regulated* by and it has effects on intracellular copper levels , revealing a link between the anticancer action of retinoids and copper metabolism . Positive_regulation ATP8A2 IL1B 9257931 448557 Submaximal stimuli used for further experiments were IFNgamma 100 u ml(-1) , IL-1beta 1 u [ml(-1)] and LPS 10 microg ml(-1) to *induce* both the iNOS and COX-2 pathways , and 3 u ml(-1) to induce COX-2 without iNOS activity . Positive_regulation ATP8A2 TNF 11334131 809203 Systemic levels before BAL ( pneumonia : 35 ( 10-88 ) ; controls : 17 ( 0-33 ) pg x mL(-1) ) did not *increase* at 12 h ( pneumonia : 35 ( 0-64 ) ; p=0.735 ; controls : 16 ( 0-21 ) pg x mL(-1) , p=0.123 comparison to baseline ) or 24 h ( pneumonia : 31 ( 0-36 ) , p=0.464 ; controls : 19 ( 0-43 ) pg x [mL(-1)] , p=0.358 ) . Positive_regulation ATP8A2 TNF 12575320 1029620 When the concentrations of nicotine were 50 ng . ml-1 and 500 ng . [ml-1] , the level of *increased* significantly in non-smokers ( P < 0.05 , P < 0.01 ) . Positive_regulation ATP8A2 TNF 14724215 1225980 During endotoxaemia , *increased* in the IF from 0 in control to 640 +/- 100 pg [ml(-1)] ( mean +/-s.e.m. ) after 90 min , with the serum concentration being 5-10 times higher at all time points . Positive_regulation ATP8A2 TNF 8352018 227262 [ml-1] ) *induced* the release of from PA-primed mouse peritoneal macrophages in dose- and time dependent manners in vitro , and the effects of TPA and LPS were inhibited by H-7 ( 12.5-100 mumol . Positive_regulation ATP8A2 TNF 8933823 344961 Regarding cytokine secretion , IL-6 and production was *induced* by 10 ng/ml [ML-I] . Positive_regulation ATP8A2 TNF 9848688 554044 RAW 264.7 cells ( 2 x 10 ( 5 ) cells ml(-1) ) were stimulated with these LPS preparations at 1 microg [ml(-1)] for 48 h. Re595 LPS , Re595 LA and Re595 MPLA significantly *induced* NO , and IL-6 production ; Positive_regulation ATR ETV7 20801936 2318215 Analysis of in vivo labeled nascent protein complexes showed that and Hsp90 *mediate* the formation of the mTOR TORC1 and TORC2 complexes and the association of [ATR] with ATRIP . Positive_regulation ATXN1 S100B 20477910 2288582 Taken together our data support a mechanism where PKA dependent mutant [ataxin-1] phosphorylation and aggregation can be *regulated* by signaling . Positive_regulation AURKA NEDD9 23539442 2782554 Here , we show that , a known activator of AURKA , is directly *involved* in [AURKA] stability . Positive_regulation AURKC TNF 21715338 2465903 CCAAT/enhancer binding protein delta mediates alpha *induced* [Aurora kinase C] transcription and promotes genomic instability . Positive_regulation AVEN NES 20935510 2337807 Disruption of this by site directed mutagenesis *resulted* in enhanced nuclear localization of [Aven] , but did not alter the ability of the protein to induce G ( 2 ) /M cell cycle arrest in interphase Xenopus laevis extracts . Positive_regulation AVP ANGPT1 20371731 2255540 Intracerebroventricular significantly *increased* fetal blood pressure and c-fos expression in the supraoptic nuclei (SON) and the paraventricular nuclei ( PVN ) in the hypothalamus , accompanied by an increase of fetal plasma [arginine vasopressin (AVP)] . Positive_regulation AVP IL1B 14698853 1195823 To investigate whether this peptide hyporesponsiveness in LEW/N cells is secondary to their deficient mRNA expression , temporal mRNA expression patterns of CRH , [AVP] , and several hypothalamic neuropeptides *induced* by in LEW/N and F344/N hypothalamic dissociated cell cultures were delineated by quantitative real-time polymerase chain reaction ( RT-PCR ) . Positive_regulation AVP IL1B 7566434 328499 IL-1 alpha ( 0.2 ng/ml ) , ( 0.5 ng/ml ) and IL-6 ( 10 ng/ml ) also *initiated* similar increases in the release of CRF-41 and [AVP] from hypothalami from intact rats which were effectively blocked by dexamethasone ( 10 ( -7 ) M ) . Positive_regulation AVP IL1B 7689960 228539 L-arginine also reduced *stimulated* [AVP] release . Positive_regulation AVP IL1B 7931009 275175 These data suggest an inverse relationship between circulating levels of glucocorticoids and the ability of to *stimulate* plasma [AVP] . Positive_regulation AVP IL1B 8049716 267489 We have therefore used a previously validated rat hypothalamic explant model to evaluate whether and IL-6 can directly *activate* the [AVP] and oxytocin neurosecretory system . Positive_regulation AVP IL1B 8159270 254320 ( 100 U/ml ) had no effect on the basal AVP release from the hypothalamus , but significantly *potentiated* the acetylcholine induced [AVP] release , lowering the threshold from 500 to 100 nM . Positive_regulation AVP IL1B 8396869 230342 In the LIL group , *increased* blood pressure , body temperature and plasma [AVP] and ANP without any changes in heart rate ( HR ) and plasma ACTH . Positive_regulation AVP IL1B 8693488 343288 *increased* significantly plasma ANP and [AVP] and UNa V , but not UF , accompanied by decreases in Posm and UKV and increases in MABP ( ExI ) . Positive_regulation AVP IL1B 9266547 407999 *induced* effects on plasma oxytocin and [arginine vasopressin] : role of adrenal steroids and route of administration . Positive_regulation AVP TNF 8159270 254322 Neither nor interferon-gamma *had* any effect on the basal or acetylcholine induced [AVP] release from the hypothalamus . Positive_regulation AVP TNF 8646562 343011 In vivo evidence that [arginine vasopressin] is involved in the adrenocorticotropin response *induced* by interleukin-6 but not by in the rat . Positive_regulation AVP TNF 8646562 343013 We examined whether [arginine vasopressin (AVP)] is involved in the adrenocorticotropin ( ACTH ) response *induced* by interleukin (IL)-6 or in the rat . Positive_regulation AVPR2 RGS2 17475820 1744139 This study provides evidence that [V2R] signaling is negatively *regulated* by ( RGS2 ) , a member of the family of RGS proteins . Positive_regulation AXIN2 AMER1 21498506 2434724 *stabilizes* [Axin] and counteracts Wnt induced degradation of Axin , which requires membrane localization of Amer1 . Positive_regulation AXIN2 APBB1 19796171 2147978 These results suggest that the translocation of to the nuclear matrix , along with the formation of nuclear patches , is *required* for the stabilization of p53 by its suppression of the proteasome degradation pathway , thus facilitating the subsequent induction of [gammaH2AX in] osmotically stressed cells . Positive_regulation AXIN2 APC 10722668 677142 These results suggest that *requires* interaction with [Axin] and beta-catenin to down-regulate beta-catenin . Positive_regulation AXIN2 APC 16798748 1579129 binds beta-catenin and is *involved* in the [Axin] complex , suggesting that APC regulates beta-catenin phosphorylation . Positive_regulation AXIN2 CDC20 22322943 2592203 We propose that *mediated* degradation of [conductin] regulates Wnt/ß-catenin signalling for maximal activity during G1/S . Positive_regulation AXIN2 CDK2 15063782 1230952 *regulates* the interaction of [Axin] with beta-catenin . Positive_regulation AXIN2 CDK5 21940452 2487653 *mediated* phosphorylation of [Axin] directs axon formation during cerebral cortex development . Positive_regulation AXIN2 CDK5 21940452 2487655 Together , our findings reveal a new regulatory mechanism of axon formation through *dependent* phosphorylation of [Axin] . Positive_regulation AXIN2 CDK5 23972596 2832860 The nuclear localization of Axin and hence the switch of IPs from proliferative to differentiative status are strictly controlled by the *dependent* phosphorylation of [Axin] at Thr485 . Positive_regulation AXIN2 CDX2 23393221 2787051 Transfection of intestinal and non-intestinal cell lines demonstrated that *activated* APC and [AXIN2] promoter activities via intestinal cell-specific enhancer elements . Positive_regulation AXIN2 CRS 23300083 2742248 To determine whether Runx2 contributes to the etiology of [Axin2] deficiency *induced* , we generated Axin2 ( -/- ) : Runx2 ( +/- ) mice . Positive_regulation AXIN2 CSNK1E 19141611 2042945 The Ser and Thr residues in the motif appear to be also phosphorylated by glycogen synthase kinase 3beta ( GSK3beta ) and the CKI family kinases , as GSK3beta and could *enhance* the interaction of Zbed3 with [Axin] . Positive_regulation AXIN2 CTNNB1 11809808 906714 signaling *induces* the transcription of [Axin2] , a negative regulator of the signaling pathway . Positive_regulation AXIN2 CTNNB1 11809809 906816 Wnt signaling is controlled by the negative regulator [conductin/axin2/axil] , which *induces* degradation of by functional interaction with the tumor suppressor APC and the serine/threonine kinase GSK3beta . Positive_regulation AXIN2 CTNNB1 16764864 1576491 This optimal level is determined by balancing signaling and the *induction* of [Axin2] that acts as a potent negative feedback . Positive_regulation AXIN2 CTNNB1 19888210 2161368 We show that Ube2m interacts with and modulates stability , and that the antagonistic effect of Nkd1 on Wnt signaling *requires* interaction with [Axin] , itself a negative pathway regulator . Positive_regulation AXIN2 CTNNB1 20303851 2230538 [Axin2] is *activated* by , which in turn is degraded by a complex of GSK3beta and Axin2 . Positive_regulation AXIN2 CTNNB1 9554852 499569 [Conductin] *induced* degradation , whereas mutants of conductin that were deficient in complex formation stabilized beta-catenin . Positive_regulation AXIN2 DAAM2 22227309 2544649 Moreover , *stabilizes* [Dvl3/Axin2] binding , resulting in enhanced intracellular assembly of Dvl3/Axin2 complexes . Positive_regulation AXIN2 DAB2 12805222 1101609 In addition , we find that can associate with axin in vitro and *stabilize* [axin] expression in vivo . Positive_regulation AXIN2 DAB2 17922036 1882542 levels induced during retinoic acid induced differentiation of F9 , or during transforming growth factor-beta induced epithelial-mesenchymal transdifferentiation of mouse mammary epithelial cells *result* in the stabilization of [Axin] and concomitant inhibition of beta-catenin signaling . Positive_regulation AXIN2 DAB2 17922036 1882546 Ectopic expression of in F9 cells as well as in transformed cell lines *results* in increased [Axin] expression and attenuation of Wnt mediated signaling . Positive_regulation AXIN2 DAB2 19581931 2122342 *stabilizes* [Axin] and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions . Positive_regulation AXIN2 DAB2 19581931 2122527 We conclude that *stabilizes* [Axin] and attenuates Wnt/beta-catenin signaling by preventing PP1 from binding Axin . Positive_regulation AXIN2 DNMT3A 19454286 2128273 This mechanism is likely to play a role in human colorectal cancer , because we also show that elevated expression coincides with repressed SFRP5 and *enhanced* [AXIN2/CONDUCTIN] expression in paired patient biopsies . Positive_regulation AXIN2 E2F1 15572025 1355623 Cross-talk between pRb/E2F and Wnt/beta-catenin pathways : *induces* [axin2] leading to repression of Wnt signalling and to increased cell death . Positive_regulation AXIN2 E2F1 15766563 1383689 [Axin2] is *induced* by and therefore acts as a point of cross-talk between the pRb/E2F and Wnt/beta-catenin pathways : two of the most frequently deregulated pathways in human cancers . Positive_regulation AXIN2 FERMT2 22699938 2633775 Mechanistically , selectively strengthens the occupancy of ß-catenin on the Wnt target gene Axin2 and *enhances* [Axin2] gene expression . Positive_regulation AXIN2 GSK3B 10944533 744113 Axam inhibited the complex formation of Dvl with Axin and the activity of Dvl to suppress *dependent* phosphorylation of [Axin] . Positive_regulation AXIN2 GSK3B 19141611 2042946 The Ser and Thr residues in the motif appear to be also phosphorylated by glycogen synthase kinase 3beta ( GSK3beta ) and the CKI family kinases , as and CKIepsilon could *enhance* the interaction of Zbed3 with [Axin] . Positive_regulation AXIN2 LACE1 23907605 2835769 In addition , *increased* 8-OHdG and [?H2AX in] the nuclies and induced S phase arrest and DNA damage in B-2A13 cells , and the proteins related to DNA damage responses , such as ATM , ATR , Chk2 , p53 , BRCA1 , and ?H2AX , were activated . Positive_regulation AXIN2 LEF1 11336703 812116 In contrast , LRP-5 mutants lacking the extracellular domain functioned as constitutively active forms that bind [Axin] and that *induce* activation by destabilizing Axin and stabilizing beta-catenin . Positive_regulation AXIN2 LRP1 16443747 1516967 These involve activation of Dishevelled ( Dsh ) , possibly through trimeric G proteins and *mediated* [axin] binding and/or degradation . Positive_regulation AXIN2 LRP10 16443747 1516964 These involve activation of Dishevelled ( Dsh ) , possibly through trimeric G proteins and *mediated* [axin] binding and/or degradation . Positive_regulation AXIN2 LRP11 16443747 1516965 These involve activation of Dishevelled ( Dsh ) , possibly through trimeric G proteins and *mediated* [axin] binding and/or degradation . Positive_regulation AXIN2 LRP12 16443747 1516966 These involve activation of Dishevelled ( Dsh ) , possibly through trimeric G proteins and *mediated* [axin] binding and/or degradation . Positive_regulation AXIN2 LRP2 16443747 1516968 These involve activation of Dishevelled ( Dsh ) , possibly through trimeric G proteins and *mediated* [axin] binding and/or degradation . Positive_regulation AXIN2 LRP3 16443747 1516969 These involve activation of Dishevelled ( Dsh ) , possibly through trimeric G proteins and *mediated* [axin] binding and/or degradation . Positive_regulation AXIN2 LRP4 16443747 1516970 These involve activation of Dishevelled ( Dsh ) , possibly through trimeric G proteins and *mediated* [axin] binding and/or degradation . Positive_regulation AXIN2 LRP5 16443747 1516971 These involve activation of Dishevelled ( Dsh ) , possibly through trimeric G proteins and *mediated* [axin] binding and/or degradation . Positive_regulation AXIN2 LRP6 16443747 1516972 These involve activation of Dishevelled ( Dsh ) , possibly through trimeric G proteins and *mediated* [axin] binding and/or degradation . Positive_regulation AXIN2 LRP6 17202189 1680718 Wnt11/beta-catenin signaling in both oocytes and early embryos acts through *mediated* regulation of [axin] . Positive_regulation AXIN2 LRP6 17202189 1680724 In the full-grown oocyte , before maturation , we find that [axin] levels are also *regulated* by Wnt11 and . Positive_regulation AXIN2 LRP6 17202189 1680734 In the oocyte , Wnt11 and/or *regulates* [axin] to maintain beta-catenin at a low level , while in the embryo , asymmetrical Wnt11/LRP6 signaling stabilizes beta-catenin and enriches it on the dorsal side . Positive_regulation AXIN2 LRP8 16443747 1516973 These involve activation of Dishevelled ( Dsh ) , possibly through trimeric G proteins and *mediated* [axin] binding and/or degradation . Positive_regulation AXIN2 MEN1 19074834 2002643 overexpression *increases* expression of the Wnt/beta-catenin downstream target gene [Axin2] , which is associated with increased H3K4 trimethylation of the Axin2 gene promoter . Positive_regulation AXIN2 NKD1 19888210 2161367 We show that Ube2m interacts with and modulates beta-catenin stability , and that the antagonistic effect of on Wnt signaling *requires* interaction with [Axin] , itself a negative pathway regulator . Positive_regulation AXIN2 PLK1 16815967 1586077 High [conductin] expression compromises the spindle checkpoint , and this *requires* localized activity . Positive_regulation AXIN2 PRMT1 21242974 2425511 We found that the transient expression of *led* to an increased level of [Axin] and that knockdown of endogenous PRMT1 by short hairpin RNA reduced the level of Axin . Positive_regulation AXIN2 PRMT1 21242974 2425515 Consistent with the *role* of in the regulation of [Axin] , knockdown of PRMT1 enhanced the level of cytoplasmic ß-catenin as well as ß-catenin dependent transcription activity . Positive_regulation AXIN2 RAN 14630927 1201139 We have characterized the sequence requirement for export and identified two export domains , which do not contain classical nuclear export consensus sequences , and we show that [Axin] binds directly to the export factor CRM1 in the *presence* of . Positive_regulation AXIN2 RNF146 21799911 2461992 Ubiquitin ligase *regulates* tankyrase and [Axin] to promote Wnt signaling . Positive_regulation AXIN2 SFRP2 24336656 2921528 Gene expression analysis of the hamster heart and cultured fibroblasts identified [Axin2] as a downstream target , the expression of which was *activated* by but inhibited by therapeutic intervention . Positive_regulation AXIN2 SHH 19924825 2167106 Finally , based on partially reciprocal patterns of Wnt and Shh signals in the thalamic ventricular zone , we tested if signal is sufficient or *necessary* for the differential [Axin2] expression . Positive_regulation AXIN2 SMURF2 20858899 2342911 The protein stability of [Axin] , a negative regulator of Wnt signaling , is *regulated* by ( Smurf2 ) . Positive_regulation AXIN2 TCF12 11809808 906698 signaling *induces* the transcription of [Axin2] , a negative regulator of the signaling pathway . Positive_regulation AXIN2 TCF12 15677333 1369849 Wnt ligands bind their receptors Frizzled and low-density lipoprotein receptor related protein 5/6 and function through Disheveled (Dvl) , [Axin] , adenomatous polyposis coli , glycogen synthase kinase 3beta , and casein kinase (CK) 1 to stabilize beta-catenin and *induce* lymphocyte enhancer binding factor ( LEF ) dependent transcriptional activities . Positive_regulation AXIN2 TCF15 11809808 906699 signaling *induces* the transcription of [Axin2] , a negative regulator of the signaling pathway . Positive_regulation AXIN2 TCF15 15677333 1369850 Wnt ligands bind their receptors Frizzled and low-density lipoprotein receptor related protein 5/6 and function through Disheveled (Dvl) , [Axin] , adenomatous polyposis coli , glycogen synthase kinase 3beta , and casein kinase (CK) 1 to stabilize beta-catenin and *induce* lymphocyte enhancer binding factor ( LEF ) dependent transcriptional activities . Positive_regulation AXIN2 TCF19 11809808 906700 signaling *induces* the transcription of [Axin2] , a negative regulator of the signaling pathway . Positive_regulation AXIN2 TCF19 15677333 1369851 Wnt ligands bind their receptors Frizzled and low-density lipoprotein receptor related protein 5/6 and function through Disheveled (Dvl) , [Axin] , adenomatous polyposis coli , glycogen synthase kinase 3beta , and casein kinase (CK) 1 to stabilize beta-catenin and *induce* lymphocyte enhancer binding factor ( LEF ) dependent transcriptional activities . Positive_regulation AXIN2 TCF20 11809808 906701 signaling *induces* the transcription of [Axin2] , a negative regulator of the signaling pathway . Positive_regulation AXIN2 TCF20 15677333 1369852 Wnt ligands bind their receptors Frizzled and low-density lipoprotein receptor related protein 5/6 and function through Disheveled (Dvl) , [Axin] , adenomatous polyposis coli , glycogen synthase kinase 3beta , and casein kinase (CK) 1 to stabilize beta-catenin and *induce* lymphocyte enhancer binding factor ( LEF ) dependent transcriptional activities . Positive_regulation AXIN2 TCF21 11809808 906702 signaling *induces* the transcription of [Axin2] , a negative regulator of the signaling pathway . Positive_regulation AXIN2 TCF21 15677333 1369853 Wnt ligands bind their receptors Frizzled and low-density lipoprotein receptor related protein 5/6 and function through Disheveled (Dvl) , [Axin] , adenomatous polyposis coli , glycogen synthase kinase 3beta , and casein kinase (CK) 1 to stabilize beta-catenin and *induce* lymphocyte enhancer binding factor ( LEF ) dependent transcriptional activities . Positive_regulation AXIN2 TCF23 11809808 906713 signaling *induces* the transcription of [Axin2] , a negative regulator of the signaling pathway . Positive_regulation AXIN2 TCF23 15677333 1369857 Wnt ligands bind their receptors Frizzled and low-density lipoprotein receptor related protein 5/6 and function through Disheveled (Dvl) , [Axin] , adenomatous polyposis coli , glycogen synthase kinase 3beta , and casein kinase (CK) 1 to stabilize beta-catenin and *induce* lymphocyte enhancer binding factor ( LEF ) dependent transcriptional activities . Positive_regulation AXIN2 TCF24 11809808 906716 signaling *induces* the transcription of [Axin2] , a negative regulator of the signaling pathway . Positive_regulation AXIN2 TCF24 15677333 1369859 Wnt ligands bind their receptors Frizzled and low-density lipoprotein receptor related protein 5/6 and function through Disheveled (Dvl) , [Axin] , adenomatous polyposis coli , glycogen synthase kinase 3beta , and casein kinase (CK) 1 to stabilize beta-catenin and *induce* lymphocyte enhancer binding factor ( LEF ) dependent transcriptional activities . Positive_regulation AXIN2 TCF25 11809808 906715 signaling *induces* the transcription of [Axin2] , a negative regulator of the signaling pathway . Positive_regulation AXIN2 TCF25 15677333 1369858 Wnt ligands bind their receptors Frizzled and low-density lipoprotein receptor related protein 5/6 and function through Disheveled (Dvl) , [Axin] , adenomatous polyposis coli , glycogen synthase kinase 3beta , and casein kinase (CK) 1 to stabilize beta-catenin and *induce* lymphocyte enhancer binding factor ( LEF ) dependent transcriptional activities . Positive_regulation AXIN2 TCF3 11809808 906703 signaling *induces* the transcription of [Axin2] , a negative regulator of the signaling pathway . Positive_regulation AXIN2 TCF3 15677333 1369854 Wnt ligands bind their receptors Frizzled and low-density lipoprotein receptor related protein 5/6 and function through Disheveled (Dvl) , [Axin] , adenomatous polyposis coli , glycogen synthase kinase 3beta , and casein kinase (CK) 1 to stabilize beta-catenin and *induce* lymphocyte enhancer binding factor ( LEF ) dependent transcriptional activities . Positive_regulation AXIN2 TCF4 11809808 906704 signaling *induces* the transcription of [Axin2] , a negative regulator of the signaling pathway . Positive_regulation AXIN2 TCF4 15677333 1369855 Wnt ligands bind their receptors Frizzled and low-density lipoprotein receptor related protein 5/6 and function through Disheveled (Dvl) , [Axin] , adenomatous polyposis coli , glycogen synthase kinase 3beta , and casein kinase (CK) 1 to stabilize beta-catenin and *induce* lymphocyte enhancer binding factor ( LEF ) dependent transcriptional activities . Positive_regulation AXIN2 TCF7 11809808 906705 signaling *induces* the transcription of [Axin2] , a negative regulator of the signaling pathway . Positive_regulation AXIN2 TCF7 15677333 1369856 Wnt ligands bind their receptors Frizzled and low-density lipoprotein receptor related protein 5/6 and function through Disheveled (Dvl) , [Axin] , adenomatous polyposis coli , glycogen synthase kinase 3beta , and casein kinase (CK) 1 to stabilize beta-catenin and *induce* lymphocyte enhancer binding factor ( LEF ) dependent transcriptional activities . Positive_regulation AXIN2 TGFB1 16909103 1692101 Also , *induced* [gammaH2AX in] an ROS dependent manner similar to bystander foci . Positive_regulation AXIN2 USP34 21383061 2420861 The ubiquitin-specific protease *regulates* [axin] stability and Wnt/ß-catenin signaling . Positive_regulation AXIN2 WNT1 10906131 743659 In L cells where APC is intact , Axin ( delta ) ( beta)(-catenin ) inhibited *dependent* accumulation of beta-catenin but not [Axin-] ( 298-832 ) ( delta ) ( beta)(-catenin ) in which the APC- and beta-catenin binding sites are deleted . Positive_regulation AXIN2 WNT1 11486025 845081 Four mechanisms are known to cause increases in beta-catenin : mutations of beta-catenin , adenomatous polyposis coli , or [axin] genes and *activation* of signaling . Positive_regulation AXIN2 WNT1 11809808 906706 signaling *induces* the transcription of [Axin2] , a negative regulator of the signaling pathway . Positive_regulation AXIN2 WNT1 11809808 906724 Because many sites of Axin2 expression overlapped with those of several Wnt genes , we tested whether [Axin2] was *induced* by signaling . Positive_regulation AXIN2 WNT1 11809809 906831 In time course experiments , stabilization of beta-catenin *preceded* the upregulation of [conductin] by . Positive_regulation AXIN2 WNT1 15899843 1408787 The lack of redundancy between Axin and Axin2 could be due to their different modes of expression : while Axin is expressed ubiquitously , [Axin2] is expressed in tissue- and developmental-stage-specific patterns , and its transcription is *induced* by canonical signaling . Positive_regulation AXIN2 WNT1 16303557 1485429 Finally , we demonstrate an association of Galpha ( o ) with Fz that is also very rapidly ( t1/2 < 1 min ) perturbed upon Wnt-3a stimulation and that the *dependent* effects on both [GSK3beta/Axin2] and Galpha ( o ) /Fz are pertussis-toxin sensitive . Positive_regulation AXIN2 WNT1 21304492 2414722 Knockdown of Amer1 reduces *induced* LRP6 phosphorylation , [Axin] translocation to the plasma membrane and formation of LRP6 signalosomes . Positive_regulation AXIN2 WNT1 21498506 2434717 Amer1 stabilizes Axin and counteracts *induced* degradation of [Axin] , which requires membrane localization of Amer1 . Positive_regulation AXIN2 WNT1 22589174 2669468 Moreover , knockdown of LRP8 resulted in a decrease in ß-catenin levels and suppression of *induced* [Axin2] transcription . Positive_regulation AXIN2 WNT1 23409032 2743948 Accordingly , we observed a decrease in *dependent* luciferase reporter activity as well as a decreased expression of [AXIN2] representing an endogenous ß-catenin target gene . Positive_regulation AXIN2 WNT1 23579495 2783450 Formation of the *induced* [LRP6-Axin] signaling complex promoted Axin dephosphorylation by protein phosphatase-1 and inactivated ( `` closed '' ) Axin through an intramolecular interaction . Positive_regulation AXIN2 WNT1 24401947 2907006 The K345Q mutation in ß-catenin inhibited *induced* cell growth and [axin2/TCF7] upregulation in breast cancer cells . Positive_regulation AXIN2 WNT11 10906131 743660 In L cells where APC is intact , Axin ( delta ) ( beta)(-catenin ) inhibited *dependent* accumulation of beta-catenin but not [Axin-] ( 298-832 ) ( delta ) ( beta)(-catenin ) in which the APC- and beta-catenin binding sites are deleted . Positive_regulation AXIN2 WNT11 11486025 845082 Four mechanisms are known to cause increases in beta-catenin : mutations of beta-catenin , adenomatous polyposis coli , or [axin] genes and *activation* of signaling . Positive_regulation AXIN2 WNT11 11809808 906707 signaling *induces* the transcription of [Axin2] , a negative regulator of the signaling pathway . Positive_regulation AXIN2 WNT11 11809808 906725 Because many sites of Axin2 expression overlapped with those of several Wnt genes , we tested whether [Axin2] was *induced* by signaling . Positive_regulation AXIN2 WNT11 15899843 1408788 The lack of redundancy between Axin and Axin2 could be due to their different modes of expression : while Axin is expressed ubiquitously , [Axin2] is expressed in tissue- and developmental-stage-specific patterns , and its transcription is *induced* by canonical signaling . Positive_regulation AXIN2 WNT11 16303557 1485430 Finally , we demonstrate an association of Galpha ( o ) with Fz that is also very rapidly ( t1/2 < 1 min ) perturbed upon Wnt-3a stimulation and that the *dependent* effects on both [GSK3beta/Axin2] and Galpha ( o ) /Fz are pertussis-toxin sensitive . Positive_regulation AXIN2 WNT11 17202189 1680723 In the full-grown oocyte , before maturation , we find that [axin] levels are also *regulated* by and LRP6 . Positive_regulation AXIN2 WNT11 17202189 1680733 In the oocyte , and/or LRP6 *regulates* [axin] to maintain beta-catenin at a low level , while in the embryo , asymmetrical Wnt11/LRP6 signaling stabilizes beta-catenin and enriches it on the dorsal side . Positive_regulation AXIN2 WNT11 21304492 2414723 Knockdown of Amer1 reduces *induced* LRP6 phosphorylation , [Axin] translocation to the plasma membrane and formation of LRP6 signalosomes . Positive_regulation AXIN2 WNT11 21498506 2434718 Amer1 stabilizes Axin and counteracts *induced* degradation of [Axin] , which requires membrane localization of Amer1 . Positive_regulation AXIN2 WNT11 22589174 2669469 Moreover , knockdown of LRP8 resulted in a decrease in ß-catenin levels and suppression of *induced* [Axin2] transcription . Positive_regulation AXIN2 WNT11 23409032 2743949 Accordingly , we observed a decrease in *dependent* luciferase reporter activity as well as a decreased expression of [AXIN2] representing an endogenous ß-catenin target gene . Positive_regulation AXIN2 WNT11 23579495 2783451 Formation of the *induced* [LRP6-Axin] signaling complex promoted Axin dephosphorylation by protein phosphatase-1 and inactivated ( `` closed '' ) Axin through an intramolecular interaction . Positive_regulation AXIN2 WNT11 24401947 2907007 The K345Q mutation in ß-catenin inhibited *induced* cell growth and [axin2/TCF7] upregulation in breast cancer cells . Positive_regulation AXIN2 WNT16 10906131 743665 In L cells where APC is intact , Axin ( delta ) ( beta)(-catenin ) inhibited *dependent* accumulation of beta-catenin but not [Axin-] ( 298-832 ) ( delta ) ( beta)(-catenin ) in which the APC- and beta-catenin binding sites are deleted . Positive_regulation AXIN2 WNT16 11486025 845087 Four mechanisms are known to cause increases in beta-catenin : mutations of beta-catenin , adenomatous polyposis coli , or [axin] genes and *activation* of signaling . Positive_regulation AXIN2 WNT16 11809808 906712 signaling *induces* the transcription of [Axin2] , a negative regulator of the signaling pathway . Positive_regulation AXIN2 WNT16 11809808 906730 Because many sites of Axin2 expression overlapped with those of several Wnt genes , we tested whether [Axin2] was *induced* by signaling . Positive_regulation AXIN2 WNT16 15899843 1408793 The lack of redundancy between Axin and Axin2 could be due to their different modes of expression : while Axin is expressed ubiquitously , [Axin2] is expressed in tissue- and developmental-stage-specific patterns , and its transcription is *induced* by canonical signaling . Positive_regulation AXIN2 WNT16 16303557 1485435 Finally , we demonstrate an association of Galpha ( o ) with Fz that is also very rapidly ( t1/2 < 1 min ) perturbed upon Wnt-3a stimulation and that the *dependent* effects on both [GSK3beta/Axin2] and Galpha ( o ) /Fz are pertussis-toxin sensitive . Positive_regulation AXIN2 WNT16 21304492 2414728 Knockdown of Amer1 reduces *induced* LRP6 phosphorylation , [Axin] translocation to the plasma membrane and formation of LRP6 signalosomes . Positive_regulation AXIN2 WNT16 21498506 2434723 Amer1 stabilizes Axin and counteracts *induced* degradation of [Axin] , which requires membrane localization of Amer1 . Positive_regulation AXIN2 WNT16 22589174 2669474 Moreover , knockdown of LRP8 resulted in a decrease in ß-catenin levels and suppression of *induced* [Axin2] transcription . Positive_regulation AXIN2 WNT16 23409032 2743954 Accordingly , we observed a decrease in *dependent* luciferase reporter activity as well as a decreased expression of [AXIN2] representing an endogenous ß-catenin target gene . Positive_regulation AXIN2 WNT16 23579495 2783456 Formation of the *induced* [LRP6-Axin] signaling complex promoted Axin dephosphorylation by protein phosphatase-1 and inactivated ( `` closed '' ) Axin through an intramolecular interaction . Positive_regulation AXIN2 WNT16 24401947 2907012 The K345Q mutation in ß-catenin inhibited *induced* cell growth and [axin2/TCF7] upregulation in breast cancer cells . Positive_regulation AXIN2 WNT2 10906131 743661 In L cells where APC is intact , Axin ( delta ) ( beta)(-catenin ) inhibited *dependent* accumulation of beta-catenin but not [Axin-] ( 298-832 ) ( delta ) ( beta)(-catenin ) in which the APC- and beta-catenin binding sites are deleted . Positive_regulation AXIN2 WNT2 11486025 845083 Four mechanisms are known to cause increases in beta-catenin : mutations of beta-catenin , adenomatous polyposis coli , or [axin] genes and *activation* of signaling . Positive_regulation AXIN2 WNT2 11809808 906708 signaling *induces* the transcription of [Axin2] , a negative regulator of the signaling pathway . Positive_regulation AXIN2 WNT2 11809808 906726 Because many sites of Axin2 expression overlapped with those of several Wnt genes , we tested whether [Axin2] was *induced* by signaling . Positive_regulation AXIN2 WNT2 15899843 1408789 The lack of redundancy between Axin and Axin2 could be due to their different modes of expression : while Axin is expressed ubiquitously , [Axin2] is expressed in tissue- and developmental-stage-specific patterns , and its transcription is *induced* by canonical signaling . Positive_regulation AXIN2 WNT2 16303557 1485431 Finally , we demonstrate an association of Galpha ( o ) with Fz that is also very rapidly ( t1/2 < 1 min ) perturbed upon Wnt-3a stimulation and that the *dependent* effects on both [GSK3beta/Axin2] and Galpha ( o ) /Fz are pertussis-toxin sensitive . Positive_regulation AXIN2 WNT2 21304492 2414724 Knockdown of Amer1 reduces *induced* LRP6 phosphorylation , [Axin] translocation to the plasma membrane and formation of LRP6 signalosomes . Positive_regulation AXIN2 WNT2 21498506 2434719 Amer1 stabilizes Axin and counteracts *induced* degradation of [Axin] , which requires membrane localization of Amer1 . Positive_regulation AXIN2 WNT2 22589174 2669470 Moreover , knockdown of LRP8 resulted in a decrease in ß-catenin levels and suppression of *induced* [Axin2] transcription . Positive_regulation AXIN2 WNT2 23409032 2743950 Accordingly , we observed a decrease in *dependent* luciferase reporter activity as well as a decreased expression of [AXIN2] representing an endogenous ß-catenin target gene . Positive_regulation AXIN2 WNT2 23579495 2783452 Formation of the *induced* [LRP6-Axin] signaling complex promoted Axin dephosphorylation by protein phosphatase-1 and inactivated ( `` closed '' ) Axin through an intramolecular interaction . Positive_regulation AXIN2 WNT2 24401947 2907008 The K345Q mutation in ß-catenin inhibited *induced* cell growth and [axin2/TCF7] upregulation in breast cancer cells . Positive_regulation AXIN2 WNT3 10906131 743662 In L cells where APC is intact , Axin ( delta ) ( beta)(-catenin ) inhibited *dependent* accumulation of beta-catenin but not [Axin-] ( 298-832 ) ( delta ) ( beta)(-catenin ) in which the APC- and beta-catenin binding sites are deleted . Positive_regulation AXIN2 WNT3 11486025 845084 Four mechanisms are known to cause increases in beta-catenin : mutations of beta-catenin , adenomatous polyposis coli , or [axin] genes and *activation* of signaling . Positive_regulation AXIN2 WNT3 11809808 906709 signaling *induces* the transcription of [Axin2] , a negative regulator of the signaling pathway . Positive_regulation AXIN2 WNT3 11809808 906727 Because many sites of Axin2 expression overlapped with those of several Wnt genes , we tested whether [Axin2] was *induced* by signaling . Positive_regulation AXIN2 WNT3 15899843 1408790 The lack of redundancy between Axin and Axin2 could be due to their different modes of expression : while Axin is expressed ubiquitously , [Axin2] is expressed in tissue- and developmental-stage-specific patterns , and its transcription is *induced* by canonical signaling . Positive_regulation AXIN2 WNT3 16303557 1485432 Finally , we demonstrate an association of Galpha ( o ) with Fz that is also very rapidly ( t1/2 < 1 min ) perturbed upon Wnt-3a stimulation and that the *dependent* effects on both [GSK3beta/Axin2] and Galpha ( o ) /Fz are pertussis-toxin sensitive . Positive_regulation AXIN2 WNT3 21304492 2414725 Knockdown of Amer1 reduces *induced* LRP6 phosphorylation , [Axin] translocation to the plasma membrane and formation of LRP6 signalosomes . Positive_regulation AXIN2 WNT3 21498506 2434720 Amer1 stabilizes Axin and counteracts *induced* degradation of [Axin] , which requires membrane localization of Amer1 . Positive_regulation AXIN2 WNT3 22589174 2669471 Moreover , knockdown of LRP8 resulted in a decrease in ß-catenin levels and suppression of *induced* [Axin2] transcription . Positive_regulation AXIN2 WNT3 23409032 2743951 Accordingly , we observed a decrease in *dependent* luciferase reporter activity as well as a decreased expression of [AXIN2] representing an endogenous ß-catenin target gene . Positive_regulation AXIN2 WNT3 23579495 2783453 Formation of the *induced* [LRP6-Axin] signaling complex promoted Axin dephosphorylation by protein phosphatase-1 and inactivated ( `` closed '' ) Axin through an intramolecular interaction . Positive_regulation AXIN2 WNT3 24401947 2907009 The K345Q mutation in ß-catenin inhibited *induced* cell growth and [axin2/TCF7] upregulation in breast cancer cells . Positive_regulation AXIN2 WNT3A 10023673 590702 These results suggest that [Axin] forms a complex with GSK-3beta , beta-catenin , and APC , resulting in the stimulation of the degradation of beta-catenin and that *induces* the dissociation of beta-catenin from the Axin complex and accumulates beta-catenin . Positive_regulation AXIN2 WNT3A 18083923 1834560 Here we show that while *stimulates* [Axin2] in a negative feedback loop , TGF-beta suppresses the expression of both Axin1 and Axin2 and stimulates beta-catenin signaling . Positive_regulation AXIN2 WNT3A 19464575 2084977 PCB 153 reduced basal Axin2 mRNA levels and it inhibited *induction* of [Axin2] expression by recombinant mouse . Positive_regulation AXIN2 WNT3A 22748080 2709981 These data demonstrate that activation of the canonical pathway *requires* specific phosphorylation events as well as [Axin] to assemble very large , Dvl3 based supermolecular complexes ; Positive_regulation AXIN2 WNT3A 22956608 2684012 A TCF/LEF luciferase assay was used to study functional canonical Wnt signaling , which was confirmed further by *induced* expression of a pathway target gene , [AXIN2] , via quantitative PCR . Positive_regulation AXIN2 WNT4 10906131 743663 In L cells where APC is intact , Axin ( delta ) ( beta)(-catenin ) inhibited *dependent* accumulation of beta-catenin but not [Axin-] ( 298-832 ) ( delta ) ( beta)(-catenin ) in which the APC- and beta-catenin binding sites are deleted . Positive_regulation AXIN2 WNT4 11486025 845085 Four mechanisms are known to cause increases in beta-catenin : mutations of beta-catenin , adenomatous polyposis coli , or [axin] genes and *activation* of signaling . Positive_regulation AXIN2 WNT4 11809808 906710 signaling *induces* the transcription of [Axin2] , a negative regulator of the signaling pathway . Positive_regulation AXIN2 WNT4 11809808 906728 Because many sites of Axin2 expression overlapped with those of several Wnt genes , we tested whether [Axin2] was *induced* by signaling . Positive_regulation AXIN2 WNT4 15899843 1408791 The lack of redundancy between Axin and Axin2 could be due to their different modes of expression : while Axin is expressed ubiquitously , [Axin2] is expressed in tissue- and developmental-stage-specific patterns , and its transcription is *induced* by canonical signaling . Positive_regulation AXIN2 WNT4 16303557 1485433 Finally , we demonstrate an association of Galpha ( o ) with Fz that is also very rapidly ( t1/2 < 1 min ) perturbed upon Wnt-3a stimulation and that the *dependent* effects on both [GSK3beta/Axin2] and Galpha ( o ) /Fz are pertussis-toxin sensitive . Positive_regulation AXIN2 WNT4 21304492 2414726 Knockdown of Amer1 reduces *induced* LRP6 phosphorylation , [Axin] translocation to the plasma membrane and formation of LRP6 signalosomes . Positive_regulation AXIN2 WNT4 21498506 2434721 Amer1 stabilizes Axin and counteracts *induced* degradation of [Axin] , which requires membrane localization of Amer1 . Positive_regulation AXIN2 WNT4 22589174 2669472 Moreover , knockdown of LRP8 resulted in a decrease in ß-catenin levels and suppression of *induced* [Axin2] transcription . Positive_regulation AXIN2 WNT4 23409032 2743952 Accordingly , we observed a decrease in *dependent* luciferase reporter activity as well as a decreased expression of [AXIN2] representing an endogenous ß-catenin target gene . Positive_regulation AXIN2 WNT4 23579495 2783454 Formation of the *induced* [LRP6-Axin] signaling complex promoted Axin dephosphorylation by protein phosphatase-1 and inactivated ( `` closed '' ) Axin through an intramolecular interaction . Positive_regulation AXIN2 WNT4 24401947 2907010 The K345Q mutation in ß-catenin inhibited *induced* cell growth and [axin2/TCF7] upregulation in breast cancer cells . Positive_regulation AXIN2 WNT5A 17646398 1775802 Using monolayers of primary rodent embryo fibroblasts , we show here that dishevelled (Dvl) and [axin] , two major components of the Wnt signaling pathway are required for centrosome reorientation and that is *required* for activation of this pathway . Positive_regulation AXIN2 WNT6 10906131 743664 In L cells where APC is intact , Axin ( delta ) ( beta)(-catenin ) inhibited *dependent* accumulation of beta-catenin but not [Axin-] ( 298-832 ) ( delta ) ( beta)(-catenin ) in which the APC- and beta-catenin binding sites are deleted . Positive_regulation AXIN2 WNT6 11486025 845086 Four mechanisms are known to cause increases in beta-catenin : mutations of beta-catenin , adenomatous polyposis coli , or [axin] genes and *activation* of signaling . Positive_regulation AXIN2 WNT6 11809808 906711 signaling *induces* the transcription of [Axin2] , a negative regulator of the signaling pathway . Positive_regulation AXIN2 WNT6 11809808 906729 Because many sites of Axin2 expression overlapped with those of several Wnt genes , we tested whether [Axin2] was *induced* by signaling . Positive_regulation AXIN2 WNT6 15899843 1408792 The lack of redundancy between Axin and Axin2 could be due to their different modes of expression : while Axin is expressed ubiquitously , [Axin2] is expressed in tissue- and developmental-stage-specific patterns , and its transcription is *induced* by canonical signaling . Positive_regulation AXIN2 WNT6 16303557 1485434 Finally , we demonstrate an association of Galpha ( o ) with Fz that is also very rapidly ( t1/2 < 1 min ) perturbed upon Wnt-3a stimulation and that the *dependent* effects on both [GSK3beta/Axin2] and Galpha ( o ) /Fz are pertussis-toxin sensitive . Positive_regulation AXIN2 WNT6 21304492 2414727 Knockdown of Amer1 reduces *induced* LRP6 phosphorylation , [Axin] translocation to the plasma membrane and formation of LRP6 signalosomes . Positive_regulation AXIN2 WNT6 21498506 2434722 Amer1 stabilizes Axin and counteracts *induced* degradation of [Axin] , which requires membrane localization of Amer1 . Positive_regulation AXIN2 WNT6 22589174 2669473 Moreover , knockdown of LRP8 resulted in a decrease in ß-catenin levels and suppression of *induced* [Axin2] transcription . Positive_regulation AXIN2 WNT6 23409032 2743953 Accordingly , we observed a decrease in *dependent* luciferase reporter activity as well as a decreased expression of [AXIN2] representing an endogenous ß-catenin target gene . Positive_regulation AXIN2 WNT6 23579495 2783455 Formation of the *induced* [LRP6-Axin] signaling complex promoted Axin dephosphorylation by protein phosphatase-1 and inactivated ( `` closed '' ) Axin through an intramolecular interaction . Positive_regulation AXIN2 WNT6 24401947 2907011 The K345Q mutation in ß-catenin inhibited *induced* cell growth and [axin2/TCF7] upregulation in breast cancer cells . Positive_regulation AZIN1 TNF 21791562 2467555 In situ hybridization analysis has confirmed the differential expression of three of these genes , namely *induced* protein 6 , gonadotropin-inducible transcription factor 1 , and ornithine decarboxylase [antizyme inhibitor 1] . Positive_regulation B2M CD14 24383466 2911963 Decidual ( + ) DC-SIGN ( + ) antigen presenting cells (APCs) *enhance* the [HLA-G] expression of cocultured CD4 ( + ) naïve T cells in vitro . Positive_regulation B2M TNF 1697308 139520 but not IL-1 also *increases* [class I MHC] Ag expression . Positive_regulation B2M TNF 2105059 126873 Finally , *induced* [class I MHC] expression was inhibited strongly by IL-1 alpha . Positive_regulation B2M TNF 3123068 90264 in combination with IFN-gamma *enhances* HUVEC expression of HLA-alpha , [B2m] , and HLA-DQ greater than that observed with either mediator alone . Positive_regulation B2M TNF 3141300 99685 The surface expression of HLA-ABC ( class I ) antigens and [beta 2-microglobulin] , was significantly *enhanced* by alone on every cell line and clone tested . Positive_regulation B3GALT4 TNF 15668227 1388266 *caused* a rapid increase in the activity of [GalT-2] and synthesis of LacCer . Positive_regulation B3GALT4 TNF 15668227 1388268 LY294002 also inhibited induced [GalT-2] *activation* and LacCer synthesis , suggesting a phosphatidylinositol 3-kinase mediated regulation of GalT-2 . Positive_regulation B3GALT4 TNF 16100442 1444106 *enhanced* CGT , [GalT2] and GalT6 mRNA levels and EGCG suppressed the level of these enzymes enhanced by TNF-alpha treatment . Positive_regulation B3GAT1 EPHB2 11784793 901083 MAP kinase activation in superficial spinal cord neurons *induces* prodynorphin and [NK-1] upregulation and contributes to persistent inflammatory pain hypersensitivity . Positive_regulation B3GAT3 IL1B 11801247 902523 We recently reported that glucosamine reversed the decrease in proteoglycan synthesis and in [UDP-glucuronosyltransferase I] mRNA expression *induced* by [ Arthritis Rheum. 44 ( 2001 ) 351-360 ] . Positive_regulation B4GALT1 TNF 15668241 1382115 Our data show that *induced* an increase in the expression of [beta1,4-galactosyltransferase-1] ( beta4GalT-1 ) in primary human umbilical vein endothelial cells in a time- and concentration dependent manner . Positive_regulation B4GALT1 TNF 17917074 1804096 The *role* of and its receptors in the production of [beta-1,4 galactosyltransferase I] and V mRNAs by rat primary astrocytes . Positive_regulation B9D2 STK39 18083840 1837182 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation BAAT GMPR 9813009 546025 Rat is 96 % identical to human GMP-r , and its mRNA is *increased* 30-fold in [BAT] within 6 h of cold exposure . Positive_regulation BACE1 PCSK9 20453200 2300986 is not *involved* in the degradation of LDL receptors and [BACE1] in the adult mouse brain . Positive_regulation BACE1 PCSK9 20453200 2300991 In addition , we found no evidence that *regulates* [BACE1] levels or APP processing in the mouse brain . Positive_regulation BACE1 PGC 23312803 2752802 In this study we tested the hypothesis that NR treatment in an AD mouse model could attenuate Aß toxicity through the activation of *mediated* [BACE1] degradation . Positive_regulation BACE1 PGC 23312803 2752803 Our studies suggest that dietary treatment with NR might benefit AD cognitive function and synaptic plasticity , in part by promoting *mediated* [BACE1] ubiquitination and degradation , thus preventing Aß production in the brain . Positive_regulation BACE1 TNF 17255335 1691101 directly *stimulated* [beta-site APP cleaving enzyme] ( BACE1 ) expression and enhanced beta processing of APP in astrocytes . Positive_regulation BACE1 TNF 22047170 2508334 stimulation significantly *increased* levels of astrocytic [BACE1] , APP , and secreted Aß40 . Positive_regulation BAD IRS4 10594015 654763 also *promoted* the activation of PKB/Akt and [BAD] phosphorylation during insulin stimulation ; Positive_regulation BAD MAP2K6 15121878 1258536 Chemical inhibition of PI-3K and 1 *inhibited* E ( 2 ) -induced [BAD] phosphorylation at S112 and S136 and expression of dominant negative Ras induced apoptosis in proliferating cells . Positive_regulation BAD TNF 10383455 624600 *induced* the phosphorylation of [BAD] at serine 136 in HeLa cells under conditions that are not cytotoxic . Positive_regulation BAD TNF 12748063 1119607 Additionally , ethanol exposed cells display a blunting of *induced* Akt activation and [Bcl-2 antagonist of cell death] phosphorylation that may account , in part , for the increased sensitivity of the mitochondria to Bax mediated damage . Positive_regulation BAI1 EPHB2 21415537 2405506 These results suggest that [Bai] produce an antidepressant-like effect and this effect is at least partly *mediated* by hippocampal mediated neurotrophic action . Positive_regulation BAI2 EPHB2 21415537 2405507 These results suggest that [Bai] produce an antidepressant-like effect and this effect is at least partly *mediated* by hippocampal mediated neurotrophic action . Positive_regulation BAI3 EPHB2 21415537 2405508 These results suggest that [Bai] produce an antidepressant-like effect and this effect is at least partly *mediated* by hippocampal mediated neurotrophic action . Positive_regulation BAMBI TNF 24448807 2932994 ChIP analysis revealed that LPS and *induced* binding of the NF-?Bp50/p50 homodimer to the [BAMBI] promoter region . Positive_regulation BANF1 NT5E 7759602 307827 Present results suggest that NGF , NT-3 and may *act* in [PIC] and indirectly in lymphocytes , whereas BDNF and NT-4/5 could control macrophages . Positive_regulation BANP TNF 20006573 2199868 Further , we show that stimulation *induces* [SMAR1] phosphorylation at Ser-347 and promotes its cytoplasmic translocation , thus releasing its negative effect . Positive_regulation BARD1 FAS 18514188 1922501 Genistein inhibits estrogen receptor-alpha and activates [BARD1] in BRCA1 blocked cells and *induces* estrogen receptor-beta and in presence of BRCA1 . Positive_regulation BAX ABCG2 21161336 2402061 These changes were associated with down-regulation of the membrane transporter and attenuation of EGFR , IGF-1R , and NF-?B signaling consistent with inactivation of ß-catenin , COX-2 , c-Myc and Bcl-xL and *activation* of the pro-apoptotic [Bax] . Positive_regulation BAX CAPN8 11413236 828683 Cleavage of [Bax] is *mediated* by caspase dependent or -independent activation in dopaminergic neuronal cells : protective role of Bcl-2 . Positive_regulation BAX CAPN8 11413236 828892 This proteolytic cleavage of [Bax] appeared to be *mediated* by as determined by incubation with [ ( 35 ) S ] methionine labelled Bax . Positive_regulation BAX CAPN8 14612448 1200508 Pharmacological inhibition during spontaneous and Fas receptor induced neutrophil apoptosis *prevented* cleavage of [Bax] into an 18-kDa fragment unable to interact with Bcl-xL . Positive_regulation BAX CAPN8 16214879 1508054 U-46619 induced activation *resulted* in translocation of [Bax] to the mitochondria , loss of polarization of the latter ( using potentiometric probe 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolyl-carbocyanine iodide ; Positive_regulation BAX CAPN8 19894226 2188755 Other events in apoptosis included overexpression of [Bax] , loss of DeltaPsi ( m ) , mitochondrial release of cytochrome c and Smac into the cytosol , down-regulation of baculoviral inhibitor-of-apoptosis repeat containing proteins , and *activation* of , caspase-9 , and caspase-3 . Positive_regulation BAX CAPN8 20406947 2256168 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , caspase dependent amplification of mitochondrial depolarization , *activation* of , and [Bax] cleavage . Positive_regulation BAX CAPN8 22418443 2588014 Together , these results demonstrate that PDT with a chlorin based photosensitizer targets TG2 by activating *induced* [Bax] translocation , which induces apoptotic cell death through both caspase dependent and AIF mediated pathways . Positive_regulation BAX CCND1 18386789 1893162 Proliferating cell nuclear antigen ( PCNA ) , and Bcl-2 expression decreased , and [Bax] expression and nuclear fragmentation *increased* with increasing dietary beta-ionone . Positive_regulation BAX CCND1 9568392 501305 When neurons are deprived of trophic factors , a sequence of events is initiated , which includes a reduction in macromolecule synthesis , elevation of c-Jun and , and *activation* of [BAX] . Positive_regulation BAX EPHB2 17675494 1777340 however , Bcl-2 augmentation but not [Bax] translocation is *dependent* on Ca ( 2+ ) increase , activation of protein kinase C , and phosphorylation . Positive_regulation BAX EPHB2 21078664 2371610 Overall , our results indicate that nimbolide can sensitize colon cancer cells to TRAIL induced apoptosis through three distinct mechanisms : reactive oxygen species- and *mediated* up-regulation of DR5 and DR4 , down-regulation of cell survival proteins , and up-regulation of p53 and [Bax] . Positive_regulation BAX EPHB2 23732112 2811877 The disruption of mitochondrial outer membrane permeabilisation , the activation of caspase-3/7 and 9 , the downregulation of Bcl-2 , the upregulation of [Bax] , and the *activation* of p38 MAPK , and NF-?B were all observed in HIV-1 Tat treated RPE cells . Positive_regulation BAX FAS 10200513 561125 The [Bax] gene was activated in irradiated and ara-C treated BV173 cells , but was *induced* only in irradiated BV173 cells . Positive_regulation BAX FAS 10751382 698699 Bcl-2 inhibits a *induced* conformational change in the Bax N terminus and [Bax] mitochondrial translocation . Positive_regulation BAX FAS 11774740 890603 A [Bax] *induces* apoptosis mitochondria-dependently , whereas can induce apoptosis mitochondria-independently . Positive_regulation BAX FAS 12714376 1140835 Using RNase protection assays , we showed that IL-6 enhanced *induced* apoptosis and expression of [Bax] in normal-Fb , but inhibited apoptosis and induced expression of Bcl-2 in IPF-Fb . Positive_regulation BAX FAS 18373696 1898903 These results indicate that the JNK-c-Jun pathway is required for the transcriptional upregulation of and subsequent *activation* of [Bax] and Bak , and that JNK , but not c-Jun , is directly associated with phosphorylation and downregulation of Bcl-2 in response to ionizing radiation . Positive_regulation BAX FAS 9163609 432094 In conclusion , our results suggest a p53 independent co-regulation of and Bax , as well as a *role* for [Bax] in Apo-1/Fas induced apoptosis in myeloma . Positive_regulation BAX ID1 18158619 1971442 *regulates* Bcl-2 and [Bax] expression through p53 and NF-kappaB in MCF-7 breast cancer cells . Positive_regulation BAX ID1 18158619 1971456 expression *resulted* in increased number of viable cells , reduced [Bax] expression , enhanced Bcl-2 expression , but no change in Bcl-xL expression . Positive_regulation BAX ID1 20945346 2389306 *regulated* the expression levels of anti-apoptotic Bcl-2 and pro-apoptotic [Bax] , and resulted in delay of apoptotic peak during postlactational involution . Positive_regulation BAX IFI27 18330707 1886398 *enhanced* etoposide induced cytochrome c release , [Bax] activation and loss of mitochondrial membrane potential . Positive_regulation BAX IL1B 19217321 2086498 The *induced* expressions of DKK1 , [Bax] , Bad and caspase-3 dependent apoptosis of chondrocyte cultures . Positive_regulation BAX IL1B 20541824 2301949 The expression of iNOS and the promoting apoptosis gene [Bax] and Fas were significantly *up-regulated* by the induction of and TNF-alpha . Positive_regulation BAX LBP 19735167 2134514 The ratio of Bcl-2/Bax protein expression following LBP treatments decreased significantly with a dose-effect relationship , which suggested that can *regulate* the expression of Bcl-2 and [Bax] to induce apoptosis of PC-3 and DU-145 cells . Positive_regulation BAX LBP 24595452 2920504 at the dose of 40 mg/kg significantly *suppressed* overexpression of [Bax] , CytC , Caspase-3 , -9 and cleaved PARP-1 , and inhibited the reduction of Bcl-2 expression . Positive_regulation BAX MAP2K6 11842081 929179 In contrast , both U0126 , a MEK inhibitor , and active *had* little effect on [Bax] localization . Positive_regulation BAX MAP2K6 16013042 1447426 Cisplatin induced an increase in [Bax] expression , mitochondrial membrane depolarization , mitochondrial cytochrome c release and caspase-3 activation , and these changes were *prevented* by the inhibitor . Positive_regulation BAX TF 22661889 2610887 Compared to mPEG2000-DSPE liposomes , TPGS liposomes improved the cytotoxicity of emodin on leukemia cells by regulating the protein levels of myeloid cell leukemia 1 (Mcl-1) , B-cell lymphoma-2 (Bcl-2) and [Bcl-2 associated X protein] , which was further *enhanced* by . Positive_regulation BAX TNF 10949027 723247 Rather , *induced* a tBid dependent conformational change in [Bax] that allowed an interaction between E1B 19K and conformationally altered Bax , which caused inhibition of cytochrome c release and caspase-9 activation . Positive_regulation BAX TNF 11462023 839139 TNF-alpha and truncated Bid induced Bax-Bax cross linking , indicative of oligomerization , and E1B 19K expression during infection inhibited this *mediated* [Bax] oligomerization . Positive_regulation BAX TNF 11571294 882324 *induces* [Bax-Bak] interaction and apoptosis , which is inhibited by adenovirus E1B 19K . Positive_regulation BAX TNF 11571294 882332 *induces* E1B [19K-Bax] interaction and inhibits Bax oligomerization . Positive_regulation BAX TNF 11571294 882333 signaling *induced* [Bak-Bax] interaction and both Bak and Bax oligomerization . Positive_regulation BAX TNF 11600573 870742 IL-1beta , interferon gamma , and *caused* no major change in either islet cell survival or Bcl-2 and [Bax] mRNA expression after a 12-h incubation ; Positive_regulation BAX TNF 15117824 1258500 We further show that a JNK-specific inhibitor SP600125 completely blocks *induced* JNK activation , Bid cleavage , and [Bax] mitochondrial translocation , but only partially inhibits cytochrome c release and EC death , suggesting that TNF induces both JNK dependent and JNK independent apoptotic pathways in EC . Positive_regulation BAX TNF 15516208 1374775 A mitochondrial pool of sphingomyelin is involved in *induced* [Bax] translocation to mitochondria . Positive_regulation BAX TNF 16243830 1471168 Further investigation showed that silencing of hPEBP4 in MCF-7 cells promoted *induced* stability of p53 , up-regulation of phospho-p53ser15 , p21waf/cip , and [Bax] , and down-regulation of Bcl-2 and Bcl-xL , which were shown to depend on extracellular signal regulated kinase 1/2 and c-jun NH2-terminal kinase activation by hPEBP4 silencing . Positive_regulation BAX TNF 16418768 1495058 In addition , z-VAD-fmk plus *increased* [Bax] expression without affecting Bcl-2 and cytochrome expression . Positive_regulation BAX TNF 17047195 1635911 In both fibroblasts and human cancer cells subjected to cell death stimuli , inhibition of oxidative phosphorylation by use of antimycin A or oligomycin prevented ER stress- , DNA damage- , and *induced* [Bax] and Bak activation and cell death ( UV-induced Rat-1 cell death at 15 hours : control , mean = 33.6 % , 95 % confidence interval [ CI] = 18.8 % to 48.4 % ; antimycin A , mean = 10.0 % , 95 % CI = 0 % to 21.7 % ; oligomycin , mean = 13.1 % , 95 % CI = 5.7 % to 20.5 % ; tunicamycin induced MCF-7 cell death at 9 hours : control , mean = 29.2 % , 95 % CI = 21.6 % to 36.8 % ; antimycin A , mean = 15.3 % , 95 % CI = 0.8 % to 29.8 % ; oligomycin , mean = 11.5 % , 95 % CI = 3.9 % to 19.1 % ; Positive_regulation BAX TNF 17577243 1767986 The downstream events of IGF-1 triggered survival signals included phosphorylation of BAD , blockade of *induced* translocation of [Bax] from the cytosol to the mitochondrial membrane , and suppression of caspase-9 and caspase-3 activation . Positive_regulation BAX TNF 17635674 1798717 However , both cocaine and independently *increased* phospho-c-Jun NH ( 2 ) -terminal kinase and [Bax] levels at concurrent time periods ( 30 min and 1 h ) , and this elevation was attenuated in the presence of nTNF-alpha . Positive_regulation BAX TNF 17906102 1830128 The antioxidant Trolox modulated *induced* changes in [Bax/Bcl-xl] , cell injury , and MAPKs . Positive_regulation BAX TNF 18338637 1840183 [ Effect of Bax translocation on *induced* apoptosis of human breast cancer MCF7 cells stably expressed [hGFP-Bax] ] . Positive_regulation BAX TNF 18838114 1988245 DXMb protects the organ of Corti against TNFalpha ototoxicity by up-regulating Bcl-2 and Bcl-xl expression and by inhibiting *induced* increases in [Bax] , TNFR1 , and the Bax/Bcl-2 ratio . Positive_regulation BAX TNF 19334572 2052860 The results suggest that HeLa apoptosis was induced by and interferon -gamma , and the increasing expression of P53 may *induce* the expression of [Bax] and prevent the expression of Bcl-2 , via the mitochondrial induction of cell apoptosis . Positive_regulation BAX TNF 20541824 2301948 The expression of iNOS and the promoting apoptosis gene [Bax] and Fas were significantly *up-regulated* by the induction of IL-1beta and . Positive_regulation BAX TNFSF10 11355877 815460 did not *induce* [Bax] expression and/or translocation from cytosol to mitochondria in the K562 cell line . Positive_regulation BAX TNFSF10 12082620 958659 *induced* translocation of [Bax] from cytosol to mitochondria , release of cytochrome c from mitochondria and activation of caspase-9 were all inhibited by PKC activation . Positive_regulation BAX TNFSF10 12082629 958664 *induced* translocation of [Bax] subsequent to the cleavage of Bid in parental cells . Positive_regulation BAX TNFSF10 12536078 1049664 *induced* the expression of pro-apoptotic proteins , Bad and [Bax] ; Positive_regulation BAX TNFSF10 12761581 1091690 Bcl-2 and Bcl-xL , but not DNC8 , inhibited *induced* [Bax] activation . Positive_regulation BAX TNFSF10 15205314 1261170 Additional characterization revealed that hypoxia significantly inhibits *induced* translocation of [Bax] from the cytosol to the mitochondria in HCT116 and A549 cells , with the concomitant inhibition of cytochrome c release from the mitochondria . Positive_regulation BAX TNFSF10 15623604 1349136 Bcl-2 inhibited *induced* [Bax] translocation , cytosolic release of cytochrome c and Smac/DIABLO , and the downstream cleavage of XIAP and DFF45 . Positive_regulation BAX TNFSF10 16103097 1444532 Generation of ROS by CCCP was responsible for *induced* [Bax] and caspase activation because scavenging ROS completely abrogated apical caspase-8 activation and further downstream events leading to cell death . Positive_regulation BAX TNFSF10 19118042 2019276 Obatoclax potentiated mediated [Bax/Bak] *activation* and the release of mitochondrial cytochrome c , Smac , and AIF . Positive_regulation BAX TNFSF10 24231449 2903133 We also observed that the combination NBIF and *increased* expression of [BAX] . Positive_regulation BBC3 TNF 19444283 2114788 In this study , we found that [p53 upregulated modulator of apoptosis] ( PUMA ) , a p53 downstream target and a BH3-only Bcl-2 family member , is directly regulated by NF-kappaB in *response* to . Positive_regulation BCAP31 TLR7 20083668 2205986 Critical role of the IFN stimulated gene factor 3 complex in *mediated* [IL-27p28] gene expression revealing a two-step activation process . Positive_regulation BCHE IGFBP1 12359954 994819 Serum pre-albumin and [cholinesterase] *increased* with , whereas serum creatinine decreased when compared to controls ( p < 0.05 ) . Positive_regulation BCL10 CAPN8 19220664 2114074 Na+/H+ exchanger mediates TNF-alpha induced hepatocyte apoptosis via the *dependent* degradation of [Bcl-xL] . Positive_regulation BCL10 CAPN8 23823868 2808651 Additionally , we show that degradation of deamidated [Bcl-xL] is *mediated* at least in part by . Positive_regulation BCL10 EPHB2 12592339 1060372 Moreover , [Bcl-X] ( L ) upregulation was *dependent* on signaling . Positive_regulation BCL10 EPHB2 15459189 1335081 Using the selective mitogen activated protein kinase kinase inhibitor PD98059 , we found that Nef induced signaling is *essential* for [Bcl-XL] up-regulation and cell survival . Positive_regulation BCL10 EPHB2 15459189 1335087 These data suggest that Nef produces survival signals in myeloid cells through mediated [Bcl-XL] *induction* , a pathway distinct from Nef survival pathways recently reported in T lymphocytes . Positive_regulation BCL10 FAS 11222094 787483 In conclusion , our results suggest that HTLV-2 is capable of inhibiting *mediated* apoptosis by means of a mechanism involving the tax-2 gene and probably the expression of [bcl-x] ( L ) messenger and protein . Positive_regulation BCL10 FAS 9317114 456236 In A20 cells , signaling may thus *trigger* both ICE activation and [Bcl-x] and Bcl-2 down-regulation . Positive_regulation BCL10 FOXO1 10871843 708224 Further , we present evidence that both PAX3 and can transcriptionally *activate* the [Bcl-x] gene promoter in cotransfection assays . Positive_regulation BCL10 GLP1R 24269940 2893116 Finally , GW exerted anti-apoptotic effects via interfering with *dependent* Akt/Bcl-2 and [Bcl-xl/caspase-3] signaling pathways . Positive_regulation BCL10 ID1 18158619 1971457 expression *resulted* in increased number of viable cells , reduced Bax expression , enhanced Bcl-2 expression , but no change in [Bcl-xL] expression . Positive_regulation BCL10 ID1 20697353 2335478 *enhances* RING1b E3 [ubiquitin ligase] activity through the Mel-18/Bmi-1 polycomb group complex . Positive_regulation BCL10 MAP2K6 11098053 786436 By contrast , activity required EGFR activation and , as shown by use of the MEK inhibitor PD98059 and a dominant negative MEK construct , was *necessary* for [Bcl-x] ( L ) expression and survival . Positive_regulation BCL10 MAP2K6 11098053 786451 In conclusion , our results demonstrate that EGFR dependent activity *contributes* to both [Bcl-x] ( L ) expression and survival of normal keratinocytes . Positive_regulation BCL10 MAP2K6 12592339 1060378 Moreover , [Bcl-X] ( L ) upregulation was *dependent* on signaling . Positive_regulation BCL10 MAP2K6 17942397 1830630 Shp2E76K induced [Bcl-XL] expression was *suppressed* by inhibitors and by a dominant negative Mek1 mutant but not by the phosphoinositide 3-phosphate inhibitor LY294002 and the Akt inhibitor API-2 . Positive_regulation BCL10 PECAM1 20813004 2330696 Of note , cross linking , obtained with a specific monoclonal antibody ( mAb ) , induced phosphatidylinositol-3-kinase dependent Akt phosphorylation and nuclear translocation of the nuclear factor-kBp65 and p52 subunits in both CLL groups , *leading* to upregulation of Bcl-2 and [Bcl-x] ( L ) transcription and increased cell survival . Positive_regulation BCL10 PLAU 19097687 2042010 This study demonstrates that [Bcl-w] additionally *induces* expression and FAK activation . Positive_regulation BCL10 SMN2 22732506 2639178 Conversely , expression *increases* [Bcl-xL] protein levels by ~6-fold in SH-SY5Y cells , and ~2.5-fold in the brains of transgenic mice over expressing SMN ( PrP-SMN ) . Positive_regulation BCL10 TNF 10085086 599326 *induces* Bcl-2 and [Bcl-x] expression through NFkappaB activation in primary hippocampal neurons . Positive_regulation BCL10 TNF 10085086 599367 Expression of the mutant NFkappaB completely inhibited NFkappaB DNA binding activity and inhibited both *induced* up-regulation of Bcl-2 and [Bcl-x] expression and neuroprotective effect . Positive_regulation BCL10 TNF 11266466 796908 We conclude that NGF and *induce* different signaling pathways in neurons to activate NFkappaB and [bcl-x] gene expression . Positive_regulation BCL10 TNF 11292287 800843 The cells acquired resistance to *mediated* apoptosis ( 50-100 % reduction at 6 hr ) and up-regulated expression of Bcl-2 and [Bcl-xl] ; Positive_regulation BCL10 TNF 11720092 883922 Moreover , crocin suppressed the *induced* expression of [Bcl-Xs] and LICE mRNAs and simultaneously restored the cytokine induced reduction of Bcl-X ( L ) mRNA expression . Positive_regulation BCL10 TNF 16142752 1454896 Bcl-xL or Ets-2 overexpression protected osteoclasts from ALN induced apoptosis , and *stimulated* [Bcl-xL] and Ets-2 expression in osteoclasts . Positive_regulation BCL10 TNF 16192349 1468336 In the absence of RelA phosphorylation on serine-276 , stimulation *leads* to a strong increase in the expression of endogenous NF-kappaB-responsive genes , such as [Bcl-xL] , whose transcriptional up-regulation is mainly controlled by RelB . Positive_regulation BCL10 TNF 16280327 1509408 A pathway for *induced* [Bcl10] nuclear translocation . Positive_regulation BCL10 TNF 17906102 1830129 The antioxidant Trolox modulated *induced* changes in [Bax/Bcl-xl] , cell injury , and MAPKs . Positive_regulation BCL10 TNF 20363734 2266645 We found that either PP2A inhibitor okadaic acid or depletion of catalytic subunit alpha of PP2A ( PP2A/Calpha ) by small interfering RNA enhanced [Bcl-x] ( L ) phosphorylation when activated with hydrogen peroxide and alpha *induced* oxidative stress . Positive_regulation BCL10 TNF 20937806 2353622 induced the ubiquitination of TRAF2 ( TNF receptor associated factor 2 ) , which interacts with NIK , and CGN *induced* phosphorylation of [BCL10] , leading to increased NIK phosphorylation . Positive_regulation BCL2 ANGPT1 16701012 1560548 could decrease the expression of Bax , caspase3 and 8 , and *increase* that of [Bcl-2] . Positive_regulation BCL2 CAPN8 17987264 1859917 The events of apoptosis included increase in expression of Bax , down regulation of [Bcl-2] and baculoviral inhibitor-of-apoptosis protein (IAP) repeat containing ( BIRC ) proteins , mitochondrial release of cytochrome c and Smac into the cytosol , increase in intracellular free [ Ca ( 2+ ) ] , and *activation* of , caspase-9 , and caspase-3 . Positive_regulation BCL2 CAPN8 18602901 1947229 Besides , apoptosis was associated with alterations in expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins resulting in an increase in Bax : [Bcl-2] ratio , mitochondrial release of cytochrome c and Smac , downregulation of selective baculoviral inhibitor-of-apoptosis repeat containing ( BIRC ) molecules , an increase in intracellular free [ Ca2+ ] , and *activation* of and caspase-3 . Positive_regulation BCL2 CAPN8 19220664 2114088 Na+/H+ exchanger mediates TNF-alpha induced hepatocyte apoptosis via the *dependent* degradation of [Bcl-xL] . Positive_regulation BCL2 CAPN8 23823868 2808665 Additionally , we show that degradation of deamidated [Bcl-xL] is *mediated* at least in part by . Positive_regulation BCL2 CCND1 11313702 805535 [Bcl-2] *induces* promoter activity in human breast epithelial cells independent of cell anchorage . Positive_regulation BCL2 EPHB2 10097113 601584 Paclitaxel induced apoptosis was associated with phosphorylation of [Bcl-2] and *activation* of and JNK MAPKs . Positive_regulation BCL2 EPHB2 10376521 623373 Taxol induced apoptosis was associated with phosphorylation of both c-Raf-1 and [Bcl-2] and *activation* of and JNK MAP kinases . Positive_regulation BCL2 EPHB2 11207305 786920 Importantly , when TCR activated thymocytes are simultaneously coengaged by both CD28 and CD2 receptors , CD28 signals can inhibit *dependent* [Bcl-2] protein up-regulation . Positive_regulation BCL2 EPHB2 15225643 1268302 The phosphorylation status and anti-apoptotic activity of [Bcl-2] are *regulated* by and protein phosphatase 2A on the mitochondria . Positive_regulation BCL2 EPHB2 15459189 1335082 Using the selective mitogen activated protein kinase kinase inhibitor PD98059 , we found that Nef induced signaling is *essential* for [Bcl-XL] up-regulation and cell survival . Positive_regulation BCL2 EPHB2 15459189 1335088 These data suggest that Nef produces survival signals in myeloid cells through mediated [Bcl-XL] *induction* , a pathway distinct from Nef survival pathways recently reported in T lymphocytes . Positive_regulation BCL2 EPHB2 15935058 1414835 FGF-2 treatment caused an *dependent* increase in [Bcl-2] and an ERK independent increase in Bcl-x ( L ) . Positive_regulation BCL2 EPHB2 16152590 1517356 [Bcl-2] phosphorylation and *activation* of and JNK and caspase 3-dependent cleavage of PARP were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation BCL2 EPHB2 16273078 1566894 Cyclin dependent kinase-5 prevents neuronal apoptosis through *mediated* upregulation of [Bcl-2] . Positive_regulation BCL2 EPHB2 16806162 1585956 The increased expression of Egr-1 and [Bcl-2] by isoflurane was *inhibited* by inhibition . Positive_regulation BCL2 EPHB2 18438930 1932638 Thus , *dependent* p35 up-regulation and MAPK/ERK dependent and PI3K/Akt dependent [Bcl2] up-regulation contribute to BDNF stimulated neural differentiation and to the survival of differentiated cells . Positive_regulation BCL2 EPHB2 18674530 1960744 We also found that propofol treatment enhanced expression of anti-apoptotic protein [Bcl-2] and *activation* of concerned with survival . Positive_regulation BCL2 EPHB2 20191008 2216251 In addition , both enhancement of anti-apoptotic protein [Bcl-2] and *activation* of concerned with survival were shown . Positive_regulation BCL2 EPHB2 21292437 2414595 Silencing *increased* CyclinD1 , cyclindependent kinase 6 (CDK6) and [Bcl-2] expression in both mRNA and protein levels compared with Control RNAi . Positive_regulation BCL2 EPHB2 22466960 2583241 Moreover , activation upregulated Beclin-1 expression through induction of Bcl-2 phosphorylation , but p53 did not *induce* [Bcl-2] phosphorylation . Positive_regulation BCL2 EPHB2 23732112 2811891 The disruption of mitochondrial outer membrane permeabilisation , the activation of caspase-3/7 and 9 , the downregulation of [Bcl-2] , the upregulation of Bax , and the *activation* of p38 MAPK , and NF-?B were all observed in HIV-1 Tat treated RPE cells . Positive_regulation BCL2 EPHB2 24523904 2914718 We also demonstrate that the mechanism involves break down of mitochondrial membrane potential , down regulation of [Bcl-2] and reduced *activation* of Akt and 42/44 . Positive_regulation BCL2 EPHB2 24573418 2919820 Low expression of Mig-6 is associated with poor survival outcome in NSCLC and inhibits cell apoptosis via *mediated* upregulation of [Bcl-2] . Positive_regulation BCL2 F3 18325115 1886202 *activates* [Bcl-2] and prevents doxorubicin induced apoptosis in neuroblastoma cells . Positive_regulation BCL2 FAS 12714376 1140839 IL-11 inhibited *induced* apoptosis and increased [Bcl-2] expression in both normal-Fb and IPF-Fb . Positive_regulation BCL2 FAS 12878322 1115568 These data suggest that in our experimental model , acylphosphatase could be involved in the recovery of SERCA2a activity , while cardiomyocyte apoptosis might be triggered by a decline in [Bcl-2] expression and a concomitant *activation* of . Positive_regulation BCL2 FAS 16313119 1486891 Compared with Group B , the apoptotic cardiomyocyte in Group C was significantly reduced ( P < 0.01 ) , with the expression of and Caspase3 significantly lowered but expression of [Bcl-2] *increased* slightly . Positive_regulation BCL2 FAS 21425578 2406147 As compared with the control group , after toosendanin treatment , expression of [Bcl-2] decreased , and that of Bax and *increased* in SMMC-7721 cells ; Positive_regulation BCL2 FAS 9764613 537374 Anti-Fas MoAb induced apoptosis of RA synovial cells in vitro , and proinflammatory cytokines tumour necrosis factor-alpha (TNF-alpha) and IL-1beta , but not IL-6 or IL-8 , inhibited the *induced* apoptosis accompanying up-regulation of [Bcl-2] protein expression and reduced expression of CPP32 and ICH-1L . Positive_regulation BCL2 FUT4 21337384 2411172 Western blot analysis showed that overexpression decreased expression of Bax , Caspase 3 , and PARP proteins , and *increased* anti-apoptotic [Bcl-2] protein in A431 cells . Positive_regulation BCL2 GLP1R 24269940 2893117 Finally , GW exerted anti-apoptotic effects via interfering with *dependent* [Akt/Bcl-2] and Bcl-xl/caspase-3 signaling pathways . Positive_regulation BCL2 HBEGF 20593979 2334416 Recombinant *induced* the [Bcl-2] , Bcl-xL mRNA/protein expression in HET-1A and TTn cells . Positive_regulation BCL2 ID1 18158619 1971443 *regulates* [Bcl-2] and Bax expression through p53 and NF-kappaB in MCF-7 breast cancer cells . Positive_regulation BCL2 ID1 18158619 1971458 expression *resulted* in increased number of viable cells , reduced Bax expression , enhanced Bcl-2 expression , but no change in [Bcl-xL] expression . Positive_regulation BCL2 ID1 20945346 2389307 *regulated* the expression levels of anti-apoptotic [Bcl-2] and pro-apoptotic Bax , and resulted in delay of apoptotic peak during postlactational involution . Positive_regulation BCL2 IL1B 10657679 664248 In addition , significantly *increased* the expression of [Bcl-2] . Positive_regulation BCL2 IL1B 21180129 1847788 L-NA could inhibit the increase in the expression of TNF-alpha and the content of , and protect neurons from apoptosis induced by focal cerebral ischemia through *increasing* the [Bcl-2] protein expression and inhibiting the Bax protein expression . Positive_regulation BCL2 LBP 19735167 2134515 The ratio of Bcl-2/Bax protein expression following LBP treatments decreased significantly with a dose-effect relationship , which suggested that can *regulate* the expression of [Bcl-2] and Bax to induce apoptosis of PC-3 and DU-145 cells . Positive_regulation BCL2 LBP 24595452 2920505 at the dose of 40 mg/kg significantly suppressed overexpression of Bax , CytC , Caspase-3 , -9 and cleaved PARP-1 , and *inhibited* the reduction of [Bcl-2] expression . Positive_regulation BCL2 MAOA 22065207 2567962 The novel *role* of in [Bcl-2] induction by rasagiline is discussed with regard to the molecular mechanism underlying neuroprotection by the MAO inhibitors . Positive_regulation BCL2 MAP2K6 10677502 668167 A role for a MEK/MAPK as a responsible SRK was implicated because the highly specific inhibitor , PD98059 , also can only partially *inhibit* IL-3 induced [Bcl2] phosphorylation , whereas the combination of PD98059 and stauro completely blocks phosphorylation and synergistically enhances apoptosis . Positive_regulation BCL2 MAP2K6 11160861 781879 Overexpression of a dominant negative mutant , 1 ( MEKK1-DN ) or treatment with JNK-specific antisense oligonucleotide *prevented* paclitaxel induced JNK activation , [Bcl-2] phosphorylation and apoptosis . Positive_regulation BCL2 MAP2K6 17942397 1830638 Shp2E76K induced [Bcl-XL] expression was *suppressed* by inhibitors and by a dominant negative Mek1 mutant but not by the phosphoinositide 3-phosphate inhibitor LY294002 and the Akt inhibitor API-2 . Positive_regulation BCL2 MAP2K6 22022968 2499127 Mycobacterium tuberculosis H37Rv- and H37Ra induced [Bcl-2] production was *reduced* by specific inhibitors of ( PD98059 ) and p38 ( SB203580 ) , but increased by nuclear factor ?B ( NF-?B ) inhibitor ( BAY 11-7082 ) . Positive_regulation BCL2 MMP28 11960369 931632 When added to isolated mitochondria , BaxBH3 and [Bcl2BH3] *induced* , which was inhibited by CsA . Positive_regulation BCL2 MMP28 11960369 931720 In conclusion , BaxBH3 and [Bcl2BH3] *induce* and apoptosis through a mechanism which overcomes cytoprotection by Bcl-2 and Bcl-X ( L ) . Positive_regulation BCL2 MMP28 17541305 1762474 Moreover , [Bcl-2] *induced* the expression of in tumors grown in the orthotopic sites even though no appreciable effects were observed in the in vitro condition . Positive_regulation BCL2 MMP7 11960369 931647 When added to isolated mitochondria , BaxBH3 and [Bcl2BH3] *induced* , which was inhibited by CsA . Positive_regulation BCL2 MMP7 11960369 931735 In conclusion , BaxBH3 and [Bcl2BH3] *induce* and apoptosis through a mechanism which overcomes cytoprotection by Bcl-2 and Bcl-X ( L ) . Positive_regulation BCL2 MMP7 17541305 1762489 Moreover , [Bcl-2] *induced* the expression of in tumors grown in the orthotopic sites even though no appreciable effects were observed in the in vitro condition . Positive_regulation BCL2 PECAM1 20813004 2330697 Of note , cross linking , obtained with a specific monoclonal antibody ( mAb ) , induced phosphatidylinositol-3-kinase dependent Akt phosphorylation and nuclear translocation of the nuclear factor-kBp65 and p52 subunits in both CLL groups , *leading* to upregulation of [Bcl-2] and Bcl-x ( L ) transcription and increased cell survival . Positive_regulation BCL2 PLAU 19097687 2042011 This study demonstrates that [Bcl-w] additionally *induces* expression and FAK activation . Positive_regulation BCL2 RCAN1 23150431 2751923 Furthermore , *induced* the expression of the CREB target gene , [Bcl-2] . Positive_regulation BCL2 SMN2 22732506 2639185 Conversely , expression *increases* [Bcl-xL] protein levels by ~6-fold in SH-SY5Y cells , and ~2.5-fold in the brains of transgenic mice over expressing SMN ( PrP-SMN ) . Positive_regulation BCL2 TF 22661889 2610888 Compared to mPEG2000-DSPE liposomes , TPGS liposomes improved the cytotoxicity of emodin on leukemia cells by regulating the protein levels of myeloid cell leukemia 1 (Mcl-1) , [B-cell lymphoma-2 (Bcl-2)] and Bcl-2 associated X protein , which was further *enhanced* by . Positive_regulation BCL2 TNF 10085086 599327 *induces* [Bcl-2] and Bcl-x expression through NFkappaB activation in primary hippocampal neurons . Positive_regulation BCL2 TNF 10085086 599368 Expression of the mutant NFkappaB completely inhibited NFkappaB DNA binding activity and inhibited both induced *up-regulation* of [Bcl-2] and Bcl-x expression and neuroprotective effect . Positive_regulation BCL2 TNF 11292287 800844 The cells acquired resistance to *mediated* apoptosis ( 50-100 % reduction at 6 hr ) and up-regulated expression of Bcl-2 and [Bcl-xl] ; Positive_regulation BCL2 TNF 11600573 870743 IL-1beta , interferon gamma , and *caused* no major change in either islet cell survival or [Bcl-2] and Bax mRNA expression after a 12-h incubation ; Positive_regulation BCL2 TNF 11720092 883923 Moreover , crocin suppressed the *induced* expression of [Bcl-Xs] and LICE mRNAs and simultaneously restored the cytokine induced reduction of Bcl-X ( L ) mRNA expression . Positive_regulation BCL2 TNF 12297009 991031 Accordingly , [Bcl-2] , an anti-apoptotic Bcl-2 family member , was highly expressed in *response* to . Positive_regulation BCL2 TNF 15094967 1238352 Pretreatment of cells with the PPAR-gamma ligand pioglitazone blocked *mediated* apoptosis , caspase-3 activation , expression of [Bcl-2] , and lipid peroxidation ( P < .01 vs TNF-alpha alone ) . Positive_regulation BCL2 TNF 15518816 1328738 Furthermore , using an inhibitor of NF-kappaB activation , we demonstrated that *induced* upregulation of Bcl-x ( L ) and [Bcl-2] occurs , respectively , through a NF-kappaB dependent and an NF-kappaB independent pathway . Positive_regulation BCL2 TNF 15538942 1336714 The prosurvival effect of might be at least partly *mediated* by modulating the expression and subcellular localization of [Bcl-2] family proteins . Positive_regulation BCL2 TNF 16142752 1454898 Bcl-xL or Ets-2 overexpression protected osteoclasts from ALN induced apoptosis , and *stimulated* [Bcl-xL] and Ets-2 expression in osteoclasts . Positive_regulation BCL2 TNF 16192349 1468337 In the absence of RelA phosphorylation on serine-276 , stimulation *leads* to a strong increase in the expression of endogenous NF-kappaB-responsive genes , such as [Bcl-xL] , whose transcriptional up-regulation is mainly controlled by RelB . Positive_regulation BCL2 TNF 16860828 1632256 The *induced* ROS generation , lipid peroxidation , antioxidant enzyme consumption , a proapoptotic predominant expression of [Bcl-2] family proteins , and a disruption of mitochondrial membrane potential were all inhibited by E2 , and then they were further stimulated by progesterone in HuH-7 cells . Positive_regulation BCL2 TNF 17322420 1765785 CYP epoxygenase overexpression also significantly inhibited caspase-3 activity and downregulation of [Bcl-2] expression *induced* by . Positive_regulation BCL2 TNF 17906102 1830130 The antioxidant Trolox modulated *induced* changes in [Bax/Bcl-xl] , cell injury , and MAPKs . Positive_regulation BCL2 TNF 19034929 2017255 It suppresses *induced* [Bcl-2] expression and potentiates chemotherapeutic agents mediated cell death . Positive_regulation BCL2 TNF 20691248 2311986 and HSP-70 together *increased* [Bcl-2] levels by 70 % . Positive_regulation BCL2 TNF 20934513 2381941 [Bcl-2] and Hsp72 expression was significantly increased in PS compared to control ( 0.90±0.60 vs 0.63±0.033 ; 0.72±0.10 vs 0.28±0.098 ) , in the *presence* of a level increased by 50.7 % . Positive_regulation BCL2 TNF 21820422 2490445 Triptolide also abrogated *induced* expression of cell survival proteins ( XIAP , Bcl-x ( L ) , [Bcl-2] , survivin , cIAP-1 and cIAP-2 ) , cell proliferative proteins ( cyclin D1 , c-myc and cyclooxygenase-2 ) , and metastasis proteins ( ICAM-1 and MMP-9 ) . Positive_regulation BCL2 TNF 22038739 2562576 however , neither pre-miR-23a nor LNA-anti-miR-23a had an effect on *induced* [Bcl-2] activation . Positive_regulation BCL2 TNF 23174100 2700540 Our results showed that TNF-alpha treatment increased Bcl-2 mRNA and protein levels in breast cancer cells , suggesting that [Bcl-2] is directly regulated by nuclear factor-kappaB (NF-kappaB) in *response* to . Positive_regulation BCL2 TNF 9581775 503480 plus NAC treatment *resulted* in a marked decrease in [Bcl-2] protein levels in HIV-1 infected cells , coupled with an increase in Bax protein compared to uninfected cells , suggesting that the difference in susceptibility to TNFalpha induced apoptosis may relate to the differences in relative levels of Bcl-2 and Bax . Positive_regulation BCL2 TNFSF10 11569166 864219 So far most attention was paid to two ways of apoptosis induction of tumor cells : suppressed translation of the antiapoptic factor [Bcl 2] by means of an antisense nucleotide and *induction* of apoptosis by ( TNF related apoptosis inducing ligand ) . Positive_regulation BCL2 TNFSF10 16848771 1588411 We conclude that *induced* apoptosis in a subpopulation of chemotherapy-refractory nodal DLBCL and that disruption of the intrinsic apoptosis mediated pathway and expression of [Bcl-2] and XIAP did not confer resistance to hsTRAIL/Apo2L induced apoptosis in DLBCL . Positive_regulation BCL2A1 CAPN8 16094403 1443652 In vitro studies suggest that *mediated* cleavage of [Bfl-1] occurs between its Bcl-2 homology (BH)4 and BH3 domains . Positive_regulation BCL2A1 CAPN8 22745672 2621840 Here we demonstrate that *mediated* cleavage of full-length [Bfl-1] induces the release of C-terminal membrane active a-helices that are responsible for its conversion into a pro-apoptotic factor . Positive_regulation BCL2A1 TNF 14599550 1161284 Furthermore , treatment of cells with these compounds prevented the *induced* expression of anti-apoptotic NF-kappaB target genes [Bfl-1/A1] , a prosurvival Bcl-2 homologue , and resulted in sensitizing HT-1080 cells to TNF-alpha induced cell death . Positive_regulation BCL2A1 TNF 16924232 1692195 *induced* the expression of NF-kappaB regulated gene products cyclin D1 , c-Myc , matrix metalloproteinase-9 , survivin , X-linked inhibitor-of-apoptosis protein ( IAP ) , IAP1 , Bcl-x ( L ) , [A1/Bfl-1] and Fas associated death domain protein-like IL-1beta converting enzyme-inhibitory protein in wild-type MEF but not in PKR-/- cells . Positive_regulation BCL2A1 TNF 16984800 1633669 Celastrol prevented not only LPS induced mRNA expression of iNOS and TNF-alpha , but also *induced* [Bfl-1/A1] expression , a prosurvival Bcl-2 homologue . Positive_regulation BCL2A1 TNF 19489038 2128382 We first determined that the C/EBPbeta-C overexpression or siRNA mediated C/EBPbeta depletion decreased *induced* promoter activities of [Bfl-1] , IL-6 , and IL-8 genes . Positive_regulation BCL2A1 TNF 19489038 2128387 Conversely , overexpression of C/EBPbeta-A in LNCaP cells increased resistance to TNF induced cell death and *induced* promoter activities of IL-6 and [Bfl-1] . Positive_regulation BCL2A1 TNF 20705940 2437278 We report that granulocyte/macrophage colony stimulating factor ( GM-CSF ) and *prevent* the normal time dependent loss of Mcl-1 and [Bcl2A1] in neutrophils , and we demonstrate that they cause an NF-?B dependent increase in Bcl-X ( L ) transcription/translation . Positive_regulation BCL2L11 FOXO1 19553561 2128956 activation *resulted* in a significant increase in muscle atrophy F-box (MAFbx)/atrogin-1 , muscle-specific RING finger protein 1 ( MuRF-1 ) , and [Bcl-2 interacting mediator of cell death] ( Bim ) gene expression , with no significant increase in Bcl-2/adenovirus E1B 19-kDa interacting protein 3 ( BNip3 ) gene expression . Positive_regulation BCL3 CAPN8 19220664 2114102 Na+/H+ exchanger mediates TNF-alpha induced hepatocyte apoptosis via the *dependent* degradation of [Bcl-xL] . Positive_regulation BCL3 CAPN8 23823868 2808679 Additionally , we show that degradation of deamidated [Bcl-xL] is *mediated* at least in part by . Positive_regulation BCL3 CCND1 11713278 880874 The putative oncoprotein [Bcl-3] *induces* to stimulate G ( 1 ) transition . Positive_regulation BCL3 CCND1 16940298 1627462 Here we show that HBx up-regulates and that this process is *mediated* by the NF-kappaB2 ( p52 ) [/BCL-3] complex . Positive_regulation BCL3 EPHB2 15459189 1335083 Using the selective mitogen activated protein kinase kinase inhibitor PD98059 , we found that Nef induced signaling is *essential* for [Bcl-XL] up-regulation and cell survival . Positive_regulation BCL3 EPHB2 15459189 1335089 These data suggest that Nef produces survival signals in myeloid cells through mediated [Bcl-XL] *induction* , a pathway distinct from Nef survival pathways recently reported in T lymphocytes . Positive_regulation BCL3 GLP1R 24269940 2893118 Finally , GW exerted anti-apoptotic effects via interfering with *dependent* Akt/Bcl-2 and [Bcl-xl/caspase-3] signaling pathways . Positive_regulation BCL3 ID1 18158619 1971459 expression *resulted* in increased number of viable cells , reduced Bax expression , enhanced Bcl-2 expression , but no change in [Bcl-xL] expression . Positive_regulation BCL3 IL1B 10469655 641348 We show that TNFalpha , or phorbolester ( PMA ) *trigger* rapid formation of [Bcl-3-p50] complexes with the same kinetics as activation of p50-p65 complexes . Positive_regulation BCL3 MAP2K6 17942397 1830646 Shp2E76K induced [Bcl-XL] expression was *suppressed* by inhibitors and by a dominant negative Mek1 mutant but not by the phosphoinositide 3-phosphate inhibitor LY294002 and the Akt inhibitor API-2 . Positive_regulation BCL3 PLAU 19097687 2042012 This study demonstrates that [Bcl-w] additionally *induces* expression and FAK activation . Positive_regulation BCL3 SMN2 22732506 2639192 Conversely , expression *increases* [Bcl-xL] protein levels by ~6-fold in SH-SY5Y cells , and ~2.5-fold in the brains of transgenic mice over expressing SMN ( PrP-SMN ) . Positive_regulation BCL3 TNF 10469655 641349 *induced* [Bcl-3-p50] formation requires proteasome activity , but is independent of p50-p65 released from IkappaBalpha , indicating a pathway that involves p105 proteolysis . Positive_regulation BCL3 TNF 11292287 800845 The cells acquired resistance to *mediated* apoptosis ( 50-100 % reduction at 6 hr ) and up-regulated expression of Bcl-2 and [Bcl-xl] ; Positive_regulation BCL3 TNF 11387332 842432 Two observations are interpreted to indicate that bcl-3 is transactivated by NF-kappa B/Rel A : 1 ) expression of a dominant negative NF-kappa B inhibitor blocks *induced* [BCL-3] expression and 2 ) expression of constitutively active Rel A is sufficient to induce BCL-3 expression . Positive_regulation BCL3 TNF 11720092 883924 Moreover , crocin suppressed the *induced* expression of [Bcl-Xs] and LICE mRNAs and simultaneously restored the cytokine induced reduction of Bcl-X ( L ) mRNA expression . Positive_regulation BCL3 TNF 16142752 1454900 Bcl-xL or Ets-2 overexpression protected osteoclasts from ALN induced apoptosis , and *stimulated* [Bcl-xL] and Ets-2 expression in osteoclasts . Positive_regulation BCL3 TNF 16192349 1468339 In the absence of RelA phosphorylation on serine-276 , stimulation *leads* to a strong increase in the expression of endogenous NF-kappaB-responsive genes , such as [Bcl-xL] , whose transcriptional up-regulation is mainly controlled by RelB . Positive_regulation BCL3 TNF 17008396 1674109 These data suggest that in wild-type MEC , *stimulates* the interaction of [bcl3] with p50 and p52 , and the binding of p52 , as well as RelB , to cyclin D1 promoter kappaB sites , and as a consequence , stimulates the growth of MEC . Positive_regulation BCL3 TNF 17906102 1830131 The antioxidant Trolox modulated *induced* changes in [Bax/Bcl-xl] , cell injury , and MAPKs . Positive_regulation BCL3 TNF 19191868 2061286 [Bcl-3] was *induced* in myeloma cell lines by interleukin (IL)-6 , IL-21 , IL-15 , and IGF-1 , and its upregulation was associated with increased proliferation of the cells . Positive_regulation BCL5 CAPN8 19220664 2114032 Na+/H+ exchanger mediates TNF-alpha induced hepatocyte apoptosis via the *dependent* degradation of [Bcl-xL] . Positive_regulation BCL5 CAPN8 23823868 2808609 Additionally , we show that degradation of deamidated [Bcl-xL] is *mediated* at least in part by . Positive_regulation BCL5 EPHB2 15459189 1335078 Using the selective mitogen activated protein kinase kinase inhibitor PD98059 , we found that Nef induced signaling is *essential* for [Bcl-XL] up-regulation and cell survival . Positive_regulation BCL5 EPHB2 15459189 1335084 These data suggest that Nef produces survival signals in myeloid cells through mediated [Bcl-XL] *induction* , a pathway distinct from Nef survival pathways recently reported in T lymphocytes . Positive_regulation BCL5 GLP1R 24269940 2893109 Finally , GW exerted anti-apoptotic effects via interfering with *dependent* Akt/Bcl-2 and [Bcl-xl/caspase-3] signaling pathways . Positive_regulation BCL5 ID1 18158619 1971453 expression *resulted* in increased number of viable cells , reduced Bax expression , enhanced Bcl-2 expression , but no change in [Bcl-xL] expression . Positive_regulation BCL5 MAP2K6 17942397 1830606 Shp2E76K induced [Bcl-XL] expression was *suppressed* by inhibitors and by a dominant negative Mek1 mutant but not by the phosphoinositide 3-phosphate inhibitor LY294002 and the Akt inhibitor API-2 . Positive_regulation BCL5 PLAU 19097687 2042001 This study demonstrates that [Bcl-w] additionally *induces* expression and FAK activation . Positive_regulation BCL5 SMN2 22732506 2639157 Conversely , expression *increases* [Bcl-xL] protein levels by ~6-fold in SH-SY5Y cells , and ~2.5-fold in the brains of transgenic mice over expressing SMN ( PrP-SMN ) . Positive_regulation BCL5 TNF 11292287 800840 The cells acquired resistance to *mediated* apoptosis ( 50-100 % reduction at 6 hr ) and up-regulated expression of Bcl-2 and [Bcl-xl] ; Positive_regulation BCL5 TNF 11720092 883919 Moreover , crocin suppressed the *induced* expression of [Bcl-Xs] and LICE mRNAs and simultaneously restored the cytokine induced reduction of Bcl-X ( L ) mRNA expression . Positive_regulation BCL5 TNF 16142752 1454883 Bcl-xL or Ets-2 overexpression protected osteoclasts from ALN induced apoptosis , and *stimulated* [Bcl-xL] and Ets-2 expression in osteoclasts . Positive_regulation BCL5 TNF 16192349 1468332 In the absence of RelA phosphorylation on serine-276 , stimulation *leads* to a strong increase in the expression of endogenous NF-kappaB-responsive genes , such as [Bcl-xL] , whose transcriptional up-regulation is mainly controlled by RelB . Positive_regulation BCL5 TNF 17906102 1830125 The antioxidant Trolox modulated *induced* changes in [Bax/Bcl-xl] , cell injury , and MAPKs . Positive_regulation BCL6 CAPN8 19220664 2114046 Na+/H+ exchanger mediates TNF-alpha induced hepatocyte apoptosis via the *dependent* degradation of [Bcl-xL] . Positive_regulation BCL6 CAPN8 23823868 2808623 Additionally , we show that degradation of deamidated [Bcl-xL] is *mediated* at least in part by . Positive_regulation BCL6 EPHB2 15459189 1335079 Using the selective mitogen activated protein kinase kinase inhibitor PD98059 , we found that Nef induced signaling is *essential* for [Bcl-XL] up-regulation and cell survival . Positive_regulation BCL6 EPHB2 15459189 1335085 These data suggest that Nef produces survival signals in myeloid cells through mediated [Bcl-XL] *induction* , a pathway distinct from Nef survival pathways recently reported in T lymphocytes . Positive_regulation BCL6 FOXO1 19929250 2167289 Gain of function approaches indicated that activation was *sufficient* to activate [bcl-6] transcription , while Bcl-6 repressed cyclin D2 transcription and proliferation . Positive_regulation BCL6 GLP1R 24269940 2893110 Finally , GW exerted anti-apoptotic effects via interfering with *dependent* Akt/Bcl-2 and [Bcl-xl/caspase-3] signaling pathways . Positive_regulation BCL6 HBEGF 19337254 2056517 The nuclear translocation *leads* to the interaction of [BCL6] with HB-EGF-CTF and the nuclear export of BCL6 , and after that BCL6 degradation was mediated by ubiquitin/proteasome pathway . Positive_regulation BCL6 ID1 18158619 1971454 expression *resulted* in increased number of viable cells , reduced Bax expression , enhanced Bcl-2 expression , but no change in [Bcl-xL] expression . Positive_regulation BCL6 MAP2K6 17942397 1830614 Shp2E76K induced [Bcl-XL] expression was *suppressed* by inhibitors and by a dominant negative Mek1 mutant but not by the phosphoinositide 3-phosphate inhibitor LY294002 and the Akt inhibitor API-2 . Positive_regulation BCL6 PLAU 19097687 2042002 This study demonstrates that [Bcl-w] additionally *induces* expression and FAK activation . Positive_regulation BCL6 SMN2 22732506 2639164 Conversely , expression *increases* [Bcl-xL] protein levels by ~6-fold in SH-SY5Y cells , and ~2.5-fold in the brains of transgenic mice over expressing SMN ( PrP-SMN ) . Positive_regulation BCL6 TNF 11292287 800841 The cells acquired resistance to *mediated* apoptosis ( 50-100 % reduction at 6 hr ) and up-regulated expression of Bcl-2 and [Bcl-xl] ; Positive_regulation BCL6 TNF 11720092 883920 Moreover , crocin suppressed the *induced* expression of [Bcl-Xs] and LICE mRNAs and simultaneously restored the cytokine induced reduction of Bcl-X ( L ) mRNA expression . Positive_regulation BCL6 TNF 16142752 1454885 Bcl-xL or Ets-2 overexpression protected osteoclasts from ALN induced apoptosis , and *stimulated* [Bcl-xL] and Ets-2 expression in osteoclasts . Positive_regulation BCL6 TNF 16192349 1468333 In the absence of RelA phosphorylation on serine-276 , stimulation *leads* to a strong increase in the expression of endogenous NF-kappaB-responsive genes , such as [Bcl-xL] , whose transcriptional up-regulation is mainly controlled by RelB . Positive_regulation BCL6 TNF 17906102 1830126 The antioxidant Trolox modulated *induced* changes in [Bax/Bcl-xl] , cell injury , and MAPKs . Positive_regulation BCL6 TNF 20228272 2254444 also *triggered* [Bcl-6] , but independently of STAT3 , whereas IkappaB kinasebeta inhibitor down-regulated TNF-alpha induced Bcl-6 , indicating that the canonical nuclear factor-kappaB pathway mediates TNF-alpha induced Bcl-6 expression . Positive_regulation BCL9 CAPN8 19220664 2114060 Na+/H+ exchanger mediates TNF-alpha induced hepatocyte apoptosis via the *dependent* degradation of [Bcl-xL] . Positive_regulation BCL9 CAPN8 23823868 2808637 Additionally , we show that degradation of deamidated [Bcl-xL] is *mediated* at least in part by . Positive_regulation BCL9 EPHB2 15459189 1335080 Using the selective mitogen activated protein kinase kinase inhibitor PD98059 , we found that Nef induced signaling is *essential* for [Bcl-XL] up-regulation and cell survival . Positive_regulation BCL9 EPHB2 15459189 1335086 These data suggest that Nef produces survival signals in myeloid cells through mediated [Bcl-XL] *induction* , a pathway distinct from Nef survival pathways recently reported in T lymphocytes . Positive_regulation BCL9 GLP1R 24269940 2893111 Finally , GW exerted anti-apoptotic effects via interfering with *dependent* Akt/Bcl-2 and [Bcl-xl/caspase-3] signaling pathways . Positive_regulation BCL9 ID1 18158619 1971455 expression *resulted* in increased number of viable cells , reduced Bax expression , enhanced Bcl-2 expression , but no change in [Bcl-xL] expression . Positive_regulation BCL9 MAP2K6 17942397 1830622 Shp2E76K induced [Bcl-XL] expression was *suppressed* by inhibitors and by a dominant negative Mek1 mutant but not by the phosphoinositide 3-phosphate inhibitor LY294002 and the Akt inhibitor API-2 . Positive_regulation BCL9 PLAU 19097687 2042003 This study demonstrates that [Bcl-w] additionally *induces* expression and FAK activation . Positive_regulation BCL9 SMN2 22732506 2639171 Conversely , expression *increases* [Bcl-xL] protein levels by ~6-fold in SH-SY5Y cells , and ~2.5-fold in the brains of transgenic mice over expressing SMN ( PrP-SMN ) . Positive_regulation BCL9 TNF 11292287 800842 The cells acquired resistance to *mediated* apoptosis ( 50-100 % reduction at 6 hr ) and up-regulated expression of Bcl-2 and [Bcl-xl] ; Positive_regulation BCL9 TNF 11720092 883921 Moreover , crocin suppressed the *induced* expression of [Bcl-Xs] and LICE mRNAs and simultaneously restored the cytokine induced reduction of Bcl-X ( L ) mRNA expression . Positive_regulation BCL9 TNF 16142752 1454887 Bcl-xL or Ets-2 overexpression protected osteoclasts from ALN induced apoptosis , and *stimulated* [Bcl-xL] and Ets-2 expression in osteoclasts . Positive_regulation BCL9 TNF 16192349 1468334 In the absence of RelA phosphorylation on serine-276 , stimulation *leads* to a strong increase in the expression of endogenous NF-kappaB-responsive genes , such as [Bcl-xL] , whose transcriptional up-regulation is mainly controlled by RelB . Positive_regulation BCL9 TNF 17906102 1830127 The antioxidant Trolox modulated *induced* changes in [Bax/Bcl-xl] , cell injury , and MAPKs . Positive_regulation BCR CD22 10671211 666696 On the other hand , up-regulation of after TD stimulation may *allow* increased inhibiting influence of CD22 on neonatal [BCR] signaling , impairing B cell activation and differentiation . Positive_regulation BCR CD22 12055217 951720 Moreover , in CD22-deficient mice , anti-IgM treatment did not trigger enhanced Ca ( 2+ ) influx in CD5 ( + ) B-1 cells , unlike CD22-deficient splenic B-2 cells , suggesting a relatively limited *role* of in [BCR] signaling in B-1 cells . Positive_regulation BCR CD22 17223015 1703651 CD19 and do not merely *regulate* [BCR] signals independently , but they have their own regulatory network . Positive_regulation BCR CD22 17631277 1775245 Because mediated signal regulation requires phosphorylation of CD22 by Lyn that localizes in lipid rafts and is *activated* by [BCR] , synthetic glycan ligand regulates localization of CD22 crucial for signal regulation . Positive_regulation BCR CD22 18024433 1851804 Here we address the requirement of CD22 for SHP-1 recruitment and BCR regulation upon [BCR] ligation by antigen , which *induces* much stronger phosphorylation than anti-Ig Ab does . Positive_regulation BCR CD22 18024433 1851813 We demonstrate that the mutant in which both Tyr ( 843 ) and Tyr ( 863 ) are replaced by phenylalanine ( CD22F5/6 ) recruits SHP-1 and *regulates* [BCR] signaling upon stimulation with antigen but not anti-Ig Ab . Positive_regulation BCR CD22 9371816 466171 Ligation of CD19 and in vivo is likely to positively and negatively *regulate* [BCR] signaling , respectively , because CD19 crosslinking was more efficient than BCR crosslinking at inducing Vav phosphorylation . Positive_regulation BCR EPHB2 11466342 839898 Although both CD72 and [BCR] *induced* Btk dependent activation , CD72 mediated proliferation is more resistant to blocking of ERK activity than that of BCR , as shown by the proliferation response of B cells treated with PD98059 and dibutyryl cAMP , agents that inhibit ERK activity . Positive_regulation BCR EPHB2 12008033 940695 We compared the [BCR] *induced* intracellular [ Ca2+ ] transient , protein tyrosine phosphorylation and phosphorylation , furthermore , the activation of Elk-1 and CREB transcription factors . Positive_regulation BCR EPHB2 20176802 2222125 Ras activation of *restores* impaired tonic [BCR] signaling and rescues immature B cell differentiation . Positive_regulation BCR FAS 9680367 521039 *mediated* modulation of [Bcr/Abl] in chronic myelogenous leukemia results in differential effects on apoptosis . Positive_regulation BCR GPR115 16291747 1509823 We performed in vitro kinase activity assays and show that [BCR-ABL] also leads to increased p110gamma activity and that this activation *requires* both and Ras signaling . Positive_regulation BCR GPR132 16291747 1509812 We performed in vitro kinase activity assays and show that [BCR-ABL] also leads to increased p110gamma activity and that this activation *requires* both and Ras signaling . Positive_regulation BCR GPR87 16291747 1509892 We performed in vitro kinase activity assays and show that [BCR-ABL] also leads to increased p110gamma activity and that this activation *requires* both and Ras signaling . Positive_regulation BCR JAG1 19592644 2111971 We have discovered that [BCR] *stimulation* with either viral or activating Abs in the context of the acute phase cytokine IL-21 can induce the secretion of substantial amounts of GrB by human B cells . Positive_regulation BCR PECAM1 23233201 2724494 is *involved* in [BCR/ABL] signaling and may downregulate imatinib induced apoptosis of Philadelphia chromosome positive leukemia cells . Positive_regulation BCR TGM2 19840940 2170046 *regulates* the GTPase activating activity of [Bcr] . Positive_regulation BCR TGM2 21310073 2393314 *regulates* [Bcr] by direct binding to its GAP domain . Positive_regulation BCR TLR7 19890051 2165949 After coculture of autoreactive B cells that recognize self-Ag small nuclear ribonucleoprotein particles with activated pDCs , we found that pDCs significantly enhance autoreactive B cell proliferation , autoantibody production , and survival in *response* to and [BCR] stimulation . Positive_regulation BCR TLR7 22652800 2610604 Dual [BCR/TLR] engagement *induces* CSR to all Ig isotypes , as directed by cytokines , while engagement alone induces marginal CSR . Positive_regulation BCRP1 TNF 19074973 2035858 , unlike IL-6 , markedly reduced bile salt export pump mRNA levels and *increased* [BCRP] protein expression . Positive_regulation BCRP2 TNF 19074973 2035854 , unlike IL-6 , markedly reduced bile salt export pump mRNA levels and *increased* [BCRP] protein expression . Positive_regulation BCRP3 TNF 19074973 2035855 , unlike IL-6 , markedly reduced bile salt export pump mRNA levels and *increased* [BCRP] protein expression . Positive_regulation BCRP4 TNF 19074973 2035856 , unlike IL-6 , markedly reduced bile salt export pump mRNA levels and *increased* [BCRP] protein expression . Positive_regulation BCRP5 TNF 19074973 2035857 , unlike IL-6 , markedly reduced bile salt export pump mRNA levels and *increased* [BCRP] protein expression . Positive_regulation BCRP6 TNF 19074973 2035859 , unlike IL-6 , markedly reduced bile salt export pump mRNA levels and *increased* [BCRP] protein expression . Positive_regulation BCRP7 TNF 19074973 2035860 , unlike IL-6 , markedly reduced bile salt export pump mRNA levels and *increased* [BCRP] protein expression . Positive_regulation BCRP8 TNF 19074973 2035861 , unlike IL-6 , markedly reduced bile salt export pump mRNA levels and *increased* [BCRP] protein expression . Positive_regulation BCRP9 TNF 19074973 2035862 , unlike IL-6 , markedly reduced bile salt export pump mRNA levels and *increased* [BCRP] protein expression . Positive_regulation BDKRB1 EPHB2 17804409 1817446 Increased iNOS activity was dependent on [B1R] *activation* of the MAPK . Positive_regulation BDKRB1 IL1B 10362533 620054 [BDKRB1] mRNA expression in MH-S cells was *increased* by ( 1 , 3 , and 10 ng/ml ) in a time dependent manner , peaking at 3-4 h by 100-1000 fold . Positive_regulation BDKRB1 IL1B 11408528 825960 Despite [B1R] *up-regulation* in A549 human lung epithelial cells by desArg10KD or individually , these factors did not act synergistically in this cell line . Positive_regulation BDKRB1 TNF 17931716 1849232 Preliminary experiments mostly based on a novel cellular model , rabbit dermis fibroblasts , showed that etanercept inhibited *induced* [B(1)R] expression ( [ ( 3 ) H ] Lys-des-Arg ( 9 ) -BK binding ) , but that DSP also inhibited cytokine induced B(1)R upregulation with less selectivity . Positive_regulation BDKRB1 TNF 21600945 2454183 Data suggest that the increased expression of [B1R] by TPM in A549 cells is *mediated* by oxidative stress , IL-1ß and NF-kB but not by cyclooxygenases or . Positive_regulation BDKRB2 ITGB2 23275384 2737584 [B2R] stimulation *induced* activation in early outgrowth cells of healthy subjects , but not in early outgrowth cells of CAD patients . Positive_regulation BDNF EFNB1 21653848 2442134 Phosphorylation of , but not EphB2 , was *induced* by both conditioning and [BDNF] application and was inhibited by postsynaptic injections of ephrin-B antibody . Positive_regulation BDNF EPHB2 11880483 919394 [Brain derived neurotrophic factor] induces long-term potentiation in intact adult hippocampus : *requirement* for activation coupled to CREB and upregulation of Arc synthesis . Positive_regulation BDNF EPHB2 12504600 1026938 We observed , both in vitro and in vivo , that exogenous [BDNF] *induced* a rapid activation of , a signaling kinase important in the development of acute pain . Positive_regulation BDNF EPHB2 15469046 1305870 We observed that the signalling *regulates* the [brain derived neurotrophic factor (BDNF)] expression in DRG neurons in both conditions . Positive_regulation BDNF EPHB2 15650750 1364054 Influx of calcium , mediated either by L-type voltage-sensitive calcium channels or glutamate receptors , is associated with the suppression of [brain derived neurotrophic factor (BDNF)] *activation* of Ras and its effectors and Akt . Positive_regulation BDNF EPHB2 19557513 2182716 However , the neurite outgrowth activity and the NGF and [BDNF] release induced by 4-O-methylhonokiol are *suppressed* by an inhibitor . Positive_regulation BDNF EPHB2 20444938 2294134 In addition , ghrelin increased the level of *dependent* [brain derived neurotrophic factor] expression and decreased the level of pronerve growth factor expression . Positive_regulation BDNF EPHB2 20649843 2368061 These results suggest that , by recruiting cyclic GMP and PKG , neuronal nitric oxide synthase derived nitric oxide plays a novel and essential role in RAR signaling leading to *dependent* [BDNF] up-regulation in midbrain dopaminergic neurons . Positive_regulation BDNF EPHB2 20868677 2337196 However , the neurite outgrowth , and NGF and [BDNF] release induced by obovatol were *prevented* by an inhibitor . Positive_regulation BDNF EPHB2 21259048 2409476 Levels of [BDNF] expression in the *presence* of the inhibitor were lower that in unstimulated and untreated controls , indicating that Erk activation is required to maintain baseline levels of BDNF . Positive_regulation BDNF EPHB2 21411668 2404879 Aging and a peripheral immune challenge interact to reduce mature [brain derived neurotrophic factor] and *activation* of TrkB , PLCgamma1 , and in hippocampal synaptoneurosomes . Positive_regulation BDNF EPHB2 21486081 2428398 Hesperetin also stimulated the activation of Akt , , and CREB as well as *induced* [brain derived neurotrophic factor] , PPAR? coactivator 1a ( PGC-1a ) , and seladin-1 ( selective Alzheimer 's disease indicator-1 ) via both ER and TrkA in the cells . Positive_regulation BDNF EPHB2 21653848 2442135 Phosphorylation of ephrin-B1 , but not , was *induced* by both conditioning and [BDNF] application and was inhibited by postsynaptic injections of ephrin-B antibody . Positive_regulation BDNF EPHB2 22309829 2565318 Taken together , EP1 and EP4 receptor subtypes , PKA , and CREB signaling pathways as well as NGF are *involved* in PGE2 induced [BDNF] synthesis in DRG neurons . Positive_regulation BDNF EPHB2 22820234 2660320 Curcumin produces antidepressant effects via activating *dependent* [brain derived neurotrophic factor] expression in the amygdala of mice . Positive_regulation BDNF EPHB2 22921460 2697511 Here we report that [BDNF] up-regulation in the primary afferent neurons in the dorsal root ganglia (DRG) in a rat model of colitis is *mediated* by the activation of endogenous extracellular signal regulated protein kinase ( ) 5 and by nerve growth factor (NGF) retrograde signaling . Positive_regulation BDNF EPHB2 23035088 2684521 Extinction of aversive memories associated with morphine withdrawal requires *mediated* epigenetic regulation of [brain derived neurotrophic factor] transcription in the rat ventromedial prefrontal cortex . Positive_regulation BDNF IL1B 16441896 1527873 COX-inhibitors ( indomethacin and NS-398 ) markedly decreased *stimulated* secretion of [BDNF] , but not IL-1beta stimulated NGF secretion . Positive_regulation BDNF IL1B 16621158 1598393 In the present study , we have shown that *increased* [BDNF] mRNA expression in hypothalamic neuron enriched cultures whereas it reduced this expression in mixed cultures , i.e. containing astrocytes and neurons . Positive_regulation BDNF IL1B 17708459 1783101 On the other hand , TNFalpha , , and IFN-gamma did not affect DPP-IV activity but significantly *increased* the cellular expression and the basolateral secretion of [BDNF] . Positive_regulation BDNF IL1B 18727839 1979959 In cultured human nucleus pulposus cells , stimulation with *led* to significant increases in NGF and [BDNF] gene expression ( P < 0.05 ) . Positive_regulation BDNF MAP2K6 10648867 662265 These results thus suggest that both [BDNF dependent and -independent] expressions of GABA(A) receptor subunits *require* the activation of and the mitogen activated protein kinase (MAPK) pathway . Positive_regulation BDNF MAP2K6 11885780 894124 The inductions of [BDNF] and NGF were also *blocked* by inhibitors of p38 and , as well as by the inhibition of NF-kappaB with a decoy DNA sequence . Positive_regulation BDNF NT5E 12069900 955663 significantly *augments* [BDNF] protein production , which is also reversed by K252a . Positive_regulation BDNF NT5E 8869564 389309 Recombinant [BDNF] was *detected* at concentrations as low as 10 pg/ml , whereas the EIA did not detect NT-3 , , or NGF at concentrations as high as 100 ng/ml . Positive_regulation BDNF PLAT 10215917 608240 Together these results suggest that *activation* of by [BDNF] may contribute to structural changes associated with neuronal development or synaptic plasticity . Positive_regulation BDNF PLAT 18563704 1940823 These results support the hypothesis that *mediates* synaptic activation of [BDNF] by demonstrating that tPA , plasminogen , and proBDNF colocalize in DCGs in spines , where these neuromodulators can undergo activity dependent release and then interact and/or mediate changes that influence synaptic efficacy . Positive_regulation BDNF PLAU 16620701 1551317 Maximal activation of and PAI-1 expression in HUVECs was *induced* by 100 ng/ml [BDNF] , while effects of 200 ng/ml and 400 ng/ml BDNF were slightly reduced in comparison with with those of 100 ng/ml. uPAease activity for BDNF was also increased by BDNF in a dose dependent manner . Positive_regulation BDNF TNF 15710474 1373498 and interleukin-6 *regulate* secretion of [brain derived neurotrophic factor] in human monocytes . Positive_regulation BDNF TNF 15710474 1373502 IL-6 and specifically *enhanced* [BDNF] secretion in monocytes , whereas typical Th1- and Th2-cytokines did not show any effect . Positive_regulation BDNF TNF 17708459 1783099 On the other hand , , IL-1beta , and IFN-gamma did not affect DPP-IV activity but significantly *increased* the cellular expression and the basolateral secretion of [BDNF] . Positive_regulation BDNF TNF 18040799 1669135 *Up-regulation* of [BDNF] in astrocytes by : a case for the neuroprotective role of cytokine . Positive_regulation BDNF TNF 18040799 1669142 Activation of NF-kappaB by TNF-alpha and inhibition of *induced* [BDNF] expression by Deltap65 ( a dominant negative mutant ) and NEMO binding domain peptide ( an inhibitor of NF-kappaB ) suggests that TNF-alpha induces BDNF expression through the activation of NF-kappaB . Positive_regulation BDNF TNF 18040799 1669152 Among three MAP kinases , *induced* [BDNF] up-regulation was sensitive only to inhibitors of ERK MAP kinase . Positive_regulation BDNF TNF 20690185 2368107 IL-1ß and *stimulated* the gene expression of VEGF , NGF , and [BDNF] in nucleus pulposus ( NP ) cells isolated from patient tissues . Positive_regulation BECN1 CAPN8 19778902 2202867 We also found that ras activates a GTPase RhoA , that RhoA promotes activation of a protease calpain , and that *triggers* degradation of [Beclin-1] , a critical mediator of autophagy , in these cells . Positive_regulation BECN1 CAPN8 21490676 2418054 Altogether , our results provide original evidence for *mediated* cleavage of [Beclin-1] and deregulation of basal autophagy in the rat retina that has undergone ocular ischemia/reperfusion injury . Positive_regulation BECN1 CAPN8 22496897 2583730 The decrease in Beclin 1 following TMZ-Se treatment were rescued by the calpain inhibitors and the *mediated* degradation of [Beclin1] had no effect on autophagy but promoted apoptosis in cells treated with TMZ-Se . Positive_regulation BECN1 DAPK1 22170404 2563273 The activation of both AMPK and prompted the phosphorylation of p53 and *enhanced* [Beclin 1] expression . Positive_regulation BECN1 TLR7 18772134 1985790 signaling *enhances* the interaction of MyD88 and Trif with [Beclin 1] , and reduces the binding of Beclin 1 to Bcl-2 . Positive_regulation BECN1 TNF 16942488 1609461 *induced* MAPLC-3 mRNA expression through c-jun N-terminal kinase and protein kinase B pathways and induced [Beclin-1] protein expression through the c-jun N-terminal kinase pathway . Positive_regulation BECN1 TNF 22869322 2682528 In addition , acylated ghrelin reduced the basal expression of the autophagy related genes ATG5 and ATG7 , while desacyl ghrelin inhibited the *induced* increase of ATG5 , [BECN1] and ATG7 expression . Positive_regulation BGLAP CABP4 16199532 1483142 Also , [osteocalcin] , a highly expressed in bone , dose-dependently *stimulated* GPRC6A activity in the presence of calcium but inhibited the calcium dependent activation of CASR . Positive_regulation BGLAP EPHB2 14602722 1200294 Finally , we show that Notch and activation are *essential* for Runx2 DNA binding activity and [osteocalcin] gene expression in C4-2B cells in response to osteogenic induction . Positive_regulation BGLAP FOXO1 21471200 2433547 In this study , we determined the molecular mechanisms whereby forkhead transcription factor , a key downstream signaling molecule of insulin-like growth factor 1 (IGF1)/insulin actions , *regulates* Runx2 activity and expression of the mouse osteocalcin gene 2 ( [Bglap2] ) in osteoblasts in vitro . Positive_regulation BGLAP IL1B 12375736 996723 *regulates* cellular proliferation , prostaglandin E2 synthesis , plasminogen activator activity , [osteocalcin] production , and bone resorptive activity of the mouse calvarial bone cells . Positive_regulation BGLAP NT5E 18980528 1983312 We examined how *regulates* the mRNA expression of bone/cementum related proteins ( alkaline phosphatase [ ALPase ] , osteopontin [ OPN ] , [osteocalcin] [ OC ] , and bone morphogenetic protein [ BMP]-2 ) in cultures of HPL cells . Positive_regulation BGLAP RARB 9113387 426009 These results suggested that the inhibitory effect of RA on the mineralization of human osteoblasts is mediated by the activation of RAR alpha and/or and that RAR gamma preferentially *regulates* the expression of [osteocalcin] without influence on mineralization . Positive_regulation BGN CTGF 19433344 2128251 Our studies documented that and FGF2 significantly *enhanced* the expression of collagens I & III , [biglycan] and periostin in tissue engineered regenerates after 4 weeks compared to untreated controls . Positive_regulation BGN EPHB2 20213272 2259552 Pharmacological inhibition of and p38 *blocked* TGF-beta mediated GAG elongation and expression of [biglycan] whereas inhibition of JNK had no effect . Positive_regulation BGN IL1B 19605353 2123846 Here we show that in macrophages , soluble [biglycan] *induces* the NLRP3/ASC inflammasome , activating caspase-1 and releasing mature without the need for additional costimulatory factors . Positive_regulation BGN IL1B 9689917 522946 In contrast , *had* a weak inhibitory effect on both decorin and [biglycan] expression . Positive_regulation BID ARSA 23532686 2772537 B=ASA+ER-DP 25 mg/200 mg [BID+omeprazole] ( Prilosec® ) 80 mg once daily ( QD ) *following* alone for 7 days ; Positive_regulation BID FAS 10713706 676261 We provide evidence that both , radiation and stimulation , *induce* the rapid activation of caspase-8 and [BID] followed by apoptosis in Jurkat T-cells . Positive_regulation BID FAS 10950869 723564 engagement *results* in the cleavage of cytosolic [BID] to truncated tBID , which translocates to mitochondria . Positive_regulation BID FAS 12529377 1079127 In human KB epithelial cells expressing the caspase-resistant mutant crBAP31 , stimulation *resulted* in cleavage of [BID] and insertion of BAX into mitochondrial membrane , but subsequent oligomerization of BAX and BAK , egress of cytochrome c to the cytosol , and apoptosis were impaired . Positive_regulation BID FAS 21072056 2382886 In this study , we have identified a native complex containing caspase-8 and BID on the mitochondrial membrane , and showed that death receptor activation by or tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) *induced* the cleavage of [BID] ( tBID formation ) within this complex . Positive_regulation BID TNF 9873064 583456 treatment *induced* a caspase mediated cleavage of cytosolic , inactive p22 [BID] at internal Asp sites to yield a major p15 and minor p13 and p11 fragments . Positive_regulation BID TNFSF10 11360196 816772 In addition , *initiates* the activation of caspases , the loss of mitochondrial transmembrane potential ( Deltapsi ( m ) ) , the cleavage of [BID] , and the redistribution of mitochondrial cytochrome c . Positive_regulation BID TNFSF10 11911810 924232 also *induced* cleavage of [BID] , which was also abolished by Bcl-2 and Bcl-xL . Positive_regulation BID TNFSF10 12154014 971659 We find that CK2 inhibits induced caspase-8 *mediated* cleavage of [BID] , thereby reducing the formation of tBID . Positive_regulation BID TNFSF10 12592338 1060368 We did not observe a protective effect of Bcl-X ( L ) or Bcl-2 against the cytotoxic activity of TRAIL , even though *induced* cleavage of [BID] . Positive_regulation BIK TNF 23496259 2803952 However , inhibited the mRNA expression of the Per2 gene , as well as Dbp , Hlf , and Tef , but *enhanced* the mRNA expression of [E4bp4] . Positive_regulation BIRC2 TNF 10224110 609995 PG490 also blocked *mediated* induction of c-IAP2 ( hiap-1 ) and [c-IAP1] ( hiap-2 ) , members of the inhibitor of apoptosis (IAP) family . Positive_regulation BIRC2 TNF 10751398 698704 Involvement of two NF-kappa B binding elements in alpha - , CD40- , and epstein-barr virus latent membrane protein 1-mediated *induction* of the cellular [inhibitor of apoptosis protein 2] gene . Positive_regulation BIRC2 TNF 10751398 698705 Among the antiapoptotic genes , cellular [inhibitor of apoptosis protein 2] ( c-IAP2/HIAP-1/MIHC ) is originally identified as a molecule recruited to the tumor necrosis factor (TNF) receptor complex , and its expression is preferentially *up-regulated* by and other stimuli activating NF-kappaB . Positive_regulation BIRC2 TNF 11473640 841717 In *response* to , expression of [c-IAP1] and c-IAP2 was induced in HeLa cells and ECV304 endothelial cells , but not in mesangial cells . Positive_regulation BIRC2 TNF 11877450 937177 Also , treatment of cells with kamebakaurin prevented the *induced* expression of antiapoptotic NF-kappaB target genes encoding [c-IAP1] ( hiap-2 ) and c-IAP2 ( hiap-1 ) , members of the inhibitor of apoptosis family , and Bfl-1/A1 , a prosurvival Bcl-2 homologue , and augmented the TNF-alpha induced caspase 8 activity , thereby resulting in sensitizing MCF-7 cells to TNF-alpha induced apoptosis . Positive_regulation BIRC2 TNF 12603340 1062481 Western blotting analysis indicated that alone *increased* [c-IAP1] protein levels , whereas CH11 alone had no effect . Positive_regulation BIRC2 TNF 15851579 1399555 Overexpression of mutant IkappaB blocked *induced* TRAF-1 , TRAF-2 , [c-IAP1] , c-IAP2 , c-FLIP , and A1 gene expression and downregulated TRAF-1 protein levels . Positive_regulation BIRC2 TNF 15861135 1404151 *induced* [c-IAP1/TRAF2] complex translocation to a Ubc6 containing compartment and TRAF2 ubiquitination . Positive_regulation BIRC2 TNF 17133355 1677744 In human endothelial cells , *induced* [c-IAP1] and c-IAP2 , but not XIAP and TIAP/Survivin , at the transcriptional level . Positive_regulation BIRC2 TNF 17133355 1677747 In contrast , extracellular signal regulated kinase , p38 MAP kinase , and c-Jun N-terminal kinase were activated after stimulation with TNF-alpha , and inhibition of each kinase by PD098059 , SB203580 , curcumin , or SP600125 substantially attenuated the *induced* [c-IAP1] and c-IAP2 expression . Positive_regulation BIRC2 TNF 17611628 1768633 In vitro , luteolin sensitized colonic epithelial HT29 cells to TNFalpha induced apoptosis , caspase 3 activation , DNA fragmentation and reduced *induced* [C-IAP1] , C-IAP2 and COX-2 gene expression . Positive_regulation BIRC2 TNF 20356846 2266538 signaling , but not TWEAK ( TNF-like weak inducer of apoptosis ) -triggered cIAP1 ( cellular inhibitor of apoptosis protein 1 ) degradation , *requires* [cIAP1] RING dimerization and E2 binding . Positive_regulation BIRC2 TNF 21820422 2490440 Triptolide also abrogated *induced* expression of cell survival proteins ( XIAP , Bcl-x ( L ) , Bcl-2 , survivin , [cIAP-1] and cIAP-2 ) , cell proliferative proteins ( cyclin D1 , c-myc and cyclooxygenase-2 ) , and metastasis proteins ( ICAM-1 and MMP-9 ) . Positive_regulation BIRC2 TNFSF10 11846395 912452 IFN-gamma inhibition of *induced* [IAP-2] upregulation , a possible mechanism of IFN-gamma enhanced TRAIL induced apoptosis . Positive_regulation BIRC2 TNFSF10 11846395 912453 Our findings suggest that IFN-gamma may sensitize HeLa cells to TRAIL induced apoptosis by preventing *induced* [IAP-2] upregulation , and IFN-gamma may play a role in anticancer therapy of TRAIL protein through such mechanism . Positive_regulation BIRC3 TNF 10224110 609996 PG490 also blocked mediated *induction* of [c-IAP2] ( hiap-1 ) and c-IAP1 ( hiap-2 ) , members of the inhibitor of apoptosis (IAP) family . Positive_regulation BIRC3 TNF 11359809 816343 *induced* expression of the antiapoptotic protein [c-IAP2] ( cytoplasmic inhibitor of apoptosis protein 2 ) , and was blocked in the presence of a p38 MAPK inhibitor , which also induced caspase dependent , TNF mediated apoptosis in U937 cells . Positive_regulation BIRC3 TNF 11473640 841718 In *response* to , expression of c-IAP1 and [c-IAP2] was induced in HeLa cells and ECV304 endothelial cells , but not in mesangial cells . Positive_regulation BIRC3 TNF 11877450 937178 Also , treatment of cells with kamebakaurin prevented the *induced* expression of antiapoptotic NF-kappaB target genes encoding c-IAP1 ( hiap-2 ) and [c-IAP2] ( hiap-1 ) , members of the inhibitor of apoptosis family , and Bfl-1/A1 , a prosurvival Bcl-2 homologue , and augmented the TNF-alpha induced caspase 8 activity , thereby resulting in sensitizing MCF-7 cells to TNF-alpha induced apoptosis . Positive_regulation BIRC3 TNF 15665002 1382032 APC and thrombin both triggered PAR1 mediated responses in endothelial cells including expression of antiapoptotic ( *induced* a20 and [iap-1] ) and chemokine ( interleukin-8 (il-8) and cxcl3 ) genes , but again , APC was approximately 10 ( 4 ) -fold less potent than thrombin . Positive_regulation BIRC3 TNF 15851579 1399552 TRAF-1 , c-FLIP , and to a lesser extent [c-IAP2] protein levels were *increased* by in a time dependent manner , whereas c-IAP1 , survivin , Bcl-x ( L ) , and TRAF-2 protein levels were not influenced by TNF-alpha treatment at any time point tested . Positive_regulation BIRC3 TNF 16154993 1475769 Our results suggest that LPS and *induced* [c-IAP2] expression was regulated by calmodulin (CaM) through the activation of calmodulin dependent protein kinase-II ( CaMKII ) . Positive_regulation BIRC3 TNF 16154993 1475774 Taken together , these results suggest that LPS- and *induced* [c-IAP2] expression and its associated antiapoptotic survival signals in THP-1 cells are regulated selectively by CaM/CaMKII through NF-kappaB activation . Positive_regulation BIRC3 TNF 17133355 1677745 In human endothelial cells , *induced* c-IAP1 and [c-IAP2] , but not XIAP and TIAP/Survivin , at the transcriptional level . Positive_regulation BIRC3 TNF 17133355 1677748 In contrast , extracellular signal regulated kinase , p38 MAP kinase , and c-Jun N-terminal kinase were activated after stimulation with TNF-alpha , and inhibition of each kinase by PD098059 , SB203580 , curcumin , or SP600125 substantially attenuated the *induced* c-IAP1 and [c-IAP2] expression . Positive_regulation BIRC3 TNF 17611628 1768634 In vitro , luteolin sensitized colonic epithelial HT29 cells to TNFalpha induced apoptosis , caspase 3 activation , DNA fragmentation and reduced *induced* C-IAP1 , [C-IAP2] and COX-2 gene expression . Positive_regulation BIRC3 TNF 21279667 2419774 We demonstrate that in the absence of p65 , *induced* [cIAP2] expression is significantly reduced while the levels of Bcl-2 , Bcl-xL and Survivin are not affected . Positive_regulation BIRC3 TNF 21820422 2490441 Triptolide also abrogated *induced* expression of cell survival proteins ( XIAP , Bcl-x ( L ) , Bcl-2 , survivin , cIAP-1 and [cIAP-2] ) , cell proliferative proteins ( cyclin D1 , c-myc and cyclooxygenase-2 ) , and metastasis proteins ( ICAM-1 and MMP-9 ) . Positive_regulation BIRC3 TNF 23250032 2737208 selectively *induced* [Birc3] in beta cells , which in turn was sufficient to drive and potentiate NF-?B reporter activity . Positive_regulation BIRC3 TNF 23597429 2789711 Here , we show that pro-inflammatory cytokine *induced* the up-regulation of [c-IAP2] in the potential metastatic nasopharyngeal carcinoma (NPC) cells in a dose- and time dependent manner . Positive_regulation BIRC3 TNFSF10 17613437 1768779 Reduction of *induced* Mcl-1 and [cIAP2] by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL induced death . Positive_regulation BIRC3 TNFSF10 17613437 1768783 *induced* expression of antiapoptotic Mcl-1 and [cIAP2] through activation of NF-kappaB . Positive_regulation BLNK EPHB2 19268704 2063206 Here we show for the first time that cross linking of CD58 induces protein tyrosine phosphorylation of [BLNK] , Syk and PLCgamma , and *activation* of and Akt/PKB . Positive_regulation BLNK NGFR 22880054 2641709 signaling *induces* phosphorylation of [BLNK] , a marker of Syk activation . Positive_regulation BMF MAP2K6 22258404 2544895 In this study , we show that [Bmf] is *regulated* at the post-translational level by mutant signaling . Positive_regulation BMI1 ID1 20697353 2335479 In this study , we examined the effect of Id1 on polycomb group ( PcG ) proteins , which are crucial epigenetic gene silencers , and found that *regulated* the expression of Mel-18 and [Bmi-1] , both of which belong to polycomb repressive complex 1 . Positive_regulation BMI1 ID1 24572994 2924796 and NF-?B *promote* the generation of CD133+ and [BMI-1+] keratinocytes and the growth of xenograft tumors in mice . Positive_regulation BMI1 ID1 24572994 2924798 and NF-?B *regulate* the expression of CD133 and [BMI-1] in an additive or synergistic manner in OSCC , which is associated with the generation of naïve and self-renewable keratinocytes and initiate the growth of xenograft tumors in vivo . Positive_regulation BMP1 CTGF 24112732 2852616 Importantly , Noggin treatment inhibited endogenous and BMP induced CCN2 expression , verifying that expression in developing tooth germs *requires* [BMP] signalling . Positive_regulation BMP1 EPHB2 22056560 2513915 We therefore focused on the relationship between Osterix and Erk1/2 during osteoblast differentiation because [BMP] signaling *induces* activation in osteoblasts . Positive_regulation BMP1 EPHB2 22072425 2585417 Based on this work , we conclude that extracellular matrix and [BMP] regulation of RUNX2 phosphorylation and transcriptional activity in osteoblasts is predominantly *mediated* by rather than p38 MAPKs . Positive_regulation BMP1 EPHB2 22687552 2643706 [PCP] *induced* the phosphorylation of , JNK , and p38 , and the nuclear translocation of NF-?B p50/p65 , which are the main signaling molecules downstream from TLR4 . Positive_regulation BMP1 ID1 17374642 1720663 These findings suggest that Twist-1 can act as an inhibitor of BMP signaling , and can *regulate* [BMP] signaling through a positive feedback loop repressing Twist-1 function . Positive_regulation BMP1 KCP 15793581 1390286 Unlike chordin , *enhances* [BMP] signaling in a paracrine manner . Positive_regulation BMP1 MSX1 9846381 553856 BMPs may in some cases trigger the cell death cascade , while gene products *regulate* [Bmp] expression . Positive_regulation BMP1 OSR1 16243309 1483699 In explant cultures , [Bmp] *activation* of , the earliest known gene expressed in the intermediate mesoderm , is blocked by cyclohexamide , indicating that the activation of Odd-1 by Bmp signaling is translation dependent . Positive_regulation BMP1 PLAU 11592634 869702 To gain a better insight into the *role* of in Pneumocystis carinii ( P. carinii ) pneumonia ( [PCP] ) , we evaluated PA production in alveolar macrophages ( AMs ) obtained from rats with steroid induced PCP . Positive_regulation BMP1 TP63 19717565 2152061 Here we report a previously uncovered *role* of in controlling [bone morphogenetic protein (BMP)] signaling , which is required for maintaining low expression levels of several non-epidermal genes . Positive_regulation BMP10 CTGF 24112732 2852624 Importantly , Noggin treatment inhibited endogenous and BMP induced CCN2 expression , verifying that expression in developing tooth germs *requires* [BMP] signalling . Positive_regulation BMP10 EPHB2 22056560 2513923 We therefore focused on the relationship between Osterix and Erk1/2 during osteoblast differentiation because [BMP] signaling *induces* activation in osteoblasts . Positive_regulation BMP10 EPHB2 22072425 2585425 Based on this work , we conclude that extracellular matrix and [BMP] regulation of RUNX2 phosphorylation and transcriptional activity in osteoblasts is predominantly *mediated* by rather than p38 MAPKs . Positive_regulation BMP10 ID1 17374642 1720671 These findings suggest that Twist-1 can act as an inhibitor of BMP signaling , and can *regulate* [BMP] signaling through a positive feedback loop repressing Twist-1 function . Positive_regulation BMP10 KCP 15793581 1390294 Unlike chordin , *enhances* [BMP] signaling in a paracrine manner . Positive_regulation BMP10 MSX1 9846381 553872 BMPs may in some cases trigger the cell death cascade , while gene products *regulate* [Bmp] expression . Positive_regulation BMP10 OSR1 16243309 1483707 In explant cultures , [Bmp] *activation* of , the earliest known gene expressed in the intermediate mesoderm , is blocked by cyclohexamide , indicating that the activation of Odd-1 by Bmp signaling is translation dependent . Positive_regulation BMP10 TP63 19717565 2152069 Here we report a previously uncovered *role* of in controlling [bone morphogenetic protein (BMP)] signaling , which is required for maintaining low expression levels of several non-epidermal genes . Positive_regulation BMP15 CTGF 24112732 2852617 Importantly , Noggin treatment inhibited endogenous and BMP induced CCN2 expression , verifying that expression in developing tooth germs *requires* [BMP] signalling . Positive_regulation BMP15 EPHB2 22056560 2513916 We therefore focused on the relationship between Osterix and Erk1/2 during osteoblast differentiation because [BMP] signaling *induces* activation in osteoblasts . Positive_regulation BMP15 EPHB2 22072425 2585418 Based on this work , we conclude that extracellular matrix and [BMP] regulation of RUNX2 phosphorylation and transcriptional activity in osteoblasts is predominantly *mediated* by rather than p38 MAPKs . Positive_regulation BMP15 ID1 17374642 1720664 These findings suggest that Twist-1 can act as an inhibitor of BMP signaling , and can *regulate* [BMP] signaling through a positive feedback loop repressing Twist-1 function . Positive_regulation BMP15 KCP 15793581 1390287 Unlike chordin , *enhances* [BMP] signaling in a paracrine manner . Positive_regulation BMP15 MSX1 9846381 553858 BMPs may in some cases trigger the cell death cascade , while gene products *regulate* [Bmp] expression . Positive_regulation BMP15 OSR1 16243309 1483700 In explant cultures , Bmp activation of Odd skipped related 1 (Odd-1) , the earliest known gene expressed in the intermediate mesoderm , is blocked by cyclohexamide , indicating that the *activation* of by [Bmp] signaling is translation dependent . Positive_regulation BMP15 TP63 19717565 2152062 Here we report a previously uncovered *role* of in controlling [bone morphogenetic protein (BMP)] signaling , which is required for maintaining low expression levels of several non-epidermal genes . Positive_regulation BMP2 CTGF 24112732 2852618 Importantly , Noggin treatment inhibited endogenous and BMP induced CCN2 expression , verifying that expression in developing tooth germs *requires* [BMP] signalling . Positive_regulation BMP2 EPHB2 10679278 668891 These results indicate that is *involved* in [BMP-2] induced osteoblast differentiation . Positive_regulation BMP2 EPHB2 22056560 2513917 We therefore focused on the relationship between Osterix and Erk1/2 during osteoblast differentiation because [BMP] signaling *induces* activation in osteoblasts . Positive_regulation BMP2 EPHB2 22072425 2585404 Significantly , in the presence of AA , [BMP2/7] synergistically stimulated RUNX2 S319 phosphorylation and transcriptional activity without affecting total RUNX2 and this response was totally *dependent* on activity . Positive_regulation BMP2 EPHB2 22072425 2585419 Based on this work , we conclude that extracellular matrix and [BMP] regulation of RUNX2 phosphorylation and transcriptional activity in osteoblasts is predominantly *mediated* by rather than p38 MAPKs . Positive_regulation BMP2 FOXA1 17513867 1762026 The bone-protective effect was attributable to induction of bone morphogenetic protein-2 through Src kinase dependent estrogen receptor activation and is *required* for resveratrol induced estrogen receptor dependent [bone morphogenetic protein-2] expression . Positive_regulation BMP2 ID1 12296825 990966 [BMP-2] *induces* transcription of , an inhibitor for myogenesis , within 1 h in the cells . Positive_regulation BMP2 ID1 16247476 1518156 We show that [BMP-2] *induces* expression in lung cancer cell lines through its activation of Smad-1/5 , which is dependent on cell culture conditions . Positive_regulation BMP2 ID1 16247476 1518162 In serum-free medium , [BMP-2] *induced* significantly less Smad-1/5 activation and expression , and produced significant growth inhibition . Positive_regulation BMP2 ID1 16647687 1557348 Sulfation is required for [bone morphogenetic protein 2-dependent] *induction* . Positive_regulation BMP2 ID1 17374642 1720665 These findings suggest that Twist-1 can act as an inhibitor of BMP signaling , and can *regulate* [BMP] signaling through a positive feedback loop repressing Twist-1 function . Positive_regulation BMP2 ID1 21880603 2486784 Both VEGF and [BMP2] could *induce* the overexpression of gene which significantly promoted tube formation in vitro and increase the amount of blood vessels in the Ad-BMP2-BMSC + Ad-VEGF-EPC group after implantation . Positive_regulation BMP2 ID1 21998639 2493722 Thus , [BMP-2] *induced* gene expression of , Id3 , Dlx2 and Hey1 is endocytosis dependent , whereas BMP-2 induced expression of Id2 , Dlx3 , Zbtb2 and Krt16 is endocytosis independent . Positive_regulation BMP2 IL1B 12925611 1131466 In cartilage explant cultures , and TNF-alpha *increased* [BMP-2] levels both intracellularly and extracellularly . Positive_regulation BMP2 IL1B 16805677 1579603 In this study , we investigated the in vitro effect of avocado and soya unsaponifiables ( ASU ) on the expression of TGF-beta1 , TGF-beta2 , and [bone morphogenetic protein-2 (BMP-2)] by human periodontal ligament (HPL) and human alveolar bone ( HAB ) cells in the *presence* of . Positive_regulation BMP2 IL1B 9213003 441532 alone had no effect on ALP activity , but it significantly *enhanced* [BMP-2-] and -4-induced ALP activity . Positive_regulation BMP2 KCP 15793581 1390288 Unlike chordin , *enhances* [BMP] signaling in a paracrine manner . Positive_regulation BMP2 MAP2K6 23206708 2798605 Increased [BMP-2] mRNA expression mediated by PGE2 was *prevented* by phosphoinositide 3-kinase (PI3K) and Akt inhibitors , but not by a inhibitor . Positive_regulation BMP2 MSX1 12163415 972371 We found that Msx1 expression was restricted to the anterior of the first upper molar site in the palatal mesenchyme and that was *required* for the expression of Bmp4 and [Bmp2] in the mesenchyme and Shh in the medial edge epithelium ( MEE ) in the same region of developing palate . Positive_regulation BMP2 MSX1 9846381 553860 BMPs may in some cases trigger the cell death cascade , while gene products *regulate* [Bmp] expression . Positive_regulation BMP2 NES 23562654 2782997 While high-content-analysis demonstrated that HDACi did not significantly induce caspase-3 or p21 activity , p53-expression was increased by VPA ( 3 mM , 5 mM ) at 48 h. HDACi-exposure *induced* mineralization per cell dose-dependently to a plateau level ( VPA-0.125 mM and TSA-25 nM ) with accompanying increases in mineralization/dentinogenic associated gene expression at 5 days ( DMP-1 , [BMP-2/-4] , ) and 10 days ( DSPP , BMP-2/-4 ) . Positive_regulation BMP2 NT5E 17720554 1807617 Nerve growth factor (NGF) , brain derived neurotrophic factor (BDNF) , neurotrophin (NT)-3 and *increased* the mRNA levels of dentin sialophsphoprotein , alkaline phosphatase , osteopontin , type I collagen and [bone morphogenetic protein-2] and mineral deposition in cultures of HP cells . Positive_regulation BMP2 NT5E 18980528 1983314 We examined how *regulates* the mRNA expression of bone/cementum related proteins ( alkaline phosphatase [ ALPase ] , osteopontin [ OPN ] , osteocalcin [ OC ] , and bone morphogenetic protein [ [BMP]-2] ) in cultures of HPL cells . Positive_regulation BMP2 OSR1 16243309 1483701 In explant cultures , [Bmp] *activation* of , the earliest known gene expressed in the intermediate mesoderm , is blocked by cyclohexamide , indicating that the activation of Odd-1 by Bmp signaling is translation dependent . Positive_regulation BMP2 PTGER2 19233324 2072052 Further , PGE ( 2 ) , and EP4A did not *increase* [BMP2/4] mRNA levels in RC cells , and EP2 induced phosphorylation of p38 MAPK was not eliminated by Noggin . Positive_regulation BMP2 TNF 12925611 1131465 In cartilage explant cultures , IL-1beta and *increased* [BMP-2] levels both intracellularly and extracellularly . Positive_regulation BMP2 TNF 15316669 1286284 IL-1 , but not , can *induce* IL-6 , [bone morphogenic protein 2 (BMP-2)] , and cyclooxygenase ( COX-2 ) expression in SW1353 cells . Positive_regulation BMP2 TNF 16835229 1606482 Pro-inflammatory cytokine *induces* [bone morphogenetic protein-2] in chondrocytes via mRNA stabilization and transcriptional up-regulation . Positive_regulation BMP2 TNF 16835229 1606484 In articular chondrocytes , the inflammatory cytokine *induces* the expression of [bone morphogenetic protein-2 (BMP-2)] , a growth factor known to be involved in the induction of cartilage and bone . Positive_regulation BMP2 TNF 16835229 1606485 In ATDC5 cells , the endogenous [BMP-2] expression was consistently low throughout the process of chondrogenic differentiation , and *induced* BMP-2 expression only after the cells acquired the chondrogenic phenotype . Positive_regulation BMP2 TNF 18433704 1900217 Recently , we described a novel TNF-alpha regulated Msx2-Wnt osteogenic program that regulates arterial calcification in an animal model of type 2 DM . *induces* the osteogenic [bone morphogenetic protein-2 (BMP-2)] , Msx2 , Wnt3a , and Wnt7a mRNAs and leads to increased aortic calcium accumulation . Positive_regulation BMP2 TNF 20067418 2193879 *upregulates* expression of [BMP-2] and BMP-3 genes in the rat dental follicle -- implications for tooth eruption . Positive_regulation BMP2 TNF 20067418 2193882 We found that BMP-3 expression is correlated with the expression of TNF-alpha in the dental follicle and significantly *increased* [BMP-2] and BMP-3 expression in vitro . Positive_regulation BMP2 TNF 20304956 2254868 Indeed , could *induce* [BMP-2] and its receptor ( BMPR1A ) in human skin and primary keratinocytes , and BMP2 could induce EMT features in skin explants and primary keratinocytes . Positive_regulation BMP2 TNF 23765556 2854159 also *increased* mineralisation and the expression of [bone morphogenetic protein 2 (BMP2)] , alkaline phosphatase (ALP) , runt related transcription factor 2 ( RUNX2 ) and collagen type I ( COL I ) during this process . Positive_regulation BMP2 TNF 25228904 2958348 alone *increased* [BMP2] mRNA expression at 6 and 12 h . Positive_regulation BMP2 TP63 19717565 2152063 Here we report a previously uncovered *role* of in controlling [bone morphogenetic protein (BMP)] signaling , which is required for maintaining low expression levels of several non-epidermal genes . Positive_regulation BMP3 CTGF 24112732 2852619 Importantly , Noggin treatment inhibited endogenous and BMP induced CCN2 expression , verifying that expression in developing tooth germs *requires* [BMP] signalling . Positive_regulation BMP3 EPHB2 22056560 2513918 We therefore focused on the relationship between Osterix and Erk1/2 during osteoblast differentiation because [BMP] signaling *induces* activation in osteoblasts . Positive_regulation BMP3 EPHB2 22072425 2585420 Based on this work , we conclude that extracellular matrix and [BMP] regulation of RUNX2 phosphorylation and transcriptional activity in osteoblasts is predominantly *mediated* by rather than p38 MAPKs . Positive_regulation BMP3 ID1 17374642 1720666 These findings suggest that Twist-1 can act as an inhibitor of BMP signaling , and can *regulate* [BMP] signaling through a positive feedback loop repressing Twist-1 function . Positive_regulation BMP3 KCP 15793581 1390289 Unlike chordin , *enhances* [BMP] signaling in a paracrine manner . Positive_regulation BMP3 MSX1 9846381 553862 BMPs may in some cases trigger the cell death cascade , while gene products *regulate* [Bmp] expression . Positive_regulation BMP3 OSR1 16243309 1483702 In explant cultures , Bmp activation of Odd skipped related 1 (Odd-1) , the earliest known gene expressed in the intermediate mesoderm , is blocked by cyclohexamide , indicating that the *activation* of by [Bmp] signaling is translation dependent . Positive_regulation BMP3 TNF 20067418 2193880 *upregulates* expression of BMP-2 and [BMP-3] genes in the rat dental follicle -- implications for tooth eruption . Positive_regulation BMP3 TNF 20067418 2193883 We found that [BMP-3] expression is correlated with the expression of TNF-alpha in the dental follicle and significantly *increased* BMP-2 and BMP-3 expression in vitro . Positive_regulation BMP3 TP63 19717565 2152064 Here we report a previously uncovered *role* of in controlling [bone morphogenetic protein (BMP)] signaling , which is required for maintaining low expression levels of several non-epidermal genes . Positive_regulation BMP4 CTGF 24112732 2852620 Importantly , Noggin treatment inhibited endogenous and BMP induced CCN2 expression , verifying that expression in developing tooth germs *requires* [BMP] signalling . Positive_regulation BMP4 EPHB2 22056560 2513919 We therefore focused on the relationship between Osterix and Erk1/2 during osteoblast differentiation because [BMP] signaling *induces* activation in osteoblasts . Positive_regulation BMP4 EPHB2 22072425 2585421 Based on this work , we conclude that extracellular matrix and [BMP] regulation of RUNX2 phosphorylation and transcriptional activity in osteoblasts is predominantly *mediated* by rather than p38 MAPKs . Positive_regulation BMP4 ID1 17374642 1720667 These findings suggest that Twist-1 can act as an inhibitor of BMP signaling , and can *regulate* [BMP] signaling through a positive feedback loop repressing Twist-1 function . Positive_regulation BMP4 ID1 20846028 2430886 In this study we demonstrate that human adipose derived stem cells ( ASCs ) express all components of the bone morphogenetic protein (BMP)/BMP receptor signaling pathway and respond to [BMP4] *inducing* upregulated expression of its specific target genes . Positive_regulation BMP4 IL1B 9213003 441533 alone had no effect on ALP activity , but it significantly *enhanced* [BMP-2- and -4-induced] ALP activity . Positive_regulation BMP4 KCP 15793581 1390290 Unlike chordin , *enhances* [BMP] signaling in a paracrine manner . Positive_regulation BMP4 MSX1 11023873 738394 In Msx1-deficient mice , tooth development arrests at the bud stage when is *required* for the expression of [Bmp4] and Fgf3 in the dental mesenchyme ( Bei , M. and Maas , R. ( 1998 ) Development 125 , 4325-4333 ) . Positive_regulation BMP4 MSX1 12163415 972372 We found that Msx1 expression was restricted to the anterior of the first upper molar site in the palatal mesenchyme and that was *required* for the expression of [Bmp4] and Bmp2 in the mesenchyme and Shh in the medial edge epithelium ( MEE ) in the same region of developing palate . Positive_regulation BMP4 MSX1 12944425 1135872 We also provide evidence that endogenous [Bmp4] expression is *regulated* by the combined activity of and Msx2 in the forming digit tip ; Positive_regulation BMP4 MSX1 21297014 2388339 This synergism of Msx1 with Pax9 is significant , because it is currently the only documented mechanism for *mediated* activation of [Bmp4] . Positive_regulation BMP4 MSX1 21465616 2417512 With this strategy , we demonstrate that mesenchymal expression of and Msx2 is *required* for proper Shh and [Bmp4] signaling to specify digit number and identity . Positive_regulation BMP4 MSX1 23720046 2796828 and Tbx2 antagonistically *regulate* [Bmp4] expression during the bud-to-cap stage transition in tooth development . Positive_regulation BMP4 MSX1 9846381 553864 BMPs may in some cases trigger the cell death cascade , while gene products *regulate* [Bmp] expression . Positive_regulation BMP4 NES 23562654 2782999 While high-content-analysis demonstrated that HDACi did not significantly induce caspase-3 or p21 activity , p53-expression was increased by VPA ( 3 mM , 5 mM ) at 48 h. HDACi-exposure *induced* mineralization per cell dose-dependently to a plateau level ( VPA-0.125 mM and TSA-25 nM ) with accompanying increases in mineralization/dentinogenic associated gene expression at 5 days ( DMP-1 , [BMP-2/-4] , ) and 10 days ( DSPP , BMP-2/-4 ) . Positive_regulation BMP4 OSR1 16243309 1483703 In explant cultures , [Bmp] *activation* of , the earliest known gene expressed in the intermediate mesoderm , is blocked by cyclohexamide , indicating that the activation of Odd-1 by Bmp signaling is translation dependent . Positive_regulation BMP4 TNF 10857772 704546 These results indicate that *stimulates* both cell proliferation and [BMP-4] expression but inhibits chondrogenesis in chondroprogenitor-like ATDC5 cells . Positive_regulation BMP4 TP63 19717565 2152065 Here we report a previously uncovered *role* of in controlling [bone morphogenetic protein (BMP)] signaling , which is required for maintaining low expression levels of several non-epidermal genes . Positive_regulation BMP5 CTGF 24112732 2852621 Importantly , Noggin treatment inhibited endogenous and BMP induced CCN2 expression , verifying that expression in developing tooth germs *requires* [BMP] signalling . Positive_regulation BMP5 EPHB2 22056560 2513920 We therefore focused on the relationship between Osterix and Erk1/2 during osteoblast differentiation because [BMP] signaling *induces* activation in osteoblasts . Positive_regulation BMP5 EPHB2 22072425 2585422 Based on this work , we conclude that extracellular matrix and [BMP] regulation of RUNX2 phosphorylation and transcriptional activity in osteoblasts is predominantly *mediated* by rather than p38 MAPKs . Positive_regulation BMP5 ID1 17374642 1720668 These findings suggest that Twist-1 can act as an inhibitor of BMP signaling , and can *regulate* [BMP] signaling through a positive feedback loop repressing Twist-1 function . Positive_regulation BMP5 KCP 15793581 1390291 Unlike chordin , *enhances* [BMP] signaling in a paracrine manner . Positive_regulation BMP5 MSX1 9846381 553866 BMPs may in some cases trigger the cell death cascade , while gene products *regulate* [Bmp] expression . Positive_regulation BMP5 OSR1 16243309 1483704 In explant cultures , Bmp activation of Odd skipped related 1 (Odd-1) , the earliest known gene expressed in the intermediate mesoderm , is blocked by cyclohexamide , indicating that the *activation* of by [Bmp] signaling is translation dependent . Positive_regulation BMP5 TNF 21319131 2469720 Stimulation of HK-2 cells with TGF-ß , and AT-II *resulted* in a significant decreased expression of [BMP-5] and its receptors . Positive_regulation BMP5 TP63 19717565 2152066 Here we report a previously uncovered *role* of in controlling [bone morphogenetic protein (BMP)] signaling , which is required for maintaining low expression levels of several non-epidermal genes . Positive_regulation BMP6 CTGF 24112732 2852622 Importantly , Noggin treatment inhibited endogenous and BMP induced CCN2 expression , verifying that expression in developing tooth germs *requires* [BMP] signalling . Positive_regulation BMP6 EPHB2 22056560 2513921 We therefore focused on the relationship between Osterix and Erk1/2 during osteoblast differentiation because [BMP] signaling *induces* activation in osteoblasts . Positive_regulation BMP6 EPHB2 22072425 2585423 Based on this work , we conclude that extracellular matrix and [BMP] regulation of RUNX2 phosphorylation and transcriptional activity in osteoblasts is predominantly *mediated* by rather than p38 MAPKs . Positive_regulation BMP6 ID1 17374642 1720669 These findings suggest that Twist-1 can act as an inhibitor of BMP signaling , and can *regulate* [BMP] signaling through a positive feedback loop repressing Twist-1 function . Positive_regulation BMP6 KCP 15793581 1390292 Unlike chordin , *enhances* [BMP] signaling in a paracrine manner . Positive_regulation BMP6 MSX1 9846381 553868 BMPs may in some cases trigger the cell death cascade , while gene products *regulate* [Bmp] expression . Positive_regulation BMP6 OSR1 16243309 1483705 In explant cultures , [Bmp] *activation* of , the earliest known gene expressed in the intermediate mesoderm , is blocked by cyclohexamide , indicating that the activation of Odd-1 by Bmp signaling is translation dependent . Positive_regulation BMP6 TNF 12823853 1104332 Among these genes we identified the following : *stimulated* gene-6 ( TSG-6 ) , IL-6 , IL-8 , GRO-beta , and [bone morphogenetic protein-6] with an expression 3.6-10.6-fold that in the unstimulated control . Positive_regulation BMP6 TNF 19191909 2127898 In addition , [BMP-6] *induced* expression of pro-inflammatory inducible nitric oxide synthase (iNOS) and the cytokine . Positive_regulation BMP6 TP63 19717565 2152067 Here we report a previously uncovered *role* of in controlling [bone morphogenetic protein (BMP)] signaling , which is required for maintaining low expression levels of several non-epidermal genes . Positive_regulation BMP7 CTGF 24112732 2852623 Importantly , Noggin treatment inhibited endogenous and BMP induced CCN2 expression , verifying that expression in developing tooth germs *requires* [BMP] signalling . Positive_regulation BMP7 EPHB2 20038543 2299501 *induced* [BMP7] expression in the developing cerebral cortex induces premature radial glia differentiation and impairs neuronal migration . Positive_regulation BMP7 EPHB2 22056560 2513922 We therefore focused on the relationship between Osterix and Erk1/2 during osteoblast differentiation because [BMP] signaling *induces* activation in osteoblasts . Positive_regulation BMP7 EPHB2 22072425 2585424 Based on this work , we conclude that extracellular matrix and [BMP] regulation of RUNX2 phosphorylation and transcriptional activity in osteoblasts is predominantly *mediated* by rather than p38 MAPKs . Positive_regulation BMP7 ID1 17374642 1720670 These findings suggest that Twist-1 can act as an inhibitor of BMP signaling , and can *regulate* [BMP] signaling through a positive feedback loop repressing Twist-1 function . Positive_regulation BMP7 IL1B 12233782 988751 *Induction* of [osteogenic protein-1] expression by in cultured rabbit articular chondrocytes . Positive_regulation BMP7 IL1B 12233782 988753 Our results demonstrate that [OP-1] expression is *induced* by and suggest that this expression , like that of HAS-2 , may play a role as a protective mechanism against inflammatory cytokines . Positive_regulation BMP7 IL1B 17161615 1663722 [BMP-7] *induced* mainly anabolic activation of chondrocytes including classical target genes such as collagen type II and aggrecan , while , both , significantly modulated the gene expression levels of numerous genes ; Positive_regulation BMP7 KCP 15793581 1390293 Unlike chordin , *enhances* [BMP] signaling in a paracrine manner . Positive_regulation BMP7 KCP 18508541 1918111 The activity of [BMP7] is reduced by inhibitors including some members of the dan-cerberus group and CTGF but can be *enhanced* by endoglin and . Positive_regulation BMP7 MMP7 22215634 2559035 BMP-7 signaling is essential for normal kidney development , and overexpression of catalytically active in human embryonic kidney 293 cells *reduces* endogenous [BMP-7] protein levels and inhibits phosphorylation of BMP-7 SMAD signaling intermediates . Positive_regulation BMP7 MSX1 9846381 553870 BMPs may in some cases trigger the cell death cascade , while gene products *regulate* [Bmp] expression . Positive_regulation BMP7 OSR1 16243309 1483706 In explant cultures , Bmp activation of Odd skipped related 1 (Odd-1) , the earliest known gene expressed in the intermediate mesoderm , is blocked by cyclohexamide , indicating that the *activation* of by [Bmp] signaling is translation dependent . Positive_regulation BMP7 TP63 19717565 2152068 Here we report a previously uncovered *role* of in controlling [bone morphogenetic protein (BMP)] signaling , which is required for maintaining low expression levels of several non-epidermal genes . Positive_regulation BMP7 TP63 19717565 2152080 represses transcription of the inhibitory Smad7 and *activates* [Bmp7] , thereby sustaining BMP signaling . Positive_regulation BMPR1A IL1B 19116903 2025022 *reduced* the number of activin receptor-like kinase 2 (ALK-2) and [ALK-3] receptors , inhibited expression of Smad1 and Smad6 , delayed and prematurely terminated the onset of OP-1 mediated R-Smad phosphorylation , and affected nuclear translocation of R-Smad/Smad4 complexes . Positive_regulation BMX F2R 20559570 2279996 activation *induces* [Etk/Bmx] and Shc binding to the receptor C-tail to form a complex . Positive_regulation BMX TNF 12370298 995740 Thus , TRAF2 is not involved in *induced* [Etk] activation , suggesting a novel mechanism for Etk activation by cytokine receptors . Positive_regulation BMX TNF 14532277 1174858 , via its receptor 2 ( TNFR2 ) , *induces* [Etk] ( or Bmx ) activation and Etk dependent endothelial cell ( EC ) migration and tube formation . Positive_regulation BMX TNF 14532277 1174859 Because TNF receptor 2 lacks an intrinsic kinase activity , we examined the kinase ( s ) mediating *induced* [Etk] activation . Positive_regulation BMX TNF 14532277 1174860 *induces* a coordinated phosphorylation of vascular endothelial growth factor ( VEGF ) receptor 2 ( VEGFR2 ) and [Etk] , which is blocked by VEGFR2-specific inhibitors . Positive_regulation BMX TNF 14532277 1174864 In *response* to , [Etk] and VEGFR2 form a complex resulting in a reciprocal activation between the two kinases . Positive_regulation BMX TNF 14532277 1174882 However , *induces* phosphorylation of [Etk] at Tyr-566 , directly mediating the recruitment of the p85 subunit of PI3K . Positive_regulation BMX TNF 14532277 1174897 Taken together , our data demonstrated that induces transactivation between Etk and VEGFR2 , and [Etk] directly *activates* PI3K-Akt angiogenic signaling independent of VEGF induced VEGFR2-PI3K-Akt signaling pathway . Positive_regulation BMX TNF 16195372 1462893 Wild-type *induces* TNFR2 and [Etk] and activates both ASK1 and Etk but does not down-regulate TNFR1 . Positive_regulation BMX TNF 19788501 2168441 In ( WT ) C57BL/6 myocardium , *activated* both ASK1 and [Etk] , and increased both apoptosis and cell cycle entry . Positive_regulation BNIP3 FOXO1 21325132 2393868 This autophagic response is caused by *induced* expression of [Bnip3] that displaces the autophagic effector Beclin-1 from inactive Bcl-XL complexes . Positive_regulation BNIP3 TNF 19321129 2052464 Role of BNIP3 in TNF induced cell death -- *upregulates* [BNIP3] expression . Positive_regulation BNIP3 TNF 22961439 2715958 also *caused* a significant increase in the expression of apoptotic proteins Bax , Caspase 3 and PARP cleavage , [Bnip3] , and TGF-ß , whereas OA modulated these changes . Positive_regulation BPI AKT1 18055828 1833391 The authors recently reported that [BPI] can *induce* ERK1/2 and activity and that it increases DNA synthesis in the bovine retinal pigment epithelial (RPE) and pericyte cells . Positive_regulation BPI AKT2 18055828 1833392 The authors recently reported that [BPI] can *induce* ERK1/2 and activity and that it increases DNA synthesis in the bovine retinal pigment epithelial (RPE) and pericyte cells . Positive_regulation BPI AKT3 18055828 1833393 The authors recently reported that [BPI] can *induce* ERK1/2 and activity and that it increases DNA synthesis in the bovine retinal pigment epithelial (RPE) and pericyte cells . Positive_regulation BPI C5 8985203 409076 In addition , the inflammatory mediator tumor necrosis factor (TNF)-alpha potently activated PMNL in whole blood , via TNF receptor p55 , to release BPI , whereas interleukin (IL)-1 , IL-8 , platelet activating factor , and were poor *inducers* of [BPI] release . Positive_regulation BPI CCNC 11891303 922732 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI CDK19 11891303 922737 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI CDK8 11891303 922735 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI CEBPE 17483073 1738820 In this study , we studied the *role* of a myeloid-specific transcription factor , ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Positive_regulation BPI IL1A 2174352 145670 stimulation of hepatocytes *leads* to nuclear translocation of the NF kappa B-like [BPi] which competes with the constitutive C/EBP-like BPcs for overlapping binding sites on the APRE and thereby replaces weak transcriptional activators with a stronger one . Positive_regulation BPI IL1A 8985203 409077 In addition , the inflammatory mediator tumor necrosis factor (TNF)-alpha potently activated PMNL in whole blood , via TNF receptor p55 , to release BPI , whereas , IL-8 , platelet activating factor , and C5a were poor *inducers* of [BPI] release . Positive_regulation BPI IL8 8985203 409078 In addition , the inflammatory mediator tumor necrosis factor (TNF)-alpha potently activated PMNL in whole blood , via TNF receptor p55 , to release BPI , whereas interleukin (IL)-1 , , platelet activating factor , and C5a were poor *inducers* of [BPI] release . Positive_regulation BPI LTA 8985203 409074 FMLP , serum treated zymosan (STZ) , and also *induced* [BPI] release . Positive_regulation BPI MAPK3 18055828 1833394 The authors recently reported that [BPI] can *induce* and Akt activity and that it increases DNA synthesis in the bovine retinal pigment epithelial (RPE) and pericyte cells . Positive_regulation BPI MED1 11891303 922759 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED10 11891303 922755 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED11 11891303 922758 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED12 11891303 922730 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED13 11891303 922740 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED13L 11891303 922741 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED14 11891303 922745 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED15 11891303 922731 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED16 11891303 922734 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED17 11891303 922747 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED18 11891303 922754 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED19 11891303 922757 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED20 11891303 922733 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED21 11891303 922728 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED22 11891303 922729 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED23 11891303 922746 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED24 11891303 922742 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED25 11891303 922756 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED26 11891303 922748 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED27 11891303 922749 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED28 11891303 922752 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED29 11891303 922744 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED30 11891303 922743 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED31 11891303 922751 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED4 11891303 922736 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED6 11891303 922738 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED7 11891303 922750 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED8 11891303 922739 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI MED9 11891303 922753 Lipid *induced* expression of bactericidal/ permeability increasing protein ( [BPI] ) in human mucosal epithelia . Positive_regulation BPI NPTX1 8040321 266668 [BPI] and p15A display similar features of antibacterial action distinct from defensin NP-1 , but *acts* synergistically only with BPI and not with p15A . Positive_regulation BPI SP1 16282362 1518464 Studies of BPI promoter expression in IECs identified regulatory regions of the BPI promoter and revealed a prominent *role* for CCAAT/enhancer binding protein and especially in the basal regulation of [BPI] . Positive_regulation BPI SP3 16282362 1518465 Studies of BPI promoter expression in IECs identified regulatory regions of the BPI promoter and revealed a prominent *role* for CCAAT/enhancer binding protein and especially in the basal regulation of [BPI] . Positive_regulation BPI ST3GAL4 8985203 409073 FMLP , , and lipoteichoic acid (LTA) also *induced* [BPI] release . Positive_regulation BPI TCF12 17483073 1738812 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Positive_regulation BPI TCF15 17483073 1738813 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Positive_regulation BPI TCF19 17483073 1738814 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Positive_regulation BPI TCF20 17483073 1738815 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Positive_regulation BPI TCF21 17483073 1738816 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Positive_regulation BPI TCF23 17483073 1738821 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Positive_regulation BPI TCF24 17483073 1738823 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Positive_regulation BPI TCF25 17483073 1738822 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Positive_regulation BPI TCF3 17483073 1738817 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Positive_regulation BPI TCF4 17483073 1738818 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Positive_regulation BPI TCF7 17483073 1738819 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Positive_regulation BPI TNF 8648149 363679 To assess the *role* of in the elevated [BPI] levels during sepsis , the following studies were performed . Positive_regulation BPI TNF 8648149 363681 These results suggest that is not *critical* for the release of [BPI] from neutrophils during experimental endotoxemia or clinical sepsis . Positive_regulation BPI TP53 18451163 1902887 [BPI] could thus *induce* a response even in the presence of mutant p53 . Positive_regulation BPNT1 EPHB2 15731359 1402988 We report that : 1 ) insulin induced transcription of ATF-3 , [Pip92] , and Insig-1 *required* activation ; Positive_regulation BPNT1 MAP2K6 15731359 1402995 We report that : 1 ) insulin induced transcription of ATF-3 , [Pip92] , and Insig-1 *required* activation ; Positive_regulation BPNT1 MAP2K6 19121089 2019415 A ( MEK ) inhibitor *reduced* the accumulation of [PIP] at membranes and development of pseudopodia , and restored stable cortical actin , reducing the motility . Positive_regulation BPNT1 SRGN 2822001 78670 Ca2+ increased basal and p [ NH ] *stimulated* breakdown of [PIP2] . Positive_regulation BRAF ABCG2 23153455 2729645 Moreover , we revealed that in the *presence* of functional , [BRAF] kinase inhibition by vemurafenib is reduced in BRAF ( V600E ) mutant A375 cells . Positive_regulation BRAF EPHB2 11296228 801464 activation is normal in Raf-1-deficient cells and embryos , and is probably *mediated* by [B-RAF] . Positive_regulation BRAF EPHB2 12364324 1019124 GLP1 stimulated activation of is blocked by inhibitors of MEK , but GLP1 does not *induce* the activation of A-Raf , [B-Raf] , C-Raf , or Ras . Positive_regulation BRAF EPHB2 15263001 1296083 In M-1 cells , we showed that calcium restriction was associated with an elevation in [B-Raf] protein levels and cAMP stimulated , Ras dependent *activation* of B-Raf and . Positive_regulation BRAF EPHB2 16508002 1529835 However , *induced* phosphorylation of [B-Raf] on T753 promoted the disassembly of Raf heterodimers , and the mutation of T753 prolonged growth factor induced heterodimerization . Positive_regulation BRAF EPHB2 18335053 1881509 We found that the pathway structure is characterized by *mediated* positive feedback regulation of [B-Raf] and B-Raf mediated negative regulation of Raf-1 . Positive_regulation BRAF EPHB2 18508762 1939431 The majority of melanoma associated B-Raf mutations involve a single point mutation , V600E , which results in greatly elevated [B-Raf] kinase activity and constitutive *activation* of downstream . Positive_regulation BRAF EPHB2 22506009 2583953 However , ( T599A ) [B-RAF] did not destabilize the inactive conformation of the B-RAF kinase , and did not *induce* increased phosphorylation or C-RAF transactivation . Positive_regulation BRAF EPHB2 22871572 2671680 KRAS ( G12D ) - and [BRAF] ( V600E ) -induced transformation of murine pancreatic epithelial cells *requires* stimulated IGF1R signaling . Positive_regulation BRAF EPHB2 22892241 2666318 However , unlike ( V600E ) Braf , Mek/Erk pathway activation was mediated by both Craf and [Braf] , and ATP-competitive RAF inhibitors *induced* paradoxical pathway activation . Positive_regulation BRAF IL1B 20509944 2294875 Dynamic strain did not induce B-Raf activation but instead inhibited *induced* [B-Raf] activation . Positive_regulation BRAF MAP2K6 11296228 801470 activation is normal in Raf-1-deficient cells and embryos , and is probably *mediated* by [B-RAF] . Positive_regulation BRAF MAP2K6 22871572 2671687 KRAS ( G12D ) - and [BRAF] ( V600E ) -induced transformation of murine pancreatic epithelial cells *requires* stimulated IGF1R signaling . Positive_regulation BRAF MAP2K6 22892241 2666324 However , unlike ( V600E ) Braf , Mek/Erk pathway activation was mediated by both Craf and [Braf] , and ATP-competitive RAF inhibitors *induced* paradoxical pathway activation . Positive_regulation BRAF MAP2K6 23020132 2694450 To address this problem , we conducted a phase 1 and 2 trial of combined treatment with dabrafenib , a selective [BRAF] *inhibitor* , and trametinib , a selective MAPK kinase ( ) inhibitor . Positive_regulation BRAF MAP2K6 25037257 2948642 Dermatologic adverse events to chemotherapeutic agents , Part 2 : [BRAF] *inhibitors* , inhibitors , and ipilimumab . Positive_regulation BRAF MAP2K6 25155755 2957448 Taken together , these findings reveal a regulatory role for [BRAF] in the MAPK pathway independent of its kinase activity but *dependent* on interaction with . Positive_regulation BRAF PDE5A 24710960 2938894 Recent studies have shown that [BRAF] activation down-regulates PDE5A levels , and low expression by BRAF activation or sildenafil use *increases* the invasiveness of melanoma cells , which raises the possible adverse effect of sildenafil use on melanoma risk . Positive_regulation BRAF PLAU 22702340 2681742 In PTC , [BRAF] ( V600E ) *induces* and uPAR expression . Positive_regulation BRAP NT5E 17693717 1782073 One of the genes , aphA , encoded a <5'-nucleotidase> activity and was *induced* by [IMP] or inosine . Positive_regulation BRCA1 CCND1 10660629 664715 Moreover , ectopic expression of and Cdk4 can *stimulate* the [Brca1] promoter in an E2F dependent manner , and this is inhibited by coexpression of the p16(INK4a) cyclin dependent kinase inhibitor . Positive_regulation BRCA1 CCND1 17334399 1772004 Using chromatin immunoprecipitation assays , we observed that the inhibition of activity *resulted* in increased [BRCA1] DNA binding at particular promoters in vivo . Positive_regulation BRCA1 CCND1 17334399 1772006 Collectively , these results indicate that *mediated* phosphorylation of [BRCA1] inhibits the ability of BRCA1 to be recruited to particular promoters in vivo . Positive_regulation BRCA1 SLCO2A1 21212407 2386318 Overexpressing reduced extracellular PGE ( 2 ) levels , suppressed the cAMP ? PKA pathway , *enhanced* the interaction between [BRCA1] and p300 , and inhibited aromatase expression . Positive_regulation BRCA2 EPHB2 17143532 1668085 Disruption of with PD98059 *prevented* any [BRCA2] upregulation inhibiting DNA synthesis below basal levels . Positive_regulation BRF1 EPHB2 16541106 1541959 *mediates* this induction of [Brf1] expression and therefore contributes in at least two ways to pol III transcriptional activation during hypertrophy . Positive_regulation BSG EPHB2 20107538 2178629 Stimulation of [CD147] with its specific monoclonal antibody induced the expression of matrix metalloproteinase (MMP)-9 in THP-1 cells and it was *suppressed* by inhibitors of both and NF-kappaB . Positive_regulation BSG IL1B 16522689 1567942 *stimulated* MMP-1 ( 5.6-fold ) , MMP-2 ( 2.8-fold ) , and MMP-3 ( 75-fold ) gene expression , but not [EMMPRIN] , over levels in control cells ( P < 0.05 ) . Positive_regulation BSG LAMB3 18243135 1871447 In contrast , type IV collagen and did not *induce* [EMMPRIN] . Positive_regulation BSG MMP28 14985463 1214905 Increased activity in tumor local environment *results* in proteolytic cleavage of membrane associated [EMMPRIN] , releasing soluble EMMPRIN . Positive_regulation BSG MMP28 15201341 1288939 It was shown previously that caveolin-1 associates with CD147 , thus inhibiting [CD147] self-aggregation and *induction* ; Positive_regulation BSG MMP28 15781323 1385548 Later studies have shown that [EMMPRIN] can also *induce* in the same population of cells . Positive_regulation BSG MMP28 16733664 1624852 Experimental in vitro data has showed that *inducing* activity of [CD147] is under the control of caveolin-1 . Positive_regulation BSG MMP28 19003972 2016289 In summary the data argue against a causal *role* for [EMMPRIN] for the induction of gene expression during adult mammary gland development . Positive_regulation BSG MMP28 19056510 2035429 Our studies which aimed to explore mechanisms of matrix degradation in pathological corneal wound healing have shown that [EMMPRIN] , a glycoprotein expressed on corneal epithelial cell surface , can *induce* production and myofibroblasts differentiation after direct interaction with corneal fibroblasts . Positive_regulation BSG MMP7 14985463 1214920 Increased activity in tumor local environment *results* in proteolytic cleavage of membrane associated [EMMPRIN] , releasing soluble EMMPRIN . Positive_regulation BSG MMP7 15201341 1288954 It was shown previously that caveolin-1 associates with CD147 , thus inhibiting [CD147] self-aggregation and *induction* ; Positive_regulation BSG MMP7 15781323 1385563 Later studies have shown that [EMMPRIN] can also *induce* in the same population of cells . Positive_regulation BSG MMP7 16733664 1624867 Experimental in vitro data has showed that *inducing* activity of [CD147] is under the control of caveolin-1 . Positive_regulation BSG MMP7 19003972 2016304 In summary the data argue against a causal *role* for [EMMPRIN] for the induction of gene expression during adult mammary gland development . Positive_regulation BSG MMP7 19056510 2035444 Our studies which aimed to explore mechanisms of matrix degradation in pathological corneal wound healing have shown that [EMMPRIN] , a glycoprotein expressed on corneal epithelial cell surface , can *induce* production and myofibroblasts differentiation after direct interaction with corneal fibroblasts . Positive_regulation BST1 TNF 16705149 1589858 but not RANK-L *led* to the sustained upregulation of both CD38 and [CD157] as demonstrated by real-time PCR and flow cytometry . Positive_regulation BST2 TNF 23401591 2748649 IFN-? , IL-4 , IL-10 , and *had* only marginal effects on [BST2] expression in blood leukocytes compared with TLR9L . Positive_regulation BTRC EPHB2 11412047 828327 [SCF] *induced* a rapid and transient activation of and p38 in a dose dependent manner . Positive_regulation BTRC EPHB2 16436136 1516424 The induction of RANTES by SCF or TNF-alpha was mediated by and NF-kappaB , respectively , and [SCF] induced MIP-1beta release was *mediated* by ERK . Positive_regulation BTRC FAS 17695539 1782183 High expression of [c-kit/SCF] ( 2+ , 3+ ) was *detected* in 28/45 cases of EFT ( 62.2 % ) , whereas and IGF-IR were observed in 16/45 ( 37.7 % ) and 9/45 ( 20 % ) , respectively . Positive_regulation BTRC IL1B 11934803 927863 5. Budesonide inhibited *induced* [SCF] mRNA expression ( -68 % ) at 2 .5 h and even more so at 10 h ( -192 % ) Positive_regulation BTRC IL1B 15735017 1378393 In PancTu-1 cells , betaTRCP1 expression is inhibited , at least in part , by the interleukin-1 (IL-1) receptor ( I ) antagonist , whereas stimulation of PT45-P1 cells with *resulted* in an increased expression of [betaTRCP1] , and transfection of this cell line with betaTRCP1 induced IL-1beta secretion in a NF-kappaB dependent fashion . Positive_regulation BTRC IL1B 15962114 1423089 Transfection experiments with the SCF promoter including intron1 also confirm this increase and decrease of SCF expression by IL-1beta and glucocorticoids , and the potentiation by glucocorticoids of the *induced* [SCF] expression . Positive_regulation BTRC IL1B 16407046 1513295 We investigated whether HDSMCs are capable of expressing and releasing MCP-1 , IL-6 and [SCF] in *response* to IL-4 , IL-13 , and tumor necrosis factor-alpha . Positive_regulation BTRC IL1B 16612597 1665858 The effect of exogenous IFNgamma on AML blast proliferation was dependent on the local cytokine network and IFNgamma ( 1 ) inhibited proliferation in the *presence* of exogenous , GM-CSF , G-CSF and [SCF] ; Positive_regulation BTRC IL1B 7544739 318385 Stimulation with only modestly *increased* SCF mRNA levels , soluble SCF production at 24 hours , and membrane bound [SCF] . Positive_regulation BTRC JAG1 10342559 616491 However , in the presence of [SCF] alone , *increased* erythroid colony formation twofold . Positive_regulation BTRC TNF 10067879 594036 Activin , TGF beta , TGF alpha , and *had* no effect on [SCF] gene expression in vitro . Positive_regulation BTRC TNF 16407046 1513294 We investigated whether HDSMCs are capable of expressing and releasing MCP-1 , IL-6 and [SCF] in *response* to IL-4 , IL-13 , IL-1beta and . Positive_regulation BTRC TNF 16436136 1516378 Either [SCF] or TNF-alpha could *induce* release from HMC-1 cells of interleukin (IL)-8 , monocyte chemoattractant protein (MCP)-1 , regulated upon activation normal T-cell expressed and secreted ( RANTES ) , and I-309 , while SCF and induced release of macrophage inflammatory protein (MIP)-1beta and interferon-gamma-inducible protein-10 (IP-10) , respectively . Positive_regulation BTRC TNF 18549896 1923753 In vitro studies using primary mouse hepatocytes show that [SCF] is *induced* by ; Positive_regulation BTRC TNF 7544739 318388 Similarly , a sustained increase in soluble SCF production was detected during 1 to 5 days of hydrocortisone exposure ( 0.27 +/- 0.03 to 1.10 +/- 0.08 ng/mL per 10 ( 6 ) cells ) , while stimulation modestly *increased* the production of soluble [SCF] in 24-hour cultures only . Positive_regulation BTRC TNF 9307079 454438 We have shown that the [SCF] expression can be induced in vitro by co-culture with mast cells and this induction was *dependent* on the release of . Positive_regulation BTRC TNF 9637535 513871 [SCF] was constitutively produced from fibroblasts in its transmembrane form and could be *induced* by . Positive_regulation BTRC TNF 9759885 536632 Coligation of SCFR augmented Fc epsilonRI mediated activation of MAP kinases , especially JNK activation , and SCF augmented Fc epsilonRI mediated TNF-alpha production in MC/9 cells , although [SCF] alone did not *induce* production . Positive_regulation BUB1 STK39 18083840 1836942 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation BUD31 TNF 8766549 374986 In contrast , neither mAb [10G10] , which recognizes an epitope distinct from the one recognized by mAb 4B2 , nor mAb UCHL-1 , a CD45RO-specific antibody , *induced* any significant increase in transcription . Positive_regulation C10orf10 FOXO1 21510935 2439344 *regulates* expression of [decidual protein induced by progesterone] ( DEPP ) in human endothelial cells . Positive_regulation C12orf57 CA12 12606647 1079760 [C10] *induced* a rapid , sustained increase in . Positive_regulation C12orf57 TNF 11035713 741081 In vitro studies showed that the combination of IL-1beta and C10 markedly augmented synthesis by peritoneal macrophages and that [C10] synthesis was *induced* in these cells following their exposure to IL-13 . Positive_regulation C12orf75 INHBA 15671249 1366137 *increased* the proliferation of four of eight ovarian cancer cell lines ( SKOV3 , [OCC1] , OVCAR3 , and A2780-s ) . Positive_regulation C12orf75 LPA 11330965 808306 We describe here that , S1P , and SPC *increased* mRNA levels ( 2- to 7-fold ) and protein secretion ( 2- to 12-fold ) of IL-8 from ovarian cancer cells ( HEY , [OCC1] , and SKOV3 ) in vitro . Positive_regulation C12orf75 MBTPS1 11330965 808305 We describe here that LPA , , and SPC *increased* mRNA levels ( 2- to 7-fold ) and protein secretion ( 2- to 12-fold ) of IL-8 from ovarian cancer cells ( HEY , [OCC1] , and SKOV3 ) in vitro . Positive_regulation C12orf75 SFTPC 11330965 808304 We describe here that LPA , S1P , and *increased* mRNA levels ( 2- to 7-fold ) and protein secretion ( 2- to 12-fold ) of IL-8 from ovarian cancer cells ( HEY , [OCC1] , and SKOV3 ) in vitro . Positive_regulation C19orf10 JAG1 20855881 2331641 The outgrowth of the Th2 responses was dependent on airway epithelial cell derived [IL-25] , which *induced* the upregulation of the notch ligand on dendritic cells . Positive_regulation C1orf228 TLR7 22685319 2676002 Interestingly , despite expression of TLR mRNA on Kupffer cells , ligation of TLR4 , , and TLR9 *resulted* in a weak induction of IL-10 , low or undetectable levels of [IL-12p40] and TNF , and up-regulation of CD40 on the surface . Positive_regulation C1orf228 TNF 15963988 1428207 enhances phenotypic and functional maturation of human epidermal Langerhans cells and *induces* IL-12 [p40] and IP-10/CXCL-10 production . Positive_regulation C1orf228 TNF 18760623 1975404 *stimulated* secretion of [IL-12p40] was significantly increased by 30 min ; Positive_regulation C1QA C1QTNF1 18171693 1894950 [Complement-C1q TNF related protein 1 (CTRP1)] , a member of the CTRP superfamily , is expressed at high levels in adipose tissues of obese Zucker diabetic fatty ( fa/fa ) rats , and expression is *induced* by proinflammatory cytokines , including TNF-alpha and IL-1beta . Positive_regulation C1QA TNF 10898508 712102 Studying the functional consequences of the interaction , we found that the release of from Mphi is *induced* by [C1q] but not by MBL . Positive_regulation C1QA TNF 17383729 1735479 Immobilized [C1q] *induced* maturation of MDCs and enhanced secretion of IL-12 and , moreover , elevated their T-cell stimulating capacity . Positive_regulation C1QA TNF 8603439 352191 Transfection of L929 with murine C1q B-chain antisense plasmid cDNA rendered them markedly less susceptible to *mediated* cytotoxicity coincident with a decreased capacity for TNF-alpha binding and expression of cell surface [C1q] protein . Positive_regulation C1QA TNF 9407058 470672 The capacity to bind [C1q] , mediated by the pentraxin domain , is consistent with the view that PTX3 , produced in tissues by endothelial cells or macrophages in *response* to interleukin-1 and , may act as a local regulator of innate immunity . Positive_regulation C1QB C1QTNF1 18171693 1894951 [Complement-C1q TNF related protein 1 (CTRP1)] , a member of the CTRP superfamily , is expressed at high levels in adipose tissues of obese Zucker diabetic fatty ( fa/fa ) rats , and expression is *induced* by proinflammatory cytokines , including TNF-alpha and IL-1beta . Positive_regulation C1QB TNF 10898508 712103 Studying the functional consequences of the interaction , we found that the release of from Mphi is *induced* by [C1q] but not by MBL . Positive_regulation C1QB TNF 17383729 1735482 Immobilized [C1q] *induced* maturation of MDCs and enhanced secretion of IL-12 and , moreover , elevated their T-cell stimulating capacity . Positive_regulation C1QB TNF 8603439 352192 Transfection of L929 with murine C1q B-chain antisense plasmid cDNA rendered them markedly less susceptible to *mediated* cytotoxicity coincident with a decreased capacity for TNF-alpha binding and expression of cell surface [C1q] protein . Positive_regulation C1QB TNF 9407058 470700 The capacity to bind [C1q] , mediated by the pentraxin domain , is consistent with the view that PTX3 , produced in tissues by endothelial cells or macrophages in *response* to interleukin-1 and , may act as a local regulator of innate immunity . Positive_regulation C1QBP TNF 10360628 619674 The results demonstrate that the expression of both cC1qR and [gC1qR] by bone marrow vascular endothelial cells is *up-regulated* by inflammatory mediators , interferon-gamma , , and lipopolysaccharide ( Escherichia coli , 055 : B5 ) in a dose- and time dependent manner , as detected by enzyme linked immunosorbent assay . Positive_regulation C1QTNF1 C1QA 18171693 1894952 , a member of the CTRP superfamily , is expressed at high levels in adipose tissues of obese Zucker diabetic fatty ( fa/fa ) rats , and [CTRP1] expression is *induced* by proinflammatory cytokines , including TNF-alpha and IL-1beta . Positive_regulation C1QTNF1 C1QB 18171693 1894953 , a member of the CTRP superfamily , is expressed at high levels in adipose tissues of obese Zucker diabetic fatty ( fa/fa ) rats , and [CTRP1] expression is *induced* by proinflammatory cytokines , including TNF-alpha and IL-1beta . Positive_regulation C1QTNF1 IL1B 16806199 1580421 Tumor necrosis factor-alpha and *increases* [CTRP1] expression in adipose tissue . Positive_regulation C1R IL1B 12746311 1088760 In conclusion , both [C1r] and C1s are released by cultured fibroblasts , and the release of each into fibroblast or porcine smooth muscle cells medium is *stimulated* by TNFalpha and . Positive_regulation C1R TNF 12746311 1088759 In conclusion , both [C1r] and C1s are released by cultured fibroblasts , and the release of each into fibroblast or porcine smooth muscle cells medium is *stimulated* by and IL-1beta . Positive_regulation C1S IL1B 12356684 994000 In contrast , [C1s] promoter activity was strongly *up-regulated* by IL-6 , and IFN-gamma . Positive_regulation C1S IL1B 12746311 1088762 In conclusion , both C1r and [C1s] are released by cultured fibroblasts , and the release of each into fibroblast or porcine smooth muscle cells medium is *stimulated* by TNFalpha and . Positive_regulation C1S TNF 12746311 1088761 In conclusion , both C1r and [C1s] are released by cultured fibroblasts , and the release of each into fibroblast or porcine smooth muscle cells medium is *stimulated* by and IL-1beta . Positive_regulation C3 CFI 15102797 1239925 Cleavage of [complement C3b] to iC3b on the surface of Staphylococcus aureus is *mediated* by serum . Positive_regulation C3 CFI 301546 5715 However , in the *presence* of highly purified beta1H and , both C3bIna , both [C3b] and C4b were cleaved . Positive_regulation C3 CFI 9796985 543502 Like serum FH , the urine antigen was demonstrated to have a complement factor C3b binding site and to accelerate the degradation of [C3b] in the *presence* of . Positive_regulation C3 EPHB2 15153516 1250122 In contrast , [C3a] *induced* a transient Ca ( 2+ ) mobilization and phosphorylation but failed to stimulate TrkA phosphorylation , NFAT activation , or MIP-1beta production . Positive_regulation C3 IFI27 11402501 824886 Furthermore , fH and factor *mediated* cleavage of agarose bound [C3b] into iC3b was decreased in the presence of pepAred . Positive_regulation C3 IFI27 12645526 1069672 Soluble and cell associated KCP acted as a cofactor for factor *mediated* cleavage of both C4b and [C3b] and induced the cleavage products C4d and iC3b , respectively . Positive_regulation C3 IFI27 17764451 1848817 We previously reported that the KSHV complement control protein (KCP) was expressed on infected cells and virions , and could inhibit complement through decay accelerating activity ( DAA ) of the classical C3 convertase and cofactor activity (CFA) for factor *mediated* degradation of C4b and [C3b] , as well as acting as an attachment factor for binding to heparan sulphate on permissive cells . Positive_regulation C3 IFI27 22675461 2611407 Furthermore , rSdrE bound fH exhibited cofactor functionality for factor *mediated* cleavage of [C3b] to iC3b which correlated positively with increasing amounts of fH . Positive_regulation C3 IL1B 8617973 353948 Neither [C3a] nor C3a desArg alone *induced* detectable protein or mRNA levels for TNF-alpha and . Positive_regulation C3 IL1B 8887027 391386 The present findings indicate that intestinal epithelial cells are indeed capable of synthesizing [complement C3] in *response* to and TGF-beta . Positive_regulation C3 IL1B 9403532 469601 [Complement C3] production in human intestinal epithelial cells is *regulated* by and tumor necrosis factor alpha . Positive_regulation C3 ITGB2 9916743 587535 [C3a] *induced* selective shedding of L-selectin and an increase in alphaMbeta2 integrin expression on eosinophils but not neutrophils , while C5a induced shedding of L-selectin and up-regulation of on both eosinophils and neutrophils . Positive_regulation C3 TNF 10082594 599098 This study supports the hypothesis that [complement C3] is important in PV acantholysis and that complement activation is *increased* by IL-1alpha and . Positive_regulation C3 TNF 10540155 563247 Counter-regulatory effect of sodium butyrate on *induced* [complement C3] and factor B biosynthesis in human intestinal epithelial cells . Positive_regulation C3 TNF 10540155 563248 In this study , we tested the effects of butyrate on *induced* [complement C3] and factor B biosynthesis in human intestinal epithelial cells . Positive_regulation C3 TNF 10851266 701593 Sodium butyrate enhances *induced* [complement C3] secretion but suppresses TNF-alpha induced factor B secretion in intestinal epithelial cells . Positive_regulation C3 TNF 1716488 149593 The cytokines , granulocyte-macrophage colony stimulating factor ( GM-CSF ) , granulocyte colony stimulating factor ( G-CSF ) , and interleukin 1 (IL 1) all *caused* an upregulation of [C3b] receptors ( CR1 ) on neutrophils that ranged from around 76 % ( G-CSF and IL 1 ) to 93 % ( TNF alpha and GM-CSF ) of the upregulation obtained by pretreatment of the neutrophils with the chemotactic peptide FMLP . Positive_regulation C3 TNF 18195163 1863346 *induced* [complement C3] and interleukin-6 expression in VSMCs . Positive_regulation C3 TNF 8598489 350736 One hour after the start of the 30-min IL-1 infusion , which caused mild cardiovascular toxicity , plasma levels of IL-6 reached a peak of 25 +/- 9 ng/L ( mean +/- SEM ) , IL-8 reached a peak of 311 +/- 100 ng/L at 2 h , and nitrite/nitrate peaked after 10 h to 89 +/- 27 mumol/L . IL-1 did not *induce* significant changes in plasma levels of or of the complement activation products [C3a] and C4b/c . Positive_regulation C3 TNF 8617973 353947 Neither [C3a] nor C3a desArg alone *induced* detectable protein or mRNA levels for and IL-1 beta . Positive_regulation C3 TNF 9177453 434166 *stimulates* the biosynthesis of [complement C3] and factor B by human umbilical cord vein endothelial cells . Positive_regulation C3AR1 TNF 17498719 1848314 Myofibroblasts in stenotic , but not in control valves , expressed C3aR , and , in isolated myofibroblasts , and cigarette smoke *induced* [C3aR] mRNA expression ( p < 0.05 for both ) . Positive_regulation C4A IL1B 7704454 297583 significantly *enhanced* [C4S] production and significantly suppressed C6S production . Positive_regulation C4B CFI 301546 5716 However , in the *presence* of highly purified beta1H and , both C3bIna , both C3b and [C4b] were cleaved . Positive_regulation C4B IFI27 12645526 1069678 Soluble and cell associated KCP acted as a cofactor for factor *mediated* cleavage of both [C4b] and C3b and induced the cleavage products C4d and iC3b , respectively . Positive_regulation C4B IFI27 17764451 1848823 We previously reported that the KSHV complement control protein (KCP) was expressed on infected cells and virions , and could inhibit complement through decay accelerating activity ( DAA ) of the classical C3 convertase and cofactor activity (CFA) for factor *mediated* degradation of [C4b] and C3b , as well as acting as an attachment factor for binding to heparan sulphate on permissive cells . Positive_regulation C4B TNF 8598489 350737 One hour after the start of the 30-min IL-1 infusion , which caused mild cardiovascular toxicity , plasma levels of IL-6 reached a peak of 25 +/- 9 ng/L ( mean +/- SEM ) , IL-8 reached a peak of 311 +/- 100 ng/L at 2 h , and nitrite/nitrate peaked after 10 h to 89 +/- 27 mumol/L . IL-1 did not *induce* significant changes in plasma levels of or of the complement activation products C3a and [C4b/c] . Positive_regulation C4BPA TNF 1339286 206136 In contrast the synthetic glucocorticoid dexamethasone inhibited *induced* [C4BP] gene expression . Positive_regulation C4BPA TNF 1339286 206137 Rapid *induction* of [C4BP] mRNA levels by and IL-6 ( within 1 h ) and the observation that stimulation was inhibited by actinomycin D provided evidence that regulation of C4BP gene expression during the acute-phase response is regulated at the transcriptional level . Positive_regulation C5 CLU 12865662 1111902 Complement factor C3a release was suppressed by CAT , whereas *blocked* the complement cascade at the level of [C5b-9] formation . Positive_regulation C5 FHL1 15342420 1291966 Blocking factor activity also *enhanced* the release of anaphylatoxin [C5a] and moderately increased the susceptibility of these cells to complement mediated cytotoxicity . Positive_regulation C5 IL1B 12562384 1053786 In this study , we used a primary human RPE cell line ( RPE43 ) and found that [C5a] *induces* increased expression of , IL-6 , MCP-1 and GM-CSF mRNAs as well as IL-8 mRNA . Positive_regulation C5 IL1B 1769685 174858 The transcription of , however , can be *induced* by [C5a] alone . Positive_regulation C5 ITGB2 11801679 902594 In conclusion , alpha(5)beta(1) integrin may provide a contact dependent costimulus for eosinophil priming that , together with TNF-alpha , potentiated [C5a] *activation* of and increased eosinophil adhesion to ICAM-1 . Positive_regulation C5 ITGB2 9916743 587537 C3a induced selective shedding of L-selectin and an increase in alphaMbeta2 integrin expression on eosinophils but not neutrophils , while [C5a] *induced* shedding of L-selectin and up-regulation of on both eosinophils and neutrophils . Positive_regulation C5 TNF 10996218 733813 Intracerebral [complement C5a] receptor ( CD88 ) expression is *regulated* by and lymphotoxin-alpha following closed head injury in mice . Positive_regulation C5AR1 TNF 10996218 733817 These data show that the posttraumatic neuronal expression of the [C5aR] is , at least in part , *regulated* by and lymphotoxin-alpha at 7 days after trauma . Positive_regulation C9orf3 TNF 12614218 1065088 [Apo-Tf] or holo-Tf uniformly *induced* secretion in the cell supernatants from both groups . Positive_regulation C9orf3 TNF 7635986 317374 In summary , *stimulates* [apo] E gene transcription , mRNA abundance , and protein synthesis in the monocyte/macrophage in a phenotype-specific manner . Positive_regulation C9orf3 TNF 8083372 271117 Hepatic [apo] J mRNA levels *increased* 3.5- and 4.6-fold , with and IL-1 , respectively , and 8.2-fold with a combination of TNF and IL-1 . Positive_regulation CA1 EDN2 2499331 111903 Both in the presence and absence of extracellular Ca , *induced* rapid and dose dependent increases in [ [Ca]i] and in contraction . Positive_regulation CA1 EDN2 2686633 122623 ( 10 ( -10 ) -10 ( -6 ) M ) *induced* a dose dependent reversible membrane voltage depolarization and a dose dependent rise in [ [Ca]i] . Positive_regulation CA1 EPHB2 16741283 1566620 We found that activation of in vitro significantly *increased* histone H3 phosphorylation in hippocampal area [CA1] . Positive_regulation CA1 EPHB2 17822775 1882350 Both the increase of spines in [CA1] and the decrease of thorns in CA3 were completely *suppressed* by MAP kinase inhibitor . Positive_regulation CA1 ITGB2 10551644 565255 Antibody mediated inhibition of proliferation failed to impair the ability of T cells to subsequently proliferate in response to stimulation by the original or third party alloantigen or mobilize [ [Ca++]i] in *response* to CD3 or receptor ligation . Positive_regulation CA1 RGS2 18398336 1893704 Silencing in BS/GS patients *increased* Ang II-induced [Cai2+] release and ERK 1/2 phosphorylation in silenced cells compared with not silenced cells [ 59.3 +/- 10.8 ( peak-basal ) vs. 40.5 +/- 14.1 nmol/l , P = 0.017 and 0.84 +/- 0.06 vs. 0.64 +/- 0.08 nmol/l , P < 0.03 , respectively ] , whereas they were not different compared with controls ( 60.1 +/- 4.3 and 0.91 +/- 0.03 nmol/l ) . Positive_regulation CA1 TNF 2504305 115257 did not *increase* [Cai++] and , moreover , was able to stimulate accumulation of GM-CSF mRNA in the absence of extracellular Ca++ . Positive_regulation CA12 ATP5O 7796469 313718 These results suggest that the lidocaine induced shape change in human erythrocytes may occur by the conformational change of spectrin in a process that may be mediated by [carbonic anhydrase] and *activation* of . Positive_regulation CA12 C12orf57 12606647 1079759 *induced* a rapid , sustained increase in [Ca(i)2+] . Positive_regulation CA12 FLOT2 16788042 1577581 [Carbonic anhydrase (CA)] activity and relative expression of CA mRNA were measured in the gills of the euryhaline green crab Carcinus maenas in *response* to , injection of eyestalk extract and exposure to low salinity . Positive_regulation CA12 GAST 173424 2792 The results obtained suggest that the *activation* of [carbonic anhydrase] in vivo by ( pentagastrin ) , histamine and 3',5'-AMP is due to the phosphorylation of highly active isoenzyme by 3',5-AMP dependent protein kinase . Positive_regulation CA12 GAST 6116596 16875 *stimulated* oxyntic cell [carbonic anhydrase] in the dose range of 2.3 X 10 ( -15 ) to 2.3 X 10 ( -11 ) M . Positive_regulation CA12 GNRH2 15862567 1400963 Using Ca(i)2+ imaging and the calcium-sensitive dye fura-2 , we found that chicken ( cGnRH-II ) *induced* a rapid dose dependent increase in [Ca(i)2+] in dispersed tilapia lactotrophs . Positive_regulation CA12 GREM1 8581971 341181 Together , these findings suggest : ( *increases* [Ca(i)2+] in skate hepatocytes ; Positive_regulation CA12 IAPP 7926626 273621 Rat that has a 43 % homology with hCGRP *had* no effect on [carbonic anhydrase] activity . Positive_regulation CA12 MT-CO2 10423704 632617 The stimulatory effect of is *mediated* by [carbonic anhydrase] activity . Positive_regulation CA12 MT-CO2 16169965 1467525 Regulation of the expression of intracellular [beta-carbonic anhydrase] in *response* to and light in the marine diatom Phaeodactylum tricornutum . Positive_regulation CA12 MT-CO2 18245634 1865196 ( 5 ) in the *presence* of ( - ) , the DA-induced pHi drop is not reduced by NKCC inhibition , but rather by inhibition of the Cl ( - ) /HCO3 ( - ) exchanger ( AE ) , Na+/H+ exchanger ( NHE ) or [carbonic anhydrase] . Positive_regulation CA12 MT-CO2 19181845 2033214 In mice , responses of the olfactory sensory neurons ( OSNs ) *require* the activity of [carbonic anhydrase] to catalyze the conversion of CO(2) to bicarbonate and the opening of cGMP-sensitive ion channels . Positive_regulation CA12 MT-CO2 8330192 223535 The results support a role for [carbonic anhydrase] in trigeminal *responses* to . Positive_regulation CA12 MT-CO2 9821693 548183 Soluble [carbonic anhydrase] ( CA , EC 4.2.1.1 ) *inducible* by low levels of was purified from the unicellular green alga Chlorella sorokiniana grown at alkaline pH . Positive_regulation CA12 NBL1 24430791 104699 In Cl ( - ) -depleted thylakoids , ( - ) , *stimulated* both electron transport and [carbonic anhydrase] activity at low concentrations , while higher concentrations inhibited both . Positive_regulation CA12 PGA3 23289904 2786315 Supposedly , could *reduce* the central corneal thickness (CCT) , while topical [carbonic anhydrase] inhibitors ( TCAI ) could increase CCT . Positive_regulation CA12 PGA4 23289904 2786316 Supposedly , could *reduce* the central corneal thickness (CCT) , while topical [carbonic anhydrase] inhibitors ( TCAI ) could increase CCT . Positive_regulation CA12 PGA5 23289904 2786317 Supposedly , could *reduce* the central corneal thickness (CCT) , while topical [carbonic anhydrase] inhibitors ( TCAI ) could increase CCT . Positive_regulation CA12 PTH 12496 4570 Failure of and cyclic AMP to *inhibit* renal [carbonic anhydrase] . Positive_regulation CA12 PTH 3122585 81717 [Carbonic anhydrase] activity of chick osteoclasts is *increased* by . Positive_regulation CA12 PTH 3145673 102009 The transient increase in acidity may be due to *activation* of [carbonic anhydrase] by . Positive_regulation CA12 PTH 3937590 55280 *Stimulation* of [carbonic anhydrase] in osteoclasts by . Positive_regulation CA12 PTH 3937590 55293 Because increased fluorescence of acridine orange is a sign of greater acidity , these results suggest that ( 1 ) PTH stimulates the acidity of osteoclasts , ( 2 ) carbonic anhydrase activity is necessary for maximum acidity , and ( 3 ) [carbonic anhydrase] is *activated* by . Positive_regulation CA12 QRICH1 16653241 209623 *Induces* the N-Dependent Accumulation of mRNAs Encoding Phosphoenolpyruvate Carboxylase and [Carbonic Anhydrase] in Detached Maize Leaf Tissue . Positive_regulation CA12 QRICH2 16653241 209624 *Induces* the N-Dependent Accumulation of mRNAs Encoding Phosphoenolpyruvate Carboxylase and [Carbonic Anhydrase] in Detached Maize Leaf Tissue . Positive_regulation CA12 S100A12 16797782 1631699 *stimulates* gill [carbonic anhydrase] activity in molluscs via a common CT/CGRP receptor . Positive_regulation CA12 S100A12 9827066 550850 In gill membranes , *stimulated* the [carbonic anhydrase] activity . Positive_regulation CA12 SCT 10630386 659553 , however , did not *stimulate* [carbonic anhydrase] activity in these cells . Positive_regulation CA12 SETD2 19291313 2055991 We examined expression of CAIX , CAXII and HIF-1alpha in the developing human fetus and postnatal tissues to determine whether expression of CAIX and [CAXII] is exclusively *regulated* by . Positive_regulation CA12 SETD2 23597945 2783803 We reported that targeting these pHi regulated processes through inhibition of either *induced* [CAIX/CAXII] or HIF-1 induced MCT4 , MCT1 or Basigin/EMMPRIN/CD147 chaperone of MCTs , severely restricts glycolysis generated ATP levels and tumor growth . Positive_regulation CA2 ADRB2 9321856 456325 Recent studies have shown that *stimulated* increases in the intracellular [Ca2+] ( Cai ) transient and contraction in cardiac myocytes are dissociated from the increase in adenosine 3',5'-cyclic monophosphate ( cAMP ) level and are not accompanied by an increase in phospholamban phosphorylation , an acceleration in relaxation , or a reduction in myofilament Ca2+ response . Positive_regulation CA2 AGR2 1915840 168238 The fluorescent Ca2+ indicator Fura 2 was used to monitor [Ca2+] release *induced* by the Ins ( 1,4,5 ) P3-mobilizing agonist , caffeine and 2,5-di- ( tert-butyl ) -1,4-benzohydroquinone ( tuBHQ ) , in intact bovine adrenal chromaffin cells . Positive_regulation CA2 ALOX5 12525578 1048067 Instead , <5-LO> activation in MM6 cells *required* [Ca2+] or alternative signaling pathways induced by hyperosmotic stress . Positive_regulation CA2 ALOX5 3118366 80191 Maximal activity of human leukocyte <5-lipoxygenase> *requires* [Ca2+] , ATP , a microsomal membrane preparation , and two cytosolic stimulatory factors . Positive_regulation CA2 ALOX5 3143404 100915 [Ca2+] *induced* the membrane association of <5-lipoxygenase> when added into the incubation mixtures containing the membrane fraction with either the cytosolic fraction or the purified enzyme . Positive_regulation CA2 ALOX5 3382674 94796 Moreover , the <5-lipoxygenase> and leukotriene A4 synthase activities *require* significantly lower [Ca2+] levels for maximal activation than has been reported previously . Positive_regulation CA2 ARSA 1326693 197581 It was found that *caused* a dose dependent increase in [Ca2+i] . Positive_regulation CA2 ARSA 1326693 197582 In Ca ( 2+ ) -containing medium the [Ca2+] transient *induced* by was not affected by organic Ca2+ channel blockers , but decreased when Co2+ , Mn2+ or Zn2+ were present in the extracellular medium . Positive_regulation CA2 CA12 16777407 1665985 *Enhancement* of [Ca2+] release from limestone by microbial extracellular . Positive_regulation CA2 CA12 17316398 1699825 Na+ entry via glutamate transporter activates the reverse Na+/Ca2+ exchange and triggers *induced* [Ca2+] release in rat cerebellar Type-1 astrocytes . Positive_regulation CA2 CABP4 18003854 1827184 These findings demonstrate how light stimulated changes in phosphorylation and Ca2+ binding may *regulate* presynaptic [Ca2+] signals in photoreceptors . Positive_regulation CA2 CAPN8 10674630 667547 Taken together , these results suggest that oxidative stress induces degradation of cytoskeletal proteins presumably resulting from increased intracellular [Ca2+] concentration and subsequent *activation* of . Positive_regulation CA2 CAPN8 12173413 974449 Placenta requires 50-70 microM Ca2+ and placenta m-calpain *requires* 450-460 microM [Ca2+] for half-maximal proteolytic activity . Positive_regulation CA2 CAPN8 12951515 1137363 When expressed in COS7 cells , hnRNP K and co-localized in the cytosol , and [Ca2+-ionophore] stimulation of the cells *resulted* in proteolysis of hnRNP K , indicating that hnRNP K is an in vivo substrate for calpain . Positive_regulation CA2 CAPN8 15476820 1319571 *Activation* of by [Ca2+] : roles of the large subunit N-terminal and domain III-IV linker peptides . Positive_regulation CA2 CAPN8 17191858 1358564 Since the peptide-biphenyl hybrids reported in the present paper do not possess a reactive electrophilic functionality , we hypothesize that they interfere with the *activation* of by [Ca2+] , and present experimental and computational results on the binding of peptide-biphenyl hybrids to Ca2+ . Positive_regulation CA2 CAPN8 17360954 1734594 The molecular pathway for the unwrinkling of the leukocyte plasma membrane may involve [Ca2+] *activation* of and cleavage of cytoskeletal linkage molecules such as talin and ezrin . Positive_regulation CA2 CAPN8 1799635 176894 Leupeptin , calpain inhibitor II , and the more selective inhibitors calpeptin and MDL 28170 did not *block* the activation of the purified PKC by [Ca2+] and phosphatidylserine . Positive_regulation CA2 CAPN8 2015293 156745 The four proteolytically active forms of calpain are : ( 1 ) autolyzed , having polypeptide subunits of 76 and 18 kDa and *requiring* 0.60 microM [Ca2+] for half-maximal activity ; Positive_regulation CA2 CAPN8 23089743 2721187 [Ca2+] *activation* of cytosolic induces the transition from apoptosis to necrosis in neutrophils with externalized phosphatidylserine . Positive_regulation CA2 CAPN8 23250437 2708784 Here we demonstrate that *activation* of , a Ca2+ dependent cysteine protease , by upregulation of [Ca2+-permeable] AMPA receptors generates carboxy-terminal cleaved TDP-43 fragments and causes mislocalization of TDP-43 in the motor neurons expressing glutamine/arginine site unedited GluA2 of conditional ADAR2 knockout (AR2) mice that mimic the amyotrophic lateral sclerosis pathology . Positive_regulation CA2 CAPN8 2542320 112242 Bovine skeletal muscle *required* 40-50 microM [Ca2+] for half-maximal rate of proteolysis of a casein substrate , 140-150 microM Ca2+ for half-maximal autolysis in the presence of 80 microM phosphatidylinositol , and 190-210 microM Ca2+ for half-maximal autolysis in the absence of phosphatidylinositol . Positive_regulation CA2 CAPN8 2553696 120679 Unautolyzed , however , *required* slightly more [Ca2+] for half-maximal binding to calpastatin than for half-maximal activity . Positive_regulation CA2 CAPN8 2825780 80977 *Activation* of erythrocyte membrane [Ca2+-ATPase] by . Positive_regulation CA2 CAPN8 2829740 84858 We now demonstrate a similar kind of *activation* of the human erythrocyte membrane [Ca2+-ATPase] by ( calcium dependent neutral protease ) isolated from the human red cell cytosol . Positive_regulation CA2 CEACAM6 2085465 149162 Furthermore , can *mediate* [Ca2] ( + ) -independent , homotypic aggregation of these NCA producing transfectant cells . Positive_regulation CA2 CEACAM6 20946877 2343637 ( 60 µM ) *increased* peak sarcomere shortening and [Ca2+] transient amplitude by ~200 % and ~120 % , respectively , suggesting effects on both myofilament Ca2+ sensitivity and sarcoplasmic reticulum ( SR ) Ca2+ cycling . Positive_regulation CA2 DAPK1 18283219 1919275 *Activation* of endogenous by increasing intracellular [Ca2+] also led to increased phosphorylation of MCM3 . Positive_regulation CA2 EDN2 10101026 601964 Specific galpha11beta3gamma5 protein involvement in receptor *induced* phosphatidylinositol hydrolysis and [Ca2+] release in rat portal vein myocytes . Positive_regulation CA2 EDN2 10455291 638664 These results suggest that ET-1 ( 1-31 ) , big ET-1 and ( 1-31 ) *cause* an increase in [ [Ca2+] ] i by being converted into the corresponding ET-1 and ET-2 by NEP , but this did not occur with big ET-2 in human BSMC . Positive_regulation CA2 EDN2 12072573 956665 *induced* myoplasmic [Ca2+] responses and tyrosine phosphorylation in coronary smooth muscle . Positive_regulation CA2 EDN2 12663685 1099585 Increased *induced* [Ca2+] signaling , tyrosine phosphorylation , and coronary artery disease in diabetic dyslipidemic Swine are prevented by atorvastatin . Positive_regulation CA2 EDN2 1316352 185667 When calcium-free buffer was used , 10 nM *induced* a transient rise in [[Ca2+] ] i of lesser amplitude , whereas 0.1 nM endothelin did not produce a significant rise . Positive_regulation CA2 EDN2 1323435 192408 In addition , pretreatment with 10 microM of the Na ( + ) -H+ exchange inhibitor 5- ( N-methyl-N-isobutyl ) -amiloride significantly attenuated *induced* effects on the intracellular [Ca2+] transient and contraction during acidosis . Positive_regulation CA2 EDN2 1332560 203255 In vascular smooth muscle , binds to a specific receptor ( ETA-subtype ) , which activates phospholipase C , leads to the formation of inositol trisphosphate , diacylglycerol ( which activates protein kinase C ) , and *increased* intracellular [Ca2+] . Positive_regulation CA2 EDN2 1488271 208385 Acetylcholine did not induce a [Ca2+ ] i peak when it was applied during the *induced* [[Ca2+] ] i plateau and vice versa . Positive_regulation CA2 EDN2 1663218 173070 The protein kinase C-activator phorbol ester dose-dependently inhibited *induced* phosphoinositide turnover and intracellular free [Ca2+] increase , suggesting the involvement of protein kinase C in the regulation of endothelin induced responses . Positive_regulation CA2 EDN2 1663218 173073 Neither endothelin induced phosphoinositide hydrolysis nor *induced* increase in intracellular free [Ca2+] were affected by pertussis toxin . Positive_regulation CA2 EDN2 1706144 152992 We have investigated the effect of isoproterenol on *induced* [Ca2+] mobilization in A10 vascular smooth muscle cells . Positive_regulation CA2 EDN2 1706144 152998 It appears then that the beta-agonist isoproterenol interacts with a beta-adrenergic receptor , elevates cAMP , and thereby alters *induced* [Ca2+] mobilization . Positive_regulation CA2 EDN2 1713535 163435 The potent vasoconstrictor leads to smooth muscle cell depolarization and *increases* in intracellular [Ca2+] . Positive_regulation CA2 EDN2 1849088 153815 *induced* intracellular [Ca2+] mobilization through its specific receptors in murine peritoneal macrophages . Positive_regulation CA2 EDN2 1850199 155521 We found that myometrial smooth muscle cells in culture respond to analogues of cGMP and cAMP , as well as activators of guanylate cyclase , with a significant decrease in the resting and *induced* increase in [ [Ca2+] ] i. Treatment of human uterine smooth muscle strips with sodium nitroprusside or isoproterenol results in diminished force and frequency of contraction as well as a decrease in the rate and extent of myosin light chain phosphorylation in spontaneous contractions of human myometrium . Positive_regulation CA2 EDN2 2123967 145349 In Ca2 ( + ) -depleted vessels that were exposed to phenylephrine , PTX virtually abolished responses to Ca2+ while hardly affecting responses to [Ca2+] in the *presence* of . Positive_regulation CA2 EDN2 2245513 145872 ( 10 ( -8 ) -10 ( -7 ) mol/l ) immediately *increased* [ [Ca2+] ] i , although the increase by endothelin ( 10 ( -9 ) mol/l ) was relatively slow . Positive_regulation CA2 EDN2 2542956 112405 augments the Ca2+ induced contraction in a high-K+ depolarizing solution , markedly enhances high-threshold Ca2+-channel current on the whole-cell patch clamp recording , and *causes* a sustained increase in the intracellular [Ca2+] that is largely dependent on extracellular Ca2+ . Positive_regulation CA2 EDN2 2655594 111077 *induced* prompt and sustained increase in intracellular [Ca2+] in fura-2 loaded cells , and nicardipine inhibited this increase in intracellular Ca2+ . Positive_regulation CA2 EDN2 2656683 112906 *stimulated* an increase in intracellular [Ca2+] levels , from 100 to over 750 nM in Rat-1 cells and from 150 to over 350-nM in A10 cells as measured by fura-2 microspectrofluorimetry . Positive_regulation CA2 EDN2 2674497 117779 In Ca2+-free solution , induced a transient *increase* in [[Ca2+] ] i and a sustained contraction . Positive_regulation CA2 EDN2 2684313 121112 In guinea-pig vas deferens , taenia caeci and ileal longitudinal muscle , induced small *increases* in [[Ca2+] ] cyt and tension . Positive_regulation CA2 EDN2 7686086 219825 Ver did not alter *stimulated* [Ca2+] signalling . Positive_regulation CA2 EDN2 7931548 275308 Opioids inhibit *mediated* DNA synthesis , phosphoinositide turnover , and [Ca2+] mobilization in rat C6 glioma cells . Positive_regulation CA2 EDN2 7931548 275311 Endothelin increased the concentration of cytosolic free Ca2+ in the cells while Ab2AOR , morphine , and beta-endorphin reversed the *induced* [Ca2+] mobilization in DMI treated but not in DMI untreated C6 cells . Positive_regulation CA2 EDN2 7996790 283162 Similarly captopril reduced the [ [Ca2+] ] i increase *induced* by and vasopressin . Positive_regulation CA2 EDN2 8017648 262684 In a well characterized vascular smooth muscle cell culture model ( A7r5 and A10 ) , do the anesthetics attenuate serotonin- and *induced* [Ca2+] mobilization ? Positive_regulation CA2 EDN2 8017648 262687 Isoflurane and halothane variably attenuated contractions evoked by Ca2+ mobilizing agonists -- by a cellular action beyond the receptor level -- but did not inhibit phorbol activated protein kinase C. Serotonin- and *induced* [Ca2+] mobilization was inhibited by isoflurane and halothane -- but the mechanism does not depend upon increased cAMP . Positive_regulation CA2 EDN2 8023888 263202 Regulation of *induced* [Ca2+] mobilization in smooth muscle cells by protein kinase C . Positive_regulation CA2 EDN2 8080962 270873 *increased* [[Ca2+] ] i in cultured neurones and slices of rat hippocampus . Positive_regulation CA2 EDN2 8231641 235921 The ET-1 , and ET-3 *increased* intracellular [Ca2+] level in a dose dependent manner . Positive_regulation CA2 EDN2 8262973 239234 We now report that also *enhances* the ATP triggered [Ca2+] transient and that the effect of the combination of maximal doses of endothelin and arachidonic acid is additive . Positive_regulation CA2 EDN2 8717152 373612 Unlike ET-1 which caused an increase in cytosolic free Ca2+ at a concentration which stimulated migration , *caused* a measurable increase of cytosolic free [Ca2+] at a concentration which did not stimulate migration . Positive_regulation CA2 EDN2 8764315 374851 We conclude that growth on a collagen type I gel uncouples contractility from a proliferative response in mesangial cells , suppressing proliferation while enhancing contraction and [Ca2+] signaling in *response* to . Positive_regulation CA2 EDN2 8845071 337797 Bradykinin and induced a lesser *increase* in [[Ca2+] ] i in both the peak increase and the total amount of calcium increase during a defined period of time in tail artery EC from SHR , compared with the respective EC from WKY rats . Positive_regulation CA2 EDN2 8994441 409325 Surprisingly , *induced* increases of [Ca2+] were not different in smooth muscle of collateral and noncollateral arteries ( P > .05 ) . Positive_regulation CA2 EDN2 8994441 409328 The dissociation between *induced* contractile and [Ca2+] responses of collaterals indicates that the mechanisms involved in increasing Ca2+ sensitivity of contractile proteins during endothelin stimulation may be altered in collateral arteries . Positive_regulation CA2 EDN2 9008638 410880 receptor *mediated* [Ca2+] signaling and isoform expression in bovine corneal epithelial cells . Positive_regulation CA2 EDN2 9179872 434411 Modulation of *induced* intracellular [Ca2+] mobilization by interleukin-1 beta and lipopolysaccharide in C6 rat glioma cells . Positive_regulation CA2 EDN2 9352311 461269 receptor *mediated* [Ca2+] mobilization and contraction in bovine oviductal arteries : comparison with noradrenaline and potassium . Positive_regulation CA2 EDN2 9475175 486584 Stimulation with angiotensin-II , vasopressin , serotonin , or induced tyrosine kinase dependent *increases* in [[Ca2+] ] i . Positive_regulation CA2 EDN2 9882452 584152 *stimulated* [Ca2+] mobilization by 3T3-L1 adipocytes is suppressed by tumor necrosis factor-alpha . Positive_regulation CA2 EPHB2 12810687 1102847 We show that in stimulated CD4+ T cells , TGF-beta inhibits phosphorylation and activation of the Tec kinase Itk , increase in intracellular [Ca2+] levels , NFATc translocation , and *activation* of the mitogen activated protein kinase that together regulate T cell differentiation . Positive_regulation CA2 EPHB2 18719024 1984918 The signaling pathway requires elevated cytosolic [Ca2+] levels and *activation* of and c-Jun N-terminal protein kinase . Positive_regulation CA2 EPHB2 18854944 1994381 [Ca2+] ionophore stimulated ERK phosphorylation was *induced* in platelets without external Ca2+ , whereas exogenous Ca2+ entry was crucial for activation in Jurkat T cells . Positive_regulation CA2 EPHB2 19432968 2084109 This study shows that stimulus-transcription coupling in thrombin treated lung fibroblasts relies on the elevation of the intracellular [Ca2+-concentration] and the *activation* of PKC and . Positive_regulation CA2 EPHB2 20685979 2299171 Ca(v)3 .2 T-type [Ca2+] channel dependent *activation* of in paraventricular thalamus modulates acid induced chronic muscle pain . Positive_regulation CA2 EPHB2 9808472 545197 The sequential *activation* of and Rsk2 by [Ca2+] leads to the phosphorylation and transactivation of CREB . Positive_regulation CA2 F2R 10780319 687579 Thrombin , trypsin , and PAR-2 agonist peptides *induced* a prominent [Ca2+] response in both cell types . Positive_regulation CA2 F2R 12114324 964035 In wt LECs , thrombin or agonist peptide ( TFLLRNPNDK-NH2 ) *resulted* in a prolonged [Ca2+] transient secondary to influx of Ca2+ . Positive_regulation CA2 F2R 12716374 1083714 We assessed cytoplasmic [Ca2+] mobilization in *response* to activation with thrombin and ( SFLLRN ) and PAR4 ( GYPGKF ) peptides in two patients whose platelets were deficient in two major signalling proteins , Galphaq or phospholipase ( PLC)-beta2 . Positive_regulation CA2 F2R 21148289 2396214 , ATP , and PDGF receptor activation *resulted* in prominent nuclear [Ca 2+] signals . Positive_regulation CA2 F2R 7514596 254060 Recent studies have shown that the synthetic peptides SFL LRN and SFL LRN PND KYEPF ( thrombin receptor activating peptides ( TRAP ) ) derived from the deduced sequence of the new amino terminus of the cleaved thrombin receptor can mimic activation , act as full agonists for platelet activation , and *induce* prostaglandin I2 production as well as cytosolic [Ca2+] increase in human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation CA2 F2R 7521337 269303 Both alpha-thrombin and a 14 amino acid activating peptide *stimulate* an increase in EC [[Ca2+] ] i that is agonist dose dependent . Positive_regulation CA2 F2R 8360259 227767 activating peptides *induce* [Ca2+] mobilization , barrier dysfunction , prostaglandin synthesis , and platelet derived growth factor mRNA expression in cultured endothelium . Positive_regulation CA2 F2R 8621721 360130 However , two other activators of the , the peptide SFLLRN and trypsin , *stimulated* [Ca2+] mobilization in RBL-2H3 cells but did not cause priming . Positive_regulation CA2 F2R 9064647 414179 Thus , the control by PKC of the capacitative Ca2+ entry is apparently different depending on whether it is induced by sarco/endoplasmic reticulum [Ca2+-ATPase] inhibition or by *activation* of the . Positive_regulation CA2 F2R 9696687 524433 The effect of inositol 1,4,5-trisphosphate ( IP3 ) receptor blockade on platelet derived growth factor ( PDGF ) , fibroblast growth factor (FGF) , endothelin-1 (ET-1) , or *mediated* intracellular [Ca2+] ( Ca2+i ) release was examined using fura 2 microspectrofluorometry in single Chinese hamster ovary cells and myoblasts . Positive_regulation CA2 FAS 11160247 781560 We have previously reported that expression *requires* both protein kinase C ( PKC ) translocation and [Ca2+] mobilization and is inhibited by cyclosporin A , and dexamethasone . Positive_regulation CA2 FAS 8648106 363663 As intracellular Ca2+ release by inhibition of endoplasmic reticulum ATPases induces apoptosis in both recently and long term activated gamma delta cells , the molecular regulation of activation dependent apoptosis is likely to involve events upstream of *dependent* [Ca2+] release . Positive_regulation CA2 GLP1R 9559665 500239 expression in Xenopus oocytes *stimulates* inositol trisphosphate dependent intracellular [Ca2+] mobilization . Positive_regulation CA2 GPR115 10196220 604438 Availability of purified ECD protein should permit further structural studies to help define the mechanism of [Ca2+] *activation* of this . Positive_regulation CA2 GPR115 15845548 1418431 Thus , our results demonstrate that activation *induces* rapid FAK phosphorylation at Ser-843 through [Ca2+] , calmodulin , and CaMKII . Positive_regulation CA2 GPR115 15894006 1407724 Higher throughput screens are available such as fluorescent measurements of *induced* [Ca2+] increases or fluorescence anisotropy , yet these have limited applicability and/or low signal to noise . Positive_regulation CA2 GPR115 18452270 1908982 The sarco/endoplasmic reticulum Ca2+-ATPase ( SERCA ) , encoded by ATP2A2 , is an essential component for *dependent* [Ca2+] signaling . Positive_regulation CA2 GPR132 10196220 604427 Availability of purified ECD protein should permit further structural studies to help define the mechanism of [Ca2+] *activation* of this . Positive_regulation CA2 GPR132 15845548 1418420 Thus , our results demonstrate that activation *induces* rapid FAK phosphorylation at Ser-843 through [Ca2+] , calmodulin , and CaMKII . Positive_regulation CA2 GPR132 15894006 1407713 Higher throughput screens are available such as fluorescent measurements of *induced* [Ca2+] increases or fluorescence anisotropy , yet these have limited applicability and/or low signal to noise . Positive_regulation CA2 GPR132 18452270 1908971 The sarco/endoplasmic reticulum Ca2+-ATPase ( SERCA ) , encoded by ATP2A2 , is an essential component for *dependent* [Ca2+] signaling . Positive_regulation CA2 GPR87 10196220 604507 Availability of purified ECD protein should permit further structural studies to help define the mechanism of [Ca2+] *activation* of this . Positive_regulation CA2 GPR87 15845548 1418500 Thus , our results demonstrate that activation *induces* rapid FAK phosphorylation at Ser-843 through [Ca2+] , calmodulin , and CaMKII . Positive_regulation CA2 GPR87 15894006 1407793 Higher throughput screens are available such as fluorescent measurements of *induced* [Ca2+] increases or fluorescence anisotropy , yet these have limited applicability and/or low signal to noise . Positive_regulation CA2 GPR87 18452270 1909051 The sarco/endoplasmic reticulum Ca2+-ATPase ( SERCA ) , encoded by ATP2A2 , is an essential component for *dependent* [Ca2+] signaling . Positive_regulation CA2 HRH1 22563449 2596182 Desipramine inhibits *induced* [Ca2+] signaling in rat hypothalamic cells . Positive_regulation CA2 HRH1 8831720 385822 *induced* [Ca2+] mobilization and prostaglandin E2 release in human gingival fibroblasts . Positive_regulation CA2 HRH1 9652346 515836 Fenspiride ( 10 ( -7 ) -10 ( -5 ) M ) inhibited the *induced* [Ca2+] increase . Positive_regulation CA2 IL1B 10593617 572718 *increased* [ [Ca2+] ] i levels in a dose and time dependent manner . Positive_regulation CA2 IL1B 11171124 783851 *enhances* bradykinin induced phosphoinositide hydrolysis and [Ca2+] mobilization in canine tracheal smooth-muscle cells : involvement of the Ras/Raf/mitogen activated protein kinase (MAPK) kinase ( MEK ) /MAPK pathway . Positive_regulation CA2 IL1B 17670890 1794013 Mechanisms of *induced* [Ca2+] signals in mouse cortical astrocytes : roles of store- and receptor operated Ca2+ entry . Positive_regulation CA2 IL1B 8075863 270615 3. A linear and significant correlation was observed between the increase in [ [Ca2+] ] *induced* by and the rise in body temperature . Positive_regulation CA2 IL1B 8842435 387269 1. Previous observations that centrally injected interleukin-1 beta (IL-1 beta) into rabbits induces a sustained rise in cerebrospinal fluid (CSF) Ca2+ concentration ([Ca2+]) as well as fever , prompted us to undertake an in vitro study to corroborate the in vivo results and gain insight as to the source and mechanism of *induced* [Ca2+] mobilization . Positive_regulation CA2 IL1B 9462702 485232 *induced* the increase of intracellular [Ca2+] and IP3 concentrations in the HSCs , which were decreased by OPC-15161 . Positive_regulation CA2 ITGAL 19542227 2116374 Using membrane vesicles expressing the mouse class I major histocompatibility complex , i.e. Ld plus costimulatory ligands , i.e . B7-1 and intercellular adhesion molecule-1 along with 2C T cell receptor transgenic T cells , we investigated the *roles* of CD28 and ( lymphocyte function associated antigen-1 ) in the activation of PLC-gamma1 and [Ca2+] signaling . Positive_regulation CA2 ITGB2 1361124 206162 Monoclonal antibody ( mAb ) cross linking of , the integrin beta subunit ubiquitously expressed by all leukocytes , *increased* the cytosolic free [Ca2+ concentration ([Ca2+]i)] by 2-3-fold in monocyte THP-1 cells . Positive_regulation CA2 ITGB2 1361124 206163 Cross linking of also *increased* cytosolic free [ Ca2+ ] i in a subset of approx. 15-20 % of resting T lymphocytes , in a [Ca2+] response that was completely abrogated during T-cell mitogenic activation with lectins or alloreactive antigen . Positive_regulation CA2 ITGB2 19542227 2116383 These results ensure the unique *role* of in T cell [Ca2+] signaling and reveal that LFA-1 dependent Ca2+ entry proceeds via a mechanism separate from store operated Ca2+ entry . Positive_regulation CA2 ITGB2 7525820 277015 Cross linking of in human neutrophils *induces* an increase of intracellular free [Ca2+] , exocytosis of azurophilic granules , quantitative up-regulation of CD18 , shedding of L-selectin , and actin polymerization . Positive_regulation CA2 MAP2K6 11748587 889663 The retrovirally transfected CCK ( B ) /gastrin receptor binds 125I-CCK-8 with high affinity ( Kd = 1.1 nM ) and is functionally coupled to intracellular signaling pathways including rapid and transient increase in [Ca2+] fluxes , protein kinase C-dependent protein kinase D activation , and dependent ERK1/2 *activation* . Positive_regulation CA2 MUC16 9032127 414768 We conclude that release by ATP does not *require* an increase in the intracellular [Ca2+] level but involves the activation of protein kinase C . Positive_regulation CA2 NT5E 6270857 16971 The phosphatase and <5'-nucleotidase> are shown to be *activated* by Mg2+ and [Ca2+] . Positive_regulation CA2 PADI3 3711070 60256 *required* millimolar [Ca2+] for the binding to STI-Sepharose . Positive_regulation CA2 PCSK9 8306412 249049 The endonuclease activity of VP-16 treated N231 , but not , cells *required* both [Ca2+] and Mg2+ for full activity . Positive_regulation CA2 PGC 12665481 1074760 In this study , we tested the hypothesis that raising cytosolic [Ca2+] in L6 myotubes *induces* increased expression of , NRF-1 , NRF-2 , and mtTFA , factors that have been implicated in mitochondrial biogenesis and in the adaptation of muscle to exercise . Positive_regulation CA2 PLAU 10491182 646286 The *induced* increase in intracellular [Ca2+] was independent of uPA proteolytic activity . Positive_regulation CA2 S1PR3 10220556 609242 When H218 and were stably expressed in rat HTC4 hepatoma cells , S1P *induced* [Ca2+] responses with nanomolar EC50 values . Positive_regulation CA2 S1PR3 17184732 1679927 Overexpression of S1P2 , or , but not S1P1 , *leads* to a significant increase in cytosolic and mitochondrial [ [Ca2+] ] in response to S1P challenge . Positive_regulation CA2 SCIN 1331119 200267 *Activation* of by [Ca2+] may cause disassembly of actin filaments leaving cortical areas of low cytoplasmic viscosity which are the sites of exocytosis ( Vitale , M. L. , A. Rodríguez Del Castillo , L. Tchakarov , and J.-M . Positive_regulation CA2 SELL 7518434 261858 The *role* of in ROI production and [Ca2+] signaling in suspended neutrophils was examined using the DREG series of anti-L-selectin antibodies . Positive_regulation CA2 SELL 7541041 310259 In particular , cross linking *leads* to increased cytosolic [Ca2+] levels and potentiation of the oxidative burst . Positive_regulation CA2 SELL 9087605 421675 Cross linking of canine neutrophil using anti-L-selectin antibody induced a rapid and transient *increase* in intracellular [Ca2+] levels and superoxide anion generation that were dependent on the extent of L-selectin cross linking . Positive_regulation CA2 SLC38A3 10362639 620092 *induced* [Ca2+] mobilization in both the GH3 and AR42J cells . Positive_regulation CA2 SLC38A3 14602717 1187565 activation of the cholecystokinin/gastrin receptor ( CCK ( 2 ) R ) , a G protein coupled receptor , *stimulates* release of [Ca2+] from inositol 1,4,5-triphosphate-sensitive Ca2+ stores . Positive_regulation CA2 SLC38A3 14602717 1187572 Activation of the MEK1 ,2/ERK1,2 pathway either by pretreating cells with EGF or by expression of constitutively active K-ras ( K-rasV12G ) or MEK1 (MEK1*) increased the amplitude of *stimulated* [Ca2+] release . Positive_regulation CA2 SNCAIP 10788802 689021 In contrast , *induced* intracellular [Ca(2)] ( + ) mobilization was suppressed by pertussis toxin , but not at all by C3 exoenzyme . Positive_regulation CA2 SNCAIP 11602242 870965 The effect appears to be specific as neither ceramide nor *had* any effect on the NO and [[Ca2+] ] i levels . Positive_regulation CA2 SNCAIP 7795224 313580 *induced* intracellular [Ca2+] mobilization and the dose-response for Ca2+ release correlated closely with the concentration required for induction of shape change . Positive_regulation CA2 SPHK1 10493910 646775 Lysophosphatidic acid mediated [Ca2+] mobilization in human SH-SY5Y neuroblastoma cells is independent of phosphoinositide signalling , but *dependent* on activation . Positive_regulation CA2 SPHK1 11392623 823072 On the basis of these studies we propose , that following initial IP3 production by receptor mediated PLC activation , a local discrete increase in [ [Ca2+] ] i *induces* stimulation , which ultimately leads to full calcium mobilization . Positive_regulation CA2 SPHK1 9582276 503820 *mediated* [Ca2+] signalling by G-protein coupled receptors . Positive_regulation CA2 SPHK1 9582276 503822 The present study investigated whether activation , leading to production of sphingosine-1-phosphate (SPP) , is *involved* in GPCR mediated [Ca2+] signalling as proposed for platelet derived growth factor and FcepsilonRI antigen receptors . Positive_regulation CA2 SPHK1 9582276 503826 As [Ca2+] signalling by various , but not all , GPCRs in different cell types was likewise *attenuated* by the inhibitors , we suggest a general role for sphingosine kinase , besides PLC , in mediation of GPCR induced Ca2+ signalling . Positive_regulation CA2 SYT8 8285596 247482 Findings are similar to those in human Lambert-Eaton myasthenic syndrome and passively transferred Lambert-Eaton myasthenic syndrome in mice , and thus suggest that antibody to a *dependent* [Ca2+] channel complex may be involved in the pathogenesis of Lambert-Eaton myasthenic syndrome . Positive_regulation CA2 TF 9461291 475786 Consequently , we examined the *role* of in internal free [Ca2+] regulation . Positive_regulation CA2 TGM2 23049776 2684886 Gliadin peptides *induce* activation and ER-stress through [Ca2+] mobilization in Caco-2 cells . Positive_regulation CA2 TGM2 2572608 120869 [45Ca2+] uptake , *activation* of Ca2+ dependent , and products of the crosslinking reaction were measured . Positive_regulation CA2 TGM2 2869797 55617 Membrane phospholipids , 1,2-diolein and calmodulin were found not to affect the *activation* of by [Ca2+] . Positive_regulation CA2 TGM2 9792706 542704 The modification of LAV1-2 may lead to localized release of [Ca2+] and *activation* of for walling off damaged areas of plasmodia . Positive_regulation CA2 TMOD1 2455798 93542 1. Maximum shortening velocity ( Vmax ) was examined in skinned single fibres from rat slow-twitch soleus muscles at various degrees of [Ca2+] *activation* of the , in the presence and absence of osmotic compression induced by 5 % dextran . Positive_regulation CA2 TMOD1 9553120 499522 Our results show the following : ( i ) the NH2-terminal region of troponin T activates the actomyosin ATPase in the presence of tropomyosin; (ii) the interaction of the globular domain of troponin T with the *blocks* ATPase activation in the absence of [Ca2+] ; Positive_regulation CA2 TNF 11082216 753404 [Ca2+] release from intracellular stores was strongly *stimulated* by acetylcholine (ACh) and ATP , but not by norepinephrine ( NA ) , epidermal growth factor (EGF) , interleukin-6 (IL-6) , and . Positive_regulation CA2 TNF 12671298 480017 induces oxygen radicals in mitochondria through ceramides , and the recently discovered mitochondrial nitric oxide synthase profoundly *stimulates* [Ca2+] release from mitochondria through formation of nitrogen monoxide and peroxynitrite . Positive_regulation CA2 TNF 1666506 176530 *induced* rapid elevation of intercellular [Ca2+] level in all studied cells . Positive_regulation CA2 TNF 1847937 153534 IL-1 and *caused* rapid , transient , and concentration dependent increases in cytosolic free [Ca2+] . Positive_regulation CA2 TNF 18550705 1945933 Mechanical stress *induces* { alpha } production through [Ca2+] release dependent TLR2 signaling . Positive_regulation CA2 TNF 19922794 2184724 Herein , we describe regulation inherent to 3xTg-AD neurons , which results in the loss of *mediated* enhancement of inositol 1,4,5 trisphosphate ( IP3R ) -mediated [Ca2+] release . Positive_regulation CA2 TNF 7578678 329225 In conclusion , *induces* transient increases in [ [Ca2+] ] i by transmembrane Ca2+ flux , which are suppressed during cytodifferentiation . Positive_regulation CA2 TNF 8660944 371783 These findings suggest that TPT increases intracellular [Ca2+] , alters actin polymerization and the cytoskeleton , and *induces* NF-kappaB activation , synthesis , DNA degradation , and apoptosis . Positive_regulation CA2 TNF 9010006 405066 We conclude that *induces* an increase of intracellular [Ca2+] and a depolarization in astrocytes with the consequence of disturbing voltage dependent glial functions such as regulation of local ion concentrations and glutamate uptake . Positive_regulation CA2 TNF 9915989 587443 We previously demonstrated that *induces* a small , delayed follicular stage dependent increase in intracellular [Ca2+ concentration ([Ca2+]i)] in hen granulosa cells and promotes carbachol ( Cch ) -induced mobilization of Ca2+ from intracellular stores in cells otherwise unresponsive to the cytokine . Positive_regulation CA2 TNF 9915989 587444 The focus of the current study was to examine the role of ceramide in *induced* [Ca2+] regulation . Positive_regulation CA2 TNNT2 12479243 1023957 However , the relative magnitude of the increase in [Ca2+-sensitivity] *induced* by the mutant increased as the pH was decreased from pH 7.5 to pH 7.0 and to pH 6.5 . Positive_regulation CA3 RGS16 19225179 2061775 protein suppression of Galphao protein *mediated* alpha2A adrenergic receptor inhibition of mouse hippocampal [CA3] epileptiform activity . Positive_regulation CA3 RGS2 19225179 2061776 protein suppression of Galphao protein *mediated* alpha2A adrenergic receptor inhibition of mouse hippocampal [CA3] epileptiform activity . Positive_regulation CA4 CTGF 19208742 2039193 Furthermore , [CA-4P] *induced* expression in endothelial cells , forming tube-like structures on basement membrane gels . Positive_regulation CA5A EPHB2 17996937 1903199 Thus , *dependent* regulation of [Ca(v)] activity provides an elegant and extremely flexible system with which to tailor calcium influx to discrete functional demands . Positive_regulation CA5A TNF 20603027 2286240 After challenge with either 30 microg/kg or 60 microg/kg BW PG-PS , *increased* in the posterior vena [cava] . Positive_regulation CA8 ANKRD1 12524226 1047894 ( CARP ) expression in human and murine atherosclerotic lesions : activin *induces* [CARP] in smooth muscle cells . Positive_regulation CA9 EPHB2 16270297 1502360 Constitutively increased activity in isogenic fibrosarcoma cell lines did not *cause* increased cell density dependent [CAIX] expression/CA9 promoter activity . Positive_regulation CA9 EPHB2 16270297 1502362 Thus , although signaling is *required* for optimal [CAIX] expression , our data are consistent with a model in which constitutive basal ERK activity plays an auxiliary role in CA9 promoter transactivation by modulating activity of the transcription factor SP1 and the transcriptional co-activator p300 . Positive_regulation CA9 TNF 22724087 2616764 Continuous stimulation with the cytokines , IL-1 , IL-6 , and TGF-ß , under normoxic conditions significantly *increased* the [carbonic anhydrase 9] expression level at both the protein and mRNA level , almost doubling the CA9 mRNA and CA9 and HIF-1a protein expression levels found under hypoxia . Positive_regulation CABP4 BDNF 14625444 1170204 Using BDNF null mutant (BDNF-/-) mice and mice where the protein coding DNA sequence of BDNF has been replaced by NT3 ( BDNFNT3/NT3 mice ) , we have analysed the *roles* of and NT3 in controlling neuropeptide and [calcium binding protein] expression in the brain . Positive_regulation CABP4 CALM3 9272432 450580 In the present study , we have investigated the expression of the *dependent* phosphatase , calcineurin , and the EF-hand [calcium binding protein] , calretinin , in pancreata of hamsters , gerbils , and rats by immunocytochemistry . Positive_regulation CABP4 MDK 10096022 560683 Disruption of the *resulted* in altered expression of a [calcium binding protein] in the hippocampus of infant mice and their abnormal behaviour . Positive_regulation CABP4 NTF3 7805287 284686 In this study we have examined the [calcium binding protein] expression in rat embryonic ( E16 ) dorsal root ganglia (DRG) neurons in vitro in the *presence* of . Positive_regulation CABP4 RGN 2279298 147447 The effect of heparin on the [calcium binding protein] *stimulated* Ca2+ release from rat liver microsomes was investigated . Positive_regulation CABP4 S100G 12520541 1047788 The transcellular process involves three major steps : entry across the brush border , mediated by a molecular structure termed CaT1 , intracellular diffusion , *mediated* largely by the cytosolic [calcium binding protein] ( or CaBP ) ; Positive_regulation CABP4 SORT1 14625444 1170205 Using BDNF null mutant (BDNF-/-) mice and mice where the protein coding DNA sequence of BDNF has been replaced by NT3 ( BDNFNT3/NT3 mice ) , we have analysed the *roles* of BDNF and in controlling neuropeptide and [calcium binding protein] expression in the brain . Positive_regulation CACNA1A AGR2 14640758 1171730 In substituting Ag(2)O for MnO ( 2 ) to accomplish the selective destruction of H ( 2 ) O ( 2 ) , we achieved the stated objective but were puzzled by a 3-fold increase in the [MHP] response in the *presence* of . Positive_regulation CACNB1 IL1B 11146166 758909 A total of 14 clones could be matched to known genes and were categorized into four groups : A ) transcription factors : prothymosin , CA150 , p78 serine/threonine kinase , *stimulating* gene , glucocorticoid receptor , [MLN64/CAB1] , gastrin binding protein , and polypeptide from glioblastoma ; Positive_regulation CAD EPHB2 10514499 651851 and 3 ) suggest a functional role for *dependent* [l-CaD] phosphorylation in cell division . Positive_regulation CAD PLAU 19500428 2098116 The staurosporine mediated inhibition of PKC-alpha , *induction* of [E-Cad] expression , and decreased integrin beta1 , LnR , MMP-9 , and levels could all possibly contribute to this biological process . Positive_regulation CADM1 FAS 16316466 1493949 When compared to WT , mutant astrocytes displayed an overall increased constitutive gelatinase expression and were less responsive to *mediated* upregulation of MMP-9 , of monocyte chemoattractant protein-1 ( MCP-1 ) and of intercellular [cell adhesion molecule-1] ( ICAM-1 ) , all markers of astrocyte inflammatory response . Positive_regulation CADM1 IL1B 17349082 1707994 Ellagic acid inhibits *induced* [cell adhesion molecule] expression in human umbilical vein endothelial cells . Positive_regulation CADM1 IL1B 19937041 2280701 Chlorogenic acid dose-dependently suppressed *induced* mRNA expression of vascular cell adhesion molecule-1 , intercellular [cell adhesion molecule-1] and endothelial cell selectin . Positive_regulation CADM1 IL1B 9409229 471426 In cultured human smooth muscle cells from coronary arteries and saphenous veins , tumor necrosis factor-alpha (TNF-alpha) and *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular [cell adhesion molecule] ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation CADM1 SELL 11404363 842975 Following the recent description of the affinity and kinetics of the selectin-ligand pairs *dependent* [cell adhesion molecule-1] and P-selectin-P-selectin glycoprotein ligand-1 , this is the first determination of the parameters of E-selectin binding to one of its naturally occurring ligands . Positive_regulation CADM1 TNF 10580548 570093 *Induction* of intercellular adhesion molecule ( ICAM-1 ) , vascular [cell adhesion molecule] ( VCAM-1 ) and E-selectin by , measured by a radiometric technique , was similar in IVEC and HUVEC , while the induction of E-selectin by IL-1beta on IVEC was limited and significantly different from that observed on HUVEC ( p < 0.001 ) . Positive_regulation CADM1 TNF 12372676 996459 Although zofenoprilat significantly and dose dependently reduced the expression of vascular cell adhesion molecule-1 ( VCAM-1 ) , intercellular [cell adhesion molecule-1] ( ICAM-1 ) , and E-selectin *induced* by ox-LDL ( P < .01 ) and ( P < .01 ) on HUVECs , enalaprilat did not . Positive_regulation CADM1 TNF 12893683 1135173 Ginkgo biloba extract inhibits *induced* reactive oxygen species generation , transcription factor activation , and [cell adhesion molecule] expression in human aortic endothelial cells . Positive_regulation CADM1 TNF 15068815 1232315 Pretreatment of HUVEC with butyrate inhibited *induced* expression of vascular cell adhesion molecule-1 ( VCAM-1 ) and intracellular [cell adhesion molecule-1] ( ICAM-1 ) in a time and concentration dependent manner . Positive_regulation CADM1 TNF 15576639 1361308 Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular [cell adhesion molecule-1] *induced* by in human endothelial cells through the JNK/p38 pathways . Positive_regulation CADM1 TNF 15576639 1361316 SOD expression significantly suppressed *induced* expression of vascular cell adhesion molecule-1 and intercellular [cell adhesion molecule-1] and reduced the binding of the human neutrophils to TNF-alpha stimulated HAECs . Positive_regulation CADM1 TNF 15742809 1378889 Manassantin A and B isolated from Saururus chinensis inhibit *induced* [cell adhesion molecule] expression of human umbilical vein endothelial cells . Positive_regulation CADM1 TNF 16271738 1502443 CKS significantly inhibited the *induced* increase in monocyte adhesion to endothelial cells as well as decreased the protein and mRNA expression levels of vascular adhesion molecule-1 and intercellular [cell adhesion molecule-1] on endothelial cells . Positive_regulation CADM1 TNF 18202320 1883811 FIR radiation also inhibited *mediated* expression of E-selectin , vascular cell adhesion molecule-1 , intercellular [cell adhesion molecule-1] , monocyte chemoattractant protein-1 , interleukin-8 , and the cytokine mediated adhesion of monocytes to ECs . Positive_regulation CADM1 TNF 19439196 2101371 Experimental results indicated that 2-TeCD suppressed the *induced* the expression of vascular adhesion molecule-1 (VCAM-1) and intercellular [cell adhesion molecule-1] ( ICAM-1 ) on HUVECs surface in a dose dependent manner . Positive_regulation CADM1 TNF 19765578 2153526 induced mRNA *induction* of the chemokines , monocyte chemoattractant protein (MCP)-1 and interleukin (IL)-8 , and the intercellular [cell adhesion molecule] ( ICAM)-1 , which are involved in adhesion between leukocytes and epithelial cells , was suppressed by M1-M4 , and M1 was the most efficacious . Positive_regulation CADM1 TNF 20091890 2212748 This study aimed to investigate whether ACSO could modulate *induced* expression of intercellular [cell adhesion molecule-1] , monocyte adhesion and TNF-alpha mediated signaling in human umbilical vein endothelial cells . Positive_regulation CADM1 TNF 20091890 2212749 While *promoted* the intercellular [cell adhesion molecule-1] mRNA transcription in a dose- and time dependent manner , ACSO treatment significantly reduced the levels of TNF-alpha induced intercellular cell adhesion molecule-1 mRNA transcripts ( P < 0.01 ) . Positive_regulation CADM1 TNF 20306475 2315260 When HAECs were pretreated with sesamin ( 10 or 100 microM ) , the *induced* expression of intercellular [cell adhesion molecule-1] ( ICAM-1 ) was significantly reduced ( 35 or 70 % decrease , respectively ) by Western blotting . Positive_regulation CADM1 TNF 20465310 2268808 markedly *induced* protein expression of [cell adhesion molecule] and E-selectin with increasing mRNA levels in HUVEC . Positive_regulation CADM1 TNF 20558233 2302437 beta-sitosterol among other secondary metabolites of Piper galeatum shows inhibition of *induced* [cell adhesion molecule] expression on human endothelial cells . Positive_regulation CADM1 TNF 20966395 2365255 By using human umbilical vein endothelial cells ( HUVECs ) , we showed that Erg overexpression by adenovirus ( AdErg ) repressed basal and *induced* expression of intercellular adhesion molecule-1 ( ICAM-1 ) , vascular [cell adhesion molecule] ( VCAM ) , and interleukin 8 (IL-8) . Positive_regulation CADM1 TNF 22751795 2676266 Flavonoid extract was effective in inhibiting expression of intercellular adhesion molecule-1 ( ICAM-1 ) and vascular [cell adhesion molecule] ( VCAM-1 ) *induced* by in HUVECs . Positive_regulation CADM1 TNF 23317476 2870149 Whereas IRW significantly inhibited induced *up-regulation* of intercellular [cell adhesion molecule-I] ( ICAM-1 ) and vascular cell adhesion molecule-I ( VCAM-1 ) , IQW could inhibit only the up-regulation of ICAM-1 . Positive_regulation CADM1 TNF 24333719 2910829 released from LPS treated monocytes *triggered* the expression of intercellular [cell adhesion molecule-1] ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) on endothelial cells . Positive_regulation CADM1 TNF 7532667 292157 We found that treatment of ASM with either forskolin , which directly activates adenylyl cyclase , or with cholera toxin , which activates the heterotrimeric GTP binding protein , Gs , inhibited *induced* [cell adhesion molecule] expression . Positive_regulation CADM1 TNF 7680963 214186 Flow cytometric analyses revealed that murine microvascular endothelium (MME) in culture constitutively expresses VCAM-1 and that stimulation of MME by , IL-1 , or LPS , but not by PMA or staurosporine , strongly *increased* the surface expression of this [cell adhesion molecule] . Positive_regulation CADM1 TNF 8666424 369089 but not the other human cytokines unregulated swine leucocyte antigens (SLA) class I , class II and B7 receptor expression and *induced* vascular [cell adhesion molecule] ( VCAM ) and E-selectin expression . Positive_regulation CADM1 TNF 9409229 471423 In cultured human smooth muscle cells from coronary arteries and saphenous veins , and interleukin-1 beta (IL-1 beta) *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular [cell adhesion molecule] ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation CADM2 IL1B 17349082 1707992 Ellagic acid inhibits *induced* [cell adhesion molecule] expression in human umbilical vein endothelial cells . Positive_regulation CADM2 IL1B 9409229 471398 In cultured human smooth muscle cells from coronary arteries and saphenous veins , tumor necrosis factor-alpha (TNF-alpha) and *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular [cell adhesion molecule] ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation CADM2 TNF 10580548 570086 *Induction* of intercellular adhesion molecule ( ICAM-1 ) , vascular [cell adhesion molecule] ( VCAM-1 ) and E-selectin by , measured by a radiometric technique , was similar in IVEC and HUVEC , while the induction of E-selectin by IL-1beta on IVEC was limited and significantly different from that observed on HUVEC ( p < 0.001 ) . Positive_regulation CADM2 TNF 12893683 1135170 Ginkgo biloba extract inhibits *induced* reactive oxygen species generation , transcription factor activation , and [cell adhesion molecule] expression in human aortic endothelial cells . Positive_regulation CADM2 TNF 15742809 1378887 Manassantin A and B isolated from Saururus chinensis inhibit *induced* [cell adhesion molecule] expression of human umbilical vein endothelial cells . Positive_regulation CADM2 TNF 19765578 2153524 induced mRNA *induction* of the chemokines , monocyte chemoattractant protein (MCP)-1 and interleukin (IL)-8 , and the intercellular [cell adhesion molecule] ( ICAM)-1 , which are involved in adhesion between leukocytes and epithelial cells , was suppressed by M1-M4 , and M1 was the most efficacious . Positive_regulation CADM2 TNF 20465310 2268806 markedly *induced* protein expression of [cell adhesion molecule] and E-selectin with increasing mRNA levels in HUVEC . Positive_regulation CADM2 TNF 20558233 2302435 beta-sitosterol among other secondary metabolites of Piper galeatum shows inhibition of *induced* [cell adhesion molecule] expression on human endothelial cells . Positive_regulation CADM2 TNF 20966395 2365252 By using human umbilical vein endothelial cells ( HUVECs ) , we showed that Erg overexpression by adenovirus ( AdErg ) repressed basal and *induced* expression of intercellular adhesion molecule-1 ( ICAM-1 ) , vascular [cell adhesion molecule] ( VCAM ) , and interleukin 8 (IL-8) . Positive_regulation CADM2 TNF 22751795 2676263 Flavonoid extract was effective in inhibiting expression of intercellular adhesion molecule-1 ( ICAM-1 ) and vascular [cell adhesion molecule] ( VCAM-1 ) *induced* by in HUVECs . Positive_regulation CADM2 TNF 7532667 292155 We found that treatment of ASM with either forskolin , which directly activates adenylyl cyclase , or with cholera toxin , which activates the heterotrimeric GTP binding protein , Gs , inhibited *induced* [cell adhesion molecule] expression . Positive_regulation CADM2 TNF 7680963 214180 Flow cytometric analyses revealed that murine microvascular endothelium (MME) in culture constitutively expresses VCAM-1 and that stimulation of MME by , IL-1 , or LPS , but not by PMA or staurosporine , strongly *increased* the surface expression of this [cell adhesion molecule] . Positive_regulation CADM2 TNF 8666424 369087 but not the other human cytokines unregulated swine leucocyte antigens (SLA) class I , class II and B7 receptor expression and *induced* vascular [cell adhesion molecule] ( VCAM ) and E-selectin expression . Positive_regulation CADM2 TNF 9409229 471395 In cultured human smooth muscle cells from coronary arteries and saphenous veins , and interleukin-1 beta (IL-1 beta) *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular [cell adhesion molecule] ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation CADM3 IL1B 17349082 1707991 Ellagic acid inhibits *induced* [cell adhesion molecule] expression in human umbilical vein endothelial cells . Positive_regulation CADM3 IL1B 9409229 471394 In cultured human smooth muscle cells from coronary arteries and saphenous veins , tumor necrosis factor-alpha (TNF-alpha) and *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular [cell adhesion molecule] ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation CADM3 TNF 10580548 570085 *Induction* of intercellular adhesion molecule ( ICAM-1 ) , vascular [cell adhesion molecule] ( VCAM-1 ) and E-selectin by , measured by a radiometric technique , was similar in IVEC and HUVEC , while the induction of E-selectin by IL-1beta on IVEC was limited and significantly different from that observed on HUVEC ( p < 0.001 ) . Positive_regulation CADM3 TNF 12893683 1135167 Ginkgo biloba extract inhibits *induced* reactive oxygen species generation , transcription factor activation , and [cell adhesion molecule] expression in human aortic endothelial cells . Positive_regulation CADM3 TNF 15742809 1378886 Manassantin A and B isolated from Saururus chinensis inhibit *induced* [cell adhesion molecule] expression of human umbilical vein endothelial cells . Positive_regulation CADM3 TNF 19765578 2153523 *induced* mRNA induction of the chemokines , monocyte chemoattractant protein (MCP)-1 and interleukin (IL)-8 , and the intercellular [cell adhesion molecule] ( ICAM)-1 , which are involved in adhesion between leukocytes and epithelial cells , was suppressed by M1-M4 , and M1 was the most efficacious . Positive_regulation CADM3 TNF 20465310 2268805 markedly *induced* protein expression of [cell adhesion molecule] and E-selectin with increasing mRNA levels in HUVEC . Positive_regulation CADM3 TNF 20558233 2302434 beta-sitosterol among other secondary metabolites of Piper galeatum shows inhibition of *induced* [cell adhesion molecule] expression on human endothelial cells . Positive_regulation CADM3 TNF 20966395 2365251 By using human umbilical vein endothelial cells ( HUVECs ) , we showed that Erg overexpression by adenovirus ( AdErg ) repressed basal and *induced* expression of intercellular adhesion molecule-1 ( ICAM-1 ) , vascular [cell adhesion molecule] ( VCAM ) , and interleukin 8 (IL-8) . Positive_regulation CADM3 TNF 22751795 2676262 Flavonoid extract was effective in inhibiting expression of intercellular adhesion molecule-1 ( ICAM-1 ) and vascular [cell adhesion molecule] ( VCAM-1 ) *induced* by in HUVECs . Positive_regulation CADM3 TNF 7532667 292154 We found that treatment of ASM with either forskolin , which directly activates adenylyl cyclase , or with cholera toxin , which activates the heterotrimeric GTP binding protein , Gs , inhibited *induced* [cell adhesion molecule] expression . Positive_regulation CADM3 TNF 7680963 214177 Flow cytometric analyses revealed that murine microvascular endothelium (MME) in culture constitutively expresses VCAM-1 and that stimulation of MME by , IL-1 , or LPS , but not by PMA or staurosporine , strongly *increased* the surface expression of this [cell adhesion molecule] . Positive_regulation CADM3 TNF 8666424 369086 but not the other human cytokines unregulated swine leucocyte antigens (SLA) class I , class II and B7 receptor expression and *induced* vascular [cell adhesion molecule] ( VCAM ) and E-selectin expression . Positive_regulation CADM3 TNF 9409229 471391 In cultured human smooth muscle cells from coronary arteries and saphenous veins , and interleukin-1 beta (IL-1 beta) *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular [cell adhesion molecule] ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation CADM4 IL1B 17349082 1707993 Ellagic acid inhibits *induced* [cell adhesion molecule] expression in human umbilical vein endothelial cells . Positive_regulation CADM4 IL1B 9409229 471402 In cultured human smooth muscle cells from coronary arteries and saphenous veins , tumor necrosis factor-alpha (TNF-alpha) and *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular [cell adhesion molecule] ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation CADM4 TNF 10580548 570087 *Induction* of intercellular adhesion molecule ( ICAM-1 ) , vascular [cell adhesion molecule] ( VCAM-1 ) and E-selectin by , measured by a radiometric technique , was similar in IVEC and HUVEC , while the induction of E-selectin by IL-1beta on IVEC was limited and significantly different from that observed on HUVEC ( p < 0.001 ) . Positive_regulation CADM4 TNF 12893683 1135171 Ginkgo biloba extract inhibits *induced* reactive oxygen species generation , transcription factor activation , and [cell adhesion molecule] expression in human aortic endothelial cells . Positive_regulation CADM4 TNF 15742809 1378888 Manassantin A and B isolated from Saururus chinensis inhibit *induced* [cell adhesion molecule] expression of human umbilical vein endothelial cells . Positive_regulation CADM4 TNF 19765578 2153525 *induced* mRNA induction of the chemokines , monocyte chemoattractant protein (MCP)-1 and interleukin (IL)-8 , and the intercellular [cell adhesion molecule] ( ICAM)-1 , which are involved in adhesion between leukocytes and epithelial cells , was suppressed by M1-M4 , and M1 was the most efficacious . Positive_regulation CADM4 TNF 20465310 2268807 markedly *induced* protein expression of [cell adhesion molecule] and E-selectin with increasing mRNA levels in HUVEC . Positive_regulation CADM4 TNF 20558233 2302436 beta-sitosterol among other secondary metabolites of Piper galeatum shows inhibition of *induced* [cell adhesion molecule] expression on human endothelial cells . Positive_regulation CADM4 TNF 20966395 2365253 By using human umbilical vein endothelial cells ( HUVECs ) , we showed that Erg overexpression by adenovirus ( AdErg ) repressed basal and *induced* expression of intercellular adhesion molecule-1 ( ICAM-1 ) , vascular [cell adhesion molecule] ( VCAM ) , and interleukin 8 (IL-8) . Positive_regulation CADM4 TNF 22751795 2676264 Flavonoid extract was effective in inhibiting expression of intercellular adhesion molecule-1 ( ICAM-1 ) and vascular [cell adhesion molecule] ( VCAM-1 ) *induced* by in HUVECs . Positive_regulation CADM4 TNF 7532667 292156 We found that treatment of ASM with either forskolin , which directly activates adenylyl cyclase , or with cholera toxin , which activates the heterotrimeric GTP binding protein , Gs , inhibited *induced* [cell adhesion molecule] expression . Positive_regulation CADM4 TNF 7680963 214183 Flow cytometric analyses revealed that murine microvascular endothelium (MME) in culture constitutively expresses VCAM-1 and that stimulation of MME by , IL-1 , or LPS , but not by PMA or staurosporine , strongly *increased* the surface expression of this [cell adhesion molecule] . Positive_regulation CADM4 TNF 8666424 369088 but not the other human cytokines unregulated swine leucocyte antigens (SLA) class I , class II and B7 receptor expression and *induced* vascular [cell adhesion molecule] ( VCAM ) and E-selectin expression . Positive_regulation CADM4 TNF 9409229 471399 In cultured human smooth muscle cells from coronary arteries and saphenous veins , and interleukin-1 beta (IL-1 beta) *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular [cell adhesion molecule] ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation CALB2 NT5E 7874306 287527 In cultures prepared from rats of embryonic day 15 , strongly *increased* the number of calretinin positive cells as well as [calretinin] levels , as determined by Western blot analysis . Positive_regulation CALCA CTGF 19307750 2086982 [Calcitonin] *induces* through ERK1/2 signaling in renal tubular cells . Positive_regulation CALCA IL1B 12836161 1107897 Mechanism of *induced* [calcitonin] gene related peptide production from dorsal root ganglion neurons of neonatal rats . Positive_regulation CALCA IL1B 17481780 1750505 JNK-AP-1 pathway involved in *induced* [calcitonin] gene related peptide secretion in human type II alveolar epithelial cells . Positive_regulation CALCA NEDD9 10455189 638618 [Calcitonin] *induces* the association of , paxillin , and focal adhesion kinase . Positive_regulation CALCB IL1B 15319367 1303746 In the present study , we demonstrated that human AEII A549 cells expressed [beta-CGRP] , and ( 0.001-50 ng/ml ) directly *increased* CGRP secretion from these cells in a time- and concentration dependent manner . Positive_regulation CALCB IL1B 17481780 1750515 deletion analysis identified an AP-1 consensus site at -643bp relative to the initiation site , which mediates the [beta-CGRP] gene transcription in *response* to . Positive_regulation CALCR ITGB2 22683637 2620984 Our further study revealed that exogenous Aft1p upregulates CTR2 transcription only in the presence of Mac1p , whereas exogenous *upregulates* [CTR2] transcription only in the presence of Aft1p . Positive_regulation CALCR ITGB2 22683637 2620985 Exogenous and Aft1p form a stable complex and synergistically *enhance* [CTR2] transcription . Positive_regulation CALCR ITGB2 9211922 441975 TGAGCAAA , appearing within the 5'-flanking region of the CTR1 promoter , is necessary and sufficient for the copper- and *dependent* [CTR1] transcriptional regulation . Positive_regulation CALD1 EPHB2 10712263 673970 Activation of , but not p38 MAP kinases , *results* in phosphorylation of [caldesmon] in vivo , which is a novel function for M ( 2 ) receptor activation in smooth muscle . Positive_regulation CALD1 EPHB2 12788788 1097199 Thrombin induced *dependent* [caldesmon] phosphorylation ( Ser789 ) was inhibited by either KN-93 , a specific CaM kinase II inhibitor , or U0126 , an inhibitor of MEK activation . Positive_regulation CALD1 EPHB2 15072969 1232647 PDBu produced time dependent increases in phosphorylation of p42 and p44 ERK and *dependent* phosphorylation of [caldesmon] at Ser789 in the uterine artery . Positive_regulation CALM3 ANGPT1 23041942 2726884 also *increased* Orai1 and [calmodulin] expression in mouse hearts in vivo . Positive_regulation CALM3 CABP4 2169075 140406 The activity of this phosphodiesterase is not *stimulated* by the , [calmodulin] . Positive_regulation CALM3 CABP4 6163856 14729 Both the initial rate of Ca2+ transport and the ( Ca2+ + Mg2+ ) -adenosine triphosphatase activity were *increased* approximately twofold by the , [calmodulin] . Positive_regulation CALM3 CAPN8 8515266 222057 Phosphorylation modulates *mediated* proteolysis and [calmodulin] binding of the 200-kDa and 160-kDa neurofilament proteins . Positive_regulation CALM3 CDKN1C 2952648 71174 It is proposed that P-57 binds and localizes calmodulin at specific sites within the cell and that free [calmodulin] is released locally in *response* to phosphorylation of by protein kinase C and/or to increases in intracellular free Ca2+ . Positive_regulation CALM3 EDN2 1326288 195644 The corresponding loss of cytosolic PKC , but not of CaM-PK , suggests a translocation of PKC and an *activation* of [CaM-PK] by . Positive_regulation CALM3 EPHB2 10349837 616972 Thus , TGFbeta1 affects *dependent* cell proliferation and ERK independent [N-CAM] expression in B104 cells . Positive_regulation CALM3 EPHB2 17268170 1765567 [Calcium-calmodulin] mediates house dust mite *induced* activation and IL-8 production in human respiratory epithelial cells . Positive_regulation CALM3 EPHB2 21671256 2460058 When PCP4 expression was induced with doxcycline , neurite outgrowth was significantly advanced in the presence of nerve growth factor (NGF) and dibutyryl cAMP , which was inhibited by W-7 , a [calmodulin] *inhibitor* , and PD98059 , an inhibitor . Positive_regulation CALM3 FAS 14578204 1156665 Although a broad-range caspase inhibitor partially blocked CaM antagonist mediated apoptosis , the neutralizing Fas antibody had no effect , suggesting that [CaM] antagonist mediated apoptosis does not *require* interaction between CaM antagonists and surface . Positive_regulation CALM3 FAS 18820240 2000782 In contrast , the mutant with the deletion of the 15 amino acid at the C-terminus *increased* its binding to [CaM] . Positive_regulation CALM3 FAS 23760276 2820159 NMR and surface plasmon resonance data show that three CaM antagonists ( N- ( 6-aminohexyl ) -5-chloro-1-naphthalene sulfonamide , tamoxifen , and trifluoperazine ) greatly *inhibit* [Fas-CaM] interactions by blocking the binding site on CaM . Positive_regulation CALM3 GPR115 15499021 1325624 dependent activation of protein kinase A (PKA) led to phosphorylation of RCS at Ser55 and *increased* its binding to [CaM] . Positive_regulation CALM3 GPR115 15845548 1418524 Thus , our results demonstrate that activation *induces* rapid FAK phosphorylation at Ser-843 through Ca2+ , [calmodulin] , and CaMKII . Positive_regulation CALM3 GPR132 15499021 1325613 dependent activation of protein kinase A (PKA) led to phosphorylation of RCS at Ser55 and *increased* its binding to [CaM] . Positive_regulation CALM3 GPR132 15845548 1418513 Thus , our results demonstrate that activation *induces* rapid FAK phosphorylation at Ser-843 through Ca2+ , [calmodulin] , and CaMKII . Positive_regulation CALM3 GPR87 15499021 1325693 dependent activation of protein kinase A (PKA) led to phosphorylation of RCS at Ser55 and *increased* its binding to [CaM] . Positive_regulation CALM3 GPR87 15845548 1418593 Thus , our results demonstrate that activation *induces* rapid FAK phosphorylation at Ser-843 through Ca2+ , [calmodulin] , and CaMKII . Positive_regulation CALM3 IL1B 12127053 966085 stimulation *had* no effect on endothelial [CAM] expression . Positive_regulation CALM3 IL1B 12412198 1010940 decreased the accumulation of aggrecan , hyaluronan and type II collagen in the CAM and increased intracellular MMP-1 , -3 and -13 at a concentration of 100 pg/ml. Xylosan polysulphate and chrondroitin polysulphate *restored* the expression of these [CAM] molecules in these IL-1 beta treated cultures . Positive_regulation CALM3 IL1B 9106260 424457 Since adhesion molecules ( AM ) induced on endothelial cells ( EC ) play an important role in T-cell migration into the CNS , the objective of this study was to examine the effect of IFN beta-1b on the expression of the AM , ICAM-1 , [V-CAM] and E-selection *induced* on EC by IFN-gamma , TNF-alpha , or . Positive_regulation CALM3 MAP2K6 12788788 1097205 Thrombin induced ERK dependent caldesmon phosphorylation ( Ser789 ) was inhibited by either KN-93 , a specific [CaM] kinase II *inhibitor* , or U0126 , an inhibitor of activation . Positive_regulation CALM3 TNF 10072259 594427 Similarly , the inhibition of EC protein kinase C ( PKC ) and tyrosine kinase ( TK ) pathways modulates *mediated* effects on [CAM] expression . Positive_regulation CALM3 TNF 16504556 1597844 The *induced* expression of [CAM] was exclusively dependent on the transcription factor NFkappaB since the inhibitor of NFkappaB activation , BAY 11-7082 , completely blocked the induction . Positive_regulation CALM3 TNF 18319592 1919500 Stimulation with significantly *increased* the expression of [CAM] , independently of the drugs used . Positive_regulation CALM3 TNF 18319592 1919501 None of the mTOR inhibitors influenced the *induced* expression of [CAM] , whereas adhesion of PBMC increased significantly , as described by other papers . Positive_regulation CALM3 TNF 22280832 2564970 Finally , ohioensin F inhibited *induced* [CAM] mRNA expression and NK-?B translocation . Positive_regulation CALM3 TNF 23724832 2833989 stimulation *increased* [CAM] and sCAM expression in a dose dependent and time dependent manner . Positive_regulation CALM3 TNF 24316968 2894855 It was demonstrated that carnosol inhibited *induced* [CAM] and chemokine expression in HUVECs . Positive_regulation CALM3 TNF 7514105 253919 One aspect of these interactions is the capacity of AM-derived to *induce* the expression of [cellular adhesion molecules (CAM)] on the surface of endothelial cells . Positive_regulation CALM3 TNF 8554699 337179 Vascular [CAM-1] *induced* expression was not altered . Positive_regulation CALM3 TNF 9022083 413247 This differential modulation of *induced* [CAM] expression by t-RA was reflected at steady state mRNA levels and in nuclear run-on studies . Positive_regulation CALM3 TNF 9106260 424455 Since adhesion molecules ( AM ) induced on endothelial cells ( EC ) play an important role in T-cell migration into the CNS , the objective of this study was to examine the effect of IFN beta-1b on the expression of the AM , ICAM-1 , [V-CAM] and E-selection *induced* on EC by IFN-gamma , , or IL-1 beta . Positive_regulation CALM3 TNF 9285482 451896 Both and UV light rapidly *stimulated* Ca2+ independent activity of [CaM-KII] in the monocytic leukemia , U937 . Positive_regulation CALM3 TNF 9832331 551717 Dissimilar levels of basal and *induced* [CAM] expression in vascular cells may explain the varied predisposition of different blood vessels to developing certain vasculopathies . Positive_regulation CALML3 CAPN8 19661453 2157782 We hypothesized that [CLP] *induces* diaphragm caspase-3 and activation , and that these two enzymes act at the level of the contractile proteins to reduce muscle force generation . Positive_regulation CALML3 TNF 24456467 2907470 LPS- and *induced* lethal shock , and [cecal ligation and puncture (CLP)] were performed in genetically or pharmacologically targeted mice . Positive_regulation CALR TNF 10360628 619675 The results demonstrate that the expression of both [cC1qR] and gC1qR by bone marrow vascular endothelial cells is *up-regulated* by inflammatory mediators , interferon-gamma , , and lipopolysaccharide ( Escherichia coli , 055 : B5 ) in a dose- and time dependent manner , as detected by enzyme linked immunosorbent assay . Positive_regulation CALR TNFSF10 17953526 1814628 The interaction with [calreticulin] *required* a conformational change in CD40L , and FasL and showed the same characteristics as calreticulin 's interaction with C1q and MBL : a time dependent saturable binding to immobilized protein , which was initially sensitive to salt but gradually developed into a salt-insensitive interaction . Positive_regulation CAMK1 CCND1 16603604 1568749 In fact , H2O2 stimulated [CaMK] activity , CaMK inhibitors prevented H2O2 induced cyclin D1 down-modulation , and CaMK overexpression *induced* degradation . Positive_regulation CAMK1 EPHB2 11682454 874018 PKC- and dependent activation of I kappa B kinase by lipopolysaccharide in macrophages : enhancement by P2Y receptor *mediated* [CaMK] activation . Positive_regulation CAMK1 EPHB2 15150258 1252317 These data are the first to suggest that activation and neurite outgrowth in response to depolarization are *mediated* by CaMKK activation of [CaMKI] . Positive_regulation CAMK4 CCND1 16603604 1568750 In fact , H2O2 stimulated [CaMK] activity , CaMK inhibitors prevented H2O2 induced cyclin D1 down-modulation , and CaMK overexpression *induced* degradation . Positive_regulation CAMK4 EPHB2 11682454 874019 PKC- and dependent activation of I kappa B kinase by lipopolysaccharide in macrophages : enhancement by P2Y receptor *mediated* [CaMK] activation . Positive_regulation CAMKK1 EPHB2 15150258 1252319 These data are the first to suggest that activation and neurite outgrowth in response to depolarization are *mediated* by [CaMKK] activation of CaMKI . Positive_regulation CAMKK2 EPHB2 15150258 1252321 These data are the first to suggest that activation and neurite outgrowth in response to depolarization are *mediated* by [CaMKK] activation of CaMKI . Positive_regulation CAMP EPHB2 15261456 1274486 Furthermore , inhibition of *blocked* HDAC inhibitor induced [LL-37] expression in colonic and gastric cells . Positive_regulation CAMP MAP2K6 15261456 1274492 Furthermore , inhibition of *blocked* HDAC inhibitor induced [LL-37] expression in colonic and gastric cells . Positive_regulation CAMP MUC16 18456648 1932955 Decreased [LL-37] and WLBU2 antibacterial activity was observed in the *presence* of or dialysed human saliva , whereas CSA-13 antibacterial activity was significantly resistant to inhibition by mucins . Positive_regulation CAMP TNF 23499548 2771994 siRNAs targeting CCAAT/enhancer binding protein-a ( C/EBPa ) suppressed visfatin induced and visfatin plus *induced* [CAMP] production . Positive_regulation CANX EPHB2 15757502 1409729 This phosphorylation may be mediated by [p90RSK] ( 90 kDa ribosomal protein S6K ) , which is *activated* by , and appears to involve phosphorylation at Ser1798 . Positive_regulation CAPN1 CST6 7680026 211373 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN1 EPHB2 18443189 1926537 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN1 EPHB2 23408424 2764596 We unravel novel mechanisms for activity- and *dependent* [calpain] action on gephyrin , which are likely relevant in the context of cellular signaling affecting GABAergic transmission and homeostatic synaptic plasticity in pathology . Positive_regulation CAPN1 ITGB2 16002691 1430994 Experiments performed with specific inhibitors revealed that entry of HIV-1 in activated CD4 ( + ) T cells is regulated by *dependent* ZAP70 , phospholipase Cgamma1 , and [calpain] enzymatic activities . Positive_regulation CAPN1 MAP2K6 10644690 661237 EGF induced rapid activation of calpain that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway , and [calpain] was *stimulated* by transfection of constitutively active . Positive_regulation CAPN1 MAP2K6 18443189 1926546 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN1 MMP28 17192848 1701876 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN1 MMP7 17192848 1701891 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN1 TNF 11281557 798918 Cytoprotective effect of prednisolone in hepatic IR injury was closely associated with suppression of production and [calpain] mu *activation* . Positive_regulation CAPN1 TNF 11288141 800382 Results of this study suggest may *induce* caspase-3 activation but not [calpain] activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation CAPN1 TNF 16574073 1543484 Tumor necrosis factor ( ) stimulation *induced* increased expression of [mu-calpain] , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation CAPN10 CST6 7680026 211383 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN10 EPHB2 18443189 1926553 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN10 EPHB2 23408424 2764597 We unravel novel mechanisms for activity- and *dependent* [calpain] action on gephyrin , which are likely relevant in the context of cellular signaling affecting GABAergic transmission and homeostatic synaptic plasticity in pathology . Positive_regulation CAPN10 ITGB2 16002691 1430995 Experiments performed with specific inhibitors revealed that entry of HIV-1 in activated CD4 ( + ) T cells is regulated by *dependent* ZAP70 , phospholipase Cgamma1 , and [calpain] enzymatic activities . Positive_regulation CAPN10 MAP2K6 10644690 661245 EGF induced rapid activation of calpain that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway , and [calpain] was *stimulated* by transfection of constitutively active . Positive_regulation CAPN10 MAP2K6 18443189 1926562 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN10 MMP28 17192848 1701898 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN10 MMP7 17192848 1701913 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN10 TNF 11281557 798919 Cytoprotective effect of prednisolone in hepatic IR injury was closely associated with suppression of production and [calpain] mu *activation* . Positive_regulation CAPN10 TNF 11288141 800383 Results of this study suggest may *induce* caspase-3 activation but not [calpain] activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation CAPN10 TNF 16574073 1543485 Tumor necrosis factor ( ) stimulation *induced* increased expression of [mu-calpain] , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation CAPN11 CST6 7680026 211393 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN11 EPHB2 18443189 1926569 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN11 EPHB2 23408424 2764598 We unravel novel mechanisms for activity- and *dependent* [calpain] action on gephyrin , which are likely relevant in the context of cellular signaling affecting GABAergic transmission and homeostatic synaptic plasticity in pathology . Positive_regulation CAPN11 ITGB2 16002691 1430996 Experiments performed with specific inhibitors revealed that entry of HIV-1 in activated CD4 ( + ) T cells is regulated by *dependent* ZAP70 , phospholipase Cgamma1 , and [calpain] enzymatic activities . Positive_regulation CAPN11 MAP2K6 10644690 661253 EGF induced rapid activation of calpain that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway , and [calpain] was *stimulated* by transfection of constitutively active . Positive_regulation CAPN11 MAP2K6 18443189 1926578 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN11 MMP28 17192848 1701920 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN11 MMP7 17192848 1701935 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN11 TNF 11281557 798920 Cytoprotective effect of prednisolone in hepatic IR injury was closely associated with suppression of production and [calpain] mu *activation* . Positive_regulation CAPN11 TNF 11288141 800384 Results of this study suggest may *induce* caspase-3 activation but not [calpain] activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation CAPN11 TNF 16574073 1543486 ( TNF-alpha ) stimulation *induced* increased expression of [mu-calpain] , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation CAPN12 CST6 7680026 211363 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN12 EPHB2 18443189 1926521 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN12 EPHB2 23408424 2764595 We unravel novel mechanisms for activity- and *dependent* [calpain] action on gephyrin , which are likely relevant in the context of cellular signaling affecting GABAergic transmission and homeostatic synaptic plasticity in pathology . Positive_regulation CAPN12 ITGB2 16002691 1430993 Experiments performed with specific inhibitors revealed that entry of HIV-1 in activated CD4 ( + ) T cells is regulated by *dependent* ZAP70 , phospholipase Cgamma1 , and [calpain] enzymatic activities . Positive_regulation CAPN12 MAP2K6 10644690 661229 EGF induced rapid activation of calpain that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway , and [calpain] was *stimulated* by transfection of constitutively active . Positive_regulation CAPN12 MAP2K6 18443189 1926530 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN12 MMP28 17192848 1701854 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN12 MMP7 17192848 1701869 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN12 TNF 11281557 798917 Cytoprotective effect of prednisolone in hepatic IR injury was closely associated with suppression of production and [calpain] mu *activation* . Positive_regulation CAPN12 TNF 11288141 800381 Results of this study suggest may *induce* caspase-3 activation but not [calpain] activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation CAPN12 TNF 16574073 1543483 ( TNF-alpha ) stimulation *induced* increased expression of [mu-calpain] , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation CAPN13 CST6 7680026 211473 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN13 EPHB2 18443189 1926697 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN13 EPHB2 23408424 2764606 We unravel novel mechanisms for activity- and *dependent* [calpain] action on gephyrin , which are likely relevant in the context of cellular signaling affecting GABAergic transmission and homeostatic synaptic plasticity in pathology . Positive_regulation CAPN13 ITGB2 16002691 1431004 Experiments performed with specific inhibitors revealed that entry of HIV-1 in activated CD4 ( + ) T cells is regulated by *dependent* ZAP70 , phospholipase Cgamma1 , and [calpain] enzymatic activities . Positive_regulation CAPN13 MAP2K6 10644690 661317 EGF induced rapid activation of [calpain] that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway , and calpain was *stimulated* by transfection of constitutively active . Positive_regulation CAPN13 MAP2K6 18443189 1926706 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN13 MMP28 17192848 1702096 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN13 MMP7 17192848 1702111 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN13 TNF 11281557 798928 Cytoprotective effect of prednisolone in hepatic IR injury was closely associated with suppression of production and [calpain] mu *activation* . Positive_regulation CAPN13 TNF 11288141 800393 Results of this study suggest may *induce* caspase-3 activation but not [calpain] activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation CAPN13 TNF 16574073 1543494 Tumor necrosis factor ( ) stimulation *induced* increased expression of [mu-calpain] , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation CAPN14 CST6 7680026 211483 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN14 EPHB2 18443189 1926713 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN14 EPHB2 23408424 2764607 We unravel novel mechanisms for activity- and *dependent* [calpain] action on gephyrin , which are likely relevant in the context of cellular signaling affecting GABAergic transmission and homeostatic synaptic plasticity in pathology . Positive_regulation CAPN14 ITGB2 16002691 1431005 Experiments performed with specific inhibitors revealed that entry of HIV-1 in activated CD4 ( + ) T cells is regulated by *dependent* ZAP70 , phospholipase Cgamma1 , and [calpain] enzymatic activities . Positive_regulation CAPN14 MAP2K6 10644690 661325 EGF induced rapid activation of calpain that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway , and [calpain] was *stimulated* by transfection of constitutively active . Positive_regulation CAPN14 MAP2K6 18443189 1926722 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN14 MMP28 17192848 1702118 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN14 MMP7 17192848 1702133 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN14 TNF 11281557 798929 Cytoprotective effect of prednisolone in hepatic IR injury was closely associated with suppression of production and [calpain] mu *activation* . Positive_regulation CAPN14 TNF 11288141 800394 Results of this study suggest may *induce* caspase-3 activation but not [calpain] activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation CAPN14 TNF 16574073 1543495 ( TNF-alpha ) stimulation *induced* increased expression of [mu-calpain] , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation CAPN15 CST6 7680026 211353 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN15 EPHB2 18443189 1926505 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN15 EPHB2 23408424 2764594 We unravel novel mechanisms for activity- and *dependent* [calpain] action on gephyrin , which are likely relevant in the context of cellular signaling affecting GABAergic transmission and homeostatic synaptic plasticity in pathology . Positive_regulation CAPN15 ITGB2 16002691 1430991 Experiments performed with specific inhibitors revealed that entry of HIV-1 in activated CD4 ( + ) T cells is regulated by *dependent* ZAP70 , phospholipase Cgamma1 , and [calpain] enzymatic activities . Positive_regulation CAPN15 MAP2K6 10644690 661221 EGF induced rapid activation of calpain that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway , and [calpain] was *stimulated* by transfection of constitutively active . Positive_regulation CAPN15 MAP2K6 18443189 1926514 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN15 MMP28 17192848 1701832 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN15 MMP7 17192848 1701847 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN15 TNF 11281557 798916 Cytoprotective effect of prednisolone in hepatic IR injury was closely associated with suppression of production and [calpain] mu *activation* . Positive_regulation CAPN15 TNF 11288141 800365 Results of this study suggest may *induce* caspase-3 activation but not [calpain] activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation CAPN15 TNF 16574073 1543467 ( TNF-alpha ) stimulation *induced* increased expression of [mu-calpain] , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation CAPN2 CAPN8 15955824 1440683 We found that activity increased in response to RANKL in both cell types based on alpha-spectrinolysis and that mu-calpain , rather than [m-calpain] , was *activated* during RANKL supported osteoclastogenesis in RAW 264.7 cells . Positive_regulation CAPN2 CAPN8 9925759 588347 When [m-calpain] activity and myoblast fusion were *prevented* by addition of inhibitors entering the cells , the amounts of desmin , talin , and fibronectin were increased , whereas the amount of vimentin was unchanged . Positive_regulation CAPN2 CST6 7680026 211403 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN2 EPHB2 11319218 827097 Membrane proximal signaling is *required* for [M-calpain] activation downstream of epidermal growth factor receptor signaling . Positive_regulation CAPN2 EPHB2 14993287 1216008 We now show that directly phosphorylates and *activates* [m-calpain] both in vitro and in vivo . Positive_regulation CAPN2 EPHB2 18443189 1926585 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN2 EPHB2 19946123 2190644 *regulates* [calpain 2-induced] androgen receptor proteolysis in CWR22 relapsed prostate tumor cell lines . Positive_regulation CAPN2 EPHB2 23408424 2764599 We unravel novel mechanisms for activity- and *dependent* [calpain] action on gephyrin , which are likely relevant in the context of cellular signaling affecting GABAergic transmission and homeostatic synaptic plasticity in pathology . Positive_regulation CAPN2 ITGB2 16002691 1430997 Experiments performed with specific inhibitors revealed that entry of HIV-1 in activated CD4 ( + ) T cells is regulated by *dependent* ZAP70 , phospholipase Cgamma1 , and [calpain] enzymatic activities . Positive_regulation CAPN2 MAP2K6 10644690 661261 EGF induced rapid activation of calpain that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway , and [calpain] was *stimulated* by transfection of constitutively active . Positive_regulation CAPN2 MAP2K6 18443189 1926594 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN2 MMP28 17192848 1701942 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN2 MMP7 17192848 1701957 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN2 TNF 11281557 798921 Cytoprotective effect of prednisolone in hepatic IR injury was closely associated with suppression of production and [calpain] mu *activation* . Positive_regulation CAPN2 TNF 11288141 800385 Results of this study suggest may *induce* caspase-3 activation but not [calpain] activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation CAPN2 TNF 15501405 1327058 Implication of prostaglandin E ( 2 ) in *induced* release of [m-calpain] from HCS-2/8 chondrocytes . Positive_regulation CAPN2 TNF 15501405 1327059 ( 10 ng/ml ) *stimulated* [m-calpain] release with transient increase in cellular m-calpain in HCS-2/8 cells . Positive_regulation CAPN2 TNF 15501405 1327060 AH6809 , an EP1/2 antagonist , but not SC19220 ( an EP1 antagonist ) , effectively inhibited *induced* [m-calpain] release . Positive_regulation CAPN2 TNF 15501405 1327061 These results suggest that *stimulates* upregulation and release of [m-calpain] in chondrocytic HCS-2/8 cells , and that stimulation of EP2-PGE ( 2 ) receptor by produced PGE ( 2 ) is deeply involved in this process . Positive_regulation CAPN2 TNF 16574073 1543487 ( TNF-alpha ) stimulation *induced* increased expression of [mu-calpain] , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation CAPN3 CST6 7680026 211413 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN3 EPHB2 18443189 1926601 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN3 EPHB2 23408424 2764600 We unravel novel mechanisms for activity- and *dependent* [calpain] action on gephyrin , which are likely relevant in the context of cellular signaling affecting GABAergic transmission and homeostatic synaptic plasticity in pathology . Positive_regulation CAPN3 ITGB2 16002691 1430998 Experiments performed with specific inhibitors revealed that entry of HIV-1 in activated CD4 ( + ) T cells is regulated by *dependent* ZAP70 , phospholipase Cgamma1 , and [calpain] enzymatic activities . Positive_regulation CAPN3 MAP2K6 10644690 661269 EGF induced rapid activation of calpain that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway , and [calpain] was *stimulated* by transfection of constitutively active . Positive_regulation CAPN3 MAP2K6 18443189 1926610 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN3 MMP28 17192848 1701964 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN3 MMP7 17192848 1701979 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN3 TNF 11281557 798922 Cytoprotective effect of prednisolone in hepatic IR injury was closely associated with suppression of production and [calpain] mu *activation* . Positive_regulation CAPN3 TNF 11288141 800386 Results of this study suggest may *induce* caspase-3 activation but not [calpain] activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation CAPN3 TNF 16574073 1543488 Tumor necrosis factor ( ) stimulation *induced* increased expression of [mu-calpain] , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation CAPN5 CST6 7680026 211423 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN5 EPHB2 18443189 1926617 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN5 EPHB2 23408424 2764601 We unravel novel mechanisms for activity- and *dependent* [calpain] action on gephyrin , which are likely relevant in the context of cellular signaling affecting GABAergic transmission and homeostatic synaptic plasticity in pathology . Positive_regulation CAPN5 ITGB2 16002691 1430999 Experiments performed with specific inhibitors revealed that entry of HIV-1 in activated CD4 ( + ) T cells is regulated by *dependent* ZAP70 , phospholipase Cgamma1 , and [calpain] enzymatic activities . Positive_regulation CAPN5 MAP2K6 10644690 661277 EGF induced rapid activation of calpain that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway , and [calpain] was *stimulated* by transfection of constitutively active . Positive_regulation CAPN5 MAP2K6 18443189 1926626 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN5 MMP28 17192848 1701986 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN5 MMP7 17192848 1702001 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN5 TNF 11281557 798923 Cytoprotective effect of prednisolone in hepatic IR injury was closely associated with suppression of production and [calpain] mu *activation* . Positive_regulation CAPN5 TNF 11288141 800387 Results of this study suggest may *induce* caspase-3 activation but not [calpain] activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation CAPN5 TNF 16574073 1543489 ( TNF-alpha ) stimulation *induced* increased expression of [mu-calpain] , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation CAPN6 CST6 7680026 211433 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN6 EPHB2 18443189 1926633 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN6 EPHB2 23408424 2764602 We unravel novel mechanisms for activity- and *dependent* [calpain] action on gephyrin , which are likely relevant in the context of cellular signaling affecting GABAergic transmission and homeostatic synaptic plasticity in pathology . Positive_regulation CAPN6 ITGB2 16002691 1431000 Experiments performed with specific inhibitors revealed that entry of HIV-1 in activated CD4 ( + ) T cells is regulated by *dependent* ZAP70 , phospholipase Cgamma1 , and [calpain] enzymatic activities . Positive_regulation CAPN6 MAP2K6 10644690 661285 EGF induced rapid activation of calpain that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway , and [calpain] was *stimulated* by transfection of constitutively active . Positive_regulation CAPN6 MAP2K6 18443189 1926642 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN6 MMP28 17192848 1702008 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN6 MMP7 17192848 1702023 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN6 TNF 11281557 798924 Cytoprotective effect of prednisolone in hepatic IR injury was closely associated with suppression of production and [calpain] mu *activation* . Positive_regulation CAPN6 TNF 11288141 800388 Results of this study suggest may *induce* caspase-3 activation but not [calpain] activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation CAPN6 TNF 16574073 1543490 Tumor necrosis factor ( ) stimulation *induced* increased expression of [mu-calpain] , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation CAPN7 CST6 7680026 211443 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN7 EPHB2 18443189 1926649 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN7 EPHB2 23408424 2764603 We unravel novel mechanisms for activity- and *dependent* [calpain] action on gephyrin , which are likely relevant in the context of cellular signaling affecting GABAergic transmission and homeostatic synaptic plasticity in pathology . Positive_regulation CAPN7 ITGB2 16002691 1431001 Experiments performed with specific inhibitors revealed that entry of HIV-1 in activated CD4 ( + ) T cells is regulated by *dependent* ZAP70 , phospholipase Cgamma1 , and [calpain] enzymatic activities . Positive_regulation CAPN7 MAP2K6 10644690 661293 EGF induced rapid activation of calpain that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway , and [calpain] was *stimulated* by transfection of constitutively active . Positive_regulation CAPN7 MAP2K6 18443189 1926658 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN7 MMP28 17192848 1702030 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN7 MMP7 17192848 1702045 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN7 TNF 11281557 798925 Cytoprotective effect of prednisolone in hepatic IR injury was closely associated with suppression of production and [calpain] mu *activation* . Positive_regulation CAPN7 TNF 11288141 800389 Results of this study suggest may *induce* caspase-3 activation but not [calpain] activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation CAPN7 TNF 16574073 1543491 ( TNF-alpha ) stimulation *induced* increased expression of [mu-calpain] , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation CAPN8 A2M 2422211 58127 Purified alpha-cysteine protease inhibitor , , as well as purified heavy chain of HMWK or HMWK itself *inhibited* purified platelet [calpain] . Positive_regulation CAPN8 ABCD1 23266505 2737440 *increased* [calpain] expression and caspase-3 activity and promoted Bid cleavage . Positive_regulation CAPN8 ABCD1 23266505 2737469 Furthermore , treatment with spironoclactone not only attenuated the pro-apoptotic effect of ALD but reversed the *induced* increase of [calpain] and AIF levels . Positive_regulation CAPN8 ABCD1 24551180 2915531 stimulation *increased* cardiomyocytes apoptosis , caspase-3 activity and protein expression of [calpain] , tBid and AIF in the cytosol ( p < 0.05 ) . Positive_regulation CAPN8 ACP2 10694431 671320 The protease responsible appears to be calcium dependent and the concomitant cleavage of PARP and p53 was consistent with a *mediated* activation of [calpain] . Positive_regulation CAPN8 ACSM3 12184858 978149 Several studies have implicated [calpain] *activation* following . Positive_regulation CAPN8 AHSG 17942392 1830582 Consistent with the yeast two-hybrid studies , neither *stabilized* [mu-calpain] nor prevented its aggregation . Positive_regulation CAPN8 AKT1 18443189 1926666 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of MEK/ERK , p38 , JNK , , and Rac . Positive_regulation CAPN8 AKT1 23071514 2685897 Pro-death activity of violacein is actually carried out by inhibition of [calpain] and DAPK1 and *activation* of PKA , and PDK , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation CAPN8 AKT2 18443189 1926667 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of MEK/ERK , p38 , JNK , , and Rac . Positive_regulation CAPN8 AKT2 23071514 2685898 Pro-death activity of violacein is actually carried out by inhibition of [calpain] and DAPK1 and *activation* of PKA , and PDK , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation CAPN8 AKT3 18443189 1926668 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of MEK/ERK , p38 , JNK , , and Rac . Positive_regulation CAPN8 AKT3 23071514 2685899 Pro-death activity of violacein is actually carried out by inhibition of [calpain] and DAPK1 and *activation* of PKA , and PDK , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation CAPN8 ANGPT2 15723976 1376808 Stimulation of rat cardiomyocytes with *increased* [calpain] activity significantly ( 433+/-11 % ; Positive_regulation CAPN8 ANGPT2 15723976 1376822 stimulation of cardiomyocytes *increased* [calpain] activity , leading to proteolysis of the autoinhibitory domain of CnA . Positive_regulation CAPN8 ANGPT2 18258859 1884907 In vitro experiments using vascular smooth muscle cells showed that calpastatin transgene expression blunted [calpain] *activation* by through epidermal growth factor receptor transactivation . Positive_regulation CAPN8 ANK1 16566909 1549930 Intracellular Na+ concentration ( [ Na+ ] i ) measured using 23Na-magnetic resonance spectroscopy , Na+/K+-ATPase activity , detachment of Na+/K+-ATPase alpha subunits from the membrane cytoskeleton , degradation of fodrin and , and [calpain] *activation* were analysed in isolated rat hearts reperfused after 60 min of ischemia with or without previous IPC and different treatments aimed to mimic or blunt the effects of IPC . Positive_regulation CAPN8 ANK2 16566909 1549931 Intracellular Na+ concentration ( [ Na+ ] i ) measured using 23Na-magnetic resonance spectroscopy , Na+/K+-ATPase activity , detachment of Na+/K+-ATPase alpha subunits from the membrane cytoskeleton , degradation of fodrin and , and [calpain] *activation* were analysed in isolated rat hearts reperfused after 60 min of ischemia with or without previous IPC and different treatments aimed to mimic or blunt the effects of IPC . Positive_regulation CAPN8 ANK3 16566909 1549932 Intracellular Na+ concentration ( [ Na+ ] i ) measured using 23Na-magnetic resonance spectroscopy , Na+/K+-ATPase activity , detachment of Na+/K+-ATPase alpha subunits from the membrane cytoskeleton , degradation of fodrin and , and [calpain] *activation* were analysed in isolated rat hearts reperfused after 60 min of ischemia with or without previous IPC and different treatments aimed to mimic or blunt the effects of IPC . Positive_regulation CAPN8 APOB 18624772 2179393 *Activation* of protease [calpain] by oxidized and glycated increases the degradation of endothelial nitric oxide synthase . Positive_regulation CAPN8 ARID4B 17986223 1850594 Interestingly , did not *induce* caspase and [calpain] activation , suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways . Positive_regulation CAPN8 ATP5O 2145987 143997 Whereas the extent of [calpain] *activation* of erythrocyte membrane Ca2 ( + ) -pumping of normal subjects was almost equal to that due to calmodulin , calpain activation of the HTN and SCA pump was greater than activation by calmodulin . Positive_regulation CAPN8 ATP5O 2825780 80998 *Activation* of erythrocyte membrane by [calpain] . Positive_regulation CAPN8 ATP5O 2829740 84879 We now demonstrate a similar kind of *activation* of the human erythrocyte membrane by [calpain] ( calcium dependent neutral protease ) isolated from the human red cell cytosol . Positive_regulation CAPN8 BAX 19894226 2188697 Other events in apoptosis included overexpression of , loss of DeltaPsi ( m ) , mitochondrial release of cytochrome c and Smac into the cytosol , down-regulation of baculoviral inhibitor-of-apoptosis repeat containing proteins , and *activation* of [calpain] , caspase-9 , and caspase-3 . Positive_regulation CAPN8 BCL2 9044846 413895 Both gadd153 mRNA level increase and internucleosomal DNA fragmentation were inhibited by N-tosyl-L-phenylalanine chloromethylketone , a serine threonine protease inhibitor , N-acetyl-leucyl-leucyl-norleucinal , an *inhibitor* of [calpain] , N-acetylcysteine , an inhibitor of oxidative metabolism , and overexpression of . Positive_regulation CAPN8 BDNF 20089917 2201545 *stimulated* m-calpain but not [mu-calpain] serine phosphorylation , an effect also blocked by MAPK inhibitors . Positive_regulation CAPN8 BDNF 23467348 2749974 also *activates* [calpain] , a calcium dependent cysteine protease , which has been shown to play a critical role in learning and memory . Positive_regulation CAPN8 BECN1 19778902 2202891 We also found that ras activates a GTPase RhoA , that RhoA *promotes* activation of a protease [calpain] , and that calpain triggers degradation of , a critical mediator of autophagy , in these cells . Positive_regulation CAPN8 CA2 10217261 608357 Conversely , excess elicited necrosis and *activated* [calpain] but not caspase-3 . Positive_regulation CAPN8 CA2 10384098 624715 Two lines of evidence indicate that the *dependent* cysteine protease [calpain] plays a major role in initiating ZAP-70 degradation : 1 ) treatment of T cells with cell permeating inhibitors of calpain markedly reduces ZAP-70 degradation ; Positive_regulation CAPN8 CA2 10395949 627663 AAT degradation was also prevented by [calpain] *inhibitors* ( dependent protease inhibitor ) such as calpeptin at 1 nM , 10 nM , 0.1 microM , 1 microM and 10 microM , and by calpain inhibitor peptide , but not by other protease inhibitors ( 10 microM leupeptin , pepstatin , chymostatin ) . Positive_regulation CAPN8 CA2 11104058 756404 This leakage may reflect degradation of membrane proteins by the *activated* neutral protease [calpain] . Positive_regulation CAPN8 CA2 12173413 974461 Placenta [mu-calpain] requires 50-70 microM Ca2+ and placenta m-calpain *requires* 450-460 microM for half-maximal proteolytic activity . Positive_regulation CAPN8 CA2 12951515 1137376 When expressed in COS7 cells , hnRNP K and [micro-calpain] co-localized in the cytosol , and stimulation of the cells *resulted* in proteolysis of hnRNP K , indicating that hnRNP K is an in vivo substrate for calpain . Positive_regulation CAPN8 CA2 1365908 209482 It seems likely that [calpain] activity is *regulated* by binding of to specific sites on the calpain molecule , with binding to each site eliciting a response ( proteolytic activity , calpastatin binding , etc. ) specific for that site . Positive_regulation CAPN8 CA2 14686903 1179466 However , inhibition of the glutamate activated *dependent* protease [calpain] by calpeptin completely blocked IkappaBalpha degradation and reduced the nuclear translocation of p65 . Positive_regulation CAPN8 CA2 14686903 1179494 Our data indicate that the *dependent* protease [calpain] is involved in the NF-kappaB activation in neurons in response to N-methyl-d-aspartate receptor occupancy by glutamate . Positive_regulation CAPN8 CA2 14977601 1213277 a slowly developing moderate increase of *activated* PKC-alpha and [calpain] , promoting internalization of Na+ channels , whereas an immediate monophasic and salient plateau increase of Ca2+ lowered alpha- and beta1-subunit mRNA levels . Positive_regulation CAPN8 CA2 15476820 1319583 *Activation* of [calpain] by : roles of the large subunit N-terminal and domain III-IV linker peptides . Positive_regulation CAPN8 CA2 15569003 1409514 Multiple interactions of the ` transducer ' govern its function in [calpain] *activation* by . Positive_regulation CAPN8 CA2 15952172 1427823 From these findings , we conclude that increases in *induced* [calpain] activity may play a crucial role in neurodegeneration in acute EAE . Positive_regulation CAPN8 CA2 15987693 1446736 These results suggest that *stimulated* [calpain] activity and CHOP expression play important roles in celecoxib induced apoptosis in gastric mucosal cells . Positive_regulation CAPN8 CA2 16107503 1498886 Biochemical assays suggest that [mu-calpain] becomes proteolytically active in the *presence* of 2-200 microM . Positive_regulation CAPN8 CA2 16149054 1467292 In this process , *dependent* mitochondrial nitric oxide synthase ( mtNOS ) and [calpain] are induced which lead to cytoskeletal de-arrangement and cellular remodeling . Positive_regulation CAPN8 CA2 17191858 1358576 Since the peptide-biphenyl hybrids reported in the present paper do not possess a reactive electrophilic functionality , we hypothesize that they interfere with the *activation* of [calpain] by , and present experimental and computational results on the binding of peptide-biphenyl hybrids to Ca2+ . Positive_regulation CAPN8 CA2 17323976 1711838 The increased subsequently *mediated* [calpain] activation and intracellular ROS production . Positive_regulation CAPN8 CA2 1734892 181718 A leupeptin analogue , Cbz-Leu-Leu-Leu-aldehyde ( ZLLLal ) , inhibits both the autolytic activation of [mu-calpain] and fusion *induced* by A2C and . Positive_regulation CAPN8 CA2 18268335 1871930 A small molecule ( S107 ) that prevents depletion of calstabin1 from the RyR1 complex improved force generation and exercise capacity , reduced *dependent* neutral protease [calpain] activity and plasma creatine kinase levels . Positive_regulation CAPN8 CA2 18718443 1968301 Oxidants and *induce* PGC-1alpha degradation through [calpain] . Positive_regulation CAPN8 CA2 18806756 1987350 An increase in intracellular is *required* for the activation of mitochondrial [calpain] to release AIF during cell death . Positive_regulation CAPN8 CA2 2015293 156757 The four proteolytically active forms of calpain are : ( 1 ) autolyzed [mu-calpain] , having polypeptide subunits of 76 and 18 kDa and *requiring* 0.60 microM for half-maximal activity ; Positive_regulation CAPN8 CA2 2016996 156979 Hammersten casein , the commonly used substrate for measuring mu- and m-calpain activity , *required* 2.5 microM for half-maximal activity of [mu-calpain] and 290 microM Ca2+ for half-maximal activity of m-calpain . Positive_regulation CAPN8 CA2 2016996 157007 Rabbit skeletal muscle myofibrils and rabbit skeletal muscle troponin *required* 65 microM and 24 microM for half-maximal activity of [mu-calpain] and 380 microM and 580 microM Ca2+ for half-maximal activity of m-calpain , respectively . Positive_regulation CAPN8 CA2 2016996 157035 The three synthetic substrates tested , Suc-Leu-Tyr-MCA , Boc-Leu-Thr-Arg-MCA , and Suc-Leu-Leu-Val-Tyr-MCA , *required* 1.6 microM to 3.7 microM for half-maximal activity of [mu-calpain] and 200 to 560 microM Ca2+ for half-maximal activity of m-calpain . Positive_regulation CAPN8 CA2 2145987 143994 Whereas the extent of [calpain] *activation* of erythrocyte membrane ( + ) -pumping ATPase of normal subjects was almost equal to that due to calmodulin , calpain activation of the HTN and SCA pump was greater than activation by calmodulin . Positive_regulation CAPN8 CA2 22931549 2693143 PM also mediated intracellular calcium mobilization via the transient receptor potential cation channel M2 ( TRPM2 ) , in a ROS dependent manner with subsequent activation of the *dependent* protease [calpain] . Positive_regulation CAPN8 CA2 23250437 2708796 Here we demonstrate that *activation* of [calpain] , a Ca2+ dependent cysteine protease , by upregulation of AMPA receptors generates carboxy-terminal cleaved TDP-43 fragments and causes mislocalization of TDP-43 in the motor neurons expressing glutamine/arginine site unedited GluA2 of conditional ADAR2 knockout (AR2) mice that mimic the amyotrophic lateral sclerosis pathology . Positive_regulation CAPN8 CA2 2542320 112254 Bovine skeletal muscle [mu-calpain] *required* 40-50 microM for half-maximal rate of proteolysis of a casein substrate , 140-150 microM Ca2+ for half-maximal autolysis in the presence of 80 microM phosphatidylinositol , and 190-210 microM Ca2+ for half-maximal autolysis in the absence of phosphatidylinositol . Positive_regulation CAPN8 CA2 2548504 115797 Evidence for *induced* translocation of [calpain] to the cell membrane , followed by its autolytic activation , has been discussed . Positive_regulation CAPN8 CA2 2553696 120691 Unautolyzed [mu-calpain] , however , *required* slightly more for half-maximal binding to calpastatin than for half-maximal activity . Positive_regulation CAPN8 CA2 2825780 80997 *Activation* of erythrocyte membrane by [calpain] . Positive_regulation CAPN8 CA2 2829740 84878 We now demonstrate a similar kind of *activation* of the human erythrocyte membrane by [calpain] ( calcium dependent neutral protease ) isolated from the human red cell cytosol . Positive_regulation CAPN8 CA2 2851997 102453 The degradation of phosphorylated and dephosphorylated neurofilament proteins by the *activated* neutral proteinase [calpain] was studied . Positive_regulation CAPN8 CA2 2994060 50479 Our results suggest that the *mediated* proteolytic activity of [calpain] is controlled through the cooperative and/or sequential actions of multiple Ca2+ binding sites present in both two-subunit molecules , heavy and light subunits of calpain . Positive_regulation CAPN8 CA2 6095848 43056 Only in the *presence* of , calpastatin bound to [calpain-Sepharose] , but the interaction resulted in rather extensive fragmentation of a calpastatin molecule into several peptides of Mr 14000 to 70000 , which still retain inhibitory activities against calpain . Positive_regulation CAPN8 CA2 8058728 268141 Alkylation of erythrocyte thiols also promoted translocation of [calpain] to the membrane , especially in the *presence* of . Positive_regulation CAPN8 CA2 8547354 346383 Human [mu-calpain] is *activated* maximally by 100-200 microM . Positive_regulation CAPN8 CA2 9045698 416405 Accordingly , the GEF activity of CDC25 ( Mm ) was increased severalfold by the *dependent* protease [calpain] that cleaves around a PEST-like region ( residues 798-853 ) , producing C-terminal fragments of 43-56 kDa . Positive_regulation CAPN8 CA2 9166746 432406 The enhancement of fodrin breakdown was completely blocked by omission of extracellular Ca2+ and significantly inhibited by calpain inhibitors such as E-64 and calpain inhibitor-I , thereby suggesting that the fodrin breakdown induced by hypoxia/hypoglycemia is due to the activation of *stimulated* neutral protease [calpain] . Positive_regulation CAPN8 CA2 9207214 440728 Furthermore , the induced *activation* of [mu-calpain] and the processing of profilaggrin were affected by the addition of the synthetic calpastatin inhibitor . Positive_regulation CAPN8 CA2 9271093 446626 The results presented provide more information on the sequential mechanism that promotes the *induced* activation of human erythrocyte [mu-calpain] under physiological conditions . Positive_regulation CAPN8 CA2 9928631 559976 In the presence of 1 microM free Ca2+ , 10 pM free Pb2+ reduced calpain activity , but in the presence of 100 microM free , 1 nM free Pb2+ failed to *inhibit* [calpain] . Positive_regulation CAPN8 CALM3 8980652 403746 In order to demonstrate , unequivocally , that substrate recognition does not require an interaction between calpain and a substrate 's calmodulin binding domain , recombinant , full-length caldesmon and a mutant lacking the calmodulin binding domain were tested as substrates for [calpain] in the *presence* and absence of . Positive_regulation CAPN8 CALML3 19661453 2157795 We hypothesized that *induces* diaphragm caspase-3 and [calpain] activation , and that these two enzymes act at the level of the contractile proteins to reduce muscle force generation . Positive_regulation CAPN8 CALML3 19661453 2157871 significantly *increased* diaphragm [calpain] activity ( P < 0.02 ) , caspase-3 activity ( P < 0.02 ) , active calpain I protein levels ( P < 0.02 ) , and active caspase-3 protein ( P < 0.02 ) . Positive_regulation CAPN8 CAPN2 15713646 1373953 Molecular downregulation or RNA interference mediated depletion of mu-calpain ( calpain 1 ) but not ( calpain 2 ) *blocked* IP-9 induced [calpain] activation and motility . Positive_regulation CAPN8 CAPN2 19598167 2123737 Thus , our results indicate that the blockage of calpains suppresses p38 MAPK phosphorylation , and identifies [calpain] *activation* ( most likely ) as an early event in heat stress induced male germ cell apoptosis . Positive_regulation CAPN8 CAPNS1 12569370 1057294 Treatment of ZR75 cultures with calcium+A23187 recapitulated the formation of the calcium/calpain induced LMW forms of cyclin E. Altered calcium homeostasis and/or inability of the endogenous calpain inhibitor to control the activity of high levels of the may *contribute* to increased [calpain] activity in breast tumors , causing abundant levels of LMW cyclin E . Positive_regulation CAPN8 CAPNS1 19598167 2123738 Thus , our results indicate that the blockage of calpains suppresses p38 MAPK phosphorylation , and identifies [calpain] *activation* ( most likely ) as an early event in heat stress induced male germ cell apoptosis . Positive_regulation CAPN8 CAPNS2 12569370 1057295 Treatment of ZR75 cultures with calcium+A23187 recapitulated the formation of the calcium/calpain induced LMW forms of cyclin E. Altered calcium homeostasis and/or inability of the endogenous calpain inhibitor to control the activity of high levels of the may *contribute* to increased [calpain] activity in breast tumors , causing abundant levels of LMW cyclin E . Positive_regulation CAPN8 CASP1 11102478 756169 The lack of effect of the PS-1P264L mutation is confirmed by measures of basal- and toxin induced and [calpain] *activation* , biochemical indices of apoptotic and necrotic signaling , respectively . Positive_regulation CAPN8 CASP1 11413236 828621 Cleavage of Bax is mediated by *dependent* or -independent [calpain] activation in dopaminergic neuronal cells : protective role of Bcl-2 . Positive_regulation CAPN8 CASP1 12175527 974728 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Positive_regulation CAPN8 CASP1 12175527 975092 Taken together , the chemopreventive effects of Se-MSC may be related in part to the caspase-3 activation , the down-regulation of IAP family proteins , and Bax cleavage mediated by *dependent* [calpain] activation . Positive_regulation CAPN8 CASP1 12469198 1032432 Taken together , the apoptotic effects of NPPA may be related , in part to the caspase-3 activation , the down-regulation of XIAP , and Bax cleavage mediated by dependent [calpain] *activation* . Positive_regulation CAPN8 CASP1 20406947 2256106 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , *dependent* amplification of mitochondrial depolarization , activation of [calpain] , and Bax cleavage . Positive_regulation CAPN8 CASP10 11102478 756170 The lack of effect of the PS-1P264L mutation is confirmed by measures of basal- and toxin induced and [calpain] *activation* , biochemical indices of apoptotic and necrotic signaling , respectively . Positive_regulation CAPN8 CASP10 11413236 828622 Cleavage of Bax is mediated by dependent or -independent [calpain] *activation* in dopaminergic neuronal cells : protective role of Bcl-2 . Positive_regulation CAPN8 CASP10 12175527 974729 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Positive_regulation CAPN8 CASP10 12175527 975093 Taken together , the chemopreventive effects of Se-MSC may be related in part to the caspase-3 activation , the down-regulation of IAP family proteins , and Bax cleavage mediated by dependent [calpain] *activation* . Positive_regulation CAPN8 CASP10 12469198 1032433 Taken together , the apoptotic effects of NPPA may be related , in part to the caspase-3 activation , the down-regulation of XIAP , and Bax cleavage mediated by *dependent* [calpain] activation . Positive_regulation CAPN8 CASP10 20406947 2256107 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , dependent amplification of mitochondrial depolarization , *activation* of [calpain] , and Bax cleavage . Positive_regulation CAPN8 CASP12 10953012 724240 *Activation* of by [calpain] in apoptosis . Positive_regulation CAPN8 CASP12 11102478 756180 The lack of effect of the PS-1P264L mutation is confirmed by measures of basal- and toxin induced and [calpain] *activation* , biochemical indices of apoptotic and necrotic signaling , respectively . Positive_regulation CAPN8 CASP12 11413236 828632 Cleavage of Bax is mediated by *dependent* or -independent [calpain] activation in dopaminergic neuronal cells : protective role of Bcl-2 . Positive_regulation CAPN8 CASP12 12175527 974739 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Positive_regulation CAPN8 CASP12 12175527 975103 Taken together , the chemopreventive effects of Se-MSC may be related in part to the caspase-3 activation , the down-regulation of IAP family proteins , and Bax cleavage mediated by dependent [calpain] *activation* . Positive_regulation CAPN8 CASP12 12469198 1032443 Taken together , the apoptotic effects of NPPA may be related , in part to the caspase-3 activation , the down-regulation of XIAP , and Bax cleavage mediated by *dependent* [calpain] activation . Positive_regulation CAPN8 CASP12 20406947 2256117 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , dependent amplification of mitochondrial depolarization , *activation* of [calpain] , and Bax cleavage . Positive_regulation CAPN8 CASP14 11102478 756171 The lack of effect of the PS-1P264L mutation is confirmed by measures of basal- and toxin induced and [calpain] *activation* , biochemical indices of apoptotic and necrotic signaling , respectively . Positive_regulation CAPN8 CASP14 11413236 828623 Cleavage of Bax is mediated by *dependent* or -independent [calpain] activation in dopaminergic neuronal cells : protective role of Bcl-2 . Positive_regulation CAPN8 CASP14 12175527 974730 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Positive_regulation CAPN8 CASP14 12175527 975094 Taken together , the chemopreventive effects of Se-MSC may be related in part to the caspase-3 activation , the down-regulation of IAP family proteins , and Bax cleavage mediated by *dependent* [calpain] activation . Positive_regulation CAPN8 CASP14 12469198 1032434 Taken together , the apoptotic effects of NPPA may be related , in part to the caspase-3 activation , the down-regulation of XIAP , and Bax cleavage mediated by dependent [calpain] *activation* . Positive_regulation CAPN8 CASP14 20406947 2256108 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , *dependent* amplification of mitochondrial depolarization , activation of [calpain] , and Bax cleavage . Positive_regulation CAPN8 CASP16 11102478 756181 The lack of effect of the PS-1P264L mutation is confirmed by measures of basal- and toxin induced and [calpain] *activation* , biochemical indices of apoptotic and necrotic signaling , respectively . Positive_regulation CAPN8 CASP16 11413236 828633 Cleavage of Bax is mediated by dependent or -independent [calpain] *activation* in dopaminergic neuronal cells : protective role of Bcl-2 . Positive_regulation CAPN8 CASP16 12175527 974740 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Positive_regulation CAPN8 CASP16 12175527 975104 Taken together , the chemopreventive effects of Se-MSC may be related in part to the caspase-3 activation , the down-regulation of IAP family proteins , and Bax cleavage mediated by *dependent* [calpain] activation . Positive_regulation CAPN8 CASP16 12469198 1032444 Taken together , the apoptotic effects of NPPA may be related , in part to the caspase-3 activation , the down-regulation of XIAP , and Bax cleavage mediated by dependent [calpain] *activation* . Positive_regulation CAPN8 CASP16 20406947 2256118 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , *dependent* amplification of mitochondrial depolarization , activation of [calpain] , and Bax cleavage . Positive_regulation CAPN8 CASP2 11102478 756172 The lack of effect of the PS-1P264L mutation is confirmed by measures of basal- and toxin induced and [calpain] *activation* , biochemical indices of apoptotic and necrotic signaling , respectively . Positive_regulation CAPN8 CASP2 11413236 828624 Cleavage of Bax is mediated by *dependent* or -independent [calpain] activation in dopaminergic neuronal cells : protective role of Bcl-2 . Positive_regulation CAPN8 CASP2 12175527 974731 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Positive_regulation CAPN8 CASP2 12175527 975095 Taken together , the chemopreventive effects of Se-MSC may be related in part to the caspase-3 activation , the down-regulation of IAP family proteins , and Bax cleavage mediated by dependent [calpain] *activation* . Positive_regulation CAPN8 CASP2 12469198 1032435 Taken together , the apoptotic effects of NPPA may be related , in part to the caspase-3 activation , the down-regulation of XIAP , and Bax cleavage mediated by *dependent* [calpain] activation . Positive_regulation CAPN8 CASP2 20406947 2256109 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , dependent amplification of mitochondrial depolarization , *activation* of [calpain] , and Bax cleavage . Positive_regulation CAPN8 CASP3 10751434 681568 Furthermore , D-IFHC revealed a colocalization of [calpain] activation , cyto-c release , and *induction* in these foci , which also revealed progressive TAI . Positive_regulation CAPN8 CASP3 11102478 756173 The lack of effect of the PS-1P264L mutation is confirmed by measures of basal- and toxin induced and [calpain] *activation* , biochemical indices of apoptotic and necrotic signaling , respectively . Positive_regulation CAPN8 CASP3 11124942 794824 This is the first report to our knowledge suggesting a direct link between the early , excitotoxic , calcium mediated activation of [calpain] after cerebral hypoxia-ischemia and the subsequent *activation* of , thus representing a tentative pathway of `` pathological apoptosis . '' Positive_regulation CAPN8 CASP3 11413236 828625 Cleavage of Bax is mediated by dependent or -independent [calpain] *activation* in dopaminergic neuronal cells : protective role of Bcl-2 . Positive_regulation CAPN8 CASP3 12175527 974732 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Positive_regulation CAPN8 CASP3 12175527 975096 Taken together , the chemopreventive effects of Se-MSC may be related in part to the caspase-3 activation , the down-regulation of IAP family proteins , and Bax cleavage mediated by *dependent* [calpain] activation . Positive_regulation CAPN8 CASP3 12469198 1032436 Taken together , the apoptotic effects of NPPA may be related , in part to the caspase-3 activation , the down-regulation of XIAP , and Bax cleavage mediated by dependent [calpain] *activation* . Positive_regulation CAPN8 CASP3 14995081 1182952 We investigated the effect of leupeptin and calpain inhibitor-1 (CAI-1) , two [calpain] *inhibitors* and of a inhibitor , Ac-DEVD-CHO , on functional recovery , myocardial infarct size and apoptosis in isolated rat hearts ( Langendorff technique ) subjected to 30 min of global ischemia and 120 min of reperfusion . Positive_regulation CAPN8 CASP3 15139027 1246979 Glutamate induced apoptosis correlated with upregulation of [calpain] , a proapoptotic shift in the Bax : Bcl-2 ratio , and increased *activation* of . Positive_regulation CAPN8 CASP3 16678266 1569885 In conclusion , we have demonstrated that tributyltin induced cell death through calpain activation , and that intracellular Ca ( 2+ ) increase and activation are *required* for [calpain] activation by tributyltin . Positive_regulation CAPN8 CASP3 18270815 1924696 Results show no activity , but a strong [calpain] activation *involving* both NMDA and non-NMDA receptors . Positive_regulation CAPN8 CASP3 20406947 2256110 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , *dependent* amplification of mitochondrial depolarization , activation of [calpain] , and Bax cleavage . Positive_regulation CAPN8 CASP3 21092655 2350068 in septic mice , myocardial [calpain] was activated and *induced* activation , the association between calpain activation and apoptosis was explored in this experiment . Positive_regulation CAPN8 CASP3 21092655 2350111 myocardial calpain activity is increased in LPS induced septic mice , subsequent caspase-3 activation may contribute to myocardial dysfunction in septic mice without aggravating myocardial apoptosis and Bcl-2 and Bid are not involved on [calpain] *induced* activation in our model . Positive_regulation CAPN8 CASP3 22366184 2606260 Aeromonas hydrophila induced head kidney macrophage apoptosis in Clarias batrachus involves the activation of [calpain] and is *mediated* . Positive_regulation CAPN8 CASP3 22487998 2601645 Pharmacological inhibition of calpain prevented mechanical ventilation induced activation of diaphragmatic caspase-3 and inhibition of *prevented* activation of diaphragmatic [calpain] . Positive_regulation CAPN8 CASP3 22487998 2601702 These findings support our hypothesis that a regulatory calpain/caspase-3 cross-talk exists whereby calpain can promote caspase-3 activation and can *enhance* [calpain] activity in diaphragm muscle during prolonged mechanical ventilation . Positive_regulation CAPN8 CASP3 23425388 2755400 Myocardial [calpain] *induces* myocardial activation and apoptosis in septic mice via the activation of the Hsp90/Akt pathway . Positive_regulation CAPN8 CASP3 23471945 2781887 Interestingly , inhibition of calpain activity also prevented caspase-3 activation , and , conversely , inhibition of *prevented* [calpain] activation . Positive_regulation CAPN8 CASP4 11102478 756174 The lack of effect of the PS-1P264L mutation is confirmed by measures of basal- and toxin induced and [calpain] *activation* , biochemical indices of apoptotic and necrotic signaling , respectively . Positive_regulation CAPN8 CASP4 11413236 828626 Cleavage of Bax is mediated by *dependent* or -independent [calpain] activation in dopaminergic neuronal cells : protective role of Bcl-2 . Positive_regulation CAPN8 CASP4 12175527 974733 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Positive_regulation CAPN8 CASP4 12175527 975097 Taken together , the chemopreventive effects of Se-MSC may be related in part to the caspase-3 activation , the down-regulation of IAP family proteins , and Bax cleavage mediated by dependent [calpain] *activation* . Positive_regulation CAPN8 CASP4 12469198 1032437 Taken together , the apoptotic effects of NPPA may be related , in part to the caspase-3 activation , the down-regulation of XIAP , and Bax cleavage mediated by *dependent* [calpain] activation . Positive_regulation CAPN8 CASP4 20406947 2256111 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , dependent amplification of mitochondrial depolarization , *activation* of [calpain] , and Bax cleavage . Positive_regulation CAPN8 CASP5 11102478 756175 The lack of effect of the PS-1P264L mutation is confirmed by measures of basal- and toxin induced and [calpain] *activation* , biochemical indices of apoptotic and necrotic signaling , respectively . Positive_regulation CAPN8 CASP5 11413236 828627 Cleavage of Bax is mediated by dependent or -independent [calpain] *activation* in dopaminergic neuronal cells : protective role of Bcl-2 . Positive_regulation CAPN8 CASP5 12175527 974734 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Positive_regulation CAPN8 CASP5 12175527 975098 Taken together , the chemopreventive effects of Se-MSC may be related in part to the caspase-3 activation , the down-regulation of IAP family proteins , and Bax cleavage mediated by *dependent* [calpain] activation . Positive_regulation CAPN8 CASP5 12469198 1032438 Taken together , the apoptotic effects of NPPA may be related , in part to the caspase-3 activation , the down-regulation of XIAP , and Bax cleavage mediated by dependent [calpain] *activation* . Positive_regulation CAPN8 CASP5 20406947 2256112 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , *dependent* amplification of mitochondrial depolarization , activation of [calpain] , and Bax cleavage . Positive_regulation CAPN8 CASP6 11102478 756176 The lack of effect of the PS-1P264L mutation is confirmed by measures of basal- and toxin induced and [calpain] *activation* , biochemical indices of apoptotic and necrotic signaling , respectively . Positive_regulation CAPN8 CASP6 11413236 828628 Cleavage of Bax is mediated by *dependent* or -independent [calpain] activation in dopaminergic neuronal cells : protective role of Bcl-2 . Positive_regulation CAPN8 CASP6 12175527 974735 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Positive_regulation CAPN8 CASP6 12175527 975099 Taken together , the chemopreventive effects of Se-MSC may be related in part to the caspase-3 activation , the down-regulation of IAP family proteins , and Bax cleavage mediated by dependent [calpain] *activation* . Positive_regulation CAPN8 CASP6 12469198 1032439 Taken together , the apoptotic effects of NPPA may be related , in part to the caspase-3 activation , the down-regulation of XIAP , and Bax cleavage mediated by *dependent* [calpain] activation . Positive_regulation CAPN8 CASP6 20406947 2256113 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , dependent amplification of mitochondrial depolarization , *activation* of [calpain] , and Bax cleavage . Positive_regulation CAPN8 CASP7 11102478 756177 The lack of effect of the PS-1P264L mutation is confirmed by measures of basal- and toxin induced and [calpain] *activation* , biochemical indices of apoptotic and necrotic signaling , respectively . Positive_regulation CAPN8 CASP7 11413236 828629 Cleavage of Bax is mediated by dependent or -independent [calpain] *activation* in dopaminergic neuronal cells : protective role of Bcl-2 . Positive_regulation CAPN8 CASP7 12175527 974736 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Positive_regulation CAPN8 CASP7 12175527 975100 Taken together , the chemopreventive effects of Se-MSC may be related in part to the caspase-3 activation , the down-regulation of IAP family proteins , and Bax cleavage mediated by *dependent* [calpain] activation . Positive_regulation CAPN8 CASP7 12469198 1032440 Taken together , the apoptotic effects of NPPA may be related , in part to the caspase-3 activation , the down-regulation of XIAP , and Bax cleavage mediated by dependent [calpain] *activation* . Positive_regulation CAPN8 CASP7 20406947 2256114 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , *dependent* amplification of mitochondrial depolarization , activation of [calpain] , and Bax cleavage . Positive_regulation CAPN8 CASP8 11102478 756178 The lack of effect of the PS-1P264L mutation is confirmed by measures of basal- and toxin induced and [calpain] *activation* , biochemical indices of apoptotic and necrotic signaling , respectively . Positive_regulation CAPN8 CASP8 11413236 828630 Cleavage of Bax is mediated by *dependent* or -independent [calpain] activation in dopaminergic neuronal cells : protective role of Bcl-2 . Positive_regulation CAPN8 CASP8 12175527 974737 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Positive_regulation CAPN8 CASP8 12175527 975101 Taken together , the chemopreventive effects of Se-MSC may be related in part to the caspase-3 activation , the down-regulation of IAP family proteins , and Bax cleavage mediated by dependent [calpain] *activation* . Positive_regulation CAPN8 CASP8 12469198 1032441 Taken together , the apoptotic effects of NPPA may be related , in part to the caspase-3 activation , the down-regulation of XIAP , and Bax cleavage mediated by *dependent* [calpain] activation . Positive_regulation CAPN8 CASP8 16618751 1551116 *promotes* cell motility and [calpain] activity under nonapoptotic conditions . Positive_regulation CAPN8 CASP8 20406947 2256115 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , dependent amplification of mitochondrial depolarization , *activation* of [calpain] , and Bax cleavage . Positive_regulation CAPN8 CASP9 11102478 756179 The lack of effect of the PS-1P264L mutation is confirmed by measures of basal- and toxin induced and [calpain] *activation* , biochemical indices of apoptotic and necrotic signaling , respectively . Positive_regulation CAPN8 CASP9 11413236 828631 Cleavage of Bax is mediated by dependent or -independent [calpain] *activation* in dopaminergic neuronal cells : protective role of Bcl-2 . Positive_regulation CAPN8 CASP9 12175527 974738 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Positive_regulation CAPN8 CASP9 12175527 975102 Taken together , the chemopreventive effects of Se-MSC may be related in part to the caspase-3 activation , the down-regulation of IAP family proteins , and Bax cleavage mediated by *dependent* [calpain] activation . Positive_regulation CAPN8 CASP9 12469198 1032442 Taken together , the apoptotic effects of NPPA may be related , in part to the caspase-3 activation , the down-regulation of XIAP , and Bax cleavage mediated by dependent [calpain] *activation* . Positive_regulation CAPN8 CASP9 20406947 2256116 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , *dependent* amplification of mitochondrial depolarization , activation of [calpain] , and Bax cleavage . Positive_regulation CAPN8 CAST 10222112 609589 I , a selective *inhibitor* of [mu-calpain] , also significantly reduced reactive gliosis . Positive_regulation CAPN8 CAST 10601241 574303 Evidence for the involvement of calpain inhibition in this process was obtained by the demonstration that 1 ) somatostatin induced a dose dependent decrease in calpain activity and 2 ) [calpain] *inhibitors* , I and calpeptin , both abolished the cleavage of Hsp 90 and induced a dose dependent increase in [ ( 3 ) H ] dexamethasone binding . Positive_regulation CAPN8 CAST 10942721 722652 In addition , the cells in which [calpain] was constitutively *inhibited* by the overexpression of exhibited a notable morphological change . Positive_regulation CAPN8 CAST 10966930 728253 Because intracellular [calpain] activity is *regulated* by , the effect of I/R on calpastatin was determined . Positive_regulation CAPN8 CAST 12769798 1094598 , an endogenous protein inhibitor , *regulates* the activity of ubiquitous [calpain] . Positive_regulation CAPN8 CAST 14630341 1170445 The activity of [calpain] is strictly *regulated* by calcium concentrations and interactions with ( endogenous calpain inhibitor ) . Positive_regulation CAPN8 CAST 14992597 1215697 In vivo , the activity of [calpain] is *regulated* by its endogenous inhibitor . Positive_regulation CAPN8 CAST 15691895 1388604 The absence of calpain in Capn4-null embryonic fibroblasts and the lowered [calpain] activity in MC3T3-E1 osteoblastic cells *due* to stable expression of the , calpastatin , reduce PTH stimulated cAMP accumulation . Positive_regulation CAPN8 CAST 16076433 1442207 The results showed that in the *presence* of , the labeled [mu-calpain] and antibody would bind to calpastatin , reducing the distance between the two proteins and eliciting a measurable change in fluorescence . Positive_regulation CAPN8 CAST 16385561 1520146 The restoration of pCREB by protein phosphatase (PP)-1/2A inhibitors or the inhibition of excessive *activation* of [calpain] by did not reduce OGD/reoxygenation induced LDH release . Positive_regulation CAPN8 CAST 18001554 1827108 *suppresses* the increased [calpain] activity and reverses the structural remodeling of sustained atrial fibrillation . Positive_regulation CAPN8 CAST 18208663 1857652 , ALLM , *suppressed* the increased [calpain] activity and reversed structural remodeling caused by sustained atrial fibrillation in the present model . Positive_regulation CAPN8 CAST 18395616 1893631 Moreover , MDL-28170 , a , partially rescued the neuron death and *attenuated* the expression of activated [mu-calpain] , cleavage of Bid ( 15 kDa ) , AIF translocation and cytochrome c release . Positive_regulation CAPN8 CAST 18786620 1980646 We have now found that overexpression of the calpain specific inhibitor in differentiated PC12 cells significantly *inhibited* the sAbeta induced [calpain] activation and decreased the protease activity . Positive_regulation CAPN8 CAST 21982763 2497990 Furthermore , depletion of raised calpain activity and *reduced* [calpain] inhibitory activity to similar levels in KD and Control MAEC , indicating that calpastatin is required for PIN1 depletion to lower calpain activity . Positive_regulation CAPN8 CAST 22688056 2633590 In this study , we analyzed the potential therapeutic efficacy of inhibiting the *activation* of [calpain] by a novel in aged 3xTgAD mice with well established cognitive impairment , plaques , and tangles . Positive_regulation CAPN8 CAST 23365236 2738967 Three [calpain] *inhibitors* , I , MDL-28170 , and PD150606 , but not the control compound PD145305 , inhibit LFD both in the intact animal as shown by electromyograms and by intracellular recordings at neuromuscular junctions . Positive_regulation CAPN8 CAST 24441549 2922911 In calpastatin transgenic mice , an endogenous and cultured neonatal mouse cardiomyocytes overexpressing calpastatin also *inhibited* [calpain] activity , I?Ba protein degradation , and NF-?B activation after LPS treatment . Positive_regulation CAPN8 CAST 7585879 325617 I preferentially *inhibits* micro ( mu ) [-calpain] while inhibitor II inhibits milli ( m)-calpain . Positive_regulation CAPN8 CGA 22673225 2632948 Injection of a calpain inhibitor in vivo reduced 1 ) human chorionic *stimulated* [calpain] enzyme activity , 2 ) cell detachment , 3 ) membrane protrusion formation , and 4 ) COC expansion by mechanisms that did not alter Has2 expression . Positive_regulation CAPN8 CGB8 22673225 2632947 Injection of a calpain inhibitor in vivo reduced 1 ) human chorionic *stimulated* [calpain] enzyme activity , 2 ) cell detachment , 3 ) membrane protrusion formation , and 4 ) COC expansion by mechanisms that did not alter Has2 expression . Positive_regulation CAPN8 CPA1 21516125 2489579 CDDP increased the intracellular calcium concentration ( [ Ca ( 2+ ) ] ( i ) ) in OV2008 but not C13* whereas , a Ca ( 2+ ) -ATPase inhibitor , *caused* this response and [calpain] activation , p73a processing and apoptosis in both cell types . Positive_regulation CAPN8 CREB1 18982459 1989659 After outlining the major features of different cell death mechanisms in general , we then compare them with results obtained in retinal degeneration models , where photoreceptor cell death appears to be governed by , among other things , changes in cyclic nucleotide metabolism , downregulation of the transcription factor , and excessive *activation* of [calpain] and PARP . Positive_regulation CAPN8 CREB1 23799606 2807904 Our results clearly showed that ICV injection of NPD1 at 2 h after reperfusion improves the neurological status of middle cerebral artery occlusion ( MCAO ) rats through the inhibition of [calpain-mediated] TRPC6 proteolysis and the subsequent *activation* of via the Ras/MEK/ERK pathway . Positive_regulation CAPN8 CREB1 24193141 2885934 In conclusion , the results clearly demonstrated that intracerebroventricular injection of EGCG immediately following ischemia , inhibits ERS and improves the neurological status of rats that have undergone middle cerebral artery occlusion via the inhibition of [calpain-mediated] TRPC6 proteolysis and the subsequent *activation* of via the MEK/extracellular signal regulated kinases ( ERK ) pathway . Positive_regulation CAPN8 CREB3 18982459 1989660 After outlining the major features of different cell death mechanisms in general , we then compare them with results obtained in retinal degeneration models , where photoreceptor cell death appears to be governed by , among other things , changes in cyclic nucleotide metabolism , downregulation of the transcription factor , and excessive *activation* of [calpain] and PARP . Positive_regulation CAPN8 CREB3 23799606 2807905 Our results clearly showed that ICV injection of NPD1 at 2 h after reperfusion improves the neurological status of middle cerebral artery occlusion ( MCAO ) rats through the inhibition of [calpain-mediated] TRPC6 proteolysis and the subsequent *activation* of via the Ras/MEK/ERK pathway . Positive_regulation CAPN8 CREB3 24193141 2885935 In conclusion , the results clearly demonstrated that intracerebroventricular injection of EGCG immediately following ischemia , inhibits ERS and improves the neurological status of rats that have undergone middle cerebral artery occlusion via the inhibition of [calpain-mediated] TRPC6 proteolysis and the subsequent *activation* of via the MEK/extracellular signal regulated kinases ( ERK ) pathway . Positive_regulation CAPN8 CREB5 18982459 1989658 After outlining the major features of different cell death mechanisms in general , we then compare them with results obtained in retinal degeneration models , where photoreceptor cell death appears to be governed by , among other things , changes in cyclic nucleotide metabolism , downregulation of the transcription factor , and excessive *activation* of [calpain] and PARP . Positive_regulation CAPN8 CREB5 23799606 2807903 Our results clearly showed that ICV injection of NPD1 at 2 h after reperfusion improves the neurological status of middle cerebral artery occlusion ( MCAO ) rats through the inhibition of [calpain-mediated] TRPC6 proteolysis and the subsequent *activation* of via the Ras/MEK/ERK pathway . Positive_regulation CAPN8 CREB5 24193141 2885933 In conclusion , the results clearly demonstrated that intracerebroventricular injection of EGCG immediately following ischemia , inhibits ERS and improves the neurological status of rats that have undergone middle cerebral artery occlusion via the inhibition of [calpain-mediated] TRPC6 proteolysis and the subsequent *activation* of via the MEK/extracellular signal regulated kinases ( ERK ) pathway . Positive_regulation CAPN8 CST1 7680026 211448 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN8 CST11 7680026 211447 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN8 CST2 7680026 211449 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN8 CST3 7680026 211450 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN8 CST4 7680026 211451 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN8 CST5 7680026 211452 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN8 CST6 7680026 211453 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN8 CST7 7680026 211454 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN8 CST8 7680026 211455 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN8 CST9 7680026 211446 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN8 CTNNB1 17270735 1691689 Here , we show that , in hippocampal neurons , NMDA-receptor dependent activation of [calpain] *induced* the cleavage of at the N terminus , generating stable , truncated forms . Positive_regulation CAPN8 CTSD 16021180 1498102 In contrast , drug treatment caused EndoG translocation , *activation* of [mu-calpain] , and both the synthesis and activation of . Positive_regulation CAPN8 CTSD 7602618 311647 After a low-protein diet was fed for 4 weeks to 1-month-old rats , there was a significant increase in activity in liver , and [calpain] activity was *increased* in lung . Positive_regulation CAPN8 CXCL11 12787142 1096955 Interestingly , *increased* [calpain] activity in undifferentiated keratinocytes , whereas the same chemokine inhibited the calpain activity in fibroblasts . Positive_regulation CAPN8 CXCL11 15713646 1373952 Molecular downregulation or RNA interference mediated depletion of mu-calpain ( calpain 1 ) but not M-calpain ( calpain 2 ) blocked *induced* [calpain] activation and motility . Positive_regulation CAPN8 CXCR3 19470579 2091127 We found that activation of *triggers* [micro-calpain] activity , causing cleavage of the cytoplasmic tail of beta3 integrins at the calpain cleavage sites c'754 and c'747 . Positive_regulation CAPN8 CYCS 16988947 1633727 Predominantly apoptosis occurred following exposure of SH-SY5Y cells to 50 microM APG , 50 microM EGC , 50 microM EGCG and 100 microM GST for 24 hr. Apoptosis was associated with increases in intracellular free [ Ca ( 2+ ) ] and Bax : Bcl-2 ratio , mitochondrial release of and *activation* of caspase-9 , [calpain] and caspase-3 . Positive_regulation CAPN8 CYCS 17039248 1708891 The Hq mutation did not inhibit HI-induced mitochondrial release of or *activation* of [calpain] and caspase-3 . Positive_regulation CAPN8 CYCS 17647244 1793528 Other events in apoptosis included overexpression of Bax , down-regulation of Bcl-2 and some BIRC proteins , mitochondrial release of and Smac into the cytosol , and *activation* of [calpain] , caspase-9 , and caspase-3 . Positive_regulation CAPN8 CYCS 18602901 1947179 Besides , apoptosis was associated with alterations in expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins resulting in an increase in Bax : Bcl-2 ratio , mitochondrial release of and Smac , downregulation of selective baculoviral inhibitor-of-apoptosis repeat containing ( BIRC ) molecules , an increase in intracellular free [ Ca2+ ] , and *activation* of [calpain] and caspase-3 . Positive_regulation CAPN8 CYCS 19894226 2188695 Other events in apoptosis included overexpression of Bax , loss of DeltaPsi ( m ) , mitochondrial release of and Smac into the cytosol , down-regulation of baculoviral inhibitor-of-apoptosis repeat containing proteins , and *activation* of [calpain] , caspase-9 , and caspase-3 . Positive_regulation CAPN8 DBI 16908521 1625902 Suppression of levels by small interfering RNA *inhibited* the t-Bid induced activation of mitochondrial [mu-calpain] and release of apoptosis inducing factor from the mitochondrial intermembrane space and the cleavage of full-length Bid to t-Bid . Positive_regulation CAPN8 DIABLO 17647244 1793529 Other events in apoptosis included overexpression of Bax , down-regulation of Bcl-2 and some BIRC proteins , mitochondrial release of cytochrome c and into the cytosol , and *activation* of [calpain] , caspase-9 , and caspase-3 . Positive_regulation CAPN8 DIABLO 18602901 1947180 Besides , apoptosis was associated with alterations in expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins resulting in an increase in Bax : Bcl-2 ratio , mitochondrial release of cytochrome c and , downregulation of selective baculoviral inhibitor-of-apoptosis repeat containing ( BIRC ) molecules , an increase in intracellular free [ Ca2+ ] , and *activation* of [calpain] and caspase-3 . Positive_regulation CAPN8 DIABLO 19766183 2264306 We propose that inhibition of mitochondrial release and [calpain] *activation* contribute to neuroprotection by TAT-JBD . Positive_regulation CAPN8 DIABLO 19894226 2188696 Other events in apoptosis included overexpression of Bax , loss of DeltaPsi ( m ) , mitochondrial release of cytochrome c and into the cytosol , down-regulation of baculoviral inhibitor-of-apoptosis repeat containing proteins , and *activation* of [calpain] , caspase-9 , and caspase-3 . Positive_regulation CAPN8 DMD 15963350 1423138 Based on pathological , molecular , and physiological findings in 3 animal models and human cases , we propose a novel scheme that a vicious cycle formed by increased sarcolemma ( SL ) permeability , preferential *activation* of [calpain] over calpastatin , and translocation and cleavage of commonly lead to advanced HF . Positive_regulation CAPN8 DYRK1A 19059382 2017868 Moreover , the use of primary hepatocytes/Kupffer cells co-culture showed that degradation of induced by hyperhomocysteinemia *requires* [calpain] activation . Positive_regulation CAPN8 E2F1 16088944 1466296 *induces* cell death , [calpain] activation , and MDMX degradation in a transcription independent manner implicating a novel role for E2F1 in neuronal loss in SIV encephalitis . Positive_regulation CAPN8 EGF 10402474 628972 That this inhibition of EGF induced calpain activity was secondary to IP-10 initiating a cAMP-protein kinase A-calpain cascade is supported by the following evidence : ( a ) the cell permeant analogue 8- ( 4-chlorophenylthio ) -cAMP ( CPT-cAMP ) prevented *induced* [calpain] activity and motility ; Positive_regulation CAPN8 EGF 10402474 628986 ( b ) other ELR negative CXC chemokines , monokine induced by IFN-gamma and platelet factor 4 that also generate cAMP , inhibited *induced* cell migration and [calpain] activation ; Positive_regulation CAPN8 EGF 10644690 661295 induced rapid activation of calpain that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway , and [calpain] was *stimulated* by transfection of constitutively active MEK . Positive_regulation CAPN8 EGF 11319218 827111 Cells transfected with membrane targeted ERK1 and ERK2 , which sequester endogenous ERKs , exhibited normal *induced* [calpain] activity . Positive_regulation CAPN8 EGF 11319218 827125 These data strongly suggest that *induced* [calpain] activity can be enhanced near sites of membrane-proximal EGFR mediated ERK signaling , providing insights about how calpain activity might be regulated and targeted to enhance its effects on adhesion related substrates . Positive_regulation CAPN8 EGF 11909964 924039 *induced* [calpain] activation was inhibited by cAMP activation of protein kinase A (PKA) , as the PKA inhibitors H-89 and Rp-8Br-cAMPS abrogated cAMP inhibition of both motility and calpain activation . Positive_regulation CAPN8 EGF 11909964 924053 cAMP suppressed *induced* [calpain] activity of cells overexpressing a control wild-type human m-calpain ( 83 % +/- 3.7 % inhibition ) but only marginally suppressed that of cells expressing the PKA-resistant mutant human m-calpain ( 25 % +/- 5.5 % inhibition ) . Positive_regulation CAPN8 EGF 14993287 1216019 We identified serine 50 as required for induced [calpain] *activation* in vitro and in vivo . Positive_regulation CAPN8 EGF 14993287 1216034 *triggers* [calpain] even in the presence of intracellular calcium chelators and in calcium-free media . Positive_regulation CAPN8 EGF 15713646 1373970 These data demonstrate that while both and IP-9 induced motility in keratinocytes *requires* [calpain] activity , the isoform of calpain triggered depends on the nature of the receptor for the particular ligand . Positive_regulation CAPN8 EGF 16809781 1580568 Downregulation of phosphoinositide production by 1-butanol resulted in diminished PIP ( 2 ) in the plasma membrane and eliminated *induced* [calpain] activation . Positive_regulation CAPN8 EGF 20089917 2201559 Remarkably , BDNF- and *induced* [calpain] activation was preferentially localized in dendrites and dendritic spines of hippocampal neurons and was associated with actin polymerization , which was prevented by calpain inhibition . Positive_regulation CAPN8 EGF 22673225 2632979 The latter are controlled by [calpain] *activation* downstream of the receptor activation of the Ca ( 2+ ) pathway and ERK1/2 pathways . Positive_regulation CAPN8 EGFR 11983008 935412 The mitogen activated protein kinase kinase-1-selective inhibitor PD 98059 that blocks signaling through the extracellular signal regulated kinase/mitogen activated protein kinase pathway , required for mediated *activation* of [calpain] and de-adhesion , does not significantly affect the magnitude of matrix contraction within minutes of epidermal growth factor addition , but slows the decay similarly to calpain inhibition . Positive_regulation CAPN8 EGFR 18258859 1884906 In vitro experiments using vascular smooth muscle cells showed that calpastatin transgene expression blunted [calpain] *activation* by Ang II through transactivation . Positive_regulation CAPN8 ENDOG 20484155 2288652 In contrast , in MCF-7 cells the death process was executed in a caspase independent but calpain dependent manner as [calpain] *activation* induced cleavage of cytosolic alpha-fodrin , stimulated mitochondrial release of apoptotic inducing factor and , and thus harmonized cytosolic and mitochondrial death signals to accomplish apoptosis . Positive_regulation CAPN8 EPHB2 18443189 1926665 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN8 EPHB2 23408424 2764604 We unravel novel mechanisms for activity- and *dependent* [calpain] action on gephyrin , which are likely relevant in the context of cellular signaling affecting GABAergic transmission and homeostatic synaptic plasticity in pathology . Positive_regulation CAPN8 ERVK-6 7718599 301344 Although the degradation of [mu-calpain] was not *inhibited* by various inhibitors , it was strongly inhibited by digestible substrates for calpain that possess the ability to inhibit the binding of mu-calpain to erythrocyte membranes . Positive_regulation CAPN8 ESR1 19995977 2176557 Activation of and ERbeta receptors by specific agonists *stimulated* [calpain] activity . Positive_regulation CAPN8 ESR2 19995977 2176558 Activation of ERalpha and receptors by specific agonists *stimulated* [calpain] activity . Positive_regulation CAPN8 F13A1 2883970 73116 *Activation* of platelet by [calpain] was inhibited by EDTA , leupeptin , and endogenous calpain-specific inhibitor calpastatin . Positive_regulation CAPN8 F13B 2883970 73117 *Activation* of platelet by [calpain] was inhibited by EDTA , leupeptin , and endogenous calpain-specific inhibitor calpastatin . Positive_regulation CAPN8 FASLG 23283937 2745959 Functionally , *induced* apoptosis and activation of [calpain] and calcineurin , the Ca ( 2+ ) sensitive proteins that mediate apoptosis , were significantly attenuated by silencing TRP-ML1 gene but enhanced by overexpression of TRP-ML1 gene . Positive_regulation CAPN8 FGB 8999848 409827 In human platelets , [calpain] activation is *dependent* on binding to integrin alphaIIbbeta3 and subsequent platelet aggregation , suggesting a potential role for this protease in the regulation of postaggregation responses . Positive_regulation CAPN8 FGF2 9089209 421810 The intensity of the cytoplasmic calpain immunoreactivity was significantly decreased in the nuclear and non-nuclear regions of the cytoplasm , respectively , following withdrawal of cAMP at 144 hr. Removal of from the medium *resulted* in an increase of cytoplasmic [calpain] immunoreactivity in the nuclear regions and cytoplasm , while there was dramatic loss of myelin calpain immunoreactivity from both the nuclear region and cytoplasm . Positive_regulation CAPN8 GP1BA 9268316 449820 In contrast , [calpain] activation in vWf stimulated platelets *required* ligand binding to both and integrin alphaIIbbeta3 . Positive_regulation CAPN8 GP1BB 9268316 449821 In contrast , [calpain] activation in vWf stimulated platelets *required* ligand binding to both and integrin alphaIIbbeta3 . Positive_regulation CAPN8 GRIN2B 16356733 1533269 At moderate injury levels , both caspase-3 and [calpain] activation was *attenuated* by blocking containing NMDARs prior to stretch or by blocking all NMDARs prior to stretch injury . Positive_regulation CAPN8 GRP 20823585 2318517 Moreover , we demonstrated that IPA triggered endoplasmic reticulum ( ER ) stress , as shown by changes in cytosol-calcium level , *activation* of [mu-calpain] and caspase-12 , and up-regulation of and growth arrest DNA damage-inducible gene 153 ( GADD153 ) . Positive_regulation CAPN8 HDAC1 17986223 1850597 Interestingly , did not *induce* caspase and [calpain] activation , suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways . Positive_regulation CAPN8 HDAC2 17986223 1850598 Interestingly , did not *induce* caspase and [calpain] activation , suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways . Positive_regulation CAPN8 HIF1A 17989922 1835737 Degradation of *required* intracellular calcium transients and [calpain] activation . Positive_regulation CAPN8 HMOX1 23739547 2828066 Inhibition of with a pharmacological inhibitor or siRNA and knockdown of Nrf2 *suppressed* the stimulatory effects of tBHQ on ABCA1 expression and [calpain] activity . Positive_regulation CAPN8 HTN1 2145987 143995 Whereas the extent of calpain activation of erythrocyte membrane Ca2 ( + ) -pumping ATPase of normal subjects was almost equal to that due to calmodulin , [calpain] *activation* of the and SCA pump was greater than activation by calmodulin . Positive_regulation CAPN8 HTN3 2145987 143996 Whereas the extent of calpain activation of erythrocyte membrane Ca2 ( + ) -pumping ATPase of normal subjects was almost equal to that due to calmodulin , [calpain] *activation* of the and SCA pump was greater than activation by calmodulin . Positive_regulation CAPN8 IFNG 18211896 1895458 *induced* [calpain] expression and activation and increased the phosphorylation and degradation of the calpain substrate ABCA1 in 1542CP3TX cancer cells . Positive_regulation CAPN8 IL13 23881867 2865979 also *enhanced* ER stress evoked [calpain] activation by promoting the association of C/EBP-ß and PPAR-? . Positive_regulation CAPN8 IL8 12649322 1072417 Further , both [calpain] inhibition and *stimulation* with and formyl-Met-Leu-Phe ( fMLP ) induced an increase in Cdc42 and Rac activation . Positive_regulation CAPN8 ITGA2 16461767 1534556 mediated ERK and [calpain] *activation* play a critical role in cell adhesion and motility via focal adhesion kinase signaling : identification of a novel signaling pathway . Positive_regulation CAPN8 ITGA2B 9074630 419974 In thrombin stimulated platelets engagement *triggers* both phosphatidylinositol 3',4'-bisphosphate synthesis and [calpain] activation . Positive_regulation CAPN8 ITGB2 16002691 1431002 Experiments performed with specific inhibitors revealed that entry of HIV-1 in activated CD4 ( + ) T cells is regulated by *dependent* ZAP70 , phospholipase Cgamma1 , and [calpain] enzymatic activities . Positive_regulation CAPN8 ITGB3 9074630 419975 In thrombin stimulated platelets engagement *triggers* both phosphatidylinositol 3',4'-bisphosphate synthesis and [calpain] activation . Positive_regulation CAPN8 LPA 20420580 2246760 Interestingly , LPA induced down-regulation of MAG was significantly inhibited by calpain inhibitors ( calpain inhibitor X , E-64 and E-64d ) and markedly *induced* [calpain] activation in the DR . Positive_regulation CAPN8 LPA 20420580 2246788 The present study provides strong evidence that *induced* [calpain] activation plays a crucial role in the manifestation of neuropathic pain through MAG down-regulation in the DR . Positive_regulation CAPN8 MAP2K1 10644690 661296 EGF induced rapid activation of [calpain] that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway , and calpain was *stimulated* by transfection of constitutively active . Positive_regulation CAPN8 MAP2K1 18443189 1926669 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN8 MAP2K2 10644690 661297 EGF induced rapid activation of calpain that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway , and [calpain] was *stimulated* by transfection of constitutively active . Positive_regulation CAPN8 MAP2K2 18443189 1926670 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN8 MAP2K3 10644690 661298 EGF induced rapid activation of [calpain] that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway , and calpain was *stimulated* by transfection of constitutively active . Positive_regulation CAPN8 MAP2K3 18443189 1926671 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN8 MAP2K4 10644690 661299 EGF induced rapid activation of calpain that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway , and [calpain] was *stimulated* by transfection of constitutively active . Positive_regulation CAPN8 MAP2K4 18443189 1926672 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN8 MAP2K5 10644690 661300 EGF induced rapid activation of [calpain] that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway , and calpain was *stimulated* by transfection of constitutively active . Positive_regulation CAPN8 MAP2K5 18443189 1926673 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN8 MAP2K6 10644690 661301 EGF induced rapid activation of calpain that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway , and [calpain] was *stimulated* by transfection of constitutively active . Positive_regulation CAPN8 MAP2K6 18443189 1926674 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN8 MAP2K7 10644690 661302 EGF induced rapid activation of [calpain] that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway , and calpain was *stimulated* by transfection of constitutively active . Positive_regulation CAPN8 MAP2K7 18443189 1926675 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN8 MAP3K1 12839996 1108235 is *required* for activation of the cysteine protease [calpain] and cleavage of spectrin and talin , proteins linking focal adhesions to the cytoskeleton . Positive_regulation CAPN8 MAPK3 22673225 2632965 During EGF-like factor induction of COC expansion in culture , [calpain] activity was *increased* by and intracellular Ca ( 2+ ) signaling pathways . Positive_regulation CAPN8 MET 12649322 1072418 Further , both [calpain] inhibition and *stimulation* with IL-8 and ( fMLP ) induced an increase in Cdc42 and Rac activation . Positive_regulation CAPN8 MMP1 17192848 1702053 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN8 MMP10 17192848 1702054 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN8 MMP11 17192848 1702055 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN8 MMP12 17192848 1702056 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN8 MMP13 17192848 1702057 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN8 MMP14 17192848 1702058 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN8 MMP15 17192848 1702059 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN8 MMP16 17192848 1702060 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN8 MMP17 17192848 1702061 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN8 MMP19 17192848 1702062 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN8 MMP2 17192848 1702063 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN8 MMP20 17192848 1702064 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN8 MMP21 17192848 1702051 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN8 MMP24 17192848 1702065 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN8 MMP25 17192848 1702048 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN8 MMP26 17192848 1702049 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN8 MMP27 17192848 1702050 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN8 MMP28 17192848 1702052 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN8 MMP3 17192848 1702066 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN8 MMP7 17192848 1702067 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN8 MMP8 17192848 1702068 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN8 MMP9 17192848 1702069 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN8 MPZ 24341912 2942354 ( + ) and rotenone dose-dependently elevated the levels of intracellular free Ca ( 2+ ) and *induced* a concomitant rise in the levels of active [calpain] . Positive_regulation CAPN8 MYC 18544539 1940536 *stimulated* [calpain] activity by suppressing calpastatin expression , the endogenous calpain inhibitor . Positive_regulation CAPN8 NEFH 10540027 563240 We observed no differences between control and ALS in the characteristics of NFH , including migration patterns on 2D-IEF , sensitivity to E. coli , alkaline phosphatase mediated dephosphorylation , peptide mapping , or proteolysis ( calpain , [calpain/calmodulin] *mediated* , phosphorylated or dephosphorylated ) . Positive_regulation CAPN8 NM 18443189 1926501 We studied the mechanisms underlying [calpain] inhibition *mediated* human . Positive_regulation CAPN8 NM 18443189 1926676 The studies with pharmacological inhibitors suggest that [calpain] inhibition *mediated* is mediated by activation of MEK/ERK , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN8 NOS1 11054482 745406 This allows a large increase in cytosolic Ca ( 2+ ) associated with activation of [mu-calpain] , calcineurin , and phospholipases with consequent proteolysis of calpain substrates ( including spectrin and eIF4G ) , *activation* of and potentially of Bad , and accumulation of free arachidonic acid , which can induce depletion of Ca ( 2+ ) from the ER lumen . Positive_regulation CAPN8 NOS2 11852433 893544 Considering our previous result that the elevation of calcium content is also prevented by AG-treatment , it is conceivable that upregulation of *causes* calcium influx into lens cells and the subsequent activation of [calpain] . Positive_regulation CAPN8 NOX1 18950702 2014188 Taurine prevents cardiomyocyte death by inhibiting mediated [calpain] *activation* . Positive_regulation CAPN8 NOX1 18950702 2014258 In conclusion , *induces* [calpain] activation , leading to apoptosis in NE-induced cardiomyocytes . Positive_regulation CAPN8 NOX1 18950702 2014370 Thus , inhibition of mediated [calpain] *activation* may be an important mechanism for taurine 's antiapoptotic action in cardiomyocytes . Positive_regulation CAPN8 NOX1 23994487 2851212 Results suggest that phospholipase A2 and *contribute* to the early activation of [calpain] after glucose deprivation . Positive_regulation CAPN8 NOX3 18950702 2014189 Taurine prevents cardiomyocyte death by inhibiting mediated [calpain] *activation* . Positive_regulation CAPN8 NOX3 18950702 2014259 In conclusion , *induces* [calpain] activation , leading to apoptosis in NE-induced cardiomyocytes . Positive_regulation CAPN8 NOX3 18950702 2014371 Thus , inhibition of mediated [calpain] *activation* may be an important mechanism for taurine 's antiapoptotic action in cardiomyocytes . Positive_regulation CAPN8 NOX3 23994487 2851213 Results suggest that phospholipase A2 and *contribute* to the early activation of [calpain] after glucose deprivation . Positive_regulation CAPN8 NOX4 18950702 2014190 Taurine prevents cardiomyocyte death by inhibiting mediated [calpain] *activation* . Positive_regulation CAPN8 NOX4 18950702 2014260 In conclusion , *induces* [calpain] activation , leading to apoptosis in NE-induced cardiomyocytes . Positive_regulation CAPN8 NOX4 18950702 2014372 Thus , inhibition of mediated [calpain] *activation* may be an important mechanism for taurine 's antiapoptotic action in cardiomyocytes . Positive_regulation CAPN8 NOX4 23994487 2851214 Results suggest that phospholipase A2 and *contribute* to the early activation of [calpain] after glucose deprivation . Positive_regulation CAPN8 NOX5 18950702 2014187 Taurine prevents cardiomyocyte death by inhibiting mediated [calpain] *activation* . Positive_regulation CAPN8 NOX5 18950702 2014257 In conclusion , *induces* [calpain] activation , leading to apoptosis in NE-induced cardiomyocytes . Positive_regulation CAPN8 NOX5 18950702 2014369 Thus , inhibition of mediated [calpain] *activation* may be an important mechanism for taurine 's antiapoptotic action in cardiomyocytes . Positive_regulation CAPN8 NOX5 23994487 2851211 Results suggest that phospholipase A2 and *contribute* to the early activation of [calpain] after glucose deprivation . Positive_regulation CAPN8 NR3C2 11846407 912470 Instead , *activated* [calpain] in rat hepatocytes , probably through the increase of intracellular Ca ( 2+ ) released from mitochondria . Positive_regulation CAPN8 NR3C2 11846407 912484 Both ALLN and ALLM , two calpain inhibitors , significantly blocked induced [calpain] *activation* and subsequent cell death . Positive_regulation CAPN8 NR3C2 11846407 912498 CsA also prevented induced [calpain] *activation* and cell death , suggesting that the activation of calpain may be a post-mitochondrial event . Positive_regulation CAPN8 PARP1 12609713 1063311 TG-induced apoptosis was assessed by morphological changes , DNA fragmentation , cleavages of poly ( ADP-ribose ) polymerase ( ) , and *activation* of [calpain] and caspase-12 . Positive_regulation CAPN8 PARP1 19427306 2101267 Activation of PARP-1 is necessary for calpain activation as inhibition *blocked* mitochondrial [calpain] activation . Positive_regulation CAPN8 PARP10 12609713 1063306 TG-induced apoptosis was assessed by morphological changes , DNA fragmentation , cleavages of poly ( ADP-ribose ) polymerase ( ) , and *activation* of [calpain] and caspase-12 . Positive_regulation CAPN8 PARP11 12609713 1063303 TG-induced apoptosis was assessed by morphological changes , DNA fragmentation , cleavages of poly ( ADP-ribose ) polymerase ( ) , and *activation* of [calpain] and caspase-12 . Positive_regulation CAPN8 PARP12 12609713 1063304 TG-induced apoptosis was assessed by morphological changes , DNA fragmentation , cleavages of poly ( ADP-ribose ) polymerase ( ) , and *activation* of [calpain] and caspase-12 . Positive_regulation CAPN8 PARP14 12609713 1063315 TG-induced apoptosis was assessed by morphological changes , DNA fragmentation , cleavages of poly ( ADP-ribose ) polymerase ( ) , and *activation* of [calpain] and caspase-12 . Positive_regulation CAPN8 PARP15 12609713 1063309 TG-induced apoptosis was assessed by morphological changes , DNA fragmentation , cleavages of poly ( ADP-ribose ) polymerase ( ) , and *activation* of [calpain] and caspase-12 . Positive_regulation CAPN8 PARP16 12609713 1063307 TG-induced apoptosis was assessed by morphological changes , DNA fragmentation , cleavages of poly ( ADP-ribose ) polymerase ( ) , and *activation* of [calpain] and caspase-12 . Positive_regulation CAPN8 PARP2 12609713 1063313 TG-induced apoptosis was assessed by morphological changes , DNA fragmentation , cleavages of poly ( ADP-ribose ) polymerase ( ) , and *activation* of [calpain] and caspase-12 . Positive_regulation CAPN8 PARP3 12609713 1063314 TG-induced apoptosis was assessed by morphological changes , DNA fragmentation , cleavages of poly ( ADP-ribose ) polymerase ( ) , and *activation* of [calpain] and caspase-12 . Positive_regulation CAPN8 PARP4 12609713 1063312 TG-induced apoptosis was assessed by morphological changes , DNA fragmentation , cleavages of poly ( ADP-ribose ) polymerase ( ) , and *activation* of [calpain] and caspase-12 . Positive_regulation CAPN8 PARP6 12609713 1063310 TG-induced apoptosis was assessed by morphological changes , DNA fragmentation , cleavages of poly ( ADP-ribose ) polymerase ( ) , and *activation* of [calpain] and caspase-12 . Positive_regulation CAPN8 PARP8 12609713 1063308 TG-induced apoptosis was assessed by morphological changes , DNA fragmentation , cleavages of poly ( ADP-ribose ) polymerase ( ) , and *activation* of [calpain] and caspase-12 . Positive_regulation CAPN8 PARP9 12609713 1063305 TG-induced apoptosis was assessed by morphological changes , DNA fragmentation , cleavages of poly ( ADP-ribose ) polymerase ( ) , and *activation* of [calpain] and caspase-12 . Positive_regulation CAPN8 PDK1 23071514 2685900 Pro-death activity of violacein is actually carried out by inhibition of [calpain] and DAPK1 and *activation* of PKA , AKT and , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation CAPN8 PDK2 23071514 2685901 Pro-death activity of violacein is actually carried out by inhibition of [calpain] and DAPK1 and *activation* of PKA , AKT and , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation CAPN8 PDK3 23071514 2685902 Pro-death activity of violacein is actually carried out by inhibition of [calpain] and DAPK1 and *activation* of PKA , AKT and , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation CAPN8 PDK4 23071514 2685903 Pro-death activity of violacein is actually carried out by inhibition of [calpain] and DAPK1 and *activation* of PKA , AKT and , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation CAPN8 PGP 10493948 646896 These results indicated that [calpain] involved Pgp turnover and that calpain inhibition *induced* ubiquitinated mainly at the cell surface membrane with a reduction in its own functions suggesting that the modulation of Pgp-turnover involves MDR-reversal by another approach . Positive_regulation CAPN8 PI3 18443189 1926677 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of MEK/ERK , p38 , JNK , , and Rac . Positive_regulation CAPN8 PLA2G1B 23994487 2851215 Results suggest that and NADPH oxidase *contribute* to the early activation of [calpain] after glucose deprivation . Positive_regulation CAPN8 PLA2G1B 8655597 364678 Melittin , a activator , *increased* [calpain] activity and cell necrosis in all cell types ; Positive_regulation CAPN8 PLCB3 15713646 1373928 The increases in both motility and [calpain] activity by IP-9 were *blocked* by pharmacological and molecular inhibition of and chelation of calcium , which prevented an intracellular calcium flux . Positive_regulation CAPN8 PPARGC1A 18718443 1968302 Oxidants and Ca+2 *induce* degradation through [calpain] . Positive_regulation CAPN8 PRKCA 10868631 706533 We investigated the mechanisms of cytoprotection by PGE1 , focusing on the elevation of intracellular calcium ( [ Ca2+ ] i ) , activation of [calpain-mu] , and calpain-mu mediated *activation* of . Positive_regulation CAPN8 RAC1 18443189 1926678 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of MEK/ERK , p38 , JNK , PI-3K/Akt , and . Positive_regulation CAPN8 RAC2 18443189 1926679 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of MEK/ERK , p38 , JNK , PI-3K/Akt , and . Positive_regulation CAPN8 RAC3 18443189 1926680 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of MEK/ERK , p38 , JNK , PI-3K/Akt , and . Positive_regulation CAPN8 RBBP4 17986223 1850599 Interestingly , did not *induce* caspase and [calpain] activation , suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways . Positive_regulation CAPN8 RBBP7 17986223 1850600 Interestingly , did not *induce* caspase and [calpain] activation , suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways . Positive_regulation CAPN8 RHOA 19778902 2202892 We also found that ras activates a GTPase , that RhoA *promotes* activation of a protease [calpain] , and that calpain triggers degradation of Beclin-1 , a critical mediator of autophagy , in these cells . Positive_regulation CAPN8 SAP130 17986223 1850596 Interestingly , did not *induce* caspase and [calpain] activation , suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways . Positive_regulation CAPN8 SAP30 17986223 1850593 Interestingly , did not *induce* caspase and [calpain] activation , suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways . Positive_regulation CAPN8 SEC61B 8638921 358362 calpain inhibitors calpeptin and E-64d *inhibited* platelet aggregation , [mu-calpain] activation , and the limited proteolysis of talin . Positive_regulation CAPN8 SIN3A 17986223 1850595 Interestingly , did not *induce* caspase and [calpain] activation , suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways . Positive_regulation CAPN8 TAT 20962236 2338247 also *increases* [calpain] protease activity at the PM , demonstrated by total internal reflection fluorescence microscopy of a cleavable fluorescent calpain substrate . Positive_regulation CAPN8 TGFB1 9428805 482015 Cell associated *activation* of latent by [calpain] . Positive_regulation CAPN8 TGFB2 9428805 482016 Cell associated *activation* of latent by [calpain] . Positive_regulation CAPN8 TGFB3 9428805 482017 Cell associated *activation* of latent by [calpain] . Positive_regulation CAPN8 TLN1 8638921 358358 Membrane-permeable calpain inhibitors calpeptin and E-64d inhibited platelet aggregation , [mu-calpain] *activation* , and the limited proteolysis of . Positive_regulation CAPN8 TLN2 8638921 358361 Membrane-permeable calpain inhibitors calpeptin and E-64d inhibited platelet aggregation , [mu-calpain] *activation* , and the limited proteolysis of . Positive_regulation CAPN8 TLR2 21825064 2485401 Inhibition of prevented H. pylori *induced* [calpain] activation and AJ disassembly . Positive_regulation CAPN8 TNF 11281557 798926 Cytoprotective effect of prednisolone in hepatic IR injury was closely associated with suppression of production and [calpain] mu *activation* . Positive_regulation CAPN8 TNF 11288141 800390 Results of this study suggest may *induce* caspase-3 activation but not [calpain] activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation CAPN8 TNF 16574073 1543492 Tumor necrosis factor ( ) stimulation *induced* increased expression of [mu-calpain] , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation CAPN8 TNFSF11 15955824 1440663 To clarify the role of calpain in the receptor activator of NF-kappaB ligand ( RANKL ) -supported osteoclastogenesis , induced [calpain] *activation* was examined by using murine RAW 264.7 cells and bone marrow derived monocyte/macrophage progenitors . Positive_regulation CAPN8 TNFSF11 15955824 1440691 We found that calpain activity increased in *response* to in both cell types based on alpha-spectrinolysis and that [mu-calpain] , rather than m-calpain , was activated during RANKL supported osteoclastogenesis in RAW 264.7 cells . Positive_regulation CAPN8 TP53 17113081 1661137 KLF6 degradation occurred in the *presence* or absence of , was associated with ubiquitination , mediated by the proteasome ( half-life 16min , unstimulated ) , and independent of caspases and [calpain] . Positive_regulation CAPN8 UFD1L 8638921 358359 calpain inhibitors calpeptin and E-64d *inhibited* platelet aggregation , [mu-calpain] activation , and the limited proteolysis of talin . Positive_regulation CAPN8 VCP 8638921 358360 calpain inhibitors calpeptin and E-64d *inhibited* platelet aggregation , [mu-calpain] activation , and the limited proteolysis of talin . Positive_regulation CAPN8 VEGFA 16816119 1580969 Incubation of PMEC with a VEGF receptor blocker prevented the *induced* increase in [calpain] activity . Positive_regulation CAPN8 VEGFA 19038867 2017388 Both also diminished membrane-specific [calpain] *activation* by , which was intriguingly attenuated by silencing ezrin with RNA interference . Positive_regulation CAPN8 VWF 8896411 392693 Investigation of the mechanisms involved in shear dependent microparticle generation showed that binding of to platelet glycoprotein lb , influx of extracellular calcium , and *activation* of platelet [calpain] were required to generate microparticles under high shear stress conditions . Positive_regulation CAPN9 CST6 7680026 211463 These results indicate that decreased FDR of skeletal muscle from growing bulls contributes to their greater efficiency of growth and could be related partially to *mediated* cathepsin activity and ( or ) calpastatin mediated [calpain] activity . Positive_regulation CAPN9 EPHB2 18443189 1926681 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN9 EPHB2 23408424 2764605 We unravel novel mechanisms for activity- and *dependent* [calpain] action on gephyrin , which are likely relevant in the context of cellular signaling affecting GABAergic transmission and homeostatic synaptic plasticity in pathology . Positive_regulation CAPN9 ITGB2 16002691 1431003 Experiments performed with specific inhibitors revealed that entry of HIV-1 in activated CD4 ( + ) T cells is regulated by *dependent* ZAP70 , phospholipase Cgamma1 , and [calpain] enzymatic activities . Positive_regulation CAPN9 MAP2K6 10644690 661309 EGF induced rapid activation of [calpain] that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway , and calpain was *stimulated* by transfection of constitutively active . Positive_regulation CAPN9 MAP2K6 18443189 1926690 The studies with pharmacological inhibitors suggest that [calpain] inhibition mediated neutrophil migration is *mediated* by activation of , p38 , JNK , PI-3K/Akt , and Rac . Positive_regulation CAPN9 MMP28 17192848 1702074 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN9 MMP7 17192848 1702089 Our results revealed that ( 1 ) the intracellular cGMP levels and the mitochondria decreased , and [calpain] and caspases were *activated* , during beta-lapachone induced endothelial cell death ; Positive_regulation CAPN9 TNF 11281557 798927 Cytoprotective effect of prednisolone in hepatic IR injury was closely associated with suppression of production and [calpain] mu *activation* . Positive_regulation CAPN9 TNF 11288141 800391 Results of this study suggest may *induce* caspase-3 activation but not [calpain] activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation CAPN9 TNF 16574073 1543493 ( TNF-alpha ) stimulation *induced* increased expression of [mu-calpain] , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation CAPNS1 EPHB2 19946123 2190645 *regulates* [calpain 2-induced] androgen receptor proteolysis in CWR22 relapsed prostate tumor cell lines . Positive_regulation CAPS IL1B 19364880 2074604 It also indicated that [CAPS] is entirely *mediated* by and that canakinumab treatment restores physiological IL-1beta production . Positive_regulation CAPS IL1B 19501000 2098118 The central *role* of in [CAPS] is supported by the response to IL-1 targeted therapy . Positive_regulation CAPS IL1B 19649332 2118959 Kineret ( R ) or anakinra/ Amgen , Inc. ) , not only provided supportive evidence for the *role* of in [CAPS] but also demonstrated the efficacy of targeting IL-1beta for treatment of these conditions . Positive_regulation CAPS IL1B 19707454 2009177 The selective blockade of IL-1beta , with anakinra ( IL-1 receptor antagonist ) , not only provided supportive evidence for the *role* of in [CAPS] , but also demonstrated the efficacy of targeting IL-1beta for treatment of these conditions . Positive_regulation CARD6 CAPN8 15209509 1261834 In U87-MG cells , activity was *required* for release of [CARd6] with shed vesicles , and accumulation of CARd6 in cells that rounded up and released from the plastic substrate in response to A23187 treatment was blocked by N-ethylmaleimide . Positive_regulation CARD8 TNF 17878386 1797050 Moreover , and overexpression of p65 *induced* the formation of [NF-kappaB-CARD8] promoter complexes . Positive_regulation CASP1 CAPN8 11449356 836157 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Positive_regulation CASP1 CAPN8 12358768 994288 Calpain inhibitor III ( MDL-28170 ) reduced caspase activation , suggesting that [caspase] activation was *mediated* by . Positive_regulation CASP1 CAPN8 12917442 1150993 Interestingly , the overexpression of parkin induced the activation of an intracellular cysteine protease , calpain , but not [caspase] , and the cytoprotective effect of parkin on alpha-synuclein cytotoxicity was significantly *inhibited* by the presence of inhibitors . Positive_regulation CASP1 CAPN8 16597613 1604190 However , PD-150606 also attenuated caspase-3 activity and apoptosis at 24 h , suggesting *dependent* [caspase] activation . Positive_regulation CASP1 CCND1 12480939 1078940 Bcl-2 controls [caspase] activation *following* a p53 dependent death signal . Positive_regulation CASP1 EPHB2 15304372 1322265 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Positive_regulation CASP1 EPHB2 16397410 1512918 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP1 EPHB2 17192846 1701814 These effects were paralleled by disruption of Ras -- > and Akt survival pathways , consequent decreased phosphorylation of both mitochondrial bcl-2 and bad proteins , and [caspase] *activation* . Positive_regulation CASP1 EPHB2 19709398 2139126 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Positive_regulation CASP1 EPHB2 20177944 2236685 This [caspase] activation is *mediated* by phosphorylation of Akt and . Positive_regulation CASP1 EPHB2 21364665 2361068 dependent multiple [caspase] *activation* by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP1 EPHB2 22193398 2543463 Overexpression of ZnT-1 markedly reduced LDH release and caspase activation following I/R. Knockdown of endogenous ZnT-1 augmented the I/R induced release of LDH and increased [caspase] *activation* following I/R. levels were significantly increased following I/R in cells overexpressing ZnT-1 , while knockdown of ZnT-1 reduced phospho-ERK levels . Positive_regulation CASP1 EPHB2 22554503 2590589 The activation of increased XIAP expression and *led* to decreased [caspase] activation . Positive_regulation CASP1 FAS 10213689 608069 *induced* [caspase] denitrosylation . Positive_regulation CASP1 FAS 10352269 617202 In strict contrast , TPA is an ineffective inhibitor when cell death is induced by the potassium ionophore valinomycin , the specific mitochondrial benzodiazepine ligand PK11195 , or by primary [caspase] *activation* by cross linking . Positive_regulation CASP1 FAS 10364198 620462 EGF stimulation of epithelial cells also inhibited *induced* [caspase] activation and the proteolysis of signaling proteins downstream of the EGF receptor , Cbl and Akt/protein kinase B ( Akt ) . Positive_regulation CASP1 FAS 10391681 626711 ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , [caspase] activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation CASP1 FAS 10391681 626727 M3/6 prevented Fas stimulation of JNK , but did not affect mediated [caspase] *activation* or cell death , demonstrating that JNK activation is not required for these processes . Positive_regulation CASP1 FAS 10405325 629338 *induced* [caspase] activation and nuclear apoptosis , however , were unaffected by the depletion of ATP . Positive_regulation CASP1 FAS 10464143 640275 Suppression of *induced* activation of the [caspase] by IL-1beta was diminished by coadministration with D-galactosamine and reversed by coinjection with an excess amount of uridine . Positive_regulation CASP1 FAS 10545115 564277 Taken together , these findings argue that hDaxx promotes sensitivity to Fas from a nuclear location , probably by modulating the transcription of genes involved in *induced* [caspase] activation and apoptosis . Positive_regulation CASP1 FAS 10706558 673176 In conclusion , in vivo stimulation *causes* [caspase] activation , mitochondrial permeability transition ( decreasing the membrane potential and increasing basal respiration ) , mitochondrial matrix expansion ( as shown by matrix herniation ) , outer mitochondrial membrane rupture , and cytochrome c release . Positive_regulation CASP1 FAS 10749152 681126 These results indicate that mediated [caspase] *activation* elicits two independent cellular responses ; Positive_regulation CASP1 FAS 10766189 684357 The caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp ( OMe ) fluoromethyl ketone ( zVADfmk ) , at concentrations that completely prevent apoptosis and [caspase] activation *induced* by ligation of the death receptor , had only a partial protective effect on onconase induced cell death . Positive_regulation CASP1 FAS 11260077 796087 ligation increased apoptosis and decreased colony growth equally in RARS and controls , but *caused* significantly more [caspase] activation in RARS ( P < 0.01 ) . Positive_regulation CASP1 FAS 11278283 819061 Staurosporine activates MST either caspase-dependently or independently , whereas ligation *activates* it only [caspase-dependently] . Positive_regulation CASP1 FAS 11295536 801381 NH ( 2 ) Cl pretreatment significantly inhibited apoptosis and [caspase] activation *induced* by etoposide or camptothecin , a DNA topoisomerase I poison , but not by staurosporine or stimulation . Positive_regulation CASP1 FAS 11322649 807136 Gamma-interferon ( IFN-gamma ) augments apoptotic response to mistletoe lectin-II via upregulation of L expression and [caspase] *activation* in human myeloid U937 cells . Positive_regulation CASP1 FAS 11334117 809199 *induced* upregulation of [caspase-1] and -3 expression in the nucleus and cytoplasm in A549 cells . Positive_regulation CASP1 FAS 11359796 816296 In isolated GC B cells , cFLIP ( L ) decays rapidly even without ligation , and this *results* in activation of [caspase] activity and apoptosis . Positive_regulation CASP1 FAS 11368434 817072 *induced* [caspase] activity is increased in RARS bone marrow cells . Positive_regulation CASP1 FAS 11536010 854841 We conclude that ( i ) synergistic induction of apoptosis by C2-ceramide and CD95L depend on a cross-talk between the two signal transduction pathways and that ( ii ) C2-ceramide , independently of its sensitizing effects on dependent [caspase] *activation* , is also capable of triggering an apoptotic signaling cascade that is unaffected by zVAD-fmk mediated caspase inhibition , but promoted by high levels of CD95 expression . Positive_regulation CASP1 FAS 11551934 882146 PI3-kinase inhibition sensitized to apoptosis by increasing and accelerating mediated [caspase] *activation* . Positive_regulation CASP1 FAS 11673515 872821 Thus , *induced* initiation of [caspase] activity at the plasma membrane may in some cells result in local proteolysis of submembrane proteins , leading to generation of membrane vesicles that are highly enriched in active caspase 8 . Positive_regulation CASP1 FAS 11698497 878157 Interleukin (IL)-5 and interferon (IFN)-gamma , two cytokines known to prolong eosinophil survival , inhibited *mediated* apoptosis and [caspase] activation but poorly affected the decrease in DeltaPsi ( m ) . Positive_regulation CASP1 FAS 11699200 878327 Recent work has demonstrated that the degree of spontaneous caspase activation in FHL lymphocytes is attenuated in vitro whereas mediated [caspase] *activation* and apoptosis induction remains unmitigated , and FHL can thus be distinguished from the related chronic disorder of immune regulation termed autoimmune lymphoproliferative syndrome or ALPS . Positive_regulation CASP1 FAS 11834943 911161 Lamivudine was also found to stimulate in vitro induced apoptosis and [caspase] *activation* in pre activated T lymphocytes from healthy donors . Positive_regulation CASP1 FAS 12165276 972780 Further investigation of *mediated* [caspase] activities revealed that supplementation of glutamine significantly decreased caspase-3 and caspase-8 activities in activated T cells . Positive_regulation CASP1 FAS 12207331 983587 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Positive_regulation CASP1 FAS 12221075 998182 Enforced expression of GPx1 also resulted in inhibition of *induced* effector [caspase] activation , DNA fragmentation , and apoptotic cell death . Positive_regulation CASP1 FAS 12393561 1035686 Moreover , we have previously reported that G-CSF inhibits *induced* [caspase] activation in sideroblastic anemia ( RARS ) . Positive_regulation CASP1 FAS 12393594 1031519 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Positive_regulation CASP1 FAS 12404126 1009721 Structure-function analysis determined that ATP hydrolysis was necessary for P-gp to confer resistance to *induced* [caspase] activation and cell death . Positive_regulation CASP1 FAS 12444127 1017305 These data indicate that TCR ligation can activate nonapoptotic death programs in WT CD8 ( + ) and CD8 ( + ) T blasts that normally are masked by mediated [caspase] *activation* . Positive_regulation CASP1 FAS 12605597 1079478 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block and etoposide *induced* [caspase] activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation CASP1 FAS 12700647 1082027 Myriocin did not modulate the expression of CD95 or CD95L , instead , it interfered with the early steps of mediated [caspase] *activation* . Positive_regulation CASP1 FAS 12760867 1091395 This effect was correlated with an increase in mediated [caspase] *activation* and enhanced cleavage of the caspase substrate poly ( ADP-ribose ) polymerase . Positive_regulation CASP1 FAS 12760867 1091408 Furthermore , the positive effect on mediated [caspase] *activation* by IFN and ribavirin was confirmed by immunocytochemistry for activated caspase-3 and by immunoblot detection of activated caspase-3 , caspase-7 , and caspase-8 . Positive_regulation CASP1 FAS 12760867 1091421 IFN and ribavirin also enhance mediated [caspase] *activation* , which might in part be responsible for the apoptosis promoting effect of these antiviral compounds . Positive_regulation CASP1 FAS 12850790 1109569 Here , newly developed suicide genes , including *inducible* , inducible [caspase] and CD20 are discussed . Positive_regulation CASP1 FAS 12855571 1149816 Importantly , up-regulation of Gadd45 beta by CD40 precedes induced [caspase] *activation* , as well as up-regulation of other NF-kappa B-controlled inhibitors of apoptosis such as Bcl-xL and c-FLIPL . Positive_regulation CASP1 FAS 12938225 1133107 Co-incubation with cycloheximide partially reversed protection from apoptosis and increased *stimulated* initiator and effector [caspase] activation , suggesting new protein synthesis is necessary to induce protection upstream of caspase activation . Positive_regulation CASP1 FAS 14576776 1156535 The spontaneous death of CD4+ and CD8+ T cells was not prevented by a decoy CD95 receptor or by a broad-spectrum caspase inhibitor ( zVAD-fmk ) , suggesting that this form of cell death is independent of interaction and [caspase] *activation* . Positive_regulation CASP1 FAS 14675162 1189357 Both and anti-CD95 antibodies *triggered* [caspase] activation followed by apoptotic death in fully pro-inflammatory astrocytes , whereas resting cells were totally resistant . Positive_regulation CASP1 FAS 14690854 1194668 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , , and TRAIL receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP1 FAS 14738570 1242697 ligation significantly *increased* the activities of both [Caspase 1] and Caspase 3 at 20 hours of stimulation ( 1.7- and 2.0-fold versus control , both p < 0.05 ) ; Positive_regulation CASP1 FAS 15197350 1347070 The inhibitory activity of TPCK was found to be death ligand-specific since TPCK inhibits TRAIL mediated caspase activity but does not affect *induced* [caspase] activity . Positive_regulation CASP1 FAS 15322156 1286758 Consistent with its role in cell death induction , deletion of caspase-8 in hepatocytes protected them from induced [caspase] *activation* and death . Positive_regulation CASP1 FAS 15648737 1350014 These findings suggest that mild hypothermia suppresses mediated apoptosis of liver cells by the partial inhibition of signaling events including mitochondrial damage , cytochrome c release , and subsequent apoptosome formation and effector [caspase] *activation* . Positive_regulation CASP1 FAS 15863130 1401078 Binding of Fas ligand or agonistic anti-Fas antibody to the death receptor can *activate* a [caspase-cascade] resulting in apoptosis . Positive_regulation CASP1 FAS 16120269 895970 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Positive_regulation CASP1 FAS 16384930 1547170 JAK2 mutated PV erythroblasts showed lower levels of *induced* [caspase] activation and incomplete caspase mediated cleavage of the erythroid transcription factor GATA-1 , which was entirely degraded in normal erythroblasts on CD95 stimulation . Positive_regulation CASP1 FAS 16527894 1574400 Simultaneously , mediated [caspase] *activation* precipitates differentiation . Positive_regulation CASP1 FAS 16646028 1557176 stimulation activated NF-kappaB and AP-1 , and this response *required* [caspase] activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation CASP1 FAS 17245429 1690835 The nucleo-cytoplasmic translocation of FLASH requires induced [caspase] *activation* and is facilitated by the Crm1 dependent nuclear export pathway . Positive_regulation CASP1 FAS 17304508 1718974 These results suggest the possible involvement of multiple signaling pathways from the MAPK to the subsequent mitochondria- and/or mediated [caspase] *activation* are potential requirements for PCA induced AGS apoptosis . Positive_regulation CASP1 FAS 18386902 1907135 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , [caspase] activation , and *induction* . Positive_regulation CASP1 FAS 18593565 1953603 *induced* [caspase] activation leads to degradation of gp130 , thereby suppressing IL-6 induced phosphorylation of STAT3 ( Tyr ( 705 ) ) and of tyrosine phosphatase SHP2 ( Tyr ( 580 ) ) . Positive_regulation CASP1 FAS 18948840 2041281 All *led* to a reduced DISC formation and diminished initiator [caspase] activity upon CD95-stimulation , whereas a marked heterogeneity in sensitivity to CD95 induced killing was found . Positive_regulation CASP1 FAS 19002587 1991264 In epithelial cells , induced hierarchic [caspase] *activation* is also linked with DEDD , a member of the DED family that binds to keratin (K) intermediate filaments ( IFs ) . Positive_regulation CASP1 FAS 19111607 2031760 However , recent studies have shown that can *induce* nonapoptotic [caspase independent cell death (CICD)] when caspase activity is inhibited . Positive_regulation CASP1 FAS 19680267 2157899 CD95 is a death receptor whose stimulation by either the physiologic ligand or the agonistic antibodies *leads* to the formation of a multi-molecular complex termed DISC ( death inducing signaling complex ) and the subsequent induction of a [caspase-driven] apoptotic signal . Positive_regulation CASP1 FAS 20876774 2368745 Simultaneous downregulation of c-FLIP ( L ) and c-FLIP ( S ) as well as individual knockdown of either isoform by RNA interference significantly enhances TRAIL ( tumour necrosis factor related apoptosis inducing ligand ) - and *induced* [caspase] activation and caspase dependent apoptosis . Positive_regulation CASP1 FAS 22543586 2750624 Furthermore , loss of RAGE increased expression of the death receptor CD95 ( Fas , Apo-1 ) , *dependent* [caspase] activation and extrinsic apoptosis , whereas NF-kB-p65 nuclear translocation was diminished . Positive_regulation CASP1 FAS 23029562 2681054 Blocking the ERK pathway using a pharmacological inhibitor increased the susceptibility of 661W cells to *induced* [caspase] activation and apoptosis . Positive_regulation CASP1 FAS 23530784 2762295 Various methods to inhibit apoptosis including the cell surface receptor pathway inhibitors , [caspase] *inhibitors* , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation CASP1 FAS 24928990 2946809 Real-time detection of CTL function reveals distinct patterns of [caspase] activation *mediated* by versus granzyme B . Positive_regulation CASP1 FAS 24928990 2946837 Thus , we have used a novel , real-time assay to demonstrate the distinct pattern of [caspase] activation *induced* by granzyme B versus in human and murine CTLs . Positive_regulation CASP1 FAS 8614469 353597 These results indicate that sequentially *activates* [ICE-] and CPP32-like proteases , and that downstream CPP32 , together with a component ( s ) in the cytoplasm , causes apoptosis of nuclei . Positive_regulation CASP1 FAS 8892627 392128 To determine the relationship between ICE and its substrate IL-1beta , we examined six human cell lines for susceptibility to Fas mediated apoptosis and *induction* of [ICE-like] activity . Positive_regulation CASP1 FAS 8912630 395407 CPP32 , but not [ICE] , was activated in *response* to stimulation . Positive_regulation CASP1 FAS 9317114 456235 In A20 cells , signaling may thus *trigger* both [ICE] activation and Bcl-x and Bcl-2 down-regulation . Positive_regulation CASP1 FAS 9421482 481195 Similar effects were obtained when cells were treated with synthetic [ICE] inhibitors , which blocked apoptosis in *response* to triggering . Positive_regulation CASP1 FAS 9637489 513678 Here , we investigated whether the apoptosis occurring after TCR/CD9 stimulation is associated with a death pathway involving Fas stimulation and mediated [caspase] *activation* as observed in activation induced cell death ( AICD ) . Positive_regulation CASP1 FAS 9694885 524276 Our results demonstrate that whereas mediated activation of caspase 3 *requires* an upstream [caspase] activity that is zVAD-fmk-sensitive , the initial cleavage of caspase 3 during granule mediated cell death is insensitive to zVAD-fmk , suggesting that caspase 3 is cleaved directly by granzyme B in vivo . Positive_regulation CASP1 IL1B 10843390 700070 [Caspase-1] *activation* of and IL-18 are essential for Shigella flexneri induced inflammation . Positive_regulation CASP1 IL1B 12540519 1050542 8. This study demonstrates that injection of a selective caspase-1 inhibitor after myocardial ischaemia markedly reduced the detrimental effect conferred by hypercholesterolaemia on myocardial ischaemia-reperfusion injury by attenuating both necrotic as well as apoptotic cell death pathways through inhibition of production and *activation* of [caspase-1] and caspase-3 . Positive_regulation CASP1 IL1B 16305880 1485763 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , and interleukin-6 , and *activation* of caspase-1 , caspase-3 and [caspase-11] . Positive_regulation CASP1 IL1B 16394010 1506050 A potent adjuvant monophosphoryl lipid A triggers various immune responses , but not secretion of or *activation* of [caspase-1] . Positive_regulation CASP1 IL1B 17336692 1707645 and IL-18 are related closely , and both *require* the intracellular cysteine protease [caspase-1] for biological activity . Positive_regulation CASP1 IL1B 17404311 1721991 Aluminum hydroxide adjuvants activate [caspase-1] and *induce* and IL-18 release . Positive_regulation CASP1 IL1B 17404311 1721994 In this study , we show that Alum activates [caspase-1] and *induce* secretion of mature and IL-18 . Positive_regulation CASP1 IL1B 17459804 1731504 Secretion of the proinflammatory cytokine *requires* [caspase-1] and Toll-like receptor (TLR) signaling . Positive_regulation CASP1 IL1B 17551224 1752639 However , leptin treatment increased monocyte/macrophages production of as well as TNF-alpha , and *induced* the mRNA expression of [caspase-1] , which is shown to mediate the conversion of latent pro-IL-1beta and pro-IL-18 to active forms . Positive_regulation CASP1 IL1B 17768231 1790466 Addition of CCCP 15 min after infection blocked macrophage cell death , the *activation* of [caspase-1] and the maturation of , without affecting uptake or escape of S. flexneri from the phagosome . Positive_regulation CASP1 IL1B 18242710 1877071 Statin synergizes with LPS to *induce* release by THP-1 cells through activation of [caspase-1] . Positive_regulation CASP1 IL1B 18256184 1871782 We demonstrate here that Pseudomonas aeruginosa activates [caspase 1] and *induces* secretion in infected macrophages . Positive_regulation CASP1 IL1B 18398369 1893721 Ischemia induced increased expressions of TNF-alpha ( P < or= 0.012 ) , ( P < or= 0.017 ) , ICAM-1 ( P < or= 0.025 ) , and IL-6 ( P = 0.012 ) , and diabetes *induced* increased expression of [caspase-1] ( P < or= 0.046 ) , VCAM-1 ( P < or= 0.027 ) , ICAM-1 ( P < or= 0.016 ) , IL-1beta ( P = 0.016 ) , and IL-6 ( P = 0.041 ) . Positive_regulation CASP1 IL1B 18566365 1929590 We have recently shown that alum activates [caspase-1] and *induces* secretion of mature and IL-18 . Positive_regulation CASP1 IL1B 18684863 1973543 HMG-CoA reductase inhibition *induces* release through Rac1/PI3K/PKB dependent [caspase-1] activation . Positive_regulation CASP1 IL1B 18769497 1957339 In the inflammosome complex , NALP3 or NALP1 binds to ASC and activates [caspase-1] which *induces* . Positive_regulation CASP1 IL1B 19542372 2103778 In addition to TNF-alpha , IL-1alpha and *promoted* [caspase-1] activation via Nlrp3 in response to ATP . Positive_regulation CASP1 IL1B 19596775 2122943 Furthermore , the production of IL-18 and and [caspase-1] *activation* were induced independently of a P2X7 purinergic receptor , and the inability of DeltaRD1 in caspase-1 activation was compensated for by nigericin , an agent inducing the potassium ion efflux . Positive_regulation CASP1 IL1B 19717510 2133532 In this study , we show that the ability of Staphylococcus aureus , a leading cause of infection in humans , to activate [caspase-1] and *induce* secretion resides in culture supernatants of growing bacteria . Positive_regulation CASP1 IL1B 19737897 2186517 Bacillus anthracis capsule activates [caspase-1] and *induces* release from differentiated THP-1 and human monocyte derived dendritic cells . Positive_regulation CASP1 IL1B 19950258 2172370 [Caspase 1-independent] *activation* of in neutrophil-predominant inflammation . Positive_regulation CASP1 IL1B 20477603 1506552 and IL-18 are closely related , and both *require* the intracellular cysteine protease [caspase-1] for biologic activity . Positive_regulation CASP1 MAOA 17883400 1830017 Two unrelated inhibitors *reduced* [caspase] activation . Positive_regulation CASP1 MAP2K6 16397410 1512924 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP1 MAP2K6 16672322 1583682 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* [caspase] activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only caspase activity . Positive_regulation CASP1 MAP2K6 19494289 2091596 ASC mediated AP-1 activation was inhibited by chemical or protein inhibitors for caspase-8 , caspase-8 targeting small interfering RNA , and p38 and JNK inhibitors , but not by a [caspase-1] *inhibitor* , caspase-9 or Fas associated death domain protein ( FADD ) dominant negative mutants , FADD- or RICK targeting small interfering RNAs , or a inhibitor , indicating that the ASC induced AP-1 activation is mediated by caspase-8 , p38 , and JNK , but does not require caspase-1 , caspase-9 , FADD , RICK , or ERK . Positive_regulation CASP1 MAP2K6 21364665 2361074 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP1 MMP28 13679861 1140437 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP1 MMP7 13679861 1140452 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP1 RNASE1 15620724 1357735 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and induced [caspase] *activation* in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP1 RNASE1 15620724 1357969 We find that and RC-RNase/IFN-gamma *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP1 RNASE7 15620724 1357743 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and induced [caspase] *activation* in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP1 RNASE7 15620724 1357977 We find that and RC-RNase/IFN-gamma *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP1 SPHK1 11238741 791074 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Positive_regulation CASP1 TLR7 16982856 1617228 This work examines the role of apoptosis associated speck-like protein containing a caspase-recruitment domain (ASC) , an adaptor molecule important for mediated [caspase-1] *activation* . Positive_regulation CASP1 TLR7 18523309 1922911 P2X(7) receptors ( P2X(7)Rs ) are ATP gated ion channels that trigger [caspase-1] activation in the *presence* of ligands . Positive_regulation CASP1 TLR7 19104081 2042067 Controversy has arisen whether ligands alone can *activate* [caspase-1] for release of interleukin-1beta (IL-1beta) . Positive_regulation CASP1 TLR7 19249118 2105970 Determination of expression-levels using real-time RT-PCR showed significantly augmented *dependent* IL-1beta and [caspase-1] expression . Positive_regulation CASP1 TLR7 20632067 2367975 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in *mediated* activation of [caspase 1] and interleukin-1ß . Positive_regulation CASP1 TLR7 20632067 2368054 Specific inhibition of the XOD activity attenuates mediated *activation* of [caspase 1] and IL-1ß release . Positive_regulation CASP1 TNF 10425195 632753 *induces* [caspase] activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation CASP1 TNF 10586080 571798 Silymarin also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated *induced* cytotoxicity and [caspase] activation . Positive_regulation CASP1 TNF 10593992 572956 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Positive_regulation CASP1 TNF 10764744 698791 Addition of H ( 2 ) O ( 2 ) prevented *induced* apoptosis and [caspase] activation , an effect prevented by simultaneous addition of catalase . Positive_regulation CASP1 TNF 10820260 694385 *induced* cytotoxicity , [caspase] activation , and lipid peroxidation were also abolished by vesnarinone . Positive_regulation CASP1 TNF 10843709 700171 Resveratrol also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated *induced* cytotoxicity and [caspase] activation . Positive_regulation CASP1 TNF 11228746 581002 induced *activation* of [caspase] activity was blocked by all three types of quenchers . Positive_regulation CASP1 TNF 11397893 823859 *increased* the messenger ribonucleic acid levels of [ICE] , TNF alpha , IL-1 beta , bcl-2 , and NF kappa B in preadipocytes and adipocytes ( P < 0.01 ) . Positive_regulation CASP1 TNF 11847111 912590 mediated [caspase] *activation* and block of differentiation are dependent upon the expression of PW1 , but occur independently of NFkappaB activation . Positive_regulation CASP1 TNF 12036088 949063 *promotes* [caspase] activation and apoptosis in human fetal membranes . Positive_regulation CASP1 TNF 12080044 976100 We also showed that stable overexpression of A20 inhibits apoptosis and [caspase] activation *induced* by . Positive_regulation CASP1 TNF 12431778 1015380 Our results demonstrate that TGF-beta1 can decrease TNF-alpha induced apoptosis in murine osteoblasts at least in part by attenuating *induced* [caspase] gene expression . Positive_regulation CASP1 TNF 12663669 1092456 In the presence of cycloheximide , or interleukin-1 *initiates* [caspase] activation , loss of mitochondrial membrane potential ( DeltaPsi ) , DNA degradation , and nuclear condensation and fragmentation characteristic of apoptotic cell death in human vascular endothelial cells ( EC ) . Positive_regulation CASP1 TNF 12763364 1093887 The latter and mediated [caspase] *activation* was attenuated by prostaglandin E ( 2 ) . Positive_regulation CASP1 TNF 12800192 1098911 The antioxidants N-acetylcysteine , reduced glutathione , lipoic acid and ascorbic acid markedly reduced the enhancing effect of the hormone on *induced* [caspase] activation . Positive_regulation CASP1 TNF 12800192 1098924 The effect of calcitriol on DeltaPsi was mimicked by rotenone , which increased both the drop in DeltaPsi and [caspase] activation *induced* by . Positive_regulation CASP1 TNF 14738570 1242700 in contrast , purified *increased* the activity of Caspase 3 but not [Caspase 1] ( 2.1-fold , p < 0.05 ) . Positive_regulation CASP1 TNF 15033766 1184105 The antioxidants N-acetylcysteine , glutathione , lipoic acid , and ascorbic acid markedly reduced the effect of the hormone on *induced* [caspase] activation , attesting to the involvement of reactive oxygen species ( ROS ) in the cross-talk between the hormone and the cytokine . Positive_regulation CASP1 TNF 15283855 1277818 In the *presence* of or endotoxin ( LPS ) , blockade of CD18 ( beta2 chain ) with mAb markedly increased [caspase] activation in PMN on fibrinogen . Positive_regulation CASP1 TNF 15452110 1341970 These mutant cells exhibited a defect in induced [caspase] *activation* , Bid cleavage , and release of cytochrome c . Positive_regulation CASP1 TNF 16492401 1567744 induced a gradual *increase* in [caspase-1] and -8 mRNA levels that was not seen with IL-1beta . Positive_regulation CASP1 TNF 16532377 1555281 Inhibition of the p38 and/or the JNK death pathways reduced [caspase] activation *induced* by oxidative stress , hyperosmotic shock and . Positive_regulation CASP1 TNF 16631528 1552347 We report that DDC strongly inhibits [caspase] activation , loss of DeltaPsim , and cell death *induced* by or etoposide . Positive_regulation CASP1 TNF 16924232 1692189 *induced* the expression of NF-kappaB regulated gene products cyclin D1 , c-Myc , matrix metalloproteinase-9 , survivin , X-linked inhibitor-of-apoptosis protein ( IAP ) , IAP1 , Bcl-x ( L ) , A1/Bfl-1 and Fas associated death domain protein-like [IL-1beta converting enzyme-inhibitory] protein in wild-type MEF but not in PKR-/- cells . Positive_regulation CASP1 TNF 17047073 1635885 Importantly , down-regulation of TRAIL by small interfering RNA silencing decreased mediated Adriamycin induced [caspase] *activation* and apoptosis , and thus enhanced breast cancer cell resistance to Adriamycin . Positive_regulation CASP1 TNF 17125837 1686476 ATD5 could also reduce the TNF-alpha mediated cytotoxicity and inhibit mediated [caspase] *activation* on L929 cells in a dose dependent manner . Positive_regulation CASP1 TNF 17551224 1752638 However , leptin treatment increased monocyte/macrophages production of IL-1beta as well as , and *induced* the mRNA expression of [caspase-1] , which is shown to mediate the conversion of latent pro-IL-1beta and pro-IL-18 to active forms . Positive_regulation CASP1 TNF 17599041 1848490 We have recently shown that *induces* [caspase dependent and -independent] JNK activation and ROS accumulation in cellular FLICE-inhibitory protein ( c-Flip ) ( -/- ) murine embryonic fibroblasts ( MEFs ) . Positive_regulation CASP1 TNF 17725714 1789909 *induced* [caspase-1] gene expression . Positive_regulation CASP1 TNF 17725714 1789910 The molecular mechanisms involved in *induced* [caspase-1] gene expression remain poorly defined , despite the fact that signaling by TNF-alpha has been well studied . Positive_regulation CASP1 TNF 17725714 1789911 The present study was undertaken to investigate the mechanisms involved in the *induction* of [caspase-1] gene expression by . Positive_regulation CASP1 TNF 17725714 1789912 Mutation of the interferon regulatory factor-1 binding site resulted in the almost complete loss of basal as well as of *induced* [caspase-1] promoter activity . Positive_regulation CASP1 TNF 17725714 1789915 Our results show that TNF-alpha induces p73 gene expression , which , together with interferon regulatory factor-1 , plays an important role in mediating [caspase-1] promoter *activation* by . Positive_regulation CASP1 TNF 18023359 1832127 Mitochondrial apoptotic inducer bax , and the suppressor bcl-2 were evaluated using western blotting at 48 h. Results indicated that *increased* [caspase] activities and resulted in a significant ( p = 0.001 ) increase in bax/bcl-2 ratio . Positive_regulation CASP1 TNF 18398369 1893719 Ischemia induced increased expressions of ( P < or= 0.012 ) , IL-1beta ( P < or= 0.017 ) , ICAM-1 ( P < or= 0.025 ) , and IL-6 ( P = 0.012 ) , and diabetes *induced* increased expression of [caspase-1] ( P < or= 0.046 ) , VCAM-1 ( P < or= 0.027 ) , ICAM-1 ( P < or= 0.016 ) , IL-1beta ( P = 0.016 ) , and IL-6 ( P = 0.041 ) . Positive_regulation CASP1 TNF 18467439 1938874 However , XIAP small interfering RNA restored *induced* [caspase] signaling and apoptosis in Hec-1A cells ; Positive_regulation CASP1 TNF 19345705 2094379 Finally , reconstitution of PPT1 activity in mutant cells was accompanied by resensitization to *induced* [caspase] activation and toxicity . Positive_regulation CASP1 TNF 19440308 2078405 Muscle regeneration is , at least in part , regulated by caspase activation , and AVP abrogated *dependent* [caspase] activation . Positive_regulation CASP1 TNF 20131228 2219904 *induced* [caspase 1] activity was determined by a colorimetric assay . Positive_regulation CASP1 TNF 20200974 2299808 Silencing FOXO1 using siRNA in vitro significantly reduced *induced* apoptosis and [caspase] activity in differentiated chondrocytes . Positive_regulation CASP1 TNF 21184820 2396752 Additionally , IHT inhibited the production of interleukin (IL)-6 , IL-8 , and , as well as the *activation* of nuclear factor-?B and [caspase-1] in PMACI stimulated HMC-1 . Positive_regulation CASP1 TNF 21269505 2392742 is also *required* for appropriate regulation of [caspase] genes . Positive_regulation CASP1 TNF 21893119 2506454 Conversely , *activation* of [caspase] by exogenous required IL-13 , TWEAK , and Fn14 . Positive_regulation CASP1 TNF 24283717 2916692 In parallel , NMDA triggered the expression of NOD-like receptor protein ( NLRP3 ) , *activation* of [caspase-1] , and release of IL-1ß and in primary WT but not TKO Müller cultures . Positive_regulation CASP1 TNF 24684347 2935137 Smac-mimetic 1-induced loss of cIAPs correlated with inhibition of mediated NF-?B activation , [caspase] *activation* , and tumor cell killing . Positive_regulation CASP1 TNF 9531309 496816 Furthermore , only murine but not IL-1alphabeta *increased* [caspase] activity and apoptosis . Positive_regulation CASP1 TNF 9726961 529847 Instead , *induced* the translocation of [pro-caspase-1] to the nucleus where it was proteolytically activated , releasing the intact prodomain . Positive_regulation CASP1 TNF 9885230 584451 *induced* [caspase] activation was accompanied by a decrease in the ability of neutrophils to release superoxide anion . Positive_regulation CASP1 TNF 9885230 584477 Granulocyte-macrophage colony stimulating factor inhibited *induced* [caspase] activation and apoptosis , while reversing the diminution in superoxide release . Positive_regulation CASP1 TNFSF10 11677236 896117 Combining and interferon in vitro , synergistically *induced* apoptosis and [caspase] activation in breast cancer cells . Positive_regulation CASP1 TNFSF10 12815069 1103413 In addition , overexpression of cleavage-site mutant c-IAP1 makes cells more resistant to *induced* [caspase] activation . Positive_regulation CASP1 TNFSF10 14644092 1188253 Furthermore , the enhancement extended to *induced* [caspase-activation] . Positive_regulation CASP1 TNFSF10 14690854 1194669 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , Fas , and receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP1 TNFSF10 15197350 1347057 In this study , we show that TPCK inhibits *induced* [caspase] activity but potentiates wortmannin dependent caspase activity in prostatic carcinoma cell lines . Positive_regulation CASP1 TNFSF10 15558024 1361124 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both promoted by amiloride . Positive_regulation CASP1 TNFSF10 15569667 1368284 Here we demonstrate that human breast cancer cells , but not normal mammary epithelial cells , are dramatically sensitized to *induced* apoptosis and [caspase] activation by peroxisome proliferator activated receptor gamma ( PPARgamma ) agonists of the thiazolidinedione ( TZD ) class . Positive_regulation CASP1 TNFSF10 16103097 1444519 Generation of ROS by CCCP was responsible for *induced* Bax and [caspase] activation because scavenging ROS completely abrogated apical caspase-8 activation and further downstream events leading to cell death . Positive_regulation CASP1 TNFSF10 17031854 1700273 Here we demonstrated that human prostate cancer cells , but not normal prostate cells , are dramatically sensitized to *induced* apoptosis and [caspase] activation by quercetin . Positive_regulation CASP1 TNFSF10 17031854 1700286 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both enhanced by quercetin . Positive_regulation CASP1 TNFSF10 17545549 1751972 We isolated primary tumor cells from 13 astrocytoma and oligoastrocytoma patients of all four WHO grades of malignancy and compared the levels of *induced* apoptosis induction , long-term tumor cell survival , [caspase] , and caspase target cleavage . Positive_regulation CASP1 TNFSF10 17724141 1822418 Rituximab , a CD20 antibody used to treat certain types of NHL , augmented induced [caspase] *activation* in Ramos RA1 and DoHH2 but not BJAB or SC-1 cells , through modulation of intrinsic rather than extrinsic apoptosis signaling . Positive_regulation CASP1 TNFSF10 17804742 1791205 Although the proteolytic processing of procaspase-3 by TRAIL was partially blocked in glioma cells , cotreatment with silibinin efficiently recovered *induced* [caspase] activation in these cells . Positive_regulation CASP1 TNFSF10 18483385 1910824 Aspirin sensitized human breast cancer cells , but not untransformed human mammary epithelial cells , to induced [caspase] *activation* and apoptosis by a cyclooxygenase-2 independent mechanism . Positive_regulation CASP1 TNFSF10 18665234 1943056 Stable knockdown of bid lead to a pronounced resistance to Fas/CD95- and *induced* [caspase] activation and apoptosis , and significantly increased clonogenic survival . Positive_regulation CASP1 TNFSF10 18980244 1995219 While the proteolytic processing of procaspase-3 by TRAIL was partially blocked in various HCC cells treated with TRAIL alone , co-treatment with quercetin efficiently recovered *induced* [caspase] activation . Positive_regulation CASP1 TNFSF10 20400979 2274057 The ability of ovarian cancer ascites to activate Akt and inhibit *induced* cell death and [caspase] activity was decreased by heat inactivation , but was retained in ascites fractions > 5 kDa . Positive_regulation CASP1 TNFSF10 20400979 2274070 These results suggest that ovarian cancer ascites induces FAK and Akt activation in an alphavbeta5 integrin dependent pathway , which confers protection from *induced* cell death and [caspase] activation . Positive_regulation CASP1 TNFSF10 21109947 2366193 induced [caspase/p38] *activation* is responsible for the increased catalytic and invasive activities of Akt . Positive_regulation CASP1 TNFSF10 22991197 2734926 We demonstrate that EGFR targeted in combination with BZB *induced* significantly higher [caspase] activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation CASP1 TNFSF10 23180246 2723786 *induces* autophagic protein cleavage through [caspase] activation in melanoma cell lines under arginine deprivation . Positive_regulation CASP1 TNFSF10 24525736 2914806 Treatment of hepatoma cells with salubrinal , an inhibitor of eIF2a dephosphorylation , enhances *induced* eIF2a phosphorylation , CCAAT/enhancer binding protein homologous protein ( CHOP ) expression and [caspase] activation . Positive_regulation CASP1 TNFSF10 24525736 2914820 Moreover , knockdown of growth arrest and DNA damage-inducible protein 34 ( GADD34 ) , which recruits protein phosphatase 1 to dephosphorylate eIF2a , enhances *induced* eIF2a phosphorylation , CHOP expression , [caspase] activation and apoptosis . Positive_regulation CASP1 TNFSF10 24525736 2914834 Knockdown of CHOP abrogates the stimulation of *induced* [caspase] activation and apoptosis by salubrinal . Positive_regulation CASP10 CAPN8 11449356 836171 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Positive_regulation CASP10 CAPN8 12358768 994303 Calpain inhibitor III ( MDL-28170 ) reduced caspase activation , suggesting that [caspase] activation was *mediated* by . Positive_regulation CASP10 CAPN8 12917442 1151007 Interestingly , the overexpression of parkin induced the activation of an intracellular cysteine protease , calpain , but not [caspase] , and the cytoprotective effect of parkin on alpha-synuclein cytotoxicity was significantly *inhibited* by the presence of inhibitors . Positive_regulation CASP10 CAPN8 16597613 1604204 However , PD-150606 also attenuated caspase-3 activity and apoptosis at 24 h , suggesting *dependent* [caspase] activation . Positive_regulation CASP10 CCND1 12480939 1078942 Bcl-2 controls [caspase] activation *following* a p53 dependent death signal . Positive_regulation CASP10 EPHB2 15304372 1322266 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Positive_regulation CASP10 EPHB2 16397410 1512926 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP10 EPHB2 17192846 1701815 These effects were paralleled by disruption of Ras -- > and Akt survival pathways , consequent decreased phosphorylation of both mitochondrial bcl-2 and bad proteins , and [caspase] *activation* . Positive_regulation CASP10 EPHB2 19709398 2139128 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Positive_regulation CASP10 EPHB2 20177944 2236689 This [caspase] activation is *mediated* by phosphorylation of Akt and . Positive_regulation CASP10 EPHB2 21364665 2361076 dependent multiple [caspase] *activation* by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP10 EPHB2 22193398 2543466 Overexpression of ZnT-1 markedly reduced LDH release and caspase activation following I/R. Knockdown of endogenous ZnT-1 augmented the I/R induced release of LDH and increased [caspase] *activation* following I/R. levels were significantly increased following I/R in cells overexpressing ZnT-1 , while knockdown of ZnT-1 reduced phospho-ERK levels . Positive_regulation CASP10 EPHB2 22554503 2590590 The activation of increased XIAP expression and *led* to decreased [caspase] activation . Positive_regulation CASP10 FAS 10213689 608070 *induced* [caspase] denitrosylation . Positive_regulation CASP10 FAS 10352269 617203 In strict contrast , TPA is an ineffective inhibitor when cell death is induced by the potassium ionophore valinomycin , the specific mitochondrial benzodiazepine ligand PK11195 , or by primary [caspase] *activation* by cross linking . Positive_regulation CASP10 FAS 10364198 620463 EGF stimulation of epithelial cells also inhibited induced [caspase] *activation* and the proteolysis of signaling proteins downstream of the EGF receptor , Cbl and Akt/protein kinase B ( Akt ) . Positive_regulation CASP10 FAS 10391681 626712 ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , [caspase] activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation CASP10 FAS 10391681 626728 M3/6 prevented Fas stimulation of JNK , but did not affect mediated [caspase] *activation* or cell death , demonstrating that JNK activation is not required for these processes . Positive_regulation CASP10 FAS 10405325 629339 induced [caspase] *activation* and nuclear apoptosis , however , were unaffected by the depletion of ATP . Positive_regulation CASP10 FAS 10464143 640276 Suppression of induced *activation* of the [caspase] by IL-1beta was diminished by coadministration with D-galactosamine and reversed by coinjection with an excess amount of uridine . Positive_regulation CASP10 FAS 10545115 564278 Taken together , these findings argue that hDaxx promotes sensitivity to Fas from a nuclear location , probably by modulating the transcription of genes involved in induced [caspase] *activation* and apoptosis . Positive_regulation CASP10 FAS 10706558 673177 In conclusion , in vivo stimulation *causes* [caspase] activation , mitochondrial permeability transition ( decreasing the membrane potential and increasing basal respiration ) , mitochondrial matrix expansion ( as shown by matrix herniation ) , outer mitochondrial membrane rupture , and cytochrome c release . Positive_regulation CASP10 FAS 10749152 681127 These results indicate that mediated [caspase] *activation* elicits two independent cellular responses ; Positive_regulation CASP10 FAS 10766189 684358 The caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp ( OMe ) fluoromethyl ketone ( zVADfmk ) , at concentrations that completely prevent apoptosis and [caspase] activation *induced* by ligation of the death receptor , had only a partial protective effect on onconase induced cell death . Positive_regulation CASP10 FAS 11260077 796088 ligation increased apoptosis and decreased colony growth equally in RARS and controls , but *caused* significantly more [caspase] activation in RARS ( P < 0.01 ) . Positive_regulation CASP10 FAS 11278283 819062 Staurosporine activates MST either caspase-dependently or independently , whereas ligation *activates* it only [caspase-dependently] . Positive_regulation CASP10 FAS 11295536 801382 NH ( 2 ) Cl pretreatment significantly inhibited apoptosis and [caspase] activation *induced* by etoposide or camptothecin , a DNA topoisomerase I poison , but not by staurosporine or stimulation . Positive_regulation CASP10 FAS 11322649 807138 Gamma-interferon ( IFN-gamma ) augments apoptotic response to mistletoe lectin-II via upregulation of L expression and [caspase] *activation* in human myeloid U937 cells . Positive_regulation CASP10 FAS 11359796 816297 In isolated GC B cells , cFLIP ( L ) decays rapidly even without ligation , and this *results* in activation of [caspase] activity and apoptosis . Positive_regulation CASP10 FAS 11368434 817073 *induced* [caspase] activity is increased in RARS bone marrow cells . Positive_regulation CASP10 FAS 11536010 854842 We conclude that ( i ) synergistic induction of apoptosis by C2-ceramide and CD95L depend on a cross-talk between the two signal transduction pathways and that ( ii ) C2-ceramide , independently of its sensitizing effects on *dependent* [caspase] activation , is also capable of triggering an apoptotic signaling cascade that is unaffected by zVAD-fmk mediated caspase inhibition , but promoted by high levels of CD95 expression . Positive_regulation CASP10 FAS 11551934 882147 PI3-kinase inhibition sensitized to apoptosis by increasing and accelerating mediated [caspase] *activation* . Positive_regulation CASP10 FAS 11673515 872822 Thus , *induced* initiation of [caspase] activity at the plasma membrane may in some cells result in local proteolysis of submembrane proteins , leading to generation of membrane vesicles that are highly enriched in active caspase 8 . Positive_regulation CASP10 FAS 11698497 878158 Interleukin (IL)-5 and interferon (IFN)-gamma , two cytokines known to prolong eosinophil survival , inhibited mediated apoptosis and [caspase] *activation* but poorly affected the decrease in DeltaPsi ( m ) . Positive_regulation CASP10 FAS 11699200 878328 Recent work has demonstrated that the degree of spontaneous caspase activation in FHL lymphocytes is attenuated in vitro whereas mediated [caspase] *activation* and apoptosis induction remains unmitigated , and FHL can thus be distinguished from the related chronic disorder of immune regulation termed autoimmune lymphoproliferative syndrome or ALPS . Positive_regulation CASP10 FAS 11834943 911162 Lamivudine was also found to stimulate in vitro *induced* apoptosis and [caspase] activation in pre activated T lymphocytes from healthy donors . Positive_regulation CASP10 FAS 12165276 972781 Further investigation of *mediated* [caspase] activities revealed that supplementation of glutamine significantly decreased caspase-3 and caspase-8 activities in activated T cells . Positive_regulation CASP10 FAS 12207331 983588 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Positive_regulation CASP10 FAS 12221075 998184 Enforced expression of GPx1 also resulted in inhibition of *induced* effector [caspase] activation , DNA fragmentation , and apoptotic cell death . Positive_regulation CASP10 FAS 12393561 1035687 Moreover , we have previously reported that G-CSF inhibits induced [caspase] *activation* in sideroblastic anemia ( RARS ) . Positive_regulation CASP10 FAS 12393594 1031520 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Positive_regulation CASP10 FAS 12404126 1009722 Structure-function analysis determined that ATP hydrolysis was necessary for P-gp to confer resistance to induced [caspase] *activation* and cell death . Positive_regulation CASP10 FAS 12444127 1017306 These data indicate that TCR ligation can activate nonapoptotic death programs in WT CD8 ( + ) and CD8 ( + ) T blasts that normally are masked by mediated [caspase] *activation* . Positive_regulation CASP10 FAS 12605597 1079479 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block and etoposide *induced* [caspase] activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation CASP10 FAS 12700647 1082028 Myriocin did not modulate the expression of CD95 or CD95L , instead , it interfered with the early steps of mediated [caspase] *activation* . Positive_regulation CASP10 FAS 12760867 1091396 This effect was correlated with an increase in mediated [caspase] *activation* and enhanced cleavage of the caspase substrate poly ( ADP-ribose ) polymerase . Positive_regulation CASP10 FAS 12760867 1091409 Furthermore , the positive effect on mediated [caspase] *activation* by IFN and ribavirin was confirmed by immunocytochemistry for activated caspase-3 and by immunoblot detection of activated caspase-3 , caspase-7 , and caspase-8 . Positive_regulation CASP10 FAS 12760867 1091422 IFN and ribavirin also enhance mediated [caspase] *activation* , which might in part be responsible for the apoptosis promoting effect of these antiviral compounds . Positive_regulation CASP10 FAS 12850790 1109570 Here , newly developed suicide genes , including *inducible* , inducible [caspase] and CD20 are discussed . Positive_regulation CASP10 FAS 12855571 1149817 Importantly , up-regulation of Gadd45 beta by CD40 precedes *induced* [caspase] activation , as well as up-regulation of other NF-kappa B-controlled inhibitors of apoptosis such as Bcl-xL and c-FLIPL . Positive_regulation CASP10 FAS 12938225 1133108 Co-incubation with cycloheximide partially reversed protection from apoptosis and increased *stimulated* initiator and effector [caspase] activation , suggesting new protein synthesis is necessary to induce protection upstream of caspase activation . Positive_regulation CASP10 FAS 14576776 1156536 The spontaneous death of CD4+ and CD8+ T cells was not prevented by a decoy CD95 receptor or by a broad-spectrum caspase inhibitor ( zVAD-fmk ) , suggesting that this form of cell death is independent of interaction and [caspase] *activation* . Positive_regulation CASP10 FAS 14675162 1189358 Both and anti-CD95 antibodies *triggered* [caspase] activation followed by apoptotic death in fully pro-inflammatory astrocytes , whereas resting cells were totally resistant . Positive_regulation CASP10 FAS 14690854 1194670 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , , and TRAIL receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP10 FAS 15197350 1347071 The inhibitory activity of TPCK was found to be death ligand-specific since TPCK inhibits TRAIL mediated caspase activity but does not affect *induced* [caspase] activity . Positive_regulation CASP10 FAS 15322156 1286759 Consistent with its role in cell death induction , deletion of caspase-8 in hepatocytes protected them from *induced* [caspase] activation and death . Positive_regulation CASP10 FAS 15648737 1350015 These findings suggest that mild hypothermia suppresses *mediated* apoptosis of liver cells by the partial inhibition of signaling events including mitochondrial damage , cytochrome c release , and subsequent apoptosome formation and effector [caspase] activation . Positive_regulation CASP10 FAS 15863130 1401079 Binding of Fas ligand or agonistic anti-Fas antibody to the death receptor can *activate* a [caspase-cascade] resulting in apoptosis . Positive_regulation CASP10 FAS 16120269 895971 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Positive_regulation CASP10 FAS 16384930 1547171 JAK2 mutated PV erythroblasts showed lower levels of induced [caspase] *activation* and incomplete caspase mediated cleavage of the erythroid transcription factor GATA-1 , which was entirely degraded in normal erythroblasts on CD95 stimulation . Positive_regulation CASP10 FAS 16527894 1574401 Simultaneously , mediated [caspase] *activation* precipitates differentiation . Positive_regulation CASP10 FAS 16646028 1557180 stimulation activated NF-kappaB and AP-1 , and this response *required* [caspase] activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation CASP10 FAS 17245429 1690836 The nucleo-cytoplasmic translocation of FLASH requires *induced* [caspase] activation and is facilitated by the Crm1 dependent nuclear export pathway . Positive_regulation CASP10 FAS 17304508 1718975 These results suggest the possible involvement of multiple signaling pathways from the MAPK to the subsequent mitochondria- and/or mediated [caspase] *activation* are potential requirements for PCA induced AGS apoptosis . Positive_regulation CASP10 FAS 18386902 1907136 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , [caspase] activation , and *induction* . Positive_regulation CASP10 FAS 18593565 1953604 induced [caspase] *activation* leads to degradation of gp130 , thereby suppressing IL-6 induced phosphorylation of STAT3 ( Tyr ( 705 ) ) and of tyrosine phosphatase SHP2 ( Tyr ( 580 ) ) . Positive_regulation CASP10 FAS 18948840 2041282 All *led* to a reduced DISC formation and diminished initiator [caspase] activity upon CD95-stimulation , whereas a marked heterogeneity in sensitivity to CD95 induced killing was found . Positive_regulation CASP10 FAS 19002587 1991265 In epithelial cells , *induced* hierarchic [caspase] activation is also linked with DEDD , a member of the DED family that binds to keratin (K) intermediate filaments ( IFs ) . Positive_regulation CASP10 FAS 19111607 2031761 However , recent studies have shown that can *induce* nonapoptotic [caspase independent cell death (CICD)] when caspase activity is inhibited . Positive_regulation CASP10 FAS 19380486 2094728 Autocrine secretion of FAS ligand and upregulated expression induced by UVB irradiation *contributed* to activation of [caspase-10] , which cleaved Hsp90 beta at D278 , P293 , and D294 . Positive_regulation CASP10 FAS 19680267 2157900 CD95 is a death receptor whose stimulation by either the physiologic ligand or the agonistic antibodies *leads* to the formation of a multi-molecular complex termed DISC ( death inducing signaling complex ) and the subsequent induction of a [caspase-driven] apoptotic signal . Positive_regulation CASP10 FAS 20876774 2368746 Simultaneous downregulation of c-FLIP ( L ) and c-FLIP ( S ) as well as individual knockdown of either isoform by RNA interference significantly enhances TRAIL ( tumour necrosis factor related apoptosis inducing ligand ) - and *induced* [caspase] activation and caspase dependent apoptosis . Positive_regulation CASP10 FAS 22543586 2750625 Furthermore , loss of RAGE increased expression of the death receptor CD95 ( Fas , Apo-1 ) , dependent [caspase] *activation* and extrinsic apoptosis , whereas NF-kB-p65 nuclear translocation was diminished . Positive_regulation CASP10 FAS 23029562 2681055 Blocking the ERK pathway using a pharmacological inhibitor increased the susceptibility of 661W cells to induced [caspase] *activation* and apoptosis . Positive_regulation CASP10 FAS 23530784 2762296 Various methods to inhibit apoptosis including the cell surface receptor pathway inhibitors , [caspase] *inhibitors* , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation CASP10 FAS 24928990 2946811 Real-time detection of CTL function reveals distinct patterns of [caspase] activation *mediated* by versus granzyme B . Positive_regulation CASP10 FAS 24928990 2946839 Thus , we have used a novel , real-time assay to demonstrate the distinct pattern of [caspase] activation *induced* by granzyme B versus in human and murine CTLs . Positive_regulation CASP10 FAS 9637489 513679 Here , we investigated whether the apoptosis occurring after TCR/CD9 stimulation is associated with a death pathway involving Fas stimulation and mediated [caspase] *activation* as observed in activation induced cell death ( AICD ) . Positive_regulation CASP10 FAS 9694885 524278 Our results demonstrate that whereas mediated activation of caspase 3 *requires* an upstream [caspase] activity that is zVAD-fmk-sensitive , the initial cleavage of caspase 3 during granule mediated cell death is insensitive to zVAD-fmk , suggesting that caspase 3 is cleaved directly by granzyme B in vivo . Positive_regulation CASP10 IL1B 16305880 1485779 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , and interleukin-6 , and *activation* of caspase-1 , caspase-3 and [caspase-11] . Positive_regulation CASP10 MAOA 17883400 1830018 Two unrelated inhibitors *reduced* [caspase] activation . Positive_regulation CASP10 MAP2K6 16397410 1512932 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP10 MAP2K6 16672322 1583691 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* [caspase] activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only caspase activity . Positive_regulation CASP10 MAP2K6 21364665 2361082 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP10 MMP28 13679861 1140459 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP10 MMP7 13679861 1140474 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP10 RNASE1 15620724 1357748 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and induced [caspase] *activation* in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP10 RNASE1 15620724 1357982 We find that and RC-RNase/IFN-gamma *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP10 RNASE7 15620724 1357756 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and induced [caspase] *activation* in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP10 RNASE7 15620724 1357990 We find that and RC-RNase/IFN-gamma *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP10 SPHK1 11238741 791076 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Positive_regulation CASP10 TNF 10425195 632754 *induces* [caspase] activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation CASP10 TNF 10586080 571799 Silymarin also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated induced cytotoxicity and [caspase] *activation* . Positive_regulation CASP10 TNF 10593992 572957 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Positive_regulation CASP10 TNF 10764744 698792 Addition of H ( 2 ) O ( 2 ) prevented induced apoptosis and [caspase] *activation* , an effect prevented by simultaneous addition of catalase . Positive_regulation CASP10 TNF 10820260 694386 induced cytotoxicity , [caspase] *activation* , and lipid peroxidation were also abolished by vesnarinone . Positive_regulation CASP10 TNF 10843709 700172 Resveratrol also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated induced cytotoxicity and [caspase] *activation* . Positive_regulation CASP10 TNF 11228746 581003 induced *activation* of [caspase] activity was blocked by all three types of quenchers . Positive_regulation CASP10 TNF 11847111 912591 mediated [caspase] *activation* and block of differentiation are dependent upon the expression of PW1 , but occur independently of NFkappaB activation . Positive_regulation CASP10 TNF 12036088 949064 *promotes* [caspase] activation and apoptosis in human fetal membranes . Positive_regulation CASP10 TNF 12080044 976103 We also showed that stable overexpression of A20 inhibits apoptosis and [caspase] activation *induced* by . Positive_regulation CASP10 TNF 12431778 1015381 Our results demonstrate that TGF-beta1 can decrease TNF-alpha induced apoptosis in murine osteoblasts at least in part by attenuating *induced* [caspase] gene expression . Positive_regulation CASP10 TNF 12663669 1092484 In the presence of cycloheximide , or interleukin-1 *initiates* [caspase] activation , loss of mitochondrial membrane potential ( DeltaPsi ) , DNA degradation , and nuclear condensation and fragmentation characteristic of apoptotic cell death in human vascular endothelial cells ( EC ) . Positive_regulation CASP10 TNF 12763364 1093888 The latter and mediated [caspase] *activation* was attenuated by prostaglandin E ( 2 ) . Positive_regulation CASP10 TNF 12800192 1098912 The antioxidants N-acetylcysteine , reduced glutathione , lipoic acid and ascorbic acid markedly reduced the enhancing effect of the hormone on induced [caspase] *activation* . Positive_regulation CASP10 TNF 12800192 1098925 The effect of calcitriol on DeltaPsi was mimicked by rotenone , which increased both the drop in DeltaPsi and [caspase] activation *induced* by . Positive_regulation CASP10 TNF 14687710 1179597 Thus , these results suggest that over-expression of GRB2 and [FLICE2] in RA synovium is *caused* by inducibility differentially regulated in RA synoviocytes and provide potential pathogenic roles of these genes in the hyperplasia of the RA synovium . Positive_regulation CASP10 TNF 15033766 1184106 The antioxidants N-acetylcysteine , glutathione , lipoic acid , and ascorbic acid markedly reduced the effect of the hormone on induced [caspase] *activation* , attesting to the involvement of reactive oxygen species ( ROS ) in the cross-talk between the hormone and the cytokine . Positive_regulation CASP10 TNF 15283855 1277819 In the *presence* of or endotoxin ( LPS ) , blockade of CD18 ( beta2 chain ) with mAb markedly increased [caspase] activation in PMN on fibrinogen . Positive_regulation CASP10 TNF 15452110 1341971 These mutant cells exhibited a defect in *induced* [caspase] activation , Bid cleavage , and release of cytochrome c . Positive_regulation CASP10 TNF 16532377 1555282 Inhibition of the p38 and/or the JNK death pathways reduced [caspase] activation *induced* by oxidative stress , hyperosmotic shock and . Positive_regulation CASP10 TNF 16631528 1552348 We report that DDC strongly inhibits [caspase] activation , loss of DeltaPsim , and cell death *induced* by or etoposide . Positive_regulation CASP10 TNF 17047073 1635886 Importantly , down-regulation of TRAIL by small interfering RNA silencing decreased mediated Adriamycin induced [caspase] *activation* and apoptosis , and thus enhanced breast cancer cell resistance to Adriamycin . Positive_regulation CASP10 TNF 17125837 1686477 ATD5 could also reduce the TNF-alpha mediated cytotoxicity and inhibit mediated [caspase] *activation* on L929 cells in a dose dependent manner . Positive_regulation CASP10 TNF 17599041 1848491 We have recently shown that *induces* [caspase dependent and -independent] JNK activation and ROS accumulation in cellular FLICE-inhibitory protein ( c-Flip ) ( -/- ) murine embryonic fibroblasts ( MEFs ) . Positive_regulation CASP10 TNF 18023359 1832128 Mitochondrial apoptotic inducer bax , and the suppressor bcl-2 were evaluated using western blotting at 48 h. Results indicated that *increased* [caspase] activities and resulted in a significant ( p = 0.001 ) increase in bax/bcl-2 ratio . Positive_regulation CASP10 TNF 18467439 1938875 However , XIAP small interfering RNA restored *induced* [caspase] signaling and apoptosis in Hec-1A cells ; Positive_regulation CASP10 TNF 19345705 2094380 Finally , reconstitution of PPT1 activity in mutant cells was accompanied by resensitization to induced [caspase] *activation* and toxicity . Positive_regulation CASP10 TNF 19440308 2078406 Muscle regeneration is , at least in part , regulated by caspase activation , and AVP abrogated dependent [caspase] *activation* . Positive_regulation CASP10 TNF 20200974 2299809 Silencing FOXO1 using siRNA in vitro significantly reduced *induced* apoptosis and [caspase] activity in differentiated chondrocytes . Positive_regulation CASP10 TNF 21269505 2392743 is also *required* for appropriate regulation of [caspase] genes . Positive_regulation CASP10 TNF 21893119 2506458 Conversely , *activation* of [caspase] by exogenous required IL-13 , TWEAK , and Fn14 . Positive_regulation CASP10 TNF 24684347 2935138 Smac-mimetic 1-induced loss of cIAPs correlated with inhibition of mediated NF-?B activation , [caspase] *activation* , and tumor cell killing . Positive_regulation CASP10 TNF 9531309 496818 Furthermore , only murine but not IL-1alphabeta *increased* [caspase] activity and apoptosis . Positive_regulation CASP10 TNF 9885230 584452 induced [caspase] *activation* was accompanied by a decrease in the ability of neutrophils to release superoxide anion . Positive_regulation CASP10 TNF 9885230 584478 Granulocyte-macrophage colony stimulating factor inhibited induced [caspase] *activation* and apoptosis , while reversing the diminution in superoxide release . Positive_regulation CASP10 TNFSF10 11677236 896118 Combining and interferon in vitro , synergistically *induced* apoptosis and [caspase] activation in breast cancer cells . Positive_regulation CASP10 TNFSF10 12815069 1103414 In addition , overexpression of cleavage-site mutant c-IAP1 makes cells more resistant to induced [caspase] *activation* . Positive_regulation CASP10 TNFSF10 14644092 1188254 Furthermore , the enhancement extended to *induced* [caspase-activation] . Positive_regulation CASP10 TNFSF10 14690854 1194671 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , Fas , and receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP10 TNFSF10 15197350 1347058 In this study , we show that TPCK inhibits *induced* [caspase] activity but potentiates wortmannin dependent caspase activity in prostatic carcinoma cell lines . Positive_regulation CASP10 TNFSF10 15558024 1361125 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both promoted by amiloride . Positive_regulation CASP10 TNFSF10 15569667 1368285 Here we demonstrate that human breast cancer cells , but not normal mammary epithelial cells , are dramatically sensitized to induced apoptosis and [caspase] *activation* by peroxisome proliferator activated receptor gamma ( PPARgamma ) agonists of the thiazolidinedione ( TZD ) class . Positive_regulation CASP10 TNFSF10 15767684 1384235 Furthermore , whereas processing of caspase-10 was delayed in TNF treated cells , *triggered* a very rapid activation of [caspase-10] and -3 . Positive_regulation CASP10 TNFSF10 16103097 1444520 Generation of ROS by CCCP was responsible for *induced* Bax and [caspase] activation because scavenging ROS completely abrogated apical caspase-8 activation and further downstream events leading to cell death . Positive_regulation CASP10 TNFSF10 17031854 1700274 Here we demonstrated that human prostate cancer cells , but not normal prostate cells , are dramatically sensitized to induced apoptosis and [caspase] *activation* by quercetin . Positive_regulation CASP10 TNFSF10 17031854 1700287 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both enhanced by quercetin . Positive_regulation CASP10 TNFSF10 17545549 1751973 We isolated primary tumor cells from 13 astrocytoma and oligoastrocytoma patients of all four WHO grades of malignancy and compared the levels of *induced* apoptosis induction , long-term tumor cell survival , [caspase] , and caspase target cleavage . Positive_regulation CASP10 TNFSF10 17724141 1822419 Rituximab , a CD20 antibody used to treat certain types of NHL , augmented *induced* [caspase] activation in Ramos RA1 and DoHH2 but not BJAB or SC-1 cells , through modulation of intrinsic rather than extrinsic apoptosis signaling . Positive_regulation CASP10 TNFSF10 17804742 1791206 Although the proteolytic processing of procaspase-3 by TRAIL was partially blocked in glioma cells , cotreatment with silibinin efficiently recovered induced [caspase] *activation* in these cells . Positive_regulation CASP10 TNFSF10 18476767 1939001 Whereas *induced* apoptosis in both cell lines through activation of caspase-3 and [caspase-10] , known to link the cell death receptor pathway to the mitochondrial pathway , it triggered increased mitochondrial membrane potential change ( m ) only in HL-60/Vinc cells . Positive_regulation CASP10 TNFSF10 18483385 1910825 Aspirin sensitized human breast cancer cells , but not untransformed human mammary epithelial cells , to *induced* [caspase] activation and apoptosis by a cyclooxygenase-2 independent mechanism . Positive_regulation CASP10 TNFSF10 18665234 1943057 Stable knockdown of bid lead to a pronounced resistance to Fas/CD95- and *induced* [caspase] activation and apoptosis , and significantly increased clonogenic survival . Positive_regulation CASP10 TNFSF10 18980244 1995220 While the proteolytic processing of procaspase-3 by TRAIL was partially blocked in various HCC cells treated with TRAIL alone , co-treatment with quercetin efficiently recovered induced [caspase] *activation* . Positive_regulation CASP10 TNFSF10 20400979 2274058 The ability of ovarian cancer ascites to activate Akt and inhibit *induced* cell death and [caspase] activity was decreased by heat inactivation , but was retained in ascites fractions > 5 kDa . Positive_regulation CASP10 TNFSF10 20400979 2274071 These results suggest that ovarian cancer ascites induces FAK and Akt activation in an alphavbeta5 integrin dependent pathway , which confers protection from *induced* cell death and [caspase] activation . Positive_regulation CASP10 TNFSF10 21109947 2366194 *induced* [caspase/p38] activation is responsible for the increased catalytic and invasive activities of Akt . Positive_regulation CASP10 TNFSF10 21911414 2599284 Apoptosis induced by avian H5N1 virus in human monocyte derived macrophages involves *inducing* [caspase-10] activation . Positive_regulation CASP10 TNFSF10 21911414 2599285 Together , this study demonstrated that apoptosis in avian virus H5N1 infected MDMs was induced by *activated* [caspase-10] , resulting in the activation of Bid and the release of AIF from mitochondria . Positive_regulation CASP10 TNFSF10 22926077 2672516 [Caspase-10] , a particular TRAIL target , was *increased* in trauma patients ' T cells with concomitantly elevated plasma levels . Positive_regulation CASP10 TNFSF10 22991197 2734927 We demonstrate that EGFR targeted in combination with BZB *induced* significantly higher [caspase] activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation CASP10 TNFSF10 23180246 2723787 *induces* autophagic protein cleavage through [caspase] activation in melanoma cell lines under arginine deprivation . Positive_regulation CASP10 TNFSF10 24525736 2914807 Treatment of hepatoma cells with salubrinal , an inhibitor of eIF2a dephosphorylation , enhances induced eIF2a phosphorylation , CCAAT/enhancer binding protein homologous protein ( CHOP ) expression and [caspase] *activation* . Positive_regulation CASP10 TNFSF10 24525736 2914821 Moreover , knockdown of growth arrest and DNA damage-inducible protein 34 ( GADD34 ) , which recruits protein phosphatase 1 to dephosphorylate eIF2a , enhances induced eIF2a phosphorylation , CHOP expression , [caspase] *activation* and apoptosis . Positive_regulation CASP10 TNFSF10 24525736 2914835 Knockdown of CHOP abrogates the stimulation of induced [caspase] *activation* and apoptosis by salubrinal . Positive_regulation CASP12 CAPN8 10953012 724254 *Activation* of [caspase-12] by in apoptosis . Positive_regulation CASP12 CAPN8 10953012 724268 We propose that disturbance to intracellular calcium storage as a result of ischemic injury or amyloid beta peptide cytotoxicity may induce apoptosis through *mediated* [caspase-12] activation and Bcl-xL inactivation . Positive_regulation CASP12 CAPN8 11449356 836311 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Positive_regulation CASP12 CAPN8 12358768 994453 Calpain inhibitor III ( MDL-28170 ) reduced caspase activation , suggesting that [caspase] activation was *mediated* by . Positive_regulation CASP12 CAPN8 12917442 1151147 Interestingly , the overexpression of parkin induced the activation of an intracellular cysteine protease , calpain , but not [caspase] , and the cytoprotective effect of parkin on alpha-synuclein cytotoxicity was significantly *inhibited* by the presence of inhibitors . Positive_regulation CASP12 CAPN8 16597613 1604344 However , PD-150606 also attenuated caspase-3 activity and apoptosis at 24 h , suggesting *dependent* [caspase] activation . Positive_regulation CASP12 CAPN8 16765523 1590516 Upregulation of , a Ca2+ dependent cysteine protease , *activated* [caspase-12] that in turn caused activation of caspase-9 . Positive_regulation CASP12 CAPN8 18316105 1904247 Calpain inhibition reduced chromatin condensation and caspase-12 activity in the nucleus , suggesting that is *involved* in [caspase-12] activation and apoptosis . Positive_regulation CASP12 CAPN8 19393629 2075102 Here , we report that 1,25 ( OH ) ( 2 ) D ( 3 ) induces apoptosis in mature mouse 3T3-L1 adipocytes via activation of Ca ( 2+ ) -dependent calpain and Ca ( 2+ ) *dependent* [caspase-12] . Positive_regulation CASP12 CAPN8 19522510 2103097 This paper reports that PMFs induce apoptosis in mature mouse 3T3-L1 adipocytes via activation of Ca ( 2+ ) -dependent calpain and Ca ( 2+ ) *dependent* [caspase-12] . Positive_regulation CASP12 CAPN8 21555338 2464039 Additional studies demonstrated that deltamethrin exposure activated [caspase-12] activity and that pharmacological inhibition and siRNA knockdown of *prevented* deltamethrin induced DNA fragmentation , thus indicating a role for the endoplasmic reticulum ( ER ) stress pathway . Positive_regulation CASP12 CAPN8 22213319 2537637 This increase in [ Ca ( 2+ ) ] ( i ) is associated with activation of Ca ( 2+ ) -dependent µ-calpain and Ca ( 2+ ) *dependent* [caspase-12] . Positive_regulation CASP12 CAPN8 22487998 2601687 Furthermore , inhibition also *prevented* the activation of caspase-9 and [caspase-12] , along with the cleavage of Bid to tBid , all upstream signals for caspase-3 activation . Positive_regulation CASP12 CCND1 12480939 1078963 Bcl-2 controls [caspase] activation *following* a p53 dependent death signal . Positive_regulation CASP12 EPHB2 15304372 1322276 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Positive_regulation CASP12 EPHB2 16397410 1513006 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP12 EPHB2 17192846 1701825 These effects were paralleled by disruption of Ras -- > and Akt survival pathways , consequent decreased phosphorylation of both mitochondrial bcl-2 and bad proteins , and [caspase] *activation* . Positive_regulation CASP12 EPHB2 19709398 2139148 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Positive_regulation CASP12 EPHB2 20177944 2236729 This [caspase] activation is *mediated* by phosphorylation of Akt and . Positive_regulation CASP12 EPHB2 21364665 2361156 dependent multiple [caspase] *activation* by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP12 EPHB2 22193398 2543496 Overexpression of ZnT-1 markedly reduced LDH release and caspase activation following I/R. Knockdown of endogenous ZnT-1 augmented the I/R induced release of LDH and increased [caspase] *activation* following I/R. levels were significantly increased following I/R in cells overexpressing ZnT-1 , while knockdown of ZnT-1 reduced phospho-ERK levels . Positive_regulation CASP12 EPHB2 22554503 2590600 The activation of increased XIAP expression and *led* to decreased [caspase] activation . Positive_regulation CASP12 FAS 10213689 608080 *induced* [caspase] denitrosylation . Positive_regulation CASP12 FAS 10352269 617213 In strict contrast , TPA is an ineffective inhibitor when cell death is induced by the potassium ionophore valinomycin , the specific mitochondrial benzodiazepine ligand PK11195 , or by primary [caspase] *activation* by cross linking . Positive_regulation CASP12 FAS 10364198 620473 EGF stimulation of epithelial cells also inhibited induced [caspase] *activation* and the proteolysis of signaling proteins downstream of the EGF receptor , Cbl and Akt/protein kinase B ( Akt ) . Positive_regulation CASP12 FAS 10391681 626722 ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , [caspase] activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation CASP12 FAS 10391681 626738 M3/6 prevented Fas stimulation of JNK , but did not affect mediated [caspase] *activation* or cell death , demonstrating that JNK activation is not required for these processes . Positive_regulation CASP12 FAS 10405325 629349 induced [caspase] *activation* and nuclear apoptosis , however , were unaffected by the depletion of ATP . Positive_regulation CASP12 FAS 10464143 640286 Suppression of *induced* activation of the [caspase] by IL-1beta was diminished by coadministration with D-galactosamine and reversed by coinjection with an excess amount of uridine . Positive_regulation CASP12 FAS 10545115 564288 Taken together , these findings argue that hDaxx promotes sensitivity to Fas from a nuclear location , probably by modulating the transcription of genes involved in *induced* [caspase] activation and apoptosis . Positive_regulation CASP12 FAS 10706558 673187 In conclusion , in vivo stimulation *causes* [caspase] activation , mitochondrial permeability transition ( decreasing the membrane potential and increasing basal respiration ) , mitochondrial matrix expansion ( as shown by matrix herniation ) , outer mitochondrial membrane rupture , and cytochrome c release . Positive_regulation CASP12 FAS 10749152 681137 These results indicate that mediated [caspase] *activation* elicits two independent cellular responses ; Positive_regulation CASP12 FAS 10766189 684368 The caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp ( OMe ) fluoromethyl ketone ( zVADfmk ) , at concentrations that completely prevent apoptosis and [caspase] activation *induced* by ligation of the death receptor , had only a partial protective effect on onconase induced cell death . Positive_regulation CASP12 FAS 11260077 796098 ligation increased apoptosis and decreased colony growth equally in RARS and controls , but *caused* significantly more [caspase] activation in RARS ( P < 0.01 ) . Positive_regulation CASP12 FAS 11278283 819072 Staurosporine activates MST either caspase-dependently or independently , whereas ligation *activates* it only [caspase-dependently] . Positive_regulation CASP12 FAS 11295536 801392 NH ( 2 ) Cl pretreatment significantly inhibited apoptosis and [caspase] activation *induced* by etoposide or camptothecin , a DNA topoisomerase I poison , but not by staurosporine or stimulation . Positive_regulation CASP12 FAS 11322649 807158 Gamma-interferon ( IFN-gamma ) augments apoptotic response to mistletoe lectin-II via upregulation of L expression and [caspase] *activation* in human myeloid U937 cells . Positive_regulation CASP12 FAS 11359796 816307 In isolated GC B cells , cFLIP ( L ) decays rapidly even without ligation , and this *results* in activation of [caspase] activity and apoptosis . Positive_regulation CASP12 FAS 11368434 817083 *induced* [caspase] activity is increased in RARS bone marrow cells . Positive_regulation CASP12 FAS 11536010 854852 We conclude that ( i ) synergistic induction of apoptosis by C2-ceramide and CD95L depend on a cross-talk between the two signal transduction pathways and that ( ii ) C2-ceramide , independently of its sensitizing effects on *dependent* [caspase] activation , is also capable of triggering an apoptotic signaling cascade that is unaffected by zVAD-fmk mediated caspase inhibition , but promoted by high levels of CD95 expression . Positive_regulation CASP12 FAS 11551934 882157 PI3-kinase inhibition sensitized to apoptosis by increasing and accelerating mediated [caspase] *activation* . Positive_regulation CASP12 FAS 11673515 872832 Thus , *induced* initiation of [caspase] activity at the plasma membrane may in some cells result in local proteolysis of submembrane proteins , leading to generation of membrane vesicles that are highly enriched in active caspase 8 . Positive_regulation CASP12 FAS 11698497 878168 Interleukin (IL)-5 and interferon (IFN)-gamma , two cytokines known to prolong eosinophil survival , inhibited mediated apoptosis and [caspase] *activation* but poorly affected the decrease in DeltaPsi ( m ) . Positive_regulation CASP12 FAS 11699200 878338 Recent work has demonstrated that the degree of spontaneous caspase activation in FHL lymphocytes is attenuated in vitro whereas mediated [caspase] *activation* and apoptosis induction remains unmitigated , and FHL can thus be distinguished from the related chronic disorder of immune regulation termed autoimmune lymphoproliferative syndrome or ALPS . Positive_regulation CASP12 FAS 11834943 911172 Lamivudine was also found to stimulate in vitro *induced* apoptosis and [caspase] activation in pre activated T lymphocytes from healthy donors . Positive_regulation CASP12 FAS 12165276 972791 Further investigation of *mediated* [caspase] activities revealed that supplementation of glutamine significantly decreased caspase-3 and caspase-8 activities in activated T cells . Positive_regulation CASP12 FAS 12207331 983598 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Positive_regulation CASP12 FAS 12221075 998204 Enforced expression of GPx1 also resulted in inhibition of *induced* effector [caspase] activation , DNA fragmentation , and apoptotic cell death . Positive_regulation CASP12 FAS 12393561 1035697 Moreover , we have previously reported that G-CSF inhibits induced [caspase] *activation* in sideroblastic anemia ( RARS ) . Positive_regulation CASP12 FAS 12393594 1031530 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Positive_regulation CASP12 FAS 12404126 1009732 Structure-function analysis determined that ATP hydrolysis was necessary for P-gp to confer resistance to induced [caspase] *activation* and cell death . Positive_regulation CASP12 FAS 12444127 1017316 These data indicate that TCR ligation can activate nonapoptotic death programs in WT CD8 ( + ) and CD8 ( + ) T blasts that normally are masked by mediated [caspase] *activation* . Positive_regulation CASP12 FAS 12605597 1079489 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block and etoposide *induced* [caspase] activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation CASP12 FAS 12700647 1082038 Myriocin did not modulate the expression of CD95 or CD95L , instead , it interfered with the early steps of mediated [caspase] *activation* . Positive_regulation CASP12 FAS 12760867 1091406 This effect was correlated with an increase in mediated [caspase] *activation* and enhanced cleavage of the caspase substrate poly ( ADP-ribose ) polymerase . Positive_regulation CASP12 FAS 12760867 1091419 Furthermore , the positive effect on mediated [caspase] *activation* by IFN and ribavirin was confirmed by immunocytochemistry for activated caspase-3 and by immunoblot detection of activated caspase-3 , caspase-7 , and caspase-8 . Positive_regulation CASP12 FAS 12760867 1091432 IFN and ribavirin also enhance mediated [caspase] *activation* , which might in part be responsible for the apoptosis promoting effect of these antiviral compounds . Positive_regulation CASP12 FAS 12850790 1109580 Here , newly developed suicide genes , including *inducible* , inducible [caspase] and CD20 are discussed . Positive_regulation CASP12 FAS 12855571 1149827 Importantly , up-regulation of Gadd45 beta by CD40 precedes *induced* [caspase] activation , as well as up-regulation of other NF-kappa B-controlled inhibitors of apoptosis such as Bcl-xL and c-FLIPL . Positive_regulation CASP12 FAS 12938225 1133118 Co-incubation with cycloheximide partially reversed protection from apoptosis and increased *stimulated* initiator and effector [caspase] activation , suggesting new protein synthesis is necessary to induce protection upstream of caspase activation . Positive_regulation CASP12 FAS 14576776 1156546 The spontaneous death of CD4+ and CD8+ T cells was not prevented by a decoy CD95 receptor or by a broad-spectrum caspase inhibitor ( zVAD-fmk ) , suggesting that this form of cell death is independent of interaction and [caspase] *activation* . Positive_regulation CASP12 FAS 14675162 1189368 Both and anti-CD95 antibodies *triggered* [caspase] activation followed by apoptotic death in fully pro-inflammatory astrocytes , whereas resting cells were totally resistant . Positive_regulation CASP12 FAS 14690854 1194690 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , , and TRAIL receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP12 FAS 15197350 1347081 The inhibitory activity of TPCK was found to be death ligand-specific since TPCK inhibits TRAIL mediated caspase activity but does not affect *induced* [caspase] activity . Positive_regulation CASP12 FAS 15322156 1286769 Consistent with its role in cell death induction , deletion of caspase-8 in hepatocytes protected them from *induced* [caspase] activation and death . Positive_regulation CASP12 FAS 15648737 1350025 These findings suggest that mild hypothermia suppresses mediated apoptosis of liver cells by the partial inhibition of signaling events including mitochondrial damage , cytochrome c release , and subsequent apoptosome formation and effector [caspase] *activation* . Positive_regulation CASP12 FAS 15863130 1401089 Binding of Fas ligand or agonistic anti-Fas antibody to the death receptor can *activate* a [caspase-cascade] resulting in apoptosis . Positive_regulation CASP12 FAS 16120269 895981 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Positive_regulation CASP12 FAS 16384930 1547181 JAK2 mutated PV erythroblasts showed lower levels of induced [caspase] *activation* and incomplete caspase mediated cleavage of the erythroid transcription factor GATA-1 , which was entirely degraded in normal erythroblasts on CD95 stimulation . Positive_regulation CASP12 FAS 16527894 1574411 Simultaneously , mediated [caspase] *activation* precipitates differentiation . Positive_regulation CASP12 FAS 16646028 1557220 stimulation activated NF-kappaB and AP-1 , and this response *required* [caspase] activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation CASP12 FAS 17245429 1690846 The nucleo-cytoplasmic translocation of FLASH requires *induced* [caspase] activation and is facilitated by the Crm1 dependent nuclear export pathway . Positive_regulation CASP12 FAS 17304508 1718985 These results suggest the possible involvement of multiple signaling pathways from the MAPK to the subsequent mitochondria- and/or mediated [caspase] *activation* are potential requirements for PCA induced AGS apoptosis . Positive_regulation CASP12 FAS 18386902 1907146 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , [caspase] activation , and *induction* . Positive_regulation CASP12 FAS 18593565 1953628 induced [caspase] *activation* leads to degradation of gp130 , thereby suppressing IL-6 induced phosphorylation of STAT3 ( Tyr ( 705 ) ) and of tyrosine phosphatase SHP2 ( Tyr ( 580 ) ) . Positive_regulation CASP12 FAS 18948840 2041292 All *led* to a reduced DISC formation and diminished initiator [caspase] activity upon CD95-stimulation , whereas a marked heterogeneity in sensitivity to CD95 induced killing was found . Positive_regulation CASP12 FAS 19002587 1991275 In epithelial cells , *induced* hierarchic [caspase] activation is also linked with DEDD , a member of the DED family that binds to keratin (K) intermediate filaments ( IFs ) . Positive_regulation CASP12 FAS 19111607 2031771 However , recent studies have shown that can *induce* nonapoptotic [caspase independent cell death (CICD)] when caspase activity is inhibited . Positive_regulation CASP12 FAS 19680267 2157910 CD95 is a death receptor whose stimulation by either the physiologic ligand or the agonistic antibodies *leads* to the formation of a multi-molecular complex termed DISC ( death inducing signaling complex ) and the subsequent induction of a [caspase-driven] apoptotic signal . Positive_regulation CASP12 FAS 20876774 2368756 Simultaneous downregulation of c-FLIP ( L ) and c-FLIP ( S ) as well as individual knockdown of either isoform by RNA interference significantly enhances TRAIL ( tumour necrosis factor related apoptosis inducing ligand ) - and *induced* [caspase] activation and caspase dependent apoptosis . Positive_regulation CASP12 FAS 22543586 2750635 Furthermore , loss of RAGE increased expression of the death receptor CD95 ( Fas , Apo-1 ) , dependent [caspase] *activation* and extrinsic apoptosis , whereas NF-kB-p65 nuclear translocation was diminished . Positive_regulation CASP12 FAS 23029562 2681065 Blocking the ERK pathway using a pharmacological inhibitor increased the susceptibility of 661W cells to induced [caspase] *activation* and apoptosis . Positive_regulation CASP12 FAS 23530784 2762306 Various methods to inhibit apoptosis including the cell surface receptor pathway inhibitors , [caspase] *inhibitors* , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation CASP12 FAS 24928990 2946831 Real-time detection of CTL function reveals distinct patterns of [caspase] activation *mediated* by versus granzyme B . Positive_regulation CASP12 FAS 24928990 2946859 Thus , we have used a novel , real-time assay to demonstrate the distinct pattern of [caspase] activation *induced* by granzyme B versus in human and murine CTLs . Positive_regulation CASP12 FAS 9637489 513689 Here , we investigated whether the apoptosis occurring after TCR/CD9 stimulation is associated with a death pathway involving Fas stimulation and mediated [caspase] *activation* as observed in activation induced cell death ( AICD ) . Positive_regulation CASP12 FAS 9694885 524310 Our results demonstrate that whereas mediated activation of caspase 3 *requires* an upstream [caspase] activity that is zVAD-fmk-sensitive , the initial cleavage of caspase 3 during granule mediated cell death is insensitive to zVAD-fmk , suggesting that caspase 3 is cleaved directly by granzyme B in vivo . Positive_regulation CASP12 IL1B 16305880 1485939 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , and interleukin-6 , and *activation* of caspase-1 , caspase-3 and [caspase-11] . Positive_regulation CASP12 MAOA 17883400 1830028 Two unrelated inhibitors *reduced* [caspase] activation . Positive_regulation CASP12 MAP2K6 16397410 1513012 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP12 MAP2K6 16672322 1583781 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* [caspase] activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only caspase activity . Positive_regulation CASP12 MAP2K6 21364665 2361162 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP12 MMP28 13679861 1140679 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP12 MMP7 13679861 1140694 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP12 RNASE1 15620724 1357878 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and *induced* [caspase] activation in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP12 RNASE1 15620724 1358112 We find that RC-RNase and *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP12 RNASE7 15620724 1357886 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and *induced* [caspase] activation in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP12 RNASE7 15620724 1358120 We find that RC-RNase and *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP12 SPHK1 11238741 791096 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Positive_regulation CASP12 TNF 10425195 632764 *induces* [caspase] activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation CASP12 TNF 10586080 571809 Silymarin also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated induced cytotoxicity and [caspase] *activation* . Positive_regulation CASP12 TNF 10593992 572967 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Positive_regulation CASP12 TNF 10764744 698802 Addition of H ( 2 ) O ( 2 ) prevented *induced* apoptosis and [caspase] activation , an effect prevented by simultaneous addition of catalase . Positive_regulation CASP12 TNF 10820260 694396 *induced* cytotoxicity , [caspase] activation , and lipid peroxidation were also abolished by vesnarinone . Positive_regulation CASP12 TNF 10843709 700182 Resveratrol also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated *induced* cytotoxicity and [caspase] activation . Positive_regulation CASP12 TNF 11228746 581013 induced *activation* of [caspase] activity was blocked by all three types of quenchers . Positive_regulation CASP12 TNF 11278723 802756 *Activation* of [caspase-12] , an endoplastic reticulum ( ER ) resident caspase , through receptor associated factor 2-dependent mechanism in response to the ER stress . Positive_regulation CASP12 TNF 11847111 912601 mediated [caspase] *activation* and block of differentiation are dependent upon the expression of PW1 , but occur independently of NFkappaB activation . Positive_regulation CASP12 TNF 12036088 949074 *promotes* [caspase] activation and apoptosis in human fetal membranes . Positive_regulation CASP12 TNF 12080044 976133 We also showed that stable overexpression of A20 inhibits apoptosis and [caspase] activation *induced* by . Positive_regulation CASP12 TNF 12431778 1015391 Our results demonstrate that TGF-beta1 can decrease TNF-alpha induced apoptosis in murine osteoblasts at least in part by attenuating *induced* [caspase] gene expression . Positive_regulation CASP12 TNF 12663669 1092764 In the presence of cycloheximide , or interleukin-1 *initiates* [caspase] activation , loss of mitochondrial membrane potential ( DeltaPsi ) , DNA degradation , and nuclear condensation and fragmentation characteristic of apoptotic cell death in human vascular endothelial cells ( EC ) . Positive_regulation CASP12 TNF 12763364 1093898 The latter and mediated [caspase] *activation* was attenuated by prostaglandin E ( 2 ) . Positive_regulation CASP12 TNF 12800192 1098922 The antioxidants N-acetylcysteine , reduced glutathione , lipoic acid and ascorbic acid markedly reduced the enhancing effect of the hormone on *induced* [caspase] activation . Positive_regulation CASP12 TNF 12800192 1098935 The effect of calcitriol on DeltaPsi was mimicked by rotenone , which increased both the drop in DeltaPsi and [caspase] activation *induced* by . Positive_regulation CASP12 TNF 15033766 1184116 The antioxidants N-acetylcysteine , glutathione , lipoic acid , and ascorbic acid markedly reduced the effect of the hormone on induced [caspase] *activation* , attesting to the involvement of reactive oxygen species ( ROS ) in the cross-talk between the hormone and the cytokine . Positive_regulation CASP12 TNF 15283855 1277829 In the *presence* of or endotoxin ( LPS ) , blockade of CD18 ( beta2 chain ) with mAb markedly increased [caspase] activation in PMN on fibrinogen . Positive_regulation CASP12 TNF 15452110 1341981 These mutant cells exhibited a defect in *induced* [caspase] activation , Bid cleavage , and release of cytochrome c . Positive_regulation CASP12 TNF 16532377 1555292 Inhibition of the p38 and/or the JNK death pathways reduced [caspase] activation *induced* by oxidative stress , hyperosmotic shock and . Positive_regulation CASP12 TNF 16631528 1552358 We report that DDC strongly inhibits [caspase] activation , loss of DeltaPsim , and cell death *induced* by or etoposide . Positive_regulation CASP12 TNF 16729970 1570512 [Caspase-12] , but not caspase-9 , was activated in *response* to , indicating that an endoplasmic reticulum ( ER ) /calcium dependent pathway may be involved . Positive_regulation CASP12 TNF 17047073 1635896 Importantly , down-regulation of TRAIL by small interfering RNA silencing decreased mediated Adriamycin induced [caspase] *activation* and apoptosis , and thus enhanced breast cancer cell resistance to Adriamycin . Positive_regulation CASP12 TNF 17125837 1686487 ATD5 could also reduce the TNF-alpha mediated cytotoxicity and inhibit mediated [caspase] *activation* on L929 cells in a dose dependent manner . Positive_regulation CASP12 TNF 17599041 1848501 We have recently shown that *induces* [caspase dependent and -independent] JNK activation and ROS accumulation in cellular FLICE-inhibitory protein ( c-Flip ) ( -/- ) murine embryonic fibroblasts ( MEFs ) . Positive_regulation CASP12 TNF 18023359 1832138 Mitochondrial apoptotic inducer bax , and the suppressor bcl-2 were evaluated using western blotting at 48 h. Results indicated that *increased* [caspase] activities and resulted in a significant ( p = 0.001 ) increase in bax/bcl-2 ratio . Positive_regulation CASP12 TNF 18467439 1938885 However , XIAP small interfering RNA restored *induced* [caspase] signaling and apoptosis in Hec-1A cells ; Positive_regulation CASP12 TNF 18635549 1960076 Evidence is presented that can *stimulate* [caspase-4 and -12] activation in ethanol exposed cells , which cleaves SREBP-1 to a transcriptionally active form to induce the synthesis of lipogenic enzymes and triglycerides . Positive_regulation CASP12 TNF 19345705 2094390 Finally , reconstitution of PPT1 activity in mutant cells was accompanied by resensitization to induced [caspase] *activation* and toxicity . Positive_regulation CASP12 TNF 19440308 2078416 Muscle regeneration is , at least in part , regulated by caspase activation , and AVP abrogated dependent [caspase] *activation* . Positive_regulation CASP12 TNF 20200974 2299819 Silencing FOXO1 using siRNA in vitro significantly reduced *induced* apoptosis and [caspase] activity in differentiated chondrocytes . Positive_regulation CASP12 TNF 21269505 2392753 is also *required* for appropriate regulation of [caspase] genes . Positive_regulation CASP12 TNF 21893119 2506512 Conversely , *activation* of [caspase] by exogenous required IL-13 , TWEAK , and Fn14 . Positive_regulation CASP12 TNF 24684347 2935148 Smac-mimetic 1-induced loss of cIAPs correlated with inhibition of mediated NF-?B activation , [caspase] *activation* , and tumor cell killing . Positive_regulation CASP12 TNF 9531309 496838 Furthermore , only murine but not IL-1alphabeta *increased* [caspase] activity and apoptosis . Positive_regulation CASP12 TNF 9885230 584462 induced [caspase] *activation* was accompanied by a decrease in the ability of neutrophils to release superoxide anion . Positive_regulation CASP12 TNF 9885230 584488 Granulocyte-macrophage colony stimulating factor inhibited induced [caspase] *activation* and apoptosis , while reversing the diminution in superoxide release . Positive_regulation CASP12 TNFSF10 11677236 896128 Combining and interferon in vitro , synergistically *induced* apoptosis and [caspase] activation in breast cancer cells . Positive_regulation CASP12 TNFSF10 12815069 1103424 In addition , overexpression of cleavage-site mutant c-IAP1 makes cells more resistant to induced [caspase] *activation* . Positive_regulation CASP12 TNFSF10 14644092 1188264 Furthermore , the enhancement extended to *induced* [caspase-activation] . Positive_regulation CASP12 TNFSF10 14690854 1194691 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , Fas , and receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP12 TNFSF10 15197350 1347068 In this study , we show that TPCK inhibits *induced* [caspase] activity but potentiates wortmannin dependent caspase activity in prostatic carcinoma cell lines . Positive_regulation CASP12 TNFSF10 15558024 1361135 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both promoted by amiloride . Positive_regulation CASP12 TNFSF10 15569667 1368295 Here we demonstrate that human breast cancer cells , but not normal mammary epithelial cells , are dramatically sensitized to induced apoptosis and [caspase] *activation* by peroxisome proliferator activated receptor gamma ( PPARgamma ) agonists of the thiazolidinedione ( TZD ) class . Positive_regulation CASP12 TNFSF10 16103097 1444530 Generation of ROS by CCCP was responsible for *induced* Bax and [caspase] activation because scavenging ROS completely abrogated apical caspase-8 activation and further downstream events leading to cell death . Positive_regulation CASP12 TNFSF10 17031854 1700284 Here we demonstrated that human prostate cancer cells , but not normal prostate cells , are dramatically sensitized to *induced* apoptosis and [caspase] activation by quercetin . Positive_regulation CASP12 TNFSF10 17031854 1700297 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both enhanced by quercetin . Positive_regulation CASP12 TNFSF10 17545549 1751983 We isolated primary tumor cells from 13 astrocytoma and oligoastrocytoma patients of all four WHO grades of malignancy and compared the levels of *induced* apoptosis induction , long-term tumor cell survival , [caspase] , and caspase target cleavage . Positive_regulation CASP12 TNFSF10 17724141 1822429 Rituximab , a CD20 antibody used to treat certain types of NHL , augmented induced [caspase] *activation* in Ramos RA1 and DoHH2 but not BJAB or SC-1 cells , through modulation of intrinsic rather than extrinsic apoptosis signaling . Positive_regulation CASP12 TNFSF10 17804742 1791216 Although the proteolytic processing of procaspase-3 by TRAIL was partially blocked in glioma cells , cotreatment with silibinin efficiently recovered induced [caspase] *activation* in these cells . Positive_regulation CASP12 TNFSF10 18483385 1910835 Aspirin sensitized human breast cancer cells , but not untransformed human mammary epithelial cells , to induced [caspase] *activation* and apoptosis by a cyclooxygenase-2 independent mechanism . Positive_regulation CASP12 TNFSF10 18665234 1943067 Stable knockdown of bid lead to a pronounced resistance to Fas/CD95- and *induced* [caspase] activation and apoptosis , and significantly increased clonogenic survival . Positive_regulation CASP12 TNFSF10 18980244 1995230 While the proteolytic processing of procaspase-3 by TRAIL was partially blocked in various HCC cells treated with TRAIL alone , co-treatment with quercetin efficiently recovered *induced* [caspase] activation . Positive_regulation CASP12 TNFSF10 20400979 2274068 The ability of ovarian cancer ascites to activate Akt and inhibit *induced* cell death and [caspase] activity was decreased by heat inactivation , but was retained in ascites fractions > 5 kDa . Positive_regulation CASP12 TNFSF10 20400979 2274081 These results suggest that ovarian cancer ascites induces FAK and Akt activation in an alphavbeta5 integrin dependent pathway , which confers protection from induced cell death and [caspase] *activation* . Positive_regulation CASP12 TNFSF10 21109947 2366204 induced [caspase/p38] *activation* is responsible for the increased catalytic and invasive activities of Akt . Positive_regulation CASP12 TNFSF10 22991197 2734937 We demonstrate that EGFR targeted in combination with BZB *induced* significantly higher [caspase] activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation CASP12 TNFSF10 23180246 2723797 *induces* autophagic protein cleavage through [caspase] activation in melanoma cell lines under arginine deprivation . Positive_regulation CASP12 TNFSF10 24525736 2914817 Treatment of hepatoma cells with salubrinal , an inhibitor of eIF2a dephosphorylation , enhances induced eIF2a phosphorylation , CCAAT/enhancer binding protein homologous protein ( CHOP ) expression and [caspase] *activation* . Positive_regulation CASP12 TNFSF10 24525736 2914831 Moreover , knockdown of growth arrest and DNA damage-inducible protein 34 ( GADD34 ) , which recruits protein phosphatase 1 to dephosphorylate eIF2a , enhances *induced* eIF2a phosphorylation , CHOP expression , [caspase] activation and apoptosis . Positive_regulation CASP12 TNFSF10 24525736 2914845 Knockdown of CHOP abrogates the stimulation of induced [caspase] *activation* and apoptosis by salubrinal . Positive_regulation CASP14 CAPN8 11449356 836185 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Positive_regulation CASP14 CAPN8 12358768 994318 Calpain inhibitor III ( MDL-28170 ) reduced caspase activation , suggesting that [caspase] activation was *mediated* by . Positive_regulation CASP14 CAPN8 12917442 1151021 Interestingly , the overexpression of parkin induced the activation of an intracellular cysteine protease , calpain , but not [caspase] , and the cytoprotective effect of parkin on alpha-synuclein cytotoxicity was significantly *inhibited* by the presence of inhibitors . Positive_regulation CASP14 CAPN8 16597613 1604218 However , PD-150606 also attenuated caspase-3 activity and apoptosis at 24 h , suggesting *dependent* [caspase] activation . Positive_regulation CASP14 CCND1 12480939 1078944 Bcl-2 controls [caspase] activation *following* a p53 dependent death signal . Positive_regulation CASP14 EPHB2 15304372 1322267 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Positive_regulation CASP14 EPHB2 16397410 1512934 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP14 EPHB2 17192846 1701816 These effects were paralleled by disruption of Ras -- > and Akt survival pathways , consequent decreased phosphorylation of both mitochondrial bcl-2 and bad proteins , and [caspase] *activation* . Positive_regulation CASP14 EPHB2 19709398 2139130 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Positive_regulation CASP14 EPHB2 20177944 2236693 This [caspase] activation is *mediated* by phosphorylation of Akt and . Positive_regulation CASP14 EPHB2 21364665 2361084 dependent multiple [caspase] *activation* by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP14 EPHB2 22193398 2543469 Overexpression of ZnT-1 markedly reduced LDH release and caspase activation following I/R. Knockdown of endogenous ZnT-1 augmented the I/R induced release of LDH and increased [caspase] *activation* following I/R. levels were significantly increased following I/R in cells overexpressing ZnT-1 , while knockdown of ZnT-1 reduced phospho-ERK levels . Positive_regulation CASP14 EPHB2 22554503 2590591 The activation of increased XIAP expression and *led* to decreased [caspase] activation . Positive_regulation CASP14 FAS 10213689 608071 *induced* [caspase] denitrosylation . Positive_regulation CASP14 FAS 10352269 617204 In strict contrast , TPA is an ineffective inhibitor when cell death is induced by the potassium ionophore valinomycin , the specific mitochondrial benzodiazepine ligand PK11195 , or by primary [caspase] *activation* by cross linking . Positive_regulation CASP14 FAS 10364198 620464 EGF stimulation of epithelial cells also inhibited *induced* [caspase] activation and the proteolysis of signaling proteins downstream of the EGF receptor , Cbl and Akt/protein kinase B ( Akt ) . Positive_regulation CASP14 FAS 10391681 626713 ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , [caspase] activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation CASP14 FAS 10391681 626729 M3/6 prevented Fas stimulation of JNK , but did not affect mediated [caspase] *activation* or cell death , demonstrating that JNK activation is not required for these processes . Positive_regulation CASP14 FAS 10405325 629340 *induced* [caspase] activation and nuclear apoptosis , however , were unaffected by the depletion of ATP . Positive_regulation CASP14 FAS 10464143 640277 Suppression of *induced* activation of the [caspase] by IL-1beta was diminished by coadministration with D-galactosamine and reversed by coinjection with an excess amount of uridine . Positive_regulation CASP14 FAS 10545115 564279 Taken together , these findings argue that hDaxx promotes sensitivity to Fas from a nuclear location , probably by modulating the transcription of genes involved in *induced* [caspase] activation and apoptosis . Positive_regulation CASP14 FAS 10706558 673178 In conclusion , in vivo stimulation *causes* [caspase] activation , mitochondrial permeability transition ( decreasing the membrane potential and increasing basal respiration ) , mitochondrial matrix expansion ( as shown by matrix herniation ) , outer mitochondrial membrane rupture , and cytochrome c release . Positive_regulation CASP14 FAS 10749152 681128 These results indicate that mediated [caspase] *activation* elicits two independent cellular responses ; Positive_regulation CASP14 FAS 10766189 684359 The caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp ( OMe ) fluoromethyl ketone ( zVADfmk ) , at concentrations that completely prevent apoptosis and [caspase] activation *induced* by ligation of the death receptor , had only a partial protective effect on onconase induced cell death . Positive_regulation CASP14 FAS 11260077 796089 ligation increased apoptosis and decreased colony growth equally in RARS and controls , but *caused* significantly more [caspase] activation in RARS ( P < 0.01 ) . Positive_regulation CASP14 FAS 11278283 819063 Staurosporine activates MST either caspase-dependently or independently , whereas ligation *activates* it only [caspase-dependently] . Positive_regulation CASP14 FAS 11295536 801383 NH ( 2 ) Cl pretreatment significantly inhibited apoptosis and [caspase] activation *induced* by etoposide or camptothecin , a DNA topoisomerase I poison , but not by staurosporine or stimulation . Positive_regulation CASP14 FAS 11322649 807140 Gamma-interferon ( IFN-gamma ) augments apoptotic response to mistletoe lectin-II via upregulation of L expression and [caspase] *activation* in human myeloid U937 cells . Positive_regulation CASP14 FAS 11359796 816298 In isolated GC B cells , cFLIP ( L ) decays rapidly even without ligation , and this *results* in activation of [caspase] activity and apoptosis . Positive_regulation CASP14 FAS 11368434 817074 *induced* [caspase] activity is increased in RARS bone marrow cells . Positive_regulation CASP14 FAS 11536010 854843 We conclude that ( i ) synergistic induction of apoptosis by C2-ceramide and CD95L depend on a cross-talk between the two signal transduction pathways and that ( ii ) C2-ceramide , independently of its sensitizing effects on *dependent* [caspase] activation , is also capable of triggering an apoptotic signaling cascade that is unaffected by zVAD-fmk mediated caspase inhibition , but promoted by high levels of CD95 expression . Positive_regulation CASP14 FAS 11551934 882148 PI3-kinase inhibition sensitized to apoptosis by increasing and accelerating mediated [caspase] *activation* . Positive_regulation CASP14 FAS 11673515 872823 Thus , *induced* initiation of [caspase] activity at the plasma membrane may in some cells result in local proteolysis of submembrane proteins , leading to generation of membrane vesicles that are highly enriched in active caspase 8 . Positive_regulation CASP14 FAS 11698497 878159 Interleukin (IL)-5 and interferon (IFN)-gamma , two cytokines known to prolong eosinophil survival , inhibited *mediated* apoptosis and [caspase] activation but poorly affected the decrease in DeltaPsi ( m ) . Positive_regulation CASP14 FAS 11699200 878329 Recent work has demonstrated that the degree of spontaneous caspase activation in FHL lymphocytes is attenuated in vitro whereas mediated [caspase] *activation* and apoptosis induction remains unmitigated , and FHL can thus be distinguished from the related chronic disorder of immune regulation termed autoimmune lymphoproliferative syndrome or ALPS . Positive_regulation CASP14 FAS 11834943 911163 Lamivudine was also found to stimulate in vitro induced apoptosis and [caspase] *activation* in pre activated T lymphocytes from healthy donors . Positive_regulation CASP14 FAS 12165276 972782 Further investigation of *mediated* [caspase] activities revealed that supplementation of glutamine significantly decreased caspase-3 and caspase-8 activities in activated T cells . Positive_regulation CASP14 FAS 12207331 983589 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Positive_regulation CASP14 FAS 12221075 998186 Enforced expression of GPx1 also resulted in inhibition of induced effector [caspase] *activation* , DNA fragmentation , and apoptotic cell death . Positive_regulation CASP14 FAS 12393561 1035688 Moreover , we have previously reported that G-CSF inhibits *induced* [caspase] activation in sideroblastic anemia ( RARS ) . Positive_regulation CASP14 FAS 12393594 1031521 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Positive_regulation CASP14 FAS 12404126 1009723 Structure-function analysis determined that ATP hydrolysis was necessary for P-gp to confer resistance to *induced* [caspase] activation and cell death . Positive_regulation CASP14 FAS 12444127 1017307 These data indicate that TCR ligation can activate nonapoptotic death programs in WT CD8 ( + ) and CD8 ( + ) T blasts that normally are masked by mediated [caspase] *activation* . Positive_regulation CASP14 FAS 12605597 1079480 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block and etoposide *induced* [caspase] activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation CASP14 FAS 12700647 1082029 Myriocin did not modulate the expression of CD95 or CD95L , instead , it interfered with the early steps of mediated [caspase] *activation* . Positive_regulation CASP14 FAS 12760867 1091397 This effect was correlated with an increase in mediated [caspase] *activation* and enhanced cleavage of the caspase substrate poly ( ADP-ribose ) polymerase . Positive_regulation CASP14 FAS 12760867 1091410 Furthermore , the positive effect on mediated [caspase] *activation* by IFN and ribavirin was confirmed by immunocytochemistry for activated caspase-3 and by immunoblot detection of activated caspase-3 , caspase-7 , and caspase-8 . Positive_regulation CASP14 FAS 12760867 1091423 IFN and ribavirin also enhance mediated [caspase] *activation* , which might in part be responsible for the apoptosis promoting effect of these antiviral compounds . Positive_regulation CASP14 FAS 12850790 1109571 Here , newly developed suicide genes , including *inducible* , inducible [caspase] and CD20 are discussed . Positive_regulation CASP14 FAS 12855571 1149818 Importantly , up-regulation of Gadd45 beta by CD40 precedes induced [caspase] *activation* , as well as up-regulation of other NF-kappa B-controlled inhibitors of apoptosis such as Bcl-xL and c-FLIPL . Positive_regulation CASP14 FAS 12938225 1133109 Co-incubation with cycloheximide partially reversed protection from apoptosis and increased *stimulated* initiator and effector [caspase] activation , suggesting new protein synthesis is necessary to induce protection upstream of caspase activation . Positive_regulation CASP14 FAS 14576776 1156537 The spontaneous death of CD4+ and CD8+ T cells was not prevented by a decoy CD95 receptor or by a broad-spectrum caspase inhibitor ( zVAD-fmk ) , suggesting that this form of cell death is independent of interaction and [caspase] *activation* . Positive_regulation CASP14 FAS 14675162 1189359 Both and anti-CD95 antibodies *triggered* [caspase] activation followed by apoptotic death in fully pro-inflammatory astrocytes , whereas resting cells were totally resistant . Positive_regulation CASP14 FAS 14690854 1194672 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , , and TRAIL receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP14 FAS 15197350 1347072 The inhibitory activity of TPCK was found to be death ligand-specific since TPCK inhibits TRAIL mediated caspase activity but does not affect *induced* [caspase] activity . Positive_regulation CASP14 FAS 15322156 1286760 Consistent with its role in cell death induction , deletion of caspase-8 in hepatocytes protected them from induced [caspase] *activation* and death . Positive_regulation CASP14 FAS 15648737 1350016 These findings suggest that mild hypothermia suppresses mediated apoptosis of liver cells by the partial inhibition of signaling events including mitochondrial damage , cytochrome c release , and subsequent apoptosome formation and effector [caspase] *activation* . Positive_regulation CASP14 FAS 15863130 1401080 Binding of Fas ligand or agonistic anti-Fas antibody to the death receptor can *activate* a [caspase-cascade] resulting in apoptosis . Positive_regulation CASP14 FAS 16120269 895972 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Positive_regulation CASP14 FAS 16384930 1547172 JAK2 mutated PV erythroblasts showed lower levels of *induced* [caspase] activation and incomplete caspase mediated cleavage of the erythroid transcription factor GATA-1 , which was entirely degraded in normal erythroblasts on CD95 stimulation . Positive_regulation CASP14 FAS 16527894 1574402 Simultaneously , mediated [caspase] *activation* precipitates differentiation . Positive_regulation CASP14 FAS 16646028 1557184 stimulation activated NF-kappaB and AP-1 , and this response *required* [caspase] activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation CASP14 FAS 17245429 1690837 The nucleo-cytoplasmic translocation of FLASH requires induced [caspase] *activation* and is facilitated by the Crm1 dependent nuclear export pathway . Positive_regulation CASP14 FAS 17304508 1718976 These results suggest the possible involvement of multiple signaling pathways from the MAPK to the subsequent mitochondria- and/or mediated [caspase] *activation* are potential requirements for PCA induced AGS apoptosis . Positive_regulation CASP14 FAS 18386902 1907137 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , [caspase] activation , and *induction* . Positive_regulation CASP14 FAS 18593565 1953605 *induced* [caspase] activation leads to degradation of gp130 , thereby suppressing IL-6 induced phosphorylation of STAT3 ( Tyr ( 705 ) ) and of tyrosine phosphatase SHP2 ( Tyr ( 580 ) ) . Positive_regulation CASP14 FAS 18948840 2041283 All *led* to a reduced DISC formation and diminished initiator [caspase] activity upon CD95-stimulation , whereas a marked heterogeneity in sensitivity to CD95 induced killing was found . Positive_regulation CASP14 FAS 19002587 1991266 In epithelial cells , induced hierarchic [caspase] *activation* is also linked with DEDD , a member of the DED family that binds to keratin (K) intermediate filaments ( IFs ) . Positive_regulation CASP14 FAS 19111607 2031762 However , recent studies have shown that can *induce* nonapoptotic [caspase independent cell death (CICD)] when caspase activity is inhibited . Positive_regulation CASP14 FAS 19680267 2157901 CD95 is a death receptor whose stimulation by either the physiologic ligand or the agonistic antibodies *leads* to the formation of a multi-molecular complex termed DISC ( death inducing signaling complex ) and the subsequent induction of a [caspase-driven] apoptotic signal . Positive_regulation CASP14 FAS 20876774 2368747 Simultaneous downregulation of c-FLIP ( L ) and c-FLIP ( S ) as well as individual knockdown of either isoform by RNA interference significantly enhances TRAIL ( tumour necrosis factor related apoptosis inducing ligand ) - and *induced* [caspase] activation and caspase dependent apoptosis . Positive_regulation CASP14 FAS 22543586 2750626 Furthermore , loss of RAGE increased expression of the death receptor CD95 ( Fas , Apo-1 ) , *dependent* [caspase] activation and extrinsic apoptosis , whereas NF-kB-p65 nuclear translocation was diminished . Positive_regulation CASP14 FAS 23029562 2681056 Blocking the ERK pathway using a pharmacological inhibitor increased the susceptibility of 661W cells to *induced* [caspase] activation and apoptosis . Positive_regulation CASP14 FAS 23530784 2762297 Various methods to inhibit apoptosis including the cell surface receptor pathway inhibitors , [caspase] *inhibitors* , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation CASP14 FAS 24928990 2946813 Real-time detection of CTL function reveals distinct patterns of [caspase] activation *mediated* by versus granzyme B . Positive_regulation CASP14 FAS 24928990 2946841 Thus , we have used a novel , real-time assay to demonstrate the distinct pattern of [caspase] activation *induced* by granzyme B versus in human and murine CTLs . Positive_regulation CASP14 FAS 9637489 513680 Here , we investigated whether the apoptosis occurring after TCR/CD9 stimulation is associated with a death pathway involving Fas stimulation and mediated [caspase] *activation* as observed in activation induced cell death ( AICD ) . Positive_regulation CASP14 FAS 9694885 524280 Our results demonstrate that whereas mediated activation of caspase 3 *requires* an upstream [caspase] activity that is zVAD-fmk-sensitive , the initial cleavage of caspase 3 during granule mediated cell death is insensitive to zVAD-fmk , suggesting that caspase 3 is cleaved directly by granzyme B in vivo . Positive_regulation CASP14 IL1B 16305880 1485795 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , and interleukin-6 , and *activation* of caspase-1 , caspase-3 and [caspase-11] . Positive_regulation CASP14 MAOA 17883400 1830019 Two unrelated inhibitors *reduced* [caspase] activation . Positive_regulation CASP14 MAP2K6 16397410 1512940 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP14 MAP2K6 16672322 1583700 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* [caspase] activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only caspase activity . Positive_regulation CASP14 MAP2K6 21364665 2361090 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP14 MMP28 13679861 1140481 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP14 MMP7 13679861 1140496 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP14 RNASE1 15620724 1357761 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and induced [caspase] *activation* in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP14 RNASE1 15620724 1357995 We find that and RC-RNase/IFN-gamma *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP14 RNASE7 15620724 1357769 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and induced [caspase] *activation* in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP14 RNASE7 15620724 1358003 We find that and RC-RNase/IFN-gamma *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP14 SPHK1 11238741 791078 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Positive_regulation CASP14 TNF 10425195 632755 *induces* [caspase] activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation CASP14 TNF 10586080 571800 Silymarin also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated *induced* cytotoxicity and [caspase] activation . Positive_regulation CASP14 TNF 10593992 572958 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Positive_regulation CASP14 TNF 10764744 698793 Addition of H ( 2 ) O ( 2 ) prevented *induced* apoptosis and [caspase] activation , an effect prevented by simultaneous addition of catalase . Positive_regulation CASP14 TNF 10820260 694387 *induced* cytotoxicity , [caspase] activation , and lipid peroxidation were also abolished by vesnarinone . Positive_regulation CASP14 TNF 10843709 700173 Resveratrol also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated *induced* cytotoxicity and [caspase] activation . Positive_regulation CASP14 TNF 11228746 581004 induced *activation* of [caspase] activity was blocked by all three types of quenchers . Positive_regulation CASP14 TNF 11847111 912592 mediated [caspase] *activation* and block of differentiation are dependent upon the expression of PW1 , but occur independently of NFkappaB activation . Positive_regulation CASP14 TNF 12036088 949065 *promotes* [caspase] activation and apoptosis in human fetal membranes . Positive_regulation CASP14 TNF 12080044 976106 We also showed that stable overexpression of A20 inhibits apoptosis and [caspase] activation *induced* by . Positive_regulation CASP14 TNF 12431778 1015382 Our results demonstrate that TGF-beta1 can decrease TNF-alpha induced apoptosis in murine osteoblasts at least in part by attenuating *induced* [caspase] gene expression . Positive_regulation CASP14 TNF 12663669 1092512 In the presence of cycloheximide , or interleukin-1 *initiates* [caspase] activation , loss of mitochondrial membrane potential ( DeltaPsi ) , DNA degradation , and nuclear condensation and fragmentation characteristic of apoptotic cell death in human vascular endothelial cells ( EC ) . Positive_regulation CASP14 TNF 12763364 1093889 The latter and mediated [caspase] *activation* was attenuated by prostaglandin E ( 2 ) . Positive_regulation CASP14 TNF 12800192 1098913 The antioxidants N-acetylcysteine , reduced glutathione , lipoic acid and ascorbic acid markedly reduced the enhancing effect of the hormone on *induced* [caspase] activation . Positive_regulation CASP14 TNF 12800192 1098926 The effect of calcitriol on DeltaPsi was mimicked by rotenone , which increased both the drop in DeltaPsi and [caspase] activation *induced* by . Positive_regulation CASP14 TNF 15033766 1184107 The antioxidants N-acetylcysteine , glutathione , lipoic acid , and ascorbic acid markedly reduced the effect of the hormone on *induced* [caspase] activation , attesting to the involvement of reactive oxygen species ( ROS ) in the cross-talk between the hormone and the cytokine . Positive_regulation CASP14 TNF 15283855 1277820 In the *presence* of or endotoxin ( LPS ) , blockade of CD18 ( beta2 chain ) with mAb markedly increased [caspase] activation in PMN on fibrinogen . Positive_regulation CASP14 TNF 15452110 1341972 These mutant cells exhibited a defect in induced [caspase] *activation* , Bid cleavage , and release of cytochrome c . Positive_regulation CASP14 TNF 16532377 1555283 Inhibition of the p38 and/or the JNK death pathways reduced [caspase] activation *induced* by oxidative stress , hyperosmotic shock and . Positive_regulation CASP14 TNF 16631528 1552349 We report that DDC strongly inhibits [caspase] activation , loss of DeltaPsim , and cell death *induced* by or etoposide . Positive_regulation CASP14 TNF 17047073 1635887 Importantly , down-regulation of TRAIL by small interfering RNA silencing decreased mediated Adriamycin induced [caspase] *activation* and apoptosis , and thus enhanced breast cancer cell resistance to Adriamycin . Positive_regulation CASP14 TNF 17125837 1686478 ATD5 could also reduce the TNF-alpha mediated cytotoxicity and inhibit mediated [caspase] *activation* on L929 cells in a dose dependent manner . Positive_regulation CASP14 TNF 17599041 1848492 We have recently shown that *induces* [caspase dependent and -independent] JNK activation and ROS accumulation in cellular FLICE-inhibitory protein ( c-Flip ) ( -/- ) murine embryonic fibroblasts ( MEFs ) . Positive_regulation CASP14 TNF 18023359 1832129 Mitochondrial apoptotic inducer bax , and the suppressor bcl-2 were evaluated using western blotting at 48 h. Results indicated that *increased* [caspase] activities and resulted in a significant ( p = 0.001 ) increase in bax/bcl-2 ratio . Positive_regulation CASP14 TNF 18467439 1938876 However , XIAP small interfering RNA restored *induced* [caspase] signaling and apoptosis in Hec-1A cells ; Positive_regulation CASP14 TNF 19345705 2094381 Finally , reconstitution of PPT1 activity in mutant cells was accompanied by resensitization to *induced* [caspase] activation and toxicity . Positive_regulation CASP14 TNF 19440308 2078407 Muscle regeneration is , at least in part , regulated by caspase activation , and AVP abrogated dependent [caspase] *activation* . Positive_regulation CASP14 TNF 20200974 2299810 Silencing FOXO1 using siRNA in vitro significantly reduced *induced* apoptosis and [caspase] activity in differentiated chondrocytes . Positive_regulation CASP14 TNF 21269505 2392744 is also *required* for appropriate regulation of [caspase] genes . Positive_regulation CASP14 TNF 21893119 2506462 Conversely , *activation* of [caspase] by exogenous required IL-13 , TWEAK , and Fn14 . Positive_regulation CASP14 TNF 24684347 2935139 Smac-mimetic 1-induced loss of cIAPs correlated with inhibition of mediated NF-?B activation , [caspase] *activation* , and tumor cell killing . Positive_regulation CASP14 TNF 9531309 496820 Furthermore , only murine but not IL-1alphabeta *increased* [caspase] activity and apoptosis . Positive_regulation CASP14 TNF 9885230 584453 *induced* [caspase] activation was accompanied by a decrease in the ability of neutrophils to release superoxide anion . Positive_regulation CASP14 TNF 9885230 584479 Granulocyte-macrophage colony stimulating factor inhibited *induced* [caspase] activation and apoptosis , while reversing the diminution in superoxide release . Positive_regulation CASP14 TNFSF10 11677236 896119 Combining and interferon in vitro , synergistically *induced* apoptosis and [caspase] activation in breast cancer cells . Positive_regulation CASP14 TNFSF10 12815069 1103415 In addition , overexpression of cleavage-site mutant c-IAP1 makes cells more resistant to *induced* [caspase] activation . Positive_regulation CASP14 TNFSF10 14644092 1188255 Furthermore , the enhancement extended to *induced* [caspase-activation] . Positive_regulation CASP14 TNFSF10 14690854 1194673 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , Fas , and receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP14 TNFSF10 15197350 1347059 In this study , we show that TPCK inhibits *induced* [caspase] activity but potentiates wortmannin dependent caspase activity in prostatic carcinoma cell lines . Positive_regulation CASP14 TNFSF10 15558024 1361126 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both promoted by amiloride . Positive_regulation CASP14 TNFSF10 15569667 1368286 Here we demonstrate that human breast cancer cells , but not normal mammary epithelial cells , are dramatically sensitized to *induced* apoptosis and [caspase] activation by peroxisome proliferator activated receptor gamma ( PPARgamma ) agonists of the thiazolidinedione ( TZD ) class . Positive_regulation CASP14 TNFSF10 16103097 1444521 Generation of ROS by CCCP was responsible for *induced* Bax and [caspase] activation because scavenging ROS completely abrogated apical caspase-8 activation and further downstream events leading to cell death . Positive_regulation CASP14 TNFSF10 17031854 1700275 Here we demonstrated that human prostate cancer cells , but not normal prostate cells , are dramatically sensitized to *induced* apoptosis and [caspase] activation by quercetin . Positive_regulation CASP14 TNFSF10 17031854 1700288 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both enhanced by quercetin . Positive_regulation CASP14 TNFSF10 17545549 1751974 We isolated primary tumor cells from 13 astrocytoma and oligoastrocytoma patients of all four WHO grades of malignancy and compared the levels of *induced* apoptosis induction , long-term tumor cell survival , [caspase] , and caspase target cleavage . Positive_regulation CASP14 TNFSF10 17724141 1822420 Rituximab , a CD20 antibody used to treat certain types of NHL , augmented induced [caspase] *activation* in Ramos RA1 and DoHH2 but not BJAB or SC-1 cells , through modulation of intrinsic rather than extrinsic apoptosis signaling . Positive_regulation CASP14 TNFSF10 17804742 1791207 Although the proteolytic processing of procaspase-3 by TRAIL was partially blocked in glioma cells , cotreatment with silibinin efficiently recovered *induced* [caspase] activation in these cells . Positive_regulation CASP14 TNFSF10 18483385 1910826 Aspirin sensitized human breast cancer cells , but not untransformed human mammary epithelial cells , to induced [caspase] *activation* and apoptosis by a cyclooxygenase-2 independent mechanism . Positive_regulation CASP14 TNFSF10 18665234 1943058 Stable knockdown of bid lead to a pronounced resistance to Fas/CD95- and *induced* [caspase] activation and apoptosis , and significantly increased clonogenic survival . Positive_regulation CASP14 TNFSF10 18980244 1995221 While the proteolytic processing of procaspase-3 by TRAIL was partially blocked in various HCC cells treated with TRAIL alone , co-treatment with quercetin efficiently recovered *induced* [caspase] activation . Positive_regulation CASP14 TNFSF10 20400979 2274059 The ability of ovarian cancer ascites to activate Akt and inhibit *induced* cell death and [caspase] activity was decreased by heat inactivation , but was retained in ascites fractions > 5 kDa . Positive_regulation CASP14 TNFSF10 20400979 2274072 These results suggest that ovarian cancer ascites induces FAK and Akt activation in an alphavbeta5 integrin dependent pathway , which confers protection from induced cell death and [caspase] *activation* . Positive_regulation CASP14 TNFSF10 21109947 2366195 induced [caspase/p38] *activation* is responsible for the increased catalytic and invasive activities of Akt . Positive_regulation CASP14 TNFSF10 22991197 2734928 We demonstrate that EGFR targeted in combination with BZB *induced* significantly higher [caspase] activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation CASP14 TNFSF10 23180246 2723788 *induces* autophagic protein cleavage through [caspase] activation in melanoma cell lines under arginine deprivation . Positive_regulation CASP14 TNFSF10 24525736 2914808 Treatment of hepatoma cells with salubrinal , an inhibitor of eIF2a dephosphorylation , enhances *induced* eIF2a phosphorylation , CCAAT/enhancer binding protein homologous protein ( CHOP ) expression and [caspase] activation . Positive_regulation CASP14 TNFSF10 24525736 2914822 Moreover , knockdown of growth arrest and DNA damage-inducible protein 34 ( GADD34 ) , which recruits protein phosphatase 1 to dephosphorylate eIF2a , enhances *induced* eIF2a phosphorylation , CHOP expression , [caspase] activation and apoptosis . Positive_regulation CASP14 TNFSF10 24525736 2914836 Knockdown of CHOP abrogates the stimulation of *induced* [caspase] activation and apoptosis by salubrinal . Positive_regulation CASP16 CAPN8 11449356 836325 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Positive_regulation CASP16 CAPN8 12358768 994468 Calpain inhibitor III ( MDL-28170 ) reduced caspase activation , suggesting that [caspase] activation was *mediated* by . Positive_regulation CASP16 CAPN8 12917442 1151161 Interestingly , the overexpression of parkin induced the activation of an intracellular cysteine protease , calpain , but not [caspase] , and the cytoprotective effect of parkin on alpha-synuclein cytotoxicity was significantly *inhibited* by the presence of inhibitors . Positive_regulation CASP16 CAPN8 16597613 1604358 However , PD-150606 also attenuated caspase-3 activity and apoptosis at 24 h , suggesting *dependent* [caspase] activation . Positive_regulation CASP16 CCND1 12480939 1078965 Bcl-2 controls [caspase] activation *following* a p53 dependent death signal . Positive_regulation CASP16 EPHB2 15304372 1322277 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Positive_regulation CASP16 EPHB2 16397410 1513014 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP16 EPHB2 17192846 1701826 These effects were paralleled by disruption of Ras -- > and Akt survival pathways , consequent decreased phosphorylation of both mitochondrial bcl-2 and bad proteins , and [caspase] *activation* . Positive_regulation CASP16 EPHB2 19709398 2139150 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Positive_regulation CASP16 EPHB2 20177944 2236733 This [caspase] activation is *mediated* by phosphorylation of Akt and . Positive_regulation CASP16 EPHB2 21364665 2361164 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP16 EPHB2 22193398 2543499 Overexpression of ZnT-1 markedly reduced LDH release and caspase activation following I/R. Knockdown of endogenous ZnT-1 augmented the I/R induced release of LDH and increased [caspase] *activation* following I/R. levels were significantly increased following I/R in cells overexpressing ZnT-1 , while knockdown of ZnT-1 reduced phospho-ERK levels . Positive_regulation CASP16 EPHB2 22554503 2590601 The activation of increased XIAP expression and *led* to decreased [caspase] activation . Positive_regulation CASP16 FAS 10213689 608081 *induced* [caspase] denitrosylation . Positive_regulation CASP16 FAS 10352269 617214 In strict contrast , TPA is an ineffective inhibitor when cell death is induced by the potassium ionophore valinomycin , the specific mitochondrial benzodiazepine ligand PK11195 , or by primary [caspase] *activation* by cross linking . Positive_regulation CASP16 FAS 10364198 620474 EGF stimulation of epithelial cells also inhibited *induced* [caspase] activation and the proteolysis of signaling proteins downstream of the EGF receptor , Cbl and Akt/protein kinase B ( Akt ) . Positive_regulation CASP16 FAS 10391681 626724 ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , [caspase] activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation CASP16 FAS 10391681 626739 M3/6 prevented Fas stimulation of JNK , but did not affect mediated [caspase] *activation* or cell death , demonstrating that JNK activation is not required for these processes . Positive_regulation CASP16 FAS 10405325 629350 *induced* [caspase] activation and nuclear apoptosis , however , were unaffected by the depletion of ATP . Positive_regulation CASP16 FAS 10464143 640287 Suppression of induced *activation* of the [caspase] by IL-1beta was diminished by coadministration with D-galactosamine and reversed by coinjection with an excess amount of uridine . Positive_regulation CASP16 FAS 10545115 564289 Taken together , these findings argue that hDaxx promotes sensitivity to Fas from a nuclear location , probably by modulating the transcription of genes involved in *induced* [caspase] activation and apoptosis . Positive_regulation CASP16 FAS 10706558 673189 In conclusion , in vivo stimulation *causes* [caspase] activation , mitochondrial permeability transition ( decreasing the membrane potential and increasing basal respiration ) , mitochondrial matrix expansion ( as shown by matrix herniation ) , outer mitochondrial membrane rupture , and cytochrome c release . Positive_regulation CASP16 FAS 10749152 681138 These results indicate that mediated [caspase] *activation* elicits two independent cellular responses ; Positive_regulation CASP16 FAS 10766189 684369 The caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp ( OMe ) fluoromethyl ketone ( zVADfmk ) , at concentrations that completely prevent apoptosis and [caspase] activation *induced* by ligation of the death receptor , had only a partial protective effect on onconase induced cell death . Positive_regulation CASP16 FAS 11260077 796099 ligation increased apoptosis and decreased colony growth equally in RARS and controls , but *caused* significantly more [caspase] activation in RARS ( P < 0.01 ) . Positive_regulation CASP16 FAS 11278283 819073 Staurosporine activates MST either caspase-dependently or independently , whereas ligation *activates* it only [caspase-dependently] . Positive_regulation CASP16 FAS 11295536 801393 NH ( 2 ) Cl pretreatment significantly inhibited apoptosis and [caspase] activation *induced* by etoposide or camptothecin , a DNA topoisomerase I poison , but not by staurosporine or stimulation . Positive_regulation CASP16 FAS 11322649 807160 Gamma-interferon ( IFN-gamma ) augments apoptotic response to mistletoe lectin-II via upregulation of L expression and [caspase] *activation* in human myeloid U937 cells . Positive_regulation CASP16 FAS 11359796 816308 In isolated GC B cells , cFLIP ( L ) decays rapidly even without ligation , and this *results* in activation of [caspase] activity and apoptosis . Positive_regulation CASP16 FAS 11368434 817084 *induced* [caspase] activity is increased in RARS bone marrow cells . Positive_regulation CASP16 FAS 11536010 854853 We conclude that ( i ) synergistic induction of apoptosis by C2-ceramide and CD95L depend on a cross-talk between the two signal transduction pathways and that ( ii ) C2-ceramide , independently of its sensitizing effects on dependent [caspase] *activation* , is also capable of triggering an apoptotic signaling cascade that is unaffected by zVAD-fmk mediated caspase inhibition , but promoted by high levels of CD95 expression . Positive_regulation CASP16 FAS 11551934 882158 PI3-kinase inhibition sensitized to apoptosis by increasing and accelerating mediated [caspase] *activation* . Positive_regulation CASP16 FAS 11673515 872833 Thus , *induced* initiation of [caspase] activity at the plasma membrane may in some cells result in local proteolysis of submembrane proteins , leading to generation of membrane vesicles that are highly enriched in active caspase 8 . Positive_regulation CASP16 FAS 11698497 878169 Interleukin (IL)-5 and interferon (IFN)-gamma , two cytokines known to prolong eosinophil survival , inhibited *mediated* apoptosis and [caspase] activation but poorly affected the decrease in DeltaPsi ( m ) . Positive_regulation CASP16 FAS 11699200 878339 Recent work has demonstrated that the degree of spontaneous caspase activation in FHL lymphocytes is attenuated in vitro whereas mediated [caspase] *activation* and apoptosis induction remains unmitigated , and FHL can thus be distinguished from the related chronic disorder of immune regulation termed autoimmune lymphoproliferative syndrome or ALPS . Positive_regulation CASP16 FAS 11834943 911173 Lamivudine was also found to stimulate in vitro induced apoptosis and [caspase] *activation* in pre activated T lymphocytes from healthy donors . Positive_regulation CASP16 FAS 12165276 972792 Further investigation of *mediated* [caspase] activities revealed that supplementation of glutamine significantly decreased caspase-3 and caspase-8 activities in activated T cells . Positive_regulation CASP16 FAS 12207331 983599 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Positive_regulation CASP16 FAS 12221075 998206 Enforced expression of GPx1 also resulted in inhibition of induced effector [caspase] *activation* , DNA fragmentation , and apoptotic cell death . Positive_regulation CASP16 FAS 12393561 1035698 Moreover , we have previously reported that G-CSF inhibits *induced* [caspase] activation in sideroblastic anemia ( RARS ) . Positive_regulation CASP16 FAS 12393594 1031531 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Positive_regulation CASP16 FAS 12404126 1009733 Structure-function analysis determined that ATP hydrolysis was necessary for P-gp to confer resistance to *induced* [caspase] activation and cell death . Positive_regulation CASP16 FAS 12444127 1017317 These data indicate that TCR ligation can activate nonapoptotic death programs in WT CD8 ( + ) and CD8 ( + ) T blasts that normally are masked by mediated [caspase] *activation* . Positive_regulation CASP16 FAS 12605597 1079491 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block and etoposide *induced* [caspase] activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation CASP16 FAS 12700647 1082039 Myriocin did not modulate the expression of CD95 or CD95L , instead , it interfered with the early steps of mediated [caspase] *activation* . Positive_regulation CASP16 FAS 12760867 1091407 This effect was correlated with an increase in mediated [caspase] *activation* and enhanced cleavage of the caspase substrate poly ( ADP-ribose ) polymerase . Positive_regulation CASP16 FAS 12760867 1091420 Furthermore , the positive effect on mediated [caspase] *activation* by IFN and ribavirin was confirmed by immunocytochemistry for activated caspase-3 and by immunoblot detection of activated caspase-3 , caspase-7 , and caspase-8 . Positive_regulation CASP16 FAS 12760867 1091433 IFN and ribavirin also enhance mediated [caspase] *activation* , which might in part be responsible for the apoptosis promoting effect of these antiviral compounds . Positive_regulation CASP16 FAS 12850790 1109581 Here , newly developed suicide genes , including *inducible* , inducible [caspase] and CD20 are discussed . Positive_regulation CASP16 FAS 12855571 1149828 Importantly , up-regulation of Gadd45 beta by CD40 precedes induced [caspase] *activation* , as well as up-regulation of other NF-kappa B-controlled inhibitors of apoptosis such as Bcl-xL and c-FLIPL . Positive_regulation CASP16 FAS 12938225 1133119 Co-incubation with cycloheximide partially reversed protection from apoptosis and increased *stimulated* initiator and effector [caspase] activation , suggesting new protein synthesis is necessary to induce protection upstream of caspase activation . Positive_regulation CASP16 FAS 14576776 1156547 The spontaneous death of CD4+ and CD8+ T cells was not prevented by a decoy CD95 receptor or by a broad-spectrum caspase inhibitor ( zVAD-fmk ) , suggesting that this form of cell death is independent of interaction and [caspase] *activation* . Positive_regulation CASP16 FAS 14675162 1189369 Both and anti-CD95 antibodies *triggered* [caspase] activation followed by apoptotic death in fully pro-inflammatory astrocytes , whereas resting cells were totally resistant . Positive_regulation CASP16 FAS 14690854 1194692 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , , and TRAIL receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP16 FAS 15197350 1347082 The inhibitory activity of TPCK was found to be death ligand-specific since TPCK inhibits TRAIL mediated caspase activity but does not affect *induced* [caspase] activity . Positive_regulation CASP16 FAS 15322156 1286770 Consistent with its role in cell death induction , deletion of caspase-8 in hepatocytes protected them from induced [caspase] *activation* and death . Positive_regulation CASP16 FAS 15648737 1350026 These findings suggest that mild hypothermia suppresses *mediated* apoptosis of liver cells by the partial inhibition of signaling events including mitochondrial damage , cytochrome c release , and subsequent apoptosome formation and effector [caspase] activation . Positive_regulation CASP16 FAS 15863130 1401090 Binding of Fas ligand or agonistic anti-Fas antibody to the death receptor can *activate* a [caspase-cascade] resulting in apoptosis . Positive_regulation CASP16 FAS 16120269 895982 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Positive_regulation CASP16 FAS 16384930 1547182 JAK2 mutated PV erythroblasts showed lower levels of *induced* [caspase] activation and incomplete caspase mediated cleavage of the erythroid transcription factor GATA-1 , which was entirely degraded in normal erythroblasts on CD95 stimulation . Positive_regulation CASP16 FAS 16527894 1574412 Simultaneously , mediated [caspase] *activation* precipitates differentiation . Positive_regulation CASP16 FAS 16646028 1557224 stimulation activated NF-kappaB and AP-1 , and this response *required* [caspase] activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation CASP16 FAS 17245429 1690847 The nucleo-cytoplasmic translocation of FLASH requires induced [caspase] *activation* and is facilitated by the Crm1 dependent nuclear export pathway . Positive_regulation CASP16 FAS 17304508 1718986 These results suggest the possible involvement of multiple signaling pathways from the MAPK to the subsequent mitochondria- and/or mediated [caspase] *activation* are potential requirements for PCA induced AGS apoptosis . Positive_regulation CASP16 FAS 18386902 1907147 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , [caspase] activation , and *induction* . Positive_regulation CASP16 FAS 18593565 1953629 *induced* [caspase] activation leads to degradation of gp130 , thereby suppressing IL-6 induced phosphorylation of STAT3 ( Tyr ( 705 ) ) and of tyrosine phosphatase SHP2 ( Tyr ( 580 ) ) . Positive_regulation CASP16 FAS 18948840 2041293 All *led* to a reduced DISC formation and diminished initiator [caspase] activity upon CD95-stimulation , whereas a marked heterogeneity in sensitivity to CD95 induced killing was found . Positive_regulation CASP16 FAS 19002587 1991276 In epithelial cells , induced hierarchic [caspase] *activation* is also linked with DEDD , a member of the DED family that binds to keratin (K) intermediate filaments ( IFs ) . Positive_regulation CASP16 FAS 19111607 2031772 However , recent studies have shown that can *induce* nonapoptotic [caspase independent cell death (CICD)] when caspase activity is inhibited . Positive_regulation CASP16 FAS 19680267 2157911 CD95 is a death receptor whose stimulation by either the physiologic ligand or the agonistic antibodies *leads* to the formation of a multi-molecular complex termed DISC ( death inducing signaling complex ) and the subsequent induction of a [caspase-driven] apoptotic signal . Positive_regulation CASP16 FAS 20876774 2368757 Simultaneous downregulation of c-FLIP ( L ) and c-FLIP ( S ) as well as individual knockdown of either isoform by RNA interference significantly enhances TRAIL ( tumour necrosis factor related apoptosis inducing ligand ) - and *induced* [caspase] activation and caspase dependent apoptosis . Positive_regulation CASP16 FAS 22543586 2750636 Furthermore , loss of RAGE increased expression of the death receptor CD95 ( Fas , Apo-1 ) , *dependent* [caspase] activation and extrinsic apoptosis , whereas NF-kB-p65 nuclear translocation was diminished . Positive_regulation CASP16 FAS 23029562 2681066 Blocking the ERK pathway using a pharmacological inhibitor increased the susceptibility of 661W cells to *induced* [caspase] activation and apoptosis . Positive_regulation CASP16 FAS 23530784 2762307 Various methods to inhibit apoptosis including the cell surface receptor pathway inhibitors , [caspase] *inhibitors* , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation CASP16 FAS 24928990 2946833 Real-time detection of CTL function reveals distinct patterns of [caspase] activation *mediated* by versus granzyme B . Positive_regulation CASP16 FAS 24928990 2946861 Thus , we have used a novel , real-time assay to demonstrate the distinct pattern of [caspase] activation *induced* by granzyme B versus in human and murine CTLs . Positive_regulation CASP16 FAS 9637489 513690 Here , we investigated whether the apoptosis occurring after TCR/CD9 stimulation is associated with a death pathway involving Fas stimulation and mediated [caspase] *activation* as observed in activation induced cell death ( AICD ) . Positive_regulation CASP16 FAS 9694885 524312 Our results demonstrate that whereas mediated activation of caspase 3 *requires* an upstream [caspase] activity that is zVAD-fmk-sensitive , the initial cleavage of caspase 3 during granule mediated cell death is insensitive to zVAD-fmk , suggesting that caspase 3 is cleaved directly by granzyme B in vivo . Positive_regulation CASP16 IL1B 16305880 1485968 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , and interleukin-6 , and *activation* of caspase-1 , caspase-3 and [caspase-11] . Positive_regulation CASP16 MAOA 17883400 1830029 Two unrelated inhibitors *reduced* [caspase] activation . Positive_regulation CASP16 MAP2K6 16397410 1513020 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP16 MAP2K6 16672322 1583790 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* [caspase] activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only caspase activity . Positive_regulation CASP16 MAP2K6 21364665 2361170 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP16 MMP28 13679861 1140701 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP16 MMP7 13679861 1140716 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP16 RNASE1 15620724 1357891 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and *induced* [caspase] activation in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP16 RNASE1 15620724 1358216 We find that and RC-RNase/IFN-gamma *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP16 RNASE7 15620724 1357899 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and *induced* [caspase] activation in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP16 RNASE7 15620724 1358224 We find that and RC-RNase/IFN-gamma *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP16 SPHK1 11238741 791098 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Positive_regulation CASP16 TNF 10425195 632765 *induces* [caspase] activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation CASP16 TNF 10586080 571810 Silymarin also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated *induced* cytotoxicity and [caspase] activation . Positive_regulation CASP16 TNF 10593992 572968 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Positive_regulation CASP16 TNF 10764744 698803 Addition of H ( 2 ) O ( 2 ) prevented induced apoptosis and [caspase] *activation* , an effect prevented by simultaneous addition of catalase . Positive_regulation CASP16 TNF 10820260 694397 induced cytotoxicity , [caspase] *activation* , and lipid peroxidation were also abolished by vesnarinone . Positive_regulation CASP16 TNF 10843709 700183 Resveratrol also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated *induced* cytotoxicity and [caspase] activation . Positive_regulation CASP16 TNF 11228746 581014 induced *activation* of [caspase] activity was blocked by all three types of quenchers . Positive_regulation CASP16 TNF 11847111 912602 mediated [caspase] *activation* and block of differentiation are dependent upon the expression of PW1 , but occur independently of NFkappaB activation . Positive_regulation CASP16 TNF 12036088 949075 *promotes* [caspase] activation and apoptosis in human fetal membranes . Positive_regulation CASP16 TNF 12080044 976136 We also showed that stable overexpression of A20 inhibits apoptosis and [caspase] activation *induced* by . Positive_regulation CASP16 TNF 12431778 1015392 Our results demonstrate that TGF-beta1 can decrease TNF-alpha induced apoptosis in murine osteoblasts at least in part by attenuating *induced* [caspase] gene expression . Positive_regulation CASP16 TNF 12663669 1092792 In the presence of cycloheximide , or interleukin-1 *initiates* [caspase] activation , loss of mitochondrial membrane potential ( DeltaPsi ) , DNA degradation , and nuclear condensation and fragmentation characteristic of apoptotic cell death in human vascular endothelial cells ( EC ) . Positive_regulation CASP16 TNF 12763364 1093899 The latter and mediated [caspase] *activation* was attenuated by prostaglandin E ( 2 ) . Positive_regulation CASP16 TNF 12800192 1098923 The antioxidants N-acetylcysteine , reduced glutathione , lipoic acid and ascorbic acid markedly reduced the enhancing effect of the hormone on induced [caspase] *activation* . Positive_regulation CASP16 TNF 12800192 1098936 The effect of calcitriol on DeltaPsi was mimicked by rotenone , which increased both the drop in DeltaPsi and [caspase] activation *induced* by . Positive_regulation CASP16 TNF 15033766 1184117 The antioxidants N-acetylcysteine , glutathione , lipoic acid , and ascorbic acid markedly reduced the effect of the hormone on *induced* [caspase] activation , attesting to the involvement of reactive oxygen species ( ROS ) in the cross-talk between the hormone and the cytokine . Positive_regulation CASP16 TNF 15283855 1277830 In the *presence* of or endotoxin ( LPS ) , blockade of CD18 ( beta2 chain ) with mAb markedly increased [caspase] activation in PMN on fibrinogen . Positive_regulation CASP16 TNF 15452110 1341983 These mutant cells exhibited a defect in *induced* [caspase] activation , Bid cleavage , and release of cytochrome c . Positive_regulation CASP16 TNF 16532377 1555293 Inhibition of the p38 and/or the JNK death pathways reduced [caspase] activation *induced* by oxidative stress , hyperosmotic shock and . Positive_regulation CASP16 TNF 16631528 1552359 We report that DDC strongly inhibits [caspase] activation , loss of DeltaPsim , and cell death *induced* by or etoposide . Positive_regulation CASP16 TNF 17047073 1635897 Importantly , down-regulation of TRAIL by small interfering RNA silencing decreased mediated Adriamycin induced [caspase] *activation* and apoptosis , and thus enhanced breast cancer cell resistance to Adriamycin . Positive_regulation CASP16 TNF 17125837 1686488 ATD5 could also reduce the TNF-alpha mediated cytotoxicity and inhibit mediated [caspase] *activation* on L929 cells in a dose dependent manner . Positive_regulation CASP16 TNF 17599041 1848502 We have recently shown that *induces* [caspase dependent and -independent] JNK activation and ROS accumulation in cellular FLICE-inhibitory protein ( c-Flip ) ( -/- ) murine embryonic fibroblasts ( MEFs ) . Positive_regulation CASP16 TNF 18023359 1832139 Mitochondrial apoptotic inducer bax , and the suppressor bcl-2 were evaluated using western blotting at 48 h. Results indicated that *increased* [caspase] activities and resulted in a significant ( p = 0.001 ) increase in bax/bcl-2 ratio . Positive_regulation CASP16 TNF 18467439 1938886 However , XIAP small interfering RNA restored *induced* [caspase] signaling and apoptosis in Hec-1A cells ; Positive_regulation CASP16 TNF 19345705 2094391 Finally , reconstitution of PPT1 activity in mutant cells was accompanied by resensitization to *induced* [caspase] activation and toxicity . Positive_regulation CASP16 TNF 19440308 2078417 Muscle regeneration is , at least in part , regulated by caspase activation , and AVP abrogated *dependent* [caspase] activation . Positive_regulation CASP16 TNF 20200974 2299820 Silencing FOXO1 using siRNA in vitro significantly reduced *induced* apoptosis and [caspase] activity in differentiated chondrocytes . Positive_regulation CASP16 TNF 21269505 2392754 is also *required* for appropriate regulation of [caspase] genes . Positive_regulation CASP16 TNF 21893119 2506516 Conversely , *activation* of [caspase] by exogenous required IL-13 , TWEAK , and Fn14 . Positive_regulation CASP16 TNF 24684347 2935149 Smac-mimetic 1-induced loss of cIAPs correlated with inhibition of mediated NF-?B activation , [caspase] *activation* , and tumor cell killing . Positive_regulation CASP16 TNF 9531309 496840 Furthermore , only murine but not IL-1alphabeta *increased* [caspase] activity and apoptosis . Positive_regulation CASP16 TNF 9885230 584463 *induced* [caspase] activation was accompanied by a decrease in the ability of neutrophils to release superoxide anion . Positive_regulation CASP16 TNF 9885230 584489 Granulocyte-macrophage colony stimulating factor inhibited *induced* [caspase] activation and apoptosis , while reversing the diminution in superoxide release . Positive_regulation CASP16 TNFSF10 11677236 896129 Combining and interferon in vitro , synergistically *induced* apoptosis and [caspase] activation in breast cancer cells . Positive_regulation CASP16 TNFSF10 12815069 1103425 In addition , overexpression of cleavage-site mutant c-IAP1 makes cells more resistant to *induced* [caspase] activation . Positive_regulation CASP16 TNFSF10 14644092 1188265 Furthermore , the enhancement extended to *induced* [caspase-activation] . Positive_regulation CASP16 TNFSF10 14690854 1194693 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , Fas , and receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP16 TNFSF10 15197350 1347069 In this study , we show that TPCK inhibits *induced* [caspase] activity but potentiates wortmannin dependent caspase activity in prostatic carcinoma cell lines . Positive_regulation CASP16 TNFSF10 15558024 1361136 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both promoted by amiloride . Positive_regulation CASP16 TNFSF10 15569667 1368296 Here we demonstrate that human breast cancer cells , but not normal mammary epithelial cells , are dramatically sensitized to induced apoptosis and [caspase] *activation* by peroxisome proliferator activated receptor gamma ( PPARgamma ) agonists of the thiazolidinedione ( TZD ) class . Positive_regulation CASP16 TNFSF10 16103097 1444531 Generation of ROS by CCCP was responsible for *induced* Bax and [caspase] activation because scavenging ROS completely abrogated apical caspase-8 activation and further downstream events leading to cell death . Positive_regulation CASP16 TNFSF10 17031854 1700285 Here we demonstrated that human prostate cancer cells , but not normal prostate cells , are dramatically sensitized to induced apoptosis and [caspase] *activation* by quercetin . Positive_regulation CASP16 TNFSF10 17031854 1700298 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both enhanced by quercetin . Positive_regulation CASP16 TNFSF10 17545549 1751984 We isolated primary tumor cells from 13 astrocytoma and oligoastrocytoma patients of all four WHO grades of malignancy and compared the levels of *induced* apoptosis induction , long-term tumor cell survival , [caspase] , and caspase target cleavage . Positive_regulation CASP16 TNFSF10 17724141 1822430 Rituximab , a CD20 antibody used to treat certain types of NHL , augmented induced [caspase] *activation* in Ramos RA1 and DoHH2 but not BJAB or SC-1 cells , through modulation of intrinsic rather than extrinsic apoptosis signaling . Positive_regulation CASP16 TNFSF10 17804742 1791217 Although the proteolytic processing of procaspase-3 by TRAIL was partially blocked in glioma cells , cotreatment with silibinin efficiently recovered *induced* [caspase] activation in these cells . Positive_regulation CASP16 TNFSF10 18483385 1910836 Aspirin sensitized human breast cancer cells , but not untransformed human mammary epithelial cells , to *induced* [caspase] activation and apoptosis by a cyclooxygenase-2 independent mechanism . Positive_regulation CASP16 TNFSF10 18665234 1943068 Stable knockdown of bid lead to a pronounced resistance to Fas/CD95- and *induced* [caspase] activation and apoptosis , and significantly increased clonogenic survival . Positive_regulation CASP16 TNFSF10 18980244 1995231 While the proteolytic processing of procaspase-3 by TRAIL was partially blocked in various HCC cells treated with TRAIL alone , co-treatment with quercetin efficiently recovered induced [caspase] *activation* . Positive_regulation CASP16 TNFSF10 20400979 2274069 The ability of ovarian cancer ascites to activate Akt and inhibit *induced* cell death and [caspase] activity was decreased by heat inactivation , but was retained in ascites fractions > 5 kDa . Positive_regulation CASP16 TNFSF10 20400979 2274082 These results suggest that ovarian cancer ascites induces FAK and Akt activation in an alphavbeta5 integrin dependent pathway , which confers protection from *induced* cell death and [caspase] activation . Positive_regulation CASP16 TNFSF10 21109947 2366205 *induced* [caspase/p38] activation is responsible for the increased catalytic and invasive activities of Akt . Positive_regulation CASP16 TNFSF10 22991197 2734938 We demonstrate that EGFR targeted in combination with BZB *induced* significantly higher [caspase] activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation CASP16 TNFSF10 23180246 2723798 *induces* autophagic protein cleavage through [caspase] activation in melanoma cell lines under arginine deprivation . Positive_regulation CASP16 TNFSF10 24525736 2914818 Treatment of hepatoma cells with salubrinal , an inhibitor of eIF2a dephosphorylation , enhances *induced* eIF2a phosphorylation , CCAAT/enhancer binding protein homologous protein ( CHOP ) expression and [caspase] activation . Positive_regulation CASP16 TNFSF10 24525736 2914833 Moreover , knockdown of growth arrest and DNA damage-inducible protein 34 ( GADD34 ) , which recruits protein phosphatase 1 to dephosphorylate eIF2a , enhances *induced* eIF2a phosphorylation , CHOP expression , [caspase] activation and apoptosis . Positive_regulation CASP16 TNFSF10 24525736 2914846 Knockdown of CHOP abrogates the stimulation of *induced* [caspase] activation and apoptosis by salubrinal . Positive_regulation CASP2 CAPN8 11449356 836199 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Positive_regulation CASP2 CAPN8 12358768 994333 Calpain inhibitor III ( MDL-28170 ) reduced caspase activation , suggesting that [caspase] activation was *mediated* by . Positive_regulation CASP2 CAPN8 12917442 1151035 Interestingly , the overexpression of parkin induced the activation of an intracellular cysteine protease , calpain , but not [caspase] , and the cytoprotective effect of parkin on alpha-synuclein cytotoxicity was significantly *inhibited* by the presence of inhibitors . Positive_regulation CASP2 CAPN8 16597613 1604232 However , PD-150606 also attenuated caspase-3 activity and apoptosis at 24 h , suggesting *dependent* [caspase] activation . Positive_regulation CASP2 CCND1 12480939 1078946 Bcl-2 controls [caspase] activation *following* a p53 dependent death signal . Positive_regulation CASP2 EPHB2 15304372 1322268 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Positive_regulation CASP2 EPHB2 16397410 1512942 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP2 EPHB2 17192846 1701817 These effects were paralleled by disruption of Ras -- > and Akt survival pathways , consequent decreased phosphorylation of both mitochondrial bcl-2 and bad proteins , and [caspase] *activation* . Positive_regulation CASP2 EPHB2 19709398 2139132 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Positive_regulation CASP2 EPHB2 20177944 2236697 This [caspase] activation is *mediated* by phosphorylation of Akt and . Positive_regulation CASP2 EPHB2 21364665 2361092 dependent multiple [caspase] *activation* by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP2 EPHB2 22193398 2543472 Overexpression of ZnT-1 markedly reduced LDH release and caspase activation following I/R. Knockdown of endogenous ZnT-1 augmented the I/R induced release of LDH and increased [caspase] *activation* following I/R. levels were significantly increased following I/R in cells overexpressing ZnT-1 , while knockdown of ZnT-1 reduced phospho-ERK levels . Positive_regulation CASP2 EPHB2 22554503 2590592 The activation of increased XIAP expression and *led* to decreased [caspase] activation . Positive_regulation CASP2 FAS 10213689 608072 *induced* [caspase] denitrosylation . Positive_regulation CASP2 FAS 10352269 617205 In strict contrast , TPA is an ineffective inhibitor when cell death is induced by the potassium ionophore valinomycin , the specific mitochondrial benzodiazepine ligand PK11195 , or by primary [caspase] *activation* by cross linking . Positive_regulation CASP2 FAS 10364198 620465 EGF stimulation of epithelial cells also inhibited induced [caspase] *activation* and the proteolysis of signaling proteins downstream of the EGF receptor , Cbl and Akt/protein kinase B ( Akt ) . Positive_regulation CASP2 FAS 10391681 626714 ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , [caspase] activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation CASP2 FAS 10391681 626730 M3/6 prevented Fas stimulation of JNK , but did not affect mediated [caspase] *activation* or cell death , demonstrating that JNK activation is not required for these processes . Positive_regulation CASP2 FAS 10405325 629341 induced [caspase] *activation* and nuclear apoptosis , however , were unaffected by the depletion of ATP . Positive_regulation CASP2 FAS 10464143 640278 Suppression of induced *activation* of the [caspase] by IL-1beta was diminished by coadministration with D-galactosamine and reversed by coinjection with an excess amount of uridine . Positive_regulation CASP2 FAS 10545115 564280 Taken together , these findings argue that hDaxx promotes sensitivity to Fas from a nuclear location , probably by modulating the transcription of genes involved in induced [caspase] *activation* and apoptosis . Positive_regulation CASP2 FAS 10706558 673179 In conclusion , in vivo stimulation *causes* [caspase] activation , mitochondrial permeability transition ( decreasing the membrane potential and increasing basal respiration ) , mitochondrial matrix expansion ( as shown by matrix herniation ) , outer mitochondrial membrane rupture , and cytochrome c release . Positive_regulation CASP2 FAS 10749152 681129 These results indicate that mediated [caspase] *activation* elicits two independent cellular responses ; Positive_regulation CASP2 FAS 10766189 684360 The caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp ( OMe ) fluoromethyl ketone ( zVADfmk ) , at concentrations that completely prevent apoptosis and [caspase] activation *induced* by ligation of the death receptor , had only a partial protective effect on onconase induced cell death . Positive_regulation CASP2 FAS 11260077 796090 ligation increased apoptosis and decreased colony growth equally in RARS and controls , but *caused* significantly more [caspase] activation in RARS ( P < 0.01 ) . Positive_regulation CASP2 FAS 11278283 819064 Staurosporine activates MST either caspase-dependently or independently , whereas ligation *activates* it only [caspase-dependently] . Positive_regulation CASP2 FAS 11295536 801384 NH ( 2 ) Cl pretreatment significantly inhibited apoptosis and [caspase] activation *induced* by etoposide or camptothecin , a DNA topoisomerase I poison , but not by staurosporine or stimulation . Positive_regulation CASP2 FAS 11322649 807142 Gamma-interferon ( IFN-gamma ) augments apoptotic response to mistletoe lectin-II via upregulation of L expression and [caspase] *activation* in human myeloid U937 cells . Positive_regulation CASP2 FAS 11359796 816299 In isolated GC B cells , cFLIP ( L ) decays rapidly even without ligation , and this *results* in activation of [caspase] activity and apoptosis . Positive_regulation CASP2 FAS 11368434 817075 *induced* [caspase] activity is increased in RARS bone marrow cells . Positive_regulation CASP2 FAS 11536010 854844 We conclude that ( i ) synergistic induction of apoptosis by C2-ceramide and CD95L depend on a cross-talk between the two signal transduction pathways and that ( ii ) C2-ceramide , independently of its sensitizing effects on dependent [caspase] *activation* , is also capable of triggering an apoptotic signaling cascade that is unaffected by zVAD-fmk mediated caspase inhibition , but promoted by high levels of CD95 expression . Positive_regulation CASP2 FAS 11551934 882149 PI3-kinase inhibition sensitized to apoptosis by increasing and accelerating mediated [caspase] *activation* . Positive_regulation CASP2 FAS 11673515 872824 Thus , *induced* initiation of [caspase] activity at the plasma membrane may in some cells result in local proteolysis of submembrane proteins , leading to generation of membrane vesicles that are highly enriched in active caspase 8 . Positive_regulation CASP2 FAS 11698497 878160 Interleukin (IL)-5 and interferon (IFN)-gamma , two cytokines known to prolong eosinophil survival , inhibited mediated apoptosis and [caspase] *activation* but poorly affected the decrease in DeltaPsi ( m ) . Positive_regulation CASP2 FAS 11699200 878330 Recent work has demonstrated that the degree of spontaneous caspase activation in FHL lymphocytes is attenuated in vitro whereas mediated [caspase] *activation* and apoptosis induction remains unmitigated , and FHL can thus be distinguished from the related chronic disorder of immune regulation termed autoimmune lymphoproliferative syndrome or ALPS . Positive_regulation CASP2 FAS 11834943 911164 Lamivudine was also found to stimulate in vitro *induced* apoptosis and [caspase] activation in pre activated T lymphocytes from healthy donors . Positive_regulation CASP2 FAS 12165276 972783 Further investigation of *mediated* [caspase] activities revealed that supplementation of glutamine significantly decreased caspase-3 and caspase-8 activities in activated T cells . Positive_regulation CASP2 FAS 12207331 983590 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Positive_regulation CASP2 FAS 12221075 998188 Enforced expression of GPx1 also resulted in inhibition of induced effector [caspase] *activation* , DNA fragmentation , and apoptotic cell death . Positive_regulation CASP2 FAS 12393561 1035689 Moreover , we have previously reported that G-CSF inhibits induced [caspase] *activation* in sideroblastic anemia ( RARS ) . Positive_regulation CASP2 FAS 12393594 1031522 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Positive_regulation CASP2 FAS 12404126 1009724 Structure-function analysis determined that ATP hydrolysis was necessary for P-gp to confer resistance to induced [caspase] *activation* and cell death . Positive_regulation CASP2 FAS 12444127 1017308 These data indicate that TCR ligation can activate nonapoptotic death programs in WT CD8 ( + ) and CD8 ( + ) T blasts that normally are masked by mediated [caspase] *activation* . Positive_regulation CASP2 FAS 12605597 1079481 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block and etoposide *induced* [caspase] activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation CASP2 FAS 12700647 1082030 Myriocin did not modulate the expression of CD95 or CD95L , instead , it interfered with the early steps of mediated [caspase] *activation* . Positive_regulation CASP2 FAS 12760867 1091398 This effect was correlated with an increase in mediated [caspase] *activation* and enhanced cleavage of the caspase substrate poly ( ADP-ribose ) polymerase . Positive_regulation CASP2 FAS 12760867 1091411 Furthermore , the positive effect on mediated [caspase] *activation* by IFN and ribavirin was confirmed by immunocytochemistry for activated caspase-3 and by immunoblot detection of activated caspase-3 , caspase-7 , and caspase-8 . Positive_regulation CASP2 FAS 12760867 1091424 IFN and ribavirin also enhance mediated [caspase] *activation* , which might in part be responsible for the apoptosis promoting effect of these antiviral compounds . Positive_regulation CASP2 FAS 12850790 1109572 Here , newly developed suicide genes , including *inducible* , inducible [caspase] and CD20 are discussed . Positive_regulation CASP2 FAS 12855571 1149819 Importantly , up-regulation of Gadd45 beta by CD40 precedes *induced* [caspase] activation , as well as up-regulation of other NF-kappa B-controlled inhibitors of apoptosis such as Bcl-xL and c-FLIPL . Positive_regulation CASP2 FAS 12938225 1133110 Co-incubation with cycloheximide partially reversed protection from apoptosis and increased *stimulated* initiator and effector [caspase] activation , suggesting new protein synthesis is necessary to induce protection upstream of caspase activation . Positive_regulation CASP2 FAS 14576776 1156538 The spontaneous death of CD4+ and CD8+ T cells was not prevented by a decoy CD95 receptor or by a broad-spectrum caspase inhibitor ( zVAD-fmk ) , suggesting that this form of cell death is independent of interaction and [caspase] *activation* . Positive_regulation CASP2 FAS 14675162 1189360 Both and anti-CD95 antibodies *triggered* [caspase] activation followed by apoptotic death in fully pro-inflammatory astrocytes , whereas resting cells were totally resistant . Positive_regulation CASP2 FAS 14690854 1194674 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , , and TRAIL receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP2 FAS 15197350 1347073 The inhibitory activity of TPCK was found to be death ligand-specific since TPCK inhibits TRAIL mediated caspase activity but does not affect *induced* [caspase] activity . Positive_regulation CASP2 FAS 15322156 1286761 Consistent with its role in cell death induction , deletion of caspase-8 in hepatocytes protected them from *induced* [caspase] activation and death . Positive_regulation CASP2 FAS 15345335 1292176 These events were accompanied by a marked increase of protein expression , and *activation* of [caspase-2] , -3 , -8 . Positive_regulation CASP2 FAS 15648737 1350017 These findings suggest that mild hypothermia suppresses *mediated* apoptosis of liver cells by the partial inhibition of signaling events including mitochondrial damage , cytochrome c release , and subsequent apoptosome formation and effector [caspase] activation . Positive_regulation CASP2 FAS 15863130 1401081 Binding of Fas ligand or agonistic anti-Fas antibody to the death receptor can *activate* a [caspase-cascade] resulting in apoptosis . Positive_regulation CASP2 FAS 16120269 895973 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Positive_regulation CASP2 FAS 16384930 1547173 JAK2 mutated PV erythroblasts showed lower levels of induced [caspase] *activation* and incomplete caspase mediated cleavage of the erythroid transcription factor GATA-1 , which was entirely degraded in normal erythroblasts on CD95 stimulation . Positive_regulation CASP2 FAS 16527894 1574403 Simultaneously , mediated [caspase] *activation* precipitates differentiation . Positive_regulation CASP2 FAS 16646028 1557188 stimulation activated NF-kappaB and AP-1 , and this response *required* [caspase] activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation CASP2 FAS 17245429 1690838 The nucleo-cytoplasmic translocation of FLASH requires *induced* [caspase] activation and is facilitated by the Crm1 dependent nuclear export pathway . Positive_regulation CASP2 FAS 17304508 1718977 These results suggest the possible involvement of multiple signaling pathways from the MAPK to the subsequent mitochondria- and/or mediated [caspase] *activation* are potential requirements for PCA induced AGS apoptosis . Positive_regulation CASP2 FAS 18386902 1907138 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , [caspase] activation , and *induction* . Positive_regulation CASP2 FAS 18593565 1953606 induced [caspase] *activation* leads to degradation of gp130 , thereby suppressing IL-6 induced phosphorylation of STAT3 ( Tyr ( 705 ) ) and of tyrosine phosphatase SHP2 ( Tyr ( 580 ) ) . Positive_regulation CASP2 FAS 18948840 2041284 All *led* to a reduced DISC formation and diminished initiator [caspase] activity upon CD95-stimulation , whereas a marked heterogeneity in sensitivity to CD95 induced killing was found . Positive_regulation CASP2 FAS 19002587 1991267 In epithelial cells , induced hierarchic [caspase] *activation* is also linked with DEDD , a member of the DED family that binds to keratin (K) intermediate filaments ( IFs ) . Positive_regulation CASP2 FAS 19111607 2031763 However , recent studies have shown that can *induce* nonapoptotic [caspase independent cell death (CICD)] when caspase activity is inhibited . Positive_regulation CASP2 FAS 19680267 2157902 CD95 is a death receptor whose stimulation by either the physiologic ligand or the agonistic antibodies *leads* to the formation of a multi-molecular complex termed DISC ( death inducing signaling complex ) and the subsequent induction of a [caspase-driven] apoptotic signal . Positive_regulation CASP2 FAS 20876774 2368748 Simultaneous downregulation of c-FLIP ( L ) and c-FLIP ( S ) as well as individual knockdown of either isoform by RNA interference significantly enhances TRAIL ( tumour necrosis factor related apoptosis inducing ligand ) - and *induced* [caspase] activation and caspase dependent apoptosis . Positive_regulation CASP2 FAS 22543586 2750627 Furthermore , loss of RAGE increased expression of the death receptor CD95 ( Fas , Apo-1 ) , dependent [caspase] *activation* and extrinsic apoptosis , whereas NF-kB-p65 nuclear translocation was diminished . Positive_regulation CASP2 FAS 23029562 2681057 Blocking the ERK pathway using a pharmacological inhibitor increased the susceptibility of 661W cells to induced [caspase] *activation* and apoptosis . Positive_regulation CASP2 FAS 23530784 2762298 Various methods to inhibit apoptosis including the cell surface receptor pathway inhibitors , [caspase] *inhibitors* , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation CASP2 FAS 24928990 2946815 Real-time detection of CTL function reveals distinct patterns of [caspase] activation *mediated* by versus granzyme B . Positive_regulation CASP2 FAS 24928990 2946843 Thus , we have used a novel , real-time assay to demonstrate the distinct pattern of [caspase] activation *induced* by granzyme B versus in human and murine CTLs . Positive_regulation CASP2 FAS 9637489 513681 Here , we investigated whether the apoptosis occurring after TCR/CD9 stimulation is associated with a death pathway involving Fas stimulation and mediated [caspase] *activation* as observed in activation induced cell death ( AICD ) . Positive_regulation CASP2 FAS 9694885 524282 Our results demonstrate that whereas mediated activation of caspase 3 *requires* an upstream [caspase] activity that is zVAD-fmk-sensitive , the initial cleavage of caspase 3 during granule mediated cell death is insensitive to zVAD-fmk , suggesting that caspase 3 is cleaved directly by granzyme B in vivo . Positive_regulation CASP2 FAS 9764613 537372 Anti-Fas MoAb induced apoptosis of RA synovial cells in vitro , and proinflammatory cytokines tumour necrosis factor-alpha (TNF-alpha) and IL-1beta , but not IL-6 or IL-8 , inhibited the *induced* apoptosis accompanying up-regulation of Bcl-2 protein expression and reduced expression of CPP32 and [ICH-1L] . Positive_regulation CASP2 IL1B 14580374 1156928 When compared to control , *increased* [caspase 2] , 3 , 8 and 9 activities , whereas IL-6 treated membranes did not exhibit a significant change . Positive_regulation CASP2 IL1B 16305880 1485811 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , and interleukin-6 , and *activation* of caspase-1 , caspase-3 and [caspase-11] . Positive_regulation CASP2 MAOA 17883400 1830020 Two unrelated inhibitors *reduced* [caspase] activation . Positive_regulation CASP2 MAP2K6 16397410 1512948 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP2 MAP2K6 16672322 1583709 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* [caspase] activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only caspase activity . Positive_regulation CASP2 MAP2K6 21364665 2361098 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP2 MMP28 13679861 1140503 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP2 MMP7 13679861 1140518 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP2 RNASE1 15620724 1357774 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and induced [caspase] *activation* in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP2 RNASE1 15620724 1358008 We find that and RC-RNase/IFN-gamma *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP2 RNASE7 15620724 1357782 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and induced [caspase] *activation* in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP2 RNASE7 15620724 1358016 We find that and RC-RNase/IFN-gamma *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP2 SPHK1 11238741 791080 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Positive_regulation CASP2 TNF 10425195 632756 *induces* [caspase] activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation CASP2 TNF 10586080 571801 Silymarin also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated induced cytotoxicity and [caspase] *activation* . Positive_regulation CASP2 TNF 10593992 572959 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Positive_regulation CASP2 TNF 10764744 698794 Addition of H ( 2 ) O ( 2 ) prevented induced apoptosis and [caspase] *activation* , an effect prevented by simultaneous addition of catalase . Positive_regulation CASP2 TNF 10820260 694388 induced cytotoxicity , [caspase] *activation* , and lipid peroxidation were also abolished by vesnarinone . Positive_regulation CASP2 TNF 10843709 700174 Resveratrol also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated induced cytotoxicity and [caspase] *activation* . Positive_regulation CASP2 TNF 11228746 581005 induced *activation* of [caspase] activity was blocked by all three types of quenchers . Positive_regulation CASP2 TNF 11847111 912593 mediated [caspase] *activation* and block of differentiation are dependent upon the expression of PW1 , but occur independently of NFkappaB activation . Positive_regulation CASP2 TNF 12036088 949066 *promotes* [caspase] activation and apoptosis in human fetal membranes . Positive_regulation CASP2 TNF 12080044 976109 We also showed that stable overexpression of A20 inhibits apoptosis and [caspase] activation *induced* by . Positive_regulation CASP2 TNF 12431778 1015383 Our results demonstrate that TGF-beta1 can decrease TNF-alpha induced apoptosis in murine osteoblasts at least in part by attenuating *induced* [caspase] gene expression . Positive_regulation CASP2 TNF 12663669 1092540 In the presence of cycloheximide , or interleukin-1 *initiates* [caspase] activation , loss of mitochondrial membrane potential ( DeltaPsi ) , DNA degradation , and nuclear condensation and fragmentation characteristic of apoptotic cell death in human vascular endothelial cells ( EC ) . Positive_regulation CASP2 TNF 12763364 1093890 The latter and mediated [caspase] *activation* was attenuated by prostaglandin E ( 2 ) . Positive_regulation CASP2 TNF 12800192 1098914 The antioxidants N-acetylcysteine , reduced glutathione , lipoic acid and ascorbic acid markedly reduced the enhancing effect of the hormone on induced [caspase] *activation* . Positive_regulation CASP2 TNF 12800192 1098927 The effect of calcitriol on DeltaPsi was mimicked by rotenone , which increased both the drop in DeltaPsi and [caspase] activation *induced* by . Positive_regulation CASP2 TNF 15033766 1184108 The antioxidants N-acetylcysteine , glutathione , lipoic acid , and ascorbic acid markedly reduced the effect of the hormone on induced [caspase] *activation* , attesting to the involvement of reactive oxygen species ( ROS ) in the cross-talk between the hormone and the cytokine . Positive_regulation CASP2 TNF 15283855 1277821 In the *presence* of or endotoxin ( LPS ) , blockade of CD18 ( beta2 chain ) with mAb markedly increased [caspase] activation in PMN on fibrinogen . Positive_regulation CASP2 TNF 15452110 1341973 These mutant cells exhibited a defect in *induced* [caspase] activation , Bid cleavage , and release of cytochrome c . Positive_regulation CASP2 TNF 16532377 1555284 Inhibition of the p38 and/or the JNK death pathways reduced [caspase] activation *induced* by oxidative stress , hyperosmotic shock and . Positive_regulation CASP2 TNF 16631528 1552350 We report that DDC strongly inhibits [caspase] activation , loss of DeltaPsim , and cell death *induced* by or etoposide . Positive_regulation CASP2 TNF 17013758 1641447 When apoptosis is induced by doxorubicin or in an intact cell model , cleavage of caspases-8 and -9 , but not [caspase-2] , was markedly *enhanced* by caspase-3 . Positive_regulation CASP2 TNF 17047073 1635888 Importantly , down-regulation of TRAIL by small interfering RNA silencing decreased mediated Adriamycin induced [caspase] *activation* and apoptosis , and thus enhanced breast cancer cell resistance to Adriamycin . Positive_regulation CASP2 TNF 17125837 1686479 ATD5 could also reduce the TNF-alpha mediated cytotoxicity and inhibit mediated [caspase] *activation* on L929 cells in a dose dependent manner . Positive_regulation CASP2 TNF 17599041 1848493 We have recently shown that *induces* [caspase dependent and -independent] JNK activation and ROS accumulation in cellular FLICE-inhibitory protein ( c-Flip ) ( -/- ) murine embryonic fibroblasts ( MEFs ) . Positive_regulation CASP2 TNF 18023359 1832130 Mitochondrial apoptotic inducer bax , and the suppressor bcl-2 were evaluated using western blotting at 48 h. Results indicated that *increased* [caspase] activities and resulted in a significant ( p = 0.001 ) increase in bax/bcl-2 ratio . Positive_regulation CASP2 TNF 18467439 1938877 However , XIAP small interfering RNA restored *induced* [caspase] signaling and apoptosis in Hec-1A cells ; Positive_regulation CASP2 TNF 19345705 2094382 Finally , reconstitution of PPT1 activity in mutant cells was accompanied by resensitization to induced [caspase] *activation* and toxicity . Positive_regulation CASP2 TNF 19440308 2078408 Muscle regeneration is , at least in part , regulated by caspase activation , and AVP abrogated *dependent* [caspase] activation . Positive_regulation CASP2 TNF 20200974 2299811 Silencing FOXO1 using siRNA in vitro significantly reduced *induced* apoptosis and [caspase] activity in differentiated chondrocytes . Positive_regulation CASP2 TNF 21253389 2380240 significantly *increased* only [caspase-2] . Positive_regulation CASP2 TNF 21269505 2392745 is also *required* for appropriate regulation of [caspase] genes . Positive_regulation CASP2 TNF 21893119 2506466 Conversely , *activation* of [caspase] by exogenous required IL-13 , TWEAK , and Fn14 . Positive_regulation CASP2 TNF 24684347 2935140 Smac-mimetic 1-induced loss of cIAPs correlated with inhibition of mediated NF-?B activation , [caspase] *activation* , and tumor cell killing . Positive_regulation CASP2 TNF 9531309 496822 Furthermore , only murine but not IL-1alphabeta *increased* [caspase] activity and apoptosis . Positive_regulation CASP2 TNF 9885230 584454 induced [caspase] *activation* was accompanied by a decrease in the ability of neutrophils to release superoxide anion . Positive_regulation CASP2 TNF 9885230 584480 Granulocyte-macrophage colony stimulating factor inhibited induced [caspase] *activation* and apoptosis , while reversing the diminution in superoxide release . Positive_regulation CASP2 TNFSF10 11677236 896120 Combining and interferon in vitro , synergistically *induced* apoptosis and [caspase] activation in breast cancer cells . Positive_regulation CASP2 TNFSF10 11992615 938775 In the presence of wortmannin *induced* activation of [caspase-2] , -3 , -7 , -8 , and -9 , as well as dissipation of mitochondrial transmembrane potential and release of cyto-chrome c from mitochondria into the cytosol . Positive_regulation CASP2 TNFSF10 12815069 1103416 In addition , overexpression of cleavage-site mutant c-IAP1 makes cells more resistant to *induced* [caspase] activation . Positive_regulation CASP2 TNFSF10 14644092 1188256 Furthermore , the enhancement extended to *induced* [caspase-activation] . Positive_regulation CASP2 TNFSF10 14690854 1194675 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , Fas , and receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP2 TNFSF10 15197350 1347060 In this study , we show that TPCK inhibits *induced* [caspase] activity but potentiates wortmannin dependent caspase activity in prostatic carcinoma cell lines . Positive_regulation CASP2 TNFSF10 15558024 1361127 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both promoted by amiloride . Positive_regulation CASP2 TNFSF10 15569667 1368287 Here we demonstrate that human breast cancer cells , but not normal mammary epithelial cells , are dramatically sensitized to induced apoptosis and [caspase] *activation* by peroxisome proliferator activated receptor gamma ( PPARgamma ) agonists of the thiazolidinedione ( TZD ) class . Positive_regulation CASP2 TNFSF10 16103097 1444522 Generation of ROS by CCCP was responsible for *induced* Bax and [caspase] activation because scavenging ROS completely abrogated apical caspase-8 activation and further downstream events leading to cell death . Positive_regulation CASP2 TNFSF10 17031854 1700276 Here we demonstrated that human prostate cancer cells , but not normal prostate cells , are dramatically sensitized to induced apoptosis and [caspase] *activation* by quercetin . Positive_regulation CASP2 TNFSF10 17031854 1700289 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both enhanced by quercetin . Positive_regulation CASP2 TNFSF10 17545549 1751975 We isolated primary tumor cells from 13 astrocytoma and oligoastrocytoma patients of all four WHO grades of malignancy and compared the levels of *induced* apoptosis induction , long-term tumor cell survival , [caspase] , and caspase target cleavage . Positive_regulation CASP2 TNFSF10 17724141 1822421 Rituximab , a CD20 antibody used to treat certain types of NHL , augmented *induced* [caspase] activation in Ramos RA1 and DoHH2 but not BJAB or SC-1 cells , through modulation of intrinsic rather than extrinsic apoptosis signaling . Positive_regulation CASP2 TNFSF10 17804742 1791208 Although the proteolytic processing of procaspase-3 by TRAIL was partially blocked in glioma cells , cotreatment with silibinin efficiently recovered induced [caspase] *activation* in these cells . Positive_regulation CASP2 TNFSF10 18483385 1910827 Aspirin sensitized human breast cancer cells , but not untransformed human mammary epithelial cells , to *induced* [caspase] activation and apoptosis by a cyclooxygenase-2 independent mechanism . Positive_regulation CASP2 TNFSF10 18665234 1943059 Stable knockdown of bid lead to a pronounced resistance to Fas/CD95- and *induced* [caspase] activation and apoptosis , and significantly increased clonogenic survival . Positive_regulation CASP2 TNFSF10 18980244 1995222 While the proteolytic processing of procaspase-3 by TRAIL was partially blocked in various HCC cells treated with TRAIL alone , co-treatment with quercetin efficiently recovered induced [caspase] *activation* . Positive_regulation CASP2 TNFSF10 20187765 2259234 Furthermore , IFN-beta pretreatment significantly increased the sensitivity against exogenous mediated apoptosis and *activation* of [caspase-2] in G361 . Positive_regulation CASP2 TNFSF10 20400979 2274060 The ability of ovarian cancer ascites to activate Akt and inhibit *induced* cell death and [caspase] activity was decreased by heat inactivation , but was retained in ascites fractions > 5 kDa . Positive_regulation CASP2 TNFSF10 20400979 2274073 These results suggest that ovarian cancer ascites induces FAK and Akt activation in an alphavbeta5 integrin dependent pathway , which confers protection from *induced* cell death and [caspase] activation . Positive_regulation CASP2 TNFSF10 21109947 2366196 *induced* [caspase/p38] activation is responsible for the increased catalytic and invasive activities of Akt . Positive_regulation CASP2 TNFSF10 22991197 2734929 We demonstrate that EGFR targeted in combination with BZB *induced* significantly higher [caspase] activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation CASP2 TNFSF10 23180246 2723789 *induces* autophagic protein cleavage through [caspase] activation in melanoma cell lines under arginine deprivation . Positive_regulation CASP2 TNFSF10 24525736 2914809 Treatment of hepatoma cells with salubrinal , an inhibitor of eIF2a dephosphorylation , enhances induced eIF2a phosphorylation , CCAAT/enhancer binding protein homologous protein ( CHOP ) expression and [caspase] *activation* . Positive_regulation CASP2 TNFSF10 24525736 2914823 Moreover , knockdown of growth arrest and DNA damage-inducible protein 34 ( GADD34 ) , which recruits protein phosphatase 1 to dephosphorylate eIF2a , enhances induced eIF2a phosphorylation , CHOP expression , [caspase] *activation* and apoptosis . Positive_regulation CASP2 TNFSF10 24525736 2914837 Knockdown of CHOP abrogates the stimulation of induced [caspase] *activation* and apoptosis by salubrinal . Positive_regulation CASP3 ARSA 16914308 1626510 Although <5-ASA> *induces* dissipation of mitochondrial transmembrane potential and [caspase-3] activation , zVAD-fmk does not completely prevent the 5-ASA induced cell death . Positive_regulation CASP3 ARSA 18678619 1973300 ASA and NaS at 1 mM did not induce PARP cleavage or [caspase-3] and at 5 mM , but not NaS *increased* apoptosis . Positive_regulation CASP3 ARSA 23896061 2835580 also *increased* [caspase-3] protein levels and dose-dependently increased its activity . Positive_regulation CASP3 CAPN8 11124942 794836 This is the first report to our knowledge suggesting a direct link between the early , excitotoxic , calcium mediated activation of after cerebral hypoxia-ischemia and the subsequent *activation* of [caspase-3] , thus representing a tentative pathway of `` pathological apoptosis . '' Positive_regulation CASP3 CAPN8 11449356 836213 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Positive_regulation CASP3 CAPN8 11449356 836522 Etoposide induced expression of the cleaved , proteolytically active form of [caspase 3] , and DEVD-ase activity , detected prior to nuclear damage , were blocked in the *presence* of inhibitors . Positive_regulation CASP3 CAPN8 12175527 975128 Taken together , the chemopreventive effects of Se-MSC may be related in part to the [caspase-3] activation , the down-regulation of IAP family proteins , and Bax cleavage *mediated* by caspase dependent activation . Positive_regulation CASP3 CAPN8 12358768 994348 Calpain inhibitor III ( MDL-28170 ) reduced caspase activation , suggesting that [caspase] activation was *mediated* by . Positive_regulation CASP3 CAPN8 12453489 1020801 Interestingly , extensive degradation of [caspase-3] occurred already directly after dissection and was at least partly *dependent* . Positive_regulation CASP3 CAPN8 12469198 1032468 Taken together , the apoptotic effects of NPPA may be related , in part to the [caspase-3] activation , the down-regulation of XIAP , and Bax cleavage *mediated* by caspase dependent activation . Positive_regulation CASP3 CAPN8 12917435 1150945 In vivo calpain/caspase cross-talk during 3-nitropropionic acid induced striatal degeneration : implication of a *mediated* cleavage of [active caspase-3] . Positive_regulation CASP3 CAPN8 12917442 1151049 Interestingly , the overexpression of parkin induced the activation of an intracellular cysteine protease , calpain , but not [caspase] , and the cytoprotective effect of parkin on alpha-synuclein cytotoxicity was significantly *inhibited* by the presence of inhibitors . Positive_regulation CASP3 CAPN8 14995081 1182964 We investigated the effect of leupeptin and calpain inhibitor-1 (CAI-1) , two inhibitors and of a [caspase-3] *inhibitor* , Ac-DEVD-CHO , on functional recovery , myocardial infarct size and apoptosis in isolated rat hearts ( Langendorff technique ) subjected to 30 min of global ischemia and 120 min of reperfusion . Positive_regulation CASP3 CAPN8 15139027 1246991 Glutamate induced apoptosis correlated with upregulation of , a proapoptotic shift in the Bax : Bcl-2 ratio , and increased *activation* of [caspase-3] . Positive_regulation CASP3 CAPN8 16597613 1604246 However , PD-150606 also attenuated caspase-3 activity and apoptosis at 24 h , suggesting *dependent* [caspase] activation . Positive_regulation CASP3 CAPN8 17291991 1698632 On the other hand , 6-OHDA induced [caspase-3] activation was inhibited in the *presence* of caspase-8 , caspase-9 , and inhibitors . Positive_regulation CASP3 CAPN8 18214855 1883937 The delays of cytochrome c release , [caspase-3] *activation* and subsequent cell death by inactivating or silencing Bid exclude other earlier or parallel pathways , strongly suggesting that the calpain mediated pathway is the kinetically earliest one , which dominates the cisplatin induced apoptosis . Positive_regulation CASP3 CAPN8 19705411 2151460 Inhibition of not only significantly *reduced* [caspase-9/-3] activities but also completely blocked AIF redistribution . Positive_regulation CASP3 CAPN8 21092655 2350080 in septic mice , myocardial was activated and *induced* [caspase-3] activation , the association between calpain activation and apoptosis was explored in this experiment . Positive_regulation CASP3 CAPN8 22487998 2601631 To test this prediction , we determined whether selective pharmacological inhibition of would *prevent* activation of [caspase-3] and conversely whether selective inhibition of caspase-3 would abate calpain activation . Positive_regulation CASP3 CAPN8 22487998 2601657 Pharmacological inhibition of *prevented* mechanical ventilation induced activation of diaphragmatic [caspase-3] and inhibition of caspase-3 prevented activation of diaphragmatic calpain . Positive_regulation CASP3 CAPN8 22487998 2601714 These findings support our hypothesis that a regulatory calpain/caspase-3 cross-talk exists whereby can *promote* [caspase-3] activation and active caspase-3 can enhance calpain activity in diaphragm muscle during prolonged mechanical ventilation . Positive_regulation CASP3 CAPN8 22751172 2670236 Our aim was to reveal possible protective effects of SpeedyRINGO against *induced* [caspase-3] activation in neurons which is crucial in terms of providing novel insights in preventing the caspase-3 activation cascade in neurodegeneration . Positive_regulation CASP3 CAPN8 23425388 2755370 The role of the Hsp90/Akt pathway in myocardial *induced* [caspase-3] activation and apoptosis during sepsis . Positive_regulation CASP3 CAPN8 23425388 2755384 Recent studies have demonstrated that myocardial *triggers* [caspase-3] activation and myocardial apoptosis in models of sepsis , whereas the inhibition of calpain activity down-regulates myocardial caspase-3 activation and apoptosis . Positive_regulation CASP3 CAPN8 23425388 2755412 Myocardial *induces* myocardial [caspase-3] activation and apoptosis in septic mice via the activation of the Hsp90/Akt pathway . Positive_regulation CASP3 CAPN8 23471945 2781899 Interestingly , inhibition of activity also *prevented* [caspase-3] activation , and , conversely , inhibition of caspase-3 prevented calpain activation . Positive_regulation CASP3 CCND1 12429973 1015149 Tetrandrine induced growth inhibition was associated with induction of Cdk inhibitor p21 , inhibition of and *activation* of [caspase-3] . Positive_regulation CASP3 CCND1 12480939 1078948 Bcl-2 controls [caspase] activation *following* a p53 dependent death signal . Positive_regulation CASP3 CCND1 18321638 1904417 Thio-Cl-IB-MECA induced arrest of cell cycle progression in G0/G1 phase at lower concentrations ( up to 20 microM ) and apoptotic cell death at a higher concentration ( 80 microM ) , which were manifested by down-regulation of , c-myc , and CDK4 , *activation* of [caspase-3] and -9 , and cleavage of poly ( ADP-ribose ) polymerase ( PARP ) . Positive_regulation CASP3 CCND1 18450412 2027987 Indirubin-3-oxime induced growth inhibition was associated with induction of Cdk inhibitor p21 , inhibition of and *activation* of [caspase-3] . Positive_regulation CASP3 CCND1 19880242 2224738 The mechanisms involved inhibition of NF-kappaB activity and consequent inhibition of Bcl-2 , and VEGF , and *activation* of [caspase-3] . Positive_regulation CASP3 CCND1 19998418 2280759 Cell death induced by the extract of P. linteus grown on PBR was shown to be associated with the upregulation of p21 ( CIP1/WAF1 ) , the downregulation of , anti-apoptotic protein , Bcl-2 , the release of cytochrome c , and the *activation* of caspase-9 , [caspase-3] and caspase-8 . Positive_regulation CASP3 CCND1 20512478 2264099 The G(1)/S phase arrest was accompanied by down regulation of , one of the cyclins required for advance from G ( 1 ) to S. Subsequent apoptosis was *induced* by the gradual activation of [caspase-3] and the cleavage of PARP . Positive_regulation CASP3 CCND1 20888245 2363977 The was downregulated and [Caspase 3] was *activated* . Positive_regulation CASP3 DAPK1 23545262 2777744 Moreover , suppression *diminished* curcumin induced [caspase-3] activation . Positive_regulation CASP3 EPHB2 10908618 715566 Pharmacological inhibition of , but not the PI3-kinase pathway , *inhibited* the ability of BDNF to block H-I induced [caspase-3] activation and tissue loss . Positive_regulation CASP3 EPHB2 12082101 976244 In contrast , the suppression of activation with PD98059 , a specific inhibitor of MEK1 , *inhibited* UV- and TPA induced junD mRNA expression , UV-induced increases in [caspase-3] activities , and cell death . Positive_regulation CASP3 EPHB2 15266324 1276007 Functional assays using MEK inhibitors demonstrated that the phosphorylation of MEK and was *required* for the activation of [caspase-3] as the executing caspase . Positive_regulation CASP3 EPHB2 15304372 1322269 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Positive_regulation CASP3 EPHB2 15371330 1323832 Of the three investigated MAPKs , only played an active role in mediating H2S induced apoptosis of HASMCs by *activating* [caspase-3] . Positive_regulation CASP3 EPHB2 15547704 1338344 Functional assays using chemical inhibitors demonstrated that the phosphorylation of was mediated by reactive oxygen species in an Raf-1 independent manner and *required* the activation of [caspase-3] . Positive_regulation CASP3 EPHB2 15964118 1428215 In addition , the malvidin treatment significantly increased the p38 kinase expression and *inhibited* the activity , and the effects of malvidin on [caspase-3] activation were blocked , respectively , by the ERK and p38 inhibitors . Positive_regulation CASP3 EPHB2 16152590 1517330 Bcl-2 phosphorylation and *activation* of and JNK and [caspase 3-dependent] cleavage of PARP were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation CASP3 EPHB2 16397410 1512950 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP3 EPHB2 16445087 1495600 Inhibition of phosphorylation by PD98059 strongly attenuated cadmium induced necrotic cell death , but did not *prevent* [caspase-3] activation and DNA fragmentation . Positive_regulation CASP3 EPHB2 16698853 1604761 In rat primary pulmonary microvascular endothelial cells , simvastatin induced [caspase 3] *activation* and Rac 1 expression while suppressing Rho A and attenuated levels of Akt and phosphorylation . Positive_regulation CASP3 EPHB2 17192846 1701818 These effects were paralleled by disruption of Ras -- > and Akt survival pathways , consequent decreased phosphorylation of both mitochondrial bcl-2 and bad proteins , and [caspase] *activation* . Positive_regulation CASP3 EPHB2 18163394 1889863 Overexpression of constitutively active and PKB *inhibited* staurosporine induced [caspase-3] activation and hepatocyte death . Positive_regulation CASP3 EPHB2 18623086 1941807 In summary , [caspase-3] *induces* activation through a ceramide-dependant , protease activity independent mechanism , which represents a novel role of caspase-3 in tumor metastasis . Positive_regulation CASP3 EPHB2 19709398 2139134 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Positive_regulation CASP3 EPHB2 20077196 2178349 Fifty micromolar HQ markedly increased phosphorylation of and *activation* of [caspase-9/-3] , followed by PARP cleavage . Positive_regulation CASP3 EPHB2 20177944 2236701 This [caspase] activation is *mediated* by phosphorylation of Akt and . Positive_regulation CASP3 EPHB2 20538858 2295651 Reduction of Ca ( 2+ ) influx at early times of infection by various treatments decreased the viral yield and delayed both the early transient [caspase 3] cleavage and the *activation* of FAK , Akt , and signaling . Positive_regulation CASP3 EPHB2 21315038 2393336 Reduction of MC3T3 cell surface cholesterol dramatically inhibited TNFR1 mediated AKT phosphorylation , while did not affect the degradation of I?Ba , *activation* of or p38 , and processing of [caspase-3] induced by TNF-a . Positive_regulation CASP3 EPHB2 21315038 2393340 therefore our results suggest that lipid raft is essential for TNFR1 mediated AKT phosphorylation , but is dispensable for TNFR1 mediated degradation of I?Ba , *activation* of or p38 and processing of [caspase-3] . Positive_regulation CASP3 EPHB2 21364665 2361100 dependent multiple [caspase] *activation* by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP3 EPHB2 21442306 2421885 Using specific inhibitors , we found that MAPK signaling molecules , including ERK , JNK and p38 MAPK , were important for virus release , whereas , only and p38 MAPK were *involved* in STIV induced apoptosis by modulating [caspase-3] activity . Positive_regulation CASP3 EPHB2 21600974 2470296 Although all the MAPKs were activated by carmustine , only the inhibitors of JNK and *prevented* carmustine induced cell death and [caspase-3] activation . Positive_regulation CASP3 EPHB2 22193398 2543475 Overexpression of ZnT-1 markedly reduced LDH release and caspase activation following I/R. Knockdown of endogenous ZnT-1 augmented the I/R induced release of LDH and increased [caspase] *activation* following I/R. levels were significantly increased following I/R in cells overexpressing ZnT-1 , while knockdown of ZnT-1 reduced phospho-ERK levels . Positive_regulation CASP3 EPHB2 22554503 2590593 The activation of increased XIAP expression and *led* to decreased [caspase] activation . Positive_regulation CASP3 EPHB2 22560879 2603177 In addition , down-regulation of *resulted* in activation of [caspase 3] and caspase 9 . Positive_regulation CASP3 EPHB2 23570653 2870231 Subsequent tumor tissue analysis showed that silibinin treatment induced a decrease in Ki-67 positive cells , an increase in transferase mediated dUTP nick end labeling ( TUNEL ) -positive cells , *activation* of [caspase-3] , and inhibition of and p-Akt . Positive_regulation CASP3 FAS 10200474 561097 Wortmannin enhances activation of [CPP32] ( Caspase-3 ) *induced* by TNF or . Positive_regulation CASP3 FAS 10213689 608073 *induced* [caspase] denitrosylation . Positive_regulation CASP3 FAS 10213689 608082 therefore *activates* [caspase-3] not only by inducing the cleavage of the caspase zymogen to its active subunits , but also by stimulating the denitrosylation of its active-site thiol . Positive_regulation CASP3 FAS 10352269 617206 In strict contrast , TPA is an ineffective inhibitor when cell death is induced by the potassium ionophore valinomycin , the specific mitochondrial benzodiazepine ligand PK11195 , or by primary [caspase] *activation* by cross linking . Positive_regulation CASP3 FAS 10352342 617280 Unexpectedly , mutant p53val135 differentially modulated caspase 3 activity in a gain-of-function fashion in that [caspase 3] activity *induced* by was enhanced in LN-229 and LN-308 cells but reduced in LN-18 cells . Positive_regulation CASP3 FAS 10364198 620466 EGF stimulation of epithelial cells also inhibited *induced* [caspase] activation and the proteolysis of signaling proteins downstream of the EGF receptor , Cbl and Akt/protein kinase B ( Akt ) . Positive_regulation CASP3 FAS 10381641 624268 In *response* to activation LA treatment potentiated [caspase 3] activation by over 100 % . Positive_regulation CASP3 FAS 10391681 626715 ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , [caspase] activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation CASP3 FAS 10391681 626731 M3/6 prevented Fas stimulation of JNK , but did not affect mediated [caspase] *activation* or cell death , demonstrating that JNK activation is not required for these processes . Positive_regulation CASP3 FAS 10403377 629015 engagement by an agonistic anti-Fas antibody *resulted* in enhanced [caspase 3] and 8 activity and increased mitochondrial permeability . Positive_regulation CASP3 FAS 10405325 629342 *induced* [caspase] activation and nuclear apoptosis , however , were unaffected by the depletion of ATP . Positive_regulation CASP3 FAS 10464143 640279 Suppression of induced *activation* of the [caspase] by IL-1beta was diminished by coadministration with D-galactosamine and reversed by coinjection with an excess amount of uridine . Positive_regulation CASP3 FAS 10545115 564281 Taken together , these findings argue that hDaxx promotes sensitivity to Fas from a nuclear location , probably by modulating the transcription of genes involved in *induced* [caspase] activation and apoptosis . Positive_regulation CASP3 FAS 10652256 662836 Coincubation of Jurkat cells with a blocking anti-Fas antibody prevented induced but not HNE *induced* activation of [caspase-3] . Positive_regulation CASP3 FAS 10706558 673180 In conclusion , in vivo stimulation *causes* [caspase] activation , mitochondrial permeability transition ( decreasing the membrane potential and increasing basal respiration ) , mitochondrial matrix expansion ( as shown by matrix herniation ) , outer mitochondrial membrane rupture , and cytochrome c release . Positive_regulation CASP3 FAS 10734125 678789 Inhibition of actin polymerization using latrunculin A reduced the ability of constitutively active GTPase mutants to stimulate apoptosis and blocked *induced* activation of [caspase-3] . Positive_regulation CASP3 FAS 10749152 681130 These results indicate that mediated [caspase] *activation* elicits two independent cellular responses ; Positive_regulation CASP3 FAS 10766189 684361 The caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp ( OMe ) fluoromethyl ketone ( zVADfmk ) , at concentrations that completely prevent apoptosis and [caspase] activation *induced* by ligation of the death receptor , had only a partial protective effect on onconase induced cell death . Positive_regulation CASP3 FAS 10845905 700695 IFN-gamma induced Fas expression of the cells without the activation of caspase8 or caspase3 during 16 hours of incubation , while deprivation of EPO induced expression of and the *activation* of both caspase8 and [caspase3] . Positive_regulation CASP3 FAS 10852976 704095 Interestingly , ligation *activated* caspase-8 and [caspase-3] with the cleavage of poly ( ADP-ribose ) polymerase ( PARP ) , corresponding to apoptosis of RA synoviocytes . Positive_regulation CASP3 FAS 11000584 734529 These results indicate that anticancer drugs and gamma-rays prime squamous cell carcinoma cells to be susceptible to apoptosis by LAK cells , that LAK cell induced apoptosis largely depends on the *activation* of [caspase-3] by the signal and granzyme B , and that LAK cells induce ROI in the target cells , which is largely mediated by Fas and granzyme B . Positive_regulation CASP3 FAS 11093032 754917 Osmotic cell shrinkage which was induced by the addition of 100 mM NaCl , did not significantly interfere with induced phosphatidylserine exposure nor the *activation* of [caspase 3] activity as determined by PARP cleavage , DEVD-AMC consumption , or the activation of PAK2-kinase . Positive_regulation CASP3 FAS 11259186 795743 The MC159 expressing virus blocked *induced* activation of [caspase-3] and -8 , degradation of PARP , and cleavage of DNA , whereas the parental vaccinia virus did not . Positive_regulation CASP3 FAS 11260077 796091 ligation increased apoptosis and decreased colony growth equally in RARS and controls , but *caused* significantly more [caspase] activation in RARS ( P < 0.01 ) . Positive_regulation CASP3 FAS 11278283 819065 Staurosporine activates MST either caspase-dependently or independently , whereas ligation *activates* it only [caspase-dependently] . Positive_regulation CASP3 FAS 11295536 801385 NH ( 2 ) Cl pretreatment significantly inhibited apoptosis and [caspase] activation *induced* by etoposide or camptothecin , a DNA topoisomerase I poison , but not by staurosporine or stimulation . Positive_regulation CASP3 FAS 11322649 807144 Gamma-interferon ( IFN-gamma ) augments apoptotic response to mistletoe lectin-II via upregulation of L expression and [caspase] *activation* in human myeloid U937 cells . Positive_regulation CASP3 FAS 11334117 809200 *induced* upregulation of [caspase-1 and -3] expression in the nucleus and cytoplasm in A549 cells . Positive_regulation CASP3 FAS 11343247 813937 The chronic SAA ( - ) diet did not affect hepatic Fas or Bcl-XL , but increased p53 and Bax , and exacerbated mediated mitochondrial membrane depolarization , electron-microscopy-proven outer mitochondrial membrane rupture , cytochrome c translocation to the cytosol , and [caspase 3] *activation* . Positive_regulation CASP3 FAS 11359796 816300 In isolated GC B cells , cFLIP ( L ) decays rapidly even without ligation , and this *results* in activation of [caspase] activity and apoptosis . Positive_regulation CASP3 FAS 11368434 817076 *induced* [caspase] activity is increased in RARS bone marrow cells . Positive_regulation CASP3 FAS 11411462 826520 and ( 6 ) Effect of ethanol on *dependent* [caspase-3] activation and apoptosis in CD4+ T cells , by Shirish S. Barve . Positive_regulation CASP3 FAS 11422788 830986 Exposure to tryptanthrin enhanced *induced* apoptosis and increased [caspase-3] activity before induction of apoptosis . Positive_regulation CASP3 FAS 11438480 832972 The results thus demonstrate that ligand system *mediated* [caspase-3] activation plays a central role in the ethanol induced hepatic apoptosis . Positive_regulation CASP3 FAS 11454065 837125 The NO donor SNAP inhibited *induced* [caspase-3] activation in rheumatoid synovial cells . Positive_regulation CASP3 FAS 11485387 844881 We found that *induced* activation of [caspase-3] was inhibited by whole smoke from both tobacco and marijuana cigarettes . Positive_regulation CASP3 FAS 11485387 844882 However , particulate-phase smoke ( tar ) was a potent inhibitor of *induced* [caspase-3] activity , with marijuana tar being more potent than either tobacco or placebo marijuana tar ( lacking Delta ( 9 ) -THC ) . Positive_regulation CASP3 FAS 11485387 844884 Delta ( 9 ) -THC also inhibited *induced* [caspase-3] activity in A549 cells . Positive_regulation CASP3 FAS 11536010 854837 *induced* [caspase 3-like] activity , cytochrome c release and cleavage of caspases 3 , 8 , 9 and poly ( ADP-ribose ) polymerase ( PARP ) increase substantially after cotreatment with CD95L and C2-ceramide compared with CD95L treatment alone . Positive_regulation CASP3 FAS 11536010 854845 We conclude that ( i ) synergistic induction of apoptosis by C2-ceramide and CD95L depend on a cross-talk between the two signal transduction pathways and that ( ii ) C2-ceramide , independently of its sensitizing effects on dependent [caspase] *activation* , is also capable of triggering an apoptotic signaling cascade that is unaffected by zVAD-fmk mediated caspase inhibition , but promoted by high levels of CD95 expression . Positive_regulation CASP3 FAS 11551934 882150 PI3-kinase inhibition sensitized to apoptosis by increasing and accelerating mediated [caspase] *activation* . Positive_regulation CASP3 FAS 11673515 872825 Thus , *induced* initiation of [caspase] activity at the plasma membrane may in some cells result in local proteolysis of submembrane proteins , leading to generation of membrane vesicles that are highly enriched in active caspase 8 . Positive_regulation CASP3 FAS 11698497 878161 Interleukin (IL)-5 and interferon (IFN)-gamma , two cytokines known to prolong eosinophil survival , inhibited *mediated* apoptosis and [caspase] activation but poorly affected the decrease in DeltaPsi ( m ) . Positive_regulation CASP3 FAS 11699200 878331 Recent work has demonstrated that the degree of spontaneous caspase activation in FHL lymphocytes is attenuated in vitro whereas mediated [caspase] *activation* and apoptosis induction remains unmitigated , and FHL can thus be distinguished from the related chronic disorder of immune regulation termed autoimmune lymphoproliferative syndrome or ALPS . Positive_regulation CASP3 FAS 11834943 911165 Lamivudine was also found to stimulate in vitro induced apoptosis and [caspase] *activation* in pre activated T lymphocytes from healthy donors . Positive_regulation CASP3 FAS 11983446 935624 [Caspase-3] activation *induced* by either tumor necrosis factor-alpha/D-glactosamine or by treatment , was reduced by pretreatment with N-nitrobenzylidene malononitrile . Positive_regulation CASP3 FAS 12011074 962235 In wild-type mice , stimulation *resulted* in normal activation of [caspase-3] , with the generation of the active p19-p12 complex . Positive_regulation CASP3 FAS 12165276 972784 Further investigation of *mediated* [caspase] activities revealed that supplementation of glutamine significantly decreased caspase-3 and caspase-8 activities in activated T cells . Positive_regulation CASP3 FAS 12207331 983591 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Positive_regulation CASP3 FAS 12221075 998190 Enforced expression of GPx1 also resulted in inhibition of induced effector [caspase] *activation* , DNA fragmentation , and apoptotic cell death . Positive_regulation CASP3 FAS 12354208 993514 Results demonstrated up-regulation of and *activation* of [caspase-3] in T cells in response to A. actinomycetemcomitans CFCS . Positive_regulation CASP3 FAS 12393561 1035690 Moreover , we have previously reported that G-CSF inhibits *induced* [caspase] activation in sideroblastic anemia ( RARS ) . Positive_regulation CASP3 FAS 12393594 1031523 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Positive_regulation CASP3 FAS 12404126 1009706 Previous studies by our laboratory have shown that the drug transporter protein P-glycoprotein , P-gp , can specifically inhibit *induced* [caspase-3] activation and apoptosis . Positive_regulation CASP3 FAS 12404126 1009725 Structure-function analysis determined that ATP hydrolysis was necessary for P-gp to confer resistance to *induced* [caspase] activation and cell death . Positive_regulation CASP3 FAS 12444127 1017309 These data indicate that TCR ligation can activate nonapoptotic death programs in WT CD8 ( + ) and CD8 ( + ) T blasts that normally are masked by mediated [caspase] *activation* . Positive_regulation CASP3 FAS 12522131 1047837 We found that *induced* activation of [caspase-3] does not promote macrophage lysis and caspase-3 activation is not required for OxLDL induced macrophage lysis . Positive_regulation CASP3 FAS 12605597 1079482 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block and etoposide *induced* [caspase] activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation CASP3 FAS 12700647 1082031 Myriocin did not modulate the expression of CD95 or CD95L , instead , it interfered with the early steps of mediated [caspase] *activation* . Positive_regulation CASP3 FAS 12704141 1082316 Our results show that up-regulation is *followed* by early activation of [caspase-8 and -3] and cleavage of the caspase-3 substrate poly ( ADP-ribose ) polymerase . Positive_regulation CASP3 FAS 12760867 1091399 This effect was correlated with an increase in mediated [caspase] *activation* and enhanced cleavage of the caspase substrate poly ( ADP-ribose ) polymerase . Positive_regulation CASP3 FAS 12760867 1091412 Furthermore , the positive effect on mediated [caspase] *activation* by IFN and ribavirin was confirmed by immunocytochemistry for activated caspase-3 and by immunoblot detection of activated caspase-3 , caspase-7 , and caspase-8 . Positive_regulation CASP3 FAS 12760867 1091425 IFN and ribavirin also enhance mediated [caspase] *activation* , which might in part be responsible for the apoptosis promoting effect of these antiviral compounds . Positive_regulation CASP3 FAS 12763364 1093886 By contrast IL-6 inhibited *induced* increase in [caspase-3] activity by 45 % and significantly reduced chromatin condensation . Positive_regulation CASP3 FAS 12850790 1109573 Here , newly developed suicide genes , including *inducible* , inducible [caspase] and CD20 are discussed . Positive_regulation CASP3 FAS 12855571 1149820 Importantly , up-regulation of Gadd45 beta by CD40 precedes induced [caspase] *activation* , as well as up-regulation of other NF-kappa B-controlled inhibitors of apoptosis such as Bcl-xL and c-FLIPL . Positive_regulation CASP3 FAS 12861043 1111698 Neither caspase-8 nor [caspase-3] was activated by agonistic anti-Fas antibody alone , but both caspases were *activated* by stimulation in the presence of ActD or CHX , indicating the importance of caspase-8 inhibitors that are sensitive to metabolic inhibitors . Positive_regulation CASP3 FAS 12938225 1133111 Co-incubation with cycloheximide partially reversed protection from apoptosis and increased *stimulated* initiator and effector [caspase] activation , suggesting new protein synthesis is necessary to induce protection upstream of caspase activation . Positive_regulation CASP3 FAS 14576776 1156539 The spontaneous death of CD4+ and CD8+ T cells was not prevented by a decoy CD95 receptor or by a broad-spectrum caspase inhibitor ( zVAD-fmk ) , suggesting that this form of cell death is independent of interaction and [caspase] *activation* . Positive_regulation CASP3 FAS 14617692 1209985 Depletion of primary afferent nerve fibers by neonatal capsaicin treatment prevented *mediated* activation of [caspase-3] , measured as enzymatic activity in liver homogenates or by demonstration of hepatocellular immunoreactivity for active caspase-3 in liver slices , and liver damage . Positive_regulation CASP3 FAS 14675162 1189361 Both and anti-CD95 antibodies *triggered* [caspase] activation followed by apoptotic death in fully pro-inflammatory astrocytes , whereas resting cells were totally resistant . Positive_regulation CASP3 FAS 14690854 1194676 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , , and TRAIL receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP3 FAS 14738570 1242698 ligation significantly *increased* the activities of both Caspase 1 and [Caspase 3] at 20 hours of stimulation ( 1.7- and 2.0-fold versus control , both p < 0.05 ) ; Positive_regulation CASP3 FAS 14871831 1208283 *induced* activation of [caspase-3] was detected in the nuclear fraction and in whole cell lysate . Positive_regulation CASP3 FAS 15015772 1220819 U-105 MG , U-251 MG , and SF-767 were resistant to Fas induced apoptosis as shown by the lack of *induced* cell death , morphological changes , annexin-V reactivity , Parp cleavage , caspase-3 cleavage , and [caspase-3] activation . Positive_regulation CASP3 FAS 15144569 1247586 After HuIFN-beta exposure , COH and CC-M2 cells showed increased levels of and FasL proteins , alteration of mitochondrial membrane potential , and *activation* of caspase-9 , caspase-8 , and [caspase-3] in a time dependent manner . Positive_regulation CASP3 FAS 15192017 1295273 To investigate this possibility , we studied the influence of bovine lactoferrin on Fas mediated apoptosis with regard to expression of , *activation* of caspase-8 and [caspase-3] , and DNA fragmentation in the colon mucosa of AOM treated rats . Positive_regulation CASP3 FAS 15197350 1347074 The inhibitory activity of TPCK was found to be death ligand-specific since TPCK inhibits TRAIL mediated caspase activity but does not affect *induced* [caspase] activity . Positive_regulation CASP3 FAS 15322156 1286762 Consistent with its role in cell death induction , deletion of caspase-8 in hepatocytes protected them from induced [caspase] *activation* and death . Positive_regulation CASP3 FAS 15370668 1297379 Also , increased expression of the pro-apoptotic Bcl-2 members Bax , Bad and activation of [caspase 3] and caspase 9 , but not the *activation* of caspase 8 or were detected in the NS1 transfected cells . Positive_regulation CASP3 FAS 15454145 1301149 LPS significantly ( p < 0.05 ) reduced spontaneous ( 66.1 +/- 2.3 % to 24.8 +/- 4.8 % ) and *induced* ( 90.8 +/- 0.9 % to 64.3 +/- 4.2 % ) apoptosis and [caspase-3] activation . Positive_regulation CASP3 FAS 15454145 1301150 Inhibition of the proteasome completely abolished the antiapoptotic effect of LPS on spontaneous ( 52.6 +/- 2.4 % ) and *induced* ( 88.7 +/- 2.6 % ) apoptosis and degradation of [caspase-3] . Positive_regulation CASP3 FAS 15585371 1356171 By measuring the cellular Hg2+ content following various exposure conditions , we have determined that a cellular Hg2+ burden of approximately 50 ng/10 ( 6 ) cells is sufficient to impair mediated [caspase-3] *activation* . Positive_regulation CASP3 FAS 15648737 1350018 These findings suggest that mild hypothermia suppresses mediated apoptosis of liver cells by the partial inhibition of signaling events including mitochondrial damage , cytochrome c release , and subsequent apoptosome formation and effector [caspase] *activation* . Positive_regulation CASP3 FAS 15726400 1409634 Gemcitabine treatment , as well as stimulation of , *resulted* in cleavage of effector [caspase 3] as well as its substrate PARP and caspase 9 , followed by DNA fragmentation . Positive_regulation CASP3 FAS 15863130 1401082 Binding of Fas ligand or agonistic anti-Fas antibody to the death receptor can *activate* a [caspase-cascade] resulting in apoptosis . Positive_regulation CASP3 FAS 15863130 1401091 Analysis of the Fas apoptotic pathway showed that treatment *induced* caspase-8 activation and concomitantly Bid cleavage , caspase-9 and [caspase-3] activation , PARP cleavage and apoptosis in HeLa and CaSki . Positive_regulation CASP3 FAS 16120269 895974 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Positive_regulation CASP3 FAS 16330535 1512013 ligation *increased* [caspase-3] and -8 activities during T cell activation , irrespective of cell fate . Positive_regulation CASP3 FAS 16384930 1547174 JAK2 mutated PV erythroblasts showed lower levels of *induced* [caspase] activation and incomplete caspase mediated cleavage of the erythroid transcription factor GATA-1 , which was entirely degraded in normal erythroblasts on CD95 stimulation . Positive_regulation CASP3 FAS 16386699 1512725 We conclude that *induced* [caspase-3] activation in HT-22 cells was readily detected at the single-cell level using the DsRed-EYFP based FRET construct , making this a useful technology to monitor caspase-3 activity in living cells . Positive_regulation CASP3 FAS 16527894 1574404 Simultaneously , mediated [caspase] *activation* precipitates differentiation . Positive_regulation CASP3 FAS 16646028 1557192 stimulation activated NF-kappaB and AP-1 , and this response *required* [caspase] activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation CASP3 FAS 16786109 1577399 It was found that CSE treatment resulted in the upregulation of receptor and *activation* of [caspase-3] . Positive_regulation CASP3 FAS 16808908 1586045 Increased expression results in a higher susceptibility to Fas mediated apoptosis , which contributes to the increased levels of intracellular *activated* [caspase-3] and accelerates apoptosis of T lymphocytes . Positive_regulation CASP3 FAS 17114647 1693329 Neutralizing ligand interaction *led* to decreased [Caspase-3] activity and lowered Ly-GDI fragmentation . Positive_regulation CASP3 FAS 17208988 1732438 Ten days post-MI , apoptosis among granulation tissue cells was significantly suppressed in the olmesartan treated hearts , where expression of , Bax , procaspase-3 , and Daxx and *activation* of [caspase-3] , c-Jun NH ( 2 ) -terminal kinase , and c-Jun were all significantly attenuated . Positive_regulation CASP3 FAS 17245429 1690839 The nucleo-cytoplasmic translocation of FLASH requires induced [caspase] *activation* and is facilitated by the Crm1 dependent nuclear export pathway . Positive_regulation CASP3 FAS 17304508 1718978 These results suggest the possible involvement of multiple signaling pathways from the MAPK to the subsequent mitochondria- and/or mediated [caspase] *activation* are potential requirements for PCA induced AGS apoptosis . Positive_regulation CASP3 FAS 17692826 1788556 *induced* activation of [caspase-3] and PARP cleavage in WT cells but not in TNF receptor deleted cells . Positive_regulation CASP3 FAS 18157585 1918900 TIMP-3 treatment induced the expression of and Fasl proteins , and the *activation* of caspase-8 and [caspase-3] . Positive_regulation CASP3 FAS 18209090 1857839 S1P also enhanced expression and Fas mediated [caspase-3] *induction* in salivary gland epithelial cells . Positive_regulation CASP3 FAS 18386902 1907139 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , [caspase] activation , and *induction* . Positive_regulation CASP3 FAS 18593565 1953607 *induced* [caspase] activation leads to degradation of gp130 , thereby suppressing IL-6 induced phosphorylation of STAT3 ( Tyr ( 705 ) ) and of tyrosine phosphatase SHP2 ( Tyr ( 580 ) ) . Positive_regulation CASP3 FAS 18948840 2041285 All *led* to a reduced DISC formation and diminished initiator [caspase] activity upon CD95-stimulation , whereas a marked heterogeneity in sensitivity to CD95 induced killing was found . Positive_regulation CASP3 FAS 19002587 1991268 In epithelial cells , *induced* hierarchic [caspase] activation is also linked with DEDD , a member of the DED family that binds to keratin (K) intermediate filaments ( IFs ) . Positive_regulation CASP3 FAS 19111607 2031764 However , recent studies have shown that can *induce* nonapoptotic [caspase independent cell death (CICD)] when caspase activity is inhibited . Positive_regulation CASP3 FAS 19193734 2054145 The expression of and active caspase-3 was localized in the same cell types as apoptosis occurred , and expression levels of Fas , FasL , and [active caspase-3] were significantly *increased* compared with controls . Positive_regulation CASP3 FAS 19429345 2077273 Matrine induces apoptosis in gastric carcinoma cells via alteration of and *activation* of [caspase-3] . Positive_regulation CASP3 FAS 19680267 2157903 CD95 is a death receptor whose stimulation by either the physiologic ligand or the agonistic antibodies *leads* to the formation of a multi-molecular complex termed DISC ( death inducing signaling complex ) and the subsequent induction of a [caspase-driven] apoptotic signal . Positive_regulation CASP3 FAS 20471514 2258017 The combined treatment resulted in a stronger activation of caspase 8 and 9 , moderate *activation* of [caspase 3] , and increased expression of and tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) -DR5 receptors . Positive_regulation CASP3 FAS 20876774 2368749 Simultaneous downregulation of c-FLIP ( L ) and c-FLIP ( S ) as well as individual knockdown of either isoform by RNA interference significantly enhances TRAIL ( tumour necrosis factor related apoptosis inducing ligand ) - and *induced* [caspase] activation and caspase dependent apoptosis . Positive_regulation CASP3 FAS 20926796 2343342 We describe a mechanism whereby NKG2D signaling in human T and NK cells initiates Fas mediated [caspase-3/-7] *activation* and resultant CD3? degradation . Positive_regulation CASP3 FAS 21711425 2447148 DFO suppressed the *induced* production of reactive oxygen species ( ROS ) and the activation of [caspase-3] , both of which were also suppressed by antioxidant , N-acetyl-L-cystein . Positive_regulation CASP3 FAS 21717192 2538825 The induction of apoptosis appears to occur through the upregulation of and Bax , downregulation of Bcl-2 , and *activation* of [caspase-3] , -8 , and -9 , which then trigger major apoptotic cascades . Positive_regulation CASP3 FAS 21914378 2479402 NaF at the doses of 10 , 50 and 100 mg/L for 60 d and 90 d caused overexpression , *promoted* activity of [caspase-3] and caspase-8 , increased apoptosis rate in mandibular incisor cells . Positive_regulation CASP3 FAS 22543586 2750628 Furthermore , loss of RAGE increased expression of the death receptor CD95 ( Fas , Apo-1 ) , *dependent* [caspase] activation and extrinsic apoptosis , whereas NF-kB-p65 nuclear translocation was diminished . Positive_regulation CASP3 FAS 23029562 2681058 Blocking the ERK pathway using a pharmacological inhibitor increased the susceptibility of 661W cells to *induced* [caspase] activation and apoptosis . Positive_regulation CASP3 FAS 23132899 2696543 We found that STC induces apoptosis in these cells in a dose dependent manner and leads to the activation of and caspase-8 , cleavage of Bid , mitochondrial damage , and *activation* of [caspase-3] . Positive_regulation CASP3 FAS 23530784 2762299 Various methods to inhibit apoptosis including the cell surface receptor pathway inhibitors , [caspase] *inhibitors* , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation CASP3 FAS 24622841 2930166 p53 mediated expression and subsequent downstream caspase-8 activation as well as p53 independent caspase-9 activation all *contribute* to the activation of the downstream effector [caspase-3/-7] , leading to tumor cell death . Positive_regulation CASP3 FAS 24928990 2946817 Real-time detection of CTL function reveals distinct patterns of [caspase] activation *mediated* by versus granzyme B . Positive_regulation CASP3 FAS 24928990 2946835 Remarkably , the *dependent* , [caspase 3/7] biosensor signal induced by perforin-deficient human CTLs was also detectable after a 90-min delay when measured by redirected killing . Positive_regulation CASP3 FAS 24928990 2946845 Thus , we have used a novel , real-time assay to demonstrate the distinct pattern of [caspase] activation *induced* by granzyme B versus in human and murine CTLs . Positive_regulation CASP3 FAS 8617770 359186 Here we report that an N-terminal truncation of one of these candidate signal transducers , FADD/MORT1 , abrogates induced apoptosis , ceramide generation , and *activation* of the cell death protease [Yama/CPP32] . Positive_regulation CASP3 FAS 8663439 368592 *induced* activation of the cell death related protease [CPP32] Is inhibited by Bcl-2 and by ICE family protease inhibitors . Positive_regulation CASP3 FAS 8663439 368595 Heterologous expression of Bcl-2 in Jurkat cells prevents *induced* cell death as well as proteolytic processing and activation of [CPP32] . Positive_regulation CASP3 FAS 8912630 395408 [CPP32] , but not ICE , was activated in *response* to stimulation . Positive_regulation CASP3 FAS 9184075 436559 The results showed that Fas mediated apoptosis was accompanied by caspase 3 activation , and both mediated apoptosis and [caspase 3] *activation* were prevented by a serine proteinase inhibitor . Positive_regulation CASP3 FAS 9311830 455082 Moreover , the mechanism of action of BHRF1 resembled that of Bcl-2 and Bcl-xL as it inhibited TNF- and induced *activation* of two enzymes participating in the apoptosis pathway , cytosolic phospholipase A2 and [caspase-3/CPP32] , but did not interfere with the activation of NF-kappaB-like transcription factors . Positive_regulation CASP3 FAS 9398401 468979 Ligation of CD40 potentiates mediated *activation* of the [cysteine protease CPP32] , cleavage of its death substrate PARP , and apoptosis in Ramos-Burkitt lymphoma B cells . Positive_regulation CASP3 FAS 9618532 510310 Inhibition of P-gp function also enhanced drug or *mediated* activation of [caspase-3] in drug-resistant CEM cells . Positive_regulation CASP3 FAS 9637489 513682 Here , we investigated whether the apoptosis occurring after TCR/CD9 stimulation is associated with a death pathway involving Fas stimulation and mediated [caspase] *activation* as observed in activation induced cell death ( AICD ) . Positive_regulation CASP3 FAS 9655522 516273 Interestingly , changes in mitochondrial function or induction of [caspase-3-like] activity *induced* by or doxorubicin were not inhibited by A20 . Positive_regulation CASP3 FAS 9670853 519608 IFN-alpha enhances *induced* activation of [caspase-3] , a critical mediator of CD95L induced cell death . Positive_regulation CASP3 FAS 9694885 524284 Our results demonstrate that whereas *mediated* activation of [caspase 3] requires an upstream caspase activity that is zVAD-fmk-sensitive , the initial cleavage of caspase 3 during granule mediated cell death is insensitive to zVAD-fmk , suggesting that caspase 3 is cleaved directly by granzyme B in vivo . Positive_regulation CASP3 FAS 9764613 537373 Anti-Fas MoAb induced apoptosis of RA synovial cells in vitro , and proinflammatory cytokines tumour necrosis factor-alpha (TNF-alpha) and IL-1beta , but not IL-6 or IL-8 , inhibited the *induced* apoptosis accompanying up-regulation of Bcl-2 protein expression and reduced expression of [CPP32] and ICH-1L . Positive_regulation CASP3 FAS 9786425 540886 Thiol deprivation increased [CPP32] activation *induced* by engagement , but not by ceramides . Positive_regulation CASP3 FAS 9933116 589324 Further , as a result of Bcl-2 overexpression , we found that hGH greatly depressed *induced* activation of the cysteine protease [caspase-3] ( CPP32 ) , which in turn affected the cleavage of poly ( ADP-ribose ) polymerase . Positive_regulation CASP3 FOXO1 19902175 2197526 Diabetic wounds had increased TNF-alpha , fibroblast apoptosis , [caspase-3/7] activity and *activation* of the pro-apoptotic transcription factor , and decreased proliferating cell nuclear antigen positive fibroblasts ( p < 0.05 ) . Positive_regulation CASP3 GLP1R 24269940 2893112 Finally , GW exerted anti-apoptotic effects via interfering with *dependent* Akt/Bcl-2 and [Bcl-xl/caspase-3] signaling pathways . Positive_regulation CASP3 GRIK2 19449206 2136067 As result , the inhibition of JNK activation caused by diminishes the phosphorylation of the transcription factor c-Jun , down-regulates FasL expression and *attenuates* bax translocation , release of cytochrome c and the activation of [caspase-3] . Positive_regulation CASP3 IL1B 12081657 958436 while in vitro analysis indicated that the *induced* increase in [caspase-3] activity was abrogated by the p38 inhibitor , SB203580 . Positive_regulation CASP3 IL1B 12091394 984417 The data are consistent with the idea that activation of p38 plays a significant role in inducing the changes described since *induced* activation of cytochrome c translocation and [caspase-3] activation in cortical tissue in vitro were reversed by the p38 inhibitor SB203580 . Positive_regulation CASP3 IL1B 12540519 1050543 8. This study demonstrates that injection of a selective caspase-1 inhibitor after myocardial ischaemia markedly reduced the detrimental effect conferred by hypercholesterolaemia on myocardial ischaemia-reperfusion injury by attenuating both necrotic as well as apoptotic cell death pathways through inhibition of production and *activation* of caspase-1 and [caspase-3] . Positive_regulation CASP3 IL1B 14563479 1154845 Novel roles for palmitoylation of Ras in induced nitric oxide release and [caspase 3] *activation* in insulin secreting beta cells . Positive_regulation CASP3 IL1B 14563479 1154846 CER-treatment also prevented *induced* activation of [caspase 3] in these cells . Positive_regulation CASP3 IL1B 15201138 1288919 N ( G ) -monomethyl-l-arginine , a known inhibitor of inducible nitric oxide synthetase (iNOS) , markedly inhibited *induced* iNOS gene expression , NO release , [caspase-3] and caspase-6 activation , lamin B degradation , and loss of metabolic cell viability , indicating that the observed IL-1beta induced effects on nuclear lamin B involve the intermediacy of NO . Positive_regulation CASP3 IL1B 16153910 1455393 The kidney was analyzed for expression of tumor necrosis factor alpha , , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 mitogen activated protein kinase , [caspase 3] , and caspase 8 ( Western blot ) . Positive_regulation CASP3 IL1B 16305880 1485827 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , and interleukin-6 , and *activation* of caspase-1 , caspase-3 and [caspase-11] . Positive_regulation CASP3 IL1B 17404069 1721528 Resveratrol inhibits *induced* stimulation of [caspase-3] and cleavage of PARP in human articular chondrocytes in vitro . Positive_regulation CASP3 IL1B 17621647 1775035 In parallel with its ability to decrease microglial activation in vivo , we report that treatment of cultured glia with dexamethasone and vitamin D3 blocked the lipopolysaccharide increased MHCII mRNA and IL-1beta concentration , while the *induced* increases in activation of JNK and [caspase 3] in cultured neurons were also reversed by treatment with dexamethasone and vitamin D3 . Positive_regulation CASP3 IL1B 18372240 1888327 [Caspase-3] activity was *increased* by and the pro-inflammatory cytokine combination , and to a lesser extent by TNFalpha . Positive_regulation CASP3 IL1B 18456542 1938768 In beta-TC3 cells , NT activates both MAP and PI-3 kinases pathways and strongly reduces the staurosporine or the *induced* [caspase-3] activity by a mechanism involving Akt activation . Positive_regulation CASP3 IL1B 18606398 1984325 Furthermore , we observed that resveratrol as well as ALLN inhibited *induced* apoptosis , [caspase-3] activation and PARP cleavage in human articular chondrocytes . Positive_regulation CASP3 IL1B 19037001 1998744 *caused* depletion of intracellular ATP , loss of mitochondrial transmembrane potential , [caspase-3/7] activation , and LDH release . Positive_regulation CASP3 IL1B 19836480 2203148 Curcumin blocks *induced* proteoglycan degradation , AP-1/NF-kappaB signalling , chondrocyte apoptosis and activation of [caspase-3] . Positive_regulation CASP3 IL1B 20678474 2311832 Gene expression of [caspase-3] was *increased* by ( P < 0.05 vs. control ; 100ng/ml ; 3h ) , and pro-caspase-3 but not active caspase was detected in lysates of pig heart cells by Western blotting . Positive_regulation CASP3 LBP 24595452 2920502 at the dose of 40 mg/kg significantly *suppressed* overexpression of Bax , CytC , [Caspase-3] , -9 and cleaved PARP-1 , and inhibited the reduction of Bcl-2 expression . Positive_regulation CASP3 LGALS7B 11706006 903899 Further analyses of actinomycin D-induced apoptosis demonstrated that expression *causes* enhanced [caspase-3] activity and poly ( ADP-ribose ) polymerase cleavage , and the potentiation of apoptosis by galectin-7 was completely abrogated by a caspase inhibitor , benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone . Positive_regulation CASP3 MAOA 17883400 1830021 Two unrelated inhibitors *reduced* [caspase] activation . Positive_regulation CASP3 MAP2K6 11518502 851600 Activation of [caspase-3] and induction of apoptosis are *blocked* both by a inhibitor and by emetine treatment which inhibits MEK kinase ( Mos ) synthesis . Positive_regulation CASP3 MAP2K6 12815279 1103437 Further , we show that may *regulate* [caspase-3] activation via the regulation of XIAP expression in these cells . Positive_regulation CASP3 MAP2K6 15266324 1276013 Functional assays using MEK inhibitors demonstrated that the phosphorylation of and ERK was *required* for the activation of [caspase-3] as the executing caspase . Positive_regulation CASP3 MAP2K6 16013042 1447412 Cisplatin induced an increase in Bax expression , mitochondrial membrane depolarization , mitochondrial cytochrome c release and [caspase-3] activation , and these changes were *prevented* by the inhibitor . Positive_regulation CASP3 MAP2K6 16397410 1512956 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP3 MAP2K6 16672322 1583718 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* [caspase] activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only caspase activity . Positive_regulation CASP3 MAP2K6 20545600 2308384 The inhibitor slightly *reduced* cell growth and [caspase-3] activity in MG132 treated As4.1 cells and mildly increased MMP ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation CASP3 MAP2K6 21364665 2361106 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP3 MMP28 12750841 1107403 As ( 2 ) O ( 3 ) induced apoptosis in parent MOLT-4 cells and MOLT-4/DNR cells expressing functional P-gp via depletion of intracellular GSH , and subsequent disruption of and *activation* of [caspase-3] . Positive_regulation CASP3 MMP28 13679861 1140525 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP3 MMP28 15190933 1256857 Decrease of mitochondria , release of cytochrome c from mitochondria , and *activation* of [caspase-3] were enhanced after the combined treatment . Positive_regulation CASP3 MMP28 16325779 1503478 The cell death was accompanied by disruption of mitochondrial , genomic DNA fragmentation , and [caspase-3] *activation* . Positive_regulation CASP3 MMP28 16877372 1625519 Using cell culture assay model , we revealed in our results that ginkgolide B treatment of ESCs ( ESC-B5 ) induced apoptosis via reactive oxygen species ( ROS ) generation , c-Jun N-terminal kinase (JNK) activation , loss of mitochondrial and the *activation* of [caspase-3] . Positive_regulation CASP3 MMP28 17331071 1733794 Experiments in embryonic stem cells ( ESC-B5 ) showed that CTN induces apoptosis via ROS ( reactive oxygen species ) generation , increased Bax/Bcl-2 ratio , loss of ( mitochondrial membrane potential ) , induction of cytochrome c release , and *activation* of [caspase 3] . Positive_regulation CASP3 MMP28 17573851 1903009 Apoptosis signalling was monitored by assessment of EPS , disruption of and *activation* of [caspase-3] by flow cytometry . Positive_regulation CASP3 MMP28 17709105 1842524 Incubation of human neutrophils with live trichomonads caused marked receptor shedding of CD16 , decrease of mitochondrial and [caspase-3] *activation* in human neutrophils . Positive_regulation CASP3 MMP28 18313257 1978934 The sulforaphane induced apoptosis in U937 cells correlated with the generation of intracellular ROS , collapse of , *activation* of [caspase-3] , and down-regulation of anti-apoptotic Bcl-2 expression . Positive_regulation CASP3 MMP28 18313257 1978975 The quenching of ROS generation with antioxidant N-acetyl-L-cysteine conferred significant protection against sulforaphane elicited ROS generation , disruption of the , [caspase-3] *activation* and apoptosis . Positive_regulation CASP3 MMP28 18804340 2028386 The results of this study demonstrate that platycodon D mediates ROS production , and that this mediation is followed by a decrease in mitochondrial membrane potential ( , DJm ) , *activation* of [caspase-3] , and cleavage of poly ( ADP-ribose ) polymerase ( PARP ) . Positive_regulation CASP3 MMP28 19259823 2072614 Significant enhancement of Fas externalization , loss of mitochondrial , and *activation* of [caspase-3] and caspase-8 were observed after the combined treatment . Positive_regulation CASP3 MMP28 20111678 2178683 In the present study , we examined the effects of resveratrol on apoptotic biochemical events in Hep G2 cells induced by CTN. Resveratrol inhibited CTN induced ROS generation , activation of JNK , loss of mitochondrial , as well as *activation* of caspase-9 , [caspase-3] and PAK2 . Positive_regulation CASP3 MMP28 20545600 2308304 MG132 inhibited the growth of As4.1 cells and induced cell death , accompanied by the loss of mitochondrial membrane potential ( ) and *activation* of [caspase-3] and -8 . Positive_regulation CASP3 MMP28 21334318 2415183 Cafestol induced apoptosis is associated with the reduction of mitochondrial , *activation* of [caspase 3] , cytochrome c release , and down-regulation of anti-apoptotic proteins ( Bcl-2 , Bcl-xL , Mcl-1 and cFLIP ) . Positive_regulation CASP3 MMP28 21595920 2445653 Curcumin induced apoptosis was associated with reduced expression of both Bcl-2 mRNA and protein , subsequent loss of , and *activation* of [caspase-3] followed by PARP degradation . Positive_regulation CASP3 MMP28 21656837 2532039 Furthermore , increase of ROS , loss of , *activation* of [caspase-3] , and down-regulation of Bcl-2 expression was observed . Positive_regulation CASP3 MMP28 21723035 2461010 TMEM14A prevented 4-HPR induced loss of mitochondrial , the release of cytochrome c , and the *activation* of [caspase-3] , but not the generation of reactive oxygen species , suggesting that TMEM14A regulates mitochondrial membrane potential in a ROS independent manner . Positive_regulation CASP3 MMP28 21793156 2803045 Further investigation of these processes revealed that MG directly promotes reactive oxygen species ( ROS ) generation , loss of mitochondrial , and *activation* of [caspase-3] , whereas resveratrol effectively blocks MG-induced ROS production and the accompanying apoptotic biochemical changes . Positive_regulation CASP3 MMP28 21865727 2473437 The apoptosis of AML cells after 4-AP treatment was further confirmed by the disruption of mitochondrial and *activation* of [caspase 3] and 9 . Positive_regulation CASP3 MMP28 22053095 2557293 Less [caspase 3] localized in ovaries of rTIMP1 compared with the other two groups , and was thus *dependent* on action . Positive_regulation CASP3 MMP28 23000516 2720126 Addition of the cathepsin B inhibitor CA-074me reduces Bax activation , loss of , [caspase-3] *activation* and cell death upon treatment with GDC-0941/B10 . Positive_regulation CASP3 MMP28 24098753 2852314 Furthermore , our results revealed that induction of apoptosis through a mitochondrial pathway led to up-regulation of pro-apoptotic protein expression ( Bax ) , down-regulation of anti-apoptotic protein expression ( Bcl-2 ) , mitochondrial release of cytochrome c (Cyto c) , reduction of mitochondrial and *activation* of [caspase-3 (Casp-3)] . Positive_regulation CASP3 MMP28 24335836 2895054 Consistently , bornyl caffeate increased Bax and decreased Bcl-xl , resulting in the disruption of and subsequent *activation* of [caspase-3] . Positive_regulation CASP3 MMP7 12750841 1107418 As ( 2 ) O ( 3 ) induced apoptosis in parent MOLT-4 cells and MOLT-4/DNR cells expressing functional P-gp via depletion of intracellular GSH , and subsequent disruption of and *activation* of [caspase-3] . Positive_regulation CASP3 MMP7 13679861 1140540 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP3 MMP7 15190933 1256873 Decrease of mitochondria , release of cytochrome c from mitochondria , and *activation* of [caspase-3] were enhanced after the combined treatment . Positive_regulation CASP3 MMP7 16325779 1503493 The cell death was accompanied by disruption of mitochondrial , genomic DNA fragmentation , and [caspase-3] *activation* . Positive_regulation CASP3 MMP7 16877372 1625534 Using cell culture assay model , we revealed in our results that ginkgolide B treatment of ESCs ( ESC-B5 ) induced apoptosis via reactive oxygen species ( ROS ) generation , c-Jun N-terminal kinase (JNK) activation , loss of mitochondrial and the *activation* of [caspase-3] . Positive_regulation CASP3 MMP7 17331071 1733810 Experiments in embryonic stem cells ( ESC-B5 ) showed that CTN induces apoptosis via ROS ( reactive oxygen species ) generation , increased Bax/Bcl-2 ratio , loss of ( mitochondrial membrane potential ) , induction of cytochrome c release , and *activation* of [caspase 3] . Positive_regulation CASP3 MMP7 17573851 1903024 Apoptosis signalling was monitored by assessment of EPS , disruption of and *activation* of [caspase-3] by flow cytometry . Positive_regulation CASP3 MMP7 17709105 1842539 Incubation of human neutrophils with live trichomonads caused marked receptor shedding of CD16 , decrease of mitochondrial and [caspase-3] *activation* in human neutrophils . Positive_regulation CASP3 MMP7 18313257 1978949 The sulforaphane induced apoptosis in U937 cells correlated with the generation of intracellular ROS , collapse of , *activation* of [caspase-3] , and down-regulation of anti-apoptotic Bcl-2 expression . Positive_regulation CASP3 MMP7 18313257 1978990 The quenching of ROS generation with antioxidant N-acetyl-L-cysteine conferred significant protection against sulforaphane elicited ROS generation , disruption of the , [caspase-3] *activation* and apoptosis . Positive_regulation CASP3 MMP7 18804340 2028401 The results of this study demonstrate that platycodon D mediates ROS production , and that this mediation is followed by a decrease in mitochondrial membrane potential ( , DJm ) , *activation* of [caspase-3] , and cleavage of poly ( ADP-ribose ) polymerase ( PARP ) . Positive_regulation CASP3 MMP7 19259823 2072629 Significant enhancement of Fas externalization , loss of mitochondrial , and *activation* of [caspase-3] and caspase-8 were observed after the combined treatment . Positive_regulation CASP3 MMP7 20111678 2178698 In the present study , we examined the effects of resveratrol on apoptotic biochemical events in Hep G2 cells induced by CTN. Resveratrol inhibited CTN induced ROS generation , activation of JNK , loss of mitochondrial , as well as *activation* of caspase-9 , [caspase-3] and PAK2 . Positive_regulation CASP3 MMP7 20545600 2308319 MG132 inhibited the growth of As4.1 cells and induced cell death , accompanied by the loss of mitochondrial membrane potential ( ) and *activation* of [caspase-3] and -8 . Positive_regulation CASP3 MMP7 21334318 2415198 Cafestol induced apoptosis is associated with the reduction of mitochondrial , *activation* of [caspase 3] , cytochrome c release , and down-regulation of anti-apoptotic proteins ( Bcl-2 , Bcl-xL , Mcl-1 and cFLIP ) . Positive_regulation CASP3 MMP7 21595920 2445668 Curcumin induced apoptosis was associated with reduced expression of both Bcl-2 mRNA and protein , subsequent loss of , and *activation* of [caspase-3] followed by PARP degradation . Positive_regulation CASP3 MMP7 21656837 2532054 Furthermore , increase of ROS , loss of , *activation* of [caspase-3] , and down-regulation of Bcl-2 expression was observed . Positive_regulation CASP3 MMP7 21723035 2461027 TMEM14A prevented 4-HPR induced loss of mitochondrial , the release of cytochrome c , and the *activation* of [caspase-3] , but not the generation of reactive oxygen species , suggesting that TMEM14A regulates mitochondrial membrane potential in a ROS independent manner . Positive_regulation CASP3 MMP7 21793156 2803060 Further investigation of these processes revealed that MG directly promotes reactive oxygen species ( ROS ) generation , loss of mitochondrial , and *activation* of [caspase-3] , whereas resveratrol effectively blocks MG-induced ROS production and the accompanying apoptotic biochemical changes . Positive_regulation CASP3 MMP7 21865727 2473452 The apoptosis of AML cells after 4-AP treatment was further confirmed by the disruption of mitochondrial and *activation* of [caspase 3] and 9 . Positive_regulation CASP3 MMP7 22053095 2557308 Less [caspase 3] localized in ovaries of rTIMP1 compared with the other two groups , and was thus *dependent* on action . Positive_regulation CASP3 MMP7 23000516 2720141 Addition of the cathepsin B inhibitor CA-074me reduces Bax activation , loss of , [caspase-3] *activation* and cell death upon treatment with GDC-0941/B10 . Positive_regulation CASP3 MMP7 24098753 2852329 Furthermore , our results revealed that induction of apoptosis through a mitochondrial pathway led to up-regulation of pro-apoptotic protein expression ( Bax ) , down-regulation of anti-apoptotic protein expression ( Bcl-2 ) , mitochondrial release of cytochrome c (Cyto c) , reduction of mitochondrial and *activation* of [caspase-3 (Casp-3)] . Positive_regulation CASP3 MMP7 24335836 2895069 Consistently , bornyl caffeate increased Bax and decreased Bcl-xl , resulting in the disruption of and subsequent *activation* of [caspase-3] . Positive_regulation CASP3 MYH16 16395406 1506124 Further , this diet prevents a number of pathologic indicators in males , including fibrosis , induction of , inactivation of glycogen synthase kinase 3beta ( GSK3beta ) , and [caspase-3] *activation* . Positive_regulation CASP3 MYH3 16395406 1506132 Further , this diet prevents a number of pathologic indicators in males , including fibrosis , induction of , inactivation of glycogen synthase kinase 3beta ( GSK3beta ) , and [caspase-3] *activation* . Positive_regulation CASP3 NES 19409199 2082456 NPCs under OGD conditions exhibited reduction of Akt phosphorylation , decrease of the Bcl-2/Bax ratio , *activation* of [caspase-3] , cleavage of PARP , and downregulation of beta-catenin and . Positive_regulation CASP3 OSR1 23952904 2850288 Furthermore , *induced* [caspase-3] activity in the hypoxic cells . Positive_regulation CASP3 PGC 22266669 2580053 Under the condition of hypoxia concomitant with serum deprivation , the overexpression of in MSCs *resulted* in a higher expression level of hypoxia-inducible factor-1a (Hif-1a) , a greater ratio of B-cell lymphoma leukemia-2 (Bcl-2)/Bcl-2 associated X protein (Bax) , and a lower level of [caspase 3] compared with the controls , followed by an increased survival rate and an elevated expression level of several proangiogenic factors . Positive_regulation CASP3 RNASE1 15620724 1357787 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and induced [caspase] *activation* in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP3 RNASE1 15620724 1358021 We find that and RC-RNase/IFN-gamma *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP3 RNASE7 15620724 1357795 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and induced [caspase] *activation* in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP3 RNASE7 15620724 1358029 We find that and RC-RNase/IFN-gamma *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP3 S100B 19910580 2189350 In rat neonatal cardiac myocyte cultures , at concentrations > or = 50 nmol/L *induced* myocyte apoptosis , as evidenced by increased terminal DNA fragmentation , TUNEL , cytochrome c release from mitochondria to cytoplasm , phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2 and p53 , increased expression and activity of proapoptotic [caspase-3] , and decreased expression of antiapoptotic Bcl-2 . Positive_regulation CASP3 SNCAIP 19857556 2187720 Overexpression of significantly *reduced* Rotenone induced cell death , [caspase-3] activation and PARP cleavage . Positive_regulation CASP3 SPHK1 11238741 791082 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Positive_regulation CASP3 TNF 10075082 594859 *induced* cytotoxicity and activation of [caspase-3] were also abolished by beta-lapachone . Positive_regulation CASP3 TNF 10200474 561096 Wortmannin enhances activation of [CPP32] ( Caspase-3 ) *induced* by or anti-Fas . Positive_regulation CASP3 TNF 10355595 618054 DbcAMP also inhibited the *induced* activation of [caspase-3] , but it had no effect on the activation of caspase-8 in human neutrophils . Positive_regulation CASP3 TNF 10358077 618748 In addition , IFN-gamma/TNF-alpha and *stimulate* activation of caspase-8 and [caspase-3] , which IL-13 pretreatment was able to partially inhibit and delay . Positive_regulation CASP3 TNF 10381360 624098 Western blot analyses confirmed that [caspase-3] was not activated in *response* to . Positive_regulation CASP3 TNF 10425195 632757 *induces* [caspase] activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation CASP3 TNF 10439045 635256 mediated cytotoxicity and *activation* of [caspase-3] were both abrogated in gamma-GCS overexpressing cells . Positive_regulation CASP3 TNF 10586080 571802 Silymarin also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated *induced* cytotoxicity and [caspase] activation . Positive_regulation CASP3 TNF 10593992 572960 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Positive_regulation CASP3 TNF 10617950 657248 Our results indicated that linoleic acid and independently , but more markedly in concert , *up-regulated* [caspase-3] activity and induced annexin V binding and DNA fragmentation . Positive_regulation CASP3 TNF 10720949 677033 Overexpression of I kappa B delta N augmented *induced* [caspase-3] and caspase-8 activity , but did not affect Bcl-2 or Bax protein expression . Positive_regulation CASP3 TNF 10723061 579416 Interferon-gamma augmented the *activation* of [CPP32] by in HOG cells and O2A ( + ) oligodendrocyte precursor cells but had no effect on mature oligodendrocytes . Positive_regulation CASP3 TNF 10764146 683989 Both GM-CSF and TNF induced [caspase 3-like] activity in this cell line though the time course was distinct between two cytokines , and combined stimulation of cells with GM-CSF plus *induced* additive or synergistic activation of caspase 3-like activity . Positive_regulation CASP3 TNF 10764744 698789 The activities of [caspase-3] and -8 were *increased* by , with the highest activities found in mC5 cells . Positive_regulation CASP3 TNF 10764744 698795 Addition of H ( 2 ) O ( 2 ) prevented *induced* apoptosis and [caspase] activation , an effect prevented by simultaneous addition of catalase . Positive_regulation CASP3 TNF 10820260 694389 *induced* cytotoxicity , [caspase] activation , and lipid peroxidation were also abolished by vesnarinone . Positive_regulation CASP3 TNF 10843709 700175 Resveratrol also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated *induced* cytotoxicity and [caspase] activation . Positive_regulation CASP3 TNF 10854232 704237 Cytochrome c-dependent *activation* of [caspase-3] by requires induction of the mitochondrial permeability transition . Positive_regulation CASP3 TNF 10973919 729086 Expression of Rac1N17 blocked *induced* activation of nuclear factor-kappa B (NF-kappaB) , increased activity of [caspase-3] , and markedly augmented endothelial cell susceptibility to TNF induced apoptosis . Positive_regulation CASP3 TNF 11067939 747595 Furthermore , the inhibition of the Mek1/Mek2 -- > ERK1/ERK2 or PI3-K/Akt pathways reversed CPPD crystal associated suppression of *induced* [caspase 3] activation and neutrophil apoptosis . Positive_regulation CASP3 TNF 11068016 747625 [Caspase-3] *activation* by was significantly enhanced by pretreatment with both cycloheximide and pyrrolidine dithiocarbamate . Positive_regulation CASP3 TNF 11095643 755311 In contrast , stress activated protein kinase and nuclear factor kappaB activation , which represent primary signals of receptor interaction , downregulation of the antiapoptotic protein Bcl-x ( L ) , and [caspase-3-like] protease *activation* , were unaffected . Positive_regulation CASP3 TNF 11228746 581006 induced *activation* of [caspase] activity was blocked by all three types of quenchers . Positive_regulation CASP3 TNF 11230338 789272 On the other hand , treatment with rHGF attenuated the increase in LDH release and [caspase-3] activity *induced* by stimulation . Positive_regulation CASP3 TNF 11288141 800364 *stimulates* [caspase-3] activation and apoptotic cell death in primary septo-hippocampal cultures . Positive_regulation CASP3 TNF 11288141 800392 Results of this study suggest may *induce* [caspase-3] activation but not calpain activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation CASP3 TNF 11597994 870350 In aged cells , oxLDL and *induced* apoptosis and [caspase-3-like] activity were significantly enhanced more than 3-fold compared with young cells ( passage 3 ) . Positive_regulation CASP3 TNF 11755130 890228 [Caspase-3] *activation* by was observed in these tissue neutrophils , although its activity was significantly weaker than that in circulating blood neutrophils . Positive_regulation CASP3 TNF 11827262 909402 Additionally , we found that the inhibition of NFkappaB by Adv-SR-IkappaBalpha enhanced mediated [caspase-8 and -3] *activation* . Positive_regulation CASP3 TNF 11835405 911417 Additionally , *induced* [caspase-3] and caspase-8 activation and TNF induced PARP cleavage were unaffected by the presence or absence of STAT1 . Positive_regulation CASP3 TNF 11847111 912594 mediated [caspase] *activation* and block of differentiation are dependent upon the expression of PW1 , but occur independently of NFkappaB activation . Positive_regulation CASP3 TNF 11983446 935623 [Caspase-3] activation *induced* by either or by anti-Fas treatment , was reduced by pretreatment with N-nitrobenzylidene malononitrile . Positive_regulation CASP3 TNF 12036088 949067 *promotes* [caspase] activation and apoptosis in human fetal membranes . Positive_regulation CASP3 TNF 12077131 976074 did not activate caspase-8 but *activated* [caspase-3] , -10 , and -12 . Positive_regulation CASP3 TNF 12080044 976112 We also showed that stable overexpression of A20 inhibits apoptosis and [caspase] activation *induced* by . Positive_regulation CASP3 TNF 12117953 964683 We demonstrate here that ADP constitutively released in the medium by A. castellanii , interacting with specific P2y(2) purinoceptors expressed on the monocytic cell membrane , caused a biphasic rise in [ Ca ( 2+ ) ] ( i ) , morphological changes characteristics of cells undergoing apoptosis , [caspase-3] *activation* , and secretion of . Positive_regulation CASP3 TNF 12374208 996560 *activated* caspase 8 and [caspase 3] in PC12 cells , leading to cell death by apoptosis ( DNA fragmentation ) . Positive_regulation CASP3 TNF 12431778 1015384 Our results demonstrate that TGF-beta1 can decrease TNF-alpha induced apoptosis in murine osteoblasts at least in part by attenuating *induced* [caspase] gene expression . Positive_regulation CASP3 TNF 12494458 1033460 FSS activated PI3-kinase signaling , induced phosphorylation of Akt , and inhibited *induced* activation of [caspase-3] . Positive_regulation CASP3 TNF 12568116 1029445 + IFNgamma did not *induce* [caspase 3] activation in primary mouse islets . Positive_regulation CASP3 TNF 12663669 1092568 In the presence of cycloheximide , or interleukin-1 *initiates* [caspase] activation , loss of mitochondrial membrane potential ( DeltaPsi ) , DNA degradation , and nuclear condensation and fragmentation characteristic of apoptotic cell death in human vascular endothelial cells ( EC ) . Positive_regulation CASP3 TNF 12763364 1093891 The latter and mediated [caspase] *activation* was attenuated by prostaglandin E ( 2 ) . Positive_regulation CASP3 TNF 12800192 1098915 The antioxidants N-acetylcysteine , reduced glutathione , lipoic acid and ascorbic acid markedly reduced the enhancing effect of the hormone on *induced* [caspase] activation . Positive_regulation CASP3 TNF 12800192 1098928 The effect of calcitriol on DeltaPsi was mimicked by rotenone , which increased both the drop in DeltaPsi and [caspase] activation *induced* by . Positive_regulation CASP3 TNF 12829021 1105052 The cell lines overexpressing MnSOD ( 1F2 or 2C6 ) displayed decreased radiation induced , induced , or IL-3 withdrawal *induced* mitochondrial membrane permeability , [caspase-3] and PARP activation , and apoptosis . Positive_regulation CASP3 TNF 14568339 1155281 *induces* apoptosis in cultured cerebral endothelial cells through the cleavage of [caspase-3] . Positive_regulation CASP3 TNF 14646488 480066 This dominant mutation in II-5 cells blocks *induced* disruption of mitochondrial membrane potential and [caspase-3] activation . Positive_regulation CASP3 TNF 14738570 1242701 in contrast , purified *increased* the activity of [Caspase 3] but not Caspase 1 ( 2.1-fold , p < 0.05 ) . Positive_regulation CASP3 TNF 14766793 1227395 In primary rat hepatocytes expressing an IkappaB superrepressor , the JNK inhibitor SP600125 strongly decreased *induced* cell death , [caspase 3] activation , and DNA laddering . Positive_regulation CASP3 TNF 15033766 1184109 The antioxidants N-acetylcysteine , glutathione , lipoic acid , and ascorbic acid markedly reduced the effect of the hormone on *induced* [caspase] activation , attesting to the involvement of reactive oxygen species ( ROS ) in the cross-talk between the hormone and the cytokine . Positive_regulation CASP3 TNF 15094967 1238350 Pretreatment of cells with the PPAR-gamma ligand pioglitazone blocked mediated apoptosis , [caspase-3] *activation* , expression of Bcl-2 , and lipid peroxidation ( P < .01 vs TNF-alpha alone ) . Positive_regulation CASP3 TNF 15269006 1302348 Both BzATP and *activated* [caspase-3] , suggesting that BzATP activates predominantly the mitochondrial apoptotic pathway . Positive_regulation CASP3 TNF 15283855 1277822 In the *presence* of or endotoxin ( LPS ) , blockade of CD18 ( beta2 chain ) with mAb markedly increased [caspase] activation in PMN on fibrinogen . Positive_regulation CASP3 TNF 15389560 1304790 Fluorometric studies demonstrated that in vivo predominantly *increased* [caspase-8 and -3] activity and by use of specific inhibitors , the activation of caspase-3 was shown to be initiated by caspase-8 with only a minor contribution from caspase-9 . Positive_regulation CASP3 TNF 15452110 1341974 These mutant cells exhibited a defect in induced [caspase] *activation* , Bid cleavage , and release of cytochrome c . Positive_regulation CASP3 TNF 15499968 1326830 The aim of current study was to investigate the effect of PKCalpha activation by FB1 on NF-kappaB activation and subsequently on gene expression and [caspase 3] *induction* in LLC-PK1 cells . Positive_regulation CASP3 TNF 15585371 1356170 whereas *induced* [caspase-3] activation is not . Positive_regulation CASP3 TNF 15663790 1369556 Inhibition of in vivo *prevents* hyperoxia mediated activation of [caspase 3] in type II cells . Positive_regulation CASP3 TNF 15733908 1378005 A similar DNA fragmentation and [caspase 3] activation was *induced* by , but without Bcl-xS/Bcl-xL increase , cytochrome c release or caspase 9 activation . Positive_regulation CASP3 TNF 15941855 1434085 The effect of DFMO on induced *upregulation* of [caspase-3] activity was reversed by the addition of 100 microM putrescine , confirming that polyamines were really involved in the apoptotic process . Positive_regulation CASP3 TNF 15965903 1497710 Pre-treatment of chondrocytes with alpha-difluoromethylornithine ( DFMO ) , an ornithine decarboxylase (ODC) inhibitor , markedly reduced putrescine and spermidine content as well as the [caspase-3] activation and DNA fragmentation *induced* by and CHX . Positive_regulation CASP3 TNF 15972258 1497946 Inhibition of MEK potentiated *induced* [caspase-3] activity and cell death , and both those events were suppressed by treatment with fostriecin or calyculin A. Immunoprecipitation experiments revealed an association between p38 MAPK , PP2A and MEK , and the results of a phosphatase assay suggested that PP2A is a downstream target of p38 MAPK . Positive_regulation CASP3 TNF 15978880 1446445 Ghrelin also inhibited TNFalpha induced apoptosis and suppressed [caspase-3] activation that occurs in *response* to as well as during in vitro differentiation process . Positive_regulation CASP3 TNF 16263807 1539296 *initiated* caspase-8 activity and cleavage of [pro-caspase-3] at the convergence point of the two pathways . Positive_regulation CASP3 TNF 16487927 1528509 Overexpression of Monad in HEK293 cells potentiated apoptosis and [caspase-3] activation *induced* by and cycloheximide . Positive_regulation CASP3 TNF 16488414 1528525 In addition , 4-HC was shown to elevate *induced* [caspase-3] activation . Positive_regulation CASP3 TNF 16507891 1529594 At 21 hours , inhibition significantly *reduced* fibroblast apoptosis and [caspase-3] activity in both diabetic and normoglycemic mice ( P < 0.05 ) . Positive_regulation CASP3 TNF 16532377 1555285 Inhibition of the p38 and/or the JNK death pathways reduced [caspase] activation *induced* by oxidative stress , hyperosmotic shock and . Positive_regulation CASP3 TNF 16631528 1552351 We report that DDC strongly inhibits [caspase] activation , loss of DeltaPsim , and cell death *induced* by or etoposide . Positive_regulation CASP3 TNF 16717090 1584794 treatment *induced* eIF2alpha phosphorylation and activation of [caspase 3] primarily through the dsRNA activated eIF2alpha kinase PKR . Positive_regulation CASP3 TNF 16801388 1579400 Cdc6-UM expression attenuates the *induced* activation of ATM and [caspase-3] activities . Positive_regulation CASP3 TNF 17038555 1674591 *increased* [caspase 3/7] activity ( an indicator of apoptosis ) and decreased cell viability dose and time dependently . Positive_regulation CASP3 TNF 17047073 1635889 Importantly , down-regulation of TRAIL by small interfering RNA silencing decreased mediated Adriamycin induced [caspase] *activation* and apoptosis , and thus enhanced breast cancer cell resistance to Adriamycin . Positive_regulation CASP3 TNF 17125837 1686480 ATD5 could also reduce the TNF-alpha mediated cytotoxicity and inhibit mediated [caspase] *activation* on L929 cells in a dose dependent manner . Positive_regulation CASP3 TNF 17274948 1697424 Stimulation of the cells with IL6RIL6 plus *resulted* in both the activation of [caspase-3] and the reduction of bcl-2 expression . Positive_regulation CASP3 TNF 17309437 1699466 Since HLDF-6 peptide decreases the number of cells entering apoptosis caused by C ( 2 ) -ceramide , a mediator of TNF induced apoptosis , and also reduces *mediated* activation of [caspase-3] , we have proposed the hypothesis that HLDF-6 increases resistance of HL-60 cells to the TNF-alpha cytotoxic effect due to inhibition of some stages of mitochondria dependent apoptotic signaling . Positive_regulation CASP3 TNF 17357832 1783484 [Caspase 3] and 7 activity was significantly *increased* by with GM stimulation . Positive_regulation CASP3 TNF 17438131 1742789 Interference by alpha-4 DND or alpha-4 siRNA increased [caspase 3/7] activation in *response* to . Positive_regulation CASP3 TNF 17463158 1731677 Furthermore , *induced* activations of [caspase 3] and caspase 8 in the liver were significantly inhibited by zinc pretreatment . Positive_regulation CASP3 TNF 17525369 1767233 We found that PKCzeta activity was required for *mediated* JNK and [caspase-3] activation in ECs . Positive_regulation CASP3 TNF 17599041 1848494 We have recently shown that *induces* [caspase dependent and -independent] JNK activation and ROS accumulation in cellular FLICE-inhibitory protein ( c-Flip ) ( -/- ) murine embryonic fibroblasts ( MEFs ) . Positive_regulation CASP3 TNF 17635674 1798715 Pro-apoptotic caspase-3 was induced by cocaine starting at 30 min. *induced* [caspase-3] activity earlier than cocaine ( 15 and 20 min ) . Positive_regulation CASP3 TNF 18023359 1832131 Mitochondrial apoptotic inducer bax , and the suppressor bcl-2 were evaluated using western blotting at 48 h. Results indicated that *increased* [caspase] activities and resulted in a significant ( p = 0.001 ) increase in bax/bcl-2 ratio . Positive_regulation CASP3 TNF 18054255 1918874 As quantified by flow cytometry , *induced* a higher level of [caspase-3] and -8 activation than that seen with IL-1beta+Ro. Pre-incubation for 2h with caspase inhibitors for caspase-3 , -7 , -8 and pan-caspase significantly decreased the hypodiploid DNA peak induced by treatment with TNF-alpha+Ro at 24 h. Indomethacin increased the cell death induced by IL-1beta+Ro ; Positive_regulation CASP3 TNF 18182160 1856529 Western blot analysis revealed that *induced* activation of [caspase 3] and Mst1 in a time- and dose dependent manner . Positive_regulation CASP3 TNF 18182160 1856535 Diphenyleneiodonium , an inhibitor of NADPH oxidase , and N-acetylcysteine , a potent antioxidant , also inhibited *induced* activation of Mst1 and [caspase 3] , as well as apoptosis . Positive_regulation CASP3 TNF 18288467 1896599 Overexpression of EAPF/Phafin-2 also enhances *induced* activity of [caspase 3] ( but not caspase 8 or 9 ) , and promotes TNF-alpha triggered mitochondrial membrane permeabilization (MMP) in L929 cells , including dissipation of mitochondrial membrane potential and release of AIF . Positive_regulation CASP3 TNF 18331441 1904678 TNF-alpha ( 10 ( -8 ) mol/L ) treatment showed small but significant increases of caspase 3/7 activity in RPTEC , and AT1 and AT2 receptor blockers ( 10 ( -8 ) mol/L ) comparably decreased *induced* [caspase 3/7] activity . Positive_regulation CASP3 TNF 18372240 1888326 [Caspase-3] activity was *increased* by IL-1beta and the pro-inflammatory cytokine combination , and to a lesser extent by . Positive_regulation CASP3 TNF 18393301 1899347 The synergistic *role* of IFNgamma and in activating [caspase-3] in cholangiocytes and the decreased apoptosis following pharmacologic inhibition of caspases support a prominent role for apoptosis in the pathogenesis of experimental biliary atresia . Positive_regulation CASP3 TNF 18467439 1938878 However , XIAP small interfering RNA restored *induced* [caspase] signaling and apoptosis in Hec-1A cells ; Positive_regulation CASP3 TNF 18486908 1910950 All these results demonstrate that ursolic acid induce apoptosis via inhibition of NF-kappaB induced bcl-2 mediated anti-apoptotic pathway and subsequent activation of p53 mediated and *induced* [caspase-3] mediated pro-apoptotic pathways . Positive_regulation CASP3 TNF 18687707 2011736 STAT5b knockdown in T84 CEC increased *dependent* NF-kappaB and [caspase-3] activation . Positive_regulation CASP3 TNF 18952368 2014711 Sulforaphane suppresses mediated activation of NF-kappaB and *induces* apoptosis through activation of reactive oxygen species dependent [caspase-3] . Positive_regulation CASP3 TNF 18952368 2014725 In conclusion , the results of the present study indicate that SFN suppresses induced NF-kappaB activity and *induces* apoptosis through activation of ROS dependent [caspase-3] . Positive_regulation CASP3 TNF 19181934 2043848 Pre-exposure of cells to an IKK inhibitor ( PS-1145 ) prevented *induced* [caspase-3] and PARP cleavage . Positive_regulation CASP3 TNF 19226377 2050416 To assess extrinsic pathways , we measured hepatic expression of death inducing cytokine receptors ( ( TNF-R)1 , TNF-R2 , Fas , and TNFalpha related apoptosis inducing ligand-receptor ( TRAIL-R ) mRNA , TUNEL , [caspase 3] *activation* , liver injury and liver pathology in mice fed a methionine and choline deficient (MCD) diet . Positive_regulation CASP3 TNF 19246452 2062624 CLN2-deficient cells exhibited a defect in *induced* Bid cleavage , release of cytochrome c , and [caspase-9 and -3] activation . Positive_regulation CASP3 TNF 19246452 2062629 Noteworthy , correction of the lysosomal enzyme defect of LINCL fibroblasts using a medium enriched in CLN2 protein enabled restoration of *induced* Bid and [caspase-3] processing and toxicity . Positive_regulation CASP3 TNF 19275968 2072835 LY117018 significantly inhibited *induced* [caspase-3] activation and cell DNA fragmentation levels in bovine carotid artery endothelial cells . Positive_regulation CASP3 TNF 19345705 2094383 Finally , reconstitution of PPT1 activity in mutant cells was accompanied by resensitization to *induced* [caspase] activation and toxicity . Positive_regulation CASP3 TNF 19356108 2007933 Increased adiponectin levels were associated with a decrease in *induced* ICAM-1 and VCAM-1 and [caspase 3] activity in endothelial cells while phosphorylation of eNOS at Ser-1179 increased . Positive_regulation CASP3 TNF 19440308 2078409 Muscle regeneration is , at least in part , regulated by caspase activation , and AVP abrogated dependent [caspase] *activation* . Positive_regulation CASP3 TNF 19555759 2117076 In this paradigm , apoptosis depends on *induced* activation of [caspase-8 and -3] without affecting the activation of caspase-9 . Positive_regulation CASP3 TNF 19555759 2117080 By using knock-out mice for TNF-alpha receptor 1 , we show that the *activation* of both [caspase-3] and -8 by is mediated by TNF-alpha receptor 1 . Positive_regulation CASP3 TNF 19710104 2168130 However , PC supplementation prevented the *induced* DNA fragmentation , cytochrome-c release and [caspase-3] activity in control and CD hepatocytes . Positive_regulation CASP3 TNF 19916860 2166628 Here , the authors show that a single subcutaneous pretreatment of rat with etanercept , a recombinant p75 TNF receptor 2 human immunoglobulin G1 ( IgG1 ) construct , inhibits the hyperoxia induced and *mediated* increase in the expression of TNFalpha receptor , the activation of [caspase 3] in TII cells , and , as an early indicator of lung injury , the capillary-alveolar leakage and granulocyte number in lung lavage . Positive_regulation CASP3 TNF 20080763 2194358 *increased* [caspase-3] activity but activated neither NF-kappaB nor JNK in Tak1-deficient hepatocytes . Positive_regulation CASP3 TNF 20193664 2229262 Furthermore , naofen siRNA , which predominantly knocked down the expression of naofen mRNA , significantly reduced both *induced* [caspase-3] activation and apoptosis in HEK293 cells . Positive_regulation CASP3 TNF 20200974 2299812 Silencing FOXO1 using siRNA in vitro significantly reduced *induced* apoptosis and [caspase] activity in differentiated chondrocytes . Positive_regulation CASP3 TNF 20300563 2230419 and CML-collagen but not control collagen *stimulated* apoptosis , [caspase-3] activity , and FOXO1 DNA binding activity in pericytes . Positive_regulation CASP3 TNF 20360593 2255237 Both and LPS significantly *increased* [caspase-3] , -8 , and -9 activity in term fetal membranes in a time dependent fashion . Positive_regulation CASP3 TNF 20857415 2375596 We found that exposure of MC3T3-E1 osteoblast-like cells to as little as 5 min of OFSS suppressed *induced* activation of [caspase-3] , cleavage of PARP and phosphorylation of histone . Positive_regulation CASP3 TNF 21188622 2402177 Gomisins A and N strongly promoted *induced* cleavage of [caspase-3] and PARP-1 , which are key markers of apoptosis . Positive_regulation CASP3 TNF 21269505 2392746 is also *required* for appropriate regulation of [caspase] genes . Positive_regulation CASP3 TNF 21315038 2393335 Reduction of MC3T3 cell surface cholesterol dramatically inhibited TNFR1 mediated AKT phosphorylation , while did not affect the degradation of I?Ba , activation of ERK or p38 , and processing of [caspase-3] *induced* by . Positive_regulation CASP3 TNF 21609428 2441794 Inhibition of induction using siRNA or inhibition of FasL binding to its receptor by the Nok-1 antibody potently *reduced* LiCl dependent cleavage of [Caspase-3] and increased cell survival . Positive_regulation CASP3 TNF 21893119 2506470 Conversely , *activation* of [caspase] by exogenous required IL-13 , TWEAK , and Fn14 . Positive_regulation CASP3 TNF 21938476 2532758 With 4-MC pretreatment to hyperglycemic rats the following results were noted : ( i ) Decrease in pancreatic NGF level was blocked , ( ii ) Increase in pancreatic TNF-a level and the number of ( + ) beta cell in the islets were prevented , ( iii ) *Increase* in the number of ß cell synthhesized apoptotic Ras effectors that RASSF1 and NORE1 was blocked , ( iv ) While pancreatic lipid peroxidation level decreased , antioxidant molecule glutathione and antioxidant enzymes glutathione peroxidase , catalase and superoxide dismutase activities increased , ( v ) Pancreatic caspase-3 activity and the number of cleaved [caspase-3] ( + ) ß cells were decreased . Positive_regulation CASP3 TNF 22129539 2517510 Both ERK and NF-?B inhibitors decreased *induced* apoptosis of EPCs , as well as the expression of cleaved [caspase-3] and parp . Positive_regulation CASP3 TNF 22214867 2569063 Additionally , in the curative regimen , oleuropein prevented *mediated* activation of hepatic stellate cells , as well as the activation of [caspase-3] . Positive_regulation CASP3 TNF 22471589 2601442 The apoptosis and [caspase-3] activation in *response* to hydrogen peroxide ( H2O2 ) or ( TNF a ) were assessed in the presence or absence of caspase inhibitor Z-VAD-fmk . Positive_regulation CASP3 TNF 22471953 2637169 a-MSH and [ DTRP ( 8 ) ] -?-MSH treatment , for 30 min before TNF-a stimulation , provided a time-and-bell shaped concentration dependent decrease in pro-inflammatory cytokines ( IL-1ß , IL-6 and IL-8 ) release and increased release of the chondroprotective and anti-inflammatory cytokine , IL-10 , whilst decreasing expression of MMP1 , MMP3 , MMP13 genes.a-MSH and [ DTRP ( 8 ) ] -?-MSH treatment also inhibited *induced* [caspase-3/7] activation and chondrocyte death . Positive_regulation CASP3 TNF 22480687 2595224 Raloxifene significantly inhibited *induced* [caspase-3] activation and cell DNA fragmentation levels in chondrocytes . Positive_regulation CASP3 TNF 22567171 2596904 Myocardial rate pressure product ( RPP , LVDP*heart rate ) was markedly decreased in male hearts compared to females in exposure to TNF , which was associated with higher levels of *induced* caspase-8 and [caspase-3] . Positive_regulation CASP3 TNF 22585037 2643395 To further investigate the role and the pathway of Gsdma3 involved in skin keratinocyte apoptosis , using immunofluorescence , RT-PCR , western blot and TUNEL analysis , we showed here that accompanying *induced* apoptosis and [Caspase-3] expression in mouse skin keratinocytes in vivo and in vitro , Gsdma3 expression was significantly upregulated . Positive_regulation CASP3 TNF 22585037 2643396 After Gsdma3 gene mutation , *induced* apoptosis and [Caspase-3] expression in skin keratinocytes were reduced . Positive_regulation CASP3 TNF 22721505 2681850 The antioxidant resveratrol abolished *induced* increase in ROS production and [caspase-3/7] activity , but apoptosis was only partially prevented . Positive_regulation CASP3 TNF 22815072 2676744 Pretreatment with iNOS blocker NG-methyl-L-arginine ( NMA ) attenuated *induced* cell death and [caspase-3] activation . Positive_regulation CASP3 TNF 22869322 2682526 In differentiating human omental adipocytes , incubation with acylated and desacyl ghrelin reduced induced *activation* of caspase-8 and [caspase-3] , and cell death . Positive_regulation CASP3 TNF 22961439 2715959 also *caused* a significant increase in the expression of apoptotic proteins Bax , [Caspase 3] and PARP cleavage , Bnip3 , and TGF-ß , whereas OA modulated these changes . Positive_regulation CASP3 TNF 23180369 2775240 When blocking intracellular CyPA by small interfering RNA in ECs , the effects of *induced* EC apoptosis and proapoptotic protein [caspase-3] expression were significantly inhibited . Positive_regulation CASP3 TNF 23315335 2775437 NECA diminished lactate dehydrogenase ( LDH ) release , *induced* increase of [caspase-3] activity , and cycloheximide ( CHX ) -induced morphological changes typical of apoptosis in PC-3 cells , which were blocked by a selective A2B AR antagonist PSB603 . Positive_regulation CASP3 TNF 23410748 2755191 *induced* [caspase-3] activity was completely inhibited by Z-VAD-fmk , Z-DEVD-fmk , or Z-Asp-CH2-DCB . Positive_regulation CASP3 TNF 23688976 2785590 a-Toxin induced apoptosis of HUV-EC-C cells in a dose- and time dependent manner and caused significantly enhanced expression of and the *activation* of both [caspase-3] and caspase-8 . Positive_regulation CASP3 TNF 23799615 2807961 In addition , SEB and a-toxin were able to induce the expression of and the *activation* of [caspase-3] and -8 in the ECV304 cells . Positive_regulation CASP3 TNF 24039967 2842419 Taken together , these findings indicate that GB induced preferential anti-proliferative and pro-apoptotic signals within B-lineage leukemia/lymphoma cells , as determined by the following biochemical hallmarks of apoptosis : PS externalization , enhanced release of , caspase-8 and [caspase-3] *activation* , PARP-1 cleavage and DNA fragmentation Our observations reveal that GB has potential as an anti-leukemia/lymphoma agent alone or in combination with standard cancer therapies and thus warrants further evaluation in vivo to support these findings . Positive_regulation CASP3 TNF 24259417 2898201 Specifically , we determined that AT-RvD1 prevented mediated [caspase-3] *activation* . Positive_regulation CASP3 TNF 24684347 2935141 Smac-mimetic 1-induced loss of cIAPs correlated with inhibition of mediated NF-?B activation , [caspase] *activation* , and tumor cell killing . Positive_regulation CASP3 TNF 9388267 466832 *induced* apoptosis and [caspase-3-like] activity were also reduced in cultured hepatocytes exposed to 8-bromo-cGMP , and both effects were inhibited by the cGMP dependent kinase inhibitor KT5823 . Positive_regulation CASP3 TNF 9428804 481942 In UA cells , *induced* disruption of mitochondrial membrane potential and [CPP32] activation were abrogated . Positive_regulation CASP3 TNF 9437209 474891 Indeed , shear stress prevented the activation of [caspase-3-like] activity *induced* by H202 or . Positive_regulation CASP3 TNF 9531309 496824 Furthermore , only murine but not IL-1alphabeta *increased* [caspase] activity and apoptosis . Positive_regulation CASP3 TNF 9582369 504233 *induced* antiproliferative effects and [caspase-3] activation , indicators of apoptosis , were also completely suppressed by transfection of cells with Mn-SOD . Positive_regulation CASP3 TNF 9743347 532421 mediated cytotoxicity and *activation* of [caspase-3] were abolished by IL-13 . Positive_regulation CASP3 TNF 9754799 535220 Our findings also showed that *induced* activation of [caspase-3] is inhibited by overexpression of Bcl-xL , suggesting that Bcl-xL acts upstream of caspase activation . Positive_regulation CASP3 TNF 9811886 545952 Given evidence that nitric oxide can prevent *mediated* activation of the pro-apoptotic protease [caspase 3] and protect hepatocytes from cytokine mediated death , cytokine-inducible nitric oxide synthase (iNOS) may be an important hepatoprotective factor in the regenerating liver . Positive_regulation CASP3 TNF 9885230 584455 *induced* [caspase] activation was accompanied by a decrease in the ability of neutrophils to release superoxide anion . Positive_regulation CASP3 TNF 9885230 584481 Granulocyte-macrophage colony stimulating factor inhibited *induced* [caspase] activation and apoptosis , while reversing the diminution in superoxide release . Positive_regulation CASP3 TNF 9973408 596106 We found that treatment of cells with LPS completely abolished mediated cytotoxicity and *activation* of [caspase-3] . Positive_regulation CASP3 TNFSF10 11004677 734966 The apoptotic programme in the sensitive ESFT VH-64 cell line revealed *induced* activation of FLICE/MACH1 ( caspase-8 ) and [CPP32/Yama/apopain] ( caspase-3 ) and processing of the prototype caspase substrate poly ( ADP-ribose ) polymerase . Positive_regulation CASP3 TNFSF10 11568010 864136 *stimulated* [caspase 3] and nitric oxide synthase (NOS) activities , and both pathways cooperate in mediating inhibition of K562 survival/growth . Positive_regulation CASP3 TNFSF10 11585775 866277 The present studies show that these cell lines had similar levels of *induced* activated [caspase-3] as the TRAIL-sensitive lines , but the activated caspase-3 did not degrade substrates downstream of caspase-3 [ inhibitor of caspase activated DNase and poly ( ADP-ribose ) polymerase ] . Positive_regulation CASP3 TNFSF10 11677236 896121 Combining and interferon in vitro , synergistically *induced* apoptosis and [caspase] activation in breast cancer cells . Positive_regulation CASP3 TNFSF10 11782443 900530 Inhibition of caspase-9 activity has no effect on *induced* [caspase-3] activation and cell death , whereas expression of the active form of Smac/DIABLO in the cytosol is sufficient to reconstitute TRAIL sensitivity in Bax-deficient cells . Positive_regulation CASP3 TNFSF10 11911810 924233 Similarly , *activated* [caspase-3] and caspase-7 in control cells but not in cells expressing Bcl-2 or Bcl-xL . Positive_regulation CASP3 TNFSF10 12097388 961383 *activated* caspase-8 and [caspase-3] , but subsequent apoptotic events such as poly ( ADP-ribose ) polymerase cleavage and DNA fragmentation were not observed . Positive_regulation CASP3 TNFSF10 12407100 1036217 Caspase 8 and 10 activation , bid cleavage , cytosolic cytochrome c , and [caspase 3] *activation* by were all increased by the bile acid glycochenodeoxycholate ( GCDCA ) . Positive_regulation CASP3 TNFSF10 12569162 1057210 Using immobilized B7-H1 mAb 's and programmed death 1Ig , we demonstrate that engagement of B7-H1 on CD4 ( + ) T cells costimulates proliferation and secretion of IL-10 , and subsequently leads to programmed cell death , accompanied with upregulated expression of and *activation* of [caspase-3] . Positive_regulation CASP3 TNFSF10 12670926 1076228 *increased* [caspase-3] activity in all of the cells except in DKO cells . Positive_regulation CASP3 TNFSF10 12815069 1103417 In addition , overexpression of cleavage-site mutant c-IAP1 makes cells more resistant to *induced* [caspase] activation . Positive_regulation CASP3 TNFSF10 14644092 1188257 Furthermore , the enhancement extended to *induced* [caspase-activation] . Positive_regulation CASP3 TNFSF10 14690854 1194677 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , Fas , and receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP3 TNFSF10 14739605 1181982 Lower level of constitutive caspase-8 expression in the CEM cell line led to a poor response to both *induced* activation of [caspase-3] and reduction in the mitochondrial membrane potential ( DeltaPsim ) . Positive_regulation CASP3 TNFSF10 14967924 1182630 An in vitro apoptosis inducing assay using cultured granulosa cells prepared from healthy follicles showed that could *activate* [caspase-3] and induce apoptotic cell death in the cells . Positive_regulation CASP3 TNFSF10 15197350 1347061 In this study , we show that TPCK inhibits *induced* [caspase] activity but potentiates wortmannin dependent caspase activity in prostatic carcinoma cell lines . Positive_regulation CASP3 TNFSF10 15558024 1361128 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both promoted by amiloride . Positive_regulation CASP3 TNFSF10 15569667 1368288 Here we demonstrate that human breast cancer cells , but not normal mammary epithelial cells , are dramatically sensitized to *induced* apoptosis and [caspase] activation by peroxisome proliferator activated receptor gamma ( PPARgamma ) agonists of the thiazolidinedione ( TZD ) class . Positive_regulation CASP3 TNFSF10 15607733 1356999 Amiloride enhanced *induced* apoptosis and activation of [caspase-3] and -8 in both cells . Positive_regulation CASP3 TNFSF10 15653686 1381593 Stable expression of wild-type alpha B-crystallin , but not a pseudophosphorylation mutant impaired in its assembly and chaperone function , protects cancer cells from *induced* [caspase-3] activation and apoptosis in vitro . Positive_regulation CASP3 TNFSF10 15767684 1384236 Furthermore , whereas processing of caspase-10 was delayed in TNF treated cells , *triggered* a very rapid activation of [caspase-10 and -3] . Positive_regulation CASP3 TNFSF10 15792357 1386644 Western blot analysis showed that the hypoxia augmented *induced* PARP cleavage as well as the activation of caspase-8 and [caspase-3] , but not caspase-9 . Positive_regulation CASP3 TNFSF10 16103097 1444523 Generation of ROS by CCCP was responsible for *induced* Bax and [caspase] activation because scavenging ROS completely abrogated apical caspase-8 activation and further downstream events leading to cell death . Positive_regulation CASP3 TNFSF10 16103097 1444534 Data suggest that in the presence of mitochondrial derived ROS , *induced* mitochondrial release of Smac/DIABLO and inactivation of X-linked inhibitor of apoptosis through caspase-9 independent activation of [caspase 3] . Positive_regulation CASP3 TNFSF10 16180223 1468111 Further , inhibition of cellular inhibitors of apoptosis protein 1 ( c-IAP1 ) expression by small interfering RNA ( siRNA ) increased mediated [caspase-3] *activation* and apoptosis ; Positive_regulation CASP3 TNFSF10 16362335 1504657 *induced* activation of [caspase-3] , cleavage of Bid and poly-ADP-ribose polymerase , release of cytochrome c , and DNA fragmentation were blocked either by a pan-caspase inhibitor ( zVAD-fmk ) or a CB inhibitor ( CA074Me ) , consistent with the involvement of TRAIL as well as CB in cell death . Positive_regulation CASP3 TNFSF10 16475717 1524139 Inhibition of caspase-2 with the caspase-2 inhibitor z-VDVAD-fmk significantly down-regulated the *induced* [caspase-3] activation , as well as the TRAIL induced cytotoxicity . Positive_regulation CASP3 TNFSF10 17031854 1700277 Here we demonstrated that human prostate cancer cells , but not normal prostate cells , are dramatically sensitized to *induced* apoptosis and [caspase] activation by quercetin . Positive_regulation CASP3 TNFSF10 17031854 1700290 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both enhanced by quercetin . Positive_regulation CASP3 TNFSF10 17273769 1691727 Fenretinide and cooperatively *activated* [caspase-3] , -8 , -10 and -9 and cleavage of Bid and PARP , and this activation was also blocked in the presence of DR5/Fc chimeric protein . Positive_regulation CASP3 TNFSF10 17534891 1773016 Malignant ascites strongly inhibits *induced* [caspase-3] activation and PARP cleavage . Positive_regulation CASP3 TNFSF10 17545549 1751976 We isolated primary tumor cells from 13 astrocytoma and oligoastrocytoma patients of all four WHO grades of malignancy and compared the levels of *induced* apoptosis induction , long-term tumor cell survival , [caspase] , and caspase target cleavage . Positive_regulation CASP3 TNFSF10 17706603 1789070 6-Gingerol facilitated TRAIL induced apoptosis by increasing *induced* [caspase-3/7] activation . Positive_regulation CASP3 TNFSF10 17724141 1822422 Rituximab , a CD20 antibody used to treat certain types of NHL , augmented induced [caspase] *activation* in Ramos RA1 and DoHH2 but not BJAB or SC-1 cells , through modulation of intrinsic rather than extrinsic apoptosis signaling . Positive_regulation CASP3 TNFSF10 17804742 1791209 Although the proteolytic processing of procaspase-3 by TRAIL was partially blocked in glioma cells , cotreatment with silibinin efficiently recovered *induced* [caspase] activation in these cells . Positive_regulation CASP3 TNFSF10 18006822 1827357 In addition to known genes , siRNAs targeting CDK4 , PTGS1 , ALG2 , CLCN3 , IRAK4 , and MAP3K8 altered *induced* [caspase-3] activation responses . Positive_regulation CASP3 TNFSF10 18269677 1865790 In accordance with a previous study of ours , it was found that IgE dependent activation increased *induced* caspase-8 and [caspase-3] cleavage . Positive_regulation CASP3 TNFSF10 18476767 1939003 Whereas *induced* apoptosis in both cell lines through activation of [caspase-3] and caspase-10 , known to link the cell death receptor pathway to the mitochondrial pathway , it triggered increased mitochondrial membrane potential change ( m ) only in HL-60/Vinc cells . Positive_regulation CASP3 TNFSF10 18483385 1910828 Aspirin sensitized human breast cancer cells , but not untransformed human mammary epithelial cells , to induced [caspase] *activation* and apoptosis by a cyclooxygenase-2 independent mechanism . Positive_regulation CASP3 TNFSF10 18665234 1943060 Stable knockdown of bid lead to a pronounced resistance to Fas/CD95- and *induced* [caspase] activation and apoptosis , and significantly increased clonogenic survival . Positive_regulation CASP3 TNFSF10 18829553 1971026 XIAP inhibition combined with TRAIL even breaks Bcl-2 imposed resistance by converting type II cells that depend on the mitochondrial contribution to the death receptor pathway to type I cells in which *induced* activation of [caspase-3] and caspase-9 and apoptosis proceeds irrespective of high Bcl-2 levels . Positive_regulation CASP3 TNFSF10 18980244 1995223 While the proteolytic processing of procaspase-3 by TRAIL was partially blocked in various HCC cells treated with TRAIL alone , co-treatment with quercetin efficiently recovered *induced* [caspase] activation . Positive_regulation CASP3 TNFSF10 19100720 2031210 Bortezomib treatment did not significantly alter plasma membrane amount of DR4 and DR5 but increased *induced* caspase-8 and [caspase-3] activation . Positive_regulation CASP3 TNFSF10 19544400 2136579 *activated* pro-apoptotic [caspase-3] , -7 , and poly-ADP-ribose polymerase and decreased cell numbers of MDA-MB-231 , but had no effect on MCF-7 cells . Positive_regulation CASP3 TNFSF10 19767219 2339237 MiRNA-221 suppression promoted the activation of [caspase 3] *induced* by in T24 cells . Positive_regulation CASP3 TNFSF10 19823077 2184117 SF inhibited *induced* [caspase-3] activation , poly ( ADP-ribose ) polymerase cleavage , and cell death . Positive_regulation CASP3 TNFSF10 19945431 2198960 Caspase 8 or [caspase 3] activities in *response* to were greatly incremented in TOPK depleted cells . Positive_regulation CASP3 TNFSF10 20041491 2241307 IR pretreatment enhances *induced* Bid and [caspase-3] activations . Positive_regulation CASP3 TNFSF10 20400979 2274061 The ability of ovarian cancer ascites to activate Akt and inhibit *induced* cell death and [caspase] activity was decreased by heat inactivation , but was retained in ascites fractions > 5 kDa . Positive_regulation CASP3 TNFSF10 20400979 2274074 These results suggest that ovarian cancer ascites induces FAK and Akt activation in an alphavbeta5 integrin dependent pathway , which confers protection from induced cell death and [caspase] *activation* . Positive_regulation CASP3 TNFSF10 20876774 2368759 Mechanistic studies revealed that 5-FU mediated suppression of c-FLIP results in increased induced recruitment and activation of caspase-8 at the death inducing signalling complex (DISC) , *leading* to [caspase-3] activation and caspase dependent cell death . Positive_regulation CASP3 TNFSF10 21109947 2366197 induced [caspase/p38] *activation* is responsible for the increased catalytic and invasive activities of Akt . Positive_regulation CASP3 TNFSF10 21195158 2396912 In the search of molecular mechanisms , we found that pre-treatment with chrysin could increase *induced* degradation of [caspase 3] , caspase 8 , PARP proteins . Positive_regulation CASP3 TNFSF10 21297379 2410391 however , pre-treatment with bisphosphonates significantly increased *mediated* apoptosis and cellular activation of [caspase-3] . Positive_regulation CASP3 TNFSF10 22555452 2614109 Synergistic *activation* of [caspase-3] , -8 , and -9 by silibinin and was shown by colorimetric assays . Positive_regulation CASP3 TNFSF10 22753701 2622989 Silibinin activated the extrinsic apoptotic pathway in Hep55.1C cells , as attested by the up-regulation of ( TRAIL ) and TRAIL Death receptor 5 (DR5) transcripts , and by the *activation* of [caspase-3] and -8 . Positive_regulation CASP3 TNFSF10 22870360 2641320 This study was designed to measure in vivo effects of propofol , isoflurane and sevoflurane on apoptosis by measuring [caspase-3] and tumor necrosis factor (TNF) related apoptosis *inducing* ligand ( ) blood level as apoptotic markers . Positive_regulation CASP3 TNFSF10 22991197 2734930 We demonstrate that EGFR targeted in combination with BZB *induced* significantly higher [caspase] activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation CASP3 TNFSF10 23180246 2723790 *induces* autophagic protein cleavage through [caspase] activation in melanoma cell lines under arginine deprivation . Positive_regulation CASP3 TNFSF10 23331277 2747073 This increase in bioactivity correlated with the greater ability of to *induce* [caspase-3] activation and is probably due to the increase in local concentration of Apo2L/TRAIL , improving its receptor cross linking efficiency . Positive_regulation CASP3 TNFSF10 23348588 2733979 Instead , *activated* cleavage of caspase-8 and [caspase-3] . Positive_regulation CASP3 TNFSF10 24525736 2914810 Treatment of hepatoma cells with salubrinal , an inhibitor of eIF2a dephosphorylation , enhances *induced* eIF2a phosphorylation , CCAAT/enhancer binding protein homologous protein ( CHOP ) expression and [caspase] activation . Positive_regulation CASP3 TNFSF10 24525736 2914824 Moreover , knockdown of growth arrest and DNA damage-inducible protein 34 ( GADD34 ) , which recruits protein phosphatase 1 to dephosphorylate eIF2a , enhances *induced* eIF2a phosphorylation , CHOP expression , [caspase] activation and apoptosis . Positive_regulation CASP3 TNFSF10 24525736 2914838 Knockdown of CHOP abrogates the stimulation of *induced* [caspase] activation and apoptosis by salubrinal . Positive_regulation CASP4 CAPN8 11449356 836227 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Positive_regulation CASP4 CAPN8 12358768 994363 Calpain inhibitor III ( MDL-28170 ) reduced caspase activation , suggesting that [caspase] activation was *mediated* by . Positive_regulation CASP4 CAPN8 12917442 1151063 Interestingly , the overexpression of parkin induced the activation of an intracellular cysteine protease , calpain , but not [caspase] , and the cytoprotective effect of parkin on alpha-synuclein cytotoxicity was significantly *inhibited* by the presence of inhibitors . Positive_regulation CASP4 CAPN8 16597613 1604260 However , PD-150606 also attenuated caspase-3 activity and apoptosis at 24 h , suggesting *dependent* [caspase] activation . Positive_regulation CASP4 CAPN8 18842681 2028537 CDDP- and adriamycin induced activation of [caspase-4] and -7 appeared to be *mediated* by activity in that it was blocked by the calpain inhibitors calpeptin and PD150606 even when GRP78 was inhibited by siRNA . Positive_regulation CASP4 CAPN8 19931333 2209994 In addition , inhibitors of , which are activated by the Ca ( 2+ ) , also *inhibited* the cleavage of [caspase-4] . Positive_regulation CASP4 CCND1 12480939 1078950 Bcl-2 controls [caspase] activation *following* a p53 dependent death signal . Positive_regulation CASP4 EPHB2 15304372 1322270 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Positive_regulation CASP4 EPHB2 16397410 1512958 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP4 EPHB2 17192846 1701819 These effects were paralleled by disruption of Ras -- > and Akt survival pathways , consequent decreased phosphorylation of both mitochondrial bcl-2 and bad proteins , and [caspase] *activation* . Positive_regulation CASP4 EPHB2 19709398 2139136 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Positive_regulation CASP4 EPHB2 20177944 2236705 This [caspase] activation is *mediated* by phosphorylation of Akt and . Positive_regulation CASP4 EPHB2 21364665 2361108 dependent multiple [caspase] *activation* by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP4 EPHB2 22193398 2543478 Overexpression of ZnT-1 markedly reduced LDH release and caspase activation following I/R. Knockdown of endogenous ZnT-1 augmented the I/R induced release of LDH and increased [caspase] *activation* following I/R. levels were significantly increased following I/R in cells overexpressing ZnT-1 , while knockdown of ZnT-1 reduced phospho-ERK levels . Positive_regulation CASP4 EPHB2 22554503 2590594 The activation of increased XIAP expression and *led* to decreased [caspase] activation . Positive_regulation CASP4 FAS 10213689 608074 *induced* [caspase] denitrosylation . Positive_regulation CASP4 FAS 10352269 617207 In strict contrast , TPA is an ineffective inhibitor when cell death is induced by the potassium ionophore valinomycin , the specific mitochondrial benzodiazepine ligand PK11195 , or by primary [caspase] *activation* by cross linking . Positive_regulation CASP4 FAS 10364198 620467 EGF stimulation of epithelial cells also inhibited induced [caspase] *activation* and the proteolysis of signaling proteins downstream of the EGF receptor , Cbl and Akt/protein kinase B ( Akt ) . Positive_regulation CASP4 FAS 10391681 626716 ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , [caspase] activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation CASP4 FAS 10391681 626732 M3/6 prevented Fas stimulation of JNK , but did not affect mediated [caspase] *activation* or cell death , demonstrating that JNK activation is not required for these processes . Positive_regulation CASP4 FAS 10405325 629343 induced [caspase] *activation* and nuclear apoptosis , however , were unaffected by the depletion of ATP . Positive_regulation CASP4 FAS 10464143 640280 Suppression of induced *activation* of the [caspase] by IL-1beta was diminished by coadministration with D-galactosamine and reversed by coinjection with an excess amount of uridine . Positive_regulation CASP4 FAS 10545115 564282 Taken together , these findings argue that hDaxx promotes sensitivity to Fas from a nuclear location , probably by modulating the transcription of genes involved in induced [caspase] *activation* and apoptosis . Positive_regulation CASP4 FAS 10706558 673181 In conclusion , in vivo stimulation *causes* [caspase] activation , mitochondrial permeability transition ( decreasing the membrane potential and increasing basal respiration ) , mitochondrial matrix expansion ( as shown by matrix herniation ) , outer mitochondrial membrane rupture , and cytochrome c release . Positive_regulation CASP4 FAS 10749152 681131 These results indicate that mediated [caspase] *activation* elicits two independent cellular responses ; Positive_regulation CASP4 FAS 10766189 684362 The caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp ( OMe ) fluoromethyl ketone ( zVADfmk ) , at concentrations that completely prevent apoptosis and [caspase] activation *induced* by ligation of the death receptor , had only a partial protective effect on onconase induced cell death . Positive_regulation CASP4 FAS 11260077 796092 ligation increased apoptosis and decreased colony growth equally in RARS and controls , but *caused* significantly more [caspase] activation in RARS ( P < 0.01 ) . Positive_regulation CASP4 FAS 11278283 819066 Staurosporine activates MST either caspase-dependently or independently , whereas ligation *activates* it only [caspase-dependently] . Positive_regulation CASP4 FAS 11295536 801386 NH ( 2 ) Cl pretreatment significantly inhibited apoptosis and [caspase] activation *induced* by etoposide or camptothecin , a DNA topoisomerase I poison , but not by staurosporine or stimulation . Positive_regulation CASP4 FAS 11322649 807146 Gamma-interferon ( IFN-gamma ) augments apoptotic response to mistletoe lectin-II via upregulation of L expression and [caspase] *activation* in human myeloid U937 cells . Positive_regulation CASP4 FAS 11359796 816301 In isolated GC B cells , cFLIP ( L ) decays rapidly even without ligation , and this *results* in activation of [caspase] activity and apoptosis . Positive_regulation CASP4 FAS 11368434 817077 *induced* [caspase] activity is increased in RARS bone marrow cells . Positive_regulation CASP4 FAS 11536010 854846 We conclude that ( i ) synergistic induction of apoptosis by C2-ceramide and CD95L depend on a cross-talk between the two signal transduction pathways and that ( ii ) C2-ceramide , independently of its sensitizing effects on *dependent* [caspase] activation , is also capable of triggering an apoptotic signaling cascade that is unaffected by zVAD-fmk mediated caspase inhibition , but promoted by high levels of CD95 expression . Positive_regulation CASP4 FAS 11551934 882151 PI3-kinase inhibition sensitized to apoptosis by increasing and accelerating mediated [caspase] *activation* . Positive_regulation CASP4 FAS 11673515 872826 Thus , *induced* initiation of [caspase] activity at the plasma membrane may in some cells result in local proteolysis of submembrane proteins , leading to generation of membrane vesicles that are highly enriched in active caspase 8 . Positive_regulation CASP4 FAS 11698497 878162 Interleukin (IL)-5 and interferon (IFN)-gamma , two cytokines known to prolong eosinophil survival , inhibited mediated apoptosis and [caspase] *activation* but poorly affected the decrease in DeltaPsi ( m ) . Positive_regulation CASP4 FAS 11699200 878332 Recent work has demonstrated that the degree of spontaneous caspase activation in FHL lymphocytes is attenuated in vitro whereas mediated [caspase] *activation* and apoptosis induction remains unmitigated , and FHL can thus be distinguished from the related chronic disorder of immune regulation termed autoimmune lymphoproliferative syndrome or ALPS . Positive_regulation CASP4 FAS 11834943 911166 Lamivudine was also found to stimulate in vitro *induced* apoptosis and [caspase] activation in pre activated T lymphocytes from healthy donors . Positive_regulation CASP4 FAS 12165276 972785 Further investigation of *mediated* [caspase] activities revealed that supplementation of glutamine significantly decreased caspase-3 and caspase-8 activities in activated T cells . Positive_regulation CASP4 FAS 12207331 983592 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Positive_regulation CASP4 FAS 12221075 998192 Enforced expression of GPx1 also resulted in inhibition of induced effector [caspase] *activation* , DNA fragmentation , and apoptotic cell death . Positive_regulation CASP4 FAS 12393561 1035691 Moreover , we have previously reported that G-CSF inhibits induced [caspase] *activation* in sideroblastic anemia ( RARS ) . Positive_regulation CASP4 FAS 12393594 1031524 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Positive_regulation CASP4 FAS 12404126 1009726 Structure-function analysis determined that ATP hydrolysis was necessary for P-gp to confer resistance to induced [caspase] *activation* and cell death . Positive_regulation CASP4 FAS 12444127 1017310 These data indicate that TCR ligation can activate nonapoptotic death programs in WT CD8 ( + ) and CD8 ( + ) T blasts that normally are masked by mediated [caspase] *activation* . Positive_regulation CASP4 FAS 12605597 1079483 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block and etoposide *induced* [caspase] activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation CASP4 FAS 12700647 1082032 Myriocin did not modulate the expression of CD95 or CD95L , instead , it interfered with the early steps of mediated [caspase] *activation* . Positive_regulation CASP4 FAS 12760867 1091400 This effect was correlated with an increase in mediated [caspase] *activation* and enhanced cleavage of the caspase substrate poly ( ADP-ribose ) polymerase . Positive_regulation CASP4 FAS 12760867 1091413 Furthermore , the positive effect on mediated [caspase] *activation* by IFN and ribavirin was confirmed by immunocytochemistry for activated caspase-3 and by immunoblot detection of activated caspase-3 , caspase-7 , and caspase-8 . Positive_regulation CASP4 FAS 12760867 1091426 IFN and ribavirin also enhance mediated [caspase] *activation* , which might in part be responsible for the apoptosis promoting effect of these antiviral compounds . Positive_regulation CASP4 FAS 12850790 1109574 Here , newly developed suicide genes , including *inducible* , inducible [caspase] and CD20 are discussed . Positive_regulation CASP4 FAS 12855571 1149821 Importantly , up-regulation of Gadd45 beta by CD40 precedes *induced* [caspase] activation , as well as up-regulation of other NF-kappa B-controlled inhibitors of apoptosis such as Bcl-xL and c-FLIPL . Positive_regulation CASP4 FAS 12938225 1133112 Co-incubation with cycloheximide partially reversed protection from apoptosis and increased *stimulated* initiator and effector [caspase] activation , suggesting new protein synthesis is necessary to induce protection upstream of caspase activation . Positive_regulation CASP4 FAS 14576776 1156540 The spontaneous death of CD4+ and CD8+ T cells was not prevented by a decoy CD95 receptor or by a broad-spectrum caspase inhibitor ( zVAD-fmk ) , suggesting that this form of cell death is independent of interaction and [caspase] *activation* . Positive_regulation CASP4 FAS 14675162 1189362 Both and anti-CD95 antibodies *triggered* [caspase] activation followed by apoptotic death in fully pro-inflammatory astrocytes , whereas resting cells were totally resistant . Positive_regulation CASP4 FAS 14690854 1194678 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , , and TRAIL receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP4 FAS 15197350 1347075 The inhibitory activity of TPCK was found to be death ligand-specific since TPCK inhibits TRAIL mediated caspase activity but does not affect *induced* [caspase] activity . Positive_regulation CASP4 FAS 15322156 1286763 Consistent with its role in cell death induction , deletion of caspase-8 in hepatocytes protected them from *induced* [caspase] activation and death . Positive_regulation CASP4 FAS 15648737 1350019 These findings suggest that mild hypothermia suppresses *mediated* apoptosis of liver cells by the partial inhibition of signaling events including mitochondrial damage , cytochrome c release , and subsequent apoptosome formation and effector [caspase] activation . Positive_regulation CASP4 FAS 15863130 1401083 Binding of Fas ligand or agonistic anti-Fas antibody to the death receptor can *activate* a [caspase-cascade] resulting in apoptosis . Positive_regulation CASP4 FAS 16120269 895975 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Positive_regulation CASP4 FAS 16384930 1547175 JAK2 mutated PV erythroblasts showed lower levels of induced [caspase] *activation* and incomplete caspase mediated cleavage of the erythroid transcription factor GATA-1 , which was entirely degraded in normal erythroblasts on CD95 stimulation . Positive_regulation CASP4 FAS 16527894 1574405 Simultaneously , mediated [caspase] *activation* precipitates differentiation . Positive_regulation CASP4 FAS 16646028 1557196 stimulation activated NF-kappaB and AP-1 , and this response *required* [caspase] activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation CASP4 FAS 17245429 1690840 The nucleo-cytoplasmic translocation of FLASH requires *induced* [caspase] activation and is facilitated by the Crm1 dependent nuclear export pathway . Positive_regulation CASP4 FAS 17304508 1718979 These results suggest the possible involvement of multiple signaling pathways from the MAPK to the subsequent mitochondria- and/or mediated [caspase] *activation* are potential requirements for PCA induced AGS apoptosis . Positive_regulation CASP4 FAS 18386902 1907140 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , [caspase] activation , and *induction* . Positive_regulation CASP4 FAS 18593565 1953608 induced [caspase] *activation* leads to degradation of gp130 , thereby suppressing IL-6 induced phosphorylation of STAT3 ( Tyr ( 705 ) ) and of tyrosine phosphatase SHP2 ( Tyr ( 580 ) ) . Positive_regulation CASP4 FAS 18948840 2041286 All *led* to a reduced DISC formation and diminished initiator [caspase] activity upon CD95-stimulation , whereas a marked heterogeneity in sensitivity to CD95 induced killing was found . Positive_regulation CASP4 FAS 19002587 1991269 In epithelial cells , induced hierarchic [caspase] *activation* is also linked with DEDD , a member of the DED family that binds to keratin (K) intermediate filaments ( IFs ) . Positive_regulation CASP4 FAS 19111607 2031765 However , recent studies have shown that can *induce* nonapoptotic [caspase independent cell death (CICD)] when caspase activity is inhibited . Positive_regulation CASP4 FAS 19680267 2157904 CD95 is a death receptor whose stimulation by either the physiologic ligand or the agonistic antibodies *leads* to the formation of a multi-molecular complex termed DISC ( death inducing signaling complex ) and the subsequent induction of a [caspase-driven] apoptotic signal . Positive_regulation CASP4 FAS 20876774 2368750 Simultaneous downregulation of c-FLIP ( L ) and c-FLIP ( S ) as well as individual knockdown of either isoform by RNA interference significantly enhances TRAIL ( tumour necrosis factor related apoptosis inducing ligand ) - and *induced* [caspase] activation and caspase dependent apoptosis . Positive_regulation CASP4 FAS 22543586 2750629 Furthermore , loss of RAGE increased expression of the death receptor CD95 ( Fas , Apo-1 ) , dependent [caspase] *activation* and extrinsic apoptosis , whereas NF-kB-p65 nuclear translocation was diminished . Positive_regulation CASP4 FAS 23029562 2681059 Blocking the ERK pathway using a pharmacological inhibitor increased the susceptibility of 661W cells to induced [caspase] *activation* and apoptosis . Positive_regulation CASP4 FAS 23530784 2762300 Various methods to inhibit apoptosis including the cell surface receptor pathway inhibitors , [caspase] *inhibitors* , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation CASP4 FAS 24928990 2946819 Real-time detection of CTL function reveals distinct patterns of [caspase] activation *mediated* by versus granzyme B . Positive_regulation CASP4 FAS 24928990 2946847 Thus , we have used a novel , real-time assay to demonstrate the distinct pattern of [caspase] activation *induced* by granzyme B versus in human and murine CTLs . Positive_regulation CASP4 FAS 9637489 513683 Here , we investigated whether the apoptosis occurring after TCR/CD9 stimulation is associated with a death pathway involving Fas stimulation and mediated [caspase] *activation* as observed in activation induced cell death ( AICD ) . Positive_regulation CASP4 FAS 9694885 524298 Our results demonstrate that whereas mediated activation of caspase 3 *requires* an upstream [caspase] activity that is zVAD-fmk-sensitive , the initial cleavage of caspase 3 during granule mediated cell death is insensitive to zVAD-fmk , suggesting that caspase 3 is cleaved directly by granzyme B in vivo . Positive_regulation CASP4 IL1B 16305880 1485843 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , and interleukin-6 , and *activation* of caspase-1 , caspase-3 and [caspase-11] . Positive_regulation CASP4 MAOA 17883400 1830022 Two unrelated inhibitors *reduced* [caspase] activation . Positive_regulation CASP4 MAP2K6 16397410 1512964 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP4 MAP2K6 16672322 1583727 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* [caspase] activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only caspase activity . Positive_regulation CASP4 MAP2K6 21364665 2361114 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP4 MMP28 13679861 1140547 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP4 MMP7 13679861 1140562 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP4 RNASE1 15620724 1357800 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and induced [caspase] *activation* in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP4 RNASE1 15620724 1358034 We find that and RC-RNase/IFN-gamma *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP4 RNASE7 15620724 1357808 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and induced [caspase] *activation* in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP4 RNASE7 15620724 1358042 We find that and RC-RNase/IFN-gamma *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP4 SPHK1 11238741 791084 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Positive_regulation CASP4 TNF 10425195 632758 *induces* [caspase] activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation CASP4 TNF 10586080 571803 Silymarin also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated induced cytotoxicity and [caspase] *activation* . Positive_regulation CASP4 TNF 10593992 572961 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Positive_regulation CASP4 TNF 10764744 698796 Addition of H ( 2 ) O ( 2 ) prevented induced apoptosis and [caspase] *activation* , an effect prevented by simultaneous addition of catalase . Positive_regulation CASP4 TNF 10820260 694390 *induced* cytotoxicity , [caspase] activation , and lipid peroxidation were also abolished by vesnarinone . Positive_regulation CASP4 TNF 10843709 700176 Resveratrol also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated induced cytotoxicity and [caspase] *activation* . Positive_regulation CASP4 TNF 11228746 581007 induced *activation* of [caspase] activity was blocked by all three types of quenchers . Positive_regulation CASP4 TNF 11847111 912595 mediated [caspase] *activation* and block of differentiation are dependent upon the expression of PW1 , but occur independently of NFkappaB activation . Positive_regulation CASP4 TNF 12036088 949068 *promotes* [caspase] activation and apoptosis in human fetal membranes . Positive_regulation CASP4 TNF 12080044 976115 We also showed that stable overexpression of A20 inhibits apoptosis and [caspase] activation *induced* by . Positive_regulation CASP4 TNF 12431778 1015385 Our results demonstrate that TGF-beta1 can decrease TNF-alpha induced apoptosis in murine osteoblasts at least in part by attenuating *induced* [caspase] gene expression . Positive_regulation CASP4 TNF 12663669 1092596 In the presence of cycloheximide , or interleukin-1 *initiates* [caspase] activation , loss of mitochondrial membrane potential ( DeltaPsi ) , DNA degradation , and nuclear condensation and fragmentation characteristic of apoptotic cell death in human vascular endothelial cells ( EC ) . Positive_regulation CASP4 TNF 12763364 1093892 The latter and mediated [caspase] *activation* was attenuated by prostaglandin E ( 2 ) . Positive_regulation CASP4 TNF 12800192 1098916 The antioxidants N-acetylcysteine , reduced glutathione , lipoic acid and ascorbic acid markedly reduced the enhancing effect of the hormone on induced [caspase] *activation* . Positive_regulation CASP4 TNF 12800192 1098929 The effect of calcitriol on DeltaPsi was mimicked by rotenone , which increased both the drop in DeltaPsi and [caspase] activation *induced* by . Positive_regulation CASP4 TNF 15033766 1184110 The antioxidants N-acetylcysteine , glutathione , lipoic acid , and ascorbic acid markedly reduced the effect of the hormone on induced [caspase] *activation* , attesting to the involvement of reactive oxygen species ( ROS ) in the cross-talk between the hormone and the cytokine . Positive_regulation CASP4 TNF 15283855 1277823 In the *presence* of or endotoxin ( LPS ) , blockade of CD18 ( beta2 chain ) with mAb markedly increased [caspase] activation in PMN on fibrinogen . Positive_regulation CASP4 TNF 15452110 1341975 These mutant cells exhibited a defect in *induced* [caspase] activation , Bid cleavage , and release of cytochrome c . Positive_regulation CASP4 TNF 16532377 1555286 Inhibition of the p38 and/or the JNK death pathways reduced [caspase] activation *induced* by oxidative stress , hyperosmotic shock and . Positive_regulation CASP4 TNF 16631528 1552352 We report that DDC strongly inhibits [caspase] activation , loss of DeltaPsim , and cell death *induced* by or etoposide . Positive_regulation CASP4 TNF 17047073 1635890 Importantly , down-regulation of TRAIL by small interfering RNA silencing decreased mediated Adriamycin induced [caspase] *activation* and apoptosis , and thus enhanced breast cancer cell resistance to Adriamycin . Positive_regulation CASP4 TNF 17125837 1686481 ATD5 could also reduce the TNF-alpha mediated cytotoxicity and inhibit mediated [caspase] *activation* on L929 cells in a dose dependent manner . Positive_regulation CASP4 TNF 17599041 1848495 We have recently shown that *induces* [caspase dependent and -independent] JNK activation and ROS accumulation in cellular FLICE-inhibitory protein ( c-Flip ) ( -/- ) murine embryonic fibroblasts ( MEFs ) . Positive_regulation CASP4 TNF 18023359 1832132 Mitochondrial apoptotic inducer bax , and the suppressor bcl-2 were evaluated using western blotting at 48 h. Results indicated that *increased* [caspase] activities and resulted in a significant ( p = 0.001 ) increase in bax/bcl-2 ratio . Positive_regulation CASP4 TNF 18467439 1938879 However , XIAP small interfering RNA restored *induced* [caspase] signaling and apoptosis in Hec-1A cells ; Positive_regulation CASP4 TNF 18635549 1960075 Evidence is presented that can *stimulate* [caspase-4] and -12 activation in ethanol exposed cells , which cleaves SREBP-1 to a transcriptionally active form to induce the synthesis of lipogenic enzymes and triglycerides . Positive_regulation CASP4 TNF 19345705 2094384 Finally , reconstitution of PPT1 activity in mutant cells was accompanied by resensitization to induced [caspase] *activation* and toxicity . Positive_regulation CASP4 TNF 19440308 2078410 Muscle regeneration is , at least in part , regulated by caspase activation , and AVP abrogated *dependent* [caspase] activation . Positive_regulation CASP4 TNF 20200974 2299813 Silencing FOXO1 using siRNA in vitro significantly reduced *induced* apoptosis and [caspase] activity in differentiated chondrocytes . Positive_regulation CASP4 TNF 21269505 2392747 is also *required* for appropriate regulation of [caspase] genes . Positive_regulation CASP4 TNF 21893119 2506474 Conversely , *activation* of [caspase] by exogenous required IL-13 , TWEAK , and Fn14 . Positive_regulation CASP4 TNF 24684347 2935142 Smac-mimetic 1-induced loss of cIAPs correlated with inhibition of mediated NF-?B activation , [caspase] *activation* , and tumor cell killing . Positive_regulation CASP4 TNF 9531309 496826 Furthermore , only murine but not IL-1alphabeta *increased* [caspase] activity and apoptosis . Positive_regulation CASP4 TNF 9885230 584456 induced [caspase] *activation* was accompanied by a decrease in the ability of neutrophils to release superoxide anion . Positive_regulation CASP4 TNF 9885230 584482 Granulocyte-macrophage colony stimulating factor inhibited induced [caspase] *activation* and apoptosis , while reversing the diminution in superoxide release . Positive_regulation CASP4 TNFSF10 11677236 896122 Combining and interferon in vitro , synergistically *induced* apoptosis and [caspase] activation in breast cancer cells . Positive_regulation CASP4 TNFSF10 12815069 1103418 In addition , overexpression of cleavage-site mutant c-IAP1 makes cells more resistant to induced [caspase] *activation* . Positive_regulation CASP4 TNFSF10 14644092 1188258 Furthermore , the enhancement extended to *induced* [caspase-activation] . Positive_regulation CASP4 TNFSF10 14690854 1194679 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , Fas , and receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP4 TNFSF10 15197350 1347062 In this study , we show that TPCK inhibits *induced* [caspase] activity but potentiates wortmannin dependent caspase activity in prostatic carcinoma cell lines . Positive_regulation CASP4 TNFSF10 15558024 1361129 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both promoted by amiloride . Positive_regulation CASP4 TNFSF10 15569667 1368289 Here we demonstrate that human breast cancer cells , but not normal mammary epithelial cells , are dramatically sensitized to induced apoptosis and [caspase] *activation* by peroxisome proliferator activated receptor gamma ( PPARgamma ) agonists of the thiazolidinedione ( TZD ) class . Positive_regulation CASP4 TNFSF10 16103097 1444524 Generation of ROS by CCCP was responsible for *induced* Bax and [caspase] activation because scavenging ROS completely abrogated apical caspase-8 activation and further downstream events leading to cell death . Positive_regulation CASP4 TNFSF10 17031854 1700278 Here we demonstrated that human prostate cancer cells , but not normal prostate cells , are dramatically sensitized to induced apoptosis and [caspase] *activation* by quercetin . Positive_regulation CASP4 TNFSF10 17031854 1700291 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both enhanced by quercetin . Positive_regulation CASP4 TNFSF10 17545549 1751977 We isolated primary tumor cells from 13 astrocytoma and oligoastrocytoma patients of all four WHO grades of malignancy and compared the levels of *induced* apoptosis induction , long-term tumor cell survival , [caspase] , and caspase target cleavage . Positive_regulation CASP4 TNFSF10 17724141 1822423 Rituximab , a CD20 antibody used to treat certain types of NHL , augmented *induced* [caspase] activation in Ramos RA1 and DoHH2 but not BJAB or SC-1 cells , through modulation of intrinsic rather than extrinsic apoptosis signaling . Positive_regulation CASP4 TNFSF10 17804742 1791210 Although the proteolytic processing of procaspase-3 by TRAIL was partially blocked in glioma cells , cotreatment with silibinin efficiently recovered induced [caspase] *activation* in these cells . Positive_regulation CASP4 TNFSF10 18483385 1910829 Aspirin sensitized human breast cancer cells , but not untransformed human mammary epithelial cells , to *induced* [caspase] activation and apoptosis by a cyclooxygenase-2 independent mechanism . Positive_regulation CASP4 TNFSF10 18665234 1943061 Stable knockdown of bid lead to a pronounced resistance to Fas/CD95- and *induced* [caspase] activation and apoptosis , and significantly increased clonogenic survival . Positive_regulation CASP4 TNFSF10 18980244 1995224 While the proteolytic processing of procaspase-3 by TRAIL was partially blocked in various HCC cells treated with TRAIL alone , co-treatment with quercetin efficiently recovered induced [caspase] *activation* . Positive_regulation CASP4 TNFSF10 20400979 2274062 The ability of ovarian cancer ascites to activate Akt and inhibit *induced* cell death and [caspase] activity was decreased by heat inactivation , but was retained in ascites fractions > 5 kDa . Positive_regulation CASP4 TNFSF10 20400979 2274075 These results suggest that ovarian cancer ascites induces FAK and Akt activation in an alphavbeta5 integrin dependent pathway , which confers protection from *induced* cell death and [caspase] activation . Positive_regulation CASP4 TNFSF10 20514521 2319955 This appeared to be mediated by caspase-3 , in that caspase-4 was activated later than caspase-8 , -9 , and -3 , and that inhibition of caspase-3 blocked induced [caspase-4] *activation* . Positive_regulation CASP4 TNFSF10 21109947 2366198 *induced* [caspase/p38] activation is responsible for the increased catalytic and invasive activities of Akt . Positive_regulation CASP4 TNFSF10 22991197 2734931 We demonstrate that EGFR targeted in combination with BZB *induced* significantly higher [caspase] activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation CASP4 TNFSF10 23180246 2723791 *induces* autophagic protein cleavage through [caspase] activation in melanoma cell lines under arginine deprivation . Positive_regulation CASP4 TNFSF10 24525736 2914811 Treatment of hepatoma cells with salubrinal , an inhibitor of eIF2a dephosphorylation , enhances induced eIF2a phosphorylation , CCAAT/enhancer binding protein homologous protein ( CHOP ) expression and [caspase] *activation* . Positive_regulation CASP4 TNFSF10 24525736 2914825 Moreover , knockdown of growth arrest and DNA damage-inducible protein 34 ( GADD34 ) , which recruits protein phosphatase 1 to dephosphorylate eIF2a , enhances *induced* eIF2a phosphorylation , CHOP expression , [caspase] activation and apoptosis . Positive_regulation CASP4 TNFSF10 24525736 2914839 Knockdown of CHOP abrogates the stimulation of induced [caspase] *activation* and apoptosis by salubrinal . Positive_regulation CASP5 CAPN8 11449356 836241 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Positive_regulation CASP5 CAPN8 12358768 994378 Calpain inhibitor III ( MDL-28170 ) reduced caspase activation , suggesting that [caspase] activation was *mediated* by . Positive_regulation CASP5 CAPN8 12917442 1151077 Interestingly , the overexpression of parkin induced the activation of an intracellular cysteine protease , calpain , but not [caspase] , and the cytoprotective effect of parkin on alpha-synuclein cytotoxicity was significantly *inhibited* by the presence of inhibitors . Positive_regulation CASP5 CAPN8 16597613 1604274 However , PD-150606 also attenuated caspase-3 activity and apoptosis at 24 h , suggesting *dependent* [caspase] activation . Positive_regulation CASP5 CCND1 12480939 1078952 Bcl-2 controls [caspase] activation *following* a p53 dependent death signal . Positive_regulation CASP5 EPHB2 15304372 1322271 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Positive_regulation CASP5 EPHB2 16397410 1512966 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP5 EPHB2 17192846 1701820 These effects were paralleled by disruption of Ras -- > and Akt survival pathways , consequent decreased phosphorylation of both mitochondrial bcl-2 and bad proteins , and [caspase] *activation* . Positive_regulation CASP5 EPHB2 19709398 2139138 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Positive_regulation CASP5 EPHB2 20177944 2236709 This [caspase] activation is *mediated* by phosphorylation of Akt and . Positive_regulation CASP5 EPHB2 21364665 2361116 dependent multiple [caspase] *activation* by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP5 EPHB2 22193398 2543481 Overexpression of ZnT-1 markedly reduced LDH release and caspase activation following I/R. Knockdown of endogenous ZnT-1 augmented the I/R induced release of LDH and increased [caspase] *activation* following I/R. levels were significantly increased following I/R in cells overexpressing ZnT-1 , while knockdown of ZnT-1 reduced phospho-ERK levels . Positive_regulation CASP5 EPHB2 22554503 2590595 The activation of increased XIAP expression and *led* to decreased [caspase] activation . Positive_regulation CASP5 FAS 10213689 608075 *induced* [caspase] denitrosylation . Positive_regulation CASP5 FAS 10352269 617208 In strict contrast , TPA is an ineffective inhibitor when cell death is induced by the potassium ionophore valinomycin , the specific mitochondrial benzodiazepine ligand PK11195 , or by primary [caspase] *activation* by cross linking . Positive_regulation CASP5 FAS 10364198 620468 EGF stimulation of epithelial cells also inhibited induced [caspase] *activation* and the proteolysis of signaling proteins downstream of the EGF receptor , Cbl and Akt/protein kinase B ( Akt ) . Positive_regulation CASP5 FAS 10391681 626717 ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , [caspase] activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation CASP5 FAS 10391681 626733 M3/6 prevented Fas stimulation of JNK , but did not affect mediated [caspase] *activation* or cell death , demonstrating that JNK activation is not required for these processes . Positive_regulation CASP5 FAS 10405325 629344 *induced* [caspase] activation and nuclear apoptosis , however , were unaffected by the depletion of ATP . Positive_regulation CASP5 FAS 10464143 640281 Suppression of *induced* activation of the [caspase] by IL-1beta was diminished by coadministration with D-galactosamine and reversed by coinjection with an excess amount of uridine . Positive_regulation CASP5 FAS 10545115 564283 Taken together , these findings argue that hDaxx promotes sensitivity to Fas from a nuclear location , probably by modulating the transcription of genes involved in induced [caspase] *activation* and apoptosis . Positive_regulation CASP5 FAS 10706558 673182 In conclusion , in vivo stimulation *causes* [caspase] activation , mitochondrial permeability transition ( decreasing the membrane potential and increasing basal respiration ) , mitochondrial matrix expansion ( as shown by matrix herniation ) , outer mitochondrial membrane rupture , and cytochrome c release . Positive_regulation CASP5 FAS 10749152 681132 These results indicate that mediated [caspase] *activation* elicits two independent cellular responses ; Positive_regulation CASP5 FAS 10766189 684363 The caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp ( OMe ) fluoromethyl ketone ( zVADfmk ) , at concentrations that completely prevent apoptosis and [caspase] activation *induced* by ligation of the death receptor , had only a partial protective effect on onconase induced cell death . Positive_regulation CASP5 FAS 11260077 796093 ligation increased apoptosis and decreased colony growth equally in RARS and controls , but *caused* significantly more [caspase] activation in RARS ( P < 0.01 ) . Positive_regulation CASP5 FAS 11278283 819067 Staurosporine activates MST either caspase-dependently or independently , whereas ligation *activates* it only [caspase-dependently] . Positive_regulation CASP5 FAS 11295536 801387 NH ( 2 ) Cl pretreatment significantly inhibited apoptosis and [caspase] activation *induced* by etoposide or camptothecin , a DNA topoisomerase I poison , but not by staurosporine or stimulation . Positive_regulation CASP5 FAS 11322649 807148 Gamma-interferon ( IFN-gamma ) augments apoptotic response to mistletoe lectin-II via upregulation of L expression and [caspase] *activation* in human myeloid U937 cells . Positive_regulation CASP5 FAS 11359796 816302 In isolated GC B cells , cFLIP ( L ) decays rapidly even without ligation , and this *results* in activation of [caspase] activity and apoptosis . Positive_regulation CASP5 FAS 11368434 817078 *induced* [caspase] activity is increased in RARS bone marrow cells . Positive_regulation CASP5 FAS 11536010 854847 We conclude that ( i ) synergistic induction of apoptosis by C2-ceramide and CD95L depend on a cross-talk between the two signal transduction pathways and that ( ii ) C2-ceramide , independently of its sensitizing effects on dependent [caspase] *activation* , is also capable of triggering an apoptotic signaling cascade that is unaffected by zVAD-fmk mediated caspase inhibition , but promoted by high levels of CD95 expression . Positive_regulation CASP5 FAS 11551934 882152 PI3-kinase inhibition sensitized to apoptosis by increasing and accelerating mediated [caspase] *activation* . Positive_regulation CASP5 FAS 11673515 872827 Thus , *induced* initiation of [caspase] activity at the plasma membrane may in some cells result in local proteolysis of submembrane proteins , leading to generation of membrane vesicles that are highly enriched in active caspase 8 . Positive_regulation CASP5 FAS 11698497 878163 Interleukin (IL)-5 and interferon (IFN)-gamma , two cytokines known to prolong eosinophil survival , inhibited *mediated* apoptosis and [caspase] activation but poorly affected the decrease in DeltaPsi ( m ) . Positive_regulation CASP5 FAS 11699200 878333 Recent work has demonstrated that the degree of spontaneous caspase activation in FHL lymphocytes is attenuated in vitro whereas mediated [caspase] *activation* and apoptosis induction remains unmitigated , and FHL can thus be distinguished from the related chronic disorder of immune regulation termed autoimmune lymphoproliferative syndrome or ALPS . Positive_regulation CASP5 FAS 11834943 911167 Lamivudine was also found to stimulate in vitro induced apoptosis and [caspase] *activation* in pre activated T lymphocytes from healthy donors . Positive_regulation CASP5 FAS 12165276 972786 Further investigation of *mediated* [caspase] activities revealed that supplementation of glutamine significantly decreased caspase-3 and caspase-8 activities in activated T cells . Positive_regulation CASP5 FAS 12207331 983593 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Positive_regulation CASP5 FAS 12221075 998194 Enforced expression of GPx1 also resulted in inhibition of induced effector [caspase] *activation* , DNA fragmentation , and apoptotic cell death . Positive_regulation CASP5 FAS 12393561 1035692 Moreover , we have previously reported that G-CSF inhibits *induced* [caspase] activation in sideroblastic anemia ( RARS ) . Positive_regulation CASP5 FAS 12393594 1031525 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Positive_regulation CASP5 FAS 12404126 1009727 Structure-function analysis determined that ATP hydrolysis was necessary for P-gp to confer resistance to *induced* [caspase] activation and cell death . Positive_regulation CASP5 FAS 12444127 1017311 These data indicate that TCR ligation can activate nonapoptotic death programs in WT CD8 ( + ) and CD8 ( + ) T blasts that normally are masked by mediated [caspase] *activation* . Positive_regulation CASP5 FAS 12605597 1079484 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block and etoposide *induced* [caspase] activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation CASP5 FAS 12700647 1082033 Myriocin did not modulate the expression of CD95 or CD95L , instead , it interfered with the early steps of mediated [caspase] *activation* . Positive_regulation CASP5 FAS 12760867 1091401 This effect was correlated with an increase in mediated [caspase] *activation* and enhanced cleavage of the caspase substrate poly ( ADP-ribose ) polymerase . Positive_regulation CASP5 FAS 12760867 1091414 Furthermore , the positive effect on mediated [caspase] *activation* by IFN and ribavirin was confirmed by immunocytochemistry for activated caspase-3 and by immunoblot detection of activated caspase-3 , caspase-7 , and caspase-8 . Positive_regulation CASP5 FAS 12760867 1091427 IFN and ribavirin also enhance mediated [caspase] *activation* , which might in part be responsible for the apoptosis promoting effect of these antiviral compounds . Positive_regulation CASP5 FAS 12850790 1109575 Here , newly developed suicide genes , including *inducible* , inducible [caspase] and CD20 are discussed . Positive_regulation CASP5 FAS 12855571 1149822 Importantly , up-regulation of Gadd45 beta by CD40 precedes induced [caspase] *activation* , as well as up-regulation of other NF-kappa B-controlled inhibitors of apoptosis such as Bcl-xL and c-FLIPL . Positive_regulation CASP5 FAS 12938225 1133113 Co-incubation with cycloheximide partially reversed protection from apoptosis and increased *stimulated* initiator and effector [caspase] activation , suggesting new protein synthesis is necessary to induce protection upstream of caspase activation . Positive_regulation CASP5 FAS 14576776 1156541 The spontaneous death of CD4+ and CD8+ T cells was not prevented by a decoy CD95 receptor or by a broad-spectrum caspase inhibitor ( zVAD-fmk ) , suggesting that this form of cell death is independent of interaction and [caspase] *activation* . Positive_regulation CASP5 FAS 14675162 1189363 Both and anti-CD95 antibodies *triggered* [caspase] activation followed by apoptotic death in fully pro-inflammatory astrocytes , whereas resting cells were totally resistant . Positive_regulation CASP5 FAS 14690854 1194680 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , , and TRAIL receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP5 FAS 15197350 1347076 The inhibitory activity of TPCK was found to be death ligand-specific since TPCK inhibits TRAIL mediated caspase activity but does not affect *induced* [caspase] activity . Positive_regulation CASP5 FAS 15322156 1286764 Consistent with its role in cell death induction , deletion of caspase-8 in hepatocytes protected them from induced [caspase] *activation* and death . Positive_regulation CASP5 FAS 15648737 1350020 These findings suggest that mild hypothermia suppresses mediated apoptosis of liver cells by the partial inhibition of signaling events including mitochondrial damage , cytochrome c release , and subsequent apoptosome formation and effector [caspase] *activation* . Positive_regulation CASP5 FAS 15863130 1401084 Binding of Fas ligand or agonistic anti-Fas antibody to the death receptor can *activate* a [caspase-cascade] resulting in apoptosis . Positive_regulation CASP5 FAS 16120269 895976 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Positive_regulation CASP5 FAS 16384930 1547176 JAK2 mutated PV erythroblasts showed lower levels of *induced* [caspase] activation and incomplete caspase mediated cleavage of the erythroid transcription factor GATA-1 , which was entirely degraded in normal erythroblasts on CD95 stimulation . Positive_regulation CASP5 FAS 16527894 1574406 Simultaneously , mediated [caspase] *activation* precipitates differentiation . Positive_regulation CASP5 FAS 16646028 1557200 stimulation activated NF-kappaB and AP-1 , and this response *required* [caspase] activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation CASP5 FAS 17245429 1690841 The nucleo-cytoplasmic translocation of FLASH requires induced [caspase] *activation* and is facilitated by the Crm1 dependent nuclear export pathway . Positive_regulation CASP5 FAS 17304508 1718980 These results suggest the possible involvement of multiple signaling pathways from the MAPK to the subsequent mitochondria- and/or mediated [caspase] *activation* are potential requirements for PCA induced AGS apoptosis . Positive_regulation CASP5 FAS 18386902 1907141 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , [caspase] activation , and *induction* . Positive_regulation CASP5 FAS 18593565 1953609 *induced* [caspase] activation leads to degradation of gp130 , thereby suppressing IL-6 induced phosphorylation of STAT3 ( Tyr ( 705 ) ) and of tyrosine phosphatase SHP2 ( Tyr ( 580 ) ) . Positive_regulation CASP5 FAS 18948840 2041287 All *led* to a reduced DISC formation and diminished initiator [caspase] activity upon CD95-stimulation , whereas a marked heterogeneity in sensitivity to CD95 induced killing was found . Positive_regulation CASP5 FAS 19002587 1991270 In epithelial cells , induced hierarchic [caspase] *activation* is also linked with DEDD , a member of the DED family that binds to keratin (K) intermediate filaments ( IFs ) . Positive_regulation CASP5 FAS 19111607 2031766 However , recent studies have shown that can *induce* nonapoptotic [caspase independent cell death (CICD)] when caspase activity is inhibited . Positive_regulation CASP5 FAS 19680267 2157905 CD95 is a death receptor whose stimulation by either the physiologic ligand or the agonistic antibodies *leads* to the formation of a multi-molecular complex termed DISC ( death inducing signaling complex ) and the subsequent induction of a [caspase-driven] apoptotic signal . Positive_regulation CASP5 FAS 20876774 2368751 Simultaneous downregulation of c-FLIP ( L ) and c-FLIP ( S ) as well as individual knockdown of either isoform by RNA interference significantly enhances TRAIL ( tumour necrosis factor related apoptosis inducing ligand ) - and *induced* [caspase] activation and caspase dependent apoptosis . Positive_regulation CASP5 FAS 22543586 2750630 Furthermore , loss of RAGE increased expression of the death receptor CD95 ( Fas , Apo-1 ) , *dependent* [caspase] activation and extrinsic apoptosis , whereas NF-kB-p65 nuclear translocation was diminished . Positive_regulation CASP5 FAS 23029562 2681060 Blocking the ERK pathway using a pharmacological inhibitor increased the susceptibility of 661W cells to *induced* [caspase] activation and apoptosis . Positive_regulation CASP5 FAS 23530784 2762301 Various methods to inhibit apoptosis including the cell surface receptor pathway inhibitors , [caspase] *inhibitors* , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation CASP5 FAS 24928990 2946821 Real-time detection of CTL function reveals distinct patterns of [caspase] activation *mediated* by versus granzyme B . Positive_regulation CASP5 FAS 24928990 2946849 Thus , we have used a novel , real-time assay to demonstrate the distinct pattern of [caspase] activation *induced* by granzyme B versus in human and murine CTLs . Positive_regulation CASP5 FAS 9637489 513684 Here , we investigated whether the apoptosis occurring after TCR/CD9 stimulation is associated with a death pathway involving Fas stimulation and mediated [caspase] *activation* as observed in activation induced cell death ( AICD ) . Positive_regulation CASP5 FAS 9694885 524300 Our results demonstrate that whereas mediated activation of caspase 3 *requires* an upstream [caspase] activity that is zVAD-fmk-sensitive , the initial cleavage of caspase 3 during granule mediated cell death is insensitive to zVAD-fmk , suggesting that caspase 3 is cleaved directly by granzyme B in vivo . Positive_regulation CASP5 IL1B 16305880 1485859 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , and interleukin-6 , and *activation* of caspase-1 , caspase-3 and [caspase-11] . Positive_regulation CASP5 MAOA 17883400 1830023 Two unrelated inhibitors *reduced* [caspase] activation . Positive_regulation CASP5 MAP2K6 16397410 1512972 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP5 MAP2K6 16672322 1583736 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* [caspase] activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only caspase activity . Positive_regulation CASP5 MAP2K6 21364665 2361122 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP5 MMP28 13679861 1140569 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP5 MMP7 13679861 1140584 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP5 RNASE1 15620724 1357813 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and induced [caspase] *activation* in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP5 RNASE1 15620724 1358047 We find that and RC-RNase/IFN-gamma *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP5 RNASE7 15620724 1357821 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and induced [caspase] *activation* in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP5 RNASE7 15620724 1358055 We find that and RC-RNase/IFN-gamma *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP5 SPHK1 11238741 791086 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Positive_regulation CASP5 TNF 10425195 632759 *induces* [caspase] activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation CASP5 TNF 10586080 571804 Silymarin also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated *induced* cytotoxicity and [caspase] activation . Positive_regulation CASP5 TNF 10593992 572962 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Positive_regulation CASP5 TNF 10764744 698797 Addition of H ( 2 ) O ( 2 ) prevented *induced* apoptosis and [caspase] activation , an effect prevented by simultaneous addition of catalase . Positive_regulation CASP5 TNF 10820260 694391 induced cytotoxicity , [caspase] *activation* , and lipid peroxidation were also abolished by vesnarinone . Positive_regulation CASP5 TNF 10843709 700177 Resveratrol also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated *induced* cytotoxicity and [caspase] activation . Positive_regulation CASP5 TNF 11228746 581008 induced *activation* of [caspase] activity was blocked by all three types of quenchers . Positive_regulation CASP5 TNF 11847111 912596 mediated [caspase] *activation* and block of differentiation are dependent upon the expression of PW1 , but occur independently of NFkappaB activation . Positive_regulation CASP5 TNF 12036088 949069 *promotes* [caspase] activation and apoptosis in human fetal membranes . Positive_regulation CASP5 TNF 12080044 976118 We also showed that stable overexpression of A20 inhibits apoptosis and [caspase] activation *induced* by . Positive_regulation CASP5 TNF 12431778 1015386 Our results demonstrate that TGF-beta1 can decrease TNF-alpha induced apoptosis in murine osteoblasts at least in part by attenuating *induced* [caspase] gene expression . Positive_regulation CASP5 TNF 12663669 1092624 In the presence of cycloheximide , or interleukin-1 *initiates* [caspase] activation , loss of mitochondrial membrane potential ( DeltaPsi ) , DNA degradation , and nuclear condensation and fragmentation characteristic of apoptotic cell death in human vascular endothelial cells ( EC ) . Positive_regulation CASP5 TNF 12763364 1093893 The latter and mediated [caspase] *activation* was attenuated by prostaglandin E ( 2 ) . Positive_regulation CASP5 TNF 12800192 1098917 The antioxidants N-acetylcysteine , reduced glutathione , lipoic acid and ascorbic acid markedly reduced the enhancing effect of the hormone on *induced* [caspase] activation . Positive_regulation CASP5 TNF 12800192 1098930 The effect of calcitriol on DeltaPsi was mimicked by rotenone , which increased both the drop in DeltaPsi and [caspase] activation *induced* by . Positive_regulation CASP5 TNF 15033766 1184111 The antioxidants N-acetylcysteine , glutathione , lipoic acid , and ascorbic acid markedly reduced the effect of the hormone on *induced* [caspase] activation , attesting to the involvement of reactive oxygen species ( ROS ) in the cross-talk between the hormone and the cytokine . Positive_regulation CASP5 TNF 15283855 1277824 In the *presence* of or endotoxin ( LPS ) , blockade of CD18 ( beta2 chain ) with mAb markedly increased [caspase] activation in PMN on fibrinogen . Positive_regulation CASP5 TNF 15452110 1341976 These mutant cells exhibited a defect in induced [caspase] *activation* , Bid cleavage , and release of cytochrome c . Positive_regulation CASP5 TNF 16532377 1555287 Inhibition of the p38 and/or the JNK death pathways reduced [caspase] activation *induced* by oxidative stress , hyperosmotic shock and . Positive_regulation CASP5 TNF 16631528 1552353 We report that DDC strongly inhibits [caspase] activation , loss of DeltaPsim , and cell death *induced* by or etoposide . Positive_regulation CASP5 TNF 17047073 1635891 Importantly , down-regulation of TRAIL by small interfering RNA silencing decreased mediated Adriamycin induced [caspase] *activation* and apoptosis , and thus enhanced breast cancer cell resistance to Adriamycin . Positive_regulation CASP5 TNF 17125837 1686482 ATD5 could also reduce the TNF-alpha mediated cytotoxicity and inhibit mediated [caspase] *activation* on L929 cells in a dose dependent manner . Positive_regulation CASP5 TNF 17599041 1848496 We have recently shown that *induces* [caspase dependent and -independent] JNK activation and ROS accumulation in cellular FLICE-inhibitory protein ( c-Flip ) ( -/- ) murine embryonic fibroblasts ( MEFs ) . Positive_regulation CASP5 TNF 17725714 1789914 [Caspase-5] gene expression was *induced* by , which was inhibited by the small hairpin RNA mediated down-regulation of p73 . Positive_regulation CASP5 TNF 18023359 1832133 Mitochondrial apoptotic inducer bax , and the suppressor bcl-2 were evaluated using western blotting at 48 h. Results indicated that *increased* [caspase] activities and resulted in a significant ( p = 0.001 ) increase in bax/bcl-2 ratio . Positive_regulation CASP5 TNF 18467439 1938880 However , XIAP small interfering RNA restored *induced* [caspase] signaling and apoptosis in Hec-1A cells ; Positive_regulation CASP5 TNF 19345705 2094385 Finally , reconstitution of PPT1 activity in mutant cells was accompanied by resensitization to *induced* [caspase] activation and toxicity . Positive_regulation CASP5 TNF 19440308 2078411 Muscle regeneration is , at least in part , regulated by caspase activation , and AVP abrogated dependent [caspase] *activation* . Positive_regulation CASP5 TNF 20200974 2299814 Silencing FOXO1 using siRNA in vitro significantly reduced *induced* apoptosis and [caspase] activity in differentiated chondrocytes . Positive_regulation CASP5 TNF 21269505 2392748 is also *required* for appropriate regulation of [caspase] genes . Positive_regulation CASP5 TNF 21893119 2506478 Conversely , *activation* of [caspase] by exogenous required IL-13 , TWEAK , and Fn14 . Positive_regulation CASP5 TNF 24684347 2935143 Smac-mimetic 1-induced loss of cIAPs correlated with inhibition of mediated NF-?B activation , [caspase] *activation* , and tumor cell killing . Positive_regulation CASP5 TNF 9531309 496828 Furthermore , only murine but not IL-1alphabeta *increased* [caspase] activity and apoptosis . Positive_regulation CASP5 TNF 9885230 584457 *induced* [caspase] activation was accompanied by a decrease in the ability of neutrophils to release superoxide anion . Positive_regulation CASP5 TNF 9885230 584483 Granulocyte-macrophage colony stimulating factor inhibited *induced* [caspase] activation and apoptosis , while reversing the diminution in superoxide release . Positive_regulation CASP5 TNFSF10 11677236 896123 Combining and interferon in vitro , synergistically *induced* apoptosis and [caspase] activation in breast cancer cells . Positive_regulation CASP5 TNFSF10 12815069 1103419 In addition , overexpression of cleavage-site mutant c-IAP1 makes cells more resistant to *induced* [caspase] activation . Positive_regulation CASP5 TNFSF10 14644092 1188259 Furthermore , the enhancement extended to *induced* [caspase-activation] . Positive_regulation CASP5 TNFSF10 14690854 1194681 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , Fas , and receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP5 TNFSF10 15197350 1347063 In this study , we show that TPCK inhibits *induced* [caspase] activity but potentiates wortmannin dependent caspase activity in prostatic carcinoma cell lines . Positive_regulation CASP5 TNFSF10 15558024 1361130 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both promoted by amiloride . Positive_regulation CASP5 TNFSF10 15569667 1368290 Here we demonstrate that human breast cancer cells , but not normal mammary epithelial cells , are dramatically sensitized to *induced* apoptosis and [caspase] activation by peroxisome proliferator activated receptor gamma ( PPARgamma ) agonists of the thiazolidinedione ( TZD ) class . Positive_regulation CASP5 TNFSF10 16103097 1444525 Generation of ROS by CCCP was responsible for *induced* Bax and [caspase] activation because scavenging ROS completely abrogated apical caspase-8 activation and further downstream events leading to cell death . Positive_regulation CASP5 TNFSF10 17031854 1700279 Here we demonstrated that human prostate cancer cells , but not normal prostate cells , are dramatically sensitized to *induced* apoptosis and [caspase] activation by quercetin . Positive_regulation CASP5 TNFSF10 17031854 1700292 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both enhanced by quercetin . Positive_regulation CASP5 TNFSF10 17545549 1751978 We isolated primary tumor cells from 13 astrocytoma and oligoastrocytoma patients of all four WHO grades of malignancy and compared the levels of *induced* apoptosis induction , long-term tumor cell survival , [caspase] , and caspase target cleavage . Positive_regulation CASP5 TNFSF10 17724141 1822424 Rituximab , a CD20 antibody used to treat certain types of NHL , augmented induced [caspase] *activation* in Ramos RA1 and DoHH2 but not BJAB or SC-1 cells , through modulation of intrinsic rather than extrinsic apoptosis signaling . Positive_regulation CASP5 TNFSF10 17804742 1791211 Although the proteolytic processing of procaspase-3 by TRAIL was partially blocked in glioma cells , cotreatment with silibinin efficiently recovered *induced* [caspase] activation in these cells . Positive_regulation CASP5 TNFSF10 18483385 1910830 Aspirin sensitized human breast cancer cells , but not untransformed human mammary epithelial cells , to induced [caspase] *activation* and apoptosis by a cyclooxygenase-2 independent mechanism . Positive_regulation CASP5 TNFSF10 18665234 1943062 Stable knockdown of bid lead to a pronounced resistance to Fas/CD95- and *induced* [caspase] activation and apoptosis , and significantly increased clonogenic survival . Positive_regulation CASP5 TNFSF10 18980244 1995225 While the proteolytic processing of procaspase-3 by TRAIL was partially blocked in various HCC cells treated with TRAIL alone , co-treatment with quercetin efficiently recovered *induced* [caspase] activation . Positive_regulation CASP5 TNFSF10 20400979 2274063 The ability of ovarian cancer ascites to activate Akt and inhibit *induced* cell death and [caspase] activity was decreased by heat inactivation , but was retained in ascites fractions > 5 kDa . Positive_regulation CASP5 TNFSF10 20400979 2274076 These results suggest that ovarian cancer ascites induces FAK and Akt activation in an alphavbeta5 integrin dependent pathway , which confers protection from induced cell death and [caspase] *activation* . Positive_regulation CASP5 TNFSF10 21109947 2366199 induced [caspase/p38] *activation* is responsible for the increased catalytic and invasive activities of Akt . Positive_regulation CASP5 TNFSF10 22991197 2734932 We demonstrate that EGFR targeted in combination with BZB *induced* significantly higher [caspase] activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation CASP5 TNFSF10 23180246 2723792 *induces* autophagic protein cleavage through [caspase] activation in melanoma cell lines under arginine deprivation . Positive_regulation CASP5 TNFSF10 24525736 2914812 Treatment of hepatoma cells with salubrinal , an inhibitor of eIF2a dephosphorylation , enhances *induced* eIF2a phosphorylation , CCAAT/enhancer binding protein homologous protein ( CHOP ) expression and [caspase] activation . Positive_regulation CASP5 TNFSF10 24525736 2914826 Moreover , knockdown of growth arrest and DNA damage-inducible protein 34 ( GADD34 ) , which recruits protein phosphatase 1 to dephosphorylate eIF2a , enhances induced eIF2a phosphorylation , CHOP expression , [caspase] *activation* and apoptosis . Positive_regulation CASP5 TNFSF10 24525736 2914840 Knockdown of CHOP abrogates the stimulation of *induced* [caspase] activation and apoptosis by salubrinal . Positive_regulation CASP6 CAPN8 11449356 836255 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Positive_regulation CASP6 CAPN8 12358768 994393 Calpain inhibitor III ( MDL-28170 ) reduced caspase activation , suggesting that [caspase] activation was *mediated* by . Positive_regulation CASP6 CAPN8 12917442 1151091 Interestingly , the overexpression of parkin induced the activation of an intracellular cysteine protease , calpain , but not [caspase] , and the cytoprotective effect of parkin on alpha-synuclein cytotoxicity was significantly *inhibited* by the presence of inhibitors . Positive_regulation CASP6 CAPN8 16597613 1604288 However , PD-150606 also attenuated caspase-3 activity and apoptosis at 24 h , suggesting *dependent* [caspase] activation . Positive_regulation CASP6 CCND1 12480939 1078954 Bcl-2 controls [caspase] activation *following* a p53 dependent death signal . Positive_regulation CASP6 EPHB2 15304372 1322272 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Positive_regulation CASP6 EPHB2 16397410 1512974 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP6 EPHB2 17192846 1701821 These effects were paralleled by disruption of Ras -- > and Akt survival pathways , consequent decreased phosphorylation of both mitochondrial bcl-2 and bad proteins , and [caspase] *activation* . Positive_regulation CASP6 EPHB2 19709398 2139140 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Positive_regulation CASP6 EPHB2 20177944 2236713 This [caspase] activation is *mediated* by phosphorylation of Akt and . Positive_regulation CASP6 EPHB2 21364665 2361124 dependent multiple [caspase] *activation* by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP6 EPHB2 22193398 2543484 Overexpression of ZnT-1 markedly reduced LDH release and caspase activation following I/R. Knockdown of endogenous ZnT-1 augmented the I/R induced release of LDH and increased [caspase] *activation* following I/R. levels were significantly increased following I/R in cells overexpressing ZnT-1 , while knockdown of ZnT-1 reduced phospho-ERK levels . Positive_regulation CASP6 EPHB2 22554503 2590596 The activation of increased XIAP expression and *led* to decreased [caspase] activation . Positive_regulation CASP6 FAS 10213689 608076 *induced* [caspase] denitrosylation . Positive_regulation CASP6 FAS 10352269 617209 In strict contrast , TPA is an ineffective inhibitor when cell death is induced by the potassium ionophore valinomycin , the specific mitochondrial benzodiazepine ligand PK11195 , or by primary [caspase] *activation* by cross linking . Positive_regulation CASP6 FAS 10364198 620469 EGF stimulation of epithelial cells also inhibited *induced* [caspase] activation and the proteolysis of signaling proteins downstream of the EGF receptor , Cbl and Akt/protein kinase B ( Akt ) . Positive_regulation CASP6 FAS 10391681 626718 ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , [caspase] activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation CASP6 FAS 10391681 626734 M3/6 prevented Fas stimulation of JNK , but did not affect mediated [caspase] *activation* or cell death , demonstrating that JNK activation is not required for these processes . Positive_regulation CASP6 FAS 10405325 629345 induced [caspase] *activation* and nuclear apoptosis , however , were unaffected by the depletion of ATP . Positive_regulation CASP6 FAS 10464143 640282 Suppression of *induced* activation of the [caspase] by IL-1beta was diminished by coadministration with D-galactosamine and reversed by coinjection with an excess amount of uridine . Positive_regulation CASP6 FAS 10545115 564284 Taken together , these findings argue that hDaxx promotes sensitivity to Fas from a nuclear location , probably by modulating the transcription of genes involved in *induced* [caspase] activation and apoptosis . Positive_regulation CASP6 FAS 10706558 673183 In conclusion , in vivo stimulation *causes* [caspase] activation , mitochondrial permeability transition ( decreasing the membrane potential and increasing basal respiration ) , mitochondrial matrix expansion ( as shown by matrix herniation ) , outer mitochondrial membrane rupture , and cytochrome c release . Positive_regulation CASP6 FAS 10749152 681133 These results indicate that mediated [caspase] *activation* elicits two independent cellular responses ; Positive_regulation CASP6 FAS 10766189 684364 The caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp ( OMe ) fluoromethyl ketone ( zVADfmk ) , at concentrations that completely prevent apoptosis and [caspase] activation *induced* by ligation of the death receptor , had only a partial protective effect on onconase induced cell death . Positive_regulation CASP6 FAS 11260077 796094 ligation increased apoptosis and decreased colony growth equally in RARS and controls , but *caused* significantly more [caspase] activation in RARS ( P < 0.01 ) . Positive_regulation CASP6 FAS 11278283 819068 Staurosporine activates MST either caspase-dependently or independently , whereas ligation *activates* it only [caspase-dependently] . Positive_regulation CASP6 FAS 11295536 801388 NH ( 2 ) Cl pretreatment significantly inhibited apoptosis and [caspase] activation *induced* by etoposide or camptothecin , a DNA topoisomerase I poison , but not by staurosporine or stimulation . Positive_regulation CASP6 FAS 11322649 807150 Gamma-interferon ( IFN-gamma ) augments apoptotic response to mistletoe lectin-II via upregulation of L expression and [caspase] *activation* in human myeloid U937 cells . Positive_regulation CASP6 FAS 11359796 816303 In isolated GC B cells , cFLIP ( L ) decays rapidly even without ligation , and this *results* in activation of [caspase] activity and apoptosis . Positive_regulation CASP6 FAS 11368434 817079 *induced* [caspase] activity is increased in RARS bone marrow cells . Positive_regulation CASP6 FAS 11536010 854848 We conclude that ( i ) synergistic induction of apoptosis by C2-ceramide and CD95L depend on a cross-talk between the two signal transduction pathways and that ( ii ) C2-ceramide , independently of its sensitizing effects on *dependent* [caspase] activation , is also capable of triggering an apoptotic signaling cascade that is unaffected by zVAD-fmk mediated caspase inhibition , but promoted by high levels of CD95 expression . Positive_regulation CASP6 FAS 11551934 882153 PI3-kinase inhibition sensitized to apoptosis by increasing and accelerating mediated [caspase] *activation* . Positive_regulation CASP6 FAS 11673515 872828 Thus , *induced* initiation of [caspase] activity at the plasma membrane may in some cells result in local proteolysis of submembrane proteins , leading to generation of membrane vesicles that are highly enriched in active caspase 8 . Positive_regulation CASP6 FAS 11698497 878164 Interleukin (IL)-5 and interferon (IFN)-gamma , two cytokines known to prolong eosinophil survival , inhibited mediated apoptosis and [caspase] *activation* but poorly affected the decrease in DeltaPsi ( m ) . Positive_regulation CASP6 FAS 11699200 878334 Recent work has demonstrated that the degree of spontaneous caspase activation in FHL lymphocytes is attenuated in vitro whereas mediated [caspase] *activation* and apoptosis induction remains unmitigated , and FHL can thus be distinguished from the related chronic disorder of immune regulation termed autoimmune lymphoproliferative syndrome or ALPS . Positive_regulation CASP6 FAS 11834943 911168 Lamivudine was also found to stimulate in vitro *induced* apoptosis and [caspase] activation in pre activated T lymphocytes from healthy donors . Positive_regulation CASP6 FAS 12165276 972787 Further investigation of *mediated* [caspase] activities revealed that supplementation of glutamine significantly decreased caspase-3 and caspase-8 activities in activated T cells . Positive_regulation CASP6 FAS 12207331 983594 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Positive_regulation CASP6 FAS 12221075 998196 Enforced expression of GPx1 also resulted in inhibition of induced effector [caspase] *activation* , DNA fragmentation , and apoptotic cell death . Positive_regulation CASP6 FAS 12393561 1035693 Moreover , we have previously reported that G-CSF inhibits induced [caspase] *activation* in sideroblastic anemia ( RARS ) . Positive_regulation CASP6 FAS 12393594 1031526 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Positive_regulation CASP6 FAS 12404126 1009728 Structure-function analysis determined that ATP hydrolysis was necessary for P-gp to confer resistance to induced [caspase] *activation* and cell death . Positive_regulation CASP6 FAS 12444127 1017312 These data indicate that TCR ligation can activate nonapoptotic death programs in WT CD8 ( + ) and CD8 ( + ) T blasts that normally are masked by mediated [caspase] *activation* . Positive_regulation CASP6 FAS 12605597 1079485 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block and etoposide *induced* [caspase] activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation CASP6 FAS 12700647 1082034 Myriocin did not modulate the expression of CD95 or CD95L , instead , it interfered with the early steps of mediated [caspase] *activation* . Positive_regulation CASP6 FAS 12760867 1091402 This effect was correlated with an increase in mediated [caspase] *activation* and enhanced cleavage of the caspase substrate poly ( ADP-ribose ) polymerase . Positive_regulation CASP6 FAS 12760867 1091415 Furthermore , the positive effect on mediated [caspase] *activation* by IFN and ribavirin was confirmed by immunocytochemistry for activated caspase-3 and by immunoblot detection of activated caspase-3 , caspase-7 , and caspase-8 . Positive_regulation CASP6 FAS 12760867 1091428 IFN and ribavirin also enhance mediated [caspase] *activation* , which might in part be responsible for the apoptosis promoting effect of these antiviral compounds . Positive_regulation CASP6 FAS 12850790 1109576 Here , newly developed suicide genes , including *inducible* , inducible [caspase] and CD20 are discussed . Positive_regulation CASP6 FAS 12855571 1149823 Importantly , up-regulation of Gadd45 beta by CD40 precedes *induced* [caspase] activation , as well as up-regulation of other NF-kappa B-controlled inhibitors of apoptosis such as Bcl-xL and c-FLIPL . Positive_regulation CASP6 FAS 12938225 1133114 Co-incubation with cycloheximide partially reversed protection from apoptosis and increased *stimulated* initiator and effector [caspase] activation , suggesting new protein synthesis is necessary to induce protection upstream of caspase activation . Positive_regulation CASP6 FAS 14576776 1156542 The spontaneous death of CD4+ and CD8+ T cells was not prevented by a decoy CD95 receptor or by a broad-spectrum caspase inhibitor ( zVAD-fmk ) , suggesting that this form of cell death is independent of interaction and [caspase] *activation* . Positive_regulation CASP6 FAS 14675162 1189364 Both and anti-CD95 antibodies *triggered* [caspase] activation followed by apoptotic death in fully pro-inflammatory astrocytes , whereas resting cells were totally resistant . Positive_regulation CASP6 FAS 14690854 1194682 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , , and TRAIL receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP6 FAS 15197350 1347077 The inhibitory activity of TPCK was found to be death ligand-specific since TPCK inhibits TRAIL mediated caspase activity but does not affect *induced* [caspase] activity . Positive_regulation CASP6 FAS 15322156 1286765 Consistent with its role in cell death induction , deletion of caspase-8 in hepatocytes protected them from *induced* [caspase] activation and death . Positive_regulation CASP6 FAS 15648737 1350021 These findings suggest that mild hypothermia suppresses *mediated* apoptosis of liver cells by the partial inhibition of signaling events including mitochondrial damage , cytochrome c release , and subsequent apoptosome formation and effector [caspase] activation . Positive_regulation CASP6 FAS 15863130 1401085 Binding of Fas ligand or agonistic anti-Fas antibody to the death receptor can *activate* a [caspase-cascade] resulting in apoptosis . Positive_regulation CASP6 FAS 16120269 895977 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Positive_regulation CASP6 FAS 16384930 1547177 JAK2 mutated PV erythroblasts showed lower levels of induced [caspase] *activation* and incomplete caspase mediated cleavage of the erythroid transcription factor GATA-1 , which was entirely degraded in normal erythroblasts on CD95 stimulation . Positive_regulation CASP6 FAS 16527894 1574407 Simultaneously , mediated [caspase] *activation* precipitates differentiation . Positive_regulation CASP6 FAS 16646028 1557204 stimulation activated NF-kappaB and AP-1 , and this response *required* [caspase] activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation CASP6 FAS 17245429 1690842 The nucleo-cytoplasmic translocation of FLASH requires *induced* [caspase] activation and is facilitated by the Crm1 dependent nuclear export pathway . Positive_regulation CASP6 FAS 17304508 1718981 These results suggest the possible involvement of multiple signaling pathways from the MAPK to the subsequent mitochondria- and/or mediated [caspase] *activation* are potential requirements for PCA induced AGS apoptosis . Positive_regulation CASP6 FAS 18386902 1907142 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , [caspase] activation , and *induction* . Positive_regulation CASP6 FAS 18593565 1953610 induced [caspase] *activation* leads to degradation of gp130 , thereby suppressing IL-6 induced phosphorylation of STAT3 ( Tyr ( 705 ) ) and of tyrosine phosphatase SHP2 ( Tyr ( 580 ) ) . Positive_regulation CASP6 FAS 18948840 2041288 All *led* to a reduced DISC formation and diminished initiator [caspase] activity upon CD95-stimulation , whereas a marked heterogeneity in sensitivity to CD95 induced killing was found . Positive_regulation CASP6 FAS 19002587 1991271 In epithelial cells , *induced* hierarchic [caspase] activation is also linked with DEDD , a member of the DED family that binds to keratin (K) intermediate filaments ( IFs ) . Positive_regulation CASP6 FAS 19111607 2031767 However , recent studies have shown that can *induce* nonapoptotic [caspase independent cell death (CICD)] when caspase activity is inhibited . Positive_regulation CASP6 FAS 19680267 2157906 CD95 is a death receptor whose stimulation by either the physiologic ligand or the agonistic antibodies *leads* to the formation of a multi-molecular complex termed DISC ( death inducing signaling complex ) and the subsequent induction of a [caspase-driven] apoptotic signal . Positive_regulation CASP6 FAS 20876774 2368752 Simultaneous downregulation of c-FLIP ( L ) and c-FLIP ( S ) as well as individual knockdown of either isoform by RNA interference significantly enhances TRAIL ( tumour necrosis factor related apoptosis inducing ligand ) - and *induced* [caspase] activation and caspase dependent apoptosis . Positive_regulation CASP6 FAS 22543586 2750631 Furthermore , loss of RAGE increased expression of the death receptor CD95 ( Fas , Apo-1 ) , dependent [caspase] *activation* and extrinsic apoptosis , whereas NF-kB-p65 nuclear translocation was diminished . Positive_regulation CASP6 FAS 23029562 2681061 Blocking the ERK pathway using a pharmacological inhibitor increased the susceptibility of 661W cells to induced [caspase] *activation* and apoptosis . Positive_regulation CASP6 FAS 23530784 2762302 Various methods to inhibit apoptosis including the cell surface receptor pathway inhibitors , [caspase] *inhibitors* , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation CASP6 FAS 24928990 2946823 Real-time detection of CTL function reveals distinct patterns of [caspase] activation *mediated* by versus granzyme B . Positive_regulation CASP6 FAS 24928990 2946851 Thus , we have used a novel , real-time assay to demonstrate the distinct pattern of [caspase] activation *induced* by granzyme B versus in human and murine CTLs . Positive_regulation CASP6 FAS 9637489 513685 Here , we investigated whether the apoptosis occurring after TCR/CD9 stimulation is associated with a death pathway involving Fas stimulation and mediated [caspase] *activation* as observed in activation induced cell death ( AICD ) . Positive_regulation CASP6 FAS 9694885 524302 Our results demonstrate that whereas mediated activation of caspase 3 *requires* an upstream [caspase] activity that is zVAD-fmk-sensitive , the initial cleavage of caspase 3 during granule mediated cell death is insensitive to zVAD-fmk , suggesting that caspase 3 is cleaved directly by granzyme B in vivo . Positive_regulation CASP6 IL1B 15201138 1288920 N ( G ) -monomethyl-l-arginine , a known inhibitor of inducible nitric oxide synthetase (iNOS) , markedly inhibited *induced* iNOS gene expression , NO release , caspase-3 and [caspase-6] activation , lamin B degradation , and loss of metabolic cell viability , indicating that the observed IL-1beta induced effects on nuclear lamin B involve the intermediacy of NO . Positive_regulation CASP6 IL1B 16305880 1485875 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , and interleukin-6 , and *activation* of caspase-1 , caspase-3 and [caspase-11] . Positive_regulation CASP6 MAOA 17883400 1830024 Two unrelated inhibitors *reduced* [caspase] activation . Positive_regulation CASP6 MAP2K6 16397410 1512980 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP6 MAP2K6 16672322 1583745 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* [caspase] activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only caspase activity . Positive_regulation CASP6 MAP2K6 21364665 2361130 dependent multiple [caspase] *activation* by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP6 MMP28 13679861 1140591 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP6 MMP7 13679861 1140606 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP6 RNASE1 15620724 1357826 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and induced [caspase] *activation* in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP6 RNASE1 15620724 1358060 We find that and RC-RNase/IFN-gamma *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP6 RNASE7 15620724 1357834 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and induced [caspase] *activation* in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP6 RNASE7 15620724 1358068 We find that and RC-RNase/IFN-gamma *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP6 SPHK1 11238741 791088 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Positive_regulation CASP6 TNF 10425195 632760 *induces* [caspase] activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation CASP6 TNF 10586080 571805 Silymarin also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated induced cytotoxicity and [caspase] *activation* . Positive_regulation CASP6 TNF 10593992 572963 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Positive_regulation CASP6 TNF 10764744 698798 Addition of H ( 2 ) O ( 2 ) prevented induced apoptosis and [caspase] *activation* , an effect prevented by simultaneous addition of catalase . Positive_regulation CASP6 TNF 10820260 694392 *induced* cytotoxicity , [caspase] activation , and lipid peroxidation were also abolished by vesnarinone . Positive_regulation CASP6 TNF 10843709 700178 Resveratrol also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated induced cytotoxicity and [caspase] *activation* . Positive_regulation CASP6 TNF 11228746 581009 induced *activation* of [caspase] activity was blocked by all three types of quenchers . Positive_regulation CASP6 TNF 11847111 912597 mediated [caspase] *activation* and block of differentiation are dependent upon the expression of PW1 , but occur independently of NFkappaB activation . Positive_regulation CASP6 TNF 12036088 949070 *promotes* [caspase] activation and apoptosis in human fetal membranes . Positive_regulation CASP6 TNF 12080044 976121 We also showed that stable overexpression of A20 inhibits apoptosis and [caspase] activation *induced* by . Positive_regulation CASP6 TNF 12431778 1015387 Our results demonstrate that TGF-beta1 can decrease TNF-alpha induced apoptosis in murine osteoblasts at least in part by attenuating *induced* [caspase] gene expression . Positive_regulation CASP6 TNF 12663669 1092652 In the presence of cycloheximide , or interleukin-1 *initiates* [caspase] activation , loss of mitochondrial membrane potential ( DeltaPsi ) , DNA degradation , and nuclear condensation and fragmentation characteristic of apoptotic cell death in human vascular endothelial cells ( EC ) . Positive_regulation CASP6 TNF 12763364 1093894 The latter and mediated [caspase] *activation* was attenuated by prostaglandin E ( 2 ) . Positive_regulation CASP6 TNF 12800192 1098918 The antioxidants N-acetylcysteine , reduced glutathione , lipoic acid and ascorbic acid markedly reduced the enhancing effect of the hormone on induced [caspase] *activation* . Positive_regulation CASP6 TNF 12800192 1098931 The effect of calcitriol on DeltaPsi was mimicked by rotenone , which increased both the drop in DeltaPsi and [caspase] activation *induced* by . Positive_regulation CASP6 TNF 12815280 1103446 Here we show that zDRHDfmk inhibits *induced* [caspase 6] activity and apoptosis in breast cancer cells . Positive_regulation CASP6 TNF 15033766 1184112 The antioxidants N-acetylcysteine , glutathione , lipoic acid , and ascorbic acid markedly reduced the effect of the hormone on induced [caspase] *activation* , attesting to the involvement of reactive oxygen species ( ROS ) in the cross-talk between the hormone and the cytokine . Positive_regulation CASP6 TNF 15283855 1277825 In the *presence* of or endotoxin ( LPS ) , blockade of CD18 ( beta2 chain ) with mAb markedly increased [caspase] activation in PMN on fibrinogen . Positive_regulation CASP6 TNF 15452110 1341977 These mutant cells exhibited a defect in *induced* [caspase] activation , Bid cleavage , and release of cytochrome c . Positive_regulation CASP6 TNF 16532377 1555288 Inhibition of the p38 and/or the JNK death pathways reduced [caspase] activation *induced* by oxidative stress , hyperosmotic shock and . Positive_regulation CASP6 TNF 16631528 1552354 We report that DDC strongly inhibits [caspase] activation , loss of DeltaPsim , and cell death *induced* by or etoposide . Positive_regulation CASP6 TNF 17047073 1635892 Importantly , down-regulation of TRAIL by small interfering RNA silencing decreased mediated Adriamycin induced [caspase] *activation* and apoptosis , and thus enhanced breast cancer cell resistance to Adriamycin . Positive_regulation CASP6 TNF 17125837 1686483 ATD5 could also reduce the TNF-alpha mediated cytotoxicity and inhibit mediated [caspase] *activation* on L929 cells in a dose dependent manner . Positive_regulation CASP6 TNF 17599041 1848497 We have recently shown that *induces* [caspase dependent and -independent] JNK activation and ROS accumulation in cellular FLICE-inhibitory protein ( c-Flip ) ( -/- ) murine embryonic fibroblasts ( MEFs ) . Positive_regulation CASP6 TNF 18023359 1832134 Mitochondrial apoptotic inducer bax , and the suppressor bcl-2 were evaluated using western blotting at 48 h. Results indicated that *increased* [caspase] activities and resulted in a significant ( p = 0.001 ) increase in bax/bcl-2 ratio . Positive_regulation CASP6 TNF 18467439 1938881 However , XIAP small interfering RNA restored *induced* [caspase] signaling and apoptosis in Hec-1A cells ; Positive_regulation CASP6 TNF 19345705 2094386 Finally , reconstitution of PPT1 activity in mutant cells was accompanied by resensitization to induced [caspase] *activation* and toxicity . Positive_regulation CASP6 TNF 19440308 2078412 Muscle regeneration is , at least in part , regulated by caspase activation , and AVP abrogated *dependent* [caspase] activation . Positive_regulation CASP6 TNF 20200974 2299815 Silencing FOXO1 using siRNA in vitro significantly reduced *induced* apoptosis and [caspase] activity in differentiated chondrocytes . Positive_regulation CASP6 TNF 21269505 2392749 is also *required* for appropriate regulation of [caspase] genes . Positive_regulation CASP6 TNF 21893119 2506482 Conversely , *activation* of [caspase] by exogenous required IL-13 , TWEAK , and Fn14 . Positive_regulation CASP6 TNF 24531553 2918965 Recombinant [CASP6] ( rCASP6 ) *induced* marked release in microglial cultures , and most microglia within the spinal cord expressed Tnfa . Positive_regulation CASP6 TNF 24684347 2935144 Smac-mimetic 1-induced loss of cIAPs correlated with inhibition of mediated NF-?B activation , [caspase] *activation* , and tumor cell killing . Positive_regulation CASP6 TNF 9531309 496830 Furthermore , only murine but not IL-1alphabeta *increased* [caspase] activity and apoptosis . Positive_regulation CASP6 TNF 9885230 584458 induced [caspase] *activation* was accompanied by a decrease in the ability of neutrophils to release superoxide anion . Positive_regulation CASP6 TNF 9885230 584484 Granulocyte-macrophage colony stimulating factor inhibited induced [caspase] *activation* and apoptosis , while reversing the diminution in superoxide release . Positive_regulation CASP6 TNFSF10 11677236 896124 Combining and interferon in vitro , synergistically *induced* apoptosis and [caspase] activation in breast cancer cells . Positive_regulation CASP6 TNFSF10 12815069 1103420 In addition , overexpression of cleavage-site mutant c-IAP1 makes cells more resistant to induced [caspase] *activation* . Positive_regulation CASP6 TNFSF10 14644092 1188260 Furthermore , the enhancement extended to *induced* [caspase-activation] . Positive_regulation CASP6 TNFSF10 14690854 1194683 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , Fas , and receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP6 TNFSF10 15197350 1347064 In this study , we show that TPCK inhibits *induced* [caspase] activity but potentiates wortmannin dependent caspase activity in prostatic carcinoma cell lines . Positive_regulation CASP6 TNFSF10 15558024 1361131 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both promoted by amiloride . Positive_regulation CASP6 TNFSF10 15569667 1368291 Here we demonstrate that human breast cancer cells , but not normal mammary epithelial cells , are dramatically sensitized to induced apoptosis and [caspase] *activation* by peroxisome proliferator activated receptor gamma ( PPARgamma ) agonists of the thiazolidinedione ( TZD ) class . Positive_regulation CASP6 TNFSF10 16103097 1444526 Generation of ROS by CCCP was responsible for *induced* Bax and [caspase] activation because scavenging ROS completely abrogated apical caspase-8 activation and further downstream events leading to cell death . Positive_regulation CASP6 TNFSF10 17031854 1700280 Here we demonstrated that human prostate cancer cells , but not normal prostate cells , are dramatically sensitized to induced apoptosis and [caspase] *activation* by quercetin . Positive_regulation CASP6 TNFSF10 17031854 1700293 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both enhanced by quercetin . Positive_regulation CASP6 TNFSF10 17545549 1751979 We isolated primary tumor cells from 13 astrocytoma and oligoastrocytoma patients of all four WHO grades of malignancy and compared the levels of *induced* apoptosis induction , long-term tumor cell survival , [caspase] , and caspase target cleavage . Positive_regulation CASP6 TNFSF10 17724141 1822425 Rituximab , a CD20 antibody used to treat certain types of NHL , augmented *induced* [caspase] activation in Ramos RA1 and DoHH2 but not BJAB or SC-1 cells , through modulation of intrinsic rather than extrinsic apoptosis signaling . Positive_regulation CASP6 TNFSF10 17804742 1791212 Although the proteolytic processing of procaspase-3 by TRAIL was partially blocked in glioma cells , cotreatment with silibinin efficiently recovered induced [caspase] *activation* in these cells . Positive_regulation CASP6 TNFSF10 18483385 1910831 Aspirin sensitized human breast cancer cells , but not untransformed human mammary epithelial cells , to induced [caspase] *activation* and apoptosis by a cyclooxygenase-2 independent mechanism . Positive_regulation CASP6 TNFSF10 18665234 1943063 Stable knockdown of bid lead to a pronounced resistance to Fas/CD95- and *induced* [caspase] activation and apoptosis , and significantly increased clonogenic survival . Positive_regulation CASP6 TNFSF10 18980244 1995226 While the proteolytic processing of procaspase-3 by TRAIL was partially blocked in various HCC cells treated with TRAIL alone , co-treatment with quercetin efficiently recovered induced [caspase] *activation* . Positive_regulation CASP6 TNFSF10 20400979 2274064 The ability of ovarian cancer ascites to activate Akt and inhibit *induced* cell death and [caspase] activity was decreased by heat inactivation , but was retained in ascites fractions > 5 kDa . Positive_regulation CASP6 TNFSF10 20400979 2274077 These results suggest that ovarian cancer ascites induces FAK and Akt activation in an alphavbeta5 integrin dependent pathway , which confers protection from *induced* cell death and [caspase] activation . Positive_regulation CASP6 TNFSF10 21109947 2366200 *induced* [caspase/p38] activation is responsible for the increased catalytic and invasive activities of Akt . Positive_regulation CASP6 TNFSF10 22991197 2734933 We demonstrate that EGFR targeted in combination with BZB *induced* significantly higher [caspase] activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation CASP6 TNFSF10 23180246 2723793 *induces* autophagic protein cleavage through [caspase] activation in melanoma cell lines under arginine deprivation . Positive_regulation CASP6 TNFSF10 24525736 2914813 Treatment of hepatoma cells with salubrinal , an inhibitor of eIF2a dephosphorylation , enhances induced eIF2a phosphorylation , CCAAT/enhancer binding protein homologous protein ( CHOP ) expression and [caspase] *activation* . Positive_regulation CASP6 TNFSF10 24525736 2914827 Moreover , knockdown of growth arrest and DNA damage-inducible protein 34 ( GADD34 ) , which recruits protein phosphatase 1 to dephosphorylate eIF2a , enhances *induced* eIF2a phosphorylation , CHOP expression , [caspase] activation and apoptosis . Positive_regulation CASP6 TNFSF10 24525736 2914841 Knockdown of CHOP abrogates the stimulation of induced [caspase] *activation* and apoptosis by salubrinal . Positive_regulation CASP7 CAPN8 10487751 645005 We demonstrate that specifically *triggers* activation and processing of [caspase-7] both in vitro and in vivo , and that both processes are inhibited by calpain inhibitors . Positive_regulation CASP7 CAPN8 11449356 836269 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Positive_regulation CASP7 CAPN8 12358768 994408 Calpain inhibitor III ( MDL-28170 ) reduced caspase activation , suggesting that [caspase] activation was *mediated* by . Positive_regulation CASP7 CAPN8 12917442 1151105 Interestingly , the overexpression of parkin induced the activation of an intracellular cysteine protease , calpain , but not [caspase] , and the cytoprotective effect of parkin on alpha-synuclein cytotoxicity was significantly *inhibited* by the presence of inhibitors . Positive_regulation CASP7 CAPN8 16597613 1604302 However , PD-150606 also attenuated caspase-3 activity and apoptosis at 24 h , suggesting *dependent* [caspase] activation . Positive_regulation CASP7 CAPN8 18842681 2028551 CDDP- and adriamycin induced activation of [caspase-4 and -7] appeared to be *mediated* by activity in that it was blocked by the calpain inhibitors calpeptin and PD150606 even when GRP78 was inhibited by siRNA . Positive_regulation CASP7 CAPN8 19617626 2131171 Our studies suggest the *activated* form of [caspase-7] has unique enzymatic activity , localization , and binding affinity when compared with the caspase activated form . Positive_regulation CASP7 CCND1 12480939 1078956 Bcl-2 controls [caspase] activation *following* a p53 dependent death signal . Positive_regulation CASP7 EPHB2 15304372 1322273 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Positive_regulation CASP7 EPHB2 16397410 1512982 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP7 EPHB2 17192846 1701822 These effects were paralleled by disruption of Ras -- > and Akt survival pathways , consequent decreased phosphorylation of both mitochondrial bcl-2 and bad proteins , and [caspase] *activation* . Positive_regulation CASP7 EPHB2 19709398 2139142 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Positive_regulation CASP7 EPHB2 20177944 2236717 This [caspase] activation is *mediated* by phosphorylation of Akt and . Positive_regulation CASP7 EPHB2 21364665 2361132 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP7 EPHB2 22193398 2543487 Overexpression of ZnT-1 markedly reduced LDH release and caspase activation following I/R. Knockdown of endogenous ZnT-1 augmented the I/R induced release of LDH and increased [caspase] *activation* following I/R. levels were significantly increased following I/R in cells overexpressing ZnT-1 , while knockdown of ZnT-1 reduced phospho-ERK levels . Positive_regulation CASP7 EPHB2 22554503 2590597 The activation of increased XIAP expression and *led* to decreased [caspase] activation . Positive_regulation CASP7 F3 21472232 2361557 VIIa *regulates* interleukin-8 , tissue factor and [caspase-7] expression in SW620 cells through protease activated receptor-2 activation . Positive_regulation CASP7 FAS 10213689 608077 *induced* [caspase] denitrosylation . Positive_regulation CASP7 FAS 10352269 617210 In strict contrast , TPA is an ineffective inhibitor when cell death is induced by the potassium ionophore valinomycin , the specific mitochondrial benzodiazepine ligand PK11195 , or by primary [caspase] *activation* by cross linking . Positive_regulation CASP7 FAS 10364198 620470 EGF stimulation of epithelial cells also inhibited *induced* [caspase] activation and the proteolysis of signaling proteins downstream of the EGF receptor , Cbl and Akt/protein kinase B ( Akt ) . Positive_regulation CASP7 FAS 10391681 626719 ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , [caspase] activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation CASP7 FAS 10391681 626735 M3/6 prevented Fas stimulation of JNK , but did not affect mediated [caspase] *activation* or cell death , demonstrating that JNK activation is not required for these processes . Positive_regulation CASP7 FAS 10405325 629346 *induced* [caspase] activation and nuclear apoptosis , however , were unaffected by the depletion of ATP . Positive_regulation CASP7 FAS 10464143 640283 Suppression of induced *activation* of the [caspase] by IL-1beta was diminished by coadministration with D-galactosamine and reversed by coinjection with an excess amount of uridine . Positive_regulation CASP7 FAS 10545115 564285 Taken together , these findings argue that hDaxx promotes sensitivity to Fas from a nuclear location , probably by modulating the transcription of genes involved in induced [caspase] *activation* and apoptosis . Positive_regulation CASP7 FAS 10706558 673184 In conclusion , in vivo stimulation *causes* [caspase] activation , mitochondrial permeability transition ( decreasing the membrane potential and increasing basal respiration ) , mitochondrial matrix expansion ( as shown by matrix herniation ) , outer mitochondrial membrane rupture , and cytochrome c release . Positive_regulation CASP7 FAS 10749152 681134 These results indicate that mediated [caspase] *activation* elicits two independent cellular responses ; Positive_regulation CASP7 FAS 10766189 684365 The caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp ( OMe ) fluoromethyl ketone ( zVADfmk ) , at concentrations that completely prevent apoptosis and [caspase] activation *induced* by ligation of the death receptor , had only a partial protective effect on onconase induced cell death . Positive_regulation CASP7 FAS 11260077 796095 ligation increased apoptosis and decreased colony growth equally in RARS and controls , but *caused* significantly more [caspase] activation in RARS ( P < 0.01 ) . Positive_regulation CASP7 FAS 11278283 819069 Staurosporine activates MST either caspase-dependently or independently , whereas ligation *activates* it only [caspase-dependently] . Positive_regulation CASP7 FAS 11295536 801389 NH ( 2 ) Cl pretreatment significantly inhibited apoptosis and [caspase] activation *induced* by etoposide or camptothecin , a DNA topoisomerase I poison , but not by staurosporine or stimulation . Positive_regulation CASP7 FAS 11322649 807152 Gamma-interferon ( IFN-gamma ) augments apoptotic response to mistletoe lectin-II via upregulation of L expression and [caspase] *activation* in human myeloid U937 cells . Positive_regulation CASP7 FAS 11359796 816304 In isolated GC B cells , cFLIP ( L ) decays rapidly even without ligation , and this *results* in activation of [caspase] activity and apoptosis . Positive_regulation CASP7 FAS 11368434 817080 *induced* [caspase] activity is increased in RARS bone marrow cells . Positive_regulation CASP7 FAS 11536010 854849 We conclude that ( i ) synergistic induction of apoptosis by C2-ceramide and CD95L depend on a cross-talk between the two signal transduction pathways and that ( ii ) C2-ceramide , independently of its sensitizing effects on dependent [caspase] *activation* , is also capable of triggering an apoptotic signaling cascade that is unaffected by zVAD-fmk mediated caspase inhibition , but promoted by high levels of CD95 expression . Positive_regulation CASP7 FAS 11551934 882154 PI3-kinase inhibition sensitized to apoptosis by increasing and accelerating mediated [caspase] *activation* . Positive_regulation CASP7 FAS 11673515 872829 Thus , *induced* initiation of [caspase] activity at the plasma membrane may in some cells result in local proteolysis of submembrane proteins , leading to generation of membrane vesicles that are highly enriched in active caspase 8 . Positive_regulation CASP7 FAS 11698497 878165 Interleukin (IL)-5 and interferon (IFN)-gamma , two cytokines known to prolong eosinophil survival , inhibited *mediated* apoptosis and [caspase] activation but poorly affected the decrease in DeltaPsi ( m ) . Positive_regulation CASP7 FAS 11699200 878335 Recent work has demonstrated that the degree of spontaneous caspase activation in FHL lymphocytes is attenuated in vitro whereas mediated [caspase] *activation* and apoptosis induction remains unmitigated , and FHL can thus be distinguished from the related chronic disorder of immune regulation termed autoimmune lymphoproliferative syndrome or ALPS . Positive_regulation CASP7 FAS 11834943 911169 Lamivudine was also found to stimulate in vitro induced apoptosis and [caspase] *activation* in pre activated T lymphocytes from healthy donors . Positive_regulation CASP7 FAS 12165276 972788 Further investigation of *mediated* [caspase] activities revealed that supplementation of glutamine significantly decreased caspase-3 and caspase-8 activities in activated T cells . Positive_regulation CASP7 FAS 12207331 983595 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Positive_regulation CASP7 FAS 12221075 998198 Enforced expression of GPx1 also resulted in inhibition of induced effector [caspase] *activation* , DNA fragmentation , and apoptotic cell death . Positive_regulation CASP7 FAS 12393561 1035694 Moreover , we have previously reported that G-CSF inhibits *induced* [caspase] activation in sideroblastic anemia ( RARS ) . Positive_regulation CASP7 FAS 12393594 1031527 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Positive_regulation CASP7 FAS 12404126 1009729 Structure-function analysis determined that ATP hydrolysis was necessary for P-gp to confer resistance to *induced* [caspase] activation and cell death . Positive_regulation CASP7 FAS 12444127 1017313 These data indicate that TCR ligation can activate nonapoptotic death programs in WT CD8 ( + ) and CD8 ( + ) T blasts that normally are masked by mediated [caspase] *activation* . Positive_regulation CASP7 FAS 12605597 1079486 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block and etoposide *induced* [caspase] activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation CASP7 FAS 12700647 1082035 Myriocin did not modulate the expression of CD95 or CD95L , instead , it interfered with the early steps of mediated [caspase] *activation* . Positive_regulation CASP7 FAS 12760867 1091403 This effect was correlated with an increase in mediated [caspase] *activation* and enhanced cleavage of the caspase substrate poly ( ADP-ribose ) polymerase . Positive_regulation CASP7 FAS 12760867 1091416 Furthermore , the positive effect on mediated [caspase] *activation* by IFN and ribavirin was confirmed by immunocytochemistry for activated caspase-3 and by immunoblot detection of activated caspase-3 , caspase-7 , and caspase-8 . Positive_regulation CASP7 FAS 12760867 1091429 IFN and ribavirin also enhance mediated [caspase] *activation* , which might in part be responsible for the apoptosis promoting effect of these antiviral compounds . Positive_regulation CASP7 FAS 12850790 1109577 Here , newly developed suicide genes , including *inducible* , inducible [caspase] and CD20 are discussed . Positive_regulation CASP7 FAS 12855571 1149824 Importantly , up-regulation of Gadd45 beta by CD40 precedes induced [caspase] *activation* , as well as up-regulation of other NF-kappa B-controlled inhibitors of apoptosis such as Bcl-xL and c-FLIPL . Positive_regulation CASP7 FAS 12938225 1133115 Co-incubation with cycloheximide partially reversed protection from apoptosis and increased *stimulated* initiator and effector [caspase] activation , suggesting new protein synthesis is necessary to induce protection upstream of caspase activation . Positive_regulation CASP7 FAS 14576776 1156543 The spontaneous death of CD4+ and CD8+ T cells was not prevented by a decoy CD95 receptor or by a broad-spectrum caspase inhibitor ( zVAD-fmk ) , suggesting that this form of cell death is independent of interaction and [caspase] *activation* . Positive_regulation CASP7 FAS 14675162 1189365 Both and anti-CD95 antibodies *triggered* [caspase] activation followed by apoptotic death in fully pro-inflammatory astrocytes , whereas resting cells were totally resistant . Positive_regulation CASP7 FAS 14690854 1194684 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , , and TRAIL receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP7 FAS 15197350 1347078 The inhibitory activity of TPCK was found to be death ligand-specific since TPCK inhibits TRAIL mediated caspase activity but does not affect *induced* [caspase] activity . Positive_regulation CASP7 FAS 15322156 1286766 Consistent with its role in cell death induction , deletion of caspase-8 in hepatocytes protected them from induced [caspase] *activation* and death . Positive_regulation CASP7 FAS 15648737 1350022 These findings suggest that mild hypothermia suppresses mediated apoptosis of liver cells by the partial inhibition of signaling events including mitochondrial damage , cytochrome c release , and subsequent apoptosome formation and effector [caspase] *activation* . Positive_regulation CASP7 FAS 15863130 1401086 Binding of Fas ligand or agonistic anti-Fas antibody to the death receptor can *activate* a [caspase-cascade] resulting in apoptosis . Positive_regulation CASP7 FAS 16120269 895978 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Positive_regulation CASP7 FAS 16384930 1547178 JAK2 mutated PV erythroblasts showed lower levels of *induced* [caspase] activation and incomplete caspase mediated cleavage of the erythroid transcription factor GATA-1 , which was entirely degraded in normal erythroblasts on CD95 stimulation . Positive_regulation CASP7 FAS 16527894 1574408 Simultaneously , mediated [caspase] *activation* precipitates differentiation . Positive_regulation CASP7 FAS 16646028 1557208 stimulation activated NF-kappaB and AP-1 , and this response *required* [caspase] activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation CASP7 FAS 17245429 1690843 The nucleo-cytoplasmic translocation of FLASH requires induced [caspase] *activation* and is facilitated by the Crm1 dependent nuclear export pathway . Positive_regulation CASP7 FAS 17304508 1718982 These results suggest the possible involvement of multiple signaling pathways from the MAPK to the subsequent mitochondria- and/or mediated [caspase] *activation* are potential requirements for PCA induced AGS apoptosis . Positive_regulation CASP7 FAS 18386902 1907143 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , [caspase] activation , and *induction* . Positive_regulation CASP7 FAS 18593565 1953611 *induced* [caspase] activation leads to degradation of gp130 , thereby suppressing IL-6 induced phosphorylation of STAT3 ( Tyr ( 705 ) ) and of tyrosine phosphatase SHP2 ( Tyr ( 580 ) ) . Positive_regulation CASP7 FAS 18948840 2041289 All *led* to a reduced DISC formation and diminished initiator [caspase] activity upon CD95-stimulation , whereas a marked heterogeneity in sensitivity to CD95 induced killing was found . Positive_regulation CASP7 FAS 19002587 1991272 In epithelial cells , induced hierarchic [caspase] *activation* is also linked with DEDD , a member of the DED family that binds to keratin (K) intermediate filaments ( IFs ) . Positive_regulation CASP7 FAS 19111607 2031768 However , recent studies have shown that can *induce* nonapoptotic [caspase independent cell death (CICD)] when caspase activity is inhibited . Positive_regulation CASP7 FAS 19680267 2157907 CD95 is a death receptor whose stimulation by either the physiologic ligand or the agonistic antibodies *leads* to the formation of a multi-molecular complex termed DISC ( death inducing signaling complex ) and the subsequent induction of a [caspase-driven] apoptotic signal . Positive_regulation CASP7 FAS 20876774 2368753 Simultaneous downregulation of c-FLIP ( L ) and c-FLIP ( S ) as well as individual knockdown of either isoform by RNA interference significantly enhances TRAIL ( tumour necrosis factor related apoptosis inducing ligand ) - and *induced* [caspase] activation and caspase dependent apoptosis . Positive_regulation CASP7 FAS 20926796 2343345 We describe a mechanism whereby NKG2D signaling in human T and NK cells initiates Fas mediated [caspase-3/-7] *activation* and resultant CD3? degradation . Positive_regulation CASP7 FAS 22543586 2750632 Furthermore , loss of RAGE increased expression of the death receptor CD95 ( Fas , Apo-1 ) , *dependent* [caspase] activation and extrinsic apoptosis , whereas NF-kB-p65 nuclear translocation was diminished . Positive_regulation CASP7 FAS 23029562 2681062 Blocking the ERK pathway using a pharmacological inhibitor increased the susceptibility of 661W cells to *induced* [caspase] activation and apoptosis . Positive_regulation CASP7 FAS 23530784 2762303 Various methods to inhibit apoptosis including the cell surface receptor pathway inhibitors , [caspase] *inhibitors* , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation CASP7 FAS 24622841 2930170 p53 mediated expression and subsequent downstream caspase-8 activation as well as p53 independent caspase-9 activation all *contribute* to the activation of the downstream effector [caspase-3/-7] , leading to tumor cell death . Positive_regulation CASP7 FAS 24928990 2946825 Real-time detection of CTL function reveals distinct patterns of [caspase] activation *mediated* by versus granzyme B . Positive_regulation CASP7 FAS 24928990 2946836 Remarkably , the *dependent* , [caspase 3/7] biosensor signal induced by perforin-deficient human CTLs was also detectable after a 90-min delay when measured by redirected killing . Positive_regulation CASP7 FAS 24928990 2946853 Thus , we have used a novel , real-time assay to demonstrate the distinct pattern of [caspase] activation *induced* by granzyme B versus in human and murine CTLs . Positive_regulation CASP7 FAS 9637489 513686 Here , we investigated whether the apoptosis occurring after TCR/CD9 stimulation is associated with a death pathway involving Fas stimulation and mediated [caspase] *activation* as observed in activation induced cell death ( AICD ) . Positive_regulation CASP7 FAS 9694885 524304 Our results demonstrate that whereas mediated activation of caspase 3 *requires* an upstream [caspase] activity that is zVAD-fmk-sensitive , the initial cleavage of caspase 3 during granule mediated cell death is insensitive to zVAD-fmk , suggesting that caspase 3 is cleaved directly by granzyme B in vivo . Positive_regulation CASP7 FOXO1 19902175 2197527 Diabetic wounds had increased TNF-alpha , fibroblast apoptosis , [caspase-3/7] activity and *activation* of the pro-apoptotic transcription factor , and decreased proliferating cell nuclear antigen positive fibroblasts ( p < 0.05 ) . Positive_regulation CASP7 IL1B 16305880 1485891 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , and interleukin-6 , and *activation* of caspase-1 , caspase-3 and [caspase-11] . Positive_regulation CASP7 IL1B 19037001 1998745 *caused* depletion of intracellular ATP , loss of mitochondrial transmembrane potential , [caspase-3/7] activation , and LDH release . Positive_regulation CASP7 MAOA 17883400 1830025 Two unrelated inhibitors *reduced* [caspase] activation . Positive_regulation CASP7 MAP2K6 16397410 1512988 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP7 MAP2K6 16672322 1583754 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* [caspase] activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only caspase activity . Positive_regulation CASP7 MAP2K6 21364665 2361138 dependent multiple [caspase] *activation* by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP7 MMP28 13679861 1140613 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP7 MMP7 13679861 1140628 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP7 RNASE1 15620724 1357839 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and *induced* [caspase] activation in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP7 RNASE1 15620724 1358073 We find that RC-RNase and *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP7 RNASE7 15620724 1357847 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and induced [caspase] *activation* in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP7 RNASE7 15620724 1358081 We find that RC-RNase and *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP7 SPHK1 11238741 791090 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Positive_regulation CASP7 TNF 10425195 632761 *induces* [caspase] activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation CASP7 TNF 10586080 571806 Silymarin also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated *induced* cytotoxicity and [caspase] activation . Positive_regulation CASP7 TNF 10593992 572964 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Positive_regulation CASP7 TNF 10764744 698799 Addition of H ( 2 ) O ( 2 ) prevented induced apoptosis and [caspase] *activation* , an effect prevented by simultaneous addition of catalase . Positive_regulation CASP7 TNF 10820260 694393 induced cytotoxicity , [caspase] *activation* , and lipid peroxidation were also abolished by vesnarinone . Positive_regulation CASP7 TNF 10843709 700179 Resveratrol also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated *induced* cytotoxicity and [caspase] activation . Positive_regulation CASP7 TNF 11112424 757613 *caused* a rapid activation of [caspase-8 and -7] in cells transfected with a vector . Positive_regulation CASP7 TNF 11112424 757618 Overexpression of PKC eta delayed the *activation* of [caspase-8 and -7] by both and the combination of BIM and TNF . Positive_regulation CASP7 TNF 11228746 581010 induced *activation* of [caspase] activity was blocked by all three types of quenchers . Positive_regulation CASP7 TNF 11847111 912598 mediated [caspase] *activation* and block of differentiation are dependent upon the expression of PW1 , but occur independently of NFkappaB activation . Positive_regulation CASP7 TNF 12036088 949071 *promotes* [caspase] activation and apoptosis in human fetal membranes . Positive_regulation CASP7 TNF 12080044 976124 We also showed that stable overexpression of A20 inhibits apoptosis and [caspase] activation *induced* by . Positive_regulation CASP7 TNF 12431778 1015388 Our results demonstrate that TGF-beta1 can decrease TNF-alpha induced apoptosis in murine osteoblasts at least in part by attenuating *induced* [caspase] gene expression . Positive_regulation CASP7 TNF 12663669 1092680 In the presence of cycloheximide , or interleukin-1 *initiates* [caspase] activation , loss of mitochondrial membrane potential ( DeltaPsi ) , DNA degradation , and nuclear condensation and fragmentation characteristic of apoptotic cell death in human vascular endothelial cells ( EC ) . Positive_regulation CASP7 TNF 12763364 1093895 The latter and mediated [caspase] *activation* was attenuated by prostaglandin E ( 2 ) . Positive_regulation CASP7 TNF 12800192 1098919 The antioxidants N-acetylcysteine , reduced glutathione , lipoic acid and ascorbic acid markedly reduced the enhancing effect of the hormone on induced [caspase] *activation* . Positive_regulation CASP7 TNF 12800192 1098932 The effect of calcitriol on DeltaPsi was mimicked by rotenone , which increased both the drop in DeltaPsi and [caspase] activation *induced* by . Positive_regulation CASP7 TNF 15033766 1184113 The antioxidants N-acetylcysteine , glutathione , lipoic acid , and ascorbic acid markedly reduced the effect of the hormone on *induced* [caspase] activation , attesting to the involvement of reactive oxygen species ( ROS ) in the cross-talk between the hormone and the cytokine . Positive_regulation CASP7 TNF 15283855 1277826 In the *presence* of or endotoxin ( LPS ) , blockade of CD18 ( beta2 chain ) with mAb markedly increased [caspase] activation in PMN on fibrinogen . Positive_regulation CASP7 TNF 15452110 1341978 These mutant cells exhibited a defect in induced [caspase] *activation* , Bid cleavage , and release of cytochrome c . Positive_regulation CASP7 TNF 16532377 1555289 Inhibition of the p38 and/or the JNK death pathways reduced [caspase] activation *induced* by oxidative stress , hyperosmotic shock and . Positive_regulation CASP7 TNF 16631528 1552355 We report that DDC strongly inhibits [caspase] activation , loss of DeltaPsim , and cell death *induced* by or etoposide . Positive_regulation CASP7 TNF 17038555 1674592 *increased* [caspase 3/7] activity ( an indicator of apoptosis ) and decreased cell viability dose and time dependently . Positive_regulation CASP7 TNF 17047073 1635893 Importantly , down-regulation of TRAIL by small interfering RNA silencing decreased mediated Adriamycin induced [caspase] *activation* and apoptosis , and thus enhanced breast cancer cell resistance to Adriamycin . Positive_regulation CASP7 TNF 17125837 1686484 ATD5 could also reduce the TNF-alpha mediated cytotoxicity and inhibit mediated [caspase] *activation* on L929 cells in a dose dependent manner . Positive_regulation CASP7 TNF 17438131 1742790 Interference by alpha-4 DND or alpha-4 siRNA increased [caspase 3/7] activation in *response* to . Positive_regulation CASP7 TNF 17599041 1848498 We have recently shown that *induces* [caspase dependent and -independent] JNK activation and ROS accumulation in cellular FLICE-inhibitory protein ( c-Flip ) ( -/- ) murine embryonic fibroblasts ( MEFs ) . Positive_regulation CASP7 TNF 18023359 1832135 Mitochondrial apoptotic inducer bax , and the suppressor bcl-2 were evaluated using western blotting at 48 h. Results indicated that *increased* [caspase] activities and resulted in a significant ( p = 0.001 ) increase in bax/bcl-2 ratio . Positive_regulation CASP7 TNF 18331441 1904679 TNF-alpha ( 10 ( -8 ) mol/L ) treatment showed small but significant increases of caspase 3/7 activity in RPTEC , and AT1 and AT2 receptor blockers ( 10 ( -8 ) mol/L ) comparably decreased *induced* [caspase 3/7] activity . Positive_regulation CASP7 TNF 18467439 1938882 However , XIAP small interfering RNA restored *induced* [caspase] signaling and apoptosis in Hec-1A cells ; Positive_regulation CASP7 TNF 19345705 2094387 Finally , reconstitution of PPT1 activity in mutant cells was accompanied by resensitization to *induced* [caspase] activation and toxicity . Positive_regulation CASP7 TNF 19440308 2078413 Muscle regeneration is , at least in part , regulated by caspase activation , and AVP abrogated dependent [caspase] *activation* . Positive_regulation CASP7 TNF 20200974 2299816 Silencing FOXO1 using siRNA in vitro significantly reduced *induced* apoptosis and [caspase] activity in differentiated chondrocytes . Positive_regulation CASP7 TNF 21269505 2392750 is also *required* for appropriate regulation of [caspase] genes . Positive_regulation CASP7 TNF 21893119 2506486 Conversely , *activation* of [caspase] by exogenous required IL-13 , TWEAK , and Fn14 . Positive_regulation CASP7 TNF 22471953 2637170 a-MSH and [ DTRP ( 8 ) ] -?-MSH treatment , for 30 min before TNF-a stimulation , provided a time-and-bell shaped concentration dependent decrease in pro-inflammatory cytokines ( IL-1ß , IL-6 and IL-8 ) release and increased release of the chondroprotective and anti-inflammatory cytokine , IL-10 , whilst decreasing expression of MMP1 , MMP3 , MMP13 genes.a-MSH and [ DTRP ( 8 ) ] -?-MSH treatment also inhibited induced [caspase-3/7] *activation* and chondrocyte death . Positive_regulation CASP7 TNF 22721505 2681851 The antioxidant resveratrol abolished *induced* increase in ROS production and [caspase-3/7] activity , but apoptosis was only partially prevented . Positive_regulation CASP7 TNF 24684347 2935145 Smac-mimetic 1-induced loss of cIAPs correlated with inhibition of mediated NF-?B activation , [caspase] *activation* , and tumor cell killing . Positive_regulation CASP7 TNF 9531309 496832 Furthermore , only murine but not IL-1alphabeta *increased* [caspase] activity and apoptosis . Positive_regulation CASP7 TNF 9885230 584459 *induced* [caspase] activation was accompanied by a decrease in the ability of neutrophils to release superoxide anion . Positive_regulation CASP7 TNF 9885230 584485 Granulocyte-macrophage colony stimulating factor inhibited *induced* [caspase] activation and apoptosis , while reversing the diminution in superoxide release . Positive_regulation CASP7 TNFSF10 11677236 896125 Combining and interferon in vitro , synergistically *induced* apoptosis and [caspase] activation in breast cancer cells . Positive_regulation CASP7 TNFSF10 11911810 924234 Similarly , *activated* caspase-3 and [caspase-7] in control cells but not in cells expressing Bcl-2 or Bcl-xL . Positive_regulation CASP7 TNFSF10 12815069 1103421 In addition , overexpression of cleavage-site mutant c-IAP1 makes cells more resistant to *induced* [caspase] activation . Positive_regulation CASP7 TNFSF10 14644092 1188261 Furthermore , the enhancement extended to *induced* [caspase-activation] . Positive_regulation CASP7 TNFSF10 14690854 1194685 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , Fas , and receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP7 TNFSF10 15197350 1347065 In this study , we show that TPCK inhibits *induced* [caspase] activity but potentiates wortmannin dependent caspase activity in prostatic carcinoma cell lines . Positive_regulation CASP7 TNFSF10 15558024 1361132 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both promoted by amiloride . Positive_regulation CASP7 TNFSF10 15569667 1368292 Here we demonstrate that human breast cancer cells , but not normal mammary epithelial cells , are dramatically sensitized to *induced* apoptosis and [caspase] activation by peroxisome proliferator activated receptor gamma ( PPARgamma ) agonists of the thiazolidinedione ( TZD ) class . Positive_regulation CASP7 TNFSF10 16103097 1444527 Generation of ROS by CCCP was responsible for *induced* Bax and [caspase] activation because scavenging ROS completely abrogated apical caspase-8 activation and further downstream events leading to cell death . Positive_regulation CASP7 TNFSF10 17031854 1700281 Here we demonstrated that human prostate cancer cells , but not normal prostate cells , are dramatically sensitized to *induced* apoptosis and [caspase] activation by quercetin . Positive_regulation CASP7 TNFSF10 17031854 1700294 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both enhanced by quercetin . Positive_regulation CASP7 TNFSF10 17545549 1751980 We isolated primary tumor cells from 13 astrocytoma and oligoastrocytoma patients of all four WHO grades of malignancy and compared the levels of *induced* apoptosis induction , long-term tumor cell survival , [caspase] , and caspase target cleavage . Positive_regulation CASP7 TNFSF10 17706603 1789071 6-Gingerol facilitated TRAIL induced apoptosis by increasing induced [caspase-3/7] *activation* . Positive_regulation CASP7 TNFSF10 17724141 1822426 Rituximab , a CD20 antibody used to treat certain types of NHL , augmented induced [caspase] *activation* in Ramos RA1 and DoHH2 but not BJAB or SC-1 cells , through modulation of intrinsic rather than extrinsic apoptosis signaling . Positive_regulation CASP7 TNFSF10 17804742 1791213 Although the proteolytic processing of procaspase-3 by TRAIL was partially blocked in glioma cells , cotreatment with silibinin efficiently recovered *induced* [caspase] activation in these cells . Positive_regulation CASP7 TNFSF10 18483385 1910832 Aspirin sensitized human breast cancer cells , but not untransformed human mammary epithelial cells , to *induced* [caspase] activation and apoptosis by a cyclooxygenase-2 independent mechanism . Positive_regulation CASP7 TNFSF10 18665234 1943064 Stable knockdown of bid lead to a pronounced resistance to Fas/CD95- and *induced* [caspase] activation and apoptosis , and significantly increased clonogenic survival . Positive_regulation CASP7 TNFSF10 18980244 1995227 While the proteolytic processing of procaspase-3 by TRAIL was partially blocked in various HCC cells treated with TRAIL alone , co-treatment with quercetin efficiently recovered *induced* [caspase] activation . Positive_regulation CASP7 TNFSF10 20400979 2274065 The ability of ovarian cancer ascites to activate Akt and inhibit *induced* cell death and [caspase] activity was decreased by heat inactivation , but was retained in ascites fractions > 5 kDa . Positive_regulation CASP7 TNFSF10 20400979 2274078 These results suggest that ovarian cancer ascites induces FAK and Akt activation in an alphavbeta5 integrin dependent pathway , which confers protection from induced cell death and [caspase] *activation* . Positive_regulation CASP7 TNFSF10 21109947 2366201 induced [caspase/p38] *activation* is responsible for the increased catalytic and invasive activities of Akt . Positive_regulation CASP7 TNFSF10 22991197 2734934 We demonstrate that EGFR targeted in combination with BZB *induced* significantly higher [caspase] activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation CASP7 TNFSF10 23180246 2723794 *induces* autophagic protein cleavage through [caspase] activation in melanoma cell lines under arginine deprivation . Positive_regulation CASP7 TNFSF10 24525736 2914814 Treatment of hepatoma cells with salubrinal , an inhibitor of eIF2a dephosphorylation , enhances *induced* eIF2a phosphorylation , CCAAT/enhancer binding protein homologous protein ( CHOP ) expression and [caspase] activation . Positive_regulation CASP7 TNFSF10 24525736 2914828 Moreover , knockdown of growth arrest and DNA damage-inducible protein 34 ( GADD34 ) , which recruits protein phosphatase 1 to dephosphorylate eIF2a , enhances induced eIF2a phosphorylation , CHOP expression , [caspase] *activation* and apoptosis . Positive_regulation CASP7 TNFSF10 24525736 2914842 Knockdown of CHOP abrogates the stimulation of *induced* [caspase] activation and apoptosis by salubrinal . Positive_regulation CASP8 CAPN8 11449356 836283 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Positive_regulation CASP8 CAPN8 12358768 994423 Calpain inhibitor III ( MDL-28170 ) reduced caspase activation , suggesting that [caspase] activation was *mediated* by . Positive_regulation CASP8 CAPN8 12917442 1151119 Interestingly , the overexpression of parkin induced the activation of an intracellular cysteine protease , calpain , but not [caspase] , and the cytoprotective effect of parkin on alpha-synuclein cytotoxicity was significantly *inhibited* by the presence of inhibitors . Positive_regulation CASP8 CAPN8 16597613 1604316 However , PD-150606 also attenuated caspase-3 activity and apoptosis at 24 h , suggesting *dependent* [caspase] activation . Positive_regulation CASP8 CAPN8 19646546 2157646 The results suggest that procaspase-8 and FLIP ( S ) association with cell membrane receptor complexes is required for *induced* [caspase-8] activation . Positive_regulation CASP8 CCND1 12480939 1078958 Bcl-2 controls [caspase] activation *following* a p53 dependent death signal . Positive_regulation CASP8 CCND1 19998418 2280761 Cell death induced by the extract of P. linteus grown on PBR was shown to be associated with the upregulation of p21 ( CIP1/WAF1 ) , the downregulation of , anti-apoptotic protein , Bcl-2 , the release of cytochrome c , and the *activation* of caspase-9 , caspase-3 and [caspase-8] . Positive_regulation CASP8 EPHB2 12122017 984988 Head involution defective ( Hid ) -triggered apoptosis requires [caspase-8] but not FADD ( Fas associated death domain ) and is *regulated* by in mammalian cells . Positive_regulation CASP8 EPHB2 15304372 1322274 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Positive_regulation CASP8 EPHB2 16397410 1512990 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP8 EPHB2 16538383 1555316 Accordingly , prolonged stimulation *activated* [caspase 8] and strongly potentiated Fas signaling . Positive_regulation CASP8 EPHB2 16538383 1555320 These findings reveal that prolonged stimulation *results* in [caspase 8] activation and cell death . Positive_regulation CASP8 EPHB2 17192846 1701823 These effects were paralleled by disruption of Ras -- > and Akt survival pathways , consequent decreased phosphorylation of both mitochondrial bcl-2 and bad proteins , and [caspase] *activation* . Positive_regulation CASP8 EPHB2 19709398 2139144 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Positive_regulation CASP8 EPHB2 20177944 2236721 This [caspase] activation is *mediated* by phosphorylation of Akt and . Positive_regulation CASP8 EPHB2 20404718 2246105 Since sustained activation can *activate* [caspase-8] in some cell types , we studied the role of ERK in Vpr induced caspase-8 activation . Positive_regulation CASP8 EPHB2 21364665 2361140 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP8 EPHB2 21854868 2500973 Taken together , our data indicate that mediated caspase-8 activation and Fas/FasL mediated [caspase-8] *activation* mostly elucidate doxorubicin induced death in MCF-7 cells and MCF-7/Dox cells , respectively . Positive_regulation CASP8 EPHB2 22193398 2543490 Overexpression of ZnT-1 markedly reduced LDH release and caspase activation following I/R. Knockdown of endogenous ZnT-1 augmented the I/R induced release of LDH and increased [caspase] *activation* following I/R. levels were significantly increased following I/R in cells overexpressing ZnT-1 , while knockdown of ZnT-1 reduced phospho-ERK levels . Positive_regulation CASP8 EPHB2 22554503 2590598 The activation of increased XIAP expression and *led* to decreased [caspase] activation . Positive_regulation CASP8 FAS 10194469 603890 signaling to the mitochondria *required* [caspase-8] , whereas cytochrome c release in response to DNA damage was caspase independent . Positive_regulation CASP8 FAS 10196099 604259 DISC formation is the first essential step of signaling and *results* in activation of [caspase-8] starting a signaling cascade that leads to apoptosis . Positive_regulation CASP8 FAS 10200473 561095 Cell death attenuation by 'Usurpin ' , a mammalian DED-caspase homologue that precludes [caspase-8] recruitment and *activation* by the ( Fas , APO-1 ) receptor complex . Positive_regulation CASP8 FAS 10213689 608078 *induced* [caspase] denitrosylation . Positive_regulation CASP8 FAS 10235259 611644 The CED-4-homologous protein FLASH is involved in *mediated* activation of [caspase-8] during apoptosis . Positive_regulation CASP8 FAS 10352269 617211 In strict contrast , TPA is an ineffective inhibitor when cell death is induced by the potassium ionophore valinomycin , the specific mitochondrial benzodiazepine ligand PK11195 , or by primary [caspase] *activation* by cross linking . Positive_regulation CASP8 FAS 10364198 620471 EGF stimulation of epithelial cells also inhibited induced [caspase] *activation* and the proteolysis of signaling proteins downstream of the EGF receptor , Cbl and Akt/protein kinase B ( Akt ) . Positive_regulation CASP8 FAS 10391681 626720 ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , [caspase] activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation CASP8 FAS 10391681 626736 M3/6 prevented Fas stimulation of JNK , but did not affect mediated [caspase] *activation* or cell death , demonstrating that JNK activation is not required for these processes . Positive_regulation CASP8 FAS 10405325 629347 induced [caspase] *activation* and nuclear apoptosis , however , were unaffected by the depletion of ATP . Positive_regulation CASP8 FAS 10464143 640284 Suppression of *induced* activation of the [caspase] by IL-1beta was diminished by coadministration with D-galactosamine and reversed by coinjection with an excess amount of uridine . Positive_regulation CASP8 FAS 10545115 564286 Taken together , these findings argue that hDaxx promotes sensitivity to Fas from a nuclear location , probably by modulating the transcription of genes involved in *induced* [caspase] activation and apoptosis . Positive_regulation CASP8 FAS 10706558 673185 In conclusion , in vivo stimulation *causes* [caspase] activation , mitochondrial permeability transition ( decreasing the membrane potential and increasing basal respiration ) , mitochondrial matrix expansion ( as shown by matrix herniation ) , outer mitochondrial membrane rupture , and cytochrome c release . Positive_regulation CASP8 FAS 10713706 676264 We provide evidence that both , radiation and stimulation , *induce* the rapid activation of [caspase-8] and BID followed by apoptosis in Jurkat T-cells . Positive_regulation CASP8 FAS 10744730 680734 Repression of *induced* [caspase-8] activation . Positive_regulation CASP8 FAS 10749152 681135 These results indicate that mediated [caspase] *activation* elicits two independent cellular responses ; Positive_regulation CASP8 FAS 10766189 684366 The caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp ( OMe ) fluoromethyl ketone ( zVADfmk ) , at concentrations that completely prevent apoptosis and [caspase] activation *induced* by ligation of the death receptor , had only a partial protective effect on onconase induced cell death . Positive_regulation CASP8 FAS 10802053 691669 Two different receptor *induced* apoptotic pathways are presently known in other cell types : ( i ) direct activation of [caspase-8] and ( ii ) induction of ceramide mediated mitochondrial activation , both leading to subsequent caspase-3 activation . Positive_regulation CASP8 FAS 10837247 699342 Activation of ( CD95 ) by its ligand ( FasL ) rapidly *induces* cell death through recruitment and activation of [caspase-8] via the adaptor protein Fas associated death domain protein ( FADD ) . Positive_regulation CASP8 FAS 10845905 700696 IFN-gamma induced Fas expression of the cells without the activation of caspase8 or caspase3 during 16 hours of incubation , while deprivation of EPO induced expression of and the *activation* of both [caspase8] and caspase3 . Positive_regulation CASP8 FAS 10852976 704096 Interestingly , ligation *activated* [caspase-8] and caspase-3 with the cleavage of poly ( ADP-ribose ) polymerase ( PARP ) , corresponding to apoptosis of RA synoviocytes . Positive_regulation CASP8 FAS 10933582 720322 Bid is a novel pro-apoptosis Bcl-2 family protein that is activated by [Caspase 8] in *response* to death receptor activation . Positive_regulation CASP8 FAS 10958671 724902 To examine the consequences of maintaining the structural integrity of BAP31 during apoptosis , the caspase recognition aspartate residues were mutated to alanine residues , and *mediated* activation of [caspase 8] and cell death were examined in human KB epithelial cells stably expressing the caspase-resistant mutant crBAP31 . Positive_regulation CASP8 FAS 11032168 740242 Bid is a novel pro-apoptosis Bcl-2 family protein that is activated by [caspase 8] in *response* to death receptor signals . Positive_regulation CASP8 FAS 11059759 746282 Furthermore , IFN-gamma sensitized MCF-7 and MDA-MB231 cells to *mediated* activation of [caspase-8] , induction of cytochrome c release from mitochondria , and processing of caspase-9 . Positive_regulation CASP8 FAS 11059778 746290 Induction of apoptosis in MGMT- cells was not triggered by and Fas ligand ( CD95 , Apo-1 ) because both proteins remained unaltered in expression and receptor-proximal [caspase-8] was not *activated* after methylation . Positive_regulation CASP8 FAS 11245678 793224 Increased levels of death receptor , Bax , and cytochrome c , *activation* of [caspase 8] , and abnormalities in mitochondria in the thalamus significantly precede the activation of caspase 3 and the appearance of neuronal apoptosis at 24 hr . Positive_regulation CASP8 FAS 11259186 795744 The MC159 expressing virus blocked induced *activation* of [caspase-3 and -8] , degradation of PARP , and cleavage of DNA , whereas the parental vaccinia virus did not . Positive_regulation CASP8 FAS 11260077 796096 ligation increased apoptosis and decreased colony growth equally in RARS and controls , but *caused* significantly more [caspase] activation in RARS ( P < 0.01 ) . Positive_regulation CASP8 FAS 11278283 819070 Staurosporine activates MST either caspase-dependently or independently , whereas ligation *activates* it only [caspase-dependently] . Positive_regulation CASP8 FAS 11295536 801390 NH ( 2 ) Cl pretreatment significantly inhibited apoptosis and [caspase] activation *induced* by etoposide or camptothecin , a DNA topoisomerase I poison , but not by staurosporine or stimulation . Positive_regulation CASP8 FAS 11322649 807154 Gamma-interferon ( IFN-gamma ) augments apoptotic response to mistletoe lectin-II via upregulation of L expression and [caspase] *activation* in human myeloid U937 cells . Positive_regulation CASP8 FAS 11337381 812184 Thus , the Apert S252W FGFR-2 mutation promotes apoptosis in human osteoblasts through activation of protein kinase C , overexpression of IL-1 and , *activation* of [caspase-8] , and increased Bax/Bcl-2 levels , leading to increased effector caspases and DNA fragmentation . Positive_regulation CASP8 FAS 11352849 814896 Albumin overload also resulted in a dose dependent upregulation of and Fas associated protein with death domain ( FADD ) , and *activation* of [caspase 8] . Positive_regulation CASP8 FAS 11359796 816305 In isolated GC B cells , cFLIP ( L ) decays rapidly even without ligation , and this *results* in activation of [caspase] activity and apoptosis . Positive_regulation CASP8 FAS 11368434 817081 *induced* [caspase] activity is increased in RARS bone marrow cells . Positive_regulation CASP8 FAS 11495678 846264 These data suggest that apoptosis by SOM may occur by a Bax- and NO-independent p53 accumulation , and through Fas and caspase-8 activation pathways , and that the inducible expression of Bcl-2 and NO production by SP may contribute to prevent the signals of apoptosis by Bax , and via and [caspase-8] *activation* . Positive_regulation CASP8 FAS 11536010 854850 We conclude that ( i ) synergistic induction of apoptosis by C2-ceramide and CD95L depend on a cross-talk between the two signal transduction pathways and that ( ii ) C2-ceramide , independently of its sensitizing effects on *dependent* [caspase] activation , is also capable of triggering an apoptotic signaling cascade that is unaffected by zVAD-fmk mediated caspase inhibition , but promoted by high levels of CD95 expression . Positive_regulation CASP8 FAS 11551934 882155 PI3-kinase inhibition sensitized to apoptosis by increasing and accelerating mediated [caspase] *activation* . Positive_regulation CASP8 FAS 11673515 872830 Thus , *induced* initiation of [caspase] activity at the plasma membrane may in some cells result in local proteolysis of submembrane proteins , leading to generation of membrane vesicles that are highly enriched in active caspase 8 . Positive_regulation CASP8 FAS 11698497 878166 Interleukin (IL)-5 and interferon (IFN)-gamma , two cytokines known to prolong eosinophil survival , inhibited mediated apoptosis and [caspase] *activation* but poorly affected the decrease in DeltaPsi ( m ) . Positive_regulation CASP8 FAS 11699200 878336 Recent work has demonstrated that the degree of spontaneous caspase activation in FHL lymphocytes is attenuated in vitro whereas mediated [caspase] *activation* and apoptosis induction remains unmitigated , and FHL can thus be distinguished from the related chronic disorder of immune regulation termed autoimmune lymphoproliferative syndrome or ALPS . Positive_regulation CASP8 FAS 11739185 886106 However , pretreatment with chelerythrin , but not with calphostin C , resulted in the restoration of *induced* [caspase-8] activation and cytotoxicity , suggesting that some atypical protein kinase C ( PKC ) isoforms contributed to the lack of DISC formation . Positive_regulation CASP8 FAS 11739185 886107 Indeed , treatment with antisense oligonucleotides directed against PKC zeta and enforced expression of Par-4 , a negative regulator of PKC zeta activity , restored *induced* [caspase-8] activity and apoptosis . Positive_regulation CASP8 FAS 11801595 922391 In the present studies , we found that stimulation of receptors , with either agonistic antibody or CD95 ligand , *resulted* in the activation of [caspase-8] , which in turn processed caspase-3 between its large and small subunits . Positive_regulation CASP8 FAS 11834943 911170 Lamivudine was also found to stimulate in vitro *induced* apoptosis and [caspase] activation in pre activated T lymphocytes from healthy donors . Positive_regulation CASP8 FAS 11859150 914807 In this report , we demonstrate that beta ( 1 ) integrin mediated adhesion to fibronectin inhibits *induced* [caspase-8] activation and apoptosis in hematologic tumor cell lines . Positive_regulation CASP8 FAS 12165276 972789 Further investigation of *mediated* [caspase] activities revealed that supplementation of glutamine significantly decreased caspase-3 and caspase-8 activities in activated T cells . Positive_regulation CASP8 FAS 12207331 983596 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Positive_regulation CASP8 FAS 12215208 985998 one involves death receptors and is exemplified by mediated [caspase-8] *activation* , and another is the stress- or mitochondria mediated caspase-9 activation pathway . Positive_regulation CASP8 FAS 12221075 998200 Enforced expression of GPx1 also resulted in inhibition of *induced* effector [caspase] activation , DNA fragmentation , and apoptotic cell death . Positive_regulation CASP8 FAS 12393561 1035695 Moreover , we have previously reported that G-CSF inhibits induced [caspase] *activation* in sideroblastic anemia ( RARS ) . Positive_regulation CASP8 FAS 12393594 1031528 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Positive_regulation CASP8 FAS 12404126 1009730 Structure-function analysis determined that ATP hydrolysis was necessary for P-gp to confer resistance to induced [caspase] *activation* and cell death . Positive_regulation CASP8 FAS 12404126 1009737 These studies demonstrate that P-gp inhibits *induced* [caspase-8] activation but not formation of the DISC and that this activity of P-gp is dependent on ATP hydrolysis . Positive_regulation CASP8 FAS 12441076 1017051 An increase in the amount of Fas ( APO-1/CD95 ) , [caspase-8] *activation* , caspase-8 mediated Bid cleavage , and subsequent translocation of truncated Bid to mitochondria , all of which relate to the Fas mediated pathway , also occurred in MHV infected 17Cl-1 cells , whereas the formation of the death inducing signaling complex , a direct indication of the activation of mediated pathway , was undetectable . Positive_regulation CASP8 FAS 12444127 1017314 These data indicate that TCR ligation can activate nonapoptotic death programs in WT CD8 ( + ) and CD8 ( + ) T blasts that normally are masked by mediated [caspase] *activation* . Positive_regulation CASP8 FAS 12477725 1056082 One other important finding is that spermatogenic cells are type II cells , as the increase in expression in the spermatogenic cells is *followed* by the cleavage of [caspase-8] to its active form , following which Bax translocates to the mitochondria and precipitates the release of cytochrome c that is accompanied by a drop in mitochondrial potential . Positive_regulation CASP8 FAS 12605597 1079487 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block and etoposide *induced* [caspase] activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation CASP8 FAS 12657720 1073318 Thus , Z-FA-fmk fails to inhibit *mediated* activation of [caspase 8] , but completely inhibits RRM induced processing of caspase 8 . Positive_regulation CASP8 FAS 12700647 1082036 Myriocin did not modulate the expression of CD95 or CD95L , instead , it interfered with the early steps of mediated [caspase] *activation* . Positive_regulation CASP8 FAS 12704141 1082317 Our results show that up-regulation is *followed* by early activation of [caspase-8] and -3 and cleavage of the caspase-3 substrate poly ( ADP-ribose ) polymerase . Positive_regulation CASP8 FAS 12760867 1091404 This effect was correlated with an increase in mediated [caspase] *activation* and enhanced cleavage of the caspase substrate poly ( ADP-ribose ) polymerase . Positive_regulation CASP8 FAS 12760867 1091417 Furthermore , the positive effect on mediated [caspase] *activation* by IFN and ribavirin was confirmed by immunocytochemistry for activated caspase-3 and by immunoblot detection of activated caspase-3 , caspase-7 , and caspase-8 . Positive_regulation CASP8 FAS 12760867 1091430 IFN and ribavirin also enhance mediated [caspase] *activation* , which might in part be responsible for the apoptosis promoting effect of these antiviral compounds . Positive_regulation CASP8 FAS 12850790 1109578 Here , newly developed suicide genes , including *inducible* , inducible [caspase] and CD20 are discussed . Positive_regulation CASP8 FAS 12855571 1149825 Importantly , up-regulation of Gadd45 beta by CD40 precedes *induced* [caspase] activation , as well as up-regulation of other NF-kappa B-controlled inhibitors of apoptosis such as Bcl-xL and c-FLIPL . Positive_regulation CASP8 FAS 12861043 1111699 Neither [caspase-8] nor caspase-3 was activated by agonistic anti-Fas antibody alone , but both caspases were *activated* by stimulation in the presence of ActD or CHX , indicating the importance of caspase-8 inhibitors that are sensitive to metabolic inhibitors . Positive_regulation CASP8 FAS 12930371 1132334 Analysis of induced *activation* of [caspase-8] and -9 showed decreased activity of both caspases in HT , whereas activity of caspase-9 was increased and that of caspase-8 was decreased in GD . Positive_regulation CASP8 FAS 12938225 1133116 Co-incubation with cycloheximide partially reversed protection from apoptosis and increased *stimulated* initiator and effector [caspase] activation , suggesting new protein synthesis is necessary to induce protection upstream of caspase activation . Positive_regulation CASP8 FAS 12959751 1138351 Virally encoded genes inhibit the *activation* of [caspase-8] by the TNF receptor and ; Positive_regulation CASP8 FAS 13679375 1164642 In experiments done in Jurkat T cells and activated peripheral blood T lymphocytes , engagement of alpha2beta1 integrin with collagen type I ( Coll I ) was found to significantly reduce *induced* apoptosis and [caspase-8] activation ; Positive_regulation CASP8 FAS 13679375 1164644 Furthermore , we found that activation of protein phosphatase 2A (PP2A) by Coll I was required for both Coll I-mediated activation of Erk , and inhibition of *induced* [caspase-8] activation and apoptosis . Positive_regulation CASP8 FAS 14499341 1143689 Activation of receptor by Fas ligand *causes* [caspase 8] activation and apoptosis in cells and is an important mechanism by which normal tissue homeostasis and function are maintained . Positive_regulation CASP8 FAS 14576776 1156544 The spontaneous death of CD4+ and CD8+ T cells was not prevented by a decoy CD95 receptor or by a broad-spectrum caspase inhibitor ( zVAD-fmk ) , suggesting that this form of cell death is independent of interaction and [caspase] *activation* . Positive_regulation CASP8 FAS 14646514 480074 [Caspase-8] ( FLICE ) can associate with and be *activated* by ( APO-1/Fas ) , an apoptosis inducing member of the Tumour Necrosis Factor receptor family . Positive_regulation CASP8 FAS 14675162 1189366 Both and anti-CD95 antibodies *triggered* [caspase] activation followed by apoptotic death in fully pro-inflammatory astrocytes , whereas resting cells were totally resistant . Positive_regulation CASP8 FAS 14688367 1190737 However , activation *resulted* in [caspase-8] activation and apoptosis only in the presence of cycloheximide ( CHX ) . Positive_regulation CASP8 FAS 14690854 1194686 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , , and TRAIL receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP8 FAS 14992818 1215727 Cellular FLICE inhibitory protein-long ( c-FLIP-L ) is an endogenous inhibitor of the *activation* of [caspase 8] by . Positive_regulation CASP8 FAS 14992818 1215728 Overexpression of c-FLIP-L rAAV inhibited cleavage of [caspase 8] *induced* by antibody treatment . Positive_regulation CASP8 FAS 15144569 1247587 After HuIFN-beta exposure , COH and CC-M2 cells showed increased levels of and FasL proteins , alteration of mitochondrial membrane potential , and *activation* of caspase-9 , [caspase-8] , and caspase-3 in a time dependent manner . Positive_regulation CASP8 FAS 15161627 1252857 *Activation* of [caspase 8] by engagement markedly increased the probe 's cleavage , whereas treatment of caspase 8-deficient cells with anti-Fas did not increase cleavage . Positive_regulation CASP8 FAS 15192017 1295274 To investigate this possibility , we studied the influence of bovine lactoferrin on Fas mediated apoptosis with regard to expression of , *activation* of [caspase-8] and caspase-3 , and DNA fragmentation in the colon mucosa of AOM treated rats . Positive_regulation CASP8 FAS 15197350 1347079 The inhibitory activity of TPCK was found to be death ligand-specific since TPCK inhibits TRAIL mediated caspase activity but does not affect *induced* [caspase] activity . Positive_regulation CASP8 FAS 15207716 1261661 We report here that disruption of lipid rafts by cholesterol depleting compounds ( methyl-beta-cyclodextrin , filipin III , cholesterol oxidase , and mevastatin ) leads to a spontaneous clustering of Fas in the non-raft compartment of the plasma membrane , formation of complexes , *activation* of [caspase-8] , and apoptosis . Positive_regulation CASP8 FAS 15214041 1262840 Similarly , cross linking *resulted* in caspase independent translocation of FADD/MORT1 and [caspase-8] to the lipid rafts , which was prevented by a death domain-defective receptor . Positive_regulation CASP8 FAS 15302575 1283935 We found that while HLA-DR signaling does not affect Fas receptor expression , it significantly reduces *induced* activation of [caspase-8] and Bid . Positive_regulation CASP8 FAS 15322156 1286767 Consistent with its role in cell death induction , deletion of caspase-8 in hepatocytes protected them from *induced* [caspase] activation and death . Positive_regulation CASP8 FAS 15540114 1355187 Here , we show that treatment with the histone deacetylase (HDAC) inhibitor FR901228 renders Fas-resistant osteosarcoma cell lines sensitive to Fas mediated apoptosis by downregulating expression of cellular FLIP ( cellular FLICE-inhibitory protein ) , an inhibitor of *mediated* activation of [caspase-8] . Positive_regulation CASP8 FAS 15572410 1344294 p38alpha , but not p38beta , inhibits the phosphorylation and presence of c-FLIPS in DISC to potentiate mediated [caspase-8] *activation* and type I apoptotic signaling . Positive_regulation CASP8 FAS 15648737 1350023 These findings suggest that mild hypothermia suppresses *mediated* apoptosis of liver cells by the partial inhibition of signaling events including mitochondrial damage , cytochrome c release , and subsequent apoptosome formation and effector [caspase] activation . Positive_regulation CASP8 FAS 15860671 1439657 This was further supported by the finding that IFN treatment enhanced mediated [caspase-8] *activation* , one of the earliest signaling events downstream receptor activation . Positive_regulation CASP8 FAS 15863130 1401087 Binding of Fas ligand or agonistic anti-Fas antibody to the death receptor can *activate* a [caspase-cascade] resulting in apoptosis . Positive_regulation CASP8 FAS 15863130 1401092 Analysis of the Fas apoptotic pathway showed that treatment *induced* [caspase-8] activation and concomitantly Bid cleavage , caspase-9 and caspase-3 activation , PARP cleavage and apoptosis in HeLa and CaSki . Positive_regulation CASP8 FAS 16018969 1435072 In the present study , we investigated the *role* of signaling in [caspase 8] activation induced by fast neutrons irradiation in these cells . Positive_regulation CASP8 FAS 16112422 1448658 This study investigates the role of caspase-8 and DN-FADD , an inhibitor of *dependent* [caspase-8] activation , in gemcitabine induced apoptosis of Colo357 pancreatic cancer cells . Positive_regulation CASP8 FAS 16112422 1448660 DN-FADD , which surprisingly accumulated in nuclei of Colo357 cells , was unable to block [caspase-8] activation *mediated* by either gemcitabine or . Positive_regulation CASP8 FAS 16112422 1448662 These observations argue against a *role* of in gemcitabine induced [caspase-8] activation and reveal that the anti-apoptotic function of DN-FADD differs from caspase-8 inhibition in Colo357 cells . Positive_regulation CASP8 FAS 16120269 895979 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Positive_regulation CASP8 FAS 16246840 1489629 Stimulation of cell surface ( CD95 ) *results* in recruitment of cytoplasmic proteins and activation of [caspase-8] , which in turn activates downstream effector caspases leading to programmed cell death . Positive_regulation CASP8 FAS 16330535 1512014 ligation *increased* [caspase-3 and -8] activities during T cell activation , irrespective of cell fate . Positive_regulation CASP8 FAS 16384930 1547179 JAK2 mutated PV erythroblasts showed lower levels of induced [caspase] *activation* and incomplete caspase mediated cleavage of the erythroid transcription factor GATA-1 , which was entirely degraded in normal erythroblasts on CD95 stimulation . Positive_regulation CASP8 FAS 16527894 1574409 Simultaneously , mediated [caspase] *activation* precipitates differentiation . Positive_regulation CASP8 FAS 16538383 1555317 However using RNA interference and ectopic expression , we demonstrated that neither FADD nor were *necessary* for [caspase 8] activation and cell death . Positive_regulation CASP8 FAS 16646028 1557212 stimulation activated NF-kappaB and AP-1 , and this response *required* [caspase] activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation CASP8 FAS 16646083 1563152 Thus , A20 expression blocks OxLDL mediated apoptosis in murine RAW264.7 macrophages through disrupting *dependent* activation of [caspase-8] and the mitochondria pathway . Positive_regulation CASP8 FAS 16806159 1585954 Although it has been suggested that mediated signaling may *contribute* to the [caspase-8] activation induced by DNA damaging agents ; Positive_regulation CASP8 FAS 17088414 1644103 T3 attenuated *induced* cleavage of [caspase-8] and DNA fragmentation . Positive_regulation CASP8 FAS 17159907 1678921 Cysteine 199 mutants no longer form SDS-stable aggregates , and inhibition of palmitoylation reduces internalization of and *activation* of [caspase-8] . Positive_regulation CASP8 FAS 17222828 1689218 GSH dependent regulation of *mediated* [caspase-8] activation by acrolein . Positive_regulation CASP8 FAS 17245429 1690844 The nucleo-cytoplasmic translocation of FLASH requires *induced* [caspase] activation and is facilitated by the Crm1 dependent nuclear export pathway . Positive_regulation CASP8 FAS 17245429 1690848 Furthermore , we show that the adenoviral anti-apoptotic Bcl-2 family member E1B19K traps FLASH and procaspase-8 in a ternary complex at mitochondria , thereby blocking *induced* [caspase-8] activation . Positive_regulation CASP8 FAS 17304508 1718983 These results suggest the possible involvement of multiple signaling pathways from the MAPK to the subsequent mitochondria- and/or mediated [caspase] *activation* are potential requirements for PCA induced AGS apoptosis . Positive_regulation CASP8 FAS 17453339 1857950 We also found that inhibition of cFLIP ( L ) expression in T47D cells decreased mediated [caspase-8] *activation* and activation of effector caspases . Positive_regulation CASP8 FAS 17942717 1814064 The detailed analysis of this antagonism shows that FAIM ( L ) can bind to Fas receptor and prevent the activation of the initiator [caspase-8] *induced* by . Positive_regulation CASP8 FAS 18045865 1852403 It is concluded that a rapid [caspase 8] activation in *response* to signals to intracellularly stored CD95 , which becomes activated and targeted to the plasma membrane . Positive_regulation CASP8 FAS 18157585 1918902 TIMP-3 treatment induced the expression of and Fasl proteins , and the *activation* of [caspase-8] and caspase-3 . Positive_regulation CASP8 FAS 18386902 1907144 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , [caspase] activation , and *induction* . Positive_regulation CASP8 FAS 18593565 1953612 induced [caspase] *activation* leads to degradation of gp130 , thereby suppressing IL-6 induced phosphorylation of STAT3 ( Tyr ( 705 ) ) and of tyrosine phosphatase SHP2 ( Tyr ( 580 ) ) . Positive_regulation CASP8 FAS 18615109 1972357 We have shown that death of these precursors involved the *dependent* activation of [caspase-8] . Positive_regulation CASP8 FAS 18617900 1972385 In contrast , stimulation of T cells *resulted* in a much more profound activation of [caspase-8] that was exclusively cytosolic . Positive_regulation CASP8 FAS 18653623 1967111 IGF1 did not affect Fas expression or *activation* by of [caspase-8] , but inhibited the depolarization of the mitochondrial membrane . Positive_regulation CASP8 FAS 18761323 1985628 stimulation *induces* the binding of [caspase-8] to a death inducing signaling complex , leading to its autocatalytic cleavage and the formation of a caspase-8 homodimer , which is subsequently released into the cytosol where it further mediates the apoptotic signaling cascade . Positive_regulation CASP8 FAS 18948840 2041290 All *led* to a reduced DISC formation and diminished initiator [caspase] activity upon CD95-stimulation , whereas a marked heterogeneity in sensitivity to CD95 induced killing was found . Positive_regulation CASP8 FAS 19002587 1991273 In epithelial cells , *induced* hierarchic [caspase] activation is also linked with DEDD , a member of the DED family that binds to keratin (K) intermediate filaments ( IFs ) . Positive_regulation CASP8 FAS 19111607 2031769 However , recent studies have shown that can *induce* nonapoptotic [caspase independent cell death (CICD)] when caspase activity is inhibited . Positive_regulation CASP8 FAS 19413889 2240691 In addition , the changes that induced on Jurkat cell membrane organization caused clustering ( capping ) of the death receptor ( CD95 ) , [caspase-8] *activation* and initiation of the extrinsic apoptosis pathway , which finally resulted in programmed cell death . Positive_regulation CASP8 FAS 19521777 2098409 BEFV infection of BHK-21 cells results in the *dependent* activation of [caspase 8] and cleavage of Bid . Positive_regulation CASP8 FAS 19680267 2157908 CD95 is a death receptor whose stimulation by either the physiologic ligand or the agonistic antibodies *leads* to the formation of a multi-molecular complex termed DISC ( death inducing signaling complex ) and the subsequent induction of a [caspase-driven] apoptotic signal . Positive_regulation CASP8 FAS 19850829 2224729 Met12 inhibited *induced* [caspase 8] activation in 661W cells . Positive_regulation CASP8 FAS 19969555 2199629 Further studies demonstrated theaflavin *induced* upregulation through the activation of c-jun N-terminal kinase , Fas-FADD interaction in a Fas ligand independent manner , [caspase-8] activation and t-Bid formation . Positive_regulation CASP8 FAS 20406896 2246155 We also show that these stem cells derived from the human umbilical cord blood ( hUCB ) induce apoptosis-like cell death in the glioma cell line SNB19 via mediated [caspase-8] *activation* . Positive_regulation CASP8 FAS 20563667 2320300 Moreover , activation of caspase-3 , [caspase-8] and caspase-9 *induced* by stimulation of TNF-a , or TRAIL was significantly inhibited by the knockdown of DELE expression . Positive_regulation CASP8 FAS 20876774 2368754 Simultaneous downregulation of c-FLIP ( L ) and c-FLIP ( S ) as well as individual knockdown of either isoform by RNA interference significantly enhances TRAIL ( tumour necrosis factor related apoptosis inducing ligand ) - and *induced* [caspase] activation and caspase dependent apoptosis . Positive_regulation CASP8 FAS 21854868 2500971 Taken together , our data indicate that Akt/ERK mediated caspase-8 activation and *mediated* [caspase-8] activation mostly elucidate doxorubicin induced death in MCF-7 cells and MCF-7/Dox cells , respectively . Positive_regulation CASP8 FAS 21914378 2479403 NaF at the doses of 10 , 50 and 100 mg/L for 60 d and 90 d caused overexpression , *promoted* activity of caspase-3 and [caspase-8] , increased apoptosis rate in mandibular incisor cells . Positive_regulation CASP8 FAS 22108623 2517469 2-Hydroxy-3-methylanthraquinone from Hedyotis diffusa WILLD induces apoptosis via alteration of and *activation* of [caspase-8] in human leukemic THP-1 cells . Positive_regulation CASP8 FAS 22492309 2624602 Sulfuretin also activated the extrinsic apoptosis pathway , that is , it increased the expressions of and FasL , the *activation* of [caspase-8] , and the cleavage of Bid . Positive_regulation CASP8 FAS 22543586 2750633 Furthermore , loss of RAGE increased expression of the death receptor CD95 ( Fas , Apo-1 ) , dependent [caspase] *activation* and extrinsic apoptosis , whereas NF-kB-p65 nuclear translocation was diminished . Positive_regulation CASP8 FAS 22606292 2603705 HBV enhanced the mediated *activation* of caspase 6 , [caspase 8] and JNK without enhancing the activation of caspase 3 and hepatocellular apoptosis . Positive_regulation CASP8 FAS 22753932 2627265 caIKKß T cells showed increased Fas ligand expression and [caspase-8] activation , and blocking ligand interactions *enhanced* cell survival . Positive_regulation CASP8 FAS 23029562 2681063 Blocking the ERK pathway using a pharmacological inhibitor increased the susceptibility of 661W cells to induced [caspase] *activation* and apoptosis . Positive_regulation CASP8 FAS 23144495 2707415 signaling *activates* [caspase-8] in macrophages and dendritic cells , leading to the maturation of IL-1ß and IL-18 independently of inflammasomes or RIP3 . Positive_regulation CASP8 FAS 23152563 2707502 The proapoptotic effect of SOCS1 was manifested with increases in *induced* [caspase-8] activation , truncated Bid production , and mitochondrial dysfunctions . Positive_regulation CASP8 FAS 23285096 2711751 However , GTP induced upregulation through activation of c-jun-N-terminal kinase *resulted* in FADD phosphorylation , [caspase-8] activation and truncation of BID , leading to apoptosis in both LNCaPshV and LNCaPshp53 cells . Positive_regulation CASP8 FAS 23372841 2739211 Using rat oligodendroglial OLN-t40-AS cells we demonstrate that the cytotoxicity caused by coexpressing a-synuclein and p25a relies on stimulation of the death domain receptor and [caspase-8] *activation* . Positive_regulation CASP8 FAS 23422491 2744152 Binding of to its physiological receptor FAS , *induces* the activation of [caspase-8] , which triggers cell death . Positive_regulation CASP8 FAS 23530784 2762304 Various methods to inhibit apoptosis including the cell surface receptor pathway inhibitors , [caspase] *inhibitors* , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation CASP8 FAS 23941826 2861800 Moreover , it was found to induce apoptosis in MCF-7/ADR cells through the caspase dependent death-receptor pathway by enhancing levels of and FasL , and *activating* [caspase-8] and 3 . Positive_regulation CASP8 FAS 24442508 2918083 Beta cell upregulation by endogenously produced and exogenously applied hIAPP aggregates *promotes* [caspase-8] activation , resulting in beta cell apoptosis . Positive_regulation CASP8 FAS 24928990 2946827 Real-time detection of CTL function reveals distinct patterns of [caspase] activation *mediated* by versus granzyme B . Positive_regulation CASP8 FAS 24928990 2946855 Thus , we have used a novel , real-time assay to demonstrate the distinct pattern of [caspase] activation *induced* by granzyme B versus in human and murine CTLs . Positive_regulation CASP8 FAS 9452459 484117 Bcl-xL acts downstream of [caspase-8] *activation* by the death inducing signaling complex . Positive_regulation CASP8 FAS 9468507 486051 Stimulation of the or tumor necrosis factor receptor 1 (TNFR1) cell surface receptors *leads* to the activation of the death effector protease , [caspase-8] , and subsequent apoptosis . Positive_regulation CASP8 FAS 9468507 486059 Thus , at least in some cells , [caspase-8] signaling in *response* to or TNFR1 stimulation is regulated by a Bcl-xL-inhibitable step . Positive_regulation CASP8 FAS 9637489 513687 Here , we investigated whether the apoptosis occurring after TCR/CD9 stimulation is associated with a death pathway involving Fas stimulation and mediated [caspase] *activation* as observed in activation induced cell death ( AICD ) . Positive_regulation CASP8 FAS 9694885 524306 Our results demonstrate that whereas mediated activation of caspase 3 *requires* an upstream [caspase] activity that is zVAD-fmk-sensitive , the initial cleavage of caspase 3 during granule mediated cell death is insensitive to zVAD-fmk , suggesting that caspase 3 is cleaved directly by granzyme B in vivo . Positive_regulation CASP8 FAS 9701026 525271 Increased recruitment of cells undergoing apoptosis was associated with enhanced *induced* proteolytic cleavage of the most receptor-proximal cysteine protease [caspase-8] , subsequent cleavage and activation of the machinery protease caspase-3 , and cleavage of the caspase substrates DNA dependent protein kinase catalytic subunit , poly- ( ADP-ribose ) polymerase and lamin B1 . Positive_regulation CASP8 FAS 9837871 552438 This contrasts with the anti-apoptotic influence of Bcl-2 family proteins in the cell death pathway induced by Fas ligand or tumor necrosis factor (TNF) , in which Bcl-2 typically acts downstream of *mediated* activation of [caspase-8] . Positive_regulation CASP8 FUT4 17410536 1736343 induced *activation* of Fas associated death domain (FADD) and [caspase-8] was suppressed by RNA interference mediated inhibition of TNFR1 expression . Positive_regulation CASP8 IL1B 16153910 1455395 The kidney was analyzed for expression of tumor necrosis factor alpha , , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 mitogen activated protein kinase , caspase 3 , and [caspase 8] ( Western blot ) . Positive_regulation CASP8 IL1B 16305880 1485907 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , and interleukin-6 , and *activation* of caspase-1 , caspase-3 and [caspase-11] . Positive_regulation CASP8 IL1B 18054255 1918833 Western blot studies indicated that did not *induce* the time dependent activation of [caspase-8] , -7 and -3 as seen with TNF-alpha+Ro . Positive_regulation CASP8 MAOA 17883400 1830026 Two unrelated inhibitors *reduced* [caspase] activation . Positive_regulation CASP8 MAP2K6 15173003 1254026 The expression of constitutively activated 1 *enhanced* [caspase 8] recruitment and sensitized immortalized human embryonic kidney cells to TRAIL induced death . Positive_regulation CASP8 MAP2K6 16397410 1512996 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP8 MAP2K6 16672322 1583763 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* [caspase] activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only caspase activity . Positive_regulation CASP8 MAP2K6 21364665 2361146 dependent multiple [caspase] *activation* by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP8 MMP28 13679861 1140635 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP8 MMP28 19259823 2072636 Significant enhancement of Fas externalization , loss of mitochondrial , and *activation* of caspase-3 and [caspase-8] were observed after the combined treatment . Positive_regulation CASP8 MMP28 20545600 2308326 MG132 inhibited the growth of As4.1 cells and induced cell death , accompanied by the loss of mitochondrial membrane potential ( ) and *activation* of [caspase-3 and -8] . Positive_regulation CASP8 MMP7 13679861 1140650 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP8 MMP7 19259823 2072651 Significant enhancement of Fas externalization , loss of mitochondrial , and *activation* of caspase-3 and [caspase-8] were observed after the combined treatment . Positive_regulation CASP8 MMP7 20545600 2308341 MG132 inhibited the growth of As4.1 cells and induced cell death , accompanied by the loss of mitochondrial membrane potential ( ) and *activation* of [caspase-3 and -8] . Positive_regulation CASP8 RGS16 15115810 1241635 Manipulation of endogenous GRK2 activity through introduction of either wild-type or catalytically inactive GRK2 ( ( K220R ) GRK2 ) almost completely inhibited agonist stimulated IP3 production , implying a phosphorylation independent regulation of M1 [mACh] receptor signaling , most probably *mediated* by a GRK2 N-terminal RGS-like ( ) domain interaction with GTP bound Galpha ( q/11 ) . Positive_regulation CASP8 RGS2 15115810 1241636 Manipulation of endogenous GRK2 activity through introduction of either wild-type or catalytically inactive GRK2 ( ( K220R ) GRK2 ) almost completely inhibited agonist stimulated IP3 production , implying a phosphorylation independent regulation of M1 [mACh] receptor signaling , most probably *mediated* by a GRK2 N-terminal RGS-like ( ) domain interaction with GTP bound Galpha ( q/11 ) . Positive_regulation CASP8 RNASE1 15620724 1357852 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and *induced* [caspase] activation in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP8 RNASE1 15620724 1358086 We find that RC-RNase and *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP8 RNASE1 24271942 2904517 Apoptosis occurred through the caspase-3 pathway following *activation* of [caspase-8] by . Positive_regulation CASP8 RNASE7 15620724 1357860 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and *induced* [caspase] activation in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP8 RNASE7 15620724 1358094 We find that RC-RNase and *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP8 RNASE7 24271942 2904525 Apoptosis occurred through the caspase-3 pathway following *activation* of [caspase-8] by . Positive_regulation CASP8 SPHK1 11238741 791092 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Positive_regulation CASP8 TNF 10358077 618751 In addition , IFN-gamma/TNF-alpha and *stimulate* activation of [caspase-8] and caspase-3 , which IL-13 pretreatment was able to partially inhibit and delay . Positive_regulation CASP8 TNF 10425195 632762 *induces* [caspase] activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation CASP8 TNF 10442631 635703 Based on cleavage of the FLICE substrate PARP , this inhibitory effect was paralleled by a threefold decline in [FLICE] activation in *response* to . Positive_regulation CASP8 TNF 10586080 571807 Silymarin also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated induced cytotoxicity and [caspase] *activation* . Positive_regulation CASP8 TNF 10593992 572965 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Positive_regulation CASP8 TNF 10599977 573795 These results suggest that can *cause* apoptosis in pancreatic beta cells through TNFR1 linked apoptotic factors , TRADD , FADD , and [FLICE] , and TNF induced ceramide production may be involved in the pathways . Positive_regulation CASP8 TNF 10720949 677034 Overexpression of I kappa B delta N augmented *induced* caspase-3 and [caspase-8] activity , but did not affect Bcl-2 or Bax protein expression . Positive_regulation CASP8 TNF 10764744 698790 The activities of [caspase-3 and -8] were *increased* by , with the highest activities found in mC5 cells . Positive_regulation CASP8 TNF 10764744 698800 Addition of H ( 2 ) O ( 2 ) prevented *induced* apoptosis and [caspase] activation , an effect prevented by simultaneous addition of catalase . Positive_regulation CASP8 TNF 10792026 691023 In combination with TNF-alpha , however , ceramide potentiated , whereas NO inhibited , *induced* TRADD recruitment and [caspase 8] activity . Positive_regulation CASP8 TNF 10820260 694394 *induced* cytotoxicity , [caspase] activation , and lipid peroxidation were also abolished by vesnarinone . Positive_regulation CASP8 TNF 10843709 700180 Resveratrol also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated induced cytotoxicity and [caspase] *activation* . Positive_regulation CASP8 TNF 11095643 755307 In mechanistic terms , bFGF synergistically increased *induced* mitochondrial permeability transition , the release of cytochrome c from mitochondria to the cytosol , and upregulation of the proapoptotic protein Bak and significantly enhanced activation of [caspase-8] protease activity . Positive_regulation CASP8 TNF 11102441 810396 CsA blocked the *induced* release of [pro-caspase 8] but not cytochrome c . Positive_regulation CASP8 TNF 11112424 757614 *caused* a rapid activation of [caspase-8] and -7 in cells transfected with a vector . Positive_regulation CASP8 TNF 11112424 757620 Overexpression of PKC eta delayed the *activation* of [caspase-8] and -7 by both and the combination of BIM and TNF . Positive_regulation CASP8 TNF 11228746 581011 induced *activation* of [caspase] activity was blocked by all three types of quenchers . Positive_regulation CASP8 TNF 11346652 827751 Intriguingly , unlike the caspase-8 inhibitor cellular FADD-like interleukin-1 beta converting enzyme-inhibitory protein ( c-FLIP ) , NDED suppressed TNF mediated apoptosis by inhibiting *induced* [caspase-8] enzymatic activity but not the processing of caspase-8 . Positive_regulation CASP8 TNF 11350795 814708 Reductions in MLC phosphorylation by the inhibition of either MLC kinase ( ML-7 , cholera toxin ) or Rho kinase ( Y-27632 ) dramatically attenuated *induced* stress fiber formation , indexes of apoptosis , and [caspase-8] activity but not TNF-alpha induced barrier dysfunction . Positive_regulation CASP8 TNF 11439335 833183 A TNFR1-antagonistic mAb or a TRAIL decoy receptor inhibited the activation of [caspase-8] and the subsequent apoptosis *induced* by or TRAIL , respectively , in the cells . Positive_regulation CASP8 TNF 11827262 909403 Additionally , we found that the inhibition of NFkappaB by Adv-SR-IkappaBalpha enhanced mediated [caspase-8] and -3 *activation* . Positive_regulation CASP8 TNF 11835405 911418 Additionally , *induced* caspase-3 and [caspase-8] activation and TNF induced PARP cleavage were unaffected by the presence or absence of STAT1 . Positive_regulation CASP8 TNF 11847111 912599 mediated [caspase] *activation* and block of differentiation are dependent upon the expression of PW1 , but occur independently of NFkappaB activation . Positive_regulation CASP8 TNF 11877450 937176 Also , treatment of cells with kamebakaurin prevented the tumor necrosis factor-alpha (TNF-alpha) induced expression of antiapoptotic NF-kappaB target genes encoding c-IAP1 ( hiap-2 ) and c-IAP2 ( hiap-1 ) , members of the inhibitor of apoptosis family , and Bfl-1/A1 , a prosurvival Bcl-2 homologue , and augmented the *induced* [caspase 8] activity , thereby resulting in sensitizing MCF-7 cells to TNF-alpha induced apoptosis . Positive_regulation CASP8 TNF 12031968 947872 Together , our data demonstrate that overexpression of cFLIP protects mouse beta-cells against *induced* [caspase-8] activation and apoptosis and is correlated with enhanced NF-kappaB transcriptional activity , suggesting that cFLIP may have an impact on the outcome of death receptor triggered responses by directing the intracellular signals from beta-cell death to beta-cell survival . Positive_regulation CASP8 TNF 12036088 949072 *promotes* [caspase] activation and apoptosis in human fetal membranes . Positive_regulation CASP8 TNF 12077131 976075 did not *activate* [caspase-8] but activated caspase-3 , -10 , and -12 . Positive_regulation CASP8 TNF 12080044 976127 We also showed that stable overexpression of A20 inhibits apoptosis and [caspase] activation *induced* by . Positive_regulation CASP8 TNF 12115505 964132 Therefore , Kupffer cells execute their anti-tumor effect via increasing the production of NO , and IFNgamma and these cytotoxic molecules inhibit the growth of tumor by damaging cellular DNA and *inducing* apoptosis that was featured by downregulation of Bcl-2 but upregulation of [caspase-8] . Positive_regulation CASP8 TNF 12368201 995355 In addition , the *induced* [caspase-8] activity in SMP30-/- hepatocytes was twofold greater than that in SMP30+/+ hepatocytes . Positive_regulation CASP8 TNF 12374208 996561 *activated* [caspase 8] and caspase 3 in PC12 cells , leading to cell death by apoptosis ( DNA fragmentation ) . Positive_regulation CASP8 TNF 12388814 1000341 Activation of [caspase-8] *induced* either by or by Fas ligand expression was prevented by the R1 protein . Positive_regulation CASP8 TNF 12431778 1015389 Our results demonstrate that TGF-beta1 can decrease TNF-alpha induced apoptosis in murine osteoblasts at least in part by attenuating *induced* [caspase] gene expression . Positive_regulation CASP8 TNF 12517920 1071015 mediated TNFR1-FADD association and [caspase 8] *activation* were not inhibited by IBOP co-stimulation , however , resulting in a 2.6-fold increase in endothelial cell apoptosis . Positive_regulation CASP8 TNF 12552004 1051451 E1A promoted *mediated* activation of [caspase-8] , suggesting that sensitivity was occurring at the level of the death inducing signaling complex . Positive_regulation CASP8 TNF 12663669 1092708 In the presence of cycloheximide , or interleukin-1 *initiates* [caspase] activation , loss of mitochondrial membrane potential ( DeltaPsi ) , DNA degradation , and nuclear condensation and fragmentation characteristic of apoptotic cell death in human vascular endothelial cells ( EC ) . Positive_regulation CASP8 TNF 12763364 1093896 The latter and mediated [caspase] *activation* was attenuated by prostaglandin E ( 2 ) . Positive_regulation CASP8 TNF 12800192 1098920 The antioxidants N-acetylcysteine , reduced glutathione , lipoic acid and ascorbic acid markedly reduced the enhancing effect of the hormone on *induced* [caspase] activation . Positive_regulation CASP8 TNF 12800192 1098933 The effect of calcitriol on DeltaPsi was mimicked by rotenone , which increased both the drop in DeltaPsi and [caspase] activation *induced* by . Positive_regulation CASP8 TNF 12804035 1101398 In normal cells , *activates* [caspase 8] in both mitochondrion dependent and mitochondrion independent apoptotic pathways . Positive_regulation CASP8 TNF 12828936 1105043 Although caspase-8 is known to be involved in death-receptor dependent apoptosis , measurable [caspase-8] activity or even RGC death could be *induced* by neither nor Fas ligand injections into unlesioned eyes . Positive_regulation CASP8 TNF 12869656 1112224 Both C2-ceramide and + CHX *increased* [caspase 8-] and 3-like activities in cytosolic extracts ; Positive_regulation CASP8 TNF 12959751 1138350 Virally encoded genes inhibit the *activation* of [caspase-8] by the receptor and Fas ; Positive_regulation CASP8 TNF 14532003 1152078 ( TNFalpha ) receptor signaling can simultaneously *activate* [caspase 8] , the transcription factor , NF-kappaB and the kinase , JNK . Positive_regulation CASP8 TNF 14580328 1156832 In the October 3 issue of Cell , Deng et al. ( 2003 ) report that a JNK dependent mitochondrial signal , the release of Smac/DIABLO , is required for *induced* [caspase 8] activation and apoptosis . Positive_regulation CASP8 TNF 14696112 1195289 In addition , 2-methoxyestradiol treatment caused upregulation of death receptor ligands FasL and and *induced* [caspase-8] activation . Positive_regulation CASP8 TNF 15033766 1184114 The antioxidants N-acetylcysteine , glutathione , lipoic acid , and ascorbic acid markedly reduced the effect of the hormone on induced [caspase] *activation* , attesting to the involvement of reactive oxygen species ( ROS ) in the cross-talk between the hormone and the cytokine . Positive_regulation CASP8 TNF 15173123 1259157 Furthermore , in Jak-deficient cell lines , DNA fragmentation and [caspase-8] *activation* by are suppressed , indicating that Jaks participate in TNF-alpha induced apoptosis signaling . Positive_regulation CASP8 TNF 15283855 1277827 In the *presence* of or endotoxin ( LPS ) , blockade of CD18 ( beta2 chain ) with mAb markedly increased [caspase] activation in PMN on fibrinogen . Positive_regulation CASP8 TNF 15389560 1304791 Fluorometric studies demonstrated that in vivo predominantly *increased* [caspase-8] and -3 activity and by use of specific inhibitors , the activation of caspase-3 was shown to be initiated by caspase-8 with only a minor contribution from caspase-9 . Positive_regulation CASP8 TNF 15452110 1341979 These mutant cells exhibited a defect in *induced* [caspase] activation , Bid cleavage , and release of cytochrome c . Positive_regulation CASP8 TNF 15492857 1321707 As the molecular mechanism involved , we showed Delta-1 stimulation partially suppressed the sequential activation of [caspase-8] , caspase-3 , and , PARP *induced* by . Positive_regulation CASP8 TNF 15663790 1369559 In the initiation phase of pulmonary oxygen toxicity , an increase of and its receptor TNFR1 *leads* to the activation of [caspase 8] and 3 in TIIcells . Positive_regulation CASP8 TNF 15727562 1416779 In time course analyses , cleavage and activation of [caspase 8] in *response* to were not affected by MitoVit E , whereas the activation of caspase 3 was significantly increased . Positive_regulation CASP8 TNF 15791480 1386603 As mitochondria related activation of this caspase cascade , through e.g . APAF-1 , could not be proven in dystrophin-deficient muscle , this study searches for other prospective candidates that may directly trigger apoptotic cell degradation by mitochondria independent pathways involving the interaction of and TRAIL with death receptors and subsequent *activation* of [caspase-8] . Positive_regulation CASP8 TNF 16263807 1539297 *initiated* [caspase-8] activity and cleavage of pro-caspase-3 at the convergence point of the two pathways . Positive_regulation CASP8 TNF 16371840 1505252 [Caspase-8] , which is *activated* by the induction of , leads to activation of caspase-3 , which activates apoptotic nucleases . Positive_regulation CASP8 TNF 16492401 1567745 induced a gradual *increase* in [caspase-1 and -8] mRNA levels that was not seen with IL-1beta . Positive_regulation CASP8 TNF 16532377 1555290 Inhibition of the p38 and/or the JNK death pathways reduced [caspase] activation *induced* by oxidative stress , hyperosmotic shock and . Positive_regulation CASP8 TNF 16611896 1545346 A decrease in endogenous c-FLIP by specific small interfering RNA induced *mediated* apoptotic cell death and [caspase-8] activation . Positive_regulation CASP8 TNF 16631528 1552356 We report that DDC strongly inhibits [caspase] activation , loss of DeltaPsim , and cell death *induced* by or etoposide . Positive_regulation CASP8 TNF 16645635 1671990 Importantly , sst2 sensitized NIH3T3 cells to TNFalpha induced apoptosis by ( 1 ) upregulating TNFalpha receptor protein expression , and sensitizing to *induced* [caspase-8] activation ; Positive_regulation CASP8 TNF 16715133 1638319 Taken together , these data suggest that upregulation of TMS1/ASC by and subsequent *activation* of [caspase-8] could function to amplify the apoptotic signal induced by death receptors in some cell types , including breast epithelial cells . Positive_regulation CASP8 TNF 16730193 1570518 After 24-h exposure , *increased* [caspase-8] activities , mitochondrial cytochrome C (Cyt C) release to the cytosol , accompanied by loss of mitochondrial transmembrane potential ( delta psi ( m ) ) . Positive_regulation CASP8 TNF 17047073 1635894 Importantly , down-regulation of TRAIL by small interfering RNA silencing decreased mediated Adriamycin induced [caspase] *activation* and apoptosis , and thus enhanced breast cancer cell resistance to Adriamycin . Positive_regulation CASP8 TNF 17051336 1649463 and IFN-gamma induced apoptosis in HSG cells and *resulted* in the activation of [caspase 8] and the `` death receptor '' pathway . Positive_regulation CASP8 TNF 17088414 1644102 T3 attenuated *induced* cleavage of [caspase-8] and DNA fragmentation . Positive_regulation CASP8 TNF 17125837 1686485 ATD5 could also reduce the TNF-alpha mediated cytotoxicity and inhibit mediated [caspase] *activation* on L929 cells in a dose dependent manner . Positive_regulation CASP8 TNF 17463158 1731678 Furthermore , induced *activations* of caspase 3 and [caspase 8] in the liver were significantly inhibited by zinc pretreatment . Positive_regulation CASP8 TNF 17599041 1848499 We have recently shown that *induces* [caspase dependent and -independent] JNK activation and ROS accumulation in cellular FLICE-inhibitory protein ( c-Flip ) ( -/- ) murine embryonic fibroblasts ( MEFs ) . Positive_regulation CASP8 TNF 17636167 1770715 Although did not *cause* a measurable increase in [caspase-8] activity , there was a tendency ( P = 0.07 ) for treatment of embryos with z-IETD-fmk , an inhibitor of caspase-8 , to partly reduce the magnitude of the increase in TUNEL positive cells caused by TNF-alpha . Positive_regulation CASP8 TNF 17686781 1800365 *activates* [caspase-8] to cleave effector caspases or Bid , resulting in type-1 or type-2 apoptosis , respectively . Positive_regulation CASP8 TNF 18023359 1832136 Mitochondrial apoptotic inducer bax , and the suppressor bcl-2 were evaluated using western blotting at 48 h. Results indicated that *increased* [caspase] activities and resulted in a significant ( p = 0.001 ) increase in bax/bcl-2 ratio . Positive_regulation CASP8 TNF 18054255 1918875 As quantified by flow cytometry , *induced* a higher level of [caspase-3 and -8] activation than that seen with IL-1beta+Ro. Pre-incubation for 2h with caspase inhibitors for caspase-3 , -7 , -8 and pan-caspase significantly decreased the hypodiploid DNA peak induced by treatment with TNF-alpha+Ro at 24 h. Indomethacin increased the cell death induced by IL-1beta+Ro ; Positive_regulation CASP8 TNF 18289527 1878523 Ectodomain shedding of TNF receptor 1 induced by protein synthesis inhibitors regulates *mediated* activation of NF-kappaB and [caspase-8] . Positive_regulation CASP8 TNF 18289527 1878526 Nevertheless , we have surprisingly found that CHX , as well as its structural analogue acetoxycycloheximide ( Ac-CHX ) , prevents mediated *activation* of NF-kappaB and [caspase-8] in human lung carcinoma A549 cells . Positive_regulation CASP8 TNF 18289527 1878529 CHX and Ac-CHX profoundly decreased constitutive and inducible expression of c-FLIP , whereas these compounds potentiated *induced* [caspase-8] activation only when metalloprotease inhibitors were present . Positive_regulation CASP8 TNF 18289527 1878530 Thus , our results indicate that ectodomain shedding of TNF-R1 induced by protein synthesis inhibitors regulates *mediated* activation of NF-kappaB and [caspase-8] . Positive_regulation CASP8 TNF 18343380 1905268 Unexpectedly , we observed that *activates* [caspase-8] independently of NF-kappaB inactivation , causing Bid cleavage and mitochondrial Bax oligomerization . Positive_regulation CASP8 TNF 18467439 1938883 However , XIAP small interfering RNA restored *induced* [caspase] signaling and apoptosis in Hec-1A cells ; Positive_regulation CASP8 TNF 18638380 1947611 EPA protective activity was associated with blocking cell death pathways as EPA completely attenuated *mediated* increases in [caspase-8] activity ( p < 0.05 ) and cellular necrosis ( p < 0.05 ) back to their respective control levels . Positive_regulation CASP8 TNF 19152111 2038065 Previously , employing in vitro differentiated human macrophages , we showed that following the inhibition of NF-kappaB , induced [caspase-8] *activation* contributes to DNA fragmentation but is not necessary for the loss of the inner mitochondrial transmembrane potential ( DeltaPsim ) or cell death . Positive_regulation CASP8 TNF 19345705 2094388 Finally , reconstitution of PPT1 activity in mutant cells was accompanied by resensitization to induced [caspase] *activation* and toxicity . Positive_regulation CASP8 TNF 19440308 2078414 Muscle regeneration is , at least in part , regulated by caspase activation , and AVP abrogated dependent [caspase] *activation* . Positive_regulation CASP8 TNF 19524691 2121000 The increased levels *led* to activation of [caspase-8] by an autocrine effect via the TNF receptor expressed by the P388D1 macrophages . Positive_regulation CASP8 TNF 19555759 2117077 In this paradigm , apoptosis depends on induced *activation* of [caspase-8] and -3 without affecting the activation of caspase-9 . Positive_regulation CASP8 TNF 19555759 2117081 By using knock-out mice for TNF-alpha receptor 1 , we show that the *activation* of both [caspase-3 and -8] by is mediated by TNF-alpha receptor 1 . Positive_regulation CASP8 TNF 19813266 2195929 Genistein triggered the receptor mediated apoptotic pathway through upregulation of , FasL , TRADD , and FADD and *activation* of [caspase-8] . Positive_regulation CASP8 TNF 20200974 2299817 Silencing FOXO1 using siRNA in vitro significantly reduced *induced* apoptosis and [caspase] activity in differentiated chondrocytes . Positive_regulation CASP8 TNF 20236182 2237964 DEC2 over-expression caused by the transfection of an expression vector reduced the amounts of cleaved PARP and [caspase-8] *induced* by treatment , whereas DEC1 over-expression increased it . Positive_regulation CASP8 TNF 20563667 2320299 Moreover , activation of caspase-3 , [caspase-8] and caspase-9 *induced* by stimulation of , anti-Fas or TRAIL was significantly inhibited by the knockdown of DELE expression . Positive_regulation CASP8 TNF 20564232 2290298 Immunoprecipitation studies revealed associations of NM IIB with clathrin , FADD , and [caspase 8] in *response* to suggesting a role for NM IIB in TNFR1 endocytosis and the formation of the death inducing signaling complex (DISC) . Positive_regulation CASP8 TNF 20674553 2317179 Moreover , antofine potentiated *induced* apoptosis , which was demonstrated by the increase of Annexin V-positive cell population and of the cleavage of poly ( ADP-ribose ) polymerase ( PARP ) and [caspase-8] . Positive_regulation CASP8 TNF 20951126 2364937 The damnacanthal mediated expression of DR5/TRAIL and *results* in [caspase 8] activation , leading to Bid cleavage . Positive_regulation CASP8 TNF 21244577 2402771 In addition , wogonin suppressed the expression of the antiapoptotic factor c-FLIP , which is accompanied with potentiation of *induced* [caspase 8] activation that initiates apoptosis . Positive_regulation CASP8 TNF 21269505 2392751 is also *required* for appropriate regulation of [caspase] genes . Positive_regulation CASP8 TNF 21620750 2454481 Sam68 is also found as a part of the *induced* cytoplasmic [caspase-8-FADD] complex . Positive_regulation CASP8 TNF 21788490 2467521 *induced* [caspase-8] activation leads to leaky RyR2 channels that contribute to myocardial remodeling after I/R . Positive_regulation CASP8 TNF 21893119 2506490 Conversely , *activation* of [caspase] by exogenous required IL-13 , TWEAK , and Fn14 . Positive_regulation CASP8 TNF 22241962 2519623 In support of this notion , inhibition of by the TNFa blocking antibody Enbrel *reduces* BV6- and gemcitabine induced activation of [caspase 8] and 3 , loss of mitochondrial membrane potential , and apoptosis . Positive_regulation CASP8 TNF 22567171 2596905 Myocardial rate pressure product ( RPP , LVDP*heart rate ) was markedly decreased in male hearts compared to females in exposure to TNF , which was associated with higher levels of *induced* [caspase-8] and caspase-3 . Positive_regulation CASP8 TNF 22869322 2682527 In differentiating human omental adipocytes , incubation with acylated and desacyl ghrelin reduced induced *activation* of [caspase-8] and caspase-3 , and cell death . Positive_regulation CASP8 TNF 23151904 2723060 CF31 inhibition of activation of AKT also *results* in TNF-a dependent activation of [caspase-8] and apoptosis . Positive_regulation CASP8 TNF 23688976 2785591 a-Toxin induced apoptosis of HUV-EC-C cells in a dose- and time dependent manner and caused significantly enhanced expression of and the *activation* of both caspase-3 and [caspase-8] . Positive_regulation CASP8 TNF 23759588 2812172 Subsequent synthesis of TNF-a in the cells under the action of binase triggers extrinsic apoptotic pathway through the binding of with cell-death receptors and *activation* of [caspase 8] . Positive_regulation CASP8 TNF 24684347 2935146 Smac-mimetic 1-induced loss of cIAPs correlated with inhibition of mediated NF-?B activation , [caspase] *activation* , and tumor cell killing . Positive_regulation CASP8 TNF 9531309 496834 Furthermore , only murine but not IL-1alphabeta *increased* [caspase] activity and apoptosis . Positive_regulation CASP8 TNF 9885230 584460 induced [caspase] *activation* was accompanied by a decrease in the ability of neutrophils to release superoxide anion . Positive_regulation CASP8 TNF 9885230 584486 Granulocyte-macrophage colony stimulating factor inhibited induced [caspase] *activation* and apoptosis , while reversing the diminution in superoxide release . Positive_regulation CASP8 TNFSF10 10894161 711500 induced homomeric and heteromeric complexes of DR4 and DR5 and *stimulated* recruitment of FADD and caspase-8 and [caspase-8] activation in nontransfected cells . Positive_regulation CASP8 TNFSF10 11004677 734967 The apoptotic programme in the sensitive ESFT VH-64 cell line revealed induced *activation* of [FLICE/MACH1] ( caspase-8 ) and CPP32/Yama/apopain ( caspase-3 ) and processing of the prototype caspase substrate poly ( ADP-ribose ) polymerase . Positive_regulation CASP8 TNFSF10 11004677 734968 However , zIETDfmk , but not zDEVDfmk , reduced TRAIL mediated DeltaPsi ( m ) dissipation , indicating that *causes* mitochondrial dysfunction through [caspase-8] acting upstream of mitochondria . Positive_regulation CASP8 TNFSF10 11221844 787391 In *response* to , [caspase-8] , an initiator caspase in death receptor mediated apoptosis , was activated within 1 h in association with Bid cleavage , cytochrome c release , caspase-3 activation , and DNA fragmentation factor 45 cleavage . Positive_regulation CASP8 TNFSF10 11245478 793116 Together , these data indicate that chemotherapeutic drugs sensitize colon tumor cells to mediated [caspase-8] *activation* and apoptosis . Positive_regulation CASP8 TNFSF10 11279540 764693 In addition , expression of Toso , a cell surface apoptosis regulator , seemed to block *activation* of [caspase-8] by via enhanced expression of FLIPL in granulocytic differentiated cells . Positive_regulation CASP8 TNFSF10 11439335 833184 A TNFR1-antagonistic mAb or a TRAIL decoy receptor inhibited the activation of [caspase-8] and the subsequent apoptosis *induced* by TNFalpha or , respectively , in the cells . Positive_regulation CASP8 TNFSF10 11677236 896126 Combining and interferon in vitro , synergistically *induced* apoptosis and [caspase] activation in breast cancer cells . Positive_regulation CASP8 TNFSF10 11750844 898148 Upon binding of tumour necrosis factor (TNF) related apoptosis inducing ligand ( TRAIL ) , the agonistic receptors DR4 and DR5 *activate* [caspase-8] leading to apoptosis . Positive_regulation CASP8 TNFSF10 11782443 900529 Bax deficiency has no effect on *induced* [caspase-8] activation and subsequent cleavage of Bid ; however , it results in an incomplete caspase-3 processing because of inhibition by XIAP . Positive_regulation CASP8 TNFSF10 11936954 961569 IFN-gamma promoted *mediated* activation of [caspase-8] , Bcl-2 interacting domain death agonist ( Bid ) degradation , Bcl-2 associated X protein (Bax) translocation to mitochondria , cytochrome c release to the cytosol and activation of caspase-9 in these cell lines . Positive_regulation CASP8 TNFSF10 11948412 930153 Bcl-2 overexpression reduced *induced* cleavage of [caspase-8] and Bid indicating that caspase-8 was activated upstream and also downstream of mitochondria in a feedback amplification loop . Positive_regulation CASP8 TNFSF10 11948412 930157 In contrast , in SKW lymphoblastoid cells , *induced* activation of [caspase-8] directly translated into full activation of caspases , cleavage of XIAP , DFF45 or PARP and apoptosis independent of Bcl-2 overexpression , although Bcl-2 similarly inhibited loss of mitochondrial membrane potential and the release of cytochrome c , AIF and Smac from mitochondria in all cell types . Positive_regulation CASP8 TNFSF10 11992615 938772 LNCaP is resistant to TRAIL but transiently *induces* DEVDase activity and activation of [caspase-8] ; Positive_regulation CASP8 TNFSF10 12097388 961384 *activated* [caspase-8] and caspase-3 , but subsequent apoptotic events such as poly ( ADP-ribose ) polymerase cleavage and DNA fragmentation were not observed . Positive_regulation CASP8 TNFSF10 12407100 1036218 [Caspase 8] and 10 *activation* , bid cleavage , cytosolic cytochrome c , and caspase 3 activation by were all increased by the bile acid glycochenodeoxycholate ( GCDCA ) . Positive_regulation CASP8 TNFSF10 12520089 1028119 In accordance with the presumed function of FLIP as an inhibitor of death receptor induced caspase-8 activation , down-regulation of FLIP by siRNAs enhanced *induced* [caspase-8] activation . Positive_regulation CASP8 TNFSF10 12592338 1060366 *activated* [caspase-8] but not caspase-9 or -10 in HL60 cells . Positive_regulation CASP8 TNFSF10 12642868 1069465 Moreover , IFN-alpha pretreatment clearly augmented mediated [caspase-8] *activation* in HuH-7 cells . Positive_regulation CASP8 TNFSF10 12815069 1103422 In addition , overexpression of cleavage-site mutant c-IAP1 makes cells more resistant to induced [caspase] *activation* . Positive_regulation CASP8 TNFSF10 12919886 1130908 CDDP down-regulated c-FLIP , tending to lower the activation threshold required for *induced* [caspase-8] activation . Positive_regulation CASP8 TNFSF10 12919886 1130909 The CDDP pretreated cells indeed demonstrated more increased mediated [caspase-8] *activation* , loss of mitochondrial membrane potential ( DeltaPsi ( m ) ) , and apoptosis than untreated cells . Positive_regulation CASP8 TNFSF10 14644092 1188262 Furthermore , the enhancement extended to *induced* [caspase-activation] . Positive_regulation CASP8 TNFSF10 14690854 1194687 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , Fas , and receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP8 TNFSF10 15033719 1184084 CHX or DOX was shown to enhance *induced* [caspase-8] activation and loss of mitochondrial transmembrane potential . Positive_regulation CASP8 TNFSF10 15173003 1254020 Ras transformation enhanced *induced* activation of [caspase 8] by increasing its recruitment to TRAIL receptors . Positive_regulation CASP8 TNFSF10 15197350 1347066 In this study , we show that TPCK inhibits *induced* [caspase] activity but potentiates wortmannin dependent caspase activity in prostatic carcinoma cell lines . Positive_regulation CASP8 TNFSF10 15369772 1297217 at 500 ng/ml *induced* significant DNA fragmentation , activation of [caspase-8] and 3 , the processing of a proapoptotic BID , and mitochondrial release of cytochrome c in HL-60/Vect cells , whereas no such events were observed in the HL-60/FAK cells . Positive_regulation CASP8 TNFSF10 15475369 1319207 Instead , in the presence of DcR3 , engagement *resulted* in an increased activation of [caspase-8] , an elevated cleavage of Bid , and enhanced release of Smac and cytochrome c from mitochondria to cytosol compared with TRAIL alone . Positive_regulation CASP8 TNFSF10 15531922 1360368 After having analysed the dose response for *induced* activation of [caspase-8] , -9 , -3 , breakdown of the mitochondrial membrane potential , and changes in the apoptotic morphology in cells expressing different Bcl-2 levels , we conclude that overexpression of Bcl-2 mediates a partial resistance towards lower doses of TRAIL that can be overcome when higher doses of TRAIL are applied . Positive_regulation CASP8 TNFSF10 15547726 1338355 In five of the neuroblastoma cell lines ( SHEP-1 , SK-N-AS , SK-N-FI , SH-SY-5Y and Kelly ) , IFN-gamma promoted *mediated* cleavage of [caspase-8] , initiating a caspase cascade involving caspase-7 and PARP followed by apoptosis . Positive_regulation CASP8 TNFSF10 15558024 1361133 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both promoted by amiloride . Positive_regulation CASP8 TNFSF10 15569667 1368293 Here we demonstrate that human breast cancer cells , but not normal mammary epithelial cells , are dramatically sensitized to induced apoptosis and [caspase] *activation* by peroxisome proliferator activated receptor gamma ( PPARgamma ) agonists of the thiazolidinedione ( TZD ) class . Positive_regulation CASP8 TNFSF10 15607733 1357000 Amiloride enhanced induced apoptosis and *activation* of [caspase-3 and -8] in both cells . Positive_regulation CASP8 TNFSF10 15623604 1349126 Bcl-2 overexpression attenuated *induced* cleavage of [caspase-8] , indicating its activation upstream and downstream of mitochondria , as well as cleavage of Bid and caspase-3 . Positive_regulation CASP8 TNFSF10 15791480 1386604 As mitochondria related activation of this caspase cascade , through e.g . APAF-1 , could not be proven in dystrophin-deficient muscle , this study searches for other prospective candidates that may directly trigger apoptotic cell degradation by mitochondria independent pathways involving the interaction of tumour necrosis factor-alpha (TNF-alpha) and with death receptors and subsequent *activation* of [caspase-8] . Positive_regulation CASP8 TNFSF10 15792357 1386645 Western blot analysis showed that the hypoxia augmented induced PARP cleavage as well as the *activation* of [caspase-8] and caspase-3 , but not caspase-9 . Positive_regulation CASP8 TNFSF10 16024639 1435292 Tunicamycin and cooperatively *activated* [caspase-8] , -10 , -9 , and -3 and Bid cleavage and this activation was also blocked in the presence of the DR5/Fc chimera . Positive_regulation CASP8 TNFSF10 16103097 1444528 Generation of ROS by CCCP was responsible for *induced* Bax and [caspase] activation because scavenging ROS completely abrogated apical caspase-8 activation and further downstream events leading to cell death . Positive_regulation CASP8 TNFSF10 16112027 1448541 FADD-DN inhibited [caspase-8] activation *induced* by in the transfectants of CM and NES2Y cells . Positive_regulation CASP8 TNFSF10 16225956 1508213 However , co-stimulation with IFNalpha doubled *mediated* apoptosis and enzymatic [caspase-8] activity . Positive_regulation CASP8 TNFSF10 16619517 1551265 Moreover , *induction* of [caspase-8] activation by or TRAIL plus CDDP/DXR was substantially prevented by dnJNK . Positive_regulation CASP8 TNFSF10 16715133 1638309 We further show that whereas TMS1/ASC is not required for TNFalpha or *induced* activation of NF-kappaB or [caspase-8] , it can promote caspase-8 activation independently of death receptor-ligand interactions . Positive_regulation CASP8 TNFSF10 17031493 1674356 ligation recruits and *activates* [pro-caspase-8] , which in turn activates proteins that mediate disruption of the mitochondrial membranes . Positive_regulation CASP8 TNFSF10 17031854 1700282 Here we demonstrated that human prostate cancer cells , but not normal prostate cells , are dramatically sensitized to induced apoptosis and [caspase] *activation* by quercetin . Positive_regulation CASP8 TNFSF10 17031854 1700295 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both enhanced by quercetin . Positive_regulation CASP8 TNFSF10 17186022 1709265 A decrease in Bid content was also associated with inhibition of *induced* [caspase-8] activation . Positive_regulation CASP8 TNFSF10 17268552 1697077 Our data is consistent with the model that activation of oncogenic c-Myc primes mitochondria through a mechanism involving activation of Bak and this priming enables weak *induced* [caspase-8] signals to activate Bax . Positive_regulation CASP8 TNFSF10 17268552 1697078 In conclusion , c-Myc dependent priming of the mitochondrial pathway is critical for the capacity of *induced* [caspase-8] signals to activate effector caspases and for the establishment of lethal caspase feedback amplification loop in human cells . Positive_regulation CASP8 TNFSF10 17545549 1751981 We isolated primary tumor cells from 13 astrocytoma and oligoastrocytoma patients of all four WHO grades of malignancy and compared the levels of *induced* apoptosis induction , long-term tumor cell survival , [caspase] , and caspase target cleavage . Positive_regulation CASP8 TNFSF10 17724141 1822427 Rituximab , a CD20 antibody used to treat certain types of NHL , augmented *induced* [caspase] activation in Ramos RA1 and DoHH2 but not BJAB or SC-1 cells , through modulation of intrinsic rather than extrinsic apoptosis signaling . Positive_regulation CASP8 TNFSF10 17804742 1791214 Although the proteolytic processing of procaspase-3 by TRAIL was partially blocked in glioma cells , cotreatment with silibinin efficiently recovered induced [caspase] *activation* in these cells . Positive_regulation CASP8 TNFSF10 18005243 1860153 Collectively , these data suggest that Shiga toxins trigger monocytic cell apoptosis through the ER stress response , the increased expression of DR5 and , and *activation* of [caspase-8] via a calpain dependent mechanism . Positive_regulation CASP8 TNFSF10 18269677 1865791 In accordance with a previous study of ours , it was found that IgE dependent activation increased *induced* [caspase-8] and caspase-3 cleavage . Positive_regulation CASP8 TNFSF10 18339897 1932011 TTP plasma mediated apoptosis appears to involve cytokine induced acceleration of c-FLIP degradation , sensitizing cells to mediated [caspase-8] *activation* and cell death . Positive_regulation CASP8 TNFSF10 18483385 1910833 Aspirin sensitized human breast cancer cells , but not untransformed human mammary epithelial cells , to induced [caspase] *activation* and apoptosis by a cyclooxygenase-2 independent mechanism . Positive_regulation CASP8 TNFSF10 18665234 1943065 Stable knockdown of bid lead to a pronounced resistance to Fas/CD95- and *induced* [caspase] activation and apoptosis , and significantly increased clonogenic survival . Positive_regulation CASP8 TNFSF10 18980244 1995228 While the proteolytic processing of procaspase-3 by TRAIL was partially blocked in various HCC cells treated with TRAIL alone , co-treatment with quercetin efficiently recovered induced [caspase] *activation* . Positive_regulation CASP8 TNFSF10 19100720 2031211 Bortezomib treatment did not significantly alter plasma membrane amount of DR4 and DR5 but increased *induced* [caspase-8] and caspase-3 activation . Positive_regulation CASP8 TNFSF10 19202127 2086457 In vitro , bortezomib treated tumors had higher tumor necrosis factor related apoptosis inducing ligand ( ) and perforin/granzyme *mediated* [caspase-8] activity , which enhanced their susceptibility to NK-cell lysis . Positive_regulation CASP8 TNFSF10 19590723 2105321 *induced* cell death and [caspase-8] activation are inhibited by cisplatin but not carboplatin . Positive_regulation CASP8 TNFSF10 19597472 2130683 The resulting increase in caspase-8 mRNA and protein expression leads to enhanced *induced* activation of [caspase-8] at the death inducing signaling complex , mitochondrial outer-membrane permeabilization and caspase dependent cell death . Positive_regulation CASP8 TNFSF10 19643600 2124995 These two modifications provoked in the presence of TRAIL the rapid production of and the *activation* of [caspase-8] . Positive_regulation CASP8 TNFSF10 19935877 2167548 Interestingly , in the *presence* of , it increased [caspase-8] binding to the Fas associated death domain (FADD) , but decreased binding of FADD-like interleukin-1beta converting enzyme inhibitory proteins ( FLIPs ) . Positive_regulation CASP8 TNFSF10 20300110 2281693 Cystatin B-deficient melanoma cell lines established by shRNA knockdown displayed increased apoptosis that was associated with enhanced activation of [caspase-8] *induced* by . Positive_regulation CASP8 TNFSF10 20400979 2274066 The ability of ovarian cancer ascites to activate Akt and inhibit *induced* cell death and [caspase] activity was decreased by heat inactivation , but was retained in ascites fractions > 5 kDa . Positive_regulation CASP8 TNFSF10 20400979 2274079 These results suggest that ovarian cancer ascites induces FAK and Akt activation in an alphavbeta5 integrin dependent pathway , which confers protection from *induced* cell death and [caspase] activation . Positive_regulation CASP8 TNFSF10 20563667 2320301 Moreover , activation of caspase-3 , [caspase-8] and caspase-9 *induced* by stimulation of TNF-a , anti-Fas or was significantly inhibited by the knockdown of DELE expression . Positive_regulation CASP8 TNFSF10 20661217 2329328 Although the fact that *induced* [caspase-8] activation was observed in both sensitive and resistant cell lines , Bid cleavage occurred only in sensitive cells or in SKOV3ip1 cells treated with LY294002 . Positive_regulation CASP8 TNFSF10 20804743 2330538 Our results clearly show that PTX augments *mediated* activation of [caspase-8] and induces cleavage of Bid , although PTX alone can not activate caspase-8 . Positive_regulation CASP8 TNFSF10 20876774 2368761 Mechanistic studies revealed that 5-FU mediated suppression of c-FLIP results in increased *induced* recruitment and activation of [caspase-8] at the death inducing signalling complex (DISC) , leading to caspase-3 activation and caspase dependent cell death . Positive_regulation CASP8 TNFSF10 20951126 2364939 The damnacanthal mediated expression of and TNF-R1/TNF-a *results* in [caspase 8] activation , leading to Bid cleavage . Positive_regulation CASP8 TNFSF10 21037225 2370208 Small interfering RNA mediated DR5 silencing rescued cells from sensitizing effects of platinum drugs on *induced* [caspase-8] activation and apoptosis , showing the functional importance of DR5 in the effects observed . Positive_regulation CASP8 TNFSF10 21109947 2366202 *induced* [caspase/p38] activation is responsible for the increased catalytic and invasive activities of Akt . Positive_regulation CASP8 TNFSF10 21152872 2373381 We found that MEKK1/MEKK4 as opposed to ASK1 , are responsible for TRAIL induced c-Jun NH2-terminal kinase (JNK) or p38 activation , and that their catalytic activity is repressed by the caspase-8 inhibitor , suggesting that the [caspase-8] activation *induced* by is indispensible for MEKK activation . Positive_regulation CASP8 TNFSF10 21264227 2380420 Furthermore , TNFa and IFN-? also synergistically enhanced *induced* [caspase-8] activation . Positive_regulation CASP8 TNFSF10 21480222 2538527 Both WWP1 depletion and dominant negative WWP1 overexpression increased the *induced* [caspase-8] recruitment and apoptosis although WWP1 did not regulate FLIP and death receptor levels . Positive_regulation CASP8 TNFSF10 21835222 2532434 Our results show that SAHA decreased the level of c-FLIP , thus favouring the interaction of with the specific death receptors DR4 and DR5 and the consequent *activation* of [caspase-8] . Positive_regulation CASP8 TNFSF10 22310286 2700642 ( TNF ( tumour necrosis factor ) -related apoptosis inducing ligand ) a putative anti-cancer cytokine *induces* apoptosis through DISC ( death inducing signalling complex ) -mediated activation of [caspase-8] and/or cleavage of Bid . Positive_regulation CASP8 TNFSF10 22313685 2600255 In gaining insight into the apoptotic pathway involved in TRAIL sensitization , HDACi were found to potentiate *induced* [caspase-8] activation . Positive_regulation CASP8 TNFSF10 22579651 2632027 Here we show that inhibition of p38a is followed by *mediated* activation of [caspase-8] and FoxO3A dependent HER3 upregulation with consequent overactivation of the MEK-ERK1/2 survival pathway . Positive_regulation CASP8 TNFSF10 22589394 2625147 Stable expression of DARPP-32 in MKN-28 cells enhanced cell survival and suppressed *induced* cytochrome c release and activation of [caspase-8] , -9 , and -3 . Positive_regulation CASP8 TNFSF10 22589394 2625150 Conversely , short hairpin RNA mediated knockdown of endogenous DARPP-32 sensitized the resistant MKN-45 cells to TRAIL induced apoptosis and enhanced *mediated* activation of [caspase-8] , -9 , and -3 . Positive_regulation CASP8 TNFSF10 22589394 2625157 This suggests that upregulation of BCL-xL could play a possible role in blocking the mitochondria intrinsic apoptosis pathway , whereas the DARPP-32 effect on the NF-?B/FLIP ( S ) axis could serve as an additional negative feedback loop that blocks *induced* activation of [caspase-8] . Positive_regulation CASP8 TNFSF10 22753701 2622991 Silibinin activated the extrinsic apoptotic pathway in Hep55.1C cells , as attested by the up-regulation of ( TRAIL ) and TRAIL Death receptor 5 (DR5) transcripts , and by the *activation* of [caspase-3 and -8] . Positive_regulation CASP8 TNFSF10 22799350 2628624 *enhanced* [caspase-8] activation and caspase-3 maturation in B16F10 cells in vitro . Positive_regulation CASP8 TNFSF10 22991197 2734935 We demonstrate that EGFR targeted in combination with BZB *induced* significantly higher [caspase] activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation CASP8 TNFSF10 23180246 2723795 *induces* autophagic protein cleavage through [caspase] activation in melanoma cell lines under arginine deprivation . Positive_regulation CASP8 TNFSF10 23348588 2733980 Instead , *activated* cleavage of [caspase-8] and caspase-3 . Positive_regulation CASP8 TNFSF10 23470529 2750372 Here we report that rapidly *activates* [caspase-8] in a panel of non-small-cell lung carcinomas ( NSCLCs ) . Positive_regulation CASP8 TNFSF10 23640736 2800460 AXIIR is neither required for *induced* [Caspase-8] activation . Positive_regulation CASP8 TNFSF10 23678861 2805760 Inhibition of vacuolar ATPase attenuates the *induced* activation of [caspase-8] and modulates the trafficking of TRAIL receptosomes . Positive_regulation CASP8 TNFSF10 23703388 2792453 Here , we show that despite resistance of Bax/Bak double-deficient cells , *resulted* in [caspase-8] activation and complete processing of the caspase-3 proenzymes . Positive_regulation CASP8 TNFSF10 24097299 2896350 *increased* [caspase-8] activity , without inducing caspase-9/-3 activation and apoptosis . Positive_regulation CASP8 TNFSF10 24525736 2914815 Treatment of hepatoma cells with salubrinal , an inhibitor of eIF2a dephosphorylation , enhances induced eIF2a phosphorylation , CCAAT/enhancer binding protein homologous protein ( CHOP ) expression and [caspase] *activation* . Positive_regulation CASP8 TNFSF10 24525736 2914829 Moreover , knockdown of growth arrest and DNA damage-inducible protein 34 ( GADD34 ) , which recruits protein phosphatase 1 to dephosphorylate eIF2a , enhances *induced* eIF2a phosphorylation , CHOP expression , [caspase] activation and apoptosis . Positive_regulation CASP8 TNFSF10 24525736 2914843 Knockdown of CHOP abrogates the stimulation of induced [caspase] *activation* and apoptosis by salubrinal . Positive_regulation CASP9 CAPN8 11449356 836297 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Positive_regulation CASP9 CAPN8 12358768 994438 Calpain inhibitor III ( MDL-28170 ) reduced caspase activation , suggesting that [caspase] activation was *mediated* by . Positive_regulation CASP9 CAPN8 12917435 1150959 Results showed that 3NP induced death of striatal neurons was preceded by cytochrome c redistribution , transient [caspase-9] processing , and *activation* of , whereas levels of the active/processed form of caspase-3 remained low and were even reduced as compared with control animals . Positive_regulation CASP9 CAPN8 12917442 1151133 Interestingly , the overexpression of parkin induced the activation of an intracellular cysteine protease , calpain , but not [caspase] , and the cytoprotective effect of parkin on alpha-synuclein cytotoxicity was significantly *inhibited* by the presence of inhibitors . Positive_regulation CASP9 CAPN8 16597613 1604330 However , PD-150606 also attenuated caspase-3 activity and apoptosis at 24 h , suggesting *dependent* [caspase] activation . Positive_regulation CASP9 CAPN8 19705411 2151474 Inhibition of not only significantly *reduced* [caspase-9/-3] activities but also completely blocked AIF redistribution . Positive_regulation CASP9 CAPN8 22487998 2601673 Furthermore , inhibition also *prevented* the activation of [caspase-9] and caspase-12 , along with the cleavage of Bid to tBid , all upstream signals for caspase-3 activation . Positive_regulation CASP9 CCND1 12480939 1078960 Bcl-2 controls [caspase] activation *following* a p53 dependent death signal . Positive_regulation CASP9 CCND1 18321638 1904419 Thio-Cl-IB-MECA induced arrest of cell cycle progression in G0/G1 phase at lower concentrations ( up to 20 microM ) and apoptotic cell death at a higher concentration ( 80 microM ) , which were manifested by down-regulation of , c-myc , and CDK4 , *activation* of [caspase-3 and -9] , and cleavage of poly ( ADP-ribose ) polymerase ( PARP ) . Positive_regulation CASP9 EMP1 24338711 2926796 *regulates* [caspase-9] and VEGFC expression and suppresses prostate cancer cell proliferation and invasion . Positive_regulation CASP9 EPHB2 15304372 1322275 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Positive_regulation CASP9 EPHB2 16397410 1512998 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP9 EPHB2 17192846 1701824 These effects were paralleled by disruption of Ras -- > and Akt survival pathways , consequent decreased phosphorylation of both mitochondrial bcl-2 and bad proteins , and [caspase] *activation* . Positive_regulation CASP9 EPHB2 19709398 2139146 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Positive_regulation CASP9 EPHB2 20077196 2178350 Fifty micromolar HQ markedly increased phosphorylation of and *activation* of [caspase-9/-3] , followed by PARP cleavage . Positive_regulation CASP9 EPHB2 20177944 2236725 This [caspase] activation is *mediated* by phosphorylation of Akt and . Positive_regulation CASP9 EPHB2 21219631 2379311 Cell based and in vitro kinase assays indicated that compounds 76.3 and 76.4 directly inhibited *mediated* phosphorylation of [caspase-9] and the p90Rsk-1 kinase , which phosphorylates and inhibits Bad , more effectively than the parent compound 76 . Positive_regulation CASP9 EPHB2 21364665 2361148 dependent multiple [caspase] *activation* by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP9 EPHB2 22193398 2543493 Overexpression of ZnT-1 markedly reduced LDH release and caspase activation following I/R. Knockdown of endogenous ZnT-1 augmented the I/R induced release of LDH and increased [caspase] *activation* following I/R. levels were significantly increased following I/R in cells overexpressing ZnT-1 , while knockdown of ZnT-1 reduced phospho-ERK levels . Positive_regulation CASP9 EPHB2 22554503 2590599 The activation of increased XIAP expression and *led* to decreased [caspase] activation . Positive_regulation CASP9 EPHB2 22560879 2603178 In addition , down-regulation of *resulted* in activation of caspase 3 and [caspase 9] . Positive_regulation CASP9 FAS 10213689 608079 *induced* [caspase] denitrosylation . Positive_regulation CASP9 FAS 10352269 617212 In strict contrast , TPA is an ineffective inhibitor when cell death is induced by the potassium ionophore valinomycin , the specific mitochondrial benzodiazepine ligand PK11195 , or by primary [caspase] *activation* by cross linking . Positive_regulation CASP9 FAS 10364198 620472 EGF stimulation of epithelial cells also inhibited *induced* [caspase] activation and the proteolysis of signaling proteins downstream of the EGF receptor , Cbl and Akt/protein kinase B ( Akt ) . Positive_regulation CASP9 FAS 10391681 626721 ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , [caspase] activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation CASP9 FAS 10391681 626737 M3/6 prevented Fas stimulation of JNK , but did not affect mediated [caspase] *activation* or cell death , demonstrating that JNK activation is not required for these processes . Positive_regulation CASP9 FAS 10405325 629348 *induced* [caspase] activation and nuclear apoptosis , however , were unaffected by the depletion of ATP . Positive_regulation CASP9 FAS 10464143 640285 Suppression of induced *activation* of the [caspase] by IL-1beta was diminished by coadministration with D-galactosamine and reversed by coinjection with an excess amount of uridine . Positive_regulation CASP9 FAS 10545115 564287 Taken together , these findings argue that hDaxx promotes sensitivity to Fas from a nuclear location , probably by modulating the transcription of genes involved in induced [caspase] *activation* and apoptosis . Positive_regulation CASP9 FAS 10647997 662008 By contrast , stimulation alone *resulted* in neither cytochrome c release nor [caspase 9] activation at 3 h , and the increase in the DEVD cleavage activity and apoptosis became evident at later time points . Positive_regulation CASP9 FAS 10706558 673186 In conclusion , in vivo stimulation *causes* [caspase] activation , mitochondrial permeability transition ( decreasing the membrane potential and increasing basal respiration ) , mitochondrial matrix expansion ( as shown by matrix herniation ) , outer mitochondrial membrane rupture , and cytochrome c release . Positive_regulation CASP9 FAS 10749152 681136 These results indicate that mediated [caspase] *activation* elicits two independent cellular responses ; Positive_regulation CASP9 FAS 10766189 684367 The caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp ( OMe ) fluoromethyl ketone ( zVADfmk ) , at concentrations that completely prevent apoptosis and [caspase] activation *induced* by ligation of the death receptor , had only a partial protective effect on onconase induced cell death . Positive_regulation CASP9 FAS 11260077 796097 ligation increased apoptosis and decreased colony growth equally in RARS and controls , but *caused* significantly more [caspase] activation in RARS ( P < 0.01 ) . Positive_regulation CASP9 FAS 11278283 819071 Staurosporine activates MST either caspase-dependently or independently , whereas ligation *activates* it only [caspase-dependently] . Positive_regulation CASP9 FAS 11295536 801391 NH ( 2 ) Cl pretreatment significantly inhibited apoptosis and [caspase] activation *induced* by etoposide or camptothecin , a DNA topoisomerase I poison , but not by staurosporine or stimulation . Positive_regulation CASP9 FAS 11322649 807156 Gamma-interferon ( IFN-gamma ) augments apoptotic response to mistletoe lectin-II via upregulation of L expression and [caspase] *activation* in human myeloid U937 cells . Positive_regulation CASP9 FAS 11359796 816306 In isolated GC B cells , cFLIP ( L ) decays rapidly even without ligation , and this *results* in activation of [caspase] activity and apoptosis . Positive_regulation CASP9 FAS 11368434 817082 *induced* [caspase] activity is increased in RARS bone marrow cells . Positive_regulation CASP9 FAS 11536010 854851 We conclude that ( i ) synergistic induction of apoptosis by C2-ceramide and CD95L depend on a cross-talk between the two signal transduction pathways and that ( ii ) C2-ceramide , independently of its sensitizing effects on dependent [caspase] *activation* , is also capable of triggering an apoptotic signaling cascade that is unaffected by zVAD-fmk mediated caspase inhibition , but promoted by high levels of CD95 expression . Positive_regulation CASP9 FAS 11551934 882156 PI3-kinase inhibition sensitized to apoptosis by increasing and accelerating mediated [caspase] *activation* . Positive_regulation CASP9 FAS 11673515 872831 Thus , *induced* initiation of [caspase] activity at the plasma membrane may in some cells result in local proteolysis of submembrane proteins , leading to generation of membrane vesicles that are highly enriched in active caspase 8 . Positive_regulation CASP9 FAS 11698497 878167 Interleukin (IL)-5 and interferon (IFN)-gamma , two cytokines known to prolong eosinophil survival , inhibited *mediated* apoptosis and [caspase] activation but poorly affected the decrease in DeltaPsi ( m ) . Positive_regulation CASP9 FAS 11699200 878337 Recent work has demonstrated that the degree of spontaneous caspase activation in FHL lymphocytes is attenuated in vitro whereas mediated [caspase] *activation* and apoptosis induction remains unmitigated , and FHL can thus be distinguished from the related chronic disorder of immune regulation termed autoimmune lymphoproliferative syndrome or ALPS . Positive_regulation CASP9 FAS 11834943 911171 Lamivudine was also found to stimulate in vitro induced apoptosis and [caspase] *activation* in pre activated T lymphocytes from healthy donors . Positive_regulation CASP9 FAS 12165276 972790 Further investigation of *mediated* [caspase] activities revealed that supplementation of glutamine significantly decreased caspase-3 and caspase-8 activities in activated T cells . Positive_regulation CASP9 FAS 12207331 983597 In the absence of [caspase] inhibition stimulation did not *result* in cytokine expression , indicating that this proinflammatory signaling pathway is suppressed by active caspases . Positive_regulation CASP9 FAS 12221075 998202 Enforced expression of GPx1 also resulted in inhibition of induced effector [caspase] *activation* , DNA fragmentation , and apoptotic cell death . Positive_regulation CASP9 FAS 12393561 1035696 Moreover , we have previously reported that G-CSF inhibits *induced* [caspase] activation in sideroblastic anemia ( RARS ) . Positive_regulation CASP9 FAS 12393594 1031529 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Positive_regulation CASP9 FAS 12404126 1009731 Structure-function analysis determined that ATP hydrolysis was necessary for P-gp to confer resistance to *induced* [caspase] activation and cell death . Positive_regulation CASP9 FAS 12444127 1017315 These data indicate that TCR ligation can activate nonapoptotic death programs in WT CD8 ( + ) and CD8 ( + ) T blasts that normally are masked by mediated [caspase] *activation* . Positive_regulation CASP9 FAS 12605597 1079488 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block and etoposide *induced* [caspase] activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation CASP9 FAS 12700647 1082037 Myriocin did not modulate the expression of CD95 or CD95L , instead , it interfered with the early steps of mediated [caspase] *activation* . Positive_regulation CASP9 FAS 12760867 1091405 This effect was correlated with an increase in mediated [caspase] *activation* and enhanced cleavage of the caspase substrate poly ( ADP-ribose ) polymerase . Positive_regulation CASP9 FAS 12760867 1091418 Furthermore , the positive effect on mediated [caspase] *activation* by IFN and ribavirin was confirmed by immunocytochemistry for activated caspase-3 and by immunoblot detection of activated caspase-3 , caspase-7 , and caspase-8 . Positive_regulation CASP9 FAS 12760867 1091431 IFN and ribavirin also enhance mediated [caspase] *activation* , which might in part be responsible for the apoptosis promoting effect of these antiviral compounds . Positive_regulation CASP9 FAS 12850790 1109579 Here , newly developed suicide genes , including *inducible* , inducible [caspase] and CD20 are discussed . Positive_regulation CASP9 FAS 12855571 1149826 Importantly , up-regulation of Gadd45 beta by CD40 precedes induced [caspase] *activation* , as well as up-regulation of other NF-kappa B-controlled inhibitors of apoptosis such as Bcl-xL and c-FLIPL . Positive_regulation CASP9 FAS 12930371 1132335 Analysis of *induced* activation of [caspase-8 and -9] showed decreased activity of both caspases in HT , whereas activity of caspase-9 was increased and that of caspase-8 was decreased in GD . Positive_regulation CASP9 FAS 12938225 1133117 Co-incubation with cycloheximide partially reversed protection from apoptosis and increased *stimulated* initiator and effector [caspase] activation , suggesting new protein synthesis is necessary to induce protection upstream of caspase activation . Positive_regulation CASP9 FAS 14576776 1156545 The spontaneous death of CD4+ and CD8+ T cells was not prevented by a decoy CD95 receptor or by a broad-spectrum caspase inhibitor ( zVAD-fmk ) , suggesting that this form of cell death is independent of interaction and [caspase] *activation* . Positive_regulation CASP9 FAS 14617634 1200699 Chemotherapy induced apoptosis of S-type neuroblastoma cells requires [caspase-9] and is *augmented* by stimulation . Positive_regulation CASP9 FAS 14675162 1189367 Both and anti-CD95 antibodies *triggered* [caspase] activation followed by apoptotic death in fully pro-inflammatory astrocytes , whereas resting cells were totally resistant . Positive_regulation CASP9 FAS 14690854 1194688 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , , and TRAIL receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP9 FAS 15144569 1247588 After HuIFN-beta exposure , COH and CC-M2 cells showed increased levels of and FasL proteins , alteration of mitochondrial membrane potential , and *activation* of [caspase-9] , caspase-8 , and caspase-3 in a time dependent manner . Positive_regulation CASP9 FAS 15197350 1347080 The inhibitory activity of TPCK was found to be death ligand-specific since TPCK inhibits TRAIL mediated caspase activity but does not affect *induced* [caspase] activity . Positive_regulation CASP9 FAS 15322156 1286768 Consistent with its role in cell death induction , deletion of caspase-8 in hepatocytes protected them from induced [caspase] *activation* and death . Positive_regulation CASP9 FAS 15370668 1297383 Also , increased expression of the pro-apoptotic Bcl-2 members Bax , Bad and activation of caspase 3 and [caspase 9] , but not the *activation* of caspase 8 or were detected in the NS1 transfected cells . Positive_regulation CASP9 FAS 15648737 1350010 In hypothermic conditions , mediated cytochrome c release from mitochondria of hepatocytes and the proximate downstream *activation* of [caspase-9] were suppressed under mild hypothermic conditions . Positive_regulation CASP9 FAS 15648737 1350024 These findings suggest that mild hypothermia suppresses mediated apoptosis of liver cells by the partial inhibition of signaling events including mitochondrial damage , cytochrome c release , and subsequent apoptosome formation and effector [caspase] *activation* . Positive_regulation CASP9 FAS 15863130 1401088 Binding of Fas ligand or agonistic anti-Fas antibody to the death receptor can *activate* a [caspase-cascade] resulting in apoptosis . Positive_regulation CASP9 FAS 15863130 1401093 Analysis of the Fas apoptotic pathway showed that treatment *induced* caspase-8 activation and concomitantly Bid cleavage , [caspase-9] and caspase-3 activation , PARP cleavage and apoptosis in HeLa and CaSki . Positive_regulation CASP9 FAS 16120269 895980 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Positive_regulation CASP9 FAS 16384930 1547180 JAK2 mutated PV erythroblasts showed lower levels of *induced* [caspase] activation and incomplete caspase mediated cleavage of the erythroid transcription factor GATA-1 , which was entirely degraded in normal erythroblasts on CD95 stimulation . Positive_regulation CASP9 FAS 16527894 1574410 Simultaneously , mediated [caspase] *activation* precipitates differentiation . Positive_regulation CASP9 FAS 16646028 1557216 stimulation activated NF-kappaB and AP-1 , and this response *required* [caspase] activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation CASP9 FAS 17245429 1690845 The nucleo-cytoplasmic translocation of FLASH requires induced [caspase] *activation* and is facilitated by the Crm1 dependent nuclear export pathway . Positive_regulation CASP9 FAS 17304508 1718984 These results suggest the possible involvement of multiple signaling pathways from the MAPK to the subsequent mitochondria- and/or mediated [caspase] *activation* are potential requirements for PCA induced AGS apoptosis . Positive_regulation CASP9 FAS 18386902 1907145 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , [caspase] activation , and *induction* . Positive_regulation CASP9 FAS 18593565 1953613 induced [caspase] *activation* leads to degradation of gp130 , thereby suppressing IL-6 induced phosphorylation of STAT3 ( Tyr ( 705 ) ) and of tyrosine phosphatase SHP2 ( Tyr ( 580 ) ) . Positive_regulation CASP9 FAS 18948840 2041291 All *led* to a reduced DISC formation and diminished initiator [caspase] activity upon CD95-stimulation , whereas a marked heterogeneity in sensitivity to CD95 induced killing was found . Positive_regulation CASP9 FAS 19002587 1991274 In epithelial cells , induced hierarchic [caspase] *activation* is also linked with DEDD , a member of the DED family that binds to keratin (K) intermediate filaments ( IFs ) . Positive_regulation CASP9 FAS 19111607 2031770 However , recent studies have shown that can *induce* nonapoptotic [caspase independent cell death (CICD)] when caspase activity is inhibited . Positive_regulation CASP9 FAS 19680267 2157909 CD95 is a death receptor whose stimulation by either the physiologic ligand or the agonistic antibodies *leads* to the formation of a multi-molecular complex termed DISC ( death inducing signaling complex ) and the subsequent induction of a [caspase-driven] apoptotic signal . Positive_regulation CASP9 FAS 20563667 2320303 Moreover , activation of caspase-3 , caspase-8 and [caspase-9] *induced* by stimulation of TNF-a , or TRAIL was significantly inhibited by the knockdown of DELE expression . Positive_regulation CASP9 FAS 20876774 2368755 Simultaneous downregulation of c-FLIP ( L ) and c-FLIP ( S ) as well as individual knockdown of either isoform by RNA interference significantly enhances TRAIL ( tumour necrosis factor related apoptosis inducing ligand ) - and *induced* [caspase] activation and caspase dependent apoptosis . Positive_regulation CASP9 FAS 22543586 2750634 Furthermore , loss of RAGE increased expression of the death receptor CD95 ( Fas , Apo-1 ) , *dependent* [caspase] activation and extrinsic apoptosis , whereas NF-kB-p65 nuclear translocation was diminished . Positive_regulation CASP9 FAS 23029562 2681064 Blocking the ERK pathway using a pharmacological inhibitor increased the susceptibility of 661W cells to *induced* [caspase] activation and apoptosis . Positive_regulation CASP9 FAS 23530784 2762305 Various methods to inhibit apoptosis including the cell surface receptor pathway inhibitors , [caspase] *inhibitors* , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation CASP9 FAS 24928990 2946829 Real-time detection of CTL function reveals distinct patterns of [caspase] activation *mediated* by versus granzyme B . Positive_regulation CASP9 FAS 24928990 2946857 Thus , we have used a novel , real-time assay to demonstrate the distinct pattern of [caspase] activation *induced* by granzyme B versus in human and murine CTLs . Positive_regulation CASP9 FAS 9637489 513688 Here , we investigated whether the apoptosis occurring after TCR/CD9 stimulation is associated with a death pathway involving Fas stimulation and mediated [caspase] *activation* as observed in activation induced cell death ( AICD ) . Positive_regulation CASP9 FAS 9694885 524308 Our results demonstrate that whereas mediated activation of caspase 3 *requires* an upstream [caspase] activity that is zVAD-fmk-sensitive , the initial cleavage of caspase 3 during granule mediated cell death is insensitive to zVAD-fmk , suggesting that caspase 3 is cleaved directly by granzyme B in vivo . Positive_regulation CASP9 FOXO1 12438947 1016841 and decrease in Bad phosphorylation , cytochrome release , [caspase-9] *activation* , and translocation of were observed after simvastatin treatment , effects reversed by LY294002 . Positive_regulation CASP9 IFI27 18652763 1942578 Carnosic acid also augmented these effects when induced by a low ( physiological ) concentration of arsenic trioxide , which was associated with upregulation of and *activation* of [caspase-9] . Positive_regulation CASP9 IL1B 16305880 1485923 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , and interleukin-6 , and *activation* of caspase-1 , caspase-3 and [caspase-11] . Positive_regulation CASP9 MAOA 17883400 1830027 Two unrelated inhibitors *reduced* [caspase] activation . Positive_regulation CASP9 MAP2K6 16397410 1513004 While TRAIL sensitivity in tumors has been linked to c-myc- and *induced* enhancement of [caspase] activation , our recent study identified a third input controlling TRAIL sensitivity , namely the Akt-mTOR pathway . Positive_regulation CASP9 MAP2K6 16672322 1583772 Inhibition of the ERK activator , as well as of p38 , significantly *reduced* [caspase] activation and necrosis , whereas c-Jun N-terminal kinase (JNK) inhibition diminished only caspase activity . Positive_regulation CASP9 MAP2K6 21364665 2361154 dependent multiple [caspase] *activation* by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Positive_regulation CASP9 MMP28 13679861 1140657 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP9 MMP28 15557813 1340913 We also observed ceramide/ DMS induced disruption of mitochondrial and *activation* of [caspase- 9] and -3 in a radiation-dose dependent manner . Positive_regulation CASP9 MMP28 23507522 2766850 Compounds 2-4 strongly induced apoptosis in CCRF-CEM cells via caspases 3/7 , caspase 8 and [caspase 9] *activation* and disruption of . Positive_regulation CASP9 MMP7 13679861 1140672 Inhibition of mitochondrial by transfection with Bcl-2 or the Cytomegalovirus UL37 gene product vMIA *prevented* [caspase] activation and cell death . Positive_regulation CASP9 MMP7 15557813 1340928 We also observed ceramide/ DMS induced disruption of mitochondrial and *activation* of [caspase- 9] and -3 in a radiation-dose dependent manner . Positive_regulation CASP9 MMP7 23507522 2766865 Compounds 2-4 strongly induced apoptosis in CCRF-CEM cells via caspases 3/7 , caspase 8 and [caspase 9] *activation* and disruption of . Positive_regulation CASP9 RNASE1 15620724 1357865 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and *induced* [caspase] activation in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP9 RNASE1 15620724 1358099 We find that RC-RNase and *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP9 RNASE7 15620724 1357873 In this study , we use substrate cleavage assays to systematically investigate RC-RNase- and *induced* [caspase] activation in HL-60 , MCF-7 , and SK-Hep-1 cells . Positive_regulation CASP9 RNASE7 15620724 1358107 We find that RC-RNase and *induce* mitochondria mediated [caspase] activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation CASP9 SPHK1 11238741 791094 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Positive_regulation CASP9 TNF 10425195 632763 *induces* [caspase] activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation CASP9 TNF 10586080 571808 Silymarin also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated *induced* cytotoxicity and [caspase] activation . Positive_regulation CASP9 TNF 10593992 572966 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Positive_regulation CASP9 TNF 10764744 698801 Addition of H ( 2 ) O ( 2 ) prevented induced apoptosis and [caspase] *activation* , an effect prevented by simultaneous addition of catalase . Positive_regulation CASP9 TNF 10820260 694395 induced cytotoxicity , [caspase] *activation* , and lipid peroxidation were also abolished by vesnarinone . Positive_regulation CASP9 TNF 10843709 700181 Resveratrol also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated induced cytotoxicity and [caspase] *activation* . Positive_regulation CASP9 TNF 11228746 581012 induced *activation* of [caspase] activity was blocked by all three types of quenchers . Positive_regulation CASP9 TNF 11836241 929143 Cytochrome c was released from mitochondria , and [caspase-9] was activated in Bax- or Bak-deficient cells in *response* to but not in cells deficient in both . Positive_regulation CASP9 TNF 11847111 912600 mediated [caspase] *activation* and block of differentiation are dependent upon the expression of PW1 , but occur independently of NFkappaB activation . Positive_regulation CASP9 TNF 12036088 949073 *promotes* [caspase] activation and apoptosis in human fetal membranes . Positive_regulation CASP9 TNF 12080044 976130 We also showed that stable overexpression of A20 inhibits apoptosis and [caspase] activation *induced* by . Positive_regulation CASP9 TNF 12431778 1015390 Our results demonstrate that TGF-beta1 can decrease TNF-alpha induced apoptosis in murine osteoblasts at least in part by attenuating *induced* [caspase] gene expression . Positive_regulation CASP9 TNF 12663669 1092736 In the presence of cycloheximide , or interleukin-1 *initiates* [caspase] activation , loss of mitochondrial membrane potential ( DeltaPsi ) , DNA degradation , and nuclear condensation and fragmentation characteristic of apoptotic cell death in human vascular endothelial cells ( EC ) . Positive_regulation CASP9 TNF 12763364 1093897 The latter and mediated [caspase] *activation* was attenuated by prostaglandin E ( 2 ) . Positive_regulation CASP9 TNF 12800192 1098921 The antioxidants N-acetylcysteine , reduced glutathione , lipoic acid and ascorbic acid markedly reduced the enhancing effect of the hormone on induced [caspase] *activation* . Positive_regulation CASP9 TNF 12800192 1098934 The effect of calcitriol on DeltaPsi was mimicked by rotenone , which increased both the drop in DeltaPsi and [caspase] activation *induced* by . Positive_regulation CASP9 TNF 15033766 1184115 The antioxidants N-acetylcysteine , glutathione , lipoic acid , and ascorbic acid markedly reduced the effect of the hormone on *induced* [caspase] activation , attesting to the involvement of reactive oxygen species ( ROS ) in the cross-talk between the hormone and the cytokine . Positive_regulation CASP9 TNF 15283855 1277828 In the *presence* of or endotoxin ( LPS ) , blockade of CD18 ( beta2 chain ) with mAb markedly increased [caspase] activation in PMN on fibrinogen . Positive_regulation CASP9 TNF 15452110 1341980 These mutant cells exhibited a defect in induced [caspase] *activation* , Bid cleavage , and release of cytochrome c . Positive_regulation CASP9 TNF 16263807 1539298 However , pro-caspase-8 levels were low , and [caspase-9] was also activated in *response* to , characteristic of what have been termed type II cells . Positive_regulation CASP9 TNF 16532377 1555291 Inhibition of the p38 and/or the JNK death pathways reduced [caspase] activation *induced* by oxidative stress , hyperosmotic shock and . Positive_regulation CASP9 TNF 16631528 1552357 We report that DDC strongly inhibits [caspase] activation , loss of DeltaPsim , and cell death *induced* by or etoposide . Positive_regulation CASP9 TNF 16729970 1570511 Caspase-12 , but not [caspase-9] , was activated in *response* to , indicating that an endoplasmic reticulum ( ER ) /calcium dependent pathway may be involved . Positive_regulation CASP9 TNF 16966373 1633430 By using a large panel of genetically modified murine embryonic fibroblasts , we show here that , in *response* to , caspase-8 cleaves and activates [caspase-9] in an apoptosome independent manner . Positive_regulation CASP9 TNF 17047073 1635895 Importantly , down-regulation of TRAIL by small interfering RNA silencing decreased mediated Adriamycin induced [caspase] *activation* and apoptosis , and thus enhanced breast cancer cell resistance to Adriamycin . Positive_regulation CASP9 TNF 17125837 1686486 ATD5 could also reduce the TNF-alpha mediated cytotoxicity and inhibit mediated [caspase] *activation* on L929 cells in a dose dependent manner . Positive_regulation CASP9 TNF 17599041 1848500 We have recently shown that *induces* [caspase dependent and -independent] JNK activation and ROS accumulation in cellular FLICE-inhibitory protein ( c-Flip ) ( -/- ) murine embryonic fibroblasts ( MEFs ) . Positive_regulation CASP9 TNF 17636167 1770714 In some cells , however , can also *cause* mitochondrial depolarization and [caspase-9] activation . Positive_regulation CASP9 TNF 18023359 1832137 Mitochondrial apoptotic inducer bax , and the suppressor bcl-2 were evaluated using western blotting at 48 h. Results indicated that *increased* [caspase] activities and resulted in a significant ( p = 0.001 ) increase in bax/bcl-2 ratio . Positive_regulation CASP9 TNF 18467439 1938884 However , XIAP small interfering RNA restored *induced* [caspase] signaling and apoptosis in Hec-1A cells ; Positive_regulation CASP9 TNF 19246452 2062626 CLN2-deficient cells exhibited a defect in induced Bid cleavage , release of cytochrome c , and [caspase-9] and -3 *activation* . Positive_regulation CASP9 TNF 19345705 2094389 Finally , reconstitution of PPT1 activity in mutant cells was accompanied by resensitization to *induced* [caspase] activation and toxicity . Positive_regulation CASP9 TNF 19440308 2078415 Muscle regeneration is , at least in part , regulated by caspase activation , and AVP abrogated *dependent* [caspase] activation . Positive_regulation CASP9 TNF 20200974 2299818 Silencing FOXO1 using siRNA in vitro significantly reduced *induced* apoptosis and [caspase] activity in differentiated chondrocytes . Positive_regulation CASP9 TNF 20563667 2320302 Moreover , activation of caspase-3 , caspase-8 and [caspase-9] *induced* by stimulation of , anti-Fas or TRAIL was significantly inhibited by the knockdown of DELE expression . Positive_regulation CASP9 TNF 21269505 2392752 is also *required* for appropriate regulation of [caspase] genes . Positive_regulation CASP9 TNF 21893119 2506494 Conversely , *activation* of [caspase] by exogenous required IL-13 , TWEAK , and Fn14 . Positive_regulation CASP9 TNF 24684347 2935147 Smac-mimetic 1-induced loss of cIAPs correlated with inhibition of mediated NF-?B activation , [caspase] *activation* , and tumor cell killing . Positive_regulation CASP9 TNF 9531309 496836 Furthermore , only murine but not IL-1alphabeta *increased* [caspase] activity and apoptosis . Positive_regulation CASP9 TNF 9885230 584461 *induced* [caspase] activation was accompanied by a decrease in the ability of neutrophils to release superoxide anion . Positive_regulation CASP9 TNF 9885230 584487 Granulocyte-macrophage colony stimulating factor inhibited *induced* [caspase] activation and apoptosis , while reversing the diminution in superoxide release . Positive_regulation CASP9 TNFSF10 11677236 896127 Combining and interferon in vitro , synergistically *induced* apoptosis and [caspase] activation in breast cancer cells . Positive_regulation CASP9 TNFSF10 12154014 971661 Conversely , reduction of the Bcl-x ( L ) /tBID ratio by inhibition of CK2 renders such cancer cells sensitive to *induced* activation of [caspase-9] and apoptosis . Positive_regulation CASP9 TNFSF10 12592338 1060367 *activated* caspase-8 but not [caspase-9] or -10 in HL60 cells . Positive_regulation CASP9 TNFSF10 12815069 1103423 In addition , overexpression of cleavage-site mutant c-IAP1 makes cells more resistant to *induced* [caspase] activation . Positive_regulation CASP9 TNFSF10 14644092 1188263 Furthermore , the enhancement extended to *induced* [caspase-activation] . Positive_regulation CASP9 TNFSF10 14690854 1194689 The pathways leading to cell death involve the activation of one or more death receptor pathways ( i.e. , TNF-alpha , Fas , and receptors ) , chemokine receptor signaling , cytokine dysregulation , [caspase] *activation* , calcium mobilization , and loss of mitochondrial membrane potential . Positive_regulation CASP9 TNFSF10 15197350 1347067 In this study , we show that TPCK inhibits *induced* [caspase] activity but potentiates wortmannin dependent caspase activity in prostatic carcinoma cell lines . Positive_regulation CASP9 TNFSF10 15558024 1361134 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both promoted by amiloride . Positive_regulation CASP9 TNFSF10 15569667 1368294 Here we demonstrate that human breast cancer cells , but not normal mammary epithelial cells , are dramatically sensitized to *induced* apoptosis and [caspase] activation by peroxisome proliferator activated receptor gamma ( PPARgamma ) agonists of the thiazolidinedione ( TZD ) class . Positive_regulation CASP9 TNFSF10 15792357 1386646 Western blot analysis showed that the hypoxia augmented *induced* PARP cleavage as well as the activation of caspase-8 and caspase-3 , but not [caspase-9] . Positive_regulation CASP9 TNFSF10 16103097 1444529 Generation of ROS by CCCP was responsible for *induced* Bax and [caspase] activation because scavenging ROS completely abrogated apical caspase-8 activation and further downstream events leading to cell death . Positive_regulation CASP9 TNFSF10 16475717 1524138 *induced* the activation of caspases-2 , -3 and -8 , but not the activation of [caspase-9] , in the Mel-resistant TE-671 cells . Positive_regulation CASP9 TNFSF10 17031854 1700283 Here we demonstrated that human prostate cancer cells , but not normal prostate cells , are dramatically sensitized to induced apoptosis and [caspase] *activation* by quercetin . Positive_regulation CASP9 TNFSF10 17031854 1700296 The mediated *activation* of [caspase] , and PARP ( poly ( ADP-ribose ) polymerase ) cleavage were both enhanced by quercetin . Positive_regulation CASP9 TNFSF10 17545549 1751982 We isolated primary tumor cells from 13 astrocytoma and oligoastrocytoma patients of all four WHO grades of malignancy and compared the levels of *induced* apoptosis induction , long-term tumor cell survival , [caspase] , and caspase target cleavage . Positive_regulation CASP9 TNFSF10 17724141 1822428 Rituximab , a CD20 antibody used to treat certain types of NHL , augmented induced [caspase] *activation* in Ramos RA1 and DoHH2 but not BJAB or SC-1 cells , through modulation of intrinsic rather than extrinsic apoptosis signaling . Positive_regulation CASP9 TNFSF10 17804742 1791215 Although the proteolytic processing of procaspase-3 by TRAIL was partially blocked in glioma cells , cotreatment with silibinin efficiently recovered *induced* [caspase] activation in these cells . Positive_regulation CASP9 TNFSF10 18483385 1910834 Aspirin sensitized human breast cancer cells , but not untransformed human mammary epithelial cells , to *induced* [caspase] activation and apoptosis by a cyclooxygenase-2 independent mechanism . Positive_regulation CASP9 TNFSF10 18665234 1943066 Stable knockdown of bid lead to a pronounced resistance to Fas/CD95- and *induced* [caspase] activation and apoptosis , and significantly increased clonogenic survival . Positive_regulation CASP9 TNFSF10 18791828 1976150 *induced* [caspase 9] cleavage accompanied by activation of cytochrome C and Apaf-1 were not mediated by anti-Fas antibody . Positive_regulation CASP9 TNFSF10 18829553 1971027 XIAP inhibition combined with TRAIL even breaks Bcl-2 imposed resistance by converting type II cells that depend on the mitochondrial contribution to the death receptor pathway to type I cells in which induced *activation* of caspase-3 and [caspase-9] and apoptosis proceeds irrespective of high Bcl-2 levels . Positive_regulation CASP9 TNFSF10 18980244 1995229 While the proteolytic processing of procaspase-3 by TRAIL was partially blocked in various HCC cells treated with TRAIL alone , co-treatment with quercetin efficiently recovered induced [caspase] *activation* . Positive_regulation CASP9 TNFSF10 20400979 2274067 The ability of ovarian cancer ascites to activate Akt and inhibit *induced* cell death and [caspase] activity was decreased by heat inactivation , but was retained in ascites fractions > 5 kDa . Positive_regulation CASP9 TNFSF10 20400979 2274080 These results suggest that ovarian cancer ascites induces FAK and Akt activation in an alphavbeta5 integrin dependent pathway , which confers protection from *induced* cell death and [caspase] activation . Positive_regulation CASP9 TNFSF10 20563667 2320304 Moreover , activation of caspase-3 , caspase-8 and [caspase-9] *induced* by stimulation of TNF-a , anti-Fas or was significantly inhibited by the knockdown of DELE expression . Positive_regulation CASP9 TNFSF10 21109947 2366203 *induced* [caspase/p38] activation is responsible for the increased catalytic and invasive activities of Akt . Positive_regulation CASP9 TNFSF10 22991197 2734936 We demonstrate that EGFR targeted in combination with BZB *induced* significantly higher [caspase] activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation CASP9 TNFSF10 23180246 2723796 *induces* autophagic protein cleavage through [caspase] activation in melanoma cell lines under arginine deprivation . Positive_regulation CASP9 TNFSF10 24525736 2914816 Treatment of hepatoma cells with salubrinal , an inhibitor of eIF2a dephosphorylation , enhances *induced* eIF2a phosphorylation , CCAAT/enhancer binding protein homologous protein ( CHOP ) expression and [caspase] activation . Positive_regulation CASP9 TNFSF10 24525736 2914830 Moreover , knockdown of growth arrest and DNA damage-inducible protein 34 ( GADD34 ) , which recruits protein phosphatase 1 to dephosphorylate eIF2a , enhances induced eIF2a phosphorylation , CHOP expression , [caspase] *activation* and apoptosis . Positive_regulation CASP9 TNFSF10 24525736 2914844 Knockdown of CHOP abrogates the stimulation of *induced* [caspase] activation and apoptosis by salubrinal . Positive_regulation CASQ2 EDN2 20529095 2271410 *Role* of in the effects of isoprenaline on potassium currents and [calsequestrin 2] expression in the heart . Positive_regulation CASR IL1B 15684428 1388412 *stimulated* endogenous [CASR] gene transcripts and transfected promoter reporter activity in human thyroid C-cells ( TT cells ) and kidney proximal tubule ( HKC ) cells . Positive_regulation CAST CAPN8 14685690 1179354 Prolonged activation also *promotes* degradation of [calpastatin] . Positive_regulation CAST CAPN8 16385561 1520158 The restoration of pCREB by protein phosphatase (PP)-1/2A inhibitors or the inhibition of excessive *activation* of by [calpain inhibitor] did not reduce OGD/reoxygenation induced LDH release . Positive_regulation CAST CAPN8 1829675 161380 Cyclin proteolysis at micromolar free Ca2+ , is not inhibited by [calpastatin] , and therefore does not *involve* . Positive_regulation CAST CAPN8 19646546 2157631 [calpastatin] degradation was *prevented* by inhibitors of either or caspase-8 . Positive_regulation CAST CAPN8 22688056 2633602 In this study , we analyzed the potential therapeutic efficacy of inhibiting the *activation* of by a novel [calpain inhibitor] in aged 3xTgAD mice with well established cognitive impairment , plaques , and tangles . Positive_regulation CAST CAPN8 2553696 120663 Unautolyzed m-calpain , autolyzed m-calpain , and autolyzed *required* less Ca2+ for half-maximal binding to [calpastatin] than for half-maximal activity . Positive_regulation CAST CAPN8 2553696 120704 Unautolyzed , however , *required* slightly more Ca2+ for half-maximal binding to [calpastatin] than for half-maximal activity . Positive_regulation CAT ARSG 10484072 643922 *increased* the [chloramphenicol acetyl transferase (CAT)] activity via a CAT reporter construct containing a dioxin-responsive element in Hepa 1c1c7 cells , indicating involvement of the aryl hydrocarbon receptor . Positive_regulation CAT EPHB2 16819299 1581439 Inhibition of and p38 MAPK *reduced* the induction of [catalase] activity resulting from overexpression of CAGE , and inhibition of catalase reduced CAGE promoted motility . Positive_regulation CAT EPHB2 16819299 1581453 We conclude that CAGE enhances the motility of cancer cells by activating and p38 MAPK , *inducing* [catalase] activity , and reducing ROS levels . Positive_regulation CAT FOXO1 17186497 1701655 Constitutively active *increased* the expression of [catalase] . Positive_regulation CAT FOXO1 17186497 1701657 Furthermore , expression of dominant negative Akt and constitutively active *increased* [catalase] transcription , respectively . Positive_regulation CAT FOXO1 19426753 2090220 overexpression could not *prevent* aging induced reduction in [catalase] , CuZu-SOD , and Mn-SOD mRNA in skeletal muscle . Positive_regulation CAT GPR115 11751593 898417 and VP16/PR-B *induced* ( approximately 3- to 4-fold ) [chloramphenicol acetyltransferase (CAT)] activity in a progesterone dependent manner , suggesting PR-dimer formation . Positive_regulation CAT GPR132 11751593 898406 and VP16/PR-B *induced* ( approximately 3- to 4-fold ) [chloramphenicol acetyltransferase (CAT)] activity in a progesterone dependent manner , suggesting PR-dimer formation . Positive_regulation CAT GPR87 11751593 898486 and VP16/PR-B *induced* ( approximately 3- to 4-fold ) [chloramphenicol acetyltransferase (CAT)] activity in a progesterone dependent manner , suggesting PR-dimer formation . Positive_regulation CAT IL1B 10956548 724792 Point mutations of NF-IL6 and cAMP response element ( CRE ) in this region reduced both basal and *stimulated* production of [CAT] ; Positive_regulation CAT IL1B 11052811 743465 The *stimulated* the [collagenase-CAT] and AP-1-CAT activities in a dose dependent manner with respect to the amount of DNA used in transfections . Positive_regulation CAT RARB 11358817 816129 Furthermore , induction with all of the compounds was accompanied by up-regulation of mRNA levels of the nuclear and specific *activation* of a reporter gene construct ( [SVbetaRE-CAT] ) that contains the canonical RA response element located in the RARbeta promoter . Positive_regulation CAT TNF 10500286 648173 In U937 cells , dexamethasone ( DEX ) downregulates [CAT] expression *induced* by either phorbol myristate acetate ( PMA ) , or granulocyte/macrophage-colony stimulating factor ( GM-CSF ) . Positive_regulation CAT TNF 15621052 1358410 *increased* [catalase] activity in the ventricles ( 15.8+/-1.2 I.U./mg for controls vs. 19.9+/-1.1 I.U/mg for TNF alpha , p < 0.05 ) . Positive_regulation CAT TNF 18761070 1975445 Pretreatment with CGX significantly restored the reduction of [catalase] activity and glutathione ( GSH ) content , but not superoxide dismutase (SOD) activity , and it *inhibited* the CCl ( 4 ) -induced high expression of iNOS and in hepatic tissue . Positive_regulation CAT TNF 2059367 162103 In SW620 and HT29 cells transfected with the HIV-1 long terminal repeat ( LTR ) linked to the chloramphenicol acetyl transferase (CAT) reporter gene , an intact HIV-1 enhancer element was required for *stimulation* of [CAT] activity by and phorbol ester . Positive_regulation CAT TNF 7628389 316416 PMA , a known activator of PKC , and *had* a similar inhibitory effect on P450c17 expression , testosterone production , and [Cyp17-CAT] activity . Positive_regulation CAV1 CD14 24244013 2879577 We observed that LPS interaction with in endothelial cells *induced* Src dependent [caveolin-1] phosphorylation at Tyr ( 14 ) . Positive_regulation CAV1 EPHB2 19625610 2142930 In conclusion , these results demonstrated that EGF induced DNA synthesis and cell migration are mediated by [caveolin-1] , which is *activated* by Src , FAK , PI3K/Akt , , and MMP-2 signals in mouse ES cells . Positive_regulation CAV1 EPHB2 23428975 2744227 Furthermore , [Cav-1] increased proMMP-1 and VEGF secretion in HGFs , and the VEGF secretion was statistically *suppressed* by JNK inhibitor SP600125 , but not inhibitor PD98059 . Positive_regulation CAV1 FAS 19934968 2167472 Simvastatin also decreased cholesterol content in lipid raft fractions , suppressed [caveolin-1] expression in the lipid rafts , and *induced* translocation into lipid rafts , suggesting that simvastatin may inhibit the prosurvival PI3K/Akt pathway and trigger caspase-3 dependent apoptotic cell death through the modulation of lipid rafts . Positive_regulation CAV1 FOXO1 18444242 1984035 This induction of [caveolin-1] by APC is *mediated* by both , a member of the Forkhead family of transcription factor , and c-myc . Positive_regulation CAV1 GPR115 16997880 1628504 These data support our hypothesis that increased Po ( 2 ) at birth promotes dissociation of caveolin-1 and NOS-3 , with an increase in their activities , and that PKC and an oxygen-sensitive cell surface *regulate* [caveolin-1] and NOS-3 interactions in fetal and neonatal lung MVECs . Positive_regulation CAV1 GPR132 16997880 1628493 These data support our hypothesis that increased Po ( 2 ) at birth promotes dissociation of caveolin-1 and NOS-3 , with an increase in their activities , and that PKC and an oxygen-sensitive cell surface *regulate* [caveolin-1] and NOS-3 interactions in fetal and neonatal lung MVECs . Positive_regulation CAV1 GPR87 16997880 1628573 These data support our hypothesis that increased Po ( 2 ) at birth promotes dissociation of caveolin-1 and NOS-3 , with an increase in their activities , and that PKC and an oxygen-sensitive cell surface *regulate* [caveolin-1] and NOS-3 interactions in fetal and neonatal lung MVECs . Positive_regulation CAV1 HBEGF 12372346 996362 We observed that EGF and , but not heregulin , *promoted* [caveolin-1] phosphorylation in A431 cells , suggesting that these responses are linked to EGF receptor activation and not solely occurring via the activation of other endogenous ErbB family members . Positive_regulation CAV1 MAP2K6 22824620 2670689 Additionally , inhibitor ( U0126 ) significantly *attenuated* arsenite induced expression of [Caveolin-1] , IKKß and COX-2 while reducing eNOS expression . Positive_regulation CAV1 S100B 16551628 1555606 *increased* the activation of Src kinase and tyrosine phosphorylation of [caveolin-1] in VSMCs . Positive_regulation CAV1 TNF 11311151 804932 Interestingly , stimulation of fibroblasts with *resulted* in a partial shift of its p55 receptor to caveolin enriched membrane fractions and the appearance of [caveolin-sensitive] neutral sphingomyelinase activity in the non-caveolar fractions . Positive_regulation CAV1 TNF 18803934 1965118 [Caveolin-1] was significantly *induced* by , which was further amplified by linoleic acid and blocked by alpha-linolenic acid . Positive_regulation CAV1 TNF 22241747 2629509 [Cav-1] overexpression significantly increased Orai1 expression and SOCE , especially in the *presence* of . Positive_regulation CAV2 EPHB2 15781236 1385453 Direct interaction between ERK and [caveolin-2] was confirmed by immunoprecipitation and phosphorylated *increased* the specific interaction in response to insulin . Positive_regulation CAV2 SYT8 11891287 922722 , on the other hand , *increased* the rate of activation of Ca(v)2 .3 and [Ca(v)2] .2 in all permeating ions tested . Positive_regulation CAV2 TNF 11311151 804933 Interestingly , stimulation of fibroblasts with *resulted* in a partial shift of its p55 receptor to caveolin enriched membrane fractions and the appearance of [caveolin-sensitive] neutral sphingomyelinase activity in the non-caveolar fractions . Positive_regulation CAV3 EPHB2 20372051 2360293 Ultrastructural cytochemistry , confocal microscopy and immunoblotting revealed a reduction in [Cav-3] expression and an *activation* of ( extracellular-signal regulated kinase ) 48 hours after Trypanosoma cruzi infection of cultured cardiac myocytes . Positive_regulation CAV3 EPHB2 20372051 2360294 These data suggest that the reduction in [Cav-3] expression and the *activation* of during the early phase of infection may contribute to the pathogenesis of chagasic cardiomyopathy . Positive_regulation CAV3 EPHB2 20685979 2299172 [Ca(v)3] .2 T-type Ca2+ channel dependent *activation* of in paraventricular thalamus modulates acid induced chronic muscle pain . Positive_regulation CAV3 EPHB2 20685979 2299173 Our findings suggest that [Ca(v)3] .2 T-channel dependent *activation* of in PVA is required for the development of acid induced chronic mechanical hyperalgesia . Positive_regulation CAV3 TNF 11311151 804934 Interestingly , stimulation of fibroblasts with *resulted* in a partial shift of its p55 receptor to caveolin enriched membrane fractions and the appearance of [caveolin-sensitive] neutral sphingomyelinase activity in the non-caveolar fractions . Positive_regulation CBFA2T2 ANGPT1 10521483 653143 Furthermore , stimulation of Tek expressing cells with *results* in phosphorylation of both Tek and [p85] and in activation of endothelial cell migration and survival pathways that are dependent in part on phosphatidylinositol 3-kinase . Positive_regulation CBFA2T2 PECAM1 20723025 2357014 To investigate the possibility that *regulates* the formation of the [Gab1-p85] signaling complexes , and the potential effect of such interactions on GPVI mediated platelet activation in platelets . Positive_regulation CBFA2T2 TNF 20541701 2271705 *promoted* tRXRalpha interaction with the [p85alpha] , activating PI3K/AKT signaling . Positive_regulation CBFA2T2 TNF 8557661 347514 stimulation of 3T3-L1 adipocytes also *promotes* the association of the [p85] regulatory subunit of phosphatidylinositol 3-kinase ( PI 3-kinase ) with IRS-1 and also its tyrosine phosphorylation . Positive_regulation CBL EFNB1 12794130 1098029 In contrast , stimulation of Jurkat cells with the EphB receptor ligand does not *cause* [Cbl] phosphorylation . Positive_regulation CBX1 FOLR1 8104505 229108 In the MSA treated KK mice , GK activity did not change and [CBX] activity decreased , and only activity *increased* significantly . Positive_regulation CBX2 FOLR1 8104505 229109 In the MSA treated KK mice , GK activity did not change and [CBX] activity decreased , and only activity *increased* significantly . Positive_regulation CBX3 FOLR1 8104505 229110 In the MSA treated KK mice , GK activity did not change and [CBX] activity decreased , and only activity *increased* significantly . Positive_regulation CBX4 FOLR1 8104505 229111 In the MSA treated KK mice , GK activity did not change and [CBX] activity decreased , and only activity *increased* significantly . Positive_regulation CBX4 ZFP57 20808772 2313978 Levels of both and PcG proteins inversely correlated with those of reactive oxygen species ( ROS ) in senescing MEFs , but the treatment of Zfp277 ( -/- ) MEFs with an antioxidant *restored* the binding of PRC2 but not [PRC1] to the Ink4a/Arf locus . Positive_regulation CBX5 FOLR1 8104505 229112 In the MSA treated KK mice , GK activity did not change and [CBX] activity decreased , and only activity *increased* significantly . Positive_regulation CBX6 FOLR1 8104505 229113 In the MSA treated KK mice , GK activity did not change and [CBX] activity decreased , and only activity *increased* significantly . Positive_regulation CBX7 FOLR1 8104505 229114 In the MSA treated KK mice , GK activity did not change and [CBX] activity decreased , and only activity *increased* significantly . Positive_regulation CBX8 ALOX5 1551235 184051 A specific <5'-lipoxygenase> inhibitor , A63162 *inhibited* [PC3] and U937 proliferation . Positive_regulation CBX8 F2R 17492768 1772352 Activation of *induced* dynamic cytoskeletal reorganization and reduced [PC-3] binding to collagen I , collagen IV , and laminin ( P < 0.01 ) but not fibronectin . Positive_regulation CBX8 FOLR1 8104505 229115 In the MSA treated KK mice , GK activity did not change and [CBX] activity decreased , and only activity *increased* significantly . Positive_regulation CBX8 TNF 17043111 1674676 GFLX significantly attenuated the expression of IL-8 mRNA in *stimulated* [PC-3] cells and down-regulated the transcriptional activity of the 5'-flanking region of the IL-8 gene from -1481 to +44 bp . Positive_regulation CBX8 TNF 22426696 2577618 Snail expression was significantly down-regulated by treatment with GA ( 0.5 µmol/L ) in the *stimulated* [PC3] cells . Positive_regulation CBY1 NES 19940019 2190516 Importantly , the NLS- and *dependent* shuttling of [Cby] modulates the dynamic intracellular localization of beta-catenin . Positive_regulation CBY3 NES 19940019 2190517 Importantly , the NLS- and *dependent* shuttling of [Cby] modulates the dynamic intracellular localization of beta-catenin . Positive_regulation CCAR1 TNFSF10 20137126 2208049 *induced* apoptosis in RPMI8226 cells , the expression level of genes bcl-2 , mcl-1 , [CARP1] , CARP2 , XIAP and cFLIP decreased , while the expression level of Bax increased , but the expression level of caspase-3 and NF-kappaB P65 ( RelA ) proteins decreased . Positive_regulation CCK CCND1 18845673 1988547 Analysis of cyclin and cdk mRNA and protein abundance revealed that [CCK] overexpression *increased* cyclin A , cyclin B , cyclin E , cdk1 , and cdk2 with no change in , cyclin D2 , cyclin D3 , cdk4 , or cdk6 in mouse and human islets . Positive_regulation CCK EPHB2 9950825 595761 In contrast , infection with adenovirus bearing rasN17 increased basal amylase release , inhibited CCK mediated JNK activation , had no effect on [CCK] *activation* of , and inhibited DNA synthesis . Positive_regulation CCK MAP2K6 7611406 312035 *Activation* of and Ras by [cholecystokinin] in rat pancreatic acini . Positive_regulation CCKBR MAP2K6 12761477 1091538 A transiently transfected activated ras vector stimulated [gastrin/CCKB receptor] transcriptional activities in both Colo320HSR and LoVo cells , but these ras increased activities were *inhibited* by a specific inhibitor , PD98059 . Positive_regulation CCL1 EPHB2 16436136 1516399 Using various selective inhibitors for signaling molecules , we found that the inductions of IL-8 , MCP-1 , and [I-309] were *mediated* by either SCF activated or TNF-alpha activated p38 MAPK , while the induction of IP-10 by TNF-alpha was mediated by both activated p38 MAPK and NF-kappaB . Positive_regulation CCL1 IL1B 9079810 420758 Thus , neutralization of endogenous IL-1alpha using an anti-IL-1alpha antiserum inhibits the induction of I-309 transcripts in response to stimulation with immobilized IgG and LPS , and exogenous IL-1alpha or *induces* [I-309] transcripts in monocytes stimulated with immobilized IgG . Positive_regulation CCL1 TNF 11876523 918929 Chemokines are produced in a coordinated and sequential manner , with IL-8 and RANTES *induced* by during early stages , and MCP-1 , IP-10 , Mig , I-TAC , [I-309] and MDC induced by IFN-gamma during later stages . Positive_regulation CCL1 TNF 19302817 2064267 Using the AhR antagonist alpha-napthtoflavone , the translational inhibitor cycloheximide and anti-tumor necrosis factor alpha (TNFalpha) neutralizing antibodies , we demonstrated that Lp(a) mediated mRNA induction of [CCL1] occurs in an AhR independent manner and *requires* de novo protein synthesis of . Positive_regulation CCL1 TNF 19302817 2064285 These data suggest that Lp(a) triggered induction of [CCL1] expression is *mediated* by and subsequent activation of NF-kappaB , without AhR involvement . Positive_regulation CCL1 TNF 20383177 2255756 In the *presence* of , BPA treatment enhanced the expression of [CC chemokine ligand 1 (CCL1)] in DCs . Positive_regulation CCL11 EDN2 9758899 536329 [Eotaxin] significantly *induced* release in a dose dependent manner . Positive_regulation CCL11 IL1B 14670803 1210952 [Eotaxin] release *induced* by was unaffected by STAT6 antisense ODN ( p > 0.05 ) . Positive_regulation CCL11 MAP2K6 16755001 1571599 [Eotaxin-1/CCL11] production was *inhibited* by a p38 mitogen activated protein kinase (MAPK) inhibitor , SB203580 , but not by the ( MAPK/ERK kinase ) inhibitors , PD98059 and U0126 . Positive_regulation CCL11 TNF 10586089 571820 [Eotaxin] promoter activity was *increased* by ( 2.5-fold ) and IL-4 ( 1.5-fold ) , respectively . Positive_regulation CCL11 TNF 11919075 925999 [Eotaxin] was *induced* by or interleukin (IL)-4 and was drastically increased by their combination . Positive_regulation CCL11 TNF 16604092 1562638 Rosmarinic acid as a downstream inhibitor of IKK-beta in *induced* upregulation of [CCL11] and CCR3 . Positive_regulation CCL11 TNF 16604092 1562640 2. In order to determine the effects of rosmarinic acid on the *induced* upregulation of [CCL11] and CCR3 in human dermal fibroblasts , we performed an enzyme linked immunosorbent assay for CCL11 and a Western blot assay for CCR3 . Positive_regulation CCL11 TNF 16604092 1562642 The *induced* expression of [CCL11] and CCR3 genes was attenuated by rosmarinic acid . Positive_regulation CCL11 TNF 18714023 1950933 In this study , we describe a novel role for protein kinase C ( PKC ) betaIotaIota in augmenting NF-kappaB mediated *induced* transcription of the target gene [CCL11] in human airway smooth muscle cells by phosphorylating the HAT p/CAF . Positive_regulation CCL11 TNF 18714023 1950936 Furthermore , mouse embryonic fibroblasts from PKCbeta knockout mice showed markedly reduced *induced* [CCL11] expression and NF-kappaB reporter activity that was restored on PKCbetaII overexpression , suggesting a critical role for this pathway . Positive_regulation CCL11 TNF 23839108 2816080 EGCG prevented IL-1ß/ IL-4 or *mediated* [CCL11] production in a concentration dependent manner . Positive_regulation CCL13 IL1B 10934112 720412 In support of our in situ findings demonstrating MCP-4 expression in epithelial cells and mononuclear cells in vivo , we have found that [MCP-4] expression can be *induced* in these cells in vitro by tumor necrosis factor-alpha (TNF-alpha) and . Positive_regulation CCL13 IL1B 11597922 870315 IL-4 inhibited eotaxin and [MCP-4] mRNA expression *induced* by and tumor necrosis factor-alpha in PBMCs but did not significantly inhibit expression in epithelial cells . Positive_regulation CCL13 IL1B 11597922 870317 *induced* eotaxin and [MCP-4] protein production was also inhibited by IL-4 in PBMCs , whereas IL-4 enhanced eotaxin protein production in A549 cells . Positive_regulation CCL13 TNF 10553092 565542 Eotaxin and [MCP-4] mRNA expression *induced* by alone or in combination with IFN-gamma was near-maximal after 1 h , peaked at 4 and 8 h , respectively , remained unchanged up to 24 h , and was protein synthesis independent . Positive_regulation CCL13 TNF 10934112 720411 In support of our in situ findings demonstrating MCP-4 expression in epithelial cells and mononuclear cells in vivo , we have found that [MCP-4] expression can be *induced* in these cells in vitro by and interleukin-1beta (IL-1beta) . Positive_regulation CCL13 TNF 11597922 870314 IL-4 inhibited eotaxin and [MCP-4] mRNA expression *induced* by IL-1 beta and in PBMCs but did not significantly inhibit expression in epithelial cells . Positive_regulation CCL13 TNF 23007802 2837655 Interestingly , [CCL13] expression was positively *regulated* by ( TNF-a ) . Positive_regulation CCL15 TNF 11888507 920039 [LKN-1] also *induced* the transient expression of , IL-8 , and MCP-1 within 15 min of the treatment of the THP-1 cells . Positive_regulation CCL15 TNF 22092970 2534695 [CCL15] is constitutively expressed in human ASMC and is strongly *up-regulated* by . Positive_regulation CCL15 TNF 22092970 2534696 *induced* [CCL15] levels can be synergistically enhanced by the presence of IFN-? , at both the transcriptional and translation level . Positive_regulation CCL17 CCL20 20947098 2369226 [CCL17] and CCL20 were not *detected* in CSF in either of the groups , whereas serum level was significantly higher in remission than during relapse . Positive_regulation CCL17 CCL22 15466387 1305681 protein expression peaked at day 4 , but [CCL17] levels were not *increased* significantly at any time after egg challenge . Positive_regulation CCL17 CCL22 19715610 2133527 Previously , we have demonstrated the selective upregulation of the macrophage derived chemokine and the thymus activation *regulated* chemokine [CCL17] among chemokines , in a rat model of radiation pneumonitis/pulmonary fibrosis and preliminarily observed an increase in bronchoalveolar (BAL) fluid CCL22 levels of IPF patients . Positive_regulation CCL17 CCR4 24563252 2924617 Mutation of a single C-terminal residue K310 within a putative CCR4 antagonist binding site ablated *activation* of by [CCL17] , but not by CCL22 , despite having no effect on the binding of either ligand . Positive_regulation CCL17 CD40 11981828 938310 ligation of PB cells *induced* the mRNA expression of both CCL22 and [CCL17] . Positive_regulation CCL17 CD40 21054781 2469435 In contrast , LC-like cells released [CCL17] in *response* to ligation , irrespective of a prior treatment with TSLP . Positive_regulation CCL17 CD40LG 23686488 2796681 We found that IL-4 and are expressed by intratumoral TFH and *induce* production of [CCL17] and CCL22 by FL tumor cells . Positive_regulation CCL17 CHIA 18824549 1987883 Transfected and recombinant *induced* epithelial cell production of CCL2 , [CCL17] , and CXCL8 . Positive_regulation CCL17 CSF2 20693421 2312048 In vitro , IL-33 and are potent inducers of ST2L expression on eosinophils , and IL-33 *induced* the production of IL-13 , [CCL17] , and TGF-beta by eosinophils . Positive_regulation CCL17 EPHB2 20138154 2227169 Hirsutenone , dexamethasone , inhibitor or Bay 11-7085 ( an inhibitor of NF-kappaB activation ) *reduced* the lipopolysaccharide induced production of cytokines IL-1beta and IL-8 , and the chemokine [CCL17] . Positive_regulation CCL17 HNRNPF 12909129 1121884 Endogenous CCL17 and B7-DC mRNAs were increased similarly in IL-4 cultured but only [CCL17] was *induced* by LPS . Positive_regulation CCL17 HNRNPF 24123684 2863755 In vitro , TSLP *induced* CD11b ( high ) to express [CCL17] , to increase CCR7 mediated migration activity , and to drive Th2 differentiation of naive CD4 T cells . Positive_regulation CCL17 HNRNPH1 12909129 1121885 Endogenous CCL17 and B7-DC mRNAs were increased similarly in IL-4 cultured but only [CCL17] was *induced* by LPS . Positive_regulation CCL17 HNRNPH1 24123684 2863756 In vitro , TSLP *induced* CD11b ( high ) to express [CCL17] , to increase CCR7 mediated migration activity , and to drive Th2 differentiation of naive CD4 T cells . Positive_regulation CCL17 IFNG 16117790 1449199 Stimulation with tumor necrosis factor (TNF)alpha and synergistically induced thymus- and activation *regulated* chemokine ( TARC ) [/CCL17] production from HaCaT keratinocytes ( KC ) . Positive_regulation CCL17 IFNG 19576177 2111559 Keratinocytes , one of major cell types in the skin , can be *induced* by TNF-alpha and to express thymus- and activation regulated chemokine ( [TARC/CCL17] ) , which is considered to be a pivotal mediator in the inflammatory responses during the development of inflammatory skin diseases , such as atopic dermatitis ( AD ) . Positive_regulation CCL17 IFNG 20022349 2241195 In this study , we investigated whether [CCL17] and CCL28 transcription in cultured keratinocytes is *induced* by TNF-alpha , IL-1beta , or . Positive_regulation CCL17 IL13 15219001 1263896 In peripheral mononuclear cells from atopic donors , CCL22 and [CCL17] were *induced* by IL-4 and , further supporting the relationship between CCL22/CCL17 and Th2 cytokines . Positive_regulation CCL17 IL13 22365581 2606243 Dendritic cell and alveolar macrophage depletion protected mice from *induced* airway inflammation and CCL11 , CCL24 , CCL22 , and [CCL17] chemokine production . Positive_regulation CCL17 IL13 22365581 2606246 Preferential depletion of dendritic cells protected mice from *induced* airway inflammation and CCL22 and [CCL17] chemokine production but not from IL-13 induced CCL11 and CCL24 chemokine production . Positive_regulation CCL17 IL13 24704819 2938793 Both and IL-4 dose-dependently *induce* [CCL17] production from J774 mouse monocytic cells and CCL11 production from NIH3T3 mouse fibroblasts in the presence of TNFa . Positive_regulation CCL17 IL17A 17101734 1650851 Mechanistically , down modulated eosinophil-chemokine eotaxin ( CCL11 ) and thymus- and activation *regulated* [chemokine/CCL17] ( TARC ) in lungs in vivo and ex vivo upon antigen restimulation . Positive_regulation CCL17 IL1B 20022349 2241196 In this study , we investigated whether [CCL17] and CCL28 transcription in cultured keratinocytes is *induced* by TNF-alpha , , or IFN-gamma . Positive_regulation CCL17 IL33 20693421 2312047 In vitro , and GM-CSF are potent inducers of ST2L expression on eosinophils , and IL-33 *induced* the production of IL-13 , [CCL17] , and TGF-beta by eosinophils . Positive_regulation CCL17 IL33 23711854 2792851 *induced* the production of thymus and activation regulated [chemokine/CCL17] and macrophage derived chemokine/CCL22 and the activation of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 MAPK . Positive_regulation CCL17 IL4 15219001 1263897 In peripheral mononuclear cells from atopic donors , CCL22 and [CCL17] were *induced* by and IL-13 , further supporting the relationship between CCL22/CCL17 and Th2 cytokines . Positive_regulation CCL17 IL4 16810739 1591316 *induces* expression of [TARC/CCL17] via two STAT6 binding sites . Positive_regulation CCL17 IL4 16810739 1591318 We show here that [TARC/CCL17] is expressed by human T cells upon *stimulation* with . Positive_regulation CCL17 IL4 17134490 1661446 *induction* of the [CC chemokine TARC] ( CCL17 ) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter . Positive_regulation CCL17 IL4 18191727 1838909 *induced* activation of [CCL17] expression was recently demonstrated to result from two STAT6 motifs in the proximal promoter . Positive_regulation CCL17 IL4 19332534 2080445 induced CCL11 , CCL17 , CCL22 , and CCL26 mRNA , and ATRA *increased* the basal and IL4 stimulated expression of [CCL17] and CCL22 . Positive_regulation CCL17 IL4 23686488 2796682 We found that and CD40L are expressed by intratumoral TFH and *induce* production of [CCL17] and CCL22 by FL tumor cells . Positive_regulation CCL17 IL4 23686488 2796689 alone *induces* only [CCL17] but enhances stimulation by CD40L of both CCL17 and CCL22 . Positive_regulation CCL17 IL4 24704819 2938794 Both IL-13 and dose-dependently *induce* [CCL17] production from J774 mouse monocytic cells and CCL11 production from NIH3T3 mouse fibroblasts in the presence of TNFa . Positive_regulation CCL17 JAK2 22943853 2688082 Inhibitors of c-Raf-1 , p38 MAPK , and , *suppressed* the TNF-a/IFN-? induced production of [TARC/CCL17] , and phosphorylation of these signaling molecules were attenuated by spinasterol-Glc . Positive_regulation CCL17 JUN 18557811 1972039 Furthermore , a inhibitor , a phosphatidylinositol-3-kinase (PI3K) inhibitor and a nuclear factor kappa B (NF-kappa B) inhibitor *inhibited* [CCL17] production by HGFs . Positive_regulation CCL17 MAPK1 22943853 2688083 Inhibitors of c-Raf-1 , p38 , and JAK2 , *suppressed* the TNF-a/IFN-? induced production of [TARC/CCL17] , and phosphorylation of these signaling molecules were attenuated by spinasterol-Glc . Positive_regulation CCL17 MAPK1 23711854 2792853 IL-33 induced the production of thymus and activation regulated [chemokine/CCL17] and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 . Positive_regulation CCL17 MAPK10 22943853 2688084 Inhibitors of c-Raf-1 , p38 , and JAK2 , *suppressed* the TNF-a/IFN-? induced production of [TARC/CCL17] , and phosphorylation of these signaling molecules were attenuated by spinasterol-Glc . Positive_regulation CCL17 MAPK10 23711854 2792854 IL-33 induced the production of thymus and activation regulated [chemokine/CCL17] and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 . Positive_regulation CCL17 MAPK11 22943853 2688085 Inhibitors of c-Raf-1 , p38 , and JAK2 , *suppressed* the TNF-a/IFN-? induced production of [TARC/CCL17] , and phosphorylation of these signaling molecules were attenuated by spinasterol-Glc . Positive_regulation CCL17 MAPK11 23711854 2792855 IL-33 induced the production of thymus and activation regulated [chemokine/CCL17] and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 . Positive_regulation CCL17 MAPK12 22943853 2688086 Inhibitors of c-Raf-1 , p38 , and JAK2 , *suppressed* the TNF-a/IFN-? induced production of [TARC/CCL17] , and phosphorylation of these signaling molecules were attenuated by spinasterol-Glc . Positive_regulation CCL17 MAPK12 23711854 2792856 IL-33 induced the production of thymus and activation regulated [chemokine/CCL17] and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 . Positive_regulation CCL17 MAPK13 22943853 2688087 Inhibitors of c-Raf-1 , p38 , and JAK2 , *suppressed* the TNF-a/IFN-? induced production of [TARC/CCL17] , and phosphorylation of these signaling molecules were attenuated by spinasterol-Glc . Positive_regulation CCL17 MAPK13 23711854 2792857 IL-33 induced the production of thymus and activation regulated [chemokine/CCL17] and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 . Positive_regulation CCL17 MAPK14 22943853 2688088 Inhibitors of c-Raf-1 , p38 , and JAK2 , *suppressed* the TNF-a/IFN-? induced production of [TARC/CCL17] , and phosphorylation of these signaling molecules were attenuated by spinasterol-Glc . Positive_regulation CCL17 MAPK14 23711854 2792858 IL-33 induced the production of thymus and activation regulated [chemokine/CCL17] and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 . Positive_regulation CCL17 MAPK15 22943853 2688081 Inhibitors of c-Raf-1 , p38 , and JAK2 , *suppressed* the TNF-a/IFN-? induced production of [TARC/CCL17] , and phosphorylation of these signaling molecules were attenuated by spinasterol-Glc . Positive_regulation CCL17 MAPK15 23711854 2792852 IL-33 induced the production of thymus and activation regulated [chemokine/CCL17] and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 . Positive_regulation CCL17 MAPK3 22943853 2688089 Inhibitors of c-Raf-1 , p38 , and JAK2 , *suppressed* the TNF-a/IFN-? induced production of [TARC/CCL17] , and phosphorylation of these signaling molecules were attenuated by spinasterol-Glc . Positive_regulation CCL17 MAPK3 23711854 2792859 IL-33 induced the production of thymus and activation regulated [chemokine/CCL17] and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 . Positive_regulation CCL17 MAPK4 22943853 2688090 Inhibitors of c-Raf-1 , p38 , and JAK2 , *suppressed* the TNF-a/IFN-? induced production of [TARC/CCL17] , and phosphorylation of these signaling molecules were attenuated by spinasterol-Glc . Positive_regulation CCL17 MAPK4 23711854 2792860 IL-33 induced the production of thymus and activation regulated [chemokine/CCL17] and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 . Positive_regulation CCL17 MAPK6 22943853 2688091 Inhibitors of c-Raf-1 , p38 , and JAK2 , *suppressed* the TNF-a/IFN-? induced production of [TARC/CCL17] , and phosphorylation of these signaling molecules were attenuated by spinasterol-Glc . Positive_regulation CCL17 MAPK6 23711854 2792861 IL-33 induced the production of thymus and activation regulated [chemokine/CCL17] and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 . Positive_regulation CCL17 MAPK7 22943853 2688092 Inhibitors of c-Raf-1 , p38 , and JAK2 , *suppressed* the TNF-a/IFN-? induced production of [TARC/CCL17] , and phosphorylation of these signaling molecules were attenuated by spinasterol-Glc . Positive_regulation CCL17 MAPK7 23711854 2792862 IL-33 induced the production of thymus and activation regulated [chemokine/CCL17] and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 . Positive_regulation CCL17 MAPK8 22943853 2688093 Inhibitors of c-Raf-1 , p38 , and JAK2 , *suppressed* the TNF-a/IFN-? induced production of [TARC/CCL17] , and phosphorylation of these signaling molecules were attenuated by spinasterol-Glc . Positive_regulation CCL17 MAPK8 23711854 2792863 IL-33 induced the production of thymus and activation regulated [chemokine/CCL17] and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 . Positive_regulation CCL17 MAPK9 22943853 2688094 Inhibitors of c-Raf-1 , p38 , and JAK2 , *suppressed* the TNF-a/IFN-? induced production of [TARC/CCL17] , and phosphorylation of these signaling molecules were attenuated by spinasterol-Glc . Positive_regulation CCL17 MAPK9 23711854 2792864 IL-33 induced the production of thymus and activation regulated [chemokine/CCL17] and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 . Positive_regulation CCL17 NFKB1 18557811 1972040 Furthermore , a c-Jun NH2 terminal kinase (JNK) inhibitor , a phosphatidylinositol-3-kinase (PI3K) inhibitor and a inhibitor *inhibited* [CCL17] production by HGFs . Positive_regulation CCL17 PAEP 21905498 2478433 These results suggest that may *induce* TH2 cells in the skin through the production of [CCL17] by Langerhans cells and would explain the role of colonization by S aureus in patients with atopic dermatitis . Positive_regulation CCL17 PDCD1LG2 12909129 1121883 Endogenous CCL17 and mRNAs were increased similarly in IL-4 cultured DCs but only [CCL17] was *induced* by LPS . Positive_regulation CCL17 PDLIM7 14747532 1204348 EBV infection or stable expression of also *induced* [CCL17] and CCL22 in a B-cell line , BJAB . Positive_regulation CCL17 PDLIM7 14747532 1204350 Collectively , *induces* [CCL17] and CCL22 in EBV infected B cells via activation of NF-kappa B and probably ATF2 . Positive_regulation CCL17 PI3 18557811 1972041 Furthermore , a c-Jun NH2 terminal kinase (JNK) inhibitor , a inhibitor and a nuclear factor kappa B (NF-kappa B) inhibitor *inhibited* [CCL17] production by HGFs . Positive_regulation CCL17 POLDIP2 20837364 2368512 The present results suggest that TNF-a induced [CCL17] mRNA transcription in CPEK is positively *regulated* by but negatively controlled by ERK . Positive_regulation CCL17 PTBP1 12909129 1121886 Endogenous CCL17 and B7-DC mRNAs were increased similarly in IL-4 cultured but only [CCL17] was *induced* by LPS . Positive_regulation CCL17 PTBP1 24123684 2863757 In vitro , TSLP *induced* CD11b ( high ) to express [CCL17] , to increase CCR7 mediated migration activity , and to drive Th2 differentiation of naive CD4 T cells . Positive_regulation CCL17 PTBP2 12909129 1121882 Endogenous CCL17 and B7-DC mRNAs were increased similarly in IL-4 cultured but only [CCL17] was *induced* by LPS . Positive_regulation CCL17 PTBP2 24123684 2863753 In vitro , TSLP *induced* CD11b ( high ) to express [CCL17] , to increase CCR7 mediated migration activity , and to drive Th2 differentiation of naive CD4 T cells . Positive_regulation CCL17 RAF1 22943853 2688095 Inhibitors of , p38 MAPK , and JAK2 , *suppressed* the TNF-a/IFN-? induced production of [TARC/CCL17] , and phosphorylation of these signaling molecules were attenuated by spinasterol-Glc . Positive_regulation CCL17 RELA 18557811 1972042 Furthermore , a c-Jun NH2 terminal kinase (JNK) inhibitor , a phosphatidylinositol-3-kinase (PI3K) inhibitor and a inhibitor *inhibited* [CCL17] production by HGFs . Positive_regulation CCL17 STAT6 20393449 2240467 The following study investigates the *role* of the transcriptional activator in IL-4 dependant gene expression of [CCL17] in a Burkitt lymphoma cell line ( Namalwa ) . Positive_regulation CCL17 TGFB1 12413771 1010985 *mediated* regulation of thymus and activation regulated chemokine ( [TARC/CCL17] ) synthesis and secretion by HaCaT cells co-stimulated with TNF-alpha and IFN-gamma . Positive_regulation CCL17 TNF 16117790 1449198 Stimulation with and interferon (IFN)gamma synergistically induced thymus- and activation *regulated* chemokine ( TARC ) [/CCL17] production from HaCaT keratinocytes ( KC ) . Positive_regulation CCL17 TNF 19576177 2111558 Keratinocytes , one of major cell types in the skin , can be *induced* by and IFN-gamma to express thymus- and activation regulated chemokine ( [TARC/CCL17] ) , which is considered to be a pivotal mediator in the inflammatory responses during the development of inflammatory skin diseases , such as atopic dermatitis ( AD ) . Positive_regulation CCL17 TNF 20022349 2241194 In this study , we investigated whether [CCL17] and CCL28 transcription in cultured keratinocytes is *induced* by , IL-1beta , or IFN-gamma . Positive_regulation CCL17 TNF 20022349 2241206 It was found that [CCL17] mRNA transcription is *augmented* by only , whereas the CCL28 mRNA level could be increased by TNF-alpha , IL-1beta , or IFN-gamma . Positive_regulation CCL17 TNF 20837364 2368507 Identification of the signaling pathway of *induced* [CCL17/TARC] transcription in a canine keratinocyte cell line . Positive_regulation CCL17 TNF 20837364 2368508 The aim of the present study is to clarify the regulatory mechanism of *induced* [CCL17] mRNA transcription in canine keratinocytes leading to the development of a chemokine targeted therapy for cAD . Positive_regulation CCL17 TNF 20837364 2368511 The present results suggest that *induced* [CCL17] mRNA transcription in CPEK is positively regulated by p38 but negatively controlled by ERK . Positive_regulation CCL17 TNF 21116791 2350932 Furthermore , Carbon monoxide , but not other end products of HO-1 activity , also suppressed IFN-? and *induced* [TARC/CCL17] and MDC/CCL22 production . Positive_regulation CCL17 TNF 22943853 2688078 In present study , we investigated the effect of spinasterol-Glc on production of [TARC/CCL17] *induced* by and IFN-? in human HaCaT keratinocytes . Positive_regulation CCL17 TNF 22943853 2688079 Spinasterol-Glc inhibited the mRNA and protein expression of [TARC/CCL17] *induced* by in a dose dependent manner . Positive_regulation CCL17 TNF 22943853 2688080 Inhibitors of c-Raf-1 , p38 MAPK , and JAK2 , suppressed the *induced* production of [TARC/CCL17] , and phosphorylation of these signaling molecules were attenuated by spinasterol-Glc . Positive_regulation CCL17 TNF 24704449 2935363 We found that ( + ) -nootkatone inhibited the *induced* expression of [TARC/CCL17] and MDC/CCL22 mRNA in HaCaT cells . Positive_regulation CCL17 TNF 24704449 2935403 Furthermore , we showed that PKC? and p38 MAPK contributed to the inhibition of *induced* [TARC/CCL17] and MDC/CCL22 expression by blocking I?Ba degradation in HaCaT cells . Positive_regulation CCL17 TNF 24704449 2935406 Taken together , these results suggest that ( + ) -nootkatone may suppress *induced* [TARC/CCL17] and MDC/CCL22 expression in HaCaT cells by inhibiting of PKC? and p38 MAPK signaling pathways that lead to activation of NF-?B . Positive_regulation CCL17 TSLP 23576878 2768504 We report here that beyond simply expressing the receptor , epithelial cells are capable of dynamically regulating TSLPR in response to the same inflammatory cues that drive the production of TSLP , and that epithelial cells produce [chemokine C-C motif ligand 17] , a T helper type 2-associated chemokine , in *response* to stimulation with . Positive_regulation CCL17 TSLP 23639975 2848770 Our data showed that UVB induced might *increase* secretion of the T-helper type 2-attracting [chemokine (c-c motif) ligand 17] by human dendritic cells . Positive_regulation CCL17 TSLP 24123684 2863754 In vitro , *induced* CD11b ( high ) DCs to express [CCL17] , to increase CCR7 mediated migration activity , and to drive Th2 differentiation of naive CD4 T cells . Positive_regulation CCL17 TSLP 24486456 2918541 *promoted* the expression of CD40 , CD80 , OX40 ligand (OX40L) , IL-13 and [CCL17] by DCs . Positive_regulation CCL17 UVRAG 18937546 1994664 *induces* CD4+ T-cell chemoattractant [TARC/CCL17] in human epithelial cells . Positive_regulation CCL18 TLR7 19255934 2175696 The aim of our study was to determine whether mediated stimulation of monocytes and dendritic cells (DCs) *contributes* to the higher levels of [CCL18] in SSc . Positive_regulation CCL19 TLR7 20498301 2307696 In contrast to the PGE ( 2 ) -matured DCs , DCs matured in the *presence* of ligands and interferons produce high levels of both [CCL19] and CCR7 mRNA/protein , but show selectively reduced expression of surface CCR7 , which is compensated after DC removal from the CCL19-rich maturation environment . Positive_regulation CCL2 ANGPT1 20571857 2315880 Inhibition of p38 MAP kinase , a signaling molecule required for mural cell recruitment , blocks *induced* [MCP-1] expression . Positive_regulation CCL2 ARSA 18077625 1868181 Therefore , <5-ASA> prevents irradiation *induced* inflammatory processes as well as expression of tumor necrosis factor alpha , [monocyte chemotactic protein-1] , inducible nitric-oxide synthase , and macrophage infiltration . Positive_regulation CCL2 CD14 12410798 1010658 *mediated* induction of interleukin-8 and [monocyte chemoattractant protein-1] by a heat-resistant constituent of Porphyromonas gingivalis in endothelial cells . Positive_regulation CCL2 CD14 15863460 1439681 Low concentrations ( ng/ml ) of Escherichia coli LPS , the prototypical TLR4 agonist , markedly stimulated extracellular regulated kinase 1/2 ( ERK1/2 ) activity , induced release of [monocyte-chemoattractant protein-1] ( MCP-1 ) and interleukin (IL)-6 , and stimulated IL-1alpha expression in human aortic SMC , and exogenous *enhanced* these effects . Positive_regulation CCL2 CD14 19920349 2171817 In vitro , coculture of monocytes and aortic adventitial fibroblasts produced [MCP-1-] and IL-6 enriched conditioned medium that promoted differentiation of monocytes into macrophages , *induced* and CD11b upregulation , and induced MCP-1 and MMP-9 expression . Positive_regulation CCL2 CLU 24662749 2930605 The results showed that LPS significantly increased MCP-1 and TLR4 expression and MCP-1 secretion in 3T3-L1 adipocytes , and that the [MCP-1] expression was *blocked* by a TLR4 inhibitor ( ) . Positive_regulation CCL2 CTGF 16408113 1513389 The present studies investigate the regulatory *role* of in the production of fractalkine , [monocyte chemoattractant protein-1] ( MCP-1 ) , and RANTES ( regulated upon activation , normal T cell expressed and secreted ) in cultured mesangial cells of rats , and the modulatory effects of lipoxin A ( 4 ) ( LXA ( 4 ) ) on actions of CTGF . Positive_regulation CCL2 CTGF 16408113 1513467 *enhanced* the mRNA expression and protein release of fractalkine , [MCP-1] , and RANTES , the expression of phospho ( P ) -p42/44 mitogen activated protein kinase (MAPK) , P-phosphoinositide 3-kinase (PI3-K) , P-Akt , and activity of nuclear factor-kappaB (NF-kappaB) in mesangial cells . Positive_regulation CCL2 CTGF 16408113 1513545 In conclusion , these results demonstrate that *induces* production of fractalkine , [MCP-1] , and RANTES via the p42/44 MAPK- , PI3-K/Akt- , and NF-kappaB dependent signal pathway , and LXA ( 4 ) downregulates the above effects of CTGF on rat mesangial cells . Positive_regulation CCL2 CTGF 19378419 2007966 *enhanced* the mRNA expressions and protein release of fractalkine , [MCP-1] and RANTES , and the expressions of phosphorylated ERK1/2 , PI3-K and PKB , and activities of NF-KB . Positive_regulation CCL2 CTGF 19378419 2007968 These results demonstrated that *induces* production of fractalkine , [MCP-1] and RANTES via ERK1/2 and PI3-K/PKB/NF-kappaB dependent signal pathway mediated by cell surface heparin sulfate proteoglycans and the tyrosine kinase receptor TrkA in human mesangial cells . Positive_regulation CCL2 CTGF 23274856 2758050 *induces* [monocyte chemoattractant protein-1] expression to enhance monocyte migration in human synovial fibroblasts . Positive_regulation CCL2 EPHB2 12517735 1070988 In conclusion , these findings indicate that signaling is *involved* in BSA induced [MCP-1] expression in mProx cells . Positive_regulation CCL2 EPHB2 12582006 1084899 Inhibitors of , JNK , and p38 *reduced* LC-induced IL-6 and [MCP-1] production . Positive_regulation CCL2 EPHB2 12743010 1093440 Inhibition of p38 ( with SB 203580 ) , 44/42 ( with UO126 or PD 98059 ) , or COX-2 ( with NS398 ) each significantly *suppressed* uric acid induced [MCP-1] expression at 24 hours , implicating these pathways in the response to uric acid . Positive_regulation CCL2 EPHB2 12854631 1110208 We conclude that p38 MAPK , JNK kinase , and NF-kappaB are *involved* in the IL-1beta induced eotaxin , [MCP-1] , and MCP-3 expression and release in HASMC . Positive_regulation CCL2 EPHB2 16436136 1516401 Using various selective inhibitors for signaling molecules , we found that the inductions of IL-8 , [MCP-1] , and I-309 were *mediated* by either SCF activated or TNF-alpha activated p38 MAPK , while the induction of IP-10 by TNF-alpha was mediated by both activated p38 MAPK and NF-kappaB . Positive_regulation CCL2 EPHB2 16792687 1578823 Inhibition of p38 MAPK , and JAK-2 activities by pretreating the cells with their corresponding inhibitors SB203580 , PD98059 and AG490 , respectively , significantly *suppressed* IL-4- and IL-13 induced [MCP-1] production in BEAS-2B cells . Positive_regulation CCL2 EPHB2 17460254 1731569 The MMC related IL-8 and [MCP-1] expression was *inhibited* by both a p38 inhibitor ( SB203580 ) and an inhibitor ( PD98059 ) . Positive_regulation CCL2 EPHB2 17627770 1816028 Selective inhibitors of p38 MAPK ( SB203580 ) , ( PD98059 ) , and JNK ( SP600125 ) could differentially *inhibit* the production of EGF , VEGF and [CCL2] , thereby suggesting a role for MAPKs in IL-31 functions . Positive_regulation CCL2 EPHB2 18656701 1942675 Selective inhibitors of p38 MAPK ( SB203580 ) , JNK ( SP600125 ) and ( PD98059 ) could *suppress* TNF-alpha induced [CCL2] and ICAM-1 expression , while only p38 MAPK and ERK inhibitors could suppress TNF-alpha induced VCAM-1 expression . Positive_regulation CCL2 EPHB2 19125410 2053752 These results demonstrate that astrocytic [MCP-1] production induced by P2 purinoceptor stimulation is reciprocally *regulated* by and p38 MAP kinases in the organotypic slice cultures . Positive_regulation CCL2 EPHB2 19429670 2106898 The [MCP-1] mRNA expression induced by TNF-alpha and co-stimulation with Ang II was *inhibited* by either inhibitor , p38MAPK inhibitor or NF-kappaB inhibitor . Positive_regulation CCL2 EPHB2 19573621 2136738 Such oxLDL elicited foamy-like phenotype was a pertussis toxin-sensitive process that depended on a paracrine activity of endogenous [MCP-1/CCL2] and *activation* of . Positive_regulation CCL2 EPHB2 19766691 2195522 Curcumin *inhibits* phorbol myristate acetate ( PMA ) -induced [MCP-1] expression by inhibiting and NF-kappaB transcriptional activity . Positive_regulation CCL2 EPHB2 20384770 2267098 Sustained activation of signaling in astrocytes is *critical* for neuronal injury induced [monocyte chemoattractant protein-1] production in rat corticostriatal slice cultures . Positive_regulation CCL2 EPHB2 20384770 2267099 In this case , MCP-1 production was not suppressed , suggesting that activation of neuronal is not *necessary* for [MCP-1] production . Positive_regulation CCL2 EPHB2 22736938 2621648 IL-6 expression was mediated by the p38 , ERK , JNK pathways , whereas [MCP-1] expression was *mediated* by and JNK , but not by p38 , in palmitate treated orbital fibroblasts . Positive_regulation CCL2 F2R 11468165 840837 In addition , SB203580 decreased IL-8 and [MCP-1] production *induced* by the agonist peptide ( TRAP ) , suggesting functional links between the thrombin G protein coupled receptor and the p38 MAPK pathway . Positive_regulation CCL2 F2R 18353977 1912632 We further demonstrate that these effects are mediated via the cooperation between ERK1/2 and Rho kinase signaling pathways : a calcium independent protein kinase C ( PKC ) , c-Raf , and ERK1/2 pathway was found to mediate *induced* [CCL2] gene transcription , whereas a phospholipase C , calcium dependent PKC , and Rho kinase pathway influences CCL2 protein release . Positive_regulation CCL2 F2R 19060230 2035514 The ability of to *induce* [CCL2] production by lung epithelial cells was also examined in vitro . Positive_regulation CCL2 F2R 20570895 2290453 We found that activation *induces* the secretion of several angiogenic factors from ovarian carcinoma cells , most prominently interleukin (IL)-8 , growth regulated oncogene-alpha ( GRO-alpha ) , and [monocyte chemoattractant protein-1] . Positive_regulation CCL2 F2R 21760880 2456280 Through the use of PAR-1 and PAR-2 neutralizing antibodies , it was determined that is *essential* for GrK induced IL-6 , IL-8 and [MCP-1] release . Positive_regulation CCL2 F2R 8163952 254576 Moreover , a human activating peptide ( TRAP1-7 ) also *stimulates* [MCP-1] production . Positive_regulation CCL2 F3 9353321 461502 is *induced* by [monocyte chemoattractant protein-1] in human aortic smooth muscle and THP-1 cells . Positive_regulation CCL2 FAS 11595074 870101 IFN-gamma pretreatment and Ag stimulation synergistically *induced* not only apoptosis but also IL-8 and [MCP-1] secretion . Positive_regulation CCL2 FAS 12402381 1009526 Conclusively , TGF-beta2 , IL-8 and [MCP-1] were overexpressed in HBV associated hepatoma cells , and the expressions of chemokines were not *increased* by ligation in human hepatoma cells . Positive_regulation CCL2 FAS 12629330 1067354 Fas neutralizing agent ( Fas-Fc ) suppressed the *mediated* secretions of IL-8 and [MCP-1] ( P < 0.01 ) both as well as the Fas mediated apoptosis . Positive_regulation CCL2 FAS 12629330 1067356 On the other hand , whereas Z-IETD-FMK suppressed apoptosis , the inhibitor enhanced the *mediated* secretions of both IL-8 and [MCP-1] beyond the value of the Fas stimulation alone ( P < 0.01 ) , suggesting an enhanced signalling for the chemokine expression . Positive_regulation CCL2 FAS 12946945 1143212 and Fas associated death domain protein *regulate* [monocyte chemoattractant protein-1] expression by human smooth muscle cells through caspase- and calpain dependent release of interleukin-1alpha . Positive_regulation CCL2 FAS 12946945 1143216 In this study , we demonstrate that *induced* [MCP-1] upregulation is driven by an autocrine/paracrine signaling loop in which interleukin (IL)-1alpha synthesis and release are activated through caspase- and calpain dependent processes . Positive_regulation CCL2 FAS 16316466 1493948 When compared to WT , mutant astrocytes displayed an overall increased constitutive gelatinase expression and were less responsive to *mediated* upregulation of MMP-9 , of [monocyte chemoattractant protein-1] ( MCP-1 ) and of intercellular cell adhesion molecule-1 ( ICAM-1 ) , all markers of astrocyte inflammatory response . Positive_regulation CCL2 FAS 17239146 1690493 *mediated* upregulation of vascular endothelial growth factor and [monocyte chemoattractant protein-1] expression in cultured dermal fibroblasts : role in the inflammatory response . Positive_regulation CCL2 FAS 20926603 2375719 In contrast , IL-6 , [MCP-1] and RANTES were not *regulated* by . Positive_regulation CCL2 FAS 23434371 2760123 *induced* production of [MCP-1] and IL-8 promoted chemotaxis of phagocytes toward apoptotic cells , suggesting that these factors serve as `` find-me '' signals in this context . Positive_regulation CCL2 FOXQ1 24005989 2916088 induced VersicanV1 expression *promoted* the secretion of [chemokine (C-C motif) ligand 2] ( CCL2 ) from HCC cells . Positive_regulation CCL2 IL1B 10089132 599999 The mitogen activated protein kinase p38 is necesssary for *induced* [monocyte chemoattractant protein 1] expression by human mesangial cells . Positive_regulation CCL2 IL1B 10089132 600000 This study investigated the role of the MAP kinases p38 and ERK2 in *mediated* expression of the chemokine [MCP-1] by human mesangial cells . Positive_regulation CCL2 IL1B 10089132 600016 These data indicate that p38 kinase is necessary for the *induction* of [MCP-1] expression by , but is not involved at the level of cytoplasmic activation of NF-kappaB . Positive_regulation CCL2 IL1B 10089132 600017 In contrast , ERK2 does not mediate *induced* [MCP-1] gene expression . Positive_regulation CCL2 IL1B 10372996 622124 It has been shown in this and other laboratories that and tumor necrosis factor-alpha (TNF-alpha) are potent *inducers* of HRPE IL-8 and [MCP-1] secretion . Positive_regulation CCL2 IL1B 10372996 622130 and TNF-alpha induced dose dependent *increases* in HRPE IL-8 and [MCP-1] secretion with maximal stimulation observed at 2-5 ng/ml . IL-4 alone ( 100 ng/ml ) resulted in a slight increase of MCP-1 and IL-8 secretion . Positive_regulation CCL2 IL1B 10372996 622140 HRPE IL-8 and [MCP-1] gene expression and protein production are *stimulated* by or TNF-alpha through pathways differentially modulated by IL-4 and GM-CSF . Positive_regulation CCL2 IL1B 10413089 630923 In human vascular endothelial cells , and tumor necrosis factor-alpha *induced* endogenous [monocyte chemoattractant protein-1] protein secretion , mRNA expression and promoter activity . Positive_regulation CCL2 IL1B 10540157 563256 In contrast , strongly *induced* [MCP-1] secretion preferentially into the basal compartment of all RPE monolayers tested . Positive_regulation CCL2 IL1B 10559516 566644 However , *induced* productions of both [MCP-1] and IL-8 were dose-dependently suppressed by enrichment of cells with vitamin E. Vitamin E , at the doses used , did not significantly change the spontaneous production but dose-dependently inhibited the IL-1beta induced production of inflammatory cytokine IL-6 . Positive_regulation CCL2 IL1B 10580798 570120 However , 100 u/ml *induced* greater stimulation of both IL-8 and [MCP-1] secretion in HCEC ( 50 and 20 times above controls , respectively ) than in FHAS ( three and two times above controls , respectively ) . Positive_regulation CCL2 IL1B 10741905 680020 Both IL-1alpha and *induced* ICAM-1 expression and IL-8 and [MCP-1] production at lower doses than TNF alpha or TNF beta . Positive_regulation CCL2 IL1B 10756077 682862 *induced* expression of [monocyte chemotactic protein-1] in the rabbit retina : an in situ and immunohistochemical study . Positive_regulation CCL2 IL1B 10762077 683365 In addition , treatment with IFN-gamma or IL-4 enhanced *stimulated* [MCP-1] mRNA production and protein secretion . Positive_regulation CCL2 IL1B 10871649 708202 The *induced* [MCP-1] expression was even higher following pretreatment of cells with both oestradiol ( 10 ( -9 ) mol/l ) and progesterone ( 5x10 ( -8 ) mol/l ) . Positive_regulation CCL2 IL1B 10880246 709109 On the other hand , [JE/MCP-1] mRNA expression was detected only in non-parenchymal cells in *response* to TNF-alpha and , but not in response to IFN-gamma . Positive_regulation CCL2 IL1B 10881930 709224 The addition of and tumor necrosis factor (TNF)-alpha strongly *enhanced* IL-8 , [MCP-1] , and RANTES secretion ; Positive_regulation CCL2 IL1B 10889171 710417 IL-8 and [MCP-1] secretion was rapidly *induced* by both and tumor necrosis factor (TNF)-alpha . Positive_regulation CCL2 IL1B 11317664 806661 To investigate this issue , we analysed the signal transduction for *induced* [MCP-1] expression in rat beta cells and in vitro MCP-1 mRNA expression and protein release by human islets as well as in vivo islet MCP-1 mRNA expression in prediabetic non-obese diabetic mice . Positive_regulation CCL2 IL1B 11317664 806662 *induced* [MCP-1] mRNA expression in rat beta cells , with a maximum induction after 6 h . Positive_regulation CCL2 IL1B 11317664 806664 *induced* both MCP-1 mRNA expression and a threefold increase in medium [MCP-1] protein accumulation in human islet cells . Positive_regulation CCL2 IL1B 11330569 808144 After 24 hours , cell viability was assessed with the MTT assay , and *stimulated* [monocyte chemotactic protein-1 (MCP-1)] release with specific immunoassay . Positive_regulation CCL2 IL1B 11376856 820056 *upregulates* expression of the chemokine monocyte chemoattractant protein-1 ( [MCP-1] ) in many experimental models . Positive_regulation CCL2 IL1B 11461938 839108 Treatment of mesangial cells with prostaglandin J ( 2 ) and 15-deoxy-Delta ( 12,14 ) -prostaglandin J ( 2 ) blocked *induced* [monocyte chemoattractant protein-1] mRNA expression and protein production . Positive_regulation CCL2 IL1B 11557268 861283 Tranilast inhibits *induced* [monocyte chemoattractant protein-1] expression in rat mesangial cells . Positive_regulation CCL2 IL1B 11557268 861284 Tranilast inhibited *induced* [MCP-1] secretion and mRNA expression in a concentration dependent manner . Positive_regulation CCL2 IL1B 11673556 872876 On the other hand , [CCL2] , CCL5 , and CXCL12 were expressed on RA FLS , and their production was *regulated* by TNF-alpha , , and TGF-beta1 . Positive_regulation CCL2 IL1B 11937582 928270 Simultaneous addition of either monoclonal aCL or APS-IgG with IL-1beta resulted in synergistic increase in MCP-1 production , whereas the addition of control IgG lacking aCL activity did not alter *induced* levels of [MCP-1] . Positive_regulation CCL2 IL1B 11989790 936370 Our results show that pleural fluid isolated human fibroblasts release IL-8 and [MCP-1] upon *stimulation* with , TNF-alpha , and LPS in both a concentration- and time dependent manner . Positive_regulation CCL2 IL1B 11989790 936373 *induced* the maximum release of IL-8 ( 800-fold ) and [MCP-1] ( 164-fold ) , as compared to the controls . Positive_regulation CCL2 IL1B 12195705 981754 Furthermore , overexpression of kinase-inactive IKK-beta KA , as well as NIKKA , inhibited platelet- or *induced* kappa B- , [MCP-1-] or VCAM-1 dependent transcription . Positive_regulation CCL2 IL1B 12399621 1009116 Exogenous nitric oxide inhibits tumor necrosis factor-alpha- or *induced* [monocyte chemoattractant protein-1] expression in human mesangial cells . Positive_regulation CCL2 IL1B 12399621 1009119 SIN-1 inhibited TNF-alpha- or *induced* [MCP-1] mRNA expression in a dose dependent manner and also suppressed the MCP-1 protein expression . Positive_regulation CCL2 IL1B 12446609 1017808 In contrast , exogenous corticosterone abolished the effects of ketorolac on *induced* COX-2 and [monocyte chemoattractant protein-1] gene expression in the cerebral endothelium . Positive_regulation CCL2 IL1B 12498315 1026318 *induced* expression of intercellular adhesion molecule-1 and [monocyte chemoattractant protein-1] , both of which were abolished in the presence of pyrrolidine dithiocarbamate , a specific inhibitor of nuclear factor-kappaB activation . Positive_regulation CCL2 IL1B 12498315 1026320 *induced* [monocyte chemoattractant protein-1] was partially inhibited by specific inhibitors of MAP kinase kinase ( U0126 ) and of p38 MAP kinase ( SB203580 ) whereas intercellular adhesion molecule-1 expression was not altered by the inhibitors . Positive_regulation CCL2 IL1B 12540607 1050615 Transient transfections with luciferase-reporter constructs identified an interleukin (IL)-1beta-responsive enhancer region between -2,180 bp and -2,478 bp. Mutation of either of the two nuclear factor (NF)-kappaB sites present in this region abrogated *induced* [MCP-1] promoter activity . Positive_regulation CCL2 IL1B 12540607 1050616 Blocking of NF-kappaB activation in cytokine exposed primary beta-cells by an adenovirus overexpressing a nondegradable form of IkappaBalpha or by pyrrolidine dithiocarbamate decreased *induced* [MCP-1] mRNA expression . Positive_regulation CCL2 IL1B 12569227 1057223 Plasma interleukin (IL)-6 , IL-8 , IL-10 , granulocyte colony stimulating factor ( G-CSF ) , macrophage CSF (M-CSF) , and [monocyte chemotactic protein 1 (MCP-1)] increased significantly after the race , and urine , IL-6 , G-CSF , M-CSF , and MCP-1 *increased* significantly . Positive_regulation CCL2 IL1B 12594282 1060884 Bone morphogenetic protein-7 inhibits constitutive and *induced* [monocyte chemoattractant protein-1] expression in human mesangial cells : role for JNK/AP-1 pathway . Positive_regulation CCL2 IL1B 12594282 1060887 BMP- 7 significantly inhibited constitutive and *induced* [MCP-1] protein production and MCP-1 mRNA expression by mesangial cells in a time- and concentration dependent manner . Positive_regulation CCL2 IL1B 12594282 1060889 We examined the role of transcription factors NF-kappa B and AP-1 in BMP-7 inhibition of *induced* [MCP-1] expression . Positive_regulation CCL2 IL1B 12594282 1060892 IL-1 beta increased NF-kappa B and AP-1 activity and both transcription factors mediated *induced* [MCP-1] expression in mesangial cells . Positive_regulation CCL2 IL1B 12594282 1060906 These data suggest that BMP-7 inhibits constitutive and *induced* [MCP-1] expression in human mesangial cells partly by inhibiting c-Jun N-terminal kinase activity and subsequent AP-1 activity , and provide new insight into the therapeutic potential of BMP-7 in the inflammatory renal diseases . Positive_regulation CCL2 IL1B 12854631 1110209 We conclude that p38 MAPK , JNK kinase , ERK and NF-kappaB are involved in the *induced* eotaxin , [MCP-1] , and MCP-3 expression and release in HASMC . Positive_regulation CCL2 IL1B 12882449 1116297 The present study demonstrated that N-acetylcysteine inhibits the *induced* eotaxin and [monocyte chemotactic protein 1] expression and production due to a decreased activation of p38 mitogen activated protein kinase . Positive_regulation CCL2 IL1B 12952251 1137411 Prostaglandin E2 , known as an activator of the prostanoid receptors EP2 and EP4 , which are positively coupled to adenylyl cyclase , also decreased the *induced* eotaxin and [MCP-1] production by 57+/-17 and 53+/-4 % , respectively . Positive_regulation CCL2 IL1B 12952251 1137425 This study shows that an increase in intracellular cyclic adenosine monophosphate concentration may decrease the *induced* eotaxin and [monocyte chemotactic protein-1] expression and production . Positive_regulation CCL2 IL1B 14652683 1173704 The decrease in MCP-1 expression by hypoxia was mimicked by cobalt chloride in unstimulated RASF with no effect on *activated* [MCP-1] , suggesting differences in the signaling mechanisms . Positive_regulation CCL2 IL1B 14960322 1208540 At these concentrations , LY29 , but not WM , significantly inhibited constitutive and *induced* [MCP-1] expression at both protein and mRNA levels . Positive_regulation CCL2 IL1B 15039285 1265150 Compared with free form , fibrinogen bound *stimulated* increased activation of endothelial cell nuclear factor kappaB (NF-kappaB) , [monocyte chemoattractant protein-1] ( MCP-1 ) secretion , and nitric oxide ( NO ) synthesis . Positive_regulation CCL2 IL1B 15161854 1252954 The IC ( 50 ) for inhibition of [MCP-1] secretion *induced* by , TNF-alpha , and hRPE-monocyte binding was 16 , 12 , and less than 3 micro M , respectively . Positive_regulation CCL2 IL1B 15191916 1280934 The *induction* of IL-13 and [MCP-1] gene expression by was accompanied by the activation of IL-1 receptor associated kinase and translocation of the transcription factor , nuclear factor (NF) kappaB into the nucleus . Positive_regulation CCL2 IL1B 15191916 1280936 Accordingly , Bay-11 7082 , an inhibitor of NF-kappaB activation , inhibited *induced* IL-13 and [MCP-1] expression . Positive_regulation CCL2 IL1B 15298980 1322234 However , hCG has no effect on either basal or *mediated* [MCP-1] level . Positive_regulation CCL2 IL1B 15361371 1293700 EP2/EP4 signalling inhibits [monocyte chemoattractant protein-1] production *induced* by in synovial fibroblasts . Positive_regulation CCL2 IL1B 15665043 1402413 Consistent with the increase in IL-1R1 expression , OSM markedly augmented *induced* VEGF , [MCP-1] , and IL-6 release . Positive_regulation CCL2 IL1B 15908470 1451821 IL-1beta increased the production of MCP-1 by human umbilical vein endothelial cells from undetectable levels to approximately 900 pg/ml at 24 h. EtOH dose-dependently inhibited *stimulated* [MCP-1] secretion as determined by ELISA : 25 +/- 1 % , 35 +/- 7 % , and 65 +/- 5 % inhibition for 1 , 10 , and 100 mM EtOH , respectively , concomitant with inhibition of monocyte adhesion to activated endothelial cells . Positive_regulation CCL2 IL1B 15908470 1451822 Similarly , EtOH dose-dependently inhibited *stimulated* [MCP-1] mRNA expression . Positive_regulation CCL2 IL1B 16055671 1466208 Both differentiated and dedifferentiated type II cells secreted MIP-2 , [MCP-1] , and CINC-2 in *response* to a cytokine mixture of IL-1beta , TNF-alpha , and IFN-gamma or to alone . Positive_regulation CCL2 IL1B 16085045 1443030 Levels of IR [MCP-1] increased in myometrial cultures in *response* to . Positive_regulation CCL2 IL1B 16239643 1508320 Both cell phenotypes secreted MIP-2 and [MCP-1] in *response* to or lipopolysaccharide , but there was no priming or synergy with ozone . Positive_regulation CCL2 IL1B 16339837 1539628 Nrf2 also inhibited *induced* [MCP-1] gene expression in human mesangial cells . Positive_regulation CCL2 IL1B 16354624 1492629 *stimulated* IL-6 , IL-8 , and [MCP-1] mRNA expression and protein levels . Positive_regulation CCL2 IL1B 16391493 1560931 These findings indicate that berberine dose-dependently inhibited the expression of IL-8 and [MCP-1] *induced* by or TNF-alpha . Positive_regulation CCL2 IL1B 16597919 1589475 Calcitonin gene related peptide inhibits *induced* endogenous [monocyte chemoattractant protein-1] secretion in type II alveolar epithelial cells . Positive_regulation CCL2 IL1B 16597919 1589479 However , exogenous hCGRP ( 10-100 nM ) suppressed IL-1beta evoked MCP-1 secretion in MCP-1 promoter activity , and CGRP gene stably transfected cell clones significantly inhibited both the mRNA and protein levels of [MCP-1] *induced* by . Positive_regulation CCL2 IL1B 16597919 1589481 These data imply that AEII derived CGRP suppressed *induced* [MCP-1] secretion in an autocrine/paracrine mode . Positive_regulation CCL2 IL1B 16597919 1589487 We previously showed that the CGRP inhibitory effect was mediated by elevated intracellular cAMP and show here that analogs of cAMP , 8-bromoadenosine 3',5'-cyclic monophosphothioate and the Sp isomer of adenosine 3',5'-cyclic monophosphothioate , mimicked the CGRP suppressive effect on *induced* ROS formation , NF-kappaB activation , and [MCP-1] secretion . Positive_regulation CCL2 IL1B 16601113 1568695 Overexpression of GSK-3beta in endothelial cells , in contrast , significantly inhibited ( by 70 % , p < 0.01 ) both TNF-alpha and *induced* expression of IL-6 , [MCP-1] , and vascular cell adhesion molecule-1 . Positive_regulation CCL2 IL1B 16601138 1568718 The effects of adiponectin on *induced* secretion of IL-6 , IL-8 , and [monocyte chemoattractant protein 1] from cultured ESCs were determined using specific ELISAs . Positive_regulation CCL2 IL1B 16601138 1568724 Adiponectin decreased *induced* secretion of IL-6 , IL-8 , and [monocyte chemoattractant protein 1] from ESCs . Positive_regulation CCL2 IL1B 16636588 1583083 Silymarin dose-dependently inhibited the TNF-alpha- or induced NF-kappaB *activation* and [MCP-1] expression . Positive_regulation CCL2 IL1B 16849996 1600372 Likewise , in vitro study revealed that stimulation of tubular epithelial cells by and/or H2O2 sequentially *induced* KC , MIP-1alpha , and [MCP-1] in both protein and messenger RNA levels , which is consistent with in vivo results . Positive_regulation CCL2 IL1B 16869002 1607357 Treatment with EGCG at 10 microM or 20 microM significantly inhibited *induced* ENA-78 , RANTES , and GROalpha , but not [MCP-1] production in a concentration dependent manner . Positive_regulation CCL2 IL1B 17015748 1629888 *induced* increased mRNA levels of MIP-2 , [MCP-1] , RANTES , inducible NO synthase (iNOS) , and cyclooxygenase-2 (COX-2) in the IEC-18 cell line . Positive_regulation CCL2 IL1B 17077666 1642382 In contrast , Dex treatment inhibited the *induced* production of GM-CSF , IL-6 , IL-8 , MCP-3 , and RANTES , but not [MCP-1] . Positive_regulation CCL2 IL1B 17191021 1688463 Resveratrol ( 1-100 microM ) dose-dependently inhibited *stimulated* [MCP-1] secretion , with approximately 45 % inhibition at 50 microM resveratrol . Positive_regulation CCL2 IL1B 17885219 1823783 Furthermore , silencing of MK2 in endothelial cells by siRNA reduced the *induced* expression of VCAM-1 and [MCP-1] . Positive_regulation CCL2 IL1B 18007025 1860274 In addition , ligand activated PPARdelta attenuated the promoter activity and expression of [monocyte chemoattractant protein-1] *induced* by . Positive_regulation CCL2 IL1B 18565769 1984265 In the *presence* of , FGF-18 increased expression of ADAMTS-4 , aggrecan , BMP-2 , COL2A1 , CCL3 , CCL4 , CCL20 , CXCL1 , CXCL3 , CXCL6 , IL-1beta , IL-6 , and IL-8 and decreased ADAMTS-5 , MMP-13 , [CCL2] , and CCL8 . Positive_regulation CCL2 IL1B 18950946 2041297 Our results showed that ( 10 ng/ml ) *stimulated* a statistically significant increase in [MCP-1] and MMP-2 production and decreased production of TIMP-2 by both normal and keloid derived fibroblasts ( Student 's t-test , p < 0.05 ) , but to differing extents . Positive_regulation CCL2 IL1B 19002429 2022192 induced a time dependent *increase* in [Mcp-1] and Mip-2 ( also known as Cxcl2 ) mRNA expression after 6 h of stimulation in insulinoma (INS)-1 and neonatal rat islet cells . Positive_regulation CCL2 IL1B 19117935 2060755 also *induced* [MCP-1] , IL-6 , and IL-8 more vigorously in TAO derived fibroblasts . Positive_regulation CCL2 IL1B 19124762 2019593 Priming of the cells with ER stress inducers ( tunicamycin , thapsigargin , A23187 , and AB5 subtilase cytotoxin ) caused blunted induction of [MCP-1] in *response* to TNF-alpha , , macrophage derived factors , or bystander macrophages . Positive_regulation CCL2 IL1B 19426980 2157195 [MCP-1] expression was *regulated* by and TNF-alpha and cytokine induced PREB expression . Positive_regulation CCL2 IL1B 19439823 2090483 Furthermore , these data suggested that [MCP-1] was *regulated* by TNF-alpha and , and activated by both cytokines and biomaterials . Positive_regulation CCL2 IL1B 19446037 2136060 The histone deacetylase inhibitor Trihostatin A abolished the inhibitory actions of hypoxia on *induced* [MCP-1] gene expression . Positive_regulation CCL2 IL1B 19446813 2141899 Digitoxin , employing therapeutical concentrations used in patients ( 3-30nM ) , potently inhibited the *induced* expression of [MCP-1] and VCAM-1 in EC and the capacity of corresponding cell culture supernatants on monocyte migration as well as monocyte adhesion to endothelial monolayers , respectively . Positive_regulation CCL2 IL1B 19561397 2149691 *promotes* the expression of [monocyte chemoattractant protein-1] in human aorta smooth muscle cells via multiple signaling pathways . Positive_regulation CCL2 IL1B 19561397 2149692 In this study , we examined the intracellular signaling pathway of *induced* [MCP1] expression using various chemical inhibitors . Positive_regulation CCL2 IL1B 19561397 2149693 The pretreatment of a phosphatidylcholine ( PC ) -specific PLC ( PC-PLC ) inhibitor ( D609 ) , PKC inhibitors , or an NF-kapaB inhibitor completely suppressed the *induced* [MCP1] expression through blocking NF-gammaB translocation to the nucleus . Positive_regulation CCL2 IL1B 19561397 2149694 These results suggest that *induces* [MCP1] expression through activation of NF-kappaB via the PC-PLC/PKC signaling pathway . Positive_regulation CCL2 IL1B 19577550 2117559 This study aims to test the ability of and TNF-alpha to *stimulate* [CCL2] and CCL7 protein production in rat astrocyte cultures , and to elucidate signaling pathways involved in the cytokine stimulated chemokine upregulation . Positive_regulation CCL2 IL1B 20029461 2192296 and IL-18 also significantly enhanced eosinophil survival , and *induced* the release of IL-6 and chemokines CXCL8 and [CCL2] via the activation of the NF-kappaB , p38 MAPK and ERK pathways . Positive_regulation CCL2 IL1B 20032224 2205113 GTE ( 2.5-40 microg/ml ) inhibited *induced* [MCP-1/CCL2] ( 10 ng/ml ) , RANTES/CCL5 , GROalpha/CXCL1 and IL-8/CXCL8 production in human RA synovial fibroblasts ( P < 0.05 ) . Positive_regulation CCL2 IL1B 20050970 2241380 These results indicate that the activation of the MEK/ERK pathway and the consequent expression are *essential* for glutamate stimulated [MCP-1] production in the hippocampus . Positive_regulation CCL2 IL1B 20478455 2263039 and IL-6 simultaneously *induced* IL-8 and [monocyte chemoattractant protein-1] secretion in PDL cells , whereas SOCS-3 overexpression suppressed secretion of these chemokines through inhibition of phosphorylation in downstream signaling . Positive_regulation CCL2 IL1B 21544387 407751 We compared the in vitro effects of various cytokines on the expression of monocyte chemoattractant protein-1 ( MCP-1 ) in glioma cell lines and found that [MCP-1] expression was highly *induced* by tumor necrosis factor-alpha (TNF alpha) and . Positive_regulation CCL2 IL1B 22517618 2618471 Here we demonstrate that significantly *increased* the expression and release of interleukin-8 ( CXCL8 ) , [monocyte chemotactic protein-1] ( CCL2 ) , and granulocyte macrophage colony stimulating factor ( CSF2 ) by primary human myometrial cells . Positive_regulation CCL2 IL1B 22517618 2618474 Using selective EP receptor agonists and a selective EP(4) antagonist , we show that PGE ( 2 ) mediates the repression of *induced* release of CXCL8 , [CCL2] , and CSF2 via activation of the EP(2) and EP(4) receptors . Positive_regulation CCL2 IL1B 22811570 2676699 Overexpression of IL1R2 using cell transfection inhibited IL1 and *mediated* [MCP1] secretion . Positive_regulation CCL2 IL1B 7589574 334064 The effect was most obvious after 16 to 20 h , when induction by PDGF alone had already faded , but still PDGF strongly enhanced *induced* [MCP-1] mRNA expression . Positive_regulation CCL2 IL1B 7806062 292502 Constituitive [MCP-1] mRNA levels in Caco-2 cells were *up-regulated* by and down-regulated by dexamethasone . Positive_regulation CCL2 IL1B 7811465 292536 We determined that stimulation of resident rat PAMs with bacterial lipopolysaccharide (LPS) , murine tumor necrosis factor-alpha , or human *resulted* in the inducible expression of MCP-1 mRNA and the secretion of biologically active [MCP-1] . Positive_regulation CCL2 IL1B 7942160 276331 [MCP-1] expression at both the protein and mRNA levels was greatly *increased* by and TNF-alpha . Positive_regulation CCL2 IL1B 7942160 276333 At the mRNA level , and TNF-alpha strongly *induced* [MCP-1] expression ; Positive_regulation CCL2 IL1B 8120407 251052 The constitutive or *stimulated* release of [MCP-1] , by contrast , was markedly enhanced by IL-4 and IFN-gamma . Positive_regulation CCL2 IL1B 8189067 257013 In connective tissue cells , was the best *inducer* of [MCP-1] , but IFN-gamma was a superior inducer of MCP-2 . Positive_regulation CCL2 IL1B 8587246 341587 Northern blot analysis revealed that MCP-1 mRNA was constitutively expressed by GEN and that and tumor necrosis factor-alpha (TNF-alpha) *increased* [MCP-1] mRNA levels in a dose- and time dependent manner . Positive_regulation CCL2 IL1B 8587246 341589 Inhibition study using protein kinase inhibitors revealed that [MCP-1] mRNA expression *induced* by and TNF-alpha was suppressed by the tyrosine kinase inhibitor genistein , not by the protein kinase C inhibitors staurosporine or H-7 , or the protein kinase A inhibitor H-89 , suggesting an important role of tyrosine kinase in the cytokine induced MCP-1 gene expression . Positive_regulation CCL2 IL1B 8831705 385816 Compared to mock transfectants , the vector cells showed blunted expression of gelatinase B , stromelysin and [monocyte chemoattractant protein-1] in *response* to . Positive_regulation CCL2 IL1B 8895322 392455 Finally , and tumor necrosis factor-alpha ( 1-1000 pM ) *stimulated* dose dependent increases in the secretion of interleukin-6 and [monocyte chemoattractant protein-1] at 34 C and 40C . Positive_regulation CCL2 IL1B 8941762 399322 and tumor necrosis factor-alpha *stimulate* synergistically the expression of [monocyte chemoattractant protein-1] in fibroblastic cells derived from human periodontal ligament . Positive_regulation CCL2 IL1B 8941762 399324 The present study demonstrates that and tumor necrosis factor-alpha (TNF-alpha) induce and synergistically *stimulate* [monocyte chemoattractant protein-1] ( MCP-1 ) expression in fibroblasts from human periodontal ligament . Positive_regulation CCL2 IL1B 8941762 399325 Furthermore , in combination with TNF-alpha synergistically *stimulated* the [MCP-1] gene expression in the cells . Positive_regulation CCL2 IL1B 8941762 399326 The [MCP-1] gene product in conditioned medium of IL-1 beta treated fibroblasts from the human periodontal ligament was shown to have a molecular mass of 11,000 Da by immunoprecipitation with the specific antiserum , and also *stimulated* synergistically MCP-1 protein expression in combination with TNF-alpha . Positive_regulation CCL2 IL1B 8943702 400125 RPE monocyte chemotactic protein-1 mRNA peaked at 2 hr and decreased over 8 hr and 24 hr. Whereas , RPE interleukin-8 mRNA was perceptible at 2 hr , maximal at 8 hr , and reduced by 24 hr . Interleukin-7 potentiated *induced* [monocyte chemotactic protein-1] and interleukin-8 steady-state mRNA expression at all interleukin-7 concentrations . Positive_regulation CCL2 IL1B 9040477 415866 Although DEX ( 10 ( -8 ) to 10 ( -6 ) M ) inhibited *stimulated* [MCP-1] and IL-8 production , it did not inhibit TNF-alpha stimulated chemokine secretion . Positive_regulation CCL2 IL1B 9077472 420391 Upon *stimulation* with and tumor necrosis factor-alpha (TNF-alpha) , both HDMECs and HMEC-1 expressed high levels of IL-8 , GRO , and [monocyte chemoattractant protein-1] ( MCP-1 ) . Positive_regulation CCL2 IL1B 9170401 433197 After 4 hours , and IL-8 concentration of the cell-free supernatant had increased by 268 +/- 36 % and 210 +/- 7 % , respectively , and cellular [MCP-1] content had *increased* by 170 +/- 8 % . Positive_regulation CCL2 IL1B 9174597 433555 We present evidence that the nuclear factor (NF)-kappa B-like binding site and the AP-1 binding site located 90 and 68 base pairs upstream of the transcriptional start site , respectively , are required for maximal *induction* of the human [MCP-1] promoter by . Positive_regulation CCL2 IL1B 9376623 465519 MKN28 cells were found to secrete [MCP-1] in *response* to or TNFalpha in a dose- and time dependent manner . Positive_regulation CCL2 IL1B 9441701 475952 Dose- and time dependent RPE cell [MCP-1] secretion was also *observed* following > TNF-alpha > IFN-gamma stimulation , with an average of 4 % of the total MCP-1 retained within RPE . Positive_regulation CCL2 IL1B 9500525 490794 Synergistic *induction* of [MCP-1] and -2 by and interferons in fibroblasts and epithelial cells . Positive_regulation CCL2 IL1B 9520946 493675 The *stimulated* HRPE [MCP-1] production was also unchanged by GHSA . Positive_regulation CCL2 IL1B 9536945 497504 Caco-2 cells , with features more typical of villus absorptive cells , were relatively poor secretors of alpha chemokines but secreted high levels of [MCP-1] in *response* to . Positive_regulation CCL2 IL1B 9610617 508780 *induced* [MCP-1] , CINC , RANTES and ICAM-1 gene expression in a time dependent manner . Positive_regulation CCL2 IL1B 9610617 508790 Dexamethasone suppressed the *induced* [MCP-1] and CINC mRNA . Positive_regulation CCL2 IL1B 9633934 513176 *induced* [monocyte chemoattractant protein-1] gene expression in endothelial cells is blocked by proteasome inhibitors . Positive_regulation CCL2 IL1B 9633934 513178 We present evidence that a proteasome inhibitor , N-acetyl-leucinyl-leucinyl-norleucinal ( norLeu ) , and the protease inhibitor tosyl-Phe-chloromethylketone ( TPCK ) block *induction* of [MCP-1] protein expression . Positive_regulation CCL2 IL1B 9633934 513179 norLeu and TPCK also blocked *induced* [MCP-1] promoter-driven reporter gene expression as well as nuclear factor (NF)-kappaB mediated reporter gene expression . Positive_regulation CCL2 IL1B 9633934 513209 This study demonstrates that the proteasome pathway is involved in *induced* [MCP-1] gene expression in human endothelial cells . Positive_regulation CCL2 IL1B 9657919 516875 and TNF-alpha synergistically *induced* IL-6 and GM-CSF and additively induced IL-8 and [MCP-1] production , while IL-2 , IL-10 , IFN-alpha , and IFN-gamma had little or no additional effects . Positive_regulation CCL2 IL1B 9831176 551447 and interferon-gamma differentially *regulate* release of [monocyte chemotactic protein-1] and interleukin-8 by human bronchial epithelial cells . Positive_regulation CCL2 IL1B 9831176 551459 *increased* both [MCP-1] and IL-8 release , and increased the expression of ICAM-1 and CD40 , but not HLA class II molecules . Positive_regulation CCL2 IL1B 9831176 551464 Our results indicate that IFN-gamma and differentially *regulate* the [MCP-1] and IL-8 release by human bronchial epithelial cells . Positive_regulation CCL2 IL1B 9950608 589839 MG-132 suppressed MGSA/gro-alpha , RANTES , MCP-1 , IL-1beta , M-CSF , and ICAM-1 mRNA expression and secreted RANTES , [MCP-1] , and M-CSF protein , and cell-surface ICAM-1 that were *induced* by , TNF-alpha , and TII . Positive_regulation CCL2 IL1R2 22811570 2676700 Overexpression of using cell transfection *inhibited* IL1 and hCG/IL1B mediated [MCP1] secretion . Positive_regulation CCL2 ITGB2 19175917 2032586 Based on direct blockage of CD36 or CD18 by antibodies , [MCP-1] production may be *mediated* by while MIP-1beta and MCP-1 production may occur upon binding to CD36 . Positive_regulation CCL2 MAP2K6 11278464 811004 [MCP-1] mediated cell adhesion was *inhibited* by a inhibitor but not by a p38-MAPK inhibitor . Positive_regulation CCL2 MAP2K6 11381075 820610 Combined inhibition of MEK by U0126 , p38 by SB202190 , and Janus kinase (jak) by AG490 revealed that GHSA stimulation of IL-8 production was predominately mediated by MEK and to a lesser extent by p38 pathways , whereas activation of , p38 , and jak was *required* for maximal [MCP-1] induction . Positive_regulation CCL2 MAP2K6 11795297 892283 [MCP-1] mediated cell adhesion was *inhibited* by a inhibitor , but not by a p38-MAPK inhibitor . Positive_regulation CCL2 MAP2K6 22361885 2561477 In addition , we revealed that JNK and are *involved* in flagellin induced [MCP-1] expression in E1 cells . Positive_regulation CCL2 MAP2K6 22674286 2675912 Thrombin mediated [CCL2] production was *attenuated* by the thrombin inhibitor PPACK , the protein kinase Cd ( PKCd ) inhibitor rottlerin , the c-Src inhibitor PP2 , epidermal growth factor receptor (EGFR) inhibitor AG-1478 , inhibitors PD98059 and U0126 , or AP-1 inhibitors curcumin and tanshinone IIA . Positive_regulation CCL2 MUC16 21097527 2383265 In the present study we used differentiated primary cultures of normal human bronchial epithelial ( NHBE ) cells to test whether [MCP-1] through its receptor CCR2 *induces* upregulation . Positive_regulation CCL2 RNF150 20648642 2292769 Using a panel of kinase inhibitors , we demonstrated that NOV action on [CCL2] and CXCL1 production *involved* a and a Rho/qROCK/p38/NF-kappaB pathway , respectively . Positive_regulation CCL2 S100B 16551628 1555607 An inhibitor of Src kinase , PP2 , significantly blocked *induced* activation of Src kinase , mitogen activated protein kinases , transcription factors NF-kappaB and STAT3 , superoxide production , tyrosine phosphorylation of Cav-1 , VSMC migration , and expression of the pro-inflammatory genes [monocyte chemotactic protein-1] and interleukin-6 . Positive_regulation CCL2 S100B 22082983 2540798 *induced* NF-?B activation and the expression of several proinflammatory genes ( [MCP-1] , IL-6 , ICAM-1 ) at mRNA and protein levels in RAGE-A10 , among which MCP-1 expression was the most robust . Positive_regulation CCL2 S100B 22082983 2540799 *induced* [MCP-1] expression was dose-dependently blocked by inhibitors of JNK ( SP600125 ) , p38 ( SB203580 ) , MEK-1 ( U0126 ) as well as NF-?B ( Bay117085 ) . Positive_regulation CCL2 S100B 22082983 2540802 Our study demonstrates that *increased* [MCP-1] expression via NF-?B and mitogen activated protein kinase ( JNK , ERK1/2 , and p38 ) pathways in RAGE overexpressed A10 cell lines . Positive_regulation CCL2 S100B 24995813 2956603 The RAGE ligand *stimulated* [MCP-1] ( monocyte chemoattractant protein-1 ) secretion from peritoneal macrophages , but cAMP elevation suppressed it by converting the RAGE isoform from a membrane bound into a soluble form . Positive_regulation CCL2 SMN2 22669976 2632868 dependent *induction* of [CCL2] and IGF1 mRNAs resulted in increased intracellular levels and secretion of the respective protein products . Positive_regulation CCL2 SPHK1 15191888 1295210 *mediates* TNF-alpha induced [MCP-1] gene expression in endothelial cells : upregulation by oscillatory flow . Positive_regulation CCL2 SPHK1 15191888 1295214 We further investigated the *role* of in TNF-alpha induced expression of inflammatory genes , such as [monocyte chemoattractant protein-1] ( MCP-1 ) and VCAM-1 by using small interfering RNA ( siRNA ) specifically for SphK1 . Positive_regulation CCL2 SPHK1 15191888 1295252 These data suggest that *mediates* TNF-alpha induced [MCP-1] gene expression through a p38 MAPK dependent pathway and may participate in oscillatory flow mediated proinflammatory signaling pathway in the vasculature . Positive_regulation CCL2 STAT4 21646799 2442020 is *required* for IFN-ß induced [MCP-1] mRNA expression in murine mast cells . Positive_regulation CCL2 TGM2 22921425 2678263 Under oscillatory flow , activity *increased* the expression of the chemokine [MCP-1] ( CCL2 ) . Positive_regulation CCL2 TLR7 15588425 1345914 MEFs were highly responsive to TLR-ligand activation and secreted high levels of both IL-6 and [MCP-1] in *response* to ligands . Positive_regulation CCL2 TLR7 17293495 1747367 IL-1 receptor antagonist , a competitive inhibitor of IL-1 receptor I (IL-1RI) , also attenuated *induced* proliferation and both basal and TLR induced [MCP-1] expression , indicating at least a partial role of the IL-1RI in mediating these responses . Positive_regulation CCL2 TLR7 17641061 1771341 IFN-gamma mediated survival enables human neutrophils to produce [MCP-1/CCL2] in *response* to activation by ligands . Positive_regulation CCL2 TLR7 19553532 2104067 The first phase is rapid , induces low-level production of [MCP-1] , and is *dependent* on signaling . Positive_regulation CCL2 TLR7 21223583 2493934 The ability of IFNa2 to regulate *induced* interleukin (IL)-6 and CC [chemokine ligand 2] production was also assessed . Positive_regulation CCL2 TLR7 22251703 2544884 Topical imiquimod treatment led to *dependent* and IFN-a/ß receptor 1-dependent ( IFNAR1 dependent ) upregulation of expression of the chemokine [CCL2] in mast cells . Positive_regulation CCL2 TLR7 22442158 2606713 Toll-like receptor (TLR)4 ( -/- ) , TLR9 ( -/- ) , and MyD88 ( -/- ) mice had reduced hepatic macrophage infiltration with decreased MCP-1 and CCR2 expression because signaling is a potent *inducer* of [MCP-1] . Positive_regulation CCL2 TLR7 23542035 2782595 IFNß autocrine feedback is required to sustain *induced* production of [MCP-1] in macrophages . Positive_regulation CCL2 TNF 10331497 614621 Recombinant *induced* a low level [MCP-1] mRNA accumulation in neutrophils , and addition of anti-TNF-alpha IgG blocked 30-70 % of MCP-1 mRNA expression induced with PHA-sup . Positive_regulation CCL2 TNF 10362723 620140 The results support the hypothesis that *mediates* cristobalite induced [MCP-1] and MIP-2 expression through the generation of ROS . Positive_regulation CCL2 TNF 10372996 622123 It has been shown in this and other laboratories that interleukin-1 beta (IL-1beta) and are potent *inducers* of HRPE IL-8 and [MCP-1] secretion . Positive_regulation CCL2 TNF 10372996 622129 IL-1beta and induced dose dependent *increases* in HRPE IL-8 and [MCP-1] secretion with maximal stimulation observed at 2-5 ng/ml . IL-4 alone ( 100 ng/ml ) resulted in a slight increase of MCP-1 and IL-8 secretion . Positive_regulation CCL2 TNF 10372996 622139 HRPE IL-8 and [MCP-1] gene expression and protein production are *stimulated* by IL-1beta or through pathways differentially modulated by IL-4 and GM-CSF . Positive_regulation CCL2 TNF 10413089 630922 In human vascular endothelial cells , interleukin-1beta and *induced* endogenous [monocyte chemoattractant protein-1] protein secretion , mRNA expression and promoter activity . Positive_regulation CCL2 TNF 10496934 647236 Divergent *roles* of and platelet activating factor in endotoxin induced release of [monocyte chemoattractant protein 1] and macrophage inflammatory protein 1beta in chimpanzees . Positive_regulation CCL2 TNF 10497106 647455 Chronic HIV-1 infection of U937 monocytic cells increased the expression of RANTES , MIP-1alpha , MIP-1beta , and IL-8 chemokine genes , but strongly inhibited PMA/PHA- and *induced* [MCP-1] gene transcription . Positive_regulation CCL2 TNF 10559511 566626 Ang II and *induced* the expression of IP-10 ( 1.5 and 3.4-fold ) and [MCP-1] ( 2.4 and 4-fold ) in VSMC . Positive_regulation CCL2 TNF 10602073 655218 Endothelial cells ( EC ) from human aortas , microvessels , and pulmonary arteries were examined for their expression and activity of [monocyte chemotactic protein-1 (MCP-1)] , tissue factor , and thrombomodulin in *response* to on the hydrophilic plasma polymers gamma-butyrolactone ( GBL ) and N-vinyl-2-pyrrolidone ( NVP ) , along with a fibronectin (FN) control . Positive_regulation CCL2 TNF 10602073 655223 *induced* EC expression and activity of [MCP-1] and tissue factor and suppressed that of thrombomodulin on all substrates . Positive_regulation CCL2 TNF 10602073 655225 *increased* [MCP-1] secretion significantly in aortic and pulmonary artery EC but to a lesser extent in microvascular EC . Positive_regulation CCL2 TNF 10636866 660074 Sp1 binding is critical for promoter assembly and *activation* of the [MCP-1] gene by . Positive_regulation CCL2 TNF 10636866 660076 The [monocyte chemoattractant protein-1] gene ( MCP-1 ) is *induced* by the inflammatory cytokine through the coordinate assembly of an NF-kappaB dependent distal regulatory region and a proximal region that has been suggested to bind Sp1 as well as other factors . Positive_regulation CCL2 TNF 10669634 665787 Convergence of redox-sensitive and mitogen activated protein kinase signaling pathways in mediated [monocyte chemoattractant protein-1] *induction* in vascular smooth muscle cells . Positive_regulation CCL2 TNF 10669634 665788 In this study , we show that induces a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 mitogen activated protein kinase ( p38MAPK ) and *increases* [MCP-1] mRNA expression in cultured VSMCs . Positive_regulation CCL2 TNF 10669634 665815 Thus , parallel ROS dependent and ERK1/2 dependent pathways converge to regulate *induced* [MCP-1] gene expression in VSMCs . Positive_regulation CCL2 TNF 10671210 666692 In contrast , synthesis of [MCP-1] and MIP-1alpha was *dependent* on endogenous , but not IL-1 . Positive_regulation CCL2 TNF 10683319 707330 Besides TPA , also distinctively *enhanced* IL-8 and [MCP-1] production . Positive_regulation CCL2 TNF 10690939 670589 Inhibitory effect of troglitazone on alpha *induced* expression of [monocyte chemoattractant protein-1] in human mesangial cells . Positive_regulation CCL2 TNF 10690939 670592 We found that *increased* the secretion of [MCP-1] by 55-fold versus the control and troglitazone significantly inhibited this TNF-alpha induced increase in MCP-1 secretion ( 49.3 % ) . Positive_regulation CCL2 TNF 10690939 670593 We demonstrated that alpha-tocopherol also inhibited *induced* [MCP-1] production in HMCs , although its effects were not as strong as troglitazone . Positive_regulation CCL2 TNF 10768935 685060 IL-8 , IL-1alpha , IL-1beta , MCP-1 , GM-CSF , and mRNA expression *increased* within 1 h postinfection , reached a maximum after 3 to 4 h , and then declined to preinfection levels within 3 h . IL-8 , [MCP-1] , and GM-CSF were secreted by HeLa cells , whereas IL-1alpha and IL-1beta were not secreted and thus were found exclusively intracellularly . Positive_regulation CCL2 TNF 10802155 691682 Inhibitory effect of troglitazone on *induced* expression of [monocyte chemoattractant protein-1] ( MCP-1 ) in human endothelial cells . Positive_regulation CCL2 TNF 10802155 691683 We found that TNF-alpha increased the secretions of MCP-1 119-fold vs. control , and that troglitazone significantly inhibited this *induced* increase in [MCP-1] secretions ( 19.4 % ) . Positive_regulation CCL2 TNF 10805972 692065 Depletion of TGFbeta , , or both TGFbeta and TNFalpha from the mediator pool secreted by mast cells activated via the FcepsilonRI *reduced* the mast-cell-driven fibroblast [MCP-1] response by 80+/-15 , 56+/-11 , or 82+/-5 % , respectively . Positive_regulation CCL2 TNF 10880246 709107 On the other hand , [JE/MCP-1] mRNA expression was detected only in non-parenchymal cells in *response* to and IL-1beta , but not in response to IFN-gamma . Positive_regulation CCL2 TNF 10881930 709223 The addition of IL-1beta and strongly *enhanced* IL-8 , [MCP-1] , and RANTES secretion ; Positive_regulation CCL2 TNF 10889171 710416 IL-8 and [MCP-1] secretion was rapidly *induced* by both IL-1beta and . Positive_regulation CCL2 TNF 11006087 735189 These results indicate that *dependent* expression of [MCP-1] in HASMC is tightly regulated by NF-kappaB and that intracellular copper level is crucial for the TNF-alpha dependent activation of NF-kappaB in HASMC . Positive_regulation CCL2 TNF 11016686 736503 In contrast , *induced* a more rapid increase in [MCP-1] production by SK than OK , peak production occurring after 24 and 72 h , respectively . Positive_regulation CCL2 TNF 11027549 739133 Although *stimulates* [MCP-1] expression and secretion , the mechanism by which TNF-alpha stimulates expression of the MCP-1 gene is not known . Positive_regulation CCL2 TNF 11027549 739144 These findings show that Akt/PKB participates in the *induction* of [MCP-1] gene transcription in endothelial cells . Positive_regulation CCL2 TNF 11053477 743531 Supernatant nitrite , [monocyte chemoattractant protein-1] , and protein levels also *increased* by 1.8- , 7.1- , and 5-fold , respectively . Positive_regulation CCL2 TNF 11133741 769338 Both NiCl ( 2 ) - and *induced* [MCP-1] synthesis was sensitive to D609 , an inhibitor of phosphatidylcholine dependent phospholipase C ( PC-PLC ) . Positive_regulation CCL2 TNF 11133741 769348 Consistent with that finding , stimulation with NiCl ( 2 ) or TNFalpha activated IkappaB kinase-beta (IKKbeta) , and transient transfection of dominant negative IKKbeta strongly inhibited NiCl ( 2 ) - and *induced* [MCP-1] expression . Positive_regulation CCL2 TNF 11164890 763142 *mediated* regulation of [MCP-1] occurs through a distal regulatory region located 2.5 kb upstream of the transcriptional start site . Positive_regulation CCL2 TNF 11244034 792272 Clinical investigations in which the activity of TNF alpha in RA patients was blocked with intravenously administered infliximab , a chimeric anti-TNF alpha monoclonal antibody ( mAB ) , has provided evidence that *regulates* IL-6 , IL-8 , [MCP-1] , and VEGF production , recruitment of immune and inflammatory cells into joints , angiogenesis , and reduction of blood levels of matrix metalloproteinases-1 and -3 . Positive_regulation CCL2 TNF 11381071 820589 IL-4 and -13 , but not IL-10 , enhanced constitutive and *induced* HRPE IL-8 and [MCP-1] secretion . Positive_regulation CCL2 TNF 11381071 820598 IL-13 potentiated *induced* [MCP-1] , but not IL-8 secretion by cocultures . Positive_regulation CCL2 TNF 11518190 851507 We hypothesised that MCP-1 may directly contribute to an inflammatory response in the cardiomyocytes , and in the present study we examined in adult rat cardiomyocytes : ( i ) the effect of tumour necrosis factor (TNF)alpha on MCP-1 production , ( ii ) the effect of MCP-1 on production of other inflammatory cytokines , and ( iii ) if the anti-inflammatory cytokine interleukin (IL)-10 could suppress any *induced* [MCP- 1] production . Positive_regulation CCL2 TNF 11583958 865921 [MCP-1] could be *induced* by exogenous or by postischemic cardiac lymph containing TNF-alpha . Positive_regulation CCL2 TNF 11591574 869485 In A549 cells , interleukin (IL)-1beta and *induced* endogenous [MCP-1] protein secretion and messenger RNA expression . Positive_regulation CCL2 TNF 11673556 872875 On the other hand , [CCL2] , CCL5 , and CXCL12 were expressed on RA FLS , and their production was *regulated* by , IL-1beta , and TGF-beta1 . Positive_regulation CCL2 TNF 11689202 876127 In culture , hematein also significantly inhibited the secretion of soluble VCAM-1 and of [monocyte chemotactic protein-1 (MCP-1)] respectively *induced* by and mildly oxidized low density lipoprotein in human umbilical vein endothelial cell ( HUVEC ) culture . Positive_regulation CCL2 TNF 11689467 876277 LA also strongly inhibited *induced* mRNA expression of [monocyte chemoattractant protein-1] but did not affect expression of TNF-alpha receptor 1 . Positive_regulation CCL2 TNF 11764202 887903 T-614 suppressed *induced* production of IL-6 , IL-8 , and [monocyte chemoattractant protein 1] , and also reduced the accumulation of IL-6 and IL-8 mRNA in a concentration dependent manner . Positive_regulation CCL2 TNF 11876523 918931 Chemokines are produced in a coordinated and sequential manner , with IL-8 and RANTES *induced* by during early stages , and [MCP-1] , IP-10 , Mig , I-TAC , I-309 and MDC induced by IFN-gamma during later stages . Positive_regulation CCL2 TNF 11916194 925458 IL-1beta and both *induced* a dose- and time dependent increase in IL-8 , [MCP-1] and MMP-1 secretion , and weakly stimulated MMP-2 secretion . Positive_regulation CCL2 TNF 11989790 936369 Our results show that pleural fluid isolated human fibroblasts release IL-8 and [MCP-1] upon *stimulation* with IL-1 beta , , and LPS in both a concentration- and time dependent manner . Positive_regulation CCL2 TNF 11989790 936377 induced a 95-fold *increase* in IL-8 and an 84-fold increase in [MCP-1] levels , as compared to the controls . Positive_regulation CCL2 TNF 12399621 1009125 Analogue of cGMP ( 8-bromo-cGMP ) had no significant effect on *induced* [MCP-1] mRNA expression and guanylate cyclase inhibitor ( ODQ ) also had no significant influence on the inhibitory effect of SIN-1 . Positive_regulation CCL2 TNF 12399623 1009126 The additional proinflammatory stimulus *increased* [MCP-1] protein production in 30 as compared to 5 mM D-glucose primed HMC ( 2,194 +/- 568 vs. 1,422 +/- 379 pg MCP-1/10 ( 4 ) cells x ml in 30 vs. 5 mM D-glucose primed HMC +24 h TNFalpha 500 U/ml , p = 0.002 ) . Positive_regulation CCL2 TNF 12540965 1050679 After *stimulation* of [MCP-1-mRNA-transcription] with ( 0.1-1 ng/ml ) , HUVEC 's were washed and an inhibitor of gene transcription , Actinomycin D ( 1 micro g/ml ) , was added in the presence or absence of APC . Positive_regulation CCL2 TNF 12682245 1077653 The *induction* of the [monocyte chemoattractant protein 1] gene ( MCP-1 ) by occurs through an NF-kappaB dependent distal regulatory region and an Sp1 dependent proximal regulatory region that are separated by 2.2 kb of sequence . Positive_regulation CCL2 TNF 12682245 1077654 To investigate how these regions coordinate activation of [MCP-1] in *response* to , experiments were performed to examine the role of coactivators , changes in local chromatin structure , and the acetylation of histones at the MCP-1 regulatory regions . Positive_regulation CCL2 TNF 12720581 1084116 Both isoflavones also dose-dependently decreased [monocyte chemoattractant protein-1] secretion *induced* by in human umbilical vein endothelial cells . Positive_regulation CCL2 TNF 12817708 1030721 Shear stress attenuates *induced* [monocyte chemotactic protein-1] expressions in endothelial cells . Positive_regulation CCL2 TNF 12817708 1030722 The *induced* [monocyte chemotactic protein-1 (MCP-1)] mRNA expressions were significantly attenuated in ECs subjected to a high level of shear stress ( 20 dynes/cm2 ) for 4 or 24 h prior to the addition of TNF-alpha in the presence of flow . Positive_regulation CCL2 TNF 12817708 1030723 Less inhibition of *induced* [MCP-1] mRNA expression was found in ECs pre exposed to a low level of shear stress ( 1.2 dynes/cm2 ) for 24 h as compared with the cells presheared ( pre exposed to shear stress ) for 4 h. Simultaneous exposure of ECs to TNF-alpha and a high or low level of shear stress down-regulated TNF-alpha induced MCP-1 gene expressions , suggesting that the post-flow condition modulates endothelial responses to cytokine stimulation . Positive_regulation CCL2 TNF 12838504 1108037 is *required* for RANTES induced astrocyte [monocyte chemoattractant protein-1] production . Positive_regulation CCL2 TNF 12845752 779846 Interleukin-1 beta , and lipopolysaccharide *induce* expression of [monocyte chemoattractant protein-1] in calf aortic smooth muscle cells . Positive_regulation CCL2 TNF 12960255 1158251 ANP inhibits *induced* endothelial [MCP-1] expression -- involvement of p38 MAPK and MKP-1 . Positive_regulation CCL2 TNF 12960255 1158252 The aim of this study was to determine whether ANP is able to inhibit *induced* expression of [monocyte chemoattractant protein-1] ( MCP-1 ) in endothelial cells and to elucidate the mechanisms involved . Positive_regulation CCL2 TNF 12960255 1158253 Pretreatment of human umbilical vein endothelial cells ( HUVEC ) with ANP significantly reduced *induced* expression of [MCP-1] protein and mRNA . Positive_regulation CCL2 TNF 12960255 1158255 Antisense experiments showed a requirement of MAPK phosphatase-1 (MKP-1) induction and therefore , inhibition of p38 MAPK in the ANP mediated inhibition of *induced* expression of [MCP-1] . Positive_regulation CCL2 TNF 14576080 1199886 Superoxide , H2O2 , and iron are required for *induced* [MCP-1] gene expression in endothelial cells : role of Rac1 and NADPH oxidase . Positive_regulation CCL2 TNF 14576080 1199891 Adenovirus mediated expression of superoxide dismutase and catalase inhibited *induced* [MCP-1] gene expression , suggesting important roles of superoxide ( O ( 2 ) ( - ) . ) and H ( 2 ) O ( 2 ) in MCP-1 gene activation . Positive_regulation CCL2 TNF 14576080 1199892 In addition , the iron chelator 1,2-dimethyl-3-hydroxypyridin-4-one and the hydroxyl radical scavengers dimethylthiourea and dimethyl sulfoxide inhibited *induced* [MCP-1] expression , suggesting important roles of iron and hydroxyl radicals in inflammatory signal activation . Positive_regulation CCL2 TNF 14576080 1199893 In contrast , scavenging of peroxynitrite with 5,10,15,20-tetrakis- ( 4-sulfonatophenyl ) prophyrinato iron ( III ) chloride had no effect on *induced* [MCP-1] expression . Positive_regulation CCL2 TNF 14576080 1199894 generation , with diphenylene iodonium suppressed *induced* [MCP-1] mRNA accumulation . Positive_regulation CCL2 TNF 14576080 1199897 Expression of dominant negative N17Rac1 by adenovirus suppressed *induced* [MCP-1] mRNA levels and MCP-1 protein secretion . Positive_regulation CCL2 TNF 14576080 1199901 Expression of N17Rac1 inhibited *induced* [MCP-1] and NF-kappaB transcriptional activity . Positive_regulation CCL2 TNF 14596794 1160338 LPC did not augment *induction* of [MCP-1] or IL-8 . Positive_regulation CCL2 TNF 14641910 1183807 Based on these data and on evidence from literature we suggest a model for the potential neurodegenerative effect of NF-kappaB in astroglia : Activation of NF-kappaB via *results* in a strongly increased production of [MCP-1] . Positive_regulation CCL2 TNF 14657510 1218751 The effects of VIP on basal or *stimulated* production of [CCL2] ( MCP-1 , monocyte chemotactic protein 1 ) , CXCL8 [ interleukin (IL)-8 ] , IL-6 and TNF-alpha were studied by specific ELISAs ( enzyme linked immunosorbent assays ) . Positive_regulation CCL2 TNF 14682399 1179324 Using semi-quantitative RT-PCR and cell based ELISA , we demonstrated that *induced* the expression of intercellular adhesion molecules-1 and E-selectin , as well as [monocyte chemoattractant protein-1] , in a time- and dose dependent manner in primary human coronary artery endothelial cell cultures . Positive_regulation CCL2 TNF 14736953 1199589 Dexamethasone regulates AP-1 to repress *induced* [MCP-1] production in human glomerular endothelial cells . Positive_regulation CCL2 TNF 14736953 1199599 ( 10 ng/ml ) *increased* [MCP-1] mRNA expression in HGEC and also the release of MCP-1 protein into culture media . Positive_regulation CCL2 TNF 14736953 1199603 These data demonstrate that while TNF-alpha induced MCP-1 production is mediated by the cooperative action of NF-kappa B and AP-1 in HGEC , dexamethasone represses *induced* [MCP-1] production via suppression of AP-1 binding activity . Positive_regulation CCL2 TNF 14961984 1208655 *augmented* IgG1 induced secretion of [MCP-1] and KC . Positive_regulation CCL2 TNF 14978197 1250871 Dual regulation of *induced* [CCL2/monocyte] chemoattractant protein-1 expression in vascular smooth muscle cells by nuclear factor-kappaB and activator protein-1 : modulation by type III phosphodiesterase inhibition . Positive_regulation CCL2 TNF 14978197 1250873 Our results showed that *induced* a marked increase in [CCL2/MCP-1] production in dose- and time dependent manners . Positive_regulation CCL2 TNF 14978197 1250875 2- ( 2-Amino-3-methoxyphenyl ) -4H-1-benzopyran-4-one ( PD98059 ) , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) [ both inhibitors of p42/44 mitogen activated protein kinase (MAPK) kinase ] , and anthra [ 1hyphen ] 9-cd ] pyrazol-6 ( 2H ) -one ( SP600125 ) [ an inhibitor of c-Jun NH ( 2 ) -terminal kinases ( JNKs ) ] attenuated *induced* [CCL2/MCP-1] production , without affecting I-kappaBalpha degradation or p65/nuclear factor-kappaB (NF-kappaB) nuclear translocation . Positive_regulation CCL2 TNF 14978197 1250877 The NF-kappaB inhibitor carbobenzoxy-l-leucyl-l-leucyl-l-leucinal ( MG132 ) attenuated *induced* [CCL2/MCP-1] production in the presence of increased phospho-JNK and phospho-c-Jun levels . Positive_regulation CCL2 TNF 14978197 1250878 When SP600125 was added simultaneously , MG132 completely inhibited *induced* [CCL2/MCP-1] production . Positive_regulation CCL2 TNF 14978197 1250879 Finally , the pretreatment of VSMCs with PTX or cilostamide , but not denbufylline , reduced *induced* [CCL2/MCP-1] production , which was preceded by attenuation of p65/NF-kappaB nuclear translocation , p42/44 MAPK , and JNK-c-Jun phosphorylation , and c-Fos up-regulation . Positive_regulation CCL2 TNF 14978197 1250881 These data indicate that *stimulated* [CCL2/MCP-1] production in rat VSMCs is dually regulated by activator protein-1 (AP-1) and NF-kappaB pathways , and inhibition of type III phosphodiesterase contributes substantially to the suppressive effect of PTX on CCL2/MCP-1 production via down-regulation of AP-1 and NF-kappaB signals . Positive_regulation CCL2 TNF 15018305 1183070 Nifedipine inhibits *induced* [monocyte chemoattractant protein-1] overexpression by blocking NADPH oxidase mediated reactive oxygen species generation . Positive_regulation CCL2 TNF 15018305 1183071 In this study , we investigated whether nifedipine , one of the most popular DHPs , could inhibit *induced* reactive oxygen species ( ROS ) generation and subsequent [monocyte chemoattractant protein-1] ( MCP-1 ) expression in human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation CCL2 TNF 15018305 1183076 The results demonstrate that nifedipine could inhibit *induced* [MCP-1] overexpression in HUVEC by suppressing NADPH oxidase mediated ROS generation . Positive_regulation CCL2 TNF 15136050 1245985 Aspirin at the dose as low as 10 microg/ml significantly inhibited the release of *stimulated* [MCP-1] by 29.1 % ( P = 0.008 ) and IL-8 by 26.9 % ( P = 0.0146 ) as compared to TNF stimulated release . Positive_regulation CCL2 TNF 15161854 1252953 The IC ( 50 ) for inhibition of [MCP-1] secretion *induced* by IL-1beta , , and hRPE-monocyte binding was 16 , 12 , and less than 3 micro M , respectively . Positive_regulation CCL2 TNF 15191888 1295211 Sphingosine kinase-1 mediates *induced* [MCP-1] gene expression in endothelial cells : upregulation by oscillatory flow . Positive_regulation CCL2 TNF 15191888 1295215 We further investigated the role of SphK1 in *induced* expression of inflammatory genes , such as [monocyte chemoattractant protein-1] ( MCP-1 ) and VCAM-1 by using small interfering RNA ( siRNA ) specifically for SphK1 . Positive_regulation CCL2 TNF 15191888 1295220 Treatment of endothelial cells with SphK1 siRNA suppressed *induced* increase in [MCP-1] mRNA levels , MCP-1 protein secretion , and activation of p38 MAPK . Positive_regulation CCL2 TNF 15191888 1295253 These data suggest that SphK1 mediates *induced* [MCP-1] gene expression through a p38 MAPK dependent pathway and may participate in oscillatory flow mediated proinflammatory signaling pathway in the vasculature . Positive_regulation CCL2 TNF 15194461 1259936 *induced* production of interleukin-1beta and [monocyte chemoattractant protein-1] from cultured cardiomyocytes was reduced significantly by IMD-0354 . Positive_regulation CCL2 TNF 15205118 1289015 *increased* the number of macrophages and [MCP-1] mRNA expression in scarred mucosa from 4 h , whereas it increased MPO activities ( marker of neutrophil infiltration ) and mRNA expression of MIP-2 and CINC-2alpha from 24 h. Anti-MCP-1 antibody inhibited leukocyte infiltration with reduction of the levels of C-X-C chemokines and prevented ulcer recurrence . Positive_regulation CCL2 TNF 15274652 1276717 Our data indicated that M-CSF and [MCP-1] were *regulated* by IL-1alpha and . Positive_regulation CCL2 TNF 15293554 1278958 The mRNA accumulation of IL-8 , [MCP-1] , RANTES , and eotaxin , and activation of NF-kappaB were *induced* by for 2 h ; Positive_regulation CCL2 TNF 15531761 1360347 We reported here that the PPARgamma agonists 15-deoxy-Delta ( 12,14 ) -PGJ ( 2 ) ( 15d-PGJ ( 2 ) ) and troglitazone , but not PPARalpha agonist WY-14643 , inhibited *induced* production of eotaxin and [monocyte chemotactic protein-1 (MCP-1)] but not IL-8 . Positive_regulation CCL2 TNF 15553662 1338684 We have previously shown that nifedipine , one of the most popular dihydropyridine based calcium antagonists ( DHPs ) , blocked *induced* reactive oxygen species generation and subsequent [monocyte chemoattractant protein-1] expression in endothelial cells ( ECs ) , thus suggesting that nifedipine may inhibit monocyte recruitment , an initiating step in atherosclerosis . Positive_regulation CCL2 TNF 15553663 1338687 We have previously shown that nifedipine , one of the most popular dihydropyridine based calcium antagonists , blocked *induced* [monocyte chemoattractant protein-1] expression in endothelial cells ( ECs ) through its antioxidative properties . Positive_regulation CCL2 TNF 15562246 1380587 In contrast , *induced* substantial increases in IL-6 , TNF-alpha , metallothionein , [MCP-1] , and NGF mRNAs , the largest increase being with MCP-1 ( 14.5-fold ) . Positive_regulation CCL2 TNF 15562246 1380589 [MCP-1] and NGF secretion *increased* 8- to 10-fold with , whereas leptin and adiponectin did not change . Positive_regulation CCL2 TNF 15631627 1362352 Stimulation of HeLa and A549 cells with CpG-ODN induced secretion of [monocyte chemoattractant protein-1] and reduction of spontaneous and *induced* apoptosis . Positive_regulation CCL2 TNF 15671098 1388303 [MCP-1] is *stimulated* by IL-1beta , , IL-8 , IL-4 , and IL-6 + IL-6-soluble receptor and is decreased by dexamethasone , IL-10 , metformin , and thiazolidinediones . Positive_regulation CCL2 TNF 15881228 1406424 Although *stimulated* the AP-1 mediated expression of the monocyte chemoattractant [JE/MCP-1] , this stimulation was inhibited by DHS . Positive_regulation CCL2 TNF 15921025 1413657 Nifedipine inhibits *induced* upregulation of [monocyte chemoattractant protein-1] mRNA levels by suppressing CD40 expression in endothelial cells . Positive_regulation CCL2 TNF 15921025 1413659 We have previously shown that nifedipine , one of the most popular DHPs , inhibits *induced* reactive oxygen species generation and subsequent [monocyte chemoattractant protein-1] ( MCP-1 ) expression in human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation CCL2 TNF 15921025 1413662 These results demonstrate that nifedipine could inhibit the *induced* upregulation of [MCP-1] mRNA levels via suppression of CD40 expression in HUVEC . Positive_regulation CCL2 TNF 16001981 1441303 [CCL2] is *activated* by and is essential for recruitment of monocytes and T cells to the site of mycobacterial infection . Positive_regulation CCL2 TNF 16023081 1441581 Ellagic acid inhibited platelet derived growth factor (PDGF)-BB induced proliferation and migration , interleukin (IL)-1beta- and *induced* [monocyte chemoattractant protein-1] production , and expression of alpha-smooth muscle actin and collagen genes . Positive_regulation CCL2 TNF 16081883 1466275 However , TNF-R2 was dispensable for induction of alveolar [MCP-1] expression in *response* to transmembrane expressed by antigen-specific CD8+ T cells , and the effects of the two receptors seem to be additive . Positive_regulation CCL2 TNF 16105652 1448341 Hypoxia reduces constitutive and *induced* expression of [monocyte chemoattractant protein-1] in human proximal renal tubular cells . Positive_regulation CCL2 TNF 16105652 1448342 Here , we investigated the regulatory effects of hypoxia on constitutive and *stimulated* expression of [monocyte chemoattractant protein-1] ( MCP-1 ) in cultured human proximal renal tubular cells ( HPTECs ) . Positive_regulation CCL2 TNF 16155367 1467439 The two new PPAR-gamma agonists and 15d-PGJ2 also inhibited *induced* interleukin-6 (IL-6) and [monocyte chemoattractant protein-1] ( MCP-1 ) production in supernatants of TNF-alpha stimulated ECs , whereas ciglitazone and DIM-C-pPhCH ( 3 ) did not decrease TNF-alpha induced expression of these two proteins . Positive_regulation CCL2 TNF 16190362 1462608 Hypoxia reduced basal and *stimulated* [MCP-1] expression , while it induced VEGF expression in HPTECs . Positive_regulation CCL2 TNF 16253226 1483789 *induced* [monocyte chemoattractant protein-1] ( MCP-1 ) expression was also attenuated by addition of PGG . Positive_regulation CCL2 TNF 16269157 1525813 *induced* [MCP-1] expression was also attenuated by the addition of AR . Positive_regulation CCL2 TNF 16273763 1479722 Furthermore , up-regulation of secreted [MCP-1] and VEGF was *observed* following stimulation with . Positive_regulation CCL2 TNF 16294327 1532380 Curcumin inhibited platelet derived growth factor ( PDGF ) -induced proliferation , alpha-smooth muscle actin gene expression , interleukin-1beta- and *induced* [MCP-1] production , type I collagen production , and expression of type I and type III collagen genes . Positive_regulation CCL2 TNF 16358608 1492983 The roles of cyclooxygenase (COX) 2 and prostaglandins in the mediation of *stimulated* [CCL2] gene expression were also investigated . Positive_regulation CCL2 TNF 16358608 1492984 The Northern blot analysis showed that *stimulated* the expression of [CCL2] and COX-2 genes , and the synthesis of CCL2 messenger RNA was COX-2 dependent . Positive_regulation CCL2 TNF 16358608 1492988 Curcumin ( AP-1 inhibitor ) markedly suppressed the *induced* [CCL2] expression . Positive_regulation CCL2 TNF 16391493 1560930 These findings indicate that berberine dose-dependently inhibited the expression of IL-8 and [MCP-1] *induced* by IL-1beta or . Positive_regulation CCL2 TNF 16413026 1618807 In addition to fractalkine , ALA successfully inhibited *stimulated* expression of vascular cell adhesion molecule-1 and [monocyte chemotactic protein-1] in cultured VSMCs . Positive_regulation CCL2 TNF 16601113 1568691 Interestingly , inhibition of GSK-3beta by antisense oligonucleotides or pharmacological agent ( 10 mm lithium ) potentiated *induced* expression of IL-6 and [MCP-1] by 2-6-fold suggesting that inhibition of GSK-3beta under inflammatory conditions ( exposure to TNF-alpha and IL-1beta ) may contribute to enhanced cytokine expression . Positive_regulation CCL2 TNF 16750176 1570659 In MC3T3-E1 cells , apigenin dose-dependently ( from 5 to 20 microM ) inhibits *induced* production of the osteoclastogenic cytokines , IL-6 ( interleukin-6 ) , RANTES ( regulated upon activation , normal T cell expressed and -secreted ) , [monocyte chemoattractant protein-1] ( MCP-1 ) and MCP-3 . Positive_regulation CCL2 TNF 16776679 1573093 IL-6 , IL-8 , [MCP-1] , RANTES and eotaxin were detected from fibroblasts cultures , and were all *up-regulated* by . Positive_regulation CCL2 TNF 16784723 1585632 Suppressive effects of antimycotics on *induced* CCL27 , [CCL2] , and CCL5 production in human keratinocytes . Positive_regulation CCL2 TNF 16784723 1585635 We examined in vitro effects of antimycotics on *induced* CCL27 , [CCL2] , and CCL5 production in human keratinocytes . Positive_regulation CCL2 TNF 16784723 1585638 Antimycotics ketoconazole and terbinafine hydrochloride suppressed *induced* CCL27 , [CCL2] , and CCL5 secretion and mRNA expression in keratinocytes in parallel to the inhibition of NF-kappaB activity while fluconazole was ineffective . Positive_regulation CCL2 TNF 16784723 1585641 Anti-prostaglandin E2 ( PGE2 ) antiserum or antisense oligonucleotides against PGE2 receptor EP2 or EP3 abrogated inhibitory effects of ketoconazole and terbinafine hydrochloride on *induced* NF-kappaB activity and CCL27 , [CCL2] , and CCL5 production , indicating the involvement of endogenous PGE2 in the inhibitory effects . Positive_regulation CCL2 TNF 16784723 1585646 Carboxyheptyl imidazole also suppressed *induced* NF-kappaB activity and CCL27 , [CCL2] , and CCL5 production . Positive_regulation CCL2 TNF 16784723 1585651 These results suggest that ketoconazole and terbinafine hydrochloride may suppress *induced* NF-kappaB activity and CCL27 , [CCL2] , and CCL5 production by increasing PGE2 release from keratinocytes . Positive_regulation CCL2 TNF 16847329 1588182 The [monocyte chemoattractant protein 1] gene ( MCP-1 ) is *regulated* by through an NF-kappaB dependent distal enhancer and an Sp1 dependent promoter-proximal regulatory region . Positive_regulation CCL2 TNF 16904979 1601525 *induced* release of [monocyte chemoattractant protein 1] ( MCP-1 ) was determined by enzyme linked immunosorbent assay . Positive_regulation CCL2 TNF 16904979 1601527 CHCsil decreased *induced* [MCP-1] by 46 % ( P < .05 ) , compared with control . Positive_regulation CCL2 TNF 16960104 1633403 *stimulated* [MCP-1] expression in all cell types tested , whereas FGF-2 mediated upregulation of MCP-1 was found only in NEMCs but not in others , a finding that was not affected by VEGF in vitro and in vivo . Positive_regulation CCL2 TNF 17184171 1724543 Effects of PGC-1alpha on *induced* [MCP-1] and VCAM-1 expression and NF-kappaB activation in human aortic smooth muscle and endothelial cells . Positive_regulation CCL2 TNF 17184171 1724566 Consequently , NF-kappaB activity and [MCP-1] and VCAM-1 *induced* by are suppressed . Positive_regulation CCL2 TNF 17255125 1710371 PPAR-gamma 's activation with 15d-PGJ2 or pioglitazone reduced basal and *stimulated* [MCP-1] expression at mRNA and protein levels at 24 h under normoxia . Positive_regulation CCL2 TNF 17295000 1664655 Azelnidipine , 10 nmol/l , was found to inhibit the *induced* upregulation of [monocyte chemoattractant protein-1] mRNA levels in human umbilical vein endothelial cells significantly . Positive_regulation CCL2 TNF 17295000 1664656 Furthermore , azelnidipine suppressed *induced* [monocyte chemoattractant protein-1] production by human umbilical vein endothelial cells . Positive_regulation CCL2 TNF 17307163 1705288 Synergistic effect of PGD2 via prostanoid DP receptor on *induced* production of [MCP-1] and IL-8 in human monocytic THP-1 cells . Positive_regulation CCL2 TNF 17307163 1705294 In addition , the selective prostanoid DP receptor antagonist , pinagladin ( ( Z ) -7- [ ( 1R,2R,3S,5S ) -2- ( benzothiophen-3-ylcarbonylamide ) -10-norpinan-3-yl ] hept-5-enoic acid ) inhibited the production of [MCP-1] and IL-8 upon combined *stimulation* with PGD2 and . Positive_regulation CCL2 TNF 17307163 1705310 Our findings suggest that activation of the prostanoid DP receptor on THP-1 cells enhances *induced* [MCP-1] and IL-8 production via the cAMP/PKA signaling pathway . Positive_regulation CCL2 TNF 17322026 1726305 Similarly , IL-1beta- and *induced* expression of IL-6 , IL-8 , granulocyte macrophage-colony stimulating factor ( GM-CSF ) , regulated and activation normal T cell expressed and secreted ( RANTES ) , growth related oncogene alpha , and [monocyte chemotactic protein-1 (MCP-1)] was also significantly repressed . Positive_regulation CCL2 TNF 17376491 1766002 In addition to its effect on basal gene expression , we showed that B [ a ] P significantly enhanced *induced* expression of [MCP-1] . Positive_regulation CCL2 TNF 17424890 1723873 Northern blot showed that *stimulated* [CCL2] gene expression in NPFs . Positive_regulation CCL2 TNF 17424890 1723879 PD98059 and curcunmin ( AP-1 inhibitor ) markedly suppressed the *induced* [CCL2] expression , whereas the effect of SB203580 was less noted . Positive_regulation CCL2 TNF 17424890 1723880 *induces* [CCL2] transcription in NPFs . Positive_regulation CCL2 TNF 17604001 1768464 We found that , in glomerular podocytes , *induction* of [monocyte chemoattractant protein 1] ( MCP-1 ) and inducible nitric oxide synthase (iNOS) by was abrogated by K-7174 . Positive_regulation CCL2 TNF 17604001 1768466 Furthermore , K-7174 elicited UPR abrogated *induction* of [MCP-1] and iNOS not only by but also by medium conditioned by activated macrophages . Positive_regulation CCL2 TNF 17712227 1829814 ID8 cells constitutively expressed CXCL16 and [CCL2] , but only CCL2 expression was *enhanced* by LPS , IL-1 and . Positive_regulation CCL2 TNF 17827743 1791590 *induced* [monocyte chemoattractant protein 1] ( MCP-1 ) expression was also attenuated by treatment of cornuside . Positive_regulation CCL2 TNF 17916652 1830234 Prostaglandin E2 modulates *induced* [MCP-1] synthesis in pancreatic acinar cells in a PKA dependent manner . Positive_regulation CCL2 TNF 17916652 1830241 In the *presence* of , [MCP-1] was upregulated . Positive_regulation CCL2 TNF 17916652 1830242 Coincubation with PGE ( 2 ) enhanced the *induced* [MCP-1] synthesis significantly . Positive_regulation CCL2 TNF 17916652 1830243 PGE ( 2 ) modulates the *induced* [MCP-1] synthesis and secretion from acinar cells . Positive_regulation CCL2 TNF 18084847 1834622 We have previously shown that nifedipine , one of the most popular DHPs , blocks *induced* [monocyte chemoattractant protein-1] as well as vascular cell adhesion molecule-1 ( VCAM-1 ) expression in endothelial cells by suppressing reactive oxygen species generation ( ROS ) . Positive_regulation CCL2 TNF 18291098 1885508 Anti-inflammatory effect of resveratrol on *induced* [MCP-1] expression in adipocytes . Positive_regulation CCL2 TNF 18291098 1885509 In this study we investigated the effects of resveratrol upon both *induced* [MCP-1] gene expression and its underlying signaling pathways in 3T3-L1 adipocytes . Positive_regulation CCL2 TNF 18291098 1885510 Resveratrol was found to inhibit *induced* [MCP-1] secretion and gene transcription , as well as promoter activity , which based on down-regulation of TNF-alpha induced MCP-1 transcription . Positive_regulation CCL2 TNF 18291098 1885511 Nuclear factor (NF)-kappaB was determined to play a major role in the *induced* [MCP-1] expression . Positive_regulation CCL2 TNF 18397796 1893672 Epigallocatechin-3-O-gallate inhibits *induced* [monocyte chemotactic protein-1] production from vascular endothelial cells . Positive_regulation CCL2 TNF 18397796 1893673 In this study , we investigated the mechanisms by which EGCG may inhibit *induced* [MCP-1] production in bovine coronary artery endothelial cells . Positive_regulation CCL2 TNF 18397796 1893674 *increased* [MCP-1] production in both a concentration and time dependent manner . Positive_regulation CCL2 TNF 18397796 1893675 Inhibitors of phosphatidylinositol-3-OH kinase ( PI-3 kinase ) , LY294002 and wortmannin , decreased *induced* [MCP-1] production . Positive_regulation CCL2 TNF 18397796 1893678 In conclusion , EGCG inhibited *induced* [MCP-1] production . Positive_regulation CCL2 TNF 18441197 1921016 Angiotensin II and synergistically *promote* [monocyte chemoattractant protein-1] expression : roles of NF-kappaB , p38 , and reactive oxygen species . Positive_regulation CCL2 TNF 18441197 1921017 ANG II and *stimulated* [MCP-1] expression in a synergistic manner in vascular smooth muscle cells . Positive_regulation CCL2 TNF 18441197 1921019 In contrast , *induced* [MCP-1] expression was potently suppressed by blockade of NF-kappaB activation but only modestly suppressed by blockade of p38 activation . Positive_regulation CCL2 TNF 18441197 1921023 Furthermore , ANG II- and *stimulated* [MCP-1] expression was partially suppressed by ROS inhibitors . Positive_regulation CCL2 TNF 18441197 1921024 These results suggested that ANG II and synergistically *stimulate* [MCP-1] expression via the utilization of distinct intracellular signaling pathways ( p38- and NFkappaB dependent pathways ) and that these pathways are activated in ROS dependent and -independent manners . Positive_regulation CCL2 TNF 18489909 2019767 Quercetin was able to reduce *induced* upregulation of VCAM-1 , ICAM-1 and [MCP-1] at both the protein and transcript ( mRNA ) level in HUASMC . Positive_regulation CCL2 TNF 18644347 1947743 As a result , *induced* expression of inflammatory cytokines , CXCL1/KC and [CCL2/MCP-1] , was clearly inhibited by Celecoxib . Positive_regulation CCL2 TNF 18656701 1942673 Selective inhibitors of p38 MAPK ( SB203580 ) , JNK ( SP600125 ) and ERK ( PD98059 ) could suppress *induced* [CCL2] and ICAM-1 expression , while only p38 MAPK and ERK inhibitors could suppress TNF-alpha induced VCAM-1 expression . Positive_regulation CCL2 TNF 18784644 1980581 In vitro , 1,25 ( OH ) 2D attenuated *induced* [MCP-1] expression by human proximal tubule cells . Positive_regulation CCL2 TNF 18791174 1993226 Effects of tunicamycin and thapsigargin on IL-1beta- and *stimulated* [MCP-1] mRNA expression and protein production were further examined by RT-PCR and ELISA , respectively . Positive_regulation CCL2 TNF 18791174 1993228 They also caused corresponding reductions in IL-1beta- and *induced* [MCP-1] mRNA expression and protein production . Positive_regulation CCL2 TNF 18799549 1981142 We found that , in murine podocytes , expression of [monocyte chemoattractant protein 1] ( MCP-1 ) in *response* to was suppressed by indomethacin but not by ibuprofen . Positive_regulation CCL2 TNF 19020780 1992180 The results demonstrated that glucosamine but not N-acetylglucosamine suppressed *induced* expression of [MCP-1] and ICAM-1 at both the mRNA and protein levels . Positive_regulation CCL2 TNF 19020780 1992182 Thus , glucosamine is likely to suppress endothelial cell activation ( *induced* ICAM-1 and [MCP-1] expression ) possibly by affecting p38MAPK and NF-kappaB signaling via O-GlcNAc modification . Positive_regulation CCL2 TNF 19026986 2017155 Furthermore , knockdown of Foxo1 as well as C/EBPbeta inhibits *induced* expression of [MCP-1] and IL-6 in 3T3-L1 adipocytes . Positive_regulation CCL2 TNF 19107603 2047669 c-Jun N-terminal kinases inhibitor suppresses the *induced* [MCP-1] expression in human umbilical vein endothelial cells . Positive_regulation CCL2 TNF 19107603 2047670 A recent report indicated that [MCP-1] expression in human umbilical vein endothelial cells ( HUVECs ) is *induced* by the stimulation of via the c-Jun N-terminal kinases (JNK) pathway . Positive_regulation CCL2 TNF 19107603 2047673 In conclusion , JNKI-1 partially inhibits the *induced* [MCP-1] expression in HUVECs , and therefore JNKI-1 may be of therapeutic value in the treatment of diseases such as atherosclerosis . Positive_regulation CCL2 TNF 19122171 2037059 IGF1R downregulation uncovered an insulin induced reduction in activation of NF-kappaB and inhibition of [MCP-1] upregulation in *response* to . Positive_regulation CCL2 TNF 19124762 2019592 Priming of the cells with ER stress inducers ( tunicamycin , thapsigargin , A23187 , and AB5 subtilase cytotoxin ) caused blunted induction of [MCP-1] in *response* to , IL-1beta , macrophage derived factors , or bystander macrophages . Positive_regulation CCL2 TNF 19201463 2049769 *mediated* stimulation of [CCL2] secretion was completely inhibited by incubating the trophoblast cells with the p38-MAPK inhibitor SB203580 , whereas CCL5 secretion was inhibited by treating the trophoblast cells with inhibitors specific for JNK ( SP600125 ) and ERK kinase ( U0126 ) . Positive_regulation CCL2 TNF 19225413 2039888 strongly *increased* the production of [CCL2] , CCL5 , and CXCL8 ; Positive_regulation CCL2 TNF 19228962 2039957 Moreover , peripheral signaling was *required* to stimulate microglia to produce [MCP-1/CCL2] . Positive_regulation CCL2 TNF 19234337 2079499 Studies using human ECs demonstrated that *induced* [CCL2] production was also inhibited by the NAD(P)H oxidase inhibitor DPI , the antioxidant N-acetyl-L-cysteine , or the superoxide scavenger Tiron , further indicating that inhibition occurs through the NAD ( P ) H/ROS pathway . Positive_regulation CCL2 TNF 19277846 2106022 Sulforaphane inhibits *induced* activation of p38 MAP kinase and VCAM-1 and [MCP-1] expression in endothelial cells . Positive_regulation CCL2 TNF 19277846 2106024 One-hour pretreatment of endothelial cells ( EC ) with sulforaphane ( 1-4 muM ) suppressed *induced* [MCP-1] and VCAM-1 mRNA and protein levels , but had no effect on TNF-alpha induced ICAM-1 expression . Positive_regulation CCL2 TNF 19339605 2056687 [MCP-1] *upregulation* by was dose dependently inhibited by the JNK inhibitors SP600125 ( anthra [ 1,9-cd ] pyrazol-6 ( 2H ) -one ) and D-JNKI-1 . Positive_regulation CCL2 TNF 1937574 170354 These data suggest that IL-1 and *induce* astrocytes to produce IL-8 and [MCAF] transcriptionally and post-transcriptionally , both of which may be responsible for leucocytosis seen in inflammation of the CNS . Positive_regulation CCL2 TNF 19410078 2075255 The study assessed the effect of simvastatin on *induced* synthesis of Cyr61 and [CCL2] in MG-63 human osteoblastic cells . Positive_regulation CCL2 TNF 19410078 2075258 Simvastatin also reduced the levels of *induced* [CCL2] , and exogenous Cyr61 restored the inhibitory effects . Positive_regulation CCL2 TNF 19426980 2157192 [MCP-1] is expressed in HUVECs in *response* to several different stimuli , including interleukin (IL)-1beta and . Positive_regulation CCL2 TNF 19426980 2157194 [MCP-1] expression was *regulated* by IL-1beta and and cytokine induced PREB expression . Positive_regulation CCL2 TNF 19429670 2106816 We examined the mechanism of Ang II-induced and/or *induced* [MCP-1] production from 3T3-L1 preadipocytes . Positive_regulation CCL2 TNF 19429670 2106817 The [MCP-1] protein and MCP-1 mRNA expression in 3T3-L1 preadipocytes were *increased* significantly by stimulation with . Positive_regulation CCL2 TNF 19429670 2106818 but it enhanced the *induced* [MCP-1] mRNA expression in a dose dependent manner . Positive_regulation CCL2 TNF 19429670 2106897 The [MCP-1] mRNA expression *induced* by and co-stimulation with Ang II was inhibited by either ERK inhibitor , p38MAPK inhibitor or NF-kappaB inhibitor . Positive_regulation CCL2 TNF 19429670 2106933 Our results suggest that Ang II may serve as an additional stimulus on the *induced* [MCP-1] production through the ERK-and p38MAPK dependent pathways probably due to AP-1 activation . Positive_regulation CCL2 TNF 19439823 2090482 Furthermore , these data suggested that [MCP-1] was *regulated* by and IL-1beta , and activated by both cytokines and biomaterials . Positive_regulation CCL2 TNF 19454709 2084583 Despite receptor expression , IL-17 was relatively ineffective at eliciting glial activation , whereas the cytokine augmented the ability of to *induce* CXCL2 and [CCL2] expression by macrophages . Positive_regulation CCL2 TNF 19454717 2084606 Furthermore , down-regulation of C/EBPbeta by small interfering RNA substantially reversed the suppressive effect of CsA on *induced* [MCP-1] expression . Positive_regulation CCL2 TNF 19458908 2115464 *induced* [MCP-1] , RANTES , and granzyme B production in cultured synovial cells from RA patients . Positive_regulation CCL2 TNF 19472186 2085575 , but not TPA , *increased* IL-6 and [MCP-1] mRNA levels , Next , we investigated the effects of ligands which activate c/nPKC . Positive_regulation CCL2 TNF 19563733 2121994 Furthermore , *induced* [MCP-1] and IL-8 mRNA expression levels were also attenuated by pretreatment with EZS . Positive_regulation CCL2 TNF 19577550 2117558 This study aims to test the ability of IL-1beta and to *stimulate* [CCL2] and CCL7 protein production in rat astrocyte cultures , and to elucidate signaling pathways involved in the cytokine stimulated chemokine upregulation . Positive_regulation CCL2 TNF 19607809 2123909 Both OA-NO ( 2 ) and LNO ( 2 ) prevented *stimulated* release of the cytokines , IL-6 , IL-8 , IL-12/p40 , IFNgamma , [MCP-1] , and IP-10 , and inhibited NF-kappaB activation . Positive_regulation CCL2 TNF 19666844 2138693 *upregulates* the expression of [monocyte chemoattractant protein-1] ( MCP-1 ) and adhesion molecules in type 2 diabetes . Positive_regulation CCL2 TNF 19776225 2232017 In contrast , overexpression of 11 beta-HSD1 further augmented *induced* iNOS , IL-6 , and [MCP-1] expression . Positive_regulation CCL2 TNF 19801900 2148233 Furthermore , vaspin did not decrease the ( 24 hr ) *induction* of vascular cell adhesion molecule-1 , intercellular adhesion molecule-1 , endothelial selectin , and cyclooxygenase-2 protein expression as well as [monocyte chemotactic protein-1] , tissue factor , and plasmogen activator inhibitor-1 mRNA expression . Positive_regulation CCL2 TNF 20042671 2200545 stimulated ChTRase release only from alveolar macrophages from smokers with COPD , and exposure of these cells to ChTRase *promoted* the release of IL-8 , [monocyte-chemoattractant protein-1] , and metalloproteinase-9 . Positive_regulation CCL2 TNF 20069129 2177869 In this study , we found that ticlopidine dose-dependently decreased the mRNA and protein levels of *stimulated* [MCP-1] , IL-8 , and vascular cell adhesion molecule-1 ( VCAM-1 ) in human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation CCL2 TNF 20069129 2177872 These results suggest that ticlopidine decreased *induced* [MCP-1] , IL-8 , and VCAM-1 levels in HUVECs , and monocyte adhesion . Positive_regulation CCL2 TNF 20153843 2236129 In addition , *induced* expression of inflammatory cytokines , [CCL2/MCP-1] and CXCL1/KC , was clearly inhibited by Licochalcone A but not reduced Licochalcone A . Positive_regulation CCL2 TNF 2033076 159611 These data are consistent with the *induction* of [MCP-1] expression from A549 cells by and IL-1 . Positive_regulation CCL2 TNF 20404154 2255861 In cultured rodent astrocytes , E2 or an ERalpha agonist , but not an ERbeta agonist , inhibits *induced* [CCL2] expression at nanomolar concentrations , and the ER antagonist ICI 182,170 blocks this effect . Positive_regulation CCL2 TNF 20406462 2255946 Moreover , the availability of p53 is apparently important for chemokine regulation , since can *induce* [MCP-1] only in human keratinocytes expressing the viral oncoprotein E7 , but not in HPV16 E6 positive cells , where p53 becomes degraded . Positive_regulation CCL2 TNF 20435921 2288104 TBP and TNF-SHARC dose-dependently inhibited *induced* secretion of interleukin (IL)-6 , IL-8 , granulocyte macrophage-colony stimulating factor , and [monocyte chemoattractant protein-1] in immortalized human endometriotic cells . Positive_regulation CCL2 TNF 20473515 2288567 IL-6 release into the medium was increased > 50-fold over 24 h with LPS and TNFalpha , while [MCP-1] release was *increased* 23- and 40-fold by and LPS , respectively . Positive_regulation CCL2 TNF 20478392 2307654 Conditioned medium from infected monocytes induced the secretion of IL-8 and/or [MCP-1] by A549 and Calu-6 cells , and these effects were mainly *mediated* by IL-1 ( in A549 cells ) or ( in Calu-6 cells ) . Positive_regulation CCL2 TNF 20515643 2327483 In differentiating 3T3-F442A adipocytes , fucoxanthinol , which is a fucoxanthin metabolite found in WAT , attenuated *induced* [MCP-1] and IL-6 mRNA overexpression and protein secretion into the culture medium . Positive_regulation CCL2 TNF 20557886 2308774 Q-real-time PCR and protein array approaches confirmed that *induced* ICAM-1 , VCAM-1 and ELAM-1 as well as [MCP-1] and IL-6 induction was affected upon 3beta-Adiol pre-incubation . Positive_regulation CCL2 TNF 20576301 2302964 Effect of live Lactobacillus plantarum L2 on *induced* [MCP-1] production in Caco-2 cells . Positive_regulation CCL2 TNF 20580034 2315903 Epigallocatechin gallate mediated protection against *induced* [monocyte chemoattractant protein-1] expression is heme oxygenase-1 dependent . Positive_regulation CCL2 TNF 20593161 2309247 It also reduced *induced* [MCP-1] ( also known as CCL2 ) , VCAM1 , ICAM1 and E-selectin mRNA expression . Positive_regulation CCL2 TNF 20609399 2321709 In the mouse whole blood ( MWB ) assay , *induced* KC and [CCL2] levels and also LPS induced interleukin-6 (IL-6) , CCL2 , and KC levels in MWB from ASK1 KO were significantly lower than those from WT . Positive_regulation CCL2 TNF 20663893 2317037 Both natural and synthetic PPAR? agonists potently inhibited RANTES ( regulated upon activation , normal T cell expressed and secreted ) and [monocyte chemoattractant protein-1] expression *induced* by in mesangial cells , which was dependent on NF-?B signaling . Positive_regulation CCL2 TNF 20851151 2368663 Relaxin treatment suppressed significantly *induced* upregulation of VCAM-1 and PECAM , CCR-2 , and [MCP-1] levels and direct monocyte adhesion to HUVEC . Positive_regulation CCL2 TNF 20943792 2347873 Quercetin , and to a lesser extent trans-RSV , attenuated the *induced* expression of inflammatory genes such as interleukin (IL)-6 , IL-1ß , IL-8 , and [monocyte chemoattractant protein-1] ( MCP-1 ) and the secretion of IL-6 , IL-8 , and MCP-1 . Positive_regulation CCL2 TNF 20977889 2348821 Rho-kinase mediates *induced* [MCP-1] expression via p38 MAPK signaling pathway in mesangial cells . Positive_regulation CCL2 TNF 20977889 2348822 However , its role in [MCP-1] *induction* by has not been elucidated . Positive_regulation CCL2 TNF 20977889 2348823 In the present study , we investigated whether the Rho/Rho-kinase signaling pathway regulates the *mediated* induction of [MCP-1] in mesangial cells . Positive_regulation CCL2 TNF 20977889 2348827 In agreement with this concept , Y-27632 , a specific Rho-kinase inhibitor , attenuated *mediated* induction of [MCP-1] . Positive_regulation CCL2 TNF 20977889 2348841 Based on these data we infer that Y-27632 inhibits *induced* [MCP-1] expression , secretion and function through inhibition of Rho-kinase and p38 MAPK activity . Positive_regulation CCL2 TNF 21036166 2365494 Intracellular transfer of an inhibitory anti-Cx32 monoclonal antibody significantly enhanced TNF-a induced monocyte chemotactic protein (MCP)-1 and IL-6 expression , but overexpression of Cx32 abrogated *induced* [MCP-1] and IL-6 expression . Positive_regulation CCL2 TNF 21186817 2378856 p-Coumaric acid , quercetin , and resveratrol demonstrated inhibitions of *induced* changes in levels of [monocyte chemoattractant protein-1] ( MCP-1 ) , plasminogen activator inhibitor-1 ( PAI-1 ) , and intracellular reactive oxygen species ( ROS ) in 3T3-L1 adipocytes . Positive_regulation CCL2 TNF 21367920 2420678 DHA and EPA decreased *stimulated* [MCP-1] mRNA expression by decreasing transcription of the MCP-1 gene . Positive_regulation CCL2 TNF 21367920 2420679 We conclude that DHA and EPA inhibit *stimulated* transcription of the [MCP-1] gene through interaction of signaling pathways involving ERK and NF-?B . Positive_regulation CCL2 TNF 21544387 407750 We compared the in vitro effects of various cytokines on the expression of monocyte chemoattractant protein-1 ( MCP-1 ) in glioma cell lines and found that [MCP-1] expression was highly *induced* by and interleukin-1 beta . Positive_regulation CCL2 TNF 21626431 2454635 Indeed , levosimendan increased cyclic guanosine monophosphate ( cGMP ) in human umbilical vein endothelial cells ( HUVECs ) and impaired the *induced* inflammatory expression of E-selectin , intercellular adhesion molecule-1 ( ICAM-1 ) , cyclooxygenase-2 (COX-2) , and [monocyte chemotactic protein-1 (MCP-1)] . Positive_regulation CCL2 TNF 21712071 2465763 Furthermore , increased [MCP-1] in the DRG is *induced* by and has no effect on the infiltration of macrophages into the DRG following L5 VR . Positive_regulation CCL2 TNF 2182712 131883 and LPS , unlike IL-6 , also *induced* [MCAF/MCP-1/TDCF] gene expression . Positive_regulation CCL2 TNF 22183741 2617279 In addition , treatment of endometriotic stromal cells with curcumin markedly inhibited *induced* secretion of IL-6 , IL-8 and [MCP-1] . Positive_regulation CCL2 TNF 22293775 2551795 ?-tocotrienol effectively improved the *induced* adverse changes in MCP-1 , IL-6 and adiponectin secretion , and in [MCP-1] , IL-6 , adiponectin and PPAR? mRNA expression . Positive_regulation CCL2 TNF 22393384 2566694 Interestingly , could *stimulate* the production of [CCL2/MCP-1] . Positive_regulation CCL2 TNF 22427564 2588225 significantly *increased* the expression of IL-6 , IL-8 , and [MCP-1] in ARPE-19 cells at both the protein and mRNA levels . Positive_regulation CCL2 TNF 22427566 2588230 *increased* the expression and secretion of IL-6 and [Ccl2] in ARPE-19 cells . Positive_regulation CCL2 TNF 22427566 2588232 In contrast , GPR109A ligands failed to suppress *induced* expression and secretion of IL-6 and [Ccl2] in primary RPE cells from Gpr109a ( -/- ) mice , confirming that the observed anti-inflammatory effects were mediated specifically by Gpr109a . Positive_regulation CCL2 TNF 22475809 2696788 Moreover , EPA attenuated *induced* [MCP-1] and further reduced its secretion in the presence of an NF-?B inhibitor . Positive_regulation CCL2 TNF 22561123 2608702 In addition , corilagin inhibits *induced* secretion of [MCP-1] and RANTES , exhibiting low or no effect on the release of G-CSF , IL-6 and VEGF . Positive_regulation CCL2 TNF 22611924 2603792 [ Effects of citreoviridin on the expression of [MCP-1] and ILs *induced* by in vein endothelial cells ] . Positive_regulation CCL2 TNF 22661092 2615443 RXR agonists also prevented *induced* VCAM-1 and ICAM-1 expression , as well as endothelial growth related oncogene-a and [MCP-1] release . Positive_regulation CCL2 TNF 22711527 2670027 Apoptosis signal regulating kinase 1 is mediated in *induced* [CCL2] expression in human synovial fibroblasts . Positive_regulation CCL2 TNF 22711527 2670028 Here , we investigated the intracellular signaling pathways involved in *induced* [monocyte chemoattractant protein 1] ( MCP-1 ) /CCL2 expression in human synovial fibroblast cells . Positive_regulation CCL2 TNF 22711527 2670029 Stimulation of synovial fibroblasts ( OASF ) with *induced* concentration- and time dependent increases in [CCL2] expression . Positive_regulation CCL2 TNF 22711527 2670030 *mediated* [CCL2] production was attenuated by TNFR1 monoclonal antibody ( Ab ) . Positive_regulation CCL2 TNF 22711527 2670040 Our results suggest that the interaction between and TNFR1 *increases* [CCL2] expression in human synovial fibroblasts via the ASK1 , JNK/p38 , c-Jun , and AP-1 signaling pathway . Positive_regulation CCL2 TNF 22895606 2672052 Tacrolimus ( FK506 ) suppresses *induced* [CCL2] ( MCP-1 ) and CXCL10 ( IP-10 ) expression via the inhibition of p38 MAP kinase activation in human colonic myofibroblasts . Positive_regulation CCL2 TNF 23295714 2752459 Sevoflurane suppressed *induced* IL-6 , IL-8 , and [MCP-1] gene expression and the production of IL-6 and IL-8 in SAEC under anoxia/reoxygenation conditions . Positive_regulation CCL2 TNF 23319318 2733163 We have investigated whether MPA regulates Syk to repress *induced* [MCP-1] production in cultured human aortic endothelial cells . Positive_regulation CCL2 TNF 23319318 2733164 *increased* [MCP-1] at both mRNA and protein levels . Positive_regulation CCL2 TNF 23319318 2733168 *induced* [MCP-1] mRNA expression was inhibited by N-acetylcysteine (NAC) , Syk inhibitor , Syk-siRNA and MPA . Positive_regulation CCL2 TNF 23319318 2733171 *induced* [MCP-1] protein production was also inhibited by Syk inhibitor and MPA . Positive_regulation CCL2 TNF 23319318 2733172 TNF-a increased DNA binding activity of AP-1 and NF-?B , whereas both AP-1 and NF-?B decoy oligodeoxynucleotides downregulated *induced* [MCP-1] mRNA expression . Positive_regulation CCL2 TNF 23319318 2733178 *induced* [MCP-1] expression via activation of AP-1 and NF-?B . Positive_regulation CCL2 TNF 23460644 2776485 [CCL2] in bEnd.3 cells was more prominently *up-regulated* by compared with IFN-? . Positive_regulation CCL2 TNF 23607100 2774557 GW501516 also significantly attenuated *mediated* expression of [MCP-1] . Positive_regulation CCL2 TNF 23611379 2774617 Simvastatin and FoxO3a diminished *induced* [CCL2] secretion and macrophage recruitment , whereas Cyr61 partially restored the stimulating action . Positive_regulation CCL2 TNF 23760613 2887305 In addition , 6-MSITC reduced *induced* interleukin-6 and [monocyte chemoattractant protein-1] expression . Positive_regulation CCL2 TNF 23803215 2808017 Exendin-4 has an intrinsic capability to concentration- and time-dependently inhibit *induced* expression of [MCP-1] and FN in rat mesangial cells , suggesting the beneficial effect of exendin-4 in preventing and treating diabetic nephropathy . Positive_regulation CCL2 TNF 24028188 2842174 Cdc42 GTPases facilitate *mediated* secretion of [CCL2] from peripheral nerve microvascular endoneurial endothelial cells . Positive_regulation CCL2 TNF 24028188 2842175 We sought to determine the mechanism by which *induces* expression and secretion of [CCL2] from peripheral nerve microvascular endoneurial endothelial cells ( PNMECs ) . Positive_regulation CCL2 TNF 24028188 2842177 Simvastatin significantly attenuated *induced* [CCL2] secretion without affecting CCL2 mRNA or protein expression . Positive_regulation CCL2 TNF 24028188 2842178 Inhibition of the monomeric GTPase Cdc42 , but not Rac1 or RhoA-C , attenuated *mediated* [CCL2] secretion . Positive_regulation CCL2 TNF 24037783 2885405 Moreover , treatment with isoproterenol markedly suppressed the *induced* increase of [CCL2] mRNA expression and CCL2 production through a ß-adrenergic receptor-PKA pathway mediated by GSK-3ß regulation . Positive_regulation CCL2 TNF 24333549 2910824 Our results showed that tumor necrosis factor-alpha ( TNF-a ) significantly increased the protein or mRNA levels of monocyte chemotactic protein-1 (MCP-1) , intercellular adhesion molecule-1 ( ICAM-1 ) , and vascular cell adhesion molecule-1 ( VCAM-1 ) , whereas pretreatment with Malvidin inhibited *induced* increases of [MCP-1] , ICAM-1 , and VCAM-1 production in a concentration dependent manner . Positive_regulation CCL2 TNF 24491567 2923635 On the other hand , the stimulation with , which osteoclasts were able to release , significantly *enhanced* [MCP-1] secretion ( p < 0.01 ) , but had no effect on VEGF120 . Positive_regulation CCL2 TNF 24534785 2942603 AKF-PD significantly inhibited *induced* expression of interleukin-6 , [monocyte chemoattractant protein-1] and interleukin-8 and nuclear translocation of p65 in HK-2 cells . Positive_regulation CCL2 TNF 24699803 2938769 In ARPE-19 cells , *induced* proinflammatory gene expression of interleukin (IL)-1ß , IL-6 , and [monocyte chemotactic protein-1] was decreased by 35.0 % , 68.8 % , and 62.5 % , respectively , with MGP pretreatment , which was primarily due to the diminished mitogen activated protein kinase activation and subsequent reduction of nuclear factor ?-B activation . Positive_regulation CCL2 TNF 2471522 111768 This is the first report of the *induction* of [MCAF] by IL 1 or in any cell type . Positive_regulation CCL2 TNF 24719782 2932010 *induced* [CCL2] , CCL7 , and CXCL1 in preadipocytes but had no response in adipocytes . Positive_regulation CCL2 TNF 24777714 2950239 Furthermore , expressions of and monocyte chemoattractant protein (MCP)-1 messenger ( m ) RNA in U87 and C6 cells were detected by an RT-PCR , and TNF-a and [MCP-1] *induced* iNOS protein expression in time- and concentration dependent manners . Positive_regulation CCL2 TNF 7523503 272212 IL-1 and stimulation also can *induce* low levels of [MCP-1] production . Positive_regulation CCL2 TNF 7642742 318054 Lipopolysaccharide (LPS) , interleukin (IL)-1 beta and *induced* [MCP-1] secretion by astrocytes , but not microglia . Positive_regulation CCL2 TNF 7811465 292535 We determined that stimulation of resident rat PAMs with bacterial lipopolysaccharide (LPS) , murine , or human interleukin-1 beta *resulted* in the inducible expression of MCP-1 mRNA and the secretion of biologically active [MCP-1] . Positive_regulation CCL2 TNF 7942160 276330 [MCP-1] expression at both the protein and mRNA levels was greatly *increased* by IL-1 beta and . Positive_regulation CCL2 TNF 7942160 276332 At the mRNA level , IL-1 beta and strongly *induced* [MCP-1] expression ; Positive_regulation CCL2 TNF 7942299 243873 did not *cause* secretion of [MCP-1] , but caused about the same amount of NAP-1 secretion as IL-2 + IFN gamma . Positive_regulation CCL2 TNF 8063765 268792 Retinoic acid suppression of c-fos gene inhibits expression of *induced* monocyte chemoattractant [JE/MCP-1] in clonal osteoblastic MC3T3-E1 cells . Positive_regulation CCL2 TNF 8063765 268793 Our previous study ( Hanazawa , S. , Takeshita , A. , Amano , S. , Semba , T. , Nirazuka , T. , Katoh , H. , and Kitano , S. ( 1993 ) J. Biol. Chem. 268 , 9526-9532 ) demonstrated that *induces* monocyte chemoattractant [JE/MCP-1] expression via c-fos and c-jun genes following protein kinase C activation in osteoblastic MC3T3-E1 cells . Positive_regulation CCL2 TNF 8117936 241883 When various immunosuppressive drugs were tested , glucocorticoids but not other immunosuppressive drugs markedly inhibited the IL-1 or *induced* IL-8 and [MCAF] mRNA accumulation , suggesting that glucocorticoid is a potent regulator of these inflammatory cytokine production in the neural tissues . Positive_regulation CCL2 TNF 8178946 255844 Induction of [MCP-1] transcript by thrombin was not *reduced* by blocking interleukin-1 and , suggesting that these mediators are not involved in thrombin induced expression of MCP-1 . Positive_regulation CCL2 TNF 8301205 248712 Gamma interferon ( IFN-gamma ) , , and interleukin-1 (IL-1) markedly *stimulate* the release of [MCP-1] as measured by a specific and sensitive radioimmunoassay . Positive_regulation CCL2 TNF 8397228 230429 We conclude that generation of reactive oxygen species , possibly by NADPH dependent oxidase , are involved in the *induction* of the [JE/MCP-1] and CSF-1 genes by and IgG complexes . Positive_regulation CCL2 TNF 8408620 233307 also *increased* [MCP-1] secretion , although to a lesser extent ( 1.6-fold ) . Positive_regulation CCL2 TNF 8424834 210925 Use of cycloheximide and actinomycin D confirmed that was *inducing* [MCP-1] expression at both the transcriptional and translational levels . Positive_regulation CCL2 TNF 8424834 210927 These studies demonstrate that the [MCP-1] gene is *regulated* by and IFN gamma in type B synoviocytes and indicate that these cells may play an important role in the recruitment of inflammatory cells to the rheumatoid synovial environment , via the production of novel chemotactic cytokines such as MCP-1 . Positive_regulation CCL2 TNF 8482848 218869 Northern blot analysis revealed that IL-1 and *stimulated* [MCP-1] mRNA expression in a dose dependent manner , whereas dexamethasone blocked MCP-1 expression by cells stimulated with IL-1 . Positive_regulation CCL2 TNF 8507217 221500 Fibroblast-like synoviocytes were found to express MCAF mRNA and to secrete [MCAF] in *response* to interleukin-1 (IL-1) and in vitro . Positive_regulation CCL2 TNF 8587246 341586 Northern blot analysis revealed that MCP-1 mRNA was constitutively expressed by GEN and that IL-1 beta and *increased* [MCP-1] mRNA levels in a dose- and time dependent manner . Positive_regulation CCL2 TNF 8587246 341588 Inhibition study using protein kinase inhibitors revealed that [MCP-1] mRNA expression *induced* by IL-1 beta and was suppressed by the tyrosine kinase inhibitor genistein , not by the protein kinase C inhibitors staurosporine or H-7 , or the protein kinase A inhibitor H-89 , suggesting an important role of tyrosine kinase in the cytokine induced MCP-1 gene expression . Positive_regulation CCL2 TNF 8757628 377754 Finally , we provide evidence that the Abeta ( 25-35 ) - and Abeta plus IFN-gamma induced production of [MCP-1] is , in large part , *mediated* in an autocrine fashion by endogenous . Positive_regulation CCL2 TNF 8793801 381095 This study examined the role of *mediated* cellular signal transduction pathways on mesangial cell [MCP-1] gene expression and monocyte migration . Positive_regulation CCL2 TNF 8793801 381096 Similarly , calphostin C , a PKC inhibitor , failed to inhibit *induced* [MCP-1] expression . Positive_regulation CCL2 TNF 8793801 381097 However , the coincubation of mesangial cells with TNF-alpha and dbcAMP completely inhibited *induced* [MCP-1] gene expression . Positive_regulation CCL2 TNF 8793801 381098 *induced* mesangial cell [MCP-1] expression is regulated by signal transduction pathways involving PTK but not those dependent on PKC or cAMP . Positive_regulation CCL2 TNF 8832978 385873 Antioxidants inhibit *mediated* stimulation of interleukin-8 , [monocyte chemoattractant protein-1] , and collagenase expression in cultured human synovial cells . Positive_regulation CCL2 TNF 8832978 385875 *increased* the expression of IL-8 , [MCP-1] , and collagenase mRNA in human synovial cells . Positive_regulation CCL2 TNF 8832978 385877 Our data suggest that *induces* expression of proinflammatory cytokines such as IL-8 and [MCP-1] through generation of reactive oxygen intermediates and subsequent activation of NF-kappa B in human synovial cells , and the antioxidants may inhibit , at least in part , the activation of NF-kappa B by TNF-alpha . Positive_regulation CCL2 TNF 8882622 390862 Ro 31-8220 also inhibited the expression of IL-1 alpha or *induced* [MCP-1] and RANTES mRNA with a similar potency . Positive_regulation CCL2 TNF 8895322 392454 Finally , interleukin-1 beta and ( 1-1000 pM ) *stimulated* dose dependent increases in the secretion of interleukin-6 and [monocyte chemoattractant protein-1] at 34 C and 40C . Positive_regulation CCL2 TNF 8941762 399321 Interleukin-1 beta and *stimulate* synergistically the expression of [monocyte chemoattractant protein-1] in fibroblastic cells derived from human periodontal ligament . Positive_regulation CCL2 TNF 8941762 399323 The present study demonstrates that interleukin-1 beta (IL-1 beta) and induce and synergistically *stimulate* [monocyte chemoattractant protein-1] ( MCP-1 ) expression in fibroblasts from human periodontal ligament . Positive_regulation CCL2 TNF 8943702 400117 In this study , we examined the ability of interleukin-7 to induce RPE derived monocyte chemotactic protein-1 and interleukin-8 and assessed the potentiating effects of interleukin-7 on interleukin-1 beta- and *induced* RPE [monocyte chemotactic protein-1] and interleukin-8 production . Positive_regulation CCL2 TNF 8943702 400129 Interleukin-7 potentiated *induced* RPE [monocyte chemotactic protein-1] steady-state mRNA expression at all doses of interleukin-7 while only high dose interleukin-7 ( 100 ng ml-1 ) enhanced tumor necrosis factor-alpha induced RPE interleukin-8 steady-state gene expression . Positive_regulation CCL2 TNF 8943702 400135 These studies suggest that interleukin-7 potentiation of interleukin-1 beta and *induced* RPE [monocyte chemotactic protein-1] and IL-8 may be important for the elicitation of leukocyte chemotaxins in diseased retinal tissue when only low ambient levels of individual pro-inflammatory cytokines are present . Positive_regulation CCL2 TNF 9024159 413320 Both ischemic ( but not preischemic ) cardiac lymph and human recombinant *induced* [MCP-1] in CJVECs . Positive_regulation CCL2 TNF 9040477 415865 To examine the modulation of interleukin-1 beta (IL-1 beta)- and *stimulated* [monocyte chemotactic protein-1 (MCP-1)] and interleukin-8 (IL-8) secretion and transcription in human retinal pigment epithelial ( HRPE ) cells by dexamethasone ( DEX ) and cyclosporin A ( CSA ) . Positive_regulation CCL2 TNF 9040477 415868 In contrast , CSA significantly inhibited *stimulated* , but not IL-1 beta stimulated , HRPE [MCP-1] and IL-8 secretion . Positive_regulation CCL2 TNF 9040477 415870 IL-1 beta induced chemokine secretion is sensitive to DEX , whereas [MCP-1] and IL-8 *induced* by are inhibited by CSA . Positive_regulation CCL2 TNF 9040478 415874 IFN-gamma induced dose dependent increases in HRPE MCP-1 , but not IL-8 , IFN-gamma potentiated IL-1 beta and *induced* [MCP-1] production , but showed little modulation of IL-1 beta and TNF-alpha induced IL-8 production . Positive_regulation CCL2 TNF 9077472 420390 Upon *stimulation* with interleukin-1beta (IL-1beta) and , both HDMECs and HMEC-1 expressed high levels of IL-8 , GRO , and [monocyte chemoattractant protein-1] ( MCP-1 ) . Positive_regulation CCL2 TNF 9130630 426882 Eosinophils generated immunoreactive [MCP-1] in response to such diverse stimuli as C5a , formyl-methionyl-leucyl-phenylalanine ( FMLP ) and ionomycin , but MCP-1 production was not *induced* by interleukin (IL)-1 or . Positive_regulation CCL2 TNF 9176445 433743 moreover , both interleukin-1 alpha and *induced* higher levels of [monocyte chemotactic protein-1] . Positive_regulation CCL2 TNF 9292787 452838 Quercetin , a bioflavonoid , inhibits the *induction* of interleukin 8 and [monocyte chemoattractant protein-1] expression by in cultured human synovial cells . Positive_regulation CCL2 TNF 9292787 452840 Quercetin suppresses *mediated* stimulation of IL-8 and [MCP-1] expression , at least in part , by inhibiting the activation of NF-kappa B . Positive_regulation CCL2 TNF 9301536 453931 In contrast to the synergistic effect of IL-13 and tumour necrosis factor-alpha (TNF-alpha) on endothelial vascular cell adhesion molecule-1 ( VCAM-1 ) surface expression , *induced* secretion of [MCP-1] is not augmented by IL-13 . Positive_regulation CCL2 TNF 9375973 465367 IL-13 , but not IL-10 , significantly enhanced IL-8 and [MCP-1] release in *response* to IL-1alpha or . Positive_regulation CCL2 TNF 9376623 465518 MKN28 cells were found to secrete [MCP-1] in *response* to IL-1 beta or in a dose- and time dependent manner . Positive_regulation CCL2 TNF 9405974 470409 Cilostazol , a cAMP phosphodiesterase inhibitor , attenuates the production of [monocyte chemoattractant protein-1] in *response* to in vascular endothelial cells . Positive_regulation CCL2 TNF 9407069 470802 While *induced* both RANTES and [MCP-1] , H2O2 induced only MCP-1 . Positive_regulation CCL2 TNF 9407497 470982 This sequence of *induced* [MCP-1] and RANTES expression was confirmed on the protein level . Positive_regulation CCL2 TNF 9441701 475950 Dose- and time dependent RPE cell [MCP-1] secretion was also *observed* following IL-1 beta > > IFN-gamma stimulation , with an average of 4 % of the total MCP-1 retained within RPE . Positive_regulation CCL2 TNF 9520946 493673 In contrast to IL-8 , the *induced* HRPE [MCP-1] gene expression was only slightly enhanced by GHSA . Positive_regulation CCL2 TNF 9610617 508784 and LPS also *induced* [MCP-1] and ICAM-1 gene expression . Positive_regulation CCL2 TNF 9620670 510583 can *stimulate* [MCP-1] production and is also present within ovarian carcinomas . Positive_regulation CCL2 TNF 9647253 515000 Exposure of cultured rat mesangial cells to AngII *increased* [MCP-1] mRNA expression ( 2.7-fold ) and synthesis ( 3-fold ) , similar to that observed with . Positive_regulation CCL2 TNF 9657919 516872 IL-1beta and synergistically *induced* IL-6 and GM-CSF and additively induced IL-8 and [MCP-1] production , while IL-2 , IL-10 , IFN-alpha , and IFN-gamma had little or no additional effects . Positive_regulation CCL2 TNF 9714185 527667 Thus , the production of [MCP-1] in LPS induced arthritis was mostly *regulated* by and IL-1 , whereas half the extent of MCP-1 production in MSU crystal induced arthritis was independent of TNFalpha or IL-1 . Positive_regulation CCL2 TNF 9822259 548708 *induced* [MCP-1] , RANTES and MIP-1beta mRNA expression , and lipopolysaccharide (LPS) induced MCP-1 , MIP-1alpha and MIP-1beta mRNA expression in astrocytes . Positive_regulation CCL2 TNF 9822259 548719 TGF-beta1 and IL-10 also down-regulated [MCP-1] and RANTES mRNA expression *induced* by . Positive_regulation CCL2 TNF 9825772 549212 Both chemokines were produced in response to IL-1alpha by SK-N-SH cells , while *induced* mainly [MCP-1] production . Positive_regulation CCL2 TNF 9916692 587481 transcriptionally *regulates* murine [monocyte chemoattractant protein-1] ( MCP-1 ) expression . Positive_regulation CCL2 TNF 9916692 587484 Trans-activation studies conducted by cotransfection of p50 and/or p65 expression vectors with MCP-1 constructions showed that *regulates* [MCP-1] through NF-kappa B . Positive_regulation CCL2 TNF 9916692 587486 This study illustrates the crucial role for NF-kappa B p65 in the *induction* of the [MCP-1] gene by and in the assembly of a NF-kappa B dependent enhancer in vivo . Positive_regulation CCL2 TNF 9920834 588005 The MKK6/p38 stress kinase cascade is critical for *induced* expression of [monocyte-chemoattractant protein-1] in endothelial cells . Positive_regulation CCL2 TNF 9920834 588006 Contribution of MAP kinase pathways to *induced* synthesis of endothelial [MCP-1] was then studied by pharmacologic inhibition and transient expression of dominant negative or constitutively active kinase mutants using flow cytometry , Northern blot , and luciferase reporter gene assays . Positive_regulation CCL2 TNF 9920834 588008 Inhibition of Raf/MEK/ERK or SEK/JNK pathways had no significant effect on MCP-1 levels , whereas blocking the MKK6/p38 pathway by p38 inhibitors SB203580 or SB202190 or by a dominant negative mutant of MKK6 , the upstream activator of p38 , strongly inhibited *induced* expression of [MCP-1] . Positive_regulation CCL2 TNF 9920834 588010 These data suggest a crucial role for the MKK6/p38 stress kinase cascade in *mediated* endothelial [MCP-1] expression . Positive_regulation CCL2 TNF 9927154 588427 [Monocyte chemotactic protein-1] was *inducible* by in non transformed hepatic stellate cells . Positive_regulation CCL2 TNF 9950608 589838 MG-132 suppressed MGSA/gro-alpha , RANTES , MCP-1 , IL-1beta , M-CSF , and ICAM-1 mRNA expression and secreted RANTES , [MCP-1] , and M-CSF protein , and cell-surface ICAM-1 that were *induced* by IL-1beta , , and TII . Positive_regulation CCL2 TNFSF10 16227629 1483595 *induced* secretion of interleukin-8 and [monocyte chemoattractant protein-1] , augmenting macrophage migration . Positive_regulation CCL2 TNFSF10 16751802 1645922 Here , we show that strongly *induces* the expression of the proinflammatory cytokines interleukin-8 and [monocyte chemoattractant protein 1] and enhances the invasion of apoptosis-resistant pancreatic ductal adenocarcinoma cells in vitro by upregulation of the urokinase-type plasminogen activator expression . Positive_regulation CCL2 TNFSF10 18313665 1886030 *stimulated* production of several cytokines , IL-8 , RANTES , [MCP-1] and bFGF , and activation of caspases 1 and 8 was essential for this effect . Positive_regulation CCL20 EPHB2 16232215 1470379 On the other hand , we found that not only NF-kappaB , p38 MAPK and but also c-Jun NH2-terminal kinase (JNK) are *involved* in [CCL20] production induced by E. coli LPS . Positive_regulation CCL20 EPHB2 24557363 2919283 NF-?B inhibitor and inhibitor significantly *inhibited* IL-6 and [CCL20] productions from IL-1ß stimulated HPDLCs . Positive_regulation CCL20 IL1B 11472439 841473 Cultured synovial fibroblasts derived from either RA or OA patients were capable of producing [MIP-3 alpha] in *response* to and TNFalpha in vitro . Positive_regulation CCL20 IL1B 12356943 994158 Tumour necrosis factor-alpha and significantly *stimulated* the secretion of [MIP-3alpha] by HHUA and ESC . Positive_regulation CCL20 IL1B 12949243 1137084 CCL19 and [CCL20] mRNA expression was *up-regulated* by or tumor necrosis factor alpha (TNF-alpha) , and in addition , IFN-alpha together with TNF-alpha further enhanced CCL19 gene expression . Positive_regulation CCL20 IL1B 16232215 1470375 In contrast , interferon-gamma (IFN-gamma) dramatically diminished [CCL20] production *induced* by . Positive_regulation CCL20 IL1B 16232215 1470377 Moreover , we demonstrated that nuclear factor-kappaB (NF-kappaB) , p38 mitogen activated protein kinase (MAPK) and extracellular signal regulated kinases ( ERK ) play an important role in mediating the production of [CCL20] *induced* by and TNF-alpha . Positive_regulation CCL20 IL1B 16306769 1486468 Moreover , tumor necrosis factor-alpha- or *induced* [CCL20] secretion was greatly diminished by 5-aminosalicylic acid and/or glucocorticoid treatment of human intestinal epithelial HT-29 cells . Positive_regulation CCL20 IL1B 18025126 1827599 The [CCL20] production by synoviocytes is *augmented* in vitro by , IL-17 , or tumor necrosis factor alpha , and is suppressed by IFN-gamma or IL-4 . Positive_regulation CCL20 IL1B 19535263 2109679 The production of [CCL20] *induced* by TNF-alpha and was modified by helper-T-cell derived cytokines . Positive_regulation CCL20 IL1B 19797510 2159434 In contrast , interferon-gamma suppressed *induced* [CCL20] production . Positive_regulation CCL20 MMP28 22424696 2588106 inhibitor ( UK370106 ) *inhibited* the expression of [CCL20] induced by co-stimulation with fAd and IL-6 or TNF-a . Positive_regulation CCL20 MMP7 22424696 2588121 inhibitor ( UK370106 ) *inhibited* the expression of [CCL20] induced by co-stimulation with fAd and IL-6 or TNF-a . Positive_regulation CCL20 TLR7 24265691 2869791 Expression of [CCL20] is *induced* by signaling or proinflammatory cytokine stimulation . Positive_regulation CCL20 TNF 11472439 841472 Cultured synovial fibroblasts derived from either RA or OA patients were capable of producing [MIP-3 alpha] in *response* to IL-1 beta and in vitro . Positive_regulation CCL20 TNF 12023359 943738 *Induction* of [macrophage-inflammatory protein-3alpha] gene expression by dependent NF-kappaB activation . Positive_regulation CCL20 TNF 12023359 943743 [MIP-3alpha] transcription was *stimulated* by , and this stimulation was inhibited by an NF-kappaB inhibitor , I-kappaBalpha superrepressor . Positive_regulation CCL20 TNF 12642237 1069367 The expression of [MIP-3alpha] was upregulated by infection with Actinobacillus actinomycetemcomitans and by *stimulation* with lipopolysaccharide and . Positive_regulation CCL20 TNF 12695561 1081093 IL-1beta , IL-18 , and *stimulated* RA fibroblast [MIP-3alpha] production at 48 hours of incubation in vitro . Positive_regulation CCL20 TNF 12748059 1149485 Expression of [CCL20] transcripts were significantly *induced* by interleukin (IL)-1beta and , and inhibited by dexamethasone . Positive_regulation CCL20 TNF 12949243 1137083 CCL19 and [CCL20] mRNA expression was *up-regulated* by IL-1beta or , and in addition , IFN-alpha together with TNF-alpha further enhanced CCL19 gene expression . Positive_regulation CCL20 TNF 16155407 1455500 A pharmacologic study also revealed that multiple signaling pathways are differentially involved in CCL20 production by DFO , while some of those pathways are not involved in *induced* [CCL20] production . Positive_regulation CCL20 TNF 16232215 1470376 Moreover , we demonstrated that nuclear factor-kappaB (NF-kappaB) , p38 mitogen activated protein kinase (MAPK) and extracellular signal regulated kinases ( ERK ) play an important role in mediating the production of [CCL20] *induced* by IL-1beta and . Positive_regulation CCL20 TNF 16937467 1609114 DA-9601 , a standardized extract of Artemisia asiatica , blocks *induced* IL-8 and [CCL20] production by inhibiting p38 kinase and NF-kappaB pathways in human gastric epithelial cells . Positive_regulation CCL20 TNF 16937467 1609117 Treatment of AGS cells with DA-9601 reduced *induced* IL-8 and [CCL20] promoter activities , as well as their gene expression and protein release . Positive_regulation CCL20 TNF 17295217 1718762 Furthermore , UTP had no effect on interleukin-(IL)-8 release and reduced the release of both [CCL20] and IL-8 *induced* by and LPS . Positive_regulation CCL20 TNF 17619881 1815987 *induced* [MIP-3alpha] but not IL-23 production in cultured synovial cells from RA patients . Positive_regulation CCL20 TNF 19535263 2109674 IL-1beta vigorously induced the production of CCL20 from FLSs of human RA and the production of [CCL20] *induced* by was partially attributed to a trace amount of IL-1beta induced by TNF-alpha . Positive_regulation CCL20 TNF 19535263 2109678 The production of [CCL20] *induced* by and IL-1beta was modified by helper-T-cell derived cytokines . Positive_regulation CCL20 TNF 19924133 2217239 Furthermore , IL-27 alone greatly induced in vitro CXCL9 , CXCL10 , and CXCL11 production and tyrosine phosphorylation of signal transducer and activator of transcription 1 in normal human keratinocytes , while it suppressed the *induced* production of IL-1alpha and [CCL20] . Positive_regulation CCL20 TNF 20881253 2337378 IL-1ß , , and IL-17A *increased* the secretion of [CCL20] in cultured endometriotic stromal cells . Positive_regulation CCL20 TNF 21050487 2349348 [CCL-20] expression can be *increased* by and IL-1a . Positive_regulation CCL20 TNF 21673103 2455408 Visfatin enhanced *induced* CXC chemokine ligand (CXCL) 8 , CXCL10 , and [CC chemokine ligand (CCL) 20] secretion and mRNA expression in keratinocytes , although visfatin alone was ineffective . Positive_regulation CCL20 TNF 21824198 2477038 We demonstrated that IL-1ß , , and IL-17A significantly *increased* [CCL20] production from HaCaT cells . Positive_regulation CCL20 TNF 22424696 2588094 Adiponectin *induces* [CCL20] expression synergistically with IL-6 and in THP-1 macrophages . Positive_regulation CCL20 TNF 23178752 2718138 stimulation *enhanced* [CCL20] expression in hepatocytes . Positive_regulation CCL20 TNF 23239110 2745564 In RASFs , simvastatin suppressed the *induced* production of CYR-61 and [CCL20] . Positive_regulation CCL20 TNF 23800251 2808001 Finally , [CCL20] and CXCL8 responded synergistically in *response* to EGF and in OVCAR-3 and SKOV-3 cells . Positive_regulation CCL20 TNFSF10 17934471 1819733 Recombinant induces pathognomic features of asthma and *stimulates* the production of [CCL20] in primary human bronchial epithelium cells . Positive_regulation CCL20 TNFSF10 19120450 2019359 In this article , it is shown that *induces* CXCL2 , CCL4 and [CCL20] secretion in a nuclear factor kappa B-dependent manner . Positive_regulation CCL21 ANGPT1 21225692 2408982 CCL19 and [CCL21] activation *induced* vascular endothelial growth factor and angiotensin I (Ang I) production in RA ST fibroblasts and secretion of IL-8 and from macrophages . Positive_regulation CCL21 PECAM1 24009720 2836871 PI3K p110d is expressed by gp38 ( - ) ( + ) and gp38 ( + ) CD31 ( + ) spleen stromal cells and *regulates* their CCL19 , [CCL21] , and LTßR mRNA levels . Positive_regulation CCL21 TNF 20126461 2207223 TWEAK , but not used as control ) , *induced* a delayed increase in CCL21a mRNA ( 3.5+/-1.22-fold over control ) and [CCL21] protein ( 2.5+/-0.8-fold over control ) , which was prevented by inhibition of the proteasome , or siRNA targeting of NIK or RelB , but not by RelA inhibition with parthenolide . Positive_regulation CCL22 TNF 11352815 814885 In addition , *induced* [MDC/CCL22] secretion was differentially modulated by Th1 and Th2 cytokines . Positive_regulation CCL22 TNF 24704449 2935404 Furthermore , we showed that PKC? and p38 MAPK contributed to the inhibition of *induced* TARC/CCL17 and [MDC/CCL22] expression by blocking I?Ba degradation in HaCaT cells . Positive_regulation CCL22 TNF 24704449 2935407 Taken together , these results suggest that ( + ) -nootkatone may suppress *induced* TARC/CCL17 and [MDC/CCL22] expression in HaCaT cells by inhibiting of PKC? and p38 MAPK signaling pathways that lead to activation of NF-?B . Positive_regulation CCL23 IL1B 9187369 437040 [CKbeta8] mRNA transcripts were *induced* in monocytes by and , to a lesser extent , by IFNgamma , and were detected in RNA extracted from normal human liver and gastrointestinal tract . Positive_regulation CCL23 TNF 23331383 2803495 In addition , the IL-1ß- and *stimulated* [MIP-3a] production was potently reduced by the MAPK and NF?B signaling pathway inhibitors . Positive_regulation CCL23 TNF 23331383 2803523 Interleukin-1ß and *increased* the [MIP-3a] production in SFCs via the MAPK and NF?B pathways . Positive_regulation CCL26 IL1B 20059579 2241572 Tumour necrosis factor-alpha (TNF-alpha) and alone did not *induce* [CCL26] expression , yet these pro-inflammatory cytokines synergized with IL-4 to increase CCL26 protein expression . Positive_regulation CCL26 TNF 12061839 952943 Unlike Eotaxin-1 , [Eotaxin-3] mRNA expression was not *induced* by either or interleukin (IL)-1 beta alone . Positive_regulation CCL26 TNF 16755001 1571590 We observed that a human lung fibroblast , HFL-1 produces [eotaxin-1 and -3] in *response* to plus IL-4 stimulation , accompanied with NF-kappaB and STAT6 activation . Positive_regulation CCL26 TNF 17073866 1637966 Dermal fibroblasts produced eotaxin and [eotaxin-3] in *response* to stimulation by interleukin (IL)-4 and/or . Positive_regulation CCL26 TNF 20059579 2241571 and interleukin-1beta (IL-1beta) alone did not *induce* [CCL26] expression , yet these pro-inflammatory cytokines synergized with IL-4 to increase CCL26 protein expression . Positive_regulation CCL27 IL1B 11821900 908899 Tumor necrosis factor-alpha and *induced* [CCL27] production whereas the glucocorticosteroid clobetasol propionate suppressed it . Positive_regulation CCL27 TNF 11821900 908898 and interleukin-1beta *induced* [CCL27] production whereas the glucocorticosteroid clobetasol propionate suppressed it . Positive_regulation CCL27 TNF 15335355 1291145 TARC augments *induced* [CTACK] production in keratinocytes . Positive_regulation CCL27 TNF 15335355 1291146 We found that [CTACK] can be *induced* in cultured human keratinocytes by , but not by TARC alone . Positive_regulation CCL27 TNF 15577845 1344729 *increased* [CCL27] secretion and mRNA levels in parallel to NF-kappaB activity in keratinocytes . Positive_regulation CCL27 TNF 15577845 1344731 NF-kappaB p50 or p65 antisense oligonucleotides suppressed *induced* [CCL27] production , indicating the requirement of NF-kappaB for CCL27 production . Positive_regulation CCL27 TNF 15577845 1344733 PGE ( 2 ) , EP2 , or EP3 agonists reduced *induced* [CCL27] secretion and mRNA levels in parallel to NF-kappaB activity and CCL2 , CCL5 , CXCL8 , and CXCL10 mRNA levels . Positive_regulation CCL27 TNF 15598438 1356639 *induced* [CTACK/CCL27] ( cutaneous T-cell attracting chemokine ) production in keratinocytes is controlled by nuclear factor kappaB . Positive_regulation CCL27 TNF 15598438 1356640 [CCL27] can be *induced* in cultured keratinocytes by , which is also known to induce activity of the transcription factor NF-kappaB . Positive_regulation CCL27 TNF 15598438 1356644 We show here that inhibition of NF-kappaB with the non-specific NF-kappaB inhibitors SSC ( sodium salicylate ) , DCIC ( 3,4-dichloroisocoumarin ) and PAO ( phenylarsine oxide ) results in a downregulation of *induced* [CCL27] production . Positive_regulation CCL27 TNF 15598438 1356648 Inhibition of either p50 or p65 production with antisense oligonucleotides resulted in a significant downregulation of *induced* [CCL27] production . Positive_regulation CCL27 TNF 16275389 1480093 IL-17 suppresses *induced* [CCL27] production through induction of COX-2 in human keratinocytes . Positive_regulation CCL27 TNF 16275389 1480096 We examined the in vitro effects of IL-17 on *induced* [CCL27] production in human keratinocytes . Positive_regulation CCL27 TNF 16275389 1480103 IL-17 suppressed *induced* [CCL27] secretion and mRNA expression and NF-kappaB activity in keratinocytes . Positive_regulation CCL27 TNF 16275389 1480147 IL-17 might suppress *induced* [CCL27] production by inhibiting NF-kappaB through induction of COX-2 . Positive_regulation CCL27 TNF 16433680 1516281 In this study , we showed that [CCL27] and CCL28 expression and production by a human keratinocyte cell line , HaCaT cells , were strongly *induced* by inflammatory cytokines and interleukin-1beta . Positive_regulation CCL27 TNF 16784723 1585633 Suppressive effects of antimycotics on *induced* [CCL27] , CCL2 , and CCL5 production in human keratinocytes . Positive_regulation CCL27 TNF 16784723 1585636 We examined in vitro effects of antimycotics on *induced* [CCL27] , CCL2 , and CCL5 production in human keratinocytes . Positive_regulation CCL27 TNF 16784723 1585639 Antimycotics ketoconazole and terbinafine hydrochloride suppressed *induced* [CCL27] , CCL2 , and CCL5 secretion and mRNA expression in keratinocytes in parallel to the inhibition of NF-kappaB activity while fluconazole was ineffective . Positive_regulation CCL27 TNF 16784723 1585642 Anti-prostaglandin E2 ( PGE2 ) antiserum or antisense oligonucleotides against PGE2 receptor EP2 or EP3 abrogated inhibitory effects of ketoconazole and terbinafine hydrochloride on *induced* NF-kappaB activity and [CCL27] , CCL2 , and CCL5 production , indicating the involvement of endogenous PGE2 in the inhibitory effects . Positive_regulation CCL27 TNF 16784723 1585647 Carboxyheptyl imidazole also suppressed *induced* NF-kappaB activity and [CCL27] , CCL2 , and CCL5 production . Positive_regulation CCL27 TNF 16784723 1585652 These results suggest that ketoconazole and terbinafine hydrochloride may suppress *induced* NF-kappaB activity and [CCL27] , CCL2 , and CCL5 production by increasing PGE2 release from keratinocytes . Positive_regulation CCL27 TNF 20883179 2326652 ( 2S ) -2'-methoxykurarinone from Sophora flavescens suppresses [cutaneous T cell attracting chemokine/CCL27] expression *induced* by via heme oxygenase-1 in human keratinocytes . Positive_regulation CCL28 IL1B 16581045 1496454 and TNF-alpha *induce* increased expression of [CCL28] by airway epithelial cells via an NFkappaB dependent pathway . Positive_regulation CCL28 IL1B 16785557 1577136 [CCL28] was secreted by primary human cholangiocytes in vitro in *response* to LPS , , or bile acids . Positive_regulation CCL28 IL1B 20022349 2241201 In this study , we investigated whether CCL17 and [CCL28] transcription in cultured keratinocytes is *induced* by TNF-alpha , , or IFN-gamma . Positive_regulation CCL28 IL1B 20022349 2241209 It was found that CCL17 mRNA transcription is augmented by TNF-alpha only , whereas the [CCL28] mRNA level could be *increased* by TNF-alpha , , or IFN-gamma . Positive_regulation CCL28 TNF 11382928 820948 There were no changes in the levels of p65 or c-rel . *induced* a pronounced and sustained increase of a p50 homodimeric NFkappaB/DNA complex in both normal and transformed [MEC] . Positive_regulation CCL28 TNF 16433680 1516282 In this study , we showed that CCL27 and [CCL28] expression and production by a human keratinocyte cell line , HaCaT cells , were strongly *induced* by inflammatory cytokines and interleukin-1beta . Positive_regulation CCL28 TNF 16581045 1496453 IL-1beta and *induce* increased expression of [CCL28] by airway epithelial cells via an NFkappaB dependent pathway . Positive_regulation CCL28 TNF 20022349 2241199 In this study , we investigated whether CCL17 and [CCL28] transcription in cultured keratinocytes is *induced* by , IL-1beta , or IFN-gamma . Positive_regulation CCL28 TNF 20022349 2241207 It was found that CCL17 mRNA transcription is augmented by TNF-alpha only , whereas the [CCL28] mRNA level could be *increased* by , IL-1beta , or IFN-gamma . Positive_regulation CCL3 EPHB2 18802359 2021131 CysLTs induce [MIP-1alpha] and MIP-1beta production *mediated* by via binding to the CysLT(1) receptor in human monocytes/macrophages . Positive_regulation CCL3 EPHB2 21403648 2447979 Our results suggest that [CCL3] effects on OBs are *mediated* by activation and subsequent downregulation of the osteogenic transcription factor osterix . Positive_regulation CCL3 IL1B 12603824 1062506 *stimulates* [macrophage inflammatory protein-1alpha] and -1beta expression in human neuronal cells ( NT2-N ) . Positive_regulation CCL3 IL1B 12603824 1062508 Investigation of the mechanism ( s ) responsible for *induced* [MIP-1alpha] and -1beta expression demonstrated that IL-1beta activated nuclear factor kappa B (NF-kappaB) promoter directed luciferase activity in NT2-N cells . Positive_regulation CCL3 IL1B 12603824 1062510 Caffeic acid phenethyl ester , a potent and specific inhibitor of activation of NF-kappaB , not only blocked IL-1beta induced activation of the NF-kappaB promoter but also decreased *induced* [MIP-1alpha] and -1beta expression in NT2-N cells . Positive_regulation CCL3 IL1B 12603824 1062514 These data suggest that NF-kappaB is at least partially involved in the *mediated* action on [MIP-1alpha] and -1beta in NT2-N cells . Positive_regulation CCL3 IL1B 12746045 1088639 Stimulation with TNF-alpha or *increased* the MIP-1alpha and GM-CSF release from AM of normal controls and patients with pneumonia and interstitial lung disease : however , no further enhancement of [MIP-1alpha] and GM-CSF production was observed in AM from sarcoidosis patients . Positive_regulation CCL3 IL1B 16849996 1600373 Likewise , in vitro study revealed that stimulation of tubular epithelial cells by and/or H2O2 sequentially *induced* KC , [MIP-1alpha] , and MCP-1 in both protein and messenger RNA levels , which is consistent with in vivo results . Positive_regulation CCL3 IL1B 17350279 1665113 The A549 alveolar type II epithelial-like cell culture model was used to demonstrate that alveolar type II cells constitutively express CCR5 which may be upregulated by [MIP-1alpha] ( CCL3 ) whose expression was *induced* by the Th1 cytokines and IFN-gamma . Positive_regulation CCL3 IL1B 17668983 1776972 [MIP-1alpha] expression in PMNs and gingival epithelial cells was *induced* by and LPS , but neither induced MIP-1alpha expression in gingival fibroblasts or osteoblastic cells . Positive_regulation CCL3 IL1B 7485516 326877 In PBM , dexamethasone ( 10 ( -6 ) M ) reduced LPS- and *stimulated* production of [MIP-1 alpha] protein by 50 and 63 % , respectively , maximally at 24 h , whereas the inhibition of mRNA expression occurred maximally at 4 h. Similar trends were observed for AM . Positive_regulation CCL3 IL1B 7594602 325908 Both LPS ( 1 micrograms/ml ) and ( 10 ng/ml ) *induced* the expression of MIP-1 alpha mRNA and the release of [MIP-1 alpha] protein from these cells . Positive_regulation CCL3 IL1B 7594602 325910 In the presence of an anti-human IL-10 neutralizing Ab , the release of [MIP-1 alpha] *induced* by LPS and was further enhanced in monocytes but unchanged in alveolar macrophages . Positive_regulation CCL3 IL1B 7629889 316752 , tumor necrosis factor alpha , and MIP-1 alpha *had* no effect on [MIP-1 alpha] mRNA expression . Positive_regulation CCL3 IL1B 8810643 383333 We determined the effect of human recombinant IL-13 on lipopolysaccharide (LPS)- and *induced* [MIP-1 alpha] mRNA and protein expression from peripheral blood monocytes ( PBM ) and alveolar macrophages ( AM ) . Positive_regulation CCL3 IL1B 8810643 383334 LPS- and *induced* [MIP-1 alpha] mRNA expression was reduced by 43 +/- 5 % ( P < 0.01 ) and 41 +/- 4 % ( NS ) . Positive_regulation CCL3 IL1B 8862438 388662 Furthermore , induced increased IL-3 and GM-CSF mRNA expression in hematopoietic cells but *induced* decreased [macrophage inflammatory protein 1 alpha] ( MIP1 alpha ) mRNA expression as compared with SCF+IL-1 beta +IL-3 . Positive_regulation CCL3 IL1B 9570566 501606 In *response* to LPS , TNF-alpha , or , both [MIP-1 alpha] and MIP-1 beta were induced at the mRNA and protein levels in a dose- and time dependent manner . Positive_regulation CCL3 MAP2K6 14982949 1250937 Constitutively active ( MEK ) *induced* [MIP-1alpha] , and Ras dominant negative ( DN ) inhibited IC-induced ERK phosphorylation and MIP-1alpha production . Positive_regulation CCL3 TNF 10358188 618928 These results establish that T. gondii possesses the ability of driving neutrophil proinflammatory cytokine production , and they suggest that parasite induced [MIP-1 alpha] and MIP-1 beta partly *results* from autocrine stimulation through . Positive_regulation CCL3 TNF 10671210 666694 In contrast , synthesis of MCP-1 and [MIP-1alpha] was *dependent* on endogenous , but not IL-1 . Positive_regulation CCL3 TNF 12746045 1088638 Stimulation with or IL-1beta *increased* the MIP-1alpha and GM-CSF release from AM of normal controls and patients with pneumonia and interstitial lung disease : however , no further enhancement of [MIP-1alpha] and GM-CSF production was observed in AM from sarcoidosis patients . Positive_regulation CCL3 TNF 15831559 1425404 In summary , we have demonstrated that neutrophil migration observed in this model of immune inflammation is mediated by [MIP-1alpha] [ CCL3 ] , which via CCR1 , *induces* the sequential release of and LTB ( 4 ) . Positive_regulation CCL3 TNF 17372028 1713758 AdProTDeltaNLS treatment abolished the up-regulation of the [MIP-1alpha] promoter activity *induced* by in synovial fibroblasts . Positive_regulation CCL3 TNF 17698589 1788662 [CCL3] *induces* a rapid secretion by innate inflammatory mononuclear phagocytic cells ( MPCs ) , which further promotes the production of radical oxygen intermediates ( ROIs ) by both MPCs and neutrophils . Positive_regulation CCL3 TNF 18802121 1965050 *stimulated* YKL-40 synthesis in alveolar macrophages from smokers with COPD , and exposure of these cells to YKL-40 promoted the release of IL-8 , MCP-1 , [MIP-1alpha] , and metalloproteinase-9 . Positive_regulation CCL3 TNF 20463923 2257861 Similarly *caused* an increase in the serum levels of IL-6 , [MIP-1alpha] and MIP-1beta : this increase in cytokine/chemokine levels was inhibited in mice where PLD1 had been silenced . Positive_regulation CCL3 TNF 21997704 2599358 Inhibition of *reduced* the spontaneous release of CXCL-8 and [CCL-3] . Positive_regulation CCL3 TNF 7500047 336179 IL-8 production induced by TNF-alpha and GM-CSF was synergistically enhanced in the presence of MSU or CPPD , whereas [MIP-1 alpha] secretion *induced* by was completely inhibited in the presence of either MSU or CPPD . Positive_regulation CCL3 TNF 7539030 306934 Furthermore , our results indicate that [MIP-1 alpha] expression is *mediated* by alveolar macrophage derived , identifying an important cytokine pathway in the initiation of pulmonary fibrosis . Positive_regulation CCL3 TNF 9570566 501605 In *response* to LPS , , or IL-1 beta , both [MIP-1 alpha] and MIP-1 beta were induced at the mRNA and protein levels in a dose- and time dependent manner . Positive_regulation CCL3 TNF 9787141 541646 *induced* [MIP-1alpha] receptor upregulation in a time- and concentration dependent manner . Positive_regulation CCL3 TNF 9822259 548711 induced MCP-1 , RANTES and MIP-1beta mRNA expression , and lipopolysaccharide (LPS) *induced* MCP-1 , [MIP-1alpha] and MIP-1beta mRNA expression in astrocytes . Positive_regulation CCL4 EPHB2 18802359 2021132 CysLTs induce MIP-1alpha and [MIP-1beta] production *mediated* by via binding to the CysLT(1) receptor in human monocytes/macrophages . Positive_regulation CCL4 IL1B 12603824 1062509 Investigation of the mechanism ( s ) responsible for *induced* [MIP-1alpha and -1beta] expression demonstrated that IL-1beta activated nuclear factor kappa B (NF-kappaB) promoter directed luciferase activity in NT2-N cells . Positive_regulation CCL4 IL1B 12603824 1062511 Caffeic acid phenethyl ester , a potent and specific inhibitor of activation of NF-kappaB , not only blocked IL-1beta induced activation of the NF-kappaB promoter but also decreased *induced* [MIP-1alpha and -1beta] expression in NT2-N cells . Positive_regulation CCL4 IL1B 12603824 1062517 These data suggest that NF-kappaB is at least partially involved in the *mediated* action on [MIP-1alpha and -1beta] in NT2-N cells . Positive_regulation CCL4 IL1B 14746807 1182112 significantly *enhanced* [MIP-1beta] expression in these cells at both the mRNA and protein levels . Positive_regulation CCL4 IL1B 14746807 1182113 Investigation of the mechanism involved in [MIP-1beta] *induction* by showed that IL-1beta activated the nuclear factor kappa B (NF-kappaB) promoter in Huh7 cells . Positive_regulation CCL4 IL1B 14746807 1182116 In addition , caffeic acid phenethyl ester ( CAPE ) , a specific inhibitor of the activation of NF-kappaB , not only abolished IL-1beta mediated NF-kappaB promoter activation , but also blocked *induced* [MIP-1beta] expression . Positive_regulation CCL4 IL1B 14746807 1182119 These observations suggest that *mediated* up-regulation of [MIP-1beta] production in the hepatic cells may contribute a critical mechanism for continuous recruitment of inflammatory cell to liver and maintenance of inflammation . Positive_regulation CCL4 IL1B 15450530 1300742 highly *stimulated* *NO , IL-8 , IL-6 , [MIP-1beta] and PGE ( 2 ) synthesis but decreased AGG and TGF-beta1 production . Positive_regulation CCL4 IL1B 15450530 1300745 At 1-10ng/ml , OSM significantly decreased *stimulated* IL-8 , [MIP-1beta] , PGE ( 2 ) and *NO production but amplified IL-1beta stimulating effect on IL-6 production . Positive_regulation CCL4 IL1B 18789903 1976125 Helioxanthin inhibits *induced* [MIP-1 beta] production by reduction of c-jun expression and binding of the c-jun/CREB1 complex to the AP-1/CRE site of the MIP-1 beta promoter in Huh7 cells . Positive_regulation CCL4 IL1B 18789903 1976127 However , molecular mechanism of *induced* [MIP-1beta] expression in hepatic cells is obscure . Positive_regulation CCL4 IL1B 18789903 1976128 Here , we demonstrated that HE-145 inhibited *induced* [MIP-1beta] expression in a dose dependent manner in Huh7 cells . Positive_regulation CCL4 IL1B 18789903 1976129 To understand the mode of action of HE-145 , we first examined how *induced* [MIP-1beta] expression at the molecular level . Positive_regulation CCL4 IL1B 18789903 1976130 Using selective inhibitors , we found that JNK and p38 pathways participated in *induced* [MIP-1beta] expression . Positive_regulation CCL4 IL1B 18789903 1976133 The inhibitory effect of HE-145 on *induced* [MIP-1beta] promoter activity was completely reversed by overexpressing c-jun. Electrophoretic mobility shift assay ( EMSA ) and chromatin immunoprecipitation ( ChIP ) assay consistently revealed that HE-145 reduced c-jun binding to the AP-1/CRE site in vitro and in vivo . Positive_regulation CCL4 IL1B 18789903 1976134 Our results established a major role for c-jun in *induced* [MIP-1beta] expression in hepatic cells . Positive_regulation CCL4 IL1B 18789903 1976136 The reduction in IL-1beta induced c-jun expression and subsequent binding of the c-jun/CREB1 complex to AP-1/CRE site mainly contributed to the inhibitory action of HE-145 on *induced* [MIP-1beta] production . Positive_regulation CCL4 IL1B 9570566 501608 In *response* to LPS , TNF-alpha , or , both MIP-1 alpha and [MIP-1 beta] were induced at the mRNA and protein levels in a dose- and time dependent manner . Positive_regulation CCL4 ITGB2 11069084 747700 Cross linking of *induces* secretion of macrophage inflammatory protein (MIP)-lalpha and [MIP-1beta] with consequent directed migration of activated lymphocytes . Positive_regulation CCL4 TGM2 19099152 2004035 *increased* in both groups ( EtOH + [CCl4] : 66.4 +/- 8 % , P < 0.01 ; Positive_regulation CCL4 TNF 10358188 618929 These results establish that T. gondii possesses the ability of driving neutrophil proinflammatory cytokine production , and they suggest that parasite induced MIP-1 alpha and [MIP-1 beta] partly *results* from autocrine stimulation through . Positive_regulation CCL4 TNF 10496934 647237 Divergent *roles* of and platelet activating factor in endotoxin induced release of monocyte chemoattractant protein 1 and [macrophage inflammatory protein 1beta] in chimpanzees . Positive_regulation CCL4 TNF 20463923 2257862 Similarly *caused* an increase in the serum levels of IL-6 , MIP-1alpha and [MIP-1beta] : this increase in cytokine/chemokine levels was inhibited in mice where PLD1 had been silenced . Positive_regulation CCL4 TNF 9570566 501607 In *response* to LPS , , or IL-1 beta , both MIP-1 alpha and [MIP-1 beta] were induced at the mRNA and protein levels in a dose- and time dependent manner . Positive_regulation CCL4 TNF 9822259 548713 *induced* MCP-1 , RANTES and [MIP-1beta] mRNA expression , and lipopolysaccharide (LPS) induced MCP-1 , MIP-1alpha and MIP-1beta mRNA expression in astrocytes . Positive_regulation CCL4 TNF 9822259 548722 IL-10 , but not TGF-beta1 , inhibited [MIP-1beta] mRNA expression *induced* by . Positive_regulation CCL4 TNFSF10 19120450 2019360 In this article , it is shown that *induces* CXCL2 , [CCL4] and CCL20 secretion in a nuclear factor kappa B-dependent manner . Positive_regulation CCL4L2 IL1B 14746807 1182108 *induces* [macrophage inflammatory protein-1beta] expression in human hepatocytes . Positive_regulation CCL4L2 IL1B 18789903 1976126 An elevated level of [macrophage inflammatory protein-1beta] ( MIP-1beta ) *induced* by has been correlated with chronic hepatic inflammatory disease . Positive_regulation CCL5 EPHB2 19479862 2097665 The MAPKs p38 , JNK , and were necessary for IL-6 production , but phosphatidylinositol 3-kinase ( PI 3-kinase ) was *required* for selective [CCL5] induction . Positive_regulation CCL5 IL1B 11330934 808294 ( 3-300 pg/ml ) also *enhanced* the production of [Rantes/CCL5] in gingival fibroblasts . Positive_regulation CCL5 IL1B 11330934 808295 The amount of [Rantes/CCL5] *induced* by ( 300 pg/ml ) , however , was less than that induced by TNFalpha ( 10 ng/ml ) . Positive_regulation CCL5 IL1B 11673556 872879 On the other hand , CCL2 , [CCL5] , and CXCL12 were expressed on RA FLS , and their production was *regulated* by TNF-alpha , , and TGF-beta1 . Positive_regulation CCL5 IL1B 15749911 1379786 We now show , using real-time PCR , that in astrocytes *induces* the expression of IFN-beta , IRF7 , CXCL10/IFN-gamma-inducible protein-10 , and [CCL5/RANTES] . Positive_regulation CCL5 IL1B 16424382 1547536 After 1 h pretreatment , combined treatment significantly inhibited rhinovirus 16 , 1B , and *induced* [CCL5] and CXCL8 protein and mRNA production in BEAS-2B cells compared with fluticasone alone . Positive_regulation CCL5 IL1B 17126080 1677626 We investigated *induced* CXCL8 and [CCL5] secretion from primary normal human bronchial and small airway epithelial cells , and the alveolar cell line A549 . Positive_regulation CCL5 IL1B 17126080 1677630 The IL-1 related cytokine IL-18 did not drive or modulate *induced* CXCL8 or [CCL5] secretion . Positive_regulation CCL5 IL1B 20032224 2205114 GTE ( 2.5-40 microg/ml ) inhibited *induced* MCP-1/CCL2 ( 10 ng/ml ) , [RANTES/CCL5] , GROalpha/CXCL1 and IL-8/CXCL8 production in human RA synovial fibroblasts ( P < 0.05 ) . Positive_regulation CCL5 S100B 21209080 2391851 The *dependent* activation of diaphanous-1/Rac1/JNK/AP-1 , Ras/Rac1/NF-?B and Src/Ras/PI3K/RhoA/diaphanous-1 results in the up-regulation of expression of the chemokines , CCL3 , [CCL5] , and CXCL12 , whose release and activity are required for S100B to stimulate microglia migration . Positive_regulation CCL5 TLR7 24711619 2935581 SARM was not required for *induced* activation of MAPKs or of transcription factors implicated in [CCL5] induction , namely NF-?B and IFN regulatory factors , nor for Ccl5 mRNA stability or splicing . Positive_regulation CCL5 TNF 11330934 808293 The expression of [Rantes/CCL5-mRNA] and protein production , *induced* by , was evident at 6 h and thereafter increased continuously during the study period ( 24 h ) . Positive_regulation CCL5 TNF 11673556 872878 On the other hand , CCL2 , [CCL5] , and CXCL12 were expressed on RA FLS , and their production was *regulated* by , IL-1beta , and TGF-beta1 . Positive_regulation CCL5 TNF 16784723 1585634 Suppressive effects of antimycotics on *induced* CCL27 , CCL2 , and [CCL5] production in human keratinocytes . Positive_regulation CCL5 TNF 16784723 1585637 We examined in vitro effects of antimycotics on *induced* CCL27 , CCL2 , and [CCL5] production in human keratinocytes . Positive_regulation CCL5 TNF 16784723 1585640 Antimycotics ketoconazole and terbinafine hydrochloride suppressed *induced* CCL27 , CCL2 , and [CCL5] secretion and mRNA expression in keratinocytes in parallel to the inhibition of NF-kappaB activity while fluconazole was ineffective . Positive_regulation CCL5 TNF 16784723 1585643 Anti-prostaglandin E2 ( PGE2 ) antiserum or antisense oligonucleotides against PGE2 receptor EP2 or EP3 abrogated inhibitory effects of ketoconazole and terbinafine hydrochloride on *induced* NF-kappaB activity and CCL27 , CCL2 , and [CCL5] production , indicating the involvement of endogenous PGE2 in the inhibitory effects . Positive_regulation CCL5 TNF 16784723 1585648 Carboxyheptyl imidazole also suppressed *induced* NF-kappaB activity and CCL27 , CCL2 , and [CCL5] production . Positive_regulation CCL5 TNF 16784723 1585653 These results suggest that ketoconazole and terbinafine hydrochloride may suppress *induced* NF-kappaB activity and CCL27 , CCL2 , and [CCL5] production by increasing PGE2 release from keratinocytes . Positive_regulation CCL5 TNF 18941244 1978177 IL-17 strongly repressed *stimulated* expression of CXCL10 , CXCL11 , and [CCL5] , but synergized with TNF-alpha for induction of CXCL8 , CXCL1 , and CCL20 mRNAs . Positive_regulation CCL5 TNF 19225413 2039889 strongly *increased* the production of CCL2 , [CCL5] , and CXCL8 ; Positive_regulation CCL5 TNF 20523058 2271274 Cooperative *activation* of [CCL5] expression by TLR3 and or interferon-gamma through nuclear factor-kappaB or STAT-1 in airway epithelial cells . Positive_regulation CCL5 TNF 20861350 2331704 Our results suggest that LPA inhibits IFN-?- and *induced* [CCL5/RANTES] production in BEAS-2B cells by blocking the binding of IRF-1 to the CCL5/RANTES promoter . Positive_regulation CCL5 TNF 22452977 2588629 Evaluation of roflumilast ( 1-10 µM ) showed no significant inhibition alone on TGFß1 induced ET-1 and CTGF mRNA transcripts , ET-1 and FN protein production , alpha smooth muscle expression , or *induced* secretion of CXCL10 , [CCL5] and GM-CSF . Positive_regulation CCL5 TNF 23524263 2772274 LL-37 inhibited the increase of CXCL10 and [CCL5] *induced* by and/or IFN-? but enhanced that of CXCL8 . Positive_regulation CCL5 TNF 24523572 2914624 Stimulation of HPFB with IL-1ß and *resulted* in a time- ( up to 96 h ) and dose dependent increase in [CCL5] expression and release . Positive_regulation CCL7 EPHB2 12854631 1110225 We conclude that p38 MAPK , JNK kinase , and NF-kappaB are *involved* in the IL-1beta induced eotaxin , MCP-1 , and [MCP-3] expression and release in HASMC . Positive_regulation CCL7 IL1B 12854631 1110226 We conclude that p38 MAPK , JNK kinase , ERK and NF-kappaB are involved in the *induced* eotaxin , MCP-1 , and [MCP-3] expression and release in HASMC . Positive_regulation CCL7 IL1B 17077666 1642383 In contrast , Dex treatment inhibited the *induced* production of GM-CSF , IL-6 , IL-8 , [MCP-3] , and RANTES , but not MCP-1 . Positive_regulation CCL7 IL1B 19577550 2117561 This study aims to test the ability of and TNF-alpha to *stimulate* CCL2 and [CCL7] protein production in rat astrocyte cultures , and to elucidate signaling pathways involved in the cytokine stimulated chemokine upregulation . Positive_regulation CCL7 TNF 16750176 1570660 In MC3T3-E1 cells , apigenin dose-dependently ( from 5 to 20 microM ) inhibits *induced* production of the osteoclastogenic cytokines , IL-6 ( interleukin-6 ) , RANTES ( regulated upon activation , normal T cell expressed and -secreted ) , monocyte chemoattractant protein-1 ( MCP-1 ) and [MCP-3] . Positive_regulation CCL7 TNF 19577550 2117560 This study aims to test the ability of IL-1beta and to *stimulate* CCL2 and [CCL7] protein production in rat astrocyte cultures , and to elucidate signaling pathways involved in the cytokine stimulated chemokine upregulation . Positive_regulation CCL7 TNF 21279498 2414574 Here , we demonstrate that MCP-3/CCL7 is a significant chemokine produced by astrocytes , that basal monocyte migration may be facilitated by astrocyte derived CCL7 , that production of [CCL7] is rapidly *increased* by and thus likely plays a critical role in initiating neuroinvasion by SIV/HIV . Positive_regulation CCL7 TNF 24719782 2932011 *induced* CCL2 , [CCL7] , and CXCL1 in preadipocytes but had no response in adipocytes . Positive_regulation CCL8 IL1B 12391243 1007324 Moreover , OSM synergistically blocked *induced* CXC [chemokine ligand 8] secretion in combination with the IL-6/sIL-6R complex . Positive_regulation CCL8 IL1B 18565769 1984266 In the *presence* of , FGF-18 increased expression of ADAMTS-4 , aggrecan , BMP-2 , COL2A1 , CCL3 , CCL4 , CCL20 , CXCL1 , CXCL3 , CXCL6 , IL-1beta , IL-6 , and IL-8 and decreased ADAMTS-5 , MMP-13 , CCL2 , and [CCL8] . Positive_regulation CCL8 IL1B 19224633 2044673 [MCP-2/CC] chemokine ligand 8 (CCL8) was *induced* at only suboptimal levels in fibroblasts and endothelial cells by or IFN-gamma , unless these cytokines were combined . Positive_regulation CCL8 IL1B 8189067 257015 In connective tissue cells , was the best inducer of MCP-1 , but IFN-gamma was a superior *inducer* of [MCP-2] . Positive_regulation CCL8 IL1B 9500525 490795 Synergistic *induction* of [MCP-1 and -2] by and interferons in fibroblasts and epithelial cells . Positive_regulation CCL8 TNF 15644410 1394923 TRAIL pretreatment variably down modulated the mRNA steady-state levels of several TNF-alpha induced chemokines , and , in particular , it abrogated the *mediated* up-regulation of [CCL8] and CXCL10 . Positive_regulation CCNA1 TNF 18787932 2012242 Post-translational modification of [cyclin A1] is associated with staurosporine and *induced* apoptosis in leukemic cells . Positive_regulation CCNA1 TNF 18787932 2012244 Induction of apoptosis in U-937 cells by staurosporine or *resulted* in an increase in [cyclin A1] protein expression , which correlated well with cyclin A1 protein modification and the activation of caspase-3 . Positive_regulation CCNA2 TNF 15349890 1292348 In addition , the expression of hematopoietic cytokines and [cyclin A2] , repressed by OSM and matrigel , is *induced* by in the fetal hepatic cultures coincident with cell division . Positive_regulation CCNB1 AGR2 11211931 785654 arrest results , which is characterised by abnormal metaphase morphology , *increased* levels of [cyclin B1] and enhanced cdc2 kinase activity . Positive_regulation CCNB1 EPHB2 20664969 2298217 Immunoblot analysis demonstrated that oridonin treatment increased expression levels of p-JNK , p-p38 , p-p53 and p21 , elevated the level of [cyclin B1/p-Cdc2] ( Tyr15 ) complex , and *inhibited* the expression of . Positive_regulation CCNB1 FAS 20937773 2347746 [Cdk1/cyclin B1] controls *mediated* apoptosis by regulating caspase-8 activity . Positive_regulation CCNB1 IL1B 23971193 2832828 Cyclin A and [cyclin B1] were *increased* by ( 1 ng/ml ) , but the level of cyclin D1 and total DNA content was unaffected . Positive_regulation CCNB1 TP63 18331776 1904687 The results of western blot analysis further showed that increases of and p73 protein translation or stability might be *contribute* to the regulation of GADD45beta , 14-3-3sigma , [cyclin B1] and PIG3 . Positive_regulation CCNC ANGPT1 12890486 1117460 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation CCNC ANGPT1 16638932 1589723 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation CCNC CD14 16574244 1582629 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation CCNC CHI3L1 18802121 1965022 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation CCNC EDN2 7693285 231247 *induced* contraction and [mediator] release in human bronchus . Positive_regulation CCNC EDN2 9124581 424050 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation CCNC EPHB2 20138154 2227058 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation CCNC EPHB2 23684917 2796482 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation CCNC ID1 11278321 798180 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation CCNC IL1B 7859071 287108 The results showed that *increased* NKA-li selectively in the median eminence ( ME ) and [arcuate nucleus (ARC)] of castrated rats only . Positive_regulation CCNC IL1B 9810029 545617 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation CCNC ITGB2 9152024 430907 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation CCNC LBP 16574244 1582630 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation CCNC TLR7 19631980 2131763 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation CCNC TNF 11159885 781419 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation CCNC TNF 12524657 1047949 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation CCNC TNF 14550746 1152725 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation CCNC TNF 14982858 1214527 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation CCNC TNF 17307735 1719086 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation CCNC TNF 17988550 1821505 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation CCNC TNF 18675993 2011423 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation CCNC TNF 21904602 2478308 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation CCNC TNF 23684917 2796481 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation CCNC TNF 2788206 116803 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation CCNC TNF 3292408 94746 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation CCNC TNF 8453746 215219 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation CCNC TNF 8679220 372472 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation CCND1 ABCC6 15936818 1452011 Valproate induced a clear G1 phase arrest and up-regulated [cyclin D1] expression in the *presence* of and etoposide . Positive_regulation CCND1 ABCC6 17510080 1778275 is *involved* in transcriptional regulation of the [cyclin D1] gene in human cancer cells . Positive_regulation CCND1 ABCC6 17510080 1778278 In this study , we identified a novel *role* for in the regulation of [cyclin D1] expression in the absence of AR stimulation in human cancer cells . Positive_regulation CCND1 ABL1 12101248 962568 A reduction in endogenous cyclin D1 levels that coincided with NF-kappaB1 transgene reversal of enhanced nfkb1 ( -/- ) pre-B-cell transformation , coupled with NF-kappaB1 inhibition of *induced* kappaB dependent murine [cyclin D1] transcription , lends support to a model in which v-Abl induced cyclin D1 transcription in transformed pre-B cells is controlled by Rel/NF-kappaB dimers with different activities . Positive_regulation CCND1 AGAP2 20075866 2212454 Depletion of in HC11 epithelial cells *diminished* PRL induced STAT5 activation and [cyclin D1] expression , resulting in profoundly impaired cell proliferation in vitro . Positive_regulation CCND1 AGR2 20525379 2295375 Conversely , [cyclin D1] was *induced* with recombinant . Positive_regulation CCND1 AHR 24380854 2906716 Collectively , our findings have revealed a new regulatory mechanism by which IGF-2 induction of *promotes* the expression of [CCND1] and the proliferation of MCF-7 cells . Positive_regulation CCND1 AKT1 10419529 631935 Activated PI 3-kinase *induces* [cyclin D(1)] transcription and E2F activity , at least in part mediated by the serine/threonine kinase , and to a lesser extent the Rho family GTPase Rac . Positive_regulation CCND1 AKT1 12589056 1059882 PI3K dependent induction of [cyclin D1] was *blocked* by inhibitors of or beta-catenin signaling . Positive_regulation CCND1 AKT1 14500737 1144244 Pentoxifylline *inhibits* platelet derived growth factor stimulated [cyclin D1] expression in mesangial cells by blocking membrane translocation . Positive_regulation CCND1 AKT1 15001399 1217062 [Cyclin D1] expression and cell-cycle progression *followed* the metal induced phosphorylation . Positive_regulation CCND1 AKT1 15634685 1380925 [Cyclin D1] and c-myc internal ribosome entry site ( IRES ) -dependent translation is *regulated* by activity and enhanced by rapamycin through a p38 MAPK- and ERK dependent pathway . Positive_regulation CCND1 AKT1 16387740 1533421 Furthermore , inhibition of by overexpression of Deltap85 or DN-Akt *blocked* arsenite induced IKK phosphorylation , IkappaBalpha degradation and [cyclin D1] expression , indicating that IKK/NFkappaB is the downstream transducer of arsenite triggered PI-3K/Akt cascade . Positive_regulation CCND1 AKT1 17473212 1738316 Overexpression of kinase dead mutant or phosphorylation-defective CREB *inhibited* [cyclin D1] transcriptional activity . Positive_regulation CCND1 AKT1 17473212 1738322 The current study shows that Nexrutine mediated targeting of induced *activation* of [cyclin D1] prevents the progression of prostate cancer . Positive_regulation CCND1 AKT1 18197291 1857168 Our results demonstrate that *mediated* [cyclin D1] expression is at least one key event implicated in the arsenite human skin carcinogenic effect . Positive_regulation CCND1 AKT1 18339899 1904989 Moreover , inhibition *down-regulated* [cyclin D1] by promoting its proteasome dependent degradation driven by GSK-3 . Positive_regulation CCND1 AKT1 19255500 2045200 LA-induced increases in the cell cycle regulatory proteins , [cyclin D1] , cyclin E , cyclin dependent kinase (CDK) 2 , and CDK 4 , were *blocked* by U73122 , staurosporine , LY294002 , inhibitor , PD98059 , and metformin ( gluconeogenesis inhibitor ) . Positive_regulation CCND1 AKT1 19935697 2210088 The expression of [cyclin D1] *required* both EGFR mediated ERK and activation . Positive_regulation CCND1 AKT1 20018914 2217620 Moreover , MV-mediated activation *led* to modulation of the beta-catenin pathway and increased expression of [cyclin D1] and c-myc in BMSCs . Positive_regulation CCND1 AKT1 20385773 2262010 Elevating the levels of active *restores* the expression of [cyclin D1] and proliferation of Jak2-deficient mammary epithelial cells , which provides evidence that Akt1 acts downstream of Jak/Stat signaling . Positive_regulation CCND1 AKT1 20539939 2271686 The inhibitor 1701-1 significantly *diminished* the expression of phospho-Akt , phospho-ERK1/2 , and [cyclin D1] stimulated by apelin-13 . Positive_regulation CCND1 AKT1 20562919 2308870 A positive feedback loop was responsible for the [cyclin D1] overexpression in which constitutively active was *involved* . Positive_regulation CCND1 AKT1 20724534 2306862 These findings demonstrate for the first time that dependent [cyclin D1] *activation* plays an essential role in HDL induced EPC proliferation , migration and angiogenesis . Positive_regulation CCND1 AKT1 20836878 2325623 Furthermore , this effect was concomitant with induction of phosphorylation of ( ser473 ) and its downstream target phospho ( ser9 ) GSK3ß , and *increased* [Cyclin D1] and C-Myc protein levels . Positive_regulation CCND1 AKT1 21777670 2484518 The major effect of Akt3 on the proliferation of DTC was associated with an Akt3 mediated regulation of both , cyclin D1 and cyclin D3 , whereas *regulated* the expression of [cyclin D1] only . Positive_regulation CCND1 AKT1 22393466 2521069 Taken together , these findings suggest that activation of NF-?B by Pdcd4 knockdown through *contributes* to the elevated expression of [cyclin D1] , thus providing new insights into how loss of Pdcd4 expression promotes tumor development . Positive_regulation CCND1 AKT1 22579115 2609537 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated [Cyclin D1] and Cyclin B1 proteins as well as *activation* of and Raf/MEK/ERK , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation CCND1 AKT1 23237355 2711152 Essential oil activated the caspase dependent apoptotic pathway , *induced* a rapid and transient activation of and Erk1/2 , and suppressed levels of [cyclin D1 cdk4] expression in cultured pancreatic cancer cells . Positive_regulation CCND1 AKT1 23300886 2712458 Pharmacological inhibition of JAK/STAT3 , or MEK/ERK signaling by AG490 , Wortmannin or U0126 , respectively , *reduced* leptin induced [cyclin D1] expression and NP cell proliferation . Positive_regulation CCND1 AKT1 24737397 2943095 Mechanistically , aberrant PRL-3 expression promoted cell cycle progression and enhanced the antiapoptotic machinery of AML cells to drug cytotoxicity through downregulation of p21 and upregulation of [Cyclin D1] and CDK2 and *activation* of STAT5 and . Positive_regulation CCND1 AKT2 10419529 631936 Activated PI 3-kinase *induces* [cyclin D(1)] transcription and E2F activity , at least in part mediated by the serine/threonine kinase , and to a lesser extent the Rho family GTPase Rac . Positive_regulation CCND1 AKT2 12589056 1059883 PI3K dependent induction of [cyclin D1] was *blocked* by inhibitors of or beta-catenin signaling . Positive_regulation CCND1 AKT2 14500737 1144245 Pentoxifylline *inhibits* platelet derived growth factor stimulated [cyclin D1] expression in mesangial cells by blocking membrane translocation . Positive_regulation CCND1 AKT2 15001399 1217063 [Cyclin D1] expression and cell-cycle progression *followed* the metal induced phosphorylation . Positive_regulation CCND1 AKT2 15634685 1380926 [Cyclin D1] and c-myc internal ribosome entry site ( IRES ) -dependent translation is *regulated* by activity and enhanced by rapamycin through a p38 MAPK- and ERK dependent pathway . Positive_regulation CCND1 AKT2 16387740 1533422 Furthermore , inhibition of by overexpression of Deltap85 or DN-Akt *blocked* arsenite induced IKK phosphorylation , IkappaBalpha degradation and [cyclin D1] expression , indicating that IKK/NFkappaB is the downstream transducer of arsenite triggered PI-3K/Akt cascade . Positive_regulation CCND1 AKT2 17473212 1738317 Overexpression of kinase dead mutant or phosphorylation-defective CREB *inhibited* [cyclin D1] transcriptional activity . Positive_regulation CCND1 AKT2 17473212 1738323 The current study shows that Nexrutine mediated targeting of *induced* activation of [cyclin D1] prevents the progression of prostate cancer . Positive_regulation CCND1 AKT2 18197291 1857169 Our results demonstrate that *mediated* [cyclin D1] expression is at least one key event implicated in the arsenite human skin carcinogenic effect . Positive_regulation CCND1 AKT2 18339899 1904990 Moreover , inhibition *down-regulated* [cyclin D1] by promoting its proteasome dependent degradation driven by GSK-3 . Positive_regulation CCND1 AKT2 19255500 2045201 LA-induced increases in the cell cycle regulatory proteins , [cyclin D1] , cyclin E , cyclin dependent kinase (CDK) 2 , and CDK 4 , were *blocked* by U73122 , staurosporine , LY294002 , inhibitor , PD98059 , and metformin ( gluconeogenesis inhibitor ) . Positive_regulation CCND1 AKT2 19935697 2210089 The expression of [cyclin D1] *required* both EGFR mediated ERK and activation . Positive_regulation CCND1 AKT2 20018914 2217621 Moreover , MV-mediated activation *led* to modulation of the beta-catenin pathway and increased expression of [cyclin D1] and c-myc in BMSCs . Positive_regulation CCND1 AKT2 20539939 2271687 The inhibitor 1701-1 significantly *diminished* the expression of phospho-Akt , phospho-ERK1/2 , and [cyclin D1] stimulated by apelin-13 . Positive_regulation CCND1 AKT2 20562919 2308871 A positive feedback loop was responsible for the [cyclin D1] overexpression in which constitutively active was *involved* . Positive_regulation CCND1 AKT2 20724534 2306863 These findings demonstrate for the first time that *dependent* [cyclin D1] activation plays an essential role in HDL induced EPC proliferation , migration and angiogenesis . Positive_regulation CCND1 AKT2 20836878 2325624 Furthermore , this effect was concomitant with induction of phosphorylation of ( ser473 ) and its downstream target phospho ( ser9 ) GSK3ß , and *increased* [Cyclin D1] and C-Myc protein levels . Positive_regulation CCND1 AKT2 22393466 2521070 Taken together , these findings suggest that activation of NF-?B by Pdcd4 knockdown through *contributes* to the elevated expression of [cyclin D1] , thus providing new insights into how loss of Pdcd4 expression promotes tumor development . Positive_regulation CCND1 AKT2 22579115 2609538 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated [Cyclin D1] and Cyclin B1 proteins as well as *activation* of and Raf/MEK/ERK , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation CCND1 AKT2 23237355 2711153 Essential oil activated the caspase dependent apoptotic pathway , *induced* a rapid and transient activation of and Erk1/2 , and suppressed levels of [cyclin D1 cdk4] expression in cultured pancreatic cancer cells . Positive_regulation CCND1 AKT2 23300886 2712459 Pharmacological inhibition of JAK/STAT3 , or MEK/ERK signaling by AG490 , Wortmannin or U0126 , respectively , *reduced* leptin induced [cyclin D1] expression and NP cell proliferation . Positive_regulation CCND1 AKT2 24737397 2943096 Mechanistically , aberrant PRL-3 expression promoted cell cycle progression and enhanced the antiapoptotic machinery of AML cells to drug cytotoxicity through downregulation of p21 and upregulation of [Cyclin D1] and CDK2 and *activation* of STAT5 and . Positive_regulation CCND1 AKT3 10419529 631937 Activated PI 3-kinase *induces* [cyclin D(1)] transcription and E2F activity , at least in part mediated by the serine/threonine kinase , and to a lesser extent the Rho family GTPase Rac . Positive_regulation CCND1 AKT3 12589056 1059884 PI3K dependent induction of [cyclin D1] was *blocked* by inhibitors of or beta-catenin signaling . Positive_regulation CCND1 AKT3 14500737 1144246 Pentoxifylline *inhibits* platelet derived growth factor stimulated [cyclin D1] expression in mesangial cells by blocking membrane translocation . Positive_regulation CCND1 AKT3 15001399 1217064 [Cyclin D1] expression and cell-cycle progression *followed* the metal induced phosphorylation . Positive_regulation CCND1 AKT3 15634685 1380927 [Cyclin D1] and c-myc internal ribosome entry site ( IRES ) -dependent translation is *regulated* by activity and enhanced by rapamycin through a p38 MAPK- and ERK dependent pathway . Positive_regulation CCND1 AKT3 16387740 1533423 Furthermore , inhibition of by overexpression of Deltap85 or DN-Akt *blocked* arsenite induced IKK phosphorylation , IkappaBalpha degradation and [cyclin D1] expression , indicating that IKK/NFkappaB is the downstream transducer of arsenite triggered PI-3K/Akt cascade . Positive_regulation CCND1 AKT3 17473212 1738318 Overexpression of kinase dead mutant or phosphorylation-defective CREB *inhibited* [cyclin D1] transcriptional activity . Positive_regulation CCND1 AKT3 17473212 1738324 The current study shows that Nexrutine mediated targeting of induced *activation* of [cyclin D1] prevents the progression of prostate cancer . Positive_regulation CCND1 AKT3 18197291 1857170 Our results demonstrate that *mediated* [cyclin D1] expression is at least one key event implicated in the arsenite human skin carcinogenic effect . Positive_regulation CCND1 AKT3 18339899 1904991 Moreover , inhibition *down-regulated* [cyclin D1] by promoting its proteasome dependent degradation driven by GSK-3 . Positive_regulation CCND1 AKT3 19255500 2045202 LA-induced increases in the cell cycle regulatory proteins , [cyclin D1] , cyclin E , cyclin dependent kinase (CDK) 2 , and CDK 4 , were *blocked* by U73122 , staurosporine , LY294002 , inhibitor , PD98059 , and metformin ( gluconeogenesis inhibitor ) . Positive_regulation CCND1 AKT3 19935697 2210090 The expression of [cyclin D1] *required* both EGFR mediated ERK and activation . Positive_regulation CCND1 AKT3 20018914 2217622 Moreover , MV-mediated activation *led* to modulation of the beta-catenin pathway and increased expression of [cyclin D1] and c-myc in BMSCs . Positive_regulation CCND1 AKT3 20539939 2271688 The inhibitor 1701-1 significantly *diminished* the expression of phospho-Akt , phospho-ERK1/2 , and [cyclin D1] stimulated by apelin-13 . Positive_regulation CCND1 AKT3 20562919 2308872 A positive feedback loop was responsible for the [cyclin D1] overexpression in which constitutively active was *involved* . Positive_regulation CCND1 AKT3 20724534 2306864 These findings demonstrate for the first time that dependent [cyclin D1] *activation* plays an essential role in HDL induced EPC proliferation , migration and angiogenesis . Positive_regulation CCND1 AKT3 20836878 2325625 Furthermore , this effect was concomitant with induction of phosphorylation of ( ser473 ) and its downstream target phospho ( ser9 ) GSK3ß , and *increased* [Cyclin D1] and C-Myc protein levels . Positive_regulation CCND1 AKT3 21777670 2484519 The major effect of Akt3 on the proliferation of DTC was associated with an *mediated* regulation of both , [cyclin D1] and cyclin D3 , whereas Akt1 regulated the expression of cyclin D1 only . Positive_regulation CCND1 AKT3 22393466 2521071 Taken together , these findings suggest that activation of NF-?B by Pdcd4 knockdown through *contributes* to the elevated expression of [cyclin D1] , thus providing new insights into how loss of Pdcd4 expression promotes tumor development . Positive_regulation CCND1 AKT3 22579115 2609539 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated [Cyclin D1] and Cyclin B1 proteins as well as *activation* of and Raf/MEK/ERK , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation CCND1 AKT3 23237355 2711154 Essential oil activated the caspase dependent apoptotic pathway , *induced* a rapid and transient activation of and Erk1/2 , and suppressed levels of [cyclin D1 cdk4] expression in cultured pancreatic cancer cells . Positive_regulation CCND1 AKT3 23300886 2712460 Pharmacological inhibition of JAK/STAT3 , or MEK/ERK signaling by AG490 , Wortmannin or U0126 , respectively , *reduced* leptin induced [cyclin D1] expression and NP cell proliferation . Positive_regulation CCND1 AKT3 23388457 2748204 We recently demonstrated that a moderate level of long-term fractionated radiation confers acquired radioresistance to tumor cells , which is caused by *mediated* [cyclin D1] overexpression . Positive_regulation CCND1 AKT3 24737397 2943097 Mechanistically , aberrant PRL-3 expression promoted cell cycle progression and enhanced the antiapoptotic machinery of AML cells to drug cytotoxicity through downregulation of p21 and upregulation of [Cyclin D1] and CDK2 and *activation* of STAT5 and . Positive_regulation CCND1 ANGPT1 16061664 1439062 *up-regulated* the expression of [cyclin D1] in both of these cells . Positive_regulation CCND1 ANGPT2 10843991 721993 also *induced* [cyclin D1] protein expression in a phosphatidylinositol 3-kinase and mitogen activated protein kinase/extracellular signal regulated kinase ( MAPK/ERK ) -dependent manner . Positive_regulation CCND1 ANGPT2 10843991 721995 Using a pharmacological and a co-transfection approach , we found that p21(ras) , Raf-1 , phosphatidylinositol 3-kinase and also the catalytic activity of SHP-2 and its Src homology 2 domains are required for [cyclin D1] promoter/reporter gene *activation* by through the regulation of MAPK/ERK activity . Positive_regulation CCND1 ANGPT2 10952156 724015 Western blot analysis revealed that *stimulated* [cyclin D1] , D2 , D3 and A protein levels in cardiac myocytes . Positive_regulation CCND1 ANGPT2 11502738 868189 We recently reported that in these cells , *induced* [cyclin D1] promoter activation and protein expression in a phosphatidylinositol 3-kinase (PI3K)- , SHP-2- , and mitogen activated protein kinase/extracellular signal regulated kinase ( MAPK/ERK ) -dependent manner ( Guillemot , L. , Levy , A. , Zhao , Z. J. , Béréziat , G. , and Rothhut , B. ( 2000 ) J. Biol. Chem. 275 , 26349-26358 ) . Positive_regulation CCND1 ANGPT2 11502738 868191 Mutational analysis in the -136 to -96 bp region provided evidence that a Sp1/early growth response protein (Egr) motif was responsible for [cyclin D1] promoter *activation* by . Positive_regulation CCND1 ANGPT2 17219409 1717826 also *increased* the protein levels of [cyclin D1] , cyclin E , cyclin dependent kinase (CDK) 2 , and CDK4 but decreased the p21(cip1/waf1) and p27 ( kip1 ) , CDK inhibitory proteins . Positive_regulation CCND1 ANXA1 14516791 1147195 In summary , overexpression of mediates the disruption of normal cell morphology and *inhibits* [cyclin D1] expression , therefore reducing cell proliferation through proximal modulation of the ERK signal transduction pathway . Positive_regulation CCND1 ANXA6 19801633 2164105 In addition , we clarified that ( s6k ) is also *involved* in B [ a ] PDE induced [cyclin D1] expression because rampamycin pretreatment dramatically reduced cyclin D1 induction by B [ a ] PDE . Positive_regulation CCND1 AOM 20681671 2298961 It was also found that pterostilbene significantly inhibited *induced* expression of VEGF , [cyclin D1] , and MMPs in mouse colon . Positive_regulation CCND1 APC 10318916 611979 Inhibitors of beta-catenin activation , wild-type , axin , and the cytoplasmic tail of cadherin *suppressed* [cyclin D1] promoter activity in colon cancer cells . Positive_regulation CCND1 APC 19415698 2135718 While *dependent* expression of [CYCLIN D1] was observed in vivo and in vitro , expression of PPAR beta/delta was not different in colon or intestinal polyps from wild-type or Apc ( min ) heterozygous mice or in human colon cancer cell lines with mutations in APC and/or beta-CATENIN . Positive_regulation CCND1 API5 23940755 2827107 Removal of *reduces* cyclin E , cyclin A , [cyclin D1] and Cdk2 levels , causing G1 cell cycle arrest and cell cycle delay . Positive_regulation CCND1 APLN 18508473 1918062 Similarly , treatment with PD98059 partially diminished the *induced* expression of [cyclin D1] and vascular smooth muscle cell proliferation . Positive_regulation CCND1 APLN 20539939 2271679 PI3K inhibitor LY294002 significantly decreased the expression of phospho-PI3K , phospho-Akt , phospho-ERK1/2 , and [cyclin D1] *induced* by . Positive_regulation CCND1 APOB 22157260 2579764 In addition , AN07 acts synergistically with rosiglitazone and pioglitazone to inhibit the *induced* proliferation of human aortic smooth muscle cells and upregulation of [cyclin D1] , cyclin D3 , IL-1ß , and IL-6 . Positive_regulation CCND1 APP 18438935 1938501 Treatment with lithium chloride ( a glycogen synthase kinase-3beta inhibitor ) down-regulated cyclin B1 induced by Swe-APP expression but up-regulated [cyclin D1] expression *induced* by , suggesting that glycogen synthase kinase-3beta activity is involved in these expression changes of cyclins D1 and B1 . Positive_regulation CCND1 APP 18438935 1938502 The finding that [cyclin D1] and B1 expressions were *up-regulated* by in in vitro cultured cells was substantiated in the brain tissues of Tg2576 mice , which harbor the Swe-APP mutation . Positive_regulation CCND1 ARF1 22860097 2640985 also *induces* the expression of the proto-oncogene [cyclin D1] , which is most often associated with a transition from G1-S phase and is highly expressed in breast cancers with poor clinical prognosis . Positive_regulation CCND1 ARF3 22860097 2640986 also *induces* the expression of the proto-oncogene [cyclin D1] , which is most often associated with a transition from G1-S phase and is highly expressed in breast cancers with poor clinical prognosis . Positive_regulation CCND1 ARF4 22860097 2640987 also *induces* the expression of the proto-oncogene [cyclin D1] , which is most often associated with a transition from G1-S phase and is highly expressed in breast cancers with poor clinical prognosis . Positive_regulation CCND1 ARF5 22860097 2640988 also *induces* the expression of the proto-oncogene [cyclin D1] , which is most often associated with a transition from G1-S phase and is highly expressed in breast cancers with poor clinical prognosis . Positive_regulation CCND1 ARF6 22860097 2640989 also *induces* the expression of the proto-oncogene [cyclin D1] , which is most often associated with a transition from G1-S phase and is highly expressed in breast cancers with poor clinical prognosis . Positive_regulation CCND1 ARHGEF2 19730435 2139507 and ZONAB are required for expression of endogenous cyclin D1 , a crucial RhoA signalling target gene , and GEF-H1 stimulated [cyclin D1] promoter activity *requires* ZONAB . Positive_regulation CCND1 ATF1 11375399 834906 3 *induces* DNA synthesis and expression of [cyclin D1] in hepatocytes . Positive_regulation CCND1 ATF1 11850817 913060 We here report that HGF/SF can induce [cyclin D1] expression in mouse melanoma cells , and that this up-regulation is *mediated* in part by the ( ATF-2 ) . Positive_regulation CCND1 ATF2 10500157 648048 Both c-Jun and *transactivated* the [cyclin D1] promoter in transient transfection experiments , and a clear additional increase was detected when ER was cotransfected with either c-Jun or with c-Jun and ATF-2 but not with ATF-2 alone . Positive_regulation CCND1 ATF2 10500157 648053 To interpret these results , we propose a mechanism in which heterodimers bind to the CRE-D1 element and *mediate* the activation of [cyclin D1] promoter by the ER . Positive_regulation CCND1 ATF2 11375399 834907 3 *induces* DNA synthesis and expression of [cyclin D1] in hepatocytes . Positive_regulation CCND1 ATF2 11410592 843021 These results contrasted to a recent report showing that induction of [cyclin D1] by E2 in ER-positive MCF-7 and HeLa cells was *due* to up-regulation of c-jun and subsequent interaction of with the CRE . Positive_regulation CCND1 ATF2 11850817 913061 We here report that HGF/SF can induce [cyclin D1] expression in mouse melanoma cells , and that this up-regulation is *mediated* in part by the ( ATF-2 ) . Positive_regulation CCND1 ATF2 15691880 1371469 Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on [cyclin D1] *involving* the transcription factor in MCF-7 breast cancer cells . Positive_regulation CCND1 ATF2 16405968 1513279 [Cyclin D1] *activation* through in Reg induced pancreatic beta-cell regeneration . Positive_regulation CCND1 ATF2 16405968 1513280 The *induced* [cyclin D1] promoter activation was attenuated by PI(3)K inhibitors such as LY294002 and wortmannin . Positive_regulation CCND1 ATF3 11375399 834908 3 *induces* DNA synthesis and expression of [cyclin D1] in hepatocytes . Positive_regulation CCND1 ATF3 11375399 834922 These results indicate that ATF3 expression stimulates hepatocellular proliferation , suggesting that this effect is mediated , at least in part , by the *dependent* activation of [cyclin D1] transcription . Positive_regulation CCND1 ATF3 11850817 913062 We here report that HGF/SF can induce [cyclin D1] expression in mouse melanoma cells , and that this up-regulation is *mediated* in part by the ( ATF-2 ) . Positive_regulation CCND1 ATF3 16984628 1628228 Our data suggest that transcriptional induction of the gene in maturing chondrocytes *results* in down-regulation of [cyclin D1] and cyclin A expression as well as activation of RUNX2 dependent transcription . Positive_regulation CCND1 ATF3 23591848 2773225 Interestingly , we observed that SUMOylation is essential for mediated [CCND1/2] *activation* . Positive_regulation CCND1 ATF4 11375399 834909 3 *induces* DNA synthesis and expression of [cyclin D1] in hepatocytes . Positive_regulation CCND1 ATF4 11850817 913063 We here report that HGF/SF can induce [cyclin D1] expression in mouse melanoma cells , and that this up-regulation is *mediated* in part by the ( ATF-2 ) . Positive_regulation CCND1 ATF5 11375399 834910 3 *induces* DNA synthesis and expression of [cyclin D1] in hepatocytes . Positive_regulation CCND1 ATF5 11850817 913064 We here report that HGF/SF can induce [cyclin D1] expression in mouse melanoma cells , and that this up-regulation is *mediated* in part by the ( ATF-2 ) . Positive_regulation CCND1 ATF6 11375399 834911 3 *induces* DNA synthesis and expression of [cyclin D1] in hepatocytes . Positive_regulation CCND1 ATF6 11850817 913065 We here report that HGF/SF can induce [cyclin D1] expression in mouse melanoma cells , and that this up-regulation is *mediated* in part by the ( ATF-2 ) . Positive_regulation CCND1 ATF7 11375399 834912 3 *induces* DNA synthesis and expression of [cyclin D1] in hepatocytes . Positive_regulation CCND1 ATF7 11850817 913066 We here report that HGF/SF can induce [cyclin D1] expression in mouse melanoma cells , and that this up-regulation is *mediated* in part by the ( ATF-2 ) . Positive_regulation CCND1 ATM 23776433 2802208 Further experiments demonstrated that *up-regulated* [cyclin D1] and c-Myc expression independent of wnt/ß-catenin or p53 signaling pathway . Positive_regulation CCND1 ATP5O 23028124 2702543 a1 isoform mediates ouabain *induced* expression of [cyclin D1] and proliferation of rat sertoli cells . Positive_regulation CCND1 ATR 18606783 1947252 We found that , activated by either UV irradiation or the topoisomerase IIbeta binding protein 1 activator , *promoted* [cyclin D1] phosphorylation . Positive_regulation CCND1 ATR 18606783 1947253 Small interfering RNA against ATR inhibited UV-induced Thr286 phosphorylation , together with that seen in normally cycling cells , indicating that *regulates* [cyclin D1] phosphorylation in normal as well as stressed cells . Positive_regulation CCND1 ATR 19903334 2166089 The ATM and inhibitors CGK733 and caffeine *suppress* [cyclin D1] levels and inhibit cell proliferation . Positive_regulation CCND1 AXIN1 10318916 611980 Inhibitors of beta-catenin activation , wild-type adenomatous polyposis coli , , and the cytoplasmic tail of cadherin *suppressed* [cyclin D1] promoter activity in colon cancer cells . Positive_regulation CCND1 AXIN2 10318916 611981 Inhibitors of beta-catenin activation , wild-type adenomatous polyposis coli , , and the cytoplasmic tail of cadherin *suppressed* [cyclin D1] promoter activity in colon cancer cells . Positive_regulation CCND1 BAMBI 18838381 1988260 Finally we show that *promotes* the expression of c-myc and [cyclin D1] and increases Wnt promoted cell cycle progression . Positive_regulation CCND1 BARX2 20657655 2293378 expression in C2C12 myotubes *increased* the expression of [cyclin D1] , which may promote cell cycle re-entry . Positive_regulation CCND1 BAX 18386789 1893160 Proliferating cell nuclear antigen ( PCNA ) , [cyclin D1] and Bcl-2 expression decreased , and expression and nuclear fragmentation *increased* with increasing dietary beta-ionone . Positive_regulation CCND1 BAX 9568392 501303 When neurons are deprived of trophic factors , a sequence of events is initiated , which includes a reduction in macromolecule synthesis , elevation of c-Jun and [cyclin D1] , and *activation* of . Positive_regulation CCND1 BCAR3 14583477 1158984 , a GDP exchange factor whose overexpression confers antiestrogen resistance , *activates* Rac , PAK1 , and the [cyclin D1] promoter . Positive_regulation CCND1 BCAR3 14583477 1158992 Overexpression of the PAK1 autoinhibitory domain ( residues 83-149 ) but not an inactive PAK1 autoinhibitory domain point mutant ( L107F ) also blocked mediated [cyclin D1] *activation* . Positive_regulation CCND1 BCL2 11313702 805534 *induces* [cyclin D1] promoter activity in human breast epithelial cells independent of cell anchorage . Positive_regulation CCND1 BCL3 11713278 880873 The putative oncoprotein *induces* [cyclin D1] to stimulate G ( 1 ) transition . Positive_regulation CCND1 BCL3 16940298 1627453 Up-regulation of [cyclin D1] by HBx is *mediated* by complex through kappaB site of cyclin D1 promoter . Positive_regulation CCND1 BCL3 16940298 1627469 From these results , we conclude that the up-regulation of [cyclin D1] by HBx is *mediated* by the up-regulation of NF-kappaB2 ( p52 ) in the nucleus . Positive_regulation CCND1 BCL3 19124656 2025088 As a direct consequence of CYLD repression , the translocates into the nucleus and *activates* [Cyclin D1] and N-cadherin promoters , resulting in proliferation and invasion of melanoma cells . Positive_regulation CCND1 BCL3 20420878 2267947 Moreover , we further demonstrated that complex formation *enhanced* [cyclin D1] expression through the cyclin D1 gene promoter via its kappaB site . Positive_regulation CCND1 BCL3 20420878 2267949 The up-regulation of [cyclin D1] *mediated* by the complex in response to low concentration arsenite might be important in assessing the health risk of low concentration arsenite and understanding the mechanisms of the harmful effects of arsenite . Positive_regulation CCND1 BDNF 17404514 1735986 Both NGF and *increase* the expression of [cyclin D1] and cyclin dependent kinase 4 (cdk4) , with temporal expression patterns that parallel the proliferation kinetics of their cellular targets . Positive_regulation CCND1 BGLAP 17693256 1782052 Ex vivo , can *stimulate* [CyclinD1] and Insulin expression in beta-cells and Adiponectin , an insulin sensitizing adipokine , in adipocytes ; Positive_regulation CCND1 BHLHE40 23423709 2787266 Knockdown of DEC1 resulted in the upregulation of cyclin D1 , and overexpression of *led* to the downregulation of [cyclin D1] . Positive_regulation CCND1 BHLHE41 20821348 2447326 Finally , we demonstrated that overexpression of dramatically inhibited cell proliferation and *repressed* the expression of [cyclin D1] in human mammary epithelial cells . Positive_regulation CCND1 BMP1 24022823 2873815 Furthermore , the blocking of signaling *attenuated* the IL-10 mediated induction of [cyclin D1] and RUNX-2 in primary chondrocytes and suppressed Alcian blue and alkaline phosphatase staining in mesenchymal cell micromass cultures . Positive_regulation CCND1 BMP10 24022823 2873823 Furthermore , the blocking of signaling *attenuated* the IL-10 mediated induction of [cyclin D1] and RUNX-2 in primary chondrocytes and suppressed Alcian blue and alkaline phosphatase staining in mesenchymal cell micromass cultures . Positive_regulation CCND1 BMP15 24022823 2873816 Furthermore , the blocking of signaling *attenuated* the IL-10 mediated induction of [cyclin D1] and RUNX-2 in primary chondrocytes and suppressed Alcian blue and alkaline phosphatase staining in mesenchymal cell micromass cultures . Positive_regulation CCND1 BMP2 24022823 2873817 Furthermore , the blocking of signaling *attenuated* the IL-10 mediated induction of [cyclin D1] and RUNX-2 in primary chondrocytes and suppressed Alcian blue and alkaline phosphatase staining in mesenchymal cell micromass cultures . Positive_regulation CCND1 BMP3 24022823 2873818 Furthermore , the blocking of signaling *attenuated* the IL-10 mediated induction of [cyclin D1] and RUNX-2 in primary chondrocytes and suppressed Alcian blue and alkaline phosphatase staining in mesenchymal cell micromass cultures . Positive_regulation CCND1 BMP4 19544418 2128785 Additionally , *increased* [cyclin D1] and decreased p27 ( kip1 ) expression values in a time dependent manner . Positive_regulation CCND1 BMP4 19544418 2128786 The increases in *induced* [ ( 3 ) H ] -thymidine incorporation and [cyclin D1] expression were inhibited by the BMP-4 receptor antagonist noggin . Positive_regulation CCND1 BMP4 19544418 2128793 Wnt1 expression was attenuated by Smad4 small interfering RNA ( siRNA ) , and *induced* [cyclin D1] expression was inhibited by Smad4 and Wnt1 siRNAs . Positive_regulation CCND1 BMP4 24022823 2873819 Furthermore , the blocking of signaling *attenuated* the IL-10 mediated induction of [cyclin D1] and RUNX-2 in primary chondrocytes and suppressed Alcian blue and alkaline phosphatase staining in mesenchymal cell micromass cultures . Positive_regulation CCND1 BMP5 24022823 2873820 Furthermore , the blocking of signaling *attenuated* the IL-10 mediated induction of [cyclin D1] and RUNX-2 in primary chondrocytes and suppressed Alcian blue and alkaline phosphatase staining in mesenchymal cell micromass cultures . Positive_regulation CCND1 BMP6 24022823 2873821 Furthermore , the blocking of signaling *attenuated* the IL-10 mediated induction of [cyclin D1] and RUNX-2 in primary chondrocytes and suppressed Alcian blue and alkaline phosphatase staining in mesenchymal cell micromass cultures . Positive_regulation CCND1 BMP7 24022823 2873822 Furthermore , the blocking of signaling *attenuated* the IL-10 mediated induction of [cyclin D1] and RUNX-2 in primary chondrocytes and suppressed Alcian blue and alkaline phosphatase staining in mesenchymal cell micromass cultures . Positive_regulation CCND1 BRCA1 16860316 1607264 *regulates* [cyclin D1] expression in breast cancer cells . Positive_regulation CCND1 BRCA1 17278098 1725713 *activates* [cyclin D1] expression in breast cancer cells by downregulating the JNK phosphatase DUSP3/VHR . Positive_regulation CCND1 BRCA1 17278098 1725716 We report here an alternate or a complementary pathway by which *activates* [Cyclin D1] expression . Positive_regulation CCND1 BRCA1 17278098 1725717 Furthermore , in 2 breast cancer cell lines that overexpress both BRCA1-IRIS and Cyclin D1 ( MCF-7 and SKBR3 ) depletion of by RNA interference *attenuated* the expression of [Cyclin D1] by elevating the expression level of VHR . Positive_regulation CCND1 BRD2 18406326 1893998 We also demonstrate that has intrinsic histone chaperone activity and is *required* for transcription of the [cyclin D1] gene in vivo . Positive_regulation CCND1 BTG2 15870875 1404884 Furthermore , overexpression of *led* to down-regulation of [cyclin D1] mRNA expression in U937 cells . Positive_regulation CCND1 BTG2 22392501 2630536 The overexpression of may *inhibit* the protein expression of [cyclin D1] , MMP-1 , and MMP-2 in A549 cells . Positive_regulation CCND1 C9orf3 22009034 2526847 Although both and holo-Lf *up-regulated* transcription of [cyclin D1] , an effector of ERK1/2 and PI3K/Akt signaling cascades , only apo-Lf initiated ERK1/2 signaling and both apo- and holo-Lf were capable of activating the PI3K/Akt signaling pathway . Positive_regulation CCND1 CA2 9353308 461463 Addition of purified calpain to PC-3-M lysates resulted in *dependent* [cyclin D1] degradation . Positive_regulation CCND1 CAMK1 16603604 1568751 In fact , H2O2 stimulated activity , CaMK inhibitors prevented H2O2 induced cyclin D1 down-modulation , and CaMK overexpression *induced* [cyclin D1] degradation . Positive_regulation CCND1 CAMK2B 9596994 506146 inhibition *reduces* [cyclin D1] levels and enhances the association of p27kip1 with Cdk2 to cause G1 arrest in NIH 3T3 cells . Positive_regulation CCND1 CAMK4 16603604 1568752 In fact , H2O2 stimulated activity , CaMK inhibitors prevented H2O2 induced cyclin D1 down-modulation , and CaMK overexpression *induced* [cyclin D1] degradation . Positive_regulation CCND1 CAPN1 9353308 461437 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Positive_regulation CCND1 CAPN10 9353308 461438 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Positive_regulation CCND1 CAPN11 9353308 461439 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Positive_regulation CCND1 CAPN12 9353308 461436 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Positive_regulation CCND1 CAPN13 9353308 461447 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Positive_regulation CCND1 CAPN14 9353308 461448 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Positive_regulation CCND1 CAPN15 9353308 461435 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Positive_regulation CCND1 CAPN2 9353308 461440 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Positive_regulation CCND1 CAPN3 9353308 461441 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Positive_regulation CCND1 CAPN5 9353308 461442 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Positive_regulation CCND1 CAPN6 9353308 461443 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Positive_regulation CCND1 CAPN7 9353308 461444 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Positive_regulation CCND1 CAPN8 9353308 461445 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Positive_regulation CCND1 CAPN9 9353308 461446 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Positive_regulation CCND1 CASP1 15585645 1345664 [Cyclin D1] degradation *involved* , a regulatory component of the Skp1/Cullin/F-box complex ; Positive_regulation CCND1 CASP3 12429973 1015150 Tetrandrine induced growth inhibition was associated with induction of Cdk inhibitor p21 , inhibition of [cyclin D1] and *activation* of . Positive_regulation CCND1 CASP3 18321638 1904421 Thio-Cl-IB-MECA induced arrest of cell cycle progression in G0/G1 phase at lower concentrations ( up to 20 microM ) and apoptotic cell death at a higher concentration ( 80 microM ) , which were manifested by down-regulation of [cyclin D1] , c-myc , and CDK4 , *activation* of and -9 , and cleavage of poly ( ADP-ribose ) polymerase ( PARP ) . Positive_regulation CCND1 CASP3 18450412 2027988 Indirubin-3-oxime induced growth inhibition was associated with induction of Cdk inhibitor p21 , inhibition of [cyclin D1] and *activation* of . Positive_regulation CCND1 CASP3 19880242 2224741 The mechanisms involved inhibition of NF-kappaB activity and consequent inhibition of Bcl-2 , [cyclin D1] and VEGF , and *activation* of . Positive_regulation CCND1 CASP3 19998418 2280763 Cell death induced by the extract of P. linteus grown on PBR was shown to be associated with the upregulation of p21 ( CIP1/WAF1 ) , the downregulation of [cyclin D1] , anti-apoptotic protein , Bcl-2 , the release of cytochrome c , and the *activation* of caspase-9 , and caspase-8 . Positive_regulation CCND1 CASP3 20418696 2246625 [Cyclin D1] , cyclin dependent kinase 4 , E2F1 , Bim , and cleaved expression *increased* at 12 h and peaked at 24 h in vitro . Positive_regulation CCND1 CASP3 22270965 2586204 The mechanism is at least partially due to the inhibition of NF-?B activity and consequent inhibition of c-Myc , COX-2 , [Cyclin D1] , Survivin , Bcl-2 and Bcl-xL , and the *activation* of . Positive_regulation CCND1 CASP8 19998418 2280764 Cell death induced by the extract of P. linteus grown on PBR was shown to be associated with the upregulation of p21 ( CIP1/WAF1 ) , the downregulation of [cyclin D1] , anti-apoptotic protein , Bcl-2 , the release of cytochrome c , and the *activation* of caspase-9 , caspase-3 and . Positive_regulation CCND1 CASP9 18321638 1904422 Thio-Cl-IB-MECA induced arrest of cell cycle progression in G0/G1 phase at lower concentrations ( up to 20 microM ) and apoptotic cell death at a higher concentration ( 80 microM ) , which were manifested by down-regulation of [cyclin D1] , c-myc , and CDK4 , *activation* of , and cleavage of poly ( ADP-ribose ) polymerase ( PARP ) . Positive_regulation CCND1 CAST 9353308 461465 Transient expression of the calpain inhibitor *increased* [cyclin D1] protein in serum starved NIH 3T3 cells . Positive_regulation CCND1 CAV1 10747899 707333 Expression of antisense *increased* [cyclin D1] levels , whereas caveolin-1 overexpression inhibited expression of the cyclin D1 gene . Positive_regulation CCND1 CAV1 20658539 2363191 FN-induced increase of protooncogenes ( c-fos , c-myc , and c-Jun ) and cell-cycle regulatory proteins ( [cyclin D1/CDK4] and cyclin E/CDK2 ) expression levels were *attenuated* by FAK siRNA or siRNA . Positive_regulation CCND1 CCDC62 19126643 2060819 More importantly , using the tet-on overexpression system , we showed that induced expression of can *enhance* the E2-regulated [cyclin D1] expression and cell growth in LNCaP cells . Positive_regulation CCND1 CCDC88A 19846872 2160293 Silencing of *attenuated* [cyclin D1/cyclin] dependent kinase 4 expression and phosphorylation of ERK1/2 and Akt , thereby affecting keratinocyte proliferation . Positive_regulation CCND1 CCK 11748587 889654 ( B ) /gastrin receptor *mediates* synergistic stimulation of DNA synthesis and [cyclin D1] , D3 , and E expression in Swiss 3T3 cells . Positive_regulation CCND1 CCK 22461029 2612915 *enhanced* cellular spreading , DNA synthesis , and [cyclin D1] expression . Positive_regulation CCND1 CCK 22461029 2612920 Chemical inhibitors of JNK and ERK pathways , dominant negative JNK and c-Jun , and c-Jun shRNA significantly inhibited CCK induced DNA synthesis , induced AP-1 *activation* , and [cyclin D1] expression . Positive_regulation CCND1 CCL2 23737530 2819871 *induced* [cyclin D1] expression as well as CDK6 and CDK4 activities , and these effects were dependent on activation of NFATc1 . Positive_regulation CCND1 CCL2 23737530 2819882 MCP1 also activated Rac1 in a time dependent manner , and depletion/inhibition of its levels/activation abrogated *induced* [NFATc1-cyclin D1-CDK6-CDK4-Pak1] signaling and , thereby , decreased HASMC F-actin stress fiber formation , migration , and proliferation . Positive_regulation CCND1 CCND1 12401721 1009336 Whole-kidney and glomerular hypertrophy caused by hyperglycemia was associated with specific G1 phase cell-cycle events : early and sustained increase in expression of and *activation* of [cyclin D1-cdk4] complexes , but no change in expression of cyclin E or cdk2 activity . Positive_regulation CCND1 CCND3 11463860 839381 Time course immunochemical and biochemical analyses of the cellular and molecular effects of 1alpha,25-dihydroxyvitamin D ( 3 ) treatment for up to 6 d revealed a dynamic chain of events , *preventing* activation of [cyclin D1/cdk4] , and loss of , which collectively lead to repression of the E2F transcription factors and thus negatively affected cyclin A protein expression . Positive_regulation CCND1 CCNE2 19564413 2117430 Estrogen regulation of *requires* [cyclin D1] but not c-Myc . Positive_regulation CCND1 CCNH 10600818 574078 Cytoplasmic [cyclin D1/Cdk4] complexes were *activated* by recombinant . Positive_regulation CCND1 CD2 20459685 2262803 While Wnt target genes ( c-Myc , cyclin D1 and ABCB1 ) were up-regulated by Cd2+ , electromobility shift assays showed *increased* TCF4 binding to [cyclin D1] and ABCB1 promoter sequences with . Positive_regulation CCND1 CD44 18806267 1987335 We now report that [cyclin D1] is the primary target of LMW-HA in human vascular smooth muscle cells , as it is for HMW-HA , and that the opposing cell cycle effects of these ligands *result* from differential regulation of signaling pathways to cyclin D1 . Positive_regulation CCND1 CDC42 11715015 881615 Thus , [cyclin D1] is *induced* in mid-G1 phase because a Rho switch couples its expression to sustained ERK activity rather than Rac and . Positive_regulation CCND1 CDC42 12773570 1095224 Inhibition of either MLCK or Rho kinase blocked sustained ERK signaling , but only Rho kinase inhibition allowed for the induction of [cyclin D1] and *activation* of cdk4 via . Positive_regulation CCND1 CDC42 12919678 1130871 Instead , specific mutation of its nuclear localization and export sequences showed that LIM kinase acts in the nucleus to suppress *dependent* [cyclin D1] expression . Positive_regulation CCND1 CDC73 15580289 1368703 Transient overexpression of wild-type , but not its Leu64Pro missense mutant implicated in parathyroid cancer and familial isolated hyperparathyroidism , inhibited cell proliferation , and *blocked* expression of [cyclin D1] , a key cell cycle regulator previously implicated in parathyroid neoplasia . Positive_regulation CCND1 CDCA2 22751440 2634468 Dissecting the molecular mechanism underlying this effect by mutagenesis , EMSA and ChIP analysis revealed that *induced* [Cyclin D1] expression requires the enhanced recruitment of the transcription factor CREB on the cyclic AMP-responsive element motif within the Cyclin D1 gene proximal promoter . Positive_regulation CCND1 CDCA3 22751440 2634469 Dissecting the molecular mechanism underlying this effect by mutagenesis , EMSA and ChIP analysis revealed that *induced* [Cyclin D1] expression requires the enhanced recruitment of the transcription factor CREB on the cyclic AMP-responsive element motif within the Cyclin D1 gene proximal promoter . Positive_regulation CCND1 CDCA4 22751440 2634470 Dissecting the molecular mechanism underlying this effect by mutagenesis , EMSA and ChIP analysis revealed that *induced* [Cyclin D1] expression requires the enhanced recruitment of the transcription factor CREB on the cyclic AMP-responsive element motif within the Cyclin D1 gene proximal promoter . Positive_regulation CCND1 CDCA5 22751440 2634471 Dissecting the molecular mechanism underlying this effect by mutagenesis , EMSA and ChIP analysis revealed that *induced* [Cyclin D1] expression requires the enhanced recruitment of the transcription factor CREB on the cyclic AMP-responsive element motif within the Cyclin D1 gene proximal promoter . Positive_regulation CCND1 CDCA7 22751440 2634472 Dissecting the molecular mechanism underlying this effect by mutagenesis , EMSA and ChIP analysis revealed that *induced* [Cyclin D1] expression requires the enhanced recruitment of the transcription factor CREB on the cyclic AMP-responsive element motif within the Cyclin D1 gene proximal promoter . Positive_regulation CCND1 CDCA8 22751440 2634473 Dissecting the molecular mechanism underlying this effect by mutagenesis , EMSA and ChIP analysis revealed that *induced* [Cyclin D1] expression requires the enhanced recruitment of the transcription factor CREB on the cyclic AMP-responsive element motif within the Cyclin D1 gene proximal promoter . Positive_regulation CCND1 CDH1 11950881 930346 Furthermore , *induced* [cyclin D1] , nuclear reduplication , and karyokinesis in the absence of cytokinesis , resulting in myocytes with two closely opposed nuclei . Positive_regulation CCND1 CDH1 18187454 1856836 Our previous studies described a pro-proliferative effect of E-cadherin in MCF10A cells , mediated by Rac , and we now show that Rac is required for [cyclin D1] mRNA *induction* by both and integrin engagement . Positive_regulation CCND1 CDH1 22728329 2627037 AS or Ly294002 , but not H-89 , decreased PKB/Akt activation as well as the nuclear localization of ß-catenin and [cyclin D1] and *increased* the plasma membrane localization of ß-catenin with , suggesting that these processes are regulated by the PKB pathway . Positive_regulation CCND1 CDH1 24001804 2862178 Therefore , suppression of expression via hypermethylation or transcriptional *activation* of c-myc and [cyclin D1] may be involved in BDCM induced cell proliferation in different tissues of male F344 rats . Positive_regulation CCND1 CDK2 11438580 833016 The loss of Cdk inhibitors is followed by upregulation of [cyclin D1] , *activation* of , and subsequent cytoskeletal disintegration . Positive_regulation CCND1 CDK2 11486031 845120 Upregulation of [cyclin D1] and *activation* of by Notch ( ic ) result in the promotion of S-phase entry . Positive_regulation CCND1 CDK2 11791184 901795 [Cyclin D1/cdk-4,6] and cyclin E/cdk-2 kinase activities decreased but kinase activity *increased* for the high expressing IGFBP-rP1/mac25 clones compared to control cells . Positive_regulation CCND1 CDK2 19549773 2103900 The activity of [cyclin D1] can be *blocked* by inhibitors , including p27 ( CDKN1B ) and p21 ( CDKN1A , which is induced by p53 ) . Positive_regulation CCND1 CDK2 23892435 2821760 Restoration of CASZ1 decreases *dependent* cyclins A and E protein levels and Cdk4/6 dependent [Cyclin D1] protein levels . Positive_regulation CCND1 CDK2 9244353 446258 We demonstrate that both [cyclin D1] and CDK4 functionally depend on active Myc to exert their potential as oncogenes and vice versa that the transforming ability of Myc *requires* functional cyclin complexes . Positive_regulation CCND1 CDK2 9570919 501663 Induction of [cyclin D1] and *activation* of by EGF were found to be diminished in the aged cells . Positive_regulation CCND1 CDK20 19672860 2144208 Consistently , overexpression *increased* [cyclin D1] expression , and furthermore , a significant correlation between expression of CCRK and cyclin D1 in ovarian carcinomas was observed ( p < 0.001 ) . Positive_regulation CCND1 CDK4 10625738 658955 [Cyclin D1] and protein *induction* in motor neurons after transient spinal cord ischemia in rabbits . Positive_regulation CCND1 CDK4 11337496 827613 However , these treatments increased [cyclin D1] , cyclin E , and p21 gene expression and *induced* the formation of active complexes but resulted in only minor increases in cyclin E-Cdk2 activity , likely due to recruitment of the cyclin dependent kinase (CDK) inhibitor p21 ( WAF1/Cip1 ) into these complexes . Positive_regulation CCND1 CDK4 12201056 982993 The protein level of did not change , but MF *induced* a decreased expression of [cyclin D1] after 24 h and 30 h exposures . Positive_regulation CCND1 CDK4 12401721 1009337 Whole-kidney and glomerular hypertrophy caused by hyperglycemia was associated with specific G1 phase cell-cycle events : early and sustained increase in expression of [cyclin D1] and *activation* of complexes , but no change in expression of cyclin E or cdk2 activity . Positive_regulation CCND1 CDK4 12811822 1102918 On the other hand , EPA inhibited activation and [cyclin D1] protein *induction* , a critical step for G1/S progression . Positive_regulation CCND1 CDK4 16699726 1584324 Cyclin D1 and are rate limiting regulators of the G1 -- > S transition and expression of [cyclin D1] is predominantly *regulated* by ERK1/2 pathway in HELF cells . Positive_regulation CCND1 CDK4 17374178 1714860 [Cyclin D1] and protein expression levels *increased* in S-HELF as compared with parental HELF . Positive_regulation CCND1 CDK4 23892435 2821761 Restoration of CASZ1 decreases Cdk2 dependent cyclins A and E protein levels and *dependent* [Cyclin D1] protein levels . Positive_regulation CCND1 CDK4 24947365 2956479 Inhibition of CDK4 enhances the gluconeogenic gene expression , whereas [cyclin D1-mediated] *activation* of represses the gluconeogenic gene-expression program in vitro and in vivo . Positive_regulation CCND1 CDK4 9247303 446400 In human cells transformed by the large T-antigen of simian virus 40 ( SV40 T-Ag ) and human tumour cell lines that lack a functional retinoblastoma gene product ( pRb ) no [cyclin D1-Cdk4] complexes can be *detected* because all the available is associated with the Cdk-inhibitor p16INK4a . Positive_regulation CCND1 CDK4 9926939 588385 Moreover , the overexpression of Rb or *reduced* the level of [TAF(II)250-cyclin D1] complex . Positive_regulation CCND1 CDK6 23892435 2821762 Restoration of CASZ1 decreases Cdk2 dependent cyclins A and E protein levels and *dependent* [Cyclin D1] protein levels . Positive_regulation CCND1 CDK6 9438386 482686 Before S phase , [cyclin D1] and levels *increased* , and expression of cyclins E and A was induced . Positive_regulation CCND1 CDK7 10600818 574079 Cytoplasmic [cyclin D1/Cdk4] complexes were *activated* by recombinant cyclin . Positive_regulation CCND1 CDK9 21847632 2524260 We found that , in lung cancer cell lines and in nude mice , Interleukin-7/Interleukin-7 receptor increased the expression of cyclin D1 and phosphorylation of c-Fos/c-Jun , *induce* c-Fos and c-Jun formation , and enhanced c-Fos/c-Jun DNA binding activity to regulate [cyclin D1] . Positive_regulation CCND1 CDKN1A 10952788 724110 Thus , FR901228 , while not directly inhibiting kinase activity , causes [cyclin D1] downregulation and a p53 independent *induction* , leading to inhibition of CDK and dephosphorylation of Rb resulting in growth arrest in the early G1 phase . Positive_regulation CCND1 CDKN1A 10995875 733650 Our results demonstrated that mimosine inhibits [cyclin D1] and *induces* expression in vivo . Positive_regulation CCND1 CDKN1A 11751903 916170 We now provide evidence that ( Cip1 ) *promotes* the nuclear accumulation of [cyclin D1] complexes via inhibition of cyclin D1 nuclear export . Positive_regulation CCND1 CDKN1A 11989975 936449 In this study , we have elucidated differential regulation of the zinc stimulated ( CiP/WAF1 ) and [cyclin D1] *activation* by inhibition of phosphoinositide 3-kinase (PI3K) . Positive_regulation CCND1 CDKN1A 12032842 948148 Inhibition of p42/p44-MAPK with the chemical inhibitor PD98059 , and activation of AKT/P70S6K and p38-MAPK with insulin , produced growth arrest ( precluding the expression of PCNA , [cyclin-D1] and retinoblastoma at the hyperphosphorylated state and *inducing* the expression of the cell cycle inhibitor ( Cip ) ) and myogenesis ( multinucleated myotubes formation and induction of creatine kinase , caveolin-3 and alpha-actin ) . Positive_regulation CCND1 CDKN1A 12872751 1114271 Although forced expression of

*caused* [cyclin D 1] nuclear accumulation , the inhibition of its nuclear export by inhibiting GSK-3 beta activity had no effect . Positive_regulation CCND1 CDKN1A 14566962 1155086 This was associated with increased protein content of [cyclin D1] and Cdk4 and decreased *activation* of ( cip1 ) and p27 ( kip1 ) . Positive_regulation CCND1 CDKN1A 14670956 1210981 ERK activation was found to be required for critical downstream effects of PKC/PKC alpha activation , including [cyclin D1] down-regulation , ( Waf1/Cip1 ) *induction* , and cell cycle arrest . Positive_regulation CCND1 CDKN1A 15640940 1349800 The proliferation arrest was accompanied by a decrease in [cyclin D1] expression and the *activation* of and p27Kip1 pathways in both cell lines . Positive_regulation CCND1 CDKN1A 15694666 1371711 Taken together , our results suggest that fibronectin stimulates lung cancer carcinoma cell growth by reducing the cyclin dependent kinase inhibitor and by *inducing* [cyclin D1] gene expression . Positive_regulation CCND1 CDKN1A 19576743 2182741 The strongest anti-leukemic activity was shown by the methanol extract , which contained apigenin , baicalein , chrysin , luteolin and wogonin , with an IpC50 of 43 microg/ml ( corresponding to 1.3mg/ml of dried plant material ) which correlated with [cyclin D1-] and Cdc25A suppression and *induction* . Positive_regulation CCND1 CDKN1A 19724864 2133969 The strongest anti-proliferative activity was determined for the petroleum ether extract with an IpC50 of approximately 5.8 microg/ml medium ( referring to 1 mg dried plant ) which correlated with [cyclin D1] suppression and *induction* . Positive_regulation CCND1 CDKN1A 19954644 2172448 Western blot results showed that the Akt phosphorylation and [cyclin D1] expression was significantly decreased ( P < 0.01 ) , and the expression of p27 ( KIP1 ) and ( WAF1/CIPI ) *increased* . Positive_regulation CCND1 CDKN1A 21312237 2398652 WIN 55,212-2 also upregulated phospho-ERK1/2 , *induced* Kip1/p27 and expression , decreased [cyclin D1] and cyclin E expression , decreased Cdk 2 , Cdk 4 , and Cdk 6 expression levels , and decreased phospho-Rb and E2F-1 expression . Positive_regulation CCND1 CDKN1A 21575346 2430307 At the saccular stage , the expression of [CyclinD1] decreased significantly and the expression *increased* significantly . Positive_regulation CCND1 CDKN1A 22001116 2522190 In contrast , ectopic overexpression of Clmn produces an increase in the cyclin dependent kinase *inhibitor* , ( Cip1 ) , a decrease in [cyclin D1] protein and an increase in hypophosphorylated Rb , showing that Clmn participates in G ( 1 ) /S arrest . Positive_regulation CCND1 CDKN1A 22814742 2692066 [Cyclin D1] degradation and *induction* contribute to growth inhibition of colorectal cancer cells induced by epigallocatechin-3-gallate . Positive_regulation CCND1 CDKN1A 23627734 2870421 We also show that increased levels due to treatment with chemotherapeutic agents *result* in increased formation and kinase activity of [cyclin D1/Cdk2] complexes , and that cyclin D1/Cdk2 complexes are able to phosphorylate a number of substrates in addition to Rb . Positive_regulation CCND1 CDKN1A 9191053 437636 Regulated ectopic expression of [cyclin D1] *induces* transcriptional activation of the cdk inhibitor gene without altering cell cycle progression . Positive_regulation CCND1 CDKN1A 9191053 437639 In summary , our results demonstrate that ectopic expression of [cyclin D1] can *induce* gene expression of the cdk inhibitor through an E2F mechanism the consequences of which are not to growth arrest cells but possibly to stabilize cyclin D1/cdk function . Positive_regulation CCND1 CDKN1B 8780883 380290 Increased expression of [cyclin D1] in a murine mammary epithelial cell line *induces* , inhibits growth , and enhances apoptosis . Positive_regulation CCND1 CDKN2A 12444543 1017442 This mitogen induced [cyclin D1-kinase] activity was *blocked* by overexpression of and resulted in the inhibition of S phase entry in p21/p27-null MEFs . Positive_regulation CCND1 CDKN2A 7970707 280083 *Activation* of the E2F transcription factor by [cyclin D1] is blocked by , the product of the putative tumor suppressor gene MTS1 . Positive_regulation CCND1 CDKN2A 9247303 446401 In human cells transformed by the large T-antigen of simian virus 40 ( SV40 T-Ag ) and human tumour cell lines that lack a functional retinoblastoma gene product ( pRb ) no [cyclin D1-Cdk4] complexes can be *detected* because all the available Cdk4 is associated with the Cdk-inhibitor . Positive_regulation CCND1 CDX2 20568120 2320373 Suppression of HNF1a and expression by small interfering RNA ( siRNA ) significantly *down-regulated* expressions of CDH17 and its downstream target [cyclin D1] and the viability of HCC cells in vitro . Positive_regulation CCND1 CELF1 24502807 2914089 Moreover , depletion of *resulted* in downregulation of cyclin B1 and upregulation of [cyclin D1] . Positive_regulation CCND1 CEND1 24312406 2877952 More specifically , functional interaction of RanBPM with either or Dyrk1B *stabilizes* [cyclin D1] in the nucleus and promotes 5-bromo-2'-deoxyuridine ( BrdU ) incorporation as a measure of enhanced cell proliferation . Positive_regulation CCND1 CHUK 12589056 1059880 PI3K dependent induction of [cyclin D1] was *blocked* by inhibitors of or beta-catenin signaling . Positive_regulation CCND1 CHUK 16260626 1478092 Constitutively active *induced* p52 , RelB , and [cyclin D1] in untransformed mammary epithelial cells . Positive_regulation CCND1 CHUK 17890319 1802492 Ikkalpha ( AA/AA ) `` knockin '' mice in which activation of IkappaB kinase alpha (IKKalpha) is prevented by replacement of activation loop serines with alanines exhibit delayed mammary gland growth during pregnancy , because activity is *required* for [cyclin D1] induction and proliferation of lobuloalveolar epithelial cells . Positive_regulation CCND1 CHUK 18650423 1960259 Of several kinases examined , inhibition of *blocked* STG28 mediated cytoplasmic sequestration and degradation of [cyclin D1] . Positive_regulation CCND1 CHUK 18792914 2008957 Moreover , the soluble nickel induced [cyclin D1] degradation is dependent on its Thr286 residue and *requires* , but not HIF-1alpha , which are both reported to be involved in cyclin D1 down-regulation . Positive_regulation CCND1 CHUK 20080131 2218713 Notably , *dependent* [Cyclin D1] regulation is unrelated to IKKbeta/NF-kappaB activity . Positive_regulation CCND1 CIB1 21312237 2398650 WIN 55,212-2 also upregulated phospho-ERK1/2 , *induced* and Cip1/WAF1/p21 expression , decreased [cyclin D1] and cyclin E expression , decreased Cdk 2 , Cdk 4 , and Cdk 6 expression levels , and decreased phospho-Rb and E2F-1 expression . Positive_regulation CCND1 CISH 11024050 767729 Transcriptional activation of the [cyclin D1] gene is *mediated* by multiple , including SP1 sites and a cAMP-responsive element in vascular endothelial cells . Positive_regulation CCND1 CLDN1 22941467 2697681 In line with this , upon TNF-a stimulus , downregulation of by siRNA knockdown *results* in a significant increase in cleavage of caspase-8 and poly ( ADP-ribose ) polymerase , a decrease of [cyclinD1] expression , and DNA fragmentation . Positive_regulation CCND1 CNR2 20803555 2375244 Further downstream , activation *enhances* CREB transcriptional activity and [cyclin D1] mRNA expression . Positive_regulation CCND1 CNR2 20803555 2375248 The *induced* stimulation of CREB and [cyclin D1] is inhibitable by pertussis toxin , the MEK-Erk1/2 inhibitors PD098059 and U0126 , and Mapkapk2 siRNA . Positive_regulation CCND1 CNTN2 11992406 938694 Compared to uninfected cells , higher expression levels of cyclin D1 and D2 mRNA were detected in HTLV-I infected T-cell lines , which were at least in part mediated by the viral transforming protein Tax since *activated* both [cyclin D1] and D2 promoters in the human T-cell line Jurkat . Positive_regulation CCND1 CNTN2 11992406 938695 Inhibitors of NF-kappaB ( dominant negative IkappaBs mutants ) suppressed dependent *activation* of [cyclin D1] and D2 promoters , indicating that Tax induced activation was mediated by NF-kappaB . Positive_regulation CCND1 CNTN2 20101207 2235469 Together , our findings support a model in which *induced* accumulation of [cyclin D1] shortens the G1 phase of the cell cycle , promotes mitotic replication of the virus , and drives selection and expansion of malignant T-cells . Positive_regulation CCND1 CORO2A 18632669 1959966 Overexpression of SMRT and *attenuated* the transcription of beta-catenin-TCF4-specific reporter gene and of [CCND1] , an endogenous beta-catenin target gene . Positive_regulation CCND1 CRABP1 14713576 1181682 overexpression *resulted* in stimulated [cyclin D1] expression indicating the dependency of this cell cycle control protein on retinoic acid metabolism . Positive_regulation CCND1 CREB1 12391146 1001668 We describe an alternative mechanism for [cyclin D1] *induction* that involves the ubiquitous POU domain protein Oct-1 . Positive_regulation CCND1 CREB1 12391146 1001676 Our observation that Oct-1 potentiates *dependent* [cyclin D1] transcriptional activity independently of Ser 133 phosphorylation and E1A-sensitive coactivator function offers a new paradigm for the regulation of cyclin D1 induction by proliferative signals . Positive_regulation CCND1 CREB1 16522741 1531501 Lastly , a transfection assay employing constitutively active or dominant negative CREB expression plasmids clearly demonstrated that was largely *involved* in both basal and EX-induced [cyclin D1] promoter activities . Positive_regulation CCND1 CREB1 17473212 1738314 Overexpression of kinase dead Akt mutant or phosphorylation-defective *inhibited* [cyclin D1] transcriptional activity . Positive_regulation CCND1 CREB1 17473212 1738320 The current study shows that Nexrutine mediated targeting of induced *activation* of [cyclin D1] prevents the progression of prostate cancer . Positive_regulation CCND1 CREB1 18957421 1995068 Forced depletion of *blocked* Bt ( 2 ) cAMP stimulated [cyclin D1] expression and basal Wnt10b gene expression . Positive_regulation CCND1 CREB1 20101207 2235464 Tax binds the [cyclin D1] promoter-proximal cyclic AMP response element ( CRE ) in the *presence* of phosphorylated ( pCREB ) in vitro , and together the Tax-pCREB complex recruits the cellular co-activator p300 to the promoter through this unconventional Tax-responsive element . Positive_regulation CCND1 CREB1 24979279 2947671 [Cyclin D1] is highly *dependent* , whereas cyclin B1 and PCNA are co-regulated by both CREB dependent and -independent mechanisms . Positive_regulation CCND1 CREB3 12391146 1001669 We describe an alternative mechanism for [cyclin D1] *induction* that involves the ubiquitous POU domain protein Oct-1 . Positive_regulation CCND1 CREB3 12391146 1001677 Our observation that Oct-1 potentiates *dependent* [cyclin D1] transcriptional activity independently of Ser 133 phosphorylation and E1A-sensitive coactivator function offers a new paradigm for the regulation of cyclin D1 induction by proliferative signals . Positive_regulation CCND1 CREB3 16522741 1531502 Lastly , a transfection assay employing constitutively active or dominant negative CREB expression plasmids clearly demonstrated that was largely *involved* in both basal and EX-induced [cyclin D1] promoter activities . Positive_regulation CCND1 CREB3 17473212 1738315 Overexpression of kinase dead Akt mutant or phosphorylation-defective *inhibited* [cyclin D1] transcriptional activity . Positive_regulation CCND1 CREB3 17473212 1738321 The current study shows that Nexrutine mediated targeting of *induced* activation of [cyclin D1] prevents the progression of prostate cancer . Positive_regulation CCND1 CREB3 18957421 1995069 Forced depletion of *blocked* Bt ( 2 ) cAMP stimulated [cyclin D1] expression and basal Wnt10b gene expression . Positive_regulation CCND1 CREB3 20101207 2235465 Tax binds the [cyclin D1] promoter-proximal cyclic AMP response element ( CRE ) in the *presence* of phosphorylated ( pCREB ) in vitro , and together the Tax-pCREB complex recruits the cellular co-activator p300 to the promoter through this unconventional Tax-responsive element . Positive_regulation CCND1 CREB3 24979279 2947672 [Cyclin D1] is highly *dependent* , whereas cyclin B1 and PCNA are co-regulated by both CREB dependent and -independent mechanisms . Positive_regulation CCND1 CREB5 12391146 1001667 We describe an alternative mechanism for [cyclin D1] *induction* that involves the ubiquitous POU domain protein Oct-1 . Positive_regulation CCND1 CREB5 12391146 1001675 Our observation that Oct-1 potentiates *dependent* [cyclin D1] transcriptional activity independently of Ser 133 phosphorylation and E1A-sensitive coactivator function offers a new paradigm for the regulation of cyclin D1 induction by proliferative signals . Positive_regulation CCND1 CREB5 16522741 1531500 Lastly , a transfection assay employing constitutively active or dominant negative CREB expression plasmids clearly demonstrated that was largely *involved* in both basal and EX-induced [cyclin D1] promoter activities . Positive_regulation CCND1 CREB5 17473212 1738313 Overexpression of kinase dead Akt mutant or phosphorylation-defective *inhibited* [cyclin D1] transcriptional activity . Positive_regulation CCND1 CREB5 17473212 1738319 The current study shows that Nexrutine mediated targeting of *induced* activation of [cyclin D1] prevents the progression of prostate cancer . Positive_regulation CCND1 CREB5 18957421 1995067 Forced depletion of *blocked* Bt ( 2 ) cAMP stimulated [cyclin D1] expression and basal Wnt10b gene expression . Positive_regulation CCND1 CREB5 20101207 2235463 Tax binds the [cyclin D1] promoter-proximal cyclic AMP response element ( CRE ) in the *presence* of phosphorylated ( pCREB ) in vitro , and together the Tax-pCREB complex recruits the cellular co-activator p300 to the promoter through this unconventional Tax-responsive element . Positive_regulation CCND1 CREB5 24979279 2947670 [Cyclin D1] is highly *dependent* , whereas cyclin B1 and PCNA are co-regulated by both CREB dependent and -independent mechanisms . Positive_regulation CCND1 CRK 10066798 593769 pp60 ( v-src ) induction of [cyclin D1] *requires* collaborative interactions between the extracellular signal regulated kinase , , and Jun kinase pathways . Positive_regulation CCND1 CRK 11850817 913091 However , transcriptional up-regulation of cyclin D1 by HGF/SF was partially inhibited by the kinase-specific inhibitor , and [cyclin D1] protein induction was partially *blocked* by a dominant negative ATF-2 mutant . Positive_regulation CCND1 CRKL 22753141 2853497 Further analysis of cell cycle related molecules showed that *induced* [cyclin D1] , cyclin B1 expression , and increased Rb phosphorylation . Positive_regulation CCND1 CRKL 24375195 2932622 Further study demonstrated that upregulation *increased* [cyclin D1] expression and ERK phosphorylation . Positive_regulation CCND1 CRYGEP 14999682 1216793 We also found that ( 4 ) administration in IL-6 ( -/- ) mice failed to induce OSM expression and that OSM administration in IL-6 ( -/- ) mice after CCl ( 4 ) injection *induced* the expression of [cyclin D1] and proliferating cell nuclear antigen , suggesting that OSM is a key mediator of IL-6 in liver regeneration . Positive_regulation CCND1 CSE 19207549 2079398 stimulated cell proliferation , *increased* the protein level of [cyclin D(1)] in a dose dependent manner ( P < 0.01 ) , and decreased the proportion of G ( 0 ) /G ( 1 ) phase cell of cell cycle . Positive_regulation CCND1 CSE 21465534 2448220 Two percent and PMA significantly *enhanced* [cyclin D1] expression and cells proliferation . Positive_regulation CCND1 CSE 22166648 2366568 Moreover , Gö 6976 or PKCa siRNA significantly suppressed *induced* upregulation of [cyclin D1] at both the mRNA and protein levels . Positive_regulation CCND1 CSF1 1483347 208267 In macrophages , [cyclin D1] is *induced* early in G1 and is expressed throughout the cell cycle as long as is present . Positive_regulation CCND1 CSF1 9372970 464723 When we transfected cells expressing CSF-1R ( Y809F ) with mPIP5K-Ibeta ( delta1-238 ) , *dependent* induction of c-MYC and [cyclin D1] was restored and ligand dependent cell proliferation was sustained . Positive_regulation CCND1 CSF1 9722538 528901 Previously we showed that the macrophage activating agent lipopolysaccharide (LPS) blocks *induced* proliferation and [cyclin D1] expression in macrophages . Positive_regulation CCND1 CSF2 9891045 586274 Activation of the human receptor in NIH 3T3 cells *leads* to activation of the mitogen activated protein (MAP) kinase pathway and induced expression of c-Fos , c-Myc , and [cyclin D1] , leading to a potent mitogenic response . Positive_regulation CCND1 CSK 18550772 1940647 EGFR and activities were also *required* for E2-induced [cyclin D1] and c-myc mRNA . Positive_regulation CCND1 CTDP1 15226187 1301798 Our results suggest a model where bound at IgH regulatory sequences can *activate* the [cyclin D1] promoter by either long-range polymerase transfer or tracking . Positive_regulation CCND1 CTGF 15924723 1414107 ( 4 ) Ten nmol/L Lipoxin A ( 4 ) antagonized *induced* increase of [cyclin D(1)] protein expression in HLF and HLF/LRLP . Positive_regulation CCND1 CTGF 16141446 1499318 LXA4 downregulated the *stimulated* HLF proliferation and expression of [cyclin D1] ; Positive_regulation CCND1 CTNNB1 10201372 605416 *regulates* expression of [cyclin D1] in colon carcinoma cells . Positive_regulation CCND1 CTNNB1 10318916 611978 Inhibitors of activation , wild-type adenomatous polyposis coli , axin , and the cytoplasmic tail of cadherin *suppressed* [cyclin D1] promoter activity in colon cancer cells . Positive_regulation CCND1 CTNNB1 10318916 611982 [Cyclin D1] protein levels were *induced* by overexpression and reduced in cells overexpressing the cadherin cytoplasmic domain . Positive_regulation CCND1 CTNNB1 10679386 668917 For instance the discovery that [cyclin D1] is *regulated* by allows us to tie the APC pathway to the RB pathway and cell cycle control . Positive_regulation CCND1 CTNNB1 10775268 686545 beta-catenin and p300 also synergize to stimulate a synthetic reporter gene construct , whereas *activation* of the [cyclin D1] promoter by is refractory to p300 stimulation . Positive_regulation CCND1 CTNNB1 11266469 796924 PS1 deficiency results in accumulation of cytosolic beta-catenin , leading to a *dependent* increase in [cyclin D1] transcription and accelerated entry into the S phase of the cell cycle . Positive_regulation CCND1 CTNNB1 11401329 824427 However , tyrosine phosphorylation of does not change its binding affinity to LEF-1 nor *enhance* [cyclin D1] transactivation , a nuclear target of beta-catenin/LEF-1 . Positive_regulation CCND1 CTNNB1 11861424 917243 *activated* [cyclin D1] , and this activation was partially blocked with loss of Tcf-4 . Positive_regulation CCND1 CTNNB1 11956582 931206 Uncomplexed binds to TCF/LEF transcription factors and *activates* the expression of growth regulatory target genes such as c-myc or [cyclin D1] . Positive_regulation CCND1 CTNNB1 12530573 1028389 Nuclear *enhances* transcriptional activity of the [cyclin D1] gene in cancer cells . Positive_regulation CCND1 CTNNB1 12589056 1059881 PI3K dependent induction of [cyclin D1] was *blocked* by inhibitors of PI3K/Akt/IkappaB/IKKalpha or signaling . Positive_regulation CCND1 CTNNB1 12663502 1074490 Although activated may bind to T cell factor (TCF) family members and transcriptionally *activate* the [cyclin D1] gene , either beta-catenin or cyclin D1 may be activated by various pathways independently of beta-catenin mutations . Positive_regulation CCND1 CTNNB1 12805222 1101597 Ectopic expression of Dab2 in NIH-3T3 mouse fibroblasts attenuates canonical mediated signaling , including accumulation of beta-catenin , activation of beta-catenin/T-cell-specific factor/lymphoid enhancer binding factor 1-dependent reporter constructs , and endogenous [cyclin D1] *induction* . Positive_regulation CCND1 CTNNB1 12951064 1137336 *mediated* transactivation of [cyclin D1] promoter is negatively regulated by thyroid hormone . Positive_regulation CCND1 CTNNB1 12951064 1137337 In the presence of T3 , *dependent* transactivation of [cyclin D1] promoter was suppressed by co-transfection of TRbeta1 . Positive_regulation CCND1 CTNNB1 15004225 1237023 Our results show that low concentrations of DCA ( 5 and 50 microM ) significantly increase tyrosine phosphorylation of , *induce* urokinase-type plasminogen activator , uPAR , and [cyclin D1] expression and enhance colon cancer cell proliferation and invasiveness . Positive_regulation CCND1 CTNNB1 15004225 1237030 Inhibition of with small interfering RNA significantly *reduced* DCA induced uPAR and [cyclin D1] expression . Positive_regulation CCND1 CTNNB1 15126340 1244818 Because [cyclin D1] is mainly *regulated* by factor (TCF) , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Positive_regulation CCND1 CTNNB1 15270885 1276485 In turn , nuclear can *increase* expression of MYC and [cyclin D1] , thus potentially altering proliferation . Positive_regulation CCND1 CTNNB1 15557752 1340897 Elevated levels in colorectal cancer result in the binding of beta-catenin to LEF-1 and *increased* transcriptional activation of the [CCND1] gene . Positive_regulation CCND1 CTNNB1 15899904 1426824 Moreover , PGE2 and mutated *stimulated* the transcription of [cyclin D1] and vascular endothelial growth factor in a synergistic fashion . Positive_regulation CCND1 CTNNB1 15921235 1413668 Expression of [cyclin D1] and c-myc genes is transcriptionally *activated* by . Positive_regulation CCND1 CTNNB1 16288056 1481239 Treatment of HT29 human colon cancer cells with EGCG ( 12.5 or 20 micromol/L at different times ) also increased protein levels of E-cadherin by 27 % to 58 % , *induced* the translocation of from nucleus to cytoplasm and plasma membrane , and decreased c-Myc and [cyclin D1] ( 20 micromol/L EGCG for 24 hours ) . Positive_regulation CCND1 CTNNB1 16465433 1523340 In support of this prediction , we observed nuclear accumulation and [cyclin D1] *induction* in breast cancer cell lines , but not in HMEC . Positive_regulation CCND1 CTNNB1 16690606 1584227 Although both TGF-beta and *stimulated* [cyclin D(1)] expression in chondrocytes , the effect of TGF-beta was inhibited with beta-catenin gene deletion or SMAD3 loss of function . Positive_regulation CCND1 CTNNB1 17079480 1642922 Nuclear localized aptamer inhibited *dependent* transcription of [cyclin D1] and c-myc in colon cancer cells ; Positive_regulation CCND1 CTNNB1 17310996 1771980 Ectopic expression of DDA3 and EB3 enhanced *dependent* transactivation and [cyclin D1] production , whereas knockdown of endogenous DDA3 or EB3 inhibited beta-catenin mediated transactivation and the ability of cells to form colonies . Positive_regulation CCND1 CTNNB1 17376431 1748340 Finally , we found that the accumulation of was *involved* in the repair of scratch wounds by promoting the expression of [cyclin D1] that linked to cell proliferation . Positive_regulation CCND1 CTNNB1 17666529 1780495 Conversely , overexpression of HIPK2 suppresses mediated transcriptional *activation* of [cyclin D1] expression . Positive_regulation CCND1 CTNNB1 17855062 1818081 In the former cases it was considered that [cyclin D1] was *induced* with activation ; Positive_regulation CCND1 CTNNB1 17875709 1796208 Finally , we show that the knockdown of Mastermind-like family proteins in colonic carcinoma cells results in cell death by affecting *induced* expression of [cyclin D1] and c-Myc . Positive_regulation CCND1 CTNNB1 19091460 2041992 The hexachlorophene modulation of Siah-1 and is independent of p53 and *results* in reduced expression of [cyclin-D1] and c-Myc ( target genes of beta-catenin ) , leading to the growth arrest of B lymphoma cells . Positive_regulation CCND1 CTNNB1 19415698 2135717 While *dependent* expression of [CYCLIN D1] was observed in vivo and in vitro , expression of PPAR beta/delta was not different in colon or intestinal polyps from wild-type or Apc ( min ) heterozygous mice or in human colon cancer cell lines with mutations in APC and/or beta-CATENIN . Positive_regulation CCND1 CTNNB1 19679878 2132936 activation occurred secondary to the inactivation of glycogen synthase kinase-3beta and an increase in levels of casein kinase 2alpha , and *led* to increased [cyclin-D1] , another known beta-catenin target . Positive_regulation CCND1 CTNNBL1 22860097 2640984 also *induces* the expression of the proto-oncogene [cyclin D1] , which is most often associated with a transition from G1-S phase and is highly expressed in breast cancers with poor clinical prognosis . Positive_regulation CCND1 CTNND1 24979278 2947656 Thus , full activation of [cyclin D1] promoter activity *requires* ß-catenin activation of TCF-lef and stabilization of specific isoforms to relieve the repression of KAISO . Positive_regulation CCND1 CXCL12 16469439 1548298 Furthermore , *increased* expression of genes such as [Ccnd1] , 2 , 3 , and c-Myc known as targets of the Wnt/beta-catenin/TCF pathway . Positive_regulation CCND1 CXCL12 24038789 2896254 mediated CK1a downregulation and *increase* in GSK3ß activity affected cell cycle through Bmi-1 downregulation , increased cyclin D1 phosphorylation , and decreased [cyclin D1] levels . Positive_regulation CCND1 CYGB 24737588 2943111 overexpression inhibited cell growth , invasion , cell cycle progression and cyclin D1 expression in SKOV3 cell line and its depletion *promoted* cell proliferation , invasion , cell cycle transition and [cyclin D1] expression . Positive_regulation CCND1 CYP19A1 16322267 1487904 overexpression also *induced* the expression of [cyclin D1] , proliferating cell nuclear antigen , and the HPV oncogenes , E6 and E7 . Positive_regulation CCND1 CYP2C9 11867622 929601 The specific inhibitor , sulfaphenazole , *prevented* both the enhanced cell proliferation and up-regulation of [cyclin D1] . Positive_regulation CCND1 CYP2C9 11867622 929602 Coexpression of wild type JNK with CYP 2C9 attenuated the *induced* increase in [cyclin D1] expression and abolished the CYP 2C9 induced proliferation response . Positive_regulation CCND1 CYP2C9 11867622 929603 In contrast , cotransfecting dominant negative JNK with CYP 2C9 restored the *mediated* up-regulation of [cyclin D1] and proliferation . Positive_regulation CCND1 DACH1 22405764 2577283 Furthermore , significantly *increased* the expression of [cyclin D1] , D3 , F , and Cdk 1 , 4 , and 6 in myeloid progenitor cells . Positive_regulation CCND1 DDT 9049186 416926 [Cyclin D1] protein synthesis was *increased* by and estradiol in MCF-7 cells . Positive_regulation CCND1 DEGS1 19263436 2135396 In this article , we found that ( DEGS1 ) *up-regulated* the expression of [cyclin D1] and the activation of transcription factor NF-kappaB was essential for DEGS1 induced cyclin D1 production . Positive_regulation CCND1 DEGS1 19263436 2135399 Our results demonstrated that expression of *up-regulated* the expression of [cyclin D1] and enhanced the efficiency of tumor metastasis . Positive_regulation CCND1 DKC1 9207452 440858 There was a correlation between activity , cell cycle status by BrdU incorporation , and *induction* of phosphorylated retinoblastoma protein , CDC2 , CDK2 , [cyclin D1] , and cyclin A , but not cyclin E and B1 after 72 hours with multiple ( but not single ) cytokines . Positive_regulation CCND1 DLX4 22623533 2614748 mediated inhibition of aberrantly active Stat3 in tumor cells *suppresses* the expression of c-Myc , [Cyclin D1] , Bcl-xL , Survivin , VEGF , and Krüppel-like factor 8 , which is identified as a Stat3 target gene that promotes Stat3 mediated breast tumor cell migration and invasion . Positive_regulation CCND1 DNAJB6 18373498 1925445 In addition , *increased* Slfn1 's effect on its downstream target [cyclin D1] in co-transfected cells . Positive_regulation CCND1 DNTT 20577923 2280433 Apoptosis was detected by *mediated* nick end labeling ( TUNEL ) technique , expression of proliferating cell nuclear antigen ( PCNA ) by immunohistochemical staining , and the expression of [cyclin D1] by in situ hybridization . Positive_regulation CCND1 DST 23810794 2828800 In parallel with its mRNA level , the protein expression of ERa was induced , and phosphorylated insulin receptor substrate-1 ( p-IRS-1 ) , phosphorylated Akt1/2/3 , and [cyclin D1] were *increased* by or E2 . Positive_regulation CCND1 DUSP1 19892016 2184621 and that induces growth arrest of osteoblasts , via inactivating pERK1/2 and down *regulating* [cyclin D1] ; Positive_regulation CCND1 DYRK1B 24312406 2877953 More specifically , functional interaction of RanBPM with either BM88/Cend1 or *stabilizes* [cyclin D1] in the nucleus and promotes 5-bromo-2'-deoxyuridine ( BrdU ) incorporation as a measure of enhanced cell proliferation . Positive_regulation CCND1 E2F1 20538716 2308244 Furthermore , down-regulation of beta1,4GalT I expression attenuates *induced* DNA synthesis and cell cycle progression as well as the expression of cell-cycle regulator [Cyclin D1] . Positive_regulation CCND1 E2F1 21478909 2475527 In addition , depletion of ARF1 or expression of ARF1T ( 31 ) N resulted in the constitutive association of pRB and , thereby stabilizing the interaction of E2F1 as well as pRB at endogenous sites of target gene promoters , *preventing* expression of E2F target genes , such as [cyclin D1] , Mcm6 and E2F1 , important for cell-cycle progression . Positive_regulation CCND1 E2F1 9584162 505030 In these studies overexpression of *inhibited* [cyclin D1-dependent] kinase activity , cyclin D1 protein levels , and promoter activity . Positive_regulation CCND1 E2F4 22357515 2520891 When suppressing AP-1 activity , the [cyclin D1] and CDK4 expression levels decreased and the expression level *increased* in curcumin plus silica group , as compared with silica group . Positive_regulation CCND1 E2F4 9584162 505032 In contrast with E2F-1 , *induced* [cyclin D1] promoter activity . Positive_regulation CCND1 ECM1 23482612 2776739 More importantly , disruption of interaction by the small protein , disintegrin *inhibited* [cyclin D1] expression and cell proliferation . Positive_regulation CCND1 ECM2 23482612 2776740 More importantly , disruption of interaction by the small protein , disintegrin *inhibited* [cyclin D1] expression and cell proliferation . Positive_regulation CCND1 EDN1 10532691 562358 ( 10 ( -7 ) M ) also *stimulated* increases in [cyclin D1] protein levels after 24 h , and in absolute cell number after 4 days . Positive_regulation CCND1 EDN1 17488338 1750645 Although the stimulation with plus calcium chloride *increased* [cyclin D1] protein levels after 4-6 h , the level of phosphorylated retinoblastoma protein did not increase , suggesting that overexpression of cyclin D1 protein may have little effect on cell cycle progression but rather act as a pro-survival factor . Positive_regulation CCND1 EDN1 23619396 2790344 *stimulates* [cyclin D1] expression in rat cultured astrocytes via activation of Sp1 . Positive_regulation CCND1 EDN1 23619396 2790345 We previously observed that *increased* the expression of [cyclin D1] protein . Positive_regulation CCND1 EDN1 23619396 2790346 Thus , we confirmed the intracellular *up-regulation* of [cyclin D1] by in rat cultured astrocytes . Positive_regulation CCND1 EDN1 23619396 2790350 These results suggest that *increases* the expression of [cyclin D1] via activation of Sp1 and induces astrocytic proliferation . Positive_regulation CCND1 EDN1 9453002 484200 Thus , *induced* [cyclin D1] expression and stimulated CDK4 activity and cell cycle progression via the A-type receptor in rat mesangial cells . Positive_regulation CCND1 EGF 10228944 610930 However , *had* no significant effect on the expression of [cyclin D1] or cyclin E . Positive_regulation CCND1 EGF 10489163 645353 In addition , 1alpha,25- ( OH ) 2D3 significantly reduced basal and *stimulated* expression of [cyclin D1] at the mRNA and protein level in primary cultures as well as in the Caco-2 cell line . Positive_regulation CCND1 EGF 10585492 571497 We conclude that in 3T3-F442A cells , 1 ) the GH-induced decrease in ErbB-2 tyrosine phosphorylation correlates with MEK1/mitogen activated protein kinase activity and 2 ) GH antagonizes *induced* DNA synthesis and [cyclin D1] expression in a pattern consistent with its alteration in ErbB-2 phosphorylation status . Positive_regulation CCND1 EGF 10927622 762523 Since transcriptional *activation* of the [cyclin D1] promoter by , E2 and TPA is independent of PI3-K activity , these findings suggest a post-transcriptional role for PI3-K in the regulation of cyclin D1 expression . Positive_regulation CCND1 EGF 10942524 721429 Perturbation of EGF activated MEK1 and PKB signal pathways by TGF-beta1 correlates with perturbation of *induced* [cyclin D1] and DNA synthesis by TGF-beta1 in C3H 10T1/2 cells . Positive_regulation CCND1 EGF 10942524 721430 In mouse C3H 10T1/2 cells , we previously reported that TGF-beta1 first delays and later potentiates EGF induced DNA synthesis corresponding to an inhibition of *induced* [cyclin D1] expression at t = 13 h . Positive_regulation CCND1 EGF 10942524 721431 We report here that in accord with DNA synthesis kinetics , TGF-beta1 initially suppresses *induced* [cyclin D1] expression then later releases the inhibition . Positive_regulation CCND1 EGF 11267961 797256 or hepatocyte growth factor (HGF) *stimulated* increase of [cyclin D1] protein after 12 hours and increased DNA content after 3 days in culture . Positive_regulation CCND1 EGF 11375998 842337 Moreover , betaVLDL plus synergistically *induce* [cyclin D1] expression and down-regulate p27 ( KIP1 ) expression . Positive_regulation CCND1 EGF 11590324 869344 *induces* [cyclin D1] in human pancreatic carcinoma : evidence for a cyclin D1-dependent cell cycle progression . Positive_regulation CCND1 EGF 11590324 869346 These results demonstrate that [cyclin D1] overexpression in the tumor cells of pancreatic carcinoma tissue is at least partly *dependent* on the mitogenic effects of signaling through the EGFR . Positive_regulation CCND1 EGF 11801540 902553 This treatment reduced *dependent* mitogenesis as well as EGFR associated phosphotyrosine levels and [cyclin D1] expression . Positive_regulation CCND1 EGF 11896588 922809 In addition , C3 blocked *stimulated* [cyclin D1] promoter activity whereas V14RhoA induced the cyclin D1 promoter and cooperated with V12Ras in cyclin D1 induction . Positive_regulation CCND1 EGF 12111702 963529 Melatonin and 2-iodomelatonin ( a melatonin receptor agonist ) attenuated *stimulated* increases in LNCaP cell proliferation and [cyclin D1] levels . Positive_regulation CCND1 EGF 12111702 963530 Androgen-sensitive prostate cancer cell proliferation may be modulated by opposite changes in [cyclin D1] levels *induced* by activated MT(1) and receptors . Positive_regulation CCND1 EGF 12668975 1075902 In epidermal growth factor (EGF) treated primary cultures of rat hepatocytes , SP600125 decreased ( 3 ) H-thymidine uptake , cyclin D1 mRNA and protein expression , and inhibited the *induced* transcription of a [cyclin D1] promoter-driven reporter gene . Positive_regulation CCND1 EGF 14767992 1207848 Extracellular ATP as low as 10 nM was sufficient to potentiate *induced* [cyclin D1] expression . Positive_regulation CCND1 EGF 15511088 1328204 Expression of Rab5 : S34N and Rin1 also block *induction* of [cyclin D1] transcription . Positive_regulation CCND1 EGF 15511088 1328206 In contrast , expression of Rin1 : delta , a natural splice variant of Rin1 lacking 47 amino acids in the Vps9p domain or Rab5 , increase both activation of Raf-Erk1/2- and [cyclin D1] transcription in *response* to . Positive_regulation CCND1 EGF 15569985 1344157 We reported previously that stimulation markedly *increased* [cyclin D1] protein expression in human bronchial epithelial ( HBE ) cells , and this was opposed by chemoprevention with all-trans-retinoic acid . Positive_regulation CCND1 EGF 15642791 1363293 We have further shown that promotion of cell proliferation , but not *induction* of [cyclin D1] gene expression , involves SLPI . Positive_regulation CCND1 EGF 15798085 1451614 In addition , *stimulated* [cyclin D1] promoter activity as well as cyclin D1 expression . Positive_regulation CCND1 EGF 15798085 1451615 Moreover , inhibition of NF-kappaB caused a pronounced reduction of *induced* [cyclin D1] promoter activity . Positive_regulation CCND1 EGF 16107508 1498910 Finally , inhibition of EGFR tyrosine kinase , PKC , Ca2+ channels , or p44/42 MAPKs attenuated *stimulated* [cyclin D1] , cyclin E , cyclin dependent kinase (CDK)2 , and CDK4 , respectively . Positive_regulation CCND1 EGF 16194364 1462860 could remarkably *enhance* [cyclin D(1)] expression about 83 % more in EGF group than that in control group and proliferation index from 0.22 to 0.31 ( P < 0.01 ) . Positive_regulation CCND1 EGF 16823772 1646064 Moreover , *increased* the CDK-2 , CDK-4 , [cyclin D1] , and cyclin E expression levels but decreased the p21 and p27 expression levels . Positive_regulation CCND1 EGF 16916940 1646403 In primary cultures of normal human thyrocytes , + serum *increased* [cyclin D1] and p21 accumulation , and it stimulated the assembly and activity of cyclin D1-CDK4-p21 complexes . Positive_regulation CCND1 EGF 19443725 2136031 *induced* increases in paxillin Ser-126 phosphorylation and [cyclin D1] expression through transient Erk1/2 phosphorylation . Positive_regulation CCND1 EGF 20126978 2207345 Moreover , whereas *increased* the phosphorylation of retinoblastoma tumor suppressor protein as well as [cyclin D1] protein expression level , pretreatment with Y27632 accelerated them . Positive_regulation CCND1 EGF 20628053 2310215 Importantly , Erk mediated serine phosphorylation of paxillin is also required for DHT induced prostate-specific antigen mRNA expression in LnCAP cells as well as *induced* [cyclin D1] mRNA expression in PC3 cells , suggesting that paxillin may regulate prostate cancer proliferation by serving as a liaison between extra-nuclear kinase signaling and intra-nuclear transcriptional signals . Positive_regulation CCND1 EGF 21505178 2458335 We also found that *induced* increased [cyclin D1] expression , which plays a critical role in bronchial hyperplasia ; Positive_regulation CCND1 EGF 21505178 2458348 Furthermore , a promoter analysis revealed that the activator protein-1 transcription factor regulates *induced* [cyclin D1] overexpression . Positive_regulation CCND1 EGF 21505178 2458360 Activator protein-1 depletion by using siRNA targeting its c-Jun component completely abrogated *induced* [cyclin D1] expression . Positive_regulation CCND1 EGF 21769958 2467172 Instead , silencing of NRD1 resulted in a reduction of overall cyclin D1 expression , a reduction of *induced* increase in [cyclin D1] expression and an increase in apoptotic cell population compared with control cells . Positive_regulation CCND1 EGF 22749963 2644445 We found that SAHA treatment resulted in the dramatic inhibition of *induced* cell transformation , [cyclin D1] protein expression and induction of G0/G1 growth arrest . Positive_regulation CCND1 EGF 22749963 2644446 Moreover , SAHA inhibited *induced* [cyclin d1] mRNA level , whereas it did not show any inhibitory effect on cyclin D1 promoter-driven luciferase reporter activity under the same experimental conditions , suggesting that SAHA may decrease cyclin D1 mRNA stability . Positive_regulation CCND1 EGF 22901803 2647434 PKM2 dependent histone H3 modifications are instrumental in *induced* expression of [cyclin D1] and c-Myc , tumor cell proliferation , cell-cycle progression , and brain tumorigenesis . Positive_regulation CCND1 EGF 22927910 2657920 at 10 ng/ml also induced phosphorylation of the MAPK/ERK and *activated* [cyclin D1] promoter activity through the Src/EGFR/STAT5 pathways but not at a higher concentration ( 500 ng/ml ) . Positive_regulation CCND1 EGF 24008581 2845915 In primary hepatocyte cultures , or TGFa binding to EGF receptor activates Erk1/2 and PI3K pathways , *induces* [cyclin D1] and thus initiates DNA synthesis . Positive_regulation CCND1 EGF 25135222 2957396 TIP30 nuclear translocation negatively regulates *dependent* [cyclin D1] transcription in human lung adenocarcinoma . Positive_regulation CCND1 EGF 25135222 2957399 Chromatin immunoprecipitation assays revealed that TIP30 negatively regulated *dependent* transcriptional activation of [CCND1] through a HDAC1 dependent mechanism . Positive_regulation CCND1 EGF 7559524 323615 *induction* of [cyclin D1] transcription , through the proximal promoter region , was antagonized by either p41MAPKi or Ets-LacZ , suggesting that ETS functions downstream of epidermal growth factor and MAPK in the context of the cyclin D1 promoter . Positive_regulation CCND1 EGF 8816905 384470 Also in contrast with TGF-beta , *causes* a strong upregulation of [cyclin D1] , while neither growth factor affects cdk4 protein levels . Positive_regulation CCND1 EGF 8816905 384472 In support of this hypothesis , TGF-beta prevents *induced* upregulation of [cyclin D1] levels , while TGF-beta is still able to induce p27 down-regulation even in the presence of EGF . Positive_regulation CCND1 EGF 9568675 501313 *induces* [cyclin D1] in a human prostate cancer cell line . Positive_regulation CCND1 EGF 9568675 501315 Western analyses demonstrated that *stimulated* [cyclin D1] protein expression 4-fold over 12 hr. Northern analyses showed a 4-fold increase in mRNA expression , peaking within 4 hr of EGF stimulation . Positive_regulation CCND1 EGF 9568675 501316 In addition , we demonstrated the involvement of the protein kinase C pathway in mediating the *induction* of [cyclin D1] . Positive_regulation CCND1 EGF 9570919 501664 *Induction* of [cyclin D1] and activation of cyclin dependent kinase 2 (CDK2) by were found to be diminished in the aged cells . Positive_regulation CCND1 EGFR 12181310 992621 In addition , 1,25 ( OH ) ( 2 ) D ( 3 ) impaired autocrine and EGF induced nuclear translocation of activated and , consequently , its binding to AT-rich DNA sequences and transcriptional *activation* of the [cyclin D1] promoter . Positive_regulation CCND1 EGFR 12825853 1104528 We propose that [cyclin D1] could be indirectly *induced* by signalling through p21 . Positive_regulation CCND1 EGFR 12867074 1112048 Certain retinoids , natural and synthetic derivatives of vitamin A , repress [cyclin D1] , but activation of the *induces* cyclin D1 . Positive_regulation CCND1 EGFR 15569985 1344156 tyrosine kinase inhibition *represses* [cyclin D1] in aerodigestive tract cancers . Positive_regulation CCND1 EGFR 17922974 1804253 stimulation markedly *increases* [cyclin D1] protein expression . Positive_regulation CCND1 EGFR 18160626 1869290 Consequently , the inhibition of Ca ( 2+ ) , PKC , , p44/42 MAPKs , or NF-kappaB *blocked* the BSA induced increases in [cyclin D1] , cyclin dependent kinase (CDK)4 , cyclin E , or CDK2 and restored the BSA induced inhibition of p21 ( WAF/Cip1 ) and p27 ( Kip1 ) expression . Positive_regulation CCND1 EGFR 20302655 2238047 TOP-FLASH and FOP-FLASH reporter assays demonstrated that the signal regulates beta-catenin transcriptional activity and *mediates* [cyclin D1] expression . Positive_regulation CCND1 EGFR 21636548 2437105 The tyrosine kinase inhibitor ( TKI ) erlotinib *represses* [cyclin D1] via different mechanisms . Positive_regulation CCND1 EGFR 21821699 2477021 activation increased ES cell proliferation , motility , and invasion and *induced* [cyclin D1] , matrix metalloproteinase (MMP) 2 , and MMP9 expression . Positive_regulation CCND1 EGLN2 24990963 2948199 We recently showed that loss of , however , also *leads* to down-regulation of [Cyclin D1] and decreased cell proliferation in a HIF independent manner . Positive_regulation CCND1 EGR1 11502738 868200 Taken together , these findings demonstrate that Ang II-induced [cyclin D1] up-regulation is *mediated* by the activation and specific interaction of with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a p21(ras)/Raf-1/MEK/ERK dependent manner , and also involves PI3K and SHP-2 . Positive_regulation CCND1 EGR1 16267018 1478969 The induction of expression and its binding to the cyclin D1 promoter were *essential* for bombesin enhanced [cyclin D1] transcription . Positive_regulation CCND1 EGR1 16267018 1478973 Taken together , bombesin induced [cyclin D1] expression in prostate cancer cells is *mediated* by activation and the interaction of Egr-1 with the Egr-1/Sp1 motif of the cyclin D1 promoter through the activation of MAPK pathway . Positive_regulation CCND1 EGR1 16926376 1672998 We recently observed that , an IEG product , was *required* for transcriptional activation of [Ccnd1] ( cyclin D1 ) gene by exendin-4 . Positive_regulation CCND1 EGR2 16872830 1613629 Furthermore , mutant *upregulates* [cyclin D1] and reduces levels of the cell cycle inhibitor , p27 . Positive_regulation CCND1 EIF4E 10763819 683921 overexpression *leads* to increased [cyclin D1] protein levels ; Positive_regulation CCND1 EIF4E 10763819 683923 Neither PML nor *cause* significant changes in [cyclin D1] mRNA levels . Positive_regulation CCND1 EIF4E 18327707 2019700 The downregulation of expression significantly *reduced* the levels of VEGF , FGF-2 and [cyclinD1] expression , suppressed cell growth , induced cell cycle arrest in G ( 0 ) /G ( 1 ) phase and subsequent apoptosis by activating caspase 3 in MCF-7 cells . Positive_regulation CCND1 EIF4E 20360945 2231847 However , inhibition of interaction by knockdown of eIF4E effectively *reduced* the levels of [cyclin D1] and HIF-1alpha but failed to induce DR5 expression , downregulate c-FLIP levels , or augment TRAIL induced apoptosis . Positive_regulation CCND1 EIF4E 7673150 322714 Thus , elevated levels of may *lead* to increased transcription of the [cyclin D1] gene , and this effect becomes visible when serum deprivation down-regulates the rate of cyclin D1 mRNA synthesis in control cells . Positive_regulation CCND1 EIF4E 8246956 237038 In these cells , increased levels of protein were closely *followed* by increases in levels of [cyclin D1] protein , but the level of cyclin D1 mRNA was not increased . Positive_regulation CCND1 EIF4E 8246956 237039 We conclude that increases in [cyclin D1] levels may *result* from increased expression of , and this regulation may be one determinant of cyclin D1 levels in the cell . Positive_regulation CCND1 EIF4E 8577715 351024 Here , we studied the mode by which *increases* the expression of [cyclin D1] and ODC . Positive_regulation CCND1 EIF4EBP3 22684010 2633429 In this study , altered <4E-BP3> ( eIF4E binding protein 3 ) expression *resulted* in profoundly affected [cyclin D1] protein levels , partially due to changes in the cytoplasmic cyclin D1 mRNA levels in both U2OS and MCF7 cells , whereas altered 4E-BP1 expression did not affect eIF4E mediated cyclin D1 mRNA export . Positive_regulation CCND1 EIF4G1 20360945 2231848 However , inhibition of interaction by knockdown of eIF4E effectively *reduced* the levels of [cyclin D1] and HIF-1alpha but failed to induce DR5 expression , downregulate c-FLIP levels , or augment TRAIL induced apoptosis . Positive_regulation CCND1 EIF4G2 20360945 2231849 However , inhibition of interaction by knockdown of eIF4E effectively *reduced* the levels of [cyclin D1] and HIF-1alpha but failed to induce DR5 expression , downregulate c-FLIP levels , or augment TRAIL induced apoptosis . Positive_regulation CCND1 EIF4G3 20360945 2231850 However , inhibition of interaction by knockdown of eIF4E effectively *reduced* the levels of [cyclin D1] and HIF-1alpha but failed to induce DR5 expression , downregulate c-FLIP levels , or augment TRAIL induced apoptosis . Positive_regulation CCND1 EP300 10567390 567679 *Activation* of the [cyclin D1] gene by the through AP-1 inhibits cellular apoptosis . Positive_regulation CCND1 EPCAM 21785818 2476530 However , in HSC-4 cells cultured as MCAs , suppression of significantly *reduced* the expression levels of [cyclin D1] . Positive_regulation CCND1 EPCAM 21785818 2476531 Nuclear localization of the cyclin D1 protein was observed in MCAs of HSC-4 cells but not in MCAs of EpCAM knockdown HSC4 cells , suggesting that *regulates* [cyclin D1] expression and localization in HSC-4 cells under anchorage independent conditions . Positive_regulation CCND1 EPHA3 10608894 575355 Furthermore , we demonstrated that activation alone *augmented* [cyclin D1] promoter/enhancer activity via its STAT5 response element in both Pa-4DeltaEtk : ER and A549 cells . Positive_regulation CCND1 EPHB2 10512860 651410 Cell attachment to fibronectin or anti-alpha5beta1 integrin is sufficient to sustain the signal and to *induce* [cyclin D1] in growth factor treated cells . Positive_regulation CCND1 EPHB2 10939590 721016 Although V12Ras was able to stimulate phosphorylation and *induce* [cyclin D1] expression in the absence of androgen , it was not sufficient to promote androgen independent cell cycle progression . Positive_regulation CCND1 EPHB2 11004713 734975 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping activation and c-Fos and [cyclin D1] *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation CCND1 EPHB2 11159909 781451 Activation of Ras and *causes* induction of [cyclin D1-Cdk4] without increase of cyclin E or PCNA in ductal lesions . Positive_regulation CCND1 EPHB2 11498792 846708 Consistently , we show that the mediated FSH mitogenic effect *triggers* upregulation of [cyclin D1] . Positive_regulation CCND1 EPHB2 11804875 903399 IFN-gamma does not interfere with the effects of HGF on either activation or [cyclin D1] *induction* ; Positive_regulation CCND1 EPHB2 12165850 972984 Differentiation induced by retinoic acid results in the gain of *dependent* control of [cyclin D1] expression and of S phase progression . Positive_regulation CCND1 EPHB2 12773570 1095220 We recently reported that Rho kinase is required for sustained signaling and the consequent mid-G ( 1 ) phase *induction* of [cyclin D1] in fibroblasts . Positive_regulation CCND1 EPHB2 12816758 1157186 Transient activation and subsequent [cyclin D1] *induction* were observed on adding 10 microM ZnCl2 in MSSM in the presence of cell proliferation . Positive_regulation CCND1 EPHB2 12816758 1157188 Moreover , this activation and [cyclin D1] and p21 ( Cip/WAF1 ) *induction* were abolished by PD-98059 pretreatment . Positive_regulation CCND1 EPHB2 12816758 1157195 The differential regulations of cell growth , activities , and [cyclin D1] and p21 ( Cip/WAF1 ) *inductions* were also observed in serum enriched medium containing higher zinc concentrations . Positive_regulation CCND1 EPHB2 14516791 1147193 Moreover , ANXA1 reduces proliferation by ERK mediated disruption of the actin cytoskeleton and ablation of [cyclin D1] protein expression and not by mediated *induction* of the cyclin dependent kinase , CDK2 , inhibitor p21 ( cip/waf ) . Positive_regulation CCND1 EPHB2 15212949 1262419 Decreasing with the pharmacological inhibitors , PD98059 and U0126 , markedly suppresses hyperoxia stimulated phospho-p53 ( Ser15 ) , p53 , and p21 ( CIP1 ) , and also *restores* the hyperoxia reduced kinase activities of [cyclin D1/E1-Cdks] . Positive_regulation CCND1 EPHB2 15277494 1277212 Activation of both and JNK/SAPK was *necessary* for the HGF stimulated induction of [cyclin D1] , which in turn was necessary for the HGF induced proliferation of LECs . Positive_regulation CCND1 EPHB2 17314399 1711559 activity *regulates* the induction of [cyclin D1] , and a sustained ERK signal is thought to be required for this effect , at least in fibroblasts . Positive_regulation CCND1 EPHB2 17426454 1736488 Inhibition of NFkappaB signaling with the IkappaB super-repressor blocked the Rac dependent expression of cyclin D1 mRNA , and this effect was selective since *dependent* [cyclin D1] mRNA induction was minimally affected by super-repressor expression . Positive_regulation CCND1 EPHB2 17941827 1849400 Heregulin beta1 promotes breast cancer cell proliferation through *dependent* induction of [cyclin D1] and p21Cip1 . Positive_regulation CCND1 EPHB2 18806267 1987336 HMW-HA binding to CD44 selectively inhibits the GTP loading of Rac and Rac dependent signaling to the cyclin D1 gene , whereas LMW-HA binding to CD44 selectively stimulates ERK activation and *dependent* [cyclin D1] gene expression . Positive_regulation CCND1 EPHB2 19847806 2184202 Our results show that activation is *necessary* but not sufficient for the induction of [cyclin D1] expression and proliferation , since the inhibition of PI3K or cPKC prevents this outcome . Positive_regulation CCND1 EPHB2 19935697 2210087 The expression of [cyclin D1] *required* both EGFR mediated and AKT activation . Positive_regulation CCND1 EPHB2 22214150 2519148 It was found that and JNK were *involved* in silica induced [cyclin D1] and CDK4 overexpression and the decreased expression of E2F-4 . Positive_regulation CCND1 EPHB2 22579115 2609536 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated [Cyclin D1] and Cyclin B1 proteins as well as *activation* of PI3K/Akt and , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation CCND1 EPHB2 22789855 2639791 Endoglin inhibits *induced* c-Myc and [cyclin D1] expression to impede endothelial cell proliferation . Positive_regulation CCND1 EPHB2 23278864 2865461 The proliferative effects of insulin-like growth factor 1 ( IGF-1 , 25 ng/ml ) on [ ( 3 ) H ] thymidine ( TdR ) incorporation into DNA and on [cyclin D1] protein expression of rumen epithelial cells were *inhibited* by PPP ( the inhibitor of type 1 IGF receptor ) ( p < 0.05 ) and inhibitor ( p < 0.05 ) in vitro . Positive_regulation CCND1 EPHB2 23300886 2712457 Pharmacological inhibition of JAK/STAT3 , PI3K/Akt or signaling by AG490 , Wortmannin or U0126 , respectively , *reduced* leptin induced [cyclin D1] expression and NP cell proliferation . Positive_regulation CCND1 EPHB2 23975425 2942265 Although inhibition *suppressed* [cyclin D1] expression , cell proliferation and stem/progenitor cell properties , it did not affect invasion or EMT . Positive_regulation CCND1 EPHB2 9407076 470833 Overexpression of dominant negative *resulted* in inhibition of PDGF induced [cyclin D1] expression but had no effect on PDGF induced p27 ( KIP1 ) degradation . Positive_regulation CCND1 EPHB2 9537433 497575 In conclusion , these findings suggest that MAPK/ERK activation in human HCC may play an important role in multistep hepatocarcinogenesis , especially in the progression of HCC; at least in part , through [cyclin D1] up-regulation primarily *induced* by via c-Fos . Positive_regulation CCND1 EPX 24004818 2866574 Mechanistic investigations revealed that *stimulates* the expression of [cyclin D1] while inhibiting the expression of p21cip1 and p27kip1 through the phosphorylation of JAK2 and ERK1/2 , leading to a more rapid progression through the cell cycle . Positive_regulation CCND1 ERBB2 20443831 2009605 *induced* [cyclin D1] and cyclin D1 expression was suficient to induce Notch1 activity , and conversely , genetic deletion of Notch1 in mammary epithelial cells using foxed Notch ( Notch ( fl/fl ) ) mice demonstrated that cyclin D1 is induced by Notch1 . Positive_regulation CCND1 ERBB3 22261253 2559716 We demonstrate here that the binding of ( 80 KDa ) on the promoter *activates* [Cyclin D1] transcription and subsequent protein expression , leading to an increased cell proliferation . Positive_regulation CCND1 ESR1 10519385 652462 Functional activity of ectopically expressed is not *sufficient* for estrogen mediated [cyclin D1] expression . Positive_regulation CCND1 ESR1 10519385 652463 In both cases , function did not *induce* [cyclin D1] expression . Positive_regulation CCND1 ESR1 10519385 652464 Therefore , function alone is not *sufficient* for estrogen dependent [cyclin D1] expression and proliferation . Positive_regulation CCND1 ESR1 11358796 816112 In this study , we evaluated whether high levels of AIB1 enable the to *direct* the transcription of [cyclin D1] . Positive_regulation CCND1 ESR1 11986316 954182 *Induction* of [cyclin D1] gene transcription by plays an important role in estrogen mediated proliferation . Positive_regulation CCND1 ESR1 15178330 1255226 activation at serine 305 is *sufficient* to upregulate [cyclin D1] in breast cancer cells . Positive_regulation CCND1 ESR1 15178330 1255227 Furthermore , , but not mutation of ER alpha-S305 to alanine , *enhanced* the [cyclin D1] promoter activity . Positive_regulation CCND1 ESR1 15178330 1255228 These findings suggest that activation at S305 is *sufficient* to upregulate the expression of [cyclin D1] , an ER-regulated gene that is implicated in the progression of breast cancer . Positive_regulation CCND1 ESR1 15313930 1285812 Moreover , ERalpha and ERbeta had opposite actions on cyclin D1 gene regulation , because ERbeta down-regulated cyclin D1 gene expression , whereas *increased* [cyclin D1] levels . Positive_regulation CCND1 ESR1 15544931 1337804 [Cyclin D1] expression is *dependent* on function in tamoxifen-resistant breast cancer cells . Positive_regulation CCND1 ESR1 15558026 1361137 The requirement of this domain for nuclear receptor repression was conserved with respect to thyroid hormone receptor beta-1 , whereas [cyclin D1] *activation* of the occurred independently of the central region . Positive_regulation CCND1 ESR1 16945332 1615527 Consequently , we asked whether RFP would modulate ESR1 activity and we discovered that RFP was important for the *dependent* expression of [cyclin D1 (CCND1)] and the progesterone receptor (PR) , but not IRS1 or MYC . Positive_regulation CCND1 ESR1 18310301 1879024 Increased expression of may *contribute* to early induction of [cyclin D1] and cyclin E during the cell cycle in bladder cancer cells . Positive_regulation CCND1 ESR1 18757415 1956554 HEXIM1 regulates <17beta-estradiol/estrogen receptor-alpha> *mediated* expression of [cyclin D1] in mammary cells via modulation of P-TEFb . Positive_regulation CCND1 ESR1 22219213 2579912 E2- or , through activation of epidermal growth factor receptor (EGFR)/mitogen activated protein kinase 3/1 ( MAPK3/1 ) and PIK3 pathways , *induces* upregulation of [CCND1] . Positive_regulation CCND1 ESR1 9039267 415706 CDK independent *activation* of by [cyclin D1] . Positive_regulation CCND1 ESR1 9039267 415708 The *activation* of by [cyclin D1] is not inhibited by anti-estrogens . Positive_regulation CCND1 ETS2 7559524 323566 Transforming p21ras mutants and *activate* the [cyclin D1] promoter through distinguishable regions . Positive_regulation CCND1 EXD1 18216022 1884000 [Cyclin D1] and c-Myc , determinants of cell proliferation , are *up-regulated* by . Positive_regulation CCND1 EXD2 18216022 1883998 [Cyclin D1] and c-Myc , determinants of cell proliferation , are *up-regulated* by . Positive_regulation CCND1 EXD3 18216022 1883999 [Cyclin D1] and c-Myc , determinants of cell proliferation , are *up-regulated* by . Positive_regulation CCND1 EYA1 23636126 2810565 The mediated transcriptional *induction* of [cyclin D1] occurred via the AP-1 binding site at -953 and required the EYA1 phosphatase function . Positive_regulation CCND1 F2RL1 23991105 2836592 Further studies showed that miRNA-34a mediated *induced* [Cyclin D1] upregulation . Positive_regulation CCND1 FABP4 24312381 2877928 We found that induced the active forms of the nuclear transcription factors c-jun and c-myc , which are regulated by MAPK cascades , and *increased* the expression of the downstream genes [cyclin D1] and MMP2 , CCL2 , and fibulin 4 and 5 , which are involved in cell cycle regulation and cell migration . Positive_regulation CCND1 FASLG 23975033 2920855 Emodin ( 72 h ) treatment could up-regulate the gene expression of ( p < 0.05 ) and down-regulate the gene expression of C-MYC ( p < 0.01 ) , but *induce* no significant changes in the gene expressions of MCL1 , GAPDH , BAX and [CCND1] . Positive_regulation CCND1 FASN 22554590 2637485 inhibitor Cer and FASN-siRNA produced the increased apoptosis and decreased proliferation of bladder cancer cells , and *caused* inactivity of AKT and downregulation of [CCND1] . Positive_regulation CCND1 FBXO31 19412162 2089851 [Cyclin D1] degradation *results* from a direct interaction with and is dependent on the F-box motif of FBXO31 and phosphorylation of cyclin D1 at Thr 286 , which is known to be required for cyclin D1 proteolysis . Positive_regulation CCND1 FBXO31 20664978 2298234 Ectopic overexpression of *resulted* in down-regulation of [cyclin D1] which leads to the accumulation of cells at the G1 phase of the cell cycle . Positive_regulation CCND1 FBXO4 18598945 1935346 Inhibition of activity *results* in accumulation of nuclear [cyclin D1] and oncogenic transformation . Positive_regulation CCND1 FBXW8 17205132 1663874 A critical *role* for and MAPK in [cyclin D1] degradation and cancer cell proliferation . Positive_regulation CCND1 FGF1 10650945 662502 Taken together , these results show that interactions *increase* [cyclin D1] expression , correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone . Positive_regulation CCND1 FGF1 9606972 508294 Here we report that both cobalt and the calcium chelator EGTA , inhibitors of calcium uptake , as well as cyclosporin A and FK-506 , specific inhibitors of calcineurin function , abolished *induced* expression of cyclins A and E , but not [cyclin D1] . Positive_regulation CCND1 FGF10 10650945 662503 Taken together , these results show that interactions *increase* [cyclin D1] expression , correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone . Positive_regulation CCND1 FGF10 9606972 508295 Here we report that both cobalt and the calcium chelator EGTA , inhibitors of calcium uptake , as well as cyclosporin A and FK-506 , specific inhibitors of calcineurin function , abolished *induced* expression of cyclins A and E , but not [cyclin D1] . Positive_regulation CCND1 FGF11 10650945 662504 Taken together , these results show that interactions *increase* [cyclin D1] expression , correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone . Positive_regulation CCND1 FGF11 9606972 508296 Here we report that both cobalt and the calcium chelator EGTA , inhibitors of calcium uptake , as well as cyclosporin A and FK-506 , specific inhibitors of calcineurin function , abolished *induced* expression of cyclins A and E , but not [cyclin D1] . Positive_regulation CCND1 FGF12 10650945 662505 Taken together , these results show that interactions *increase* [cyclin D1] expression , correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone . Positive_regulation CCND1 FGF12 9606972 508297 Here we report that both cobalt and the calcium chelator EGTA , inhibitors of calcium uptake , as well as cyclosporin A and FK-506 , specific inhibitors of calcineurin function , abolished *induced* expression of cyclins A and E , but not [cyclin D1] . Positive_regulation CCND1 FGF13 10650945 662506 Taken together , these results show that interactions *increase* [cyclin D1] expression , correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone . Positive_regulation CCND1 FGF13 9606972 508298 Here we report that both cobalt and the calcium chelator EGTA , inhibitors of calcium uptake , as well as cyclosporin A and FK-506 , specific inhibitors of calcineurin function , abolished *induced* expression of cyclins A and E , but not [cyclin D1] . Positive_regulation CCND1 FGF14 10650945 662507 Taken together , these results show that interactions *increase* [cyclin D1] expression , correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone . Positive_regulation CCND1 FGF14 9606972 508299 Here we report that both cobalt and the calcium chelator EGTA , inhibitors of calcium uptake , as well as cyclosporin A and FK-506 , specific inhibitors of calcineurin function , abolished *induced* expression of cyclins A and E , but not [cyclin D1] . Positive_regulation CCND1 FGF16 10650945 662508 Taken together , these results show that interactions *increase* [cyclin D1] expression , correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone . Positive_regulation CCND1 FGF16 9606972 508300 Here we report that both cobalt and the calcium chelator EGTA , inhibitors of calcium uptake , as well as cyclosporin A and FK-506 , specific inhibitors of calcineurin function , abolished *induced* expression of cyclins A and E , but not [cyclin D1] . Positive_regulation CCND1 FGF17 10650945 662509 Taken together , these results show that interactions *increase* [cyclin D1] expression , correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone . Positive_regulation CCND1 FGF17 9606972 508301 Here we report that both cobalt and the calcium chelator EGTA , inhibitors of calcium uptake , as well as cyclosporin A and FK-506 , specific inhibitors of calcineurin function , abolished *induced* expression of cyclins A and E , but not [cyclin D1] . Positive_regulation CCND1 FGF18 10650945 662510 Taken together , these results show that interactions *increase* [cyclin D1] expression , correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone . Positive_regulation CCND1 FGF18 9606972 508302 Here we report that both cobalt and the calcium chelator EGTA , inhibitors of calcium uptake , as well as cyclosporin A and FK-506 , specific inhibitors of calcineurin function , abolished *induced* expression of cyclins A and E , but not [cyclin D1] . Positive_regulation CCND1 FGF19 10650945 662511 Taken together , these results show that interactions *increase* [cyclin D1] expression , correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone . Positive_regulation CCND1 FGF19 9606972 508303 Here we report that both cobalt and the calcium chelator EGTA , inhibitors of calcium uptake , as well as cyclosporin A and FK-506 , specific inhibitors of calcineurin function , abolished *induced* expression of cyclins A and E , but not [cyclin D1] . Positive_regulation CCND1 FGF2 10650945 662512 Taken together , these results show that interactions *increase* [cyclin D1] expression , correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone . Positive_regulation CCND1 FGF2 12235165 1012350 Cotransfection with a dominant negative Tcf-4 construct inhibited the *induced* [cyclin D1] promoter activity . Positive_regulation CCND1 FGF2 12235165 1012352 Overexpression of an uninhibitable GSK-3beta mutant resulted in partial inhibition of mediated [cyclin D1] *induction* . Positive_regulation CCND1 FGF2 14718259 1202694 The mediated *increase* in [cyclin D1] protein levels after 8 h was reduced in the presence of 15d-PGJ2 , but not RG . Positive_regulation CCND1 FGF2 15033176 1223347 IGF-I and coordinately *enhance* [cyclin D1] and cyclin E-cdk2 association and activity to promote G1 progression in oligodendrocyte progenitor cells . Positive_regulation CCND1 FGF2 15033176 1223349 IGF-I enhanced *induction* of [cyclin D1] , activation of G ( 1 ) cyclin-cyclin dependent kinase (cdk) complexes , and hyperphosphorylation of retinoblastoma protein ( pRb ) . Positive_regulation CCND1 FGF2 17508424 1761883 Synergistic *induction* of [cyclin D1] in oligodendrocyte progenitor cells by IGF-I and requires differential stimulation of multiple signaling pathways . Positive_regulation CCND1 FGF2 17508424 1761885 In contrast , blocking the PI3-Kinase pathway results in loss of synergistic *induction* of [cyclin D1] protein levels . Positive_regulation CCND1 FGF2 17508424 1761892 Thus , we provide a model for cyclin D1 coordinate regulation where stimulation of the MAPK pathway *promotes* [cyclin D1] mRNA expression while IGF-I activation of the PI3K pathway inhibits proteasome degradation of cyclin D1 and enhances nuclear localization of cyclin D1 . Positive_regulation CCND1 FGF2 18404517 1497303 We found that ATP potentiated the ability of to *stimulate* expression of [cyclin D1] , a regulator of cell cycle entry , as well as cyclin A , a regulator of DNA replication . Positive_regulation CCND1 FGF2 22911796 2657381 Taken together , our results suggest that downregulation of p38 mediated miR-1/133 expression by and subsequent *upregulation* of [Sp1/Cyclin D1] contribute to the increased myoblast proliferation during the early stage of muscle regeneration . Positive_regulation CCND1 FGF2 7876159 298412 Expression of [cyclin D1] was *induced* in myoblasts by and TGF beta ( albeit with different kinetics for each factor ) , while induction of cyclin D3 expression was inhibited by these growth factors . Positive_regulation CCND1 FGF2 9135019 427548 *induced* an increase in [cyclin D1] , cyclin E , and cyclin dependent kinase 4 (cdk4) protein levels in a bFGF dose dependent manner . Positive_regulation CCND1 FGF2 9606972 508304 Here we report that both cobalt and the calcium chelator EGTA , inhibitors of calcium uptake , as well as cyclosporin A and FK-506 , specific inhibitors of calcineurin function , abolished *induced* expression of cyclins A and E , but not [cyclin D1] . Positive_regulation CCND1 FGF20 10650945 662513 Taken together , these results show that interactions *increase* [cyclin D1] expression , correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone . Positive_regulation CCND1 FGF20 9606972 508305 Here we report that both cobalt and the calcium chelator EGTA , inhibitors of calcium uptake , as well as cyclosporin A and FK-506 , specific inhibitors of calcineurin function , abolished *induced* expression of cyclins A and E , but not [cyclin D1] . Positive_regulation CCND1 FGF21 10650945 662514 Taken together , these results show that interactions *increase* [cyclin D1] expression , correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone . Positive_regulation CCND1 FGF21 9606972 508306 Here we report that both cobalt and the calcium chelator EGTA , inhibitors of calcium uptake , as well as cyclosporin A and FK-506 , specific inhibitors of calcineurin function , abolished *induced* expression of cyclins A and E , but not [cyclin D1] . Positive_regulation CCND1 FGF22 10650945 662515 Taken together , these results show that interactions *increase* [cyclin D1] expression , correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone . Positive_regulation CCND1 FGF22 9606972 508307 Here we report that both cobalt and the calcium chelator EGTA , inhibitors of calcium uptake , as well as cyclosporin A and FK-506 , specific inhibitors of calcineurin function , abolished *induced* expression of cyclins A and E , but not [cyclin D1] . Positive_regulation CCND1 FGF23 10650945 662516 Taken together , these results show that interactions *increase* [cyclin D1] expression , correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone . Positive_regulation CCND1 FGF23 9606972 508308 Here we report that both cobalt and the calcium chelator EGTA , inhibitors of calcium uptake , as well as cyclosporin A and FK-506 , specific inhibitors of calcineurin function , abolished *induced* expression of cyclins A and E , but not [cyclin D1] . Positive_regulation CCND1 FGF3 10650945 662517 Taken together , these results show that interactions *increase* [cyclin D1] expression , correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone . Positive_regulation CCND1 FGF3 9606972 508309 Here we report that both cobalt and the calcium chelator EGTA , inhibitors of calcium uptake , as well as cyclosporin A and FK-506 , specific inhibitors of calcineurin function , abolished *induced* expression of cyclins A and E , but not [cyclin D1] . Positive_regulation CCND1 FGF4 10650945 662518 Taken together , these results show that interactions *increase* [cyclin D1] expression , correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone . Positive_regulation CCND1 FGF4 9606972 508310 Here we report that both cobalt and the calcium chelator EGTA , inhibitors of calcium uptake , as well as cyclosporin A and FK-506 , specific inhibitors of calcineurin function , abolished *induced* expression of cyclins A and E , but not [cyclin D1] . Positive_regulation CCND1 FGF5 10650945 662519 Taken together , these results show that interactions *increase* [cyclin D1] expression , correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone . Positive_regulation CCND1 FGF5 9606972 508311 Here we report that both cobalt and the calcium chelator EGTA , inhibitors of calcium uptake , as well as cyclosporin A and FK-506 , specific inhibitors of calcineurin function , abolished *induced* expression of cyclins A and E , but not [cyclin D1] . Positive_regulation CCND1 FGF6 10650945 662520 Taken together , these results show that interactions *increase* [cyclin D1] expression , correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone . Positive_regulation CCND1 FGF6 9606972 508312 Here we report that both cobalt and the calcium chelator EGTA , inhibitors of calcium uptake , as well as cyclosporin A and FK-506 , specific inhibitors of calcineurin function , abolished *induced* expression of cyclins A and E , but not [cyclin D1] . Positive_regulation CCND1 FGF7 10650945 662521 Taken together , these results show that interactions *increase* [cyclin D1] expression , correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone . Positive_regulation CCND1 FGF7 9606972 508313 Here we report that both cobalt and the calcium chelator EGTA , inhibitors of calcium uptake , as well as cyclosporin A and FK-506 , specific inhibitors of calcineurin function , abolished *induced* expression of cyclins A and E , but not [cyclin D1] . Positive_regulation CCND1 FGF8 10650945 662522 Taken together , these results show that interactions *increase* [cyclin D1] expression , correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone . Positive_regulation CCND1 FGF8 19962979 2210396 Blocking the constitutively active PI3K/Akt and p38 MAPK pathways also lowered *induced* [cyclin D1] expression and proliferation . Positive_regulation CCND1 FGF8 19962979 2210397 In S115 and MCF-7 mouse tumours , *increased* [cyclin D1] and Ki67 levels . Positive_regulation CCND1 FGF8 9606972 508314 Here we report that both cobalt and the calcium chelator EGTA , inhibitors of calcium uptake , as well as cyclosporin A and FK-506 , specific inhibitors of calcineurin function , abolished *induced* expression of cyclins A and E , but not [cyclin D1] . Positive_regulation CCND1 FGF9 10650945 662523 Taken together , these results show that interactions *increase* [cyclin D1] expression , correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone . Positive_regulation CCND1 FGF9 9606972 508315 Here we report that both cobalt and the calcium chelator EGTA , inhibitors of calcium uptake , as well as cyclosporin A and FK-506 , specific inhibitors of calcineurin function , abolished *induced* expression of cyclins A and E , but not [cyclin D1] . Positive_regulation CCND1 FGFR1 19009564 2078980 but not FGFR4 *induced* [cyclin D1] and repressed p27 expression . Positive_regulation CCND1 FGFR4 19009564 2078981 FGFR1 but not *induced* [cyclin D1] and repressed p27 expression . Positive_regulation CCND1 FHL2 18378678 1912980 The LIM-only protein *regulates* [cyclin D1] expression and cell proliferation . Positive_regulation CCND1 FHL2 18378678 1912982 Reexpression of FHL2 in FHL2-null fibroblasts efficiently restores cyclin D1 levels and cell proliferative capacity , indicating that is *critical* for [cyclin D1] activation and cell growth . Positive_regulation CCND1 FHL2 19018287 1992044 We reported previously that *regulates* [cyclin D1] expression and that immortalized FHL2-null mouse embryo fibroblasts ( MEFs ) display reduced levels of cyclin D1 and low proliferative activity . Positive_regulation CCND1 FLCN 23525507 2767019 *regulates* [cyclin D1] expression through cis acting elements in the 3 ' untranslated region of cyclin D1 mRNA . Positive_regulation CCND1 FLI1 15342383 1291921 In contrast , induction of expression in the RD RMS cell line *increased* [cyclin D1] expression but decreased cyclin D3 expression . Positive_regulation CCND1 FLI1 18271016 1911576 In this report , we show that depletion of in Ewing 's cell lines *results* in a senescence phenotype , a marked increase in expression of the G1/S regulatory proteins p27 ( kip1 ) and p57(kip2) , and a significant decrease in [cyclin D1] and CDK2 . Positive_regulation CCND1 FOS 19847806 2184201 Thrombin stimulates RPE cell proliferation by promoting *mediated* [cyclin D1] expression . Positive_regulation CCND1 FOS 19847806 2184203 Analysis of thrombin activated PAR-1 downstream effectors demonstrated that expression by the sustained activation of ERK and c-fos transcription *triggers* the expression and nuclear translocation of [cyclin D1] , a key regulator of cell cycle G1/S phase progression leading to proliferation . Positive_regulation CCND1 FOS 21847632 2524261 We found that , in lung cancer cell lines and in nude mice , Interleukin-7/Interleukin-7 receptor increased the expression of cyclin D1 and phosphorylation of c-Fos/c-Jun , *induce* and c-Jun heterodimer formation , and enhanced c-Fos/c-Jun DNA binding activity to regulate [cyclin D1] . Positive_regulation CCND1 FOS 9710644 526961 Although definitive evidence that and FosB directly *induce* [cyclin D1] transcription will require further analysis , these findings raise the possibility that c-Fos and FosB are either direct or indirect transcriptional regulators of the cyclin D1 gene and may function as a critical link between serum stimulation and cell cycle progression . Positive_regulation CCND1 FOSB 9710644 526962 Although definitive evidence that c-Fos and directly *induce* [cyclin D1] transcription will require further analysis , these findings raise the possibility that c-Fos and FosB are either direct or indirect transcriptional regulators of the cyclin D1 gene and may function as a critical link between serum stimulation and cell cycle progression . Positive_regulation CCND1 FOXM1 11682060 873989 Quantitation of cyclin B1 and D1 levels using flow cytometric , Western and Northern analyses reveals that elevated levels *lead* to stimulation of cyclin B1 but not [cyclin D1] expression . Positive_regulation CCND1 FOXM1 18206647 1870576 In contrast , we now demonstrate that this LXL-motif is not required for the *activation* of by [cyclin D1/Cdk4] , cyclin E/Cdk and cyclin A/Cdk2 or for the repression of FOXM1c by p27 . Positive_regulation CCND1 FOXM1 23333330 2747086 They defined 12 Cdk consensus sites as essential for the *activation* of by [cyclinD1/Cdk4] and cyclinD3/Cdk6 and stated that the 12 Cdk-sites are positioned within the TAD of FOXM1c . Positive_regulation CCND1 FOXM1 23333330 2747094 This study shows that the *activation* of by [cyclinD1/Cdk4] is lost without removal of any cyclin/Cdk site and gained without addition of any cyclin/Cdk site because it depends on a FOXM1c domain with no potential cyclin/Cdk site , namely on the interaction domain for the tumor suppressor RB , which binds to and represses FOXM1c . Positive_regulation CCND1 FOXM1 23333330 2747098 [CyclinD1/Cdk4] *activates* because cyclinD1/Cdk4 releases FOXM1c from its repression by RB through removal of RB from FOXM1c . Positive_regulation CCND1 FOXM1 23812424 2937896 directly *activates* transcription of [cyclin D1] and cyclin B1 , resulting in the enhancement of cell cycle progression and cell proliferation . Positive_regulation CCND1 FOXM1 24726291 2935722 More important , the depletion of levels in gastric cancer cells *led* to significant decreases in the NF-?B p65 subunit , [cyclin D1] , Hes-1 , VEGF , and EpCAM protein levels . Positive_regulation CCND1 FOXO1 19938874 2190508 Furthermore , a luciferase assay demonstrated that could *regulate* the expression of [Ccnd1] at the transcription level . Positive_regulation CCND1 FOXO1 21179458 2358286 The inhibition of PI3K/AKT pathway *induced* transcriptional activity resulting in induction of Bim , TRAIL , p27/KIP1 , DR4 and DR5 , and inhibition of [cyclin D1] . Positive_regulation CCND1 FOXO3 21179458 2358287 The inhibition of PI3K/AKT pathway *induced* transcriptional activity resulting in induction of Bim , TRAIL , p27/KIP1 , DR4 and DR5 , and inhibition of [cyclin D1] . Positive_regulation CCND1 FOXO4 21179458 2358288 The inhibition of PI3K/AKT pathway *induced* transcriptional activity resulting in induction of Bim , TRAIL , p27/KIP1 , DR4 and DR5 , and inhibition of [cyclin D1] . Positive_regulation CCND1 FOXO6 21179458 2358285 The inhibition of PI3K/AKT pathway *induced* transcriptional activity resulting in induction of Bim , TRAIL , p27/KIP1 , DR4 and DR5 , and inhibition of [cyclin D1] . Positive_regulation CCND1 FRS2 20709201 2330124 These results suggest that signaling by extracellular Pi is mediated by Pit-1 and , and *leads* to activation of the Raf/MEK/ERK pathway and increased expression of [cyclin D1] , which facilitates the proliferation of immature chondrocytes . Positive_regulation CCND1 FST 18804092 1976228 *induced* [cyclin D1] and the trefoil factors TFF1 and TFF2 in a gastric cancer cell line . Positive_regulation CCND1 FUT1 12588994 1059770 *regulates* accumulation of [cyclin D1] and cyclin D1-dependent protein kinase . Positive_regulation CCND1 GADD45A 18798263 1969441 Both carotenoids induced cell cycle arrest during G ( 1 ) phase by reducing the expression of [cyclin D1] , cyclin D2 , CDK4 and CDK6 , and *inducing* the expression of , and induced apoptosis by reducing the expression of Bcl-2 , XIAP , cIAP2 and survivin . Positive_regulation CCND1 GAL 18045963 1832929 In Y1 cells , AVP blocks [cyclin D1] expression , *induces* senescence associated beta-galactosidase ( ) and inhibits proliferation . Positive_regulation CCND1 GAL 18045963 1832933 In addition , ectopic expression of the dominant negative RhoAN19 mutant blocks RhoA activation , yielding Y1 cell sub-lines which are no longer susceptible to [cyclin D1] downregulation , *induction* , or proliferation inhibition by AVP . Positive_regulation CCND1 GALT 20538716 2308245 Furthermore , down-regulation of I expression *attenuates* E2F1 induced DNA synthesis and cell cycle progression as well as the expression of cell-cycle regulator [Cyclin D1] . Positive_regulation CCND1 GAST 11748587 889655 CCK ( B ) receptor *mediates* synergistic stimulation of DNA synthesis and [cyclin D1] , D3 , and E expression in Swiss 3T3 cells . Positive_regulation CCND1 GAST 17185632 1717327 Inducible cAMP early repressor suppresses *mediated* activation of [cyclin D1] and c-fos gene expression . Positive_regulation CCND1 GAST 17185632 1717335 Here we show that *induces* transcription of cell cycle gene [cyclin D1] and protooncogene c-fos in the neuroendocrine pancreatic cell line AR42J and that this gastrin response is inhibited by endogenous inducible cAMP early repressor (ICER) . Positive_regulation CCND1 GATA3 20154722 2248568 Silencing of *resulted* in reduced [Cyclin D1] promoter activity and reduced Cyclin D1 mRNA and protein levels . Positive_regulation CCND1 GDF15 22484283 2601600 MIC-1 induced expression of cyclins D1 and E was mediated by AP-1 and E2F-1 transcription factors , and among the AP-1 members , c-Jun and JunD appeared to participate in *dependent* transcription of the [cyclin D1] gene . Positive_regulation CCND1 GDF15 22484283 2601602 Additionally , the PI3K/Akt , JNK , and ERK pathways were found to mediate *induced* [cyclin D1] expression in HUVECs . Positive_regulation CCND1 GDF9 19366876 2081623 In contrast , SIS3 reversed the decrease in p15(INK4B) and p16(INK4A) but not the increase in [cyclin D(1)] and E *induced* by . Positive_regulation CCND1 GGNBP2 12522140 1063998 *induced* degradation of [cyclin D1] was also prevented by treatment with lithium chloride , an inhibitor of glycogen synthase kinase-3beta ( GSK-3beta ) , suggesting that DIF-3 induced cyclin D1 proteolysis through the activation of GSK-3beta . Positive_regulation CCND1 GGNBP2 17046823 1654494 We revealed that T286A , T288A , and T286A/T288A mutants were resistant to DIF-3 induced degradation compared with wild-type cyclin D1 , indicating that the phosphorylation of Thr ( 286 ) and Thr ( 288 ) were critical for [cyclin D1] degradation *induced* by . Positive_regulation CCND1 GGNBP2 17046823 1654495 Depletion of endogenous GSK-3beta and dual-specificity tyrosine phosphorylation regulated kinase 1B ( DYRK1B ) by RNA interference attenuated the *induced* [cyclin D1] phosphorylation and degradation . Positive_regulation CCND1 GGNBP2 17046823 1654498 These results suggest that *induces* degradation of [cyclin D1] through the GSK-3beta- and DYRK1B mediated threonine phosphorylation in HeLa cells . Positive_regulation CCND1 GHRH 12679459 1077186 ERK cascade blockade in GH-omas did not affect basal and GHRH stimulated GH release , whereas it totally prevented the 3-fold increase in [cyclin D1] protein expression *induced* by . Positive_regulation CCND1 GHRH 12679459 1077187 In conclusion , this study demonstrated that in pituitary adenomas the activation of GPCR by neurohormones caused a PKC dependent activation of ERK1/2 cascade that , at least in GH-omas , resulted to be involved in [cyclin D1] *induction* by . Positive_regulation CCND1 GJA1 24056538 2846442 We confirmed that Hsc70 directly binds to the C-terminus of Cx43 , whereas Hsc54 , a splice variant of Hsc70 , does not , that Cx43 competes with cyclin D1 for binding to Hsc70 , and that the nuclear accumulation of [cyclin D1] is *reduced* by overexpression of in a GJIC independent manner , which is restored by co-overexpression with Hsc70 . Positive_regulation CCND1 GLA 19292920 2051622 [Cyclin D1] protein expression was increased by 42 +/- 12 % in the *presence* of . Positive_regulation CCND1 GLB1 18045963 1832930 In Y1 cells , AVP blocks [cyclin D1] expression , *induces* senescence associated ( SAbeta-Gal ) and inhibits proliferation . Positive_regulation CCND1 GPR158 23451275 2749457 overexpression *upregulates* levels of the cell cycle regulator [cyclin D1] , but mutation of the NLS reverses this . Positive_regulation CCND1 GPS2 17591692 1779288 is *required* for full expression of the ERalpha target genes [cyclin D1] , BCL-2 , and progesterone receptor but not pS2 , and its depletion significantly attenuated estrogen dependent proliferation of MCF-7 cells . Positive_regulation CCND1 GPS2 18632669 1959968 Overexpression of and NCoR *attenuated* the transcription of beta-catenin-TCF4-specific reporter gene and of [CCND1] , an endogenous beta-catenin target gene . Positive_regulation CCND1 GPS2 21901538 2521948 We also found that when down regulation of p65 , the expression of [cyclin D1] and Bc1-2 decreased , and the expression of *increased* in vitro and vivo . Positive_regulation CCND1 GRAP2 10066798 593771 Optimal induction of [cyclin D1] by pp60 ( v-src ) *involved* the extracellular signal regulated kinase , , and c-Jun N-terminal kinase members of the mitogen activated protein kinase family . Positive_regulation CCND1 GRAP2 17308107 1699451 Indeed , chemical inhibition ( PD169316 ) and small interfering RNA directed against p38 *blocked* aspirin induced [cyclin D1] degradation , nucleolar translocation of RelA , and apoptosis . Positive_regulation CCND1 GRAP2 17483331 1739088 Furthermore , EGF- and heregulin induced [cyclin D1] expression is *dependent* on signaling and inhibited by Brk shRNA knockdown . Positive_regulation CCND1 GRAP2 21911485 2516045 Here , we show that both genetic and pharmacologic inhibition of in glioblastoma multiforme cells significantly *reduces* rapamycin induced IRES mediated translation initiation of [cyclin D1] and c-MYC , resulting in increased G ( 1 ) arrest in vitro and inhibition of tumor growth in xenografts . Positive_regulation CCND1 GRAP2 22054946 2503950 Further , Cf-PS treatment induced the translocation of ß-catenin , an effector of the Wnt signaling pathway , from the cytosol to the nucleus and *increased* the expression of [cyclinD1] and c-myc. Cf-PS also induced ERK1/2 phosphorylation , which is activated by mitogenic and proliferative stimuli such as growth factors , but the phosphorylation of JNK and was not enhanced . Positive_regulation CCND1 GRK5 22099983 2529546 Also , evidence revealed that the loss of activity *resulted* in decreased [cyclin D1] expression , Rb protein phosphorylation and E2F target gene expression involved in cell cycle control . Positive_regulation CCND1 GRM5 21723923 2471383 Our findings demonstrated that *promoted* the proliferation of human embryonic cortical NPCs and increased [cyclin D1] expression with the changes in phosphorylation of MAPKs signaling pathways in vitro , suggesting a novel mechanism for pharmacological study of treatment for ischemic brain injury and neurodegenerative disorders . Positive_regulation CCND1 GSK3B 10910956 715809 These findings suggest that overexpression of [cyclin D1] results from stabilization due to a lack of phosphorylation *mediated* by . Positive_regulation CCND1 GSK3B 11124803 758648 *dependent* phosphorylation of [cyclin D1] at Thr-286 promotes the nuclear-to-cytoplasmic redistribution of cyclin D1 during S phase of the cell cycle , but how phosphorylation regulates redistribution has not been resolved . Positive_regulation CCND1 GSK3B 12235165 1012353 Overexpression of an uninhibitable mutant *resulted* in partial inhibition of FGF-2 mediated [cyclin D1] induction . Positive_regulation CCND1 GSK3B 12526086 1028225 Since is *involved* in [cyclin D1] proteolysis in response to mitogenic stimulation , PLCgamma1 mediated GSK-3beta phosphorylation may function as a regulation of cyclin D1 accumulation in PLCgamma1 overexpressing cells . Positive_regulation CCND1 GSK3B 14612495 1163311 *dependent* phosphorylation of [cyclin D1] at a conserved COOH-terminal residue , Thr-286 , promotes CRM1 dependent cyclin D1 nuclear export at the G ( 1 ) -S boundary . Positive_regulation CCND1 GSK3B 15513923 1347720 *dependent* phosphorylation of [cyclin D1] at a conserved C-terminal residue , Thr-286 , promotes CRM1 dependent cyclin D1 nuclear export . Positive_regulation CCND1 GSK3B 16788573 1585777 Overexpressing constitutively active form of induced entry into the S phase , *increased* [cyclin D1] expression and facilitated the proliferation of ovarian cancer cells . Positive_regulation CCND1 GSK3B 17046823 1654496 Depletion of endogenous and dual-specificity tyrosine phosphorylation regulated kinase 1B ( DYRK1B ) by RNA interference *attenuated* the DIF-3 induced [cyclin D1] phosphorylation and degradation . Positive_regulation CCND1 GSK3B 18023328 1866877 *regulates* [cyclin D1] expression : a new target for chemotherapy . Positive_regulation CCND1 GSK3B 18474214 1944721 Advanced glycation end-product inhibited cell proliferation and protein expression of beta-catenin and [cyclin D1] are *dependent* on in LLC-PK1 cells . Positive_regulation CCND1 GSK3B 18809569 1987366 Double-strand break dependent [cyclin D1] degradation *requires* ATM and , which in turn mediate cyclin D1 phosphorylation . Positive_regulation CCND1 GSK3B 19196980 2039050 Paradoxically , the inhibitors lithium chloride and SB216763 selectively decreased the proliferation of human breast and colorectal cancer cell lines with oncogenic PIK3CA mutations and *led* to a decrease in the GSK3beta target gene [CYCLIN D1] . Positive_regulation CCND1 GSK3B 19882709 2293563 These findings suggest that GSK-3beta is a differentiation fate determinant , and shed new lights on the mechanism by which *regulates* [cyclin D1] degradation and cellular differentiation in gliomas . Positive_regulation CCND1 GSK3B 20439707 2262651 In C/EBPdelta knockout mouse embryo fibroblasts (MEF) Cdc27 levels were reduced , whereas [cyclin D1] levels were increased even in the *presence* of activated . Positive_regulation CCND1 GSK3B 9832503 551862 *regulates* [cyclin D1] proteolysis and subcellular localization . Positive_regulation CCND1 GTF2B 15226187 1301799 Our results suggest a model where bound at IgH regulatory sequences can *activate* the [cyclin D1] promoter by either long-range polymerase transfer or tracking . Positive_regulation CCND1 GTF2F1 15226187 1301800 Our results suggest a model where bound at IgH regulatory sequences can *activate* the [cyclin D1] promoter by either long-range polymerase transfer or tracking . Positive_regulation CCND1 GTF2F2 15226187 1301801 Our results suggest a model where bound at IgH regulatory sequences can *activate* the [cyclin D1] promoter by either long-range polymerase transfer or tracking . Positive_regulation CCND1 GUCY2D 19086036 2041976 Blocking c-Myc induction in HuH-7 cells prevented the mediated *increase* in p53 and [cyclin D1] expression and reduced apoptosis . Positive_regulation CCND1 GYS1 23632004 2838295 In primary culture VSMCs , sustained stimulation with tPA induced collagen type I upregulation and triggered sequential signaling events involving Akt , extracellular signal regulated kinases 1/2 ( ERK1/2 ) , phosphorylation , and [cyclin D1] *induction* . Positive_regulation CCND1 GYS2 23632004 2838296 In primary culture VSMCs , sustained stimulation with tPA induced collagen type I upregulation and triggered sequential signaling events involving Akt , extracellular signal regulated kinases 1/2 ( ERK1/2 ) , phosphorylation , and [cyclin D1] *induction* . Positive_regulation CCND1 H2AFX 19901524 2166080 Likewise , cyclin E , but not cyclin B1 and [cyclin D1] , also *induced* the focus formation , suggesting that these DNA lesions may be induced via aberrant DNA replication process . Positive_regulation CCND1 HBEGF 10544013 563917 also rapidly activated MAPK and *induced* [cyclin D1] in mid-G1 with kinetics similar to TGFalpha . Positive_regulation CCND1 HBEGF 17909029 1803535 RNA silencing indicated that PIKfyve is a mediator of *stimulated* EGFR nuclear trafficking , EGFR binding to the [cyclin D1] promoter , and cell cycle progression . Positive_regulation CCND1 HDAC1 21233448 2402669 Furthermore , inhibition *repressed* mitogen induced [cyclin D1] mRNA expression and cyclin D1 promoter activity . Positive_regulation CCND1 HDAC1 21465537 2448221 Inhibition of activity with trichostatin A (TSA) , *blocked* cell proliferation , decreased expression of [Cyclin D1] , a positive cell cycle regulator , and increased expression of p27 and p57 , two negative cell cycle regulators . Positive_regulation CCND1 HDAC2 21233448 2402670 Furthermore , inhibition *repressed* mitogen induced cyclin D1 mRNA expression and [cyclin D1] promoter activity . Positive_regulation CCND1 HDAC2 21465537 2448222 Inhibition of activity with trichostatin A (TSA) , *blocked* cell proliferation , decreased expression of [Cyclin D1] , a positive cell cycle regulator , and increased expression of p27 and p57 , two negative cell cycle regulators . Positive_regulation CCND1 HDAC3 17591692 1779289 is *required* for full expression of the ERalpha target genes [cyclin D1] , BCL-2 , and progesterone receptor but not pS2 , and its depletion significantly attenuated estrogen dependent proliferation of MCF-7 cells . Positive_regulation CCND1 HDAC3 18632669 1959969 Overexpression of SMRT and *attenuated* the transcription of beta-catenin-TCF4-specific reporter gene and of [CCND1] , an endogenous beta-catenin target gene . Positive_regulation CCND1 HDAC3 21901538 2521949 We also found that when down regulation of p65 , the expression of [cyclin D1] and Bc1-2 decreased , and the expression of *increased* in vitro and vivo . Positive_regulation CCND1 HEXIM1 18757415 1956553 *regulates* 17beta-estradiol/estrogen receptor-alpha mediated expression of [cyclin D1] in mammary cells via modulation of P-TEFb . Positive_regulation CCND1 HGF 11267961 797257 Epidermal growth factor (EGF) or *stimulated* increase of [cyclin D1] protein after 12 hours and increased DNA content after 3 days in culture . Positive_regulation CCND1 HGF 11850817 913059 We here report that can *induce* [cyclin D1] expression in mouse melanoma cells , and that this up-regulation is mediated in part by the activating transcription factor-2 ( ATF-2 ) . Positive_regulation CCND1 HGF 11850817 913092 However , transcriptional *up-regulation* of [cyclin D1] by was partially inhibited by the p38 kinase-specific inhibitor , and cyclin D1 protein induction was partially blocked by a dominant negative ATF-2 mutant . Positive_regulation CCND1 HGF 11984522 935672 Accordingly , we found that S-adenosylmethionine inhibits *induced* [cyclin D1] and D2 expression , activator protein 1 induction , and hepatocyte proliferation . Positive_regulation CCND1 HGF 15277494 1277213 Activation of both ERK and JNK/SAPK was necessary for the *stimulated* induction of [cyclin D1] , which in turn was necessary for the HGF induced proliferation of LECs . Positive_regulation CCND1 HGF 16831604 1587515 How SAM regulates hepatocyte growth is unclear , but because SAM blocks *induced* [cyclin D1] expression and DNA synthesis without affecting HGF induced extracellular signal regulated kinase phosphorylation , the mitogen activated protein kinase (MAPK) pathway is probably not the target . Positive_regulation CCND1 HGF 21769911 2494714 In HSP20 overexpressing cells , cell proliferation was retarded , and the activation of the mitogen activated protein kinases ( MAPKs ) signaling pathways , including the ERK and JNK , and AKT pathways , as well as [cyclin D1] accumulation *induced* by either transforming growth factor-a ( TGFa ) or , were significantly suppressed compared with the empty vector transfected cells ( control cells ) . Positive_regulation CCND1 HIF1A 18792914 2008958 Moreover , the soluble nickel induced [cyclin D1] degradation is dependent on its Thr286 residue and *requires* IKKalpha , but not , which are both reported to be involved in cyclin D1 down-regulation . Positive_regulation CCND1 HMGB1 20543468 2279437 Compared with the control group , at 10 , 50 , and 100 ng/mL obviously *increased* HepG2 cells proliferation , [cyclin D1] and PCNA protein and mRNA expression after the treatment for 24 h , respectively ( P < 0.05 ) . Positive_regulation CCND1 HMGB1 21069420 2419156 In vitro , recombined human induced RSC-364 cell proliferation , activated STAT1 phosphorylation , *increased* the expression of [cyclin D1] and CDK4 protein , and decreased the expression of p21 protein . Positive_regulation CCND1 HMGB1 22275109 2600104 Inhibition of by a specific short hairpin RNA vector *prevented* [cyclin D1/CDK4/p16] up-regulation and attenuated IFN-? induced MMC cell proliferation and PCNA ( proliferating cell nuclear antigen , PCNA ) expression . Positive_regulation CCND1 HNF1A 12951064 1137335 mediated *transactivation* of [cyclin D1] promoter is negatively regulated by thyroid hormone . Positive_regulation CCND1 HNF1A 20568120 2320372 Suppression of and CDX2 expression by small interfering RNA ( siRNA ) significantly *down-regulated* expressions of CDH17 and its downstream target [cyclin D1] and the viability of HCC cells in vitro . Positive_regulation CCND1 HRAS 10340949 616229 Finally , the synthetic MEK inhibitor PD98059 blocked *induced* [cyclin D1] promoter activity . Positive_regulation CCND1 HRAS 10531005 561994 By microinjecting anti-Ras antibody , we found that the induction of [cyclin D1] expression beginning in G2 phase was *dependent* on activity . Positive_regulation CCND1 HRAS 10531005 561997 *dependent* induction of [cyclin D1] expression beginning in G2 phase is critical for continuous cell cycle progression in NIH3T3 cells . Positive_regulation CCND1 HRAS 10611246 656157 Induction of [cyclin D1] by NeuT *involved* , Rac , Rho , extracellular signal regulated kinase , c-Jun N-terminal kinase , and p38 , but not phosphatidylinositol 3-kinase . Positive_regulation CCND1 HRAS 10681535 669399 We found that TPO stimulation or ( G12V ) expression *led* to up-regulation of [cyclin D1] , cyclin D2 , and cyclin D3 expression . Positive_regulation CCND1 HRAS 10698514 671844 As already reported , oncogenic expression was *sufficient* to induce [cyclin D1] and p21cip1 expression and their association with cdk4 . Positive_regulation CCND1 HRAS 10843991 721996 Using a pharmacological and a co-transfection approach , we found that , Raf-1 , phosphatidylinositol 3-kinase and also the catalytic activity of SHP-2 and its Src homology 2 domains are *required* for [cyclin D1] promoter/reporter gene activation by Ang II through the regulation of MAPK/ERK activity . Positive_regulation CCND1 HRAS 11159909 781452 Activation of and Erk *causes* induction of [cyclin D1-Cdk4] without increase of cyclin E or PCNA in ductal lesions . Positive_regulation CCND1 HRAS 11223027 787807 Thus , activity during G2 phase *induces* [cyclin D1] expression . Positive_regulation CCND1 HRAS 11278613 802709 LY-294002 blocked the *induced* expression of [cyclin D1] , cyclin dependent kinase (CDK) 2 , and increased the levels of p27 ( kip ) . Positive_regulation CCND1 HRAS 12082537 958577 In exponentially growing cells , oncogenic *had* no effect on proliferation rates , Erk phosphorylation , or the level of [cyclin D1] , and Ras-induction did not confer serum independent growth . Positive_regulation CCND1 HRAS 12082537 958589 in this setting , induction *prevented* full downregulation of [cyclin D1] and inactivation of Erk . Positive_regulation CCND1 HRAS 12140765 969461 Here , we demonstrate that oncogenic or constitutively active Her-2 cause *increased* proliferation and [cyclin D1] upregulation in fully polarized , mammary epithelial cells ( EpH4 ) , if cultivated as organotypic structures in three-dimensional collagen/matrigel matrices . Positive_regulation CCND1 HRAS 12202534 983083 The requirement for and the regulatory *role* of ERK2 in [cyclin D1] production and in cell proliferation suggest that the Ras/Raf/MEK/ERK pathway plays a key role in the control of RPE cell proliferation . Positive_regulation CCND1 HRAS 12386817 999799 To understand the mechanism of the *dependent* [cyclin D1] induction , cyclin D1 mRNA levels were determined by quantitative image analysis following fluorescent in situ hybridization . Positive_regulation CCND1 HRAS 12429909 1015092 These studies were designed to understand how could *induce* [cyclin D1] levels only during G2 phase . Positive_regulation CCND1 HRAS 12429909 1015098 This suggests that [cyclin D1] induction during G2 phase is not the *result* of activation specifically during this cell cycle period . Positive_regulation CCND1 HRAS 12505306 1026996 The hormone also causes a decrease of cyclin D1 gene transcription , and is able to antagonize the *activation* of the [cyclin D1] promoter by . Positive_regulation CCND1 HRAS 12648671 1070443 The decision to continue cell cycle progression takes place in G2 phase , when cellular *induces* the elevation of [cyclin D1] levels . Positive_regulation CCND1 HRAS 12794085 1120067 Although Ras , Raf , and MEK all increased expression of cyclin D1 on collagen film , only and Raf significantly *up-regulated* [cyclin D1] levels on collagen gel . Positive_regulation CCND1 HRAS 14657670 1188534 PAK is essential for *induced* upregulation of [cyclin D1] during the G1 to S transition . Positive_regulation CCND1 HRAS 14657670 1188544 In this report , using two distinct inhibitors specific for PAK1-3 ( CEP-1347 and WR-PAK18 ) , we present the first evidence indicating that the PIX/Rac/CDC42 dependent Ser/Thr kinases PAK1-3 , acting downstream of PI-3 kinase and upstream of the Raf/MEK/ERKs kinase cascade , is essential for *induced* upregulation of [cyclin D1] , but not downregulation of p27 . Positive_regulation CCND1 HRAS 15675969 1366391 Taken together , these results suggest that CWF inhibits the growth of dermal fibroblasts at least in part by decreasing the level of active , resulting in decreased *levels* of ppRb and [cyclin D1] . Positive_regulation CCND1 HRAS 15958613 1422837 Inhibition of active by farnesylthiosalicylic acid *led* to attenuation of the Raf-MEK-ERK and phosphoinositide 3-kinase-Akt-glycogen synthase-3 ( GSK-3 ) pathways , to reduction in [cyclin D1] , phospho-retinoblastoma , and E2F , and to increase in the cyclin dependent kinase inhibitor p27 and in retinoblastoma binding protein-1 , an inhibitor of E2F transcriptional activity . Positive_regulation CCND1 HRAS 18604165 1935596 However , more recent reports suggested that the commitment to cycle in response to serum occurs already in G ( 2 ) phase and requires the dependent *induction* of [cyclin D1] , which promotes following G ( 1 ) /S transition . Positive_regulation CCND1 HRAS 20717927 2345720 In MIA PaCa-2 cells in culture , LOX-PP attenuated the ERK and AKT activities and decreased the levels of the NF-?B p65 and RelB subunits and [cyclin D1] , which are *activated* by signaling . Positive_regulation CCND1 HRAS 20798689 2368246 ASPP2 suppresses *induced* small ubiquitin-like modifier (SUMO) modified nuclear [cyclin D1] and inhibits retinoblastoma protein ( Rb ) phosphorylation . Positive_regulation CCND1 HRAS 7559524 323567 Transforming mutants and c-Ets-2 *activate* the [cyclin D1] promoter through distinguishable regions . Positive_regulation CCND1 HRAS 7559524 323568 Site directed mutagenesis of AP-1-like sequences at -954 abolished *dependent* activation of [cyclin D1] expression . Positive_regulation CCND1 HRAS 7559524 323616 The *activation* of [cyclin D1] transcription by provides evidence for cross-talk between the p21ras and cell cycle regulatory pathways . Positive_regulation CCND1 HRAS 9199319 438899 Analysis of Cdk-cyclin complexes indicates that signaling is *required* both for induction of [cyclin D1] and for downregulation of the Cdk inhibitor p27KIP1 . Positive_regulation CCND1 HRAS 9407076 470823 Overexpression of dominant negative forms of or RhoA completely blocked PDGF induced p27 ( KIP1 ) degradation , but only dominant negative Ras *inhibited* [cyclin D1] protein expression . Positive_regulation CCND1 HRG 18355957 1912641 Down-regulation of EBP1 expression in MCF-7 cells by shRNA resulted in increased cell growth in *response* to and increased [cyclin D1] and ErbB2 expression . Positive_regulation CCND1 HSP90AA1 9207452 440859 There was a correlation between activity , cell cycle status by BrdU incorporation , and *induction* of phosphorylated retinoblastoma protein , CDC2 , CDK2 , [cyclin D1] , and cyclin A , but not cyclin E and B1 after 72 hours with multiple ( but not single ) cytokines . Positive_regulation CCND1 HSPA8 18537972 1952065 In conclusion , our studies suggest that STAT5 mediated activation of *induces* nuclear translocation and activation of the [CCND1/CDK4 complex] leading to increased proliferation of CML cells , deciphering a new pathway implicated in CML and supporting a potential role of chaperone inhibitors in the treatment of CML . Positive_regulation CCND1 HSPG2 18980246 1995234 and protein kinase C ( PKC ) *mediated* the L-leucine induced increases in [ 3H ] -thymidine incorporation and [cyclin D1/CDK4] and cyclin E/CDK2 expression , as U73122 ( a PLC inhibitor ) or bisindolylmaleimide I ( a PKC blocker ) inhibited these effects . Positive_regulation CCND1 ID1 17149750 1687040 Blockage of the NF-kappaB activity with pyrrolidine dithiocarbamate ( PDTC ) or enhancement of the NF-kappaB activity with p65 ( a subunit of NF-kappaB ) in OC1 significantly inhibited or increased , respectively , the cell proliferation and transcription of [cyclin D1] *induced* by . Positive_regulation CCND1 ID2 22835384 2670931 Furthermore , a mutated NF-?B binding site in the cyclin D1 promoter fully abrogated the *induced* transcription of [cyclin D1] . Positive_regulation CCND1 IFI27 11593401 869819 We addressed whether down regulation was *required* to activate [cyclin D1/CDK4/6] or cyclin E/CDK2 by engineering cells with inducible p27 . Positive_regulation CCND1 IFI27 18710949 1968226 Thus , while PKB dependent p27 phosphorylation appears to increase cyclin D1-Cdk4-p27 assembly or stabilize these complexes in vitro , [cyclin D1-Cdk4-p27] activation *requires* the tyrosine phosphorylation of . Positive_regulation CCND1 IFI27 19304953 2064352 Moreover , we demonstrated that the upregulation of AEG-1 could reduce the expression of ( Kip1 ) and *induce* the expression of [cyclin D1] through the AKT/FOXO3a pathway . Positive_regulation CCND1 IFI27 19954644 2172449 Western blot results showed that the Akt phosphorylation and [cyclin D1] expression was significantly decreased ( P < 0.01 ) , and the expression of ( KIP1 ) and p21 ( WAF1/CIPI ) *increased* . Positive_regulation CCND1 IFI27 21312237 2398653 WIN 55,212-2 also upregulated phospho-ERK1/2 , *induced* and Cip1/WAF1/p21 expression , decreased [cyclin D1] and cyclin E expression , decreased Cdk 2 , Cdk 4 , and Cdk 6 expression levels , and decreased phospho-Rb and E2F-1 expression . Positive_regulation CCND1 IFI27 23268392 2709625 Treatment of the LPS challenged cells with QFTLR and benazepril both *resulted* in significantly attenuated expressions of [cyclin D1] , CDK2 , and P21 and obvious increase of expression ( P < 0.05 or P < 0.01 ) , but QFTLR produced stronger effects than benazepril in regulating of cyclinD1 , P21 and P27 protein expressions ( P < 0.05 or P < 0.01 ) . Positive_regulation CCND1 IFI44 8702807 376061 We found that inhibition of the ( MAPK ) signaling by expression of dominant negative forms of either mitogen activated protein kinase kinase 1 ( MKK1 ) or p44 ( MAPK ) , or by expression of the MAP kinase phosphatase , MKP-1 , strongly *inhibited* expression of a reporter gene driven by the human cyclin D1 promoter as well as the endogenous [cyclin D1] protein . Positive_regulation CCND1 IFNG 12588705 1084954 Mitogen induced expression of cell cycle regulator [cyclin D1] was *increased* by , whereas no effect was observed on degradation of p27 ( Kip1 ) . Positive_regulation CCND1 IGF1 11787050 901336 Treatment of PI3K inhibitor LY294002 and the MAP kinase inhibitor PD098059 , but not p38 inhibitor SB203580 , effectively blocks *induced* upregulation of Pin1 , [cyclin D1] and RB phosphorylation . Positive_regulation CCND1 IGF1 12364325 1019157 *triggers* nuclear accumulation of [cyclin D1] in MCF-7S breast cancer cells . Positive_regulation CCND1 IGF1 12364325 1019158 Stimulation of the breast cancer derived MCF-7S cell line with ( IGF-I ; 20 ng/ml ) *leads* to enhanced expression of [cyclin D1] , hyperphosphorylation of pRb , DNA synthesis , and cell division . Positive_regulation CCND1 IGF1 12364325 1019159 We have previously shown that the synergistic action of E ( 2 ) and IGF-I emanates from the ability of both hormones to induce cyclin D1 expression and that action is *required* to induce activity of the [cyclin D1-CDK4] complex , which triggers cell cycle progression . Positive_regulation CCND1 IGF1 12364325 1019161 This notion was confirmed by overexpression of constitutively active GSK3beta , which blocks *induced* nuclear accumulation of [cyclin D1] as well as S phase transition . Positive_regulation CCND1 IGF1 12554765 1071536 Second , whereas PR and cyclin D1 are both ER up-regulated , *increased* [cyclin D1] levels while decreasing PR levels . Positive_regulation CCND1 IGF1 12867429 1141876 This latter result is explained by a delay in G1 to S cell cycle progression due partly to a reduction in the activation of some components of cell cycle including the induction of [cyclin D1] expression in *response* to . Positive_regulation CCND1 IGF1 1379514 193036 by itself does not *induce* [cyclin D1] expression , and an antisense oligodeoxynucleotide to the insulin-like growth factor 1 receptor RNA does not affect the growth regulated levels of cyclin D1 mRNA . Positive_regulation CCND1 IGF1 15033176 1223348 and FGF-2 coordinately *enhance* [cyclin D1] and cyclin E-cdk2 association and activity to promote G1 progression in oligodendrocyte progenitor cells . Positive_regulation CCND1 IGF1 15033176 1223350 *enhanced* FGF-2 induction of [cyclin D1] , activation of G ( 1 ) cyclin-cyclin dependent kinase (cdk) complexes , and hyperphosphorylation of retinoblastoma protein ( pRb ) . Positive_regulation CCND1 IGF1 15187095 1280688 This effect was also associated with a reduction in *induced* [cyclin D1] expression . Positive_regulation CCND1 IGF1 15580291 1368705 Ras- and Rac-GTPases were found to be upstream activators of cyclin D1 expression , whereas protein kinase B/AKT and nuclear factor kappa B (NFkappaB) could be established as downstream mediators of [cyclin D1] transcription in *response* to endogenously released in these cells . Positive_regulation CCND1 IGF1 15607540 1356949 Therefore , estrogen and differentially *regulate* c-Myc and [cyclin D1] to cooperatively stimulate breast cancer cell proliferation . Positive_regulation CCND1 IGF1 16326831 1488416 The results showed that *dependent* phosphorylation of Akt and mitogen activated protein kinase , induction of G ( 1 ) -S-phase progression and enhanced expression of [cyclin D1] and cyclin E were dependent on ERalpha . Positive_regulation CCND1 IGF1 16326831 1488450 Moreover , these same IGF-I induced responses were also inhibited by the antiestrogen ICI 182780 and this was in contrast to a previous report suggesting that ICI 182780 did not affect *dependent* activation of PI3-K or induction of [cyclin D1] expression . Positive_regulation CCND1 IGF1 16397250 1506272 At doses that inhibited proliferation , the compound also caused a G0-G1 arrest and prevented nuclear accumulation of [cyclin D1] in *response* to LR3 . Positive_regulation CCND1 IGF1 16408277 1540196 Surprisingly , *activates* the expression of both [cyclin D1] and cell-cycle arrest factor , p21Cip1 parallely . Positive_regulation CCND1 IGF1 16408277 1540197 Pharmacological inhibition of calcineurin by cyclosporin A blocks *induced* [cyclin D1] and p21Cip1expression significantly ( P < 0.05 ) . Positive_regulation CCND1 IGF1 16697771 1560430 PDGF and also *increased* the levels of [cyclin D1] and phospho-glycogen synthase kinase-3beta . Positive_regulation CCND1 IGF1 17166846 1694612 potentiated the effects of E2 on ERE but not to AP-1 and *increased* E2-dependent pS2 , but not [cyclin D1] , mRNA expression . Positive_regulation CCND1 IGF1 17487372 1739268 and *increased* at 24 h . [Cyclin D1] and Cox-2 levels increased with leptin treatment . Positive_regulation CCND1 IGF1 17508424 1761884 Synergistic *induction* of [cyclin D1] in oligodendrocyte progenitor cells by and FGF-2 requires differential stimulation of multiple signaling pathways . Positive_regulation CCND1 IGF1 17508424 1761886 In contrast , blocking the PI3-Kinase pathway results in loss of synergistic *induction* of [cyclin D1] protein levels . Positive_regulation CCND1 IGF1 17508424 1761887 Moreover , the presence of significantly *enhances* nuclear localization of [cyclin D1] , which also requires PI3K signaling . Positive_regulation CCND1 IGF1 17508424 1761893 Thus , we provide a model for cyclin D1 coordinate regulation where FGF-2 stimulation of the MAPK pathway promotes cyclin D1 mRNA expression while activation of the PI3K pathway inhibits proteasome degradation of cyclin D1 and *enhances* nuclear localization of [cyclin D1] . Positive_regulation CCND1 IGF1 17982240 1821099 The expressions of genes for bone morphogenetic protein 6 , the glucagon receptor , and [cyclin D1] were *increased* by both TSH and ; Positive_regulation CCND1 IGF1 18403485 1925957 We found that cAMP pretreatment enhanced *dependent* increases in [cyclin D1] , due to synergistic increases in mRNA and elevation of translation rates . Positive_regulation CCND1 IGF1 18403485 1925961 In contrast , dependent PI 3-kinase activation was *required* for the increase in [cyclin D1] mRNA levels and degradation of p27 ( Kip1 ) . Positive_regulation CCND1 IGF1 18505926 1917960 Characterization of a novel primary mammary tumor cell line reveals that [cyclin D1] is *regulated* by the type I receptor . Positive_regulation CCND1 IGF1 19158303 2027257 *induced* rapid increases in [cyclin D1] and D3 protein levels at 4 h and cyclin E at 8 h . Positive_regulation CCND1 IGF1 19165858 2048448 Cell cycle progression and colony formation were affected in the presence of h7C10 probably because of the inhibition of *induced* [cyclin D1] and E expression . Positive_regulation CCND1 IGF1 19581924 2129288 We found previously that in intestinal cells , insulin or *stimulates* c-Myc and [cyclin D1] protein expression through both Akt dependent and Akt independent mechanisms . Positive_regulation CCND1 IGF1 19865540 2156733 It is presumed that estrogen and *regulate* c-Myc and [cyclin D1] during breast cancer cell proliferation . Positive_regulation CCND1 IGF1 21287577 2398286 Furthermore , we found that exogenous could not *promote* cell proliferation and [cyclin D1] expression in PSMCs subjected to shRNA mediated knockdown of ERa . Positive_regulation CCND1 IGF1 21315112 2414934 Regulation of *dependent* [cyclin D1] and E expression by hEag1 channels in MCF-7 cells : the critical role of hEag1 channels in G1 phase progression . Positive_regulation CCND1 IGF1 21315112 2414935 As expected , *increased* [cyclin D1] and E expression of MCF-7 cells in a cyclic manner , whereas the increase of CDK4 and 2 levels was sustained . Positive_regulation CCND1 IGF1 21315112 2414937 This study is the first to demonstrate that K ( + ) channels such as hEag1 are directly involved in the *induced* up-regulation of [cyclin D1] and E expression in MCF-7 cells . Positive_regulation CCND1 IGF1 21549192 2453843 However , stable transfection of a mutant GSK3ß ( S9A ) or a dominant negative K-CREB in TR-iBRB2 prevents *induced* fibronectin and [cyclin D1] expression . Positive_regulation CCND1 IGF1 23278864 2865463 Thus , *up-regulated* [cyclin D1] expression and accelerated G1 -phase progression in the cell cycle through Ras/Raf/MEK/ERK pathway in rumen epithelium of goats . Positive_regulation CCND1 IGF1 23447091 2809698 Transient transfection of a reporter driven by the rat cyclin D1 promoter showed that *stimulates* [cyclin D1] promoter activity . Positive_regulation CCND1 IGF1 23447091 2809699 Furthermore , 5'-end deletions and mutation analysis of this promoter revealed that a cAMP response element ( CRE ) within -174 base pair ( bp ) upstream of the transcription start site is crucial to the *induced* increase in [cyclin D1] transcription . Positive_regulation CCND1 IGF1 23447091 2809716 Taken together , our data indicate that *upregulates* [cyclin D1] transcription partially by inducing CREB phosphorylation through the ERK-MAP kinase pathway , and thus increasing its recruitment to the cyclin D1 promoter . Positive_regulation CCND1 IGF1 23504816 2772040 In this study , a robust [cyclin D1] expression was *observed* following stimulation in SY5Y cells as well as neurospheres . Positive_regulation CCND1 IGF1 23504816 2772045 Together , these findings shed new light on the mechanism of *mediated* upregulation of [cyclin D1] expression in neural cell lines as well as in neural stem cells via the JAK/STAT5 signaling cascade . Positive_regulation CCND1 IGF1 8800097 382014 Since nutritional deprivation is accompanied by lower levels of circulating insulin-like growth factor-I (IGF-I) , we determined whether directly *stimulated* the [cyclin D1] promoter . Positive_regulation CCND1 IGF1 8800097 382015 *stimulated* [cyclin D1] promoter activity 4- to 6-fold at 6 hours ( h ) . Positive_regulation CCND1 IGF1 9281369 451450 Cyclin E- and A-associated histone H1 kinase activity and [cyclin D1-associated] retinoblastoma protein associated kinase activity also increased , but cyclin B kinase activity was not *enhanced* by . Positive_regulation CCND1 IGF1R 18403642 1893869 Moreover , prolactin increased [cyclin D1] in the *presence* of the neutralizing antibody alphaIR3 . Positive_regulation CCND1 IGF2 17487372 1739269 and *increased* at 24 h . [Cyclin D1] and Cox-2 levels increased with leptin treatment . Positive_regulation CCND1 IGF2 23447091 2809700 Furthermore , 5'-end deletions and mutation analysis of this promoter revealed that a cAMP response element ( CRE ) within -174 base pair ( bp ) upstream of the transcription start site is crucial to the *induced* increase in [cyclin D1] transcription . Positive_regulation CCND1 IGF2 24380854 2906717 Collectively , our findings have revealed a new regulatory mechanism by which induction of AHR *promotes* the expression of [CCND1] and the proliferation of MCF-7 cells . Positive_regulation CCND1 IGH 2426362 61726 We therefore evaluated the *role* of two possible region linked gene products in [BCL1] growth inhibition ; Positive_regulation CCND1 IL10 24022823 2873824 Furthermore , the blocking of BMP signaling attenuated the mediated *induction* of [cyclin D1] and RUNX-2 in primary chondrocytes and suppressed Alcian blue and alkaline phosphatase staining in mesenchymal cell micromass cultures . Positive_regulation CCND1 IL1B 20548028 2284930 In the *presence* of , [cyclin D1] is phosphorylated and degraded , leading to inhibition of cell proliferation . Positive_regulation CCND1 IL3 10064602 593446 Both dn-STAT5 and dn-ras suppressed *induced* [cyclin D1] promoter activities in F-36P-mpl cells . Positive_regulation CCND1 IL5 7756840 307523 Recombinant human IL-5 prepared by this procedure bound to the high-affinity IL-5 receptor present on an eosinophilic leukemia cell line and elicited a proliferative response in the *dependent* murine B-cell line [BCL1] . Positive_regulation CCND1 IL6 12730884 1086817 Leptin replacement corrected these defects in ob/ob mice by restoring TNF and release and *inducing* [cyclin D1] . Positive_regulation CCND1 IL6 16520748 1555083 Furthermore , Mag suppressed *induced* promoter activity of [cyclin D1] and monocyte chemotactic protein (MCP)-1 for which STAT3 activation plays a role . Positive_regulation CCND1 IL6 17322172 1719824 also *induced* [cyclin D1] expression in a time- and gp130/STAT-3 dependent manner in VSMCs . Positive_regulation CCND1 IL6 20332458 2230777 CADPE significantly inhibited IL-6 induced signal transducer and activator of transcription 3 ( STAT3 ) activity in the Huh7 HCC cell line and attenuated *induced* [cyclin D1] transcription . Positive_regulation CCND1 IL6ST 21847632 2524262 We found that , in lung cancer cell lines and in nude mice , Interleukin-7/Interleukin-7 receptor increased the expression of cyclin D1 and phosphorylation of c-Fos/c-Jun , *induce* c-Fos and c-Jun formation , and enhanced c-Fos/c-Jun DNA binding activity to regulate [cyclin D1] . Positive_regulation CCND1 IL7 17704792 1806042 Of the BALB/c mice that received spleen cells from F ( 1 ) mice treated with IL-7 following transplantation of C57BL/6 spleen cells sensitized with irradiated [BCL(1)] in the *presence* of , only 29 % developed leukemia , as compared to 79 % in the control group ( P < 0.05 ) . Positive_regulation CCND1 IL7 21847632 2524253 Using Western blot , reverse transcriptase-PCR , Co-Immunoprecipitation , and Chromatin Immunoprecipitation , we investigated how *regulated* [cyclin D1] in vitro and in nude mice . Positive_regulation CCND1 IL7 21847632 2524263 We found that , in lung cancer cell lines and in nude mice , receptor *increased* the expression of [cyclin D1] and phosphorylation of c-Fos/c-Jun , induce c-Fos and c-Jun heterodimer formation , and enhanced c-Fos/c-Jun DNA binding activity to regulate cyclin D1 . Positive_regulation CCND1 IL7 21847632 2524296 Taken together , our results provided evidence that receptor *induced* [cyclin D1] up-regulation via c-Fos/c-Jun pathway to promote proliferation of cells in lung cancer . Positive_regulation CCND1 IL7R 21847632 2524264 We found that , in lung cancer cell lines and in nude mice , *increased* the expression of [cyclin D1] and phosphorylation of c-Fos/c-Jun , induce c-Fos and c-Jun heterodimer formation , and enhanced c-Fos/c-Jun DNA binding activity to regulate cyclin D1 . Positive_regulation CCND1 IL7R 21847632 2524297 Taken together , our results provided evidence that *induced* [cyclin D1] up-regulation via c-Fos/c-Jun pathway to promote proliferation of cells in lung cancer . Positive_regulation CCND1 IL8 17606477 1768503 Using PC3 and DU145 cell lines , we sought to determine whether signaling *regulated* [cyclin D1] expression in androgen independent prostate cancer ( AIPC ) cells and to characterize the signaling pathways underpinning this response and that of IL-8 promoted proliferation . Positive_regulation CCND1 IL8 17606477 1768505 Administration of recombinant human IL-8 induced a rapid , time dependent increase in cyclin D1 expression in AIPC cells , a response attenuated by the translation inhibitor cycloheximide but not by the RNA synthesis inhibitor , actinomycin D. Suppression of endogenous signaling using neutralizing antibodies to IL-8 or its receptors also *attenuated* basal [cyclin D1] expression in AIPC cells . Positive_regulation CCND1 IL8 17606477 1768510 Our results indicate that signaling ( a ) *regulates* [cyclin D1] expression at the level of translation , ( b ) regulates the activation of proteins associated with the translation of capped and 5'-oligopyrimidine tract transcripts , and ( c ) activates signal transduction pathways underpinning AIPC cell proliferation . Positive_regulation CCND1 ILK 19541809 2128737 Pharmacologic inhibition of with small-molecule inhibitor QLT-0267 abolished TGF-beta1 induced phosphorylation of Akt and glycogen synthase kinase-3beta , *suppressed* [cyclin D1] expression , and largely restored the expression of E-cadherin and zonula occludens 1 . Positive_regulation CCND1 ILK 9153256 431286 overexpression *results* in increased expression of [cyclin D1] , activation of Cdk4 and cyclin E-associated kinases , and hyperphosphorylation of the retinoblastoma protein . Positive_regulation CCND1 ILKAP 23329845 2747067 We also found that nuclear interacts with ribosomal protein S6 kinase-2 (RSK2) and *induces* apoptosis by inhibiting RSK2 activity and down regulating the expression level of the RSK2 downstream substrate [cyclin D1] . Positive_regulation CCND1 ING4 18399550 1893739 Overexpression of can induce growth inhibition in A549 cells both in vitro and in vivo , and also *induce* up-regulation of p27 , down-regulation of [cyclinD1] , SKP2 , and Cox2 , and inactivation of the Wnt-1/beta-catenin pathway . Positive_regulation CCND1 ING4 19430401 2077848 Overexpression of could induce growth suppression and apoptosis enhancement in M14 cells , and also *induce* the upregulation of p27 , Bax and Cyt-c , and the downregulation of [cyclinD1] , SKP2 , Bcl-2 , and caspase-3 . Positive_regulation CCND1 INS 11557838 861446 Removing from cultures *resulted* in a reduction in differentially elevated levels of [cyclin D1] . Positive_regulation CCND1 INS 11557838 861447 The elevated levels of [cyclin D1] expression we observed in mature adipocytes *depend* on . Positive_regulation CCND1 INS 15607540 1356948 These studies demonstrated that estrogen significantly increased both c-Myc and cyclin D1 protein , while predominantly *increased* [cyclin D1] levels . Positive_regulation CCND1 INS 15607540 1356950 Therefore , estrogen and differentially *regulate* c-Myc and [cyclin D1] to cooperatively stimulate breast cancer cell proliferation . Positive_regulation CCND1 INS 19581924 2129289 We found previously that in intestinal cells , or insulin-like growth factor-1 *stimulates* c-Myc and [cyclin D1] protein expression through both Akt dependent and Akt independent mechanisms . Positive_regulation CCND1 INS 19581924 2129292 Significantly , shRNA ( small hairpin RNA ) -mediated PAK-1 knockdown attenuated both basal and *stimulated* c-Myc and [cyclin D1] expression , associated with a marked reduction in extracellular signal regulated kinase activation and beta-cat phosphorylation at Ser675 . Positive_regulation CCND1 INS 19865540 2156734 It is presumed that estrogen and *regulate* c-Myc and [cyclin D1] during breast cancer cell proliferation . Positive_regulation CCND1 INS 24870244 2945652 Here we report that in mice *activates* [cyclin D1-cyclin] dependent kinase 4 (Cdk4) , which , in turn , increases GCN5 acetyltransferase activity and suppresses hepatic glucose production independently of cell cycle progression . Positive_regulation CCND1 INS 24870244 2945654 ( glycogen synthase kinase 3-beta ) signalling *induces* [cyclin D1] protein stability by sequestering cyclin D1 in the nucleus . Positive_regulation CCND1 INS 9458362 484602 Retinoic acid suppresses *induced* cell growth and [cyclin D1] gene expression in human breast cancer cells . Positive_regulation CCND1 INS 9458362 484603 We examined the effects of all-trans retinoic acid ( RA ) on the *induced* cell growth , cell cycle progression and [cyclin D1] gene expression in breast cancer cells . Positive_regulation CCND1 IRS1 17332342 1707481 The increased transformed phenotype is characterized by occupancy of the rDNA and cyclin D1 promoters by and the *activation* of the [cyclin D1] , c-myc , and rDNA promoters . Positive_regulation CCND1 IRS1 17700539 1848731 Transcriptional *activation* of c-myc and [cyclin D1] promoters by nuclear does not occur with a mutant , inactive IRS-1 protein ( deletion of the phosphotyrosine binding domain , PTB ) and does not require PI3-kinase activity . Positive_regulation CCND1 ISL1 21829621 2468188 Further investigation shows that *activated* both c-Myc and [CyclinD1] transcription through direct binding on their promoters . Positive_regulation CCND1 JAG1 19915977 2287047 We show that down-regulation *reduces* direct binding of Notch to the [cyclin D1] promoter , reduced cyclin D1 expression and inhibition of cell cycle progression through the cyclin D1-dependant G1/S checkpoint . Positive_regulation CCND1 JAK1 14580692 1156982 A inhibitor , tyrphostin AG490 , markedly *inhibited* Stat3 activation and expression of [cyclin D1] , bcl-xL and vascular endothelial growth factor mRNAs estimated by RT-PCR , as followed by growth arrest ( 6.3-21.3 % vs controls ; Positive_regulation CCND1 JAK1 23300886 2712461 Pharmacological inhibition of , PI3K/Akt or MEK/ERK signaling by AG490 , Wortmannin or U0126 , respectively , *reduced* leptin induced [cyclin D1] expression and NP cell proliferation . Positive_regulation CCND1 JAK2 14580692 1156983 A inhibitor , tyrphostin AG490 , markedly *inhibited* Stat3 activation and expression of [cyclin D1] , bcl-xL and vascular endothelial growth factor mRNAs estimated by RT-PCR , as followed by growth arrest ( 6.3-21.3 % vs controls ; Positive_regulation CCND1 JAK2 17519353 1772908 The is *required* for expression and nuclear accumulation of [cyclin D1] in proliferating mammary epithelial cells . Positive_regulation CCND1 JAK2 23300886 2712462 Pharmacological inhibition of , PI3K/Akt or MEK/ERK signaling by AG490 , Wortmannin or U0126 , respectively , *reduced* leptin induced [cyclin D1] expression and NP cell proliferation . Positive_regulation CCND1 JAK3 14580692 1156984 A inhibitor , tyrphostin AG490 , markedly *inhibited* Stat3 activation and expression of [cyclin D1] , bcl-xL and vascular endothelial growth factor mRNAs estimated by RT-PCR , as followed by growth arrest ( 6.3-21.3 % vs controls ; Positive_regulation CCND1 JAK3 23300886 2712463 Pharmacological inhibition of , PI3K/Akt or MEK/ERK signaling by AG490 , Wortmannin or U0126 , respectively , *reduced* leptin induced [cyclin D1] expression and NP cell proliferation . Positive_regulation CCND1 JUN 10340380 616152 This suggests that both early and late gene expression is regulated by the same Gi-mediated , MEK dependent MAPK signalling pathway but that expression of late AP-1 genes and [cyclin D1] *requires* that this pathway be persistently activated . Positive_regulation CCND1 JUN 10500157 648047 Both and ATF-2 *transactivated* the [cyclin D1] promoter in transient transfection experiments , and a clear additional increase was detected when ER was cotransfected with either c-Jun or with c-Jun and ATF-2 but not with ATF-2 alone . Positive_regulation CCND1 JUN 10500157 648052 To interpret these results , we propose a mechanism in which heterodimers bind to the CRE-D1 element and *mediate* the activation of [cyclin D1] promoter by the ER . Positive_regulation CCND1 JUN 10567390 567680 *Activation* of the [cyclin D1] gene by the E1A associated protein p300 through inhibits cellular apoptosis . Positive_regulation CCND1 JUN 11410592 843020 These results contrasted to a recent report showing that induction of [cyclin D1] by E2 in ER-positive MCF-7 and HeLa cells was *due* to up-regulation of c-jun and subsequent interaction of with the CRE . Positive_regulation CCND1 JUN 11984522 935673 Accordingly , we found that S-adenosylmethionine inhibits hepatocyte growth factor induced [cyclin D1] and D2 expression , *induction* , and hepatocyte proliferation . Positive_regulation CCND1 JUN 12654005 1072964 In lung , an increase in the expression of produced a significant *increase* in [cyclin D1] expression . Positive_regulation CCND1 JUN 15467760 1335229 Estrogen induced proliferation of normal endometrial glandular cells is initiated by transcriptional *activation* of [cyclin D1] via binding of to an AP-1 sequence . Positive_regulation CCND1 JUN 15467760 1335230 These findings suggest that E2-induced proliferation of normal endometrial glandular cells is initiated by transcriptional *activation* of [cyclin D1] via binding of to the AP-1 sequences . Positive_regulation CCND1 JUN 15574422 1368399 is *required* for activation of the [cyclin D1] promoter . Positive_regulation CCND1 JUN 16248432 1471667 B heterodimers induced by LMP1 could up *regulate* [cyclin D1] promoter activity and expression . Positive_regulation CCND1 JUN 16987002 1617631 In mouse lung epithelial cells that express Nox1 , Nox2 , Nox4 , p22(phox) , p47(phox) , p67(phox) , and Noxo1 , overexpression of Nox1 delayed cell cycle withdrawal by maintaining *dependent* expression of [cyclin D1] in low serum conditions . Positive_regulation CCND1 JUN 17278098 1725715 BRCA1-IRIS alone or in complex with steroid receptor co-activators was *targeted* to the [cyclin D1] promoter pre bound by the and activated its transcription , which could explain the co-overexpression of BRCA1-IRIS and Cyclin D1 in breast cancer cells coupled with their increased proliferation . Positive_regulation CCND1 JUN 19059425 2029952 Collectively , our results demonstrate that *mediated* [cyclin D1] expression is at least one of the key events implicated in cell transformation upon low dose arsenite exposure . Positive_regulation CCND1 JUN 19080374 2003313 The chemical inhibitor of , SP600125 , could *prevent* both [cyclin D1] and CDK4 protein expression level decrease . Positive_regulation CCND1 JUN 19519318 2092828 The inhibition of JNKs or by chemical or genetic inhibitors *blocks* the [cyclin D1] induction mediated by arsenite . Positive_regulation CCND1 JUN 21135252 2377989 *regulates* [cyclin D1] and c-MYC transcription in an AKT dependent manner in response to mTOR inhibition : role of AIP4/Itch mediated JUNB degradation . Positive_regulation CCND1 JUN 21726611 2471469 *Up-regulation* of [cyclin D1] by is involved in tumorigenesis of human embryo lung fibroblast cells induced by a low concentration of arsenite . Positive_regulation CCND1 JUN 21847632 2524265 We found that , in lung cancer cell lines and in nude mice , Interleukin-7/Interleukin-7 receptor increased the expression of cyclin D1 and phosphorylation of c-Fos/c-Jun , *induce* c-Fos and heterodimer formation , and enhanced c-Fos/c-Jun DNA binding activity to regulate [cyclin D1] . Positive_regulation CCND1 JUN 22002117 2513200 This study demonstrated that down-regulation of the Twist gene suppressed the proliferation of MKN45 gastric cancer cells by negatively regulating the activity resulting in the [cyclin D1] mRNA *level* decreasing . Positive_regulation CCND1 JUN 7559524 323570 The AP-1-like sequences were also required for *activation* of the [cyclin D1] promoter by . Positive_regulation CCND1 JUNB 10790372 689094 Since represses and c-Jun *activates* the [cyclin D1] promoter , these modifications of AP-1 activity during the M-G(1) transition could provide an impetus for G ( 1 ) progression by a temporal increase in cyclin D1 transcription . Positive_regulation CCND1 JUNB 16248432 1471668 heterodimers induced by LMP1 could up *regulate* [cyclin D1] promoter activity and expression . Positive_regulation CCND1 JUNB 21135252 2378014 Forced overexpression of or a conditionally active JunB-ER allele *repressed* [cyclin D1] and c-MYC promoter activity in quiescent AKT containing cells following rapamycin exposure . Positive_regulation CCND1 KAT2B 23543735 2788896 Our reporter assays indicated that the expression of *enhances* the activities of the E2F1 , [cyclin D1] , and cyclin E1 promoters . Positive_regulation CCND1 KAT5 23108396 2833346 Depletion of *prevented* [CCND1] activation . Positive_regulation CCND1 KAT7 18399550 1893738 Overexpression of can induce growth inhibition in A549 cells both in vitro and in vivo , and also *induce* up-regulation of p27 , down-regulation of [cyclinD1] , SKP2 , and Cox2 , and inactivation of the Wnt-1/beta-catenin pathway . Positive_regulation CCND1 KAT7 19430401 2077847 Overexpression of could induce growth suppression and apoptosis enhancement in M14 cells , and also *induce* the upregulation of p27 , Bax and Cyt-c , and the downregulation of [cyclinD1] , SKP2 , Bcl-2 , and caspase-3 . Positive_regulation CCND1 KCNK2 21949155 2525400 We developed an MLE-12 cell line deficient in Trek-1 expression using shRNA and found that deficiency *resulted* in increased cell proliferation and upregulation of PCNA but not [Cyclin D1] . Positive_regulation CCND1 KHDRBS1 16568089 1598086 SUMO modification of *enhances* its ability to repress [cyclin D1] expression and inhibits its ability to induce apoptosis . Positive_regulation CCND1 KHDRBS1 20028857 2192176 Our results identify Sam68 as the first splicing factor to affect CCND1 alternative splicing in prostate cancer cells , and suggest that increased levels of may *stimulate* [cyclin D1b] expression in human prostate cancers . Positive_regulation CCND1 KHDRBS1 9013542 411638 Transfected inhibits serum *induced* DNA synthesis and [cyclin D1] expression . Positive_regulation CCND1 KIT 17545544 1751965 Sorafenib blocked receptor autophosphorylation and signaling of and PDGFRbeta gatekeeper mutants in intact cells as well as *activation* of AP1-responsive and [cyclin D1] gene promoters , respectively . Positive_regulation CCND1 KLF5 14726538 1219906 Consistent with this role , we demonstrate that expression of in non transformed intestinal epithelial cells ( ileal IEC-18 and Immorto-Min Colon Epithelial ( IMCE ) cells ) *enhances* colony formation , [cyclin D1] transcription , and cell growth . Positive_regulation CCND1 KLF5 15077182 1237607 Lastly , *activates* expression of [cyclin D1] . Positive_regulation CCND1 KLF5 20037604 2192546 To elucidate how krüppel-like factor ( ) *activates* [cyclin D1] expression in Ang II-induced vascular smooth muscle cells ( VSMC ) proliferation . Positive_regulation CCND1 KLF5 20037604 2192550 is a downstream signal of the ERK 1/2 and p38 MAPK pathways , and *activates* the transcription of [cyclin D1] gene via functional interaction with c-Jun in Ang II-induced VSMC proliferation . Positive_regulation CCND1 KLF5 24236150 2868814 Taken together , our results demonstrate that is *required* for PDGF induced [Cyclin D1] expression , which is inhibited by TGFß via a Smad dependent mechanism , resulting in arrest of VSMCs in the G1 phase of the cell cycle . Positive_regulation CCND1 KLF8 12820964 1104079 Transcription activation of [cyclin D1] by FAK *requires* both Ets family and factors in a temporally differential manner . Positive_regulation CCND1 KLF8 21416054 2405543 Finally , *mediated* [cyclin D1] protein expression and cell cycle progression were significantly decreased in the K93R and K95R but increased in the K93Q , K95Q , K67R or K67Q mutant . Positive_regulation CCND1 KRAS 10340949 616230 Finally , the synthetic MEK inhibitor PD98059 blocked *induced* [cyclin D1] promoter activity . Positive_regulation CCND1 KRAS 10531005 561995 By microinjecting anti-Ras antibody , we found that the induction of [cyclin D1] expression beginning in G2 phase was *dependent* on activity . Positive_regulation CCND1 KRAS 10531005 561998 *dependent* induction of [cyclin D1] expression beginning in G2 phase is critical for continuous cell cycle progression in NIH3T3 cells . Positive_regulation CCND1 KRAS 10611246 656158 Induction of [cyclin D1] by NeuT *involved* , Rac , Rho , extracellular signal regulated kinase , c-Jun N-terminal kinase , and p38 , but not phosphatidylinositol 3-kinase . Positive_regulation CCND1 KRAS 10698514 671845 As already reported , oncogenic expression was *sufficient* to induce [cyclin D1] and p21cip1 expression and their association with cdk4 . Positive_regulation CCND1 KRAS 11159909 781453 Activation of and Erk *causes* induction of [cyclin D1-Cdk4] without increase of cyclin E or PCNA in ductal lesions . Positive_regulation CCND1 KRAS 11223027 787808 Thus , activity during G2 phase *induces* [cyclin D1] expression . Positive_regulation CCND1 KRAS 12082537 958578 In exponentially growing cells , oncogenic *had* no effect on proliferation rates , Erk phosphorylation , or the level of [cyclin D1] , and Ras-induction did not confer serum independent growth . Positive_regulation CCND1 KRAS 12082537 958590 in this setting , induction *prevented* full downregulation of [cyclin D1] and inactivation of Erk . Positive_regulation CCND1 KRAS 12202534 983084 The requirement for and the regulatory *role* of ERK2 in [cyclin D1] production and in cell proliferation suggest that the Ras/Raf/MEK/ERK pathway plays a key role in the control of RPE cell proliferation . Positive_regulation CCND1 KRAS 12386817 999800 To understand the mechanism of the dependent [cyclin D1] *induction* , cyclin D1 mRNA levels were determined by quantitative image analysis following fluorescent in situ hybridization . Positive_regulation CCND1 KRAS 12429909 1015093 These studies were designed to understand how could *induce* [cyclin D1] levels only during G2 phase . Positive_regulation CCND1 KRAS 12429909 1015099 This suggests that [cyclin D1] induction during G2 phase is not the *result* of activation specifically during this cell cycle period . Positive_regulation CCND1 KRAS 12505306 1026997 The hormone also causes a decrease of cyclin D1 gene transcription , and is able to antagonize the *activation* of the [cyclin D1] promoter by . Positive_regulation CCND1 KRAS 12648671 1070444 The decision to continue cell cycle progression takes place in G2 phase , when cellular *induces* the elevation of [cyclin D1] levels . Positive_regulation CCND1 KRAS 12794085 1120068 Although Ras , Raf , and MEK all increased expression of cyclin D1 on collagen film , only and Raf significantly *up-regulated* [cyclin D1] levels on collagen gel . Positive_regulation CCND1 KRAS 14657670 1188535 PAK is essential for *induced* upregulation of [cyclin D1] during the G1 to S transition . Positive_regulation CCND1 KRAS 14657670 1188545 In this report , using two distinct inhibitors specific for PAK1-3 ( CEP-1347 and WR-PAK18 ) , we present the first evidence indicating that the PIX/Rac/CDC42 dependent Ser/Thr kinases PAK1-3 , acting downstream of PI-3 kinase and upstream of the Raf/MEK/ERKs kinase cascade , is essential for *induced* upregulation of [cyclin D1] , but not downregulation of p27 . Positive_regulation CCND1 KRAS 15675969 1366392 Taken together , these results suggest that CWF inhibits the growth of dermal fibroblasts at least in part by decreasing the level of active , resulting in decreased *levels* of ppRb and [cyclin D1] . Positive_regulation CCND1 KRAS 15958613 1422838 Inhibition of active by farnesylthiosalicylic acid *led* to attenuation of the Raf-MEK-ERK and phosphoinositide 3-kinase-Akt-glycogen synthase-3 ( GSK-3 ) pathways , to reduction in [cyclin D1] , phospho-retinoblastoma , and E2F , and to increase in the cyclin dependent kinase inhibitor p27 and in retinoblastoma binding protein-1 , an inhibitor of E2F transcriptional activity . Positive_regulation CCND1 KRAS 18604165 1935597 However , more recent reports suggested that the commitment to cycle in response to serum occurs already in G ( 2 ) phase and requires the *dependent* induction of [cyclin D1] , which promotes following G ( 1 ) /S transition . Positive_regulation CCND1 KRAS 20717927 2345721 In MIA PaCa-2 cells in culture , LOX-PP attenuated the ERK and AKT activities and decreased the levels of the NF-?B p65 and RelB subunits and [cyclin D1] , which are *activated* by signaling . Positive_regulation CCND1 KRAS 20798689 2368247 ASPP2 suppresses *induced* small ubiquitin-like modifier (SUMO) modified nuclear [cyclin D1] and inhibits retinoblastoma protein ( Rb ) phosphorylation . Positive_regulation CCND1 KRAS 9199319 438900 Analysis of Cdk-cyclin complexes indicates that signaling is *required* both for induction of [cyclin D1] and for downregulation of the Cdk inhibitor p27KIP1 . Positive_regulation CCND1 KRAS 9407076 470824 Overexpression of dominant negative forms of or RhoA completely blocked PDGF induced p27 ( KIP1 ) degradation , but only dominant negative Ras *inhibited* [cyclin D1] protein expression . Positive_regulation CCND1 L1CAM 21097529 2395758 The downregulation of expression decreased renal cancer cell proliferation and *reduced* the expression of [cyclin D1] . Positive_regulation CCND1 LAMTOR5 21239735 2379832 The increase in [cyclinD(1)] protein levels *induced* by was inhibited when cells were incubated with LY294002 . Positive_regulation CCND1 LATS2 23267128 2718649 At the protein level , inhibition of *reduces* the expression of [cyclin-D1] and Nuclear Receptor Co-Repressor (NCoR) while increasing the expression of p27 . Positive_regulation CCND1 LEF1 17666529 1780496 Conversely , overexpression of HIPK2 suppresses mediated transcriptional *activation* of [cyclin D1] expression . Positive_regulation CCND1 LEF1 22792274 2628497 We found that during gland development [cyclin D1] is elevated and localized to the gland buds , and that this *requires* the presence of . Positive_regulation CCND1 LEP 15319373 1303761 *resulted* in a robust increase in [cyclin D1] expression . Positive_regulation CCND1 LEP 16825198 1606389 *increases* the expression of vascular endothelial growth factor ( VEGF ) , its receptor ( VEGF-R2 ) , and [cyclin D1] through phosphoinositide 3-kinase , Janus kinase 2/signal transducer and activator of transcription 3 , and/or extracellular signal activated kinase 1/2 signaling pathways . Positive_regulation CCND1 LEP 16825198 1606390 In contrast to *induced* levels of [cyclin D1] the changes in VEGF or VEGF-R2 were more dependent on specific signaling pathways . Positive_regulation CCND1 LEP 17303663 1726002 *mediated* decrease of cyclin A2 and increase of [cyclin D1] expression : relevance for the control of prepubertal rat Leydig cell division and differentiation . Positive_regulation CCND1 LEP 17344214 1726954 We also show specific involvement of coactivator molecules , histone acetyltransferase SRC1 , and mediator complex in *mediated* regulation of [CYCLIN D1] promoter . Positive_regulation CCND1 LEP 17639064 1771043 *stimulated* [cyclin D1] promoter activity to increase cyclin D1 protein expression , which accelerated the cell cycle progression . Positive_regulation CCND1 LEP 18988190 2015872 Mutagenesis studies , eletrophoretic mobility shift , and chromatin immunoprecipitation analysis revealed that signal transducers and activators of transcription 3 ( STAT3 ) and cyclic AMP-responsive element ( CRE ) binding protein motifs , within cyclin D1 promoter , were required for *induced* [cyclin D1] expression in Ishikawa endometrial cancer cells . Positive_regulation CCND1 LEP 20643953 2297771 We further show that can *induce* Bcl-2 and [cyclin D1] expression by two pathways , including the direct activation of their promoters and suppression of microRNAs ( miRNAs ) that target their putative 3'untranslated regions . Positive_regulation CCND1 LEP 21163886 2396286 Furthermore , overexpression of constitutively active Stat3 imparted significant protection against BITC mediated inhibition of cyclin D1 transactivation , whereas RNA interference of Stat3 resulted in a significant increase in BITC mediated inhibition of [cyclin D1] transactivation in the *presence* of . Positive_regulation CCND1 LEP 21163886 2396287 These results indicate that Stat3 plays an important role in BITC mediated inhibition of *induced* [cyclin D1] transactivation . Positive_regulation CCND1 LEP 22692856 2638675 *regulates* [cyclin D1] in luminal epithelial cells of mouse MMTV-Wnt-1 mammary tumors . Positive_regulation CCND1 LEP 22692856 2638677 In vitro studies indicate that *induces* expression of [cyclin D1] , a cell-cycle control protein necessary for mammary tumor development . Positive_regulation CCND1 LEP 22692856 2638678 [Cyclin D1] is expressed exclusively in luminal keratin 8 immunoreactive tumor cells and is *dependent* on the adipose secreted hormone . Positive_regulation CCND1 LEP 23300886 2712446 *induces* [cyclin D1] expression and proliferation of human nucleus pulposus cells via JAK/STAT , PI3K/Akt and MEK/ERK pathways . Positive_regulation CCND1 LEP 23300886 2712464 Pharmacological inhibition of JAK/STAT3 , PI3K/Akt or MEK/ERK signaling by AG490 , Wortmannin or U0126 , respectively , reduced *induced* [cyclin D1] expression and NP cell proliferation . Positive_regulation CCND1 LEP 23300886 2712474 Taken together , we show that *induces* human NP cell [cyclin D1] expression and proliferation via activation of JAK/STAT3 , PI3K/Akt or MEK/ERK signaling . Positive_regulation CCND1 LEP 23354006 2734191 Using western blot analysis , we found that *enhanced* the expression of [cyclin D1] and Mcl-1 , which are important regulators of cell proliferation and the inhibition of apoptosis . Positive_regulation CCND1 LEP 23354006 2734193 Our data demonstrate that *upregulates* the expression of [cyclin D1] and Mcl-1 to stimulate cell growth by activating the PI3K/Akt and MEK/ERK1/2 pathways in ovarian cancer . Positive_regulation CCND1 LGALS3 10463621 640212 Interestingly , *induces* [cyclin D1] expression ( an early G1 cyclin ) and its associated kinase activity in the absence of cell anchorage . Positive_regulation CCND1 LGALS3 12439750 1016872 *enhances* [cyclin D(1)] promoter activity through SP1 and a cAMP-responsive element in human breast epithelial cells . Positive_regulation CCND1 LGALS3 12439750 1016874 We found that *induces* [cyclin D(1)] promoter activity in human breast epithelial cells independent of cell adhesion through multiple cis-elements , including the SP1 and CRE sites . Positive_regulation CCND1 LGALS3 12439750 1016875 We present evidence that *induction* of the [cyclin D(1)] promoter may result from enhancement/stabilization of nuclear protein-DNA complex formation at the CRE site of the cyclin D(1) promoter . Positive_regulation CCND1 LGALS3 15520318 1335660 Recombinant *induced* cardiac fibroblast proliferation , collagen production , and [cyclin D1] expression . Positive_regulation CCND1 LIF 15572361 1368334 Knock-down of IFI16 using siRNA abrogated *induced* changes in cellular levels of E2F1 , [cyclin D1] , and p21WAF/CIP1 , and cell cycle arrest . Positive_regulation CCND1 LIF 22649064 2625905 The deficient response to LIF administration in the diabetic myoblasts was further emphasized by a lack of increase in *stimulated* cell proliferation and a decreased LIF stimulated induction of the proliferation promoting factors [cyclin D1] , JunB , and c-myc . SOCS3 protein was upregulated in diabetic myoblasts , and knockdown of SOCS3 rescued LIF induced gene expression in diabetic myoblasts , whereas neither STAT1 or STAT3 signaling nor proliferation rate was affected . Positive_regulation CCND1 LIN28A 22467868 2601330 Finally , using a combined gene expression microarray and bioinformatics approach , we found that also *regulates* [CCND1] and CDC25A expression and that this is mediated by inhibiting the biogenesis of let-7 miRNA . Positive_regulation CCND1 LMO4 19648968 2143374 Loss of subsequently *results* in reduced [Cyclin D1] and Cyclin E . Positive_regulation CCND1 LPA 12759391 1091079 *stimulated* [cyclin D1] promoter activity ( 3.0-fold , 95 % confidence interval [ CI ] = 2.7-fold to 3.3-fold ) . Positive_regulation CCND1 LPA 12759391 1091082 In addition to the previously characterized indirect mechanism that increases angiogenesis via VEGF , may directly *increase* the level of [cyclin D1] in ovarian cancer cells , increasing their proliferation . Positive_regulation CCND1 LPA 20724530 2335651 In vitro studies using HCT116 cells showed that *induced* [cyclin D1] , c-Myc , and HIF-1a expression , which was attenuated by knockdown of LPA ( 2 ) . Positive_regulation CCND1 LPA 22847216 2677045 Furthermore , *up-regulated* CRE harboring [cyclin D1] promoter activity , suggesting that CREB and cyclin D1 play significant roles in LPA induced proliferation of P19 embryonic carcinoma cells . Positive_regulation CCND1 LPA 23209312 2707815 In vivo , the administration of soluble RAGE or genetic deletion of RAGE mitigated *stimulated* vascular Akt signaling , autotaxin/LPA-driven phosphorylation of Akt and [cyclin D1] in the mammary tissue of transgenic mice vulnerable to carcinogenesis , and ovarian tumor implantation and development . Positive_regulation CCND1 LRRC59 12444543 1017443 Furthermore , ectopic expression of ( SEI-1 ) , a mitogen induced CDK4 binding protein , *increased* the levels of active [cyclinD1-CDK4] complex in asynchronously proliferating p21/p27-null MEFs . Positive_regulation CCND1 MAP2K1 10048449 592534 In contrast , constitutive active , the classical p42/44 MAPK activator , *increased* [cyclin D1] promoter activity and level of protein . Positive_regulation CCND1 MAP2K1 11196465 762043 But , the inhibitor , PD98059 ( 50microM ) , *inhibits* cFos and [cyclin D1] induction and DNA synthesis stimulation by both ACTH39 and FGF2 , suggesting that ERK1/2 activation mediates the strong and the weak mitogenic effect of , respectively , FGF2 and ACTH39 . Positive_regulation CCND1 MAP2K1 11349065 814493 [Cyclin D1] promoter activation by H. pylori was *inhibited* by inhibitors ( U0126 and PD98059 ) , indicating that the mitogen activated protein kinase pathway may be involved in intracellular signal transduction . Positive_regulation CCND1 MAP2K1 12581857 1058563 In the *presence* of the inhibitor , PD98059 , eIF4E phosphorylation was abolished and levels of [cyclin D1] were dramatically reduced . Positive_regulation CCND1 MAP2K1 12771941 1094837 Finally , both [cyclin D1] induction and HBX mitotic activity are *dependent* on p38 and c-Jun N-terminal kinase , but not on kinase activity . Positive_regulation CCND1 MAP2K1 12794085 1120069 Although Ras , Raf , and all *increased* expression of [cyclin D1] on collagen film , only Ras and Raf significantly up-regulated cyclin D1 levels on collagen gel . Positive_regulation CCND1 MAP2K1 15547725 1338347 Ectopic expression of activated in HepG2 cells *increased* [cyclin D1] and Cdk-2 expression , phosphorylation of pRB at Ser780 and Ser795 , and percentage of cells in S phase . Positive_regulation CCND1 MAP2K1 17941827 1849429 Inhibition of EGFR , PI3K ( phosphoinositide 3-kinase ; kinases required for Rac activation by HRG ) or [ MAPK ( mitogen activated protein kinase ) /ERK ( extracellular-signal regulated kinase ) kinase ] also *blocked* the up-regulation of [cyclin D1 and p21(Cip1)] by HRG . Positive_regulation CCND1 MAP2K1 19589865 2137049 Increased regulated kinase activity in human endometrial stromal fibroblasts of women with endometriosis *reduces* 3',5'-cyclic adenosine 5'-monophosphate inhibition of [cyclin D1] . Positive_regulation CCND1 MAP2K1 22579115 2609540 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated [Cyclin D1] and Cyclin B1 proteins as well as *activation* of PI3K/Akt and , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation CCND1 MAP2K1 23300886 2712465 Pharmacological inhibition of JAK/STAT3 , PI3K/Akt or signaling by AG490 , Wortmannin or U0126 , respectively , *reduced* leptin induced [cyclin D1] expression and NP cell proliferation . Positive_regulation CCND1 MAP2K1 23852369 2825176 Third , inhibition of was *sufficient* to eliminate [cyclin D1] , regardless of MTOR . Positive_regulation CCND1 MAP2K1 8702807 376063 Conversely , activation of this signaling pathway by expression of a constitutively active mutant dramatically *increased* [cyclin D1] promoter activity and cyclin D1 protein expression , in a growth factor independent manner . Positive_regulation CCND1 MAP2K1 9891045 586271 Activation of Raf , v-Src , and *led* to induced expression of c-Myc and [cyclin D1] . Positive_regulation CCND1 MAP2K2 11349065 814494 [Cyclin D1] promoter activation by H. pylori was *inhibited* by inhibitors ( U0126 and PD98059 ) , indicating that the mitogen activated protein kinase pathway may be involved in intracellular signal transduction . Positive_regulation CCND1 MAP2K2 12581857 1058564 In the presence of the inhibitor , PD98059 , eIF4E phosphorylation was abolished and levels of [cyclin D1] were dramatically *reduced* . Positive_regulation CCND1 MAP2K2 12794085 1120070 Although Ras , Raf , and all *increased* expression of [cyclin D1] on collagen film , only Ras and Raf significantly up-regulated cyclin D1 levels on collagen gel . Positive_regulation CCND1 MAP2K2 17941827 1849430 Inhibition of EGFR , PI3K ( phosphoinositide 3-kinase ; kinases required for Rac activation by HRG ) or [ MAPK ( mitogen activated protein kinase ) /ERK ( extracellular-signal regulated kinase ) kinase ] also *blocked* the up-regulation of [cyclin D1 and p21(Cip1)] by HRG . Positive_regulation CCND1 MAP2K2 19589865 2137050 Increased regulated kinase activity in human endometrial stromal fibroblasts of women with endometriosis *reduces* 3',5'-cyclic adenosine 5'-monophosphate inhibition of [cyclin D1] . Positive_regulation CCND1 MAP2K2 22579115 2609541 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated [Cyclin D1] and Cyclin B1 proteins as well as *activation* of PI3K/Akt and , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation CCND1 MAP2K2 23300886 2712466 Pharmacological inhibition of JAK/STAT3 , PI3K/Akt or signaling by AG490 , Wortmannin or U0126 , respectively , *reduced* leptin induced [cyclin D1] expression and NP cell proliferation . Positive_regulation CCND1 MAP2K2 23852369 2825177 Third , inhibition of was *sufficient* to eliminate [cyclin D1] , regardless of MTOR . Positive_regulation CCND1 MAP2K3 11349065 814495 [Cyclin D1] promoter activation by H. pylori was *inhibited* by inhibitors ( U0126 and PD98059 ) , indicating that the mitogen activated protein kinase pathway may be involved in intracellular signal transduction . Positive_regulation CCND1 MAP2K3 12581857 1058565 In the *presence* of the inhibitor , PD98059 , eIF4E phosphorylation was abolished and levels of [cyclin D1] were dramatically reduced . Positive_regulation CCND1 MAP2K3 12794085 1120071 Although Ras , Raf , and all *increased* expression of [cyclin D1] on collagen film , only Ras and Raf significantly up-regulated cyclin D1 levels on collagen gel . Positive_regulation CCND1 MAP2K3 17941827 1849431 Inhibition of EGFR , PI3K ( phosphoinositide 3-kinase ; kinases required for Rac activation by HRG ) or [ MAPK ( mitogen activated protein kinase ) /ERK ( extracellular-signal regulated kinase ) kinase ] also *blocked* the up-regulation of [cyclin D1 and p21(Cip1)] by HRG . Positive_regulation CCND1 MAP2K3 19589865 2137051 Increased regulated kinase activity in human endometrial stromal fibroblasts of women with endometriosis *reduces* 3',5'-cyclic adenosine 5'-monophosphate inhibition of [cyclin D1] . Positive_regulation CCND1 MAP2K3 22579115 2609542 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated [Cyclin D1] and Cyclin B1 proteins as well as *activation* of PI3K/Akt and , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation CCND1 MAP2K3 23300886 2712467 Pharmacological inhibition of JAK/STAT3 , PI3K/Akt or signaling by AG490 , Wortmannin or U0126 , respectively , *reduced* leptin induced [cyclin D1] expression and NP cell proliferation . Positive_regulation CCND1 MAP2K3 23852369 2825178 Third , inhibition of was *sufficient* to eliminate [cyclin D1] , regardless of MTOR . Positive_regulation CCND1 MAP2K4 11349065 814496 [Cyclin D1] promoter activation by H. pylori was *inhibited* by inhibitors ( U0126 and PD98059 ) , indicating that the mitogen activated protein kinase pathway may be involved in intracellular signal transduction . Positive_regulation CCND1 MAP2K4 12581857 1058566 In the presence of the inhibitor , PD98059 , eIF4E phosphorylation was abolished and levels of [cyclin D1] were dramatically *reduced* . Positive_regulation CCND1 MAP2K4 12794085 1120072 Although Ras , Raf , and all *increased* expression of [cyclin D1] on collagen film , only Ras and Raf significantly up-regulated cyclin D1 levels on collagen gel . Positive_regulation CCND1 MAP2K4 17941827 1849432 Inhibition of EGFR , PI3K ( phosphoinositide 3-kinase ; kinases required for Rac activation by HRG ) or [ MAPK ( mitogen activated protein kinase ) /ERK ( extracellular-signal regulated kinase ) kinase ] also *blocked* the up-regulation of [cyclin D1 and p21(Cip1)] by HRG . Positive_regulation CCND1 MAP2K4 19589865 2137052 Increased regulated kinase activity in human endometrial stromal fibroblasts of women with endometriosis *reduces* 3',5'-cyclic adenosine 5'-monophosphate inhibition of [cyclin D1] . Positive_regulation CCND1 MAP2K4 22579115 2609543 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated [Cyclin D1] and Cyclin B1 proteins as well as *activation* of PI3K/Akt and , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation CCND1 MAP2K4 23300886 2712468 Pharmacological inhibition of JAK/STAT3 , PI3K/Akt or signaling by AG490 , Wortmannin or U0126 , respectively , *reduced* leptin induced [cyclin D1] expression and NP cell proliferation . Positive_regulation CCND1 MAP2K4 23852369 2825179 Third , inhibition of was *sufficient* to eliminate [cyclin D1] , regardless of MTOR . Positive_regulation CCND1 MAP2K5 11349065 814497 [Cyclin D1] promoter activation by H. pylori was *inhibited* by inhibitors ( U0126 and PD98059 ) , indicating that the mitogen activated protein kinase pathway may be involved in intracellular signal transduction . Positive_regulation CCND1 MAP2K5 12581857 1058567 In the *presence* of the inhibitor , PD98059 , eIF4E phosphorylation was abolished and levels of [cyclin D1] were dramatically reduced . Positive_regulation CCND1 MAP2K5 12794085 1120073 Although Ras , Raf , and all *increased* expression of [cyclin D1] on collagen film , only Ras and Raf significantly up-regulated cyclin D1 levels on collagen gel . Positive_regulation CCND1 MAP2K5 17941827 1849433 Inhibition of EGFR , PI3K ( phosphoinositide 3-kinase ; kinases required for Rac activation by HRG ) or [ MAPK ( mitogen activated protein kinase ) /ERK ( extracellular-signal regulated kinase ) kinase ] also *blocked* the up-regulation of [cyclin D1 and p21(Cip1)] by HRG . Positive_regulation CCND1 MAP2K5 19589865 2137053 Increased regulated kinase activity in human endometrial stromal fibroblasts of women with endometriosis *reduces* 3',5'-cyclic adenosine 5'-monophosphate inhibition of [cyclin D1] . Positive_regulation CCND1 MAP2K5 22579115 2609544 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated [Cyclin D1] and Cyclin B1 proteins as well as *activation* of PI3K/Akt and , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation CCND1 MAP2K5 23300886 2712469 Pharmacological inhibition of JAK/STAT3 , PI3K/Akt or signaling by AG490 , Wortmannin or U0126 , respectively , *reduced* leptin induced [cyclin D1] expression and NP cell proliferation . Positive_regulation CCND1 MAP2K5 23852369 2825180 Third , inhibition of was *sufficient* to eliminate [cyclin D1] , regardless of MTOR . Positive_regulation CCND1 MAP2K6 11349065 814498 [Cyclin D1] promoter activation by H. pylori was *inhibited* by inhibitors ( U0126 and PD98059 ) , indicating that the mitogen activated protein kinase pathway may be involved in intracellular signal transduction . Positive_regulation CCND1 MAP2K6 12581857 1058568 In the presence of the inhibitor , PD98059 , eIF4E phosphorylation was abolished and levels of [cyclin D1] were dramatically *reduced* . Positive_regulation CCND1 MAP2K6 12794085 1120074 Although Ras , Raf , and all *increased* expression of [cyclin D1] on collagen film , only Ras and Raf significantly up-regulated cyclin D1 levels on collagen gel . Positive_regulation CCND1 MAP2K6 17941827 1849434 Inhibition of EGFR , PI3K ( phosphoinositide 3-kinase ; kinases required for Rac activation by HRG ) or [ MAPK ( mitogen activated protein kinase ) /ERK ( extracellular-signal regulated kinase ) kinase ] also *blocked* the up-regulation of [cyclin D1 and p21(Cip1)] by HRG . Positive_regulation CCND1 MAP2K6 19589865 2137054 Increased regulated kinase activity in human endometrial stromal fibroblasts of women with endometriosis *reduces* 3',5'-cyclic adenosine 5'-monophosphate inhibition of [cyclin D1] . Positive_regulation CCND1 MAP2K6 22579115 2609545 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated [Cyclin D1] and Cyclin B1 proteins as well as *activation* of PI3K/Akt and , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation CCND1 MAP2K6 23300886 2712470 Pharmacological inhibition of JAK/STAT3 , PI3K/Akt or signaling by AG490 , Wortmannin or U0126 , respectively , *reduced* leptin induced [cyclin D1] expression and NP cell proliferation . Positive_regulation CCND1 MAP2K6 23852369 2825181 Third , inhibition of was *sufficient* to eliminate [cyclin D1] , regardless of MTOR . Positive_regulation CCND1 MAP2K7 11349065 814499 [Cyclin D1] promoter activation by H. pylori was *inhibited* by inhibitors ( U0126 and PD98059 ) , indicating that the mitogen activated protein kinase pathway may be involved in intracellular signal transduction . Positive_regulation CCND1 MAP2K7 12581857 1058569 In the *presence* of the inhibitor , PD98059 , eIF4E phosphorylation was abolished and levels of [cyclin D1] were dramatically reduced . Positive_regulation CCND1 MAP2K7 12794085 1120075 Although Ras , Raf , and all *increased* expression of [cyclin D1] on collagen film , only Ras and Raf significantly up-regulated cyclin D1 levels on collagen gel . Positive_regulation CCND1 MAP2K7 17941827 1849435 Inhibition of EGFR , PI3K ( phosphoinositide 3-kinase ; kinases required for Rac activation by HRG ) or [ MAPK ( mitogen activated protein kinase ) /ERK ( extracellular-signal regulated kinase ) kinase ] also *blocked* the up-regulation of [cyclin D1 and p21(Cip1)] by HRG . Positive_regulation CCND1 MAP2K7 19589865 2137055 Increased regulated kinase activity in human endometrial stromal fibroblasts of women with endometriosis *reduces* 3',5'-cyclic adenosine 5'-monophosphate inhibition of [cyclin D1] . Positive_regulation CCND1 MAP2K7 22579115 2609546 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated [Cyclin D1] and Cyclin B1 proteins as well as *activation* of PI3K/Akt and , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation CCND1 MAP2K7 23300886 2712471 Pharmacological inhibition of JAK/STAT3 , PI3K/Akt or signaling by AG490 , Wortmannin or U0126 , respectively , *reduced* leptin induced [cyclin D1] expression and NP cell proliferation . Positive_regulation CCND1 MAP2K7 23852369 2825182 Third , inhibition of was *sufficient* to eliminate [cyclin D1] , regardless of MTOR . Positive_regulation CCND1 MAP3K12 21893036 2486956 Moreover , RNA interference experiments demonstrate that is *required* for ERK activity , expression of the cell cycle regulator [cyclin D1] and proliferation of WI-38 cells . Positive_regulation CCND1 MAP3K5 21187402 2378866 overexpression *induced* the transcription of [cyclin D1] , through AP-1 activation , and ASK1 levels were regulated by cyclin D1 , via the Rb-E2F pathway . Positive_regulation CCND1 MAP3K5 21187402 2378870 Exogenous *induced* [cyclin D1] expression , followed by elevated expression of endogenous ASK1 . Positive_regulation CCND1 MAPK1 10026216 591321 Inclusion of the EDA segment potentiated the ability of FN to induce expression of [cyclin D1] , hyperphosphorylation of pRb , and *activation* of mitogen activated protein kinase ( ERK2 ) . Positive_regulation CCND1 MAPK1 10082542 598288 Enforced long-term activation of p42/p44 by expression of the chimera DeltaRaf-1 : ER , which activates the p42/p44 MAPK cascade at the level of Raf , *enhanced* the expression of MKP1/2 and [cyclin D1] and , more importantly , restored the reentry of confluent cells into the cell cycle . Positive_regulation CCND1 MAPK1 11004713 734976 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping activation and c-Fos and [cyclin D1] *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation CCND1 MAPK1 11497244 846490 Activation of is *essential* for [cyclin D1] expression and provides a link between mitogenic signalling and cell cycle progression . Positive_regulation CCND1 MAPK1 12054565 951159 PD098059 and U0126 , two kinase inhibitors , and LY294002 , a PI3K inhibitor , significantly *blocked* thrombin induced [ ( 3 ) H ] thymidine incorporation and [cyclin D(1)] expression in ASM cells . Positive_regulation CCND1 MAPK1 12202534 983085 The requirement for Ras and the regulatory *role* of in [cyclin D1] production and in cell proliferation suggest that the Ras/Raf/MEK/ERK pathway plays a key role in the control of RPE cell proliferation . Positive_regulation CCND1 MAPK1 12242655 990007 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Positive_regulation CCND1 MAPK1 12614329 1065154 In cultures treated with EGF , LY341495 was also able to reduce the stimulation of the pathway , as well as the *induction* of [cyclin D1] . Positive_regulation CCND1 MAPK1 12654183 1072966 may *induce* overexpression of [cyclin D1] protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation CCND1 MAPK1 12763029 1093773 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Positive_regulation CCND1 MAPK1 12816877 1134437 This overexpression inhibited PDGF induced expression of [cyclin D1] in the *presence* of unaffected activation . Positive_regulation CCND1 MAPK1 15020686 1221642 Double stranded small RNA interference ( siRNA ) by silencing endogenous p130Cas protein , was sufficient to inhibit estrogen dependent MAPKs activity and [cyclin D1] *induction* , demonstrating the requirement of p130Cas in such events . Positive_regulation CCND1 MAPK1 15095291 1238429 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Positive_regulation CCND1 MAPK1 15634644 1349536 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 , and down-regulation of [cyclin D1] . Positive_regulation CCND1 MAPK1 17205132 1663876 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Positive_regulation CCND1 MAPK1 18321550 1919543 Progestin induction of [CCND1] was observed in cells expressing PR-B but not PR-BDeltaSH3 or PR-A and induction in the presence of PR-B was dramatically *reduced* in the presence of inhibitors of Src or . Positive_regulation CCND1 MAPK1 18640102 1947660 Enantioselective effect of 12 ( S ) -hydroxyeicosatetraenoic acid on 3T6 fibroblast growth through ERK 1/2 and p38 pathways and [cyclin D1] *activation* . Positive_regulation CCND1 MAPK1 18692155 2020167 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to *dependent* activation of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Positive_regulation CCND1 MAPK1 19589865 2137070 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of [CCND1] , but not cAMP up-regulation of IGFBP1 , in hESF of women with vs. without endometriosis . Positive_regulation CCND1 MAPK1 22611193 2610354 Cell cycle quiescence is associated with down-regulation of [cyclin D1] , up-regulation of the cyclin dependent kinase inhibitors , p21 ( cip1. ) and p16(INK4a) , and Forkhead transcriptional factor 1 ( Foxo1 ) , and *activation* of p38 , indicating that H-Cx43-deficient HSCs are prone to senescence . Positive_regulation CCND1 MAPK1 23237355 2711155 Essential oil activated the caspase dependent apoptotic pathway , *induced* a rapid and transient activation of Akt and , and suppressed levels of [cyclin D1 cdk4] expression in cultured pancreatic cancer cells . Positive_regulation CCND1 MAPK1 24008581 2845917 Inhibitors of PI3K or *inhibited* [cyclin D1] expression and G1 progression when added 12 hours after EGF stimulation , whereas depletion of EGF from the medium at this time point did not . Positive_regulation CCND1 MAPK1 24375433 2917199 While secondary stimulation resulted in strongly decreased replication rate , we did not observe any attenuation of morphological changes , phosphorylation and [cyclin D1] *induction* . Positive_regulation CCND1 MAPK1 7559524 323590 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized dependent *induction* of [cyclin D1] promoter activity . Positive_regulation CCND1 MAPK1 9537433 497576 In conclusion , these findings suggest that MAPK/ERK activation in human HCC may play an important role in multistep hepatocarcinogenesis , especially in the progression of HCC; at least in part , through [cyclin D1] up-regulation primarily *induced* by via c-Fos . Positive_regulation CCND1 MAPK10 10082542 598289 Enforced long-term activation of p42/p44 by expression of the chimera DeltaRaf-1 : ER , which activates the p42/p44 MAPK cascade at the level of Raf , *enhanced* the expression of MKP1/2 and [cyclin D1] and , more importantly , restored the reentry of confluent cells into the cell cycle . Positive_regulation CCND1 MAPK10 11004713 734977 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping activation and c-Fos and [cyclin D1] *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation CCND1 MAPK10 11497244 846491 Activation of is *essential* for [cyclin D1] expression and provides a link between mitogenic signalling and cell cycle progression . Positive_regulation CCND1 MAPK10 12054565 951160 PD098059 and U0126 , two kinase inhibitors , and LY294002 , a PI3K inhibitor , significantly *blocked* thrombin induced [ ( 3 ) H ] thymidine incorporation and [cyclin D(1)] expression in ASM cells . Positive_regulation CCND1 MAPK10 12242655 990008 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Positive_regulation CCND1 MAPK10 12614329 1065155 In cultures treated with EGF , LY341495 was also able to reduce the stimulation of the pathway , as well as the *induction* of [cyclin D1] . Positive_regulation CCND1 MAPK10 12654183 1072967 may *induce* overexpression of [cyclin D1] protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation CCND1 MAPK10 12763029 1093774 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Positive_regulation CCND1 MAPK10 12816877 1134438 This overexpression inhibited PDGF induced expression of [cyclin D1] in the *presence* of unaffected activation . Positive_regulation CCND1 MAPK10 15095291 1238430 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Positive_regulation CCND1 MAPK10 15634644 1349537 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 , and down-regulation of [cyclin D1] . Positive_regulation CCND1 MAPK10 17205132 1663877 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Positive_regulation CCND1 MAPK10 18321550 1919544 Progestin induction of [CCND1] was observed in cells expressing PR-B but not PR-BDeltaSH3 or PR-A and induction in the presence of PR-B was dramatically *reduced* in the presence of inhibitors of Src or . Positive_regulation CCND1 MAPK10 18640102 1947661 Enantioselective effect of 12 ( S ) -hydroxyeicosatetraenoic acid on 3T6 fibroblast growth through ERK 1/2 and p38 pathways and [cyclin D1] *activation* . Positive_regulation CCND1 MAPK10 18692155 2020168 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to dependent *activation* of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Positive_regulation CCND1 MAPK10 19589865 2137071 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of [CCND1] , but not cAMP up-regulation of IGFBP1 , in hESF of women with vs. without endometriosis . Positive_regulation CCND1 MAPK10 22611193 2610355 Cell cycle quiescence is associated with down-regulation of [cyclin D1] , up-regulation of the cyclin dependent kinase inhibitors , p21 ( cip1. ) and p16(INK4a) , and Forkhead transcriptional factor 1 ( Foxo1 ) , and *activation* of p38 , indicating that H-Cx43-deficient HSCs are prone to senescence . Positive_regulation CCND1 MAPK10 7559524 323591 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized *dependent* induction of [cyclin D1] promoter activity . Positive_regulation CCND1 MAPK10 9537433 497577 In conclusion , these findings suggest that MAPK/ERK activation in human HCC may play an important role in multistep hepatocarcinogenesis , especially in the progression of HCC; at least in part , through [cyclin D1] up-regulation primarily *induced* by via c-Fos . Positive_regulation CCND1 MAPK11 10082542 598290 Enforced long-term activation of p42/p44 by expression of the chimera DeltaRaf-1 : ER , which activates the p42/p44 MAPK cascade at the level of Raf , *enhanced* the expression of MKP1/2 and [cyclin D1] and , more importantly , restored the reentry of confluent cells into the cell cycle . Positive_regulation CCND1 MAPK11 11004713 734978 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping activation and c-Fos and [cyclin D1] *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation CCND1 MAPK11 11497244 846492 Activation of is *essential* for [cyclin D1] expression and provides a link between mitogenic signalling and cell cycle progression . Positive_regulation CCND1 MAPK11 12054565 951161 PD098059 and U0126 , two kinase inhibitors , and LY294002 , a PI3K inhibitor , significantly *blocked* thrombin induced [ ( 3 ) H ] thymidine incorporation and [cyclin D(1)] expression in ASM cells . Positive_regulation CCND1 MAPK11 12242655 990009 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Positive_regulation CCND1 MAPK11 12614329 1065156 In cultures treated with EGF , LY341495 was also able to reduce the stimulation of the pathway , as well as the *induction* of [cyclin D1] . Positive_regulation CCND1 MAPK11 12654183 1072968 may *induce* overexpression of [cyclin D1] protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation CCND1 MAPK11 12763029 1093775 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Positive_regulation CCND1 MAPK11 12816877 1134439 This overexpression inhibited PDGF induced expression of [cyclin D1] in the *presence* of unaffected activation . Positive_regulation CCND1 MAPK11 15095291 1238431 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Positive_regulation CCND1 MAPK11 15634644 1349538 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 , and down-regulation of [cyclin D1] . Positive_regulation CCND1 MAPK11 17205132 1663878 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Positive_regulation CCND1 MAPK11 18321550 1919545 Progestin induction of [CCND1] was observed in cells expressing PR-B but not PR-BDeltaSH3 or PR-A and induction in the presence of PR-B was dramatically *reduced* in the presence of inhibitors of Src or . Positive_regulation CCND1 MAPK11 18640102 1947662 Enantioselective effect of 12 ( S ) -hydroxyeicosatetraenoic acid on 3T6 fibroblast growth through ERK 1/2 and p38 pathways and [cyclin D1] *activation* . Positive_regulation CCND1 MAPK11 18692155 2020169 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to *dependent* activation of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Positive_regulation CCND1 MAPK11 19589865 2137072 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of [CCND1] , but not cAMP up-regulation of IGFBP1 , in hESF of women with vs. without endometriosis . Positive_regulation CCND1 MAPK11 21911485 2516046 Here , we show that both genetic and pharmacologic inhibition of in glioblastoma multiforme cells significantly *reduces* rapamycin induced IRES mediated translation initiation of [cyclin D1] and c-MYC , resulting in increased G ( 1 ) arrest in vitro and inhibition of tumor growth in xenografts . Positive_regulation CCND1 MAPK11 22611193 2610356 Cell cycle quiescence is associated with down-regulation of [cyclin D1] , up-regulation of the cyclin dependent kinase inhibitors , p21 ( cip1. ) and p16(INK4a) , and Forkhead transcriptional factor 1 ( Foxo1 ) , and *activation* of p38 , indicating that H-Cx43-deficient HSCs are prone to senescence . Positive_regulation CCND1 MAPK11 7559524 323592 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized dependent *induction* of [cyclin D1] promoter activity . Positive_regulation CCND1 MAPK11 9537433 497578 In conclusion , these findings suggest that MAPK/ERK activation in human HCC may play an important role in multistep hepatocarcinogenesis , especially in the progression of HCC; at least in part , through [cyclin D1] up-regulation primarily *induced* by via c-Fos . Positive_regulation CCND1 MAPK12 10082542 598291 Enforced long-term activation of p42/p44 by expression of the chimera DeltaRaf-1 : ER , which activates the p42/p44 MAPK cascade at the level of Raf , *enhanced* the expression of MKP1/2 and [cyclin D1] and , more importantly , restored the reentry of confluent cells into the cell cycle . Positive_regulation CCND1 MAPK12 11004713 734979 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping activation and c-Fos and [cyclin D1] *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation CCND1 MAPK12 11497244 846493 Activation of is *essential* for [cyclin D1] expression and provides a link between mitogenic signalling and cell cycle progression . Positive_regulation CCND1 MAPK12 12054565 951162 PD098059 and U0126 , two kinase inhibitors , and LY294002 , a PI3K inhibitor , significantly *blocked* thrombin induced [ ( 3 ) H ] thymidine incorporation and [cyclin D(1)] expression in ASM cells . Positive_regulation CCND1 MAPK12 12242655 990010 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Positive_regulation CCND1 MAPK12 12614329 1065157 In cultures treated with EGF , LY341495 was also able to reduce the stimulation of the pathway , as well as the *induction* of [cyclin D1] . Positive_regulation CCND1 MAPK12 12654183 1072969 may *induce* overexpression of [cyclin D1] protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation CCND1 MAPK12 12763029 1093776 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Positive_regulation CCND1 MAPK12 12816877 1134440 This overexpression inhibited PDGF induced expression of [cyclin D1] in the *presence* of unaffected activation . Positive_regulation CCND1 MAPK12 15095291 1238432 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Positive_regulation CCND1 MAPK12 15634644 1349539 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 , and down-regulation of [cyclin D1] . Positive_regulation CCND1 MAPK12 17205132 1663879 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Positive_regulation CCND1 MAPK12 18321550 1919546 Progestin induction of [CCND1] was observed in cells expressing PR-B but not PR-BDeltaSH3 or PR-A and induction in the presence of PR-B was dramatically *reduced* in the presence of inhibitors of Src or . Positive_regulation CCND1 MAPK12 18640102 1947663 Enantioselective effect of 12 ( S ) -hydroxyeicosatetraenoic acid on 3T6 fibroblast growth through ERK 1/2 and p38 pathways and [cyclin D1] *activation* . Positive_regulation CCND1 MAPK12 18692155 2020170 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to dependent *activation* of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Positive_regulation CCND1 MAPK12 19589865 2137073 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of [CCND1] , but not cAMP up-regulation of IGFBP1 , in hESF of women with vs. without endometriosis . Positive_regulation CCND1 MAPK12 22611193 2610357 Cell cycle quiescence is associated with down-regulation of [cyclin D1] , up-regulation of the cyclin dependent kinase inhibitors , p21 ( cip1. ) and p16(INK4a) , and Forkhead transcriptional factor 1 ( Foxo1 ) , and *activation* of p38 , indicating that H-Cx43-deficient HSCs are prone to senescence . Positive_regulation CCND1 MAPK12 7559524 323593 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized *dependent* induction of [cyclin D1] promoter activity . Positive_regulation CCND1 MAPK12 9537433 497579 In conclusion , these findings suggest that MAPK/ERK activation in human HCC may play an important role in multistep hepatocarcinogenesis , especially in the progression of HCC; at least in part , through [cyclin D1] up-regulation primarily *induced* by via c-Fos . Positive_regulation CCND1 MAPK13 10082542 598292 Enforced long-term activation of p42/p44 by expression of the chimera DeltaRaf-1 : ER , which activates the p42/p44 MAPK cascade at the level of Raf , *enhanced* the expression of MKP1/2 and [cyclin D1] and , more importantly , restored the reentry of confluent cells into the cell cycle . Positive_regulation CCND1 MAPK13 11004713 734980 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping activation and c-Fos and [cyclin D1] *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation CCND1 MAPK13 11497244 846494 Activation of is *essential* for [cyclin D1] expression and provides a link between mitogenic signalling and cell cycle progression . Positive_regulation CCND1 MAPK13 12054565 951163 PD098059 and U0126 , two kinase inhibitors , and LY294002 , a PI3K inhibitor , significantly *blocked* thrombin induced [ ( 3 ) H ] thymidine incorporation and [cyclin D(1)] expression in ASM cells . Positive_regulation CCND1 MAPK13 12242655 990011 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Positive_regulation CCND1 MAPK13 12614329 1065158 In cultures treated with EGF , LY341495 was also able to reduce the stimulation of the pathway , as well as the *induction* of [cyclin D1] . Positive_regulation CCND1 MAPK13 12654183 1072970 may *induce* overexpression of [cyclin D1] protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation CCND1 MAPK13 12763029 1093777 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Positive_regulation CCND1 MAPK13 12816877 1134441 This overexpression inhibited PDGF induced expression of [cyclin D1] in the *presence* of unaffected activation . Positive_regulation CCND1 MAPK13 15095291 1238433 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Positive_regulation CCND1 MAPK13 15634644 1349540 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 , and down-regulation of [cyclin D1] . Positive_regulation CCND1 MAPK13 17205132 1663880 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Positive_regulation CCND1 MAPK13 18321550 1919547 Progestin induction of [CCND1] was observed in cells expressing PR-B but not PR-BDeltaSH3 or PR-A and induction in the presence of PR-B was dramatically *reduced* in the presence of inhibitors of Src or . Positive_regulation CCND1 MAPK13 18640102 1947664 Enantioselective effect of 12 ( S ) -hydroxyeicosatetraenoic acid on 3T6 fibroblast growth through ERK 1/2 and p38 pathways and [cyclin D1] *activation* . Positive_regulation CCND1 MAPK13 18692155 2020171 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to *dependent* activation of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Positive_regulation CCND1 MAPK13 19589865 2137074 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of [CCND1] , but not cAMP up-regulation of IGFBP1 , in hESF of women with vs. without endometriosis . Positive_regulation CCND1 MAPK13 22611193 2610358 Cell cycle quiescence is associated with down-regulation of [cyclin D1] , up-regulation of the cyclin dependent kinase inhibitors , p21 ( cip1. ) and p16(INK4a) , and Forkhead transcriptional factor 1 ( Foxo1 ) , and *activation* of p38 , indicating that H-Cx43-deficient HSCs are prone to senescence . Positive_regulation CCND1 MAPK13 7559524 323594 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized dependent *induction* of [cyclin D1] promoter activity . Positive_regulation CCND1 MAPK13 9537433 497580 In conclusion , these findings suggest that MAPK/ERK activation in human HCC may play an important role in multistep hepatocarcinogenesis , especially in the progression of HCC; at least in part , through [cyclin D1] up-regulation primarily *induced* by via c-Fos . Positive_regulation CCND1 MAPK14 10082542 598293 Enforced long-term activation of p42/p44 by expression of the chimera DeltaRaf-1 : ER , which activates the p42/p44 MAPK cascade at the level of Raf , *enhanced* the expression of MKP1/2 and [cyclin D1] and , more importantly , restored the reentry of confluent cells into the cell cycle . Positive_regulation CCND1 MAPK14 11004713 734981 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping activation and c-Fos and [cyclin D1] *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation CCND1 MAPK14 11497244 846495 Activation of is *essential* for [cyclin D1] expression and provides a link between mitogenic signalling and cell cycle progression . Positive_regulation CCND1 MAPK14 12054565 951164 PD098059 and U0126 , two kinase inhibitors , and LY294002 , a PI3K inhibitor , significantly *blocked* thrombin induced [ ( 3 ) H ] thymidine incorporation and [cyclin D(1)] expression in ASM cells . Positive_regulation CCND1 MAPK14 12242655 990012 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Positive_regulation CCND1 MAPK14 12614329 1065159 In cultures treated with EGF , LY341495 was also able to reduce the stimulation of the pathway , as well as the *induction* of [cyclin D1] . Positive_regulation CCND1 MAPK14 12654183 1072971 may *induce* overexpression of [cyclin D1] protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation CCND1 MAPK14 12763029 1093778 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Positive_regulation CCND1 MAPK14 12816877 1134442 This overexpression inhibited PDGF induced expression of [cyclin D1] in the *presence* of unaffected activation . Positive_regulation CCND1 MAPK14 15095291 1238434 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Positive_regulation CCND1 MAPK14 15634644 1349541 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 , and down-regulation of [cyclin D1] . Positive_regulation CCND1 MAPK14 17205132 1663881 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Positive_regulation CCND1 MAPK14 18321550 1919548 Progestin induction of [CCND1] was observed in cells expressing PR-B but not PR-BDeltaSH3 or PR-A and induction in the presence of PR-B was dramatically *reduced* in the presence of inhibitors of Src or . Positive_regulation CCND1 MAPK14 18640102 1947665 Enantioselective effect of 12 ( S ) -hydroxyeicosatetraenoic acid on 3T6 fibroblast growth through ERK 1/2 and p38 pathways and [cyclin D1] *activation* . Positive_regulation CCND1 MAPK14 18692155 2020172 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to dependent *activation* of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Positive_regulation CCND1 MAPK14 19589865 2137075 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of [CCND1] , but not cAMP up-regulation of IGFBP1 , in hESF of women with vs. without endometriosis . Positive_regulation CCND1 MAPK14 22611193 2610359 Cell cycle quiescence is associated with down-regulation of [cyclin D1] , up-regulation of the cyclin dependent kinase inhibitors , p21 ( cip1. ) and p16(INK4a) , and Forkhead transcriptional factor 1 ( Foxo1 ) , and *activation* of p38 , indicating that H-Cx43-deficient HSCs are prone to senescence . Positive_regulation CCND1 MAPK14 7559524 323595 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized *dependent* induction of [cyclin D1] promoter activity . Positive_regulation CCND1 MAPK14 9537433 497581 In conclusion , these findings suggest that MAPK/ERK activation in human HCC may play an important role in multistep hepatocarcinogenesis , especially in the progression of HCC; at least in part , through [cyclin D1] up-regulation primarily *induced* by via c-Fos . Positive_regulation CCND1 MAPK15 10082542 598287 Enforced long-term activation of p42/p44 by expression of the chimera DeltaRaf-1 : ER , which activates the p42/p44 MAPK cascade at the level of Raf , *enhanced* the expression of MKP1/2 and [cyclin D1] and , more importantly , restored the reentry of confluent cells into the cell cycle . Positive_regulation CCND1 MAPK15 11004713 734974 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping activation and c-Fos and [cyclin D1] *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation CCND1 MAPK15 11497244 846489 Activation of is *essential* for [cyclin D1] expression and provides a link between mitogenic signalling and cell cycle progression . Positive_regulation CCND1 MAPK15 12054565 951158 PD098059 and U0126 , two kinase inhibitors , and LY294002 , a PI3K inhibitor , significantly *blocked* thrombin induced [ ( 3 ) H ] thymidine incorporation and [cyclin D(1)] expression in ASM cells . Positive_regulation CCND1 MAPK15 12242655 990006 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Positive_regulation CCND1 MAPK15 12614329 1065153 In cultures treated with EGF , LY341495 was also able to reduce the stimulation of the pathway , as well as the *induction* of [cyclin D1] . Positive_regulation CCND1 MAPK15 12654183 1072965 may *induce* overexpression of [cyclin D1] protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation CCND1 MAPK15 12763029 1093772 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Positive_regulation CCND1 MAPK15 12816877 1134436 This overexpression inhibited PDGF induced expression of [cyclin D1] in the *presence* of unaffected activation . Positive_regulation CCND1 MAPK15 15095291 1238428 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Positive_regulation CCND1 MAPK15 15634644 1349535 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 , and down-regulation of [cyclin D1] . Positive_regulation CCND1 MAPK15 17205132 1663875 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Positive_regulation CCND1 MAPK15 18321550 1919542 Progestin induction of [CCND1] was observed in cells expressing PR-B but not PR-BDeltaSH3 or PR-A and induction in the presence of PR-B was dramatically *reduced* in the presence of inhibitors of Src or . Positive_regulation CCND1 MAPK15 18640102 1947659 Enantioselective effect of 12 ( S ) -hydroxyeicosatetraenoic acid on 3T6 fibroblast growth through ERK 1/2 and p38 pathways and [cyclin D1] *activation* . Positive_regulation CCND1 MAPK15 18692155 2020166 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to dependent *activation* of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Positive_regulation CCND1 MAPK15 19589865 2137069 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of [CCND1] , but not cAMP up-regulation of IGFBP1 , in hESF of women with vs. without endometriosis . Positive_regulation CCND1 MAPK15 22611193 2610353 Cell cycle quiescence is associated with down-regulation of [cyclin D1] , up-regulation of the cyclin dependent kinase inhibitors , p21 ( cip1. ) and p16(INK4a) , and Forkhead transcriptional factor 1 ( Foxo1 ) , and *activation* of p38 , indicating that H-Cx43-deficient HSCs are prone to senescence . Positive_regulation CCND1 MAPK15 7559524 323589 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized *dependent* induction of [cyclin D1] promoter activity . Positive_regulation CCND1 MAPK15 9537433 497574 In conclusion , these findings suggest that MAPK/ERK activation in human HCC may play an important role in multistep hepatocarcinogenesis , especially in the progression of HCC; at least in part , through [cyclin D1] up-regulation primarily *induced* by via c-Fos . Positive_regulation CCND1 MAPK3 10082542 598294 Enforced long-term activation of p42/p44 by expression of the chimera DeltaRaf-1 : ER , which activates the p42/p44 MAPK cascade at the level of Raf , *enhanced* the expression of MKP1/2 and [cyclin D1] and , more importantly , restored the reentry of confluent cells into the cell cycle . Positive_regulation CCND1 MAPK3 11004713 734982 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping activation and c-Fos and [cyclin D1] *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation CCND1 MAPK3 11497244 846496 Activation of is *essential* for [cyclin D1] expression and provides a link between mitogenic signalling and cell cycle progression . Positive_regulation CCND1 MAPK3 12054565 951165 PD098059 and U0126 , two kinase inhibitors , and LY294002 , a PI3K inhibitor , significantly *blocked* thrombin induced [ ( 3 ) H ] thymidine incorporation and [cyclin D(1)] expression in ASM cells . Positive_regulation CCND1 MAPK3 12242655 990013 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Positive_regulation CCND1 MAPK3 12614329 1065160 In cultures treated with EGF , LY341495 was also able to reduce the stimulation of the pathway , as well as the *induction* of [cyclin D1] . Positive_regulation CCND1 MAPK3 12654183 1072972 may *induce* overexpression of [cyclin D1] protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation CCND1 MAPK3 12763029 1093779 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Positive_regulation CCND1 MAPK3 12816877 1134443 This overexpression inhibited PDGF induced expression of [cyclin D1] in the *presence* of unaffected activation . Positive_regulation CCND1 MAPK3 14592948 1200013 IGF-I elicited a time dependent increase in [cyclin D1] protein levels *mediated* jointly by dependent and PI3-kinase dependent mechanisms . Positive_regulation CCND1 MAPK3 15020686 1221643 Double stranded small RNA interference ( siRNA ) by silencing endogenous p130Cas protein , was sufficient to inhibit estrogen dependent MAPKs activity and [cyclin D1] *induction* , demonstrating the requirement of p130Cas in such events . Positive_regulation CCND1 MAPK3 15070810 1265689 Trypsinization of high-density MDCK cells immediately increased and was *followed* by a transient increase in [cyclin D1] levels . Positive_regulation CCND1 MAPK3 15095291 1238435 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Positive_regulation CCND1 MAPK3 15634644 1349542 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 , and down-regulation of [cyclin D1] . Positive_regulation CCND1 MAPK3 16522741 1531498 Although EX induced phosphorylation of Raf-1 and extracellular-signal regulated kinase ( ERK ) , both PD98059 and exogenous *had* no effect on the [cyclin D1] induction by EX . Positive_regulation CCND1 MAPK3 16638579 1552932 We also show that , but not p38MAPK activation is *required* to induce [cyclin D1] expression , strongly suggesting that the concerted action of cyclin D1 gene expression and other events are required to induce complete phosphorylation of retinoblastoma protein and S-phase entry in response to PGF2alpha . Positive_regulation CCND1 MAPK3 17055752 1683906 The data showed overexpression of [cyclin D1] and increased expression and *activation* of , p38 kinase and JNK1/2 with progression of tumor suggesting that MAP kinases play an important role during tumorigenesis . Positive_regulation CCND1 MAPK3 17205132 1663882 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Positive_regulation CCND1 MAPK3 18321550 1919549 Progestin induction of [CCND1] was observed in cells expressing PR-B but not PR-BDeltaSH3 or PR-A and induction in the presence of PR-B was dramatically *reduced* in the presence of inhibitors of Src or . Positive_regulation CCND1 MAPK3 18640102 1947666 Enantioselective effect of 12 ( S ) -hydroxyeicosatetraenoic acid on 3T6 fibroblast growth through ERK 1/2 and p38 pathways and [cyclin D1] *activation* . Positive_regulation CCND1 MAPK3 18692155 2020173 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to *dependent* activation of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Positive_regulation CCND1 MAPK3 19589865 2137076 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of [CCND1] , but not cAMP up-regulation of IGFBP1 , in hESF of women with vs. without endometriosis . Positive_regulation CCND1 MAPK3 20080131 2218716 We further show that IKKalpha dependent downregulation of Cyclin D1 expression in the UVB response results from the reduction of *dependent* [Cyclin D1] transcription coupled with an increase of p38 kinase dependent Cyclin D1 proteolysis . Positive_regulation CCND1 MAPK3 20694826 2430876 Cf-PS treatment induced the translocation of ß-catenin , an effector of the Wnt signaling pathway , from the cytosol to the nucleus and increased the expression of [cyclinD1] and c-myc. Cf-PS also *induced* phosphorylation , which is activated by mitogenic and proliferative stimuli such as growth factors , but the phosphorylation of JNK and p38 was not enhanced . Positive_regulation CCND1 MAPK3 22054946 2503951 Further , Cf-PS treatment induced the translocation of ß-catenin , an effector of the Wnt signaling pathway , from the cytosol to the nucleus and increased the expression of [cyclinD1] and c-myc. Cf-PS also *induced* phosphorylation , which is activated by mitogenic and proliferative stimuli such as growth factors , but the phosphorylation of JNK and p38 was not enhanced . Positive_regulation CCND1 MAPK3 22611193 2610360 Cell cycle quiescence is associated with down-regulation of [cyclin D1] , up-regulation of the cyclin dependent kinase inhibitors , p21 ( cip1. ) and p16(INK4a) , and Forkhead transcriptional factor 1 ( Foxo1 ) , and *activation* of p38 , indicating that H-Cx43-deficient HSCs are prone to senescence . Positive_regulation CCND1 MAPK3 23237355 2711156 Essential oil activated the caspase dependent apoptotic pathway , *induced* a rapid and transient activation of Akt and , and suppressed levels of [cyclin D1 cdk4] expression in cultured pancreatic cancer cells . Positive_regulation CCND1 MAPK3 24008581 2845918 Inhibitors of PI3K or *inhibited* [cyclin D1] expression and G1 progression when added 12 hours after EGF stimulation , whereas depletion of EGF from the medium at this time point did not . Positive_regulation CCND1 MAPK3 24375433 2917200 While secondary stimulation resulted in strongly decreased replication rate , we did not observe any attenuation of morphological changes , phosphorylation and [cyclin D1] *induction* . Positive_regulation CCND1 MAPK3 7559524 323596 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized dependent *induction* of [cyclin D1] promoter activity . Positive_regulation CCND1 MAPK3 8702807 376058 [Cyclin D1] expression is *regulated* positively by the and negatively by the p38/HOGMAPK pathway . Positive_regulation CCND1 MAPK3 9337851 458247 Sustained activation of ( ERK1 ) is *required* for the continued expression of [cyclin D1] in G1 phase . Positive_regulation CCND1 MAPK3 9537433 497582 In conclusion , these findings suggest that MAPK/ERK activation in human HCC may play an important role in multistep hepatocarcinogenesis , especially in the progression of HCC; at least in part , through [cyclin D1] up-regulation primarily *induced* by via c-Fos . Positive_regulation CCND1 MAPK4 10082542 598295 Enforced long-term activation of p42/p44 by expression of the chimera DeltaRaf-1 : ER , which activates the p42/p44 MAPK cascade at the level of Raf , *enhanced* the expression of MKP1/2 and [cyclin D1] and , more importantly , restored the reentry of confluent cells into the cell cycle . Positive_regulation CCND1 MAPK4 11004713 734983 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping activation and c-Fos and [cyclin D1] *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation CCND1 MAPK4 11497244 846497 Activation of is *essential* for [cyclin D1] expression and provides a link between mitogenic signalling and cell cycle progression . Positive_regulation CCND1 MAPK4 12054565 951166 PD098059 and U0126 , two kinase inhibitors , and LY294002 , a PI3K inhibitor , significantly *blocked* thrombin induced [ ( 3 ) H ] thymidine incorporation and [cyclin D(1)] expression in ASM cells . Positive_regulation CCND1 MAPK4 12242655 990014 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Positive_regulation CCND1 MAPK4 12614329 1065161 In cultures treated with EGF , LY341495 was also able to reduce the stimulation of the pathway , as well as the *induction* of [cyclin D1] . Positive_regulation CCND1 MAPK4 12654183 1072973 may *induce* overexpression of [cyclin D1] protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation CCND1 MAPK4 12763029 1093780 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Positive_regulation CCND1 MAPK4 12816877 1134444 This overexpression inhibited PDGF induced expression of [cyclin D1] in the *presence* of unaffected activation . Positive_regulation CCND1 MAPK4 15095291 1238436 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Positive_regulation CCND1 MAPK4 15634644 1349543 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 , and down-regulation of [cyclin D1] . Positive_regulation CCND1 MAPK4 17205132 1663883 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Positive_regulation CCND1 MAPK4 18321550 1919550 Progestin induction of [CCND1] was observed in cells expressing PR-B but not PR-BDeltaSH3 or PR-A and induction in the presence of PR-B was dramatically *reduced* in the presence of inhibitors of Src or . Positive_regulation CCND1 MAPK4 18640102 1947667 Enantioselective effect of 12 ( S ) -hydroxyeicosatetraenoic acid on 3T6 fibroblast growth through ERK 1/2 and p38 pathways and [cyclin D1] *activation* . Positive_regulation CCND1 MAPK4 18692155 2020174 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to dependent *activation* of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Positive_regulation CCND1 MAPK4 19589865 2137077 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of [CCND1] , but not cAMP up-regulation of IGFBP1 , in hESF of women with vs. without endometriosis . Positive_regulation CCND1 MAPK4 22611193 2610361 Cell cycle quiescence is associated with down-regulation of [cyclin D1] , up-regulation of the cyclin dependent kinase inhibitors , p21 ( cip1. ) and p16(INK4a) , and Forkhead transcriptional factor 1 ( Foxo1 ) , and *activation* of p38 , indicating that H-Cx43-deficient HSCs are prone to senescence . Positive_regulation CCND1 MAPK4 7559524 323597 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized *dependent* induction of [cyclin D1] promoter activity . Positive_regulation CCND1 MAPK4 9537433 497583 In conclusion , these findings suggest that MAPK/ERK activation in human HCC may play an important role in multistep hepatocarcinogenesis , especially in the progression of HCC; at least in part , through [cyclin D1] up-regulation primarily *induced* by via c-Fos . Positive_regulation CCND1 MAPK6 10082542 598296 Enforced long-term activation of p42/p44 by expression of the chimera DeltaRaf-1 : ER , which activates the p42/p44 MAPK cascade at the level of Raf , *enhanced* the expression of MKP1/2 and [cyclin D1] and , more importantly , restored the reentry of confluent cells into the cell cycle . Positive_regulation CCND1 MAPK6 11004713 734984 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping activation and c-Fos and [cyclin D1] *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation CCND1 MAPK6 11497244 846498 Activation of is *essential* for [cyclin D1] expression and provides a link between mitogenic signalling and cell cycle progression . Positive_regulation CCND1 MAPK6 12054565 951167 PD098059 and U0126 , two kinase inhibitors , and LY294002 , a PI3K inhibitor , significantly *blocked* thrombin induced [ ( 3 ) H ] thymidine incorporation and [cyclin D(1)] expression in ASM cells . Positive_regulation CCND1 MAPK6 12242655 990015 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Positive_regulation CCND1 MAPK6 12614329 1065162 In cultures treated with EGF , LY341495 was also able to reduce the stimulation of the pathway , as well as the *induction* of [cyclin D1] . Positive_regulation CCND1 MAPK6 12654183 1072974 may *induce* overexpression of [cyclin D1] protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation CCND1 MAPK6 12763029 1093781 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Positive_regulation CCND1 MAPK6 12816877 1134445 This overexpression inhibited PDGF induced expression of [cyclin D1] in the *presence* of unaffected activation . Positive_regulation CCND1 MAPK6 15095291 1238437 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Positive_regulation CCND1 MAPK6 15634644 1349544 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 , and down-regulation of [cyclin D1] . Positive_regulation CCND1 MAPK6 17205132 1663884 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Positive_regulation CCND1 MAPK6 18321550 1919551 Progestin induction of [CCND1] was observed in cells expressing PR-B but not PR-BDeltaSH3 or PR-A and induction in the presence of PR-B was dramatically *reduced* in the presence of inhibitors of Src or . Positive_regulation CCND1 MAPK6 18640102 1947668 Enantioselective effect of 12 ( S ) -hydroxyeicosatetraenoic acid on 3T6 fibroblast growth through ERK 1/2 and p38 pathways and [cyclin D1] *activation* . Positive_regulation CCND1 MAPK6 18692155 2020175 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to *dependent* activation of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Positive_regulation CCND1 MAPK6 19589865 2137078 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of [CCND1] , but not cAMP up-regulation of IGFBP1 , in hESF of women with vs. without endometriosis . Positive_regulation CCND1 MAPK6 22611193 2610362 Cell cycle quiescence is associated with down-regulation of [cyclin D1] , up-regulation of the cyclin dependent kinase inhibitors , p21 ( cip1. ) and p16(INK4a) , and Forkhead transcriptional factor 1 ( Foxo1 ) , and *activation* of p38 , indicating that H-Cx43-deficient HSCs are prone to senescence . Positive_regulation CCND1 MAPK6 7559524 323598 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized dependent *induction* of [cyclin D1] promoter activity . Positive_regulation CCND1 MAPK6 9537433 497584 In conclusion , these findings suggest that MAPK/ERK activation in human HCC may play an important role in multistep hepatocarcinogenesis , especially in the progression of HCC; at least in part , through [cyclin D1] up-regulation primarily *induced* by via c-Fos . Positive_regulation CCND1 MAPK7 10082542 598297 Enforced long-term activation of p42/p44 by expression of the chimera DeltaRaf-1 : ER , which activates the p42/p44 MAPK cascade at the level of Raf , *enhanced* the expression of MKP1/2 and [cyclin D1] and , more importantly , restored the reentry of confluent cells into the cell cycle . Positive_regulation CCND1 MAPK7 11004713 734985 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping activation and c-Fos and [cyclin D1] *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation CCND1 MAPK7 11497244 846499 Activation of is *essential* for [cyclin D1] expression and provides a link between mitogenic signalling and cell cycle progression . Positive_regulation CCND1 MAPK7 12054565 951168 PD098059 and U0126 , two kinase inhibitors , and LY294002 , a PI3K inhibitor , significantly *blocked* thrombin induced [ ( 3 ) H ] thymidine incorporation and [cyclin D(1)] expression in ASM cells . Positive_regulation CCND1 MAPK7 12242655 990016 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Positive_regulation CCND1 MAPK7 12614329 1065163 In cultures treated with EGF , LY341495 was also able to reduce the stimulation of the pathway , as well as the *induction* of [cyclin D1] . Positive_regulation CCND1 MAPK7 12654183 1072975 may *induce* overexpression of [cyclin D1] protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation CCND1 MAPK7 12763029 1093782 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Positive_regulation CCND1 MAPK7 12816877 1134446 This overexpression inhibited PDGF induced expression of [cyclin D1] in the *presence* of unaffected activation . Positive_regulation CCND1 MAPK7 15095291 1238438 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Positive_regulation CCND1 MAPK7 15634644 1349545 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 , and down-regulation of [cyclin D1] . Positive_regulation CCND1 MAPK7 17205132 1663885 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Positive_regulation CCND1 MAPK7 18321550 1919552 Progestin induction of [CCND1] was observed in cells expressing PR-B but not PR-BDeltaSH3 or PR-A and induction in the presence of PR-B was dramatically *reduced* in the presence of inhibitors of Src or . Positive_regulation CCND1 MAPK7 18640102 1947669 Enantioselective effect of 12 ( S ) -hydroxyeicosatetraenoic acid on 3T6 fibroblast growth through ERK 1/2 and p38 pathways and [cyclin D1] *activation* . Positive_regulation CCND1 MAPK7 18692155 2020176 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to dependent *activation* of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Positive_regulation CCND1 MAPK7 19589865 2137079 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of [CCND1] , but not cAMP up-regulation of IGFBP1 , in hESF of women with vs. without endometriosis . Positive_regulation CCND1 MAPK7 22286747 2586290 Inhibition of phosphorylation *attenuated* the increased expression of AP-1 and [cyclin D1] and cell proliferation induced by cyclic fluid flow , but promoted p-16 expression . Positive_regulation CCND1 MAPK7 22611193 2610363 Cell cycle quiescence is associated with down-regulation of [cyclin D1] , up-regulation of the cyclin dependent kinase inhibitors , p21 ( cip1. ) and p16(INK4a) , and Forkhead transcriptional factor 1 ( Foxo1 ) , and *activation* of p38 , indicating that H-Cx43-deficient HSCs are prone to senescence . Positive_regulation CCND1 MAPK7 7559524 323599 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized *dependent* induction of [cyclin D1] promoter activity . Positive_regulation CCND1 MAPK7 9537433 497585 In conclusion , these findings suggest that MAPK/ERK activation in human HCC may play an important role in multistep hepatocarcinogenesis , especially in the progression of HCC; at least in part , through [cyclin D1] up-regulation primarily *induced* by via c-Fos . Positive_regulation CCND1 MAPK8 10082542 598298 Enforced long-term activation of p42/p44 by expression of the chimera DeltaRaf-1 : ER , which activates the p42/p44 MAPK cascade at the level of Raf , *enhanced* the expression of MKP1/2 and [cyclin D1] and , more importantly , restored the reentry of confluent cells into the cell cycle . Positive_regulation CCND1 MAPK8 11004713 734986 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping activation and c-Fos and [cyclin D1] *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation CCND1 MAPK8 11497244 846500 Activation of is *essential* for [cyclin D1] expression and provides a link between mitogenic signalling and cell cycle progression . Positive_regulation CCND1 MAPK8 12054565 951169 PD098059 and U0126 , two kinase inhibitors , and LY294002 , a PI3K inhibitor , significantly *blocked* thrombin induced [ ( 3 ) H ] thymidine incorporation and [cyclin D(1)] expression in ASM cells . Positive_regulation CCND1 MAPK8 12242655 990017 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Positive_regulation CCND1 MAPK8 12614329 1065164 In cultures treated with EGF , LY341495 was also able to reduce the stimulation of the pathway , as well as the *induction* of [cyclin D1] . Positive_regulation CCND1 MAPK8 12654183 1072976 may *induce* overexpression of [cyclin D1] protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation CCND1 MAPK8 12763029 1093783 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Positive_regulation CCND1 MAPK8 12816877 1134447 This overexpression inhibited PDGF induced expression of [cyclin D1] in the *presence* of unaffected activation . Positive_regulation CCND1 MAPK8 15095291 1238439 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Positive_regulation CCND1 MAPK8 15634644 1349546 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 , and down-regulation of [cyclin D1] . Positive_regulation CCND1 MAPK8 17055752 1683907 The data showed overexpression of [cyclin D1] and increased expression and *activation* of ERK1/2 , p38 kinase and with progression of tumor suggesting that MAP kinases play an important role during tumorigenesis . Positive_regulation CCND1 MAPK8 17205132 1663886 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Positive_regulation CCND1 MAPK8 18321550 1919553 Progestin induction of [CCND1] was observed in cells expressing PR-B but not PR-BDeltaSH3 or PR-A and induction in the presence of PR-B was dramatically *reduced* in the presence of inhibitors of Src or . Positive_regulation CCND1 MAPK8 18640102 1947670 Enantioselective effect of 12 ( S ) -hydroxyeicosatetraenoic acid on 3T6 fibroblast growth through ERK 1/2 and p38 pathways and [cyclin D1] *activation* . Positive_regulation CCND1 MAPK8 18692155 2020177 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to *dependent* activation of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Positive_regulation CCND1 MAPK8 19589865 2137080 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of [CCND1] , but not cAMP up-regulation of IGFBP1 , in hESF of women with vs. without endometriosis . Positive_regulation CCND1 MAPK8 21726611 2471470 *Up-regulation* of [cyclin D1] by is involved in tumorigenesis of human embryo lung fibroblast cells induced by a low concentration of arsenite . Positive_regulation CCND1 MAPK8 22611193 2610364 Cell cycle quiescence is associated with down-regulation of [cyclin D1] , up-regulation of the cyclin dependent kinase inhibitors , p21 ( cip1. ) and p16(INK4a) , and Forkhead transcriptional factor 1 ( Foxo1 ) , and *activation* of p38 , indicating that H-Cx43-deficient HSCs are prone to senescence . Positive_regulation CCND1 MAPK8 7559524 323600 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized dependent *induction* of [cyclin D1] promoter activity . Positive_regulation CCND1 MAPK8 9537433 497586 In conclusion , these findings suggest that MAPK/ERK activation in human HCC may play an important role in multistep hepatocarcinogenesis , especially in the progression of HCC; at least in part , through [cyclin D1] up-regulation primarily *induced* by via c-Fos . Positive_regulation CCND1 MAPK9 10082542 598299 Enforced long-term activation of p42/p44 by expression of the chimera DeltaRaf-1 : ER , which activates the p42/p44 MAPK cascade at the level of Raf , *enhanced* the expression of MKP1/2 and [cyclin D1] and , more importantly , restored the reentry of confluent cells into the cell cycle . Positive_regulation CCND1 MAPK9 11004713 734987 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping activation and c-Fos and [cyclin D1] *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation CCND1 MAPK9 11497244 846501 Activation of is *essential* for [cyclin D1] expression and provides a link between mitogenic signalling and cell cycle progression . Positive_regulation CCND1 MAPK9 12054565 951170 PD098059 and U0126 , two kinase inhibitors , and LY294002 , a PI3K inhibitor , significantly *blocked* thrombin induced [ ( 3 ) H ] thymidine incorporation and [cyclin D(1)] expression in ASM cells . Positive_regulation CCND1 MAPK9 12242655 990018 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Positive_regulation CCND1 MAPK9 12614329 1065165 In cultures treated with EGF , LY341495 was also able to reduce the stimulation of the pathway , as well as the *induction* of [cyclin D1] . Positive_regulation CCND1 MAPK9 12654183 1072977 may *induce* overexpression of [cyclin D1] protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation CCND1 MAPK9 12763029 1093784 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Positive_regulation CCND1 MAPK9 12816877 1134448 This overexpression inhibited PDGF induced expression of [cyclin D1] in the *presence* of unaffected activation . Positive_regulation CCND1 MAPK9 15095291 1238440 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Positive_regulation CCND1 MAPK9 15634644 1349547 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 , and down-regulation of [cyclin D1] . Positive_regulation CCND1 MAPK9 17205132 1663887 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Positive_regulation CCND1 MAPK9 18321550 1919554 Progestin induction of [CCND1] was observed in cells expressing PR-B but not PR-BDeltaSH3 or PR-A and induction in the presence of PR-B was dramatically *reduced* in the presence of inhibitors of Src or . Positive_regulation CCND1 MAPK9 18640102 1947671 Enantioselective effect of 12 ( S ) -hydroxyeicosatetraenoic acid on 3T6 fibroblast growth through ERK 1/2 and p38 pathways and [cyclin D1] *activation* . Positive_regulation CCND1 MAPK9 18692155 2020178 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to *dependent* activation of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Positive_regulation CCND1 MAPK9 19589865 2137081 The kinase-1/2 inhibitor , U0126 , fully *restored* cAMP down-regulation of [CCND1] , but not cAMP up-regulation of IGFBP1 , in hESF of women with vs. without endometriosis . Positive_regulation CCND1 MAPK9 22611193 2610365 Cell cycle quiescence is associated with down-regulation of [cyclin D1] , up-regulation of the cyclin dependent kinase inhibitors , p21 ( cip1. ) and p16(INK4a) , and Forkhead transcriptional factor 1 ( Foxo1 ) , and *activation* of p38 , indicating that H-Cx43-deficient HSCs are prone to senescence . Positive_regulation CCND1 MAPK9 7559524 323601 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized *dependent* induction of [cyclin D1] promoter activity . Positive_regulation CCND1 MAPK9 9537433 497587 In conclusion , these findings suggest that MAPK/ERK activation in human HCC may play an important role in multistep hepatocarcinogenesis , especially in the progression of HCC; at least in part , through [cyclin D1] up-regulation primarily *induced* by via c-Fos . Positive_regulation CCND1 MAX 19086036 2041962 Switch from Mnt-Max to *induces* p53 and [cyclin D1] expression and apoptosis during cholestasis in mouse and human hepatocytes . Positive_regulation CCND1 ME2 15691880 1371471 <2-ME2> *had* no significant effect on [cyclin D1] ; Positive_regulation CCND1 MEAF6 18399550 1893740 Overexpression of can induce growth inhibition in A549 cells both in vitro and in vivo , and also *induce* up-regulation of p27 , down-regulation of [cyclinD1] , SKP2 , and Cox2 , and inactivation of the Wnt-1/beta-catenin pathway . Positive_regulation CCND1 MEAF6 19430401 2077850 Overexpression of could induce growth suppression and apoptosis enhancement in M14 cells , and also *induce* the upregulation of p27 , Bax and Cyt-c , and the downregulation of [cyclinD1] , SKP2 , Bcl-2 , and caspase-3 . Positive_regulation CCND1 MECOM 16462766 1567551 Likewise , did not *inhibit* TGFbeta mediated downregulation of [cyclin D1] or block TGFbeta mediated growth inhibition . Positive_regulation CCND1 MED1 21928377 2539200 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED10 21928377 2539195 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED11 21928377 2539198 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED13 21928377 2539182 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED13L 21928377 2539183 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED14 21928377 2539187 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED15 21928377 2539176 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED16 21928377 2539178 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED17 21928377 2539189 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED18 21928377 2539194 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED19 21928377 2539197 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED20 21928377 2539177 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED21 21928377 2539174 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED22 21928377 2539175 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED23 21928377 2539188 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED24 21928377 2539184 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED25 21928377 2539196 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED26 21928377 2539190 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED27 21928377 2539191 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED29 21928377 2539186 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED30 21928377 2539185 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED31 21928377 2539193 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED4 21928377 2539179 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED6 21928377 2539180 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED7 21928377 2539192 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MED8 21928377 2539181 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 MIF 12297513 1034765 Adhesion mediated release of subsequently *promotes* integrin dependent activation of MAP kinase , [cyclin D1] expression , and DNA synthesis . Positive_regulation CCND1 MIF 15840582 1418282 Rho GTPase dependent signaling is required for *mediated* expression of [cyclin D1] . Positive_regulation CCND1 MIF 15840582 1418283 We now report that *promotes* the activation of the canonical ERK MAPK cascade and [cyclin D1] expression by stimulating the activity of the Rho GTPase and downstream signaling to stress fiber formation . Positive_regulation CCND1 MIF 15840582 1418286 Our studies reveal that recombinant *induces* [cyclin D1] expression in a Rho- , Rho kinase- , MLC kinase- , and ERK dependent manner in asynchronous NIH 3T3 fibroblasts . Positive_regulation CCND1 MIR193B 20304954 2254852 represses cell proliferation and *regulates* [cyclin D1] in melanoma . Positive_regulation CCND1 MIR19A 20133739 2213546 *mediates* the suppressive effect of laminar flow on [cyclin D1] expression in human umbilical vein endothelial cells . Positive_regulation CCND1 MIR200B 20683643 2329484 *regulates* [cyclin D1] expression and promotes S-phase entry by targeting RND3 in HeLa cells . Positive_regulation CCND1 MNT 19086036 2041978 Lowering expression further *enhanced* LCA 's inductive effect on p53 and [cyclin D1] . Positive_regulation CCND1 MOCOS 9083291 420986 PDGF stimulation of *induced* protein expression of the G1 phase [cyclin D1] as well as the cyclin dependent kinases cdk 4 and cdk 2 . Positive_regulation CCND1 MSTN 17130121 1693422 *induces* [cyclin D1] degradation to cause cell cycle arrest through a phosphatidylinositol 3-kinase/AKT/GSK-3 beta pathway and is antagonized by insulin-like growth factor 1 . Positive_regulation CCND1 MSTN 17130121 1693424 We further showed that phosphorylation at threonine 286 by GSK-3beta was required for *stimulated* [cyclin D1] nuclear export and degradation . Positive_regulation CCND1 MSTN 17130121 1693428 Insulin-like growth factor 1 (IGF-1) treatment or Akt activation attenuated the *stimulated* [cyclin D1] degradation as well as the associated cell proliferation repression . Positive_regulation CCND1 MSX2 20394734 2255830 In this study , we show that overexpression of transiently *suppressed* the expression of [Cyclin D1] and blocked cell proliferation . Positive_regulation CCND1 MT1JP 12111702 963531 Androgen-sensitive prostate cancer cell proliferation may be modulated by opposite changes in [cyclin D1] levels *induced* by activated and EGF receptors . Positive_regulation CCND1 MTA1 21595884 2441545 Down-regulation of by RNAi approach led to re-expression of ER alpha in ER-negative breast cancer cell lines MDA-MB-231 , and *reduced* protein levels of MMP-9 and [CyclinD1] , as well as decreased tumor cell invasion and proliferation , more cells were blocked in G0/G1 stage ( P < 0.05 ) . Positive_regulation CCND1 MTDH 19304953 2064351 Moreover , we demonstrated that the upregulation of could reduce the expression of p27 ( Kip1 ) and *induce* the expression of [cyclin D1] through the AKT/FOXO3a pathway . Positive_regulation CCND1 MTOR 17210710 1681531 Critical components in the translational machinery , such as phosphorylated mammalian target of rapamycin (mTOR) and its downstream targets , phosphorylated eukaryotic translation initiation factor and p70 S6 kinase , were up-regulated following NO treatment , and inhibition of with rapamycin *attenuated* NO induced increase of [cyclin D1] and ODC . Positive_regulation CCND1 MTOR 18026138 1894610 Importantly , inhibitors *induced* downregulation of vascular endothelial growth factor A ( VEGF-A ) secretion , [cyclin D1] and MYCN protein expression in vitro and in vivo . Positive_regulation CCND1 MTOR 21135252 2377988 AP-1 regulates [cyclin D1] and c-MYC transcription in an AKT dependent manner in *response* to inhibition : role of AIP4/Itch mediated JUNB degradation . Positive_regulation CCND1 MTOR 24583924 2942667 Inhibition of activity *led* to downregulation of [cyclin D1] , a gene regulated by messenger RNA translation via phosphorylation of 4E-BP1 . Positive_regulation CCND1 MTOR 24626091 2934215 Mechanistic investigations showed that kinase inhibitors *reduced* [cyclin D1] levels in a GSK3ß dependent manner , independent of their effects on suppressing mTORC1 signaling and cap binding . Positive_regulation CCND1 MUC1 14688481 1179632 We also show that transcription of the Wnt responsive [cyclin D1] promoter is *activated* by , but not MUC1 ( Y46F ) , and that the cyclin D1 gene is upregulated in MUC1 positive cells . Positive_regulation CCND1 MUC1 22318732 2571529 In addition , a inhibitor blocked the interaction with TCF7L2 and *suppressed* [cyclin D1] levels . Positive_regulation CCND1 MUC1 24979278 2947635 *regulates* [cyclin D1] gene expression through p120 catenin and ß-catenin . Positive_regulation CCND1 MYBL2 15922873 1413859 Previous work has suggested that the [cyclin D1] gene might be *regulated* by . Positive_regulation CCND1 MYC 12790780 1097548 An antisense mediated decrease in expression *results* in decreased [cyclin D1] expression and inhibition of DNA synthesis , mimicking the effects of antiestrogen treatment and emphasizing the importance of c-Myc as an estrogen/antiestrogen target . Positive_regulation CCND1 MYC 19086036 2041963 Switch from Mnt-Max to *induces* p53 and [cyclin D1] expression and apoptosis during cholestasis in mouse and human hepatocytes . Positive_regulation CCND1 MYC 22190866 2518564 [Cyclin D1] inhibits whereas *enhances* the cytotoxicity of cisplatin in mouse pancreatic cancer cells via regulation of several members of the NF-?B and Bcl-2 families . Positive_regulation CCND1 MYC 23975033 2920856 Emodin ( 72 h ) treatment could up-regulate the gene expression of FASL ( p < 0.05 ) and down-regulate the gene expression of ( p < 0.01 ) , but *induce* no significant changes in the gene expressions of MCL1 , GAPDH , BAX and [CCND1] . Positive_regulation CCND1 MYC 7588611 329977 We now report that induction of in density arrested fibroblasts *triggers* rapid hyperphosphorylation of the retinoblastoma protein and activation of both [cyclin D1-] and cyclin E-associated kinase activities in the absence of significant changes in the amounts of cyclin-cdk complexes . Positive_regulation CCND1 MYLIP 18483394 1939096 This study introduces the *role* of in the regulation of [CCND1] in MCL . Positive_regulation CCND1 MYLIP 18710938 1968185 The transcriptional *activation* of and the translational repression of its targets , such as [cyclin D1] , may provide a link between Oct4/Sox2 and cell cycle regulation in pluripotent cells . Positive_regulation CCND1 MYLIP 19703993 2144610 Downregulation of in meningiomas and arachnoidal cells *resulted* in increased expression of beta-catenin and [cyclin D1] involved in cell proliferation . Positive_regulation CCND1 MYLIP 20304954 2254854 A luciferase reporter assay confirmed that directly *regulates* [CCND1] by binding to the 3'untranslated region of CCND1 mRNA . Positive_regulation CCND1 MYLIP 20304954 2254856 These studies indicate that represses cell proliferation and *regulates* [CCND1] expression and suggest that dysregulation of miR-193b may play an important role in melanoma development . Positive_regulation CCND1 MYLIP 21893020 2496532 In a previous study , we reported that represses cell proliferation and *regulates* [cyclin D1] in melanoma cells , suggesting that miR-193b could act as a tumor suppressor . Positive_regulation CCND1 MYLIP 22610915 2691415 Up-regulated *resulted* in nuclear accumulation of ß-catenin and a concomitant increase in [cyclin D1] , c-myc , and survivin . Positive_regulation CCND1 MYLIP 22858023 2671529 Overexpression of in HTR-8/SVneo cells *reduced* the level of [cyclin D1] protein , decreased cell proliferation and invasion , and increased cell number at the G1 stage . Positive_regulation CCND1 MYLIP 22912826 2657483 can directly *regulate* [CyclinD1] expression through binding to the CyclinD1-3'UTR region , mainly at nt 2397-2403 . Positive_regulation CCND1 MYLIP 23060044 2763560 Moreover , overexpression in prostate cancer cells *increased* the G1/S transitional promoter , [cyclin D1] expression , and decreased cyclin dependent kinase (CDK) inhibitor , p21 ( Cip1 ) expression . Positive_regulation CCND1 MYLIP 23284982 2711684 Further , the overexpression of increased TP53 expression but *reduced* SMAD2 , and [CCND1] expression levels . Positive_regulation CCND1 MYLIP 23451060 2749367 Overexpression of inhibited cell cycle progression , promoted apoptosis , and *reduced* [Cyclin D1] and Bcl-2 expression in two TSCC cell lines . Positive_regulation CCND1 MYLIP 23991964 2836649 At the molecular level , our results further revealed that [cyclin D1] expression was negatively *regulated* by . Positive_regulation CCND1 MYLIP 24107628 2878892 We demonstrate that , either exogenous or endogenous , reduces cyclin D1 levels and proliferation rate in C2C12 cells without promoting differentiation , and that miR-206 knockdown in terminally differentiated C2C12 cells *leads* to [cyclin D1] accumulation in myotubes , indicating that miR-206 might be involved in the maintenance of the post-mitotic state . Positive_regulation CCND1 MYLIP 25111862 2954407 Finally , we demonstrate that [cyclin D1] is *regulated* by in PrEC but not in PCa cells and this is due to the absence of a CCND1 3'-UTR in these cells . Positive_regulation CCND1 NCK1 21719533 2471260 *regulates* [cyclin D1] promoter activity in response to prolactin . Positive_regulation CCND1 NCOA1 22542550 2631164 We studied the *role* of PR and in the expression of VEGF , EGFR and [cyclin D1] mediated by P in human astrocytoma cell lines grade III ( U373 ) and IV ( D54 ) . Positive_regulation CCND1 NCOA3 11358796 816111 *enhances* estrogen dependent induction of [cyclin D1] expression . Positive_regulation CCND1 NCOR1 18632669 1959970 Overexpression of SMRT and *attenuated* the transcription of beta-catenin-TCF4-specific reporter gene and of [CCND1] , an endogenous beta-catenin target gene . Positive_regulation CCND1 NCOR2 17591692 1779290 is *required* for full expression of the ERalpha target genes [cyclin D1] , BCL-2 , and progesterone receptor but not pS2 , and its depletion significantly attenuated estrogen dependent proliferation of MCF-7 cells . Positive_regulation CCND1 NCOR2 18632669 1959971 Overexpression of and NCoR *attenuated* the transcription of beta-catenin-TCF4-specific reporter gene and of [CCND1] , an endogenous beta-catenin target gene . Positive_regulation CCND1 NCOR2 21901538 2521950 We also found that when down regulation of p65 , the expression of [cyclin D1] and Bc1-2 decreased , and the expression of *increased* in vitro and vivo . Positive_regulation CCND1 NELFCD 20735431 2324063 Moreover , upregulation of in MDA-MB-231 cells *resulted* in the decrease of [cyclin D1] , ß-catenin , and ERK activity , and the increase of p21 . Positive_regulation CCND1 NFATC1 23737530 2819872 MCP1 induced [cyclin D1] expression as well as CDK6 and CDK4 activities , and these effects were *dependent* on activation of . Positive_regulation CCND1 NFATC4 16645724 1583382 These results indicate that ionizing radiation is able to enhance cyclin D1 transcription induced by B [ a ] PDE , and is *involved* in the regulation of [cyclin D1] transcription by B [ a ] PDE or B [ a ] PDE plus ionizing radiation . Positive_regulation CCND1 NFKB1 10082535 597786 Moreover , inhibition of *caused* a pronounced reduction of serum induced [cyclin D1-associated] kinase activity and resulted in delayed phosphorylation of the retinoblastoma protein . Positive_regulation CCND1 NFKB1 10409765 630551 An analysis of cell cycle markers revealed that *activates* [cyclin D1] expression , and the results showed that this regulatory pathway is one mechanism by which NF-kappaB inhibits myogenesis . Positive_regulation CCND1 NFKB1 10409765 630553 NF-kappaB regulation of [cyclin D1] occurs at the transcriptional level and is *mediated* by direct binding of to multiple sites in the cyclin D1 promoter . Positive_regulation CCND1 NFKB1 10409765 630559 Using diploid fibroblasts , we demonstrate that is *required* to induce [cyclin D1] expression and pRb hyperphosphorylation and promote G ( 1 ) -to-S progression . Positive_regulation CCND1 NFKB1 10464245 640342 Induction of [cyclin D1] by Rac1 *required* both an and an ATF-2 binding site . Positive_regulation CCND1 NFKB1 11027278 738766 Here we show that expression of activated Ral in quiescent rodent fibroblasts is sufficient to induce activation of *dependent* gene expression and [cyclin D1] transcription , two key convergence points for mitogenic and survival signaling . Positive_regulation CCND1 NFKB1 11027278 738771 The regulation of [cyclin D1] transcription by Ral is *dependent* on activation and is mediated through an NF-kappaB binding site in the cyclin D1 promoter . Positive_regulation CCND1 NFKB1 11747812 889406 IKKalpha and activation are also *required* for optimal [cyclin D1] induction . Positive_regulation CCND1 NFKB1 11861406 917203 Expressions of Cyclin B1 , [Cyclin D1] , and HIAP were *down-regulated* by the inhibition of . Positive_regulation CCND1 NFKB1 11992406 938696 Inhibitors of ( dominant negative IkappaBs mutants ) *suppressed* Tax dependent activation of [cyclin D1] and D2 promoters , indicating that Tax induced activation was mediated by NF-kappaB . Positive_regulation CCND1 NFKB1 12907607 1119204 The inhibition of NF-kappaB activation correlated with suppression of *dependent* [cyclin D1] , cyclooxygenase 2 , and matrix metalloproteinase 9 expression . Positive_regulation CCND1 NFKB1 1431100 202783 We also show by antibody-depletion that *activates* the [BCL1] promoter in vitro . Positive_regulation CCND1 NFKB1 15131058 1245554 The inhibition of activation correlated with a decreased expression of NF-kappaB dependent reporter gene and *suppressed* expression of NF-kappaB regulated genes [ specifically , Bcl2 , [cyclin D1] , cyclooxygenase-2 , matrix metalloproteinase 9 , nitric oxide synthase-2 (NOS-2) , and vascular endothelial growth factor ] . Positive_regulation CCND1 NFKB1 15798085 1451616 Moreover , inhibition of *caused* a pronounced reduction of EGF induced [cyclin D1] promoter activity . Positive_regulation CCND1 NFKB1 15893541 1407600 To determine whether the NNK induced activation and [cyclin D1] *induction* were also observed in vivo , A/J mice were treated with NNK ( 9.1 mg ) for 20 weeks and the results showed a significant induction of cyclin D1 and NFkappaB translocation determined by immunoblotting analyses . Positive_regulation CCND1 NFKB1 16230390 1470077 The induction of [cyclin D1] by arsenite *required* activation , because the inhibition of IkappaB phosphorylation by overexpression of the dominant negative mutant , IKKbeta-KM , impaired arsenite induced cyclin D1 expression and G1-S transition . Positive_regulation CCND1 NFKB1 16231352 1476743 The underlying molecular mechanism was associated with increased inhibitor of nuclear factor-kappa B alpha ( IkappaBalpha ) expression , which inhibited activation and *induction* of its target genes , [cyclin D1] and Bcl-xL , increasing sensitivity to apoptosis initiated by elevated tumor necrosis factor-alpha . Positive_regulation CCND1 NFKB1 16322332 1487936 Although TNFalpha was poorly effective in increasing cyclin D1 expression , blockade by the specific inhibitor BAY11-7082 *reduced* FCS stimulated [cyclin D1] by about 60 % . Positive_regulation CCND1 NFKB1 16331275 1526284 We have found that TNF-alpha exerts a mitogenic effect , inducing [cyclin D1] expression and *activation* of the transcription factor . Positive_regulation CCND1 NFKB1 16331275 1526286 Importantly , activation of was *required* for estrogen induced proliferation and [cyclin D1] expression . Positive_regulation CCND1 NFKB1 16481354 1528467 We show that activation is *essential* for induction of Shh and [cyclin D1] expression and subsequent placode down growth . Positive_regulation CCND1 NFKB1 16759223 1631481 AP1 and cAMP response element ( CRE ) , but not , were *involved* in the induced [cyclin D1] expression . Positive_regulation CCND1 NFKB1 16940298 1627451 Up-regulation of [cyclin D1] by HBx is *mediated* by complex through kappaB site of cyclin D1 promoter . Positive_regulation CCND1 NFKB1 16963181 1700238 Furthermore , rugosin E also inhibited the TNF-alpha activated *dependent* reporter gene expression of [cyclin D1] , c-Myc , XIAP , Bcl-2 , and Bcl-X ( L ) were all downregulated by rugosin E . Positive_regulation CCND1 NFKB1 17385714 1727711 These findings suggest that activation *stimulates* [cyclin D1] expression and triggers DNA replication in striatal neurons . Positive_regulation CCND1 NFKB1 18160626 1869291 Consequently , the inhibition of Ca ( 2+ ) , PKC , EGFR , p44/42 MAPKs , or *blocked* the BSA induced increases in [cyclin D1] , cyclin dependent kinase (CDK)4 , cyclin E , or CDK2 and restored the BSA induced inhibition of p21 ( WAF/Cip1 ) and p27 ( Kip1 ) expression . Positive_regulation CCND1 NFKB1 19263436 2135397 In this article , we found that Degenerative Spermatocyte Homolog 1 ( DEGS1 ) up-regulated the expression of cyclin D1 and the activation of transcription factor was *essential* for DEGS1 induced [cyclin D1] production . Positive_regulation CCND1 NFKB1 19551842 2208793 This was associated with significantly lower proliferating cell nuclear antigen positive hepatocytes and [cyclinD1] protein , as well as decreased *activation* of extracellular signal regulated kinase and nuclear . Positive_regulation CCND1 NGF 16611639 1568867 Furthermore , reduced STAT3 expression in PC12 cells suppressed *induced* [cyclin D1] expression , thereby inhibiting growth arrest normally triggered by NGF treatment . Positive_regulation CCND1 NGF 17404514 1735987 Both and BDNF *increase* the expression of [cyclin D1] and cyclin dependent kinase 4 (cdk4) , with temporal expression patterns that parallel the proliferation kinetics of their cellular targets . Positive_regulation CCND1 NGF 18367547 1912794 Herein , *induced* [cyclin D1] promoter , mRNA , and protein expression via the p21 ( RAS ) pathway . Positive_regulation CCND1 NGF 18367547 1912795 Expression vectors encoding mutants of the Ras/mitogen activated protein kinase pathway , and chemical inhibitors , demonstrated *induction* of [cyclin D1] involved cooperative interactions of extracellular signal regulated kinase , p38 , and phosphatidylinositol 3-kinase pathways downstream of p21 ( RAS ) . Positive_regulation CCND1 NGF 18367547 1912796 *induced* the [cyclin D1] promoter via Sp1 , nuclear factor-kappaB , and cAMP-response element/activated transcription factor sites . Positive_regulation CCND1 NGF 23743199 2807090 The data from PLCs and ILCs showed that could *increase* [Cyclin D1] and Hsd 17b3 mRNA levels in PLCs and Cyclin D1 mRNA levels in ILCs . Positive_regulation CCND1 NGF 7666202 322122 These results indicate that *induction* of [cyclin D1] and inactivation of cdk kinases , the latter possibly by increase of p21 , play a central role in the NGF block of PC12 cell cycling . Positive_regulation CCND1 NGF 9236224 445597 *induces* transcription of the p21 WAF1/CIP1 and [cyclin D1] genes in PC12 cells by activating the Sp1 transcription factor . Positive_regulation CCND1 NGF 9236224 445601 We have shown previously ( ) that *induces* the expression of the p21 WAF1/CIP1/Sdi1 ( p21 ) cyclin dependent kinase (Cdk) inhibitor protein and the G1 phase cyclin , [cyclin D1] . Positive_regulation CCND1 NME2 22192927 2568788 In addition , NF-?B and [cyclin D1] expression were also *increased* by . Positive_regulation CCND1 NODAL 19688838 2157932 *activates* Smad2/3 phosphorylation , Oct-4 transcription , [cyclin D1] , and cyclin E expression , whereas SB431542 completely abolishes their increase . Positive_regulation CCND1 NOTCH1 11486031 845100 *Induction* of [cyclin D1] transcription and CDK2 activity by ( ic ) : implication for cell cycle disruption in transformation by Notch ( ic ) . Positive_regulation CCND1 NOTCH1 11486031 845108 Using this inducible system , we show that ( ic ) *activates* transcription of the [cyclin D1] gene with rapid kinetics . Positive_regulation CCND1 NOTCH1 11486031 845121 Upregulation of [cyclin D1] and *activation* of CDK2 by ( ic ) result in the promotion of S-phase entry . Positive_regulation CCND1 NOTCH1 16885355 1596316 To determine if *induced* [cyclin D1] expression in RKE-ER-N ( ic ) cells plays a direct role in transformation , cyclin D1 up-regulation was inhibited using a cyclin D1 antisense cDNA . Positive_regulation CCND1 NOTCH1 20443831 2009606 ErbB2 induced cyclin D1 and cyclin D1 expression was suficient to induce Notch1 activity , and conversely , genetic deletion of Notch1 in mammary epithelial cells using foxed Notch ( Notch ( fl/fl ) ) mice demonstrated that [cyclin D1] is *induced* by . Positive_regulation CCND1 NOTCH1 20887720 2343251 Activation of Notch signaling for 6h specifically at day 3 during neural induction in the ES cells led to significantly enhanced cell proliferation , accompanied by *mediated* activation of [cyclin D1] expression . Positive_regulation CCND1 NOTCH1 20887720 2343255 In conclusion , the data define a novel temporal context dependent function of and a critical *role* for [cyclin D1] in the Notch induced proliferation in ES cells . Positive_regulation CCND1 NOTCH2 11486031 845101 *Induction* of [cyclin D1] transcription and CDK2 activity by ( ic ) : implication for cell cycle disruption in transformation by Notch ( ic ) . Positive_regulation CCND1 NOTCH2 11486031 845109 Using this inducible system , we show that ( ic ) *activates* transcription of the [cyclin D1] gene with rapid kinetics . Positive_regulation CCND1 NOTCH2 11486031 845122 Upregulation of [cyclin D1] and *activation* of CDK2 by ( ic ) result in the promotion of S-phase entry . Positive_regulation CCND1 NOTCH2 20887720 2343252 Activation of Notch signaling for 6h specifically at day 3 during neural induction in the ES cells led to significantly enhanced cell proliferation , accompanied by mediated *activation* of [cyclin D1] expression . Positive_regulation CCND1 NOTCH2 20887720 2343256 In conclusion , the data define a novel temporal context dependent function of and a critical *role* for [cyclin D1] in the Notch induced proliferation in ES cells . Positive_regulation CCND1 NOTCH3 11486031 845102 *Induction* of [cyclin D1] transcription and CDK2 activity by ( ic ) : implication for cell cycle disruption in transformation by Notch ( ic ) . Positive_regulation CCND1 NOTCH3 11486031 845110 Using this inducible system , we show that ( ic ) *activates* transcription of the [cyclin D1] gene with rapid kinetics . Positive_regulation CCND1 NOTCH3 11486031 845123 Upregulation of [cyclin D1] and *activation* of CDK2 by ( ic ) result in the promotion of S-phase entry . Positive_regulation CCND1 NOTCH3 20887720 2343253 Activation of Notch signaling for 6h specifically at day 3 during neural induction in the ES cells led to significantly enhanced cell proliferation , accompanied by *mediated* activation of [cyclin D1] expression . Positive_regulation CCND1 NOTCH3 20887720 2343257 In conclusion , the data define a novel temporal context dependent function of and a critical *role* for [cyclin D1] in the Notch induced proliferation in ES cells . Positive_regulation CCND1 NOTCH3 23924696 2840624 Down-regulation of using small interfering RNA *inhibits* the expression of [Cyclin D1] and prevents apelin-13 induced VSMC proliferation . Positive_regulation CCND1 NOTCH4 11486031 845103 *Induction* of [cyclin D1] transcription and CDK2 activity by ( ic ) : implication for cell cycle disruption in transformation by Notch ( ic ) . Positive_regulation CCND1 NOTCH4 11486031 845111 Using this inducible system , we show that ( ic ) *activates* transcription of the [cyclin D1] gene with rapid kinetics . Positive_regulation CCND1 NOTCH4 11486031 845124 Upregulation of [cyclin D1] and *activation* of CDK2 by ( ic ) result in the promotion of S-phase entry . Positive_regulation CCND1 NOTCH4 20887720 2343254 Activation of Notch signaling for 6h specifically at day 3 during neural induction in the ES cells led to significantly enhanced cell proliferation , accompanied by mediated *activation* of [cyclin D1] expression . Positive_regulation CCND1 NOTCH4 20887720 2343258 In conclusion , the data define a novel temporal context dependent function of and a critical *role* for [cyclin D1] in the Notch induced proliferation in ES cells . Positive_regulation CCND1 NOX1 16987002 1617634 In cycling cells , the effects of Nox1 were dose dependent : levels of that induced 3- to 10-fold increases in ROS *promoted* phosphorylation of ERK1/2 and expression of [cyclin D1] , whereas expression of Nox1 with Noxo1 and Noxa1 ( or expression of Nox4 alone ) that induced substantial increases in intracellular ROS inhibited cyclin D1 and proliferation . Positive_regulation CCND1 NOX1 23864022 2817525 Genetic inactivation of Hace1 in mice or zebrafish , as well as Hace1 loss in human tumor cell lines or primary murine or human tumors , leads to chronic *dependent* reactive oxygen species elevation , DNA damage responses and enhanced [cyclin D1] expression . Positive_regulation CCND1 NOX3 23864022 2817526 Genetic inactivation of Hace1 in mice or zebrafish , as well as Hace1 loss in human tumor cell lines or primary murine or human tumors , leads to chronic *dependent* reactive oxygen species elevation , DNA damage responses and enhanced [cyclin D1] expression . Positive_regulation CCND1 NOX4 23864022 2817527 Genetic inactivation of Hace1 in mice or zebrafish , as well as Hace1 loss in human tumor cell lines or primary murine or human tumors , leads to chronic *dependent* reactive oxygen species elevation , DNA damage responses and enhanced [cyclin D1] expression . Positive_regulation CCND1 NOX5 23864022 2817524 Genetic inactivation of Hace1 in mice or zebrafish , as well as Hace1 loss in human tumor cell lines or primary murine or human tumors , leads to chronic *dependent* reactive oxygen species elevation , DNA damage responses and enhanced [cyclin D1] expression . Positive_regulation CCND1 NQO2 22266466 2564852 Our results indicate a hitherto unreported *role* of in the control of [AKT/GSK-3ß/cyclin D1] and highlight the involvement of NQO2 in degradation of cyclin D1 , as part of mechanism of chemoprevention by resveratrol . Positive_regulation CCND1 NR0B1 23118901 2696023 GLT treatment also significantly down-regulated *dependent* expression of [cyclin D1] , COX-2 , CYP1A2 and CYP3A4 in colon tissue . Positive_regulation CCND1 NR2F2 10772965 686323 Interestingly , *increased* the expression of [cyclin D1] and p21 ( WAF1/CIP1 ) in MDA-MB-435 cells . Positive_regulation CCND1 NR4A1 24047441 2902387 Overexpression of *inhibited* 5-HT induced PASMC proliferation , as well as the expression of [cyclin D1] and proliferating cell nuclear antigen . Positive_regulation CCND1 NR4A2 19570744 2129061 Further studies have revealed that may *mediate* [cyclin D1] expression and I-BOP induced cell proliferation in H157 cells since small interfering RNA of Nurr1 blocked I-BOP induced cyclin D1 expression and cell proliferation and also decreased cell growth rate . Positive_regulation CCND1 NR5A2 24333731 2910835 overexpression *enhanced* the expression of downstream target genes ( [cyclin D1/E1] ) and stimulated cell proliferation in PC cell lines . Positive_regulation CCND1 NRAS 10340949 616231 Finally , the synthetic MEK inhibitor PD98059 blocked *induced* [cyclin D1] promoter activity . Positive_regulation CCND1 NRAS 10531005 561996 By microinjecting anti-Ras antibody , we found that the induction of [cyclin D1] expression beginning in G2 phase was *dependent* on activity . Positive_regulation CCND1 NRAS 10531005 561999 *dependent* induction of [cyclin D1] expression beginning in G2 phase is critical for continuous cell cycle progression in NIH3T3 cells . Positive_regulation CCND1 NRAS 10611246 656159 Induction of [cyclin D1] by NeuT *involved* , Rac , Rho , extracellular signal regulated kinase , c-Jun N-terminal kinase , and p38 , but not phosphatidylinositol 3-kinase . Positive_regulation CCND1 NRAS 10698514 671846 As already reported , oncogenic expression was *sufficient* to induce [cyclin D1] and p21cip1 expression and their association with cdk4 . Positive_regulation CCND1 NRAS 11159909 781454 Activation of and Erk *causes* induction of [cyclin D1-Cdk4] without increase of cyclin E or PCNA in ductal lesions . Positive_regulation CCND1 NRAS 11223027 787809 Thus , activity during G2 phase *induces* [cyclin D1] expression . Positive_regulation CCND1 NRAS 12082537 958579 In exponentially growing cells , oncogenic *had* no effect on proliferation rates , Erk phosphorylation , or the level of [cyclin D1] , and Ras-induction did not confer serum independent growth . Positive_regulation CCND1 NRAS 12082537 958591 in this setting , induction *prevented* full downregulation of [cyclin D1] and inactivation of Erk . Positive_regulation CCND1 NRAS 12202534 983086 The requirement for and the regulatory *role* of ERK2 in [cyclin D1] production and in cell proliferation suggest that the Ras/Raf/MEK/ERK pathway plays a key role in the control of RPE cell proliferation . Positive_regulation CCND1 NRAS 12386817 999801 To understand the mechanism of the *dependent* [cyclin D1] induction , cyclin D1 mRNA levels were determined by quantitative image analysis following fluorescent in situ hybridization . Positive_regulation CCND1 NRAS 12429909 1015094 These studies were designed to understand how could *induce* [cyclin D1] levels only during G2 phase . Positive_regulation CCND1 NRAS 12429909 1015100 This suggests that [cyclin D1] induction during G2 phase is not the *result* of activation specifically during this cell cycle period . Positive_regulation CCND1 NRAS 12505306 1026998 The hormone also causes a decrease of cyclin D1 gene transcription , and is able to antagonize the *activation* of the [cyclin D1] promoter by . Positive_regulation CCND1 NRAS 12648671 1070445 The decision to continue cell cycle progression takes place in G2 phase , when cellular *induces* the elevation of [cyclin D1] levels . Positive_regulation CCND1 NRAS 12794085 1120076 Although Ras , Raf , and MEK all increased expression of cyclin D1 on collagen film , only and Raf significantly *up-regulated* [cyclin D1] levels on collagen gel . Positive_regulation CCND1 NRAS 14657670 1188536 PAK is essential for *induced* upregulation of [cyclin D1] during the G1 to S transition . Positive_regulation CCND1 NRAS 14657670 1188546 In this report , using two distinct inhibitors specific for PAK1-3 ( CEP-1347 and WR-PAK18 ) , we present the first evidence indicating that the PIX/Rac/CDC42 dependent Ser/Thr kinases PAK1-3 , acting downstream of PI-3 kinase and upstream of the Raf/MEK/ERKs kinase cascade , is essential for *induced* upregulation of [cyclin D1] , but not downregulation of p27 . Positive_regulation CCND1 NRAS 15675969 1366393 Taken together , these results suggest that CWF inhibits the growth of dermal fibroblasts at least in part by decreasing the level of active , resulting in decreased *levels* of ppRb and [cyclin D1] . Positive_regulation CCND1 NRAS 15958613 1422839 Inhibition of active by farnesylthiosalicylic acid *led* to attenuation of the Raf-MEK-ERK and phosphoinositide 3-kinase-Akt-glycogen synthase-3 ( GSK-3 ) pathways , to reduction in [cyclin D1] , phospho-retinoblastoma , and E2F , and to increase in the cyclin dependent kinase inhibitor p27 and in retinoblastoma binding protein-1 , an inhibitor of E2F transcriptional activity . Positive_regulation CCND1 NRAS 18604165 1935598 However , more recent reports suggested that the commitment to cycle in response to serum occurs already in G ( 2 ) phase and requires the dependent *induction* of [cyclin D1] , which promotes following G ( 1 ) /S transition . Positive_regulation CCND1 NRAS 20717927 2345722 In MIA PaCa-2 cells in culture , LOX-PP attenuated the ERK and AKT activities and decreased the levels of the NF-?B p65 and RelB subunits and [cyclin D1] , which are *activated* by signaling . Positive_regulation CCND1 NRAS 20798689 2368248 ASPP2 suppresses *induced* small ubiquitin-like modifier (SUMO) modified nuclear [cyclin D1] and inhibits retinoblastoma protein ( Rb ) phosphorylation . Positive_regulation CCND1 NRAS 9199319 438901 Analysis of Cdk-cyclin complexes indicates that signaling is *required* both for induction of [cyclin D1] and for downregulation of the Cdk inhibitor p27KIP1 . Positive_regulation CCND1 NRAS 9407076 470826 Overexpression of dominant negative forms of or RhoA completely blocked PDGF induced p27 ( KIP1 ) degradation , but only dominant negative Ras *inhibited* [cyclin D1] protein expression . Positive_regulation CCND1 NRD1 21769958 2467173 Instead , silencing of *resulted* in a reduction of overall [cyclin D1] expression , a reduction of EGF induced increase in cyclin D1 expression and an increase in apoptotic cell population compared with control cells . Positive_regulation CCND1 NTF3 17404514 1735991 CNP inhibits *induced* [cyclin D1] expression , and induces the expression of different profiles of inhibitory cell cycle proteins , which are neurotrophin-specific and correlate with the attainment of different maturational cell fates . Positive_regulation CCND1 NTF4 17404514 1735992 CNP inhibits *induced* [cyclin D1] expression , and induces the expression of different profiles of inhibitory cell cycle proteins , which are neurotrophin-specific and correlate with the attainment of different maturational cell fates . Positive_regulation CCND1 NUP43 8702807 376057 [Cyclin D1] expression is *regulated* positively by the and negatively by the p38/HOGMAPK pathway . Positive_regulation CCND1 NUP43 8702807 376062 We found that inhibition of the ( MAPK ) signaling by expression of dominant negative forms of either mitogen activated protein kinase kinase 1 ( MKK1 ) or p44 ( MAPK ) , or by expression of the MAP kinase phosphatase , MKP-1 , strongly *inhibited* expression of a reporter gene driven by the human cyclin D1 promoter as well as the endogenous [cyclin D1] protein . Positive_regulation CCND1 OPA1 21928377 2539199 meanwhile , the expressions of FLT3 , p65 , [cyclin D1] , and Bc1-2 decreased significantly , and the expression of nuclear Silencing for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation CCND1 OPN1SW 16352701 1533240 Blockade of the beta-catenin expression by small interfering RNA approach attenuated *induced* expression of [cyclin D1] , indicating that the induction was mediated by beta-catenin/Tcf/Lef pathway . Positive_regulation CCND1 OPN1SW 19570744 2129060 Further studies have revealed that Nurr1 may mediate cyclin D1 expression and I-BOP induced cell proliferation in H157 cells since small interfering RNA of Nurr1 blocked *induced* [cyclin D1] expression and cell proliferation and also decreased cell growth rate . Positive_regulation CCND1 PAK1 14530270 1185881 signaling *mediates* [cyclin D1] expression in mammary epithelial and cancer cells . Positive_regulation CCND1 PAK1 14657670 1188537 is *essential* for RAS induced upregulation of [cyclin D1] during the G1 to S transition . Positive_regulation CCND1 PAK1 15743831 1379117 Furthermore , *stimulated* [cyclin D1] promoter activity was repressed by cotransfection of NF2 , and PAK activity was inhibited by expression of merlin . Positive_regulation CCND1 PAK1 15743831 1379121 Collectively , our data indicate that merlin exerts its antiproliferative effect , at least in part , via repression of *induced* [cyclin D1] expression , suggesting a unifying mechanism by which merlin inactivation might contribute to the overgrowth seen in both noninvasive and malignant tumors . Positive_regulation CCND1 PAK1 21719533 2471261 *regulates* [cyclin D1] promoter activity in response to prolactin . Positive_regulation CCND1 PAK2 14657670 1188538 is *essential* for RAS induced upregulation of [cyclin D1] during the G1 to S transition . Positive_regulation CCND1 PAK2 15743831 1379122 Collectively , our data indicate that merlin exerts its antiproliferative effect , at least in part , via repression of *induced* [cyclin D1] expression , suggesting a unifying mechanism by which merlin inactivation might contribute to the overgrowth seen in both noninvasive and malignant tumors . Positive_regulation CCND1 PAK3 14657670 1188539 is *essential* for RAS induced upregulation of [cyclin D1] during the G1 to S transition . Positive_regulation CCND1 PAK3 15743831 1379123 Collectively , our data indicate that merlin exerts its antiproliferative effect , at least in part , via repression of *induced* [cyclin D1] expression , suggesting a unifying mechanism by which merlin inactivation might contribute to the overgrowth seen in both noninvasive and malignant tumors . Positive_regulation CCND1 PAK4 14657670 1188532 is *essential* for RAS induced upregulation of [cyclin D1] during the G1 to S transition . Positive_regulation CCND1 PAK4 15743831 1379119 Collectively , our data indicate that merlin exerts its antiproliferative effect , at least in part , via repression of *induced* [cyclin D1] expression , suggesting a unifying mechanism by which merlin inactivation might contribute to the overgrowth seen in both noninvasive and malignant tumors . Positive_regulation CCND1 PAK6 14657670 1188533 is *essential* for RAS induced upregulation of [cyclin D1] during the G1 to S transition . Positive_regulation CCND1 PAK6 15743831 1379120 Collectively , our data indicate that merlin exerts its antiproliferative effect , at least in part , via repression of *induced* [cyclin D1] expression , suggesting a unifying mechanism by which merlin inactivation might contribute to the overgrowth seen in both noninvasive and malignant tumors . Positive_regulation CCND1 PAK7 14657670 1188531 is *essential* for RAS induced upregulation of [cyclin D1] during the G1 to S transition . Positive_regulation CCND1 PAK7 15743831 1379118 Collectively , our data indicate that merlin exerts its antiproliferative effect , at least in part , via repression of *induced* [cyclin D1] expression , suggesting a unifying mechanism by which merlin inactivation might contribute to the overgrowth seen in both noninvasive and malignant tumors . Positive_regulation CCND1 PAX2 23135283 2707304 Inhibition of *results* in a decreased expression of [cyclin D1] . Positive_regulation CCND1 PAX2 23135283 2707313 We find that knockdown of PAX2 inhibits the activity of AP-1 , a transcription factor that induces cyclin D1 expression , implying that *induces* [cyclin D1] through AP-1 . Positive_regulation CCND1 PAX6 24454925 2907447 The [cyclin D1] protein level , as well as the pRB phosphorylation level , decreased as a *result* of down-regulation . Positive_regulation CCND1 PC 20394812 2262239 Fibroblasts carrying a mutant form of cyclin D1 ( T286A ) were resistant to *induced* degradation of [cyclin D1] . Positive_regulation CCND1 PCNA 11154267 770706 Estrogens induce proliferation of estrogen receptor (ER) positive MCF-7 breast cancer cells by stimulating G ( 1 ) /S transition associated with increased [cyclin D1] expression , *activation* of , and phosphorylation of the retinoblastoma protein ( pRb ) . Positive_regulation CCND1 PCNA 11497245 846502 Treatment of MCF-7 cells with PM-3 arrested cells in the G1 phase and resulted in a decrease in the protein levels of cyclin D1 and E. PM-3 also *inhibited* the expression of [cyclin D1] at the transcriptional level when examined in cyclin D1 promoter luciferase assays . Positive_regulation CCND1 PCNA 14614307 779928 [Cyclin D1] expression was *detected* in 56.3 % of the adenomas and in 61.5 % of the adenocarcinomas examined , whereas E expression was detected in 87.5 % of the adenomas and in 92.3 % of the adenocarcinomas . Positive_regulation CCND1 PCNA 15033176 1223351 IGF-I enhanced FGF-2 induction of [cyclin D1] , *activation* of G ( 1 ) dependent kinase (cdk) complexes , and hyperphosphorylation of retinoblastoma protein ( pRb ) . Positive_regulation CCND1 PCNA 16023250 1441604 Exposure to RS is able to block cell cycle progression after [cyclin D1] and *induction* , but prior to S phase . Positive_regulation CCND1 PCNA 16551874 1537944 Ritonavir causes G1 arrest , depletes *dependent* kinases 2 , 4 , and 6 and [cyclin D1] but not cyclin E , and depletes phosphorylated Rb and Ser473 Akt . Positive_regulation CCND1 PCNA 18023328 1866882 4 and 6 are cyclin D1 binding partners , and *activated* [cyclin D1/CDK4] and cyclin D1/CDK6 complex phosphorylate the retinoblastoma protein to induce the expression of target genes essential for S phase entry , resulting in facilitation of the progression from G1 to S phase . Positive_regulation CCND1 PCNA 21270666 2431165 Associated with G0/G1 arrest , ritonavir down-regulates *dependent* kinases , [cyclin D1] , and retinoblastoma protein phosphorylation . Positive_regulation CCND1 PCNA 23390492 2739702 Accumulation or over-expression of occurs in a majority of breast cancers and over-expression of CCND1 *leads* to accumulation of activated [CCND1/CDK2] complexes in breast cancer cells . Positive_regulation CCND1 PCNA 9244353 446259 We demonstrate that both [cyclin D1] and CDK4 functionally depend on active Myc to exert their potential as oncogenes and vice versa that the transforming ability of Myc *requires* functional D/CDK complexes . Positive_regulation CCND1 PDGFB 15094364 1238300 STI571 abrogates *dependent* [cyclin D1] and cyclin A protein expression and inhibits transcriptional activation of reporter genes driven by the human cyclin A gene promoter . Positive_regulation CCND1 PDGFB 16294327 1532381 Curcumin inhibited *induced* [cyclin D1] expression and activation of extracellular signal regulated kinase ( ERK ) . Positive_regulation CCND1 PDGFB 17823285 1801960 *induced* [cyclin D1] expression , CDK4 activity , and Rb protein phosphorylation , leading to VSMC growth and motility , and these responses were suppressed by the blockade of STAT-5B . Positive_regulation CCND1 PDGFB 21348889 2420582 In addition , TSG significantly inhibited *induced* phosphorylation of Rb and the expression of [cyclin D1] , CDK4 , cyclin E , CDK2 and PCNA . Positive_regulation CCND1 PDGFB 21533767 2458575 Berberine and DHEAS decreased the expression of CDK2 , CDK4 , PCNA , [cyclin D1] , and cyclin E , which was *induced* by . Positive_regulation CCND1 PDGFB 23866995 2854416 It also blocked *induced* expression of [cyclin D1] . Positive_regulation CCND1 PDGFB 24106713 2852545 Western blot analysis showed that *induced* activation of [cyclin D1] was inhibited by CC10 . Positive_regulation CCND1 PDGFB 8831499 385734 induced an *increase* in mRNA levels of [cyclin D1] , cyclin dependent kinase (cdk) 4 , and cdk2 , as well as the activity of cdk2 , which preceded the G1/S boundary , as estimated by the kinetics of DNA synthesis . Positive_regulation CCND1 PDGFB 8831499 385738 In contrast , TNP-470 had no or less marked effect on [cyclin D1] and cdk4 mRNA levels *induced* by . Positive_regulation CCND1 PDGFRB 10688905 670288 Moreover , by using the specific platelet derived growth factor receptor ( PDGFR ) inhibitor AG 1296 or by overexpressing a kinase-mutant PDGFR , we show that kinase activity is *essential* for 5-HT2B triggered [MAPK/cyclin D1] , but not cyclin E , signaling pathways . Positive_regulation CCND1 PDGFRB 17545544 1751966 Sorafenib blocked receptor autophosphorylation and signaling of KIT and gatekeeper mutants in intact cells as well as *activation* of AP1-responsive and [cyclin D1] gene promoters , respectively . Positive_regulation CCND1 PDLIM7 24499623 2884886 Our previous study demonstrated that the nuclear EGFR could bind to the [cyclin D1] promoter directly in the *presence* of , and the correlation between EGFR and STAT3 in NPC remains to be further explored . Positive_regulation CCND1 PDLIM7 24499623 2884899 These findings may provide a novel linkage between the EGFR and STAT3 signaling pathways and the *activation* of [cyclin D1] by in the carcinogenesis of NPC . Positive_regulation CCND1 PGF 10733897 678568 In contrast , in PKC depleted or -inhibited cells , ( 2alpha ) , but not OAG , *increases* [cyclin D1] expression with no mitogenic response . Positive_regulation CCND1 PGF 10733897 678569 Thus , it appears that ( 2alpha ) *triggers* [cyclin D1] expression via two independent signaling events that complement with TGF(beta1) triggered events to induce DNA synthesis . Positive_regulation CCND1 PHF15 19430401 2077849 Overexpression of could induce growth suppression and apoptosis enhancement in M14 cells , and also *induce* the upregulation of p27 , Bax and Cyt-c , and the downregulation of [cyclinD1] , SKP2 , Bcl-2 , and caspase-3 . Positive_regulation CCND1 PHF17 18399550 1893741 Overexpression of can induce growth inhibition in A549 cells both in vitro and in vivo , and also *induce* up-regulation of p27 , down-regulation of [cyclinD1] , SKP2 , and Cox2 , and inactivation of the Wnt-1/beta-catenin pathway . Positive_regulation CCND1 PHIP 23118901 2696022 GLT treatment also significantly down-regulated *dependent* expression of [cyclin D1] , COX-2 , CYP1A2 and CYP3A4 in colon tissue . Positive_regulation CCND1 PI3 10419529 631926 activity is *required* for the expression of endogenous [cyclin D(1)] and for S phase entry following serum stimulation of quiescent NIH 3T3 fibroblasts . Positive_regulation CCND1 PI3 10419529 631938 Activated *induces* [cyclin D(1)] transcription and E2F activity , at least in part mediated by the serine/threonine kinase Akt/PKB , and to a lesser extent the Rho family GTPase Rac . Positive_regulation CCND1 PI3 11017907 737629 Further , PDGF , , and Rac1 each *activated* the [cyclin D(1)] promoter at the cyclic adenosine monophosphate response element binding protein ( CREB ) /activating transcription factor (ATF)-2 binding site , as evidenced by expression of a CREB/ATF-2 reporter plasmid . Positive_regulation CCND1 PI3 11017907 737639 Together , these data suggest that in airway smooth muscle ( ASM ) cells , *regulates* transcription from the [cyclin D(1)] promoter and DNA synthesis in an ERK independent manner . Positive_regulation CCND1 PI3 14592948 1200014 IGF-I elicited a time dependent increase in [cyclin D1] protein levels *mediated* jointly by ERK1/2 dependent and dependent mechanisms . Positive_regulation CCND1 PI3 16387740 1533424 Furthermore , inhibition of by overexpression of Deltap85 or DN-Akt *blocked* arsenite induced IKK phosphorylation , IkappaBalpha degradation and [cyclin D1] expression , indicating that IKK/NFkappaB is the downstream transducer of arsenite triggered PI-3K/Akt cascade . Positive_regulation CCND1 PI3 17700539 1848732 Transcriptional activation of c-myc and [cyclin D1] promoters by nuclear IRS-1 does not occur with a mutant , inactive IRS-1 protein ( deletion of the phosphotyrosine binding domain , PTB ) and does not *require* activity . Positive_regulation CCND1 PI3 18197291 1857171 Our results demonstrate that *mediated* [cyclin D1] expression is at least one key event implicated in the arsenite human skin carcinogenic effect . Positive_regulation CCND1 PI3 18403485 1925962 In contrast , IGF-I dependent activation was *required* for the increase in [cyclin D1] mRNA levels and degradation of p27 ( Kip1 ) . Positive_regulation CCND1 PI3 20930115 2381813 Increases in [cyclin D1] protein induced by FCS or LXA ( 4 ) were *blocked* by the kinase inhibitor , LY294002 , and attenuated by FPR2 antagonism using Boc2 . Positive_regulation CCND1 PI3 9858556 582056 Activation of is indirect , perhaps through autocrine growth factors , and is *required* for the induction of [cyclin D1] . Positive_regulation CCND1 PI3 9891068 586312 These results indicate that the catalytic activity of is necessary , and could also be *sufficient* , for upregulation of [cyclin D1] , with mTOR signaling being differentially required depending upon cellular conditions . Positive_regulation CCND1 PIK3CA 10611246 656160 Induction of [cyclin D1] by NeuT *involved* Ras , Rac , Rho , extracellular signal regulated kinase , c-Jun N-terminal kinase , and p38 , but not . Positive_regulation CCND1 PIK3CA 10843991 721997 Using a pharmacological and a co-transfection approach , we found that p21(ras) , Raf-1 , and also the catalytic activity of SHP-2 and its Src homology 2 domains are *required* for [cyclin D1] promoter/reporter gene activation by Ang II through the regulation of MAPK/ERK activity . Positive_regulation CCND1 PIK3CA 12242655 990019 PI3K signalling also participated in cell cycle progression , since and MAPK coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Positive_regulation CCND1 PIK3CA 12589056 1059885 PI3K dependent induction of [cyclin D1] was *blocked* by inhibitors of or beta-catenin signaling . Positive_regulation CCND1 PIK3CA 12907754 1157468 Moreover , we show that both and c-Src/Fak/Erk1/2 pathways are *involved* in the up-regulation of c-myc and [cyclin d1] expression mediated by PRL . Positive_regulation CCND1 PIK3CA 15342383 1291918 Inhibition of either pathway reduced expression of cyclins D1 , D2 , and D3 in RMS lines , whereas only inhibitors *blocked* [cyclin D1] , D2 , and D3 expression in ET lines . Positive_regulation CCND1 PIK3CA 16405968 1513281 The Reg/ATF-2 induced [cyclin D1] promoter activation was *attenuated* by inhibitors such as LY294002 and wortmannin . Positive_regulation CCND1 PIK3CA 17508424 1761888 Moreover , the presence of IGF-I significantly enhances nuclear localization of [cyclin D1] , which also *requires* signaling . Positive_regulation CCND1 PIK3CA 17941827 1849436 Inhibition of EGFR , ( phosphoinositide 3-kinase ; kinases required for Rac activation by HRG ) or MEK [ MAPK ( mitogen activated protein kinase ) /ERK ( extracellular-signal regulated kinase ) kinase ] also *blocked* the up-regulation of [cyclin D1 and p21(Cip1)] by HRG . Positive_regulation CCND1 PIK3CA 18434386 1932574 These data reveal that Src is a crucial mediator of RPTC proliferation and Src mediated proliferation is associated with *dependent* upregulation of [cyclin D1] and PI3K independent downregulation of p27 and p57 . Positive_regulation CCND1 PIK3CA 20724534 2306865 These findings demonstrate for the first time that dependent [cyclin D1] *activation* plays an essential role in HDL induced EPC proliferation , migration and angiogenesis . Positive_regulation CCND1 PIK3CA 22579115 2609547 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated [Cyclin D1] and Cyclin B1 proteins as well as *activation* of and Raf/MEK/ERK , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation CCND1 PIK3CA 23300886 2712472 Pharmacological inhibition of JAK/STAT3 , or MEK/ERK signaling by AG490 , Wortmannin or U0126 , respectively , *reduced* leptin induced [cyclin D1] expression and NP cell proliferation . Positive_regulation CCND1 PIK3CA 24008581 2845919 Inhibitors of or Erk1/2 *inhibited* [cyclin D1] expression and G1 progression when added 12 hours after EGF stimulation , whereas depletion of EGF from the medium at this time point did not . Positive_regulation CCND1 PIK3CA 9891068 586310 [Cyclin D1] expression *mediated* by through mTOR-p70 ( S6K ) -independent signaling in growth factor stimulated NIH 3T3 fibroblasts . Positive_regulation CCND1 PIK3R1 10611246 656161 Induction of [cyclin D1] by NeuT *involved* Ras , Rac , Rho , extracellular signal regulated kinase , c-Jun N-terminal kinase , and p38 , but not . Positive_regulation CCND1 PIK3R1 10843991 721998 Using a pharmacological and a co-transfection approach , we found that p21(ras) , Raf-1 , and also the catalytic activity of SHP-2 and its Src homology 2 domains are *required* for [cyclin D1] promoter/reporter gene activation by Ang II through the regulation of MAPK/ERK activity . Positive_regulation CCND1 PIK3R1 12242655 990020 PI3K signalling also participated in cell cycle progression , since and MAPK coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Positive_regulation CCND1 PIK3R1 12589056 1059886 *dependent* induction of [cyclin D1] was blocked by inhibitors of PI3K/Akt/IkappaB/IKKalpha or beta-catenin signaling . Positive_regulation CCND1 PIK3R1 12907754 1157469 Moreover , we show that both and c-Src/Fak/Erk1/2 pathways are *involved* in the up-regulation of c-myc and [cyclin d1] expression mediated by PRL . Positive_regulation CCND1 PIK3R1 15342383 1291919 Inhibition of either pathway reduced expression of cyclins D1 , D2 , and D3 in RMS lines , whereas only inhibitors *blocked* [cyclin D1] , D2 , and D3 expression in ET lines . Positive_regulation CCND1 PIK3R1 16405968 1513282 The Reg/ATF-2 induced [cyclin D1] promoter activation was *attenuated* by inhibitors such as LY294002 and wortmannin . Positive_regulation CCND1 PIK3R1 17508424 1761889 Moreover , the presence of IGF-I significantly enhances nuclear localization of [cyclin D1] , which also *requires* signaling . Positive_regulation CCND1 PIK3R1 17941827 1849437 Inhibition of EGFR , ( phosphoinositide 3-kinase ; kinases required for Rac activation by HRG ) or MEK [ MAPK ( mitogen activated protein kinase ) /ERK ( extracellular-signal regulated kinase ) kinase ] also *blocked* the up-regulation of [cyclin D1 and p21(Cip1)] by HRG . Positive_regulation CCND1 PIK3R1 18434386 1932575 These data reveal that Src is a crucial mediator of RPTC proliferation and Src mediated proliferation is associated with *dependent* upregulation of [cyclin D1] and PI3K independent downregulation of p27 and p57 . Positive_regulation CCND1 PIK3R1 20724534 2306866 These findings demonstrate for the first time that dependent [cyclin D1] *activation* plays an essential role in HDL induced EPC proliferation , migration and angiogenesis . Positive_regulation CCND1 PIK3R1 22579115 2609548 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated [Cyclin D1] and Cyclin B1 proteins as well as *activation* of and Raf/MEK/ERK , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation CCND1 PIK3R1 23300886 2712473 Pharmacological inhibition of JAK/STAT3 , or MEK/ERK signaling by AG490 , Wortmannin or U0126 , respectively , *reduced* leptin induced [cyclin D1] expression and NP cell proliferation . Positive_regulation CCND1 PIK3R1 24008581 2845920 Inhibitors of or Erk1/2 *inhibited* [cyclin D1] expression and G1 progression when added 12 hours after EGF stimulation , whereas depletion of EGF from the medium at this time point did not . Positive_regulation CCND1 PIK3R1 9891068 586311 [Cyclin D1] expression *mediated* by through mTOR-p70 ( S6K ) -independent signaling in growth factor stimulated NIH 3T3 fibroblasts . Positive_regulation CCND1 PIN1 12540053 1028573 We also showed that in neuronal cells , *upregulates* the expression of [cyclin D1] . Positive_regulation CCND1 PIN1 15095272 1238367 Cyclin D1 is a target molecule transcriptionally activated by aberrant beta-catenin in Wnt signalling , while prolyl isomerase *promotes* [cyclin D1] overexpression directly or through accumulation of beta-catenin in cancer cells . Positive_regulation CCND1 PIN1 15095272 1238368 This study aimed to elucidate whether was *involved* in [cyclin D1] overexpression and aberrant beta-catenin in thyroid tumourigenesis by examining 14 follicular adenomas (FAa) and 14 papillary thyroid carcinomas ( PTCs ) . Positive_regulation CCND1 PIN1 16820873 1581575 Here , we investigated the *role* of in association with [cyclinD1] in esophageal SCC progression and its clinicopathological significance . Positive_regulation CCND1 PIN1 16865248 1592732 In this study , whether is *involved* in cervical oncogenesis by regulating [cyclin D1] was explored and the potential of Pin1 targeted gene silencing in inhibiting cellular growth and tumorigenicity in cervical cancer was investigated . Positive_regulation CCND1 PIN1 16865248 1592734 The results showed that directly *regulated* [cyclin D1] levels . Positive_regulation CCND1 PIN1 16865250 1592736 The aims of this study were to investigate the expression levels of beta-catenin , Pin1 and cyclin D1 in salivary adenoid cystic carcinomas ( SACC ) and to evaluate its clinical importance , furthermore , to elucidate whether beta-catenin expression was aberrant in SACC and whether was *involved* in aberrant beta-catenin and [cyclin D1] expression . Positive_regulation CCND1 PIN1 21640077 2446156 Exposure of epidermal cells to UVA radiation increased cell proliferation and [cyclin D1] expression , and these changes were *blocked* by inhibition . Positive_regulation CCND1 PITX2 12629224 1067346 Here , we report that , in response to the Wntbeta-catenin pathway and growth signals , also can *regulate* c-Myc and [cyclin D1] . Positive_regulation CCND1 PITX2 20019746 2247987 associates with a ribonucleoprotein complex that includes the mRNA *stabilizing* factor HuR and sustains [Ccnd1] ( also known as Cyclin D1 ) expression , thereby prolonging its mRNA half-life . Positive_regulation CCND1 PKN1 14530270 1185882 Increased expression of in breast cancer cells *stimulated* [cyclin D1] promoter activity , elevated levels of cyclin D1 mRNA , protein , and nuclear accumulation of cyclin D1 . Positive_regulation CCND1 PKN1 14530270 1185883 Conversely , inhibition by an auto-inhibitory peptide ( amino acids 83-149 ) or Pak1 knockdown by short interference RNA markedly *reduced* the expression of [cyclin D1] , suggesting a requirement of a functional Pak1 pathway for optimal expression of cyclin D1 . Positive_regulation CCND1 PKN1 14530270 1185884 Results from deletion and mutant analysis indicate that *regulates* [cyclin D1] transcription by means of an NF-kappaB dependent pathway . Positive_regulation CCND1 PKN1 14583477 1158991 Overexpression of the PAK1 autoinhibitory domain ( residues 83-149 ) but not an inactive autoinhibitory domain point mutant ( L107F ) also *blocked* BCAR3 mediated [cyclin D1] activation . Positive_regulation CCND1 PKN1 14657670 1188547 In this report , using two distinct inhibitors specific for PAK1-3 ( CEP-1347 and WR-PAK18 ) , we present the first evidence indicating that the PIX/Rac/CDC42 dependent Ser/Thr kinases , acting downstream of PI-3 kinase and upstream of the Raf/MEK/ERKs kinase cascade , is *essential* for RAS induced upregulation of [cyclin D1] , but not downregulation of p27 . Positive_regulation CCND1 PLA2G4A 23500889 2776944 Doxycycline ( Dox ) -induced expression of *led* to an increase in pAKT , pGSK3ß and [cyclin D1] levels in LNCaP cells that possess a PTEN frame-shift mutation . Positive_regulation CCND1 PLAT 15695395 1371847 beta-Catenin silencing through small interfering RNA and antisense oligonucleotides inhibited both the *mediated* [cyclin D1] expression and cell proliferation . Positive_regulation CCND1 PLAT 20724593 2323795 Blockade of Erk1/2 activation or knockdown of p90RSK suppressed *induced* GSK3ß phosphorylation , [cyclin D1] expression , and fibroblast proliferation . Positive_regulation CCND1 PLAT 20724593 2323796 Ectopic overexpression of an uninhibitable GSK3ß mutant eliminated *induced* [cyclin D1] expression . Positive_regulation CCND1 PLAT 23632004 2838297 In primary culture VSMCs , sustained stimulation with induced collagen type I upregulation and *triggered* sequential signaling events involving Akt , extracellular signal regulated kinases 1/2 ( ERK1/2 ) , glycogen synthase kinase-3 (GSK3)-ß phosphorylation , and [cyclin D1] induction . Positive_regulation CCND1 PLAT 23632004 2838302 Blockade of phosphatidylinositol 3-kinase-Akt and ERK1/2 activation suppressed *induced* GSK3ß phosphorylation , [cyclin D1] expression , and the deposition of collagen type I . Positive_regulation CCND1 PLEKHO1 24114209 2852674 In summary , plays a protective role on radiation induced bone marrow through the activation of the Wnt3a signaling pathway , and *promotes* the transcription and expression of [Cyclin D1] . Positive_regulation CCND1 PML 10763819 683924 Neither nor eIF-4E *cause* significant changes in [cyclin D1] mRNA levels . Positive_regulation CCND1 PMPCB 16260626 1478090 complexes *induced* [cyclin D1] and c-myc promoter activities and failed in electrophoretic mobility shift assay to interact with IkappaB-alpha-glutathione S-transferase , indicating that their weak interaction with IkappaB-alpha can account for the observed recovery of mammary gland development . Positive_regulation CCND1 PMPCB 20420878 2267946 Moreover , we further demonstrated that complex formation *enhanced* [cyclin D1] expression through the cyclin D1 gene promoter via its kappaB site . Positive_regulation CCND1 PMPCB 20420878 2267948 The up-regulation of [cyclin D1] *mediated* by the complex in response to low concentration arsenite might be important in assessing the health risk of low concentration arsenite and understanding the mechanisms of the harmful effects of arsenite . Positive_regulation CCND1 POLDIP2 10611246 656156 Induction of [cyclin D1] by NeuT *involved* Ras , Rac , Rho , extracellular signal regulated kinase , c-Jun N-terminal kinase , and , but not phosphatidylinositol 3-kinase . Positive_regulation CCND1 POLDIP2 12771941 1094836 Finally , both [cyclin D1] induction and HBX mitotic activity are *dependent* on and c-Jun N-terminal kinase , but not on MEK-1 kinase activity . Positive_regulation CCND1 POLDIP2 18692155 2020165 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to *dependent* activation of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Positive_regulation CCND1 POLR2A 15226187 1301802 Our results suggest a model where bound at IgH regulatory sequences can *activate* the [cyclin D1] promoter by either long-range polymerase transfer or tracking . Positive_regulation CCND1 POLR2B 15226187 1301803 Our results suggest a model where bound at IgH regulatory sequences can *activate* the [cyclin D1] promoter by either long-range polymerase transfer or tracking . Positive_regulation CCND1 POLR2C 15226187 1301804 Our results suggest a model where bound at IgH regulatory sequences can *activate* the [cyclin D1] promoter by either long-range polymerase transfer or tracking . Positive_regulation CCND1 POLR2D 15226187 1301805 Our results suggest a model where bound at IgH regulatory sequences can *activate* the [cyclin D1] promoter by either long-range polymerase transfer or tracking . Positive_regulation CCND1 POLR2E 15226187 1301806 Our results suggest a model where bound at IgH regulatory sequences can *activate* the [cyclin D1] promoter by either long-range polymerase transfer or tracking . Positive_regulation CCND1 POLR2F 15226187 1301807 Our results suggest a model where bound at IgH regulatory sequences can *activate* the [cyclin D1] promoter by either long-range polymerase transfer or tracking . Positive_regulation CCND1 POLR2G 15226187 1301808 Our results suggest a model where bound at IgH regulatory sequences can *activate* the [cyclin D1] promoter by either long-range polymerase transfer or tracking . Positive_regulation CCND1 POLR2H 15226187 1301809 Our results suggest a model where bound at IgH regulatory sequences can *activate* the [cyclin D1] promoter by either long-range polymerase transfer or tracking . Positive_regulation CCND1 POLR2I 15226187 1301810 Our results suggest a model where bound at IgH regulatory sequences can *activate* the [cyclin D1] promoter by either long-range polymerase transfer or tracking . Positive_regulation CCND1 POLR2J 15226187 1301811 Our results suggest a model where bound at IgH regulatory sequences can *activate* the [cyclin D1] promoter by either long-range polymerase transfer or tracking . Positive_regulation CCND1 POLR2K 15226187 1301812 Our results suggest a model where bound at IgH regulatory sequences can *activate* the [cyclin D1] promoter by either long-range polymerase transfer or tracking . Positive_regulation CCND1 POLR2L 15226187 1301813 Our results suggest a model where bound at IgH regulatory sequences can *activate* the [cyclin D1] promoter by either long-range polymerase transfer or tracking . Positive_regulation CCND1 POU2F1 24121026 2889187 T3 enhances thyroid cancer cell proliferation through *mediated* [cyclin D1] activation . Positive_regulation CCND1 POU5F1 25128069 2957237 In this study , the wild-type and the octamer motif mutanted CCND1 promoters were cloned , and their corresponding luciferase reporter vectors were then constructed to study the molecular mechanism by which *regulates* the expression of [CCND1] and influences the biological behaviors of esophageal cancer cells . Positive_regulation CCND1 POU5F1 25128069 2957239 Suppression of expression significantly decreased the wild-type CCND1 promoter activity and *down-regulated* the expression of [CCND1] , but did not affect the activity of the mutant promoter . Positive_regulation CCND1 PPARG 14764597 1235121 Our aim was to elucidate the pathway of activation *mediated* modulation of [cyclin D1] transcription in mouse hepatocytes . Positive_regulation CCND1 PPP3CA 16408277 1540198 Pharmacological inhibition of by cyclosporin A *blocks* IGF-1 induced [cyclin D1] and p21Cip1expression significantly ( P < 0.05 ) . Positive_regulation CCND1 PPP3CB 16408277 1540199 Pharmacological inhibition of by cyclosporin A *blocks* IGF-1 induced [cyclin D1] and p21Cip1expression significantly ( P < 0.05 ) . Positive_regulation CCND1 PPP3CC 16408277 1540200 Pharmacological inhibition of by cyclosporin A *blocks* IGF-1 induced [cyclin D1] and p21Cip1expression significantly ( P < 0.05 ) . Positive_regulation CCND1 PPP5C 22219213 2579913 E2- or , through activation of epidermal growth factor receptor (EGFR)/mitogen activated protein kinase 3/1 ( MAPK3/1 ) and PIK3 pathways , *induces* upregulation of [CCND1] . Positive_regulation CCND1 PRDX2 15585645 1345662 In the ERalpha positive MCF-7 cell line , repressed ERalpha and cyclin D1 transcription and *induced* ubiquitin dependent proteasomal degradation of [cyclin D1] , leading primarily to G ( 1 ) -S-phase cell cycle arrest . Positive_regulation CCND1 PRDX2 16503970 1529136 We have demonstrated previously , that *induces* the ubiquitin dependent degradation of [cyclin D1] in MCF-7 breast cancer cells . Positive_regulation CCND1 PRDX2 16504004 1535433 We have previously shown that the histone deacetylase inhibitor *induces* the rapid ubiquitin dependent degradation of [cyclin D1] in MCF-7 breast cancer cells prior to repression of cyclin D1 gene (CCND1) transcription . Positive_regulation CCND1 PRDX2 16504004 1535434 Here we provide further evidence for *induced* ubiquitin dependent degradation of [cyclin D1] and demonstrate that GSK3beta mediated nuclear export facilitates this activity . Positive_regulation CCND1 PRDX2 16504004 1535435 We have demonstrated that rapid *induced* [cyclin D1] degradation in MCF-7 cells requires GSK3beta mediated Thr-286 phosphorylation and the ubiquitin dependent 26S proteasome pathway . Positive_regulation CCND1 PRDX2 23013422 2734982 We observed that *increased* the expression of proliferating cell nuclear antigen and [cyclin D1] in hDPSCs at a certain concentration and the activation of JNK/c-Jun pathway was essential for TSA dependent hDPSC proliferation . Positive_regulation CCND1 PRDX2 24280698 2714876 Disparity in butyrate- and *induced* [cyclin D1] may influence transcriptional regulation of genes that are associated with changes in cellular morphology/cellular effects that these HDACi confer on VSMC , as a transcriptional modulator . Positive_regulation CCND1 PRH2 10523665 653570 Finally , we have observed that Dbl and *regulated* transcription from the [cyclin D1] promoter in a NF-kappaB dependent manner . Positive_regulation CCND1 PRKAA1 24236567 2903143 We suggest that these tumours may arise through a mechanism involving ATP depletion , *activation* of , and induction of [cyclin D1] , and that this may be a unique pathway of tumour development that has the potential for therapeutic intervention in these rare tumours . Positive_regulation CCND1 PRKAA2 24236567 2903144 We suggest that these tumours may arise through a mechanism involving ATP depletion , *activation* of , and induction of [cyclin D1] , and that this may be a unique pathway of tumour development that has the potential for therapeutic intervention in these rare tumours . Positive_regulation CCND1 PRKAB1 24236567 2903145 We suggest that these tumours may arise through a mechanism involving ATP depletion , *activation* of , and induction of [cyclin D1] , and that this may be a unique pathway of tumour development that has the potential for therapeutic intervention in these rare tumours . Positive_regulation CCND1 PRKAB2 24236567 2903146 We suggest that these tumours may arise through a mechanism involving ATP depletion , *activation* of , and induction of [cyclin D1] , and that this may be a unique pathway of tumour development that has the potential for therapeutic intervention in these rare tumours . Positive_regulation CCND1 PRKACB 18353896 1906259 Using the PKA inhibitor PKI or dominant negative TCF-4 mutant , we show that ATP induced [cyclin D1] promoter activation , cyclin D1 protein expression , and proliferation of VSMC are all *dependent* on and TCF activities . Positive_regulation CCND1 PRKACB 23571712 2838029 Finally , inhibition *attenuated* the effect of GLP-1 ( 28-36 ) amide on ß-cat Ser ( 675 ) phosphorylation and [cyclin D1] expression in the INS-1 cell line . Positive_regulation CCND1 PRKACG 18353896 1906260 Using the PKA inhibitor PKI or dominant negative TCF-4 mutant , we show that ATP induced [cyclin D1] promoter activation , cyclin D1 protein expression , and proliferation of VSMC are all *dependent* on and TCF activities . Positive_regulation CCND1 PRKACG 23571712 2838030 Finally , inhibition *attenuated* the effect of GLP-1 ( 28-36 ) amide on ß-cat Ser ( 675 ) phosphorylation and [cyclin D1] expression in the INS-1 cell line . Positive_regulation CCND1 PRKAG1 24236567 2903147 We suggest that these tumours may arise through a mechanism involving ATP depletion , *activation* of , and induction of [cyclin D1] , and that this may be a unique pathway of tumour development that has the potential for therapeutic intervention in these rare tumours . Positive_regulation CCND1 PRKAG2 24236567 2903148 We suggest that these tumours may arise through a mechanism involving ATP depletion , *activation* of , and induction of [cyclin D1] , and that this may be a unique pathway of tumour development that has the potential for therapeutic intervention in these rare tumours . Positive_regulation CCND1 PRKAR1A 18353896 1906261 Using the PKA inhibitor PKI or dominant negative TCF-4 mutant , we show that ATP induced [cyclin D1] promoter activation , cyclin D1 protein expression , and proliferation of VSMC are all *dependent* on and TCF activities . Positive_regulation CCND1 PRKAR1A 23571712 2838031 Finally , inhibition *attenuated* the effect of GLP-1 ( 28-36 ) amide on ß-cat Ser ( 675 ) phosphorylation and [cyclin D1] expression in the INS-1 cell line . Positive_regulation CCND1 PRKAR1B 18353896 1906262 Using the PKA inhibitor PKI or dominant negative TCF-4 mutant , we show that ATP induced [cyclin D1] promoter activation , cyclin D1 protein expression , and proliferation of VSMC are all *dependent* on and TCF activities . Positive_regulation CCND1 PRKAR1B 23571712 2838032 Finally , inhibition *attenuated* the effect of GLP-1 ( 28-36 ) amide on ß-cat Ser ( 675 ) phosphorylation and [cyclin D1] expression in the INS-1 cell line . Positive_regulation CCND1 PRKAR2A 18353896 1906263 Using the PKA inhibitor PKI or dominant negative TCF-4 mutant , we show that ATP induced [cyclin D1] promoter activation , cyclin D1 protein expression , and proliferation of VSMC are all *dependent* on and TCF activities . Positive_regulation CCND1 PRKAR2A 23571712 2838033 Finally , inhibition *attenuated* the effect of GLP-1 ( 28-36 ) amide on ß-cat Ser ( 675 ) phosphorylation and [cyclin D1] expression in the INS-1 cell line . Positive_regulation CCND1 PRKAR2B 18353896 1906264 Using the PKA inhibitor PKI or dominant negative TCF-4 mutant , we show that ATP induced [cyclin D1] promoter activation , cyclin D1 protein expression , and proliferation of VSMC are all *dependent* on and TCF activities . Positive_regulation CCND1 PRKAR2B 23571712 2838034 Finally , inhibition *attenuated* the effect of GLP-1 ( 28-36 ) amide on ß-cat Ser ( 675 ) phosphorylation and [cyclin D1] expression in the INS-1 cell line . Positive_regulation CCND1 PRKCA 12794082 1134014 Transient transfection studies with a series of 5'-deleted cyclin D1 promoter constructs showed that the proximal 964-base region , which contains AP-1 , SP1 , and CRE enhancer elements , is required for *activation* of the [cyclin D1] promoter by . Positive_regulation CCND1 PRKCA 12794082 1134015 Deletion of the AP-1 enhancer element located at position -954 upstream from the initiation site abolished *dependent* activation of [cyclin D1] expression . Positive_regulation CCND1 PRKCA 12794082 1134017 A dominant negative mutant of c-Jun inhibited activation of the cyclin D1 promoter in a concentration dependent manner , providing further evidence that AP-1 activity is required for *activation* of the [cyclin D1] promoter by and PKC-epsilon . Positive_regulation CCND1 PRKCA 20426528 2247183 The activation of with phorbol myristate acetate ( PMA ) , a PKC activator , *up-regulated* [cyclin D1] expression and increased the proliferation of passively sensitized HASMCs . Positive_regulation CCND1 PRKCA 22166648 2366566 Cigarette smoke extract promotes human pulmonary artery smooth muscle cells proliferation through *dependent* induction of [cyclin D1] . Positive_regulation CCND1 PRKCB 19182516 2038926 also *activates* [cyclin D1] via NFkappaB . Positive_regulation CCND1 PRKDC 23388457 2748206 We recently demonstrated that a moderate level of long-term fractionated radiation confers acquired radioresistance to tumor cells , which is caused by *mediated* [cyclin D1] overexpression . Positive_regulation CCND1 PRL 11356126 815588 In order to examine the mechanisms by which prolactin may exert trophic effects on its target tissues during development , we have examined the signalling pathways through which binding to the long receptor *regulates* the transcription of [cyclin D1] . Positive_regulation CCND1 PRL 11773438 899449 The expression of [cyclin D1] , a critical regulator of the G1/S transition , was significantly *increased* by and was associated with hyperphosphorylation of retinoblastoma protein at Ser ( 780 ) . Positive_regulation CCND1 PRL 11923474 926569 *activates* the [cyclin D1] promoter via the Jak2/Stat pathway . Positive_regulation CCND1 PRL 11923474 926570 also *increases* [cyclin D1] levels 2-fold , which can be inhibited by actinomycin D , suggesting that transcriptional increases in cyclin D1 are important . Positive_regulation CCND1 PRL 12907754 1157470 Moreover , we show that both c-Src/PI3K and c-Src/Fak/Erk1/2 pathways are involved in the up-regulation of c-myc and [cyclin d1] expression *mediated* by . Positive_regulation CCND1 PRL 15885880 1426563 This suggests a role for Oct-1 in *dependent* control of [cyclin D1] transcription . Positive_regulation CCND1 PRL 18403642 1893864 Insulin-like growth factor (IGF)-II is a required intermediate for induced *up-regulation* of [cyclin D1] and proliferation in normal murine mammary epithelial cells in vivo and in vitro . Positive_regulation CCND1 PRL 18403642 1893865 However , we have recently shown that can rapidly *induce* [cyclin D1] protein expression and subsequent proliferation in the MCF-7 human breast cancer cell line , suggesting that prolactin actions can be independent of IGFs in breast disease . Positive_regulation CCND1 PRL 18403642 1893870 Moreover , *increased* [cyclin D1] in the presence of the IGF-I receptor neutralizing antibody alphaIR3 . Positive_regulation CCND1 PRL 19169277 2043604 Finally , *induces* expression of c-Myc and [Cyclin D1] and leads to increased cell proliferation , which is specifically antagonized by ICI 182,780 or ERalpha depletion . Positive_regulation CCND1 PRL 20075866 2212455 Depletion of PIKE-A in HC11 epithelial cells diminished *induced* STAT5 activation and [cyclin D1] expression , resulting in profoundly impaired cell proliferation in vitro . Positive_regulation CCND1 PRL 21719533 2471262 PAK1-Nck regulates [cyclin D1] promoter activity in *response* to . Positive_regulation CCND1 PRL 21719533 2471266 [Cyclin D1] expression is directly *regulated* by through the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 5-mediated transcriptional activation of the cyclin D1 promoter . Positive_regulation CCND1 PRL 21719533 2471283 We have previously demonstrated that JAK2 directly phosphorylates PAK1 and extend these data here to demonstrate that PAK1 activates the [cyclin D1] promoter in *response* to . Positive_regulation CCND1 PRL 21719533 2471286 We show that mutation of PAK1 Tyr 153 , 201 , and 285 ( sites of JAK2 phosphorylation ; PAK1 Y3F ) decreases both PAK1 nuclear translocation in response to PRL and *induced* [cyclin D1] promoter activity by 55 % . Positive_regulation CCND1 PRL 21719533 2471290 Mutation of the PAK1 nuclear localization signals decreases *induced* [cyclin D1] promoter activity by 46 % . Positive_regulation CCND1 PRL 21719533 2471291 A PAK1 Y3F mutant lacking functional nuclear localization signals decreases *induced* [cyclin D1] activity by 68 % , suggesting that there is another PAK1 dependent mechanism to activate the cyclin D1 promoter . Positive_regulation CCND1 PRL 21719533 2471300 We propose two PAK1 dependent mechanisms to activate [cyclin D1] promoter activity in *response* to : via nuclear translocation of tyrosyl phosphorylated PAK1 and via formation of a Nck-PAK1 complex that sequesters PAK1 in the cytoplasm . Positive_regulation CCND1 PRL 22392353 2577222 The immunoblotting assay showed that *induced* the expression of both p-JAK2 and [cyclin D1] in Hep-G2 cells . Positive_regulation CCND1 PRL 9801809 543902 Estradiol ( E2 ) and human ( hPRL ) equally *enhanced* the [cyclin D1] gene expression in the cells , and 22 and 20 kDa human growth hormones ( 22K and 20K hGHs ) showed less stimulatory effects . Positive_regulation CCND1 PRSS8 19670249 2150667 *regulates* iNOS and [cyclin D1] expression by modulating protease activated receptor-2 signaling in prostate epithelial cells . Positive_regulation CCND1 PSEN2 18199582 1863524 expressed in the left ovarian primordium asymmetrically *upregulates* [cyclin D1] to stimulate cell proliferation . Positive_regulation CCND1 PSME3 24281003 2904557 Furthermore , miR-7 overexpression or silencing of *reduced* the [cyclinD1] expression at mRNA and protein level in NSCLC cell lines . Positive_regulation CCND1 PTEN 17438373 1729259 Here , we show that negatively *regulates* expression of [cyclin D1] and that cyclin D1 plays a unique role in p27 proteolysis . Positive_regulation CCND1 PTEN 23275086 2732630 Moreover , overexpression of could *induce* ASMCs arrested in the G0/G1 phase through the downregulation of [Cyclin D1] and upregulation of p21 expressions . Positive_regulation CCND1 PTGES3 9207452 440857 There was a correlation between activity , cell cycle status by BrdU incorporation , and *induction* of phosphorylated retinoblastoma protein , CDC2 , CDK2 , [cyclin D1] , and cyclin A , but not cyclin E and B1 after 72 hours with multiple ( but not single ) cytokines . Positive_regulation CCND1 PTGS2 15548426 1338404 activity *contributes* to neuronal expression of [cyclin D1] after anoxia/ischemia in vitro and in vivo . Positive_regulation CCND1 PTGS2 15548426 1338405 activity is known to induce expression of cyclin D1 in neoplastic cells , and [cyclin D1] expression can *induce* cell death in postmitotic neurons . Positive_regulation CCND1 PTGS2 15548426 1338407 These results show that activity is *required* for [cyclin D1] expression after ischemia in vivo and anoxia in vitro . Positive_regulation CCND1 PTGS2 17077316 1684057 The continued increase of ( up to 18 h ) *resulted* in increased intracellular prostaglandin E ( 2 ) and [cyclin D1] expression significantly after 8 and 12 h of EGF treatment . Positive_regulation CCND1 PTGS2 21152316 2356372 The expression of [cyclin D1] at the protein level was *detected* by immunohistochemistry , while protein expression was determined by Western blot . Positive_regulation CCND1 PTH 12198252 982186 Here we demonstrate that JMC mutations of the receptor induce *activation* of the [cyclin D1] and cyclin A promoters in primary mouse chondrocytes and rat chondrosarcoma cells . Positive_regulation CCND1 PTH 17501623 1761800 These data indicate that and PTHrP *induce* [cyclin D1] expression in early osteoblastic cells and their action is developmental stage specific . Positive_regulation CCND1 PTH 19107841 2024795 Studies of the effects of PTH on proteins involved in osteoblast precursor proliferation and apoptosis showed that *increased* [cyclinD1-cdk4/6] protein in Fgf2+/+ but not Fgf2-/- osteoblasts . Positive_regulation CCND1 PTHLH 12198252 982187 Here we demonstrate that JMC mutations of the receptor induce *activation* of the [cyclin D1] and cyclin A promoters in primary mouse chondrocytes and rat chondrosarcoma cells . Positive_regulation CCND1 PTHLH 17501623 1761797 *induced* a proliferative [cyclin D1] activation in low-density osteoblastic cells . Positive_regulation CCND1 PTHLH 17501623 1761801 These data indicate that PTH and *induce* [cyclin D1] expression in early osteoblastic cells and their action is developmental stage specific . Positive_regulation CCND1 PTHLH 23824099 2854234 Exogenous *induced* the expression of [cyclin D1] and Bcl-2 mRNA by various signalling pathways , whereas it inhibited Runx2 expression through PKA , p38MAPK , MEK and PI3K signalling pathways . Positive_regulation CCND1 PTX3 14500737 1144263 Indeed , is capable of blocking the membrane translocation of Akt , and enforced targeting of Akt to cell membrane *prevents* the inhibition of Akt and [cyclin D1] by PTX . Positive_regulation CCND1 PTX4 14500737 1144262 Indeed , is capable of blocking the membrane translocation of Akt , and enforced targeting of Akt to cell membrane *prevents* the inhibition of Akt and [cyclin D1] by PTX . Positive_regulation CCND1 PXN 20628053 2310216 Importantly , Erk mediated serine phosphorylation of is also *required* for DHT induced prostate-specific antigen mRNA expression in LnCAP cells as well as EGF induced [cyclin D1] mRNA expression in PC3 cells , suggesting that paxillin may regulate prostate cancer proliferation by serving as a liaison between extra-nuclear kinase signaling and intra-nuclear transcriptional signals . Positive_regulation CCND1 QRICH1 16892452 1783433 Azaserine , an inhibitor of : fruc-6-PO ( 4 ) amidotransferase ( GFAT ) in the HBP , *blocks* the HG-induced expression of laminin gamma1 and [cyclin D1] , but not GlcN 's effect because it exerts its metabolic function distal to GFAT . Positive_regulation CCND1 QRICH2 16892452 1783434 Azaserine , an inhibitor of : fruc-6-PO ( 4 ) amidotransferase ( GFAT ) in the HBP , *blocks* the HG-induced expression of laminin gamma1 and [cyclin D1] , but not GlcN 's effect because it exerts its metabolic function distal to GFAT . Positive_regulation CCND1 RAC1 10419529 631939 Activated PI 3-kinase *induces* [cyclin D(1)] transcription and E2F activity , at least in part mediated by the serine/threonine kinase Akt/PKB , and to a lesser extent the Rho family GTPase . Positive_regulation CCND1 RAC1 10464245 640336 Integration of *dependent* regulation of [cyclin D1] transcription through a nuclear factor-kappaB dependent pathway . Positive_regulation CCND1 RAC1 10464245 640343 *Induction* of [cyclin D1] by required both an NF-kappaB and an ATF-2 binding site . Positive_regulation CCND1 RAC1 10464245 640362 Activation of in NIH 3T3 cells induces both NF-kappaB binding and activity and *enhances* expression of [cyclin D1] through an NF-kappaB and ATF-2 site in the proximal promoter , suggesting a critical role for NF-kappaB in cell cycle regulation through cyclin D1 and Rac1 . Positive_regulation CCND1 RAC1 11017907 737623 We next examined whether PI 3-kinase and the 21-kD guanidine triphosphatase *regulate* [cyclin D(1)] promoter activity by similar mechanisms . Positive_regulation CCND1 RAC1 11017907 737630 Further , PDGF , PI 3-kinase , and each *activated* the [cyclin D(1)] promoter at the cyclic adenosine monophosphate response element binding protein ( CREB ) /activating transcription factor (ATF)-2 binding site , as evidenced by expression of a CREB/ATF-2 reporter plasmid . Positive_regulation CCND1 RAC1 11715015 881616 Thus , [cyclin D1] is *induced* in mid-G1 phase because a Rho switch couples its expression to sustained ERK activity rather than and Cdc42 . Positive_regulation CCND1 RAC1 12773570 1095225 Inhibition of either MLCK or Rho kinase blocked sustained ERK signaling , but only Rho kinase inhibition allowed for the induction of [cyclin D1] and *activation* of cdk4 via . Positive_regulation CCND1 RAC1 12919678 1130866 Surprisingly , inhibition of *dependent* [cyclin D1] expression by LIM kinase is independent of both cofilin phosphorylation and actin polymerization . Positive_regulation CCND1 RAC1 12919678 1130872 Instead , specific mutation of its nuclear localization and export sequences showed that LIM kinase acts in the nucleus to suppress *dependent* [cyclin D1] expression . Positive_regulation CCND1 RAC1 15377999 1323916 Furthermore , we show that [Cyclin D1] , an important biological Wnt target gene , is *regulated* by in a beta-catenin/TCF dependent manner . Positive_regulation CCND1 RAC1 15817154 1393352 We show that , in contrast to Rac1 , expression of wild-type is *sufficient* to stimulate [cyclin D1] accumulation and G1/S progression in these cells . Positive_regulation CCND1 RAC1 17426454 1736482 In this report we characterize the mechanism of *mediated* [cyclin D1] gene expression in mouse embryonic fibroblasts . Positive_regulation CCND1 RAC1 17426454 1736485 Activated strongly *stimulated* [cyclin D1] gene transcription but did not alter the half-life of cyclin D1 mRNA . Positive_regulation CCND1 RAC1 17426454 1736495 Moreover , mouse cyclin D1 promoter-luciferase assays showed that *stimulated* [cyclin D1] gene expression without activating NFkappaB and that an essential Rac regulated promoter element is located far upstream or downstream of the cyclin D1 transcription start site . Positive_regulation CCND1 RAC1 17426454 1736498 We conclude that , in MEFs , mediated induction of cyclin D1 mRNA *requires* activation of a parallel NFkappaB pathway whereas ERK induces [cyclin D1] transcription independent of NFkappaB . Positive_regulation CCND1 RAC1 17941827 1849401 Heregulin beta1 promotes breast cancer cell proliferation through dependent *induction* of [cyclin D1] and p21Cip1 . Positive_regulation CCND1 RAC1 18187454 1856828 *dependent* [cyclin D1] gene expression regulated by cadherin- and integrin mediated adhesion . Positive_regulation CCND1 RAC1 18187454 1856837 Our previous studies described a pro-proliferative effect of E-cadherin in MCF10A cells , mediated by Rac , and we now show that is *required* for [cyclin D1] mRNA induction by both E-cadherin and integrin engagement . Positive_regulation CCND1 RAC1 18715870 1979815 Overall , our results reveal two mechanistically distinct phases of *dependent* [cyclin D1] expression and emphasize that the acquisition of Rac/ERK co-dependence is required for the mid-G1 phase induction of cyclin D1 associated with S phase entry . Positive_regulation CCND1 RAC1 19765988 2140729 In contrast , FAK dependent Rac activation , *dependent* [cyclin D1] gene induction , and cyclin D1-dependent Rb phosphorylation are strongly inhibited at physiological tissue stiffness and rescued when the matrix is stiffened in vitro . Positive_regulation CCND1 RAC1 20515940 2270988 In MDA-MB-231 cells , inhibition *induced* G ( 1 ) cell cycle arrest through downregulation of [cyclin D1] and subsequent dephosphorylation/inactivation of Rb . Positive_regulation CCND1 RAC1 23664830 2853819 A inhibitor , NSC23766 , also *inhibited* cell proliferation , and both apocynin and NSC23766 reduced phosphorylation of Rac1 and NF-?B , as well as [cyclin D1] . Positive_regulation CCND1 RAC1 23737530 2819888 Thus , these observations reveal that Pak1 is a downstream effector of CDK4 and *dependent* , NFATc1 mediated [cyclin D1] expression and CDK6 activity mediate this effect . Positive_regulation CCND1 RAC1 9488437 488745 Fifth , Mas and *stimulated* transcription from common DNA promoter elements : NF-kappaB , serum response factor (SRF) , Jun/ATF-2 , and the [cyclin D1] promoter . Positive_regulation CCND1 RAC2 10419529 631940 Activated PI 3-kinase *induces* [cyclin D(1)] transcription and E2F activity , at least in part mediated by the serine/threonine kinase Akt/PKB , and to a lesser extent the Rho family GTPase . Positive_regulation CCND1 RAC2 10464245 640337 Integration of *dependent* regulation of [cyclin D1] transcription through a nuclear factor-kappaB dependent pathway . Positive_regulation CCND1 RAC2 11715015 881617 Thus , [cyclin D1] is *induced* in mid-G1 phase because a Rho switch couples its expression to sustained ERK activity rather than and Cdc42 . Positive_regulation CCND1 RAC2 12773570 1095226 Inhibition of either MLCK or Rho kinase blocked sustained ERK signaling , but only Rho kinase inhibition allowed for the induction of [cyclin D1] and *activation* of cdk4 via . Positive_regulation CCND1 RAC2 12919678 1130867 Surprisingly , inhibition of *dependent* [cyclin D1] expression by LIM kinase is independent of both cofilin phosphorylation and actin polymerization . Positive_regulation CCND1 RAC2 12919678 1130873 Instead , specific mutation of its nuclear localization and export sequences showed that LIM kinase acts in the nucleus to suppress *dependent* [cyclin D1] expression . Positive_regulation CCND1 RAC2 17426454 1736483 In this report we characterize the mechanism of *mediated* [cyclin D1] gene expression in mouse embryonic fibroblasts . Positive_regulation CCND1 RAC2 17426454 1736486 Activated strongly *stimulated* [cyclin D1] gene transcription but did not alter the half-life of cyclin D1 mRNA . Positive_regulation CCND1 RAC2 17426454 1736496 Moreover , mouse cyclin D1 promoter-luciferase assays showed that *stimulated* [cyclin D1] gene expression without activating NFkappaB and that an essential Rac regulated promoter element is located far upstream or downstream of the cyclin D1 transcription start site . Positive_regulation CCND1 RAC2 17426454 1736499 We conclude that , in MEFs , mediated induction of cyclin D1 mRNA requires activation of a parallel NFkappaB pathway whereas ERK *induces* [cyclin D1] transcription independent of NFkappaB . Positive_regulation CCND1 RAC2 17941827 1849402 Heregulin beta1 promotes breast cancer cell proliferation through *dependent* induction of [cyclin D1] and p21Cip1 . Positive_regulation CCND1 RAC2 18187454 1856829 *dependent* [cyclin D1] gene expression regulated by cadherin- and integrin mediated adhesion . Positive_regulation CCND1 RAC2 18187454 1856838 Our previous studies described a pro-proliferative effect of E-cadherin in MCF10A cells , mediated by Rac , and we now show that is *required* for [cyclin D1] mRNA induction by both E-cadherin and integrin engagement . Positive_regulation CCND1 RAC2 18715870 1979816 Overall , our results reveal two mechanistically distinct phases of *dependent* [cyclin D1] expression and emphasize that the acquisition of Rac/ERK co-dependence is required for the mid-G1 phase induction of cyclin D1 associated with S phase entry . Positive_regulation CCND1 RAC2 19765988 2140730 In contrast , FAK dependent Rac activation , dependent cyclin D1 gene *induction* , and [cyclin D1-dependent] Rb phosphorylation are strongly inhibited at physiological tissue stiffness and rescued when the matrix is stiffened in vitro . Positive_regulation CCND1 RAC3 10419529 631941 Activated PI 3-kinase *induces* [cyclin D(1)] transcription and E2F activity , at least in part mediated by the serine/threonine kinase Akt/PKB , and to a lesser extent the Rho family GTPase . Positive_regulation CCND1 RAC3 10464245 640338 Integration of *dependent* regulation of [cyclin D1] transcription through a nuclear factor-kappaB dependent pathway . Positive_regulation CCND1 RAC3 11715015 881618 Thus , [cyclin D1] is *induced* in mid-G1 phase because a Rho switch couples its expression to sustained ERK activity rather than and Cdc42 . Positive_regulation CCND1 RAC3 12773570 1095227 Inhibition of either MLCK or Rho kinase blocked sustained ERK signaling , but only Rho kinase inhibition allowed for the induction of [cyclin D1] and *activation* of cdk4 via . Positive_regulation CCND1 RAC3 12919678 1130868 Surprisingly , inhibition of *dependent* [cyclin D1] expression by LIM kinase is independent of both cofilin phosphorylation and actin polymerization . Positive_regulation CCND1 RAC3 12919678 1130874 Instead , specific mutation of its nuclear localization and export sequences showed that LIM kinase acts in the nucleus to suppress *dependent* [cyclin D1] expression . Positive_regulation CCND1 RAC3 17426454 1736484 In this report we characterize the mechanism of *mediated* [cyclin D1] gene expression in mouse embryonic fibroblasts . Positive_regulation CCND1 RAC3 17426454 1736487 Activated strongly *stimulated* [cyclin D1] gene transcription but did not alter the half-life of cyclin D1 mRNA . Positive_regulation CCND1 RAC3 17426454 1736497 Moreover , mouse cyclin D1 promoter-luciferase assays showed that *stimulated* [cyclin D1] gene expression without activating NFkappaB and that an essential Rac regulated promoter element is located far upstream or downstream of the cyclin D1 transcription start site . Positive_regulation CCND1 RAC3 17426454 1736500 We conclude that , in MEFs , mediated induction of cyclin D1 mRNA *requires* activation of a parallel NFkappaB pathway whereas ERK induces [cyclin D1] transcription independent of NFkappaB . Positive_regulation CCND1 RAC3 17941827 1849403 Heregulin beta1 promotes breast cancer cell proliferation through dependent *induction* of [cyclin D1] and p21Cip1 . Positive_regulation CCND1 RAC3 18187454 1856830 *dependent* [cyclin D1] gene expression regulated by cadherin- and integrin mediated adhesion . Positive_regulation CCND1 RAC3 18187454 1856839 Our previous studies described a pro-proliferative effect of E-cadherin in MCF10A cells , mediated by Rac , and we now show that is *required* for [cyclin D1] mRNA induction by both E-cadherin and integrin engagement . Positive_regulation CCND1 RAC3 18715870 1979817 Overall , our results reveal two mechanistically distinct phases of *dependent* [cyclin D1] expression and emphasize that the acquisition of Rac/ERK co-dependence is required for the mid-G1 phase induction of cyclin D1 associated with S phase entry . Positive_regulation CCND1 RAC3 19765988 2140731 In contrast , FAK dependent Rac activation , *dependent* [cyclin D1] gene induction , and cyclin D1-dependent Rb phosphorylation are strongly inhibited at physiological tissue stiffness and rescued when the matrix is stiffened in vitro . Positive_regulation CCND1 RAD1 20460530 2268765 Furthermore , in the *presence* of , GCIP loses its ability to reduce retinoblastoma phosphorylation and inhibit [cyclin D1] activity . Positive_regulation CCND1 RAD17 20460530 2268766 Furthermore , in the *presence* of , GCIP loses its ability to reduce retinoblastoma phosphorylation and inhibit [cyclin D1] activity . Positive_regulation CCND1 RAD18 20460530 2268764 Furthermore , in the *presence* of , GCIP loses its ability to reduce retinoblastoma phosphorylation and inhibit [cyclin D1] activity . Positive_regulation CCND1 RAD21 20460530 2268767 Furthermore , in the *presence* of , GCIP loses its ability to reduce retinoblastoma phosphorylation and inhibit [cyclin D1] activity . Positive_regulation CCND1 RAD50 20460530 2268768 Furthermore , in the *presence* of , GCIP loses its ability to reduce retinoblastoma phosphorylation and inhibit [cyclin D1] activity . Positive_regulation CCND1 RAD51 20460530 2268769 Furthermore , in the *presence* of , GCIP loses its ability to reduce retinoblastoma phosphorylation and inhibit [cyclin D1] activity . Positive_regulation CCND1 RAD51 21654808 2442178 We found that [cyclin D1] directly binds RAD51 , and that cyclin interaction is *induced* by radiation . Positive_regulation CCND1 RAD51 24830723 2945119 [Cyclin D1] was recruited to ?H2AX foci by E2 and *induced* expression . Positive_regulation CCND1 RAD52 20460530 2268770 Furthermore , in the *presence* of , GCIP loses its ability to reduce retinoblastoma phosphorylation and inhibit [cyclin D1] activity . Positive_regulation CCND1 RAF1 12893773 1157320 These events were accompanied by down-regulation of the *induced* extracellular kinase ( MEK ) /extracellular signal related kinase ( ERK ) pathway as well as diminished expression of Bcr/Abl and [cyclin D1] , cleavage of p21CIP1 and phosphorylation of the retinoblastoma protein ( pRb ) , and induction of the stress related kinases Jun kinase (JNK) and p38 mitogen activated protein kinase (MAPK) . Positive_regulation CCND1 RAF1 9111327 425688 The activation of the protein *leads* to an accumulation of high levels of [cyclin D1] protein and a repression of the p27Kip1 cyclin dependent kinase inhibitor under all culture conditions tested . Positive_regulation CCND1 RALA 11027278 738767 Here we show that expression of activated in quiescent rodent fibroblasts is *sufficient* to induce activation of NF-kappaB dependent gene expression and [cyclin D1] transcription , two key convergence points for mitogenic and survival signaling . Positive_regulation CCND1 RALA 11027278 738776 Ral activation of these responses is likely through an as yet uncharacterized effector pathway , as we find *activation* of NF-kappaB and the [cyclin D1] promoter by is independent of association of Ral with active phospholipase D1 or Ral binding protein 1 , two proteins proposed to mediate Ral function in cells . Positive_regulation CCND1 RANBP9 24312406 2877951 More specifically , functional interaction of with either BM88/Cend1 or Dyrk1B *stabilizes* [cyclin D1] in the nucleus and promotes 5-bromo-2'-deoxyuridine ( BrdU ) incorporation as a measure of enhanced cell proliferation . Positive_regulation CCND1 RB1 10843991 721991 [Cyclin D1] protein expression is regulated by mitogens , and its assembly with the cyclin dependent kinases *induces* phosphorylation of the retinoblastoma protein , a critical step in G ( 1 ) to S phase cell cycle progression contributing to the proliferative responses . Positive_regulation CCND1 RB1 21478909 2475528 In addition , depletion of ARF1 or expression of ARF1T ( 31 ) N resulted in the constitutive association of and E2F1 , thereby stabilizing the interaction of E2F1 as well as pRB at endogenous sites of target gene promoters , *preventing* expression of E2F target genes , such as [cyclin D1] , Mcm6 and E2F1 , important for cell-cycle progression . Positive_regulation CCND1 RB1 8175885 255743 Extending the current view of the emerging functional interplay between pRB and D-type cyclins , we now report that [cyclin D1] expression is positively *regulated* by . Positive_regulation CCND1 RB1 8552398 347204 Cyclin D1 can bind and phosphorylate the product ( pRb ) of the retinoblastoma gene ( RB-1 ) and recent evidence suggests , in turn , may *regulate* [cyclin D1] protein expression . Positive_regulation CCND1 RB1 8552398 347208 We show here that does not *regulate* [cyclin D1] directly as basal and serum stimulated levels of cyclin D1 protein and kinase activity are similar in wildtype and pRb-deficient primary mouse embryonic fibroblasts ( MEFs ) . Positive_regulation CCND1 RB1 8552398 347210 These observations suggest that the suppression of [cyclin D1] in pRb-minus tumour cell lines *requires* both loss of and at least one additional genetic event . Positive_regulation CCND1 RBBP4 21233448 2402671 Furthermore , inhibition *repressed* mitogen induced [cyclin D1] mRNA expression and cyclin D1 promoter activity . Positive_regulation CCND1 RBBP4 21465537 2448223 Inhibition of activity with trichostatin A (TSA) , *blocked* cell proliferation , decreased expression of [Cyclin D1] , a positive cell cycle regulator , and increased expression of p27 and p57 , two negative cell cycle regulators . Positive_regulation CCND1 RBBP7 21233448 2402672 Furthermore , inhibition *repressed* mitogen induced cyclin D1 mRNA expression and [cyclin D1] promoter activity . Positive_regulation CCND1 RBBP7 21465537 2448224 Inhibition of activity with trichostatin A (TSA) , *blocked* cell proliferation , decreased expression of [Cyclin D1] , a positive cell cycle regulator , and increased expression of p27 and p57 , two negative cell cycle regulators . Positive_regulation CCND1 RBBP8 16581787 1543864 *activates* its own and [cyclin D1] promoters via the E2F/RB pathway during G1/S progression . Positive_regulation CCND1 REG3A 20489047 2294751 Overexpressed *increased* [cyclin D1] and CDK4 levels and the rate of proliferation in insulinoma cells . Positive_regulation CCND1 REG4 24151146 2916319 As assessed by real-time RT-PCR and Western blot analyses , significantly *increased* the expression of cell cycle regulatory genes [Cyclin D1] and D3 , and associated Cyclin dependent kinases ( CDK4 and CDK6 ) . Positive_regulation CCND1 REL 12897145 1118155 Lastly , stable overexpression of *resulted* in increased [cyclin D1] and NF-kappaB p52 and p50 subunit protein levels . Positive_regulation CCND1 RELA 10082535 597787 Moreover , inhibition of *caused* a pronounced reduction of serum induced [cyclin D1-associated] kinase activity and resulted in delayed phosphorylation of the retinoblastoma protein . Positive_regulation CCND1 RELA 10409765 630552 An analysis of cell cycle markers revealed that *activates* [cyclin D1] expression , and the results showed that this regulatory pathway is one mechanism by which NF-kappaB inhibits myogenesis . Positive_regulation CCND1 RELA 10409765 630554 NF-kappaB regulation of [cyclin D1] occurs at the transcriptional level and is *mediated* by direct binding of to multiple sites in the cyclin D1 promoter . Positive_regulation CCND1 RELA 10409765 630560 Using diploid fibroblasts , we demonstrate that is *required* to induce [cyclin D1] expression and pRb hyperphosphorylation and promote G ( 1 ) -to-S progression . Positive_regulation CCND1 RELA 10464245 640344 Induction of [cyclin D1] by Rac1 *required* both an and an ATF-2 binding site . Positive_regulation CCND1 RELA 11027278 738768 Here we show that expression of activated Ral in quiescent rodent fibroblasts is sufficient to induce activation of *dependent* gene expression and [cyclin D1] transcription , two key convergence points for mitogenic and survival signaling . Positive_regulation CCND1 RELA 11027278 738772 The regulation of [cyclin D1] transcription by Ral is *dependent* on activation and is mediated through an NF-kappaB binding site in the cyclin D1 promoter . Positive_regulation CCND1 RELA 11747812 889407 IKKalpha and activation are also *required* for optimal [cyclin D1] induction . Positive_regulation CCND1 RELA 11861406 917204 Expressions of Cyclin B1 , [Cyclin D1] , and HIAP were *down-regulated* by the inhibition of . Positive_regulation CCND1 RELA 11992406 938697 Inhibitors of ( dominant negative IkappaBs mutants ) *suppressed* Tax dependent activation of [cyclin D1] and D2 promoters , indicating that Tax induced activation was mediated by NF-kappaB . Positive_regulation CCND1 RELA 12907607 1119205 The inhibition of NF-kappaB activation correlated with suppression of *dependent* [cyclin D1] , cyclooxygenase 2 , and matrix metalloproteinase 9 expression . Positive_regulation CCND1 RELA 15131058 1245555 The inhibition of activation correlated with a decreased expression of NF-kappaB dependent reporter gene and *suppressed* expression of NF-kappaB regulated genes [ specifically , Bcl2 , [cyclin D1] , cyclooxygenase-2 , matrix metalloproteinase 9 , nitric oxide synthase-2 (NOS-2) , and vascular endothelial growth factor ] . Positive_regulation CCND1 RELA 15798085 1451617 Moreover , inhibition of *caused* a pronounced reduction of EGF induced [cyclin D1] promoter activity . Positive_regulation CCND1 RELA 15893541 1407601 To determine whether the NNK induced activation and [cyclin D1] *induction* were also observed in vivo , A/J mice were treated with NNK ( 9.1 mg ) for 20 weeks and the results showed a significant induction of cyclin D1 and NFkappaB translocation determined by immunoblotting analyses . Positive_regulation CCND1 RELA 16230390 1470078 The induction of [cyclin D1] by arsenite *required* activation , because the inhibition of IkappaB phosphorylation by overexpression of the dominant negative mutant , IKKbeta-KM , impaired arsenite induced cyclin D1 expression and G1-S transition . Positive_regulation CCND1 RELA 16231352 1476744 The underlying molecular mechanism was associated with increased inhibitor of nuclear factor-kappa B alpha ( IkappaBalpha ) expression , which inhibited activation and *induction* of its target genes , [cyclin D1] and Bcl-xL , increasing sensitivity to apoptosis initiated by elevated tumor necrosis factor-alpha . Positive_regulation CCND1 RELA 16322332 1487937 Although TNFalpha was poorly effective in increasing cyclin D1 expression , blockade by the specific inhibitor BAY11-7082 *reduced* FCS stimulated [cyclin D1] by about 60 % . Positive_regulation CCND1 RELA 16331275 1526285 We have found that TNF-alpha exerts a mitogenic effect , inducing [cyclin D1] expression and *activation* of the transcription factor . Positive_regulation CCND1 RELA 16331275 1526287 Importantly , activation of was *required* for estrogen induced proliferation and [cyclin D1] expression . Positive_regulation CCND1 RELA 16481354 1528468 We show that activation is *essential* for induction of Shh and [cyclin D1] expression and subsequent placode down growth . Positive_regulation CCND1 RELA 16759223 1631482 AP1 and cAMP response element ( CRE ) , but not , were *involved* in the induced [cyclin D1] expression . Positive_regulation CCND1 RELA 16940298 1627452 Up-regulation of [cyclin D1] by HBx is *mediated* by complex through kappaB site of cyclin D1 promoter . Positive_regulation CCND1 RELA 16963181 1700239 Furthermore , rugosin E also inhibited the TNF-alpha activated *dependent* reporter gene expression of [cyclin D1] , c-Myc , XIAP , Bcl-2 , and Bcl-X ( L ) were all downregulated by rugosin E . Positive_regulation CCND1 RELA 17385714 1727712 These findings suggest that activation *stimulates* [cyclin D1] expression and triggers DNA replication in striatal neurons . Positive_regulation CCND1 RELA 18160626 1869292 Consequently , the inhibition of Ca ( 2+ ) , PKC , EGFR , p44/42 MAPKs , or *blocked* the BSA induced increases in [cyclin D1] , cyclin dependent kinase (CDK)4 , cyclin E , or CDK2 and restored the BSA induced inhibition of p21 ( WAF/Cip1 ) and p27 ( Kip1 ) expression . Positive_regulation CCND1 RELA 19263436 2135398 In this article , we found that Degenerative Spermatocyte Homolog 1 ( DEGS1 ) up-regulated the expression of cyclin D1 and the activation of transcription factor was *essential* for DEGS1 induced [cyclin D1] production . Positive_regulation CCND1 RELA 19551842 2208794 This was associated with significantly lower proliferating cell nuclear antigen positive hepatocytes and [cyclinD1] protein , as well as decreased *activation* of extracellular signal regulated kinase and nuclear . Positive_regulation CCND1 RELB 16260626 1478091 complexes *induced* [cyclin D1] and c-myc promoter activities and failed in electrophoretic mobility shift assay to interact with IkappaB-alpha-glutathione S-transferase , indicating that their weak interaction with IkappaB-alpha can account for the observed recovery of mammary gland development . Positive_regulation CCND1 RELB 16260626 1478098 Inhibition of in breast cancer cells *repressed* [cyclin D1] and c-Myc levels and growth in soft agar . Positive_regulation CCND1 RENBP 11684565 874442 We found that *increased* [cyclin D1] expression and cyclin dependent kinase (cdk)4 activity while decreasing p21 ( WAF1/CIP1 ) expression . Positive_regulation CCND1 RENBP 11684565 874447 In addition , STAT5 decoy ODN reversed *induced* cell-cycle dependent cellular proliferation and [cyclin D1] protein expression . Positive_regulation CCND1 RENBP 17466927 1731960 also *increased* tyrosine phosphorylation of Hsp70 , cyclin E , and [cyclin D1] ( to a lesser extent ) while increasing Hsp70 protein interactions with STAT1 , STAT3 , STAT5b , cyclin D1 , and cyclin E. AGE induced tyrosine phosphorylation of Hsp70 and cyclin E ( but not cyclin D1 ) was attenuated by AG-490 . Positive_regulation CCND1 RENBP 17466927 1731962 *induced* mitogenesis , [cyclin D1] , and cyclin E were attenuated by Hsp70 antisense oligodeoxynucleotide and 2-aminopurine ( an Hsp70 inhibitor ) . Positive_regulation CCND1 RETN 18199582 1863523 expressed in the left ovarian primordium asymmetrically *upregulates* [cyclin D1] to stimulate cell proliferation . Positive_regulation CCND1 RGL2 10419529 632015 In addition , both activated and Raf *stimulate* [cyclin D(1)] transcription and E2F activity and act in synergy with PI 3-kinase . Positive_regulation CCND1 RHO 10611246 656155 Induction of [cyclin D1] by NeuT *involved* Ras , Rac , , extracellular signal regulated kinase , c-Jun N-terminal kinase , and p38 , but not phosphatidylinositol 3-kinase . Positive_regulation CCND1 RHO 11896588 922797 *regulates* p21 ( CIP1 ) , [cyclin D1] , and checkpoint control in mammary epithelial cells . Positive_regulation CCND1 RHO 11896588 922812 Our results demonstrate that Rho plays a fundamental role in promoting Ras dependent S phase entry in mammary epithelial cells , whether in response to normal or oncogenic signaling , and indicate that in cells expressing oncogenic Ras , the activation of diminishes p21 ( CIP1 ) expression , *increases* [cyclin D1] promoter activity , and uncouples DNA synthesis from mitosis . Positive_regulation CCND1 RHO 12773570 1095231 Overall , our results indicate that kinase dependent stress fiber formation is *required* for sustained activation of the MEK/ERK pathway and the mid-G ( 1 ) phase induction of [cyclin D1] , but not for other aspects of cdk4 or cdk2 activation . Positive_regulation CCND1 RHO 15840582 1418281 GTPase dependent signaling is *required* for macrophage migration inhibitory factor mediated expression of [cyclin D1] . Positive_regulation CCND1 RHO 15840582 1418284 dependent stress fiber accumulation *promotes* the sustained activation of ERK and subsequent [cyclin D1] expression during G ( 1 ) -S phase cell cycle progression . Positive_regulation CCND1 RHOA 11896588 922810 In addition , C3 blocked EGF stimulated cyclin D1 promoter activity whereas *induced* the [cyclin D1] promoter and cooperated with V12Ras in cyclin D1 induction . Positive_regulation CCND1 RHOA 15705584 1395680 STAT3 was required for the *induced* NF-kappaB and [cyclin D1] transcription and was involved in NF-kappaB nuclear translocation . Positive_regulation CCND1 RHOA 9407076 470804 Ras stimulated extracellular signal related kinase 1 and activities coordinate platelet derived growth factor *induced* G1 progression through the independent regulation of [cyclin D1] and p27 . Positive_regulation CCND1 RHOA 9407076 470825 Overexpression of dominant negative forms of Ras or completely blocked PDGF induced p27 ( KIP1 ) degradation , but only dominant negative Ras *inhibited* [cyclin D1] protein expression . Positive_regulation CCND1 RIN1 15511088 1328205 In contrast , expression of : delta , a natural splice variant of Rin1 lacking 47 amino acids in the Vps9p domain or Rab5 , *increase* both activation of Raf-Erk1/2- and [cyclin D1] transcription in response to EGF . Positive_regulation CCND1 RPAP1 15226187 1301797 Our results suggest a model where bound at IgH regulatory sequences can *activate* the [cyclin D1] promoter by either long-range polymerase transfer or tracking . Positive_regulation CCND1 RPL19 19799608 2209141 In addition , the suppression of expression by transfection with small interfering RNA *resulted* in the suppression of [cyclinD1] , D3 synthesis , and the growth inhibition of lung cancer cell lines overexpressing RPL19 . Positive_regulation CCND1 RPS6KA1 19470470 2091090 overexpression *increases* p27pT198 , [p27-cyclin D1-Cdk4] complexes , and p27 stability . Positive_regulation CCND1 RPS6KB1 19065636 2024063 Overexpression of the kinase dead form of S6K1 containing the mutation Lys 100 -- > Gln in PMA induced Dami cells increased ploidy whereas overexpression of rapamycin-resistant form of containing the mutations Thr421 -- > Glu and Ser424 -- > Asp significantly dephosphorylated 4E-BP1 and *reduced* expression of [cyclin D1] , cyclin D3 , p21 and p27 , and slightly decreased the ploidy of PMA induced Dami cells , compared with treatment with PMA alone . Positive_regulation CCND1 RRM2B 21216934 2386384 Conversely , overexpression of *resulted* in an increase in the expression of p21 and decrease in the expression of [cyclin D1] , which correlated with reduced cell population in S-phase in vitro and suppressed growth in vivo . Positive_regulation CCND1 RUNX2 19351720 2064793 We recently demonstrated that [cyclin D1] *induces* protein phosphorylation and degradation . Positive_regulation CCND1 S100A6 16123159 1467038 MPA *increased* both the protein level ( 2.2-fold induction ) and promoter activity ( 2.7-fold induction ) of [cyclin D1] in MCF-7 cells transfected with PRB but not with . Positive_regulation CCND1 S100A8 16759223 1631479 Mechanisms for Helicobacter pylori *induced* [cyclin D1] expression that affect cell cycle . Positive_regulation CCND1 SETD2 23455892 2713958 [CCND1] ( cyclin D1 ) expression could be *regulated* by PPAR? and via the cell cycle pathway . Positive_regulation CCND1 SFN 16170570 1500432 Furthermore , the activation of the ERK and p38 pathways by is *involved* in the upregulation of p21 ( CIP1 ) and [cyclin D1] , whereas the activation of the JNK pathway plays a contradictory role and may be partially involved in the downregulation of cyclin D1 . Positive_regulation CCND1 SH3D19 18355957 1912640 Down-regulation of expression in MCF-7 cells by shRNA *resulted* in increased cell growth in response to HRG and increased [cyclin D1] and ErbB2 expression . Positive_regulation CCND1 SHH 12361972 995086 By contrast , we show that is *required* for [cyclin D1] expression and the subsequent growth of both ventral and dorsal regions of the diencephalon and midbrain in early somite-stage mouse embryos . Positive_regulation CCND1 SHH 20720195 2306789 Inhibition of signaling in hVSMCs through treatment with cyclopamine or knockdown of Gli2 results in G ( 1 ) arrest and *reduced* [cyclin D1] , cyclin E , and phosphorylated retinoblastoma (pRB) levels . Positive_regulation CCND1 SIAH1 19091460 2041991 The hexachlorophene modulation of and beta-catenin is independent of p53 and *results* in reduced expression of [cyclin-D1] and c-Myc ( target genes of beta-catenin ) , leading to the growth arrest of B lymphoma cells . Positive_regulation CCND1 SIX1 23636126 2810566 The AP-1 mutation did not affect *dependent* activation of [cyclin D1] . Positive_regulation CCND1 SIX1 24114014 2926459 Results showed that could *increase* the expression of [cyclin D1] and VEGF-C , and decrease the expression of caspase-3 . Positive_regulation CCND1 SKP2 15585645 1345663 [Cyclin D1] degradation *involved* , a regulatory component of the Skp1/Cullin/F-box complex ; Positive_regulation CCND1 SLC12A9 15640940 1349799 The proliferation arrest was accompanied by a decrease in [cyclin D1] expression and the *activation* of and p27Kip1 pathways in both cell lines . Positive_regulation CCND1 SLC12A9 21312237 2398651 WIN 55,212-2 also upregulated phospho-ERK1/2 , *induced* Kip1/p27 and expression , decreased [cyclin D1] and cyclin E expression , decreased Cdk 2 , Cdk 4 , and Cdk 6 expression levels , and decreased phospho-Rb and E2F-1 expression . Positive_regulation CCND1 SLC12A9 21575346 2430306 At the saccular stage , the expression of [CyclinD1] decreased significantly and the expression *increased* significantly . Positive_regulation CCND1 SLC20A1 20709201 2330123 These results suggest that signaling by extracellular Pi is mediated by and FRS2a , and *leads* to activation of the Raf/MEK/ERK pathway and increased expression of [cyclin D1] , which facilitates the proliferation of immature chondrocytes . Positive_regulation CCND1 SLC38A3 12606305 1091818 In addition , we found that *induced* a significant increase in the levels of [cyclin D1] transcripts , protein , and promoter activity . Positive_regulation CCND1 SLPI 12023969 968100 selectively *increased* [cyclin D1] gene expression , with the effect occurring in part at the level of promoter activity . Positive_regulation CCND1 SMAD7 15922743 1413837 *inhibits* TGF-beta mediated downregulation of c-Myc , CDK4 , and [Cyclin D1] , and suppresses the expression of p21 ( Cip1 ) . Positive_regulation CCND1 SMARCB1 18556204 1934819 Loss of *results* in aberrant expression of [Cyclin D1] , which supports rhabdoid tumorigenesis and survival . Positive_regulation CCND1 SMO 16815712 1586073 expression *promoted* a cell-autonomous increase in [CyclinD1] expression and RPC proliferation and promoted the development of cells with an inner nuclear layer identity . Positive_regulation CCND1 SNAI2 22801439 2628655 *regulates* [Cyclin D1] expression by ubiquitin-proteasome pathway in prostate cancer cells . Positive_regulation CCND1 SNAI2 22801439 2628657 And *regulates* [cyclin D1] expression by ubiquitin-proteasome pathway in PCa cells . Positive_regulation CCND1 SNIP1 17260016 1765564 Moreover , we have demonstrated previously that *regulates* [cyclin D1] expression and promoter activity . Positive_regulation CCND1 SOX17 19479035 2085723 Notably , enhanced cyclin D1 expression in vivo and *activated* [cyclin D1] promoter activity in vitro . Positive_regulation CCND1 SOX4 21165564 2373484 *increased* the protein level of ß-catenin and its target gene [cyclin D1] in a dose dependent manner . Positive_regulation CCND1 SP1 17617380 1769540 Arsenic trioxide mediated growth inhibition in gallbladder carcinoma cells via down-regulation of [Cyclin D1] transcription *mediated* by . Positive_regulation CCND1 SP1 18367547 1912791 Nerve Growth factor regulation of [cyclin D1] in PC12 cells through a p21RAS extracellular signal regulated kinase pathway *requires* cooperative interactions between and nuclear factor-kappaB . Positive_regulation CCND1 SPAG9 24740566 2943394 In addition , we found that could *regulate* [cyclin D1] and cyclin E protein expression . Positive_regulation CCND1 SPESP1 22200963 2599709 The results indicated that promoted myoblast proliferation in a dose dependent manner and *increased* the expression of the cell-cycle regulator [cyclin D1] as well as that of proliferating cell nuclear antigen ( PCNA ) . Positive_regulation CCND1 SPHK1 17164439 1717000 Overexpressing human in these cells *resulted* in increased levels of the cell cycle regulator [cyclin D1] and increased myosin light-chain phosphorylation . Positive_regulation CCND1 SRC 10688905 670302 Inhibition of activity by 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo [ 3,4-d ] pyrimidine ( PP1 ) or depletion of c-Src is *sufficient* to abolish the 5-HT induced ( i ) PDGFR tyrosine kinase phosphorylation and MAPK activation , ( ii ) [cyclin D1] and cyclin E expression levels , and ( iii ) thymidine incorporation . Positive_regulation CCND1 SRC 12907754 1157467 Moreover , we show that both and c-Src/Fak/Erk1/2 pathways are *involved* in the up-regulation of c-myc and [cyclin d1] expression mediated by PRL . Positive_regulation CCND1 SRC 17409427 1722277 Suppression of by RNA interference in NIH3T3-ETV6-NTRK3 cells *resulted* in markedly decreased expression of [cyclin D1] and suppression of activation of Ras-Erk1/2 and PI3K-Akt . Positive_regulation CCND1 SRC 17991742 1851044 Suppression of by RNA interference in highly metastatic 4T1 mammary cancer cells , which express endogenous TrkC , *resulted* in markedly decreased expression of [cyclin D1] and suppression of activation of Ras-Erk1/2 and PI3K-Akt . Positive_regulation CCND1 SRC 18321550 1919541 Progestin induction of [CCND1] was observed in cells expressing PR-B but not PR-BDeltaSH3 or PR-A and induction in the presence of PR-B was dramatically *reduced* in the presence of inhibitors of or MAPK . Positive_regulation CCND1 SRC 18679417 1973322 inhibition *resulted* in decreased binding of beta-catenin to the promoters of G1 phase cell cycle regulators [cyclin D1] and c-Myc. C-Myc may also be regulated at the protein level by extracellular signal regulated kinase 1/2 and GSK3beta . Positive_regulation CCND1 SRC 9891045 586270 Activation of Raf , , and MEK1 *led* to induced expression of c-Myc and [cyclin D1] . Positive_regulation CCND1 SRPK2 19592491 2122867 Here we show that , a protein kinase specific for the serine/arginine ( SR ) family of splicing factors , triggers cell cycle progression in neurons and *induces* apoptosis through regulation of nuclear [cyclin D1] . Positive_regulation CCND1 SSX2 12097301 961287 is *critical* for [cyclin D1] expression in synovial sarcoma cells : a gain of function of the t ( X ; 18 ) ( p11.2 ; q11.2 ) translocation . Positive_regulation CCND1 SSX2 12097301 961289 Here we demonstrate that is *critical* for the protein level of [cyclin D1] in synovial sarcoma cells . Positive_regulation CCND1 SSX2 12097301 961293 Taken together , our study provides evidence that *stabilizes* [cyclin D1] and is critical for cyclin D1 expression in synovial sarcoma cells . Positive_regulation CCND1 SSX2 12097301 961295 *dependent* expression of [cyclin D1] may be an important mechanism in the development and progression of synovial sarcoma and also raises the possibility for targeted therapy . Positive_regulation CCND1 ST3GAL4 16892452 1783437 In addition , induction of diabetes in rats by *increases* both laminin gamma1 and [cyclin D1] expression in the renal cortex and treatment of the diabetic rats with alpha-lipoic acid ( 400 mg kg ( -1 ) body weight ) reduces the level of both proteins significantly ( p < 0.05 ) when compared to untreated diabetic rats . Positive_regulation CCND1 STAT3 12147685 985219 Activation of in fetal hepatocytes of transgenic mice expressing the STAT3-estrogen receptor fusion protein by 4-hydroxytamoxifen *resulted* in the suppression of [cyclin D1] and D2 expression . Positive_regulation CCND1 STAT3 15705584 1395679 was *required* for the RhoA induced NF-kappaB and [cyclin D1] transcription and was involved in NF-kappaB nuclear translocation . Positive_regulation CCND1 STAT3 17028185 1648932 Not only the up-regulation of p50alpha and p55alpha but also the repression of [cyclin D1] and Bcl-2 in SOCS3 ( -/- ) MEFs was *inhibited* by dominant negative . Positive_regulation CCND1 STAT3 17322172 1719828 Blockade of gp130/STAT-3 signaling via adenovirus mediated expression of dngp130 or dnSTAT-3 attenuated balloon injury induced phosphorylation and [cyclin D1] *induction* , resulting in reduced smooth muscle cell migration from media to intima and decreased neointima formation . Positive_regulation CCND1 STAT3 17344214 1726956 Our data suggest that [CYCLIN D1] may be a target gene for leptin mediated growth stimulation of breast cancer cells and molecular mechanisms *involve* activated mediated recruitment of distinct coactivator complexes . Positive_regulation CCND1 STAT3 17761947 1822741 Chromatin immunoprecipitation studies indicate that expression of LKB1 reduces the binding of STAT3 to its target promoters and suppresses *mediated* expression of [Cyclin D1] , VEGF , and Bcl-xL . Positive_regulation CCND1 STAT3 18512153 1984088 This drug significantly reduced the up-regulations of [cyclin D1] , cyclin E , c-Myc , and Bcl-2 as well as the *activation* of in SEG-1 cells . Positive_regulation CCND1 STAT3 20332458 2230779 Moreover , overexpression of constitutively active STAT3 increased cyclin D1 transcriptional activity and protein expression , whereas overexpression of a dominant negative deletion mutant ( STAT3 ( 1-588 ) ) *reduced* [cyclin D1] transcriptional activity . Positive_regulation CCND1 STAT3 20359118 2181223 Active may *promote* the transcription of target gene [Cyclin D1] , which could accelerate carcinomatous change . Positive_regulation CCND1 STAT3 21109256 2562041 Liver mass restoration was significantly retarded in the old rats , despite higher plasma IL-6 levels , rapid and prolonged *activation* of hepatic , and increased hepatocyte nuclear [cyclin D1] levels . Positive_regulation CCND1 STAT3 22216901 2559047 Down regulation of with siRNA *resulted* in a reduced expression of Bcl-2 and [cyclin D1] . Positive_regulation CCND1 STAT3 22623533 2614747 BP-1-102 mediated inhibition of aberrantly active in tumor cells *suppresses* the expression of c-Myc , [Cyclin D1] , Bcl-xL , Survivin , VEGF , and Krüppel-like factor 8 , which is identified as a Stat3 target gene that promotes Stat3 mediated breast tumor cell migration and invasion . Positive_regulation CCND1 STAT3 23300886 2712456 Pharmacological inhibition of , PI3K/Akt or MEK/ERK signaling by AG490 , Wortmannin or U0126 , respectively , *reduced* leptin induced [cyclin D1] expression and NP cell proliferation . Positive_regulation CCND1 STAT3 23329648 2758336 Expression of a Stat3S727A vector , which carries a serine-to-alanine substitution at codon 727 , shows that phosphorylation is *required* for full transcriptional activation of [cyclin D1] gene expression by progestins and for in vivo Stat3 recruitment on cyclin D1 promoter . Positive_regulation CCND1 STAT3 23800091 2885177 Consequently , the inhibitory effect of EESP on activation *resulted* in an increase in the pro-apoptotic Bax/Bcl-2 ratio , decrease in the expression of the pro-proliferative [Cyclin D1] and CDK4 , as well as down-regulation of pro-angiogenic VEGF-A and VEGFR-2 expression . Positive_regulation CCND1 STAT5A 10064602 593445 In NIH 3T3 cells , <1*6-STAT5A> and H-rasG12V individually and cooperatively *transactivated* the [cyclin D1] promoter in luciferase assays . Positive_regulation CCND1 STAT5A 14645506 1172174 Among the target genes involved in cell growth , had been shown to *activate* [cyclin D1] gene expression . Positive_regulation CCND1 STAT5A 16172916 1457394 Here , the binding of might up *regulate* [cyclin D1] in most of the samples whereas ; Positive_regulation CCND1 STAT5A 18537972 1952064 In conclusion , our studies suggest that mediated activation of HSPA8 *induces* nuclear translocation and activation of the [CCND1/CDK4 complex] leading to increased proliferation of CML cells , deciphering a new pathway implicated in CML and supporting a potential role of chaperone inhibitors in the treatment of CML . Positive_regulation CCND1 STAT5A 23504816 2772041 Overexpression studies confirmed increase in [cyclin D1] expression in *response* to and STAT5b constructs when compared to dominant negative STAT5 . Positive_regulation CCND1 STAT5A 23504816 2772043 siRNA targeting STAT5 , diminished the cyclin D1 expression , further confirming that specifically *regulated* [cyclin D1] in neuronal cells . Positive_regulation CCND1 STAT5A 24737397 2943094 Mechanistically , aberrant PRL-3 expression promoted cell cycle progression and enhanced the antiapoptotic machinery of AML cells to drug cytotoxicity through downregulation of p21 and upregulation of [Cyclin D1] and CDK2 and *activation* of and AKT . Positive_regulation CCND1 STAT5B 16155412 1455509 These data suggest that may *mediate* the transcriptional activation of [cyclin D1] after hypoxic stimulation . Positive_regulation CCND1 STAT5B 20372799 2238894 We confirmed that STAT5b , [cyclin D1] , and IGF-1R is *up-regulated* by hypoxia , and the increased binds strongly to the STAT5 binding sites contained within the distal 5'-flanking region of IGF-1 gene in breast cancer cells . Positive_regulation CCND1 STC2 23187001 2704709 Western blot analysis demonstrated that could *regulate* the expression of [cyclin D1] and activate extracellular signal regulated kinase 1/2 ( ERK1/2 ) in a dominant positive manner . Positive_regulation CCND1 SYK 19996316 2199744 Specifically , we identified the extracellular signal regulated kinase ( ERK ) signaling pathway as a mediator of signals from FcgammaR activation to cyclin D1 expression , because [cyclin D1] expression associated with FcgammaR cross linking was *attenuated* by specific inhibitors of the ERK1/2 signaling pathway , PD98059 and U0126 and the inhibitor , Piceatannol . Positive_regulation CCND1 SYT1 12097301 961288 is *critical* for [cyclin D1] expression in synovial sarcoma cells : a gain of function of the t ( X ; 18 ) ( p11.2 ; q11.2 ) translocation . Positive_regulation CCND1 SYT1 12097301 961290 Here we demonstrate that is *critical* for the protein level of [cyclin D1] in synovial sarcoma cells . Positive_regulation CCND1 SYT1 12097301 961294 Taken together , our study provides evidence that *stabilizes* [cyclin D1] and is critical for cyclin D1 expression in synovial sarcoma cells . Positive_regulation CCND1 SYT1 12097301 961296 *dependent* expression of [cyclin D1] may be an important mechanism in the development and progression of synovial sarcoma and also raises the possibility for targeted therapy . Positive_regulation CCND1 SYT1 22309289 2571266 HBx activated Akt phosphorylated its downstream target glycogen synthase kinase 3ß , leading to stabilization of ß-catenin , while phosphorylation *resulted* in enhanced promoter recruitment and expression of target genes encoding [cyclin D1] and Bcl-XL . Positive_regulation CCND1 TAT 23301033 2725844 In an allograft model , *promotes* vIL-6 induced tumorigenesis and expression of CD31 , CD34 , SMA , VEGF , b-FGF , and [cyclin D1] . Positive_regulation CCND1 TBL1X 17591692 1779286 is *required* for full expression of the ERalpha target genes [cyclin D1] , BCL-2 , and progesterone receptor but not pS2 , and its depletion significantly attenuated estrogen dependent proliferation of MCF-7 cells . Positive_regulation CCND1 TBL1X 18632669 1959965 Overexpression of and NCoR *attenuated* the transcription of beta-catenin-TCF4-specific reporter gene and of [CCND1] , an endogenous beta-catenin target gene . Positive_regulation CCND1 TBL1X 21901538 2521946 We also found that when down regulation of p65 , the expression of [cyclin D1] and Bc1-2 decreased , and the expression of *increased* in vitro and vivo . Positive_regulation CCND1 TBL1XR1 17591692 1779287 is *required* for full expression of the ERalpha target genes [cyclin D1] , BCL-2 , and progesterone receptor but not pS2 , and its depletion significantly attenuated estrogen dependent proliferation of MCF-7 cells . Positive_regulation CCND1 TBL1XR1 18632669 1959967 Overexpression of SMRT and *attenuated* the transcription of beta-catenin-TCF4-specific reporter gene and of [CCND1] , an endogenous beta-catenin target gene . Positive_regulation CCND1 TBL1XR1 21901538 2521947 We also found that when down regulation of p65 , the expression of [cyclin D1] and Bc1-2 decreased , and the expression of *increased* in vitro and vivo . Positive_regulation CCND1 TCEAL1 10974928 729347 Moreover P21 ( WAF1 ) as the main cyclin dependent kinases (CDKs) inhibitor may also inhibit the activity of the cyclins , thus overexpression of ( WAF1 ) may *result* in reduced level of [cyclin D1] . Positive_regulation CCND1 TCEAL1 12572356 1029569 Western blot analysis showed tea polyphenols and tea pigments significantly inhibited the expression of [cyclin D1] protein and *induced* higher expression of protein . Positive_regulation CCND1 TCEAL1 16711003 1564709 The expression of [cyclin D1] was decreased and *increased* significantly in ciglitazone treated group as compared with control group . Positive_regulation CCND1 TCEAL1 19396459 2271869 Our studies from pancreatic cancer cell lines indicate that targeted inhibition of hedgehog signaling by Smo signaling inhibitor KAAD-cyclopamine causes hedgehog target gene expression ( Gli1 ) suppression , *induces* expression and G1 cell population , and reduced expression of [Cyclin D1] and IGF2 . Positive_regulation CCND1 TCF12 15126340 1244809 Because [cyclin D1] is mainly *regulated* by , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Positive_regulation CCND1 TCF12 15794748 1387095 The expression of direct Wnt target genes , e.g . [cyclin D1] and MYC , is *activated* by the transcription factor , which binds to specific sequence motifs in the promoter . Positive_regulation CCND1 TCF12 17637757 1848572 Proliferation associated Brn-3b can *activate* [cyclin D1] expression in neuroblastoma and breast cancer cells . Positive_regulation CCND1 TCF12 18353896 1906248 Using the PKA inhibitor PKI or dominant negative TCF-4 mutant , we show that ATP induced [cyclin D1] promoter activation , cyclin D1 protein expression , and proliferation of VSMC are all *dependent* on PKA and activities . Positive_regulation CCND1 TCF12 19505905 2092087 In addition , we verified that hypoxia-inducible factor-1alpha , an important of nickel response , was not *required* for the [cyclin D1] or cyclin E induction . Positive_regulation CCND1 TCF12 21505178 2458337 Furthermore , a promoter analysis revealed that the activator protein-1 *regulates* EGF induced [cyclin D1] overexpression . Positive_regulation CCND1 TCF12 22005519 2526388 *dependent* transcriptional activity and [cyclin D1] promoter activity were revealed to be inhibited via suppression of transcription factor 7-like 2 (TCF7L2) expression . Positive_regulation CCND1 TCF12 24101723 2878856 Furthermore , *dependent* transcription , [Ccnd1] expression and proliferation all increase when Smad4 , 1 or 5 levels are low , whereas TCF/Lef activities decrease when Smad4 expression is high . Positive_regulation CCND1 TCF12 24801166 2937427 Expression of [cyclin-D1] , a key inducer of transition from the G1 to S phase of cell cycle , is *regulated* by <ß-catenin-TCF> complex . Positive_regulation CCND1 TCF12 24979278 2947647 Thus , full activation of [cyclin D1] promoter activity *requires* ß-catenin activation of and stabilization of specific p120 catenin isoforms to relieve the repression of KAISO . Positive_regulation CCND1 TCF12 7970707 280075 *Activation* of the E2F by [cyclin D1] is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation CCND1 TCF15 15126340 1244810 Because [cyclin D1] is mainly *regulated* by , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Positive_regulation CCND1 TCF15 15794748 1387096 The expression of direct Wnt target genes , e.g . [cyclin D1] and MYC , is *activated* by the transcription factor , which binds to specific sequence motifs in the promoter . Positive_regulation CCND1 TCF15 17637757 1848573 Proliferation associated Brn-3b can *activate* [cyclin D1] expression in neuroblastoma and breast cancer cells . Positive_regulation CCND1 TCF15 18353896 1906249 Using the PKA inhibitor PKI or dominant negative TCF-4 mutant , we show that ATP induced [cyclin D1] promoter activation , cyclin D1 protein expression , and proliferation of VSMC are all *dependent* on PKA and activities . Positive_regulation CCND1 TCF15 19505905 2092088 In addition , we verified that hypoxia-inducible factor-1alpha , an important of nickel response , was not *required* for the [cyclin D1] or cyclin E induction . Positive_regulation CCND1 TCF15 21505178 2458338 Furthermore , a promoter analysis revealed that the activator protein-1 *regulates* EGF induced [cyclin D1] overexpression . Positive_regulation CCND1 TCF15 22005519 2526389 *dependent* transcriptional activity and [cyclin D1] promoter activity were revealed to be inhibited via suppression of transcription factor 7-like 2 (TCF7L2) expression . Positive_regulation CCND1 TCF15 24101723 2878857 Furthermore , *dependent* transcription , [Ccnd1] expression and proliferation all increase when Smad4 , 1 or 5 levels are low , whereas TCF/Lef activities decrease when Smad4 expression is high . Positive_regulation CCND1 TCF15 24801166 2937428 Expression of [cyclin-D1] , a key inducer of transition from the G1 to S phase of cell cycle , is *regulated* by <ß-catenin-TCF> complex . Positive_regulation CCND1 TCF15 24979278 2947648 Thus , full activation of [cyclin D1] promoter activity *requires* ß-catenin activation of and stabilization of specific p120 catenin isoforms to relieve the repression of KAISO . Positive_regulation CCND1 TCF15 7970707 280076 *Activation* of the E2F by [cyclin D1] is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation CCND1 TCF19 15126340 1244811 Because [cyclin D1] is mainly *regulated* by , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Positive_regulation CCND1 TCF19 15794748 1387097 The expression of direct Wnt target genes , e.g . [cyclin D1] and MYC , is *activated* by the transcription factor , which binds to specific sequence motifs in the promoter . Positive_regulation CCND1 TCF19 17637757 1848574 Proliferation associated Brn-3b can *activate* [cyclin D1] expression in neuroblastoma and breast cancer cells . Positive_regulation CCND1 TCF19 18353896 1906250 Using the PKA inhibitor PKI or dominant negative TCF-4 mutant , we show that ATP induced [cyclin D1] promoter activation , cyclin D1 protein expression , and proliferation of VSMC are all *dependent* on PKA and activities . Positive_regulation CCND1 TCF19 19505905 2092089 In addition , we verified that hypoxia-inducible factor-1alpha , an important of nickel response , was not *required* for the [cyclin D1] or cyclin E induction . Positive_regulation CCND1 TCF19 21505178 2458339 Furthermore , a promoter analysis revealed that the activator protein-1 *regulates* EGF induced [cyclin D1] overexpression . Positive_regulation CCND1 TCF19 22005519 2526390 *dependent* transcriptional activity and [cyclin D1] promoter activity were revealed to be inhibited via suppression of transcription factor 7-like 2 (TCF7L2) expression . Positive_regulation CCND1 TCF19 24101723 2878858 Furthermore , *dependent* transcription , [Ccnd1] expression and proliferation all increase when Smad4 , 1 or 5 levels are low , whereas TCF/Lef activities decrease when Smad4 expression is high . Positive_regulation CCND1 TCF19 24801166 2937429 Expression of [cyclin-D1] , a key inducer of transition from the G1 to S phase of cell cycle , is *regulated* by <ß-catenin-TCF> complex . Positive_regulation CCND1 TCF19 24979278 2947649 Thus , full activation of [cyclin D1] promoter activity *requires* ß-catenin activation of and stabilization of specific p120 catenin isoforms to relieve the repression of KAISO . Positive_regulation CCND1 TCF19 7970707 280077 *Activation* of the E2F by [cyclin D1] is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation CCND1 TCF20 15126340 1244812 Because [cyclin D1] is mainly *regulated* by , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Positive_regulation CCND1 TCF20 15794748 1387098 The expression of direct Wnt target genes , e.g . [cyclin D1] and MYC , is *activated* by the transcription factor , which binds to specific sequence motifs in the promoter . Positive_regulation CCND1 TCF20 17637757 1848575 Proliferation associated Brn-3b can *activate* [cyclin D1] expression in neuroblastoma and breast cancer cells . Positive_regulation CCND1 TCF20 18353896 1906251 Using the PKA inhibitor PKI or dominant negative TCF-4 mutant , we show that ATP induced [cyclin D1] promoter activation , cyclin D1 protein expression , and proliferation of VSMC are all *dependent* on PKA and activities . Positive_regulation CCND1 TCF20 19505905 2092090 In addition , we verified that hypoxia-inducible factor-1alpha , an important of nickel response , was not *required* for the [cyclin D1] or cyclin E induction . Positive_regulation CCND1 TCF20 21505178 2458340 Furthermore , a promoter analysis revealed that the activator protein-1 *regulates* EGF induced [cyclin D1] overexpression . Positive_regulation CCND1 TCF20 22005519 2526391 *dependent* transcriptional activity and [cyclin D1] promoter activity were revealed to be inhibited via suppression of transcription factor 7-like 2 (TCF7L2) expression . Positive_regulation CCND1 TCF20 24101723 2878859 Furthermore , *dependent* transcription , [Ccnd1] expression and proliferation all increase when Smad4 , 1 or 5 levels are low , whereas TCF/Lef activities decrease when Smad4 expression is high . Positive_regulation CCND1 TCF20 24801166 2937430 Expression of [cyclin-D1] , a key inducer of transition from the G1 to S phase of cell cycle , is *regulated* by <ß-catenin-TCF> complex . Positive_regulation CCND1 TCF20 24979278 2947650 Thus , full activation of [cyclin D1] promoter activity *requires* ß-catenin activation of and stabilization of specific p120 catenin isoforms to relieve the repression of KAISO . Positive_regulation CCND1 TCF20 7970707 280078 *Activation* of the E2F by [cyclin D1] is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation CCND1 TCF21 15126340 1244813 Because [cyclin D1] is mainly *regulated* by , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Positive_regulation CCND1 TCF21 15794748 1387099 The expression of direct Wnt target genes , e.g . [cyclin D1] and MYC , is *activated* by the transcription factor , which binds to specific sequence motifs in the promoter . Positive_regulation CCND1 TCF21 17637757 1848576 Proliferation associated Brn-3b can *activate* [cyclin D1] expression in neuroblastoma and breast cancer cells . Positive_regulation CCND1 TCF21 18353896 1906252 Using the PKA inhibitor PKI or dominant negative TCF-4 mutant , we show that ATP induced [cyclin D1] promoter activation , cyclin D1 protein expression , and proliferation of VSMC are all *dependent* on PKA and activities . Positive_regulation CCND1 TCF21 19505905 2092091 In addition , we verified that hypoxia-inducible factor-1alpha , an important of nickel response , was not *required* for the [cyclin D1] or cyclin E induction . Positive_regulation CCND1 TCF21 21505178 2458341 Furthermore , a promoter analysis revealed that the activator protein-1 *regulates* EGF induced [cyclin D1] overexpression . Positive_regulation CCND1 TCF21 22005519 2526392 *dependent* transcriptional activity and [cyclin D1] promoter activity were revealed to be inhibited via suppression of transcription factor 7-like 2 (TCF7L2) expression . Positive_regulation CCND1 TCF21 24101723 2878860 Furthermore , *dependent* transcription , [Ccnd1] expression and proliferation all increase when Smad4 , 1 or 5 levels are low , whereas TCF/Lef activities decrease when Smad4 expression is high . Positive_regulation CCND1 TCF21 24801166 2937431 Expression of [cyclin-D1] , a key inducer of transition from the G1 to S phase of cell cycle , is *regulated* by <ß-catenin-TCF> complex . Positive_regulation CCND1 TCF21 24979278 2947651 Thus , full activation of [cyclin D1] promoter activity *requires* ß-catenin activation of and stabilization of specific p120 catenin isoforms to relieve the repression of KAISO . Positive_regulation CCND1 TCF21 7970707 280079 *Activation* of the E2F by [cyclin D1] is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation CCND1 TCF23 15126340 1244817 Because [cyclin D1] is mainly *regulated* by , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Positive_regulation CCND1 TCF23 15794748 1387103 The expression of direct Wnt target genes , e.g . [cyclin D1] and MYC , is *activated* by the transcription factor , which binds to specific sequence motifs in the promoter . Positive_regulation CCND1 TCF23 17637757 1848580 Proliferation associated Brn-3b can *activate* [cyclin D1] expression in neuroblastoma and breast cancer cells . Positive_regulation CCND1 TCF23 18353896 1906256 Using the PKA inhibitor PKI or dominant negative TCF-4 mutant , we show that ATP induced [cyclin D1] promoter activation , cyclin D1 protein expression , and proliferation of VSMC are all *dependent* on PKA and activities . Positive_regulation CCND1 TCF23 19505905 2092095 In addition , we verified that hypoxia-inducible factor-1alpha , an important of nickel response , was not *required* for the [cyclin D1] or cyclin E induction . Positive_regulation CCND1 TCF23 21505178 2458345 Furthermore , a promoter analysis revealed that the activator protein-1 *regulates* EGF induced [cyclin D1] overexpression . Positive_regulation CCND1 TCF23 22005519 2526396 *dependent* transcriptional activity and [cyclin D1] promoter activity were revealed to be inhibited via suppression of transcription factor 7-like 2 (TCF7L2) expression . Positive_regulation CCND1 TCF23 24101723 2878864 Furthermore , *dependent* transcription , [Ccnd1] expression and proliferation all increase when Smad4 , 1 or 5 levels are low , whereas TCF/Lef activities decrease when Smad4 expression is high . Positive_regulation CCND1 TCF23 24801166 2937435 Expression of [cyclin-D1] , a key inducer of transition from the G1 to S phase of cell cycle , is *regulated* by <ß-catenin-TCF> complex . Positive_regulation CCND1 TCF23 24979278 2947655 Thus , full activation of [cyclin D1] promoter activity *requires* ß-catenin activation of and stabilization of specific p120 catenin isoforms to relieve the repression of KAISO . Positive_regulation CCND1 TCF23 7970707 280084 *Activation* of the E2F by [cyclin D1] is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation CCND1 TCF24 15126340 1244820 Because [cyclin D1] is mainly *regulated* by , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Positive_regulation CCND1 TCF24 15794748 1387105 The expression of direct Wnt target genes , e.g . [cyclin D1] and MYC , is *activated* by the transcription factor , which binds to specific sequence motifs in the promoter . Positive_regulation CCND1 TCF24 17637757 1848582 Proliferation associated Brn-3b can *activate* [cyclin D1] expression in neuroblastoma and breast cancer cells . Positive_regulation CCND1 TCF24 18353896 1906258 Using the PKA inhibitor PKI or dominant negative TCF-4 mutant , we show that ATP induced [cyclin D1] promoter activation , cyclin D1 protein expression , and proliferation of VSMC are all *dependent* on PKA and activities . Positive_regulation CCND1 TCF24 19505905 2092097 In addition , we verified that hypoxia-inducible factor-1alpha , an important of nickel response , was not *required* for the [cyclin D1] or cyclin E induction . Positive_regulation CCND1 TCF24 21505178 2458347 Furthermore , a promoter analysis revealed that the activator protein-1 *regulates* EGF induced [cyclin D1] overexpression . Positive_regulation CCND1 TCF24 22005519 2526398 *dependent* transcriptional activity and [cyclin D1] promoter activity were revealed to be inhibited via suppression of transcription factor 7-like 2 (TCF7L2) expression . Positive_regulation CCND1 TCF24 24101723 2878866 Furthermore , *dependent* transcription , [Ccnd1] expression and proliferation all increase when Smad4 , 1 or 5 levels are low , whereas TCF/Lef activities decrease when Smad4 expression is high . Positive_regulation CCND1 TCF24 24801166 2937437 Expression of [cyclin-D1] , a key inducer of transition from the G1 to S phase of cell cycle , is *regulated* by <ß-catenin-TCF> complex . Positive_regulation CCND1 TCF24 24979278 2947658 Thus , full activation of [cyclin D1] promoter activity *requires* ß-catenin activation of and stabilization of specific p120 catenin isoforms to relieve the repression of KAISO . Positive_regulation CCND1 TCF24 7970707 280086 *Activation* of the E2F by [cyclin D1] is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation CCND1 TCF25 15126340 1244819 Because [cyclin D1] is mainly *regulated* by , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Positive_regulation CCND1 TCF25 15794748 1387104 The expression of direct Wnt target genes , e.g . [cyclin D1] and MYC , is *activated* by the transcription factor , which binds to specific sequence motifs in the promoter . Positive_regulation CCND1 TCF25 17637757 1848581 Proliferation associated Brn-3b can *activate* [cyclin D1] expression in neuroblastoma and breast cancer cells . Positive_regulation CCND1 TCF25 18353896 1906257 Using the PKA inhibitor PKI or dominant negative TCF-4 mutant , we show that ATP induced [cyclin D1] promoter activation , cyclin D1 protein expression , and proliferation of VSMC are all *dependent* on PKA and activities . Positive_regulation CCND1 TCF25 19505905 2092096 In addition , we verified that hypoxia-inducible factor-1alpha , an important of nickel response , was not *required* for the [cyclin D1] or cyclin E induction . Positive_regulation CCND1 TCF25 21505178 2458346 Furthermore , a promoter analysis revealed that the activator protein-1 *regulates* EGF induced [cyclin D1] overexpression . Positive_regulation CCND1 TCF25 22005519 2526397 *dependent* transcriptional activity and [cyclin D1] promoter activity were revealed to be inhibited via suppression of transcription factor 7-like 2 (TCF7L2) expression . Positive_regulation CCND1 TCF25 24101723 2878865 Furthermore , *dependent* transcription , [Ccnd1] expression and proliferation all increase when Smad4 , 1 or 5 levels are low , whereas TCF/Lef activities decrease when Smad4 expression is high . Positive_regulation CCND1 TCF25 24801166 2937436 Expression of [cyclin-D1] , a key inducer of transition from the G1 to S phase of cell cycle , is *regulated* by <ß-catenin-TCF> complex . Positive_regulation CCND1 TCF25 24979278 2947657 Thus , full activation of [cyclin D1] promoter activity *requires* ß-catenin activation of and stabilization of specific p120 catenin isoforms to relieve the repression of KAISO . Positive_regulation CCND1 TCF25 7970707 280085 *Activation* of the E2F by [cyclin D1] is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation CCND1 TCF3 15126340 1244814 Because [cyclin D1] is mainly *regulated* by , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Positive_regulation CCND1 TCF3 15794748 1387100 The expression of direct Wnt target genes , e.g . [cyclin D1] and MYC , is *activated* by the transcription factor , which binds to specific sequence motifs in the promoter . Positive_regulation CCND1 TCF3 17637757 1848577 Proliferation associated Brn-3b can *activate* [cyclin D1] expression in neuroblastoma and breast cancer cells . Positive_regulation CCND1 TCF3 18353896 1906253 Using the PKA inhibitor PKI or dominant negative TCF-4 mutant , we show that ATP induced [cyclin D1] promoter activation , cyclin D1 protein expression , and proliferation of VSMC are all *dependent* on PKA and activities . Positive_regulation CCND1 TCF3 19505905 2092092 In addition , we verified that hypoxia-inducible factor-1alpha , an important of nickel response , was not *required* for the [cyclin D1] or cyclin E induction . Positive_regulation CCND1 TCF3 21505178 2458342 Furthermore , a promoter analysis revealed that the activator protein-1 *regulates* EGF induced [cyclin D1] overexpression . Positive_regulation CCND1 TCF3 22005519 2526393 *dependent* transcriptional activity and [cyclin D1] promoter activity were revealed to be inhibited via suppression of transcription factor 7-like 2 (TCF7L2) expression . Positive_regulation CCND1 TCF3 24101723 2878861 Furthermore , *dependent* transcription , [Ccnd1] expression and proliferation all increase when Smad4 , 1 or 5 levels are low , whereas TCF/Lef activities decrease when Smad4 expression is high . Positive_regulation CCND1 TCF3 24801166 2937432 Expression of [cyclin-D1] , a key inducer of transition from the G1 to S phase of cell cycle , is *regulated* by <ß-catenin-TCF> complex . Positive_regulation CCND1 TCF3 24979278 2947652 Thus , full activation of [cyclin D1] promoter activity *requires* ß-catenin activation of and stabilization of specific p120 catenin isoforms to relieve the repression of KAISO . Positive_regulation CCND1 TCF3 7970707 280080 *Activation* of the E2F by [cyclin D1] is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation CCND1 TCF4 15126340 1244815 Because [cyclin D1] is mainly *regulated* by , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Positive_regulation CCND1 TCF4 15794748 1387101 The expression of direct Wnt target genes , e.g . [cyclin D1] and MYC , is *activated* by the transcription factor , which binds to specific sequence motifs in the promoter . Positive_regulation CCND1 TCF4 17637757 1848578 Proliferation associated Brn-3b can *activate* [cyclin D1] expression in neuroblastoma and breast cancer cells . Positive_regulation CCND1 TCF4 18353896 1906254 Using the PKA inhibitor PKI or dominant negative TCF-4 mutant , we show that ATP induced [cyclin D1] promoter activation , cyclin D1 protein expression , and proliferation of VSMC are all *dependent* on PKA and activities . Positive_regulation CCND1 TCF4 19505905 2092093 In addition , we verified that hypoxia-inducible factor-1alpha , an important of nickel response , was not *required* for the [cyclin D1] or cyclin E induction . Positive_regulation CCND1 TCF4 21505178 2458343 Furthermore , a promoter analysis revealed that the activator protein-1 *regulates* EGF induced [cyclin D1] overexpression . Positive_regulation CCND1 TCF4 22005519 2526394 *dependent* transcriptional activity and [cyclin D1] promoter activity were revealed to be inhibited via suppression of transcription factor 7-like 2 (TCF7L2) expression . Positive_regulation CCND1 TCF4 24101723 2878862 Furthermore , *dependent* transcription , [Ccnd1] expression and proliferation all increase when Smad4 , 1 or 5 levels are low , whereas TCF/Lef activities decrease when Smad4 expression is high . Positive_regulation CCND1 TCF4 24801166 2937433 Expression of [cyclin-D1] , a key inducer of transition from the G1 to S phase of cell cycle , is *regulated* by <ß-catenin-TCF> complex . Positive_regulation CCND1 TCF4 24979278 2947653 Thus , full activation of [cyclin D1] promoter activity *requires* ß-catenin activation of and stabilization of specific p120 catenin isoforms to relieve the repression of KAISO . Positive_regulation CCND1 TCF4 7970707 280081 *Activation* of the E2F by [cyclin D1] is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation CCND1 TCF7 15126340 1244816 Because [cyclin D1] is mainly *regulated* by , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Positive_regulation CCND1 TCF7 15794748 1387102 The expression of direct Wnt target genes , e.g . [cyclin D1] and MYC , is *activated* by the transcription factor , which binds to specific sequence motifs in the promoter . Positive_regulation CCND1 TCF7 17637757 1848579 Proliferation associated Brn-3b can *activate* [cyclin D1] expression in neuroblastoma and breast cancer cells . Positive_regulation CCND1 TCF7 18353896 1906255 Using the PKA inhibitor PKI or dominant negative TCF-4 mutant , we show that ATP induced [cyclin D1] promoter activation , cyclin D1 protein expression , and proliferation of VSMC are all *dependent* on PKA and activities . Positive_regulation CCND1 TCF7 19505905 2092094 In addition , we verified that hypoxia-inducible factor-1alpha , an important of nickel response , was not *required* for the [cyclin D1] or cyclin E induction . Positive_regulation CCND1 TCF7 21505178 2458344 Furthermore , a promoter analysis revealed that the activator protein-1 *regulates* EGF induced [cyclin D1] overexpression . Positive_regulation CCND1 TCF7 22005519 2526395 *dependent* transcriptional activity and [cyclin D1] promoter activity were revealed to be inhibited via suppression of transcription factor 7-like 2 (TCF7L2) expression . Positive_regulation CCND1 TCF7 24101723 2878863 Furthermore , *dependent* transcription , [Ccnd1] expression and proliferation all increase when Smad4 , 1 or 5 levels are low , whereas TCF/Lef activities decrease when Smad4 expression is high . Positive_regulation CCND1 TCF7 24801166 2937434 Expression of [cyclin-D1] , a key inducer of transition from the G1 to S phase of cell cycle , is *regulated* by <ß-catenin-TCF> complex . Positive_regulation CCND1 TCF7 24979278 2947654 Thus , full activation of [cyclin D1] promoter activity *requires* ß-catenin activation of and stabilization of specific p120 catenin isoforms to relieve the repression of KAISO . Positive_regulation CCND1 TCF7 7970707 280082 *Activation* of the E2F by [cyclin D1] is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation CCND1 TCF7L2 10679386 668916 For instance the discovery that [cyclin D1] is *regulated* by allows us to tie the APC pathway to the RB pathway and cell cycle control . Positive_regulation CCND1 TCF7L2 22005519 2526411 Moreover , RNAi mediated depletion of endogenous *resulted* in reduced [cyclin D1] promoter activity and protein expression , and the overexpression of TCF7L2 overrode the inhibition of the TCF dependent transcriptional activity and cyclin D1 promoter activity induced by DIF-1 . Positive_regulation CCND1 TCF7L2 22318732 2571530 These findings indicate that the MUC1-C oncoprotein contributes to activation and thereby *promotes* [cyclin D1] expression in breast cancer cells . Positive_regulation CCND1 TDP2 21478903 2469815 Consistently , the protein and mRNA levels of MYC and [cyclin D1] , which are targets of the mitogen activated protein kinase/extracellular signal regulated kinase ( MAPK-ERK ) pathway , are significantly *increased* by overexpression . Positive_regulation CCND1 TERT 9207452 440856 There was a correlation between activity , cell cycle status by BrdU incorporation , and *induction* of phosphorylated retinoblastoma protein , CDC2 , CDK2 , [cyclin D1] , and cyclin A , but not cyclin E and B1 after 72 hours with multiple ( but not single ) cytokines . Positive_regulation CCND1 TEX11 22383461 2576964 Overexpression of in mouse germ-cell derived GC-1 and GC-2 cells *suppressed* the cell proliferation and the expression of cFos , [Ccnd1] , and Ccnb1 that were stimulated by 17ß-estradiol or diarylpropionitrile and elevated the expression level of the proapoptotic Bax gene . Positive_regulation CCND1 TGFA 11751523 889950 Treatment with EGCG inhibited phosphorylation of the EGFR , signal transducer and activator of transcription3 ( Stat3 ) , and extracellular regulated kinase (ERK) proteins and also inhibited basal and *stimulated* c-fos and [cyclin D1] promoter activity . Positive_regulation CCND1 TGFA 9407106 470871 *enhances* [cyclin D1] transcription through the binding of early growth response protein to a cis-regulatory element in the cyclin D1 promoter . Positive_regulation CCND1 TGFB1 10542199 563573 *induced* a transient increase in the expression of Cdc2 , cyclin A , cyclin B , and [cyclin D1] at an early phase of apoptosis . Positive_regulation CCND1 TGFB1 16690606 1584224 *stimulates* [cyclin D1] expression through activation of beta-catenin signaling in chondrocytes . Positive_regulation CCND1 TGFB2 16690606 1584225 *stimulates* [cyclin D1] expression through activation of beta-catenin signaling in chondrocytes . Positive_regulation CCND1 TGFB3 16323168 1490903 We also detected increased [cyclin D1] expression ( a marker for cell proliferation ) in the *presence* of , which suggests that TGF-beta3 promoted cell proliferation . Positive_regulation CCND1 TGFB3 16690606 1584226 *stimulates* [cyclin D1] expression through activation of beta-catenin signaling in chondrocytes . Positive_regulation CCND1 THPO 14645506 1172175 We now show that *dependent* activation of the [cyclin D1] promoter depends on the integrity of a new bipartite proximal element that specifically binds STAT5A and -B transcription factors . Positive_regulation CCND1 TIMP1 16407831 1561056 We also show that *mediated* differential regulation of [cyclin D(1)] and p27 ( KIP1 ) is independent of cell adhesion signaling . Positive_regulation CCND1 TIPRL 25135222 2957395 nuclear translocation negatively *regulates* EGF dependent [cyclin D1] transcription in human lung adenocarcinoma . Positive_regulation CCND1 TIPRL 25135222 2957398 Chromatin immunoprecipitation assays revealed that negatively *regulated* EGF dependent transcriptional activation of [CCND1] through a HDAC1 dependent mechanism . Positive_regulation CCND1 TJP2 17881732 1823721 Here , we have studied the *role* of , a TJ peripheral protein , in the regulation of [cyclin D1] transcription . Positive_regulation CCND1 TJP2 17881732 1823724 To understand how ZO-2 represses cyclin D1 promoter activity , we used deletion analyses and found that negatively *regulates* [cyclin D1] transcription via an E box and that it diminishes cell proliferation . Positive_regulation CCND1 TLK1 21306487 2410482 Downregulation of levels *results* in undue nuclear accumulation of [cyclin D1] and increased Cdk4 dependent phosphorylation of pRB under quiescence conditions . Positive_regulation CCND1 TLK1 21306487 2410486 In turn , overexpression of *prevents* proper [cyclin D1] accumulation in the nucleus of proliferating cells in an interaction dependent manner , inhibits Cdk4 dependent phosphorylation of pRB and hinders cell cycle progression to S phase . Positive_regulation CCND1 TLK2 21306487 2410483 Downregulation of levels *results* in undue nuclear accumulation of [cyclin D1] and increased Cdk4 dependent phosphorylation of pRB under quiescence conditions . Positive_regulation CCND1 TLK2 21306487 2410487 In turn , overexpression of *prevents* proper [cyclin D1] accumulation in the nucleus of proliferating cells in an interaction dependent manner , inhibits Cdk4 dependent phosphorylation of pRB and hinders cell cycle progression to S phase . Positive_regulation CCND1 TMED7 11123288 768681 VCAM-1 ligation activated extracellular signal regulated kinase 2 and *resulted* in increased expression of [cyclin D1] , yet there was neither ( kip1 ) degradation nor an increase in smooth muscle cell DNA synthesis . Positive_regulation CCND1 TMED7 14566962 1155087 This was associated with increased protein content of [cyclin D1] and Cdk4 and decreased *activation* of p21 ( cip1 ) and ( kip1 ) . Positive_regulation CCND1 TMED7 15154924 1250403 Lower levels of [cyclin D1] were detected in the JE of p21/p27 knockout mice , suggesting that p21 and *regulate* stability of cyclin D1 in oral epithelium . Positive_regulation CCND1 TMED7 15161838 1252949 ( kip1 ) AS oligo transfection *increased* [cyclin-D1] , -E , -A , and -B1 protein levels , and all cyclins were localized to the nucleus . Positive_regulation CCND1 TMED7 16916940 1646405 By contrast , TSH repressed or did not *induce* [cyclin D1] and p21 , and it rather up-regulated . Positive_regulation CCND1 TMED7 17047061 1635858 [Cyclin D1] induction of cellular migration *requires* ( KIP1 ) . Positive_regulation CCND1 TMED7 17047061 1635860 [Cyclin D1] regulated p27 ( KIP1 ) abundance at the posttranslational level , inhibiting the Skp2 promoter , Skp2 abundance , and *induced* ( KIP1 ) phosphorylation at Ser ( 10 ) . Positive_regulation CCND1 TMED7 17089025 1644255 ( KIP1 ) phosphorylation and [cyclin D1] *induction* were inhibited by PD98059 . Positive_regulation CCND1 TMED7 24023847 2842018 Knockdown of Livin induced the apoptosis by up-regulating of caspase-3 , -7 and PARP activities and the cell cycle arrest by decreasing [cyclin D1] , cyclin D3 , cyclin dependent kinase 4 and 6 , and by *inducing* expression . Positive_regulation CCND1 TMED7 24639504 2930442 SMAD7 promotes beta-cell proliferation by increasing [CyclinD1] and CyclinD2 , and by *inducing* nuclear exclusion of . Positive_regulation CCND1 TNF 12730884 1086816 Leptin replacement corrected these defects in ob/ob mice by restoring and IL-6 release and *inducing* [cyclin D1] . Positive_regulation CCND1 TNF 14630924 1201132 Flavopiridol also inhibited the expression of the *induced* NF-kappaB regulated gene products [cyclin D1] , cyclooxygenase-2 , and matrix metalloproteinase-9 . Positive_regulation CCND1 TNF 17008396 1674087 Using MEC from p50 null mice , we found that p50 was not required for *induced* growth nor for up-regulation of [cyclin D1] . Positive_regulation CCND1 TNF 17008396 1674106 These data suggest that in wild-type MEC , *stimulates* the interaction of bcl3 with p50 and p52 , and the binding of p52 , as well as RelB , to [cyclin D1] promoter kappaB sites , and as a consequence , stimulates the growth of MEC . Positive_regulation CCND1 TNF 18600306 1966162 *led* to the upregulated expression of the proliferation associated gene [cyclin D1] . Positive_regulation CCND1 TNF 18957422 2001148 Activation of Plk1 inhibited *induced* expression of [cyclin D1] . Positive_regulation CCND1 TNF 18957422 2001149 Moreover , we identify Plk1 as a gammaBD kinase , which negatively regulates *induced* IKK activation and [cyclin D1] expression , thereby affecting cell cycle regulation . Positive_regulation CCND1 TNF 18957422 2001154 Untimely *activation* of [cyclin D1] by can provide a potential mechanism for an involvement of TNFalpha in inflammation induced cancer . Positive_regulation CCND1 TNF 21221075 2392182 Neutralization of TNFR2 on podocytes with blocking antibodies abrogated NF-?B activation and the *induction* of [cyclin D1] by , and identified TNFR2 as the primary receptor that induced I?Ba degradation , the initiating event in NF-?B activation . Positive_regulation CCND1 TNF 21811927 2462726 Furthermore , treatment with OD 78 decreased *induced* levels of cyclin E , [cyclin D1] , CDK2 , proliferating cell nuclear antigen , and phosphorylated retinoblastoma protein , but not the CDK4 expression level . Positive_regulation CCND1 TNF 21820422 2490438 Triptolide also abrogated *induced* expression of cell survival proteins ( XIAP , Bcl-x ( L ) , Bcl-2 , survivin , cIAP-1 and cIAP-2 ) , cell proliferative proteins ( [cyclin D1] , c-myc and cyclooxygenase-2 ) , and metastasis proteins ( ICAM-1 and MMP-9 ) . Positive_regulation CCND1 TNP1 15276080 1276792 We have found that did not only *induce* p53 and p21 ( Cip1 ) but also [cyclin D1] in the basic fibroblast growth factors (bFGF) treated endothelial cells . Positive_regulation CCND1 TNP1 15276080 1276796 The mediated *increase* of [cyclin D1] protein was due to the enhanced expression of mRNA . Positive_regulation CCND1 TNP2 15276080 1276793 We have found that did not only *induce* p53 and p21 ( Cip1 ) but also [cyclin D1] in the basic fibroblast growth factors (bFGF) treated endothelial cells . Positive_regulation CCND1 TNP2 15276080 1276797 The mediated *increase* of [cyclin D1] protein was due to the enhanced expression of mRNA . Positive_regulation CCND1 TP53 11798189 902329 *inhibits* adriamycin induced down-regulation of [cyclin D1] expression in human cancer cells . Positive_regulation CCND1 TP53 11798189 902331 Our results suggest that ectopic wild-type gene transfer *results* in increased [cyclin D1] expression and , consequently , sensitizes human colorectal cancer cells to chemotherapeutic agents . Positive_regulation CCND1 TP53 12480939 1078961 Bcl-2 controls caspase activation following a *dependent* [cyclin D1-induced] death signal . Positive_regulation CCND1 TP53 17935714 1819774 Therefore this p53 null cell line indicates that is an indispensable component of cellular signaling system which is regulated by caveolin-1 expression , involving Akt activation and *increase* in [cyclin D1] , thereby promoting proliferation of breast cancer cells . Positive_regulation CCND1 TP53 20062013 2212065 expression *results* in increased p21 expression , a negative cell-cycle regulatory protein and an inhibitor of [cyclin D1] . Positive_regulation CCND1 TP53 22445757 2582884 In addition , inhibition of activity *reduced* the expression levels of [cyclin D1] and Nanog . Positive_regulation CCND1 TP53 7671232 322620 , through p21 ( WAF1/CIP1 ) , *induces* [cyclin D1] synthesis . Positive_regulation CCND1 TP53 7671232 322623 We show here that accumulation of the wild-type protein in either human or murine cells markedly *increases* expression of [cyclin D1] . Positive_regulation CCND1 TP53 7784093 309887 The *role* of in coordinated regulation of [cyclin D1] and p21 gene expression by the adenovirus E1A and E1B oncogenes . Positive_regulation CCND1 TP53 7784093 309892 Since E1B was shown to target p53 , we investigated the *role* of for expression of the [cyclin D1] gene . Positive_regulation CCND1 TPO 10681535 669398 We found that stimulation or Ha-Ras ( G12V ) expression *led* to up-regulation of [cyclin D1] , cyclin D2 , and cyclin D3 expression . Positive_regulation CCND1 TWIST1 18442194 1900493 However , suppression of ( TwistAS-MKN45 ) inhibited MKN45 cell invasion and the expression of [cyclin D1] was *reduced* . Positive_regulation CCND1 URGCP 20714998 2306650 Over-expression of *up-regulated* [cyclin D1] mRNA expression , whereas RNA interference mediated URG4 silencing diminished cyclin D1 mRNA expression in HepG2 cells . Positive_regulation CCND1 VCAM1 11123288 768680 ligation activated extracellular signal regulated kinase 2 and *resulted* in increased expression of [cyclin D1] , yet there was neither p27 ( kip1 ) degradation nor an increase in smooth muscle cell DNA synthesis . Positive_regulation CCND1 VEGFA 12909331 1121964 Western blot analysis shows that delphinidin reverses the vascular endothelial growth factor induced decrease in expression of cyclin dependent kinase inhibitor p27 ( kip1 ) and the *induced* increase of [cyclin D1] and cyclin A , both being necessary to achieve the G ( 1 ) -to-S transition . Positive_regulation CCND1 VEGFA 14656993 1202003 Conversely , sustained activation of p38 MAPK by the p38 MAPK activating kinases MKK3 and MKK6 or transfection with Sema-3A inhibited *induced* [cyclin D1] up-regulation and MM cell proliferation . Positive_regulation CCND1 VEGFA 15351862 1292677 6 ) EHNA and RP73401 together blocked the *induced* increase in [cyclin D1] and decrease in p21 waf1/cip1 expressions ; Positive_regulation CCND1 VEGFA 15672866 1350778 Inostamycin inhibited activation of mitogen activated kinases ( ERK and p38 ) and elevation of [cyclin D1] *induced* by . Positive_regulation CCND1 VEGFA 15850596 1399252 The crude extract and fractionated fractions , except for Fra-2 , of A. cinnamomea polysaccharides significantly decreased VEGFR2 phosphorylation on tyrosine 1054/1059 , [cyclin D1] promotor activity , and protein expression *induced* by . Positive_regulation CCND1 VEGFA 16899623 1601252 In cultures of human umbilical vein endothelial cells ( HUVEC ) , *augmented* [cyclin D1] expression and cell growth . Positive_regulation CCND1 VEGFA 9756915 535823 *stimulated* both [cyclin D1] synthesis and Cdk4 kinase activity , inhibited by PD 98059 and dominant negative JNK-1 . Positive_regulation CCND1 VIP 19189304 2061262 *increased* cell proliferation and [cyclin D1] expression whereas it decreased cell adhesion and E-cadherin expression in LNCaP and PC3 cells . Positive_regulation CCND1 VRK1 18713830 1955562 phosphorylates CREB and *mediates* [CCND1] expression . Positive_regulation CCND1 VWF 15094932 1238349 It is thus concluded that using [Bcl 1] and Xba 1 linkage analysis , carrier status can be definitely ascertained in 50 % females and this level of information can be *increased* to 61.5 % by measuring antigen levels in them . Positive_regulation CCND1 WHSC1 22028615 2499196 interacts with some proteins related to the WNT pathway including ß-catenin and transcriptionally *regulates* [CCND1] , the target gene of the ß-catenin/Tcf-4 complex , through histone H3 at lysine 36 trimethylation . Positive_regulation CCND1 WNT1 10748202 690946 However , in the absence of serum derived growth factors , was not *sufficient* to drive [cyclin D1] accumulation or S-phase entry . Positive_regulation CCND1 WNT1 12612606 1063442 and Wnt5a *induce* [cyclin D1] expression through ErbB1 transactivation in HC11 mammary epithelial cells . Positive_regulation CCND1 WNT1 12805222 1101590 Ectopic expression of Dab2 in NIH-3T3 mouse fibroblasts attenuates canonical mediated signaling , including accumulation of beta-catenin , activation of beta-catenin/T-cell-specific factor/lymphoid enhancer binding factor 1-dependent reporter constructs , and endogenous [cyclin D1] *induction* . Positive_regulation CCND1 WNT1 15271658 1333175 Expression of the dominant interfering LRP6DeltaC transgene was sufficient to abolish the *induced* survival as well as [cyclin D1] activity and cell cycle progression . Positive_regulation CCND1 WNT1 17988238 1866766 Heterologous expression of *enhanced* [ 3H ] thymidine incorporation and expression of [cyclin D1] and cylin E in PC12 cells . Positive_regulation CCND1 WNT1 20735988 2324323 Our results show that activation of signaling *increases* TCF mediated transcription and the expression of the Wnt target genes Axin2 , LEF1 and [CyclinD1] in ReNcell VM cells . Positive_regulation CCND1 WNT1 21108734 2395809 In vitro , treatment *induced* proliferation and [cyclin D1] expression in VSMC from young ( 6 weeks old ) rats but not in cells from older rats ( 8 months old ) , even though low-density lipoprotein receptor related protein 6 and ß-catenin phosphorylation , and ß-catenin nuclear translocation demonstrated ß-catenin activation in both cell types . Positive_regulation CCND1 WNT1 21108734 2395816 Beta-catenin silencing demonstrated that *induction* of [cyclin D1] expression is ß-catenin dependent . Positive_regulation CCND1 WNT1 22204713 2612206 In conclusion , we have demonstrated that expression of cyclin D1 is linked to nodal metastases and that [cyclin D1] levels are *regulated* by signaling . Positive_regulation CCND1 WNT11 12805222 1101591 Ectopic expression of Dab2 in NIH-3T3 mouse fibroblasts attenuates canonical mediated signaling , including accumulation of beta-catenin , activation of beta-catenin/T-cell-specific factor/lymphoid enhancer binding factor 1-dependent reporter constructs , and endogenous [cyclin D1] *induction* . Positive_regulation CCND1 WNT11 15271658 1333176 Expression of the dominant interfering LRP6DeltaC transgene was sufficient to abolish the *induced* survival as well as [cyclin D1] activity and cell cycle progression . Positive_regulation CCND1 WNT11 20735988 2324324 Our results show that activation of signaling *increases* TCF mediated transcription and the expression of the Wnt target genes Axin2 , LEF1 and [CyclinD1] in ReNcell VM cells . Positive_regulation CCND1 WNT11 21108734 2395810 In vitro , treatment *induced* proliferation and [cyclin D1] expression in VSMC from young ( 6 weeks old ) rats but not in cells from older rats ( 8 months old ) , even though low-density lipoprotein receptor related protein 6 and ß-catenin phosphorylation , and ß-catenin nuclear translocation demonstrated ß-catenin activation in both cell types . Positive_regulation CCND1 WNT11 21108734 2395817 Beta-catenin silencing demonstrated that *induction* of [cyclin D1] expression is ß-catenin dependent . Positive_regulation CCND1 WNT11 22204713 2612207 In conclusion , we have demonstrated that expression of cyclin D1 is linked to nodal metastases and that [cyclin D1] levels are *regulated* by signaling . Positive_regulation CCND1 WNT16 12805222 1101596 Ectopic expression of Dab2 in NIH-3T3 mouse fibroblasts attenuates canonical mediated signaling , including accumulation of beta-catenin , activation of beta-catenin/T-cell-specific factor/lymphoid enhancer binding factor 1-dependent reporter constructs , and endogenous [cyclin D1] *induction* . Positive_regulation CCND1 WNT16 15271658 1333181 Expression of the dominant interfering LRP6DeltaC transgene was sufficient to abolish the *induced* survival as well as [cyclin D1] activity and cell cycle progression . Positive_regulation CCND1 WNT16 20735988 2324329 Our results show that activation of signaling *increases* TCF mediated transcription and the expression of the Wnt target genes Axin2 , LEF1 and [CyclinD1] in ReNcell VM cells . Positive_regulation CCND1 WNT16 21108734 2395815 In vitro , treatment *induced* proliferation and [cyclin D1] expression in VSMC from young ( 6 weeks old ) rats but not in cells from older rats ( 8 months old ) , even though low-density lipoprotein receptor related protein 6 and ß-catenin phosphorylation , and ß-catenin nuclear translocation demonstrated ß-catenin activation in both cell types . Positive_regulation CCND1 WNT16 21108734 2395822 Beta-catenin silencing demonstrated that *induction* of [cyclin D1] expression is ß-catenin dependent . Positive_regulation CCND1 WNT16 22204713 2612212 In conclusion , we have demonstrated that expression of [cyclin D1] is linked to nodal metastases and that cyclin D1 levels are *regulated* by signaling . Positive_regulation CCND1 WNT2 12805222 1101592 Ectopic expression of Dab2 in NIH-3T3 mouse fibroblasts attenuates canonical mediated signaling , including accumulation of beta-catenin , activation of beta-catenin/T-cell-specific factor/lymphoid enhancer binding factor 1-dependent reporter constructs , and endogenous [cyclin D1] *induction* . Positive_regulation CCND1 WNT2 15271658 1333177 Expression of the dominant interfering LRP6DeltaC transgene was sufficient to abolish the *induced* survival as well as [cyclin D1] activity and cell cycle progression . Positive_regulation CCND1 WNT2 20735988 2324325 Our results show that activation of signaling *increases* TCF mediated transcription and the expression of the Wnt target genes Axin2 , LEF1 and [CyclinD1] in ReNcell VM cells . Positive_regulation CCND1 WNT2 21108734 2395811 In vitro , treatment *induced* proliferation and [cyclin D1] expression in VSMC from young ( 6 weeks old ) rats but not in cells from older rats ( 8 months old ) , even though low-density lipoprotein receptor related protein 6 and ß-catenin phosphorylation , and ß-catenin nuclear translocation demonstrated ß-catenin activation in both cell types . Positive_regulation CCND1 WNT2 21108734 2395818 Beta-catenin silencing demonstrated that *induction* of [cyclin D1] expression is ß-catenin dependent . Positive_regulation CCND1 WNT2 22204713 2612208 In conclusion , we have demonstrated that expression of [cyclin D1] is linked to nodal metastases and that cyclin D1 levels are *regulated* by signaling . Positive_regulation CCND1 WNT3 12805222 1101593 Ectopic expression of Dab2 in NIH-3T3 mouse fibroblasts attenuates canonical mediated signaling , including accumulation of beta-catenin , activation of beta-catenin/T-cell-specific factor/lymphoid enhancer binding factor 1-dependent reporter constructs , and endogenous [cyclin D1] *induction* . Positive_regulation CCND1 WNT3 15271658 1333178 Expression of the dominant interfering LRP6DeltaC transgene was sufficient to abolish the *induced* survival as well as [cyclin D1] activity and cell cycle progression . Positive_regulation CCND1 WNT3 20735988 2324326 Our results show that activation of signaling *increases* TCF mediated transcription and the expression of the Wnt target genes Axin2 , LEF1 and [CyclinD1] in ReNcell VM cells . Positive_regulation CCND1 WNT3 21108734 2395812 In vitro , treatment *induced* proliferation and [cyclin D1] expression in VSMC from young ( 6 weeks old ) rats but not in cells from older rats ( 8 months old ) , even though low-density lipoprotein receptor related protein 6 and ß-catenin phosphorylation , and ß-catenin nuclear translocation demonstrated ß-catenin activation in both cell types . Positive_regulation CCND1 WNT3 21108734 2395819 Beta-catenin silencing demonstrated that *induction* of [cyclin D1] expression is ß-catenin dependent . Positive_regulation CCND1 WNT3 22204713 2612209 In conclusion , we have demonstrated that expression of cyclin D1 is linked to nodal metastases and that [cyclin D1] levels are *regulated* by signaling . Positive_regulation CCND1 WNT3A 19442631 2078654 also *increased* the expression of [cyclin D1] , known as a cell cycle regulator , as well as cell proliferation . Positive_regulation CCND1 WNT3A 22876125 2641500 Overexpression of *resulted* in upregulated expression of ß-catenin , c-Myc , and [cyclin D1] . Positive_regulation CCND1 WNT3A 24273411 2876771 [Cyclin D1] was upregulated in the *presence* of and downregulated with addition of niclosamide . Positive_regulation CCND1 WNT4 12805222 1101594 Ectopic expression of Dab2 in NIH-3T3 mouse fibroblasts attenuates canonical mediated signaling , including accumulation of beta-catenin , activation of beta-catenin/T-cell-specific factor/lymphoid enhancer binding factor 1-dependent reporter constructs , and endogenous [cyclin D1] *induction* . Positive_regulation CCND1 WNT4 15271658 1333179 Expression of the dominant interfering LRP6DeltaC transgene was sufficient to abolish the *induced* survival as well as [cyclin D1] activity and cell cycle progression . Positive_regulation CCND1 WNT4 20735988 2324327 Our results show that activation of signaling *increases* TCF mediated transcription and the expression of the Wnt target genes Axin2 , LEF1 and [CyclinD1] in ReNcell VM cells . Positive_regulation CCND1 WNT4 21108734 2395813 In vitro , treatment *induced* proliferation and [cyclin D1] expression in VSMC from young ( 6 weeks old ) rats but not in cells from older rats ( 8 months old ) , even though low-density lipoprotein receptor related protein 6 and ß-catenin phosphorylation , and ß-catenin nuclear translocation demonstrated ß-catenin activation in both cell types . Positive_regulation CCND1 WNT4 21108734 2395820 Beta-catenin silencing demonstrated that *induction* of [cyclin D1] expression is ß-catenin dependent . Positive_regulation CCND1 WNT4 22204713 2612210 In conclusion , we have demonstrated that expression of [cyclin D1] is linked to nodal metastases and that cyclin D1 levels are *regulated* by signaling . Positive_regulation CCND1 WNT5A 12612606 1063443 Wnt1 and *induce* [cyclin D1] expression through ErbB1 transactivation in HC11 mammary epithelial cells . Positive_regulation CCND1 WNT5A 17203201 1681192 Canonical signaling through Frizzled and LRP5/LRP6 receptors *activates* FGF20 , WISP1 , MYC and [CCND1] transcription for the maintenance of stem/progenitor cells , while non-canonical WNT5A signaling through Frizzled and ROR2/PTK7/RYK receptors activates the RHOA , JNK , NLK and NFAT signaling cascades for the control of tissue polarity , cell adhesion or movement . Positive_regulation CCND1 WNT6 12805222 1101595 Ectopic expression of Dab2 in NIH-3T3 mouse fibroblasts attenuates canonical mediated signaling , including accumulation of beta-catenin , activation of beta-catenin/T-cell-specific factor/lymphoid enhancer binding factor 1-dependent reporter constructs , and endogenous [cyclin D1] *induction* . Positive_regulation CCND1 WNT6 15271658 1333180 Expression of the dominant interfering LRP6DeltaC transgene was sufficient to abolish the *induced* survival as well as [cyclin D1] activity and cell cycle progression . Positive_regulation CCND1 WNT6 20735988 2324328 Our results show that activation of signaling *increases* TCF mediated transcription and the expression of the Wnt target genes Axin2 , LEF1 and [CyclinD1] in ReNcell VM cells . Positive_regulation CCND1 WNT6 21108734 2395814 In vitro , treatment *induced* proliferation and [cyclin D1] expression in VSMC from young ( 6 weeks old ) rats but not in cells from older rats ( 8 months old ) , even though low-density lipoprotein receptor related protein 6 and ß-catenin phosphorylation , and ß-catenin nuclear translocation demonstrated ß-catenin activation in both cell types . Positive_regulation CCND1 WNT6 21108734 2395821 Beta-catenin silencing demonstrated that *induction* of [cyclin D1] expression is ß-catenin dependent . Positive_regulation CCND1 WNT6 22204713 2612211 In conclusion , we have demonstrated that expression of cyclin D1 is linked to nodal metastases and that [cyclin D1] levels are *regulated* by signaling . Positive_regulation CCND1 XPO1 18769147 1962493 Translocation of [cyclin D1] into the cytoplasm is *mediated* by the nuclear exportin , whose association with cyclin D1 increases following PI3-K/Akt inhibition . Positive_regulation CCND1 XRCC5 23388457 2748203 We recently demonstrated that a moderate level of long-term fractionated radiation confers acquired radioresistance to tumor cells , which is caused by *mediated* [cyclin D1] overexpression . Positive_regulation CCND1 XRCC6 23388457 2748205 We recently demonstrated that a moderate level of long-term fractionated radiation confers acquired radioresistance to tumor cells , which is caused by *mediated* [cyclin D1] overexpression . Positive_regulation CCND1 ZFP36 16702957 1624684 *regulates* [Cyclin D1] and c-Myc mRNA stability in response to rapamycin in an Akt dependent manner via p38 MAPK signaling . Positive_regulation CCND2 AXIN2 17404238 1721618 Conditional beta cell expression of , a potent negative regulator of Wnt signaling , *led* to reduced Pitx2 and [Cyclin D2] expression by beta cells , resulting in reduced neonatal beta cell expansion and mass and impaired glucose tolerance . Positive_regulation CCND3 CCND1 17203214 1681230 Notably , GCT differentiation was associated with reduced but *increased* [cyclin D3] expression . Positive_regulation CCND3 CCND1 7742549 305957 [Cyclin D3] was never *detected* in any of the samples tested , whereas was expressed in only the 3 cases ( 1 LPL and 2 MCL ) bearing a t ( 11 ; 14 ) translocation . Positive_regulation CCND3 CDKN1C 15294951 1279030 Induction of *resulted* in increased association of cdk6 with [cyclin D3] , without receptor mediated T cell stimulation . Positive_regulation CCND3 IFI27 9693368 523669 We report that [cyclin D3/cdk4] kinase activity is *regulated* by ( kip1 ) in BALB/c 3T3 cells . Positive_regulation CCND3 MAP2K6 16815849 1606115 [Cyclin D3] expression was enhanced in a cell panel of human melanoma cell lines compared with melanocytes and was *regulated* by fibronectin mediated phosphatidylinositol 3-kinase/Akt signaling but not activity . Positive_regulation CCNE1 EPHB2 15212949 1262420 Decreasing with the pharmacological inhibitors , PD98059 and U0126 , markedly suppresses hyperoxia stimulated phospho-p53 ( Ser15 ) , p53 , and p21 ( CIP1 ) , and also *restores* the hyperoxia reduced kinase activities of [cyclin D1/E1-Cdks] . Positive_regulation CCNE1 IFI27 11593401 869820 We addressed whether down regulation was *required* to activate cyclin D1/CDK4/6 or [cyclin E/CDK2] by engineering cells with inducible p27 . Positive_regulation CCNE2 CCND1 19564413 2117431 Estrogen regulation of [cyclin E2] *requires* but not c-Myc . Positive_regulation CCNE2 RARB 18443282 1908288 The loss of signaling in the mutant mice *resulted* in reduction of [cyclin E2] , a cell cycle protein regulating transition from G ( 1 ) to S phase , and also reduction of the proneural gene Mash1 , which led to defective neurogenesis of late-born striosomal cells . Positive_regulation CCNG1 EPHB2 19542438 2099163 These results show that during mitogenic stimulation of T and B lymphocytes signaling is *critical* for two distinct processes , cell survival , mediated ( at least in part ) through phosphorylation and consequent inhibition of Bim , and cell [cycling] , which proceeds independently of Bim inactivation . Positive_regulation CCNG1 EPHB2 23687087 2805903 Conversely , downregulation of by pharmacologic and genetic approaches *attenuates* the [cycling] of Nras ( G12D/+ ) HSCs and prevents the expansion of Nras ( G12D/+ ) HSCs and myeloid progenitors . Positive_regulation CCNG1 FAS 22056764 2534099 Treatment with caspase-8 and -3 inhibitors also recovered cell [cycling] , and expression *increased* in N101-2 treated cervical cancer cells , suggesting that Fas mediated extrinsic apoptosis signaling was also activated . Positive_regulation CCNG1 FAS 23993302 2836662 We showed that *mediated* apoptosis of CD4 ( + ) FOXP3 ( high ) cells and rapid cell [cycling] of CD8 ( + ) T cells were collectively responsible for the reduced proportion of CD4 ( + ) FOXP3 ( high ) cells in expanded cultures . Positive_regulation CCNG1 FAS 9389691 467162 IFN-gamma both inhibits cell [cycling] and *induces* expression of the , resulting in subsequent apoptosis of hematopoietic progenitor cells . Positive_regulation CCNG1 FOLR1 3021316 64525 As is *involved* in substrate [cycling] , inappropriately high activity reflects an inability to adapt to malnutrition that could lead to high rates of cycling and wasteful energy expenditure at times of maximal activation of the cycle . Positive_regulation CCNG1 GPR115 2769348 117893 5 . stimulation initiates or *enhances* rhythmic pyloric [cycling] . Positive_regulation CCNG1 GPR132 2769348 117882 5 . stimulation initiates or *enhances* rhythmic pyloric [cycling] . Positive_regulation CCNG1 GPR87 2769348 117962 5 . stimulation initiates or *enhances* rhythmic pyloric [cycling] . Positive_regulation CCNG1 MAP2K6 19542438 2099169 These results show that during mitogenic stimulation of T and B lymphocytes signaling is *critical* for two distinct processes , cell survival , mediated ( at least in part ) through phosphorylation and consequent inhibition of Bim , and cell [cycling] , which proceeds independently of Bim inactivation . Positive_regulation CCNG1 MAP2K6 23687087 2805909 Conversely , downregulation of by pharmacologic and genetic approaches *attenuates* the [cycling] of Nras ( G12D/+ ) HSCs and prevents the expansion of Nras ( G12D/+ ) HSCs and myeloid progenitors . Positive_regulation CCNG1 PDE4B 9973473 596188 PDE4B RNA and protein were detected in resting PBLs , and the levels of protein *increased* with cell [cycling] . Positive_regulation CCNG1 TF 2604716 123667 The [cycling] of the transferrin receptor is therefore *regulated* by diferric via an increase in both the rate of endocytosis and exocytosis . Positive_regulation CCNG1 TLR7 19299704 2051872 Reduced c-myc expression levels limit follicular mature B cell [cycling] in *response* to signals . Positive_regulation CCNG1 TNF 8142598 242325 The possible role of *mediated* futile substrate [cycling] in increased glycolytic activity , increased energy expenditure , heat production and tissue wasting during bacterial infections is discussed . Positive_regulation CCNG2 FOXA1 22596188 2603681 is *essential* for aryl hydrocarbon receptor dependent regulation of [cyclin G2] . Positive_regulation CCNG2 FOXA1 22596188 2603684 These findings show that , but not ERa , is *essential* for AHR dependent regulation of [CCNG2] , assigning a role for FOXA1 in AHR action . Positive_regulation CCNH TNF 16874302 1600732 Upon *stimulation* of the cells by , NF-kappaB and [TFIIH] are rapidly recruited to the promoter together with additional Mediator and RNAP II , but CDK8 is lost . Positive_regulation CCR1 EPHB2 17464174 1731684 p38 MAPK and activation by 9-cis-retinoic acid *induces* chemokine receptors [CCR1] and CCR2 expression in human monocytic THP-1 cells . Positive_regulation CCR1 IL1B 20032224 2205117 Interestingly , GTE preincubation enhanced constitutive and *induced* [CCR1] , CCR2b , CCR5 , CXCR1 and CXCR2 receptor expression . Positive_regulation CCR1 TNF 10679062 668602 Stimulation of mature DCs with TGF-beta 1 also *enhanced* TNF-alpha induced down-regulation of the expressions of [CCR-1] , CCR-3 , CCR-5 , CCR-6 , and CXCR-4 , and chemotaxis to their respective ligands , while this stimulation suppressed induced expression of CCR-7 and chemotactic migratory ability to MIP-3 beta . Positive_regulation CCR1 TNF 18178867 1856464 Stimulation of ASMC with and , to a lesser extent , IFN-gamma *resulted* in an up-regulation of [CCR1] expression , which was totally suppressed by both dexamethasone or mithramycin . Positive_regulation CCR2 EPHB2 17464174 1731698 p38 MAPK and activation by 9-cis-retinoic acid *induces* chemokine receptors CCR1 and [CCR2] expression in human monocytic THP-1 cells . Positive_regulation CCR2 FOXO1 22586579 2632116 Thus , Pdk1 regulated macrophage infiltration by inhibiting *induced* [Ccr2] expression . Positive_regulation CCR2 IL1B 12555203 1051620 Moreover , TNFalpha and significantly *increase* BOB/GPR15 , [CCR2] , and V28/CX3CR1 mRNA levels in both models . Positive_regulation CCR2 RGS16 12874248 1115018 These results suggest that may *regulate* T lymphocyte activation in response to inflammatory stimuli and migration induced by CXCR4 , CCR3 , and CCR5 , but not [CCR2] or CCR7 . Positive_regulation CCR2 TNF 10623817 658378 The finding of defective [CCR2] expression in TAM , largely *dependent* on local production , is consistent with previous in vitro data on down-regulation of chemokine receptors by proinflammatory molecules . Positive_regulation CCR2 TNF 12555203 1051619 Moreover , and IL-1beta significantly *increase* BOB/GPR15 , [CCR2] , and V28/CX3CR1 mRNA levels in both models . Positive_regulation CCR2 TNF 20851151 2368665 Relaxin treatment suppressed significantly *induced* upregulation of VCAM-1 and PECAM , [CCR-2] , and MCP-1 levels and direct monocyte adhesion to HUVEC . Positive_regulation CCR3 TNF 10679062 668603 Stimulation of mature DCs with TGF-beta 1 also *enhanced* TNF-alpha induced down-regulation of the expressions of CCR-1 , [CCR-3] , CCR-5 , CCR-6 , and CXCR-4 , and chemotaxis to their respective ligands , while this stimulation suppressed induced expression of CCR-7 and chemotactic migratory ability to MIP-3 beta . Positive_regulation CCR3 TNF 11694538 896471 The transdominant IkappaBalpha mutant completely inhibited *mediated* induction of both eotaxin-1 and [CCR3] , whereas expression of constitutively active IKK-2 was sufficient to drive almost full expression of these two genes in the absence of TNF-alpha . Positive_regulation CCR3 TNF 16081847 1442858 Interestingly , *increases* ASMC surface expression of [CCR3] from 33 to 74 % . Positive_regulation CCR3 TNF 16604092 1562639 Rosmarinic acid as a downstream inhibitor of IKK-beta in *induced* upregulation of CCL11 and [CCR3] . Positive_regulation CCR3 TNF 16604092 1562641 2. In order to determine the effects of rosmarinic acid on the induced *upregulation* of CCL11 and [CCR3] in human dermal fibroblasts , we performed an enzyme linked immunosorbent assay for CCL11 and a Western blot assay for CCR3 . Positive_regulation CCR3 TNF 16604092 1562643 The *induced* expression of CCL11 and [CCR3] genes was attenuated by rosmarinic acid . Positive_regulation CCR4 CCL17 18403600 1899547 Thus , these results demonstrate that *dependent* activation of [CCR4] in macrophages plays a central role in free radical induced pulmonary injury and repair . Positive_regulation CCR4 CCL17 24563252 2924618 Mutation of a single C-terminal residue K310 within a putative CCR4 antagonist binding site ablated *activation* of [CCR4] by , but not by CCL22 , despite having no effect on the binding of either ligand . Positive_regulation CCR4 TNF 11903822 922928 *stimulated* CCR1 , [CCR4] and CCR5 mRNA expression in the same cell line . Positive_regulation CCR4 TNF 15335355 1291148 Performing immunohistochemical stainings , reverse-transcription polymerase chain reaction ( RT-PCR ) , and Western blotting , we found that *induced* [CCR4] mRNA production , but that stimulated as well as non stimulated keratinocytes expressed CCR4 . Positive_regulation CCR4 TNF 21127499 2407664 In addition , significantly *enhanced* expression of the chemokine receptor CXCR4 ( CXC motive [chemokine receptor 4] ) , which facilitated the chemotactic invasiveness of hMSCs toward stromal cell derived factor 1 (SDF-1) alpha . Positive_regulation CCR5 EPHB2 19380826 2065819 Chromatin immunoprecipitation assay revealed that Abeta activated JNK , , and PI3K *promoted* brain endothelial [CCR5] expression via transcription factor Egr-1 . Positive_regulation CCR5 MAP2K6 22506069 2583988 CCL5 and [CCR5] interaction *acts* through , ERK , which in turn activates NF-?B , resulting in the activations of avß3 integrin and contributing the migration of human osteosarcoma cells . Positive_regulation CCR5 MAP2K6 24197118 2916512 [Ccr5] signaling was *dependent* on the ( Map2k ) but not the phosphoinositide 3-kinase (Pi3k) pathway because treatment with U0126 inhibited upregulation of Erdr1 , but treatment with LY294002 increased the expression by 3.44 ± 0.92-fold ( P < 0.05 ) . Positive_regulation CCR5 STAT4 11739505 886523 A mandatory *role* for in IL-12 induction of mouse T cell [CCR5] . Positive_regulation CCR5 STAT4 11739505 886532 Considering that STAT4 is the most critical of IL-12 signaling molecules , this study investigated the *role* for in the induction of [CCR5] expression . Positive_regulation CCR5 TNF 10716998 676637 In contrast , xanthine/xanthine oxidase opposed the bacterial lipopolysaccharide- and *mediated* inhibition of CCR5 and CXCR4 mRNA expression and increased both the [CCR5] surface expression and the cell migration ( 3-fold ) in response to macrophage inflammatory protein-1beta . Positive_regulation CCR5 TNFSF10 15990565 1429557 The increase in death receptor expression and acquisition of TRAIL sensitivity *requires* the chemokine coreceptor CXCR4 but not [CCR5] or the CD4 receptor . Positive_regulation CCR6 TNF 10679062 668604 Stimulation of mature DCs with TGF-beta 1 also *enhanced* TNF-alpha induced down-regulation of the expressions of CCR-1 , CCR-3 , CCR-5 , [CCR-6] , and CXCR-4 , and chemotaxis to their respective ligands , while this stimulation suppressed induced expression of CCR-7 and chemotactic migratory ability to MIP-3 beta . Positive_regulation CCR6 TNF 11090084 754446 Among recombinant cytokines , *induced* high levels of [CCR6] mRNA expression , whereas interferon (IFN)-gamma induced low levels . Positive_regulation CCR7 EPHB2 11700037 878459 Induction of [CCR7] expression in thymocytes *requires* both signal and Ca ( 2+ ) signal . Positive_regulation CCR7 RGS16 12874248 1115019 These results suggest that may *regulate* T lymphocyte activation in response to inflammatory stimuli and migration induced by CXCR4 , CCR3 , and CCR5 , but not CCR2 or [CCR7] . Positive_regulation CCR7 SELL 22387549 2572519 Notably , ligation of and/or CCR7 did not *result* in increased [CCR7] expression levels , internalization , or re-expression . Positive_regulation CCR7 TNF 10496320 647189 down-regulated CC chemokine receptor (CCR)1 , CCR2 , and CCR5 and *up-regulated* [CCR7] mRNA levels , in agreement with functional data . Positive_regulation CCR7 TNF 15304089 1284473 [CCR7] expression was strongly *dependent* on in the case of DNCB , however , neutralization of TNF-alpha only partially reduced CCR7 expression upon NiSO ( 4 ) treatment . Positive_regulation CCS IL1B 8882609 390861 Twenty four hours after the last injection several parameters of acute inflammation were measured including zymosan induced inflammation in 6-day-old air-pouches , zymosan activated serum ( ZAS ) -induced oedema in the skin , platelet activating factor (PAF) induced neutrophilia and *induced* [corticosterone (CCS)] release . Positive_regulation CD109 SELL 9147056 429743 However , in sharp contrast to its reactivity against the silkworm LEC-IgG , p180 failed to bind LEC-IgG produced by COS-7 cells , suggesting that [p180] reacted with the silkworm LEC-IgG through the recognition of oligomannose-type oligosaccharides expressed on the silkworm products and that the lectin activity of was not *involved* in the interaction . Positive_regulation CD14 AGO2 9731066 530430 Furthermore , *induced* tumor necrosis factor (TNF) release from monocytes through interactions with [CD14] and , importantly , the addition of sCD14 enhanced this MAC-PPD stimulatory effect . Positive_regulation CD14 ANGPT2 19920349 2171814 Further analysis revealed that *induced* [CCR2+CD14hiCD11bhiF4/80-] macrophage accumulation selectively in aortic dissections and not in aortas from Il6-/- mice . Positive_regulation CD14 APOB 20472010 2288537 The aim of this research was to analyze the activation of [CD14] , TLR4 , and TLR2 in *response* to minimally modified low-density ( mmLDL ) . Positive_regulation CD14 APOB 20946675 2337954 These cells express [CD14] , toll-like receptor (TLR) 2 , and TLR4 on their surfaces , are *activated* by minimally modified low-density ( mmLDL ) and are capable of secreting pro-inflammatory cytokines . Positive_regulation CD14 CAV1 24244013 2879578 We observed that LPS interaction with [CD14] in endothelial cells *induced* Src dependent phosphorylation at Tyr ( 14 ) . Positive_regulation CD14 CCL2 19920349 2171820 In vitro , coculture of monocytes and aortic adventitial fibroblasts produced MCP-1- and IL-6 enriched conditioned medium that promoted differentiation of monocytes into macrophages , induced [CD14] and CD11b upregulation , and *induced* and MMP-9 expression . Positive_regulation CD14 CCL2 9561931 500540 However , stimulation of monocytes with *resulted* only in upregulation of the expression of [CD14] on monocytes from symptomatic asthma patients but not on monocytes from asymptomatic asthma patients and healthy individuals . Positive_regulation CD14 CD209 20642435 2322075 VD3 response on cell differentiation markers ( [CD14] inhibition and *induction* ) was two-fold higher in rs1544410_AA ( CD209 , p=0.012 ; CD14 , p=0.02 ) . Positive_regulation CD14 CD34 9715264 527758 IL-4 and CD40 ligation affect differently the differentiation , maturation , and function of human cell *derived* [CD1a+CD14-] and CD1a-CD14+ dendritic cell precursors in vitro . Positive_regulation CD14 CD40 10102646 602337 Surface [CD14] was down modulated , as a *consequence* of stimulation , on monocytes from healthy controls but not on monocytes from HIV positive patients . Positive_regulation CD14 CD40 9715264 527757 IL-4 and ligation affect differently the differentiation , maturation , and function of human CD34+ cell *derived* [CD1a+CD14-] and CD1a-CD14+ dendritic cell precursors in vitro . Positive_regulation CD14 CD40 9715264 527770 Thus , IL-4 or ligation *induced* [CD1a+CD14-] and CD1a-CD14+ DC precursors to differentiate into phenotypically close but functionally different DC populations , suggesting that DC function is primarily determined by their origin . Positive_regulation CD14 CHUK 20625918 2367947 No change in TLR4 , [CD14] or MD-2 expression was *detected* after the IgE dependent sensitization process , whereas TLR4 dependent phosphorylation of and I?B was augmented . Positive_regulation CD14 CSF1 12153694 971626 It has been demonstrated that the expression of CD16 and [CD14] is *regulated* by macrophage colony stimulating factor ( ) and GM-CSF . Positive_regulation CD14 CSF1 17482270 1848302 The ePF was demonstrated to increase expression levels of [CD14] and CD64 on isolated monocytes in the *presence* or absence of . Positive_regulation CD14 CSF2 11527988 853466 MGCs were not produced from [CD14] ( + ) /CD16 ( + ) monocytes or immature dendritic cells *induced* by granulocyte ( GM-CSF ) and interleukin (IL) 4 and only weakly produced from macrophage (M)-CSF- or GM-CSF induced macrophages . Positive_regulation CD14 CSF2 11673509 872819 IL-15 protein was found stored intracellularly and *stimulation* of [CD14] ( + ) monocytes with either LPS or resulted in mobilization of IL-15 stores to the plasma membrane . Positive_regulation CD14 CSF2 12153694 971627 It has been demonstrated that the expression of CD16 and [CD14] is *regulated* by macrophage ( M-CSF ) and GM-CSF . Positive_regulation CD14 CSF2 1380987 196025 The effect of the cytokines interferon-gamma (IFN-gamma) , tumor necrosis factor alpha (TNF alpha) , granulocyte monocyte colony stimulating factor ( GM-CSF ) and interleukin 1 (IL-1) on the expression of CD14 or HLA-DR was different : IFN-gamma strongly upregulated HLA-DR expression and down-regulated CD14 expression while TNF alpha , and IL-1 mainly *stimulated* [CD14] expression on bone marrow mononuclear cells . Positive_regulation CD14 CSF2 23234315 2711135 *enhanced* TLR4 and [CD14] expressions in microglia and subsequent LPS binding to the cell surface . Positive_regulation CD14 CSF2 23234315 2711137 GM-CSF upregulated the levels of p-ERK1/2 and p-p38 , suggesting that *induction* of TLR4 and [CD14] expression by was mediated through ERK1/2 and p38 , respectively . Positive_regulation CD14 CSF2 23234315 2711139 These results suggest that *upregulates* TLR4 and [CD14] expression in microglia through ERK1/2 and p38 , respectively , and thus promotes the LPS receptor mediated inflammation in the CNS . Positive_regulation CD14 CSF2 7504510 237430 The upregulation of [CD14] *induced* by may be clinically relevant , as CD14 is an opsonic receptor for lipopolysaccharide binding proteins , acting in the defence against Gram negative bacterial infections . Positive_regulation CD14 CSF2 7587740 336339 also *up-regulated* cell-surface expression of [CD14] on CD14brightCD16- monocytes . Positive_regulation CD14 CSF2 7691031 228708 Instead of serum , was *required* as a co-factor to restore the regulatory effect of IL-4 on [CD14-expression] . Positive_regulation CD14 CSF2 8543833 346265 or IL-3 strongly *enhanced* LPS induced histamine formation and expression of [CD14] on bone marrow derived macrophages , without affecting the expression of Mac-1 Ag . Positive_regulation CD14 CSF2 9394825 468220 De novo expression of NKRP1A and [CD14] molecules was detected upon culture of CD2- CD3- CD14- CD16- CD1a- NKRP1A- immature thymic precursors for 7 days in the *presence* of granulocyte-macrophage ( GM-CSF ) . Positive_regulation CD14 DEFB4B 10882713 730192 Thus , LPS induction of in hTBE cells *requires* [CD14] , which may complex with a TLR to ultimately activate NF-kappa B . Positive_regulation CD14 DEFB4B 11523142 852890 It has been shown that LPS induced expression of in human tracheobronchial epithelial cells *requires* [CD14] , which may complex with Toll-like receptors ( TLRs ) to ultimately activate NF-kappa B . Positive_regulation CD14 ELANE 11067940 747596 Cleavage of [CD14] on human gingival fibroblasts cocultured with activated neutrophils is *mediated* by resulting in down-regulation of lipopolysaccharide induced IL-8 production . Positive_regulation CD14 ENPEP 18332207 1898172 The *activation* of [CD14] ( + ) cells by suggests that it could play a significant role in both septic shock and fever , two of the major pathological features of S. aureus infections . Positive_regulation CD14 FCGR3B 1370419 179312 We found 1 ) increased FMLP receptor and decreased C5a receptor expression , 2 ) a normal expression of intracellular FMLP receptors after incubation with PMA , 3 ) increased loss and decreased re-expression of FMLP receptors after incubation with this peptide , 4 ) normal expression of adhesion glycoproteins CR3 ( CD11b/CD18 ) and LFA1 ( CD11a/CD18 ) , 5 ) further signs of in vivo preactivation : high expression of Fc gamma-RI ( CD64 ) and Fc gamma-RII ( CD32 ) , decreased expression of ( CD16 ) , *increased* expression of [CD14] , and low expression of HLA-DR . Positive_regulation CD14 GIF 11603926 871276 *Induction* of myocardial NOS2 and [CD14] ( not present in control ) by was approximately 2-3-fold greater in old compared to young animals . Positive_regulation CD14 GPI 9030980 405917 Both serum dependent and serum independent activation of M by LPS *require* cellular [CD14] , as evidence by blocking studies with CD14-specific antibodies . Positive_regulation CD14 GRAP2 19185295 2043896 Inhibition of activity showed minor effects on macrophage proliferation or survival , and did not *block* [CD14] , F4/80 expression . Positive_regulation CD14 HLA-E 23734938 2823703 Here , we described one case of MDS patient carrying [CD14] ( + ) CD56 ( + ) monocytes in bone marrow ( BM ) , in the *presence* of a defective expression on peripheral blood ( PB ) cells and of natural killer ( NK ) cell expansion in PB and BM . Positive_regulation CD14 HMGB1 23508573 2787821 We demonstrate that optimal dependent TLR4 activation in vitro *requires* the coreceptor [CD14] . Positive_regulation CD14 HMOX1 24651442 2925940 We showed that and CO *induced* [CD14] expression and efficiently increased expansion and differentiation of myeloid cells into macrophages . Positive_regulation CD14 ICAM1 18363879 1925399 upregulation on human monocytes by the LOS *required* surface [CD14] , TLR4 , NF-kappaB p65 and c-Jun N-terminal kinase (JNK) activity . Positive_regulation CD14 ICAM1 8945531 400306 Soluble [CD14] mediates lipopolysaccharide *induced* expression in cultured human gingival fibroblasts . Positive_regulation CD14 IDO1 21487895 2463711 In CD4 ( + ) and CD8 ( + ) T cells of the ITP patients , expressions were significantly lower than those in healthy controls , but in CD19 ( + ) and [CD14] ( + ) cells , IDO expression significantly *increased* . Positive_regulation CD14 IFNG 11854210 913511 In CD14 ( high ) HGF , IFN-gamma markedly up-regulated CD14 and MyD88 but not TLR4 protein and MD-2 mRNA expression , while in CD14 ( low ) HGF , slightly *increased* MyD88 and scarcely affected [CD14] , TLR4 protein , and MD-2 mRNA levels . Positive_regulation CD14 IFNG 11870620 918497 Priming with P. acnes led to a moderate , mainly *dependent* up-regulation of [CD14] . Positive_regulation CD14 IFNG 15248214 1271216 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 MAPK significantly reduced the production of TNFalpha and IL-1beta by rsCD154 plus *stimulated* [CD14+] synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation CD14 IFNG 15536432 1336473 The magnitude of HLA-DR upregulation on *stimulated* cord blood [CD14] + monocytes was consistently correlated with allergen induced , but not mitogen induced , lymphoproliferation at birth . Positive_regulation CD14 IFNG 2117512 139804 Neutrophils express low levels of CD14 and , in this case , *causes* an increase in the [CD14 antigen] on these cells . Positive_regulation CD14 IKBKB 20625918 2367948 No change in TLR4 , [CD14] or MD-2 expression was *detected* after the IgE dependent sensitization process , whereas TLR4 dependent phosphorylation of and I?B was augmented . Positive_regulation CD14 IKBKG 20625918 2367949 No change in TLR4 , [CD14] or MD-2 expression was *detected* after the IgE dependent sensitization process , whereas TLR4 dependent phosphorylation of and I?B was augmented . Positive_regulation CD14 IL10 12414752 1011156 In contrast , dexamethasone *inhibited* IL-10 dependent LPS induced [CD14] expression by interfering with induced signals but not by blocking IL-10 production . Positive_regulation CD14 IL10 15325277 1287140 We show here that IL-10 in the presence of M-CSF and IL-4 triggers the generation of CD14 ( + ) CD16 ( ++ ) cells from highly purified human cord blood ( CB ) and adult blood Mo. CB Mo were more sensitive to this cytokine combination than adult Mo. *induced* [CD14] ( + ) CD16 ( ++ ) cells that expressed dendritic cell markers : CD80 , CD86 , HLA-DR , and CD83 and initiated significantly decreased allogeneic mixed lymphocyte reactions ( MLRs ) . Positive_regulation CD14 IL10 15937058 1427472 Taken together , HIV-1 binding to [CD14] ( + ) monocytes can *induce* CD4 independent production at both mRNA and protein levels . Positive_regulation CD14 IL10 15944287 1416119 Our results show that LPS induced [CD14] expression on monocytic cells may be *mediated* by endogenously produced . Positive_regulation CD14 IL10 15944287 1416120 To investigate the molecular mechanism by which *enhances* [CD14] expression , both human monocytes and the promyelocytic HL-60 cells were used as model systems . Positive_regulation CD14 IL10 15944287 1416138 Finally , STAT-1 interfering RNA inhibited *induced* [CD14] expression . Positive_regulation CD14 IL10 15944287 1416142 Taken together , these results suggest that induced [CD14] *up-regulation* in human monocytic cells may be mediated by STAT-1 activation through the activation of PI3K either alone or in concert with the ERK MAPK . Positive_regulation CD14 IL10 19109192 2018932 *enhances* MD-2 and [CD14] expression in monocytes and the proteins are increased and correlated in HIV infected patients . Positive_regulation CD14 IL10 19109192 2018934 Using ELISA , we demonstrated that *had* a profound dose- and time related effect on the release of soluble MD-2 and soluble [CD14] from monocytes . Positive_regulation CD14 IL10 7520002 266255 This [CD14 molecule] was functional in that lipopolysaccharide stimulation *induced* interleukin (IL)-6 and in clones 1 and 2 but not in clone 3 . Positive_regulation CD14 IL10 7642222 317951 modestly *triggered* [CD14 antigen] expression on monocytes but not U937 . Positive_regulation CD14 IL10 9851271 554351 reduced the expression of CD40 , CD86 and HLA-DR , and *increased* the expression of [CD14] , on SF macrophages . Positive_regulation CD14 IL12A 15456540 1301182 there were also synergistic effects on inhibiting production and *inducing* [CD14] and CD64 expressions by monocytes . Positive_regulation CD14 IL12B 15456540 1301183 there were also synergistic effects on inhibiting production and *inducing* [CD14] and CD64 expressions by monocytes . Positive_regulation CD14 IL13 7542068 310926 We investigated whether [CD14] expression is *regulated* by , a member of the chromosome 5 cytokine family . Positive_regulation CD14 IL13 7545713 323049 We now investigate whether [CD14] expression could also be *regulated* by , another member of the chromosome 5 cytokine gene family . Positive_regulation CD14 IL13 8732434 374080 We found that HLA-DR , HLA-DQ , [CD14] and CD23 were differentially *regulated* by biostim and IL-4 or . Positive_regulation CD14 IL1A 1380987 196026 The effect of the cytokines interferon-gamma (IFN-gamma) , tumor necrosis factor alpha (TNF alpha) , granulocyte monocyte colony stimulating factor ( GM-CSF ) and interleukin 1 (IL-1) on the expression of CD14 or HLA-DR was different : IFN-gamma strongly upregulated HLA-DR expression and down-regulated CD14 expression while TNF alpha , GM-CSF and mainly *stimulated* [CD14] expression on bone marrow mononuclear cells . Positive_regulation CD14 IL1B 19010986 2029050 IL-6 , and cigarette smoke condensate *induced* the expression of LBP and [CD14] by airway epithelial cells . Positive_regulation CD14 IL1B 9525321 494621 Recombinant murine *induced* a transient increase in plasma levels of [CD14] with a peak at 8 h , and this increase in plasma CD14 antigen was accompanied by increased levels of CD14 messenger ribonucleic acid ( mRNA ) in all organs examined . Positive_regulation CD14 IL3 8543833 346266 Granulocyte/macrophage CSF (GM-CSF) or strongly *enhanced* LPS induced histamine formation and expression of [CD14] on bone marrow derived macrophages , without affecting the expression of Mac-1 Ag . Positive_regulation CD14 IL33 19553541 2104113 Our results show that *increases* the expression of the LPS receptor components MD2 ( myeloid differentiation protein 2 ) and TLR-4 , the soluble form of [CD14] and the MyD88 adaptor molecule . Positive_regulation CD14 IL4 11477201 841977 thus , to further clarify the differences of monocyte function and differentiation between neonates and adults , we investigated their CD14 ( + ) CD4 ( + ) and CD14 ( + ) CD16 ( + ) monocyte subpopulations , production of IL-1beta and tumor necrosis factor-alpha induced by lipopolysaccharide , and their [CD14] and CD1a phenotypic changes in *response* to and granulocyte-macrophage colony stimulating factor . Positive_regulation CD14 IL4 11527988 853467 MGCs were not produced from [CD14] ( + ) /CD16 ( + ) monocytes or immature dendritic cells *induced* by granulocyte macrophage-colony stimulating factor ( GM-CSF ) and and only weakly produced from macrophage (M)-CSF- or GM-CSF induced macrophages . Positive_regulation CD14 IL4 7540642 310120 Seven-day cultured monocytes/macrophages showed ( 1 ) diminished TNF-alpha production in response to IL-10 but not IL-4 ( 2 ) , diminished IL-1 beta production in response to both IL-4 and IL-10 , and compared with fresh monocytes ( 3 ) , diminished [CD14] expression in *response* to , and ( 4 ) a lesser increase in CD23 expression in response to IL-4 . Positive_regulation CD14 IL4 8732434 374081 We found that HLA-DR , HLA-DQ , [CD14] and CD23 were differentially *regulated* by biostim and or IL-13 . Positive_regulation CD14 IL4 9715264 527759 and CD40 ligation affect differently the differentiation , maturation , and function of human CD34+ cell *derived* [CD1a+CD14-] and CD1a-CD14+ dendritic cell precursors in vitro . Positive_regulation CD14 IL4 9715264 527771 Thus , or CD40 ligation *induced* CD1a+CD14- and [CD1a-CD14+] DC precursors to differentiate into phenotypically close but functionally different DC populations , suggesting that DC function is primarily determined by their origin . Positive_regulation CD14 IL6 15034063 1223617 *stimulated* the production of [CD14] by HepG2 hepatoma cells . Positive_regulation CD14 IL6 16934790 1627289 We found that *promoted* the generation of CD15 ( + ) granulocytic and [CD14] ( + ) monocytic cells and suppressed that of CD14 ( - ) CD1a ( + ) dendritic cells from CD36 ( - ) CD15 ( - ) CD14 ( - ) CD1a ( - ) IL-6R ( + ) myeloid progenitors . Positive_regulation CD14 IL6 1724578 175450 These findings suggest that the expression of [CD14 antigen] on the surface of U937 cells cultured with formalin killed Gram negative bacteria is *induced* by and can be explained on the basis of the autocrine mechanism of interleukin-6 . Positive_regulation CD14 IL6 7520002 266256 This [CD14 molecule] was functional in that lipopolysaccharide stimulation *induced* and IL-10 in clones 1 and 2 but not in clone 3 . Positive_regulation CD14 IL6 9176258 433699 *increased* [CD14] expression in both BAM and PBM but exerted different effects on CD14 distribution in these cell types . Positive_regulation CD14 IL6 9885903 558342 Inducible expression of nuclear factor *increases* endogenous gene expression of macrophage inflammatory protein-1 alpha , osteopontin and [CD14] in a monocytic leukemia cell line . Positive_regulation CD14 IL6 9885903 558344 We demonstrated that inducible expression of is able to *increase* endogenous gene expression of macrophage inflammatory protein (MIP)-1 alpha , osteopontin and [CD14] in M1 cells . Positive_regulation CD14 IL9 15456540 1301184 there were also synergistic effects on inhibiting production and *inducing* [CD14] and CD64 expressions by monocytes . Positive_regulation CD14 ITGA4 9744992 533312 in [CD14] ( + ) cells also the expression of ( alpha4 subunit of late activation antigen-4 , VLA-4 ) *increased* after alendronate treatment . Positive_regulation CD14 JUN 10768925 685058 Since TGF-beta1 pretreatment inhibited LPS stimulated expression of c-fos and c-jun genes and also the binding of nuclear proteins to the consensus sequence of the binding site for activation protein 1 (AP-1) , a heterodimer of c-Fos and c-Jun , in the cells , TGF-beta1 inhibition of [CD14] expression may be a *consequence* of downregulation of . Positive_regulation CD14 JUN 18180316 1856478 Further investigations using transcription factor activity assays and gel shift assays revealed that high glucose *augmented* LPS stimulated [CD14] expression by enhancing transcription factor nuclear factor kappaB (NFkappaB) and activities . Positive_regulation CD14 KLF4 17762869 1795014 Consistently , can rescue PU.1-/- fetal liver cells along the monocytic lineage and can *activate* the monocytic-specific [CD14] promoter . Positive_regulation CD14 LBP 1379976 193087 The binding of endotoxin to [CD14] was *mediated* by a present in serum . Positive_regulation CD14 LBP 1380063 193142 Our results indicate that ( a ) both stimulatory and nonstimulatory ligands can bind to [CD14] in the *presence* of ; Positive_regulation CD14 LBP 1708813 155183 Interaction of [CD14] with LPS in the *presence* of or serum also caused a dramatic , transient increase in the adhesive activity of CR3 ( CD11b/CD18 ) on PMN . Positive_regulation CD14 LBP 7685797 219815 In the *presence* of , LPS strongly activates monocytes via [CD14] as measured by TNF secretion . Positive_regulation CD14 LBP 7693705 234172 was *required* for LPS binding to [CD14] . Positive_regulation CD14 LEP 22768838 2623626 Here , we demonstrate that *upregulation* of [CD14] by mediated signaling is critical to hyperreactivity against endotoxin during NASH progression . Positive_regulation CD14 LEP 22768838 2623627 Administering in chow fed mice *caused* increased hepatic expression of [CD14] via STAT3 signaling , resulting in hyperreactivity against low-dose LPS without steatosis . Positive_regulation CD14 LPA 20472010 2288538 The aim of this research was to analyze the activation of [CD14] , TLR4 , and TLR2 in *response* to minimally modified low-density ( mmLDL ) . Positive_regulation CD14 LPA 20946675 2337955 These cells express [CD14] , toll-like receptor (TLR) 2 , and TLR4 on their surfaces , are *activated* by minimally modified low-density ( mmLDL ) and are capable of secreting pro-inflammatory cytokines . Positive_regulation CD14 LTA 11329450 808114 PepG and also *caused* increased expression of [CD14] , whereas LPS down-regulated this molecule . Positive_regulation CD14 LTA 14500472 1143930 ( or pneumococcal teichoic acid ) *stimulated* neither [CHO/CD14/TLR2] nor CHO/CD14/TLR4 cells even at high concentrations . Positive_regulation CD14 LTA 20713893 2312960 In contrast to human blood cells , TLR2 transfected human embryonic kidney 293 cells could be activated only by wt-LTA , whereas activation of these cells by *required* the additional expression of TLR6 and [CD14] , suggesting that activation of human embryonic kidney 293 cells expressing solely TLR2 is probably mediated by residual lipoproteins in wt-LTA . Positive_regulation CD14 LY86 12322892 991433 CD200 is up-regulated in rodent transplantation models where successful inhibition of rejection is accomplished , and is believed to signal immunosuppression following engagement of a receptor , CD200R , on macrophages and/or gammadelta T-cell receptor ( gammadelta TCR+ cells MD-1 is implicated in controlling expression of costimulatory molecules including CD80/CD86 which induce an immunorejection response , and thus inhibition of MD-1 expression also facilitates increased graft survival also *stabilizes* expression of [CD14] , part of the receptor complex for LPS . Positive_regulation CD14 MEF2D 12213324 985354 We have recently reported that expression of protein increases during the differentiation of HL60 promyeloid cells to monocyte and that the upregulation of the protein is *required* for [CD14] expression during the differentiation [ Mol. Immunol. 36 ( 1999 ) 1209 ] . Positive_regulation CD14 MMP9 19920349 2171821 In vitro , coculture of monocytes and aortic adventitial fibroblasts produced MCP-1- and IL-6 enriched conditioned medium that promoted differentiation of monocytes into macrophages , *induced* [CD14] and CD11b upregulation , and induced MCP-1 and expression . Positive_regulation CD14 MSC 21838603 2524250 Moreover , the presence of impaired major histocompatibility complex ( MHC ) I and II , CD11c and CCR5 expression and *induced* [CD14] and CD64 expression on monocytes . Positive_regulation CD14 NAMPT 17237424 1690066 In [CD14] ( + ) monocytes , *induces* the production of IL-1beta , TNF-alpha , and especially IL-6 . Positive_regulation CD14 NCOA3 17943182 1874201 Small interfering RNA silencing of the vitamin D receptor or *blocked* the induction of cathelicidin and [CD14] by 1,25D3 . Positive_regulation CD14 NFKB1 11460313 838806 In conclusion , we demonstrate that angelan *induces* activation through the [CD14] and CR3 membrane receptor and p38 kinase that is critically involved in the signal transduction leading to NF-kappa B/Rel activation in murine macrophages . Positive_regulation CD14 NFKB1 15222977 1264716 In conclusion , we demonstrate that PCSC *induces* activation and iNOS expression through the [CD14] , TLR4 , and CR3 membrane receptor and p38 kinase which is critically involved in the signal transduction leading to NF-kappaB/Rel activation in murine macrophages . Positive_regulation CD14 NFKB1 16879219 1593849 Antirat [CD14] and antirat TLR-4 antibodies inhibited LPS induced NFkappaB activation , and a inhibitor *suppressed* LPS induced decreased PS expression in both cells . Positive_regulation CD14 NFKB1 18180316 1856479 Further investigations using transcription factor activity assays and gel shift assays revealed that high glucose *augmented* LPS stimulated [CD14] expression by enhancing transcription factor and activator protein-1 (AP-1) activities . Positive_regulation CD14 NOS2 15222977 1264717 In conclusion , we demonstrate that PCSC *induces* NF-kappaB/Rel activation and expression through the [CD14] , TLR4 , and CR3 membrane receptor and p38 kinase which is critically involved in the signal transduction leading to NF-kappaB/Rel activation in murine macrophages . Positive_regulation CD14 OR2T1 23152895 2699884 As expected , LPS alone *led* to sustained increases in [CD14] and CD11b expression . Positive_regulation CD14 PIK3CA 15944287 1416143 Taken together , these results suggest that IL-10 induced [CD14] up-regulation in human monocytic cells may be *mediated* by STAT-1 activation through the activation of either alone or in concert with the ERK MAPK . Positive_regulation CD14 PIK3R1 15944287 1416144 Taken together , these results suggest that IL-10 induced [CD14] up-regulation in human monocytic cells may be *mediated* by STAT-1 activation through the activation of either alone or in concert with the ERK MAPK . Positive_regulation CD14 PTGES 22466648 2589006 activation , PGE2 production , and edema formation *required* [CD14] ( a component of the LPS receptor ) and NFAT . Positive_regulation CD14 PTK2 8572247 340725 Inhibitors of protein kinase C and *prevented* the upregulation of CD14 by LPS but did not effect the upregulation of [CD14] by FBS . Positive_regulation CD14 PTK6 8572247 340726 Inhibitors of protein kinase C and *prevented* the upregulation of [CD14] by LPS but did not effect the upregulation of CD14 by FBS . Positive_regulation CD14 PTK7 8572247 340727 Inhibitors of protein kinase C and *prevented* the upregulation of [CD14] by LPS but did not effect the upregulation of CD14 by FBS . Positive_regulation CD14 PTPN22 19388934 2106428 Finally , decreased expression of stem cell markers ( CD117 , CXCR4 ) and *increased* lineage associated CD11b and [CD14] expression . Positive_regulation CD14 REL 11460313 838807 In conclusion , we demonstrate that angelan *induces* NF-kappa activation through the [CD14] and CR3 membrane receptor and p38 kinase that is critically involved in the signal transduction leading to NF-kappa B/Rel activation in murine macrophages . Positive_regulation CD14 REL 15222977 1264718 In conclusion , we demonstrate that PCSC *induces* activation and iNOS expression through the [CD14] , TLR4 , and CR3 membrane receptor and p38 kinase which is critically involved in the signal transduction leading to NF-kappaB/Rel activation in murine macrophages . Positive_regulation CD14 RELA 11460313 838808 In conclusion , we demonstrate that angelan *induces* activation through the [CD14] and CR3 membrane receptor and p38 kinase that is critically involved in the signal transduction leading to NF-kappa B/Rel activation in murine macrophages . Positive_regulation CD14 RELA 15222977 1264719 In conclusion , we demonstrate that PCSC *induces* activation and iNOS expression through the [CD14] , TLR4 , and CR3 membrane receptor and p38 kinase which is critically involved in the signal transduction leading to NF-kappaB/Rel activation in murine macrophages . Positive_regulation CD14 RELA 16879219 1593850 Antirat [CD14] and antirat TLR-4 antibodies inhibited LPS induced NFkappaB activation , and a inhibitor *suppressed* LPS induced decreased PS expression in both cells . Positive_regulation CD14 RELA 18180316 1856480 Further investigations using transcription factor activity assays and gel shift assays revealed that high glucose *augmented* LPS stimulated [CD14] expression by enhancing transcription factor and activator protein-1 (AP-1) activities . Positive_regulation CD14 RELB 15315978 1333341 Here we demonstrate that the nuclear factor-kappaB (NF-kappaB) *regulates* the generation of monocytic [CD14] ( + ) CD11b ( + ) precursors of interstitial DCs from human hematopoietic progenitors . Positive_regulation CD14 SCARA3 14521944 1148216 Activation of signaling pathways by putative ligands *requires* [CD14] but not SR-A . Positive_regulation CD14 SCARA5 14521944 1148217 Activation of signaling pathways by putative ligands *requires* [CD14] but not SR-A . Positive_regulation CD14 SELE 8751905 377224 With Escherichia coli LPS , tumor necrosis factor alpha activation requires membrane bound [CD14] and expression *requires* soluble CD14 ( sCD14 ) . Positive_regulation CD14 SERPINA1 17448722 1749600 *regulates* [CD14] expression and soluble CD14 levels in human monocytes in vitro . Positive_regulation CD14 SFTPD 15814723 1393130 *regulates* soluble [CD14] through matrix metalloproteinase-12 . Positive_regulation CD14 SP1 17203216 1681232 Indeed , we found that mithramycin A , a specific inhibitor of Sp1 , inhibited both VD3- and decitabine induced upregulation of CD14 , which is in line with previous data showing that is *critical* for [CD14] promoter activity . Positive_regulation CD14 SP100 12496149 1033494 ( iv ) *enhances* the binding of radiolabeled [CD14] to LPS coated wells . Positive_regulation CD14 STAT1 15944287 1416117 *mediates* the stimulatory effect of IL-10 on [CD14] expression in human monocytic cells . Positive_regulation CD14 STAT1 15944287 1416141 Taken together , these results suggest that IL-10 induced [CD14] up-regulation in human monocytic cells may be *mediated* by activation through the activation of PI3K either alone or in concert with the ERK MAPK . Positive_regulation CD14 SULT1A1 9380033 465911 Three lines of evidence show that the mechanism of [CD14] expression *induced* by differs from that induced by LPS : ( i ) unlike LPS , STP can stimulate BMC from LPS-unresponsive C3H/HeJ mice , ( ii ) LPS and STP effects are additive at a saturating dose of LPS , and ( iii ) the protein kinase inhibitor K-252a inhibits the LPS induced but not STP induced stimulation . Positive_regulation CD14 TAL1 18436863 1920981 Decreased expression in CMP *resulted* in rare erythroid colonies , in a 2-3 fold reduction of GM colony number in clonogenic assays and in a 3.6-5.6 decreased production of [CD14] ( + ) CD15 ( + ) GM cells in liquid culture . Positive_regulation CD14 TBCE 12515659 1027850 To explore the effect of LPS on the expression of [CD14] and the *activation* of . Positive_regulation CD14 TLR1 23679126 2805762 stimulation significantly *increased* IDO protein level in [CD14] ( + ) , CD56 ( + ) , CD1c ( + ) , CD11c ( + ) , and CD123 ( + ) myeloid cells . Positive_regulation CD14 TLR10 23679126 2805770 stimulation significantly *increased* IDO protein level in [CD14] ( + ) , CD56 ( + ) , CD1c ( + ) , CD11c ( + ) , and CD123 ( + ) myeloid cells . Positive_regulation CD14 TLR2 19637338 2182899 Our study shows that Cd14-promoter polymorphisms affect [CD14] expression and confirms the protective effect of CD14 against experimental IBD , potentially *mediated* by and TLR4 dependent effects on intestinal barrier function . Positive_regulation CD14 TLR2 23679126 2805763 stimulation significantly *increased* IDO protein level in [CD14] ( + ) , CD56 ( + ) , CD1c ( + ) , CD11c ( + ) , and CD123 ( + ) myeloid cells . Positive_regulation CD14 TLR3 23679126 2805764 stimulation significantly *increased* IDO protein level in [CD14] ( + ) , CD56 ( + ) , CD1c ( + ) , CD11c ( + ) , and CD123 ( + ) myeloid cells . Positive_regulation CD14 TLR4 11209057 787366 sCD14 mediated cellular activation does not require membrane [CD14] expression , depends on a region of CD14 that is not involved in lipopolysaccharide binding , and *requires* functional . Positive_regulation CD14 TLR4 15349893 1292351 In the liver , P. acnes priming was associated with up-regulation of and MD-2 proteins , and subsequent LPS challenge further *increased* MD-2 and [CD14] mRNA levels . Positive_regulation CD14 TLR4 16982271 1617106 These results demonstrate that odontoblast-like cells express [CD14] and TLR4 , and that LPS induced VEGF expression is *mediated* , at least in part , by signaling . Positive_regulation CD14 TLR4 19637338 2182900 Our study shows that Cd14-promoter polymorphisms affect [CD14] expression and confirms the protective effect of CD14 against experimental IBD , potentially *mediated* by TLR2- and dependent effects on intestinal barrier function . Positive_regulation CD14 TLR4 23201091 2730684 In conclusion , these studies show for the first time that LPS causes an increase in intestinal permeability via an intracellular mechanism involving *dependent* up-regulation of [CD14] membrane expression . Positive_regulation CD14 TLR4 23416151 2759886 The expression of [CD14] , a co-receptor of TLR4 , was *induced* by MCAO , while the expression of remained unchanged . Positive_regulation CD14 TLR4 23508573 2787820 We demonstrate that optimal HMGB1 dependent activation in vitro *requires* the coreceptor [CD14] . Positive_regulation CD14 TLR4 23679126 2805765 stimulation significantly *increased* IDO protein level in [CD14] ( + ) , CD56 ( + ) , CD1c ( + ) , CD11c ( + ) , and CD123 ( + ) myeloid cells . Positive_regulation CD14 TLR5 23679126 2805766 stimulation significantly *increased* IDO protein level in [CD14] ( + ) , CD56 ( + ) , CD1c ( + ) , CD11c ( + ) , and CD123 ( + ) myeloid cells . Positive_regulation CD14 TLR6 23679126 2805771 stimulation significantly *increased* IDO protein level in [CD14] ( + ) , CD56 ( + ) , CD1c ( + ) , CD11c ( + ) , and CD123 ( + ) myeloid cells . Positive_regulation CD14 TLR7 23679126 2805767 stimulation significantly *increased* IDO protein level in [CD14] ( + ) , CD56 ( + ) , CD1c ( + ) , CD11c ( + ) , and CD123 ( + ) myeloid cells . Positive_regulation CD14 TLR8 23679126 2805768 stimulation significantly *increased* IDO protein level in [CD14] ( + ) , CD56 ( + ) , CD1c ( + ) , CD11c ( + ) , and CD123 ( + ) myeloid cells . Positive_regulation CD14 TLR9 23679126 2805769 stimulation significantly *increased* IDO protein level in [CD14] ( + ) , CD56 ( + ) , CD1c ( + ) , CD11c ( + ) , and CD123 ( + ) myeloid cells . Positive_regulation CD14 TNF 10777809 686978 *Role* of microglial derived in mediating [CD14] transcription and nuclear factor kappa B activity in the brain during endotoxemia . Positive_regulation CD14 TNF 10843415 700078 Only and the 29E strain *caused* significant increases in [CD14] expression . Positive_regulation CD14 TNF 20729207 2330376 We showed that the production of a by macrophages in response to Toxoplasma gondii glycosylphosphatidylinositols ( GPIs ) *requires* the expression of both Toll-like receptors TLR2 and TLR4 , but not of their co-receptor [CD14] . Positive_regulation CD14 TNF 24489448 2884807 At higher doses of both LPS forms ( 100-1000 ng/mL ) , release *required* [CD14] to much lower extent . Positive_regulation CD14 TNF 7528733 291388 [Anti-CD14] monoclonal antibodies MY4 and 3C10 inhibited LPS binding protein and CD14 dependent *activation* of production by LPS at LPS concentrations up to approximately 1.0 ng/ml. R-HDL ( 2 mg of protein per ml ) blocked TNF-alpha production by LPS from both smooth- and rough-type gram negative bacteria at concentrations up to 100 ng of LPS per ml but had little effect on heat killed gram positive Staphylococcus aureus and no effect on other LPS independent stimuli tested . Positive_regulation CD14 TNF 7681399 214251 Moreover , induced a moderate *increase* of [CD14] surface antigen expression , used as a phenotypic marker of monocyte/macrophage differentiation . Positive_regulation CD14 TNF 7685250 219749 Lipopolysaccharide binding protein and [CD14] interaction *induces* generation and neutrophil sequestration in lungs after intratracheal endotoxin . Positive_regulation CD14 TNF 8751905 377225 With Escherichia coli LPS , alpha activation *requires* membrane bound [CD14] and E-selectin expression requires soluble CD14 ( sCD14 ) . Positive_regulation CD14 TNF 8921956 396876 Furthermore , exogenous recombinant induced in vivo and in vitro *enhanced* [CD14] expression in Lpsn , Lpsd and also in TNF receptor 2-deficient (TNFR2-/-) mice , but failed to do so in TNFR1-/- mice , showing that TNFR1 mediates the effect of TNF on CD14 . Positive_regulation CD14 TNF 9353071 461324 *induced* a transient increase in levels of [CD14] in plasma with a peak at 6 to 8 h , and this increase in levels of CD14 antigen in plasma was accompanied by increased levels of CD14 mRNA in lung , liver , and kidney . Positive_regulation CD14 TNF 9529106 496476 The results demonstrate that significantly *increases* the LPS induced release of oxygen radicals in neutrophils through the upregulation of cell surface [CD14] . Positive_regulation CD14 TNF 9731066 530429 Furthermore , MAC-PPD *induced* release from monocytes through interactions with [CD14] and , importantly , the addition of sCD14 enhanced this MAC-PPD stimulatory effect . Positive_regulation CD14 TNFRSF1A 23620528 2819106 Conversely , inhibition of activity by a TNFR1 neutralizing antibody *inhibits* CD137L mediated cell adhesion , cell death , [CD14] expression , and IL-8 production . Positive_regulation CD14 TNFRSF1A 8921956 396877 Furthermore , exogenous recombinant tumor necrosis factor (TNF) induced in vivo and in vitro enhanced CD14 expression in Lpsn , Lpsd and also in TNF receptor 2-deficient (TNFR2-/-) mice , but failed to do so in TNFR1-/- mice , showing that *mediates* the effect of TNF on [CD14] . Positive_regulation CD14 TNFSF11 12958198 1138273 Our results demonstrate that *induces* the migration of MonoMac-6 monocytic cells as well as human freshly isolated total peripheral blood mononuclear cells ( PBMC ) and [CD14+] purified PBMC . Positive_regulation CD14 TNFSF11 23572233 2804268 In addition , cystatin C , Z-RLVG-CHN2 , and E-64 inhibited osteoclastic differentiation of *stimulated* [CD14] ( + ) human monocytes . Positive_regulation CD14 TXN 11342447 812733 Truncated ( Trx80 ) induces production of interleukin-12 and *enhances* [CD14] expression in human monocytes . Positive_regulation CD14 TYR 17977838 1850283 These findings reveal *roles* of Phe ( 121 ) and ( 131 ) in TLR4 independent interactions of human MD-2 with E . [CD14] and , together with Phe ( 126 ) , in activation of TLR4 by bound E . MD-2 . Positive_regulation CD14 VDR 17943182 1874200 Small interfering RNA silencing of the or SRC3 *blocked* the induction of cathelicidin and [CD14] by 1,25D3 . Positive_regulation CD14 VIT 15766397 1383652 To observe the 1 , 25-dihydroxy *induced* [CD14] expression in human U937 cell line and the reaction of the cells to LPS stimulation following the induction . Positive_regulation CD151 EPHB2 22684562 2611662 Taken together , it was concluded that CD151 promotes the proliferation and migration of PC3 cells through the formation of [CD151-integrin] complex and the *activation* of phosphorylated . Positive_regulation CD160 TNF 19559672 2110572 TNF-alpha augmented the IL-15 induced expression of [NK1] .1 and CD122 in mature NK cells , and alone also *induced* NK cell maturation as well as IL-15 . Positive_regulation CD19 CD22 10485654 644323 Biochemical studies with B cells from CD19-deficient and CD22-deficient mice indicated that these two regulatory molecules influenced each other 's functions : expression negatively *regulated* [CD19] tyrosine phosphorylation , while optimal CD22 function was dependent on CD19 expression . Positive_regulation CD1A TLR7 18310500 1919404 Sorafenib , but not sunitinib , inhibits function of DCs , characterized by reduced secretion of cytokines and expression of [CD1a] , major histocompatibility complex , and costimulatory molecules in *response* to ligands as well as by their impaired ability to migrate and stimulate T-cell responses . Positive_regulation CD1C TLR7 23679126 2805777 stimulation significantly *increased* IDO protein level in CD14 ( + ) , CD56 ( + ) , [CD1c] ( + ) , CD11c ( + ) , and CD123 ( + ) myeloid cells . Positive_regulation CD1D TNF 15708985 1373270 TNF-alpha treatment of uninfected endothelial cells had only a modest effect on CD1d expression , suggesting that optimal [CD1d] upregulation *requires* both infection and signaling . Positive_regulation CD2 IL1B 9829620 551114 AA-2G synergistically stimulated the [anti-SRBC] PFC responses in the *presence* of , IL-2 , IL-5 or CAS , IL-1beta among these cytokines being most highly affected . Positive_regulation CD2 ITGB2 7608563 311952 *Activation* of by CBR [LFA-1/2] was further confirmed by stimulation of neutrophil binding to fibrinogen , a ligand for Mac-1 . Positive_regulation CD2 ITGB2 9574521 502480 Our results demonstrate that *activation* of binding to ICAM-1 by CBR [LFA-1/2] , in contrast to inside-out signaling mechanisms , does not require protein kinase C activation or protein phosphatase 2A activity nor is it affected by agents that interfere with reorganization of the cytoskeleton . Positive_regulation CD2 TNF 8215640 231611 Combination [anti-CD2] and anti-CD3 monoclonal antibodies *induce* tolerance while altering interleukin-2 , interleukin-4 , , and transforming growth factor-beta production . Positive_regulation CD200 EPHB2 18008004 1832090 [CD200] is *induced* by and is a potential therapeutic target in melanoma . Positive_regulation CD200 MAP2K6 24183830 2875536 Moreover , UO126 , a inhibitor , *reduces* [CD200] expression . Positive_regulation CD200 TLR7 20833375 2319014 Thus [CD200] is *induced* by , NOD2- , and NALP3 mediated pathways , limiting their function and protecting the host from excessive inflammation . Positive_regulation CD200 TNF 19386363 2081980 All the above findings suggest that IFN-gamma and *induce* [CD200] expression through a 5 ' upstream enhancer and that NF-kappaB , STAT1 and IRF-1 play pivotal roles in this process . Positive_regulation CD209 CD14 20642435 2322076 VD3 response on cell differentiation markers ( inhibition and [CD209] *induction* ) was two-fold higher in rs1544410_AA ( CD209 , p=0.012 ; CD14 , p=0.02 ) . Positive_regulation CD209 JAG1 19890038 2165914 The expression of [DC-SIGN/CD209] in immune related tissues can be significantly *up-regulated* by exogenous and IL-4 . Positive_regulation CD209 TNF 18405996 1914219 [DC-SIGN] enhances infection of cells with glycosylated West Nile virus in vitro and virus replication in human dendritic cells *induces* production of IFN-alpha and . Positive_regulation CD209 TNF 20080962 2218739 These results suggest that allergens are able to interact with [DC-SIGN] and *induce* expression in MDDCs via , in part , Raf-1 signaling pathways . Positive_regulation CD22 ARID4B 19150402 2038024 Moreover , forced expression of *leads* to constitutive [CD22] tyrosine phosphorylation and decreased Ca ( 2+ ) response in B cells . Positive_regulation CD22 BCR 17631277 1775246 Because CD22 mediated signal regulation requires phosphorylation of [CD22] by Lyn that localizes in lipid rafts and is *activated* by , synthetic glycan ligand regulates localization of CD22 crucial for signal regulation . Positive_regulation CD22 BCR 9601638 506573 Surprisingly , CD22 remains capable of regulating the ERK2 and JNK pathways in lyn-/- B cells , which may relate to the small residual increase in *induced* [CD22] phosphorylation . Positive_regulation CD22 CD19 11339363 765248 complex formation also *regulates* phosphorylation of [CD22] and FcgammaRIIB , which inhibit B cell signal transduction through the recruitment of the SHPI and SHIP phosphatases . Positive_regulation CD22 CD19 17223015 1703663 *regulates* [CD22] phosphorylation by augmenting Lyn kinase activity , while CD22 inhibits CD19 phosphorylation via SHP-1 . Positive_regulation CD22 CD38 11967115 933042 The lack of association or phosphorylation of [CD22] *induced* by and CD40 cross linking indicates that CD22 may not downregulate the activation induced by these two molecules . Positive_regulation CD22 CD40 11967115 933041 The lack of association or phosphorylation of [CD22] *induced* by CD38 and cross linking indicates that CD22 may not downregulate the activation induced by these two molecules . Positive_regulation CD22 CD40 16393971 1505961 B cell antigen receptor and differentially *regulate* [CD22] tyrosine phosphorylation . Positive_regulation CD22 CD79A 17631277 1775247 Because CD22 mediated signal regulation requires phosphorylation of [CD22] by Lyn that localizes in lipid rafts and is *activated* by , synthetic glycan ligand regulates localization of CD22 crucial for signal regulation . Positive_regulation CD22 CD79A 9601638 506574 Surprisingly , CD22 remains capable of regulating the ERK2 and JNK pathways in lyn-/- B cells , which may relate to the small residual increase in *induced* [CD22] phosphorylation . Positive_regulation CD22 CD79B 17631277 1775248 Because CD22 mediated signal regulation requires phosphorylation of [CD22] by Lyn that localizes in lipid rafts and is *activated* by , synthetic glycan ligand regulates localization of CD22 crucial for signal regulation . Positive_regulation CD22 CD79B 9601638 506575 Surprisingly , CD22 remains capable of regulating the ERK2 and JNK pathways in lyn-/- B cells , which may relate to the small residual increase in *induced* [CD22] phosphorylation . Positive_regulation CD22 CMAHP 17296732 1718783 Such repression *caused* activation dependent dynamic reduction of [CD22] ligand expression without losing alpha2,6 linked sialylation in germinal centers . Positive_regulation CD22 HDAC1 19150402 2038027 Moreover , forced expression of *leads* to constitutive [CD22] tyrosine phosphorylation and decreased Ca ( 2+ ) response in B cells . Positive_regulation CD22 HDAC2 19150402 2038028 Moreover , forced expression of *leads* to constitutive [CD22] tyrosine phosphorylation and decreased Ca ( 2+ ) response in B cells . Positive_regulation CD22 LYN 11339363 765249 complex formation also *regulates* phosphorylation of [CD22] and FcgammaRIIB , which inhibit B cell signal transduction through the recruitment of the SHPI and SHIP phosphatases . Positive_regulation CD22 LYN 9586639 504536 The biochemical basis of this complex trait involves a pathway *requiring* to phosphorylate [CD22] and recruit SHP-1 to the CD22/BCR complex . Positive_regulation CD22 PTPN6 8627166 355813 Transient expression of CD22 and a null mutant of ( PTP-1CM ) in COS cells *resulted* in an increase in tyrosyl phosphorylation of [CD22] and its interaction with PTP-1CM . Positive_regulation CD22 PTPRC 10228003 610547 *regulates* tyrosine phosphorylation of [CD22] and its association with the protein tyrosine phosphatase SHP-1 . Positive_regulation CD22 PTPRC 10228003 610553 These results indicate that *regulates* tyrosine phosphorylation of [CD22] and binding of SHP-1 . Positive_regulation CD22 RBBP4 19150402 2038029 Moreover , forced expression of *leads* to constitutive [CD22] tyrosine phosphorylation and decreased Ca ( 2+ ) response in B cells . Positive_regulation CD22 RBBP7 19150402 2038030 Moreover , forced expression of *leads* to constitutive [CD22] tyrosine phosphorylation and decreased Ca ( 2+ ) response in B cells . Positive_regulation CD22 SAP130 19150402 2038026 Moreover , forced expression of *leads* to constitutive [CD22] tyrosine phosphorylation and decreased Ca ( 2+ ) response in B cells . Positive_regulation CD22 SAP30 19150402 2038023 Moreover , forced expression of *leads* to constitutive [CD22] tyrosine phosphorylation and decreased Ca ( 2+ ) response in B cells . Positive_regulation CD22 SIN3A 19150402 2038025 Moreover , forced expression of *leads* to constitutive [CD22] tyrosine phosphorylation and decreased Ca ( 2+ ) response in B cells . Positive_regulation CD226 ITGB2 10591186 572558 In addition , cross linking of *induces* tyrosine phosphorylation of [DNAM-1] , for which the Fyn protein tyrosine kinase is responsible . Positive_regulation CD226 TNF 2541074 110465 Exogenous IL-2 or , to a lesser extent , added to mixed lymphocyte cultures ( MLC ) *augmented* both [TLiSA1] antigen expression and cytotoxic function by the resulting blast cells ; Positive_regulation CD244 FAS 8864141 388948 Immunoprecipitation studies of *stimulated* human Jurkat and murine [2B4] .11 T cells revealed activation of the Src-family tyrosine kinases Lck and Fyn . Positive_regulation CD244 TNF 16684368 1663369 Blockade of beta2 integrins and membrane bound IL-15 inhibited TNF production , whereas synthesis *increased* in the presence of anti-CD48 and [anti-CD244] ( 2B4 ) monoclonal antibodies . Positive_regulation CD27 TNF 10221513 609429 In contrast to results described with B-type chronic lymphocytic leukemia , also characterized by high levels of circulating TNF , none of the tested samples showed a regulation of CD80 , CD86 , [CD27] and CD70 in *response* to . Positive_regulation CD274 EPHB2 18941206 1978140 NAC blocked the activation of JNK and down-regulation of , but both z-VAD-fmk ( N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone ) and ZB4 did not *inhibit* JNK activation of [B7-H1] stimulation . Positive_regulation CD274 MAP2K6 20814675 2324958 inhibitors , including UO126 and AZD6244 , *reduced* [B7-H1] expression and restored CTL mediated lysis of blast cells . Positive_regulation CD274 TLR7 18317010 1881004 Here we demonstrate that HIV-1 derived ligands can *induce* MyD88 dependent upregulation of [PD-L1] on plasmacytoid dendritic cells , myeloidic dendritic cells and monocytes . Positive_regulation CD274 TLR7 19769973 2195561 Inhibition of phosphoinositide 3 kinase with LY294002 blocked the *up-regulation* of [PD-L1] by ligands and the TLR3-specific induction of TRAIL and type 1 IFNs . Positive_regulation CD274 TNF 10549624 565005 [B7h] , a novel costimulatory homolog of B7.1 and B7.2 , is *induced* by . Positive_regulation CD274 TNF 10549624 565006 These data define a novel costimulatory ligand for T cells and suggest that *induction* of [B7h] by may function as a mechanism to directly augment recognition of self during inflammation . Positive_regulation CD274 TNF 12234299 988838 *up-regulated* C3 , CD40 and [B7h] production by PTEC . Positive_regulation CD274 TNF 16129490 1507337 Flow cytometric analysis revealed that [B7-H1] but not B7-DC constitutively expresses on TECs , and the B7-H1 protein expression was profoundly *up-regulated* by the stimulation of with a dose dependent manner . Positive_regulation CD274 TNF 17507101 1751013 However , the surface expression of [PD-L1] was *induced* by IFN-gamma but not and similarly functional IDO expression was only induced by IFN-gamma stimulation . Positive_regulation CD274 TNF 20472834 2301093 Using MDS cell lines and patient samples , we showed that the expression of an immunoinhibitory molecule , [B7-H1] ( CD274 ) , was *induced* by interferon-gamma (IFNgamma) and on MDS blasts . Positive_regulation CD274 TNF 22389764 2566567 Exogenous *restored* [PD-L1] expression on lupus monocytes . Positive_regulation CD274 TNF 24211847 2875904 Blocking studies suggested that *enhanced* [PD-L1] expression and the suppressive activity of the CD8regs generated . Positive_regulation CD276 TLR7 16412017 1513783 While ligation of TLR2 , and TLR9 *led* to detectable changes in ALL [costimulatory molecule] expression , only TLR2 and TLR9 stimulation influenced T-cell responses . Positive_regulation CD276 TLR7 17563917 1763051 ES , but not AWH , inhibited BMDC cytokine and chemokine production and [co-stimulatory molecule] expression ( CD40 , CD86 and MHC class II ) *induced* by ligation . Positive_regulation CD276 TNF 19307991 2052240 This study demonstrates that expression of [B7-H3] on apoptotic cell loading DCs is *up-regulated* markedly by CD40 activation but not by stimulation . Positive_regulation CD28 FAS 19487421 2091216 Naive human T cells triggered by antigen presenting cells expressing a membrane bound form of CD95 ligand (CD95L) or stimulated by anti-CD3 and [-CD28] antibodies in the *presence* of recombinant had reduced activation and proliferation , whereas preactivated , CD95-sensitive T cells underwent apoptosis . Positive_regulation CD28 IL1B 10928971 719641 FK506 inhibited [anti-CD3/CD28] *induced* TNF-alpha and production at concentrations less than 1 ng ml(-1) . Positive_regulation CD28 STK39 9337876 458275 This study therefore demonstrates that ( 1 ) a CD28 activated distinct from both PKC and PI 3-kinase *mediates* ligation stimulated [CD28] phosphorylation , and ( 2 ) the PMA stimulated down-regulation of the coupling of CD28 to PI 3-kinase is not due to PMA stimulated phosphorylation of CD28 . Positive_regulation CD28 TNF 10928971 719640 FK506 inhibited [anti-CD3/CD28] *induced* and IL-1beta production at concentrations less than 1 ng ml(-1) . Positive_regulation CD28 TNF 19299722 2051938 Here , we show that modulation of levels in long-term cultures of human CD8 ( + ) T lymphocytes , by chronic exposure either to a neutralizing Ab or to an inhibitor of the TNF-alpha receptor-1 , increases proliferative potential , *delays* loss of [CD28] expression , retards cytokine profile changes , and enhances telomerase activity . Positive_regulation CD28 TNF 8557665 347526 The c-Jun N-terminal kinases (JNK) are activated by various stimuli , including UV light , interleukin-1 , , and [CD28] *costimulation* . Positive_regulation CD28 TNF 8621542 360043 The Rel family of transcription factors are important mediators of various cytokine stimuli such as interleukin (IL)-1 , , and [CD28] *costimulation* in T cell effector responses . Positive_regulation CD300E TNF 15557162 1340359 moreover , [IREM-2] engagement on monocytes *induced* production . Positive_regulation CD34 ITGB2 17261663 1696752 We measured circulating [CD34] positive mononuclear cells , *activation* of on the surface of neutrophils , and plasma granulocyte-colony stimulating factor levels in 40 patients undergoing coronary stenting . Positive_regulation CD34 TNF 9163602 432083 [CD34+] cell Fas-R expression was *increased* by IFN-gamma and . Positive_regulation CD36 ALOX5 19135147 2031975 This study investigated the *role* of <5-LO> in HNE induced [CD36] expression and macrophage foam cell formation , and the link between HNE and 5-LO . Positive_regulation CD36 ALOX5 19135147 2031978 In peritoneal macrophages from 5-LO-deficient mice , HNE induced CD36 expression was markedly attenuated , confirming a pivotal *role* of <5-LO> in HNE induced [CD36] expression . Positive_regulation CD36 ALOX5 19135147 2031981 Collectively , these data suggest that p38 MAPK mediated activation of <5-LO> by HNE might *enhance* [CD36] expression , consequently leading to the formation of macrophage foam cells . Positive_regulation CD36 EPHB2 22687273 2626497 however , the inhibition of or PKCß downstream of ERK *attenuated* SR-A but not [CD36] expression . Positive_regulation CD36 PECAM1 9529372 496620 The down-regulation of in bEND.3 cells *resulted* in reexpression of endogenous thrombospondin-1 and its antiangiogenic receptor [CD36] . Positive_regulation CD36 RCAN1 24127415 2875058 *regulates* [CD36] expression and its genetic inactivation reduced atherosclerosis extension and severity in Apoe ( -/- ) mice . Positive_regulation CD36 TNF 17335569 1760085 We investigated the *role* of and adalimumab , a human anti-TNFalpha monoclonal antibody widely used in human pathology , in [CD36] expression in human monocytes . Positive_regulation CD36 TNF 20404035 2246080 also *induced* [Cd36] and peroxisome proliferators activated receptor ( Ppar)gamma expression , as well as microsomal triglyceride transfer protein ( Mtp ) protein and mRNA , but suppressed the sterol regulatory element binding protein ( Srebp)1c protein and mRNA level . Positive_regulation CD36 TNF 22492973 2613131 In mid-CL cells , *increased* VEGF mRNA and protein expression ( Western blot analysis ) and reduced [CD36] mRNA levels , while FASL and TNF+IFNG+FASL decreased VEGF protein expression . Positive_regulation CD36 TNF 8619443 353992 The *upregulation* of [CD36] and intercellular adhesion molecule-1 by soluble recombinant ( sr ) <-tumor necrosis factor-alpha> or sr-interferon-gamma did not modify the IRBC interactions with SBECs at the ultrastructural level . Positive_regulation CD38 EPHB2 20570673 2302875 Indeed , [CD38] is enzymatically active in both exosomes and MR , and CD38 ligation *induces* Akt/PKB and activation , which is accompanied by increased translocation of CD38 into MR. In conclusion , the present study indicates that CD38 localizes to MR , where it promotes cell signaling , and it is exported out of the cells through the exosome mediated exocytic pathway , where it may act as an intercellular messenger . Positive_regulation CD38 NT5E 10229870 611246 The reactivity to allogeneic irradiated PBMC was also significantly enhanced by [CD38] stimulation and was *dependent* on expression . Positive_regulation CD38 PECAM1 9494077 490056 [CD38] binding to human myeloid cells is *mediated* by mouse and human . Positive_regulation CD38 TLR7 19685493 2186224 We report that stimulation *induces* expression of [CD38] , a negative prognostic marker , on B-CLL cells . Positive_regulation CD38 TLR7 19685493 2186232 Expression of CD38 is induced by direct stimulation of B-CLL cells through and TLR-9 or [CD38] can be *induced* on B-CLL cells indirectly by a soluble factor induced in non-B-CLL cells after stimulation with TLR-2 , TLR-3 or TLR-5 agonists ; Positive_regulation CD38 TNF 14563702 1199807 Similarly , [CD38] mRNA levels , CD38 expression , and cyclase activity were *increased* by , thus increasing cADPR levels . Positive_regulation CD38 TNF 15266023 1275863 In the present study , we investigated the major signaling pathways by which *induces* [CD38] expression and its role in regulating gene expression in human ASM cells . Positive_regulation CD38 TNF 15266023 1275864 Using flow cytometry analyses , *enhanced* [CD38] expression in a manner that was time- ( 0-24 h ) , concentration- ( 0.1-40 ng/ml ) , and protein synthesis- ( cycloheximide blockade ) dependent . Positive_regulation CD38 TNF 15266023 1275865 Inhibition of the Janus activated kinase/signal transducer and activator of transcription pathways using the soluble inhibitor 2- ( 1,1-dimethylethyl ) -9-fluoro-3,6-dihydro-7H-benz- [ h ] imidaz [ 4,5-f ] isoquinolin-7-one ( DBI ) or with neutralizing antibody against interferon beta (IFNbeta) completely abrogated *induced* [CD38] expression at both protein and mRNA levels . Positive_regulation CD38 TNF 15339743 1323484 First , we observed that *increased* oxytocin induced Ca ( 2+ ) transients and [CD38] expression in human myometrial cells . Positive_regulation CD38 TNF 16291871 1510651 We found that [CD38] expression *induced* by alone was completely abrogated by fluticasone ( 100 nM ) , dexamethasone ( 1 microM ) , or budesonide ( 100 nM ) . Positive_regulation CD38 TNF 16291871 1510652 More importantly , fluticasone failed to induce GRE dependent gene transcription and to suppress *induced* [CD38] expression in ASM cells transfected with constitutively active GRbeta . Positive_regulation CD38 TNF 16333382 1491224 In HASM cells infected with Ad-asCD38 , *induced* , [augmented-CD38] expression and cyclase activity were significantly lower than in TNF-alpha treated cells . Positive_regulation CD38 TNF 16571778 1555990 In human airway smooth muscle ( HASM ) cells , the expression and function of [CD38] are *augmented* by the inflammatory cytokine , leading to increased intracellular calcium response to agonists . Positive_regulation CD38 TNF 16571778 1555991 In HASM cells , *augmented* [CD38] expression and ADP-ribosyl cyclase activity , which were attenuated by dexamethasone . Positive_regulation CD38 TNF 16571778 1555995 An inhibitor of NF-kappaB activation or transfection of cells with IkappaB mutants decreased *induced* [CD38] expression . Positive_regulation CD38 TNF 16571778 1555996 The results indicate that *induced* [CD38] expression involves NF-kappaB expression and its activation and dexamethasone inhibits CD38 expression through NF-kappaB dependent and -independent mechanisms . Positive_regulation CD38 TNF 16705149 1589860 but not RANK-L *led* to the sustained upregulation of both [CD38] and CD157 as demonstrated by real-time PCR and flow cytometry . Positive_regulation CD38 TNF 17164398 1716981 We show that *induced* [CD38] expression negatively affects the expression of osteoclast markers , while it enhances inflammatory gene expression by decreasing ERK1/2 phosphorylation and increasing NF-kappaB activation . Positive_regulation CD38 TNF 17322278 1747582 In human airway smooth muscle ( HASM ) cells , the expression of [CD38] , which synthesizes the calcium mobilizing molecule cyclic ADP-ribose , is *augmented* by , a cytokine implicated in asthma . Positive_regulation CD38 TNF 17322278 1747700 Transfection of HASM cells with a dominant negative MEK decreased while a wild-type ERK increased *induced* [CD38] expression . Positive_regulation CD38 TNF 17322278 1747707 Transfection of a dominant negative c-Jun decreased *induced* [CD38] expression indicating involvement of AP-1 . Positive_regulation CD38 TNF 17322278 1747734 Stability of *induced* [CD38] transcripts were determined in the presence of MAPK inhibitors after arresting the transcription with actinomycin D. Transcript stability decreased in the presence of ERK and p38 MAPK , but not the JNK , inhibitors . Positive_regulation CD38 TNF 18178673 1863031 Results confirmed that significantly *increased* [CD38] expression and ADP-ribosyl cyclase activity , an effect inhibited by CD38 siRNA , but unaltered by CD38 overexpression . Positive_regulation CD38 TNF 18341691 1892138 [CD38] is expressed in human airway smooth muscle ( HASM ) cells , regulates intracellular calcium , and its expression is *augmented* by . Positive_regulation CD38 TNF 18441094 1932698 Dexamethasone also decreased [CD38] expression *induced* by , and part of this effect was attributable to decreased transcript stability . Positive_regulation CD38 TNF 20693316 2351470 Differential *induction* of [CD38] expression by } in asthmatic airway smooth muscle cells . Positive_regulation CD38 TNF 20693316 2351471 *induced* induction of [CD38] expression was greater in ASMA than in ASM cells from nonasthmatic donors ( ASMNA ) . Positive_regulation CD38 TNF 20693316 2351486 The findings suggest that the differential *induction* of [CD38] by in ASMA cells is due to increased transcriptional regulation involving ERK and p38 MAPK activation and is independent of changes in NF-?B or AP-1 activation . Positive_regulation CD38 TNF 22556157 2675432 In human airway smooth muscle ( HASM ) cells , *mediates* [CD38] expression through mitogen activated protein kinases and NF-?B and AP-1 . Positive_regulation CD38 TNF 22556157 2675433 We hypothesized that PI3Ks mediate CD38 expression and are involved in the differential *induction* of [CD38] by in asthmatic HASM cells . Positive_regulation CD38 TNF 22556157 2675446 P110 expression caused Akt activation and basal and *induced* [CD38] expression , whereas PTEN expression attenuated Akt activation and CD38 expression . Positive_regulation CD38 TNF 22556157 2675451 Silencing of p110a or -d , but not p110ß , resulted in comparable attenuation of *induced* [CD38] expression in asthmatic and nonasthmatic cells . Positive_regulation CD38 TNF 22773691 2659876 miR-140-3p regulation of *induced* [CD38] expression in human airway smooth muscle cells . Positive_regulation CD38 TNF 22773691 2659879 In human ASM ( HASM ) cells , *induces* [CD38] expression through activation of MAPKs , NF-?B , and AP-1 , and its expression is differentially elevated in cells from asthmatic patients compared with cells from nonasthmatic subjects . Positive_regulation CD3D JAG1 8757315 377711 CD4 participation in TCR/CD3 associated activation through interaction with the MHC class II *results* in formation of a [CD4-TCR/CD3] complex capable of maximal signal transduction . Positive_regulation CD3D TNF 7678624 209959 CD5/CD28 ligation induced production of , but not of IL-4 , and did not *induce* modulation of the [TCR/CD3] complex . Positive_regulation CD3E JAG1 8757315 377712 CD4 participation in TCR/CD3 associated activation through interaction with the MHC class II *results* in formation of a [CD4-TCR/CD3] complex capable of maximal signal transduction . Positive_regulation CD3E TNF 7678624 209963 CD5/CD28 ligation induced production of , but not of IL-4 , and did not *induce* modulation of the [TCR/CD3] complex . Positive_regulation CD3G JAG1 8757315 377713 CD4 participation in TCR/CD3 associated activation through interaction with the MHC class II *results* in formation of a [CD4-TCR/CD3] complex capable of maximal signal transduction . Positive_regulation CD3G TNF 7678624 209967 CD5/CD28 ligation induced production of , but not of IL-4 , and did not *induce* modulation of the [TCR/CD3] complex . Positive_regulation CD4 CD14 17974479 1831114 Additionally , GMA depleted proinflammatory ( + ) CD16 ( + ) monocytes and was *followed* by an increase in [CD4] ( + ) T lymphocytes including the regulatory CD4 ( + ) CD25 ( high+ ) Foxp3 phenotype . Positive_regulation CD4 CD14 19200602 2049767 Moreover , ( + ) monocytes *promote* NKG2D ( + ) [CD4] ( + ) T cells activation through the NKG2D-MIC engagement in the pathogenesis of SLE . Positive_regulation CD4 CD14 20921523 2337556 We demonstrate here that the HO-1 inhibitor tin mesoporphyrin ( SnMP ) induces *activation* , proliferation , and maturation of naive [CD4] ( + ) and CD8 ( + ) T cells via interactions with ( + ) monocytes in vitro . Positive_regulation CD4 CD14 24383466 2911959 Decidual ( + ) DC-SIGN ( + ) antigen presenting cells (APCs) *enhance* the HLA-G expression of cocultured [CD4] ( + ) naïve T cells in vitro . Positive_regulation CD4 CD14 24866794 2945615 Collectively , these data identify a previously unrecognized *role* for in regulating macrophage plasticity and [CD4] ( + ) T cell biasing during helminth infection . Positive_regulation CD4 FAS 10393955 627321 In vivo experiments in hen egg lysozyme (HEL) T cell receptor transgenic mice show that CD4 ( + ) T cells from HEL-naïve mice are killed by Fas ligation , but [CD4] ( + ) T cells from long-term HEL exposed mice are *costimulated* by ligation . Positive_regulation CD4 FAS 10601365 574604 Recent studies have demonstrated that engagement of TCR and *induces* naive [CD4] ( + ) T cells to undergo apoptosis , and the same treatment enhances the proliferation of memory CD4 ( + ) T cells . Positive_regulation CD4 FAS 11509617 848602 Thus , perforin and were not *involved* in [CD4] ( + ) and CD8 ( + ) T cell mediated restriction of MTB growth . Positive_regulation CD4 FAS 12921948 1131034 Expression of ( Apo-1/Fas ) and CD45RO on monocytes increased significantly on the 5th day , and [CD4] expression on monocytes *increased* significantly on the 14th day . Positive_regulation CD4 FAS 15709041 1373278 Finally , we found that interleukin 7 (IL-7) increases *mediated* [CD4] ( + ) and CD8 ( + ) T-cell death induced by HIV-1 ( LAI ) . Positive_regulation CD4 FAS 17045460 1641813 Not only absence of MHC-I and upregulation , but also resistance to cytokine induced killing of beta-cells and a complete lack of CXCL-10 ( IP10 ) production in islets *led* to a lack of islet infiltration and impaired activation of autoaggressive [CD4] ( + ) and CD8 ( + ) T-cells in these mice . Positive_regulation CD4 FAS 21469125 2422745 We found that [CD4] ( + ) T lymphocytes *require* expression in the recipients ' target cells to induce diabetes . Positive_regulation CD4 FAS 21839428 2490547 Loss of both Bim and also *increased* the number of virus-specific [CD4] ( + ) T cells found in the lymph nodes compared to the parental genotypes or wildtype mice . Positive_regulation CD4 FAS 22994871 2694180 This research has revealed an alternative mechanism in asthma that involves low doses of IFN-? , which attenuate airway inflammation through enhancing *induced* [CD4] ( + ) T cell apoptosis . Positive_regulation CD4 FAS 8652808 366547 [CD4+] and CD8+ T-cell apoptosis *induced* by ligation was enhanced by inhibitors of protein synthesis and was prevented either by a soluble Fas receptor decoy or an antagonistic anti-Fas antibody . Positive_regulation CD4 FAS 8855300 388204 ( CD95 ) expression and death mediating function are *induced* by [CD4] cross linking on CD4+ T cells . Positive_regulation CD4 FAS 8924258 371606 To analyse the *role* of the apoptosis inducing receptor in the depletion of [CD4+] and CD8+ T cells in HIV infected individuals . Positive_regulation CD4 IL1B 19161420 2007011 IL-23 , IL-6 , transforming growth factor ( TGF-beta1 ) , and in supernatants from activated human DCs *induce* human naive [CD4] ( + ) T cells to produce IL-17 . Positive_regulation CD4 IL1B 19359475 2074542 These results indicate that signaling in T cells markedly *induces* robust and durable primary and secondary [CD4] responses . Positive_regulation CD4 IL6R 16540526 1537056 Differential expression of and CD130 *mediates* different STAT-3 phosphorylation in [CD4+CD25-] and CD25high regulatory T cells . Positive_regulation CD4 ITGAL 15383575 1298952 We find that in addition to its role in trafficking to peripheral lymph nodes , is *required* for optimal [CD4] ( + ) T cell priming in vivo upon s.c . Positive_regulation CD4 ITGAL 15383575 1298953 Taken together , these results demonstrate that is *required* for optimal [CD4] ( + ) T cell priming in vivo . Positive_regulation CD4 ITGAL 15778396 1385098 These results indicate a prominent *role* for HLA-DP and in BAL [CD4] ( + ) T cell activation and further suggest that specific Abs to these molecules could serve as a possible therapy for chronic beryllium disease . Positive_regulation CD4 ITGAL 17277114 1697808 We also find that in addition to its role in trafficking to intestinal secondary lymphoid organs , is *required* for optimal [CD4] ( + ) T cell proliferation in vivo upon oral Ag immunization . Positive_regulation CD4 ITGAL 22488891 2696789 Taken together , our data suggest that is not *required* for EAg induced activation of [CD4] ( + ) T cells in vitro or in vivo but is required for trafficking of T cells to the MLNs and homing of colitogenic effector cells to the colon where they initiate chronic gut inflammation . Positive_regulation CD4 ITGB2 15383575 1298950 We examined the *role* of in [CD4] ( + ) T cell activation in vivo by using a system that allows for segregation of the migration and activation defects through the adoptive transfer of LFA-1-deficient ( CD18 ( -/- ) ) CD4 ( + ) T cells from DO11.10 Ag-specific TCR transgenic mice into wild-type BALB/c mice . Positive_regulation CD4 JAG1 21918192 2491973 tumor rejection requires IL-17 , which is produced by IFN-?-deficient [CD4] ( + ) T cells in *response* to tumor ( TAs ) . Positive_regulation CD4 JAG1 23319735 2738324 Finally , IVE-TB *induced* strong IFN-? ( + ) /TNF-a ( + ) CD8 ( + ) and TNF-a ( + ) /IL-2 ( + ) CD154 ( + ) [/CD4] ( + ) T cell responses in PBMC from long-term latently M. tuberculosis infected individuals . Positive_regulation CD4 JAG1 8757315 377714 CD4 participation in TCR/CD3 associated activation through interaction with the MHC class II *results* in formation of a [CD4-TCR/CD3] complex capable of maximal signal transduction . Positive_regulation CD4 MMP28 20639459 2418899 Intracellular calcium flux was augmented in *response* to inhibition or deficiency in the same cells , and IL-2 production was reduced in [CD4] ( + ) and CD8 ( + ) MMP9 ( -/- ) T cells . Positive_regulation CD4 MMP7 20639459 2418914 Intracellular calcium flux was augmented in *response* to inhibition or deficiency in the same cells , and IL-2 production was reduced in [CD4] ( + ) and CD8 ( + ) MMP9 ( -/- ) T cells . Positive_regulation CD4 MUC16 19782714 2183810 Interestingly , CA-125-specific T-cell activation could not be further improved by Treg depletion in vitro , as *induced* a suppressive [CD4] ( + ) CD25 ( + ) FoxP3 ( + ) CD127 ( - ) T cell subset derived from the originally Treg depleted T-cell fraction . Positive_regulation CD4 SELL 12355444 993710 Here , we demonstrate that surface expression of *enhances* [CD4] ( + ) T cell activation in vitro . Positive_regulation CD4 STAT4 10209051 607353 Both lineages require signal transducer and activator of transcription ( Stat ) 4 activation for IFN-gamma induced by interleukin (IL)-12/IL-18 signaling , but only [CD4] ( + ) T cells *require* for IFN-gamma induction via the TCR pathway . Positive_regulation CD4 STAT4 10209051 607358 In response to antigen , CD8 ( + ) T cells can produce IFN-gamma independently of IL-12 , whereas [CD4] ( + ) T cells *require* IL-12 and activation . Positive_regulation CD4 TCN1 17114496 1651689 mediated responses markedly *enhanced* the appearance and local accumulation of highly differentiated ( CD44 ( high ) ) [CD4] and CD8 endogenous tumor infiltrating T cells when compared with that of untreated tumor bearing mice . Positive_regulation CD4 TCN1 21092462 2350038 to study the change of airway inflammation *induced* by and the expression of [CD4] ( + ) CD25 ( + ) regulatory T cells ( Treg ) in smoking cessation rats . Positive_regulation CD4 TF 1569393 187085 Results show that both [CD4+] and CD8+ T clones can process and present HBenvAg to class II-restricted cytotoxic T lymphocytes and that the CD71 is *involved* in efficient HBenvAg uptake by T cells . Positive_regulation CD4 TLR7 15128790 1245255 APC engagement indirectly *enhances* activated [CD4] ( + ) T cell proliferation , differentiation , and survival by promoting the up-regulation of costimulatory molecules and the secretion of proinflammatory cytokines . Positive_regulation CD4 TLR7 17202339 1680922 Together , these findings support a model of CD8 ( + ) T cell memory cell differentiation involving the delivery of key signals early in the priming process based on chemokine guided attraction of naive CD8 ( + ) T cells to sites of Ag-driven interactions between *activated* dendritic cells and [CD4] ( + ) T cells . Positive_regulation CD4 TLR7 19218890 2039577 Mucosal inflammation and [CD4] cell *activation* as well as disruption of function and epithelial integrity represent potential causes for such effect . Positive_regulation CD4 TNF 10877490 708905 However , while has a protective role in antiviral resistance of activated CD4+ T cells to R5-tropic viruses , it *enhances* CXCR4 expression of [CD4+] T cells and mediates increased susceptibility to infection with X4-tropic strains of HIV and recombinant SIVs . Positive_regulation CD4 TNF 11401990 824759 In a coculture system , CT-treated [CD4] ( + ) T cells *induced* significantly less and IL-12 p70 production by both autologous monocytes and monocyte derived dendritic cells than either LT-IIa- or LT-IIb treated CD4 ( + ) T cells . Positive_regulation CD4 TNF 11574756 864956 Theophylline inhibits *induced* [CD4] expression on human eosinophils and CD4+ eosinophil migration . Positive_regulation CD4 TNF 11744830 888828 Results showed that M-stimulated production of interleukin (IL)-10 and *increases* in [CD4] ( + ) and CD8 ( + ) cells of African infected patients and uninfected study subject ; Positive_regulation CD4 TNF 12734353 1087318 These findings indicate that *promotes* [CD4] ( + ) T cell alloproliferation , IFN-gamma responses , and intestinal GVHD by IL-12 independent mechanisms . Positive_regulation CD4 TNF 15383572 1298948 *increased* surface membrane [CD4] ( + ) expression by 6-fold as previously described , and increased IL-16 induced cell migration by 2.2-fold . Positive_regulation CD4 TNF 15749890 1379728 In the absence of WSX-1 , an increased production of the proinflammatory cytokines and IL-12p40 *resulted* in elevated [CD4+] T cell activation and IFN-gamma production , which enhanced macrophage effector functions and reduced bacterial loads . Positive_regulation CD4 TNF 1628901 191843 We observed that CD4 antigen expression on ML3 cells is almost undetectable and that and IFN-gamma *induced* [CD4] antigen expression on these cells . Positive_regulation CD4 TNF 17538882 1746893 Glucocorticoid induced receptor family related protein triggering *enhances* HIV-specific [CD4+] T cell cytokine secretion and protects HIV-specific CD4+ T cells from apoptosis . Positive_regulation CD4 TNF 17644042 1780299 Furthermore IL-15 stimulated CD57 ( + ) CD28 ( - ) [CD4] ( + ) T cells *induced* production from monocytes . Positive_regulation CD4 TNF 1921451 168513 *induced* expression of [CD4] and CD71 , increased the intensity of HLA-DR , CD25 , CD11c and CD13 expression and decreased both the intensity and frequency of sIg and cIg positivity . Positive_regulation CD4 TNF 1921451 168517 alpha-IFN decreased CD25 expression , the tartrate-resistant acid phosphatase activity ( TRAP ) , reduced the *induced* [CD4] and CD71 expression and antagonized the TNF effect on the Ig expression . Positive_regulation CD4 TNF 19568710 2104589 The level of CD3 ( + ) , [CD4] ( + ) , the ratio of CD4 and CD8 ( + ) , IgA , IgM , IgG and IL-2 decreased in patients with NSCLC on day 1 after operation , and the level of CD8 and *increased* compared to pre-operation . Positive_regulation CD4 TNF 21641234 2459346 It indicates that *reduces* the number and frequency of regulatory [CD4] ( + ) Foxp3 ( + ) T cells in children with diabetes type 1 and that in vitro treatment with anti-TNF antibody seems to rescue this cell subset from its defective effects . Positive_regulation CD4 TNF 23664593 2838377 In vitro , the isolated human [CD4] ( + ) T cells were *stimulated* by or IFN-? . Positive_regulation CD4 TNF 24383743 2932650 However , we and others showed that interaction was *critical* for the activation and expansion of functional [CD4] ( + ) Foxp3 ( + ) regulatory T ( Treg ) cells . Positive_regulation CD4 TNF 7517419 261720 When TNF-alpha was immobilized on FN , less was *required* to induce [CD4+] cell binding to FN. Soluble , and to a greater extent FN-bound , TNF-alpha synergizes with PMA to intensify protein tyrosine phosphorylation in FN-bound CD4+ cells , and this effect of TNF-alpha was inhibited by inhibitors of tyrosine kinase . Positive_regulation CD4 TNF 8690465 372639 Our data indicate that *induced* [CD4] expression on human eosinophils is dependent on protein synthesis and may be dependent on tyrosine kinase activity . Positive_regulation CD4 TNF 9269777 450114 [CD4] cross linking ( CD4XL ) *induces* RAS activation and secretion in CD4+ T cells . Positive_regulation CD4 TNF 9698257 524878 IL-1-alpha and differentially *regulate* [CD4] and Mac-1 expression in mouse microglia . Positive_regulation CD4 TNF 9698257 524886 The addition of IL-1alpha , but not , also *led* to an increase in [CD4] expression on plate supported microglia with a similar dose response and time course . Positive_regulation CD4 TNFSF10 10706675 673222 ( Apo2 ligand ) and TWEAK ( Apo3 ligand ) *mediate* [CD4+] T cell killing of antigen presenting macrophages . Positive_regulation CD4 TNFSF10 14872508 1208503 engagement selectively *activated* human [CD4] , rather than CD8 , T cells and augmented IFNgamma production . Positive_regulation CD4 TNFSF10 15990565 1429558 The increase in death receptor expression and acquisition of TRAIL sensitivity *requires* the chemokine coreceptor CXCR4 but not CCR5 or the [CD4] receptor . Positive_regulation CD40 ALOX5 21200133 2391674 We describe an alternative ROS production pathway that is triggered by [CD40] ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 MAPK . Positive_regulation CD40 CCL17 11981828 938312 [CD40] ligation of PB cells *induced* the mRNA expression of both CCL22 and . Positive_regulation CD40 CD14 9715264 527768 Thus , IL-4 or [CD40] ligation *induced* CD1a+CD14- and DC precursors to differentiate into phenotypically close but functionally different DC populations , suggesting that DC function is primarily determined by their origin . Positive_regulation CD40 CD22 16393971 1505964 By contrast , anti-CD40 stimulation specifically up-regulated anti-IgM induced phosphorylation of tyrosines within two ITIM motifs , Y762 and Y842 , which was consistent with in vivo finding of the negative *role* of in [CD40] signaling . Positive_regulation CD40 CHI3L1 7594496 334776 *Stimulation* of [CD40] with purified soluble induces proinflammatory responses in human monocytes . Positive_regulation CD40 EPHB2 18481208 1840564 The differential requirement for ROS in the *activation* of , JNK , p38 , and Akt by the BCR , [CD40] , and CXCR4 likely reflects the multiplicity of upstream activators for each of these kinases , only some of which may be regulated in a redox dependent manner . Positive_regulation CD40 F2R 17392495 1716256 In contrast to the effect of adenosine diphosphate , ex vivo stimulation with activating peptide ( TRAP ) *increased* [CD40] and CD40L expression in both groups . Positive_regulation CD40 FAS 10756053 682850 A model is proposed to explain how both a specific immune response and immunosuppression can simultaneously occur after MV infection through *mediated* apoptosis and [CD40] activation of DCs . Positive_regulation CD40 FAS 18469093 1938950 [CD40] engagement of Th40 cells *induces* expression but further confers resistance to Fas mediated cell death in NOD mice . Positive_regulation CD40 FAS 7595225 330470 [CD40] ligation *induces* expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway . Positive_regulation CD40 IL1B 8647193 366267 However , [CD40] was rapidly up-regulated by culture , and its expression was further *enhanced* by interleukin (IL)-1 alpha , , IL-3 , tumor necrosis factor-alpha and granulocyte/macrophage-colony stimulating factor . Positive_regulation CD40 IL1B 8648174 363693 Taken together , our present results suggest that is *required* for the upregulation of Ia , ICAM-1 , B7-2 , and [CD40] , while GM-CSF is required for the upregulation of B7-1 and B7-2 , although it still remains unclear why the injected GM-CSF could not augment B7-1 expression on Langerhans cells in vivo and why anti-IL-1 beta Ab did not suppress the upregulation of Ia , ICAM-1 , or CD40 on cultured Langerhans cells . Positive_regulation CD40 IL1B 9757011 535903 Moreover , and IFN-gamma synergistically *increased* the Abeta induced expression of [CD40] and IFN-gammaR . Positive_regulation CD40 IL1B 9831176 551460 increased both MCP-1 and IL-8 release , and *increased* the expression of ICAM-1 and [CD40] , but not HLA class II molecules . Positive_regulation CD40 ITGB2 14510698 1146410 Targeting both *mediated* signals and [CD40/CD40L] costimulation resulted in synergistic effects , such that hepatocellular survival > 60 days was achieved in 100 % of C57BL/6 mice ( which have both CD4- and CD8 dependent T-cell pathways available ) . Positive_regulation CD40 LBP 19265128 2045463 *up-regulated* DC expression of [CD40] , CD80 , CD86 , and MHC class II molecules ; Positive_regulation CD40 TLR7 22685319 2675999 Interestingly , despite expression of TLR mRNA on Kupffer cells , ligation of TLR4 , , and TLR9 *resulted* in a weak induction of IL-10 , low or undetectable levels of IL-12p40 and TNF , and up-regulation of [CD40] on the surface . Positive_regulation CD40 TNF 10096561 601441 [CD40] expression could be enhanced in CD40 positive MM by *stimulation* with IFN-gamma and but not by interleukin (IL)-1beta or CD40 triggering . Positive_regulation CD40 TNF 10332965 614909 IL-10 exerted inhibitory effects on both CD40 ligation induced and [CD40] ligation plus IFN-gamma *induced* production by ST cells . Positive_regulation CD40 TNF 10449168 637222 *enhanced* [CD40] expression on LC during culture . Positive_regulation CD40 TNF 11238627 790805 SB203580 , an inhibitor of the p38 MAPK , but not the extracellular signal regulated kinase l/2 pathway blocker PD98059 , inhibited the up-regulation of CD1a , [CD40] , CD80 , CD86 , HLA-DR , and the DC maturation marker CD83 *induced* by LPS and . Positive_regulation CD40 TNF 11488834 845256 In this manuscript , we report that human dermal microvascular endothelial cells ( HDMEC ) express cell surface [CD40] and that the expression of CD40 is *increased* by the proinflammatory cytokines and interferon (IFN)-gamma . Positive_regulation CD40 TNF 11818376 908172 In contrast , *enhanced* [CD40] on HCE but not on HCS cells . Positive_regulation CD40 TNF 11830590 928975 Critical *role* of and NF-kappa B in interferon-gamma -induced [CD40] expression in microglia/macrophages . Positive_regulation CD40 TNF 12067408 955022 CD34 expression was gradually lost , so that by day 9 , the majority of the cells were CD34 ( - ) /CMRF-44 ( + ) . GM-CSF and also *induced* [CD40] expression , and up-regulation of CD54 and MHC class II on CD34 ( + ) cells ; Positive_regulation CD40 TNF 12234299 988837 *up-regulated* C3 , [CD40] and B7h production by PTEC . Positive_regulation CD40 TNF 12426205 1014331 Reverse transcription-polymerase chain reaction and Western blot analysis revealed that treatment of either cell type with atorvastatin , cerivastatin , or pravastatin ( 1 to 10 micromol/L ) inhibited interferon-gamma plus *stimulated* [CD40] expression by approximately 50 % , an effect that was not reversed by the HMG-CoA reductase product mevalonic acid ( 400 micromol/L ) . Positive_regulation CD40 TNF 12930919 1164044 On the contrary , neutralizing significantly *increased* the IGF-I induced up-regulation of CD83 and [CD40] . Positive_regulation CD40 TNF 1378865 192689 IL-1 alpha , , IFN-gamma , but not IL-4 , significantly *up-regulated* the membrane expression of [CD40] on cultured TEC . Positive_regulation CD40 TNF 14511233 1146558 Both NAC and GSH completely abolished the *induced* enhancement of [CD40] expression , but had no considerable effect on the expression of CD80 , CD86 and MHC . Positive_regulation CD40 TNF 14511233 1146559 The inhibitory effect of NAC or GSH on *induced* [CD40] expression was released by simply removing these agents from the culture . Positive_regulation CD40 TNF 14729358 1198388 In the primary cultured cells , *induced* an important upregulation of ICAM-1 , Fas and [CD40] whereas CD44 and CD63 were significantly decreased . Positive_regulation CD40 TNF 15240722 1270433 The production of TNF and IL-1beta was induced by membranes of stimulated T cells in the three types of target cells , whereas [CD40LT] *induced* production in IFN-gamma-macrophages only . Positive_regulation CD40 TNF 15696085 1372139 *increased* expression of both [CD40] and OX40 ligand on both asthmatic and nonasthmatic airway smooth muscle cells . Positive_regulation CD40 TNF 15696085 1372143 IL-1beta alone had no effect , but it attenuated the *induced* expression of both [CD40] and OX40 ligand . Positive_regulation CD40 TNF 15921025 1413661 Nifedipine completely inhibited *induced* upregulation of [CD40] mRNA levels in HUVEC . Positive_regulation CD40 TNF 16025512 1435666 These in vitro studies demonstrated that *induces* [CD40] expression in hepatocytes and that subsequent activation of CD40 results in hepatocyte apoptosis mediated at least in part by enhanced hepatocyte expression of FasL . Positive_regulation CD40 TNF 16456024 1522388 In vitro infliximab prevented *induced* [CD40] and VCAM-1 expression by HIMEC , and reduced PBT , but not platelet , surface CD40L expression and sCD40L release . Positive_regulation CD40 TNF 16495528 1528770 In addition , [CD40] stimulation *required* the presence of receptor 2 to reduce parasite load in vivo . Positive_regulation CD40 TNF 16552709 1542089 significantly *induced* B7-H2 and [CD40] expression by A549 cells , but had no effect on B7-1 or B7-2 expression . Positive_regulation CD40 TNF 17062332 1637192 Fenofibrate inhibits *induced* expression of [CD40] and matrix metalloproteinase in human vascular endothelial cells . Positive_regulation CD40 TNF 17062332 1637215 To investigate the regulatory effects of fenofibrate on *induced* [CD40] expression and matrix metalloproteinase (MMP) activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation CD40 TNF 17062332 1637239 Quantitative RT-PCR and flow cytometry were employed to evaluate the effect of fenofibrate on *induced* CD40 mRNA and cell surface [CD40] expression in HUVECs , and gelatin zymography was used to determine the effect of fenofibrate on the gelatinolytic activities of MMP-2 and MMP-9 in TNF-alpha stimulated HUVECs . Positive_regulation CD40 TNF 17202332 1680902 Guanosine effects were mediated by an increased phosphorylation of Akt , a PI3K downstream effector , as well as of ERK1/2 and p38 in the MAPK system , because culture pretreatment with selective ERK1/2 , p38 MAPK , and PI3K antagonists ( U0126 , SB203580 , or LY294002 , respectively ) counteracted guanosine inhibition on *induced* [CD40] expression and function as well as on STAT-1alpha or NF-kappaB nuclear translocation . Positive_regulation CD40 TNF 17507688 1772754 IFN-gamma induced [CD40] expression *involves* activation of STAT-1alpha as well as NF-kappaB activation through an autocrine response to IFN-gamma induced production . Positive_regulation CD40 TNF 18303186 1873575 While recombinant human *augmented* CD54 and [CD40] expression in a dose dependent manner , rhTNF-alpha did not increase CD86 expression . Positive_regulation CD40 TNF 19220210 2105892 Interferon-gamma and synergistically *increased* [CD40] expression to a greater extent on asthmatic than on nonasthmatic ASM . Positive_regulation CD40 TNF 19220210 2105897 and IFN-gamma *induced* [CD40] via nuclear factor-kappaB (NF-kappaB) and signal transducer and activator of transcription-3 in both cell types and modulated OX40L via NF-kappaB and c-Jun N terminal kinase in nonasthmatic cells . Positive_regulation CD40 TNF 20006573 2199864 *regulates* [CD40] expression through SMAR1 phosphorylation . Positive_regulation CD40 TNF 21367977 2420681 CD40 and CD40L were minimally expressed on CD34 ( + ) , CD34 ( - ) /CD33 ( + ) , and CD34 ( - ) /CD33 ( - ) /CD15 ( + ) cells , but [CD40] was substantially induced in the *presence* of . Positive_regulation CD40 TNF 22010829 2539713 These results reveal an important *role* of induction in [CD40] 's chemosensitization activity and suggest that modulating TNF-a autocrine from cancer cells is an effective option for increasing the anticancer value of chemotherapeutics such as cisplatin . Positive_regulation CD40 TNF 22717288 2676080 SIRT1 regulates *induced* expression of [CD40] in 3T3-L1 adipocytes via NF-?B pathway . Positive_regulation CD40 TNF 22717288 2676084 Overexpression of SIRT1 or SIRT1 activation by resveratrol obviously attenuated the expression of [CD40] *induced* by in 3T3-L1 adipocytes , whereas knockdown of SIRT1 or SIRT1 inhibition by nicotinamide and sirtinol significantly enhanced TNF-a induced expression of CD40 . Positive_regulation CD40 TNF 22717288 2676086 The combination treatment of resveratrol and PDTC significantly reduced *induced* expression of [CD40] , and the inhibitory effects were higher than that of the single treatment . Positive_regulation CD40 TNF 22717288 2676087 Taken together , SIRT1 exerts anti-inflammatory property by regulating *induced* expression of [CD40] partially through the NF-?B pathway in 3T3-L1 adipocytes . Positive_regulation CD40 TNF 23072727 2716897 Our study indicates that sleep-wake dysregulation in autoimmune diseases may result from [CD40] *induced* : TNFR1 mediated alterations of molecular pathways , which regulate sleep-wake behavior . Positive_regulation CD40 TNF 23075766 2710528 SIRT1 regulates [CD40] expression *induced* by via NF-?B pathway in endothelial cells . Positive_regulation CD40 TNF 23075766 2710531 The present study was thus designed to explore the potential effect of SIRT1 on [CD40] expression *induced* by and to disclose the underlying mechanism in CRL-1730 endothelial cells . Positive_regulation CD40 TNF 23075766 2710535 Pretreatment with resveratrol ( a potent SIRT1 activator ) inhibited *induced* [CD40] expression , while pretreatment with nicotinamide ( class b HDACs inhibitor nicotinamide ) or sirtinol ( a known SIRT1 inhibitor ) , especially SIRT1 siRNA significantly augmented TNF-a induced CD40 expression . Positive_regulation CD40 TNF 23075766 2710536 The frther sudy idicated that PDTC ( NF-?B inhibitor ) pretreatment attenuated *induced* [CD40] expression , and SIRT1 siRNA significantly augmented TNF-a induced acetylated-NF-?B p65 ( Lys310 ) expression . Positive_regulation CD40 TNF 23075766 2710540 The present study provides the direct evidence that SIRT1 can inhibit *induced* [CD40] expression in CRL-1730 endothelial cells by deacetylating the RelA/p65 subunit of NF-?B at lysine 310 , which provides new insights into understanding of the anti-inflammatory and anti-athroscerotic actions of SIRT1 . Positive_regulation CD40 TNF 23603572 2784043 PPARa agonist fenofibrate attenuates *induced* [CD40] expression in 3T3-L1 adipocytes via the SIRT1 dependent signaling pathway . Positive_regulation CD40 TNF 23918687 2840600 Here we found that adipocyte stimulation with CD40L increased the expression of CD40 , as well as of chemokines , such as MCP-1 , CCL4 , or CCL5 , whereas adipocyte [CD40] expression was also *stimulated* by but not palmitate . Positive_regulation CD40 TNF 24022598 2916095 The protective effect of fenofibrate against *induced* [CD40] expression through SIRT1 mediated deacetylation of NF-?B in endothelial cells . Positive_regulation CD40 TNF 24022598 2916097 These results indicate that fenofibrate has protective effect against *induced* [CD40] expression through SIRT1 mediated deacetylation of the p65 subunit of NF-?B . Positive_regulation CD40 TNF 7621870 315629 Furthermore , IL-10 led to the down-regulation of various surface antigens , especially of CD86 and CD54 , whereas and TRAP *enhanced* the expression of MHC class I and II antigens and of the accessory molecules [CD40] , CD54 , CD80 and CD86 . Positive_regulation CD40 TNF 8647193 366265 However , [CD40] was rapidly up-regulated by culture , and its expression was further *enhanced* by interleukin (IL)-1 alpha , IL-1 beta , IL-3 , and granulocyte/macrophage-colony stimulating factor . Positive_regulation CD40 TNF 8980186 403719 Expression of [CD40] protein was *increased* in 2 of 3 cell lines with constitutive CD40 expression by interferon-gamma but not by granulocyte/macrophage colony stimulating factor , interleukin-2 or . Positive_regulation CD40 TNF 9205097 440477 Epstein-Barr virus encoded LMP1 and [CD40] mediate IL-6 production in epithelial cells via an NF-kappaB pathway *involving* receptor associated factors . Positive_regulation CD40 TP63 24709684 2931780 Therapeutic application of [anti-CD40] prevented full *activation* of CD4 positive T cells that were in the process of priming and suppressed production of interferon-? in peripheral lymph nodes , spleen , and serum , and of interleukin-6 , , intercellular adhesion molecule-1 , and vascular cell adhesion molecule-1 , which are associated with activation of the nuclear factor-?B signaling pathway . Positive_regulation CD40LG CCL17 23686488 2796685 We found that IL-4 and [CD40L] are expressed by intratumoral TFH and *induce* production of and CCL22 by FL tumor cells . Positive_regulation CD40LG CHI3L1 7535471 287818 Upregulation ( by IL-4 ) of CD40 on B-cells which then may be *stimulated* by ( [CD40 ligand] ) can constitute an early and important event in the IgE mediated allergic reaction . Positive_regulation CD40LG EPHB2 22142890 2568509 Decreased activation also *resulted* in overexpression and demethylation of the X-linked methylation-sensitive gene [CD40lg] in female but not male mice , consistent with demethylation of the second X chromosome in the females . Positive_regulation CD40LG EPHB2 23576011 2804321 Decreasing signaling and methyl donors also *caused* demethylation and overexpression of the [CD40lg] gene in female mice , consistent with demethylation of the second X chromosome . Positive_regulation CD40LG F2R 17392495 1716257 In contrast to the effect of adenosine diphosphate , ex vivo stimulation with activating peptide ( TRAP ) *increased* CD40 and [CD40L] expression in both groups . Positive_regulation CD40LG FAS 8871610 389539 It has been shown that [CD40L] can *induce* both expression and susceptibility to Fas mediated killing in B cells , while anti-Ig can partially rescue B cells from Fas mediated killing . Positive_regulation CD40LG FAS 9045916 416672 While expression could be *induced* in B-1 cells to a comparable level as that in B-2 cells by cross linking [CD40L-CD8alpha] with an anti-CD8alpha antibody , the sensitivity to Fas mediated apoptosis in B-1 cells was significantly reduced compared with B2 cells . Positive_regulation CD40LG FAS 9221764 442627 Studies with human B cells show that the binding of [CD154] ( gp39 , CD40L ) to CD40 recruits TNF receptor- associated factor 2 ( TRAF2 ) and TRAF3 to the receptor complex , induces the downregulation of the nonreceptor associated TRAFs in the cell and *induces* an increased expression of on the cell surface . Positive_regulation CD40LG ITGB2 14510698 1146411 Targeting both mediated signals and [CD40/CD40L] *costimulation* resulted in synergistic effects , such that hepatocellular survival > 60 days was achieved in 100 % of C57BL/6 mice ( which have both CD4- and CD8 dependent T-cell pathways available ) . Positive_regulation CD40LG ITGB2 18675355 1984579 While [anti-CD40L] did not impair T cell proliferation , *reduced* both CD4 and CD8 T cell proliferation , and combining anti-LFA-1 with everolimus or DSG had an additive inhibitory effect on CD4 T cell proliferation . Positive_regulation CD40LG JAG1 10395655 627478 In vivo Ig responses to soluble , haptenated polysaccharide ( PS ) are T cell independent and do not *require* [CD40 ligand (CD40L)] . Positive_regulation CD40LG JAG1 23319735 2738323 Finally , IVE-TB *induced* strong IFN-? ( + ) /TNF-a ( + ) CD8 ( + ) and TNF-a ( + ) /IL-2 ( + ) [CD154] ( + ) /CD4 ( + ) T cell responses in PBMC from long-term latently M. tuberculosis infected individuals . Positive_regulation CD40LG JAG1 9200457 439608 Whereas the response to splenic APC expressing Mls(a) *requires* [CD40L] expression , the response to alloantigen bearing APC does not . Positive_regulation CD40LG MMP28 22349180 2586733 The inhibitor *reduced* sepsis induced release of [CD40L] and maintained normal levels of CD40L on platelets . Positive_regulation CD40LG MMP7 22349180 2586748 The inhibitor *reduced* sepsis induced release of [CD40L] and maintained normal levels of CD40L on platelets . Positive_regulation CD40LG TNF 12207328 983561 Human lung myofibroblasts as effectors of the inflammatory process : the common receptor gamma chain is induced by Th2 cytokines , and [CD40 ligand] is *induced* by lipopolysaccharide , thrombin and . Positive_regulation CD40LG TNF 12689942 1106075 cDNA microarray studies using the CNIO OncoChip of 29 MF and 11 ID cases revealed a signature of 27 genes implicated in the tumorigenesis of MF , including *dependent* apoptosis regulators , STAT4 , [CD40L] , and other oncogenes and apoptosis inhibitors . Positive_regulation CD40LG TNF 12754109 1090426 Relative and competitive RT-PCR analysis verified downregulation of *mediated* expression of [CD40L] and IL-8 by Dexa and Dexa-Ab ( hEsel ) , respectively . Positive_regulation CD40LG TNF 15231570 1321997 [CD40L] stimulation *induced* significant secretion of and interleukin 12 (IL-12) p70 from both HIV-1 exposed and unexposed DCs . Positive_regulation CD40LG TNF 17031267 1630702 *stimulated* the expression of both [CD40L] and PECAM in cultured BAEC . Positive_regulation CD40LG TNF 19821118 2176069 Among these cytokines , *up-regulated* [TRAP] expression in the RAW 264.7 monocyte/macrophage cell line . Positive_regulation CD40LG TNF 7510740 249998 In addition to proliferation , [CD40L] *induces* lectin mediated cytolytic activity in thymic gamma delta T cells as well as the production of IFN-gamma and . Positive_regulation CD44 ANGPT1 19916173 2166596 Transfection of into human gastric cancer cell line BGC-823 can significantly *increase* expression of integrin beta1 and [CD44V6] , by which cell adhesion and metastasis to the ECM are promoted . Positive_regulation CD44 EPHB2 21283538 2387782 It was reported that MIF induced rapid activation *requires* its co-receptor [CD44] . Positive_regulation CD44 IL1B 10657993 664318 Role of activating protein-1 and high mobility group-I ( Y ) protein in the *induction* of [CD44] gene expression by in vascular smooth muscle cells . Positive_regulation CD44 IL1B 10657993 664327 -Foster , L. C. , Wiesel , P. , Huggins , G. S , Pañares , R. , Chin , M. T. , Pellacani , A. , Perrella , M. A. Role of activating protein-1 and high mobility group-I ( Y ) protein in the *induction* of [CD44] gene expression by in vascular smooth muscle cells . Positive_regulation CD44 IL1B 12767055 1094261 1-40 Beta-amyloid protein fragment modulates the expression of [CD44] and CD71 on the astrocytoma cell line in the *presence* of and TNFalpha . Positive_regulation CD44 IL1B 15901130 1409113 The expression of [CD44] is *regulated* by , but binding of HMGA1 potentiates the transactivation of the CD44 promoter . Positive_regulation CD44 IL1B 16219515 1469084 It is concluded from the present study that human cervical [CD44] mRNA expression is *induced* by . Positive_regulation CD44 IL1B 18427719 1920736 The present study clearly suggests that HA binds [CD44] and inhibits *induced* MMP-1 and -13 expression via down-regulation of Phos-p38 in SW-1353 cells . Positive_regulation CD44 IL1B 9197378 438547 In addition , pretreatment of infected monocytes with a TNF-alpha synthesis inhibitor , RP 55778 , or with MAbs directed against IL-1beta , confirmed the *role* of TNF-alpha and in the regulation of CD18 , [CD44] , and CD54 expression . Positive_regulation CD44 IL1B 9550421 477799 In contrast , IL-4 and IL-13 were potent inhibitors of monocyte [CD44-HA] binding *induced* by either human serum or by IL-1alpha , , IL-3 , GM-CSF , or TNF-alpha . Positive_regulation CD44 IL1B 9685385 522055 Northern analysis showed that IL-1beta promoted a dose- and time dependent induction of CD44 mRNA which reached 6.6-fold after 48 h , and nuclear run-on analysis showed that *increased* the rate of [CD44] gene transcription within 8 h of stimulation . Positive_regulation CD44 ITGB2 15749731 1383168 Our data demonstrate that ligation of [CD44] *induces* phenotypic changes , cytoskeletal rearrangements and redistribution of PKC isoforms beta and delta , resulting in cell migration , as previously described for the cell surface receptor , . Positive_regulation CD44 ITGB2 8095198 211903 Despite higher ICAM-1 levels , cell aggregation assays revealed that adhesive interactions were not *involved* in the homotypic adhesion of B9/BM1 cells but rather that binding of [CD44] to endogenously synthesized hyaluronan was responsible . Positive_regulation CD44 MMP28 17295208 1771778 Both [CD44v6] and its ectodomain cleavage products were detected from ED 5 to ED 14 , and a broad-spectrum inhibitor *blocked* ectodomain cleavage in cultured stromal cells . Positive_regulation CD44 MMP7 17295208 1771793 Both [CD44v6] and its ectodomain cleavage products were detected from ED 5 to ED 14 , and a broad-spectrum inhibitor *blocked* ectodomain cleavage in cultured stromal cells . Positive_regulation CD44 PECAM1 12651608 1070634 Transfection of in MDA-MB-231 cells *caused* reduction in growth , loss of [CD44] , and acquisition of a ductal morphology . Positive_regulation CD44 PLAU 12402308 1009507 [CD44] stimulation by fragmented hyaluronic acid *induces* upregulation of and its receptor and subsequently facilitates invasion of human chondrosarcoma cells . Positive_regulation CD44 SELL 18391078 1944193 Our data indicate that , although PSGL-1 has a partial role in the transmigration of monocytes into the inflamed retina , has a key role in regulating recruitment of monocytes to lymphoid tissue from the blood during inflammation and that [CD44] is *required* to maintain CD62L ( + ) inflammatory monocytes within the circulation during inflammation . Positive_regulation CD44 TNF 10867614 706488 Furthermore , CEA , ICAM-1 and [CD44v6] were *increased* by plus calcitriol . Positive_regulation CD44 TNF 12090473 960024 and IL-8 *regulate* the expression and function of [CD44] variant proteins in human colon carcinoma cells . Positive_regulation CD44 TNF 12421945 1013715 We demonstrate the involvement , at least in part , of p38 MAPK in *induced* [CD44] expression in both monocytes and promonocytic THP-1 cells . Positive_regulation CD44 TNF 12767055 1094260 1-40 Beta-amyloid protein fragment modulates the expression of [CD44] and CD71 on the astrocytoma cell line in the *presence* of IL1beta and . Positive_regulation CD44 TNF 12867430 1141879 *induces* functionally active hyaluronan-adhesive [CD44] by activating sialidase through p38 mitogen activated protein kinase in lipopolysaccharide stimulated human monocytic cells . Positive_regulation CD44 TNF 12867430 1141880 In this study , we show that LPS induced [CD44 mediated HA (CD44-HA)] binding in monocytes is *regulated* by endogenously produced and IL-10 . Positive_regulation CD44 TNF 12867430 1141899 LPS induced [CD44-HA] binding in THP-1 cells was *regulated* by endogenously produced . Positive_regulation CD44 TNF 12867430 1141926 Subsequently , mediated p38 MAPK activation *induced* sialidase activity and [CD44-HA] binding . Positive_regulation CD44 TNF 12867430 1142085 Taken together , our results suggest that induced p38 MAPK activation may *regulate* the induction of functionally active HA-binding form of [CD44] by activating sialidase in LPS stimulated human monocytic cells . Positive_regulation CD44 TNF 15923644 1433707 We previously demonstrated that the c-Jun N-terminal kinase (JNK) , a mitogen activated protein kinase (MAPK) , differentially regulated LPS- but not *induced* [CD44] expression in monocytic cells . Positive_regulation CD44 TNF 15923644 1433708 Furthermore , *induced* [CD44] expression was regulated by AP-1 through the activation of the CaMK-II pathway , whereas LPS induced CD44 transcription was regulated specifically by Egr-1 through JNK activation . Positive_regulation CD44 TNF 16022734 1453198 [Heparan sulfate proteoglycan] *induces* the production of NO and by murine microglia . Positive_regulation CD44 TNF 16908592 1601621 However , little is known about the *role* of in [CD44] expression of cancer cells . Positive_regulation CD44 TNF 19965872 2199596 *promoted* [CD44] expression and moesin phosphorylation by protein kinase C , leading to the pericellular interaction of hyaluronan and CD44 . Positive_regulation CD44 TNF 20561612 2345352 Pretreatment of endometriotic stromal cells with PDTC attenuated *induced* expressions of [CD44s] , matrix metalloproteinase-9 , and vascular endothelial growth factor whereas reversed tumor necrosis factor-a reduced expressions of tissue inhibitor of metalloproteinase-1 revealed by reverse transcriptase polymerase chain reaction and Western blot analysis , suggesting that PDTC may represent a novel therapeutic strategy for treatment of endometriosis . Positive_regulation CD44 TNF 22386367 2572489 In MDA-MB-231 cells , *up-regulated* [CD44s] , CD44v3 and CD44v6 expression via p38 pathway . Positive_regulation CD44 TNF 7542295 314090 *Up-regulation* of [CD44] expression by is neutralized by interleukin-10 in Langerhans cells . Positive_regulation CD44 TNF 7542295 314094 We found 1 ) that significantly *up-regulated* the expression of [CD44] in a concentration dependent manner , 2 ) that IL-10 down-regulated the expression of CD44 in a concentration dependent manner , 3 ) that the effect of TNF-alpha or IL-10 was readily detectable as early as 24 h after the initiation of culture , and 4 ) that the simultaneous addition of TNF-alpha and IL-10 mutually neutralized the effect of each other . Positive_regulation CD44 TNF 7542295 314095 These data suggest that in the epidermal microenvironment the expression of [CD44] in LC may be reciprocally *regulated* by and IL-10 , both of which are known to be produced by surrounding keratinocytes . Positive_regulation CD44 TNF 8514850 221966 These results indicate that hyaluronate activation of [CD44] induces cytokine expression and macrophage derived IGF-1 production is *dependent* on expression . Positive_regulation CD44 TNF 8792802 381019 IL-1 beta showed the strongest stimulatory effect on the expression of ICAM-1 , preferentially induced the expression of VCAM-1 and CD-44 , and Et-1 strongly *stimulated* the upregulation of [CD-44] expression . Positive_regulation CD44 TNF 9197378 438546 In addition , pretreatment of infected monocytes with a TNF-alpha synthesis inhibitor , RP 55778 , or with MAbs directed against IL-1beta , confirmed the *role* of and IL-1beta in the regulation of CD18 , [CD44] , and CD54 expression . Positive_regulation CD44 TNF 9550421 477797 In contrast , IL-4 and IL-13 were potent inhibitors of monocyte [CD44-HA] binding *induced* by either human serum or by IL-1alpha , IL-1beta , IL-3 , GM-CSF , or . Positive_regulation CD44 TNF 9766501 538164 , but not IFN-gamma also *induced* the activation of LFA-1 , [CD44] and beta1 integrins on SR-91 cells . Positive_regulation CD44 TNF 9794764 543121 *induction* of [CD44] mediated leukocyte adhesion by sulfation . Positive_regulation CD44 TP63 17935121 1825568 Using chromatin immunoprecipitation , we were unable to show direct binding of p63 to the CD44 promoter , but found that specifically *increased* expression of [CD44] lacking variant exon 2 . Positive_regulation CD46 IL1B 12601067 1062389 *induced* [monocyte chemoattractant protein (MCP)-1] protein secretion was measured by enzyme linked immunosorbent assay . Positive_regulation CD46 IL1B 16249450 1471739 Expression of the NF-kappaB dependent genes IkappaB-alpha and [monocyte chemoattractant protein (MCP)-1] was *induced* in human islets by but not by high glucose . Positive_regulation CD46 IL1B 16597919 1589477 In the present study , the CGRP-1 receptor antagonist human ( h ) CGRP ( 8-37 ) ( 0.1-1 nM ) greatly amplified the production of *induced* [monocyte chemoattractant protein (MCP)-1] . Positive_regulation CD46 IL1B 17077666 1642381 *enhanced* the mRNA and/or protein levels of granulocyte-macrophage colony stimulating factor ( GM-CSF ) , IL-8 , and [monocyte chemotactic protein (MCP)-1] in HCE and IL-6 , IL-8 , MCP-3 , and regulated on T-cell activation expressed secreted ( RANTES ) in HCFs . Positive_regulation CD46 IL1B 8640847 362694 [MCP] expression was *up-regulated* by , but not by TNF alpha or INF gamma . Positive_regulation CD46 IL1B 9520946 493672 In the present study , we further examined the effects of GHSA on TNF-alpha- and *induced* HRPE IL-8 and [monocyte chemoattractant protein (MCP)-1] gene expression and protein secretion in HRPE . Positive_regulation CD46 TNF 15211029 1262157 We observed constitutive expression of interleukin (IL)-6 , IL-8 , granulocyte macrophage colony stimulating factor ( GM-CSF ) , and [monocyte chemoattractant protein (MCP)-1] in both human and baboon endothelial cells , and these cytokines were further *induced* by and LPS . Positive_regulation CD46 TNF 16081883 1466273 In vitro analysis indicates that alveolar cell expression of TNF-R2 is critical in the induction of epithelial [monocyte chemoattractant protein (MCP)-1] expression specifically in *response* to soluble , suggesting an important role for this receptor in bystander lung injury . Positive_regulation CD46 TNF 16794257 1631621 Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced *induced* IL-8 and [monocyte chemoattractant protein (MCP)-1] ( also called CCL2 ) expression in cultured human airway epithelial cells . Positive_regulation CD46 TNF 17673686 1842310 Using a transformed murine Clara cell line ( C22 ) , we observed that both LPS and *induced* production of keratinocyte derived chemokine ( KC ) and [monocyte chemoattractant protein (MCP)-1] . Positive_regulation CD46 TNF 19765578 2153528 induced mRNA *induction* of the chemokines , [monocyte chemoattractant protein (MCP)-1] and interleukin (IL)-8 , and the intercellular cell adhesion molecule ( ICAM)-1 , which are involved in adhesion between leukocytes and epithelial cells , was suppressed by M1-M4 , and M1 was the most efficacious . Positive_regulation CD46 TNF 21036166 2365496 Intracellular transfer of an inhibitory anti-Cx32 monoclonal antibody significantly enhanced *induced* [monocyte chemotactic protein (MCP)-1] and IL-6 expression , but overexpression of Cx32 abrogated TNF-a induced MCP-1 and IL-6 expression . Positive_regulation CD46 TNF 21116687 2389938 This PRL concentration ( comparable to plasma PRL levels in lactation ) also *induced* the upregulation of [monocyte chemoattractant protein (MCP)-1] , cyclooxygenase (Cox)-2 , and ephrin-B1 , whereas a higher concentration ( 500 ng/ml ) was required to upregulate and interleukin (IL)-1 . Positive_regulation CD46 TNF 22402367 2686451 In CMs , TLR2 and [monocyte chemoattractant protein (MCP)-1] mRNAs were *increased* by , PGN or H/R , whereas they were blunted by curcumin . Positive_regulation CD46 TNF 22754320 2623001 AP also effectively reduced *induced* mRNA expressions of [monocyte chemoattractant protein (MCP)-1] and interleukin (IL)-8 in a dose dependent manner . Positive_regulation CD46 TNF 8640847 362693 [MCP] expression was *up-regulated* by IL-1 beta , but not by or INF gamma . Positive_regulation CD47 MAP2K6 16776778 1599312 This function of [CD47] is *mediated* by the activation of Src and . Positive_regulation CD47 TNF 16924232 1692190 *induced* the expression of NF-kappaB regulated gene products cyclin D1 , c-Myc , matrix metalloproteinase-9 , survivin , X-linked inhibitor-of-apoptosis protein ( IAP ) , [IAP1] , Bcl-x ( L ) , A1/Bfl-1 and Fas associated death domain protein-like IL-1beta converting enzyme-inhibitory protein in wild-type MEF but not in PKR-/- cells . Positive_regulation CD47 TNF 17133355 1677736 In this report , we examined roles of nuclear factor-kappaB (NF-kappaB) and mitogen activated protein ( MAP ) kinases in *induced* expression of [IAP] genes . Positive_regulation CD47 TNF 17253597 1710340 Co-incubation of MPM cells with TNF-alpha and pyrrolidine dithiocarbamate ( PDTC ) , an NF-kappaB inhibitor , prevented *mediated* up-regulation of [IAP] gene expression levels . Positive_regulation CD47 TNF 17942934 1814222 The *induction* of various antiapoptotic gene products ( MMP-9 , cyclin D1 , COX-2 , [IAP1] , IAP2 , Bcl-2 , cFLIP , and XIAP ) by was also abolished in NQO2-/- cells . Positive_regulation CD47 TNF 18524990 1945498 In agreement with human mAb studies , transmigration of murine wild-type T helper type 1 cells across *activated* murine [CD47] ( -/- ) endothelium was reduced by 75 % plus or minus 2 % even though murine T cells appear to lack SIRPgamma . Positive_regulation CD47 TNF 22301394 2570939 Furthermore , the expression of antiapoptotic proteins ( IAP1 , [IAP2] , and Bcl-X ( L ) ) was *up-regulated* by and suppressed by CPT in HaCaT cells . Positive_regulation CD47 TNF 22498762 2601795 In addition , the expression of anti-apoptotic proteins ( [IAP1] , IAP2 , Bcl-X ( L ) ) was *up-regulated* by but suppressed by curcumin in HaCaT cells . Positive_regulation CD47 TNFSF10 22926077 2672519 We suggest that combined post-trauma [CD47] triggering , SHP-1 mediated NF?B suppression , and elevated levels *increase* patients ' CD47 expressing T cell apoptosis , thus contributing to subsequent T cell anergy . Positive_regulation CD48 TNF 16684368 1663368 Blockade of beta2 integrins and membrane bound IL-15 inhibited TNF production , whereas synthesis *increased* in the presence of [anti-CD48] and anti-CD244 ( 2B4 ) monoclonal antibodies . Positive_regulation CD5 TNF 1698380 141442 Data presented here and elsewhere suggest that this [CD5+] B-cell inducing activity is not *mediated* by IL-1 , IL-2 , IL-3 , IL-4 , IL-5 , IL-6 , IFN-gamma , GM-CSF , or . Positive_regulation CD55 CD14 1281489 205710 During neutrophil maturation , DAF decreased initially and then reemerged on maturing neutrophils concurrently with the appearance of CD16 ( Fc gamma RIII ) , whereas during monocyte maturation , [DAF] *increased* concurrently with up-regulation of . Positive_regulation CD55 F2R 16079188 1473866 Experiments with proteinase activated receptor-1 (PAR1) and PAR2 activating peptides (APs) showed that [DAF] expression *induced* by was PKC-alpha dependent ; Positive_regulation CD55 HBEGF 11889210 920192 These studies suggest that [DAF] expression in the midsecretory phase is *stimulated* by or other members of the EGF family and may function to protect the epithelial integrity of human endometrium in the face of increased complement expression . Positive_regulation CD55 IL1B 19446335 2090674 A low basal expression of [CD55] was strongly *enhanced* by IFN-gamma , and TNF-alpha . Positive_regulation CD55 IL1B 8640847 362692 The expression and function of [DAF] were *enhanced* by tumour necrosis factor alpha (TNF alpha) and . Positive_regulation CD55 IL1B 9737666 531554 Among the cytokines , IL-4 markedly , and moderately , *enhanced* the expression and the release of [DAF] . Positive_regulation CD55 IL1B 9737666 531555 Actinomycin D , cycloheximide , and brefeldin A inhibited the increase in [DAF] release *induced* by IL-4 and stimulation . Positive_regulation CD55 TNF 10770816 686082 Interferon (IFN)-gamma ( 10 U/ml/72 h ) and ( 1000 U/ml/72 h ) *increased* [DAF] expression up to a mean of 116 % and 45 % , respectively , above that in unstimulated cells . Positive_regulation CD55 TNF 14511240 1146563 *increased* EC [DAF] expression , detectable at 6 hr and maximal at 24-48 hr poststimulation . Positive_regulation CD55 TNF 19446335 2090673 A low basal expression of [CD55] was strongly *enhanced* by IFN-gamma , IL-1 beta and . Positive_regulation CD55 TNF 8640847 362691 The expression and function of [DAF] were *enhanced* by and interleukin-1 beta (IL-1 beta) . Positive_regulation CD55 TNF 9155641 431613 Messenger RNA stability studies suggested that partially *regulated* [DAF] gene expression by a posttranscriptional mechanism . Positive_regulation CD55 TNF 9730881 530308 In ChaGo K-1 and NCI-H596 lung cancer cell lines , IL-1alpha and *increased* [DAF] expression . Positive_regulation CD55 TNF 9730881 530311 ( 1 , 000 U/ml/72 h ) *increased* [DAF] expression up to a mean of 131 and 46 % , respectively . Positive_regulation CD58 IL1B 8525920 326446 In preliminary experiments with fluorescence microscopy we found that neither TNF-alpha nor *induce* [LFA3] in the same fashion as IFN-gamma . Positive_regulation CD58 ITGAL 7686816 222321 gamma-Interferon and/or tumor necrosis factor alpha upregulated the expression of CD54 by melanoma cells , but neither modulated that of [CD58] nor *induced* that of and CD2 . Positive_regulation CD58 TNF 19109405 2042207 Although both and IFN-gamma *increased* IL-8 synthesis and [CD58] expression by the HT-29 cells , only IFN-gamma reduced IL-8 production by IELs . Positive_regulation CD58 TNF 7686194 222115 ICAM-1 , but not [LFA-3] , was rapidly *up-regulated* by interleukin-1 (IL-1) , , and to some extent by interferon-gamma (IFN) and IL-6 , whereas IL-4 had variable low effects , if any . Positive_regulation CD58 TNF 8525920 326445 In preliminary experiments with fluorescence microscopy we found that neither nor IL-1 beta *induce* [LFA3] in the same fashion as IFN-gamma . Positive_regulation CD58 TNF 9255503 447715 Neither IFN-gamma nor *had* any effect on [LFA-3] expression on the cultured HCE cells . Positive_regulation CD59 TLR7 23584892 2778480 In mouse macrophages and human monocytes , activation *triggered* production of DHA derived monohydroxy metabolome markers and generation of [protectin D1 (PD1)] and resolvin D1 ( RvD1 ) . Positive_regulation CD59 TNF 19446335 2090680 The expression of [CD59] could be *augmented* by IL-1 beta , IL-6 and but was suppressed by IFN-gamma . Positive_regulation CD59 TNF 7688580 225384 The level of [CD59] was far greater than that of DAF or MCP on EC , and was slightly *up-regulated* by and down-regulated by IL-1 beta . Positive_regulation CD6 HES2 11200658 785419 A continuos increase of Cmax , AUC0-24 and [t1/2] over the five days caused by administration of HES was *due* to an accumulation of in serum . Positive_regulation CD68 TNF 18427128 1900084 Expression of , monocyte chemoattractant protein-1 , plasminogen activator inhibitor type 1 , and macrophage protein [CD68] *increased* , and expression of adiponectin and peroxisome proliferator activated receptor-gamma decreased in retroperitoneal adipose tissue from obese versus lean mice . Positive_regulation CD69 CD14 10936509 720677 Analysis of leukocyte subsets demonstrated that CD4 ( + ) T-cells , CD8 ( + ) T-cell , CD19 ( + ) B-cells , CD56 ( + ) natural killer ( NK ) -cells , and ( + ) monocytes *increased* the expression of [CD69] after stimulation with LPS . Positive_regulation CD69 EPHB2 10898494 712060 Here , we analyzed the effects of Vav on three known downstream targets of Ras , i. e. *activation* of and NFAT , and up-regulation of the activation antigen [CD69] . Positive_regulation CD69 EPHB2 20658220 2316948 To distinguish between the activation signalling and the death inducing pathway downstream of Fas , we generated a novel T cell line expressing a chimeric hCD8-FasC protein and found that stimulation with the anti-CD8 antibodies induced tyrosine phosphorylation of TCR-proximal proteins , *activation* of , p38 and JNK , and increased expression of [CD69] , Fas , and Fas ligand . Positive_regulation CD69 F2R 7510689 249937 Thrombin and agonist peptide induce early events of T cell activation and *synergize* with TCR cross linking for [CD69] expression and interleukin 2 production . Positive_regulation CD69 FAS 20658220 2316947 To distinguish between the activation signalling and the death inducing pathway downstream of Fas , we generated a novel T cell line expressing a chimeric hCD8-FasC protein and found that stimulation with the anti-CD8 antibodies *induced* tyrosine phosphorylation of TCR-proximal proteins , activation of Raf-1/ERK , p38 and JNK , and increased expression of [CD69] , , and Fas ligand . Positive_regulation CD69 JAG1 20304829 2244572 The interaction with endogenous transiently *induces* [CD69] expression on T cells , which prolongs retention in the lymphoid organs . Positive_regulation CD69 TNF 1577066 187374 We have investigated the possibility that gene expression and protein secretion could be *induced* in peripheral blood T cells through the [AIM/CD69 molecule] . Positive_regulation CD70 TLR7 17237405 1689875 In contrast to previous results in vitro , the expression of [CD70] on dendritic cells in vivo *requires* combined stimulation and is not significantly induced by stimulation of either pathway alone . Positive_regulation CD70 TNF 10221513 609430 In contrast to results described with B-type chronic lymphocytic leukemia , also characterized by high levels of circulating TNF , none of the tested samples showed a regulation of CD80 , CD86 , CD27 and [CD70] in *response* to . Positive_regulation CD72 EPHB2 11466342 839900 Although both [CD72] and BCR *induced* Btk dependent activation , CD72 mediated proliferation is more resistant to blocking of ERK activity than that of BCR , as shown by the proliferation response of B cells treated with PD98059 and dibutyryl cAMP , agents that inhibit ERK activity . Positive_regulation CD74 EPHB2 23252627 2737264 These changes were associated with up-regulation of MIF and its receptor [CD74] *activation* of ( extracellular-signal regulated kinase ) and NF-?B ( nuclear factor ?B ) signalling , prominent macrophage and T-cell infiltration , as well as up-regulation of Th1 [ T-bet and IFN? ( interferon ? ) ] and Th17 [ STAT3 ( signal transducer and activator of transcription 3 ) and IL ( interleukin)-17A ] as well as IL-1ß and TNFa ( tumour necrosis factor a ) . Positive_regulation CD79A AGR2 8418053 210478 The strongest salivary [IgA] antibody response was *induced* by conjugate given i.n. , but the addition of CT did not further enhance it . Positive_regulation CD79A AGR2 9607044 508380 The results showed that either mixed with or conjugated to rCTB could *induce* both mucosal [IgA] and systemic IgG antibodies to higher levels than in mice similarly immunized with AgI/II alone . Positive_regulation CD79A CD22 17223015 1703653 CD19 and do not merely *regulate* [BCR] signals independently , but they have their own regulatory network . Positive_regulation CD79A CD22 17631277 1775249 Because mediated signal regulation requires phosphorylation of CD22 by Lyn that localizes in lipid rafts and is *activated* by [BCR] , synthetic glycan ligand regulates localization of CD22 crucial for signal regulation . Positive_regulation CD79A CD22 18024433 1851805 Here we address the requirement of CD22 for SHP-1 recruitment and BCR regulation upon [BCR] ligation by antigen , which *induces* much stronger phosphorylation than anti-Ig Ab does . Positive_regulation CD79A CD22 18024433 1851814 We demonstrate that the mutant in which both Tyr ( 843 ) and Tyr ( 863 ) are replaced by phenylalanine ( CD22F5/6 ) recruits SHP-1 and *regulates* [BCR] signaling upon stimulation with antigen but not anti-Ig Ab . Positive_regulation CD79A CD22 9371816 466173 Ligation of CD19 and in vivo is likely to positively and negatively *regulate* [BCR] signaling , respectively , because CD19 crosslinking was more efficient than BCR crosslinking at inducing Vav phosphorylation . Positive_regulation CD79A CTGF 15012739 1183022 The present study was designed to elucidate the *role* of in diabetic nephropathy (DN) , [immunoglobulin A nephropathy (IgA-N)] , membranous nephropathy ( MN ) , and minimal change nephrotic syndrome ( MCNS ) . Positive_regulation CD79A EPHB2 12008033 940701 We compared the [BCR] *induced* intracellular [ Ca2+ ] transient , protein tyrosine phosphorylation and phosphorylation , furthermore , the activation of Elk-1 and CREB transcription factors . Positive_regulation CD79A EPHB2 12509924 1027509 [IgA] ( 1 ) *induces* the phosphorylation of , DNA synthesis and proliferation of HMC , and the effects of IgA ( 1 ) from patients with IgAN are stronger than that from healthy persons . Positive_regulation CD79A EPHB2 16210057 1464409 Eosinophil interaction with soluble [S-IgA] likely *involves* FcalphaRI ( CD89 ) and pathway activation . Positive_regulation CD79A EPHB2 22951891 2701736 In human mesangial cells in vitro , activation through mesangial IgA1 receptor ( CD71 ) controlled pro-inflammatory cytokine secretion and was *induced* by large-molecular-mass [IgA1] containing circulating immune complexes purified from patient sera . Positive_regulation CD79A GPR115 16291747 1509959 We performed in vitro kinase activity assays and show that [BCR-ABL] also leads to increased p110gamma activity and that this activation *requires* both and Ras signaling . Positive_regulation CD79A GPR132 16291747 1509948 We performed in vitro kinase activity assays and show that [BCR-ABL] also leads to increased p110gamma activity and that this activation *requires* both and Ras signaling . Positive_regulation CD79A GPR87 16291747 1510028 We performed in vitro kinase activity assays and show that [BCR-ABL] also leads to increased p110gamma activity and that this activation *requires* both and Ras signaling . Positive_regulation CD79A MAP2K6 9862707 556065 Analysis of the effects of the inhibitors on rosette formation between human eosinophils and IgA- or IgG coated beads revealed that activation of was not *required* for [IgA] binding after priming with IL-4 or IL-5 . Positive_regulation CD79A PECAM1 23233201 2724495 is *involved* in [BCR/ABL] signaling and may downregulate imatinib induced apoptosis of Philadelphia chromosome positive leukemia cells . Positive_regulation CD79A PIGR 1374892 186334 In the rat , secretion of polymeric [IgA] from serum into bile is *dependent* upon the presence of a functional that acts as a hepatocyte plasma membrane receptor for ligand binding and as a transcellular transport molecule . Positive_regulation CD79A PIGR 9565355 500901 The , which is constitutively expressed on the basolateral surface of secretory epithelial cells , *mediates* external translocation of polymeric [IgA] and pentameric IgM ( collectively called pIg ) to exocrine secretions . Positive_regulation CD79A PIGR 9649586 515374 The secretory [immunoglobulin A (IgA)] antibody response to infections of mucosal surfaces *requires* transport of IgA from the basal to apical surface of mucosal epithelial cells by a specific transport protein , the . Positive_regulation CD79A TCN1 11163403 763136 *induced* only modest levels of [IgA] in any of the samples tested ( range 2-7 fold increase ) . Positive_regulation CD79A TCN1 15752838 1380030 When administered with cholera toxin ( CT ) as adjuvant , with 40k-OMP not only elevated IgG Abs as noted above , but also *induced* [IgA] responses in serum but not in saliva . Positive_regulation CD79A TLR7 18925882 1977515 These data suggest that T regulatory cells may contribute to the suppression of allergic diseases by suppression of IgE and induction of IgG4 , whereas [IgA] production is *enhanced* by B-cell activation via and TLR9 . Positive_regulation CD79A TLR7 19710454 2133425 Strikingly , both responses required TLR7 signaling , but systemic IgA depended upon TLR7 signaling directly to B cells whereas mucosal [IgA] *required* signaling to lung dendritic cells and alveolar macrophages . Positive_regulation CD79A TLR7 20450285 2257178 T cell dependent and -independent [IgA] responses : *role* of signalling . Positive_regulation CD79A TLR7 20450285 2257198 Herein we review recent data , which points to a pivotal *role* of signalling in controlling T-cell dependent and independent [IgA] responses both at mucosal and systemic levels . Positive_regulation CD79A TLR7 22652800 2610614 Dual [BCR/TLR] engagement *induces* CSR to all Ig isotypes , as directed by cytokines , while engagement alone induces marginal CSR . Positive_regulation CD79A TNF 10892693 711289 The [IgA] production is partly *dependent* on IL-10 and . Positive_regulation CD79A TNF 11073104 748773 Moreover , inhibition of PI3K in these cells blocked the background and the *induced* [IgA] binding completely . Positive_regulation CD79A TNF 17393381 1721043 Moreover , [IgA-IC] from IgAN patients activated FcalphaRI and *induced* production . Positive_regulation CD79A TNF 18363466 1887871 is *involved* in the respiratory [IgA] immune response to injury . Positive_regulation CD79A TNF 19568710 2104592 The level of CD3 ( + ) , CD4 ( + ) , the ratio of CD4 and CD8 ( + ) , [IgA] , IgM , IgG and IL-2 decreased in patients with NSCLC on day 1 after operation , and the level of CD8 and *increased* compared to pre-operation . Positive_regulation CD79A TNF 2010162 154949 Polymeric [IgA] *induces* alpha secretion in a dose dependent fashion . Positive_regulation CD79A TNF 20452079 2268564 All strains *induced* [IgA] production while reduced production by small intestine cells . Positive_regulation CD79A TNF 8014525 262519 Thus , interactions between phagocytic host defense mechanisms and mucosal [IgA] may be *enhanced* by in the inflammatory milieu of the cystic fibrosis lung . Positive_regulation CD79B CD22 17223015 1703655 CD19 and do not merely *regulate* [BCR] signals independently , but they have their own regulatory network . Positive_regulation CD79B CD22 17631277 1775250 Because mediated signal regulation requires phosphorylation of CD22 by Lyn that localizes in lipid rafts and is *activated* by [BCR] , synthetic glycan ligand regulates localization of CD22 crucial for signal regulation . Positive_regulation CD79B CD22 18024433 1851806 Here we address the requirement of CD22 for SHP-1 recruitment and BCR regulation upon [BCR] ligation by antigen , which *induces* much stronger phosphorylation than anti-Ig Ab does . Positive_regulation CD79B CD22 18024433 1851815 We demonstrate that the mutant in which both Tyr ( 843 ) and Tyr ( 863 ) are replaced by phenylalanine ( CD22F5/6 ) recruits SHP-1 and *regulates* [BCR] signaling upon stimulation with antigen but not anti-Ig Ab . Positive_regulation CD79B CD22 9371816 466175 Ligation of CD19 and in vivo is likely to positively and negatively *regulate* [BCR] signaling , respectively , because CD19 crosslinking was more efficient than BCR crosslinking at inducing Vav phosphorylation . Positive_regulation CD79B EPHB2 12008033 940706 We compared the [BCR] *induced* intracellular [ Ca2+ ] transient , protein tyrosine phosphorylation and phosphorylation , furthermore , the activation of Elk-1 and CREB transcription factors . Positive_regulation CD79B GPR115 16291747 1510055 We performed in vitro kinase activity assays and show that [BCR-ABL] also leads to increased p110gamma activity and that this activation *requires* both and Ras signaling . Positive_regulation CD79B GPR132 16291747 1510044 We performed in vitro kinase activity assays and show that [BCR-ABL] also leads to increased p110gamma activity and that this activation *requires* both and Ras signaling . Positive_regulation CD79B GPR87 16291747 1510124 We performed in vitro kinase activity assays and show that [BCR-ABL] also leads to increased p110gamma activity and that this activation *requires* both and Ras signaling . Positive_regulation CD79B PECAM1 23233201 2724496 is *involved* in [BCR/ABL] signaling and may downregulate imatinib induced apoptosis of Philadelphia chromosome positive leukemia cells . Positive_regulation CD79B TLR7 22652800 2610624 Dual [BCR/TLR] engagement *induces* CSR to all Ig isotypes , as directed by cytokines , while engagement alone induces marginal CSR . Positive_regulation CD80 CD14 15367342 1294720 PBMCs of the healthy donor cocultured with rhGM-CSF plus CI for 40 hours had the typical morphology of DCs , with decreased expression , and *increased* CD83 , [CD80] and CD86 expressions . Positive_regulation CD80 CD14 15661814 1381987 Furthermore , the *upregulation* of [CD80] , CD86 , MHC class II and interleukin-6 by ( + ) monocytes following activation with specific TLR ligands was decreased ( P < 0.05 ) in samples obtained following exercise compared with at rest . Positive_regulation CD80 CHI3L1 14511234 1146561 Flow cytometry analysis demonstrated that *increased* the expression levels of major histocompatibility complex II , CD23 , and [CD80] , in Raji human B-cell lymphoma similarly to an antibody against CD40 . Positive_regulation CD80 CHI3L1 7533092 292210 Studies on the up-regulation of B7-1 and B7-2 on resting B cells showed that soluble *up-regulated* [B7-1] and B7-2 expression on B cells . Positive_regulation CD80 FAS 12944991 1133871 We found that adenovirus mediated rat gene transfer *induced* ( i ) expression of rat [B7-1/Fas] chimeric molecules in osteosarcoma cells , ( ii ) activation of murine T cells , ( iii ) apoptosis of murine osteosarcoma cells in the presence of anti-rat B7-1 mAb in vitro , and ( iv ) therapeutic effects more prominently than B7-1 gene transfer on the development of pulmonary metastasis and survival of mice . Positive_regulation CD80 IL1B 7533084 292204 We have demonstrated : 1 ) that the [B7-1] expression of LC is reproducibly *up-regulated* by either GM-CSF , TNF-alpha , IL-1 alpha , , or IL-4 in a dose- and time dependent manner , 2 ) that GM-CSF exhibits the most active effect on B7-1 up-regulation in each experiment , 3 ) that IFN-gamma or IL-10 profoundly inhibits the B7-1 expression of LC in a dose- and time dependent manner , and 4 ) that the down-regulatory ability of IFN-gamma or IL-10 neutralizes the activity of up-regulatory cytokines . Positive_regulation CD80 IL1B 8648174 363692 These data indicate that or TNF-alpha is not *sufficient* to induce [B7-1] expression on Langerhans cells in vivo . Positive_regulation CD80 MAP2K6 24157331 2875318 pCry1Ac induced upregulation of CD86 and [CD80] was partially *inhibited* by the inhibitor . Positive_regulation CD80 TLR7 17471428 1737780 Innate immunity , including *mediated* expression of the B7 costimulatory molecules [CD80] and CD86 , is critical for vaccine immunity . Positive_regulation CD80 TLR7 17471428 1737800 We determined *induced* monocyte [CD80/CD86] expression by flow cytometry and vaccine antibody responses by hemagglutination inhibition . Positive_regulation CD80 TLR7 17471428 1737820 The mean increase in *induced* [CD80] ( + ) monocytes was reduced in older , compared with young , adults by 68 % ( P=.0002 ) , and each decile increase of CD80 ( + ) cells was associated with an 8.5 % increase in mean number of vaccine strains with a > or =4-fold titer increase ( P=.01 ) and a 3.8 % increase in mean number of strains with a postvaccine titer > or =1 : 64 ( P=.037 ) . Positive_regulation CD80 TLR7 21617192 2538562 We therefore evaluated the ability of to *induce* [CD80] in human cultured podocytes . Positive_regulation CD80 TLR7 24586760 2920227 stimulation *induced* upregulation of CD40 , [CD80] and CD86 . Positive_regulation CD80 TNF 10221513 609431 In contrast to results described with B-type chronic lymphocytic leukemia , also characterized by high levels of circulating TNF , none of the tested samples showed a regulation of [CD80] , CD86 , CD27 and CD70 in *response* to . Positive_regulation CD80 TNF 10384156 624810 Neither IFN-gamma plus nor CD40 stimulation significantly *induced* [B7-1] or up-regulated B7-2 on human myeloma cell line or primary myeloma cells from six of seven patients . Positive_regulation CD80 TNF 11008105 735744 An early production of by exposed monocytes was *followed* by the production of IL-10 and a reduced expression of HLA-DR and the costimulatory molecules [B7-1] and B7-2 , while other adhesion receptors remained unaffected . Positive_regulation CD80 TNF 11302869 803622 In contrast , , interleukin 1beta (IL1beta) , IL2 , and IL4 *had* no effect on either [CD80] or CD86 levels . Positive_regulation CD80 TNF 14511233 1146556 markedly *increased* the expression on DC of major histocompatibility complex ( MHC ) and the costimulatory molecules , CD40 , [CD80] and CD86 . Positive_regulation CD80 TNF 14632659 1170643 markedly *increased* the surface expression of major histocompatibility complex ( MHC ) and costimulatory molecules , CD86 and [CD80] , on DCs . Positive_regulation CD80 TNF 15950500 1440585 On the other hand , no [CD80] expression was detected in the primary cells or cell lines in the *presence* or absence of either human or pig IFN-gamma . Positive_regulation CD80 TNF 17142787 1653778 The expression of [CD80] and PD ligand-1 on monocytes could be *induced* in vitro by IFN-gamma and that were produced abundantly in RA-derived synovial fluid ( SF ) . Positive_regulation CD80 TNF 19278729 2063557 Stimulation with , S. gordonii , PGN , LTA , or LP all *resulted* in increased surface expression of MHCII , [CD80] , and CD86 , compared to unstimulated BM-DCs . Positive_regulation CD80 TNF 23867288 2835182 We elucidated that IFN-? up-regulated the expression of MHC II , CD40 , [CD80] , CD83 and CD86 molecules on BMDCs , down-regulated the activity of pinocytosis and phagocytosis by BMDCs , and *induced* higher levels of IL-12 and secreted by BMDCs . Positive_regulation CD80 TNF 24157331 2875310 Cry1Ac protoxin from Bacillus thuringiensis promotes macrophage activation by upregulating [CD80] and CD86 and by *inducing* IL-6 , MCP-1 and cytokines . Positive_regulation CD80 TNF 7533084 292202 We have demonstrated : 1 ) that the [B7-1] expression of LC is reproducibly *up-regulated* by either GM-CSF , , IL-1 alpha , IL-1 beta , or IL-4 in a dose- and time dependent manner , 2 ) that GM-CSF exhibits the most active effect on B7-1 up-regulation in each experiment , 3 ) that IFN-gamma or IL-10 profoundly inhibits the B7-1 expression of LC in a dose- and time dependent manner , and 4 ) that the down-regulatory ability of IFN-gamma or IL-10 neutralizes the activity of up-regulatory cytokines . Positive_regulation CD80 TNF 7621870 315638 Furthermore , IL-10 led to the down-regulation of various surface antigens , especially of CD86 and CD54 , whereas and TRAP *enhanced* the expression of MHC class I and II antigens and of the accessory molecules CD40 , CD54 , [CD80] and CD86 . Positive_regulation CD80 TNF 8648174 363691 These data indicate that IL-1 beta or is not *sufficient* to induce [B7-1] expression on Langerhans cells in vivo . Positive_regulation CD80 TNF 8881659 390809 We have already demonstrated that the expression of [B7-1] of murine LC is significantly *enhanced* by GM-CSF , IL-1 or . Positive_regulation CD81 EPHB2 14676841 1211199 Therefore , we conclude that [CD81] stimulates synthesis of phosphoinositides with the recruitment of Shc to the plasma membrane via PTB domain , and this sequence of events *induces* activation of . Positive_regulation CD81 PCSK9 19489072 2102869 Interestingly , stable expression of or a more active membrane bound form of the protein ( PCSK9-ACE2 ) *resulted* in a marked reduction in [CD81] and LDLR expression . Positive_regulation CD82 EPHB2 19048108 1999251 A phospholipase Cgamma (PLCgamma) inhibitor and shRNA , as well as an inhibitor , *reduced* [ST6Gal1] and FUT9 mRNA levels and inhibited effects of L1 on neurite outgrowth and cell survival . Positive_regulation CD82 IL1B 17200188 1680643 In contrast , rapidly *stimulated* [KAI1] expression at the transcript level and at the protein level . Positive_regulation CD82 TNF 11212267 785832 Our results demonstrated that expression of [KAI1/CD82] in PC-14 cells expressing mutant p53 could be *augmented* by , and that transfer of the gene for a specific inhibitor of NF-kappaB , IkappaB alphaSR ( mutant IkappaB alpha ; NF-kappaB super-repressor ) , into PC-14 cells could inhibit this augmentation . Positive_regulation CD83 EPHB2 15454113 1301143 These results suggest that PA and TNF-alpha induce the up-regulation of [CD83] and that their action is *regulated* by and JNK . Positive_regulation CD83 IL1B 15560757 1341018 Stimulation of day 8 DCs from AD patients with TNF-alpha and *enhanced* the expression of [CD83] and CD86 and restored the production of IL-16 . Positive_regulation CD83 IL1B 15730393 1377480 Our results show that IFN-gamma , but not , *augmented* the surface expression of CD80 , [CD83] and CD86 molecules without inducing IL-12 production from DCs . Positive_regulation CD83 PECAM1 15114667 1241418 Activation via agonistic anti-CD38 mAb induces up-regulation of CD83 expression and IL-12 secretion , whereas disruption of interaction *inhibits* [CD83] expression , IL-12 secretion and MDDC induced allogeneic T cell proliferation . Positive_regulation CD83 TLR7 18802111 1964580 We also found that ligands , and to some extent TNF-alpha , were able to *increase* the expression of MHC class II and [CD83] in endothelial cells , which might suggest a role for fish endothelial cells and TNF-alpha in Ag presentation . Positive_regulation CD83 TNF 10201904 605654 *induced* the cluster formation of the cells and the enhancement of cell surface expression levels of [CD83] , CD86 , and HLA-DR , and T cell stimulatory capacity , whereas the capacities for the endocytosis and the chemotactic migration were suppressed in these cells . Positive_regulation CD83 TNF 12930919 1164046 On the contrary , neutralizing significantly *increased* the IGF-I induced up-regulation of [CD83] and CD40 . Positive_regulation CD83 TNF 15454113 1301134 Phosphatidic acid and *induce* the expression of [CD83] through mitogen activated protein kinase pathway in a CD34+ hematopoietic progenitor cell line , KG1 . Positive_regulation CD83 TNF 15454113 1301135 In the *presence* of , PA but not lyso-PA up-regulated [CD83] on KG1 cells . Positive_regulation CD83 TNF 15454113 1301138 However , the *up-regulation* of [CD83] by on KG1 was significantly abrogated by PD98059 , a specific inhibitor of ERK kinase , but was enhanced by SP600125 , a JNK inhibitor . Positive_regulation CD83 TNF 15454113 1301139 Bis-indolylmaleimide , an inhibitor of protein kinase C , partially blocked the up-regulation of [CD83] and ERK phosphorylation *induced* by PA and . Positive_regulation CD83 TNF 15454113 1301142 These results suggest that PA and *induce* the up-regulation of [CD83] and that their action is regulated by ERK and JNK . Positive_regulation CD83 TNF 15560757 1341014 Stimulation of day 8 DCs from AD patients with and IL-1beta *enhanced* the expression of [CD83] and CD86 and restored the production of IL-16 . Positive_regulation CD83 TNF 15905506 1409330 Stimulation of PBMCs with PHA , , or LPS *leads* to the up-regulation of the full-length [CD83] transcript and to a strong down-regulation of two of the three smaller transcripts . Positive_regulation CD83 TNF 16358375 1492945 treatment *induced* DCs maturation and up-regulation of CD80 , CD86 and [CD83] . Positive_regulation CD83 TNF 18755511 1975322 Functional antagonism by GM-CSF on *induced* [CD83] expression in human neutrophils . Positive_regulation CD83 TNF 18755511 1975323 *induced* expression of [CD83] in leukocytes is mediated by NF-kappab . Positive_regulation CD83 TNF 18755511 1975326 The aim of our present study was to investigate the underlying mechanism of a unique functional antagonism between GM-CSF and induced *up-regulation* of [CD83] in human neutrophils . Positive_regulation CD83 TNF 18802111 1964579 We also found that TLR ligands , and to some extent , were able to *increase* the expression of MHC class II and [CD83] in endothelial cells , which might suggest a role for fish endothelial cells and TNF-alpha in Ag presentation . Positive_regulation CD83 TNF 23867288 2835185 We elucidated that IFN-? up-regulated the expression of MHC II , CD40 , CD80 , [CD83] and CD86 molecules on BMDCs , down-regulated the activity of pinocytosis and phagocytosis by BMDCs , and *induced* higher levels of IL-12 and secreted by BMDCs . Positive_regulation CD83 TNF 9845382 553419 Additional treatment *induced* prominent dendritic processes and surface expression of [CD83] on CMRF-44+ DCs . Positive_regulation CD86 CD14 11243109 479756 The expression of was increased and the expressions of MHC-II , B7-1 , [B7-2] and VCAM-1 were also *up-regulated* . Positive_regulation CD86 CD14 15367342 1294721 PBMCs of the healthy donor cocultured with rhGM-CSF plus CI for 40 hours had the typical morphology of DCs , with decreased expression , and *increased* CD83 , CD80 and [CD86] expressions . Positive_regulation CD86 CHI3L1 7533092 292211 Studies on the up-regulation of B7-1 and B7-2 on resting B cells showed that soluble *up-regulated* B7-1 and [B7-2] expression on B cells . Positive_regulation CD86 IL1B 15560757 1341024 Stimulation of day 8 DCs from AD patients with TNF-alpha and *enhanced* the expression of CD83 and [CD86] and restored the production of IL-16 . Positive_regulation CD86 IL1B 15730393 1377482 Our results show that IFN-gamma , but not , *augmented* the surface expression of CD80 , CD83 and [CD86] molecules without inducing IL-12 production from DCs . Positive_regulation CD86 IL1B 17359392 1712660 While IFN-gamma up-regulated the expression of HLA-DR , and TNF-alpha *up-regulated* the expression of [CD86] in CNEC . Positive_regulation CD86 IL1B 8648174 363696 Taken together , our present results suggest that is *required* for the upregulation of Ia , ICAM-1 , [B7-2] , and CD40 , while GM-CSF is required for the upregulation of B7-1 and B7-2 , although it still remains unclear why the injected GM-CSF could not augment B7-1 expression on Langerhans cells in vivo and why anti-IL-1 beta Ab did not suppress the upregulation of Ia , ICAM-1 , or CD40 on cultured Langerhans cells . Positive_regulation CD86 JAG1 12798309 1098748 The expression of MHC class II , [CD86] , and CD83 Ags on DCs and CD40 ligand (L) associated IL-12 p70 production from DCs were *up-regulated* by the membrane . Positive_regulation CD86 LBP 19265128 2045464 *up-regulated* DC expression of CD40 , CD80 , [CD86] , and MHC class II molecules ; Positive_regulation CD86 MAP2K6 24157331 2875325 pCry1Ac induced upregulation of [CD86] and CD80 was partially *inhibited* by the inhibitor . Positive_regulation CD86 TLR7 17471428 1737790 Innate immunity , including *mediated* expression of the B7 costimulatory molecules CD80 and [CD86] , is critical for vaccine immunity . Positive_regulation CD86 TLR7 17471428 1737810 We determined *induced* monocyte [CD80/CD86] expression by flow cytometry and vaccine antibody responses by hemagglutination inhibition . Positive_regulation CD86 TLR7 17563917 1763041 ES , but not AWH , inhibited BMDC cytokine and chemokine production and co-stimulatory molecule expression ( CD40 , [CD86] and MHC class II ) *induced* by ligation . Positive_regulation CD86 TNF 10201904 605655 *induced* the cluster formation of the cells and the enhancement of cell surface expression levels of CD83 , [CD86] , and HLA-DR , and T cell stimulatory capacity , whereas the capacities for the endocytosis and the chemotactic migration were suppressed in these cells . Positive_regulation CD86 TNF 10384156 624813 Neither IFN-gamma plus nor CD40 stimulation significantly induced B7-1 or *up-regulated* [B7-2] on human myeloma cell line or primary myeloma cells from six of seven patients . Positive_regulation CD86 TNF 11008105 735745 An early production of by exposed monocytes was *followed* by the production of IL-10 and a reduced expression of HLA-DR and the costimulatory molecules B7-1 and [B7-2] , while other adhesion receptors remained unaffected . Positive_regulation CD86 TNF 11238627 790806 SB203580 , an inhibitor of the p38 MAPK , but not the extracellular signal regulated kinase l/2 pathway blocker PD98059 , inhibited the up-regulation of CD1a , CD40 , CD80 , [CD86] , HLA-DR , and the DC maturation marker CD83 *induced* by LPS and . Positive_regulation CD86 TNF 11302869 803625 In contrast , , interleukin 1beta (IL1beta) , IL2 , and IL4 *had* no effect on either CD80 or [CD86] levels . Positive_regulation CD86 TNF 12230943 988350 Class II MHC , B7-1 , [B7-2] , and ICAM-1 levels in HKC cells were significantly *increased* by the costimulation of IFN-gamma and . Positive_regulation CD86 TNF 12233883 988786 Interferon-gamma (IFN-gamma) induced the cultured salivary gland epithelial cells to express HLA class I antigens , HLA-DR antigens , CD80 , and ICAM-1 , while *induced* the expression of HLA class I antigens , CD80 , [CD86] , and VCAM . Positive_regulation CD86 TNF 14511233 1146557 markedly *increased* the expression on DC of major histocompatibility complex ( MHC ) and the costimulatory molecules , CD40 , CD80 and [CD86] . Positive_regulation CD86 TNF 14632659 1170644 markedly *increased* the surface expression of major histocompatibility complex ( MHC ) and costimulatory molecules , [CD86] and CD80 , on DCs . Positive_regulation CD86 TNF 14966193 1235799 We report that stimulation of Mycobacterium tuberculosis secretory antigen- and alpha matured BALB/c mouse bone marrow dendritic cells ( BMDCs ) with anti-CD80 monoclonal antibody *up-regulated* [CD86] levels on the cell surface . Positive_regulation CD86 TNF 15560757 1341020 Stimulation of day 8 DCs from AD patients with and IL-1beta *enhanced* the expression of CD83 and [CD86] and restored the production of IL-16 . Positive_regulation CD86 TNF 16358375 1492946 treatment *induced* DCs maturation and up-regulation of CD80 , [CD86] and CD83 . Positive_regulation CD86 TNF 17359392 1712659 While IFN-gamma up-regulated the expression of HLA-DR , IL-1beta and *up-regulated* the expression of [CD86] in CNEC . Positive_regulation CD86 TNF 19278729 2063559 Stimulation with , S. gordonii , PGN , LTA , or LP all *resulted* in increased surface expression of MHCII , CD80 , and [CD86] , compared to unstimulated BM-DCs . Positive_regulation CD86 TNF 23353170 2734188 The DCs were then co-cultured with UC-MSCs in the *presence* of for 2 days , and the expressions of CD11c and [CD86] on DCs and IL-12 level in the culture medium was detected using flow cytometry and ELISA , respectively . Positive_regulation CD86 TNF 23867288 2835188 We elucidated that IFN-? up-regulated the expression of MHC II , CD40 , CD80 , CD83 and [CD86] molecules on BMDCs , down-regulated the activity of pinocytosis and phagocytosis by BMDCs , and *induced* higher levels of IL-12 and secreted by BMDCs . Positive_regulation CD86 TNF 24157331 2875312 Cry1Ac protoxin from Bacillus thuringiensis promotes macrophage activation by upregulating CD80 and [CD86] and by *inducing* IL-6 , MCP-1 and cytokines . Positive_regulation CD86 TNF 7621870 315647 Furthermore , IL-10 led to the down-regulation of various surface antigens , especially of CD86 and CD54 , whereas and TRAP *enhanced* the expression of MHC class I and II antigens and of the accessory molecules CD40 , CD54 , CD80 and [CD86] . Positive_regulation CD86 TNF 9802563 544020 In addition , TGF-beta1 also acted directly on the intermediate stage of DC to prevent their over-maturation , which results in a preferential decrease in MHC class II , but not in [CD86] , in the *presence* of . Positive_regulation CD8A CD14 20921523 2337557 We demonstrate here that the HO-1 inhibitor tin mesoporphyrin ( SnMP ) induces *activation* , proliferation , and maturation of naive CD4 ( + ) and [CD8] ( + ) T cells via interactions with ( + ) monocytes in vitro . Positive_regulation CD8A FAS 11067907 747073 In this study we show that maximal Ag-dependent accumulation of transferred TCR-transgenic [CD8] ( + ) T cells *requires* ( CD95/APO-1 ) expression by the adoptive hosts . Positive_regulation CD8A FAS 11414736 829017 The IFN-gamma promoted significant upregulation of Fas on the surface of colon carcinoma cells and sensitized these targets to *mediated* apoptosis and Ag-specific [CD8] ( + ) cytotoxic T lymphocyte ( CTL ) -mediated lysis involving a Fas based effector mechanism . Positive_regulation CD8A FAS 11509617 848603 Thus , perforin and were not *involved* in CD4 ( + ) and [CD8] ( + ) T cell mediated restriction of MTB growth . Positive_regulation CD8A FAS 15709041 1373280 Finally , we found that interleukin 7 (IL-7) increases *mediated* CD4 ( + ) and [CD8] ( + ) T-cell death induced by HIV-1 ( LAI ) . Positive_regulation CD8A FAS 16507991 1529623 Here we show that binding of Fas ligand to Fas activates p38 MAPK in CD8+ T cells and that activation of this pathway is required for *mediated* [CD8+] T-cell death . Positive_regulation CD8A FAS 17045460 1641814 Not only absence of MHC-I and upregulation , but also resistance to cytokine induced killing of beta-cells and a complete lack of CXCL-10 ( IP10 ) production in islets *led* to a lack of islet infiltration and impaired activation of autoaggressive CD4 ( + ) and [CD8] ( + ) T-cells in these mice . Positive_regulation CD8A FAS 17853940 1802089 Elevated levels of IL-10 early in the response was key to the loss of CD4 ( + ) T cells , whereas [CD8] ( + ) T cell deletion was *dependent* on a prolonged TNF-alpha response , IL-10 , and upregulation of . Positive_regulation CD8A FAS 18485588 1944904 Its expression in tumors protects tumor cells from *mediated* apoptosis and the cytotoxic activity of tumor specific [CD8] ( + ) T cells . Positive_regulation CD8A FAS 9045916 416673 While expression could be *induced* in B-1 cells to a comparable level as that in B-2 cells by cross linking [CD40L-CD8alpha] with an anti-CD8alpha antibody , the sensitivity to Fas mediated apoptosis in B-1 cells was significantly reduced compared with B2 cells . Positive_regulation CD8A FAS 9743345 532386 Differential expression of and Fas ligand in acute and chronic graft-versus-host disease : up-regulation of Fas and Fas ligand *requires* [CD8+] T cell activation and IFN-gamma production . Positive_regulation CD8A IFI27 21326316 2453096 Our findings indicate a potential *role* for in the suppressive capacity of peptide induced regulatory [CD8] ( + ) Ti cells through effects on the expression of Foxp3 and the synthesis of TGFß . Positive_regulation CD8A IL1B 10845914 700712 Interleukin-1beta converting enzyme ( ICE ) inhibitors do not prevent the recovery of IL-1beta bioactivity after allorecognition , indicating that allospecific [CD8] ( + ) T cells may *induce* the release of bioactive via mechanism ( s ) other than ICE activation . Positive_regulation CD8A ITGAL 24158516 2889568 Essential *role* of in [CD8+] T-cell accumulation and activation in adipose tissue . Positive_regulation CD8A ITGB2 19483086 2107897 *regulates* [CD8+] T cell activation via T cell receptor mediated and LFA-1 mediated Erk1/2 signal pathways . Positive_regulation CD8A ITGB2 19483086 2107899 Thus , *contributes* to [CD8+] T cell activation through two distinct signal pathways . Positive_regulation CD8A ITGB2 20569988 2302870 signaling is *required* for the generation of central memory [CD8] ( + ) T cells in priming phase . Positive_regulation CD8A ITGB2 20805505 2318280 Furthermore , PYK2 is essential for LFA-1 mediated [CD8] T-cell adhesion and *costimulation* of CD8 T-cell migration . Positive_regulation CD8A ITGB2 20805505 2318285 Thus , PYK2 facilitates *dependent* [CD8] T-cell responses and promotes CD8 T-cell short lived effector fate , suggesting that PYK2 may be an interesting therapeutic target to suppress exacerbated CD8 T-cell responses . Positive_regulation CD8A JAG1 15100260 1239597 Thus , expressed by the non-bone marrow derived cells in the liver actively *cause* [CD8] ( + ) T cell accumulation through TCR activated ICAM-1 adhesion , but the liver can also passively sequester activated CD8 ( + ) T cells that do not recognize intrahepatic Ag , through VCAM-1 adhesion . Positive_regulation CD8A JAG1 17579024 1763677 The role of CD4+ T cells in promoting [CD8+] T cell effector activity in *response* to transplant in vivo has not been reported . Positive_regulation CD8A JAG1 17675471 1777334 We show that in vivo accumulation of DNA vaccine encoded is *required* for the efficient induction of [CD8] ( + ) T cell responses . Positive_regulation CD8A JAG1 20729328 2313177 We further demonstrated that delivering to DCs via hDectin-1 using anti-hDectin-1-Ag conjugates *resulted* in potent Ag-specific [CD8] ( + ) T cell responses . Positive_regulation CD8A JAG1 23319735 2738325 Finally , IVE-TB *induced* strong IFN-? ( + ) /TNF-a ( + ) [CD8] ( + ) and TNF-a ( + ) /IL-2 ( + ) CD154 ( + ) /CD4 ( + ) T cell responses in PBMC from long-term latently M. tuberculosis infected individuals . Positive_regulation CD8A JAG1 23636062 2784477 Activation markers , cross-presentation of exogenous , and *activation* of [CD8] ( + ) T cells are much increased in Swap-70 ( -/- ) DCs . Positive_regulation CD8A JAG1 7809629 292527 However , pathogens or particulate that are internalized into phagosomes of macrophages ( M phi s ) *stimulate* [CD8] T cells . Positive_regulation CD8A SERPINA5 19818719 2164513 The but not pCI/S ( L39V ) DNA vaccination *induced* L ( d ) /S ( 28-39 ) -specific [CD8] T cell responses . Positive_regulation CD8A STAT4 17114431 1651451 IL-12 programmed long-term [CD8+] T cell responses *require* . Positive_regulation CD8A TCN1 17114496 1651690 mediated responses markedly *enhanced* the appearance and local accumulation of highly differentiated ( CD44 ( high ) ) CD4 and [CD8] endogenous tumor infiltrating T cells when compared with that of untreated tumor bearing mice . Positive_regulation CD8A TLR7 19954299 2172426 Therefore , although [CD8] ( + ) T cells can be directly *activated* by , accessory cells must play an essential role in the activation of effective functions such as IFN-gamma production . Positive_regulation CD8A TLR7 23589622 2778639 We further show that this downregulation is dependent on TLR signaling , and that the *activated* naive [CD8] ( + ) T cells are blocked from entering GALT . Positive_regulation CD8A TLR7 24928999 2946894 We found that the : CL097 could simultaneously *activate* [CD8] ( + ) T cells , B cells , and NK cells plus block Treg suppression of T cells and B cells . Positive_regulation CD8A TNF 10226053 610321 Perforin independent [CD8] ( + ) T-cell mediated cytotoxicity of alveolar epithelial cells is preferentially *mediated* by : relative insensitivity to Fas ligand . Positive_regulation CD8A TNF 11744830 888830 Results showed that M-stimulated production of interleukin (IL)-10 and *increases* in CD4 ( + ) and [CD8] ( + ) cells of African infected patients and uninfected study subject ; Positive_regulation CD8A TNF 1347307 179221 I . Transforming growth factor-beta and *induce* [CD8] expression on CD8- thymic subsets including the CD25+CD3-CD4-CD8- pre-T cell subset . Positive_regulation CD8A TNF 1347307 179224 Of 15 cytokines tested , only transforming growth factor ( TGF-beta ) and *induced* [CD8] ( Lyt-2 ) , while no cytokine was able to induce CD4 on CD25+CD3-CD4-CD8- thymocytes . Positive_regulation CD8A TNF 1347307 179228 In contrast , neither TGF-beta nor *induced* [CD8] expression on splenic CD4+CD8- T cells . Positive_regulation CD8A TNF 15162447 1253055 Furthermore , we found that the interaction of SEB stimulated [CD8] ( + ) CTL with lung epithelial cells *induced* an increase in secretion . Positive_regulation CD8A TNF 17618911 1769822 Alpha *contributes* to [CD8] ( + ) T cell survival in the transition phase . Positive_regulation CD8A TNF 17618911 1769823 In contrast , deficiency in both recipients and donor CD8 ( + ) effector T cells significantly *reduced* [CD8] ( + ) T cell survival . Positive_regulation CD8A TNF 17853940 1802088 Elevated levels of IL-10 early in the response was key to the loss of CD4 ( + ) T cells , whereas [CD8] ( + ) T cell deletion was *dependent* on a prolonged response , IL-10 , and upregulation of Fas . Positive_regulation CD8A TNF 21038470 2339070 The induction of [CD8] ( + ) Treg by anti-CD3 mAb *requires* and signaling through the NF-?B cascade . Positive_regulation CD8A TNF 21239709 2386787 These results indicate that hapten application to the skin of sensitized animals initiates an inflammatory response promoting hapten primed CD8 T cell localization to the challenge site through *induced* ICAM-1 expression and [CD8] T cell activation to produce IFN-? and IL-17 through endothelial cell presentation of hapten . Positive_regulation CD8A TNF 21709152 2455807 receptor 1 *mediates* dendritic cell maturation and [CD8] T cell response through two distinct mechanisms . Positive_regulation CD8A TNF 22230585 2550965 Impaired production of by dendritic cells of older adults *leads* to a lower [CD8+] T cell response against influenza . Positive_regulation CD8A TNF 23222736 2707934 Cytotoxic effector function of CD4 independent , [CD8] ( + ) T cells is *mediated* by . Positive_regulation CD8A TNF 23526821 2772442 A useful model for in vivo CD8 CTL in the absence of exogenous pathogens is the alloantigen-driven parent-into F1 model of acute graft-versus-host disease ( GVHD ) characterized by a strong *dependent* donor antihost [CD8] CTL T cell response . Positive_regulation CD8A TNF 24080983 2863363 Further study demonstrated that Schwann cells promoted activation of [CD8] ( + ) T cells and induced expression of , FasL , and PDL1 on CD8 ( + ) T cells , in return , CD8 ( + ) T cells *induced* obvious apoptosis of Schwann cells . Positive_regulation CD8A TNF 24211847 2875903 Blocking studies suggested that *enhanced* PD-L1 expression and the suppressive activity of the [CD8regs] generated . Positive_regulation CD8A TNFSF10 14872508 1208504 engagement selectively *activated* human CD4 , rather than [CD8] , T cells and augmented IFNgamma production . Positive_regulation CD8A TNFSF10 17127445 1667939 However , a *role* of as a fine tuning regulator of the immune system , especially in the regulation of [CD8+] T cell activation and memory , has been also demonstrated . Positive_regulation CD8A TNFSF10 18354179 1887177 We first demonstrate that does not *contribute* to the [CD8] ( + ) T cell response to Listeria monocytogenes strain expressing OVA ( LmOVA ) in the presence of CD4 ( + ) T cells . Positive_regulation CD8A TNFSF10 21940678 2497480 The current study examined the *role* of in the pulmonary [CD8] T cell response to a clinically significant IAV [ A/PR/8/34 ( PR8 ; Positive_regulation CD8B FAS 11067907 747074 In this study we show that maximal Ag-dependent accumulation of transferred TCR-transgenic [CD8] ( + ) T cells *requires* ( CD95/APO-1 ) expression by the adoptive hosts . Positive_regulation CD8B FAS 11414736 829018 The IFN-gamma promoted significant upregulation of Fas on the surface of colon carcinoma cells and sensitized these targets to *mediated* apoptosis and Ag-specific [CD8] ( + ) cytotoxic T lymphocyte ( CTL ) -mediated lysis involving a Fas based effector mechanism . Positive_regulation CD8B FAS 15709041 1373282 Finally , we found that interleukin 7 (IL-7) increases *mediated* CD4 ( + ) and [CD8] ( + ) T-cell death induced by HIV-1 ( LAI ) . Positive_regulation CD8B FAS 16507991 1529624 Here we show that binding of Fas ligand to Fas activates p38 MAPK in CD8+ T cells and that activation of this pathway is required for *mediated* [CD8+] T-cell death . Positive_regulation CD8B FAS 17045460 1641815 Not only absence of MHC-I and upregulation , but also resistance to cytokine induced killing of beta-cells and a complete lack of CXCL-10 ( IP10 ) production in islets *led* to a lack of islet infiltration and impaired activation of autoaggressive CD4 ( + ) and [CD8] ( + ) T-cells in these mice . Positive_regulation CD8B FAS 17853940 1802092 Elevated levels of IL-10 early in the response was key to the loss of CD4 ( + ) T cells , whereas [CD8] ( + ) T cell deletion was *dependent* on a prolonged TNF-alpha response , IL-10 , and upregulation of . Positive_regulation CD8B FAS 18485588 1944905 Its expression in tumors protects tumor cells from *mediated* apoptosis and the cytotoxic activity of tumor specific [CD8] ( + ) T cells . Positive_regulation CD8B FAS 9045916 416674 While expression could be *induced* in B-1 cells to a comparable level as that in B-2 cells by cross linking [CD40L-CD8alpha] with an anti-CD8alpha antibody , the sensitivity to Fas mediated apoptosis in B-1 cells was significantly reduced compared with B2 cells . Positive_regulation CD8B FAS 9743345 532388 Differential expression of and Fas ligand in acute and chronic graft-versus-host disease : up-regulation of Fas and Fas ligand *requires* [CD8+] T cell activation and IFN-gamma production . Positive_regulation CD8B IFI27 21326316 2453102 Our findings indicate a potential *role* for in the suppressive capacity of peptide induced regulatory [CD8] ( + ) Ti cells through effects on the expression of Foxp3 and the synthesis of TGFß . Positive_regulation CD8B IL1B 10845914 700713 Interleukin-1beta converting enzyme ( ICE ) inhibitors do not prevent the recovery of IL-1beta bioactivity after allorecognition , indicating that allospecific [CD8] ( + ) T cells may *induce* the release of bioactive via mechanism ( s ) other than ICE activation . Positive_regulation CD8B ITGB2 19483086 2107900 Thus , *contributes* to [CD8+] T cell activation through two distinct signal pathways . Positive_regulation CD8B ITGB2 20569988 2302871 signaling is *required* for the generation of central memory [CD8] ( + ) T cells in priming phase . Positive_regulation CD8B ITGB2 20805505 2318281 Furthermore , PYK2 is essential for LFA-1 mediated [CD8] T-cell adhesion and *costimulation* of CD8 T-cell migration . Positive_regulation CD8B ITGB2 20805505 2318286 Thus , PYK2 facilitates *dependent* [CD8] T-cell responses and promotes CD8 T-cell short lived effector fate , suggesting that PYK2 may be an interesting therapeutic target to suppress exacerbated CD8 T-cell responses . Positive_regulation CD8B JAG1 15100260 1239598 Thus , expressed by the non-bone marrow derived cells in the liver actively *cause* [CD8] ( + ) T cell accumulation through TCR activated ICAM-1 adhesion , but the liver can also passively sequester activated CD8 ( + ) T cells that do not recognize intrahepatic Ag , through VCAM-1 adhesion . Positive_regulation CD8B JAG1 17675471 1777335 We show that in vivo accumulation of DNA vaccine encoded is *required* for the efficient induction of [CD8] ( + ) T cell responses . Positive_regulation CD8B JAG1 20729328 2313178 We further demonstrated that delivering to DCs via hDectin-1 using anti-hDectin-1-Ag conjugates *resulted* in potent Ag-specific [CD8] ( + ) T cell responses . Positive_regulation CD8B JAG1 23319735 2738326 Finally , IVE-TB *induced* strong IFN-? ( + ) /TNF-a ( + ) [CD8] ( + ) and TNF-a ( + ) /IL-2 ( + ) CD154 ( + ) /CD4 ( + ) T cell responses in PBMC from long-term latently M. tuberculosis infected individuals . Positive_regulation CD8B JAG1 23636062 2784478 Activation markers , cross-presentation of exogenous , and *activation* of [CD8] ( + ) T cells are much increased in Swap-70 ( -/- ) DCs . Positive_regulation CD8B JAG1 7809629 292528 However , pathogens or particulate that are internalized into phagosomes of macrophages ( M phi s ) *stimulate* [CD8] T cells . Positive_regulation CD8B STAT4 17114431 1651452 IL-12 programmed long-term [CD8+] T cell responses *require* . Positive_regulation CD8B TLR7 19954299 2172427 Therefore , although [CD8] ( + ) T cells can be directly *activated* by , accessory cells must play an essential role in the activation of effective functions such as IFN-gamma production . Positive_regulation CD8B TLR7 24928999 2946895 We found that the : CL097 could simultaneously *activate* [CD8] ( + ) T cells , B cells , and NK cells plus block Treg suppression of T cells and B cells . Positive_regulation CD8B TNF 1347307 179225 Of 15 cytokines tested , only transforming growth factor ( TGF-beta ) and *induced* [CD8] ( Lyt-2 ) , while no cytokine was able to induce CD4 on CD25+CD3-CD4-CD8- thymocytes . Positive_regulation CD8B TNF 1347307 179229 In contrast , neither TGF-beta nor *induced* [CD8] expression on splenic CD4+CD8- T cells . Positive_regulation CD8B TNF 15162447 1253057 Furthermore , we found that the interaction of SEB stimulated [CD8] ( + ) CTL with lung epithelial cells *induced* an increase in secretion . Positive_regulation CD8B TNF 17618911 1769824 In contrast , deficiency in both recipients and donor CD8 ( + ) effector T cells significantly *reduced* [CD8] ( + ) T cell survival . Positive_regulation CD8B TNF 17853940 1802091 Elevated levels of IL-10 early in the response was key to the loss of CD4 ( + ) T cells , whereas [CD8] ( + ) T cell deletion was *dependent* on a prolonged response , IL-10 , and upregulation of Fas . Positive_regulation CD8B TNF 21038470 2339071 The induction of [CD8] ( + ) Treg by anti-CD3 mAb *requires* and signaling through the NF-?B cascade . Positive_regulation CD8B TNF 21709152 2455808 receptor 1 *mediates* dendritic cell maturation and [CD8] T cell response through two distinct mechanisms . Positive_regulation CD8B TNF 23526821 2772443 A useful model for in vivo CD8 CTL in the absence of exogenous pathogens is the alloantigen-driven parent-into F1 model of acute graft-versus-host disease ( GVHD ) characterized by a strong *dependent* donor antihost [CD8] CTL T cell response . Positive_regulation CD8B TNF 24080983 2863366 Further study demonstrated that Schwann cells promoted activation of [CD8] ( + ) T cells and induced expression of , FasL , and PDL1 on CD8 ( + ) T cells , in return , CD8 ( + ) T cells *induced* obvious apoptosis of Schwann cells . Positive_regulation CD8B TNFSF10 14872508 1208505 engagement selectively *activated* human CD4 , rather than [CD8] , T cells and augmented IFNgamma production . Positive_regulation CD8B TNFSF10 17127445 1667940 However , a *role* of as a fine tuning regulator of the immune system , especially in the regulation of [CD8+] T cell activation and memory , has been also demonstrated . Positive_regulation CD9 HBEGF 9396739 468833 HB-EGF and [CD9] at both the mRNA and the protein level were up-regulated after differentiation into macrophages , and further expression of was *induced* by the addition of OxLDL or lysophosphatidylcholine . Positive_regulation CD9 IL1B 9356353 461841 Ctx combined with TNFalpha or to *produce* a synergistic increase in [p24] antigen production in U1 promonocytic cells . Positive_regulation CD9 TNF 9356353 461840 Ctx combined with or IL-1beta to *produce* a synergistic increase in [p24] antigen production in U1 promonocytic cells . Positive_regulation CD93 TNF 16490927 1528616 Whereas recombinant ( rTNF-alpha ) slightly *up-regulated* [CD93] expression on the U937 cells , recombinant interleukin-1beta ( rIL-1beta ) , recombinant interleukin-2 ( rIL-2 ) , recombinant interferon-gamma ( rIFN-gamma ) and lipopolysaccharide (LPS) had no effect . Positive_regulation CDA RARB 20447390 2268435 In MDA-MB-231 cells , only [2CdA] , F-ara-A , and ATRA *induced* 2 expression without any notable effects in combined treatment . Positive_regulation CDC123 TNFSF10 22355661 2520854 To investigate the resistance mechanisms in *stimulated* human fibrosarcoma ( [HT1080] ) cells , we developed a computational model to analyze the temporal activation profiles of cell survival ( I?B , JNK , p38 ) and apoptotic ( caspase-8 and -3 ) molecules in wildtype and several ( FADD , RIP1 , TRAF2 and caspase-8 ) knock-down conditions . Positive_regulation CDC14A NES 11901424 922822 Disrupting the *led* to [Cdc14A] being localized in nucleoli , which in unperturbed cells selectively contain Cdc14B ( ref. 1 ) . Positive_regulation CDC20 ID1 18372912 1938167 The negative effect of on APC ( Cdh1 ) *results* in suppression of APC ( Cdh1 ) -induced Aurora A and [Cdc20] degradation , leading to failure in cytokinesis . Positive_regulation CDC20 STK39 18083840 1837017 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation CDC25A EPHB2 16818510 1581139 PM-20 thus represents a novel class of tumor growth inhibitor that inhibits mainly [Cdc25A] , is *dependent* on activation , and has a considerable margin of selectivity for tumor cells compared with normal cells . Positive_regulation CDC25A EPHB2 19244340 2055133 Finally , and importantly , *induced* [Cdc25A] degradation can elicit cell cycle arrest in early embryos . Positive_regulation CDC25C CAPN8 9045698 416433 Accordingly , the GEF activity of [CDC25] ( Mm ) was *increased* severalfold by the Ca2+ dependent protease that cleaves around a PEST-like region ( residues 798-853 ) , producing C-terminal fragments of 43-56 kDa . Positive_regulation CDC25C EPHB2 17382881 1715605 Inhibition of activation partially *inhibits* T48 phosphorylation , [Cdc25C] activation , and mitotic induction . Positive_regulation CDC37 TFPI2 18922470 1977213 We show that Cdc37 and associate in Hsp90 complexes in yeast and in human tumor cells , and that PP5/Ppt1 *regulates* phosphorylation of [Ser13-Cdc37] in vivo , directly affecting activation of protein kinase clients by Hsp90-Cdc37 . Positive_regulation CDC37 TNF 11864612 917591 induced recruitment and activation of the IKK complex *require* [Cdc37] and Hsp90 . Positive_regulation CDC42 CTGF 15319369 1303749 Conversely , [Cdc42] activity was *increased* by . Positive_regulation CDC42 F2R 17373694 1720564 LNCaP migration was enhanced twofold and [Rac1/Cdc42] signaling was *activated* by stimulation of and PAR-2 . Positive_regulation CDC42 FGD3 18363964 1887901 Indeed , FGD1 and FGD3 induced significantly different morphological changes in HeLa Tet-Off cells : whereas FGD1 induced long finger-like protrusions , *induced* broad sheet-like protrusions when the level of GTP bound [Cdc42] was significantly increased by the inducible expression of FGD3 . Positive_regulation CDC42 IGFBP1 10792618 689482 These data demonstrate that preferentially *activates* [Cdc42] and induces the formation of long filopodia with unique substratum attachments that produce a novel mode of locomotion . Positive_regulation CDC42 ITGB2 11254681 794073 Stromal cell derived factor-1 induced activation during in vivo migration of T cell hybridoma cells *requires* Gq/11 , RhoA , and myosin , as well as Gi and [Cdc42] . Positive_regulation CDC42 ITGB2 11254681 794092 We show here that zeta associated protein 70-induced activation *requires* neither [Cdc42] and RhoA nor contraction and is thus quite different from that induced by SDF-1 . Positive_regulation CDC42 ITGB2 15004185 1217403 Furthermore , inhibition of receptor engagement or tyrosine kinase activity *blocked* the DeltaM5 induced activation of [Cdc42] as well as the killing of these bacteria . Positive_regulation CDC42 ITGB2 15832298 1397581 Inhibition of , but not of CD32 , the major neutrophil signaling Fc receptor , prevented Streptococcus induced NADPH oxidase dependent respiratory burst , and blocking of C3b/iC3b formation *inhibited* Streptococcus induced activation of [Cdc42] , a small GTPase critically involved in transmitting pro-inflammatory signals to the cytoskeleton . Positive_regulation CDC42 PECAM1 19574426 2111381 Furthermore , the expression of promoted filopodia formation and *increased* the protein expression levels of [Cdc42] , a Rho GTPase that is known to promote the formation of filopodia . Positive_regulation CDC42 PLAU 12719789 1084088 Endogenous RhoA , but not Rac1 or [Cdc42] , was significantly activated in *response* to . Positive_regulation CDC42 S1PR3 23142484 2735666 Inhibition of receptors *prevented* E2-induced activation of [Cdc42] , supporting the important role of the S1P receptor in E2 signaling . Positive_regulation CDC42 TNF 17599063 1774551 The results of this study suggest that PH-mediated plasma membrane targeting of FAN is critically involved in *induced* [Cdc42] activation and cytoskeleton reorganization . Positive_regulation CDC45 FOXO1 22265405 2545053 Instead , we show that and Fkh2 are *required* for the clustering of early origins and their association with the key initiation factor [Cdc45] in G1 phase , suggesting that Fkh1 and Fkh2 selectively recruit origins to emergent replication factories . Positive_regulation CDC6 EPHB2 21088490 2355026 From the above data , we deduce ERK dependent CDK2 activation is due in part to *dependent* [Cdc6] expression . Positive_regulation CDC7 IFI27 24511319 2914429 Western blotting showed that there were no apparent changes of protein levels of Cyclin E1 , while expression significantly declined and the levels of [CDC7] and CDK7 obviously *increased* . Positive_regulation CDC73 ALOX5 1650153 162973 Taken together , our studies indicate that [PAF] can significantly augment lung NK cell activity and that this effect is *dependent* on PKC , <5-lipoxygenase> , and extracellular calcium . Positive_regulation CDC73 ALOX5 3152458 104194 This suggests that <5-lipoxygenase> *dependent* mediators and [PAF] are involved in allergic contact dermatitis and that these mediators play only a minor role in irritant dermatitis . Positive_regulation CDC73 ALOX5 6089913 41330 The specific <5-lipoxygenase> inhibitor , 6,8-de-epoxy-6,9- ( phenylimino ) delta 6,8-prostaglandin I1 ( U-60257 ) , *inhibits* [PAF-acether] , but not leukotriene B4-mediated chemotaxis . Positive_regulation CDC73 ALOX5 8415804 234041 Although the early pulmonary vascular response ( < 10 min ) to PAF is dependent on cyclooxygenase products , the sustained response ( after 10 min ) can not be explained by either <5-lipoxygenase> or cyclooxygenase products but may be *mediated* directly by [PAF] receptors . Positive_regulation CDC73 ANGPT1 16617006 1624480 *mediated* endothelial [PAF] synthesis requires the activation of the p38 and p42/44 MAPKs , PI3K intracellular signalling pathways , and a secreted phospholipase A(2) ( sPLA ( 2 ) -V ) . Positive_regulation CDC73 CHI3L1 8245706 236926 On the other hand , the release of [platelet activating factor (PAF)] induced by opsonized particles was *enhanced* only by and not by CGP41-251 and CGP44-800 . Positive_regulation CDC73 EDN2 2051719 161785 In addition , *induced* a significant increase in the production of [PAF] by isolated glomeruli ( Basal , 81 +/- 10 pg/mg protein ; endothelin , 10 ( -7 ) M , 140 +/- 18 pg/mg protein ) . Positive_regulation CDC73 EDN2 8898708 393078 *stimulates* phosphoinositide hydrolysis and [PAF] synthesis in brain microvessels . Positive_regulation CDC73 HBEGF 17322418 1747796 Increased alkaline phosphatase ( AP ) activity after PAF treatment in AP-HB-EGF fusion construct transfected SMCs indicated that [PAF] *induced* the release of within 1 min. Gelatin zymography data showed that PAF stimulated MMP-2 activity and MMP-9 activity within 1 min . Positive_regulation CDC73 IL1B 10447739 577414 We conclude that CRH and [PAF] can *induce* the expression of , but this is not obligatory for increased PGE2 release , and the effect of these stimuli on COX-2 expression is a direct , IL-1beta independent effect . Positive_regulation CDC73 IL1B 1519663 196908 Stimulation of isolated mouse alveolar macrophages with recombinant murine or IL-1 alpha *resulted* in rapid , dose dependent , and cell concentration dependent increases in [PAF] secretion . Positive_regulation CDC73 IL1B 16807360 1612751 In circular muscle , exogenous [PAF] *induced* sequential formation of IL-6 , H ( 2 ) O ( 2 ) , , and PAF . Positive_regulation CDC73 IL1B 16829183 1591450 Both TNF-alpha and induced HUVEC platelet activating factor (PAF) production and [PAF] was *required* for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine ) . Positive_regulation CDC73 IL1B 7882558 298858 and IL-6 *stimulate* the production of [platelet activating factor (PAF)] by cultured rabbit synovial cells . Positive_regulation CDC73 IL1B 8080039 270818 and tumor necrosis factor-alpha *induce* [PAF] production by endothelium , and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist . Positive_regulation CDC73 ITGB2 7902855 245056 Ligation of was not *sufficient* for [PAF] synthesis suggesting that an additional receptor was involved . Positive_regulation CDC73 LBP 7541418 310465 Moreover , LeuM3 , 28C5 , and 18E12 mAbs that were themselves unable to stimulate the synthesis of PAF blocked [PAF] synthesis *initiated* by complex . Positive_regulation CDC73 LBP 7541418 310470 was *required* for synthesis of [PAF] by MO . Positive_regulation CDC73 MAP2K6 10606930 655848 The results showed that TNF alpha , IL-1 alpha and [PAF] *induced* serine phosphorylation of MKK3 and , and p38 MAP kinase activation in BECs . Positive_regulation CDC73 MUC16 9620929 510743 In rat tracheas studied by in situ hybridization , [PAF] *induced* MUC5 gene expression in epithelial cells that stained for mucosubstances . Positive_regulation CDC73 PLAT 1521562 196952 Using a perfused rat hindleg system , release of from endothelial cells could be *induced* by [platelet activating factor (PAF)] , bradykinin , substance P , thrombin , carbachol and A23187 , while this release was inhibited by mepacrine and by nor-dihydroguaiaretic acid . Positive_regulation CDC73 TGM2 7679111 211189 The finding that competitive inhibitors of significantly *inhibited* [C-PAF] release , enhancement of MC540 staining , and externalization of phosphatidylserine , strongly suggest a role for this enzyme in the enhancement of phospholipid transbilayer movement . Positive_regulation CDC73 TNF 10409262 629950 Both and interleukin-1 modestly *increased* plasma [PAF-AH] activity and mRNA levels in liver and spleen , suggesting that they may partly mediate the effect of LPS on PAF-AH . Positive_regulation CDC73 TNF 10435033 634214 ( 4 ) the synthesis of [PAF] *induced* by . Positive_regulation CDC73 TNF 11080081 749566 *increased* the production of [PAF] and NO . Positive_regulation CDC73 TNF 12428690 1014870 Synthesis of [PAF] was not *inducible* by in murine F10-M3 melanoma cells . Positive_regulation CDC73 TNF 15702351 1382763 Finally , up to 2 mug/ml , [PAF] did not *induce* the production of pro-inflammatory cytokines such as IL-6 , IL-8 , and . Positive_regulation CDC73 TNF 1668105 176687 [PAF] *induced* maximal synthesis 2-3 hr after monocyte stimulation as assessed by dot blotting of cell associated TNF alpha using polyclonal anti-TNF antibody . Positive_regulation CDC73 TNF 16829183 1591449 Both and IL-1beta induced HUVEC platelet activating factor (PAF) production and [PAF] was *required* for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine ) . Positive_regulation CDC73 TNF 18180165 1863036 *induces* [platelet activating factor (PAF)] synthesis in many inflammatory cells . Positive_regulation CDC73 TNF 18180165 1863041 We found that , although both cultures synthesized PAF at a similar basal rate , *induced* [PAF] synthesis in adipocytes was 7-fold higher than in preadipocytes . Positive_regulation CDC73 TNF 18180165 1863046 Wortmannin enhanced *dependent* [PAF] synthesis in adipocytes but not in preadipocytes , indicating the negative control by PI3K in mature cells . Positive_regulation CDC73 TNF 20016469 2204612 , which is assumed to mediate the interaction between mesangial cells and podocytes , also *induces* the expression of [platelet activating factor (PAF)] . Positive_regulation CDC73 TNF 20423922 2437236 In rats , increased hydraulic conductivity 2.5-fold over baseline and [PAF] *increased* it 5-fold ; Positive_regulation CDC73 TNF 2137857 128811 The peptide HDMNKVLDL ( antiflammin-2 ) inhibits the synthesis of [platelet activating factor (PAF)] *induced* by or phagocytosis in rat macrophages and human neutrophils , and by thrombin in vascular endothelial cells . Positive_regulation CDC73 TNF 2266661 147299 Inhibitors of PAF synthesis , such as plasma alpha 1-proteinase inhibitor and an anti-inflammatory peptide , blocked changes induced by TNF , PAF receptor antagonists inhibited changes *induced* by [PAF] and also by . Positive_regulation CDC73 TNF 2801951 119976 Since *stimulates* [PAF] synthesis in vitro , we tested the hypothesis that PAF mediates TNF induced lung injury in vivo using specific PAF receptor antagonists . Positive_regulation CDC73 TNF 3049910 99305 and IL-1 *stimulate* the synthesis and release of [platelet activating factor (PAF)] by neutrophils and vascular endothelial cells . Positive_regulation CDC73 TNF 3049910 99315 Low concentrations of this antiproteinase and of human plasma alpha 1-antichymotrypsin inhibited *induced* [PAF] synthesis in neutrophils , macrophages , and vascular endothelial cells . Positive_regulation CDC73 TNF 3119758 80235 Synthesis of [PAF] in *response* to was also detected in rat polymorphonuclear neutrophils , but not in human tumor cells and dermal fibroblasts . Positive_regulation CDC73 TNF 3261295 95986 About 30 % of [PAF] produced in *response* to either or IL-1 is released into the medium , whereas approximately 70 % remains cell associated . Positive_regulation CDC73 TNF 3261295 96006 Experiments with labeled precursors show that [PAF] is synthesized de novo in *response* to . Positive_regulation CDC73 TNF 3261295 96016 This suggests that [PAF] is synthesized by the same pathway in *response* to or IL-1 . Positive_regulation CDC73 TNF 3366898 93068 In the present study , we have shown that ( a ) *caused* [PAF] production in bowel tissue ; Positive_regulation CDC73 TNF 7516414 257605 These results suggest that the angiogenic effect of is , at least in part , *mediated* by [PAF] synthesized from monocytes and/or endothelial cells infiltrating the Matrigel plug . Positive_regulation CDC73 TNF 7681399 214257 In conclusion , the *enhancement* of [PAF] responses by , associated with functional characteristics of differentiation in Mono Mac 6 cells , may represent a specific mechanism of cooperative interaction between PAF and TNF in inflammation , sepsis , immunoregulation and atherogenesis . Positive_regulation CDC73 TNF 7821968 285552 We have shown previously that endotoxin , tumour necrosis factor (TNF) and platelet activating factor (PAF) are important in the pathogenesis of bowel injury , and that endotoxin and *induce* [PAF] formation in bowel tissue . Positive_regulation CDC73 TNF 7882905 289169 Because the release of [PAF] is *stimulated* by , this study was designed to measure the effects of polyI : C on TNF induced lung inflammation and injury . Positive_regulation CDC73 TNF 8080039 270817 Interleukin-1 beta and *induce* [PAF] production by endothelium , and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist . Positive_regulation CDC73 TNF 9394802 468194 These data suggest that [PAF] , which is released immediately or shortly after LPS injection , *induces* the expression of through the activation of NF-kappa B . Positive_regulation CDCA5 CAPN8 17416967 1722871 Recent evidence supports A beta induction of a *dependent* cleavage of the cyclin dependent kinase 5 (cdk5) regulatory protein [p35] that contributes to tau hyperphosphorylation and neuronal death . Positive_regulation CDH1 ARSA 24184502 2896990 *Induction* of membranous expression of [E-cadherin] by <5-ASA> is a novel mechanism for mucosal healing in colitis that might impede tumor progression by modulation of GnT-III expression . Positive_regulation CDH1 CAPN8 12393869 1035847 The *role* of in the proteolytic cleavage of [E-cadherin] in prostate and mammary epithelial cells . Positive_regulation CDH1 CAPN8 15538719 1387440 We have previously identified a novel , *dependent* proteolytic cleavage of [E-cadherin] that resulted in the generation of a stable 100-kDa E-cadherin fragment ( E-cad ( 100 ) ) in prostate epithelial cells in response to cell death stimuli . Positive_regulation CDH1 CAPN8 21825064 2485387 H. pylori induced activation *results* in cleavage of [E-cadherin] to produce a 100-kDa truncated form and induce relocalization of E-cadherin and ß-catenin . Positive_regulation CDH1 CCND1 11950881 930347 Furthermore , [E-cadherin] *induced* , nuclear reduplication , and karyokinesis in the absence of cytokinesis , resulting in myocytes with two closely opposed nuclei . Positive_regulation CDH1 CCND1 24001804 2862179 Therefore , suppression of [E-cadherin] expression via hypermethylation or transcriptional *activation* of c-myc and may be involved in BDCM induced cell proliferation in different tissues of male F344 rats . Positive_regulation CDH1 CTGF 17951996 1844522 The expression of alpha-smooth muscle actin ( alpha-SMA ) and [E-cadherin] upon the *stimulation* by recombinant human ( rhCTGF ) in cultured human tubular epithelial cell line ( HK-2 ) was detected by real-time RT-PCR and Western blot . Positive_regulation CDH1 CTGF 20393144 2282070 These data demonstrate the linking role of miRNA-192/215 and ZEB2 in *mediated* changes in [E-cadherin] expression . Positive_regulation CDH1 EPHB2 19037103 2029549 activation also *led* to induction of metalloproteinase ( MMP)-9 and cleavage of [E-cadherin] at two specific sites . Positive_regulation CDH1 EPHB2 22328534 2642865 Taken together , data indicated that the expression of GSK-3a , ß-catenin and [E-cadherin] could be negatively *regulated* by Tß4 induced phosphorylation . Positive_regulation CDH1 FLG 22796440 2645582 Reduced expression of epidermal growth factor receptor , [E-cadherin] , and occludin in the skin of flaky tail mice is *due* to and loricrin deficiencies . Positive_regulation CDH1 FLG 22796440 2645588 Our findings suggest that the observed reductions in EGFR , [E-cadherin] , and occludin expression were *due* to deficiency accompanied with subsequent loricrin deficiency and disruption of the SIRT1 pathway in the skin of Flg ( ft ) mice . Positive_regulation CDH1 GJB2 11429787 831687 We also found that induction of [E-cadherin] and subsequent formation of a cell adhesion complex were *induced* in HepG2 cells by expression . Positive_regulation CDH1 GJB2 11429787 831689 These results suggest that the *induction* of [E-cadherin] and formation of the cell adhesion complex by expression contribute to the reversal of some malignant phenotypes of HepG2 cells . Positive_regulation CDH1 HBEGF 17875687 1796184 Our data here clearly indicated the distinct *role* of in the regulation of [E-cadherin] expression and the epithelial-mesenchymal transition . Positive_regulation CDH1 HBEGF 17875687 1796187 Expression of noncleaved in pancreatic cells *resulted* in the up-regulation of [E-cadherin] through suppression of ZEB1 , which is a transcriptional repressor of E-cadherin . Positive_regulation CDH1 HBEGF 17875687 1796188 Moreover , *up-regulation* of [E-cadherin] by not only resulted in cellular morphologic change but also decreased cell motility and enhanced apoptotic sensitivity in response to gemcitabine-erlotinib treatment . Positive_regulation CDH1 HBEGF 22592159 2643446 Immunostaining revealed *induced* expression of the mesenchymal protein vimentin and decreased expression of [E-cadherin] , as well as nuclear translocation of ß-catenin . Positive_regulation CDH1 MMP28 12507936 1027445 The sum effect of MMP inhibitors demonstrated that NO-induced activation of may *cause* the degradation of [E-cadherin] and the subsequent dissociation of beta-catenin , thereby contributing to the cytosolic accumulation of beta-catenin and nuclear formation of beta-catenin/LEF-1 complex . Positive_regulation CDH1 MMP7 11595727 870203 *mediates* extracellular cleavage of [E-cadherin] from prostate cancer cells : a key mechanism in hepatocyte growth factor/scatter factor induced cell-cell dissociation and in vitro invasion . Positive_regulation CDH1 MMP7 11595727 870207 Both recombinant human ( rh-Matrilysin ) and/or HGF/SF *increased* the level of soluble [E-cadherin] and decreased the level of full-length ( M ( r ) 120,000 ) E-cadherin as detected by Western blotting . Positive_regulation CDH1 MMP7 12507936 1027460 The sum effect of MMP inhibitors demonstrated that NO-induced activation of may *cause* the degradation of [E-cadherin] and the subsequent dissociation of beta-catenin , thereby contributing to the cytosolic accumulation of beta-catenin and nuclear formation of beta-catenin/LEF-1 complex . Positive_regulation CDH1 MMP7 12759241 1091065 ( matrix metalloproteinase-7 ) *mediates* [E-cadherin] ectodomain shedding in injured lung epithelium . Positive_regulation CDH1 NEDD9 21765937 2456698 and BCAR1 negatively *regulate* [E-cadherin] membrane localization , and promote E-cadherin degradation . Positive_regulation CDH1 PCDH19 22193776 2543652 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH1 PCDH8 22193776 2543657 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH1 PECAM1 19714308 2127454 Significant radiation induced increase of ICAM-1 ( intercellular adhesion molecule-1 ) , VCAM-1 ( vascular cell adhesion molecule-1 ) , JAM-1 ( junctional adhesion molecule-1 ) , beta1-integrin , beta2-integrin , [E-cadherin] , and P-selectin gene expression could be *detected* in vivo , while ( platelet-endothelial cell adhesion molecule-1 ) gene expression remained unchanged . Positive_regulation CDH1 TF 17912456 1803857 differentially *regulated* [E-cadherin] and beta-catenin in these cells . Positive_regulation CDH1 TMPRSS4 17968309 1894490 Furthermore , overexpression of *induced* loss of [E-cadherin] mediated cell-cell adhesion , concomitant with the induction of SIP1/ZEB2 , an E-cadherin transcriptional repressor , and led to epithelial-mesenchymal transition events , including morphological changes , actin reorganization and upregulation of mesenchymal markers . Positive_regulation CDH1 TNF 11832448 910232 Activation of Src by *led* to reduced [E-cadherin] levels and enhanced invasion of src transfectants . Positive_regulation CDH1 TNF 12095140 960539 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH1 TNF 12503700 1026845 Dexamethasone inhibited the effect of and *induced* a three-fold increase in [E-cadherin] expression . Positive_regulation CDH1 TNF 23285692 2711877 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH1 WNT7A 12937339 1135342 *induces* [E-cadherin] in lung cancer cells . Positive_regulation CDH1 WNT7A 12937339 1135711 Here we show that both *activates* [E-cadherin] expression via a beta-catenin specific mechanism in lung cancer cells and is involved in a positive feedback loop . Positive_regulation CDH1 WNT7A 15705594 1402678 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDH1 WNT7A 16835228 1606478 SR 202 also reversed the increase in [E-cadherin] expression *mediated* by and Fzd 9 . Positive_regulation CDH1 WNT7A 21874048 2579378 Moreover , we found that [E-cadherin] expression in cancer cells may be positively *regulated* by , whose expression is negatively regulated by mesenchymal-specific DNA hypermethylation or ZEB1 in mesenchymal-like OSCC cells . Positive_regulation CDH10 PCDH19 22193776 2543663 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH10 PCDH8 22193776 2543668 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH10 TNF 12095140 960540 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH10 TNF 23285692 2711878 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH10 WNT7A 15705594 1402680 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDH11 PCDH19 22193776 2543674 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH11 PCDH8 22193776 2543679 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH11 TNF 12095140 960541 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH11 TNF 18821672 1970493 In vitro , [cadherin 11] expression by FLS was consistently *up-regulated* by at the protein , but not the messenger RNA , level . Positive_regulation CDH11 TNF 23285692 2711879 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH11 WNT7A 15705594 1402682 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDH12 PCDH19 22193776 2543685 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH12 PCDH8 22193776 2543690 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH12 TNF 12095140 960542 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH12 TNF 23285692 2711880 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH12 WNT7A 15705594 1402684 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDH13 FOXO1 21940942 2507179 Deacetylated inhibits free cholesterol induced Akt phosphorylation and *increases* levels of the nuclear factor-?B precursor [p105] , decreasing nuclear translocation of nuclear factor-?B p65 subunit and dampening mitogen activated protein/extracellular signal regulated kinase activation to prevent inflammation . Positive_regulation CDH13 MAP2K6 18270204 1891203 Similarly , directed EPRAP expression in RAW264.7 cells suppresses LPS induced [p105] phosphorylation and degradation , and subsequent *activation* of 1/2 . Positive_regulation CDH13 NEDD9 11297557 819952 Direct phosphorylation of NF-kappaB1 by the IkappaB kinase complex on serine 927 is *essential* for signal induced [p105] proteolysis . Positive_regulation CDH13 PCDH19 22193776 2543696 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH13 PCDH8 22193776 2543701 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH13 TLR7 17507094 1750996 Upon *stimulation* with ligands , [p105] is phosphorylated by I kappa B kinase (IKK) complex and partially degraded , which releases TPL2 . Positive_regulation CDH13 TNF 12095140 960543 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH13 TNF 12482991 1032859 In this study , *induced* [p105] proteolysis was revealed to additionally require the phosphorylation of serine 932 . Positive_regulation CDH13 TNF 12871932 1142277 Moreover , [p105] degradation in *response* to is prevented in GSK-3 beta-/- fibroblasts and by a Ser to Ala point mutation on p105 at positions 903 or 907 . Positive_regulation CDH13 TNF 23285692 2711881 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH13 TNF 7947998 277251 Our results indicate that both PAF and *stimulate* the expression of NF-kappa B [p50/p105] in vivo . Positive_regulation CDH13 WNT7A 15705594 1402686 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDH15 PCDH19 22193776 2543707 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH15 PCDH8 22193776 2543712 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH15 TNF 12095140 960544 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH15 TNF 23285692 2711882 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH15 WNT7A 15705594 1402688 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDH16 PCDH19 22193776 2543718 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH16 PCDH8 22193776 2543723 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH16 TNF 12095140 960545 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH16 TNF 23285692 2711883 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH16 WNT7A 15705594 1402690 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDH17 PCDH19 22193776 2543729 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH17 PCDH8 22193776 2543734 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH17 TNF 12095140 960546 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH17 TNF 23285692 2711884 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH17 WNT7A 15705594 1402692 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDH18 PCDH19 22193776 2543740 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH18 PCDH8 22193776 2543745 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH18 TNF 12095140 960547 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH18 TNF 23285692 2711885 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH18 WNT7A 15705594 1402694 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDH19 PCDH19 22193776 2543751 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH19 PCDH8 22193776 2543756 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH19 TNF 12095140 960548 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH19 TNF 23285692 2711886 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH19 WNT7A 15705594 1402696 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDH2 CAPN8 19420263 2075956 Calpain directly cleaved [N-cadherin] in in vitro calpain assays , and inhibitors *prevented* its cleavage in a dose dependent manner . Positive_regulation CDH2 CTGF 20117462 2202363 Rac1 induced *regulates* connexin 43 and [N-cadherin] expression in atrial fibrillation . Positive_regulation CDH2 MAP2K6 18252806 1895879 Last , TBP , inhibitor , or p38 inhibitor also *block* cell surface expression of [N-cadherin] , a marker of mesenchymal cells . Positive_regulation CDH2 MMP7 20139113 2265135 This study demonstrates that is *involved* in the cleavage of [N-cadherin] and modulates VSMC apoptosis , and may therefore contribute to plaque development and rupture . Positive_regulation CDH2 PCDH19 22193776 2543762 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH2 PCDH8 22193776 2543767 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH2 SLC6A2 20547485 2302040 Using small interfering RNAs , we found that , the guanine nucleotide exchange factor of RhoA , is *critical* for TGF-beta1 induced cytoskeletal reorganization , [N-cadherin] expression , and RhoA activation . Positive_regulation CDH2 TGM2 23290789 2764002 *induces* [N-cadherin] expression in TGF-ß1 induced epithelial mesenchymal transition via c-Jun-N-terminal kinase activation by protein phosphatase 2A down-regulation . Positive_regulation CDH2 TGM2 23290789 2764005 Suppression of Tgase-2 or the c-Jun-N-terminal kinase (JNK) inhibitor , SP600125 , significantly reduced and over-expression of *increased* the expression of [N-cadherin] . Positive_regulation CDH2 TGM2 23290789 2764010 These results suggested that *induces* [N-cadherin] expression of TGF-ß1 induced EMT via JNK activation by PP2A down-regulation , and Tgase-2/PP2A/JNK might be a novel axis that affects N-cadherin switching in the EMT of A549 lung cancer cells . Positive_regulation CDH2 TNF 12095140 960549 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH2 TNF 23285692 2711887 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH2 WNT7A 15705594 1402698 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDH20 PCDH19 22193776 2543773 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH20 PCDH8 22193776 2543778 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH20 TNF 12095140 960550 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH20 TNF 23285692 2711888 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH20 WNT7A 15705594 1402700 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDH22 PCDH19 22193776 2543608 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH22 PCDH8 22193776 2543613 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH22 TNF 12095140 960535 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH22 TNF 23285692 2711873 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH22 WNT7A 15705594 1402670 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDH23 PCDH19 22193776 2543619 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH23 PCDH8 22193776 2543624 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH23 TNF 12095140 960536 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH23 TNF 23285692 2711874 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH23 WNT7A 15705594 1402672 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDH24 PCDH19 22193776 2543630 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH24 PCDH8 22193776 2543635 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH24 TNF 12095140 960537 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH24 TNF 23285692 2711875 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH24 WNT7A 15705594 1402674 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDH26 PCDH19 22193776 2543641 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH26 PCDH8 22193776 2543646 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH26 TNF 12095140 960538 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH26 TNF 23285692 2711876 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH26 WNT7A 15705594 1402676 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDH3 PCDH19 22193776 2543784 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH3 PCDH8 22193776 2543789 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH3 TNF 12095140 960551 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH3 TNF 23285692 2711889 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH3 WNT7A 15705594 1402702 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDH4 PCDH19 22193776 2543795 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH4 PCDH8 22193776 2543800 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH4 TNF 12095140 960552 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH4 TNF 23285692 2711890 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH4 WNT7A 15705594 1402704 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDH5 CHI3L1 23665676 2926298 also *induced* the interaction of [vascular endothelial cadherin/ß-catenin/actin] in endothelial cells ( HMVECs ) . Positive_regulation CDH5 MMP28 15530852 1332809 Our data suggest that TIMP-1 inhibits HDMVEC migration through *dependent* stimulation of [VE-cadherin] and MMP independent stimulation of PTEN with subsequent dephosphorylation of FAK and cytoskeletal remodeling . Positive_regulation CDH5 MMP7 15530852 1332824 Our data suggest that TIMP-1 inhibits HDMVEC migration through *dependent* stimulation of [VE-cadherin] and MMP independent stimulation of PTEN with subsequent dephosphorylation of FAK and cytoskeletal remodeling . Positive_regulation CDH5 PCDH19 22193776 2543806 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH5 PCDH8 22193776 2543811 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH5 PECAM1 19281230 2063743 Furthermore , DEN-2 infection caused decreased expression and redistribution of both [VE-cadherin] and ZO-1 , whose changes were *enhanced* by engagement . Positive_regulation CDH5 TNF 12010652 941257 We investigated whether *regulates* the synthesis of [VE-cadherin] on the transcriptional level . Positive_regulation CDH5 TNF 12095140 960553 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH5 TNF 15271797 1322107 We found that *caused* tyrosine phosphorylation of [VE-cadherin] , separation of lateral cell-cell junctions , and intercellular gap formation in human umbilical vein endothelial cell ( HUVEC ) monolayers . Positive_regulation CDH5 TNF 15271797 1322112 Finally , adenoviral delivery of the kinase dead PAK1 ( K298A ) decreased *induced* JNK activation , [VE-cadherin] phosphorylation , and lateral junctional separation , consistent with the proposed involvement of PAK1 upstream of the NADPH oxidase . Positive_regulation CDH5 TNF 16039554 1437618 Furthermore , it was found that ESM attenuated the disorganization of [vascular endothelial (VE)-cadherin] *induced* by . Positive_regulation CDH5 TNF 16891393 1638886 PP2 also blocked *induced* tyrosine phosphorylation of [VE-cadherin] , gamma-catenin , and p120(ctn) . Positive_regulation CDH5 TNF 20308428 2230598 We find that depletion of p110alpha but not other p110 isoforms decreases *induced* endothelial permeability , Tyr phosphorylation of the adherens junction protein [vascular endothelial cadherin] ( VE-cadherin ) , and leukocyte TEM . Positive_regulation CDH5 TNF 23285692 2711891 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH5 WNT7A 15705594 1402706 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDH6 PCDH19 22193776 2543817 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH6 PCDH8 22193776 2543822 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH6 TNF 12095140 960554 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH6 TNF 23285692 2711892 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH6 WNT7A 15705594 1402708 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDH7 PCDH19 22193776 2543828 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH7 PCDH8 22193776 2543833 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH7 TNF 12095140 960555 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH7 TNF 23285692 2711893 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH7 WNT7A 15705594 1402710 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDH8 PCDH19 22193776 2543839 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH8 PCDH8 22193776 2543844 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH8 TNF 12095140 960556 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH8 TNF 23285692 2711894 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH8 WNT7A 15705594 1402712 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDH9 PCDH19 22193776 2543850 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH9 PCDH8 22193776 2543855 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Positive_regulation CDH9 TNF 12095140 960557 The purpose of our study was to determine the effect of TNFalpha on VE-cadherin cell-surface expression and to identify the signaling pathways involved in *induced* changes in [cadherin] expression . Positive_regulation CDH9 TNF 23285692 2711895 However , did not *cause* such a significant increase in [sE-cadherin] level . Positive_regulation CDH9 WNT7A 15705594 1402714 In NSCLC cells , and Fzd-9 *induced* both [cadherin] and Sprouty-4 expression and stimulated the JNK pathway , but not beta-catenin/T cell factor activity . Positive_regulation CDK1 CCND1 10437914 634625 overexpression in mouse epidermis *increases* [cyclin dependent kinase] activity and cell proliferation in vivo but does not affect skin tumor development . Positive_regulation CDK1 CCND1 10995875 733631 Inhibition of expression or *induction* of [cyclin dependent kinase] inhibitor p21WAF1 expression was found in mimosine treated lung cancer cells . Positive_regulation CDK1 CCND1 18845673 1988550 Analysis of cyclin and cdk mRNA and protein abundance revealed that CCK overexpression *increased* cyclin A , cyclin B , cyclin E , [cdk1] , and cdk2 with no change in , cyclin D2 , cyclin D3 , cdk4 , or cdk6 in mouse and human islets . Positive_regulation CDK1 CCND1 22001116 2522191 In contrast , ectopic overexpression of Clmn produces an increase in the [cyclin dependent kinase] *inhibitor* , p21 ( Cip1 ) , a decrease in protein and an increase in hypophosphorylated Rb , showing that Clmn participates in G ( 1 ) /S arrest . Positive_regulation CDK1 EPHB2 20664969 2298218 Immunoblot analysis demonstrated that oridonin treatment increased expression levels of p-JNK , p-p38 , p-p53 and p21 , elevated the level of cyclin [B1/p-Cdc2] ( Tyr15 ) complex , and *inhibited* the expression of . Positive_regulation CDK1 EPHB2 20855497 2325844 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Positive_regulation CDK1 FAS 17351056 1733954 Loss of *results* in reduced type A [cyclin dependent kinase] activity , inhibits mitotic progression , and promotes a precocious and systemic switch to the endocycle program . Positive_regulation CDK1 FAS 20937773 2347747 [Cdk1/cyclin] B1 controls *mediated* apoptosis by regulating caspase-8 activity . Positive_regulation CDK1 FOXO1 18356527 1887679 *Activation* of by [Cdk1] in cycling cells and postmitotic neurons . Positive_regulation CDK1 FOXO1 18356527 1887681 In proliferating cells , [Cdk1] *induced* Ser249 phosphorylation at the G2/M phase of the cell cycle , resulting in FOXO1 dependent expression of the mitotic regulator Polo-like kinase (Plk) . Positive_regulation CDK1 ID1 23342268 2712723 We propose that increased and Id3 expression *attenuates* all three [cyclin dependent kinase] inhibitors ( CDKN2B , -1A , and -1B ) resulting in a more aggressive PCa phenotype . Positive_regulation CDK1 MAP2K6 10712507 674084 In oocytes , the activation of Mos , , and p42 MAPK is *required* for progesterone induced [Cdc2] activation , and activated forms of any of these proteins can bring about Cdc2 activation in the absence of progesterone . Positive_regulation CDK1 MAP2K6 9450967 484051 In other experiments , p42MAPK activation by MEK or by Mos inhibited [Cdc2] activation by cyclin B. PD098059 , a specific inhibitor of , *blocked* the effects of MEK ( QP ) and Mos . Positive_regulation CDK1 MIP 17098733 1676147 *regulates* the expression of B-Myb and the induction of cyclin A , cyclin B , and [CDK1] . Positive_regulation CDK1 TNF 10657902 664273 *promotes* human papillomavirus ( HPV ) E6/E7 RNA expression and [cyclin dependent kinase] activity in HPV immortalized keratinocytes by a ras dependent pathway . Positive_regulation CDK1 TNF 15723438 1376703 Demonstration was also provided that EGF alone only promoted cell progression up to late G ( 1 ) , whereas was *necessary* for G ( 1 ) /S transition and [Cdk1] induction . Positive_regulation CDK1 TNF 8262134 239136 We observed that *induced* [CDC2] and CDK2 expression in early-passage quiescent WI-38 fibroblasts . Positive_regulation CDK1 TNF 8262134 239138 However , as cells approached senescence , their ability to induce [CDC2] and CDK2 , as well as stimulate DNA synthesis in *response* to , progressively declined , with minimal to absent induction in senescent cells . Positive_regulation CDK1 TNF 8262134 239142 These results demonstrate that senescent cells are selectively deficient in *mediated* induction of [CDC2] and CDK2 , genes crucial to DNA synthesis and mitosis . Positive_regulation CDK10 CCND1 10437914 634627 overexpression in mouse epidermis *increases* [cyclin dependent kinase] activity and cell proliferation in vivo but does not affect skin tumor development . Positive_regulation CDK10 CCND1 10995875 733633 Inhibition of expression or *induction* of [cyclin dependent kinase] inhibitor p21WAF1 expression was found in mimosine treated lung cancer cells . Positive_regulation CDK10 CCND1 22001116 2522195 In contrast , ectopic overexpression of Clmn produces an increase in the [cyclin dependent kinase] *inhibitor* , p21 ( Cip1 ) , a decrease in protein and an increase in hypophosphorylated Rb , showing that Clmn participates in G ( 1 ) /S arrest . Positive_regulation CDK10 EPHB2 20855497 2325847 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Positive_regulation CDK10 FAS 17351056 1733956 Loss of *results* in reduced type A [cyclin dependent kinase] activity , inhibits mitotic progression , and promotes a precocious and systemic switch to the endocycle program . Positive_regulation CDK10 ID1 23342268 2712727 We propose that increased and Id3 expression *attenuates* all three [cyclin dependent kinase] inhibitors ( CDKN2B , -1A , and -1B ) resulting in a more aggressive PCa phenotype . Positive_regulation CDK10 TNF 10657902 664275 *promotes* human papillomavirus ( HPV ) E6/E7 RNA expression and [cyclin dependent kinase] activity in HPV immortalized keratinocytes by a ras dependent pathway . Positive_regulation CDK12 CCND1 10437914 634638 overexpression in mouse epidermis *increases* [cyclin dependent kinase] activity and cell proliferation in vivo but does not affect skin tumor development . Positive_regulation CDK12 CCND1 10995875 733645 Inhibition of expression or *induction* of [cyclin dependent kinase] inhibitor p21WAF1 expression was found in mimosine treated lung cancer cells . Positive_regulation CDK12 CCND1 22001116 2522219 In contrast , ectopic overexpression of Clmn produces an increase in the [cyclin dependent kinase] *inhibitor* , p21 ( Cip1 ) , a decrease in protein and an increase in hypophosphorylated Rb , showing that Clmn participates in G ( 1 ) /S arrest . Positive_regulation CDK12 EPHB2 20855497 2325859 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Positive_regulation CDK12 FAS 17351056 1733967 Loss of *results* in reduced type A [cyclin dependent kinase] activity , inhibits mitotic progression , and promotes a precocious and systemic switch to the endocycle program . Positive_regulation CDK12 ID1 23342268 2712749 We propose that increased and Id3 expression *attenuates* all three [cyclin dependent kinase] inhibitors ( CDKN2B , -1A , and -1B ) resulting in a more aggressive PCa phenotype . Positive_regulation CDK12 TNF 10657902 664286 *promotes* human papillomavirus ( HPV ) E6/E7 RNA expression and [cyclin dependent kinase] activity in HPV immortalized keratinocytes by a ras dependent pathway . Positive_regulation CDK13 CCND1 10437914 634626 overexpression in mouse epidermis *increases* [cyclin dependent kinase] activity and cell proliferation in vivo but does not affect skin tumor development . Positive_regulation CDK13 CCND1 10995875 733632 Inhibition of expression or *induction* of [cyclin dependent kinase] inhibitor p21WAF1 expression was found in mimosine treated lung cancer cells . Positive_regulation CDK13 CCND1 22001116 2522193 In contrast , ectopic overexpression of Clmn produces an increase in the [cyclin dependent kinase] *inhibitor* , p21 ( Cip1 ) , a decrease in protein and an increase in hypophosphorylated Rb , showing that Clmn participates in G ( 1 ) /S arrest . Positive_regulation CDK13 EPHB2 20855497 2325845 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Positive_regulation CDK13 FAS 17351056 1733955 Loss of *results* in reduced type A [cyclin dependent kinase] activity , inhibits mitotic progression , and promotes a precocious and systemic switch to the endocycle program . Positive_regulation CDK13 ID1 23342268 2712725 We propose that increased and Id3 expression *attenuates* all three [cyclin dependent kinase] inhibitors ( CDKN2B , -1A , and -1B ) resulting in a more aggressive PCa phenotype . Positive_regulation CDK13 TNF 10657902 664274 *promotes* human papillomavirus ( HPV ) E6/E7 RNA expression and [cyclin dependent kinase] activity in HPV immortalized keratinocytes by a ras dependent pathway . Positive_regulation CDK14 CCND1 10437914 634642 overexpression in mouse epidermis *increases* [cyclin dependent kinase] activity and cell proliferation in vivo but does not affect skin tumor development . Positive_regulation CDK14 CCND1 10995875 733649 Inhibition of expression or *induction* of [cyclin dependent kinase] inhibitor p21WAF1 expression was found in mimosine treated lung cancer cells . Positive_regulation CDK14 CCND1 22001116 2522227 In contrast , ectopic overexpression of Clmn produces an increase in the [cyclin dependent kinase] *inhibitor* , p21 ( Cip1 ) , a decrease in protein and an increase in hypophosphorylated Rb , showing that Clmn participates in G ( 1 ) /S arrest . Positive_regulation CDK14 EPHB2 20855497 2325863 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Positive_regulation CDK14 FAS 17351056 1733971 Loss of *results* in reduced type A [cyclin dependent kinase] activity , inhibits mitotic progression , and promotes a precocious and systemic switch to the endocycle program . Positive_regulation CDK14 ID1 23342268 2712757 We propose that increased and Id3 expression *attenuates* all three [cyclin dependent kinase] inhibitors ( CDKN2B , -1A , and -1B ) resulting in a more aggressive PCa phenotype . Positive_regulation CDK14 TNF 10657902 664290 *promotes* human papillomavirus ( HPV ) E6/E7 RNA expression and [cyclin dependent kinase] activity in HPV immortalized keratinocytes by a ras dependent pathway . Positive_regulation CDK15 CCND1 10437914 634624 overexpression in mouse epidermis *increases* [cyclin dependent kinase] activity and cell proliferation in vivo but does not affect skin tumor development . Positive_regulation CDK15 CCND1 10995875 733630 Inhibition of expression or *induction* of [cyclin dependent kinase] inhibitor p21WAF1 expression was found in mimosine treated lung cancer cells . Positive_regulation CDK15 CCND1 22001116 2522188 In contrast , ectopic overexpression of Clmn produces an increase in the [cyclin dependent kinase] *inhibitor* , p21 ( Cip1 ) , a decrease in protein and an increase in hypophosphorylated Rb , showing that Clmn participates in G ( 1 ) /S arrest . Positive_regulation CDK15 EPHB2 20855497 2325843 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Positive_regulation CDK15 FAS 17351056 1733953 Loss of *results* in reduced type A [cyclin dependent kinase] activity , inhibits mitotic progression , and promotes a precocious and systemic switch to the endocycle program . Positive_regulation CDK15 ID1 23342268 2712721 We propose that increased and Id3 expression *attenuates* all three [cyclin dependent kinase] inhibitors ( CDKN2B , -1A , and -1B ) resulting in a more aggressive PCa phenotype . Positive_regulation CDK15 TNF 10657902 664272 *promotes* human papillomavirus ( HPV ) E6/E7 RNA expression and [cyclin dependent kinase] activity in HPV immortalized keratinocytes by a ras dependent pathway . Positive_regulation CDK16 CCND1 10437914 634639 overexpression in mouse epidermis *increases* [cyclin dependent kinase] activity and cell proliferation in vivo but does not affect skin tumor development . Positive_regulation CDK16 CCND1 10995875 733646 Inhibition of expression or *induction* of [cyclin dependent kinase] inhibitor p21WAF1 expression was found in mimosine treated lung cancer cells . Positive_regulation CDK16 CCND1 22001116 2522221 In contrast , ectopic overexpression of Clmn produces an increase in the [cyclin dependent kinase] *inhibitor* , p21 ( Cip1 ) , a decrease in protein and an increase in hypophosphorylated Rb , showing that Clmn participates in G ( 1 ) /S arrest . Positive_regulation CDK16 EPHB2 20855497 2325860 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Positive_regulation CDK16 FAS 17351056 1733968 Loss of *results* in reduced type A [cyclin dependent kinase] activity , inhibits mitotic progression , and promotes a precocious and systemic switch to the endocycle program . Positive_regulation CDK16 ID1 23342268 2712751 We propose that increased and Id3 expression *attenuates* all three [cyclin dependent kinase] inhibitors ( CDKN2B , -1A , and -1B ) resulting in a more aggressive PCa phenotype . Positive_regulation CDK16 TNF 10657902 664287 *promotes* human papillomavirus ( HPV ) E6/E7 RNA expression and [cyclin dependent kinase] activity in HPV immortalized keratinocytes by a ras dependent pathway . Positive_regulation CDK17 CCND1 10437914 634640 overexpression in mouse epidermis *increases* [cyclin dependent kinase] activity and cell proliferation in vivo but does not affect skin tumor development . Positive_regulation CDK17 CCND1 10995875 733647 Inhibition of expression or *induction* of [cyclin dependent kinase] inhibitor p21WAF1 expression was found in mimosine treated lung cancer cells . Positive_regulation CDK17 CCND1 22001116 2522223 In contrast , ectopic overexpression of Clmn produces an increase in the [cyclin dependent kinase] *inhibitor* , p21 ( Cip1 ) , a decrease in protein and an increase in hypophosphorylated Rb , showing that Clmn participates in G ( 1 ) /S arrest . Positive_regulation CDK17 EPHB2 20855497 2325861 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Positive_regulation CDK17 FAS 17351056 1733969 Loss of *results* in reduced type A [cyclin dependent kinase] activity , inhibits mitotic progression , and promotes a precocious and systemic switch to the endocycle program . Positive_regulation CDK17 ID1 23342268 2712753 We propose that increased and Id3 expression *attenuates* all three [cyclin dependent kinase] inhibitors ( CDKN2B , -1A , and -1B ) resulting in a more aggressive PCa phenotype . Positive_regulation CDK17 TNF 10657902 664288 *promotes* human papillomavirus ( HPV ) E6/E7 RNA expression and [cyclin dependent kinase] activity in HPV immortalized keratinocytes by a ras dependent pathway . Positive_regulation CDK18 CCND1 10437914 634641 overexpression in mouse epidermis *increases* [cyclin dependent kinase] activity and cell proliferation in vivo but does not affect skin tumor development . Positive_regulation CDK18 CCND1 10995875 733648 Inhibition of expression or *induction* of [cyclin dependent kinase] inhibitor p21WAF1 expression was found in mimosine treated lung cancer cells . Positive_regulation CDK18 CCND1 22001116 2522225 In contrast , ectopic overexpression of Clmn produces an increase in the [cyclin dependent kinase] *inhibitor* , p21 ( Cip1 ) , a decrease in protein and an increase in hypophosphorylated Rb , showing that Clmn participates in G ( 1 ) /S arrest . Positive_regulation CDK18 EPHB2 20855497 2325862 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Positive_regulation CDK18 FAS 17351056 1733970 Loss of *results* in reduced type A [cyclin dependent kinase] activity , inhibits mitotic progression , and promotes a precocious and systemic switch to the endocycle program . Positive_regulation CDK18 ID1 23342268 2712755 We propose that increased and Id3 expression *attenuates* all three [cyclin dependent kinase] inhibitors ( CDKN2B , -1A , and -1B ) resulting in a more aggressive PCa phenotype . Positive_regulation CDK18 TNF 10657902 664289 *promotes* human papillomavirus ( HPV ) E6/E7 RNA expression and [cyclin dependent kinase] activity in HPV immortalized keratinocytes by a ras dependent pathway . Positive_regulation CDK19 ANGPT1 12890486 1117470 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation CDK19 ANGPT1 16638932 1589728 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation CDK19 CCND1 10437914 634636 overexpression in mouse epidermis *increases* [cyclin dependent kinase] activity and cell proliferation in vivo but does not affect skin tumor development . Positive_regulation CDK19 CCND1 10995875 733643 Inhibition of expression or *induction* of [cyclin dependent kinase] inhibitor p21WAF1 expression was found in mimosine treated lung cancer cells . Positive_regulation CDK19 CCND1 22001116 2522215 In contrast , ectopic overexpression of Clmn produces an increase in the [cyclin dependent kinase] *inhibitor* , p21 ( Cip1 ) , a decrease in protein and an increase in hypophosphorylated Rb , showing that Clmn participates in G ( 1 ) /S arrest . Positive_regulation CDK19 CD14 16574244 1582644 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation CDK19 CHI3L1 18802121 1965027 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation CDK19 EDN2 7693285 231262 *induced* contraction and [mediator] release in human bronchus . Positive_regulation CDK19 EDN2 9124581 424065 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation CDK19 EPHB2 20138154 2227078 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation CDK19 EPHB2 20855497 2325857 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Positive_regulation CDK19 EPHB2 23684917 2796492 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation CDK19 FAS 17351056 1733965 Loss of *results* in reduced type A [cyclin dependent kinase] activity , inhibits mitotic progression , and promotes a precocious and systemic switch to the endocycle program . Positive_regulation CDK19 ID1 11278321 798185 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation CDK19 ID1 23342268 2712745 We propose that increased and Id3 expression *attenuates* all three [cyclin dependent kinase] inhibitors ( CDKN2B , -1A , and -1B ) resulting in a more aggressive PCa phenotype . Positive_regulation CDK19 IL1B 9810029 545622 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation CDK19 ITGB2 9152024 430917 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation CDK19 LBP 16574244 1582645 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation CDK19 TLR7 19631980 2131845 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation CDK19 TNF 10657902 664284 *promotes* human papillomavirus ( HPV ) E6/E7 RNA expression and [cyclin dependent kinase] activity in HPV immortalized keratinocytes by a ras dependent pathway . Positive_regulation CDK19 TNF 11159885 781424 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation CDK19 TNF 12524657 1047954 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation CDK19 TNF 14550746 1152730 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation CDK19 TNF 14982858 1214532 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation CDK19 TNF 17307735 1719091 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation CDK19 TNF 17988550 1821510 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation CDK19 TNF 18675993 2011438 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation CDK19 TNF 21904602 2478313 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation CDK19 TNF 23684917 2796491 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation CDK19 TNF 2788206 116808 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation CDK19 TNF 3292408 94751 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation CDK19 TNF 8453746 215224 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation CDK19 TNF 8679220 372477 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation CDK2 CCND1 10437914 634628 overexpression in mouse epidermis *increases* [cyclin dependent kinase] activity and cell proliferation in vivo but does not affect skin tumor development . Positive_regulation CDK2 CCND1 10600818 574082 Thus appears to play two roles during G ( 1 ) phase progression in the regenerating liver : it forms a nuclear kinase complex , and it *promotes* activation of [Cdk2] by sequestering inhibitory proteins such as p27 . Positive_regulation CDK2 CCND1 10995875 733634 Inhibition of expression or *induction* of [cyclin dependent kinase] inhibitor p21WAF1 expression was found in mimosine treated lung cancer cells . Positive_regulation CDK2 CCND1 11114718 759175 The kinase activities of cyclin D/CDK4 , 6 and cyclin E/CDK2 complexes were only slightly elevated , consistent with the findings that coordinate increases in p21 , and cyclin E *resulted* in an increase in [cyclin/CDK/p21] complexes . Positive_regulation CDK2 CCND1 12401786 1025520 Our data also demonstrate that ectopic overexpression of either cyclin is sufficient to induce mitogen independent growth in human T98G and Rat-1 cells , although the effects of *require* downstream activation of cyclin [E-CDK2] activity . Positive_regulation CDK2 CCND1 12432268 1015574 accumulates and *activates* its cognate [CDK] ( CDK4/6 ) in response to mitogenic growth factors in early to mid G ( 1 ) phase . Positive_regulation CDK2 CCND1 15316112 1290549 The expression of *led* to the early activation of total [CDK] activity , consistent with accelerated cell cycle progression . Positive_regulation CDK2 CCND1 17635516 1770595 Ectopic expression of alone was not *sufficient* to induce CDK4 nuclear translocation , [CDK2] activity or cell proliferation . Positive_regulation CDK2 CCND1 17699765 1782840 is a multifunctional , tumor associated protein that interacts with pRb via a conserved LxCxE motif , activates a kinase partner , directs the phosphorylation of pRb , *activates* cyclin [E-cyclin dependent kinase 2 (cdk2)] by titrating Cip/Kip cdk inhibitors , and modulates the activity of a variety of transcription factors . Positive_regulation CDK2 CCND1 22001116 2522197 In contrast , ectopic overexpression of Clmn produces an increase in the [cyclin dependent kinase] *inhibitor* , p21 ( Cip1 ) , a decrease in protein and an increase in hypophosphorylated Rb , showing that Clmn participates in G ( 1 ) /S arrest . Positive_regulation CDK2 CCND1 22771367 2676457 We found that TS extracts ( 10-75 µg/mL ) arrested HL-60 cells at the G1-S transition phase through the reductions of , CDK4 , Cyclin E , CDK2 , and Cyclin A , and *induction* of [CDK] inhibitor p27KIP levels . Positive_regulation CDK2 CCND1 23321641 2769678 Constitutive [Cdk2] *activation* through generates tumors in mice that are aneuploid and have many characteristics indicative of chromosomal instability . Positive_regulation CDK2 CCND1 23390492 2739703 Accumulation or over-expression of cyclin D1 (CCND1) occurs in a majority of breast cancers and over-expression of *leads* to accumulation of activated [CCND1/CDK2] complexes in breast cancer cells . Positive_regulation CDK2 CCND1 8867812 389143 Inducible expression of in T-47D human breast cancer cells is *sufficient* for [Cdk2] activation and pRB hyperphosphorylation . Positive_regulation CDK2 CCND1 8867812 389144 In mitogen stimulated cells induction in early G1 is *followed* by induction of cyclin E , activation of the cyclin dependent kinase [Cdk2] , and hyperphosphorylation of the retinoblastoma gene product ( pRB ) in mid-to-late G1 phase . Positive_regulation CDK2 CCND1 8867812 389148 T-47D breast cancer cells expressing cyclin D1 under the control of a metal-responsive metallothionein promoter were used to determine whether [Cdk2] activation and pRB hyperphosphorylation are *consequences* of induction . Positive_regulation CDK2 CCND1 8867812 389152 These data show that induction is *sufficient* for [Cdk2] activation and pRB hyperphosphorylation in T-47D human breast cancer cells , providing evidence that cyclin D1 induction is a critical event in G1 phase progression . Positive_regulation CDK2 CCND1 9169494 432868 overexpression *resulted* in a concomitant increase in CDK4 levels in the adult myocardium , as well as modest increases in proliferating cell nuclear antigen and [CDK2] levels . Positive_regulation CDK2 CCND1 9244353 446260 We demonstrate that both and CDK4 functionally depend on active Myc to exert their potential as oncogenes and vice versa that the transforming ability of Myc *requires* functional cyclin [D/CDK] complexes . Positive_regulation CDK2 CCND1 9671459 519901 c-Myc expression was not accompanied by increased cyclin D1 expression or Cdk4 activation , nor was cyclin D1 induction accompanied by increases in c-Myc. Expression of c-Myc or was *sufficient* to activate cyclin [E-Cdk2] by promoting the formation of high-molecular-weight complexes lacking the cyclin dependent kinase inhibitor p21 , as has been described , following estrogen treatment . Positive_regulation CDK2 CDKN1C 10551775 565258 Selective expression by the tetracycline analog doxycycline to levels comparable to those observed on DEX induction *resulted* in a 1.7-fold increase in the doubling time and a shift of HeLa cells to the G1 phase as well as a decrease in [CDK2] activity . Positive_regulation CDK2 CDKN1C 11880488 919418 Pituitary adenylate cyclase activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is regulated by *dependent* [CDK2] activity . Positive_regulation CDK2 CDKN1C 11880488 919459 We now report that the endogenous peptide , pituitary adenylate cyclase activating polypeptide ( PACAP ) , negatively regulates the cell cycle by inhibiting *dependent* [CDK2] activity in embryonic cortex . Positive_regulation CDK2 EPHB2 17893107 1823879 The map kinase *regulates* renal activity of [cyclin dependent kinase 2] in experimental glomerulonephritis . Positive_regulation CDK2 EPHB2 17893107 1823882 In stimulated MC , inhibition of *reduced* cyclin dependent kinase 2 (CDK2) phosphorylation , [CDK2] activity and cyclin E/A expression , whereas downregulation of CDK inhibitor p27 ( Kip1 ) expression was inhibited . Positive_regulation CDK2 EPHB2 20855497 2325848 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Positive_regulation CDK2 FAS 17351056 1733957 Loss of *results* in reduced type A [cyclin dependent kinase] activity , inhibits mitotic progression , and promotes a precocious and systemic switch to the endocycle program . Positive_regulation CDK2 FOXO1 17457058 1730247 Thus , [CDK2] silencing dependent *activation* of represents a new mechanism that links DNA strand breakage to cell death . Positive_regulation CDK2 ID1 12203366 983162 Ectopic expression in CNE1 cells *resulted* in an increase in serum independent cell growth , percentage of cells in S phase , and phosphorylation of RB and [cyclin dependent kinase 2] proteins . Positive_regulation CDK2 ID1 23342268 2712729 We propose that increased and Id3 expression *attenuates* all three [cyclin dependent kinase] inhibitors ( CDKN2B , -1A , and -1B ) resulting in a more aggressive PCa phenotype . Positive_regulation CDK2 IFI27 10896783 711676 Evaluation of the kinase activity of cyclin-Cdk complexes showed that RA increases ( Kip1 ) expression in CH27 cells *leading* to markedly reduced cyclin [A/Cdk2] kinase activity and slightly reduced cyclin E/Cdk2 kinase activity , with no effect on cyclin D/Cdk4 and cyclin D/Cdk6 activities . Positive_regulation CDK2 IFI27 11593401 869821 We addressed whether down regulation was *required* to activate cyclin D1/CDK4/6 or [cyclin E/CDK2] by engineering cells with inducible p27 . Positive_regulation CDK2 IFI27 16303599 1485512 Recent studies have shown that PGI2 dependent activation of its receptor , IP , inhibits G1 phase progression by blocking the degradation of and the *activation* of [cyclin E-cdk2] . Positive_regulation CDK2 IFI27 21312237 2398671 WIN 55,212-2 also upregulated phospho-ERK1/2 , *induced* and Cip1/WAF1/p21 expression , decreased cyclin D1 and cyclin E expression , decreased [Cdk 2] , Cdk 4 , and Cdk 6 expression levels , and decreased phospho-Rb and E2F-1 expression . Positive_regulation CDK2 IFI27 22584582 2614290 During the G ( 1 ) -S transition , the activity of [Cdk2] is *regulated* by its association with ( KIP1 ) , which in rodent fibroblasts undergoes phosphorylation mainly at serine 10 , threonine 187 , and C-terminal threonine 197 by KIS , Cdk2 , and Pim or ROCK , respectively . Positive_regulation CDK2 IFI27 23071750 2690011 *regulates* the activity of [Cdk] complexes which are the principal governors of phase transitions during cell division . Positive_regulation CDK2 IL1B 12171790 974225 Consistent with this hypothesis is the finding that [CDK2] activity , induced by PDGF-BB , is enhanced 2.3+/-0.2-fold in the *presence* of . Positive_regulation CDK2 IL1B 17454300 1730134 In contrast to cyclin D1 , *triggered* down-regulation of the [CDK] inhibitor , p21 . Positive_regulation CDK2 TNF 10657902 664276 *promotes* human papillomavirus ( HPV ) E6/E7 RNA expression and [cyclin dependent kinase] activity in HPV immortalized keratinocytes by a ras dependent pathway . Positive_regulation CDK2 TNF 10657902 664291 promoted cell cycle progression by increasing expression of HPV-16 E6/E7 RNAs and enhancing activity of [cyclin dependent kinase (cdk)2] and cdc2 after 3 d. Increased kinase activity was *mediated* by upregulation of cyclins A and B and decreases in cdk inhibitors p21 ( waf ) and p27 ( kip ) . Positive_regulation CDK2 TNF 12761882 1091733 We show that *induces* p21 ( waf1 ) protein in malignant melanoma A375 cells and its binding to [CDK2/4] and 6 proteins , and thereby inhibiting the activity of these complexes . Positive_regulation CDK2 TNF 22268651 2559828 *induced* the expression of [CDK2/CDK4] , and reduced the expression of p21 ( waf1/cip1 ) /p27 ( kip1 ) . Positive_regulation CDK2 TNF 8262134 239137 We observed that *induced* CDC2 and [CDK2] expression in early-passage quiescent WI-38 fibroblasts . Positive_regulation CDK2 TNF 8262134 239139 However , as cells approached senescence , their ability to induce CDC2 and [CDK2] , as well as stimulate DNA synthesis in *response* to , progressively declined , with minimal to absent induction in senescent cells . Positive_regulation CDK2 TNF 8262134 239143 These results demonstrate that senescent cells are selectively deficient in mediated *induction* of CDC2 and [CDK2] , genes crucial to DNA synthesis and mitosis . Positive_regulation CDK20 CCND1 10437914 634637 overexpression in mouse epidermis *increases* [cyclin dependent kinase] activity and cell proliferation in vivo but does not affect skin tumor development . Positive_regulation CDK20 CCND1 10995875 733644 Inhibition of expression or *induction* of [cyclin dependent kinase] inhibitor p21WAF1 expression was found in mimosine treated lung cancer cells . Positive_regulation CDK20 CCND1 22001116 2522217 In contrast , ectopic overexpression of Clmn produces an increase in the [cyclin dependent kinase] *inhibitor* , p21 ( Cip1 ) , a decrease in protein and an increase in hypophosphorylated Rb , showing that Clmn participates in G ( 1 ) /S arrest . Positive_regulation CDK20 EPHB2 20855497 2325858 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Positive_regulation CDK20 FAS 17351056 1733966 Loss of *results* in reduced type A [cyclin dependent kinase] activity , inhibits mitotic progression , and promotes a precocious and systemic switch to the endocycle program . Positive_regulation CDK20 ID1 23342268 2712747 We propose that increased and Id3 expression *attenuates* all three [cyclin dependent kinase] inhibitors ( CDKN2B , -1A , and -1B ) resulting in a more aggressive PCa phenotype . Positive_regulation CDK20 TNF 10657902 664285 *promotes* human papillomavirus ( HPV ) E6/E7 RNA expression and [cyclin dependent kinase] activity in HPV immortalized keratinocytes by a ras dependent pathway . Positive_regulation CDK3 CCND1 10437914 634629 overexpression in mouse epidermis *increases* [cyclin dependent kinase] activity and cell proliferation in vivo but does not affect skin tumor development . Positive_regulation CDK3 CCND1 10995875 733635 Inhibition of expression or *induction* of [cyclin dependent kinase] inhibitor p21WAF1 expression was found in mimosine treated lung cancer cells . Positive_regulation CDK3 CCND1 22001116 2522199 In contrast , ectopic overexpression of Clmn produces an increase in the [cyclin dependent kinase] *inhibitor* , p21 ( Cip1 ) , a decrease in protein and an increase in hypophosphorylated Rb , showing that Clmn participates in G ( 1 ) /S arrest . Positive_regulation CDK3 EPHB2 20855497 2325849 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Positive_regulation CDK3 FAS 17351056 1733958 Loss of *results* in reduced type A [cyclin dependent kinase] activity , inhibits mitotic progression , and promotes a precocious and systemic switch to the endocycle program . Positive_regulation CDK3 ID1 23342268 2712731 We propose that increased and Id3 expression *attenuates* all three [cyclin dependent kinase] inhibitors ( CDKN2B , -1A , and -1B ) resulting in a more aggressive PCa phenotype . Positive_regulation CDK3 TNF 10657902 664277 *promotes* human papillomavirus ( HPV ) E6/E7 RNA expression and [cyclin dependent kinase] activity in HPV immortalized keratinocytes by a ras dependent pathway . Positive_regulation CDK4 CCND1 10437914 634630 overexpression in mouse epidermis *increases* [cyclin dependent kinase] activity and cell proliferation in vivo but does not affect skin tumor development . Positive_regulation CDK4 CCND1 10625738 658956 and [Cdk4] protein *induction* in motor neurons after transient spinal cord ischemia in rabbits . Positive_regulation CDK4 CCND1 10995875 733636 Inhibition of expression or *induction* of [cyclin dependent kinase] inhibitor p21WAF1 expression was found in mimosine treated lung cancer cells . Positive_regulation CDK4 CCND1 11337496 827614 However , these treatments increased , cyclin E , and p21 gene expression and *induced* the formation of active [Cdk4] complexes but resulted in only minor increases in cyclin E-Cdk2 activity , likely due to recruitment of the cyclin dependent kinase (CDK) inhibitor p21 ( WAF1/Cip1 ) into these complexes . Positive_regulation CDK4 CCND1 12201056 982994 The protein level of [Cdk4] did not change , but MF *induced* a decreased expression of after 24 h and 30 h exposures . Positive_regulation CDK4 CCND1 12401721 1009338 Whole-kidney and glomerular hypertrophy caused by hyperglycemia was associated with specific G1 phase cell-cycle events : early and sustained increase in expression of and *activation* of [cyclin D1-cdk4] complexes , but no change in expression of cyclin E or cdk2 activity . Positive_regulation CDK4 CCND1 12811822 1102919 On the other hand , EPA inhibited [cyclin dependent kinase 4 (CDK4)] activation and protein *induction* , a critical step for G1/S progression . Positive_regulation CDK4 CCND1 14710852 1181384 Over-expression of *regulates* [Cdk4] protein synthesis . Positive_regulation CDK4 CCND1 16288002 1481168 Although binds and *activates* [cyclin dependent kinase 4 (Cdk4)] , thereby mediating activation of a program of E2F dependent gene expression , it has been suggested that the oncogenic activities of cyclin D1 are independent of Cdk4 . Positive_regulation CDK4 CCND1 17635516 1770596 Ectopic expression of alone was not *sufficient* to induce [CDK4] nuclear translocation , CDK2 activity or cell proliferation . Positive_regulation CDK4 CCND1 22001116 2522201 In contrast , ectopic overexpression of Clmn produces an increase in the [cyclin dependent kinase] *inhibitor* , p21 ( Cip1 ) , a decrease in protein and an increase in hypophosphorylated Rb , showing that Clmn participates in G ( 1 ) /S arrest . Positive_regulation CDK4 CCND1 9169494 432869 overexpression *resulted* in a concomitant increase in [CDK4] levels in the adult myocardium , as well as modest increases in proliferating cell nuclear antigen and CDK2 levels . Positive_regulation CDK4 CCND1 9603954 507063 The overall effect of rapamycin on *leads* , in turn , to impaired formation of active complexes with [Cdk4] , a process which triggers retargeting of the p27 ( Kip1 ) inhibitor to cyclin E/Cdk2 . Positive_regulation CDK4 CCND1 9815758 479565 Despite the continued presence of antiestrogen , induction *resulted* in the formation of active cyclin [D1/Cdk4] complexes , concurrent hyperphosphorylation of the retinoblastoma protein , and entry into S phase of cells previously arrested in G1 . Positive_regulation CDK4 EPHB2 11159909 781455 Activation of Ras and *causes* induction of cyclin [D1-Cdk4] without increase of cyclin E or PCNA in ductal lesions . Positive_regulation CDK4 EPHB2 20855497 2325850 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Positive_regulation CDK4 EPHB2 22214150 2519149 It was found that and JNK were *involved* in silica induced cyclin D1 and [CDK4] overexpression and the decreased expression of E2F-4 . Positive_regulation CDK4 FAS 17351056 1733959 Loss of *results* in reduced type A [cyclin dependent kinase] activity , inhibits mitotic progression , and promotes a precocious and systemic switch to the endocycle program . Positive_regulation CDK4 ID1 23342268 2712733 We propose that increased and Id3 expression *attenuates* all three [cyclin dependent kinase] inhibitors ( CDKN2B , -1A , and -1B ) resulting in a more aggressive PCa phenotype . Positive_regulation CDK4 IFI27 11593401 869822 We addressed whether down regulation was *required* to activate cyclin [D1/CDK4/6] or cyclin E/CDK2 by engineering cells with inducible p27 . Positive_regulation CDK4 IFI27 18710949 1968227 Thus , while PKB dependent p27 phosphorylation appears to increase cyclin D1-Cdk4-p27 assembly or stabilize these complexes in vitro , cyclin [D1-Cdk4-p27] activation *requires* the tyrosine phosphorylation of . Positive_regulation CDK4 IFI27 21312237 2398675 WIN 55,212-2 also upregulated phospho-ERK1/2 , *induced* and Cip1/WAF1/p21 expression , decreased cyclin D1 and cyclin E expression , decreased Cdk 2 , [Cdk 4] , and Cdk 6 expression levels , and decreased phospho-Rb and E2F-1 expression . Positive_regulation CDK4 TNF 10657902 664278 *promotes* human papillomavirus ( HPV ) E6/E7 RNA expression and [cyclin dependent kinase] activity in HPV immortalized keratinocytes by a ras dependent pathway . Positive_regulation CDK4 TNF 22268651 2559829 *induced* the expression of [CDK2/CDK4] , and reduced the expression of p21 ( waf1/cip1 ) /p27 ( kip1 ) . Positive_regulation CDK5 CAPN8 17610816 1768592 We propose a mechanistic model by which mitochondrial toxin leads to *mediated* [Cdk5] activation , reduced Prx2 activity , and decreased capacity to eliminate ROS . Positive_regulation CDK5 CAPN8 19591849 2122816 We demonstrate , using pharmacological tools , that PKA activation causes increase of calcium levels , leading to [cyclin dependent kinase 5] *activation* by proteolysis of p35 to p25 and glycogen synthase kinase 3beta activation by its phosphorylation at tyrosine 216 . Positive_regulation CDK5 CCND1 10437914 634631 overexpression in mouse epidermis *increases* [cyclin dependent kinase] activity and cell proliferation in vivo but does not affect skin tumor development . Positive_regulation CDK5 CCND1 10995875 733637 Inhibition of expression or *induction* of [cyclin dependent kinase] inhibitor p21WAF1 expression was found in mimosine treated lung cancer cells . Positive_regulation CDK5 CCND1 22001116 2522203 In contrast , ectopic overexpression of Clmn produces an increase in the [cyclin dependent kinase] *inhibitor* , p21 ( Cip1 ) , a decrease in protein and an increase in hypophosphorylated Rb , showing that Clmn participates in G ( 1 ) /S arrest . Positive_regulation CDK5 EPHB2 17117479 1677407 In addition , we provide evidence that the signaling *regulates* [Cyclin dependent kinase 5 (Cdk5)] activity and stability of tumor suppressor p53 . Positive_regulation CDK5 EPHB2 20855497 2325851 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Positive_regulation CDK5 EPHB2 24498195 2913867 MAP kinase activation in spinal cord *regulates* phosphorylation of [Cdk5] at serine 159 and contributes to peripheral inflammation induced pain/hypersensitivity . Positive_regulation CDK5 FAS 17351056 1733960 Loss of *results* in reduced type A [cyclin dependent kinase] activity , inhibits mitotic progression , and promotes a precocious and systemic switch to the endocycle program . Positive_regulation CDK5 ID1 23342268 2712735 We propose that increased and Id3 expression *attenuates* all three [cyclin dependent kinase] inhibitors ( CDKN2B , -1A , and -1B ) resulting in a more aggressive PCa phenotype . Positive_regulation CDK5 IFI27 20189989 2243002 [Cdk5] nuclear localization is *dependent* in nerve cells : implications for cell cycle suppression and caspase-3 activation . Positive_regulation CDK5 NES 17036052 1634548 When the underlying link between nestin and Cdk5 was analyzed , we observed that serves as a scaffold for Cdk5 , with binding restricted to a specific region following the alpha-helical domain of nestin , and that the presence and organization of nestin *regulated* the sequestration and activity of [Cdk5] , as well as the ubiquitylation and turnover of its regulator , p35 . Positive_regulation CDK5 NES 21278733 2409629 Blockade of dependent signaling inhibited ACh induced [Cdk5] *activation* and the dispersion of AChR clusters in cultured myotubes . Positive_regulation CDK5 TNF 10657902 664279 *promotes* human papillomavirus ( HPV ) E6/E7 RNA expression and [cyclin dependent kinase] activity in HPV immortalized keratinocytes by a ras dependent pathway . Positive_regulation CDK5 TNF 19049962 2023752 *regulates* [cyclin dependent kinase 5] activity during pain signaling through transcriptional activation of p35 . Positive_regulation CDK5 TNF 19049962 2023771 These findings suggest that *mediated* regulation of [Cdk5] activity plays an important role in inflammation induced pain signaling . Positive_regulation CDK5RAP1 TNF 19811499 2209163 TNF-alpha or conditioned media ( CM ) of *stimulated* [C4-2B] cells upregulated BMP-2 and BMP dependent Smad transcripts and inhibited receptor activator of NF-kappaB ligand transcripts in RAW 264.7 preosteoclast cells , respectively , implying that this factor may contribute to suppression of osteoclastogenesis via direct and paracrine mechanisms . Positive_regulation CDK6 CCND1 10437914 634632 overexpression in mouse epidermis *increases* [cyclin dependent kinase] activity and cell proliferation in vivo but does not affect skin tumor development . Positive_regulation CDK6 CCND1 10995875 733638 Inhibition of expression or *induction* of [cyclin dependent kinase] inhibitor p21WAF1 expression was found in mimosine treated lung cancer cells . Positive_regulation CDK6 CCND1 22001116 2522205 In contrast , ectopic overexpression of Clmn produces an increase in the [cyclin dependent kinase] *inhibitor* , p21 ( Cip1 ) , a decrease in protein and an increase in hypophosphorylated Rb , showing that Clmn participates in G ( 1 ) /S arrest . Positive_regulation CDK6 EPHB2 20855497 2325852 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Positive_regulation CDK6 EPHB2 21292437 2414594 Silencing *increased* CyclinD1 , [cyclindependent kinase 6 (CDK6)] and Bcl-2 expression in both mRNA and protein levels compared with Control RNAi . Positive_regulation CDK6 FAS 17351056 1733961 Loss of *results* in reduced type A [cyclin dependent kinase] activity , inhibits mitotic progression , and promotes a precocious and systemic switch to the endocycle program . Positive_regulation CDK6 ID1 23342268 2712737 We propose that increased and Id3 expression *attenuates* all three [cyclin dependent kinase] inhibitors ( CDKN2B , -1A , and -1B ) resulting in a more aggressive PCa phenotype . Positive_regulation CDK6 IFI27 21312237 2398679 WIN 55,212-2 also upregulated phospho-ERK1/2 , *induced* and Cip1/WAF1/p21 expression , decreased cyclin D1 and cyclin E expression , decreased Cdk 2 , Cdk 4 , and [Cdk 6] expression levels , and decreased phospho-Rb and E2F-1 expression . Positive_regulation CDK6 IL1B 17454300 1730129 inhibited type II collagen expression , but *activated* [CDK6] . Positive_regulation CDK6 TNF 10657902 664280 *promotes* human papillomavirus ( HPV ) E6/E7 RNA expression and [cyclin dependent kinase] activity in HPV immortalized keratinocytes by a ras dependent pathway . Positive_regulation CDK7 CCND1 10437914 634633 overexpression in mouse epidermis *increases* [cyclin dependent kinase] activity and cell proliferation in vivo but does not affect skin tumor development . Positive_regulation CDK7 CCND1 10995875 733639 Inhibition of expression or *induction* of [cyclin dependent kinase] inhibitor p21WAF1 expression was found in mimosine treated lung cancer cells . Positive_regulation CDK7 CCND1 22001116 2522207 In contrast , ectopic overexpression of Clmn produces an increase in the [cyclin dependent kinase] *inhibitor* , p21 ( Cip1 ) , a decrease in protein and an increase in hypophosphorylated Rb , showing that Clmn participates in G ( 1 ) /S arrest . Positive_regulation CDK7 EPHB2 20855497 2325853 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Positive_regulation CDK7 FAS 17351056 1733962 Loss of *results* in reduced type A [cyclin dependent kinase] activity , inhibits mitotic progression , and promotes a precocious and systemic switch to the endocycle program . Positive_regulation CDK7 ID1 23342268 2712739 We propose that increased and Id3 expression *attenuates* all three [cyclin dependent kinase] inhibitors ( CDKN2B , -1A , and -1B ) resulting in a more aggressive PCa phenotype . Positive_regulation CDK7 IFI27 24511319 2914430 Western blotting showed that there were no apparent changes of protein levels of Cyclin E1 , while expression significantly declined and the levels of CDC7 and [CDK7] obviously *increased* . Positive_regulation CDK7 TNF 10657902 664281 *promotes* human papillomavirus ( HPV ) E6/E7 RNA expression and [cyclin dependent kinase] activity in HPV immortalized keratinocytes by a ras dependent pathway . Positive_regulation CDK7 TNF 16874302 1600733 Upon *stimulation* of the cells by , NF-kappaB and [TFIIH] are rapidly recruited to the promoter together with additional Mediator and RNAP II , but CDK8 is lost . Positive_regulation CDK8 ANGPT1 12890486 1117466 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation CDK8 ANGPT1 16638932 1589726 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation CDK8 CCND1 10437914 634634 overexpression in mouse epidermis *increases* [cyclin dependent kinase] activity and cell proliferation in vivo but does not affect skin tumor development . Positive_regulation CDK8 CCND1 10995875 733640 Inhibition of expression or *induction* of [cyclin dependent kinase] inhibitor p21WAF1 expression was found in mimosine treated lung cancer cells . Positive_regulation CDK8 CCND1 22001116 2522209 In contrast , ectopic overexpression of Clmn produces an increase in the [cyclin dependent kinase] *inhibitor* , p21 ( Cip1 ) , a decrease in protein and an increase in hypophosphorylated Rb , showing that Clmn participates in G ( 1 ) /S arrest . Positive_regulation CDK8 CD14 16574244 1582638 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation CDK8 CHI3L1 18802121 1965025 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation CDK8 EDN2 7693285 231256 *induced* contraction and [mediator] release in human bronchus . Positive_regulation CDK8 EDN2 9124581 424059 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation CDK8 EPHB2 20138154 2227070 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation CDK8 EPHB2 20855497 2325854 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Positive_regulation CDK8 EPHB2 23684917 2796488 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation CDK8 FAS 17351056 1733963 Loss of *results* in reduced type A [cyclin dependent kinase] activity , inhibits mitotic progression , and promotes a precocious and systemic switch to the endocycle program . Positive_regulation CDK8 ID1 11278321 798183 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation CDK8 ID1 23342268 2712741 We propose that increased and Id3 expression *attenuates* all three [cyclin dependent kinase] inhibitors ( CDKN2B , -1A , and -1B ) resulting in a more aggressive PCa phenotype . Positive_regulation CDK8 IL1B 7859071 287109 The results showed that *increased* NKA-li selectively in the median eminence ( ME ) and [arcuate nucleus (ARC)] of castrated rats only . Positive_regulation CDK8 IL1B 9810029 545620 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation CDK8 ITGB2 9152024 430913 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation CDK8 LBP 16574244 1582639 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation CDK8 TLR7 19631980 2131825 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation CDK8 TNF 10657902 664282 *promotes* human papillomavirus ( HPV ) E6/E7 RNA expression and [cyclin dependent kinase] activity in HPV immortalized keratinocytes by a ras dependent pathway . Positive_regulation CDK8 TNF 11159885 781422 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation CDK8 TNF 12524657 1047952 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation CDK8 TNF 14550746 1152728 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation CDK8 TNF 14982858 1214530 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation CDK8 TNF 17307735 1719089 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation CDK8 TNF 17988550 1821508 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation CDK8 TNF 18675993 2011432 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation CDK8 TNF 21904602 2478311 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation CDK8 TNF 23684917 2796487 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation CDK8 TNF 2788206 116806 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation CDK8 TNF 3292408 94749 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation CDK8 TNF 8453746 215222 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation CDK8 TNF 8679220 372475 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation CDK9 CCND1 10437914 634635 overexpression in mouse epidermis *increases* [cyclin dependent kinase] activity and cell proliferation in vivo but does not affect skin tumor development . Positive_regulation CDK9 CCND1 10995875 733641 Inhibition of expression or *induction* of [cyclin dependent kinase] inhibitor p21WAF1 expression was found in mimosine treated lung cancer cells . Positive_regulation CDK9 CCND1 21847632 2524266 We found that , in lung cancer cell lines and in nude mice , Interleukin-7/Interleukin-7 receptor increased the expression of and phosphorylation of c-Fos/c-Jun , *induce* c-Fos and c-Jun [heterodimer] formation , and enhanced c-Fos/c-Jun DNA binding activity to regulate cyclin D1 . Positive_regulation CDK9 CCND1 22001116 2522211 In contrast , ectopic overexpression of Clmn produces an increase in the [cyclin dependent kinase] *inhibitor* , p21 ( Cip1 ) , a decrease in protein and an increase in hypophosphorylated Rb , showing that Clmn participates in G ( 1 ) /S arrest . Positive_regulation CDK9 EPHB2 20855497 2325855 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( Waf1/Cip1 ) [cyclin dependent kinase] inhibitor , and induction of senescence . Positive_regulation CDK9 FAS 17351056 1733964 Loss of *results* in reduced type A [cyclin dependent kinase] activity , inhibits mitotic progression , and promotes a precocious and systemic switch to the endocycle program . Positive_regulation CDK9 ID1 23342268 2712743 We propose that increased and Id3 expression *attenuates* all three [cyclin dependent kinase] inhibitors ( CDKN2B , -1A , and -1B ) resulting in a more aggressive PCa phenotype . Positive_regulation CDK9 PLAU 10446176 636380 This new *induced* Stat2-Stat1 [heterodimer] binds to GAS ( the interferon-gamma activation site ) distinct from the interferon stimulated response element to which the p48 protein containing complexes generally bind . Positive_regulation CDK9 TNF 10657902 664283 *promotes* human papillomavirus ( HPV ) E6/E7 RNA expression and [cyclin dependent kinase] activity in HPV immortalized keratinocytes by a ras dependent pathway . Positive_regulation CDK9 TNF 15528190 1360047 did not *regulate* expression or localization of [CDK9] or its regulatory partner Cyclin T . Positive_regulation CDK9 TNF 15528190 1360049 However , *stimulated* [CDK9] binding to Cyclin T and MMP-9 gene occupancy by both CDK9 and the serine 2-phosphorylated form of RNA polymerase II . Positive_regulation CDK9 TNF 15677444 1395381 We identified importin alpha3 and importin alpha4 as the main importin alpha isoforms mediating *stimulated* NF-kappaB p50/p65 [heterodimer] translocation into the nucleus . Positive_regulation CDK9 TNF 16604092 1562646 In accordance with this result , rosmarinic acid also inhibited TNF-alpha induced phosphorylation and degradation of IkappaB-alpha , as well as nuclear translocation of NF-kappaB [heterodimer] *induced* by . Positive_regulation CDK9 TNF 17675290 1794079 By electrophoretic mobility shift assay analyses , and lipopolysaccharide *induce* strong p65/p50 and p65/c-Rel [heterodimer] binding to both NF-kappaB and TF-kappaB probes . Positive_regulation CDK9 TNF 21484152 2428308 Western blot analysis allowed assessing the inhibitory effect of the neem extract on *induced* degradation of inhibitor of ?B ( I?B ) and nuclear translocation of the NF-?B p50/p65 [heterodimer] . Positive_regulation CDK9 TNF 22334708 2580724 Knockdown analysis using 293FT reporter cells that endogenously express these five proteins at low levels clearly showed that DPF3a and DPF3b , which are produced from the DPF3 gene by alternative splicing , are the most critical for the RelA/p50 NF-?B [heterodimer] transactivation *induced* by stimulation . Positive_regulation CDK9 TNF 9528954 496215 The treatment with the antioxidants 20 mM N-acetyl-L-cysteine (NAC) and 10 microM pyrrolidine dithiocarbamate ( PDTC ) inhibited the *dependent* activation of p65-p50 [heterodimer] but not the p50-p50 homodimer , indicating that generation of oxidants is required for the activation of the heterodimer NF-kappaB . Positive_regulation CDK9 TP63 9614940 509534 In order to elucidate the *role* of in the [heterodimer] , chimeric HIV-1/FIV RT heterodimers were constructed and characterized . Positive_regulation CDKN1A AGR2 10761703 683341 The inhibitory effects of genistein on cell growth proliferation were associated with arrest in cell cycle progression concomitant with a marked inhibition of cyclin B1 and an *induction* of Cdk inhibitor [p21] ( WAF1/CIP1 ) in a p53 independent manner . Positive_regulation CDKN1A CCND1 10377442 623836 Silibinin induced G1 arrest was associated with a marked decrease in the kinase activity of cyclin dependent kinases (CDKs) and associated cyclins because of a highly significant decrease in , CDK4 , and CDK6 levels and an *induction* of [Cip1/p21] and Kip1/p27 followed by their increased binding with CDK2 . Positive_regulation CDKN1A CCND1 10474686 642364 Overexpression of the cyclin D1 gene seems to lead to growth arrest in a variety of human cancers , possibly through the *induction* of [p21] by . Positive_regulation CDKN1A CCND1 10952788 724111 Thus , FR901228 , while not directly inhibiting kinase activity , causes downregulation and a p53 independent [p21] *induction* , leading to inhibition of CDK and dephosphorylation of Rb resulting in growth arrest in the early G1 phase . Positive_regulation CDKN1A CCND1 10995875 733642 Inhibition of expression or *induction* of cyclin dependent kinase inhibitor [p21WAF1] expression was found in mimosine treated lung cancer cells . Positive_regulation CDKN1A CCND1 10995875 733651 Our results demonstrated that mimosine inhibits and *induces* [p21WAF1] expression in vivo . Positive_regulation CDKN1A CCND1 11114718 759176 The kinase activities of cyclin D/CDK4 , 6 and cyclin E/CDK2 complexes were only slightly elevated , consistent with the findings that coordinate increases in p21 , and cyclin E *resulted* in an increase in [cyclin/CDK/p21] complexes . Positive_regulation CDKN1A CCND1 11162569 782180 Lower activity of CCAAT/enhancer binding protein and expression of cyclin E , but not , *activating* protein-1 and [p21] ( WAF1 ) , after partial hepatectomy in obstructive jaundice . Positive_regulation CDKN1A CCND1 11170841 763223 This inhibition correlated significantly with reduced and *increased* [p21] protein expression . Positive_regulation CDKN1A CCND1 11305325 803790 Western analyses of transient and stable clones revealed that upregulation of [p21WAF1] in stable NIH 3T3/mot-2 cells may be *mediated* by and cdk-2 . Positive_regulation CDKN1A CCND1 12032842 948149 Inhibition of p42/p44-MAPK with the chemical inhibitor PD98059 , and activation of AKT/P70S6K and p38-MAPK with insulin , produced growth arrest ( precluding the expression of PCNA , and retinoblastoma at the hyperphosphorylated state and *inducing* the expression of the cell cycle inhibitor [p21] ( Cip ) ) and myogenesis ( multinucleated myotubes formation and induction of creatine kinase , caveolin-3 and alpha-actin ) . Positive_regulation CDKN1A CCND1 14566962 1155090 This was associated with increased protein content of and Cdk4 and decreased *activation* of [p21] ( cip1 ) and p27 ( kip1 ) . Positive_regulation CDKN1A CCND1 14670956 1210982 ERK activation was found to be required for critical downstream effects of PKC/PKC alpha activation , including down-regulation , [p21] ( Waf1/Cip1 ) *induction* , and cell cycle arrest . Positive_regulation CDKN1A CCND1 15499572 1374761 The levels of expression of G1/S-phase related proteins , such as , cyclin dependent kinase (cdk)4 , cdk6 , and proliferating cell nuclear antigen , were reduced and a cdk inhibitor , [p21(Cip1)] , was *induced* in rPCT1-CM treated TR-iBRB2 cells . Positive_regulation CDKN1A CCND1 15694666 1371712 Taken together , our results suggest that fibronectin stimulates lung cancer carcinoma cell growth by reducing the cyclin dependent kinase inhibitor [p21] and by *inducing* gene expression . Positive_regulation CDKN1A CCND1 17948060 1825833 These genetic results suggest that [p21] *acts* through the complex to support tumor growth , and establish the utility of using a somatic cell modeling system for defining the contribution proteins make to tumor development . Positive_regulation CDKN1A CCND1 18464245 1921421 This inhibitory phenomenon was associated with the reduced expressions of cyclin B1 , and cdc25B but *increased* expression of p27 ( Kip1 ) and [p21] ( Cip1 ) . Positive_regulation CDKN1A CCND1 19576743 2182743 The strongest anti-leukemic activity was shown by the methanol extract , which contained apigenin , baicalein , chrysin , luteolin and wogonin , with an IpC50 of 43 microg/ml ( corresponding to 1.3mg/ml of dried plant material ) which correlated with and Cdc25A suppression and [p21] *induction* . Positive_regulation CDKN1A CCND1 19724864 2133970 The strongest anti-proliferative activity was determined for the petroleum ether extract with an IpC50 of approximately 5.8 microg/ml medium ( referring to 1 mg dried plant ) which correlated with suppression and [p21] *induction* . Positive_regulation CDKN1A CCND1 20801098 2324493 inhibits p300 dependent RUNX3 acetylation and negatively *regulates* cyclin dependent kinase (cdk) inhibitor [p21] expression . Positive_regulation CDKN1A CCND1 21312237 2398680 WIN 55,212-2 also upregulated phospho-ERK1/2 , *induced* Kip1/p27 and [Cip1/WAF1/p21] expression , decreased and cyclin E expression , decreased Cdk 2 , Cdk 4 , and Cdk 6 expression levels , and decreased phospho-Rb and E2F-1 expression . Positive_regulation CDKN1A CCND1 21575346 2430309 At the saccular stage , the expression of decreased significantly and the [p21CIP1] expression *increased* significantly . Positive_regulation CDKN1A CCND1 21782877 2490178 The cell cycle arrest in the G0/G1 by 25-MHA was well correlated with the downregulation of , cyclin dependent kinase ( CDK4 ) , CDK2 , cyclin A , phosphorylated retinoblastoma protein ( pRb ) , and *induction* of cdk inhibitor p21 ( [WAF1/Cip1] ) protein . Positive_regulation CDKN1A CCND1 22001116 2522213 In contrast , ectopic overexpression of Clmn produces an increase in the cyclin dependent kinase *inhibitor* , [p21] ( Cip1 ) , a decrease in protein and an increase in hypophosphorylated Rb , showing that Clmn participates in G ( 1 ) /S arrest . Positive_regulation CDKN1A CCND1 22052467 2629353 Furthermore , both ß-catenin levels and activity fell to half the original levels with a concomitant reduction of cell proliferation inducing , c-Myc , and *induction* of cytostatic protein [p21] before caspase-3 activation . Positive_regulation CDKN1A CCND1 22362714 2520913 The antiproliferative effects of FHL3 on breast cancer cell growth were associated with both the G1 and the G2/M cell cycle arrest , which was accompanied by a marked inhibition of the G1-phase marker and the G2/M-phase marker cyclin B1 as well as the *induction* of the cyclin dependent kinase inhibitor [p21] ( WAF1/CIP1 ) , a negative regulator of cell cycle progression at G1 and G2 . Positive_regulation CDKN1A CCND1 22460505 2637149 Cell cycle analysis indicated thioridazine induced the down-regulation of , cyclin A and CDK4 , and the *induction* of [p21] and p27 , a cyclin dependent kinase inhibitor . Positive_regulation CDKN1A CCND1 22814742 2692067 degradation and [p21] *induction* contribute to growth inhibition of colorectal cancer cells induced by epigallocatechin-3-gallate . Positive_regulation CDKN1A CCND1 7671232 322622 p53 , through [p21] ( WAF1/CIP1 ) , *induces* synthesis . Positive_regulation CDKN1A CCND1 8657154 364911 These results provide evidence that [p21WAF-1] *acts* through and cyclin E-cdk2 complexes in vivo to induce the growth suppression . Positive_regulation CDKN1A CCND1 9191053 437637 Regulated ectopic expression of *induces* transcriptional activation of the cdk inhibitor [p21] gene without altering cell cycle progression . Positive_regulation CDKN1A CCND1 9191053 437638 In a first step toward elaborating the mechanism for *induction* of [p21] gene expression we show that co-expression of E2F-1 and DP-1 can specifically transactivate the p21 promoter . Positive_regulation CDKN1A CCND1 9191053 437640 In summary , our results demonstrate that ectopic expression of can *induce* gene expression of the cdk inhibitor [p21] through an E2F mechanism the consequences of which are not to growth arrest cells but possibly to stabilize cyclin D1/cdk function . Positive_regulation CDKN1A CCND1 9236224 445604 We have shown previously ( ) that NGF *induces* the expression of the p21 WAF1/CIP1/Sdi1 ( [p21] ) cyclin dependent kinase (Cdk) inhibitor protein and the G1 phase cyclin , . Positive_regulation CDKN1A EPHB2 10419906 632125 Furthermore , fMLP induced [p21rac] activation was not *inhibited* by broad tyrosine kinase inhibitors or specific inhibitors of , p38 mitogen activated protein kinase , Src , or phosphatidylinositol 3-kinases . Positive_regulation CDKN1A EPHB2 10602507 574941 Using pharmacological and transient transfection approaches , we showed that activation was necessary and *sufficient* for [p21] induction in MCF-7fms . Positive_regulation CDKN1A EPHB2 10753954 682479 Addition of a selective inhibitor of phosphorylation ( PD98059 ) *prevented* the subsequent phosphorylation of p70 ( S6k ) and the increase in [p21] protein . Positive_regulation CDKN1A EPHB2 10781803 687944 This implies that a link exists between activation and [p21] ( WAF ) and p27 ( kip1 ) *induction* in the process of terminal differentiation . Positive_regulation CDKN1A EPHB2 11088001 764975 Finally , the synergism between somatostatin and bFGF in the activation of *results* in an increased expression of the cyclin dependent kinase inhibitor [p21cip/WAF1] as molecular effector of the antiproliferative activity of somatostatin . Positive_regulation CDKN1A EPHB2 11688977 876053 Taken together , our data suggest that VES induces activation of PKC and PKC dependent hypophosphorylation of retinoblastoma protein , which results in induction of apoptosis , and that VES induced early activation of ERK and dependent *induction* of [p21] ( WAF1 ) are not required for apoptosis . Positive_regulation CDKN1A EPHB2 11821415 922604 Inhibition of activation by PD98059 or U0126 *attenuated* [p21] ( CIP1 ) induction , resulting in partial release of the G(2)/M cell cycle arrest induced by ETOP . Positive_regulation CDKN1A EPHB2 11911463 924205 Expression of [p21WAF1] is *dependent* on the activation of during vitamin E-succinate induced monocytic differentiation . Positive_regulation CDKN1A EPHB2 11911463 924206 Inhibition of the activity by PD98059 also *diminished* the VES induced [p21WAF1] protein expression , but did not change the phosphorylation state of the retinoblastoma protein . Positive_regulation CDKN1A EPHB2 12370305 995748 We demonstrated that in PMA induced adherent cells , upregulation of [p21] ( Cip1/Waf1 ) *requires* the activation and nuclear translocation of phosphorylated extracellular signal regulated kinase ( ) . Positive_regulation CDKN1A EPHB2 12370305 995754 Finally , we demonstrated that inhibition of ROCK restores nuclear distribution of and *activation* of [p21] ( Cip1/Waf1 ) expression . Positive_regulation CDKN1A EPHB2 12370305 995756 Based on these findings , we propose that a ROCK mediated signal is involved in interfering with the process of *mediated* [p21] ( Cip1/Waf1 ) induction in PMA induced proapoptotic TF-1 and D2 cells . Positive_regulation CDKN1A EPHB2 12381673 997376 Extracellular zinc stimulates *dependent* activation of [p21] ( Cip/WAF1 ) and inhibits proliferation of colorectal cancer cells . Positive_regulation CDKN1A EPHB2 12726921 1086344 PD98059 , an inhibitor of , and SB202190 , an inhibitor of p38 , *inhibited* vanadate induced cell growth arrest , upregulation of [p21] and cdc2 , and degradation of cdc25C . Positive_regulation CDKN1A EPHB2 12816758 1157189 Moreover , this activation and cyclin D1 and [p21] ( Cip/WAF1 ) *induction* were abolished by PD-98059 pretreatment . Positive_regulation CDKN1A EPHB2 12816758 1157196 The differential regulations of cell growth , activities , and cyclin D1 and [p21] ( Cip/WAF1 ) *inductions* were also observed in serum enriched medium containing higher zinc concentrations . Positive_regulation CDKN1A EPHB2 14516791 1147194 Moreover , ANXA1 reduces proliferation by mediated disruption of the actin cytoskeleton and ablation of cyclin D1 protein expression and not by ERK mediated *induction* of the cyclin dependent kinase , CDK2 , inhibitor [p21] ( cip/waf ) . Positive_regulation CDKN1A EPHB2 14647439 1188302 The levels of HO-1 and [p21] induced were significantly *inhibited* by p38 mitogen activated protein kinase ( p38 MAPK ) inhibitor ( SB203580 ) and inhibitor ( PD098059 ) . Positive_regulation CDKN1A EPHB2 14679005 1179054 Enforced expression of doxycycline-inducible p21 ( CIP1 ) or constitutively active MEK1 significantly diminished 17-AAG/SAHA mediated lethality , indicating that interference with activation and [p21] ( CIP1 ) *induction* play important functional roles in the lethal effects of this regimen . Positive_regulation CDKN1A EPHB2 15122344 1258558 Moreover , [p21] induction was dramatically *attenuated* by inhibitors PD98059 and U0126 . Positive_regulation CDKN1A EPHB2 15665589 1350435 However , not all the cells appeared to respond to pathway dependent [p21Cip/WAF1] *induction* . Positive_regulation CDKN1A EPHB2 15979845 1497977 Using pharmacological inhibitors specific for MAP kinase family members , we found that , but not JNK or p38 , is *required* for TGF-beta1 induction of [p21WAF1/Cip1] . Positive_regulation CDKN1A EPHB2 16159599 1455966 JTT-705 induced the upregulation of [p-p21] ( waf1 ) , and this effect was *blocked* by dominant negative Ras ( N17 ) , but not by inhibitors of p38 MAPK or . Positive_regulation CDKN1A EPHB2 16248979 1477048 In addition , the transcription factor Sp1 that is involved in the *mediated* control of [p21WAF1] regulation in VSMC in response to PDGF has now been identified . Positive_regulation CDKN1A EPHB2 16806947 1599839 The antiproliferative effect was correlated with activation and [p21] ( waf1 ) *induction* . Positive_regulation CDKN1A EPHB2 17941827 1849408 Heregulin beta1 promotes breast cancer cell proliferation through dependent *induction* of cyclin D1 and [p21Cip1] . Positive_regulation CDKN1A EPHB2 18181040 1856517 and inhibitors of ( PD98059 ) and PKC ( GF109203X ) *prevented* [p21] induction and abolished the PMA survival effect . Positive_regulation CDKN1A EPHB2 18394670 1920032 The differentiated cells arrested in G ( 0 ) /G ( 1 ) phase of cell cycle and showed early activation of ERK1/2 pathway ( 3 h ) along with *dependent* [p21] ( Cip/WAF1 ) ( p21 ) up-regulation and expression of p27 ( Kip1 ) and Bcl-2 . Positive_regulation CDKN1A EPHB2 18949380 1978836 Overall , the TsA activated ERK pathway plays an important role in cell cycle arrest and apoptosis through the *dependent* induction of [p21] in Ras related human cancer cells . Positive_regulation CDKN1A EPHB2 20838657 2319084 Here , we show that TPO induces cell-cycle arrest in the megakaryocytic UT7-MPL cell line by the activation of the pathway , *induction* of [p21CIP] transcription , and senescence markers through EGR1 activation . Positive_regulation CDKN1A EPHB2 20855497 2325856 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the [p21] ( Waf1/Cip1 ) cyclin dependent kinase inhibitor , and induction of senescence . Positive_regulation CDKN1A EPHB2 21642427 2454975 Although ELK-1 was activated by ERK , JNK , and p38 MAPK in response to NaASO ( 2 ) , ELK-1 mediated activation of the [p21] promoter was largely *dependent* on . Positive_regulation CDKN1A EPHB2 23434831 2744447 Moreover , asperolide A significantly activated MAP kinases ( ERK1/2 , JNK and p38 MAP kinase ) by phosphorylation , and only the inhibition of activation by PD98059 reversed downregulation of G2/M regulatory proteins CDC2 , and *suppressed* upregulation of [p21] and p-p53 levels . Positive_regulation CDKN1A EPHB2 23772367 2714475 VN attenuated radiation induced expression of p21 , an inhibitor of cell cycle progression , and selectively inhibited and p38 MAPK dependent [p21] *induction* after radiation exposure through regulation of the activity of GSK-3ß . Positive_regulation CDKN1A EPHB2 23959801 2845483 Remarkably , activity was *necessary* for mortalin depletion to induce [p21] ( CIP1 ) expression in B-Raf ( V600E ) -transformed cancer cells regardless of their p53 status . Positive_regulation CDKN1A FAS 10754295 682534 signaling in T lymphocytes *induces* the cell cycle control protein [p21cip-1/WAF-1] , which promotes apoptosis . Positive_regulation CDKN1A FAS 10754295 682536 However , *induced* up-regulation of [p21cip-1/WAF-1] in T cells was p53 independent . Positive_regulation CDKN1A FAS 10754295 682537 We conclude that in T cells , ligation of and activation of caspases *cause* the induction of [p21cip-1/WAF-1] , which acts to promote cell death . Positive_regulation CDKN1A FAS 14767544 1207631 In SK-Br3 cells , cerulenin induced inhibition of activity *resulted* in down-regulation of p53 , and up-regulation of cyclin dependent kinase inhibitor (CDKi) [p21WAF1/CIP1] . Positive_regulation CDKN1A FAS 19268879 2055622 *increased* the level of TGF-beta1 , Smad-3 , and [p21] protein in ovarian cancer cells known to be more sensitive to their inhibitory effect . Positive_regulation CDKN1A FHL1 19139564 2032181 Casein kinase 1delta , but not the TGF-beta receptor , was required for the FHL mediated TGF-beta-like responses , including increased phosphorylation of Smad2/3 , interaction of Smad2/3 and Smad4 , nuclear accumulation of Smad proteins , *activation* of the tumor suppressor gene [p21] , and repression of the oncogene c-myc. inhibited anchorage dependent and -independent growth of a human hepatoma cell line in vitro and tumor formation in nude mice . Positive_regulation CDKN1A FOXO1 11073996 748901 Furthermore , both PTEN and constitutively active *induce* p27 ( KIP1 ) protein but not [p21] . Positive_regulation CDKN1A ID1 12016143 942187 We found that expression *induced* phosphorylation of RB and down-regulation of p16(INK4a) but not [p21] ( Waf1 ) or p27 ( Kip1 ) . Positive_regulation CDKN1A IFI27 10530763 654513 Moreover , mimosine *induced* [p21CIP1] expression in H226 and H358 cells , while it activated expression in H322 cells . Positive_regulation CDKN1A IFI27 11759294 887708 Quercetin treatment , however , resulted in a moderate *increase* in [Cip1/p21] with no change in and a decrease in CDK4 and cyclin D1 . Positive_regulation CDKN1A IFI27 11909640 923740 Staurosporine *induced* upregulation of [p21] ( WAF-1 ) whereas ( Kip1 ) remained unaltered . Positive_regulation CDKN1A IFI27 12392819 1007786 Simultaneously , [p21] expression was markedly induced in *presence* of high levels of and p53 . Positive_regulation CDKN1A IFI27 17018599 1630149 The expression of cyclin dependent kinase inhibitors was profoundly affected with early activation and then repression of [p21(cip1/waf1)] and persistent *activation* of both ( kip1 ) and p57(kip2) , whereas genes involved in cell survival and proliferation were suppressed . Positive_regulation CDKN1A IL1B 15187102 1256323 *induces* [p21] ( Cip1/Waf1 ) , which may contribute to its inhibition of IGF-I activated Cdk2 . Positive_regulation CDKN1A ITGB2 16894473 1597165 ( 1A ) *stimulated* the promoter activity of [p21] ( cip1 ) and enhanced its transcription in SMMC-7721 cells . Positive_regulation CDKN1A JAG1 17325209 1706474 Both transcriptional induction of the Notch ligand by TGF-beta and endogenous levels of the Notch effector CSL *contribute* to [p21] induction and epithelial cytostasis . Positive_regulation CDKN1A JAG1 18757425 1956577 Conversely , forced expression of , activated NOTCH3 , or HEY1 *induced* p53 and [p21] ( WAF1/CIP1 ) . Positive_regulation CDKN1A KLF9 10749849 698420 The gut enriched ( Kruppel-like factor 4 ) *mediates* the transactivating effect of p53 on the [p21WAF1/Cip1] promoter . Positive_regulation CDKN1A MAP2K6 10854130 704225 We conclude that there is a strong reciprocal interaction between the SAP pathway involving JNK and the raf-MEK-MAP kinase pathway and that oncogenic [ras-p21] can be preferentially *inhibited* by inhibitors . Positive_regulation CDKN1A MAP2K6 16283431 1509509 The As2O3 induced [p21] activation was *attenuated* by inhibitors of EGFR and in a dose dependent manner . Positive_regulation CDKN1A MAP2K6 23959801 2845489 Remarkably , activity was *necessary* for mortalin depletion to induce [p21] ( CIP1 ) expression in B-Raf ( V600E ) -transformed cancer cells regardless of their p53 status . Positive_regulation CDKN1A RARB 12516107 1039277 Ectopic [p21sdi1] gene transfer *induces* expression and sensitizes human cancer cells to retinoid treatment . Positive_regulation CDKN1A RARB 15026551 1222788 Acyclic retinoid activates and *induces* transcriptional activation of [p21] ( CIP1 ) in HepG2 human hepatoma cells . Positive_regulation CDKN1A TNF 10644980 661658 *Induction* of [p21Waf1/Cip1] by requires NF-kappaB activity and antagonizes apoptosis in Ewing tumor cells . Positive_regulation CDKN1A TNF 11097743 755792 *induced* expression of [p21] ( WAF1 ) at protein and mRNA levels in a dose dependent fashion with an association with G ( 1 ) -arrest in human colon cancer cells WiDr that carry mutated p53 at codon 273 ( His ( 273 ) ) . Positive_regulation CDKN1A TNF 11097743 755794 Co-transfection of the p53 His ( 273 ) expression construct with a luciferase gene controlled by the p21 ( WAF1 ) promoter showed that the p53 His ( 273 ) was inactive , although *increased* the transcriptional rate of [p21] ( WAF1 ) in these cells . Positive_regulation CDKN1A TNF 11097743 755796 These findings suggest that *induces* expression of [p21] ( WAF1 ) through a distinct pathway from Bax and that protein stabilization is an important mechanism in the expression of p21 ( WAF1 ) independent of p53 . Positive_regulation CDKN1A TNF 12761882 1091734 In these conditions the *induced* increase of [p21] ( waf1 ) is not sufficient to inhibit the high amount of cyclin D-bound complexes . Positive_regulation CDKN1A TNF 12795334 1098416 We found that can *increase* the cellular levels of p53 , [p21] and induce apoptosis in ME180S cells . Positive_regulation CDKN1A TNF 15326480 1296854 The present study described that , in the leukemic KG1 cells , *induced* no apoptosis but a senescence state characterized by prolonged growth arrest , increased beta-galactosidase activity , [p21WAF-1] induction , decreased telomerase activity , telomeric disturbances ( shortening , losses , fusions ) , and additional chromosomal aberrations . Positive_regulation CDKN1A TNF 15823554 1393906 *induces* differentiation of human peripheral blood mononuclear cells into osteoclasts through the induction of [p21] ( WAF1/Cip1 ) . Positive_regulation CDKN1A TNF 16216243 1476495 *induced* increases in [p21] expression resulting in partial cell cycle attenuation in the G1 phase . Positive_regulation CDKN1A TNF 16243830 1471167 Further investigation showed that silencing of hPEBP4 in MCF-7 cells promoted *induced* stability of p53 , up-regulation of phospho-p53ser15 , [p21waf/cip] , and Bax , and down-regulation of Bcl-2 and Bcl-xL , which were shown to depend on extracellular signal regulated kinase 1/2 and c-jun NH2-terminal kinase activation by hPEBP4 silencing . Positive_regulation CDKN1A TNF 17565690 1763080 induced inhibition of proliferation and *enhanced* the expression of [p21cip/waf1] and p27kip1 in LN-18 cells . Positive_regulation CDKN1A TNF 17565690 1763086 Spheroidogenesis enhanced p27 expression and [p21] *induced* by was significantly increased in the MCS compared to monolayers . Positive_regulation CDKN1A TNF 17565690 1763087 Our findings provide evidence that *induced* [p21] might be regulated by NF-kappaB or p53 independently . Positive_regulation CDKN1A TNF 20307318 2244589 Over-expression of secretory clusterin also blocks the *mediated* induction of [p21] and abrogates the cleavage of Bax to t-Bax , rendering the MCF-7CLU cells significantly more resistant to the cytokine than the parental cells . Positive_regulation CDKN1A TNF 7629160 316645 also *increased* the expression level of Cip1 ( [p21] ) protein in a dose dependent manner . Positive_regulation CDKN1A TNF 8990624 404205 Actinomycin D markedly inhibited *induced* [p21] mRNA expression , suggesting that the p21 gene is induced at the transcriptional level . Positive_regulation CDKN1A TNF 9478957 487039 was unable to *induce* [p21WAF1] in either cell line but affected the stability of this protein in apoptotically responsive ME-180S cells . Positive_regulation CDKN1A TNF 9478957 487040 In addition , *induced* [p21WAF1] proteolysis may be mediated by an apoptotic protease and may contribute to the apoptotic process by disrupting p53 signaling , altering cell cycle inhibition , and limiting cellular recovery from genotoxic stress . Positive_regulation CDKN1A TNF 9588176 504632 Prevention of mediated *induction* of [p21WAF1/CIP1] sensitizes MCF-7 carcinoma cells to TNF induced apoptosis . Positive_regulation CDKN1A TNF 9588176 504633 [p21] *induction* by > 0.5 ng/ml in MRC-5 and MCF-7 cells correlated with the inhibition of cell growth . Positive_regulation CDKN1A TNF 9588176 504634 Thus , *induced* [p21] accompanied by growth arrest may counteract or delay TNF cytotoxicity in MCF-7 cells . Positive_regulation CDKN1A TNFSF10 11992615 938782 In addition , combined and wortmannin treatment *resulted* in cleavage of several proteins : PARP , Akt , [p21/WAF1] , and MDM2 as well as dephosphorylation of Akt . Positive_regulation CDKN1A TNFSF10 18483205 1939093 However , the *induction* of the negative cell cycle regulator [p21WAF1] by FasL or in either CD4+ or CD8+ T-cell blasts seems to be the main regulatory mechanism . Positive_regulation CDKN1A TP63 10761704 683343 Ad-p73beta and *induced* endogenous [p21] gene expression more effectively than Ad-p73alpha and Ad-p51B , respectively . Positive_regulation CDKN1A TP63 12374749 996668 Over expression of wild-type , but not deletion mutant , SSRP1 remarkably enhanced *dependent* luciferase activity , G1 arrest , apoptosis and expression of endogenous PIG3 , [p21] ( Waf1/cip1 ) and MDM2 in human p53-deficient lung carcinoma H1299 cells and mouse embryonic fibroblasts . Positive_regulation CDKN1A TP63 15965232 1446098 p300 , but not its acetylase-defective mutant AT2 , stimulated *dependent* transcription and induction of [p21] in cells , consequently leading to G1 arrest . Positive_regulation CDKN1A TP63 15965232 1446100 These results suggest that p300 regulates *dependent* transcription of [p21] . Positive_regulation CDKN1A TP63 21480565 2361627 As p21 , a transcriptional target of the p53 family , is necessary for maintaining G2/M arrest , we analyzed the *roles* of p53 and in modulating IGF1 stimulated [p21] expression . Positive_regulation CDKN1B CCND1 16924241 1692233 Mutant B-RAF signaling and *regulate* Cks1/S-phase kinase associated protein 2-mediated degradation of [p27Kip1] in human melanoma cells . Positive_regulation CDKN1B CCND1 8780883 380291 Increased expression of in a murine mammary epithelial cell line *induces* [p27kip1] , inhibits growth , and enhances apoptosis . Positive_regulation CDKN1B EPHB2 15930121 1433867 phosphorylates p66shcA on Ser36 and subsequently *regulates* [p27kip1] expression via the Akt-FOXO3a pathway : implication of p27kip1 in cell response to oxidative stress . Positive_regulation CDKN1B FAS 11848481 893459 As malignant gliomas express Fas at high levels , the relationship between *mediated* apoptosis and [p27Kip1] expression may improve therapeutic approaches for treating gliomas . Positive_regulation CDKN1B FOXO1 11994454 939025 The forkhead transcription factor *regulates* transcription of [p27Kip1] and Bim in response to IL-2 . Positive_regulation CDKN1B FOXO1 12891709 1117760 To understand mechanisms by which IGF-I signals the downregulation of p27Kip1 in rat skeletal satellite cells , the *role* of Forkhead transcription factor in transcriptional activity of [p27Kip1] was examined . Positive_regulation CDKN1B TNF 17565690 1763081 induced inhibition of proliferation and *enhanced* the expression of p21cip/waf1 and [p27kip1] in LN-18 cells . Positive_regulation CDKN1C COPS2 23187808 2707765 CDK inhibitor [p57 (Kip2)] is negatively *regulated* by 6 . Positive_regulation CDKN1C COPS3 23187808 2707762 CDK inhibitor [p57 (Kip2)] is negatively *regulated* by 6 . Positive_regulation CDKN1C COPS4 23187808 2707760 CDK inhibitor [p57 (Kip2)] is negatively *regulated* by 6 . Positive_regulation CDKN1C COPS5 23187808 2707763 CDK inhibitor [p57 (Kip2)] is negatively *regulated* by 6 . Positive_regulation CDKN1C COPS6 23187808 2707761 CDK inhibitor [p57 (Kip2)] is negatively *regulated* by 6 . Positive_regulation CDKN1C COPS6 23187808 2707773 These data suggest that is an important negative regulator of p57 (Kip2) , and that overexpression of CSN6 in many types of cancer could *lead* to decreased expression of [p57 (Kip2)] and result in promoted cancer cell growth . Positive_regulation CDKN1C COPS8 23187808 2707764 CDK inhibitor [p57 (Kip2)] is negatively *regulated* by 6 . Positive_regulation CDKN1C CUL1 12925736 1135312 Finally , the purified recombinant *mediated* [p57Kip2] ubiquitylation in vitro in a manner dependent on the presence of the cyclin E-CDK2 complex . Positive_regulation CDKN1C CXCL12 22541097 2590341 Moreover , *increased* [p57kip2] expression in normal BMMNC in dose dependent manner , but BMMNC from MDS patients showed no response to SDF-1 . Positive_regulation CDKN1C CXCL12 22541097 2590342 Furthermore , *induced* [p57kip2] expression in BMMNC , and the decreasing response of BMMNC to SDF-1 may contribute to the low expression of p57kip2 in MDS patients . Positive_regulation CDKN1C CXCL12 22889515 2642367 We also searched the *role* of signal in [p57kip2] expression in vitro . Positive_regulation CDKN1C CXCL12 22889515 2642369 p57kip2 expression in bone marrow mononuclear cells of normal controls increased significantly when co-cultured with SDF-1 in vitro , which could be blocked by AMD3100 , whereas only *induced* a mild increase in [p57kip2] in MDS . Positive_regulation CDKN1C CXCL12 22889515 2642370 Reduced response to *contributed* to low expression of [p57kip2] in MDS cases . Positive_regulation CDKN1C E2F1 20106982 2226563 Surprisingly , we find that CDKN1C mediated repression of RNA pol II phosphorylation is E2F1 dependent , suggesting that may *direct* [CDKN1C] to chromatin . Positive_regulation CDKN1C FLI1 18271016 1911578 In this report , we show that depletion of in Ewing 's cell lines *results* in a senescence phenotype , a marked increase in expression of the G1/S regulatory proteins p27 ( kip1 ) and [p57(kip2)] , and a significant decrease in cyclin D1 and CDK2 . Positive_regulation CDKN1C HDAC1 19221586 2039687 The , Romidepsin , specifically *restored* [CDKN1C] expression in rhabdoid tumor cells through promoter histone H3 and H4 acetylation , recapitulating the effect of SMARCB1 on CDKNIC allelic expression , and induced cell cycle arrest in G401 and STM91-01 rhabdoid tumor cell lines . Positive_regulation CDKN1C HDAC10 19221586 2039685 The , Romidepsin , specifically *restored* [CDKN1C] expression in rhabdoid tumor cells through promoter histone H3 and H4 acetylation , recapitulating the effect of SMARCB1 on CDKNIC allelic expression , and induced cell cycle arrest in G401 and STM91-01 rhabdoid tumor cell lines . Positive_regulation CDKN1C HDAC11 19221586 2039686 The , Romidepsin , specifically *restored* [CDKN1C] expression in rhabdoid tumor cells through promoter histone H3 and H4 acetylation , recapitulating the effect of SMARCB1 on CDKNIC allelic expression , and induced cell cycle arrest in G401 and STM91-01 rhabdoid tumor cell lines . Positive_regulation CDKN1C HDAC2 19221586 2039688 The , Romidepsin , specifically *restored* [CDKN1C] expression in rhabdoid tumor cells through promoter histone H3 and H4 acetylation , recapitulating the effect of SMARCB1 on CDKNIC allelic expression , and induced cell cycle arrest in G401 and STM91-01 rhabdoid tumor cell lines . Positive_regulation CDKN1C HDAC3 19221586 2039689 The , Romidepsin , specifically *restored* [CDKN1C] expression in rhabdoid tumor cells through promoter histone H3 and H4 acetylation , recapitulating the effect of SMARCB1 on CDKNIC allelic expression , and induced cell cycle arrest in G401 and STM91-01 rhabdoid tumor cell lines . Positive_regulation CDKN1C HDAC4 19221586 2039680 The , Romidepsin , specifically *restored* [CDKN1C] expression in rhabdoid tumor cells through promoter histone H3 and H4 acetylation , recapitulating the effect of SMARCB1 on CDKNIC allelic expression , and induced cell cycle arrest in G401 and STM91-01 rhabdoid tumor cell lines . Positive_regulation CDKN1C HDAC5 19221586 2039684 The , Romidepsin , specifically *restored* [CDKN1C] expression in rhabdoid tumor cells through promoter histone H3 and H4 acetylation , recapitulating the effect of SMARCB1 on CDKNIC allelic expression , and induced cell cycle arrest in G401 and STM91-01 rhabdoid tumor cell lines . Positive_regulation CDKN1C HDAC6 19221586 2039681 The , Romidepsin , specifically *restored* [CDKN1C] expression in rhabdoid tumor cells through promoter histone H3 and H4 acetylation , recapitulating the effect of SMARCB1 on CDKNIC allelic expression , and induced cell cycle arrest in G401 and STM91-01 rhabdoid tumor cell lines . Positive_regulation CDKN1C HDAC7 19221586 2039683 The , Romidepsin , specifically *restored* [CDKN1C] expression in rhabdoid tumor cells through promoter histone H3 and H4 acetylation , recapitulating the effect of SMARCB1 on CDKNIC allelic expression , and induced cell cycle arrest in G401 and STM91-01 rhabdoid tumor cell lines . Positive_regulation CDKN1C HDAC8 19221586 2039679 The , Romidepsin , specifically *restored* [CDKN1C] expression in rhabdoid tumor cells through promoter histone H3 and H4 acetylation , recapitulating the effect of SMARCB1 on CDKNIC allelic expression , and induced cell cycle arrest in G401 and STM91-01 rhabdoid tumor cell lines . Positive_regulation CDKN1C HDAC9 19221586 2039682 The , Romidepsin , specifically *restored* [CDKN1C] expression in rhabdoid tumor cells through promoter histone H3 and H4 acetylation , recapitulating the effect of SMARCB1 on CDKNIC allelic expression , and induced cell cycle arrest in G401 and STM91-01 rhabdoid tumor cell lines . Positive_regulation CDKN1C IGF2 9177379 434157 The stimulatory effect of ACTH on the 2.5-kb [p57KIP2] and H19 transcript accumulation was *enhanced* by exogenous and IGF-I . Positive_regulation CDKN1C KCNQ1 24371999 2882072 We found that disruption of *results* in reduced expression of Kcnqlot1 as well as increased expression of [Cdkn1c] , an imprinted gene that encodes a cell cycle inhibitor only when the mutation is on the paternal allele . Positive_regulation CDKN1C KCNQ1OT1 23243085 2731792 DNA methylation and gene expression analyses showed that the deletion led to an imprinting alteration restricted to the centromeric domain and resulting in silencing of and *activation* of [CDKN1C] and PHLDA2 . Positive_regulation CDKN1C KLF4 22017667 2562547 *up-regulated* the expression of GADD45ß , [p57(kip2)] and p27 ( kip1 ) . Positive_regulation CDKN1C MYLIP 20461750 2257625 and miR-222 negatively *regulate* expression of CDKN1B ( p27 ) and [CDKN1C] ( p57 ) , two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas . Positive_regulation CDKN1C NOTCH1 16033893 1436228 Here , we report that , in zebrafish , expression of the Cdki gene [cyclin dependent kinase inhibitor 1c] ( cdkn1c ) , a p57 homolog , is negatively *regulated* by signaling and that Cdkn1c function is required for neural plate cells to stop dividing and differentiate as neurons on schedule , even in the absence of Notch signaling activity . Positive_regulation CDKN1C NOTCH1 22705236 2633863 In this study , we show that the down-regulation of and Notch3 in two HCC cell lines *resulted* in Hes1 down-regulation , [CDKN1C/P57] up-regulation , and reduced cell growth . Positive_regulation CDKN1C NOTCH2 16033893 1436229 Here , we report that , in zebrafish , expression of the Cdki gene [cyclin dependent kinase inhibitor 1c] ( cdkn1c ) , a p57 homolog , is negatively *regulated* by signaling and that Cdkn1c function is required for neural plate cells to stop dividing and differentiate as neurons on schedule , even in the absence of Notch signaling activity . Positive_regulation CDKN1C NOTCH3 16033893 1436230 Here , we report that , in zebrafish , expression of the Cdki gene [cyclin dependent kinase inhibitor 1c] ( cdkn1c ) , a p57 homolog , is negatively *regulated* by signaling and that Cdkn1c function is required for neural plate cells to stop dividing and differentiate as neurons on schedule , even in the absence of Notch signaling activity . Positive_regulation CDKN1C NOTCH3 22705236 2633864 In this study , we show that the down-regulation of Notch1 and in two HCC cell lines *resulted* in Hes1 down-regulation , [CDKN1C/P57] up-regulation , and reduced cell growth . Positive_regulation CDKN1C NOTCH4 16033893 1436231 Here , we report that , in zebrafish , expression of the Cdki gene [cyclin dependent kinase inhibitor 1c] ( cdkn1c ) , a p57 homolog , is negatively *regulated* by signaling and that Cdkn1c function is required for neural plate cells to stop dividing and differentiate as neurons on schedule , even in the absence of Notch signaling activity . Positive_regulation CDKN1C PAK4 23873832 2839271 *regulates* the [cyclin dependent kinase inhibitor p57] ( kip2 ) in human breast cancer . Positive_regulation CDKN1C RTN4 21247704 2431081 The supplemented diets and also infection *led* to reduced [body weights (BWs)] of birds and impaired the feed conversion rate ( P < 0.001 ) . Positive_regulation CDKN1C SHH 15891769 1411553 Here , we show that signalling has the opposite effect in the zebrafish retina , where it leads to cell-cycle exit , and that this is *mediated* by transcriptional activation of the cyclin kinase inhibitor [p57Kip2] . Positive_regulation CDKN1C SKP1 12925736 1135311 Finally , the purified recombinant *mediated* [p57Kip2] ubiquitylation in vitro in a manner dependent on the presence of the cyclin E-CDK2 complex . Positive_regulation CDKN1C TFPT 11259850 796040 Conversely , *induced* expression of CDK inhibitors , p21 ( Waf1/Cip1 ) , p27 ( Kip1 ) , and [p57(Kip2)] in monkey kidney cells ( CV-1 ) . Positive_regulation CDKN1C TGFB1 10708569 673522 We previously uncovered that growth stimulation of rat primary osteoblasts by ( TGF-beta1 ) *resulted* in a dramatic decrease in [p57(Kip2)] , a member of cyclin dependent kinase (CDK) inhibitors , through the proteasomal degradation pathway ( Urano et al. , J. Biol. Chem. 274 , 12197-12200 , 1999 ) . Positive_regulation CDKN1C TP53 17045206 1635700 Whereas transactivates the retinoblastoma gene , p63 and p73 *induce* the [cyclin dependent kinase inhibitor p57] to maintain RB in an active , hypophosphorylated state . Positive_regulation CDKN1C TP63 17045206 1635701 Whereas p53 transactivates the retinoblastoma gene , and p73 *induce* the [cyclin dependent kinase inhibitor p57] to maintain RB in an active , hypophosphorylated state . Positive_regulation CDKN1C UROD 22654821 2522772 In approximately 20 % of patients , [BWS] *results* from chromosome 11 paternal , which causes dysregulation of imprinted growth regulation genes at 11p15.5 . Positive_regulation CDKN1C USO1 23470527 2750370 In fact , dependent *induction* of [p57(Kip2)] expression accounted for inhibitory effects on the actin cytoskeleton dynamics and thereby cancer cell motility . Positive_regulation CDKN2A EPHB2 12592382 1060412 These results suggested that activation of together with its downstream transcriptional machinery *mediated* p15(INK4b) and [p16(INK4a)] expression that led to HepG2 growth inhibition . Positive_regulation CDKN2A EPHB2 16014626 1453150 Hepatocyte growth factor induces redistribution of p21 ( CIP1 ) and p27 ( KIP1 ) through *dependent* [p16(INK4a)] up-regulation , leading to cell cycle arrest at G1 in HepG2 hepatoma cells . Positive_regulation CDKN2A EPHB2 21923753 2539127 We show that UVR induced signalling , mediated by BRAF , *regulates* p16 ( [CDKN2A] ) expression at the transcriptional , and possibly translational level . Positive_regulation CDKN2A ID1 11427735 831516 We also show that Id1 is able to directly *inhibit* p16/Ink4a but not [p19/ARF] promoter activity via its HLH domain , and that inhibits transcriptional activation at E-boxes within the p16/Ink4a promoter . Positive_regulation CDKN2B EPHB2 12592382 1060413 These results suggested that activation of together with its downstream transcriptional machinery *mediated* [p15(INK4b)] and p16(INK4a) expression that led to HepG2 growth inhibition . Positive_regulation CDKN2B FOXO1 16959612 1611257 We found the transcription factor C/EBPbeta to be essential for TGFbeta *induction* of the cell cycle inhibitor [p15INK4b] by a complex and repression of c-MYC by an E2F4/5-Smad complex in human epithelial cells . Positive_regulation CDX2 AGR2 22184114 2549416 Using two different cell lines in which *induces* expression of either the EGFR ligand amphiregulin or the transcription factor [CDX2] , only the highly conserved wild-type carboxyl-terminal KTEL motif results in the appropriate outcome . Positive_regulation CDX2 IL1B 20658368 2297958 [ Significance of *induced* ectopic expression of [CDX2] in the intestinal metaplasia of gastric epithelium ] . Positive_regulation CDX2 TNF 18507686 1958432 *induced* the expression of [CDX2] and MUC2 in cultured BEC . Positive_regulation CEACAM1 TNF 21329777 2453118 Our results demonstrated that [BGP] strongly *induced* the secretion of , IL-6 , IL-10 and IL-12 ; Positive_regulation CEACAM5 IL1B 12353224 993447 Our results show that after deposit of CTb into the CeA , the majority of double labeled cells were located in the PB and the PVT , suggesting that [CeA] cell *activation* by systemic is likely to arise predominantly from cell bodies located in these regions . Positive_regulation CEACAM5 RARB 9287985 452415 Furthermore , overexpression *resulted* in induction of cellular differentiation in xenografted tumors as evidenced by increased tumor cell expression of duct cell differentiation markers [carcinoembryonic antigen (CEA)] , CA19-9 , and cytokeratin 7 . Positive_regulation CEACAM5 TNF 8068303 269921 The expression of [CEA] on cultured endothelial cells can be *enhanced* by or IFN-gamma , and decreased by IL-4 . Positive_regulation CEACAM5 TNF 8453631 215211 Maximal *induction* of [CEA] by IFN-gamma and in the colon carcinoma cell line HT-29 occurs at 5-6 days with maximal secreted levels at 14 ng/ml for IFN-gamma and 20 ng/ml for TNF-alpha . Positive_regulation CEACAM6 CALM3 7654391 321153 However , depletion of extracellular calcium inhibited the release of [NCA] in *response* to both ETX and OZ . inhibitors , compound 48/80 and N- ( 6-aminohexyl ) -1 naphthalenesulfonamide ( W-7 ) , inhibited the release of NCA in response to a variety of endotoxin concentrations . Positive_regulation CEACAM6 CAV1 15047698 1244102 [CEACAM6] cross linking *induces* dependent , Src mediated focal adhesion kinase phosphorylation in BxPC3 pancreatic adenocarcinoma cells . Positive_regulation CEACAM6 CCL3 10695661 671398 Papa-NONOate , an NO donor , or a combination of xanthine and xanthine oxidase to generate superoxide , did not show an inhibitory effect on [NCA] and MCA *induced* by . Positive_regulation CEACAM6 CCL3 10695661 671399 In contrast , 3-morpholinosydnonimine ( SIN-1 ) , a peroxynitrite generator , elicited a concentration dependent reduction in [NCA] and MCA *induced* by . Positive_regulation CEACAM6 CSE 12738688 1149484 These data suggest that serine protease inhibitors attenuate the *induced* release of [NCA] and MCA from human fetal lung fibroblasts and that the inhibitory action of antiproteases might depend on NF-kappaB signaling pathway . Positive_regulation CEACAM6 FGFR3 1566862 186872 BEC released [NCA] and MCA in *response* to in a dose dependent and time dependent manner . Positive_regulation CEACAM6 FGFR3 1566862 186874 Nicotine , the nicotinic receptor antagonist d-tubocurarine , and the M2 receptor antagonist gallamine did not modulate the release of [NCA] in *response* to . Positive_regulation CEACAM6 IL2 15673626 1366322 Spontaneous and *induced* [NCA] , in vitro IL-2 and IL-12 secretion , and levels of plasma cortisol and urinary catecholamines were tested in daughters . Positive_regulation CEACAM6 IL2 15673626 1366323 Higher distressed daughters had lower *induced* [NCA] and decreased in vitro IL-2 and IL-12 secretion . Positive_regulation CEACAM6 IL8 10753876 682076 Papa-NONOate [ N- ( 3-ammoniopropyl ) -N- ( n-propyl ) amino ] diazen-1-ium-1 , 2-dialase or sodium nitroprusside , NO donors , or a combination of xanthine and xanthine oxidase to generate superoxide did not show an inhibitory effect on [NCA] *induced* by . Positive_regulation CEACAM6 NKX2-1 19329538 2080407 Knockdown of TTF-1 reduced hormone induction of [CEACAM6] by 80 % , and expression of recombinant *increased* CEACAM6 in a dose dependent fashion . Positive_regulation CEACAM6 PLA2G1B 7654391 321152 The lipoxygenase inhibitors , nordihydroguaiaretic acid and diethylcarbamazine , and inhibitors , mepacrine and dibucaine , *blocked* the release of [NCA] in response to ETX , OZ , calcium ionophore A23187 ( A23187 ) , and phorbol myristate acetate ( PMA ) . Positive_regulation CEACAM6 PRKACB 9689054 522718 Measurement of ATP dependent 45Ca2+ uptake into purified nuclei showed that phosphorylation *enhanced* the Ca2+ pumping activity of [NCA] . Positive_regulation CEACAM6 PRKACG 9689054 522719 Measurement of ATP dependent 45Ca2+ uptake into purified nuclei showed that phosphorylation *enhanced* the Ca2+ pumping activity of [NCA] . Positive_regulation CEACAM6 PRKAR1A 9689054 522720 Measurement of ATP dependent 45Ca2+ uptake into purified nuclei showed that phosphorylation *enhanced* the Ca2+ pumping activity of [NCA] . Positive_regulation CEACAM6 PRKAR1B 9689054 522721 Measurement of ATP dependent 45Ca2+ uptake into purified nuclei showed that phosphorylation *enhanced* the Ca2+ pumping activity of [NCA] . Positive_regulation CEACAM6 PRKAR2A 9689054 522722 Measurement of ATP dependent 45Ca2+ uptake into purified nuclei showed that phosphorylation *enhanced* the Ca2+ pumping activity of [NCA] . Positive_regulation CEACAM6 PRKAR2B 9689054 522723 Measurement of ATP dependent 45Ca2+ uptake into purified nuclei showed that phosphorylation *enhanced* the Ca2+ pumping activity of [NCA] . Positive_regulation CEBPA EPHB2 19587381 2129545 Inhibition of prevented induction of c-Fos by M-CSF and *reduced* [C/EBPalpha] phosphorylation and formation of colony forming unit-monocytes . Positive_regulation CEBPA EPHB2 19587381 2129551 In summary , M-CSF activates more potently than G-CSF , and thereby *induces* higher levels of c-Fos and [phospho-C/EBPalpha] ( S21 ) , which may directly interact to favor monopoiesis , whereas G-CSF activates signal transducer and activator of transcription 3 and SHP2 , potentially shifting the balance to granulopoiesis via gene induction by C/EBPalpha homodimers and via effects of SHP2 on regulators besides ERK . Positive_regulation CEBPA FOXO1 17090532 1660952 We propose that low expression of SIRT1 and *leads* to impaired [Foxo1-C/EBPalpha] complex formation , which contributes to the diminished adiponectin expression in obesity and type 2 diabetes . Positive_regulation CEBPA IL1B 18247123 1865220 Inhibition of IL-1beta mediated C3 promoter activation by the dominant negative mutant of p38-alpha mitogen activated protein kinase suggests that *induces* C3 expression through the activation of [C/EBP] . Positive_regulation CEBPA IL1B 18337234 1898214 Since *activates* NFkappaB , AP-1 and [C/EBP] , we over expressed these transcription factors alone and in combination and found that only NFkappaB alone increased FP mRNA expression . Positive_regulation CEBPA IL1B 9134219 427383 Moreover , staurosporine significantly augmented the *activation* of [C/EBP] by and forskolin . Positive_regulation CEBPA MAP2K6 10455174 638601 The selective inhibitors of , i.e. PD98059 and U0126 , *inhibit* LIF induced [C/EBP] gene expression and prevent adipocyte differentiation induced by LIF . Positive_regulation CEBPA MAP2K6 20127863 2248425 Furthermore , expression *activated* p38 and [C/EBPalpha] , increasing IGFBP-5 promoter activity and expression . Positive_regulation CEBPA TNF 10211885 607709 IL-4 and IL-13 decreased the *induced* [C/EBP] accumulation in a dose dependent manner , while IL-10 up-regulated its basal level . Positive_regulation CEBPA TNF 10623427 576189 All three cytokines inhibited *induced* [C/EBP] , but no true effect was noted for AP-1 and CREB in the presence of TNF-alpha . Positive_regulation CEBPA TNF 10838190 699577 Both cell-type- and stimulus-specific regulation of C/EBP mRNA expression and DNA binding activity were identified , with [C/EBPalpha] being *induced* by LPS , C/EBPbeta by LPS , IL-1 , and C/EBPdelta by LPS , IL-1 , IFN-gamma , TNF-alpha and PDGF . Positive_regulation CEBPA TNF 14572618 1155845 These results suggest that although *enhances* binding of [C/EBP] and NFkappaB complexes in NHBE cells , C/EBP binding seems to involve an oxidant dependent mechanism , whereas activation of NFkappaB complexes utilizes the ubiquitin-proteasome pathway , a mechanism that seems to be unaltered by the presence of antioxidants . Positive_regulation CEBPA TNF 23499548 2771997 Visfatin and/or *enhanced* [C/EBP] transcriptional activity and C/EBPa phosphorylation , which were suppressed by p38 mitogen activated protein kinase (MAPK) inhibition . Positive_regulation CEBPB CLU 10634518 576722 C/EBP-delta mRNA levels are low in nonsealed glands , but are rapidly and transiently induced in sealed glands by 24 h . [C/EBP-beta] mRNA expression is also relatively low in nonsealed glands , but is induced in sealed glands within 72 h. Expression of the apoptosis associated mRNAs encoding bax and is also *induced* in sealed glands by 24-48 h. Apoptosis and a moderate degree of tissue remodeling occur within the sealed glands in spite of systemic hormone levels capable of sustaining lactation . Positive_regulation CEBPB EPHB2 16453302 1540708 Interleukin-1 beta induction of matrix metalloproteinase-1 transcription in chondrocytes requires *dependent* activation of [CCAAT enhancer binding protein-beta] . Positive_regulation CEBPB EPHB2 17921324 1830336 Our data indicate that IL-17 induces MMP-1 in human cardiac fibroblasts directly via p38 MAPK- and dependent AP-1 , NF-kappaB , and [C/EBP-beta] *activation* and suggest that IL-17 may play a critical role in myocardial remodeling . Positive_regulation CEBPB EPHB2 21890597 2506389 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and *dependent* activation of the [CCAAT/enhancer binding protein beta] transcription factor independent of p53 . Positive_regulation CEBPB FOXO1 19026986 2017154 We found that *increased* the expression of CCAAT/enhancer binding protein ( [C/EBPbeta] , a positive regulator of monocyte chemoattractant protein (MCP)-1 and interleukin (IL)-6 genes , through directly binding to its promoter . Positive_regulation CEBPB IL1B 10594926 655133 Here we show that lipopolysaccharides (LPS) , , and TNFalpha *induce* the expression of the [c/ebpbeta] and -delta genes in mouse primary astrocytes . Positive_regulation CEBPB IL1B 10791956 714415 Induction of the transcription of secreted type IIA phospholipase A(2) gene by in chondrocytes absolutely *requires* [C/EBPbeta] and C/EBPdelta factors but does not involve NF-kappaB . Positive_regulation CEBPB IL1B 11035101 741057 These findings suggest that induces nuclear translocation of p50 containing dimers and that p50 interacts with [C/EBPbeta] *activated* by both IL-6 and IL-1beta to induce CRP expression . Positive_regulation CEBPB IL1B 11474579 841780 [C/EBPbeta] ( LAP and LIP isoforms ) was constitutively present in PVEC and was *induced* ( approximately 2-fold ) by IL-1beta , whereas C/EBPdelta was not constitutively expressed but was strongly induced by . Positive_regulation CEBPB IL1B 11854037 913419 *activates* [C/EBP-beta] and delta in human enterocytes through a mitogen activated protein kinase signaling pathway . Positive_regulation CEBPB IL1B 12072435 976040 *stimulated* the expression of [C/EBP beta] and -delta , and the direct binding of C/EBP beta to the C/EBP motif was confirmed . Positive_regulation CEBPB IL1B 15383601 1298976 Because can *induce* [C/EBPbeta] expression , the role of C/EBPbeta isoforms in IL-1beta regulation of alpha-SMA gene expression was investigated in rat lung myofibroblasts . Positive_regulation CEBPB IL1B 16453302 1540709 induction of matrix metalloproteinase-1 transcription in chondrocytes *requires* ERK dependent activation of [CCAAT enhancer binding protein-beta] . Positive_regulation CEBPB IL1B 16453302 1540717 stimulation of chondrocytes *increased* binding of [C/EBP-beta] to the MMP-1 C/EBP site . Positive_regulation CEBPB IL1B 16453302 1540718 Here we show that stimulation of chondrocytes *induced* phosphorylation of [C/EBP-beta] on threonine 235 , and that the ERK pathway inhibitor PD98059 reduced this phosphorylation . Positive_regulation CEBPB IL1B 20424162 2274556 also *causes* increased expression of [C/EBP-beta] and a reduction of MafA , NFATc2 , and Pdx-1 expression in beta cells . Positive_regulation CEBPB IL1B 9590244 504779 Finally , we show that both cAMP and strongly *induce* steady-state levels of [C/EBPbeta] and C/EBPdelta mRNA levels . Positive_regulation CEBPB NGFR 9603207 506754 In transactivation assays , [C/EBPbeta] activity was *stimulated* by signaling . Positive_regulation CEBPB TNF 10594926 655132 Here we show that lipopolysaccharides (LPS) , IL-1beta , and *induce* the expression of the [c/ebpbeta] and -delta genes in mouse primary astrocytes . Positive_regulation CEBPB TNF 11456275 838132 In fully differentiated adipocytes , rapidly *induced* [C/EBPbeta] and C/EBPdelta , whereas it downregulated the expression of C/EBPalpha and PPARgamma . Positive_regulation CEBPB TNF 12471036 1055491 We found basal binding of p300 , p50/p65 NF-kappaB , cyclic AMP regulatory element binding protein-2 , [CCAAT/enhancer binding protein beta] , and c-Jun. p50/p65 and p300 binding was selectively *increased* by . Positive_regulation CEBPB TNF 15758650 1380422 In turn , *stimulates* oxidative stress , NO synthesis , and phosphorylation of [C/EBP-beta] within its nuclear localization signal ( NLS ) . Positive_regulation CEBPB TNF 16754681 1590135 , levels of which are elevated in fat tissue with aging , *increased* CUGBP1 protein , CUGBP1 binding activity , and [C/EBPbeta-LIP] in preadipocytes from young rats . Positive_regulation CEBPB TNF 18040799 1669151 Similarly , *induced* the activation of [C/EBPbeta] and the expression of BDNF was sensitive to overexpression of DeltaC/EBPbeta ( a dominant negative mutant ) and ETO ( an inhibitor of C/EBPbeta ) . Positive_regulation CEBPB TNF 19088256 2024389 In conclusion , C/EBPalpha and C/EBPbeta control basal transcription , and *upregulates* 11beta-HSD1 , most likely by p38 MAPK mediated increased binding of [C/EBPbeta] to the human HSD11B1 promoter . Positive_regulation CEBPB TNF 19353522 2064838 We further found that , while either IFNgamma or alone *induced* minor expression of [C/EBPbeta] in MSCs , this transcription factor was dramatically upregulated when these cytokines were added together . Positive_regulation CEBPB TNF 19434061 2096506 Endogenous and *induced* expressions of IL-6 , IL-8 , p38 , p65 and [C/EBP-beta] were also downregulated by genistein , showing its anti-inflammatory properties . Positive_regulation CEBPB TNF 19530226 2109522 Binding of the NF kappaB p65 subunit and [C/EBP beta] to this element is *induced* by . Positive_regulation CEBPB TNF 20220144 2249423 In contrast to the murine NGAL orthologue , 24p3/lipocalin 2 , we found no *requirement* for [C/EBP-beta] or C/EBP-delta for NGAL induction by IL-17 and as neither small interfering RNAs against the two C/EBP mRNAs nor mutation of the C/EBP sites in the LCN2 promoter abolished IL-17- and TNF-alpha induced up-regulation of NGAL . Positive_regulation CEBPD IL1B 11278956 802952 Electromobility shift and supershift assays for a C/EBP motif in the PDGFalphaR promoter region revealed that PPARgamma activators suppressed *induced* DNA binding activity of [C/EBPdelta] and beta . Positive_regulation CEBPD IL1B 11278956 802954 PPARgamma activators also suppressed *induced* [C/EBPdelta] expression . Positive_regulation CEBPD IL1B 11474579 841781 C/EBPbeta ( LAP and LIP isoforms ) was constitutively present in PVEC and was induced ( approximately 2-fold ) by IL-1beta , whereas [C/EBPdelta] was not constitutively expressed but was strongly *induced* by . Positive_regulation CEBPD IL1B 17384995 1715890 In the in vitro study , *increased* [C/EBP-delta] mRNA levels in NS siRNA transfected MCs ( 7.3-fold ) , but no increase was evident in C/EBP-delta siRNA transfected MCs . Positive_regulation CEBPD TNF 11456275 838133 In fully differentiated adipocytes , rapidly *induced* C/EBPbeta and [C/EBPdelta] , whereas it downregulated the expression of C/EBPalpha and PPARgamma . Positive_regulation CEBPD TNF 20220144 2249426 In contrast to the murine NGAL orthologue , 24p3/lipocalin 2 , we found no *requirement* for C/EBP-beta or [C/EBP-delta] for NGAL induction by IL-17 and as neither small interfering RNAs against the two C/EBP mRNAs nor mutation of the C/EBP sites in the LCN2 promoter abolished IL-17- and TNF-alpha induced up-regulation of NGAL . Positive_regulation CEBPD TNF 9350999 460916 RT-PCR failed to detect the IL-1 transcript in TNFalpha treated HepG2 cells , suggesting that *activation* of [C/EBPdelta] by is not related to the IL-1 signalling pathway . Positive_regulation CEBPZ ADRB2 8945911 400358 After beta 1-adrenergic blockade ( atenolol , 1.0 mg/kg iv ) , selective activation with intracoronary bolus injections of pirbuterol ( 50 ng/kg ) *increased* [coronary blood flow (CBF)] by 95 +/- 19 % from 48.5 +/- 8.4 ml/min and external epicardial coronary diameter ( CD ) by 0.14 +/- 0.03 from 3.23 +/- 0.31 mm . Positive_regulation CEBPZ ARSA 22039321 2503452 Treatment with GTN , the NO donor , significantly inhibited the *induced* colonic lesions and increased [CBF] , while carboxy-PTIO or capsaicin-denervation counteracted the NO-ASA induced improvement of colonic healing and the accompanying increase in the CBF . Positive_regulation CEBPZ EDN2 2021480 157192 dose-dependently *increased* [CBF] , the maximal increase above the baseline value and EC50 being 32.3 +/- 4.0 % ( P less than 0.001 ) and 3 nM , respectively . Positive_regulation CEBPZ ETV7 19587307 2122623 *induces* changes in brain volume and [CBF] that can be predicted by using simple metrics . Positive_regulation CEBPZ FAS 11530940 853812 The FIRE3 mediated sterol response of the promoter *requires* [NF-Y/CBF] as a coactivator . Positive_regulation CEBPZ PLAT 22595494 2632259 administered within 4.5h of symptom onset *restores* [cerebral blood flow (CBF)] and promotes neurological recovery of stroke patients . Positive_regulation CEBPZ TNF 10824457 696243 *increased* [CBF] at relatively low concentrations ( 0.1 and 1 ng/ml ) and decreased CBF at a high concentration ( 10 ng/ml ) . Positive_regulation CEBPZ TNF 16854437 1638664 significantly *increased* [CBF] , which reached a maximum of 190 % of the baseline 1 h after the cessation of TNFalpha infusion . Positive_regulation CEL TNF 15811836 1392208 It reached the highest level at 21 hr and returned to the basal level by 42 hr. was significantly elevated only at 4 hr. ufCB *induced* significant increases of VEGF in [BAL] fluid throughout the study period , with the peak increase at 16 hr . Positive_regulation CEL TNF 17846063 1823051 [CEL-I] , an invertebrate N-acetylgalactosamine-specific C-type lectin , *induces* and G-CSF production by mouse macrophage cell line RAW264.7 cells . Positive_regulation CEL TNF 17846063 1823055 In this study , we found that [CEL-I] *induced* increased secretion of and granulocyte colony stimulation factor ( G-CSF ) by mouse macrophage cell line RAW264.7 cells in a dose dependent manner , whereas this cell line was highly resistant to CEL-I cytotoxicity . Positive_regulation CELF1 TNF 16754681 1590136 , levels of which are elevated in fat tissue with aging , *increased* CUGBP1 protein , [CUGBP1] binding activity , and C/EBPbeta-LIP in preadipocytes from young rats . Positive_regulation CEMP1 TNF 11038318 741648 [Cp23] stimulation also *induced* , IL-2 , and IL-5 mRNA production by spleen cells from infected animals . Positive_regulation CENPA STK39 18083840 1837062 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation CENPE STK39 18083840 1837077 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation CENPF STK39 18083840 1837092 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation CEP104 IFI27 11245420 792478 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP104 NGFR 15525794 1367282 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP112 IFI27 11245420 792514 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP112 NGFR 15525794 1367294 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP120 IFI27 11245420 792508 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP120 NGFR 15525794 1367292 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP128 IFI27 11245420 792472 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP128 NGFR 15525794 1367280 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP135 IFI27 11245420 792526 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP135 NGFR 15525794 1367298 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP152 IFI27 11245420 792532 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP152 NGFR 15525794 1367300 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP164 IFI27 11245420 792529 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP164 NGFR 15525794 1367299 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP170 IFI27 11245420 792517 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP170 NGFR 15525794 1367295 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP19 IFI27 11245420 792511 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP19 NGFR 15525794 1367293 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP192 IFI27 11245420 792487 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP192 NGFR 15525794 1367285 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP250 IFI27 11245420 792469 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP250 NGFR 15525794 1367279 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP290 IFI27 11245420 792520 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP290 NGFR 15525794 1367296 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP350 IFI27 11245420 792475 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP350 NGFR 15525794 1367281 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP41 IFI27 11245420 792412 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP41 NGFR 15525794 1367278 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP44 IFI27 11245420 792535 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP44 NGFR 15525794 1367301 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP55 IFI27 11245420 792409 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP55 NGFR 15525794 1367277 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP57 IFI27 11245420 792541 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP57 NGFR 15525794 1367303 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP63 IFI27 11245420 792499 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP63 NGFR 15525794 1367289 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP68 IFI27 11245420 792523 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP68 NGFR 15525794 1367297 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP70 IFI27 11245420 792538 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP70 NGFR 15525794 1367302 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP72 IFI27 11245420 792490 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP72 NGFR 15525794 1367286 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP76 IFI27 11245420 792493 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP76 NGFR 15525794 1367287 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP78 IFI27 11245420 792496 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP78 NGFR 15525794 1367288 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP85 IFI27 11245420 792484 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP85 NGFR 15525794 1367284 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP89 IFI27 11245420 792502 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP89 NGFR 15525794 1367290 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP95 IFI27 11245420 792481 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP95 NGFR 15525794 1367283 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CEP97 IFI27 11245420 792505 [CEP1612] , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation CEP97 NGFR 15525794 1367291 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that [CEP-11004] *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the . Positive_regulation CETP NR2F1 8530390 336877 Overexpression of ARP-1 or with CETP promoter/chloramphenicol acetyltransferase gene reporter plasmids *repressed* transcriptional activity of the [CETP] promoter containing sequences up to -300 , but activated transcription in the context of larger constructs containing sequences up to -636 . Positive_regulation CETP PCSK9 23307117 2725941 In this review , we discuss these promising therapies , which include inhibitors , apolipoprotein B antisense oligonucleotides , microsomal transfer protein inhibitors , thyroid mimetics , and [cholesteryl ester transfer protein] *inhibitors* . Positive_regulation CFB TNF 22326848 2580630 In contrast , *induced* [Cfb] gene expression was not deficient in MyD88 ( -/- ) cardiomyocytes . Positive_regulation CFHR1 TNF 19190237 2061274 The binding of ACh was higher in patients with COPD and in control smokers than in controls and in CSE treated than in IL-1beta- and *stimulated* [HFL-1] cells . Positive_regulation CFI CALCR 22290438 2565108 [CFI] recruitment to this defined region may *result* from simultaneous binding to the Spt5 , to nascent RNA containing the pA sequence , and to the elongating Pol II isoform that is phosphorylated at serine 2 ( S2 ) residues in its C-terminal domain (CTD) . Positive_regulation CFI CPSF1 11713271 880837 In Saccharomyces cerevisiae , in vitro mRNA cleavage and *require* the poly ( A ) binding protein , Pab1p , and two multiprotein complexes : [CFI] ( cleavage factor I ) and CPF ( cleavage and polyadenylation factor ) . Positive_regulation CFI CPSF2 11713271 880838 In Saccharomyces cerevisiae , in vitro mRNA cleavage and *require* the poly ( A ) binding protein , Pab1p , and two multiprotein complexes : [CFI] ( cleavage factor I ) and CPF ( cleavage and polyadenylation factor ) . Positive_regulation CFI CPSF3 11713271 880839 In Saccharomyces cerevisiae , in vitro mRNA cleavage and *require* the poly ( A ) binding protein , Pab1p , and two multiprotein complexes : [CFI] ( cleavage factor I ) and CPF ( cleavage and polyadenylation factor ) . Positive_regulation CFI CSTF1 11713271 880840 In Saccharomyces cerevisiae , in vitro mRNA cleavage and *require* the poly ( A ) binding protein , Pab1p , and two multiprotein complexes : [CFI] ( cleavage factor I ) and CPF ( cleavage and polyadenylation factor ) . Positive_regulation CFI CSTF2 11713271 880841 In Saccharomyces cerevisiae , in vitro mRNA cleavage and *require* the poly ( A ) binding protein , Pab1p , and two multiprotein complexes : [CFI] ( cleavage factor I ) and CPF ( cleavage and polyadenylation factor ) . Positive_regulation CFI CSTF3 11713271 880842 In Saccharomyces cerevisiae , in vitro mRNA cleavage and *require* the poly ( A ) binding protein , Pab1p , and two multiprotein complexes : [CFI] ( cleavage factor I ) and CPF ( cleavage and polyadenylation factor ) . Positive_regulation CFI IL6 9804975 544631 The *induced* increase in [CFI] gene expression was inhibited by actinomycin D indicating regulatory effects at the level of transcription . Positive_regulation CFI IL6 9804975 544632 Our results indicate that the *upregulation* of [CFI] gene expression by involves a coordinate effort at the level of transcription and mRNA stability , with the enhanced rate of transcription being the principal mechanism . Positive_regulation CFI MET 7180941 25021 Infusion of saline , albumin , or the synthetic chemotactic peptide did not *cause* elevation of the serum [CFI] levels in rabbits . Positive_regulation CFI MTPAP 11716503 881712 The glutathione S-transferase pull-down assay and the immunoprecipitation experiment revealed that directly interacts with CFI-25 and that the C-terminal 69 residues of PAP and the N-terminal 60 residues of CFI-25 are *sufficient* for the interaction between [CFI-25] and PAP . Positive_regulation CFI SYMPK 11713271 880836 In Saccharomyces cerevisiae , in vitro mRNA cleavage and *require* the poly ( A ) binding protein , Pab1p , and two multiprotein complexes : [CFI] ( cleavage factor I ) and CPF ( cleavage and polyadenylation factor ) . Positive_regulation CFL1 EPHB2 19553453 2099478 Further , we found that *mediated* regulation of [cofilin] activity at least partially depends on the activation of Rho associated kinase (ROCK) and LIMK-1 . Positive_regulation CFL1 EPHB2 20610540 2309737 LHR dependent Rho inactivation and subsequent activation of [cofilin] does not *involve* , epidermal growth factor receptor , or phosphatidylinositol 3-kinase pathways downstream of PKA . Positive_regulation CFL1 IL1B 15467300 1335165 Inhibition of ROCK ( Y-27632 , 10 muM ) reduced only the *stimulated* LIMK2 and [cofilin] expression . Positive_regulation CFL1 IL1B 15467300 1335172 These novel observations in PASMCs indicate that LIMK2 and [cofilin] expression can be *induced* by PDGF or . Positive_regulation CFL2 EPHB2 19553453 2099483 Further , we found that *mediated* regulation of [cofilin] activity at least partially depends on the activation of Rho associated kinase (ROCK) and LIMK-1 . Positive_regulation CFL2 EPHB2 20610540 2309740 LHR dependent Rho inactivation and subsequent activation of [cofilin] does not *involve* , epidermal growth factor receptor , or phosphatidylinositol 3-kinase pathways downstream of PKA . Positive_regulation CFL2 IL1B 15467300 1335168 Inhibition of ROCK ( Y-27632 , 10 muM ) reduced only the *stimulated* LIMK2 and [cofilin] expression . Positive_regulation CFL2 IL1B 15467300 1335173 These novel observations in PASMCs indicate that LIMK2 and [cofilin] expression can be *induced* by PDGF or . Positive_regulation CFLAR FAS 15282307 1277709 c-Flip , along with Raf-1 , is part of a K8/K18 immunoisolated complex from wild-type hepatocytes , and stimulation *leads* to further [c-Flip] and Raf-1 recruitment in the complex . Positive_regulation CFLAR FAS 16403915 1554035 Using an inducible system we demonstrated that both resistance toward *mediated* apoptosis and induction of [c-FLIP] are dependent on Tax . Positive_regulation CFLAR FAS 18790746 1963554 Mitogen activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of [c-FLIP-s] levels and *activation* of . Positive_regulation CFLAR FAS 19228791 2054588 Inhibition of PI3K/Akt pathway did not modify the difference between PARP-1-competent or -deficient FLS in *mediated* apoptosis or [c-FLIP-S] expression . Positive_regulation CFLAR FOXO1 19470406 2097446 Down-regulation of *dependent* [c-FLIP] expression mediates TRAIL induced apoptosis in activated hepatic stellate cells . Positive_regulation CFLAR TGM2 21525012 2439794 TGM2 mediated TRAIL resistance is likely through c-FLIP because suppression significantly *reduced* [c-FLIP] but not Mcl-1 expression . Positive_regulation CFLAR TNF 10894163 711505 NF-kappaB and JNK/SAPK activation is intact in *stimulated* [casper-/-] cells . Positive_regulation CFLAR TNF 11359904 816570 Treatment of SV80 cells with the proteasome inhibitor N-benzoyloxycarbonyl ( Z ) -Leu-Leu-leucinal ( MG-132 ) or geldanamycin , a drug interfering with tumor necrosis factor (TNF) induced NF-kappaB activation , inhibited *induced* upregulation of [cFLIP] . Positive_regulation CFLAR TNF 12861043 1111706 [cFLIP] expression was *increased* by , TRAIL , or vascular endothelial growth factor but decreased by wortmannin , indicating that cFLIP expression is regulated by both the NF-kappaB and phosphatidylinostiol-3 kinase (PI-3)/Akt pathways . Positive_regulation CFLAR TNF 15223828 1264860 c-IAP1 expression was not affected by TNF-alpha or mutant I kappa B , and mutant I kappa B abolished *induced* [c-FLIP] induction in RPE cells . Positive_regulation CFLAR TNF 15851579 1399554 Overexpression of mutant IkappaB blocked *induced* TRAF-1 , TRAF-2 , c-IAP1 , c-IAP2 , [c-FLIP] , and A1 gene expression and downregulated TRAF-1 protein levels . Positive_regulation CFLAR TNF 17942934 1814223 The *induction* of various antiapoptotic gene products ( MMP-9 , cyclin D1 , COX-2 , IAP1 , IAP2 , Bcl-2 , [cFLIP] , and XIAP ) by was also abolished in NQO2-/- cells . Positive_regulation CFLAR TNF 20378831 2273549 The *induction* of the chemokine interleukin-8 and the antiapoptotic protein [cFLIP] by were markedly less in HCT116 cells lacking DNMT than in parental cells . Positive_regulation CFLAR TNFSF10 12861043 1111707 [cFLIP] expression was *increased* by TNF-alpha , , or vascular endothelial growth factor but decreased by wortmannin , indicating that cFLIP expression is regulated by both the NF-kappaB and phosphatidylinostiol-3 kinase (PI-3)/Akt pathways . Positive_regulation CFLAR TNFSF10 20137126 2208047 *induced* apoptosis in RPMI8226 cells , the expression level of genes bcl-2 , mcl-1 , CARP1 , CARP2 , XIAP and [cFLIP] decreased , while the expression level of Bax increased , but the expression level of caspase-3 and NF-kappaB P65 ( RelA ) proteins decreased . Positive_regulation CFP ARSA 6367021 35454 It is suggested that the modulation of the [PFC] response *induced* by and ST is mediated by the prostaglandin system . Positive_regulation CFP EPHB2 24380761 2911936 Following the fifth apomorphine injection , significantly *increased* in the [PFC] , decreased in the amygdala but was unchanged in the LH and NAcc . Positive_regulation CFP IL1B 9829620 551116 AA-2G synergistically stimulated the anti-SRBC [PFC] responses in the *presence* of , IL-2 , IL-5 or CAS , IL-1beta among these cytokines being most highly affected . Positive_regulation CFP TCN1 3159691 48952 given in vivo *enhanced* primary [PFC] responses to the T-independent antigen DNP-Ficoll by greater than 700 % + . Positive_regulation CFP TNF 16857767 1600442 Using isolated ATII-cells , it was studied whether [PFC] prevent C. pneumoniae *induced* and MIP-2 release and what the underlying pathway is . Positive_regulation CFTR ADRB2 7522902 243726 Activation of the coexpressed increased cAMP and *led* to [CFTR] activation . Positive_regulation CFTR CAPN8 21111762 2372174 Inhibition of intracellular activity *prevents* [CFTR] degradation and leads to a 10-fold increase in the level of F508del-CFTR at the plasma membrane , further indicating the involvement of calpain activity in the maintenance of very low levels of mature channel form . Positive_regulation CFTR EPHB2 15304546 1322352 Furthermore , activation of by the coexpression of constitutively active MAPKK/MEK predominantly *augmented* the expression of [wt-CFTR] , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation CFTR IL1B 10657593 664038 *regulates* [CFTR] expression in human intestinal T84 cells . Positive_regulation CFTR IL1B 10657593 664041 These results suggest that some PKC isoform ( s ) and at least a PTK might be involved in the [CFTR] up-regulation *induced* by . Positive_regulation CFTR IL1B 11114294 786554 NF-kappa B mediates *up-regulation* of [CFTR] gene expression in Calu-3 cells by . Positive_regulation CFTR IL1B 11278608 802690 The stimulation of [CFTR] , *induced* by , was also blocked in the presence of the dominant negative mutant . Positive_regulation CFTR IL1B 14527933 1185875 *increased* [CFTR] mRNA levels without affecting those for ENaC subunits . Positive_regulation CFTR MAP2K6 15304546 1322358 Furthermore , activation of ERK/MAPK by the coexpression of constitutively active predominantly *augmented* the expression of [wt-CFTR] , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation CFTR OSR1 15767308 1384039 We present a model for rapid control of CFTR and NKCC in chloride cells that includes : ( 1 ) *activation* of NKCC and [CFTR] via cAMP/PKA , ( 2 ) activation of NKCC by PKC , myosin light chain kinase (MLCK) , p38 , and SPAK , ( 3 ) deactivation of NKCC by hypotonic cell swelling , Ca ( 2+ ) and an as yet unidentified protein phosphatase and ( 4 ) involvement of protein tyrosine kinase (PTK) acting on FAK to set levels of NKCC activity . Positive_regulation CFTR TGM2 18490773 1917071 We have shown that a defective [CFTR] *induces* a remarkable up-regulation of ( TG2 ) in both tissues and cell lines . Positive_regulation CGA EPHB2 18558406 1940731 More importantly , the present study suggests that GnRH induced [gonadotropin] subunit gene expression and LH release *involve* signaling in goldfish . Positive_regulation CGA EPHB2 22374973 2581752 Taken together , the results indicate that mRFRP function as GnIH to *inhibit* GnRH induced [gonadotropin] subunit gene transcriptions by inhibiting adenylate cyclase/cAMP/protein kinase A-dependent activation in LßT2 cells . Positive_regulation CGA IL1B 10342859 616530 [Gonadotropin] *stimulation* and concurrent treatment with PGE2 or resulted in ovulation of COX-2 ( -/- ) mice comparable to that in COX-2 ( +/+ ) , whereas treatment with PGF2alpha was less effective . Positive_regulation CGA IL1B 1517367 196847 Rapid *stimulation* of human chorionic [gonadotropin] secretion by from perifused first trimester trophoblast . Positive_regulation CGA IL1B 15373762 1297874 *induced* expression of IL-6 and production of human chorionic [gonadotropin] in human trophoblast cells via nuclear factor-kappaB activation . Positive_regulation CGA IL6R 7559874 324105 Soluble in the sera of pregnant women forms a complex with IL-6 and *augments* human chorionic [gonadotropin] production by normal human trophoblasts through binding to the IL-6 signal transducer . Positive_regulation CGA LHX4 17667940 1858069 Using LHX4 chromatin immunoprecipitation and CGA-promoter assays , we found that endogenous LHX4 binds to the CGA promoter and that mediated [CGA] *activation* is enhanced by the SS18-SSX protein , but not by the SSX protein . Positive_regulation CGA MAP2K6 18558406 1940738 More importantly , the present study suggests that GnRH induced [gonadotropin] subunit gene expression and LH release *involve* signaling in goldfish . Positive_regulation CGA NT5E 6094284 42944 [Thyrotropin] *increases* <5'-nucleotidase> activity in primary cultures of porcine thyroid cells . Positive_regulation CGA PLAT 16514196 1530784 The results suggest that [gonadotropin] surge *induced* regulation of tissue inhibitor of metalloproteinase-4 and may be prostanoid dependent , and support a potential role for increased tissue plasminogen activator expression and decreased tissue inhibitor of metalloproteinase-4 expression in the mechanism of ovulation . Positive_regulation CGA PLAU 11967205 933108 [Gonadotropin] surge *induced* up-regulation of the plasminogen activators ( tissue plasminogen activator and urokinase plasminogen activator ) and the receptor within bovine periovulatory follicular and luteal tissue . Positive_regulation CGA TF 8706718 373461 The transcription of the gene is *induced* by [follitropin] via cAMP in rat Sertoli cells . Positive_regulation CGA TNF 15342341 1353764 We compared the potency of CGA with that of beta-amyloid ( betaA ) under identical conditions and found that [CGA] *induces* 5-7 times greater NO and secretion . Positive_regulation CGA TNF 1727819 180931 Trophoblast derived *induces* release of human chorionic [gonadotropin] using interleukin-6 (IL-6) and IL-6-receptor dependent system in the normal human trophoblasts . Positive_regulation CGA TNF 9603942 507058 [CGA] also *induced* a marked accumulation of nitric oxide and by microglia , but we could not establish a direct correlation between the levels of nitric oxide and tumor necrosis factor-alpha and the neuronal damage . Positive_regulation CGB8 EPHB2 18558406 1940722 More importantly , the present study suggests that GnRH induced [gonadotropin] subunit gene expression and LH release *involve* signaling in goldfish . Positive_regulation CGB8 EPHB2 22374973 2581751 Taken together , the results indicate that mRFRP function as GnIH to *inhibit* GnRH induced [gonadotropin] subunit gene transcriptions by inhibiting adenylate cyclase/cAMP/protein kinase A-dependent activation in LßT2 cells . Positive_regulation CGB8 IL1B 10342859 616529 [Gonadotropin] *stimulation* and concurrent treatment with PGE2 or resulted in ovulation of COX-2 ( -/- ) mice comparable to that in COX-2 ( +/+ ) , whereas treatment with PGF2alpha was less effective . Positive_regulation CGB8 IL1B 1517367 196846 Rapid *stimulation* of human chorionic [gonadotropin] secretion by from perifused first trimester trophoblast . Positive_regulation CGB8 IL1B 15373762 1297873 *induced* expression of IL-6 and production of human chorionic [gonadotropin] in human trophoblast cells via nuclear factor-kappaB activation . Positive_regulation CGB8 IL6R 7559874 324104 Soluble in the sera of pregnant women forms a complex with IL-6 and *augments* human chorionic [gonadotropin] production by normal human trophoblasts through binding to the IL-6 signal transducer . Positive_regulation CGB8 MAP2K6 18558406 1940729 More importantly , the present study suggests that GnRH induced [gonadotropin] subunit gene expression and LH release *involve* signaling in goldfish . Positive_regulation CGB8 PLAT 16514196 1530782 The results suggest that [gonadotropin] surge *induced* regulation of tissue inhibitor of metalloproteinase-4 and may be prostanoid dependent , and support a potential role for increased tissue plasminogen activator expression and decreased tissue inhibitor of metalloproteinase-4 expression in the mechanism of ovulation . Positive_regulation CGB8 PLAU 11967205 933106 [Gonadotropin] surge *induced* up-regulation of the plasminogen activators ( tissue plasminogen activator and urokinase plasminogen activator ) and the receptor within bovine periovulatory follicular and luteal tissue . Positive_regulation CGB8 TNF 1727819 180930 Trophoblast derived *induces* release of human chorionic [gonadotropin] using interleukin-6 (IL-6) and IL-6-receptor dependent system in the normal human trophoblasts . Positive_regulation CGN TNF 20937806 2353620 induced the ubiquitination of TRAF2 ( TNF receptor associated factor 2 ) , which interacts with NIK , and [CGN] *induced* phosphorylation of BCL10 , leading to increased NIK phosphorylation . Positive_regulation CH25H TLR7 20699362 2351547 In vitro experiments using a panel of TLR agonists to activate BMDCs and macrophages demonstrated that [Ch25h] expression is *induced* rapidly , selectively , and robustly by the ligands poly I:C and LPS . Positive_regulation CHAT IL1B 16122837 1454396 In the *presence* of Abeta also increased [ChAT] activity ( 47 % ) , ACh release ( 100 % ) but had no effect on acetyl-CoA distribution and cell viability . Positive_regulation CHAT ITGAL 12098504 961532 By 48 h , however , the ACh content had increased as compared to control due to up-regulation of [ChAT] expression *mediated* by . Positive_regulation CHAT NT5E 7867750 287374 As a single factor produced the greatest *increase* in [ChAT] activity , but was not additive with any other neurotrophin or CNTF . Positive_regulation CHAT NT5E 7869082 296553 Both BDNF and *attenuate* the loss of [ChAT] expression in axotomized RDLN motor neurons ; Positive_regulation CHAT TNF 19190237 2061271 IL-1beta increased the ChAT and M ( 3 ) , down-regulated M ( 2 ) , and CSE *increased* [ChAT] and M ( 3 ) expression while down regulating the expression of M ( 2 ) in HFL-1 cells . Positive_regulation CHD4 IL1B 16847181 1588123 The messenger RNA expressions of [LARC] ( liver and activation regulated chemokine ) , GMCSF ( granulocyte-macrophage colony stimulating factor ) , epiregulin , ICAM1 ( intercellular adhesion molecule 1 ) , and TGFA ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation CHEK2 SPHK1 23576579 2799911 The overexpressed *led* to increased [checkpoint kinase 2] and enhanced HuR phosphorylation which allowed for increased translation of c-Myc mRNA through HuR binding at the 3'-untranslated regions . Positive_regulation CHGA IL1B 10477397 642953 IFN-gamma decreased the *induced* [SPI-3] expression in wt islets or beta-cells , but induced a 5-fold increase in the expression of this mRNA in IRF-1-/- islets cells , suggesting that IRF-1 mediates an inhibitory effect of IFN-gamma on SPI-3 expression . Positive_regulation CHGA IL1B 10547273 564731 *induces* [serine protease inhibitor 3 (SPI-3)] gene expression in rat pancreatic beta-cells . Positive_regulation CHGA IL1B 9690661 523070 We find that and IL-6 *increase* the cellular content and [chromogranin A] secretion by LNCaP and DU-145 cells . Positive_regulation CHGA MAP2K6 10197763 604886 Expression of constitutively activated Ras , Raf or mutants *increased* [chromogranin A] promoter activity . Positive_regulation CHGA TNF 18719026 1984923 *inhibits* serine protease inhibitor 2.1 ( [Spi] 2.1 ) and IGF-I gene expression by GH in CWSV-1 hepatocytes . Positive_regulation CHGA TNF 21462331 2412864 This study also showed that *induced* [SPI-3] mRNA expression in HT-29 human colon cancer cells , and vitamin B6 ( pyridoxal hydrochloride ) pretreatment of HT-29 cells inhibited TNF -induced mRNA expression of SPI-3 . Positive_regulation CHI3L1 AVP 16488162 1567665 Both PTHrP ( 1-34 ) and *increased* [YKL-40] secretion from RA chondrocytes . Positive_regulation CHI3L1 CD28 7533092 292214 Taken together , these data demonstrate that the antigen induced expression of [gp39] is *dependent* on TCR derived signals , yet independent of co-stimulatory signals . Positive_regulation CHI3L1 CTLA4 7533092 292215 Taken together , these data demonstrate that the antigen induced expression of [gp39] is *dependent* on TCR derived signals , yet independent of co-stimulatory signals . Positive_regulation CHI3L1 IFNG 16357325 1539699 In contrast , expression of [YKL-40] was *induced* by and suppressed by dexamethasone . Positive_regulation CHI3L1 IL6 21478032 2434028 , but not TNF-a , *increases* plasma [YKL-40] in human subjects . Positive_regulation CHI3L1 IL6 21478032 2434032 To study the possible *role* of and tumor necrosis factor (TNF)-a in the regulation of [YKL-40] plasma levels , we included healthy men , who received either recombinant human ( rh ) IL-6 ( n=6 ) , rhTNF-a ( n=8 ) or vehicle ( n=7 ) for 3h . Positive_regulation CHI3L1 IL6 24570843 2919776 Recombinant human *induced* a donor dependent change in mineralization and significantly promoted [YKL-40] protein secretion . Positive_regulation CHI3L1 IL8 23197259 2718270 [YKL-40] *induces* expression from bronchial epithelium via MAPK ( JNK and ERK ) and NF-?B pathways , causing bronchial smooth muscle proliferation and migration . Positive_regulation CHI3L1 MAPK1 23755018 2797710 In addition , [YKL-40] *induces* signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation CHI3L1 MAPK10 23755018 2797711 In addition , [YKL-40] *induces* signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation CHI3L1 MAPK11 23755018 2797712 In addition , [YKL-40] *induces* signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation CHI3L1 MAPK12 23755018 2797713 In addition , [YKL-40] *induces* signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation CHI3L1 MAPK13 23755018 2797714 In addition , [YKL-40] *induces* signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation CHI3L1 MAPK14 23755018 2797715 In addition , [YKL-40] *induces* signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation CHI3L1 MAPK15 23755018 2797709 In addition , [YKL-40] *induces* signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation CHI3L1 MAPK3 23755018 2797716 In addition , [YKL-40] *induces* signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation CHI3L1 MAPK4 23755018 2797717 In addition , [YKL-40] *induces* signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation CHI3L1 MAPK6 23755018 2797718 In addition , [YKL-40] *induces* signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation CHI3L1 MAPK7 23755018 2797719 In addition , [YKL-40] *induces* signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation CHI3L1 MAPK8 23755018 2797720 In addition , [YKL-40] *induces* signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation CHI3L1 MAPK9 23755018 2797721 In addition , [YKL-40] *induces* signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation CHI3L1 MATN1 24055693 2888231 We found that the quantity of IL-6 , but not TNF-a or [CHI3L1] , *induced* by was significantly correlated with plasma IL-6 , BMI , waist/hip circumferences , fasting plasma insulin , and insulin resistance . Positive_regulation CHI3L1 NFATC2 8530342 336859 These results suggest that , via binding to at least two cis-elements , is *essential* for the induction of [gp39] gene expression in response to T cell activation . Positive_regulation CHI3L1 OSM 21953450 2507274 Activation of STAT3 by *induced* [YKL-40] expression in astrocytes , whereas expression of a dominant negative STAT3 had a suppressive effect . Positive_regulation CHI3L1 PTHLH 16488162 1567666 Both ( 1-34 ) and AVP *increased* [YKL-40] secretion from RA chondrocytes . Positive_regulation CHI3L1 STAT3 21953450 2507273 Activation of by oncostatin M *induced* [YKL-40] expression in astrocytes , whereas expression of a dominant negative STAT3 had a suppressive effect . Positive_regulation CHI3L1 STAT3 22081431 2574717 During second phase involution , [chitinase 3-like 1] , which has been associated with wound healing and chronic inflammatory conditions , is dramatically *up-regulated* by . Positive_regulation CHI3L1 TNF 18802121 1965051 *stimulated* [YKL-40] synthesis in alveolar macrophages from smokers with COPD , and exposure of these cells to YKL-40 promoted the release of IL-8 , MCP-1 , MIP-1alpha , and metalloproteinase-9 . Positive_regulation CHI3L1 TNF 21478032 2434027 IL-6 , but not , *increases* plasma [YKL-40] in human subjects . Positive_regulation CHI3L1 TNF 21478032 2434031 To study the possible *role* of interleukin-6 (IL-6) and in the regulation of [YKL-40] plasma levels , we included healthy men , who received either recombinant human ( rh ) IL-6 ( n=6 ) , rhTNF-a ( n=8 ) or vehicle ( n=7 ) for 3h . Positive_regulation CHI3L2 IL1B 18240213 1871410 and TNFalpha *caused* increased release of chitinase 3-like protein 1 (CHI3L1) , [CHI3L2] , complement factor B , matrix metalloproteinase 3 , ECM-1 , haptoglobin , serum amyloid A3 , and clusterin . Positive_regulation CHI3L2 TNF 18240213 1871409 IL-1beta and *caused* increased release of chitinase 3-like protein 1 (CHI3L1) , [CHI3L2] , complement factor B , matrix metalloproteinase 3 , ECM-1 , haptoglobin , serum amyloid A3 , and clusterin . Positive_regulation CHKA TFPI2 21921034 2506884 A comparable *role* for in the regulation of [Chk1] phosphorylation was also observed in human cells . Positive_regulation CHST2 TNF 15728736 1416821 Expression of N-acetylglucosamine 6-O-sulfotransferases ( GlcNAc6STs ) -1 and -4 in human monocytes : [GlcNAc6ST-1] is implicated in the generation of the 6-sulfo N-acetyllactosamine/Lewis x epitope on CD44 and is *induced* by . Positive_regulation CHST2 TNF 15728736 1416823 However , only [GlcNAc6ST-1] was *induced* by in the human SR91 cell line , which also up-regulated the AG107 epitope . Positive_regulation CHUK CCND1 16260626 1478093 Constitutively active [IKKalpha] *induced* p52 , RelB , and in untransformed mammary epithelial cells . Positive_regulation CHUK CCND1 18792914 2008959 Moreover , the soluble nickel induced degradation is dependent on its Thr286 residue and *requires* [IKKalpha] , but not HIF-1alpha , which are both reported to be involved in cyclin D1 down-regulation . Positive_regulation CHUK CST6 21182083 2373760 plus IFN-? *activated* the [IKK complex] to induce phosphorylation mediated degradation of p105 , the physiological partner and inhibitor of the MEK kinase , tumor progression locus 2 (Tpl-2) . Positive_regulation CHUK CTGF 19301259 2064251 Stimulation of JJ012 cells with also *induced* [IkappaB kinase alpha/beta] ( IKK alpha/beta ) phosphorylation , IkappaBalpha phosphorylation , p65 Ser ( 536 ) phosphorylation , and kappaB-luciferase activity . Positive_regulation CHUK EPHB2 23563696 2794488 Induction in gastric mucosal prostaglandin and nitric oxide by Helicobacter pylori is dependent on *mediated* activation of [IKK-ß] and cPLA2 : modulatory effect of ghrelin . Positive_regulation CHUK EPHB2 9689078 522735 We have previously shown that mitogen activated protein kinase kinase 1 ( MEKK1 ) can *induce* both this site-specific phosphorylation of IkappaB alpha at Ser-32 and Ser-36 in vivo and the activity of a high molecular weight [IkappaB kinase complex] in vitro . Positive_regulation CHUK FAS 20212524 2223116 We validated experimentally that stimulation *resulted* in an interaction of p43-FLIP with the [IKK complex] followed by its activation . Positive_regulation CHUK IL1B 10391945 626979 However , [IKK] activity was strongly *induced* by TNF-alpha but not by . Positive_regulation CHUK IL1B 11275558 797840 Immunoblot analysis involving anti-IkappaB kinase (IKK)-alpha and anti-phosphoserine antibodies revealed that N2733 inhibited *induced* [IKK-alpha] phosphorylation , whereas N2733 had no inhibitory effect on IL-1beta stimulated p42/p44 MAP kinase or p38 MAP kinase activity . Positive_regulation CHUK IL1B 11976320 953885 In human embryonic kidney 293 cells , *induces* [IkappaB kinase beta (IKKbeta)] activation , IkappaBalpha degradation , NF-kappaB transactivation , and weak Akt activation . Positive_regulation CHUK IL1B 11976320 953958 Furthermore , a dominant negative mutant of Akt abolishes IKKbeta inhibition by CaMKKc and ionomycin , suggesting that Akt acts as a mediator of CaMKK signaling to inhibit *induced* [IKK] activity at an upstream target site . Positive_regulation CHUK IL1B 14764725 1207377 Antioxidant treatment of LPS stimulated neutrophils also inhibited the production of proinflammatory cytokines ( TNF-alpha , macrophage inflammatory protein-2 , and ) , as well as *activation* of the kinases [IkappaB kinase alpha] , IkappaB kinase beta , p38 , Akt , and extracellular receptor activated kinases 1 and 2 . Positive_regulation CHUK IL1B 15077173 1265808 Short-time inhibition of Hsp90 resulted in impaired [IKK] kinase *activation* by TNFalpha , or phorbolester PMA . Positive_regulation CHUK IL1B 15304320 1284621 15-Deoxy-delta ( 12,14 ) -prostaglandin J ( 2 ) inhibits *induced* [IKK] enzymatic activity and IkappaBalpha degradation in rat chondrocytes through a PPARgamma independent pathway . Positive_regulation CHUK IL1B 15550384 1360966 Iron mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha induced but not *induced* [IkappaB kinase complex/nuclear] factor-kappaB activation . Positive_regulation CHUK IL1B 15550384 1360977 Cleavage and degradation of TNF pathway components TNFR1 , RIP , and Hsp90 were observed in l-mimosine and H ( 2 ) O ( 2 ) treated cells indicating a putative mechanism for selective inhibition of TNF but not *induced* [IKK] activation . Positive_regulation CHUK IL1B 16354686 1504428 Clearance of both superoxide and H2O2 from within the endosomal compartment significantly abrogated *dependent* [IKK] and NF-kappaB activation . Positive_regulation CHUK IL1B 19854138 2155747 A ubiquitin replacement strategy in human cells reveals distinct mechanisms of [IKK] *activation* by TNFalpha and . Positive_regulation CHUK IL1B 19854138 2155755 We demonstrate that K63 of ubiquitin and the catalytic activity of Ubc13 , an E2 that catalyzes K63 polyubiquitination , are required for [IKK] *activation* by , but surprisingly , not by TNFalpha . Positive_regulation CHUK IL1B 20038579 2205268 Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and *induced* [IKK/NF-kappaB] and JNK/AP-1 activation . Positive_regulation CHUK MAP2K6 16584774 1665806 Together , we interpret these data as demonstrating that the activation caused by loss of Gimap5 is a cell intrinsic phenomenon caused , in part , by a dependent *activation* of [IKK] . Positive_regulation CHUK MAP2K6 24466036 2907702 In addition , activation of NF?B via the MAPK pathway is regulated through induced *activation* of [IKK] . Positive_regulation CHUK TGM2 16987813 1640585 Recently we reported that *activates* nuclear factor-kappaB (NF-kappaB) [independently of I-kappaB kinase (IKK)] activation , by inducing cross linking and protein polymer formation of inhibitor of nuclear factor-kappaBalpha ( I-kappaBalpha ) . Positive_regulation CHUK TLR7 22473004 2589047 NLRC5 ablation reduces MHC class I expression , and enhances [IKK] and IRF3 phosphorylation in *response* to stimulation or viral infection . Positive_regulation CHUK TNF 10195894 603987 In mammalian cells , phosphorylation of two sites at the activation loop of IKKbeta was essential for *activation* of [IKK] by and interleukin-1 . Positive_regulation CHUK TNF 10384145 624793 [IKK] activity in both RA and osteoarthritis FLS was strongly *induced* by and IL-1 in a concentration dependent manner . Positive_regulation CHUK TNF 10391945 626978 However , [IKK] activity was strongly *induced* by but not by IL-1beta . Positive_regulation CHUK TNF 10553091 565539 This study shows that the sesquiterpene lactone parthenolide inhibits a common step in NF-kappa B activation by preventing the *induced* [induction of I kappa B kinase (IKK)] and IKK beta , without affecting the activation of p38 and c-Jun N-terminal kinase . Positive_regulation CHUK TNF 10593965 572935 In summary , 5-ASA inhibits *stimulated* [IKKalpha] kinase activity toward IkappaBalpha in intestinal epithelial cells . Positive_regulation CHUK TNF 10744744 680750 MG-132 , a specific proteasome inhibitor , abrogated GA-induced degradation of RIP but failed to restore the *activation* of [IkappaB kinase] by , perhaps because , in the presence of GA and MG-132 , RIP accumulated in a detergent-insoluble subcellular fraction . Positive_regulation CHUK TNF 10753891 682362 Both and IL-1 rapidly *activate* the [IkappaB kinase (IKK)] complex , containing the catalytic subunits IKKalpha and IKKbeta , which directly phosphorylates IkappaB proteins . Positive_regulation CHUK TNF 10788610 688950 NAC also suppressed the *induced* activation of [IKKalpha] and IKKbeta , phosphorylation and degradation of IkappaB , and nuclear translocation of NF-kappaB . Positive_regulation CHUK TNF 10820281 694438 Auranofin also blocked [IKK] activation *induced* by and PMA/ionomycin , suggesting that the target of auranofin action is common among these diverse signal pathways . Positive_regulation CHUK TNF 10946303 722955 [IKK] activity was *stimulated* by both and TPA , and these effects were inhibited by staurosporine or herbimycin . Positive_regulation CHUK TNF 11096064 802167 OFF also inhibited *induced* IkappaBalpha degradation and TNF-alpha induced [IkappaB kinase (IKK)] activity in a shear stress dependent manner . Positive_regulation CHUK TNF 11096064 802169 Thus , OFF inhibits *induced* [IKK] activation , leading to a decrease in phosphorylation and degradation of inhibitory IkappaBalpha , which in turn results in the decrease of TNF-alpha induced NF-kappaB activation and potentially the transcription of target genes . Positive_regulation CHUK TNF 11133489 769147 *induced* activation of [I kappa B kinase] was also suppressed by ASA pretreatment . Positive_regulation CHUK TNF 11133741 769349 Consistent with that finding , stimulation with NiCl ( 2 ) or *activated* [IkappaB kinase-beta (IKKbeta)] , and transient transfection of dominant negative IKKbeta strongly inhibited NiCl ( 2 ) - and TNFalpha induced MCP-1 expression . Positive_regulation CHUK TNF 11179444 784697 [IKK] activity was *stimulated* by either or C2-ceramide , and these effects were inhibited by PD98059 or SB203580 . Positive_regulation CHUK TNF 11278695 811129 Vpu did not inhibit *mediated* activation of the [IkappaB kinase] but instead interfered with the subsequent TrCP dependent degradation of phosphorylated IkappaB-alpha . Positive_regulation CHUK TNF 11280761 798770 However , although *induced* rapid activation of [IkappaB kinase (IKK)] as expected , this activity was substantially reduced in the presence of VEGF . Positive_regulation CHUK TNF 11356844 834406 Activation of phosphatidylinositol (PI) 3-kinase/Akt signaling by *activates* [IKK] and NF-kappaB . Positive_regulation CHUK TNF 11359843 816423 *induces* activation of [inhibitor of NF-kappaB (IkappaB) kinase-beta] ( IKK-beta ) , a protein kinase that phosphorylates the NF-kappaB inhibitor IkappaB , and thereby targets the latter for degradation via the ubiquitin-proteasome pathway . Positive_regulation CHUK TNF 11359906 816585 The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2 dependent [IKK] recruitment to tumor necrosis factor (TNF) receptor 1 in *response* to . Positive_regulation CHUK TNF 11359906 816591 In *response* to the proinflammatory cytokine , [IKK] is activated after being recruited to the TNF receptor 1 (TNF-R1) complex via TNF receptor associated factor 2 (TRAF2) . Positive_regulation CHUK TNF 11359906 816597 Importantly , IKKgamma is not essential for *induced* [IKK] recruitment to TNF-R1 , as this occurs efficiently in IKKgamma-deficient cells . Positive_regulation CHUK TNF 11429546 831656 The molecular mechanism that underlies [IKK] activation in *response* to is still unknown . Positive_regulation CHUK TNF 11479295 860525 Since oxidants have been implicated in the regulation of NF-kappaB , the focus of the present study was the *activation* of [IKK] by in the presence or absence of hydrogen peroxide ( H ( 2 ) O ( 2 ) ) . Positive_regulation CHUK TNF 11479295 860543 In contrast , *induced* [IKK] activity rapidly and transiently resulting in IkappaBalpha degradation and NF-kappaB activation . Positive_regulation CHUK TNF 11479295 860546 Importantly , in the presence of H ( 2 ) O ( 2 ) , the ability of to *induce* [IKK] activity was markedly decreased and resulted in prevention of IkappaBalpha degradation and NF-kappaB activation . Positive_regulation CHUK TNF 11483407 844325 [IKK] activity was *stimulated* by both and TPA , and these effects were inhibited by Ro 31-8220 or tyrphostin 23 . Positive_regulation CHUK TNF 11689467 876280 Furthermore , LA dose-dependently inhibited *induced* [IkappaB kinase] activation , subsequent degradation of IkappaB , the cytoplasmic NF-kappaB inhibitor , and nuclear translocation of NF-kappaB . Positive_regulation CHUK TNF 11799112 922265 PTEN failed to block *induced* [IKK] activation , IkappaBalpha degradation , p105 processing , p65 ( RelA ) nuclear translocation , and DNA binding of NF-kappaB . Positive_regulation CHUK TNF 11855810 914050 There was no difference , however , in the ability of heat shock to inhibit mediated NF-kappaB activation , IkappaBalpha degradation , [IkappaB kinase] *activation* , and macrophage chemotactic protein-1 expression in the HSF-1-/- cells compared to the HSF-1+/+ cells . Positive_regulation CHUK TNF 11864612 917595 *induced* recruitment and activation of the [IKK complex] require Cdc37 and Hsp90 . Positive_regulation CHUK TNF 11864612 917623 Geldanamycin ( GA ) , an antitumor agent that disrupts the formation of this heterocomplex , prevents *induced* activation of [IKK] and NF-kappaB . Positive_regulation CHUK TNF 11954826 930700 Hyperoxia alone did not induce IkappaB kinase (IKK) activity , but significantly prolonged *mediated* activation of [IKK] activity . Positive_regulation CHUK TNF 11967992 938072 Binding of to its receptor *activates* [IKK complex] , which leads to inducement of NF-kappaB activity . Positive_regulation CHUK TNF 12023051 943492 stimulation *increased* [IKK] activity within 10 min , and then IKK activity decreased gradually within 30 min in HeLa cells . Positive_regulation CHUK TNF 12121873 965121 mediated [IKK] *activation* leads to IkappaBalpha and IkappaBbeta degradation . Positive_regulation CHUK TNF 12181188 977497 In conclusion , Fe2+ serves as a direct agonist to activate [IKK] , NF-kappaB , and TNF-alpha promoter activity and to *induce* the release of protein by cultured Kupffer cells in a redox status dependent manner . Positive_regulation CHUK TNF 12192055 980842 Substitution of two leucines within a C-terminal leucine zipper motif markedly reduced [IKK] *activation* by and IL-1 . Positive_regulation CHUK TNF 12192055 980848 Another point mutation resulting in a cysteine-to-serine substitution within the putative Zn finger motif affected [IKK] *activation* by but not by IL-1 . Positive_regulation CHUK TNF 12238566 989272 In addition , EGCG inhibited *mediated* activation of [IkappaB kinase] and subsequent activation of the IkappaB alpha/NF-kappaB pathway . Positive_regulation CHUK TNF 12692090 1093271 Only at high concentrations , cPG enhanced TNF-alpha induced cell death and inhibited induced [IkappaB-alpha kinase (IKK)] *activation* , IkappaB-alpha degradation , and NF-kappaB/p65 translocation , while promoting AP-1/c-jun phosphorylation . Positive_regulation CHUK TNF 12842894 1134792 induced [IKK] phosphorylation of NF-kappaB p65 on serine 536 is *mediated* through the TRAF2 , TRAF5 , and TAK1 signaling pathway . Positive_regulation CHUK TNF 12867425 1141844 A role for NF-kappaB essential modifier/IkappaB kinase-gamma ( NEMO/IKKgamma ) ubiquitination in the *activation* of the [IkappaB kinase complex] by . Positive_regulation CHUK TNF 12867425 1141851 Mutations of the zinc finger are found in patients with hypohidrotic ectodermal dysplasia with immunodeficiency ( HED-ID ) and lead to the impairment of *stimulated* [IKK] phosphorylation and activation . Positive_regulation CHUK TNF 12867425 1141857 Thus , the ubiquitination of NEMO mediated by c-IAP1 likely plays an important role in the *activation* of [IKK] by . Positive_regulation CHUK TNF 12934647 1132832 IL-1beta and can *induce* extracellular signal regulated kinase ( ERK ) , [IKK] , IkappaB degradation and NF-kappaB activation . Positive_regulation CHUK TNF 12939259 1157877 However , expression of the adaptor protein RIP , which is essential for [IKK] *activation* by , was decreased in cells exposed to H2O2 , and its chaperone Hsp90 was cleaved . Positive_regulation CHUK TNF 14764716 1207362 The *activation* of the [I-kappaB kinase (IKK)] complex by or LPS stimulates phosphorylation and degradation of I-kappaBalpha , leading to the nuclear translocation of NF-kappaB . Positive_regulation CHUK TNF 14764725 1207376 Antioxidant treatment of LPS stimulated neutrophils also inhibited the production of proinflammatory cytokines ( , macrophage inflammatory protein-2 , and IL-1beta ) , as well as *activation* of the kinases [IkappaB kinase alpha] , IkappaB kinase beta , p38 , Akt , and extracellular receptor activated kinases 1 and 2 . Positive_regulation CHUK TNF 15106733 1240538 plus IFN-gamma can *induce* extracellular signal regulated kinase ( ERK ) , [IKK] , IkappaB degradation and NF-kappaB activation . Positive_regulation CHUK TNF 15175328 1273485 The kinase activity of Rip1 is not required for *induced* [IkappaB kinase] or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2 . Positive_regulation CHUK TNF 15175328 1273487 *induced* [Ikk] and p38 MAP kinase activation is normal , and the Rip1D138N cells are resistant to TNF-alpha induced cell death , indicating that the kinase activity of Rip1 is not required to mediate its antiapoptotic functions . Positive_regulation CHUK TNF 15302572 1283879 induced *activation* of [IKK] was suppressed by HS in human bronchial epithelial cells , and this was associated with the absence of IKK in the immunoprecipitates . Positive_regulation CHUK TNF 15302572 1283882 Overexpression of NIK resumed *induced* activation of [IKK] in thermotolerant cells . Positive_regulation CHUK TNF 15310755 1303550 At the same time , the binding of AIP1 to TRAF2 inhibits *induced* [IKK-NF-kappaB] signaling . Positive_regulation CHUK TNF 15483420 1320514 In addition , theaflavin inhibited *mediated* activation of [IkappaB kinase] and subsequent activation of the IkappaB-alpha/nuclear factor-kappaB pathway . Positive_regulation CHUK TNF 15536134 1336411 In addition , we demonstrate that both [IkappaB kinase-alpha] and -beta are simultaneously recruited to the hes1 promoter in *response* to , coinciding with a maximum of IkappaBalpha release and gene activation . Positive_regulation CHUK TNF 15550384 1360972 Here we show that l-mimosine , a toxic non-protein amino acid that has been shown to reduce serum TNFalpha levels and affect inflammatory responses , specifically inhibits *induced* [IKK] but not JNK in a cell type-specific manner . Positive_regulation CHUK TNF 15710601 1395739 Evodiamine also inhibited *induced* Akt activation and its association with [IKK] . Positive_regulation CHUK TNF 16115877 1474130 Rip1 is required for [IkappaB kinase] activation in *response* to and has been implicated in the Toll-like receptor 3 (TLR3) response to double stranded RNA . Positive_regulation CHUK TNF 16115877 1474139 These studies suggest that Rip1 uses a similar , ubiquitin dependent mechanism to activate [IkappaB kinase-beta] in *response* to and TLR3 ligands . Positive_regulation CHUK TNF 16166517 1456569 Although *induced* [IKK] activity was rapidly attenuated by negative feedback , lipopolysaccharide (LPS) signaling and LPS-specific gene expression programs were dependent on a cytokine mediated positive feedback mechanism . Positive_regulation CHUK TNF 16246929 1471540 We found that both and LPS *activated* the [I-kappa B kinase complex (IKK)] in DPSCs to induce the phosphorylation and degradation of IkappaBalpha , resulting in the nuclear translocation of NF-kappaB . Positive_regulation CHUK TNF 16260783 1490022 Receptor interacting protein ( RIP ) plays a critical role in *induced* [IkappaB kinase (IKK)] activation and subsequent activation of transcription factor NF-kappaB . Positive_regulation CHUK TNF 16490171 1528584 NAC inhibited the phosphorylation of IKKbeta , [IKK alpha] , and IkappaB alpha *induced* by , but had no effect on the phosphorylation of IKKbeta , IKK alpha and IkappaB alpha induced by IL-1 . Positive_regulation CHUK TNF 16490171 1528603 NAC can inhibit the processes upstream of [IKK] activation *induced* by , which results in the decline of NF-kappaB activity . Positive_regulation CHUK TNF 16581780 1543848 Most importantly , NS5B protein in HCV subgenomic replicon cells interacted with endogenous IKKalpha , and then *mediated* [IKKalpha] kinase activation was significantly decreased by NS5B . Positive_regulation CHUK TNF 16603398 1550698 *Activation* of [IKK] by requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO . Positive_regulation CHUK TNF 16603398 1550705 Here , we present evidence that induces the polyubiquitination of RIP1 at Lys-377 and that this polyubiquitination is *required* for the activation of [IkappaB kinase (IKK)] and NF-kappaB . Positive_regulation CHUK TNF 16611882 1545334 Similarly , IKKgamma-delta mediates [IKK] kinase activity and downstream NF-kappaB dependent transcription in *response* to and the NF-kappaB inducing kinase-IKKalpha signaling pathway . Positive_regulation CHUK TNF 16636195 1562942 Metformin also dose-dependently inhibited *induced* NF-kappaB activation and TNF-alpha induced [IkappaB kinase] activity . Positive_regulation CHUK TNF 16723255 1570411 *induces* chromosomal abnormalities independent of ROS through [IKK] , JNK , p38 and caspase pathways . Positive_regulation CHUK TNF 16774932 1672080 The use of Ro-318220 and GO-6983 , general PKC inhibitors as well as MG-132 , a proteasome-specific inhibitor , abrogated PMA induced degradation of IKK-gamma and recovered the *activation* of [IKK] by , suggesting that IKK complex is predominantly degraded by the proteasome pathway in a PKC dependent manner . Positive_regulation CHUK TNF 16872805 1672440 Ad.IKKbeta+/- treatment completely inhibited *stimulated* [IKK] kinase activity , IkappaB alpha degradation and NFkappaB DNA binding in addition to completely blocking TNFalpha stimulated ICAM-1 and VCAM-1 expression . Positive_regulation CHUK TNF 16916935 1608531 Conversely , GRX1 knockdown sensitizes cells to oxidative inactivation of IKK-beta and dampens *induced* [IKK] and NF-kappaB activation . Positive_regulation CHUK TNF 17079781 1708982 Nox1 expression and activation inhibited *induced* [inhibitor of kappaB kinase (IKK)] , and NF-kappaB while promoting JNK activation and cell death . Positive_regulation CHUK TNF 17110449 1732118 Recent studies indicate that induced [IKK] *activation* requires activation of TAK1 , and we indeed found that celastrol inhibited the TAK1 induced NF-kappaB activation . Positive_regulation CHUK TNF 17158449 1694230 A green fluorescent protein fusion protein containing the last 100 residues of TAK1 ( TAK1-C100 ) abolished the interaction of endogenous TAB2/TAB3 with TAK1 , the phosphorylation of TAK1 , and prevented the activation of [IKK] and MAPK *induced* by IL-1 , , and RANKL . Positive_regulation CHUK TNF 17240450 1696454 Mechanistically , a non-radioactive IkappaB kinases (IKK) assay using immunoprecipitated IKKs protein demonstrated that magnolol inhibited both intrinsic and *stimulated* [IKK] activity , thus suggesting a critical role of magnolol in abrogating the phosphorylation and degradation of IkappaBalpha . Positive_regulation CHUK TNF 17244613 1710246 Our results therefore demonstrate that NEMO and IKKalpha can form a functional [IKK complex] that activates the classical NF-kappaB pathway in *response* to IL-1 but not . Positive_regulation CHUK TNF 17544371 1751870 Stable expression of TRIP or a RING mutant did not affect [IKK] activation *induced* by or IL-1 and had no affect on TNF induced apoptosis . Positive_regulation CHUK TNF 17690092 1800497 With moderate GSH depletion ( approximately 50 % ) , the down-regulation is IkappaB kinase (IKK) independent and likely acts on NF-kappaB transcriptional activity because *induced* [IKK] activation , IkappaBalpha phosphorylation and degradation , NF-kappaB nuclear translocation , NF-kappaB DNA binding in vitro , and NF-kappaB subunit RelA ( p65 ) recruitment to kappaB sites of target gene promoters all appear unaltered . Positive_regulation CHUK TNF 17764673 1807971 Piperine blocks the phosphorylation and degradation of IkappaBalpha by attenuating *induced* [IkappaB kinase] activity . Positive_regulation CHUK TNF 18560356 1965954 A significant fraction of *stimulated* [IkappaB kinase] activity in CaSki cells is Notch-1 dependent . Positive_regulation CHUK TNF 18597869 2059258 Metformin inhibits *induced* [IkappaB kinase] phosphorylation , IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K dependent AMPK phosphorylation . Positive_regulation CHUK TNF 18597869 2059280 Metformin had anti-inflammatory effects on endothelial cells and inhibited *induced* [IKKalpha/beta] phosphorylation , IkappaB-alpha degradation and IL-6 production in HUVEC . Positive_regulation CHUK TNF 18644347 1947738 however , Celecoxib had no effect on *induced* [IKK] activation and degradation of IkappaBalpha and IkappaBbeta , suggesting that it inhibited NF-kappaB activation via suppressing downstream of IKK activation and IkappaBs degradation . Positive_regulation CHUK TNF 18703532 2011801 Cilostazol also dose-dependently inhibited tumour necrosis factor alpha (TNFalpha) induced NF-kappaB activation and *induced* [I kappa B kinase] activity . Positive_regulation CHUK TNF 18957422 2001133 Expressing a constitutively active Plk1 in mammalian cells reduced *induced* [IKK] activation , resulting in decreased phosphorylation of endogenous IkappaBalpha and reduced NF-kappaB activation . Positive_regulation CHUK TNF 18957422 2001138 To activate endogenous Plk1 , cells were treated with nocodazole , which reduced *induced* [IKK] activation , and increased the phosphorylation of gammaBD . Positive_regulation CHUK TNF 18957422 2001141 Knocking down Plk1 in mammalian cells restored *induced* [IKK] activation in nocodazole treated cells . Positive_regulation CHUK TNF 18957422 2001150 Moreover , we identify Plk1 as a gammaBD kinase , which negatively regulates induced [IKK] *activation* and cyclin D1 expression , thereby affecting cell cycle regulation . Positive_regulation CHUK TNF 18981220 2015200 These results unveil a new , finely tuned mechanism for *induced* [IKK] activation modulated by TRAF2 phosphorylation and suggest that TRAF2 phosphorylation contributes to elevated levels of basal NF-kappaB activity in certain human cancers . Positive_regulation CHUK TNF 19010928 1991633 Therefore , inhibition of *induced* [IKK] activity with specific IKK inhibitor represents an attractive strategy to treat cancer patients . Positive_regulation CHUK TNF 19010928 1991642 This study reveals IKI-1 as a potent small molecule inhibitor of IKKalpha and IKKbeta , which effectively blocked mediated [IKK] *activation* and subsequent NF-kappaB activity . Positive_regulation CHUK TNF 19091594 2031050 Compared to those observed in wild-type MEFs , induced [IkappaB kinase (IKK)] *activation* and IkappaBalpha degradation were enhanced in TRAF6-deficient MEFs . Positive_regulation CHUK TNF 19091594 2031054 Moreover , the reintroduction of exogenous TRAF6 into TRAF6-deficient MEFs clearly suppressed *induced* [IKK] activation , NF-kappaB activation and subsequent cytokine expression . Positive_regulation CHUK TNF 19091594 2031059 In contrast , both the deletion mutant ( DeltaN ) and the point mutant ( C70A ) of TRAF6 , which is defective in its ubiquitin ligase activity , failed to repress *induced* [IKK] activation , NF-kappaB activation and cytokine production . Positive_regulation CHUK TNF 19181934 2043861 Inhibition of ERK 1/2 MAPK with PD98059 attenuated the protective role of IL-10 against *induced* activation of [IKK] and NF kappaB as well as cardiomyocyte apoptosis . Positive_regulation CHUK TNF 19336568 2056503 Tumor necrosis factor (TNF) receptor associated factor 2 ( TRAF2 ) is an adaptor protein that modulates the activation of the c-Jun NH ( 2 ) terminal kinase ( JNK ) /c-Jun and [IkappaB kinase (IKK)/nuclear] factor-kappaB (NF-kappaB) signaling cascades in *response* to stimulation . Positive_regulation CHUK TNF 19336568 2056509 Although many serine/threonine kinases have been implicated in *induced* [IKK] activation and NF-kappaB dependent gene expression , most of them do not directly activate IKK . Positive_regulation CHUK TNF 19336568 2056514 These results reveal a new level of complexity in *induced* [IKK] activation modulated by TRAF2 phosphorylation and suggest that TRAF2 phosphorylation is one of the events that are responsible for elevated basal NF-kappaB activity in certain human cancers . Positive_regulation CHUK TNF 19409903 2082509 TRAF2 suppresses basal IKK activity in resting cells and can *activate* [IKK] in TRAF2 and TRAF5 double knockout cells . Positive_regulation CHUK TNF 19409903 2082516 Although TNFalpha induced receptor interacting protein 1 ubiquitination is indeed impaired in T2/5 DKO cells , stimulation further *increases* [IKK] activity in these cells , resulting in significantly elevated expression of NF-kappaB target genes to a level higher than that in wild-type cells . Positive_regulation CHUK TNF 19409903 2082519 Inhibition of NIK in T2/5 DKO cells attenuates basal IKK activity and restores robust *induced* [IKK] activation to a level comparable with that seen in wild-type cells . Positive_regulation CHUK TNF 19409903 2082522 This suggests that can *activate* [IKK] in the absence of TRAF2 and TRAF5 expression and receptor interacting protein 1 ubiquitination . Positive_regulation CHUK TNF 19559609 2104133 Consistent with these results , peperomin E and 2,6-didehydropeperomin B blocked the *induced* activation of [IkappaB kinase] , while they had no direct effect on the IkappaB kinase activity . Positive_regulation CHUK TNF 19591457 2122800 TPCK inhibited induced [IKK] *activation* and directly blocked IKK activity in vitro . Positive_regulation CHUK TNF 19592502 2137139 Whereas licochalcone A had no effect on the recruitment of receptor interacting protein 1 and IkappaB kinase beta (IKKbeta) to TNF receptor I by TNF-alpha , it significantly inhibited *induced* [IkappaB kinase complex (IKK)] activation and inhibitor of nuclear factor-kappaB degradation . Positive_regulation CHUK TNF 19592502 2137140 In contrast , a structurally related compound , echinatin , failed to inhibit *induced* [IKK] activation and NF-kappaB activation , suggesting that the 1,1-dimethy-2-propenyl group in licochalcone A is important for the inhibition of NF-kappaB . Positive_regulation CHUK TNF 19854138 2155746 A ubiquitin replacement strategy in human cells reveals distinct mechanisms of [IKK] *activation* by and IL-1beta . Positive_regulation CHUK TNF 19854138 2155753 We demonstrate that K63 of ubiquitin and the catalytic activity of Ubc13 , an E2 that catalyzes K63 polyubiquitination , are required for [IKK] *activation* by IL-1beta , but surprisingly , not by . Positive_regulation CHUK TNF 19854138 2155768 We further show that [IKK] *activation* by requires Ubc5 , which functions with the E3 cIAP1 to catalyze polyubiquitination of RIP1 not restricted to K63 of ubiquitin . Positive_regulation CHUK TNF 19877072 2160720 In sharp contrast , DEX did not affect *induced* [IKK] phosphorylation , IkappaBalpha degradation , p65 nuclear translocation , or MAPK activation in RA FLS . Positive_regulation CHUK TNF 20064526 2205519 The TRAF2 RING domain mediated polyubiquitination of RIP1 is believed to be essential for TNFalpha induced IKK activation , and the RING-domain deleted TRAF2 ( TRAF2-DeltaR ) has been widely used as a dominant negative in transient overexpression systems to block induced JNK and [IKK] *activation* . Positive_regulation CHUK TNF 20064526 2205522 Here , we report that stable expression of TRAF2-DeltaR at a physiological level in TRAF2 and TRAF5 double knockout ( TRAF2/5 DKO ) cells almost completely restores normal *induced* [IKK] activation , but not RIP1 polyubiquitination . Positive_regulation CHUK TNF 20064526 2205528 ( ii ) RIP1 polyubiquitination is not essential for *induced* [IKK activation; and (iii)] prolonged JNK activation has no obligate role in TNFalpha induced cell death . Positive_regulation CHUK TNF 20082310 2212587 Stimulation of myoblasts with *activated* [IkappaB kinase alpha/beta] ( IKKalpha/beta ) , IkappaBalpha phosphorylation , p65 phosphorylation , and kappaB-luciferase activity . Positive_regulation CHUK TNF 20153843 2236126 Whereas Licochalcone A potently inhibited *induced* [IKK] activation , IkappaBalpha degradation , nuclear localization of NF-kappaB and its DNA binding activity , no inhibitory effect was observed by reduced Licochalcone A . Positive_regulation CHUK TNF 20484576 2288707 We describe a new regulatory mechanism for PLK1 : PLK1 negatively regulates *induced* [IKK] activation by inhibiting the ubiquitination of NEMO . Positive_regulation CHUK TNF 20724805 2306881 The results showed that ruscogenin significantly suppressed p65 phosphorylation , IkappaB-alpha phosphorylation and degradation , and inhibited [IkappaB kinase alpha (IKKalpha)] and IKKbeta activation *induced* by . Positive_regulation CHUK TNF 21138840 2384294 Conversely , overexpression of spliced XBP1 attenuated *induced* phosphorylation of [IKK] , I?Ba , and NF-?B p65 , accompanied by decreased NF-?B activity and reduced adhesion molecule expression . Positive_regulation CHUK TNF 21232017 2397647 In fact , it seems that most , if not all , proteins relevant for this process have been identified and extensive biochemical and genetic data are available for the role of these factors in induced [IKK] *activation* . Positive_regulation CHUK TNF 21924245 2501746 For inhibition of *induced* [IKK] activation , DBA was most active . Positive_regulation CHUK TNF 22231395 2544702 Western blotting was used to assess the expression of both NF-?B regulated gene products and induced *activation* of p65 , I?Ba , and [IKK] . Positive_regulation CHUK TNF 22231395 2544706 In addition to inhibition of NF-?B p65 nuclear translocation , the compound also suppressed *induced* phosphorylation of p65 and [IKK] , and the degradation of I?Ba . Positive_regulation CHUK TNF 23125156 2729383 Pretreatment with GG-52 suppressed induced *activation* of I?B kinase ( [IKK] ) and NF-?B signaling in MKN-45 cells . Positive_regulation CHUK TNF 23266860 2741454 Inhibition of protein kinase C ( PKC ) -a activity by Go6976 and PKC-a siRNA prevented *induced* [IKK] activity , I?B-a phosphorylation/degradation and NF-?B activation . Positive_regulation CHUK TNF 23530055 2777444 [IKK] can be *activated* by growth factor stimulation or alpha engagement . Positive_regulation CHUK TNF 23935096 2840749 Additionally , we find that SK1 is not required for *induced* [IKK] phosphorylation , I?B degradation , nuclear translocation of NF-?B subunits , and transcriptional NF-?B activity . Positive_regulation CHUK TNF 24345501 2880883 *stimulated* significantly phosphorylation on Ser536 of NF-?B/p65 , Ser473 of Akt at 5-15 min , and activations of [IKK-ß] and ERK at 15-30 min. Diosgenin ( 1 µmol · Positive_regulation CHUK TNF 9710600 526817 Our studies now demonstrate that HTLV-1 Tax activates the recently identified cellular kinases [IkappaB kinase alpha (IKKalpha)] and IKKbeta , which normally phosphorylate IkappaB alpha on both of its N-terminal regulatory serines in *response* to and interleukin-1 (IL-1) stimulation . Positive_regulation CHUK TNFSF10 10958661 724874 In this report , we demonstrated that the death domain kinase RIP is essential for *induced* [IkappaB kinase (IKK)] and JNK activation . Positive_regulation CHUK TNFSF10 10958661 724875 We found that ectopic expression of the dominant negative mutant RIP , RIP ( 559-671 ) , blocks *induced* [IKK] and JNK activation . Positive_regulation CHUK TNFSF10 10958661 724878 In addition , we also demonstrated that the TNF receptor associated factor 2 (TRAF2) plays little role in induced [IKK] *activation* although it is required for TRAIL mediated JNK activation . Positive_regulation CHUK TNFSF10 10958661 724887 These results indicated that the death domain kinase RIP , a key factor in TNF signaling , also plays a pivotal role in *induced* [IKK] and JNK activation . Positive_regulation CHUK TNFSF10 19372584 2058980 PRMT5 contributed to *induced* activation of [inhibitor of kappaB kinase (IKK)] and nuclear factor-kappaB (NF-kappaB) , leading to induction of several NF-kappaB target genes . Positive_regulation CHUK TNFSF10 22932446 2706168 On the other hand , kurarinone significantly inhibited *induced* [IKK] activation , I?B degradation and nuclear translocation of NF-?B , as well as effectively suppressed cellular FLICE-inhibitory protein long form ( cFLIPL ) expression . Positive_regulation CIB1 CCND1 10377442 623832 Silibinin induced G1 arrest was associated with a marked decrease in the kinase activity of cyclin dependent kinases (CDKs) and associated cyclins because of a highly significant decrease in , CDK4 , and CDK6 levels and an *induction* of Cip1/p21 and [Kip1/p27] followed by their increased binding with CDK2 . Positive_regulation CIB1 CCND1 18180298 1875805 Additionally , whereas *stabilized* p27 [KIP1] and inhibited RhoA induced ROCK kinase activity , promoting cellular migration , cyclin D1b failed to stabilize p27 KIP1 or inhibit ROCK kinase activity and had no effect on migration . Positive_regulation CIB1 CCND1 21312237 2398654 WIN 55,212-2 also upregulated phospho-ERK1/2 , *induced* [Kip1/p27] and Cip1/WAF1/p21 expression , decreased and cyclin E expression , decreased Cdk 2 , Cdk 4 , and Cdk 6 expression levels , and decreased phospho-Rb and E2F-1 expression . Positive_regulation CIB1 CCND1 22771367 2676455 We found that TS extracts ( 10-75 µg/mL ) arrested HL-60 cells at the G1-S transition phase through the reductions of , CDK4 , Cyclin E , CDK2 , and Cyclin A , and *induction* of CDK inhibitor [p27KIP] levels . Positive_regulation CIB1 EPHB2 19492998 2091373 The NFkB dependent drop in cyclin D1 , along with the *dependent* induction of p21 [Cip1/Kip1] , is responsible for growth arrest . Positive_regulation CIB1 FOXO1 15087469 1258118 These studies demonstrate for the first time that can *regulate* [p27kip] nuclear localization . Positive_regulation CIB1 FOXO1 16631585 1552477 *regulates* transcription of [cki-1/Cip/Kip] and repression of lin-4 during C. elegans L1 arrest . Positive_regulation CIB1 FOXO1 17015685 1629786 Consistent with the important *role* of in p27 [kip1] transcription , stimulated Vav1 ( -/- ) T cells failed to down-regulate the expression of p27 kip1 , explaining their G0-G1 arrest . Positive_regulation CIB1 FOXO1 19281796 2055704 PARP-1 represses *mediated* expression of cell cycle inhibitor p27 ( [Kip1] ) gene . Positive_regulation CIB1 TNF 21075101 2371461 *regulates* p27 [kip] expression and apoptosis in smooth muscle cells of human carotid plaques via forkhead transcription factor O1 . Positive_regulation CIC FOXA1 19445897 2090623 We have also demonstrated that overexpression and silencing of increases and *reduces* [CIC] transcript and protein levels , respectively . Positive_regulation CIDEA FAS 22278400 2617441 Importantly , we observed that [Cidea] expression in hepatocytes was specifically *induced* by saturated , and such induction was reduced when sterol response element binding protein ( SREBP)1c was knocked down . Positive_regulation CIDEA FOXO1 21945815 2522064 Finally , suppression of *inhibited* palmitic acid induced [Cidea] upregulation and apoptosis . Positive_regulation CIITA EPHB2 16785500 1576989 and p38 MAPK signaling pathways negatively *regulate* [CIITA] gene expression in dendritic cells and macrophages . Positive_regulation CIITA EPHB2 16785500 1577083 In macrophages , LPS inhibited IFN-gamma-inducible CIITA and MHC class II expression without affecting expression of IFN regulatory factor-1 and MHC class I. Blocking and p38 by MAPK inhibitors not only rescued LPS mediated inhibition , but also *augmented* IFN-gamma induction of [CIITA] . Positive_regulation CIITA TNF 10202014 605904 Our results demonstrate that does not *enhance* IFN-gamma induced transcriptional activation of the type IV [CIITA] promoter , indicating that the enhancing effect of TNF-alpha is mediated downstream of CIITA transcription . Positive_regulation CIITA TNF 11675374 873201 Increased binding of IFN regulating factor 1 mediates the synergistic *induction* of [CIITA] by IFN-gamma and in human thyroid carcinoma cells . Positive_regulation CIITA TNF 11675374 873207 The aim of this study was to find whether [CIITA] is synergistically *induced* by IFN-gamma and in the human thyroid MRO-87-1 cell line , and to investigate the molecular mechanisms responsible for this synergism . Positive_regulation CIITA TNF 11675374 873211 We have demonstrated that IFN-gamma and synergistically *induce* HLA-DRalpha and [CIITA] mRNAs , but prolonged incubation resulted in the inhibition of CIITA mRNA accumulation . Positive_regulation CIITA TNF 11914744 925329 IFN gamma and synergistically *induced* MHC class II expression on insulinoma cells through the induction of [CIITA] ; Positive_regulation CISH ABCA4 23144455 2710778 The results suggest a possible *role* of and , in particular , the NBD1 domain in [11-cis-retinal] binding . Positive_regulation CISH EPHB2 18922468 1977195 Autophosphorylation occurs in [cis] , does not *involve* activation , and is essential to ensure the correct folding and stability of the protein . Positive_regulation CISH EPHB2 9832563 551918 [Cis-platinum] , which activated SAPK2 but *induced* little activity , also induced membrane blebbing that was dependent on the expression of HSP27 . Positive_regulation CISH IFI27 10738115 679643 Interestingly , [9-cis-RA] *induced* transiently the expression of p21 ( Waf1/Cip1 ) , ( Kip1 ) , p300 , CBP , BAX , Bak and bcl-2 proteins , respectively . Positive_regulation CISH IL1B 10969179 728338 In tonsillar cells , [CIS] expression was increased and SOCS-2 was *induced* by , IL-6 , PRL and GH . Positive_regulation CISH IL1B 11014223 736328 Although and TNFalpha alone *induced* only weakly the expression of SOCS-3 and [CIS] , these cytokines strongly potentiated the induction of these two SOCS by GH . Positive_regulation CISH IL1B 11014223 736334 Considering the ability of these SOCS to inhibit the JAK-STAT pathway induced by GH , these results suggest that the overexpression of SOCS-3 and [CIS] mRNAs *induced* by and TNFalpha or by endotoxin in vivo may play a role in the GH resistance induced by sepsis . Positive_regulation CISH MAP2K6 11727828 884572 We analyzed the *role* of for IL-6 signal transduction and transcriptional activation of the [suppressor of cytokine signaling (SOCS)] 3 promoter . Positive_regulation CISH MAP2K6 18922468 1977201 Autophosphorylation occurs in [cis] , does not *involve* activation , and is essential to ensure the correct folding and stability of the protein . Positive_regulation CISH RARB 9751509 533606 Similar to ATRA , [9-cis-RA] transiently *induced* the messenger RNA expression of the nuclear RA receptor , suggesting a role for this receptor in the effects of retinoids on the differentiation and proliferation of A spermatogonia . Positive_regulation CISH TLR7 15491991 1347437 However , *induction* of [SOCS] proteins by ligands was independent of type I interferon . Positive_regulation CISH TNF 11014223 736327 Although IL-1/beta and alone *induced* only weakly the expression of SOCS-3 and [CIS] , these cytokines strongly potentiated the induction of these two SOCS by GH . Positive_regulation CISH TNF 11014223 736333 Considering the ability of these SOCS to inhibit the JAK-STAT pathway induced by GH , these results suggest that the overexpression of SOCS-3 and [CIS] mRNAs *induced* by IL-1beta and or by endotoxin in vivo may play a role in the GH resistance induced by sepsis . Positive_regulation CISH TNF 15072573 1232600 Recently , it was demonstrated that *induction* of [suppressor of cytokine signaling (SOCS)-3] by and GH is an important mechanism by which these cytokines impair insulin sensitivity . Positive_regulation CISH TNF 8132224 251470 Thus [cis-UCA] does not *act* through induction or by influencing DC migration , and other studies indicate that histamine-like receptors in the skin may be involved . Positive_regulation CKAP4 TP63 19783996 2147687 Such modifications affect [p63] stability and *induce* a dependent activation of proapoptotic promoters . Positive_regulation CKAP4 TP63 21820419 2490436 Therefore , we propose a potential biological *role* of interaction in regulation of [p63] during epidermal differentiation . Positive_regulation CKAP5 STK39 18083840 1837197 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation CKM LIPG 9925374 559368 Moreover , the [M-CK] mRNA level was greatly *increased* in soleus , with no change in . Positive_regulation CKS1B CCND1 16924241 1692236 Mutant B-RAF signaling and *regulate* [Cks1/S-phase] kinase associated protein 2-mediated degradation of p27Kip1 in human melanoma cells . Positive_regulation CKS1B CCND1 16924241 1692253 Importantly , expression of [Cks1] is *regulated* by B-RAF and at the mRNA level . Positive_regulation CLASP1 STK39 18083840 1837002 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation CLASP2 STK39 18083840 1836987 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation CLCA1 MUC16 12568493 1029471 We show here that [hCLCA1] expression in NCI-H292 cells specifically *induces* soluble gel forming production . Positive_regulation CLCA1 TNF 15696080 1372039 significantly *increased* MUC5AC and hCLCA1 mRNA as well as mucus and [hCLCA1] protein expression in the mucosal explant tissue ( P < .05 ) . Positive_regulation CLCN3 CCND1 23270726 2737496 The results indicated that enhanced expression increased the activation of volume activated chloride currents and *promoted* the expression of [ClC-3] chloride channel proteins . Positive_regulation CLDN1 EPHB2 23766441 2915874 An upregulated [claudin-1] expression *induces* MMP-9 and signalling to activate Notch signalling , which in turn inhibits the goblet cell differentiation . Positive_regulation CLDN1 MAP2K6 10833473 697769 Functional was *required* for the expression and membrane association of claudin-2 but not [claudin-1] in T84 cells . Positive_regulation CLDN1 TNF 18949385 1978884 [Claudin-1] expression is *induced* by in human pancreatic cancer cells . Positive_regulation CLDN1 TNF 18949385 1978885 Expression of [claudin-1] was *up-regulated* by in a concentration dependent manner in PANC-1 cells . Positive_regulation CLDN1 TNF 21624620 2436789 [Claudin-1] *upregulation* by IL-1ß or was suppressed by dexamethasone but not by rapamycin , FK506 , or salbutamol . Positive_regulation CLDN10 EGF 14593119 1200114 Accompanying these *induced* changes in [claudin] expression was a 3-fold increase in transepithelial resistance , a functional measure of TJs . Positive_regulation CLDN10 EGFR 14593119 1200065 activation differentially *regulates* [claudin] expression and enhances transepithelial resistance in Madin-Darby canine kidney cells . Positive_regulation CLDN10 EGFR 17855771 1818158 Juxtacrine activation of *regulates* [claudin] expression and increases transepithelial resistance . Positive_regulation CLDN10 IFNG 17582238 1768015 lipopolysaccharide , and tumour necrosis factor-alpha *had* no effect on [claudin] protein expression or distribution . Positive_regulation CLDN10 MST1R 18204077 1876472 Activation of differentially *regulates* [claudin] expression and localization : role of claudin-1 in RON mediated epithelial cell motility . Positive_regulation CLDN10 MST1R 18204077 1876542 We report here that activation of differentially *regulates* tight junction function and [claudin] expression . Positive_regulation CLDN10 MST1R 18204077 1876590 In conclusion , activation differentially *regulates* [claudin] expression in epithelial cells . Positive_regulation CLDN10 PAEP 23813140 2808203 Our aim was to investigate if plus RBV *regulate* [claudin] expression . Positive_regulation CLDN16 EPHB2 19914201 2209896 These results suggest that the *dependent* phosphorylation of [claudin-16] affects the tight junctional localization and function of claudin-16 . Positive_regulation CLDN16 MAP2K6 19914201 2209902 These results suggest that the *dependent* phosphorylation of [claudin-16] affects the tight junctional localization and function of claudin-16 . Positive_regulation CLDN2 IL1B 15350541 1292415 *regulates* expression of Cx32 , occludin , and [claudin-2] of rat hepatocytes via distinct signal transduction pathways . Positive_regulation CLDN2 MAP2K6 10833473 697776 Functional was *required* for the expression and membrane association of [claudin-2] but not claudin-1 in T84 cells . Positive_regulation CLDN2 TNF 19214581 2105881 Our aim has been to characterize the molecular mechanisms regulating the expression of the channel forming tight-junctional protein [claudin-2] in *response* to the pro-inflammatory cytokine , which is elevated , for example , in active Crohn 's disease . Positive_regulation CLDN2 TNF 19214581 2105883 The [claudin-2] protein level was *increased* by without changes in subcellular tight-junctional protein localization as revealed by confocal laser scanning microscopy . Positive_regulation CLDN2 TNF 19214581 2105884 Thus , the *up-regulation* of [claudin-2] by is attributable to the regulation of the expression of the gene , as a result of which epithelial barrier function is disturbed , for example , during chronic intestinal inflammation . Positive_regulation CLDN4 EPHB2 20861219 2337096 Further experiments indicated that p44/42 is not *involved* in the transcriptional regulation of [claudin-4] . Positive_regulation CLDN4 MAP2K6 19409881 2082505 The exogenous expression of constitutively activated *increased* [claudin-4] expression . Positive_regulation CLDN5 PLAT 21610723 2470314 Both and age independently *increased* [claudin 5] and occludin phosphorylation during ischemia . Positive_regulation CLEC11A TNF 16720733 1575885 The aim of this study was to determine whether IL-10 inhibits GM-CSF- and *induced* [p47] ( PHOX ) phosphorylation and to investigate the molecular mechanisms involved in this effect . Positive_regulation CLEC1B TMEM100 22293702 2546004 Furthermore , podoplanin , another in lymphatic vessels is *required* for their separation from veins by activating [CLEC2] , the specific ligand in platelets , leading to thrombus formation between veins and lymphatic vessels . Positive_regulation CLEC1B TMEM156 22293702 2546022 Furthermore , podoplanin , another in lymphatic vessels is *required* for their separation from veins by activating [CLEC2] , the specific ligand in platelets , leading to thrombus formation between veins and lymphatic vessels . Positive_regulation CLEC1B TMEM211 22293702 2546102 Furthermore , podoplanin , another in lymphatic vessels is *required* for their separation from veins by activating [CLEC2] , the specific ligand in platelets , leading to thrombus formation between veins and lymphatic vessels . Positive_regulation CLEC1B TMEM213 22293702 2546039 Furthermore , podoplanin , another in lymphatic vessels is *required* for their separation from veins by activating [CLEC2] , the specific ligand in platelets , leading to thrombus formation between veins and lymphatic vessels . Positive_regulation CLEC5A TNF 22005300 2503239 Triggering [MDL-1] on these cells *induced* production of NO and , which were found to be elevated in the serum of treated mice and required for MDL-1 induced shock . Positive_regulation CLEC7A IL1B 19222370 2054428 The transcription of was *induced* through mannose receptor ( MR ) , Toll-like receptor (TLR) 2 , and [dectin-1] but not through TLR4 and TLR9 . Positive_regulation CLEC7A TNF 19273561 2063323 The upregulation of and downregulation of IL-12p70 *required* [Dectin-1] , but not IL-10 . Positive_regulation CLEC7A TNF 19410299 2128206 Zymosan *enhanced* [dectin-1/TLR2/TLR4] expression and TNF-alpha/IL-10 production in all of three types of cell , whereas p-beta-glucan increased dectin-1/TLR4 and production in AMs but inhibited IL-10 in mDCs . Positive_regulation CLIC4 TNF 20504765 2289240 Moreover , alpha *induced* nuclear translocation of [CLIC4] is dependent on nitric-oxide synthase activity . Positive_regulation CLIP1 STK39 18083840 1836927 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation CLIP1 TLR7 20631258 2321956 mediated B cell activation *results* in ectopic [CLIP] expression that promotes B cell dependent inflammation . Positive_regulation CLIP2 TLR7 20631258 2321976 mediated B cell activation *results* in ectopic [CLIP] expression that promotes B cell dependent inflammation . Positive_regulation CLIP3 TLR7 20631258 2321966 mediated B cell activation *results* in ectopic [CLIP] expression that promotes B cell dependent inflammation . Positive_regulation CLIP4 TLR7 20631258 2321986 mediated B cell activation *results* in ectopic [CLIP] expression that promotes B cell dependent inflammation . Positive_regulation CLN3 EPHB2 22465903 2612940 [C9,t11,t13-CLN] is less adipogenic for 3T3-L1 cells than LN and this is partly *due* to its apoptotic effect on proliferating preadipocytes and to the sustained phosphorylation seen during mitotic clonal expansion . Positive_regulation CLN5 EPHB2 22465903 2612941 [C9,t11,t13-CLN] is less adipogenic for 3T3-L1 cells than LN and this is partly *due* to its apoptotic effect on proliferating preadipocytes and to the sustained phosphorylation seen during mitotic clonal expansion . Positive_regulation CLN6 EPHB2 22465903 2612942 [C9,t11,t13-CLN] is less adipogenic for 3T3-L1 cells than LN and this is partly *due* to its apoptotic effect on proliferating preadipocytes and to the sustained phosphorylation seen during mitotic clonal expansion . Positive_regulation CLN8 EPHB2 22465903 2612943 [C9,t11,t13-CLN] is less adipogenic for 3T3-L1 cells than LN and this is partly *due* to its apoptotic effect on proliferating preadipocytes and to the sustained phosphorylation seen during mitotic clonal expansion . Positive_regulation CLN9 EPHB2 22465903 2612944 [C9,t11,t13-CLN] is less adipogenic for 3T3-L1 cells than LN and this is partly *due* to its apoptotic effect on proliferating preadipocytes and to the sustained phosphorylation seen during mitotic clonal expansion . Positive_regulation CLTA TNF 20564232 2290299 Immunoprecipitation studies revealed associations of NM IIB with [clathrin] , FADD , and caspase 8 in *response* to suggesting a role for NM IIB in TNFR1 endocytosis and the formation of the death inducing signaling complex (DISC) . Positive_regulation CLTC TNF 20564232 2290300 Immunoprecipitation studies revealed associations of NM IIB with [clathrin] , FADD , and caspase 8 in *response* to suggesting a role for NM IIB in TNFR1 endocytosis and the formation of the death inducing signaling complex (DISC) . Positive_regulation CLU APOE 15519757 1328971 Both IL-1 beta and TNFalpha treatments *increased* [ApoJ] secretion from adult glia , with little effect on . Positive_regulation CLU ATP5O 18256250 1865592 The persistent increase in [Cl(i)] *required* intact alpha2/alpha3 activity , indicating that trains of action potentials reset the thermodynamic equilibrium for NKCC1 transport by lowering Na ( i ) . Positive_regulation CLU CEBPB 10634518 576723 C/EBP-delta mRNA levels are low in nonsealed glands , but are rapidly and transiently induced in sealed glands by 24 h . mRNA expression is also relatively low in nonsealed glands , but is induced in sealed glands within 72 h. Expression of the apoptosis associated mRNAs encoding bax and [TRPM-2] is also *induced* in sealed glands by 24-48 h. Apoptosis and a moderate degree of tissue remodeling occur within the sealed glands in spite of systemic hormone levels capable of sustaining lactation . Positive_regulation CLU CEBPD 10634518 576724 mRNA levels are low in nonsealed glands , but are rapidly and transiently induced in sealed glands by 24 h . C/EBP-beta mRNA expression is also relatively low in nonsealed glands , but is induced in sealed glands within 72 h. Expression of the apoptosis associated mRNAs encoding bax and [TRPM-2] is also *induced* in sealed glands by 24-48 h. Apoptosis and a moderate degree of tissue remodeling occur within the sealed glands in spite of systemic hormone levels capable of sustaining lactation . Positive_regulation CLU CEBPD 16192306 1468321 In HC11 cells , alone is *sufficient* to induce IGFBP5 and [SGP2] . Positive_regulation CLU CFTR 15517342 1367222 Activation of by isobutyl-1-methylxanthine ( IBMX , 100 microM ) and forskolin ( 2 microM ) *increased* [ [Cl-]i] by 9.6+/-1.5 mM ( n=35 ) . Positive_regulation CLU CXCR4 20813109 2341755 [Clusterin] *induces* expression and migration of cardiac progenitor cells . Positive_regulation CLU DES 8170836 255213 *induced* [TRPM-2] expression over a longer duration than did castration , suggesting that more than just the decrease of serum testosterone to castrate levels plays a role in the expression of TRPM-2 . Positive_regulation CLU EGF 10215617 608149 Nerve growth factor and *stimulate* [clusterin] gene expression in PC12 cells . Positive_regulation CLU EGFR 19218870 2039564 These results suggest that [clusterin] *requires* activation to deliver its mitogenic signal through the Ras/Raf-1/MEK/ERK signaling cascade in astrocytes . Positive_regulation CLU EGR1 15689620 1388506 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Positive_regulation CLU F11 24126506 2853259 Various studies have evaluated the *role* of in DF and [CLI] that resulted favourable in terms of feasibility , technical efficacy , the reduced number of complications , and limb salvage rates . Positive_regulation CLU F2R 9189857 437510 The protein kinase C inhibitor RO-32-0432 ( 1 microM ) inhibited the thrombin induced increase in clusterin mRNA , suggesting that activation may *regulate* renal [clusterin] mRNA levels through protein kinase C . Positive_regulation CLU FOS 10406964 629678 Here , we demonstrate , by supershift analysis , that JunB , JunD , Fra1 , Fra2 , and c-Fos bound to AP-1 but that prior treatment of the cells with TGFbeta reduced dramatically c-Fos binding , suggesting that might be playing a negative regulatory *role* in [clusterin] gene expression . Positive_regulation CLU FOXL2 23051594 2702787 We show that human gonadotroph cell pituitary tumors , unlike other secreting tumor types , express high levels of gonadotroph-specific forkhead transcription factor FOXL2 , and both PTTG and *stimulate* gonadotroph [clusterin (Clu)] expression . Positive_regulation CLU FOXL2 23051594 2702790 directly *stimulates* the [Clu] gene promoter , and we show that PTTG triggers ataxia telangiectasia mutated kinase/IGF-I/p38MAPK DNA damage/chromosomal instability signaling , which in turn also induces Clu expression . Positive_regulation CLU GAST 21995960 2526103 *upregulates* the prosurvival factor secretory [clusterin] in adenocarcinoma cells and in oxyntic mucosa of hypergastrinemic rats . Positive_regulation CLU GAST 21995960 2526104 We show that the gastric hormone *induces* the expression of the prosurvival secretory [clusterin] ( sCLU ) in rat adenocarcinoma cells . Positive_regulation CLU GAST 21995960 2526128 Luciferase reporter assay indicates that the AP-1 transcription factor complex is involved in *mediated* activation of the [clusterin] promoter . Positive_regulation CLU GAST 21995960 2526142 *induced* [clusterin] expression and subsequent secretion is dependent on sustained treatment , because removal of gastrin after 1-2 h abolished the response . Positive_regulation CLU GDNF 15212950 1262425 Laminin , Mpl3 , Alcam , Bin1 , Id1 , Id2 , Id3 , neuregulin1 , the ephrinB2-receptor , neuritin , focal adhesion kinase ( FAK ) , Tc10 , Pdpk1 , [clusterin] , GTP-cyclooxygenase1 , and follistatin are genes *up-regulated* by overexpression . Positive_regulation CLU GFAP 11150487 780520 [Clusterin] is sensitive marker of glial reactivity in AIDS brains and its enhanced expression was not *dependent* on increases in . Positive_regulation CLU GPR39 22545109 2590373 activation however , *increased* the expression of the anti-apoptotic protein [clusterin] in butyrate treated cells . Positive_regulation CLU HIF1A 16414399 1514461 However , little is known about the endogenous angiogenic response and the *role* of in human [critical limb ischemia (CLI)] . Positive_regulation CLU HSF1 19353783 2058027 We report that proteasome inhibition promotes both *dependent* [CLU] gene expression induction and protein accumulation due to reduced degradation . Positive_regulation CLU HSPA5 22689054 2763387 *regulates* [clusterin] stability , retrotranslocation and mitochondrial localization under ER stress in prostate cancer . Positive_regulation CLU IGF1 21460853 2469811 ATM dependent induction *regulates* secretory [clusterin] expression after DNA damage and in genetic instability . Positive_regulation CLU IGF1R 15689620 1388507 Delayed activation of signaling *regulates* [clusterin] expression , a pro-survival factor . Positive_regulation CLU IL1B 18240213 1871412 and TNFalpha *caused* increased release of chitinase 3-like protein 1 (CHI3L1) , CHI3L2 , complement factor B , matrix metalloproteinase 3 , ECM-1 , haptoglobin , serum amyloid A3 , and [clusterin] . Positive_regulation CLU IL24 21732348 2538861 differentially *regulates* soluble and nuclear [clusterin] in prostate cancer . Positive_regulation CLU IL4 9660181 517259 [Clusterin] mRNA levels were strongly *induced* in pancreatic acinar AR4-2J cells in response to various apoptotic stimuli ( i.e. , cycloheximide , staurosporine , ceramide and H2O2 ) but not with interleukin (IL)-1 , or IL-6 or heat shock , which do not induce apoptosis in AR4-2J cells . Positive_regulation CLU IL6 15519757 1328972 In contrast to adult glia , neonatal [ApoJ] secretion did not respond to IL-1 beta , IL-6 , or TNFalpha , and ApoE secretion from neonatal glia was slightly *increased* by . Positive_regulation CLU IL6 9660181 517260 [Clusterin] mRNA levels were strongly *induced* in pancreatic acinar AR4-2J cells in response to various apoptotic stimuli ( i.e. , cycloheximide , staurosporine , ceramide and H2O2 ) but not with interleukin (IL)-1 , IL-4 or or heat shock , which do not induce apoptosis in AR4-2J cells . Positive_regulation CLU JUN 21995960 2526129 Luciferase reporter assay indicates that the transcription factor complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Positive_regulation CLU MAPK1 15689620 1388508 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Positive_regulation CLU MAPK10 15689620 1388509 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Positive_regulation CLU MAPK11 15689620 1388510 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Positive_regulation CLU MAPK12 15689620 1388511 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Positive_regulation CLU MAPK13 15689620 1388512 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Positive_regulation CLU MAPK14 15689620 1388513 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Positive_regulation CLU MAPK15 15689620 1388505 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Positive_regulation CLU MAPK3 15689620 1388514 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Positive_regulation CLU MAPK4 15689620 1388515 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Positive_regulation CLU MAPK6 15689620 1388516 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Positive_regulation CLU MAPK7 15689620 1388517 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Positive_regulation CLU MAPK8 15689620 1388518 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Positive_regulation CLU MAPK9 15689620 1388519 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Positive_regulation CLU MPO 9724257 529385 Both exogenous PAF and [CLI] *induced* significant increases in activity in the stomach and duodenum . Positive_regulation CLU MYBL2 10770937 707641 Here we show that the human ApoJ/Clusterin gene contains a Myb binding site in its 5 ' flanking region , which interacts with bacterially synthesized B-MYB protein and mediates *dependent* transactivation of the [ApoJ/Clusterin] promoter in transient transfection assays . Positive_regulation CLU MYBL2 10770937 707643 Thus , *activation* of [ApoJ/Clusterin] by may be an important step in the regulation of apoptosis in normal and diseased cells . Positive_regulation CLU NFKB1 12787065 1096742 Two inhibitors , aspirin ( 10 mM ) and MG-132 ( 0.1 microM ) , *blocked* basal apoE and [apoJ] secretion as well as LPS induced apoJ secretion . Positive_regulation CLU NFKB1 12882985 1142759 Ectopic [apolipoprotein J] expression strongly *inhibited* NF-kappaB activity in human neuroblastoma cells and murine embryonic fibroblasts by stabilizing inhibitors of ( IkappaBs ) . Positive_regulation CLU NFKB1 23270201 2709662 The genes that are down-regulated in stress are cell cycle *inhibitors* , apoptosis related genes , antiproliferative cytokines and [Apo J] , the inhibitor . Positive_regulation CLU NGF 10215617 608150 and epidermal growth factor *stimulate* [clusterin] gene expression in PC12 cells . Positive_regulation CLU NPPA 7648865 319003 *increased* the cGMP content and the [ [Cl-]i] in RPE cells . Positive_regulation CLU NPPA 7648865 319004 A guanylate cyclase inhibitor , LY83583 , an inhibitor of cGMP dependent protein kinase , KT5823 , and an inhibitor of Na+/K+/2Cl- cotransporter , bumetanide , diminished or abolished the *induced* increase in [ [Cl-]i] . ANP facilitates Cl- accumulation in RPE cells , which is mediated by guanylate cyclase , cGMP dependent protein kinase , and the Na+/K+/2Cl- cotransporter . Positive_regulation CLU ODC1 7518873 265414 Stratum corneum turnover rates ( SCR ) , [cell label index (CLI)] , protein , DNA and RNA synthesis , and *induction* were determined at monthly intervals over a period of two years . Positive_regulation CLU PLAA 19258036 2062890 In addition , cisplatin stimulated plaa ( high ) cells produced less cytoprotective [clusterin] than did the cisplatin stimulated plaa ( low ) cells , and *promoted* clusterin production from both plaa ( high ) and plaa ( low ) cells . Positive_regulation CLU PON1 9109446 424850 On an atherogenic diet , activity decreased by 52 % , and [apoJ] levels *increased* 2.8-fold in fatty streak susceptible mice , C57BL/6J ( BL/6 ) , but not in fatty streak resistant mice , C3H/HeJ ( C3H ) . Positive_regulation CLU PTGS2 15331142 1290922 Not only ibuprofen , aspirin ( 100 microM ) , indomethacin ( 50 microM ) , and selective COX-1 or inhibitor ( 10 nM ketrolac or 2 microM NS398 ) also *blocked* the Abeta induced increase in neuronal [ [Cl-]i] , though such effects of COX-2 preferring drugs were limited in aggregated Abeta induced changes . Positive_regulation CLU PTGS2 22138303 2536198 With respect to the impact of *dependent* [clusterin] upregulation on NF-?B signalling , basal levels of I?B were similar in control and PCXII cells , and no evidence for a physical association between clusterin and phospho-I?B was obtained . Positive_regulation CLU PTGS2 22138303 2536199 These results indicate that *induces* [clusterin] in a 15d-PGJ ( 2 ) -dependent manner , and via activation of HSF-1 and PPAR? . Positive_regulation CLU PTTG1 23051594 2702788 We show that human gonadotroph cell pituitary tumors , unlike other secreting tumor types , express high levels of gonadotroph-specific forkhead transcription factor FOXL2 , and both and Forkhead box protein L2 (FOXL2) *stimulate* gonadotroph [clusterin (Clu)] expression . Positive_regulation CLU PTTG2 23051594 2702789 We show that human gonadotroph cell pituitary tumors , unlike other secreting tumor types , express high levels of gonadotroph-specific forkhead transcription factor FOXL2 , and both and Forkhead box protein L2 (FOXL2) *stimulate* gonadotroph [clusterin (Clu)] expression . Positive_regulation CLU RBP4 22715704 2616405 Urinary RBP , NAG and [CLU] were more sensitive than SCr and BUN as indicators for early renal injury in the order of RBP > NAG > CLU , and urinary , NAG would *increase* earlier than beta2-MG . Positive_regulation CLU RELA 12787065 1096743 Two inhibitors , aspirin ( 10 mM ) and MG-132 ( 0.1 microM ) , *blocked* basal apoE and apoJ secretion as well as LPS induced [apoJ] secretion . Positive_regulation CLU RELA 12882985 1142760 Ectopic [apolipoprotein J] expression strongly *inhibited* NF-kappaB activity in human neuroblastoma cells and murine embryonic fibroblasts by stabilizing inhibitors of ( IkappaBs ) . Positive_regulation CLU RELA 23270201 2709663 The genes that are down-regulated in stress are cell cycle *inhibitors* , apoptosis related genes , antiproliferative cytokines and [Apo J] , the inhibitor . Positive_regulation CLU SLC12A2 12904508 1119115 Our results suggest that NKCC1 functions in oligodendrocytes to maintain [ [Cl(-)]i] above electrochemical equilibrium and that is *required* for GABAergic trophic effects . Positive_regulation CLU SLC12A5 15774713 1384639 Decreases in after neuronal injuries *result* in increases in [ [Cl-]i] and enhanced neuronal excitability due to depolarizing GABA responses . Positive_regulation CLU SLC12A5 24567703 2919431 A neuron 's basal level of [ [Cl(-)]i] , as well as its Cl ( - ) extrusion capacity , is critically *dependent* on the activity of the electroneutral K ( + ) -Cl ( - ) cotransporter , a member of the SLC12 cation-Cl ( - ) cotransporter ( CCC ) family . Positive_regulation CLU SLC22A3 22896337 2682835 TGF-ß promotes and *induces* [clusterin (CLU)] expression , linking these genes to cancer metastasis . Positive_regulation CLU SRC 15689620 1388504 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Positive_regulation CLU SREBF1 21549685 2429251 *regulates* glucose stimulated hepatic [clusterin] expression . Positive_regulation CLU STAT1 18025278 1827775 We have shown earlier that is *essential* for gene transcription of [clusterin] . Positive_regulation CLU TCF12 21995960 2526117 Luciferase reporter assay indicates that the AP-1 complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Positive_regulation CLU TCF15 21995960 2526118 Luciferase reporter assay indicates that the AP-1 complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Positive_regulation CLU TCF19 21995960 2526119 Luciferase reporter assay indicates that the AP-1 complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Positive_regulation CLU TCF20 21995960 2526120 Luciferase reporter assay indicates that the AP-1 complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Positive_regulation CLU TCF21 21995960 2526121 Luciferase reporter assay indicates that the AP-1 complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Positive_regulation CLU TCF23 21995960 2526125 Luciferase reporter assay indicates that the AP-1 complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Positive_regulation CLU TCF24 21995960 2526127 Luciferase reporter assay indicates that the AP-1 complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Positive_regulation CLU TCF25 21995960 2526126 Luciferase reporter assay indicates that the AP-1 complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Positive_regulation CLU TCF3 21995960 2526122 Luciferase reporter assay indicates that the AP-1 complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Positive_regulation CLU TCF4 21995960 2526123 Luciferase reporter assay indicates that the AP-1 complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Positive_regulation CLU TCF7 21995960 2526124 Luciferase reporter assay indicates that the AP-1 complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Positive_regulation CLU TGFB1 10066375 593557 The activator protein-1 binding site partly directed the *stimulated* [clusterin] expression . Positive_regulation CLU TGFB1 10406964 629658 *regulates* [clusterin] gene expression via modulation of transcription factor c-Fos . Positive_regulation CLU TGFB1 10406964 629667 ( TGFbeta ) *induces* gene expression of the glycoprotein [clusterin] in a variety of cell types via a consensus AP-1 binding site . Positive_regulation CLU TGFB1 17274979 1704298 On the other hand , the second and most dramatic up-regulation of [clusterin] can be *due* to the potent induction by , and this up-regulation by TGF-beta1 is dependent on beta1 integrin ligand binding activity . Positive_regulation CLU TGFB1 19011008 2035043 Colocalization of increased *induced* protein ( TGFBIp ) and [Clusterin] in Fuchs endothelial corneal dystrophy . Positive_regulation CLU TGFB1 7730444 302327 However , in cultures of astrocytes that contained microglia and oligodendrocytes ( mixed glia cultures ) , *caused* a dose dependent increase in astrocytic [clusterin] mRNA levels . Positive_regulation CLU TGFB1 7730444 302328 *increased* [clusterin] protein in the conditioned medium from cultured glia , in either monotypic or mixed glial cultures . Positive_regulation CLU TGFB1 9189857 437508 Epidermal growth factor , insulin-like growth factor-1 , and *had* little or no effect on [clusterin] mRNA levels . Positive_regulation CLU TGFB2 10406964 629659 *regulates* [clusterin] gene expression via modulation of transcription factor c-Fos . Positive_regulation CLU TGFB2 10406964 629668 ( TGFbeta ) *induces* gene expression of the glycoprotein [clusterin] in a variety of cell types via a consensus AP-1 binding site . Positive_regulation CLU TGFB2 19011008 2035044 Colocalization of increased *induced* protein ( TGFBIp ) and [Clusterin] in Fuchs endothelial corneal dystrophy . Positive_regulation CLU TGFB3 10406964 629660 *regulates* [clusterin] gene expression via modulation of transcription factor c-Fos . Positive_regulation CLU TGFB3 10406964 629669 ( TGFbeta ) *induces* gene expression of the glycoprotein [clusterin] in a variety of cell types via a consensus AP-1 binding site . Positive_regulation CLU TGFB3 19011008 2035045 Colocalization of increased *induced* protein ( TGFBIp ) and [Clusterin] in Fuchs endothelial corneal dystrophy . Positive_regulation CLU TLR3 20692254 2340783 Conclusively , activation *induces* expression of cytoprotective and anti-inflammatory [CLU] by VSMC and mice , to potentially counteract atherosclerotic pathology . Positive_regulation CLU TNF 18240213 1871411 IL-1beta and *caused* increased release of chitinase 3-like protein 1 (CHI3L1) , CHI3L2 , complement factor B , matrix metalloproteinase 3 , ECM-1 , haptoglobin , serum amyloid A3 , and [clusterin] . Positive_regulation CLU TNF 22575505 2603607 [Clusterin] *induces* the secretion of and the chemotactic migration of macrophages . Positive_regulation CLU TNF 9681829 521349 Stable transfection of a unresponsive mutated IkappaB-alpha Ser 32-36 expression vector showed that *induced* MHC [Cl I] expression in an NF-kappaB dependent way while IFN-gamma did it independently of any NF-kappaB activation . Positive_regulation CLU TWIST1 22896337 2682836 In this study , we report that the transcription factor *mediates* TGF-ß induced [CLU] expression . Positive_regulation CLU TWIST1 22896337 2682837 By binding to E-boxes in the distal promoter region of CLU gene , *regulated* basal and TGF-ß induced [CLU] transcription . Positive_regulation CLU VEGFA 18652948 1942584 Plasma and sTie2 were similar in control subjects and IC but were significantly *increased* in [CLI] ( p < 0.001 vs. control or IC ) . Positive_regulation CLU XPO1 21953454 2507278 protein *mediated* regulation of nuclear [clusterin] ( nCLU ) , an ionizing radiation stimulated , Bax dependent pro-death factor . Positive_regulation CNN1 JAG1 18079106 1868198 Furthermore , suppression of expression by a small interfering RNA in the EC of young rats *reduced* alpha-smooth muscle actin and [calponin] expression and also intensified the PDGF increased growth and migration of the co-cultured VSMC . Positive_regulation CNN2 JAG1 18079106 1868199 Furthermore , suppression of expression by a small interfering RNA in the EC of young rats *reduced* alpha-smooth muscle actin and [calponin] expression and also intensified the PDGF increased growth and migration of the co-cultured VSMC . Positive_regulation CNN3 JAG1 18079106 1868200 Furthermore , suppression of expression by a small interfering RNA in the EC of young rats *reduced* alpha-smooth muscle actin and [calponin] expression and also intensified the PDGF increased growth and migration of the co-cultured VSMC . Positive_regulation CNP IL1B 8243333 236556 While interleukin (IL)-2 had no significant effect on CNP secretion , IL-1 alpha , and tumor necrosis factor (TNF)-alpha *stimulated* [CNP] secretion in a time- and dose dependent manner . Positive_regulation CNP TNF 23141169 2763645 These data indicate that lipopolysaccharide , and IL-1ß *regulate* [CNP] production from canine vascular endothelium and of the stimulants tested , IL-1ß is the predominant inducing factor . Positive_regulation CNP TNF 8243333 236555 While interleukin (IL)-2 had no significant effect on CNP secretion , IL-1 alpha , IL-1 beta and *stimulated* [CNP] secretion in a time- and dose dependent manner . Positive_regulation CNP TNF 9528978 496362 These results indicate that endothelial production of [CNP] is *stimulated* mainly by released from THP-1 derived macrophages in the coculture . Positive_regulation CNR1 EPHB2 21074588 2371416 [Cannabinoid receptor 1] *induces* a biphasic activation via multiprotein signaling complex formation of proximal kinases PKCe , Src , and Fyn in primary neurons . Positive_regulation CNR1 FOXO1 22037868 2516801 Here , we show that *upregulation* of the [cannabinoid receptor 1] ( Cnr1/Cb1 ) by in mouse primary myoblasts and ARMS cell lines , contributes to PAX3-FOXO1 phenotypes , both in vivo and in vitro . Positive_regulation CNR1 MAP2K6 12657697 1073298 Both effects were attributable to stimulation of [CB1-R] and *activation* of . Positive_regulation CNR1 TNF 22258905 2570166 Establishing cellular models for our investigations , we demonstrated that NF-?B mediated the *induced* transcription of the [cannabinoid receptor] type 1 gene in primary fetal striatal neurons from rats and the human neuroblastoma cell line SH SY5Y . Positive_regulation CNR2 TNF 22258905 2570167 Establishing cellular models for our investigations , we demonstrated that NF-?B mediated the *induced* transcription of the [cannabinoid receptor] type 1 gene in primary fetal striatal neurons from rats and the human neuroblastoma cell line SH SY5Y . Positive_regulation CNR2 TNF 24440992 2927091 In cultured RA-FLS , the expression level of [CB2R] was up-regulated by *stimulation* with IL-1ß , or lipopolysaccharide . Positive_regulation CNTF HBEGF 17822789 1817478 According to our data , *increased* transcription of IL-6 , cardiotrophin-1 (CT-1) , leukemia inhibitory factor (LIF) and [ciliary neurotrophic factor (CNTF)] . Positive_regulation CNTF IL1B 10925311 718819 Central nervous system initiated inflammation and neurotrophism in trauma : is *required* for the production of [ciliary neurotrophic factor] . Positive_regulation CNTF IL1B 11771938 899290 RT-PCR analysis demonstrated that [CNTF] increased levels of FGF-2 and nerve growth factor (NGF) mRNA and that *increased* NGF and hepatocyte growth factor mRNA levels . Positive_regulation CNTF IL1B 9753298 533901 [CNTF] potentiated IL-1beta mediated NO synthesis from RIN-5AH cells by 83 % , and *induced* islet inducible NO-synthase (iNOS) mRNA expression fourfold . Positive_regulation CNTF NGFR 8227315 235610 [CNTF] caused morphological changes , *induced* the expression of low-affinity and CD4 and increased the expression of complement receptor 3 . Positive_regulation CNTF TNF 18585018 1953360 Expression of neurotrophic factors in human primary pterygeal tissue and selective *induced* stimulation of [ciliary neurotrophic factor] in pterygeal fibroblasts . Positive_regulation CNTN2 ANKRD1 18815299 1987506 The conserved of Bcl3 *mediated* both [Tax] binding and inhibition of p300 recruitment to the HTLV-1 promoter . Positive_regulation CNTN2 IFI27 17535428 1762243 [Tax induced rapid senescence (tax-IRS)] of HeLa cells is *mediated* primarily by a dramatic stabilization of and is also accompanied by a great surge in the level of p21CIP1mRNA and protein . Positive_regulation CNTN2 TNF 12237295 1012358 Estradiol represses human T-cell leukemia virus type 1 [Tax] *activation* of gene transcription . Positive_regulation CNTN2 TNF 9261427 449050 Interestingly , culturing NT2-N cells in the presence of soluble Tax1 for as little as 5 min was sufficient to result in TNF-alpha production , indicating that the induction of in NT2-N does not *require* [Tax1] to be continually present in the culture medium . Positive_regulation CNTNAP1 MAP2K6 12429740 1036978 expression of constitutively active Raf-1 kinase or was *sufficient* to induce [p190] Rho-GAP translocation . Positive_regulation COA1 ALOX5 19754384 2140379 In addition , novel substances such as HDL related agents , cyclopentenone prostaglandins , lipoprotein associated phospholipase A(2) *inhibitors* , <5-lipoxygenase> pathway inhibitors , acyl [CoA] : cholesterol acyltransferase inhibitors , analogues of probucol and lysophosphatidic acid antagonists have been developed for the treatment of atherosclerosis as a consequence of their actions on oxidative stress and inflammation . Positive_regulation COA1 FOXO1 16997836 1640797 Increased activity *resulted* in up-regulation of hepatic peroxisome proliferator activated receptor-gamma coactivator-1beta , fatty acid synthase , and acetyl [CoA] carboxylase expression , accounting for increased hepatic fat infiltration . Positive_regulation COA1 IL1B 16122837 1454403 totally reversed Abeta evoked inhibition of ChAT activity and ACh release and *restored* control level of cytoplasmic [acetyl-CoA] but increased fraction of nonviable cells to 25 % . Positive_regulation COA3 ALOX5 19754384 2140381 In addition , novel substances such as HDL related agents , cyclopentenone prostaglandins , lipoprotein associated phospholipase A(2) *inhibitors* , <5-lipoxygenase> pathway inhibitors , acyl [CoA] : cholesterol acyltransferase inhibitors , analogues of probucol and lysophosphatidic acid antagonists have been developed for the treatment of atherosclerosis as a consequence of their actions on oxidative stress and inflammation . Positive_regulation COA3 FOXO1 16997836 1640799 Increased activity *resulted* in up-regulation of hepatic peroxisome proliferator activated receptor-gamma coactivator-1beta , fatty acid synthase , and acetyl [CoA] carboxylase expression , accounting for increased hepatic fat infiltration . Positive_regulation COA3 IL1B 16122837 1454405 totally reversed Abeta evoked inhibition of ChAT activity and ACh release and *restored* control level of cytoplasmic [acetyl-CoA] but increased fraction of nonviable cells to 25 % . Positive_regulation COA4 ALOX5 19754384 2140380 In addition , novel substances such as HDL related agents , cyclopentenone prostaglandins , lipoprotein associated phospholipase A(2) *inhibitors* , <5-lipoxygenase> pathway inhibitors , acyl [CoA] : cholesterol acyltransferase inhibitors , analogues of probucol and lysophosphatidic acid antagonists have been developed for the treatment of atherosclerosis as a consequence of their actions on oxidative stress and inflammation . Positive_regulation COA4 FOXO1 16997836 1640798 Increased activity *resulted* in up-regulation of hepatic peroxisome proliferator activated receptor-gamma coactivator-1beta , fatty acid synthase , and acetyl [CoA] carboxylase expression , accounting for increased hepatic fat infiltration . Positive_regulation COA4 IL1B 16122837 1454404 totally reversed Abeta evoked inhibition of ChAT activity and ACh release and *restored* control level of cytoplasmic [acetyl-CoA] but increased fraction of nonviable cells to 25 % . Positive_regulation COA5 ALOX5 19754384 2140382 In addition , novel substances such as HDL related agents , cyclopentenone prostaglandins , lipoprotein associated phospholipase A(2) *inhibitors* , <5-lipoxygenase> pathway inhibitors , acyl [CoA] : cholesterol acyltransferase inhibitors , analogues of probucol and lysophosphatidic acid antagonists have been developed for the treatment of atherosclerosis as a consequence of their actions on oxidative stress and inflammation . Positive_regulation COA5 FOXO1 16997836 1640800 Increased activity *resulted* in up-regulation of hepatic peroxisome proliferator activated receptor-gamma coactivator-1beta , fatty acid synthase , and acetyl [CoA] carboxylase expression , accounting for increased hepatic fat infiltration . Positive_regulation COA5 IL1B 16122837 1454406 totally reversed Abeta evoked inhibition of ChAT activity and ACh release and *restored* control level of cytoplasmic [acetyl-CoA] but increased fraction of nonviable cells to 25 % . Positive_regulation COA6 ALOX5 19754384 2140378 In addition , novel substances such as HDL related agents , cyclopentenone prostaglandins , lipoprotein associated phospholipase A(2) *inhibitors* , <5-lipoxygenase> pathway inhibitors , acyl [CoA] : cholesterol acyltransferase inhibitors , analogues of probucol and lysophosphatidic acid antagonists have been developed for the treatment of atherosclerosis as a consequence of their actions on oxidative stress and inflammation . Positive_regulation COA6 FOXO1 16997836 1640796 Increased activity *resulted* in up-regulation of hepatic peroxisome proliferator activated receptor-gamma coactivator-1beta , fatty acid synthase , and acetyl [CoA] carboxylase expression , accounting for increased hepatic fat infiltration . Positive_regulation COA6 IL1B 16122837 1454402 totally reversed Abeta evoked inhibition of ChAT activity and ACh release and *restored* control level of cytoplasmic [acetyl-CoA] but increased fraction of nonviable cells to 25 % . Positive_regulation COG2 PCSK9 22108858 2541331 *increases* the degradation of the LDL receptor , resulting in high [LDL-C] in individuals with high PCSK9 activity . Positive_regulation COG2 PCSK9 23106476 2740596 Non-HDL-C , [LDL-C] , and apoB levels were *dependent* on in nonobese subjects ( p=0.01 for each ) , but not in obese subjects ( p > 0.50 ) , Accordingly , BMI interacted negatively with PCSK9 on non-HDL-C ( p=0.028 ) and apoB ( p=0.071 ) . Positive_regulation COG2 PCSK9 25002170 2948330 The inhibition of favors LDL catabolism and *reduces* plasma [LDLC] levels . Positive_regulation COL10A1 ALOX5 20225218 2299845 [COL10A1] expression was also *suppressed* by the specific cyclooxygenase-1 ( COX-1 : SC-560 ) and <5-lipoxygenase> ( 5-LOX : MK-866 ) inhibitors , but not by COX-2 ( COX-2 inhibitor 2 ) and 12-LOX ( baicalein ) inhibitors . Positive_regulation COL10A1 IL1B 23034253 2684503 LD-1227 significantly decreased *stimulated* gene expression and production of TNFalpha , MMP-1 , MMP-13 and [Col10A1] in human chondrocytes . Positive_regulation COL17A1 CA2 11641060 872045 We previously showed that 12-O-tetradecanoylphorbol-13-acetate ( TPA ) and from low ( 0.07 mM ) to normal ( 1.87 mM ) concentration in culture medium , which were also linked to activation of protein kinase C ( PKC ) , *lead* to phosphorylation of 180 [kDa-bullous pemphigoid antigen (BPAG) 2] , but not of 230 kDa-BPAG1 , and possibly to its disassembly from hemidesmosomes in a human squamous cell carcinoma cell line ( DJM-1 ) . Positive_regulation COL18A1 FOXA1 11093745 755038 Cotransfection experiments showed that the [Col18a1] promoter 2 was *transactivated* by Sp1 and . Positive_regulation COL1A1 CTGF 15389880 1324284 We concluded that AGE induced JAK2 to increase leptin while leptin induced JAK2 to increase *induced* mitogenesis and [type I collagen] protein expression in NRK-49F cells . Positive_regulation COL1A1 CTGF 15389880 1324286 Additionally , AGE induced mitogenesis and [type I collagen] protein expression were *dependent* on leptin induced . Positive_regulation COL1A1 CTGF 15987746 1446768 Here , it was demonstrated that PTX inhibited not only TGF-beta1 induced CTGF expression but also *induced* [collagen I] ( alpha1 ) [ Col I ( alpha1 ) ] expression in normal rat kidney fibroblasts ( NRK-49F ) and alpha-smooth muscle actin expression in normal rat kidney proximal tubular epithelial cells ( NRK-52E ) . Positive_regulation COL1A1 CTGF 16143139 1451500 *stimulated* integrin alpha5beta1 dependent adhesion , migration , and [collagen I] synthesis in PSCs . Positive_regulation COL1A1 CTGF 16179645 1500680 In both asthmatic and nonasthmatic airway smooth muscle cells , TGF-beta and *led* to the production of fibronectin and [collagen I] . Positive_regulation COL1A1 CTGF 18471259 1910361 also *increased* the secretion of fibronectin and [collagen I] protein in the supernatant medium . Positive_regulation COL1A1 CTGF 18471259 1910364 Inhibition of ERK1/2 activation with PD98059 completely blocked *induced* cell proliferation as well as secretion of fibronectin and [collagen I] protein . Positive_regulation COL1A1 CTGF 19565505 2104343 This study was undertaken to investigate the *role* of in enhanced expression of [type I collagen] in bleomycin induced lung fibrosis , and to delineate the mechanisms of action underlying the effects of CTGF on Col1a2 ( collagen gene type I alpha2 ) in this mouse model and in human pulmonary fibroblasts . Positive_regulation COL1A1 CTGF 20799254 2336086 , but not CTGF alone , *led* to a two-fold enhancement of [COL1A1] expression . Positive_regulation COL1A1 CTGF 22576977 2681460 Recombinant *increased* [COL1A1] expression only in inner meniscus cells . Positive_regulation COL1A1 CTGF 23550216 2767180 Preincubation of ARPE-19 with Y27632 ( 10mmol/L ) significantly prevented or TGF- ß *induced* fibronectin ( P=0.005 , P=0.003 respectively ) , MMP-2 ( P= 0.003 , P=0.002 ) , [COL1A1] ( P=0.006 , P=0.003 ) , and COL1A2 ( P=0.006 , P=0.004 ) gene expression , but not laminin ( P=0.375 , P=0.516 ) . Positive_regulation COL1A1 CTGF 23906792 2866069 *induces* [collagen I] expression in human lung fibroblasts through the Rac1/MLK3/JNK/AP-1 pathway . Positive_regulation COL1A1 CTGF 23906792 2866073 In this study , we investigated the role of Rac1 , mixed-lineage kinase 3 (MLK3) , c-Jun N-terminal kinase (JNK) , and activator protein-1 (AP-1) in *induced* [collagen I] expression in human lung fibroblasts . Positive_regulation COL1A1 CTGF 23906792 2866075 *caused* concentration- and time dependent increases in [collagen I] expression . Positive_regulation COL1A1 CTGF 23906792 2866081 These results suggest for the first time that acting through Rac1 activates the MLK3/JNK signaling pathway , which in turn initiates AP-1 activation and recruitment of c-Jun and c-Fos to the collagen I promoter and ultimately *induces* [collagen I] expression in human lung fibroblasts . Positive_regulation COL1A1 CTGF 8751978 377239 In NRK fibroblasts , both TGF-beta and significantly *increased* the transcripts encoding [alpha 1 type I collagen] , alpha 5 integrin , and fibronectin . Positive_regulation COL1A1 CTGF 8751978 377240 *Stimulation* of [type I collagen] and fibronectin protein synthesis by TGF-beta and was confirmed by pulse labeling of cells with [ 35S ] methionine . Positive_regulation COL1A1 EDN2 12475899 1037703 induced a rapid phosphorylation of the mitogen activated protein kinase (MAPK)/ERK and *increased* [collagen I] gene activity in freshly isolated aortas . Positive_regulation COL1A1 EDN2 15033924 1237344 Since endothelin mediates the L-NAME induced fibrogenesis , the endothelin-EGFR interaction was tested in transgenic mice expressing luciferase under the control of collagen I-alpha2 promoter : In renal cortex of these animals , the *induced* [collagen I] gene activity was inhibited by an EGFR-phosphorylation inhibitor . Positive_regulation COL1A1 EDN2 15240825 1301891 Role of protein kinase Cdelta in *induced* [type I collagen] expression in cardiac myofibroblasts isolated from the site of myocardial infarction . Positive_regulation COL1A1 EDN2 18787533 2028363 AZX100 decreased the expression of CTGF and [type I collagen] *induced* by TGF-beta1 , , and lysophosphatidic acid . Positive_regulation COL1A1 EPHB2 15271999 1296236 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or [type I collagen] protein up-regulation was *inhibited* by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific inhibitor of , or SB202190 or SB203580 , specific inhibitors of p38 MAPK ; Positive_regulation COL1A1 EPHB2 23159876 2718005 Furthermore , we show that p38 or MAPK signaling is *required* for maximal transcriptional effects on [Col1a1] expression . Positive_regulation COL1A1 F2R 17492768 1772353 Activation of *induced* dynamic cytoskeletal reorganization and reduced PC-3 binding to [collagen I] , collagen IV , and laminin ( P < 0.01 ) but not fibronectin . Positive_regulation COL1A1 IL1B 9693584 523700 *stimulated* synthesis of [type I collagen] both in the absence and presence of indomethacin . Positive_regulation COL1A1 MAP2K6 15271999 1296243 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or [type I collagen] protein up-regulation was *inhibited* by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific inhibitor of , or SB202190 or SB203580 , specific inhibitors of p38 MAPK ; Positive_regulation COL1A1 MMP28 17644538 1865908 serum C-terminal cross linked telopeptide of type I collagen ( ICTP ) , an index of *mediated* [type I collagen] degradation reflecting preferential joint metabolism ; Positive_regulation COL1A1 MMP7 17644538 1865923 serum C-terminal cross linked telopeptide of type I collagen ( ICTP ) , an index of *mediated* [type I collagen] degradation reflecting preferential joint metabolism ; Positive_regulation COL1A1 NT5E 17720554 1807620 Nerve growth factor (NGF) , brain derived neurotrophic factor (BDNF) , neurotrophin (NT)-3 and *increased* the mRNA levels of dentin sialophsphoprotein , alkaline phosphatase , osteopontin , [type I collagen] and bone morphogenetic protein-2 and mineral deposition in cultures of HP cells . Positive_regulation COL1A1 PLAT 18037995 1832671 ( tPA ) *promoted* TGF-beta1 mediated alpha-SMA and [type I collagen] expression in rat kidney interstitial fibroblasts . Positive_regulation COL1A1 PLAU 10791952 714404 Bead immobilized laminin-5 and [collagen I] , two major alpha ( 3 ) beta ( 1 ) ligands , also *induced* expression . Positive_regulation COL1A1 TNF 16141211 1467193 In WT cells , and IGF-I *stimulated* [type I collagen] accumulation and DNA synthesis in an additive manner . Positive_regulation COL1A1 TNF 16141211 1467197 IGF-I , but not , *stimulated* [type I collagen] gene activation . Positive_regulation COL1A1 TNF 19298660 2056104 In contrast to epithelial cells , mesenchymal cells require 3-dimensional [type-I collagen] in *response* to to massively express MMP-9 . Positive_regulation COL1A1 TNF 21167013 2584839 AVE also markedly attenuated the increased mRNA expression of [collagen I] ( P < 0.001 ) and collagen III ( P < 0.001 ) and *inhibited* the overexpression of TGF-ß1 ( P < 0.05 ) and ( P < 0.05 ) compared to the control group . Positive_regulation COL1A1 TNF 7622181 315735 In addition , [type I collagen] could also *induce* IL-1 , IL-6 and in these samples from RA and OD patients but was less potent than type II collagen . Positive_regulation COL1A2 CTGF 15389880 1324285 We concluded that AGE induced JAK2 to increase leptin while leptin induced JAK2 to increase *induced* mitogenesis and [type I collagen] protein expression in NRK-49F cells . Positive_regulation COL1A2 CTGF 15389880 1324288 Additionally , AGE induced mitogenesis and [type I collagen] protein expression were *dependent* on leptin induced . Positive_regulation COL1A2 CTGF 15987746 1446770 Here , it was demonstrated that PTX inhibited not only TGF-beta1 induced CTGF expression but also *induced* [collagen I] ( alpha1 ) [ Col I ( alpha1 ) ] expression in normal rat kidney fibroblasts ( NRK-49F ) and alpha-smooth muscle actin expression in normal rat kidney proximal tubular epithelial cells ( NRK-52E ) . Positive_regulation COL1A2 CTGF 16143139 1451502 *stimulated* integrin alpha5beta1 dependent adhesion , migration , and [collagen I] synthesis in PSCs . Positive_regulation COL1A2 CTGF 16179645 1500681 In both asthmatic and nonasthmatic airway smooth muscle cells , TGF-beta and *led* to the production of fibronectin and [collagen I] . Positive_regulation COL1A2 CTGF 18471259 1910362 also *increased* the secretion of fibronectin and [collagen I] protein in the supernatant medium . Positive_regulation COL1A2 CTGF 18471259 1910366 Inhibition of ERK1/2 activation with PD98059 completely blocked *induced* cell proliferation as well as secretion of fibronectin and [collagen I] protein . Positive_regulation COL1A2 CTGF 19565505 2104344 This study was undertaken to investigate the *role* of in enhanced expression of [type I collagen] in bleomycin induced lung fibrosis , and to delineate the mechanisms of action underlying the effects of CTGF on Col1a2 ( collagen gene type I alpha2 ) in this mouse model and in human pulmonary fibroblasts . Positive_regulation COL1A2 CTGF 19565505 2104349 In vitro , inhibition of by specific small interfering RNA and neutralizing antibodies *reduced* the collagen protein expression and [Col1a2] promoter activity . Positive_regulation COL1A2 CTGF 21760921 2456301 Recombinant potently *stimulated* collagen mRNA levels and upregulated activity of the [COL1A2] promoter , however CCN2 was a weak inducer of collagen protein levels . Positive_regulation COL1A2 CTGF 23550216 2767181 Preincubation of ARPE-19 with Y27632 ( 10mmol/L ) significantly prevented or TGF- ß *induced* fibronectin ( P=0.005 , P=0.003 respectively ) , MMP-2 ( P= 0.003 , P=0.002 ) , COL1A1 ( P=0.006 , P=0.003 ) , and [COL1A2] ( P=0.006 , P=0.004 ) gene expression , but not laminin ( P=0.375 , P=0.516 ) . Positive_regulation COL1A2 CTGF 23906792 2866070 *induces* [collagen I] expression in human lung fibroblasts through the Rac1/MLK3/JNK/AP-1 pathway . Positive_regulation COL1A2 CTGF 23906792 2866074 In this study , we investigated the role of Rac1 , mixed-lineage kinase 3 (MLK3) , c-Jun N-terminal kinase (JNK) , and activator protein-1 (AP-1) in *induced* [collagen I] expression in human lung fibroblasts . Positive_regulation COL1A2 CTGF 23906792 2866076 *caused* concentration- and time dependent increases in [collagen I] expression . Positive_regulation COL1A2 CTGF 23906792 2866082 These results suggest for the first time that acting through Rac1 activates the MLK3/JNK signaling pathway , which in turn initiates AP-1 activation and recruitment of c-Jun and c-Fos to the collagen I promoter and ultimately *induces* [collagen I] expression in human lung fibroblasts . Positive_regulation COL1A2 CTGF 8751978 377241 *Stimulation* of [type I collagen] and fibronectin protein synthesis by TGF-beta and was confirmed by pulse labeling of cells with [ 35S ] methionine . Positive_regulation COL1A2 EDN2 12475899 1037706 induced a rapid phosphorylation of the mitogen activated protein kinase (MAPK)/ERK and *increased* [collagen I] gene activity in freshly isolated aortas . Positive_regulation COL1A2 EDN2 15033924 1237348 Since endothelin mediates the L-NAME induced fibrogenesis , the endothelin-EGFR interaction was tested in transgenic mice expressing luciferase under the control of collagen I-alpha2 promoter : In renal cortex of these animals , the *induced* [collagen I] gene activity was inhibited by an EGFR-phosphorylation inhibitor . Positive_regulation COL1A2 EDN2 15240825 1301895 Role of protein kinase Cdelta in *induced* [type I collagen] expression in cardiac myofibroblasts isolated from the site of myocardial infarction . Positive_regulation COL1A2 EDN2 18787533 2028367 AZX100 decreased the expression of CTGF and [type I collagen] *induced* by TGF-beta1 , , and lysophosphatidic acid . Positive_regulation COL1A2 EPHB2 15271999 1296245 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or [type I collagen] protein up-regulation was *inhibited* by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific inhibitor of , or SB202190 or SB203580 , specific inhibitors of p38 MAPK ; Positive_regulation COL1A2 EPHB2 24080014 2863352 Collectively , these data suggest that Serine-204 phosphorylation in the Smad3LR is a critical event by which *enhances* Smad3 mediated [COL1A2] promoter activity in mesenchymal cells . Positive_regulation COL1A2 F2R 17492768 1772354 Activation of *induced* dynamic cytoskeletal reorganization and reduced PC-3 binding to [collagen I] , collagen IV , and laminin ( P < 0.01 ) but not fibronectin . Positive_regulation COL1A2 IL1B 9693584 523701 *stimulated* synthesis of [type I collagen] both in the absence and presence of indomethacin . Positive_regulation COL1A2 MAP2K6 15271999 1296252 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or [type I collagen] protein up-regulation was *inhibited* by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific inhibitor of , or SB202190 or SB203580 , specific inhibitors of p38 MAPK ; Positive_regulation COL1A2 MMP28 17644538 1865930 serum C-terminal cross linked telopeptide of type I collagen ( ICTP ) , an index of *mediated* [type I collagen] degradation reflecting preferential joint metabolism ; Positive_regulation COL1A2 MMP7 17644538 1865945 serum C-terminal cross linked telopeptide of type I collagen ( ICTP ) , an index of *mediated* [type I collagen] degradation reflecting preferential joint metabolism ; Positive_regulation COL1A2 NT5E 17720554 1807623 Nerve growth factor (NGF) , brain derived neurotrophic factor (BDNF) , neurotrophin (NT)-3 and *increased* the mRNA levels of dentin sialophsphoprotein , alkaline phosphatase , osteopontin , [type I collagen] and bone morphogenetic protein-2 and mineral deposition in cultures of HP cells . Positive_regulation COL1A2 PLAT 18037995 1832672 ( tPA ) *promoted* TGF-beta1 mediated alpha-SMA and [type I collagen] expression in rat kidney interstitial fibroblasts . Positive_regulation COL1A2 PLAU 10791952 714405 Bead immobilized laminin-5 and [collagen I] , two major alpha ( 3 ) beta ( 1 ) ligands , also *induced* expression . Positive_regulation COL1A2 SPHK1 12515830 1063823 Conversely , overexpression of ( SPHK1 ) *inhibited* basal and TGF-beta stimulated [COL1A2] promoter activity . Positive_regulation COL1A2 TNF 16141211 1467195 In WT cells , and IGF-I *stimulated* [type I collagen] accumulation and DNA synthesis in an additive manner . Positive_regulation COL1A2 TNF 16141211 1467199 IGF-I , but not , *stimulated* [type I collagen] gene activation . Positive_regulation COL1A2 TNF 19298660 2056105 In contrast to epithelial cells , mesenchymal cells require 3-dimensional [type-I collagen] in *response* to to massively express MMP-9 . Positive_regulation COL1A2 TNF 21167013 2584840 AVE also markedly attenuated the increased mRNA expression of [collagen I] ( P < 0.001 ) and collagen III ( P < 0.001 ) and *inhibited* the overexpression of TGF-ß1 ( P < 0.05 ) and ( P < 0.05 ) compared to the control group . Positive_regulation COL1A2 TNF 7622181 315737 In addition , [type I collagen] could also *induce* IL-1 , IL-6 and in these samples from RA and OD patients but was less potent than type II collagen . Positive_regulation COL2A1 CCND1 17454300 1730133 In turn , overexpression of *suppressed* [type II collagen] expression . Positive_regulation COL2A1 CCND1 17454300 1730136 Our results collectively indicate that complex *regulates* [type II collagen] expression in articular chondrocytes . Positive_regulation COL2A1 CHI3L1 16949314 1682517 *induced* both SOX9 and [type II collagen] synthesis . Positive_regulation COL2A1 CTGF 20819546 2318402 Compared to the control , *promoted* the synthesis of [collagen type II] and proteoglycan . Positive_regulation COL2A1 CTGF 20819546 2318406 expression can also *enhance* [collagen type II] protein synthesis . Positive_regulation COL2A1 CTGF 21928342 2539150 In this study we demonstrate that Wif-1 is capable to interfere with *dependent* induction of Acan and [Col2a1] gene expression in primary murine chondrocytes . Positive_regulation COL2A1 CTGF 21933582 2487355 Both and TIMP1 transfected cell transplantation helps to maintain disc height , and *promotes* the biosynthesis of [type II collagen] and proteoglycan in intervertebral discs , reversing the degeneration of intervertebral discs . Positive_regulation COL2A1 EPHB2 16622376 1551687 Moreover , inhibition of activity , in the presence TGF-beta3 , *resulted* in suppression of [collagen Type II] , aggrecan , TGF-beta-RI , TGF-beta-RII and TGF-beta-RIII mRNA expression . Positive_regulation COL2A1 EPHB2 19823173 2187248 Selective inhibition of and Rho/ROCK activation greatly reduced or completely *prevented* excess [type II collagen] and aggrecan degradation in response to TGFalpha . Positive_regulation COL2A1 IL1B 11037878 741250 The p38 MAPK-selective inhibitor , SB203580 , partially reversed *induced* inhibition of COL2A1 mRNA levels and [COL2A1-luciferase] reporter gene expression . Positive_regulation COL2A1 IL1B 16736518 1570648 Surface bound [anti-type II collagen] containing immune complexes *induce* production of tumor necrosis factor alpha , , and interleukin-8 from peripheral blood monocytes via Fc gamma receptor IIA : a potential pathophysiologic mechanism for humoral anti-type II collagen immunity in arthritis . Positive_regulation COL2A1 IL1B 7622181 315727 In the other RA patients with lower SF monocyte count , [type II collagen] *induced* significantly higher than the medium control levels by SF MNC ( P < 0.01 ) or that of the other diseases ( P < 0.01 ) . Positive_regulation COL2A1 MAP2K6 15250049 1271443 Type II collagen mRNA expression was expressed strongly during chondrogenesis and inhibition ( U0126 ) *resulted* in complete down-regulation of [type II collagen] . Positive_regulation COL2A1 MAP2K6 19823173 2187254 Selective inhibition of and Rho/ROCK activation greatly reduced or completely *prevented* excess [type II collagen] and aggrecan degradation in response to TGFalpha . Positive_regulation COL2A1 MMP28 16563811 1582438 Inhibition of activity *reduced* both proteoglycan loss and [type II collagen] degradation . Positive_regulation COL2A1 MMP28 18513402 1939637 Cartilage degradation was measured by *mediated* [type II collagen] degradation ( CTX-II ) , and MMP and aggrecanase mediated aggrecan degradation by detecting the 342FFGVG and 374ARGSV neoepitopes . Positive_regulation COL2A1 MMP7 16563811 1582453 Inhibition of activity *reduced* both proteoglycan loss and [type II collagen] degradation . Positive_regulation COL2A1 MMP7 18513402 1939652 Cartilage degradation was measured by *mediated* [type II collagen] degradation ( CTX-II ) , and MMP and aggrecanase mediated aggrecan degradation by detecting the 342FFGVG and 374ARGSV neoepitopes . Positive_regulation COL3A1 ANGPT1 17906098 1830123 enzyme activity increased ( 28 % ) in the S group ( 33 % ) , and [type III collagen] synthesis *increased* ( 56 % ) in T+S but not in T group . Positive_regulation COL3A1 MMP28 20666994 2340608 Serum levels of the neo-epitope CO3-610C ( *mediated* [type III collagen] degradation ) were determined with an ELISA at 14 and 28 days post-surgery . Positive_regulation COL3A1 MMP7 20666994 2340623 Serum levels of the neo-epitope CO3-610C ( *mediated* [type III collagen] degradation ) were determined with an ELISA at 14 and 28 days post-surgery . Positive_regulation COL4A1 CTGF 15536170 1374817 ( 20 ng/ml ) *induced* fibronectin and [collagen IV] secretion in primary cultures of human proximal tubule cells (PTC) and cortical fibroblasts ( CF ) compared with control values ( P < 0.005 in all cases ) . Positive_regulation COL4A1 CTGF 15536170 1374840 TGF-beta(1) *induced* a greater increase in fibronectin and [collagen IV] secretion in both PTC ( P < 0.01 ) and CF ( P < 0.01 ) compared with that observed with alone . Positive_regulation COL4A1 CTGF 16204411 1517631 Our studies further demonstrate that in the CTGF gene silenced cells , partially *mediates* TGF-beta(1) induced fibronectin and [collagen IV] secretion . Positive_regulation COL4A1 CTGF 16528248 1536297 significantly *induced* cell hypertrophy , increased fibronectin , and [collagen IV] secretion in PTCs and CFs . Positive_regulation COL4A1 F2R 17492768 1772355 Activation of *induced* dynamic cytoskeletal reorganization and reduced PC-3 binding to collagen I , [collagen IV] , and laminin ( P < 0.01 ) but not fibronectin . Positive_regulation COL4A1 MMP28 17850869 1842828 Recently , we postulated that an endogenous expressed in the lepidopteran model Galleria mellonella during metamorphosis *causes* degradation of [collagen-IV] , which in turn results in activation of innate immunity . Positive_regulation COL4A1 MMP7 17850869 1842843 Recently , we postulated that an endogenous expressed in the lepidopteran model Galleria mellonella during metamorphosis *causes* degradation of [collagen-IV] , which in turn results in activation of innate immunity . Positive_regulation COL4A1 PLAU 11835393 911360 Plasminogen dependent [ 3H ] [-collagen IV] degradation was *inhibited* by inhibitor of ( amiloride ) and MMP ( phenanthroline ) and by antibodies against uPA or MMP-9 or alphavbeta6 integrin , indicating the involvement of alphavbeta6 integrin , uPA and MMP-9 in the process . Positive_regulation COL4A1 PLAU 14729061 1198289 We now show that the endocytic transmembrane glycoprotein receptor associated protein ( uPARAP/endo180 ) *directs* [collagen IV] for lysosomal delivery and degradation . Positive_regulation COL4A1 TGM2 17223863 1689274 Inhibition of also resulted in *loss* of basement membrane [collagen IV] . Positive_regulation COL4A2 CTGF 15536170 1374818 ( 20 ng/ml ) *induced* fibronectin and [collagen IV] secretion in primary cultures of human proximal tubule cells (PTC) and cortical fibroblasts ( CF ) compared with control values ( P < 0.005 in all cases ) . Positive_regulation COL4A2 CTGF 15536170 1374842 TGF-beta(1) *induced* a greater increase in fibronectin and [collagen IV] secretion in both PTC ( P < 0.01 ) and CF ( P < 0.01 ) compared with that observed with alone . Positive_regulation COL4A2 CTGF 16204411 1517633 Our studies further demonstrate that in the CTGF gene silenced cells , partially *mediates* TGF-beta(1) induced fibronectin and [collagen IV] secretion . Positive_regulation COL4A2 CTGF 16528248 1536298 significantly *induced* cell hypertrophy , increased fibronectin , and [collagen IV] secretion in PTCs and CFs . Positive_regulation COL4A2 F2R 17492768 1772356 Activation of *induced* dynamic cytoskeletal reorganization and reduced PC-3 binding to collagen I , [collagen IV] , and laminin ( P < 0.01 ) but not fibronectin . Positive_regulation COL4A2 MMP28 17850869 1842850 Recently , we postulated that an endogenous expressed in the lepidopteran model Galleria mellonella during metamorphosis *causes* degradation of [collagen-IV] , which in turn results in activation of innate immunity . Positive_regulation COL4A2 MMP7 17850869 1842865 Recently , we postulated that an endogenous expressed in the lepidopteran model Galleria mellonella during metamorphosis *causes* degradation of [collagen-IV] , which in turn results in activation of innate immunity . Positive_regulation COL4A2 PLAU 11835393 911361 Plasminogen dependent [ 3H ] [-collagen IV] degradation was *inhibited* by inhibitor of ( amiloride ) and MMP ( phenanthroline ) and by antibodies against uPA or MMP-9 or alphavbeta6 integrin , indicating the involvement of alphavbeta6 integrin , uPA and MMP-9 in the process . Positive_regulation COL4A2 PLAU 14729061 1198294 We now show that the endocytic transmembrane glycoprotein receptor associated protein ( uPARAP/endo180 ) *directs* [collagen IV] for lysosomal delivery and degradation . Positive_regulation COL4A2 TGM2 17223863 1689281 Inhibition of also *resulted* in loss of basement membrane [collagen IV] . Positive_regulation COL4A3 CTGF 15536170 1374819 ( 20 ng/ml ) *induced* fibronectin and [collagen IV] secretion in primary cultures of human proximal tubule cells (PTC) and cortical fibroblasts ( CF ) compared with control values ( P < 0.005 in all cases ) . Positive_regulation COL4A3 CTGF 15536170 1374844 TGF-beta(1) *induced* a greater increase in fibronectin and [collagen IV] secretion in both PTC ( P < 0.01 ) and CF ( P < 0.01 ) compared with that observed with alone . Positive_regulation COL4A3 CTGF 16204411 1517635 Our studies further demonstrate that in the CTGF gene silenced cells , partially *mediates* TGF-beta(1) induced fibronectin and [collagen IV] secretion . Positive_regulation COL4A3 CTGF 16528248 1536299 significantly *induced* cell hypertrophy , increased fibronectin , and [collagen IV] secretion in PTCs and CFs . Positive_regulation COL4A3 F2R 17492768 1772357 Activation of *induced* dynamic cytoskeletal reorganization and reduced PC-3 binding to collagen I , [collagen IV] , and laminin ( P < 0.01 ) but not fibronectin . Positive_regulation COL4A3 MMP28 17850869 1842872 Recently , we postulated that an endogenous expressed in the lepidopteran model Galleria mellonella during metamorphosis *causes* degradation of [collagen-IV] , which in turn results in activation of innate immunity . Positive_regulation COL4A3 MMP7 17850869 1842887 Recently , we postulated that an endogenous expressed in the lepidopteran model Galleria mellonella during metamorphosis *causes* degradation of [collagen-IV] , which in turn results in activation of innate immunity . Positive_regulation COL4A3 PLAU 11835393 911362 Plasminogen dependent [ 3H ] [-collagen IV] degradation was *inhibited* by inhibitor of ( amiloride ) and MMP ( phenanthroline ) and by antibodies against uPA or MMP-9 or alphavbeta6 integrin , indicating the involvement of alphavbeta6 integrin , uPA and MMP-9 in the process . Positive_regulation COL4A3 PLAU 14729061 1198299 We now show that the endocytic transmembrane glycoprotein receptor associated protein ( uPARAP/endo180 ) *directs* [collagen IV] for lysosomal delivery and degradation . Positive_regulation COL4A3 TGM2 17223863 1689288 Inhibition of also resulted in *loss* of basement membrane [collagen IV] . Positive_regulation COL4A4 CTGF 15536170 1374820 ( 20 ng/ml ) *induced* fibronectin and [collagen IV] secretion in primary cultures of human proximal tubule cells (PTC) and cortical fibroblasts ( CF ) compared with control values ( P < 0.005 in all cases ) . Positive_regulation COL4A4 CTGF 15536170 1374846 TGF-beta(1) *induced* a greater increase in fibronectin and [collagen IV] secretion in both PTC ( P < 0.01 ) and CF ( P < 0.01 ) compared with that observed with alone . Positive_regulation COL4A4 CTGF 16204411 1517637 Our studies further demonstrate that in the CTGF gene silenced cells , partially *mediates* TGF-beta(1) induced fibronectin and [collagen IV] secretion . Positive_regulation COL4A4 CTGF 16528248 1536300 significantly *induced* cell hypertrophy , increased fibronectin , and [collagen IV] secretion in PTCs and CFs . Positive_regulation COL4A4 F2R 17492768 1772358 Activation of *induced* dynamic cytoskeletal reorganization and reduced PC-3 binding to collagen I , [collagen IV] , and laminin ( P < 0.01 ) but not fibronectin . Positive_regulation COL4A4 MMP28 17850869 1842894 Recently , we postulated that an endogenous expressed in the lepidopteran model Galleria mellonella during metamorphosis *causes* degradation of [collagen-IV] , which in turn results in activation of innate immunity . Positive_regulation COL4A4 MMP7 17850869 1842909 Recently , we postulated that an endogenous expressed in the lepidopteran model Galleria mellonella during metamorphosis *causes* degradation of [collagen-IV] , which in turn results in activation of innate immunity . Positive_regulation COL4A4 PLAU 11835393 911363 Plasminogen dependent [ 3H ] [-collagen IV] degradation was *inhibited* by inhibitor of ( amiloride ) and MMP ( phenanthroline ) and by antibodies against uPA or MMP-9 or alphavbeta6 integrin , indicating the involvement of alphavbeta6 integrin , uPA and MMP-9 in the process . Positive_regulation COL4A4 PLAU 14729061 1198304 We now show that the endocytic transmembrane glycoprotein receptor associated protein ( uPARAP/endo180 ) *directs* [collagen IV] for lysosomal delivery and degradation . Positive_regulation COL4A4 TGM2 17223863 1689295 Inhibition of also resulted in *loss* of basement membrane [collagen IV] . Positive_regulation COL4A5 CTGF 15536170 1374821 ( 20 ng/ml ) *induced* fibronectin and [collagen IV] secretion in primary cultures of human proximal tubule cells (PTC) and cortical fibroblasts ( CF ) compared with control values ( P < 0.005 in all cases ) . Positive_regulation COL4A5 CTGF 15536170 1374848 TGF-beta(1) *induced* a greater increase in fibronectin and [collagen IV] secretion in both PTC ( P < 0.01 ) and CF ( P < 0.01 ) compared with that observed with alone . Positive_regulation COL4A5 CTGF 16204411 1517639 Our studies further demonstrate that in the CTGF gene silenced cells , partially *mediates* TGF-beta(1) induced fibronectin and [collagen IV] secretion . Positive_regulation COL4A5 CTGF 16522717 1531333 As assessed by RT-PCR or Western blotting , ( 3 ) *stimulated* production of fibronectin and [pro-collagen type IV(alpha5)] , both of which are downstream components of HSC mediated fibrogenesis and which are constituents of high density matrix in fibrotic lesions . Positive_regulation COL4A5 CTGF 16528248 1536301 significantly *induced* cell hypertrophy , increased fibronectin , and [collagen IV] secretion in PTCs and CFs . Positive_regulation COL4A5 F2R 17492768 1772359 Activation of *induced* dynamic cytoskeletal reorganization and reduced PC-3 binding to collagen I , [collagen IV] , and laminin ( P < 0.01 ) but not fibronectin . Positive_regulation COL4A5 MMP28 17850869 1842916 Recently , we postulated that an endogenous expressed in the lepidopteran model Galleria mellonella during metamorphosis *causes* degradation of [collagen-IV] , which in turn results in activation of innate immunity . Positive_regulation COL4A5 MMP7 17850869 1842931 Recently , we postulated that an endogenous expressed in the lepidopteran model Galleria mellonella during metamorphosis *causes* degradation of [collagen-IV] , which in turn results in activation of innate immunity . Positive_regulation COL4A5 PLAU 11835393 911364 Plasminogen dependent [ 3H ] [-collagen IV] degradation was *inhibited* by inhibitor of ( amiloride ) and MMP ( phenanthroline ) and by antibodies against uPA or MMP-9 or alphavbeta6 integrin , indicating the involvement of alphavbeta6 integrin , uPA and MMP-9 in the process . Positive_regulation COL4A5 PLAU 14729061 1198309 We now show that the endocytic transmembrane glycoprotein receptor associated protein ( uPARAP/endo180 ) *directs* [collagen IV] for lysosomal delivery and degradation . Positive_regulation COL4A5 SLC2A10 20639396 2316829 Mutations in alter angiogenesis and *cause* [arterial tortuosity syndrome (ATS)] ; Positive_regulation COL4A5 TGM2 17223863 1689302 Inhibition of also *resulted* in loss of basement membrane [collagen IV] . Positive_regulation COL4A6 CTGF 15536170 1374822 ( 20 ng/ml ) *induced* fibronectin and [collagen IV] secretion in primary cultures of human proximal tubule cells (PTC) and cortical fibroblasts ( CF ) compared with control values ( P < 0.005 in all cases ) . Positive_regulation COL4A6 CTGF 15536170 1374850 TGF-beta(1) *induced* a greater increase in fibronectin and [collagen IV] secretion in both PTC ( P < 0.01 ) and CF ( P < 0.01 ) compared with that observed with alone . Positive_regulation COL4A6 CTGF 16204411 1517641 Our studies further demonstrate that in the CTGF gene silenced cells , partially *mediates* TGF-beta(1) induced fibronectin and [collagen IV] secretion . Positive_regulation COL4A6 CTGF 16528248 1536302 significantly *induced* cell hypertrophy , increased fibronectin , and [collagen IV] secretion in PTCs and CFs . Positive_regulation COL4A6 F2R 17492768 1772360 Activation of *induced* dynamic cytoskeletal reorganization and reduced PC-3 binding to collagen I , [collagen IV] , and laminin ( P < 0.01 ) but not fibronectin . Positive_regulation COL4A6 MMP28 17850869 1842938 Recently , we postulated that an endogenous expressed in the lepidopteran model Galleria mellonella during metamorphosis *causes* degradation of [collagen-IV] , which in turn results in activation of innate immunity . Positive_regulation COL4A6 MMP7 17850869 1842953 Recently , we postulated that an endogenous expressed in the lepidopteran model Galleria mellonella during metamorphosis *causes* degradation of [collagen-IV] , which in turn results in activation of innate immunity . Positive_regulation COL4A6 PLAU 11835393 911365 Plasminogen dependent [ 3H ] [-collagen IV] degradation was *inhibited* by inhibitor of ( amiloride ) and MMP ( phenanthroline ) and by antibodies against uPA or MMP-9 or alphavbeta6 integrin , indicating the involvement of alphavbeta6 integrin , uPA and MMP-9 in the process . Positive_regulation COL4A6 PLAU 14729061 1198314 We now show that the endocytic transmembrane glycoprotein receptor associated protein ( uPARAP/endo180 ) *directs* [collagen IV] for lysosomal delivery and degradation . Positive_regulation COL4A6 TGM2 17223863 1689309 Inhibition of also *resulted* in loss of basement membrane [collagen IV] . Positive_regulation COL5A1 MMP28 22382088 2587325 AS patients had highly elevated levels of *mediated* [type V collagen] degradation . Positive_regulation COL5A1 MMP7 22382088 2587340 AS patients had highly elevated levels of *mediated* [type V collagen] degradation . Positive_regulation COL5A2 MMP28 22382088 2587347 AS patients had highly elevated levels of *mediated* [type V collagen] degradation . Positive_regulation COL5A2 MMP7 22382088 2587362 AS patients had highly elevated levels of *mediated* [type V collagen] degradation . Positive_regulation COL6A1 MMP28 21935455 2487424 *mediated* degradation of [type VI collagen] is highly associated with liver fibrosis -- identification and validation of a novel biochemical marker assay . Positive_regulation COL6A1 MMP7 21935455 2487439 *mediated* degradation of [type VI collagen] is highly associated with liver fibrosis -- identification and validation of a novel biochemical marker assay . Positive_regulation COL6A2 MMP28 21935455 2487446 *mediated* degradation of [type VI collagen] is highly associated with liver fibrosis -- identification and validation of a novel biochemical marker assay . Positive_regulation COL6A2 MMP7 21935455 2487461 *mediated* degradation of [type VI collagen] is highly associated with liver fibrosis -- identification and validation of a novel biochemical marker assay . Positive_regulation COL7A1 IL1B 15810887 1392144 Finally , we demonstrated that TNF-alpha and *enhanced* the TGF-beta mediated up-regulation of [COL7A1] expression in HaCaT keratinocytes , suggesting that the combination of TGF-beta and TNF-alpha or IL-1beta induces a signaling pathway that is completely different from that induced by either pro-inflammatory cytokine alone . Positive_regulation COL7A1 TNF 15810887 1392143 Finally , we demonstrated that and IL-1beta *enhanced* the TGF-beta mediated up-regulation of [COL7A1] expression in HaCaT keratinocytes , suggesting that the combination of TGF-beta and TNF-alpha or IL-1beta induces a signaling pathway that is completely different from that induced by either pro-inflammatory cytokine alone . Positive_regulation COL7A1 TNF 8276802 247229 Interestingly , IL-1 , and LR *had* additive effects with transforming growth factor-beta ( TGF-beta ) on [type VII collagen] gene expression , whereas they counteracted the up-regulatory effect of TGF-beta on type I collagen gene expression . Positive_regulation COMP IL1B 18485748 1971686 Specific blocking antibodies against ADAMTS-7 and ADAMTS-12 dramatically inhibited TNF-alpha- or *induced* [COMP] degradation in the cultured cartilage explants . Positive_regulation COMP IL1B 18485748 1971691 The suppression of ADAMTS-7 or ADAMTS-12 expression by siRNA silencing in the human chondrocytes also prevented TNF-alpha- or *induced* [COMP] degradation . Positive_regulation COMP IL1B 19098927 2018714 In addition , antibodies against ADAMTS-7 or ADAMTS-12 dramatically inhibit tumor necrosis factor induced and *induced* [COMP] degradation in cartilage explants . Positive_regulation COMP TNF 20506400 2283905 The role of GEP in inhibiting *induced* ADAMTS-7/ADAMTS-12 expression and [COMP] degradation in cartilage explants was also analyzed . Positive_regulation COMT MAOA 1421124 202098 A new [COMT] *inhibitor* , nitecapone ( OR-462 ) or clorgyline , a inhibitor , was infused into the 3rd brain ventricle ( i.c.v. ) of conscious male rats . Positive_regulation CORO2A INPP4B 21224358 2379444 Optimal induction of by an androgen receptor *required* the expression of the transcriptional coactivator [NCoR] . Positive_regulation CORO2A TLR7 21849441 2486197 Treatment with PPAR? and LXR ligands , but not GR ligands , prevented this *induced* clearance of [NCoR] from the LTR . Positive_regulation CORT HSD11B2 16397092 1539927 These changes included an upregulation of CRH in the hypothalamus , a downregulation of MR with a concomitant upregulation of <11beta-HSD-1> in the hippocampus , and an *increase* in circulating levels of both ACTH and [CORT] relative to unrestrained control animals . Positive_regulation CORT IL1B 12907841 1030952 There was no significant difference in *stimulated* plasma ACTH or [CORT] levels between wild-type and knockout mice . Positive_regulation CORT IL1B 8243265 236509 Recombinant rat ( rIL-1 beta ) when given ip *resulted* in dose dependent increases in plasma ACTH , [CORT] , and IL-6 concentrations . Positive_regulation COX4I1 PGC 21081705 2376865 Our findings reveal that the CCA induced increases in [COX-IV] protein and overall mitochondrial content , using both COX activity and organelle fluorescence , are *dependent* on . Positive_regulation COX4I1 PGC 21486805 2417689 Over-expression of also *increased* Cpt-1ß , [Cox4] and Vegf mRNA by 6.2- , 2.0- and 2.0-fold , respectively . Positive_regulation CP FOXO1 21185807 2385971 *stimulates* [ceruloplasmin] promoter activity in human hepatoma cells treated with IL-6 . Positive_regulation CP IL1B 12951659 1137389 Astrocytic [ceruloplasmin] expression , which is *induced* by and by traumatic brain injury , increases in the absence of the IL-1 type 1 receptor . Positive_regulation CP TNF 1377744 190535 The absolute increase in [ceruloplasmin] in *response* to was enhanced in rats fed the alanine supplemented diet relative to those fed the 20 % casein diet . Positive_regulation CP TNF 2460085 98225 Human recombinant tumour necrosis factor ( ) *induced* a dose dependent increase in synthesis of haptoglobin and [ceruloplasmin] . Positive_regulation CPA4 LXN 15738388 1383022 Latexin , alias , *inhibits* human [CPA4] ( hCPA4 ) , whose expression is induced in prostate cancer cells after treatment with histone deacetylase inhibitors . Positive_regulation CPA4 NEUROG3 16896938 1607812 Adenovirus mediated expression of ( also known as Neurog3 ) and Ptf1a in these cells *induced* expression of insulin and somatostatin , and of [carboxypeptidase A] , respectively . Positive_regulation CPA4 NTS 9652308 515827 Inhibition of *stimulated* mast cell secretion and [carboxypeptidase A] activity by the peptide inhibitor of carboxypeptidase A and neurotensin-receptor antagonist SR 48692 . Positive_regulation CPA4 PTF1A 16896938 1607813 Adenovirus mediated expression of ngn3 ( also known as Neurog3 ) and in these cells *induced* expression of insulin and somatostatin , and of [carboxypeptidase A] , respectively . Positive_regulation CPB1 F2R 9516134 493080 Several investigators have shown that during [cardiopulmonary bypass (CPB)] surgery and also during platelet *activation* in vitro by thrombin or activating peptide ( TRAP ) GPIb disappears from the platelet surface . Positive_regulation CPB1 LBP 9118690 423663 Also , [CPB] *induced* a gradual increase of the acute-phase reactant , which was identical in the noncoated and heparin coated groups . Positive_regulation CPB1 TNF 12212211 767356 Both [CPB] and operative stimulus *induce* the increase of cytokine after CPB . Positive_regulation CPB2 F2R 9516134 493081 Several investigators have shown that during [cardiopulmonary bypass (CPB)] surgery and also during platelet *activation* in vitro by thrombin or activating peptide ( TRAP ) GPIb disappears from the platelet surface . Positive_regulation CPB2 LBP 9118690 423664 Also , [CPB] *induced* a gradual increase of the acute-phase reactant , which was identical in the noncoated and heparin coated groups . Positive_regulation CPB2 TNF 12212211 767357 Both [CPB] and operative stimulus *induce* the increase of cytokine after CPB . Positive_regulation CPD MAP2K6 11804669 903321 PD 98059 , a inhibitor , and glutathione , an anti-thiol-oxidant , not only *blocked* [Cpd] 5-induced ERK phosphorylation , but also antagonized the activation of CPP-32 , the altered Bcl-2/Bax expression , and DNA fragmentation . Positive_regulation CPNE1 TNF 14674885 1211101 was found to greatly *enhance* the expression of endogenous [copine I] , and the responsiveness of the TNF-alpha signalling pathway to muscarinic stimulation increased in parallel with the increased copine I expression . Positive_regulation CPOX ARSA 20360429 2266558 *induced* [COX] and specific platelet ADP receptor inhibition attenuate reflex vasodilation , suggesting platelet involvement in reflex vasodilation through the release of vasodilating factors . Positive_regulation CPOX IL1B 10843735 700284 The regulatory effects of interferon (IFN)-gamma and IL-4 on *induced* [COX] , PLA(2)isoforms expression and terminal delayed PGE ( 2 ) generation were examined in three types of human fibroblasts . Positive_regulation CPOX IL1B 11132768 760227 [COX] activity and COX2 expression were significantly *increased* by . Positive_regulation CPOX IL1B 11132768 760229 Annexin I peptide demonstrated no inhibition of constitutive or *induced* [COX] activity . Positive_regulation CPOX IL1B 11407686 825871 Anti-MIF mAb significantly reduced *induced* [COX] activity ( P < 0.05 ) and COX-2 mRNA expression . Positive_regulation CPOX IL1B 12193665 981402 Basal and *stimulated* [COX] activities were inhibited by NS-398 , indicating substantial COX-2 contribution to endothelial prostanoid synthesis in neonatal human brain cortex and cerebellum at rest and when mimicking the inflammatory conditions . Positive_regulation CPOX IL1B 12193665 981403 Acute treatment with the protein tyrosine kinase inhibitor , tyrphostin 25 , inhibited basal and *induced* [COX] activities , suggesting the importance of posttranslational modifications in endothelial COX-2 activation in human brain . Positive_regulation CPOX IL1B 12517972 1039413 however , neither enhanced *induced* [COX] activity . Positive_regulation CPOX IL1B 12881225 1157239 Whether the effects of were mediated through a prostaglandin pathway and whether IL-1beta *induced* the expression of [cyclooxygenase (COX)-2] was also examined . Positive_regulation CPOX IL1B 15067222 1231890 However , the mechanisms underlying *induced* [cyclooxygenase (COX)] expression and PGE ( 2 ) synthesis via activation of p42/p44 and p38 mitogen activated protein kinases ( MAPKs ) in human tracheal smooth muscle cells ( HTSMCs ) are not completely understood . Positive_regulation CPOX IL1B 15111866 1241217 Our data suggest that is inhibitory and that this effect is *mediated* by [cyclooxygenase (COX)-2] . Positive_regulation CPOX IL1B 15479233 1319771 Conversely , whereas dexamethasone and budesonide were highly effective inhibitors of *induced* [cyclooxygenase (COX)/prostaglandin] E synthase (PGES) activity and COX-2 expression , RU486 ( < 1 microm ) was a poor inhibitor , but was able to efficiently antagonize the effects of dexamethasone and budesonide . Positive_regulation CPOX IL1B 15961395 1440750 Here , we investigated the role of c-Jun and activator protein-1 (AP-1) in *induced* dedifferentiation and [cyclooxygenase (COX)-2] expression in primary cultured chondrocytes . Positive_regulation CPOX IL1B 16141635 1454859 DHA and eicosapentaenoic acid slightly enhanced *induced* [cyclooxygenase (COX)-2] , but not COX-1 , expression , whereas arachidonic acid had no effect . Positive_regulation CPOX IL1B 16556676 1562117 By contrast , with the existing known human endometrial cell lines Ishikawa and KLE , HIESC and HIEEC increase their production of PGF2alpha and PGE2 and [cyclooxygenase (COX)-2] protein expression in *response* to . Positive_regulation CPOX IL1B 16645161 1604687 significantly *increased* [cyclooxygenase (COX)-2] and PGE ( 2 ) levels . Positive_regulation CPOX IL1B 17077517 1642376 stimulation *increased* the protein , activity and mRNA expression of [cyclooxygenase (COX)-2] but not COX-1 . Positive_regulation CPOX IL1B 21031267 2338812 The objective of this study is to determine the effects of Ethyl acetate fraction from Cudrania tricuspidata ( EACT ) on the *induced* proliferation of rheumatoid synovial fibroblasts ( RASFs ) and production of matrix metalloproteinases ( MMPs ) , [cyclooxygenase (COX)] and prostaglandin E2 ( PGE2 ) by RASFs . Positive_regulation CPOX IL1B 7527554 280832 The inflammatory cytokine *induces* both [cyclooxygenase (COX)] and nitric oxide synthase (NOS) with increases in the release of prostaglandin ( PG ) and nitric oxide ( NO ) by mesangial cells . Positive_regulation CPOX IL1B 8048967 267167 However , addition of *results* in the induction of [cox] 2 in a time and dose dependent manner ; Positive_regulation CPOX IL1B 8931118 397842 Our findings indicate that *caused* an increase in AA release and [COX] activity and that in the presence of 1,25- ( OH ) 2D3 AA release , but not COX activity , is suppressed . Positive_regulation CPOX IL1B 9179403 434359 5. Pretreatment with the conventional non-steroidal anti-inflammatory drugs ( NSAIDs ) , indomethacin and ibuprofen , and the selective COX-2 inhibitors , NS-398 and nimesulide , completely blocked *induced* PGE2 release and [COX] activity . Positive_regulation CPOX IL1B 9179403 434360 The glucocorticosteroid dexamethasone and protein synthesis inhibitors , cycloheximide and actinomycin D , not only markedly inhibited *stimulated* PGE2 release and [COX] activity but also suppressed IL-1 beta induced COX-2 induction . Positive_regulation CPOX IL1B 9705828 526078 *induced* ICAM-1 , and [COX] activity , while it had no affect on VCAM-1 . Positive_regulation CPOX IL1B 9822711 548935 Repression of *induced* PGE2 release , [COX] activity , and COX-2 protein by actinomycin D was only effective within the first hour following IL-1beta treatment , while dexamethasone was effective when added up to 10 h later , suggesting a functional role for post-transcriptional mechanisms of repression . Positive_regulation CPOX PTGIS 11181435 785187 3. The non-selective [cyclo-oxygenase (COX)] *inhibitor* , indomethacin , a selective COX-2 inhibitor NS-398 or the inhibitor , tranylcypromine ( 10 mg x kg ( -1 ) ) , markedly reduced the inhibitory properties of endothelin-1 , whereas only a combination of both indomethacin , NS-398 or tranylcypromine and L-NAME ( 10 mg x kg ( -1 ) ) were required to abolish the response to bradykinin . Positive_regulation CPOX TLR7 22235849 2591886 Induction of [cyclooxygenase (COX)-2] in human vaginal epithelial cells in *response* to ligands and TNF-a . Positive_regulation CPOX TNF 11179444 784656 The role of p44/42 mitogen activated protein kinase (MAPK) , p38 , and c-Jun NH ( 2 ) -terminal kinase ( JNK ) in *induced* [cyclooxygenase (COX)-2] expression was studied in NCI-H292 epithelial cells . Positive_regulation CPOX TNF 13679315 1185643 When cultured bovine stromal cells were exposed to TNFalpha ( 0.006-0.6 nM ) for 24 h , the production of PGF2alpha and [cyclooxygenase (COX)-2] gene expression were *stimulated* by ( 0.06-0.6 nM , P < 0.05 ) . Positive_regulation CPOX TNF 16960384 1615797 preferentially *promoted* gene expression of [cyclooxygenase (COX)-2] without affecting that of COX-1 . Positive_regulation CPOX TNF 21705614 2465722 Targeting tumor necrosis factor (TNF)-a mediated signal pathways may be a promising strategy for developing chemopreventive agents , because *mediated* [cyclooxygenase (COX)-2] expression plays a key role in inflammation and carcinogenesis . Positive_regulation CPOX TNF 22031851 2547575 Studies in mesangial cells and macrophages were carried out to establish that the in vivo increase in PLA(2) and [COX] were *mediated* by and IL-1ß and that curcumin , by antagonizing the cytokines , could significantly reduce both PLA(2) and COX . Positive_regulation CPOX TNF 22235849 2591885 Induction of [cyclooxygenase (COX)-2] in human vaginal epithelial cells in *response* to TLR ligands and . Positive_regulation CPOX TNF 23706331 2819583 To investigate the action of nuclear factor ( NF ) -?B in adenomyosis and evaluate the potential therapeutic effect of andrographolide on *induced* expression of NF-?B mediated genes [cyclooxygease-2 (COX-2)] , vascular endothelial growth factor ( VEGF ) , and tissue factor ( TF ) in adenomyotic stromal cells . Positive_regulation CPOX TNF 23717114 2714409 Air dried PG leaf extract inhibited *induced* NF-?B transcription activity and NF-?B dependent [cyclooxygenase (COX)-2] and inducible nitric oxide synthase (iNOS) gene expression more efficiently than the steamed extract . Positive_regulation CPOX TNF 25379003 2960126 In addition , REKRG markedly inhibited the mediated *induction* of intercellular adhesion molecule (ICAM)-1 and [cyclooxygenase (COX)-2] expressions in endothelial cells . Positive_regulation CPOX TNF 7582449 333530 Exogenous IL-1 beta , or EGF also *caused* an increase in [COX] activity , while PDGF was ineffective . Positive_regulation CPOX TNF 7582449 333532 These results suggest that ( i ) the induction of [COX] activity and COX-2 protein elicited by LPS in BAEC is *mediated* by with lesser contributions from PDGF , EGF or IL-1 beta ; Positive_regulation CPP EPHB2 18940233 1989099 However , the *roles* of in the morphine paired [conditioned place preference (CPP)] are not clear . Positive_regulation CPP EPHB2 19052216 1999711 Finally , stimulation of central amygdala and CREB phosphorylation by NMDA *enhanced* drug [CPP] after 1 d of withdrawal from morphine , an effect reversed by U0126 . Positive_regulation CPP HES2 9707191 526345 seems to lower ICP more effectively but does not *increase* [CPP] as much as does mannitol . Positive_regulation CPP PLAU 18436315 1908230 Our results suggest that that increased uPA expression with repeated drug exposure produces conditions for enhanced acquisition of cocaine induced CPP , indicating that cocaine induced [CPP] and reinstatement may be *dependent* on active extracellular . Positive_regulation CPSF1 CFI 11713271 880790 In Saccharomyces cerevisiae , in vitro mRNA cleavage and [polyadenylation] *require* the poly ( A ) binding protein , Pab1p , and two multiprotein complexes : ( cleavage factor I ) and CPF ( cleavage and polyadenylation factor ) . Positive_regulation CPSF1 LGALS7B 9174099 433503 Northern blot analysis , PCR amplification , and DNA sequence analysis show that the signal *directs* [polyadenylation] within the body of pre-SUP4 and within the terminator , suggesting that polyadenylation inhibits 5 ' and 3 ' end processing , as well as removal of the pre-tRNA intron . Positive_regulation CPSF2 CFI 11713271 880796 In Saccharomyces cerevisiae , in vitro mRNA cleavage and [polyadenylation] *require* the poly ( A ) binding protein , Pab1p , and two multiprotein complexes : ( cleavage factor I ) and CPF ( cleavage and polyadenylation factor ) . Positive_regulation CPSF2 LGALS7B 9174099 433504 Northern blot analysis , PCR amplification , and DNA sequence analysis show that the signal *directs* [polyadenylation] within the body of pre-SUP4 and within the terminator , suggesting that polyadenylation inhibits 5 ' and 3 ' end processing , as well as removal of the pre-tRNA intron . Positive_regulation CPSF3 CFI 11713271 880802 In Saccharomyces cerevisiae , in vitro mRNA cleavage and [polyadenylation] *require* the poly ( A ) binding protein , Pab1p , and two multiprotein complexes : ( cleavage factor I ) and CPF ( cleavage and polyadenylation factor ) . Positive_regulation CPSF3 LGALS7B 9174099 433505 Northern blot analysis , PCR amplification , and DNA sequence analysis show that the signal *directs* [polyadenylation] within the body of pre-SUP4 and within the terminator , suggesting that polyadenylation inhibits 5 ' and 3 ' end processing , as well as removal of the pre-tRNA intron . Positive_regulation CPSF3 SCARA3 18806823 2021202 The interaction between and CPSF3 *induced* [CPSF3] translocation from the nucleus to the cytoplasm , resulting in inhibition of polyadenylation both in vitro and in vivo . Positive_regulation CPT1A PGC 16271724 1490148 We have shown that this sequence is fundamental for fatty acids or induced transcriptional *activation* of the [CPT1A] gene . Positive_regulation CPT1A PGC 21486805 2417690 Over-expression of also *increased* [Cpt-1ß] , Cox4 and Vegf mRNA by 6.2- , 2.0- and 2.0-fold , respectively . Positive_regulation CPT1A PGC 21486805 2417693 Furthermore , our results suggest a novel role of STARS in the co-ordination of *induced* upregulation of the fat oxidative gene , [CPT-1ß] . Positive_regulation CPT1A PGC 23602251 2774496 Overexpression of wild-type PGC-1a , but not mutant , also *caused* a significant increase in hepatocyte expression of [carnitine palmitoyl transferase 1a] , a rate determining enzyme that transfers long-chain fatty acids into mitochondria for oxidation . Positive_regulation CR1 TNF 2961377 84136 Recombinant IL-1 had no effect on receptor expression , but recombinant *increased* [CR1] and CR3 expression with kinetics similar to the supernatants . Positive_regulation CR1 TNF 9950773 595734 Lipopolysaccharide or also significantly *increased* HUVEC [CR1] protein expression . Positive_regulation CRABP2 NGFR 8396608 230312 In contrast to these data , both and all-trans retinoic acid *caused* marked and significant ( p < 0.05 ) elevation of [cellular retinoic acid binding protein-II] ( CRABP-II ) messenger ribonucleic acid steady-state levels as judged by quantitative RNA blot analysis . Positive_regulation CRAT EPHB2 11861527 917307 We conclude that and JNK are *involved* in basal and GnRH-A stimulation of [LHbeta-CAT] activity . Positive_regulation CRAT FUT4 8978306 408989 Subsequent cross linking of *increased* [CAT] activity . Positive_regulation CRAT IL1B 11052811 743466 The *stimulated* the collagenase-CAT and [AP-1-CAT] activities in a dose dependent manner with respect to the amount of DNA used in transfections . Positive_regulation CRAT KLF9 11751593 898574 By contrast , VP16/PR-B and *had* no effect on basal [CAT] activity . Positive_regulation CRAT KLF9 11751593 898578 In transient cotransfection assays using the CAT reporter gene driven by the mouse mammary tumor virus-long terminal repeat promoter , which is responsive to ligand bound PR but not BTEB1 , *increased* PR-B mediated [CAT] activity in a progesterone dependent manner , consistent with a BTEB1/PR-dimer complex occurring independent of BTEB1 binding to DNA . Positive_regulation CRAT LBP 24146519 2859320 Thus , can *increase* SOD , [CAT] and GSH-px levels in blood and reduce MDA level . Positive_regulation CRAT RARB 15026551 1222790 expression markedly *stimulated* [CAT] activity ( up to about 4-fold ) after the addition of ACR . Positive_regulation CRAT TNF 10615072 656342 The pharmacologic profile of *induced* [CAT] activity was identical to TNF induced DNA binding by AP-1 . Positive_regulation CRAT TNF 11340302 812462 *stimulated* [CAT] expression , which was significantly inhibited by transfection of NFkappaB , but not by scrambled decoy ODN . Positive_regulation CRAT TNF 12606638 1079742 In contrast , Ad.N17Rac1 inhibited *induced* NF-kappaB-driven HIV ( kappaB ) ( 4 ) [-CAT] and p288VCAM-Luc promoter activity , suggesting that N17Rac1 inhibits TNF-alpha induced VCAM-1 , E-selectin , and ICAM-1 through suppressing NF-kappaB mediated transactivation . Positive_regulation CRAT TNF 16754199 1571441 Moreover , inhibition of the ceramide biosynthesis with fumonisin B , which inhibits ceramide synthase , completely restored insulin induced GLUT4 mRNA and protein accumulation as well as [GLUT4-CAT] transactivation in the *presence* of . Positive_regulation CRAT TNF 2200614 140408 In this model system , endotoxin lipopolysaccharide (LPS) and are able to independently *stimulate* expression of [LTR-CAT] . Positive_regulation CRAT TNF 7884319 298989 It was found that LPS or IL-6 alone *induced* moderate levels of [CAT] expression , whereas IFN-gamma or had no significant effect . Positive_regulation CREB1 ADRB2 15024018 1243887 stimulation *increased* [CREB] phosphorylation , OCA-B expression , and OCA-B binding to the 3'-IgH enhancer in a protein kinase A-dependent manner , an effect lost when beta2-adrenergic receptor-deficient B cells were used . Positive_regulation CREB1 ADRB2 23436577 2771359 activation in Treg cells *leads* to increased intracellular cAMP levels and to protein kinase A (PKA) dependent [CREB] phosphorylation . Positive_regulation CREB1 CAPN8 18982459 1989711 After outlining the major features of different cell death mechanisms in general , we then compare them with results obtained in retinal degeneration models , where photoreceptor cell death appears to be governed by , among other things , changes in cyclic nucleotide metabolism , downregulation of the transcription factor [CREB] , and excessive *activation* of and PARP . Positive_regulation CREB1 CAPN8 23799606 2807941 Our results clearly showed that ICV injection of NPD1 at 2 h after reperfusion improves the neurological status of middle cerebral artery occlusion ( MCAO ) rats through the inhibition of TRPC6 proteolysis and the subsequent *activation* of [CREB] via the Ras/MEK/ERK pathway . Positive_regulation CREB1 CAPN8 24193141 2885971 In conclusion , the results clearly demonstrated that intracerebroventricular injection of EGCG immediately following ischemia , inhibits ERS and improves the neurological status of rats that have undergone middle cerebral artery occlusion via the inhibition of TRPC6 proteolysis and the subsequent *activation* of [CREB] via the MEK/extracellular signal regulated kinases ( ERK ) pathway . Positive_regulation CREB1 CCND1 12391146 1001671 We describe an alternative mechanism for [CREB-driven] *induction* that involves the ubiquitous POU domain protein Oct-1 . Positive_regulation CREB1 CCND1 16522741 1531507 Taken together , EX-induced expression is largely dependent on the cAMP/PKA signaling pathway , and EX *increases* the level of phosphorylated [CREB] and more potently trans-activates cyclin D1 gene through binding of the CREB to the putative CRE site , implicating a potential mechanism underlying beta-cell proliferation by EX . Positive_regulation CREB1 EPHB2 11371570 834843 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and and *activation* of [cAMP-responsive element binding protein] ( CREB ) , NF-kappaB , and E2F ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation CREB1 EPHB2 11682632 874323 activation by the PKA pathway was not *required* for [CREB/ATF-1] phosphorylation but rather was necessary for CREB dependent up-regulation of C/EBPs expression . Positive_regulation CREB1 EPHB2 11682632 874327 Our findings suggest that activation is *required* for [CREB] transcriptional activity , possibly by recruitment of a coactivator . Positive_regulation CREB1 EPHB2 12008033 940708 We compared the BCR *induced* intracellular [ Ca2+ ] transient , protein tyrosine phosphorylation and phosphorylation , furthermore , the activation of Elk-1 and [CREB] transcription factors . Positive_regulation CREB1 EPHB2 12200150 982786 [CREB] DNA binding activation by a 50-Hz magnetic field in HL60 cells is *dependent* on extra- and intracellular Ca ( 2+ ) but not PKA , PKC , , or p38 MAPK . Positive_regulation CREB1 EPHB2 12529240 1084525 Both early gene activation and [CREB] phosphorylation were *inhibited* by phosphorylation blockade . Positive_regulation CREB1 EPHB2 15265911 1275543 We also show that [CREB] is activated downstream of the pre-TCR complex , and that the induction of CREB activity is *regulated* by protein kinase C alpha- and mediated signals . Positive_regulation CREB1 EPHB2 15383527 1334757 DNA precipitation assays and DNA decoy experiments indicated that dependent *activation* of [CREB] binding to a CRE/AP-1 like element ( designated `` CRE2 '' ) at the position of -413 largely contributed to the transcriptional effects of FSS . Positive_regulation CREB1 EPHB2 15389611 1300399 Second , while phosphorylation of and RSK are modulated by visual experience , phosphorylation of [CREB] at serines 133 , 142 , or 143 is *detected* constitutively and is unaffected by experience . Positive_regulation CREB1 EPHB2 15709700 1351762 We present novel results from our laboratory showing mediated [CREB] *activation* by hydrogen peroxide . Positive_regulation CREB1 EPHB2 16151051 1499395 In this study , we tested the hypotheses that oxidants induce Ca2+ mediated phosphorylation of and CREB , and that [CREB] is *required* for oxidant induced proliferation and apoptosis . Positive_regulation CREB1 EPHB2 16164634 1456331 Inhibition of also *inhibited* [CREB] activation . Positive_regulation CREB1 EPHB2 16168389 1461559 IGF-1 induced [CREB] phosphorylation was *mediated* by , PI3-K , p38-MAPK , as well as Ca ( 2+ ) /calmodulin kinase and calcineurin . Positive_regulation CREB1 EPHB2 16516913 1549264 The p38MAPK inhibitor , SB203580 , and the kinase inhibitor , PD98059 each partially *inhibited* exogenous AII conferred [CREB] activation confirming that p38MAPK and ERK1/2 mediate CREB phosphorylation in this system . Positive_regulation CREB1 EPHB2 16854387 1600388 Short chain fatty acids induce TH gene expression via *dependent* phosphorylation of [CREB] protein . Positive_regulation CREB1 EPHB2 16923128 1603104 Taken together , NGF induced PC12 cell differentiation requires pathway *mediated* activation of [CREB] . Positive_regulation CREB1 EPHB2 17074386 1708960 We propose that ryanodine receptor stimulation by activity generated redox species produces calcium release signals that may contribute significantly to hippocampal synaptic plasticity , including plasticity that requires long lasting *dependent* [CREB] phosphorylation . Positive_regulation CREB1 EPHB2 17082637 1643367 inhibition not only *blocked* phosphorylation of Elk1 , [CREB] , and ATF1 , which constitutively bind to the FRA-1 promoter , but also suppressed the recruitment of c-Jun to the promoter . Positive_regulation CREB1 EPHB2 17582742 1774450 Moreover , both baclofen and CGP7930 induce *dependent* [CREB] phosphorylation . Positive_regulation CREB1 EPHB2 18205034 1863805 Activation of PKA , PKC , and p38 MAPK is *involved* in preconditioning induced [CREB] phosphorylation . Positive_regulation CREB1 EPHB2 18837011 1988208 *mediates* activity dependent neuronal complexity via sustained activity and [CREB] mediated signaling . Positive_regulation CREB1 EPHB2 19385062 2069348 The exchange protein directly activated by cAMP ( Epac ) activator , 8CPT-2Me-cAMP , promoted the Akt/eNOS/NO pathway and phosphorylation , but did not *induce* [CREB] phosphorylation and VEGF expression . Positive_regulation CREB1 EPHB2 19508427 2108607 The sustained activation of but a transient *activation* of [CREB] together suggest that exposure to homocysteine initiates a feedback loop that shuts off CREB signaling without affecting ERK phosphorylation and thereby facilitates homocysteine mediated neurotoxicity . Positive_regulation CREB1 EPHB2 21798274 2490267 In addition , P2Y(13) and P2X7 receptor agonists were also able to phosphorylate and activate the *dependent* target [CREB] , which could be involved in their neuroprotective effect . Positive_regulation CREB1 EPHB2 22916239 2657611 These results show that luteolin induces the up-regulation of miR-132 , which serves as an important regulator for neurotrophic actions , mainly acting through the activation of cAMP/PKA- and *dependent* [CREB] signaling pathways in PC12 cells . Positive_regulation CREB1 EPHB2 24048848 2842884 In vitro , estrogen receptor a (ERa) signaling through metabotropic glutamate receptor 1a ( mGluR1a ) leads to *dependent* [CREB] phosphorylation ( Boulware et al. , 2005 ) , suggesting that interactions between ERs and mGluR1a may be vital to the memory enhancing effects of E2 . Positive_regulation CREB1 EPHB2 9528766 496064 Inhibition of either the or the p38/MAPKAP kinase 2 pathway only partially *blocked* NGF induced [CREB] Ser-133 phosphorylation , suggesting that either pathway alone is sufficient for coupling the NGF signal to CREB activation . Positive_regulation CREB1 EPHB2 9808472 545203 The sequential activation of and Rsk2 by Ca2+ *leads* to the phosphorylation and transactivation of [CREB] . Positive_regulation CREB1 EPHB2 9808472 545235 Furthermore , the full expression of the late phase of long-term potentiation ( L-LTP ) and L-LTP associated CRE mediated transcription requires ERK activation , suggesting that the *activation* of [CREB] by plays a critical role in the formation of long lasting neuronal plasticity . Positive_regulation CREB1 GLP1R 23188390 2723923 In insulinoma cell lines , the expression of exogenous *restored* cAMP production and the phosphorylation of [CREB] . Positive_regulation CREB1 IL1B 10397405 627819 This was demonstrated by showing that coexpression of [CREB] stimulated native but not CRE mutant promoter and that and PMA *induced* less activity with the mutant promoter as compared to the native promoter . Positive_regulation CREB1 IL1B 10965886 728051 The transcription factor [CREB] , a potential substrate of both protein kinase A (PKA) and RSK-1 , is phosphorylated in *response* to and cAMP in HepG2 cells . Positive_regulation CREB1 IL1B 18789903 1976132 Mutational analysis and supershift assays indicated that *stimulated* c-jun and [CREB1] binding to the essential AP-1/CRE site of the MIP-1beta promoter . Positive_regulation CREB1 MAP2K6 10406459 629444 We further demonstrate that although inhibition of *represses* forskolin induced [CREB] activation , forskolin by itself failed to activate ERK1/2 and Elk-1 mediated transcription . Positive_regulation CREB1 MAP2K6 11591753 869560 Inhibition of activity also *inhibited* IL3 induced [CREB] phosphorylation . Positive_regulation CREB1 MAP2K6 11885780 894092 The activations of [CREB] and NF-kappaB were *blocked* by inhibitors of either p38 ( SB-203580 ) or ( PD-098059 ) , suggesting that they were events downstream of MAK kinase . Positive_regulation CREB1 MAP2K6 16061232 1442109 The activation of JAK2 or apparently *mediated* the magnolol induced phosphorylation of [CREB] and the upregulation of StAR . Positive_regulation CREB1 MAP2K6 16176063 1457700 The LPA induced phosphorylation of ERK 1/2 and [CREB] was *blocked* by inhibition of PI3K , PKC and , but that of Akt was only inhibited by wortmannin , the PI3K inhibitor . Positive_regulation CREB1 MAP2K6 18656513 1972841 was *required* for phosphorylation of ERK and [CREB] , but not Akt , whereas G ( 0 ) /G ( i ) -proteins were necessary for phosphorylation of Akt and CREB , and cGMP was necessary for Akt phosphorylation . Positive_regulation CREB1 MAP2K6 21295555 2403482 The riluzole induced [CREB] phosphorylation was completely *blocked* by a mitogen activated protein kinase kinase ( ) inhibitor ( U0126 ) . Positive_regulation CREB1 MAP2K6 21448293 2412579 Here we describe a novel neuronal signaling pathway whereby CRF leads to a rapid Gß?- and *dependent* increase in [CREB] phosphorylation . Positive_regulation CREB1 MAP2K6 21977288 2362332 The inhibition of PKA , PKC , , p38-MAPK or PI3-kinase partially *reduced* the strain induced [CREB] phosphorylation . Positive_regulation CREB1 MAP2K6 22932066 2785938 inhibitors -- PD98059 and U0126 -- *blocked* the effect of bFGF on phosphorylated [CREB] while a p38-MAPK inhibitor -- SB203580 -- blocked the effect of IL1ß on phosphorylated CREB . Positive_regulation CREB1 MAP2K6 24185007 2875612 Preliminary analysis of biopsies from BRAF ( V600E ) melanoma patients revealed that phosphorylated ( active ) [CREB] was *suppressed* by inhibition but restored in relapsing tumours . Positive_regulation CREB1 PGC 11557984 861453 Fasting hyperglycaemia is strongly correlated with type II diabetes , so our results suggest that the *activation* of by [CREB] in liver contributes importantly to the pathogenesis of this disease . Positive_regulation CREB1 PGC 22767158 2676337 hesperetin activates PI-3 K , PKA , PKC , ERK1 and [CREB] , and it *induces* PI-3 K , PKA , and seladin-1 via both ER and TrkA ; Positive_regulation CREB1 PPBP 19224810 2039884 The *induced* increase in [CREB] phosphorylation was blocked by H89 ( 0.5 +/- 0.07 ) but not U0126 , KN62 , or LY294002 . Positive_regulation CREB1 RCAN1 21890628 2496517 Furthermore , we found that the increased *activation* of [CREB] signaling by depended on the ability of RCAN1 to inhibit calcineurin activity . Positive_regulation CREB1 RCAN1 21890628 2496523 Our data provide the first evidence that *acts* as an important regulatory component in the control of [CREB] signaling . Positive_regulation CREB1 RCAN1 23150431 2751919 Furthermore , *induced* the expression of the [CREB] target gene , Bcl-2 . Positive_regulation CREB1 RGS2 22057271 2516932 Forskolin stimulated RGS2 mRNA up-regulation is inhibited by CREB sequestration or specific disruption of the promoter interaction , and Ang II-induced [CREB] phosphorylation and nuclear localization are *blocked* by iPLA(2)ß pharmacologic inhibition or genetic ablation . Positive_regulation CREB1 SPHK1 16313513 1486941 Moreover , [CREB] phosphorylation in response to NT-3 *involves* , the enzyme that synthesizes S1P . Positive_regulation CREB1 TF 10067852 594004 These results suggest that optimal activation of the mouse promoter by FSH *requires* both [CREB] binding to the CRE-like PRII region and bHLH binding to the E-box . Positive_regulation CREB1 TLR7 21398611 2411892 Mal mediates induced *activation* of [CREB] and expression of IL-10 . Positive_regulation CREB1 TNF 10211885 607712 AP-2 and [CREB] were not *induced* by . Positive_regulation CREB1 TNF 10383461 624619 Furthermore , overexpression of CREB but not mutated CREB by retroviral mediated gene transfer reversed hypoxia elicited induction of TNF-alpha defining a causal relationship between hypoxia elicited [CREB] reduction and *induction* . Positive_regulation CREB1 TNF 10585438 571392 Stimulation of Sertoli cells with , an NF-kappaB activating cytokine produced by round spermatids located adjacent to Sertoli cells , *stimulated* the elimination of IkappaB , the translocation of additional NF-kappaB to the nucleus , and increased NF-kappaB binding to [CREB] promoter kappaB enhancer elements . Positive_regulation CREB1 TNF 10585438 571397 also *stimulated* transcription from the [CREB] promoter . Positive_regulation CREB1 TNF 10903915 713435 We demonstrated here that intracellular localization of these redox molecules differ from each other and that the redox molecules differentially regulate NF-kappaB , AP-1 , and [CREB] activation *induced* by , PMA , and forskolin and by expression of signaling intermediate kinases , NIK , MEKK , and PKA in HEK293 cells . Positive_regulation CREB1 TNF 11085968 750829 Electrophoretic mobility shift assay demonstrated that *enhanced* DNA binding of osteoblast specific factor ( Osf2 ) , AP1 , and [CREB] , transcription factors that are important for osteoblastic differentiation . Positive_regulation CREB1 TNF 14761884 1207120 Dominant negative CREB , an antagonist antibody directed against the type 1 TNF receptor , or pharmacological inhibition of p38 MAPK signaling blocked *induced* [CREB] activation as determined by phosphorylation and gene reporter assays . Positive_regulation CREB1 TNF 14761884 1207153 These observations show that [CREB] is *activated* by signaling through a p38MAPK/MSK1 signaling pathway . Positive_regulation CREB1 TNF 15242860 1289512 *induced* [CREB] phosphorylation with a peak at 15 minutes of stimulation . Positive_regulation CREB1 TNF 15242860 1289528 Pharmacological inhibition of p38 mitogen activated protein kinase ( p38-MAPK ) inhibited *induced* [CREB] phosphorylation . Positive_regulation CREB1 TNF 15242860 1289557 Adenovirus mediated overexpression of dominant negative form of CREB suppressed *induced* [CREB] phosphorylation and c-fos mRNA expression . Positive_regulation CREB1 TNF 15753227 1380085 and glucose *induced* a dose- and time dependent activation of the p38 MAP kinase , the downstream kinase mitogen- and stress activated kinase 1 , and the transcription factor [cAMP-responsive element binding protein] ( CREB ) , in EPCs . Positive_regulation CREB1 TNF 16715652 1565095 *induced* phosphorylation of [CREB] with a peak at 15 min of stimulation in a dose dependent manner in bovine aortic ECs . Positive_regulation CREB1 TNF 16715652 1565111 Pharmacological inhibition of p38 mitogen activated protein kinase ( p38-MAPK ) inhibited *induced* [CREB] phosphorylation . Positive_regulation CREB1 TNF 17082637 1643374 Our findings collectively indicate that ERK signaling plays key roles in both Elk1 , [CREB] , and ATF-1 activation and the subsequent recruitment of c-Jun to the FRA-1 promoter in *response* to in pulmonary epithelial cells . Positive_regulation CREB1 TNF 19339243 2074336 *induced* [CREB] phosphorylation in vitro and DNA binding and reporter gene activities in vivo . Positive_regulation CREB1 TNF 19339243 2074343 *induced* [CREB] activation via ERK1/2 , and inhibition of ERK1/2 and CREB blunted TNF-alpha mediated WISP1 induction . Positive_regulation CREB1 TNF 24038085 2851646 Neutrophil stimulation with LPS or *led* to the phosphorylation , DNA binding activity , and chemokine promoter association of [CREB1] and activating transcription factor-1 . Positive_regulation CREB1 TNFSF10 12807432 1101897 Moreover , *increased* CREB phosphorylation and [phospho-CREB] DNA binding activity in a phosphatidylinositol 3-kinase (PI 3K)/Akt dependent manner . Positive_regulation CREB3 ADRB2 15024018 1243888 stimulation *increased* [CREB] phosphorylation , OCA-B expression , and OCA-B binding to the 3'-IgH enhancer in a protein kinase A-dependent manner , an effect lost when beta2-adrenergic receptor-deficient B cells were used . Positive_regulation CREB3 ADRB2 23436577 2771366 activation in Treg cells *leads* to increased intracellular cAMP levels and to protein kinase A (PKA) dependent [CREB] phosphorylation . Positive_regulation CREB3 CAPN8 18982459 1989738 After outlining the major features of different cell death mechanisms in general , we then compare them with results obtained in retinal degeneration models , where photoreceptor cell death appears to be governed by , among other things , changes in cyclic nucleotide metabolism , downregulation of the transcription factor [CREB] , and excessive *activation* of and PARP . Positive_regulation CREB3 CAPN8 23799606 2807956 Our results clearly showed that ICV injection of NPD1 at 2 h after reperfusion improves the neurological status of middle cerebral artery occlusion ( MCAO ) rats through the inhibition of TRPC6 proteolysis and the subsequent *activation* of [CREB] via the Ras/MEK/ERK pathway . Positive_regulation CREB3 CAPN8 24193141 2885986 In conclusion , the results clearly demonstrated that intracerebroventricular injection of EGCG immediately following ischemia , inhibits ERS and improves the neurological status of rats that have undergone middle cerebral artery occlusion via the inhibition of TRPC6 proteolysis and the subsequent *activation* of [CREB] via the MEK/extracellular signal regulated kinases ( ERK ) pathway . Positive_regulation CREB3 CCND1 12391146 1001672 We describe an alternative mechanism for [CREB-driven] *induction* that involves the ubiquitous POU domain protein Oct-1 . Positive_regulation CREB3 CCND1 16522741 1531508 Taken together , EX-induced expression is largely dependent on the cAMP/PKA signaling pathway , and EX *increases* the level of phosphorylated [CREB] and more potently trans-activates cyclin D1 gene through binding of the CREB to the putative CRE site , implicating a potential mechanism underlying beta-cell proliferation by EX . Positive_regulation CREB3 EPHB2 11371570 834844 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and and *activation* of [cAMP-responsive element binding protein] ( CREB ) , NF-kappaB , and E2F ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation CREB3 EPHB2 11682632 874324 activation by the PKA pathway was not *required* for [CREB/ATF-1] phosphorylation but rather was necessary for CREB dependent up-regulation of C/EBPs expression . Positive_regulation CREB3 EPHB2 11682632 874328 Our findings suggest that activation is *required* for [CREB] transcriptional activity , possibly by recruitment of a coactivator . Positive_regulation CREB3 EPHB2 12008033 940709 We compared the BCR *induced* intracellular [ Ca2+ ] transient , protein tyrosine phosphorylation and phosphorylation , furthermore , the activation of Elk-1 and [CREB] transcription factors . Positive_regulation CREB3 EPHB2 12200150 982806 [CREB] DNA binding activation by a 50-Hz magnetic field in HL60 cells is *dependent* on extra- and intracellular Ca ( 2+ ) but not PKA , PKC , , or p38 MAPK . Positive_regulation CREB3 EPHB2 12529240 1084526 Both early gene activation and [CREB] phosphorylation were *inhibited* by phosphorylation blockade . Positive_regulation CREB3 EPHB2 15265911 1275558 We also show that [CREB] is activated downstream of the pre-TCR complex , and that the induction of CREB activity is *regulated* by protein kinase C alpha- and mediated signals . Positive_regulation CREB3 EPHB2 15383527 1334758 DNA precipitation assays and DNA decoy experiments indicated that dependent *activation* of [CREB] binding to a CRE/AP-1 like element ( designated `` CRE2 '' ) at the position of -413 largely contributed to the transcriptional effects of FSS . Positive_regulation CREB3 EPHB2 15389611 1300400 Second , while phosphorylation of and RSK are modulated by visual experience , phosphorylation of [CREB] at serines 133 , 142 , or 143 is *detected* constitutively and is unaffected by experience . Positive_regulation CREB3 EPHB2 15709700 1351763 We present novel results from our laboratory showing mediated [CREB] *activation* by hydrogen peroxide . Positive_regulation CREB3 EPHB2 16151051 1499397 In this study , we tested the hypotheses that oxidants induce Ca2+ mediated phosphorylation of and CREB , and that [CREB] is *required* for oxidant induced proliferation and apoptosis . Positive_regulation CREB3 EPHB2 16164634 1456332 Inhibition of also *inhibited* [CREB] activation . Positive_regulation CREB3 EPHB2 16168389 1461578 IGF-1 induced [CREB] phosphorylation was *mediated* by , PI3-K , p38-MAPK , as well as Ca ( 2+ ) /calmodulin kinase and calcineurin . Positive_regulation CREB3 EPHB2 16516913 1549279 The p38MAPK inhibitor , SB203580 , and the kinase inhibitor , PD98059 each partially *inhibited* exogenous AII conferred [CREB] activation confirming that p38MAPK and ERK1/2 mediate CREB phosphorylation in this system . Positive_regulation CREB3 EPHB2 16854387 1600389 Short chain fatty acids induce TH gene expression via *dependent* phosphorylation of [CREB] protein . Positive_regulation CREB3 EPHB2 16923128 1603106 Taken together , NGF induced PC12 cell differentiation requires pathway *mediated* activation of [CREB] . Positive_regulation CREB3 EPHB2 17074386 1708961 We propose that ryanodine receptor stimulation by activity generated redox species produces calcium release signals that may contribute significantly to hippocampal synaptic plasticity , including plasticity that requires long lasting *dependent* [CREB] phosphorylation . Positive_regulation CREB3 EPHB2 17082637 1643368 inhibition not only *blocked* phosphorylation of Elk1 , [CREB] , and ATF1 , which constitutively bind to the FRA-1 promoter , but also suppressed the recruitment of c-Jun to the promoter . Positive_regulation CREB3 EPHB2 17582742 1774451 Moreover , both baclofen and CGP7930 induce *dependent* [CREB] phosphorylation . Positive_regulation CREB3 EPHB2 18205034 1863825 Activation of PKA , PKC , and p38 MAPK is *involved* in preconditioning induced [CREB] phosphorylation . Positive_regulation CREB3 EPHB2 18837011 1988209 *mediates* activity dependent neuronal complexity via sustained activity and [CREB] mediated signaling . Positive_regulation CREB3 EPHB2 19385062 2069349 The exchange protein directly activated by cAMP ( Epac ) activator , 8CPT-2Me-cAMP , promoted the Akt/eNOS/NO pathway and phosphorylation , but did not *induce* [CREB] phosphorylation and VEGF expression . Positive_regulation CREB3 EPHB2 19508427 2108608 The sustained activation of but a transient *activation* of [CREB] together suggest that exposure to homocysteine initiates a feedback loop that shuts off CREB signaling without affecting ERK phosphorylation and thereby facilitates homocysteine mediated neurotoxicity . Positive_regulation CREB3 EPHB2 21798274 2490268 In addition , P2Y(13) and P2X7 receptor agonists were also able to phosphorylate and activate the *dependent* target [CREB] , which could be involved in their neuroprotective effect . Positive_regulation CREB3 EPHB2 22916239 2657612 These results show that luteolin induces the up-regulation of miR-132 , which serves as an important regulator for neurotrophic actions , mainly acting through the activation of cAMP/PKA- and *dependent* [CREB] signaling pathways in PC12 cells . Positive_regulation CREB3 EPHB2 24048848 2842886 In vitro , estrogen receptor a (ERa) signaling through metabotropic glutamate receptor 1a ( mGluR1a ) leads to *dependent* [CREB] phosphorylation ( Boulware et al. , 2005 ) , suggesting that interactions between ERs and mGluR1a may be vital to the memory enhancing effects of E2 . Positive_regulation CREB3 EPHB2 9528766 496066 Inhibition of either the or the p38/MAPKAP kinase 2 pathway only partially *blocked* NGF induced [CREB] Ser-133 phosphorylation , suggesting that either pathway alone is sufficient for coupling the NGF signal to CREB activation . Positive_regulation CREB3 EPHB2 9808472 545206 The sequential activation of and Rsk2 by Ca2+ *leads* to the phosphorylation and transactivation of [CREB] . Positive_regulation CREB3 EPHB2 9808472 545236 Furthermore , the full expression of the late phase of long-term potentiation ( L-LTP ) and L-LTP associated CRE mediated transcription requires ERK activation , suggesting that the *activation* of [CREB] by plays a critical role in the formation of long lasting neuronal plasticity . Positive_regulation CREB3 GLP1R 23188390 2723924 In insulinoma cell lines , the expression of exogenous *restored* cAMP production and the phosphorylation of [CREB] . Positive_regulation CREB3 IL1B 10397405 627820 This was demonstrated by showing that coexpression of [CREB] stimulated native but not CRE mutant promoter and that and PMA *induced* less activity with the mutant promoter as compared to the native promoter . Positive_regulation CREB3 IL1B 10965886 728052 The transcription factor [CREB] , a potential substrate of both protein kinase A (PKA) and RSK-1 , is phosphorylated in *response* to and cAMP in HepG2 cells . Positive_regulation CREB3 MAP2K6 10406459 629451 We further demonstrate that although inhibition of *represses* forskolin induced [CREB] activation , forskolin by itself failed to activate ERK1/2 and Elk-1 mediated transcription . Positive_regulation CREB3 MAP2K6 11591753 869568 Inhibition of activity also *inhibited* IL3 induced [CREB] phosphorylation . Positive_regulation CREB3 MAP2K6 11885780 894100 The activations of [CREB] and NF-kappaB were *blocked* by inhibitors of either p38 ( SB-203580 ) or ( PD-098059 ) , suggesting that they were events downstream of MAK kinase . Positive_regulation CREB3 MAP2K6 16061232 1442117 The activation of JAK2 or apparently *mediated* the magnolol induced phosphorylation of [CREB] and the upregulation of StAR . Positive_regulation CREB3 MAP2K6 16176063 1457710 The LPA induced phosphorylation of ERK 1/2 and [CREB] was *blocked* by inhibition of PI3K , PKC and , but that of Akt was only inhibited by wortmannin , the PI3K inhibitor . Positive_regulation CREB3 MAP2K6 18656513 1972848 was *required* for phosphorylation of ERK and [CREB] , but not Akt , whereas G ( 0 ) /G ( i ) -proteins were necessary for phosphorylation of Akt and CREB , and cGMP was necessary for Akt phosphorylation . Positive_regulation CREB3 MAP2K6 21295555 2403489 The riluzole induced [CREB] phosphorylation was completely *blocked* by a ( MEK ) inhibitor ( U0126 ) . Positive_regulation CREB3 MAP2K6 21448293 2412587 Here we describe a novel neuronal signaling pathway whereby CRF leads to a rapid Gß?- and *dependent* increase in [CREB] phosphorylation . Positive_regulation CREB3 MAP2K6 21977288 2362360 The inhibition of PKA , PKC , , p38-MAPK or PI3-kinase partially *reduced* the strain induced [CREB] phosphorylation . Positive_regulation CREB3 MAP2K6 22932066 2785945 inhibitors -- PD98059 and U0126 -- *blocked* the effect of bFGF on phosphorylated [CREB] while a p38-MAPK inhibitor -- SB203580 -- blocked the effect of IL1ß on phosphorylated CREB . Positive_regulation CREB3 MAP2K6 24185007 2875619 Preliminary analysis of biopsies from BRAF ( V600E ) melanoma patients revealed that phosphorylated ( active ) [CREB] was *suppressed* by inhibition but restored in relapsing tumours . Positive_regulation CREB3 PGC 11557984 861454 Fasting hyperglycaemia is strongly correlated with type II diabetes , so our results suggest that the *activation* of by [CREB] in liver contributes importantly to the pathogenesis of this disease . Positive_regulation CREB3 PGC 22767158 2676345 hesperetin activates PI-3 K , PKA , PKC , ERK1 and [CREB] , and it *induces* PI-3 K , PKA , and seladin-1 via both ER and TrkA ; Positive_regulation CREB3 PPBP 19224810 2039885 The *induced* increase in [CREB] phosphorylation was blocked by H89 ( 0.5 +/- 0.07 ) but not U0126 , KN62 , or LY294002 . Positive_regulation CREB3 RCAN1 21890628 2496518 Furthermore , we found that the increased *activation* of [CREB] signaling by depended on the ability of RCAN1 to inhibit calcineurin activity . Positive_regulation CREB3 RCAN1 21890628 2496524 Our data provide the first evidence that *acts* as an important regulatory component in the control of [CREB] signaling . Positive_regulation CREB3 RCAN1 23150431 2751921 Furthermore , *induced* the expression of the [CREB] target gene , Bcl-2 . Positive_regulation CREB3 RGS2 22057271 2516934 Forskolin stimulated RGS2 mRNA up-regulation is inhibited by CREB sequestration or specific disruption of the promoter interaction , and Ang II-induced [CREB] phosphorylation and nuclear localization are *blocked* by iPLA(2)ß pharmacologic inhibition or genetic ablation . Positive_regulation CREB3 SPHK1 16313513 1486943 Moreover , [CREB] phosphorylation in response to NT-3 *involves* , the enzyme that synthesizes S1P . Positive_regulation CREB3 TF 10067852 594005 These results suggest that optimal activation of the mouse promoter by FSH *requires* both [CREB] binding to the CRE-like PRII region and bHLH binding to the E-box . Positive_regulation CREB3 TLR7 21398611 2411902 Mal mediates induced *activation* of [CREB] and expression of IL-10 . Positive_regulation CREB3 TNF 10211885 607713 AP-2 and [CREB] were not *induced* by . Positive_regulation CREB3 TNF 10383461 624620 Furthermore , overexpression of CREB but not mutated CREB by retroviral mediated gene transfer reversed hypoxia elicited induction of TNF-alpha defining a causal relationship between hypoxia elicited [CREB] reduction and *induction* . Positive_regulation CREB3 TNF 10585438 571393 Stimulation of Sertoli cells with , an NF-kappaB activating cytokine produced by round spermatids located adjacent to Sertoli cells , *stimulated* the elimination of IkappaB , the translocation of additional NF-kappaB to the nucleus , and increased NF-kappaB binding to [CREB] promoter kappaB enhancer elements . Positive_regulation CREB3 TNF 10585438 571398 also *stimulated* transcription from the [CREB] promoter . Positive_regulation CREB3 TNF 10903915 713436 We demonstrated here that intracellular localization of these redox molecules differ from each other and that the redox molecules differentially regulate NF-kappaB , AP-1 , and [CREB] activation *induced* by , PMA , and forskolin and by expression of signaling intermediate kinases , NIK , MEKK , and PKA in HEK293 cells . Positive_regulation CREB3 TNF 11085968 750830 Electrophoretic mobility shift assay demonstrated that *enhanced* DNA binding of osteoblast specific factor ( Osf2 ) , AP1 , and [CREB] , transcription factors that are important for osteoblastic differentiation . Positive_regulation CREB3 TNF 14761884 1207135 Dominant negative CREB , an antagonist antibody directed against the type 1 TNF receptor , or pharmacological inhibition of p38 MAPK signaling blocked induced [CREB] *activation* as determined by phosphorylation and gene reporter assays . Positive_regulation CREB3 TNF 14761884 1207155 These observations show that [CREB] is *activated* by signaling through a p38MAPK/MSK1 signaling pathway . Positive_regulation CREB3 TNF 15242860 1289513 *induced* [CREB] phosphorylation with a peak at 15 minutes of stimulation . Positive_regulation CREB3 TNF 15242860 1289542 Pharmacological inhibition of p38 mitogen activated protein kinase ( p38-MAPK ) inhibited *induced* [CREB] phosphorylation . Positive_regulation CREB3 TNF 15242860 1289558 Adenovirus mediated overexpression of dominant negative form of CREB suppressed *induced* [CREB] phosphorylation and c-fos mRNA expression . Positive_regulation CREB3 TNF 15753227 1380086 and glucose *induced* a dose- and time dependent activation of the p38 MAP kinase , the downstream kinase mitogen- and stress activated kinase 1 , and the transcription factor [cAMP-responsive element binding protein] ( CREB ) , in EPCs . Positive_regulation CREB3 TNF 16715652 1565096 *induced* phosphorylation of [CREB] with a peak at 15 min of stimulation in a dose dependent manner in bovine aortic ECs . Positive_regulation CREB3 TNF 16715652 1565125 Pharmacological inhibition of p38 mitogen activated protein kinase ( p38-MAPK ) inhibited *induced* [CREB] phosphorylation . Positive_regulation CREB3 TNF 17082637 1643375 Our findings collectively indicate that ERK signaling plays key roles in both Elk1 , [CREB] , and ATF-1 activation and the subsequent recruitment of c-Jun to the FRA-1 promoter in *response* to in pulmonary epithelial cells . Positive_regulation CREB3 TNF 19339243 2074337 *induced* [CREB] phosphorylation in vitro and DNA binding and reporter gene activities in vivo . Positive_regulation CREB3 TNF 19339243 2074344 *induced* [CREB] activation via ERK1/2 , and inhibition of ERK1/2 and CREB blunted TNF-alpha mediated WISP1 induction . Positive_regulation CREB3 TNFSF10 12807432 1101898 Moreover , *increased* CREB phosphorylation and [phospho-CREB] DNA binding activity in a phosphatidylinositol 3-kinase (PI 3K)/Akt dependent manner . Positive_regulation CREB3L2 MAPK1 22495181 2624607 Both and phosphatidylinositol-3 kinase pathways via IGF-I receptor activation were *required* for [BBF2H7] induction . Positive_regulation CREB3L2 MAPK10 22495181 2624608 Both and phosphatidylinositol-3 kinase pathways via IGF-I receptor activation were *required* for [BBF2H7] induction . Positive_regulation CREB3L2 MAPK11 22495181 2624609 Both and phosphatidylinositol-3 kinase pathways via IGF-I receptor activation were *required* for [BBF2H7] induction . Positive_regulation CREB3L2 MAPK12 22495181 2624610 Both and phosphatidylinositol-3 kinase pathways via IGF-I receptor activation were *required* for [BBF2H7] induction . Positive_regulation CREB3L2 MAPK13 22495181 2624611 Both and phosphatidylinositol-3 kinase pathways via IGF-I receptor activation were *required* for [BBF2H7] induction . Positive_regulation CREB3L2 MAPK14 22495181 2624612 Both and phosphatidylinositol-3 kinase pathways via IGF-I receptor activation were *required* for [BBF2H7] induction . Positive_regulation CREB3L2 MAPK15 22495181 2624606 Both and phosphatidylinositol-3 kinase pathways via IGF-I receptor activation were *required* for [BBF2H7] induction . Positive_regulation CREB3L2 MAPK3 22495181 2624613 Both and phosphatidylinositol-3 kinase pathways via IGF-I receptor activation were *required* for [BBF2H7] induction . Positive_regulation CREB3L2 MAPK4 22495181 2624614 Both and phosphatidylinositol-3 kinase pathways via IGF-I receptor activation were *required* for [BBF2H7] induction . Positive_regulation CREB3L2 MAPK6 22495181 2624615 Both and phosphatidylinositol-3 kinase pathways via IGF-I receptor activation were *required* for [BBF2H7] induction . Positive_regulation CREB3L2 MAPK7 22495181 2624616 Both and phosphatidylinositol-3 kinase pathways via IGF-I receptor activation were *required* for [BBF2H7] induction . Positive_regulation CREB3L2 MAPK8 22495181 2624617 Both and phosphatidylinositol-3 kinase pathways via IGF-I receptor activation were *required* for [BBF2H7] induction . Positive_regulation CREB3L2 MAPK9 22495181 2624618 Both and phosphatidylinositol-3 kinase pathways via IGF-I receptor activation were *required* for [BBF2H7] induction . Positive_regulation CREB5 ADRB2 15024018 1243886 stimulation *increased* [CREB] phosphorylation , OCA-B expression , and OCA-B binding to the 3'-IgH enhancer in a protein kinase A-dependent manner , an effect lost when beta2-adrenergic receptor-deficient B cells were used . Positive_regulation CREB5 ADRB2 23436577 2771352 activation in Treg cells *leads* to increased intracellular cAMP levels and to protein kinase A (PKA) dependent [CREB] phosphorylation . Positive_regulation CREB5 CAPN8 18982459 1989681 After outlining the major features of different cell death mechanisms in general , we then compare them with results obtained in retinal degeneration models , where photoreceptor cell death appears to be governed by , among other things , changes in cyclic nucleotide metabolism , downregulation of the transcription factor [CREB] , and excessive *activation* of and PARP . Positive_regulation CREB5 CAPN8 23799606 2807926 Our results clearly showed that ICV injection of NPD1 at 2 h after reperfusion improves the neurological status of middle cerebral artery occlusion ( MCAO ) rats through the inhibition of TRPC6 proteolysis and the subsequent *activation* of [CREB] via the Ras/MEK/ERK pathway . Positive_regulation CREB5 CAPN8 24193141 2885956 In conclusion , the results clearly demonstrated that intracerebroventricular injection of EGCG immediately following ischemia , inhibits ERS and improves the neurological status of rats that have undergone middle cerebral artery occlusion via the inhibition of TRPC6 proteolysis and the subsequent *activation* of [CREB] via the MEK/extracellular signal regulated kinases ( ERK ) pathway . Positive_regulation CREB5 CCND1 12391146 1001670 We describe an alternative mechanism for [CREB-driven] *induction* that involves the ubiquitous POU domain protein Oct-1 . Positive_regulation CREB5 CCND1 16522741 1531506 Taken together , EX-induced expression is largely dependent on the cAMP/PKA signaling pathway , and EX *increases* the level of phosphorylated [CREB] and more potently trans-activates cyclin D1 gene through binding of the CREB to the putative CRE site , implicating a potential mechanism underlying beta-cell proliferation by EX . Positive_regulation CREB5 EPHB2 11371570 834842 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and and *activation* of [cAMP-responsive element binding protein] ( CREB ) , NF-kappaB , and E2F ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation CREB5 EPHB2 11682632 874322 activation by the PKA pathway was not *required* for [CREB/ATF-1] phosphorylation but rather was necessary for CREB dependent up-regulation of C/EBPs expression . Positive_regulation CREB5 EPHB2 11682632 874326 Our findings suggest that activation is *required* for [CREB] transcriptional activity , possibly by recruitment of a coactivator . Positive_regulation CREB5 EPHB2 12008033 940697 We compared the BCR *induced* intracellular [ Ca2+ ] transient , protein tyrosine phosphorylation and phosphorylation , furthermore , the activation of Elk-1 and [CREB] transcription factors . Positive_regulation CREB5 EPHB2 12200150 982766 [CREB] DNA binding activation by a 50-Hz magnetic field in HL60 cells is *dependent* on extra- and intracellular Ca ( 2+ ) but not PKA , PKC , , or p38 MAPK . Positive_regulation CREB5 EPHB2 12529240 1084524 Both early gene activation and [CREB] phosphorylation were *inhibited* by phosphorylation blockade . Positive_regulation CREB5 EPHB2 15265911 1275528 We also show that [CREB] is activated downstream of the pre-TCR complex , and that the induction of CREB activity is *regulated* by protein kinase C alpha- and mediated signals . Positive_regulation CREB5 EPHB2 15383527 1334756 DNA precipitation assays and DNA decoy experiments indicated that *dependent* activation of [CREB] binding to a CRE/AP-1 like element ( designated `` CRE2 '' ) at the position of -413 largely contributed to the transcriptional effects of FSS . Positive_regulation CREB5 EPHB2 15389611 1300398 Second , while phosphorylation of and RSK are modulated by visual experience , phosphorylation of [CREB] at serines 133 , 142 , or 143 is *detected* constitutively and is unaffected by experience . Positive_regulation CREB5 EPHB2 15709700 1351761 We present novel results from our laboratory showing mediated [CREB] *activation* by hydrogen peroxide . Positive_regulation CREB5 EPHB2 16151051 1499393 In this study , we tested the hypotheses that oxidants induce Ca2+ mediated phosphorylation of and CREB , and that [CREB] is *required* for oxidant induced proliferation and apoptosis . Positive_regulation CREB5 EPHB2 16164634 1456330 Inhibition of also *inhibited* [CREB] activation . Positive_regulation CREB5 EPHB2 16168389 1461540 IGF-1 induced [CREB] phosphorylation was *mediated* by , PI3-K , p38-MAPK , as well as Ca ( 2+ ) /calmodulin kinase and calcineurin . Positive_regulation CREB5 EPHB2 16516913 1549249 The p38MAPK inhibitor , SB203580 , and the kinase inhibitor , PD98059 each partially *inhibited* exogenous AII conferred [CREB] activation confirming that p38MAPK and ERK1/2 mediate CREB phosphorylation in this system . Positive_regulation CREB5 EPHB2 16854387 1600387 Short chain fatty acids induce TH gene expression via *dependent* phosphorylation of [CREB] protein . Positive_regulation CREB5 EPHB2 16923128 1603102 Taken together , NGF induced PC12 cell differentiation requires pathway *mediated* activation of [CREB] . Positive_regulation CREB5 EPHB2 17074386 1708959 We propose that ryanodine receptor stimulation by activity generated redox species produces calcium release signals that may contribute significantly to hippocampal synaptic plasticity , including plasticity that requires long lasting *dependent* [CREB] phosphorylation . Positive_regulation CREB5 EPHB2 17082637 1643366 inhibition not only *blocked* phosphorylation of Elk1 , [CREB] , and ATF1 , which constitutively bind to the FRA-1 promoter , but also suppressed the recruitment of c-Jun to the promoter . Positive_regulation CREB5 EPHB2 17582742 1774449 Moreover , both baclofen and CGP7930 induce *dependent* [CREB] phosphorylation . Positive_regulation CREB5 EPHB2 18205034 1863785 Activation of PKA , PKC , and p38 MAPK is *involved* in preconditioning induced [CREB] phosphorylation . Positive_regulation CREB5 EPHB2 18837011 1988207 *mediates* activity dependent neuronal complexity via sustained activity and [CREB] mediated signaling . Positive_regulation CREB5 EPHB2 19385062 2069347 The exchange protein directly activated by cAMP ( Epac ) activator , 8CPT-2Me-cAMP , promoted the Akt/eNOS/NO pathway and phosphorylation , but did not *induce* [CREB] phosphorylation and VEGF expression . Positive_regulation CREB5 EPHB2 19508427 2108606 The sustained activation of but a transient *activation* of [CREB] together suggest that exposure to homocysteine initiates a feedback loop that shuts off CREB signaling without affecting ERK phosphorylation and thereby facilitates homocysteine mediated neurotoxicity . Positive_regulation CREB5 EPHB2 21798274 2490266 In addition , P2Y(13) and P2X7 receptor agonists were also able to phosphorylate and activate the *dependent* target [CREB] , which could be involved in their neuroprotective effect . Positive_regulation CREB5 EPHB2 22916239 2657610 These results show that luteolin induces the up-regulation of miR-132 , which serves as an important regulator for neurotrophic actions , mainly acting through the activation of cAMP/PKA- and *dependent* [CREB] signaling pathways in PC12 cells . Positive_regulation CREB5 EPHB2 24048848 2842882 In vitro , estrogen receptor a (ERa) signaling through metabotropic glutamate receptor 1a ( mGluR1a ) leads to *dependent* [CREB] phosphorylation ( Boulware et al. , 2005 ) , suggesting that interactions between ERs and mGluR1a may be vital to the memory enhancing effects of E2 . Positive_regulation CREB5 EPHB2 9528766 496062 Inhibition of either the or the p38/MAPKAP kinase 2 pathway only partially *blocked* NGF induced [CREB] Ser-133 phosphorylation , suggesting that either pathway alone is sufficient for coupling the NGF signal to CREB activation . Positive_regulation CREB5 EPHB2 9808472 545200 The sequential activation of and Rsk2 by Ca2+ *leads* to the phosphorylation and transactivation of [CREB] . Positive_regulation CREB5 EPHB2 9808472 545234 Furthermore , the full expression of the late phase of long-term potentiation ( L-LTP ) and L-LTP associated CRE mediated transcription requires ERK activation , suggesting that the *activation* of [CREB] by plays a critical role in the formation of long lasting neuronal plasticity . Positive_regulation CREB5 GLP1R 23188390 2723922 In insulinoma cell lines , the expression of exogenous *restored* cAMP production and the phosphorylation of [CREB] . Positive_regulation CREB5 IL1B 10397405 627818 This was demonstrated by showing that coexpression of [CREB] stimulated native but not CRE mutant promoter and that and PMA *induced* less activity with the mutant promoter as compared to the native promoter . Positive_regulation CREB5 IL1B 10965886 728050 The transcription factor [CREB] , a potential substrate of both protein kinase A (PKA) and RSK-1 , is phosphorylated in *response* to and cAMP in HepG2 cells . Positive_regulation CREB5 MAP2K6 10406459 629437 We further demonstrate that although inhibition of *represses* forskolin induced [CREB] activation , forskolin by itself failed to activate ERK1/2 and Elk-1 mediated transcription . Positive_regulation CREB5 MAP2K6 11591753 869552 Inhibition of activity also *inhibited* IL3 induced [CREB] phosphorylation . Positive_regulation CREB5 MAP2K6 11885780 894084 The activations of [CREB] and NF-kappaB were *blocked* by inhibitors of either p38 ( SB-203580 ) or ( PD-098059 ) , suggesting that they were events downstream of MAK kinase . Positive_regulation CREB5 MAP2K6 16061232 1442101 The activation of JAK2 or apparently *mediated* the magnolol induced phosphorylation of [CREB] and the upregulation of StAR . Positive_regulation CREB5 MAP2K6 16176063 1457690 The LPA induced phosphorylation of ERK 1/2 and [CREB] was *blocked* by inhibition of PI3K , PKC and , but that of Akt was only inhibited by wortmannin , the PI3K inhibitor . Positive_regulation CREB5 MAP2K6 18656513 1972834 was *required* for phosphorylation of ERK and [CREB] , but not Akt , whereas G ( 0 ) /G ( i ) -proteins were necessary for phosphorylation of Akt and CREB , and cGMP was necessary for Akt phosphorylation . Positive_regulation CREB5 MAP2K6 21295555 2403475 The riluzole induced [CREB] phosphorylation was completely *blocked* by a ( MEK ) inhibitor ( U0126 ) . Positive_regulation CREB5 MAP2K6 21448293 2412571 Here we describe a novel neuronal signaling pathway whereby CRF leads to a rapid Gß?- and *dependent* increase in [CREB] phosphorylation . Positive_regulation CREB5 MAP2K6 21977288 2362304 The inhibition of PKA , PKC , , p38-MAPK or PI3-kinase partially *reduced* the strain induced [CREB] phosphorylation . Positive_regulation CREB5 MAP2K6 22932066 2785931 inhibitors -- PD98059 and U0126 -- *blocked* the effect of bFGF on phosphorylated [CREB] while a p38-MAPK inhibitor -- SB203580 -- blocked the effect of IL1ß on phosphorylated CREB . Positive_regulation CREB5 MAP2K6 24185007 2875605 Preliminary analysis of biopsies from BRAF ( V600E ) melanoma patients revealed that phosphorylated ( active ) [CREB] was *suppressed* by inhibition but restored in relapsing tumours . Positive_regulation CREB5 PGC 11557984 861452 Fasting hyperglycaemia is strongly correlated with type II diabetes , so our results suggest that the *activation* of by [CREB] in liver contributes importantly to the pathogenesis of this disease . Positive_regulation CREB5 PGC 22767158 2676329 hesperetin activates PI-3 K , PKA , PKC , ERK1 and [CREB] , and it *induces* PI-3 K , PKA , and seladin-1 via both ER and TrkA ; Positive_regulation CREB5 PPBP 19224810 2039883 The *induced* increase in [CREB] phosphorylation was blocked by H89 ( 0.5 +/- 0.07 ) but not U0126 , KN62 , or LY294002 . Positive_regulation CREB5 RCAN1 21890628 2496516 Furthermore , we found that the increased *activation* of [CREB] signaling by depended on the ability of RCAN1 to inhibit calcineurin activity . Positive_regulation CREB5 RCAN1 21890628 2496522 Our data provide the first evidence that *acts* as an important regulatory component in the control of [CREB] signaling . Positive_regulation CREB5 RCAN1 23150431 2751917 Furthermore , *induced* the expression of the [CREB] target gene , Bcl-2 . Positive_regulation CREB5 RGS2 22057271 2516930 Forskolin stimulated RGS2 mRNA up-regulation is inhibited by CREB sequestration or specific disruption of the promoter interaction , and Ang II-induced [CREB] phosphorylation and nuclear localization are *blocked* by iPLA(2)ß pharmacologic inhibition or genetic ablation . Positive_regulation CREB5 SPHK1 16313513 1486939 Moreover , [CREB] phosphorylation in response to NT-3 *involves* , the enzyme that synthesizes S1P . Positive_regulation CREB5 TF 10067852 594003 These results suggest that optimal activation of the mouse promoter by FSH *requires* both [CREB] binding to the CRE-like PRII region and bHLH binding to the E-box . Positive_regulation CREB5 TLR7 21398611 2411882 Mal mediates induced *activation* of [CREB] and expression of IL-10 . Positive_regulation CREB5 TNF 10211885 607711 AP-2 and [CREB] were not *induced* by . Positive_regulation CREB5 TNF 10383461 624618 Furthermore , overexpression of CREB but not mutated CREB by retroviral mediated gene transfer reversed hypoxia elicited induction of TNF-alpha defining a causal relationship between hypoxia elicited [CREB] reduction and *induction* . Positive_regulation CREB5 TNF 10585438 571391 Stimulation of Sertoli cells with , an NF-kappaB activating cytokine produced by round spermatids located adjacent to Sertoli cells , *stimulated* the elimination of IkappaB , the translocation of additional NF-kappaB to the nucleus , and increased NF-kappaB binding to [CREB] promoter kappaB enhancer elements . Positive_regulation CREB5 TNF 10585438 571396 also *stimulated* transcription from the [CREB] promoter . Positive_regulation CREB5 TNF 10903915 713434 We demonstrated here that intracellular localization of these redox molecules differ from each other and that the redox molecules differentially regulate NF-kappaB , AP-1 , and [CREB] activation *induced* by , PMA , and forskolin and by expression of signaling intermediate kinases , NIK , MEKK , and PKA in HEK293 cells . Positive_regulation CREB5 TNF 11085968 750828 Electrophoretic mobility shift assay demonstrated that *enhanced* DNA binding of osteoblast specific factor ( Osf2 ) , AP1 , and [CREB] , transcription factors that are important for osteoblastic differentiation . Positive_regulation CREB5 TNF 14761884 1207105 Dominant negative CREB , an antagonist antibody directed against the type 1 TNF receptor , or pharmacological inhibition of p38 MAPK signaling blocked induced [CREB] *activation* as determined by phosphorylation and gene reporter assays . Positive_regulation CREB5 TNF 14761884 1207151 These observations show that [CREB] is *activated* by signaling through a p38MAPK/MSK1 signaling pathway . Positive_regulation CREB5 TNF 15242860 1289511 *induced* [CREB] phosphorylation with a peak at 15 minutes of stimulation . Positive_regulation CREB5 TNF 15242860 1289514 Pharmacological inhibition of p38 mitogen activated protein kinase ( p38-MAPK ) inhibited *induced* [CREB] phosphorylation . Positive_regulation CREB5 TNF 15242860 1289556 Adenovirus mediated overexpression of dominant negative form of CREB suppressed *induced* [CREB] phosphorylation and c-fos mRNA expression . Positive_regulation CREB5 TNF 15753227 1380083 and glucose *induced* a dose- and time dependent activation of the p38 MAP kinase , the downstream kinase mitogen- and stress activated kinase 1 , and the transcription factor [cAMP-responsive element binding protein] ( CREB ) , in EPCs . Positive_regulation CREB5 TNF 16715652 1565094 *induced* phosphorylation of [CREB] with a peak at 15 min of stimulation in a dose dependent manner in bovine aortic ECs . Positive_regulation CREB5 TNF 16715652 1565097 Pharmacological inhibition of p38 mitogen activated protein kinase ( p38-MAPK ) inhibited *induced* [CREB] phosphorylation . Positive_regulation CREB5 TNF 17082637 1643373 Our findings collectively indicate that ERK signaling plays key roles in both Elk1 , [CREB] , and ATF-1 activation and the subsequent recruitment of c-Jun to the FRA-1 promoter in *response* to in pulmonary epithelial cells . Positive_regulation CREB5 TNF 19339243 2074335 *induced* [CREB] phosphorylation in vitro and DNA binding and reporter gene activities in vivo . Positive_regulation CREB5 TNF 19339243 2074342 *induced* [CREB] activation via ERK1/2 , and inhibition of ERK1/2 and CREB blunted TNF-alpha mediated WISP1 induction . Positive_regulation CREB5 TNFSF10 12807432 1101896 Moreover , *increased* CREB phosphorylation and [phospho-CREB] DNA binding activity in a phosphatidylinositol 3-kinase (PI 3K)/Akt dependent manner . Positive_regulation CREBBP CCND1 17178859 1662526 Surprisingly , they were all up-regulated by 17beta-estradiol and , and cyclin D1 overexpression *increased* [p300/CBP] binding to their promoters , supporting the model that cyclin D1-estrogen receptor (ER) coactivator interactions may be important to its role in ER-positive breast cancer . Positive_regulation CREBBP EPHB2 12824291 1113640 These results indicate that *dependent* [R-Smad] linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells . Positive_regulation CRH HSD11B2 23042946 2698572 Furthermore , inhibition of activity by 18ß-glycyrrhetinic acid *resulted* in elevated whole-body cortisol levels and preoptic area mRNA abundance of [corticotropin releasing factor] and mineralocorticoid receptor . Positive_regulation CRH IL1B 10443683 635805 Among the peptides , [CRF] secretion was *stimulated* by and by endothelin-1 . Positive_regulation CRH IL1B 10657738 578350 We have found that *increased* the activity of [CRH] gene promoter , in a time- and dose dependent manner . Positive_regulation CRH IL1B 11058221 746188 The activation of neurosecretory neurons that express [corticotropin releasing hormone (CRH)] in *response* to increased circulating levels of depends on prostaglandin E ( 2 ) ( PGE ( 2 ) ) acting locally within the brain parenchyma . Positive_regulation CRH IL1B 11244300 792296 We examined the role of nucleus tractus solitarius (NTS) and ventrolateral medulla ( VLM ) catecholamine cells in the activation of mPVN [CRH] , hypothalamic oxytocin ( OT ) and central amygdala cells in *response* to ( 1 microg/kg , i.a. ) . Positive_regulation CRH IL1B 11244300 792300 First we confirmed that PVN 6-hydroxydopamine lesions , which selectively depleted catecholaminergic terminals , significantly reduced *induced* mPVN [CRH] cell activation . Positive_regulation CRH IL1B 11852909 913321 Indomethacin or dipyrone reduced LPS , , IL-6 or TNF-alpha *induced* fever and [CRH] release from rat hypothalamus . Positive_regulation CRH IL1B 12372984 996508 in the brain *stimulates* the release of [CRH] , the hypothesis was tested that the inhibition of LC activity produced by the low dose of IL-1 was mediated by CRH . Positive_regulation CRH IL1B 14698853 1195821 To investigate whether this peptide hyporesponsiveness in LEW/N cells is secondary to their deficient mRNA expression , temporal mRNA expression patterns of [CRH] , AVP , and several hypothalamic neuropeptides *induced* by in LEW/N and F344/N hypothalamic dissociated cell cultures were delineated by quantitative real-time polymerase chain reaction ( RT-PCR ) . Positive_regulation CRH IL1B 1517398 196848 *induces* [corticotropin releasing factor-41] release from cultured hypothalamic cells through protein kinase C and cAMP dependent protein kinase pathways . Positive_regulation CRH IL1B 1517398 196850 *induces* a dose dependent increase in the release of [corticotropin releasing factor-41 (CRF)] from dispersed rat fetal hypothalamic cells in culture . Positive_regulation CRH IL1B 15927699 1414204 is *involved* in hypothalamic regulation of the neuroimmune response by influencing the synthesis and secretion of [corticotropin releasing hormone (CRH)] , vasopressin ( VP ) and other stress related mediators . Positive_regulation CRH IL1B 17318020 1699903 The aim of this study was to investigate the hypothesis that might be *involved* in the increase of the circulating levels of placental derived [CRH] leading to the initiation of pre-term labor . Positive_regulation CRH IL1B 1782543 175904 On the other hand , the increase in [CRF] release *induced* by 10 nM was not affected by the combination of these two antagonists . Positive_regulation CRH IL1B 20004705 2199830 These results suggest that and NO are *involved* in NE-induced [CRH] release . Positive_regulation CRH IL1B 20004705 2199832 Moreover , we found that application of L-NNA attenuated *induced* [CRH] release , indicating that NO likely mediates this process . Positive_regulation CRH IL1B 2171341 142456 This study showed that *increases* the release of [corticotropin releasing factor] and adrenocorticotropin hormone from cultured placental cells . Positive_regulation CRH IL1B 2783532 106897 These data indicate that the central effects of on metabolic rate , body temperature , BAT activity , and white blood cell count are all *mediated* by release of [CRF] . Positive_regulation CRH IL1B 2785913 113571 In view of the essential role of central PGE2 in *induced* [CRH/ACTH] release , these findings suggest the presence of a sophisticated regulatory network in the immune-neuroendocrine interaction . Positive_regulation CRH IL1B 7566434 328496 IL-1 alpha ( 0.2 ng/ml ) , ( 0.5 ng/ml ) and IL-6 ( 10 ng/ml ) also *initiated* similar increases in the release of [CRF-41] and AVP from hypothalami from intact rats which were effectively blocked by dexamethasone ( 10 ( -7 ) M ) . Positive_regulation CRH IL1B 7628398 316423 Finally , removal of the inhibitory effect of NO either unmasks the participation of adrenergic receptors in modulating the response of the hypothalamic-pituitary axis to IL-1 beta or stimulates catecholamine secretion , which , in turn , acts on CRF nerve terminals and/or synergizes with *induced* [CRF] release . Positive_regulation CRH IL1B 7680697 211825 Application to the measurement of *stimulated* production of hypothalamic [CRF] in vitro . Positive_regulation CRH IL1B 7680697 211827 dose-dependently *stimulated* synthesis and secretion of [CRF] , demonstrating the applicability of the immunoradiometric assay , and confirming previous reports that interleukin-1 beta can directly stimulate CRF secretion from the rat hypothalamus in vitro . Positive_regulation CRH IL1B 7690108 228572 Involvement of nitric oxide in basal and *induced* [CRH] and ACTH release in vitro . Positive_regulation CRH IL1B 7690108 228573 NG-Nitro-L-arginine , an inhibitor of nitric oxide synthase , does not influence CRH basal release but is able to modify ACTH basal secretion and to block *induced* [CRH] and ACTH release from rat hypothalamic and anterior pituitary cell cultures in vitro . Positive_regulation CRH IL1B 7804604 284674 The intraadrenal content of corticotropin releasing hormone (CRH) and adrenocorticotropin ( ACTH ) immunoreactivities ( ir ) , as well as *stimulated* release of [CRH-ir] and ACTH-ir , increased in relation to the number of days elapsed from hypophysectomy ; Positive_regulation CRH IL1B 7988414 282498 The *stimulation* of [CRH] by ( 100 ng/ml ) was also significantly antagonized by hemin ( 1 microM ) . Positive_regulation CRH IL1B 8025563 263304 Stress and *induced* activation of c-fos , NGFI-B and [CRF] gene expression in the hypothalamic PVN : comparison between Sprague-Dawley , Fisher-344 and Lewis rats . Positive_regulation CRH IL1B 8025563 263306 These results provide further evidence that physical stress and central can *enhance* expression of several IEGs , as well as [CRF] , within the parvocellular division of the PVN . Positive_regulation CRH IL1B 8194703 258997 *increases* the release of [corticotropin releasing factor (CRF)] in the brain through prostaglandin pathways . Positive_regulation CRH IL1B 8381442 211963 Both and stress resulted in increased levels of CRF mRNA and when both were given together , the combination *resulted* in an additive effect on the increase in [CRF] transcripts . Positive_regulation CRH IL1B 8649215 366473 In previous experiments we have shown the role of nitric oxide ( NO ) in basal and *induced* [CRH] and ACTH release in vitro . Positive_regulation CRH IL1B 9619376 510352 A number of previous studies have concluded that prostaglandins (PGs) play a crucial role in mediating the [corticotropin releasing hormone] and adrenocorticotropin ( ACTH ) secretion *induced* by in the rat . Positive_regulation CRH IL1B 9700679 525245 It is proposed that neurons in the area postrema , NTS and VLM might mediate this *induced* activation of hypothalamic [CRF] and OT cells and release of ACTH into the plasma . Positive_regulation CRH TNF 11852909 913320 Indomethacin or dipyrone reduced LPS , IL-1beta , IL-6 or *induced* fever and [CRH] release from rat hypothalamus . Positive_regulation CRH TNF 12485415 1032926 [Corticotropin releasing hormone] *induces* proliferation and release in cultured rat microglia via MAP kinase signalling pathways . Positive_regulation CRH TNF 12485415 1032951 These results suggest that [CRH] *induces* cell proliferation and release in cultured microglia via MAP kinase signalling pathways , thereby providing insight into the interactions between CRH and inflammatory mediators . Positive_regulation CRH TNF 1460089 206634 Since NA released in the ME might be involved in the modulation of corticotropin releasing factor (CRF) production , it is suggested that , through presynaptic modulation of NA release from noradrenergic nerve terminals in the ME , might *regulate* [CRF] and other neurohormone release in this hypothalamic structure . Positive_regulation CRH TNF 16081071 1442791 High [CRH] may be *caused* by increased central and IL-6 expression . Positive_regulation CRH TNF 1846105 151528 Neither IL-2 ( 1-10000 U/ml ) , IL-8 ( 0.1-10 nM ) , ( 10-1000 U/ml ) , interferon-alpha 2 ( 10-1000 U/ml ) nor interferon-gamma ( 10-1000 U/ml ) *had* any effect on hypothalamic [CRH-41] release or pituitary ACTH release . Positive_regulation CRH TNF 19996183 2199743 In the hypothalamus , produces reductions in neuropeptide Y , agouti gene related peptide , proopiomelanocortin , and melanin concentrating hormone , and *increases* [CRH] and TRH . Positive_regulation CRH TNF 2161738 133567 Preincubation of hypothalamic explants with dexamethasone , indomethacin ( 1 microM ) , eicosatetraynoic acid ( 10 microM ) , or nordihydroguaiaretic acid ( 30 microM ) resulted in inhibition of *stimulated* [CRH] secretion ( P less than 0.05 ) . Positive_regulation CRH TNF 24553014 2886236 Induced [CRH] release *involves* IL-1 , IL-6 and , for stimulation adrenocorticotropic hormone ( ACTH ) release from the anterior pituitary . Positive_regulation CRH TNF 9844122 553721 In vitro , *increased* from 3.6 +/- 1.9 pg/cell to 1797 +/- 337 in N , from 4.5 +/- 1.7 to 1724 +/- 232 in [CRF] and from 3.4 +/- 2.3 to 1244 +/- 553 in HD after the LPS stimulus . Positive_regulation CRHR1 IL1B 17431005 1748953 In contrast , *had* no effect on [CRH-R1d] mRNA expression . Positive_regulation CRIM1 EPHB2 25086356 2954017 These results demonstrate that CRIM1 is an early response gene in the presence of both angiogenic stimulation ( VEGF ) and environmental ( extracellular matrix ) factors , and and FAK might be *involved* in the upregulation of [CRIM1] mRNA expression in vascular endothelial cells . Positive_regulation CRIP1 FOLR1 15885105 1406725 and Glc6-P *stimulate* CcpA-HPrSerP but not [CcpA-CrhP] binding to cre . Positive_regulation CRK ANGPT1 17687003 1800436 We also found that MEKK3 is required for *induced* [p38] and ERK5 activation . Positive_regulation CRK ANGPT1 24308939 2877817 differentially *induces* DUSP1 , DUSP4 , and DUSP5 in human umbilical vein endothelial cells through activation of the PI-3 kinase , ERK1/2 , [p38] , and SAPK/JNK pathways . Positive_regulation CRK CCND1 10066798 593770 pp60 ( v-src ) induction of *requires* collaborative interactions between the extracellular signal regulated kinase , [p38] , and Jun kinase pathways . Positive_regulation CRK CTGF 18922143 1982008 Bile acids *induce* production through [p38] MAP kinase activation in human bronchial epithelial cells : a factor contributing to airway fibrosis . Positive_regulation CRK EPHB2 11083274 750483 Tumor necrosis factor alpha , interleukin-1 (IL-1) , and IL-6 were the major inducers of , JNK , and [p38] MAPK *activation* in cultured human synovial cells . Positive_regulation CRK EPHB2 12403788 1036153 SB203580 , a [p38] MAPK *inhibitor* , and PD98059 , an inhibitor , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation CRK EPHB2 15467832 1305793 The expression level and activation of MEK1/2 or showed no difference , but the kinase activity of apoptosis signal regulating kinase 1 ( ASK1 ) , JNK , or [p38] *increased* significantly compared with that in controls . Positive_regulation CRK EPHB2 15833106 1403932 By means of specific inhibitors we showed that [p38] and ERK act downstream of CD28 and that and JNK *act* downstream of ICOS leading to the induction of various T cell derived cytokines . Positive_regulation CRK EPHB2 17950254 1844495 Similar to SFLLRN , the TFRRR-peptide caused phosphorylation of Akt and in a P2Y ( 12 ) receptor dependent manner , and [p-38] MAP kinase *activation* in a P2Y ( 12 ) -independent manner . Positive_regulation CRK EPHB2 19033456 1998479 EKAR signals were correlated with ERK phosphorylation , *required* activity , and did not report the activities of JNK or [p38] . Positive_regulation CRK EPHB2 19664603 2125930 Taken together , our results demonstrate that lycopene inhibits PDGF-BB induced ARPE19 cell migration through inhibition of PI3K/Akt , and [p38] *activation* . Positive_regulation CRK EPHB2 20554538 2327616 The HNE enhanced Sp1 and NF-?B activities were attenuated by SB203580 , a [p38] mitogen activated protein kinase (MAPK) *inhibitor* , and PD98059 , an extracellular signal regulated kinase ( ) inhibitor , respectively . Positive_regulation CRK EPHB2 21903092 2496640 In addition , knockdown of NAPA induced the activation of the MAPK kinases ERK , JNK and [p38] , but only inhibition of *reduced* synoviolin ubiquitination and p53 accumulation . Positive_regulation CRK EPHB2 22075021 2528282 The response of the pial artery to hypotension and hypercapnia was monitored in piglets equipped with a closed cranial window before and after hypoxia and ischemia in the presence or absence of U0126 , an inhibitor for the protein kinase upstream of , sp600125 , an *inhibitor* of c-Jun-N-terminal kinase or sb203580 , an inhibitor of [p38] . Positive_regulation CRK EPHB2 22948158 2688106 Pam3Cys , a specific TLR2 agonist , stimulated phosphorylation of JNK , ERK , and [p38] , but only JNK and inhibition *blocked* Pam3Cys stimulated chemotaxis . Positive_regulation CRK EPHB2 24253595 2910459 We examined the *role* of in the regulation of MKP1 and JNK , and [p38] activities and apoptosis . Positive_regulation CRK EPHB2 24324260 2921451 In contrast , action of Met on ILDFb proliferation does not require but does *require* [p38] ( MAPK ) . Positive_regulation CRK F2R 16467309 1548141 and PAR-2 stimulation rapidly *activated* both ERK1/2 and [p38MAPK] , and pharmacological blockade of MEK with either PD98059 or U0126 or of p38MAPK by SB203580 or SB202190 strongly inhibited thrombin- and SLIGKV induced COX-2 expression and 6-keto-PGF1alpha formation . Positive_regulation CRK F2R 23625915 2795623 In addition , inhibition of the SOCE downstream target CaM kinase kinase ß (CaMKKß) or knockdown of AMPKa1 suppressed *mediated* phosphorylation of [p38ß] and hence STIM1 . Positive_regulation CRK FAS 8972182 408510 In this study , crmA antagonized , and YVAD-CMK and Z-VAD-FMK completely inhibited , Fas activation of p38 kinase activity , demonstrating that *dependent* activation of [p38] requires ICE/CED-3 family members and conversely that the MKK3/p38 activation cascade represents a downstream target for the ICE/CED-3 family proteases . Positive_regulation CRK FOXO1 17303659 1725974 In contrast , increases p38 activity , and [p38] is *required* for effects of Foxo1 on PKB , at least in part . Positive_regulation CRK HRH1 17965772 1820332 is *required* for TCR mediated [p38] MAPK activation and optimal IFN-gamma production in mice . Positive_regulation CRK IL1B 10903806 713226 It has been reported recently that *induces* activation of the mitogen activated protein kinases (MAPK) [p38] and ERK1/2 in neonatal rat islets . Positive_regulation CRK IL1B 11509550 848344 Although and TNF-alpha each *increased* nuclear factor-kappa B activation and induced extracellular regulated kinase and [p38] phosphorylation , combined administration of the cytokines did not enhance either nuclear factor-kappa B or mitogen activated protein kinase activation . Positive_regulation CRK IL1B 11854442 913951 Moreover , stimulation of the cells *caused* the phosphorylation of [p38] and extracellular signal regulated kinase ( ERK ) , and IL-1 beta induced COX-2 expression was inhibited by the pretreatment of WISH cells with a p38 inhibitor , in contrast ERK upstream inhibitor had no effect . Positive_regulation CRK IL1B 12421347 1013459 In comparison , *induced* the release of PGE2 , IL-6 and activated NF-kappaB , [p38] , JNK and ERK1/2 in mixed glial cultures , but failed to induce any of these responses in microglial cell cultures . Positive_regulation CRK IL1B 12649265 1079998 *induced* the phosphorylation of [p38alpha] and p38beta2 MAPK in cardiomyocytes and stimulated RNA polymerase II binding to the COX-2 promoter , COX-2 transcription , COX-2 protein synthesis , and prostaglandin E2 ( PGE2 ) release . Positive_regulation CRK IL1B 15320915 1286575 A77 1726 partially suppressed *induced* ERK1/2 and [p38] kinase activation . Positive_regulation CRK IL1B 15489374 1359417 Consistently , *stimulated* phosphorylation of p42/p44 MAPK , [p38] , and JNK was attenuated by pretreatment with U0126 , SB-202190 , or SP-600125 , respectively . Positive_regulation CRK IL1B 15695308 1382610 A77 1726 inhibited *induced* [p38] and c-Jun N-terminal kinase 1/2 ( JNK1/2 ) activation , whereas A77 1726 did not affect IL-1beta induced NF-kappaB activation in hepatocytes . Positive_regulation CRK IL1B 16269458 1509287 On the other hand , TNFalpha and *induced* [p38] , c-Jun N-terminal kinase (JNK) , and nuclear factor (NF)kappaB activation , pathways more closely related to stress response . Positive_regulation CRK IL1B 17499220 1750901 In contrast , IL-1beta mediated ERK and JNK activations were not changed by LCY-2-CHO , while [p38] *activation* by and LCY-2-CHO displayed the non-additivity . Positive_regulation CRK IL1B 17700564 1794521 However , IL-1beta , IL-18 or IL-33 induced phosphorylation of Erk , [p38] and JNK in naïve HUCBMCs , and IL-33 or , but not IL-18 , *enhanced* the survival of naive HUCBMCs and promoted their adhesion to fibronectin . Positive_regulation CRK IL1B 19370536 2149299 *induced* JNK and [p38] activation was inhibited by LF , and LF significantly reduced the DNA binding activity of transcription factors NF-kappaB and AP-1 . Positive_regulation CRK IL1B 19962969 2204168 LT inhibited *induced* [p38] phosphorylation as well as sPLA ( 2 ) -IIA promoter activity in CHO cells . Positive_regulation CRK LBP 20133493 2226986 Time course studies on mCD14 positive cells have demonstrated that LPS stimulation induces rapid activation of nuclear factor-kappaB and [p38] in the *presence* of ( TLR4/MD-2 receptor dimerization ) as compared with stimulation without LBP ( receptor non-dimerization ) . Positive_regulation CRK MAP2K6 11085935 750679 Similarly , *activation* of JNK by Ad-MKK7D and [p38-MAPK] by resulted in the increased expression of PGHS-2 . Positive_regulation CRK MAP2K6 24253595 2910465 We examined the *role* of in the regulation of MKP1 and JNK , and [p38] activities and apoptosis . Positive_regulation CRK MAP2K6 8900184 393471 Thus , there are at least three members of p38 activator , MKK3 , MKK3b , and MAPKK6 , and may function as a major *activator* for [p38] when expressed . Positive_regulation CRK PECAM1 15502396 1327304 The osmotic-shock induced ERK activation but not [p38] MAP kinase activation was *dependent* on the engagement and was blocked by its downregulation . Positive_regulation CRK RGS2 16517124 1597945 In contrast , the activation of both JNK and [p38] unexpectedly were *increased* by , although the ability of PE to further activate the p38 pathway was reduced . Positive_regulation CRK STK39 21212262 2391928 The MST1 is a that is activated upon apoptotic stimulation , which in turn *activates* its downstream targets , [JNK/p38] , histone H2B and FOXO . Positive_regulation CRK TNF 10092503 600520 Furthermore , LL-Z-1640-2 inhibited anisomycin induced but not *induced* [JNK/p38] activation , indicating that the inhibition mechanism is signal-specific . Positive_regulation CRK TNF 10521481 653105 The study presented here shows that autoregulation of gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* [p38] mitogen activated protein (MAP) kinase activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation CRK TNF 10753189 681727 Here we show that treatment of primary rat hepatocyte cultures with nafenopin causes an increase in bioactive and that this process *requires* [p38] MAP kinase activity . Positive_regulation CRK TNF 10843427 700083 These results indicated that *induced* p38 MAP kinase activation and [p38] MAP kinase mediated RANTES production by human pulmonary vascular endothelial cells are inversely regulated by intracellular GSH levels . Positive_regulation CRK TNF 11156586 780627 To clarify these issues , we examined the effect of NAC on *induced* activation of p38 MAP kinase , MAP kinase kinase (MKK) 3 and MKK6 which are upstream regulators of p38 MAP kinase , and [p38] MAP kinase mediated IL-8 production . Positive_regulation CRK TNF 11167962 783077 The results showed that : NAC attenuated *induced* [p38] MAP kinase activation and RANTES production ; Positive_regulation CRK TNF 11167962 783079 These results indicate that cellular redox regulated by GSH is critical for *induced* p38 MAP kinase activation and [p38] MAP kinase mediated RANTES production by human BECs . Positive_regulation CRK TNF 11257445 794458 In cells expressing either wild-type ( WT ) or catalytically inactive ( CI ) -MKP-2 , there was no significant differences in *stimulated* JNK or [p38] MAP kinase activity , however hydrogen peroxide ( H2O2 ) -stimulated JNK activity was substantially reduced in WT-MKP-2 expressing clones and enhanced in cells expressing CI-MKP-2 . Positive_regulation CRK TNF 11509550 848343 Although IL-1 beta and each *increased* nuclear factor-kappa B activation and induced extracellular regulated kinase and [p38] phosphorylation , combined administration of the cytokines did not enhance either nuclear factor-kappa B or mitogen activated protein kinase activation . Positive_regulation CRK TNF 12093155 960338 in contrast , did not *activate* [p38] kinase . Positive_regulation CRK TNF 12393915 1025409 This model probiotic also inhibits *activation* of the pro-apoptotic [p38/mitogen] activated protein kinase by , interleukin-1alpha , or gamma-interferon . Positive_regulation CRK TNF 12878172 1115505 rapidly *activated* phosphorylation of extracellular signal regulated kinases ( ERKs ) , [p38] , and c-jun N-terminal kinase ( JNK ) mitogen activated protein ( MAP ) kinases in human chondrocytes . Positive_regulation CRK TNF 14607843 1200408 The induced *activation* of c-Jun N-terminal kinase (JNK) and [p38] mitogen activated protein kinases ( MAPKs ) , however , was promoted by depletion of TRP14 but not by that of Trx1 . Positive_regulation CRK TNF 14636891 1188117 Furthermore , CPPD crystals repressed the associated 6-fold *induction* of [p38] kinase phosphotransferase activity to levels associated with CPPD crystal incubation alone in a PD98059 ( 20 ng/ml ) and Wortmannin ( 100 nM ) sensitive manner . Positive_regulation CRK TNF 14688078 1190337 also *induced* the phosphorylation of [p38] . Positive_regulation CRK TNF 15701637 1388711 Our study suggests that TNFalpha induced desumoylation and cytoplasmic translocation of HIPK1 are critical in *induced* [ASK1-JNK/p38] activation . Positive_regulation CRK TNF 15737997 1403089 In stimulated cells , DHP-2 at 200 nM or MLK7 small interfering RNA completely blocked anisomycin and UV induced but had no effect on interleukin-1beta or *induced* [p38] and JNK activation . Positive_regulation CRK TNF 16043718 1441897 *induced* NF-kappaB and [p38] kinase activities and clinical symptoms of collagen induced arthritis in mice were all diminished . Positive_regulation CRK TNF 16060858 1531760 *induced* rapid phosphorylation of the stress activated [p38] and JNK ( c-Jun N-terminal kinase ) MAPKs ( mitogen activated protein kinases ) ; Positive_regulation CRK TNF 16269458 1509286 On the other hand , and IL-1beta *induced* [p38] , c-Jun N-terminal kinase (JNK) , and nuclear factor (NF)kappaB activation , pathways more closely related to stress response . Positive_regulation CRK TNF 16325162 1511658 Furthermore , APE1/ref-1 overexpression inhibited the *induced* increase in intracellular superoxide and [p38] MAPK phosphorylation . Positive_regulation CRK TNF 17258890 1725384 The effects of and FasL on GrB expression were specifically *mediated* by [p38MAPK] ( Mitogen-activated-protein-kinase ) activation . Positive_regulation CRK TNF 17389591 1735588 Our results demonstrate that RIP1 mediated AIP1 phosphorylation at the 14-3-3 binding site Ser-604 is essential for *induced* TRAF2-RIP1-AIP1-ASK1 complex formation and for the activation of [ASK1-JNK/p38] apoptotic signaling . Positive_regulation CRK TNF 17725582 1801628 MAC inhibited *induced* [p38] mitogen activated protein kinase activation and cell death in cultured Schwann cells . Positive_regulation CRK TNF 17763449 1801857 Furthermore , APC directly suppressed the production of and the *activation* of NF-kappaB and MAP kinase [p38] , and inhibitors of NF-kappaB or p38 reduced the production of MMP-9 , suggesting that APC inhibits MMP-9 by blocking TNF , NF-kappaB , and p38 . Positive_regulation CRK TNF 18029910 1827995 Ouabain did not affect *induced* activation of the MAP kinases [p38] , extracellular signal regulated kinase ( ERK ) , and c-Jun terminal NH ( 2 ) kinase ; Positive_regulation CRK TNF 18314542 1931900 P < 0.05 ) , and MKP-1 up-regulation was temporally related to the inhibition of *induced* [p38] MAPK phosphorylation . Positive_regulation CRK TNF 18364436 1912761 We , for the first time , demonstrate that binding of staphylococcal enterotoxin B to MHC-II results in activation of TNF-alpha converting enzyme , epidermal growth factor receptor , [p38MAPK] , and NF-kappaB *inducing* biphasic production . Positive_regulation CRK TNF 18593820 1953651 The TNF-alpha treatment was thought to activate c-Jun N-terminal kinase (JNK) , p38 mitogen activated protein kinase (MAPK) , and NF-kappaB inflammatory signals , since *increased* phospho-JNK and [phospho-p38] and reduced I kappaB levels . Positive_regulation CRK TNF 18981572 1983608 Rb1 also effectively blocked *induced* activation of [p38] , c-Jun N-terminal protein kinase , extracellular signal regulated kinase 1/2 and IkappaBalpha . Positive_regulation CRK TNF 19320886 2052447 at 50 microg/L *increased* the expression of phospho-ERK and [phospho-p38] , and SB203580 , but not PD98059 , could suppress the chemotaxis effect and up-regulation of ICAM-1 induced by TNF-alpha in MSCs ( p < 0.05 ) . Positive_regulation CRK TNF 19648110 2138325 This correlates with reduced *stimulated* [p38] MAPK phosphorylation . Positive_regulation CRK TNF 19879772 2203358 TGF-beta1 experience by cells leads to sustained long-term inactivation of mediated cell activation but not IL-18 induced [p38] *activation* suggesting transcriptional silencing of the T-BET and/or IFNG promoter independent of MAPK signalling . Positive_regulation CRK TNF 20007578 2174978 In human pulmonary microvascular ECs , AR activity was required for *induced* activation of the Rho kinase/MKK4/JNK pathway and IL-6 production , but not [p38] activation or ICAM-1 expression . Positive_regulation CRK TNF 20071450 2194123 Low *induced* NF-kappaB and [p38] phosphorylation levels in leucocytes in tumour necrosis factor receptor associated periodic syndrome . Positive_regulation CRK TNF 20071450 2194126 Because the pathomechanism of TRAPS may involve aberrant TNF mediated intracellular signalling , we examined phosphorylation levels of nuclear factor kappaB (NF-kappaB) and [p38] in *response* to in 10 patients with three different TNFRSF1A mutations ( C73R , C88Y and F112I ) . Positive_regulation CRK TNF 20091890 2212750 In addition , ACSO also inhibited *induced* phosphorylation of JNK , ERK1/2 and IkappaB , but not [p38] . Positive_regulation CRK TNF 20646342 2292571 *induced* a significant increase in [p38] MAPK phosphorylation . Positive_regulation CRK TNF 21422246 2416776 Moreover , hybrid-type , but not complex-type , N-glycans are required for induced [p38-MAPK] *activation* and subsequent phenotypic maturation of BMDCs ( MHC-II , CD86 , CCR7 upregulation ) . Positive_regulation CRK TNF 21468920 2413236 A signal transduction study revealed that polyozellin significantly attenuates *mediated* [p38] phosphorylation , inhibitory factor ?Ba degradation , and nuclear factor-?B mediated transcriptional activation . Positive_regulation CRK TNF 21811927 2462724 Treatment with OD 78 inhibited *mediated* [p38] phosphorylation , but did not change the activation of extracellular signal regulated kinase or c-Jun N-terminal kinase . Positive_regulation CRK TNF 22210374 2549839 Stereocalpin A reduced *induced* production of intracellular reactive oxygen species ( ROS ) and phosphorylation of [p38] , ERK , JNK and Akt . Positive_regulation CRK TNF 22280832 2564969 Ohioensin F reduced *induced* production of intracellular reactive oxygen species ( ROS ) and phosphorylation of [p38] , ERK , JNK and Akt . Positive_regulation CRK TNF 22294037 2586298 The RNA synthesis inhibitor actinomycin D , but not p38-specific inhibitor SB203580 , reversed the inhibitory effect of nocodazole on induced [p38] *activation* . Positive_regulation CRK TNF 22326051 2580600 Furthermore , leonurine also suppressed the *activated* [p38] phosphorylation and I?Ba degradation . Positive_regulation CRK TNF 23184810 2718247 Furthermore , we show that pentoxifylline and propentofylline also inhibit JNK and [p38] , but not ERK , activation *induced* by . Positive_regulation CRK TNF 23933846 2902044 Treatment with honokiol also reduced *induced* phosphorylation of [p38] , extracellular signal regulated kinase 1/2 , and c-Jun N-terminal kinase . Positive_regulation CRK TNF 24574500 2924835 *induced* phosphorylation of p65-Ser ( 536 ) , [p38] , and c-jun was inhibited , and basal inhibitory p65-Ser ( 468 ) phosphorylation was increased in tolerant cells . Positive_regulation CRK TNF 8662702 367176 additionally *caused* rapid [p38] and JNK-1 mitogen activated protein kinase activation and efficient NF-kappaB translocation , which could not be achieved even by high levels of ceramide . Positive_regulation CRK TNF 9177222 434130 Expression of activated MEKK1 ( DeltaMEKK1 ) in MC/9 cells strongly stimulated JNK activity but only weakly stimulated [p38] activity , and it *induced* a large activation of promoter regulated luciferase gene expression . Positive_regulation CRK TNF 9305639 454087 Overexpression of a dominant negative MTK1 mutant [ MTK1 ( K/R ) ] strongly inhibited the activation of the p38 pathway by environmental stresses ( osmotic shock , UV and anisomycin ) , but not the [p38] *activation* by the cytokine . Positive_regulation CRK TNF 9770326 538795 Furthermore , *induction* of p42/p44 ERK and [p38-MAPK] phosphorylation , c-jun kinase activation , and IkappaBalpha degradation were normal . Positive_regulation CRK TNFSF10 19895579 2176167 Preceding cell death , *activated* nuclear factor kappaB , c-Jun N-terminal kinase , [p38] and p42/44 . Positive_regulation CRK TNFSF10 23456625 2787399 Here , we examined the consequences and mechanisms of *induced* MAPKs [p38] and JNK in non-small cell lung cancer ( NSCLC ) cells . Positive_regulation CRKL CCND1 22753141 2853499 Further analysis of cell cycle related molecules showed that [CRKL] *induced* , cyclin B1 expression , and increased Rb phosphorylation . Positive_regulation CRKL EPHB2 11443118 850432 Overexpression of Lyn induced constitutive phosphorylation of [CrkL] and *activation* of , whereas that of a Lyn mutant lacking the tyrosine kinase domain attenuated the Epo induced phosphorylation of CrkL and activation of Erk . Positive_regulation CROT IL1B 16806191 1580409 Here , we show that COT activation also requires catalytic subunit phosphorylation , since *induced* a 5-10-fold activation of a [COT] mutant unable to bind p105 . Positive_regulation CROT TNF 16806191 1580402 The protein kinase [COT/Tpl2] is *activated* by interleukin-1 (IL-1) , and lipopolysaccharide , and its activation by these agonists involves the IkappaB kinase beta (IKKbeta) catalysed phosphorylation of the p105 regulatory subunit . Positive_regulation CRP IL1B 14656692 1177196 Our findings suggest that in healthy people , basal [CRP] levels are *regulated* by but not by IL6 genetics . Positive_regulation CRP IL1B 18262272 1884930 *stimulates* acute phase response and [C-reactive protein] synthesis by inducing an NFkappaB- and C/EBPbeta dependent autocrine interleukin-6 loop . Positive_regulation CRP IL1B 18262272 1884938 C/EBPbeta-overexpression in Hep3B-cells reconstituted mediated [IL-6/CRP] *inducibility* . Positive_regulation CRP IL1B 2454996 93467 These results indicate that human SAA and [CRP] are *induced* in Hep 3B cells by products of activated monocytes but not by , TNF-alpha , or some hepatocyte stimulating factor preparations and that a group of heterogeneous mechanisms are involved in the induction of the various human APP . Positive_regulation CRP IL1B 8482924 218894 [C-reactive protein] *increases* production of IL-1 alpha , , and TNF-alpha , and expression of mRNA by human alveolar macrophages . Positive_regulation CRP IL1B 9256609 448378 *induced* both [CRP] and SAA production but only in the co-presence of IL-6 . Positive_regulation CRP TNF 20676742 2447318 [C-reactive protein] *induces* secretion by p38 MAPK-TLR4 signal pathway in rat vascular smooth muscle cells . Positive_regulation CRP TNF 22088250 2509105 To investigate the effects of atorvastatin on [C-reactive protein (CRP)] *induced* Toll-Like receptor 4 (TLR4)expression on CD14+ monocyte , and the production of proinflammatory cytokines , interleukin-6 (IL-6) , matrix metalloproteinases-9 (MMP-9) , and to study the anti-inflammatory mechanisms of statins . Positive_regulation CRP TNF 2454996 93466 These results indicate that human SAA and [CRP] are *induced* in Hep 3B cells by products of activated monocytes but not by IL-1 beta , , or some hepatocyte stimulating factor preparations and that a group of heterogeneous mechanisms are involved in the induction of the various human APP . Positive_regulation CRP TNF 8482924 218892 [C-reactive protein] *increases* production of IL-1 alpha , IL-1 beta , and , and expression of mRNA by human alveolar macrophages . Positive_regulation CRP TNF 9777287 540244 The other proinflammatory cytokines IL-1 beta , and remained unchanged , and the increased serum IL-6 did not *induce* production of [c-reactive protein] . Positive_regulation CRS AXIN2 15790973 1386510 The *role* of in calvarial morphogenesis and [craniosynostosis] . Positive_regulation CRS AXIN2 23300083 2742245 Runx2 protein represses expression in osteoblasts and is *required* for [craniosynostosis] in Axin2-deficient mice . Positive_regulation CRS AXIN2 23300083 2742247 To determine whether Runx2 contributes to the etiology of deficiency *induced* [craniosynostosis] , we generated Axin2 ( -/- ) : Runx2 ( +/- ) mice . Positive_regulation CRS IL1B 17578498 1778946 The expression of some members of group II subfamily of sPLA(2)s is upregulated in [CRS] and it may *result* from and TNF-alpha overexpression . Positive_regulation CRS TNF 17578498 1778945 The expression of some members of group II subfamily of sPLA(2)s is upregulated in [CRS] and it may *result* from IL-1beta and overexpression . Positive_regulation CRTC1 ETV7 20801936 2318211 Analysis of in vivo labeled nascent protein complexes showed that and Hsp90 *mediate* the formation of the mTOR [TORC1] and TORC2 complexes and the association of ATR with ATRIP . Positive_regulation CRTC1 FOXO1 22560223 2591325 Here we show that when [TORC1] is inhibited genetically in C. elegans , SKN-1/Nrf , and *activate* protective genes , and increase stress resistance and longevity . Positive_regulation CRTC1 MAP2K6 23903755 2822387 We found that suppression of [TORC1] activity in *response* to RAF or inhibitors , as measured by decreased phosphorylation of ribosomal protein S6 (P-S6) , effectively predicted induction of cell death by the inhibitor in BRAF-mutant melanoma cell lines . Positive_regulation CRTC2 ETV7 20801936 2318213 Analysis of in vivo labeled nascent protein complexes showed that and Hsp90 *mediate* the formation of the mTOR TORC1 and [TORC2] complexes and the association of ATR with ATRIP . Positive_regulation CRY1 TNF 23496259 2803947 *enhanced* the mRNA expression of Bmal1 and [Cry1] but did not affect that of Clock , Per1 , or Cry2 . Positive_regulation CRYAB MAP2K6 10816593 714756 ( Glu ) also *induced* p38 dependent activation of the downstream MAPK activated protein kinase , MAPKAP-K2 , and the phosphorylation of [alphaB-crystallin] on serine-59 . Positive_regulation CRYAB SMN2 16129694 1474758 Co-immunoprecipitation experiments suggested that the import of [alphaB-crystallin] is possibly *regulated* by its phosphorylation dependent interaction with the , an important factor in small nuclear ribonucleoprotein nuclear import and assembly . Positive_regulation CRYGEP CTGF 23827951 2820813 stimulation *resulted* in the significant production of IL-6 , IL-8 , [C-C motif ligand 2 (CCL2)] , CCL20 , MMP-1 and MMP-3 in FLSs in the presence , but not in the absence , of IL-1ß . Positive_regulation CRYGEP TNF 19126414 2031870 In addition , knockdown of RIG-I partially inhibited the *induced* expression of [CC chemokine ligand (CCL)] 5 , a chemokine with chemotactic activity toward lymphocytes and monocytes . Positive_regulation CSDE1 TNF 12040173 949657 A common feature of each pathway is the *induced* formation of a [multiprotein] signaling complex at the cell membrane . Positive_regulation CSE CTGF 21928352 2524991 These findings suggest that *contributes* to the [CSE] and nicotine induced proliferation of rPASMCs at least in part by upregulating cyclin D1 expression . Positive_regulation CSE EPHB2 15347670 1333733 Blocking the action of ERK with U0126 inhibited the induction of p21Cip/WAK-1 , suggesting that activation functions upstream of p21Cip/WAK-1 activation to *initiate* the [CSE] overexpression induced cell growth inhibition . Positive_regulation CSE EPHB2 19299917 2064143 In isolated rat AMs , [CSE] *induced* MMP-9 expression and phosphorylation of and Akt . Positive_regulation CSE TNF 19190237 2061273 IL-1beta increased the ChAT and M ( 3 ) , down-regulated M ( 2 ) , and [CSE] *increased* ChAT and M ( 3 ) expression while down regulating the expression of M ( 2 ) in HFL-1 cells . Positive_regulation CSF1 CAPN8 8513862 221914 The loss of [M-CSF] receptors induced by LPS can be *inhibited* by neomycin and compound 48/80 , two potent phospholipase C (PLC) inhibitors , but not by phospholipase A2 , , protein kinase C ( PKC ) or protease inhibitors . Positive_regulation CSF1 EPHB2 16357167 1492794 Constitutive activation of the extracellular signal regulated kinase ( ERK ) pathway also enhanced PDEF induced motility and invasion , suggesting that *activation* of the activated protein kinase by ErbB2 and [CSF-1R/CSF-1] can cooperate with PDEF to promote motility and invasion . Positive_regulation CSF1 EPHB2 22073305 2504461 The ablated osteoclast formation in LIS1 depleted macrophages was associated with a significant decrease in macrophage proliferation , osteoclast survival and differentiation , which were caused by reduced *activation* of and AKT by [M-CSF] , prolonged RANKL induced JNK activation and declined expression of NFAT-c1 , a master transcription factor of osteoclast differentiation . Positive_regulation CSF1 FAS 8870694 389448 Macrophage colony stimulating factor ( [M-CSF] ) , which is present at increased levels in MRL/lpr mice , but not in MRL/Mp- +/+ ( MRL/+ ) mice , *induced* the expression of Mac-2 antigen and antigen on spleen adherent cells of MRL/+ mice . Positive_regulation CSF1 IL1B 12569227 1057228 Plasma interleukin (IL)-6 , IL-8 , IL-10 , granulocyte colony stimulating factor ( G-CSF ) , [macrophage CSF (M-CSF)] , and monocyte chemotactic protein 1 (MCP-1) increased significantly after the race , and urine , IL-6 , G-CSF , M-CSF , and MCP-1 *increased* significantly . Positive_regulation CSF1 IL1B 1381374 196065 These results demonstrate that production of [CSF-1] by placental villous core mesenchymal cells can be *stimulated* by in vitro and suggest that decidual IL-1 may regulate placental CSF-1 production in vivo . Positive_regulation CSF1 IL1B 1713637 163462 In contrast , , TNF , and TPA equally *stimulated* increased levels of [M-CSF] , GM-CSF , IL-1 beta and IL-6 RNAs . Positive_regulation CSF1 IL1B 17666255 1776757 stimulation of nasal polyp fibroblasts *induced* expression of RANKL mRNA and secretion of [M-CSF] . Positive_regulation CSF1 IL1B 18159995 1838568 Among cytokines analyzed in the present study , , IL-5 , IL-6 , IL-12 p40 , G-CSF , IFN-gamma , KC , LIF , MIP2 , and PDGF BB increased during the early phase of cerebral wound healing , and [M-CSF] *increased* during the middle phase , while IL-15 , IL-18 , and MIG increased during the late phase . Positive_regulation CSF1 IL1B 2012180 156677 In addition , and TNF-alpha *induced* high levels of granulocyte-macrophage colony stimulating factor ( GM-CSF ) and macrophage colony stimulating factor ( [M-CSF] ) mRNAs . Positive_regulation CSF1 IL1B 8019788 262811 Stimulation of the cells with *caused* a marked increase of GM-CSF , IL-8 , IL-6 and as well as of [M-CSF] mRNA levels . Positive_regulation CSF1 IL1B 8301137 248691 This study was undertaken to study the mechanisms leading to the *induced* up-regulation of [M-CSF] production and to determine how the antiinflammatory cytokines , IL-4 and IL-10 , affect M-CSF production in this system . Positive_regulation CSF1 IL1B 8301137 248692 We demonstrate that *enhanced* [M-CSF] mRNA levels , in part , by increasing M-CSF gene transcription but had no effect on M-CSF message half-life . Positive_regulation CSF1 IL1B 8301137 248693 The enhancement of [M-CSF] message levels in the *presence* of was blocked by cycloheximide , suggesting that de novo protein synthesis was required . Positive_regulation CSF1 IL1B 8315354 222822 We demonstrate with elutriation purified human monocytes that , in contrast to lipopolysaccharide , recombinant human [CSF-1] does not *induce* secretion of prostaglandin E2 , interleukin-6 (IL-6) , , or tumor necrosis factor alpha , as measured by immunoassay ; Positive_regulation CSF1 IL1B 8445029 213749 Since *stimulates* [CSF-1] production in a variety of mesenchymal cell types including second trimester villous core mesenchymal cells , the present study was designed to determine if IL-1 beta could also regulate CSF-1 production in term placental explants in vitro . Positive_regulation CSF1 IL1B 8445029 213751 These results demonstrate that can *regulate* placental [CSF-1] production in vitro and suggest that maternal decidual IL-1 beta may regulate placental CSF-1 production in vivo . Positive_regulation CSF1 ITGAL 1371132 179599 Stimulation of cells with antibodies to the monocyte surface Ag MAC-1 , , and ICAM-1 did not *result* in [M-CSF] secretion . Positive_regulation CSF1 PLAU 10411006 630614 PAI-2 mRNA levels generally varied inversely from those of its target , urokinase-type plasminogen activator ( uPA ) , and the macrophage growth factor [CSF-1] , which *induces* , inhibited PAI-2 expression in cells treated subsequently with LPS . Positive_regulation CSF1 PLAU 7882368 298848 Furthermore , cell surface bound *increased* from 74 % in the absence of CSF-1 to 100 % ( fully saturated ) in the presence of [CSF-1] . Positive_regulation CSF1 SELL 20925194 2332412 In our previous studies , we reported that ligation could *regulate* [CSF-1] ( colony stimulating factor-1 ) gene transcription , in which AP-1 acts as a crucial transcriptional factor . Positive_regulation CSF1 TNF 10199558 605271 Despite inhibition of NFkappaB signaling , NaS enhanced *stimulated* [MCSF] secretion and did not prevent TNFalpha stimulated increases in sMCSF mRNA , suggesting that NFkappaB was not involved in TNFalpha effect on the gene . Positive_regulation CSF1 TNF 10395651 627466 Both the soluble form of CD40 ligand ( sCD40L ) and *increased* the level of [M-CSF] and G-CSF mRNA . Positive_regulation CSF1 TNF 10395955 627707 By using a specific ELISA we found that their constitutive secretion of [M-CSF] is *enhanced* by . Positive_regulation CSF1 TNF 10395955 627708 The lipid mediator prostaglandin E2 ( PGE2 ) markedly reduces in a time- and dose dependent manner the constitutive and *induced* [M-CSF] synthesis by bone marrow stromal cells . Positive_regulation CSF1 TNF 10857771 704542 The anti-inflammatory molecules IL-10 and TGF-beta have no effect on the *induced* [M-CSF] synthesis by marrow stromal cells . Positive_regulation CSF1 TNF 10919279 717225 We have reported that osteoblasts express [CSF-1] constitutively and that , a potent bone resorbing agent , *increases* CSF-1 gene expression by a transcriptional mechanism . Positive_regulation CSF1 TNF 10919279 717226 In the present study , we report that an NF-kappaB site in the CSF-1 promoter is required for *induced* [CSF-1] expression in osteoblasts . Positive_regulation CSF1 TNF 10919279 717227 To further confirm that p50 is necessary for *induced* [CSF-1] expression in osteoblasts , CSF-1 messenger RNA expression from untreated and TNF-alpha treated osteoblasts , prepared from wild-type and p50 knock-out mice , was examined by Northern analysis . Positive_regulation CSF1 TNF 10919279 717228 Our findings support the conclusion that the NF-kappaB subunit p50 is critical for *induced* [CSF-1] expression in osteoblasts . Positive_regulation CSF1 TNF 12507582 1038415 Our results indicate that , in the presence of [M-CSF] , TNFalpha is sufficient for inducing human osteoclast differentiation from arthroplasty macrophages and that *acts* synergistically with IL-1alpha to stimulate lacunar resorption . Positive_regulation CSF1 TNF 15003795 1217306 PMMA and both *stimulated* [M-CSF] and sRANKL production whereas PMMA decreased and TNF-alpha augmented OPG release by Ob . Positive_regulation CSF1 TNF 15274652 1276719 Our data indicated that [M-CSF] and MCP-1 were *regulated* by IL-1alpha and . Positive_regulation CSF1 TNF 1532988 183377 Different molecular mechanisms lead to same endpoints with different function : *induces* non-functional [CSF-1] receptors on HL-60 cells in contrast to interferon-gamma . Positive_regulation CSF1 TNF 15479886 1319914 IL18 , IL1 beta , and did not *induce* [M-CSF] , GM-CSF , IFN gamma , or OPG production in PHA prestimulated T cells or RA synovial T cells . Positive_regulation CSF1 TNF 16006772 1447354 The levels of circulating interleukin (IL)-6 , IL-8 , macrophage colony stimulating factor ( [M-CSF] ) and interleukin 1 receptor antagonist ( IL-1ra ) significantly *increased* with the clinical stage of CRC , and the levels of IL-6 , soluble tumor necrosis factor ( sTNF ) receptor type I ( RI ) , soluble interleukin 2 receptor alpha and with tumor grade , while IL-6 , IL-8 , M-CSF , IL-1ra and sTNF RI levels significantly rose with bowel wall invasion . Positive_regulation CSF1 TNF 1623556 191518 Production of macrophage colony stimulating factor ( [M-CSF] ) by human monocytes is differentially *regulated* by GM-CSF , , and IFN-gamma . Positive_regulation CSF1 TNF 1623556 191528 Both and IFN-gamma *enhanced* [M-CSF] message levels induced by GM-CSF , but only TNF alpha synergized with GM-CSF in the induction of M-CSF protein secretion . Positive_regulation CSF1 TNF 16294221 1484666 *stimulated* [M-CSF] gene expression , in vivo , only in the presence of TNF-responsive stromal cells . Positive_regulation CSF1 TNF 16734568 1566216 Because osteoclastogenesis requires the presence of macrophage colony stimulating factor ( M-CSF ) , we examined whether HPDL cells secrete [M-CSF] in *response* to . Positive_regulation CSF1 TNF 1698425 141449 Previous work suggested that *induces* [M-CSF] gene expression through activation of phospholipase A2 and eicosanoid production . Positive_regulation CSF1 TNF 1713637 163461 In contrast , IL-1 beta , , and TPA equally *stimulated* increased levels of [M-CSF] , GM-CSF , IL-1 beta and IL-6 RNAs . Positive_regulation CSF1 TNF 1739124 182036 Bacterial lipopolysaccharide (LPS) , recombinant human interleukin-1 alpha (IL-1 alpha) or *induced* [MCSF] mRNA accumulation in a concentration dependent manner in both EC and SMC . Positive_regulation CSF1 TNF 17922812 1825261 Only the NF-kappaB blocker dimethylfumarate and the dn IKK2 , but not januskinase inhibitor-1 (JNK-I) , were able to block the *induced* increase in [M-CSF] production in these cells , suggesting that the induction of M-CSF through TNF-alpha is mainly dependent on the activation of the NF-kappaB pathway . Positive_regulation CSF1 TNF 1912581 167578 Previous studies have demonstrated that *induces* transcription of the [M-CSF] gene in human myeloid cells . Positive_regulation CSF1 TNF 1990292 152373 necrosis factor transiently *induced* the expression of [CSF-1] and inhibited the differentiation of H-1/A cells into adipocytes . Positive_regulation CSF1 TNF 19906951 2189179 TSA , valproate , and the knockdown of HDAC1 or HDAC2 significantly reduced [CSF-1] *induced* by in renal tubular cells . Positive_regulation CSF1 TNF 2012180 156676 In addition , IL-1 beta and *induced* high levels of granulocyte-macrophage colony stimulating factor ( GM-CSF ) and macrophage colony stimulating factor ( [M-CSF] ) mRNAs . Positive_regulation CSF1 TNF 2105339 126985 We also studied the signal transduction mechanisms responsible for regulating *induced* [CSF-1] mRNA levels . Positive_regulation CSF1 TNF 2105339 126986 Both 4-bromophenacyl bromide and quinacrine , inhibitors of phospholipase A2 activity , blocked *induced* increases in [CSF-1] transcripts in a concentration dependent manner , while caffeic acid and nordihydroguaiaretic acid , inhibitors of the 5-lipoxygenase pathway , had no detectable effect on induction of CSF-1 RNA . Positive_regulation CSF1 TNF 2105339 126987 These findings suggest that the increase in CSF-1 RNA observed during TNF treatment is regulated , at least in part , by both transcriptional and posttranscriptional mechanisms , and that PGE2 and cAMP regulate transcriptional *activation* of the [CSF-1] gene by . Positive_regulation CSF1 TNF 21181166 2499626 On the other hand , [M-CSF] mRNA expression level was significantly *induced* by both IL-1ß and by up to 7- and 11-fold , respectively . Positive_regulation CSF1 TNF 2551961 119066 The reduction in [CSF-1] binding activity was reversed by prolonged incubation at 37 degrees C even in the *presence* of . Positive_regulation CSF1 TNF 7622526 315874 The *induction* of [M-CSF] mRNA expression by either oxidized low density lipoprotein ( ox-LDL ) or was attenuated by NO donors , S-nitrosoglutathione ( GSNO ) , sodium nitroprusside ( SNP ) , and 3-morpholinosydnonimine , but not by cGMP analogues , glutathione , or nitrite . Positive_regulation CSF1 TNF 7912999 262030 It was found that IL-12 induces mRNA accumulation and production of GM-CSF and from both T and NK cells and , as tested on NK cells only , *induces* [M-CSF] mRNA accumulation . Positive_regulation CSF1 TNF 8347686 227011 A specific radioimmunoassay was employed to demonstrate that human articular cartilage and chondrocyte monolayers in organ and cell culture , respectively , produce macrophage colony stimulating factor ( [M-CSF] ) in *response* to stimulation with interleukin-1 alpha (IL-1 alpha) , IL-1 beta , and TNF beta . Positive_regulation CSF1 TNF 8347686 227023 Low levels of M-CSF were observed in the supernatants of nonstimulated cultures while increased levels of [M-CSF] in *response* to IL-1 alpha and were detected following 2 h exposure to the cytokines . Positive_regulation CSF1 TNF 8347686 227027 We propose that chondrocyte [M-CSF] production in *response* to IL-1 and , and the concurrent destruction of cartilage by these cytokines , could provide a mechanism for the chronic nature of rheumatoid disease . Positive_regulation CSF1 TNF 8397228 230430 We conclude that generation of reactive oxygen species , possibly by NADPH dependent oxidase , are involved in the *induction* of the JE/MCP-1 and [CSF-1] genes by and IgG complexes . Positive_regulation CSF1 TNF 8647916 366333 By Northern analysis , *caused* a dose and time ( 3 to 24 h ) dependent increase in [CSF-1] transcript expression in MC3T3-E1 cells . Positive_regulation CSF1 TNF 8647916 366335 Cycloheximide treatment of MC3T3-E1 cells up-regulated CSF-1 mRNA , and compared to either agent alone , cycloheximide and in combination *resulted* in augmentation of [CSF-1] expression . Positive_regulation CSF1 TNF 8647916 366336 A series of studies using both agonists and inhibitors indicated that *induced* [CSF-1] expression did not involve the arachidonic acid , PKC , or cAMP pathways . Positive_regulation CSF1 TNF 8647916 366338 These results suggest that *induces* [CSF-1] expression in osteoblasts by a transcriptional mechanism which is largely independent of new protein synthesis and of the second messenger pathways examined . Positive_regulation CSF1 TNF 8781564 380387 Incubation of mesangial cells with *stimulated* mRNA expression and protein synthesis of [M-CSF] . Positive_regulation CSF1 TNF 8781564 380389 Preincubation of mesangial cells with calphostin C , a PKC inhibitor , reduced both PMA- and *induced* [M-CSF] mRNA transcripts . Positive_regulation CSF1 TNF 8781564 380390 Specific protein tyrosine kinase inhibitors blocked *induced* mesangial cell [M-CSF] mRNA expression . Positive_regulation CSF1 TNF 8781564 380394 However , coincubation of mesangial cells with TNF-alpha and either dbcAMP , forskolin , or pertussis toxin inhibited *induced* [M-CSF] gene expression . Positive_regulation CSF1 TNF 8914012 395646 The production of macrophage colony stimulating factor ( [M-CSF] ) was stimulated in the *presence* of 1,25 ( OH ) 2D3 ( 50 nM ) , ( 2 ng/ml ) or both in MG-63 cells . Positive_regulation CSF1 TNF 9147389 429755 We hypothesize that [M-CSF] released by astrocytes , upon *stimulation* by lipopolysaccharide (LPS) , or interleukin-1 (IL-1) , regulates the expression of its own receptor . Positive_regulation CSF1R EPHB2 16357167 1492808 Constitutive activation of the extracellular signal regulated kinase ( ERK ) pathway also enhanced PDEF induced motility and invasion , suggesting that *activation* of the activated protein kinase by ErbB2 and [CSF-1R/CSF-1] can cooperate with PDEF to promote motility and invasion . Positive_regulation CSF1R TLR7 18294963 1878662 *induced* [CSF-1 receptor] RIPping is largely independent of protein kinase C , while maximal RIPping depends on Erk activation . Positive_regulation CSF1R TNF 19628784 2137864 [c-Fms] expression in HSCs/promonocytes was mainly *regulated* by derived from BM CD45 ( - ) CD34 ( - ) stromal cells , and Ang II specifically regulated the TNF-alpha synthesis and release from BM stromal cells . Positive_regulation CSF1R TNF 20803546 2345967 also *increased* [c-Fms] expression at both mRNA and protein levels in BMMs . Positive_regulation CSF2 ALOX5 11090070 754418 Granulocyte-macrophage [colony stimulating factor] ( GM-CSF ) plus tumor necrosis factor-alpha (TNF-alpha) promoted DC differentiation and *induced* a strong rise in <5-LO> and FLAP expression . Positive_regulation CSF2 ALOX5 7513312 253702 [GM-CSF] by itself *induced* an increase in <5-lipoxygenase-specific> mRNA expression within 5 min . Positive_regulation CSF2 ALOX5 8283055 247440 [GM-CSF] *induced* a dose- and time dependent de novo synthesis of the <5-LO> in PMNL , as determined by immunoprecipitation of 35S-methionine labeled 5-LO . Positive_regulation CSF2 EDN2 9124553 424016 *stimulates* osteoblastic production of IL-6 but not macrophage [colony stimulating factor] . Positive_regulation CSF2 EPHB2 10378896 623895 In marked contrast to neutrophils and MO7e cells , [GM-CSF] did not *induce* tyrosine phosphorylation and activation of in monocytes . Positive_regulation CSF2 EPHB2 10702314 672660 Granulocyte/macrophage [colony stimulating factor] , interleukin 3 , and TPA , all of which induced macrophage proliferation , also *induced* activity , which was maximal at 5 min poststimulation . Positive_regulation CSF2 EPHB2 12063024 953294 Transient phosphorylation and activation of was *induced* by both [GM-CSF] alone and combination of the two cytokines , whereas sustained phosphorylation and activation was induced only by the combination . Positive_regulation CSF2 EPHB2 12208854 998103 Pharmacological inhibition of Akt or activation in LPS treated tracheal explants ex vivo *inhibited* the release of [GM-CSF] . Positive_regulation CSF2 EPHB2 16106368 1454191 Although IL-10 did not alter *activation* of by [GM-CSF] or TNF-alpha , it did inhibit activation induced by LPS . Positive_regulation CSF2 EPHB2 16491014 1541267 Ro-31-8220 , a PKC inhibitor , and PD98059 , a mitogen activated kinase inhibitor , *suppressed* the histamine induced ERK activation and the production of granulocyte macrophage [colony stimulating factor] and IL-8 . Positive_regulation CSF2 EPHB2 18056041 1833411 signaling *regulates* macrophage [colony stimulating factor] expression induced by titanium particles in MC3T3.E1 murine calvarial preosteoblastic cells . Positive_regulation CSF2 EPHB2 22233535 2564010 The IL-33 induced production of IL-8 and [GM-CSF] from HNECs in vitro was significantly *suppressed* by corticosteroid treatment and distinct signal transduction inhibitors of , p38 MAPK , JNK , NF-?B and epidermal growth factor receptor . Positive_regulation CSF2 F3 3497933 77887 [Colony stimulating factor-1] *induces* activity in murine macrophages and human monocytes . Positive_regulation CSF2 FAS 8870694 389450 Macrophage [colony stimulating factor] ( M-CSF ) , which is present at increased levels in MRL/lpr mice , but not in MRL/Mp- +/+ ( MRL/+ ) mice , *induced* the expression of Mac-2 antigen and antigen on spleen adherent cells of MRL/+ mice . Positive_regulation CSF2 HRH1 15514212 1359726 The present results indicate that HDC and HHR are expressed in arteriosclerotic lesion , and that [GM-CSF] *induces* HDC and expression in monocytes . Positive_regulation CSF2 HRH1 16491014 1541265 *stimulated* interleukin 8 and granulocyte macrophage [colony stimulating factor] production by bronchial epithelial cells requires extracellular signal regulated kinase signaling via protein kinase C . Positive_regulation CSF2 IL1B 10783130 688164 Coincubation with IL-4 or IL-13 dose-dependently inhibited *induced* [GM-CSF] release . Positive_regulation CSF2 IL1B 10783130 688165 This excludes sequences further upstream from a major regulatory role in [GM-CSF] promoter *activation* by or PMA in these cells . Positive_regulation CSF2 IL1B 10903772 713209 TNF-alpha , , and PMA *induced* the release of [GM-CSF] in HBECs . Positive_regulation CSF2 IL1B 10958685 726158 Low concentrations of dexamethasone ( 10 ( -10 ) M ) repress *stimulated* granulocyte-macrophage [colony stimulating factor] ( GM-CSF ) expression and fail to stimulate secretory leukocyte proteinase inhibitor expression . Positive_regulation CSF2 IL1B 11159726 781263 3. The cyclic AMP elevating agents , dibutyryl cyclic AMP ( approximately EC ( 50 ) 135 microM ) , forskolin ( approximately EC ( 50 ) 530 nM ) and cholera toxin ( approximately EC ( 50 ) 575 pg ml(-1) ) abolished *induced* release of [GM-CSF] , RANTES and eotaxin , but not IL-8 . Positive_regulation CSF2 IL1B 11395507 842694 Dexamethasone represses *stimulated* histone acetylation and granulocyte-macrophage [colony stimulating factor] expression through a combination of direct inhibition of p65 associated histone acetyltransferase ( HAT ) activity and by recruiting histone deacetylase 2 (HDAC2) to the p65-HAT complex . Positive_regulation CSF2 IL1B 11395507 842695 Here we show that mifepristone , a glucocorticoid receptor partial agonist , has no ability to induce gene expression but represses *stimulated* histone acetylation and granulocyte-macrophage [colony stimulating factor] release by 50 % maximally . Positive_regulation CSF2 IL1B 11446745 835421 up-regulation is not dependent on PKC but the PKC activator PMA *induces* low levels of [GM-CSF] production and acts synergistically with IL-1beta to further increase GM-CSF . Positive_regulation CSF2 IL1B 11446745 835422 *stimulated* [GM-CSF] mRNA expression and production was strongly dependent on NF-kappaB . Positive_regulation CSF2 IL1B 11520738 852313 In the present study , we examined a requirement for mitogen activated protein (MAP) kinase activation for *stimulated* [GM-CSF] , RANTES , and eotaxin release . Positive_regulation CSF2 IL1B 11698053 877748 The role of histone acetylation and DNA methylation in the transcription of GM-CSF was indicated by trichostatin A (TSA) , an inhibitor of histone deacetylases , and 5-azacytidine ( 5-aza ) , a DNA methylase inhibitor , to increase GM-CSF expression partially blocking glucocorticoid inhibition of *stimulated* [GM-CSF] release . Positive_regulation CSF2 IL1B 11698053 877749 These data suggest that the mechanism of glucocorticoid action in suppressing *stimulated* [GM-CSF] release in A549 cells may involve modulation of CBP mediated histone-acetylase activity and DNA methylation . Positive_regulation CSF2 IL1B 11956032 930888 To determine whether granulocyte [macrophage-colony stimulating factor] ( GM-CSF ) production by neuronal precursor ( NT2 ) cells can be *regulated* by and TNF-alpha . Positive_regulation CSF2 IL1B 11956032 930895 and TNF-alpha both *increase* [GM-CSF] mRNA expression by NT2 cells , but only IL-1beta increases net GM-CSF protein accumulation . Positive_regulation CSF2 IL1B 12114209 964004 After activation for 4 h with tumor necrosis factor (TNF)-alpha ( 30/300 U/ml ) , lipopolysaccharide ( LPS ; 0.1/1 microg/ml ) , or interleukin (IL)-1 beta ( 100 U/ml ) , a significant release of GM-CSF was measured by enzyme linked immunosorbent assay , with a time dependent increase over 72 h . IL-8 ( 4 , 16 , or 64 ng/ml ) or at a concentration of 10 U/ml did not *induce* the release of [GM-CSF] . Positive_regulation CSF2 IL1B 12114209 964005 [GM-CSF] release in HPMEC was significantly ( P < 0.025-0.05 ) less *inducible* by than in HUVEC . Positive_regulation CSF2 IL1B 12127790 966178 We evaluated the constitutive and *induced* expression of [GM-CSF] and TNF-alpha and the expression/activity of NF-kappaB in HPV+ and HPV- cell lines . Positive_regulation CSF2 IL1B 12388337 1031313 treatment *induced* a time dependent induction of [GM-CSF] in HASMC . Positive_regulation CSF2 IL1B 12388337 1031314 Exposure of HASMC to CO at low concentration ( 250 ppm ) markedly inhibited *induced* [GM-CSF] synthesis ( > 90 % ) compared with air treated controls . Positive_regulation CSF2 IL1B 12406856 1031642 and CSM *increased* IL-8 and [GM-CSF] release by macrophages from both smokers and patients with COPD . Positive_regulation CSF2 IL1B 12406856 1031644 In contrast , basal and *stimulated* [GM-CSF] release , but not CSM stimulated release , was inhibited by dexamethasone . Positive_regulation CSF2 IL1B 12744771 1088516 [GM-CSF] *induction* in human lung fibroblasts by , TNF-alpha , and macrophage contact . Positive_regulation CSF2 IL1B 12744771 1088518 Both and TNF-alpha significantly *enhanced* the production of [GM-CSF] by NHLF . Positive_regulation CSF2 IL1B 12746045 1088641 Stimulation with TNF-alpha or *increased* the MIP-1alpha and GM-CSF release from AM of normal controls and patients with pneumonia and interstitial lung disease : however , no further enhancement of MIP-1alpha and [GM-CSF] production was observed in AM from sarcoidosis patients . Positive_regulation CSF2 IL1B 12871843 1112575 2. We examined the role of the mitogen activated protein kinase (MAPK) c-jun N-terminal kinase ( JNK ) in TNFalpha- and *induced* [GM-CSF] , RANTES and IL-8 production in HASMC by using a novel specific inhibitor for JNK ( SP600125 ) . Positive_regulation CSF2 IL1B 12871843 1112576 5. JNK activation is involved in TNFalpha- and *induced* [GM-CSF] , RANTES and IL-8 production from HASMC . Positive_regulation CSF2 IL1B 1381374 196061 *stimulates* [colony stimulating factor-1] production in placental villous core mesenchymal cells . Positive_regulation CSF2 IL1B 1444189 205129 [GM-CSF] as well as D3 and IFN-gamma *induced* production by the HL-60 cells , clearly indicating their importance in differentiation of these cells . Positive_regulation CSF2 IL1B 14586044 1159420 Resveratrol reduced *stimulated* IL-8 and [GM-CSF] release in both smokers and COPD patients to below basal levels . Positive_regulation CSF2 IL1B 1478679 207506 Expression and generation of interleukin-8 , IL-6 and granulocyte-macrophage [colony stimulating factor] by bronchial epithelial cells and *enhancement* by and tumour necrosis factor-alpha . Positive_regulation CSF2 IL1B 14998300 1216620 15-Deoxy-delta ( 12,14 ) -prostaglandin J2 inhibits the *induced* expression of granulocyte-macrophage [colony stimulating factor] in BEAS-2B bronchial epithelial cells . Positive_regulation CSF2 IL1B 14998300 1216621 *stimulated* the expression of [GM-CSF] in BEAS-2B cells in concentration- and time dependent manners . Positive_regulation CSF2 IL1B 14998300 1216622 When the cells were pretreated with 15d-PGJ2 for 1 hour , the *induced* [GM-CSF] expression was inhibited in a concentration dependent manner ( 2-50 microM ) . Positive_regulation CSF2 IL1B 14998300 1216623 Ciglitazone , another agonist of PPAR-gamma , did not affect the *induced* [GM-CSF] expression in BEAS-2B cells . Positive_regulation CSF2 IL1B 15023863 1228083 1. The prostanoid receptor ( s ) on human airways smooth muscle ( HASM ) cells that mediates the inhibitory effect of PGE ( 2 ) on *induced* granulocyte/macrophage [colony stimulating factor] ( GM-CSF ) release has been classified . Positive_regulation CSF2 IL1B 15388258 1300331 While a wide range of doses of IL-17 or IL-17F alone did not induce GM-CSF release from LMVECs , IL-17 had an enhancing effect on macrophage derived IL-1beta- and TNF-alpha induced GM-CSF mRNA expression and production , whereas IL-17F had an enhancing effect on *induced* [GM-CSF] production , but a marked inhibitory effect on TNF-alpha induced secretion . Positive_regulation CSF2 IL1B 15455248 1374727 In the [CSF] , the level *increased* from 55.71+/-72.79 pg/ml at T1 to 106.10+/-142.12 pg/ml at T2 and the IL-6 level increased from 405.43+/-280.28 pg/ml at T1 to 631.57+/-385.35 pg/ml at T2 ; Positive_regulation CSF2 IL1B 15699160 1372503 *dependent* release of eotaxin , RANTES , and [GM-CSF] was enhanced by fibronectin and by fibrillar and monomeric type I collagen , with similar changes in mRNA abundance . Positive_regulation CSF2 IL1B 16380507 1512630 Specific knockdown of HDAC2 by RNA interference resulted in reduced sensitivity to dexamethasone suppression of *induced* granulocyte/macrophage [colony stimulating factor] production . Positive_regulation CSF2 IL1B 16529829 1555148 Globular adiponectin doubled *stimulated* IL-8 and [GM-CSF] secretion . Positive_regulation CSF2 IL1B 16847181 1588127 The messenger RNA expressions of LARC ( liver and activation regulated chemokine ) , [GMCSF] ( granulocyte-macrophage colony stimulating factor ) , epiregulin , ICAM1 ( intercellular adhesion molecule 1 ) , and TGFA ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation CSF2 IL1B 17077666 1642379 *enhanced* the mRNA and/or protein levels of granulocyte-macrophage [colony stimulating factor] ( GM-CSF ) , IL-8 , and monocyte chemotactic protein (MCP)-1 in HCE and IL-6 , IL-8 , MCP-3 , and regulated on T-cell activation expressed secreted ( RANTES ) in HCFs . Positive_regulation CSF2 IL1B 17470620 1737612 However , histamine increased *induced* [GM-CSF] release and markedly reduced TNF-alpha induced RANTES release by both asthmatic and nonasthmatic cells to a similar extent , but did not modulate PGE ( 2 ) release . Positive_regulation CSF2 IL1B 1790636 176091 But [GM-CSF] did not *induce* the production of . Positive_regulation CSF2 IL1B 19435930 2107012 Knockdown of TTP protein by siRNA elevated *induced* expression of granulocyte macrophage-colony stimulating factor ( [GM-CSF] ) and IL-8 , demonstrating a role for TTP in feedback control . Positive_regulation CSF2 IL1B 19435930 2107014 Likewise , knockdown of TTP increased [GM-CSF] expression in the *presence* of plus dexamethasone , suggesting that feedback control by TTP also occurs in the context of IL-1beta plus dexamethasone . Positive_regulation CSF2 IL1B 20100175 2219232 Glucocorticoids inhibit *induced* [GM-CSF] expression at multiple levels : roles for the ERK pathway and repression by MKP-1 . Positive_regulation CSF2 IL1B 20100175 2219233 At 2 h , *induced* expression of [GM-CSF] protein , but not mRNA , was sensitive to the MEK [ MAPK ( mitogen activated protein kinase ) /ERK ( extracellular-signal regulated kinase ) kinase ] inhibitors PD098059 and U0126 . Positive_regulation CSF2 IL1B 2012180 156679 In addition , and TNF-alpha *induced* high levels of granulocyte-macrophage colony stimulating factor ( [GM-CSF] ) and macrophage colony stimulating factor ( M-CSF ) mRNAs . Positive_regulation CSF2 IL1B 2026869 157468 Both and TNF-alpha *induced* [GM-CSF] mRNA accumulation , with a maximum effect after 4 h of stimulation . Positive_regulation CSF2 IL1B 2026869 157471 After 1 wk in culture , additional stimulation with or TNF-alpha was *required* for [GM-CSF] production . Positive_regulation CSF2 IL1B 2204769 140756 Response of murine cell lines to an IL-1/IL-2 induced factor in a rat/mouse T hybridoma ( PC60 ) : differential *induction* of cytokines by human IL-1 alpha and and partial amino acid sequence of rat [GM-CSF] . Positive_regulation CSF2 IL1B 22517618 2618472 Here we demonstrate that significantly *increased* the expression and release of interleukin-8 ( CXCL8 ) , monocyte chemotactic protein-1 ( CCL2 ) , and granulocyte macrophage colony stimulating factor ( [CSF2] ) by primary human myometrial cells . Positive_regulation CSF2 IL1B 22517618 2618475 Using selective EP receptor agonists and a selective EP(4) antagonist , we show that PGE ( 2 ) mediates the repression of *induced* release of CXCL8 , CCL2 , and [CSF2] via activation of the EP(2) and EP(4) receptors . Positive_regulation CSF2 IL1B 2265245 147228 Heated *caused* an increase of neither IL-6 nor [CSF] activities . Positive_regulation CSF2 IL1B 2476327 116968 The expression of granulocyte-macrophage [colony stimulating factor] ( GM-CSF ) and granulocyte colony stimulating factor ( G-CSF ) genes by stromal cells of the hematopoietic microenvironment is *regulated* , in vitro , by interleukin 1 alpha (IL-1 alpha) and . Positive_regulation CSF2 IL1B 2665849 115999 Thus , in this particular case , endogenously produced had *stimulated* the release of [GM-CSF] which resulted in GM-CSF dependent proliferation . Positive_regulation CSF2 IL1B 7789482 313119 [GM-CSF] concentrations *increased* following stimulation with and H2O2 , and the effect of IL-1 beta/H2O2 co-stimulation on GM-CSF concentrations was additive . Positive_regulation CSF2 IL1B 8019788 262812 Stimulation of the cells with *caused* a marked increase of [GM-CSF] , IL-8 , IL-6 and as well as of M-CSF mRNA levels . Positive_regulation CSF2 IL1B 8301137 248690 [Macrophage-colony stimulating factor] expression by anti-CD45 stimulated human monocytes is transcriptionally *up-regulated* by and inhibited by IL-4 and IL-10 . Positive_regulation CSF2 IL1B 8445029 213748 *stimulates* [colony stimulating factor-1] production in human term placenta . Positive_regulation CSF2 IL1B 8576941 340901 Vesnarinone [ OPC-8212 ; 3,4-dihydro-6- ( 4- ( 3,4-dimethoxybenzoil ) -1-piperazinyl ) -2 ( 1H ) - quinolinone ] at 26 mumol/l significantly suppressed the production of IL-6 , granulocyte macrophage [colony stimulating factor] ( GM-CSF ) and granulocyte colony stimulating factor ( G-CSF ) *induced* by . Positive_regulation CSF2 IL1B 8591999 350631 Several lines of evidence suggest that the biologic effects of are *mediated* by activation of type I IL-1 receptors ( IL-1RI ) and induction of [GM-CSF] production . Positive_regulation CSF2 IL1B 8601605 351911 Interleukin-1 beta up-regulated GM-CSF production thus suggesting that injury induced [GM-CSF] production may be *mediated* by . Positive_regulation CSF2 IL1B 8707349 371191 Production of granulocyte-macrophage [colony stimulating factor] by T cells is *regulated* by B7 and . Positive_regulation CSF2 IL1B 8780161 380046 After 24 hours , contact allergens not only increased the expression of but also *induced* the expression of IL-1 alpha , TNF-alpha , [GM-CSF] , and IL-6 proteins mainly by suprabasal keratinocytes . Positive_regulation CSF2 IL1B 9365094 463083 However , the secretion of IL-6 , IL-8 , and [GM-CSF] stimulated by the complexes was not completely *dependent* upon the secretion of . Positive_regulation CSF2 IL1B 9626137 511767 In 4 of 14 samples , also *stimulated* secretion of granulocyte-macrophage [colony stimulating factor] . Positive_regulation CSF2 IL1B 9652398 515854 However , in these cells , *induction* of inducible nitric oxide synthase , granulocyte-macrophage [colony stimulating factor] and cyclooxygenase-2 mRNA showed 70-90 % repression by dexamethsone . Positive_regulation CSF2 IL1B 9700099 525183 stimulation *resulted* in a 15-fold induction of [GM-CSF] protein , which was associated with a corresponding 47-fold maximal induction of GM-CSF mRNA levels . Positive_regulation CSF2 IL1B 9700099 525184 Taken together , these data demonstrate that *induction* of [GM-CSF] is mediated through transcriptional mechanisms . Positive_regulation CSF2 IL1B 9818659 546922 *increased* the production of IL-6 and [GMCSF] by mock infected and infected cells . Positive_regulation CSF2 IL1B 9832332 551719 Increasing cyclic adenosine nucleotide ( cAMP ) levels suppressed *induced* increases in [GMCSF] mRNA levels . Positive_regulation CSF2 IL1B 9832332 551720 In contrast , botulinum toxin C , which mediates the ADP ribosylation of a 21 kD ras related G protein , augmented *induced* [GMCSF] mRNA expression . Positive_regulation CSF2 IL1B 9832332 551722 Finally , disruption of either microtubules ( with colchicine ) or microfilaments ( with cytochalasin B ) resulted in reduced [GMCSF] mRNA expression in *response* to . Positive_regulation CSF2 IL1B 9843925 553653 [GM-CSF] levels in culture medium from smooth muscle cells were markedly *increased* by and were maximum at 30 ng/ml ( 0.037 ng/ml/10 ( 6 ) cells versus 3.561 ng/ml/10 ( 6 ) cells , unstimulated versus 30 ng/ml IL-1beta ) . Positive_regulation CSF2 IL6R 10671302 666721 The objective of this study was to investigate the pathophysiological *roles* of soluble ( sIL-6R ) in [cerebrospinal fluid (CSF)] . Positive_regulation CSF2 ITGAL 10556811 566009 The results indicate that : ( 1 ) GM-CSF can prime monocytes for increased TEM , ( 2 ) [GM-CSF] enhances LFA-1 mediated monocyte TEM and ( 3 ) this effect is in part *mediated* by increasing expression and activation . Positive_regulation CSF2 ITGB2 12600815 1098992 IL-3 , IL-5 , and [GM-CSF] could enhance p38 MAPK and NF-kappaB activity and *induce* ICAM-1 , CD11b , and expressions on eosinophils . Positive_regulation CSF2 ITGB2 14613935 1187971 Co-stimulating and CD11b with activating antibodies *resulted* in NF-kappaB activation by [GM-CSF] and IL-8 in suspended cells . Positive_regulation CSF2 ITGB2 15710475 1373504 Using the markers Mac1 ( + ) /CD45 ( low ) and Mac1 ( + ) /CD45 ( high ) to define microglia and macrophages , respectively , we show that ( + ) cells are *induced* by [GM-CSF] stimulation following neuronal differentiation of mouse ES cells using a five-step method . Positive_regulation CSF2 ITGB2 2428876 62855 [GM-CSF] stimulation of HL-60 cells *induced* a similar and p150 ,95 phenotype . Positive_regulation CSF2 JAG1 11441110 833431 Both sequentially *stimulated* phosphoinositide hydrolysis , transient cytosolic Ca ( 2+ ) mobilization , and release of [GM-CSF] and eotaxin in human pulmonary epithelial cells . Positive_regulation CSF2 MAP2K6 10775036 686486 In contrast , treatment of TF-1a cells with [granulocyte/macrophage-colony stimulating factor] induced only transient *activation* of and p44/42 MAPK ( 10-20 min ) and an increase ( approximately 50 % ) in cell proliferation , without any change in cellular differentiation . Positive_regulation CSF2 MAP2K6 15316530 1286279 Selective inhibitors , PD98059 and U0126 , and Raf1 kinase inhibitor I significantly *inhibited* ML-1 induced [GM-CSF] production . Positive_regulation CSF2 MAP2K6 19823673 2148917 This identifies a novel role for *mediated* [cytostatic factor (CSF)] activity during meiosis in membrane protein trafficking in mouse oocytes , and shows for the first time that selective retrieval of membrane proteins is a feature of meiosis in mammalian oocytes . Positive_regulation CSF2 MAP2K6 9864179 582689 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of ERK , but not p38 MAPK , induced by G-CSF , [GM-CSF] , or TNF . Positive_regulation CSF2 MMP7 18252806 1895827 TNF-alpha *induces* the expression of transcripts for inflammatory mediators interleukin (IL)-6 , IL-8 , regulated on activation normal T cell expressed and secreted , TNF-alpha , granulocyte macrophage-colony stimulating factor ( [GM-CSF] ) , and monocyte chemoattractant protein (MCP)-1 and also invasion mediators , MMP-9 , and intracellular adhesion molecule-1 . Positive_regulation CSF2 PLAU 15885322 1406800 To evaluate the potential role of the uPAR/uPA/PAI-1 system in HIV induced blood-brain-barrier ( BBB ) disruption , [CSF] *dependent* plasminogen activation ( PdPA ) was analyzed by casein zymography , and CSF protein levels of all three molecules were measured by ELISA . Positive_regulation CSF2 S100B 19132530 2079110 does not *increase* in [CSF] of septic patients ; Positive_regulation CSF2 SELL 18619508 1947390 In our previous studies , we reported that ligation could *increase* macrophage [colony stimulating factor (CSF)-1] gene transcription , in which c-Abl acts as a crucial cytoplasmic kinase . Positive_regulation CSF2 STAT4 9422769 481395 Furthermore , [GM-CSF] *induced* the tyrosine phosphorylation of STAT3 and STAT5 but not of STAT1 , STAT2 , , or STAT6 . Positive_regulation CSF2 SYT8 8962603 366102 A marked reduction in synaptotagmin was found both in the hippocampus and frontal cortex of EAD , suggesting that a decrease in in the brain is *followed* by a concomitant decrease in the [CSF] . Positive_regulation CSF2 TLR7 15880118 1411397 CD1b+ dendritic cells were expanded by *mediated* upregulation of granulocyte-macrophage colony stimulating factor ( [GM-CSF] ) and its receptor , promoted T cell activation and secreted proinflammatory cytokines . Positive_regulation CSF2 TLR7 19094116 2036069 In CD patients , *induced* [GM-CSF] secretion was impaired by both NOD2 dependent and -independent mechanisms . Positive_regulation CSF2 TMEM100 19641137 2124687 [GM-CSF] *induced* the expression of dendritic cell-specific ( DC-STAMP ) , which was mediated by inducing NFATc1 via induction of c-Fos . Positive_regulation CSF2 TMEM156 19641137 2124705 [GM-CSF] *induced* the expression of dendritic cell-specific ( DC-STAMP ) , which was mediated by inducing NFATc1 via induction of c-Fos . Positive_regulation CSF2 TMEM211 19641137 2124785 [GM-CSF] *induced* the expression of dendritic cell-specific ( DC-STAMP ) , which was mediated by inducing NFATc1 via induction of c-Fos . Positive_regulation CSF2 TMEM213 19641137 2124722 [GM-CSF] *induced* the expression of dendritic cell-specific ( DC-STAMP ) , which was mediated by inducing NFATc1 via induction of c-Fos . Positive_regulation CSF2 TNF 10199558 605268 We show here that *increases* the production of both soluble ( sMCSF ) and membrane bound ( mMCSF ) macrophage [colony stimulating factor] by ST2 bone stromal cells . Positive_regulation CSF2 TNF 10385526 625565 We show that A20 does not inhibit TNF- induced nuclear translocation and DNA binding of NF-kappaB , although it completely prevents the *induced* activation of an NF-kappaB dependent reporter gene , as well as TNF induced IL-6 and granulocyte [macrophage-colony stimulating factor] gene expression . Positive_regulation CSF2 TNF 10476324 642724 [GM-CSF] transcripts , but not the other cytokines , were present in unstimulated epithelial cells , and levels were *increased* with stimulation . Positive_regulation CSF2 TNF 10476324 642725 stimulation *increased* the levels of [GM-CSF] and PGE2 in epithelial cell supernatants and dexamethasone suppressed the TNF-alpha induced increases . Positive_regulation CSF2 TNF 10562301 567020 IL-18 independently promoted [GM-CSF] and nitric oxide production , and it *induced* significant synthesis by CD14 ( + ) macrophages in synovial cultures ; Positive_regulation CSF2 TNF 10764146 683991 Both [GM-CSF] and TNF induced caspase 3-like activity in this cell line though the time course was distinct between two cytokines , and combined stimulation of cells with GM-CSF plus *induced* additive or synergistic activation of caspase 3-like activity . Positive_regulation CSF2 TNF 10768935 685063 IL-8 , IL-1alpha , IL-1beta , MCP-1 , GM-CSF , and mRNA expression *increased* within 1 h postinfection , reached a maximum after 3 to 4 h , and then declined to preinfection levels within 3 h . IL-8 , MCP-1 , and [GM-CSF] were secreted by HeLa cells , whereas IL-1alpha and IL-1beta were not secreted and thus were found exclusively intracellularly . Positive_regulation CSF2 TNF 10799531 691223 We show both here and previously that mutation of any one of these binding sites greatly reduces *induction* of the [GM-CSF] promoter . Positive_regulation CSF2 TNF 10822085 694697 *induced* expression of both IL-8 and [GM-CSF] , without detectable production of RANTES . Positive_regulation CSF2 TNF 10843757 700325 *induced* [GM-CSF] release in PC60 R55/R75 cells was enhanced by nigericin or ouabain . Positive_regulation CSF2 TNF 10903772 713208 , IL-1beta , and PMA *induced* the release of [GM-CSF] in HBECs . Positive_regulation CSF2 TNF 10903772 713211 PMA induced GM-CSF production in HBECs did not require a Ca2+ ionophore and was not inhibited by cyclosporin A. Activation of MAPKerk1/2 via PKC was associated with and was required for [GM-CSF] production *induced* by PMA and . Positive_regulation CSF2 TNF 10919279 717224 Nuclear factor-kappaB p50 is required for *induced* [colony stimulating factor-1] gene expression in osteoblasts . Positive_regulation CSF2 TNF 11008013 735739 Supporting this notion , *induced* upregulation of [GM-CSF] mRNA levels and protein secretion in the TNF-alpha-proliferative , but not in the TNF-alpha-apoptotic cell lines . Positive_regulation CSF2 TNF 11108836 757033 *induces* osteoclast differentiation from bone marrow cells in the presence of macrophage [colony stimulating factor] . Positive_regulation CSF2 TNF 11509005 848225 Furthermore , *induced* [GM-CSF] release from eosinophils . Positive_regulation CSF2 TNF 11550977 856946 The [ 125I ] [-GM-CSF] binding to the cells was slightly *increased* with phorbol 12-myristate 13-acetate ( PMA ) , insulin-like growth factor-I , platelet derived growth factor , basic fibroblast growth factor , and , and decreased with pertussis toxin , cholera toxin , and interleukin-1beta . Positive_regulation CSF2 TNF 11588035 866576 Finally , the results showed that TNFR1 plays an important role in mediating *induced* changes in TNF-alpha and [GM-CSF] mRNA stability . Positive_regulation CSF2 TNF 11683958 875702 Bone marrow haematopoietic cell derived DC ( BM-DC ) were generated using granulocyte-macrophage [colony stimulating factor] ( GM-CSF ) in the *presence* or absence of . Positive_regulation CSF2 TNF 11956032 930887 To determine whether granulocyte [macrophage-colony stimulating factor] ( GM-CSF ) production by neuronal precursor ( NT2 ) cells can be *regulated* by IL-1beta and . Positive_regulation CSF2 TNF 11956032 930893 *increased* [GM-CSF] mRNA expression to a lesser extent than did IL-1beta ( maximal stimulation at 200 U/ml ) , and a minimal increase in net protein accumulation was noted . Positive_regulation CSF2 TNF 11956032 930894 IL-1beta and both *increase* [GM-CSF] mRNA expression by NT2 cells , but only IL-1beta increases net GM-CSF protein accumulation . Positive_regulation CSF2 TNF 12648514 1070437 We have shown recently that these seemingly contradictory effects are based on the divergent capacities of the cells to produce granulocyte-macrophage [colony stimulating factor] ( GM-CSF ) upon *stimulation* with . Positive_regulation CSF2 TNF 12744771 1088515 [GM-CSF] *induction* in human lung fibroblasts by IL-1beta , , and macrophage contact . Positive_regulation CSF2 TNF 12744771 1088517 Both IL-1beta and significantly *enhanced* the production of [GM-CSF] by NHLF . Positive_regulation CSF2 TNF 12746045 1088640 Stimulation with or IL-1beta *increased* the MIP-1alpha and GM-CSF release from AM of normal controls and patients with pneumonia and interstitial lung disease : however , no further enhancement of MIP-1alpha and [GM-CSF] production was observed in AM from sarcoidosis patients . Positive_regulation CSF2 TNF 1328463 197834 The mediated *induction* of granulocyte/macrophage [colony stimulating factor] was strongly synergized by the addition of interleukin 1 . Positive_regulation CSF2 TNF 14509560 1146402 HBECs , freshly isolated from resected bronchi at the time of surgery in ex-smokers with lung cancer , constitutively expressed over 3 times more ICAM-1 than VCAM-1 ( P < 0.05 ) and secreted greater amounts of IL-8 than of GM-CSF or RANTES ( P < 0.001 ) . Stimulation of HBECs with IL-4 , TNF-alpha or IL-4 plus TNF-alpha upregulated ICAM-1 expression ( P < 0.05 ) and increased [GM-CSF] and IL-8 secretion ( P < 0.05 ) . Similarly , VCAM-1 expression was significantly *increased* by IL-4 plus , while RANTES release was significantly enhanced by IL-4 or by IL-4 plus TNF-alpha ( P < 0.05 ) , but not by TNF-alpha alone ( P > 0.05 ) . Positive_regulation CSF2 TNF 14551160 1218549 Erythromycin , clarithromycin , azithromycin , and dexamethasone inhibited *induced* [GM-CSF] expression in A549 cells at both the protein and messenger RNA levels . Positive_regulation CSF2 TNF 15021978 1221915 KF19514 , a phosphodiesterase 4 and 1 inhibitor , inhibits *induced* [GM-CSF] production by a human bronchial epithelial cell line via inhibition of PDE4 . Positive_regulation CSF2 TNF 15021978 1221922 These results indicate that KF19514 and PDE4 inhibitors reduce *induced* [GM-CSF] production of BEAS-2B cells via a cAMP dependent pathway . Positive_regulation CSF2 TNF 1503080 193762 Thus , in these cases , constitutively produced IL-1 or had *stimulated* the synthesis of [GM-CSF] , which resulted in GM-CSF dependent proliferation of AML blasts . Positive_regulation CSF2 TNF 15208591 1261749 Glucocorticoid receptor nuclear translocation was determined in PBMCs by immunocytochemistry and GR function measured by suppression of *induced* [GM-CSF] release and effects of dexamethasone on histone acetylation . Positive_regulation CSF2 TNF 15208591 1261750 Glucocorticoid repression of *induced* [GM-CSF] release was reduced in PBMCs from SD and SR patients . Positive_regulation CSF2 TNF 15211029 1262154 We observed constitutive expression of interleukin (IL)-6 , IL-8 , granulocyte macrophage colony stimulating factor ( [GM-CSF] ) , and monocyte chemoattractant protein (MCP)-1 in both human and baboon endothelial cells , and these cytokines were further *induced* by and LPS . Positive_regulation CSF2 TNF 15388258 1300329 While a wide range of doses of IL-17 or IL-17F alone did not induce GM-CSF release from LMVECs , IL-17 had an enhancing effect on macrophage derived IL-1beta- and *induced* [GM-CSF] mRNA expression and production , whereas IL-17F had an enhancing effect on IL-1beta induced GM-CSF production , but a marked inhibitory effect on TNF-alpha induced secretion . Positive_regulation CSF2 TNF 15388258 1300333 Additionally , when Th1 or Th2 cytokine was combined with IL-1beta or TNF-alpha , both Th1 and Th2 cytokines had a modest stimulatory effect on *induced* [GM-CSF] production , whereas IL-4 and IFN-gamma profoundly attenuated IL-1beta induced secretion . Positive_regulation CSF2 TNF 15627642 1349322 Neutralizing ( 100 % ) rabbit anti-mouse interleukin-1 (IL-1) polyclonal antibody did not affect the Mtb30 induced CSF production , indicating it to be IL-1 independent ; whereas , [CSF] production was partly *dependent* on , as goat anti-mouse TNF-alpha immunoglobulin G only partly inhibited it . Positive_regulation CSF2 TNF 15723090 1396080 Similarly , IKK beta ( KA ) and I kappa B alpha delta N overexpression also inhibited IL-1beta- and *dependent* increases in ICAM-1 , IL-8 and [GM-CSF] in addition to IL-1beta mediated increases in cyclooxygenase-2 expression , whereas IKK alpha ( KM ) overexpression had little effect on these outputs . Positive_regulation CSF2 TNF 16006772 1447357 The levels of circulating interleukin (IL)-6 , IL-8 , macrophage [colony stimulating factor] ( M-CSF ) and interleukin 1 receptor antagonist ( IL-1ra ) significantly *increased* with the clinical stage of CRC , and the levels of IL-6 , soluble tumor necrosis factor ( sTNF ) receptor type I ( RI ) , soluble interleukin 2 receptor alpha and with tumor grade , while IL-6 , IL-8 , M-CSF , IL-1ra and sTNF RI levels significantly rose with bowel wall invasion . Positive_regulation CSF2 TNF 16143885 1451522 IL-17 selectively enhanced *induced* G- and [GM-CSF] release . Positive_regulation CSF2 TNF 16143885 1451526 IL-17 augments *induced* G- and [GM-CSF] release via transcriptional and posttranscriptional mechanisms . Positive_regulation CSF2 TNF 1623556 191521 Production of macrophage [colony stimulating factor] ( M-CSF ) by human monocytes is differentially *regulated* by GM-CSF , , and IFN-gamma . Positive_regulation CSF2 TNF 1651781 164354 This study shows the in vitro effect of LiCl on the *induced* or interleukin 1 (IL-1) induced expression of IL-6 , granulocyte-macrophage colony stimulating factor ( [GM-CSF] ) , IL-3 , IL-2 , and the IL-2 receptor-alpha ( IL-2R alpha ) . Positive_regulation CSF2 TNF 1651781 164367 alone *induced* only [GM-CSF] production in these cells , but in the presence of LiCl , increased amounts of GM-CSF as well as small amounts of IL-2 and IL-6 could be detected . Positive_regulation CSF2 TNF 16522458 1531296 Moreover , IL-17E and synergistically *induced* [GM-CSF] and CXCL-8 mRNA . Positive_regulation CSF2 TNF 16704300 1560677 [GM-CSF] was required for the induction of TNF-alpha by SCG , and in turn , *enhanced* the release of GM-CSF and thereby augmented the induction of IL-12p70 and IFN-gamma by SCG . Positive_regulation CSF2 TNF 16734568 1566214 Human periodontal ligament cells secrete macrophage [colony stimulating factor] in *response* to in vitro . Positive_regulation CSF2 TNF 1700731 143347 Cytokine regulation of colony stimulating factor production in cultured human synovial fibroblasts : I. *Induction* of [GM-CSF] and G-CSF production by interleukin-1 and . Positive_regulation CSF2 TNF 1700731 143402 The transcription inhibitor , actinomycin D , and protein synthesis inhibitor , cycloheximide , inhibited the increase in [GM-CSF] and G-CSF production *induced* by IL-1 and . Positive_regulation CSF2 TNF 1705566 152962 The effect does not occur at 0 degrees C and can not be *induced* by IL-2 , IL-6 , or [GM-CSF] . Positive_regulation CSF2 TNF 1714478 163509 Results obtained by Northern analysis of chondrocyte total RNA reflected those found for the CSF Ag , namely that [CSF] mRNA levels were elevated in *response* to IL-1 , but not , and that there was synergy between these two cytokines . Positive_regulation CSF2 TNF 18252806 1895860 Interestingly , MEK , p38 , and IKK inhibitors block *induced* IL-8 , IL-6 , and [GM-CSF] secretion and 12z invasion , whereas the PI3K inhibitors do not . Positive_regulation CSF2 TNF 19091594 2031048 Interestingly , we observed that *induced* expression of IL-6 , CXCL1 and granulocyte macrophage colony stimulating factor ( [GM-CSF] ) were significantly enhanced in TRAF6-deficient MEFs . Positive_regulation CSF2 TNF 1912581 167576 Involvement of a nuclear factor-kappa B-like protein in *induction* of the macrophage [colony stimulating factor] gene by . Positive_regulation CSF2 TNF 1915559 168205 Using neutralizing antibodies to tumor necrosis factor (TNF)-alpha we demonstrated that [GM-CSF] production in RA synovial cell cultures is *dependent* on the continued presence of active . Positive_regulation CSF2 TNF 19180992 2007114 Treatment of NECs with EP at more than 25 ng/ml , reduced the ability of NECs to produce [GM-CSF] in *response* to stimulation . Positive_regulation CSF2 TNF 19590023 2130056 Collectively , these findings indicate that released from activated resident alveolar macrophages *induces* epithelial [GM-CSF] expression , which in turn initiates AEC proliferation and contributes to restoring alveolar barrier function . Positive_regulation CSF2 TNF 19850966 2170293 *induced* [GM-CSF] release from human airway smooth muscle cells depends on activation of an ET-1 autoregulatory positive feedback mechanism . Positive_regulation CSF2 TNF 19850966 2170294 ET-1 and granulocyte-macrophage colony stimulating factor ( [GM-CSF] ) expression in *response* to and ET-1 stimulation was investigated , and the impact of mitogen activated protein kinase (MAPK) pathways in this context was studied . Positive_regulation CSF2 TNF 19850966 2170304 ET-1- and *induced* [GM-CSF] expression were both reduced by bosentan as well as by specific inhibition of either ET ( A ) R , ET ( B ) R , p38 ( MAPK ) or ERK-1/-2 . Positive_regulation CSF2 TNF 2012180 156678 In addition , IL-1 beta and *induced* high levels of granulocyte-macrophage colony stimulating factor ( GM-CSF ) and macrophage [colony stimulating factor] ( M-CSF ) mRNAs . Positive_regulation CSF2 TNF 2026869 157462 IL-1 and *had* a synergistic effect on [GM-CSF] production . Positive_regulation CSF2 TNF 2026869 157467 Both IL-1 beta and *induced* [GM-CSF] mRNA accumulation , with a maximum effect after 4 h of stimulation . Positive_regulation CSF2 TNF 2026869 157470 After 1 wk in culture , additional stimulation with IL-1 beta or was *required* for [GM-CSF] production . Positive_regulation CSF2 TNF 20435921 2288105 TBP and TNF-SHARC dose-dependently inhibited *induced* secretion of interleukin (IL)-6 , IL-8 , granulocyte [macrophage-colony stimulating factor] , and monocyte chemoattractant protein-1 in immortalized human endometriotic cells . Positive_regulation CSF2 TNF 20829438 2342205 Moreover , both and interleukin-1 ß , cytokines that are implicated in the genesis of preeclampsia , markedly *up-regulated* granulocyte-macrophage [colony stimulating factor] production in cultured first-trimester human decidual cells . Positive_regulation CSF2 TNF 20956574 2369351 This effect was mediated by [GM-CSF] , which *induced* production by monocytes , which in turn induced MMP-9 in these cells . Positive_regulation CSF2 TNF 21071440 2371310 *induces* expression of granulocyte-macrophage [colony stimulating factor] ( GM-CSF ) but lymphotoxin ß ( LTß ) does not . Positive_regulation CSF2 TNF 21071440 2371311 Here we report that priming of cells with agonistic LTß receptor antibody synergistically enhanced *induced* [GM-CSF] expression . Positive_regulation CSF2 TNF 21071440 2371314 Taken together , these findings suggested that LTß signaling amplified *mediated* [GM-CSF] expression by facilitating chromatin access and the co-recruitment of RNA polymerase II to increase gene transcription . Positive_regulation CSF2 TNF 21145890 2378095 As we found that levels of ( TNF-a ) *increased* in [cerebrospinal fluid (CSF)] and in DRG tissue after L5-VRT , we tested whether the increased TNF-a might result in the changes in sodium channels . Positive_regulation CSF2 TNF 21597760 345771 *induces* [gm-csf] secretion in leukemic-cell lines u-937 and kg-1a . Positive_regulation CSF2 TNF 21597760 345773 Recently it has been shown that IL-1 and can *induce* [GM-CSF] production in fresh leukemic cells of patients who do not release GM-CSF spontaneously . Positive_regulation CSF2 TNF 21597760 345776 To further characterize this phenomenon we investigated [GM-CSF] *induction* by in two leukemic cell lines , U 937 and KG-1a . Positive_regulation CSF2 TNF 22452977 2588630 Evaluation of roflumilast ( 1-10 µM ) showed no significant inhibition alone on TGFß1 induced ET-1 and CTGF mRNA transcripts , ET-1 and FN protein production , alpha smooth muscle expression , or *induced* secretion of CXCL10 , CCL5 and [GM-CSF] . Positive_regulation CSF2 TNF 2460533 98574 and tumor necrosis factor-beta ( lymphotoxin ) *stimulate* the production of granulocyte-macrophage [colony stimulating factor] , macrophage colony stimulating factor , and IL-1 in vivo . Positive_regulation CSF2 TNF 2460533 98578 Using Northern blot analysis to detect tissue levels of hematopoietic growth factor-specific transcripts , and specific biologic and immunologic assays to detect the presence of colony stimulating factors in the serum , we have found that and TNF-beta *induce* the transcription and production of [granulocyte-macrophage-CSF] , macrophage-CSF , and IL-1 . Positive_regulation CSF2 TNF 2473121 113846 Although [GM-CSF] potently *induced* gene transcription by 20 h of treatment , PGE2 interfered with translation into the secreted TNF-alpha protein . Positive_regulation CSF2 TNF 2504305 115255 Mesenchymal cells produce abundant [GM-CSF] in *response* to . Positive_regulation CSF2 TNF 2788173 116796 *induces* [CSF] production by endothelial cells and may therefore provide a paracrine loop to support leukemia growth . Positive_regulation CSF2 TNF 2847661 100355 O2- was *induced* by M-GRAM , TNF , and [GM-CSF] , whereas H2O2 production was significantly stimulated only by M-GRAM and , as shown by functional and ultrastructural assays . Positive_regulation CSF2 TNF 3489188 62585 Recombinant human *induces* production of granulocyte-monocyte [colony stimulating factor] . Positive_regulation CSF2 TNF 3499192 79436 but not TNF-beta *induces* secretion of [colony stimulating factor] for macrophages ( CSF-1 ) by human monocytes . Positive_regulation CSF2 TNF 7505398 237620 Enzyme linked immunosorbent assay showed four of 10 glioblastoma cell lines spontaneously released GM-CSF ( 2.9-9.2 pg GM-CSF protein/ml culture medium ) , which was enhanced by stimulation with tumor necrosis factor-alpha (TNF) ( 10 U/ml ) up to 410 pg/ml . also *induced* secretion of [GM-CSF] by another cell line . Positive_regulation CSF2 TNF 7512974 253601 We further show that IL-1 alpha and synergistically *stimulate* production of [GM-CSF] and G-CSF by a clonal stroma derived cell strain . Positive_regulation CSF2 TNF 7579389 325388 We have previously shown that granulocyte-macrophage colony stimulating factor ( [GM-CSF] ) gene expression *induced* by interleukin-1 (IL-1) and in the murine stromal cell line +/+.1-LDA 11 involves activation of phospholipase A2 (PLA2) . Positive_regulation CSF2 TNF 7579439 329708 Taken together , these results raise the possibility that IL-1 alpha cross-induction of TNF receptors may contribute to the biochemical mechanisms underlying the synergistic *stimulation* of G-CSF and [GM-CSF] production by IL-1 alpha and . Positive_regulation CSF2 TNF 7691110 228737 Both IL-1 and *induced* a dose dependent release of IL-6 ( 5 to 10 ng/10 ( 6 ) cells ) and [GM-CSF] ( 2 to 3 ng/10 ( 6 ) cells ) by primary epithelial cells from eight normal volunteers . Positive_regulation CSF2 TNF 7691110 228743 The *stimulated* [GM-CSF] release was blocked by the addition of 1 microM dexamethasone , whereas basal CSF-1 release was unaffected . Positive_regulation CSF2 TNF 7782537 309684 However , most Den-Fb produced more [GM-CSF] and IL-6 in the *presence* of . Positive_regulation CSF2 TNF 7932447 275356 Transforming growth factor beta ( TGF-beta ) and to a lesser extent interferon-gamma (IFN-gamma) were able to decrease [GM-CSF] production *induced* by IL-1 and/or . Positive_regulation CSF2 TNF 7994029 283049 Production of granulocyte-macrophage [colony stimulating factor] ( GM-CSF ) , granulocyte-CSF (G-CSF) , and interleukin-1 beta (IL-1 beta) in stromal cell layers was *induced* by incubation with IL-1 alpha , , or lipopolysaccharide (LPS) . Positive_regulation CSF2 TNF 8046224 266985 A single application of 30,000 U nIL-2 *induced* selective and long lasting expression of IL-2 , IFN-gamma , and [GM-CSF] genes , which was not accompanied by accumulation of and IL-6 mRNAs . Positive_regulation CSF2 TNF 8062890 268719 The combined stimulation by IL-1 plus *resulted* in supra-additive increases in [GM-CSF] expression by +/+ ( - ) 1.LDA11 . Positive_regulation CSF2 TNF 8123762 242023 Similar to LPS , IL-2 , IL-3 , and [GM-CSF] *induced* the expression of IL-1 beta , IL-6 , IL-8 , , and IL-1-RA genes in monocytes , but with some differences in the amount and kinetics of cytokine mRNA accumulation . Positive_regulation CSF2 TNF 8282065 247368 Regulation of interleukin-1 and *induced* granulocyte-macrophage [colony stimulating factor] gene expression : potential involvement of arachidonic acid metabolism . Positive_regulation CSF2 TNF 8299733 248564 Depletion of potential accessory cells resulted in a marked stimulatory *response* of CB cells to , in the presence of [GM-CSF] , while it did not alter the responses to IFN . Positive_regulation CSF2 TNF 8347686 227014 A specific radioimmunoassay was employed to demonstrate that human articular cartilage and chondrocyte monolayers in organ and cell culture , respectively , produce macrophage [colony stimulating factor] ( M-CSF ) in *response* to stimulation with interleukin-1 alpha (IL-1 alpha) , IL-1 beta , and TNF beta . Positive_regulation CSF2 TNF 8391545 224363 TNF-alpha inhibits IFN-gamma induced HLA-DR expression and IFN-gamma blocks *dependent* synoviocyte proliferation , collagenase production , and [GM-CSF] secretion . Positive_regulation CSF2 TNF 8412318 233680 We provide experimental evidence that *induces* both GM-CSF gene expression and up-regulation of high-affinity [GM-CSF] membrane receptor in TNF alpha-responsive cells . Positive_regulation CSF2 TNF 8476629 218510 *induction* of IL-6 and [GM-CSF] was amplified synergistically in infected cultures . Positive_regulation CSF2 TNF 8503951 221223 Interleukin-1 (IL-1) and , to a lesser extent , *stimulated* [GM-CSF] formation within 3 h ; Positive_regulation CSF2 TNF 8647916 366331 *induces* transcription of the [colony stimulating factor-1] gene in murine osteoblasts . Positive_regulation CSF2 TNF 8707349 371193 The cytokines interleukin-1 beta (IL-1 beta) and IL-2 strongly *enhanced* [GM-CSF] production , while IL-4 , IL-6 , GM-CSF , interferon-gamma (IFN-gamma) and had no effect . Positive_regulation CSF2 TNF 8820249 344540 Spontaneous and *induced* [GM-CSF] or IL-8 released levels increased significantly with time . Positive_regulation CSF2 TNF 8820249 344542 *potentiated* [GM-CSF] and IL-8 release in control subjects and only the IL-8 production in asthmatics . Positive_regulation CSF2 TNF 8820249 344544 Nedocromil sodium , at the concentration of 10 ( -6 ) M , reduced the *induced* increase in [GM-CSF] but not the IL-8 release . Positive_regulation CSF2 TNF 8910536 395203 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an interleukin-1and *mediated* stimulation of macrophage [colony stimulating factor] production . Positive_regulation CSF2 TNF 8914012 395647 The production of macrophage [colony stimulating factor] ( M-CSF ) was stimulated in the *presence* of 1,25 ( OH ) 2D3 ( 50 nM ) , ( 2 ng/ml ) or both in MG-63 cells . Positive_regulation CSF2 TNF 8935186 398320 Detectable amounts of both cytokines were released in the supernatant in basal conditions at 24hr , and *increased* significantly the release of [GM-CSF] . Positive_regulation CSF2 TNF 8935186 398321 12-HETE at 10 ( -7 ) M weakly but significantly decreased the *induced* release of [GM-CSF] from HBEC . Positive_regulation CSF2 TNF 8943823 400170 The *enhancement* of [GM-CSF] production by in myofibroblasts was blocked by the inhibition of RNA synthesis . Positive_regulation CSF2 TNF 8958788 401718 Stimulation with *resulted* in an increased [GM-CSF] production in fibroblasts ( 361 +/- 14 pg/ml ) , HTh 74 ( 148 +/- 51 pg/ml ) and SW 1736 cultures ( 235 +/- 43 pg/ml ) . Positive_regulation CSF2 TNF 9187959 437074 [GM-CSF] production by EC was also *stimulated* by the combined effects of PAF and , but PAF alone did not affect GM-CSF production . Positive_regulation CSF2 TNF 9197377 438537 However , granulocyte-macrophage colony stimulating factor ( [GM-CSF] ) , a cytokine that enhances HIV replication in M/Ms and is frequently used to propagate monocytotropic strains of HIV , can *induce* the relatively long-term production of IL-6 ( up to 47 U/ml ) and ( up to 47 pg/ml ) by M/Ms , even in the absence of HIV . Positive_regulation CSF2 TNF 9647248 514967 We also demonstrate ligand independent TNF-R55 mediated cooperation in *induced* [granulocyte/macrophage-CSF] secretion , but not vice versa . Positive_regulation CSF2 TNF 9933455 589427 IL-1beta , and transforming growth factor-beta ( TGF-beta ) all stimulated GM-CSF production by RPE cells and a combination of these cytokines *increased* [GM-CSF] production over five-fold compared with that with the individual cytokines alone . Positive_regulation CSF3 EPHB2 15671148 1366085 *Roles* of Stat3 and in [G-CSF] signaling . Positive_regulation CSF3 F2R 10343541 616587 mediated signals *induce* expressions of interleukin 6 and [granulocyte colony stimulating factor] via NF-kappa B activation in synovial fibroblasts . Positive_regulation CSF3 IL1B 10029158 591526 In the present study the *roles* of and TNF-alpha in DDTC mediated [G-CSF] induction were examined using human long-term bone marrow cultures ( hLTBMCs ) . Positive_regulation CSF3 IL1B 10029158 591529 Administration of IL-1 receptor antagonist (IL-1ra) to DDTC treated hLTBMCs obviated the G-CSF induction profile and blocked the resultant colony proliferation , indicating that *mediates* DDTC induced [G-CSF] release and hematopoiesis . Positive_regulation CSF3 IL1B 11011119 752635 TNF-alpha or *induced* both [G-CSF] and PTHrP production in the conditioned medium . Positive_regulation CSF3 IL1B 12569227 1057232 Plasma interleukin (IL)-6 , IL-8 , IL-10 , [granulocyte colony stimulating factor] ( G-CSF ) , macrophage CSF (M-CSF) , and monocyte chemotactic protein 1 (MCP-1) increased significantly after the race , and urine , IL-6 , G-CSF , M-CSF , and MCP-1 *increased* significantly . Positive_regulation CSF3 IL1B 12774928 1095360 Levels of IL-6 and [G-CSF] were elevated during the active phase , but the level of did not *increase* . Positive_regulation CSF3 IL1B 2203522 140649 However , [granulocyte colony stimulating factor] expression could be *induced* by recombinant human ; Positive_regulation CSF3 IL1B 2476327 116970 The expression of granulocyte-macrophage colony stimulating factor ( GM-CSF ) and [granulocyte colony stimulating factor] ( G-CSF ) genes by stromal cells of the hematopoietic microenvironment is *regulated* , in vitro , by interleukin 1 alpha (IL-1 alpha) and . Positive_regulation CSF3 IL1B 7513199 253672 It has previously been shown that a region of the G-CSF promoter , ( -200 to -165 ) containing the decanucleotide CK-1 element and two repeated sequences that resemble nuclear factor (NF)-interleukin-6 (IL-6) binding sites , is required for *activation* of the [G-CSF] gene by tumor necrosis factor-alpha (TNF-alpha) and . Positive_regulation CSF3 IL1B 8576941 340902 Vesnarinone [ OPC-8212 ; 3,4-dihydro-6- ( 4- ( 3,4-dimethoxybenzoil ) -1-piperazinyl ) -2 ( 1H ) - quinolinone ] at 26 mumol/l significantly suppressed the production of IL-6 , granulocyte macrophage colony stimulating factor ( GM-CSF ) and [granulocyte colony stimulating factor] ( G-CSF ) *induced* by . Positive_regulation CSF3 IL1B 8639772 362561 *induces* production of [granulocyte colony stimulating factor] in human hepatoma cells . Positive_regulation CSF3 IL1B 8639772 362563 In human hepatoma HepG2 and Hep3B cells , *induced* production of the [granulocyte colony stimulating factor] ( G-CSF ) in a dose dependent manner . Positive_regulation CSF3 IL1B 8796827 381293 and tumor necrosis factor-alpha *stimulate* [granulocyte colony stimulating factor] production by placental villous core mesenchymal cells . Positive_regulation CSF3 IL1B 8796827 381295 To test the hypothesis that and tumor necrosis factor-alpha (TNF-alpha) *regulate* [granulocyte colony stimulating factor] ( G-CSF ) production by human placental villous core mesenchymal cells . Positive_regulation CSF3 IL1B 8796827 381300 and TNF-alpha *stimulate* [G-CSF] production by placental villous core mesenchymal cells in vitro . Positive_regulation CSF3 IL1B 8955505 401398 Human endometrial expression of granulocyte colony stimulating factor ( G-CSF ) and its receptor , *stimulation* of endometrial G-CSF production by , and [G-CSF] inhibition of choriocarcinoma cell proliferation . Positive_regulation CSF3 IL1B 8955505 401399 *stimulated* endometrial [G-CSF] protein production in time and dose dependent manners . Positive_regulation CSF3 IL1B 9266919 449609 [G-CSF] was *detected* only after addition of . Positive_regulation CSF3 IL1B 9755100 535336 *stimulated* the release of [G-CSF] in a dose dependent fashion , but the time dependent profile of G-CSF showed that the concentration of G-CSF declined after 48 h. Tumor necrosis factor (TNF)-alpha , Escherichia coli lipopolysaccharide (LPS) , and bradykinin ( BK ) stimulated A549 cells to release NCA that was inhibited by anti-G-CSF antibody . Positive_regulation CSF3 ITGB2 17261663 1696754 We measured circulating CD34 positive mononuclear cells , *activation* of on the surface of neutrophils , and plasma [granulocyte-colony stimulating factor] levels in 40 patients undergoing coronary stenting . Positive_regulation CSF3 PLAU 9872602 556916 [G-CSF] *increases* secretion of by human lung cancer cells . Positive_regulation CSF3 PLAU 9872602 556917 We showed that [G-CSF] *induced* a dose dependent increase in the ( uPA ) activity in the conditioned medium of a PC-9 lung cancer cell line . Positive_regulation CSF3 TNF 10029158 591525 In the present study the *roles* of IL-1beta and in DDTC mediated [G-CSF] induction were examined using human long-term bone marrow cultures ( hLTBMCs ) . Positive_regulation CSF3 TNF 10792294 689249 In addition to increasing the numbers of neutrophils in vivo and modulating neutrophil functions , [G-CSF] may *induce* the production of cytokines such as . Positive_regulation CSF3 TNF 10792294 689255 These results together with our previous findings suggest that [G-CSF] *induces* the production of and GM-CSF in vivo , and that this production may be due to the co-effects of endothelial cells and whole blood under the influence of G-CSF through an as yet unknown network of cells and cytokines . Positive_regulation CSF3 TNF 11011119 752634 or IL-1beta *induced* both [G-CSF] and PTHrP production in the conditioned medium . Positive_regulation CSF3 TNF 12034575 948789 In addition , IL-17 was found to synergistically enhance *induced* production of IL-8 , Groalpha , and [G-CSF] . Positive_regulation CSF3 TNF 12884304 1116565 Since [G-CSF] release is *mediated* , at least in part , by formation , we investigated whether drugs suppressing TNF-alpha also impair G-CSF production . Positive_regulation CSF3 TNF 1373684 186065 Dexamethasone inhibits *induced* [granulocyte colony stimulating factor] production in human endothelial cells . Positive_regulation CSF3 TNF 1373684 186066 Dexamethasone ( 10 ( -5 ) -10 ( -7 ) M ) is able to suppress the *induced* production of [granulocyte colony stimulating factor] ( G-CSF ) in human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation CSF3 TNF 15325804 1287239 While a wide range of doses of IL-17 or IL-17F alone did not up-regulate G-CSF production from primary human LMVECs , IL-17 had an enhancing effect on macrophage derived IL-1beta- and *induced* [G-CSF] production , whereas IL-17F had an enhancing effect on IL-1beta induced production , but an inhibitory effect on TNF-alpha induced secretion . Positive_regulation CSF3 TNF 15325804 1287240 Moreover , IL-17 plus Th1 or Th2 cytokine had a modest stimulatory effect on *induced* [G-CSF] production , whereas IL-17 plus IFN-gamma had an inhibitory effect on IL-1beta induced release . Positive_regulation CSF3 TNF 1700731 143375 Cytokine regulation of colony stimulating factor production in cultured human synovial fibroblasts : I. *Induction* of GM-CSF and [G-CSF] production by interleukin-1 and . Positive_regulation CSF3 TNF 1700731 143404 The transcription inhibitor , actinomycin D , and protein synthesis inhibitor , cycloheximide , inhibited the increase in GM-CSF and [G-CSF] production *induced* by IL-1 and . Positive_regulation CSF3 TNF 22790915 2719567 In addition , DMF reduced *induced* [granulocyte colony stimulating factor] ( G-CSF ) secretion but had no effect on INF-? induced G-CSF secretion . Positive_regulation CSF3 TNF 7512974 253603 We further show that IL-1 alpha and synergistically *stimulate* production of GM-CSF and [G-CSF] by a clonal stroma derived cell strain . Positive_regulation CSF3 TNF 7513199 253671 It has previously been shown that a region of the G-CSF promoter , ( -200 to -165 ) containing the decanucleotide CK-1 element and two repeated sequences that resemble nuclear factor (NF)-interleukin-6 (IL-6) binding sites , is required for *activation* of the [G-CSF] gene by and IL-1 beta . Positive_regulation CSF3 TNF 7530764 291734 We here report , by using both antisense ( AS ) oligodesoxyribonucleotide ( ODN ) and ribozyme ( RZ ) -mediated specific elimination of NF-IL6 transcripts in human fibroblasts , that *induced* synthesis of [G-CSF] , but not of GM-CSF or IL-6 , is abolished in the absence of functional NF-IL6 in vivo . Positive_regulation CSF3 TNF 7579439 329710 Taken together , these results raise the possibility that IL-1 alpha cross-induction of TNF receptors may contribute to the biochemical mechanisms underlying the synergistic *stimulation* of [G-CSF] and GM-CSF production by IL-1 alpha and . Positive_regulation CSF3 TNF 7694480 234308 In particular , we assessed whether dexamethasone was capable of inhibiting the *mediated* secretion of interleukin-6 (IL-6) , interleukin-8 (IL-8) , and [granulocyte colony stimulating factor] ( G-CSF ) by a human bronchial epithelial cell line ( BEAS-2B ) . Positive_regulation CSF3 TNF 7994029 283051 Production of granulocyte-macrophage colony stimulating factor ( GM-CSF ) , [granulocyte-CSF (G-CSF)] , and interleukin-1 beta (IL-1 beta) in stromal cell layers was *induced* by incubation with IL-1 alpha , , or lipopolysaccharide (LPS) . Positive_regulation CSF3 TNF 8796827 381292 Interleukin-1 beta and *stimulate* [granulocyte colony stimulating factor] production by placental villous core mesenchymal cells . Positive_regulation CSF3 TNF 8796827 381294 To test the hypothesis that interleukin-1 beta (IL-1 beta) and *regulate* [granulocyte colony stimulating factor] ( G-CSF ) production by human placental villous core mesenchymal cells . Positive_regulation CSF3 TNF 8796827 381298 Each cytokine *induced* [G-CSF] protein production in dose-and time dependent manners , with IL-1 beta more potent than . Positive_regulation CSF3 TNF 8796827 381299 Interleukin-1 beta and *stimulate* [G-CSF] production by placental villous core mesenchymal cells in vitro . Positive_regulation CSF3 TNF 9755100 535337 The release of [G-CSF] in *response* to , LPS , and BK was significantly increased . Positive_regulation CSK IL1B 14622206 1168655 Stimulation of IL-1 receptor by may *induce* the phosphorylation of tyrosine residues in many effector proteins through the activation of [p60c-src kinase] . Positive_regulation CSK IL1B 14622206 1168656 The hypothesis that the synthesis of SP in and secretion from the primary sensory ganglia are regulated by the activation of [p60c-src kinase] *induced* by was tested . Positive_regulation CSK IL1B 14622206 1168660 SB 203580 [ a p38 mitogen activated protein kinase ( p38 MAPK ) inhibitor ] and PD 98059 ( a p44/42 MAPK kinase inhibitor ) were ineffective in modulating *induced* SP synthesis and secretion , and [p60c-src kinase] activity in DRG neurons . Positive_regulation CSK TLR7 22235849 2591909 ligands , MALP2 , [Pam3CSK4] , LTA , and imiquimod induced high epithelial COX-2 expression , while zymosan and poly dI : dC *induced* very low enzyme expression . Positive_regulation CSK TNF 16223606 1469368 The stimulation of neutrophil-like differentiated HL60 cells with *induced* activation of NFkappaB and [c-Src kinase] , and the activation was attenuated by treatment with the anti-oxidants . Positive_regulation CSK TNF 16783405 1599405 In contrast , S. aureus ( TLR2/TLR1/TLR6 ) or Pam ( 3 ) [CSK4] ( TLR2/TLR1 ) , or FSL-1 and LTA ( TLR2/TLR6 ) *induced* without an effect on NO. 3 . Positive_regulation CSK TNF 19019456 2016908 Expression of genes associated with the MyD88- ( TNF-alpha , IL-1ss , IL-6 and IL-10 ) and TRIF dependent pathways ( IFN-ss , IP-10 , RANTES and TRAF1 ) were measured at intervals spanning 20 h . LPS and Pam ( 3 ) [CSK] ( 4 ) *induced* significantly higher expression of , IL-1ss , and IL-10 than did Poly I:C . Positive_regulation CSN2 ARSA 3588660 74096 Sodium cromoglycate ( 10 mg/kg ) selectively reduced the increases in CSN response to ASA and IND. Phentolamine ( 0.2 mg/kg ) inhibited the increased [CSN] activity *induced* by , IND , and TZ . Positive_regulation CSN2 KRT38 1372532 183061 The mammary epithelial cell lines , designated as FSK lines , were judged to be epithelial based on positive immunostaining for filaments , negative immunostaining for vimentin-intermediate filaments , hormonal *induction* of [casein] , and the ability to exhibit ductal and alveolar mammary morphogenesis in vivo . Positive_regulation CSN2 TNF 1281478 205701 Chromatography on Mono Q resolved multiple kinase peaks with each substrate tested and moreover revealed a mediated [casein] kinase-2 *activation* in both cell lines , measurable with the specific RRREEESEEE peptide or with the G peptide . Positive_regulation CSN2 TNF 1572296 187215 At low concentrations ( approximately 5 U/ml ) , *stimulated* [casein] production in parallel to its stimulation of morphological differentiation , although not to the same extent as in medium containing optimal levels of EGF . Positive_regulation CSN3 ARSA 3588660 74095 Sodium cromoglycate ( 10 mg/kg ) selectively reduced the increases in CSN response to ASA and IND. Phentolamine ( 0.2 mg/kg ) inhibited the increased [CSN] activity *induced* by , IND , and TZ . Positive_regulation CSN3 KRT38 1372532 183011 The mammary epithelial cell lines , designated as FSK lines , were judged to be epithelial based on positive immunostaining for filaments , negative immunostaining for vimentin-intermediate filaments , hormonal *induction* of [casein] , and the ability to exhibit ductal and alveolar mammary morphogenesis in vivo . Positive_regulation CSN3 TNF 1281478 205700 Chromatography on Mono Q resolved multiple kinase peaks with each substrate tested and moreover revealed a *mediated* [casein] kinase-2 activation in both cell lines , measurable with the specific RRREEESEEE peptide or with the G peptide . Positive_regulation CSN3 TNF 1572296 187214 At low concentrations ( approximately 5 U/ml ) , *stimulated* [casein] production in parallel to its stimulation of morphological differentiation , although not to the same extent as in medium containing optimal levels of EGF . Positive_regulation CSNK1E TFPI2 16790549 1585799 Here we show that protein *regulates* the kinase activity of [CKIepsilon] . Positive_regulation CSNK2A1 TF 7852847 294760 Activation of [casein kinase II] in ML-1 human myeloblastic leukemia cells *requires* IGF-1 and . Positive_regulation CSNK2A2 TF 7852847 294762 Activation of [casein kinase II] in ML-1 human myeloblastic leukemia cells *requires* IGF-1 and . Positive_regulation CSNK2B TF 7852847 294764 Activation of [casein kinase II] in ML-1 human myeloblastic leukemia cells *requires* IGF-1 and . Positive_regulation CSRP1 EMP1 17351328 1720300 This study demonstrates that [CRP] *induces* generation in HUVECs and this effect is , at least in part , related to impaired BH ( 4 ) -dependent NO production . Positive_regulation CSRP1 IL1B 11035101 741054 In the presence of overexpressed p50 , *induced* a 3-fold increase in [CRP] expression , and responses to IL-6 and to IL-6 plus IL-1beta were 4-fold greater than seen in cells without p50 overexpression . Positive_regulation CSRP1 IL1B 1424289 202241 ( ii ) IL-1 alpha and both *induced* [CRP] and SAA synthesis by HepG2 cells , but only in the presence of IL-6 . Positive_regulation CSRP1 IL1B 19950271 2172386 The interference of all 12 IFNalpha subtypes with [CRP] promoter activity *induced* by IL-6 and was studied in a CRP promoter- and luciferase reporter transfected human hepatoma cell line , Hep-G2 . Positive_regulation CSRP1 IL1B 21329621 2394142 In the third experiment , the effects of benzbromarone on *induced* [CRP] expression were determined in HuH7 cells . Positive_regulation CSRP1 IL1B 21329621 2394143 Furthermore , our in vitro findings demonstrated that benzbromarone down-regulated *stimulated* [CRP] gene expression . Positive_regulation CSRP1 IL1B 7646436 318820 In kinetic studies of the endogenous CRP gene , alone had no effect on CRP mRNA levels , but when added to IL-6 , synergistically *enhanced* both [CRP] mRNA levels and transcription , as determined by Northern-blot analyses and nuclear run-on studies . Positive_regulation CSRP1 IL1B 9256609 448382 A cytokine IL-6 induced the [CRP] production in the *presence* of , but did not affect the constitutive production of SAA . Positive_regulation CSRP1 IL1B 9359864 462279 The ability of C2 and C6 to potentiate the effects of cytokines suggests that the sphingomyelin-ceramide pathway participates in *induction* of [CRP] and SAA by under these experimental conditions , most likely by transducing the effects of IL-1beta . Positive_regulation CSRP1 TNF 1424289 202247 ( iv ) in the presence or absence of IL-6 and/or prednisolone did not *induce* the production of SAA or [CRP] by HepG2 cells . Positive_regulation CSRP1 TNF 15653107 1364392 [CRP] *induced* the enhanced release of IL-6 and by 17-fold and 23-fold increase , respectively , in patients with unstable angina , while it did about 11-fold and 19-fold increase in patients with stable angina and normal group ( IL-6 : 3129+/-333 vs. 991+/-134 and 987+/-102 pg/ml , p < 0.01 , respectively ; Positive_regulation CSRP1 TNF 1651357 163081 alone *had* no significant effect on synthesis of either SAA or [CRP] , but the combination of IL-6 plus TNF-alpha led to substantial induction of SAA . Positive_regulation CSRP1 TNF 17704137 1794572 We investigated the mechanism of *induced* [CRP] expression and found that the p50 subunit of NF-kappaB was responsible for the transcriptional activation of CRP . Positive_regulation CSRP1 TNF 19483409 2085966 The results , indicated that the IL-6 signal was essential though the activation of STAT3 for the *induction* and augmentation of [CRP] or SAA by the associated stimulation with or IL-1 . Positive_regulation CST6 ADRB1 1685882 175325 The findings suggest that the induction of salivary [cystatin] is *regulated* , in part , by stimulation . Positive_regulation CST6 CTSL 16874311 1672479 Recently , we provided biochemical evidence that human cathepsin V (CTSV) and are additional biological *targets* for human [cystatin M/E] . Positive_regulation CST6 CTSS 15161240 1252813 The and MTGase activities in WSP , SSP , and MP solutions decreased , but the recombinant [cystatin] activity *increased* during setting at 45 degrees C . Positive_regulation CST6 CTSV 16874311 1672480 Recently , we provided biochemical evidence that human and cathepsin L (CTSL) are additional biological *targets* for human [cystatin M/E] . Positive_regulation CST6 SDS 11479377 843570 It is , therefore , evident that an *dependent* conformational change of the protease itself , rather than the release of [cystatin] from the complex , is crucial for the activation . Positive_regulation CSTA EPHB2 11451947 860113 These results indicate that the expression of [cystatin A] is *regulated* via mitogen activated protein kinase pathways positively by Ras/MEKK1/MKK7/JNK and negatively by . Positive_regulation CSTF1 CFI 11713271 880808 In Saccharomyces cerevisiae , in vitro mRNA cleavage and [polyadenylation] *require* the poly ( A ) binding protein , Pab1p , and two multiprotein complexes : ( cleavage factor I ) and CPF ( cleavage and polyadenylation factor ) . Positive_regulation CSTF1 LGALS7B 9174099 433506 Northern blot analysis , PCR amplification , and DNA sequence analysis show that the signal *directs* [polyadenylation] within the body of pre-SUP4 and within the terminator , suggesting that polyadenylation inhibits 5 ' and 3 ' end processing , as well as removal of the pre-tRNA intron . Positive_regulation CSTF2 CFI 11713271 880814 In Saccharomyces cerevisiae , in vitro mRNA cleavage and [polyadenylation] *require* the poly ( A ) binding protein , Pab1p , and two multiprotein complexes : ( cleavage factor I ) and CPF ( cleavage and polyadenylation factor ) . Positive_regulation CSTF2 LGALS7B 9174099 433507 Northern blot analysis , PCR amplification , and DNA sequence analysis show that the signal *directs* [polyadenylation] within the body of pre-SUP4 and within the terminator , suggesting that polyadenylation inhibits 5 ' and 3 ' end processing , as well as removal of the pre-tRNA intron . Positive_regulation CSTF3 CFI 11713271 880820 In Saccharomyces cerevisiae , in vitro mRNA cleavage and [polyadenylation] *require* the poly ( A ) binding protein , Pab1p , and two multiprotein complexes : ( cleavage factor I ) and CPF ( cleavage and polyadenylation factor ) . Positive_regulation CSTF3 LGALS7B 9174099 433508 Northern blot analysis , PCR amplification , and DNA sequence analysis show that the signal *directs* [polyadenylation] within the body of pre-SUP4 and within the terminator , suggesting that polyadenylation inhibits 5 ' and 3 ' end processing , as well as removal of the pre-tRNA intron . Positive_regulation CTBS IGFBP1 9778118 540331 Since in contrast to DESCM , *increases* the total gelatinolytic activity of [CTB] , it can not be the primary active decidual factor regulating the proteolytic activity of CTB . Positive_regulation CTD CDKN1C 20106982 2226561 We find that adenoviral mediated overexpression of *leads* to a dramatic reduction in phosphorylation of the RNA polymerase II (pol II) [C-terminal domain (CTD)] . Positive_regulation CTD CFI 22290438 2565107 recruitment to this defined region may *result* from simultaneous binding to the Spt5 CTR , to nascent RNA containing the pA sequence , and to the elongating Pol II isoform that is phosphorylated at serine 2 ( S2 ) residues in its [C-terminal domain (CTD)] . Positive_regulation CTD TNF 15879558 1406183 To investigate the determinants of promoter-specific gene regulation by the glucocorticoid receptor (GR) , we compared the composition and function of regulatory complexes at two NFkappaB-responsive genes that are differentially regulated by GR. Transcription of the IL-8 and IkappaBalpha genes is *stimulated* by in A549 cells , but GR selectively represses IL-8 mRNA synthesis by inhibiting Ser2 phosphorylation of the RNA polymerase II (pol II) [C-terminal domain (CTD)] . Positive_regulation CTDP1 EDN2 12368904 998444 A preferential role for Cdk9 was shown in [RNA polymerase II] phosphorylation and growth *induced* by , using pharmacological and dominant negative inhibitors . Positive_regulation CTDP1 IL1B 12649265 1080001 induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and *stimulated* [RNA polymerase II] binding to the COX-2 promoter , COX-2 transcription , COX-2 protein synthesis , and prostaglandin E2 ( PGE2 ) release . Positive_regulation CTDP1 TNF 18688044 1961006 *induced* inflammatory gene expression , H3K4me2 levels , and recruitment of [RNA polymerase II] at the gene promoters were also enhanced in db/db VSMCs , demonstrating the formation of open chromatin poised for transcriptional activation in diabetes . Positive_regulation CTDP1 TNF 19734226 2139665 Furthermore , chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and [RNA polymerase II] to the CXCL8 promoter of asthmatic HASM cells both in the *presence* and absence of stimulation . Positive_regulation CTF1 CAPN8 22580607 2757103 Spheroidgenesis and lymphovascular emboli formation are the direct result of *mediated* cleavage of E-cad and the generation of E-cad/NTF1 from membrane associated E-cad rather than the de novo presence of either E-cad/NTF1 or [E-cad/CTF1] . Positive_regulation CTF1 EDN2 11834704 911107 [Cardiotrophin-1] stimulation of cardiac fibroblast growth : *roles* for glycoprotein 130/leukemia inhibitory factor receptor and the type A receptor . Positive_regulation CTF1 TNF 20224758 2181108 [Cardiotrophin-1] *induces* alpha synthesis in human peripheral blood mononuclear cells . Positive_regulation CTF1 TNF 8939900 398546 Furthermore , TNF-alpha is unable to repress CTF-1 activity in NIH3T3 cells overexpressing ras or raf , suggesting that *regulates* [CTF-1] by a Ras-Raf kinase dependent pathway . Positive_regulation CTGF AKT1 12218048 1012101 The *role* of p42/44 MAPK and in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Positive_regulation CTGF AKT1 19208742 2039230 Activation of FoxO transcription factors by inhibition of phosphatidylinositol <3-kinase/AKT> signaling *resulted* in a synergistic increase in CA-4P mediated [CTGF] induction . Positive_regulation CTGF AKT1 20201953 2259333 blockade using a specific pharmacological inhibitor and Akt siRNA *resulted* in a significant up-regulation of [CCN2] , which correlated with the increase in MMP1 . Positive_regulation CTGF AKT1 20213804 2249213 [CTGF] *induced* phosphorylation of p38 , ERK-1/2 , JNK , and , but not Smad3 , in transgenic mouse fibroblasts compared with wild-type mouse fibroblasts . Positive_regulation CTGF AKT1 20382513 2287746 Furthermore , the augmented expression of [CTGF] and TIMP-2 in HG-exposed cells was *mediated* by activation and TGF-beta/Smad signaling through PKCbeta2-responsive signaling pathways . Positive_regulation CTGF AKT1 21184784 2452944 Endocytosis inhibition increased canonical Smad signaling and culminated in a superinduction of Id1 and Smad7 expression , whereas caveolin-1 mediated pathway activation was *required* for maximal [CTGF] induction . Positive_regulation CTGF AKT2 19208742 2039231 Activation of FoxO transcription factors by inhibition of phosphatidylinositol <3-kinase/AKT> signaling *resulted* in a synergistic increase in CA-4P mediated [CTGF] induction . Positive_regulation CTGF AKT2 20201953 2259334 blockade using a specific pharmacological inhibitor and Akt siRNA *resulted* in a significant up-regulation of [CCN2] , which correlated with the increase in MMP1 . Positive_regulation CTGF AKT2 20213804 2249214 [CTGF] *induced* phosphorylation of p38 , ERK-1/2 , JNK , and , but not Smad3 , in transgenic mouse fibroblasts compared with wild-type mouse fibroblasts . Positive_regulation CTGF AKT2 20382513 2287747 Furthermore , the augmented expression of [CTGF] and TIMP-2 in HG-exposed cells was *mediated* by activation and TGF-beta/Smad signaling through PKCbeta2-responsive signaling pathways . Positive_regulation CTGF AKT2 21184784 2452945 Endocytosis inhibition increased canonical Smad signaling and culminated in a superinduction of Id1 and Smad7 expression , whereas caveolin-1 mediated pathway activation was *required* for maximal [CTGF] induction . Positive_regulation CTGF AKT3 19208742 2039232 Activation of FoxO transcription factors by inhibition of phosphatidylinositol <3-kinase/AKT> signaling *resulted* in a synergistic increase in CA-4P mediated [CTGF] induction . Positive_regulation CTGF AKT3 20201953 2259335 blockade using a specific pharmacological inhibitor and Akt siRNA *resulted* in a significant up-regulation of [CCN2] , which correlated with the increase in MMP1 . Positive_regulation CTGF AKT3 20213804 2249215 [CTGF] *induced* phosphorylation of p38 , ERK-1/2 , JNK , and , but not Smad3 , in transgenic mouse fibroblasts compared with wild-type mouse fibroblasts . Positive_regulation CTGF AKT3 20382513 2287748 Furthermore , the augmented expression of [CTGF] and TIMP-2 in HG-exposed cells was *mediated* by activation and TGF-beta/Smad signaling through PKCbeta2-responsive signaling pathways . Positive_regulation CTGF AKT3 21184784 2452946 Endocytosis inhibition increased canonical Smad signaling and culminated in a superinduction of Id1 and Smad7 expression , whereas caveolin-1 mediated pathway activation was *required* for maximal [CTGF] induction . Positive_regulation CTGF ANG 20035857 2217850 II may *induce* [CTGF] expression in the heart and kidney and plays an important role in the pathogenesis of lung fibrosis . Positive_regulation CTGF ANG 22461303 2624497 in the CNT lumen *enhances* [CTGF] via PKC . Positive_regulation CTGF ANGPT2 12819040 1103868 In transgenic rats harboring human renin and angiotensinogen genes , *induced* an age dependent increase in myocardial [CTGF] expression , which was 3.5-fold greater compared to normotensive Sprague Dawley ( SD ) rats . Positive_regulation CTGF ANGPT2 12952842 1143274 In growth arrested vascular smooth muscle cells , induced CTGF mRNA expression after 1 hour , remained elevated up to 24 hours , and *increased* [CTGF] protein production , which was increased up to 72 hours . Positive_regulation CTGF ANGPT2 12952842 1143276 Our results show that , via AT1 , *increases* [CTGF] in vascular cells both in vivo and in vitro . Positive_regulation CTGF ANGPT2 17074304 1675195 In growth arrested VSMCs , rosiglitazone attenuated the proliferation and apoptosis , increased PPAR-gamma production and activation , and reduced [CTGF] and ECM production in *response* to in a dose dependent fashion . Positive_regulation CTGF ANGPT2 17592071 1768142 In these cells *regulated* [CTGF] via RhoA/Rho kinase activation , as shown by inhibition of Rho with C3 exoenzyme , RhoA dominant negative overexpression , and Rho kinase inhibition . Positive_regulation CTGF ANGPT2 17651610 1776076 promoted HLF cell transdifferentiation into myofibroblasts and *increased* collagen production through induction of [CTGF] expression . Positive_regulation CTGF ANGPT2 18716373 1951037 The results demonstrated that , in cultured AFs , *increased* [CTGF] production via AT(1)-R , which could be mediators of collagen synthesis by Ang II . Positive_regulation CTGF ANGPT2 19667256 2138711 Additional studies revealed that , in addition to a late ( 24-hour ) TGF-beta dependent Smad2/3 activation , also *induced* a rapid activation of Smad2/3 at 15 minutes and expression of [CTGF] and collagen I in tubular epithelial cells lacking the TGF-beta gene , which was blocked by the addition of an Ang II type 1 receptor antagonist ( losartan ) and inhibitors to extracellular signal regulated kinase 1/2 ( PD98059 ) and p38 ( SB203580 ) but not by inhibitors to Ang II type 2 receptor ( PD123319 ) or c-Jun N-terminal kinase ( SP600125 ) , demonstrating a TGF-beta independent , Ang II type 1 receptor mediated extracellular signal regulated kinase/p38 mitogen activated protein kinase cross-talk pathway in Ang II-mediated CTGF and collagen I expression . Positive_regulation CTGF ANGPT2 19667256 2138722 In conclusion , *induces* tubular [CTGF] expression and renal fibrosis via the TGF-beta dependent and -independent Smad3 signaling pathways , suggesting that targeting Smad3 may have therapeutic potential for hypertensive nephropathy . Positive_regulation CTGF ANGPT2 20696981 2317584 We hypothesized that in the CNT lumen *enhances* [CTGF] by activation of Ang II type 1 receptors , protein kinase C and ENaC . Positive_regulation CTGF ANGPT2 20696981 2317585 We concluded that in the CNT lumen *enhances* [CTGF] via activation of Ang II type 1 and that this effect requires activation of protein kinase C and ENaC . Positive_regulation CTGF ANGPT2 21576830 2445638 In perfused rat hearts , stimulation *increased* [CTGF] expression , which could be inhibited by Ang II type I receptor antagonist . Positive_regulation CTGF ANGPT2 21719784 2451686 can directly *induce* expression of renal [CTGF] and mediate epithelial-mesenchymal transition . Positive_regulation CTGF ANGPT2 22461303 2624500 We conclude the PKC/NOX2/O ( 2 ) ( - ) pathway mediates the *enhancement* of [CTGF] by luminal but it does not participate in CTGF in the absence of ANG II . Positive_regulation CTGF ANGPT2 22964022 2678753 In this paper , we show that in myoblasts , *induced* the increase of transforming growth factor beta 1 ( TGF-ß1 ) and [connective tissue growth factor (CTGF)] expression through its AT-1 receptor . Positive_regulation CTGF ANGPT2 22964022 2678787 However , only the p38MAPK activity was critical for the Ang-II induced fibrotic effects , as indicated by the decrease in the *induced* TGF-ß1 and [CTGF] expression and fibronectin levels by SB-203580 , an inhibitor of the p38MAPK , but not by U0126 , an inhibitor of ERK1/2 phosphorylation . Positive_regulation CTGF ANGPT2 23254997 2822832 Here , we show that inhibition of NF-?B in cardiac fibroblast restores miR-26a expression , attenuating collagen I , and [CTGF] gene expression in the *presence* of , conferring a feedback regulatory mechanism in cardiac fibrosis . Positive_regulation CTGF ANGPT2 24296617 2904766 Secondly , *increased* the level of [CTGF] significantly ( p < 0.05 vs. control ) , which was also prevented by pretreatment with telmisartan . Positive_regulation CTGF ANGPT2 24296617 2904768 Finally , transfection of miR-19b into cardiomyocytes prevented the upregulation of [CTGF] *induced* by . Positive_regulation CTGF APOB 15780081 1385167 Evidence for low-density *induced* expression of [connective tissue growth factor] in mesangial cells . Positive_regulation CTGF APOB 15780081 1385185 The increase in [CTGF] and collagen I *induced* by was significantly inhibited by neutralizing anti-TGF-beta antibodies . Positive_regulation CTGF APOB 15780081 1385193 Inhibition of p38 ( mapk ) or p42/44(mapk) activities did not affect LDL induced TGF-beta1 , CTGF , and collagen I expression , whereas inhibition of c-Jun NH2-terminal kinase (JNK) suppressed *induced* TGF-beta , [CTGF] , and collagen I expression . Positive_regulation CTGF APOB 16272194 1532153 Mechanisms of low-density *induced* expression of [connective tissue growth factor] in human aortic endothelial cells . Positive_regulation CTGF APOB 16272194 1532167 To explore the mechanisms by which *regulates* [CTGF] and collagen IV expression in HAECs , we determined first if CTGF and collagen IV are downstream targets for regulation by transforming growth factor-beta ( TGF-beta ) . Positive_regulation CTGF APOB 16272194 1532196 To assess whether the induction of [CTGF] in *response* to is mediated via autocrine activation of TGF-beta , HAECs were treated with LDL for 24 h in the presence and absence of anti-TGF-beta neutralizing antibodies ( anti-TGF-beta NA ) . Positive_regulation CTGF APOB 16272194 1532198 The results demonstrated that the increase in [CTGF] *induced* by was significantly inhibited by the anti-TGF-beta NA . Positive_regulation CTGF APOB 16272194 1532199 To investigate the upstream mediators of TGF-beta on activity of [CTGF] in *response* to , HAECs were treated with LDL for 24 h in the presence and absence of cell-permeable MAPK inhibitors . Positive_regulation CTGF APOB 16272194 1532208 Inhibition of p38 ( mapk ) activities did not affect *induced* TGF-beta1 , [CTGF] , and collagen IV expression . Positive_regulation CTGF APOB 16272194 1532223 On the other hand , SP-600125 , a specific inhibitor of c-Jun NH ( 2 ) -terminal kinase , suppressed LDL induced TGF-beta , CTGF , and collagen IV expression , and PD-98059 , a selective inhibitor of p44/42(mapk) , suppressed *induced* TGF-beta and [CTGF] expression . Positive_regulation CTGF APOB 22422617 2588062 Low-density *induced* expression of [connective tissue growth factor] via transactivation of sphingosine 1-phosphate receptors in mesangial cells . Positive_regulation CTGF APOB 22422617 2588066 We recently reported that *induced* expression of [CTGF] in aortic endothelial cells . Positive_regulation CTGF APOB 22422617 2588068 Here , we have studied the mechanism by which *regulates* [CTGF] expression in renal mesangial cells . Positive_regulation CTGF APOB 22422617 2588079 *induced* [CTGF] expression was pertussis toxin sensitive and inhibited by dimethylsphinogsine down-regulation of SK1 and VPC23019 treatment . Positive_regulation CTGF BAMBI 21496456 2422946 Overexpression of in hepatoma cells *impairs* TGFß mediated phosphorylation of SMAD2 and induction of [connective tissue growth factor] . Positive_regulation CTGF BLM 16337105 1503846 Moreover , 15-d PGJ2 down-regulation of the expression of transforming growth factor beta(1) and [connective tissue growth factor] which had been *induced* by . Positive_regulation CTGF BMP1 24112732 2852625 Importantly , Noggin treatment inhibited endogenous and BMP induced CCN2 expression , verifying that [CCN2] expression in developing tooth germs *requires* signalling . Positive_regulation CTGF BMP10 24112732 2852633 Importantly , Noggin treatment inhibited endogenous and BMP induced CCN2 expression , verifying that [CCN2] expression in developing tooth germs *requires* signalling . Positive_regulation CTGF BMP15 24112732 2852626 Importantly , Noggin treatment inhibited endogenous and BMP induced CCN2 expression , verifying that [CCN2] expression in developing tooth germs *requires* signalling . Positive_regulation CTGF BMP2 10950824 723474 Parathyroid hormone decreased , whereas transforming growth factor-beta and , to a lesser extent , *increased* [CTGF/IGFBP-rP2] mRNA levels , but other hormones and growth factors had no effect . Positive_regulation CTGF BMP2 24112732 2852627 Importantly , Noggin treatment inhibited endogenous and BMP induced CCN2 expression , verifying that [CCN2] expression in developing tooth germs *requires* signalling . Positive_regulation CTGF BMP3 24112732 2852628 Importantly , Noggin treatment inhibited endogenous and BMP induced CCN2 expression , verifying that [CCN2] expression in developing tooth germs *requires* signalling . Positive_regulation CTGF BMP4 24112732 2852629 Importantly , Noggin treatment inhibited endogenous and BMP induced CCN2 expression , verifying that [CCN2] expression in developing tooth germs *requires* signalling . Positive_regulation CTGF BMP5 24112732 2852630 Importantly , Noggin treatment inhibited endogenous and BMP induced CCN2 expression , verifying that [CCN2] expression in developing tooth germs *requires* signalling . Positive_regulation CTGF BMP6 24112732 2852631 Importantly , Noggin treatment inhibited endogenous and BMP induced CCN2 expression , verifying that [CCN2] expression in developing tooth germs *requires* signalling . Positive_regulation CTGF BMP7 19957515 2172834 To investigate the effects of upon epithelial-to-mesenchymal transition ( EMT ) and the expression of [connective tissue growth factor (CTGF)] in human renal proximal tubular epithelial cells ( HK-2 ) *induced* by transforming growth factor-beta1 , ( TGF-beta1 ) and to explore the possible mechanisms of BMP-7 for the inhibition and reversal of renal interstitial fibrosis . Positive_regulation CTGF BMP7 24112732 2852632 Importantly , Noggin treatment inhibited endogenous and BMP induced CCN2 expression , verifying that [CCN2] expression in developing tooth germs *requires* signalling . Positive_regulation CTGF CA4 19208742 2039192 Concomitantly , *up-regulated* [connective tissue growth factor] ( CTGF/CCN2 ) , a pleiotropic factor with antiangiogenic properties . Positive_regulation CTGF CA4 19208742 2039194 Furthermore , *induced* [CTGF] expression in endothelial cells , forming tube-like structures on basement membrane gels . Positive_regulation CTGF CA4 19208742 2039196 *Up-regulation* of [CTGF] by was dependent on Rho kinase signaling and was increased when p42/44 mitogen activated protein kinase was inhibited . Positive_regulation CTGF CA4 19208742 2039226 Activation of FoxO transcription factors by inhibition of phosphatidylinositol 3-kinase/AKT signaling resulted in a synergistic increase in mediated [CTGF] *induction* . Positive_regulation CTGF CA4 19208742 2039236 *mediated* expression of [CTGF] was thus potentiated by the inhibition of kinase pathways , which are targets of novel antineoplastic drugs . Positive_regulation CTGF CALCA 19307750 2086983 *induces* [connective tissue growth factor] through ERK1/2 signaling in renal tubular cells . Positive_regulation CTGF CAPN1 18266973 2005951 Cycloheximide did not abolish the rapid immunocytochemical appearance of mature TGF-beta , but inhibitors partially *suppressed* intracellular TGF-beta activation and subsequently [CTGF] up-regulation . Positive_regulation CTGF CAPN10 18266973 2005952 Cycloheximide did not abolish the rapid immunocytochemical appearance of mature TGF-beta , but inhibitors partially *suppressed* intracellular TGF-beta activation and subsequently [CTGF] up-regulation . Positive_regulation CTGF CAPN11 18266973 2005953 Cycloheximide did not abolish the rapid immunocytochemical appearance of mature TGF-beta , but inhibitors partially *suppressed* intracellular TGF-beta activation and subsequently [CTGF] up-regulation . Positive_regulation CTGF CAPN12 18266973 2005950 Cycloheximide did not abolish the rapid immunocytochemical appearance of mature TGF-beta , but inhibitors partially *suppressed* intracellular TGF-beta activation and subsequently [CTGF] up-regulation . Positive_regulation CTGF CAPN13 18266973 2005961 Cycloheximide did not abolish the rapid immunocytochemical appearance of mature TGF-beta , but inhibitors partially *suppressed* intracellular TGF-beta activation and subsequently [CTGF] up-regulation . Positive_regulation CTGF CAPN14 18266973 2005962 Cycloheximide did not abolish the rapid immunocytochemical appearance of mature TGF-beta , but inhibitors partially *suppressed* intracellular TGF-beta activation and subsequently [CTGF] up-regulation . Positive_regulation CTGF CAPN15 18266973 2005949 Cycloheximide did not abolish the rapid immunocytochemical appearance of mature TGF-beta , but inhibitors partially *suppressed* intracellular TGF-beta activation and subsequently [CTGF] up-regulation . Positive_regulation CTGF CAPN2 18266973 2005954 Cycloheximide did not abolish the rapid immunocytochemical appearance of mature TGF-beta , but inhibitors partially *suppressed* intracellular TGF-beta activation and subsequently [CTGF] up-regulation . Positive_regulation CTGF CAPN3 18266973 2005955 Cycloheximide did not abolish the rapid immunocytochemical appearance of mature TGF-beta , but inhibitors partially *suppressed* intracellular TGF-beta activation and subsequently [CTGF] up-regulation . Positive_regulation CTGF CAPN5 18266973 2005956 Cycloheximide did not abolish the rapid immunocytochemical appearance of mature TGF-beta , but inhibitors partially *suppressed* intracellular TGF-beta activation and subsequently [CTGF] up-regulation . Positive_regulation CTGF CAPN6 18266973 2005957 Cycloheximide did not abolish the rapid immunocytochemical appearance of mature TGF-beta , but inhibitors partially *suppressed* intracellular TGF-beta activation and subsequently [CTGF] up-regulation . Positive_regulation CTGF CAPN7 18266973 2005958 Cycloheximide did not abolish the rapid immunocytochemical appearance of mature TGF-beta , but inhibitors partially *suppressed* intracellular TGF-beta activation and subsequently [CTGF] up-regulation . Positive_regulation CTGF CAPN8 18266973 2005959 Cycloheximide did not abolish the rapid immunocytochemical appearance of mature TGF-beta , but inhibitors partially *suppressed* intracellular TGF-beta activation and subsequently [CTGF] up-regulation . Positive_regulation CTGF CAPN9 18266973 2005960 Cycloheximide did not abolish the rapid immunocytochemical appearance of mature TGF-beta , but inhibitors partially *suppressed* intracellular TGF-beta activation and subsequently [CTGF] up-regulation . Positive_regulation CTGF CASP3 19730442 2186481 *mediated* secretion of [connective tissue growth factor] by apoptotic endothelial cells promotes fibrosis . Positive_regulation CTGF CAV1 21184784 2452943 Endocytosis inhibition increased canonical Smad signaling and culminated in a superinduction of Id1 and Smad7 expression , whereas mediated AKT pathway activation was *required* for maximal [CTGF] induction . Positive_regulation CTGF CAV1 22277251 2642805 This study was undertaken to evaluate the *role* of in Smad1 signaling and [CCN2] expression in healthy and SSc dermal fibroblasts . Positive_regulation CTGF CBX1 20410198 2262412 In the kidney , [connective tissue growth factor] mRNA levels were *increased* by DOC and ; Positive_regulation CTGF CBX2 20410198 2262413 In the kidney , [connective tissue growth factor] mRNA levels were *increased* by DOC and ; Positive_regulation CTGF CBX3 20410198 2262414 In the kidney , [connective tissue growth factor] mRNA levels were *increased* by DOC and ; Positive_regulation CTGF CBX4 20410198 2262415 In the kidney , [connective tissue growth factor] mRNA levels were *increased* by DOC and ; Positive_regulation CTGF CBX5 20410198 2262416 In the kidney , [connective tissue growth factor] mRNA levels were *increased* by DOC and ; Positive_regulation CTGF CBX6 20410198 2262417 In the kidney , [connective tissue growth factor] mRNA levels were *increased* by DOC and ; Positive_regulation CTGF CBX7 20410198 2262418 In the kidney , [connective tissue growth factor] mRNA levels were *increased* by DOC and ; Positive_regulation CTGF CBX8 20410198 2262419 In the kidney , [connective tissue growth factor] mRNA levels were *increased* by DOC and ; Positive_regulation CTGF CCL2 16320328 1490882 In these cultures , specific inhibition of or CCR2 *attenuated* the overexpression of alpha-SMA , but not [CTGF] or plasminogen activator inhibitor 1 . Positive_regulation CTGF CCL2 16408113 1513547 In conclusion , these results demonstrate that [CTGF] *induces* production of fractalkine , , and RANTES via the p42/44 MAPK- , PI3-K/Akt- , and NF-kappaB dependent signal pathway , and LXA ( 4 ) downregulates the above effects of CTGF on rat mesangial cells . Positive_regulation CTGF CCL2 19378419 2007969 These results demonstrated that [CTGF] *induces* production of fractalkine , and RANTES via ERK1/2 and PI3-K/PKB/NF-kappaB dependent signal pathway mediated by cell surface heparin sulfate proteoglycans and the tyrosine kinase receptor TrkA in human mesangial cells . Positive_regulation CTGF CCR2 16320328 1490883 In these cultures , specific inhibition of CCL2 or *attenuated* the overexpression of alpha-SMA , but not [CTGF] or plasminogen activator inhibitor 1 . Positive_regulation CTGF CD6 16343439 1504082 Adenovirus mediated introduction of c-maf gene into the mouse fibroblast cell line strongly *induced* [CTGF] expression . Positive_regulation CTGF CKAP4 22438586 2594520 In addition , we demonstrate that CKAP4 translocates to the nucleus and binds to the CCN2 proximal promoter in an APF dependent manner , providing evidence that [CCN2] regulation by APF *involves* nuclear translocation and binding to the CCN2 promoter . Positive_regulation CTGF COL1A1 23906792 2866071 [Connective tissue growth factor] *induces* expression in human lung fibroblasts through the Rac1/MLK3/JNK/AP-1 pathway . Positive_regulation CTGF COL1A1 23906792 2866083 These results suggest for the first time that [CTGF] acting through Rac1 activates the MLK3/JNK signaling pathway , which in turn initiates AP-1 activation and recruitment of c-Jun and c-Fos to the collagen I promoter and ultimately *induces* expression in human lung fibroblasts . Positive_regulation CTGF COL1A2 23906792 2866072 [Connective tissue growth factor] *induces* expression in human lung fibroblasts through the Rac1/MLK3/JNK/AP-1 pathway . Positive_regulation CTGF COL1A2 23906792 2866084 These results suggest for the first time that [CTGF] acting through Rac1 activates the MLK3/JNK signaling pathway , which in turn initiates AP-1 activation and recruitment of c-Jun and c-Fos to the collagen I promoter and ultimately *induces* expression in human lung fibroblasts . Positive_regulation CTGF COL4A1 15536170 1374823 [CTGF] ( 20 ng/ml ) *induced* fibronectin and secretion in primary cultures of human proximal tubule cells (PTC) and cortical fibroblasts ( CF ) compared with control values ( P < 0.005 in all cases ) . Positive_regulation CTGF COL4A1 16528248 1536303 [CTGF] significantly *induced* cell hypertrophy , increased fibronectin , and secretion in PTCs and CFs . Positive_regulation CTGF COL4A2 15536170 1374824 [CTGF] ( 20 ng/ml ) *induced* fibronectin and secretion in primary cultures of human proximal tubule cells (PTC) and cortical fibroblasts ( CF ) compared with control values ( P < 0.005 in all cases ) . Positive_regulation CTGF COL4A2 16528248 1536304 [CTGF] significantly *induced* cell hypertrophy , increased fibronectin , and secretion in PTCs and CFs . Positive_regulation CTGF COL4A3 15536170 1374825 [CTGF] ( 20 ng/ml ) *induced* fibronectin and secretion in primary cultures of human proximal tubule cells (PTC) and cortical fibroblasts ( CF ) compared with control values ( P < 0.005 in all cases ) . Positive_regulation CTGF COL4A3 16528248 1536305 [CTGF] significantly *induced* cell hypertrophy , increased fibronectin , and secretion in PTCs and CFs . Positive_regulation CTGF COL4A4 15536170 1374826 [CTGF] ( 20 ng/ml ) *induced* fibronectin and secretion in primary cultures of human proximal tubule cells (PTC) and cortical fibroblasts ( CF ) compared with control values ( P < 0.005 in all cases ) . Positive_regulation CTGF COL4A4 16528248 1536306 [CTGF] significantly *induced* cell hypertrophy , increased fibronectin , and secretion in PTCs and CFs . Positive_regulation CTGF COL4A5 15536170 1374827 [CTGF] ( 20 ng/ml ) *induced* fibronectin and secretion in primary cultures of human proximal tubule cells (PTC) and cortical fibroblasts ( CF ) compared with control values ( P < 0.005 in all cases ) . Positive_regulation CTGF COL4A5 16528248 1536307 [CTGF] significantly *induced* cell hypertrophy , increased fibronectin , and secretion in PTCs and CFs . Positive_regulation CTGF COL4A6 15536170 1374828 [CTGF] ( 20 ng/ml ) *induced* fibronectin and secretion in primary cultures of human proximal tubule cells (PTC) and cortical fibroblasts ( CF ) compared with control values ( P < 0.005 in all cases ) . Positive_regulation CTGF COL4A6 16528248 1536308 [CTGF] significantly *induced* cell hypertrophy , increased fibronectin , and secretion in PTCs and CFs . Positive_regulation CTGF CORT 20410198 2262420 In the kidney , [connective tissue growth factor] mRNA levels were *increased* by DOC and ; Positive_regulation CTGF CRK 17592071 1768144 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Positive_regulation CTGF CSF1 19594046 2105402 The expression of CTGF and M-CSF protein is up regulated in osteoarthritis chondrocytes , which suggests that the activation of is *involved* in the production of [CTGF] . Positive_regulation CTGF CTNNB1 20571031 2308990 On the other hand , the same assays showed that in hypertrophic chondrocytes , TCF x LEF x complexes occupy the consensus TCF x LEF x Sox9 site and *activate* [Ccn2] expression . Positive_regulation CTGF CX3CL1 16408113 1513548 In conclusion , these results demonstrate that [CTGF] *induces* production of , MCP-1 , and RANTES via the p42/44 MAPK- , PI3-K/Akt- , and NF-kappaB dependent signal pathway , and LXA ( 4 ) downregulates the above effects of CTGF on rat mesangial cells . Positive_regulation CTGF DCN 21454550 2448150 Finally , we showed that [CTGF] specifically *induced* the synthesis of , suggesting a mechanism of autoregulation . Positive_regulation CTGF DLL1 21473864 2428152 Data suggest that *upregulates* [CTGF] promoter activity through both direct and indirect mechanisms . Positive_regulation CTGF DLL1 21473864 2428160 The indirect *upregulation* of [CTGF] expression by is likely due to the ability of Dll1icd to increase Wnt signaling , a pathway that targets CTGF . Positive_regulation CTGF DOT1L 20053791 2211779 Overexpression of or treatment with forskolin dramatically *suppressed* basal [CTGF] mRNA levels and CTGF promoter-luciferase activity , while hypermethylating H3K79 in chromatin associated with the CTGF promoter . Positive_regulation CTGF ECM1 12218048 1012099 The role of p42/44 MAPK and protein kinase B in [connective tissue growth factor] *induced* production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Positive_regulation CTGF ECM1 22280508 2545403 TGF-ß/Smad-3 independent up-regulation of [CTGF] may *induce* accumulation of proteins and maintain fibrosis in chronic LS . Positive_regulation CTGF ECM1 24392320 2883988 TGF-ß2 and [CTGF] could *induce* HLECs epithelial mesenchymal transition and synthesis . Positive_regulation CTGF ECM2 12218048 1012100 The role of p42/44 MAPK and protein kinase B in [connective tissue growth factor] *induced* production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Positive_regulation CTGF ECM2 22280508 2545404 TGF-ß/Smad-3 independent up-regulation of [CTGF] may *induce* accumulation of proteins and maintain fibrosis in chronic LS . Positive_regulation CTGF ECM2 24392320 2883989 TGF-ß2 and [CTGF] could *induce* HLECs epithelial mesenchymal transition and synthesis . Positive_regulation CTGF EDAR 16769906 1572602 activation also *induces* [connective tissue growth factor] , an inhibitor of BMP signaling , allowing BMP action only at a distance from their site of synthesis . Positive_regulation CTGF EDN1 15976312 1434716 , via ETA receptor and independently of transforming growth factor-beta , *increases* the [connective tissue growth factor] in vascular smooth muscle cells . Positive_regulation CTGF EDN1 15976312 1434721 Our aim was to investigate whether could *regulate* [CTGF] and to investigate the potential role of ET-1 in vascular fibrosis . Positive_regulation CTGF EDN1 15976312 1434725 The presence of neutralizing transforming growth factor (TGF)-beta antibody did not modify *induced* [CTGF] production , showing a TGF-beta independent regulation . Positive_regulation CTGF EDN1 16336267 1491294 While rapid and sustained CTGF induction was seen following TGF-beta1 treatment , *increased* [CTGF] in a biphasic manner with lower induction at 3 h and a delayed and higher induction after 5 days of permanent ET-1 treatment . Positive_regulation CTGF EDN1 16336267 1491296 Thereby , long-time stimulation by *resulted* in a changed ET-receptor subtype ratio and in a biphasic [CTGF] induction . Positive_regulation CTGF EDN1 17629588 1798551 *stimulated* [CTGF/CCN2] expression in stellate cells but not in hepatocytes . Positive_regulation CTGF EDN1 17681742 1829699 Endogenous signaling *contributes* to type I collagen and [CCN2] overexpression in fibrotic fibroblasts . Positive_regulation CTGF EDN1 18787533 2028370 AZX100 decreased the expression of [CTGF] and type I collagen *induced* by TGF-beta1 , , and lysophosphatidic acid . Positive_regulation CTGF EDN1 19111553 2031722 *induces* [connective tissue growth factor] expression in cardiomyocytes . Positive_regulation CTGF EDN1 19111553 2031728 *activated* the [CTGF] promoter and induced CTGF expression at both mRNA and protein levels . Positive_regulation CTGF EDN1 21611193 2436176 Pharmacological inhibition of the TGFß type I ( ALK5 ) receptor , the A/B receptors and FAK/src significantly *reduced* the induction of [CCN2] and pro-proliferative mRNAs and cell proliferation . Positive_regulation CTGF EDN1 22365964 2681259 Expression of [connective tissue growth factor] , tumor growth factor-ß , collagen I and III in response to AngII *required* endothelial . Positive_regulation CTGF EDN1 24486572 2923615 *induces* [connective tissue growth factor] expression in human lung fibroblasts by ETAR dependent JNK/AP-1 pathway . Positive_regulation CTGF EDN1 24486572 2923617 Moreover , *induced* [CTGF] expression was significantly reduced by JNK inhibitor ( SP600125 ) , the dominant negative mutants of JNK1/2 ( JNK1/2 DN ) , and AP-1 inhibitor ( curcumin ) . Positive_regulation CTGF EDN1 24486572 2923620 We also found that *induced* [CTGF] expression was most controlled by the AP-1 binding region of CTGF promoter . Positive_regulation CTGF EDN1 24486572 2923625 These results suggest that stimulates expressions of CTGF and a-SMA through ETAR/JNK/AP-1 signaling pathway , and [CTGF] is *required* for ET-1 induced a-SMA expression in human lung fibroblasts . Positive_regulation CTGF EDN2 18787533 2028371 AZX100 decreased the expression of [CTGF] and type I collagen *induced* by TGF-beta1 , , and lysophosphatidic acid . Positive_regulation CTGF EDN2 21611193 2436177 Pharmacological inhibition of the TGFß type I ( ALK5 ) receptor , the A/B receptors and FAK/src significantly *reduced* the induction of [CCN2] and pro-proliferative mRNAs and cell proliferation . Positive_regulation CTGF EDN3 18787533 2028372 AZX100 decreased the expression of [CTGF] and type I collagen *induced* by TGF-beta1 , , and lysophosphatidic acid . Positive_regulation CTGF EDN3 21611193 2436178 Pharmacological inhibition of the TGFß type I ( ALK5 ) receptor , the A/B receptors and FAK/src significantly *reduced* the induction of [CCN2] and pro-proliferative mRNAs and cell proliferation . Positive_regulation CTGF EEF1A2 22712078 2616231 The also mitigated subacute anthracycline provoked hepatotoxicity as shown on the level of doxorubicin- and epirubicin *stimulated* [CTGF] mRNA expression as well as histopathologically detectable fibrosis and serum concentration of marker enzymes of hepatotoxicity ( GPT/GLDH ) . Positive_regulation CTGF EGF 11148815 761010 FCS , TGF-beta 1 , TGF-beta 3 , bFGF , and *induced* an upregulation of [CTGF] gene expression in RVEC in a time dependent manner . Positive_regulation CTGF EGF 12787426 1097009 In contrast , platelet derived growth factor ( PDGF ) , , and tumor necrosis factor-alpha (TNF-alpha) *had* no measurable effects on [CTGF] mRNA expression . Positive_regulation CTGF EGF 9790981 542485 By using the ELISA , we confirmed that [CTGF] was specifically *induced* in human fibroblasts by TGF-beta but not by PDGF , FGF , IGF-I , or . Positive_regulation CTGF EGFR 21800344 2509940 Expression of [CTGF] was *stimulated* by ligands and was dependent on the expression of the transcriptional coactivator , Yes associated protein ( YAP ) . Positive_regulation CTGF EGFR 21800344 2509941 We identified elements in the CTGF gene proximal promoter that bound YAP enclosing complexes and were responsible for basal and *stimulated* [CTGF] expression . Positive_regulation CTGF EMD 18052711 1833282 *induced* [CTGF] expression was reduced significantly in the presence of TGF-beta inhibitor . Positive_regulation CTGF EMD 18052711 1833283 *stimulates* [CTGF] expression , and the interaction is modulated via TGF-beta in osteoblastic cells . Positive_regulation CTGF EMD 23951076 2831664 SB431542 also reduced *stimulated* expression of [connective tissue growth factor (CTGF)] , an autocrine inhibitor of adipogenic differentiation . Positive_regulation CTGF ENG 15319534 1286452 These results demonstrate that expression negatively *regulates* basal and TGF-beta1 induced [CTGF] and collagen expression and synthesis . Positive_regulation CTGF ENG 18303046 1878935 Thus , while L-endoglin decreased TGFbeta1 induced collagen I and CTGF expression and increased TGFbeta1 induced proliferation , strongly *increased* TGFbeta1 induced collagen I and [CTGF] expression , and reduced TGFbeta1 induced cell proliferation . Positive_regulation CTGF EPHB2 12234285 988805 , protein kinase C ( PKC ) and tyrosine kinase activity also *contribute* to basal and TGF-beta induced [CTGF] promoter activity in cultured mesangial cells . Positive_regulation CTGF EPHB2 12571253 1071975 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the [CTGF] promoter but not of a generic Smad-responsive promoter ( SBE-lux ) . Positive_regulation CTGF EPHB2 15855807 1425588 TGF-beta1 induced [connective tissue growth factor] ( CCN2 ) expression in human renal proximal tubule epithelial cells *requires* and Smad signalling . Positive_regulation CTGF EPHB2 17474984 1738360 Inhibition of downstream activation decreased TGF-beta *induced* [CTGF] and PAI-1 expression to a basal level . Positive_regulation CTGF EPHB2 17474984 1738362 The data provide evidence that beside the TGF-beta-Smad 3 pathway [CTGF] and PAI-1 expression is additionally *dependent* on activity in hepatocytes giving new insights into regulation of the profibrogenic proteins . Positive_regulation CTGF EPHB2 19194549 2033607 Either JNK or inhibitor did not *block* the hypoxia induced stimulation of [CTGF] , whereas an inhibitor of p38 MAPK reduced the hypoxia induced changes of CTGF . Positive_regulation CTGF EPHB2 19249354 2050982 Differential *requirement* for and SMAD signaling in PAI-1 and [CTGF] expression in response to microtubule disruption . Positive_regulation CTGF EPHB2 20965247 2365229 Finally , we demonstrated that [CTGF] induction in response to LPA *requires* the activation of JNK , but not , signaling pathways . Positive_regulation CTGF EPHB2 24275091 2893159 As ZM447439 increased ERK activity only after 48h , cellular reorganization is likely responsible for triggering the *dependent* upregulation of [CTGF] . Positive_regulation CTGF ESPL1 18583340 1946723 [CTGF] overexpression suppressed Notch signaling and *induced* the transcription of hairy and ( HES)-1 , by Notch independent mechanisms . Positive_regulation CTGF ETS1 16469114 1573954 The induction of [CCN2] by TGFbeta1 *involves* . Positive_regulation CTGF ETS1 16469114 1573956 Endogenous Ets-1 binds this element of the [CCN2] promoter , and dominant negative and specific Ets-1 small interfering RNA block *induction* of CCN2 expression by TGFbeta . Positive_regulation CTGF ETS1 20201953 2259338 Additional experiments showed that [CCN2] *induces* phosphorylation of ERK1/2 , and c-Jun. Consistent with the stimulatory role of ERK1/2/Ets1 in the expression of MMP1 , the ERK1/2 inhibitor UO126 prevented the phosphorylation of ERK1/2 and Ets1 and completely abrogated the induction of MMP1 after CCN2 overexpression , while having no effect on c-Jun activation . Positive_regulation CTGF ETS1 22539964 2590242 is *essential* for connective tissue growth factor ( [CTGF/CCN2] ) induction by TGF-ß1 in osteoblasts . Positive_regulation CTGF ETS1 22539964 2590243 In this study , we investigated the *role* of for [CCN2] induction by TGF-ß1 in primary osteoblasts . Positive_regulation CTGF ETS1 22539964 2590245 This study demonstrates that is an essential downstream signaling component for CCN2 induction by TGF-ß1 in osteoblasts , and that specific EBE sites in the CCN2 promoter are *required* for [CCN2] promoter transactivation in osteoblasts . Positive_regulation CTGF F10 22465921 2578566 Another inhibitor , fondaparinux , *suppressed* urinary protein , glomerular hypertrophy , and [connective tissue growth factor (CTGF)] , and ECM protein deposition together with angiogenesis in diabetic db/db mice . Positive_regulation CTGF FGF2 11148815 761011 FCS , TGF-beta 1 , TGF-beta 3 , , and EGF *induced* an upregulation of [CTGF] gene expression in RVEC in a time dependent manner . Positive_regulation CTGF FGF2 11721179 884019 ( 4 ) Production of [CTGF] in bovine aorta endothelial cells was *induced* by CTGF , VEGF , and TGF-beta . Positive_regulation CTGF FN1 15536170 1374829 [CTGF] ( 20 ng/ml ) *induced* and collagen IV secretion in primary cultures of human proximal tubule cells (PTC) and cortical fibroblasts ( CF ) compared with control values ( P < 0.005 in all cases ) . Positive_regulation CTGF FN1 16528248 1536309 [CTGF] significantly *induced* cell hypertrophy , increased , and collagen IV secretion in PTCs and CFs . Positive_regulation CTGF FN1 22542845 2602930 [CTGF] *induces* TM and a-SMA in animals , whereas actin stress fibers and contractility are both induced in cultured TM cells . Positive_regulation CTGF FOXO1 19208742 2039228 Activation of transcription factors by inhibition of phosphatidylinositol 3-kinase/AKT signaling *resulted* in a synergistic increase in CA-4P mediated [CTGF] induction . Positive_regulation CTGF FOXO1 20018872 2204698 Expression of [CTGF] was strongly *reduced* by siRNA silencing of or FoxO3a . Positive_regulation CTGF FOXO3 19208742 2039229 Activation of transcription factors by inhibition of phosphatidylinositol 3-kinase/AKT signaling *resulted* in a synergistic increase in CA-4P mediated [CTGF] induction . Positive_regulation CTGF FOXO3 20018872 2204699 Expression of [CTGF] was strongly *reduced* by siRNA silencing of FoxO1 or . Positive_regulation CTGF FOXO3 20018872 2204702 Our findings provide evidence that FoxO1 , hypoxia stimulated expression of and its nuclear accumulation are *required* for the induction of [CTGF] by hypoxia in endothelial cells . Positive_regulation CTGF FOXO4 19208742 2039233 Activation of transcription factors by inhibition of phosphatidylinositol 3-kinase/AKT signaling *resulted* in a synergistic increase in CA-4P mediated [CTGF] induction . Positive_regulation CTGF FOXO6 19208742 2039227 Activation of transcription factors by inhibition of phosphatidylinositol 3-kinase/AKT signaling *resulted* in a synergistic increase in CA-4P mediated [CTGF] induction . Positive_regulation CTGF FUT1 12065687 954662 Furthermore , spontaneous activation of plated on plastic and stimulation by vascular endothelial growth factor , lipid peroxidation products ( HNE , MDA ) , acetaldehyde , and platelet derived growth factor (PDGF)-BB significantly *up-regulated* [CTGF] mRNA expression in HSC . Positive_regulation CTGF GDF2 15496414 1347500 RNA interference mediated knockdown of [CTGF] expression significantly diminished *induced* , but not Wnt3A induced , osteogenic differentiation , suggesting that Wnt3A may also regulate osteoblast differentiation in a CTGF independent fashion . Positive_regulation CTGF GLYAT 23141425 2722712 Moreover , EGCG attenuated the excessive expression of [CTGF] *induced* by or AngII , and reduced the nuclear translocation of NF-?B p65 subunit and degradation of I?B-a . Positive_regulation CTGF GNA13 19008857 1998216 The expression of fibrogenic genes ( TGF-beta , [connective tissue growth factor] , and periostin ) and Ang converting enzyme (ACE) was *suppressed* by the functional inhibition of . Positive_regulation CTGF GPER1 19153601 2043245 As the activation of by OHT also *induces* [CTGF] in fibroblasts from breast tumour biopsies , these pathways may be involved in promoting aggressive behaviour of breast tumours in response to endogenous oestrogens or to OHT being used for endocrine therapy . Positive_regulation CTGF GRAP2 16294326 1532367 Inhibitors of ERK1/2 and JNK but not *inhibited* the BK- and AngII stimulated expression of [CTGF] in cells expressing either the WT or mutant receptors , illustrating that ERK and JNK participate in the control of CTGF expression in a manner that appears to be independent of G-protein . Positive_regulation CTGF GRAP2 17786299 1790891 Whereas *mediated* [CTGF] induction by TGFbeta in fibroblasts , MEK/ERK signaling mediated TGFbeta induced CTGF expression in pancreatic cancer cells and was also responsible for basal CTGF expression in pancreatic cancer cell lines with defective Smad signaling . Positive_regulation CTGF GRAP2 20213804 2249216 [CTGF] *induced* phosphorylation of , ERK-1/2 , JNK , and Akt , but not Smad3 , in transgenic mouse fibroblasts compared with wild-type mouse fibroblasts . Positive_regulation CTGF H1F0 16343439 1504083 Adenovirus mediated introduction of c-maf gene into the mouse fibroblast cell line strongly *induced* [CTGF] expression . Positive_regulation CTGF HBZ 21705495 2465702 Finally , expression *resulted* in enhanced transcription of Pdgfb , Sox4 , [Ctgf] , Foxp3 , Runx1 , and Tsc22d1 genes and suppression of the Id2 gene ; Positive_regulation CTGF HGF 18829614 2034586 *induced* a transient expression of [CTGF] , which was maximal after 6 h and returned to baseline after 24 h. Coincubation with TGF-beta increased CTGF protein at 6 h , whereas HGF significantly decreased CTGF induction by TGF-beta after 24 h . Positive_regulation CTGF HGF 18829614 2034588 The PP2 inhibitor of Src-family kinases , which regulate focal adhesion turnover , reduced *mediated* upregulation of [CTGF] . Positive_regulation CTGF HIF1A 19411746 2075274 The may *induce* kidney fibrosis through [CTGF] . Positive_regulation CTGF HRAS 12234285 988806 , protein kinase C ( PKC ) and tyrosine kinase activity also *contribute* to basal and TGF-beta induced [CTGF] promoter activity in cultured mesangial cells . Positive_regulation CTGF HRAS 12571253 1071976 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the [CTGF] promoter but not of a generic Smad-responsive promoter ( SBE-lux ) . Positive_regulation CTGF HRAS 15855807 1425589 TGF-beta1 induced connective tissue growth factor ( [CCN2] ) expression in human renal proximal tubule epithelial cells *requires* and Smad signalling . Positive_regulation CTGF HRAS 15855807 1425656 TGF-beta1 dependent [CCN2] promoter activity was *reduced* by inhibiting and MEK activation . Positive_regulation CTGF IFNG 17376761 1766029 TNF-alpha , but not , *regulates* [CCN2] ( CTGF ) , collagen type I , and proliferation in mesangial cells : possible roles in the progression of renal fibrosis . Positive_regulation CTGF IGF1 9790981 542486 By using the ELISA , we confirmed that [CTGF] was specifically *induced* in human fibroblasts by TGF-beta but not by PDGF , FGF , , or EGF . Positive_regulation CTGF IL13 21804025 2467673 *induces* [connective tissue growth factor] in rat hepatic stellate cells via TGF-ß independent Smad signaling . Positive_regulation CTGF IL13 21804025 2467675 *induces* a time- and dosage dependent increase of [CTGF] in a TGF-ß independent manner . Positive_regulation CTGF IL13 21804025 2467676 Smad1 and Smad2 were identified as the key mediators of *dependent* [CTGF] expression . Positive_regulation CTGF IL13 21804025 2467682 Instead , the Erk1/2-MAPK pathway was found to be responsible for *induced* early Smad phosphorylation and [CTGF] synthesis . Positive_regulation CTGF IL13 21804025 2467691 We demonstrate that *induces* [CTGF] expression in HSCs by activating TGF-ß independent activin receptor-like kinase/Smad signaling via the Erk-MAPK pathway rather than via its canonical JAK/Stat6 pathway . Positive_regulation CTGF IL13 22593760 2598995 In vitro , directly *induces* expression of fibrosis associated genes , e.g. , collagens or [connective tissue growth factor] , in hepatic stellate cells . Positive_regulation CTGF IL1A 23454256 2776318 Signaling pathway inhibitor studies suggested an important role for the p38 MAPK pathway in suppressing [CCN2] expression in *response* to . Positive_regulation CTGF IL1B 17989112 1850953 did not *increase* the production of [CTGF] and type IV collagen but significantly inhibited ANG II-induced CTGF and type IV collagen overexpression . Positive_regulation CTGF IL4 11967989 938060 *regulates* [connective tissue growth factor] expression in human lung fibroblasts . Positive_regulation CTGF IL6 23227240 2708232 [CTGF] *increases* expression in human synovial fibroblasts through integrin dependent signaling pathway . Positive_regulation CTGF ILK 15970428 1497761 Furthermore , stimulation of [CTGF] or thrombospondin by TGFbeta was not *reduced* by deficiency . Positive_regulation CTGF ILK 17498677 1744553 [CTGF] *induced* protein expression in HK-2 cells in a time- and dose dependent manner . Positive_regulation CTGF ILK 17498677 1744559 [CTGF] *induces* the expression of protein in HK-2 cells . Positive_regulation CTGF INHBA 18639630 1954660 Transforming growth factor-beta1 , and tumor necrosis factor-alpha *enhanced* expression of the [CTGF] gene , while interferon-gamma displayed the opposite effect . Positive_regulation CTGF JAK1 23108098 2721401 Thrombin induced CCN2 expression and [CCN2-Luc] activity were *attenuated* by a inhibitor ( AG490 ) and JAK2DN , STAT3DN , and the STAT decoy ODN . Positive_regulation CTGF JAK2 23108098 2721402 Thrombin induced CCN2 expression and [CCN2-Luc] activity were *attenuated* by a inhibitor ( AG490 ) and JAK2DN , STAT3DN , and the STAT decoy ODN . Positive_regulation CTGF JAK3 23108098 2721403 Thrombin induced CCN2 expression and [CCN2-Luc] activity were *attenuated* by a inhibitor ( AG490 ) and JAK2DN , STAT3DN , and the STAT decoy ODN . Positive_regulation CTGF JUN 15780081 1385194 Inhibition of p38 ( mapk ) or p42/44(mapk) activities did not affect LDL induced TGF-beta1 , CTGF , and collagen I expression , whereas inhibition of *suppressed* LDL induced TGF-beta , [CTGF] , and collagen I expression . Positive_regulation CTGF JUN 22212430 2531473 Thrombin acts on PAR-1 to activate the JNK signaling pathway , which in turn initiates activation and ultimately *induces* [CTGF] expression in VSMCs . Positive_regulation CTGF JUN 24486572 2923618 Moreover , ET-1 induced [CTGF] expression was significantly *reduced* by JNK inhibitor ( SP600125 ) , the dominant negative mutants of JNK1/2 ( JNK1/2 DN ) , and inhibitor ( curcumin ) . Positive_regulation CTGF KLF15 18586263 1946833 Adenoviral overexpression of *inhibits* basal and TGFbeta1 induced [CTGF] expression in NRVFs . Positive_regulation CTGF KLF15 24356553 2881432 Our in vitro evidence showed that overexpression of *repressed* basal and transforming growth factor-ß1 ( TGF-ß1 ) -induced extracellular matrix and [CTGF] in NRK-49F cells . Positive_regulation CTGF KRAS 12234285 988807 , protein kinase C ( PKC ) and tyrosine kinase activity also *contribute* to basal and TGF-beta induced [CTGF] promoter activity in cultured mesangial cells . Positive_regulation CTGF KRAS 12571253 1071977 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the [CTGF] promoter but not of a generic Smad-responsive promoter ( SBE-lux ) . Positive_regulation CTGF KRAS 15855807 1425590 TGF-beta1 induced [connective tissue growth factor] ( CCN2 ) expression in human renal proximal tubule epithelial cells *requires* and Smad signalling . Positive_regulation CTGF KRAS 15855807 1425657 TGF-beta1 dependent [CCN2] promoter activity was *reduced* by inhibiting and MEK activation . Positive_regulation CTGF LDLR 15469966 1342390 Tyrosine phosphorylation of the and activation of the ERK pathway are *required* for [connective tissue growth factor] to potentiate myofibroblast differentiation . Positive_regulation CTGF LEF1 20571031 2308991 On the other hand , the same assays showed that in hypertrophic chondrocytes , LEF x beta-catenin complexes occupy the consensus TCF x LEF x Sox9 site and *activate* [Ccn2] expression . Positive_regulation CTGF LEP 15389880 1324290 Additionally , AGE induced mitogenesis and type I collagen protein expression were dependent on *induced* [CTGF] . Positive_regulation CTGF LEP 17976159 1866741 *stimulated* [CTGF] synthesis in LX-2 cells . Positive_regulation CTGF LEP 18715880 1979823 *up-regulated* the expression of [connective tissue growth factor] , villin 2 , and basigin , factors that are associated with ECM and are known to impact tumor growth . Positive_regulation CTGF LPA 10976101 751901 In contrast to the induction of other early response genes ( Egr-1 and cyclooxygenase-2 ) , *mediated* induction of [CTGF] was pertussis toxin-insensitive and independent of p42/44 MAP kinase activation . Positive_regulation CTGF LPA 10976101 751929 Inhibition of the downstream mediator of RhoA , the Rho kinase by Y-27632 partially reduced *induction* of [CTGF] by and TGF-beta . Positive_regulation CTGF LPA 11518778 851717 *induced* a rapid transient increase in [CTGF] mRNA expression , with maximal levels being observed after 1 to 2 h . Positive_regulation CTGF LPA 11518778 851719 Inhibition of the proteins of the Rho family with toxin B from Clostridium difficile abrogated basal and *mediated* induction of [CTGF] . Positive_regulation CTGF LPA 11518778 851720 Inhibition of RhoA depolymerized the actin cytoskeleton , as did treatment with cytochalasin D. Preincubation of the human renal fibroblasts with cytochalasin D prevented *induction* of [CTGF] by , indicating a strong contribution of an intact cytoskeleton . Positive_regulation CTGF LPA 15262182 1274630 Up-regulation of [CTGF] in endothelial cells , *induced* by , S1P , or platelets , may contribute to the initiation and progression of atherosclerosis . Positive_regulation CTGF LPA 15780081 1385168 Evidence for low-density *induced* expression of [connective tissue growth factor] in mesangial cells . Positive_regulation CTGF LPA 15970428 1497759 However , *induction* of [CTGF] expression by or colchicine was comparable in ILK ( +/+ ) and ILK ( -/- ) cells . Positive_regulation CTGF LPA 16272194 1532154 Mechanisms of low-density *induced* expression of [connective tissue growth factor] in human aortic endothelial cells . Positive_regulation CTGF LPA 16707113 1570207 Inhibition of Src family kinases with PP2 , but not the inactive analogue PP3 , also interfered with mediated tyrosine phosphorylation and *induction* of [CTGF] . Positive_regulation CTGF LPA 18003779 1827174 In vitro , *induced* a rapid , dose dependent increase in [CTGF] expression that was inhibited by Ki16425 . Positive_regulation CTGF LPA 20965247 2365227 In the absence of TGF-ß , the *induction* of [CTGF] expression by was abolished by a dominant negative form of the TGF-ß receptor type II ( TGF-ßRII ) and by the use of SB 431542 , a specific inhibitor of the serine/threonine kinase activity of TGF-ßRI , suggesting that CTGF induction is dependent on LPA and requires active TGF-ßRs . Positive_regulation CTGF LPA 20965247 2365228 Moreover , we show that *requires* Smad-2/3 proteins for the induction of [CTGF] expression , but not their phosphorylation or their nuclear translocation . Positive_regulation CTGF LPA 20965247 2365230 Finally , we demonstrated that [CTGF] induction in *response* to requires the activation of JNK , but not ERK , signaling pathways . Positive_regulation CTGF LPA 21545790 2435334 In vitro , *induced* both fibroblast proliferation and [CTGF] expression in a dose dependent manner , and both were suppressed by blockade of LPAR1/3 . Positive_regulation CTGF LPA 22422617 2588063 Low-density *induced* expression of [connective tissue growth factor] via transactivation of sphingosine 1-phosphate receptors in mesangial cells . Positive_regulation CTGF LPA 22922058 2683182 It was demonstrated that stimulation in many cell types such as human endothelial cells , human renal fibroblasts , and myoblasts , significantly *upregulates* [connective tissue growth factor (CTGF)] expression , which acts as a downstream signaling effector for transforming growth factor-ß1 ( TGF-ß1 ) to drive fibrosis . Positive_regulation CTGF LPAR1 18455518 1951567 Furthermore , in renal fibrosis activation *stimulates* macrophage recruitment and [connective tissue growth factor] expression . Positive_regulation CTGF LPAR1 23322166 2775460 Activation of on mesothelial cells *induced* these cells to express [connective tissue growth factor (CTGF)] , driving fibroblast proliferation in a paracrine fashion . Positive_regulation CTGF MAF 16343439 1504084 however , the c-Maf could not induce TGF-beta , nor could TGF-beta induce the c-Maf , suggesting that *activation* of [CTGF] by is TGF-beta independent . Positive_regulation CTGF MAP2K1 12234285 988808 , protein kinase C ( PKC ) and tyrosine kinase activity also *contribute* to basal and TGF-beta induced [CTGF] promoter activity in cultured mesangial cells . Positive_regulation CTGF MAP2K1 12571253 1071978 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the [CTGF] promoter but not of a generic Smad-responsive promoter ( SBE-lux ) . Positive_regulation CTGF MAP2K1 15855807 1425599 TGF-beta1 induced connective tissue growth factor ( [CCN2] ) expression in human renal proximal tubule epithelial cells *requires* and Smad signalling . Positive_regulation CTGF MAP2K1 15855807 1425658 TGF-beta1 dependent [CCN2] promoter activity was *reduced* by inhibiting Ras and activation . Positive_regulation CTGF MAP2K1 15955090 1422001 Furthermore , co-expression of Smad3 with constitutively active *resulted* in potent induction of [CTGF] production without exogenous TGF-beta stimulation . Positive_regulation CTGF MAP2K1 18481199 1840513 Overexpressing constitutively active or ras *activated* [CCN2] promoter activity . Positive_regulation CTGF MAP2K1 19249354 2050991 Differential *requirement* for and SMAD signaling in PAI-1 and [CTGF] expression in response to microtubule disruption . Positive_regulation CTGF MAP2K1 23415771 2764665 In addition , inhibitors U0126 or PD98059 , but not mTOR specific inhibitors , rapamycin and Torin 1 , *inhibited* rPMT induced upregulation of [CTGF] . Positive_regulation CTGF MAP2K2 12234285 988809 , protein kinase C ( PKC ) and tyrosine kinase activity also *contribute* to basal and TGF-beta induced [CTGF] promoter activity in cultured mesangial cells . Positive_regulation CTGF MAP2K2 12571253 1071979 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the [CTGF] promoter but not of a generic Smad-responsive promoter ( SBE-lux ) . Positive_regulation CTGF MAP2K2 15855807 1425600 TGF-beta1 induced [connective tissue growth factor] ( CCN2 ) expression in human renal proximal tubule epithelial cells *requires* and Smad signalling . Positive_regulation CTGF MAP2K2 15855807 1425659 TGF-beta1 dependent [CCN2] promoter activity was *reduced* by inhibiting Ras and activation . Positive_regulation CTGF MAP2K2 19249354 2050992 Differential *requirement* for and SMAD signaling in PAI-1 and [CTGF] expression in response to microtubule disruption . Positive_regulation CTGF MAP2K2 23415771 2764666 In addition , inhibitors U0126 or PD98059 , but not mTOR specific inhibitors , rapamycin and Torin 1 , *inhibited* rPMT induced upregulation of [CTGF] . Positive_regulation CTGF MAP2K3 12234285 988810 , protein kinase C ( PKC ) and tyrosine kinase activity also *contribute* to basal and TGF-beta induced [CTGF] promoter activity in cultured mesangial cells . Positive_regulation CTGF MAP2K3 12571253 1071980 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the [CTGF] promoter but not of a generic Smad-responsive promoter ( SBE-lux ) . Positive_regulation CTGF MAP2K3 15855807 1425601 TGF-beta1 induced connective tissue growth factor ( [CCN2] ) expression in human renal proximal tubule epithelial cells *requires* and Smad signalling . Positive_regulation CTGF MAP2K3 15855807 1425660 TGF-beta1 dependent [CCN2] promoter activity was *reduced* by inhibiting Ras and activation . Positive_regulation CTGF MAP2K3 19249354 2050993 Differential *requirement* for and SMAD signaling in PAI-1 and [CTGF] expression in response to microtubule disruption . Positive_regulation CTGF MAP2K3 23415771 2764667 In addition , inhibitors U0126 or PD98059 , but not mTOR specific inhibitors , rapamycin and Torin 1 , *inhibited* rPMT induced upregulation of [CTGF] . Positive_regulation CTGF MAP2K4 12234285 988811 , protein kinase C ( PKC ) and tyrosine kinase activity also *contribute* to basal and TGF-beta induced [CTGF] promoter activity in cultured mesangial cells . Positive_regulation CTGF MAP2K4 12571253 1071981 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the [CTGF] promoter but not of a generic Smad-responsive promoter ( SBE-lux ) . Positive_regulation CTGF MAP2K4 15855807 1425602 TGF-beta1 induced [connective tissue growth factor] ( CCN2 ) expression in human renal proximal tubule epithelial cells *requires* and Smad signalling . Positive_regulation CTGF MAP2K4 15855807 1425661 TGF-beta1 dependent [CCN2] promoter activity was *reduced* by inhibiting Ras and activation . Positive_regulation CTGF MAP2K4 19249354 2050994 Differential *requirement* for and SMAD signaling in PAI-1 and [CTGF] expression in response to microtubule disruption . Positive_regulation CTGF MAP2K4 23415771 2764668 In addition , inhibitors U0126 or PD98059 , but not mTOR specific inhibitors , rapamycin and Torin 1 , *inhibited* rPMT induced upregulation of [CTGF] . Positive_regulation CTGF MAP2K5 12234285 988812 , protein kinase C ( PKC ) and tyrosine kinase activity also *contribute* to basal and TGF-beta induced [CTGF] promoter activity in cultured mesangial cells . Positive_regulation CTGF MAP2K5 12571253 1071982 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the [CTGF] promoter but not of a generic Smad-responsive promoter ( SBE-lux ) . Positive_regulation CTGF MAP2K5 15855807 1425603 TGF-beta1 induced connective tissue growth factor ( [CCN2] ) expression in human renal proximal tubule epithelial cells *requires* and Smad signalling . Positive_regulation CTGF MAP2K5 15855807 1425662 TGF-beta1 dependent [CCN2] promoter activity was *reduced* by inhibiting Ras and activation . Positive_regulation CTGF MAP2K5 19249354 2050995 Differential *requirement* for and SMAD signaling in PAI-1 and [CTGF] expression in response to microtubule disruption . Positive_regulation CTGF MAP2K5 23415771 2764669 In addition , inhibitors U0126 or PD98059 , but not mTOR specific inhibitors , rapamycin and Torin 1 , *inhibited* rPMT induced upregulation of [CTGF] . Positive_regulation CTGF MAP2K6 12234285 988813 , protein kinase C ( PKC ) and tyrosine kinase activity also *contribute* to basal and TGF-beta induced [CTGF] promoter activity in cultured mesangial cells . Positive_regulation CTGF MAP2K6 12571253 1071983 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the [CTGF] promoter but not of a generic Smad-responsive promoter ( SBE-lux ) . Positive_regulation CTGF MAP2K6 15855807 1425604 TGF-beta1 induced [connective tissue growth factor] ( CCN2 ) expression in human renal proximal tubule epithelial cells *requires* and Smad signalling . Positive_regulation CTGF MAP2K6 15855807 1425663 TGF-beta1 dependent [CCN2] promoter activity was *reduced* by inhibiting Ras and activation . Positive_regulation CTGF MAP2K6 19249354 2050996 Differential *requirement* for and SMAD signaling in PAI-1 and [CTGF] expression in response to microtubule disruption . Positive_regulation CTGF MAP2K6 23415771 2764670 In addition , inhibitors U0126 or PD98059 , but not mTOR specific inhibitors , rapamycin and Torin 1 , *inhibited* rPMT induced upregulation of [CTGF] . Positive_regulation CTGF MAP2K7 12234285 988814 , protein kinase C ( PKC ) and tyrosine kinase activity also *contribute* to basal and TGF-beta induced [CTGF] promoter activity in cultured mesangial cells . Positive_regulation CTGF MAP2K7 12571253 1071984 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the [CTGF] promoter but not of a generic Smad-responsive promoter ( SBE-lux ) . Positive_regulation CTGF MAP2K7 15855807 1425605 TGF-beta1 induced connective tissue growth factor ( [CCN2] ) expression in human renal proximal tubule epithelial cells *requires* and Smad signalling . Positive_regulation CTGF MAP2K7 15855807 1425664 TGF-beta1 dependent [CCN2] promoter activity was *reduced* by inhibiting Ras and activation . Positive_regulation CTGF MAP2K7 19249354 2050997 Differential *requirement* for and SMAD signaling in PAI-1 and [CTGF] expression in response to microtubule disruption . Positive_regulation CTGF MAP2K7 23415771 2764671 In addition , inhibitors U0126 or PD98059 , but not mTOR specific inhibitors , rapamycin and Torin 1 , *inhibited* rPMT induced upregulation of [CTGF] . Positive_regulation CTGF MAPK1 12218048 1012102 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Positive_regulation CTGF MAPK1 16294326 1532368 Inhibitors of ERK1/2 and JNK but not *inhibited* the BK- and AngII stimulated expression of [CTGF] in cells expressing either the WT or mutant receptors , illustrating that ERK and JNK participate in the control of CTGF expression in a manner that appears to be independent of G-protein . Positive_regulation CTGF MAPK1 17212361 1724735 Glucose and insulin induced phosphorylation also *stimulated* [connective tissue growth factor] gene expression . Positive_regulation CTGF MAPK1 17592071 1768146 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Positive_regulation CTGF MAPK1 20213804 2249218 [CTGF] *induced* phosphorylation of p38 , , JNK , and Akt , but not Smad3 , in transgenic mouse fibroblasts compared with wild-type mouse fibroblasts . Positive_regulation CTGF MAPK10 12218048 1012103 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Positive_regulation CTGF MAPK10 16294326 1532369 Inhibitors of ERK1/2 and JNK but not *inhibited* the BK- and AngII stimulated expression of [CTGF] in cells expressing either the WT or mutant receptors , illustrating that ERK and JNK participate in the control of CTGF expression in a manner that appears to be independent of G-protein . Positive_regulation CTGF MAPK10 17592071 1768147 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Positive_regulation CTGF MAPK11 12218048 1012104 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Positive_regulation CTGF MAPK11 16294326 1532370 Inhibitors of ERK1/2 and JNK but not *inhibited* the BK- and AngII stimulated expression of [CTGF] in cells expressing either the WT or mutant receptors , illustrating that ERK and JNK participate in the control of CTGF expression in a manner that appears to be independent of G-protein . Positive_regulation CTGF MAPK11 17592071 1768148 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Positive_regulation CTGF MAPK12 12218048 1012105 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Positive_regulation CTGF MAPK12 16294326 1532371 Inhibitors of ERK1/2 and JNK but not *inhibited* the BK- and AngII stimulated expression of [CTGF] in cells expressing either the WT or mutant receptors , illustrating that ERK and JNK participate in the control of CTGF expression in a manner that appears to be independent of G-protein . Positive_regulation CTGF MAPK12 17592071 1768149 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Positive_regulation CTGF MAPK13 12218048 1012106 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Positive_regulation CTGF MAPK13 16294326 1532372 Inhibitors of ERK1/2 and JNK but not *inhibited* the BK- and AngII stimulated expression of [CTGF] in cells expressing either the WT or mutant receptors , illustrating that ERK and JNK participate in the control of CTGF expression in a manner that appears to be independent of G-protein . Positive_regulation CTGF MAPK13 17592071 1768150 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Positive_regulation CTGF MAPK14 12218048 1012107 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Positive_regulation CTGF MAPK14 16294326 1532373 Inhibitors of ERK1/2 and JNK but not *inhibited* the BK- and AngII stimulated expression of [CTGF] in cells expressing either the WT or mutant receptors , illustrating that ERK and JNK participate in the control of CTGF expression in a manner that appears to be independent of G-protein . Positive_regulation CTGF MAPK14 17592071 1768151 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Positive_regulation CTGF MAPK15 12218048 1012098 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Positive_regulation CTGF MAPK15 16294326 1532366 Inhibitors of ERK1/2 and JNK but not *inhibited* the BK- and AngII stimulated expression of [CTGF] in cells expressing either the WT or mutant receptors , illustrating that ERK and JNK participate in the control of CTGF expression in a manner that appears to be independent of G-protein . Positive_regulation CTGF MAPK15 17592071 1768145 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Positive_regulation CTGF MAPK3 12218048 1012108 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Positive_regulation CTGF MAPK3 16294326 1532374 Inhibitors of ERK1/2 and JNK but not *inhibited* the BK- and AngII stimulated expression of [CTGF] in cells expressing either the WT or mutant receptors , illustrating that ERK and JNK participate in the control of CTGF expression in a manner that appears to be independent of G-protein . Positive_regulation CTGF MAPK3 16813525 1580697 [CCN2] was critically involved in osteolytic metastasis and was *induced* by PKA- and PKC dependent activation of signaling by PTHrP . Positive_regulation CTGF MAPK3 17212361 1724736 Glucose and insulin induced phosphorylation also *stimulated* [connective tissue growth factor] gene expression . Positive_regulation CTGF MAPK3 17592071 1768152 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Positive_regulation CTGF MAPK3 20213804 2249219 [CTGF] *induced* phosphorylation of p38 , , JNK , and Akt , but not Smad3 , in transgenic mouse fibroblasts compared with wild-type mouse fibroblasts . Positive_regulation CTGF MAPK4 12218048 1012109 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Positive_regulation CTGF MAPK4 16294326 1532375 Inhibitors of ERK1/2 and JNK but not *inhibited* the BK- and AngII stimulated expression of [CTGF] in cells expressing either the WT or mutant receptors , illustrating that ERK and JNK participate in the control of CTGF expression in a manner that appears to be independent of G-protein . Positive_regulation CTGF MAPK4 17592071 1768153 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Positive_regulation CTGF MAPK6 12218048 1012110 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Positive_regulation CTGF MAPK6 16294326 1532376 Inhibitors of ERK1/2 and JNK but not *inhibited* the BK- and AngII stimulated expression of [CTGF] in cells expressing either the WT or mutant receptors , illustrating that ERK and JNK participate in the control of CTGF expression in a manner that appears to be independent of G-protein . Positive_regulation CTGF MAPK6 17592071 1768154 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Positive_regulation CTGF MAPK7 12218048 1012111 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Positive_regulation CTGF MAPK7 16294326 1532377 Inhibitors of ERK1/2 and JNK but not *inhibited* the BK- and AngII stimulated expression of [CTGF] in cells expressing either the WT or mutant receptors , illustrating that ERK and JNK participate in the control of CTGF expression in a manner that appears to be independent of G-protein . Positive_regulation CTGF MAPK7 17592071 1768155 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Positive_regulation CTGF MAPK8 12218048 1012112 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Positive_regulation CTGF MAPK8 16294326 1532378 Inhibitors of ERK1/2 and JNK but not *inhibited* the BK- and AngII stimulated expression of [CTGF] in cells expressing either the WT or mutant receptors , illustrating that ERK and JNK participate in the control of CTGF expression in a manner that appears to be independent of G-protein . Positive_regulation CTGF MAPK8 17592071 1768156 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Positive_regulation CTGF MAPK8 18287089 1891398 We previously demonstrated that phosphorylation by TGFbeta1 is also *critical* for TGFbeta1 induced [CCN2/CTGF] expression , and forskolin partially reduces levels of phosphorylated JNK1 . Positive_regulation CTGF MAPK9 12218048 1012113 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Positive_regulation CTGF MAPK9 16294326 1532379 Inhibitors of ERK1/2 and JNK but not *inhibited* the BK- and AngII stimulated expression of [CTGF] in cells expressing either the WT or mutant receptors , illustrating that ERK and JNK participate in the control of CTGF expression in a manner that appears to be independent of G-protein . Positive_regulation CTGF MAPK9 17592071 1768157 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Positive_regulation CTGF MBTPS1 15192102 1281004 Furthermore , the expression of [connective tissue growth factor] is *enhanced* by both TGF-beta(2) and . Positive_regulation CTGF MBTPS1 15262182 1274629 Up-regulation of [CTGF] in endothelial cells , *induced* by LPA , , or platelets , may contribute to the initiation and progression of atherosclerosis . Positive_regulation CTGF MBTPS1 15862293 1400934 We recently reported that *induces* [CTGF] expression in rat cultured mesangial cells . Positive_regulation CTGF MBTPS1 15862293 1400936 However , the mechanism by which *induces* [CTGF] expression is unknown . Positive_regulation CTGF MBTPS1 15862293 1400937 The present study revealed that *induced* [CTGF] expression is mediated via pertussis toxin-insensitive pathways , which are involved in the activation of small GTPases of the Rho family and protein kinase C . Positive_regulation CTGF MBTPS1 15862293 1400939 We also showed by luciferase reporter assays and chromatin immunoprecipitation that *induces* [CTGF] expression via Smad activation as TGF-beta does . Positive_regulation CTGF MBTPS1 18922980 1977411 Further , the specific S1P2 antagonist JTE-013 completely inhibited *induced* [CTGF] expression , whereas the S1P1 antagonist VPC44116 did not , indicating that this effect was mediated by S1P2 . Positive_regulation CTGF MBTPS1 18922980 1977412 *Induction* of [CTGF] by was sensitive to ROCK inhibitor Y-27632 and c-Jun NH2-terminal kinase inhibitor SP600125 , suggesting the requirement of RhoA/ROCK and c-Jun NH2-terminal kinase pathways for S1P induced CTGF expression . Positive_regulation CTGF MBTPS1 21829623 2468191 Functionally , disruption of receptor signaling by S1P depletion *inhibited* proliferation and expression of [connective tissue growth factor] in mesangial cells , proliferation , migration and VEGF expression in carcinoma cells , and proliferation and migration of endothelial cells . Positive_regulation CTGF MBTPS1 22422617 2588078 Furthermore , stimulation *induced* expression of [CTGF] in a dose dependent manner that was markedly inhibited by blocking the ERK1/2 and JNK signaling pathways . Positive_regulation CTGF MBTPS1 22422617 2588081 Our data suggest that SK1 dependent receptor transactivation is upstream of ERK1/2 and JNK and that all three steps are *required* for LDL regulated expression of [CTGF] in mesangial cells . Positive_regulation CTGF MED1 10976101 751931 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED10 10976101 751925 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED11 10976101 751928 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED13 10976101 751912 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED13L 10976101 751913 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED14 10976101 751917 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED15 10976101 751906 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED16 10976101 751908 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED17 10976101 751919 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED18 10976101 751924 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED19 10976101 751927 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED20 10976101 751907 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED21 10976101 751904 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED22 10976101 751905 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED23 10976101 751918 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED24 10976101 751914 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED25 10976101 751926 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED26 10976101 751920 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED27 10976101 751921 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED29 10976101 751916 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED30 10976101 751915 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED31 10976101 751923 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED4 10976101 751909 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED6 10976101 751910 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED7 10976101 751922 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MED8 10976101 751911 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF MIR18A 21501375 2475556 and microRNA-19 *regulate* [CTGF] and TSP-1 expression in age related heart failure . Positive_regulation CTGF MMP1 17907155 1812573 Inhibition of MMP activity by MMP inhibitor GM1489 and inhibition of expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity , but significantly *restored* HGF inhibited collagen and [CTGF] accumulation . Positive_regulation CTGF MMP14 20079746 2218705 These changes were accompanied by evidence of local RAAS activation , increased expression of [connective tissue growth factor (CTGF)] and TGF-beta1 , and a significant *activation* of MMP-2 and . Positive_regulation CTGF MMP2 15144592 1247590 While cells were stimulated for 48 hours , 100 ng/ml [CTGF] and 5 ng/ml TGF- beta(1) *induce* a increase in activity and protein levels compared with vechile , respectively ( P < 0.05 ) ; Positive_regulation CTGF MMP2 20079746 2218706 These changes were accompanied by evidence of local RAAS activation , increased expression of [connective tissue growth factor (CTGF)] and TGF-beta1 , and a significant *activation* of and MT1-MMP . Positive_regulation CTGF MMP2 23048035 2702757 [CTGF/CCN2] effects on abnormal vessel formation in the retina are *mediated* by p53 and . Positive_regulation CTGF MMP3 18172013 1875583 Novel transcription-factor-like function of human *regulating* the [CTGF/CCN2] gene . Positive_regulation CTGF MMP3 18172013 1875596 The [CCN2/CTGF] promoter was *activated* by overexpressed , whereas a TRENDIC mutant promoter lost the response . Positive_regulation CTGF MMP3 22134873 2599624 The MMP-3 inhibitor NNGH failed to suppress *induced* [CTGF/CCN2] protein expression . Positive_regulation CTGF MMP3 22134873 2599625 The potent dynamin inhibitor dynasore clearly inhibited *induced* [CTGF/CCN2] expression . Positive_regulation CTGF MMP3 22134873 2599626 These results strongly suggest that *induces* [CTGF/CCN2] production independently of the protease activity of MMP-3 and dependently on dynamin related endocytosis , which is involved in cell migration in human dental pulp cells . Positive_regulation CTGF MTOR 23415771 2764664 In addition , MEK inhibitors U0126 or PD98059 , but not specific inhibitors , rapamycin and Torin 1 , *inhibited* rPMT induced upregulation of [CTGF] . Positive_regulation CTGF MUC1 20697347 2335456 CT for *induced* [CTGF] expression and demonstrate a phosphorylation-specific localization of MUC1 . Positive_regulation CTGF MYLIP 19096030 2031137 and miR-30 *regulate* [connective tissue growth factor] : implications for a role of microRNAs in myocardial matrix remodeling . Positive_regulation CTGF MYLIP 21927029 2591591 Ectopic *increased* migration and invasion in [SAS/CTGF-M3] , however , miR-346 did not have such impact on migration/invasion . Positive_regulation CTGF MYLIP 24185621 2890156 Importantly , and miR-18b were directly *involved* in the post-transcriptional regulation of collagen IV alpha 1 (Col4a1) and [connective tissue growth factor (CTGF)] in EWS knock-out ( KO ) mouse embryonic fibroblast cells . Positive_regulation CTGF MYLIP 24296617 2904762 The *role* of in the regulation of Ang II-induced [CTGF] expression was evaluated in cultured cardiomyocytes with quantitative real-time reverse transcription polymerase chain reaction and Western blot analysis . Positive_regulation CTGF MYLIP 24296617 2904770 Downregulation of *contributes* to Ang II-induced overexpression of [CTGF] in cultured cardiomyocytes . Positive_regulation CTGF NFKB1 16303051 1490772 *Activation* of by [connective tissue growth factor] ( CCN2 ) is involved in sustaining the survival of primary rat hepatic stellate cells . Positive_regulation CTGF NFKB1 16707502 1584470 Thus , mechanical stretch induced changes in actin dynamics mediate activation and *induce* [CCN2] gene expression , which probably initiates the fibrotic reactions observed in mechanical overload associated pathologies . Positive_regulation CTGF NFKB1 20409024 2274281 A pharmacological inhibitor of , MG132 , *inhibited* LPS induced [CTGF] mRNA expression . Positive_regulation CTGF NOV 21748432 2546608 We further found that adenoviral overexpression of CCN2/CTGF suppressed CCN3/NOV expression , while the overexpression of as well as the suppression of CCN3/NOV by targeting siRNAs both *resulted* in enhanced [CCN2/CTGF] expression . Positive_regulation CTGF NOV 22698069 2659327 Furthermore , overexpressed in cultured primary hepatocytes *resulted* in decreased levels of [CCN2/CTGF] , the profibrotic marker protein in liver fibrosis . Positive_regulation CTGF NOX1 16612258 1546586 CsA induced myocardial ANP and [connective tissue growth factor (CTGF)] mRNA overexpression , RAS activation , *induction* , and NRF2 overexpression were prevented by LA . Positive_regulation CTGF NOX3 16612258 1546587 CsA induced myocardial ANP and [connective tissue growth factor (CTGF)] mRNA overexpression , RAS activation , *induction* , and NRF2 overexpression were prevented by LA . Positive_regulation CTGF NOX4 16612258 1546588 CsA induced myocardial ANP and [connective tissue growth factor (CTGF)] mRNA overexpression , RAS activation , *induction* , and NRF2 overexpression were prevented by LA . Positive_regulation CTGF NOX5 16612258 1546585 CsA induced myocardial ANP and [connective tissue growth factor (CTGF)] mRNA overexpression , RAS activation , *induction* , and NRF2 overexpression were prevented by LA . Positive_regulation CTGF NPY6R 18829614 2034589 The inhibitor of Src-family kinases , which regulate focal adhesion turnover , *reduced* HGF mediated upregulation of [CTGF] . Positive_regulation CTGF NR3C2 17602195 1815908 [CTGF] is a functional target of aldosterone in mesangial cells , but aldosterone induced CTGF gene expression is not directly *mediated* by the . Positive_regulation CTGF NR4A1 7593235 334629 , PAI-1 , and HSP-70 were induced or stimulated only in cells at the wound edge , u-PA was stimulated in cells away from the wound , and [CTGF] was *induced* in each of these populations suggesting that cell-to-cell communication may regulate gene expression after wounding . Positive_regulation CTGF NRAS 12234285 988815 , protein kinase C ( PKC ) and tyrosine kinase activity also *contribute* to basal and TGF-beta induced [CTGF] promoter activity in cultured mesangial cells . Positive_regulation CTGF NRAS 12571253 1071985 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the [CTGF] promoter but not of a generic Smad-responsive promoter ( SBE-lux ) . Positive_regulation CTGF NRAS 15855807 1425606 TGF-beta1 induced [connective tissue growth factor] ( CCN2 ) expression in human renal proximal tubule epithelial cells *requires* and Smad signalling . Positive_regulation CTGF NRAS 15855807 1425665 TGF-beta1 dependent [CCN2] promoter activity was *reduced* by inhibiting and MEK activation . Positive_regulation CTGF NRAS 19494553 2098074 Only inhibition of *resulted* in a significant reduction of auto induced TGFbeta1 secretion and TGFbeta1 induced cellular and secreted [CTGF] . Positive_regulation CTGF NRG1 22350758 2586822 *induces* [CTGF] expression in hypertrophic scarring fibroblasts . Positive_regulation CTGF NRG1 22350758 2586829 Furthermore , stimulation *increased* the expression of [CTGF] in HTSF . Positive_regulation CTGF NRG2 22350758 2586823 *induces* [CTGF] expression in hypertrophic scarring fibroblasts . Positive_regulation CTGF NRG3 22350758 2586824 *induces* [CTGF] expression in hypertrophic scarring fibroblasts . Positive_regulation CTGF NRG4 22350758 2586821 *induces* [CTGF] expression in hypertrophic scarring fibroblasts . Positive_regulation CTGF OPA1 10976101 751930 Inhibition of the downstream of RhoA , the Rho kinase by Y-27632 partially *reduced* induction of [CTGF] by LPA and TGF-beta . Positive_regulation CTGF OSM 22814105 2640030 In the present study we examined the *role* of TGF-ß1- and induced signaling mechanisms in the regulation of [CTGF] mRNA expression in human proximal tubular HK-2 cells . Positive_regulation CTGF OSM 22814105 2640032 While *led* to a rapid and transient induction of [CTGF] mRNA expression between 15 min and 1h of stimulation it markedly suppressed basal and TGF-ß1 induced CTGF mRNA levels thereafter . Positive_regulation CTGF PAPSS1 22422617 2588082 Our data suggest that dependent S1P receptor transactivation is upstream of ERK1/2 and JNK and that all three steps are *required* for LDL regulated expression of [CTGF] in mesangial cells . Positive_regulation CTGF PARP1 18287562 1896592 *enhances* transcription of the profibrotic [CCN2] gene . Positive_regulation CTGF PGF 12724323 1106570 Using Affymetrix gene chip technology , we first identified that dramatically *up-regulated* Cyr61 and [CTGF] mRNA expression in HEK 293/EBNA cells ( hFP-HEK 293/EBNA ) . Positive_regulation CTGF PI3 11018037 752831 VEGF induced [CTGF] expression was *mediated* primarily by activation , whereas PKC and ERK pathways made only minimal contributions . Positive_regulation CTGF PI3 12760970 1091438 On the other hand , specific inhibitors of *suppressed* TGF-beta1 induced [CTGF] expression in a concentration dependent manner . Positive_regulation CTGF PIK3CA 19208742 2039234 Activation of FoxO transcription factors by inhibition of signaling *resulted* in a synergistic increase in CA-4P mediated [CTGF] induction . Positive_regulation CTGF PIK3CA 21865737 2473488 Specific inhibitors of *suppressed* stretch -induced [CTGF] expression in a time dependent manner . Positive_regulation CTGF PIK3CA 22350758 2586838 In the *presence* of inhibitors of , Src , Smad , or reactive oxygen species , the effect of NRG1 on [CTGF] expression decreased significantly . Positive_regulation CTGF PIK3CA 23824844 2838929 Data indicate that inhibitors *attenuate* upregulation of TGF-ß1 induced [CCN2/CTGF] expression in human gingival fibroblasts independent of reducing JNK MAP kinase activation . Positive_regulation CTGF PIK3R1 19208742 2039235 Activation of FoxO transcription factors by inhibition of signaling *resulted* in a synergistic increase in CA-4P mediated [CTGF] induction . Positive_regulation CTGF PIK3R1 21865737 2473489 Specific inhibitors of *suppressed* stretch -induced [CTGF] expression in a time dependent manner . Positive_regulation CTGF PIK3R1 22350758 2586839 In the *presence* of inhibitors of , Src , Smad , or reactive oxygen species , the effect of NRG1 on [CTGF] expression decreased significantly . Positive_regulation CTGF PIK3R1 23824844 2838930 Data indicate that inhibitors *attenuate* upregulation of TGF-ß1 induced [CCN2/CTGF] expression in human gingival fibroblasts independent of reducing JNK MAP kinase activation . Positive_regulation CTGF PLG 15743758 1396790 Expression of Smad3 did not stimulate type II collagen synthesis or enhance that caused by TGF-beta1 or TAK1a , in contrast to its effects on its endogenous targets , [CTGF] and *activated* inhibitor-1 . Positive_regulation CTGF PPARG 16723090 1565395 inhibits growth of rat hepatic stellate cells and TGF beta *induced* [connective tissue growth factor] expression . Positive_regulation CTGF PRDX2 19404935 2075162 Most interestingly , *induced* the expression of [CTGF] and ICAM-1 , while silencing of HDAC-7 had no effect on their expression . Positive_regulation CTGF PRKACB 16813525 1580698 [CCN2] was critically involved in osteolytic metastasis and was *induced* by and PKC dependent activation of ERK1/2 signaling by PTHrP . Positive_regulation CTGF PRKACG 16813525 1580699 [CCN2] was critically involved in osteolytic metastasis and was *induced* by and PKC dependent activation of ERK1/2 signaling by PTHrP . Positive_regulation CTGF PRKAR1A 16813525 1580700 [CCN2] was critically involved in osteolytic metastasis and was *induced* by and PKC dependent activation of ERK1/2 signaling by PTHrP . Positive_regulation CTGF PRKAR1B 16813525 1580701 [CCN2] was critically involved in osteolytic metastasis and was *induced* by and PKC dependent activation of ERK1/2 signaling by PTHrP . Positive_regulation CTGF PRKAR2A 16813525 1580702 [CCN2] was critically involved in osteolytic metastasis and was *induced* by and PKC dependent activation of ERK1/2 signaling by PTHrP . Positive_regulation CTGF PRKAR2B 16813525 1580703 [CCN2] was critically involved in osteolytic metastasis and was *induced* by and PKC dependent activation of ERK1/2 signaling by PTHrP . Positive_regulation CTGF PROK1 21098624 2372042 [CTGF] expression is *up-regulated* by in early pregnancy and influences HTR-8/Svneo cell adhesion and network formation . Positive_regulation CTGF PROK1 21098624 2372044 Inhibitors of specific cell signalling molecules demonstrated that *regulates* [CTGF] expression via the Gq , phospholipase C (PLC) , cSrc , epidermal growth factor receptor (EGFR) , mitogen activated protein kinase/extracellular signal regulated kinase ( MAPK/ERK ) kinase pathway activation . Positive_regulation CTGF PROK1 21098624 2372046 [CTGF] expression in early pregnancy decidua is *regulated* by , via activation of the Gq , PLC , cSrc , EGFR , MAPK/ERK kinase pathway . Positive_regulation CTGF PRR11 21265872 2403093 We hypothesized that in the presence of hyperglycaemia , increased renal expression *contributes* to enhanced [TGF-ß1-CTGF] signalling activity , leading to the development of diabetic kidney disease . Positive_regulation CTGF PRR12 21265872 2403099 We hypothesized that in the presence of hyperglycaemia , increased renal expression *contributes* to enhanced [TGF-ß1-CTGF] signalling activity , leading to the development of diabetic kidney disease . Positive_regulation CTGF PRR13 21265872 2403092 We hypothesized that in the presence of hyperglycaemia , increased renal expression *contributes* to enhanced [TGF-ß1-CTGF] signalling activity , leading to the development of diabetic kidney disease . Positive_regulation CTGF PRR14 21265872 2403097 We hypothesized that in the presence of hyperglycaemia , increased renal expression *contributes* to enhanced [TGF-ß1-CTGF] signalling activity , leading to the development of diabetic kidney disease . Positive_regulation CTGF PRR15 21265872 2403091 We hypothesized that in the presence of hyperglycaemia , increased renal expression *contributes* to enhanced [TGF-ß1-CTGF] signalling activity , leading to the development of diabetic kidney disease . Positive_regulation CTGF PRR16 21265872 2403100 We hypothesized that in the presence of hyperglycaemia , increased renal expression *contributes* to enhanced [TGF-ß1-CTGF] signalling activity , leading to the development of diabetic kidney disease . Positive_regulation CTGF PRR18 21265872 2403098 We hypothesized that in the presence of hyperglycaemia , increased renal expression *contributes* to enhanced [TGF-ß1-CTGF] signalling activity , leading to the development of diabetic kidney disease . Positive_regulation CTGF PRR19 21265872 2403104 We hypothesized that in the presence of hyperglycaemia , increased renal expression *contributes* to enhanced [TGF-ß1-CTGF] signalling activity , leading to the development of diabetic kidney disease . Positive_regulation CTGF PRR21 21265872 2403105 We hypothesized that in the presence of hyperglycaemia , increased renal expression *contributes* to enhanced [TGF-ß1-CTGF] signalling activity , leading to the development of diabetic kidney disease . Positive_regulation CTGF PRR22 21265872 2403096 We hypothesized that in the presence of hyperglycaemia , increased renal expression *contributes* to enhanced [TGF-ß1-CTGF] signalling activity , leading to the development of diabetic kidney disease . Positive_regulation CTGF PRR24 21265872 2403094 We hypothesized that in the presence of hyperglycaemia , increased renal expression *contributes* to enhanced [TGF-ß1-CTGF] signalling activity , leading to the development of diabetic kidney disease . Positive_regulation CTGF PRR25 21265872 2403106 We hypothesized that in the presence of hyperglycaemia , increased renal expression *contributes* to enhanced [TGF-ß1-CTGF] signalling activity , leading to the development of diabetic kidney disease . Positive_regulation CTGF PRR26 21265872 2403101 We hypothesized that in the presence of hyperglycaemia , increased renal expression *contributes* to enhanced [TGF-ß1-CTGF] signalling activity , leading to the development of diabetic kidney disease . Positive_regulation CTGF PRR3 21265872 2403090 We hypothesized that in the presence of hyperglycaemia , increased renal expression *contributes* to enhanced [TGF-ß1-CTGF] signalling activity , leading to the development of diabetic kidney disease . Positive_regulation CTGF PRR4 21265872 2403089 We hypothesized that in the presence of hyperglycaemia , increased renal expression *contributes* to enhanced [TGF-ß1-CTGF] signalling activity , leading to the development of diabetic kidney disease . Positive_regulation CTGF PRR5 21265872 2403102 We hypothesized that in the presence of hyperglycaemia , increased renal expression *contributes* to enhanced [TGF-ß1-CTGF] signalling activity , leading to the development of diabetic kidney disease . Positive_regulation CTGF PRR7 21265872 2403095 We hypothesized that in the presence of hyperglycaemia , increased renal expression *contributes* to enhanced [TGF-ß1-CTGF] signalling activity , leading to the development of diabetic kidney disease . Positive_regulation CTGF PRR9 21265872 2403103 We hypothesized that in the presence of hyperglycaemia , increased renal expression *contributes* to enhanced [TGF-ß1-CTGF] signalling activity , leading to the development of diabetic kidney disease . Positive_regulation CTGF PTGER2 12724323 1106574 Activation of prostaglandin receptors ( Gs-coupled ) also *up-regulated* Cyr61 but not [CTGF] mRNA expression in the isolated cat iris . Positive_regulation CTGF PTGS2 22415218 2740066 therefore , the [CTGF/CCN2] levels are maintained in the OSF tissues in the *presence* of . Positive_regulation CTGF PTH 20810452 2388947 Quantitative real-time RT-PCR analysis revealed that at a concentration of 10 ( -12 ) -10 ( -10 ) M *increased* the mRNA levels of [CTGF] , which was similar to the trends of CTGF protein levels detected by immunoblotting assay . Positive_regulation CTGF PTH 20810452 2388952 Moreover , both PD98059 and PDTC inhibited the effect of PTH on the expression of CTGF , which strongly suggests that these pathways play important roles in the *induced* [CTGF] upregulation in renal tubular cells . Positive_regulation CTGF PTH 20810452 2388954 Our results indicated for the first time that may *enhance* the expression of [CTGF] in human kidney proximal tubular cells , suggesting that PTH may play an important role in the fibrotic and inflammatory process that is a hallmark for progression of chronic kidney disease . Positive_regulation CTGF PTH 22166649 2366666 PD98059 inhibited the PTH stimulated expression of CTGF , which strongly suggested that the MAPK signaling pathway plays an important role in the *induced* [CTGF] upregulation in renal tubular cells . Positive_regulation CTGF PTHLH 16813525 1580682 Furthermore , we found that [CCN2] was *induced* by through PKA- , PKC- , and ERK mediated pathways therein . Positive_regulation CTGF PTHLH 16813525 1580704 [CCN2] was critically involved in osteolytic metastasis and was *induced* by PKA- and PKC dependent activation of ERK1/2 signaling by . Positive_regulation CTGF RAC1 18760941 2034448 signaling *regulates* [CTGF/CCN2] gene expression via TGFbeta/Smad signaling in chondrocytes . Positive_regulation CTGF RAC1 20117462 2202364 *induced* [connective tissue growth factor] regulates connexin 43 and N-cadherin expression in atrial fibrillation . Positive_regulation CTGF RAC1 20117462 2202369 In neonatal rat cardiomyocytes and fibroblasts , a specific small molecule inhibitor of or simvastatin completely *prevented* the angiotensin II-induced up-regulation of [CTGF] , Cx43 , and N-cadherin expression . Positive_regulation CTGF RAC1 22760500 2623147 Activation of by angiotensin II *leads* to a [CTGF-] and lysyl oxidase mediated increase of miR-21 expression contributing to structural remodelling of the atrial myocardium . Positive_regulation CTGF RAD1 21382976 2438186 Overexpression of in cultured neonatal cardiomyocytes *suppressed* both basal and transforming growth factor-ß1 induced [CTGF] expression . Positive_regulation CTGF RAD17 21382976 2438187 Overexpression of in cultured neonatal cardiomyocytes *suppressed* both basal and transforming growth factor-ß1 induced [CTGF] expression . Positive_regulation CTGF RAD18 21382976 2438185 Overexpression of in cultured neonatal cardiomyocytes *suppressed* both basal and transforming growth factor-ß1 induced [CTGF] expression . Positive_regulation CTGF RAD21 21382976 2438188 Overexpression of in cultured neonatal cardiomyocytes *suppressed* both basal and transforming growth factor-ß1 induced [CTGF] expression . Positive_regulation CTGF RAD50 21382976 2438189 Overexpression of in cultured neonatal cardiomyocytes *suppressed* both basal and transforming growth factor-ß1 induced [CTGF] expression . Positive_regulation CTGF RAD51 21382976 2438190 Overexpression of in cultured neonatal cardiomyocytes *suppressed* both basal and transforming growth factor-ß1 induced [CTGF] expression . Positive_regulation CTGF RAD52 21382976 2438191 Overexpression of in cultured neonatal cardiomyocytes *suppressed* both basal and transforming growth factor-ß1 induced [CTGF] expression . Positive_regulation CTGF RELA 16303051 1490773 *Activation* of by connective tissue growth factor ( [CCN2] ) is involved in sustaining the survival of primary rat hepatic stellate cells . Positive_regulation CTGF RELA 16707502 1584471 Thus , mechanical stretch induced changes in actin dynamics mediate activation and *induce* [CCN2] gene expression , which probably initiates the fibrotic reactions observed in mechanical overload associated pathologies . Positive_regulation CTGF RELA 20409024 2274282 A pharmacological inhibitor of , MG132 , *inhibited* LPS induced [CTGF] mRNA expression . Positive_regulation CTGF RENBP 11316739 806529 The aim of this study was to determine whether [CTGF] is *up-regulated* by in vitro and to explore the cellular mechanisms involved . Positive_regulation CTGF RENBP 11316739 806530 also *increased* [CTGF] protein in the conditioned medium and cell associated CTGF . Positive_regulation CTGF RENBP 11897682 921496 In summary , the induction of FN by AGE is partly mediated by the *induced* up-regulation of cell derived [CTGF] and is dependent on PKC activity . Positive_regulation CTGF RENBP 15579446 1344867 These results suggest that *induced* [CTGF] expression , predominantly through a TGF-beta 1-independent pathway , plays a critical role in renal ECM accumulation leading to diabetic nephropathy . Positive_regulation CTGF RENBP 15770649 1389917 Moreover , losartan ( a type I angiotensin receptor blocker ) and captopril ( an angiotensin converting enzyme inhibitor ) attenuated *induced* [CTGF] mRNA/protein expression while attenuating AGE induced mitogenesis and type I collagen production . Positive_regulation CTGF RENBP 18805993 2021184 and GDPs in PDS differentially *regulate* the synthesis of [CCN2] by peritoneal resident cells . Positive_regulation CTGF RENBP 19959709 2204077 Furthermore , conditional knockout of the gene encoding TGF-beta receptor II from the kidney did not prevent *induced* renal expression of [CTGF] and collagen I . Positive_regulation CTGF RENBP 19959709 2204078 Overexpressing Smad7 abolished *induced* Smad3 phosphorylation and [CTGF] expression , demonstrating the necessity for activation of Smad signaling in this process . Positive_regulation CTGF RETN 22040885 2503589 SFE at 1-25 µg/ml dose-dependently diminished *stimulated* secretion of collagen IV and [connective tissue growth factor (CTGF)] in HAoSMC , indicating that macrophage resistin plays a role in the extracellular matrix (ECM) production of vascular SMC . Positive_regulation CTGF RHO 17192487 1680334 Finally , fasudil , a kinase inhibitor already in clinical use , *inhibited* both Smad4 translocation and [CTGF] gene expression . Positive_regulation CTGF RHO 18829614 2034590 In addition , inhibition of the , which modulates the actin cytoskeleton , *impaired* [CTGF] expression . Positive_regulation CTGF RHO 19208742 2039195 Up-regulation of [CTGF] by CA-4P was *dependent* on kinase signaling and was increased when p42/44 mitogen activated protein kinase was inhibited . Positive_regulation CTGF RHO 19249354 2051014 signaling initiated by tubulin network collapse was *required* for both [CTGF] and PAI-1 induction . Positive_regulation CTGF RHO 20018872 2204700 Activation of kinase signaling by the microtubule disrupting drug combretastatin A4 also *enhanced* the DMOG induced [CTGF] expression , thus placing CTGF induction by hypoxia in a network of interacting signaling pathways . Positive_regulation CTGF RHO 24508728 2928465 Alveolar epithelial cell expression of [CTGF] was dramatically *reduced* by inhibition of signaling . Positive_regulation CTGF RHOA 11518778 851721 Interference with signaling similarly *inhibited* the induction of [CTGF] by TGF-beta . Positive_regulation CTGF RHOA 12947014 1151611 Specific interference with signaling by Y27632 primarily *reduced* basal [CTGF] expression . Positive_regulation CTGF RHOA 12951326 1158060 Interference with signaling by simvastatin , toxinB , C3 toxin , and Y27632 *prevented* up-regulation of [CTGF] . Positive_regulation CTGF RHOA 15560785 1341061 In particular , *dependent* regulation of the [CTGF/CCN2] gene was concomitant to increased polymerization of actin microfilaments resulting in decreased G- to F-actin ratio and appeared to be achieved at the transcriptional level . Positive_regulation CTGF RHOA 15970428 1497756 Differential involvement of the integrin linked kinase (ILK) in dependent rearrangement of F-actin fibers and *induction* of [connective tissue growth factor (CTGF)] . Positive_regulation CTGF RHOA 15970428 1497763 Inhibition of the RhoA associated kinase or overexpression of dominant negative RhoA reduced the stimulated CTGF expression indicative of a *role* for signaling in [CTGF] expression . Positive_regulation CTGF RHOA 16776827 1585544 We have previously shown that both [CTGF] overexpression and myofibroblast formation in IPF cell lines are *dependent* on signaling . Positive_regulation CTGF RHOA 17452038 1848291 Pharmacological inhibition of signaling *prevents* [connective tissue growth factor] induction in endothelial cells exposed to non-uniform shear stress . Positive_regulation CTGF RHOA 18287089 1891393 TGFbeta1 does not stimulate RhoA activation in gingival fibroblasts , and the overexpression of dominant negative does not *reduce* [CCN2/CTGF] expression in response to TGFbeta1 . Positive_regulation CTGF RHOA 20018872 2204701 Activation of kinase signaling by the microtubule disrupting drug combretastatin A4 also *enhanced* the DMOG induced [CTGF] expression , thus placing CTGF induction by hypoxia in a network of interacting signaling pathways . Positive_regulation CTGF RHOA 22761259 2634505 Expression of a constitutively active form of ( RhoAV14 ) , activation of Rho GTPase by bacterial toxin , or inhibition of Rho kinase by Y-27632 in HTM cells *led* to significant but contrasting changes in [CTGF] protein levels that were detectable in cell lysates and cell culture medium . Positive_regulation CTGF RHOA 23946291 2866237 Upregulation of the profibrotic cytokine [connective tissue growth factor (CTGF)] by mechanical strain is *dependent* on activation and inhibited by microtubule disruption . Positive_regulation CTGF ROCK1 18633694 1960042 MAPKs and inhibitors *blocked* [CTGF] overexpression induced by AngII . Positive_regulation CTGF ROCK1 19249354 2051015 signaling initiated by tubulin network collapse was *required* for both [CTGF] and PAI-1 induction . Positive_regulation CTGF ROCK2 18633694 1960043 MAPKs and inhibitors *blocked* [CTGF] overexpression induced by AngII . Positive_regulation CTGF ROCK2 19249354 2051016 signaling initiated by tubulin network collapse was *required* for both [CTGF] and PAI-1 induction . Positive_regulation CTGF RUNX2 21986102 2539631 complex negatively *regulates* TGF-ß induced [connective tissue growth factor] gene expression in vascular smooth muscle cells . Positive_regulation CTGF RUNX2 21986102 2539636 Forced expression of decreased and the reduction of Runx2 expression by small interfering RNA *enhanced* both basal and TGF-ß stimulated [CTGF] gene expression in HASMCs . Positive_regulation CTGF RUNX2 21986102 2539637 These results for the first time demonstrate that complex negatively *regulates* endogenous and TGF-ß induced [CTGF] gene expression in VSMCs . Positive_regulation CTGF S1PR2 18922980 1977410 *Induction* of antiproliferative [connective tissue growth factor] expression in Wilms' tumor cells by . Positive_regulation CTGF SERPINA3 20299474 2281616 The purpose of this study was to investigate the *role* of in the regulation of [CTGF] and fibrogenesis and its mechanism of action . Positive_regulation CTGF SERPINA3 20299474 2281650 Further , also *attenuated* the Wnt3a induced activation of the canonical Wnt pathway and the overexpression of [CTGF] . Positive_regulation CTGF SERPINE1 23872073 2835312 Genetic deficiency of either EGFR or p53 or functional blockade with AG1478 or Pifithrin-a , respectively , effectively inhibited [CTGF] *induction* and morphological transformation of renal fibroblasts as did SMAD3 knockdown or pretreatment with the SMAD3 inhibitor SIS3 . Positive_regulation CTGF SERPINE1 7564119 328371 Activation of gene expression without a change in u-PA favors accumulation of ECM proteins , as does *increased* expression of PDGF and [CTGF] which can also stimulate fibroblast proliferation in a paracrine manner . Positive_regulation CTGF SERPINE1 7593235 334630 NAK-1 , , and HSP-70 were induced or stimulated only in cells at the wound edge , u-PA was stimulated in cells away from the wound , and [CTGF] was *induced* in each of these populations suggesting that cell-to-cell communication may regulate gene expression after wounding . Positive_regulation CTGF SERPINF2 20008146 2191214 Moreover , we found that [connective tissue growth factor] *induced* the expression of through both the extracellular signal regulated kinase 1/2 ( ERK1/2 ) and c-Jun N-terminal kinase (JNK) pathways in fibroblasts . Positive_regulation CTGF SETD2 15315937 1322585 Hypoxic induction of [Ctgf] is directly *mediated* by . Positive_regulation CTGF SETD2 15315937 1322586 Furthermore , the observed *mediated* hypoxic stimulation of [Ctgf] expression was found to occur independently of TGF-beta(1) signaling . Positive_regulation CTGF SFTPC 15946238 1420872 Northern blot analysis showed that markedly *induced* [CTGF] mRNA expression in a dose- and time dependent manner . Positive_regulation CTGF SFTPC 15946238 1420874 Consistent with this result , Western blot analysis also showed that significantly *induced* the [CTGF] production . Positive_regulation CTGF SFTPC 15946238 1420875 Pretreatment with cycloheximide did not prevent the [CTGF] *induction* by , indicating that SPC stimulates CTGF mRNA expression without the increased synthesis of a regulatory protein . Positive_regulation CTGF SFTPC 15946238 1420876 Inhibition by pretreatment with Y27632 , but not by PD98059 ( a mitogen activated protein kinase 1/2 inhibitor ) and LY294002 ( a phosphatidylinositol 3-kinase inhibitor ) , indicated that rho-kinase pathway was involved in *induced* [CTGF] expression . Positive_regulation CTGF SGK1 16604333 1550799 *dependent* cardiac [CTGF] formation and fibrosis following DOCA treatment . Positive_regulation CTGF SGK1 18319604 1897564 *dependent* upregulation of [connective tissue growth factor] by angiotensin II . Positive_regulation CTGF SLC22A3 23073116 2716926 We demonstrated that [CTGF] *induced* of mesothelial cells in a dose- and time dependent manner . Positive_regulation CTGF SLC22A3 24703458 2938776 The constructed HK-C2AR cells could stably express RFP and CTGF proportionally , and the [CTGF] expressed in the cell line could *induce* of cells , whereas the RFP expressed in the cell could exhibit bright red fluorescence after excitation . Positive_regulation CTGF SLC4A3 24060896 2867087 We *induced* [CTGF] with or without the EP4 receptor blocker added to the bath in the presence of the epoxyeicosatrienoic acid synthesis inhibitor MS-PPOH . Positive_regulation CTGF SLPI 23722620 2853922 Our results revealed that [CTGF] *induced* the expression of several bone markers , including , osteocalcin (OC) , osteoprotegerin (OPG) and core binding factor subunit a1 ( Cbfa1 ) /runt related transcription factor 2 ( Runx2 ) , as well as calcification . Positive_regulation CTGF SMAD1 12368229 1019220 The mediated *induction* of [connective tissue growth factor (CTGF)] , a fibroproliferative cytokine , by transforming growth factor (TGF)beta is required for the development of sustained fibrosis in humans . Positive_regulation CTGF SMAD1 12368229 1019229 Here , we show that in fibroblasts , activation of the Ras/MEK/ERK pathway is required for the mediated *induction* of [CTGF] by TGFbeta2 . Positive_regulation CTGF SMAD1 15855807 1425591 TGF-beta1 induced connective tissue growth factor ( [CCN2] ) expression in human renal proximal tubule epithelial cells *requires* Ras/MEK/ERK and signalling . Positive_regulation CTGF SMAD1 15855807 1425638 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Positive_regulation CTGF SMAD1 19249354 2050983 Differential *requirement* for MEK/ERK and signaling in PAI-1 and [CTGF] expression in response to microtubule disruption . Positive_regulation CTGF SMAD1 20382513 2287749 Furthermore , the augmented expression of [CTGF] and TIMP-2 in HG-exposed cells was *mediated* by Akt activation and signaling through PKCbeta2-responsive signaling pathways . Positive_regulation CTGF SMAD1 21541658 2531853 Furthermore , activated signaling by podocytes may *induce* [connective tissue growth factor] and vascular endothelial growth factor overexpression , which could act as a paracrine effector mechanism on mesangial cells to stimulate mesangial matrix synthesis . Positive_regulation CTGF SMAD1 22350758 2586830 In the *presence* of inhibitors of PI3K , Src , , or reactive oxygen species , the effect of NRG1 on [CTGF] expression decreased significantly . Positive_regulation CTGF SMAD1 22806900 2628855 Activated signaling by podocytes may *induce* [connective tissue growth factor] ( CTGF or CCN2 ) and vascular endothelial growth factor ( VEGF ) expression . Positive_regulation CTGF SMAD1 22938209 2697665 Only part of these cells also synthesized CTGF indicating that activation alone was not *sufficient* for [CTGF] induction . Positive_regulation CTGF SMAD2 12368229 1019221 The mediated *induction* of [connective tissue growth factor (CTGF)] , a fibroproliferative cytokine , by transforming growth factor (TGF)beta is required for the development of sustained fibrosis in humans . Positive_regulation CTGF SMAD2 12368229 1019230 Here , we show that in fibroblasts , activation of the Ras/MEK/ERK pathway is required for the *mediated* induction of [CTGF] by TGFbeta2 . Positive_regulation CTGF SMAD2 15144593 1247596 suppression of phosphorylation of with Staurosporine , a Serine/Threonine kinase inhibitor , *diminished* TGF beta(1) triggered expression of [CTGF] protein , while blockade of phosphorylation of ERK ( 1/2 ) with PD98059 , a specific ERK ( 1/2 ) activation inhibitor , did not decrease the TGF beta(1) triggered expression of CTGF protein . Positive_regulation CTGF SMAD2 15855807 1425592 TGF-beta1 induced [connective tissue growth factor] ( CCN2 ) expression in human renal proximal tubule epithelial cells *requires* Ras/MEK/ERK and signalling . Positive_regulation CTGF SMAD2 15855807 1425639 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Positive_regulation CTGF SMAD2 17317656 1719553 We demonstrate that the TGF-betaRI dependent up-regulation of collagen and [CCN2] ( CTGF ) does not *involve* activation but is mediated by ALK1/Smad1 and ERK1/2 pathways . Positive_regulation CTGF SMAD2 19249354 2050984 Differential *requirement* for MEK/ERK and signaling in PAI-1 and [CTGF] expression in response to microtubule disruption . Positive_regulation CTGF SMAD2 19309720 2087064 In this analysis , we found ( 1 ) a selective transcriptional *activation* of the [CTGF] promoter by ( but not Smad3 ) ; Positive_regulation CTGF SMAD2 19429239 2077256 The results suggest that 15d-PGJ ( 2 ) *inhibits* TGF-beta induced [CTGF] expression by inhibiting the phosphorylation of , which is independent of PPAR , and 15d-PGJ ( 2 ) might also act through a PPAR dependent mechanism in human hepatoma cells . Positive_regulation CTGF SMAD2 19667256 2138703 We found that Ang II-induced tubular [CTGF] and collagen I mRNA and protein expressions were *regulated* positively by phosphorylated but negatively by Smad7 because overexpression of Smad7 abolished Ang II-induced Smad2/3 phosphorylation and upregulation of CTGF and collagen I in vitro and in a rat model of remnant kidney disease . Positive_regulation CTGF SMAD2 19959709 2204080 More important , knockdown of either Smad3 or Smad2 demonstrated that Smad3 but not is *essential* for [CTGF] induction in response to AGEs . Positive_regulation CTGF SMAD2 20382513 2287750 Furthermore , the augmented expression of [CTGF] and TIMP-2 in HG-exposed cells was *mediated* by Akt activation and signaling through PKCbeta2-responsive signaling pathways . Positive_regulation CTGF SMAD2 21541658 2531854 Furthermore , activated signaling by podocytes may *induce* [connective tissue growth factor] and vascular endothelial growth factor overexpression , which could act as a paracrine effector mechanism on mesangial cells to stimulate mesangial matrix synthesis . Positive_regulation CTGF SMAD2 22350758 2586831 In the *presence* of inhibitors of PI3K , Src , , or reactive oxygen species , the effect of NRG1 on [CTGF] expression decreased significantly . Positive_regulation CTGF SMAD2 22576977 2681458 *dependent* [CCN2] transactivation was measured by luciferase reporter assay . Positive_regulation CTGF SMAD2 22806900 2628856 Activated signaling by podocytes may *induce* [connective tissue growth factor] ( CTGF or CCN2 ) and vascular endothelial growth factor ( VEGF ) expression . Positive_regulation CTGF SMAD2 22938209 2697666 Only part of these cells also synthesized CTGF indicating that activation alone was not *sufficient* for [CTGF] induction . Positive_regulation CTGF SMAD2 23287510 2745972 In summary , we provide strong evidence that AngII exposure first resulted in *dependent* production of [CTGF] by resident cells ( 6 hours ) , well before the accumulation of fibrocytes or TGF-ß mRNA up-regulation . Positive_regulation CTGF SMAD3 11590167 882907 Peroxisome proliferator activated receptor gamma *inhibits* transforming growth factor beta induced [connective tissue growth factor] expression in human aortic smooth muscle cells by interfering with . Positive_regulation CTGF SMAD3 12368229 1019222 The mediated *induction* of [connective tissue growth factor (CTGF)] , a fibroproliferative cytokine , by transforming growth factor (TGF)beta is required for the development of sustained fibrosis in humans . Positive_regulation CTGF SMAD3 12368229 1019231 Here , we show that in fibroblasts , activation of the Ras/MEK/ERK pathway is required for the mediated *induction* of [CTGF] by TGFbeta2 . Positive_regulation CTGF SMAD3 15855807 1425593 TGF-beta1 induced connective tissue growth factor ( [CCN2] ) expression in human renal proximal tubule epithelial cells *requires* Ras/MEK/ERK and signalling . Positive_regulation CTGF SMAD3 15855807 1425640 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Positive_regulation CTGF SMAD3 15955090 1421998 Adenoviral overexpression of enhanced the TGF-beta elicited expression of CTGF , whereas Smad7 and dominant negative Smad3 *suppressed* the effects of TGF-beta on [CTGF] and Cyr61 expression . Positive_regulation CTGF SMAD3 15987746 1446777 Activation of was *essential* for TGF-beta1 induced [CTGF] transcription , but PTX did not interfere with TGF-beta1 signaling to Smad2/3 activation and association with Smad4 and their nuclear translocation . Positive_regulation CTGF SMAD3 15987746 1446779 The protein kinase A antagonist H89 abolished the inhibitory effect of PTX on *dependent* [CTGF] transcription , whereas dibutyryl cAMP and forskolin recapitulated the inhibitory effect . Positive_regulation CTGF SMAD3 15987746 1446785 In conclusion , these results indicate that PTX inhibits CTGF expression by interfering with *dependent* [CTGF] transcription through protein kinase A and blocks the profibrogenic effects of CTGF on renal cells . Positive_regulation CTGF SMAD3 17317656 1719554 We demonstrate that the TGF-betaRI dependent up-regulation of collagen and [CCN2] ( CTGF ) does not *involve* activation but is mediated by ALK1/Smad1 and ERK1/2 pathways . Positive_regulation CTGF SMAD3 19249354 2050985 Differential *requirement* for MEK/ERK and signaling in PAI-1 and [CTGF] expression in response to microtubule disruption . Positive_regulation CTGF SMAD3 19249354 2051020 Colchicine initiated phosphorylation , however , was *essential* for PAI-1 , but not [CTGF] , expression further highlighting divergence of signaling events downstream of Rho/ROCK that mediate microtubule deformation associated changes in profibrotic gene transcription . Positive_regulation CTGF SMAD3 19570811 2142558 This arterial cell-cell communication is likely to be mediated by *dependent* production of [CTGF] . Positive_regulation CTGF SMAD3 19667256 2138704 We found that Ang II-induced tubular [CTGF] and collagen I mRNA and protein expressions were *regulated* positively by phosphorylated but negatively by Smad7 because overexpression of Smad7 abolished Ang II-induced Smad2/3 phosphorylation and upregulation of CTGF and collagen I in vitro and in a rat model of remnant kidney disease . Positive_regulation CTGF SMAD3 19959709 2204081 More important , knockdown of either Smad3 or Smad2 demonstrated that but not Smad2 is *essential* for [CTGF] induction in response to AGEs . Positive_regulation CTGF SMAD3 20213804 2249217 [CTGF] *induced* phosphorylation of p38 , ERK-1/2 , JNK , and Akt , but not , in transgenic mouse fibroblasts compared with wild-type mouse fibroblasts . Positive_regulation CTGF SMAD3 20222112 2281580 Analysis showed that full-length and the Smad3 MH-2 domain alone *increased* [CTGF] activity . Positive_regulation CTGF SMAD3 20382513 2287751 Furthermore , the augmented expression of [CTGF] and TIMP-2 in HG-exposed cells was *mediated* by Akt activation and signaling through PKCbeta2-responsive signaling pathways . Positive_regulation CTGF SMAD3 21541658 2531855 Furthermore , activated signaling by podocytes may *induce* [connective tissue growth factor] and vascular endothelial growth factor overexpression , which could act as a paracrine effector mechanism on mesangial cells to stimulate mesangial matrix synthesis . Positive_regulation CTGF SMAD3 21986102 2539632 complex negatively *regulates* TGF-ß induced [connective tissue growth factor] gene expression in vascular smooth muscle cells . Positive_regulation CTGF SMAD3 21986102 2539638 These results for the first time demonstrate that complex negatively *regulates* endogenous and TGF-ß induced [CTGF] gene expression in VSMCs . Positive_regulation CTGF SMAD3 22329991 2565707 Expression of [CTGF] in MM cells was *induced* by the formation of a complex on the CTGF promoter . Positive_regulation CTGF SMAD3 22350758 2586832 In the *presence* of inhibitors of PI3K , Src , , or reactive oxygen species , the effect of NRG1 on [CTGF] expression decreased significantly . Positive_regulation CTGF SMAD3 22576977 2681457 Mechanical stretch increases *dependent* [CCN2] expression in inner meniscus cells . Positive_regulation CTGF SMAD3 22576977 2681459 dependent [CCN2] *transactivation* was measured by luciferase reporter assay . Positive_regulation CTGF SMAD3 22576977 2681461 The [CCN2] promoter activity was synergistically *enhanced* by overexpressed in stretched inner meniscus cells , but was not by Smad2 . Positive_regulation CTGF SMAD3 22806900 2628857 Activated signaling by podocytes may *induce* [connective tissue growth factor] ( CTGF or CCN2 ) and vascular endothelial growth factor ( VEGF ) expression . Positive_regulation CTGF SMAD3 22938209 2697667 Only part of these cells also synthesized CTGF indicating that activation alone was not *sufficient* for [CTGF] induction . Positive_regulation CTGF SMAD3 23609161 2800191 Previous studies have shown that JNK and activation is *required* for TGFß induced [CCN2] expressions in human gingival fibroblasts ( HGFs ) . Positive_regulation CTGF SMAD3 23631855 2784462 The [CCN2] promoter activity was cooperatively *enhanced* by CTS and in luciferase reporter assay . Positive_regulation CTGF SMAD4 12368229 1019223 The mediated *induction* of [connective tissue growth factor (CTGF)] , a fibroproliferative cytokine , by transforming growth factor (TGF)beta is required for the development of sustained fibrosis in humans . Positive_regulation CTGF SMAD4 12368229 1019232 Here , we show that in fibroblasts , activation of the Ras/MEK/ERK pathway is required for the *mediated* induction of [CTGF] by TGFbeta2 . Positive_regulation CTGF SMAD4 15855807 1425594 TGF-beta1 induced [connective tissue growth factor] ( CCN2 ) expression in human renal proximal tubule epithelial cells *requires* Ras/MEK/ERK and signalling . Positive_regulation CTGF SMAD4 15855807 1425641 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Positive_regulation CTGF SMAD4 15987746 1446778 Activation of was *essential* for TGF-beta1 induced [CTGF] transcription , but PTX did not interfere with TGF-beta1 signaling to Smad2/3 activation and association with Smad4 and their nuclear translocation . Positive_regulation CTGF SMAD4 15987746 1446780 The protein kinase A antagonist H89 abolished the inhibitory effect of PTX on *dependent* [CTGF] transcription , whereas dibutyryl cAMP and forskolin recapitulated the inhibitory effect . Positive_regulation CTGF SMAD4 15987746 1446786 In conclusion , these results indicate that PTX inhibits CTGF expression by interfering with *dependent* [CTGF] transcription through protein kinase A and blocks the profibrogenic effects of CTGF on renal cells . Positive_regulation CTGF SMAD4 19249354 2050986 Differential *requirement* for MEK/ERK and signaling in PAI-1 and [CTGF] expression in response to microtubule disruption . Positive_regulation CTGF SMAD4 20382513 2287752 Furthermore , the augmented expression of [CTGF] and TIMP-2 in HG-exposed cells was *mediated* by Akt activation and signaling through PKCbeta2-responsive signaling pathways . Positive_regulation CTGF SMAD4 21541658 2531856 Furthermore , activated signaling by podocytes may *induce* [connective tissue growth factor] and vascular endothelial growth factor overexpression , which could act as a paracrine effector mechanism on mesangial cells to stimulate mesangial matrix synthesis . Positive_regulation CTGF SMAD4 22350758 2586833 In the *presence* of inhibitors of PI3K , Src , , or reactive oxygen species , the effect of NRG1 on [CTGF] expression decreased significantly . Positive_regulation CTGF SMAD4 22806900 2628858 Activated signaling by podocytes may *induce* [connective tissue growth factor] ( CTGF or CCN2 ) and vascular endothelial growth factor ( VEGF ) expression . Positive_regulation CTGF SMAD4 22938209 2697668 Only part of these cells also synthesized CTGF indicating that activation alone was not *sufficient* for [CTGF] induction . Positive_regulation CTGF SMAD4 23816882 2824709 In Tgfbr2 mutant embryos , downregulation of Ctgf expression is associated with p38 mitogen activated protein kinase (MAPK) overactivation , whereas loss of function of itself *leads* to downregulation of [Ctgf] expression . Positive_regulation CTGF SMAD5 12368229 1019224 The mediated *induction* of [connective tissue growth factor (CTGF)] , a fibroproliferative cytokine , by transforming growth factor (TGF)beta is required for the development of sustained fibrosis in humans . Positive_regulation CTGF SMAD5 12368229 1019233 Here , we show that in fibroblasts , activation of the Ras/MEK/ERK pathway is required for the mediated *induction* of [CTGF] by TGFbeta2 . Positive_regulation CTGF SMAD5 15855807 1425595 TGF-beta1 induced connective tissue growth factor ( [CCN2] ) expression in human renal proximal tubule epithelial cells *requires* Ras/MEK/ERK and signalling . Positive_regulation CTGF SMAD5 15855807 1425642 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Positive_regulation CTGF SMAD5 19249354 2050987 Differential *requirement* for MEK/ERK and signaling in PAI-1 and [CTGF] expression in response to microtubule disruption . Positive_regulation CTGF SMAD5 20382513 2287753 Furthermore , the augmented expression of [CTGF] and TIMP-2 in HG-exposed cells was *mediated* by Akt activation and signaling through PKCbeta2-responsive signaling pathways . Positive_regulation CTGF SMAD5 21541658 2531857 Furthermore , activated signaling by podocytes may *induce* [connective tissue growth factor] and vascular endothelial growth factor overexpression , which could act as a paracrine effector mechanism on mesangial cells to stimulate mesangial matrix synthesis . Positive_regulation CTGF SMAD5 22350758 2586834 In the *presence* of inhibitors of PI3K , Src , , or reactive oxygen species , the effect of NRG1 on [CTGF] expression decreased significantly . Positive_regulation CTGF SMAD5 22806900 2628859 Activated signaling by podocytes may *induce* [connective tissue growth factor] ( CTGF or CCN2 ) and vascular endothelial growth factor ( VEGF ) expression . Positive_regulation CTGF SMAD5 22938209 2697669 Only part of these cells also synthesized CTGF indicating that activation alone was not *sufficient* for [CTGF] induction . Positive_regulation CTGF SMAD6 12368229 1019225 The mediated *induction* of [connective tissue growth factor (CTGF)] , a fibroproliferative cytokine , by transforming growth factor (TGF)beta is required for the development of sustained fibrosis in humans . Positive_regulation CTGF SMAD6 12368229 1019234 Here , we show that in fibroblasts , activation of the Ras/MEK/ERK pathway is required for the *mediated* induction of [CTGF] by TGFbeta2 . Positive_regulation CTGF SMAD6 15855807 1425596 TGF-beta1 induced [connective tissue growth factor] ( CCN2 ) expression in human renal proximal tubule epithelial cells *requires* Ras/MEK/ERK and signalling . Positive_regulation CTGF SMAD6 15855807 1425643 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Positive_regulation CTGF SMAD6 19249354 2050988 Differential *requirement* for MEK/ERK and signaling in PAI-1 and [CTGF] expression in response to microtubule disruption . Positive_regulation CTGF SMAD6 20382513 2287754 Furthermore , the augmented expression of [CTGF] and TIMP-2 in HG-exposed cells was *mediated* by Akt activation and signaling through PKCbeta2-responsive signaling pathways . Positive_regulation CTGF SMAD6 21541658 2531858 Furthermore , activated signaling by podocytes may *induce* [connective tissue growth factor] and vascular endothelial growth factor overexpression , which could act as a paracrine effector mechanism on mesangial cells to stimulate mesangial matrix synthesis . Positive_regulation CTGF SMAD6 22350758 2586835 In the *presence* of inhibitors of PI3K , Src , , or reactive oxygen species , the effect of NRG1 on [CTGF] expression decreased significantly . Positive_regulation CTGF SMAD6 22806900 2628860 Activated signaling by podocytes may *induce* [connective tissue growth factor] ( CTGF or CCN2 ) and vascular endothelial growth factor ( VEGF ) expression . Positive_regulation CTGF SMAD6 22938209 2697670 Only part of these cells also synthesized CTGF indicating that activation alone was not *sufficient* for [CTGF] induction . Positive_regulation CTGF SMAD7 12368229 1019226 The mediated *induction* of [connective tissue growth factor (CTGF)] , a fibroproliferative cytokine , by transforming growth factor (TGF)beta is required for the development of sustained fibrosis in humans . Positive_regulation CTGF SMAD7 12368229 1019235 Here , we show that in fibroblasts , activation of the Ras/MEK/ERK pathway is required for the mediated *induction* of [CTGF] by TGFbeta2 . Positive_regulation CTGF SMAD7 15855807 1425597 TGF-beta1 induced connective tissue growth factor ( [CCN2] ) expression in human renal proximal tubule epithelial cells *requires* Ras/MEK/ERK and signalling . Positive_regulation CTGF SMAD7 15855807 1425644 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Positive_regulation CTGF SMAD7 19249354 2050989 Differential *requirement* for MEK/ERK and signaling in PAI-1 and [CTGF] expression in response to microtubule disruption . Positive_regulation CTGF SMAD7 19349682 2057599 Compared with the UUO group , the degree of renal interstitial lesion and the expression of TGF-beta1 mRNA , CTGF mRNA , alpha-SMA and [CTGF] were decreased , but the expression of *increased* in the treatment group . Positive_regulation CTGF SMAD7 19667256 2138705 We found that Ang II-induced tubular [CTGF] and collagen I mRNA and protein expressions were *regulated* positively by phosphorylated Smad2/3 but negatively by because overexpression of Smad7 abolished Ang II-induced Smad2/3 phosphorylation and upregulation of CTGF and collagen I in vitro and in a rat model of remnant kidney disease . Positive_regulation CTGF SMAD7 20382513 2287755 Furthermore , the augmented expression of [CTGF] and TIMP-2 in HG-exposed cells was *mediated* by Akt activation and signaling through PKCbeta2-responsive signaling pathways . Positive_regulation CTGF SMAD7 21541658 2531859 Furthermore , activated signaling by podocytes may *induce* [connective tissue growth factor] and vascular endothelial growth factor overexpression , which could act as a paracrine effector mechanism on mesangial cells to stimulate mesangial matrix synthesis . Positive_regulation CTGF SMAD7 22350758 2586836 In the *presence* of inhibitors of PI3K , Src , , or reactive oxygen species , the effect of NRG1 on [CTGF] expression decreased significantly . Positive_regulation CTGF SMAD7 22806900 2628861 Activated signaling by podocytes may *induce* [connective tissue growth factor] ( CTGF or CCN2 ) and vascular endothelial growth factor ( VEGF ) expression . Positive_regulation CTGF SMAD7 22938209 2697671 Only part of these cells also synthesized CTGF indicating that activation alone was not *sufficient* for [CTGF] induction . Positive_regulation CTGF SMAD7 24090133 2867555 Inhibition of expression in CCD-1068SK fibroblasts *resulted* in increased [CCN2] expression , while Smad7 overexpression had the opposite effect . Positive_regulation CTGF SMAD9 12368229 1019227 The mediated *induction* of [connective tissue growth factor (CTGF)] , a fibroproliferative cytokine , by transforming growth factor (TGF)beta is required for the development of sustained fibrosis in humans . Positive_regulation CTGF SMAD9 12368229 1019236 Here , we show that in fibroblasts , activation of the Ras/MEK/ERK pathway is required for the *mediated* induction of [CTGF] by TGFbeta2 . Positive_regulation CTGF SMAD9 15855807 1425598 TGF-beta1 induced [connective tissue growth factor] ( CCN2 ) expression in human renal proximal tubule epithelial cells *requires* Ras/MEK/ERK and signalling . Positive_regulation CTGF SMAD9 15855807 1425645 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Positive_regulation CTGF SMAD9 19249354 2050990 Differential *requirement* for MEK/ERK and signaling in PAI-1 and [CTGF] expression in response to microtubule disruption . Positive_regulation CTGF SMAD9 20382513 2287756 Furthermore , the augmented expression of [CTGF] and TIMP-2 in HG-exposed cells was *mediated* by Akt activation and signaling through PKCbeta2-responsive signaling pathways . Positive_regulation CTGF SMAD9 21541658 2531860 Furthermore , activated signaling by podocytes may *induce* [connective tissue growth factor] and vascular endothelial growth factor overexpression , which could act as a paracrine effector mechanism on mesangial cells to stimulate mesangial matrix synthesis . Positive_regulation CTGF SMAD9 22350758 2586837 In the *presence* of inhibitors of PI3K , Src , , or reactive oxygen species , the effect of NRG1 on [CTGF] expression decreased significantly . Positive_regulation CTGF SMAD9 22806900 2628862 Activated signaling by podocytes may *induce* [connective tissue growth factor] ( CTGF or CCN2 ) and vascular endothelial growth factor ( VEGF ) expression . Positive_regulation CTGF SMAD9 22938209 2697672 Only part of these cells also synthesized CTGF indicating that activation alone was not *sufficient* for [CTGF] induction . Positive_regulation CTGF SMN1 22542845 2602929 [CTGF] *induces* TM fibronectin and in animals , whereas actin stress fibers and contractility are both induced in cultured TM cells . Positive_regulation CTGF SMN1 23525012 2794302 Both adenoviral expression of [CTGF] in epithelial cells and treatment with recombinant CTGF *induced* EMT-like morphological changes and expression of . Positive_regulation CTGF SMN1 24486572 2923624 These results suggest that ET-1 stimulates expressions of CTGF and through ETAR/JNK/AP-1 signaling pathway , and [CTGF] is *required* for ET-1 induced a-SMA expression in human lung fibroblasts . Positive_regulation CTGF SP1 12234285 988804 The previously identified basal control element-1 ( BCE-1 ) site , but not *contributes* to basal [CTGF] promoter activity . Positive_regulation CTGF SRC 20432467 2282449 In this study we demonstrate that TGF-beta1 activates Src kinase in ROS17/2.8 cells and that treatment with the Src family kinase inhibitor PP2 prevents activation and [CTGF] *induction* by TGF-beta1 . Positive_regulation CTGF SRC 23108098 2721397 In this study , we further investigated the *roles* of , JAK2 , and STAT3 in thrombin induced [CCN2] expression . Positive_regulation CTGF SRL 16926534 1615024 On the other hand , *increased* [CTGF] expression by 3.5-fold . Positive_regulation CTGF STAT1 22814105 2640033 Silencing of or STAT3 *attenuated* basal [CTGF] mRNA levels indicating that both STAT isoforms may be involved in the regulation of basal CTGF mRNA expression . Positive_regulation CTGF STAT3 22814105 2640034 Silencing of STAT1 or *attenuated* basal [CTGF] mRNA levels indicating that both STAT isoforms may be involved in the regulation of basal CTGF mRNA expression . Positive_regulation CTGF STAT3 23108098 2721409 Taken together , these results indicate that thrombin might activate c-Src to induce JAK2 activation , which in turn , causes activation , and finally *induces* [CCN2] expression in human lung fibroblasts . Positive_regulation CTGF STAT3 24005672 2856221 Transforming growth factor-ß ( TGF-ß ) -mediated [connective tissue growth factor (CTGF)] expression in hepatic stellate cells *requires* signaling activation . Positive_regulation CTGF STAT6 21804025 2467678 Furthermore , IL-13 induces Stat6 phosphorylation in HSCs , but was not *involved* in [CTGF] induction . Positive_regulation CTGF TAC1 20534773 2315701 TMZ significantly inhibited collagen accumulation , [CTGF] expression , and reactive oxygen species ( ROS ) production *induced* by . Positive_regulation CTGF TAC3 20534773 2315702 TMZ significantly inhibited collagen accumulation , [CTGF] expression , and reactive oxygen species ( ROS ) production *induced* by . Positive_regulation CTGF TAC4 20534773 2315703 TMZ significantly inhibited collagen accumulation , [CTGF] expression , and reactive oxygen species ( ROS ) production *induced* by . Positive_regulation CTGF TAT 22461303 2624498 However , tempol , apocynin , and *had* no effect on [CTGF] in the absence of ANG II . Positive_regulation CTGF TAZ 19498055 2115856 In vitro studies showed that *up-regulated* [Ctgf] expression not only by reinforcing transforming growth factor-beta/smad signals , but also by interfering in the more proximal Ctgf promoter region ( from bp -123 to -76 ) , defined as the TAZ response element . Positive_regulation CTGF TCF12 18172013 1875572 Novel function of human matrix metalloproteinase 3 *regulating* the [CTGF/CCN2] gene . Positive_regulation CTGF TCF15 18172013 1875573 Novel function of human matrix metalloproteinase 3 *regulating* the [CTGF/CCN2] gene . Positive_regulation CTGF TCF19 18172013 1875574 Novel function of human matrix metalloproteinase 3 *regulating* the [CTGF/CCN2] gene . Positive_regulation CTGF TCF20 18172013 1875575 Novel function of human matrix metalloproteinase 3 *regulating* the [CTGF/CCN2] gene . Positive_regulation CTGF TCF21 17551956 1848379 Suppression of by siRNA *resulted* in increased cell proliferation and reduced expression of alphaSMA , fibronectin , and [CTGF] , and myofibroblast secreted proteins including pro-fibrotic cytokines and inhibitors of matrix metalloproteinases . Positive_regulation CTGF TCF21 18172013 1875576 Novel function of human matrix metalloproteinase 3 *regulating* the [CTGF/CCN2] gene . Positive_regulation CTGF TCF23 18172013 1875580 Novel function of human matrix metalloproteinase 3 *regulating* the [CTGF/CCN2] gene . Positive_regulation CTGF TCF24 18172013 1875582 Novel function of human matrix metalloproteinase 3 *regulating* the [CTGF/CCN2] gene . Positive_regulation CTGF TCF25 18172013 1875581 Novel function of human matrix metalloproteinase 3 *regulating* the [CTGF/CCN2] gene . Positive_regulation CTGF TCF3 18172013 1875577 Novel function of human matrix metalloproteinase 3 *regulating* the [CTGF/CCN2] gene . Positive_regulation CTGF TCF4 18172013 1875578 Novel function of human matrix metalloproteinase 3 *regulating* the [CTGF/CCN2] gene . Positive_regulation CTGF TCF7 18172013 1875579 Novel function of human matrix metalloproteinase 3 *regulating* the [CTGF/CCN2] gene . Positive_regulation CTGF TEAD1 24380865 2906725 The PDZ binding motif of Yes associated protein is required for its co-activation of *mediated* [CTGF] transcription and oncogenic cell transforming activity . Positive_regulation CTGF TEAD2 24380865 2906726 The PDZ binding motif of Yes associated protein is required for its co-activation of *mediated* [CTGF] transcription and oncogenic cell transforming activity . Positive_regulation CTGF TEAD3 24380865 2906727 The PDZ binding motif of Yes associated protein is required for its co-activation of *mediated* [CTGF] transcription and oncogenic cell transforming activity . Positive_regulation CTGF TEAD4 22329991 2565706 Expression of [CTGF] in MM cells was *induced* by the formation of a complex on the CTGF promoter . Positive_regulation CTGF TEAD4 24380865 2906728 The PDZ binding motif of Yes associated protein is required for its co-activation of *mediated* [CTGF] transcription and oncogenic cell transforming activity . Positive_regulation CTGF TGFB1 10098490 601633 Intact [CTGF] was *increased* by cAMP but not by ( TGFbeta ) . Positive_regulation CTGF TGFB1 10607888 575191 *induces* apoptosis via [connective tissue growth factor] in human aortic smooth muscle cells . Positive_regulation CTGF TGFB1 10809757 692603 Tumor necrosis factor alpha suppresses the *induction* of [connective tissue growth factor] by in normal and scleroderma fibroblasts . Positive_regulation CTGF TGFB1 10976101 751898 Induction of CTGF mRNA was transient with maximal expression after 1 to 2 h , whereas *induction* of [CTGF] by ( TGF-beta ) increased over time . Positive_regulation CTGF TGFB1 11032743 740290 [Connective tissue growth factor (CTGF)] is *up-regulated* by during wound healing . Positive_regulation CTGF TGFB1 11032743 740291 Higher expression after inflammatory/necrotic process in the GalN regeneration may *caused* the prolonged [CTGF] expression . Positive_regulation CTGF TGFB1 11152469 795347 In normal adult fibroblasts , ( TGFbeta ) *induces* the expression of [connective tissue growth factor (CTGF)] . Positive_regulation CTGF TGFB1 11518710 868660 [Connective tissue growth factor (CTGF)] expression is *regulated* by ( TGF-beta ) and strong up-regulation occurs during wound healing ; Positive_regulation CTGF TGFB1 11590167 882904 Peroxisome proliferator activated receptor gamma inhibits *induced* [connective tissue growth factor] expression in human aortic smooth muscle cells by interfering with Smad3 . Positive_regulation CTGF TGFB1 11673871 872917 In the present work , we show that produces a 5- to 6-fold *increase* in [CTGF] expression by cultured human lung fibroblasts that is due mainly to increased transcription . Positive_regulation CTGF TGFB1 11874477 918783 [Connective tissue growth factor] , which is *induced* by , has been reported to mediate the stimulatory actions of transforming growth factor beta on type I procollagen synthesis . Positive_regulation CTGF TGFB1 11874477 918786 rapidly *induced* [connective tissue growth factor] mRNA levels ( 5-fold within 4 h ) in skin fibroblasts , but not keratinocytes , and this induction was attenuated 80 % by ultraviolet irradiation . Positive_regulation CTGF TGFB1 12065687 954661 ( TGF-beta1 ) strongly *stimulated* [CTGF] mRNA expression , a direct mechanism observed in the absence of any intermediate protein synthesis . Positive_regulation CTGF TGFB1 12368229 1019217 The SMAD mediated *induction* of [connective tissue growth factor (CTGF)] , a fibroproliferative cytokine , by is required for the development of sustained fibrosis in humans . Positive_regulation CTGF TGFB1 12444210 1017431 It also reduced the angiotensin II-induced or *induced* expression of [connective tissue growth factor] gene in cultured fibroblasts and mesangial cells . Positive_regulation CTGF TGFB1 12475893 1037701 In the case of TGF-beta1 transgenic ( TG ) mice with 5/6 Nx , excess derived from the transgene *enhanced* [CTGF] expression significantly in the remnant kidney , accordingly accelerating renal fibrogenesis . Positive_regulation CTGF TGFB1 12760970 1091435 C-Jun-NH2-terminal kinase mediates expression of [connective tissue growth factor] *induced* by in human lung fibroblasts . Positive_regulation CTGF TGFB1 12760970 1091436 Inhibition of p38 MAP kinase or extracellular signal regulated kinase ( ERK ) activation did not affect *induced* [CTGF] expression . Positive_regulation CTGF TGFB1 12760970 1091437 On the other hand , specific inhibitors of phosphatidylinositol 3-kinase (PI3K) suppressed *induced* [CTGF] expression in a concentration dependent manner . Positive_regulation CTGF TGFB1 12760970 1091442 Finally , JNK1 and JNK2 antisense oligonucleotides attenuated cellular levels of JNK1 and JNK2 protein , respectively , and repressed *induced* [CTGF] expression . Positive_regulation CTGF TGFB1 12760970 1091443 These results suggest that *induced* [CTGF] mRNA expression is mediated through the JNK dependent pathway , whereas p38 MAP kinase and ERK pathways minimally contribute . Positive_regulation CTGF TGFB1 15066218 1231665 *induced* increase of [CTGF] promoter activity was concentration dependent , with a plateau at 5 microg/L by 2.67-fold vs control ( P < 0.05 ) . Positive_regulation CTGF TGFB1 15066218 1231667 Blockade of MAPK pathway with PD98059 ( 10 micromol/L ) , the MAP kinase kinase 1 inhibitor , and SB203580 ( 10 micromol/L ) , the p38 MAP kinase inhibitor , decreased basal and *induced* activation of [CTGF] promoter . Positive_regulation CTGF TGFB1 15066218 1231669 *stimulated* the transcriptional activity of [CTGF] gene promoter in NIH/3T3 fibroblasts in a dose- and time dependent manner . Positive_regulation CTGF TGFB1 15066218 1231670 MAPK pathway may play a role in the regulation of *induced* [CTGF] expression . Positive_regulation CTGF TGFB1 15123357 1242404 [CCN2] promoter activity was *enhanced* by or PDGF via a Smad7 dependent pathway . Positive_regulation CTGF TGFB1 15144593 1247594 In this study , we observed the effects of three potent profibrotic growth factors-TGF beta(1) , Platelet derived growth factor ( PDGF ) , and Angiotensin II ( AngII ) on the expression of CTGF protein by Western blot analysis in cultured mouse podocytes , which is one of the most important cell construction of glomerular filter barrier , and we also investigated the underlying ERK and Smads signaling pathway through which *regulates* [CTGF] expression . Positive_regulation CTGF TGFB1 15144593 1247597 *stimulated* the expression of [CTGF] protein via Smad(2) dependent and ERK ( 1/2 ) -independent signaling pathway in podocyte in vitro . Positive_regulation CTGF TGFB1 15298857 1322229 [Connective tissue growth factor] expression and *induction* by is abrogated by simvastatin via a Rho signaling mechanism . Positive_regulation CTGF TGFB1 15319534 1286451 These results demonstrate that endoglin expression negatively regulates basal and *induced* [CTGF] and collagen expression and synthesis . Positive_regulation CTGF TGFB1 15377500 1353924 *induced* a time- and concentration dependent expression of [CTGF] gene and protein as analyzed by real-time RT-PCR and Western blot . Positive_regulation CTGF TGFB1 15387957 1300210 could *stimulate* the expression of [CTGF] gene promoter at the high level in a short time . Positive_regulation CTGF TGFB1 15387957 1300211 could *enhance* the activities of [CTGF] promoter in PSCs . Positive_regulation CTGF TGFB1 15536170 1374853 ( 2 ng/ml ) *stimulated* [CTGF] mRNA expression within 30 min , which was sustained for up to 24 h , with a consequent increase in CTGF protein ( P < 0.05 ) , whereas CTGF had no effect on TGF-beta(1) mRNA or protein expression . Positive_regulation CTGF TGFB1 15574513 1355725 In the present study , co-cultures of tubular epithelial cells ( mProx24 ) and tubulointerstitial fibroblasts ( TFB ) that mimic the subepithelial mesenchyme in the kidney were used to study the profibrotic effects of *induced* [CTGF] . Positive_regulation CTGF TGFB1 15855807 1425587 *induced* connective tissue growth factor ( [CCN2] ) expression in human renal proximal tubule epithelial cells requires Ras/MEK/ERK and Smad signalling . Positive_regulation CTGF TGFB1 15855807 1425626 In this study , we investigated the *induction* of [CCN2] by and the possible mechanisms of this induction in human PTECs . Positive_regulation CTGF TGFB1 15855807 1425627 Induction of [CCN2] in *response* to was studied at the gene promoter level by reporter gene assay , mRNA by semi-quantitative RT-PCR and protein by immunoblotting . Positive_regulation CTGF TGFB1 15855807 1425637 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the role of Smad signalling in *induction* of [CCN2] by . Positive_regulation CTGF TGFB1 15855807 1425654 *induced* [CCN2] promoter activity , mRNA and protein in human PTECs . Positive_regulation CTGF TGFB1 15855807 1425655 *dependent* [CCN2] promoter activity was reduced by inhibiting Ras and MEK activation . Positive_regulation CTGF TGFB1 15855807 1425667 *induces* the expression of [CCN2] in human PTECs . Positive_regulation CTGF TGFB1 15862293 1400931 [Connective tissue growth factor (CTGF)] is *induced* by ( TGF-beta ) via Smad activation in mesangial cells . Positive_regulation CTGF TGFB1 15864749 1401473 Sm ( 200 and 400 microg/ml ) significantly inhibited *stimulated* alpha-SMA secretion and the mRNA expressions of alpha-SMA , [CTGF] , and TIMP-1 in HSC-T6 cells . Positive_regulation CTGF TGFB1 15980944 1424711 [Connective tissue growth factor] *mediates* the profibrotic effects of produced by tubular epithelial cells in response to high glucose . Positive_regulation CTGF TGFB1 15987746 1446771 Here , it was demonstrated that PTX inhibited not only *induced* [CTGF] expression but also CTGF induced collagen I ( alpha1 ) [ Col I ( alpha1 ) ] expression in normal rat kidney fibroblasts ( NRK-49F ) and alpha-smooth muscle actin expression in normal rat kidney proximal tubular epithelial cells ( NRK-52E ) . Positive_regulation CTGF TGFB1 15987746 1446776 Activation of Smad3/4 was essential for *induced* [CTGF] transcription , but PTX did not interfere with TGF-beta1 signaling to Smad2/3 activation and association with Smad4 and their nuclear translocation . Positive_regulation CTGF TGFB1 16029631 1436066 [CTGF] *induced* a proliferative response in myofibroblast initiated by TGF-beta(1) , whereas had no action on proliferation . Positive_regulation CTGF TGFB1 16046020 1447723 *Induction* of [CTGF] by in normal and radiation enteritis human smooth muscle cells : Smad/Rho balance and therapeutic perspectives . Positive_regulation CTGF TGFB1 16046020 1447725 The aim of the present work was to investigate the balance between Smad and Rho signalling pathways in the [CTGF] *induction* and modulation of radiation induced fibrogenic differentiation after addition of pravastatin , an inhibitor of Rho isoprenylation . Positive_regulation CTGF TGFB1 16046020 1447726 Our results suggest that *induced* [CTGF] transactivation mainly depends on the Smad pathway in N-SMC , whereas in RE-SMC , Smad and Rho pathways are involved . Positive_regulation CTGF TGFB1 16143139 1451499 [CCN2] promoter activity was *stimulated* by , platelet derived growth factor , alcohol , or acetaldehyde . Positive_regulation CTGF TGFB1 16198104 1468459 *enhances* [connective tissue growth factor] expression in L6 rat skeletal myotubes . Positive_regulation CTGF TGFB1 16235529 1470522 The addition of HGF inhibited the *induced* TEMT , the secretion of FN , and the [CTGF] expression of NRK52E cells , there was a significant correlation between the expression of CTGF and the expression of alpha-SMA . Positive_regulation CTGF TGFB1 16469114 1573953 The *induction* of [CCN2] by involves Ets-1 . Positive_regulation CTGF TGFB1 16469114 1573959 Our results are consistent with the notion that Smad3 and Ets-1 cooperate in the *induction* of the [CCN2] promoter by . Positive_regulation CTGF TGFB1 16484225 1548584 [CCN2] is *induced* by ( TGFbeta ) in fibroblasts and is overexpressed in connective tissue disease . Positive_regulation CTGF TGFB1 16528248 1536295 The effects of tranilast on *induced* [CTGF] mRNA expression and on phosphorylation of Smad2 were determined . Positive_regulation CTGF TGFB1 16528248 1536314 These results suggest that tranilast is a potential effective antifibrotic compound in the kidney , exerting its effects via inhibition of *induced* [CTGF] expression and downstream activation of the Smad2 pathway in both PTCs and CFs . Positive_regulation CTGF TGFB1 16611331 1545311 *induced* [connective tissue growth factor] and chronic allograft rejection . Positive_regulation CTGF TGFB1 16636587 1583074 Previous studies found that ( TGF-beta ) *induces* mesothelial production of [connective tissue growth factor (CTGF)] , which may be downstream mediators of TGF-beta . Positive_regulation CTGF TGFB1 16723090 1565398 Furthermore , PPAR gamma ligands significantly suppressed *induced* [CTGF] expression ( at both transcriptional and post-transcriptional levels ) in HSC , and the inhibitory effect was dramatically , if not completely , abolished by pretreatment with GW9662 , suggesting that the inhibition was indeed mediated by PPAR gamma . Positive_regulation CTGF TGFB1 16723090 1565399 The PPAR gamma ligand has a potent inhibitory effect on the growth of HSC and *induced* [CTGF] expression , which makes it a potential antifibrotic candidate for the treatment and prevention of hepatic fibrosis . Positive_regulation CTGF TGFB1 16723984 1575949 However , aldosterone treatment did not induce transforming growth factor (TGF)-beta1 overproduction , and inhibition of by neutralization of TGF-beta1 protein did not significantly *prevent* aldosterone induced [CTGF] production . Positive_regulation CTGF TGFB1 16731742 1565869 Moreover , *caused* a further increase in [CTGF] expression in these cells . Positive_regulation CTGF TGFB1 16936247 1673104 *induced* [CTGF] expression can be blocked by TNF-alpha . Positive_regulation CTGF TGFB1 17029045 1496974 *stimulated* the expression of [connective tissue growth factor (CTGF)] in fibroblasts of patients with RA more than in those of patients with osteoarthritis ( OA ) . Positive_regulation CTGF TGFB1 17133352 1677725 Using primary cultures , we demonstrated that is a potent *inducer* of [CTGF] expression in osteoblasts , and that this induction occurred at all stages of osteoblast differentiation from the proliferative through mineralization stages . Positive_regulation CTGF TGFB1 17133352 1677726 When CTGF-specific siRNA was used to prevent *induction* of [CTGF] expression , it also inhibited collagen and fibronectin production , thereby demonstrating the requirement of CTGF for their up-regulation . Positive_regulation CTGF TGFB1 17133596 1661432 SPARC , an upstream regulator of [connective tissue growth factor] in *response* to stimulation . Positive_regulation CTGF TGFB1 17197570 1717519 ALK-5 mediates endogenous and *induced* expression of [connective tissue growth factor] in embryonic lung . Positive_regulation CTGF TGFB1 17197570 1717520 Since connective tissue growth factor (CTGF) is a downstream mediator of TGF-beta1 effects on mesenchymal cells , we hypothesized that *induces* [CTGF] expression in mouse embryonic lung explants and that CTGF mediates TGF-beta1 inhibition of branching morphogenesis . Positive_regulation CTGF TGFB1 17197570 1717523 These results demonstrate for the first time that induces CTGF expression in mouse embryonic lung explants , that CTGF inhibits branching morphogenesis , and that both endogenous and TGF-beta1 induced [CTGF] expression are *mediated* by the TbetaRI/ALK-5 dependent Smad2 signaling pathway . Positive_regulation CTGF TGFB1 17355828 1708672 The expression of CTGF siRNA mediated by PRS retrovirus vector can effectively reduce the level of [CTGF] and VEGF *induced* by in cultured HPMCs . Positive_regulation CTGF TGFB1 17393107 1716267 The results showed that could *induce* tubular [CTGF] and PAI-1 mRNA expression . Positive_regulation CTGF TGFB1 17407709 1722116 induced morphological changes , and *increased* the expressions of [CTGF] and collagen type III of the HSCs ( P less than 0.05 ) . Positive_regulation CTGF TGFB1 17412405 1748705 Whereas *induced* maximal [CTGF] expression after 12 hours ( 347 % +/- 23 % ) , histamine induced maximal CTGF expression was lower and delayed ( maximum expression of 204 % +/- 11 % after 48 hours ) . Positive_regulation CTGF TGFB1 17412405 1748706 Histamine and *stimulated* the [CTGF] promoter and the TGF-beta-response element in the CTGF promoter . Positive_regulation CTGF TGFB1 17428796 1742313 Prostaglandin E ( 2 ) blocks transforming growth factor *induced* [CCN2/CTGF] expression in lung and kidney fibroblasts . Positive_regulation CTGF TGFB1 17428796 1742314 Data demonstrate that the *induced* expression of [CCN2/CTGF] in human lung and renal mesangial cells is inhibited by 10 nm PGE ( 2 ) , whereas human gingival fibroblasts are resistant . Positive_regulation CTGF TGFB1 17428796 1742315 Micromolar PGE ( 2 ) only slightly reduces the *stimulated* [CCN2/CTGF] levels in gingival cells . Positive_regulation CTGF TGFB1 17428796 1742318 In lung fibroblasts , inhibition of the *stimulated* [CCN2/CTGF] by PGE ( 2 ) , butaprost , or forskolin is due to p38 , ERK , and JNK MAP kinase inhibition that is cAMP dependent . Positive_regulation CTGF TGFB1 17428796 1742319 In gingival fibroblasts , the sole MAPK mediating the *stimulated* [CCN2/CTGF] expression is JNK . Positive_regulation CTGF TGFB1 17428796 1742320 Whereas forskolin reduces *stimulated* expression of [CCN2/CTGF] by 35 % and JNK activation in gingival fibroblasts , micromolar PGE ( 2 ) -stimulated JNK in gingival fibroblasts and opposes the inhibitory effects of cAMP on CCN2/CTGF expression . Positive_regulation CTGF TGFB1 17428796 1742321 Taken together , data identify two mechanisms by which *stimulated* [CCN2/CTGF] levels in human gingival fibroblasts resist down-regulation by PGE ( 2 ) : ( i ) cAMP cross-talk with MAPK pathways is limited in gingival fibroblasts ; Positive_regulation CTGF TGFB1 17876891 1796422 An intestinal stellate cell was immunocytochemically and biochemically characterized and its ( 10-7M ) *initiated* [CTGF] transcription response ( > 3-fold , P < 0.05 ) demonstrated . Positive_regulation CTGF TGFB1 17996907 1866775 Co-localization of TGF-beta1 and CTGF in activated fibroblasts suggests that [CTGF] expression is *regulated* by through a paracrine/autocrine mechanism . Positive_regulation CTGF TGFB1 18201696 1870325 In vitro , ( TGF-beta ) *induces* [CCN2] expression in mesenchymal cells . Positive_regulation CTGF TGFB1 18274641 1839824 In NRK/49F , *enhanced* [CTGF] , FN and Col III mRNA expression in a dose- and time dependent manner . Positive_regulation CTGF TGFB1 18274641 1839825 PPAR-gamma agonists could inhibit *induced* renal fibroblast activation , [CTGF] expression and ECM synthesis through abrogating the TGF-beta1/Smads signaling pathway . Positive_regulation CTGF TGFB1 18287089 1891390 ( TGFbeta1 ) *stimulates* connective tissue growth factor ( [CCN2/CTGF] ) expression in human gingival fibroblasts through a RhoA independent , Rac1/Cdc42 dependent mechanism : statins with forskolin block TGFbeta1 induced CCN2/CTGF expression . Positive_regulation CTGF TGFB1 18287089 1891392 TGFbeta1 does not stimulate RhoA activation in gingival fibroblasts , and the overexpression of dominant negative RhoA does not reduce [CCN2/CTGF] expression in *response* to . Positive_regulation CTGF TGFB1 18287089 1891396 Lovastatin and a geranylgeranyltransferase inhibitor reduce the *stimulated* levels of [CCN2/CTGF] protein by approximately 75 and 100 % , respectively . Positive_regulation CTGF TGFB1 18287089 1891397 We previously demonstrated that JNK1 phosphorylation by TGFbeta1 is also critical for *induced* [CCN2/CTGF] expression , and forskolin partially reduces levels of phosphorylated JNK1 . Positive_regulation CTGF TGFB1 18287089 1891399 This novel combination has additive inhibitory effects on the *stimulated* expression of [CCN2/CTGF] in human gingival fibroblasts through the simultaneous disruption of Rho- and JNK1 mediated pathways , respectively . Positive_regulation CTGF TGFB1 18303046 1878934 Thus , while L-endoglin decreased *induced* collagen I and [CTGF] expression and increased TGFbeta1 induced proliferation , S-endoglin strongly increased TGFbeta1 induced collagen I and CTGF expression , and reduced TGFbeta1 induced cell proliferation . Positive_regulation CTGF TGFB1 18314002 1897487 Molecular requirements for *induction* of [CTGF] expression by in primary osteoblasts . Positive_regulation CTGF TGFB1 18314002 1897489 In osteoblasts , [CTGF] is *induced* by where it acts as a downstream mediator of TGF-beta1 induced matrix production . Positive_regulation CTGF TGFB1 18314002 1897490 The molecular mechanisms that control [CTGF] *induction* by in osteoblasts are not known . Positive_regulation CTGF TGFB1 18314002 1897491 To assess the role of individual Smads in mediating the *induction* of [CTGF] by , we used specific Smad siRNAs to block Smad expression . Positive_regulation CTGF TGFB1 18314002 1897493 Since the activation of MAPKs ( Erk , Jnk and p38 ) by TGF-beta1 is cell type specific , we were interested in determining the role of individual MAPKs in *induction* of [CTGF] promoter activity and expression . Positive_regulation CTGF TGFB1 18314002 1897495 Using dominant negative ( DN ) mutants for Erk , Jnk and p38 , we demonstrated that the expression of DN-Erk caused a significant inhibition of *induced* [CTGF] promoter activity . Positive_regulation CTGF TGFB1 18314002 1897496 Since Src can also act as a downstream signaling effector for TGF-beta in some cell types , we determined its role in *induction* of [CTGF] in osteoblasts . Positive_regulation CTGF TGFB1 18314002 1897506 Using a combination of CTGF promoter deletion constructs and site directed mutants , we demonstrated the unique requirement of both the TRE and SBE for [CTGF] *induction* by in osteoblasts . Positive_regulation CTGF TGFB1 18314002 1897507 Electro-mobility shift assays using specific probes containing the TRE , SBE or both showed TGF-beta1 inducible complexes that can be ablated by mutation of the respective motif , confirming their requirement for *induced* [CTGF] promoter activity . Positive_regulation CTGF TGFB1 18314002 1897508 In conclusion , these studies demonstrate that [CTGF] *induction* by in osteoblasts involves Smads 3 and 4 , the Erk and Src signaling pathways , and requires both the TRE and SBE motifs in the CTGF proximal promoter . Positive_regulation CTGF TGFB1 18401334 1920305 In NRK-49F renal fibroblasts , adrenomedullin reduced *induced* [CTGF] and fibronectin mRNA upregulation through the cyclic AMP/protein kinase A signaling pathway , and suppressed ERK phosphorylation and cell proliferation . Positive_regulation CTGF TGFB1 18508967 1951851 In the HK-2 proximal tubule cell line , overexpression of IHG-1 increased *stimulated* expression of [connective tissue growth factor] and fibronectin . Positive_regulation CTGF TGFB1 18535390 1958881 [CTGF] expression is *induced* by in several cell types and CTGF mediates several of the downstream actions of TGF-beta(1) . Positive_regulation CTGF TGFB1 18586263 1946832 Adenoviral overexpression of KLF15 inhibits basal and *induced* [CTGF] expression in NRVFs . Positive_regulation CTGF TGFB1 18586263 1946835 From a mechanistic standpoint , KLF15 inhibits basal and *mediated* induction of the [CTGF] promoter . Positive_regulation CTGF TGFB1 18787533 2028360 Cell permeant peptide analogues of the small heat shock protein , HSP20 , reduce *induced* [CTGF] expression in keloid fibroblasts . Positive_regulation CTGF TGFB1 18787533 2028369 AZX100 decreased the expression of [CTGF] and type I collagen *induced* by , endothelin , and lysophosphatidic acid . Positive_regulation CTGF TGFB1 18922143 1982009 therefore *enhanced* [CCN2production] in an autocrine manner . Positive_regulation CTGF TGFB1 19024301 1992311 With the stimulation of , the expression of of [CTGF] protein and mRNA , as well as fibronectin and collagen I were markly *increased* ( P < 0.05 ) , which then were decreased by the treatment of PF. ( P < 0.05 ) . Positive_regulation CTGF TGFB1 19024302 1992313 The protein expression levels of a-smooth muscle actin ( alpha-SMA ) , [connective tissue growth factor (CTGF)] *induced* by were evaluated by immunocytochemistry . Positive_regulation CTGF TGFB1 19024302 1992314 The levels of a-SMA , [CTGF] mRNA expression *induced* by , were determined by quantitative real time fluroscent polymerase chain reaction . Positive_regulation CTGF TGFB1 19024302 1992316 may markedly *increase* the cell vitality , alpha-SMA and [CTGF] expression , FN and Col I protein expression ( P < 0.05 ) . Positive_regulation CTGF TGFB1 19056781 2053561 In RPTEC and HK-2 cells , significantly reduced e-cadherin expression and significantly *increased* vimentin , [CTGF] and TGF-beta1 expression . Positive_regulation CTGF TGFB1 19127219 2047788 The Smad2/3 pathway plays a key role in mediating inhibition of branching morphogenesis and *induction* of [connective tissue growth factor (CTGF)] expression in embryonic lungs . Positive_regulation CTGF TGFB1 19127219 2047790 Because a number of cell-specific interactions have been described between TGF-beta1-driven Smad signaling and the c-Jun N-terminal kinase (JNK) pathway , we have investigated the effects of JNK inhibition on activation of Smad2 , inhibition of branching , *induction* of [CTGF] expression , and apoptosis in mouse embryonic lung explants . Positive_regulation CTGF TGFB1 19127219 2047794 Treatment with JNK inhibitors also decreased normal branching morphogenesis and induced CTGF expression as well as augmented inhibition of branching and *induction* of [CTGF] expression . Positive_regulation CTGF TGFB1 19210343 2044307 In both human gingival fibroblasts and periodontal ligament cells , the expression of CCN2/CTGF mRNA and [CCN2/CTGF] protein was significantly increased , in a dose- and time dependent manner , in the *presence* of . Positive_regulation CTGF TGFB1 19289101 2055899 In addition , 10 microM MK2i decreased *induced* expression of [connective tissue growth factor] and collagen type I within serum starved keloid fibroblasts . Positive_regulation CTGF TGFB1 19355909 2058067 *mediated* activation of [CTGF] gene expression is controlled by Smads , but recently Rho/ROCK signaling has emerged as an alternative pathway involved in the control of CTGF expression in intestinal fibrosis . Positive_regulation CTGF TGFB1 19358180 2058224 treatment of fibroblasts *induced* smad-2/3 phosphorylation , [CTGF] and collagen-Ialpha2 production , F-actin bundling , FPCL contraction and PAI-1 activation . Positive_regulation CTGF TGFB1 19466435 2107401 Activation of peroxisome proliferator activated receptor-gamma inhibits *induction* of [connective tissue growth factor] and extracellular matrix in hypertrophic scar fibroblasts in vitro . Positive_regulation CTGF TGFB1 19466435 2107402 In growth arrested HSFs , a PPAR-gamma natural ligand ( 15-deoxy-D12,14-prostaglandin J2 , 15d-PGJ2 ) and a synthetic ligand ( GW7845 ) dose-dependently attenuated *induced* expression of [Connective tissue growth factor (CTGF)] , collagens and fibronectin . Positive_regulation CTGF TGFB1 19494553 2098056 The aims of this study were to investigate the role of the Ras/MAP kinase pathway in TGFbeta1 inhibition of proliferation , TGFbeta auto-induction and *induced* [CTGF] expression in HKC human renal tubule epithelial cells . Positive_regulation CTGF TGFB1 19494553 2098057 *increased* cellular and secreted [CTGF] protein in HKC cells in a MEK dependent manner . Positive_regulation CTGF TGFB1 19494553 2098073 Only inhibition of N-Ras resulted in a significant reduction of auto induced TGFbeta1 secretion and *induced* cellular and secreted [CTGF] . Positive_regulation CTGF TGFB1 19494553 2098075 These results establish that the Ras/MAP kinase pathway , specifically through N-Ras , mediates TGFbeta1 auto-induction and *induced* [CTGF] expression in human renal tubule epithelial cells . Positive_regulation CTGF TGFB1 19565505 2104338 [CTGF] is *induced* by ( TGFbeta ) and is a mediator of some profibrotic effects of TGFbeta in vitro . Positive_regulation CTGF TGFB1 19589256 2105283 The role of c-Jun N-terminal kinases 1/2 in *induced* expression of [connective tissue growth factor] and scar formation in the cornea . Positive_regulation CTGF TGFB1 19620052 2112583 [ Peroxisome proliferator activated receptor gamma inhibits *induced* [connective tissue growth factor] expression in rat hepatic stellate cells ] . Positive_regulation CTGF TGFB1 19620052 2112584 15-d-PGJ2 and GW7845 significantly inhibited *induced* [CTGF] expression at both mRNA and protein levels in HSCs , and the inhibitory effect was dramatically , if not completely , abolished by pretreatment with GW9662 , suggesting that the inhibition was mediated by PPARgamma . Positive_regulation CTGF TGFB1 19620052 2112585 PPARgamma ligand shows potent inhibitory effect on *induced* [CTGF] expression in rat HSCs , suggesting its potential as a candidate agent for treatment and prevention of hepatic fibrosis . Positive_regulation CTGF TGFB1 19763793 2195473 JNK1/2 siRNA inhibits *induced* [connective tissue growth factor] expression and fibrotic function in THSFs . Positive_regulation CTGF TGFB1 19763793 2195474 In this paper , real-time RT-PCR and Western blot analysis were used to examine the expression and induced *upregulation* of [CTGF] in telomerase immortalized human cornea stroma fibroblast cells ( THSFs ) . Positive_regulation CTGF TGFB1 19764552 2140669 To investigate the expression of [CTGF] , CTGF mRNA , NF-kappaB and AP-1 *induced* by in human lung fibroblast ( HLF-02 ) , and study the effect and possible mechanism of rosiglitazone on signal pathways of TGF-beta1 in HLF-02 . Positive_regulation CTGF TGFB1 19764552 2140677 It is supposed that rosiglitazone inhibits [CTGF] expression *induced* by in HLF-02 cells by activating PPARgamma through NF-kappaB and AP-1 signal transduction pathways . Positive_regulation CTGF TGFB1 19789541 2141582 A well established pathway implicated in the progression of fibrosis is the *induction* of [connective tissue growth factor] by , resulting in the accumulation of extracellular matrix proteins . Positive_regulation CTGF TGFB1 19821534 2196030 A ( TGF-beta ) receptor inhibitor , LY2109761 , *inhibited* the synthesis and release of [CTGF] , as well as reducing the stromal component of the tumors . Positive_regulation CTGF TGFB1 19947172 2167721 The present study was designed to investigate the potential mechanism of fluorofenidone involving the downregulation of [CTGF] expression *induced* by and the related signaling pathway in mouse mesangial cells ( MMCs ) . Positive_regulation CTGF TGFB1 19947172 2167724 Fluorofenidone , PD98059 and SB203580 could partially inhibit *induced* expression of [CTGF] in mouse mesangial cells , however , JNK inhibitor II had no effect . Positive_regulation CTGF TGFB1 19957515 2172833 [ Effects of bone morphogenic protein-7 on transdifferentiation and the expression of [connective tissue growth factor] of human renal tubular epithelial cells *induced* by ] . Positive_regulation CTGF TGFB1 20067105 2177753 This implied that matrine inhibit the expression of [CTGF] and CTGF mRNA *induced* by through the Smad2 and ERK signal transduction pathways . Positive_regulation CTGF TGFB1 20393108 2319804 [Connective tissue growth factor (CTGF)] is *induced* by ( TGF-ß ) after corneal wounding . Positive_regulation CTGF TGFB1 20432467 2282443 Src is a major signaling component for [CTGF] *induction* by in osteoblasts . Positive_regulation CTGF TGFB1 20432467 2282444 [Connective tissue growth factor] ( CTGF/CCN2 ) is *induced* by ( TGF-beta1 ) where it acts as a downstream mediator of TGF-beta1 induced matrix production in osteoblasts . Positive_regulation CTGF TGFB1 20432467 2282445 We have shown the requirement of Src , Erk , and Smad signaling for [CTGF] *induction* by in osteoblasts ; Positive_regulation CTGF TGFB1 20432467 2282450 When we treated cells with the Erk inhibitor , PD98059 , it inhibited *induced* [CTGF] protein expression but had no effect on Src activation , Smad activation or Smad nuclear translocation . Positive_regulation CTGF TGFB1 22312703 2520685 AKF-PD acts as an anti-fibrotic agent through blocking TGF-beta/Smads signaling and consequently inhibits *induced* EMT and [CTGF] expression in human proximal tubular epithelial cells . Positive_regulation CTGF TGFB1 9925376 559372 [Connective tissue growth factor (CTGF)] , a 36- to 38-kDa peptide , is selectively *induced* by and has been suggested to contribute to tissue repair . Positive_regulation CTGF TGFB2 10098490 601634 Intact [CTGF] was *increased* by cAMP but not by ( TGFbeta ) . Positive_regulation CTGF TGFB2 10809757 692604 Tumor necrosis factor alpha suppresses the *induction* of [connective tissue growth factor] by in normal and scleroderma fibroblasts . Positive_regulation CTGF TGFB2 10976101 751899 Induction of CTGF mRNA was transient with maximal expression after 1 to 2 h , whereas *induction* of [CTGF] by ( TGF-beta ) increased over time . Positive_regulation CTGF TGFB2 11152469 795348 In normal adult fibroblasts , ( TGFbeta ) *induces* the expression of [connective tissue growth factor (CTGF)] . Positive_regulation CTGF TGFB2 11518710 868661 [Connective tissue growth factor (CTGF)] expression is *regulated* by ( TGF-beta ) and strong up-regulation occurs during wound healing ; Positive_regulation CTGF TGFB2 11590167 882905 Peroxisome proliferator activated receptor gamma inhibits *induced* [connective tissue growth factor] expression in human aortic smooth muscle cells by interfering with Smad3 . Positive_regulation CTGF TGFB2 11874477 918784 [Connective tissue growth factor] , which is *induced* by , has been reported to mediate the stimulatory actions of transforming growth factor beta on type I procollagen synthesis . Positive_regulation CTGF TGFB2 12368229 1019218 The SMAD mediated *induction* of [connective tissue growth factor (CTGF)] , a fibroproliferative cytokine , by is required for the development of sustained fibrosis in humans . Positive_regulation CTGF TGFB2 12368229 1019228 Here , we show that in fibroblasts , activation of the Ras/MEK/ERK pathway is required for the SMAD mediated *induction* of [CTGF] by . Positive_regulation CTGF TGFB2 15192102 1281003 Furthermore , the expression of [connective tissue growth factor] is *enhanced* by both and S1P . Positive_regulation CTGF TGFB2 15298857 1322230 [Connective tissue growth factor] expression and *induction* by is abrogated by simvastatin via a Rho signaling mechanism . Positive_regulation CTGF TGFB2 15862293 1400932 [Connective tissue growth factor (CTGF)] is *induced* by ( TGF-beta ) via Smad activation in mesangial cells . Positive_regulation CTGF TGFB2 15980944 1424712 [Connective tissue growth factor] *mediates* the profibrotic effects of produced by tubular epithelial cells in response to high glucose . Positive_regulation CTGF TGFB2 16198104 1468460 *enhances* [connective tissue growth factor] expression in L6 rat skeletal myotubes . Positive_regulation CTGF TGFB2 16484225 1548585 [CCN2] is *induced* by ( TGFbeta ) in fibroblasts and is overexpressed in connective tissue disease . Positive_regulation CTGF TGFB2 16611331 1545312 *induced* [connective tissue growth factor] and chronic allograft rejection . Positive_regulation CTGF TGFB2 16636587 1583075 Previous studies found that ( TGF-beta ) *induces* mesothelial production of [connective tissue growth factor (CTGF)] , which may be downstream mediators of TGF-beta . Positive_regulation CTGF TGFB2 17133596 1661433 SPARC , an upstream regulator of [connective tissue growth factor] in *response* to stimulation . Positive_regulation CTGF TGFB2 17192487 1680332 *dependent* Smad4 translocation and [CTGF] gene expression were mediated through Rho kinase and at least partially via p38 mitogen activated protein kinase . Positive_regulation CTGF TGFB2 18201696 1870326 In vitro , ( TGF-beta ) *induces* [CCN2] expression in mesenchymal cells . Positive_regulation CTGF TGFB2 18401334 1920306 In NRK-49F renal fibroblasts , adrenomedullin reduced *induced* [CTGF] and fibronectin mRNA upregulation through the cyclic AMP/protein kinase A signaling pathway , and suppressed ERK phosphorylation and cell proliferation . Positive_regulation CTGF TGFB2 18683703 1949070 [ Influence of ASODN to the human tenon 's fibroblasts in expressing [CTGF] *induced* by ] . Positive_regulation CTGF TGFB2 19450452 2084399 Transfection with CTGF-specific siRNA inhibited the *induced* upregulation of [CTGF] and fibronectin . Positive_regulation CTGF TGFB2 19450457 2084403 Following combined BMP7/TGF-beta2 treatment , the antagonizing effect of BMP7 on *induced* [CTGF] expression was abolished . Positive_regulation CTGF TGFB2 19565505 2104339 [CTGF] is *induced* by ( TGFbeta ) and is a mediator of some profibrotic effects of TGFbeta in vitro . Positive_regulation CTGF TGFB2 19789541 2141583 A well established pathway implicated in the progression of fibrosis is the *induction* of [connective tissue growth factor] by , resulting in the accumulation of extracellular matrix proteins . Positive_regulation CTGF TGFB2 19821534 2196031 A ( TGF-beta ) receptor inhibitor , LY2109761 , *inhibited* the synthesis and release of [CTGF] , as well as reducing the stromal component of the tumors . Positive_regulation CTGF TGFB2 20393108 2319805 [Connective tissue growth factor (CTGF)] is *induced* by ( TGF-ß ) after corneal wounding . Positive_regulation CTGF TGFB2 23116564 2703762 ( TGFß2 ) *induced* the expression of fibronectin (FN) , plasminogen activator inhibitor-1 ( PAI-1 ) , and [connective tissue growth factor (CTGF)] in our cell cultures . Positive_regulation CTGF TGFB2 9925376 559373 [Connective tissue growth factor (CTGF)] , a 36- to 38-kDa peptide , is selectively *induced* by and has been suggested to contribute to tissue repair . Positive_regulation CTGF TGFB3 10098490 601635 Intact [CTGF] was *increased* by cAMP but not by ( TGFbeta ) . Positive_regulation CTGF TGFB3 10809757 692605 Tumor necrosis factor alpha suppresses the *induction* of [connective tissue growth factor] by in normal and scleroderma fibroblasts . Positive_regulation CTGF TGFB3 10976101 751900 Induction of CTGF mRNA was transient with maximal expression after 1 to 2 h , whereas *induction* of [CTGF] by ( TGF-beta ) increased over time . Positive_regulation CTGF TGFB3 11148815 761009 FCS , TGF-beta 1 , , bFGF , and EGF *induced* an upregulation of [CTGF] gene expression in RVEC in a time dependent manner . Positive_regulation CTGF TGFB3 11152469 795349 In normal adult fibroblasts , ( TGFbeta ) *induces* the expression of [connective tissue growth factor (CTGF)] . Positive_regulation CTGF TGFB3 11518710 868662 [Connective tissue growth factor (CTGF)] expression is *regulated* by ( TGF-beta ) and strong up-regulation occurs during wound healing ; Positive_regulation CTGF TGFB3 11590167 882906 Peroxisome proliferator activated receptor gamma inhibits *induced* [connective tissue growth factor] expression in human aortic smooth muscle cells by interfering with Smad3 . Positive_regulation CTGF TGFB3 11874477 918785 [Connective tissue growth factor] , which is *induced* by , has been reported to mediate the stimulatory actions of transforming growth factor beta on type I procollagen synthesis . Positive_regulation CTGF TGFB3 12368229 1019219 The SMAD mediated *induction* of [connective tissue growth factor (CTGF)] , a fibroproliferative cytokine , by is required for the development of sustained fibrosis in humans . Positive_regulation CTGF TGFB3 15298857 1322231 [Connective tissue growth factor] expression and *induction* by is abrogated by simvastatin via a Rho signaling mechanism . Positive_regulation CTGF TGFB3 15862293 1400933 [Connective tissue growth factor (CTGF)] is *induced* by ( TGF-beta ) via Smad activation in mesangial cells . Positive_regulation CTGF TGFB3 15980944 1424713 [Connective tissue growth factor] *mediates* the profibrotic effects of produced by tubular epithelial cells in response to high glucose . Positive_regulation CTGF TGFB3 16198104 1468461 *enhances* [connective tissue growth factor] expression in L6 rat skeletal myotubes . Positive_regulation CTGF TGFB3 16484225 1548586 [CCN2] is *induced* by ( TGFbeta ) in fibroblasts and is overexpressed in connective tissue disease . Positive_regulation CTGF TGFB3 16611331 1545313 *induced* [connective tissue growth factor] and chronic allograft rejection . Positive_regulation CTGF TGFB3 16636587 1583076 Previous studies found that ( TGF-beta ) *induces* mesothelial production of [connective tissue growth factor (CTGF)] , which may be downstream mediators of TGF-beta . Positive_regulation CTGF TGFB3 16772929 1572857 *induced* more than 70-fold , 50-fold , and 20-fold increases in [CTGF] expression in E17 , E19 , and adult fibroblasts , respectively ( p < 0.01 for each ) . Positive_regulation CTGF TGFB3 17133596 1661434 SPARC , an upstream regulator of [connective tissue growth factor] in *response* to stimulation . Positive_regulation CTGF TGFB3 18201696 1870327 In vitro , ( TGF-beta ) *induces* [CCN2] expression in mesenchymal cells . Positive_regulation CTGF TGFB3 18401334 1920307 In NRK-49F renal fibroblasts , adrenomedullin reduced *induced* [CTGF] and fibronectin mRNA upregulation through the cyclic AMP/protein kinase A signaling pathway , and suppressed ERK phosphorylation and cell proliferation . Positive_regulation CTGF TGFB3 19565505 2104340 [CTGF] is *induced* by ( TGFbeta ) and is a mediator of some profibrotic effects of TGFbeta in vitro . Positive_regulation CTGF TGFB3 19789541 2141584 A well established pathway implicated in the progression of fibrosis is the *induction* of [connective tissue growth factor] by , resulting in the accumulation of extracellular matrix proteins . Positive_regulation CTGF TGFB3 19821534 2196032 A ( TGF-beta ) receptor inhibitor , LY2109761 , *inhibited* the synthesis and release of [CTGF] , as well as reducing the stromal component of the tumors . Positive_regulation CTGF TGFB3 20393108 2319806 [Connective tissue growth factor (CTGF)] is *induced* by ( TGF-ß ) after corneal wounding . Positive_regulation CTGF TGFB3 9925376 559374 [Connective tissue growth factor (CTGF)] , a 36- to 38-kDa peptide , is selectively *induced* by and has been suggested to contribute to tissue repair . Positive_regulation CTGF THBS1 16869004 1607360 These results document a *role* for in regulating [CTGF] gene and protein expression in synovial tissue , suggesting a link with the disease course in this model of RA . Positive_regulation CTGF THBS1 17219411 1703031 Both inflammation and angiogenesis were decreased after TSP1 derived peptide treatment indicating a potential pathway by which interaction with neutrophils *induces* [CTGF] in RA affected tissues . Positive_regulation CTGF THBS1 19385040 2069255 The action of TGF-betas very likely requires local activation by and is partly *mediated* by its downstream mediator [connective tissue growth factor] , both of which are constitutively expressed in the trabecular meshwork . Positive_regulation CTGF TNF 12787426 1097008 In contrast , platelet derived growth factor ( PDGF ) , epidermal growth factor (EGF) , and *had* no measurable effects on [CTGF] mRNA expression . Positive_regulation CTGF TNF 17376761 1766028 , but not IFN-gamma , *regulates* [CCN2] ( CTGF ) , collagen type I , and proliferation in mesangial cells : possible roles in the progression of renal fibrosis . Positive_regulation CTGF TNF 17376761 1766032 combined with TGF-beta further *increased* [CCN2] secretion and mRNA levels and reduced proliferation . Positive_regulation CTGF TNF 17376761 1766033 The *stimulation* of [CCN2] release by , unlike TGF-beta , is independent of cellular proliferation and not linked to increased collagen type I accumulation . Positive_regulation CTGF TNF 18639630 1954659 Transforming growth factor-beta1 , activin A and *enhanced* expression of the [CTGF] gene , while interferon-gamma displayed the opposite effect . Positive_regulation CTGF TNF 19922639 2176244 In addition , can *induce* the [CTGF] production from synovial fibroblasts even though TNFalpha can oppositely inhibit the production of CTGF from chondrocytes . Positive_regulation CTGF TNF 19922639 2176245 These results indicate that aberrant [CTGF] production *induced* by plays a central role for the abnormal osteoclastic activation in RA patients . Positive_regulation CTGF TNFRSF11B 23722620 2853923 Our results revealed that [CTGF] *induced* the expression of several bone markers , including alkaline phosphatase (ALP) , osteocalcin (OC) , and core binding factor subunit a1 ( Cbfa1 ) /runt related transcription factor 2 ( Runx2 ) , as well as calcification . Positive_regulation CTGF TP53 21747166 2461760 This study reveals that *induces* [CTGF] expression and promotes liver fibrosis , suggesting that the p53/CTGF pathway may be a therapeutic target in the treatment of liver fibrosis . Positive_regulation CTGF TP53 23048035 2702756 [CTGF/CCN2] effects on abnormal vessel formation in the retina are *mediated* by and MMP-2 . Positive_regulation CTGF UCN 18587447 1931178 Moreover , *inhibited* the overexpression of transforming growth factor-beta 1 and [connective tissue growth factor] in rat mesangial cells induced by 25 mM glucose . Positive_regulation CTGF VEGFA 11018037 752824 *induces* expression of [connective tissue growth factor] via KDR , Flt1 , and phosphatidylinositol 3-kinase-akt dependent pathways in retinal vascular cells . Positive_regulation CTGF VEGFA 11018037 752825 Since connective tissue growth factor (CTGF) is a potent mitogen for fibrosis , extracellular matrix production , and angiogenesis , we have studied the effects and mechanism by which ( VEGF ) *regulates* [CTGF] gene expression in retinal capillary cells . Positive_regulation CTGF VEGFA 11018037 752827 In our study , *increased* [CTGF] mRNA levels in a time- and concentration dependent manner in bovine retinal endothelial cells and pericytes , without the need of new protein synthesis and without altering mRNA stability . Positive_regulation CTGF VEGFA 11018037 752830 *induced* [CTGF] expression was mediated primarily by PI3-kinase activation , whereas PKC and ERK pathways made only minimal contributions . Positive_regulation CTGF VEGFA 11018037 752835 Furthermore , overexpression of constitutive active Akt was sufficient to induce CTGF gene expression , and inhibition of Akt activation by overexpressing dominant negative mutant of Akt abolished the *induced* [CTGF] expression . Positive_regulation CTGF VEGFA 11018037 752836 These data suggest that can *increase* [CTGF] gene expression in bovine retinal capillary cells via KDR or Flt receptors and the activation of PI3-kinase-Akt pathway independently of PKC or Ras-ERK pathway , possibly inducing the fibrosis observed in retinal neovascular diseases . Positive_regulation CTGF VEGFA 15258030 1272376 It has a role in the pathogenesis of diabetic nephropathy and possibly in diabetic retinopathy ( DR ) : in cultured retinal vascular cells [CTGF] is *induced* by . Positive_regulation CTGF VEGFA 16432171 1516249 Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional *induction* of [connective tissue growth factor] ( CTGF/CCN2 ) by in human endothelial cells . Positive_regulation CTGF VEGFA 18835464 2012843 We have demonstrated that *regulates* the expression of CCN2/connective tissue growth factor ( [CCN2/CTGF] ) an essential mediator of cartilage development and angiogenesis , suggesting that CCN2 functions in down-stream of VEGF , and that VEGF function is mediated in part by CCN2 . Positive_regulation CTGF WNT1 20299474 2281628 Dickkopf-1 , a specific Wnt antagonist , also attenuated the high-glucose induced CTGF overexpression , indicating a *role* of signaling in [CTGF] overexpression in diabetes . Positive_regulation CTGF WNT10B 19353303 2081091 *activates* the [CCN2] promoter in NIH 3T3 fibroblasts through the Smad response element . Positive_regulation CTGF WNT10B 19353303 2081092 *activates* the [CCN2] minimal promoter . Positive_regulation CTGF WNT11 20299474 2281629 Dickkopf-1 , a specific Wnt antagonist , also attenuated the high-glucose induced CTGF overexpression , indicating a *role* of signaling in [CTGF] overexpression in diabetes . Positive_regulation CTGF WNT16 20299474 2281634 Dickkopf-1 , a specific Wnt antagonist , also attenuated the high-glucose induced CTGF overexpression , indicating a *role* of signaling in [CTGF] overexpression in diabetes . Positive_regulation CTGF WNT2 20299474 2281630 Dickkopf-1 , a specific Wnt antagonist , also attenuated the high-glucose induced CTGF overexpression , indicating a *role* of signaling in [CTGF] overexpression in diabetes . Positive_regulation CTGF WNT3 20299474 2281631 Dickkopf-1 , a specific Wnt antagonist , also attenuated the high-glucose induced CTGF overexpression , indicating a *role* of signaling in [CTGF] overexpression in diabetes . Positive_regulation CTGF WNT4 20299474 2281632 Dickkopf-1 , a specific Wnt antagonist , also attenuated the high-glucose induced CTGF overexpression , indicating a *role* of signaling in [CTGF] overexpression in diabetes . Positive_regulation CTGF WNT6 20299474 2281633 Dickkopf-1 , a specific Wnt antagonist , also attenuated the high-glucose induced CTGF overexpression , indicating a *role* of signaling in [CTGF] overexpression in diabetes . Positive_regulation CTLA4 ADRB2 23436577 2771373 Moreover , signaling *increased* [CTLA-4] expression in Treg cells in a PKA dependent way . Positive_regulation CTLA4 FAS 12717632 1083903 Together , these data show that apoptosis *mediated* by and engagement of [CTLA-4] are involved in modulation of the immune response in patients infected with Paracoccidioides brasiliensis . Positive_regulation CTLA4 NT5E 23983257 2851011 Targeting *enhances* the antitumor activity of anti-PD-1 and [anti-CTLA-4] mAbs . Positive_regulation CTLA4 TNF 23634660 2790766 The engagement of [CTLA-4] on primary melanoma cell lines *induces* antibody dependent cellular cytotoxicity and production . Positive_regulation CTNNB1 ANGPT1 14584044 1187142 In contrast , *enhanced* the interaction of [beta-catenin] with VE-cadherin and impaired VEGF mediated dissociation of this complex . Positive_regulation CTNNB1 AXIN2 10196136 604285 forms a complex with glycogen synthase kinase-3beta ( GSK-3beta ) and beta-catenin and *promotes* GSK-3beta dependent phosphorylation of [beta-catenin] , thereby stimulating the degradation of beta-catenin . Positive_regulation CTNNB1 AXIN2 10330181 614242 Although expression of in SW480 cells *caused* the degradation of [beta-catenin] and reduced the cell growth rate , expression of an Axin mutant that lacks the DIX domain did not affect the level of beta-catenin or the growth rate . Positive_regulation CTNNB1 AXIN2 10330403 614371 Some forms of lacking the beta-catenin binding site can still interact indirectly with beta-catenin and *regulate* [beta-catenin] levels and axis formation . Positive_regulation CTNNB1 AXIN2 10481074 643642 The *dependent* phosphorylation of [beta-catenin] catalysed by glycogen synthase kinase-3 (GSK3) is inhibited during embryogenesis . Positive_regulation CTNNB1 AXIN2 10488109 645224 , a Wnt signal negative regulator , *enhances* glycogen synthase kinase (GSK)-3beta dependent phosphorylation of [beta-catenin] and stimulates the degradation of beta-catenin . Positive_regulation CTNNB1 AXIN2 10722668 677133 In the present study , we examined whether APC association with is *required* for degradation of [beta-catenin] . Positive_regulation CTNNB1 AXIN2 10811618 693075 In the absence of Wnt signal , and APC *regulate* cytoplasmic levels of the proto-oncogene [beta-catenin] through the formation of a large complex containing these three proteins , glycogen synthase kinase 3beta ( GSK3beta ) and several other proteins . Positive_regulation CTNNB1 AXIN2 10966653 728210 Interactions between beta-catenin and LEF-1/TCF , APC and are *essential* for wnt controlled stabilization of [beta-catenin] and transcriptional activation . Positive_regulation CTNNB1 AXIN2 10966653 728214 Moreover , we demonstrate that binding to beta-catenin is *essential* for [beta-catenin] degradation , and that APC acts as a cofactor of conductin/axin in this process . Positive_regulation CTNNB1 AXIN2 11738041 885906 This inhibits the *dependent* phosphorylation of [beta-catenin] by GSK-3 . Positive_regulation CTNNB1 AXIN2 11809808 906695 [Wnt/beta-catenin/Tcf] signaling *induces* the transcription of , a negative regulator of the signaling pathway . Positive_regulation CTNNB1 AXIN2 11956582 931205 The wnt pathway plays an important role in embryonal patterning and cell fate determination , involving stabilization of nuclear and cytoplasmic [beta-catenin] ( CTNNB1 ) *mediated* by APC , , and other proteins . Positive_regulation CTNNB1 AXIN2 11970895 933222 Overexpression of Dapper increases and GSK-3 in this complex , *resulting* in decreased soluble beta-catenin and decreased activation of [beta-catenin-responsive] genes . Positive_regulation CTNNB1 AXIN2 12000790 939829 *mediated* CKI phosphorylation of [beta-catenin] at Ser 45 : a molecular switch for the Wnt pathway . Positive_regulation CTNNB1 AXIN2 14981260 1214319 Nuclear-cytoplasmic shuttling of *regulates* subcellular localization of [beta-catenin] . Positive_regulation CTNNB1 AXIN2 15063782 1230966 , a negative regulator of Wnt , forms a complex with glycogen synthase kinase 3beta , beta-catenin , and adenomatous polyposis coli and *promotes* GSK3beta dependent phosphorylation of [beta-catenin] , thereby stimulating degradation of the beta-catenin . Positive_regulation CTNNB1 AXIN2 15228590 1268993 Thereby , S-SCAM inhibited the *mediated* phosphorylation of [beta-catenin] by GSK3beta . Positive_regulation CTNNB1 AXIN2 16616828 1624478 Here we report that IKKalpha could inhibit [beta-catenin] degradation *mediated* not only by the complex , but also by the Siah-1 pathway . Positive_regulation CTNNB1 AXIN2 17202189 1680716 [Wnt11/beta-catenin] signaling in both oocytes and early embryos *acts* through LRP6 mediated regulation of . Positive_regulation CTNNB1 AXIN2 19075000 2030699 N-cadherin interacts with and LRP5 to negatively *regulate* [Wnt/beta-catenin] signaling , osteoblast function , and bone formation . Positive_regulation CTNNB1 AXIN2 19075000 2030800 These data indicate that a previously unrecognized interaction negatively *regulates* [Wnt/beta-catenin] signaling and is critical in the regulation of osteoblast function , bone formation , and bone mass . Positive_regulation CTNNB1 AXIN2 19293931 2051641 In this study , we reconstituted *dependent* [beta-catenin] phosphorylation by GSK3 and CK1 in vitro using recombinant proteins , and found that the phosphorylated PPPSPXS peptides directly inhibit beta-catenin phosphorylation by GSK3 in a sequence and phosphorylation dependent manner . Positive_regulation CTNNB1 AXIN2 19888210 2161364 We show that Ube2m interacts with and modulates [beta-catenin] stability , and that the antagonistic effect of Nkd1 on Wnt signaling *requires* interaction with , itself a negative pathway regulator . Positive_regulation CTNNB1 AXIN2 9554852 499568 *induced* [beta-catenin] degradation , whereas mutants of conductin that were deficient in complex formation stabilized beta-catenin . Positive_regulation CTNNB1 AXIN2 9556553 499829 Furthermore , *stimulated* the degradation of [beta-catenin] in COS cells . Positive_regulation CTNNB1 AXIN2 9556553 499834 Taken together with our recent observations that directly interacts with glycogen synthase kinase-3beta ( GSK-3beta ) and beta-catenin and that it *promotes* GSK-3beta dependent phosphorylation of [beta-catenin] , these results suggest that Axin , APC , GSK-3beta , and beta-catenin make a tetrameric complex , resulting in the regulation of the stabilization of beta-catenin . Positive_regulation CTNNB1 CAPN8 12239346 992719 Ca ( 2+ ) release from internal stores results in nuclear export and *mediated* degradation of [beta-catenin] in the cytoplasm . Positive_regulation CTNNB1 CAPN8 12239346 992733 We conclude that Gq signaling promotes nuclear export and *mediated* degradation of [beta-catenin] , which therefore contributes to the inhibition of Wnt/beta-catenin pathway . Positive_regulation CTNNB1 CAPN8 17270735 1691703 Here , we show that , in hippocampal neurons , NMDA-receptor dependent activation of *induced* the cleavage of [beta-catenin] at the N terminus , generating stable , truncated forms . Positive_regulation CTNNB1 CCND1 10318916 611983 protein levels were *induced* by [beta-catenin] overexpression and reduced in cells overexpressing the cadherin cytoplasmic domain . Positive_regulation CTNNB1 CCND1 14688030 1218836 Using immunohistochemistry [beta-catenin] ( encoded by Catnb ) protein accumulation was *detected* in 80 % ( 8/10 ) of the cecal carcinomas , while increased and p53 protein expression was detected in 73 % ( 8/11 ) , respectively . Positive_regulation CTNNB1 CCND1 15004225 1237024 Our results show that low concentrations of DCA ( 5 and 50 microM ) significantly increase tyrosine phosphorylation of [beta-catenin] , *induce* urokinase-type plasminogen activator , uPAR , and expression and enhance colon cancer cell proliferation and invasiveness . Positive_regulation CTNNB1 CCND1 16288056 1481241 Treatment of HT29 human colon cancer cells with EGCG ( 12.5 or 20 micromol/L at different times ) also increased protein levels of E-cadherin by 27 % to 58 % , *induced* the translocation of [beta-catenin] from nucleus to cytoplasm and plasma membrane , and decreased c-Myc and ( 20 micromol/L EGCG for 24 hours ) . Positive_regulation CTNNB1 CCND1 16465433 1523341 In support of this prediction , we observed nuclear [beta-catenin] accumulation and *induction* in breast cancer cell lines , but not in HMEC . Positive_regulation CTNNB1 F2R 15935773 1415059 Depletion of PAR-1A or *causes* dorsoanterior deficits , reduced Spemann organizer gene expression , and inhibition of canonical [Wnt-beta-catenin] signaling . Positive_regulation CTNNB1 FGFBP1 14678957 1179009 Also , in cell culture studies is *induced* by [beta-catenin] through direct activation of the FGF-BP gene promoter . Positive_regulation CTNNB1 FZD4 16236168 1483669 It is not known how can *activate* [Wnt/beta-catenin] signaling and what biological role this molecule plays in vivo . Positive_regulation CTNNB1 FZD4 19020754 1992179 Functionally , expression modulates apoptosis and *enhances* Wnt3a induced [beta-catenin] stability in myeloid progenitor cells . Positive_regulation CTNNB1 FZD4 21850537 2524307 Interestingly , we did not find any nuclear immuno-reactivity to CTNNB1 in four MBs over expressing both FZD2 and other FZD receptors , confirming the lack of nuclear [CTNNB1] staining in the *presence* of increased expression , as in other tumor types . Positive_regulation CTNNB1 IL1B 12147254 970008 increased expression of COX-2 and *induced* accumulation and nuclear translocation of transcriptionally competent [beta-catenin] . Positive_regulation CTNNB1 IL1B 19701245 2158069 Constitutive activation of signal transducer and activator of transcription ( STAT ) 1 in THP1 macrophages was essential for the induction of and thus for the *activation* of [beta-catenin] signaling in tumor cells . Positive_regulation CTNNB1 JAG1 17474126 1743985 The Notch pathway is required for hair follicle maintenance and is activated through [beta-catenin] *induced* transcription of the Notch ligand . Positive_regulation CTNNB1 JAG1 17568183 1815731 [WNT-beta-catenin-TCF/LEF] signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , and DKK1 genes . Positive_regulation CTNNB1 MAP2K6 16478791 1528377 The *activation* of Raf1 , and ERK kinases by [beta-catenin] was reduced by co-expression of APC . Positive_regulation CTNNB1 MAP2K6 20089873 2258692 In addition , the VEGF induced transcriptional activation of [beta-catenin] and uPAR expression were *blocked* by PEDF and by inhibitors of p38 and . Positive_regulation CTNNB1 MMP28 12507936 1027401 These inhibitors also *blocked* the cytosolic accumulation of [beta-catenin] and nuclear formation of beta-catenin/LEF-1 complex . Positive_regulation CTNNB1 MMP7 12507936 1027416 These inhibitors also *blocked* the cytosolic accumulation of [beta-catenin] and nuclear formation of beta-catenin/LEF-1 complex . Positive_regulation CTNNB1 MMP7 19360357 2058564 TGFbeta1 dependent , *mediated* up-regulation of [beta-catenin/LEF1] signaling and TGFbeta1 activated HMGA2 pathways consequently converged with Slug overexpression , due to disassembly and further repression of E-cadherin expression , which was reproducible in the epithelial mesenchymal transition process without any manipulation . Positive_regulation CTNNB1 MMP7 20677010 2311817 Here , we report that hepatocyte growth factor (HGF) induced E-cadherin downregulation and cell scattering are attributed to the activation of [Wnt/beta-catenin] signaling and transcriptional *activation* of matrix metalloproteinase . Positive_regulation CTNNB1 PECAM1 10801826 707972 Recently we demonstrated that association functions to *regulate* [beta-catenin] localization and , moreover , to modulate beta-catenin tyrosine phosphorylation levels . Positive_regulation CTNNB1 PECAM1 12646189 1069871 Additionally , we demonstrate that lacking the majority of the cytoplasmic domain *promotes* significantly less accumulation of transcriptionally active [beta-catenin] than full-length PECAM-1 . Positive_regulation CTNNB1 PLAT 15695395 1371833 *dependent* [beta-catenin] activation is mediated through epidermal growth factor receptor (EGFR) transactivation ( via Src ) , suggested by the inhibitory effects of AG1478 and PP2 ( specific inhibitors of EGFR and Src , respectively ) and by the lack of beta-catenin activation in EGFR negative B82 fibroblasts . Positive_regulation CTNNB1 PLAU 12958170 1138184 Here we provide evidence that PGE2 transactivates c-Met-R ( contingent upon functional EGFR ) , increases tyrosine phosphorylation and nuclear accumulation of [beta-catenin] , and *induces* receptor ( uPAR ) mRNA expression . Positive_regulation CTNNB1 PLAU 15004225 1237025 Our results show that low concentrations of DCA ( 5 and 50 microM ) significantly increase tyrosine phosphorylation of [beta-catenin] , *induce* , uPAR , and cyclin D1 expression and enhance colon cancer cell proliferation and invasiveness . Positive_regulation CTNNB1 TF 17912456 1803858 differentially *regulated* E-cadherin and [beta-catenin] in these cells . Positive_regulation CTNNB1 TGM2 18405667 1899562 Extracellular *activates* [beta-catenin] signaling in calcifying vascular smooth muscle cells . Positive_regulation CTNNB1 TNF 10321728 612339 Mutant HOS which lacks the F-box blocked *induced* degradation of IkappaB as well as GSK3beta mediated degradation of [beta-catenin] . Positive_regulation CTNNB1 TNF 11950839 953617 A small molecule inhibitor of NF-kappaB dependent cytokine expression was discovered that blocked *induced* IkappaB(alpha) degradation in MM6 cells but not the degradation of [beta-catenin] in Jurkat cells . Positive_regulation CTNNB1 TNF 18511911 1922448 These results suggest that macrophage derived *promotes* [Wnt/beta-catenin] signalling through inhibition of GSK3beta , which may contribute to tumour development in the gastric mucosa . Positive_regulation CTNNB1 TP63 17297296 1698906 However , is also *involved* in RNA processing and activation of [beta-catenin] signaling . Positive_regulation CTNNB1 WNT7A 15705594 1402716 In NSCLC cells , and Fzd-9 induced both cadherin and Sprouty-4 expression and *stimulated* the JNK pathway , but not [beta-catenin/T] cell factor activity . Positive_regulation CTNNB1 WNT7A 15802269 1410460 *induced* the accumulation of [beta-catenin] and the activation of Rac and beta-catenin , and Rac synergistically induced the transcription of MMP-12 . Positive_regulation CTNNB1 WNT7A 18567805 1929744 binding to Fzd5 was shown to *activate* [beta-catenin/canonical] Wnt signaling and increase cellular proliferation . Positive_regulation CTNNBL1 EPHB2 12672049 1076368 These results demonstrate that [HP-NAP] activates neutrophils through a PTX-sensitive pathway and that and p38-MAPK are *involved* in many neutrophil functions stimulated by HP-NAP . Positive_regulation CTNND1 AXIN2 21098636 2355147 For example , in common with ß-catenin , exogenous expression of destruction complex components , such as GSK3ß and , *promotes* degradation of [p120-catenin] . Positive_regulation CTNND1 CAPN8 11511102 848846 In contrast , the cleavage of paxillin and [p130cas] in apoptotic L929 cells was *blocked* by inhibitors , which also reduced the death rate by 23 to 44 % . Positive_regulation CTNND1 CAPN8 17196166 1680429 Ischemia promotes *mediated* degradation of [p120-catenin] in SH-SY5Y cells . Positive_regulation CTNND1 CAPN8 17196166 1680443 This is the first report of the *mediated* degradation of [p120-catenin] and an association between the level of dephosphorylated p120-catenin and cell aggregation in ischemic neuronal cells . Positive_regulation CTNND1 CAPN8 21571907 2458923 Cyclic stretch induces alveolar epithelial barrier dysfunction via *mediated* degradation of [p120-catenin] . Positive_regulation CTNND1 CCND1 24979278 2947660 Thus , full activation of promoter activity *requires* ß-catenin activation of TCF-lef and stabilization of specific [p120 catenin] isoforms to relieve the repression of KAISO . Positive_regulation CTNND1 EDN2 10402223 628915 *stimulates* tyrosine phosphorylation of p125FAK and [p130Cas] in rat cerebral cortex . Positive_regulation CTNND1 EPHB2 23109808 2695311 EGF *activated* FAK ( Y397 ) and [p130cas] ( Y410 ) phosphorylation , while Fn activated general phosphorylation . Positive_regulation CTNND1 ITGB2 8631823 357172 Phosphorylation of [p130cas] was *dependent* on binding of to its ligand , ICAM-1 , as demonstrated by the use of anti-ICAM-1 antibodies . Positive_regulation CTNND1 SNCAIP 11056155 809679 *stimulated* tyrosine phosphorylation of [Cas] , which was inhibited by the G ( i ) inactivator pertussis toxin but not by the Rho inactivator C3 exoenzyme or the Rho kinase inhibitor Y-27632 . Positive_regulation CTNND1 SNCAIP 11056155 809680 Furthermore , upon HUVEC *stimulation* with , Crk , through its SH2 domain , interacted with tyrosine phosphorylated [Cas] , and the Cas-Crk complex translocated to the cell periphery ( membrane ruffles ) , through mediation of G ( i ) ( Fyn ) but not Rho . Positive_regulation CTR9 ALOX5 1650153 162974 Taken together , our studies indicate that [PAF] can significantly augment lung NK cell activity and that this effect is *dependent* on PKC , <5-lipoxygenase> , and extracellular calcium . Positive_regulation CTR9 ALOX5 3152458 104195 This suggests that <5-lipoxygenase> *dependent* mediators and [PAF] are involved in allergic contact dermatitis and that these mediators play only a minor role in irritant dermatitis . Positive_regulation CTR9 ALOX5 6089913 41331 The specific <5-lipoxygenase> inhibitor , 6,8-de-epoxy-6,9- ( phenylimino ) delta 6,8-prostaglandin I1 ( U-60257 ) , *inhibits* [PAF-acether] , but not leukotriene B4-mediated chemotaxis . Positive_regulation CTR9 ALOX5 8415804 234042 Although the early pulmonary vascular response ( < 10 min ) to PAF is dependent on cyclooxygenase products , the sustained response ( after 10 min ) can not be explained by either <5-lipoxygenase> or cyclooxygenase products but may be *mediated* directly by [PAF] receptors . Positive_regulation CTR9 ANGPT1 16617006 1624484 *mediated* endothelial [PAF] synthesis requires the activation of the p38 and p42/44 MAPKs , PI3K intracellular signalling pathways , and a secreted phospholipase A(2) ( sPLA ( 2 ) -V ) . Positive_regulation CTR9 CHI3L1 8245706 236927 On the other hand , the release of [platelet activating factor (PAF)] induced by opsonized particles was *enhanced* only by and not by CGP41-251 and CGP44-800 . Positive_regulation CTR9 EDN2 2051719 161788 In addition , induced a significant *increase* in the production of [PAF] by isolated glomeruli ( Basal , 81 +/- 10 pg/mg protein ; endothelin , 10 ( -7 ) M , 140 +/- 18 pg/mg protein ) . Positive_regulation CTR9 EDN2 8898708 393081 *stimulates* phosphoinositide hydrolysis and [PAF] synthesis in brain microvessels . Positive_regulation CTR9 HBEGF 17322418 1747797 Increased alkaline phosphatase ( AP ) activity after PAF treatment in AP-HB-EGF fusion construct transfected SMCs indicated that [PAF] *induced* the release of within 1 min. Gelatin zymography data showed that PAF stimulated MMP-2 activity and MMP-9 activity within 1 min . Positive_regulation CTR9 IL1B 10447739 577415 We conclude that CRH and [PAF] can *induce* the expression of , but this is not obligatory for increased PGE2 release , and the effect of these stimuli on COX-2 expression is a direct , IL-1beta independent effect . Positive_regulation CTR9 IL1B 1519663 196910 Stimulation of isolated mouse alveolar macrophages with recombinant murine or IL-1 alpha *resulted* in rapid , dose dependent , and cell concentration dependent increases in [PAF] secretion . Positive_regulation CTR9 IL1B 16807360 1612752 In circular muscle , exogenous [PAF] *induced* sequential formation of IL-6 , H ( 2 ) O ( 2 ) , , and PAF . Positive_regulation CTR9 IL1B 16829183 1591452 Both TNF-alpha and induced HUVEC platelet activating factor (PAF) production and [PAF] was *required* for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine ) . Positive_regulation CTR9 IL1B 7882558 298860 and IL-6 *stimulate* the production of [platelet activating factor (PAF)] by cultured rabbit synovial cells . Positive_regulation CTR9 IL1B 8080039 270820 and tumor necrosis factor-alpha *induce* [PAF] production by endothelium , and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist . Positive_regulation CTR9 ITGB2 7902855 245058 Ligation of was not *sufficient* for [PAF] synthesis suggesting that an additional receptor was involved . Positive_regulation CTR9 LBP 7541418 310466 Moreover , LeuM3 , 28C5 , and 18E12 mAbs that were themselves unable to stimulate the synthesis of PAF blocked [PAF] synthesis *initiated* by complex . Positive_regulation CTR9 LBP 7541418 310471 was *required* for synthesis of [PAF] by MO . Positive_regulation CTR9 MAP2K6 10606930 655850 The results showed that TNF alpha , IL-1 alpha and [PAF] *induced* serine phosphorylation of MKK3 and , and p38 MAP kinase activation in BECs . Positive_regulation CTR9 MUC16 9620929 510764 In rat tracheas studied by in situ hybridization , [PAF] *induced* MUC5 gene expression in epithelial cells that stained for mucosubstances . Positive_regulation CTR9 PLAT 1521562 196953 Using a perfused rat hindleg system , release of from endothelial cells could be *induced* by [platelet activating factor (PAF)] , bradykinin , substance P , thrombin , carbachol and A23187 , while this release was inhibited by mepacrine and by nor-dihydroguaiaretic acid . Positive_regulation CTR9 TGM2 7679111 211196 The finding that competitive inhibitors of significantly *inhibited* [C-PAF] release , enhancement of MC540 staining , and externalization of phosphatidylserine , strongly suggest a role for this enzyme in the enhancement of phospholipid transbilayer movement . Positive_regulation CTR9 TNF 10409262 629978 Both and interleukin-1 modestly *increased* plasma [PAF-AH] activity and mRNA levels in liver and spleen , suggesting that they may partly mediate the effect of LPS on PAF-AH . Positive_regulation CTR9 TNF 10435033 634215 ( 4 ) the synthesis of [PAF] *induced* by . Positive_regulation CTR9 TNF 11080081 749567 *increased* the production of [PAF] and NO . Positive_regulation CTR9 TNF 12428690 1014871 Synthesis of [PAF] was not *inducible* by in murine F10-M3 melanoma cells . Positive_regulation CTR9 TNF 15702351 1382766 Finally , up to 2 mug/ml , [PAF] did not *induce* the production of pro-inflammatory cytokines such as IL-6 , IL-8 , and . Positive_regulation CTR9 TNF 1668105 176688 [PAF] *induced* maximal synthesis 2-3 hr after monocyte stimulation as assessed by dot blotting of cell associated TNF alpha using polyclonal anti-TNF antibody . Positive_regulation CTR9 TNF 16829183 1591451 Both and IL-1beta induced HUVEC platelet activating factor (PAF) production and [PAF] was *required* for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine ) . Positive_regulation CTR9 TNF 18180165 1863037 *induces* [platelet activating factor (PAF)] synthesis in many inflammatory cells . Positive_regulation CTR9 TNF 18180165 1863042 We found that , although both cultures synthesized PAF at a similar basal rate , *induced* [PAF] synthesis in adipocytes was 7-fold higher than in preadipocytes . Positive_regulation CTR9 TNF 18180165 1863047 Wortmannin enhanced *dependent* [PAF] synthesis in adipocytes but not in preadipocytes , indicating the negative control by PI3K in mature cells . Positive_regulation CTR9 TNF 20016469 2204613 , which is assumed to mediate the interaction between mesangial cells and podocytes , also *induces* the expression of [platelet activating factor (PAF)] . Positive_regulation CTR9 TNF 20423922 2437237 In rats , increased hydraulic conductivity 2.5-fold over baseline and [PAF] *increased* it 5-fold ; Positive_regulation CTR9 TNF 2137857 128812 The peptide HDMNKVLDL ( antiflammin-2 ) inhibits the synthesis of [platelet activating factor (PAF)] *induced* by or phagocytosis in rat macrophages and human neutrophils , and by thrombin in vascular endothelial cells . Positive_regulation CTR9 TNF 2266661 147300 Inhibitors of PAF synthesis , such as plasma alpha 1-proteinase inhibitor and an anti-inflammatory peptide , blocked changes induced by TNF , PAF receptor antagonists inhibited changes *induced* by [PAF] and also by . Positive_regulation CTR9 TNF 2801951 119977 Since *stimulates* [PAF] synthesis in vitro , we tested the hypothesis that PAF mediates TNF induced lung injury in vivo using specific PAF receptor antagonists . Positive_regulation CTR9 TNF 3049910 99307 and IL-1 *stimulate* the synthesis and release of [platelet activating factor (PAF)] by neutrophils and vascular endothelial cells . Positive_regulation CTR9 TNF 3049910 99316 Low concentrations of this antiproteinase and of human plasma alpha 1-antichymotrypsin inhibited *induced* [PAF] synthesis in neutrophils , macrophages , and vascular endothelial cells . Positive_regulation CTR9 TNF 3119758 80236 Synthesis of [PAF] in *response* to was also detected in rat polymorphonuclear neutrophils , but not in human tumor cells and dermal fibroblasts . Positive_regulation CTR9 TNF 3261295 95988 About 30 % of [PAF] produced in *response* to either or IL-1 is released into the medium , whereas approximately 70 % remains cell associated . Positive_regulation CTR9 TNF 3261295 96007 Experiments with labeled precursors show that [PAF] is synthesized de novo in *response* to . Positive_regulation CTR9 TNF 3261295 96017 This suggests that [PAF] is synthesized by the same pathway in *response* to or IL-1 . Positive_regulation CTR9 TNF 3366898 93069 In the present study , we have shown that ( a ) *caused* [PAF] production in bowel tissue ; Positive_regulation CTR9 TNF 7516414 257606 These results suggest that the angiogenic effect of is , at least in part , *mediated* by [PAF] synthesized from monocytes and/or endothelial cells infiltrating the Matrigel plug . Positive_regulation CTR9 TNF 7681399 214258 In conclusion , the *enhancement* of [PAF] responses by , associated with functional characteristics of differentiation in Mono Mac 6 cells , may represent a specific mechanism of cooperative interaction between PAF and TNF in inflammation , sepsis , immunoregulation and atherogenesis . Positive_regulation CTR9 TNF 7821968 285553 We have shown previously that endotoxin , tumour necrosis factor (TNF) and platelet activating factor (PAF) are important in the pathogenesis of bowel injury , and that endotoxin and *induce* [PAF] formation in bowel tissue . Positive_regulation CTR9 TNF 7882905 289170 Because the release of [PAF] is *stimulated* by , this study was designed to measure the effects of polyI : C on TNF induced lung inflammation and injury . Positive_regulation CTR9 TNF 8080039 270819 Interleukin-1 beta and *induce* [PAF] production by endothelium , and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist . Positive_regulation CTR9 TNF 9394802 468195 These data suggest that [PAF] , which is released immediately or shortly after LPS injection , *induces* the expression of through the activation of NF-kappa B . Positive_regulation CTRL CAPN8 8158145 253476 The [chymotrypsinlike] activity ( cleavage after hydrophobic amino acids ) and the caseinolytic activity ( degradation of beta-casein ) of MPC were strongly *inhibited* by inhibitors 1 and 2 ( IC50 values in the low micromolar range ) . Positive_regulation CTSA EPHB2 22103431 2534871 Inhibition of activation using either PD98059 [ 2- ( 2-amino-3-methoxyphenyl ) -4H-1-benzopyran-4-one ] or U0126 ( 1,4-diamino-2,3-dicyano-1,4-bis [ 2-aminophenylthio ] butadiene ) had no impact on Aß production , and knockdown of endogenous GCS using small interfering RNA *reduced* cellular [GSL] levels without suppressing Aß production or pERK formation . Positive_regulation CTSB CAPN8 9751144 533504 These observations indicate that *induced* [cathepsin B] release is crucial for the development of the ischaemic neuronal death , and that a specific inhibitor of cathepsin B is of potential therapeutic utility in ischaemic injuries to the human CNS . Positive_regulation CTSB EPHB2 9390997 467669 Moreover , PD 98059 inhibited phorbol ester stimulation of [APPs] production and *activation* of in both human embryonic kidney cells and cortical neurons . Positive_regulation CTSB F3 7635444 317195 Interleukin-1 also upregulates expression and processing of beta-amyloid precursor proteins ( [beta-APPs] ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation CTSB IL1B 12726991 1086346 The released form is stable at neutral and alkaline pH and , in both cell types , intracellular and extracellular [cathepsin B] activities are *increased* by and parathyroid hormone (PTH) . Positive_regulation CTSB IL1B 12726991 1086348 Results show that in normal conditions and in the *presence* of , [cathepsin B] is involved in the activation of PA . Positive_regulation CTSB IL1B 18464888 1910139 Furthermore , pre-treatment with IL-4 ( 10 ng/ml ) suppressed both MMP-13 and [cathepsin B] *induction* by mechanical stress , as well as CTS induced expression . Positive_regulation CTSB IL1B 19139407 2025654 Uptake of microparticles induced lysosomal damage , whereas particle mediated enhancement of secretion *required* phagosomal acidification and the lysosomal cysteine protease [cathepsin B] , suggesting a role for lysosomal damage in inflammasome activation . Positive_regulation CTSB IL1B 8645703 363328 ( 1-100 U/ml ) and PTH ( 10 ( -9 ) M-10 ( -6 ) M ) significantly *stimulated* [cathepsin B] activity in cell extracts and in conditioned media . Positive_regulation CTSB IL1B 9068283 419019 Chondrocyte monolayers were used to determine [cathepsin-B] expression in *response* to . Positive_regulation CTSB IL1B 9366717 463333 Expression of and TNF-alpha mRNA could not be *induced* by trypsin , chymotrypsin , or [cathepsin-B] . Positive_regulation CTSB PLAU 11815600 928873 Pretreatment with cycloheximide did not suppress the exocytosis of [cathepsin B] or the *activation* of . Positive_regulation CTSB PLAU 1847936 153531 This increase in [cathepsin B-like] activity is also *restored* by exogenous . Positive_regulation CTSB STK39 1341708 209329 On the other hand , the activation of [cathepsin B] was *inhibited* by neomycin B ( phospholipase C inhibitor ) and various inhibitors . Positive_regulation CTSB TNF 11381085 820624 In WEHI-S fibrosarcoma cells , induced an *increase* in cytosolic [cathepsin B] activity followed by death with apoptotic features . Positive_regulation CTSB TNF 12185082 992635 Furthermore , *induced* [cathepsin B-dependent] AA release could be dissociated from the cathepsin B-independent cell death in MCF-7S1 cells , whereas both events required cathepsin B activity in other cell lines tested . Positive_regulation CTSB TNFSF10 17136492 1677997 Our data show that or hypoxia independently *triggered* activation of [cathepsin B] and D leading to apoptosis through Bid and Bax , and suggest that hypoxic tissue regions provide a selective environment for highly apoptosis-resistant clonal cells . Positive_regulation CTSC FAS 16547231 1537673 The apoptotic signaling pathway bypassed and TNFRs , and *required* the activity of [cathepsin C] , a protease which performs the proteolytic maturation of granzyme (Gr) A and GrB proenzymes within the cytolytic granules . Positive_regulation CTSC PLAU 8055919 267892 *Activation* of thrombin inactivated single-chain by [dipeptidyl peptidase I] ( cathepsin C ) . Positive_regulation CTSC TNF 7994374 283076 [Hb+PLs] *induced* smaller increases of and IL-6 , and a decrease in the levels of IL-1 and GM-CSF . Positive_regulation CTSD ANGPT1 12811821 1102912 Expression of alpha-smooth muscle ( SM ) actin , apparent in the contractile phenotype , was decreased by FN. Expressions of matrix Gla and osteopontin , apparent in the synthetic phenotype , were increased by FN . Ang II measured by radioimmunoassay ( RIA ) was significantly increased in human VSMC by FN. Expression of mRNAs for Ang II-generating proteases cathepsin D , cathepsin G , ACE , and chymase was increased by FN. Expressions of [cathepsin D] and cathepsin G proteins were also *increased* by FN. activity , which was inhibited by an aspartyl protease inhibitor pepstatin A , was readily detected in the conditioned medium from human VSMC . Positive_regulation CTSD CAPN8 16021180 1498116 In contrast , drug treatment caused EndoG translocation , *activation* of , and both the synthesis and activation of [cathepsin D] . Positive_regulation CTSD PLAU 1900515 153995 In contrast , no significant *activation* of by [cathepsin D] was observed . Positive_regulation CTSD TGM2 21960143 2718853 Binding of to CTSD *resulted* in the depletion of [CTSD] via cross linking in vitro as well as in MEFs , leading to decreased levels of apoptosis . Positive_regulation CTSD TNF 14739942 1235040 Here , we show that *induced* [CTSD] activation depends on functional acid sphingomyelinase (A-SMase) expression . Positive_regulation CTSD TNF 14739942 1235041 Ectopic expression of [CTSD] in CTSD-deficient fibroblasts results in an enhanced *mediated* apoptotic response . Positive_regulation CTSG ANGPT1 12811821 1102914 Expression of alpha-smooth muscle ( SM ) actin , apparent in the contractile phenotype , was decreased by FN. Expressions of matrix Gla and osteopontin , apparent in the synthetic phenotype , were increased by FN . Ang II measured by radioimmunoassay ( RIA ) was significantly increased in human VSMC by FN. Expression of mRNAs for Ang II-generating proteases cathepsin D , cathepsin G , ACE , and chymase was increased by FN. Expressions of cathepsin D and [cathepsin G] proteins were also *increased* by FN. activity , which was inhibited by an aspartyl protease inhibitor pepstatin A , was readily detected in the conditioned medium from human VSMC . Positive_regulation CTSG ITGB2 8920993 396713 However , inflammatory stimuli , including formyl peptide or phorbol ester , or engagement with its ligands fibrinogen , factor X or serum opsonized zymosan , *triggered* monocyte degranulation and [cathepsin G] activation of factor X . Positive_regulation CTSG SELL 21860019 2490885 Using knockout mice and blocking antibodies , we found that mucin triggered [cathepsin G] release *requires* and PSGL-1 on neutrophils , P-selectin on platelets , and Src family kinases in both cell types . Positive_regulation CTSG TNF 11722574 884087 The reactive centre loop sequence is essential for this function and *induced* [cathepsin G] is a candidate target . Positive_regulation CTSG TNF 7499869 336090 In this study , we describe expression of neutrophil cell surface bound [cathepsin G] in *response* to and platelet activating factor (PAF) under conditions in which minimal free release of cathepsin G is detected . Positive_regulation CTSG TNF 7499869 336105 and PAF alone *induced* modest ( two- to threefold ) increases in cell surface bound [cathepsin G] , but exhibited a marked dose- and time dependent priming effect for subsequent chemoattractant induced responses ( up to 15- to 25-fold increases in cell surface expression ) . Positive_regulation CTSK CLU 22569264 2596969 *increases* the stability of [cathepsin K] in dilute solution and in the presence of high protein concentration . Positive_regulation CTSK IL1B 19834062 2154777 Furthermore , the expression of [cathepsin K] , a marker for osteoclast activity , *induced* by was dependent on TLR4 . Positive_regulation CTSL CST6 3319612 81803 The [cathepsin-L-like] activity is *inhibited* by the thiol-protease inhibitors , E-64 , , leupeptin and mercurial compounds . Positive_regulation CTSL FOXO1 20088826 2218954 Using C2C12 mouse myoblasts overexpressing a constitutively active form of FOXO1 , we showed that *induces* [Ctsl] expression . Positive_regulation CTSL FOXO1 20088826 2218955 The luciferase reporter analysis revealed that the mouse [Ctsl] and human CTSL1 promoters are *activated* by , which is abolished by mutations in the consensus FOXO1 binding sites . Positive_regulation CTSL PLAU 1551416 184056 As determined by N-terminal amino acid sequence analysis , *activation* of by [cathepsin L] is achieved by cleavage of the Lys158-Ile159 peptide bond , a common activation site of serine proteases such as plasmin and kallikrein . Positive_regulation CTSL TNF 16918298 1602619 Human *stimulated* not only the production of the 32-kDa [cathepsin L] , but also its secretion . Positive_regulation CTSS CAPN8 20171158 2228722 The main event of this cascade is *mediated* lysosomal rupture and the resultant release of lysosomal [cathepsins] into the cytoplasm . Positive_regulation CTSS CST6 15161240 1252823 The [cathepsins] and MTGase activities in WSP , SSP , and MP solutions decreased , but the recombinant activity *increased* during setting at 45 degrees C . Positive_regulation CTSS EPHB2 18701486 1950460 Importantly , K-ras and erbb2 elicit a similar *mediated* activation of cysteine [cathepsins] , cathepsin dependent down-regulation of LAMPs , and increased drug sensitivity in human colon and breast carcinoma cells , respectively . Positive_regulation CTSS TNF 10362800 620151 *induced* [cathepsin S] , MMP-1 , -3 , and -9 mRNA expression in a dose dependent manner : the maximal effect was observed at a concentration of 10 ng/ml , with appreciable increases observed at concentrations of 0.1 to 1.0 ng/ml . Positive_regulation CTSS TNF 19409515 2128180 Based on the use of pharmacological caspase inhibitors , the *induced* caspase dependent apoptotic cell death in both cell lines , which was accompanied by lysosomal destabilization and the release of [cathepsins] in the cytosol . Positive_regulation CTSS TNFSF10 17136492 1677996 Hypoxia or *induced* activation of [cathepsins] ( B , D and L ) , caspases ( -3 and -9 ) , Bid cleavage , release of Bax and cytochrome c , and DNA fragmentation were blocked independently by zVAD-fmk , CA074Me or pepstatin A , consistent with the involvement of lysosomal cathepsin B and D in cell death . Positive_regulation CTTN CCND1 16536875 1549472 is *involved* in cell cycle regulation and the F-actin binding protein [cortactin] in cytoskeletal dynamics and cell migration . Positive_regulation CTTN EPHB2 15169891 1253633 phosphorylation and a mimicking S405,418D double mutation *enhanced* [cortactin] binding and activation of N-WASP . Positive_regulation CTTN GPR115 16416022 1597556 In this report , we describe that S1P stimulated [cortactin] translocation to the cell periphery to form lamellipodia is specifically *mediated* by the endothelial S1P1 , and is regulated by G ( i ) -mediated Akt dependent S1P1 receptor phosphorylation and Cdc42/Rac activation pathways . Positive_regulation CTTN GPR132 16416022 1597545 In this report , we describe that S1P stimulated [cortactin] translocation to the cell periphery to form lamellipodia is specifically *mediated* by the endothelial S1P1 , and is regulated by G ( i ) -mediated Akt dependent S1P1 receptor phosphorylation and Cdc42/Rac activation pathways . Positive_regulation CTTN GPR87 16416022 1597626 In this report , we describe that S1P stimulated [cortactin] translocation to the cell periphery to form lamellipodia is specifically *mediated* by the endothelial S1P1 , and is regulated by G ( i ) -mediated Akt dependent S1P1 receptor phosphorylation and Cdc42/Rac activation pathways . Positive_regulation CTTN SPHK1 24084691 2888658 Reduced apoptosis , increased EOC migration , and [cortactin] upregulation by FHL2 siRNA were *prevented* by CAY10621 , the inhibitor , and the sphingosine-1-phosphate receptor-1/-3 antagonist VPC23019 . Positive_regulation CUL1 EPHB2 11412047 828329 [SCF] *induced* a rapid and transient activation of and p38 in a dose dependent manner . Positive_regulation CUL1 EPHB2 16436136 1516428 The induction of RANTES by SCF or TNF-alpha was mediated by and NF-kappaB , respectively , and [SCF] induced MIP-1beta release was *mediated* by ERK . Positive_regulation CUL1 FAS 17695539 1782186 High expression of [c-kit/SCF] ( 2+ , 3+ ) was *detected* in 28/45 cases of EFT ( 62.2 % ) , whereas and IGF-IR were observed in 16/45 ( 37.7 % ) and 9/45 ( 20 % ) , respectively . Positive_regulation CUL1 IL1B 11934803 927864 5. Budesonide inhibited *induced* [SCF] mRNA expression ( -68 % ) at 2 .5 h and even more so at 10 h ( -192 % ) Positive_regulation CUL1 IL1B 15962114 1423090 Transfection experiments with the SCF promoter including intron1 also confirm this increase and decrease of SCF expression by IL-1beta and glucocorticoids , and the potentiation by glucocorticoids of the *induced* [SCF] expression . Positive_regulation CUL1 IL1B 16407046 1513298 We investigated whether HDSMCs are capable of expressing and releasing MCP-1 , IL-6 and [SCF] in *response* to IL-4 , IL-13 , and tumor necrosis factor-alpha . Positive_regulation CUL1 IL1B 16612597 1665859 The effect of exogenous IFNgamma on AML blast proliferation was dependent on the local cytokine network and IFNgamma ( 1 ) inhibited proliferation in the *presence* of exogenous , GM-CSF , G-CSF and [SCF] ; Positive_regulation CUL1 IL1B 7544739 318386 Stimulation with only modestly *increased* SCF mRNA levels , soluble [SCF] production at 24 hours , and membrane bound SCF . Positive_regulation CUL1 JAG1 10342559 616492 However , in the presence of [SCF] alone , *increased* erythroid colony formation twofold . Positive_regulation CUL1 TNF 10067879 594037 Activin , TGF beta , TGF alpha , and *had* no effect on [SCF] gene expression in vitro . Positive_regulation CUL1 TNF 16407046 1513297 We investigated whether HDSMCs are capable of expressing and releasing MCP-1 , IL-6 and [SCF] in *response* to IL-4 , IL-13 , IL-1beta and . Positive_regulation CUL1 TNF 16436136 1516388 Either [SCF] or TNF-alpha could *induce* release from HMC-1 cells of interleukin (IL)-8 , monocyte chemoattractant protein (MCP)-1 , regulated upon activation normal T-cell expressed and secreted ( RANTES ) , and I-309 , while SCF and induced release of macrophage inflammatory protein (MIP)-1beta and interferon-gamma-inducible protein-10 (IP-10) , respectively . Positive_regulation CUL1 TNF 18549896 1923757 In vitro studies using primary mouse hepatocytes show that [SCF] is *induced* by ; Positive_regulation CUL1 TNF 7544739 318389 Similarly , a sustained increase in soluble [SCF] production was *detected* during 1 to 5 days of hydrocortisone exposure ( 0.27 +/- 0.03 to 1.10 +/- 0.08 ng/mL per 10 ( 6 ) cells ) , while stimulation modestly increased the production of soluble SCF in 24-hour cultures only . Positive_regulation CUL1 TNF 9307079 454439 We have shown that the [SCF] expression can be induced in vitro by co-culture with mast cells and this induction was *dependent* on the release of . Positive_regulation CUL1 TNF 9637535 513875 [SCF] was constitutively produced from fibroblasts in its transmembrane form and could be *induced* by . Positive_regulation CUL1 TNF 9759885 536636 Coligation of SCFR augmented Fc epsilonRI mediated activation of MAP kinases , especially JNK activation , and SCF augmented Fc epsilonRI mediated TNF-alpha production in MC/9 cells , although [SCF] alone did not *induce* production . Positive_regulation CUL5 IL1B 11403206 824944 At 4 h ICAM-1 and E-selectin , but not [VACM-1] , were *stimulated* by both and TNF-alpha . Positive_regulation CUL5 TNF 11403206 824943 At 4 h ICAM-1 and E-selectin , but not [VACM-1] , were *stimulated* by both IL-1beta and . Positive_regulation CUX2 IFI27 18223201 1864148 Furthermore , [Cux2] overexpression *induces* high levels of Neurod and ( Kip1 ) . Positive_regulation CWC15 TNF 22170509 2563288 The [CWC] *induced* the production about 1.3 times higher than that of the commercially available ß-1,3/1,6-glucan from baker 's yeast cells . Positive_regulation CWC22 TNF 22170509 2563289 The [CWC] *induced* the production about 1.3 times higher than that of the commercially available ß-1,3/1,6-glucan from baker 's yeast cells . Positive_regulation CWC25 TNF 22170509 2563287 The [CWC] *induced* the production about 1.3 times higher than that of the commercially available ß-1,3/1,6-glucan from baker 's yeast cells . Positive_regulation CWC27 TNF 22170509 2563282 The [CWC] *induced* the production about 1.3 times higher than that of the commercially available ß-1,3/1,6-glucan from baker 's yeast cells . Positive_regulation CX3CL1 CTGF 16408113 1513390 The present studies investigate the regulatory *role* of in the production of [fractalkine] , monocyte chemoattractant protein-1 ( MCP-1 ) , and RANTES ( regulated upon activation , normal T cell expressed and secreted ) in cultured mesangial cells of rats , and the modulatory effects of lipoxin A ( 4 ) ( LXA ( 4 ) ) on actions of CTGF . Positive_regulation CX3CL1 CTGF 16408113 1513468 *enhanced* the mRNA expression and protein release of [fractalkine] , MCP-1 , and RANTES , the expression of phospho ( P ) -p42/44 mitogen activated protein kinase (MAPK) , P-phosphoinositide 3-kinase (PI3-K) , P-Akt , and activity of nuclear factor-kappaB (NF-kappaB) in mesangial cells . Positive_regulation CX3CL1 CTGF 16408113 1513546 In conclusion , these results demonstrate that *induces* production of [fractalkine] , MCP-1 , and RANTES via the p42/44 MAPK- , PI3-K/Akt- , and NF-kappaB dependent signal pathway , and LXA ( 4 ) downregulates the above effects of CTGF on rat mesangial cells . Positive_regulation CX3CL1 EPHB2 23147224 2722948 [CX3CL1] release was *suppressed* by specific inhibitors of , MMP , and ADAM , and ERK was associated with CX3CL1 transcription . Positive_regulation CX3CL1 IL1B 10415068 631202 Molecular analyses of the chemokine fractalkine and its receptor CX3C-R1 in the rat brain have revealed a striking polarization : [fractalkine] is expressed constitutively in neurons and is *up-regulated* by TNF-alpha and in astrocytes . Positive_regulation CX3CL1 IL1B 16954166 1615689 In addition , p-cresol decreased *induced* expression of membrane bound and soluble forms of [fractalkine] and impaired the membrane expression of JAM-A . Positive_regulation CX3CL1 MMP28 23147224 2722925 [CX3CL1] release was *suppressed* by specific inhibitors of ERK , , and ADAM , and ERK was associated with CX3CL1 transcription . Positive_regulation CX3CL1 MMP7 23147224 2722963 [CX3CL1] release was *suppressed* by specific inhibitors of ERK , , and ADAM , and ERK was associated with CX3CL1 transcription . Positive_regulation CX3CL1 TNF 10415068 631201 Molecular analyses of the chemokine fractalkine and its receptor CX3C-R1 in the rat brain have revealed a striking polarization : [fractalkine] is expressed constitutively in neurons and is *up-regulated* by and IL-1beta in astrocytes . Positive_regulation CX3CL1 TNF 10652441 663186 [Fractalkine] modulates secretion and neurotoxicity *induced* by microglial activation . Positive_regulation CX3CL1 TNF 11311510 804960 We found that and interferon-gamma (IFN-gamma) synergistically *enhance* the expression of [fractalkine] . Positive_regulation CX3CL1 TNF 11525637 853010 sIL-6R markedly inhibited HUVEC [fractalkine/CX3CL1] expression *induced* by interleukin (IL)-1alpha , , or interferon (IFN)-gamma . Positive_regulation CX3CL1 TNF 11698246 877785 This resulted in a marked inhibition of *induced* expression of mRNA and protein for the immunoglobulin molecules intracellular adhesion molecule-1 and vascular cell adhesion molecule-1 and the chemokines growth related oncogene-alpha , monocyte chemoattractant protein-1 , interleukin-8 , or [fractalkine] in MC . Positive_regulation CX3CL1 TNF 11777952 899777 [Fractalkine] is expressed by smooth muscle cells in *response* to IFN-gamma and and is modulated by metalloproteinase activity . Positive_regulation CX3CL1 TNF 11777952 899781 Hence , during vascular inflammation , the synergistic *induction* of [fractalkine] by IFN-gamma and together with its metalloproteinase mediated cleavage may finely control the recruitment of monocytes to SMC within the blood vessel wall . Positive_regulation CX3CL1 TNF 12631113 1067587 *stimulates* [fractalkine] production by mesangial cells and regulates monocyte transmigration : down-regulation by cAMP . Positive_regulation CX3CL1 TNF 12631113 1067603 The incubation of MCs with MG132 , a NF-kappaB inhibitor , abolished *induced* degradation of inhibitory protein of NF-kappaB ( I-kappaB)alpha , nuclear translocation of NF-kappaB , and [fractalkine] expression , without affecting phospho-c-Jun levels . Positive_regulation CX3CL1 TNF 12631113 1067606 In contrast , curcumin , an activating protein (AP)-1 inhibitor , attenuated *stimulated* phospho-c-Jun levels and [fractalkine] expression without discernible effects on TNF-alpha induced degradation of I-kappaBalpha or NF-kappaB nuclear translocation . Positive_regulation CX3CL1 TNF 12631113 1067627 The present data indicate that activation of PKCzeta/iota , p42/44 MAPK , c-Jun/AP-1 , and p65/NF-kappaB are *involved* in TNF-alpha stimulated MC [fractalkine] expression , with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro . Positive_regulation CX3CL1 TNF 12642397 1069378 Inhibition by pentoxifylline of *stimulated* [fractalkine] production in vascular smooth muscle cells : evidence for mediation by NF-kappa B down-regulation . Positive_regulation CX3CL1 TNF 12642397 1069379 This study investigated signal transduction mechanisms by which *stimulated* [fractalkine] expression in cultured rat vascular smooth muscle cells ( VSMCs ) , and the modulatory effect of a haemorrheologic agent , pentoxifylline , on its production . Positive_regulation CX3CL1 TNF 12729461 1106703 activated nuclear factor kappaB (NF-kappaB) and *induced* [fractalkine] and CX3CR1 expression in a time dependent manner in rat aortic SMCs . Positive_regulation CX3CL1 TNF 12729461 1106717 Transient transfections with dominant negative ( dn ) inhibitory kappaB (IkappaB)-alpha , dnIkappaB-beta , dnIkappaB kinase ( IKK)-gamma , kinase-dead ( kd ) NF-kappaB inducing kinase (NIK) and kdIKK-beta , or pretreatment with wortmannin , Akt inhibitor , pyrrolidinecarbodithioc acid ammonium salt ( ` PDTC ' ) or MG-132 , significantly attenuated *induced* [fractalkine] and CX3CR1 expression . Positive_regulation CX3CL1 TNF 12729461 1106719 Pretreatment with pertussis toxin or neutralizing anti-CX3CR1 antibodies attenuated *induced* [fractalkine] expression , indicating that fractalkine autoregulation plays a role in TNF-alpha induced sustained fractalkine expression . Positive_regulation CX3CL1 TNF 12729461 1106720 Taken together , our results demonstrate that *induces* the expression of [fractalkine] and CX3CR1 in rat aortic SMCs and that this induction is mediated by NF-kappaB activation . Positive_regulation CX3CL1 TNF 14605272 1161856 *Up-regulation* of MC [CX3CL1/fractalkine] by , IL-1beta , PDGF-AB and bFGF is mediated , at least in part , via the nuclear factor-kappaB signalling pathway . Positive_regulation CX3CL1 TNF 15013759 1220692 and IL-4 *regulate* expression of [fractalkine] ( CX3CL1 ) as a membrane anchored proadhesive protein and soluble chemotactic peptide on human fibroblasts . Positive_regulation CX3CL1 TNF 15111313 1241125 *induces* [fractalkine] expression preferentially in arterial endothelial cells and mithramycin A suppresses TNF-alpha induced fractalkine expression . Positive_regulation CX3CL1 TNF 15111313 1241127 However , the potential mechanism and significance of *induced* [fractalkine] expression in vascular endothelial cells are poorly understood . Positive_regulation CX3CL1 TNF 15111313 1241128 Here we show that in primary cultured endothelial cells *induced* [fractalkine] mRNA expression is mediated mainly through phosphatidylinositol 3'-kinase activation and nuclear factor (NF)-kappaB mediated transcriptional activation , along with GC-rich DNA binding protein mediated transcription . Positive_regulation CX3CL1 TNF 15111313 1241131 Interestingly , GC-rich DNA binding protein inhibitors , mithramycin A and chromomycin A3 , strongly suppressed *induced* [fractalkine] mRNA expression , possibly through inhibition of transcriptional activities by NF-kappaB and Sp1 . Positive_regulation CX3CL1 TNF 15111313 1241133 In fact , direct inhibition of NF-kappaB and Sp1 bindings by decoy oligonucleotides suppressed *induced* [fractalkine] expression . Positive_regulation CX3CL1 TNF 15111313 1241136 Histologically , *induced* [fractalkine] expression was observed markedly in arterial and capillary endothelial cells , endocardium , and endothelium of intestinal villi , and slightly in venous endothelial cells , but not at all in lymphatic endothelial cells of intestine . Positive_regulation CX3CL1 TNF 15111313 1241137 Mithramycin A markedly suppressed *induced* [fractalkine] expression in vivo . Positive_regulation CX3CL1 TNF 15111313 1241138 These results indicate that *stimulated* [fractalkine] expression could act as part of arterial endothelial adhesion to leukocytes and monocytes during inflammation and atherosclerosis . Positive_regulation CX3CL1 TNF 16413026 1618806 Additionally , ALA inhibited *stimulated* [fractalkine] expression in cultured vascular smooth muscle cells ( VSMCs ) , a process which is mediated through the NF-kappaB pathway . Positive_regulation CX3CL1 TNF 16614140 1575048 Resveratrol suppresses *induced* [fractalkine] expression in endothelial cells . Positive_regulation CX3CL1 TNF 16614140 1575049 Resveratrol strongly suppressed *induced* [fractalkine] expression in endothelial cells through suppression of nuclear factor-kappaB and Sp1 activities . Positive_regulation CX3CL1 TNF 16614140 1575050 Immunohistochemical analysis revealed that resveratrol suppressed *induced* arterial endothelial [fractalkine] expression in heart , kidney , and intestine and decreased ED-1 positive cell infiltration in intestinal villi . Positive_regulation CX3CL1 TNF 18239149 1884615 and IFNgamma , mainly when combined , *stimulate* IFNgamma-inducible protein of 10 kDa (IP10) and [fractalkine] production evaluated by ELISA and TaqMan analyses . Positive_regulation CX3CL1 TNF 18296082 1924932 The pro-inflammatory cytokine *increased* expression of [fractalkine] by vSMC and vEC . Positive_regulation CX3CL1 TNF 19493461 2091470 Aspirin inhibits *stimulated* [fractalkine] expression in human umbilical vein endothelial cells . Positive_regulation CX3CL1 TNF 19493461 2091471 *stimulated* [fractalkine] expression is suppressed by aspirin in a dose dependent manner through the nuclear factor-kappa B p65 pathway . Positive_regulation CX3CL1 TNF 19910690 2162141 Epigallocatechin-3-O-gallate decreases *induced* [fractalkine] expression in endothelial cells by suppressing NF-kappaB . Positive_regulation CX3CL1 TNF 19910690 2162143 These results demonstrate that EGCG prevents *induced* vascular endothelial [fractalkine] expression . Positive_regulation CX3CL1 TNF 20231691 2237848 [CX3CL1/fractalkine] , a chemokine specific to monocytes and NK cells , is *induced* synergistically by and IFN-gamma in vascular endothelial cells . Positive_regulation CX3CL1 TNF 20231691 2237881 CX3CL1 expression is under control of posttranscriptional regulation , which is involved in the synergistic induction of [CX3CL1] in *response* to the combined stimulation with and IFN-gamma . Positive_regulation CX3CL1 TNF 20798528 2313725 Genistein suppression of *induced* [fractalkine] expression in endothelial cells . Positive_regulation CX3CL1 TNF 20798528 2313726 significantly *induced* [fractalkine] expression in endothelial cells . Positive_regulation CX3CL1 TNF 20798528 2313728 Genistein decreased *induced* [fractalkine] expression through suppression of Akt and p38 phosphorylation and NF-kappaB activities . Positive_regulation CX3CL1 TNF 22096344 2010006 Synergistic *induction* of [CX3CL1] by and IFN gamma in osteoblasts from rheumatoid arthritis : involvement of NF-kappa B and STAT-1 signaling pathways . Positive_regulation CX3CL1 TNF 22096344 2010008 Although or interferon ( IFN ) -? alone RA OB induced negligible CX3CL1 secretion , the combination of TNF-a and IFN-? *induced* dramatic increases in both soluble [CX3CL1] protein and mRNA transcripts . Positive_regulation CX3CR1 IL1B 12555203 1051622 Moreover , TNFalpha and significantly *increase* BOB/GPR15 , CCR2 , and [V28/CX3CR1] mRNA levels in both models . Positive_regulation CX3CR1 TNF 12555203 1051621 Moreover , and IL-1beta significantly *increase* BOB/GPR15 , CCR2 , and [V28/CX3CR1] mRNA levels in both models . Positive_regulation CX3CR1 TNF 12729461 1106708 activated nuclear factor kappaB (NF-kappaB) and *induced* fractalkine and [CX3CR1] expression in a time dependent manner in rat aortic SMCs . Positive_regulation CX3CR1 TNF 12729461 1106718 Transient transfections with dominant negative ( dn ) inhibitory kappaB (IkappaB)-alpha , dnIkappaB-beta , dnIkappaB kinase ( IKK)-gamma , kinase-dead ( kd ) NF-kappaB inducing kinase (NIK) and kdIKK-beta , or pretreatment with wortmannin , Akt inhibitor , pyrrolidinecarbodithioc acid ammonium salt ( ` PDTC ' ) or MG-132 , significantly attenuated *induced* fractalkine and [CX3CR1] expression . Positive_regulation CX3CR1 TNF 12729461 1106727 Taken together , our results demonstrate that *induces* the expression of fractalkine and [CX3CR1] in rat aortic SMCs and that this induction is mediated by NF-kappaB activation . Positive_regulation CX3CR1 TNF 17471309 1731987 In the in vitro culture experiments , IL-10 induced [CX3CR1] expression on the surface of monocytes , and *induced* membrane bound FKN as well as soluble FKN expression in synovial fibroblasts . Positive_regulation CX3CR1 TNF 20798528 2313729 Genistein also strongly suppressed *induced* expression of [CX3CR1] in monocytes . Positive_regulation CXADR EPHB2 14645111 1210254 Taken together , our data show that *activation* of PI3K and p38 MAPK but not of by the [CaR] promotes proliferation of H-500 cells as well as affords protection against apoptosis . Positive_regulation CXADR MAP2K6 21791114 2472506 We have previously reported that ( Cancer Res. 2003 May 1 ; 63 ( 9 ) : 2088-95 ) and TGF-ß ( Cancer Res. 2006 Feb 1 ; 66 ( 3 ) : 1648-57 ) signaling negatively *regulate* [coxsackie virus and adenovirus receptor] ( CAR ) cell-surface expression and adenovirus uptake . Positive_regulation CXADR TNF 18636168 1937260 To obtain a better understanding of *induced* molecular interactions between [CaR] and VDCC , confocal fluorescence measurements were performed on insulin producing beta-cells exposed to varying concentrations of TNF-alpha and the results are discussed in the light of increased colocalization correlation coefficient . Positive_regulation CXCL1 CTGF 24318513 2921430 Various experiments performed using human TM cells revealed that constitutively active RhoA ( RhoAV14 ) , TGF-ß2 , LPA , and significantly *increase* the levels and expression of [Fibroblast Specific] Serum Response Factor (SRF)ein-1 (FSP-1) , a-smooth muscle actin ( aSMA ) , collagen-1A1 and secretory total collagen , as determined by q-RT-PCR , immunofluorescence , immunoblot , flow cytometry and the Sircol assay . Positive_regulation CXCL1 EPHB2 15894298 1440060 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated kinase ( MEK ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL1 F2R 7482442 335399 These results suggest that catalytic activation of by thrombin *results* in GRO [alpha/MGSA] production , at least in part , via a pathway involving PKC in HUVEC . Positive_regulation CXCL1 IL1B 15774504 1397275 CXCL8 and [CXCL1] production by human astrocytes at both the RNA and protein levels could be *induced* by interleukin (IL)-1beta , while CXCL10 was induced by both and interferon-gamma . Positive_regulation CXCL1 IL1B 20032224 2205115 GTE ( 2.5-40 microg/ml ) inhibited *induced* MCP-1/CCL2 ( 10 ng/ml ) , RANTES/CCL5 , [GROalpha/CXCL1] and IL-8/CXCL8 production in human RA synovial fibroblasts ( P < 0.05 ) . Positive_regulation CXCL1 IL1B 20182449 2272429 IL-1alpha and *increased* mRNA production and protein secretion of the neutrophil chemotactic [CXCL1] , CXCL2 , and IL-8 in keratinocytes . Positive_regulation CXCL1 IL1B 8344798 226499 Reverse-transcription polymerase chain reaction was used to determine the steady-state mRNA expression of three forms of [MGSA/gro] , alpha , beta , and gamma , by cultured human RPE cells in the *presence* or absence of recombinant , TNF alpha , or TGF beta , or when serum starved cells were re-fed with medium containing serum . Positive_regulation CXCL1 IL1B 8344798 226500 however , *induced* secretion of [MGSA/gro] in a time dependent manner . Positive_regulation CXCL1 MAP2K6 15894298 1440066 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated protein/ERK kinase ( ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL1 PLAT 20724593 2323797 In the murine obstruction model , deficiency *reduced* renal GSK3ß phosphorylation and induction of PCNA and [FSP-1] . Positive_regulation CXCL1 RNF150 20648642 2292848 Using a panel of kinase inhibitors , we demonstrated that NOV action on CCL2 and [CXCL1] production *involved* a and a Rho/qROCK/p38/NF-kappaB pathway , respectively . Positive_regulation CXCL1 TLR7 24920846 2946690 Levels of *stimulated* [CXCL1] and CXCL2 but not CXCL10 or CCL5 mRNAs were selectively enhanced ( > 10-fold ) in stressed macrophages . Positive_regulation CXCL1 TNF 18198355 1883758 The [FSP27] transcript is inversely *regulated* by and insulin , consistent with an antilipolytic function . Positive_regulation CXCL1 TNF 18644347 1947744 As a result , *induced* expression of inflammatory cytokines , [CXCL1/KC] and CCL2/MCP-1 , was clearly inhibited by Celecoxib . Positive_regulation CXCL1 TNF 19091594 2031049 Interestingly , we observed that *induced* expression of IL-6 , [CXCL1] and granulocyte macrophage colony stimulating factor ( GM-CSF ) were significantly enhanced in TRAF6-deficient MEFs . Positive_regulation CXCL1 TNF 19541354 2142425 In cultured keratinocytes AE248 suppressed [CXCL1] production *induced* by . Positive_regulation CXCL1 TNF 20153843 2236130 In addition , *induced* expression of inflammatory cytokines , CCL2/MCP-1 and [CXCL1/KC] , was clearly inhibited by Licochalcone A but not reduced Licochalcone A . Positive_regulation CXCL1 TNF 22976954 2693597 The synergistic effect of and IL-17A on astrocytes *resulted* in enhanced secretion of [CXCL-1] , a neutrophil chemoattractant . Positive_regulation CXCL1 TNF 23831863 2839006 In cultured astrocytes , *induced* robust [CXCL1] expression via the activation of the c-jun N-terminal kinase . Positive_regulation CXCL1 TNF 24186876 2890170 This study tests the hypothesis that IL-17 and synergistically *mediate* [CXCL1] ( a potent neutrophil chemokine ) production by alveolar type II epithelial ( ATII ) cells via an NADPH oxidase dependent mechanism during lung I/R. Using a hilar clamp model , wild-type and p47 ( phox-/- ) ( NADPH oxidase-deficient ) mice underwent left lung I/R , with or without recombinant IL-17 and/or TNF-a treatment . Positive_regulation CXCL1 TNF 24186876 2890172 Conditioned media transfer from hypoxia-reoxygenation exposed iNKT cells and macrophages , major sources of IL-17 and , respectively , to ATII cells significantly *enhanced* [CXCL1] production , which was blocked by NADPH oxidase inhibitor . Positive_regulation CXCL1 TNF 24186876 2890178 These results demonstrate that IL-17 and synergistically *mediate* [CXCL1] production by ATII cells after I/R , via an NADPH oxidase dependent mechanism , to induce neutrophil infiltration and lung I/R injury . Positive_regulation CXCL1 TNF 24580964 2920073 In cultured astrocytes , *induced* robust [CXCL1] expression , which was dose-dependently decreased by NF?B inhibitor . Positive_regulation CXCL1 TNF 24719782 2932015 *induced* CCL2 , CCL7 , and [CXCL1] in preadipocytes but had no response in adipocytes . Positive_regulation CXCL1 TNF 8264646 247046 IL-1 and posttranscriptionally *regulate* [MGSA/GRO] mRNA levels in both cell types . Positive_regulation CXCL1 TNF 8344798 226498 Reverse-transcription polymerase chain reaction was used to determine the steady-state mRNA expression of three forms of [MGSA/gro] , alpha , beta , and gamma , by cultured human RPE cells in the *presence* or absence of recombinant IL-1 beta , , or TGF beta , or when serum starved cells were re-fed with medium containing serum . Positive_regulation CXCL10 CD14 20828409 2346312 B. burgdorferi stimulates PBMC or monocytes/macrophages directly to secrete CCL4 , but spirochetal stimulation of other intermediate cells , which are present in PBMC , is *required* to induce CD14+ cells to secrete CCL2 , CXCL9 and [CXCL10] . Positive_regulation CXCL10 EPHB2 11799150 902420 Activation of p38 and signaling during adenovirus vector cell entry *lead* to expression of the C-X-C chemokine [IP-10] . Positive_regulation CXCL10 EPHB2 15894298 1439862 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated kinase ( MEK ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL10 EPHB2 18291705 1924921 In cells expressing CXCR3-A , [CXCL10] ( IP-10 ) at nanomolar concentrations *induced* activation of , Akt , and Src , as previously described in human vascular pericytes . Positive_regulation CXCL10 EPHB2 19472212 2102233 JAKs inhibitors suppressed IFN-gamma plus TNF-alpha induced production of CXCL10 in parallel with activation of STAT1 and NF-kappaB , while inhibitor *suppressed* production of [CXCL10] as well as activation of NF-kappaB , but not that of STAT1 . Positive_regulation CXCL10 EPHB2 23964117 2873327 The induction of [IP-10] *required* , JNK , p38 MAPK , PKC , PTK , PI3K , and ROS . Positive_regulation CXCL10 FAS 12473267 1023191 Moreover , cross linking of by injection of anti-Fas antibody into mice *triggers* induction of [IP-10] and Mig in the liver . Positive_regulation CXCL10 IL1B 10092813 600784 We found that IFN-gamma , but not TNF-alpha or , strongly *induced* [IP-10] , Mig , and I-TAC mRNA accumulation mainly in NHBEC and that TNF-alpha and IL-1 beta synergized with IFN-gamma induction in all three cell types . Positive_regulation CXCL10 IL1B 15158019 1252565 Furthermore , we observed that LPS + *stimulated* [CXCL10] production is inhibited in human A172 astroglia exposed to chronic 50 mM ethanol . Positive_regulation CXCL10 IL1B 15197236 1281059 TNF-alpha but not *enhanced* the IFN-gamma induced production of MIG and [IP-10] . Positive_regulation CXCL10 IL1B 15774504 1397271 CXCL8 and CXCL1 production by human astrocytes at both the RNA and protein levels could be induced by interleukin (IL)-1beta , while [CXCL10] was *induced* by both and interferon-gamma . Positive_regulation CXCL10 IL1B 17484771 1778183 LPS induced production of tumour necrosis factor-alpha (TNF-alpha) , interleukin-6 (IL-6) , IL-10 and [interferon-gamma-inducible protein-10 (IP-10);] SA *induced* TNF-alpha , and production ; Positive_regulation CXCL10 IL1B 18046562 1852435 Real-time PCR and ELISA experiments using a specific NF-kappaB inhibitor and transfection experiments with a NF-kappaB binding defective CXCL10 promoter construct revealed that the *induction* of [CXCL10] by and its synergism with IFN-gamma is NF-kappaB dependent . Positive_regulation CXCL10 IL1B 19929594 2171905 In contrast to IFN-gamma , *induces* [ip-10] expression rapidly but transiently , by activating classical NF-kappaB and increasing the synthesis of IRF1 . Positive_regulation CXCL10 IL1B 19929594 2171908 Together , and IFN-gamma *induce* [ip-10] synergistically . Positive_regulation CXCL10 IL1B 19929594 2171912 IFN-gamma does not affect the transient activation of classical NF-kappaB by IL-1beta and synergistic *induction* of [ip-10] expression by IFN-gamma and occurs even after the activation of classical NF-kappaB has returned to basal levels . Positive_regulation CXCL10 MAP2K6 15894298 1439868 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated protein/ERK kinase ( ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL10 MAP2K6 17274000 1697176 Inhibitors of PI3 K , p38 MAPK , and *suppressed* IL-18 plus IFN-gamma induced CXCL9 , [CXCL10] , and CXCL11 production and NF-kappaB , STAT1 , and IRF-1 activities . Positive_regulation CXCL10 TLR7 23742950 2870539 Less effect of COX was seen on *induced* [IP-10] release . Positive_regulation CXCL10 TLR7 24048896 2851761 In these studies , we have identified Annexin-A1 (ANXA1) as a novel regulator of *induced* IFN-ß and [CXCL10] production . Positive_regulation CXCL10 TNF 10092813 600782 We found that IFN-gamma , but not or IL-1 beta , strongly *induced* [IP-10] , Mig , and I-TAC mRNA accumulation mainly in NHBEC and that TNF-alpha and IL-1 beta synergized with IFN-gamma induction in all three cell types . Positive_regulation CXCL10 TNF 10559511 566628 Ang II and *induced* the expression of [IP-10] ( 1.5 and 3.4-fold ) and MCP-1 ( 2.4 and 4-fold ) in VSMC . Positive_regulation CXCL10 TNF 10880246 709106 Pretreatment with GM-CSF selectively inhibited IL-1beta , but not *induced* [IP-10] mRNA expression . Positive_regulation CXCL10 TNF 10880246 709113 Our results demonstrated that chemokine induction is stimulus- , tissue- and cell type-specific and that IP-10 ( but not MCP-1 ) is inducible in hepatocytes by TNF-alpha most potently , even in the presence of GM-CSF , suggesting the specific role of *induced* [IP-10] on intralobular mononuclear infiltration in chronic hepatitis . Positive_regulation CXCL10 TNF 10903743 713116 IL-4 , but not IL-10 or IL-17 , significantly up-regulated IFN-gamma- or *induced* [IP-10] , Mig , and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants . Positive_regulation CXCL10 TNF 10903743 713124 In conclusion , IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and *induction* of [IP-10] , Mig , and I-TAC , which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites . Positive_regulation CXCL10 TNF 11431017 831749 Both RANTES and [IP-10] were *stimulated* by proinflammatory cytokine interferon-gamma (IFNgamma) , but only RANTES by , suggesting that virus infection induces chemokines overlapping with those inducible by proinflammatory cytokines . Positive_regulation CXCL10 TNF 11752021 898650 The *induction* of [IP-10] and Mig mRNA and protein expression by IFN-gamma plus was strongly inhibited by nitric oxide ( NO ) donors , such as sodium nitroprusside or S-nitroso-N-acetylpenicillamine , but not by cGMP analogues . Positive_regulation CXCL10 TNF 11752021 898656 Electrophoretic mobility shift assays demonstrated that NO donors repressed [IP-10] gene transcription *induced* by IFN-gamma plus through the inhibition of NF-kappaB activation . Positive_regulation CXCL10 TNF 11795279 892236 Lyso-PC inhibited IFN-gamma or IFN-gamma plus *induced* [IP-10] , Mig , and I-TAC mRNA expression but not that of the IRF-1 or IRF-1 dependent molecule , GBP . Positive_regulation CXCL10 TNF 12598219 1062030 In contrast to endotoxin , IA or interleukin-1 alpha did not *induce* [IP-10] or MIG mRNA in the lung . Positive_regulation CXCL10 TNF 14597565 1187423 In primary cultured hASM cells taken from normal donors , [CXCL10] protein expression was *induced* by IFN-gamma and , cytokines reported as elevated in COPD , and a synergistic response was obtained when they were combined . Positive_regulation CXCL10 TNF 14597565 1187428 *induced* [CXCL10] expression in hASM was dependent on NFkappaB activation , and a salicylanilide NFkappaB inhibitor blocked the CXCL10 expression . Positive_regulation CXCL10 TNF 15149503 1248386 is the main *inducer* of [IP-10] by skin fibroblasts , but not IFN-gamma or IL-4 . Positive_regulation CXCL10 TNF 15197236 1281057 but not IL-1beta *enhanced* the IFN-gamma induced production of MIG and [IP-10] . Positive_regulation CXCL10 TNF 15380914 1298562 The spontaneous and *stimulated* secretion of IL-1beta , IL-8 , [IP-10] and MIG from HT-29 and Caco-2 cells was tested with , or without pretreatment with allicin . Positive_regulation CXCL10 TNF 15644410 1394924 TRAIL pretreatment variably down modulated the mRNA steady-state levels of several TNF-alpha induced chemokines , and , in particular , it abrogated the *mediated* up-regulation of CCL8 and [CXCL10] . Positive_regulation CXCL10 TNF 15851567 1399543 [IP-10] synthesis is *induced* in HCKs by IL-1alpha , , and IFN-gamma . Positive_regulation CXCL10 TNF 15942713 1415769 also *stimulated* [IP-10] mRNA expression , but this was much weaker than that induced by IFN-gamma . Positive_regulation CXCL10 TNF 15942713 1415771 Trichostatin A , a specific inhibitor of histone deacetylase , also blocked the IFN-gamma- and *induced* [IP-10] mRNA expression , but the effects of trichostatin A were weaker than those of butyrate . Positive_regulation CXCL10 TNF 15963988 1428204 enhances phenotypic and functional maturation of human epidermal Langerhans cells and *induces* IL-12 p40 and [IP-10/CXCL-10] production . Positive_regulation CXCL10 TNF 16303841 1518805 dose dependent secretion of CXCL10 was not induced by TNFalpha alone , whereas stimulation with IFNgamma or plus IFNgamma *induced* [CXCL10] release . Positive_regulation CXCL10 TNF 16303841 1518807 Treatment of all cell types with the PPARgamma agonist , rosiglitazone , dose-dependently ( 0.1-10 microm ) suppressed IFNgamma- plus *induced* [CXCL10] release . Positive_regulation CXCL10 TNF 16436136 1516371 Either SCF or TNF-alpha could induce release from HMC-1 cells of interleukin (IL)-8 , monocyte chemoattractant protein (MCP)-1 , regulated upon activation normal T-cell expressed and secreted ( RANTES ) , and I-309 , while SCF and *induced* release of macrophage inflammatory protein (MIP)-1beta and [interferon-gamma-inducible protein-10 (IP-10)] , respectively . Positive_regulation CXCL10 TNF 16436136 1516403 Using various selective inhibitors for signaling molecules , we found that the inductions of IL-8 , MCP-1 , and I-309 were mediated by either SCF activated ERK or TNF-alpha activated p38 MAPK , while the *induction* of [IP-10] by was mediated by both activated p38 MAPK and NF-kappaB . Positive_regulation CXCL10 TNF 16776679 1573095 By PCR , fibroblasts expressed MCP-1 transcripts constitutively , whereas [IP-10] and Mig were *up-regulated* by . Positive_regulation CXCL10 TNF 17328963 1726374 Molecular characterization of cDNA encoding porcine IP-10 and induction of porcine endothelial [IP-10] in *response* to human . Positive_regulation CXCL10 TNF 17475341 1744121 Using MG-132 , helenalin and SN50 [ inhibitors of the transcription factor , nuclear factor (NF)-kappaB ] , we determined that NF-kappaB activation is instrumental in *induced* [CXCL10] expression in A172 astroglia . Positive_regulation CXCL10 TNF 17475341 1744122 However , fentanyl , a more potent mu-opioid receptor (MOR) agonist , inhibited *induced* [CXCL10] expression . Positive_regulation CXCL10 TNF 17475341 1744123 Interestingly , neither the non-selective opioid receptor antagonist , naltrexone nor beta-funaltrexamine ( beta-FNA ) , a highly selective MOR antagonist , blocked fentanyl mediated inhibition of *induced* [CXCL10] expression . Positive_regulation CXCL10 TNF 17475341 1744124 Rather , beta-FNA dose-dependently inhibited *induced* [CXCL10] expression with a greater potency than that observed for fentanyl . Positive_regulation CXCL10 TNF 17475341 1744126 These data show that beta-FNA and fentanyl inhibit *induced* [CXCL10] expression via a MOR independent mechanism . Positive_regulation CXCL10 TNF 17475341 1744127 Data also suggest that inhibition of *induced* [CXCL10] expression by fentanyl and beta-FNA is not directly related to a reduction in NF-kappaB p65 nuclear translocation . Positive_regulation CXCL10 TNF 17484771 1778182 LPS induced production of tumour necrosis factor-alpha (TNF-alpha) , interleukin-6 (IL-6) , IL-10 and [interferon-gamma-inducible protein-10 (IP-10);] SA *induced* , and IL-1beta production ; Positive_regulation CXCL10 TNF 17763126 1790291 Stimulation of HCE with either IL-1alpha or *increased* [IP-10] protein synthesis up to 6-fold , whereas insignificant levels of MIG and I-TAC were induced . Positive_regulation CXCL10 TNF 18239149 1884613 and IFNgamma , mainly when combined , *stimulate* [IFNgamma-inducible protein of 10 kDa (IP10)] and fractalkine production evaluated by ELISA and TaqMan analyses . Positive_regulation CXCL10 TNF 18372324 1925429 In human thyrocytes , elocalcitol inhibited IFNgamma and *induced* [CXCL10] protein secretion more potently than MMI . Positive_regulation CXCL10 TNF 18435806 1908193 We revealed that stimulation *induced* [CXCL10] production by HGFs . Positive_regulation CXCL10 TNF 18438854 1915453 However , [IP-10] did not *induce* RANKL or in CD8+ T cells . Positive_regulation CXCL10 TNF 18514095 1918358 However , the induction patterns of chemokines by these two cytokines were different , i.e. , involving predominant *induction* of [IP-10] and I-TAC by and induction of Mig by IFN-gamma . Positive_regulation CXCL10 TNF 18760623 1975407 After 48 h , also induced a significant *increase* in IL-1beta , IL-3 , and [IP-10] secretion . Positive_regulation CXCL10 TNF 18941244 1978178 IL-17 strongly repressed *stimulated* expression of [CXCL10] , CXCL11 , and CCL5 , but synergized with TNF-alpha for induction of CXCL8 , CXCL1 , and CCL20 mRNAs . Positive_regulation CXCL10 TNF 18973545 2041342 Human gingival fibroblasts produced [CXCL10] protein upon *stimulation* with interleukin-1beta , and interferon-gamma . Positive_regulation CXCL10 TNF 19014933 2016787 BXL-01-0029 inhibited IFNgamma and *induced* [CXCL10] secretion by Hfcm more potently than MPA , impairing cytokine synergy and pathways . Positive_regulation CXCL10 TNF 19029086 1992416 In contrast , *caused* an increase in CXCL9 ( 300-fold ) , [CXCL10] ( 2000-fold ) , and CXCL11 ( 2000-fold ) mRNA levels in GT1 , but not RT7 cells , at 24 hrs . Positive_regulation CXCL10 TNF 19442267 2090587 Seven out of nine ginsenosides could significantly inhibit *induced* [CXCL-10] expression in U937 cells and give comparable inhibition of CXCL-10 transcription to those with the extract . Positive_regulation CXCL10 TNF 19472212 2102248 These results suggest that *induces* [CXCL10] production by activating NF-kappaB through ERK and that IFN-gamma induces CXCL10 production by increasing the activation of STAT1 through JAKs pathways . Positive_regulation CXCL10 TNF 19472212 2102256 IFN-gamma potentiates *induced* [CXCL10] production in THP-1 cells by increasing the activation of STAT1 and NF-kappaB through JAK1 and JAK2 . Positive_regulation CXCL10 TNF 19559500 2216625 Lidocaine inhibited spontaneous and *induced* secretion of IL-8 and [IP-10] . Positive_regulation CXCL10 TNF 19607809 2123910 Both OA-NO ( 2 ) and LNO ( 2 ) prevented *stimulated* release of the cytokines , IL-6 , IL-8 , IL-12/p40 , IFNgamma , MCP-1 , and [IP-10] , and inhibited NF-kappaB activation . Positive_regulation CXCL10 TNF 19755523 2163447 alone *induced* a slight but significant [CXCL10] secretion only in PTCs . Positive_regulation CXCL10 TNF 19755523 2163449 The stimulation with *induced* a synergistic [CXCL10] release in both cell types ; Positive_regulation CXCL10 TNF 19755523 2163451 Treatment of TFC with TZDs dose-dependently suppressed *induced* [CXCL10] release , while TZDs stimulated CXCL10 secretion in PTCs . Positive_regulation CXCL10 TNF 19755523 2163453 In fact , a [CXCL10] secretion more than ten times higher has been *induced* by in PTCs with respect to TFC . Positive_regulation CXCL10 TNF 20062995 2225443 *induced* production of [IP-10] , but not IL-15 in cultured synovial cells from RA patients . Positive_regulation CXCL10 TNF 20299237 2254756 In conclusion , IFNalpha , IFNbeta , IFNgamma and ( synergistically with IFNs ) dose-dependently *induce* the release of CXCL9 and [CXCL10] by TFC , suggesting that this process may be related , at least in part , to the appearance of thyroid dysfunction during IFNs therapy . Positive_regulation CXCL10 TNF 21371758 2426548 Significant and dose dependent secretions of [CXCL10] were *induced* by IFN-ß but not GA. synergistically increased IFN-ß induced CXCL10 secretion . Positive_regulation CXCL10 TNF 21454254 2448145 [IP-10] induction is further *potentiated* by signaling , preferentially via the TNF-a receptor subtype 2 selectively increased upon stimulation of viral receptors in the proinflammatory milieu . Positive_regulation CXCL10 TNF 22038897 2513760 CAPE significantly inhibited *induced* [IP-10] expression in intestinal epithelial cells . Positive_regulation CXCL10 TNF 22387292 2593160 Cytomix , IL-1ß , and *induced* [CXCL10] mRNA expression more rapidly in asthmatic than nonasthmatic ASM cells . Positive_regulation CXCL10 TNF 22387292 2593162 IL-1ß and/or combined with IFN-? synergistically *increased* asthmatic ASM cell [CXCL10] release . Positive_regulation CXCL10 TNF 22633083 2614809 ( c ) did not *induce* [CXCL10] secretion , in ANA and TFC ; Positive_regulation CXCL10 TNF 22633083 2614811 ( d ) *induced* a synergistic but variable release of [CXCL10] in the different ANA preparations , while it was more reproducible in TFC ; Positive_regulation CXCL10 TNF 22895606 2672053 Tacrolimus ( FK506 ) suppresses *induced* CCL2 ( MCP-1 ) and [CXCL10] ( IP-10 ) expression via the inhibition of p38 MAP kinase activation in human colonic myofibroblasts . Positive_regulation CXCL10 TNF 22944249 2757225 It has been previously shown IFN-a , -ß , -? and ( synergically with IFNs ) dose-dependently *induce* the release of CXCL9 and [CXCL10] chemokines by thyroid follicular cells , suggesting that this process may be related , at least in part , to the appearance of thyroid dysfunction during IFNs therapy . Positive_regulation CXCL10 TNF 23278752 2752358 Moreover , TLR agonists differentially regulated *induced* IL-8 and [CXCL10] production by the tested cell types . Positive_regulation CXCL10 TNF 23460644 2776486 Compared with , IFN-? treatment induced significantly more CXCL-10 , and both factors *increased* synthesis of [CXCL-10] in the presence of decorin . Positive_regulation CXCL10 TNF 23524263 2772275 LL-37 inhibited the increase of [CXCL10] and CCL5 *induced* by and/or IFN-? but enhanced that of CXCL8 . Positive_regulation CXCL10 TNF 23600829 2774473 Furthermore , IL-37b inhibited *induced* [interferon-?-inducible protein (IP)-10] expression significantly in human colonic SEMFs . Positive_regulation CXCL10 TNF 24753255 2950058 Furthermore , NF-?B p65 , a critical driver of mediated [CXCL10] *induction* , was determined to be methylated at arginine residues . Positive_regulation CXCL10 TNF 25001926 2948321 IFN-? plus *increased* mRNA and protein expressions of CXCL9 , [CXCL10] and CXCL11 in HK-2 cells . Positive_regulation CXCL10 TNF 7730628 302373 Together these results indicate that the highly synergistic transcriptional *activation* of the [IP-10] gene by IFN-gamma and involves the cooperation between factors that are independently activated by the two stimuli and that bind to independent sites . Positive_regulation CXCL10 TNF 9681518 521333 Conversely , [IP-10] mRNA levels were markedly increased in *response* to murine interleukin-1alpha , murine , and murine IFNgamma by 3.3- , 10- , and 26-fold , respectively . Positive_regulation CXCL11 EPHB2 15894298 1439884 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated kinase ( MEK ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL11 IL1B 10092813 600787 We found that IFN-gamma , but not TNF-alpha or , strongly *induced* IP-10 , Mig , and [I-TAC] mRNA accumulation mainly in NHBEC and that TNF-alpha and IL-1 beta synergized with IFN-gamma induction in all three cell types . Positive_regulation CXCL11 IL1B 16847431 1600268 In analogy with TLR ligands , tumor necrosis factor-alpha (TNF-alpha) or , in combination with IFN-gamma , synergistically *induced* CXCL9 and [CXCL11] in HMVEC and human fibroblasts , two fundamental cell types delineating the joint cavity . Positive_regulation CXCL11 MAP2K6 15894298 1439890 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated protein/ERK kinase ( ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL11 MAP2K6 17274000 1697198 Inhibitors of PI3 K , p38 MAPK , and *suppressed* IL-18 plus IFN-gamma induced CXCL9 , CXCL10 , and [CXCL11] production and NF-kappaB , STAT1 , and IRF-1 activities . Positive_regulation CXCL11 MUC16 16466101 1523360 We studied the *role* of cytokeratin ( CK ) and expression in differentiating [ITAC] , metastatic adenocarcinoma of intestinal origin , and non-intestinal-type sinonasal adenocarcinoma ( non-ITAC ) . Positive_regulation CXCL11 TNF 10092813 600785 We found that IFN-gamma , but not or IL-1 beta , strongly *induced* IP-10 , Mig , and [I-TAC] mRNA accumulation mainly in NHBEC and that TNF-alpha and IL-1 beta synergized with IFN-gamma induction in all three cell types . Positive_regulation CXCL11 TNF 10395932 627649 For these cell types , IFN-gamma was a potent inducer of [CXCL 11] transcription , which was synergistically *enhanced* by . Positive_regulation CXCL11 TNF 10843686 700138 IFN-gamma induction of murine [I-TAC] is markedly *enhanced* by costimulation with LPS or IL-1beta in RAW cells and by in both RAW cells and Swiss 3T3 fibroblasts . Positive_regulation CXCL11 TNF 10903743 713119 IL-4 , but not IL-10 or IL-17 , significantly up-regulated IFN-gamma- or *induced* IP-10 , Mig , and [I-TAC] mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants . Positive_regulation CXCL11 TNF 10903743 713125 In conclusion , IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and *induction* of IP-10 , Mig , and [I-TAC] , which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites . Positive_regulation CXCL11 TNF 15851567 1399537 In contrast , stimulation with , IL-1alpha , or IFN-gamma *induced* levels of MIG and [I-TAC] that were not significantly greater than constitutive levels . Positive_regulation CXCL11 TNF 16847431 1600267 In analogy with TLR ligands , or interleukin-1beta (IL-1beta) , in combination with IFN-gamma , synergistically *induced* CXCL9 and [CXCL11] in HMVEC and human fibroblasts , two fundamental cell types delineating the joint cavity . Positive_regulation CXCL11 TNF 18514095 1918360 However , the induction patterns of chemokines by these two cytokines were different , i.e. , involving predominant *induction* of IP-10 and [I-TAC] by and induction of Mig by IFN-gamma . Positive_regulation CXCL11 TNF 18941244 1978179 IL-17 strongly repressed *stimulated* expression of CXCL10 , [CXCL11] , and CCL5 , but synergized with TNF-alpha for induction of CXCL8 , CXCL1 , and CCL20 mRNAs . Positive_regulation CXCL11 TNF 18987152 2015280 Furthermore , HCV can selectively increase [CXCL11] expression in *response* to IFN-gamma and stimulation that may play a role in the pathogenesis of HCV related liver disease . Positive_regulation CXCL11 TNF 19029086 1992417 In contrast , *caused* an increase in CXCL9 ( 300-fold ) , CXCL10 ( 2000-fold ) , and [CXCL11] ( 2000-fold ) mRNA levels in GT1 , but not RT7 cells , at 24 hrs . Positive_regulation CXCL11 TNF 22944249 2757230 In conclusion , we first show that IFN-a , -ß and -? and ( synergically with IFNs ) dose-dependently *induce* the release of [CXCL11] by primary cultures of human thyroid follicular cells , suggesting that this process may be related to the appearance of thyroid dysfunction during IFNs therapy . Positive_regulation CXCL11 TNF 25001926 2948322 IFN-? plus *increased* mRNA and protein expressions of CXCL9 , CXCL10 and [CXCL11] in HK-2 cells . Positive_regulation CXCL12 ANGPT1 21200018 2414288 Furthermore , [SDF-1] *stimulation* by was blocked by small interfering RNA ( siRNA ) against hypoxia-inducible factor-1a (HIF-1a) . Positive_regulation CXCL12 ANGPT1 22558265 2591217 Overexpression of *resulted* in a significant increase in [CXCR-4/SDF-1a] expression and promoted CD133 ( + ) /c-kit ( + ) , CD133 ( + ) /CXCR-4 ( + ) and CD133 ( + ) /SDF-1a ( + ) cell recruitment into ischemic hearts . Positive_regulation CXCL12 EPHB2 12783869 1119868 Adhesion regulation of [stromal cell derived factor-1] *activation* of in lymphocytes by phosphatases . Positive_regulation CXCL12 EPHB2 12783869 1119869 *Activation* of by the chemokine [SDF-1] can be regulated by adhesion to beta 1-integrin substrates in the T-cell lines MOLT-3 , Jurkat , and H9 and in the Daudi B-cell line . Positive_regulation CXCL12 EPHB2 12783869 1119871 In Jurkat T-cells , adhesion to the immobilized alpha 4 beta 1-integrin ligand VCAM-1 or to the alpha 5 beta 1-integrin ligand fibronectin regulated [stromal-cell derived factor-1 (SDF-1)] *activation* of . Positive_regulation CXCL12 EPHB2 12783869 1119879 Therefore , these data suggest that adhesion influences [SDF-1] *activation* of by regulating the activity of ERK phosphatases . Positive_regulation CXCL12 EPHB2 15894298 1439994 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated kinase ( MEK ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL12 EPHB2 16919488 1602804 This pathway is responsible for several of the effects of SDF-1alpha on T cells , including prolonged MAP kinase activity , increased intracellular calcium ion concentrations , robust AP-1 transcriptional activity , and [SDF-1alpha] *costimulation* of cytokine secretion . Positive_regulation CXCL12 EPHB2 17169599 1688001 The OSM stimulated expression of SDF-1 in hATSCs was completely abrogated by pretreatment of the cells with U0126 , an MEK-specific inhibitor , but not with AG490 , a JAK2 inhibitor , or WHI-P131 , a JAK3 inhibitor , suggesting that , but not JAK2 and JAK3 , is *involved* in the OSM induced expression of [SDF-1] . Positive_regulation CXCL12 F2R 16141404 1475541 activation also increased CXCR4 expression on EPC and *induced* [SDF-1] secretion , leading to autocrine stimulation . Positive_regulation CXCL12 IL1B 11673556 872882 On the other hand , CCL2 , CCL5 , and [CXCL12] were expressed on RA FLS , and their production was *regulated* by TNF-alpha , , and TGF-beta1 . Positive_regulation CXCL12 IL1B 16782208 1590851 Experiments in vitro demonstrated that and myelin basic protein (MBP) *induced* [CXCL12] in astrocytes by signaling pathways involving ERK and PI3-K . Positive_regulation CXCL12 IL1B 16944452 1609898 This [SDF-1] production was directly *dependent* on MDM following both viral and immune activation . Positive_regulation CXCL12 ITGB2 21850266 2468775 These results suggested that HK-2 cells stimulated with TGF-ß ( 1 ) induced conformational *activation* of on PBMCs by increased [CXCL12] . Positive_regulation CXCL12 MAP2K6 12783869 1119877 In contrast , [SDF-1] *activation* of the ERK kinase was independent of adhesion . Positive_regulation CXCL12 MAP2K6 15894298 1440000 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated protein/ERK kinase ( ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL12 MMP28 16169519 1461627 Moreover , the enhanced production of [SDF-1alpha] was *suppressed* by the inhibitor . Positive_regulation CXCL12 MMP7 16169519 1461642 Moreover , the enhanced production of [SDF-1alpha] was *suppressed* by the inhibitor . Positive_regulation CXCL12 PLAU 21465475 2523636 SK-Hep-1 cells stimulation with *induced* increases in the expression and secretion of [SDF-1] . Positive_regulation CXCL12 PLAU 21465475 2523637 By using specific inhibitors and small interfering RNA , we have demonstrated that the activation of extracellular signal related kinase ( ERK ) and c-Jun-NH ( 2 ) -terminal kinase ( JNK ) pathways are critical for *induced* [SDF-1] expression . Positive_regulation CXCL12 PLAU 21465475 2523641 Inhibition of Sp1 and AP-1 activations by specific siRNAs blocked the *induced* [SDF-1] promoter activity and expression . Positive_regulation CXCL12 PLAU 21494253 2458316 Additionally , ROS inhibition reduced AMD3100 induced [SDF-1] release , *activation* of circulating and mobilization of progenitor cells . Positive_regulation CXCL12 S100B 21209080 2391853 The *dependent* activation of diaphanous-1/Rac1/JNK/AP-1 , Ras/Rac1/NF-?B and Src/Ras/PI3K/RhoA/diaphanous-1 results in the up-regulation of expression of the chemokines , CCL3 , CCL5 , and [CXCL12] , whose release and activity are required for S100B to stimulate microglia migration . Positive_regulation CXCL12 STK39 12743331 1088437 These cell lines responded to [SDF-1] *stimulation* by chemotaxis , phosphorylation of mitogen activated protein kinase (MAPK) p42/44 and AKT , and calcium flux , confirming the functionality of the CXCR4 receptor . Positive_regulation CXCL12 TNF 11673556 872881 On the other hand , CCL2 , CCL5 , and [CXCL12] were expressed on RA FLS , and their production was *regulated* by , IL-1beta , and TGF-beta1 . Positive_regulation CXCL12 TNF 16565491 1539043 In conclusion , the interaction of [SDF-1] released from fibroblasts and CXCR4 expressed on ICC cells may be actively involved in ICC migration , and may *enhance* ICC cell migration by increasing CXCR4 expression . Positive_regulation CXCL12 TNF 18040270 1846618 The chemokine [SDF-1alpha] mediates firm adhesion c-kit+ cells only in the *presence* of stimulation via an ICAM-1- and CXCR4 dependent mechanism . Positive_regulation CXCL12 TNF 18292573 1872978 Furthermore , the homeostatic chemokine [CXCL12] was *up-regulated* by LIGHT and LTalpha1beta2 but not in both HUVEC and HDMEC . Positive_regulation CXCL12 TNF 19563019 2099703 treatment *induced* significantly higher [SDF-1] alpha expression on osteoblastic and stromal cells in bone marrow , and reversed spleen SDF-1 alpha gradient that was originally favorable for CD34+ cells homing . Positive_regulation CXCL12 TNF 23266741 2741450 Furthermore , IFN-? and *induced* BM endothelial cells to express high levels of the inflammatory chemokines and reduced or unaltered levels of [CXCL12] . Positive_regulation CXCL13 EPHB2 15894298 1439906 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated kinase ( MEK ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL13 IL1B 15050303 1229341 , significantly *induced* [CXCL13] production in differentiated OB , both from OA and PT patients , but not in BMSC from both either group . Positive_regulation CXCL13 MAP2K6 15894298 1439912 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated protein/ERK kinase ( ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL14 EPHB2 15894298 1439928 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated kinase ( MEK ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL14 MAP2K6 15894298 1439934 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated protein/ERK kinase ( ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL16 EPHB2 15883016 1406562 Thus , our data indicate that [CXCL16] may act as a novel angiogenic factor for HUVEC and that is *involved* as an important signaling molecule to mediate its angiogenic effects . Positive_regulation CXCL16 EPHB2 15894298 1440016 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated kinase ( MEK ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL16 IL1B 17459077 1749907 On the other hand , IL-4 and IL-13 inhibited the *induced* [CXCL16] production by HGFs . Positive_regulation CXCL16 IL1B 18344492 1892186 Finally , we found that both and tumor necrosis factor alpha significantly *induced* [CXCL16] production by prostate epithelial cells , thereby indicating that inflammatory cytokines may play a role in the CXCL16 induction . Positive_regulation CXCL16 MAP2K6 15894298 1440022 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated protein/ERK kinase ( ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL16 TNF 15128827 1245278 The transmembrane [CXC-chemokine ligand 16] is *induced* by IFN-gamma and and shed by the activity of the disintegrin-like metalloproteinase ADAM10 . Positive_regulation CXCL16 TNF 15880344 1406202 In vitro studies revealed that monocytes started to express CXCL16 upon differentiation into macrophages , and that RA SF and *enhanced* [CXCL16] expression . Positive_regulation CXCL16 TNF 16410312 1513712 *induced* expression of [CXCL16] depends on NFkappaB , p38 MAPK and PKA . Positive_regulation CXCL16 TNF 16508941 1530322 Interestingly , RA ST fibroblasts did not produce [CXCL16] in *response* to in vitro , suggesting that CXCL16 protein may function in large part independently of TNFalpha . Positive_regulation CXCL16 TNF 17712227 1829816 ID8 cells constitutively expressed [CXCL16] and CCL2 , but only CCL2 expression was *enhanced* by LPS , IL-1 and . Positive_regulation CXCL17 EPHB2 15894298 1440038 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated kinase ( MEK ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL17 MAP2K6 15894298 1440044 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated protein/ERK kinase ( ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL17 MMP28 18315355 1880689 Treating the cells with GM6001 , an inhibitor , *blocked* the cleavage of [DMC] and caused an increase of the DsRed2/CFP ratio . Positive_regulation CXCL17 MMP7 18315355 1880704 Treating the cells with GM6001 , an inhibitor , *blocked* the cleavage of [DMC] and caused an increase of the DsRed2/CFP ratio . Positive_regulation CXCL2 CHI3L1 21866546 2599263 We found that in vitro inhibition of by siRNA *suppressed* the production of CCL2 , [CXCL2] and MMP-9 by macrophages . Positive_regulation CXCL2 EPHB2 15894298 1440082 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated kinase ( MEK ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL2 IL1B 20182449 2272431 IL-1alpha and *increased* mRNA production and protein secretion of the neutrophil chemotactic CXCL1 , [CXCL2] , and IL-8 in keratinocytes . Positive_regulation CXCL2 MAP2K6 15894298 1440088 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated protein/ERK kinase ( ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL2 TLR7 24920846 2946700 Levels of *stimulated* CXCL1 and [CXCL2] but not CXCL10 or CCL5 mRNAs were selectively enhanced ( > 10-fold ) in stressed macrophages . Positive_regulation CXCL2 TNF 12823853 1104333 Among these genes we identified the following : *stimulated* gene-6 ( TSG-6 ) , IL-6 , IL-8 , [GRO-beta] , and bone morphogenetic protein-6 with an expression 3.6-10.6-fold that in the unstimulated control . Positive_regulation CXCL2 TNF 12892904 1117856 Interleukin-1 beta , and interferon-gamma significantly *stimulated* the expression of [GRO beta] by HHUA and ESC . Positive_regulation CXCL2 TNF 16771850 1572682 However , it remains elusive whether enterocytes release [CXCL2] in *response* to LPS and via a NF-kappaB dependent pathway and whether this involves the endogenous production of TNF and PAF . Positive_regulation CXCL2 TNF 16771850 1572696 In this study , we found that and LPS markedly *induced* [CXCL2] gene expression in IEC-6 cells , TNF within 30 min , peaking at 45 min , while LPS more slowly , peaking after 2 hr. TNF- and LPS- induced CXCL2 gene expression and protein release were completely blocked by pyrrolidine dithiocarbamate ( PDTC ) and helenalin , two potent NF-kappaB inhibitors . Positive_regulation CXCL2 TNF 16771850 1572697 In conclusion , [CXCL2] gene is expressed in enterocytes in *response* to both and LPS . Positive_regulation CXCL2 TNF 17424890 1723871 *stimulates* the expression of C-C [chemokine ligand 2] gene in fibroblasts from the human nasal polyp through the pathways of mitogen activated protein kinase . Positive_regulation CXCL2 TNF 18835392 1981793 In colon epithelial cells , *induction* of [MIP-2 alpha] expression by was accompanied by a concomitant reduction in miR-192 expression and miR-192 was observed to regulate the expression of MIP-2 alpha . Positive_regulation CXCL2 TNF 19454709 2084584 Despite receptor expression , IL-17 was relatively ineffective at eliciting glial activation , whereas the cytokine augmented the ability of to *induce* [CXCL2] and CCL2 expression by macrophages . Positive_regulation CXCL2 TNF 19786552 2147705 Of particular interest , *induced* expression of cytokines/chemokines , such as IL-6 and [CXCL-2] , was impaired in FAN-deficient cells . Positive_regulation CXCL2 TNF 20237297 2237983 Neutrophils were rapidly attracted to the tumor site by an IL-17 dependent mechanism , but at later stages the *induction* of the chemokine [CXCL2] by Tc17 derived and IFN-gamma contributed to sustain neutrophil recruitment . Positive_regulation CXCL3 EPHB2 15894298 1440104 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated kinase ( MEK ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL3 MAP2K6 15894298 1440110 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated protein/ERK kinase ( ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL5 ANGPT1 24404127 2900492 While TNF enhanced expression of a common restricted set of genes involved in angiogenesis and inflammation in GM-CSF , IFN-? and IL-10 -differentiated macrophages , expression of multiple chemokines and cytokines , including CXCL3 , [CXCL5] , CXCL8 , IL6 , and IL12B was further augmented in the *presence* of and Ang-2 , via Tie2 activation of JAK/STAT signaling . Positive_regulation CXCL5 EPHB2 15894298 1439950 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated kinase ( MEK ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL5 IL1B 11331668 808908 Progesterone , lipopolysaccharide , tumour necrosis factor-alpha , and significantly *stimulated* the expression of [ENA-78] by ESC . Positive_regulation CXCL5 IL1B 13679321 1185651 Production of [ENA-78] by amnion monolayers was *stimulated* in a concentration dependent fashion by both and tumor necrosis factor alpha . Positive_regulation CXCL5 IL1B 14580366 1156926 15d-PGJ ( 2 ) inhibited the *induced* expression of [ENA-78] , but not the expression of IL-8 or GRO-alpha in response to IL-1 . Positive_regulation CXCL5 IL1B 16869002 1607358 Treatment with EGCG at 10 microM or 20 microM significantly inhibited *induced* [ENA-78] , RANTES , and GROalpha , but not MCP-1 production in a concentration dependent manner . Positive_regulation CXCL5 IL1B 16869002 1607359 EGCG at 50 microM caused a complete block of *induced* production of RANTES , [ENA-78] , and GROalpha , and reduced production of MCP-1 by 48 % ( P < 0.05 ) . Positive_regulation CXCL5 IL1B 1744577 171911 In *response* to stimulation with either or tumor necrosis factor alpha (TNF-alpha) , [ENA-78] was produced and secreted concomitantly with IL-8 , GRO alpha , and GRO gamma . Positive_regulation CXCL5 IL1B 19056796 2017699 Among various chemokines [ such as monocyte chemoattractant protein-1 ( MCP-1 ) , GRO-alpha , regulated upon activation , normal T-cell expressed and presumably secreted ( RANTES ) and epithelial neutrophil activating peptide 78 ( ENA-78 ) ] , cordycepin specifically blocked *induced* [ENA-78] production in RASF . Positive_regulation CXCL5 MAP2K6 14557379 1165082 Furthermore , selective mitogen activated protein kinase kinase ( ) inhibitors 2'-amino-3'-methoxyflavone ( PD98059 ) , 1,4-diamino-2,3-dicyano-1,4-bis ( o-aminophenylmercapto ) butadiene ( U0126 ) , and Raf1 kinase inhibitor I partially *inhibited* Ml-1 induced GROalpha and [ENA-78] production . Positive_regulation CXCL5 MAP2K6 15894298 1439956 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated protein/ERK kinase ( ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL5 TNF 12882792 1116327 [ENA-78] gene expression is significantly enhanced in both HCECs and HCKs in *response* to either IL-1alpha or stimulation . Positive_regulation CXCL5 TNF 1744577 171910 In *response* to stimulation with either interleukin 1 beta (IL-1 beta) or , [ENA-78] was produced and secreted concomitantly with IL-8 , GRO alpha , and GRO gamma . Positive_regulation CXCL5 TNF 21282514 2392979 Because the T cell derived cytokine IL-17A enhances host defense by triggering production of chemokines , particularly in combination with TNF-a , we hypothesized that IL-17A would enhance *induced* expression of [CXCL5] . Positive_regulation CXCL5 TNF 21282514 2392981 Using differentiated alveolar epithelial type II ( ATII ) cells derived from human fetal lung , we found that IL-17A enhanced *induced* [CXCL5] transcription and stabilized TNF-a induced CXCL5 transcripts . Positive_regulation CXCL5 TNF 7814607 292697 These findings support the notion that pulmonary [ENA-78] produced in *response* to hepatic derived is an important mediator of lung injury . Positive_regulation CXCL5 TNF 8961388 402321 To determine whether [ENA-78] release was *induced* by is this model , rats were treated with neutralizing anti-TNF serum and hepatic ENA-78 levels measured 6 h posthepatectomy . Positive_regulation CXCL5 TNF 8961388 402323 ENA-78 levels were significantly decreased in the animals receiving the anti-TNF serum , suggesting that [ENA-78] is released in *response* to in this model . Positive_regulation CXCL5 TNF 8961388 402325 These data suggest that *triggers* the release of [ENA-78] following 70 % hepatectomy and that ENA-78 contributes to the hepatic neutrophil influx and liver injury following 70 % hepatectomy . Positive_regulation CXCL6 EPHB2 15894298 1439972 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated kinase ( MEK ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL6 IL1B 16721367 1570368 Production and *upregulation* of [granulocyte chemotactic protein-2/CXCL6] by and hypoxia in small cell lung cancer . Positive_regulation CXCL6 IL1B 17827342 1823046 Furthermore , the *induction* of [CXCL6/GCP-2] in endothelial cells by was enhanced synergistically by TNF-alpha but inhibited by IFN-gamma , which synergized with IL-1beta to produce the angiostatic CXCL10/IFN-gamma induced protein-10 . Positive_regulation CXCL6 IL1B 9164944 432137 [GCP-2] is *induced* in MG-63 , but not A549 cells by TNF-alpha , , and LPS , while ENA-78 is expressed in both cell types . Positive_regulation CXCL6 MAP2K6 15894298 1439978 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated protein/ERK kinase ( ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL6 PPBP 18707017 2020377 *Induction* of differentially expressed chemokines CXCL1-3 , CXCL5 , and [CXCL6] as well as LIF and gp130 in MSC by was verified by real-time polymerase chain reaction . Positive_regulation CXCL6 TNF 17827342 1823045 Furthermore , the induction of [CXCL6/GCP-2] in endothelial cells by IL-1beta was *enhanced* synergistically by but inhibited by IFN-gamma , which synergized with IL-1beta to produce the angiostatic CXCL10/IFN-gamma induced protein-10 . Positive_regulation CXCL6 TNF 19686583 2138955 IL-17 and synergistically *induced* [granulocyte chemotactic protein-2] ( GCP-2 ) , IL-6 and receptor activator of NFkappaB ligand ( RANKL ) in MEF . Positive_regulation CXCL6 TNF 9164944 432136 [GCP-2] is *induced* in MG-63 , but not A549 cells by , IL-1beta , and LPS , while ENA-78 is expressed in both cell types . Positive_regulation CXCL9 CD14 20828409 2346313 B. burgdorferi stimulates PBMC or monocytes/macrophages directly to secrete CCL4 , but spirochetal stimulation of other intermediate cells , which are present in PBMC , is *required* to induce CD14+ cells to secrete CCL2 , [CXCL9] and CXCL10 . Positive_regulation CXCL9 EPHB2 15894298 1440126 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated kinase ( MEK ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL9 FAS 12473267 1023192 Moreover , cross linking of by injection of anti-Fas antibody into mice *triggers* induction of IP-10 and [Mig] in the liver . Positive_regulation CXCL9 IL1B 10092813 600799 We found that IFN-gamma , but not TNF-alpha or , strongly *induced* IP-10 , [Mig] , and I-TAC mRNA accumulation mainly in NHBEC and that TNF-alpha and IL-1 beta synergized with IFN-gamma induction in all three cell types . Positive_regulation CXCL9 IL1B 15197236 1281062 TNF-alpha but not *enhanced* the IFN-gamma induced production of [MIG] and IP-10 . Positive_regulation CXCL9 IL1B 16847431 1600274 In analogy with TLR ligands , tumor necrosis factor-alpha (TNF-alpha) or , in combination with IFN-gamma , synergistically *induced* [CXCL9] and CXCL11 in HMVEC and human fibroblasts , two fundamental cell types delineating the joint cavity . Positive_regulation CXCL9 MAP2K6 15894298 1440132 Our data also demonstrate that M. bovis BCG induced [CXC chemokine ligand (CXCL)8] release in epithelial cells was *reduced* by a mitogen activated protein/ERK kinase ( ) inhibitor ( PD98059 ) , but not by a p38 MAPK ( SB203580 ) inhibitor . Positive_regulation CXCL9 MAP2K6 17274000 1697287 Inhibitors of PI3 K , p38 MAPK , and *suppressed* IL-18 plus IFN-gamma induced [CXCL9] , CXCL10 , and CXCL11 production and NF-kappaB , STAT1 , and IRF-1 activities . Positive_regulation CXCL9 TNF 10092813 600797 We found that IFN-gamma , but not or IL-1 beta , strongly *induced* IP-10 , [Mig] , and I-TAC mRNA accumulation mainly in NHBEC and that TNF-alpha and IL-1 beta synergized with IFN-gamma induction in all three cell types . Positive_regulation CXCL9 TNF 10903743 713122 IL-4 , but not IL-10 or IL-17 , significantly up-regulated IFN-gamma- or *induced* IP-10 , [Mig] , and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants . Positive_regulation CXCL9 TNF 10903743 713126 In conclusion , IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and *induction* of IP-10 , [Mig] , and I-TAC , which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites . Positive_regulation CXCL9 TNF 11696601 877516 *dependent* segmental control of [MIG] expression by high endothelial venules in inflamed lymph nodes regulates monocyte recruitment . Positive_regulation CXCL9 TNF 11876523 918936 Chemokines are produced in a coordinated and sequential manner , with IL-8 and RANTES *induced* by during early stages , and MCP-1 , IP-10 , [Mig] , I-TAC , I-309 and MDC induced by IFN-gamma during later stages . Positive_regulation CXCL9 TNF 1429211 202525 *stimulates* colony formation by a megakaryoblastic leukemia cell line , [CMK] . Positive_regulation CXCL9 TNF 15197236 1281060 but not IL-1beta *enhanced* the IFN-gamma induced production of [MIG] and IP-10 . Positive_regulation CXCL9 TNF 15380914 1298564 The spontaneous and *stimulated* secretion of IL-1beta , IL-8 , IP-10 and [MIG] from HT-29 and Caco-2 cells was tested with , or without pretreatment with allicin . Positive_regulation CXCL9 TNF 15851567 1399540 In contrast , stimulation with , IL-1alpha , or IFN-gamma *induced* levels of [MIG] and I-TAC that were not significantly greater than constitutive levels . Positive_regulation CXCL9 TNF 16776679 1573096 By PCR , fibroblasts expressed MCP-1 transcripts constitutively , whereas IP-10 and [Mig] were *up-regulated* by . Positive_regulation CXCL9 TNF 16847431 1600273 In analogy with TLR ligands , or interleukin-1beta (IL-1beta) , in combination with IFN-gamma , synergistically *induced* [CXCL9] and CXCL11 in HMVEC and human fibroblasts , two fundamental cell types delineating the joint cavity . Positive_regulation CXCL9 TNF 16847431 1600295 Etanercept , a humanized soluble recombinant p75 TNF-receptor/IgG ( 1 ) Fc fusionprotein , neutralized synergistic [CXCL9] production *induced* by plus IFN-gamma , but not synergy between IFN-gamma and the TLR ligands PGN or LPS . Positive_regulation CXCL9 TNF 17016623 1629962 The Th1 cytokines CXCL9/MIG and CXCL10/IP-10 and the chemokine CCL5/RANTES were regulated in a distinct manner : Whereas histamine inhibited the *induced* secretion of [MIG] via the histamine receptor subtypes H1 , H2 , and H3 , the histamine induced suppression of RANTES was due to activation of the H2 and H3 receptors , while reduction of cytokine triggered IP-10 secretion was mediated only by triggering the H2 receptor . Positive_regulation CXCL9 TNF 18514095 1918362 However , the induction patterns of chemokines by these two cytokines were different , i.e. , involving predominant induction of IP-10 and I-TAC by and *induction* of [Mig] by IFN-gamma . Positive_regulation CXCL9 TNF 19029086 1992418 In contrast , *caused* an increase in [CXCL9] ( 300-fold ) , CXCL10 ( 2000-fold ) , and CXCL11 ( 2000-fold ) mRNA levels in GT1 , but not RT7 cells , at 24 hrs . Positive_regulation CXCL9 TNF 19276231 2072865 Treating all cell types with the PPARgamma agonist , rosiglitazone , or pioglitazone , the IFNgamma plus *induced* [CXCL9] and CXCL11 release was dose dependently ( 0.1-20 microm ) suppressed . Positive_regulation CXCL9 TNF 20299237 2254762 In conclusion , IFNalpha , IFNbeta , IFNgamma and ( synergistically with IFNs ) dose-dependently *induce* the release of [CXCL9] and CXCL10 by TFC , suggesting that this process may be related , at least in part , to the appearance of thyroid dysfunction during IFNs therapy . Positive_regulation CXCL9 TNF 22944249 2757228 It has been previously shown IFN-a , -ß , -? and ( synergically with IFNs ) dose-dependently *induce* the release of [CXCL9] and CXCL10 chemokines by thyroid follicular cells , suggesting that this process may be related , at least in part , to the appearance of thyroid dysfunction during IFNs therapy . Positive_regulation CXCR1 TNF 10090924 600282 Metalloproteinases are involved in lipopolysaccharide- and *mediated* regulation of [CXCR1] and CXCR2 chemokine receptor expression . Positive_regulation CXCR2 TNF 10090924 600283 Metalloproteinases are involved in lipopolysaccharide- and *mediated* regulation of CXCR1 and [CXCR2] chemokine receptor expression . Positive_regulation CXCR2 TNF 18462836 2185382 These data suggest that [CXCR2] overexpression in peripheral T cells is intracerebral microglial *dependent* and TNF-alpha primes T cells transendothelial migration in Alzheimer 's diseases . Positive_regulation CXCR2 TNF 19864593 2160669 We conclude that [CXCR2] is required for RV-induced neutrophilic airway inflammation and that neutrophil release is *required* for airway hyperresponsiveness . Positive_regulation CXCR3 CAPN8 24135023 2868008 We further show that pericytes are also able to induce regression of newly formed microvascular cords through [CXCR3] *activation* of . Positive_regulation CXCR3 TLR7 16847431 1600259 ligands and cytokines *induce* [CXCR3] ligands in endothelial cells : enhanced CXCL9 in autoimmune arthritis . Positive_regulation CXCR3 TNF 23623383 2790375 We showed that acute stimulation of murine microvascular endothelial cells expressing the tumor necrosis factor receptors TNFR1 and TNFR2 with the soluble cytokine *led* to [CXCR3] chemokine generation . Positive_regulation CXCR4 ANGPT1 22558265 2591218 Overexpression of *resulted* in a significant increase in [CXCR-4/SDF-1a] expression and promoted CD133 ( + ) /c-kit ( + ) , CD133 ( + ) /CXCR-4 ( + ) and CD133 ( + ) /SDF-1a ( + ) cell recruitment into ischemic hearts . Positive_regulation CXCR4 CLU 20813109 2341756 *induces* [CXCR4] expression and migration of cardiac progenitor cells . Positive_regulation CXCR4 EPHB2 18481208 1840569 The differential requirement for ROS in the *activation* of , JNK , p38 , and Akt by the BCR , CD40 , and [CXCR4] likely reflects the multiplicity of upstream activators for each of these kinases , only some of which may be regulated in a redox dependent manner . Positive_regulation CXCR4 EPHB2 20102637 2213035 Chondrosarcoma cell invasion is increased by hypoxia induced expression of [CXCR4] and MMP1 and is *mediated* by HIF-1a and . Positive_regulation CXCR4 F2R 16141404 1475542 activation also *increased* [CXCR4] expression on EPC and induced SDF-1 secretion , leading to autocrine stimulation . Positive_regulation CXCR4 FOXO1 15184910 1273842 First , we demonstrated in both short-term and long-term systems that *upregulates* expression of the gene encoding the chemokine receptor [CXCR4] . Positive_regulation CXCR4 HBEGF 21482691 2434547 Both amphiregulin and *enhanced* the proliferation , migration , and functional [CXCR4] expression in highly CXCR4 expressing gastric cancer NUGC4 cells . Positive_regulation CXCR4 IL1B 11160334 781698 The peak of [CXCR4] expression in *response* to TNF-alpha and was 8 and 4 h , respectively . Positive_regulation CXCR4 ITGAL 15235585 1281982 Invasion and metastasis of these cells requires *activation* of the integrin by the [CXCR4] chemokine receptor . Positive_regulation CXCR4 PTGER2 20705717 2363459 Subsequently , PGE2via *induces* expression of [CXCR4] . Positive_regulation CXCR4 PTGER2 20705717 2363461 Using an in vitro model system of Ishikawa endometrial epithelial cells stably expressing PTGER2 and human first trimester decidua explants , we demonstrate that [CXCR4] expression is *regulated* by via the epidermal growth factor receptor (EGFR)-phosphatidylinositol-3-kinase (PI3K)-extracellular signal regulated kinase ( ERK1/2 ) pathway . Positive_regulation CXCR4 RGS2 24973550 2952522 Overexpression of in HEK293 cells , a human embryonic kidney cell line , and RAW264.7 cells , a monocyte/macrophage line , *inhibited* the AngII induced activation of ERK and increase of [CXCR4] expression . Positive_regulation CXCR4 SELL 12609846 1085249 stimulation *enhances* functional expression of surface [CXCR4] in lymphocytes : implications for cellular activation during adhesion and migration . Positive_regulation CXCR4 SELL 12609846 1085253 Taken together , mediated signals specifically *enhance* [CXCR4] expression and function , suggesting a novel mechanism for the modulation of lymphocyte activation during cell adhesion and transmigration . Positive_regulation CXCR4 SELL 21460863 2448199 Sulfatide , one of the native ligands for L-selectin , induced the increase of surface CXCR4 expression on isolated circulating neutrophils , suggesting that the activation of may be *involved* in the increase in surface [CXCR4] . Positive_regulation CXCR4 TNF 10195234 561031 Although treatment of PBMCs with interferon-alpha (IFN-alpha) and IFN-gamma led to a significant repression of CXCR4 gene expression , interleukin-1 beta (IL-1 beta) , IL-6 , and *had* no significant effect on [CXCR4] gene expression in PBMCs . Positive_regulation CXCR4 TNF 10679062 668606 Stimulation of mature DCs with TGF-beta 1 also *enhanced* TNF-alpha induced down-regulation of the expressions of CCR-1 , CCR-3 , CCR-5 , CCR-6 , and [CXCR-4] , and chemotaxis to their respective ligands , while this stimulation suppressed induced expression of CCR-7 and chemotactic migratory ability to MIP-3 beta . Positive_regulation CXCR4 TNF 10820276 694427 The surface expression of [CXCR4] in eosinophils was *up-regulated* by IFN-gamma , , and TGF-beta while it was down-regulated by IL-4 and eosinophil directed hemopoietins such as IL-5 . Positive_regulation CXCR4 TNF 10877490 708906 However , while has a protective role in antiviral resistance of activated CD4+ T cells to R5-tropic viruses , it *enhances* [CXCR4] expression of CD4+ T cells and mediates increased susceptibility to infection with X4-tropic strains of HIV and recombinant SIVs . Positive_regulation CXCR4 TNF 11145843 780338 drives HIV-1 replication in U937 cell clones and *upregulates* [CXCR4] . Positive_regulation CXCR4 TNF 11146046 780345 *mediated* decrease of CXCR4 mRNA accumulation resulted in decreased [CXCR4] protein expression . Positive_regulation CXCR4 TNF 11160334 781697 The peak of [CXCR4] expression in *response* to and IL-1beta was 8 and 4 h , respectively . Positive_regulation CXCR4 TNF 12555203 1051615 Expression of chemokines and their receptors in human and simian astrocytes : evidence for a central *role* of and IFN gamma in [CXCR4] and CCR5 modulation . Positive_regulation CXCR4 TNF 14550764 1152792 Cyclic AMP and *regulate* [CXCR4] gene expression in Schwann cells . Positive_regulation CXCR4 TNF 14579271 1156726 Tauhe down-modulation of [CXCR4] surface expression in *response* to and IFN-gamma was fully reversible after cytokine removal . Positive_regulation CXCR4 TNF 19391039 2094941 , transforming growth factor-beta1 ( TGF-beta1 ) , and vascular endothelial growth factor ( VEGF ) *enhanced* [CXCR4] expression in RPMI8226 cells . Positive_regulation CXCR4 TNF 21127499 2407665 In addition , significantly *enhanced* expression of the chemokine receptor [CXCR4] ( CXC motive chemokine receptor 4 ) , which facilitated the chemotactic invasiveness of hMSCs toward stromal cell derived factor 1 (SDF-1) alpha . Positive_regulation CXCR4 TNF 22158049 2668170 Blocking p75 by short-hairpin RNA in cultured LLCs led to increases in *mediated* apoptosis , as well as decreases in the constitutive and TNF mediated expression of angiogenic growth factors ( VEGF , HGF , PLGF ) , and SDF-1a receptor [CXCR4] . Positive_regulation CXCR4 TNFSF10 15990565 1429559 The increase in death receptor expression and acquisition of TRAIL sensitivity *requires* the chemokine coreceptor [CXCR4] but not CCR5 or the CD4 receptor . Positive_regulation CXCR4 TNFSF10 20137126 2208053 Moreover , *up-regulated* the expression level of adherent molecule [CXCR4] in RPMI8226 cells significantly . Positive_regulation CXCR4 TNFSF10 20137126 2208054 It is concluded that *up-regulated* the expression level of adherent molecule [CXCR4] in RPMI8226 cells significantly , and induced the apoptosis of RPMI8226 cells . Positive_regulation CXCR5 MAP2K6 18006504 1860209 Ectopic overexpression of RAF *enhanced* [BLR1] expression in response to RA , whereas inhibition of RAF or by inhibitors or knockdown of RAF by short interfering RNA diminished RA-induced BLR1 expression and attenuated differentiation and growth arrest . Positive_regulation CXCR6 TNF 19438592 2078061 Moreover , we elucidated that and cytosine-guanine dinucleotide ( CpG ) DNA ( Toll-like receptor-9 ligand ) treatment *enhanced* [CXCR6] expression by HGF . Positive_regulation CYBA TNF 12807699 1185278 p22phox antisense oligonucleotide prevented the *induced* effect on [p22phox] , p47phox , O2-* , and permeability . Positive_regulation CYBA TNF 18309110 1897009 Inhibitors of AP-1 significantly diminished the Ang II or *stimulated* [p22(phox)] promoter activity and protein level . Positive_regulation CYBA TNF 18331441 1904680 However , only AlphaTau1 ( 10 ( -8 ) mol/L ) but not AT2 ( 10 ( -5 ) mol/L ) receptor blocker significantly decreased *induced* [p22phox] protein levels . Positive_regulation CYBB IL1B 15784009 1425010 *augmented* the expression of the catalytic gp91 subunit of NADPH oxidase , [gp91phox] , as well as inducible NO synthase in ATDC5 cells . Positive_regulation CYBB SPHK1 23933064 2845041 Furthermore , deficiency *attenuated* hyperoxia induced accumulation of IL-6 in bronchoalveolar lavage fluids and [NADPH oxidase (NOX) 2] and NOX4 protein expression in lung tissue . Positive_regulation CYBB TLR7 15994412 1446973 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for tumor necrosis factor ( TNF-alpha ) , interleukin 6 , nitric oxide synthase-II ( iNOS ) , and [NADPH oxidase 2 (Nox2)] . Positive_regulation CYBB TLR7 23386616 2754984 In this study , we investigated the *role* of in [Nox2] expression in spinal cord microglia after peripheral nerve injury . Positive_regulation CYBB TNF 11241298 792004 Our results indicate that in monocytes the IFN-gamma- and induced expression of gp91phox and p22phox , but not p47phox , *requires* the binding of PU.1 to [gp91phox] promoter . Positive_regulation CYBB TNF 12016268 942390 Stimulation of HPAE cells with *resulted* in the phosphorylation of p47(phox) and its association with [gp91(phox)] . Positive_regulation CYBB TNF 12016268 942393 PKCzeta was shown to colocalize with p47(phox) , and inhibition of PKCzeta activation prevented the interaction of p47(phox) with [gp91(phox)] *induced* by . Positive_regulation CYBB TNF 15326075 1290593 LPS , , and IL-1alpha all *stimulated* the formation of O2*- and expression of [gp91(phox)] in both PAVSMCs and PAECs , an effect inhibited by NADPH oxidase inhibitors , diphenyleneiodonium , and apocynin . Positive_regulation CYBB TNF 16181054 1461880 Thus , IFN-gamma and *induced* equivalent [gp91-phox] gene expression in THP-1 cells compared with CM or PBM but did not bring about equivalent NADPH oxidase activity . Positive_regulation CYBB TNF 17197441 1702258 Additionally , *induced* the association of CD11b/CD18 with the NADPH oxidase subunit [Nox2] ( gp91(phox) ) and phosphorylation of p47(phox) , indicating the CD11b/CD18 dependence of NADPH oxidase activation . Positive_regulation CYBB TNF 17537988 1784151 Pharmacological inhibitors of NF-kappaB activation blocked induced *up-regulation* of NCF1 , NCF2 , and [CYBB] message , which correlated with a reduction in expression of the corresponding oxidase proteins and decreased O2*- production . Positive_regulation CYBB TNF 18846041 1988563 Both 100 nM NaHS and 1 nM ACS6 completely inhibited [gp91(phox)] expression *induced* by . Positive_regulation CYBB TNF 22685265 2633482 Consistent with this , rotenone , an antagonist of mitochondrial complex I , inhibited *induction* of Msx2 and [Nox2] , whereas pyruvate , an anapleurotic mitochondrial metabolic substrate , enhanced induction . Positive_regulation CYBB TNF 23691105 2785672 Moreover , brain targeted blockade significantly *reduced* Ang II-induced [NOX-2] and NOX-4 mRNA and protein expression in the PVN . Positive_regulation CYBB TNF 2496143 109647 and immune interferon synergistically *induce* [cytochrome b-245 heavy-chain] gene expression and nicotinamide-adenine dinucleotide phosphate hydrogenase oxidase in human leukemic myeloid cells . Positive_regulation CYCS ALOX5 12660222 1074124 Creating conditions similar to those that occur during exposure of cells to microgravity induces apoptosis in human lymphocytes by <5-lipoxygenase> *mediated* mitochondrial uncoupling and [cytochrome c] release . Positive_regulation CYCS ALOX5 12694304 1080717 The present study was designed to test the possibility that <5-lipoxygenase> activation might *cause* mitochondrial damage and [cytochrome c] release , ultimately leading PBMC to apoptosis . Positive_regulation CYCS CAPN8 12721303 1106516 Consistent with the actions of calpains upstream of p53 and the proximal nature of p53 death signaling , inhibition *inhibited* [cytochrome c] release and DEVD-AFC cleavage activity . Positive_regulation CYCS CAPN8 12917435 1150973 Results showed that 3NP induced death of striatal neurons was preceded by [cytochrome c] redistribution , transient caspase-9 processing , and *activation* of , whereas levels of the active/processed form of caspase-3 remained low and were even reduced as compared with control animals . Positive_regulation CYCS CAPN8 15899566 1458517 Immunohistochemistry and Western blot showed that prolonged hypothermia suppressed [cytochrome c] release from mitochondria to cytosol and *activation* of both caspase-3 and in cortex , hippocampus , thalamus and striatum throughout the experiment . Positive_regulation CYCS CAPN8 16988947 1633742 Predominantly apoptosis occurred following exposure of SH-SY5Y cells to 50 microM APG , 50 microM EGC , 50 microM EGCG and 100 microM GST for 24 hr. Apoptosis was associated with increases in intracellular free [ Ca ( 2+ ) ] and Bax : Bcl-2 ratio , mitochondrial release of [cytochrome c] and *activation* of caspase-9 , and caspase-3 . Positive_regulation CYCS CAPN8 17039248 1708906 The Hq mutation did not inhibit HI-induced mitochondrial release of [cytochrome c] or *activation* of and caspase-3 . Positive_regulation CYCS CAPN8 17647244 1793550 Other events in apoptosis included overexpression of Bax , down-regulation of Bcl-2 and some BIRC proteins , mitochondrial release of [cytochrome c] and Smac into the cytosol , and *activation* of , caspase-9 , and caspase-3 . Positive_regulation CYCS CAPN8 17987264 1859885 The events of apoptosis included increase in expression of Bax , down regulation of Bcl-2 and baculoviral inhibitor-of-apoptosis protein (IAP) repeat containing ( BIRC ) proteins , mitochondrial release of [cytochrome c] and Smac into the cytosol , increase in intracellular free [ Ca ( 2+ ) ] , and *activation* of , caspase-9 , and caspase-3 . Positive_regulation CYCS CAPN8 18214855 1883923 Remarkably , *mediated* release of [cytochrome c] and cell death was significantly compromised in the Bid knockdown cells . Positive_regulation CYCS CAPN8 18602901 1947199 Besides , apoptosis was associated with alterations in expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins resulting in an increase in Bax : Bcl-2 ratio , mitochondrial release of [cytochrome c] and Smac , downregulation of selective baculoviral inhibitor-of-apoptosis repeat containing ( BIRC ) molecules , an increase in intracellular free [ Ca2+ ] , and *activation* of and caspase-3 . Positive_regulation CYCS CAPN8 19894226 2188723 Other events in apoptosis included overexpression of Bax , loss of DeltaPsi ( m ) , mitochondrial release of [cytochrome c] and Smac into the cytosol , down-regulation of baculoviral inhibitor-of-apoptosis repeat containing proteins , and *activation* of , caspase-9 , and caspase-3 . Positive_regulation CYCS CAPN8 22555453 2637504 activation within the mitochondria could *trigger* the release of [cytochrome c] and other pro-apoptotic factors , whereas in lysosomes it might be essential for tissue remodeling by releasing cathepsins into the cytosol . Positive_regulation CYCS EPHB2 16053510 1438678 These findings indicate that HIF-1alpha prevents apoptotic cell death through two mechanisms , including inhibition of [cytochrome c] release and *activation* of Akt and . Positive_regulation CYCS EPHB2 16214385 1501155 Taken together , these results indicate that [cytochrome c] release , and the *activation* of and caspase-3 in the final apoptosis pathway are all relevant factors in echinomycin induced apoptosis . Positive_regulation CYCS EPHB2 20046096 2200677 expression *results* in mitochondrial depolarization and translocation of [cytochrome c] from the mitochondria to the cytosol . Positive_regulation CYCS EPHB2 24102522 2852481 Subsequent studies indicated that was the upstream effector of p53 , and this ERK-p53 pathway *mediated* release of [cytochrome c] and up-regulation of Bax/Bcl-2 ratio . Positive_regulation CYCS FAS 10066378 593571 This suggests that an upstream caspase such as caspase-8 is required for the *mediated* release of mitochondrial [cytochrome c] . Positive_regulation CYCS FAS 10364155 620384 Both p53 and signaling have been implicated in c-Myc induced apoptosis but neither was *required* for c-Myc induced [cytochrome c] release . Positive_regulation CYCS FAS 10647997 662009 By contrast , stimulation alone *resulted* in neither [cytochrome c] release nor caspase 9 activation at 3 h , and the increase in the DEVD cleavage activity and apoptosis became evident at later time points . Positive_regulation CYCS FAS 10706558 673188 In conclusion , in vivo stimulation *causes* caspase activation , mitochondrial permeability transition ( decreasing the membrane potential and increasing basal respiration ) , mitochondrial matrix expansion ( as shown by matrix herniation ) , outer mitochondrial membrane rupture , and [cytochrome c] release . Positive_regulation CYCS FAS 10958671 724903 Of note , crBAP31 expressing cells also resisted *mediated* release of [cytochrome c] from mitochondria , and the mitochondrial electrochemical potential was only partly reduced . Positive_regulation CYCS FAS 11059759 746283 Furthermore , IFN-gamma sensitized MCF-7 and MDA-MB231 cells to mediated activation of caspase-8 , *induction* of [cytochrome c] release from mitochondria , and processing of caspase-9 . Positive_regulation CYCS FAS 11454065 837126 However , NO did not interrupt *induced* caspase-8 cleavage or subsequent [cytochrome c] release into the cytosol in rheumatoid synovial cells . Positive_regulation CYCS FAS 11521188 852425 *induced* mitochondrial [cytochrome c] release and processing of caspases 3 , 7 , 8 and 9 in LN-18 cells in the absence of an inhibitor of protein synthesis , cycloheximide ( CHX ) . Positive_regulation CYCS FAS 11536010 854839 induced caspase 3-like activity , [cytochrome c] release and cleavage of caspases 3 , 8 , 9 and poly ( ADP-ribose ) polymerase ( PARP ) *increase* substantially after cotreatment with CD95L and C2-ceramide compared with CD95L treatment alone . Positive_regulation CYCS FAS 12605597 1079490 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block and etoposide *induced* caspase activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and [cytochrome c] release . Positive_regulation CYCS FAS 12605685 1062796 Recently , we reported that the caspase-resistant BAP31 inhibited *mediated* apoptotic membrane fragmentation and the release of [cytochrome c] from mitochondria in KB epithelial cells ( Nguyen M. , Breckenridge G. , Ducret A & Shore G. ( 2000 ) Mol. Cell . Positive_regulation CYCS FAS 18485587 1939120 Furthermore , 2'-nitroflavone decreased the expression of the anti-apoptotic Bcl-XL protein , *induced* the release of [cytochrome C] to cytosol and increased the levels of and Fas-L . Positive_regulation CYCS FAS 19676052 2208936 Molecular studies reveal that XIAP inhibitors enhance *induced* activation of caspases , loss of mitochondrial membrane potential and [cytochrome c] release in a caspase dependent manner . Positive_regulation CYCS FAS 23207769 2705379 Apoptosis was associated with loss of mitochondrial membrane potential , enhancement of mitochondrial [cytochrome c] and apoptosis inducing factor ( AIF ) release , elevation of the Bax/Bcl-2 ratio , *activation* of caspase-9 , -3 but not caspase-8 and , and degradation of poly ( ADP-ribose ) polymerase ( PARP ) . Positive_regulation CYCS GRIK2 19449206 2136070 As result , the inhibition of JNK activation caused by diminishes the phosphorylation of the transcription factor c-Jun , down-regulates FasL expression and *attenuates* bax translocation , release of [cytochrome c] and the activation of caspase-3 . Positive_regulation CYCS IFI27 18330707 1886397 *enhanced* etoposide induced [cytochrome c] release , Bax activation and loss of mitochondrial membrane potential . Positive_regulation CYCS IL1B 12091394 984418 The data are consistent with the idea that activation of p38 plays a significant role in inducing the changes described since induced *activation* of [cytochrome c] translocation and caspase-3 activation in cortical tissue in vitro were reversed by the p38 inhibitor SB203580 . Positive_regulation CYCS IL1B 17678971 1777412 In conclusion , we report the original observation that neuroprotection exerted by 17beta-E ( 2 ) in a rat model of transient focal brain ischemia is accompanied by reduced [cytochrome c] translocation to the cytosol and *involves* early modulation of production . Positive_regulation CYCS MAP2K6 16013042 1447419 Cisplatin induced an increase in Bax expression , mitochondrial membrane depolarization , mitochondrial [cytochrome c] release and caspase-3 activation , and these changes were *prevented* by the inhibitor . Positive_regulation CYCS MMP28 16776320 1496703 Mitochondrial , delta ( phi ) m , may control the permeability of the outer membrane and *regulate* [cytochrome c] release . Positive_regulation CYCS MMP28 22490579 2583342 with ATP production , and respiratory function *restored* , [cytochrome c] release and apoptosis inhibited , and oxidative stress reduced . Positive_regulation CYCS MMP28 23370352 2739101 In addition , tanshinone IIA significantly reduced mitochondrial , *mediated* [cytochrome c] release from mitochondria and activated caspase-3 and 9 , indicating mitochondria dependent apoptosis by tanshinone IIA . Positive_regulation CYCS MMP7 16776320 1496718 Mitochondrial , delta ( phi ) m , may control the permeability of the outer membrane and *regulate* [cytochrome c] release . Positive_regulation CYCS MMP7 22490579 2583357 with ATP production , and respiratory function *restored* , [cytochrome c] release and apoptosis inhibited , and oxidative stress reduced . Positive_regulation CYCS MMP7 23370352 2739116 In addition , tanshinone IIA significantly reduced mitochondrial , *mediated* [cytochrome c] release from mitochondria and activated caspase-3 and 9 , indicating mitochondria dependent apoptosis by tanshinone IIA . Positive_regulation CYCS TNF 10090946 600317 The vinblastine-resistant T-lymphoblastic leukemic cell line CEM/VLB100 has increased sensitivity to *induced* [cytochrome c] release , mitochondrial respiratory inhibition , and consequently apoptosis , compared with parental CEM cells . Positive_regulation CYCS TNF 10090946 600318 An increase in Bcl-2 levels was observed in CEM mitochondria , which showed resistance to *induced* [cytochrome c] release . Positive_regulation CYCS TNF 10617670 657172 However , downstream events differed , since but not ActD/TNF-alpha treatment *caused* mitochondrial [cytochrome c] release . Positive_regulation CYCS TNF 10773886 686445 [Cytochrome c] release was *induced* by treatment in both cell lines , but caspase-9 was not activated . Positive_regulation CYCS TNF 10777606 686914 *induced* [cytochrome c] release from mitochondria was also inhibited by cAMP or cGMP , reinforcing our conclusion that cyclic nucleotides interfere with the early signaling events of TNFalpha mediated apoptosis . Positive_regulation CYCS TNF 10846176 715221 Subsequently , both the decrease in Bcl-2 protein levels and the mitochondrial release of [cytochrome c] in *response* to were largely prevented by exogenous NO . Positive_regulation CYCS TNF 10854232 704238 [Cytochrome c-dependent] *activation* of caspase-3 by requires induction of the mitochondrial permeability transition . Positive_regulation CYCS TNF 11003621 734720 Treatment of hepatocytes with interleukin 1beta (IL-1beta) plus interferon gamma (IFN-gamma) , which induced iNOS expression and NO production , suppressed *induced* Bid cleavage and mitochondrial [cytochrome c] release . Positive_regulation CYCS TNF 11067865 747004 Consistent with these observations , the ability of to *induce* mitochondrial release of [cytochrome c] , caspase activation , and apoptosis of isolated hepatocytes was markedly diminished in cells from CatB ( -/- ) mice . Positive_regulation CYCS TNF 11095643 755309 In mechanistic terms , bFGF synergistically increased *induced* mitochondrial permeability transition , the release of [cytochrome c] from mitochondria to the cytosol , and upregulation of the proapoptotic protein Bak and significantly enhanced activation of caspase-8 protease activity . Positive_regulation CYCS TNF 11102441 810397 CsA blocked the *induced* release of pro-caspase 8 but not [cytochrome c] . Positive_regulation CYCS TNF 11576536 865155 Using human myelogenous leukemia ML-1a , its respiration-deficient and reconstituted cells , we demonstrated that respiratory function is essential for *induced* [cytochrome c] release . Positive_regulation CYCS TNF 11720092 883925 The modulating effects of crocin on the expression of Bcl-2 family proteins led to a marked reduction of a *induced* release of [cytochrome c] from the mitochondria . Positive_regulation CYCS TNF 11952418 930548 In the present study it was shown that apoptosis and release of [cytochrome c] *induced* by staurosporine or by in HeLa cells were not affected by inhibitors of respiration ( rotenone , myxothiazol , antimycin A ) or by uncouplers ( CCCP , DNP ) that decrease the membrane potential at the inner mitochondrial membrane . Positive_regulation CYCS TNF 12149248 985235 Activation of c-Myc promoted *induced* release of [cytochrome c] from mitochondria to the cytosol because of the inhibition of NF-kappaB . Positive_regulation CYCS TNF 12169276 973772 *induced* cleavage of the proapoptotic protein Bid and release of mitochondrial [cytochrome c] . Positive_regulation CYCS TNF 12444550 1017535 In the present study , it is shown that release of [cytochrome c] and apoptosis *induced* by in HeLa cells can be inhibited by ( i ) overexpression of an oncoprotein Bcl-2 , ( ii ) Cyclosporin A , an inhibitor of the mitochondrial permeability transition pore (PTP) or ( iii ) oligomycin , an inhibitor of H+- ATP-synthase . Positive_regulation CYCS TNF 15117824 1258504 Moreover , specific knockdown of Trx2 in EC increases *induced* [cytochrome c] release and cell death without increase in JNK activation , Bid cleavage , and Bax translocation . Positive_regulation CYCS TNF 15131591 1279550 In cells possessing wild-type p53 , stimulated ceramide formation via the activation of both neutral and acid sphingomyelinases ( SMases ) , accompanied by superoxide anion ( O2-* ) production , and *induced* mitochondrial depolarization and [cytochrome c] release , whereas p53-deficient cells were partially resistant to TNF-alpha and lacked O2-* generation and neutral SMase activation . Positive_regulation CYCS TNF 15452110 1341982 These mutant cells exhibited a defect in *induced* caspase activation , Bid cleavage , and release of [cytochrome c] . Positive_regulation CYCS TNF 18347986 1887021 Additionally , the combined and Bis-IX treatment *caused* cleavages of Bid and procaspase-9 , as well as [cytochrome c] release . Positive_regulation CYCS TNF 19130237 2025290 Additionally , the combined and NaBt treatment *caused* cleavage of Bid and caspase-9 activation , as well as [cytochrome c] release from mitochondria . Positive_regulation CYCS TNF 19246452 2062628 CLN2-deficient cells exhibited a defect in *induced* Bid cleavage , release of [cytochrome c] , and caspase-9 and -3 activation . Positive_regulation CYCS TNF 19710104 2168131 However , PC supplementation prevented the *induced* DNA fragmentation , [cytochrome-c] release and caspase-3 activity in control and CD hepatocytes . Positive_regulation CYCS TNF 19752374 2135285 MPCs cocultured with cardiomyocytes inhibited changes in cardiomyocyte mitochondrial membrane potential and [cytochrome c] release *induced* by . Positive_regulation CYCS TNF 20136500 2287345 Since pan-caspase inhibitor z-VAD-fmk abolished the TNF-alpha induced mitochondrial changes , z-DEVD-fmk , an inhibitor of caspase-3 had no effect , suggesting that *induced* mitochondrial changes or [cytochrome c] and Smac release requires caspase-8 but not caspase-3 activation . Positive_regulation CYCS TNF 9774651 539882 Cyclosporin A ( CsA ) , an inhibitor of the MPT , blocked *mediated* apoptosis and [cytochrome c] release . Positive_regulation CYCS TNF 9824162 549094 Inhibition of mitochondrial respiratory chain complex I by *results* in [cytochrome c] release , membrane permeability transition , and apoptosis . Positive_regulation CYCS TNF 9824162 549096 This hypothesis is supported by the following observations : ( 1 ) and rotenone *induced* MPT and [cytochrome c] release ; Positive_regulation CYCS TNFSF10 10760520 683613 Thus , TRAIL engages a death pathway that is at least partially routed via the mitochondria , but in contrast with other stimuli that engage this pathway , *induced* [cytochrome c] release is not regulated by Bcl-2 . Positive_regulation CYCS TNFSF10 11067917 747133 Overexpression of B cell lymphoma gene 2 (Bcl-2) inhibited *induced* release of [cytochrome c] , changes in MMP , and apoptosis . Positive_regulation CYCS TNFSF10 11234890 789706 In HL-60/Bcr-Abl and K562 versus HL-60/neo cells , *caused* less cytosolic accumulation of [cytochrome c] and the processing of caspase-9 and -3 . Positive_regulation CYCS TNFSF10 11313719 805566 MAPK activation was involved in the mechanism of PKC mediated inhibition of *induced* [cytochrome c] release from mitochondria . Positive_regulation CYCS TNFSF10 11355877 815461 Bax translocation is not essential for *induced* [cytochrome c] release and DeltaPsim collapse in the Type I cells . Positive_regulation CYCS TNFSF10 11420695 830695 Bcl-2 also abrogated *induced* [cytochrome c] release and dissipation of Delta Psi ( m ) . Positive_regulation CYCS TNFSF10 11992615 938776 In the presence of wortmannin *induced* activation of caspase-2 , -3 , -7 , -8 , and -9 , as well as dissipation of mitochondrial transmembrane potential and release of [cyto-chrome c] from mitochondria into the cytosol . Positive_regulation CYCS TNFSF10 12196516 997851 We found that receptor could *induce* [cytochrome c (Cyt c)] release from mitochondria in cells that failed to respond to CD95 . Positive_regulation CYCS TNFSF10 12430140 1015176 This study suggests that the combination of Act D-induced down-regulation of XIAP ( Signal I ) and *induced* release of [cytochrome c] ( Signal II ) leads to the reversal of resistance to Apo2L/TRAIL mediated apoptosis in the tumor cells . Positive_regulation CYCS TNFSF10 12481428 1024293 Whereas *induced* the release of [cytochrome c] and endogenous Smac/DIABLO in the CL-1 tumor cells , the cytosolic levels of both molecules were not sufficient to induce apoptosis . Positive_regulation CYCS TNFSF10 12670926 1076227 *induced* [cytochrome c] release and apoptosis in wild-type , Bid ( -/- ) , Bax ( -/- ) , or Bak ( -/- ) MEFs , but not in Bax ( -/- ) Bak ( -/- ) double knockout ( DKO ) MEFs . Positive_regulation CYCS TNFSF10 15137068 1246133 Besides influencing decoy receptors , low-dose UV-light plus also synergistically *promoted* [cytochrome c] and Smac release from mitochondria . Positive_regulation CYCS TNFSF10 15252138 1271533 Knockdown of PKCeta augmented *induced* dissipation of the mitochondrial transmembrane potential and release of [cytochrome c] from mitochondria into the cytosol , indicating that PKCeta acts upstream of mitochondria . Positive_regulation CYCS TNFSF10 15369772 1297219 at 500 ng/ml *induced* significant DNA fragmentation , activation of caspase-8 and 3 , the processing of a proapoptotic BID , and mitochondrial release of [cytochrome c] in HL-60/Vect cells , whereas no such events were observed in the HL-60/FAK cells . Positive_regulation CYCS TNFSF10 15475369 1319208 Instead , in the presence of DcR3 , engagement *resulted* in an increased activation of caspase-8 , an elevated cleavage of Bid , and enhanced release of Smac and [cytochrome c] from mitochondria to cytosol compared with TRAIL alone . Positive_regulation CYCS TNFSF10 15607733 1357001 This compound increased *induced* mitochondrial [cytochrome c] release and poly ( ADP-ribose ) polymerase cleavage . Positive_regulation CYCS TNFSF10 15623604 1349132 Bcl-2 inhibited *induced* Bax translocation , cytosolic release of [cytochrome c] and Smac/DIABLO , and the downstream cleavage of XIAP and DFF45 . Positive_regulation CYCS TNFSF10 16339562 1491663 Blockage of apoptosis by E2 seems to be related to inhibition of *induced* [cytochrome c] release from the mitochondria . Positive_regulation CYCS TNFSF10 16362335 1504671 *induced* activation of caspase-3 , cleavage of Bid and poly-ADP-ribose polymerase , release of [cytochrome c] , and DNA fragmentation were blocked either by a pan-caspase inhibitor ( zVAD-fmk ) or a CB inhibitor ( CA074Me ) , consistent with the involvement of TRAIL as well as CB in cell death . Positive_regulation CYCS TNFSF10 18393775 1893517 Recombinant obtained using an original method *stimulates* the release of [cytochrome c] from mitochondria into the cytoplasm and apoptosis in HeLa carcinoma cells . Positive_regulation CYCS TNFSF10 19036706 2035194 Analysis of signaling pathways reveals that XIAP inhibitors enhance *induced* activation of caspases , loss of mitochondrial membrane potential , and [cytochrome c] release in a caspase dependent manner , indicating that they promote a caspase dependent feedback mitochondrial amplification loop . Positive_regulation CYCS TNFSF10 19065652 2024069 Analysis of signaling pathways reveals that NF-kappaB inhibition prevents TRAIL triggered up-regulation of Mcl-1 , promoting *induced* [cytochrome c] release and activation of caspases . Positive_regulation CYCS TNFSF10 22589394 2625148 Stable expression of DARPP-32 in MKN-28 cells enhanced cell survival and suppressed *induced* [cytochrome c] release and activation of caspase-8 , -9 , and -3 . Positive_regulation CYLD PDE4B 23575688 2768173 Moreover , negatively *regulates* [CYLD] via specific activation of JNK2 but not JNK1 . Positive_regulation CYLD TNF 18497946 1917525 The expression of [CYLD] and NF-kappaB mRNAs in HSG cells was *increased* by . Positive_regulation CYLD TNF 19800320 2153884 In cultured human tubular epithelial HK-2 cells , *up-regulated* [CYLD] expression . Positive_regulation CYP11A1 PGC 21108604 2350729 Additionally , *stimulates* the expression of Cyp11b2 ( aldosterone synthase gene ) , Cyp11b1 ( steroid 11ß-hydroxylase gene ) and [P450scc] ( cholesterol side-chain cleavage enzyme ) , and the synthesis of aldosterone in adrenal-cortex derived Y-1 cells . Positive_regulation CYP11B1 NR2F1 22172629 2543117 Although overexpression *increased* [CYP11B1] and CYP11B2 promoter activation , its effect was not mediated through the common Ad5 element . Positive_regulation CYP11B1 PGC 21108604 2350730 Additionally , *stimulates* the expression of Cyp11b2 ( aldosterone synthase gene ) , [Cyp11b1] ( steroid 11ß-hydroxylase gene ) and P450scc ( cholesterol side-chain cleavage enzyme ) , and the synthesis of aldosterone in adrenal-cortex derived Y-1 cells . Positive_regulation CYP11B2 EPHB2 16527843 1561727 The specific inhibitor of activation , U0126 , *suppressed* the activation of [CYP11B2] transcription induced by BMP-6 without affecting Smad phosphorylation and Tlx2-Luc activity . Positive_regulation CYP11B2 NR2F1 22172629 2543118 Although overexpression *increased* CYP11B1 and [CYP11B2] promoter activation , its effect was not mediated through the common Ad5 element . Positive_regulation CYP11B2 PGC 21108604 2350731 Additionally , *stimulates* the expression of [Cyp11b2] ( aldosterone synthase gene ) , Cyp11b1 ( steroid 11ß-hydroxylase gene ) and P450scc ( cholesterol side-chain cleavage enzyme ) , and the synthesis of aldosterone in adrenal-cortex derived Y-1 cells . Positive_regulation CYP11B2 PGC 21108604 2350732 Knockdown of endogenous SF-1 by siRNA ( small interfering RNA ) abolished the *induction* of LHß and [Cyp11b2] gene expression in aT3-1 and Y-1 cells respectively . Positive_regulation CYP17A1 MAMLD1 21559465 2429666 The results , in conjunction with the previous data , imply that *enhances* [Cyp17a1] expression primarily in Leydig cells and permit to produce a sufficient amount of testosterone for male sex development , independently of the Hes3 related non-canonical Notch signaling . Positive_regulation CYP17A1 TNF 21600230 2454178 Both ILs augmented TNF-a- and LIF induced STAR and [CYP17A1] mRNA *accumulation* , and induced cortisol production ( P < 0.05 for all ) . Positive_regulation CYP17A1 TNF 7628389 316417 PMA , a known activator of PKC , and *had* a similar inhibitory effect on P450c17 expression , testosterone production , and [Cyp17-CAT] activity . Positive_regulation CYP19A1 CCND1 16322267 1487905 [Aromatase] overexpression also *induced* the expression of , proliferating cell nuclear antigen , and the HPV oncogenes , E6 and E7 . Positive_regulation CYP19A1 IL1B 10715546 676438 TGF-beta1 increased *induced* [aromatase] activity in osteoblast-like cells , while it inhibited activity in skin fibroblasts . Positive_regulation CYP19A1 IL1B 11850208 893498 PD98059 ( 100 microM ) reduced *induced* [aromatase] activity in human osteoblast-like cells by more than 90 % , whereas 50 % of the aromatase mRNA concentration was retained compared with the control incubated with DEX+IL-1beta . Positive_regulation CYP19A1 IL1B 1646737 157917 Neither IL-1 alpha nor *had* any effect on basal [aromatase] activity . Positive_regulation CYP19A1 IL1B 17504902 1772683 Metformin suppresses *induced* IL-8 production , [aromatase] activation , and proliferation of endometriotic stromal cells . Positive_regulation CYP19A1 IL1B 17504902 1772685 Metformin dose-dependently suppressed *induced* IL-8 production , cAMP induced mRNA expression and [aromatase] activity , and 5-bromo-2'-deoxyuridine incorporation in ESCs . Positive_regulation CYP19A1 IL1B 8782659 380464 While indomethacin had no effect on *induction* of [aromatase] activity by and TPA , dexamethasone exhibited a temporally biphasic action . Positive_regulation CYP19A1 IL1B 8782659 380465 Dexamethasone alone stimulated aromatase activity and demonstrated a permissive action on [aromatase] *stimulation* by and TPA . Positive_regulation CYP19A1 IL1B 8782659 380466 However , pre-treatment of cells with dexamethasone prevented subsequent *induction* of [aromatase] activity by and TPA . Positive_regulation CYP19A1 IL1B 8782659 380467 We conclude that the cyclooxygenase pathway does not play a mediatory role during the inhibition of cell growth and the *induction* of [aromatase] activity by and TPA . Positive_regulation CYP19A1 PGC 24654751 2942824 *dependent* changes in [aromatase] expression in primary cultured stromal cells ( SCs ) were identified using luciferase and enzymatic assays , exon I-specific RT-PCR , and real-time PCR . Positive_regulation CYP19A1 PGC 24654751 2942826 overexpression *enhanced* [aromatase] promoter activity ( P < .01 ) , mRNA expression ( P < .05 ) , and enzymatic activity ( P < .01 ) in SCs from OE , but not in SCs from EE or NE . Positive_regulation CYP19A1 PTGER2 17614108 1774768 PGE ( 2 ) receptor , EP(1) , and EP(4) were *involved* in the up-regulation of [aromatase] activity in response to PGE ( 2 ) in a Dex dependent manner . Positive_regulation CYP19A1 SLCO2A1 21212407 2386309 The *regulates* adipogenesis and [aromatase] transcription . Positive_regulation CYP19A1 SLCO2A1 21212407 2386311 The main objective of this study was to determine whether *regulates* [CYP19] transcription . Positive_regulation CYP19A1 SLCO2A1 21212407 2386314 Silencing of in preadipocytes increased PGE ( 2 ) levels in the extracellular medium , thereby stimulating the cAMP ? PKA pathway *resulting* in enhanced interaction between pCREB , p300 , and the [CYP19] I.3/II promoter . Positive_regulation CYP19A1 TNF 10405348 629356 In this study , we have examined the ability of paclitaxel or 2-meOE2 to antagonise *stimulated* [aromatase] activity in stromal fibroblasts derived from normal or malignant breast tissues . Positive_regulation CYP19A1 TNF 10405348 629357 Paclitaxel inhibited basal and *stimulated* [aromatase] activities by 88 % and 91 % respectively . Positive_regulation CYP19A1 TNF 10405348 629358 The 16alpha hydroxylated derivative of 2-meoE2 and 2-meOE3 , which does not bind to microtubules , was less effective at inhibiting *stimulated* [aromatase] activity . Positive_regulation CYP19A1 TNF 10731102 579499 PGE2 , and IL-6 plus its soluble receptor (IL-6sR) all *increased* [aromatase] activity in these cells . Positive_regulation CYP19A1 TNF 11879566 919193 The activities of the [aromatase] , estradiol 17beta-hydroxysteroid dehydrogenase and estrone sulfatase are all *increased* by IL-6 and . Positive_regulation CYP19A1 TNF 15862962 1401046 2-MeOEMATE reduced basal aromatase activity in TFs by 87 % and completely abrogated the ability of PGE ( 2 ) , IL-6 plus SR or to *stimulate* [aromatase] activity in these fibroblasts . Positive_regulation CYP19A1 TNF 1671798 152664 Although basic fibroblast growth factor ( 1-100 ng/ml ) , acidic fibroblast growth factor ( 1 ng/ml ) , epidermal growth factor ( 1 ng/ml ) , platelet derived growth factor ( 1 ng/ml ) , ( 1 ng/ml ) , and transforming growth factor-beta 1 ( 1 ng/ml ) have no *effect* on basal [aromatase] activity in human skin fibroblasts , all of these growth factors inhibited the ability of dibutyryladenosine 3',5'-cyclic monophosphate to stimulate aromatase activity . Positive_regulation CYP19A1 TNF 19555998 2117098 treatment *induced* [aromatase] expression in cervical cancer cells . Positive_regulation CYP19A1 TNF 19809499 2148588 In addition , COMT over expression or treatment with 2ME reduced the expression of hypoxia-inducible factor -1alpha ( HIF-1 alpha ) and the basal level as well as *induced* [aromatase] ( CYP19 ) expression . Positive_regulation CYP19A1 TNF 20186112 2216091 Potential target areas which may be attractive alternatives to current therapies are also reviewed and include [aromatase] *inhibitors* , angiogenesis disruptors and inhibitors . Positive_regulation CYP19A1 TNF 21663483 2500044 Suppression of *induced* nuclear factor ?B activation and [aromatase] activity by capsaicin and its analog capsazepine . Positive_regulation CYP19A1 TNF 22169755 2549169 In breast adipose fibroblasts , increased production may *induce* the distal [aromatase] promoter , whereas increased local PGE ( 2 ) production may induce the proximal promoter region . Positive_regulation CYP19A1 TNF 3132919 94250 ( 10 ng/ml ) also *inhibited* the ability of TGF beta ( 1 ng/ml ) to enhance [aromatase] activity and increase progesterone synthesis . Positive_regulation CYP19A1 TNF 7895904 289875 ( 2.5-10.0 ng/ml ) , in the presence of stripped fetal calf serum and dexamethasone , significantly *stimulated* fibroblast [aromatase] activity in a dose dependent manner . Positive_regulation CYP19A1 TNF 8923461 397258 *stimulates* [aromatase] gene expression in human adipose stromal cells through use of an activating protein-1 binding site upstream of promoter 1.4 . Positive_regulation CYP19A1 TNF 9389492 467109 Previously we have shown that type 1 cytokines as well as *stimulate* [aromatase] activity of adipose stromal cells in the presence of dexamethasone . Positive_regulation CYP1A1 ARSA 22209714 2549748 The levels of [CYP 1A1] a phase-I enzyme was *increased* by in both cell lines . Positive_regulation CYP1A1 ARSG 10484072 643921 The [CYP1A1] activity *increased* continuously up to 72 hr , where ASG showed an induction efficiency in the same range as for the positive control ( 1 microM ICZ ) after 24 hr , whereas the CYP1A1 protein level , measured by Western blot analysis , was maximally induced after 24 hr . significantly inhibited CYP1A1 activity in whole cells at concentrations above 1 microM . Positive_regulation CYP1A1 EPHB2 15272135 1302469 Inhibition of by chemical compounds and ablation of JNK *caused* significant decreases in [CYP1A1] induction by TCDD . Positive_regulation CYP1A1 IL1B 9299508 453713 Nuclear runoff analysis showed that transcription of [CYP1A1] was significantly *increased* by TCDD with no effect on CYP1B1 , uPA or . Positive_regulation CYP1A1 PLAU 9299508 453714 Nuclear runoff analysis showed that transcription of [CYP1A1] was significantly *increased* by TCDD with no effect on CYP1B1 , or IL-1beta . Positive_regulation CYP1A1 TNF 19570565 2111204 The organic fraction was examined for PAH content , direct mutagenicity , [CYP1A1] *induction* , and cytotoxicity and release in RAW264.7 macrophages . Positive_regulation CYP1B1 TNF 10403529 629026 The inflammatory cytokine *enhanced* the [Cyp1B1] gene expression in HSCs , either when administered alone or in addition to DMBA , while TGFbeta1 did not affect Cyp1B1 expression , even after DMBA induction . Positive_regulation CYP1B1 TNF 17557910 1778598 In contrast , significantly *enhanced* induction of [CYP1B1] at both mRNA and protein levels , by a mechanism , which was independent of nuclear factor-kappaB activation . Positive_regulation CYP1B1 TNF 18336843 1881656 *enhanced* induction of [CYP1B1] , while it simultaneously suppressed the BaP induced CYP1A1 expression . Positive_regulation CYP24A1 CALCA 14765994 1207497 The findings have been extrapolated to the in vivo situation where we suggest that *induction* of renal [CYP24] by could be important under hypercalcemic conditions thus contributing to the lowering of circulating 1,25 ( OH ) 2D3 levels . Positive_regulation CYP24A1 CEBPB 17257825 1710455 We reported that is a major transcriptional *activator* of [24(OH)ase] that cooperates with CBP/p300 in regulating VDR mediated 24(OH)ase transcription . Positive_regulation CYP24A1 CYP27B1 17254772 1710350 RNAi mediated silencing of abolishes 1,25 ( OH ) 2D3 synthesis and *reduces* osteocalcin and [CYP24] mRNA expression in human osteosarcoma (HOS) cells . Positive_regulation CYP24A1 ETS1 19097033 2024472 ERK5 mediated phosphorylation of the transcription factor *enhanced* 1,25 ( OH ) ( 2 ) D ( 3 ) -mediated [CYP24] gene transcription in proliferating but not differentiated Caco-2 cells due to reduced levels of ERK5 and Ets-1 ( total and phosphoprotein levels ) in differentiated cells . Positive_regulation CYP24A1 ETS1 24926821 2952209 Because ETS factors can cooperate with VDR to induce rat CYP24A1 , we tested whether TMPRSS2 : would *cause* aberrant induction of human [CYP24A1] limiting the activity of VDR . Positive_regulation CYP24A1 ETS2 24926821 2952210 Because ETS factors can cooperate with VDR to induce rat CYP24A1 , we tested whether TMPRSS2 : would *cause* aberrant induction of human [CYP24A1] limiting the activity of VDR . Positive_regulation CYP24A1 FGF23 22739976 2691604 The *dependent* increase in [Cyp24a1] mRNA expression in the mouse kidneys was consistent with the possibility that FGF23 induces vitamin D catabolism . Positive_regulation CYP24A1 GC 19667147 2119395 In this study , the effects of MART-10 and 1alpha,25 ( OH ) 2D3 on proliferation , vitamin D receptor transactivation , ( DBP ) binding , CYP24A1 ( 24-OHase ) substrate hydroxylation kinetics , and *induction* of [CYP24A1] gene expression were compared in an androgen dependent prostate cancer cell model , LNCaP . Positive_regulation CYP24A1 GRAP2 19015318 1991776 As shown by the use of chemical inhibitors , dominant negative mutants and small interfering RNA , RhoA-ROCK , and activation is *necessary* for the induction of CDH1/E-cadherin , [CYP24] , and other genes and of an adhesive phenotype by 1,25 ( OH ) ( 2 ) D ( 3 ) . Positive_regulation CYP24A1 GUCY2D 17535892 1751585 Further , *induces* [CYP24-hydroxylase] mRNA gene expression in the kidney of vitamin D-deficient rats . Positive_regulation CYP24A1 MAPK1 19015318 1991778 As shown by the use of chemical inhibitors , dominant negative mutants and small interfering RNA , RhoA-ROCK , and activation is *necessary* for the induction of CDH1/E-cadherin , [CYP24] , and other genes and of an adhesive phenotype by 1,25 ( OH ) ( 2 ) D ( 3 ) . Positive_regulation CYP24A1 MAPK10 19015318 1991779 As shown by the use of chemical inhibitors , dominant negative mutants and small interfering RNA , RhoA-ROCK , and activation is *necessary* for the induction of CDH1/E-cadherin , [CYP24] , and other genes and of an adhesive phenotype by 1,25 ( OH ) ( 2 ) D ( 3 ) . Positive_regulation CYP24A1 MAPK11 19015318 1991780 As shown by the use of chemical inhibitors , dominant negative mutants and small interfering RNA , RhoA-ROCK , and activation is *necessary* for the induction of CDH1/E-cadherin , [CYP24] , and other genes and of an adhesive phenotype by 1,25 ( OH ) ( 2 ) D ( 3 ) . Positive_regulation CYP24A1 MAPK12 19015318 1991781 As shown by the use of chemical inhibitors , dominant negative mutants and small interfering RNA , RhoA-ROCK , and activation is *necessary* for the induction of CDH1/E-cadherin , [CYP24] , and other genes and of an adhesive phenotype by 1,25 ( OH ) ( 2 ) D ( 3 ) . Positive_regulation CYP24A1 MAPK13 19015318 1991782 As shown by the use of chemical inhibitors , dominant negative mutants and small interfering RNA , RhoA-ROCK , and activation is *necessary* for the induction of CDH1/E-cadherin , [CYP24] , and other genes and of an adhesive phenotype by 1,25 ( OH ) ( 2 ) D ( 3 ) . Positive_regulation CYP24A1 MAPK14 19015318 1991783 As shown by the use of chemical inhibitors , dominant negative mutants and small interfering RNA , RhoA-ROCK , and activation is *necessary* for the induction of CDH1/E-cadherin , [CYP24] , and other genes and of an adhesive phenotype by 1,25 ( OH ) ( 2 ) D ( 3 ) . Positive_regulation CYP24A1 MAPK15 19015318 1991775 As shown by the use of chemical inhibitors , dominant negative mutants and small interfering RNA , RhoA-ROCK , and activation is *necessary* for the induction of CDH1/E-cadherin , [CYP24] , and other genes and of an adhesive phenotype by 1,25 ( OH ) ( 2 ) D ( 3 ) . Positive_regulation CYP24A1 MAPK3 15836435 1432541 Using HEK-293T cells ( human embryonic kidney 293T cells ) , we reported that 1,25D induction of [CYP24] *requires* JNK ( c-Jun N-terminal kinase ) but not the ( extracellular-signal regulated kinase 1/2 ) . Positive_regulation CYP24A1 MAPK3 19015318 1991784 As shown by the use of chemical inhibitors , dominant negative mutants and small interfering RNA , RhoA-ROCK , and activation is *necessary* for the induction of CDH1/E-cadherin , [CYP24] , and other genes and of an adhesive phenotype by 1,25 ( OH ) ( 2 ) D ( 3 ) . Positive_regulation CYP24A1 MAPK3 19097033 2024474 This suggests signaling *enhances* 1,25 ( OH ) ( 2 ) D ( 3 ) effects on the [CYP24] promoter by MED1 mediated events . Positive_regulation CYP24A1 MAPK4 19015318 1991785 As shown by the use of chemical inhibitors , dominant negative mutants and small interfering RNA , RhoA-ROCK , and activation is *necessary* for the induction of CDH1/E-cadherin , [CYP24] , and other genes and of an adhesive phenotype by 1,25 ( OH ) ( 2 ) D ( 3 ) . Positive_regulation CYP24A1 MAPK6 19015318 1991786 As shown by the use of chemical inhibitors , dominant negative mutants and small interfering RNA , RhoA-ROCK , and activation is *necessary* for the induction of CDH1/E-cadherin , [CYP24] , and other genes and of an adhesive phenotype by 1,25 ( OH ) ( 2 ) D ( 3 ) . Positive_regulation CYP24A1 MAPK7 19015318 1991787 As shown by the use of chemical inhibitors , dominant negative mutants and small interfering RNA , RhoA-ROCK , and activation is *necessary* for the induction of CDH1/E-cadherin , [CYP24] , and other genes and of an adhesive phenotype by 1,25 ( OH ) ( 2 ) D ( 3 ) . Positive_regulation CYP24A1 MAPK8 19015318 1991788 As shown by the use of chemical inhibitors , dominant negative mutants and small interfering RNA , RhoA-ROCK , and activation is *necessary* for the induction of CDH1/E-cadherin , [CYP24] , and other genes and of an adhesive phenotype by 1,25 ( OH ) ( 2 ) D ( 3 ) . Positive_regulation CYP24A1 MAPK9 19015318 1991789 As shown by the use of chemical inhibitors , dominant negative mutants and small interfering RNA , RhoA-ROCK , and activation is *necessary* for the induction of CDH1/E-cadherin , [CYP24] , and other genes and of an adhesive phenotype by 1,25 ( OH ) ( 2 ) D ( 3 ) . Positive_regulation CYP24A1 MYLIP 19570947 2136712 Human [CYP24] catalyzing the inactivation of calcitriol is post-transcriptionally *regulated* by . Positive_regulation CYP24A1 MYLIP 19570947 2136714 We investigated whether [CYP24] is *regulated* by . Positive_regulation CYP24A1 MYLIP 19570947 2136716 These results suggested that human [CYP24] is *regulated* by . Positive_regulation CYP24A1 MYLIP 19570947 2136718 In conclusion , this study clearly demonstrates that post-transcriptionally *regulates* the [CYP24] , which serves as a possible mechanism for the high CYP24 expression in cancer tissues . Positive_regulation CYP24A1 NR1I2 16691293 1563739 and vitamin D receptor crosstalk *mediates* [CYP24] expression and drug induced osteomalacia . Positive_regulation CYP24A1 NR1I2 16691293 1563740 A recent report suggests that activation of also *enhances* the expression of [CYP24] , providing a new molecular mechanism of drug induced osteomalacia . Positive_regulation CYP24A1 NR1I2 16691293 1563741 However , here we showed that activation of did not *induce* [CYP24] expression in vitro and in vivo , nor did it transactivate the CYP24 promoter . Positive_regulation CYP24A1 PRDX2 21115105 2377583 Transactivation of [CYP24] promoter by VD3 was enhanced in the *presence* of both and VPA . Positive_regulation CYP24A1 PTH 12504896 1034113 [CYP24] promoter activity in transfected cells was *increased* by both 1,25 ( OH ) ( 2 ) D and , but there was no interaction between the two . Positive_regulation CYP24A1 PTH 15601867 1356765 *potentiated* the induction of C/EBPbeta and [24(OH)ase] expression in response to 1,25 ( OH ) ( 2 ) D ( 3 ) in osteoblastic cells . Positive_regulation CYP24A1 PTH 7999096 283572 Rat 1-34 ( 250 nM ) in the presence of 1,25 ( OH ) 2D further *increased* [P450cc24] mRNA levels 7-10 fold after 3 hours . Positive_regulation CYP24A1 PTH 9681485 521186 alone *had* no effect on [CYP24] mRNA levels , and 1,25 ( OH ) 2D alone produced only a modest increase . Positive_regulation CYP24A1 PTH 9681485 521188 However , 1,25 ( OH ) 2D and together synergistically *increased* [CYP24] mRNA levels 3-fold compared with 1,25 ( OH ) 2D alone . Positive_regulation CYP24A1 PTH 9681485 521189 in the presence of 1,25 ( OH ) 2D *increased* [CYP24] gene transcription as shown by nuclear run-on studies and by activation of a CYP24 promoter-reporter construct after transfection . Positive_regulation CYP24A1 RHOA 19015318 1991777 As shown by the use of chemical inhibitors , dominant negative mutants and small interfering RNA , , and p38MAPK-MSK1 activation is *necessary* for the induction of CDH1/E-cadherin , [CYP24] , and other genes and of an adhesive phenotype by 1,25 ( OH ) ( 2 ) D ( 3 ) . Positive_regulation CYP24A1 ROCK1 19015318 1991772 As shown by the use of chemical inhibitors , dominant negative mutants and small interfering RNA , , and p38MAPK-MSK1 activation is *necessary* for the induction of CDH1/E-cadherin , [CYP24] , and other genes and of an adhesive phenotype by 1,25 ( OH ) ( 2 ) D ( 3 ) . Positive_regulation CYP24A1 ROCK2 19015318 1991773 As shown by the use of chemical inhibitors , dominant negative mutants and small interfering RNA , , and p38MAPK-MSK1 activation is *necessary* for the induction of CDH1/E-cadherin , [CYP24] , and other genes and of an adhesive phenotype by 1,25 ( OH ) ( 2 ) D ( 3 ) . Positive_regulation CYP24A1 RPS6KA5 19015318 1991774 As shown by the use of chemical inhibitors , dominant negative mutants and small interfering RNA , RhoA-ROCK , and activation is *necessary* for the induction of CDH1/E-cadherin , [CYP24] , and other genes and of an adhesive phenotype by 1,25 ( OH ) ( 2 ) D ( 3 ) . Positive_regulation CYP24A1 SIL1 19244278 2062604 also *increased* the expression of [CYP24A1] induced by a non-vitamin D VDR ligand , lithocholic acid acetate . Positive_regulation CYP24A1 TMPRSS2 24926821 2952211 In TMPRSS2 : ETS positive VCaP cells , depletion of : ETS substantially *reduced* 1,25D mediated [CYP24A1] induction . Positive_regulation CYP24A1 TNF 19501915 2103007 also significantly inhibited expression of hCG , HSD3B1 and CYP19 genes , and *stimulated* [CYP24A1] gene expression . Positive_regulation CYP24A1 VDR 16691293 1563738 Steroid and xenobiotic receptor and crosstalk *mediates* [CYP24] expression and drug induced osteomalacia . Positive_regulation CYP24A1 VDR 16691293 1563744 Instead , SXR inhibited *mediated* [CYP24] promoter activity , and CYP24 expression was very low in tissues containing high levels of SXR , including the small intestine . Positive_regulation CYP24A1 VDR 17257825 1710454 We reported that C/EBPbeta is a major transcriptional activator of 24(OH)ase that cooperates with CBP/p300 in regulating *mediated* [24(OH)ase] transcription . Positive_regulation CYP24A1 VDR 17257825 1710456 Recently , we found , in addition to p160 coactivators , that SWI/SNF complexes ( that facilitate transcription by remodeling chromatin using the energy of ATP hydrolysis ) are also involved in *mediated* [24(OH)ase] transcription and functionally cooperate with C/EBPbeta in regulating 24(OH)ase . Positive_regulation CYP24A1 VDR 17286279 1771764 Dissociation of growth arrest and [CYP24] *induction* by ligands in mammary tumor cells . Positive_regulation CYP24A1 VDR 18089708 1838051 This was not due to a drug induced cytotoxic effect , reduction in the expression of the vitamin D receptor or inhibition of the *mediated* activation of the mitogen activated protein kinases or [CYP24] promoter activity . Positive_regulation CYP24A1 VDR 19667147 2119394 In this study , the effects of MART-10 and 1alpha,25 ( OH ) 2D3 on proliferation , *transactivation* , vitamin D-binding protein ( DBP ) binding , [CYP24A1] ( 24-OHase ) substrate hydroxylation kinetics , and induction of CYP24A1 gene expression were compared in an androgen dependent prostate cancer cell model , LNCaP . Positive_regulation CYP24A1 VDR 19814732 2159685 These effects were associated with *mediated* expression of cytochrome [CYP24A1] with no effects on ASM apoptosis . Positive_regulation CYP24A1 VDR 20307664 2287541 mRNA expression was detected in all samples and [CYP24A1] mRNA expression was *induced* by 1alpha,25 ( OH ) 2D3 in both concentrations ( but mainly with 100 nM ) . Positive_regulation CYP24A1 VDR 21115105 2377582 Valproic acid augments mediated *induction* of [CYP24] by vitamin D3 : a possible cause of valproic acid induced osteomalacia ? Positive_regulation CYP24A1 VDR 22068926 2534156 It is well known that in the presence of 1,25 ( OH ) 2D3 , binds to VDREs in the promoter region of CYP24 and *initiates* [CYP24] transcription . Positive_regulation CYP24A1 VDR 9165006 432194 Pretreatment of mice with cycloheximide ( 400 microg/g ) , an inhibitor of protein synthesis , potentiated the increase in 24-OHase mRNA abundance , but blocked the increase in 24-OHase activity , induced by 1,25- ( OH ) 2D3 in kidney and duodenum , suggesting that [24-OHase] gene expression may be *regulated* not only by the but also by a short lived repressor protein . Positive_regulation CYP26A1 NR2F1 23018522 2720232 Moreover , analysis of the expression of primary RA response genes indicates that is *involved* in the regulatory modulation of the expression of at least two genes , [CYP26A1] and HoxA1 . Positive_regulation CYP26A1 RARB 16261163 1525712 Similarly , we found that [Cyp26a1] transcription is epigenetically *regulated* by . Positive_regulation CYP26A1 RARB 20231276 2254509 Hoxa1 and [Cyp26a1] transcripts are not expressed , but ( 2 ) transcripts are *induced* by RA in mouse embryonic fibroblasts and Balb/c3T3 cells . Positive_regulation CYP2A PGC 22859313 2687435 Acute but not chronic CYP2A5 induction by phenobarbital required Nrf2 , whereas [CYP2A5] *induction* by dibutyryl-cAMP and was potentiated by Nrf2 knockout . Positive_regulation CYP2C19 ABCG2 24332840 2905165 In LS180 cells , telaprevir strongly induced mRNA expression of ( 4.3-fold at 30 µmol/L ) and weakly *induced* ABCB11 , [CYP2C19] and UGT1A3 . Positive_regulation CYP2C19 FOXA1 10931833 743816 Transcription of a [CYP2C12] promoter-luciferase reporter gene in transfected HepG2 cells was *activated* 15-40-fold by the liver enriched , HNF3 beta , and HNF6 . Positive_regulation CYP2C19 RNASE1 11040044 741872 The use of functional blocking antibodies demonstrates that fibronectin is operating through its alpha(5)beta(1) integrin receptor and genistein , a tyrosine kinase inhibitor , prevents hepatocyte spreading , *induction* , and [CYP2C11] mRNA loss . Positive_regulation CYP2C19 RNASE7 11040044 741880 The use of functional blocking antibodies demonstrates that fibronectin is operating through its alpha(5)beta(1) integrin receptor and genistein , a tyrosine kinase inhibitor , prevents hepatocyte spreading , *induction* , and [CYP2C11] mRNA loss . Positive_regulation CYP2E1 IL1B 12887687 1116932 [Cytochrome P450 2E1 (CYP2E1)] is highly *inducible* in a subset of astrocytes in vivo following ischemic or mechanical injury and in vitro by lipopolysaccharide or . Positive_regulation CYP2E1 IL1B 8913336 395522 We have found that lipopolysaccharide and *stimulate* the expression of catalytically active [CYP2E1] ( but not CYP1A1 or CYP2B ) up to 7-fold in rat brain primary cortical glial cultures . Positive_regulation CYP2E1 NR2F1 15488474 1321164 The pig [CYP2E1] promoter is *activated* by and HNF-1 and is inhibited by androstenone . Positive_regulation CYP2E1 TNF 16175602 1461838 In conclusion , forced overfeeding with a high-fat diet in mice induces obesity , insulin resistance , and SH in the absence of signaling or [Cyp2e1] *induction* . Positive_regulation CYP3A TNF 12814963 1103395 [CYP3A] *induction* by N-hydroxyformamide converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans . Positive_regulation CYP3A4 ABCG2 23428312 2765219 In LS180 cells , rilpivirine *induced* mRNA expression of ABCB1 , [CYP3A4] and UGT1A3 , whereas ABCC1 , ABCC2 , , OATP1B1 and UGT1A9 were not induced . Positive_regulation CYP3A4 EPHB2 15205382 1261258 These results indicate that JNK , but not or p38 , is *required* for the optimal activation of the [CYP3A4] gene induced by 1,25 ( OH ) ( 2 ) D ( 3 ) . Positive_regulation CYP4F11 IL1B 19812349 2184074 Proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha) and , which can activate the AP-1 complex , *induce* [CYP4F11] transcription in HaCaT cells . Positive_regulation CYP7A1 FOXO1 19463968 2128300 This study investigated the *roles* of in the regulation of [cholesterol 7alpha-hydroxylase] ( CYP7A1 ) gene expression in primary human hepatocytes . Positive_regulation CYP7A1 FOXO1 21817852 2495536 However , ectopic expression of *increased* the rat [CYP7A1-] , but mildly reduced human CYP7A1-promoter activities in a dose dependent manner . Positive_regulation CYP7A1 IL1B 15476247 1319411 In addition , *enhanced* CYP7B mRNA and [CYP7B] protein levels in FLS . Positive_regulation CYP7A1 PCSK9 22593575 2619804 Our results indicate that although PPAR? activation increased expression , PPAR? activation *induced* LDLR and [CYP7A1] expression that enhanced LDL cholesterol metabolism . Positive_regulation CYP7A1 TNF 15751070 1379927 Stimulation with *increased* [CYP7B] activity in all cell lines tested . Positive_regulation CYP7A1 TNF 16049268 1447767 Herein , to clarify the *role* of in LN-induced downregulation of [cholesterol 7alpha-hydroxylase] , effects of LN on gene expression of hepatic cholesterol 7alpha-hydroxylase ( Cyp7a1 ) in TNF-alpha-knockout ( KO ) and TNF-alpha-wild-type ( WT ) mice were comparatively examined . Positive_regulation CYP7A1 TNF 16277680 1480501 The aim of this study was to elucidate which signal transduction pathway is involved in the *mediated* induction of [Cyp7b] activity in FLS . Positive_regulation CYP7A1 TNF 16277680 1480502 SN50 and PSI prevented the *induced* increase in [Cyp7b] activity , whereas the mitogen activated protein kinase inhibitors PD98059 and SB203580 had no effect . Positive_regulation CYP7A1 TNF 16855167 1588642 Next , we studied which signal transduction pathway is involved in the *mediated* induction of [Cyp7b] activity in human FLS . Positive_regulation CYR61 CTGF 16856934 1600396 In vitro assessment of their biological activities revealed that [Cyr61] expression *induces* a genetic reprogramming of angiogenic , adhesive and structural proteins while promotes distinctively extracellular matrix accumulation ( i.e. , type I collagen ) which is the principal hallmark of fibrotic diseases . Positive_regulation CYR61 EPHB2 21317023 2403738 inhibitor PD98059 , N-acetyl-L-cysteine , Rho associated protein kinase (ROCK) selective inhibitor Y-27632 and a geranylgeranyltransferase inhibitor *reduced* the arecoline stimulated levels of [Cyr61] protein by ~31 % , 47 % , 65 % and 100 % , respectively . Positive_regulation CYR61 F2R 16510585 1530386 Here , we show that ectopic expression *induces* expression of the angiogenic factor [Cyr61] ( CCN1 ) in breast cancer cells . Positive_regulation CYR61 PTGER2 12724323 1106575 Activation of prostaglandin receptors ( Gs-coupled ) also *up-regulated* [Cyr61] but not CTGF mRNA expression in the isolated cat iris . Positive_regulation CYR61 TNF 18202125 1895358 [CYR61] mRNA expression was further *regulated* by IL-1 , , PGE2 , and PGF2alpha . Positive_regulation CYR61 TNF 19410078 2075256 The study assessed the effect of simvastatin on *induced* synthesis of [Cyr61] and CCL2 in MG-63 human osteoblastic cells . Positive_regulation CYR61 TNF 19410078 2075257 Western blot showed that *stimulated* [Cyr61] synthesis in MG-63 , whereas simvastatin attenuated this effect in a dose dependent manner . Positive_regulation CYR61 TNF 20478458 2263049 In the study we examined the effect of major histocompatibility complex class II transactivator (CIITA) on *induced* [Cyr61] synthesis in U2OS human osteoblastic cells by Western blot analysis . Positive_regulation CYR61 TNF 23239110 2745565 In RASFs , simvastatin suppressed the *induced* production of [CYR-61] and CCL20 . Positive_regulation CYR61 TNF 23611379 2774615 Forced expression of FoxO3a reduced *stimulated* [Cyr61] synthesis . Positive_regulation CYSLTR1 ALOX5 1635053 194302 The validation of the LT hypothesis of disease had to wait for the demonstration of a clinical effect by either a [LTD4 receptor] antagonist or a LT synthesis *inhibitor* ( <5-LO> inhibitor ) . Positive_regulation CYTH2 ARL4D 17804820 1810171 Furthermore , *induced* translocation of [cytohesin-2/ARNO] did not require phosphoinositide 3-kinase activation . Positive_regulation CYTL1 MAP2K6 10442636 635738 This [C17] neuronal cell induced Nf1+/- increase in proliferation was *blocked* by inhibition ( PD98059 ) , suggesting a p21-ras dependent effect . Positive_regulation DAB2IP TNF 12813029 1103100 [AIP1] exists in a closed form through an intramolecular interaction between the N-terminus and the C-terminus , and *induces* unfolding of AIP1 leading to association of AIP1 with ASK1 . Positive_regulation DAB2IP TNF 17389591 1735572 treatment of EC *induces* phosphorylation of [AIP1] at Ser-604 as detected by a phospho-specific antibody , with a similar kinetics to ASK1-JNK/p38 activation . Positive_regulation DAB2IP TNF 17389591 1735573 treatment normally *induces* association of [AIP1] with TRAF2-ASK1 . Positive_regulation DAB2IP TNF 17389591 1735579 We further show that RIP1 ( the Ser/Thr protein kinase receptor interacting protein ) associates with the GAP domain of AIP1 and mediates *induced* [AIP1] phosphorylation at Ser-604 and JNK/p38 activation as demonstrated by both overexpression and small interfering RNA knockdown of RIP1 in EC . Positive_regulation DAB2IP TNF 17389591 1735585 Our results demonstrate that RIP1 mediated AIP1 phosphorylation at the 14-3-3 binding site Ser-604 is essential for *induced* [TRAF2-RIP1-AIP1-ASK1] complex formation and for the activation of ASK1-JNK/p38 apoptotic signaling . Positive_regulation DAB2IP TNF 18292600 1891532 Endogenous AIP1-PP2A complex can be detected in the resting state , and *induces* a complex formation of [AIP1-PP2A] with ASK1 . Positive_regulation DAG1 MMP28 20097170 2212832 *mediated* cleavage of [beta-dystroglycan] in myelin sheath is involved in autoimmune neuritis . Positive_regulation DAG1 MMP7 20097170 2212847 *mediated* cleavage of [beta-dystroglycan] in myelin sheath is involved in autoimmune neuritis . Positive_regulation DAP ITGB2 24295830 2926695 Moreover , IL-32? and [iE-DAP] or MDP *induced* the significant up-regulation of the cell-surface expression of adhesion molecule and ICAM-1 on eosinophils . Positive_regulation DAPK1 AKT1 23071514 2685925 Pro-death activity of violacein is actually carried out by inhibition of calpain and [DAPK1] and *activation* of PKA , and PDK , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation DAPK1 AKT2 23071514 2685926 Pro-death activity of violacein is actually carried out by inhibition of calpain and [DAPK1] and *activation* of PKA , and PDK , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation DAPK1 AKT3 23071514 2685927 Pro-death activity of violacein is actually carried out by inhibition of calpain and [DAPK1] and *activation* of PKA , and PDK , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation DAPK1 CA2 18283219 1919278 *Activation* of endogenous [DAPk] by increasing intracellular also led to increased phosphorylation of MCM3 . Positive_regulation DAPK1 CALM3 12068633 955396 Hamster tumor cell lines obtained with the Rous sarcoma virus and characterized by a high metastatic activity in vitro were transfected with the gene for *dependent* serine-threonine [death associated protein kinase (DAPk)] . Positive_regulation DAPK1 CEBPB 22874566 2710034 Previously , we have shown that transcription factor ( C/EBP-ß ) *regulates* IFNG induced expression of [Dapk1] through a CRE/ATF motif in its enhancer . Positive_regulation DAPK1 CTGF 23175185 2736101 Binding of to EGFR suppresses the phosphorylation of c-Src and extracellular signal regulated kinase but *increases* the expression of [death associated protein kinase] , which leads to anoikis . Positive_regulation DAPK1 DIRAS3 23247805 2818349 however , *promotes* the expression of both p27 ( KIP1 ) and [DAPK1] in SK-MES-1 cells . Positive_regulation DAPK1 EPHB2 15616583 1361982 Phosphorylation of DAPK at Ser 735 by *increases* the catalytic activity of [DAPK] both in vitro and in vivo . Positive_regulation DAPK1 GIF 22465880 2588969 Both TNF-a and significantly *induce* [DAPk1] levels in a time dependent manner . Positive_regulation DAPK1 IFNG 22874566 2710035 Previously , we have shown that transcription factor CEBPB ( C/EBP-ß ) regulates *induced* expression of [Dapk1] through a CRE/ATF motif in its enhancer . Positive_regulation DAPK1 IFNG 22874566 2710048 In this paper we have shown that ATF6 , an ER-resident transcription factor regulates *induced* [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Positive_regulation DAPK1 IL17A 21602493 2441756 Phosphorylation of p300 and [DAPK-1] upon *stimulation* with either IL-32 or was confirmed by immunoblots . Positive_regulation DAPK1 IL32 21602493 2441755 Phosphorylation of p300 and [DAPK-1] upon *stimulation* with either or IL-17 was confirmed by immunoblots . Positive_regulation DAPK1 KLHL20 20389280 2262112 Accordingly , depletion of *diminishes* [DAPK] ubiquitination and degradation . Positive_regulation DAPK1 NFKB1 16551624 1555596 Focusing on human kinases , we have demonstrated that the chaperone recognizes a common surface in the amino-terminal lobe of kinases from diverse families , including two newly identified clients , *inducing* kinase and [death associated protein kinase] , and the oncoprotein HER2/ErbB-2 . Positive_regulation DAPK1 PDK1 23071514 2685928 Pro-death activity of violacein is actually carried out by inhibition of calpain and [DAPK1] and *activation* of PKA , AKT and , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation DAPK1 PDK2 23071514 2685929 Pro-death activity of violacein is actually carried out by inhibition of calpain and [DAPK1] and *activation* of PKA , AKT and , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation DAPK1 PDK3 23071514 2685930 Pro-death activity of violacein is actually carried out by inhibition of calpain and [DAPK1] and *activation* of PKA , AKT and , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation DAPK1 PDK4 23071514 2685931 Pro-death activity of violacein is actually carried out by inhibition of calpain and [DAPK1] and *activation* of PKA , AKT and , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation DAPK1 PDLIM7 21353277 2411400 We observed NF-?B signaling in [DAPK1] *upregulation* by with CTAR deletion mutants failing to induce DAPK1 expression and with Bay11 blocking DAPK1 expression . Positive_regulation DAPK1 PRDX2 16865256 1592752 *increases* the expression of p21 , p53 , [DAPK-1] and the DAPK-2 gene in both OCUM-8 and MKN-74 cells . Positive_regulation DAPK1 PTPRF 17803936 1791086 The tumor suppressor [DAPK] is reciprocally *regulated* by tyrosine kinase Src and phosphatase . Positive_regulation DAPK1 RELA 16551624 1555597 Focusing on human kinases , we have demonstrated that the chaperone recognizes a common surface in the amino-terminal lobe of kinases from diverse families , including two newly identified clients , *inducing* kinase and [death associated protein kinase] , and the oncoprotein HER2/ErbB-2 . Positive_regulation DAPK1 SRC 17803936 1791085 The tumor suppressor [DAPK] is reciprocally *regulated* by tyrosine kinase and phosphatase LAR . Positive_regulation DAPK1 SRC 17803936 1791097 Conversely , phosphorylates DAPK at Y491/492 , which *induces* [DAPK] intra-/intermolecular interaction and inactivation . Positive_regulation DAPK1 TCF12 22874566 2710037 In this paper we have shown that ATF6 , an ER-resident *regulates* IFNG induced [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Positive_regulation DAPK1 TCF15 22874566 2710038 In this paper we have shown that ATF6 , an ER-resident *regulates* IFNG induced [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Positive_regulation DAPK1 TCF19 22874566 2710039 In this paper we have shown that ATF6 , an ER-resident *regulates* IFNG induced [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Positive_regulation DAPK1 TCF20 22874566 2710040 In this paper we have shown that ATF6 , an ER-resident *regulates* IFNG induced [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Positive_regulation DAPK1 TCF21 22874566 2710041 In this paper we have shown that ATF6 , an ER-resident *regulates* IFNG induced [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Positive_regulation DAPK1 TCF23 22874566 2710045 In this paper we have shown that ATF6 , an ER-resident *regulates* IFNG induced [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Positive_regulation DAPK1 TCF24 22874566 2710047 In this paper we have shown that ATF6 , an ER-resident *regulates* IFNG induced [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Positive_regulation DAPK1 TCF25 22874566 2710046 In this paper we have shown that ATF6 , an ER-resident *regulates* IFNG induced [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Positive_regulation DAPK1 TCF3 22874566 2710042 In this paper we have shown that ATF6 , an ER-resident *regulates* IFNG induced [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Positive_regulation DAPK1 TCF4 22874566 2710043 In this paper we have shown that ATF6 , an ER-resident *regulates* IFNG induced [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Positive_regulation DAPK1 TCF7 22874566 2710044 In this paper we have shown that ATF6 , an ER-resident *regulates* IFNG induced [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Positive_regulation DAPK1 TNF 22465880 2588968 Both and INF-? significantly *induce* [DAPk1] levels in a time dependent manner . Positive_regulation DAPK1 TP53 17339337 1720149 Evaluation of these calcium calmodulin kinase superfamily members as candidate Ser ( 20 ) kinases in vivo has shown that only CHK1 or [DAPK-1] can stimulate p53 transactivation and *induce* Ser ( 20 ) phosphorylation of . Positive_regulation DAPK1 TSC2 21134130 2372996 *regulates* the stability of [death associated protein kinase-1 (DAPK)] through a lysosome dependent degradation pathway . Positive_regulation DAPK1 TSC2 21134130 2373008 Finally , we show that [DAPK] is regulated by the lysosome pathway and that lysosome inhibition blocks *mediated* degradation of DAPK . Positive_regulation DAPK1 UNC5B 18582460 1946697 Moreover we show that the interaction of UNC5H2 with the downstream pro-apoptotic serine threonine kinase [DAPk] is *dependent* on both lipid raft localization and palmitoylation . Positive_regulation DAPK2 CTGF 23175185 2736102 Binding of to EGFR suppresses the phosphorylation of c-Src and extracellular signal regulated kinase but *increases* the expression of [death associated protein kinase] , which leads to anoikis . Positive_regulation DAPK2 EPHB2 15616583 1361983 Phosphorylation of DAPK at Ser 735 by *increases* the catalytic activity of [DAPK] both in vitro and in vivo . Positive_regulation DAPK2 UNC5B 18582460 1946698 Moreover we show that the interaction of UNC5H2 with the downstream pro-apoptotic serine threonine kinase [DAPk] is *dependent* on both lipid raft localization and palmitoylation . Positive_regulation DAPK3 CTGF 23175185 2736103 Binding of to EGFR suppresses the phosphorylation of c-Src and extracellular signal regulated kinase but *increases* the expression of [death associated protein kinase] , which leads to anoikis . Positive_regulation DAPK3 DAPK1 18995835 1990126 Here we show that IFN-gamma activates a kinase cascade in which *activates* [zipper interacting protein kinase (ZIPK)] , culminating in L13a phosphorylation on Ser ( 77 ) , L13a release from the ribosome , and translational silencing of GAIT element bearing target mRNAs . Positive_regulation DAPK3 EPHB2 15616583 1361984 Phosphorylation of DAPK at Ser 735 by *increases* the catalytic activity of [DAPK] both in vitro and in vivo . Positive_regulation DAPK3 UNC5B 18582460 1946699 Moreover we show that the interaction of UNC5H2 with the downstream pro-apoptotic serine threonine kinase [DAPk] is *dependent* on both lipid raft localization and palmitoylation . Positive_regulation DAXX FAS 11003656 734763 However , HSP27 blocked *induced* translocation of Daxx from the nucleus to the cytoplasm and Fas induced [Daxx-] and Ask1 dependent apoptosis . Positive_regulation DAXX FAS 11193028 761660 Fas also activates a caspase independent pathway which correlates with *induced* translocation of [Daxx] from the nucleus to the cytoplasm and involves the interaction of Daxx with Fas and Ask1 . Positive_regulation DAXX FAS 12867652 1112077 Although studies by others suggest that the nucleocapsid protein of Puumala virus interacts with the *mediated* apoptosis enhancer [Daxx] at the gene expression level , it was determined that members of the TNF receptor superfamily did not contribute to the apoptosis observed in infected HEK293 cells . Positive_regulation DAXX FAS 9743501 532547 The death receptor can *activate* the Jun NH2-terminal kinase (JNK) pathway through the receptor associated protein [Daxx] . Positive_regulation DAXX FAS 9743501 532549 activation *induced* [Daxx] to interact with ASK1 , which consequently relieved an inhibitory intramolecular interaction between the amino- and carboxyl-termini of ASK1 , activating its kinase activity . Positive_regulation DAXX TLR7 24550390 2928879 The expression of [Daxx] is significantly up-regulated by *stimulation* with ligands LPS and poly ( I:C ) . Positive_regulation DAXX TNF 19789335 2147760 Here , we show that treatment *induces* the accumulation of [Daxx] protein through ASK1 activation by preventing its proteasome dependent degradation . Positive_regulation DBH FOXO1 25353004 2959873 *regulates* [Dbh] expression and the activity of the sympathetic nervous system in vivo . Positive_regulation DCD EPHB2 19014393 2029102 Furthermore , we confirmed that [DCD-1L] could *induce* phosphorylation of p38 and , and noticeably upregulated NF-kappaB activation . Positive_regulation DCN CTGF 21454550 2448151 Finally , we showed that specifically *induced* the synthesis of [decorin] , suggesting a mechanism of autoregulation . Positive_regulation DCN IGFBP1 11934254 927776 Transforming growth factor beta ( TGF-beta ) , [decorin] ( a proteoglycan in the ECM ) , and melanoma cell adhesion molecule ( Mel-CAM ) inhibit , and insulin-like growth factor II (IGF-II) , , and endothelin 1 (ET-1) *stimulate* EVT cell migration/invasion . Positive_regulation DCN IL1B 11532373 854049 *stimulated* [decorin] expression to about 140 % in control fibroblasts while about 110 % in patient fibroblasts . Positive_regulation DCN IL1B 7490271 335481 [decorin] was only slightly *up-regulated* by , while biglycan was markedly down-regulated by IL-1 beta and significantly up-regulated by TGF-beta 1 . Positive_regulation DCN IL1B 9089489 421861 These results suggest that the increased transcription of [decorin] gene by HPLF in the *presence* of is mediated at least in part through the interaction of AP-1 with the decorin gene promoter . Positive_regulation DCN IL1B 9689917 522947 In contrast , *had* a weak inhibitory effect on both [decorin] and biglycan expression . Positive_regulation DCN TNF 22413766 2624380 Furthermore , studies with human testicular peritubular cells isolated from fibrotic testis indicated that significantly *increased* [DCN] production . Positive_regulation DCN TNF 23460644 2776488 Compared with , IFN-? treatment induced significantly more CXCL-10 , and both factors *increased* synthesis of CXCL-10 in the presence of [decorin] . Positive_regulation DCN TNF 9485085 488225 In contrast , *resulted* in a marked increase in [decorin] mRNA levels ( +260 % ) that was not the result of transcriptional regulation . Positive_regulation DCN TNF 9485085 488226 These data demonstrate that 1 ) the expression of the core protein genes encoding the cartilage proteoglycans aggrecan , biglycan , and [decorin] is differentially *regulated* by IFN gamma and ; Positive_regulation DCSTAMP EPHB2 19641137 2124933 Inhibition of and NFATc1 *suppressed* the expression of [DC-STAMP] and led to the fusion inhibition of pOC . Positive_regulation DCT TGM2 25009701 2948422 Meanwhile , gene silencing of *suppressed* dendrite extension and the expressions of TRP-1 and [TRP-2] in a-MSH treated SK-MEL-2 cells . Positive_regulation DCTN3 TNF 11244505 792323 Here , we show that in HeLa cells *induces* expression of [p22PRG1/IEX-1] in an NF-kappaB dependent fashion . Positive_regulation DCTN3 TNF 11244505 792326 Blockade of NF-kappaB activation by various NF-kappaB inhibitors abolished *induced* [p22PRG1/IEX-1] expression and increased the sensitivity to apoptosis induced by TNFalpha , an activating Fas-antibody or the anti-cancer drug etoposide . Positive_regulation DDAH1 IL1B 12574151 1057794 ( 1 to 100 U/mL ) dose-dependently *stimulated* not only iNOS but also [DDAH] expression and enzyme activity , accompanied by an increase in NO metabolite and by a decrease in ADMA content in culture media . Positive_regulation DDAH2 IL1B 12574151 1057795 ( 1 to 100 U/mL ) dose-dependently *stimulated* not only iNOS but also [DDAH] expression and enzyme activity , accompanied by an increase in NO metabolite and by a decrease in ADMA content in culture media . Positive_regulation DDC EPHB2 18215168 1870961 It has been recently reported that robust expression of the [DDC] gene *requires* activation of extracellular signal regulated kinase ( ) in epidermal cells of wounded Drosophila embryos . Positive_regulation DDC MAOA 7874502 287550 Enzyme assays demonstrated that [aromatic L-amino acid decarboxylase] activity was unchanged in the gliotic striatum , but both and MAO-B activities *increased* by 23 % and 21 % , respectively . Positive_regulation DDC TLR7 19625644 2118353 We have investigated the ability of *stimulated* human Langerhans cells ( LC ) , [dermal DCs (dDC)] , and monocyte derived DCs ( moDC ) to affect naive and memory Th17 and Th1 responses . Positive_regulation DDIT3 IL1B 15605392 1402226 treatment *induced* PERK and eIF2-alpha phosphorylation , but not [GADD153] expression or apoptosis . Positive_regulation DDIT3 TNF 17911345 1830183 *induced* rat preadipocyte [CHOP] expression . Positive_regulation DDIT3 TNF 18006442 1860160 The stretch induced [GADD153] is *mediated* by , at least in part , through the JNK and AP-1 pathway . Positive_regulation DDIT3 TNF 22319522 2553779 PTX ( 1 mM ) reduced *induced* activation of GRP78 , p-eIF2 , ATF4 , IRE1a , and [CHOP] in vitro . Positive_regulation DDIT3 TNF 24080827 2847614 Our data therefore revealed a role of ER stress and [ATF4/CHOP] in the ethanol induced inhibition of osteogenesis , and *activation* of signaling by ATF4/CHOP linking ER stress to adipogenic lineage in response to alcohol stimulation . Positive_regulation DDIT3 TNFSF10 18172319 1856012 In addition , As ( 2 ) O ( 3 ) -mediated up-regulation of [CHOP] and DR5 , as well as partial proteolytic processing of procaspase-3 by , was not *induced* in astrocytes . Positive_regulation DDIT3 TNFSF10 24525736 2914819 Overexpression of phosphomimetic eIF2a ( S51D ) enhances *induced* [CHOP] expression , caspase 7 and PARP cleavage and apoptosis . Positive_regulation DDIT3 TNFSF10 24525736 2914832 Moreover , knockdown of growth arrest and DNA damage-inducible protein 34 ( GADD34 ) , which recruits protein phosphatase 1 to dephosphorylate eIF2a , enhances *induced* eIF2a phosphorylation , [CHOP] expression , caspase activation and apoptosis . Positive_regulation DDIT4 MAP2K6 23272222 2709763 In HEK-293 cells , expression of a constitutive active form of *stabilizes* [REDD1] and protects REDD1 from proteasomal degradation mediated by CUL4A-DDB1 ubiquitin ligase complex . Positive_regulation DDR1 IL1B 11606478 883374 The expression level of [DDR1] in PBMC was *increased* further by stimulation with tumor necrosis factor-alpha , , granulocyte-macrophage colony stimulating factor , lipopolysaccharide , or phytohemagglutinin , but not with interferon-gamma . Positive_regulation DDR1 MMP28 16234985 1539209 Inhibition of activity using MMP inhibitor *suppressed* [DDR1a] stimulated cell-invasion . Positive_regulation DDR1 MMP7 16234985 1539224 Inhibition of activity using MMP inhibitor *suppressed* [DDR1a] stimulated cell-invasion . Positive_regulation DDR1 NES 23115280 2721461 The interaction between [NEP] and CRM1 is coordinately *regulated* by both the previously reported ( NES1 ) and now the new NES2 . Positive_regulation DDR1 TNF 11606478 883371 The expression level of [DDR1] in PBMC was *increased* further by stimulation with , interleukin-1beta , granulocyte-macrophage colony stimulating factor , lipopolysaccharide , or phytohemagglutinin , but not with interferon-gamma . Positive_regulation DDR1 TNF 9505146 491284 IL-1 beta , and to a lesser extent , and IL-4 *increased* [NEP] activity and expression , whereas IFN-gamma decreased NEP . Positive_regulation DDR2 TNF 18821853 2034582 HBO induced [DDR2] is *mediated* by and at least in part through the p38 MAPK and Myc pathways . Positive_regulation DDT TNF 18755234 1975293 Further , [DDT] *induced* the significant ( p < 0.05 ) production of and nitric oxide ( NO ) in macrophages and thus contributes inflammatory reactions , cytokine imbalance and immune-dysregulation . Positive_regulation DDX20 SMN2 10369862 621813 In SMA patients , the loss of SMN1 but the presence of *results* in low levels of full-length [SMN] transcript and therefore low SMN protein levels which causes SMA . Positive_regulation DDX20 SMN2 10500148 648041 Moreover , we show that [SMN] , but not mutants found in SMA patients , can form large oligomers and that oligomerization is *required* for high-affinity binding to spliceosomal snRNP Sm proteins . Positive_regulation DDX20 SMN2 10767334 684904 We suggest that the interaction between SMN and [DP103] is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Positive_regulation DDX20 SMN2 10901626 712853 Immunolocalization studies using SMN monoclonal antibody showed that is decreased in cultures grown in low K+ or chemically defined medium with respect to cultures grown in high K+ medium and that an increase of [SMN] can be *induced* by treatment of low K+ cultures with glutamate or N-methyl-D-aspartate . Positive_regulation DDX58 ANKRD1 22328336 2586517 the of ankrd17 is *required* for its interaction with [RIG-I] as well as for its function in regulating the RLR pathway . Positive_regulation DDX58 IL1B 17064399 1637367 We previously reported that *induced* [RIG-I] expression in gingival fibroblasts . Positive_regulation DDX58 OASL 24931123 2946935 Loss of expression *reduced* [RIG-I] signaling and enhanced virus replication in human cells . Positive_regulation DDX58 TNF 17878351 1796913 Our findings support a sequential mechanism whereby *leads* to stabilization of IFN-epsilon mRNA , increased IFN-epsilon synthesis , engagement of type I IFNRs , increased STAT1 expression and phosphorylation , and up-regulation of [RIG-I] expression . Positive_regulation DDX58 TNF 19126414 2031869 RNA interference against interferon (IFN)-beta abolished the *induced* [RIG-I] expression . Positive_regulation DDX58 TNF 19201382 2054178 RIG-I was constitutively expressed in the epithelial cell lines HT-29 , and IFN-gamma and *enhanced* the [RIG-I] expression in a dose dependent manner . Positive_regulation DDX58 TNF 22391244 2566590 In human keratinocytes , [RIG-I] is *induced* by IFN-? and stimulation , and is abundantly expressed in psoriatic keratinocytes of the spinous and basal layers . Positive_regulation DEFA1B TNF 1421280 202109 It was shown that production by human monocytes activated by SAC or PMA was augmented in the presence of HNP-1 concentrations of 10 ( -8 ) -10 ( -9 ) M . [HNP-1] alone *induced* no synthesis of TNF-alpha . Positive_regulation DEFB1 IL1B 12171956 974264 Interestingly , *induction* of [hBD1] gene expression by was only observed in MKN7 cells . Positive_regulation DEFB103B IL1B 11223260 787870 Furthermore , in fetal lung explants and gingival keratinocytes , [HBD-3] mRNA expression was *induced* by . Positive_regulation DEFB103B IL1B 15270856 1276481 Interferon (IFN)-gamma , but not tumour necrosis factor (TNF)-alpha or , *augmented* [hBD-3] mRNA expression . Positive_regulation DEFB103B TNF 15270856 1276479 Interferon (IFN)-gamma , but not or IL-1beta , *augmented* [hBD-3] mRNA expression . Positive_regulation DEFB103B TNF 16101361 1444265 In addition to the published observations ( PMA induces hBD-2 and -4 ; *induces* [hBD-2 and -3] ) , it was found that PMA can upregulate hBD-1 and hBD-3 , whereas TNF-alpha can induce hBD-4 . Positive_regulation DEFB103B TNF 17617590 1769640 This interferes with STAT-1 and NF-kappaB signaling , thereby inhibiting *mediated* induction of HBD-2 and [HBD-3] . Positive_regulation DEFB103B TNF 23499548 2771996 siRNAs targeting c-Jun and STAT3 suppressed visfatin plus *induced* [hBD-3] production . Positive_regulation DEFB104B TNF 16101361 1444259 In addition to the published observations ( PMA *induces* [hBD-2 and -4] ; induces hBD-2 and -3 ) , it was found that PMA can upregulate hBD-1 and hBD-3 , whereas TNF-alpha can induce hBD-4 . Positive_regulation DEFB4A IL1B 19503839 2091976 TLR2/1L induction of was *required* for upregulation of [DEFB4] , but not cathelicidin , whereas VDR activation was required for expression of both antimicrobial genes . Positive_regulation DEFB4A TLR7 19503839 2091969 Here , we report that activation of monocytes *triggers* induction of the [defensin beta 4 gene (DEFB4)] , requiring convergence of the IL-1beta and vitamin D receptor (VDR) pathways . Positive_regulation DEFB4B CD14 10882713 730193 Thus , LPS induction of [hBD2] in hTBE cells *requires* , which may complex with a TLR to ultimately activate NF-kappa B . Positive_regulation DEFB4B CD14 11523142 852891 It has been shown that LPS induced expression of [hBD-2] in human tracheobronchial epithelial cells *requires* , which may complex with Toll-like receptors ( TLRs ) to ultimately activate NF-kappa B . Positive_regulation DEFB4B IL1B 10837369 699394 Mucoid Pseudomonas aeruginosa , TNF-alpha , and , but not IL-6 , *induce* human [beta-defensin-2] in respiratory epithelia . Positive_regulation DEFB4B IL1B 12682256 1077670 Furthermore , and TNF-alpha in the culture supernatants from LPS stimulated monocytic cells *activated* the [hBD-2] promoter in A549 cells . Positive_regulation DEFB4B IL1B 12714616 1083512 and TNFalpha each *stimulated* the expression of [hBD-2] in HCECs and were more effective in combination than alone . Positive_regulation DEFB4B IL1B 12714616 1083513 The NFkappaB inhibitors pyrrolidinedithiocarbamate ( PDTC ; 100 microM ) , caffeic acid phenethyl ester ( CAPE ; 90 microM ) , and MG-132 ( 25 microM ) , blocked *stimulated* expression of [hBD-2] . Positive_regulation DEFB4B IL1B 15240151 1270112 *Up-regulation* of human [beta-defensin 2] by in A549 cells : involvement of PI3K , PKC , p38 MAPK , JNK , and NF-kappaB . Positive_regulation DEFB4B IL1B 15304092 1284500 Inhibition of mediated [hBD-2] *induction* through RA was further confirmed by gene reporter assays and western-blot analysis . Positive_regulation DEFB4B IL1B 16417227 1514516 Pseudomonas aeruginosa- and mediated *induction* of human [beta-defensin-2] in keratinocytes is controlled by NF-kappaB and AP-1 . Positive_regulation DEFB4B IL1B 16417227 1514520 Mutation of all NF-kappaB binding sites together with mutation of the AP-1 binding site completely abolished [hBD-2] promoter *activation* by and PA . Positive_regulation DEFB4B IL1B 16417227 1514521 Treatment with the NF-kappaB inhibitor Helenalin as well as with the c-Jun N-terminal kinase (JNK) inhibitor SP600125 and the p38 mitogen activated protein kinase inhibitor SB 202190 blocked [hBD-2] *induction* by and PA . Positive_regulation DEFB4B IL1B 16417227 1514528 Transcription factor ELISAs indicated that the NF-kappaB heterodimer p50-p65 binds to all three NF-kappaB sites in the [hBD-2] promoter upon *stimulation* of primary keratinocytes with and PA . Positive_regulation DEFB4B IL1B 16641320 1569543 ROFA also inhibited the increase of *induced* human [beta-defensin-2] , a homologue of TAP , in A549 cells . Positive_regulation DEFB4B IL1B 16723032 1589947 markedly *up-regulated* the [hBD-2] promoter activity , and the subsequent DEP exposure increased dose-dependently the expression of hBD-2 and inflammatory cytokine IL-8 at the transcriptional level . Positive_regulation DEFB4B IL1B 17133055 1653244 The effect of hyperosmolality on *induced* [hBD-2] expression was also tested . Positive_regulation DEFB4B IL1B 17390080 1716118 Triptolide suppresses *induced* human [beta-defensin-2] mRNA expression through inhibition of transcriptional activation of NF-kappaB in A549 cells . Positive_regulation DEFB4B IL1B 17645739 1793258 Dexamethasone suppresses *induced* human [beta-defensin 2] mRNA expression : involvement of p38 MAPK , JNK , MKP-1 , and NF-kappaB transcriptional factor in A549 cells . Positive_regulation DEFB4B IL1B 18389480 1899259 IL-12 , IL-23 , and IL-27 enhanced *induced* [hBD-2] secretion and mRNA expression in keratinocytes . Positive_regulation DEFB4B IL1B 18389480 1899288 These results suggest that IL-12 , IL-23 , and IL-27 may enhance *induced* [hBD-2] production in keratinocytes by activating NF-kappaB . Positive_regulation DEFB4B IL1B 18556347 1965885 Although leptin alone was ineffective , it enhanced *induced* [hBD-2] secretion and mRNA expression in keratinocytes . Positive_regulation DEFB4B IL1B 18556347 1965920 or leptin individually *induced* threonine/tyrosine phosphorylation of p38 MAPK , whereas only leptin induced tyrosine phosphorylation of JAK2 , suggesting that leptin may enhance [hBD-2] production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with NF-kappaB , which is activated by IL-1beta . Positive_regulation DEFB4B IL1B 20006664 2199893 Transforming growth factor beta1 ( TGF beta 1 ) and , two well-known tumorigenic inflammatory mediators , *induce* [hBD-2] transcript and peptide expression in HUVECs . Positive_regulation DEFB4B SPHK1 20634980 2292172 is *required* for toll mediated [beta-defensin 2] induction in human oral keratinocytes . Positive_regulation DEFB4B TLR7 15494486 1321852 [Beta-defensin-2] expression is *regulated* by signaling in intestinal epithelial cells . Positive_regulation DEFB4B TNF 10837369 699393 Mucoid Pseudomonas aeruginosa , , and IL-1beta , but not IL-6 , *induce* human [beta-defensin-2] in respiratory epithelia . Positive_regulation DEFB4B TNF 12381917 997401 Coincubation of the cultured cells with IL-1alpha or E. coli promote the strongest hbd-2 induction whereas and LPS *lead* to a weaker or no ( IL-6 ) [hbd-2] induction . Positive_regulation DEFB4B TNF 12682256 1077669 Furthermore , IL-1beta and in the culture supernatants from LPS stimulated monocytic cells *activated* the [hBD-2] promoter in A549 cells . Positive_regulation DEFB4B TNF 12682256 1077672 In addition , a mutation of the NF-kappaB site at -200 ( pkappaB1 site ) completely abolished this IL-1beta- and *induced* [hBD-2] promoter activation , whereas NF-kappaB inhibitors ( MG-132 and helenalin ) strongly suppressed it . Positive_regulation DEFB4B TNF 12714616 1083511 IL-1beta and each *stimulated* the expression of [hBD-2] in HCECs and were more effective in combination than alone . Positive_regulation DEFB4B TNF 16101361 1444262 In addition to the published observations ( PMA induces hBD-2 and -4 ; *induces* [hBD-2] and -3 ) , it was found that PMA can upregulate hBD-1 and hBD-3 , whereas TNF-alpha can induce hBD-4 . Positive_regulation DEFB4B TNF 20003937 2185137 and IL-1 alpha synergistically *increased* [hBD-2] messenger RNA levels , protein expression , and activity . Positive_regulation DEFB4B TNF 22209221 2605445 Pretreatment with nicotine caused a significant 2.5-fold inhibition of *stimulated* [hBD-2] mRNA expression compared to TNF-a alone ( p = 0.004 ) . Positive_regulation DEFB4B TNF 23499548 2771995 siRNAs targeting NF-?B p65 and STAT3 suppressed visfatin plus *induced* [hBD-2] and S100A7 production . Positive_regulation DES CAPN8 17513494 1784023 In a final series of experiments , we demonstrated that cardiac myofilaments exposed to recombinant phosphorylated HSP27 , but not nonphosphorylated HSP27 , had a significant reduction in the *induced* degradation of [desmin] compared with non-HSP27 treated myofilaments . Positive_regulation DES CLU 8170836 255214 [DES] *induced* expression over a longer duration than did castration , suggesting that more than just the decrease of serum testosterone to castrate levels plays a role in the expression of TRPM-2 . Positive_regulation DFFA TNFSF10 15623604 1349134 Bcl-2 inhibited *induced* Bax translocation , cytosolic release of cytochrome c and Smac/DIABLO , and the downstream cleavage of XIAP and [DFF45] . Positive_regulation DFFB CAPN8 12393869 1035875 Cell-permeable inhibitors *prevented* [E-cad] ( 100 ) induction by ionomycin . Positive_regulation DHCR24 EPHB2 21486081 2428411 Hesperetin also stimulated the activation of Akt , , and CREB as well as *induced* brain derived neurotrophic factor , PPAR? coactivator 1a ( PGC-1a ) , and [seladin-1] ( selective Alzheimer 's disease indicator-1 ) via both ER and TrkA in the cells . Positive_regulation DHFR CCND1 7970707 280109 In particular , overexpression *leads* to the activation of the [dihydrofolate reductase (DHFR)] gene promoter . Positive_regulation DHPS SPHK1 19119142 2037005 FTY720 induced up-regulation of [DHS1P] level was *mediated* by , but not SphK2 , as confirmed by experiments using SphK1/2 silencing with small interfering RNA . Positive_regulation DHRS3 TP63 20543567 2360320 Taken together , the results suggest a potential role of the *mediated* [retSDR1] activation in tumor suppression as well as in developmental processes . Positive_regulation DIABLO CAPN8 17647244 1793566 Other events in apoptosis included overexpression of Bax , down-regulation of Bcl-2 and some BIRC proteins , mitochondrial release of cytochrome c and [Smac] into the cytosol , and *activation* of , caspase-9 , and caspase-3 . Positive_regulation DIABLO CAPN8 17987264 1859901 The events of apoptosis included increase in expression of Bax , down regulation of Bcl-2 and baculoviral inhibitor-of-apoptosis protein (IAP) repeat containing ( BIRC ) proteins , mitochondrial release of cytochrome c and [Smac] into the cytosol , increase in intracellular free [ Ca ( 2+ ) ] , and *activation* of , caspase-9 , and caspase-3 . Positive_regulation DIABLO CAPN8 18602901 1947214 Besides , apoptosis was associated with alterations in expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins resulting in an increase in Bax : Bcl-2 ratio , mitochondrial release of cytochrome c and [Smac] , downregulation of selective baculoviral inhibitor-of-apoptosis repeat containing ( BIRC ) molecules , an increase in intracellular free [ Ca2+ ] , and *activation* of and caspase-3 . Positive_regulation DIABLO CAPN8 19894226 2188739 Other events in apoptosis included overexpression of Bax , loss of DeltaPsi ( m ) , mitochondrial release of cytochrome c and [Smac] into the cytosol , down-regulation of baculoviral inhibitor-of-apoptosis repeat containing proteins , and *activation* of , caspase-9 , and caspase-3 . Positive_regulation DIABLO TNF 20136500 2287348 Since pan-caspase inhibitor z-VAD-fmk abolished the TNF-alpha induced mitochondrial changes , z-DEVD-fmk , an inhibitor of caspase-3 had no effect , suggesting that *induced* mitochondrial changes or cytochrome c and [Smac] release requires caspase-8 but not caspase-3 activation . Positive_regulation DIABLO TNFSF10 12481428 1024294 Whereas *induced* the release of cytochrome c and endogenous [Smac/DIABLO] in the CL-1 tumor cells , the cytosolic levels of both molecules were not sufficient to induce apoptosis . Positive_regulation DIABLO TNFSF10 12670926 1076229 Unlike cytochrome c release , *induced* [Smac/DIABLO] release was blocked in Bid ( -/- ) , Bax ( -/- ) , Bak ( -/- ) , or DKO MEFs , suggesting the differential regulation of these mitochondrial proteins during apoptosis . Positive_regulation DIABLO TNFSF10 12771938 1094831 We report that *induced* release of [Smac/DIABLO] appears to be downregulated by concomitant signaling through the MEK Erk1/2 kinase pathway and that this inhibits TRAIL induced apoptosis . Positive_regulation DIABLO TNFSF10 12771938 1094834 These results suggest that Erk1/2 signaling may protect melanoma cells against TRAIL induced apoptosis by inhibiting the relocation of Bax from the cytosol to mitochondria and that this may reduce *mediated* release of [Smac/DIABLO] and induction of apoptosis . Positive_regulation DIABLO TNFSF10 15137068 1246134 Besides influencing decoy receptors , low-dose UV-light plus also synergistically *promoted* cytochrome c and [Smac] release from mitochondria . Positive_regulation DIABLO TNFSF10 15475369 1319209 Instead , in the presence of DcR3 , engagement *resulted* in an increased activation of caspase-8 , an elevated cleavage of Bid , and enhanced release of [Smac] and cytochrome c from mitochondria to cytosol compared with TRAIL alone . Positive_regulation DIABLO TNFSF10 15623604 1349133 Bcl-2 inhibited *induced* Bax translocation , cytosolic release of cytochrome c and [Smac/DIABLO] , and the downstream cleavage of XIAP and DFF45 . Positive_regulation DIABLO TNFSF10 16103097 1444536 Data suggest that in the presence of mitochondrial derived ROS , *induced* mitochondrial release of [Smac/DIABLO] and inactivation of X-linked inhibitor of apoptosis through caspase-9 independent activation of caspase 3 . Positive_regulation DIABLO TNFSF10 17653087 1858045 Our results show that reactive oxygen species are involved in *induced* [Smac/DIABLO] release and in TRAIL triggered apoptosis . Positive_regulation DIANPH ANGPT1 24553436 2928914 We studied the mechanism of *induced* beneficial effects on [diabetic nephropathy] in db/db mice . Positive_regulation DIANPH CTGF 15012739 1183023 The present study was designed to elucidate the *role* of in [diabetic nephropathy (DN)] , immunoglobulin A nephropathy (IgA-N) , membranous nephropathy ( MN ) , and minimal change nephrotic syndrome ( MCNS ) . Positive_regulation DIANPH CTGF 16380465 1553973 Temporal expression profile and distribution pattern indicate a *role* of ( CTGF/CCN-2 ) in [diabetic nephropathy] in mice . Positive_regulation DIANPH CTGF 18235518 1864365 Unraveling the *role* of in [diabetic nephropathy] . Positive_regulation DIANPH CTGF 18632843 1979294 In this study , it was hypothesized that *acts* as an inhibitor of BMP-7 signaling activity in [diabetic nephropathy] . Positive_regulation DIANPH CTGF 23197157 2718263 Moreover , recent studies using antibodies or antisense technologies in animal and early phase clinical trial settings have shown that inhibition of renal expression or action may *prevent* [diabetic nephropathy] . Positive_regulation DIANPH SPON2 22235198 2519497 *Role* of in [diabetic nephropathy] . Positive_regulation DIANPH TNF 12388406 1031473 Furthermore , inhibition of during diabetes may *attenuate* early pathological changes in [diabetic nephropathy] . Positive_regulation DIANPH TNF 17113815 1651166 The *role* of in [diabetic nephropathy] : pathogenic and therapeutic implications . Positive_regulation DIANPH TNFSF10 21251686 2452990 To investigate the *role* of in [diabetic nephropathy] , we measured the serum concentrations of OPG and TRAIL in type 2 diabetes mellitus patients with different stages of nephropathy by enzyme linked immunosorbent assay . Positive_regulation DIO1 TNF 7867596 296473 In TSH deprived FRTL-5 cells , and IFN-gamma *resulted* in a small but dose dependent decrease in [5'D-I] activity . Positive_regulation DISC1 FAS 15660394 1375912 The requirement of EGFR mediated CD95 tyrosine phosphorylation for hyperosmotic and *induced* CD95 membrane targeting and [DISC] formation was also shown in CD95 mutagenesis experiments . Positive_regulation DISC1 FAS 18515572 1951990 First , TFF1 prevents caspase-8 activation at the level of the [DISC] that *involves* receptor in plasma membrane rafts , which in turn decreases the mitochondrial release of cytochrome c . Positive_regulation DISC1 FAS 18820240 2000774 However , the molecular mechanisms whereby Fas mutations and binding might *regulate* Fas mediated [DISC] formation are unknown . Positive_regulation DISC1 FAS 18820240 2000783 The results presented here provide structural evidence for the roles of Fas mutations and CaM/Fas binding in *induced* [DISC] formation . Positive_regulation DISC1 FAS 18948840 2041294 All *led* to a reduced [DISC] formation and diminished initiator caspase activity upon CD95-stimulation , whereas a marked heterogeneity in sensitivity to CD95 induced killing was found . Positive_regulation DISC1 FAS 24204853 2864683 Using Beas2B epithelial cells , we found that in contrast to cav-1 , Flot-2 conferred cytoprotection via preventing *mediated* [death inducing signaling complex (DISC)] formation , subsequently suppressed caspase-8 mediated extrinsic apoptosis . Positive_regulation DISC1 FAS 24702583 2935331 The interaction between CaM and *regulates* Fas mediated [DISC] formation . Positive_regulation DISC1 TNF 17024246 1641548 This study describes a new molecular mechanism implemented by a virus to escape immunosurveillance by selectively targeting TNFR1 endocytosis to prevent *induced* [DISC] formation . Positive_regulation DISC1 TNFSF10 11964312 932782 This was not due to increased assembly and activity of *induced* [DISC] ( death inducing signaling complex ) but dependent on the feedback activity of caspase-3 . Positive_regulation DISC1 TNFSF10 11976344 961598 To explore the signal transduction events in TRAIL triggered apoptosis and its modulation in nontransfected tumor cells , we analyzed *induced* [death inducing signaling complex (DISC)] in TRAIL-sensitive and -resistant glioma cells . Positive_regulation DISC1 TNFSF10 12642685 1030234 the capacity of to *induce* [DISC] formation was completely restored in the presence of DHT . Positive_regulation DISC1 TNFSF10 12660816 1074184 An increased recruitment of Fas associated death domain (FADD) and procaspase-8 to the *induced* [death inducing signaling complex (DISC)] was shown in cells exposed to anticancer drugs . Positive_regulation DISC1 TNFSF10 12761581 1091682 ligation *induced* [DISC] formation in TRAIL-sensitive ( RD , Rh18 , Rh30 ) and TRAIL-resistant RMS ( Rh28 , Rh36 , Rh41 ) , with recruitment of FADD and procaspase-8 . Positive_regulation DISC1 TNFSF10 15388581 1359153 Hsp70 was bound to death receptors 4 and 5 ( DR4 and DR5 ) and inhibited *induced* assembly and activity of the [death inducing signaling complex (DISC)] . Positive_regulation DISC1 TNFSF10 15707589 1372894 To examine molecular mechanisms in cell resistance , we analyzed *induced* [DISC] in TRAIL-sensitive melanoma cells and showed that apoptosis initiating caspase-8 and caspase-10 were recruited to the DISC where they became activated through autocatalytical cleavage , leading to apoptosis through cleavage of downstream substrates such as caspase-3 and DFF45 . Positive_regulation DISC1 TNFSF10 18288942 1872782 For example , small interfering RNAs ( siRNAs ) that specifically knocked down expression of c-FLIP ( L ) in diverse human cancer cell lines , e.g. , lung and cervical cancer cells , augmented *induced* [DISC] recruitment , and thereby enhanced effector caspase stimulation and apoptosis . Positive_regulation DISC1 TNFSF10 19465019 2097334 Based on recent findings that the *dependent* [death inducing signaling complex (DISC)] forms and signals at the plasma membrane without being internalized , we investigated the possibility that agents that prevent endocytosis may stabilize the surface bound DISC and thereby enhance TRAIL dependent signaling . Positive_regulation DISC1 TNFSF10 19465019 2097338 Recruitment of FADD and caspase-8 to the *dependent* [DISC] was diminished in a concentration dependent manner in cells exposed to PAO . Positive_regulation DISC1 TNFSF10 19465019 2097340 PAO inhibited formation of the *dependent* [DISC] and therefore prevented all subsequent apoptotic events . Positive_regulation DISC1 TNFSF10 22456178 2691307 In TRAIL-resistant gastric cancer cells , did not *induce* effective [death inducing signalling complex (DISC)] formation in lipid rafts , accompanied with EGFR translocation into lipid rafts , and activation of EGFR pathway . Positive_regulation DISC1 TNFSF10 23051914 2703106 Furthermore , suppressing autophagy inhibited expression of antiapoptosis factors BIRC2/cIAP1 , BIRC3/cIAP2 , XIAP and CFLAR/c-FLIP and increased the formation of *induced* [death inducing signaling complex (DISC)] . Positive_regulation DISC1 TNFSF10 23070002 2685780 For example , small interfering RNAs ( siRNAs ) that specifically knockdown the expression of c-FLIP ( L ) in diverse human cancer cell lines augmented *induced* [DISC] recruitment and increased the efficacy of chemotherapeutic agents , thereby enhancing effector caspase stimulation and apoptosis . Positive_regulation DISC2 FAS 15660394 1375913 The requirement of EGFR mediated CD95 tyrosine phosphorylation for hyperosmotic and *induced* CD95 membrane targeting and [DISC] formation was also shown in CD95 mutagenesis experiments . Positive_regulation DISC2 FAS 18515572 1951991 First , TFF1 prevents caspase-8 activation at the level of the [DISC] that *involves* receptor in plasma membrane rafts , which in turn decreases the mitochondrial release of cytochrome c . Positive_regulation DISC2 FAS 18820240 2000776 However , the molecular mechanisms whereby Fas mutations and binding might *regulate* Fas mediated [DISC] formation are unknown . Positive_regulation DISC2 FAS 18820240 2000784 The results presented here provide structural evidence for the roles of Fas mutations and CaM/Fas binding in *induced* [DISC] formation . Positive_regulation DISC2 FAS 18948840 2041295 All *led* to a reduced [DISC] formation and diminished initiator caspase activity upon CD95-stimulation , whereas a marked heterogeneity in sensitivity to CD95 induced killing was found . Positive_regulation DISC2 FAS 24204853 2864684 Using Beas2B epithelial cells , we found that in contrast to cav-1 , Flot-2 conferred cytoprotection via preventing *mediated* [death inducing signaling complex (DISC)] formation , subsequently suppressed caspase-8 mediated extrinsic apoptosis . Positive_regulation DISC2 FAS 24702583 2935333 The interaction between CaM and *regulates* Fas mediated [DISC] formation . Positive_regulation DISC2 TNF 17024246 1641549 This study describes a new molecular mechanism implemented by a virus to escape immunosurveillance by selectively targeting TNFR1 endocytosis to prevent *induced* [DISC] formation . Positive_regulation DISC2 TNFSF10 11964312 932783 This was not due to increased assembly and activity of *induced* [DISC] ( death inducing signaling complex ) but dependent on the feedback activity of caspase-3 . Positive_regulation DISC2 TNFSF10 11976344 961599 To explore the signal transduction events in TRAIL triggered apoptosis and its modulation in nontransfected tumor cells , we analyzed *induced* [death inducing signaling complex (DISC)] in TRAIL-sensitive and -resistant glioma cells . Positive_regulation DISC2 TNFSF10 12642685 1030235 the capacity of to *induce* [DISC] formation was completely restored in the presence of DHT . Positive_regulation DISC2 TNFSF10 12660816 1074185 An increased recruitment of Fas associated death domain (FADD) and procaspase-8 to the *induced* [death inducing signaling complex (DISC)] was shown in cells exposed to anticancer drugs . Positive_regulation DISC2 TNFSF10 12761581 1091683 ligation *induced* [DISC] formation in TRAIL-sensitive ( RD , Rh18 , Rh30 ) and TRAIL-resistant RMS ( Rh28 , Rh36 , Rh41 ) , with recruitment of FADD and procaspase-8 . Positive_regulation DISC2 TNFSF10 15388581 1359154 Hsp70 was bound to death receptors 4 and 5 ( DR4 and DR5 ) and inhibited *induced* assembly and activity of the [death inducing signaling complex (DISC)] . Positive_regulation DISC2 TNFSF10 15707589 1372895 To examine molecular mechanisms in cell resistance , we analyzed *induced* [DISC] in TRAIL-sensitive melanoma cells and showed that apoptosis initiating caspase-8 and caspase-10 were recruited to the DISC where they became activated through autocatalytical cleavage , leading to apoptosis through cleavage of downstream substrates such as caspase-3 and DFF45 . Positive_regulation DISC2 TNFSF10 18288942 1872783 For example , small interfering RNAs ( siRNAs ) that specifically knocked down expression of c-FLIP ( L ) in diverse human cancer cell lines , e.g. , lung and cervical cancer cells , augmented *induced* [DISC] recruitment , and thereby enhanced effector caspase stimulation and apoptosis . Positive_regulation DISC2 TNFSF10 19465019 2097335 Based on recent findings that the *dependent* [death inducing signaling complex (DISC)] forms and signals at the plasma membrane without being internalized , we investigated the possibility that agents that prevent endocytosis may stabilize the surface bound DISC and thereby enhance TRAIL dependent signaling . Positive_regulation DISC2 TNFSF10 19465019 2097339 Recruitment of FADD and caspase-8 to the *dependent* [DISC] was diminished in a concentration dependent manner in cells exposed to PAO . Positive_regulation DISC2 TNFSF10 19465019 2097341 PAO inhibited formation of the *dependent* [DISC] and therefore prevented all subsequent apoptotic events . Positive_regulation DISC2 TNFSF10 22456178 2691308 In TRAIL-resistant gastric cancer cells , did not *induce* effective [death inducing signalling complex (DISC)] formation in lipid rafts , accompanied with EGFR translocation into lipid rafts , and activation of EGFR pathway . Positive_regulation DISC2 TNFSF10 23051914 2703107 Furthermore , suppressing autophagy inhibited expression of antiapoptosis factors BIRC2/cIAP1 , BIRC3/cIAP2 , XIAP and CFLAR/c-FLIP and increased the formation of *induced* [death inducing signaling complex (DISC)] . Positive_regulation DISC2 TNFSF10 23070002 2685781 For example , small interfering RNAs ( siRNAs ) that specifically knockdown the expression of c-FLIP ( L ) in diverse human cancer cell lines augmented *induced* [DISC] recruitment and increased the efficacy of chemotherapeutic agents , thereby enhancing effector caspase stimulation and apoptosis . Positive_regulation DKC1 EPHB2 14708611 1181150 Inhibition of , Src , or Akt *suppressed* [telomerase] activity in HSC-1 cells , but to a lesser extent than did treatment with AG 1478 . Positive_regulation DKC1 ID1 10449746 637377 We demonstrate that ectopic expression of *leads* to activation of [telomerase] activity and immortalization of primary human keratinocytes . Positive_regulation DKC1 ID1 10908559 722492 Under these experimental conditions , expression did not *trigger* induction of [telomerase] activity , and there was progressive shortening of the telomeres that was accompanied by elevated p16 levels and prevalence of active Rb . Positive_regulation DKC1 IFI27 14612944 1163396 Overexpression of *suppressed* [telomerase] activity in tumor cells . Positive_regulation DKC1 RARB 14586406 1159576 Our previous work showed that acquisition of immortality at the dysplasia stage of oral cancer progression was consistently associated with four changes : loss of and p16INK4A expression , p53 mutations and *activation* of [telomerase] . Positive_regulation DKC1 TNF 15020249 1221502 *induces* rapid activation and nuclear translocation of [telomerase] in human lymphocytes . Positive_regulation DKC1 TNF 15020249 1221516 In this study , we show that tumor necrosis factor alpha (TNFalpha) induces telomerase activity in the cytoplasm of peripheral blood lymphocytes ( PBL ) at 60 min , followed by translocation of activated telomerase to the nucleus at 120 min. Conversely , the phosphoinositol 3-kinase (PI3K) inhibitor wortmannin blocks *induced* activation of [telomerase] , whereas the specific NF-kappaB translocation inhibitor SN-50 blocks TNFalpha induced nuclear translocation of activated telomerase . Positive_regulation DKC1 TNF 15326480 1296859 The present study described that , in the leukemic KG1 cells , *induced* no apoptosis but a senescence state characterized by prolonged growth arrest , increased beta-galactosidase activity , p21WAF-1 induction , decreased [telomerase] activity , telomeric disturbances ( shortening , losses , fusions ) , and additional chromosomal aberrations . Positive_regulation DKC1 TNF 19299722 2051939 Here , we show that modulation of levels in long-term cultures of human CD8 ( + ) T lymphocytes , by chronic exposure either to a neutralizing Ab or to an inhibitor of the TNF-alpha receptor-1 , increases proliferative potential , delays loss of CD28 expression , retards cytokine profile changes , and *enhances* [telomerase] activity . Positive_regulation DKC1 ZFP57 20235149 2244365 Constitutive expression of in C2C12 myoblasts *increased* mTERT expression and [telomerase] activity , and promoted the progression of the cell cycle and cell proliferation . Positive_regulation DKK1 CLU 23164821 2887156 To further elucidate how the *dependent* induction of [Dkk1] by Aß mediates neurotoxicity , we measured the effects of Aß and Dkk1 protein on whole-genome expression in primary neurons , finding a common pathway suggestive of activation of wnt-planar cell polarity (PCP)-c-Jun N-terminal kinase (JNK) signalling leading to the induction of genes including EGR1 ( early growth response-1 ) , NAB2 ( Ngfi-A binding protein-2 ) and KLF10 ( Krüppel-like factor-10 ) that , when individually silenced , protected against Aß neurotoxicity and/or tau phosphorylation . Positive_regulation DKK1 IL1B 19217321 2086497 The *induced* expressions of [DKK1] , Bax , Bad and caspase-3 dependent apoptosis of chondrocyte cultures . Positive_regulation DKK1 MSX1 19815336 2209333 We show that *induces* the expression of four different Wnt pathway inhibitor genes : [Dickkopf 1-3 (DKK1-3)] and secreted frizzled related protein 1 ( SFRP1 ) , and provide evidence that high expression of two of these genes correlates with good prognosis . Positive_regulation DKK1 TNF 20858621 2346849 In vitro , rapidly *increased* [Dkk-1] expression in primary osteoblasts and effectively blocked osteoblast differentiation . Positive_regulation DLC1 TNS1 19440389 2078577 In addition to properly localizing focal adhesions and preserving RhoGAP activity , DLC1 interaction with through this novel focal adhesion binding site *contributes* to the growth-suppressive activity of [DLC1] . Positive_regulation DLC1 TNS1 22307599 2552226 Importantly , *activation* of [DLC1] by or its actin binding domain drastically reduced the anchorage independent growth of transformed cells . Positive_regulation DLD COL17A1 12786825 1096731 This reflects the pivotal *role* of in [LAD] . Positive_regulation DLG1 CAPN8 15784649 1417219 Prolonged positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ( AMPA ) receptors induces *mediated* [PSD-95/Dlg/ZO-1] protein degradation and AMPA receptor down-regulation in cultured hippocampal slices . Positive_regulation DLG2 CAPN8 15784649 1417233 Prolonged positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ( AMPA ) receptors induces *mediated* [PSD-95/Dlg/ZO-1] protein degradation and AMPA receptor down-regulation in cultured hippocampal slices . Positive_regulation DLG3 CAPN8 15784649 1417247 Prolonged positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ( AMPA ) receptors induces *mediated* [PSD-95/Dlg/ZO-1] protein degradation and AMPA receptor down-regulation in cultured hippocampal slices . Positive_regulation DLG4 CAPN8 15784649 1417261 Prolonged positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ( AMPA ) receptors induces *mediated* [PSD-95/Dlg/ZO-1] protein degradation and AMPA receptor down-regulation in cultured hippocampal slices . Positive_regulation DLG4 EFNB1 11483650 844452 Heterologous coexpression of a chimeric protein with SAP90/PSD-95 in COS cells *leads* to translocation of [SAP90/PSD-95] from the cytosol to the membrane . Positive_regulation DLG4 EPHB2 18776894 1969175 *dependent* [PSD-95] induction in the gustatory cortex is necessary for taste learning , but not retrieval . Positive_regulation DLG4 GRIK2 20219637 2249320 The released GABA activates postsynaptic GABA ( A ) receptors , which suppress the ischemic depolarization and decrease the association of signaling module [Gluk2-PSD-95-MLK3] *induced* by the activation of postsynaptic receptors . Positive_regulation DLG5 CAPN8 15784649 1417275 Prolonged positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ( AMPA ) receptors induces *mediated* [PSD-95/Dlg/ZO-1] protein degradation and AMPA receptor down-regulation in cultured hippocampal slices . Positive_regulation DLL4 ANGPT1 21212269 2397008 Correspondingly , the GSK3ß inhibitor up-regulated Dll4 , whereas depletion of ß-catenin by siRNA blocked *induced* [Dll4] expression , indicating the indispensability of ß-catenin in Ang1 mediated up-regulation of Dll4 . Positive_regulation DLL4 JAG1 19524514 2092996 Upon glycosylation of Notch , [Dll4-Notch] signaling is *enhanced* , whereas has weak signaling capacity and competes with Dll4 . Positive_regulation DLL4 TNF 1847684 153504 5. Inhibition of PL-A2 activity by appropriate drugs markedly diminished *induced* [delta 4Ach] release and resulted also in a strong decrease in TNF induced cytotoxicity . Positive_regulation DLL4 TNF 1847684 153506 6. Other drugs , including serine protease inhibitors , which strongly inhibit TNF induced cytotoxicity , also decreased the *induced* [delta 4Ach] release , whereas LiCl potentiated both TNF mediated effects . Positive_regulation DLX3 TP63 17164413 1679046 Homeobox gene [Dlx3] is *regulated* by during ectoderm development : relevance in the pathogenesis of ectodermal dysplasias . Positive_regulation DLX4 TNF 7806369 292513 We conclude that [TNF-BP1] is released in bacteremia and that release in vivo is partially *dependent* on the presence of . Positive_regulation DLX5 MSX1 20824629 2346074 Furthermore , [Dlx5] *requires* for its expression in the context of frontal bone development . Positive_regulation DMBT1 EPHB2 15760920 1409733 *Induction* of [DMBT1] expression by reduced activity during a gastric mucosa differentiation-like process and its association with human gastric cancer . Positive_regulation DMD CAPN8 15963350 1423152 Based on pathological , molecular , and physiological findings in 3 animal models and human cases , we propose a novel scheme that a vicious cycle formed by increased sarcolemma ( SL ) permeability , preferential *activation* of over calpastatin , and translocation and cleavage of [dystrophin (Dys)] commonly lead to advanced HF . Positive_regulation DMD EPHB2 17562849 1778626 The results suggest that activation of PKC inhibits alpha ( 1 ) -adrenoceptor mediated contractions in PUA through down-regulation of the thick-filament pathway and decreased myosin light chain phosphorylation , but that it enhances the contractions in NPUA through its effect on the [thin-filament] regulatory pathway and *activation* of and actin polymerization . Positive_regulation DMD TMOD1 12975349 1139824 These studies indicate that the interaction of with tropomyosin is *critical* for [thin filament] stability . Positive_regulation DMP1 EPHB2 21678127 2538741 Collectively , our observations indicate that FGF signaling coordinately regulates mineralization related genes in the osteoblast lineage and that signaling is *essential* for [Dmp1] expression and osteocyte differentiation . Positive_regulation DNAJB9 EPHB2 20008963 2217594 Further study revealed that both [MDG-1] and S1P *induce* Akt and phosphorylation in a dose- and time dependent manner , an effect that is attenuated by pre-treatment with either the Akt inhibitor wortmannin or the ERK inhibitor PD98059 , and MDG-1 can also induce eNOS phosphorylation and increases in production of NO . Positive_regulation DNAJC5 TNF 23806004 2815609 Specifically , the high-molecular weight sub-fraction [CSP-AU1] ( average of 38.5 kDa ) *induced* NO and cytokine [interleukin ( IL ) -1a , -1ß , -6 , -10 , ( TNF ; designated previously as TNF-a ) , and granulocyte macrophage-colony stimulating factor ( GM-CSF ) ] production by human peripheral blood mononuclear cells ( PBMCs ) and monocyte/macrophages . Positive_regulation DNASE1 FAS 11093032 754930 However , osmotic cell shrinkage almost abolished *induced* DNA fragmentation ( as revealed by propidium iodide staining ) and the activation of a [DNase] as evidenced from SDS-PAGE gel assay . Positive_regulation DNASE2 FAS 11093032 754931 However , osmotic cell shrinkage almost abolished induced DNA fragmentation ( as revealed by propidium iodide staining ) and the *activation* of a [DNase] as evidenced from SDS-PAGE gel assay . Positive_regulation DNLZ PLAU 7523424 272194 Both the *inducing* activity and the angiogenic activity of [SK-Hep1] cell conditioned medium copurify with a relatively acid-resistant peptide that has moderate affinity for heparin and M ( r ) < 18 kDa > 3.5 kDa . Positive_regulation DNLZ PLAU 8908197 394501 We now report that [SK-Hep 1] or S180 cell conditioned medium rapidly *induces* a 4- to 5-fold increase in cell bound activity and in the high-affinity binding of 125I-prouPA to vascular endothelial cells . Positive_regulation DNM1 CAPN8 16864575 1613458 We report here that this [dynamin 1] degradation was the *result* of activation induced by the sustained calcium influx mediated by N-methyl-D-aspartate receptors in hippocampal neurons . Positive_regulation DNM1 CAPN8 22160219 2574990 Our results showed that Dutch mutant Aß ( E22Q ) induced *mediated* cleavage of [dynamin 1] and a significant decrease in synaptic contacts in mature hippocampal cultures . Positive_regulation DNM1 SRGN 14739229 1235021 The granzyme complex from cytotoxic granules *requires* [dynamin] for endocytosis . Positive_regulation DNM2 SRGN 14739229 1235023 The granzyme complex from cytotoxic granules *requires* [dynamin] for endocytosis . Positive_regulation DNM3 SRGN 14739229 1235019 The granzyme complex from cytotoxic granules *requires* [dynamin] for endocytosis . Positive_regulation DNMT1 EPHB2 23423710 2771182 PDGF induced [DNA methyltransferase 1 (DNMT1)] expression was *mediated* by activation of PI3K/Akt and signaling in RASM cells . Positive_regulation DNMT1 TNF 19730253 2186480 Additionally , ( 50 ng/mL ) *increased* the expression of [DNA methyltransferase 1] . Positive_regulation DOCK3 NEDD9 22677287 2611462 Elongated mesenchymal migration of cancer cells is driven by Rac1 activation *mediated* by the adaptor and the exchange factor [DOCK3] . Positive_regulation DOK1 ANGPT1 12665569 1074871 Introduction of a Tie2 mutant lacking tyrosine residue 1106 into endothelial cells interferes with [Dok-R] phosphorylation in *response* to . Positive_regulation DOK1 IL1B 15187102 1256318 Notably , *suppresses* the ability of the IGF-I receptor tyrosine kinase to phosphorylate its major [docking protein] , insulin receptor substrate-1 , in MCF-7 breast carcinoma cells . Positive_regulation DOK2 ANGPT1 12665569 1074872 Introduction of a Tie2 mutant lacking tyrosine residue 1106 into endothelial cells interferes with [Dok-R] phosphorylation in *response* to . Positive_regulation DOK2 IL1B 15187102 1256319 Notably , *suppresses* the ability of the IGF-I receptor tyrosine kinase to phosphorylate its major [docking protein] , insulin receptor substrate-1 , in MCF-7 breast carcinoma cells . Positive_regulation DOK3 ANGPT1 12665569 1074868 Introduction of a Tie2 mutant lacking tyrosine residue 1106 into endothelial cells interferes with [Dok-R] phosphorylation in *response* to . Positive_regulation DOK3 IL1B 15187102 1256315 Notably , *suppresses* the ability of the IGF-I receptor tyrosine kinase to phosphorylate its major [docking protein] , insulin receptor substrate-1 , in MCF-7 breast carcinoma cells . Positive_regulation DOK4 ANGPT1 12665569 1074867 Introduction of a Tie2 mutant lacking tyrosine residue 1106 into endothelial cells interferes with [Dok-R] phosphorylation in *response* to . Positive_regulation DOK4 IL1B 15187102 1256314 Notably , *suppresses* the ability of the IGF-I receptor tyrosine kinase to phosphorylate its major [docking protein] , insulin receptor substrate-1 , in MCF-7 breast carcinoma cells . Positive_regulation DOK5 ANGPT1 12665569 1074866 Introduction of a Tie2 mutant lacking tyrosine residue 1106 into endothelial cells interferes with [Dok-R] phosphorylation in *response* to . Positive_regulation DOK5 IL1B 15187102 1256313 Notably , *suppresses* the ability of the IGF-I receptor tyrosine kinase to phosphorylate its major [docking protein] , insulin receptor substrate-1 , in MCF-7 breast carcinoma cells . Positive_regulation DOK6 ANGPT1 12665569 1074870 Introduction of a Tie2 mutant lacking tyrosine residue 1106 into endothelial cells interferes with [Dok-R] phosphorylation in *response* to . Positive_regulation DOK6 IL1B 15187102 1256317 Notably , *suppresses* the ability of the IGF-I receptor tyrosine kinase to phosphorylate its major [docking protein] , insulin receptor substrate-1 , in MCF-7 breast carcinoma cells . Positive_regulation DOK7 ANGPT1 12665569 1074869 Introduction of a Tie2 mutant lacking tyrosine residue 1106 into endothelial cells interferes with [Dok-R] phosphorylation in *response* to . Positive_regulation DOK7 IL1B 15187102 1256316 Notably , *suppresses* the ability of the IGF-I receptor tyrosine kinase to phosphorylate its major [docking protein] , insulin receptor substrate-1 , in MCF-7 breast carcinoma cells . Positive_regulation DOK7 NES 18165682 1869625 Here , we identify a chromosome region maintenance 1-dependent nuclear export signal (NES) in the COOH-terminal moiety and demonstrate that the *mediated* cytoplasmic location of [Dok-7] is essential for regulating the interaction with MuSK in myotubes . Positive_regulation DONSON FOXA1 20628005 2316504 Furthermore , down-regulation of in LNCaP cells substantially *reduces* [UGT2B17] mRNA levels . Positive_regulation DONSON FOXA1 20736324 2345814 We recently reported that *regulates* the basal expression of the [UGT2B17] gene in prostate cancer cells . Positive_regulation DPF2 IL1B 16847181 1588149 The messenger RNA expressions of [LARC] ( liver and activation regulated chemokine ) , GMCSF ( granulocyte-macrophage colony stimulating factor ) , epiregulin , ICAM1 ( intercellular adhesion molecule 1 ) , and TGFA ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation DPP4 GLP1R 22025647 2539982 The observed renoprotection is probably attributable to inhibition of [DPP IV] activity , mimicking of incretin action , and *activation* of the . Positive_regulation DPP4 TNF 10880264 709119 The fact that translation and probably translocation of [CD26] toward the cell surface can be *regulated* by IL-12 and reveals new aspects about the control of this T(H1)marker . Positive_regulation DPP4 TNF 15614194 1387629 We analyzed reactive oxygen intermediate ( ROI ) production by peripheral blood granulocytes , the production of IL-2 , IL-5 , IL-10 , IL-12 , and cytokines by lymphocytes , and the *activation* of CD25 , [CD26] , CD69 , CD71 , and HLA DR antigen expression . Positive_regulation DPP4 TNF 24920931 2941905 The stimulation of adipocytes with *increased* the release of [DPP4] irrespective of glucose concentration . Positive_regulation DPP4 TNF 7962267 279351 These findings indicate that and IL-1 alpha *stimulate* [DPPIV] expression and activity in human luteinizing granulosa cells in vitro and suggest the involvement of cytokines in the differentiation of granulosa cells during corpus luteum formation . Positive_regulation DPYD TNF 23301483 2712529 Compared with EATD group , the level of [DPD/Cr] and Ca/Cr in the other three EA groups had no statistical differences ( all P > 0.05 ) , but the level of ALP , BGP , and ICTP in serum *increased* significantly ( all P < 0.01 ) , the level of E2 and PICP in serum decreased significantly ( all P < 0.01 ) . Positive_regulation DPYSL2 CAPN8 17402852 1721289 Inhibition of activation *prevented* NMDA induced [CRMP-2] proteolysis and redistribution of CRMP-2 from the neurites to the cell body , while attenuating neurite damage and neuronal cell injury . Positive_regulation DPYSL2 CAPN8 19735446 2152719 Activated CaMKII directly phosphorylates collapsin response mediator protein ( CRMP) 2 which is independent of *mediated* cleavage of [CRMP2] . Positive_regulation DPYSL3 CAPN8 16987501 1640561 Recently , we have shown that in primary cortical neurons (PCN) NMDA and oxidative stress ( H ( 2 ) O ( 2 ) ) caused a *dependent* cleavage of [DPYSL3] ( 62 kDa ) resulting in the appearance of a lower molecular weight form ( 60 kDa ) of DPYSL3 . Positive_regulation DPYSL3 CAPN8 18053648 1852515 Recently we have shown that glutamate excitotoxicity and oxidative stress result in *dependent* cleavage of [DPYSL3] , and that NOS plays a role in this process [ R. Kowara , Q. Chen , M. Milliken , B. Chakravarthy , Calpain mediated truncation of dihydropyrimidinase-like 3 protein ( DPYSL3 ) in response to NMDA and H2O2 toxicity , J. Neurochem. 95 ( 2005 ) 466-474 ; Positive_regulation DRG1 TNF 11849773 912921 To further understand the *role* of in [DRG] , we injected rat L5 DRG with biotinylated TNF alpha , neurobiotin , or vehicle , and detected translocation of the biotin tag by avidin-biotin histochemistry . Positive_regulation DRG1 TNF 12684435 1078022 In [DRG] , p38 activation is *blocked* by systemic inhibition . Positive_regulation DRG1 TNF 21659885 2475822 The expression of and interleukin-1ß significantly *increased* at 4 and 8 weeks in the [DRG] of rats with pain . Positive_regulation DRG2 TNF 11849773 912922 To further understand the *role* of in [DRG] , we injected rat L5 DRG with biotinylated TNF alpha , neurobiotin , or vehicle , and detected translocation of the biotin tag by avidin-biotin histochemistry . Positive_regulation DRG2 TNF 12684435 1078023 In [DRG] , p38 activation is *blocked* by systemic inhibition . Positive_regulation DRG2 TNF 21659885 2475850 The expression of and interleukin-1ß significantly *increased* at 4 and 8 weeks in the [DRG] of rats with pain . Positive_regulation DROSHA CAPN8 16092937 1443479 Purified PSDs did not exhibit [RNAse III] activity , but *caused* release of dicer from PSDs in an enzymatically active form , together with eIF2c . Positive_regulation DSG3 PKP1 24056861 2920880 *prevents* loss of [Dsg3] and other desmosomal proteins from cell-cell borders and prevents alterations in desmosome ultrastructure in keratinocytes treated with PV IgG . Positive_regulation DST EPHB2 18854640 2041172 [BPA] rapidly *induced* activation of extracellular signal regulated kinase ( ) 1/2 and p38 MAPK at 15 min , but the effect of BPA ( 10 microM ) on stimulation of cell growth was not blocked by pretreatment with inhibitors of MEK ( PD98059 ) or p38 ( SB203580 ) in a dose dependent manner . Positive_regulation DST TNF 11859116 914752 In contrast , IL-1alpha , IL-1beta , , IFN-gamma-inducible protein-10 , and Th2 cytokines such as IL-4 and IL-10 did not *induce* [IL-18BPa] . Positive_regulation DST TNF 19769995 2158976 Moreover , we observed that induction of AK activation and gene expression *require* lower levels of [BPA] than apoptosis or TNF-alpha protein excretion . Positive_regulation DST TNF 20131228 2219905 *induced* RA synovial fibroblast [IL-18BPa] and IL-18 in a time dependent manner ( P < 0.05 ) . Positive_regulation DUOX1 FAS 15917250 1433511 These inhibitors and p47phox protein knockdown inhibited the early CD95L induced ROS response , suggesting that ceramide and PKCzeta are upstream events of the induced [Nox/Duox] *activation* . Positive_regulation DUOX1 TNF 24406179 2884140 can *induce* [DUOX-1] expression increasing in lipid raft , then the DUOX-1 can be activated to increase reactive oxygen species level ; Positive_regulation DUOX2 FAS 15917250 1433509 These inhibitors and p47phox protein knockdown inhibited the early CD95L induced ROS response , suggesting that ceramide and PKCzeta are upstream events of the induced [Nox/Duox] *activation* . Positive_regulation DUSP1 ANGPT1 24308939 2877818 differentially *induces* [DUSP1] , DUSP4 , and DUSP5 in human umbilical vein endothelial cells through activation of the PI-3 kinase , ERK1/2 , p38 , and SAPK/JNK pathways . Positive_regulation DUSP1 EPHB2 11104676 756448 Compartment-specific regulation of extracellular signal regulated kinase ( ERK ) and c-Jun N-terminal kinase (JNK) mitogen activated protein kinases ( MAPKs ) by dependent and non-ERK dependent *inductions* of MAPK phosphatase (MKP)-3 and [MKP-1] in differentiating P19 cells . Positive_regulation DUSP1 EPHB2 15339908 1323514 We found that both Src-kinase and p42/p44 activity are *critical* for thrombin induced [CL-100] expression , whereas phosphatidylinositol 3-kinase and protein kinase C activity were not required . Positive_regulation DUSP1 EPHB2 16286470 1509636 activation by serum *increased* the endogenous level of ubiquitinated phospho-Ser ( 296 ) [MKP-1] and the degradation of MKP-1 . Positive_regulation DUSP1 EPHB2 23076500 2740556 The extracellular signal regulated kinase ( ) inhibitor , U0126 , *blocked* Gln induced [MKP-1] phosphorylation and protein induction , as well as Gln suppression of CD . Positive_regulation DUSP1 EPHB2 24126911 2875048 Inhibition of either the or the AKT pathway *attenuated* rapamycin mediated [MKP-1] induction . Positive_regulation DUSP1 EPHB2 24253595 2910467 We examined the *role* of in the regulation of [MKP1] and JNK , and p38 activities and apoptosis . Positive_regulation DUSP1 EPHB2 9148952 430026 Inhibition of LPA stimulated MEK and activation with PD98059 and pertussis toxin , a selective inhibitor of Gi-protein coupled signaling pathways , *reduced* LPA stimulated [MKP-1] expression by only 50 % , suggesting the presence of additional MEK- and ERK independent pathways for MKP-1 expression . Positive_regulation DUSP1 F2R 20671228 2317153 an ERK independent signal was *necessary* for the approximately 12-fold [MKP-1] induction by thrombin plus EGF . Positive_regulation DUSP1 FBXO32 19117950 2036978 interacted with and *triggered* [MKP-1] for ubiquitin mediated degradation . Positive_regulation DUSP1 IL1B 15476200 1319368 rapidly *up-regulated* [MKP-1] , coinciding with reciprocal down-regulation of ERK , JNK , and p38 MAPK phosphorylation . Positive_regulation DUSP1 IL1B 15476200 1319369 In addition , dexamethasone augmented *induced* up-regulation of [MKP-1] , and this was associated with inhibition of ERK , JNK , and p38 MAPK phosphorylation and IL-6 expression . Positive_regulation DUSP1 IL1B 24692548 2935237 rapidly *induced* [DUSP1] expression and RNA silencing revealed a transient role in feedback inhibition of MAPKs and inflammatory gene expression . Positive_regulation DUSP1 MAP2K6 19289102 2063922 The effect of TRH on [MKP-1] expression was completely prevented in the *presence* of the inhibitor , U0126 . Positive_regulation DUSP1 MAP2K6 24126911 2875054 Inhibition of either the or the AKT pathway *attenuated* rapamycin mediated [MKP-1] induction . Positive_regulation DUSP1 MAP2K6 24253595 2910473 We examined the *role* of in the regulation of [MKP1] and JNK , and p38 activities and apoptosis . Positive_regulation DUSP1 MAP2K6 8557667 347532 In contrast , selective stimulation of the ERK pathway by 12-O-tetradecanoylphorbol-13-acetate or following expression of constitutively active , the upstream dual specificity kinase of ERK did not *induce* the transcription of [MKP-1] . Positive_regulation DUSP1 MAP2K6 9148952 430033 Inhibition of LPA stimulated and ERK activation with PD98059 and pertussis toxin , a selective inhibitor of Gi-protein coupled signaling pathways , *reduced* LPA stimulated [MKP-1] expression by only 50 % , suggesting the presence of additional MEK- and ERK independent pathways for MKP-1 expression . Positive_regulation DUSP1 RARB 12186877 997727 Among the three RAR subtypes , RARalpha and RARgamma , but not , *mediated* the t-RA induced [MKP-1] expression . Positive_regulation DUSP1 TNF 11137629 769997 In contrast , *induces* [MKP-1] expression in PC12 cells and does not alter MKP-1 expression in HeLa cells . Positive_regulation DUSP1 TNF 11137629 769999 Both bpV ( phen ) and *induce* [MKP-1] expression in OVCAR-3 cell line but with different dynamics : TNF-alpha causes transient and bpV ( phen ) sustained induction of MKP-1 expression . Positive_regulation DUSP1 TNF 16109884 1474090 HIV nef protein was sufficient to reduce release and *induce* [MKP-1] in healthy macrophages . Positive_regulation DUSP1 TNF 18441094 1932697 In HASM cells , dexamethasone and *induced* [MKP-1] expression ( both mRNA and protein ) rapidly . Positive_regulation DUSP1 TNF 9553092 499480 In rat mesangial cells , pretreatment of the cells with Ro318220 blocked expression of [MKP-1] *induced* by . Positive_regulation DUSP1 TNF 9553092 499481 Specifically , *induction* of [MKP-1] by appears to be responsible for protection of the cells from apoptosis by preventing a prolonged activation of JNK . Positive_regulation DUSP1 TNF 9950771 595732 Although originally characterized as a PKC inhibitor , Ro-318220 inhibited *induced* [MKP-1] expression through a mechanism other than blocking the PKC pathway . Positive_regulation DUSP1 TNF 9950771 595733 Furthermore , inhibition of the PKC pathway neither significantly affected *induced* [MKP-1] expression nor made cells susceptible to toxic effect of TNF-alpha . Positive_regulation DUSP4 ANGPT1 24308939 2877819 differentially *induces* DUSP1 , [DUSP4] , and DUSP5 in human umbilical vein endothelial cells through activation of the PI-3 kinase , ERK1/2 , p38 , and SAPK/JNK pathways . Positive_regulation DUSP4 EPHB2 21317287 2410638 We show that serum and PDGF induced *dependent* [MKP-2] expression in wild type MEFs but not in MKP-2 ( -/- ) MEFs . Positive_regulation DUSP4 MAP2K6 11162624 782296 Pancreatic tumor cells with mutant K-ras suppress ERK activity by dependent *induction* of [MAP kinase phosphatase-2] . Positive_regulation DUSP5 ANGPT1 24308939 2877820 differentially *induces* DUSP1 , DUSP4 , and [DUSP5] in human umbilical vein endothelial cells through activation of the PI-3 kinase , ERK1/2 , p38 , and SAPK/JNK pathways . Positive_regulation DUSP6 EPHB2 10702230 672500 The pH activity profiles of *activated* [MKP3] clearly indicated the involvement of general acid catalysis , a hallmark of protein-tyrosine phosphatase catalysis . Positive_regulation DUSP6 EPHB2 10702230 672501 In addition , *activated* [MKP3] catalyzes intermediate hydrolysis 5-6-fold more efficiently and binds ligands up to 19-fold more tightly . Positive_regulation DUSP6 EPHB2 10811804 714655 Consistent with this , we show that peptides representing docking sites within the target substrates Elk-1 and p90 ( rsk ) inhibit *dependent* activation of [MKP-3] . Positive_regulation DUSP6 EPHB2 11104676 756449 Compartment-specific regulation of extracellular signal regulated kinase ( ERK ) and c-Jun N-terminal kinase (JNK) mitogen activated protein kinases ( MAPKs ) by ERK dependent and *dependent* inductions of [MAPK phosphatase (MKP)-3] and MKP-1 in differentiating P19 cells . Positive_regulation DUSP6 EPHB2 16831426 1587461 We conclude that [MKP-3/Pyst1] expression is *mediated* by activation and that negative feedback control predominates in limiting the extent of FGF induced ERK activity . Positive_regulation DUSP6 EPHB2 17459723 1743205 Furthermore , we demonstrate the use of a 96-well plate format refolding assay in which the *induced* activity of [MKP3] is simulated by 33 % DMSO . Positive_regulation DUSP6 EPHB2 18321244 1904416 These findings identify a conserved Ets-factor dependent mechanism by which signalling *activates* [DUSP6/MKP-3] transcription to deliver ERK1/2-specific negative-feedback control of FGF signalling . Positive_regulation DUSP6 EPHB2 19106095 2031536 Moreover , activated *induces* [mkp3] expression , leading to restoration of MKP3 levels after 1-2 h and a concomitant dephosphorylation of Erk in cells with activated PDGFRalpha . Positive_regulation DUSP6 EPHB2 20097731 2226253 Our results indicate that [DUSP6] expression is *regulated* by signaling and that DUSP6 exerts antitumor effects via negative feedback regulation , pointing to an important feedback loop in NSCLC . Positive_regulation DUSP6 MAP2K6 22521266 2630829 Mutation of two ERK phosphorylation sites on MKP-3 rendered it resistant to insulin and constitutively active *induced* [MKP-3] protein degradation . Positive_regulation DUT CAPN8 21625588 2436883 The presence or absence of the dUTP-analogue a , ß-imido-dUTP did not show any effect on Ca ( 2+ ) <-calpain> *induced* cleavage of human [dUTPase] . Positive_regulation DUT CAPN8 21625588 2436897 Gel electrophoretic analysis showed that Ca ( 2+ ) <-calpain> *induced* cleavage of human [dUTPase] resulted in several distinctly observable dUTPase fragments . Positive_regulation DUT CAPN8 21625588 2436911 Results argue for a mechanism where Ca ( 2+ ) <-calpain> may *regulate* nuclear availability and degradation of [dUTPase] . Positive_regulation DUT NES 20461535 2283149 We have discovered for the first time that the *dependent* translocation of [dUTPase] is different for SGIV than for members of other species , which depend on a nuclear localization signal . Positive_regulation DVL1 F2R 21331223 2360772 Formation of the *induced* [DvL-G] ( a13 ) axis is carried out independently of Wnt , Fz and the co-receptor LRP5/6 ( low density lipoprotein related protein 5/6 ) since neither siRNA-LRP5/6 co-receptors nor the presence of SFRPs ; Positive_regulation DVL1 FZD4 20212039 2249118 activation of canonical beta-catenin signaling *requires* the adapter protein [Dishevelled (Dvl)] . Positive_regulation DVL2 F2R 21331223 2360773 Formation of the *induced* [DvL-G] ( a13 ) axis is carried out independently of Wnt , Fz and the co-receptor LRP5/6 ( low density lipoprotein related protein 5/6 ) since neither siRNA-LRP5/6 co-receptors nor the presence of SFRPs ; Positive_regulation DVL2 FZD4 20212039 2249129 activation of canonical beta-catenin signaling *requires* the adapter protein [Dishevelled (Dvl)] . Positive_regulation DVL2 WNT7A 24711502 2931816 Here we describe a third level of activity where *increases* the polarity and directional migration of mouse satellite cells and human myogenic progenitors through activation of [Dvl2] and the small GTPase Rac1 . Positive_regulation DVL3 F2R 21331223 2360774 Formation of the *induced* [DvL-G] ( a13 ) axis is carried out independently of Wnt , Fz and the co-receptor LRP5/6 ( low density lipoprotein related protein 5/6 ) since neither siRNA-LRP5/6 co-receptors nor the presence of SFRPs ; Positive_regulation DVL3 FZD4 20212039 2249140 activation of canonical beta-catenin signaling *requires* the adapter protein [Dishevelled (Dvl)] . Positive_regulation DYNLRB1 TNF 12709026 1083026 The expression of TLR2 protein by hepatocytes was also remarkably *up-regulated* by IL-1alpha and , to a lesser extent , by as well , but not by LPS or [BLP] . Positive_regulation DYNLRB1 TNF 18675993 2011266 The role of P38 MAPK and PKC in [BLP] *induced* release , apoptosis , and NFkappaB activation in THP-1 monocyte cells . Positive_regulation DYNLRB1 TNF 21549062 2429211 In control group [BLP] stimulation ( 10 , 100 , 1 000 ng/ml ) could *induce* THP-1 activation and production ( pg/ml : 184.86±32.51 , 3 215.88±167.09 , 6 042.96±245.37 ) in a dose dependent manner . Positive_regulation DYRK1A CAPN8 19059382 2017882 Moreover , the use of primary hepatocytes/Kupffer cells co-culture showed that degradation of [DYRK1A] induced by hyperhomocysteinemia *requires* activation . Positive_regulation DYSF TNF 16957579 1611133 In vitro , [dysferlin] can be *induced* in endothelial cells by stimulation with . Positive_regulation E2F1 AXIN2 15766563 1383688 is *induced* by [E2F1] and therefore acts as a point of cross-talk between the pRb/E2F and Wnt/beta-catenin pathways : two of the most frequently deregulated pathways in human cancers . Positive_regulation E2F1 CAPN8 16088944 1466310 [E2F1] *induces* cell death , activation , and MDMX degradation in a transcription independent manner implicating a novel role for E2F1 in neuronal loss in SIV encephalitis . Positive_regulation E2F1 CCND1 11260083 796101 indirectly *activates* the [transcription factor E2F-1] . Positive_regulation E2F1 CCND1 12237874 989240 Because normally *activates* [E2F-1] , up-regulation of cyclin D1 may lead to E2F-1 overexpression in benign and malignant thyroid lesions . Positive_regulation E2F1 CCND1 16407216 1527185 The role of IKKalpha in regulating [E2F1] was not the *result* of reduced levels of , as overexpression of this gene could not overcome the effects of IKKalpha knock-down . Positive_regulation E2F1 CCND1 19564413 2117432 Cyclin E2 induction by estrogen was accompanied by recruitment of E2F1 to the cyclin E1 and E2 promoters , and induction was *sufficient* for [E2F1] recruitment . Positive_regulation E2F1 CCND1 7970707 280095 *Activation* of the [E2F] transcription factor by is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation E2F1 CCND1 7970707 280128 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Positive_regulation E2F1 CCND1 9001421 410315 These studies show that Rb interaction with [E2F1] is *regulated* by cdk4 and within p210 BCR-ABL transformed leukemia cells in early G1 phase of the cell cycle . Positive_regulation E2F1 CTGF 23902294 2830438 TGFß and attenuate CREB and *augment* [E2F1] transcriptional activation with the likely effect of altering actin cytoskeletal and cell growth/hypertrophic gene activity with implications for cell dysfunction in diabetic kidney disease . Positive_regulation E2F1 EPHB2 11371570 834847 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and and *activation* of cAMP-responsive element binding protein ( CREB ) , NF-kappaB , and [E2F] ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation E2F1 EPHB2 21871886 2491366 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the cyclin dependent kinase inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and [E2F1] expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Positive_regulation E2F1 FOXO1 17482685 1738753 We found that expression of endogenous and FOXO3a is *induced* by [E2F-1] . Positive_regulation E2F1 FOXO1 23966291 2845541 RNAi mediated silencing of *impaired* [E2F1] binding to the promoters of cooperative target genes . Positive_regulation E2F1 IFI27 21312237 2398690 WIN 55,212-2 also upregulated phospho-ERK1/2 , *induced* and Cip1/WAF1/p21 expression , decreased cyclin D1 and cyclin E expression , decreased Cdk 2 , Cdk 4 , and Cdk 6 expression levels , and decreased phospho-Rb and [E2F-1] expression . Positive_regulation E2F1 IFI27 9096690 422569 Although HL-AS5 and HL-60/V2 cells did not exhibit obvious differences in the phosphorylation status of the retinoblastoma protein ( pRB ) , in [E2F] complex formation , or in *induction* following PMA exposure , inhibition of activity of cyclin dependent kinase-2 was attenuated in the antisense expressing line . Positive_regulation E2F1 MAP2K6 11551910 874999 This Ras induced increase in [E2F-1] levels is *dependent* on both and PKB , and it is retinoblastoma independent . Positive_regulation E2F1 MAP2K6 21871886 2491372 Ectopic expression of a constitutively active AR inhibited *mediated* regulation of the differentiation markers , neuron-specific enolase and neutral endopeptidase , and the cyclin dependent kinase inhibitors , p16(INK4A) and p21 ( CIP1 ) , but not Rb phosphorylation and [E2F1] expression , indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling . Positive_regulation E2F1 TNF 20308528 2244663 Treatment of VSMC with AR inhibitor sorbinil prevented HG- as well as *induced* phosphorylation of retinoblastoma protein and activation of [E2F-1] . Positive_regulation E2F1 TNF 21738216 2532207 In contrast , stimulation of VSMCs *enhanced* the association of [E2F1] with proliferative promoters like thymidylate synthase and cdc25A , while Rb was dissociated . Positive_regulation E2F1 TNFSF10 17610067 1774762 In the sensitive cell line an *upregulation* of multiple [E2F1-] and p53-inducible proapaptotic and cell-cycle regulating target genes by Topotecan as well as was observed . Positive_regulation E2F2 CCND1 7970707 280097 *Activation* of the [E2F] transcription factor by is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation E2F2 CCND1 7970707 280129 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Positive_regulation E2F2 EPHB2 11371570 834848 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and and *activation* of cAMP-responsive element binding protein ( CREB ) , NF-kappaB , and [E2F] ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation E2F2 IFI27 9096690 422571 Although HL-AS5 and HL-60/V2 cells did not exhibit obvious differences in the phosphorylation status of the retinoblastoma protein ( pRB ) , in [E2F] complex formation , or in *induction* following PMA exposure , inhibition of activity of cyclin dependent kinase-2 was attenuated in the antisense expressing line . Positive_regulation E2F3 CCND1 7970707 280099 *Activation* of the [E2F] transcription factor by is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation E2F3 CCND1 7970707 280130 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Positive_regulation E2F3 EPHB2 11371570 834849 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and and *activation* of cAMP-responsive element binding protein ( CREB ) , NF-kappaB , and [E2F] ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation E2F3 IFI27 9096690 422573 Although HL-AS5 and HL-60/V2 cells did not exhibit obvious differences in the phosphorylation status of the retinoblastoma protein ( pRB ) , in [E2F] complex formation , or in *induction* following PMA exposure , inhibition of activity of cyclin dependent kinase-2 was attenuated in the antisense expressing line . Positive_regulation E2F4 CCND1 18478976 1910557 however , in HELFs treated with 100 micromol/L B [ a ] P , both and CDK4 negatively *regulate* the [E2F-4] expression . Positive_regulation E2F4 CCND1 22357515 2520893 When suppressing AP-1 activity , the and CDK4 expression levels decreased and the [E2F-4] expression level *increased* in curcumin plus silica group , as compared with silica group . Positive_regulation E2F4 CCND1 7970707 280101 *Activation* of the [E2F] transcription factor by is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation E2F4 CCND1 7970707 280131 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Positive_regulation E2F4 EPHB2 11371570 834850 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and and *activation* of cAMP-responsive element binding protein ( CREB ) , NF-kappaB , and [E2F] ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation E2F4 EPHB2 22214150 2519150 It was found that and JNK were *involved* in silica induced cyclin D1 and CDK4 overexpression and the decreased expression of [E2F-4] . Positive_regulation E2F4 EPHB2 23919615 2826233 Treatment of quiescent HIEC with serum *induced* ERK1/2 activation , E2F4 phosphorylation , [E2F4] nuclear translocation and G1/S phase transition while inhibition of signaling by U0126 prevented these events . Positive_regulation E2F4 EPHB2 23919615 2826253 The present results indicate that activation and GSK3 inhibition are both *required* for [E2F4] phosphorylation as well as its nuclear translocation and S phase entry in HIEC . Positive_regulation E2F4 IFI27 9096690 422575 Although HL-AS5 and HL-60/V2 cells did not exhibit obvious differences in the phosphorylation status of the retinoblastoma protein ( pRB ) , in [E2F] complex formation , or in *induction* following PMA exposure , inhibition of activity of cyclin dependent kinase-2 was attenuated in the antisense expressing line . Positive_regulation E2F4 MAP2K6 23919615 2826239 Treatment of quiescent HIEC with serum *induced* ERK1/2 activation , E2F4 phosphorylation , [E2F4] nuclear translocation and G1/S phase transition while inhibition of signaling by U0126 prevented these events . Positive_regulation E2F4 MAP2K6 23919615 2826259 The present results indicate that activation and GSK3 inhibition are both *required* for [E2F4] phosphorylation as well as its nuclear translocation and S phase entry in HIEC . Positive_regulation E2F5 CCND1 7970707 280103 *Activation* of the [E2F] transcription factor by is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation E2F5 CCND1 7970707 280132 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Positive_regulation E2F5 EPHB2 11371570 834851 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and and *activation* of cAMP-responsive element binding protein ( CREB ) , NF-kappaB , and [E2F] ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation E2F5 IFI27 9096690 422577 Although HL-AS5 and HL-60/V2 cells did not exhibit obvious differences in the phosphorylation status of the retinoblastoma protein ( pRB ) , in [E2F] complex formation , or in *induction* following PMA exposure , inhibition of activity of cyclin dependent kinase-2 was attenuated in the antisense expressing line . Positive_regulation E2F6 CCND1 7970707 280105 *Activation* of the [E2F] transcription factor by is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation E2F6 CCND1 7970707 280133 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Positive_regulation E2F6 EPHB2 11371570 834852 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and and *activation* of cAMP-responsive element binding protein ( CREB ) , NF-kappaB , and [E2F] ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation E2F6 IFI27 9096690 422579 Although HL-AS5 and HL-60/V2 cells did not exhibit obvious differences in the phosphorylation status of the retinoblastoma protein ( pRB ) , in [E2F] complex formation , or in *induction* following PMA exposure , inhibition of activity of cyclin dependent kinase-2 was attenuated in the antisense expressing line . Positive_regulation E2F7 CCND1 7970707 280089 *Activation* of the [E2F] transcription factor by is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation E2F7 CCND1 7970707 280126 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Positive_regulation E2F7 EPHB2 11371570 834845 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and and *activation* of cAMP-responsive element binding protein ( CREB ) , NF-kappaB , and [E2F] ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation E2F7 IFI27 9096690 422565 Although HL-AS5 and HL-60/V2 cells did not exhibit obvious differences in the phosphorylation status of the retinoblastoma protein ( pRB ) , in [E2F] complex formation , or in *induction* following PMA exposure , inhibition of activity of cyclin dependent kinase-2 was attenuated in the antisense expressing line . Positive_regulation E2F8 CCND1 7970707 280091 *Activation* of the [E2F] transcription factor by is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation E2F8 CCND1 7970707 280127 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Positive_regulation E2F8 EPHB2 11371570 834846 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and and *activation* of cAMP-responsive element binding protein ( CREB ) , NF-kappaB , and [E2F] ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation E2F8 IFI27 9096690 422567 Although HL-AS5 and HL-60/V2 cells did not exhibit obvious differences in the phosphorylation status of the retinoblastoma protein ( pRB ) , in [E2F] complex formation , or in *induction* following PMA exposure , inhibition of activity of cyclin dependent kinase-2 was attenuated in the antisense expressing line . Positive_regulation EAF1 TNF 10736094 679351 Using neutralization with an anti TNF-alpha MoAb MAK195 , [EAF] is not identical with TNF-alpha , but *induces* the expression of endothelial , since MAK195 blocked TEM only when coincubated with EC , not with monocytes . Positive_regulation EAF2 TNF 10736094 679352 Using neutralization with an anti TNF-alpha MoAb MAK195 , [EAF] is not identical with TNF-alpha , but *induces* the expression of endothelial , since MAK195 blocked TEM only when coincubated with EC , not with monocytes . Positive_regulation EBAG9 GPR115 20079734 2264726 [RCAS1] secretion was strongly *suppressed* by inhibitors of metalloproteases , protein kinase C (PKC)-delta , mitogen activated protein kinase (MAPK)/extracellular signal regulated kinase kinase ( MEK ) , epidermal growth factor (EGF) , and . Positive_regulation EBAG9 GPR132 20079734 2264715 [RCAS1] secretion was strongly *suppressed* by inhibitors of metalloproteases , protein kinase C (PKC)-delta , mitogen activated protein kinase (MAPK)/extracellular signal regulated kinase kinase ( MEK ) , epidermal growth factor (EGF) , and . Positive_regulation EBAG9 GPR87 20079734 2264797 [RCAS1] secretion was strongly *suppressed* by inhibitors of metalloproteases , protein kinase C (PKC)-delta , mitogen activated protein kinase (MAPK)/extracellular signal regulated kinase kinase ( MEK ) , epidermal growth factor (EGF) , and . Positive_regulation EBF3 TF 8297471 240919 In the uterus alone , [OE2] produced a significant increase in the content of nucleic acids and also *induced* the accumulation of and beta-actin mRNAs . Positive_regulation EBI3 TLR7 15728491 1377261 In summary , these data suggest that [EBI3] expression in DCs is transcriptionally *regulated* by signaling via MyD88 and NF-kappaB . Positive_regulation EBI3 TLR7 15728491 1377291 Thus , [EBI3] gene transcription in DCs is *induced* rapidly by signaling during innate immune responses preceding cytokine driven Th cell development . Positive_regulation EBP IL1B 11399097 823941 NIM had no effect on ( 1 ) *induced* increases in NF-kappaB or [c/EBP] signaling , or ( 2 ) human COX-2 promoter activity . Positive_regulation EBP IL1B 12034569 948742 *induces* DNA binding of both nuclear factor kappaB (NF-kappaB) and [CAATT-enhancer binding protein (C/EBP)] , and activation of p38 mitogen activated protein kinase in both subpopulations . Positive_regulation EBP IL1B 16569740 1568491 OTR promoter contains putative transcription factor binding sites for activating protein-1 (AP-1) , [CCAAT/enhancer binding protein (C/EBP)] , and nuclear factor-kappaB (NF-kappaB) , which may be *activated* by , whose concentrations increase with labor . Positive_regulation ECE1 EPHB2 18753413 1956393 In addition , inhibition of activation in stellate cells from BDL injured liver *led* to a decrease in expression of [endothelin converting enzyme-1] , a critical regulator of endothelin-1 . Positive_regulation ECE1 MAP2K6 11723240 884153 The inhibitor of , PD98059 , *inhibited* PMA effects on [ECE-1a] mRNA expression and promoter activity , respectively . Positive_regulation ECE1 TNF 11775854 581307 *induced* [ECE-mRNA] expression and ET-1 release from above cultured cells were determined by RT-PCR and ELISA . Positive_regulation ECE1 TNF 9032126 414765 *resulted* in a significant increase in [ECE-1] mRNA expression . Positive_regulation ECM1 CTGF 12218048 1012114 The role of p42/44 MAPK and protein kinase B in *induced* [extracellular matrix protein] production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Positive_regulation ECM1 CTGF 15579446 1344855 is a potent *inducer* of [ECM] synthesis and increases in the diabetic kidneys . Positive_regulation ECM1 CTGF 15579446 1344859 To determine the critical *role* of in AGE induced [ECM] accumulation leading to diabetic nephropathy , rats were given AGEs by intravenous injection for 6 weeks . Positive_regulation ECM1 CTGF 15976312 1434717 In vascular smooth muscle cells ( VSMCs ) , *regulates* cell proliferation/apoptosis , migration , and [extracellular matrix (ECM)] accumulation . Positive_regulation ECM1 CTGF 16528248 1536311 In all cases , the *induced* increase in [ECM] protein was inhibited in the presence of tranilast . Positive_regulation ECM1 CTGF 16682975 1569952 Transforming growth factor-beta ( TGF-beta ) is the most potent fibrogenic cytokine while *mediates* the production of TGF-beta induced [ECM] in activated HSC . Positive_regulation ECM1 CTGF 17393107 1716261 In order to investigate the effects of connective tissue growth factor (CTGF) antisense oligodeoxynucleotide ( ODN ) on plasminogen activator inhibitor-1 ( PAI-1 ) expression in renal tubular cells induced by transforming growth factor beta1 ( TGF-beta1 ) and to explore the *role* of in the degradation of renal [extracellular matrix (ECM)] , a human proximal tubular epithelial cell line ( HKC ) was cultured in vitro . Positive_regulation ECM1 CTGF 18369694 1888215 These findings indicate that is *involved* in [ECM] production in SCFs activated by exogenous TGFbeta1 in vitro . Positive_regulation ECM1 CTGF 18433392 1900204 Our data suggest that shRNA mediated disruption of expression can *attenuate* [ECM] synthesis . Positive_regulation ECM1 CTGF 18471259 1910370 The above results indicate that *triggers* cell proliferation and production of [ECM] proteins in cultured myofibroblast-like cells through the ERK1/2 mitogen activated protein kinase pathway . Positive_regulation ECM1 CTGF 18784153 1963307 In vivo , over-expression of *causes* [ECM] accumulation and promotes tissue fibrosis . Positive_regulation ECM1 CTGF 19111553 2031724 In different cell types *regulates* cell proliferation/apoptosis , migration , and [extracellular matrix (ECM)] accumulation and plays important roles in angiogenesis , chondrogenesis , osteogenesis , tissue repair , cancer and fibrosis . Positive_regulation ECM1 CTGF 20522804 2295369 stimulation *enhanced* [extracellular matrix protein] expression by cardiac fibroblasts in a Smad3 independent manner . Positive_regulation ECM1 CTGF 21642622 2455002 This gremlin induction of [ECM] genes and protein expression was *blocked* by inhibitors of TGFBR and the canonical Smad2/3/4 and signaling pathways . Positive_regulation ECM1 CTGF 21645240 2579209 ( CTGF/CCN-2 ) is mainly *involved* in the induction of [extracellular matrix (ECM)] proteins . Positive_regulation ECM1 CTGF 22280508 2545405 TGF-ß/Smad-3 independent up-regulation of may *induce* accumulation of [ECM] proteins and maintain fibrosis in chronic LS . Positive_regulation ECM1 CTGF 24302644 2899132 was among a small group of genes regulated by the amount of cyclic shortening regardless of the level of mean stretch , and many more [ECM] genes were *regulated* by shortening with reduced amounts of stretch . Positive_regulation ECM1 CTGF 24392320 2883990 TGF-ß2 and could *induce* HLECs epithelial mesenchymal transition and [ECM] synthesis . Positive_regulation ECM1 EDN2 9736248 531250 and bradykinin also *stimulate* cell proliferation and [ECM] synthesis in RMICs through ET ( A ) and B2 receptors , respectively , but the actions of endothelin are modulated by concurrent nitric oxide production . Positive_regulation ECM1 FOXA1 1875930 165494 Enhancer activation by the [ECM] was *mediated* by two liver transcription factors , and eH-TF , which appear to be regulated differently by matrix . Positive_regulation ECM1 HBEGF 23146907 2848494 Imatinib stimulated shedding of the EGFR ligand heparin binding EGF-like growth factor ( HB-EGF ) from HNSCC cells , where soluble *enhanced* invadopodia [ECM] degradation in HNSCC but not in MDA-MB-231 . Positive_regulation ECM1 IL1B 10868970 706652 Glomerular mRNA synthesis was also enhanced as early as day 1 and could be *involved* in the increase in [ECM] and adhesion molecule gene expressions . Positive_regulation ECM1 IL1B 11717194 881916 In terms of ECM expression , adenosine and the adenosine receptor agonists , 2-CADO and CPA , enhanced constitutive and *induced* expression of hyaluronate synthase mRNA , but not the mRNA levels of other [ECM] , such as collagen type I , III and fibronectin . Positive_regulation ECM1 IL1B 15598420 1356637 These findings suggest that hypoxia and may *contribute* to the degradation or remodelling of the [extracellular matrix (ECM)] of the disc and may have a role in the pathogenesis of TMJ disorders . Positive_regulation ECM1 IL1B 17512021 1751156 In conclusion , emodin suppresses *induced* MC proliferation and [ECM] production in vitro . Positive_regulation ECM1 MMP28 10849774 701306 are *involved* in degradation of the [extracellular matrix (ECM)] . Positive_regulation ECM1 MMP28 11014984 736419 These results show that decreased activities *cause* abnormal accumulation of [ECM] in ICGN mouse kidneys . Positive_regulation ECM1 MMP28 11870075 918366 Increased activity may *promote* [ECM] degradation during luteolysis . Positive_regulation ECM1 MMP28 12180853 977369 In vivo , a hydramate based inhibitor *attenuated* excess mesangial cell proliferation and [ECM] accumulation in anti-Thy1.1 nephritis . Positive_regulation ECM1 MMP28 12956410 1137737 We conclude that reduced levels could *lead* to increased [ECM] accumulation and thus contribute to early vascular lesion formation . Positive_regulation ECM1 MMP28 15920147 1413593 Our results strongly suggest that overexpression may *contribute* to an excessive degradation of tumor [ECM] and increase the risk of embolism in cardiac myxomas . Positive_regulation ECM1 MMP28 16762015 1572122 Expression of MT1-MMP , RECK and EMMPRIN in tooth germs and ameloblastic tumors suggests that these normal and neoplastic epithelial components control *dependent* [extracellular matrix (ECM)] degradation during tooth development and tumor progression via epithelial-mesenchymal interactions . Positive_regulation ECM1 MMP28 19128402 2019622 We propose that increased activity in the absence of TIMP3 *enhances* [ECM] proteolysis , upsetting proper formation of primitive alveolar septa during the saccular stage of alveologenesis . Positive_regulation ECM1 MMP28 19379669 2065664 Overexpression of in MDCK cells *resulted* in a drastic reduction of basolateral [ECM] , as observed by the disappearance of collagen type IV , laminin and fibronectin . Positive_regulation ECM1 MMP28 21920495 2567692 We provide evidence that HSC-3 OSCC has a tendency to adopt invadopodia for invasion and accompanying *dependent* proteolytic [ECM] degradation and EGFR signalling is necessary for invadopodia formation and associated ECM degradation activity . Positive_regulation ECM1 MMP7 10849774 701321 are *involved* in degradation of the [extracellular matrix (ECM)] . Positive_regulation ECM1 MMP7 11014984 736434 These results show that decreased activities *cause* abnormal accumulation of [ECM] in ICGN mouse kidneys . Positive_regulation ECM1 MMP7 11870075 918381 Increased activity may *promote* [ECM] degradation during luteolysis . Positive_regulation ECM1 MMP7 12180853 977384 In vivo , a hydramate based inhibitor *attenuated* excess mesangial cell proliferation and [ECM] accumulation in anti-Thy1.1 nephritis . Positive_regulation ECM1 MMP7 12956410 1137752 We conclude that reduced levels could *lead* to increased [ECM] accumulation and thus contribute to early vascular lesion formation . Positive_regulation ECM1 MMP7 15920147 1413608 Our results strongly suggest that overexpression may *contribute* to an excessive degradation of tumor [ECM] and increase the risk of embolism in cardiac myxomas . Positive_regulation ECM1 MMP7 16762015 1572137 Expression of MT1-MMP , RECK and EMMPRIN in tooth germs and ameloblastic tumors suggests that these normal and neoplastic epithelial components control *dependent* [extracellular matrix (ECM)] degradation during tooth development and tumor progression via epithelial-mesenchymal interactions . Positive_regulation ECM1 MMP7 19128402 2019637 We propose that increased activity in the absence of TIMP3 *enhances* [ECM] proteolysis , upsetting proper formation of primitive alveolar septa during the saccular stage of alveologenesis . Positive_regulation ECM1 MMP7 21920495 2567708 We provide evidence that HSC-3 OSCC has a tendency to adopt invadopodia for invasion and accompanying *dependent* proteolytic [ECM] degradation and EGFR signalling is necessary for invadopodia formation and associated ECM degradation activity . Positive_regulation ECM1 PLAT 16038272 1437341 To study the *role* of plasminogen activator inhibitor-1 ( PAI-1 ) and in the accumulation of [extracellular matrix (ECM)] in the kidney of KKAy mice with type 2 diabetes . Positive_regulation ECM1 PLAU 12784997 1096663 Secondly , *regulates* [cell/ECM] interactions as an adhesion receptor for vitronectin (Vn) and through its capacity to modulate integrin function . Positive_regulation ECM1 PLAU 15257104 1272329 Tumor associated trypsinogen (TAT) , ( u-PA ) , matrix metalloproteinase-2 (MMP-2) , and MMP-9 each play a dominant *role* in the degradation of [extracellular matrix (ECM)] during the invasion process of pancreatic cancer . Positive_regulation ECM1 PLAU 17625304 1770139 Tumor associated trypsinogen , , matrix metalloprotease-2 (MMP-2) , and MMP-9 each play a dominant *role* in the degradation of the [extracellular matrix (ECM)] during the invasion process of pancreatic cancer . Positive_regulation ECM1 PLAU 19181000 2007121 Herein we have focused on the *role* of ( uPA ) and transforming growth factor beta 1 ( TGF/1 ) in [ECM] degradation and reconstitution in muscles . Positive_regulation ECM1 PLAU 22137664 2579603 *mediate* the [extracellular matrix (ECM)] degradation , and plays a pivotal role in cell adhesion , migration and proliferation , during tissue remodeling . Positive_regulation ECM1 PLAU 7906155 240342 TNF alpha treatment of human umbilical vein endothelial ( HUVE ) cells induced urokinase-type plasminogen (uPA) activity , increased HUVE *dependent* [extracellular matrix (ECM)] degradation , and accelerated matrix remodeling and endothelial differentiation into tubes or cord-like structures . Positive_regulation ECM1 S1PR3 23589284 2789514 The strong induction of ECM synthesis by the nonselective agonists S1P and FTY720-P was due to the stimulation of S1P2 and S1P3 receptors , whereas the weaker induction of [ECM] synthesis at high concentrations of ponesimod was *due* to a low potency activation of receptors . Positive_regulation ECM1 TGM2 16936095 1608918 In the present study , the *role* of in the accumulation of [extracellular matrix (ECM)] proteins in these scars was investigated . Positive_regulation ECM1 TGM2 18235007 1864351 It is possible that the increase in [ECM] proteins in the glaucomatous TM is *due* to increased cross linking activity of . Positive_regulation ECM1 TLR7 21199160 2386151 RV infection and ligands promote ECM deposition in isolated cell systems and RV *induces* [ECM] gene expression in vivo , thus demonstrating that RV has the potential to contribute to remodelling of the airways through induction of ECM deposition . Positive_regulation ECM1 TNF 12082286 958525 By analogy , an inhibitor to the p55 TNF-alpha receptor may also provide a mechanism for abolishing *induced* degradation of cartilage [ECM] by MMPs . Positive_regulation ECM1 TNF 15723438 1376704 *promoted* an [extracellular matrix (ECM)] degradation that involved the matrix metalloproteinase MMP-9 induction through activation of NF-kappaB pathway . Positive_regulation ECM1 TNF 8896174 392662 The U937 cells markedly adhered to the *stimulated* human umbilical vein endothelial cells ( HUVECs ) and also to the [extracellular matrix protein] , fibronectin , but mNI-58A did not enhance or block these adhesion process . Positive_regulation ECM1 TNF 9755095 535333 With PSOC 867 exposure , where ECM protein synthesis is elevated , and TGF-beta1 further *increased* both the absolute and relative rates of [ECM] synthesis on day 3 but had little effect on day 1 . Positive_regulation ECM1 TNS1 10704455 672874 Tensin is a primary cytoskeletal component of these ECM contacts , and a novel dominant negative inhibitor of *blocked* [ECM] contact formation , integrin translocation , and fibronectin fibrillogenesis without affecting focal contacts . Positive_regulation ECM2 CTGF 12218048 1012115 The role of p42/44 MAPK and protein kinase B in *induced* [extracellular matrix protein] production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Positive_regulation ECM2 CTGF 15579446 1344856 is a potent *inducer* of [ECM] synthesis and increases in the diabetic kidneys . Positive_regulation ECM2 CTGF 15579446 1344861 To determine the critical *role* of in AGE induced [ECM] accumulation leading to diabetic nephropathy , rats were given AGEs by intravenous injection for 6 weeks . Positive_regulation ECM2 CTGF 15976312 1434718 In vascular smooth muscle cells ( VSMCs ) , *regulates* cell proliferation/apoptosis , migration , and [extracellular matrix (ECM)] accumulation . Positive_regulation ECM2 CTGF 16528248 1536312 In all cases , the *induced* increase in [ECM] protein was inhibited in the presence of tranilast . Positive_regulation ECM2 CTGF 16682975 1569953 Transforming growth factor-beta ( TGF-beta ) is the most potent fibrogenic cytokine while *mediates* the production of TGF-beta induced [ECM] in activated HSC . Positive_regulation ECM2 CTGF 17393107 1716262 In order to investigate the effects of connective tissue growth factor (CTGF) antisense oligodeoxynucleotide ( ODN ) on plasminogen activator inhibitor-1 ( PAI-1 ) expression in renal tubular cells induced by transforming growth factor beta1 ( TGF-beta1 ) and to explore the *role* of in the degradation of renal [extracellular matrix (ECM)] , a human proximal tubular epithelial cell line ( HKC ) was cultured in vitro . Positive_regulation ECM2 CTGF 18369694 1888216 These findings indicate that is *involved* in [ECM] production in SCFs activated by exogenous TGFbeta1 in vitro . Positive_regulation ECM2 CTGF 18433392 1900205 Our data suggest that shRNA mediated disruption of expression can *attenuate* [ECM] synthesis . Positive_regulation ECM2 CTGF 18471259 1910371 The above results indicate that *triggers* cell proliferation and production of [ECM] proteins in cultured myofibroblast-like cells through the ERK1/2 mitogen activated protein kinase pathway . Positive_regulation ECM2 CTGF 18784153 1963308 In vivo , over-expression of *causes* [ECM] accumulation and promotes tissue fibrosis . Positive_regulation ECM2 CTGF 19111553 2031725 In different cell types *regulates* cell proliferation/apoptosis , migration , and [extracellular matrix (ECM)] accumulation and plays important roles in angiogenesis , chondrogenesis , osteogenesis , tissue repair , cancer and fibrosis . Positive_regulation ECM2 CTGF 20522804 2295370 stimulation *enhanced* [extracellular matrix protein] expression by cardiac fibroblasts in a Smad3 independent manner . Positive_regulation ECM2 CTGF 21642622 2455009 This gremlin induction of [ECM] genes and protein expression was *blocked* by inhibitors of TGFBR and the canonical Smad2/3/4 and signaling pathways . Positive_regulation ECM2 CTGF 21645240 2579210 Connective tissue growth factor ( ) is mainly *involved* in the induction of [extracellular matrix (ECM)] proteins . Positive_regulation ECM2 CTGF 22280508 2545406 TGF-ß/Smad-3 independent up-regulation of may *induce* accumulation of [ECM] proteins and maintain fibrosis in chronic LS . Positive_regulation ECM2 CTGF 24302644 2899133 was among a small group of genes regulated by the amount of cyclic shortening regardless of the level of mean stretch , and many more [ECM] genes were *regulated* by shortening with reduced amounts of stretch . Positive_regulation ECM2 CTGF 24392320 2883991 TGF-ß2 and could *induce* HLECs epithelial mesenchymal transition and [ECM] synthesis . Positive_regulation ECM2 EDN2 9736248 531253 and bradykinin also *stimulate* cell proliferation and [ECM] synthesis in RMICs through ET ( A ) and B2 receptors , respectively , but the actions of endothelin are modulated by concurrent nitric oxide production . Positive_regulation ECM2 FOXA1 1875930 165495 Enhancer activation by the [ECM] was *mediated* by two liver transcription factors , and eH-TF , which appear to be regulated differently by matrix . Positive_regulation ECM2 HBEGF 23146907 2848495 Imatinib stimulated shedding of the EGFR ligand heparin binding EGF-like growth factor ( HB-EGF ) from HNSCC cells , where soluble *enhanced* invadopodia [ECM] degradation in HNSCC but not in MDA-MB-231 . Positive_regulation ECM2 IL1B 10868970 706653 Glomerular mRNA synthesis was also enhanced as early as day 1 and could be *involved* in the increase in [ECM] and adhesion molecule gene expressions . Positive_regulation ECM2 IL1B 11717194 881917 In terms of ECM expression , adenosine and the adenosine receptor agonists , 2-CADO and CPA , enhanced constitutive and *induced* expression of hyaluronate synthase mRNA , but not the mRNA levels of other [ECM] , such as collagen type I , III and fibronectin . Positive_regulation ECM2 IL1B 15598420 1356638 These findings suggest that hypoxia and may *contribute* to the degradation or remodelling of the [extracellular matrix (ECM)] of the disc and may have a role in the pathogenesis of TMJ disorders . Positive_regulation ECM2 IL1B 17512021 1751157 In conclusion , emodin suppresses *induced* MC proliferation and [ECM] production in vitro . Positive_regulation ECM2 MMP28 10849774 701328 are *involved* in degradation of the [extracellular matrix (ECM)] . Positive_regulation ECM2 MMP28 11014984 736441 These results show that decreased activities *cause* abnormal accumulation of [ECM] in ICGN mouse kidneys . Positive_regulation ECM2 MMP28 11870075 918388 Increased activity may *promote* [ECM] degradation during luteolysis . Positive_regulation ECM2 MMP28 12180853 977391 In vivo , a hydramate based inhibitor *attenuated* excess mesangial cell proliferation and [ECM] accumulation in anti-Thy1.1 nephritis . Positive_regulation ECM2 MMP28 12956410 1137759 We conclude that reduced levels could *lead* to increased [ECM] accumulation and thus contribute to early vascular lesion formation . Positive_regulation ECM2 MMP28 15920147 1413615 Our results strongly suggest that overexpression may *contribute* to an excessive degradation of tumor [ECM] and increase the risk of embolism in cardiac myxomas . Positive_regulation ECM2 MMP28 16762015 1572144 Expression of MT1-MMP , RECK and EMMPRIN in tooth germs and ameloblastic tumors suggests that these normal and neoplastic epithelial components control *dependent* [extracellular matrix (ECM)] degradation during tooth development and tumor progression via epithelial-mesenchymal interactions . Positive_regulation ECM2 MMP28 19128402 2019644 We propose that increased activity in the absence of TIMP3 *enhances* [ECM] proteolysis , upsetting proper formation of primitive alveolar septa during the saccular stage of alveologenesis . Positive_regulation ECM2 MMP28 19379669 2065665 Overexpression of in MDCK cells *resulted* in a drastic reduction of basolateral [ECM] , as observed by the disappearance of collagen type IV , laminin and fibronectin . Positive_regulation ECM2 MMP28 21920495 2567715 We provide evidence that HSC-3 OSCC has a tendency to adopt invadopodia for invasion and accompanying *dependent* proteolytic [ECM] degradation and EGFR signalling is necessary for invadopodia formation and associated ECM degradation activity . Positive_regulation ECM2 MMP7 10849774 701343 are *involved* in degradation of the [extracellular matrix (ECM)] . Positive_regulation ECM2 MMP7 11014984 736456 These results show that decreased activities *cause* abnormal accumulation of [ECM] in ICGN mouse kidneys . Positive_regulation ECM2 MMP7 11870075 918403 Increased activity may *promote* [ECM] degradation during luteolysis . Positive_regulation ECM2 MMP7 12180853 977406 In vivo , a hydramate based inhibitor *attenuated* excess mesangial cell proliferation and [ECM] accumulation in anti-Thy1.1 nephritis . Positive_regulation ECM2 MMP7 12956410 1137774 We conclude that reduced levels could *lead* to increased [ECM] accumulation and thus contribute to early vascular lesion formation . Positive_regulation ECM2 MMP7 15920147 1413630 Our results strongly suggest that overexpression may *contribute* to an excessive degradation of tumor [ECM] and increase the risk of embolism in cardiac myxomas . Positive_regulation ECM2 MMP7 16762015 1572159 Expression of MT1-MMP , RECK and EMMPRIN in tooth germs and ameloblastic tumors suggests that these normal and neoplastic epithelial components control *dependent* [extracellular matrix (ECM)] degradation during tooth development and tumor progression via epithelial-mesenchymal interactions . Positive_regulation ECM2 MMP7 19128402 2019659 We propose that increased activity in the absence of TIMP3 *enhances* [ECM] proteolysis , upsetting proper formation of primitive alveolar septa during the saccular stage of alveologenesis . Positive_regulation ECM2 MMP7 21920495 2567731 We provide evidence that HSC-3 OSCC has a tendency to adopt invadopodia for invasion and accompanying *dependent* proteolytic [ECM] degradation and EGFR signalling is necessary for invadopodia formation and associated ECM degradation activity . Positive_regulation ECM2 PLAT 16038272 1437343 To study the *role* of plasminogen activator inhibitor-1 ( PAI-1 ) and in the accumulation of [extracellular matrix (ECM)] in the kidney of KKAy mice with type 2 diabetes . Positive_regulation ECM2 PLAU 12784997 1096665 Secondly , *regulates* [cell/ECM] interactions as an adhesion receptor for vitronectin (Vn) and through its capacity to modulate integrin function . Positive_regulation ECM2 PLAU 15257104 1272332 Tumor associated trypsinogen (TAT) , ( u-PA ) , matrix metalloproteinase-2 (MMP-2) , and MMP-9 each play a dominant *role* in the degradation of [extracellular matrix (ECM)] during the invasion process of pancreatic cancer . Positive_regulation ECM2 PLAU 17625304 1770142 Tumor associated trypsinogen , , matrix metalloprotease-2 (MMP-2) , and MMP-9 each play a dominant *role* in the degradation of the [extracellular matrix (ECM)] during the invasion process of pancreatic cancer . Positive_regulation ECM2 PLAU 19181000 2007123 Herein we have focused on the *role* of ( uPA ) and transforming growth factor beta 1 ( TGF/1 ) in [ECM] degradation and reconstitution in muscles . Positive_regulation ECM2 PLAU 22137664 2579604 *mediate* the [extracellular matrix (ECM)] degradation , and plays a pivotal role in cell adhesion , migration and proliferation , during tissue remodeling . Positive_regulation ECM2 PLAU 7906155 240343 TNF alpha treatment of human umbilical vein endothelial ( HUVE ) cells induced urokinase-type plasminogen (uPA) activity , increased HUVE *dependent* [extracellular matrix (ECM)] degradation , and accelerated matrix remodeling and endothelial differentiation into tubes or cord-like structures . Positive_regulation ECM2 S1PR3 23589284 2789516 The strong induction of [ECM] synthesis by the nonselective agonists S1P and FTY720-P was *due* to the stimulation of S1P2 and receptors , whereas the weaker induction of ECM synthesis at high concentrations of ponesimod was due to a low potency activation of S1P3 receptors . Positive_regulation ECM2 TGM2 16936095 1608919 In the present study , the *role* of in the accumulation of [extracellular matrix (ECM)] proteins in these scars was investigated . Positive_regulation ECM2 TGM2 18235007 1864352 It is possible that the increase in [ECM] proteins in the glaucomatous TM is *due* to increased cross linking activity of . Positive_regulation ECM2 TLR7 21199160 2386161 RV infection and ligands promote ECM deposition in isolated cell systems and RV *induces* [ECM] gene expression in vivo , thus demonstrating that RV has the potential to contribute to remodelling of the airways through induction of ECM deposition . Positive_regulation ECM2 TNF 12082286 958526 By analogy , an inhibitor to the p55 TNF-alpha receptor may also provide a mechanism for abolishing *induced* degradation of cartilage [ECM] by MMPs . Positive_regulation ECM2 TNF 15723438 1376706 *promoted* an [extracellular matrix (ECM)] degradation that involved the matrix metalloproteinase MMP-9 induction through activation of NF-kappaB pathway . Positive_regulation ECM2 TNF 8896174 392663 The U937 cells markedly adhered to the *stimulated* human umbilical vein endothelial cells ( HUVECs ) and also to the [extracellular matrix protein] , fibronectin , but mNI-58A did not enhance or block these adhesion process . Positive_regulation ECM2 TNF 9755095 535335 With PSOC 867 exposure , where ECM protein synthesis is elevated , and TGF-beta1 further *increased* both the absolute and relative rates of [ECM] synthesis on day 3 but had little effect on day 1 . Positive_regulation ECM2 TNS1 10704455 672875 Tensin is a primary cytoskeletal component of these ECM contacts , and a novel dominant negative inhibitor of *blocked* [ECM] contact formation , integrin translocation , and fibronectin fibrillogenesis without affecting focal contacts . Positive_regulation EDAR CTGF 16769906 1572603 [Edar] activation also *induces* , an inhibitor of BMP signaling , allowing BMP action only at a distance from their site of synthesis . Positive_regulation EDIL3 TNF 15964546 1428222 In addition , mouse recombinant interleukin-1alpha and also *induced* [Del1] in MLE cells . Positive_regulation EDN1 ALOX5 12531730 1064170 The <5-lipoxygenase (5-LO)> inhibitor AA-861 and the CysLT(1)-selective antagonist MK-571 *reduced* the maximal [ Ca ( 2+ ) ] ( i ) responses to ANG II but not to vasopressin and [endothelin-1] . Positive_regulation EDN1 ANGPT1 16917117 1632854 added to P-ECs from patients with iPAH *increased* the production of [endothelin-1 (ET-1)] and serotonin , but not of platelet derived growth factor-BB or epidermal growth factor , and increased the amount of mRNA encoding tryptophan hydroxylase-1 ( the rate limiting enzyme of serotonin synthesis ) , preproET-1 , and ET-1 converting enzyme . Positive_regulation EDN1 CTGF 19111553 2031723 [Endothelin-1] *induces* expression in cardiomyocytes . Positive_regulation EDN1 CTGF 19111553 2031731 Moreover , in cells treated with ET-1 the expression of ECM component decorin was abolished by CTGF silencing , indicating that is *involved* in [ET-1] induced ECM accumulation not only in a direct manner but also through downstream effectors . Positive_regulation EDN1 CTGF 22365964 2681262 Expression of , tumor growth factor-ß , collagen I and III in response to AngII *required* endothelial [ET-1] . Positive_regulation EDN1 CTGF 24486572 2923616 [Endothelin-1] *induces* expression in human lung fibroblasts by ETAR dependent JNK/AP-1 pathway . Positive_regulation EDN1 CTGF 24486572 2923626 These results suggest that [ET-1] stimulates expressions of CTGF and a-SMA through ETAR/JNK/AP-1 signaling pathway , and is *required* for ET-1 induced a-SMA expression in human lung fibroblasts . Positive_regulation EDN1 EDN2 10673066 667334 This result , together with the findings that plasma and hepatic levels were elevated in cirrhotic rats and that exogenous [endothelin-1] *increased* portal pressure , provides further support for a role of endothelin in portal hypertension and suggests a potential use of mixed endothelin antagonist in the pharmacological treatment of portal hypertension . Positive_regulation EDN1 EDN2 10774165 686451 Previous studies suggested that [ET-1] can act as a vasoconstrictor via the endothelin-A and -B 2 receptors located on smooth muscle cells , and also *act* as a vasodilator through the 1 receptor situated on endothelial cells in the pulmonary circulation . Positive_regulation EDN1 EDN2 11214636 763897 is a family of potent vasoconstrictive peptides , and [endothelin-1 (ET-1)] produced in the endothelium *induces* a tonic contraction via specific receptor ET ( A ) . Positive_regulation EDN1 EDN2 11414314 828930 However , ET-3 induced damaging effects are less pronounced , while [ET-1] most severely alters microcirculation and preferentially *induces* leukocyte dependent inflammation . Positive_regulation EDN1 EDN2 12372435 996416 We observed through real-time PCR analysis that ET-1 and gene expression gradually *increase* after parturition and that [ET-1] gene expression is significantly higher than that of VIC/ET-2 . Positive_regulation EDN1 EDN2 15998353 1430386 Unexpected , [endothelin-1] *induced* an ( A ) mediated vasodilation . Positive_regulation EDN1 EDN2 17660396 1799078 Altered *role* of smooth muscle receptors in coronary [endothelin-1] and alpha1-adrenoceptor mediated vasoconstriction in Type 2 diabetes . Positive_regulation EDN1 EDN2 20625315 2327846 [Endothelin-1] stimulation of proteoglycan synthesis in vascular smooth muscle is *mediated* by receptor transactivation of the transforming growth factor-[beta ] type I receptor . Positive_regulation EDN1 EDN2 21515378 2449060 [ET-1] induced Elevation of intracellular calcium in clonal neuronal and embryonic kidney cells *involves* endogenous receptors linked to phospholipase C through Ga ( q/11 ) . Positive_regulation EDN1 EDN2 22492044 2583537 One involves SFO dependent activation of the paraventricular hypothalamic nucleus , elevations in plasma vasopressin , upregulation of [endothelin-1] in cerebral resistance arterioles and *activation* of type A receptors . Positive_regulation EDN1 EDN2 23256109 2709077 [Endothelin-1 (ET-1)] seems to enhance the pro-fibrotic protein synthesis by skin fibroblasts and its effects are *mediated* by and B ( ETA and ETB ) receptors . Positive_regulation EDN1 EDN2 8198971 259432 [ET-1] was *detected* in 11 of 12 pancreatic cancer cell lines ( 92 % ) while and ET-3 were detectable in only one cell line . Positive_regulation EDN1 EDN2 8621208 359399 Moreover , the production of appears to be regulated at the mRNA transcription level , and expressions of [ET-1] and ET-3 are *regulated* independently . Positive_regulation EDN1 EDN2 8790748 380931 Vasoconstriction became evident 30 s after administration of the endothelins , reached its maximum after 1 min and lasted 10 to 20 min . [ET-1] *induced* stronger vasconstriction than ET-2 and ET-3 at equal dosage , except at 100.0 pmol/kg , where had the same effect as ET-1 . Positive_regulation EDN1 EDN2 8991802 345070 [Endothelin-1] induced force in the saphenous and jugular veins is normally *mediated* by ETB-like receptors . Positive_regulation EDN1 EDN2 9600642 506473 The results demonstrate that [endothelin-1] binds to brush border membranes , and that ET ( B ) receptors may be *involved* in the previously described effects of endothelin-1 on brush border membrane Na+ transport . Positive_regulation EDN1 EDN2 9831916 551589 2 . [ET-1] ( 100 nM ) produced distinct NC in the presence of BQ788 ( 300 nM ) , and positive chronotropic response ( PC ) in the presence of BQ123 ( 1 microM ) in both species , showing that ETAR and ET ( B ) receptor ( ET ( B ) R ) *mediate* NC and PC , respectively . Positive_regulation EDN1 EPHB2 11158304 781091 In transfection experiments , dominant negative N17Rac1 inhibited *activation* of by [endothelin 1] , whereas activated V12Rac1 cooperated with c-Raf to activate ERK . Positive_regulation EDN1 EPHB2 11606208 871570 [Endothelin-1] stimulation of wild-type ET ( A ) or ET ( B ) *induced* a fivefold to sixfold increase in in COS-7 and CHO cells whereas full-length nonpalmitoylated ET ( A ) and ET ( B ) mutants failed to stimulate ERK . Positive_regulation EDN1 EPHB2 12475899 1037712 [Endothelin] *induced* a rapid phosphorylation of the mitogen activated protein kinase <(MAPK)/ERK> and increased collagen I gene activity in freshly isolated aortas . Positive_regulation EDN1 EPHB2 12695528 1081090 Only inhibitor U0126 could *inhibit* ET-1 induced transcription of the [ET-1] gene . Positive_regulation EDN1 EPHB2 14730203 1211799 An inhibitor , U0126 , *inhibited* Ang II-induced [ET-1] expression completely . Positive_regulation EDN1 EPHB2 16368968 1505130 *activates* [endothelin-1] , which in turn exerts positive feedback activating ERK , and cyclin D1 is a downstream target of both endothelin-1 and ERK . Positive_regulation EDN1 EPHB2 17113976 1651254 *Activation* of by both [ET-1] and EGF was abolished by inhibition of Src , indicating its central role in ET-1 signaling in BAG cells . Positive_regulation EDN1 EPHB2 18954524 1982612 Inhibition of by U0126 ( 1,4-diamino-2,3-dicyano- 1,4-bis [ 2-aminophenylthio ] butadiene ) significantly *suppressed* uric acid induced [ET-1] expression , implicating this pathway in the response to uric acid . Positive_regulation EDN1 EPHB2 19207476 2033956 We first confirmed that Ca ( 2+ ) oscillation induced by [ET-1] treatment elicits transient *activation* of CaMKII and in cultured cardiomyocytes . Positive_regulation EDN1 EPHB2 19505428 2092076 activation was *required* for fibronectin induced [endothelin-1] expression . Positive_regulation EDN1 EPHB2 19575782 2111451 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Positive_regulation EDN1 EPHB2 22553998 2631925 We investigated the effect of a TAT linked intracellular third loop of the endothelin-1 type B receptor on [endothelin-1] *activation* of . Positive_regulation EDN1 EPHB2 22553998 2631926 In the normal human pulmonary artery smooth muscle cells , the peptide marginally enhanced [endothelin-1] *activation* of . Positive_regulation EDN1 EPHB2 22553998 2631927 However , it markedly enhanced the [endothelin-1] *activation* of in the bone morphogenetic protein-2 receptor human pulmonary artery smooth muscle cells . Positive_regulation EDN1 EPHB2 22553998 2631928 While the effective concentration for [endothelin-1] *activation* of remained unchanged in the bone morphogenetic protein-2 receptor human pulmonary artery smooth muscle cells , the number of ETB receptors declined by 2/3 . Positive_regulation EDN1 EPHB2 24200956 2891728 Cholangiocyte VEGF-A expression and activation accompanied proliferation and *increased* hepatic and circulating [ET-1] levels after CBDL . Positive_regulation EDN1 EPHB2 25088996 2954078 Moreover , Ang II-enhanced ETAR expression was blunted and [ET-1] binding was *reduced* by AT1R antagonism or by inhibitors of PKC or individually . Positive_regulation EDN1 F2R 7503720 336276 [Endothelin-1] does not *induce* degradation nor change in thrombin receptor mRNA level after 2 h and 24 h of incubation . Positive_regulation EDN1 IL1B 10089138 600022 *Upregulation* of [endothelin 1] and its precursor by , TNF-alpha , and TGF-beta in the PC3 human prostate cancer cell line . Positive_regulation EDN1 IL1B 10395413 627455 Segments of human temporal artery were placed in organ culture for up to 4 days and examined for [endothelin] ET ( B ) receptor activity in the *presence* and absence of the pro-inflammatory cytokine by in vitro pharmacology and reverse transcriptase-polymerase chain reaction ( RT-PCR ) . Positive_regulation EDN1 IL1B 10764953 684165 Interferon-gamma ( 100 U/ml ) increased the immunoreactive-endothelin levels , but not immunoreactive-adrenomedullin levels , whereas ( 10 ng/ml ) *increased* immunoreactive-adrenomedullin levels , but not [immunoreactive-endothelin] levels . Positive_regulation EDN1 IL1B 11398704 823906 plus TNF-alpha *increased* release of big ET-1 and [ET-1] , to 220 % and 217 % , and lung content of peptides , to 236 % and 230 % . Positive_regulation EDN1 IL1B 11888511 920044 Mevinolin also appears to oppose the increased vascular reactivity to [ET-1] *induced* by and phospholipase A(2) suggesting that statins display some anti-inflammatory properties . Positive_regulation EDN1 IL1B 12753364 1089654 [ET-1] mRNA expression and ET-1 peptide production from HGK were *enhanced* by and tumor necrosis factor-alpha . Positive_regulation EDN1 IL1B 1445301 205190 Intracellular signal transduction for *induced* [endothelin] production in human umbilical vein endothelial cells . Positive_regulation EDN1 IL1B 1445301 205193 The authors investigated the intracellular signal transduction for *induced* [endothelin (ET)] production by endothelial cells from cultured human umbilical vein ( HUVEC ) . Positive_regulation EDN1 IL1B 18524861 1939820 , but not interleukin-6 , *enhances* renal and systemic [endothelin] production in vivo . Positive_regulation EDN1 IL1B 18524861 1939826 To test whether and IL-6 *stimulate* renal [ET-1] production and release in vivo , urine was collected from male C57BL/6 mice over 24-h periods at baseline and on days 7 and 14 of a 14-day subcutaneous infusion of IL-1beta ( 10 ng/h ) , IL-6 ( 16 ng/h ) , or vehicle . Positive_regulation EDN1 IL1B 18524861 1939828 To determine whether *stimulates* [ET-1] release via activation of NF-kappaB , inner medullary collecting duct ( IMCD-3 ) cells were incubated for 24 h with IL-1beta , and ET-1 release and NF-kappaB activation were measured ( ELISA ) . Positive_regulation EDN1 IL1B 18524861 1939829 *activated* NF-kappaB and increased [ET-1] release in a concentration dependent manner . Positive_regulation EDN1 IL1B 20512083 2270531 [ET-1] secretion of EGCs could be *stimulated* by and TNFalpha in a time and dose dependent manner , whereas IL-4 and interferon-gamma showed no effect on ET-1 production . Positive_regulation EDN1 IL1B 7729539 302162 We report that is a potent *inducer* of [endothelin] receptor expression in cultured human vascular smooth muscle cells . Positive_regulation EDN1 IL1B 8587467 341730 TNF-alpha and *caused* concentration dependent increases in [ET-1] release . Positive_regulation EDN1 IL1B 9042668 416112 We conclude that is a stimulant of airway epithelial cell growth , and its mitogenic effects are *mediated* , in part , by endogenous [endothelin-1] production . Positive_regulation EDN1 IL1B 9578518 503296 In all the experiments at various times , significantly *increased* the release of [ET-1] . Positive_regulation EDN1 IL1B 9687319 522190 Also , TNFalpha and *induced* further release of [ET-1] stimulated by LH ( p < 0.05 ) . Positive_regulation EDN1 MAP2K6 23293787 2712032 inhibition did not *prevent* the [ET-1] stimulated nitrite production contrary to our initial hypothesis ( vehicle+ET-1 : 157±13 pmol/mg pr/hr vs PD98,059+ET-1 : 305.7±24 pmol/mg pr/h , N=4 , P > 0.05 ) . Positive_regulation EDN1 MMP28 20142791 2248462 inhibition *attenuated* big [ET-1] response in both Ovx groups and aged controls , but this effect was more pronounced in aged Ovx arteries ( area under the curve reduction , 3.8 +/- 0.6 units in aged Ovx rats vs 1.5 +/- 0.5 units in young Ovx rats or 1.8 +/- 0.6 units in aged intact rats ; Positive_regulation EDN1 MMP7 20142791 2248477 inhibition *attenuated* big [ET-1] response in both Ovx groups and aged controls , but this effect was more pronounced in aged Ovx arteries ( area under the curve reduction , 3.8 +/- 0.6 units in aged Ovx rats vs 1.5 +/- 0.5 units in young Ovx rats or 1.8 +/- 0.6 units in aged intact rats ; Positive_regulation EDN1 PLAT 2125563 146734 [Endothelin-1] and -3 *induce* the release of and von Willebrand factor from endothelial cells . Positive_regulation EDN1 RGS16 18046543 1852427 Sphingosine-1-phosphate and [endothelin-1] *induce* the expression of protein in cardiac myocytes by transcriptional activation of the rgs16 gene . Positive_regulation EDN1 TLR7 19129482 2047898 Priming with the allergic mediators histamine , IL-4 , and most prominently IL-5 , augmented the *induced* IL-8 and [EDN] secretion , revealing an ability to sensitize eosinophils for TLR7 and TLR9 activation . Positive_regulation EDN1 TLR7 19559483 2121900 Furthermore , chetomin , an inhibitor of the transcription factor hypoxia-inducible factor 1alpha ( HIF-1alpha ) , prevents *mediated* secretion of [ET-1] . Positive_regulation EDN1 TNF 10089138 600021 *Upregulation* of [endothelin 1] and its precursor by IL-1beta , , and TGF-beta in the PC3 human prostate cancer cell line . Positive_regulation EDN1 TNF 10218741 608497 Stimulation of BAECs with or transforming growth factor-beta *increased* [ET-1] synthesis , and treatment of BAECs with 2-chloroadenosine or staurosporine caused concentration dependent reductions in ET-1 synthesis . Positive_regulation EDN1 TNF 10491639 646528 Furthermore , significantly *stimulated* prostaglandin E ( 2 ) and [endothelin-1] secretion by both CS and TS cells ( P < 0.05 or lower ) . Positive_regulation EDN1 TNF 10708710 673595 The p55 receptor ( CD120a ) *induces* [endothelin-1] synthesis in endothelial and epithelial cells . Positive_regulation EDN1 TNF 10708710 673597 Synthesis of the vasoconstrictor peptide [endothelin-1] by endothelial and epithelial cells is strongly *induced* by . Positive_regulation EDN1 TNF 10708710 673598 Reagents activating selectively these receptor subtypes have been used to identify which receptor *mediates* the induction of [endothelin-1] synthesis . Positive_regulation EDN1 TNF 11160849 781854 However , basal and *stimulated* [ET-1] release were largely unaffected by the ECE-1c antisense ODN despite the inhibition of ECE-1c synthesis . Positive_regulation EDN1 TNF 11398704 823905 IL-1 beta plus *increased* release of big [ET-1] and ET-1 , to 220 % and 217 % , and lung content of peptides , to 236 % and 230 % . Positive_regulation EDN1 TNF 11775854 581309 Abnormal expression of ECE mRNA may be a keypoint responsible for *induced* [ET-1] release in human ASMC ; Positive_regulation EDN1 TNF 11775854 581314 *induced* [ET-1] release and ECE mRNA expression from human ASMC are inhibited by antisense oligonucleotide of ECE . Positive_regulation EDN1 TNF 11928721 927214 PSI also suppressed *induced* [ET-1] release from ECs in a dose dependent manner . Positive_regulation EDN1 TNF 11928721 927217 Pretreatment with antioxidants , pyrrolidine dithiocarbamate and alpha-lipoic acid , both of which are known to be suppressors of NF-kappaB activation , effectively attenuated basal and *induced* [ET-1] release . Positive_regulation EDN1 TNF 12083747 958747 BAY 11-7082 significantly decreased basal and *induced* [ET-1] release from endothelial cells . Positive_regulation EDN1 TNF 12241541 989708 *induces* the synthesis of [endothelin-1 (ET-1)] , a potent vasoconstictor , by the endothelium . Positive_regulation EDN1 TNF 12588293 1059428 At lower concentrations ( 10-100 pg mL-1 ) , increases the intracellular content of LPO and GSH , *stimulates* the secretion of [ET-1] and TXA2 , but inhibits the secretion of PGI2 in endothelial cells compared with control cells . Positive_regulation EDN1 TNF 12657945 1073321 ET-1 mRNA was demonstrated in the rat pancreas , and the production of [ET-1] protein by human umbilical vein endothelial cells was *enhanced* by , thrombin , and protease activated receptor-2 activating peptide . Positive_regulation EDN1 TNF 12753364 1089653 [ET-1] mRNA expression and ET-1 peptide production from HGK were *enhanced* by interleukin-1beta and . Positive_regulation EDN1 TNF 12801985 1140888 The results of the present study provide , to our knowledge , the first direct evidence that *stimulates* PG , [ET-1] , and Ang II secretion and that up-regulation of the TNFalpha system occurs in the cow oviduct during the periovulatory period . Positive_regulation EDN1 TNF 12807444 1102032 Using an in vitro BBB model consisting of co-cultures of human primary astrocytes and brain microvascular endothelial cells ( BMVECs ) , we first investigated the expression of [ET-1] by BMVECs upon *stimulation* with , which plays an essential role in the induction and synthesis of ET-1 during systemic inflammatory responses . Positive_regulation EDN1 TNF 12871749 1112547 On the other hand , a spontaneous NO donor ( +/- ) - ( E ) -4-ethyl-2- [ ( E ) -hydroxyimino ] -5-nitro-3-hexanamide ( FK409 ) significantly attenuated the basal and *induced* [endothelin-1] production and NF-kappaB activation in endothelial cells . Positive_regulation EDN1 TNF 1510683 196568 IL-8 , and TGF beta transiently *increased* the synthesis of [ET-1] , while EGF , PDGF and GM/CSF promoted proliferation of ET-1 synthesizing cells . Positive_regulation EDN1 TNF 15144886 1247624 The effect of hypoxia ( 24 h ) on *mediated* release of [endothelin-1 (ET-1)] from human optic nerve head astrocytes ( hONAs ) and TNF-alpha- and ET-1 induced hONA proliferation was determined . Positive_regulation EDN1 TNF 15214039 1262831 Furthermore , [ET-1] *induced* and IL-6 production by FSMC , but not by BMMC , and significantly enhanced VEGF production and TGF-beta1 mRNA expression by FSMC . Positive_regulation EDN1 TNF 15652492 1364238 *induces* interleukin-8 and [endothelin-1] expression in human endothelial cells with different redox pathways . Positive_regulation EDN1 TNF 15652492 1364251 By contrast , SOD gene transfer and exogenous H ( 2 ) O ( 2 ) significantly inhibited *induced* [ET-1] mRNA expression . Positive_regulation EDN1 TNF 15652492 1364254 Thus , significantly *induces* both IL-8 and [ET-1] gene expression in HMECs possibly through different redox signaling pathways . Positive_regulation EDN1 TNF 15652492 1364260 H ( 2 ) O ( 2 ) enhances TNF-alpha induced IL-8 expression , but inhibits *induced* [ET-1] expression . Positive_regulation EDN1 TNF 1566813 186857 We found that *induced* release of [ET-1] from bovine aortic endothelial cells ( BAEC ) in a time- and concentration dependent manner . Positive_regulation EDN1 TNF 1566813 186858 When measured at 8 h , *augmented* [ET-1] release over the range 0.1-250 ng/ml ( threshold , 0.1 ng/ml ; 50 % effective dose , 1.6 +/- 1.2 ng/ml ; maximal effect , 100 ng/ml ) . Positive_regulation EDN1 TNF 1566813 186859 *increased* [ET-1] release and preproendothelin-1 mRNA content in bovine renal artery and bovine glomerular capillary endothelial cells , demonstrating that the TNF-alpha effect was evident in endothelial cells derived from a variety of sources . Positive_regulation EDN1 TNF 1566813 186860 Furthermore , augmented [ET-1] expression in *response* to was evident in bovine glomerular mesangial cells . Positive_regulation EDN1 TNF 1583403 187631 , but not IL1 , *caused* a dose dependent and time dependent increase in immunoreactive [ET-1] in the supernatants of rat mesangial cells in culture . Positive_regulation EDN1 TNF 15928030 1420656 Endothelin is also elevated in preeclampsia and [endothelin] synthesis is *enhanced* by . Positive_regulation EDN1 TNF 16018991 1465694 Ghrelin inhibited *induced* [ET-1] release from HUVECs in a dose dependent manner . Positive_regulation EDN1 TNF 16596276 1544876 We suggested that can *induce* [ET-1] mRNA expression in NSCLC , similarly to IL-8 expression . Positive_regulation EDN1 TNF 16720059 1631455 Northern blot analysis showed that [ET-1] mRNA expression levels were *increased* by alone or a combination of tumor necrosis factor-alpha and interleukin-1beta , or three cytokines , and the increase was further enhanced under hypoxia . Positive_regulation EDN1 TNF 16740997 1566578 Treatment with cerivastatin but not pitavastatin , pravastatin , or atorvastatin decreased basal and *stimulated* [ET-1] release from PAECs in a dose dependent manner ( 1-10 microM ) . Positive_regulation EDN1 TNF 16741035 1566600 ET-1 release from cultured endothelial cells was dose-dependently reduced by Ang-1 , which also prevented *induction* of [ET-1] release by ( P < 0.05 ) . Positive_regulation EDN1 TNF 16866310 1592790 Since *induces* endothelial cells to secrete [ET-1] , we hypothesise that ET-1 mediates the sensitising effects of TNF-alpha on the porcine CL during the mid-luteal phase ( days 7-13 ) . Positive_regulation EDN1 TNF 17023264 1630450 Evidence that N-acetylcysteine inhibits *induced* cerebrovascular [endothelin-1] upregulation via inhibition of mitogen- and stress activated protein kinase . Positive_regulation EDN1 TNF 17023264 1630451 We therefore examined the effect of NAC on *induced* [ET-1] production in cerebrovascular endothelial cells . Positive_regulation EDN1 TNF 17023264 1630453 NAC dose dependently inhibited *induced* preproET-1 mRNA upregulation and [ET-1] protein secretion , while upregulation of inducible nitric oxide synthase (iNOS) was unaffected . Positive_regulation EDN1 TNF 17023264 1630460 Supporting this notion , cotreatment with NAC inhibited the TNF-alpha induced rise in MSK1 and MSK2 kinase activity , while siRNA knock-down experiments showed that MSK2 is the predominant isoform involved in *induced* [ET-1] upregulation . Positive_regulation EDN1 TNF 17116693 1686259 Here we show that p8 , a small stress-inducible basic helix-loop-helix protein , is required for [endothelin-] and alpha-adrenergic agonist induced cardiomyocyte hypertrophy and for stimulated *induction* , in cardiac fibroblasts , of matrix metalloproteases ( MMPs ) 9 and 13-MMPs linked to general inflammation and to adverse ventricular remodeling in heart failure . Positive_regulation EDN1 TNF 1725904 176844 Human ( 30 ng/kg/min x 30 min ) , a putative mediator of endotoxin shock , *enhanced* plasma [ET-1] ( 18.3 +/- 1.0 vs. 2.7 +/- 0.4 pg/ml in the vehicle group ; p less than 0.05 ) by sevenfold and ET-3 levels by twofold ( 45.7 +/- 2.0 vs. 27.1 +/- 4.0 pg/ml in the vehicle group ; p less than 0.05 ) without affecting blood pressure . Positive_regulation EDN1 TNF 17640471 1771106 The *induction* of [ET-1] release by from cultured BMVEC was dose-dependently reduced by Tan IIA , but large ET-1 levels progressively increased in response to Tan IIA ; Positive_regulation EDN1 TNF 18475471 209535 ( 10 and 100 ng ml(-1) ) *increased* in a time dependent manner the [preproendothelin-1] mRNA levels in respect to unstimulated endothelial cells . Positive_regulation EDN1 TNF 18670098 1943250 Though *augmented* the levels of [endothelin-1 (ET-1)] and attenuated those of embryonic form of myosin heavy chain ( SMemb ) in HUVECs , the inhibition of KLF5 did not affect the levels of these cytokines in the cells . Positive_regulation EDN1 TNF 19745821 2140046 We examined the effect of 17-hydroxyprogesterone caproate ( 17-OHP ) on *stimulated* [endothelin (ET)] production and hypertension during pregnancy . Positive_regulation EDN1 TNF 19745821 2140049 Progesterone abolished *stimulated* [ET-1] from endothelial cells . Positive_regulation EDN1 TNF 19745821 2140050 Progesterone directly abolished *stimulated* [ET-1] and attenuated TNF-alpha induced hypertension , possibly via suppression of the renal ET-1 system . Positive_regulation EDN1 TNF 19850966 2170296 [ET-1] and granulocyte-macrophage colony stimulating factor ( GM-CSF ) expression in *response* to and ET-1 stimulation was investigated , and the impact of mitogen activated protein kinase (MAPK) pathways in this context was studied . Positive_regulation EDN1 TNF 19850966 2170303 [ET-1] expression was *induced* by and by ET-1 itself . Positive_regulation EDN1 TNF 19850966 2170309 Since bosentan impairs ET-1 autoregulation and *induced* [ET-1] release , as well as TNFalpha- and ET-1 induced GM-CSF release , the present data suggest therapeutic utility for bosentan in treating particularly the early stages of chronic inflammatory airway diseases . Positive_regulation EDN1 TNF 20138622 2280963 Mycophenolic acid attenuates *induced* [endothelin-1] production in human aortic endothelial cells . Positive_regulation EDN1 TNF 20138622 2280964 This study was conducted to evaluate the effect of mycophenolic acid ( MPA ) , an immunosuppressant for the transplant recipients , on *induced* [ET-1] production in aortic endothelial cells . Positive_regulation EDN1 TNF 20138622 2280967 In cultured human aortic endothelial cells , *increased* [ET-1] through AP-1 and NF-kappaB , whereas MPA attenuated it by reducing both AP-1 and NF-kappaB DNA binding activities . Positive_regulation EDN1 TNF 20138622 2280968 *increased* [ET-1] via c-Jun NH2-terminal kinase (JNK) and p38 mitogen activated protein kinase (MAPK) , but not extracellular signal regulated kinase . Positive_regulation EDN1 TNF 20138622 2280976 MPA attenuated *induced* [ET-1] production through inhibitions of ROS dependent JNK and ROS independent p38 MAPK that regulated NF-kappaB as well as AP-1 . Positive_regulation EDN1 TNF 20512083 2270530 [ET-1] secretion of EGCs could be *stimulated* by IL-1 beta and in a time and dose dependent manner , whereas IL-4 and interferon-gamma showed no effect on ET-1 production . Positive_regulation EDN1 TNF 21334436 2415222 Darbepoetin alfa suppresses *induced* [endothelin-1] production through antioxidant action in human aortic endothelial cells : role of sialic acid residues . Positive_regulation EDN1 TNF 21334436 2415223 Here , we tested whether darbepoetin alfa , a hypersialylated analogue of r-HuEPO , regulates *induced* [ET-1] production in human aortic endothelial cells , and sought to identify the signal pathways involved . Positive_regulation EDN1 TNF 21334436 2415224 Darbepoetin alfa attenuated *induced* [ET-1] production . Positive_regulation EDN1 TNF 21334436 2415227 Desialylation completely abolished darbepoetin alfa 's inhibitory effects on *induced* ROS accumulation , MSK1 activation , and [ET-1] gene expression , without affecting its stimulation of STAT5 activity . Positive_regulation EDN1 TNF 21334436 2415228 These data demonstrate that darbepoetin alfa suppresses *induced* [ET-1] production through its antioxidant action and suggest that the sialic acid residues of darbepoetin alfa are essential for its antioxidant effect , possibly by scavenging ROS . Positive_regulation EDN1 TNF 22207076 2549742 Activation of nuclear factor-?B pathway is responsible for *induced* up-regulation of [endothelin] B2 receptor expression in vascular smooth muscle cells in vitro . Positive_regulation EDN1 TNF 22249931 2569495 Bosentan , an endothelin receptor antagonist , ameliorates collagen induced arthritis : the *role* of in the induction of [endothelin] system genes . Positive_regulation EDN1 TNF 22321643 2571717 Activation of spleen tyrosine kinase is required for *induced* [endothelin-1] upregulation in human aortic endothelial cells . Positive_regulation EDN1 TNF 22321643 2571719 We tested whether spleen tyrosine kinase (Syk) mediates *induced* [ET-1] upregulation in human aortic endothelial cells ( HAECs ) and sought to identify the signal pathways involved . Positive_regulation EDN1 TNF 22956308 2726595 As also increases ADM levels in the epididymal fat and the soleus muscle and [EDN-1] also *increases* ADM levels in the epididymal fat , they may form a feedback loop with ADM in these tissues . Positive_regulation EDN1 TNF 24040253 2842580 Following SE , the release of *stimulated* [endothelin-1 (ET-1)] release and expression in neurons and endothelial cells . Positive_regulation EDN1 TNF 24040253 2842581 In addition , *induced* [ET-1] increased BBB permeability via ETB receptor mediated endothelial nitric oxide synthase (eNOS) activation in endothelial cells . Positive_regulation EDN1 TNF 7593352 330435 *enhanced* the release of [ET-1] in BCEC , and this enhancement was not modified by the simultaneous addition of interferon-gamma (IFN-gamma) . Positive_regulation EDN1 TNF 7938900 276228 Results suggest that is *involved* in the production of [ET-1] and TM . Positive_regulation EDN1 TNF 8163562 254536 Among the various cytokines , , interleukin-1 alpha , and transforming growth factor-beta *stimulated* [ET-1] secretion in a dose dependent manner . Positive_regulation EDN1 TNF 8425178 210941 Among the agents tested , estrogen , tamoxifen , , gamma-interferon , interleukin (IL) 1 , and transforming growth factor beta *had* no effect on [ir-ET-1] secretion by these breast cancer cells . Positive_regulation EDN1 TNF 8587467 341729 and IL-1 beta *caused* concentration dependent increases in [ET-1] release . Positive_regulation EDN1 TNF 8719812 343909 4. These data suggest that may *induce* the release of [endothelin-1 (ET-1)] and that this mediates at least part of the coronary vasoconstriction . Positive_regulation EDN1 TNF 8747795 344097 is *involved* in the production of [endothelin-1] and thrombomodulin , which play a role in the pathogenesis of DIC and whose blood levels reflect its severity . Positive_regulation EDN1 TNF 8762499 344185 We concluded that the release of [ET-1] *induced* by might play a certain role in development of airway hyperresponsiveness and airway remodeling . Positive_regulation EDN1 TNF 8982535 403871 may be *involved* in the production of [ET-1] and TM . Positive_regulation EDN1 TNF 9179432 434366 *stimulates* [ET-1] secretion from cultured BASMCsw ; Positive_regulation EDN1 TNF 9466472 485585 Role of lipid derived mediators in *induced* [endothelin-1] release in vivo . Positive_regulation EDN1 TNF 9466472 485586 We hypothesized that [endothelin (ET)] may be released in *response* to and that platelet activating factor (PAF) and cyclooxygenase products modulate TNF induced ET-1 release in vivo . Positive_regulation EDN1 TNF 9466472 485592 On the other hand , PAF neither significantly influences *induced* biosynthesis of [ET-1] nor its associated cardiovascular responses . Positive_regulation EDN1 TNF 9533826 511048 Cycloheximide ( 9 micron ) , a protein synthesis inhibitor , decreased TNF-alpha stimulated levels for ir-ET-1 and ir-Big ET-1 , suggesting that may be directly *regulating* [ET-1] expression at the ET-1 gene . Positive_regulation EDN1 TNF 9533826 511050 Our data indicates that *regulates* [ET-1] levels in HNPE cells possibly by activating PKC either to stimulate protein synthesis and/or to enhance ET-1 secretion . Positive_regulation EDN1 TNF 9687319 522189 Also , and IL-1beta *induced* further release of [ET-1] stimulated by LH ( p < 0.05 ) . Positive_regulation EDN1 TNF 9696707 524450 Although , LPS , and PAF *had* no significant effect on [ET-1] synthesis , TGF-beta increased ET-1 mRNA expression and irET-1 secretion . Positive_regulation EDN1 TNF 9811229 545658 Previously , we have shown that , a proinflammatory cytokine , *increases* the synthesis and release of [endothelin-1 (ET-1)] , a potent vasoactive peptide from human non pigmented ciliary epithelial ( HNPE ) cells , in a protein kinase C ( PKC ) -dependent manner . Positive_regulation EDN2 ACE 11747762 889391 Additional effects of [endothelin] receptor blockade and *inhibition* in rats with chronic heart failure . Positive_regulation EDN2 ACE 1316980 187842 We conducted a study to determine whether inhibitors ( ACEIs ) *inhibit* [endothelin] secretion from cultured human endothelial cells . Positive_regulation EDN2 ACE 1316980 187845 Although angiotensin II and *had* no significant effect on [endothelin] release , concentration dependent suppression occurred with bradykinin and sodium nitroprusside . Positive_regulation EDN2 ADCY1 10750028 681342 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone , indicating that and TNFalpha *induce* [ET-2] synthesis by separate signalling pathways . Positive_regulation EDN2 ADCY10 10750028 681341 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone , indicating that and TNFalpha *induce* [ET-2] synthesis by separate signalling pathways . Positive_regulation EDN2 ADCY2 10750028 681343 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone , indicating that and TNFalpha *induce* [ET-2] synthesis by separate signalling pathways . Positive_regulation EDN2 ADCY3 10750028 681344 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone , indicating that and TNFalpha *induce* [ET-2] synthesis by separate signalling pathways . Positive_regulation EDN2 ADCY4 10750028 681345 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone , indicating that and TNFalpha *induce* [ET-2] synthesis by separate signalling pathways . Positive_regulation EDN2 ADCY5 10750028 681346 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone , indicating that and TNFalpha *induce* [ET-2] synthesis by separate signalling pathways . Positive_regulation EDN2 ADCY6 10750028 681347 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone , indicating that and TNFalpha *induce* [ET-2] synthesis by separate signalling pathways . Positive_regulation EDN2 ADCY7 10750028 681348 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone , indicating that and TNFalpha *induce* [ET-2] synthesis by separate signalling pathways . Positive_regulation EDN2 ADCY8 10750028 681349 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone , indicating that and TNFalpha *induce* [ET-2] synthesis by separate signalling pathways . Positive_regulation EDN2 ADCY9 10750028 681350 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone , indicating that and TNFalpha *induce* [ET-2] synthesis by separate signalling pathways . Positive_regulation EDN2 ADRBK1 19748906 2186586 [Endothelin] signalling in arterial smooth muscle is tightly *regulated* by . Positive_regulation EDN2 AGTR2 11742865 887452 In contrast , [endothelin] *induced* a biphasic response , with activation and 10 minutes . Positive_regulation EDN2 AKT1 15860794 1425736 Both MBP1 and [EDN] *induced* phosphorylation of , but with divergent time courses and intensities , and survival was independent of Akt . Positive_regulation EDN2 AKT2 15860794 1425737 Both MBP1 and [EDN] *induced* phosphorylation of , but with divergent time courses and intensities , and survival was independent of Akt . Positive_regulation EDN2 AKT3 15860794 1425738 Both MBP1 and [EDN] *induced* phosphorylation of , but with divergent time courses and intensities , and survival was independent of Akt . Positive_regulation EDN2 ANG 11230326 789267 We tested the hypothesis that *induced* stimulations of [endothelin (ET)] and isoprostanes are implicated in the slow pressor responses to Ang II . Positive_regulation EDN2 ANGPT2 17166491 1679126 These findings demonstrate that changes in dietary fat intake modulate vascular reactivity in *response* to and ROS , as well as expression of vascular angiotensin and [endothelin] receptors . Positive_regulation EDN2 ANGPT2 9337215 458233 ACEI and AT1 Ang II blockade reduced LVEDD ( 4.68+/-0.07 cm ) and increased LVFS ( 25.2+/-0.9 % ) from pacing only ( P < .05 ) . Plasma norepinephrine and endothelin increased by more than fivefold with chronic pacing and remained elevated with AT1 Ang II blockade. Plasma norepinephrine was reduced from pacing-only values by more than twofold in the ACEI group and the combination group. ACEI and AT1 receptor blockade *reduced* plasma [endothelin] levels by > 50 % from rapid pacing values . Positive_regulation EDN2 APOB 1315634 185474 The *stimulated* release of [endothelin] was mimicked by acetylated low density lipoprotein and abolished by downregulation of protein kinase C by phorbol ester . Positive_regulation EDN2 APOB 24315856 2904898 Low density *induces* upregulation of vasoconstrictive [endothelin] type B receptor expression . Positive_regulation EDN2 APOB 8929252 386381 Acetyl slightly *increased* basal [endothelin] release by endothelial cells , but native LDL or mildly oxidized LDL had no significant effect . Positive_regulation EDN2 AVP 16011011 1431544 To study whether can *stimulate* [endothelin] production and/or release in vivo , in the human forearm vasculature . Positive_regulation EDN2 AVP 2010532 154953 *stimulates* human mesangial cell production of [endothelin] . Positive_regulation EDN2 AVP 8386472 217800 Natriuretic peptides inhibit mesangial cell production of [endothelin] *induced* by . Positive_regulation EDN2 BDNF 15898104 1411762 [Endothelin] *increases* expression of exon III- and exon IV-containing transcripts in cultured astrocytes and rat brain . Positive_regulation EDN2 C3 21208279 2374390 PI3-kinases play an important role in the *induced* release of ECP , EPO and [EPX/EDN] , whereas protein kinase C seems to have inhibitory effects on C3b induced degranulation . Positive_regulation EDN2 CA1 2499331 111906 Both in the presence and absence of extracellular Ca , [endothelin] *induced* rapid and dose dependent increases in [ and in contraction . Positive_regulation EDN2 CA1 2686633 122626 [Endothelin] ( 10 ( -10 ) -10 ( -6 ) M ) *induced* a dose dependent reversible membrane voltage depolarization and a dose dependent rise in [ . Positive_regulation EDN2 CA2 10101026 601967 Specific galpha11beta3gamma5 protein involvement in [endothelin] receptor *induced* phosphatidylinositol hydrolysis and release in rat portal vein myocytes . Positive_regulation EDN2 CA2 1316352 185670 When calcium-free buffer was used , 10 nM [endothelin] *induced* a transient rise in <[Ca2+> ] i of lesser amplitude , whereas 0.1 nM endothelin did not produce a significant rise . Positive_regulation EDN2 CA2 2189443 133686 [Endothelin] ( 10 ( -9 ) mol/L , 10 ( -8 ) mol/L , and 10 ( -7 ) mol/L ) did not *induce* any change in [Ca2+ ] i in the platelets of rats while thrombin ( 2 U/mL ) dramatically increased <[Ca2+> ] i as measured by these methods . Positive_regulation EDN2 CA2 2655594 111080 [Endothelin] *induced* prompt and sustained increase in intracellular in fura-2 loaded cells , and nicardipine inhibited this increase in intracellular Ca2+ . Positive_regulation EDN2 CA2 2674497 117782 In Ca2+-free solution , [endothelin] *induced* a transient increase in <[Ca2+> ] i and a sustained contraction . Positive_regulation EDN2 CA2 2684313 121115 In guinea-pig vas deferens , taenia caeci and ileal longitudinal muscle , [endothelin] *induced* small increases in <[Ca2+> ] cyt and tension . Positive_regulation EDN2 CA2 8845071 337800 Bradykinin and [endothelin] *induced* a lesser increase in <[Ca2+> ] i in both the peak increase and the total amount of calcium increase during a defined period of time in tail artery EC from SHR , compared with the respective EC from WKY rats . Positive_regulation EDN2 CALM3 1326288 195647 The corresponding loss of cytosolic PKC , but not of CaM-PK , suggests a translocation of PKC and an *activation* of by [endothelin] . Positive_regulation EDN2 CAV1 20026011 2200267 The *role* of beta ( 1 ) interaction in [endothelin] signaling through Galpha subunits . Positive_regulation EDN2 CCL11 9758899 536332 significantly *induced* [EDN] release in a dose dependent manner . Positive_regulation EDN2 CCL11 9758899 536335 *induced* [EDN] release was blocked by cytochalasin B in a dose dependent manner . Positive_regulation EDN2 CD28 15347370 1292245 Activation by sIgA and ligation *resulted* in the release of ECP and [EDN] , which was inhibited by IPD-1151T . Positive_regulation EDN2 CDC73 2051719 161804 In addition , [endothelin] *induced* a significant increase in the production of by isolated glomeruli ( Basal , 81 +/- 10 pg/mg protein ; endothelin , 10 ( -7 ) M , 140 +/- 18 pg/mg protein ) . Positive_regulation EDN2 CDC73 2689821 123944 Thus , [endothelin] is a highly toxic peptide with cardiotoxic effects , and may be *involved* in the pathogenesis of the sudden death . Positive_regulation EDN2 CGA 18516093 1918465 Taken together , we believe that hypoxia , but not the PR or COX-2 , regulate *induced* [EDN2] expression in the periovulatory follicle . Positive_regulation EDN2 CGB8 18516093 1918464 Taken together , we believe that hypoxia , but not the PR or COX-2 , regulate *induced* [EDN2] expression in the periovulatory follicle . Positive_regulation EDN2 CSF2 20523069 2271290 significantly *enhanced* [EDN] release by CD but not by BB . Positive_regulation EDN2 CSF2 2104901 126865 and rIL-3 also *enhanced* Ig-induced [EDN] release but less potently than rIL-5 . Positive_regulation EDN2 CTR9 2051719 161805 In addition , [endothelin] *induced* a significant increase in the production of by isolated glomeruli ( Basal , 81 +/- 10 pg/mg protein ; endothelin , 10 ( -7 ) M , 140 +/- 18 pg/mg protein ) . Positive_regulation EDN2 CTR9 2689821 123945 Thus , [endothelin] is a highly toxic peptide with cardiotoxic effects , and may be *involved* in the pathogenesis of the sudden death . Positive_regulation EDN2 CTSD 2194455 136302 From these results , we concluded that the major [endothelin] converting activities in the soluble fraction of endothelial cells are *due* to . Positive_regulation EDN2 CXCL10 22004287 2507805 , but not Mig or I-TAC , *increased* the release of [EDN] . Positive_regulation EDN2 CXCL11 22004287 2507806 IP-10 , but not Mig or , *increased* the release of [EDN] . Positive_regulation EDN2 CXCL9 22004287 2507807 IP-10 , but not or I-TAC , *increased* the release of [EDN] . Positive_regulation EDN2 ECE1 9207226 440742 Therefore , VEGF increased ECE-1 expression in BAEC , which suggests that induction by VEGF may be *involved* in [endothelin-system] upregulation under pathological conditions such as neointimal formation and atherosclerosis . Positive_regulation EDN2 EDAR 16985888 1496968 The following 4 theories have been used to explain how these disorders interrelate : 1 ) decreased or altered nitric oxide synthase/nitric oxide levels in the prostate and penile smooth muscle ; 2 ) autonomic hyperactivity effects on LUTS , prostate growth , and ) *increased* Rho-kinase [activation/endothelin] activity ; and 4 ) prostate and penile atherosclerosis . Positive_regulation EDN2 EDN1 10455291 638659 Big ( 3 x 10 ( -8 ) M - 10 ( -6 ) M ) also *caused* this increase , but not big [ET-2] at concentrations up to 10 ( -6 ) M . Positive_regulation EDN2 EDN1 10673066 667336 This result , together with the findings that plasma and hepatic [endothelin] levels were elevated in cirrhotic rats and that exogenous *increased* portal pressure , provides further support for a role of endothelin in portal hypertension and suggests a potential use of mixed endothelin antagonist in the pharmacological treatment of portal hypertension . Positive_regulation EDN2 EDN1 11214636 763899 [Endothelin] is a family of potent vasoconstrictive peptides , and produced in the endothelium *induces* a tonic contraction via specific receptor ET ( A ) . Positive_regulation EDN2 EDN1 11414314 828931 However , ET-3 induced damaging effects are less pronounced , while most severely alters microcirculation and [ET-2] preferentially *induces* leukocyte dependent inflammation . Positive_regulation EDN2 EDN1 12372435 996417 We observed through real-time PCR analysis that ET-1 and [VIC/ET-2] gene expression gradually *increase* after parturition and that gene expression is significantly higher than that of VIC/ET-2 . Positive_regulation EDN2 EDN1 15998353 1430388 Unexpected , *induced* an [endothelin] ( A ) mediated vasodilation . Positive_regulation EDN2 EDN1 17445794 1742891 *Stimulation* of [endothelin] ETA receptor with is generally believed to induce an increase in intracellular Ca2+ concentration ([Ca2+]i) via Gq/11 protein . Positive_regulation EDN2 EDN1 17445794 1742901 These results suggest that *stimulation* of [endothelin] ETA receptor with activates the forward mode NCX through Gq/11 dependent and -independent mechanisms : the NCX exports Ca2+ out of the cell depending on Na+ gradient across the cell membrane , resulting in the decrease in [ Ca2+ ] i . Positive_regulation EDN2 EDN1 17612974 1768735 The physiological properties of endothelin-1 in ocular choroidal melanocytes are not well-known , although *increases* the intracellular calcium concentration through [endothelin-B] receptors in skin melanocytes . Positive_regulation EDN2 EDN1 21057729 2344650 Recent studies have demonstrated that [endothelin] receptor up-regulation mediates vascular and airway hyper-reactivity in *response* to ( ET-1 , endothelin receptor agonist ) in cardiovascular and airway diseases . Positive_regulation EDN2 EDN1 22492044 2583539 One involves SFO dependent activation of the paraventricular hypothalamic nucleus , elevations in plasma vasopressin , upregulation of in cerebral resistance arterioles and *activation* of [endothelin] type A receptors . Positive_regulation EDN2 EDN1 23256109 2709079 seems to enhance the pro-fibrotic protein synthesis by skin fibroblasts and its effects are *mediated* by [endothelin-A] and B ( ETA and ETB ) receptors . Positive_regulation EDN2 EDN1 23662699 2800769 [Endothelin] receptors in augmented vasoconstrictor *responses* to in chronic intermittent hypoxia . Positive_regulation EDN2 EDN1 25088996 2954070 The *induced* vasoconstriction , ET-1 binding , and [endothelin] receptor expression were explored in the isolated endothelium denuded aortae and A-10 VSMCs . Positive_regulation EDN2 EDN1 7550073 327173 Demonstration of [endothelin (ET)] receptors on cultured rabbit chondrocytes and *stimulation* of DNA synthesis and calcium influx by via its receptors . Positive_regulation EDN2 EDN1 7650059 319311 *induces* gene expression through stimulation of [endothelin] type A receptors in normal rat kidney cells . Positive_regulation EDN2 EDN1 8039848 266643 Phosphoramidon ( 10 ( -4 ) mol/L ) , a metalloproteinase inhibitor , significantly suppressed the big induced pressor action and the *accumulation* of immunoreactive [endothelin] in renal tissues . Positive_regulation EDN2 EDN1 8441230 213376 Here we explored whether the increased urinary [endothelin] in this model were *due* to induction of renal gene and whether changes in endothelin synthetic pathway correlated with the development of glomerulosclerosis . Positive_regulation EDN2 EDN1 8581288 341167 Roles of [endothelin] receptors in the regional and systemic vascular *responses* to in the anaesthetized ganglion blocked rat : use of selective antagonists . Positive_regulation EDN2 EDN1 8587339 341620 The present study aimed to characterize [endothelin (ET)] receptors *mediating* the effects of in the rat fundic strip . Positive_regulation EDN2 EDN1 8891597 391966 It is concluded that at low concentrations *activates* prejunctional [endothelin] ETA receptors and inhibits adrenergic nerve mediated contractions by an inhibition of amine release , whereas the peptide at high concentrations potentiates the neurally induced contractions by a postjunctional enhancement , via endothelin ETA receptors , of the action of norepinephrine . Positive_regulation EDN2 EDN1 9105880 424353 The present results suggest that the pulmonary vasodilator effect of exogenously administered during acute hypoxia is *mediated* by [endothelin] ETB receptors in the pig . Positive_regulation EDN2 EDN1 9831916 551591 2 . ( 100 nM ) produced distinct NC in the presence of BQ788 ( 300 nM ) , and positive chronotropic response ( PC ) in the presence of BQ123 ( 1 microM ) in both species , showing that ETAR and ET ( B ) [endothelin] receptor ( ET ( B ) R ) *mediate* NC and PC , respectively . Positive_regulation EDN2 EDN1 9832389 551725 These results suggest that in the rabbit kidney in vivo endothelin ET ( A ) receptors mediate endothelin-1 evoked vasoconstriction and tubular Na+ reabsorption , that the concomitant *stimulation* of [endothelin] ET ( B ) receptors by counteracts both the ET ( A ) receptor mediated vascular and tubular actions , and that the tubular action , but not the vascular action , of endothelin-1 is also susceptible to changes in renal NO level . Positive_regulation EDN2 EDN3 9595408 505945 In contrast , ET-1 and [ET-2] significantly *induced* SMC migration in the presence of low concentrations of PDGF-BB ( 0.5 ng/mL ) or Ang II ( 10 ( -9 ) mol/L ) , although was less active ( ET-1 = ET-2 > ET-3 ) . Positive_regulation EDN2 EDNRA 18516103 1918507 On the other hand , decreased left ventricular end-diastolic pressure was observed in cardiomyopathic hamsters after selective ETA- or combined nonselective ETA/ETB-receptor antagonism , while only selective blockade *reduced* left ventricular [endothelin] levels . Positive_regulation EDN2 EDNRA 24064210 2863147 , a G protein coupled receptor , *mediates* [endothelin] signaling , which is regulated by GRK2 . Positive_regulation EDN2 EDNRA 8831102 385707 These investigations indicate that endothelin receptors mediate vasoconstriction and [endothelin] ETB receptors *mediate* vasodilatation in feline cerebral resistance arterioles in vivo . Positive_regulation EDN2 EDNRA 9325182 456737 Angiotensin II increases vascular and renal endothelin-1 and functional endothelin converting enzyme activity in vivo : *role* of receptors for [endothelin] regulation . Positive_regulation EDN2 EDNRB 18090673 1847357 Next , this review will outline the progression of data providing support for our hypothesis that an intra-renal mechanism of [endothelin] *activation* of receptors stimulates NOS1 activity and nitric oxide production to promote sodium excretion . Positive_regulation EDN2 EDNRB 8831102 385708 These investigations indicate that [endothelin] ETA receptors mediate vasoconstriction and endothelin receptors *mediate* vasodilatation in feline cerebral resistance arterioles in vivo . Positive_regulation EDN2 EDNRB 8937719 398389 These findings suggest that functional receptors *contribute* significantly to the [endothelin] contractile response in cultured arteries . Positive_regulation EDN2 EGR1 8060311 268217 Three groups of responses could be distinguished : 1. AII , [endothelin] , phenylephrine , and PMA *induced* mRNA accumulation , but the message remained untranslated . Positive_regulation EDN2 ELL 19393623 2075074 Thus , [endothelin] *induces* cortical neurite through the endothelin A receptor by a mechanism dependent on JNK . Positive_regulation EDN2 EPHB2 12475899 1037726 [Endothelin] *induced* a rapid phosphorylation of the mitogen activated protein kinase <(MAPK)/ERK> and increased collagen I gene activity in freshly isolated aortas . Positive_regulation EDN2 EPHB2 19575782 2111465 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Positive_regulation EDN2 EPO 7722326 301728 MBP ( 10 micrograms/ml ) and ( 0.1 micrograms/ml ) *induced* [EDN] release comparable with one of the strongest agonists for eosinophils , secretory IgA . Positive_regulation EDN2 EPO 8152333 253033 Direct evidence for *induced* release of [endothelin] from peripheral vascular tissue . Positive_regulation EDN2 EPO 8471228 216185 Intravenous ( rHuEPO ) administration *increases* plasma [endothelin] and blood pressure in hemodialysis patients . Positive_regulation EDN2 EPO 8840276 386777 *induces* [endothelin] expression in endothelial cells ( EC ) and has angiogenic effects . Positive_regulation EDN2 EPX 15322761 1303802 promotes angiogenesis and *stimulates* the production of [endothelin] and other vasoactive mediators . Positive_regulation EDN2 EPX 7722326 301734 Pretreatment of cells with dibutyryl cAMP or cytochalasin B completely abolished the [EDN] release *induced* by MBP and , suggesting that the effects of MBP and EPO are not due to cytotoxic lysis of the cells . Positive_regulation EDN2 ETS1 23336509 2733758 The biological effects of are *mediated* by two receptors , namely , [endothelin] type A receptor ( ET ( A ) R ) and endothelin type B receptor ( ET ( B ) R ) . Positive_regulation EDN2 ETS2 23336509 2733759 The biological effects of are *mediated* by two receptors , namely , endothelin type A receptor ( ET ( A ) R ) and [endothelin] type B receptor ( ET ( B ) R ) . Positive_regulation EDN2 FGF2 12147302 970014 Reduction of *induced* smooth muscle cell proliferation and [endothelin] receptor mRNA expression by mevastatin and atorvastatin . Positive_regulation EDN2 FN1 19505428 2092074 *stimulated* transcription of preproendothelin-1 messenger RNA and expression of [endothelin] through an integrin dependent pathway in activated hepatic stellate cells . Positive_regulation EDN2 GATA2 19279013 2063580 silencing of *resulted* in diminished expression of [EDN] , and also diminished expression of GATA-1 in both butyric acid induced HL-60 clone 15 cells and in differentiating human eosinophils derived from CD34 ( + ) hematopoietic progenitors . Positive_regulation EDN2 GATA2 19279013 2063588 Likewise , overexpression of in uninduced HL-60 clone 15 cells *resulted* in augmented transcription of both [EDN] and GATA-1 . Positive_regulation EDN2 GNA12 17878759 1797091 Selective *activation* of human atrial and Galpha13 by Galphaq coupled angiotensin and [endothelin] receptors . Positive_regulation EDN2 GNA13 17878759 1797092 Selective *activation* of human atrial Galpha12 and by Galphaq coupled angiotensin and [endothelin] receptors . Positive_regulation EDN2 GPI 1292682 207793 [Endothelin] *induced* biphasic changes in : initial decrease followed by a subsequent increase above the basal level due to activation of the Na+/H+ exchange . Positive_regulation EDN2 HNRNPF 15528350 1332530 Additionally , [EDN] and hPR also *induced* phenotypic and functional maturation . Positive_regulation EDN2 HNRNPH1 15528350 1332531 Additionally , [EDN] and hPR also *induced* phenotypic and functional maturation . Positive_regulation EDN2 HSPG2 8477817 218622 The *activation* of or PLD by [endothelin] in the three cell lines was mediated by the high affinity binding site ( nM range ) and was not significantly affected by either extracellular or intracellular Ca2+ . Positive_regulation EDN2 ICAM1 9651192 515485 In the *presence* of GM-CSF , and VCAM-1 caused significant release of [EOS derived neurotoxin (EDN)] . Positive_regulation EDN2 IFNG 10764953 684166 ( 100 U/ml ) *increased* the [immunoreactive-endothelin] levels , but not immunoreactive-adrenomedullin levels , whereas interleukin-1 (IL-1)beta ( 10 ng/ml ) increased immunoreactive-adrenomedullin levels , but not immunoreactive-endothelin levels . Positive_regulation EDN2 IL10 16024732 1465932 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL11 16024732 1465933 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL13 16024732 1465934 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL15 16024732 1465935 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL16 16024732 1465936 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL18 16024732 1465937 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL19 16024732 1465938 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL1B 10395413 627456 Segments of human temporal artery were placed in organ culture for up to 4 days and examined for [endothelin] ET ( B ) receptor activity in the *presence* and absence of the pro-inflammatory cytokine by in vitro pharmacology and reverse transcriptase-polymerase chain reaction ( RT-PCR ) . Positive_regulation EDN2 IL1B 10764953 684167 Interferon-gamma ( 100 U/ml ) increased the immunoreactive-endothelin levels , but not immunoreactive-adrenomedullin levels , whereas ( 10 ng/ml ) *increased* immunoreactive-adrenomedullin levels , but not [immunoreactive-endothelin] levels . Positive_regulation EDN2 IL1B 1445301 205191 Intracellular signal transduction for *induced* [endothelin] production in human umbilical vein endothelial cells . Positive_regulation EDN2 IL1B 1445301 205194 The authors investigated the intracellular signal transduction for *induced* [endothelin (ET)] production by endothelial cells from cultured human umbilical vein ( HUVEC ) . Positive_regulation EDN2 IL1B 18524861 1939822 , but not interleukin-6 , *enhances* renal and systemic [endothelin] production in vivo . Positive_regulation EDN2 IL1B 7729539 302163 We report that is a potent *inducer* of [endothelin] receptor expression in cultured human vascular smooth muscle cells . Positive_regulation EDN2 IL2 16024732 1465939 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL20 16024732 1465940 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL21 16024732 1465941 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL22 16024732 1465924 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL24 16024732 1465922 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL25 16024732 1465923 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL26 16024732 1465928 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL27 16024732 1465929 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL3 16024732 1465942 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL31 16024732 1465930 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL32 16024732 1465927 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL33 16024732 1465926 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL34 16024732 1465931 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL37 16024732 1465925 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL4 16024732 1465943 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL5 11883736 919696 Theophylline inhibited *induced* release of [EDN] in a concentration dependent manner . Positive_regulation EDN2 IL5 12373000 996511 LTE ( 4 ) also induced significant eosinophil migration at 10 ( -6 ) M. LTD ( 4 ) enhanced [EDN] release *induced* by via CysLT(1) . Positive_regulation EDN2 IL5 15818060 1432454 We investigated the effect of a PPARgamma agonist on human eosinophil functions such as *induced* CD69 surface expression and [EDN] release . Positive_regulation EDN2 IL5 15818060 1432459 *induced* eosinophil CD69 surface expression and [EDN] release were significantly inhibited by the synthetic PPARgamma agonist troglitazone , and these effects were reversed by a PPARgamma antagonist . Positive_regulation EDN2 IL5 16024732 1465944 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL5 18622140 1984410 Treatment with HGF suppressed *induced* upregulation of CD69 expression , ROS production and [EDN] release from human eosinophils . Positive_regulation EDN2 IL5 22595142 2632248 significantly *enhanced* SA-induced [EDN] release . Positive_regulation EDN2 IL6 16024732 1465945 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL6 18524861 1939823 Interleukin-1beta , but not , *enhances* renal and systemic [endothelin] production in vivo . Positive_regulation EDN2 IL7 16024732 1465946 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL8 16024732 1465947 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 IL9 16024732 1465948 Nociceptive effect of subcutaneously injected is *mediated* by [endothelin (ET)] acting on ETB receptors in rats . Positive_regulation EDN2 INS 10409220 629880 *induced* [endothelin] release and vasoreactivity in hypertriglyceridemic and hypertensive rats . Positive_regulation EDN2 INS 10409220 629883 [Endothelin] release *induced* with KCl plus 50 microU/ml resulted in increases in contractile responses : 41 +/- 5.9 and 57 +/- 6 % for control and 65.5 +/- 6 and 95 +/- 9 % for HTG aortas and femoral arteries , respectively . Positive_regulation EDN2 INS 10458717 639442 *stimulates* both [endothelin] and nitric oxide activity in the human forearm . Positive_regulation EDN2 INS 16427233 1534061 Effect of age on *induced* [endothelin] release and vasoreactivity in hypertriglyceridemic and hypertensive rats . Positive_regulation EDN2 INS 16427233 1534064 Increased [endothelin] release *induced* by remained constant in normal rats , while in HTG rats it was higher than in controls at all ages . Positive_regulation EDN2 INS 8028512 263600 *increases* the release of [endothelin] in endothelial cell cultures in vitro but not in vivo . Positive_regulation EDN2 INS 8412756 233688 at a concentration of 320 microU/mL *induced* a significant increase of immunoreactive [endothelin] levels in medium ( from 15.2 +/- 0.8 to 20.6 +/- 0.8 pg/200 microL , P < .01 ) and potentiated arginine vasopressin- and angiotensin II-induced immunoreactive endothelin release ( P < .0001 and P < .04 , respectively ) . Positive_regulation EDN2 INS 8412756 233692 at a concentration of 80 microU/mL did not induce a significant *increase* of spontaneous immunoreactive [endothelin] release , but significantly increased the effects of arginine vasopressin ( P < .05 ) . Positive_regulation EDN2 INS 9111160 425504 Since [endothelin] production is *stimulated* in vitro by , we performed this study to evaluate in vivo the relationships between endothelin and insulin plasma levels during a glucose load . Positive_regulation EDN2 LEO1 2051719 161808 In addition , [endothelin] *induced* a significant increase in the production of by isolated glomeruli ( Basal , 81 +/- 10 pg/mg protein ; endothelin , 10 ( -7 ) M , 140 +/- 18 pg/mg protein ) . Positive_regulation EDN2 LEO1 2689821 123948 Thus , [endothelin] is a highly toxic peptide with cardiotoxic effects , and may be *involved* in the pathogenesis of the sudden death . Positive_regulation EDN2 LPA 24315856 2904899 Low density *induces* upregulation of vasoconstrictive [endothelin] type B receptor expression . Positive_regulation EDN2 MAGEE1 1583632 187637 to the endothelial cells may then *stimulate* the synthesis of [endothelin] to initiate a vicious cycle . Positive_regulation EDN2 MAPK1 12475899 1037727 [Endothelin] *induced* a rapid phosphorylation of the and increased collagen I gene activity in freshly isolated aortas . Positive_regulation EDN2 MAPK1 12855582 1149849 [EDN] also *induced* the activation of p42/44 in DCs . Positive_regulation EDN2 MAPK1 18031734 1851969 Also , the increase in sarafotoxin 6c contraction , [endothelin] ET ( B ) receptor and mRNA levels and endothelin ET ( A ) and ET ( B ) immunofluorescence staining intensities were *inhibited* by inhibitors for extracellular signal related kinases 1 and 2 ( ERK1/2 ) , PD98059 ( 10 microM ) , C-jun terminal kinase ( JNK ) , SP600125 ( 10 microM ) , but not by p38 MAPK , SB203580 ( 10 microM ) . Positive_regulation EDN2 MAPK1 19575782 2111466 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Positive_regulation EDN2 MAPK1 21057729 2344624 Up-regulation of [endothelin] receptors *induced* by cigarette smoke -- involvement of in vascular and airway hyper-reactivity . Positive_regulation EDN2 MAPK10 12475899 1037728 [Endothelin] *induced* a rapid phosphorylation of the and increased collagen I gene activity in freshly isolated aortas . Positive_regulation EDN2 MAPK10 12855582 1149850 [EDN] also *induced* the activation of p42/44 in DCs . Positive_regulation EDN2 MAPK10 18031734 1851970 Also , the increase in sarafotoxin 6c contraction , [endothelin] ET ( B ) receptor and mRNA levels and endothelin ET ( A ) and ET ( B ) immunofluorescence staining intensities were *inhibited* by inhibitors for extracellular signal related kinases 1 and 2 ( ERK1/2 ) , PD98059 ( 10 microM ) , C-jun terminal kinase ( JNK ) , SP600125 ( 10 microM ) , but not by p38 MAPK , SB203580 ( 10 microM ) . Positive_regulation EDN2 MAPK10 19575782 2111467 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Positive_regulation EDN2 MAPK10 21057729 2344625 Up-regulation of [endothelin] receptors *induced* by cigarette smoke -- involvement of in vascular and airway hyper-reactivity . Positive_regulation EDN2 MAPK11 12475899 1037729 [Endothelin] *induced* a rapid phosphorylation of the and increased collagen I gene activity in freshly isolated aortas . Positive_regulation EDN2 MAPK11 12855582 1149851 [EDN] also *induced* the activation of p42/44 in DCs . Positive_regulation EDN2 MAPK11 18031734 1851971 Also , the increase in sarafotoxin 6c contraction , [endothelin] ET ( B ) receptor and mRNA levels and endothelin ET ( A ) and ET ( B ) immunofluorescence staining intensities were *inhibited* by inhibitors for extracellular signal related kinases 1 and 2 ( ERK1/2 ) , PD98059 ( 10 microM ) , C-jun terminal kinase ( JNK ) , SP600125 ( 10 microM ) , but not by p38 MAPK , SB203580 ( 10 microM ) . Positive_regulation EDN2 MAPK11 19575782 2111468 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Positive_regulation EDN2 MAPK11 21057729 2344626 Up-regulation of [endothelin] receptors *induced* by cigarette smoke -- involvement of in vascular and airway hyper-reactivity . Positive_regulation EDN2 MAPK12 12475899 1037730 [Endothelin] *induced* a rapid phosphorylation of the and increased collagen I gene activity in freshly isolated aortas . Positive_regulation EDN2 MAPK12 12855582 1149852 [EDN] also *induced* the activation of p42/44 in DCs . Positive_regulation EDN2 MAPK12 18031734 1851972 Also , the increase in sarafotoxin 6c contraction , [endothelin] ET ( B ) receptor and mRNA levels and endothelin ET ( A ) and ET ( B ) immunofluorescence staining intensities were *inhibited* by inhibitors for extracellular signal related kinases 1 and 2 ( ERK1/2 ) , PD98059 ( 10 microM ) , C-jun terminal kinase ( JNK ) , SP600125 ( 10 microM ) , but not by p38 MAPK , SB203580 ( 10 microM ) . Positive_regulation EDN2 MAPK12 19575782 2111469 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Positive_regulation EDN2 MAPK12 21057729 2344627 Up-regulation of [endothelin] receptors *induced* by cigarette smoke -- involvement of in vascular and airway hyper-reactivity . Positive_regulation EDN2 MAPK13 12475899 1037731 [Endothelin] *induced* a rapid phosphorylation of the and increased collagen I gene activity in freshly isolated aortas . Positive_regulation EDN2 MAPK13 12855582 1149853 [EDN] also *induced* the activation of p42/44 in DCs . Positive_regulation EDN2 MAPK13 18031734 1851973 Also , the increase in sarafotoxin 6c contraction , [endothelin] ET ( B ) receptor and mRNA levels and endothelin ET ( A ) and ET ( B ) immunofluorescence staining intensities were *inhibited* by inhibitors for extracellular signal related kinases 1 and 2 ( ERK1/2 ) , PD98059 ( 10 microM ) , C-jun terminal kinase ( JNK ) , SP600125 ( 10 microM ) , but not by p38 MAPK , SB203580 ( 10 microM ) . Positive_regulation EDN2 MAPK13 19575782 2111470 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Positive_regulation EDN2 MAPK13 21057729 2344628 Up-regulation of [endothelin] receptors *induced* by cigarette smoke -- involvement of in vascular and airway hyper-reactivity . Positive_regulation EDN2 MAPK14 12475899 1037732 [Endothelin] *induced* a rapid phosphorylation of the and increased collagen I gene activity in freshly isolated aortas . Positive_regulation EDN2 MAPK14 12855582 1149854 [EDN] also *induced* the activation of p42/44 in DCs . Positive_regulation EDN2 MAPK14 18031734 1851974 Also , the increase in sarafotoxin 6c contraction , [endothelin] ET ( B ) receptor and mRNA levels and endothelin ET ( A ) and ET ( B ) immunofluorescence staining intensities were *inhibited* by inhibitors for extracellular signal related kinases 1 and 2 ( ERK1/2 ) , PD98059 ( 10 microM ) , C-jun terminal kinase ( JNK ) , SP600125 ( 10 microM ) , but not by p38 MAPK , SB203580 ( 10 microM ) . Positive_regulation EDN2 MAPK14 19575782 2111471 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Positive_regulation EDN2 MAPK14 21057729 2344629 Up-regulation of [endothelin] receptors *induced* by cigarette smoke -- involvement of in vascular and airway hyper-reactivity . Positive_regulation EDN2 MAPK15 12475899 1037725 [Endothelin] *induced* a rapid phosphorylation of the and increased collagen I gene activity in freshly isolated aortas . Positive_regulation EDN2 MAPK15 12855582 1149848 [EDN] also *induced* the activation of p42/44 in DCs . Positive_regulation EDN2 MAPK15 18031734 1851968 Also , the increase in sarafotoxin 6c contraction , [endothelin] ET ( B ) receptor and mRNA levels and endothelin ET ( A ) and ET ( B ) immunofluorescence staining intensities were *inhibited* by inhibitors for extracellular signal related kinases 1 and 2 ( ERK1/2 ) , PD98059 ( 10 microM ) , C-jun terminal kinase ( JNK ) , SP600125 ( 10 microM ) , but not by p38 MAPK , SB203580 ( 10 microM ) . Positive_regulation EDN2 MAPK15 19575782 2111464 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Positive_regulation EDN2 MAPK15 21057729 2344623 Up-regulation of [endothelin] receptors *induced* by cigarette smoke -- involvement of in vascular and airway hyper-reactivity . Positive_regulation EDN2 MAPK3 12475899 1037733 [Endothelin] *induced* a rapid phosphorylation of the and increased collagen I gene activity in freshly isolated aortas . Positive_regulation EDN2 MAPK3 12855582 1149855 [EDN] also *induced* the activation of p42/44 in DCs . Positive_regulation EDN2 MAPK3 18031734 1851975 Also , the increase in sarafotoxin 6c contraction , [endothelin] ET ( B ) receptor and mRNA levels and endothelin ET ( A ) and ET ( B ) immunofluorescence staining intensities were *inhibited* by inhibitors for extracellular signal related kinases 1 and 2 ( ERK1/2 ) , PD98059 ( 10 microM ) , C-jun terminal kinase ( JNK ) , SP600125 ( 10 microM ) , but not by p38 MAPK , SB203580 ( 10 microM ) . Positive_regulation EDN2 MAPK3 19575782 2111472 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Positive_regulation EDN2 MAPK3 21057729 2344630 Up-regulation of [endothelin] receptors *induced* by cigarette smoke -- involvement of in vascular and airway hyper-reactivity . Positive_regulation EDN2 MAPK4 12475899 1037734 [Endothelin] *induced* a rapid phosphorylation of the and increased collagen I gene activity in freshly isolated aortas . Positive_regulation EDN2 MAPK4 12855582 1149856 [EDN] also *induced* the activation of p42/44 in DCs . Positive_regulation EDN2 MAPK4 18031734 1851976 Also , the increase in sarafotoxin 6c contraction , [endothelin] ET ( B ) receptor and mRNA levels and endothelin ET ( A ) and ET ( B ) immunofluorescence staining intensities were *inhibited* by inhibitors for extracellular signal related kinases 1 and 2 ( ERK1/2 ) , PD98059 ( 10 microM ) , C-jun terminal kinase ( JNK ) , SP600125 ( 10 microM ) , but not by p38 MAPK , SB203580 ( 10 microM ) . Positive_regulation EDN2 MAPK4 19575782 2111473 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Positive_regulation EDN2 MAPK4 21057729 2344631 Up-regulation of [endothelin] receptors *induced* by cigarette smoke -- involvement of in vascular and airway hyper-reactivity . Positive_regulation EDN2 MAPK6 12475899 1037735 [Endothelin] *induced* a rapid phosphorylation of the and increased collagen I gene activity in freshly isolated aortas . Positive_regulation EDN2 MAPK6 12855582 1149857 [EDN] also *induced* the activation of p42/44 in DCs . Positive_regulation EDN2 MAPK6 18031734 1851977 Also , the increase in sarafotoxin 6c contraction , [endothelin] ET ( B ) receptor and mRNA levels and endothelin ET ( A ) and ET ( B ) immunofluorescence staining intensities were *inhibited* by inhibitors for extracellular signal related kinases 1 and 2 ( ERK1/2 ) , PD98059 ( 10 microM ) , C-jun terminal kinase ( JNK ) , SP600125 ( 10 microM ) , but not by p38 MAPK , SB203580 ( 10 microM ) . Positive_regulation EDN2 MAPK6 19575782 2111474 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Positive_regulation EDN2 MAPK6 21057729 2344632 Up-regulation of [endothelin] receptors *induced* by cigarette smoke -- involvement of in vascular and airway hyper-reactivity . Positive_regulation EDN2 MAPK7 12475899 1037736 [Endothelin] *induced* a rapid phosphorylation of the and increased collagen I gene activity in freshly isolated aortas . Positive_regulation EDN2 MAPK7 12855582 1149858 [EDN] also *induced* the activation of p42/44 in DCs . Positive_regulation EDN2 MAPK7 18031734 1851978 Also , the increase in sarafotoxin 6c contraction , [endothelin] ET ( B ) receptor and mRNA levels and endothelin ET ( A ) and ET ( B ) immunofluorescence staining intensities were *inhibited* by inhibitors for extracellular signal related kinases 1 and 2 ( ERK1/2 ) , PD98059 ( 10 microM ) , C-jun terminal kinase ( JNK ) , SP600125 ( 10 microM ) , but not by p38 MAPK , SB203580 ( 10 microM ) . Positive_regulation EDN2 MAPK7 19575782 2111475 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Positive_regulation EDN2 MAPK7 21057729 2344633 Up-regulation of [endothelin] receptors *induced* by cigarette smoke -- involvement of in vascular and airway hyper-reactivity . Positive_regulation EDN2 MAPK8 12475899 1037737 [Endothelin] *induced* a rapid phosphorylation of the and increased collagen I gene activity in freshly isolated aortas . Positive_regulation EDN2 MAPK8 12855582 1149859 [EDN] also *induced* the activation of p42/44 in DCs . Positive_regulation EDN2 MAPK8 18031734 1851979 Also , the increase in sarafotoxin 6c contraction , [endothelin] ET ( B ) receptor and mRNA levels and endothelin ET ( A ) and ET ( B ) immunofluorescence staining intensities were *inhibited* by inhibitors for extracellular signal related kinases 1 and 2 ( ERK1/2 ) , PD98059 ( 10 microM ) , C-jun terminal kinase ( JNK ) , SP600125 ( 10 microM ) , but not by p38 MAPK , SB203580 ( 10 microM ) . Positive_regulation EDN2 MAPK8 19575782 2111476 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Positive_regulation EDN2 MAPK8 21057729 2344634 Up-regulation of [endothelin] receptors *induced* by cigarette smoke -- involvement of in vascular and airway hyper-reactivity . Positive_regulation EDN2 MAPK9 12475899 1037738 [Endothelin] *induced* a rapid phosphorylation of the and increased collagen I gene activity in freshly isolated aortas . Positive_regulation EDN2 MAPK9 12855582 1149860 [EDN] also *induced* the activation of p42/44 in DCs . Positive_regulation EDN2 MAPK9 18031734 1851980 Also , the increase in sarafotoxin 6c contraction , [endothelin] ET ( B ) receptor and mRNA levels and endothelin ET ( A ) and ET ( B ) immunofluorescence staining intensities were *inhibited* by inhibitors for extracellular signal related kinases 1 and 2 ( ERK1/2 ) , PD98059 ( 10 microM ) , C-jun terminal kinase ( JNK ) , SP600125 ( 10 microM ) , but not by p38 MAPK , SB203580 ( 10 microM ) . Positive_regulation EDN2 MAPK9 19575782 2111477 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Positive_regulation EDN2 MAPK9 21057729 2344635 Up-regulation of [endothelin] receptors *induced* by cigarette smoke -- involvement of in vascular and airway hyper-reactivity . Positive_regulation EDN2 MBP 2201205 140444 [Endothelin] ( 0.07-1.4 nmol/kg iv ) *induced* a long lasting increase in and a decrease in renal blood flow ( RBF ) . Positive_regulation EDN2 MBP 7722326 301729 ( 10 micrograms/ml ) and EPO ( 0.1 micrograms/ml ) *induced* [EDN] release comparable with one of the strongest agonists for eosinophils , secretory IgA . Positive_regulation EDN2 MBP 7722326 301735 Pretreatment of cells with dibutyryl cAMP or cytochalasin B completely abolished the [EDN] release *induced* by and EPO , suggesting that the effects of MBP and EPO are not due to cytotoxic lysis of the cells . Positive_regulation EDN2 MME 9595461 506038 High pericardial fluid levels of [endothelin] are not *caused* by altered activity in cardiac patients . Positive_regulation EDN2 MYO10 2183615 131916 [Endothelin] *increases* cytoplasmic calcium and phosphorylation in human myometrium . Positive_regulation EDN2 MYO16 2183615 131915 [Endothelin] *increases* cytoplasmic calcium and phosphorylation in human myometrium . Positive_regulation EDN2 MYO19 2183615 131914 [Endothelin] *increases* cytoplasmic calcium and phosphorylation in human myometrium . Positive_regulation EDN2 MYO6 2183615 131917 [Endothelin] *increases* cytoplasmic calcium and phosphorylation in human myometrium . Positive_regulation EDN2 NFATC3 15016802 1243413 The pro-hypertrophic basic helix-loop-helix protein p8 is degraded by the ubiquitin/proteasome system in a protein kinase B/Akt- and glycogen synthase kinase-3 dependent manner , whereas [endothelin] induction of p8 mRNA and renal mesangial cell hypertrophy *require* . Positive_regulation EDN2 NFKB1 15860794 1425759 MBP1 induced activation of neural nuclear factor (NF)-kappaB , from 10 min to 12 h , declining by 24 h , whereas [EDN] *induced* a short lived activation of . Positive_regulation EDN2 NFKB1 20399772 2267376 signaling *mediates* vascular smooth muscle [endothelin] type B receptor expression in resistance arteries . Positive_regulation EDN2 NOS1 9578518 503281 *Role* of in release of [endothelin] from cultured human endometrial cells . Positive_regulation EDN2 NOS2 9578518 503282 *Role* of in release of [endothelin] from cultured human endometrial cells . Positive_regulation EDN2 NOS3 9578518 503283 *Role* of in release of [endothelin] from cultured human endometrial cells . Positive_regulation EDN2 NPPA 9513855 492094 To investigate whether [endothelin] may *induce* increase in heart transplant recipients , we monitored daily ANP , endothelin , and related hormonal , biologic , and hemodynamic parameters before and during the first week after either heart transplantation ( n = 15 ) or coronary artery bypass grafting ( n = 10 ) . Positive_regulation EDN2 NPPC 8206631 261216 *upregulates* vascular [endothelin] type B receptors . Positive_regulation EDN2 NPY 9630349 512335 These data indicate that the *induced* effect does not involve either the endothelium derived vasodilator nitric oxide or the vasoconstrictor [endothelin] . Positive_regulation EDN2 PAF1 2051719 161806 In addition , [endothelin] *induced* a significant increase in the production of by isolated glomeruli ( Basal , 81 +/- 10 pg/mg protein ; endothelin , 10 ( -7 ) M , 140 +/- 18 pg/mg protein ) . Positive_regulation EDN2 PAF1 2689821 123946 Thus , [endothelin] is a highly toxic peptide with cardiotoxic effects , and may be *involved* in the pathogenesis of the sudden death . Positive_regulation EDN2 PEA15 9721757 528742 [Endothelin] *induces* a calcium dependent phosphorylation of in intact astrocytes : identification of Ser104 and Ser116 phosphorylated , respectively , by protein kinase C and calcium/calmodulin kinase II in vitro . Positive_regulation EDN2 PGF 21153099 407644 In contrast , and angiotensin II , both endogenous cardiac vasoconstrictors , *increased* [endothelin] production and overcame the inhibition induced by BNP and carba-prostacyclin . Positive_regulation EDN2 PLA2G1B 2492195 105548 *Activation* of by [endothelin] in cultured vascular smooth muscle cells . Positive_regulation EDN2 PLA2G1B 2492195 105554 The data herein implicate *activation* of by [endothelin] with subsequent metabolism of arachidonic acid via the lipoxygenase pathway . Positive_regulation EDN2 PLA2G1B 8304484 249013 Mechanism of [endothelin] *activation* of in rat renal medullary interstitial cells . Positive_regulation EDN2 PLA2G1B 8526939 336624 *Activation* of by the human [endothelin] receptor in Chinese hamster ovary cells involves Gi protein mediated calcium influx . Positive_regulation EDN2 PLA2G4A 8717070 378847 3 . [Endothelin] *activation* of is sensitive to ambient [Ca2+ ] i , is not contingent upon protein kinase C activation and is independent of PI-PLC stimulation , being coupled to the endothelin receptor in a yet to be determined manner . Positive_regulation EDN2 PLD1 8477817 218623 The *activation* of PLC or by [endothelin] in the three cell lines was mediated by the high affinity binding site ( nM range ) and was not significantly affected by either extracellular or intracellular Ca2+ . Positive_regulation EDN2 PLD1 8498538 220827 [Endothelin] *activation* of : dual modulation by protein kinase C and Ca2+ . Positive_regulation EDN2 PLD1 8717070 378875 4. *Activation* by [endothelin] of phosphatidylcholine-specific is under the dual regulation of protein kinase C and [Ca2+ ] i , with protein kinase C being the major regulator and [Ca2+ ] i playing a secondary , modulatory role . Positive_regulation EDN2 PLD2 8477817 218624 The *activation* of PLC or by [endothelin] in the three cell lines was mediated by the high affinity binding site ( nM range ) and was not significantly affected by either extracellular or intracellular Ca2+ . Positive_regulation EDN2 PLD2 8498538 220828 [Endothelin] *activation* of : dual modulation by protein kinase C and Ca2+ . Positive_regulation EDN2 PLD2 8717070 378876 4. *Activation* by [endothelin] of phosphatidylcholine-specific is under the dual regulation of protein kinase C and [Ca2+ ] i , with protein kinase C being the major regulator and [Ca2+ ] i playing a secondary , modulatory role . Positive_regulation EDN2 PLD3 8477817 218618 The *activation* of PLC or by [endothelin] in the three cell lines was mediated by the high affinity binding site ( nM range ) and was not significantly affected by either extracellular or intracellular Ca2+ . Positive_regulation EDN2 PLD3 8498538 220823 [Endothelin] *activation* of : dual modulation by protein kinase C and Ca2+ . Positive_regulation EDN2 PLD3 8717070 378871 4. *Activation* by [endothelin] of phosphatidylcholine-specific is under the dual regulation of protein kinase C and [Ca2+ ] i , with protein kinase C being the major regulator and [Ca2+ ] i playing a secondary , modulatory role . Positive_regulation EDN2 PLD4 8477817 218619 The *activation* of PLC or by [endothelin] in the three cell lines was mediated by the high affinity binding site ( nM range ) and was not significantly affected by either extracellular or intracellular Ca2+ . Positive_regulation EDN2 PLD4 8498538 220824 [Endothelin] *activation* of : dual modulation by protein kinase C and Ca2+ . Positive_regulation EDN2 PLD4 8717070 378872 4. *Activation* by [endothelin] of phosphatidylcholine-specific is under the dual regulation of protein kinase C and [Ca2+ ] i , with protein kinase C being the major regulator and [Ca2+ ] i playing a secondary , modulatory role . Positive_regulation EDN2 PLD5 8477817 218620 The *activation* of PLC or by [endothelin] in the three cell lines was mediated by the high affinity binding site ( nM range ) and was not significantly affected by either extracellular or intracellular Ca2+ . Positive_regulation EDN2 PLD5 8498538 220825 [Endothelin] *activation* of : dual modulation by protein kinase C and Ca2+ . Positive_regulation EDN2 PLD5 8717070 378873 4. *Activation* by [endothelin] of phosphatidylcholine-specific is under the dual regulation of protein kinase C and [Ca2+ ] i , with protein kinase C being the major regulator and [Ca2+ ] i playing a secondary , modulatory role . Positive_regulation EDN2 PLD6 8477817 218621 The *activation* of PLC or by [endothelin] in the three cell lines was mediated by the high affinity binding site ( nM range ) and was not significantly affected by either extracellular or intracellular Ca2+ . Positive_regulation EDN2 PLD6 8498538 220826 [Endothelin] *activation* of : dual modulation by protein kinase C and Ca2+ . Positive_regulation EDN2 PLD6 8717070 378874 4. *Activation* by [endothelin] of phosphatidylcholine-specific is under the dual regulation of protein kinase C and [Ca2+ ] i , with protein kinase C being the major regulator and [Ca2+ ] i playing a secondary , modulatory role . Positive_regulation EDN2 PTBP1 15528350 1332532 Additionally , [EDN] and hPR also *induced* phenotypic and functional maturation . Positive_regulation EDN2 PTBP2 15528350 1332529 Additionally , [EDN] and hPR also *induced* phenotypic and functional maturation . Positive_regulation EDN2 PTGS2 18516093 1918466 Taken together , we believe that hypoxia , but not the PR or , *regulate* gonadotropin induced [EDN2] expression in the periovulatory follicle . Positive_regulation EDN2 RELA 15860794 1425760 MBP1 induced activation of neural nuclear factor (NF)-kappaB , from 10 min to 12 h , declining by 24 h , whereas [EDN] *induced* a short lived activation of . Positive_regulation EDN2 RELA 20399772 2267377 signaling *mediates* vascular smooth muscle [endothelin] type B receptor expression in resistance arteries . Positive_regulation EDN2 REN 9124461 419560 Plasma catecholamine and [endothelin] levels also increased threefold , and activity *increased* twofold . Positive_regulation EDN2 RXFP1 19101597 2053696 Native porcine relaxin , but not the modified peptide affected *dependent* and GR-independent readouts : ERK-1/2 and Akt phosphorylation as well as up-regulation of Akt and [endothelin] type-B receptor . Positive_regulation EDN2 SETD2 22972036 2706273 The present study was designed to test the hypothesis that mediated transcriptional activation *contributes* to the increased expression of [ET-2] gene in response to hCG in rat ovarian granulosa cells (GCs) during gonadotropin induced superovulation . Positive_regulation EDN2 SHC1 7929159 274309 [Endothelin] *induces* tyrosine phosphorylation and GRB2 association of in astrocytes . Positive_regulation EDN2 SLC33A1 7735683 305397 nM , [endothelin-l] *induced* a small , sustained contraction ( 16 +/- 3 % Cmo ) and increased the standard EFS induced contraction by 19 +/- 2 % Cmax ( i.e. 1.95 fold , n = 5 , P < 0.01 ) . Positive_regulation EDN2 SLC33A1 9337215 458234 ACEI and AT1 Ang II blockade reduced LVEDD ( 4.68+/-0.07 cm ) and increased LVFS ( 25.2+/-0.9 % ) from pacing only ( P < .05 ) . Plasma norepinephrine and endothelin increased by more than fivefold with chronic pacing and remained elevated with AT1 Ang II blockade. Plasma norepinephrine was reduced from pacing-only values by more than twofold in the ACEI group and the combination group. ACEI and Ang II receptor blockade *reduced* plasma [endothelin] levels by > 50 % from rapid pacing values . Positive_regulation EDN2 SPESP1 15793357 1387010 The *induced* [EDN] release was found to be significantly inhibited when the ESP was pretreated with protease inhibitor cocktail or the cysteine protease inhibitor , E-64 . Positive_regulation EDN2 TCEA1 19393623 2075073 Thus , [endothelin] *induces* cortical neurite through the endothelin A receptor by a mechanism dependent on JNK . Positive_regulation EDN2 TGFA 22407503 2624376 *induces* [endothelin] receptor A expression in osteoarthritis . Positive_regulation EDN2 TGFB1 11210004 785625 *increases* the production of the vasoactive peptide [endothelin (ET)] in cultures of vascular endothelial cells ( EC ) and vascular smooth muscle cells ( VSMC ) , but the physiologic or pathologic significance of this regulation has not been determined . Positive_regulation EDN2 TGFB1 11343419 813942 Combined Angiotensin and [Endothelin] Receptor Blockade Attenuates Adverse Cardiac Remodeling Post-Myocardial Infarction in the Rat : Possible *Role* of . Positive_regulation EDN2 TGFB1 1317401 187911 The fact that [endothelin] secretion is *stimulated* by cytokines , growth factors , and is consistent with this role . Positive_regulation EDN2 TGFB1 1921240 168504 In the *presence* of a dose dependent increase of immunoreactive [endothelin] release was measured . Positive_regulation EDN2 TGFB1 2649101 108839 An enzyme linked immunosorbent assay revealed that the levels of [endothelin] in endothelial cell conditioned media was also *increased* by . Positive_regulation EDN2 TGFB1 2649101 108842 These results suggest that , secreted by activated platelets , is *involved* not only in wound healing , but in the regulation of local vascular tone by stimulating [endothelin] production in the endothelial cells . Positive_regulation EDN2 TGFB2 11210004 785626 *increases* the production of the vasoactive peptide [endothelin (ET)] in cultures of vascular endothelial cells ( EC ) and vascular smooth muscle cells ( VSMC ) , but the physiologic or pathologic significance of this regulation has not been determined . Positive_regulation EDN2 TGFB2 1317401 187912 The fact that [endothelin] secretion is *stimulated* by cytokines , growth factors , and is consistent with this role . Positive_regulation EDN2 TGFB2 1921240 168505 In the *presence* of a dose dependent increase of immunoreactive [endothelin] release was measured . Positive_regulation EDN2 TGFB3 11210004 785627 *increases* the production of the vasoactive peptide [endothelin (ET)] in cultures of vascular endothelial cells ( EC ) and vascular smooth muscle cells ( VSMC ) , but the physiologic or pathologic significance of this regulation has not been determined . Positive_regulation EDN2 TGFB3 1317401 187913 The fact that [endothelin] secretion is *stimulated* by cytokines , growth factors , and is consistent with this role . Positive_regulation EDN2 TGFB3 1921240 168506 In the *presence* of a dose dependent increase of immunoreactive [endothelin] release was measured . Positive_regulation EDN2 TLR1 19129482 2047903 Priming with the allergic mediators histamine , IL-4 , and most prominently IL-5 , augmented the *induced* IL-8 and [EDN] secretion , revealing an ability to sensitize eosinophils for TLR7 and TLR9 activation . Positive_regulation EDN2 TLR10 19129482 2047911 Priming with the allergic mediators histamine , IL-4 , and most prominently IL-5 , augmented the *induced* IL-8 and [EDN] secretion , revealing an ability to sensitize eosinophils for TLR7 and TLR9 activation . Positive_regulation EDN2 TLR2 19129482 2047904 Priming with the allergic mediators histamine , IL-4 , and most prominently IL-5 , augmented the *induced* IL-8 and [EDN] secretion , revealing an ability to sensitize eosinophils for TLR7 and TLR9 activation . Positive_regulation EDN2 TLR3 19129482 2047905 Priming with the allergic mediators histamine , IL-4 , and most prominently IL-5 , augmented the *induced* IL-8 and [EDN] secretion , revealing an ability to sensitize eosinophils for TLR7 and TLR9 activation . Positive_regulation EDN2 TLR4 19129482 2047906 Priming with the allergic mediators histamine , IL-4 , and most prominently IL-5 , augmented the *induced* IL-8 and [EDN] secretion , revealing an ability to sensitize eosinophils for TLR7 and TLR9 activation . Positive_regulation EDN2 TLR5 19129482 2047907 Priming with the allergic mediators histamine , IL-4 , and most prominently IL-5 , augmented the *induced* IL-8 and [EDN] secretion , revealing an ability to sensitize eosinophils for TLR7 and TLR9 activation . Positive_regulation EDN2 TLR6 19129482 2047912 Priming with the allergic mediators histamine , IL-4 , and most prominently IL-5 , augmented the *induced* IL-8 and [EDN] secretion , revealing an ability to sensitize eosinophils for TLR7 and TLR9 activation . Positive_regulation EDN2 TLR7 19129482 2047908 Priming with the allergic mediators histamine , IL-4 , and most prominently IL-5 , augmented the *induced* IL-8 and [EDN] secretion , revealing an ability to sensitize eosinophils for TLR7 and TLR9 activation . Positive_regulation EDN2 TLR8 19129482 2047909 Priming with the allergic mediators histamine , IL-4 , and most prominently IL-5 , augmented the *induced* IL-8 and [EDN] secretion , revealing an ability to sensitize eosinophils for TLR7 and TLR9 activation . Positive_regulation EDN2 TLR9 19129482 2047910 Priming with the allergic mediators histamine , IL-4 , and most prominently IL-5 , augmented the *induced* IL-8 and [EDN] secretion , revealing an ability to sensitize eosinophils for TLR7 and TLR9 activation . Positive_regulation EDN2 TNF 10750028 681340 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone , indicating that adenylate cyclase and *induce* [ET-2] synthesis by separate signalling pathways . Positive_regulation EDN2 TNF 10750028 681351 Studies using receptor selective TNFalpha mutants , ( 125 ( I-TNFalpha binding and TNF receptor mRNA showed that type-1 receptors *mediate* the [ET-2] response to TNFalpha . Positive_regulation EDN2 TNF 11786084 901238 BMP-7 represses the basal and *stimulated* expression of the pro-inflammatory cytokines IL-6 and IL-1beta , the chemokines MCP-1 and IL-8 , and the vasoconstrictor [ET-2] in PTEC . Positive_regulation EDN2 TNF 15928030 1420657 Endothelin is also elevated in preeclampsia and [endothelin] synthesis is *enhanced* by . Positive_regulation EDN2 TNF 17116693 1686260 Here we show that p8 , a small stress-inducible basic helix-loop-helix protein , is required for [endothelin-] and alpha-adrenergic agonist induced cardiomyocyte hypertrophy and for stimulated *induction* , in cardiac fibroblasts , of matrix metalloproteases ( MMPs ) 9 and 13-MMPs linked to general inflammation and to adverse ventricular remodeling in heart failure . Positive_regulation EDN2 TNF 19745821 2140047 We examined the effect of 17-hydroxyprogesterone caproate ( 17-OHP ) on *stimulated* [endothelin (ET)] production and hypertension during pregnancy . Positive_regulation EDN2 TNF 22207076 2549743 Activation of nuclear factor-?B pathway is responsible for induced *up-regulation* of [endothelin] B2 receptor expression in vascular smooth muscle cells in vitro . Positive_regulation EDN2 TNF 22249931 2569496 Bosentan , an endothelin receptor antagonist , ameliorates collagen induced arthritis : the *role* of in the induction of [endothelin] system genes . Positive_regulation EDN2 TNF 9466472 485587 We hypothesized that [endothelin (ET)] may be released in *response* to and that platelet activating factor (PAF) and cyclooxygenase products modulate TNF induced ET-1 release in vivo . Positive_regulation EDN2 TSLP 22838633 2640775 stimulation *resulted* in release of [EDN] , phosphorylation of STAT5 as well as promotion of viability and survival . Positive_regulation EDN2 UCN 15821006 1451621 These data suggest that the endogenous peptides *contribute* to the suppression of vascular tone and [renin-angiotensin-aldosterone/endothelin] activation in HF and thus , play a protective compensatory role in this disorder . Positive_regulation EDN2 VCAM1 10206185 606478 In the present study , [endothelin] alone did not *induce* the surface expression and mRNA accumulation of in human vascular endothelial cells , but inhibition of endogenous nitric oxide ( NO ) by N ( G ) -monomethyl-L-arginine enhanced the surface expression and mRNA accumulation of VCAM-1 stimulated by endothelin-1 . Positive_regulation EDN2 VCAM1 9651192 515484 In the *presence* of GM-CSF , ICAM-1 and caused significant release of [EOS derived neurotoxin (EDN)] . Positive_regulation EDN2 VEGFA 9207226 440741 Therefore , VEGF increased ECE-1 expression in BAEC , which suggests that ECE-1 induction by may be *involved* in [endothelin-system] upregulation under pathological conditions such as neointimal formation and atherosclerosis . Positive_regulation EDN2 WDR61 2051719 161807 In addition , [endothelin] *induced* a significant increase in the production of by isolated glomeruli ( Basal , 81 +/- 10 pg/mg protein ; endothelin , 10 ( -7 ) M , 140 +/- 18 pg/mg protein ) . Positive_regulation EDN2 WDR61 2689821 123947 Thus , [endothelin] is a highly toxic peptide with cardiotoxic effects , and may be *involved* in the pathogenesis of the sudden death . Positive_regulation EDN3 EDN2 8621208 359402 Moreover , the production of appears to be regulated at the mRNA transcription level , and expressions of ET-1 and [ET-3] are *regulated* independently . Positive_regulation EDN3 EDN2 8632332 361564 Cyclo [ -D-Asp-Pro-D-Val-Leu-D-Trp- ] blocked ET-1- and *induced* effects but not [ET-3-] , ACh- or phenyl-p-quinone induced effects . Positive_regulation EDN3 EPHB2 12475899 1037740 [Endothelin] *induced* a rapid phosphorylation of the mitogen activated protein kinase <(MAPK)/ERK> and increased collagen I gene activity in freshly isolated aortas . Positive_regulation EDN3 EPHB2 19575782 2111479 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Positive_regulation EDN3 IL1B 10395413 627457 Segments of human temporal artery were placed in organ culture for up to 4 days and examined for [endothelin] ET ( B ) receptor activity in the *presence* and absence of the pro-inflammatory cytokine by in vitro pharmacology and reverse transcriptase-polymerase chain reaction ( RT-PCR ) . Positive_regulation EDN3 IL1B 10764953 684169 Interferon-gamma ( 100 U/ml ) increased the immunoreactive-endothelin levels , but not immunoreactive-adrenomedullin levels , whereas ( 10 ng/ml ) *increased* immunoreactive-adrenomedullin levels , but not [immunoreactive-endothelin] levels . Positive_regulation EDN3 IL1B 1445301 205192 Intracellular signal transduction for *induced* [endothelin] production in human umbilical vein endothelial cells . Positive_regulation EDN3 IL1B 1445301 205195 The authors investigated the intracellular signal transduction for *induced* [endothelin (ET)] production by endothelial cells from cultured human umbilical vein ( HUVEC ) . Positive_regulation EDN3 IL1B 18524861 1939824 , but not interleukin-6 , *enhances* renal and systemic [endothelin] production in vivo . Positive_regulation EDN3 IL1B 7729539 302164 We report that is a potent *inducer* of [endothelin] receptor expression in cultured human vascular smooth muscle cells . Positive_regulation EDN3 PLAT 2125563 146736 [Endothelin-1 and -3] *induce* the release of and von Willebrand factor from endothelial cells . Positive_regulation EDN3 TLR7 19129482 2047918 Priming with the allergic mediators histamine , IL-4 , and most prominently IL-5 , augmented the *induced* IL-8 and [EDN] secretion , revealing an ability to sensitize eosinophils for TLR7 and TLR9 activation . Positive_regulation EDN3 TNF 15928030 1420658 Endothelin is also elevated in preeclampsia and [endothelin] synthesis is *enhanced* by . Positive_regulation EDN3 TNF 17116693 1686261 Here we show that p8 , a small stress-inducible basic helix-loop-helix protein , is required for [endothelin-] and alpha-adrenergic agonist induced cardiomyocyte hypertrophy and for stimulated *induction* , in cardiac fibroblasts , of matrix metalloproteases ( MMPs ) 9 and 13-MMPs linked to general inflammation and to adverse ventricular remodeling in heart failure . Positive_regulation EDN3 TNF 19745821 2140048 We examined the effect of 17-hydroxyprogesterone caproate ( 17-OHP ) on *stimulated* [endothelin (ET)] production and hypertension during pregnancy . Positive_regulation EDN3 TNF 22207076 2549744 Activation of nuclear factor-?B pathway is responsible for induced *up-regulation* of [endothelin] B2 receptor expression in vascular smooth muscle cells in vitro . Positive_regulation EDN3 TNF 22249931 2569497 Bosentan , an endothelin receptor antagonist , ameliorates collagen induced arthritis : the *role* of in the induction of [endothelin] system genes . Positive_regulation EDN3 TNF 9466472 485588 We hypothesized that [endothelin (ET)] may be released in *response* to and that platelet activating factor (PAF) and cyclooxygenase products modulate TNF induced ET-1 release in vivo . Positive_regulation EDNRA EDN2 19393623 2075080 Thus , *induces* cortical neurite elongation through the [endothelin A receptor] by a mechanism dependent on JNK . Positive_regulation EDNRA EDN2 20450830 2257213 In Experiment 3 , isometric tension analysis revealed that the contractile effect of was *mediated* by [endothelin receptor A (EDNRA)] , not B ( EDNRB ) . Positive_regulation EDNRA EDN2 8242252 236369 Thus , both [ETA] receptors and ETB receptors *mediate* the effects of the on neurotransmission . Positive_regulation EDNRA EDN2 8831102 385712 These investigations indicate that endothelin [ETA] receptors mediate vasoconstriction and ETB receptors *mediate* vasodilatation in feline cerebral resistance arterioles in vivo . Positive_regulation EDNRA TNF 11854220 913520 [ETA] did not *induce* and was a weak inducer of IL-1 beta , IL-6 , macrophage inflammatory protein 1 alpha ( MIP-1 alpha ) , and MIP-2 . Positive_regulation EDNRA TNF 1286882 207658 In contrast to LPS , [ETA] *induced* only low amounts of IL-6 and no detectable activities in peritoneal macrophage supernatants . Positive_regulation EDNRB EDN2 8049132 267426 Infusion of Sarafotoxin 6b , an ETB agonist , also increased the aldosterone content of the adrenal and stimulated the ouabain-sensitive sodium potassium ATPase in the zona glomerulosa , further indicating that the effect of is probably *mediated* by [ETB] or isopeptide non-specific endothelin receptor . Positive_regulation EDNRB EDN2 8242252 236372 Thus , both ETA receptors and [ETB] receptors *mediate* the effects of the on neurotransmission . Positive_regulation EDNRB EDN2 8831102 385716 These investigations indicate that ETA receptors mediate vasoconstriction and endothelin [ETB] receptors *mediate* vasodilatation in feline cerebral resistance arterioles in vivo . Positive_regulation EDNRB EDN2 8854203 388054 In the renal vasculature of anesthetized rats , it is suggested that vasoconstriction is mediated through both endothelin ETA- and ETB-receptors and that endothelin [ETB-receptors] may be also involved in vasodilating *responses* to peptides . Positive_regulation EDNRB PCDH8 21505449 2463736 Our data suggest that hemizygous loss of NUFIP1 and may *contribute* to psychomotor delay , deletion of MTLR1 to microcephaly and loss of [EDNRB] to feeding difficulties and deafness . Positive_regulation EDNRB TNF 9595426 505979 In contrast , on fibrin matrix both bFGF and *increased* [ETB] mRNA expression by 25 +/- 9-fold ( p < 0.05 ) and 68 +/- 19-fold ( p < 0.05 ) of control , respectively , suggesting a role for ETB in the vascular tube formation that occurs under these conditions . Positive_regulation EEC1 FAS 18342935 1886532 Since Fas and Fas ligand (FasL) are expressed in EEC and trophoblast cells respectively and mitogen activated protein kinases ( MAPKs ) mediate Fas induced apoptosis , the *roles* of and MAPK signaling in [trophoblast-EEC] interactions were studied . Positive_regulation EED ZFP57 20808772 2314032 Levels of both and PcG proteins inversely correlated with those of reactive oxygen species ( ROS ) in senescing MEFs , but the treatment of Zfp277 ( -/- ) MEFs with an antioxidant *restored* the binding of [PRC2] but not PRC1 to the Ink4a/Arf locus . Positive_regulation EEF1A1 TNF 18688046 1961023 In HUVECs , rapidly *increased* [eEF1A1] expression , which is maximal after 1 hour and persists for up to 48 hours . Positive_regulation EEF1A2 FBXO32 19406843 2128179 Further , inhibitors of the transfer of geranylgeranyl isoprene units to protein targets cause [statin] muscle damage and *induction* in cultured cells and in fish . Positive_regulation EFNA1 TNF 11278471 802567 *induction* of endothelial [ephrin A1] expression is mediated by a p38 MAPK- and SAPK/JNK dependent but nuclear factor-kappa B-independent mechanism . Positive_regulation EFNA1 TNF 11278471 802582 Although *induces* [ephrin A1] expression in endothelial cells , the signaling pathways mediating ephrin A1 induction remain unknown . Positive_regulation EFNA1 TNF 11278471 802583 In this study , we investigated the signaling mechanisms of *dependent* induction of [ephrin A1] in endothelial cells . Positive_regulation EFNA1 TNF 11278471 802585 Both TNFR1 and TNFR2 appear to be involved in regulating ephrin A1 expression in endothelial cells , because neutralizing antibodies to either TNFR1 or TNFR2 inhibited *induced* [ephrin A1] expression . Positive_regulation EFNA1 TNF 11278471 802614 These findings indicate that *induced* [ephrin A1] expression is mediated through JNK and p38 MAPK signaling pathways . Positive_regulation EFNA1 TNF 11278471 802615 Taken together , the results of our study demonstrated that *induction* of [ephrin A1] in endothelial cells by is mediated through both p38 MAPK and SAPK/JNK , but not p42/44 MAPK or NF-kappaB , pathways . Positive_regulation EFNB1 BDNF 21653848 2442136 Phosphorylation of [ephrin-B1] , but not EphB2 , was *induced* by both conditioning and application and was inhibited by postsynaptic injections of ephrin-B antibody . Positive_regulation EFNB1 EPHB1 12118063 964689 *induced* endothelial [ephrin-B1] tyrosine phosphorylation , migration and integrin mediated ( alpha ( v ) beta ( 3 ) and alpha ( 5 ) beta ( 1 ) ) attachment and promoted neovascularization , in vivo , in a mouse corneal micropocket assay . Positive_regulation EFNB1 EPHB1 12118063 964690 *Activation* of [ephrin-B1] by induced phosphorylation of p46 JNK but not ERK-1/2 or p38 MAPkinases . Positive_regulation EFNB1 EPHB1 14608666 1162298 Forward and reverse signaling *mediated* by tyrosine kinase receptors and their transmembrane [ephrin-B] ligands play important roles in axon pathfinding , yet little is known about the intracellular pathways involved . Positive_regulation EFNB1 EPHB1 15996027 1430133 *Stimulation* of [ephrin-B] signaling in ephrin-B1/2 expressing rat IEC-6-cells with recombinant resulted in a significant dose dependent acceleration of wound closure . Positive_regulation EFNB1 EPHB1 17255342 1691110 Recombinant [ephrinB1-Fc] , which *induces* receptor activation , enhanced bFGF induced tube formation in an in vitro aortic ring assay and promoted bFGF induced corneal angiogenesis in vivo in a corneal pocket assay . Positive_regulation EFNB1 EPHB1 18634608 1358623 In addition , we demonstrate that coated EphB2-Fc receptors , which are specific for ephrinB2/B3 ligands , induce dramatic changes in the contact and migratory properties of OPCs , indicating that axonal receptors *activate* [ephrinB] signaling in OPCs.Based on these findings , we propose that OPCs are characterized by an ephrin code , and that Eph-ephrin interactions between axons and OPCs control the distribution of OPCs in the optic axonal tracts , and the progress and arrest of their migration . Positive_regulation EFNB1 EPHB1 21235905 479025 [Ephrin-B1] *activation* of promotes assembly of these cells into capillary-like structures . Positive_regulation EFNB1 EPHB1 22475621 2715209 *Activation* of receptors by [ephrinB] ( efnB ) ligands on neuronal cell surface regulates important functions , including neurite outgrowth , axonal guidance , and synaptic plasticity . Positive_regulation EFNB1 EPHB2 14608666 1162299 Forward and reverse signaling *mediated* by tyrosine kinase receptors and their transmembrane [ephrin-B] ligands play important roles in axon pathfinding , yet little is known about the intracellular pathways involved . Positive_regulation EFNB1 EPHB2 17255342 1691111 Recombinant [ephrinB1-Fc] , which *induces* receptor activation , enhanced bFGF induced tube formation in an in vitro aortic ring assay and promoted bFGF induced corneal angiogenesis in vivo in a corneal pocket assay . Positive_regulation EFNB1 EPHB2 18634608 1358624 In addition , we demonstrate that coated EphB2-Fc receptors , which are specific for ephrinB2/B3 ligands , induce dramatic changes in the contact and migratory properties of OPCs , indicating that axonal receptors *activate* [ephrinB] signaling in OPCs.Based on these findings , we propose that OPCs are characterized by an ephrin code , and that Eph-ephrin interactions between axons and OPCs control the distribution of OPCs in the optic axonal tracts , and the progress and arrest of their migration . Positive_regulation EFNB1 EPHB2 21952679 2488088 In addition , and EphB3 play a cell-autonomous role in regulating the transitions of double negative to double positive cells and of double positive to single positive thymocytes and the lack of these molecules or their ligands [ephrin B1] and ephrin B2 *induces* profound alterations of the TEC maturation and in the arrangement of epithelial network . Positive_regulation EFNB1 EPHB2 22475621 2715210 *Activation* of receptors by [ephrinB] ( efnB ) ligands on neuronal cell surface regulates important functions , including neurite outgrowth , axonal guidance , and synaptic plasticity . Positive_regulation EFNB1 EPHB3 14608666 1162300 Forward and reverse signaling *mediated* by tyrosine kinase receptors and their transmembrane [ephrin-B] ligands play important roles in axon pathfinding , yet little is known about the intracellular pathways involved . Positive_regulation EFNB1 EPHB3 17255342 1691112 Recombinant [ephrinB1-Fc] , which *induces* receptor activation , enhanced bFGF induced tube formation in an in vitro aortic ring assay and promoted bFGF induced corneal angiogenesis in vivo in a corneal pocket assay . Positive_regulation EFNB1 EPHB3 18634608 1358625 In addition , we demonstrate that coated EphB2-Fc receptors , which are specific for ephrinB2/B3 ligands , induce dramatic changes in the contact and migratory properties of OPCs , indicating that axonal receptors *activate* [ephrinB] signaling in OPCs.Based on these findings , we propose that OPCs are characterized by an ephrin code , and that Eph-ephrin interactions between axons and OPCs control the distribution of OPCs in the optic axonal tracts , and the progress and arrest of their migration . Positive_regulation EFNB1 EPHB3 21952679 2488089 In addition , EphB2 and play a cell-autonomous role in regulating the transitions of double negative to double positive cells and of double positive to single positive thymocytes and the lack of these molecules or their ligands [ephrin B1] and ephrin B2 *induces* profound alterations of the TEC maturation and in the arrangement of epithelial network . Positive_regulation EFNB1 EPHB3 22475621 2715211 *Activation* of receptors by [ephrinB] ( efnB ) ligands on neuronal cell surface regulates important functions , including neurite outgrowth , axonal guidance , and synaptic plasticity . Positive_regulation EFNB1 EPHB4 14608666 1162301 Forward and reverse signaling *mediated* by tyrosine kinase receptors and their transmembrane [ephrin-B] ligands play important roles in axon pathfinding , yet little is known about the intracellular pathways involved . Positive_regulation EFNB1 EPHB4 17255342 1691113 Recombinant [ephrinB1-Fc] , which *induces* receptor activation , enhanced bFGF induced tube formation in an in vitro aortic ring assay and promoted bFGF induced corneal angiogenesis in vivo in a corneal pocket assay . Positive_regulation EFNB1 EPHB4 18634608 1358626 In addition , we demonstrate that coated EphB2-Fc receptors , which are specific for ephrinB2/B3 ligands , induce dramatic changes in the contact and migratory properties of OPCs , indicating that axonal receptors *activate* [ephrinB] signaling in OPCs.Based on these findings , we propose that OPCs are characterized by an ephrin code , and that Eph-ephrin interactions between axons and OPCs control the distribution of OPCs in the optic axonal tracts , and the progress and arrest of their migration . Positive_regulation EFNB1 EPHB4 22475621 2715212 *Activation* of receptors by [ephrinB] ( efnB ) ligands on neuronal cell surface regulates important functions , including neurite outgrowth , axonal guidance , and synaptic plasticity . Positive_regulation EFNB1 EPHB6 14608666 1162302 Forward and reverse signaling *mediated* by tyrosine kinase receptors and their transmembrane [ephrin-B] ligands play important roles in axon pathfinding , yet little is known about the intracellular pathways involved . Positive_regulation EFNB1 EPHB6 17255342 1691114 Recombinant [ephrinB1-Fc] , which *induces* receptor activation , enhanced bFGF induced tube formation in an in vitro aortic ring assay and promoted bFGF induced corneal angiogenesis in vivo in a corneal pocket assay . Positive_regulation EFNB1 EPHB6 18634608 1358627 In addition , we demonstrate that coated EphB2-Fc receptors , which are specific for ephrinB2/B3 ligands , induce dramatic changes in the contact and migratory properties of OPCs , indicating that axonal receptors *activate* [ephrinB] signaling in OPCs.Based on these findings , we propose that OPCs are characterized by an ephrin code , and that Eph-ephrin interactions between axons and OPCs control the distribution of OPCs in the optic axonal tracts , and the progress and arrest of their migration . Positive_regulation EFNB1 EPHB6 22475621 2715213 *Activation* of receptors by [ephrinB] ( efnB ) ligands on neuronal cell surface regulates important functions , including neurite outgrowth , axonal guidance , and synaptic plasticity . Positive_regulation EFNB1 FGFR1 10611251 656191 Here , we report that when we used ectopically expressed proteins , we found that an activated associated with and *induced* the phosphorylation of [ephrin B1] on tyrosine . Positive_regulation EFNB1 FGFR1 19005214 2016421 *induced* phosphorylation of [ephrinB1] modulates its interaction with Dishevelled . Positive_regulation EFNB1 FGFR2 10611251 656192 Here , we report that when we used ectopically expressed proteins , we found that an activated associated with and *induced* the phosphorylation of [ephrin B1] on tyrosine . Positive_regulation EFNB1 FGFR2 19005214 2016422 *induced* phosphorylation of [ephrinB1] modulates its interaction with Dishevelled . Positive_regulation EFNB1 FGFR3 10611251 656193 Here , we report that when we used ectopically expressed proteins , we found that an activated associated with and *induced* the phosphorylation of [ephrin B1] on tyrosine . Positive_regulation EFNB1 FGFR3 19005214 2016423 *induced* phosphorylation of [ephrinB1] modulates its interaction with Dishevelled . Positive_regulation EFNB1 FGFR4 10611251 656194 Here , we report that when we used ectopically expressed proteins , we found that an activated associated with and *induced* the phosphorylation of [ephrin B1] on tyrosine . Positive_regulation EFNB1 FGFR4 19005214 2016424 *induced* phosphorylation of [ephrinB1] modulates its interaction with Dishevelled . Positive_regulation EFNB1 GRIN2B 20979661 2348878 We have identified a novel pain cascade , in which IL-1ß production in cancer inoculated regions *induces* [ephrin B1] gene expression in DRGs and then ephrin B1 enhances the tyrosine phosphorylation of via Eph B receptor in the spinal cord . Positive_regulation EFNB1 IL1A 20979661 2348879 We have identified a novel pain cascade , in which production in cancer inoculated regions *induces* [ephrin B1] gene expression in DRGs and then ephrin B1 enhances the tyrosine phosphorylation of NR2B via Eph B receptor in the spinal cord . Positive_regulation EFNB1 IL1A 21116687 2389937 This PRL concentration ( comparable to plasma PRL levels in lactation ) also *induced* the upregulation of monocyte chemoattractant protein (MCP)-1 , cyclooxygenase (Cox)-2 , and [ephrin-B1] , whereas a higher concentration ( 500 ng/ml ) was required to upregulate tumor necrosis factor (TNF)-a and . Positive_regulation EFNB1 NOTCH1 19332065 2094100 In the IEC-6 cells , signaling *activated* the expression of [EphrinB1] in an Hes1 independent manner , but down-regulated the expression of EphB2 through the GSK3beta mediated inhibition of beta-catenin . Positive_regulation EFNB1 NOTCH2 19332065 2094101 In the IEC-6 cells , signaling *activated* the expression of [EphrinB1] in an Hes1 independent manner , but down-regulated the expression of EphB2 through the GSK3beta mediated inhibition of beta-catenin . Positive_regulation EFNB1 NOTCH3 19332065 2094102 In the IEC-6 cells , signaling *activated* the expression of [EphrinB1] in an Hes1 independent manner , but down-regulated the expression of EphB2 through the GSK3beta mediated inhibition of beta-catenin . Positive_regulation EFNB1 NOTCH4 19332065 2094103 In the IEC-6 cells , signaling *activated* the expression of [EphrinB1] in an Hes1 independent manner , but down-regulated the expression of EphB2 through the GSK3beta mediated inhibition of beta-catenin . Positive_regulation EFNB1 PI3 14576067 1199882 It also enhances Rap1 activation without requiring ADP secretion , [ephrinB1] phosphorylation , or the *activation* of and Src . Positive_regulation EFNB1 RHO 12546821 1051158 Rapid induction of dendritic spine morphogenesis by trans-synaptic [ephrinB-EphB] receptor *activation* of the kalirin . Positive_regulation EFNB1 SLC2A4RG 12546821 1051159 Rapid induction of dendritic spine morphogenesis by trans-synaptic [ephrinB-EphB] receptor *activation* of the kalirin . Positive_regulation EFNB1 SRC 14576067 1199881 It also enhances Rap1 activation without requiring ADP secretion , [ephrinB1] phosphorylation , or the *activation* of PI3-kinase and . Positive_regulation EFNB1 TNF 21116687 2389936 This PRL concentration ( comparable to plasma PRL levels in lactation ) also *induced* the upregulation of monocyte chemoattractant protein (MCP)-1 , cyclooxygenase (Cox)-2 , and [ephrin-B1] , whereas a higher concentration ( 500 ng/ml ) was required to upregulate and interleukin (IL)-1 . Positive_regulation EFNB2 EPHB2 14608666 1162304 Forward and reverse signaling *mediated* by tyrosine kinase receptors and their transmembrane [ephrin-B] ligands play important roles in axon pathfinding , yet little is known about the intracellular pathways involved . Positive_regulation EFNB2 EPHB2 16511561 1535639 Here we show that *stimulates* a metalloproteinase cleavage of [ephrinB2] , producing a carboxy-terminal fragment that is further processed by PS1/gamma-secretase to produce intracellular peptide ephrinB2/CTF2 . Positive_regulation EFNB2 EPHB2 16511561 1535657 PS1 FAD and gamma-secretase dominant negative mutants inhibited the *induced* cleavage of [ephrinB2] and Src autophosphorylation , raising the possibility that FAD mutants interfere with the functions of Src and ephrinB2 in the CNS . Positive_regulation EFNB2 EPHB2 18634608 1358629 In addition , we demonstrate that coated EphB2-Fc receptors , which are specific for ephrinB2/B3 ligands , induce dramatic changes in the contact and migratory properties of OPCs , indicating that axonal receptors *activate* [ephrinB] signaling in OPCs.Based on these findings , we propose that OPCs are characterized by an ephrin code , and that Eph-ephrin interactions between axons and OPCs control the distribution of OPCs in the optic axonal tracts , and the progress and arrest of their migration . Positive_regulation EFNB2 EPHB2 18713744 1974757 We found that is cleaved by MMPs both in vitro and in vivo , and that this cleavage is *induced* by interaction with its ligand [ephrin-B2] . Positive_regulation EFNB2 EPHB2 21746865 2484345 Presenilin1/gamma-secretase promotes the *induced* phosphorylation of [ephrinB2] by regulating phosphoprotein associated with glycosphingolipid enriched microdomains/Csk binding protein . Positive_regulation EFNB2 EPHB2 21746865 2484346 *induced* tyrosine phosphorylation of [ephrinB2] depends on PAG/Cbp because EphB2 can not increase ephrinB2 phosphorylation in cells treated with anti-PAG siRNA or in PAG/Cbp-knockout ( KO ) cells . Positive_regulation EFNB2 EPHB2 21746865 2484350 Furthermore , in contrast to WT PS1 , familial Alzheimer disease ( FAD ) PS1 mutants expressed in PS1-KO mouse embryonic fibroblasts inhibited both the *induced* dephosphorylation of PAG/Cbp and the phosphorylation of [ephrinB2] . Positive_regulation EFNB2 EPHB2 21952679 2488090 In addition , and EphB3 play a cell-autonomous role in regulating the transitions of double negative to double positive cells and of double positive to single positive thymocytes and the lack of these molecules or their ligands ephrin B1 and [ephrin B2] *induces* profound alterations of the TEC maturation and in the arrangement of epithelial network . Positive_regulation EFNB2 EPHB2 22475621 2715215 *Activation* of receptors by [ephrinB] ( efnB ) ligands on neuronal cell surface regulates important functions , including neurite outgrowth , axonal guidance , and synaptic plasticity . Positive_regulation EFNB2 JAG1 16430858 1521533 In co-culture experiments using EC and either Dll4- or Jagged1 expressing cells , we found that Dll4 stimulation but not markedly *induced* [ephrinB2] expression . Positive_regulation EFNB2 TCN1 21555368 2449354 Production and persistence of these pain behaviors are well correlated with *induced* upregulation of EphB1 receptor and its ligand [ephrinB2] in the dorsal horn and primary sensory neurons . Positive_regulation EFNB3 EPHB2 14608666 1162309 Forward and reverse signaling *mediated* by tyrosine kinase receptors and their transmembrane [ephrin-B] ligands play important roles in axon pathfinding , yet little is known about the intracellular pathways involved . Positive_regulation EFNB3 EPHB2 18634608 1358634 In addition , we demonstrate that coated EphB2-Fc receptors , which are specific for ephrinB2/B3 ligands , induce dramatic changes in the contact and migratory properties of OPCs , indicating that axonal receptors *activate* [ephrinB] signaling in OPCs.Based on these findings , we propose that OPCs are characterized by an ephrin code , and that Eph-ephrin interactions between axons and OPCs control the distribution of OPCs in the optic axonal tracts , and the progress and arrest of their migration . Positive_regulation EFNB3 EPHB2 22475621 2715220 *Activation* of receptors by [ephrinB] ( efnB ) ligands on neuronal cell surface regulates important functions , including neurite outgrowth , axonal guidance , and synaptic plasticity . Positive_regulation EGF ADRB2 10196213 604411 However , endocytosis does not appear to be required for alpha2-adrenergic , [epidermal growth factor] , lysophosphatidic acid , or mediated p42/p44 MAP kinase *activation* in COS-1 cells . Positive_regulation EGF ANGPT1 16917117 1632855 added to P-ECs from patients with iPAH *increased* the production of endothelin-1 (ET-1) and serotonin , but not of platelet derived growth factor-BB or [epidermal growth factor] , and increased the amount of mRNA encoding tryptophan hydroxylase-1 ( the rate limiting enzyme of serotonin synthesis ) , preproET-1 , and ET-1 converting enzyme . Positive_regulation EGF CAPN8 10402474 628958 IP-10 also prevented [EGF-] *induced* activation ( reduced by 71 +/- 7 % ) . Positive_regulation EGF CAPN8 10644690 661337 [EGF] *induced* rapid activation of that was preventable by molecular inhibition of the Ras-Raf-MEK but not phospholipase Cgamma signaling pathway , and calpain was stimulated by transfection of constitutively active MEK . Positive_regulation EGF CAPN8 15713646 1373984 These data demonstrate that while both [EGF-] and IP-9 induced motility in keratinocytes *requires* activity , the isoform of calpain triggered depends on the nature of the receptor for the particular ligand . Positive_regulation EGF CCND1 11375998 842338 Moreover , betaVLDL plus [EGF] synergistically *induce* expression and down-regulate p27 ( KIP1 ) expression . Positive_regulation EGF CCND1 11590324 869345 [Epidermal growth factor] *induces* in human pancreatic carcinoma : evidence for a cyclin D1-dependent cell cycle progression . Positive_regulation EGF CCND1 19443725 2136032 [EGF] *induced* increases in paxillin Ser-126 phosphorylation and expression through transient Erk1/2 phosphorylation . Positive_regulation EGF CCND1 21505178 2458336 We also found that [EGF] *induced* increased expression , which plays a critical role in bronchial hyperplasia ; Positive_regulation EGF CCND1 24008581 2845916 In primary hepatocyte cultures , [EGF] or TGFa binding to EGF receptor activates Erk1/2 and PI3K pathways , *induces* and thus initiates DNA synthesis . Positive_regulation EGF CCND1 9568675 501314 [Epidermal growth factor] *induces* in a human prostate cancer cell line . Positive_regulation EGF CLU 10644902 661650 In animal models of obstructive nephropathy and PKD , the renal tubular expression of [epidermal growth factor] is suppressed , and expression of is *increased* , both of which suggest arrested maturation or dedifferentiation of the tubular cell . Positive_regulation EGF CTGF 11148815 761012 FCS , TGF-beta 1 , TGF-beta 3 , bFGF , and [EGF] *induced* an upregulation of gene expression in RVEC in a time dependent manner . Positive_regulation EGF EPHB2 11046147 743134 In contrast , [epidermal growth factor] fails to promote a morphogenic program and *induces* transient Gab1 phosphorylation and activation . Positive_regulation EGF EPHB2 11149911 780466 The additional finding that [EGF] *induces* and EGR-1 in a PKC independent manner and that this signal is not sufficient to up-regulate TF emphasizes the importance of a VEGF-specific signaling pattern for the induction of TF . Positive_regulation EGF EPHB2 11287413 819804 Moreover , [epidermal growth factor] , which *induced* a transient ( 1 h ) activation of extracellular signal regulated kinase ( ) in MDCK cells , only slightly increased integrin alpha(2) expression and failed to trigger cell scattering . Positive_regulation EGF EPHB2 11758828 887689 We examined whether [EGF receptor (EGF-R)] is involved in ERK activation and whether activation *triggers* epithelial proliferation in PHT gastric mucosa . Positive_regulation EGF EPHB2 12384223 998623 Moreover , we show that the signaling cascade initiated by substance P or EGF are indistinguishable , including the activation of the [EGF] receptor , the *activation* of , and the final stimulation of Egr-1 biosynthesis . Positive_regulation EGF EPHB2 12706116 1082478 In PC12 cells , NGF and [EGF] *induce* a rapid translocation of that requires Ras and Mek . Positive_regulation EGF EPHB2 12767047 1094247 In hepatocytes at 24 h of culturing ( mid/late G ( 1 ) ) with 20,000 cells per cm ( 2 ) , [EGF] *induced* strong phosphorylation of the EGF receptor , as well as Shc and , and stimulated DNA synthesis , but did not activate Stat5b , although the Stat5b response to GH or PRL was retained . Positive_regulation EGF EPHB2 12876381 1115371 Role of ERK , p38 and PI3-kinase in [EGF] receptor *mediated* mitogenic signalling in cultured rat hepatocytes : requirement for sustained activation . Positive_regulation EGF EPHB2 14737112 1202826 Upon further analysis , we found that sensitivity to [epidermal growth factor] *activation* of phosphorylation was significantly higher , and that cholesterol was significantly depleted , in cells overexpressing HMGA1a . Positive_regulation EGF EPHB2 15028221 1222954 For example , the mitogen [EGF] *induces* a transient ERK activation , whereas the neurotrophin NGF induces prolonged activation . Positive_regulation EGF EPHB2 15150258 1252313 However , *activation* of by [epidermal growth factor] or carbachol were not suppressed by inhibition of CaMKK , indicating specificity for this `` cross-talk . '' Positive_regulation EGF EPHB2 15310281 1285074 The addition of SB203580 prolonged the transient *activation* of both B-Raf and by [EGF] alone . Positive_regulation EGF EPHB2 15899852 1408873 Phosphorylation at Raf-1 S43 and S259 by PKA only weakly inhibited [EGF] *activation* of Raf-1 and when cells maintained high Raf-1 S338 phosphorylation . Positive_regulation EGF EPHB2 16135787 1450381 Analyses with selective IQGAP1 mutant constructs indicated that MEK binding is crucial for IQGAP1 to modulate [EGF] *activation* of . Positive_regulation EGF EPHB2 16150920 1539190 [EGF] also *induced* robust activation in primary porcine mesenchymal stem cells . Positive_regulation EGF EPHB2 16785991 1654026 Our data suggest that PRL synergistically augments [EGF] signaling in T47D breast cancer cells at least in part by lessening EGF induced EGFR downregulation and that this effect *requires* PRL induced activity and threonine phosphorylation of EGFR . Positive_regulation EGF EPHB2 17113976 1651259 *Activation* of by both ET-1 and [EGF] was abolished by inhibition of Src , indicating its central role in ET-1 signaling in BAG cells . Positive_regulation EGF EPHB2 17295209 1771796 [EGF] *activation* of prior to irradiation was associated with a marked increase in PARP activation and decreased survival in both cell lines . Positive_regulation EGF EPHB2 17332776 1726546 Interferon alpha (IFNalpha) induces both apoptosis and a counteracting [epidermal growth factor] *dependent* survival response in cancer cells . Positive_regulation EGF EPHB2 17372305 1713812 however , selective inhibition of the ErbB2 receptor (EB2R) with AG825 or small interfering RNA ( siRNA ) blocked low but not high [EGF] *activation* of and p38 . Positive_regulation EGF EPHB2 17392517 1741859 It does not affect [EGF] receptor autophosphorylation or *activation* of , but it inhibits transphosphorylation of Tyr845 and activation of signal transducers and activators of transcription 5 . Positive_regulation EGF EPHB2 17474086 1772246 These results indicate that phosphorylation and *activation* of extracellular signal regulated protein kinase , elevated levels of intracellular Ca ( 2+ ) and the transactivation of the [EGF] receptor are essential for BzATP induced upregulation of Egr-1 . Positive_regulation EGF EPHB2 17483331 1739062 Knockdown of Brk by stable expression of short hairpin RNA ( shRNA ) in T47D breast cancer cells decreases proliferation and blocks [epidermal growth factor (EGF)-] and heregulin *induced* activation of Rac GTPase , extracellular signal regulated kinase ( ) 5 , and p38 mitogen activated protein kinase (MAPK) but not Akt , ERK1/2 , or c-Jun NH ( 2 ) -terminal kinase . Positive_regulation EGF EPHB2 19385051 2069281 [EGF] also *induced* the phosphorylation of EGFR , , and STAT-3 , and these effects were inhibited by the EGFR inhibitor , AG1478 . Positive_regulation EGF EPHB2 20473309 2269504 MyD88 ( myeloid differentiation primary response gene 88 ) -independent *activation* of by [epidermal growth factor (EGF)] increased p-ERK and c-Myc and restored the multiple intestinal neoplasia ( Min ) phenotype in Apc ( min/+ ) /Myd88 ( -/- ) mice . Positive_regulation EGF EPHB2 20493519 2270236 In the cytosol , [EGF] induces transient and HRG *induces* sustained activation . Positive_regulation EGF EPHB2 20810616 2341736 We found that nanomolar concentrations of Sorafenib reduced the basal activity of ERK , *inhibited* cAMP dependent activation of B-Raf and signaling , and caused a concentration dependent inhibition of cell proliferation induced by cAMP , [epidermal growth factor] , or the combination of the two agonists . Positive_regulation EGF EPHB2 21081118 2383043 [EGF] *induces* CREB and activation at the wall of the mouse lateral ventricles . Positive_regulation EGF EPHB2 21518868 2428894 EGF activates NF-?B and stimulates phosphorylation of FER , [EGF receptor (EGFR)] , and ERK p42/p44 , and decreased expression of FER or inhibition of phosphorylation *inhibits* the EGF induced activation of NF-?B . Positive_regulation EGF EPHB2 22033246 2527431 [EGF] *induced* the phosphorylation of EGFR , smad3 , , and JNK , and MMP-9 expression was decreased by the EGFR inhibitor , AG1478 . Positive_regulation EGF EPHB2 22033920 2516783 Finally , we demonstrated that [EGF] *induced* activation of and interaction between PML and phosphorylated ERK resulting in a decrease in PML protein levels . Positive_regulation EGF EPHB2 22198386 2575031 In addition to strong *activation* of by [EGF] , and AKT by serum , early transcription remarkably differed : while EGF induced early growth response-1 (EGR1) , and this was required for migration , serum induced c-Fos and FosB to enhance proliferation . Positive_regulation EGF EPHB2 23180942 2704352 [Epidermal growth factor (EGF)] at 10 ng/mL *induced* the phosphorylation of EGFR , AKT and in both cell lines with similar kinetics . Positive_regulation EGF EPHB2 23482085 2771836 The in vitro results showed that [EGF] *induces* the upregulation of KCa3.1 and in HUVECs and that this upregulation is suppressed by PD98059 . Positive_regulation EGF EPHB2 24188029 2921079 Here , we show that HB-EGF *induced* [EGF receptor (EGFR)] activation by Y1068 phosphorylation , pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation EGF EPHB2 8524249 335114 This finding suggests that Grb2 is the only adapter involved in the *activation* of by [EGF] . Positive_regulation EGF EPHB2 8885243 391077 [EGF] *induced* both and SAPK activity in JEG-3 cells . Positive_regulation EGF EPHB2 9765228 537916 phosphorylation was also *induced* by [epidermal growth factor (EGF)] ( 100 ng/ml ) . Positive_regulation EGF EPHB2 9933031 589200 On the other hand , an obligatory tyrosine phosphorylation step for activation of ERK was indicated by the use of protein tyrosine kinase inhibitors , which profoundly inhibited the *activation* of by [EGF] , Ang II , and PMA . Positive_regulation EGF F2R 15780084 1385231 These responses which are dependent on its protease activity appear not to be mediated by activation , the autocrine action of thrombin induced TGF-beta1 secretion , MMP activation , or [EGF] receptor *transactivation* . Positive_regulation EGF FAS 10509790 650976 Flowcytometric analyses demonstrated that [EGF] did not *induce* expression on the cell surface while expressions of the EGF receptor were down-regulated . Positive_regulation EGF FAS 10924745 718410 Flow cytometric analyses demonstrated that TGF-beta1 , IL-1beta , and [EGF] did not *induce* expression on the cell surface . Positive_regulation EGF FOXO1 11030146 740084 FKHR immunoblotting after purification of nuclear and cytoplasmic proteins showed that [EGF] *induced* a simultaneous increase of in the cytoplasm and decrease in the nucleus . Positive_regulation EGF HBEGF 10425274 632815 These results indicate that EGF and possess different functions in RGM-1 cells and that [EGF] *acts* as a mediator of both cell maturation and apoptosis in these cells . Positive_regulation EGF HBEGF 11116149 810664 BB2116 as well as HB-EGF neutralizing antibody inhibited the EGF receptor transactivation by AngII , suggesting a critical *role* of in the metalloprotease dependent [EGF] receptor transactivation . Positive_regulation EGF HBEGF 15277724 1277258 Recently , similar transactivation of EGF receptor by a GPCR agonist has been reported in various organs , indicating that [EGF] receptor *transactivation* by might play the general role of pharmacological reaction by AGII . Positive_regulation EGF HBEGF 16020536 1435108 Recent evidence indicates that [EGF] receptor *transactivation* by contributes to hypertrophic signaling in cardiomyocytes . Positive_regulation EGF HBEGF 16141218 1454836 Heparin binding EGF-like growth factor ( ) is a member of the EGF family of growth factors that binds to and *activates* the [EGF receptor (EGFR)] and ERBB4 . Positive_regulation EGF HBEGF 19939201 2217261 Since *activates* [EGF] receptors which have been implicated in tumor development , we examined the effects of HB-EGF overexpression in the intestine . Positive_regulation EGF HBEGF 20071362 2264698 Phosphorylation changes induced by direct mediated [EGF] receptor *activation* were typically weaker and only detected on a subset of LPA regulated sites , indicating signal integration among EGF receptor transactivation and other LPA triggered pathways . Positive_regulation EGF HBEGF 21544358 407744 These findings suggest that *activates* the [EGF] receptor in human pancreatic cancer cells , but that it is not involved in enhancing the biological aggressiveness of this malignancy in vivo . Positive_regulation EGF HBEGF 24188029 2921078 Here , we show that *induced* [EGF receptor (EGFR)] activation by Y1068 phosphorylation , Mapk/Erk pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation EGF HBEGF 8060360 268230 Heparin binding EGF-like growth factor ( ) is a polypeptide with an apparent molecular weight of 22 kilodalton that is related to epidermal growth factor (EGF) and that binds and *activates* the [EGF] receptor . Positive_regulation EGF ID1 21740235 2591548 [EGF] also *induced* changes in the expression of Id genes , Id2 , and Id4 in the SVZ . Positive_regulation EGF IL1B 10537052 562959 Among interleukin-1beta (IL-1beta) , fibroblast growth factor-2 , epidermal growth factor (EGF) , amyloid beta1-42 , and 50 % O2 , only EGF and altered the level of GIF in confluent astrocytes : [EGF] *increased* both GIF mRNA and protein , and IL-1beta decreased GIF mRNA , but did not alter GIF protein . Positive_regulation EGF IL1B 11179516 784769 *induced* [EGF] receptor tyrosine phosphorylation started at 5 min and peaked at 10 min and remained elevated up to 40 min post IL-1 beta treatment . Positive_regulation EGF IL1B 11179516 784770 EGF receptor kinase inhibitor PD153035 and AG1478 inhibited *induced* [EGF] receptor tyrosine phosphorylation . Positive_regulation EGF IL1B 15474551 1319081 Gastrin and *stimulated* the secretion of heparin binding [epidermal growth factor] and amphiregulin but not transforming growth factor-alpha from parietal cells . Positive_regulation EGF IL1B 19210917 2033986 [EGF] *induced* an increase in the rate of in vitro maturation ( P < 0.05 ) , whereas had a limited effect . Positive_regulation EGF IL1B 2605216 123670 In addition , using chimeric constructs of the stromelysin promoter linked to the bacterial gene chloramphenicol acetyltransferase (CAT) , we show that the elements required for the tumor promoter phorbol myristate acetate ( PMA ) , [epidermal growth factor (EGF)] , and *induction* are contained on a 307 base pair fragment which includes approximately 270 base pairs ( bp ) of 5'-flanking DNA . Positive_regulation EGF IL1B 7905817 245842 and tumor necrosis factor alpha (TNF-alpha) *increased* the [EGF] receptor surface expression only on BT-20 breast carcinoma cells . Positive_regulation EGF IL1B 9284956 451874 Expression of KGF transcript was down-regulated by [EGF] , TGF-alpha , and PDGF-BB , was markedly *up-regulated* by , and was more pronounced in limbal than in corneal fibroblasts . Positive_regulation EGF KRT38 8612697 353347 Specifically , while [EGF] *induces* expression of K6 and K16 genes , retinoic acid suppresses their expression , and when both mediators are present simultaneously , the level of expression is intermediate , a product of both signals . Positive_regulation EGF MAP2K6 12037663 949288 The activation of hTERT mRNA expression by [EGF] was specifically *blocked* by inhibitor , and in vitro kinase assays demonstrated that ERK is activated in response to EGF . Positive_regulation EGF MAP2K6 19022560 2029190 Furthermore , *activation* of Raf-1 , and the ERKs by either [EGF] or Ras ( G12R ) was inhibited by NM23H2 overexpression . Positive_regulation EGF MAP2K6 20810616 2341742 We found that nanomolar concentrations of Sorafenib reduced the basal activity of ERK , *inhibited* cAMP dependent activation of B-Raf and signaling , and caused a concentration dependent inhibition of cell proliferation induced by cAMP , [epidermal growth factor] , or the combination of the two agonists . Positive_regulation EGF MAP2K6 21440529 2417046 The specific inhibitor , U0126 , significantly *blocks* [EGF] and TGF-a mediated ERK1/2 activation and subsequent MMP1 induction in SK-BR3 cells . Positive_regulation EGF MAP2K6 21821245 2485205 EGF stimulation was inhibited by AG1478 , an [EGF receptor (EGFR)] *inhibitor* and PD98059 , a mitogen activated protein kinase (MAPK) kinase ( ) inhibitor . Positive_regulation EGF MAP2K6 9535909 497294 [EGF] and lysophosphatidic acid induced phosphorylation on connexin-43 and the down-regulation of gap junctional communication in EGF treated cells were *blocked* by a specific inhibitor ( PD98059 ) that prevented activation of MAP kinase . Positive_regulation EGF MMP28 15780084 1385230 These responses which are dependent on its protease activity appear not to be mediated by PAR-1 activation , the autocrine action of thrombin induced TGF-beta1 secretion , activation , or [EGF] receptor *transactivation* . Positive_regulation EGF MMP28 20739465 2375196 Hypertonicity induced [EGF receptor (EGFR)] transactivation was *suppressed* by preincubating HCECs with capsazepine , matrix metalloproteinase 1 (MMP1) inhibitor TIMP-1 , broad-spectrum inhibitor GM 6001 , heparin bound (HB)-EGF inhibitor CRM 197 , or EGFR inhibitor AG 1478 . Positive_regulation EGF MMP7 10398277 627897 [EGF] *induces* the expression of in the human prostate adenocarcinoma cell line , LNCaP . Positive_regulation EGF MMP7 15780084 1385246 These responses which are dependent on its protease activity appear not to be mediated by PAR-1 activation , the autocrine action of thrombin induced TGF-beta1 secretion , activation , or [EGF] receptor *transactivation* . Positive_regulation EGF MMP7 20739465 2375211 Hypertonicity induced [EGF receptor (EGFR)] transactivation was *suppressed* by preincubating HCECs with capsazepine , matrix metalloproteinase 1 (MMP1) inhibitor TIMP-1 , broad-spectrum inhibitor GM 6001 , heparin bound (HB)-EGF inhibitor CRM 197 , or EGFR inhibitor AG 1478 . Positive_regulation EGF MSX1 10633853 576660 However , in contrast to BMPs , [EGF] did not *induce* , Msx-2 , and Bmp-4 , but modulated the effects of BMPs on the expression of Msx-1 and Msx-2 in these mesenchymes . Positive_regulation EGF MSX1 9541209 498046 [EGF] does not *induce* and Msx-2 in dental mesenchyme . Positive_regulation EGF MUC16 21442679 2421922 suppress [epidermal growth factor-] and phorbol ester *induced* MUC5AC production and gene expression from human airway epithelial cells . Positive_regulation EGF OLFM4 21048224 2344477 regulation by estrogen in the human endometrium *requires* [epidermal growth factor] signaling . Positive_regulation EGF PLAT 1654897 166174 [Epidermal growth factor (EGF)] *induces* tubular formation of cultured human omental microvascular endothelial ( HOME ) cells and EGF also stimulates cell migration as well as expression of . Positive_regulation EGF PLAT 7679996 211336 [EGF] and TGF-alpha *induced* expression of in HOME cells , while IGF-1 and HGF did not . Positive_regulation EGF PLAU 12384986 999491 [EGF] also *induced* increased expression of and uPA receptor (uPAR) proteins and mRNA , as well as transcription factor activator protein-1 (AP-1)-DNA binding . Positive_regulation EGF SPHK1 17855624 1858286 [EGF] *induced* rapid phosphorylation of c-Src and PKCdelta and concomitant translocation of PKCdelta as well as to the plasma membrane . Positive_regulation EGF SPHK1 19633297 2132097 IGFBP-3 potentiated EGF stimulated [EGF] receptor activation and DNA synthesis , and this was *blocked* by inhibitors of activity or small interference RNA mediated silencing of SphK1 , but not SphK2 , expression . Positive_regulation EGF SPHK1 21848514 2510098 However , inhibition did *diminish* [EGF] ( epidermal growth factor ) -driven increases in S1P levels and Akt ( also known as protein kinase B ) /ERK ( extracellular-signal regulated kinase ) phosphorylation . Positive_regulation EGF SPHK1 9395290 468328 In contrast , [epidermal growth factor] and insulin-like growth factor-1 , which stimulate proliferation of PC12 cells , *induced* only small and transient increases in activity . Positive_regulation EGF TF 3281751 91983 Optimal growth of HCT 116 cells was seen in the *presence* of insulin and , while maximum proliferation of HCT 116a cells depended on combined insulin , transferrin , and [EGF] . Positive_regulation EGF TNF 11460304 838801 Moreover , *increased* viral replication in the presence of [EGF] but not TGF-alpha . Positive_regulation EGF TNF 1378752 190851 Resolution of tryptic phosphopeptides from EGF receptor demonstrated that *induced* phosphorylation of [EGF] receptor was similar , but not identical , to profiles obtained from EGF treated cells and distinct when compared to the actions of phorbol ester . Positive_regulation EGF TNF 1425452 202283 Whereas IL-2 ( 0.1-100 ng/ml ) did not affect [ 3H ] thymidine incorporation , *stimulated* [ 3H ] thymidine incorporation by itself and reproduced the actions of IL-1 to act synergistically with insulin , [EGF] , or FGF . Positive_regulation EGF TNF 1512472 196695 Human ( hu ) recombinant ( r ) and interferon (IFN)-gamma *induced* [EGF/TGF-alpha] receptor and TGF-alpha expression by keratinocytes as determined by immunohistochemistry . Positive_regulation EGF TNF 17277048 1747318 In other cell types , receptors *transactivate* the [EGF] receptor , which activates raf-1 kinase . Positive_regulation EGF TNF 1744226 171871 Recombinant significantly *enhanced* [epidermal growth factor receptor (EGF-R)] expression in U373-MG glioma cell line as determined by binding of anti-EGF-R monoclonal antibody ( MAb ) 425 . Positive_regulation EGF TNF 24377382 2883463 Mitogens as , [epidermal growth factor (EGF)] , ( TNF-a ) and fetal bovine serum ( FBS ) *increased* ASMC proliferation ( p < 0.05 , n = 5 ) . Positive_regulation EGF TNF 2482293 122779 In TNF-sensitive ME-180 cervical carcinoma cells , ( 20 ng/ml ) *stimulated* the tyrosine protein kinase activity of the [EGF-receptor (EGF-R)] fivefold when measured by receptor autophosphorylation in an immune complex kinase assay . Positive_regulation EGF TNF 2555361 122017 These results suggest that *induced* modulation of [EGF] receptor occurs through a unique mechanism and may play a role in the cytotoxic actions of TNF . Positive_regulation EGF TNF 3546282 70422 Here we show that human recombinant can *increase* the binding of [epidermal growth factor (EGF)] to these cells . Positive_regulation EGF TNF 3546282 70423 *increased* [EGF] binding with a dose-response relationship similar to that reported earlier for the mitogenic action . Positive_regulation EGF TNF 7905817 245841 IL-1 beta and *increased* the [EGF] receptor surface expression only on BT-20 breast carcinoma cells . Positive_regulation EGF TNS1 15140944 1247165 [EGF] *induces* tyrosine phosphorylation of in MDA-MB-468 cells in a time- and dose dependent manner , but it is independent of an intact actin cytoskeleton or phosphatidylinositol 3-kinase . Positive_regulation EGFR ADRB2 10734107 678721 ( beta ( 2 ) AR ) stimulation of COS-7 cells *induces* [EGFR] dimerization , tyrosine autophosphorylation , and EGFR internalization . Positive_regulation EGFR CAPN8 10644690 661211 [Epidermal growth factor receptor] *activation* of is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway . Positive_regulation EGFR CAPN8 12379276 997172 Src and [epidermal growth factor receptor (EGFR)] stimulated cell motility is *dependent* upon activation . Positive_regulation EGFR CCND1 12612606 1063446 Wnt1 and Wnt5a *induce* expression through [ErbB1] transactivation in HC11 mammary epithelial cells . Positive_regulation EGFR CCND1 12867074 1112049 Certain retinoids , natural and synthetic derivatives of vitamin A , repress cyclin D1 , but activation of the [epidermal growth factor receptor (EGFR)] *induces* . Positive_regulation EGFR CCND1 21821699 2477022 [EGFR] activation increased ES cell proliferation , motility , and invasion and *induced* , matrix metalloproteinase (MMP) 2 , and MMP9 expression . Positive_regulation EGFR CCND1 24499623 2884901 These findings may provide a novel linkage between the [EGFR] and STAT3 signaling pathways and the *activation* of by LMP1 in the carcinogenesis of NPC . Positive_regulation EGFR CLU 19218870 2039565 These results suggest that *requires* [EGFR] activation to deliver its mitogenic signal through the Ras/Raf-1/MEK/ERK signaling cascade in astrocytes . Positive_regulation EGFR CTGF 23929714 2845034 Moreover , endogenous blockade *inhibited* TGF-ß induced [EGFR] activation . Positive_regulation EGFR EDN2 22671705 2626143 Specifically , we establish that the inhibitory effects exerted by endothelins on basal as well as EGF induced expression of the major astroglial glutamate transporter subtype , glutamate transporter 1 , are a direct consequence of the *dependent* retention of the [EGFR] at the cell surface . Positive_regulation EGFR EPHB2 11319218 827098 Membrane proximal signaling is *required* for M-calpain activation downstream of [epidermal growth factor receptor] signaling . Positive_regulation EGFR EPHB2 12447997 1018228 Furthermore , treatment with LPA alone induces the rapid ( maximal signal within 2 min ) tyrosine phosphorylation of [EGFR] , and subsequent ( maximal signal after 5 min ) *activation* of , suggesting that EGFR activation precedes ERK phosphorylation and may constitute a required component for signal relay from the LPA receptor to ERK . Positive_regulation EGFR EPHB2 12447997 1018232 In addition , we find that the LPA regulated tyrosine phosphorylation of [EGFR] and *activation* of are attenuated by batimastat , a generic inhibitor of matrix metalloproteinases (MMP) . Positive_regulation EGFR EPHB2 12891702 1117750 Also , gastrin dependent COX-2 expression did not require PKC activity , *activation* of , or transactivation of [EGFR] . Positive_regulation EGFR EPHB2 14645669 1173050 The kappa opioid agonist ( 5alpha,7alpha,8beta ) - ( - ) -N-methyl-N- ( 7- ( 1-pyrrolidinyl ) -1-oxaspiro ( 4,5 ) dec-8-yl ) benzeneacetamide ( U69,593 ) induced Tyr and Ser phosphorylation of [EGFR] and *activation* of . Positive_regulation EGFR EPHB2 14657000 1202021 We investigated this crosstalk under different conditions and found that both Akt and activation induced by S1P , but not lysophosphatidic acid (LPA) , in HEY ovarian cancer cells *required* PDGFR but not [epidermal growth factor receptor (EGFR)] or insulin-like growth factor-I receptor ( IGFR ) . Positive_regulation EGFR EPHB2 15381832 1298781 The gastric mucosal phospholipid secretory responses to isoproterenol , furthermore , were inhibited by PP2 , a selective *inhibitor* of tyrosine kinase Src responsible for ligand independent [EGFR] phosphorylation , but not by inhibitor , PD98059 . Positive_regulation EGFR EPHB2 15572377 1368344 Here we applied a combination of computational modeling and quantitative experimental studies of the dynamic interactions between [EGFR] and HER2 and their downstream *activation* of to understand this complex signaling system . Positive_regulation EGFR EPHB2 15671645 1350756 We demonstrate a cell based HCS assay to quantify the [epidermal growth factor (EGF) receptor-specific] *activation* of the MAPK . Positive_regulation EGFR EPHB2 15913451 1445701 PGF2alpha induced NOX1 expression was mediated by transactivation of the EGF ( [epidermal growth factor) receptor] and subsequent *activation* of ( extracellular-signal regulated kinase ) 1/2 , PI3K ( phosphoinositide 3-kinase ) and ATF-1 ( activating transcription factor-1 ) , a member of the CREB ( cAMP-response-element binding protein ) /ATF family . Positive_regulation EGFR EPHB2 16630586 1562890 [Epidermal growth factor receptor] *induced* phosphorylation in the suprachiasmatic nucleus . Positive_regulation EGFR EPHB2 16973240 1646997 The effect of leptin on ERK and Na ( + ) , K ( + ) -ATPase was abolished by catalase , specific *inhibitors* of [epidermal growth factor (EGF) receptor] , AG1478 and PD158780 , as well as by inhibitor , PD98059 , and was mimicked by both exogenous H ( 2 ) O ( 2 ) and EGF . Positive_regulation EGFR EPHB2 17686966 1805684 Ciglitazone rapidly activates extracellular signal regulated kinase ( Erk ) MAPK , an event requiring c-Src kinase dependent epidermal growth factor receptor (EGFR) transactivation , whereas troglitazone only weakly activates and does not *induce* [EGFR] transactivation ; Positive_regulation EGFR EPHB2 18033688 1860826 Although we have examined only a few cell lines , our results indicate that the antitumor effects of matuzumab and cetuximab depend on inhibition of [EGFR] downstream signaling *mediated* by Akt or rather than on inhibition of EGFR itself . Positive_regulation EGFR EPHB2 18360054 1887777 Phenylephrine induced protein synthesis , phosphorylation of [EGFR] , and *activation* of in neonatal rat cardiomyocytes were all inhibited by atorvastatin . Positive_regulation EGFR EPHB2 19222789 2100042 In addition , or AKT activation is *essential* for [EGFR] activation because ERK or AKT inhibitor blocks EGFR activation following UVB radiation , indicating that EGFR/AKT/ERK pathways form a regulatory loop and converge into cell cycle progression following UVB radiation . Positive_regulation EGFR EPHB2 19879874 2197166 TK-induced migration was associated with increased phosphorylation of [epidermal growth factor receptor (EGFR)] and extracellular signal regulated kinase ( ERK ) , which was *blocked* by inhibition of protein kinase C ( PKC ) , Src , EGFR and . Positive_regulation EGFR EPHB2 20562913 2308829 These findings negatively correlate with *mediated* threonine phosphorylation of [EGFR] , implicating it as a possible mechanism . Positive_regulation EGFR EPHB2 20956544 2369349 Interestingly , expression of [EGFR] and ß1 integrin protein is more *dependent* on in ECM detached ErbB2 overexpressing cells when compared with ECM attached cells . Positive_regulation EGFR EPHB2 21357683 2415756 Subsequent studies show that JNK2 enhances formation of the EPS8-Abi-1-Sos-1 complex to augment [EGFR] *activation* of Akt and , whereas the absence of JNK2 promotes ESP8/RN-Tre association to inhibit endocytotic trafficking of the EGFR . Positive_regulation EGFR EPHB2 21760527 2456244 We have in the current study compared the effects of Nimotuzumab and Cetuximab on binding of EGF as well as on inhibition of constitutive [EGFR-ErbB2] dimerization and downstream *activation* of . Positive_regulation EGFR EPHB2 22418433 2587973 S2R ( Pgrmc1 ) associates with EGFR and increases [EGFR] levels at the plasma membrane , and the EGFR inhibitors erlotinib and AG1478 , as well as Akt and inhibitors , *suppressed* the NGAL/LCN2 RNA and protein levels . Positive_regulation EGFR EPHB2 22542783 2602899 Globoside promotes *activation* of by interaction with the [epidermal growth factor receptor] . Positive_regulation EGFR EPHB2 23594166 2800049 Albumin induced effects on the [EGF-R] appeared to be mediated through inhibition of ?-secretase activity and were *dependent* on signalling . Positive_regulation EGFR EPHB2 24552586 2919203 This was based upon our finding that the low D2 receptor affinity APD clozapine induced initial down-regulation and delayed [epidermal growth factor receptor] ( EGFR or ErbB1 ) mediated *activation* of the cortical and striatal response in vivo distinct from olanzapine or haloperidol . Positive_regulation EGFR F2R 16525676 1531637 PAR-type thrombin receptors in renal carcinoma cells : mediated [EGFR] *activation* promotes cell migration . Positive_regulation EGFR F2R 16525676 1531638 Here , we show that *mediates* the tyrosine phosphorylation of [EGFR] in human renal carcinoma cells expressing PAR1 and PAR3 endogeneously . Positive_regulation EGFR F2R 16525676 1531639 Our data therefore document a regulatory role of mediated [EGFR] *transactivation* in cancer cell chemotactic migration . Positive_regulation EGFR FAS 12586732 1072109 Stimulation of [EGFR] by EGF *induced* EGFR phosphorylation but no association with or CD95 phosphorylation . Positive_regulation EGFR FAS 15660394 1375905 Hyperosmolarity- and *induced* interactions between CD95 ( Fas/APO-1 ) and the [epidermal growth factor receptor (EGFR)] involve EGFR catalyzed CD95 tyrosine phosphorylation . Positive_regulation EGFR FAS 15660394 1375914 CD95 mutants with tyrosine-phenylalanine exchanges at positions 232 and 291 failed to translocate to the plasma membrane and to recruit Fas associated death domain and caspase 8 , although these mutants still associated with the [EGFR] in the cytosol in *response* to hyperosmolarity and . Positive_regulation EGFR FAS 17195092 1702145 FRET-studies in mouse embryonic fibroblasts , which in contrast to Huh7 express endogenous CD95 , revealed that EGF , but not *induced* [EGFR-homomerization] , whereas CD95 ligand , but not EGF resulted in EGFR/CD95-heteromerization . Positive_regulation EGFR FAS 18471522 1910393 In quiescent HSCs , *led* to a rapid phosphorylation of the [epidermal growth factor receptor (EGFR)] , extracellular signal regulated kinase ( Erk ) , and c-Src , but not of c-Jun-N-terminal kinase and p47(phox) , an activating subunit of reduced nicotinamide adenine dinucleotide phosphate oxidase . Positive_regulation EGFR FAS 18471522 1910395 *induced* [EGFR] and Erk phosphorylation were abolished after proteinase inhibition by GM6001 and in the presence of neutralizing epidermal growth factor antibodies , suggestive of a ligand dependent EGFR phosphorylation in response to CD95L . Positive_regulation EGFR FAS 19141676 2025741 No significant genetic interactions were detected with the Notch , Wingless , Hedgehog or Dpp pathways , nor did Fas2 inhibit the FGF receptor or Torso , indicating specificity in the inhibitory *role* of in [EGFR] signalling . Positive_regulation EGFR FLG 22796440 2645584 Reduced expression of [epidermal growth factor receptor] , E-cadherin , and occludin in the skin of flaky tail mice is *due* to and loricrin deficiencies . Positive_regulation EGFR FLG 22796440 2645589 Our findings suggest that the observed reductions in [EGFR] , E-cadherin , and occludin expression were *due* to deficiency accompanied with subsequent loricrin deficiency and disruption of the SIRT1 pathway in the skin of Flg ( ft ) mice . Positive_regulation EGFR FOXO1 17536007 1773145 However , AREG mediated phosphorylation of PKB and *required* both [EGFR] and SFK activation . Positive_regulation EGFR GPR115 16543233 1555412 It has been reported that activation *induces* [epidermal growth factor (EGF) receptor] ( EGFR ) transactivation through the shedding of heparin binding EGF-like growth factor ( HB-EGF ) . Positive_regulation EGFR GPR115 16780214 1573344 In this signaling process stimulation *induces* phosphorylation of the [EGFR] , combining the broad diversity of GPCRs with the potent signaling capacities of this receptor tyrosine kinase . Positive_regulation EGFR GPR115 18658095 2010790 ERK1/2 mediate wounding- and ligands *induced* [EGFR] activation via regulating ADAM17 and HB-EGF shedding . Positive_regulation EGFR GPR115 18991757 1989895 Therapeutic targeting of mediated [epidermal growth factor receptor] *transactivation* in human glioma brain tumors . Positive_regulation EGFR GPR115 19342448 2094184 Coordinate regulation of estrogen mediated fibronectin matrix assembly and [epidermal growth factor receptor] *transactivation* by the , GPR30 . Positive_regulation EGFR GPR132 16543233 1555401 It has been reported that activation *induces* [epidermal growth factor (EGF) receptor] ( EGFR ) transactivation through the shedding of heparin binding EGF-like growth factor ( HB-EGF ) . Positive_regulation EGFR GPR132 16780214 1573333 In this signaling process stimulation *induces* phosphorylation of the [EGFR] , combining the broad diversity of GPCRs with the potent signaling capacities of this receptor tyrosine kinase . Positive_regulation EGFR GPR132 18658095 2010779 ERK1/2 mediate wounding- and ligands *induced* [EGFR] activation via regulating ADAM17 and HB-EGF shedding . Positive_regulation EGFR GPR132 18991757 1989884 Therapeutic targeting of mediated [epidermal growth factor receptor] *transactivation* in human glioma brain tumors . Positive_regulation EGFR GPR132 19342448 2094173 Coordinate regulation of estrogen mediated fibronectin matrix assembly and [epidermal growth factor receptor] *transactivation* by the , GPR30 . Positive_regulation EGFR GPR87 16543233 1555481 It has been reported that activation *induces* [epidermal growth factor (EGF) receptor] ( EGFR ) transactivation through the shedding of heparin binding EGF-like growth factor ( HB-EGF ) . Positive_regulation EGFR GPR87 16780214 1573413 In this signaling process stimulation *induces* phosphorylation of the [EGFR] , combining the broad diversity of GPCRs with the potent signaling capacities of this receptor tyrosine kinase . Positive_regulation EGFR GPR87 18658095 2010859 ERK1/2 mediate wounding- and ligands *induced* [EGFR] activation via regulating ADAM17 and HB-EGF shedding . Positive_regulation EGFR GPR87 18991757 1989964 Therapeutic targeting of mediated [epidermal growth factor receptor] *transactivation* in human glioma brain tumors . Positive_regulation EGFR GPR87 19342448 2094254 Coordinate regulation of estrogen mediated fibronectin matrix assembly and [epidermal growth factor receptor] *transactivation* by the , GPR30 . Positive_regulation EGFR HBEGF 10187826 602962 These results demonstrate that keratinocyte contact with type I collagen is sufficient to induce collagenase-1 expression , whereas sustained enzyme production requires autocrine [EGFR] *activation* by as an obligatory intermediate step , thereby maintaining collagenase-1 dependent migration during the re-epithelialization of epidermal wounds . Positive_regulation EGFR HBEGF 10903991 713460 Heparin blockade of thrombin induced smooth muscle cell migration involves inhibition of [epidermal growth factor (EGF) receptor] *transactivation* by . Positive_regulation EGFR HBEGF 10903991 713461 Because thrombin stimulation of vascular smooth muscle cell migration is blocked by heparin and because heparin can displace HB-EGF , we investigated the possibility that thrombin stimulation of smooth muscle cells ( SMCs ) depends on [EGFR] *activation* by . Positive_regulation EGFR HBEGF 10903991 713462 We conclude from these data that the inhibitory effect of heparin on SMC migration induced by thrombin relies , at least in part , on a blockade of mediated [EGFR] *transactivation* . Positive_regulation EGFR HBEGF 11139469 770080 Thus , Ang II is involved in the VEGF-Ang-Tie2 system via mediated [EGFR] *transactivation* , and this link should be considerable in pathological conditions in which collateral blood flow is required . Positive_regulation EGFR HBEGF 11181057 785014 Among four EGF-receptor (EGFR) family members , the [EGFR] was solely *activated* by EGF , , transforming growth factor alpha ( TGF alpha ) , epiregulin (ER) , and betacellulin (BTC) , resulting in induction of phenotypic modulation of SMCs . Positive_regulation EGFR HBEGF 11795306 892300 Studies from our laboratory as well as two other groups have demonstrated that [EGFR] transactivation by different GPCR agonists and in different cell types , including SMCs , is *mediated* by ( HB-EGF ) . Positive_regulation EGFR HBEGF 11795306 892301 *dependent* [EGFR] activation is blocked by heparin , a growth inhibitor of SMCs in vitro and in vivo . Positive_regulation EGFR HBEGF 11971193 933616 They also overexpressed CD9 , a tetraspanin that binds to the heparin binding domain of HB-EGF and is critical for promoting [ErbB1] *activation* by . Positive_regulation EGFR HBEGF 12481249 1032721 [ErbB1] and ErbB2 receptors were *activated* by . Positive_regulation EGFR HBEGF 12773386 1094951 These results suggest that cardiac valvulogenesis is dependent on [EGFR] *activation* by TACE derived soluble , and that EGFR signaling is required to regulate bone morphogenetic protein signaling in this context . Positive_regulation EGFR HBEGF 12853287 1149769 To test a functional role for HB-EGF in ET-1 signaling , we showed that exogenous *stimulated* phosphorylation of [ErbB1] and growth of mesangial cells . Positive_regulation EGFR HBEGF 14647423 1201896 Moreover , we report that the [EGFR] transactivation signal *involves* the EGFR ligands amphiregulin , and TGFalpha as well as the metalloproteinases ADAM 10 , 15 and 17 , depending on the cellular system . Positive_regulation EGFR HBEGF 15143154 1273156 Consistent with its agonist action , stimulation of these cells *caused* marked phosphorylation of the [EGF-R] and its adapter molecule , Shc , as well as ERK1/2 and its dependent protein , p90 ribosomal S6 kinase , in a manner similar to that elicited by Ang II or EGF . Positive_regulation EGFR HBEGF 15557365 1343396 These novel findings suggest that the mechanism of pressure induced MT involves metalloproteinases 2/9 activation with subsequent release and [EGFR] *transactivation* . Positive_regulation EGFR HBEGF 16153425 1455322 Plasmin can also activate metalloproteinases on the cell surface , which can release the tethered ligand heparin binding epidermal growth factor ( ) , which can in turn *activate* the [epidermal growth factor receptor (EGFR)] . Positive_regulation EGFR HBEGF 16177113 1457996 All of these inhibitors completely blocked LL-37 induced keratinocyte migration , which indicates that migration occurs via mediated [EGFR] *transactivation* . Positive_regulation EGFR HBEGF 16261333 1539277 Our data suggest that ROS mediated oxidation of SHP-2 is essential for mediated [EGFR] *transactivation* in ET-1 signaling pathway in NRK-52E cells . Positive_regulation EGFR HBEGF 16336626 1503743 Phe induced phosphorylation of the [EGF-R] , and subsequently of Shc and ERK1/2 , was *attenuated* by inhibition of MMP or with the selective inhibitor , CRM197 , or by a neutralizing antibody . Positive_regulation EGFR HBEGF 16391241 1533463 Our data suggest that ET-1-ETA mediated ROS generation can transiently inhibit SHP-2 activity to facilitate the MMP dependent and *stimulated* [EGFR] transactivation and mitogenic signal transduction in rat cardiac fibroblasts . Positive_regulation EGFR HBEGF 16443372 1540540 Subchronic *stimulation* of [ErbB1] with transforming growth factor alpha ( TGFalpha ) , EGF , or down-regulated protein expression of the GluR1 AMPA receptor subunit in cultured neocortical neurons . Positive_regulation EGFR HBEGF 16641152 1563001 In summary , this is the first demonstration that shedding dependent [EGFR] *transactivation* , along with activation of TGF-beta signaling pathways , mediates Ang II-induced renal tubular epithelial cell hypertrophy . Positive_regulation EGFR HBEGF 17001310 1716324 Induction of HB-EGF expression and ectodomain shedding synergistically led to robust epidermal growth factor receptor (EGFR) phosphorylation , whereas inhibition of expression by use of the HB-EGF inhibitor ( CRM197 ) or siRNA *resulted* in the suppression of chemotherapy induced [EGFR] phosphorylation . Positive_regulation EGFR HBEGF 17001310 1716325 These results suggest that the chemotherapy induced [EGFR] activation is *regulated* by . Positive_regulation EGFR HBEGF 17092291 1685176 The [EGFR] was either *activated* by ( 1 nM ) or inhibited with the specific EGFR inhibitor gefitinib ( 1 or 5 microM ) . Positive_regulation EGFR HBEGF 17284517 1698255 Taken together , our data suggest that ATP , released upon epithelial injury , acts as an early signal to trigger cell responses including an increase in shedding , subsequent [EGFR] *transactivation* and its downstream signaling , resulting in wound healing . Positive_regulation EGFR HBEGF 17360433 1712708 HT-H cells expressed ErbB family receptors and bound EGF and ( HB-EGF ) , but [ErbB] family receptor phosphorylation in these cells *required* GWRQ . Positive_regulation EGFR HBEGF 17361012 1777671 Epidermal growth factor receptor (EGFR) ligands ( transforming growth factor alpha ( TGFalpha ) , and epiregulin ) are constitutively *induced* by LMP1 , leading to [EGFR] phosphorylation but also down-regulation , degradation or turn-over , with the appearance of cleaved EGFR fragments . Positive_regulation EGFR HBEGF 17717322 1848770 Our data , for the first time , showed that IL-13 plays an important role in epithelial repair , and that its effect is mediated through the autocrine release of and *activation* of [EGFR] . Positive_regulation EGFR HBEGF 17848576 1817809 Juxtacrine *activation* of [epidermal growth factor (EGF) receptor] by membrane anchored protects epithelial cells from anoikis while maintaining an epithelial phenotype . Positive_regulation EGFR HBEGF 17855771 1818204 Therefore , we hypothesize that juxtacrine *activation* of [EGFR] by membrane anchored may play an important role in the regulation of tight junction proteins and TER . Positive_regulation EGFR HBEGF 17909029 1803536 RNA silencing indicated that PIKfyve is a mediator of *stimulated* EGFR nuclear trafficking , [EGFR] binding to the cyclin D1 promoter , and cell cycle progression . Positive_regulation EGFR HBEGF 18658095 2011037 Taken together , our data suggest that in addition to functioning as an EGFR downstream effector , ERK1/2 also mediates ADAM dependent shedding and subsequent [EGFR] *transactivation* in response to a variety of stimuli , including wounding and GPCR ligands . Positive_regulation EGFR HBEGF 18986098 1983744 The authors conclude that leptin stimulates OAC proliferation via increased gene expression of HB-EGF and TGFalpha , MMP mediated extracellular release of and TGFalpha and subsequent *activation* of [EGFR] . Positive_regulation EGFR HBEGF 19027738 1998397 The anti-EGFR monoclonal antibody blocks cisplatin induced activation of [EGFR] signaling *mediated* by . Positive_regulation EGFR HBEGF 19225541 2100066 In summary , rapid HA accumulation after epidermal wounding occurs through a mechanism requiring cleavage of and *activation* of [EGFR] signaling . Positive_regulation EGFR HBEGF 19559571 2110498 *induced* phosphorylation of [EGFR] with maximum phosphorylation at 1h . Positive_regulation EGFR HBEGF 19879874 2197168 This study demonstrates a novel role of TK in skin wound healing and uncovers new signaling pathways mediated by TK in promoting keratinocyte migration through activation of the PAR(1)-PKC-Src-MMP pathway and shedding dependent [EGFR] *transactivation* . Positive_regulation EGFR HBEGF 20139904 2208093 The epoxyeicosatrienoic acid stimulated phosphorylation of [EGF-R] *involves* the activation of metalloproteinases and the release of in cancer cells . Positive_regulation EGFR HBEGF 20152812 2220360 We conclude that the inhibition of *mediated* [EGFR] activation is one of the alternative mechanisms for the antihypertrophic action of adiponectin . Positive_regulation EGFR HBEGF 20208558 2259489 Activation of [EGFR] by proteasome inhibition *requires* in pancreatic cancer cells . Positive_regulation EGFR HBEGF 20732323 2323987 GPR48 Induced keratinocyte proliferation occurs through *mediated* [EGFR] transactivation . Positive_regulation EGFR HBEGF 20934403 2347604 nuclear translocation and [EGFR] *transactivation* from proHB-EGF shedding mediated by ADAM17 activated by TGFß might be an important pathway of gastric cancer cell proliferation by TGFß . Positive_regulation EGFR HBEGF 21289053 2410020 release *mediates* glucose induced activation of the [epidermal growth factor receptor] in mesangial cells . Positive_regulation EGFR HBEGF 21289053 2410021 However , general metalloprotease inhibition , as well as specific inhibitors of ( HB-EGF ) , *prevented* both [EGFR] and downstream Akt activation . Positive_regulation EGFR HBEGF 21289053 2410031 Thus , HG-induced [EGFR] transactivation in MC is *mediated* by the release of , which requires activity of the metalloprotease ADAM17 . Positive_regulation EGFR HBEGF 21552904 345725 It ( a ) blocks the binding of EGF , TGF alpha and HB-EGF to the EGFR , ( b ) prevents the EGF , TGF alpha and *induced* tyrosine phosphorylation of the [EGFR] , and ( c ) inhibits the growth in vitro of the head and neck tumour ( HN5 ) cell line overexpressing the EGF receptor . Positive_regulation EGFR HBEGF 21946538 2492538 induction *increases* phosphorylation of the [epidermal growth factor receptor] ( EGFR , also known as ErbB1 ) in mice with RPGN . Positive_regulation EGFR HBEGF 22510844 2686561 [EGFR] expression was inhibited by stable short-hairpin RNA transfection or by the kinase inhibitor erlotinib , and it was *activated* by heparin binding epidermal growth factor-like growth factor ( ) . Positive_regulation EGFR HBEGF 23451083 2749370 And soluble *activates* [EGFR] . Positive_regulation EGFR HBEGF 24303948 2916777 *increased* the expressions of [phospho-EGFR] and ErbB4 receptors , the phosphorylation of extracellular signal regulated kinase ( ERK ) and Akt . Positive_regulation EGFR HBEGF 24563483 2929195 Down-regulation of HS6ST-1 or HS6ST-2 in human ovarian cancer cell lines results in 30-50 % reduction in glucosamine 6-O-sulfate levels in HS , impairing *dependent* [EGFR] signaling and diminishing FGF2 , IL-6 , and IL-8 mRNA and protein levels in cancer cells . Positive_regulation EGFR HBEGF 8621250 354161 Our findings suggest that is relatively abundant in human gastric cancers and that co-expression of the EGF ligand family may *lead* to excessive activation of [EGF-R] in this disorder . Positive_regulation EGFR HBEGF 9041204 415983 Thus , [EGFR] activation in SUM-102PT cells is *mediated* , at least in part , by autocrine/juxtacrine stimulation by . Positive_regulation EGFR HBEGF 9041204 415984 Thus , SUM-102PT is a new human breast cancer cell line that expresses activated [EGFR] as a *result* of an autocrine/juxtacrine interaction with which , in turn , results in activation of STAT-3 . Positive_regulation EGFR HBEGF 9110152 425017 Amphiregulin (AR) and ( HB-EGF ) bind and *activate* the [EGFR] while Heregulin (HRG) acts through the p185erbB-2 and p180erbB-4 tyrosine kinases . Positive_regulation EGFR ID1 14688027 1218834 In contrast , down-regulation of in androgen independent DU145 cells by its antisense oligonucleotides *resulted* in suppression of [EGF-R] expression at both transcriptional and protein levels . Positive_regulation EGFR ID1 21606196 2445806 Here we show that is *induced* by nicotinic acetylcholine receptor ( nAChR ) and [epidermal growth factor receptor (EGFR)] signaling in a panel of NSCLC cell lines and primary cells from the lung . Positive_regulation EGFR IFI27 17317676 1711629 Nevertheless , erlotinib inhibited [p-EGFR] in HNSCC tumors , which appeared associated to clinical benefit , and *induced* in biopsies of normal skin . Positive_regulation EGFR IFI27 18575749 1930260 These results suggest that E-cadherin mediated adhesion may be involved in the contact stimulation for cell proliferation in part through the downregulation of and the *activation* of [EGFR] in human cancers . Positive_regulation EGFR IL1B 11179516 784768 *activated* [epidermal growth factor (EGF) receptor] in cultured human keratinocytes in a time- and dose dependent manner . Positive_regulation EGFR LAMB3 16460839 1548019 Underneath invading tumor cells anti-laminin 5 staining is diminished , and degradation products can *stimulate* cell migration and [epidermal growth factor (EGF) receptor] signaling . Positive_regulation EGFR MAP2K6 11098053 786422 By contrast , activity *required* [EGFR] activation and , as shown by use of the MEK inhibitor PD98059 and a dominant negative MEK construct , was necessary for Bcl-x ( L ) expression and survival . Positive_regulation EGFR MAP2K6 16432158 1516234 We conclude that SOCS-1 methylation status can differentially affect STAT3 *activation* by IL-6R and [EGFR] through JAK or in different HNSCC and response to pharmacologic antagonists . Positive_regulation EGFR MAP2K6 21630605 2437052 The skin toxicity profile of [EGFR] *inhibitors* , en Raf inhibitors , mTOR inhibitors , VEGF targeting molecules , multikinase inhibitors , the HER2 monoclonal antibody trastuzumab and the CTLA-4 monoclonal antibodies are discussed . Positive_regulation EGFR MAP2K6 8662819 367335 *Role* of in regulation of the [epidermal growth factor receptor] by protein kinase C . Positive_regulation EGFR MMP28 12421825 1036437 Targeting of only the E domain of ERalpha to the plasma membrane resulted in activation and [EGFR] *transactivation* . Positive_regulation EGFR MMP28 14656925 1188477 Focusing on alpha ( 1b ) -adrenoceptors , we suggest here that *dependent* activation of the [EGFR] promotes vasoconstriction as well as growth . Positive_regulation EGFR MMP28 14720519 1197869 On the other hand , we also found that *mediated* activation of [EGFR] can occur in an autocrine manner in cells which secrete uPA . Positive_regulation EGFR MMP28 15277330 1277126 inhibitors ( batimastat and Ro28-2653 ) and the blocking antibodies anti-MMP-2 and anti-membrane type 1-MMP inhibited the oxLDL induced sphingomyelin/ceramide pathway activation and subsequent activation of ERK1/2 and DNA synthesis but did not *inhibit* the oxLDL induced [epidermal growth factor receptor] and platelet derived growth factor receptor activation . Positive_regulation EGFR MMP28 15963982 1446063 Our results suggest that the *dependent* [EGFR] activation observed in V14 RhoA cells represents the starting point of a signaling route that promotes cell motility by activation of ERK1 ,2 and further enhancement of proteases production . Positive_regulation EGFR MMP28 16153425 1455328 [EGFR] phosphorylation by plasmin was *blocked* by inhibition of activity and the ligand HB-EGF . Positive_regulation EGFR MMP28 16289596 1546837 In these experiments we used an [EGFR] *inhibitor* , AG1478 or inhibitor , GM6001 . Positive_regulation EGFR MMP28 16336626 1503742 Phe induced phosphorylation of the [EGF-R] , and subsequently of Shc and ERK1/2 , was *attenuated* by inhibition of or HB-EGF with the selective inhibitor , CRM197 , or by a neutralizing antibody . Positive_regulation EGFR MMP28 17113976 1651202 Consistent with this , inhibition of matrix metalloproteinases ( MMPs ) with GM6001 reduced ERK1/2 activation by ET-1 , consistent with partial involvement of the *dependent* [EGF-R] activation in this cascade . Positive_regulation EGFR MMP28 17113976 1651271 These data demonstrate that ET-1 causes ERK/RSK-1/CREB phosphorylation predominantly through activation of G ( i ) and Src , with a minor contribution from dependent [EGF-R] *transactivation* . Positive_regulation EGFR MMP28 18656632 1942638 [EGFR] phosphorylation by insulin was *blocked* by inhibition of activity and the ligand HB-EGF . Positive_regulation EGFR MMP28 19225051 2061710 Taken together , these results indicate that osmotic stress induces *dependent* activation of [EGFR] , likely via shedding of TGF-alpha , and downstream activation of Ras and the MAP kinases p38 and ERK1/2 , which stimulate TonEBP transactivation activity . Positive_regulation EGFR MMP28 19394555 2070225 [EGFR] phosphorylation by ATF was *blocked* by inhibition of activity and the ligand HB-EGF . Positive_regulation EGFR MMP28 20110336 2265078 We hypothesized that excessive stimulation of GPCRs such as alpha ( 1 ) -adrenergic receptors activates *dependent* [EGFR] transactivation and contributes to the development of hypertension by promoting increased synthesis of contractile proteins in vascular smooth muscle ( VSM ) . Positive_regulation EGFR MMP28 20889674 2353426 To explore the EGFR signaling pathway , we used a broad-spectrum inhibitor , GM-6001 , two selective [EGFR] tyrosine kinase *inhibitors* , AG-1478 and PD-153035 , an HB-EGF neutralizing antibody , and a specific small interfering RNA ( siRNA ) against the EGFR . Positive_regulation EGFR MMP28 21460200 2433244 Thus mediated [EGFR] *activation* appears essential to cardiac protection and signaling via A ( 1 ) ARs and preconditioning . Positive_regulation EGFR MMP28 22792188 2628400 This study reports for the first time that Egr-1 induction by IL-1beta involves EGFR and *dependent* [EGFR] phosphorylation . Positive_regulation EGFR MMP28 23896774 2367240 *induced* EGFR proligand cleavage and ligand binding to [EGFR] seem to be involved in this pathway . Positive_regulation EGFR MMP7 12421825 1036452 Targeting of only the E domain of ERalpha to the plasma membrane resulted in activation and [EGFR] *transactivation* . Positive_regulation EGFR MMP7 14656925 1188492 Focusing on alpha ( 1b ) -adrenoceptors , we suggest here that dependent *activation* of the [EGFR] promotes vasoconstriction as well as growth . Positive_regulation EGFR MMP7 14720519 1197884 On the other hand , we also found that *mediated* activation of [EGFR] can occur in an autocrine manner in cells which secrete uPA . Positive_regulation EGFR MMP7 15277330 1277141 inhibitors ( batimastat and Ro28-2653 ) and the blocking antibodies anti-MMP-2 and anti-membrane type 1-MMP inhibited the oxLDL induced sphingomyelin/ceramide pathway activation and subsequent activation of ERK1/2 and DNA synthesis but did not *inhibit* the oxLDL induced [epidermal growth factor receptor] and platelet derived growth factor receptor activation . Positive_regulation EGFR MMP7 15623600 1349048 *activates* the [epidermal growth factor (EGF) receptor] by releasing an EGF ligand , tumor growth factor ( TGF ) -alpha . Positive_regulation EGFR MMP7 15963982 1446078 Our results suggest that the dependent [EGFR] *activation* observed in V14 RhoA cells represents the starting point of a signaling route that promotes cell motility by activation of ERK1 ,2 and further enhancement of proteases production . Positive_regulation EGFR MMP7 16153425 1455343 [EGFR] phosphorylation by plasmin was *blocked* by inhibition of activity and the ligand HB-EGF . Positive_regulation EGFR MMP7 16289596 1546852 In these experiments we used an [EGFR] *inhibitor* , AG1478 or inhibitor , GM6001 . Positive_regulation EGFR MMP7 16336626 1503758 Phe induced phosphorylation of the [EGF-R] , and subsequently of Shc and ERK1/2 , was *attenuated* by inhibition of or HB-EGF with the selective inhibitor , CRM197 , or by a neutralizing antibody . Positive_regulation EGFR MMP7 17113976 1651217 Consistent with this , inhibition of matrix metalloproteinases ( MMPs ) with GM6001 reduced ERK1/2 activation by ET-1 , consistent with partial involvement of the dependent [EGF-R] *activation* in this cascade . Positive_regulation EGFR MMP7 17113976 1651286 These data demonstrate that ET-1 causes ERK/RSK-1/CREB phosphorylation predominantly through activation of G ( i ) and Src , with a minor contribution from *dependent* [EGF-R] transactivation . Positive_regulation EGFR MMP7 18656632 1942653 [EGFR] phosphorylation by insulin was *blocked* by inhibition of activity and the ligand HB-EGF . Positive_regulation EGFR MMP7 19225051 2061725 Taken together , these results indicate that osmotic stress induces *dependent* activation of [EGFR] , likely via shedding of TGF-alpha , and downstream activation of Ras and the MAP kinases p38 and ERK1/2 , which stimulate TonEBP transactivation activity . Positive_regulation EGFR MMP7 19394555 2070240 [EGFR] phosphorylation by ATF was *blocked* by inhibition of activity and the ligand HB-EGF . Positive_regulation EGFR MMP7 20110336 2265093 We hypothesized that excessive stimulation of GPCRs such as alpha ( 1 ) -adrenergic receptors activates dependent [EGFR] *transactivation* and contributes to the development of hypertension by promoting increased synthesis of contractile proteins in vascular smooth muscle ( VSM ) . Positive_regulation EGFR MMP7 20889674 2353441 To explore the EGFR signaling pathway , we used a broad-spectrum inhibitor , GM-6001 , two selective [EGFR] tyrosine kinase *inhibitors* , AG-1478 and PD-153035 , an HB-EGF neutralizing antibody , and a specific small interfering RNA ( siRNA ) against the EGFR . Positive_regulation EGFR MMP7 21460200 2433259 Thus mediated [EGFR] *activation* appears essential to cardiac protection and signaling via A ( 1 ) ARs and preconditioning . Positive_regulation EGFR MMP7 22792188 2628437 This study reports for the first time that Egr-1 induction by IL-1beta involves EGFR and *dependent* [EGFR] phosphorylation . Positive_regulation EGFR MMP7 23896774 2367255 *induced* EGFR proligand cleavage and ligand binding to [EGFR] seem to be involved in this pathway . Positive_regulation EGFR MUC16 15121636 1266519 We hypothesize that TNF-alpha converting enzyme (TACE) is activated by cigarette smoke , resulting in increased shedding of EGFR proligand , leading to [EGFR] phosphorylation and *induction* in human airway epithelial ( NCI-H292 ) cells . Positive_regulation EGFR MUC16 20724237 2317961 In this investigation , we demonstrate that NE-induced production *requires* reactive oxygen species ( ROS ) production , which activates TACE , resulting in TGF-a shedding , and [EGFR] phosphorylation in NCI-H292 epithelial cells . Positive_regulation EGFR NGFR 20566383 2290325 K252a , the inhibitor , *inhibits* fMLP or EGF associated ROS production , CD11b expression and EGF induced [EGFR] phosphorylation ; Positive_regulation EGFR NT5E 23086814 2690452 Potential prognostic biomarker *regulates* [epidermal growth factor receptor] expression in human breast cancer . Positive_regulation EGFR NT5E 23086814 2690455 We also showed that *regulates* [EGFR] phosphorylation by Src ( P < 0.01 ) . Positive_regulation EGFR PLAT 17452424 1778057 Firstly , we found that *induced* a rapid and transient phosphorylation of the [EGFR] . Positive_regulation EGFR PLAU 14704150 1219034 Osteopontin *induces* AP-1 mediated secretion of through c-Src dependent [epidermal growth factor receptor] transactivation in breast cancer cells . Positive_regulation EGFR PLAU 15816844 1393287 As a result , *dependent* focal adhesion kinase ( FAK ) and integrin mediated [EGFR] signaling are suppressed . Positive_regulation EGFR PLAU 15816844 1393289 however , GM3 inhibits uPA induced EGFR phosphorylation by blocking the crosstalk between integrin and EGFR , whereas GT1b suppresses both *induced* FAK and [EGFR] activation by preventing the activation of integrin alpha(5)beta ( 1 ) . Positive_regulation EGFR PLAU 15874933 1405687 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and [epidermal growth factor receptor (EGFR)] in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Positive_regulation EGFR PLAU 15874933 1405745 *induced* time dependent phosphorylation of [EGFR] , which was dependent on plasmin activity . Positive_regulation EGFR PLAU 17634529 1770486 In 4910 EGFR overexpressing cells , down-regulation of uPAR and *induced* the down-regulation of [EGFR] and vascular endothelial growth factor and inhibited angiogenesis in both in vitro and in vivo angiogenic assays . Positive_regulation EGFR RGS16 11602604 888192 co-immunoprecipitated with EGFR , and the interaction did not *require* [EGFR] activation . Positive_regulation EGFR S100A7 23535840 2772544 Further signaling studies revealed that *enhances* EGF induced [EGFR] phosphorylation and actin remodeling that seems to favor lamellipodia formation in ERa ( - ) cells . Positive_regulation EGFR TNF 10023672 590679 Prior to the onset of apoptosis , *caused* a significant reduction in the level of [EGFr] tyrosine phosphorylation in Sen cells but mediated only limited suppression of EGFr tyrosine phosphorylation in apoptotically resistant Res cells . Positive_regulation EGFR TNF 10077640 595363 [EGF-R] gene expression was *stimulated* further by . Positive_regulation EGFR TNF 11337489 827572 We also have shown that *induces* tyrosine phosphorylation and internalization of the overexpressed EGFR in NIH3T3 cells and the endogenously expressed [EGFR] in A431 cells and that the transactivation by TNF is suppressed by N-acetyl-l-cysteine or overexpression of an endogenous reducing molecule , thioredoxin , but not by phosphatidylinositol 3-kinase inhibitors and protein kinase C inhibitor . Positive_regulation EGFR TNF 11337489 827577 Taken together , this evidence strongly suggests that [EGFR] *transactivation* by , which is regulated in a redox dependent manner , is playing a pivotal role in TNF induced NF-kappa B activation . Positive_regulation EGFR TNF 12469217 1032571 Also , did not *induce* [EGFR] expression at the protein level . Positive_regulation EGFR TNF 15841081 1403988 Furthermore , the TNF-alpha induced responses except for NF-kappaB activation were blocked by metalloprotease inhibitors , suggesting that gefitinib inhibited the transactivation of [EGFR] *induced* by . Positive_regulation EGFR TNF 16427093 1554296 In addition , *stimulated* tyrosine phosphorylation of the [EGFR] within 5 min after stimulation . Positive_regulation EGFR TNF 16441427 1516820 We have shown that the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib ( ` Iressa ' , ZD1839 ) inhibits the development of intrahepatic metastases of hepatocellular carcinoma CBO140C12 , and [EGFR] *transactivation* by is a possible target of gefitinib . Positive_regulation EGFR TNF 17148666 1661544 In primary cultures of human gallbladder epithelial cells , *induced* [EGF-R] overexpression . Positive_regulation EGFR TNF 1744226 171872 Cultured fibroblasts showed no *upregulation* of [EGF-R] by , suggesting a differential effect of TNF-alpha on EGF-R expression on glioma cells and normal cells . Positive_regulation EGFR TNF 18364436 1912763 We , for the first time , demonstrate that binding of staphylococcal enterotoxin B to MHC-II results in activation of TNF-alpha converting enzyme , [epidermal growth factor receptor] , p38MAPK , and NF-kappaB *inducing* biphasic production . Positive_regulation EGFR TNF 18701712 1950524 *stimulated* [EGFR] phosphorylation in young adult mouse colon epithelial cells , and loss of EGFR expression or inhibition of kinase activity increased TNF induced apoptosis , which was prevented in WT but not by kinase-inactive EGFR expression . Positive_regulation EGFR TNF 22301110 2580340 *induces* upregulation of [EGFR] expression and signaling in human colonic myofibroblasts . Positive_regulation EGFR TNF 22301110 2580341 also *increased* [EGFR] expression and signaling in primary myofibroblasts isolated from human colon tissue . Positive_regulation EGFR TNF 22301110 2580342 *induced* upregulation of [EGFR] may be a plausible mechanism to explain the exaggerated cellular responsiveness that characterizes inflammatory bowel disease and that may contribute to a microenvironment that predisposes to colitis associated cancer through enhanced COX-2 expression . Positive_regulation EGFR TNF 23108309 2691115 *triggered* AR shedding and [EGFR] transactivation in HCC cells . Positive_regulation EGFR TNF 23108309 2691120 AR release and [EGFR] *transactivation* by constitutes a novel link between inflammatory signals and pro-tumorigenic mechanisms in liver cells . Positive_regulation EGFR TNF 23389627 2759166 In this study we explore the mechanisms underlying *induced* [EGFR] activation . Positive_regulation EGFR TNF 23822636 2849343 We have recently identified *induced* phosphorylation of [epidermal growth factor receptor (EGFR)] at Thr-669 and Ser-1046/1047 via ERK and p38 pathways , respectively . Positive_regulation EGFR TNF 2482293 122781 The results suggest that *increased* [EGF-R] tyrosine protein kinase activity and the state of EGF-receptor tyrosine phosphorylation in a manner similar to that reported for EGF . Positive_regulation EGFR TNF 9162524 389376 *Activation* of [epidermal growth factor receptor] tyrosine phosphorylation by correlates with loss of cytotoxic activity . Positive_regulation EGFR TNFSF10 22456178 2691304 *activated* [EGFR] by Cbl-b regulated EGFR redistribution in lipid rafts antagonises TRAIL induced apoptosis in gastric cancer cells . Positive_regulation EGFR TNFSF10 22456178 2691309 However , knockdown of Cbl-b also enhanced EGFR translocation into lipid rafts and [EGFR] pathway activation *induced* by . Positive_regulation EGFR TNFSF10 22456178 2691310 Taken together , *induced* [EGFR] activation through Cbl-b regulated EGFR redistribution in lipid rafts antagonised TRAIL induced apoptosis . Positive_regulation EGLN1 SLC6A2 23400226 2755106 The six-coordinate complexes [ ReO ( L1 ) ( Ph2btu ) ] ( 12 ) , where HPh2btu is N , N-diphenyl-N'-benzoylthiourea , can be obtained by treatment of [ ReOCl ( L1 ) ] with [HPh2btu] in the *presence* of . Positive_regulation EGLN3 EPAS1 15156561 1250497 We further tested the regulation of these genes by HIF-1 and HIF-2 and found that siRNA targeted degradation of HIF-1alpha and *results* in decreased hypoxia induced [PHD3] expression . Positive_regulation EGLN3 HEXIM1 24015760 2862382 The up-regulation of hydroxylation involves *mediated* induction of PHD3 ( prolyl hydroxylase 3 ) expression and interaction of [PHD3] with HIF-1a . Positive_regulation EGLN3 HIF1A 15104534 1272934 In the human osteosarcoma cell line , U2OS , selective suppression of expression by RNA interference resulted in a complete *loss* of hypoxic induction of PHD2 and [PHD3] . Positive_regulation EGLN3 HIF1A 15156561 1250498 We further tested the regulation of these genes by HIF-1 and HIF-2 and found that siRNA targeted degradation of and HIF-2alpha *results* in decreased hypoxia induced [PHD3] expression . Positive_regulation EGLN3 IFNG 19574556 2122218 and , to a lesser extent , IFNalpha significantly *induced* [PHD3] , but not PHD1 or 2 , mRNA , and protein expression selectively in ECs directly via a JAK/STAT1 pathway as demonstrated by pharmacological inhibition , siRNA knockdown , and chromatin immunoprecipitation . Positive_regulation EGLN3 IFNG 19574556 2122221 *induces* [PHD3] through a JAK/STAT1 dependent mechanism in human ECs . Positive_regulation EGLN3 IL1A 22948157 2697697 Here , we show that in NP cells , TNF-a and *induce* [PHD3] expression through NF-?B . Positive_regulation EGLN3 PPP3CA 15189990 1256793 modifies the distribution of Hph1p within the endoplasmic reticulum and is *required* for full [Hph1p] activity in vivo . Positive_regulation EGLN3 PPP3CB 15189990 1256794 modifies the distribution of Hph1p within the endoplasmic reticulum and is *required* for full [Hph1p] activity in vivo . Positive_regulation EGLN3 PPP3CC 15189990 1256795 modifies the distribution of Hph1p within the endoplasmic reticulum and is *required* for full [Hph1p] activity in vivo . Positive_regulation EGLN3 SETD2 22451659 2594894 Reporter analysis shows that the hypoxic induction of the PHD2 promoter is HIF-1a dependent , whereas [PHD3] promoter/enhancer activity is *dependent* on both and HIF-2a . Positive_regulation EGLN3 SIAH1 15210114 1261887 Here , we demonstrate that the abundance of PHD1 and [PHD3] are *regulated* via their targeting for proteasome dependent degradation by the E3 ubiquitin ligases , under hypoxia conditions . Positive_regulation EGLN3 SIAH2 17003045 1641108 We show that Siah2 is subject to phosphorylation by p38 MAPK , which increases *mediated* degradation of [PHD3] . Positive_regulation EGLN3 SIAH2 17003045 1641109 Consistent with these findings , MKK3/MKK6 double-deficient cells , which can not activate p38 kinases , exhibit impaired *dependent* degradation of [PHD3] . Positive_regulation EGLN3 SLC22A3 24367580 2881795 We also found that induction of in MDCK cells *resulted* in the specific downregulation of [PHD3] , whereas the expression of the other HIF-PHD enzymes was not affected . Positive_regulation EGLN3 TNF 22948157 2697696 Here , we show that in NP cells , and IL-1ß *induce* [PHD3] expression through NF-?B . Positive_regulation EGR1 ANGPT1 19112164 2024840 *triggers* significant and transient induction of [Egr-1] , and Egr-1 contributes to Ang-1 induced endothelial cell migration and proliferation . Positive_regulation EGR1 CCND1 19936545 2190472 Thus , ED5 can specifically inhibit [Egr-1] expression , and probably *inhibits* VSMC proliferation by down regulating the expressions of and TGF-beta1 . Positive_regulation EGR1 EDN2 8060311 268220 Three groups of responses could be distinguished : 1. AII , , phenylephrine , and PMA *induced* [Egr-1] mRNA accumulation , but the message remained untranslated . Positive_regulation EGR1 EPHB2 10506481 649279 In adult rat VSMCs , Ang II activates and JNK , but weakly *induces* [Egr-1] , a transcription factor implicated in PDGF-B chain gene expression , compared with newborn VSMCs . Positive_regulation EGR1 EPHB2 11331872 808909 *induces* p35 , a neuron-specific activator of Cdk5 , through induction of [Egr1] . Positive_regulation EGR1 EPHB2 11948693 930253 Proliferation , *activation* of , and biosynthesis of [Egr-1] was completely inhibited in EGF or thrombin treated HaCaT cells by the MAP kinase kinase inhibitor PD98059 and by AG1487 , an EGF receptor-specific tyrosine kinase inhibitor . Positive_regulation EGR1 EPHB2 12411479 1010825 The Raf-1/B-Raf double deficient DT40 cells show an almost complete block both in activation and in the *induction* of the immediate early gene products c-Fos and [Egr-1] . Positive_regulation EGR1 EPHB2 12566441 1071736 Furthermore , this activation of signaling by the EP(4) receptors *induces* the functional expression of [early growth response factor-1 (EGR-1)] . Positive_regulation EGR1 EPHB2 12680875 1077309 Since the intracellular signalling of SDF-1 induced neovascularization remains unclear , we studied in human umbilical arterial endothelial cells ( HUAEC ) the influence of SDF-1alpha on induction of the genes of [early growth response-1 (Egr-1)] and VEGF , as well as the *activation* of 1/2 , which are all known to be involved in endothelial cell proliferation . Positive_regulation EGR1 EPHB2 15355986 1334099 G-protein mediated activation *enhanced* the transcription of [early growth response 1] , whereas beta-arrestin 2-dependent ERK activation did not . Positive_regulation EGR1 EPHB2 15910736 1412026 Activation of extracellular signal regulated protein kinase ( ) *triggers* the biosynthesis of [Egr-1] , a zinc finger transcription factor . Positive_regulation EGR1 EPHB2 16551742 1542079 In RAW macrophages in vitro , hypoxia induced Egr-1 mRNA expression was ERK dependent , and CO-mediated suppression of activation *resulted* in [Egr-1] inhibition . Positive_regulation EGR1 EPHB2 16806162 1585955 The increased expression of [Egr-1] and Bcl-2 by isoflurane was *inhibited* by inhibition . Positive_regulation EGR1 EPHB2 17065146 1654699 Inhibitors of and JNK ( but not of p38 MAPK ) *reduced* [egr-1] expression at the protein level . Positive_regulation EGR1 EPHB2 17474086 1772247 These results indicate that phosphorylation and activation of extracellular signal regulated protein kinase , elevated levels of intracellular Ca ( 2+ ) and the transactivation of the EGF receptor are *essential* for BzATP induced upregulation of [Egr-1] . Positive_regulation EGR1 EPHB2 17516844 1745842 We further show that the up-regulation of [EGR1] in MCF7/KEPI cells is *mediated* by signaling . Positive_regulation EGR1 EPHB2 18682391 1967679 Using specific pharmacological inhibitors and small interfering RNA technology , we determined that PKCdelta and , but not p38 and JNK , mediate histamine *induced* [Egr-1] expression . Positive_regulation EGR1 EPHB2 18783846 2012137 Moreover , diacylgycerol dependent protein kinase C isoenzymes and activation of extracellular signal regulated protein kinase ( ) are *required* for glucose- , tolbutamide- and KCl induced [Egr-1] expression . Positive_regulation EGR1 EPHB2 19372235 2094572 The effects of ERK pathway ablation on LH biosynthesis underlie this gender-specific phenotype , and the molecular mechanism involves a requirement for *dependent* up-regulation of the transcription factor [Egr1] , which is necessary for LHbeta expression . Positive_regulation EGR1 EPHB2 19786304 2163910 We further demonstrate that [Egr-1] induction is *triggered* by TNF-alpha dependent activation , and inhibition of this pathway ablates Egr-1 expression . Positive_regulation EGR1 EPHB2 20368687 2266698 Further analysis showed that the and JNK MAP kinases are *required* for induction of [Egr-1] by CPZ . Positive_regulation EGR1 EPHB2 20981109 2376219 Use of pharmacological inhibitors demonstrated that SLS induced [egr-1] was *dependent* on MEK1/p44/42 , but not on p38 or JNK signaling . Positive_regulation EGR1 EPHB2 21224049 2379378 The accumulation of [EGR-1] and GGPPS was *induced* by pathway activation when Beas-2B human bronchial epithelial cells were exposed to cigarette smoke extract (CSE) . Positive_regulation EGR1 EPHB2 21559295 2429475 Convulsant doses of a dopamine D1 receptor agonist result in *dependent* increases in [Zif268] and Arc/Arg3.1 expression in mouse dentate gyrus . Positive_regulation EGR1 EPHB2 8855340 388223 Urea-inducible [Egr-1] transcription was a *consequence* of activation because the ERK-specific inhibitor , PD98059 , abrogated transcription from the murine Egr-1 promoter in a luciferase reported gene assay . Positive_regulation EGR1 ID1 17878368 1796991 Id3 is presumably essential for traversal of the beta-selection checkpoint in this context because of the inability of other inhibitor of DNA binding family members to compensate , since transgenic [Egr1] does not *induce* expression of or 2 ( Id2 ) . Positive_regulation EGR1 IL1B 12637574 1085763 *induced* [Egr-1] binds strongly to the -119/-112 bp site , and mutations that block Egr-1 binding prevent inhibition by IL-1beta . Positive_regulation EGR1 IL1B 12637574 1085764 Our results indicate that *induced* activation of [Egr-1] binding is required for inhibition of COL2A1 proximal promoter activity and suggest that Egr-1 acts as a repressor of a constitutively expressed collagen gene by preventing interactions between Sp1 and the general transcriptional machinery . Positive_regulation EGR1 IL1B 17631285 1787500 Overexpression of [early growth response-1 (Egr-1)] in VSMC *induced* Id2 expression while induced Id2 expression was abrogated in VSMC by the Egr-1 repressor , NGFI-A binding protein 2 (NAB2) , expressed from an adenovirus . Positive_regulation EGR1 IL1B 18044710 1867305 We reported previously that early *activation* of [EGR-1] by results in suppression of the proximal COL2A1 promoter activity by displacement of Sp1 from GC boxes . Positive_regulation EGR1 IL1B 20018936 2210816 *induction* of [EGR-1] transcription involves histone H3 phosphorylation , acetylation , and autoregulation by EGR-1 . Positive_regulation EGR1 IL1B 22792188 2628260 Here we show that [Egr-1] expression *induced* by is dependent on metalloproteinases ( MMP ) and a disintegrin and a metalloproteinase ( ADAM ) . Positive_regulation EGR1 IL1B 22792188 2628315 Pharmacologic MMP/ADAM inhibitors and siRNA knockdown prevent *induction* of [Egr-1] . Positive_regulation EGR1 IL1B 22792188 2628394 Further , *activates* [Egr-1] via the epidermal growth factor receptor (EGFR) . Positive_regulation EGR1 IL1B 22792188 2628395 *induction* of [Egr-1] expression is reduced in murine embryonic fibroblasts ( mEFs ) deficient in ADAM17 despite unbiased expression of EGFR and IL-1RI in ADAM17-deficient and wild-type mEFs . Positive_regulation EGR1 IL1B 22792188 2628441 This study reports for the first time that [Egr-1] *induction* by involves EGFR and MMP/ADAM dependent EGFR phosphorylation . Positive_regulation EGR1 IL1B 8709978 371267 *Induction* of [early growth response-1] gene by and tumor necrosis factor-alpha in normal human bone marrow stromal an osteoblastic cells : regulation by a protein kinase C inhibitor . Positive_regulation EGR1 IL1B 8709978 371268 Our results demonstrate the expression of [Egr-1] gene and its *induction* by , and TNF-alpha in normal human bone marrow stromal ( osteoprogenitor ) and osteoblastic cells in primary cultures . Positive_regulation EGR1 IL1B 8709978 371269 Data also reveal that the expression of Egr-1 gene is inhibited by protein kinase C inhibitor H-7 suggesting that the activation of protein kinase C or other protein kinases resulting in the phosphorylation of specific transcription factor ( s ) is the first immediate early step in the *induction* of immediate-early [Egr-1] gene by , and TNF-alpha . Positive_regulation EGR1 MAP2K6 10501181 648254 Cholinergic stimulation of [early growth response-1] DNA binding activity *requires* protein kinase C and activation and is inhibited by sodium valproate in SH-SY5Y cells . Positive_regulation EGR1 MAP2K6 11150318 770582 Conversely , inhibition of does not *impair* [Egr] family mediated transcription . Positive_regulation EGR1 MAP2K6 11342553 827706 In contrast , activation of fos and [egr1] occurred independently of RhoA and actin polymerization but was almost completely *dependent* on activation . Positive_regulation EGR1 MAP2K6 12657697 1073312 In vivo THC induced the expression of immediate-early genes products ( c-Fos protein , [Zif268] , and BDNF mRNAs ) , and this induction was *prevented* by an inhibitor of . Positive_regulation EGR1 MAP2K6 15019950 1221166 In contrast , both inhibition and BMP signaling *suppressed* transcription of the serum-response element ( SRE ) -driven [Egr1] gene . Positive_regulation EGR1 MAP2K6 16864584 1613470 A functional MEK-ERK pathway is an important requirement for CB1 mediated Krox-24 induction as blockade of signaling by UO126 reduces both basal and CB1 mediated *activation* of [Krox-24] . Positive_regulation EGR1 MAP2K6 17516844 1745848 We further show that the up-regulation of [EGR1] in MCF7/KEPI cells is *mediated* by signaling . Positive_regulation EGR1 MAP2K6 19249349 2062676 Through inhibitor assays , we have further shown that is *required* for FGF1 induced neurite outgrowth , pSTAT3 ( S727 ) and [Egr1] expression . Positive_regulation EGR1 MAP2K6 19931294 2203783 Upregulation of [Egr-1] in hepatocytes by DCA and CDCA was *prevented* by the inhibitors U0126 and SL-327 . Positive_regulation EGR1 MMP28 22792188 2628292 Pharmacologic inhibitors and siRNA knockdown prevent IL-1beta *induction* of [Egr-1] . Positive_regulation EGR1 MMP7 22792188 2628330 Pharmacologic inhibitors and siRNA knockdown prevent IL-1beta *induction* of [Egr-1] . Positive_regulation EGR1 NR2F1 24227652 2876068 Finally , lentiviral vector mediated COUP-TFI deletion in adult generated interneurons confirmed that *acts* cell-autonomously in the control of TH and [ZIF268] expression . Positive_regulation EGR1 PTGER2 12566441 1071746 Under the same conditions induction of [EGR-1] protein expression was not *observed* following PGE ( 2 ) stimulation of receptors . Positive_regulation EGR1 STK39 1408148 200822 The constitutively active encoded by the v-raf oncogene , v-Raf , *activates* the [Egr-1] promoter in transient expression assays . Positive_regulation EGR1 TNF 11149911 780447 mediated *activation* of MEK/ERK and [EGR-1] can be blocked by adenoviral expression of a dominant negative mutant of IKK2 , whereas the VEGF signaling pathway is unaffected . Positive_regulation EGR1 TNF 11689211 876132 *induces* expression of transcription factors c-fos , [Egr-1] , and Ets-1 in vascular lesions through extracellular signal regulated kinases 1/2 . Positive_regulation EGR1 TNF 11689211 876138 In cultured rat aortic VSMC , ( 100 U/ml ) *stimulated* a rapid and transient expression of Ets-1 , [Egr-1] and c-fos with a maximal induction 1 h after stimulation . Positive_regulation EGR1 TNF 11689211 876141 In cultured RAW 264.7 mouse macrophages , similarly *induced* the expression of Ets-1 , [Egr-1] , and c-fos . Positive_regulation EGR1 TNF 15149634 1248416 IL-1 and *induced* [egr-1] and all AP-1 member expression , except fosB and junD . Positive_regulation EGR1 TNF 18227157 1884342 It was shown that these three proteins could ( i ) induce expression of and tissue factor and ( ii ) *induce* phosphorylation of p44/42 mitogen activated protein kinases (MAPK) and activation of [early growth response factor 1 (Egr-1)] . Positive_regulation EGR1 TNF 18227157 1884381 Treatment of cells with a MEK1/2 inhibitor , U0126 , dramatically reduced the phosphorylation of ERK , *activation* of [Egr-1] , and expression of in macrophages treated with recombinant proteins . Positive_regulation EGR1 TNF 18675783 1955180 Inhibition of the ERK or JNK pathway suppressed *induced* [EGR-1] expression , resulting in the inhibition of TNFalpha induced TNFalpha promoter activation . Positive_regulation EGR1 TNF 19786304 2163909 We further demonstrate that [Egr-1] induction is *triggered* by dependent ERK activation , and inhibition of this pathway ablates Egr-1 expression . Positive_regulation EGR1 TNF 21212994 2726118 Both glucose and *increased* [Egr-1] expression , while simultaneous exposure to the two factors exerted an additive effect . Positive_regulation EGR1 TNF 21212994 2726120 The MEK inhibitor , PD98059 , downregulated *induced* [Egr-1] expression . Positive_regulation EGR1 TNF 21212994 2726122 *induced* [Egr-1] protein expression and PAI-1 levels through the ERK1/2 pathway . Positive_regulation EGR1 TNF 23427178 2771289 We hypothesized that altered expression of ovarian [EGR1] is *induced* by elevated peritoneal fluid which is upregulated by the presence of peritoneal endometriosis . Positive_regulation EGR1 TNF 8709978 371266 *Induction* of [early growth response-1] gene by interleukin-1 beta and in normal human bone marrow stromal an osteoblastic cells : regulation by a protein kinase C inhibitor . Positive_regulation EGR1 TNF 9437186 474867 The present studies are the first to demonstrate that PMA , but not LPS , , and thrombin , *induced* [Egr-1] binding to the second serum-responsive region ( SRR-2 ) of TF promoter and that curcumin inhibited the PMA induced Egr-1 binding to SRR-2 . Positive_regulation EGR1 TNF 9542779 498127 *induces* the transcription factor [Egr-1] , pro-inflammatory cytokines and cell proliferation in human skin fibroblasts and synovial lining cells . Positive_regulation EGR2 EPHB2 24711453 2949556 Furthermore , our data shows that expression of [Egr2] in response to specific ligation of TREM-1 is *mediated* . Positive_regulation EGR2 MAP2K6 11150318 770589 Conversely , inhibition of does not *impair* [Egr] family mediated transcription . Positive_regulation EGR3 MAP2K6 11150318 770596 Conversely , inhibition of does not *impair* [Egr] family mediated transcription . Positive_regulation EGR4 MAP2K6 11150318 770603 Conversely , inhibition of does not *impair* [Egr] family mediated transcription . Positive_regulation EHMT1 TNF 11895929 920808 At 6 h of incubation , [GLP] *induced* a significant rise in alpha levels , which dropped progressively until 72 h of incubation . Positive_regulation EIF2AK2 FAS 10191197 603507 Expression of an inactive form of [PKR] ( K296R ) or the vector alone did not *induce* apoptosis or elevate mRNA levels . Positive_regulation EIF2AK2 FAS 9990139 597286 In addition , *increased* endogenous [PKR] activities . Positive_regulation EIF2AK2 FOXO1 20685959 2322826 In contrast , [PKR] regulates IRS2 , another major IRS family protein in the liver , at the transcriptional rather than the posttranslational level , and this effect is *mediated* by the transcription factor , , which has been previously shown to be regulated by insulin and plays a significant role in glucose homeostasis and energy metabolism . Positive_regulation EIF2AK2 IL1B 12051728 950605 *potentiated* IFN-alpha induced 2 ( ` ) 5 ( ` ) -OAS and [PKR] gene expression , similar to expression of the transfected reporter genes containing the IFN stimulated regulatory elements , while IL-10 suppressed IFN-alpha stimulated gene expression . Positive_regulation EIF2AK2 IL1B 18653246 1954842 Moreover , prolonged or TNF-alpha treatment *activated* double stranded RNA activated protein kinase ( [PKR] ) . Positive_regulation EIF2AK2 TNF 16153435 1455349 Inhibition of expression by tetracycline *resulted* in downregulation of [PKR] and decreased apoptosis . Positive_regulation EIF2AK2 TNF 16717090 1584797 treatment *induced* eIF2alpha phosphorylation and activation of caspase 3 primarily through the dsRNA activated eIF2alpha kinase [PKR] . Positive_regulation EIF2AK2 TNF 16861340 1588895 Thus , knock-down of RAX expression by 80 % using small interfering RNA ( siRNA ) prevents *induced* [PKR] activation and eIF2alpha phosphorylation , IkappaB degradation , IRF-1 expression , and STAT1 phosphorylation , resulting in enhanced murine embryonic fibroblast (MEF) cell survival . Positive_regulation EIF2AK2 TNF 9737981 531659 This p53 induction lags behind the *induction* of [PKR] by 1 h . Positive_regulation EIF2AK2 TNF 9737981 531660 This latter result indicates that p53 induction is an event downstream of *induced* up-regulation of [PKR] , thereby further establishing the critical role of p53 in TNF-alpha induced apoptosis in U937 cells . Positive_regulation EIF2AK4 EPHB2 18287093 1891421 Furthermore , the enhanced phosphorylation following amino acid deprivation *required* [GCN2] kinase activity and eIF2alpha phosphorylation . Positive_regulation EIF2S1 EPHB2 18287093 1891422 Furthermore , the enhanced phosphorylation following amino acid deprivation *required* GCN2 kinase activity and [eIF2alpha] phosphorylation . Positive_regulation EIF2S1 FAS 18719356 1961598 We noted , however , in these systems that , in parallel with death receptor induced activation of the extrinsic pathway , signaling also *promoted* increased phosphorylation of PKR-like endoplasmic reticulum kinase ( PERK ) and [eIF2alpha] , increased expression of ATG5 , and increased processing of LC3 and vesicularization of a GFP-LC3 construct . Positive_regulation EIF2S1 IL1B 15605392 1402227 treatment *induced* PERK and [eIF2-alpha] phosphorylation , but not GADD153 expression or apoptosis . Positive_regulation EIF2S1 IL1B 20411335 2274329 also *led* to increased phosphorylation of [eIF2alpha] and all these events could be prevented by pretreatment with the JNK inhibitor , SP600125 . Positive_regulation EIF2S1 MAP2K6 18287093 1891405 signaling is *required* for phosphorylation of [eIF2alpha] following amino acid limitation of HepG2 human hepatoma cells . Positive_regulation EIF2S1 MAP2K6 18287093 1891412 The present studies demonstrate that inhibition of activation in HepG2 human hepatoma cells by PD98059 or U0126 *blocked* the increased phosphorylation of [eIF2alpha] and ATF4 synthesis triggered by amino acid limitation , showing that the AAR requires activation of the MEK-ERK pathway . Positive_regulation EIF2S1 MAP2K6 18287093 1891431 Inhibition of protein phosphatase 1 action on phospho-eIF2alpha by knockdown of GADD34 did not block the sensitivity to PD98059 , suggesting that functions to *enhance* GCN2 dependent [eIF2alpha] phosphorylation rather than suppressing dephosphorylation . Positive_regulation EIF2S1 TNF 16717090 1584795 treatment *induced* [eIF2alpha] phosphorylation and activation of caspase 3 primarily through the dsRNA activated eIF2alpha kinase PKR . Positive_regulation EIF2S1 TNF 16861340 1588891 Thus , knock-down of RAX expression by 80 % using small interfering RNA ( siRNA ) prevents *induced* PKR activation and [eIF2alpha] phosphorylation , IkappaB degradation , IRF-1 expression , and STAT1 phosphorylation , resulting in enhanced murine embryonic fibroblast (MEF) cell survival . Positive_regulation EIF4B EPHB2 23707523 2806244 The results indicate mTOR independent phosphorylation of S6K1 and 4E-BP1 and suggest *dependent* phosphorylation of [eIF4B] during skeletal muscle contraction . Positive_regulation EIF4B MAP2K6 22546478 2602968 Inhibitors of , but not of TORC1/2 , *blocked* S6 and [eIF4B] phosphorylation and ?2 overexpression . Positive_regulation EIF4B MAP2K6 23707523 2806250 The results indicate mTOR independent phosphorylation of S6K1 and 4E-BP1 and suggest *dependent* phosphorylation of [eIF4B] during skeletal muscle contraction . Positive_regulation EIF4E EPHB2 10212283 607889 and 3 ) *dependent* [eIF4E] phosphorylation but not PI3-kinase dependent p70 ( S6k ) activation correlates with PGF2alpha induced global protein synthesis and bFGF-2 expression in VSMC . Positive_regulation EIF4E EPHB2 14581487 1186948 In addition , CD40 ligation was found to mediate a PI3K- and mammalian target of rapamycin (mTOR) dependent phosphorylation of 4E-BP1 and its subsequent dissociation from the mRNA cap binding protein eIF4E as well as an *dependent* phosphorylation of [eIF4E] , thus promoting translation initiation . Positive_regulation EIF4E EPHB2 14605021 1176298 PD98059 or introduction of kinase-inactive MEK1/MKK1 , but not SB202190 or kinase-inactive p38 MAP kinase , inhibited Ang II-induced Mnk1 activation and eIF4E phosphorylation , suggesting that , but not p38 MAP kinase , is *required* for Ang II-induced [Mnk1-eIF4E] activation . Positive_regulation EIF4E MAP2K6 10749669 762221 In serum starved cells , activation of protein synthesis , phosphorylation of eIF4E , and formation of the [eIF4F] complex , were *blocked* by inhibition of , a component of the extracellular regulated kinase (ERK) signalling pathway . Positive_regulation EIF4E MAP2K6 12581857 1058575 In the *presence* of the inhibitor , PD98059 , [eIF4E] phosphorylation was abolished and levels of cyclin D1 were dramatically reduced . Positive_regulation EIF4E TNF 1345341 209378 We report that both LPS and *stimulate* phosphorylation of [eIF-4E] and the p220 component of eIF-4F in bone marrow derived macrophages . Positive_regulation EIF4E TNF 17971516 1859763 *activated* two signaling cascades : 1 ) ERK1/2 and its target [eIF4E] and 2 ) Akt and its downstream effectors GSK-3 , p70 ( S6K ) , and 4E-BP1 . Positive_regulation EIF4E TNF 17971516 1859771 PD-98059 pretreatment abolished *induced* phosphorylation of ERK1/2 and [eIF4E] , whereas PS was only partially inhibited . Positive_regulation EIF4E TNF 2813400 121479 *induces* phosphorylation of a 28-kDa [mRNA cap binding protein] in human cervical carcinoma cells . Positive_regulation EIF4E TNF 2813400 121482 Thus , *stimulates* the phosphorylation of this [mRNA cap binding protein] , which may be involved in the transduction of TNF-alpha-receptor binding into cellular responses . Positive_regulation EIF4EBP1 EPHB2 23624914 2926204 Our recent study showed that both and AKT signaling are *required* to activate eukaryotic translation initiation factor 4E ( eIF4E ) -initiated cap dependent translation via convergent regulation of the translational repressor [4E-binding protein 1 (4E-BP1)] for maintaining CRC transformation . Positive_regulation EIF4EBP1 IL1B 19574449 2136759 At the protein level , [4E-BP1] was also up-regulated in *response* to starvation and , and this was blunted by HDLs . Positive_regulation EIF4EBP1 MAP2K6 11777913 916461 UVB induced phosphorylation of [4E-BP1] was *blocked* by p38 kinase inhibitors , PD169316 and SB202190 , and MSK1 inhibitor , H89 , but not by inhibitors , PD98059 or U0126 . Positive_regulation EIF4EBP1 MAP2K6 11799119 922301 Overexpression of constitutively active in HEK293 cells *resulted* both in the phosphorylation of [4E-BP1] at Ser ( 64 ) and Thr ( 36/45 ) and its release from eIF4E . Positive_regulation EIF4EBP1 OLFM4 20724538 2352006 Overexpression of in HL-60 cells *inhibited* constitutive and ATRA induced phosphorylation of the eukaryote initiation factor [4E-binding protein 1 (4E-BP1)] , whereas down-regulation of OLFM4 protein in acute myeloid leukemia-193 cells increased 4E-BP1 phosphorylation , suggesting that OLFM4 is a potent upstream inhibitor of 4E-BP1 phosphorylation/deactivation . Positive_regulation EIF4EBP1 TNF 17971516 1859764 *activated* two signaling cascades : 1 ) ERK1/2 and its target eIF4E and 2 ) Akt and its downstream effectors GSK-3 , p70 ( S6K ) , and [4E-BP1] . Positive_regulation EIF4EBP1 TNF 17971516 1859776 Rapamycin inhibited TNF-alpha induced phosphorylation of the mTOR C1 target p70 ( S6K ) without altering *induced* PS and [4E-BP1] phosphorylation . Positive_regulation EIF4G1 EPHB2 11154262 770702 Interestingly , we found that the association of both Mnk1 and Mnk2 with eIF4G increased upon inhibition of the MAPK pathways while activation of *resulted* in decreased binding to [eIF4G] . Positive_regulation EIF4G1 FAS 9821956 548685 In this study , we show that activation of the receptor complex in Jurkat cells *induces* the degradation of [eIF4G] , the inhibition of total protein synthesis and cell death . Positive_regulation EIF4G1 FAS 9821956 548688 Studies with the specific inhibitor , SB203580 , have shown that signalling through the p38 MAP kinase pathway is not required for either the *induced* cleavage of [eIF4G] or cell death . Positive_regulation EIF4G1 MAP2K6 10749669 762228 In serum starved cells , activation of protein synthesis , phosphorylation of eIF4E , and formation of the [eIF4F] complex , were *blocked* by inhibition of , a component of the extracellular regulated kinase (ERK) signalling pathway . Positive_regulation EIF4G2 EPHB2 11154262 770703 Interestingly , we found that the association of both Mnk1 and Mnk2 with eIF4G increased upon inhibition of the MAPK pathways while activation of *resulted* in decreased binding to [eIF4G] . Positive_regulation EIF4G2 FAS 9821956 548686 In this study , we show that activation of the receptor complex in Jurkat cells *induces* the degradation of [eIF4G] , the inhibition of total protein synthesis and cell death . Positive_regulation EIF4G2 FAS 9821956 548689 Studies with the specific inhibitor , SB203580 , have shown that signalling through the p38 MAP kinase pathway is not required for either the *induced* cleavage of [eIF4G] or cell death . Positive_regulation EIF4G3 EPHB2 11154262 770704 Interestingly , we found that the association of both Mnk1 and Mnk2 with eIF4G increased upon inhibition of the MAPK pathways while activation of *resulted* in decreased binding to [eIF4G] . Positive_regulation EIF4G3 FAS 9821956 548687 In this study , we show that activation of the receptor complex in Jurkat cells *induces* the degradation of [eIF4G] , the inhibition of total protein synthesis and cell death . Positive_regulation EIF4G3 FAS 9821956 548690 Studies with the specific inhibitor , SB203580 , have shown that signalling through the p38 MAP kinase pathway is not required for either the *induced* cleavage of [eIF4G] or cell death . Positive_regulation ELANE MMP28 12356583 993962 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with tumor necrosis factor (TNF)-alpha , known to induce matrix metalloproteinase (MMP) release , and/or [neutrophil elastase (NE)] , which can *induce* activation . Positive_regulation ELANE MMP7 12356583 993977 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with tumor necrosis factor (TNF)-alpha , known to induce matrix metalloproteinase (MMP) release , and/or [neutrophil elastase (NE)] , which can *induce* activation . Positive_regulation ELANE MUC16 12169572 973854 [Neutrophil elastase] *induces* production by ligand dependent epidermal growth factor receptor activation . Positive_regulation ELANE MUC16 16148149 1455123 [Neutrophil elastase] *induces* MUC5AC production in human airway epithelial cells via a cascade involving protein kinase C , reactive oxygen species , and TNF-alpha converting enzyme . Positive_regulation ELANE MUC16 18436821 1900346 Matrix metalloproteinase-7 and [neutrophil elastase] *induced* the release of but not of MUC1 or MUC4 . Positive_regulation ELAVL1 EPHB2 15371446 1334332 Collectively , our results indicate that PGA2 stabilizes the p21 mRNA through an ERK independent increase in cytoplasmic HuR levels and an *dependent* association of [HuR] with the p21 mRNA . Positive_regulation ELAVL1 EPHB2 23116706 2717437 5-Aminoimidazole-4-carboxamide ribonucleoside stabilizes low density lipoprotein receptor mRNA in hepatocytes via *dependent* [HuR] binding to an AU-rich element . Positive_regulation ELAVL1 EPHB2 23116706 2717446 Blocking signaling pathway activation *resulted* in attenuated [HuR] binding . Positive_regulation ELAVL1 IL1B 17208222 1695807 Thalidomide also suppressed IL-1beta induced p38 mitogen activated protein kinase (MAPK) activation , while a p38 MAPK inhibitor destabilized COX-2 mRNA and the cytoplasmic shuttling of [HuR] *induced* by . Positive_regulation ELAVL1 MAP2K6 19447225 2078702 Lopinavir induced cytosolic translocation of [HuR] and TNF-alpha and IL-6 synthesis was *attenuated* by specific chemical inhibitor of ( PD98058 ) or over-expression of dominant negative mutant of MEK1 . Positive_regulation ELAVL1 MAP2K6 21206905 2359251 Furthermore , LFA-1 mediated mRNA stabilization and [HuR] translocation in mouse splenic T cells was *dependent* on the phosphorylation of the , MKK3 , and its target MAP kinase p38MAPK , and lost in T cells obtained from MKK3 gene deleted mice . Positive_regulation ELAVL1 SPHK1 23576579 2799912 The overexpressed *led* to increased checkpoint kinase 2 and enhanced [HuR] phosphorylation which allowed for increased translation of c-Myc mRNA through HuR binding at the 3'-untranslated regions . Positive_regulation ELAVL1 TNF 20306475 2315261 Sesamin and sesamol reduced the marked *induced* increase in human antigen R (HuR) translocation and the interaction between [HuR] and the 3'UTR of ICAM-1 mRNA . Positive_regulation ELF2 ANGPT1 11967990 938069 In addition , directly *induced* expression of [NERF2] in quiescent cells . Positive_regulation ELF2 ANGPT1 11967990 938070 These novel findings suggest that *regulates* expression of [NERF2] and its own receptor in hypoxic cells . Positive_regulation ELF3 EPHB2 22158614 2542857 Further , we found that signaling *enhances* [ELF3-driven] MMP13 transactivation and is required for IL-1ß induced ELF3 binding to the MMP13 promoter , as assessed by chromatin immunoprecipitation . Positive_regulation ELF3 IL1B 12746898 1088810 [ESE-1] mRNA expression could be *induced* by and TNFalpha in cells such as synovial fibroblasts , chondrocytes , osteoblasts , and monocytes . Positive_regulation ELF3 IL1B 12746898 1088812 Transient transfection experiments and EMSAs showed that *induction* of [ESE-1] gene expression by requires activation of NF-kappaB and binding of p50 and p65 family members to the NF-kappaB site in the ESE-1 promoter . Positive_regulation ELF3 IL1B 12746898 1088819 Overexpression of IkappaB using an adenoviral vector blocked *induced* [ESE-1] mRNA expression . Positive_regulation ELF3 MAP2K6 22158614 2542864 Further , we found that signaling *enhances* [ELF3-driven] MMP13 transactivation and is required for IL-1ß induced ELF3 binding to the MMP13 promoter , as assessed by chromatin immunoprecipitation . Positive_regulation ELF3 TNF 12746898 1088809 [ESE-1] mRNA expression could be *induced* by IL-1beta and in cells such as synovial fibroblasts , chondrocytes , osteoblasts , and monocytes . Positive_regulation ELK1 ABCA12 21622130 2436414 Moreover , significantly *promoted* transcriptional activity of [Elk1] and c-jun , which might , at least partly , be associated with activated ERK1/2 and JNK/SAPK signaling pathway . Positive_regulation ELK1 EPHB2 11997521 939449 Both the catalytic activity and , to a much lesser extent , the Grb2 binding-tyrosyl phosphorylation sites of SHP-2 are required for maximal FGF-2 induced activity and [Elk-1] *transactivation* . Positive_regulation ELK1 EPHB2 16956962 1673367 Finally , we present evidence indicating that SMC phenotypic switching involves multiple active repressor pathways , including Krüppel-like zinc finger type 4 , HERP , and *dependent* phosphorylation of [Elk-1] that act in a complementary fashion . Positive_regulation ELK1 EPHB2 17244536 1690770 In cortical neurons treated with nerve growth factors and in stimulated cardiomyocytes , PARP-1 activation enhanced *induced* [Elk1-phosphorylation] , core histone acetylation , and transcription of the Elk1-target gene c-fos . Positive_regulation ELK4 EPHB2 9111305 425572 In contrast , [SAP-1] is *activated* by and p38 MAP kinases but not by JNK . Positive_regulation ELK4 SLC38A3 9950815 595754 *induced* the transcriptional activity of both Elk-1 and [Sap-1a] , transcription factors that bind to the E26 transformation specific (Ets) DNA sequence of the SRE , and this effect was inhibited by both GF-109203X and PD-98059 . Positive_regulation ELL C1QTNF1 9002605 404752 The results of the present work support the possible *role* of in GA-induced corolla and stem [elongation] . Positive_regulation ELL EDN2 19393623 2075069 Thus , *induces* cortical neurite [elongation] through the endothelin A receptor by a mechanism dependent on JNK . Positive_regulation ELL ELOVL4 17304340 1699083 Furthermore , we suggest that is likely *involved* in the [elongation] of C26 and longer fatty acids . Positive_regulation ELL EPHB2 15067199 1231868 Taken together , the results demonstrate the functional *role* for and p23 in the neurite [elongation] activity of FK506 and reveal a novel signal transduction pathway involving p23 activation of ERK . Positive_regulation ELL EPHB2 18676449 1955188 The splice variants of UBF differentially regulate RNA polymerase I transcription [elongation] in *response* to phosphorylation . Positive_regulation ELL FAS 12687369 1078778 Six- and 20-h incubations were studied , and membrane fatty acids were monitored as internal controls for *mediated* [elongation] . Positive_regulation ELL FUT4 7696863 288017 The formation of these extended glycolipids is compatible with the concept that in the *presence* of reduced secretor activity , increased [elongation] of the precursor chain occurs , which supports the postulate that fucosylation of the precursor prevents or at least markedly reduces chain elongation . Positive_regulation ELL FUT4 7701811 288406 We also show that in the *presence* of reduced activity , increased [elongation] of the precursor chain occurs , which allows us to postulate that fucosylation of the precursor prevents or at least markedly reduces chain elongation . Positive_regulation ELL GPR115 20226789 2265828 Stimulation of results in uniform cell enlargement in all directions with an increase in skeletal alpha-actin ( alpha-SKA ) gene expression , while stimulation of gp130 receptor by interleukin-6 (IL-6) related cytokines *induces* longitudinal [elongation] with no increase in alpha-SKA gene expression . Positive_regulation ELL GPR132 20226789 2265817 Stimulation of results in uniform cell enlargement in all directions with an increase in skeletal alpha-actin ( alpha-SKA ) gene expression , while stimulation of gp130 receptor by interleukin-6 (IL-6) related cytokines *induces* longitudinal [elongation] with no increase in alpha-SKA gene expression . Positive_regulation ELL GPR87 20226789 2265897 Stimulation of results in uniform cell enlargement in all directions with an increase in skeletal alpha-actin ( alpha-SKA ) gene expression , while stimulation of gp130 receptor by interleukin-6 (IL-6) related cytokines *induces* longitudinal [elongation] with no increase in alpha-SKA gene expression . Positive_regulation ELL IGFBP1 19497977 2120637 These studies reveal that is a common endometrial marker of conceptus elongation in sheep and cattle and most likely *regulates* conceptus [elongation] by stimulating migration and attachment of the trophectoderm . Positive_regulation ELL ITGAL 22711877 2621436 Experiments with knockout mice and blocking antibodies reveal that the uropod [elongation] and microparticle formation are the *result* of mediated adhesion and VLA-3 mediated cell migration through the vascular basement membrane . Positive_regulation ELL MAP2K6 20869211 2337201 Overexpression of the constitutive active form of *resulted* in significant [elongation] of dendrites in the melanoma cell line SK-mel-24 . Positive_regulation ELL NT5E 15926911 1414197 A reduced amount of BDNF , but not , is *sufficient* to promote the [elongation] of regenerating axons in the PNS . Positive_regulation ELL PCDH19 18171927 1855793 and TAF1 *regulate* retinal axon initiation and [elongation] in vivo . Positive_regulation ELL PCDH8 18171927 1855798 and TAF1 *regulate* retinal axon initiation and [elongation] in vivo . Positive_regulation ELL SRGN 20032306 2205151 When introduced in neurons , is distributed in the plasma membrane and *induces* filopodia as well as axon [elongation] and growth . Positive_regulation ELL TMOD1 18984629 1989791 Thus , we propose a model in which and enhancers of actin dynamics synergistically *regulate* [elongation] and shortening of actin filaments at the pointed end . Positive_regulation ELL TNF 15569261 1343916 In the *presence* of , A2B AR stimulation in vitro induced the [elongation] of astrocytic processes , a typical morphological hallmark of in vivo reactive astrogliosis . Positive_regulation ELL TNF 16307187 1486480 Gradual nerve [elongation] by limb lengthening *induces* production of in Schwann cells . Positive_regulation ELL TNF 17071594 1637688 Mast cell derived can *promote* nerve fiber [elongation] in the skin during contact hypersensitivity in mice . Positive_regulation ELL TNF 17071594 1637690 Using genetically mast cell-deficient c-kit mutant mice selectively repaired of their dermal mast cell deficiency with either wild-type or tumor necrosis factor (TNF)-deficient mast cells , we found that mast cells , and mast cell derived , significantly *contributed* to the [elongation] of epidermal and dermal PGP 9.5+ nerves and dermal CGRP+ nerves , as well as to the inflammation observed at sites of contact hypersensitivity in response to oxazolone . Positive_regulation ELL TNF 17071594 1637692 These observations show that mast cells , and mast cell derived , can *promote* the [elongation] of cutaneous nerve fibers during contact hypersensitivity in the mouse . Positive_regulation ELL TNF 17476691 1772281 subsequently *caused* a progressive increase in permeability and in stress fiber reorganization , cell [elongation] , and intercellular gap formation over 8-24 h. Consistent with the increased permeability , Occludin and JAM-A were removed from tight junctions and ZO-1 was partially redistributed . Positive_regulation ELL TNF 22677561 2626198 [ELL] *induced* production of Type-1 cytokines such as IL-12 and from bone marrow derived dendritic cells ( BMDCs ) in TLR2- and TLR4 dependent manner and remarkably up-regulated the expression of MHC and co-stimulatory molecules . Positive_regulation ELL TNF 23116662 2717432 and TGF-ß synergistically *stimulate* [elongation] of human endothelial cells without transdifferentiation to smooth muscle cell phenotype . Positive_regulation ELL TNF 7690970 228703 The activity of TNF-p140trk chimeras was completely blocked by the tyrosine kinase inhibitor K252a , and was unable to *induce* neurite [elongation] in PC12 cells transfected with a tyrosine kinase-defective chimeric receptor . Positive_regulation ELL TP63 15863843 1401302 From these results , we suggest that may be *involved* in the early stage of the remodeling process of the psoriatic epidermis as well as in the [elongation] of the rete ridges . Positive_regulation ELN CTGF 18289887 1924835 *caused* a 2.5-fold increase in the expression of [elastin] in comparison to the control , resulting in enhanced deposition of elastin fibers in a monolayer culture of auricular chondrocytes . Positive_regulation ELN CTGF 23542855 2767123 *leads* to maximal [elastin] increase in UCMSCs after 7 days of chondroinduction and not in undifferentiated MSCs . Positive_regulation ELN HBEGF 12882762 1150059 *regulates* [elastin] and FGF-2 expression in pulmonary fibroblasts . Positive_regulation ELN IL1B 8454621 215312 *Enhancement* of the human [elastin] promoter activity by was also noted in fibroblast cultures established from the skin and lungs of transgenic mice which have integrated the human promoter/CAT construct into their genome and express it in a tissue-specific manner . Positive_regulation ELN IL1B 8575260 340868 Secondly , *enhancement* of the human [elastin] promoter activity by injected subcutaneously resulted in an approximately 10-fold elevation of the CAT activity . Positive_regulation ELN SLC2A10 20547159 2284895 In ATS , loss of *results* in defective collagen and/or [elastin] . Positive_regulation ELN TNF 20127972 2272275 In *response* to , tenocytes reduced their type I collagen deposition but increased their [elastin] gene expression and highly upregulated their expression for MMP-1 , pro-inflammatory ( TNFalpha , IL-1beta ) and immunoregulatory ( IL-6 , IL-10 ) cytokines . Positive_regulation ELN TNF 3138995 97363 and Interferon-gamma (IFN-gamma) significantly *enhanced* the [elastin] degrading activity present in the culture media of both synoviocytes and chondrocytes . Positive_regulation ELN ZFP57 22891920 2697370 Finally , we show in bioengineered blood vessels that *mediated* induction of [elastin] expression is capable of stimulating functional elastogenesis . Positive_regulation EMD EPHB2 16827720 1586655 Our results indicate that [EMD] *induces* the formation of osteoclasts through interaction with RANKL , while and p38 MAPK may play a critical role in the enhancement of osteoclast formation in RAW 264.7 cells . Positive_regulation EML1 ITGB2 9808058 545008 Similar to HL60 , MPRO and [EML] *induce* expression of and also exhibit downregulation of CD34 on differentiation . Positive_regulation EML2 ITGB2 9808058 545002 Similar to HL60 , MPRO and [EML] *induce* expression of and also exhibit downregulation of CD34 on differentiation . Positive_regulation EML2 TNF 7929199 274325 [EMAP II] also activated mononuclear phagocytes elevating cytosolic free calcium concentration , *inducing* and tissue factor , and stimulating chemotaxis . Positive_regulation EML3 ITGB2 9808058 545006 Similar to HL60 , MPRO and [EML] *induce* expression of and also exhibit downregulation of CD34 on differentiation . Positive_regulation EML4 EPHB2 21415216 2416602 Forced expression of [EML4-ALK] *induced* marked activation of extracellular signal regulated kinase ( ) and STAT3 , but not that of AKT . Positive_regulation EML4 ITGB2 9808058 545000 Similar to HL60 , MPRO and [EML] *induce* expression of and also exhibit downregulation of CD34 on differentiation . Positive_regulation EML5 ITGB2 9808058 545004 Similar to HL60 , MPRO and [EML] *induce* expression of and also exhibit downregulation of CD34 on differentiation . Positive_regulation EML6 ITGB2 9808058 545010 Similar to HL60 , MPRO and [EML] *induce* expression of and also exhibit downregulation of CD34 on differentiation . Positive_regulation EMP1 AGR2 18268030 1885020 In iron restricted growth conditions , Sae and are *essential* for [Emp] and Eap expression and hence for biofilm formation , whereas SarA appears to have a less-significant role . Positive_regulation EMP1 AGR3 18268030 1885019 In iron restricted growth conditions , Sae and are *essential* for [Emp] and Eap expression and hence for biofilm formation , whereas SarA appears to have a less-significant role . Positive_regulation EMP1 CRK 19192109 2049507 On the basis of the importance of p38 mitogen activated protein kinase (MAPK) in endothelial responses to inflammatory stimuli , we sought to define the *role* of in [EMP] generation and function . Positive_regulation EMP1 CSRP1 17351328 1720303 This study demonstrates that *induces* [EMP] generation in HUVECs and this effect is , at least in part , related to impaired BH ( 4 ) -dependent NO production . Positive_regulation EMP1 ERVK-6 8457590 215589 Activity of [EMP] on synthetic or protein substrates ( e.g. , collagen type-II and aggrecan of cartilage ) was completely *inhibited* by serine inhibitors , which was also found when using cartilage proteoglycan monomers . Positive_regulation EMP1 MET 10318834 611922 Our results indicate that Phe93 and Phe205 are important for both EPO and EMP1 binding , is not important for EPO binding but is *critical* for [EMP1] binding , and Thr151 is not important for binding either ligand . Positive_regulation EMP1 PON1 17129656 1716713 Interestingly , wt *caused* only 50 % degradation of racemic [EMP-MeCyC] , CMP-MeCyC and CMP-DDAO indicating complete hydrolysis of P ( + ) isomer . Positive_regulation EMP1 RUNX1 23924635 2830854 Hence , the *requirements* for in [EMP] and HSC formation are temporally distinct , and LT-HSC function is highly reliant on continued core binding factor activity . Positive_regulation EMP1 SERPINE1 10961539 726471 fused with erythropoietin (EPO) mimetic peptide ( EMP ) *enhances* the EPO activity of [EMP] . Positive_regulation EMP1 SH3D19 10481948 643752 These observations strongly infer that peptide . dimerization were *induced* by [EMP1] , and EMP37 but not by EMP13 , EMP26 or FMRF . Positive_regulation EMP1 TJP1 21501651 2434827 Previously we found that exposure to [electromagnetic pulse (EMP)] *induced* an increase in blood-brain-barrier ( BBB ) permeability and the degradation of in rats . Positive_regulation EMP1 TNFRSF10B 19265041 2063008 complex *mediated* [EMP] release by initiating the recruitment of adaptor proteins and the activation of nuclear factor kappaB . Positive_regulation EMP1 TNFSF10 19265041 2063009 complex *mediated* [EMP] release by initiating the recruitment of adaptor proteins and the activation of nuclear factor kappaB . Positive_regulation EMP2 AGR2 18268030 1885022 In iron restricted growth conditions , Sae and are *essential* for [Emp] and Eap expression and hence for biofilm formation , whereas SarA appears to have a less-significant role . Positive_regulation EMP2 TNFSF10 19265041 2063011 complex *mediated* [EMP] release by initiating the recruitment of adaptor proteins and the activation of nuclear factor kappaB . Positive_regulation EMP3 AGR2 18268030 1885024 In iron restricted growth conditions , Sae and are *essential* for [Emp] and Eap expression and hence for biofilm formation , whereas SarA appears to have a less-significant role . Positive_regulation EMP3 TNFSF10 19265041 2063013 complex *mediated* [EMP] release by initiating the recruitment of adaptor proteins and the activation of nuclear factor kappaB . Positive_regulation ENDOG CAPN8 16021180 1498130 In contrast , drug treatment caused [EndoG] translocation , *activation* of , and both the synthesis and activation of cathepsin D . Positive_regulation ENG CEACAM6 16115956 1448937 Microarray analysis revealed that engagement by several human pathogens *triggers* expression of [CD105] . Positive_regulation ENG PECAM1 21406632 2416500 By using region of interest ( ROI ) analysis , the DOS measure of total tissue hemoglobin ( Hb ( T ) ) was temporally correlated with quantitative measures of existing ( expressing ) and tumor *induced* ( [CD105] expressing ) vessels , in pretreatment and posttreatment tissue specimens , to assess change . Positive_regulation ENG PECAM1 24625025 2925469 Bevacizumab treatment *induced* significant low expression of mouse Pecam1/Cd31 , [Eng/Cd105] , Flt1/Vegfr1 and Kdr/Vefr2 while the human and VEGFA were upregulated . Positive_regulation ENG TNF 12820370 1103991 Our hypothesis is that [CD105] gene expression in endothelial cells is *regulated* by the multifunctional cytokines and TGF beta 1 . Positive_regulation ENG TNF 20065159 2201271 Angiotensin receptor agonistic autoantibody mediated induction *contributes* to increased soluble [endoglin] production in preeclampsia . Positive_regulation ENO1 PLAT 12828639 1104994 Plasminogen binds to surface displayed pneumococcal [alpha-enolase] ( Eno ) and is subsequently *activated* to the serine protease plasmin by host derived or urokinase ( uPA ) . Positive_regulation ENO2 S100B 20694777 2305947 The serum level of [NSE] increased significantly and the level of *increased* insignificantly after the tumor resection . Positive_regulation ENPEP CD14 18332207 1898173 The *activation* of ( + ) cells by [Eap] suggests that it could play a significant role in both septic shock and fever , two of the major pathological features of S. aureus infections . Positive_regulation ENPP1 FGF2 21678127 2538716 Real-time PCR analysis indicated that *upregulates* Ank , [Enpp1] , Mgp , Slc20a1 , and Dmp1 in MLO-Y4 cells . Positive_regulation ENPP1 GALNT2 23500900 2766686 *Role* of in the modulation of [ENPP1] expression , and insulin signaling and action : GALNT2 : a novel modulator of insulin signaling . Positive_regulation ENPP1 ICMT 23420746 2744127 It was found that down-regulation of [ENPP-1] gene expression *induced* by is likely dependent on TGF-ß1 in end-plate chondrocytes . Positive_regulation ENPP1 SERPINE1 22553514 2366934 The corresponding gene expression and function can affect POAG progress , including *roles* of in extracellular matrix , [ENPP1] in insulin inhibition , IL-6 in endogenous neuroprotection , IL-6 , IL-6R and E-Sel in autoimmune response , LIPC and FGB in blood hyperviscosity syndrome , ADIPOQ in NOS/NO production , PON1 in vascular endothelial protection . Positive_regulation ENPP2 PLAU 17013094 1629299 [Autotaxin] *induced* expression in a dose dependent manner that was inhibited by pharmacological inhibitors for Gi ( pertussis toxin ) , phosphoinositide 3-kinase ( PI3K , LY294002 ) , Akt inhibitor (AktI) , proteosome activity and IkappaB phosphorylation ( pyrrolidine dithiocarbamate ) , and by a dominant negative mutant ( DN ) of Akt . Positive_regulation ENPP3 ALOX5 15388786 1359157 The <5-lipoxygenase> products leuko-triene B ( 4 ) and 5-oxo-6,8,11,14-eicosatetraenoic acid also *stimulated* [CD203c] expression but to a lesser extent than PGD ( 2 ) , whereas leukotriene D ( 4 ) was inactive . Positive_regulation EOMES HBEGF 18411410 1894127 Our data show that culture in HBEGF and LIF appears to facilitate human embryo expression of a number of genes : ERBB4 ( LIF ) and LIFR and DSC2 ( HBEGF ) while in the *presence* of no blastocysts expressed [EOMES] and when cultured with LIF only two out of nine blastocysts expressed TBN . Positive_regulation EP300 CCND1 17178859 1662527 Surprisingly , they were all up-regulated by 17beta-estradiol and , and cyclin D1 overexpression *increased* [p300/CBP] binding to their promoters , supporting the model that cyclin D1-estrogen receptor (ER) coactivator interactions may be important to its role in ER-positive breast cancer . Positive_regulation EPAS1 EDN2 20574527 2280335 Here we found that in melanoma cells ET-1 , , and ET-3 through ET ( B ) R , *enhance* the expression and activity of HIF-1alpha and [HIF-2alpha] that in turn regulate the expression of vascular endothelial growth factor ( VEGF ) in response to ETs or hypoxia . Positive_regulation EPAS1 IL1B 12099714 962325 Such an *induction* of [EPAS1] by was efficiently inhibited by the pretreatment of the cells with Src kinase inhibitors , such as herbimycin A and PP1 . Positive_regulation EPAS1 IL1B 12099714 962326 These results suggest that *induces* the [EPAS1] at the transcriptional level , which in turn activates the AM gene . Positive_regulation EPAS1 TNF 10483875 643911 Taken together , the data showed that [hLF] and LPS had immunoregulatory properties with respect to LFA-1 expression on human PBMC and that these actions were *mediated* by monocytes and . Positive_regulation EPC1 ID1 18187653 1856844 We show that tumors induce expression of the transcription factor Id1 in the EPCs and that suppression of after metastatic colonization *blocked* [EPC] mobilization , caused angiogenesis inhibition , impaired pulmonary macrometastases , and increased survival of tumor bearing animals . Positive_regulation EPC1 IL1B 19851077 2209554 A20 expression reduced [EPC] *activation* by tumor necrosis factor-alpha and as determined from changes in vascular cell adhesion molecule 1 and E-selectin expression and decreased monocyte transmigration through a monolayer of EPCs . Positive_regulation EPC1 ITGB2 16825578 1591416 Essential *role* of in mediating [EPC] recruitment , angiogenesis , and repair to the infarcted myocardium . Positive_regulation EPC1 ITGB2 16825578 1591423 To further verify the functional *role* of in mediating [EPC] recruitment and repair to the infarcted myocardium , we used neutralizing antibody to block CD18 . Positive_regulation EPC1 ITGB2 16825578 1591427 Thus , our results suggest an essential *role* of in mediating [EPC] recruitment and the subsequent functional effects on the infarcted heart . Positive_regulation EPC1 PLAT 23063135 2833323 We hypothesized that *enhanced* [endothelial progenitor cell (EPC)] mobilization from bone marrow ( BM ) into the circulation and angiogenesis in murine critical limb ischemia (CLI) . Positive_regulation EPC1 TNF 19851077 2209553 A20 expression reduced [EPC] *activation* by and interleukin-1beta as determined from changes in vascular cell adhesion molecule 1 and E-selectin expression and decreased monocyte transmigration through a monolayer of EPCs . Positive_regulation EPC2 ID1 18187653 1856845 We show that tumors induce expression of the transcription factor Id1 in the EPCs and that suppression of after metastatic colonization *blocked* [EPC] mobilization , caused angiogenesis inhibition , impaired pulmonary macrometastases , and increased survival of tumor bearing animals . Positive_regulation EPC2 IL1B 19851077 2209556 A20 expression reduced [EPC] *activation* by tumor necrosis factor-alpha and as determined from changes in vascular cell adhesion molecule 1 and E-selectin expression and decreased monocyte transmigration through a monolayer of EPCs . Positive_regulation EPC2 ITGB2 16825578 1591418 Essential *role* of in mediating [EPC] recruitment , angiogenesis , and repair to the infarcted myocardium . Positive_regulation EPC2 ITGB2 16825578 1591424 To further verify the functional *role* of in mediating [EPC] recruitment and repair to the infarcted myocardium , we used neutralizing antibody to block CD18 . Positive_regulation EPC2 ITGB2 16825578 1591428 Thus , our results suggest an essential *role* of in mediating [EPC] recruitment and the subsequent functional effects on the infarcted heart . Positive_regulation EPC2 PLAT 23063135 2833324 We hypothesized that *enhanced* [endothelial progenitor cell (EPC)] mobilization from bone marrow ( BM ) into the circulation and angiogenesis in murine critical limb ischemia (CLI) . Positive_regulation EPC2 TNF 19851077 2209555 A20 expression reduced [EPC] *activation* by and interleukin-1beta as determined from changes in vascular cell adhesion molecule 1 and E-selectin expression and decreased monocyte transmigration through a monolayer of EPCs . Positive_regulation EPHA2 MAP2K6 19948216 2199023 Here we show that the expression of [EphA2] in in vitro cultured cells , is restricted to cells growing adherently and that adhesion induced EphA2 expression is *dependent* upon activation of the epidermal growth factor receptor (EGFR) , ( MEK ) and Src family kinases (SRC) . Positive_regulation EPHA3 TNF 12370298 995738 We show that *activates* [Etk] specifically through TNF receptor type 2 (TNFR2) as demonstrated by studies using a specific agonist to TNFR2 and TNFR2-deficient cells . Positive_regulation EPHA3 TNF 16902858 1608283 IN VITRO , G1 decreased nitric oxide production in LPS stimulated RAW 264.7 cells ( IC ( 50 ) = 41.60 microg/mL ) , and also the luciferase activity in *stimulated* [HEK] 293 cells transfected with NF-kappaB-luciferase reporter gene driven by the nuclear factor kappaB (NF-kappaB) ( IC ( 50 ) = 200 microg/mL ) . Positive_regulation EPHA3 TNF 19470239 2085326 In addition , phosphorylation and degradation of IkappaBalpha and translocation of NF-kappaB p65 were inhibited by these flavonoids in *stimulated* [HEK] 293 cells . Positive_regulation EPHA4 EPHB2 18410519 1944306 By electron microscopy , [EphA4] was mainly *detected* in axon terminals , whereas was more frequently detected in large dendritic shafts , in the hippocampus and cerebral cortex . Positive_regulation EPHA4 ZIC2 24360543 2881705 *induces* [EphA4] expression in dorsospinal neurons to prevent midline crossing while Robo3 is downregulated to ensure that axons enter the dorsal tracts instead of growing ventrally . Positive_regulation EPHB1 CTGF 11732999 885285 These inhibitors of MAPKK and MAPK suppressed phosphorylation of [ets-like gene-1 (Elk-1)] and nuclear activating transcription factor-2 ( Atf-2 ) *induced* by in a dose dependent manner , respectively . Positive_regulation EPHB1 EFNB1 12118063 964691 *Activation* of by [EphB1/Fc] induced phosphorylation of p46 JNK but not ERK-1/2 or p38 MAPkinases . Positive_regulation EPHB1 EFNB1 12223469 1012231 *Stimulation* of endogenous [EphB1] in embryonal carcinoma P19 cells with its ligand increased its association with Grb7 , which is consistent with a role for the autophosphorylation of EphB1 . Positive_regulation EPHB1 EFNB1 18034775 1852151 Here , we demonstrated that *stimulation* of [EphB1] with led to a marked downregulation of EphB1 protein , a process blocked by the lysosomal inhibitor bafilomycin . Positive_regulation EPHB1 EFNB1 20633976 2316723 Identification of expression in prostatic mesenchyme and a *role* for [EphB-EphrinB] signalling in prostate development . Positive_regulation EPHB1 EFNB1 22475621 2715224 *Activation* of [EphB] receptors by ( efnB ) ligands on neuronal cell surface regulates important functions , including neurite outgrowth , axonal guidance , and synaptic plasticity . Positive_regulation EPHB1 EFNB1 8798570 381674 The , LERK-2/Fc , *stimulated* tyrosine phosphorylation of [ELK] , and recruitment of Grb10 and Grb2 to endothelial ELK receptors recovered by wheat germ agglutinin lectin and immunoprecipitation . Positive_regulation EPHB1 EPHB2 12604337 1062607 These results suggest that merlin *inhibits* SRE dependent transactivation by repressing serum induced phosphorylation and its downstream effector , [Elk] phosphorylation . Positive_regulation EPHB1 EPHB2 12730243 1106910 We reduced the level of caveolin-1 in senescent human diploid fibroblasts using its antisense oligonucleotides and small interfering RNA , and this resulted in the restoration of normal growth factor responses such as the increased phosphorylation of , the nuclear translocation of p-Erk , and the subsequent *activation* of [p-Elk] upon epidermal growth factor stimulation . Positive_regulation EPHB1 TCN1 21555368 2449355 Production and persistence of these pain behaviors are well correlated with *induced* upregulation of [EphB1] receptor and its ligand ephrinB2 in the dorsal horn and primary sensory neurons . Positive_regulation EPHB1 TCN1 23973554 2873378 *increased* the expression of TLR4 and the [EphB1] receptor , the activation of astrocytes and microglial cells , and increased levels of interleukin-1ß (IL-1ß) and tumor necrosis factor-a (TNF-a) . Positive_regulation EPHB1 TCN1 23973554 2873385 The administration of EphB2-Fc suppressed the TCI induced increase of TLR4 expression but siRNA2 failed to affect *induced* [EphB1] expression . Positive_regulation EPHB1 ZIC2 18524895 1922977 Our results demonstrate that *upregulates* [EphB1] expression and define a link between a transcription factor and expression of a guidance receptor protein essential for axon guidance at the vertebrate midline . Positive_regulation EPHB2 ABCB1 20236757 2272846 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2 , Bcl-xL and XIAP ) , as well as *activation* of [Ras/MEK/ERK] and PI3K/Akt signaling . Positive_regulation EPHB2 ABCB1 21742513 2484182 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-8 is associated with increased expression of both multidrug resistance related genes ( ) and apoptosis inhibitory proteins ( Bcl-2 , Bcl-xL , and XIAP ) , as well as *activation* of PI3K/Akt and [Ras/MEK/ERK] signaling . Positive_regulation EPHB2 ABCC8 10783161 688169 expression *enhances* Ras- or EGF induced Raf and [ERK] activation but has no effect on ERK activation induced by active Raf or MEK . Positive_regulation EPHB2 ABCC8 16301319 1511039 These results demonstrate a regulatory role of Erbin in the Ras-Raf-MEK pathway , suggesting that Erbin may *inhibit* [ERK] activation by disrupting the interaction . Positive_regulation EPHB2 ABCC8 20051520 2211689 positively *regulates* [Ras/ERK] MAP kinase signaling by serving as a scaffold for Ras and Raf . Positive_regulation EPHB2 ABL1 11726515 884445 In vivo expression of a Grb2 mutant where Tyr209 was changed to phenylalanine enhanced induced [ERK] *activation* and fibroblast transformation , and potentiated and prolonged Grb2 mediated activation of Ras , mitogen activated protein kinase and c-Jun N-terminal kinase in response to EGF stimulation . Positive_regulation EPHB2 ABL1 12444544 1017452 These data implicate the Src kinase family in Stat5 and [Erk] *activation* downstream of , and identify myeloid-specific Src kinases as potential drug targets in CML . Positive_regulation EPHB2 ABL1 15681433 1370532 Expression of DN Shc reduced Ab-MLV pre-B-cell transformation and decreased the ability of to *stimulate* Ras activation and [Erk] phosphorylation in a Raf dependent but Rac independent fashion . Positive_regulation EPHB2 ABL1 20647774 2304859 Here we show that Abl is necessary for p38alpha/beta activation initiated by N-cadherin ligation , but in contrast to Cdo , is also *required* for N-cadherin dependent [ERK] activation . Positive_regulation EPHB2 ABL1 21715303 2471234 Using this vector in a murine syngeneic BM transplantation model for BCR-ABL induced chronic myeloid leukemia , we find that oncogene expression and target knockdown in primary hematopoietic cells with this vector is efficient both in vitro and in vivo , and demonstrate that Raf1 , but not BRAF , modulates dependent [ERK] *activation* and transformation of hematopoietic cells . Positive_regulation EPHB2 ABL1 8524249 335106 These results suggest that both Crk and Grb2 may contribute to the *activation* of [Erk] by oncogenic , whereas Nck is unlikely to participate in this pathway . Positive_regulation EPHB2 ACD 11956184 953634 cAMP stimulated Ras independent and *dependent* [ERK] phosphorylation and cell proliferation in B-Raf expressing cells , but inhibited growth in B-Raf lacking cells . Positive_regulation EPHB2 ACD 12402047 1009424 We conclude that cAMP induced regulation of [ERK] and *activation* of are independent processes . Positive_regulation EPHB2 ACD 15167895 1259143 ARMS is rapidly tyrosine phosphorylated after binding of neurotrophins to Trk receptors and provides a docking site for the CrkL-C3G complex , resulting in *dependent* sustained [ERK] activation . Positive_regulation EPHB2 ACD 15723799 1376773 Ras independent activation of [ERK] signaling via the torso receptor tyrosine kinase is *mediated* by . Positive_regulation EPHB2 ACD 20877310 2381757 Moreover , we found that negatively *regulated* GNDF induced [ERK] activation and neurite outgrowth . Positive_regulation EPHB2 ACD 21803531 2505344 The present study was undertaken to examine if opioid mediated mechanisms are involved in the reinforcing properties of and in ACD elicited [ERK] *activation* . Positive_regulation EPHB2 ACD 24523415 2924182 Moreover , our results showed that NMDA mediated activation of the small G-protein Ras is necessary for PI3K/Akt pathway activation , whereas was *involved* in NMDA phosphorylation of [ERK] . Positive_regulation EPHB2 ACKR3 22083878 2540818 Moreover , *mediated* effects of SDF-1 on [Erk] and Akt signaling as well as on astrocytic proliferation and migration were all sensitive to pertussis toxin . Positive_regulation EPHB2 ACP2 12415008 1011236 alpha8beta1 binding to *increased* cell proliferation and phosphorylation of FAK and [ERK] , but did not activate of TGFbeta1 . Positive_regulation EPHB2 ADA 12663040 1074327 CCY1a inhibition of Ca2+ entry , [ERK] , and Akt phosphorylation was not *prevented* by SQ22536 or . Positive_regulation EPHB2 ADAM17 20566668 2302742 EGFR transactivation is mediated by a disintegrin and metalloenzyme ( ADAM ) family members , which are required for both extracellular signal regulated kinase ( ERK ) and EGFR activation by BK. Using a gene silencing approach we observed that both BK-induced [ERK] activation and BK-induced permeability decrease in podocytes is *attenuated* by down-regulation , and we identified epiregulin (ER) as the EGFR ligand participating in ADAM dependent BK2R-EGFR cross-talk . Positive_regulation EPHB2 ADAM17 21411748 2432082 We show that Trk induced phosphorylation and generation of the p75NTR ( ICD ) is *required* for neurotrophin induced [Erk] and Akt activation and for neurotrophin dependent survival signaling . Positive_regulation EPHB2 ADAM8 19747075 2168242 Stimulation of fibroblast proliferation by the plant cysteine protease is independent of its proteolytic activity and *requires* [ERK] activation . Positive_regulation EPHB2 ADAM8 19747075 2168243 [ERK] phosphorylation *mediated* by was abolished in the presence of PD 98059 or U0126 , both MAPK cascade inhibitors . Positive_regulation EPHB2 ADAM8 19747075 2168245 These data suggest that the mitogenic effect of on fibroblasts is independent of its proteolytic activity , *requires* [ERK] phosphorylation , and involves activation of PLC . Positive_regulation EPHB2 ADAP1 16287813 1509648 Here we have shown that transient expression of in COS-7 cells *results* in specific activation of [ERK] , and the activation is inhibited by co-expression of a dominant negative form of Ras . Positive_regulation EPHB2 ADAP1 16287813 1509650 We have also found that a mutant form of centaurin-alpha1 that is unable to bind PIP3 fails to induce ERK activation and that a phosphatidylinositol 3-kinase inhibitor LY294002 inhibits *dependent* [ERK] activation . Positive_regulation EPHB2 ADAP1 16287813 1509651 These results suggest that *contributes* to [ERK] activation in growth factor signaling , linking the PI3K pathway to the ERK mitogen activated protein kinase pathway through its ability to interact with PIP3 . Positive_regulation EPHB2 ADCY1 11410589 849748 activation with forskolin ( FSK ) *caused* a time dependent increase in [ERK] activity and translocation from cytoplasm to nucleus , which correlated with an increase in StAR mRNA levels , StAR protein accumulation , and steroidogenesis . Positive_regulation EPHB2 ADCY1 16973907 1628035 Indeed , we observed similar isoform dependent association of AC1 with ERK , *activation* of [ERK] by stimulation of with forskolin , and AC1 dependent lengthening of doubling time , indicating that these properties of AC1 are cell autologous and likely result from AC1 dependent protein-protein interactions . Positive_regulation EPHB2 ADCY10 11410589 849747 activation with forskolin ( FSK ) *caused* a time dependent increase in [ERK] activity and translocation from cytoplasm to nucleus , which correlated with an increase in StAR mRNA levels , StAR protein accumulation , and steroidogenesis . Positive_regulation EPHB2 ADCY2 11410589 849749 activation with forskolin ( FSK ) *caused* a time dependent increase in [ERK] activity and translocation from cytoplasm to nucleus , which correlated with an increase in StAR mRNA levels , StAR protein accumulation , and steroidogenesis . Positive_regulation EPHB2 ADCY2 16278303 1525863 binding *led* to [ERK] activation in both FPR- and FPRL-1/ALX transfected cells , while ANXA1 caused ERK activation only in cells transfected with FPRL-1/ALX . Positive_regulation EPHB2 ADCY3 11410589 849750 activation with forskolin ( FSK ) *caused* a time dependent increase in [ERK] activity and translocation from cytoplasm to nucleus , which correlated with an increase in StAR mRNA levels , StAR protein accumulation , and steroidogenesis . Positive_regulation EPHB2 ADCY4 11410589 849751 activation with forskolin ( FSK ) *caused* a time dependent increase in [ERK] activity and translocation from cytoplasm to nucleus , which correlated with an increase in StAR mRNA levels , StAR protein accumulation , and steroidogenesis . Positive_regulation EPHB2 ADCY5 11410589 849752 activation with forskolin ( FSK ) *caused* a time dependent increase in [ERK] activity and translocation from cytoplasm to nucleus , which correlated with an increase in StAR mRNA levels , StAR protein accumulation , and steroidogenesis . Positive_regulation EPHB2 ADCY6 11410589 849753 activation with forskolin ( FSK ) *caused* a time dependent increase in [ERK] activity and translocation from cytoplasm to nucleus , which correlated with an increase in StAR mRNA levels , StAR protein accumulation , and steroidogenesis . Positive_regulation EPHB2 ADCY7 11410589 849754 activation with forskolin ( FSK ) *caused* a time dependent increase in [ERK] activity and translocation from cytoplasm to nucleus , which correlated with an increase in StAR mRNA levels , StAR protein accumulation , and steroidogenesis . Positive_regulation EPHB2 ADCY8 11410589 849755 activation with forskolin ( FSK ) *caused* a time dependent increase in [ERK] activity and translocation from cytoplasm to nucleus , which correlated with an increase in StAR mRNA levels , StAR protein accumulation , and steroidogenesis . Positive_regulation EPHB2 ADCY9 11410589 849756 activation with forskolin ( FSK ) *caused* a time dependent increase in [ERK] activity and translocation from cytoplasm to nucleus , which correlated with an increase in StAR mRNA levels , StAR protein accumulation , and steroidogenesis . Positive_regulation EPHB2 ADCYAP1 10940738 721085 [ERK] *activation* by VIP or and TRH were additive and both sensitive to the MEK inhibitors PD98059 and U0126 . Positive_regulation EPHB2 ADCYAP1 10940738 721088 These results demonstrate for the first time that VIP and *activate* [ERK] in GH4C1 cells . Positive_regulation EPHB2 ADCYAP1 10940738 721089 Cyclic AMP increase is sufficient to elicit ERK activation in these cells and thus likely to represent the transduction pathway underlying VIP- and *dependent* [ERK] activation . Positive_regulation EPHB2 ADCYAP1 11739023 885991 Thus our results suggest that *stimulates* [ERK] activation in alpha T3-1 cells , and that the functional effect of this ERK activation is increased DNA synthesis and cell proliferation rather then transcriptional activation of the alpha GSU gene . Positive_regulation EPHB2 ADCYAP1 12473665 1055931 However , PACAP induced GTP loading of Rap1 was not sufficient to account for [ERK] *activation* by because 1 ) PACAP elicited Rap1 GTP loading depended only on phospholipase C , whereas maximal stimulation of ERK by PACAP also required the activity of protein kinase A (PKA) , protein kinase C ( PKC ) , and calcium dependent signaling ; Positive_regulation EPHB2 ADCYAP1 14551200 1175541 Experiments involving the expression of the dominant negative mutants of Ras and Rap1 signaling ( RasN17 or Rap1N17 ) indicate that both GTPases Ras and Rap1 are recruited for the [ERK] *activation* by VIP and , whereas Rap1 is poorly involved in TRH or EGF induced ERK activation . Positive_regulation EPHB2 ADCYAP1 14592419 1159934 Possible involvement of a cyclic AMP dependent mechanism in *induced* proliferation and [ERK] activation in astrocytes . Positive_regulation EPHB2 ADCYAP1 14592419 1159935 These results suggest that *mediated* stimulation of [ERK] activity and proliferation of astrocytes may involve a cyclic AMP dependent , but PKA independent , pathway . Positive_regulation EPHB2 ADCYAP1 16493055 1528707 In this study , we found that , but not PACAP38 , specifically *stimulated* intracellular calcium mobilization and [ERK] phosphorylation in human neutrophils . Positive_regulation EPHB2 ADCYAP1 16493055 1528708 In addition , *induced* calcium increase and [ERK] phosphorylation were specifically inhibited by an FPRL1 antagonist , Trp-Arg-Trp-Trp-Trp-Trp ( WRW4 ) , thus supporting the notion that PACAP27 acts on FPRL1 . Positive_regulation EPHB2 ADCYAP1 16914291 1672871 K252a , an inhibitor of TrkA decreases *induced* Akt and [ERK] phosphorylation and calcium mobilisation resulting in decreases in intracellular H2O2 production and membrane upregulation of CD11b expression , both functions being inhibited after anti-NGF or anti-TrkA antibody treatment . Positive_regulation EPHB2 ADCYAP1 17995938 1851274 and forskolin *stimulated* the activation of extracellular signal regulated kinase ( [ERK] ) , mitogen activated protein kinase ( MAP ; p38 MAP kinase ) and c-Jun N-terminal kinase (JNK) . Positive_regulation EPHB2 ADCYAP1 18362103 1912676 Dominant negative Rap1 expression impairs both PACAP induced neuritogenesis and Egr1 activation by PACAP , suggesting that cAMP elevation and [ERK] *activation* by are linked through Rap1 . Positive_regulation EPHB2 ADCYAP1 21539889 2440223 *increased* [ERK] phosphorylation in PAC1R expressing cells to the same degree as TRH . Positive_regulation EPHB2 ADCYAP1 24303997 2916778 , but not PACAP-27 , *activated* [ERK] in glia , while both forms stimulated cellular cAMP production . Positive_regulation EPHB2 ADCYAP1 24696141 2938757 *induced* [ERK] activation in HEK cells expressing PAC1 receptors involves both receptor internalization and PKC signaling . Positive_regulation EPHB2 ADCYAP1 24696141 2938760 Inhibition of PAC1 receptor endocytosis and PKC activation completely blocked *stimulated* [ERK] activation . Positive_regulation EPHB2 ADCYAP1 24696141 2938761 In sum , our results show that PACAP/PAC1 receptor endocytosis and PLC/diacylglycerol/PKC activation represent two complementary mechanisms contributing to *induced* [ERK] activation . Positive_regulation EPHB2 ADIPOQ 16529829 1555150 Globular *increased* phosphorylation of both [ERK] and p38 MAP kinase and increased the nuclear translocation of active NF-kappaB . Positive_regulation EPHB2 ADIPOQ 20709750 2335568 *induced* [ERK] and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion . Positive_regulation EPHB2 ADIPOQ 20709750 2335578 Interestingly , the data also suggest *induced* changes in Akt and [ERK] phosphorylation and caspase-3 may occur independent of the level of AdipoR expression . Positive_regulation EPHB2 ADIPOQ 23424645 2744181 Inhibition of Syk abrogated *induced* VEGF-C expression and [ERK] phosphorylation . Positive_regulation EPHB2 ADM 10666504 665614 Okadaic acid completely reversed the ERK inhibition caused by adrenomedullin , suggesting that PP2A may be involved in the *mediated* changes in proliferation , apoptosis and [ERK] activity . Positive_regulation EPHB2 ADM 12667639 1075613 We investigated whether acts as an autocrine/paracrine growth factor for cultured rat VSMCs and whether coexpressions of RAMP isoform and CRLR may *mediate* p42/p44 [ERK/MAP] kinase activation by adrenomedullin . Positive_regulation EPHB2 ADM 12667639 1075618 Cotransfection of RAMP2 or RAMP3 with CRLR into rat VSMCs potentiated activation of cAMP activity , but not of p42/p44 [ERK/MAP] kinase activity in *response* to . Positive_regulation EPHB2 ADM 16157033 1455819 Western blot analysis showed that did not change the expression of t-MAPKs but *increased* p-SAPK/JNK and p-P38MAPK levels and decreased [p-ERK] level . Positive_regulation EPHB2 ADORA2A 16871530 1607379 ligation *stimulated* [ERK] phosphorylation , and A2A receptor mediated collagen production by dermal fibroblasts was blocked by MEK-1 inhibitors . Positive_regulation EPHB2 ADRA2A 10677489 668113 Surprisingly , we found that in COS-7 cells , [ERK] *activation* by the , like that mediated by both the beta ( 2 ) AR and the epidermal growth factor receptor (EGFR) , is sensitive to mechanistically distinct inhibitors of clathrin mediated endocytosis , including monodansylcadaverine , a mutant dynamin I , and a mutant beta-arrestin 1 . Positive_regulation EPHB2 ADRA2A 12036966 968325 In contrast , mediated [ERK] *activation* in COS-7 cells was enhanced by GsCT expression , consistent with the relief of a downstream inhibitory effect of PKA . Positive_regulation EPHB2 ADRA2A 17655843 1805027 In conclusion , *activates* [ERK] and Akt in intestinal cells by a common pathway which depends on PI3-kinase activation and results from EGF receptor transactivation , via an autocrine/paracrine pathway implying MMP activation and heparin-binding-EGF shedding . Positive_regulation EPHB2 ADRB1 12724327 1106585 GIPC interacts with the beta1-adrenergic receptor and regulates mediated [ERK] *activation* . Positive_regulation EPHB2 ADRB1 19037712 2194720 In this study , we investigated the molecular mechanism of mediated [ERK] *activation* in African green monkey kidney COS-7 cells . Positive_regulation EPHB2 ADRB2 10677489 668112 Accordingly , we compared ERK activation mediated by a GPCR that does not undergo agonist stimulated endocytosis , the alpha(2A) adrenergic receptor ( alpha(2A) AR ) , with [ERK] activation *mediated* by the ( beta ( 2 ) AR ) , which is endocytosed . Positive_regulation EPHB2 ADRB2 12391272 1007511 Stimulation of the ( beta ( 2 ) AR ) in human embryonic kidney (HEK) 293 cells *causes* a transient activation of Extracellular Signal Regulated Kinase ( [ERK] ) 1/2 . Positive_regulation EPHB2 ADRB2 16030021 1459483 Knockdown of PDE4D , but not PDE4B , amplifies isoprenaline stimulated phosphorylation of the by PKA and *activation* of extracellular signal regulated kinase ( [ERK] ) through G ( i ) . Positive_regulation EPHB2 ADRB2 16038799 1437477 Beta-arrestin2 enhances *mediated* nuclear translocation of [ERK] . Positive_regulation EPHB2 ADRB2 20045406 2205358 On the other hand , methyl-beta-cyclodextrin treatment did decrease *induced* [ERK] phosphorylation . Positive_regulation EPHB2 ADRBK2 23086955 2706841 We also found that nociceptin induced NOPR mediated JNK but not [ERK] signaling *requires* Ser-363 , , and Arrestin3 . Positive_regulation EPHB2 AGAP2 23527545 2787932 The Arf GAP interacts with ß-arrestin2 and *regulates* ß2-adrenergic receptor recycling and [ERK] activation . Positive_regulation EPHB2 AGAP2 23527545 2787936 In addition , formed a complex with endogenous ERK ( extracellular-signal regulated kinase ) and overexpression of AGAP2 *potentiated* [ERK] phosphorylation induced by ß2-adrenergic receptors . Positive_regulation EPHB2 AGRN 12717697 1083906 These studies indicate that *augments* a transient early phosphorylation of [ERK] in the presence of FGF-2 , and augments and sustains FGF-2 mediated increases in c-fos phosphorylation . Positive_regulation EPHB2 AGTR1 15205453 1281138 Differential kinetic and spatial patterns of beta-arrestin and G protein mediated [ERK] *activation* by the . Positive_regulation EPHB2 AGTR1 15530505 1335866 Our results showed an increase in [ERK] activation by 5-HT with a peak effect at 30 min and maximal *stimulation* with 5-HT . Positive_regulation EPHB2 AGTR1 18927221 2028688 Insulin competed with the *mediated* [ERK] activation and decrease in megalin expression . Positive_regulation EPHB2 AGTR1 18927221 2028690 Collectively the *mediated* [ERK] signaling is involved in suppressing megalin expression in the OK cell line , and insulin competes with this pathway . Positive_regulation EPHB2 AGTR1 21076532 2366076 In diabetic retinopathy , signaling *activates* [ERK] in the inner layers of the retina , causing UPS mediated excessive degradation of the synaptic vesicle protein , synaptophysin . Positive_regulation EPHB2 AGTR1 9699562 525134 Xylazine *induced* [ERK] phosphorylation mg/kg and reached a maximum at 10 mg/kg . Positive_regulation EPHB2 AGTR2 15205453 1281139 Differential kinetic and spatial patterns of beta-arrestin and G protein mediated [ERK] *activation* by the . Positive_regulation EPHB2 AHR 17934341 1813473 PD153035 , an EGFR inhibitor , as well as alpha-NF significantly reduced ERK phosphorylation , suggesting that [ERK] activation by TCDD was *mediated* by both EGFR and . Positive_regulation EPHB2 AHR 24163404 2916365 Taken together , dependent inhibition of the PI3K/AKT pathway , *activation* of [MAPK/ERK] and modulation of ERa is a novel mechanism underlying BNF mediated antitumor effects in breast cancer , which may represent a promising strategy to be exploited in future clinical trials . Positive_regulation EPHB2 AHSA1 12842814 1149644 [ERK] was not activated by force , but phosphorylation was *required* for force induced inhibition of SMA expression . Positive_regulation EPHB2 AHSA1 23570600 2768003 PGE1 time-dependently *induced* both phosphorylation of [ERK] and p38 in HUVEC , whereas ERK inhibitor , PD98059 , or inhibitor , SB203580 , blocked PGE1 induced VEGF expression of HUVEC , resulting in dramatically suppression of HUVEC proliferation and migration compared with PGE1 treatment alone ( 60 % and 55 % by PD98059 , 62 % and 51 % by SB203580 , respectively ) ; Positive_regulation EPHB2 AHSA1 8843216 387373 Differential *activation* of extracellular signal regulated kinase ( [ERK] ) 1 , ERK2 , , and c-Jun NH2-terminal kinase mitogen activated protein kinases by bacterial peptidoglycan . Positive_regulation EPHB2 AKAP5 16030021 1459482 RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase *mediated* switching of the beta2-adrenergic receptor to activation of [ERK] in HEK293B2 cells . Positive_regulation EPHB2 AKAP5 16246112 1471499 Beta-arrestin recruited phosphodiesterase-4 desensitizes the *mediated* switching of beta2-adrenoceptor signalling to activation of [ERK] . Positive_regulation EPHB2 AKT1 10910095 713901 Perhaps surprisingly , activation of M+ : ER* or expression of a constitutively active form of Akt *led* to rapid activation of [MAP/ERK Kinase (MEK)] and the extracellular signal regulated kinase ( ERK ) /mitogen activated protein ( MAP ) kinases in Rat1 cells . Positive_regulation EPHB2 AKT1 11454948 837873 Inhibition of activation *required* almost complete inhibition of [ERK] . Positive_regulation EPHB2 AKT1 12034359 948250 C ( 2 ) -ceramide induced a delayed activation of [ERK] ( > 1 h ) and a much later *activation* of ( > 3 h ) in human melanocytes . Positive_regulation EPHB2 AKT1 12138095 991536 Cell survival relied on two pertussis toxin-sensitive events , *activation* of [ERK] and activation of phosphatidylinositol 3-kinase <(PI3K)/Akt> by S1P . Positive_regulation EPHB2 AKT1 12670507 1076117 Interestingly , the suppression of [ERK-MAP] kinase activation in Csk ( - ) /Csk cells was *restored* by overexpression of a dominant negative . Positive_regulation EPHB2 AKT1 12704651 1082371 Moreover , 15dPGJ ( 2 ) did not induce activation of or *activation* of extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 AKT1 12874217 1114950 Constitutively active *enhances* Lck and [Erk] activities and influences thymocyte selection and activation . Positive_regulation EPHB2 AKT1 14973553 1212485 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both ERK/MAPK and signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 AKT1 15242975 1282054 when PI3K was inhibited , [ERK] phosphorylation could be *induced* by microinjected activated , indicating important cross-talk between the PI3K and ERK1/2 pathways . Positive_regulation EPHB2 AKT1 15337530 1291368 We have characterized the *role* of Drosophila PI3K and in [ERK] pathway activation involving insulin induced proliferation using Drosophila Schneider cells . Positive_regulation EPHB2 AKT1 15607817 1357022 Furthermore , U0126 and LY294002 , which respectively inhibit MEK *induced* [ERK] phosphorylation and PI3 kinase mediated phosphorylation had distinct effects on C3a induced responses . Positive_regulation EPHB2 AKT1 16954211 1633344 Under basal conditions , dopamine transporter knock-out mice show enhanced striatal DARPP-32 phosphorylation , *activation* of [ERK] , and inactivation of as compared with wild-type littermates . Positive_regulation EPHB2 AKT1 16984917 1640518 These results suggest that expression of a splice variant of CD99 contributes to the invasive ability of human breast cancer cells by up-regulating AP-1 mediated gene expression through the *dependent* [ERK] and JNK signaling pathways . Positive_regulation EPHB2 AKT1 18224693 1884237 These results imply that cisplatin induced [MEK/ERK] activation appears to mediate apoptotic cell death , but that constitutively activated and/or ERK pathway may *mediate* resistance to cisplatin in NSCLC cells . Positive_regulation EPHB2 AKT1 18310510 1904177 HG induces phosphoinositide 3- kinase [ PI3K ; inhibited by adenoviral ( Ad ) .dominant negative ( dn ) PI3Kp85 ] , Akt ( inhibited by Ad.dnAkt1 ) , and [ERK] ( inhibited by PD-98059 ) activation and *induces* IL-17 expression via PI3K -- > -- > ERK dependent signaling . Positive_regulation EPHB2 AKT1 18453753 1909247 IGF-1 counteracts dexa mediated apoptosis in the *presence* of reduced but increased [ERK] phosphorylation . Positive_regulation EPHB2 AKT1 18506372 1917983 ERK and inhibitors *inhibit* ECM induced [ERK] , AKT activation and cell proliferation . Positive_regulation EPHB2 AKT1 18509361 1971896 In a univariate analysis , shorter overall survival was associated with the presence of ulceration ( P=0.001 ) and BRAF exon 15 mutations ( P=0.005 ) as well as the absence of nuclear activation of ( P=0.022 ) and of cytoplasmic *activation* of [ERK] ( P=0.003 ) . Positive_regulation EPHB2 AKT1 18799725 1986897 Here , we report that mice lacking the transcription factor forkhead box O3a (FoxO3a) develop neutrophilia associated with inhibition of the up-regulation of negative regulator of cell proliferation , Sprouty related Ena/VASP homology 1 domain containing proteins 2 ( Spred2 ) and and [ERK] *activation* , in HSCs during hematopoietic recovery following myelosuppressive stress conditions . Positive_regulation EPHB2 AKT1 19186178 2054104 Interestingly , activation of signaling *had* differential effects on [ERK] and p38 activation . Positive_regulation EPHB2 AKT1 19191907 2127878 The studies with pharmacological inhibitors suggest that calpain inhibition mediated monocyte migration is *mediated* by activation of [ERK] , p38 , JNK , and Rac . Positive_regulation EPHB2 AKT1 19424594 2076401 Here , we showed that long-term ER stress resulted in inactivation of and *activation* of [ERK] in human hepatocellular carcinoma ( HCC ) cells . Positive_regulation EPHB2 AKT1 20177738 2272384 These observations indicate that Cbl-b promotes RBL-2H3 apoptosis induced by VP-16 or Ara-c , probably through inhibition of and *activation* of [ERK] . Positive_regulation EPHB2 AKT1 20207017 2237088 Neutrophil infiltration , ICAM , TNF-alpha and iNOS mRNA expression , neuronal apoptosis and the expression of p-JNK , pSTAT1 and [p-Erk] were reduced and *increased* on C5aR inhibition in MRL/lpr brains . Positive_regulation EPHB2 AKT1 20561929 2290086 The vasoprotective effect of JP05 through the activation of *dependent* eNOS and [MEK/ERK] pathways in brain endothelial cells . Positive_regulation EPHB2 AKT1 20688159 2363410 Overexpression of *down-regulated* [ERK] activity inhibiting Ser 259 phosphorylation of c-Raf and subsequent downstream signaling . Positive_regulation EPHB2 AKT1 21263216 2387577 Altogether , our results show that low levels of DSBs trigger ATM- and *dependent* [ERK] pro-survival signaling and increased cell proliferation whereas higher levels result in ERK dephosphorylation consistent with a dose dependent switch from pro-survival to anti-survival signaling . Positive_regulation EPHB2 AKT1 21903772 2511208 inhibition in APC ( - ) /Pten ( - ) tumor cells *resulted* in compensatory upregulation of [ERK] signaling . Positive_regulation EPHB2 AKT1 21943646 2492386 Here , we show that the effect of plasma membrane cholesterol depletion on the inhibition of activation *allows* sustained [ERK] activation and the subsequent upregulation of IL-8 expression . Positive_regulation EPHB2 AKT1 22509106 2584046 Furthermore , NGF affected cell cycle progression of HCECs by regulating cyclin D through and [Erk] *activation* upon treatment with the pathway inhibitors , LY294002 for Akt or PD98059 for Erk pathways . Positive_regulation EPHB2 AKT1 22649371 2522751 Although blockade of the ERK pathway had no effect on the activation of Akt , inhibition of partially *prevented* activation of [ERK] , suggesting cross-talk between the ERK and PI3K-Akt pathways . Positive_regulation EPHB2 AKT1 22814678 2645888 Additionally , BA could also down-regulate VEGF secretion in A549 cancer cells , which may correlate with the suppression of [ERK] , *activation* , indicating that BA inhibits tumor angiogenesis and tumor growth through VEGFR2 signaling pathways . Positive_regulation EPHB2 AKT1 23087613 2690467 When analyzing possible signaling mechanisms we found that extracellular signal regulated kinase ( ERK ) and are activated by C3 ( bot ) and [ERK] is *induced* by the C3 ( E174Q ) mutant . Positive_regulation EPHB2 AKT1 23276632 2775370 Furthermore , E2 rapidly enhanced [ERK] and Akt activation in cortical neurons , and inhibitors of ERK and activation significantly *attenuated* E2 induction of excitatory glutamatergic synapses . Positive_regulation EPHB2 AKT1 23701950 2806131 In contrast , activity was *sufficient* to induce not only B-Raf phosphorylation but also [MEK/ERK] activation in the hormone refractory LNCaP variant , C4-2 . Positive_regulation EPHB2 AKT1 23817184 2815742 The results of the present study show that [ERK] could be *activated* by PI3 kinase , PDK1 , , and Rac1 and that alternatively , Akt and Rac1 could be activated by MEK and ERK in MSTO-211H cells . Positive_regulation EPHB2 AKT1 24012959 2845955 nherf1 Mutations ( K172N and D301V ) caused complete or partial loss of NHERF1 functions by affecting the PTEN/NHERF1/PDGFRß complex formation , inactivating NHERF1 inhibition of PDGF induced and [ERK] *activation* , and attenuating the tumor-suppressor effects of NHERF1-wt . Positive_regulation EPHB2 AKT1 24212072 2891947 Our results seem that inhibition of and *activation* of [phospho-ERK] or p38 MAPK may lead to the suppression of melanogenesis in eupafolin treated B16F10 mouse melanoma cells . Positive_regulation EPHB2 AKT1 24239652 2897698 Specifically , HA-induced NF-?B activation was mediated by ROS and , and that HA-induced AP-1 activation was *mediated* by JNK and [ERK] . Positive_regulation EPHB2 AKT1 24345501 2880890 TNF-a stimulated significantly phosphorylation on Ser536 of NF-?B/p65 , Ser473 of at 5-15 min , and *activations* of IKK-ß and [ERK] at 15-30 min. Diosgenin ( 1 µmol · Positive_regulation EPHB2 AKT1 24424889 2901244 Taken together , these findings suggest that MHY-449 induces apoptosis via downregulation of the and *activation* of [ERK] in androgen independent , p53-null and PTEN negative PC3 human prostate cancer cells . Positive_regulation EPHB2 AKT1 24530412 2924273 It is noteworthy that a tyrosine kinase receptor inhibitor , K252a , an MEK-ERK inhibitor ( U0126 ) , and a inhibitor ( LY294002 ) remarkably *attenuated* TrkB , [ERK] , and Akt phosphorylation as well as increase of OPN mRNA expression in the HCEM cells , respectively . Positive_regulation EPHB2 AKT1 24597762 2933795 Exposure of CGNs to GDF15 markedly induced the phosphorylation of [ERK] ( extracellular-signal regulated kinase ) , Akt and mTOR ( mammalian target of rapamycin ) , but the GDF15 induced IK densities and increased expression of Kv2.1 were *attenuated* only by and mTOR , and not ERK , inhibitors . Positive_regulation EPHB2 AKT1 24909280 2941798 in the LY294002 treatment group , the level of protein decreased and [p-ERK] *increased* ; Positive_regulation EPHB2 AKT2 10910095 713902 Perhaps surprisingly , activation of M+ : ER* or expression of a constitutively active form of Akt *led* to rapid activation of MAP/ERK Kinase (MEK) and the extracellular signal regulated kinase ( [ERK] ) /mitogen activated protein ( MAP ) kinases in Rat1 cells . Positive_regulation EPHB2 AKT2 11454948 837874 Inhibition of activation *required* almost complete inhibition of [ERK] . Positive_regulation EPHB2 AKT2 12034359 948251 C ( 2 ) -ceramide induced a delayed activation of [ERK] ( > 1 h ) and a much later *activation* of ( > 3 h ) in human melanocytes . Positive_regulation EPHB2 AKT2 12138095 991537 Cell survival relied on two pertussis toxin-sensitive events , activation of [ERK] and *activation* of phosphatidylinositol 3-kinase <(PI3K)/Akt> by S1P . Positive_regulation EPHB2 AKT2 12670507 1076118 Interestingly , the suppression of [ERK-MAP] kinase activation in Csk ( - ) /Csk cells was *restored* by overexpression of a dominant negative . Positive_regulation EPHB2 AKT2 12704651 1082372 Moreover , 15dPGJ ( 2 ) did not induce activation of or *activation* of extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 AKT2 14973553 1212486 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both ERK/MAPK and signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 AKT2 15242975 1282055 when PI3K was inhibited , [ERK] phosphorylation could be *induced* by microinjected activated , indicating important cross-talk between the PI3K and ERK1/2 pathways . Positive_regulation EPHB2 AKT2 15337530 1291369 We have characterized the *role* of Drosophila PI3K and in [ERK] pathway activation involving insulin induced proliferation using Drosophila Schneider cells . Positive_regulation EPHB2 AKT2 15607817 1357023 Furthermore , U0126 and LY294002 , which respectively inhibit MEK *induced* [ERK] phosphorylation and PI3 kinase mediated phosphorylation had distinct effects on C3a induced responses . Positive_regulation EPHB2 AKT2 16954211 1633345 Under basal conditions , dopamine transporter knock-out mice show enhanced striatal DARPP-32 phosphorylation , *activation* of [ERK] , and inactivation of as compared with wild-type littermates . Positive_regulation EPHB2 AKT2 16984917 1640519 These results suggest that expression of a splice variant of CD99 contributes to the invasive ability of human breast cancer cells by up-regulating AP-1 mediated gene expression through the *dependent* [ERK] and JNK signaling pathways . Positive_regulation EPHB2 AKT2 18310510 1904178 HG induces phosphoinositide 3- kinase [ PI3K ; inhibited by adenoviral ( Ad ) .dominant negative ( dn ) PI3Kp85 ] , Akt ( inhibited by Ad.dnAkt1 ) , and [ERK] ( inhibited by PD-98059 ) activation and *induces* IL-17 expression via PI3K -- > -- > ERK dependent signaling . Positive_regulation EPHB2 AKT2 18506372 1917984 ERK and inhibitors *inhibit* ECM induced [ERK] , AKT activation and cell proliferation . Positive_regulation EPHB2 AKT2 18509361 1971897 In a univariate analysis , shorter overall survival was associated with the presence of ulceration ( P=0.001 ) and BRAF exon 15 mutations ( P=0.005 ) as well as the absence of nuclear activation of ( P=0.022 ) and of cytoplasmic *activation* of [ERK] ( P=0.003 ) . Positive_regulation EPHB2 AKT2 18799725 1986898 Here , we report that mice lacking the transcription factor forkhead box O3a (FoxO3a) develop neutrophilia associated with inhibition of the up-regulation of negative regulator of cell proliferation , Sprouty related Ena/VASP homology 1 domain containing proteins 2 ( Spred2 ) and and [ERK] *activation* , in HSCs during hematopoietic recovery following myelosuppressive stress conditions . Positive_regulation EPHB2 AKT2 19186178 2054105 Interestingly , activation of signaling *had* differential effects on [ERK] and p38 activation . Positive_regulation EPHB2 AKT2 19191907 2127879 The studies with pharmacological inhibitors suggest that calpain inhibition mediated monocyte migration is *mediated* by activation of [ERK] , p38 , JNK , and Rac . Positive_regulation EPHB2 AKT2 19424594 2076402 Here , we showed that long-term ER stress resulted in inactivation of and *activation* of [ERK] in human hepatocellular carcinoma ( HCC ) cells . Positive_regulation EPHB2 AKT2 20177738 2272385 These observations indicate that Cbl-b promotes RBL-2H3 apoptosis induced by VP-16 or Ara-c , probably through inhibition of and *activation* of [ERK] . Positive_regulation EPHB2 AKT2 20207017 2237089 Neutrophil infiltration , ICAM , TNF-alpha and iNOS mRNA expression , neuronal apoptosis and the expression of p-JNK , pSTAT1 and [p-Erk] were reduced and *increased* on C5aR inhibition in MRL/lpr brains . Positive_regulation EPHB2 AKT2 20561929 2290087 The vasoprotective effect of JP05 through the activation of *dependent* eNOS and [MEK/ERK] pathways in brain endothelial cells . Positive_regulation EPHB2 AKT2 21263216 2387578 Altogether , our results show that low levels of DSBs trigger ATM- and *dependent* [ERK] pro-survival signaling and increased cell proliferation whereas higher levels result in ERK dephosphorylation consistent with a dose dependent switch from pro-survival to anti-survival signaling . Positive_regulation EPHB2 AKT2 21903772 2511209 inhibition in APC ( - ) /Pten ( - ) tumor cells *resulted* in compensatory upregulation of [ERK] signaling . Positive_regulation EPHB2 AKT2 21943646 2492387 Here , we show that the effect of plasma membrane cholesterol depletion on the inhibition of activation *allows* sustained [ERK] activation and the subsequent upregulation of IL-8 expression . Positive_regulation EPHB2 AKT2 22509106 2584047 Furthermore , NGF affected cell cycle progression of HCECs by regulating cyclin D through and [Erk] *activation* upon treatment with the pathway inhibitors , LY294002 for Akt or PD98059 for Erk pathways . Positive_regulation EPHB2 AKT2 22649371 2522752 Although blockade of the ERK pathway had no effect on the activation of Akt , inhibition of partially *prevented* activation of [ERK] , suggesting cross-talk between the ERK and PI3K-Akt pathways . Positive_regulation EPHB2 AKT2 22814678 2645889 Additionally , BA could also down-regulate VEGF secretion in A549 cancer cells , which may correlate with the suppression of [ERK] , *activation* , indicating that BA inhibits tumor angiogenesis and tumor growth through VEGFR2 signaling pathways . Positive_regulation EPHB2 AKT2 23087613 2690468 When analyzing possible signaling mechanisms we found that extracellular signal regulated kinase ( ERK ) and are activated by C3 ( bot ) and [ERK] is *induced* by the C3 ( E174Q ) mutant . Positive_regulation EPHB2 AKT2 23276632 2775371 Furthermore , E2 rapidly enhanced [ERK] and Akt activation in cortical neurons , and inhibitors of ERK and activation significantly *attenuated* E2 induction of excitatory glutamatergic synapses . Positive_regulation EPHB2 AKT2 23701950 2806132 In contrast , activity was *sufficient* to induce not only B-Raf phosphorylation but also [MEK/ERK] activation in the hormone refractory LNCaP variant , C4-2 . Positive_regulation EPHB2 AKT2 23812423 2937893 Based on quantitative bioimaging and molecular markers for genetic and signaling aberrations , we showed that the induced expression of oncogenic Kras during early development led to liver enlargement and hepatocyte proliferation , associated with elevated [Erk] phosphorylation , *activation* of and modulation of its two downstream targets , p21Cip and S6 kinase . Positive_regulation EPHB2 AKT2 23817184 2815743 The results of the present study show that [ERK] could be *activated* by PI3 kinase , PDK1 , , and Rac1 and that alternatively , Akt and Rac1 could be activated by MEK and ERK in MSTO-211H cells . Positive_regulation EPHB2 AKT2 24012959 2845956 nherf1 Mutations ( K172N and D301V ) caused complete or partial loss of NHERF1 functions by affecting the PTEN/NHERF1/PDGFRß complex formation , inactivating NHERF1 inhibition of PDGF induced and [ERK] *activation* , and attenuating the tumor-suppressor effects of NHERF1-wt . Positive_regulation EPHB2 AKT2 24212072 2891948 Our results seem that inhibition of and *activation* of [phospho-ERK] or p38 MAPK may lead to the suppression of melanogenesis in eupafolin treated B16F10 mouse melanoma cells . Positive_regulation EPHB2 AKT2 24239652 2897699 Specifically , HA-induced NF-?B activation was mediated by ROS and , and that HA-induced AP-1 activation was *mediated* by JNK and [ERK] . Positive_regulation EPHB2 AKT2 24345501 2880891 TNF-a stimulated significantly phosphorylation on Ser536 of NF-?B/p65 , Ser473 of at 5-15 min , and *activations* of IKK-ß and [ERK] at 15-30 min. Diosgenin ( 1 µmol · Positive_regulation EPHB2 AKT2 24424889 2901245 Taken together , these findings suggest that MHY-449 induces apoptosis via downregulation of the and *activation* of [ERK] in androgen independent , p53-null and PTEN negative PC3 human prostate cancer cells . Positive_regulation EPHB2 AKT2 24530412 2924274 It is noteworthy that a tyrosine kinase receptor inhibitor , K252a , an MEK-ERK inhibitor ( U0126 ) , and a inhibitor ( LY294002 ) remarkably *attenuated* TrkB , [ERK] , and Akt phosphorylation as well as increase of OPN mRNA expression in the HCEM cells , respectively . Positive_regulation EPHB2 AKT2 24597762 2933796 Exposure of CGNs to GDF15 markedly induced the phosphorylation of [ERK] ( extracellular-signal regulated kinase ) , Akt and mTOR ( mammalian target of rapamycin ) , but the GDF15 induced IK densities and increased expression of Kv2.1 were *attenuated* only by and mTOR , and not ERK , inhibitors . Positive_regulation EPHB2 AKT2 24909280 2941799 in the LY294002 treatment group , the level of protein decreased and [p-ERK] *increased* ; Positive_regulation EPHB2 AKT3 10910095 713903 Perhaps surprisingly , activation of M+ : ER* or expression of a constitutively active form of Akt *led* to rapid activation of [MAP/ERK Kinase (MEK)] and the extracellular signal regulated kinase ( ERK ) /mitogen activated protein ( MAP ) kinases in Rat1 cells . Positive_regulation EPHB2 AKT3 11454948 837875 Inhibition of activation *required* almost complete inhibition of [ERK] . Positive_regulation EPHB2 AKT3 12034359 948252 C ( 2 ) -ceramide induced a delayed activation of [ERK] ( > 1 h ) and a much later *activation* of ( > 3 h ) in human melanocytes . Positive_regulation EPHB2 AKT3 12138095 991538 Cell survival relied on two pertussis toxin-sensitive events , *activation* of [ERK] and activation of phosphatidylinositol 3-kinase <(PI3K)/Akt> by S1P . Positive_regulation EPHB2 AKT3 12670507 1076119 Interestingly , the suppression of [ERK-MAP] kinase activation in Csk ( - ) /Csk cells was *restored* by overexpression of a dominant negative . Positive_regulation EPHB2 AKT3 12704651 1082373 Moreover , 15dPGJ ( 2 ) did not induce activation of or *activation* of extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 AKT3 14973553 1212487 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both ERK/MAPK and signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 AKT3 15242975 1282056 when PI3K was inhibited , [ERK] phosphorylation could be *induced* by microinjected activated , indicating important cross-talk between the PI3K and ERK1/2 pathways . Positive_regulation EPHB2 AKT3 15337530 1291370 We have characterized the *role* of Drosophila PI3K and in [ERK] pathway activation involving insulin induced proliferation using Drosophila Schneider cells . Positive_regulation EPHB2 AKT3 15607817 1357024 Furthermore , U0126 and LY294002 , which respectively inhibit MEK *induced* [ERK] phosphorylation and PI3 kinase mediated phosphorylation had distinct effects on C3a induced responses . Positive_regulation EPHB2 AKT3 16954211 1633346 Under basal conditions , dopamine transporter knock-out mice show enhanced striatal DARPP-32 phosphorylation , *activation* of [ERK] , and inactivation of as compared with wild-type littermates . Positive_regulation EPHB2 AKT3 16984917 1640520 These results suggest that expression of a splice variant of CD99 contributes to the invasive ability of human breast cancer cells by up-regulating AP-1 mediated gene expression through the *dependent* [ERK] and JNK signaling pathways . Positive_regulation EPHB2 AKT3 18310510 1904179 HG induces phosphoinositide 3- kinase [ PI3K ; inhibited by adenoviral ( Ad ) .dominant negative ( dn ) PI3Kp85 ] , Akt ( inhibited by Ad.dnAkt1 ) , and [ERK] ( inhibited by PD-98059 ) activation and *induces* IL-17 expression via PI3K -- > -- > ERK dependent signaling . Positive_regulation EPHB2 AKT3 18506372 1917985 ERK and inhibitors *inhibit* ECM induced [ERK] , AKT activation and cell proliferation . Positive_regulation EPHB2 AKT3 18509361 1971898 In a univariate analysis , shorter overall survival was associated with the presence of ulceration ( P=0.001 ) and BRAF exon 15 mutations ( P=0.005 ) as well as the absence of nuclear activation of ( P=0.022 ) and of cytoplasmic *activation* of [ERK] ( P=0.003 ) . Positive_regulation EPHB2 AKT3 18799725 1986899 Here , we report that mice lacking the transcription factor forkhead box O3a (FoxO3a) develop neutrophilia associated with inhibition of the up-regulation of negative regulator of cell proliferation , Sprouty related Ena/VASP homology 1 domain containing proteins 2 ( Spred2 ) and and [ERK] *activation* , in HSCs during hematopoietic recovery following myelosuppressive stress conditions . Positive_regulation EPHB2 AKT3 19186178 2054106 Interestingly , activation of signaling *had* differential effects on [ERK] and p38 activation . Positive_regulation EPHB2 AKT3 19191907 2127880 The studies with pharmacological inhibitors suggest that calpain inhibition mediated monocyte migration is *mediated* by activation of [ERK] , p38 , JNK , and Rac . Positive_regulation EPHB2 AKT3 19424594 2076403 Here , we showed that long-term ER stress resulted in inactivation of and *activation* of [ERK] in human hepatocellular carcinoma ( HCC ) cells . Positive_regulation EPHB2 AKT3 20177738 2272386 These observations indicate that Cbl-b promotes RBL-2H3 apoptosis induced by VP-16 or Ara-c , probably through inhibition of and *activation* of [ERK] . Positive_regulation EPHB2 AKT3 20207017 2237090 Neutrophil infiltration , ICAM , TNF-alpha and iNOS mRNA expression , neuronal apoptosis and the expression of p-JNK , pSTAT1 and [p-Erk] were reduced and *increased* on C5aR inhibition in MRL/lpr brains . Positive_regulation EPHB2 AKT3 20561929 2290088 The vasoprotective effect of JP05 through the activation of *dependent* eNOS and [MEK/ERK] pathways in brain endothelial cells . Positive_regulation EPHB2 AKT3 21263216 2387579 Altogether , our results show that low levels of DSBs trigger ATM- and *dependent* [ERK] pro-survival signaling and increased cell proliferation whereas higher levels result in ERK dephosphorylation consistent with a dose dependent switch from pro-survival to anti-survival signaling . Positive_regulation EPHB2 AKT3 21903772 2511210 inhibition in APC ( - ) /Pten ( - ) tumor cells *resulted* in compensatory upregulation of [ERK] signaling . Positive_regulation EPHB2 AKT3 21943646 2492388 Here , we show that the effect of plasma membrane cholesterol depletion on the inhibition of activation *allows* sustained [ERK] activation and the subsequent upregulation of IL-8 expression . Positive_regulation EPHB2 AKT3 22509106 2584048 Furthermore , NGF affected cell cycle progression of HCECs by regulating cyclin D through and [Erk] *activation* upon treatment with the pathway inhibitors , LY294002 for Akt or PD98059 for Erk pathways . Positive_regulation EPHB2 AKT3 22649371 2522753 Although blockade of the ERK pathway had no effect on the activation of Akt , inhibition of partially *prevented* activation of [ERK] , suggesting cross-talk between the ERK and PI3K-Akt pathways . Positive_regulation EPHB2 AKT3 22814678 2645890 Additionally , BA could also down-regulate VEGF secretion in A549 cancer cells , which may correlate with the suppression of [ERK] , *activation* , indicating that BA inhibits tumor angiogenesis and tumor growth through VEGFR2 signaling pathways . Positive_regulation EPHB2 AKT3 23087613 2690469 When analyzing possible signaling mechanisms we found that extracellular signal regulated kinase ( ERK ) and are activated by C3 ( bot ) and [ERK] is *induced* by the C3 ( E174Q ) mutant . Positive_regulation EPHB2 AKT3 23276632 2775372 Furthermore , E2 rapidly enhanced [ERK] and Akt activation in cortical neurons , and inhibitors of ERK and activation significantly *attenuated* E2 induction of excitatory glutamatergic synapses . Positive_regulation EPHB2 AKT3 23701950 2806133 In contrast , activity was *sufficient* to induce not only B-Raf phosphorylation but also [MEK/ERK] activation in the hormone refractory LNCaP variant , C4-2 . Positive_regulation EPHB2 AKT3 23817184 2815744 The results of the present study show that [ERK] could be *activated* by PI3 kinase , PDK1 , , and Rac1 and that alternatively , Akt and Rac1 could be activated by MEK and ERK in MSTO-211H cells . Positive_regulation EPHB2 AKT3 24012959 2845957 nherf1 Mutations ( K172N and D301V ) caused complete or partial loss of NHERF1 functions by affecting the PTEN/NHERF1/PDGFRß complex formation , inactivating NHERF1 inhibition of PDGF induced and [ERK] *activation* , and attenuating the tumor-suppressor effects of NHERF1-wt . Positive_regulation EPHB2 AKT3 24212072 2891949 Our results seem that inhibition of and *activation* of [phospho-ERK] or p38 MAPK may lead to the suppression of melanogenesis in eupafolin treated B16F10 mouse melanoma cells . Positive_regulation EPHB2 AKT3 24239652 2897700 Specifically , HA-induced NF-?B activation was mediated by ROS and , and that HA-induced AP-1 activation was *mediated* by JNK and [ERK] . Positive_regulation EPHB2 AKT3 24345501 2880892 TNF-a stimulated significantly phosphorylation on Ser536 of NF-?B/p65 , Ser473 of at 5-15 min , and *activations* of IKK-ß and [ERK] at 15-30 min. Diosgenin ( 1 µmol · Positive_regulation EPHB2 AKT3 24424889 2901246 Taken together , these findings suggest that MHY-449 induces apoptosis via downregulation of the and *activation* of [ERK] in androgen independent , p53-null and PTEN negative PC3 human prostate cancer cells . Positive_regulation EPHB2 AKT3 24530412 2924275 It is noteworthy that a tyrosine kinase receptor inhibitor , K252a , an MEK-ERK inhibitor ( U0126 ) , and a inhibitor ( LY294002 ) remarkably *attenuated* TrkB , [ERK] , and Akt phosphorylation as well as increase of OPN mRNA expression in the HCEM cells , respectively . Positive_regulation EPHB2 AKT3 24597762 2933797 Exposure of CGNs to GDF15 markedly induced the phosphorylation of [ERK] ( extracellular-signal regulated kinase ) , Akt and mTOR ( mammalian target of rapamycin ) , but the GDF15 induced IK densities and increased expression of Kv2.1 were *attenuated* only by and mTOR , and not ERK , inhibitors . Positive_regulation EPHB2 AKT3 24909280 2941800 in the LY294002 treatment group , the level of protein decreased and [p-ERK] *increased* ; Positive_regulation EPHB2 AKTIP 16154539 1461332 The aim of this study was to examine the effect of cisplatin on [ERK] *activation* in the rat kidney and also the effect of on cisplatin induced nephrotoxicity in rats . Positive_regulation EPHB2 AKTIP 22771629 2639570 *induces* the activation of PI3K/AKT and [Raf/MEK/ERK] signaling pathways . Positive_regulation EPHB2 ALB 10677388 668111 In addition , recombinant human *activated* [ERK] in a time dependent ( maximal after 5 min ) and dose dependent ( maximal at 1 mg/ml ) fashion . Positive_regulation EPHB2 ALB 11341772 812542 [ERK] *mediates* effects of glycated in mesangial cells . Positive_regulation EPHB2 ALK 16909118 1692143 The induced [MEK/ERK] *activation* is independent of c-Raf as evidenced by the lack of MEK1/2 and ERK1/2 phosphorylation upon c-Raf inactivation by two different inhibitors , RI and ZM336372 , and by its siRNA mediated depletion . Positive_regulation EPHB2 ALK 21415216 2416607 Forced expression of *induced* marked activation of extracellular signal regulated kinase ( [ERK] ) and STAT3 , but not that of AKT . Positive_regulation EPHB2 AMOTL2 21937427 2507025 *promotes* [MAPK/ERK] activation via c-Src , which is dependent on phosphorylation of tyrosine residue at position 103 but independent of the C-terminal PDZ binding domain . Positive_regulation EPHB2 ANG 11549292 856802 PD98059 -- a specific inhibitor of MAP or Erk kinase 1 (MEK 1) , the upstream kinase that phosphorylates Erk1/2 -- abolishes *induced* [Erk] phosphorylation and cell proliferation without affecting nuclear translocation of angiogenin . Positive_regulation EPHB2 ANG 14600156 1187508 and 5-hydroxytryptamine ( 5-HT ) *stimulated* both [ERK] and NHE-1 activities , with activation of NHE-1 preceding that of ERK . Positive_regulation EPHB2 ANGPT1 12890486 1117274 Localization of Tie2 and phospholipase D in endothelial caveolae is involved in *induced* [MEK/ERK] phosphorylation and migration in endothelial cells . Positive_regulation EPHB2 ANGPT1 12890486 1117399 Ang1 induced MEK/ERK activation was abrogated when PLD was inhibited , suggesting that PLD mediates *induced* [MEK/ERK] activation . Positive_regulation EPHB2 ANGPT1 14978510 1213583 We further show that NLLMAAS specifically suppresses both *induced* [ERK] activity and migration in human umbilical endothelial cells . Positive_regulation EPHB2 ANGPT2 10406835 629631 In this study , we examined the role of extracellular signal regulated kinase ( ERK ) in Ang II-mediated TGF-beta(1) expression in VSMCs and the *role* of in aortic [ERK] activity of stroke-prone spontaneously hypertensive rats . Positive_regulation EPHB2 ANGPT2 10506481 649282 In adult rat VSMCs , *activates* [ERK] and JNK , but weakly induces Egr-1 , a transcription factor implicated in PDGF-B chain gene expression , compared with newborn VSMCs . Positive_regulation EPHB2 ANGPT2 10788453 688713 ConA induced proteolytic cleavage of the epidermal growth factor (EGF) receptor at carboxyl terminus and abolished Ang II-induced transactivation of the EGF receptor , which is critical for [ERK] *activation* by in VSMC . Positive_regulation EPHB2 ANGPT2 10891597 711260 While *induced* an initial activation of [ERK] in quiescent cells , the NGF mediated plateau of ERK-stimulation was lowered by costimulation with ANG II . Positive_regulation EPHB2 ANGPT2 10988260 732590 In addition , induced a rapid ( 5 minutes ) *increase* of the [MAPK/ERK] activity that was accompanied by increased expression ( 3-fold ) of the c-fos proto-oncogene . Positive_regulation EPHB2 ANGPT2 11162642 782343 Here we found that an antioxidant , N-acetylcysteine , inhibited [ERK] activation and EGF receptor tyrosine phosphorylation *induced* by . Positive_regulation EPHB2 ANGPT2 11230986 789429 *increased* [ERK] phosphorylation , which was inhibited by addition of the AT1 receptor-specific antagonist CV11974 , but enhanced by addition of the AT2 receptor-specific antagonist PD123319 , suggesting that activation of AT2 receptor attenuated the AT1 receptor mediated ERK phosphorylation . Positive_regulation EPHB2 ANGPT2 11562426 862798 Our findings showed that *stimulated* rapid and significant activation of extracellular signal regulated kinase ( [ERK] ) 1/2 , c-Jun N-terminal kinase (JNK) , and p38 in RASMC . Positive_regulation EPHB2 ANGPT2 11566906 863964 Maximal [ERK] activity *induced* by was increased 1.9- and 2.2-fold by AT(2) inhibition , which was abolished by orthovanadate but not okadaic acid or pertussis toxin . Positive_regulation EPHB2 ANGPT2 11597988 870333 , as well as exogenous H ( 2 ) O ( 2 ) , *activated* [ERK] , p38 MAPK , and JNK , which were significantly inhibited by N-acetylcysteine and DPI . Positive_regulation EPHB2 ANGPT2 11875120 918884 In COS-7 cells transiently expressing the rat AT1A-R , also *caused* [ERK] activation through EGF-R transactivation . Positive_regulation EPHB2 ANGPT2 11967827 767286 *increased* [ERK] and p38 activities in human cardiomyocytes . Positive_regulation EPHB2 ANGPT2 12186792 978310 *requires* EGFR to mediate [ERK] activation in VSMCs and the heart . Positive_regulation EPHB2 ANGPT2 12384488 998804 [ERK] phosphorylation ( measured by immunoblot analysis ) during intracellular acidification was *increased* by , an effect that was abolished by losartan and U-0126 . Positive_regulation EPHB2 ANGPT2 12450322 1018699 In summary , in H295R cells , *activated* [ERK] and p38 MAPKs , ANG II-induced p38 MAPK was mediated by 12-LO activation , and ANG II-induced aldosterone synthesis was prevented by 12-LO- and p38 MAPK-specific inhibitors . Positive_regulation EPHB2 ANGPT2 12620889 1091869 *stimulates* PKC dependent [ERK] activation , DNA synthesis , and cell division in intestinal epithelial cells . Positive_regulation EPHB2 ANGPT2 12620889 1091870 To investigate the effects of receptor mediated PKC activation on mitogenesis , we demonstrated that *induced* [ERK] activation , a response completely blocked by pretreatment with mitogen/extracellular signal regulated kinase inhibitors or specific PKC inhibitors . Positive_regulation EPHB2 ANGPT2 14600156 1187523 EGF receptor blockade attenuated [ERK] activation , but not NHE-1 *activation* by 5-HT and , suggesting that the EGF receptor and NHE-1 work in parallel to stimulate ERK activity in RASM cells , converging distal to the EGF receptor but at or above the level of Ras in the Ras-MEK-ERK pathway . Positive_regulation EPHB2 ANGPT2 14730207 1198858 Furthermore , E ( 2 ) and antioxidants , such as N-acetyl cysteine and diphenylene iodonium , decreased *induced* cell proliferation , ET-1 promoter activity , ET-1 mRNA , [ERK] phosphorylation , and activator protein-1 mediated reporter activity . Positive_regulation EPHB2 ANGPT2 15894894 1407875 An immediate activation of both [ERK] and p38 MAP-kinase and of cPLA2 was *induced* by in human neutrophils . Positive_regulation EPHB2 ANGPT2 16461377 1567548 TG and *induced* phosphorylation of [ERK] , which was sensitive to 2-APB and was selectively required for CRE binding protein phosphorylation . Positive_regulation EPHB2 ANGPT2 16522324 1567940 The transactivation of EGF receptor *resulted* in activation of extracellular signal regulated kinase ( [ERK] ) that was also inhibited by valsartan , and enhanced by PD123319 . Positive_regulation EPHB2 ANGPT2 16554661 1574663 The signaling pathways linked to *dependent* [ERK] activation were determined in an immortalized mouse podocyte cell line by monitoring ANG2 stimulated phosphorylation of ERK1/2 . Positive_regulation EPHB2 ANGPT2 16554661 1574665 *induced* transient [ERK] phosphorylation that was maximal at 5 min and then rapidly dissipated . Positive_regulation EPHB2 ANGPT2 16554661 1574666 *dependent* [ERK] activation was inhibited by : ( 1 ) the type-1 ANG2-selective antagonist losartan ; Positive_regulation EPHB2 ANGPT2 16554661 1574668 *dependent* [ERK] activation was mediated by both protein kinase C ( PKC ) - and calcium dependent mechanisms and was associated with tyrosine phosphorylation of EGFR . Positive_regulation EPHB2 ANGPT2 16554661 1574672 In contrast , *had* no effect on [ERK] phosphorylation in stably transfected HEK293 cells . Positive_regulation EPHB2 ANGPT2 16554661 1574676 These data indicate that [ERK] activation is *induced* by in podocytes by mechanisms involving ANG2 dependent release of HB-EGF which , in turn , may act in an autocrine and paracrine fashion to stimulate ERK activity . Positive_regulation EPHB2 ANGPT2 17441313 1729608 In VSMC , stimulation *increased* the phosphorylation of [ERK] , which reached the peak around 60 minutes . Positive_regulation EPHB2 ANGPT2 18094367 1862650 We conclude that *activates* [ERK] and cPLA2alpha in a concentration dependent manner via AT1 , and that the balance between ERK and cPLA2alpha activities determines the ultimate response to Ang II in intact proximal tubules . Positive_regulation EPHB2 ANGPT2 19429670 2106852 and TNF-alpha clearly *enhanced* [ERK] and p38MAPK phosphorylation . Positive_regulation EPHB2 ANGPT2 19646989 2143213 We also determined the phosphorylation of ERK during the first min of acidosis and we detected that significantly *enhanced* the [ERK] phosphorylation levels , an effect that was cancelled by scavenging ROS with MPG . Positive_regulation EPHB2 ANGPT2 23691054 2785649 Furthermore , *stimulated* [ERK] and Akt phosphorylation in NSCs . Positive_regulation EPHB2 ANGPT2 9564040 500707 In PKC depleted cells , increased Ras-GTP level and *activated* Raf and [ERK] in a Ras dependent manner . Positive_regulation EPHB2 ANGPT2 9564040 500724 In summary , can *activate* [ERK] via two pathways ; Positive_regulation EPHB2 ANGPT2 9724295 529407 *caused* no detectable increase in [ERK] activity or in c-fos mRNA abundance in ARVM but increased ERK activity within 5 min in CMEC and increased c-fos mRNA levels . Positive_regulation EPHB2 ANGPT2 9774361 539717 Calmodulin inhibitors ( W7 and calmidazolium ) and tyrosine kinase inhibitors ( genistein and ST638 ) completely blocked [ERK] *activation* by and A23187 . Positive_regulation EPHB2 ANGPT2 9933031 589202 On the other hand , an obligatory tyrosine phosphorylation step for activation of ERK was indicated by the use of protein tyrosine kinase inhibitors , which profoundly inhibited the *activation* of [ERK] by EGF , , and PMA . Positive_regulation EPHB2 ANXA1 16278303 1525864 Ac2-26 binding led to ERK activation in both FPR- and FPRL-1/ALX transfected cells , while *caused* [ERK] activation only in cells transfected with FPRL-1/ALX . Positive_regulation EPHB2 ANXA6 11157888 780937 Inhibition of PI <3-K/p70> ( S6K ) activities also unexpectedly *inhibited* [ERK] activity , whereas the converse was not observed , suggesting that PI 3-K acted upstream from ERK and controlled this pathway for CEC proliferation . Positive_regulation EPHB2 APC 16478791 1528390 The GTP loading and the protein level of mutated RAS were decreased in cells with reduced ERK activity as a result of APC overexpression , indicating that *regulates* RAS induced [ERK] activation at least partly by reduction of the RAS protein level . Positive_regulation EPHB2 APC 19891966 2197339 Intracellularly , *activates* [ERK] , Akt , and NFkappaB , but not the JNK pathway to promote MDA-MB-231 cell motility . Positive_regulation EPHB2 APLN 20495838 2333979 Suppression of APJ with siRNA abolished the *induced* activation of [ERK] and Akt . Positive_regulation EPHB2 APLN 21437254 2406520 APJ protein was detected in CVSMCs , and *activated* [ERK] and AKT ( a downstream effector of PI3-K ) . Positive_regulation EPHB2 APLN 21437254 2406524 Suppression of APJ with siRNA abolished the induced *activation* of [ERK] and Akt . Positive_regulation EPHB2 APLN 22200678 2558745 The siRNA knockdown of either APJ or KOR receptor in human umbilical vein endothelial cells ( HUVECs ) resulted in significant reduction of the *induced* [ERK] activation . Positive_regulation EPHB2 APLN 24227918 2868665 Pretreatment with LY294002 and PD98059 abolished induced *activation* of Akt and [Erk] , proliferation , and collagen I expression . Positive_regulation EPHB2 APOB 11509543 848325 Treatment of VSMC with the intracellular Ca ( 2+ ) chelator EGTA-AM ( 50 micromol/l ) significantly increased [ERK] phosphorylation *induced* by native and mildly modified , whereas chelation of extracellular Ca ( 2+ ) by EGTA ( 3 mmol/l ) significantly reduced LDL induced ERK phosphorylation . Positive_regulation EPHB2 APOB 11509543 848326 Downregulation of PKC with phorbol myristate acetate ( 5 micromol/l ) markedly reduced *induced* [ERK] phosphorylation . Positive_regulation EPHB2 APOB 15262179 1274625 Since we recently demonstrated that high-density *induced* human coronary artery endothelial cell ( HCEC ) tube formation through [Ras/Raf/ERK] ( extracellular-signal regulated kinase ) activation [ Arterioscler . Positive_regulation EPHB2 APOB 15750341 1379863 ERK phosphorylation was not affected by exposure to the Ca2+ chelator BAPTA-AM but inhibition of protein kinase C ( PKC ) with GF109203X , inhibition of Src kinase with PP1 ( 5 microM ) and inhibition of phospholipase C (PLC) with U73122/U73343 ( 5 microM ) all reduced [ERK] phosphorylation in *response* to glycated . Positive_regulation EPHB2 APOB 15750341 1379868 These findings indicate that [ERK] phosphorylation in *response* to glycated involves the activation of PKC , PLC , and MEK , but is independent of intracellular Ca2+ . Positive_regulation EPHB2 APOB 17002919 1618167 This study examines whether an interaction exists between *induced* TGF-beta/Smad signaling pathways and [ERK] activation leading to PAI-1 transcription in human mesangial cells . Positive_regulation EPHB2 APOB 17002919 1618168 ( 50 microg/mL ) *induced* an acute increase in [ERK] activity within 15 min , which decreased to control value at 2 h. Incubation with anti-TGF-beta or SB-431542 , an inhibitor of the TGF-beta type I receptor , along with Ox-LDL , inhibited the expected increase in ERK phosphorylation . Positive_regulation EPHB2 APOB 17002919 1618173 These results suggest that phosphorylation of [ERK] is *induced* by through the induction of the TGF-beta signaling pathway and that activated ERK , in turn , participates in the Ox-LDL induced Smad3 activation and subsequent PAI-1 gene expression in mesangial cells . Positive_regulation EPHB2 APOB 18061125 1846786 stimulation of plasminogen activator inhibitor-1 ( PAI-1 ) expression via transforming growth factor-beta ( TGF-beta ) /Smad signaling in mesangial cells *required* activation of extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 APOB 18061125 1846798 Similar to lovastatin , FTI-277 , which is an inhibitor of Ras farnesylation , decreased the induced *activation* of [ERK/Smad3] and induction of TGF-beta1/PAI-1 . Positive_regulation EPHB2 APOB 18061125 1846801 These results indicate that lovastatin prevents the *induced* [Ras/ERK] activation that results in inhibition of Smad3 activation in mesangial cells with subsequent downregulation of TGF-beta target genes . Positive_regulation EPHB2 APOB 19169357 2027643 These early events included the trafficking of , a structural component of TRL , from apical towards secretory domains , and the rapid , dose dependent *activation* of [ERK] and p38MAPK . Positive_regulation EPHB2 APOB 23371796 2775832 Furthermore , TMP suppressed *induced* activations of [p-ERK] , p-p38 , and p-JNK MAPK . Positive_regulation EPHB2 APOBEC3G 12826666 1134581 also *activated* p38 mitogen activated protein kinase ( p38 MAPK ) and extracellular signal related kinase ( [Erk] ) . Positive_regulation EPHB2 APOE 23246654 2737136 While ApoE did not affect the activation of [ERK] , JNK , and p38 MAPK signaling pathways by RANKL , the phosphorylation of p65 trans-activation domain on serine 536 and transcription activity of NF-?B were *reduced* by overexpression . Positive_regulation EPHB2 APP 9390997 467671 Furthermore , overexpression of a kinase-inactive MEK mutant inhibited phorbol ester stimulation of secretion and *activation* of [ERK] in human embryonic kidney cell lines . Positive_regulation EPHB2 AQP5 10722758 677289 This study demonstrates that is induced by hypertonic stress and that induction *requires* activation of extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 ARAF 12364324 1019133 GLP1 stimulated activation of [Erk] is blocked by inhibitors of MEK , but GLP1 does not *induce* the activation of , B-Raf , C-Raf , or Ras . Positive_regulation EPHB2 AREGB 20726858 2330323 *regulates* the activation of [ERK] and Akt through epidermal growth factor receptor and HER3 signals involved in the progression of pancreatic cancer . Positive_regulation EPHB2 ARF6 15210957 1268096 This study describes a vital role for ARF6 in melanoma cell invasion and documents a link between mediated signaling and [ERK] *activation* . Positive_regulation EPHB2 ARF6 16413265 1494797 To investigate the *role* of in tumor cell invasion and [ERK] activation , a number of methods were employed . Positive_regulation EPHB2 ARF6 17363898 1720400 *dependent* activation of [ERK] and Rac1 modulates epithelial tubule development . Positive_regulation EPHB2 ARF6 17363898 1720404 Second , *induced* [ERK] activation regulates Rac1 activation during tubule initiation through the expression of the receptor for urokinase type plasminogen activator . Positive_regulation EPHB2 ARF6 19247477 2040741 A-RAF induced [ERK] activation is *required* for this step by activating , as A-RAF depletion or inhibition of the A-RAF controlled MEK-ERK cascade blocks recycling . Positive_regulation EPHB2 ARF6 22701712 2615842 is *required* for epidermal growth factor induced [ERK/Rac1] signaling and cell migration in human hepatoma HepG2 cells . Positive_regulation EPHB2 ARG1 12534343 1071111 Specific stimulation of either B1R or B2R by their respective agonists ( 9 ) -BK and Lys-BK *promoted* [ERK] activation and cell growth , whereas selective blockade with specific antagonists des-Arg ( 9 ) - [ Leu(8) ] BK and Hoe 140 respectively obliterated this effect , indicating the presence of both receptor subtypes . Positive_regulation EPHB2 ARG2 12534343 1071112 Specific stimulation of either B1R or B2R by their respective agonists ( 9 ) -BK and Lys-BK *promoted* [ERK] activation and cell growth , whereas selective blockade with specific antagonists des-Arg ( 9 ) - [ Leu(8) ] BK and Hoe 140 respectively obliterated this effect , indicating the presence of both receptor subtypes . Positive_regulation EPHB2 ARHGAP5 17438281 1729250 Reduced expression of the fly chimaerin ortholog in the pupal eye *led* to an excess of interommatidial pigment cells , aberrant cell contacts , and an increase in activated [ERK] that localized specifically to the plasma membrane . Positive_regulation EPHB2 ARHGAP8 20179103 2215772 Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress induced acute [Erk] *activation* and cell migration . Positive_regulation EPHB2 ARHGAP8 20179103 2215774 Interestingly , Pin1 knockdown led to ` super-induction ' of *induced* acute , but not chronic , [Erk] activation upon epidermal growth factor stimulation , in a process independent of GAP modulation . Positive_regulation EPHB2 ARHGAP8 23155002 2723153 SmgGDS antagonizes induced [Ras/ERK] *activation* and neuritogenesis in PC12 cell differentiation . Positive_regulation EPHB2 ARHGEF6 19672789 2162804 However , after 4 h , the time when CagA was delivered into the cells , the activations of PAK1 , [ERK] and NF-kappaB were *inhibited* by down-regulation of using siRNA but not by NT siRNA . Positive_regulation EPHB2 ARHGEF6 19672789 2162812 The interaction of with CagA *activates* PAK1 , [ERK] and NF-kappaB , which induces IL-8 expression in H. pylori infected gastric epithelial cells . Positive_regulation EPHB2 ARRB1 17303558 1718940 This *dependent* [ERK] activity can occur even when the classical tyrosine kinase signaling is impaired . Positive_regulation EPHB2 ARRB2 14711824 1211719 These results are the first to demonstrate reciprocal activity of beta-arrestin isoforms on a signaling pathway and suggest that physiological levels of beta-arrestin1 may act as `` dominant negative '' inhibitors of mediated [ERK] *activation* . Positive_regulation EPHB2 ARRB2 16038799 1437478 *enhances* beta2-adrenergic receptor mediated nuclear translocation of [ERK] . Positive_regulation EPHB2 ARRB2 17384143 1772047 Receptor heterodimerization leads to a switch in signaling : mediated [ERK] *activation* by mu-delta opioid receptor heterodimers . Positive_regulation EPHB2 ARRB2 19014370 2001430 Furthermore , small interfering RNA silencing of *diminished* sustained [ERK] activation induced by U69593 . Positive_regulation EPHB2 ARTN 23603259 2795093 We show that monoclonal antibodies with high affinity to ARTN , completely inhibit *induced* Ret and [ERK] activation in a human neuroblastoma cell line , and block capsaicin induced CGRP secretion from primary rat DRG cultures . Positive_regulation EPHB2 ASAH1 15210766 1262028 Blocking but not sphingosine kinase activity in alveolar macrophages *led* to decreased [ERK] and Akt activity and induction of cell death . Positive_regulation EPHB2 ASIP 18820994 2135367 Since D-Asp is known to be recognized by NMDA receptors , the expression of such receptors in rat HG led us to the hypothesis that acute treatment *induced* the activation of the extracellular signal regulated protein kinase ( [ERK] ) and nitric oxide synthase (NOS) pathways mediated by NMDA . Positive_regulation EPHB2 ASZ1 19489936 2120504 We show that mediated [extracellularly regulated kinase (Erk)] *activation* was responsible for the observed increase in phosphorylation and transactivation activity of p300/CBP . Positive_regulation EPHB2 ATF3 15731359 1402999 We report that : 1 ) insulin induced transcription of , Pip92 , and Insig-1 *required* [MEK-ERK] activation ; Positive_regulation EPHB2 ATP2A2 24508653 2923987 Moreover , high expression of *induced* accumulation of ROS and enhanced [ERK] signaling , thus leading to inactivation of PPAR-? and down-regulation of adipocyte-specific genes . Positive_regulation EPHB2 ATP5O 16973240 1646992 H2O2 and Src dependent transactivation of the EGF receptor *mediates* the stimulatory effect of leptin on renal [ERK] and Na+ , . Positive_regulation EPHB2 ATP5O 18550646 1940617 PTH mediated regulation of *requires* Src kinase dependent [ERK] phosphorylation . Positive_regulation EPHB2 ATP6AP2 18250563 1839651 The ( pro ) *mediated* [ERK] signal transduction is thus a possible new therapeutic target for preventing vascular complications . Positive_regulation EPHB2 ATP6AP2 18974301 1989393 blockade *suppressed* [ERK] activation and the production of MCP-1 and VEGF , but not ICAM-1 , VEGFR-1 , or VEGFR-2 , in AT1-R-deficient mice with CNV and in losartan treated microvascular endothelial cells and macrophages . Positive_regulation EPHB2 ATP6AP2 19879243 2165784 In the present study , we found that ECs express the ( pro ) renin receptor , and that prorenin provoked [ERK] *activation* through ( pro ) independently of the renin-angiotensin system (RAS) . Positive_regulation EPHB2 ATP8A2 11891214 929821 *activated* a MAP kinase and an extracellular signal regulated kinase ( [ERK] ) 1/2 but not p38 or the c-Jun N-terminal kinase (JNK) in both cell types . Positive_regulation EPHB2 AVP 15048868 1225180 Role of protein kinase C in *stimulated* [ERK] and p70S6 kinase phosphorylation . Positive_regulation EPHB2 AVP 15048868 1225186 In addition , inhibition of conventional and novel PKC isoforms by chronic ( 24 h ) exposure to phorbol 12-myristate 13-acetate ( PMA ) inhibited induced *activation* of [ERK] and p70S6 kinase as well as EGF-R phosphorylation . Positive_regulation EPHB2 AVP 15048868 1225187 Our results indicate that PKCdelta plays an important role in *stimulated* [ERK] and p70S6 kinase activation and cell proliferation . Positive_regulation EPHB2 AVP 21816754 2500448 Tolvaptan caused a concentration dependent inhibition of AVP induced cAMP production with an apparent IC ( 50 ) of ~10 ( -10 ) M. Correspondingly , tolvaptan inhibited *induced* [ERK] signaling and cell proliferation . Positive_regulation EPHB2 AVP 22352691 2586862 Staurosporine also markedly attenuated the high glucose induced downregulation of V ( 1A ) receptors on mesangial cells and blocked the depressed [ Ca ( 2+ ) ] ( i ) response and increased [ERK] activity *induced* by . Positive_regulation EPHB2 B3GAT1 11784793 901081 [ERK] MAP kinase activation in superficial spinal cord neurons *induces* prodynorphin and upregulation and contributes to persistent inflammatory pain hypersensitivity . Positive_regulation EPHB2 BACE2 15723799 1376775 Here , we present biochemical and genetic evidence that , the Drosophila homolog of Rap1 , can *activate* D-Raf and [ERK] . Positive_regulation EPHB2 BAI1 23782696 2824145 This constitutive activity of the truncated mutant also *resulted* in enhanced downstream phosphorylation of [ERK] as well as increased receptor association with ß-arrestin2 and increased ubiquitination of the receptor . Positive_regulation EPHB2 BAX 21181094 2385805 Intermittent hypoxia also inhibited expression of pro-anti-apoptotic proteins ( and Bad ) , and induced expression of anti-pro-apoptotic proteins ( Bcl2 and Bcl-xL ) , and *activation* of [ERK] in medulloblastoma cells . Positive_regulation EPHB2 BAX 23732112 2811850 The disruption of mitochondrial outer membrane permeabilisation , the activation of caspase-3/7 and 9 , the downregulation of Bcl-2 , the upregulation of , and the *activation* of p38 MAPK , [ERK] and NF-?B were all observed in HIV-1 Tat treated RPE cells . Positive_regulation EPHB2 BCAR3 24216110 2875931 In this study , we found that *mediates* the induction of [ERK] activation and DNA synthesis by insulin , but not by IGF-1 . Positive_regulation EPHB2 BCL10 15719013 1376495 ( L ) , an antiapoptotic member of the Bcl-2 family that does not affect ER Ca ( 2+ ) uptake , supports neuronal survival but can not *activate* CREB and [Erk] or promote axon regeneration . Positive_regulation EPHB2 BCL10 15878976 1445443 Induction of activity *caused* rapid activation of nuclear factor-kappaB (NF-kappaB) and c-Jun N-terminal kinase (JNK) , but not activation of extracellular signal regulated kinase ( [ERK] ) or p38 mitogen activated protein ( MAP ) kinases . Positive_regulation EPHB2 BCL10 20236757 2272848 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2 , and XIAP ) , as well as *activation* of [Ras/MEK/ERK] and PI3K/Akt signaling . Positive_regulation EPHB2 BCL10 21181094 2385806 Intermittent hypoxia also inhibited expression of pro-anti-apoptotic proteins ( Bax and Bad ) , and induced expression of anti-pro-apoptotic proteins ( Bcl2 and ) , and *activation* of [ERK] in medulloblastoma cells . Positive_regulation EPHB2 BCL10 21742513 2484184 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-8 is associated with increased expression of both multidrug resistance related genes ( MDR1 ) and apoptosis inhibitory proteins ( Bcl-2 , , and XIAP ) , as well as *activation* of PI3K/Akt and [Ras/MEK/ERK] signaling . Positive_regulation EPHB2 BCL2 10097113 601583 Paclitaxel induced apoptosis was associated with phosphorylation of and *activation* of [ERK] and JNK MAPKs . Positive_regulation EPHB2 BCL2 10376521 623371 Taxol induced apoptosis was associated with phosphorylation of both c-Raf-1 and and *activation* of [ERK] and JNK MAP kinases . Positive_regulation EPHB2 BCL2 18674530 1960743 We also found that propofol treatment enhanced expression of anti-apoptotic protein and *activation* of [ERK] concerned with survival . Positive_regulation EPHB2 BCL2 20191008 2216250 In addition , both enhancement of anti-apoptotic protein and *activation* of [Erk] concerned with survival were shown . Positive_regulation EPHB2 BCL2 20236757 2272849 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2 , and XIAP ) , as well as *activation* of [Ras/MEK/ERK] and PI3K/Akt signaling . Positive_regulation EPHB2 BCL2 21181094 2385807 Intermittent hypoxia also inhibited expression of pro-anti-apoptotic proteins ( Bax and Bad ) , and induced expression of anti-pro-apoptotic proteins ( and Bcl-xL ) , and *activation* of [ERK] in medulloblastoma cells . Positive_regulation EPHB2 BCL2 21742513 2484185 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-8 is associated with increased expression of both multidrug resistance related genes ( MDR1 ) and apoptosis inhibitory proteins ( Bcl-2 , , and XIAP ) , as well as *activation* of PI3K/Akt and [Ras/MEK/ERK] signaling . Positive_regulation EPHB2 BCL2 22466960 2583238 Moreover , [ERK] activation upregulated Beclin-1 expression through induction of Bcl-2 phosphorylation , but p53 did not *induce* phosphorylation . Positive_regulation EPHB2 BCL2 23732112 2811851 The disruption of mitochondrial outer membrane permeabilisation , the activation of caspase-3/7 and 9 , the downregulation of , the upregulation of Bax , and the *activation* of p38 MAPK , [ERK] and NF-?B were all observed in HIV-1 Tat treated RPE cells . Positive_regulation EPHB2 BCL2 24523904 2914714 We also demonstrate that the mechanism involves break down of mitochondrial membrane potential , down regulation of and reduced *activation* of Akt and [ERK] 42/44 . Positive_regulation EPHB2 BCL3 20236757 2272850 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2 , and XIAP ) , as well as *activation* of [Ras/MEK/ERK] and PI3K/Akt signaling . Positive_regulation EPHB2 BCL3 21181094 2385808 Intermittent hypoxia also inhibited expression of pro-anti-apoptotic proteins ( Bax and Bad ) , and induced expression of anti-pro-apoptotic proteins ( Bcl2 and ) , and *activation* of [ERK] in medulloblastoma cells . Positive_regulation EPHB2 BCL3 21742513 2484186 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-8 is associated with increased expression of both multidrug resistance related genes ( MDR1 ) and apoptosis inhibitory proteins ( Bcl-2 , , and XIAP ) , as well as *activation* of PI3K/Akt and [Ras/MEK/ERK] signaling . Positive_regulation EPHB2 BCL5 20236757 2272843 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2 , and XIAP ) , as well as *activation* of [Ras/MEK/ERK] and PI3K/Akt signaling . Positive_regulation EPHB2 BCL5 21181094 2385802 Intermittent hypoxia also inhibited expression of pro-anti-apoptotic proteins ( Bax and Bad ) , and induced expression of anti-pro-apoptotic proteins ( Bcl2 and ) , and *activation* of [ERK] in medulloblastoma cells . Positive_regulation EPHB2 BCL5 21742513 2484179 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-8 is associated with increased expression of both multidrug resistance related genes ( MDR1 ) and apoptosis inhibitory proteins ( Bcl-2 , , and XIAP ) , as well as *activation* of PI3K/Akt and [Ras/MEK/ERK] signaling . Positive_regulation EPHB2 BCL6 20236757 2272844 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2 , and XIAP ) , as well as *activation* of [Ras/MEK/ERK] and PI3K/Akt signaling . Positive_regulation EPHB2 BCL6 21181094 2385803 Intermittent hypoxia also inhibited expression of pro-anti-apoptotic proteins ( Bax and Bad ) , and induced expression of anti-pro-apoptotic proteins ( Bcl2 and ) , and *activation* of [ERK] in medulloblastoma cells . Positive_regulation EPHB2 BCL6 21742513 2484180 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-8 is associated with increased expression of both multidrug resistance related genes ( MDR1 ) and apoptosis inhibitory proteins ( Bcl-2 , , and XIAP ) , as well as *activation* of PI3K/Akt and [Ras/MEK/ERK] signaling . Positive_regulation EPHB2 BCL9 20236757 2272845 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2 , and XIAP ) , as well as *activation* of [Ras/MEK/ERK] and PI3K/Akt signaling . Positive_regulation EPHB2 BCL9 21181094 2385804 Intermittent hypoxia also inhibited expression of pro-anti-apoptotic proteins ( Bax and Bad ) , and induced expression of anti-pro-apoptotic proteins ( Bcl2 and ) , and *activation* of [ERK] in medulloblastoma cells . Positive_regulation EPHB2 BCL9 21742513 2484181 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-8 is associated with increased expression of both multidrug resistance related genes ( MDR1 ) and apoptosis inhibitory proteins ( Bcl-2 , , and XIAP ) , as well as *activation* of PI3K/Akt and [Ras/MEK/ERK] signaling . Positive_regulation EPHB2 BCR 10438726 635003 Because extracellular signal regulated kinases ( ERKs ) couple upstream signaling pathways to gene activation and are activated by B-cell antigen receptor (BCR) signaling , we examined whether CD22 ligation also activated ERKs and/or modified *induced* [ERK] activation . Positive_regulation EPHB2 BCR 11466342 839901 Although both CD72 and *induced* Btk dependent [ERK] activation , CD72 mediated proliferation is more resistant to blocking of ERK activity than that of BCR , as shown by the proliferation response of B cells treated with PD98059 and dibutyryl cAMP , agents that inhibit ERK activity . Positive_regulation EPHB2 BCR 11726515 884442 In vivo expression of a Grb2 mutant where Tyr209 was changed to phenylalanine enhanced *induced* [ERK] activation and fibroblast transformation , and potentiated and prolonged Grb2 mediated activation of Ras , mitogen activated protein kinase and c-Jun N-terminal kinase in response to EGF stimulation . Positive_regulation EPHB2 BCR 11823472 922652 We report that inhibition of mitogen activated protein kinase/extracellular signal regulated kinase kinase ( MEK)-1/2 blocked *induced* activation of extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 BCR 11976336 954032 Here we demonstrate through the use of PI 3-kinase inhibitors and a dominant negative PI 3-kinase construct that the *induced* phosphorylation and activation of [ERK] is dependent on PI 3-kinase . Positive_regulation EPHB2 BCR 12095152 960710 In contrast , cross linking *resulted* in [ERK] activation , although the activation in quiescent cells was case dependent . Positive_regulation EPHB2 BCR 12095152 960713 These results suggest that some signaling pathways , such as the *activation* of [ERK] through , are functional in B-CLL cells despite the extensive impairment of signaling pathways . Positive_regulation EPHB2 BCR 12411479 1010822 Loss of Raf-1 has no effect on mediated [ERK] *activation* , whereas B-Raf-deficient DT40 cells display a reduced basal ERK activity as well as a shortened BCR mediated ERK activation . Positive_regulation EPHB2 BCR 12411479 1010827 Our study shows that mediated [ERK] *activation* involves a cooperation of both B-Raf and Raf-1 , which are activated specifically in a temporally distinct manner . Positive_regulation EPHB2 BCR 12444544 1017449 These data implicate the Src kinase family in Stat5 and [Erk] *activation* downstream of , and identify myeloid-specific Src kinases as potential drug targets in CML . Positive_regulation EPHB2 BCR 12514734 1039169 Decreased LAB expression led to a reduction in *mediated* calcium flux and [Erk] activation . Positive_regulation EPHB2 BCR 12904304 1150326 Preventing Rap activation had no effect on *induced* activation of [ERK] . Positive_regulation EPHB2 BCR 15569688 1368314 With respect to MAPK activation , HSH2 was not observed to alter the activation of [ERK] or p38 in *response* to ligation , but it does significantly potentiate JNK activation . Positive_regulation EPHB2 BCR 15749869 1379669 B cell receptor (BCR) cross-talk : CD40 engagement enhances *induced* [ERK] activation . Positive_regulation EPHB2 BCR 15843535 1398456 B cell receptor (BCR) cross-talk : IL-4 creates an alternate pathway for *induced* [ERK] activation that is phosphatidylinositol 3-kinase independent . Positive_regulation EPHB2 BCR 15843535 1398461 As in the classical pathway , *induced* [ERK] activation in the new , PI3K independent pathway required MEK and was reflected in c-Raf . Positive_regulation EPHB2 BCR 16135797 1450457 Similarly , *mediated* total tyrosine phosphorylation and phosphorylation of [Erk] , p38 , and JNK , as well as immunoreceptor mediated Ca ( 2+ ) responses , are normal in SKAP-HOM ( -/- ) animals . Positive_regulation EPHB2 BCR 16585562 1544192 Intracellular calcium signaling and [ERK] activation in *response* to engagement were also proportionately decreased and delayed , respectively , with stepwise reduction of plcgamma2 dosage in a BLNK ( null ) background . Positive_regulation EPHB2 BCR 16809760 1580477 B-cell proliferation , cell cycle progression , PLC-gamma2 phosphorylation , calcium mobilization , NF-ATp dephosphorylation , and [Erk] and Jnk activation in *response* to ligation were all impaired . Positive_regulation EPHB2 BCR 17384277 1665253 RNA silencing experiments showed that knocking down Gab1 adaptor protein in BL41 human Burkitt lymphoma cells significantly reduced *induced* [Erk] phosphorylation , indicating that Gab1 plays a pivotal role in regulating Erk activity in B cells . Positive_regulation EPHB2 BCR 17522256 1751327 Coligation of this fusion protein with the B cell receptor (BCR) inhibited *mediated* calcium mobilization , intracellular tyrosine phosphorylation , and [Erk] kinase activation . Positive_regulation EPHB2 BCR 17640867 1787652 The overexpression of LPXN in mouse A20 B lymphoma cells led to the suppression of *induced* activation of JNK , p38 MAPK , and , to a lesser extent , Akt , but not [ERK] and NFkappaB , suggesting that LPXN can selectively repress BCR signaling . Positive_regulation EPHB2 BCR 17656488 1793746 Using Western blotting and phospho-specific flow cytometry , we now show that the kinetics and magnitude of mediated *activation* of [ERK-MAPK] are markedly attenuated in WEHI-231 cells and splenic B cells that have been exposed to low and nontoxic burdens of Hg ( +2 ) . Positive_regulation EPHB2 BCR 17724683 1801601 *mediated* phosphorylation of Akt and [Erk] is sensitive to the PI3K catalytic inhibitor wortmannin in both marginal zone ( MZ ) and follicular ( FO ) cells . Positive_regulation EPHB2 BCR 18448454 1921238 It was previously shown that Bam32-deficient mice have defects in various aspects of B cell activation including induced [Erk] *activation* , BCR induced proliferation and T-independent antibody responses . Positive_regulation EPHB2 BCR 18481208 1840546 In contrast , *induced* activation of [ERK] , JNK , p38 , and Akt was not affected by ROS depletion . Positive_regulation EPHB2 BCR 18725396 1984985 We found that in CB B cells *activation* of extracellular signal regulated kinase ( [ERK] ) and p38 following ligation of CD40 but not of the was inefficient . Positive_regulation EPHB2 BCR 19218240 2054347 We have identified a 10-amino acid Ras binding domain within BLNK that is necessary for restoration of mediated [ERK] *activation* in BLNK-deficient B cells and for anti-apoptotic signaling . Positive_regulation EPHB2 BCR 21715303 2471233 Using this vector in a murine syngeneic BM transplantation model for BCR-ABL induced chronic myeloid leukemia , we find that oncogene expression and target knockdown in primary hematopoietic cells with this vector is efficient both in vitro and in vivo , and demonstrate that Raf1 , but not BRAF , modulates *dependent* [ERK] activation and transformation of hematopoietic cells . Positive_regulation EPHB2 BCR 23325840 2758313 This results in the reduction of HS1 activation along with that of cytoskeletal effector VAV1 and the downstream kinase [ERK] also in the *presence* of and CXC chemokine receptor CXCR4 stimulation . Positive_regulation EPHB2 BCR 23942237 2840873 Taken together , these data suggest that LUBAC mediated linear polyubiquitination is essential for B-cell development and activation , possibly via canonical NF-?B and [ERK] activation *induced* by the TNF receptor superfamily , but not by the . Positive_regulation EPHB2 BCR 24989471 2948146 Here , we indicate that the ZIP9 induces increase in intracellular zinc level and plays an important role in the phosphorylation of Akt and [Erk] in *response* to activation . Positive_regulation EPHB2 BCR 8871635 389568 CD40 did not activate either of these kinases , nor did it affect *induced* [ERK] activation . Positive_regulation EPHB2 BCR 9763608 537167 Here we demonstrate that the *induced* [ERK] activation is reduced by loss of Grb2 or expression of a dominant negative form of Ras , RasN17 , whereas this response is not affected by loss of Shc . Positive_regulation EPHB2 BDKRB1 12534343 1071109 Specific stimulation of either or B2R by their respective agonists des-Arg ( 9 ) -BK and Lys-BK *promoted* [ERK] activation and cell growth , whereas selective blockade with specific antagonists des-Arg ( 9 ) - [ Leu(8) ] BK and Hoe 140 respectively obliterated this effect , indicating the presence of both receptor subtypes . Positive_regulation EPHB2 BDKRB1 20228252 2281588 The prolonged phase of *dependent* [ERK] activation was also inhibited by beta-arrestin 2 knockdown . Positive_regulation EPHB2 BDKRB2 12534343 1071110 Specific stimulation of either B1R or by their respective agonists des-Arg ( 9 ) -BK and Lys-BK *promoted* [ERK] activation and cell growth , whereas selective blockade with specific antagonists des-Arg ( 9 ) - [ Leu(8) ] BK and Hoe 140 respectively obliterated this effect , indicating the presence of both receptor subtypes . Positive_regulation EPHB2 BDKRB2 12534343 1071113 However , blockade of B1R also inhibited mediated [ERK] *activation* and cell growth , and , similarly , antagonism of B2R inhibited the B1R mediated response . Positive_regulation EPHB2 BDNF 10507550 649739 EtOH decreased ERK activation in vivo and decreased nuclear translocation of *stimulated* [ERK] in situ . Positive_regulation EPHB2 BDNF 10683153 669551 On the other hand , *stimulated* the kinase activity of CDK5 and induced appearance of an active form of [ERK] transiently . Positive_regulation EPHB2 BDNF 11689163 876106 *led* to a rapid ( 30 min ) and sustained ( 6 h ) phosphorylation of [ERK] . Positive_regulation EPHB2 BDNF 11739615 886671 We also found that inhibition of PI3K reduces *induced* [Erk] phosphorylation , indicating that cross-talk between these pathways may play a prominent role in MSNs . Positive_regulation EPHB2 BDNF 12504600 1026939 We observed , both in vitro and in vivo , that exogenous *induced* a rapid activation of [ERK] , a signaling kinase important in the development of acute pain . Positive_regulation EPHB2 BDNF 14572451 1155787 signaling via TrkB receptors but not SP signaling via NK(1) were also *involved* in [ERK] recruitment . Positive_regulation EPHB2 BDNF 14684879 1179335 We also show that *activation* of extracellular signal regulated kinase ( [Erk] ) by is required to overcome inhibition by MAG , and that activated Erk transiently inhibits phosphodiesterase 4 ( PDE4 ) , the enzyme that hydrolyzes cAMP . Positive_regulation EPHB2 BDNF 15207334 1261476 Therefore , we suggest that after inflammation near the cell body , NGF synthesized within the nerve root and DRG *induces* expression through trkA receptors and intracellular [ERK-MAPK] . Positive_regulation EPHB2 BDNF 15579142 1344805 Taken together , our results demonstrate that the *activation* of [ERK] and p38 and also the changes in NPY and expression may occur in different populations of DRG neurons after CCI , partially through alterations in the target derived NGF . Positive_regulation EPHB2 BDNF 15977164 1428304 TrkB expression and [phospho-ERK] *activation* by in rat spinothalamic tract neurons . Positive_regulation EPHB2 BDNF 15977164 1428306 Because the spinothalamic tract ( STT ) is a well characterized pathway for its role in the transfer and integration of sensory and nociceptive informations , this study in rats aimed to 1 ) determine whether neurons of the STT pathway express the TrkB receptor , 2 ) establish the rostrocaudal and laminar distribution of STT-TrkB neurons in the whole spinal cord , and 3 ) test the potential functionality of TrkB expression in these cells by investigating the ability of to *activate* the MAP kinase [ERK] . Positive_regulation EPHB2 BDNF 16938627 1609139 *stimulated* [ERK] phosphorylation ( pERK ) within 10min and supported stimulation from 20 to 60min. Ethanol decreased basal pERK and reduced the magnitude of BDNF stimulation of ERK under both conditions . Positive_regulation EPHB2 BDNF 17013927 1634102 In LAR-/- neurons , induced *activation* of TrkB , Shc , AKT , [ERK] , and CREB was significantly decreased ; Positive_regulation EPHB2 BDNF 17532077 1778379 *activated* [ERK] in the dorsal horn , and anti-BDNF blocked the DRG induced ERK activation . Positive_regulation EPHB2 BDNF 17532077 1778383 These results suggest *roles* of in the DRG induced [ERK] activation in the embryonic dorsal horn . Positive_regulation EPHB2 BDNF 18055129 1852600 Lastly , in contrast to a complete block of synaptic NMDA receptor activation of ERK by extrasynaptic NMDA receptors , activation of extrasynaptic NMDA receptors had no effect upon [ERK] *activation* by . Positive_regulation EPHB2 BDNF 18353779 1905980 In this study , we report that blocking clathrin , dynamin , or AP2 in cultured neurons of the central nervous system inhibited induced *activation* of Akt but not [ERK] . Positive_regulation EPHB2 BDNF 18373519 1944109 The regional and time-specific changes in the levels of BDNF mRNA , protein and [phospho-ERK] with colitis may be a *result* of increased transcription of in DRG and anterograde transport of BDNF from DRG to spinal cord where it activates intracellular signalling molecules such as ERK1/2 . Positive_regulation EPHB2 BDNF 18718506 1984865 These data suggest that increased levels are not sufficient to explain the beneficial effects of mild hypothermia after cardiac arrest , and that exogenous BDNF administration does not *increase* extracellular [ERK] signaling . Positive_regulation EPHB2 BDNF 19222702 2071881 *increased* both Akt and [Erk] phosphorylation , but pharmacological blockade of these kinase pathways ( with wortmannin and U0126 , respectively ) did not reduce the Smad phosphorylation produced by the BMP7 + BDNF combination . Positive_regulation EPHB2 BDNF 20156366 2214774 In addition , the increased Pyk2 and [ERK] activities *induced* by were significantly inhibited by blocking TrkB expression , so was the invasion of A549 cells . Positive_regulation EPHB2 BDNF 21379385 2400318 Consistently , upon *stimulation* with the TRKB ligand , these mutants were impaired in activating TRKB and its downstream effectors AKT and [ERK] . Positive_regulation EPHB2 BDNF 21486081 2428415 Hesperetin also stimulated the activation of Akt , [ERK] , and CREB as well as *induced* , PPAR? coactivator 1a ( PGC-1a ) , and seladin-1 ( selective Alzheimer 's disease indicator-1 ) via both ER and TrkA in the cells . Positive_regulation EPHB2 BDNF 21653848 2442137 Phosphorylation of ephrin-B1 , but not [EphB2] , was *induced* by both conditioning and application and was inhibited by postsynaptic injections of ephrin-B antibody . Positive_regulation EPHB2 BDNF 21775604 2456864 Moreover , we find that TrkB axonal transport mediated by JIP3 could regulate *induced* [Erk] activation and axonal filopodia formation . Positive_regulation EPHB2 BDNF 22022520 2499057 *increased* [ERK] phosphorylation ( P-ERK ) and nuclear ERK entry . Positive_regulation EPHB2 BDNF 22022520 2499059 Ephrin-A5 suppressed *induced* [ERK] activity and might sequester P-ERK in the cytoplasm . Positive_regulation EPHB2 BDNF 23069755 2763562 In CNS neurons , *triggers* activation of phospholipase C? ( PLC? ) , mitogen activated protein/extracellular signal regulated kinase ( [MAPK/ERK] ) , and phosphoinositide 3-kinase (PI3K)/Akt pathways , influencing neuronal cells beneficially through these intracellular signaling cascades . Positive_regulation EPHB2 BLNK 21074890 2407166 CD40 stimulation alone also activates B cell linker (BLNK) , Bruton tyrosine kinase (Btk) , and Vav-2 downstream of Syk , and significantly enhances BCR induced formation of complex consisting of , Vav-2 , Btk , , and phospholipase C-gamma2 ( PLC-?2 ) *leading* to activation of extracellular signal regulated kinase ( [ERK] ) , p38 mitogen activated protein kinase , Akt , and NF-?B required for optimal B cell activation . Positive_regulation EPHB2 BMF 20861305 2342977 Consistent with these data , hypoxic conditions inhibit luminal clearing during morphogenesis in human mammary epithelial acini when grown in three-dimensional cultures and are associated with decreased expression of Bim and as well as [Erk] *activation* . Positive_regulation EPHB2 BMP1 20851880 2342773 Because signaling *induces* [Erk] activation in osteoblasts , we sought to investigate whether BMP induced Erk signaling regulates Runx2 acetylation and stability . Positive_regulation EPHB2 BMP1 21948155 2492542 These results suggest that , besides the Smad signaling pathways , induced *activation* of PI3K and [Erk] contribute to EMT morphologic conversion of the PC-3 prostate cancer cells . Positive_regulation EPHB2 BMP1 22056560 2513924 We therefore focused on the relationship between Osterix and Erk1/2 during osteoblast differentiation because signaling *induces* [Erk] activation in osteoblasts . Positive_regulation EPHB2 BMP1 22687552 2643707 *induced* the phosphorylation of [ERK] , JNK , and p38 , and the nuclear translocation of NF-?B p50/p65 , which are the main signaling molecules downstream from TLR4 . Positive_regulation EPHB2 BMP10 20851880 2342781 Because signaling *induces* [Erk] activation in osteoblasts , we sought to investigate whether BMP induced Erk signaling regulates Runx2 acetylation and stability . Positive_regulation EPHB2 BMP10 21948155 2492550 These results suggest that , besides the Smad signaling pathways , *induced* activation of PI3K and [Erk] contribute to EMT morphologic conversion of the PC-3 prostate cancer cells . Positive_regulation EPHB2 BMP10 22056560 2513932 We therefore focused on the relationship between Osterix and Erk1/2 during osteoblast differentiation because signaling *induces* [Erk] activation in osteoblasts . Positive_regulation EPHB2 BMP15 20851880 2342774 Because BMP signaling induces Erk activation in osteoblasts , we sought to investigate whether *induced* [Erk] signaling regulates Runx2 acetylation and stability . Positive_regulation EPHB2 BMP15 21948155 2492543 These results suggest that , besides the Smad signaling pathways , induced *activation* of PI3K and [Erk] contribute to EMT morphologic conversion of the PC-3 prostate cancer cells . Positive_regulation EPHB2 BMP15 22056560 2513925 We therefore focused on the relationship between Osterix and Erk1/2 during osteoblast differentiation because signaling *induces* [Erk] activation in osteoblasts . Positive_regulation EPHB2 BMP2 11344048 814126 This report shows that *activates* [ERK] and p38 , but not JNK , in C2C12 cells . Positive_regulation EPHB2 BMP2 19217886 2044392 On the other hand , *induced* [Erk] phosphorylation ( p44/p42 ) and cell proliferation were suppressed in the presence of cAMP . Positive_regulation EPHB2 BMP2 20851880 2342775 Because signaling *induces* [Erk] activation in osteoblasts , we sought to investigate whether BMP induced Erk signaling regulates Runx2 acetylation and stability . Positive_regulation EPHB2 BMP2 21570392 2445209 We found that stimulation of in gastric cancer cells *enhanced* the phosphorylation of AKT and [ERK] . Positive_regulation EPHB2 BMP2 21948155 2492544 These results suggest that , besides the Smad signaling pathways , *induced* activation of PI3K and [Erk] contribute to EMT morphologic conversion of the PC-3 prostate cancer cells . Positive_regulation EPHB2 BMP2 22056560 2513926 We therefore focused on the relationship between Osterix and Erk1/2 during osteoblast differentiation because signaling *induces* [Erk] activation in osteoblasts . Positive_regulation EPHB2 BMP2 24269886 2893094 HtrA1 is upregulated during RANKL induced osteoclastogenesis , and negatively regulates osteoblast differentiation and *induced* Smad1/5/8 , [ERK] and p38 phosphorylation . Positive_regulation EPHB2 BMP3 20851880 2342776 Because BMP signaling induces Erk activation in osteoblasts , we sought to investigate whether *induced* [Erk] signaling regulates Runx2 acetylation and stability . Positive_regulation EPHB2 BMP3 21948155 2492545 These results suggest that , besides the Smad signaling pathways , induced *activation* of PI3K and [Erk] contribute to EMT morphologic conversion of the PC-3 prostate cancer cells . Positive_regulation EPHB2 BMP3 22056560 2513927 We therefore focused on the relationship between Osterix and Erk1/2 during osteoblast differentiation because signaling *induces* [Erk] activation in osteoblasts . Positive_regulation EPHB2 BMP4 19819988 2154615 Pretreatment of MG63 cells with Arg-Gly-Asp-Ser , which blocks the cell-extracellular matrix interaction , or transfection with beta ( 3 ) integrin-specific siRNA inhibited *induced* [ERK] and Smad1/5 phosphorylations . Positive_regulation EPHB2 BMP4 19819988 2154618 BMP-4 induced transient increases in associations of beta ( 3 ) -integrin with focal adhesion kinase and Shc , the dominant negative mutants of which inhibited *induced* [ERK] and Smad1/5 phosphorylations . Positive_regulation EPHB2 BMP4 20851880 2342777 Because signaling *induces* [Erk] activation in osteoblasts , we sought to investigate whether BMP induced Erk signaling regulates Runx2 acetylation and stability . Positive_regulation EPHB2 BMP4 21948155 2492546 These results suggest that , besides the Smad signaling pathways , *induced* activation of PI3K and [Erk] contribute to EMT morphologic conversion of the PC-3 prostate cancer cells . Positive_regulation EPHB2 BMP4 22056560 2513928 We therefore focused on the relationship between Osterix and Erk1/2 during osteoblast differentiation because signaling *induces* [Erk] activation in osteoblasts . Positive_regulation EPHB2 BMP5 20851880 2342778 Because BMP signaling induces Erk activation in osteoblasts , we sought to investigate whether *induced* [Erk] signaling regulates Runx2 acetylation and stability . Positive_regulation EPHB2 BMP5 21948155 2492547 These results suggest that , besides the Smad signaling pathways , induced *activation* of PI3K and [Erk] contribute to EMT morphologic conversion of the PC-3 prostate cancer cells . Positive_regulation EPHB2 BMP5 22056560 2513929 We therefore focused on the relationship between Osterix and Erk1/2 during osteoblast differentiation because signaling *induces* [Erk] activation in osteoblasts . Positive_regulation EPHB2 BMP6 20851880 2342779 Because signaling *induces* [Erk] activation in osteoblasts , we sought to investigate whether BMP induced Erk signaling regulates Runx2 acetylation and stability . Positive_regulation EPHB2 BMP6 21948155 2492548 These results suggest that , besides the Smad signaling pathways , *induced* activation of PI3K and [Erk] contribute to EMT morphologic conversion of the PC-3 prostate cancer cells . Positive_regulation EPHB2 BMP6 22056560 2513930 We therefore focused on the relationship between Osterix and Erk1/2 during osteoblast differentiation because signaling *induces* [Erk] activation in osteoblasts . Positive_regulation EPHB2 BMP7 20851880 2342780 Because BMP signaling induces Erk activation in osteoblasts , we sought to investigate whether *induced* [Erk] signaling regulates Runx2 acetylation and stability . Positive_regulation EPHB2 BMP7 21948155 2492549 These results suggest that , besides the Smad signaling pathways , induced *activation* of PI3K and [Erk] contribute to EMT morphologic conversion of the PC-3 prostate cancer cells . Positive_regulation EPHB2 BMP7 22056560 2513931 We therefore focused on the relationship between Osterix and Erk1/2 during osteoblast differentiation because signaling *induces* [Erk] activation in osteoblasts . Positive_regulation EPHB2 BPI 17012258 1629178 , but not control protein thaumatin , *activated* [extracellular regulated kinase (ERK)] and AKT , and increased DNA synthesis in RPE and RPC but not in REC . Positive_regulation EPHB2 BPI 18055828 1833399 Heparitinase , phosphatidylinositol-specific phospholipase C , and anti-GPC4 antibody suppressed *induced* [ERK] and Akt phosphorylation in bovine RPE . Positive_regulation EPHB2 BPI 23740083 2807053 In addition , can inhibit angiogenesis , suppress LPS mediated platelet activation , increase DNA synthesis , and *activate* [ERK/Akt] signaling . Positive_regulation EPHB2 BPNT1 15731359 1402997 We report that : 1 ) insulin induced transcription of ATF-3 , , and Insig-1 *required* [MEK-ERK] activation ; Positive_regulation EPHB2 BRAF 11027277 738755 PI3-K and endocytosis may also regulate ERK signaling at a second site downstream of Ras , since both rapid [ERK] activation and the Ras dependent *activation* of the MAP kinase kinase kinase are blocked by inhibition of either PI3-K or endocytosis . Positive_regulation EPHB2 BRAF 11296228 801472 [MEK/ERK] activation is normal in Raf-1-deficient cells and embryos , and is probably *mediated* by . Positive_regulation EPHB2 BRAF 12364324 1019128 GLP1 stimulated activation of [Erk] is blocked by inhibitors of MEK , but GLP1 does not *induce* the activation of A-Raf , , C-Raf , or Ras . Positive_regulation EPHB2 BRAF 15278365 1277268 Transfection of 95 kDa into confluent NHK *resulted* in a cAMP dependent increase in [ERK] phosphorylation and cell proliferation . Positive_regulation EPHB2 BRAF 15761501 1397179 Here we show that the 3 proteins function along a linear oncogenic signaling cascade in which RET/PTC induces RAS dependent BRAF activation and RAS- and *dependent* [ERK] activation . Positive_regulation EPHB2 BRAF 15791648 1397427 The inhibition of phosphatidylinositol 3-kinase (PI3K)/Akt signaling by LY294002 increased the [Erk] activation *induced* by the mutant B-raf proteins , as well as by wild-type . Positive_regulation EPHB2 BRAF 15995848 1441279 In these islets , the Rap-B-Raf signalling pathway was activated preferentially compared with Ras and Raf-1 , and activated Rap and *mediated* [ERK] stimulation in kinase assays in vitro . Positive_regulation EPHB2 BRAF 16432225 1521554 Essential *role* of in [ERK] activation during extraembryonic development . Positive_regulation EPHB2 BRAF 18374154 1888366 constitutively *activates* [ERK] signaling and promotes proliferation , survival , and tumor growth . Positive_regulation EPHB2 BRAF 18473997 1840418 Supporting its classification as an oncogene , V600E *stimulates* [ERK] signaling , induces proliferation and is capable in model systems of promoting transformation . Positive_regulation EPHB2 BRAF 18490924 1944916 is *required* for [ERK] activation and tumor progression in a mouse model of pancreatic beta-cell carcinogenesis . Positive_regulation EPHB2 BRAF 18490924 1944918 We find that is dispensable for the proliferation of tumor cells in culture , but *necessary* for [ERK] activation and for the expression of angiogenic factors by tumor cells in vivo and in vitro . Positive_regulation EPHB2 BRAF 18563700 1940821 Artificial [Erk] *activation* by expression of constitutively active Mek1 and failed to block ephrin-A5 effects on growth cones , and inhibitors of the Erk pathway also failed to inhibit collapse by ephrin-A5 . Positive_regulation EPHB2 BRAF 19638574 2118599 Depletion of , but not that of C-RAF , *inhibited* [ERK] phosphorylation as well as suppressed cell growth and induced G ( 1 ) arrest in cells with wild-type KRAS . Positive_regulation EPHB2 BRAF 21923753 2539128 We show that UVR induced [ERK] signalling , *mediated* by , regulates p16 ( CDKN2A ) expression at the transcriptional , and possibly translational level . Positive_regulation EPHB2 BRAF 22506009 2583954 However , ( T599A ) did not destabilize the inactive conformation of the B-RAF kinase , and did not *induce* increased [ERK] phosphorylation or C-RAF transactivation . Positive_regulation EPHB2 BRAF 22892241 2666326 However , unlike ( V600E ) Braf , Mek/Erk pathway activation was mediated by both Craf and , and ATP-competitive RAF inhibitors *induced* paradoxical [Mek/Erk] pathway activation . Positive_regulation EPHB2 BRAF 23359496 2743167 Kidins220/ARMS associates with and the TCR , *promoting* sustained [Erk] signaling in T cells . Positive_regulation EPHB2 BRAF 23893412 2839590 Recently , it has been reported that in melanoma cells harboring oncogenic Ras mutations , does not bind to Ras and does not *contribute* to basal [ERK] activation . Positive_regulation EPHB2 BRAF 23907581 2822557 Substitution of BRAF lysine 578 with arginine ( K578R ) inhibited mediated [ERK] *activation* . Positive_regulation EPHB2 BRAF 25219500 2958291 ( V600E ) *increases* [BRAF/MEK/ERK] signaling resulting in phosphorylation and elevated levels of MAFG , which drives DNA binding . Positive_regulation EPHB2 BRCC3 17143545 1668119 These findings demonstrate that BRCC3 is a novel effector of Raf-1 , and implicate a *role* of in modulation of [p-ERK] , cell survival and proliferation . Positive_regulation EPHB2 BSG 19561311 2110648 and 5 ) resveratrol attenuates IL-18- and mediated PI3K , Akt , and [ERK] *activations* ; Positive_regulation EPHB2 BSG 20107538 2178633 Stimulation of with its specific monoclonal antibody induced the expression of matrix metalloproteinase (MMP)-9 in THP-1 cells and it was *suppressed* by inhibitors of both [ERK] and NF-kappaB . Positive_regulation EPHB2 BSG 20847954 2319253 Activation of with cyclophilin a *induces* the expression of IFITM1 through [ERK] and PI3K in THP-1 cells . Positive_regulation EPHB2 BSG 24014600 2851461 Suppression of by siRNA significantly ( P < 0.05 ) *reduced* trophoblast-endometrial cell interaction , cell invasion , syncytialization , differentiation and [ERK] activation of BeWo cells . Positive_regulation EPHB2 BTC 15192046 1280961 The increased [Erk] *activation* by associated with antiapoptotic function . Positive_regulation EPHB2 BTC 24534906 2918974 Infecting the cells with Ad-PKG II and stimulating the kinase with 8-pCPT-cGMP efficiently inhibited the phosphorylation of the EGFR and [MAPK/ERK] *induced* by EGF , TGF-a , and EPR . Positive_regulation EPHB2 BTK 11466342 839902 Although both CD72 and BCR induced dependent [ERK] *activation* , CD72 mediated proliferation is more resistant to blocking of ERK activity than that of BCR , as shown by the proliferation response of B cells treated with PD98059 and dibutyryl cAMP , agents that inhibit ERK activity . Positive_regulation EPHB2 BTK 12054657 951330 In addition , we have investigated the involvement of PI 3-K in the MAPKs and [ERK] and JNK phosphorylation , in the *presence* or absence of . Positive_regulation EPHB2 BTK 21074890 2407165 CD40 stimulation alone also activates B cell linker (BLNK) , Bruton tyrosine kinase (Btk) , and Vav-2 downstream of Syk , and significantly enhances BCR induced formation of complex consisting of , Vav-2 , , BLNK , and phospholipase C-gamma2 ( PLC-?2 ) *leading* to activation of extracellular signal regulated kinase ( [ERK] ) , p38 mitogen activated protein kinase , Akt , and NF-?B required for optimal B cell activation . Positive_regulation EPHB2 BTRC 11412047 828332 *induced* a rapid and transient activation of [ERK] and p38 in a dose dependent manner . Positive_regulation EPHB2 BTRC 15465815 1342228 These data suggest that Spred-1 negatively regulates hematopoiesis by suppressing not only induced but also IL-3 induced [ERK] *activation* . Positive_regulation EPHB2 BTRC 19956885 2185003 LY294002 and PD98059 inhibited *induced* Akt and [Erk] activation in H209 cells , respectively . Positive_regulation EPHB2 BTRC 21330471 2415114 Half the population phosphorylated [Erk] in *response* to between 0.9 and 1.2 minutes , and S6 phosphorylation followed approximately a minute later ( t & frac12 ; ( pS6 rise ) = 2.2-2.7 minutes ) . Positive_regulation EPHB2 C1QA 16908670 1601626 We show that ERK signaling is required for phagocytosis of apoptotic cells and that [ERK] phosphorylation in *response* to apoptotic cells or is defective in ABCA7-deficient cells . Positive_regulation EPHB2 C1QB 16908670 1601627 We show that ERK signaling is required for phagocytosis of apoptotic cells and that [ERK] phosphorylation in *response* to apoptotic cells or is defective in ABCA7-deficient cells . Positive_regulation EPHB2 C3 15153516 1250123 In contrast , *induced* a transient Ca ( 2+ ) mobilization and [ERK] phosphorylation but failed to stimulate TrkA phosphorylation , NFAT activation , or MIP-1beta production . Positive_regulation EPHB2 C3 15153516 1250126 Surprisingly , significantly *enhanced* NGF induced NFAT activation , [ERK] phosphorylation , and MIP-1beta production . Positive_regulation EPHB2 C5 10698349 579165 Analysis of mitogen activated protein kinases (MAPK) pathways induced by C5b-9 in aortic SMC revealed that extracellular signal regulated kinase ( [ERK] ) 1 , c-jun NH2-terminal kinase (JNK) 1 , and p38 MAPK are all *activated* by . Positive_regulation EPHB2 C5 12057768 952189 Together these data suggest that mediated AP-1 activation *requires* both the activation of the [ERK] and JNK pathways , whereas activation of the JNK pathway is sufficient to increase AP-1 binding with ADP . Positive_regulation EPHB2 C5 15855657 1439575 *induced* [ERK] threonine202/tyrosine204 phosphorylation ( which correlates with activation ) in GEC in culture and PHN in vivo . Positive_regulation EPHB2 C5 16116186 1449012 or IB-MECA activated the PI3K/Akt signaling pathway and *induced* the phosphorylation of the MAPK p38 , [ERK] , and JNK . Positive_regulation EPHB2 C5 24043889 2851690 [Gai/c-Raf/MEK/ERK] signaling *induced* by was amplified in macrophages but not in monocytes by LPS . Positive_regulation EPHB2 C7orf41 24681962 2931395 In K562 cells , ectopic expression of significantly increased CD61 expression , *enhanced* [ERK] and JNK signaling , and upregulated RUNX1 and FLI1 , whereas C7ORF41 knockdown caused an opposite phenotype . Positive_regulation EPHB2 CA2 10537288 563191 These results provide evidence that GnRHa stimulation of [ERK] activity may be *mediated* by Gbetagamma protein , not by PMA-sensitive protein kinase C nor extracellular in the Caov-3 human ovarian cancer cell line , suggesting that this cascade may play an important role in the antiproliferative effect of GnRHa . Positive_regulation EPHB2 CA2 11914123 984253 *mediated* activation of [ERK] in hepatocytes by norepinephrine and prostaglandin F2 alpha : role of calmodulin and Src kinases . Positive_regulation EPHB2 CA2 11914123 984256 The present data indicate that is *involved* in [ERK] activation induced by hormones acting on G protein coupled receptors in hepatocytes , and suggest that calmodulin and Src kinases might play a role in these signaling pathways . Positive_regulation EPHB2 CA2 14519666 1147828 IL-1 induced release of from internal stores is dependent on cell-matrix interactions and *regulates* [ERK] activation . Positive_regulation EPHB2 CA2 15336602 1291254 Using Western analysis , we observed that an increase in extracellular *resulted* in delayed activation of extracellular signal regulated kinase ( [ERK] ) in PC-3 cells . Positive_regulation EPHB2 CA2 15574735 1344631 Interestingly , the synergistic increase in [ERK] phosphorylation was *dependent* on the cross talk between NMDA receptor associated synaptic adaptor protein PSD-95 and the mGluR5 linked adaptor protein Homer1b/c but not on the conventional signaling derived from NMDA receptors ( Ca2+ influx ) and mGluR5 ( intracellular Ca2+ release ) . Positive_regulation EPHB2 CA2 15689566 1371126 However , the mechanism by which *activates* [ERK] during LTP remains unknown . Positive_regulation EPHB2 CA2 15728661 1396303 Here , we examined the impact of cell energetics and mitochondrial function on the regulation of IL-1 induced signals and [ERK] *activation* in human gingival fibroblasts , cells that are important targets for IL-1 induced destruction of extracellular matrix in inflamed connective tissues . Positive_regulation EPHB2 CA2 15781976 1352642 Interestingly , acute application of Abeta or APP overexpression inhibits activity dependent regulation of several protein kinase pathways that require Ca2+ influx via NMDA receptors for activation , including *dependent* protein kinase II , protein kinase A , and [extracellular regulated kinases (Erk)] . Positive_regulation EPHB2 CA2 16151051 1499398 In this study , we tested the hypotheses that oxidants induce *mediated* phosphorylation of [ERK] and CREB , and that CREB is required for oxidant induced proliferation and apoptosis . Positive_regulation EPHB2 CA2 16407414 1554041 Cotreatment with the Rho kinase inhibitors Y-27632 and H1152 attenuated the CaR induced morphological change but not intracellular ( Ca2+ ( i ) ) mobilization or [ERK] *activation* , although transfection with a dominant negative RhoA binding protein also inhibited calcimimetic induced actin stress fiber assembly . Positive_regulation EPHB2 CA2 17472964 1750446 Moreover , *induced* activation of [ERK] through Rap1 and expression of loricrin were reduced in primary cultured nectin-1-/- keratinocytes ; Positive_regulation EPHB2 CA2 18573569 1946493 IgIII ( 270-280 ) -fragment-like H2N-DDSDEEN-COOH peptide modulates N-CAM expression via *dependent* [ERK] signaling during `` in vitro neurogenesis '' . Positive_regulation EPHB2 CA2 19432968 2084106 The signaling cascade connecting thrombin stimulation with Egr-1 gene expression required elevated levels of cytosolic , the activation of diacylgycerol dependent protein kinase C isoenzymes , and the *activation* of extracellular signal regulated protein kinase ( [ERK] ) . Positive_regulation EPHB2 CA2 19432968 2084110 This study shows that stimulus-transcription coupling in thrombin treated lung fibroblasts relies on the elevation of the intracellular and the *activation* of PKC and [ERK] . Positive_regulation EPHB2 CA2 23145787 2722829 IL ( interleukin ) -1 signalling in anchorage dependent cells involves focal-adhesion restricted and dependent Ras and [ERK] ( extracellular-signal regulated kinase ) *activation* that leads to MMP ( matrix metalloproteinase ) release and extracellular matrix remodelling . Positive_regulation EPHB2 CA2 8855261 388179 To investigate whether the *dependent* activation of mitogen activated protein kinases ( [ERK] , JNK , and p38 ) might be mediated by the CaM kinase cascade , we have transfected PC12 cells , which lack CaM-KIV , with constitutively active mutants of CaM kinase kinase and/or CaM-KIV ( CaM-KKc and CaM-KIVc , respectively ) . Positive_regulation EPHB2 CA2 9626657 511796 Signaling by the G protein coupled receptor GnRH was shown to include elevation of and *activation* of phospholipases , protein kinase C ( PKC ) and extra-cellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 CA2 9808472 545207 The sequential *activation* of [ERK] and Rsk2 by leads to the phosphorylation and transactivation of CREB . Positive_regulation EPHB2 CA2 9808472 545215 Interestingly , the *induced* nuclear translocation of [ERK] and Rsk2 to the nucleus requires protein kinase A (PKA) activation . Positive_regulation EPHB2 CADM1 19494363 2120568 These observations suggest that placental derived CLP/chymase is responsible for inducing endothelial inflammatory phenotypic changes possibly by upregulation of expressions , activation of cellular protease , and *induction* of [ERK] phosphorylation . Positive_regulation EPHB2 CADM2 19494363 2120566 These observations suggest that placental derived CLP/chymase is responsible for inducing endothelial inflammatory phenotypic changes possibly by upregulation of expressions , activation of cellular protease , and *induction* of [ERK] phosphorylation . Positive_regulation EPHB2 CADM3 19494363 2120565 These observations suggest that placental derived CLP/chymase is responsible for inducing endothelial inflammatory phenotypic changes possibly by upregulation of expressions , activation of cellular protease , and *induction* of [ERK] phosphorylation . Positive_regulation EPHB2 CADM4 19494363 2120567 These observations suggest that placental derived CLP/chymase is responsible for inducing endothelial inflammatory phenotypic changes possibly by upregulation of expressions , activation of cellular protease , and *induction* of [ERK] phosphorylation . Positive_regulation EPHB2 CALCA 17107942 1700423 EBP50 , a scaffolding protein that binds to the PDZ recognition domain of the PTH1R , impaired PTH but not isoproterenol or *induced* [ERK] activation . Positive_regulation EPHB2 CALCA 22792258 2628495 inhibited SDCP induced apoptosis in primary osteoclast cultures , *increased* Bcl-2 and [Erk] activity , and decreased Mcl-1 activity . Positive_regulation EPHB2 CALM3 10648884 662340 This finding indicates that the *dependent* activation of [ERK] and p38 kinase is involved in calcium induced c-fos expression . Positive_regulation EPHB2 CALM3 10718374 676661 Interactions of *dependent* protein kinases ( CaMK ) and [extracellular regulated kinase (ERK)] in monocyte adherence and TNFalpha production . Positive_regulation EPHB2 CALM3 11457825 850809 mu-Opioid receptor mediated [ERK] activation *involves* dependent epidermal growth factor receptor transactivation . Positive_regulation EPHB2 CALM3 11457825 850817 To test whether *contributes* to EGFR transactivation and [ERK] phosphorylation by MOR , we compared wild-type MOR with mutant K273A MOR , which binds CaM poorly , but couples normally to G proteins . Positive_regulation EPHB2 CALM3 15781976 1352643 Interestingly , acute application of Abeta or APP overexpression inhibits activity dependent regulation of several protein kinase pathways that require Ca2+ influx via NMDA receptors for activation , including *dependent* protein kinase II , protein kinase A , and [extracellular regulated kinases (Erk)] . Positive_regulation EPHB2 CALM3 15890671 1445580 Inhibition of ( using a dominant negative ) was *sufficient* to block GnRH induced [ERK] but not c-Jun N-terminal kinase activity activation . Positive_regulation EPHB2 CALM3 17268170 1765569 mediates house dust mite *induced* [ERK] activation and IL-8 production in human respiratory epithelial cells . Positive_regulation EPHB2 CALM3 17666046 1799175 dependent protein kinase II activity is *necessary* for nicotine induced [ERK] phosphorylation and neither cAMP dependent protein kinase or protein kinase C appear to be involved . Positive_regulation EPHB2 CALM3 18798281 2021045 Moreover , we found that inhibition of by W13 *blocked* both Arc transcription and [ERK] activation , revealing a Ca ( 2+ ) -independent function of CaM . Positive_regulation EPHB2 CALM3 19800889 2184025 From these results , it is suggested that PTTH stimulated [ERK] phosphorylation is only partially Ca ( 2+ ) - and *dependent* and that HNMPA- ( AM ) ( 3 ) -sensitive receptor tyrosine kinase is involved in activation of ERK phosphorylation by PTTH . Positive_regulation EPHB2 CALM3 22904641 2647461 Inhibitor studies suggest that BK-induced [ERK] activation requires phospholipase C and protein kinase C activities , and is Ca ( 2+ ) *dependent* . Positive_regulation EPHB2 CALM3 9774361 539716 inhibitors ( W7 and calmidazolium ) and tyrosine kinase inhibitors ( genistein and ST638 ) completely *blocked* [ERK] activation by Ang II and A23187 . Positive_regulation EPHB2 CALML3 19100683 2042019 This increase in [ Ca ( 2+ ) ] i was associated with *induced* cell apoptosis and [ERK] phosphorylation . Positive_regulation EPHB2 CAMK1 15034936 1223742 Further , the relationship between CaMK and ERK was connected by the finding that inhibitor also *blocked* magnolol induced [ERK] phosphorylation . Positive_regulation EPHB2 CAMK1 15689566 1371128 Both the pharmacological inhibitor of CaMKK , STO-609 , and dominant negative ( dnCaMKI ) , a downstream target of CaMKK , *blocked* neuronal NMDA receptor dependent [ERK] activation . Positive_regulation EPHB2 CAMK2B 18506790 1951842 We previously showed that Cd ( 2+ ) increased phosphorylation of [Erk] and CaMK-II , and activation *increased* cell death in an Erk independent manner . Positive_regulation EPHB2 CAMK2B 20432446 2268135 Low-dose heparin suppresses the ionomycin dependent phosphorylation of EGFR , c-Src , and Erk 1/2 , but not of CaMK-II , whereas inhibition of activated *reduces* phosphorylation of EGFR , c-Src , and [Erk] . Positive_regulation EPHB2 CAMK4 15034936 1223743 Further , the relationship between CaMK and ERK was connected by the finding that inhibitor also *blocked* magnolol induced [ERK] phosphorylation . Positive_regulation EPHB2 CAMKK1 15150258 1252309 Depolarization stimulated prolonged [ERK] and JNK activation that was *blocked* by the inhibitor , STO-609 ; Positive_regulation EPHB2 CAMKK1 15150258 1252314 However , activation of [ERK] by epidermal growth factor or carbachol were not *suppressed* by inhibition of , indicating specificity for this `` cross-talk . '' Positive_regulation EPHB2 CAMKK1 15689566 1371129 Both the pharmacological inhibitor of , STO-609 , and dominant negative CaMKI ( dnCaMKI ) , a downstream target of CaMKK , *blocked* neuronal NMDA receptor dependent [ERK] activation . Positive_regulation EPHB2 CAMKK2 15150258 1252310 Depolarization stimulated prolonged [ERK] and JNK activation that was *blocked* by the inhibitor , STO-609 ; Positive_regulation EPHB2 CAMKK2 15150258 1252315 However , activation of [ERK] by epidermal growth factor or carbachol were not *suppressed* by inhibition of , indicating specificity for this `` cross-talk . '' Positive_regulation EPHB2 CAMKK2 15689566 1371130 Both the pharmacological inhibitor of , STO-609 , and dominant negative CaMKI ( dnCaMKI ) , a downstream target of CaMKK , *blocked* neuronal NMDA receptor dependent [ERK] activation . Positive_regulation EPHB2 CAMP 17916212 1824869 Furthermore , *induced* phosphorylation of p38 and [ERK] . Positive_regulation EPHB2 CAMP 20163451 2287364 Vitamin C turned off phosphorylation of [ERK] that was *induced* by . Positive_regulation EPHB2 CAMP 20190140 2229238 As evidenced by the inhibitory effects of MAPK-specific inhibitors , hBD-2-4 and *activated* the phosphorylation of MAPKs p38 , [ERK] , and JNK that were required for IL-31 production and release . Positive_regulation EPHB2 CAMP 21685939 2538771 When analyzing the biological consequences of increased [ERK] activation *induced* by , we found that it resulted in enhanced migration and invasion of malignant cells in an IGF-1R/ß-arrestin manner , but did not affect cell proliferation . Positive_regulation EPHB2 CAMP 21732986 2476288 Furthermore , *induced* phosphorylation of [ERK] and the ERK inhibitor PD98059 blocked the inhibitory effect of LL-37 on apoptosis . Positive_regulation EPHB2 CAPN1 23467348 2750037 BDNF treatment increased phosphorylation of both Akt and [ERK] , but only the effect on Akt was *blocked* by inhibition . Positive_regulation EPHB2 CAPN10 23467348 2750038 BDNF treatment increased phosphorylation of both Akt and [ERK] , but only the effect on Akt was *blocked* by inhibition . Positive_regulation EPHB2 CAPN11 23467348 2750039 BDNF treatment increased phosphorylation of both Akt and [ERK] , but only the effect on Akt was *blocked* by inhibition . Positive_regulation EPHB2 CAPN12 23467348 2750036 BDNF treatment increased phosphorylation of both Akt and [ERK] , but only the effect on Akt was *blocked* by inhibition . Positive_regulation EPHB2 CAPN13 23467348 2750047 BDNF treatment increased phosphorylation of both Akt and [ERK] , but only the effect on Akt was *blocked* by inhibition . Positive_regulation EPHB2 CAPN14 23467348 2750048 BDNF treatment increased phosphorylation of both Akt and [ERK] , but only the effect on Akt was *blocked* by inhibition . Positive_regulation EPHB2 CAPN15 23467348 2750035 BDNF treatment increased phosphorylation of both Akt and [ERK] , but only the effect on Akt was *blocked* by inhibition . Positive_regulation EPHB2 CAPN2 23467348 2750040 BDNF treatment increased phosphorylation of both Akt and [ERK] , but only the effect on Akt was *blocked* by inhibition . Positive_regulation EPHB2 CAPN3 23467348 2750041 BDNF treatment increased phosphorylation of both Akt and [ERK] , but only the effect on Akt was *blocked* by inhibition . Positive_regulation EPHB2 CAPN5 23467348 2750042 BDNF treatment increased phosphorylation of both Akt and [ERK] , but only the effect on Akt was *blocked* by inhibition . Positive_regulation EPHB2 CAPN6 23467348 2750043 BDNF treatment increased phosphorylation of both Akt and [ERK] , but only the effect on Akt was *blocked* by inhibition . Positive_regulation EPHB2 CAPN7 23467348 2750044 BDNF treatment increased phosphorylation of both Akt and [ERK] , but only the effect on Akt was *blocked* by inhibition . Positive_regulation EPHB2 CAPN8 23467348 2750045 BDNF treatment increased phosphorylation of both Akt and [ERK] , but only the effect on Akt was *blocked* by inhibition . Positive_regulation EPHB2 CAPN9 23467348 2750046 BDNF treatment increased phosphorylation of both Akt and [ERK] , but only the effect on Akt was *blocked* by inhibition . Positive_regulation EPHB2 CASP1 10749152 681113 and ( e ) a broad-spectrum inhibitor Z-Asp-CH2-DCB *inhibited* CH-11 induced [ERK] phosphorylation , cell cycle progression , and apoptosis . Positive_regulation EPHB2 CASP1 12807432 1101928 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Positive_regulation EPHB2 CASP10 10749152 681114 and ( e ) a broad-spectrum inhibitor Z-Asp-CH2-DCB *inhibited* CH-11 induced [ERK] phosphorylation , cell cycle progression , and apoptosis . Positive_regulation EPHB2 CASP10 12807432 1101929 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Positive_regulation EPHB2 CASP12 10749152 681124 and ( e ) a broad-spectrum inhibitor Z-Asp-CH2-DCB *inhibited* CH-11 induced [ERK] phosphorylation , cell cycle progression , and apoptosis . Positive_regulation EPHB2 CASP12 12807432 1101939 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Positive_regulation EPHB2 CASP14 10749152 681115 and ( e ) a broad-spectrum inhibitor Z-Asp-CH2-DCB *inhibited* CH-11 induced [ERK] phosphorylation , cell cycle progression , and apoptosis . Positive_regulation EPHB2 CASP14 12807432 1101930 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Positive_regulation EPHB2 CASP16 10749152 681125 and ( e ) a broad-spectrum inhibitor Z-Asp-CH2-DCB *inhibited* CH-11 induced [ERK] phosphorylation , cell cycle progression , and apoptosis . Positive_regulation EPHB2 CASP16 12807432 1101940 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Positive_regulation EPHB2 CASP2 10749152 681116 and ( e ) a broad-spectrum inhibitor Z-Asp-CH2-DCB *inhibited* CH-11 induced [ERK] phosphorylation , cell cycle progression , and apoptosis . Positive_regulation EPHB2 CASP2 12807432 1101931 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Positive_regulation EPHB2 CASP3 10749152 681117 and ( e ) a broad-spectrum inhibitor Z-Asp-CH2-DCB *inhibited* CH-11 induced [ERK] phosphorylation , cell cycle progression , and apoptosis . Positive_regulation EPHB2 CASP3 12807432 1101932 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Positive_regulation EPHB2 CASP3 15040837 1224380 The anti-apoptotic effect of calbindin-D28k involves inhibition of glucocorticoid induced activation as well as [ERK] *activation* . Positive_regulation EPHB2 CASP3 15547704 1338345 Functional assays using chemical inhibitors demonstrated that the phosphorylation of [ERK] was mediated by reactive oxygen species in an Raf-1 independent manner and *required* the activation of . Positive_regulation EPHB2 CASP3 15935058 1414833 In the present study we used western blotting and immunocytochemistry to investigate the effects of this FGF-2 treatment upon the activation of the extracellular signal regulated kinase ( [ERK] ) pathway , the amounts and distribution of Bcl-2 family proteins , and the *activation* of . Positive_regulation EPHB2 CASP3 15964118 1428216 In addition , the malvidin treatment significantly increased the p38 kinase expression and *inhibited* the [ERK] activity , and the effects of malvidin on activation were blocked , respectively , by the ERK and p38 inhibitors . Positive_regulation EPHB2 CASP3 16932918 1708762 Thus , although mechanisms other than caspase dependent apoptosis may be involved , apoptotic process seems to take place in the genesis of toxicity of acrylamide in SH-SY5Y cells through [ERK] pathway and *activation* of . Positive_regulation EPHB2 CASP3 18623086 1941799 Moreover , *induced* [ERK] activation . Positive_regulation EPHB2 CASP3 18623086 1941808 In summary , *induces* [ERK] activation through a ceramide-dependant , protease activity independent mechanism , which represents a novel role of caspase-3 in tumor metastasis . Positive_regulation EPHB2 CASP3 20077196 2178351 Fifty micromolar HQ markedly increased phosphorylation of [ERK] and *activation* of , followed by PARP cleavage . Positive_regulation EPHB2 CASP3 20444938 2294133 Ghrelin significantly inhibited apoptotic cell death of neurons and oligodendrocytes , release of mitochondrial cytochrome c , and activation of after moderate contusion SCI. Ghrelin also significantly *increased* the level of phosphorylated [ERK] but decreased the level of phosphorylated p38MAPK . Positive_regulation EPHB2 CASP3 21315038 2393338 Reduction of MC3T3 cell surface cholesterol dramatically inhibited TNFR1 mediated AKT phosphorylation , while did not affect the degradation of I?Ba , *activation* of [ERK] or p38 , and processing of induced by TNF-a . Positive_regulation EPHB2 CASP3 21315038 2393343 therefore our results suggest that lipid raft is essential for TNFR1 mediated AKT phosphorylation , but is dispensable for TNFR1 mediated degradation of I?Ba , *activation* of [ERK] or p38 and processing of . Positive_regulation EPHB2 CASP3 23570653 2870235 Subsequent tumor tissue analysis showed that silibinin treatment induced a decrease in Ki-67 positive cells , an increase in transferase mediated dUTP nick end labeling ( TUNEL ) -positive cells , *activation* of , and inhibition of [p-ERK] and p-Akt . Positive_regulation EPHB2 CASP4 10749152 681118 and ( e ) a broad-spectrum inhibitor Z-Asp-CH2-DCB *inhibited* CH-11 induced [ERK] phosphorylation , cell cycle progression , and apoptosis . Positive_regulation EPHB2 CASP4 12807432 1101933 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Positive_regulation EPHB2 CASP5 10749152 681119 and ( e ) a broad-spectrum inhibitor Z-Asp-CH2-DCB *inhibited* CH-11 induced [ERK] phosphorylation , cell cycle progression , and apoptosis . Positive_regulation EPHB2 CASP5 12807432 1101934 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Positive_regulation EPHB2 CASP6 10749152 681120 and ( e ) a broad-spectrum inhibitor Z-Asp-CH2-DCB *inhibited* CH-11 induced [ERK] phosphorylation , cell cycle progression , and apoptosis . Positive_regulation EPHB2 CASP6 12807432 1101935 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Positive_regulation EPHB2 CASP7 10749152 681121 and ( e ) a broad-spectrum inhibitor Z-Asp-CH2-DCB *inhibited* CH-11 induced [ERK] phosphorylation , cell cycle progression , and apoptosis . Positive_regulation EPHB2 CASP7 12807432 1101936 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Positive_regulation EPHB2 CASP8 10749152 681122 and ( e ) a broad-spectrum inhibitor Z-Asp-CH2-DCB *inhibited* CH-11 induced [ERK] phosphorylation , cell cycle progression , and apoptosis . Positive_regulation EPHB2 CASP8 12807432 1101937 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Positive_regulation EPHB2 CASP8 16129431 1461143 Interestingly , the enzymatic function of is not *required* for TNF induced [ERK] activation . Positive_regulation EPHB2 CASP9 10749152 681123 and ( e ) a broad-spectrum inhibitor Z-Asp-CH2-DCB *inhibited* CH-11 induced [ERK] phosphorylation , cell cycle progression , and apoptosis . Positive_regulation EPHB2 CASP9 12807432 1101938 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Positive_regulation EPHB2 CASP9 20077196 2178352 Fifty micromolar HQ markedly increased phosphorylation of [ERK] and *activation* of , followed by PARP cleavage . Positive_regulation EPHB2 CASR 12191970 980660 The kinetics of activation of the L125P mutant receptor expressed in HEK-293 cells , assessed by measuring *stimulated* changes in intracellular Ca ( 2+ ) and [ERK] activity , showed a dramatic reduction in the EC ( 50 ) for extracellular Ca ( 2+ ) compared with the wild-type and a loss-of-function mutant CaSR ( I40F ) . Positive_regulation EPHB2 CASR 23269116 2758016 Exposure of intestinal epithelia to the EDGP analog PA stimulates *dependent* [ERK] phosphorylation and epithelial mediated collagen lattice contraction . Positive_regulation EPHB2 CAST 18027879 1866887 A that partially rescued FAK degradation also *prevented* low rigidity induced [ERK] phosphorylation . Positive_regulation EPHB2 CAT 12682429 1077798 However , exogenously added SOD1 and heat inactivated *had* no effect on either toxicity or sustained [ERK] phosphorylation . Positive_regulation EPHB2 CAT 16819299 1581467 We conclude that CAGE enhances the motility of cancer cells by activating [ERK] and p38 MAPK , *inducing* activity , and reducing ROS levels . Positive_regulation EPHB2 CAV1 12529448 1048807 Removal of and VEGFR-2 from caveolae by cholesterol depletion resulted in an increase in both basal and VEGF induced phosphorylation of VEGFR-2 , but *led* to the inhibition of VEGF induced [ERK] activation and endothelial cell migration , suggesting that localization of VEGFR-2 to these domains is crucial for VEGF mediated signaling . Positive_regulation EPHB2 CAV1 15072971 1232656 Taken together , caveolin in caveolae may keep [ERK] inactive , but when caveolin is translocated to noncaveolar sites in response to stretch stress , *mediates* stretch induced ERK activation through an association with beta1-integrins/Fyn/Shc . Positive_regulation EPHB2 CAV1 17905724 1866314 We conclude that , perhaps via its ability to scaffold key signaling components , is *essential* for NMDAR localization to neuronal membrane rafts , NMDAR/Src tyrosine kinase [family/ERK] signaling , and protection of neurons from ischemic injury and cell death . Positive_regulation EPHB2 CAV1 20021823 2175446 Western blotting results showed that overexpression of *reduced* the phosphorylation of EGFR , c-Raf , Mek and [Erk] while did not affect the activity of p38 and SAPK/JNK . Positive_regulation EPHB2 CAV1 22230296 2569221 Estrogen- and xenoestrogen induced [ERK] signaling in pituitary tumor cells *involves* estrogen receptor-a interactions with G protein-ai and . Positive_regulation EPHB2 CAV1 23428975 2744223 *induced* phosphorylation of JNK and [ERK] , but not Stat3 in HGFs . Positive_regulation EPHB2 CAV1 23428975 2744228 Furthermore , increased proMMP-1 and VEGF secretion in HGFs , and the VEGF secretion was statistically *suppressed* by JNK inhibitor SP600125 , but not [ERK] inhibitor PD98059 . Positive_regulation EPHB2 CAV1 25002533 2952818 The interaction between KSR1 and is *essential* for optimal activation of [ERK] as a KSR1 mutant unable to interact with caveolin-1 does not efficiently mediate growth factor induced ERK activation at the early stages of pathway activation . Positive_regulation EPHB2 CAV1 25002533 2952820 These data show that is *necessary* for optimal KSR1 dependent [ERK] activation by growth factors and oncogenic Ras . Positive_regulation EPHB2 CAV2 12529448 1048808 Removal of and VEGFR-2 from caveolae by cholesterol depletion resulted in an increase in both basal and VEGF induced phosphorylation of VEGFR-2 , but *led* to the inhibition of VEGF induced [ERK] activation and endothelial cell migration , suggesting that localization of VEGFR-2 to these domains is crucial for VEGF mediated signaling . Positive_regulation EPHB2 CAV2 15072971 1232657 Taken together , caveolin in caveolae may keep ERK inactive , but when caveolin is translocated to noncaveolar sites in response to stretch stress , *mediates* stretch induced [ERK] activation through an association with beta1-integrins/Fyn/Shc . Positive_regulation EPHB2 CAV3 12529448 1048809 Removal of and VEGFR-2 from caveolae by cholesterol depletion resulted in an increase in both basal and VEGF induced phosphorylation of VEGFR-2 , but *led* to the inhibition of VEGF induced [ERK] activation and endothelial cell migration , suggesting that localization of VEGFR-2 to these domains is crucial for VEGF mediated signaling . Positive_regulation EPHB2 CAV3 15072971 1232658 Taken together , in caveolae may keep ERK inactive , but when caveolin is translocated to noncaveolar sites in response to stretch stress , caveolin *mediates* stretch induced [ERK] activation through an association with beta1-integrins/Fyn/Shc . Positive_regulation EPHB2 CBL 19508871 2103051 Moreover , overexpression of significantly *suppressed* [ERK] activation , and Cbl-b ( DN ) strongly enhanced both ERK and Akt activation . Positive_regulation EPHB2 CBL 20177738 2272383 On the other hand , [ERK] activity was *enhanced* by , and the ERK inhibitor PD98059 reversed Cbl-b enhanced apoptosis . Positive_regulation EPHB2 CBL 24466333 2907808 decreased downstream ERK activation by RETMEN2A and co-expression of Enigma *blocked* the Cbl-c mediated decrease in [ERK] activation . Positive_regulation EPHB2 CBR1 23818935 2808361 inhibited the level of inducible nitric oxide synthase (iNOS) and cyclooxygenase-(COX-)2 proteins , and it *activated* p38-MAPK , extracellular signal related kinases ( [ERK] ) , and NF- ? B in LPS stimulated RAW264.7 macrophages . Positive_regulation EPHB2 CCBE1 24523457 2918834 Moreover , Vegfc- and Vegfr3 dependent [Erk] signaling is *impaired* in the absence of . Positive_regulation EPHB2 CCDC134 18087676 1862365 Functional investigation reveals that overexpression of and its purified protein significantly *inhibit* transcriptional activity of Elk1 and phosphorylation of [Erk] and JNK/SAPK but not p38 MAPK . Positive_regulation EPHB2 CCDC88A 23370007 2747790 conversely , forced expression of *up-regulated* the [ERK] activation by Pb or serum in both Cys65-redox activity dependent and independent manners . Positive_regulation EPHB2 CCK 11030434 740130 The *dependent* [ERK] stimulation is sensitive to wortmannin an inhibitor of phosphoinositide 3-kinases (PI3Ks) indicating the involvement of PI3K activity . Positive_regulation EPHB2 CCK 11030434 740131 Surprisingly , different catalytically inactive mutants of the G protein-sensitive PI3Kgamma did not affect [ERK] stimulation *induced* by , whereas a dominant negative mutant of the regulatory p85 subunit induced significant inhibition of CCK dependent ERK activity . Positive_regulation EPHB2 CCK 11030434 740132 In addition , protein kinase C ( PKC ) -dependent signaling pathways contribute to CCK ( B ) -mediated MAP kinase signaling as shown by inhibition of *induced* [ERK] activation by the PKC inhibitor bisindolylmaleimide . Positive_regulation EPHB2 CCK 22461029 2612916 When signaling pathways were evaluated , stimulation *increased* c-Jun expression , JNK and [ERK] activity , and AP-1 activation . Positive_regulation EPHB2 CCL2 11154209 770677 Pertussis toxin , a blocker of Go/Gi proteins , abrogated *induced* [ERK] activation , but was without any effect on SAPK1/JNK1 and SAPK2/p38 activation . Positive_regulation EPHB2 CCL2 12393099 1007817 *induces* activation of MAP-kinases [ERK] , JNK and p38 MAPK in human endothelial cells . Positive_regulation EPHB2 CCL2 12689946 1106082 ) , eotaxin-3 does not *trigger* intracellular calcium mobilization , enzyme release , or phosphorylation of the mitogen activated protein (MAP) kinase [ERK] and induces a weak chemotaxis in monocytes . Positive_regulation EPHB2 CCL2 12920215 1130942 We show that [ERK] *activation* by involves heterotrimeric Gi protein subunits , protein kinase C , phosphoinositide-3-kinase , and Ras . Positive_regulation EPHB2 CCL2 12920215 1130946 In addition , we find that internalization of CCR2B itself is not necessary for efficient *induced* activation of [ERK] , although a dynamin mutant partially inhibits ERK stimulation . Positive_regulation EPHB2 CCL2 19211873 2034038 Blocking TRPC channels and specific downregulation of TRPC channels 1 and 5 resulted in suppression of induced [ERK/CREB] *activation* but not Akt/NF-kappaB activation . Positive_regulation EPHB2 CCL2 19573621 2136739 Such oxLDL elicited foamy-like phenotype was a pertussis toxin-sensitive process that depended on a paracrine activity of endogenous and *activation* of [ERK] . Positive_regulation EPHB2 CCL2 21878744 2516031 In resveratrol treated monocytic cells , *induced* [Erk] phosphorylation downstream of CCR2 receptor was dose-dependently inhibited , as observed by Western blot analysis . Positive_regulation EPHB2 CCL2 23352833 2758501 On the other hand , phosphorylation of [ERK] *induced* by VEGF and was inhibited by PF-4 , Mig and IP-10 . Positive_regulation EPHB2 CCL2 23397250 2787078 IL-33 *induces* , TNF-a and nitric oxide release through phosphorylation of [ERK] in mouse astrocytes . Positive_regulation EPHB2 CCL2 23916475 2878313 Together , these findings suggest that stimulation of spinal microglia P2Y6 receptors *induce* the production of through either PLC mediated [ERK] or p38 phosphorylation and the subsequent activation of NF-?B . Positive_regulation EPHB2 CCL21 22438908 2573466 Coimmunoprecipitation further confirmed that there was an interaction between [p-ERK] and bcl-2 , bax , or caspase-3 , particularly in the *presence* of . Positive_regulation EPHB2 CCL23 19265684 2055563 Furthermore , VEGF induced [ERK] phosphorylation was *stimulated* by . Positive_regulation EPHB2 CCL26 12689946 1106083 CCL2 ) , does not *trigger* intracellular calcium mobilization , enzyme release , or phosphorylation of the mitogen activated protein (MAP) kinase [ERK] and induces a weak chemotaxis in monocytes . Positive_regulation EPHB2 CCL5 21381021 2404421 In addition , *augmented* the CXCR4 ligand-driven [ERK] phosphorylation in mononuclear cells . Positive_regulation EPHB2 CCNB1 20664969 2298219 Immunoblot analysis demonstrated that oridonin treatment increased expression levels of p-JNK , p-p38 , p-p53 and p21 , elevated the level of ( Tyr15 ) complex , and *inhibited* the expression of [p-ERK] . Positive_regulation EPHB2 CCND1 10512860 651411 Cell attachment to fibronectin or anti-alpha5beta1 integrin is sufficient to sustain the [ERK] signal and to *induce* in growth factor treated cells . Positive_regulation EPHB2 CCND1 10939590 721017 Although V12Ras was able to stimulate [ERK] phosphorylation and *induce* expression in the absence of androgen , it was not sufficient to promote androgen independent cell cycle progression . Positive_regulation EPHB2 CCND1 11004713 734990 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping [ERK-MAPK] activation and c-Fos and *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation EPHB2 CCND1 11804875 903400 IFN-gamma does not interfere with the effects of HGF on either [ERK] activation or *induction* ; Positive_regulation EPHB2 CCND1 12816758 1157187 Transient [ERK] activation and subsequent *induction* were observed on adding 10 microM ZnCl2 in MSSM in the presence of cell proliferation . Positive_regulation EPHB2 CCND1 12816758 1157190 Moreover , this [ERK] activation and and p21 ( Cip/WAF1 ) *induction* were abolished by PD-98059 pretreatment . Positive_regulation EPHB2 CCND1 12816758 1157197 The differential regulations of cell growth , [ERK] activities , and and p21 ( Cip/WAF1 ) *inductions* were also observed in serum enriched medium containing higher zinc concentrations . Positive_regulation EPHB2 CCND1 19935697 2210091 The expression of *required* both EGFR mediated [ERK] and AKT activation . Positive_regulation EPHB2 CCND1 22579115 2609549 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated and Cyclin B1 proteins as well as *activation* of PI3K/Akt and [Raf/MEK/ERK] , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation EPHB2 CCND1 9537433 497548 Furthermore , in 25 of 26 cases of HCC which genomic DNA was available , 22 cases without genomic DNA amplification exhibited positive correlation , not only between protein expression of c-Fos and , but also between [MAPK/ERK] *activation* and cyclin D1 expression . Positive_regulation EPHB2 CCR1 17464174 1731713 p38 MAPK and [ERK] activation by 9-cis-retinoic acid *induces* chemokine receptors and CCR2 expression in human monocytic THP-1 cells . Positive_regulation EPHB2 CCR1 21403648 2447984 inhibition *reduced* [ERK] phosphorylation and restored both osterix and osteocalcin expression in the presence of CCL3 . Positive_regulation EPHB2 CCR2 17464174 1731714 p38 MAPK and [ERK] activation by 9-cis-retinoic acid *induces* chemokine receptors CCR1 and expression in human monocytic THP-1 cells . Positive_regulation EPHB2 CCR7 11700037 878460 Induction of expression in thymocytes *requires* both [ERK] signal and Ca ( 2+ ) signal . Positive_regulation EPHB2 CCR7 23449735 2787369 Finally , primed eosinophils stimulated with CCL19 or CCL21 exhibited increased phosphorylation of [ERK] in *response* to both ligands . Positive_regulation EPHB2 CD14 16879219 1593837 Lipopolysaccharide induced decreased protein S expression in liver cells is mediated by [MEK/ERK] signaling and NFkappaB *activation* : involvement of membrane bound and toll-like receptor-4 . Positive_regulation EPHB2 CD14 16879219 1593855 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by [MEK/ERK] signaling and NFkappaB activation and that membrane bound and TLR-4 are *involved* in this mechanism . Positive_regulation EPHB2 CD151 20581856 2285573 Activation of [ERK] was *dependent* on the formation of complexes . Positive_regulation EPHB2 CD151 22684562 2611663 Taken together , it was concluded that CD151 promotes the proliferation and migration of PC3 cells through the formation of complex and the *activation* of phosphorylated [ERK] . Positive_regulation EPHB2 CD2 10979964 729836 Signaling via LAT ( linker for T-cell activation ) and Syk/ZAP70 is required for [ERK] *activation* and NFAT transcriptional activation following stimulation . Positive_regulation EPHB2 CD209 16434485 1554430 ligation on dendritic cells *results* in [ERK] and PI3K activation and modulates cytokine production . Positive_regulation EPHB2 CD209 23378214 2793793 Treatment of the cells with antibody to *results* in inhibition of the E2 binding as well as the E2-induced MEK and [ERK] activation . Positive_regulation EPHB2 CD274 18941206 1978141 NAC blocked the activation of JNK and down-regulation of [ERK] , but both z-VAD-fmk ( N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone ) and ZB4 did not *inhibit* JNK activation of stimulation . Positive_regulation EPHB2 CD28 11085983 810046 Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and *induced* [Erk] and Jnk activation . Positive_regulation EPHB2 CD28 14550257 1152591 PI3-kinase and Erk1/2 were shown to potentially regulate primary T-cell activation and subsequent proliferation via both AILIM/ICOS- or mediated *costimulation* and the [Erk] signaling cascade was essential for this proliferation induction and also for IL-2 production . Positive_regulation EPHB2 CD28 8525474 336514 Using the T cell leukemic cell line Jurkat as a model for T cell activation , we demonstrate that cross linking using monoclonal antibodies *causes* tyrosine phosphorylation and activation of MAP [kinase/ERK] . Positive_regulation EPHB2 CD38 11689561 896334 Moreover , in these cells , or anti-CD3 stimulation *leads* to protein kinase B/Akt and [Erk] activation , suggesting that the CD3-zeta-immunoreceptor tyrosine based activation motifs are not required for CD38 signaling in T cells . Positive_regulation EPHB2 CD38 11689561 896338 Consistent with this , cholesterol depletion with methyl-beta-cyclodextrin substantially reduces CD38 mediated Akt activation while enhancing mediated [Erk] *activation* . Positive_regulation EPHB2 CD38 20570673 2302879 Indeed , is enzymatically active in both exosomes and MR , and CD38 ligation *induces* Akt/PKB and [Erk] activation , which is accompanied by increased translocation of CD38 into MR. In conclusion , the present study indicates that CD38 localizes to MR , where it promotes cell signaling , and it is exported out of the cells through the exosome mediated exocytic pathway , where it may act as an intercellular messenger . Positive_regulation EPHB2 CD3D 15307176 1284831 CD46 enhanced induced tyrosine phosphorylation of CD3zeta and ZAP-70 , as well as the *activation* of the [ERK] , JNK , and p38 , but did not modify intracellular calcium . Positive_regulation EPHB2 CD3E 15307176 1284832 CD46 enhanced *induced* tyrosine phosphorylation of CD3zeta and ZAP-70 , as well as the activation of the [ERK] , JNK , and p38 , but did not modify intracellular calcium . Positive_regulation EPHB2 CD3G 15307176 1284833 CD46 enhanced *induced* tyrosine phosphorylation of CD3zeta and ZAP-70 , as well as the activation of the [ERK] , JNK , and p38 , but did not modify intracellular calcium . Positive_regulation EPHB2 CD4 12594266 1060828 Stimulation of ( + ) T cells with a high affinity peptide *resulted* in sustained [Erk] activation and Th1 differentiation . Positive_regulation EPHB2 CD4 12594849 1061096 H4/ICOS mediated activation of JNK , but not [ERK] or p38 , is partially *dependent* on the expression of by the cells , whereas H4/ICOS costimulation is partially independent on CD28 expression . Positive_regulation EPHB2 CD40 10586053 571649 We and others previously observed that IgM and stimulation in murine B cells *resulted* in activation of extracellular signal regulated kinase ( [ERK] ) , a subfamily of mitogen activated protein kinase . Positive_regulation EPHB2 CD40 10586053 571650 These results support the notion that [ERK] could mediate different effector functions in B cells upon *stimulation* with IgM and . Positive_regulation EPHB2 CD40 11222496 787585 Engagement of in both monocytes and THP1 cells *led* to the rapid and transient activation of the extracellular signal regulated kinases ( [ERK] ) 1 and 2 , and to low levels of JNK activation . Positive_regulation EPHB2 CD40 12689928 1106073 Activation of CD30 , , and receptor activator of nuclear kappabeta ( RANK ) receptors in HD cells by their respective ligands *increased* [ERK] phosphorylation above the basal level and promoted HD cell survival . Positive_regulation EPHB2 CD40 12881420 1116077 The selective signaling defect resulting from the inactivation of Tpl2 allowed us to demonstrate that mediated [ERK] *activation* contributes to immunoglobulin production but is not essential for B-cell proliferation . Positive_regulation EPHB2 CD40 14764680 1207239 IL-10 significantly inhibited induced *activation* of the [ERK] , p38 MAPK , and NF-kappaB pathways ; Positive_regulation EPHB2 CD40 16585179 1544130 In contrast , CD40-resistant lines showed no constitutive activation of ERK and no increase in [ERK] activity in *response* to stimulation . Positive_regulation EPHB2 CD40 18481208 1840574 The differential requirement for ROS in the *activation* of [ERK] , JNK , p38 , and Akt by the BCR , , and CXCR4 likely reflects the multiplicity of upstream activators for each of these kinases , only some of which may be regulated in a redox dependent manner . Positive_regulation EPHB2 CD40 18725396 1984986 We found that in CB B cells *activation* of extracellular signal regulated kinase ( [ERK] ) and p38 following ligation of but not of the B-cell antigen receptor (BCR) was inefficient . Positive_regulation EPHB2 CD40 18725396 1984994 mediated *activation* of [ERK] and p38 was also minimal in these B cells of CB . Positive_regulation EPHB2 CD40 22711886 2621439 Moreover , consistent with previous results , we also show that TRAF2 was required for efficient JNK and [ERK] activation in *response* to engagement . Positive_regulation EPHB2 CD40 8759724 377936 ligation *results* in protein kinase C-independent activation of [ERK] and JNK in resting murine splenic B cells . Positive_regulation EPHB2 CD40 8759724 377937 however , no effect was seen on *mediated* activation of [ERK] or c-Jun NH2-terminal kinase , suggesting that the BCR and CD40 differentially utilize protein kinase C to couple with these signaling pathways . Positive_regulation EPHB2 CD40 9432981 482446 The deletion mutant of TRAF6 lacking the NH2-terminal domain acted as a dominant negative mutant to suppress [ERK] *activation* by full-length and suppress prominently ERK activation by a deletion mutant of CD40 only containing the binding site for TRAF6 in the cytoplasmic tail ( CD40 delta 246 ) . Positive_regulation EPHB2 CD40 9432981 482449 Transient expression of the dominant negative H-Ras significantly suppressed [ERK] *activation* by full-length , but marginally suppressed ERK activation by CD40 delta 246 , compatible with the possibility that TRAF6 is a major transducer of ERK activation by CD40 delta 246 , whose activity is mediated by a Ras independent pathway . Positive_regulation EPHB2 CD40 9498749 490593 Finally , agents that elevate cAMP , causing protein kinase A-mediated inhibition of Raf-1 , inhibited activation of ERK in response to mIg cross linking , but had no affect on [ERK] activation in *response* to or Jun N-terminal kinase activation by signals through either receptor . Positive_regulation EPHB2 CD40LG 23072591 2706617 Similarly , *induced* [p-ERK] and p-p38 were also significantly reduced in lymphoma B cells , whereas p-p65 ( NF-?B ) was equal to that of normal B cells . Positive_regulation EPHB2 CD44 20956971 2389469 The results raise the novel idea that the EGFR may activate [Raf-MEK-ERK] signaling in *response* to the binding of HA to . Positive_regulation EPHB2 CD44 21283538 2387783 It was reported that MIF induced rapid [ERK] activation *requires* its co-receptor . Positive_regulation EPHB2 CD69 10671222 666697 Here we report that engagement *leads* to the activation of extracellular signal regulated kinase ( [ERK] ) enzymes belonging to the MAPK family , and that this event is required for CD69 mediated cell degranulation . Positive_regulation EPHB2 CD69 10898494 712061 Here , we analyzed the effects of Vav on three known downstream targets of Ras , i. e. *activation* of [ERK] and NFAT , and up-regulation of the activation antigen . Positive_regulation EPHB2 CD69 20658220 2316952 To distinguish between the activation signalling and the death inducing pathway downstream of Fas , we generated a novel T cell line expressing a chimeric hCD8-FasC protein and found that stimulation with the anti-CD8 antibodies induced tyrosine phosphorylation of TCR-proximal proteins , *activation* of [Raf-1/ERK] , p38 and JNK , and increased expression of , Fas , and Fas ligand . Positive_regulation EPHB2 CD72 11466342 839903 Although both and BCR *induced* Btk dependent [ERK] activation , CD72 mediated proliferation is more resistant to blocking of ERK activity than that of BCR , as shown by the proliferation response of B cells treated with PD98059 and dibutyryl cAMP , agents that inhibit ERK activity . Positive_regulation EPHB2 CD79A 10438726 635004 Because extracellular signal regulated kinases ( ERKs ) couple upstream signaling pathways to gene activation and are activated by B-cell antigen receptor (BCR) signaling , we examined whether CD22 ligation also activated ERKs and/or modified induced [ERK] *activation* . Positive_regulation EPHB2 CD79A 11726515 884443 In vivo expression of a Grb2 mutant where Tyr209 was changed to phenylalanine enhanced induced [ERK] *activation* and fibroblast transformation , and potentiated and prolonged Grb2 mediated activation of Ras , mitogen activated protein kinase and c-Jun N-terminal kinase in response to EGF stimulation . Positive_regulation EPHB2 CD79A 11823472 922653 We report that inhibition of mitogen activated protein kinase/extracellular signal regulated kinase kinase ( MEK)-1/2 blocked induced *activation* of extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 CD79A 12095152 960711 In contrast , cross linking *resulted* in [ERK] activation , although the activation in quiescent cells was case dependent . Positive_regulation EPHB2 CD79A 12411479 1010823 Loss of Raf-1 has no effect on BCR mediated ERK activation , whereas B-Raf-deficient DT40 cells display a reduced basal [ERK] activity as well as a shortened mediated ERK *activation* . Positive_regulation EPHB2 CD79A 12411479 1010828 Our study shows that mediated [ERK] *activation* involves a cooperation of both B-Raf and Raf-1 , which are activated specifically in a temporally distinct manner . Positive_regulation EPHB2 CD79A 12444544 1017450 These data implicate the Src kinase family in Stat5 and [Erk] *activation* downstream of , and identify myeloid-specific Src kinases as potential drug targets in CML . Positive_regulation EPHB2 CD79A 12509924 1027510 ( 1 ) *induces* the phosphorylation of [ERK] , DNA synthesis and proliferation of HMC , and the effects of IgA ( 1 ) from patients with IgAN are stronger than that from healthy persons . Positive_regulation EPHB2 CD79A 12904304 1150327 Preventing Rap activation had no effect on *induced* activation of [ERK] . Positive_regulation EPHB2 CD79A 15569688 1368315 With respect to MAPK activation , HSH2 was not observed to alter the activation of [ERK] or p38 in *response* to ligation , but it does significantly potentiate JNK activation . Positive_regulation EPHB2 CD79A 15749869 1379670 B cell receptor (BCR) cross-talk : CD40 engagement enhances *induced* [ERK] activation . Positive_regulation EPHB2 CD79A 16585562 1544193 Intracellular calcium signaling and [ERK] activation in *response* to engagement were also proportionately decreased and delayed , respectively , with stepwise reduction of plcgamma2 dosage in a BLNK ( null ) background . Positive_regulation EPHB2 CD79A 17522256 1751328 Coligation of this fusion protein with the B cell receptor (BCR) inhibited mediated calcium mobilization , intracellular tyrosine phosphorylation , and [Erk] kinase *activation* . Positive_regulation EPHB2 CD79A 17640867 1787654 The overexpression of LPXN in mouse A20 B lymphoma cells led to the suppression of induced *activation* of JNK , p38 MAPK , and , to a lesser extent , Akt , but not [ERK] and NFkappaB , suggesting that LPXN can selectively repress BCR signaling . Positive_regulation EPHB2 CD79A 17656488 1793747 Using Western blotting and phospho-specific flow cytometry , we now show that the kinetics and magnitude of *mediated* activation of [ERK-MAPK] are markedly attenuated in WEHI-231 cells and splenic B cells that have been exposed to low and nontoxic burdens of Hg ( +2 ) . Positive_regulation EPHB2 CD79A 17724683 1801602 *mediated* phosphorylation of Akt and [Erk] is sensitive to the PI3K catalytic inhibitor wortmannin in both marginal zone ( MZ ) and follicular ( FO ) cells . Positive_regulation EPHB2 CD79A 18448454 1921239 It was previously shown that Bam32-deficient mice have defects in various aspects of B cell activation including *induced* [Erk] activation , BCR induced proliferation and T-independent antibody responses . Positive_regulation EPHB2 CD79A 18481208 1840547 In contrast , induced *activation* of [ERK] , JNK , p38 , and Akt was not affected by ROS depletion . Positive_regulation EPHB2 CD79A 18725396 1984987 We found that in CB B cells *activation* of extracellular signal regulated kinase ( [ERK] ) and p38 following ligation of CD40 but not of the was inefficient . Positive_regulation EPHB2 CD79A 19218240 2054348 We have identified a 10-amino acid Ras binding domain within BLNK that is necessary for restoration of mediated [ERK] *activation* in BLNK-deficient B cells and for anti-apoptotic signaling . Positive_regulation EPHB2 CD79A 22951891 2701737 In human mesangial cells in vitro , [ERK] *activation* through mesangial receptor ( CD71 ) controlled pro-inflammatory cytokine secretion and was induced by large-molecular-mass IgA1 containing circulating immune complexes purified from patient sera . Positive_regulation EPHB2 CD79A 22951891 2701738 Moreover , dependent [ERK] *activation* required renin-angiotensin system as its blockade was efficient in reducing proteinuria in those patients exhibiting substantial mesangial activation of ERK . Positive_regulation EPHB2 CD79A 23325840 2758314 This results in the reduction of HS1 activation along with that of cytoskeletal effector VAV1 and the downstream kinase [ERK] also in the *presence* of and CXC chemokine receptor CXCR4 stimulation . Positive_regulation EPHB2 CD79A 24989471 2948147 Here , we indicate that the ZIP9 induces increase in intracellular zinc level and plays an important role in the phosphorylation of Akt and [Erk] in *response* to activation . Positive_regulation EPHB2 CD79A 9763608 537168 Here we demonstrate that the induced [ERK] *activation* is reduced by loss of Grb2 or expression of a dominant negative form of Ras , RasN17 , whereas this response is not affected by loss of Shc . Positive_regulation EPHB2 CD79B 10438726 635005 Because extracellular signal regulated kinases ( ERKs ) couple upstream signaling pathways to gene activation and are activated by B-cell antigen receptor (BCR) signaling , we examined whether CD22 ligation also activated ERKs and/or modified *induced* [ERK] activation . Positive_regulation EPHB2 CD79B 11726515 884444 In vivo expression of a Grb2 mutant where Tyr209 was changed to phenylalanine enhanced *induced* [ERK] activation and fibroblast transformation , and potentiated and prolonged Grb2 mediated activation of Ras , mitogen activated protein kinase and c-Jun N-terminal kinase in response to EGF stimulation . Positive_regulation EPHB2 CD79B 11823472 922654 We report that inhibition of mitogen activated protein kinase/extracellular signal regulated kinase kinase ( MEK)-1/2 blocked *induced* activation of extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 CD79B 12095152 960712 In contrast , cross linking *resulted* in [ERK] activation , although the activation in quiescent cells was case dependent . Positive_regulation EPHB2 CD79B 12411479 1010824 Loss of Raf-1 has no effect on mediated [ERK] *activation* , whereas B-Raf-deficient DT40 cells display a reduced basal ERK activity as well as a shortened BCR mediated ERK activation . Positive_regulation EPHB2 CD79B 12411479 1010829 Our study shows that mediated [ERK] *activation* involves a cooperation of both B-Raf and Raf-1 , which are activated specifically in a temporally distinct manner . Positive_regulation EPHB2 CD79B 12444544 1017451 These data implicate the Src kinase family in Stat5 and [Erk] *activation* downstream of , and identify myeloid-specific Src kinases as potential drug targets in CML . Positive_regulation EPHB2 CD79B 12904304 1150328 Preventing Rap activation had no effect on induced *activation* of [ERK] . Positive_regulation EPHB2 CD79B 15569688 1368316 With respect to MAPK activation , HSH2 was not observed to alter the activation of [ERK] or p38 in *response* to ligation , but it does significantly potentiate JNK activation . Positive_regulation EPHB2 CD79B 15749869 1379671 B cell receptor (BCR) cross-talk : CD40 engagement enhances *induced* [ERK] activation . Positive_regulation EPHB2 CD79B 16585562 1544194 Intracellular calcium signaling and [ERK] activation in *response* to engagement were also proportionately decreased and delayed , respectively , with stepwise reduction of plcgamma2 dosage in a BLNK ( null ) background . Positive_regulation EPHB2 CD79B 17522256 1751329 Coligation of this fusion protein with the B cell receptor (BCR) inhibited mediated calcium mobilization , intracellular tyrosine phosphorylation , and [Erk] kinase *activation* . Positive_regulation EPHB2 CD79B 17640867 1787655 The overexpression of LPXN in mouse A20 B lymphoma cells led to the suppression of *induced* activation of JNK , p38 MAPK , and , to a lesser extent , Akt , but not [ERK] and NFkappaB , suggesting that LPXN can selectively repress BCR signaling . Positive_regulation EPHB2 CD79B 17656488 1793748 Using Western blotting and phospho-specific flow cytometry , we now show that the kinetics and magnitude of mediated *activation* of [ERK-MAPK] are markedly attenuated in WEHI-231 cells and splenic B cells that have been exposed to low and nontoxic burdens of Hg ( +2 ) . Positive_regulation EPHB2 CD79B 17724683 1801603 *mediated* phosphorylation of Akt and [Erk] is sensitive to the PI3K catalytic inhibitor wortmannin in both marginal zone ( MZ ) and follicular ( FO ) cells . Positive_regulation EPHB2 CD79B 18448454 1921240 It was previously shown that Bam32-deficient mice have defects in various aspects of B cell activation including induced [Erk] *activation* , BCR induced proliferation and T-independent antibody responses . Positive_regulation EPHB2 CD79B 18481208 1840548 In contrast , *induced* activation of [ERK] , JNK , p38 , and Akt was not affected by ROS depletion . Positive_regulation EPHB2 CD79B 18725396 1984988 We found that in CB B cells *activation* of extracellular signal regulated kinase ( [ERK] ) and p38 following ligation of CD40 but not of the was inefficient . Positive_regulation EPHB2 CD79B 19218240 2054349 We have identified a 10-amino acid Ras binding domain within BLNK that is necessary for restoration of mediated [ERK] *activation* in BLNK-deficient B cells and for anti-apoptotic signaling . Positive_regulation EPHB2 CD79B 23325840 2758315 This results in the reduction of HS1 activation along with that of cytoskeletal effector VAV1 and the downstream kinase [ERK] also in the *presence* of and CXC chemokine receptor CXCR4 stimulation . Positive_regulation EPHB2 CD79B 24989471 2948148 Here , we indicate that the ZIP9 induces increase in intracellular zinc level and plays an important role in the phosphorylation of Akt and [Erk] in *response* to activation . Positive_regulation EPHB2 CD79B 9763608 537169 Here we demonstrate that the *induced* [ERK] activation is reduced by loss of Grb2 or expression of a dominant negative form of Ras , RasN17 , whereas this response is not affected by loss of Shc . Positive_regulation EPHB2 CD81 14676841 1211198 A mutant in the PTB domain of Shc failed to interact with phosphoinositides and localize to the plasma membrane thus blocking *induced* [ERK/MAPKinase] activation . Positive_regulation EPHB2 CD81 14676841 1211200 Therefore , we conclude that stimulates synthesis of phosphoinositides with the recruitment of Shc to the plasma membrane via PTB domain , and this sequence of events *induces* activation of [ERK/MAPKinase] . Positive_regulation EPHB2 CD81 16552713 1542093 engagement by monoclonal antibody or HCV-E2 *enhances* zeta and [Erk] phosphorylation in T cells and reduces them in NK cells , reflecting the opposite functional outcomes . Positive_regulation EPHB2 CD8A 16872849 1600697 A delayed and perhaps longer lasting interaction *results* in delayed [phospho-ERK] recruitment to the synapse . Positive_regulation EPHB2 CD8A 20595932 2303430 These results suggest that the interaction between on veto CTL and the MHC class I alpha3 domain on the effector cell , *leads* to phosphorylation of [MEK/ERK] in the latter cell , associated with a significant reduction of XIAP levels which , in turn , enables potent triggering of Fas-FasL mediated apoptosis on cognate binding of the veto CTLs . Positive_regulation EPHB2 CD8B 16872849 1600698 A delayed and perhaps longer lasting interaction *results* in delayed [phospho-ERK] recruitment to the synapse . Positive_regulation EPHB2 CD8B 20595932 2303431 These results suggest that the interaction between on veto CTL and the MHC class I alpha3 domain on the effector cell , *leads* to phosphorylation of [MEK/ERK] in the latter cell , associated with a significant reduction of XIAP levels which , in turn , enables potent triggering of Fas-FasL mediated apoptosis on cognate binding of the veto CTLs . Positive_regulation EPHB2 CD9 21161334 2402042 Phosphorylation of p38 but not ERK was *increased* by overexpression , total p38 and [ERK] were not affected . Positive_regulation EPHB2 CD97 22797060 2785912 Expression of transgenic in thyroid epithelium *led* to elevated [ERK] phosphorylation and increased numbers of Ki67+ cells in developing tumors . Positive_regulation EPHB2 CDC25A 15672448 1409536 and ERK interaction : EGFR independent [ERK] *activation* by a protein phosphatase Cdc25A inhibitor , compound 5 . Positive_regulation EPHB2 CDC42 12511425 1070793 We conclude from these data that *dependent* activation of [MAPK/ERK] is a critical event in the immediate phagocytic response of PMNs to microbial challenge . Positive_regulation EPHB2 CDC73 11934880 953469 In contrast , these inhibitors almost completely blocked both *induced* [ERK] phosphorylation and LTC ( 4 ) generation in PAFR cells . Positive_regulation EPHB2 CDC73 11934880 953474 However , in mPAFR cells pertussis toxin only partially inhibited *induced* [ERK] phosphorylation . Positive_regulation EPHB2 CDC73 11934880 953479 A Ca ( 2+ ) /calmodulin inhibitor had no effect on *induced* [ERK] phosphorylation in PAFR cells but completely blocked the response in mPAFR cells . Positive_regulation EPHB2 CDC73 12687020 1078712 *activated* three prominent mitogen activated protein kinase modules ( [ERK] , p38MAPK and Jun N-terminal kinases ) in these cells , inhibited proliferation and induced differentiation ( measured by the induction of Waf1/p21 and the induction of the differentiation related marker CEA ) . Positive_regulation EPHB2 CDC73 15115659 1241550 These results indicate that induced *activation* of [ERK] contributes to both the expression of the pro-adhesive phenotype and repression of neutrophil apoptosis , thereby amplifying the inflammatory response . Positive_regulation EPHB2 CDC73 15917990 1413200 *induced* [ERK] phosphorylation is mediated by PI3K , PKC , PLA2 , PLC , and extracellular calcium , whereas fMLP induced ERK phosphorylation does not involve the PKC-gamma isoform and extracellular calcium . Positive_regulation EPHB2 CDC73 20074623 2218622 These results suggest that *induces* synaptic facilitation through activation of CaMKII , PKC and [ERK] in the hippocampal CA1 region . Positive_regulation EPHB2 CDC73 23911909 2840514 Likewise , ERK phosphorylation was markedly enhanced in PAF stimulated VSMCs , and this was attenuated by WEB2086 , but not by EGF receptor inhibitor , demonstrating the specificity of PAF receptor (PAFR) in *induced* [ERK] phosphorylation . Positive_regulation EPHB2 CDC73 23911909 2840520 In addition , *induced* [ERK] phosphorylation and MMP-2 production were significantly attenuated by ß-arrestin2 depletion . Positive_regulation EPHB2 CDC73 9878562 557849 Stimulation of receptor *induces* activation of extracellular signal regulated kinase ( [ERK] ) and cytosolic phospholipase A2 (cPLA2) and release of arachidonic acid in Chinese hamster ovary cells . Positive_regulation EPHB2 CDC73 9915820 587188 The *induced* p38 and [ERK] pathways appeared to be preferentially regulated by RGS16 and RGS1 , respectively . Positive_regulation EPHB2 CDH2 10356298 618383 We have found that , as well as laminin ( LN ) and basic fibroblast growth factor (bFGF) , can *activate* [ERK] in embryonic chick retinal neurons . Positive_regulation EPHB2 CDH2 14561752 1175711 GnT-V overexpression resulted in decreased N-cadherin clustering on the cell surface induced by anti-N-cadherin antibody and affected the outside-in signal transduction pathway of [ERK] *mediated* by . Positive_regulation EPHB2 CDH2 17785185 1790521 *regulates* cytoskeletally associated [IQGAP1/ERK] signaling and memory formation . Positive_regulation EPHB2 CDH2 20647774 2304858 Here we show that Abl is necessary for p38alpha/beta activation initiated by N-cadherin ligation , but in contrast to Cdo , Abl is also required for *dependent* [ERK] activation . Positive_regulation EPHB2 CDK1 17463001 1750050 Immunoblotting demonstrated that phosphorylation at this site was maximal in cells in G2/M phase , was enhanced by tumor necrosis factor-alpha related apoptosis inducing ligand ( TRAIL ) treatment , was blocked by inhibitors of CDK ( but not [ERK] or glycogen-synthase kinase 3beta ) , and was *stimulated* in vitro by , CDK2 , and JNK1 . Positive_regulation EPHB2 CDK1 20664969 2298220 Immunoblot analysis demonstrated that oridonin treatment increased expression levels of p-JNK , p-p38 , p-p53 and p21 , elevated the level of cyclin ( Tyr15 ) complex , and *inhibited* the expression of [p-ERK] . Positive_regulation EPHB2 CDK2 17495535 1744424 In addition , Inhibition of PI3K , p38/HOG1 , Raf , and could not *block* the MNNG induced [p-Erk] activation , whereas U0126 and PD98059 abolished it . Positive_regulation EPHB2 CDK5 16273078 1566896 Inhibition of *inhibits* PI3K/Akt and [ERK] phosphorylation and Bcl-2 expression , and thus sensitizes the differentiated cells to DNA-damage . Positive_regulation EPHB2 CDK5 19531642 2109630 This study investigated whether *dependent* [ERK] activation underlies the estrogen elicited facilitation on the repetitive stimulation induced spinal reflex potentiaton (SRP) that is presumed to be involved in postinflammatory/neuropathic hyperalgesia and allodynia . Positive_regulation EPHB2 CDK5R1 22833568 2670908 The inhibition of activity *results* in enhanced [MEK-ERK] signaling , leading to CRNA . Positive_regulation EPHB2 CDKN1A 10781803 687946 This implies that a link exists between [ERK] activation and ( WAF ) and p27 ( kip1 ) *induction* in the process of terminal differentiation . Positive_regulation EPHB2 CDKN1A 12370305 995749 We demonstrated that in PMA induced adherent cells , upregulation of ( Cip1/Waf1 ) *requires* the activation and nuclear translocation of phosphorylated extracellular signal regulated kinase ( [phospho-ERK] ) . Positive_regulation EPHB2 CDKN1A 12370305 995755 Finally , we demonstrated that inhibition of ROCK restores nuclear distribution of [phospho-ERK] and *activation* of ( Cip1/Waf1 ) expression . Positive_regulation EPHB2 CDKN1A 12816758 1157191 Moreover , this [ERK] activation and cyclin D1 and ( Cip/WAF1 ) *induction* were abolished by PD-98059 pretreatment . Positive_regulation EPHB2 CDKN1A 12816758 1157198 The differential regulations of cell growth , [ERK] activities , and cyclin D1 and ( Cip/WAF1 ) *inductions* were also observed in serum enriched medium containing higher zinc concentrations . Positive_regulation EPHB2 CDKN1A 14679005 1179055 Enforced expression of doxycycline-inducible p21 ( CIP1 ) or constitutively active MEK1 significantly diminished 17-AAG/SAHA mediated lethality , indicating that interference with [ERK] activation and ( CIP1 ) *induction* play important functional roles in the lethal effects of this regimen . Positive_regulation EPHB2 CDKN1A 16806947 1599840 The antiproliferative effect was correlated with [ERK] activation and ( waf1 ) *induction* . Positive_regulation EPHB2 CDKN1A 19880762 2156867 Since PNC-2 blocks oncogenic *induced* activation of JNK and [ERK] , we further determined whether this peptide blocks activation of these kinases in NE-treated myocytes . Positive_regulation EPHB2 CDKN1A 20526801 2320123 [ERK] *activation* of is critical for medulloblastoma cell migration . Positive_regulation EPHB2 CDKN1A 23772367 2714502 VN attenuated radiation induced expression of p21 , an inhibitor of cell cycle progression , and selectively inhibited [Erk-] and p38 MAPK dependent *induction* after radiation exposure through regulation of the activity of GSK-3ß . Positive_regulation EPHB2 CDKN1A 24823378 2937663 Here , we show that the protein kinase [Erk] , which plays a central role in a number of key developmental processes in vertebrates , is *regulated* in the developing neural crest by . Positive_regulation EPHB2 CFL1 19553453 2099469 While constitutively active nonphosphorylatable cofilin ( S3A ) induced an immature spine profile , phosphomimetic ( S3D ) *restored* mature spine morphology in neurons with disrupted [EphB] activity or lacking FAK . Positive_regulation EPHB2 CFL2 19553453 2099470 While constitutively active nonphosphorylatable cofilin ( S3A ) induced an immature spine profile , phosphomimetic ( S3D ) *restored* mature spine morphology in neurons with disrupted [EphB] activity or lacking FAK . Positive_regulation EPHB2 CFLAR 16129431 1461140 This conclusion is based on the following observations : ( I ) Overexpression of FADD , caspase-8 , or a protein containing the death effector domains only *leads* to enhanced and prolonged [ERK] activation after TNF treatment . Positive_regulation EPHB2 CHGA 17267111 1697007 therefore , Src mediates *induced* [ERK] phosphorylation leading to iNOS expression and NO production . Positive_regulation EPHB2 CHI3L1 21357475 2426478 mAY also abolished induced *activation* of the membrane receptor VEGF receptor 2 ( Flk-1/KDR ) and intracellular signaling mitogen activated protein (MAP) kinase extracellular signal regulated kinase ( [Erk] ) 1 and Erk 2 . Positive_regulation EPHB2 CHUK 12600818 1085056 Ras was required for maximal activation of extracellular signal regulated kinase ( [ERK] ) and Jun amino terminal kinase (JNK) as well as AP-1 and NF-kappaB transcriptional activities , but not for *activation* of , an upstream activator of NF-kappaB . Positive_regulation EPHB2 CKS1B 20930946 2357109 Over-expression of *activates* both [MEK/ERK] and JAK/STAT3 signaling pathways and promotes myeloma cell drug-resistance . Positive_regulation EPHB2 CLDN1 23766441 2915876 An upregulated expression *induces* MMP-9 and [p-ERK] signalling to activate Notch signalling , which in turn inhibits the goblet cell differentiation . Positive_regulation EPHB2 CLN6 19211919 2061567 Exogenous angiotensin II induced IL-6 expression , *activation* of [extracellular regulated kinase (ERK)] 1/2 , and superoxide generation in pancreatic acinar cell line AR42J , which were reversed by the angiotensin II type 1 ( AT(1) ) receptor antagonist , losartan ( 2-butyl-4-chloro-1- [ p- ( o-1H-tetrazol-5-ylphenyl ) benzyl ] imidazole-5-methanol monopotassium salt , C ( 22 ) H ( 23 ) ) . Positive_regulation EPHB2 CLU 19218870 2039531 Exogenous *stimulates* Ras dependent Raf-1/mitogen activated protein kinase kinase ( MEK ) [/ERK] activation . Positive_regulation EPHB2 CMKLR1 22791765 2682082 Although dNK cells exhibit lower chemerin receptor ( CMKLR1 ) expression than their blood counterpart , engagement on dNK cells *resulted* in both [ERK] activation and migration through decidual ST cells . Positive_regulation EPHB2 CNKSR2 15028221 1222959 We show that the scaffold/adaptor protein is *required* for NGF- but not EGF induced [ERK] activation . Positive_regulation EPHB2 CNR1 12435806 1015957 However , the precise molecular mechanism for mediated [ERK] *activation* is still unknown . Positive_regulation EPHB2 CNR1 12435806 1015962 In conclusion , *induced* [ERK] activation was mediated by PI3K ( IB ) and this effect may have important consequences in the control of cell death/survival decision . Positive_regulation EPHB2 CNR1 14517212 1164972 A predominant role for inhibition of the adenylate cyclase/protein kinase A pathway in [ERK] *activation* by in N1E-115 neuroblastoma cells . Positive_regulation EPHB2 CNR1 14517212 1164980 These data implicate the inhibition of PKA as the predominant pathway for [ERK] *activation* by receptors in N1E-115 cells . Positive_regulation EPHB2 CNR1 15886210 1433047 Using CB1/2-/- murine embryonic fibroblasts , we present the first direct evidence that both are *involved* in 2-AG induced [ERK] activation . Positive_regulation EPHB2 CNR1 16864584 1613463 stimulation with HU210 *activated* [ERK] and induced the transcription factor Krox-24 . Positive_regulation EPHB2 CNR1 21074588 2371417 *induces* a biphasic [ERK] activation via multiprotein signaling complex formation of proximal kinases PKCe , Src , and Fyn in primary neurons . Positive_regulation EPHB2 CNR1 21518335 2567451 Phase I ( 0-5 min ) maximal [ERK] phosphorylation is *mediated* by receptor stimulated ligand independent transactivation of multiple receptor tyrosine kinases ( RTKs ) . Positive_regulation EPHB2 CNR1 21914493 2506742 *regulates* [ERK] and GSK-3ß dependent glucocorticoid inhibition of osteoblast differentiation in murine MC3T3-E1 cells . Positive_regulation EPHB2 CNR1 21914493 2506745 signaling *regulated* JNK , [ERK] , GSK-3ß , and Akt activation as well as Runx2 and IGF-I expression . Positive_regulation EPHB2 CNR2 15886210 1433044 Whether is *involved* in 2-AG induced [ERK] activation is still unclear . Positive_regulation EPHB2 CNTF 15525763 1329483 In contrast , *causes* preferential phosphorylation of [ERK] in progenitor cells and photoreceptor precursors . Positive_regulation EPHB2 CNTF 15525763 1329487 Inhibition of the cytokine receptor gp130 using neutralizing antibodies reveals that gp130 is required for both *induced* STAT3 and [ERK] phosphorylation . Positive_regulation EPHB2 CNTF 15855765 1353049 Perturbation of STAT and ERK signaling using protein kinase inhibitors and a dominant negative STAT3 mutant demonstrates that both *induced* STAT and [ERK] activation are involved in promoting Muller cell production . Positive_regulation EPHB2 COA1 23416149 2759877 *increased* [phospho-ERK] levels in a dose dependent manner and COA-Cl induced neuroprotection and ERK1/2 activation was inhibited by suramin or PD98059 . Positive_regulation EPHB2 COA3 23416149 2759879 *increased* [phospho-ERK] levels in a dose dependent manner and COA-Cl induced neuroprotection and ERK1/2 activation was inhibited by suramin or PD98059 . Positive_regulation EPHB2 COA4 23416149 2759878 *increased* [phospho-ERK] levels in a dose dependent manner and COA-Cl induced neuroprotection and ERK1/2 activation was inhibited by suramin or PD98059 . Positive_regulation EPHB2 COA5 23416149 2759880 *increased* [phospho-ERK] levels in a dose dependent manner and COA-Cl induced neuroprotection and ERK1/2 activation was inhibited by suramin or PD98059 . Positive_regulation EPHB2 COA6 23416149 2759876 *increased* [phospho-ERK] levels in a dose dependent manner and COA-Cl induced neuroprotection and ERK1/2 activation was inhibited by suramin or PD98059 . Positive_regulation EPHB2 COL1A1 19206162 2049866 Mechanical force *induces* expression in human periodontal ligament fibroblasts through activation of [ERK/JNK] and AP-1 . Positive_regulation EPHB2 COL1A2 19206162 2049867 Mechanical force *induces* expression in human periodontal ligament fibroblasts through activation of [ERK/JNK] and AP-1 . Positive_regulation EPHB2 COPS2 21403132 2421265 Here , we show that the 5 ( CSN5 ) is *required* for activation of proinflammatory kinases p38 and [Erk] and for down-regulation of the expression of genes regulated by nuclear factor E2-related factor 2 . Positive_regulation EPHB2 COPS3 21403132 2421262 Here , we show that the 5 ( CSN5 ) is *required* for activation of proinflammatory kinases p38 and [Erk] and for down-regulation of the expression of genes regulated by nuclear factor E2-related factor 2 . Positive_regulation EPHB2 COPS4 21403132 2421260 Here , we show that the 5 ( CSN5 ) is *required* for activation of proinflammatory kinases p38 and [Erk] and for down-regulation of the expression of genes regulated by nuclear factor E2-related factor 2 . Positive_regulation EPHB2 COPS5 21403132 2421263 Here , we show that the 5 ( CSN5 ) is *required* for activation of proinflammatory kinases p38 and [Erk] and for down-regulation of the expression of genes regulated by nuclear factor E2-related factor 2 . Positive_regulation EPHB2 COPS6 21403132 2421261 Here , we show that the 5 ( CSN5 ) is *required* for activation of proinflammatory kinases p38 and [Erk] and for down-regulation of the expression of genes regulated by nuclear factor E2-related factor 2 . Positive_regulation EPHB2 COPS8 21403132 2421264 Here , we show that the 5 ( CSN5 ) is *required* for activation of proinflammatory kinases p38 and [Erk] and for down-regulation of the expression of genes regulated by nuclear factor E2-related factor 2 . Positive_regulation EPHB2 CPD 10797308 689848 Both EGF and 5 *caused* an induction of [phospho-extracellular response kinase (ERK)] , which was also more sustained with Cpd 5 . Positive_regulation EPHB2 CPD 10797308 689850 Moreover , whereas 5 *induced* a striking translocation of phosphorylated [ERK] from cytosol to the nucleus , no significant nuclear translocation occurred after stimulation with EGF . Positive_regulation EPHB2 CPD 12115721 964300 Furthermore , 5 action *caused* a strong nuclear [phospho-ERK] signal and induced phospho-Elk-1 , a nuclear target of ERK activation , in contrast to the weak effects of EGF . Positive_regulation EPHB2 CPD 12115721 964302 The MEK inhibitors PD098056 and U0126 abrogated both the *induction* by 5 of [phospho-ERK] , its nuclear translocation and phospho-Elk-1 and also antagonized its growth inhibitory effects . Positive_regulation EPHB2 CPD 12540838 1071411 or 2- ( 2-mercaptoethanol ) -3-methyl-1,4-naphthoquinone , is an inhibitor of protein phosphatase Cdc25A and *causes* persistent activation of extracellular signal regulated kinase ( [ERK] ) and cell growth inhibition . Positive_regulation EPHB2 CPD 15319298 1341723 Inhibition of rat liver regeneration after partial hepatectomy and *induction* of [ERK] phosphorylation by 5 , a K vitamin based anticancer compound . Positive_regulation EPHB2 CPD 15672448 1409537 We now report that 5 can directly *cause* [ERK] phosphorylation by inhibiting Cdc25A activity independently of the EGFR pathway . Positive_regulation EPHB2 CPD 16596619 1550258 We previously showed that prolonged and strong [ERK] phosphorylation *induced* by , a Cdc25A protein phosphatase inhibitor , was involved in its mechanism of cell growth inhibition . Positive_regulation EPHB2 CPO 11083088 750443 We find that CP and *activate* extracellular signal regulated kinases ( [ERK] 44/42 ) in both wild-type ( CHOK1 ) and human muscarinic receptor expressing Chinese hamster ovary cells ( CHO-M2 ) . Positive_regulation EPHB2 CPO 11083088 750444 [ERK] 44/42 *activation* by is insensitive to the protein kinase A inhibitor H-89 , but is completely abolished by the phosphatidylinositol 3-kinase ( P13-K ) inhibitor wortmannin , the protein kinase C ( PKC ) inhibitor GF-109203X , and the mitogen activated extracellular signal regulated protein kinase kinase ( MEK ) inhibitor PD 098059 . Positive_regulation EPHB2 CPO 11781077 900133 This study tests the hypothesis that diacylglycerol ( DAG ) is the secondary messenger responsible for *induced* [ERK] 44/42 activation . Positive_regulation EPHB2 CPOX 14634122 1170905 Addition of exogenous PGE ( 1 ) or PGE ( 2 ) inhibited MMP-1 , reversed the effects of inhibitors , and *inhibited* [ERK] activation , suggesting that COX-2 activity tonically inhibits MMP-1 production via ERK inhibition by E PGs . Positive_regulation EPHB2 CPOX 19201774 2149171 All inhibitors *attenuated* [ERK] activation , but only celecoxib significantly inhibited Akt activation in HSCs . Positive_regulation EPHB2 CPT2 16912161 1601777 We also showed Rap1 and [ERK] *activation* by both hepatocyte growth factor (HGF) and <8CPT-2Me-cAMP> ( an activator of Epac , a Rap1 guanine nucleotide exchange factor ) in two human melanoma cell lines . Positive_regulation EPHB2 CPT2 22173489 2518307 Pretreatment of HUVECs with an ERK inhibitor PD98059 or a PI3K inhibitor LY294002 prior to stimulation not only blocked <8CPT-2'OMe-cAMP> *induced* phosphorylation of [ERK] and Akt , but also significantly reduced cell proliferation and migration . Positive_regulation EPHB2 CREB1 11371570 834854 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and [ERK] and *activation* of ( CREB ) , NF-kappaB , and E2F ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation EPHB2 CREB1 12008033 940711 We compared the BCR *induced* intracellular [ Ca2+ ] transient , protein tyrosine phosphorylation and [ERK] phosphorylation , furthermore , the activation of Elk-1 and transcription factors . Positive_regulation EPHB2 CREB1 16151051 1499400 In this study , we tested the hypotheses that oxidants induce Ca2+ mediated phosphorylation of [ERK] and CREB , and that is *required* for oxidant induced proliferation and apoptosis . Positive_regulation EPHB2 CREB1 16902997 1614672 Western blotting analysis showed that the protein level of phosphorylated [ERK] ( p-ERK ) in ipsilateral spinal dorsal horn was transiently increased after LTP induction , starting at 15 min and returning to control at 60 min after tetanic stimulation and that the protein level of *increased* at 30 min , persisting for at least 3 hr after LTP induction . Positive_regulation EPHB2 CREB1 17524392 1772967 ATP signaling through ERK and activated LMO4 promoters and [ERK] *activation* increased LMO4 protein stability in F11 cells . Positive_regulation EPHB2 CREB1 19385062 2069352 The exchange protein directly activated by cAMP ( Epac ) activator , 8CPT-2Me-cAMP , promoted the Akt/eNOS/NO pathway and [ERK] phosphorylation , but did not *induce* phosphorylation and VEGF expression . Positive_regulation EPHB2 CREB1 19508427 2108610 The sustained activation of [ERK] but a transient *activation* of together suggest that exposure to homocysteine initiates a feedback loop that shuts off CREB signaling without affecting ERK phosphorylation and thereby facilitates homocysteine mediated neurotoxicity . Positive_regulation EPHB2 CREB1 22915995 2657530 Specifically , PS and VS *induced* [ERK] phosphorylation , though they had no effect on phosphorylation of the cAMP response element binding protein ( ) . Positive_regulation EPHB2 CREB1 9808472 545238 Furthermore , the full expression of the late phase of long-term potentiation ( L-LTP ) and L-LTP associated CRE mediated transcription requires ERK activation , suggesting that the *activation* of by [ERK] plays a critical role in the formation of long lasting neuronal plasticity . Positive_regulation EPHB2 CREB3 11371570 834855 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and [ERK] and *activation* of ( CREB ) , NF-kappaB , and E2F ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation EPHB2 CREB3 12008033 940712 We compared the BCR *induced* intracellular [ Ca2+ ] transient , protein tyrosine phosphorylation and [ERK] phosphorylation , furthermore , the activation of Elk-1 and transcription factors . Positive_regulation EPHB2 CREB3 16151051 1499401 In this study , we tested the hypotheses that oxidants induce Ca2+ mediated phosphorylation of [ERK] and CREB , and that is *required* for oxidant induced proliferation and apoptosis . Positive_regulation EPHB2 CREB3 16902997 1614673 Western blotting analysis showed that the protein level of phosphorylated [ERK] ( p-ERK ) in ipsilateral spinal dorsal horn was transiently increased after LTP induction , starting at 15 min and returning to control at 60 min after tetanic stimulation and that the protein level of *increased* at 30 min , persisting for at least 3 hr after LTP induction . Positive_regulation EPHB2 CREB3 17524392 1772968 ATP signaling through ERK and activated LMO4 promoters and [ERK] *activation* increased LMO4 protein stability in F11 cells . Positive_regulation EPHB2 CREB3 19385062 2069353 The exchange protein directly activated by cAMP ( Epac ) activator , 8CPT-2Me-cAMP , promoted the Akt/eNOS/NO pathway and [ERK] phosphorylation , but did not *induce* phosphorylation and VEGF expression . Positive_regulation EPHB2 CREB3 19508427 2108611 The sustained activation of [ERK] but a transient *activation* of together suggest that exposure to homocysteine initiates a feedback loop that shuts off CREB signaling without affecting ERK phosphorylation and thereby facilitates homocysteine mediated neurotoxicity . Positive_regulation EPHB2 CREB3 22915995 2657531 Specifically , PS and VS *induced* [ERK] phosphorylation , though they had no effect on phosphorylation of the cAMP response element binding protein ( ) . Positive_regulation EPHB2 CREB3 9808472 545239 Furthermore , the full expression of the late phase of long-term potentiation ( L-LTP ) and L-LTP associated CRE mediated transcription requires ERK activation , suggesting that the *activation* of by [ERK] plays a critical role in the formation of long lasting neuronal plasticity . Positive_regulation EPHB2 CREB5 11371570 834853 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and [ERK] and *activation* of ( CREB ) , NF-kappaB , and E2F ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation EPHB2 CREB5 12008033 940710 We compared the BCR *induced* intracellular [ Ca2+ ] transient , protein tyrosine phosphorylation and [ERK] phosphorylation , furthermore , the activation of Elk-1 and transcription factors . Positive_regulation EPHB2 CREB5 16151051 1499399 In this study , we tested the hypotheses that oxidants induce Ca2+ mediated phosphorylation of [ERK] and CREB , and that is *required* for oxidant induced proliferation and apoptosis . Positive_regulation EPHB2 CREB5 16902997 1614671 Western blotting analysis showed that the protein level of phosphorylated [ERK] ( p-ERK ) in ipsilateral spinal dorsal horn was transiently increased after LTP induction , starting at 15 min and returning to control at 60 min after tetanic stimulation and that the protein level of *increased* at 30 min , persisting for at least 3 hr after LTP induction . Positive_regulation EPHB2 CREB5 17524392 1772966 ATP signaling through ERK and activated LMO4 promoters and [ERK] *activation* increased LMO4 protein stability in F11 cells . Positive_regulation EPHB2 CREB5 19385062 2069351 The exchange protein directly activated by cAMP ( Epac ) activator , 8CPT-2Me-cAMP , promoted the Akt/eNOS/NO pathway and [ERK] phosphorylation , but did not *induce* phosphorylation and VEGF expression . Positive_regulation EPHB2 CREB5 19508427 2108609 The sustained activation of [ERK] but a transient *activation* of together suggest that exposure to homocysteine initiates a feedback loop that shuts off CREB signaling without affecting ERK phosphorylation and thereby facilitates homocysteine mediated neurotoxicity . Positive_regulation EPHB2 CREB5 22915995 2657529 Specifically , PS and VS *induced* [ERK] phosphorylation , though they had no effect on phosphorylation of the cAMP response element binding protein ( ) . Positive_regulation EPHB2 CREB5 9808472 545237 Furthermore , the full expression of the late phase of long-term potentiation ( L-LTP ) and L-LTP associated CRE mediated transcription requires ERK activation , suggesting that the *activation* of by [ERK] plays a critical role in the formation of long lasting neuronal plasticity . Positive_regulation EPHB2 CREG1 24018888 2837261 In addition , blocking vascular endothelial growth factor ( VEGF ) in CREG overexpressed HUVEC and supplementation of VEGF in CREG knocked-down HUVEC identified that the pro-proliferative effect of was partially *mediated* by VEGF induced [ERK/cyclin] E activation . Positive_regulation EPHB2 CRH 17027144 1674312 *increased* [ERK] phosphorylation in AtT-20 cells , whereas the UCNs decreased it in A7r5 cells . Positive_regulation EPHB2 CRH 19573542 2182732 *induced* [ERK] phosphorylation in AtT20 cells occurs via a cAMP dependent mechanism requiring EPAC2 . Positive_regulation EPHB2 CRH 19573542 2182733 *induced* [ERK] phosphorylation has been shown to be an important mechanism underlying expression of pro-opiomelanocortin , a key precursor molecule in the hypothalamic pituitary adrenal axis . Positive_regulation EPHB2 CRH 19573542 2182734 In AtT20 cells , CRF signalling has been investigated but the mechanism behind *induced* [ERK] activity is not fully understood . Positive_regulation EPHB2 CRH 19573542 2182735 Treatment with PKA inhibitors had a minor effect on *induced* [ERK] signalling while phosphorylation of CREB was completely abolished . Positive_regulation EPHB2 CRH 19573542 2182736 Moreover , an activator of EPACs 8- ( 4-methoxyphenylthio ) -2'-O-methyladenosine-3',5'-cyclic monophosphate mimicked *induced* [ERK] phosphorylation . Positive_regulation EPHB2 CRH 19573542 2182737 The current study demonstrates a clear cAMP dependent but PKA independent mechanism underlying *induced* [ERK] activity that proceeds via EPAC2 signalling . Positive_regulation EPHB2 CRH 20056821 2211945 Because BMPs attenuated *induced* [ERK] and p38 phosphorylation , it was suggested that BMP-4 suppresses ACTH production by inhibiting CRH induced ERK and p38 phosphorylation . Positive_regulation EPHB2 CRH 21742013 2471830 Stimulation with CRH , but not GHRP-2 , activated ERK1/2 , p38 , SAPK/JNK and Akt phosphorylation , in which *induced* phosphorylation of [ERK] and p38 was suppressed by BMP-4 . Positive_regulation EPHB2 CRK 11546652 856541 Activation of was weak compared with that of JNK , and [ERK] was not *activated* at all . Positive_regulation EPHB2 CRK 12112010 963587 Thus , we speculate that during inflammatory conditions in vivo macrophage may *regulate* JNK and [ERK] activity and inhibit IL-10 expression . Positive_regulation EPHB2 CRK 12403788 1036157 SB203580 , a MAPK inhibitor , and PD98059 , an [ERK] *inhibitor* , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation EPHB2 CRK 15316932 1353589 The phosphorylation of [ERK] and JNK *induced* by overexpression of WT PKCalpha , and the phosphorylation of induced by WT PKCdelta , were regulated by Rho GTPases . Positive_regulation EPHB2 CRK 15467832 1305795 The expression level and activation of MEK1/2 or [ERK] showed no difference , but the kinase activity of apoptosis signal regulating kinase 1 ( ASK1 ) , JNK , or *increased* significantly compared with that in controls . Positive_regulation EPHB2 CRK 15833106 1403933 By means of specific inhibitors we showed that and ERK act downstream of CD28 and that [ERK] and JNK *act* downstream of ICOS leading to the induction of various T cell derived cytokines . Positive_regulation EPHB2 CRK 19033456 1998480 EKAR signals were correlated with ERK phosphorylation , *required* [ERK] activity , and did not report the activities of JNK or . Positive_regulation EPHB2 CRK 20814991 2341805 We further reveal that , in response to desiccation , human cells can rapidly initiate complex stress signaling networks involving all three MAPK pathways , with transient activation of [ERK] and sustained *activation* of JNK and . Positive_regulation EPHB2 CRK 24324260 2921452 In contrast , action of Met on ILDFb proliferation does not require [ERK] but does *require* ( MAPK ) . Positive_regulation EPHB2 CRK 8524249 335104 These results suggest that both and Grb2 may *contribute* to the activation of [Erk] by oncogenic Abl , whereas Nck is unlikely to participate in this pathway . Positive_regulation EPHB2 CRKL 11443118 850434 Overexpression of Lyn induced constitutive phosphorylation of and *activation* of [Erk] , whereas that of a Lyn mutant lacking the tyrosine kinase domain attenuated the Epo induced phosphorylation of CrkL and activation of Erk . Positive_regulation EPHB2 CRKL 16399079 1513033 is *required* for normal cellular responses to Fgf8 , including survival and migration , [Erk] activation , and target gene expression . Positive_regulation EPHB2 CROT 12821717 1104225 These findings indicate that is *essential* for LPS induced [ERK] activation and RANKL induction in osteoblasts . Positive_regulation EPHB2 CROT 15833743 1417998 signals *activate* [ERK] , JNK , and NF-kappaB in a cell-type and stimulus-specific manner . Positive_regulation EPHB2 CROT 21107320 2355370 *activates* [ERK] primarily through MEK dependent mechanisms that do not require RAF signalling . Positive_regulation EPHB2 CRP 24106269 2874785 *induced* phosphorylation of Syk , Akt , and [ERK] , but not SFK ( Src family kinase ) , was significantly reduced in RhoG-deficient platelets . Positive_regulation EPHB2 CSDE1 19304659 2073387 Mechanism of sustained *activation* of ribosomal S6 kinase ( RSK ) and [ERK] by kaposi sarcoma associated herpesvirus ORF45 : complexes retain active phosphorylated ERK AND RSK and protect them from dephosphorylation . Positive_regulation EPHB2 CSDE1 19319189 2052416 GTP-Raf-MEK-ERK to *promote* sustained [ERK] activation and regulate H-Ras dependent neuritogenesis . Positive_regulation EPHB2 CSE 19299917 2064148 In isolated rat AMs , *induced* MMP-9 expression and phosphorylation of [ERK] and Akt . Positive_regulation EPHB2 CSE 19299917 2064183 Simvastatin attenuated *mediated* activation of RAS and phosphorylation of [ERK] , Akt , p65 , IkappaB , and nuclear AP-1 or NF-kappaB activity . Positive_regulation EPHB2 CSE 24084092 2863446 Cigarette smoking extract also degraded the total amounts of Akt levels , and VEGF blunted *induced* phosphorylation of [Erk] . Positive_regulation EPHB2 CSE 24282280 2898686 Together , our results identify a signaling pathway involving PPAR-? , [ERK] , and MUC1 for TNF-a secretion *induced* by from macrophages . Positive_regulation EPHB2 CSE 24633465 2930391 In agreement with the *induced* activation of [ERK] , CSE induced reduction in viability , migration , and increase in both cytotoxicity and para-cellular permeability were observed in CSCs . Positive_regulation EPHB2 CSF1 10602507 574940 [ERK] *activation* by was robust and sustained in MCF-7fms and to a much lesser extent in T-47Dfms . Positive_regulation EPHB2 CSF1 12032835 948145 [ERK] activation was *increased* by doses capable to elicit a mitogenic response ( 2-5 U/ml ) . Positive_regulation EPHB2 CSF1 12444151 1017342 Because also *induces* activation of the mitogen activated protein (MAP) kinase [extracellular regulated kinase (Erk)] , we focused on dissecting the mechanism used by M-CSF to induce Erk activation in human monocytes . Positive_regulation EPHB2 CSF1 12444151 1017343 [Erk] *activation* by also seemed to play a role in cellular survival in monocytes . Positive_regulation EPHB2 CSF1 14579277 1156775 These isomerase inhibitors exerted a negative effect on a key element involved in macrophage proliferation , namely the *dependent* activation of the extracellular signal regulated kinases ( [ERK] ) . Positive_regulation EPHB2 CSF1 15013839 1220712 and RANKL *activate* the [ERK] , Akt , and NF-kappaB signal transduction pathways , and SCOH suppressed this activation . Positive_regulation EPHB2 CSF1 16357167 1492824 Constitutive activation of the extracellular signal regulated kinase ( ERK ) pathway also enhanced PDEF induced motility and invasion , suggesting that *activation* of the [ERK/mitogen] activated protein kinase by ErbB2 and can cooperate with PDEF to promote motility and invasion . Positive_regulation EPHB2 CSF1 16709817 1564303 However , whereas [ERK] phosphorylation in *response* to is Raf-1 dependent , in response to LPS , an alternative pathway directs the activation of these kinases . Positive_regulation EPHB2 CSF1 16931806 1673046 Macrophages from p47 ( phox-/- ) mice , lacking a key component of the NADPH oxidase complex required for ROS generation , had reduced cell survival and Akt1 and p38 mitogen activated protein kinase (MAPK) phosphorylation compared with wild-type macrophages in response to M-CSF stimulation , but had no difference in *stimulated* [Erk] . Positive_regulation EPHB2 CSF1 17443671 1749390 Under the proliferation inducing conditions ( TPA-free ) , parental or Nef-inactive cells showed modest [ERK] *activation* following stimulation , whereas Nef-active cells showed an earlier and transient ERK activation , despite a decrease in their proliferation rate . Positive_regulation EPHB2 CSF1 17443671 1749391 Under the differentiation inducing conditions , parental or Nef-inactive cells showed increased and prolonged [ERK] *activation* following stimulation , whereas Nef-active cells showed transient ERK activation . Positive_regulation EPHB2 CSF1 18275061 1924721 While M-CSF mediated MEK/ERK activation promotes osteoclast survival , the signaling pathway by which *activates* [MEK/ERK] is unresolved . Positive_regulation EPHB2 CSF1 18445346 1902726 Western blotting assay revealed that M-CSF activated ERK , JNK and p38 in both mature and immature macrophages , and cAMP inhibited *induced* [ERK] , JNK and p38 activation in a time dependent manner . Positive_regulation EPHB2 CSF1 18682602 1967714 Here we report that stimulation with IFN-gamma prolongs the pattern of [ERK] activity *induced* by in macrophages . Positive_regulation EPHB2 CSF1 19587381 2129553 In summary , *activates* [ERK] more potently than G-CSF , and thereby induces higher levels of c-Fos and phospho-C/EBPalpha ( S21 ) , which may directly interact to favor monopoiesis , whereas G-CSF activates signal transducer and activator of transcription 3 and SHP2 , potentially shifting the balance to granulopoiesis via gene induction by C/EBPalpha homodimers and via effects of SHP2 on regulators besides ERK . Positive_regulation EPHB2 CSF1 22028782 2499260 The role of atypical protein kinase C in *dependent* [Erk] activation and proliferation in myeloid progenitors and macrophages . Positive_regulation EPHB2 CSF1 22028782 2499261 PKC inhibitors and transfections with mutant PKCs showed that optimal *dependent* [Erk] activation and proliferation depended on the activity of PKC? . Positive_regulation EPHB2 CSF1 22073305 2504465 The ablated osteoclast formation in LIS1 depleted macrophages was associated with a significant decrease in macrophage proliferation , osteoclast survival and differentiation , which were caused by reduced *activation* of [ERK] and AKT by , prolonged RANKL induced JNK activation and declined expression of NFAT-c1 , a master transcription factor of osteoclast differentiation . Positive_regulation EPHB2 CSF1 9514945 493021 cAMP enhances *induced* [ERK] activity and c-fos mRNA expression via a MEK dependent and Ras independent mechanism in macrophages . Positive_regulation EPHB2 CSF1 9885215 584444 cAMP dramatically increased [ERK] activity in the *presence* of or IL-3 . Positive_regulation EPHB2 CSF1R 16098196 1443925 cAMP inhibits CSF-1 stimulated tyrosine phosphorylation but augments *mediated* macrophage differentiation and [ERK] activation . Positive_regulation EPHB2 CSF1R 16357167 1492825 Constitutive activation of the extracellular signal regulated kinase ( ERK ) pathway also enhanced PDEF induced motility and invasion , suggesting that *activation* of the [ERK/mitogen] activated protein kinase by ErbB2 and can cooperate with PDEF to promote motility and invasion . Positive_regulation EPHB2 CSF2 10378896 623896 In marked contrast to neutrophils and MO7e cells , did not *induce* tyrosine phosphorylation and activation of [ERK] in monocytes . Positive_regulation EPHB2 CSF2 10702314 672661 Granulocyte/macrophage , interleukin 3 , and TPA , all of which induced macrophage proliferation , also *induced* [ERK] activity , which was maximal at 5 min poststimulation . Positive_regulation EPHB2 CSF2 12063024 953295 Transient phosphorylation and activation of [ERK] was *induced* by both alone and combination of the two cytokines , whereas sustained phosphorylation and activation was induced only by the combination . Positive_regulation EPHB2 CSF2 15129224 1258686 However , the kinetics of ERK activation are different between rhGM-CSF and HQ in TF-1 cells : *results* in immediate activation of [ERK] , whereas HQ activation of ERK is delayed . Positive_regulation EPHB2 CSF2 15129224 1258688 Further , HQ and together produce an immediate *increase* in [ERK] phosphorylation , which is sustained for over 48 h. HQ also stimulates colony formation , AP-1 DNA binding and GM-CSF production in human CD34+ BM cells . Positive_regulation EPHB2 CSF2 16106368 1454192 Although IL-10 did not alter *activation* of [ERK] by or TNF-alpha , it did inhibit activation induced by LPS . Positive_regulation EPHB2 CSF2 16393981 1505989 For example , sodium salicylate blocked *stimulated* [Erk] and Akt activation , but resulted in rapid and sustained activation of p38-MAPK , an event mimicked by okadaic acid that also accelerates Mcl-1 turnover and neutrophil apoptosis . Positive_regulation EPHB2 CSF2 18091748 1847376 By contrast , *induced* phosphorylation of [ERK] , p38 , and Akt was affected by none of the blockers . Positive_regulation EPHB2 CSF2 19143758 2026071 TGFbeta inhibits *induced* phosphorylation of [ERK] and MEK in human myeloid leukaemia cell lines via inhibition of phosphatidylinositol 3-kinase (PI3-k) . Positive_regulation EPHB2 CSF2 19143758 2026085 PD98059 , a selective inhibitor of MEK , blocked *induced* phosphorylation of MEK and [ERK] but not p85 . Positive_regulation EPHB2 CSF2 19143758 2026093 These studies thus indicate that TGFbeta does not activate the ERK pathway but turns off the *induced* [ERK] signal via inhibition of the PI3-kinase-Akt pathway , in these human leukaemia cells . Positive_regulation EPHB2 CSF2 19179468 2061194 Ptpn11 ( D61Y ) common myeloid progenitors ( CMPs ) and granulocyte-monocyte progenitors (GMPs) produce cytokine independent colonies in a cell-autonomous manner and demonstrate elevated [Erk] and Stat5 activation in *response* to granulocyte-macrophage ( GM-CSF ) stimulation . Positive_regulation EPHB2 CSF2 19895919 2203453 In the context of osteoclastogenesis , macrophage ( M-CSF ) is an upstream *activator* of [ERK] signals for the survival of osteoclast precursors prior to their differentiation into multinucleated osteoclasts . Positive_regulation EPHB2 CSF2 20398804 2293949 [ERK] *activation* by reduces effectiveness of p38 inhibitor on inhibiting TNFalpha release . Positive_regulation EPHB2 CSF2 21506110 2418467 Requirement for PLC?2 in IL-3 and *stimulated* [MEK/ERK] phosphorylation in murine and human hematopoietic stem/progenitor cells . Positive_regulation EPHB2 CSF2 22028332 2574572 MD-Fraction *induced* production rapidly through Dectin-1 independent [ERK] and p38 MAPK activation . Positive_regulation EPHB2 CSF2 23620576 2795454 In vitro differentiation of JMML iPSCs produced myeloid cells with increased proliferative capacity , constitutive *activation* of granulocyte macrophage colony stimulating factor ( ) , and enhanced [STAT5/ERK] phosphorylation , similar to primary JMML cells from patients . Positive_regulation EPHB2 CSF2 9766635 538448 *stimulated* [ERK] activity comparable to that of TNF-alpha , but GM-CSF was a less potent stimulus of p38 MAPK activity . Positive_regulation EPHB2 CSF3 12954601 1185448 These findings suggest that TNF , GM-CSF , and *induce* actin depolymerization and morphological changes through activation of [ERK] and/or p38 MAPK and that cytokine induced actin reorganization may be partly responsible for the inhibitory effect of these cytokines on neutrophil chemotaxis . Positive_regulation EPHB2 CSF3 15671148 1366089 Stat3-null bone marrow cells displayed a significant activation of extra-cellular regulated kinase 1 (ERK1)/ERK2 under basal conditions , and the activation of [ERK] was *enhanced* and sustained by stimulation . Positive_regulation EPHB2 CSF3 16164983 1456402 Additionally , interleukin-3 , which inhibits G-CSF induced differentiation of 32 Dc l3 cells , also inhibited the ability of to *stimulate* prolonged [MEK/ERK] activation . Positive_regulation EPHB2 CSF3 16903868 1632693 These findings are consistent with the fact that selectively *activates* [MEK/ERK] and PI3K , but not p38 , in neutrophils . Positive_regulation EPHB2 CSF3 18358629 1898595 produced a significant *increase* in phospho-Akt and [phospho-ERK] in the motor neurons and exhibited beneficial effects on the spinal cord ischemia induced neurological defects . Positive_regulation EPHB2 CSF3 18764868 1980169 Inhibition of ROS or the [ERK] pathway remarkably decreased *induced* OLFM4 expression . Positive_regulation EPHB2 CSK 11681720 873913 Overexpression of that inactivates Src family tyrosine kinases also *inhibited* [ERK] activation evoked by GH . Positive_regulation EPHB2 CSK 15890337 1411495 In contrast , kinase-dead *augmented* the activation of FYN , RAS , and [ERK] and increased neurite outgrowth . Positive_regulation EPHB2 CSK 20497485 2339694 SP primed LTA and mediated *activation* of JNK , p38 and extracellular-signal regulated kinase ( [ERK] ) and activated the nuclear translocation of c-Jun , nuclear factor ( NF ) -?B , activating transcription factor 2 ( ATF-2 ) and cyclic-AMP-responsive element binding protein ( CREB ) transcription factors . Positive_regulation EPHB2 CSK 21042538 2344360 Pam ( 3 ) ( 4 ) and Tri-DAP strongly *enhanced* osteogenic differentiation and [ERK] phosphorylation in hUCB-MSCs , and LPS and MDP also slightly did . Positive_regulation EPHB2 CSK 21454454 2432649 Using Meg-01 cells and mouse megakaryocytes , we found that NF?B , [ERK-MAPK] , and PI3K/Akt pathways , known downstream pathways of TLRs , are *activated* by , a TLR2-specific ligand . Positive_regulation EPHB2 CSK 24205328 2864796 Furthermore , GW843682X inhibited induced *activation* of [ERK] and NF-?B , which contributed to Pam3CSK4 induced up-regulation of TNF-a . Positive_regulation EPHB2 CSK 9486662 488355 Overexpression of , which inactivates Src family tyrosine kinases , *suppressed* the activation of transfected [ERK] in cardiac fibroblasts . Positive_regulation EPHB2 CSPG4 15210734 1261960 Melanoma *enhances* FAK and [ERK] activation by distinct mechanisms . Positive_regulation EPHB2 CSPG5 15210734 1261961 Melanoma *enhances* FAK and [ERK] activation by distinct mechanisms . Positive_regulation EPHB2 CSRP1 12871378 1114087 There were no detectable perturbations in induced *activation* of Syk , PLCgamma2 , cortactin , [Erk] , Jnk , Akt or p38 in platelets from mice lacking Fps/Fes , Fer , or both kinases . Positive_regulation EPHB2 CSRP1 21679689 2451353 In addition , increased phosphorylation of p53 and [ERK] *induced* by was considerably reversed by Fc gamma receptor IIIa ( Fc?RIIIa ) knock-down using siRNA . Positive_regulation EPHB2 CSRP1 22142512 2536320 Our results showed that markedly *activated* [c-Raf/MEK/ERK] and JAK1/ERK signaling pathways but not JAK1/STAT3 signaling pathway by using the phosphor-specific antibodies against these pathways , and blockages of c-Raf/MEK/ERK and JAK1/ERK signaling pathways by the specific ERK1/2 inhibitor U0126 and JAK1 inhibitor piceatannol could significantly decrease CRP induced MMP-10 expression . Positive_regulation EPHB2 CTF1 19187601 2007152 did not *activate* extracellular signal regulated kinases ( [ERK] ) , c-Jun N-terminal kinase (JNK) and p38 . Positive_regulation EPHB2 CTGF 11732999 885271 In the proliferation phase , *induced* a approximately fivefold increase in the phosphorylation of p44/42 [MAPK/ERK] and a approximately twofold increase in that of p38 MAPK in an in vivo kinase assay . Positive_regulation EPHB2 CTGF 15371538 1334536 Using Ccn2-/- mouse embryonic fibroblasts , we show that loss of endogenous results in impaired spreading on fibronectin , delayed alpha-smooth muscle actin stress fiber formation , and *reduced* [ERK] and focal adhesion kinase phosphorylation . Positive_regulation EPHB2 CTGF 15855807 1425607 TGF-beta1 induced connective tissue growth factor ( ) expression in human renal proximal tubule epithelial cells *requires* [Ras/MEK/ERK] and Smad signalling . Positive_regulation EPHB2 CTGF 19276073 2072863 Additionally , in MMP-2-deficient cells did not *induce* the formation of stress fibers , focal adhesion sites , and [ERK] phosphorylation . Positive_regulation EPHB2 CTGF 20965247 2365231 Finally , we demonstrated that induction in response to LPA *requires* the activation of JNK , but not [ERK] , signaling pathways . Positive_regulation EPHB2 CTGF 23722620 2853919 *induces* osteogenic differentiation of vascular smooth muscle cells through [ERK] signaling . Positive_regulation EPHB2 CTNNB1 19270709 2055661 Finally , using human BMSCs as a test population , we show that substance P stimulates transmigration , cell proliferation , *activation* of the extracellular signal related kinases ( [Erk] ) 1 and 2 and nuclear translocation of in vitro . Positive_regulation EPHB2 CTNNBL1 12672049 1076328 Here , we show that *induces* [extracellular regulated kinase (ERK)] and p38-mitogen activated protein kinase (MAPK) activation in human neutrophils ; Positive_regulation EPHB2 CTNND1 23261059 2709253 The reduced intracellular cAMP levels to unstimulated levels and *activated* [ERK] phosphorylation within 30 min . Positive_regulation EPHB2 CTR9 11934880 953470 In contrast , these inhibitors almost completely blocked both *induced* [ERK] phosphorylation and LTC ( 4 ) generation in PAFR cells . Positive_regulation EPHB2 CTR9 11934880 953475 However , in mPAFR cells pertussis toxin only partially inhibited *induced* [ERK] phosphorylation . Positive_regulation EPHB2 CTR9 11934880 953480 A Ca ( 2+ ) /calmodulin inhibitor had no effect on *induced* [ERK] phosphorylation in PAFR cells but completely blocked the response in mPAFR cells . Positive_regulation EPHB2 CTR9 12687020 1078713 *activated* three prominent mitogen activated protein kinase modules ( [ERK] , p38MAPK and Jun N-terminal kinases ) in these cells , inhibited proliferation and induced differentiation ( measured by the induction of Waf1/p21 and the induction of the differentiation related marker CEA ) . Positive_regulation EPHB2 CTR9 15115659 1241551 These results indicate that induced *activation* of [ERK] contributes to both the expression of the pro-adhesive phenotype and repression of neutrophil apoptosis , thereby amplifying the inflammatory response . Positive_regulation EPHB2 CTR9 15917990 1413201 *induced* [ERK] phosphorylation is mediated by PI3K , PKC , PLA2 , PLC , and extracellular calcium , whereas fMLP induced ERK phosphorylation does not involve the PKC-gamma isoform and extracellular calcium . Positive_regulation EPHB2 CTR9 20074623 2218623 These results suggest that *induces* synaptic facilitation through activation of CaMKII , PKC and [ERK] in the hippocampal CA1 region . Positive_regulation EPHB2 CTR9 23911909 2840515 Likewise , ERK phosphorylation was markedly enhanced in PAF stimulated VSMCs , and this was attenuated by WEB2086 , but not by EGF receptor inhibitor , demonstrating the specificity of PAF receptor (PAFR) in *induced* [ERK] phosphorylation . Positive_regulation EPHB2 CTR9 23911909 2840521 In addition , *induced* [ERK] phosphorylation and MMP-2 production were significantly attenuated by ß-arrestin2 depletion . Positive_regulation EPHB2 CTR9 9878562 557850 Stimulation of receptor *induces* activation of extracellular signal regulated kinase ( [ERK] ) and cytosolic phospholipase A2 (cPLA2) and release of arachidonic acid in Chinese hamster ovary cells . Positive_regulation EPHB2 CTR9 9915820 587189 The *induced* p38 and [ERK] pathways appeared to be preferentially regulated by RGS16 and RGS1 , respectively . Positive_regulation EPHB2 CTSB 9390997 467670 Moreover , PD 98059 inhibited phorbol ester stimulation of production and *activation* of [ERK] in both human embryonic kidney cells and cortical neurons . Positive_regulation EPHB2 CTSG 12707281 1100389 This study provides the first evidence that promotes inositol 1,4,5-trisphosphate accumulation , *activates* [ERK] , p38 MAPK , and AKT , and decreases contractile function in cardiomyocytes . Positive_regulation EPHB2 CUL1 11412047 828333 *induced* a rapid and transient activation of [ERK] and p38 in a dose dependent manner . Positive_regulation EPHB2 CUL1 15465815 1342229 These data suggest that Spred-1 negatively regulates hematopoiesis by suppressing not only *induced* but also IL-3 induced [ERK] activation . Positive_regulation EPHB2 CUL1 19956885 2185004 LY294002 and PD98059 inhibited *induced* Akt and [Erk] activation in H209 cells , respectively . Positive_regulation EPHB2 CUL1 21330471 2415115 Half the population phosphorylated [Erk] in *response* to between 0.9 and 1.2 minutes , and S6 phosphorylation followed approximately a minute later ( t & frac12 ; ( pS6 rise ) = 2.2-2.7 minutes ) . Positive_regulation EPHB2 CX3CL1 17963723 1820272 The down-regulation of CX3CR1 mRNA correlated with the suppression of *induced* activation of Akt and [ERK] as well as chemotaxis . Positive_regulation EPHB2 CXADR 14645111 1210270 Taken together , our data show that *activation* of PI3K and p38 MAPK but not of [MEK1/ERK] by the promotes proliferation of H-500 cells as well as affords protection against apoptosis . Positive_regulation EPHB2 CXADR 16407414 1554042 Cotreatment with the Rho kinase inhibitors Y-27632 and H1152 attenuated the *induced* morphological change but not intracellular Ca2+ ( Ca2+ ( i ) ) mobilization or [ERK] activation , although transfection with a dominant negative RhoA binding protein also inhibited calcimimetic induced actin stress fiber assembly . Positive_regulation EPHB2 CXADR 16407414 1554043 In contrast , CaR induced cytoskeletal changes were not induced by the aromatic amino acids , treatments that also failed to potentiate *induced* [ERK] activation despite inducing Ca2+ ( i ) mobilization . Positive_regulation EPHB2 CXCL1 12549928 1051398 Moreover , CXCL10 can inhibit *induced* PAK1 and [ERK] activation as well as the CXCL1 induced chemotaxis through decreasing CXCL1 binding to cell surface heparan sulfate . Positive_regulation EPHB2 CXCL10 15613278 1357410 Further detailed analysis was performed on the NUB6 and SK-NMC neuroblastoma cells , showing that *induced* potent [Erk] phosphorylation in a G ( alpha ) i-dependent manner . Positive_regulation EPHB2 CXCL10 18291705 1924926 In cells expressing CXCR3-A , ( IP-10 ) at nanomolar concentrations *induced* activation of [ERK] , Akt , and Src , as previously described in human vascular pericytes . Positive_regulation EPHB2 CXCL10 23964117 2873328 The induction of *required* [ERK] , JNK , p38 MAPK , PKC , PTK , PI3K , and ROS . Positive_regulation EPHB2 CXCL11 15613278 1357412 The role of a CXCR3-like receptor in Erk phosphorylation was substantiated by the ability of , another potent CXCR3 ligand , to *induce* [Erk] phosphorylation in the NUB6 and SK-NMC cells . Positive_regulation EPHB2 CXCL12 11022134 738159 *induced* activation of [ERK] enhances HIV-1 expression . Positive_regulation EPHB2 CXCL12 12783869 1119870 *Activation* of [ERK] by the chemokine can be regulated by adhesion to beta 1-integrin substrates in the T-cell lines MOLT-3 , Jurkat , and H9 and in the Daudi B-cell line . Positive_regulation EPHB2 CXCL12 12817019 1103576 Because TCR activates ERK via SLP-76 mediated activation of the linker of activated T cells (LAT) scaffold protein , we examined the role of LAT in mediated [ERK] *activation* . Positive_regulation EPHB2 CXCL12 12817019 1103579 Together , our results describe the distinct mechanism by which *stimulates* prolonged [ERK] activation in T cells and indicate that this pathway is specific for cells expressing both ZAP-70 and SLP-76 . Positive_regulation EPHB2 CXCL12 15601627 1356696 Here we demonstrate that *activates* [Erk] synergistically with interleukin-3 (IL-3) in hematopoietic cells . Positive_regulation EPHB2 CXCL12 15601627 1356728 These results suggest that synergistically *enhances* IL-3 induced [Erk] activation by up-regulating Raf-1 activity through the Rac effector Pak kinases to promote hematopoiesis . Positive_regulation EPHB2 CXCL12 15611253 1357330 This was accompanied by diminished *induced* T cell adhesion and [ERK] phosphorylation . Positive_regulation EPHB2 CXCL12 15816868 1393317 Stimulation of the more differentiated progenitors ( E14.5 ) with *resulted* in rapid activation of the extracellular signal regulated kinase ( [ERK] ) 1/2 . Positive_regulation EPHB2 CXCL12 15816868 1393318 This *induced* [ERK] activity was dose dependent and could be inhibited by pre-treatment of the cells with either pertussis toxin , an inactivator of G-protein coupled receptors , or PD98059 , a MEK1 inhibitor . Positive_regulation EPHB2 CXCL12 16210428 1501061 A large portion of the *mediated* [ERK] phosphorylation was detected in the nucleus , as shown by Western blotting and confocal microscopy , and resulted in the phosphorylation of the transcription factor Elk . Positive_regulation EPHB2 CXCL12 16781119 1631598 However , inhibition of the Lyn kinase activity failed to affect induced *activation* of the small GTPases and [Erk] . Positive_regulation EPHB2 CXCL12 16919488 1602806 This pathway is responsible for several of the effects of SDF-1alpha on T cells , including prolonged [ERK] MAP kinase activity , increased intracellular calcium ion concentrations , robust AP-1 transcriptional activity , and *costimulation* of cytokine secretion . Positive_regulation EPHB2 CXCL12 17169599 1688021 These results suggest that OSM *induces* secretion of through [ERK-] , but not VEGF- , dependent signaling pathways in mesenchymal stem cells . Positive_regulation EPHB2 CXCL12 18839394 2012915 We show that stimulates the invasive migration of a TGCT cell line in vitro in a CXCR4 dependent fashion and *activates* [ERK] . Positive_regulation EPHB2 CXCL12 19155474 2027116 In addition , *augmented* the CCR7 ligand-driven [ERK] phosphorylation and actin polymerization in T cells under the same conditions . Positive_regulation EPHB2 CXCL12 19305148 2056190 CXCR4 was expressed and functional in both PD and LB cells , PD and LB cells migrated specifically toward the receptor ligand , CXCL12 and [P-Erk] was specifically *induced* by . Positive_regulation EPHB2 CXCL12 19609283 2142738 and PDGF *enhance* alphavbeta5 mediated [ERK] activation and adhesion independent growth of human pre-B cell lines . Positive_regulation EPHB2 CXCL12 21045835 2349284 *induced* the activation of FAK , [ERK] , and Akt signalling pathways , enhanced transcriptional activities of ß-catenin and NF-?B , and expression of survival proteins . Positive_regulation EPHB2 CXCL12 21079155 2376740 The *induced* phosphorylation of [ERK] and MEK in ZAP-70 ( + ) CLL cells was blocked by sorafenib , a small molecule inhibitor of RAF . Positive_regulation EPHB2 CXCL12 21771725 2484481 These data indicate that TXNIP negatively regulates bladder carcinogenesis by attenuating *induced* [ERK] activation . Positive_regulation EPHB2 CXCL12 21915267 2479441 Elucidation of the molecular mechanisms using various biochemical techniques and confocal microscopy revealed that JWH-015 treatment inhibited *induced* P44/P42 [ERK] activation , cytoskeletal focal adhesion and stress fiber formation , which play a critical role in breast cancer invasion and metastasis . Positive_regulation EPHB2 CXCL12 22083878 2540827 Likewise , pertussis toxin abolished *induced* activation of [Erk] and Akt in CXCR7-only expressing human glioma cell lines . Positive_regulation EPHB2 CXCL12 22932666 2678429 also *stimulates* the phosphorylation of intracellular signaling Akt and [Erk] , and their specific antagonists impede CXCL12 induced chemotaxis . Positive_regulation EPHB2 CXCL12 23251606 2708935 We found that WEV and WEV+NP clearly decreased the mediated *activation* of AKT , [ERK] , NF?B and Rho-A using western blot analysis ; Positive_regulation EPHB2 CXCL12 23784812 2849181 Glyceollin treatment suppressed activation of Akt , [Erk] , and eNOS *induced* by or vascular endothelial growth factor ( VEGF ) . Positive_regulation EPHB2 CXCL12 24876262 2940900 interaction *activated* AKT , extracellular signal regulated kinases ( [ERK] ) , and P38 mitogen activated protein kinase (MAPK) signaling pathways but not the c-Jun N-terminal kinase (JNK) pathway . Positive_regulation EPHB2 CXCL16 19438592 2078066 treatment *induced* HGF proliferation and phosphorylation of [extracellular regulated kinase (ERK)] and protein kinase B ( AKT ) in HGF . Positive_regulation EPHB2 CXCL16 19438592 2078068 In conclusion , HGF expressed CXCR6 functionally , because *induced* HGF proliferation and [ERK] and AKT phosphorylation in HGF . Positive_regulation EPHB2 CXCL5 20945384 2389414 Our study suggests that inhibition of *mediated* [ERK/Egr-1/Snail] signaling is an attractive therapeutic target for androgen independent prostate cancer . Positive_regulation EPHB2 CXCR3 11136732 795023 In MC , which respond to CXCR3 ligands with increased DNA synthesis , activation *resulted* in a biphasic stimulation of [ERK] activation , a pattern similar to the one observed in HSC exposed to platelet derived growth factor , indicating that this type of response is related to the stimulation of cell proliferation . Positive_regulation EPHB2 CXCR3 15613278 1357413 The *role* of a receptor in [Erk] phosphorylation was substantiated by the ability of CXCL11 , another potent CXCR3 ligand , to induce Erk phosphorylation in the NUB6 and SK-NMC cells . Positive_regulation EPHB2 CXCR4 12370187 1019613 Further analysis reveals that expression of beta-arrestin2 strengthened *mediated* activation of both p38 MAPK and [ERK] , and the suppression of beta-arrestin2 expression blocked the activation of two kinases . Positive_regulation EPHB2 CXCR4 18175225 1671214 We show that after CXCR4 activation , EGFR becomes tyrosine phosphorylated , and the kinase activity of this receptor , together with the activation of MMPs , Src , and PI3-Kinase , is required for mediated [ERK] *activation* . Positive_regulation EPHB2 CXCR4 18481208 1840575 The differential requirement for ROS in the *activation* of [ERK] , JNK , p38 , and Akt by the BCR , CD40 , and likely reflects the multiplicity of upstream activators for each of these kinases , only some of which may be regulated in a redox dependent manner . Positive_regulation EPHB2 CXCR4 20102637 2213036 Chondrosarcoma cell invasion is increased by hypoxia induced expression of and MMP1 and is *mediated* by HIF-1a and [ERK] . Positive_regulation EPHB2 CXCR4 21771725 2484482 These data indicate that TXNIP negatively regulates bladder carcinogenesis by attenuating induced [ERK] *activation* . Positive_regulation EPHB2 CXCR4 23251606 2708936 We found that WEV and WEV+NP clearly decreased the *mediated* activation of AKT , [ERK] , NF?B and Rho-A using western blot analysis ; Positive_regulation EPHB2 CXCR4 23308188 2725957 RasGRP1 , but not RasGRP3 , is required for efficient thymic ß-selection and [ERK] *activation* downstream of . Positive_regulation EPHB2 CXCR4 23308188 2725960 Also , we report that RasGRP1 is required for [ERK] *activation* downstream of signaling , which we hypothesize represents a potential mechanism of RasGRP1 regulation of ß-selection . Positive_regulation EPHB2 CXCR4 24876262 2940901 interaction *activated* AKT , extracellular signal regulated kinases ( [ERK] ) , and P38 mitogen activated protein kinase (MAPK) signaling pathways but not the c-Jun N-terminal kinase (JNK) pathway . Positive_regulation EPHB2 CYBB 17940286 1835537 Rac1 , therefore , bifurcates Tat signaling , leading to concurrent but separate Nox4 dependent [Ras/ERK] activation , and dependent JNK *activation* . Positive_regulation EPHB2 CYCS 16053510 1438682 These findings indicate that HIF-1alpha prevents apoptotic cell death through two mechanisms , including inhibition of release and *activation* of Akt and [ERK] . Positive_regulation EPHB2 CYR61 24593181 2942724 We propose the following model of Cyr61 neuroprotection within the retina : stimulates retinal Müller glial ( RMG ) and retinal pigment epithelium (RPE) cells and *activates* PI3K/Akt , mitogen activated protein kinase ( MAPK ) [/Erk] and Janus kinase ( JAK ) /Stat signalling pathways in these cells . Positive_regulation EPHB2 CYSLTR1 15041474 1224416 Finally , agonist induced stimulation was *followed* by a specific [extracellular regulated kinase (ERK)] 1/2 phosphorylation , an event with a pharmacological profile similar to that of Ras activation , partially ( approximately 40 % ) sensitive to Clostridium sordellii lethal toxin and totally blocked by PTx . Positive_regulation EPHB2 CYSLTR1 15041474 1224417 In conclusion , LTD ( 4 ) -induced receptor activation in dU937 cells *leads* to Ras activation and [ERK] phosphorylation mostly through a PTx-sensitive G ( i/o ) protein , PLC , and Ca ( 2+ ) -dependent tyrosine kinase ( s ) . Positive_regulation EPHB2 DAB1 15773914 1384600 Activation of apoE receptors also induced tyrosine phosphorylation of Dab1 , an adaptor protein of apoE receptors , but experiments in Dab1 knockout neurons demonstrated that was not *necessary* for [ERK] activation . Positive_regulation EPHB2 DAB2 17255372 1732929 Overexpression of in cardiac fibroblasts *led* to inhibition of hypertrophy agonist stimulated [ERK] activation and collagen expression . Positive_regulation EPHB2 DAG1 12802077 1101283 The [ERK] activation was *mediated* by integrin alpha6beta1 and not by alpha3beta1 or . Positive_regulation EPHB2 DAG1 23395731 2748338 Activation of extracellular signal related kinase ( [ERK] ) by OGD was *dependent* on binding , and inhibition of ERK activity with U0126 abrogated the loss of water uptake following OGD . Positive_regulation EPHB2 DAP 21042538 2344361 Pam ( 3 ) CSK ( 4 ) and strongly *enhanced* osteogenic differentiation and [ERK] phosphorylation in hUCB-MSCs , and LPS and MDP also slightly did . Positive_regulation EPHB2 DAPK1 15616583 1361985 Conversely , *promotes* the cytoplasmic retention of [ERK] , thereby inhibiting ERK signaling in the nucleus . Positive_regulation EPHB2 DAPK2 15616583 1361986 Conversely , *promotes* the cytoplasmic retention of [ERK] , thereby inhibiting ERK signaling in the nucleus . Positive_regulation EPHB2 DAPK3 15616583 1361987 Conversely , *promotes* the cytoplasmic retention of [ERK] , thereby inhibiting ERK signaling in the nucleus . Positive_regulation EPHB2 DAPP1 18448454 1921241 By comparing CD4 ( + ) T cells from lymph nodes of wild-type and Bam32-deficient mice , we found that was *required* for optimal TCR induced [Erk] activation , cytokine production , proliferation and actin mediated spreading of CD4 ( + ) T cells . Positive_regulation EPHB2 DAPP1 22981863 2688685 LAT independent [Erk] *activation* via complexes : GTPase independent Pak1 activation . Positive_regulation EPHB2 DCC 15811950 1392209 Moreover , this raft localization of DCC is required for netrin-1 induced *dependent* [ERK] activation , and netrin-1 mediated axon outgrowth requires lipid raft integrity . Positive_regulation EPHB2 DCD 19014393 2029104 Furthermore , we confirmed that could *induce* phosphorylation of p38 and [ERK] , and noticeably upregulated NF-kappaB activation . Positive_regulation EPHB2 DCT 14712208 1197011 Indeed , overexpression in a melanoma cell line *resulted* in increased [ERK] activity . Positive_regulation EPHB2 DDC 18215168 1870962 It has been recently reported that robust expression of the gene *requires* activation of extracellular signal regulated kinase ( [ERK] ) in epidermal cells of wounded Drosophila embryos . Positive_regulation EPHB2 DDR1 21344393 2480488 In addition , collagen I-bound *increased* GTP bound Ras , phosphoinositide 3-kinase (PI3K) p85a catalytic subunit protein expression , and Akt and [ERK] phosphorylation . Positive_regulation EPHB2 DDT 14604893 1200326 treatment *induces* phosphorylation of [ERK] and p38 , while JNK phosphorylation levels are slightly decreased . Positive_regulation EPHB2 DDT 20678559 2317251 o , also *increased* the phosphorylation of PKA , Akt , [ERK] , and JNK in their signaling pathways in MCF-7 and MDA-MB-231 cells . Positive_regulation EPHB2 DEDD 11965497 932797 are *involved* in important cellular processes such as death-receptor induced apoptosis , NF-kappaB activation and [ERK] activation . Positive_regulation EPHB2 DEFB4B 20190140 2229239 As evidenced by the inhibitory effects of MAPK-specific inhibitors , and LL-37 *activated* the phosphorylation of MAPKs p38 , [ERK] , and JNK that were required for IL-31 production and release . Positive_regulation EPHB2 DEFB4B 21367976 2431748 *induced* phosphorylation of JNK , [ERK] , and Akt in T cells . Positive_regulation EPHB2 DERL1 23306155 2746520 overexpression *up-regulated* MMP-2/9 expression and [ERK] phosphorylation , which could be reversed by MAP kinase/ERK kinase inhibitor , PD98059 . Positive_regulation EPHB2 DERL1 23306155 2746527 EGFR inhibitor blocked *mediated* up-regulation of EGFR and [ERK] phosphorylation . Positive_regulation EPHB2 DERL1 23306155 2746528 MMP-2/9 and [p-ERK] *up-regulation* by was partly blocked in EGFR depleted cells with siRNA treatment . Positive_regulation EPHB2 DHCR24 21486081 2428416 Hesperetin also stimulated the activation of Akt , [ERK] , and CREB as well as *induced* brain derived neurotrophic factor , PPAR? coactivator 1a ( PGC-1a ) , and ( selective Alzheimer 's disease indicator-1 ) via both ER and TrkA in the cells . Positive_regulation EPHB2 DISC1 17202467 1681072 These results suggest that is *required* for NT-3 induced axon elongation and [ERK] activation at the distal part of axons by recruiting Grb2 to axonal tips . Positive_regulation EPHB2 DLK1 17210639 1702594 We conclude that *activates* [MEK/ERK] signaling , which is required for Pref-1 inhibition of adipogenesis . Positive_regulation EPHB2 DLK1 20457810 2275640 We also show that fibronectin is required for the mediated inhibition of adipocyte differentiation , the *activation* of [ERK/MAPK] , and the upregulation of Sox9 . Positive_regulation EPHB2 DLK1 20457810 2275679 Pref-1 activates the integrin downstream signaling molecules , FAK and Rac , and [ERK] *activation* by is blunted by the knockdown of Rac or by the forced expression of dominant negative Rac . Positive_regulation EPHB2 DMP1 21401930 2404503 In Drosophila , , that encodes an ERK scaffold protein , *regulates* [ERK] signaling during wing development and contributes to intervein and vein cell differentiation . Positive_regulation EPHB2 DNAJB9 20008963 2217587 Further study revealed that both and S1P *induce* Akt and [ERK] phosphorylation in a dose- and time dependent manner , an effect that is attenuated by pre-treatment with either the Akt inhibitor wortmannin or the ERK inhibitor PD98059 , and MDG-1 can also induce eNOS phosphorylation and increases in production of NO . Positive_regulation EPHB2 DNLZ 11923291 947237 *stimulates* a transient increase in [ERK] activation , which is abrogated by both PTX and PI3K inhibitors . Positive_regulation EPHB2 DNLZ 15371459 1334533 does not *activate* [ERK] or PI 3-kinase in FAK knockout fibroblasts , suggesting activation occurs downstream of FAK . Positive_regulation EPHB2 DNM1 18442977 1921087 Inhibition of the signaling *blocked* 5-HT(2A/C) activation of [ERK] and the counteractive effect of 5-HT(2A/C) on 5-HT(1A) regulation of NMDAR currents . Positive_regulation EPHB2 DNM2 18442977 1921088 Inhibition of the signaling *blocked* 5-HT(2A/C) activation of [ERK] and the counteractive effect of 5-HT(2A/C) on 5-HT(1A) regulation of NMDAR currents . Positive_regulation EPHB2 DNM3 18442977 1921086 Inhibition of the signaling *blocked* 5-HT(2A/C) activation of [ERK] and the counteractive effect of 5-HT(2A/C) on 5-HT(1A) regulation of NMDAR currents . Positive_regulation EPHB2 DOK1 12087092 976463 Overexpression of or Dok1-Y361F , but not Dok1-6F , *suppressed* the [Ras/Erk] activation induced by glial cell line derived neurotrophic factor or RET-MEN2B , implying that this inhibitory effect requires the Ras-GTPase activating protein binding to Dok1 . Positive_regulation EPHB2 DRD1 15992362 1446867 Stimulation of the Gi-coupled neuropeptide Y1 and Gq-coupled muscarinic M1 acetylcholine receptors , but not the Gs-coupled , *led* to the activation of extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 DRD1 18614186 1936151 Delayed , context- and *dependent* activation of [ERK] in morphine sensitized mice . Positive_regulation EPHB2 DRD2 12435803 1015955 In PC12 cells that express D ( 2 ) DR , quinpirole elicited no change in PTP or MKP activity , whereas [ERK] was *activated* by stimulation . Positive_regulation EPHB2 DRD2 18940181 1989096 Roles of G protein and beta-arrestin in mediated [ERK] *activation* . Positive_regulation EPHB2 DRD2 18940181 1989097 [ERK] *activation* by ( D ( 2 ) R ) has been extensively characterized in various cell types including brain tissues . Positive_regulation EPHB2 DRD4 11562449 862831 In contrast , the transfection of N17Ras into D ( 4 ) MN9D cells blunted mediated [ERK] *activation* , indicating a Ras dependent mechanism . Positive_regulation EPHB2 DRD4 11562449 862835 All these indicate that distinct mechanisms mediate [ERK] and Akt/NF-kappa B *activation* by stimulation . Positive_regulation EPHB2 DRG1 15207334 1261477 Therefore , we suggest that after inflammation near the cell body , NGF synthesized within the nerve root and *induces* BDNF expression through trkA receptors and intracellular [ERK-MAPK] . Positive_regulation EPHB2 DRG1 16227886 1469940 [ERK] is *activated* by phosphorylation in the and spinal cord by noxious stimuli , which are related to pain hypersensitivity . Positive_regulation EPHB2 DRG1 17532077 1778376 Co-culture studies suggested that *activated* [ERK] in the dorsal horn . Positive_regulation EPHB2 DRG1 17532077 1778380 Brain derived neurotrophic factor (BDNF) activated ERK in the dorsal horn , and anti-BDNF blocked the *induced* [ERK] activation . Positive_regulation EPHB2 DRG1 17532077 1778384 These results suggest roles of BDNF in the induced [ERK] *activation* in the embryonic dorsal horn . Positive_regulation EPHB2 DRG2 15207334 1261478 Therefore , we suggest that after inflammation near the cell body , NGF synthesized within the nerve root and *induces* BDNF expression through trkA receptors and intracellular [ERK-MAPK] . Positive_regulation EPHB2 DRG2 16227886 1469941 [ERK] is *activated* by phosphorylation in the and spinal cord by noxious stimuli , which are related to pain hypersensitivity . Positive_regulation EPHB2 DRG2 17532077 1778377 Co-culture studies suggested that *activated* [ERK] in the dorsal horn . Positive_regulation EPHB2 DRG2 17532077 1778381 Brain derived neurotrophic factor (BDNF) activated ERK in the dorsal horn , and anti-BDNF blocked the induced [ERK] *activation* . Positive_regulation EPHB2 DRG2 17532077 1778385 These results suggest roles of BDNF in the *induced* [ERK] activation in the embryonic dorsal horn . Positive_regulation EPHB2 DSG1 23524970 2761889 Furthermore , [ERK] inhibition and the *induction* of differentiation markers by required both Erbin and DSG1 domains that participate in binding Erbin . Positive_regulation EPHB2 DST 18854640 2041186 rapidly *induced* activation of extracellular signal regulated kinase ( [ERK] ) 1/2 and p38 MAPK at 15 min , but the effect of BPA ( 10 microM ) on stimulation of cell growth was not blocked by pretreatment with inhibitors of MEK ( PD98059 ) or p38 ( SB203580 ) in a dose dependent manner . Positive_regulation EPHB2 DUSP1 23149933 2717931 downregulated by oxidized DJ-1 *activated* extracellular signal regulated kinase ( [ERK] ) and decreased apoptosis . Positive_regulation EPHB2 DUSP3 16845380 1592253 Our findings show that direct interaction of with VRK3 posttranslationally *regulates* [ERK] signalling . Positive_regulation EPHB2 DUSP6 14701731 1196027 However , the physiological roles of MKP-3 and the mechanism by which *regulates* Ras/Drosophila [ERK] ( DERK ) signaling in vivo have not been determined . Positive_regulation EPHB2 DUSP6 16247486 1508368 Introduction of LIGHT into ES cells results in the dephosphorylation of and *activation* of extracellular signal regulated kinase ( [ERK] ) 5 . Positive_regulation EPHB2 DUSP6 19106095 2031537 Moreover , activated [Erk] *induces* expression , leading to restoration of MKP3 levels after 1-2 h and a concomitant dephosphorylation of Erk in cells with activated PDGFRalpha . Positive_regulation EPHB2 DUSP6 19106095 2031538 Reducing the level by small interfering RNA *leads* to an increased [Erk] activation and mitogenic response to PDGF-BB . Positive_regulation EPHB2 DUSP6 22544520 2618724 Furthermore , inhibiting *increased* [ERK] activation and subsequently augmented the SPC induced hypopigmenting effects . Positive_regulation EPHB2 DUSP6 23023500 2684449 The defective [ERK] signaling was *caused* by the , whose protein expression increased with age due to a decline in repression by miR-181a . Positive_regulation EPHB2 DUSP9 18296638 1878895 Overexpression of in 3T3-L1 cells *inhibited* [ERK] and JNK phosphorylation and , to a lesser extent , p38MAPK phosphorylation . Positive_regulation EPHB2 DYRK1A 22923366 2719825 , a serine/threonine kinase , is *involved* in [ERK] and Akt activation in the brain of hyperhomocysteinemic mice . Positive_regulation EPHB2 DYRK1A 22923366 2719838 These observations demonstrate [ERK] and Akt activation *induced* by in the brain of hyperhomocysteinemic mice and open new perspectives to understand the basis of the cognitive defects in hyperhomocysteinemia . Positive_regulation EPHB2 E2F1 11371570 834858 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and [ERK] and *activation* of cAMP-responsive element binding protein ( CREB ) , NF-kappaB , and ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation EPHB2 E2F1 18396012 1899398 [ERK] activation is *regulated* by and is essential for E2F1 induced S phase entry . Positive_regulation EPHB2 E2F1 18396012 1899403 We demonstrate that *induces* [ERK] activation via a transcriptional mechanism and upregulates the expression of two guanine nucleotide exchange factors , RASGRP1 and RASGEF1B , which promote Ras activation . Positive_regulation EPHB2 E2F1 18396012 1899405 Furthermore , we show that *induced* [ERK] activity is essential for E2F1 induced S phase entry . Positive_regulation EPHB2 E2F2 11371570 834859 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and [ERK] and *activation* of cAMP-responsive element binding protein ( CREB ) , NF-kappaB , and ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation EPHB2 E2F3 11371570 834860 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and [ERK] and *activation* of cAMP-responsive element binding protein ( CREB ) , NF-kappaB , and ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation EPHB2 E2F4 11371570 834861 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and [ERK] and *activation* of cAMP-responsive element binding protein ( CREB ) , NF-kappaB , and ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation EPHB2 E2F5 11371570 834862 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and [ERK] and *activation* of cAMP-responsive element binding protein ( CREB ) , NF-kappaB , and ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation EPHB2 E2F6 11371570 834863 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and [ERK] and *activation* of cAMP-responsive element binding protein ( CREB ) , NF-kappaB , and ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation EPHB2 E2F7 11371570 834856 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and [ERK] and *activation* of cAMP-responsive element binding protein ( CREB ) , NF-kappaB , and ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation EPHB2 E2F8 11371570 834857 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and [ERK] and *activation* of cAMP-responsive element binding protein ( CREB ) , NF-kappaB , and ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation EPHB2 ECM1 16194881 1353358 We found that addition of beta1 and alpha(v)beta3 integrin blocking antibodies inhibited *induced* [ERK] activation , while addition of the MEK inhibitor PD98059 blocked ERK activation , serine phosphorylation of the osteogenic transcription factor runx2/cbfa-1 , osteogenic gene expression , and calcium deposition . Positive_regulation EPHB2 ECM1 18506372 1917973 from fibroblasts in UVB-SIPS *activates* FAK , [ERK] , and AKT in HaCaT cells . Positive_regulation EPHB2 ECM1 18506372 1917981 ERK and PI3K/AKT inhibitors inhibit *induced* [ERK] , AKT activation and cell proliferation . Positive_regulation EPHB2 ECM1 20507284 2315615 *dependent* mRNA expression profiles and phosphorylation patterns of p130Cas , FAK , [ERK] and p38 MAPK of osteoblast-like cells . Positive_regulation EPHB2 ECM2 16194881 1353359 We found that addition of beta1 and alpha(v)beta3 integrin blocking antibodies inhibited induced [ERK] *activation* , while addition of the MEK inhibitor PD98059 blocked ERK activation , serine phosphorylation of the osteogenic transcription factor runx2/cbfa-1 , osteogenic gene expression , and calcium deposition . Positive_regulation EPHB2 ECM2 18506372 1917974 from fibroblasts in UVB-SIPS *activates* FAK , [ERK] , and AKT in HaCaT cells . Positive_regulation EPHB2 ECM2 18506372 1917982 ERK and PI3K/AKT inhibitors inhibit *induced* [ERK] , AKT activation and cell proliferation . Positive_regulation EPHB2 ECM2 20507284 2315616 *dependent* mRNA expression profiles and phosphorylation patterns of p130Cas , FAK , [ERK] and p38 MAPK of osteoblast-like cells . Positive_regulation EPHB2 ECSCR 23393131 2764424 Silencing of *disrupts* VEGF induced KDR activation and AKT and [ERK] phosphorylation and impairs VEGF stimulated KDR degradation . Positive_regulation EPHB2 EDN1 10187821 602956 For example , nine point mutations within TM7 of the ETB were identified that prevented *stimulated* [ERK] activation . Positive_regulation EPHB2 EDN1 10487327 644584 ET-1 activated ERKs , which were followed by an increase in protein synthesis , and inhibition of protein kinase C activities by calphostin C completely suppressed the *induced* [ERK] activation . Positive_regulation EPHB2 EDN1 10487327 644587 These results suggest that protein kinase C and Raf-1 kinase , but not Src or Ras , are critical to *induced* [ERK] activation in cardiac myocytes . Positive_regulation EPHB2 EDN1 10737896 679633 Stimulation of these cells with bombesin , lysophosphatidic acid (LPA) , , and platelet derived growth factor ( PDGF ) *led* to a marked increase in the tyrosine phosphorylation of these focal adhesion proteins and in [ERK] activation . Positive_regulation EPHB2 EDN1 10807739 692270 Thus , the present study aimed to assess the role of ROS in *mediated* activation of c-Jun amino-terminal kinase (JNK) and extracellular signal regulated kinase ( [ERK] ) 1/2 . Positive_regulation EPHB2 EDN1 10807739 692271 JNK and [ERK] were *activated* by binding to a single receptor ( ET-1A ) but differed in their downstream mechanisms : only JNK activation was sensitive to the radical scavenger N-acetylcysteine and diphenylene iodonium , an inhibitor of NADPH oxidase , indicating a role for ROS . Positive_regulation EPHB2 EDN1 10960064 726342 Thrombin ( 0.3 and 3 u ml(-1) ) and bFGF ( 0.3 and 3 nM ) increased ERK activity for more than 2 h and increased cell number , whereas ( 100 nM ) transiently *stimulated* [ERK] activity and was non-mitogenic . Positive_regulation EPHB2 EDN1 11158304 781092 In transfection experiments , dominant negative N17Rac1 inhibited *activation* of [ERK] by , whereas activated V12Rac1 cooperated with c-Raf to activate ERK . Positive_regulation EPHB2 EDN1 11599124 870591 Furthermore , heparin and HS inhibited induced *activation* of extracellular signal regulated kinase ( [ERK] ) and phosphorylation of Elk-1 , which is one of the TCFs . Positive_regulation EPHB2 EDN1 11599124 870593 These results indicate that heparin and HS inhibited *induced* [ERK] activation , resulting in suppression of Elk-1 phosphorylation , and lead to inhibition of c-fos gene expression through SRF independent manner . Positive_regulation EPHB2 EDN1 11606208 871571 stimulation of wild-type ET ( A ) or ET ( B ) *induced* a fivefold to sixfold increase in [ERK] in COS-7 and CHO cells whereas full-length nonpalmitoylated ET ( A ) and ET ( B ) mutants failed to stimulate ERK . Positive_regulation EPHB2 EDN1 11606208 871572 Using mutated ET receptors with selective G-protein coupling we found that induced stimulation of G ( alpha ) q , but not of G ( alpha ) i or G ( alpha ) s , is *essential* for endothelin mediated [ERK] activation . Positive_regulation EPHB2 EDN1 11851354 913220 Role of EGF Receptor and Pyk2 in *induced* [ERK] activation in rat cardiomyocytes . Positive_regulation EPHB2 EDN1 11877323 919039 [ERK] *activation* by was rapid , concordant with the kinetics of ET-1 stimulated neutrophil aggregation . Positive_regulation EPHB2 EDN1 12055094 951672 These results suggest that both diacylglycerol-sensitive PKC , activated by PLC products , and diacylglycerol-insensitive PKC , possibly activated by a G ( i ) -PI 3-kinase dependent process , are involved in *induced* [ERK] activation . Positive_regulation EPHB2 EDN1 12055094 951674 Inhibition of Src kinases by PP1 abrogated phorbol ester- and *induced* [ERK] activation . Positive_regulation EPHB2 EDN1 12055094 951678 Altogether , our results indicate that *induces* [ERK] activation in rat myometrial cells through the sequential stimulation of PKC , Src , and Ras . Positive_regulation EPHB2 EDN1 12193071 980915 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( [ERK] ) and p38 mitogen activated protein (MAP) kinase were studied in rat and human renal glomerular mesangial cells . Positive_regulation EPHB2 EDN1 12193071 980997 induced a rapid and transient activation of Ras in renal mesangial cells , which was dependent upon the formation of the Shc/Grb2/Sos1 signalling complex and *resulted* in transient [ERK] activation . Positive_regulation EPHB2 EDN1 12475899 1037753 *induced* a rapid phosphorylation of the mitogen activated protein kinase [(MAPK)/ERK] and increased collagen I gene activity in freshly isolated aortas . Positive_regulation EPHB2 EDN1 12791183 1097641 Fourthly , *increased* the phosphorylated level of [ERK] and the expression of cylin D1 , an inhibitor of ERK blocked phosphorylated level of ERK and cyclin D1 expression . Positive_regulation EPHB2 EDN1 14530261 1174636 *stimulated* the phosphorylation of [ERK] and p38 alpha MAPK and induced the expression of COX-2 . Positive_regulation EPHB2 EDN1 14963006 1227899 PGI2 or iloprost at the IP receptor inhibited basal ERK phosphorylation with IC50 values of 10 nmol/L. Iloprost also attenuated the sustained activation of [ERK] *induced* by or basic fibroblast growth factor (bFGF) . Positive_regulation EPHB2 EDN1 15671081 1402457 Results of Western blot further demonstrated that *induced* [ERK] phosphorylation . Positive_regulation EPHB2 EDN1 15838308 1352939 Cytodifferentiation enhances [Erk] activation *induced* by in primary cultured astrocytes . Positive_regulation EPHB2 EDN1 15838308 1352940 On the contrary , the molar potency of ET-1 to induce accumulation of Ras-GTP was two orders of magnitude higher in DBcAMP treated astrocytes than in quiescent astrocytes , which was consistent with the case of *induced* [Erk] activation . Positive_regulation EPHB2 EDN1 16049167 1453744 Furthermore , NO directly inhibited *induced* [ERK] phosphorylation and activation in a cGMP dependent manner , indicating that NO modulates ET-1 induced c-fos expression via its inhibitory effect on ERK signaling pathway . Positive_regulation EPHB2 EDN1 16184402 1468214 These data indicate that trilinolein inhibits *induced* [ERK] phosphorylation , JNK phosphorylation , and c-fos gene expression via attenuating superoxide production in cardiomyocytes . Positive_regulation EPHB2 EDN1 16273641 1479700 *induced* phosphorylation of MLC and [ERK] , but not Akt . Positive_regulation EPHB2 EDN1 17113976 1651260 *Activation* of [ERK/RSK-1/CREB] by both and EGF was abolished by inhibition of Src , indicating its central role in ET-1 signaling in BAG cells . Positive_regulation EPHB2 EDN1 17113976 1651289 These data demonstrate that *causes* [ERK/RSK-1/CREB] phosphorylation predominantly through activation of G ( i ) and Src , with a minor contribution from MMP dependent EGF-R transactivation . Positive_regulation EPHB2 EDN1 17327470 1706646 Whereas the nonselective protein kinase C ( PKC ) inhibitor chelerythrine attenuated ET-1 induced cell proliferation , it was unable to block *induced* [ERK] phosphorylation . Positive_regulation EPHB2 EDN1 17707940 1800750 *induced* [ERK] phosphorylation was independent of integrin ligands , and an inhibitor of G ( q/11 ) , YM-254890 , as well as pertussis toxin , partially inhibited endothelin stimulated phosphorylation of Raf-1 and ERK . Positive_regulation EPHB2 EDN1 17707940 1800768 A PKC inhibitor and down-regulation of PKC prevented *induced* phosphorylation of paxillin and [ERK] . Positive_regulation EPHB2 EDN1 18322086 1881117 By using selective pharmacological inhibitors , we also provide evidence that ET-1 induces astrocyte proliferation and GFAP expression through activation of ERK- and JNK dependent pathways , consistent with the previous observation of *induced* activation of [ERK] ( Schinelli et al. , 2001 ) . Positive_regulation EPHB2 EDN1 18977218 1995150 Increased [ERK] phosphorylation was detected upon *stimulation* with Phenylephrine ( 2.6+/-0.1 times over basal ) , ( 1.8+/-0.2 ) , Dopamine ( 5.1+/-0.2 ) , TNF ( 9.8+/-0.7 ) or IL-4 ( 3.1+/-0.3 ) . Positive_regulation EPHB2 EDN1 19029977 1992447 ET ( A ) and ET ( B ) receptors , ERK-1/2 and MEK-1/2 protein expression and *stimulated* [ERK] phosphorylation were all increased in aortae from insulin treated diabetic rats . Positive_regulation EPHB2 EDN1 19207476 2033957 DY-9760e treatment with 3 microM totally and partially inhibited the induced CaMKII and [ERK] *activation* , respectively . Positive_regulation EPHB2 EDN1 19207476 2033958 The *induced* [ERK] activation was also partially blocked by a CaMKII inhibitor , KN93 . Positive_regulation EPHB2 EDN1 19207476 2033959 To confirm involvement of CaMKII activity in the [ERK] *activation* by and A23187 , cultured cardiomyocytes were transfected with a constitutively active CaMKII . Positive_regulation EPHB2 EDN1 19207476 2033960 Consistent with inhibitory actions of DY-9760e on the *induced* CaMKII and [ERK] activation , induction of hypertrophy related genes including atrial natriuretic peptide (ANP) and brain natriuretic peptide ( BNP ) was significantly inhibited by DY-9760e treatment . Positive_regulation EPHB2 EDN1 19207476 2033962 These results suggest that DY-9760e elicits antihypertrophic action on ET-1 induced cardiac hypertrophy through inhibition of CaMKII and ERK activation and that CaMKII activity in part mediates *induced* [ERK] activation . Positive_regulation EPHB2 EDN1 19675238 2119683 OPCs in vivo and in culture express functional ET ( A ) and ET ( B ) receptors , which mediate *induced* [ERK] ( extracellular signal regulated kinase ) and CREB ( cAMP response element binding protein ) phosphorylation . Positive_regulation EPHB2 EDN1 20026366 2217743 Mesenteric arteries isolated from such GK rats following treatment with losartan ( 25mg/kg/day for 2 weeks ) exhibited reduced ET-1- and Ang II-induced contractions , suppressed *stimulated* [ERK] phosphorylation , and increased ACh induced relaxation , while the rats exhibited normalized plasma NO metabolism and their mesenteric arteries exhibited increased basal NO formation . Positive_regulation EPHB2 EDN1 20929948 2337626 Conversely , *stimulates* [ERK] phosphorylation and Tbx5 expression in the early embryonic heart . Positive_regulation EPHB2 EDN1 22154739 2536495 In such aortas ( vs. those from age matched genetic control LETO rats ) : ( 1 ) the ET-1 induced contraction was enhanced , ( 2 ) the levels of HIF1a/ECE1/plasma ET-1 and plasma CML-AGEs were increased , ( 3 ) the *stimulated* [ERK] phosphorylation mediated by ET ( A ) -R was increased , ( 4 ) the expression level of Jab1 modified ET ( A ) -R protein was reduced , and ( 5 ) the expression level of O-GlcNAcylated ET ( A ) -R protein was increased . Positive_regulation EPHB2 EDN1 22154739 2536496 Aortas isolated from such OLETF rats that had been treated with AG ( 50mg/kg/day for 10 weeks ) exhibited reduced ET-1 induced contraction , suppressed *stimulated* [ERK] phosphorylation accompanied by down-regulation of ET ( A ) -R , and increased modification of ET ( A ) -R by Jab1 . Positive_regulation EPHB2 EDN1 22159081 2563194 Conversely , arrestin3 knockdown prevented ET ( A ) receptor desensitization and attenuated *stimulated* p38 and [ERK] signals , while arrestin2 depletion had no effect . Positive_regulation EPHB2 EDN1 22886408 2677777 Endothelium denuded aortas isolated from OLETF rats treated with pravastatin ( 10 mg/kg po , daily for 4 wk ) exhibited normalized ET-1 induced contractions and suppressed *stimulated* [ERK] phosphorylation , with the associated phosphorylated KSR1 and phosphorylated PP2A levels being increased toward normal levels . Positive_regulation EPHB2 EDN1 22935082 2719847 *induced* activation of [ERK] and collagen synthesis was , in contrast to corresponding effect of a muscarinic agonist , largely insensitive to pertussis toxin . Positive_regulation EPHB2 EDN1 8940174 399114 The observed ERK activation appeared to be mediated by heterotrimeric G proteins , since ectopic expression of a transducin alpha-subunit inhibited *stimulated* [ERK] activation . Positive_regulation EPHB2 EDN1 9453574 484272 Conversely , the *activation* of extracellular signal regulated kinase ( [ERK] ) by was largely inhibited in cells stably or transiently expressing nef . Positive_regulation EPHB2 EDN1 9453574 484273 Following chemokine receptor CXCR4 mediated infection of U373 cells stably expressing CXCR4 with the T-tropic HIV-1 strain m7-NDK , *induced* activation of [ERK] was also inhibited . Positive_regulation EPHB2 EDN1 9573527 502455 We have reported that both extracellular signal regulated kinase ( ERK ) and c-Jun NH2-terminal kinase (JNK) are activated by ET-1 and *induced* activation of [ERK] is inhibited by ANP . Positive_regulation EPHB2 EDN1 9870922 583159 *stimulated* [ERK] activation in airway smooth-muscle cells requires calcium influx and Raf activation . Positive_regulation EPHB2 EDN2 10187821 602957 For example , nine point mutations within TM7 of the ETB were identified that prevented *stimulated* [ERK] activation . Positive_regulation EPHB2 EDN2 10737896 679634 Stimulation of these cells with bombesin , lysophosphatidic acid (LPA) , , and platelet derived growth factor ( PDGF ) *led* to a marked increase in the tyrosine phosphorylation of these focal adhesion proteins and in [ERK] activation . Positive_regulation EPHB2 EDN2 11606208 871573 Using mutated ET receptors with selective G-protein coupling we found that endothelin induced stimulation of G ( alpha ) q , but not of G ( alpha ) i or G ( alpha ) s , is essential for mediated [ERK] *activation* . Positive_regulation EPHB2 EDN2 12193071 980916 The molecular mechanisms of dependent *activation* of extracellular signal regulated kinase ( [ERK] ) and p38 mitogen activated protein (MAP) kinase were studied in rat and human renal glomerular mesangial cells . Positive_regulation EPHB2 EDN2 12475899 1037754 *induced* a rapid phosphorylation of the mitogen activated protein kinase [(MAPK)/ERK] and increased collagen I gene activity in freshly isolated aortas . Positive_regulation EPHB2 EDN2 17707940 1800751 Endothelin induced ERK phosphorylation was independent of integrin ligands , and an inhibitor of G ( q/11 ) , YM-254890 , as well as pertussis toxin , partially inhibited *stimulated* phosphorylation of Raf-1 and [ERK] . Positive_regulation EPHB2 EDN2 17707940 1800769 A PKC inhibitor and down-regulation of PKC prevented *induced* phosphorylation of paxillin and [ERK] . Positive_regulation EPHB2 EDN2 8940174 399115 The observed ERK activation appeared to be mediated by heterotrimeric G proteins , since ectopic expression of a transducin alpha-subunit inhibited *stimulated* [ERK] activation . Positive_regulation EPHB2 EDN2 9870922 583160 *stimulated* [ERK] activation in airway smooth-muscle cells requires calcium influx and Raf activation . Positive_regulation EPHB2 EDN3 10187821 602958 For example , nine point mutations within TM7 of the ETB were identified that prevented *stimulated* [ERK] activation . Positive_regulation EPHB2 EDN3 10737896 679635 Stimulation of these cells with bombesin , lysophosphatidic acid (LPA) , , and platelet derived growth factor ( PDGF ) *led* to a marked increase in the tyrosine phosphorylation of these focal adhesion proteins and in [ERK] activation . Positive_regulation EPHB2 EDN3 11606208 871574 Using mutated ET receptors with selective G-protein coupling we found that induced stimulation of G ( alpha ) q , but not of G ( alpha ) i or G ( alpha ) s , is *essential* for endothelin mediated [ERK] activation . Positive_regulation EPHB2 EDN3 12193071 980917 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( [ERK] ) and p38 mitogen activated protein (MAP) kinase were studied in rat and human renal glomerular mesangial cells . Positive_regulation EPHB2 EDN3 12475899 1037755 *induced* a rapid phosphorylation of the mitogen activated protein kinase [(MAPK)/ERK] and increased collagen I gene activity in freshly isolated aortas . Positive_regulation EPHB2 EDN3 17707940 1800752 *induced* [ERK] phosphorylation was independent of integrin ligands , and an inhibitor of G ( q/11 ) , YM-254890 , as well as pertussis toxin , partially inhibited endothelin stimulated phosphorylation of Raf-1 and ERK . Positive_regulation EPHB2 EDN3 17707940 1800770 A PKC inhibitor and down-regulation of PKC prevented *induced* phosphorylation of paxillin and [ERK] . Positive_regulation EPHB2 EDN3 8940174 399116 The observed ERK activation appeared to be mediated by heterotrimeric G proteins , since ectopic expression of a transducin alpha-subunit inhibited *stimulated* [ERK] activation . Positive_regulation EPHB2 EDN3 9870922 583161 *stimulated* [ERK] activation in airway smooth-muscle cells requires calcium influx and Raf activation . Positive_regulation EPHB2 EFNB1 20170671 2228696 Furthermore , pre-treatment with PI3K inhibitor wortmannin or LY294002 prevented *induced* [ERK] activation in a dose dependent manner . Positive_regulation EPHB2 EFNB1 20633976 2316724 Identification of expression in prostatic mesenchyme and a *role* for [EphB-EphrinB] signalling in prostate development . Positive_regulation EPHB2 EFNB1 21653848 2442138 These data provide evidence for *induced* [EphB2] forward signaling in presynaptic structural plasticity during classical conditioning . Positive_regulation EPHB2 EFNB1 21932443 2506995 We used blue native PAGE and MS to analyze the transient protein-protein interactions that resulted from the *stimulation* of [EphB2] receptors by their ligands . Positive_regulation EPHB2 EFNB1 21952679 2488092 In addition , [EphB2] and EphB3 play a cell-autonomous role in regulating the transitions of double negative to double positive cells and of double positive to single positive thymocytes and the lack of these molecules or their ligands and ephrin B2 *induces* profound alterations of the TEC maturation and in the arrangement of epithelial network . Positive_regulation EPHB2 EFNB1 22475621 2715227 *Activation* of [EphB] receptors by ( efnB ) ligands on neuronal cell surface regulates important functions , including neurite outgrowth , axonal guidance , and synaptic plasticity . Positive_regulation EPHB2 EFNB1 23147113 2722902 Taken together , our findings suggest that *activated* [EphB2] receptors recruit a novel Nck/Pak signaling complex to mediate repulsive cortical growth cone guidance , which may be relevant for EphB forward signaling dependent axon guidance in vivo . Positive_regulation EPHB2 EFNB2 12039842 954236 not only *increased* the phosphorylation of [EphB2] and EphB4 in a time dependent manner but also increased recruitment of p120-Ras-GTPase activating protein ( p120-RasGAP ) to EphB2 and EphB4 . Positive_regulation EPHB2 EFNB2 14691139 1179839 We show further that a kinase-defective , truncating mutation in EphB2 also results in abnormal spine development and that mediated *activation* of the [EphB] receptors accelerates dendritic spine development . Positive_regulation EPHB2 EFNB2 18713744 1974758 We found that [EphB2] is cleaved by MMPs both in vitro and in vivo , and that this cleavage is *induced* by interaction with its ligand . Positive_regulation EPHB2 EFNB2 21653848 2442139 These data provide evidence for *induced* [EphB2] forward signaling in presynaptic structural plasticity during classical conditioning . Positive_regulation EPHB2 EFNB2 21952679 2488093 In addition , [EphB2] and EphB3 play a cell-autonomous role in regulating the transitions of double negative to double positive cells and of double positive to single positive thymocytes and the lack of these molecules or their ligands ephrin B1 and *induces* profound alterations of the TEC maturation and in the arrangement of epithelial network . Positive_regulation EPHB2 EFNB2 22475621 2715228 *Activation* of [EphB] receptors by ( efnB ) ligands on neuronal cell surface regulates important functions , including neurite outgrowth , axonal guidance , and synaptic plasticity . Positive_regulation EPHB2 EFNB2 23147113 2722903 Taken together , our findings suggest that *activated* [EphB2] receptors recruit a novel Nck/Pak signaling complex to mediate repulsive cortical growth cone guidance , which may be relevant for EphB forward signaling dependent axon guidance in vivo . Positive_regulation EPHB2 EFNB3 21653848 2442140 These data provide evidence for *induced* [EphB2] forward signaling in presynaptic structural plasticity during classical conditioning . Positive_regulation EPHB2 EFNB3 22475621 2715229 *Activation* of [EphB] receptors by ( efnB ) ligands on neuronal cell surface regulates important functions , including neurite outgrowth , axonal guidance , and synaptic plasticity . Positive_regulation EPHB2 EFNB3 23147113 2722904 Taken together , our findings suggest that *activated* [EphB2] receptors recruit a novel Nck/Pak signaling complex to mediate repulsive cortical growth cone guidance , which may be relevant for EphB forward signaling dependent axon guidance in vivo . Positive_regulation EPHB2 EFS 21087357 2376918 U0126 blocked the effect of LPS on acetylcholine , prostaglandin E ( 2 ) , KCl , and *induced* contractions , the levels of carbonyls and MDA+4-HDA and [p-ERK] and COX-2 expression . Positive_regulation EPHB2 EGF 10224087 609963 Transfection studies in COS-1 cells demonstrated that in vivo phosphorylation of *stimulated* [ERK] depended on VHR protein levels . Positive_regulation EPHB2 EGF 10353601 617624 In Panc-1 cells , FTS at a concentration of 25-100 microM reduced the amount of Ras in a dose dependent manner and interfered with serum dependent and *stimulated* [ERK] activation , thus inhibiting both anchorage dependent and anchorage independent growth of Panc-1 cells in vitro . Positive_regulation EPHB2 EGF 10383890 624664 In normal epithelium , *stimulated* an early rise in [ERK] activity at 4 min followed by a rapid decline , whereas a sustained ( 1 h ) elevation of ERK activity was observed in the tumor cells . Positive_regulation EPHB2 EGF 10383890 624666 The MEK inhibitor , PD 098059 inhibited *stimulated* proliferation and [ERK] activity in a parallel , dose dependent manner showing that ERK activation is at least permissive for the proliferative response to EGF . Positive_regulation EPHB2 EGF 10400627 628248 Here we show that the *mediated* [ERK] activation is abolished by loss of Grb2 , whereas this response is not affected by loss of Shc . Positive_regulation EPHB2 EGF 10446212 636418 We contrasted the effects of nitric oxide on [ERK] *activation* by angiotensin II and , since the transactivation of the EGF receptor has been implicated as a response to angiotensin II . Positive_regulation EPHB2 EGF 10446212 636423 The tyrphostin AG1478 , known to inhibit EGF receptor phosphorylation , also inhibited the angiotensin II and induced *activation* of [ERK] , the phosphorylation of the EGF receptor , and the subsequent association of Shc and Grb2 . Positive_regulation EPHB2 EGF 10503724 648814 *activates* extracellular signal regulated protein kinases ( [ERK] ) in freshly isolated porcine granulosa cells . Positive_regulation EPHB2 EGF 10503724 648815 These data indicate that *stimulates* active [ERK] in a time- and concentration dependent manner in freshly isolated pGCs and that this experimental approach represents an effective manner with which to evaluate the role of EGF and the ERK signal transduction pathway in freshly harvested pGC . Positive_regulation EPHB2 EGF 10541432 563436 Kinase-deficient erbB proteins reduced epidermal growth factor (EGF) induced tyrosine phosphorylation of endogenous Shc proteins and also reduced immediate and sustained *induced* [ERK] MAPK activities in human glioblastoma cells , although basal ERK MAPK activities were unaffected . Positive_regulation EPHB2 EGF 10608465 575275 Epidermal growth factor (EGF) also stimulated the activity of ERK , in both WKY and SHR cells , but nor of JNK or p38 , with *stimulation* of [ERK] activity by occurring more rapidly in SHR cells than in those from WKY rats . Positive_regulation EPHB2 EGF 10617690 657232 *increased* the activation of extracellular signal regulated kinase ( [ERK] ) and c-Jun amino terminal kinase (JNK) in a time dependent manner . Positive_regulation EPHB2 EGF 10647963 578006 Activation of [ERK] in *response* to or PMA was also reduced in cortical brain slices of 24-month-old rats . Positive_regulation EPHB2 EGF 10688043 669948 dramatically *increased* [ERK] phosphorylation while DHT did not . Positive_regulation EPHB2 EGF 10751319 681514 However , dependent *activation* of endogenous [Erk] did not account for most of the Sp1 kinase activity , since Erk and additional Sp1 kinase activity analyzed in a solid-phase kinase assay eluted from an ion-exchange column in different fractions . Positive_regulation EPHB2 EGF 10797308 689849 Both and Cpd 5 *caused* an induction of [phospho-extracellular response kinase (ERK)] , which was also more sustained with Cpd 5 . Positive_regulation EPHB2 EGF 10965882 728026 In the presence of a NADH/NADPH oxidase inhibitor , diphenyleneiodonium ( DPI ) or an antioxidant , alpha-tocopherol , Ang II-induced protein tyrosine phosphorylation of two major proteins ( p120 , p70 ) and ERK activation were markedly reduced , whereas [ERK] *activation* by was unaffected . Positive_regulation EPHB2 EGF 10989284 732642 Chronic treatment with micro or kappa opioid agonists ( > /=2 h ) inhibits *induced* [ERK] activation in opioid receptor overexpressing COS-7 cells . Positive_regulation EPHB2 EGF 11018025 752773 Calcium induced ERK activation differed in kinetics from mitogenic [ERK] *activation* by and could be modulated by alterations of intracellular calcium levels . Positive_regulation EPHB2 EGF 11046147 743136 In contrast , fails to promote a morphogenic program and *induces* transient Gab1 phosphorylation and [Erk] activation . Positive_regulation EPHB2 EGF 11048648 743157 Here we also report that ethanol inhibits activation of [ERK] *induced* by both and PDGF . Positive_regulation EPHB2 EGF 11116149 810650 Metalloprotease dependent receptor activation is *required* for activation of [ERK] and p38 MAPK but not for JNK . Positive_regulation EPHB2 EGF 11123423 762771 *induced* cell proliferation through [ERK] phosphorylation , since U0126 , which is an inhibitor of ERK phosphorylation , abrogated the increase of cyclin D1 by EGF . Positive_regulation EPHB2 EGF 11134020 794906 Overexpression of N-acetylglucosaminyltransferase III enhances the *induced* phosphorylation of [ERK] in HeLaS3 cells by up-regulation of the internalization rate of the receptors . Positive_regulation EPHB2 EGF 11134020 794911 Although the binding of EGF to the epidermal growth factor receptor (EGFR) was decreased in GnT-III transfectants to a level of about 60 % of control cells , the *induced* activation of extracellular signal regulated kinase ( [ERK] ) in GnT-III transfectants was enhanced to approximately 1.4-fold that of the control cells . Positive_regulation EPHB2 EGF 11134020 794913 These results suggest that GnT-III overexpression in HeLaS3 cells resulted in an enhancement of *induced* [ERK] phosphorylation at least in part by the up-regulation of the endocytosis of EGFR . Positive_regulation EPHB2 EGF 11149911 780468 The additional finding that *induces* [ERK] and EGR-1 in a PKC independent manner and that this signal is not sufficient to up-regulate TF emphasizes the importance of a VEGF-specific signaling pattern for the induction of TF . Positive_regulation EPHB2 EGF 11162642 782344 Moreover , H ( 2 ) O ( 2 ) stimulates EGF receptor tyrosine phosphorylation and receptor inhibitors *attenuated* H ( 2 ) O ( 2 ) -induced [ERK] activation . Positive_regulation EPHB2 EGF 11164710 782638 The stimulation of [ERK] and JNK *induced* by was observed earlier than the stimulation of p38 and JNK induced by UVB . Positive_regulation EPHB2 EGF 11262401 818820 In contrast to IGF-1 , AICAR did not block *dependent* Raf-1 and [Erk] activation , but our results demonstrated that multiple Raf-1 upstream pathways induced by EGF were differentially affected by AICAR : inhibition of Ras activation and simultaneous induction of Ras independent Raf activation . Positive_regulation EPHB2 EGF 11341977 812609 In contrast , [ERK] phosphorylation *induced* by EGF activated normal receptor in the same cells was largely unaffected by treatment with phosphoinositide 3-kinase inhibitors . Positive_regulation EPHB2 EGF 11341977 812610 EGFRvIII activation of ERKs was also sensitive to the phospholipase C inhibitor U73122 , whereas [ERK] *activation* by normal receptor was not . Positive_regulation EPHB2 EGF 11495895 860833 Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor- but not *induced* [ERK] activation . Positive_regulation EPHB2 EGF 11495895 860856 Expression of dominant negative Sprouty2 and Sprouty4 enhanced and prolonged FGF- but not *induced* [ERK] activation in 293 cells . Positive_regulation EPHB2 EGF 11681720 873914 GH induced tyrosine phosphorylation of EGF receptor and JAK2 in cardiac myocytes , and an receptor inhibitor tyrphostin AG1478 and a JAK2 inhibitor tyrphostin B42 completely *inhibited* GH-induced [ERK] activation . Positive_regulation EPHB2 EGF 11739023 885990 Pre-treatment of alpha T3-1 cells with the specific MAPK kinase ( MEK ) inhibitor , U0126 , blocked PACAP and *induced* activation of [ERK] . Positive_regulation EPHB2 EGF 11758828 887690 We examined whether is *involved* in [ERK] activation and whether ERK activation triggers epithelial proliferation in PHT gastric mucosa . Positive_regulation EPHB2 EGF 11851354 913221 *Role* of Receptor and Pyk2 in endothelin-1 induced [ERK] activation in rat cardiomyocytes . Positive_regulation EPHB2 EGF 11875120 918882 Sucrose and PAO also inhibited EGFinduced internalization of the EGF-R in C9 cells , and the inability of these agents to impair *induced* [ERK] activation suggested that the latter is also independent of receptor endocytosis . Positive_regulation EPHB2 EGF 11896055 944404 We have examined the ability of *stimulated* [ERK] activation to regulate Grb2 associated binder-1 (Gab1)/phosphatidylinositol 3-kinase (PI3K) interactions . Positive_regulation EPHB2 EGF 11896055 944427 SHP2 is shown to associate with and dephosphorylate Gab1 , suggesting that *stimulated* [ERK] might act through the regulation of SHP2 . Positive_regulation EPHB2 EGF 11926263 926754 NS-417 also enhanced [ERK] activation *induced* by 10 minutes stimulation with NGF , bFGF or in PC12 cells . Positive_regulation EPHB2 EGF 11950234 930294 *stimulated* receptor internalization , [ERK] protein phosphorylation and intracellular calcium mobilization . Positive_regulation EPHB2 EGF 12037663 949290 The activation of hTERT mRNA expression by EGF was specifically blocked by MEK inhibitor , and in vitro kinase assays demonstrated that [ERK] is activated in *response* to . Positive_regulation EPHB2 EGF 12221251 987606 In contrast , *activation* of extracellular signal regulated kinase ( [ERK] ) 1/2 by ( 1 nmol/L ) was significantly inhibited by red wine polyphenols ( 6 mmol/L ) . Positive_regulation EPHB2 EGF 12376555 996889 TGF-beta1 only partially inhibited *induced* [Erk] phosphorylation . Positive_regulation EPHB2 EGF 12384223 998624 Moreover , we show that the signaling cascade initiated by substance P or EGF are indistinguishable , including the activation of the receptor , the *activation* of [ERK] , and the final stimulation of Egr-1 biosynthesis . Positive_regulation EPHB2 EGF 12454035 1020970 To investigate the role of protein kinase C ( PKC ) isozymes in *induced* activation of extracellular signal regulated kinase ( [ERK] ) and cell proliferation in cultured human corneal epithelial cells . Positive_regulation EPHB2 EGF 12454035 1020971 The PKC inhibitor GF109203X inhibited PMA induced , but not basal or *induced* , phosphorylation of [ERK] , whereas the EGF receptor inhibitor tyrphostin AG1478 blocked basal and EGF- , but not PMA- , induced phosphorylation of ERK . Positive_regulation EPHB2 EGF 12454035 1020972 Although activation of PKC by PMA results in activation of ERK , *induced* phosphorylation of [ERK] and/or cell proliferation is independent of the conventional and novel isozymes PKC-alpha , -betaI , -betaII , -delta , and - epsilon in human corneal epithelial cells . Positive_regulation EPHB2 EGF 12467906 1022500 However , *induced* [ERK] activation was not affected by Bainiku-ekisu . Positive_regulation EPHB2 EGF 12566304 1054560 *stimulated* phosphorylation of [ERK] and Bad is blocked by pretreatment with U0126 , a selective MAP kinase kinase (MKK)1/2 inhibitor . Positive_regulation EPHB2 EGF 12633740 1068256 The effect of UVA was investigated on the *induced* activation of the signaling kinase [ERK] and the transcription factors AP1 , NFkappaB , and STAT1 . Positive_regulation EPHB2 EGF 12633740 1068257 UVA prevented the *induced* stimulation of [ERK] in a dose dependent manner within the range of 1.5-9 J/cm ( 2 ) . Positive_regulation EPHB2 EGF 12692126 1099968 Bombesin , lysophosphatidic acid , and rapidly *stimulate* focal adhesion kinase phosphorylation at Ser-910 : requirement for [ERK] activation . Positive_regulation EPHB2 EGF 12700650 1082048 All these findings suggest that epidermoid tumor cells counteract the IFNalpha induced apoptosis through a survival pathway that involves the hyperactivation of the *dependent* Ras- > [Erk] signalling . Positive_regulation EPHB2 EGF 12706116 1082479 In PC12 cells , NGF and *induce* a rapid translocation of [GFP-Erk] that requires Ras and Mek . Positive_regulation EPHB2 EGF 12750372 1119626 [ERK] activation by GnRHR is *mediated* by the receptor , which activates Ras either directly or via c-Src . Positive_regulation EPHB2 EGF 12753285 1089637 *stimulated* the phosphorylation of [ERK] and Raf-1 in both ADPKD and HKC cells , but had no effect on B-Raf . Positive_regulation EPHB2 EGF 12765417 1094010 LPA and both *activated* [ERK] but had no synergistic effect when combined . Positive_regulation EPHB2 EGF 12767047 1094248 In hepatocytes at 24 h of culturing ( mid/late G ( 1 ) ) with 20,000 cells per cm ( 2 ) , *induced* strong phosphorylation of the EGF receptor , as well as Shc and [ERK] , and stimulated DNA synthesis , but did not activate Stat5b , although the Stat5b response to GH or PRL was retained . Positive_regulation EPHB2 EGF 12782152 1095845 In contrast , [ERK] *activation* by in both cell types was not sensitive to n-butanol . Positive_regulation EPHB2 EGF 12876381 1115375 Using cultured rat hepatocytes , we here show that receptor stimulation in mid/late G ( 1 ) phase *caused* a sustained [ERK] activation that lasted for at least 48 h. Inhibition of the early part of this activity by a single addition of the MEK inhibitor PD98059 did not affect the DNA synthesis . Positive_regulation EPHB2 EGF 12926057 1131573 Gab1 is a pleckstrin homology (PH) domain containing docking protein that mediates *induced* [Erk] and Akt/PKB activation . Positive_regulation EPHB2 EGF 12952932 1137480 Conversely , *induced* [ERK] activation spreads throughout the cell body after EGF bead stimulation . Positive_regulation EPHB2 EGF 14505571 1144935 The role played by Cdc42 in regulating the timing of EGF receptor-Cbl interactions is underscored by the fact that constitutively active Cdc42 ( F28L ) , by persistently blocking the binding of Cbl to these receptors , leads to their aberrant accumulation and sustained *stimulated* [ERK] activation , thus resulting in cellular transformation . Positive_regulation EPHB2 EGF 14551200 1175543 Experiments involving the expression of the dominant negative mutants of Ras and Rap1 signaling ( RasN17 or Rap1N17 ) indicate that both GTPases Ras and Rap1 are recruited for the ERK activation by VIP and PACAP38 , whereas Rap1 is poorly involved in TRH or *induced* [ERK] activation . Positive_regulation EPHB2 EGF 14560016 1154082 Moreover , Cbl-3 was not required for attenuation of *stimulated* [Erk] activation in primary keratinocytes . Positive_regulation EPHB2 EGF 14576170 1199912 Consistent with this , the *mediated* [ERK] activation was blocked in GnT-III transfectants . Positive_regulation EPHB2 EGF 14600156 1187522 receptor blockade *attenuated* [ERK] activation , but not NHE-1 activation by 5-HT and Ang II , suggesting that the EGF receptor and NHE-1 work in parallel to stimulate ERK activity in RASM cells , converging distal to the EGF receptor but at or above the level of Ras in the Ras-MEK-ERK pathway . Positive_regulation EPHB2 EGF 14612544 1163370 The SQ20B head and neck squamous carcinoma cell line demonstrated loss of *dependent* AKT and [ERK] activation even at low doses of inhibitor . Positive_regulation EPHB2 EGF 14645669 1173049 Prolonged DAMGO exposure induced EGFR internalization/down-regulation , did not activate ERK , and inhibited exogenous *stimulated* [ERK] phosphorylation . Positive_regulation EPHB2 EGF 14645669 1173055 However , long-term application of U69 ,593 neither down-regulated EGFR nor inhibited *induced* [ERK] activation . Positive_regulation EPHB2 EGF 14660603 1202122 Because Ras participates in [Erk] *activation* by , we tested whether Ras methylation regulates Erk activation . Positive_regulation EPHB2 EGF 14660603 1202123 Transient transfection of human prenylcysteine directed carboxyl methyltransferase increased *stimulated* [Erk] activation . Positive_regulation EPHB2 EGF 14660603 1202133 However , when COS-1 cells were transfected with Ras complexed to CD8 , plasma membrane localization of Ras was unaffected by AFC , yet *stimulated* [Erk] activation was inhibited by AFC . Positive_regulation EPHB2 EGF 14665621 1210826 Inhibition of Src tyrosine kinase activity abrogated *stimulated* [Erk] activation and cell migration . Positive_regulation EPHB2 EGF 14665621 1210828 Together , these results reveal that Gab1 recruits SHP2 to dephosphorylate paxillin , leading to dissociation of Csk from the paxillin-Src complex and Src activation and that Src is an SHP2 effector involved in *stimulated* [Erk] activation and cell migration . Positive_regulation EPHB2 EGF 14714610 1181711 treatment significantly *induced* [ERK] activity ( peaked at 30 min ) and significantly increased COX-2 protein ( peaked at 6 hr ) , production of prostaglandin E2 ( PGE2 ) , and cell proliferation . Positive_regulation EPHB2 EGF 15028221 1222956 For example , the mitogen *induces* a transient [ERK] activation , whereas the neurotrophin NGF induces prolonged ERK activation . Positive_regulation EPHB2 EGF 15028221 1222960 We show that the scaffold/adaptor protein CNK2/MAGUIN-1 is required for NGF- but not *induced* [ERK] activation . Positive_regulation EPHB2 EGF 15150258 1252316 However , *activation* of [ERK] by or carbachol were not suppressed by inhibition of CaMKK , indicating specificity for this `` cross-talk . '' Positive_regulation EPHB2 EGF 15235105 1281970 In the presence of PI3K inhibitors ( Wortmannin ) , EGF stimulated trophoblast migration and phosphorylation of AKT and P70S6K ( Thr ( 389 ) and Thr ( 421 ) /Ser ( 424 ) ) were decreased , while *induced* [ERK] phosphorylation was not affected . Positive_regulation EPHB2 EGF 15252117 1274281 *dependent* activation of [ERK] and serum response element ( SRE ) are both up-regulated in PC12 cells stably overexpressing PLC-gamma1 , but knockdown of PLC-gamma1 by siRNA significantly reduces ERK activation . Positive_regulation EPHB2 EGF 15310281 1285075 The addition of SB203580 prolonged the transient *activation* of both B-Raf and [ERK] by alone . Positive_regulation EPHB2 EGF 15389644 1359168 NT stimulated ERK activation via a protein kinase C ( PKC ) -dependent ( but EGF receptor independent ) pathway in PANC-1 and MIA PaCa-2 cells , whereas *promoted* [ERK] activation through a PKC independent pathway in these cells . Positive_regulation EPHB2 EGF 15464054 1305000 induced [ERK] *activation* is mediated by EGF receptor type 1 while opioid receptor activation seems to brings about stimulation via EGF receptor type . Positive_regulation EPHB2 EGF 15492213 1325230 grb2-/hypomorph murine embryonic fibroblasts ( MEFs ) show decreased activation of both PKB and [Erk] upon *stimulation* with , whereas grb2-/hypomorph ; Positive_regulation EPHB2 EGF 15496479 1359576 Wounding of the IEC-6 monolayer induced transient [ERK] activation , which was further *enhanced* by . Positive_regulation EPHB2 EGF 15498824 1366999 RES pretreatment attenuated ERK phosphorylation when CFs were stimulated with 0.2 nM epidermal growth factor (EGF) , a concentration at which *induced* [ERK] activation over basal was similar to the phosphorylation induced by 100 nM ANG II . Positive_regulation EPHB2 EGF 15572377 1368349 We found that HER2 mediated effects on EGFR dimerization and trafficking were sufficient to explain the observed HER2 mediated amplification of *induced* [ERK] signaling . Positive_regulation EPHB2 EGF 15615697 1380848 Moreover , the effect of Src family kinase inhibitors on *stimulated* [ERK] phosphorylation was transient , prompting a search for other targets of Src family kinase action . Positive_regulation EPHB2 EGF 15634347 1362564 We illustrate and validate these principles experimentally : ( a ) a kinase inhibitor affects the amplitude of *induced* [ERK] phosphorylation much more than its duration and ( b ) a phosphatase inhibitor influences both signal duration and signal amplitude , in particular long after EGF administration . Positive_regulation EPHB2 EGF 15640153 1381326 PGEs enhanced [Erk] activation and MMP-1 secretion in *response* to but inhibited Erk and MMP-1 when TNF-alpha and IL-1beta were the stimuli , indicating that the effects of PGEs on gastric cell responses are context dependent . Positive_regulation EPHB2 EGF 15659382 1381895 Suppression of *induced* [Erk] activation by specific inhibitor or by the dominant expression of a silent Erk mutant effectively abolished the effects of EGF stimulation on regulations of CTCF and pax6 . Positive_regulation EPHB2 EGF 15689414 1402586 However , inhibition of receptor phosphorylation by the tyrphostin AG-1478 only partially *attenuated* isoproterenol induced [ERK] phosphorylation , whereas EGF-responsive ERK activation was completely blocked . Positive_regulation EPHB2 EGF 15703833 1372696 I-2PP2A/SET suppressed activation of [ERK] *following* stimulation but did not affect activation levels of stress kinases , JNK and p38 . Positive_regulation EPHB2 EGF 15720812 1351914 Both Akt and [ERK] were rapidly phosphorylated in *response* to , with ERK phosphorylation being the weakest in PC3 cells . Positive_regulation EPHB2 EGF 15850570 1399250 In contrast to [ERK] activation *mediated* by the , ERK activation by peroxynitrite was not prevented by AG1478 ( EGF receptor inhibitor ) . Positive_regulation EPHB2 EGF 15878157 1411320 Ethanol inhibited *induced* EGFR autophosphorylation , phosphorylation of [ERK] as well as Akt and its substrate GSK-3beta , and subsequently blocked EGF stimulated AP-1 activation in B82L cells . Positive_regulation EPHB2 EGF 15881653 1406431 In comparison , LY294002 treatment had no effect on [ERK] *activation* by , but the chemotactic response was reduced at all the concentrations of EGF tested indicating that NGF and EGF differed in the utilization of ERK and PI3-K to signal chemotaxis in PC12 cells . Positive_regulation EPHB2 EGF 15888452 1419478 We show that Cdc2 inhibits mediated [ERK] *activation* through direct interaction and phosphorylation of several ERK pathway proteins , including the guanine nucleotide exchange factor , Sos-1 , and Raf-1 kinase . Positive_regulation EPHB2 EGF 15940262 1445899 Expression of annexin A6 in A431 cells reduced , while RNAi mediated suppression of annexin A6 in HeLa cells enhanced *induced* Ras and [Erk] activation . Positive_regulation EPHB2 EGF 15952937 1452239 Gab1-SHP2 interaction has been shown to mediate [ERK] ( extracellular-signal regulated kinase ) *activation* by ( epidermal growth factor ) . Positive_regulation EPHB2 EGF 15952937 1452240 Using T47D and MCF-7 human breast carcinoma cells that express endogenous Gab1 and Gab2 , we examined the role of these docking proteins in *induced* [ERK] activation . Positive_regulation EPHB2 EGF 15952937 1452246 Expression of either SHP2 binding defective Gab1 or Gab2 mutant blocked *induced* [ERK] activation . Positive_regulation EPHB2 EGF 16077899 1442319 Regulation of *induced* [ERK/MAPK] activation and EGFR internalization by G protein coupled receptor kinase 2 . Positive_regulation EPHB2 EGF 16077899 1442348 Western blotting assay shows that EGF induced ERK/MAPK phosphorylation increases 1.9-fold , 1.1-fold and 1.5-fold ( P < 0.05 ) at time point 30 , 60 and 120 min , respectively when the cells were transfected with GRK2 , suggesting the regulatory role of GRK2 on *induced* [ERK/MAPK] activation . Positive_regulation EPHB2 EGF 16077899 1442378 Overall , these data suggest that GRK2 has a regulatory role in *induced* [ERK/MAPK] activation , and that the mechanisms underlying the modulatory role of GRK2 in EGFR and GPCR signaling pathways are somewhat different at least in receptor internalization . Positive_regulation EPHB2 EGF 16135787 1450365 In addition , both knockdown and overexpression of IQGAP1 reduced *stimulated* activation of MEK and [ERK] . Positive_regulation EPHB2 EGF 16150920 1539191 also *induced* robust [ERK] activation in primary porcine mesenchymal stem cells . Positive_regulation EPHB2 EGF 16253990 1508455 In monolayer culture , expression of Gab2 at levels comparable with those detected in human breast cancer cells accelerated epidermal growth factor (EGF) induced cell cycle progression and was associated with increased basal Stat5 tyrosine phosphorylation and enhanced and/or more sustained *induced* [Erk] and Akt activation . Positive_regulation EPHB2 EGF 16394028 1553985 increased cell motility , enhanced the activities of secreted pro-matrix metalloproteinase (MMP)-2 and -9 , and *enhanced* expression and activation of [Erk] and integrin linked kinase (ILK) . Positive_regulation EPHB2 EGF 16441665 1516851 MVP overexpression downregulates *dependent* [ERK] activation in Src overexpressing cells . Positive_regulation EPHB2 EGF 16517240 1530827 Paradoxically , beta1 integrin stimulation increased *induced* [Erk] activation while increasing expression of the inhibitory p66ShcA isoform . Positive_regulation EPHB2 EGF 16585180 1544132 In Mgat5 mutant and wild-type carcinoma cells , DAM-1976 enhanced and prolonged TGF-beta- and dependent Smad2/3 and [Erk] *activation* , respectively . Positive_regulation EPHB2 EGF 16702953 1631391 We previously reported that SNT-2 is not tyrosine phosphorylated significantly in response to epidermal growth factor (EGF) but that it inhibits [ERK] *activation* via stimulation by forming a complex with ERK2 . Positive_regulation EPHB2 EGF 16709244 1589890 In addition , activation of [ERK] downstream of Vav1 is *dependent* on autocrine receptor stimulation while active Vav1 can stimulate Rac1 and PAK activation independent of ligand binding to the EGF receptor . Positive_regulation EPHB2 EGF 16785991 1654019 PRL acutely activated JAK2 , signal transducer and activator of transcription-5 ( STAT5 ) , and extracellular signal regulated kinase-1 and -2 ( ERK1 and ERK2 ) , whereas *caused* EGFR activation and consequent src homology collagen (SHC) activation and [ERK] activation . Positive_regulation EPHB2 EGF 16785991 1654030 Our data suggest that PRL synergistically augments signaling in T47D breast cancer cells at least in part by lessening EGF induced EGFR downregulation and that this effect *requires* PRL induced [ERK] activity and threonine phosphorylation of EGFR . Positive_regulation EPHB2 EGF 16855393 1588676 Both basal and *stimulated* [ERK] activation were suppressed in hsf1-/- cells at the edge of the scratch . Positive_regulation EPHB2 EGF 17043637 1724405 In *response* to , these cells demonstrated equivalent overall EGFR tyrosine phosphorylation and [ERK/MAP] kinase activation ; Positive_regulation EPHB2 EGF 17084704 1643686 This effect is propagated to downstream elements of the pathway as reflected by sustained *induced* [ERK] phosphorylation and enhanced SRE dependent transcription . Positive_regulation EPHB2 EGF 17113976 1651197 Whereas , selective inhibition of EGF-R kinase with AG1478 caused complete inhibition of induced [ERK/RSK-1/CREB] *activation* , it caused only partial reduction ( 30-40 % ) of such ET-1 induced responses . Positive_regulation EPHB2 EGF 17113976 1651261 *Activation* of [ERK/RSK-1/CREB] by both ET-1 and was abolished by inhibition of Src , indicating its central role in ET-1 signaling in BAG cells . Positive_regulation EPHB2 EGF 17348021 1748226 The loss of MMP expression is associated with a suppression of *induced* [Erk] and Jnk activities , and AP-1 DNA binding and transactivation capacities . Positive_regulation EPHB2 EGF 17372305 1713800 Both low and high *activated* [ERK] and p38 in preadipocytes . Positive_regulation EPHB2 EGF 17372305 1713807 Src inhibitors PP1 and PP2 blocked [ERK] and p38 activation by low but not high EGF , and only high *increased* Shc phosphorylation . Positive_regulation EPHB2 EGF 17372305 1713810 Selective inhibition of the with AG1478 *blocked* [ERK] and p38 activation at both concentrations ; Positive_regulation EPHB2 EGF 17374607 1734752 Axin inhibits cellular proliferation and [ERK] pathway activation *induced* by either or Ras , indicating a role of Axin in the regulation of growth induced by ERK pathway activation . Positive_regulation EPHB2 EGF 17474086 1772248 These results indicate that phosphorylation and *activation* of extracellular signal regulated protein kinase [ERK] , elevated levels of intracellular Ca ( 2+ ) and the transactivation of the receptor are essential for BzATP induced upregulation of Egr-1 . Positive_regulation EPHB2 EGF 17483331 1739075 Knockdown of Brk by stable expression of short hairpin RNA ( shRNA ) in T47D breast cancer cells decreases proliferation and blocks and heregulin *induced* activation of Rac GTPase , extracellular signal regulated kinase ( [ERK] ) 5 , and p38 mitogen activated protein kinase (MAPK) but not Akt , ERK1/2 , or c-Jun NH ( 2 ) -terminal kinase . Positive_regulation EPHB2 EGF 17540764 1767316 We examined this issue by quantifying the dynamics of [Erk] signaling *induced* by , basic fibroblast growth factor (bFGF) , and platelet derived growth factor ( PDGF ) in NIH-3T3 fibroblasts . Positive_regulation EPHB2 EGF 17563371 1763002 We previously documented that IQGAP1 binds ERK and MAPK kinase ( MEK ) and regulates *stimulated* MEK and [ERK] activity . Positive_regulation EPHB2 EGF 17724343 1789885 RKTG expression inhibits *stimulated* [ERK] and RSK phosphorylation , blocks NGF mediated PC12 cell differentiation , and antagonizes Ras- and Raf-1 stimulated Elk-1 transactivation . Positive_regulation EPHB2 EGF 17724343 1789899 In RKTG deleted mouse embryonic fibroblasts , *induced* [ERK] phosphorylation is enhanced . Positive_regulation EPHB2 EGF 18004277 1827225 Model analysis and experimental validation show that ( i ) ErbB2 overexpression , which occurs in approximately 25 % of all breast cancers , transforms transient EGF induced signaling into sustained signaling , ( ii ) HRG induced ERK activity is much more robust to the ERK cascade inhibitor U0126 than EGF induced ERK activity , and ( iii ) phosphoinositol-3 kinase is a major regulator of post-peak but not pre-peak *induced* [ERK] activity . Positive_regulation EPHB2 EGF 18004740 1894548 treatment of the cell clones *induced* strong activation of [ERK] similar to HGF treatment , but did not inhibit cell proliferation . Positive_regulation EPHB2 EGF 18033688 1860822 In addition , clonogenic survival assays revealed that matuzumab and cetuximab reduced the survival rate of H292 cells , in which they also inhibited the induced *activation* of Akt and [Erk] . Positive_regulation EPHB2 EGF 18381200 1907027 Suppression of protein l-isoaspartyl ( d-aspartyl ) methyltransferase results in hyperactivation of *stimulated* [MEK-ERK] signaling in cultured mammalian cells . Positive_regulation EPHB2 EGF 18400375 1925712 EGF plus EGFR inhibitor primed ovarian cancer cells display increased sensitivity to taxol induced cell death , resistant to *induced* cell migration and cell proliferation as well as [ERK] and PI3K/AKT activation . Positive_regulation EPHB2 EGF 18421299 1907835 Inhibition of SHP2 suppressed induced *activation* of the [Ras-ERK] and the phosphatidylinositol 3 kinase-Akt signaling pathways , abolished anchorage independent growth , induced epithelial cell morphology and led to reversion to a normal breast epithelial phenotype . Positive_regulation EPHB2 EGF 18509002 1918233 Inhibition of *stimulated* src and [ERK] phosphorylation , as well as reduction of migration properties of ARO cells was also observed . Positive_regulation EPHB2 EGF 18566245 1929588 The photochemically induced [ERK] phosphorylation was *enhanced* by stimulation to a level above that obtainable with epidermal growth factor alone . Positive_regulation EPHB2 EGF 18681747 1948298 Under normal conditions , *stimulates* a rapid but transient activation of [ERK] as the signal is rapidly shutdown , whereas under cancerous conditions , the ERK signal can not be shutdown and is sustained . Positive_regulation EPHB2 EGF 18692155 2020221 Only *activated* [ERK] signaling and up-regulated early gene expression , while DHT triggered the expression of classical AR-responsive genes with the exception of the EGF induced PSA transcript in A549 cells . Positive_regulation EPHB2 EGF 18724389 1984977 WWP1 depletion dramatically attenuates the *induced* [ERK] phosphorylation . Positive_regulation EPHB2 EGF 18762250 1975629 Additionally , EGFR undergoes MEK1 dependent [ERK] consensus site phosphorylation in *response* to or cytokines such as growth hormone (GH) and prolactin (PRL) . Positive_regulation EPHB2 EGF 19015044 2035054 The receptor *activates* [ERK] but not JNK Ras-dependently in basal conditions but ERK and JNK activation pathways are predominantly Ras independent during cardiomyocyte stretch . Positive_regulation EPHB2 EGF 19318229 2080244 ZD6474 and ZD1839 inhibited *induced* phosphorylation of EGFR , AKT and [ERK] , whereas VEGF induced phosphorylation of VEGFR2 was completely inhibited with 0.1 microM SU11248 . Positive_regulation EPHB2 EGF 19385051 2069283 also *induced* the phosphorylation of EGFR , [ERK] , and STAT-3 , and these effects were inhibited by the EGFR inhibitor , AG1478 . Positive_regulation EPHB2 EGF 19385051 2069299 Therefore , for the first time , we suggest that the JAK3 inhibitor , WHI-P131 , inhibits *induced* STAT-3 phosphorylation as well as [ERK] phosphorylation . Positive_regulation EPHB2 EGF 19457093 2101674 Inhibition of *induced* [ERK/MAP] kinase mediated astrocyte proliferation by mu opioids : integration of G protein and beta-arrestin 2-dependent pathways . Positive_regulation EPHB2 EGF 19457093 2101679 Long-term ( h ) treatment of primary astrocytes with [ d-ala ( 2 ) , mephe ( 4 ) , gly-ol ( 5 ) ] enkephalin or morphine , attenuated *induced* [ERK] phosphorylation and proliferation ( as measured by 5'-bromo-2'-deoxy-uridine labeling ) . Positive_regulation EPHB2 EGF 19457093 2101680 Unexpectedly , beta-arrestin-2 siRNA diminished both *induced* [ERK] activation and primary astrocyte proliferation suggesting that this adaptor protein plays a novel role in EGF signaling as well as in the opioid receptor phase of this pathway . Positive_regulation EPHB2 EGF 19481073 2102528 Other growth factors that *activate* [MAPK/ERK] signaling ( , PDGF , IGF ) did not induce Jag1 . Positive_regulation EPHB2 EGF 19501623 2128460 The present findings therefore suggest that receptor transactivation in astrocytes in the mature brain in vivo is an important process in response to alpha ( 2 ) -adrenoceptor stimulation and may *lead* to phosphorylation of [ERK] ( 1/2 ) both in astrocytes themselves and in adjacent neurons . Positive_regulation EPHB2 EGF 19509291 2108657 Consequently , [Erk] activation in *response* to stimulation is regulated by the expression of GAREM in COS-7 and HeLa cells , which occurs independent of the presence of other binding proteins , such as Gab1 and SOS , to the activated EGF receptor . Positive_regulation EPHB2 EGF 19559020 2117209 Brefelamide inhibited *induced* phosphorylation of [ERK] in a concentration dependent manner . Positive_regulation EPHB2 EGF 19625610 2142921 Especially , phosphorylation of caveolin-1 is attenuated by AG1478 , herbimycin A ( tyrosine kinase inhibitors ) , and pyrazolopyrimidine 2 ( PP2 , Src inhibitor ) and induced [ERK] *activation* was blocked by PP2 , methyl-beta-cyclodextrin ( MbetaCD ) , caveolin-1 small interfering RNA ( siRNA ) , LY-294002 [ phosphoinositol-3 kinase inhibitor ( PI3K ) ] , and Akt inhibitor . Positive_regulation EPHB2 EGF 19638615 2113145 These two cell lines also showed distinct patterns of *dependent* [ERK] phosphorylation and signaling : ERK activation and signaling were transient in HEK293 cells and sustained in RK13 cells , with the difference resulting from the lack of negative feedback from ERK to Sos ( Son of Sevenless ) in the latter . Positive_regulation EPHB2 EGF 19941816 2167667 *induced* [ERK] activation promotes CK2 mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin . Positive_regulation EPHB2 EGF 20230789 2237595 In this report , we show that serine282 residue of Nox activator 1 (NoxA1) is phosphorylated by [Erk] in *response* to resulting in desensitization of Nox1 activity . Positive_regulation EPHB2 EGF 20385709 2273602 Neutralizing antibody against alpha5beta1 integrin partially ( approximately 60 % ) blocked BK-induced ERK activation but did not affect induced [ERK] *activation* . Positive_regulation EPHB2 EGF 20407013 2262388 The atypical protein kinase Czeta (PKCzeta) was recently shown to mediate *induced* activation of extracellular signal regulated kinase ( [ERK] ) in head and neck squamous carcinoma ( HNSCC ) cells . Positive_regulation EPHB2 EGF 20407013 2262389 The importance of PKCzeta in *induced* [ERK] activation can also be shown in several HNSCC and breast carcinoma cell lines as well as in PKCzeta-deficient mouse embryonic fibroblasts . Positive_regulation EPHB2 EGF 20473309 2269505 MyD88 ( myeloid differentiation primary response gene 88 ) -independent activation of ERK by *increased* [p-ERK] and c-Myc and restored the multiple intestinal neoplasia ( Min ) phenotype in Apc ( min/+ ) /Myd88 ( -/- ) mice . Positive_regulation EPHB2 EGF 20493519 2270237 In the cytosol , induces transient and HRG *induces* sustained [ERK] activation . Positive_regulation EPHB2 EGF 20563247 2280059 Deletion of oncogenic KRAS not only resensitized tumor cells to EGFR inhibition but also promoted *induced* NRAS activation , [ERK] and AKT phosphorylation , and c-FOS transcription . Positive_regulation EPHB2 EGF 20563247 2280065 This caused an EGFR dependent increase in basal and *stimulated* [ERK] phosphorylation but failed to restore tumor cell sensitivity to EGFR inhibition . Positive_regulation EPHB2 EGF 20628053 2310207 Interestingly , siRNA mediated knockdown of paxillin expression in androgen dependent LnCAP cells as well as in androgen independent PC3 cells abrogates DHT- and/or *induced* [Erk] signaling . Positive_regulation EPHB2 EGF 20724475 2330213 *induced* activation of [ERK] has been extensively studied by both experimental and theoretical approaches . Positive_regulation EPHB2 EGF 20810616 2341744 We found that nanomolar concentrations of Sorafenib reduced the basal activity of ERK , *inhibited* cAMP dependent activation of B-Raf and [MEK/ERK] signaling , and caused a concentration dependent inhibition of cell proliferation induced by cAMP , , or the combination of the two agonists . Positive_regulation EPHB2 EGF 20946955 2364893 We find that GH and specifically *synergize* for activation of [ERK] in murine preadipocytes . Positive_regulation EPHB2 EGF 20946955 2364894 Furthermore , dephosphorylation of the scaffold protein , KSR , at a critical serine residue is also synergistically promoted by GH and EGF , suggesting that GH sensitizes these cells to *induced* [ERK] activation by augmenting the actions of KSR in facilitating MEK-ERK activation . Positive_regulation EPHB2 EGF 21073857 2413884 U0126 , a MEK inhibitor , inhibited *induced* increases in c-Fos , [p-ERK] , and TRPM6 levels . Positive_regulation EPHB2 EGF 21073857 2413886 In contrast , neither rapamycin nor LY-294002 inhibited *induced* increases in [p-ERK] and c-Fos levels . Positive_regulation EPHB2 EGF 21081118 2383044 *induces* CREB and [ERK] activation at the wall of the mouse lateral ventricles . Positive_regulation EPHB2 EGF 21258366 2387440 Abolishment of Arg 1175 methylation enhances *stimulated* [ERK] activation by reducing SHP1 recruitment to EGFR , resulting in augmented cell proliferation , migration and invasion of EGFR expressing cells . Positive_regulation EPHB2 EGF 21462327 2412827 Capsaicin suppressed EGF induced c-Jun and c-Fos nuclear translocation , and also abrogated the *induced* phosphorylation of EGF receptor (EGFR) , focal adhesion kinase ( FAK ) , protein kinase C ( PKC ) , phosphatidylinositol 3-Kinase (PI3K)/Akt , [extracellular regulated kinase (ERK)1/2] , and JNK1/2 , an upstream modulator of AP-1 . Positive_regulation EPHB2 EGF 21464950 2412922 In this study , human colorectal cancer cells treated with HDACi exhibited reduced EGFR expression , thereby disturbed *induced* [ERK] and Akt phosphorylation . Positive_regulation EPHB2 EGF 21622856 2446080 Blockage of Notch signaling with L-685,458 or Notch siRNA resulted in a decrease in *induced* phosphorylation of [ERK] . Positive_regulation EPHB2 EGF 21718029 2455941 Compounds 1 and 4 displayed strong cytotoxicity against three human tumor cell lines with GI50 values in the submicromolar range , whereas 2 showed subnanomolar activity as an inhibitor of EGFR-MAPK-AP1 mediated mitogenic signaling , causing inhibition of EGF mediated AP1 trans-activation and mediated [ERK] *activation* and slight inhibition of EGF mediated JNK activation . Positive_regulation EPHB2 EGF 21794976 2461938 Using specific chemical inhibitors , we demonstrated that EGF induced EMT is mediated by extracellular signal regulated kinase 1/2 ( ERK 1/2 ) signalling pathway and that resveratrol is able to repress *induced* [ERK] activation . Positive_regulation EPHB2 EGF 21795688 2476690 As a functional consequence of diminished PP1ß activity , we find that somatostatin- and substance P-induced but not induced [ERK] *activation* was aberrantly enhanced and prolonged . Positive_regulation EPHB2 EGF 21807900 2476860 Importantly , inhibition of PDE3 , and thus perturbation of the spatiotemporal regulation of PKA activity , dramatically increases the duration of *stimulated* nuclear [ERK] activity in a PKA dependent manner . Positive_regulation EPHB2 EGF 21829671 2468260 These simulations constitute a multi-dimensional exploration of how *dependent* EGFR endocytosis and [ERK] activation are dynamically affected by scaffolds KSR and MP1 , co-regulated by Cbl-CIN85 and Endophilin A1 . Positive_regulation EPHB2 EGF 21882253 2668082 Celecoxib inhibited basal and EGF stimulated proliferation , hypoxia related HIF-1a recruitment/stabilization as well as hypoxia- and dependent *activation* of [ERK] and PI3K . Positive_regulation EPHB2 EGF 21968647 2574473 Overexpression of PAQR10/PAQR11 stimulates basal and *induced* [ERK] phosphorylation and increases the expression of ERK target genes in a dose dependent manner . Positive_regulation EPHB2 EGF 21968647 2574480 Consistently , knockdown of PAQR10 and PAQR11 reduces *stimulated* [ERK] phosphorylation and Ras activation at the Golgi apparatus . Positive_regulation EPHB2 EGF 22033246 2527433 *induced* the phosphorylation of EGFR , smad3 , [ERK] , and JNK , and MMP-9 expression was decreased by the EGFR inhibitor , AG1478 . Positive_regulation EPHB2 EGF 22033920 2516785 Finally , we demonstrated that *induced* activation of [ERK] and interaction between PML and phosphorylated ERK resulting in a decrease in PML protein levels . Positive_regulation EPHB2 EGF 22069319 2534157 Conversely , IFN-? caused a significant decrease in *stimulated* phosphorylation of specific EGFr tyrosine residues and activation of [ERK] but not Akt-1 . Positive_regulation EPHB2 EGF 22070748 2517026 Au-NPs were found to decrease *dependent* Akt and [Erk] phosphorylation as well as inhibit Akt activity . Positive_regulation EPHB2 EGF 22198386 2575033 In addition to strong *activation* of [ERK] by , and AKT by serum , early transcription remarkably differed : while EGF induced early growth response-1 (EGR1) , and this was required for migration , serum induced c-Fos and FosB to enhance proliferation . Positive_regulation EPHB2 EGF 22245064 2559447 Dual specificity phosphatases 10 and 16 are positive regulators of *stimulated* [ERK] activity : indirect regulation of ERK signals by JNK/p38 selective MAPK phosphatases . Positive_regulation EPHB2 EGF 22245064 2559448 We have explored the possible role of dual specificity phosphatases ( DUSPs ) on acute *mediated* [ERK] signalling using high content imaging and a delayed MEK inhibition protocol to distinguish direct and indirect effects of the phosphatases on ERK activity . Positive_regulation EPHB2 EGF 22245064 2559449 Nevertheless , siRNAs against two p38/JNK MKPs ( DUSPs 10 and 16 ) inhibited acute *stimulated* [ERK] activation . Positive_regulation EPHB2 EGF 22245064 2559450 Inhibition of *stimulated* [ERK] activity by these siRNAs was reversed by pharmacological inhibition of p38 MAPK and single cell analysis revealed that the siRNAs did not influence the nuclear-cytoplasmic distribution of ppERK1/2 . Positive_regulation EPHB2 EGF 22245064 2559451 A simplified mathematical model of this scenario accurately predicted the experimental data , supporting the conclusion that the major mechanism by which MKPs influence acute *stimulated* [ERK] responses is the negative regulation of p38 , resulting in the positive regulation of ERK phosphorylation and activity . Positive_regulation EPHB2 EGF 22251451 2668242 Moreover , GPER was required for epidermal growth factor receptor (EGFR) and [ERK] *activation* by as ascertained by using MIBE and performing gene silencing experiments . Positive_regulation EPHB2 EGF 22266356 2559784 An examination of the effect of sialylation on epidermal growth factor receptor (EGFR) activity and downstream signaling , which are highly correlated with cell proliferation , showed that the loss of ST6Gal-I augmented *induced* EGFR phosphorylation and activation of extracellular signal regulated kinase ( [ERK] ) in colon cancer cells . Positive_regulation EPHB2 EGF 22503980 2589500 Both and PGE ( 2 ) *increased* the expression of [ERK] and Akt , but while the effect of EGF was inhibited by ErbB2 directed siRNA , this did not affect the PGE ( 2 ) -induced upregulation of ERK and Akt . Positive_regulation EPHB2 EGF 22509540 2522555 *increased* the phosphorylation levels of EGFR , AKT and [ERK] , and increased the expression of MMP-2 . Positive_regulation EPHB2 EGF 22514047 2613346 Reduction in nucleobindin-2 expression inhibited *stimulated* MAPK kinase ( S217/S221 ) and [Erk] phosphorylation ( T202/Y204 ) . Positive_regulation EPHB2 EGF 22514047 2613351 Taken together , these data indicate that nucleobindin-2 regulates *stimulated* MAPK [kinase/Erk] signaling , cell proliferation , and adipocyte differentiation . Positive_regulation EPHB2 EGF 22538822 2596033 These studies therefore offer insights into ( i ) allosteric inhibition of KGA by BPTES , revealing the dynamic nature of KGA 's active and inhibitory sites , and ( ii ) cross-talk and regulation of KGA activities by *mediated* [Raf-Mek-Erk] signaling . Positive_regulation EPHB2 EGF 22683533 2638532 CTX III suppressed EGF induced nuclear factor-kappaB ( NF-?B ) nuclear translocation and also abrogated the *induced* phosphorylation of EGFR , phosphatidylinositol 3-kinase (PI3K)/Akt , and [extracellular regulated kinase (ERK)1/2] . Positive_regulation EPHB2 EGF 22701712 2615841 GEP100/Arf6 is required for *induced* [ERK/Rac1] signaling and cell migration in human hepatoma HepG2 cells . Positive_regulation EPHB2 EGF 22701712 2615849 also *increased* [ERK] and Rac1 activity . Positive_regulation EPHB2 EGF 22701712 2615856 Ectopic expression GEP100 siRNA , GEP100-?PH , or Arf6-T27N suppressed *induced* [ERK] and Rac1 activity . Positive_regulation EPHB2 EGF 22745828 2621988 *induced* phosphorylation of EGFR , Akt and [ERK] was markedly blunted in SCD5 expressing cells . Positive_regulation EPHB2 EGF 22828136 2687265 The cell proliferation rate , anchorage independent growth , *stimulated* [ERK] phosphorylation and EGF induced nuclear accumulation of ß-catenin were inhibited by PAQR3 overexpression and enhanced by PAQR3 knockdown in SW-480 colorectal cancer cells . Positive_regulation EPHB2 EGF 23007402 2702233 *activates* [ERK/p90RSK] and Rho/Rho kinase signaling in A431 and DiFi colon cancer cells , leading to phosphorylation of filamin A (FLNa) and inactivation of the a5ß1 integrin receptor . Positive_regulation EPHB2 EGF 23102728 2729184 In the parental PC-9 cells , labeled as PC-9/wt , gefitinib completely inhibited *induced* phosphorylation of EGFR , AKT and [ERK] . Positive_regulation EPHB2 EGF 23102728 2729188 Gefitinib inhibited EGFR phosphorylation , but was unable to block *induced* phosphorylation of [ERK] in resistant cells , labeled as PC-9/gef cells , including PC-9/gefB4 , PC-9/gefE3 , and PC-9/gefE7 subclones . Positive_regulation EPHB2 EGF 23129763 2707140 As a consequence , *induced* activation of [Erk] and Akt as well as cell proliferation were enhanced in PACSIN2 depleted cells . Positive_regulation EPHB2 EGF 23168795 2745360 All three sites were central for *induced* [ERK-activity] and Cdk2 expression . Positive_regulation EPHB2 EGF 23180942 2704356 at 10 ng/mL *induced* the phosphorylation of EGFR , AKT and [ERK] in both cell lines with similar kinetics . Positive_regulation EPHB2 EGF 23180942 2704360 Our data suggest basal AKT phosphorylation and the degree of induced *activation* of AKT and [ERK] as molecular determinants of erlotinib efficiency in PC cells . Positive_regulation EPHB2 EGF 23300058 2758161 In four of 19 BC samples but in none of the NC specimens , SCNP assay identified epithelial cancer cells with a quantifiable increase in *induced* p-AKT and [p-ERK] levels . Positive_regulation EPHB2 EGF 23482085 2771837 The in vitro results showed that *induces* the upregulation of KCa3.1 and [P-ERK] in HUVECs and that this upregulation is suppressed by PD98059 . Positive_regulation EPHB2 EGF 23747719 2807300 *increased* Arf6 activity , [ERK] phosphorylation , and uPAR expression in a time dependent manner . Positive_regulation EPHB2 EGF 23747719 2807303 GEP100 siRNA or Arf6 siRNA suppressed *induced* [ERK] activity and uPAR expression . Positive_regulation EPHB2 EGF 23911909 2840519 Likewise , [ERK] phosphorylation was markedly enhanced in PAF stimulated VSMCs , and this was *attenuated* by WEB2086 , but not by receptor inhibitor , demonstrating the specificity of PAF receptor (PAFR) in PAF induced ERK phosphorylation . Positive_regulation EPHB2 EGF 24043306 2857283 We conclude that Rac1 T108 is phosphorylated by [ERK] in *response* to , which plays an important role in regulating Rac1 . Positive_regulation EPHB2 EGF 24188029 2921093 Here , we show that HB-EGF *induced* activation by Y1068 phosphorylation , [Mapk/Erk] pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation EPHB2 EGF 24198336 2868564 NSCs from GD3S-KO mice showed decreased self-renewal ability compared with those from the wild-type animals , and that decreased ability was accompanied by reduced expression of EGF receptor (EGFR) and an increased degradation rate of EGFR and *induced* [ERK] signaling . Positive_regulation EPHB2 EGF 24456610 2918201 This is associated with inhibition of basal and *stimulated* Akt and [Erk] signals and enhancement of total and phosphorylated levels of p53 . Positive_regulation EPHB2 EGF 24484548 2942561 Dihydrotestosterone potentiates *induced* [ERK] activation by inducing SRC in fetal lung fibroblasts . Positive_regulation EPHB2 EGF 24534906 2918975 Infecting the cells with Ad-PKG II and stimulating the kinase with 8-pCPT-cGMP efficiently inhibited the phosphorylation of the EGFR and [MAPK/ERK] *induced* by , TGF-a , BTC and EPR . Positive_regulation EPHB2 EGF 25197261 2958067 We show SphK1 overexpression increased *induced* [EGFR/ERK] and AKT activity , increased matrix metalloproteinase (MMP)-2/9 mRNA and reduced E-cadherin . Positive_regulation EPHB2 EGF 25258648 2958936 In OVCAR-3 cells , *activated* [Erk] and Akt , but an Erk inhibitor had no impact on cellular viability . Positive_regulation EPHB2 EGF 25258648 2958940 Although *activated* [Erk] in SKOV-3 cells , the Akt activation was very weak as compared to OVCAR-3 cells . Positive_regulation EPHB2 EGF 7588209 329830 Dexamethasone does not inhibit *induction* of tyrosyl phosphorylation of [ERK] proteins by or phorbol myristate acetate , nor does it block induction of tyrosyl phosphorylation of Stat3/APRF by leukemia inhibitory factor or interleukin-6 , or induction of JAK2 by leukemia inhibitory factor or interferon-gamma . Positive_regulation EPHB2 EGF 7860643 295251 CGP41251 completely abolishes the increased [ERK] activity produced by PMA , but the effect of in this regard is *potentiated* . Positive_regulation EPHB2 EGF 7929360 274503 On the other hand , *causes* a prolonged activation of Raf-1 kinase and [ERK] activity and a smaller , more transient activation of JNK , whereas the phorbol ester phorbol 12-myristate 13-acetate causes a small stimulation of Raf-1 kinase and a pronounced stimulation of ERK activity . Positive_regulation EPHB2 EGF 8524249 335113 In contrast to results with Abl , [Erk] *activation* by was strongly inhibited only by Grb2 mutants ; Positive_regulation EPHB2 EGF 8524249 335115 This finding suggests that Grb2 is the only adapter involved in the *activation* of [Erk] by . Positive_regulation EPHB2 EGF 8626525 360400 Although stimulation of the mutant EGF receptor *activates* [ERK] and phosphorylation of both Shc and SOS , it fails to directly associate with either Shc or Grb2 . Positive_regulation EPHB2 EGF 8662831 367389 also *stimulates* [RAS/ERK] but in a transient manner . Positive_regulation EPHB2 EGF 8662831 367394 Importantly , IL-6 does not enhance [ERK] phosphorylation in the *presence* of either NGF or . Positive_regulation EPHB2 EGF 8885243 391078 *induced* both [ERK] and SAPK activity in JEG-3 cells . Positive_regulation EPHB2 EGF 9142901 428577 In experiments using in-gel kinase assays , MK-678 also inhibited *stimulated* [ERK] activity via a pertussis toxin sensitive pathway , and this effect resulted in inhibition of Elk-1 transcriptional activity . Positive_regulation EPHB2 EGF 9165004 432186 Similarly , 10 microM forskolin had no effect on IGF-I- or *induced* [ERK] activity in cells treated with growth factor for 30 min . Positive_regulation EPHB2 EGF 9165004 432192 These data demonstrate that in MCF-7 breast cancer cells , cAMP has no effect on IGF-I- or *induced* [ERK] activity , but it inhibits growth factor induced transcription . Positive_regulation EPHB2 EGF 9182816 436327 Differential *stimulation* of [ERK] and JNK activities by ultraviolet B irradiation and in human keratinocytes . Positive_regulation EPHB2 EGF 9305638 454076 Kinase-inactive MEKK1 , but not MEKK2 , 3 or 4 , strongly inhibited *stimulated* [ERK] activity . Positive_regulation EPHB2 EGF 9407138 470900 In contrast , specific inhibition of the RAF/ERK pathway by PD98059 ( MEK1 inhibitor ) completely blocked [ERK] *activation* by and basal cell growth but not EGF stimulated growth , thereby dissociating the growth promoting roles of each pathway . Positive_regulation EPHB2 EGF 9453557 484229 These results suggest a mechanism involving Ras and betagamma subunits of Gi/o proteins in opioid agonist activation of ERK1 and ERK2 , as well as opioid modulation of *induced* [ERK] activity . Positive_regulation EPHB2 EGF 9564040 500722 In PKC depleted cells , receptor-specific tyrosine kinase inhibitors *blocked* Ang II-dependent EGF receptor and Cbl tyrosine phosphorylation , and [ERK] activation . Positive_regulation EPHB2 EGF 9733710 530749 Nerve growth factor (NGF) induces sustained activation of classical MAP kinase ( MAPK , also known as ERK ) and neuronal differentiation in PC12 cells , whereas *induces* transient activation of [ERK/MAPK] and stimulates proliferation of the cells . Positive_regulation EPHB2 EGF 9765228 537917 [ERK] phosphorylation was also *induced* by ( 100 ng/ml ) . Positive_regulation EPHB2 EGF 9933031 589201 On the other hand , an obligatory tyrosine phosphorylation step for activation of ERK was indicated by the use of protein tyrosine kinase inhibitors , which profoundly inhibited the *activation* of [ERK] by , Ang II , and PMA . Positive_regulation EPHB2 EGF 9988714 596885 As seen with exogenous AA , *increased* [ERK] tyrosine phosphorylation to a significantly greater extent in F87V BM-3 cells than in vector transfected cells . Positive_regulation EPHB2 EGFL6 21531721 2444595 Inhibition of ERK impaired *induced* [ERK] activation and endothelial cell migration . Positive_regulation EPHB2 EGFR 10801894 708027 In contrast , H ( 2 ) O ( 2 ) -induced [ERK] activation is *dependent* on activation , which then leads to downstream Raf-1 and MEK-1 activation . Positive_regulation EPHB2 EGFR 11290747 819844 dependent [ERK] *activation* by G protein coupled receptors : a co-culture system for identifying intermediates upstream and downstream of heparin binding EGF shedding . Positive_regulation EPHB2 EGFR 11319218 827099 We previously have demonstrated that increased M-calpain activity downstream of mediated [ERK] *activation* is necessary for epidermal growth factor (EGF) induced motility . Positive_regulation EPHB2 EGFR 11319218 827129 These data strongly suggest that EGF induced calpain activity can be enhanced near sites of membrane-proximal *mediated* [ERK] signaling , providing insights about how calpain activity might be regulated and targeted to enhance its effects on adhesion related substrates . Positive_regulation EPHB2 EGFR 11457825 850810 mu-Opioid receptor mediated [ERK] activation *involves* calmodulin dependent transactivation . Positive_regulation EPHB2 EGFR 11502566 847678 Addition of EGFR tyrosine kinase inhibitors ( e.g. , tyrphostin AG-1478 ) abrogated bombesin induced extracellular signal regulated kinase ( ERK ) activation in Rat-1 cells but not in Swiss 3T3 cells , indicating the importance of cell context in determining the *role* of in [ERK] activation . Positive_regulation EPHB2 EGFR 11592962 883134 gene deficiency *blocked* TPA induced [ERK] activity and AP-1 binding activity . Positive_regulation EPHB2 EGFR 11826403 909389 The inhibitor ( AG1478 ) significantly *inhibited* ( approximately 81 % ) the activation of [ERK] by DCA . Positive_regulation EPHB2 EGFR 11889128 937405 The stimulatory effect of NE on [ERK] is abrogated in the *presence* of anti-EGF neutralizing antibodies , tyrosine kinase inhibitor ( AG1478 ) , and ERK kinase inhibitor ( PD98059 ) , as well as abolished in both EGFR desensitized and endocytosis arrested fibroblasts . Positive_regulation EPHB2 EGFR 11988485 936296 rPMT stimulates the ERK cascade via transactivation in cardiac fibroblasts , but EGF receptor transactivation *plays* no role in [ERK] activation in cardiomyocytes . Positive_regulation EPHB2 EGFR 12402303 1009466 Submicromolar doses of alkyl-lysophospholipids induce rapid internalization , but not activation , of and concomitant [MAPK/ERK] *activation* in A431 cells . Positive_regulation EPHB2 EGFR 12402303 1009494 Since ALPs readily intercalate into the plasma membrane , our data suggest that they induce subtle changes in the lipid microenvironment of the EGFR , resulting in clustering and internalization of the and concomitant [MAPK/ERK] *activation* . Positive_regulation EPHB2 EGFR 12421825 1036401 Expression of dominant negative mini-genes for Galpha ( q ) and Galpha ( i ) blocked E2-induced , *dependent* [ERK] activation , and Gbetagamma also contributed . Positive_regulation EPHB2 EGFR 12447997 1018229 Furthermore , treatment with LPA alone induces the rapid ( maximal signal within 2 min ) tyrosine phosphorylation of , and subsequent ( maximal signal after 5 min ) *activation* of [ERK] , suggesting that EGFR activation precedes ERK phosphorylation and may constitute a required component for signal relay from the LPA receptor to ERK . Positive_regulation EPHB2 EGFR 12447997 1018230 Accordingly , we show that inhibition of kinase activity *attenuates* the LPA regulated [ERK] activation . Positive_regulation EPHB2 EGFR 12447997 1018233 In addition , we find that the LPA regulated tyrosine phosphorylation of and *activation* of [ERK] are attenuated by batimastat , a generic inhibitor of matrix metalloproteinases (MMP) . Positive_regulation EPHB2 EGFR 12534349 1079138 [ERK] activation by IBOP , a TX analogue , was *dependent* on in TP alpha- or TP beta transfected cells and in human aortic smooth muscle cells ( hASMCs ) , since AG1478 , a selective inhibitor of tyrosine phosphorylation of the EGFR , strongly blocked ERK and EGFR phosphorylation . Positive_regulation EPHB2 EGFR 12719447 1093399 In contrast , ET-induced [ERK] activation and c-fos gene expression were predominantly *regulated* by . Positive_regulation EPHB2 EGFR 12833145 1105811 RALT deltaEBR , a mutant unable to bind to ErbB RTKs , did not inhibit *dependent* activation of [ERK] and AKT , consistent with RALT exerting its suppressive activity towards these pathways at a receptor-proximal level . Positive_regulation EPHB2 EGFR 12891702 1117751 Also , gastrin dependent COX-2 expression did not require PKC activity , *activation* of [ERK] , or transactivation of . Positive_regulation EPHB2 EGFR 12966092 1164376 phosphorylation , in turn , *led* to Ras dependent [Erk] activation . Positive_regulation EPHB2 EGFR 14593113 1187319 Inhibition of the with function blocking monoclonal antibodies also specifically *blocked* IGF-I induced [ERK] activation . Positive_regulation EPHB2 EGFR 14645669 1173051 The kappa opioid agonist ( 5alpha,7alpha,8beta ) - ( - ) -N-methyl-N- ( 7- ( 1-pyrrolidinyl ) -1-oxaspiro ( 4,5 ) dec-8-yl ) benzeneacetamide ( U69,593 ) induced Tyr and Ser phosphorylation of and *activation* of [ERK] . Positive_regulation EPHB2 EGFR 14657000 1202026 We investigated this crosstalk under different conditions and found that both Akt and [ERK] activation induced by S1P , but not lysophosphatidic acid (LPA) , in HEY ovarian cancer cells *required* PDGFR but not or insulin-like growth factor-I receptor ( IGFR ) . Positive_regulation EPHB2 EGFR 15177934 1255118 The NT-induced stimulation of [EGFR/ERK/Akt] phosphorylation and DNA synthesis was *inhibited* by kinase inhibitors ( AG1478 , PD153035 ) , metallo-endopeptidase inhibitor phosphoramidon and by heparin , but not by neutralizing anti-EGF antibody . Positive_regulation EPHB2 EGFR 15254267 1290059 Basal ErbB tyrosine phosphorylation and [ERK] phosphorylation were *inhibited* by two different receptor tyrosine kinase inhibitors , by the ErbB1-specific neutralizing monoclonal antibody 225 IgG , by two different metalloproteinase inhibitors , and by neutralizing antibodies against amphiregulin (AR) . Positive_regulation EPHB2 EGFR 15262961 1290151 Whereas [ERK] activation *results* from the upstream activation of , JNK activation is chiefly EGFR independent . Positive_regulation EPHB2 EGFR 15381832 1298783 The gastric mucosal phospholipid secretory responses to isoproterenol , furthermore , were inhibited by PP2 , a selective inhibitor of tyrosine kinase Src responsible for ligand independent phosphorylation , but not by [ERK] *inhibitor* , PD98059 . Positive_regulation EPHB2 EGFR 15471881 1342459 The presence of AG1478 , an epidermal growth factor (EGF) receptor ( EGFR ) kinase inhibitor , had no effect on ERK or Ras activation , indicating that kinase activity is not *involved* in [ERK] activation by UVA . Positive_regulation EPHB2 EGFR 15504454 1327471 [ERK] activation by arsenite was fully *dependent* on the catalytic activity of the and partially dependent on Src-family kinase activity . Positive_regulation EPHB2 EGFR 15542601 1360694 In this study , we analyzed the *role* of the in RSV activation of [ERK] . Positive_regulation EPHB2 EGFR 15542601 1360696 Activation of *results* in increased [ERK] activity , contributing to both the inflammatory response ( IL-8 release ) and prolonging the survival of RSV infected cells . Positive_regulation EPHB2 EGFR 15572377 1368345 Here we applied a combination of computational modeling and quantitative experimental studies of the dynamic interactions between and HER2 and their downstream *activation* of [ERK] to understand this complex signaling system . Positive_regulation EPHB2 EGFR 15677486 1369861 We found that the presence of polyQ peptides indeed abolished dEAAT1 upregulation by constitutively active EGFR and potently inhibited mediated [ERK] *activation* in fly glial cells . Positive_regulation EPHB2 EGFR 15878157 1411326 TPA induced activation of [ERK] and PKCdelta was *dependent* on the expression of although the intrinsic kinase activity of EGFR was not required . Positive_regulation EPHB2 EGFR 15982313 1424725 ( iii ) the activation of is *essential* for the subsequent activation of [ERK] and Akt ; Positive_regulation EPHB2 EGFR 16125295 1461124 The [ERK] activation and cell death induced by H2O2 were not *dependent* on the phosphorylation of . Positive_regulation EPHB2 EGFR 16226010 1531991 In the COS-7 cell signalling network high levels of cAMP produced , for example , by co-stimulation of beta2-adrenergic receptor (beta2-AR) and bradykinin B2 receptor ( BKR ) may affect *mediated* activation of extracellular signal stimulated kinase ( [ERK] ) . Positive_regulation EPHB2 EGFR 16316986 1511358 Consistent with this , *mediated* JNK or [ERK] activation was significantly suppressed in Fut8-/- cells . Positive_regulation EPHB2 EGFR 16341693 1553841 *dependent* [ERK] activation triggers hydrogen peroxide induced apoptosis in OK renal epithelial cells . Positive_regulation EPHB2 EGFR 16341693 1553843 Taken together , our findings suggest that the [ERK] activation *mediated* by plays an active role in inducing H2O2 induced apoptosis of OK cells and functions upstream of mitochondria dependent pathway to initiate the apoptotic signal . Positive_regulation EPHB2 EGFR 16630586 1562891 *induced* [Erk] phosphorylation in the suprachiasmatic nucleus . Positive_regulation EPHB2 EGFR 16737974 1585291 [ERK] phosphorylation was *attenuated* by 1 ) neutralizing EGFR antibodies and the kinase inhibitor , AG1478 , 2 ) neutralizing HB-EGF , but not amphiregulin , antibodies , heparin , or CM197 , and 3 ) pharmacological inhibitors of matrix degrading metalloproteinases or TACE small interfering RNA . Positive_regulation EPHB2 EGFR 16788692 1599451 STAT3 attenuates mediated [ERK] *activation* and cell survival during oxidant stress in mouse proximal tubular cells . Positive_regulation EPHB2 EGFR 16860436 1632240 Inhibitors of ( AG 1478 ) , Ras and Raf , as well as antioxidants *inhibited* activation of [ERK] and Akt , while the Src inhibitor PP2 had no effect . Positive_regulation EPHB2 EGFR 16973240 1646998 The effect of leptin on ERK and Na ( + ) , K ( + ) -ATPase was abolished by catalase , specific inhibitors of , AG1478 and PD158780 , as well as by [ERK] *inhibitor* , PD98059 , and was mimicked by both exogenous H ( 2 ) O ( 2 ) and EGF . Positive_regulation EPHB2 EGFR 17149366 1661616 Inhibition of activation by AG1478 or the MMP inhibitor , GM6001 , *reduced* phosphorylation of insulin induced [ERK] in the presence of insulin and delayed wound closure . Positive_regulation EPHB2 EGFR 17226785 1696267 However , ligand independent phosphorylation of the EGF receptor (EGFR) by removal of cholesterol precedes Ras activation , and the kinase inhibitor AG1478 *blocks* [Erk] phosphorylation , supporting occurrence of the signaling sequence EGFR-Ras-MEK-Erk . Positive_regulation EPHB2 EGFR 17374561 1748330 WNT3a induced [ERK] pathway activations were *blocked* by AG1478 , the inhibitor , and EGFR siRNA . Positive_regulation EPHB2 EGFR 17374561 1748334 These results indicate that WNT3a stimulates proliferation and motility of NIH3T3 fibroblasts via *mediated* [ERK] pathway activation . Positive_regulation EPHB2 EGFR 17686966 1805685 Ciglitazone rapidly activates extracellular signal regulated kinase ( Erk ) MAPK , an event requiring c-Src kinase dependent epidermal growth factor receptor (EGFR) transactivation , whereas troglitazone only weakly activates [Erk] and does not *induce* transactivation ; Positive_regulation EPHB2 EGFR 17934341 1813472 PD153035 , an EGFR inhibitor , as well as alpha-NF significantly reduced ERK phosphorylation , suggesting that [ERK] activation by TCDD was *mediated* by both and AhR . Positive_regulation EPHB2 EGFR 18175225 1671215 We show that after CXCR4 activation , becomes tyrosine phosphorylated , and the kinase activity of this receptor , together with the activation of MMPs , Src , and PI3-Kinase , is *required* for CXCR4 mediated [ERK] activation . Positive_regulation EPHB2 EGFR 18360054 1887778 Phenylephrine induced protein synthesis , phosphorylation of , and *activation* of [ERK] in neonatal rat cardiomyocytes were all inhibited by atorvastatin . Positive_regulation EPHB2 EGFR 18421078 1938453 *stimulated* [ERK] causing its biphasic translocation to the nucleus . Positive_regulation EPHB2 EGFR 18719212 1955800 Treatment of gingival fibroblasts with EMD resulted in tyrosine phosphorylation of the EGFR , as assessed by immunoblotting and ELISA , while EMD induced [ERK] activation and thymidine incorporation were markedly *inhibited* ( approximately 40-50 % ) by a specific tyrosine kinase inhibitor . Positive_regulation EPHB2 EGFR 18838825 1976810 [ERK] signaling , which is classically *activated* by agonist stimulation of the , can be activated by a number of GPCRs in a beta-arrestin dependent manner . Positive_regulation EPHB2 EGFR 19015044 2035055 Under basal conditions , *activated* [ERK] in a classical Ras dependent manner . Positive_regulation EPHB2 EGFR 19015044 2035062 Upon stretch , transactivation *activated* [ERK] through both Ras dependent and Ras independent pathways . Positive_regulation EPHB2 EGFR 19190345 2038992 Here , we provide evidence that integration of the HH/GLI and epidermal growth factor receptor (EGFR) pathway synergistically induces oncogenic transformation , which depends on *mediated* activation of the [RAS/RAF/MEK/ERK] but not of the PI3K/AKT pathway . Positive_regulation EPHB2 EGFR 19385051 2069284 EGF also induced the phosphorylation of EGFR , [ERK] , and STAT-3 , and these effects were *inhibited* by the inhibitor , AG1478 . Positive_regulation EPHB2 EGFR 19559020 2117207 A reduction of is *involved* in brefelamide induced inhibition of phosphorylation of [ERK] in human astrocytoma cells . Positive_regulation EPHB2 EGFR 19850060 2184230 It is therefore important that a approximately 10-fold increase in potency occurred in the presence of the glutamate precursor glutamine , when [ERK] ( 1/2 ) phosphorylation became inhibitable by NMDA or non-NMDA antagonists and *dependent* upon transactivation . Positive_regulation EPHB2 EGFR 19878579 2160848 We found that HER3 signaling makes the strongest contribution to Akt activation and that , stimulation of either or HER3 *leads* to significant [Erk] activation . Positive_regulation EPHB2 EGFR 20228252 2281589 Furthermore , robust [ERK] *activation* by the ( a beta-arrestin 2 independent pathway ) had no effect on iNOS derived NO production . Positive_regulation EPHB2 EGFR 20458382 2275683 By using a `` non binding '' reporter of ligand shedding , we found that transactivation triggers a positive feedback loop from ERK back to the EGFR such that ligand shedding drives *stimulated* [ERK] that in turn drives further ligand shedding . Positive_regulation EPHB2 EGFR 20563247 2280066 This caused an *dependent* increase in basal and EGF stimulated [ERK] phosphorylation but failed to restore tumor cell sensitivity to EGFR inhibition . Positive_regulation EPHB2 EGFR 20628053 2310208 Furthermore , *induced* [Erk] activation requires Src mediated phosphorylation of paxillin on tyrosines 31/118 . Positive_regulation EPHB2 EGFR 20639215 2322040 We found that phosphorylation of this receptor contributed to Ras and [ERK] activation and that inhibition of ERK , PKC , and *blocked* the mitogenic response induced by sPLA ( 2 ) -IIA . Positive_regulation EPHB2 EGFR 20660715 2311037 Specific inhibition of EGFR and TRPV1 indicated that capsaicin induced [ERK] activation in A431 cells was *dependent* on , but not TRPV1 . Positive_regulation EPHB2 EGFR 20956971 2389470 The results raise the novel idea that the may *activate* [Raf-MEK-ERK] signaling in response to the binding of HA to CD44 . Positive_regulation EPHB2 EGFR 21075094 2371448 Exposure of A549 cells to B-2 caused inhibition of *dependent* [ERK-MAPK] activation . Positive_regulation EPHB2 EGFR 21212278 2408308 Surprisingly , TNF-a induced [ERK] and RhoA stimulation in tubular cells were *prevented* by inhibition or silencing . Positive_regulation EPHB2 EGFR 21258366 2387439 Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates mediated [ERK] *activation* . Positive_regulation EPHB2 EGFR 21258366 2387442 Therefore , we propose a model in which the regulatory crosstalk between PRMT5 mediated Arg 1175 methylation and EGF induced Tyr 1173 phosphorylation attenuates mediated [ERK] *activation* . Positive_regulation EPHB2 EGFR 21412767 2521372 EGF stimulated IL-8 production , phosphorylation of Akt and [Erk] , and cell proliferation and movement could be *inhibited* by inhibitor ( Erlotinib ) , PI3K inhibitor ( GDC-0941 BEZ-235 and SHBM1009 ) , and ERK1/2 inhibitor ( PD98059 ) . Positive_regulation EPHB2 EGFR 21462327 2412841 Capsaicin inhibited the EGF induced invasion and migration of human fibrosarcoma cells via *dependent* FAK/Akt , [PKC/Raf/ERK] , p38 mitogen activated protein kinase (MAPK) , and AP-1 signaling , leading to the down-regulation of MMP-9 expression . Positive_regulation EPHB2 EGFR 21622856 2446086 The [ERK] phosphorylation induced by exogenous NICD was *inhibited* by treatment with an Ab that antagonizes EGFR activity as well as by inhibitors of and ERK , implying that Notch signaling induces MUC5AC expression by activating the EGFR pathway . Positive_regulation EPHB2 EGFR 21760527 2456245 We have in the current study compared the effects of Nimotuzumab and Cetuximab on binding of EGF as well as on inhibition of constitutive dimerization and downstream *activation* of [Erk] . Positive_regulation EPHB2 EGFR 21762757 2461847 The *induced* [ERK] phosphorylation and ROS mediated NF?B activation were involved in the cytokine and angiogenic factor release . Positive_regulation EPHB2 EGFR 21954875 2546911 The inhibitor , AG1478 , *attenuated* [ERK] ( extracellular-signal regulated kinase ) activation and partially decreased cell survival . Positive_regulation EPHB2 EGFR 22095949 2548318 Using a murine model with EGFR-deficient proximal tubules , we demonstrate that upstream activation of *dependent* [ERK] signaling is critical for mediating sustained TGFß expression in renal fibrosis . Positive_regulation EPHB2 EGFR 22542783 2602900 Globoside promotes *activation* of [ERK] by interaction with the . Positive_regulation EPHB2 EGFR 22542783 2602901 Taken together , Gb4 promotes activation of *induced* [ERK] signaling through direct interaction with EGFR . Positive_regulation EPHB2 EGFR 22606262 2603698 These data suggest that targeting of Shoc2 to late endosomes may facilitate *induced* [ERK] activation under physiological conditions of cell stimulation by EGF , and therefore , may be involved in the spatiotemporal regulation of signaling through the RAS-RAF module . Positive_regulation EPHB2 EGFR 22675459 2611403 tyrosine kinase inhibitors *block* LPS stimulation of mitogen activated protein kinase [ERK] , suggesting an important role of the MAPK/ERK pathway in EGFR mediated COX-2 expression . Positive_regulation EPHB2 EGFR 22718763 2638933 Here , we demonstrate that nonmuscle myosin II ( NM II ) is required for the internalization of the EGFR and to trigger the dependent *activation* of [ERK] and AKT . Positive_regulation EPHB2 EGFR 22718763 2638941 Loss ( siRNA ) or inhibition ( 25 µm blebbistatin ) of NM II attenuates the internalization of the EGFR and impairs *dependent* activation of [ERK] and AKT . Positive_regulation EPHB2 EGFR 22984397 2674184 We showed that both activations at PM and EN *activated* [ERK] to a similar level , but differentially stimulated transcriptional factors c-jun and c-fos . Positive_regulation EPHB2 EGFR 23620784 2775059 Propagation of human prostate cancer stem-like cells occurs through mediated [ERK] *activation* . Positive_regulation EPHB2 EGFR 23811940 2838814 Targeting receptors shifts their partners and *triggers* persistent [ERK] signaling through a novel ERBB/EFNB1 complex . Positive_regulation EPHB2 EGFR 24021351 2856988 The inhibitor also *inhibited* the B [ a ] PDE induced [MEK/ERK] and Akt signaling pathways and subsequently , suppressed COX-2 expression and promoter activity , in addition to suppressing the transactivation of AP-1 and NF-?B . Positive_regulation EPHB2 EGFR 24486412 2923593 Blocking the TGF-a/EGFR pathway by gefitinib , a specific inhibitor , *reduced* the activation of STAT ( signal transducer and activator of transcription ) 3 , AKT and [ERK] ( extracellular signal regulated kinase ) , and synergized with sorafenib to inhibit proliferation and induce apoptosis of hypoxic HCC cells . Positive_regulation EPHB2 EGFR 24978309 2952568 We also assessed the involvement of *dependent* [ERK] and NF-?B signaling pathways . Positive_regulation EPHB2 EGFR 8981234 409049 The also *activates* [Ras/ERK] signaling , but produces proliferation instead of differentiation . Positive_regulation EPHB2 EGFR 9710602 526848 Down-regulation of expression through pretreatment of cells with EGF also *attenuated* [ERK] activation and Shc tyrosine phosphorylation in response to arsenite treatment . Positive_regulation EPHB2 EGFR 9931105 589005 Although a selective kinase inhibitor completely abolished Ang II-induced recruitment of Grb2 to EGFR and markedly *attenuated* Ang II-induced [ERK] activation , it had no effect on Ang II-induced PYK2 tyrosine phosphorylation or its association with c-Src and Grb2 . Positive_regulation EPHB2 EGR1 10506481 649281 In adult rat VSMCs , Ang II activates [ERK] and JNK , but weakly *induces* , a transcription factor implicated in PDGF-B chain gene expression , compared with newborn VSMCs . Positive_regulation EPHB2 EGR1 11473356 841590 Involvement of PKCalpha in mediating ERK activation was further confirmed by the inhibition of [ERK] and the subsequent gene *induction* with antisense oligonucleotides to PKCalpha . Positive_regulation EPHB2 EGR1 11948693 930254 Proliferation , *activation* of [ERK] , and biosynthesis of was completely inhibited in EGF or thrombin treated HaCaT cells by the MAP kinase kinase inhibitor PD98059 and by AG1487 , an EGF receptor-specific tyrosine kinase inhibitor . Positive_regulation EPHB2 EGR1 12680875 1077311 Since the intracellular signalling of SDF-1 induced neovascularization remains unclear , we studied in human umbilical arterial endothelial cells ( HUAEC ) the influence of SDF-1alpha on induction of the genes of and VEGF , as well as the *activation* of [extracellular regulated kinases (ERK)] 1/2 , which are all known to be involved in endothelial cell proliferation . Positive_regulation EPHB2 EGR1 18682391 1967680 Using specific pharmacological inhibitors and small interfering RNA technology , we determined that PKCdelta and [ERK] , but not p38 and JNK , mediate histamine *induced* expression . Positive_regulation EPHB2 EGR1 18783846 2012138 Moreover , diacylgycerol dependent protein kinase C isoenzymes and activation of extracellular signal regulated protein kinase ( [ERK] ) are *required* for glucose- , tolbutamide- and KCl induced expression . Positive_regulation EPHB2 EGR1 21224049 2379391 The accumulation of and GGPPS was *induced* by [MAPK/ERK] pathway activation when Beas-2B human bronchial epithelial cells were exposed to cigarette smoke extract (CSE) . Positive_regulation EPHB2 EGR1 23468876 2750146 EGR-1 siRNA also reduced *induced* [cRaf/MEK/ERK] phosphorylation by 80 % . Positive_regulation EPHB2 EIF2AK1 16267271 1502278 On the contrary , does not *activate* [ERK] and does not engage FPRL1 or any other G protein coupled receptor , but it activates an alternative pathway initiated by the formation of a triple complex ( uPAR-alpha3beta1-EGFR ) and resulting in the autotyrosine phosphorylation of EGFR . Positive_regulation EPHB2 EIF2AK4 18287093 1891423 Furthermore , the enhanced [ERK] phosphorylation following amino acid deprivation *required* kinase activity and eIF2alpha phosphorylation . Positive_regulation EPHB2 EIF2S1 18287093 1891424 Furthermore , the enhanced [ERK] phosphorylation following amino acid deprivation *required* GCN2 kinase activity and phosphorylation . Positive_regulation EPHB2 EIF3A 22025682 2527289 interferes with Raf-1 activation and eIF3a downregulation by small interfering RNA *enhances* [ERK] activation , early gene expression , DNA synthesis , expression of neuronal differentiation markers in PC12 cells , and Ras induced focus formation in NIH 3T3 cells . Positive_regulation EPHB2 EIF5A 23638878 2790776 Phosphorylation of [ERK] , p38 MAPK , and JNK was observed in *response* to adenovirus mediated over-expression of eIF5A1 or , along with phosphorylation and stabilization of the p53 tumor suppressor protein . Positive_regulation EPHB2 ELK1 11997521 939451 Both the catalytic activity and , to a much lesser extent , the Grb2 binding-tyrosyl phosphorylation sites of SHP-2 are required for maximal FGF-2 induced [Erk] activity and *transactivation* . Positive_regulation EPHB2 EMD 18719212 1955801 Treatment of gingival fibroblasts with EMD resulted in tyrosine phosphorylation of the EGFR , as assessed by immunoblotting and ELISA , while induced [ERK] *activation* and thymidine incorporation were markedly inhibited ( approximately 40-50 % ) by a specific EGFR tyrosine kinase inhibitor . Positive_regulation EPHB2 EMD 18719212 1955805 Taken together , these results indicate that , at least in human gingival fibroblasts , *induced* [ERK] activation and proliferation are partially due to a Src dependent , metalloproteinase mediated transactivation of EGFR . Positive_regulation EPHB2 EMD 19022376 2016971 These results provide proof for the hypothesis that altered expression of and A-type lamins *activates* [ERK] signaling , which in turn can cause cardiomyopathy . Positive_regulation EPHB2 EML4 21415216 2416606 Forced expression of *induced* marked activation of extracellular signal regulated kinase ( [ERK] ) and STAT3 , but not that of AKT . Positive_regulation EPHB2 ENC1 15208678 1281418 More importantly , we found that NRP/B mutants , but not wild-type ( wt ) , *increased* the activation of [ERK] and consequently promoted cell proliferation , attenuated caspase activation and suppressed the cellular apoptosis induced by the stressful stimulus cisplatin ( 10 microM ) . Positive_regulation EPHB2 EPHB1 12730243 1106911 We reduced the level of caveolin-1 in senescent human diploid fibroblasts using its antisense oligonucleotides and small interfering RNA , and this resulted in the restoration of normal growth factor responses such as the increased phosphorylation of [Erk] , the nuclear translocation of p-Erk , and the subsequent *activation* of upon epidermal growth factor stimulation . Positive_regulation EPHB2 EPHB1 16723736 1565507 This interaction , as well as *mediated* activation of extracellular-signal regulated kinase ( [ERK] ) , was abrogated by overexpression of a caveolin-1 mutant lacking a functional scaffolding domain . Positive_regulation EPHB2 EPHB6 19513565 2092557 Here , we show that expression of in A549 lung adenocarcinoma cells *led* to phosphorylation of the MAP kinase [ERK] . Positive_regulation EPHB2 EPHB6 19513565 2092558 Intriguingly , *induced* phosphorylation of [ERK] was uncoupled by activation of the Elk-1 transcriptional factor . Positive_regulation EPHB2 EPO 21887333 2474333 Aconitase regulation of erythropoiesis correlates with a novel licensing function in *induced* [ERK] signaling . Positive_regulation EPHB2 EPO 22674427 2715284 In this study , we aimed to investigate the influence of *induced* [ERK] signaling on the regulation of GATA-4 protein action . Positive_regulation EPHB2 EPO 23063677 2698672 Levels of calcineurin activity and *induced* phosphorylation of Akt and [ERK] were similar in GK and Wistar , though cytosolic HSP70 level was 50 % lower and mitochondrial HSP60 level was 60 % higher in GK . Positive_regulation EPHB2 EPS8 11244499 792315 Overexpression of p97Eps8 leads to cellular transformation : implication of pleckstrin homology domain in mediated [ERK] *activation* . Positive_regulation EPHB2 EPX 11443118 850435 Overexpression of Lyn induced constitutive phosphorylation of CrkL and activation of Erk , whereas that of a Lyn mutant lacking the tyrosine kinase domain attenuated the *induced* phosphorylation of CrkL and activation of [Erk] . Positive_regulation EPHB2 EPX 15249201 1271358 Conversely , treatment with anti-EPO and EPO receptor antibodies also reduced *induced* [ERK] ( 2 ) and NF-kappaB activation . Positive_regulation EPHB2 EPX 16435392 1527764 In this study we confirmed the presence of the erythropoietin (EPO) receptor on both cultured cortical neurons and PC12 cells and showed that can *induce* changes in p38 , [ERK] , and JNK signaling molecules in these cells . Positive_regulation EPHB2 EPX 17707437 1789103 *increased* Jak2 and [ERK] activity , decreased MMP expression , increased TIMP-4 expression , and prevented collagen degradation in IR hearts . Positive_regulation EPHB2 EPX 21860424 2574405 EpoR knockdown in melanoma cells resulted in diminished [ERK] phosphorylation in *response* to stimulation , decreased cell proliferation and increased response to the inhibitory effect of hypoxia and cisplatin in vitro . Positive_regulation EPHB2 EPX 21887333 2474335 This inhibition spares metabolic function but impedes *induced* [ERK] signaling and disturbs a newly identified ERK-aconitase physical interaction . Positive_regulation EPHB2 EPX 22674427 2715290 *induced* [ERK] activation further increased the association of GATA-4 with p300 . Positive_regulation EPHB2 EPX 23811561 2808182 Under hypoxic condition without reperfusion , *induced* [ERK] activation was associated with post-translational modification of GATA-4 , mediated by enhancement of phosphorylation of GATA-4 at Ser-105 . Positive_regulation EPHB2 EPX 23820731 2815855 *induced* a rapid activation of [ERK] and also phosphorylation of endogenous Raf . Positive_regulation EPHB2 EPX 24294939 2898983 Transporter expression in response to blocking *induced* activation of JAK-2 , [ERK] , and PI3K/Akt was changed to a different extent . Positive_regulation EPHB2 ERBB2 15572377 1368346 Here we applied a combination of computational modeling and quantitative experimental studies of the dynamic interactions between EGFR and and their downstream *activation* of [ERK] to understand this complex signaling system . Positive_regulation EPHB2 ERBB2 15572377 1368351 Our model suggests that transient amplification of ERK activity by HER2 arises predominantly from the 2-to-1 stoichiometry of receptor kinase to bound ligand in EGFR/HER2 heterodimers compared with the 1-to-1 stoichiometry of the EGFR homodimer , but alterations in receptor trafficking yielding increased EGFR sparing cause the sustained *mediated* enhancement of [ERK] signaling . Positive_regulation EPHB2 ERBB2 16357167 1492826 Constitutive activation of the extracellular signal regulated kinase ( ERK ) pathway also enhanced PDEF induced motility and invasion , suggesting that *activation* of the [ERK/mitogen] activated protein kinase by and CSF-1R/CSF-1 can cooperate with PDEF to promote motility and invasion . Positive_regulation EPHB2 ERBB2 21403841 2404528 Furthermore , we show that AR-mediated induction of [ERK] *requires* , and AR activity , in turn , regulates ErbB2 expression as an AR target gene . Positive_regulation EPHB2 ERBB2 21760527 2456246 We have in the current study compared the effects of Nimotuzumab and Cetuximab on binding of EGF as well as on inhibition of constitutive dimerization and downstream *activation* of [Erk] . Positive_regulation EPHB2 ERBB2 22988345 2674396 Downregulation of via siRNA *resulted* in a significant decrease in [ERK] phosphorylation and a 50 % reduction in IL-8 secretion . Positive_regulation EPHB2 ERBB2IP 15659388 1381925 Reducing expression using a targeted siRNA in primary cultures of Schwann cells *results* in altered cell-cell interactions , disruption of E-cadherin adherens junctions , increased cell proliferation , and elevated levels of phosphorylated [ERK] , all phenotypes observed in cells that lack merlin . Positive_regulation EPHB2 ERBB2IP 23711387 2801638 The inhibitory *role* of in [ERK] signaling has been demonstrated . Positive_regulation EPHB2 ERBB2IP 24711380 2935548 In conclusion , is an inhibitor of pathological cardiac hypertrophy , and this inhibition is *mediated* , at least in part , by modulating [ERK] signaling . Positive_regulation EPHB2 ERBB3 19878579 2160849 We found that HER3 signaling makes the strongest contribution to Akt activation and that , stimulation of either EGFR or *leads* to significant [Erk] activation . Positive_regulation EPHB2 EREG 23549083 2772622 Additionally , we demonstrated that fibroblast derived *requires* [ERK] activation to induce proliferation of intestinal epithelial cells ( IEC ) and tumor development in vivo . Positive_regulation EPHB2 ERRFI1 15696545 1382735 These findings suggest that may *increase* [ERK] activity , and that the C-terminal half of Gene33 may act less specifically in the absence of the N-terminal half , inducing JNK activity . Positive_regulation EPHB2 ERRFI1 21190978 2396795 Furthermore , *regulated* [ERK] phosphorylation independent from its effects on EGFR . Positive_regulation EPHB2 ERVK-6 18068154 1861727 In order to determine whether OXSI-2 inhibited Src family kinase mediated platelet responses , we evaluated its effect on Src family kinase (SFK) mediated signaling events in platelets , viz. Lyn mediated phosphorylation of Y352 on Syk , LAT-Y191 phosphorylation by Syk , and *mediated* phosphorylation of [ERK] . Positive_regulation EPHB2 ESAT 23867456 2835204 *activated* [ERK] and p38 MAPK phosphorylation and rapidly induced reactive oxygen species ( ROS ) production . Positive_regulation EPHB2 ESR1 18239068 1895714 Previous studies indicate that Nar impaired estrogen receptor (ER) alpha signaling by interfering with *mediated* activation of [ERK] and phosphoinositide 3-kinase signaling pathways in the absence of effects at the transcriptional level . Positive_regulation EPHB2 ESR1 19339617 2056697 These results demonstrate that E2-mediated neuroprotection and [ERK] activation *involve* activation of G-protein- and beta-arrestin mediated mechanisms . Positive_regulation EPHB2 ESR1 19775474 2147535 Testosterone *induces* [ERK] and Akt phosphorylation via the membrane initiated signaling pathways mediated by , suggesting a possible involvement of ER-alpha 36 in testosterone carcinogenesis . Positive_regulation EPHB2 ESR1 20484412 2333975 Rapid *activation* of [Erk] by progestins via an interaction of the progesterone receptor (PR) with the is critical for transcriptional activation of the mouse mammary tumor virus ( MMTV ) promoter and other progesterone target genes . Positive_regulation EPHB2 ESR1 22230296 2569222 Estrogen- and xenoestrogen induced [ERK] signaling in pituitary tumor cells *involves* interactions with G protein-ai and caveolin I . Positive_regulation EPHB2 ESR1 22306083 2570965 In fact , in GC-2 cells we observed that and GPER activation *caused* rapid [ERK] and c-Jun phosphorylation , bax up-regulation , events associated with apoptosis . Positive_regulation EPHB2 ESR2 15067372 1232035 Western blot shows that the activation of JNK signaling pathway , but not p38 and [ERK] , is *dependent* on through estrogen treatment and APP-C105 is also mediated through estrogen in activating MAPK signaling pathway . Positive_regulation EPHB2 ESR2 19220308 2086528 Specific agonists for ERalpha ( PPT ) and GPR30 ( G-1 ) , but not ( DPN ) , *activated* [ERK] in trigeminal ganglion neurons in vitro . Positive_regulation EPHB2 ESRRA 19920079 2171794 This synergistic effect is seen at the global transcriptional level , *requires* both the [ERK] and phosphoinositide 3-kinase (PI3K) signalling pathways and is mediated by the transcription factor . Positive_regulation EPHB2 ETFA 19765188 2153519 These results indicated that the up-regulation of [ERK] phosphorylation and the increase in proliferation of ASD astrocytes were *dependent* upon accumulation . Positive_regulation EPHB2 ETS1 19179641 2049252 Upregulation of , but not [ERK] *activation* , correlated with enhanced proliferative and migratory responses PPARgamma ( L/+ ) SMCs . Positive_regulation EPHB2 ETV6 12149229 970253 Our data reveal the requirement of [ERK] *activation* by ( 5-19 ) in Ba/F3 cells and suggest that TEL-JAK2 leukemogenic potential may be mediated in part through ERK1/2 . Positive_regulation EPHB2 EXT1 10801808 714468 In contrast , *activated* B-Raf kinase and [ERK] phosphorylation more poorly than Ha-Ras61L . Positive_regulation EPHB2 EXT2 10801808 714469 In contrast , *activated* B-Raf kinase and [ERK] phosphorylation more poorly than Ha-Ras61L . Positive_regulation EPHB2 EXT3 10801808 714470 In contrast , *activated* B-Raf kinase and [ERK] phosphorylation more poorly than Ha-Ras61L . Positive_regulation EPHB2 F10 15882255 1406440 *induced* the activation of [ERK] in mesangial cells and this activation was also completely inhibited by DX-9065a , but not inhibited by PAR1 antagonist . Positive_regulation EPHB2 F10 15882255 1406442 There results suggest that can *induce* mesangial cell proliferation through the activation of [ERK] via PAR2 in mesangial cells and that PAR2 may play a crucial role in the cell proliferation induced by factor Xa . Positive_regulation EPHB2 F11R 12958043 1174106 Our results show that is *required* for the bFGF induced [ERK] activation that leads to endothelial cell migration on vitronectin . Positive_regulation EPHB2 F2R 15858058 1400692 The mechanisms by which PAR-1 stimulates glial proliferation appear to be related to the ability of receptor signaling to *induce* sustained [extracellular receptor kinase (ERK)] activation . Positive_regulation EPHB2 F2R 15858058 1400693 In contrast to the transient activation of ERK by cytokines and growth factors , stimulation *induces* a sustained [ERK] activation through its coupling to multiple G-protein linked signaling pathways , including Rho kinase . Positive_regulation EPHB2 F2R 17267741 1704191 These findings support important profibrotic roles for plasmin that include *dependent* [ERK] signaling and EMT induction . Positive_regulation EPHB2 F2RL1 15882255 1406443 There results suggest that factor Xa can induce mesangial cell proliferation through the *activation* of [ERK] via in mesangial cells and that PAR2 may play a crucial role in the cell proliferation induced by factor Xa . Positive_regulation EPHB2 F2RL1 16336275 1491301 Both HAT and *induced* [ERK] phosphorylation ; Positive_regulation EPHB2 F2RL1 16336275 1491304 further , desensitization of with a brief exposure of cells to PAR-2 AP *resulted* in inhibition of HAT induced [ERK] phosphorylation , suggesting that HAT activates ERK through PAR-2 . Positive_regulation EPHB2 F2RL1 16336275 1491305 Moreover , PAR-2 AP induced AR gene expression subsequent to protein production in the cellular fraction through the ERK pathway indicating that *mediated* activation of [ERK] is essential for HAT induced AR production . Positive_regulation EPHB2 F2RL1 16867053 1592824 We found that selective activation of using the peptide SLIGKV augmented TNFalpha induced MMP-9 protein levels and *increased* [ERK] phosphorylation . Positive_regulation EPHB2 F2RL1 18755806 1980078 Although activation by the pretreatment with PAR2 activating peptide ( AP ) itself *increased* [ERK] phosphorylation in rat pancreas , the same treatment remarkably decreased caerulein induced activation of ERK and JNK principally by accelerating their dephosphorylation . Positive_regulation EPHB2 F2RL1 22613992 2603855 Inhibition of *suppressed* tryptase induced [ERK] and p38 MAPK pathway activation in microglia . Positive_regulation EPHB2 F9 16254036 1508543 To determine the key RAF isoform mediating *induced* [ERK] phosphorylation , we stably transfected doxycycline-inducible RET/PTC3 expressing thyroid PCCL3 cells with small interfering RNA vectors to induce selective knockdown of BRAF or CRAF . Positive_regulation EPHB2 F9 16254036 1508545 Conditional expression *induced* comparable [ERK] phosphorylation in CRAF knockdown and control cells but negligible ERK phosphorylation in BRAF knockdown cells . Positive_regulation EPHB2 FADD 19758790 2183419 Marked concomitant increases in the content of ( 48 % ) and the *activation* of [MEK-ERK] ( 46-79 % ) were quantified during the short-term expression of morphine sensitization ( SW 3 , in the absence of morphine challenge ) . Positive_regulation EPHB2 FAH 11532983 854466 Biochemical data suggest that *causes* [ERK] activation through a thiol regulated and tyrosine kinase dependent , but growth factor receptor- and protein kinase C-independent pathway . Positive_regulation EPHB2 FAM57A 15625016 1349210 Two major signaling pathways involved in cell proliferation , cell survival and anti-apoptosis were overexpressed and activated in response to CT120 : One is the Raf/MEK/Erk signal cascades and the other is the PI3K/Akt signal cascades , suggesting that might *contribute* , at least in part , to the constitutively activation of [Erk] and Akt in human lung cancer cells . Positive_regulation EPHB2 FAS 12545171 1051107 engagement *induces* neurite growth through [ERK] activation and p35 upregulation . Positive_regulation EPHB2 FAS 15093249 1237996 The *induced* [ERK] phosphorylation that we detect in C17 .2 cells suggests that in NSC Fas may function as a mediator of growth rather than death . Positive_regulation EPHB2 FAS 15454340 1301163 [ERK] activation by PMA did not *induce* death or upregulation , suggesting that Fas may be important for the induction of apoptosis and the existence of an additional factor activated by Dex which enables the cooperation between the Dex activated ERK and Fas pathways , during apoptosis of osteocytes . Positive_regulation EPHB2 FAS 15949415 1421255 In gastric cancer cell line SGC-7901 , *induced* [ERK] activation may suppress Fas mediated apoptosis . Positive_regulation EPHB2 FAS 15949415 1421256 *induced* [ERK] activation may confer gastric cancer cells ability to escape the immune surveillance . Positive_regulation EPHB2 FAS 18471522 1910396 *induced* EGFR and [Erk] phosphorylation were abolished after proteinase inhibition by GM6001 and in the presence of neutralizing epidermal growth factor antibodies , suggestive of a ligand dependent EGFR phosphorylation in response to CD95L . Positive_regulation EPHB2 FAS 20658220 2316951 To distinguish between the activation signalling and the death inducing pathway downstream of Fas , we generated a novel T cell line expressing a chimeric hCD8-FasC protein and found that stimulation with the anti-CD8 antibodies *induced* tyrosine phosphorylation of TCR-proximal proteins , activation of [Raf-1/ERK] , p38 and JNK , and increased expression of CD69 , , and Fas ligand . Positive_regulation EPHB2 FAS 21390183 2400553 Overexpression of in the adenocarcinoma cell lines induced robust apoptosis and , under conditions of pan-caspase inhibition , *resulted* in activation of [ERK] signaling . Positive_regulation EPHB2 FAS 21613217 2454265 Furthermore , increased phosphorylation of Src was demonstrated to mediate *induced* [ERK] activation and cell survival . Positive_regulation EPHB2 FAS 25086185 2956926 These data reveal a surprising sensitivity of K-Ras-driven cancer cells to suppression when stimulation of Akt and [ERK] was *prevented* . Positive_regulation EPHB2 FASLG 21257927 2469709 Similarly , primary human small airways epithelial cells released IL-8 in *response* to soluble , and this was abrogated by inhibition of JNK and [ERK] . Positive_regulation EPHB2 FAT1 11418135 830196 Biochemical analyses correlated [Erk] *activation* by with its stimulation of cell cycle progression . Positive_regulation EPHB2 FCGR1A 19833736 2169983 Co-ligation of LILRB4 considerably reduced *mediated* phosphorylation of Lck , Syk , LAT , [Erk] , and c-Cbl but not alpha-actinin-4 , suggesting selective inhibition of signaling molecules . Positive_regulation EPHB2 FCGR1A 20356573 2244957 Also , did not *activate* [ERK] in the nucleus , but was however able to stimulate an efficient calcium rise . Positive_regulation EPHB2 FCGR2A 10777525 686783 Cross linking of or FcgammaRIIIB *induces* p38 mitogen activated protein (MAP) kinase and [extracellular regulated kinase (ERK)] phosphorylation . Positive_regulation EPHB2 FCGR2A 10843711 700200 Homotypic and heterotypic cross linking of and/or Fc gamma RIIIb *resulted* in a rapid , transient increase in [ERK] and p38 activity , with maximal stimulation between 1 and 3 min . Fc gamma RIIa and Fc gamma RIIIb stimulated distinct patterns of ERK and p38 activity , and heterotypic cross linking failed to stimulate synergistic activation of either ERK or p38 activity . Positive_regulation EPHB2 FCGR2A 10843711 700210 Our data indicate that and Fc gamma RIIIb independently *activate* [ERK] and p38 . Positive_regulation EPHB2 FCGR2A 19342628 2056753 FcgammaRIIIB , but not , *promoted* a robust increase in phosphorylated [ERK] in the nucleus , and also efficient phosphorylation of the NF Elk-1 . Positive_regulation EPHB2 FCGR3B 10777525 686784 Cross linking of FcgammaRIIA or *induces* p38 mitogen activated protein (MAP) kinase and [extracellular regulated kinase (ERK)] phosphorylation . Positive_regulation EPHB2 FCGR3B 10843711 700201 Homotypic and heterotypic cross linking of Fc gamma RIIa and/or *resulted* in a rapid , transient increase in [ERK] and p38 activity , with maximal stimulation between 1 and 3 min . Fc gamma RIIa and Fc gamma RIIIb stimulated distinct patterns of ERK and p38 activity , and heterotypic cross linking failed to stimulate synergistic activation of either ERK or p38 activity . Positive_regulation EPHB2 FCGR3B 10843711 700211 Our data indicate that Fc gamma RIIa and independently *activate* [ERK] and p38 . Positive_regulation EPHB2 FCGR3B 19342628 2056754 , but not FcgammaRIIA , *promoted* a robust increase in phosphorylated [ERK] in the nucleus , and also efficient phosphorylation of the NF Elk-1 . Positive_regulation EPHB2 FCGR3B 19342628 2056755 *induced* nuclear phosphorylation of [ERK] , and of Elk-1 , was not affected by Syk , PI3K , or MEK inhibitors . Positive_regulation EPHB2 FCGR3B 19342628 2056777 Also , [ERK] , but not MEK , was constitutively present in the nucleus , and cross linking did not *increase* the levels of nuclear ERK or MEK . Positive_regulation EPHB2 FDPS 9593727 505791 Dominant negative mutants of Ras ( but not Rac or Cdc42 ) specifically inhibited [ERK] *activation* by and Myr-Fes , demonstrating that ERK activation occurs exclusively downstream of Ras . Positive_regulation EPHB2 FES 9593727 505792 Dominant negative mutants of Ras ( but not Rac or Cdc42 ) specifically inhibited [ERK] *activation* by v-Fps and , demonstrating that ERK activation occurs exclusively downstream of Ras . Positive_regulation EPHB2 FFAR2 21698257 2446936 SCFAs and phenylacetamide-1 also elicited dependent *activation* of PKB , p38 and [ERK] and these responses were sensitive to pertussis toxin , indicating a role for Gi proteins . Positive_regulation EPHB2 FGB 18690351 1949445 In human macrophages *stimulated* interleukin (IL)6 expression and [ERK] ( extracellular signal related kinase ) phosphorylation . Positive_regulation EPHB2 FGF1 11449001 835887 *induced* sustained activation of extracellular signal regulated kinase ( [ERK] ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation EPHB2 FGF1 11449001 835931 We also identify vitreous humor as an in vivo source of an FGF-like intercellular communication promoting activity and show that *induced* [ERK] activation in the intact lens is higher in the equatorial region than in polar and core fibers . Positive_regulation EPHB2 FGF1 11495895 860834 Forced expression of Sprouty2 and Sprouty4 inhibited *induced* [ERK] activation but did not affect EGF- or PDBu induced ERK activation . Positive_regulation EPHB2 FGF1 11684653 875766 Experiments with Fgf inhibitors reveal that [ERK] activation at this stage is totally *dependent* on signalling . Positive_regulation EPHB2 FGF1 12402043 1009368 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Positive_regulation EPHB2 FGF1 12899800 1118618 The intracellular PKC and [ERK] activity *increased* with in a dose dependent manner , Genistein suppressed the intracellular PKC and ERK activity also in a dose dependent manner . Positive_regulation EPHB2 FGF1 14973553 1212463 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 FGF1 15145928 1267534 Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires *induced* [ERK] and JNK signaling . Positive_regulation EPHB2 FGF1 16603339 1624451 We also showed that SefECTM associated with FGFR1 , and inhibited *induced* [ERK] activation in HEK293T cells . Positive_regulation EPHB2 FGF1 16831426 1586867 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Positive_regulation EPHB2 FGF1 16831426 1587462 We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of *induced* [ERK] activity . Positive_regulation EPHB2 FGF1 16857343 1672391 By repressing events upstream and/or downstream Ras , Sef inhibits *induced* [ERK] activation and cell proliferation . Positive_regulation EPHB2 FGF1 16888801 1672681 Spry2 inhibits *dependent* [ERK] activation and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Positive_regulation EPHB2 FGF1 17164422 1679067 Dusp6 ( Mkp3 ) is a negative feedback regulator of *stimulated* [ERK] signaling during mouse development . Positive_regulation EPHB2 FGF1 17368052 1760152 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Positive_regulation EPHB2 FGF1 17516543 1762043 Furthermore , we demonstrate that TGF-beta1 signaling can modulate EGF and *induced* [ERK-MAP] kinase activation by controlling Spry2 expression and function . Positive_regulation EPHB2 FGF1 17852407 1817835 *induced* a transient activation of [ERK] , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation EPHB2 FGF1 18216067 1903412 Phosphorylation of Akt , [ERK] and MEK were *induced* by in W/W cells but not in W/M cells . Positive_regulation EPHB2 FGF1 18625726 1954471 These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of *induced* [ERK] activation . Positive_regulation EPHB2 FGF1 18678649 1967478 This site is functional , since its mutation enhanced the repressive function of Sprouty2 on *induced* [Erk] signaling . Positive_regulation EPHB2 FGF1 19103198 2060627 We show that *stimulates* [ERK] in DCDMLs via the canonical Ras/Raf1 pathway , and that the reason that neither basal nor growth factor stimulated GJIC is blocked by activation of ERK is because it is not mediated by Cx43 . Positive_regulation EPHB2 FGF1 19137008 2037756 Those effects were dependent on the C-terminal cysteine-rich region , but not on the N-terminal region of Sprouty4 , which is critical for the suppression of mediated [ERK] *activation* . Positive_regulation EPHB2 FGF1 19713443 2168163 *induced* phosphorylation of Src , and phosphorylation of MEK , [ERK] and Ark was inhibited by Src inhibitors in rat astrocytes . Positive_regulation EPHB2 FGF1 21515689 2439542 The amitriptyline ( a tricyclic antidepressant ) -induced [ERK] activation was specifically and completely *inhibited* by tyrosine kinase inhibitors and siRNA for FGFR1 and -2 . Positive_regulation EPHB2 FGF1 9892010 586533 ERK ) and augments *stimulated* [ERK] activity . Positive_regulation EPHB2 FGF10 11449001 835888 *induced* sustained activation of extracellular signal regulated kinase ( [ERK] ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation EPHB2 FGF10 11449001 835932 We also identify vitreous humor as an in vivo source of an FGF-like intercellular communication promoting activity and show that *induced* [ERK] activation in the intact lens is higher in the equatorial region than in polar and core fibers . Positive_regulation EPHB2 FGF10 11495895 860835 Forced expression of Sprouty2 and Sprouty4 inhibited induced [ERK] *activation* but did not affect EGF- or PDBu induced ERK activation . Positive_regulation EPHB2 FGF10 11684653 875767 Experiments with Fgf inhibitors reveal that [ERK] activation at this stage is totally *dependent* on signalling . Positive_regulation EPHB2 FGF10 12402043 1009369 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Positive_regulation EPHB2 FGF10 14973553 1212464 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 FGF10 15145928 1267535 Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires *induced* [ERK] and JNK signaling . Positive_regulation EPHB2 FGF10 16603339 1624452 We also showed that SefECTM associated with FGFR1 , and inhibited induced [ERK] *activation* in HEK293T cells . Positive_regulation EPHB2 FGF10 16831426 1586868 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Positive_regulation EPHB2 FGF10 16831426 1587463 We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of *induced* [ERK] activity . Positive_regulation EPHB2 FGF10 16857343 1672392 By repressing events upstream and/or downstream Ras , Sef inhibits induced [ERK] *activation* and cell proliferation . Positive_regulation EPHB2 FGF10 16888801 1672682 Spry2 inhibits dependent [ERK] *activation* and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Positive_regulation EPHB2 FGF10 17164422 1679068 Dusp6 ( Mkp3 ) is a negative feedback regulator of *stimulated* [ERK] signaling during mouse development . Positive_regulation EPHB2 FGF10 17368052 1760153 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an dependent *activation* of [ERK] when loaded . Positive_regulation EPHB2 FGF10 17516543 1762044 Furthermore , we demonstrate that TGF-beta1 signaling can modulate EGF and induced [ERK-MAP] kinase *activation* by controlling Spry2 expression and function . Positive_regulation EPHB2 FGF10 17852407 1817836 *induced* a transient activation of [ERK] , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation EPHB2 FGF10 18625726 1954472 These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of induced [ERK] *activation* . Positive_regulation EPHB2 FGF10 18678649 1967479 This site is functional , since its mutation enhanced the repressive function of Sprouty2 on *induced* [Erk] signaling . Positive_regulation EPHB2 FGF10 19103198 2060628 We show that *stimulates* [ERK] in DCDMLs via the canonical Ras/Raf1 pathway , and that the reason that neither basal nor growth factor stimulated GJIC is blocked by activation of ERK is because it is not mediated by Cx43 . Positive_regulation EPHB2 FGF10 19137008 2037757 Those effects were dependent on the C-terminal cysteine-rich region , but not on the N-terminal region of Sprouty4 , which is critical for the suppression of mediated [ERK] *activation* . Positive_regulation EPHB2 FGF10 19805408 2187019 Addition of TCDD to UGS organ culture media did not alter *induced* [ERK] activation in UGS basal epithelium but prevented FGF10 induced BrdU incorporation and blocked FGF10 induced prostatic bud formation . Positive_regulation EPHB2 FGF10 21515689 2439543 The amitriptyline ( a tricyclic antidepressant ) -induced [ERK] activation was specifically and completely *inhibited* by tyrosine kinase inhibitors and siRNA for FGFR1 and -2 . Positive_regulation EPHB2 FGF10 9892010 586534 ERK ) and augments *stimulated* [ERK] activity . Positive_regulation EPHB2 FGF11 11449001 835889 *induced* sustained activation of extracellular signal regulated kinase ( [ERK] ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation EPHB2 FGF11 11449001 835933 We also identify vitreous humor as an in vivo source of an FGF-like intercellular communication promoting activity and show that induced [ERK] *activation* in the intact lens is higher in the equatorial region than in polar and core fibers . Positive_regulation EPHB2 FGF11 11495895 860836 Forced expression of Sprouty2 and Sprouty4 inhibited induced [ERK] *activation* but did not affect EGF- or PDBu induced ERK activation . Positive_regulation EPHB2 FGF11 11684653 875768 Experiments with Fgf inhibitors reveal that [ERK] activation at this stage is totally *dependent* on signalling . Positive_regulation EPHB2 FGF11 12402043 1009370 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Positive_regulation EPHB2 FGF11 14973553 1212465 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 FGF11 15145928 1267536 Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires *induced* [ERK] and JNK signaling . Positive_regulation EPHB2 FGF11 16603339 1624453 We also showed that SefECTM associated with FGFR1 , and inhibited *induced* [ERK] activation in HEK293T cells . Positive_regulation EPHB2 FGF11 16831426 1586869 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Positive_regulation EPHB2 FGF11 16831426 1587464 We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of *induced* [ERK] activity . Positive_regulation EPHB2 FGF11 16857343 1672393 By repressing events upstream and/or downstream Ras , Sef inhibits *induced* [ERK] activation and cell proliferation . Positive_regulation EPHB2 FGF11 16888801 1672683 Spry2 inhibits *dependent* [ERK] activation and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Positive_regulation EPHB2 FGF11 17164422 1679069 Dusp6 ( Mkp3 ) is a negative feedback regulator of *stimulated* [ERK] signaling during mouse development . Positive_regulation EPHB2 FGF11 17368052 1760154 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Positive_regulation EPHB2 FGF11 17516543 1762045 Furthermore , we demonstrate that TGF-beta1 signaling can modulate EGF and *induced* [ERK-MAP] kinase activation by controlling Spry2 expression and function . Positive_regulation EPHB2 FGF11 17852407 1817837 *induced* a transient activation of [ERK] , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation EPHB2 FGF11 18625726 1954473 These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of *induced* [ERK] activation . Positive_regulation EPHB2 FGF11 18678649 1967480 This site is functional , since its mutation enhanced the repressive function of Sprouty2 on *induced* [Erk] signaling . Positive_regulation EPHB2 FGF11 19103198 2060629 We show that *stimulates* [ERK] in DCDMLs via the canonical Ras/Raf1 pathway , and that the reason that neither basal nor growth factor stimulated GJIC is blocked by activation of ERK is because it is not mediated by Cx43 . Positive_regulation EPHB2 FGF11 19137008 2037758 Those effects were dependent on the C-terminal cysteine-rich region , but not on the N-terminal region of Sprouty4 , which is critical for the suppression of mediated [ERK] *activation* . Positive_regulation EPHB2 FGF11 21515689 2439544 The amitriptyline ( a tricyclic antidepressant ) -induced [ERK] activation was specifically and completely *inhibited* by tyrosine kinase inhibitors and siRNA for FGFR1 and -2 . Positive_regulation EPHB2 FGF11 9892010 586535 ERK ) and augments *stimulated* [ERK] activity . Positive_regulation EPHB2 FGF12 11449001 835890 *induced* sustained activation of extracellular signal regulated kinase ( [ERK] ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation EPHB2 FGF12 11449001 835934 We also identify vitreous humor as an in vivo source of an FGF-like intercellular communication promoting activity and show that *induced* [ERK] activation in the intact lens is higher in the equatorial region than in polar and core fibers . Positive_regulation EPHB2 FGF12 11495895 860837 Forced expression of Sprouty2 and Sprouty4 inhibited *induced* [ERK] activation but did not affect EGF- or PDBu induced ERK activation . Positive_regulation EPHB2 FGF12 11684653 875769 Experiments with Fgf inhibitors reveal that [ERK] activation at this stage is totally *dependent* on signalling . Positive_regulation EPHB2 FGF12 12402043 1009371 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Positive_regulation EPHB2 FGF12 14973553 1212466 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 FGF12 15145928 1267537 Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires *induced* [ERK] and JNK signaling . Positive_regulation EPHB2 FGF12 16603339 1624454 We also showed that SefECTM associated with FGFR1 , and inhibited induced [ERK] *activation* in HEK293T cells . Positive_regulation EPHB2 FGF12 16831426 1586870 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Positive_regulation EPHB2 FGF12 16831426 1587465 We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of *induced* [ERK] activity . Positive_regulation EPHB2 FGF12 16857343 1672394 By repressing events upstream and/or downstream Ras , Sef inhibits induced [ERK] *activation* and cell proliferation . Positive_regulation EPHB2 FGF12 16888801 1672684 Spry2 inhibits dependent [ERK] *activation* and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Positive_regulation EPHB2 FGF12 17164422 1679070 Dusp6 ( Mkp3 ) is a negative feedback regulator of *stimulated* [ERK] signaling during mouse development . Positive_regulation EPHB2 FGF12 17368052 1760155 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an dependent *activation* of [ERK] when loaded . Positive_regulation EPHB2 FGF12 17516543 1762046 Furthermore , we demonstrate that TGF-beta1 signaling can modulate EGF and induced [ERK-MAP] kinase *activation* by controlling Spry2 expression and function . Positive_regulation EPHB2 FGF12 17852407 1817838 *induced* a transient activation of [ERK] , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation EPHB2 FGF12 18625726 1954474 These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of induced [ERK] *activation* . Positive_regulation EPHB2 FGF12 18678649 1967481 This site is functional , since its mutation enhanced the repressive function of Sprouty2 on *induced* [Erk] signaling . Positive_regulation EPHB2 FGF12 19103198 2060630 We show that *stimulates* [ERK] in DCDMLs via the canonical Ras/Raf1 pathway , and that the reason that neither basal nor growth factor stimulated GJIC is blocked by activation of ERK is because it is not mediated by Cx43 . Positive_regulation EPHB2 FGF12 19137008 2037759 Those effects were dependent on the C-terminal cysteine-rich region , but not on the N-terminal region of Sprouty4 , which is critical for the suppression of mediated [ERK] *activation* . Positive_regulation EPHB2 FGF12 21515689 2439545 The amitriptyline ( a tricyclic antidepressant ) -induced [ERK] activation was specifically and completely *inhibited* by tyrosine kinase inhibitors and siRNA for FGFR1 and -2 . Positive_regulation EPHB2 FGF12 9892010 586536 ERK ) and augments *stimulated* [ERK] activity . Positive_regulation EPHB2 FGF13 11449001 835891 *induced* sustained activation of extracellular signal regulated kinase ( [ERK] ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation EPHB2 FGF13 11449001 835935 We also identify vitreous humor as an in vivo source of an FGF-like intercellular communication promoting activity and show that induced [ERK] *activation* in the intact lens is higher in the equatorial region than in polar and core fibers . Positive_regulation EPHB2 FGF13 11495895 860838 Forced expression of Sprouty2 and Sprouty4 inhibited induced [ERK] *activation* but did not affect EGF- or PDBu induced ERK activation . Positive_regulation EPHB2 FGF13 11684653 875770 Experiments with Fgf inhibitors reveal that [ERK] activation at this stage is totally *dependent* on signalling . Positive_regulation EPHB2 FGF13 12402043 1009372 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Positive_regulation EPHB2 FGF13 14973553 1212467 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 FGF13 15145928 1267538 Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires *induced* [ERK] and JNK signaling . Positive_regulation EPHB2 FGF13 16603339 1624455 We also showed that SefECTM associated with FGFR1 , and inhibited *induced* [ERK] activation in HEK293T cells . Positive_regulation EPHB2 FGF13 16831426 1586871 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Positive_regulation EPHB2 FGF13 16831426 1587466 We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of *induced* [ERK] activity . Positive_regulation EPHB2 FGF13 16857343 1672395 By repressing events upstream and/or downstream Ras , Sef inhibits *induced* [ERK] activation and cell proliferation . Positive_regulation EPHB2 FGF13 16888801 1672685 Spry2 inhibits *dependent* [ERK] activation and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Positive_regulation EPHB2 FGF13 17164422 1679071 Dusp6 ( Mkp3 ) is a negative feedback regulator of *stimulated* [ERK] signaling during mouse development . Positive_regulation EPHB2 FGF13 17368052 1760156 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Positive_regulation EPHB2 FGF13 17516543 1762047 Furthermore , we demonstrate that TGF-beta1 signaling can modulate EGF and *induced* [ERK-MAP] kinase activation by controlling Spry2 expression and function . Positive_regulation EPHB2 FGF13 17852407 1817839 *induced* a transient activation of [ERK] , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation EPHB2 FGF13 18625726 1954475 These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of *induced* [ERK] activation . Positive_regulation EPHB2 FGF13 18678649 1967482 This site is functional , since its mutation enhanced the repressive function of Sprouty2 on *induced* [Erk] signaling . Positive_regulation EPHB2 FGF13 19103198 2060631 We show that *stimulates* [ERK] in DCDMLs via the canonical Ras/Raf1 pathway , and that the reason that neither basal nor growth factor stimulated GJIC is blocked by activation of ERK is because it is not mediated by Cx43 . Positive_regulation EPHB2 FGF13 19137008 2037760 Those effects were dependent on the C-terminal cysteine-rich region , but not on the N-terminal region of Sprouty4 , which is critical for the suppression of mediated [ERK] *activation* . Positive_regulation EPHB2 FGF13 21515689 2439546 The amitriptyline ( a tricyclic antidepressant ) -induced [ERK] activation was specifically and completely *inhibited* by tyrosine kinase inhibitors and siRNA for FGFR1 and -2 . Positive_regulation EPHB2 FGF13 9892010 586537 ERK ) and augments *stimulated* [ERK] activity . Positive_regulation EPHB2 FGF14 11449001 835892 *induced* sustained activation of extracellular signal regulated kinase ( [ERK] ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation EPHB2 FGF14 11449001 835936 We also identify vitreous humor as an in vivo source of an FGF-like intercellular communication promoting activity and show that induced [ERK] *activation* in the intact lens is higher in the equatorial region than in polar and core fibers . Positive_regulation EPHB2 FGF14 11495895 860839 Forced expression of Sprouty2 and Sprouty4 inhibited *induced* [ERK] activation but did not affect EGF- or PDBu induced ERK activation . Positive_regulation EPHB2 FGF14 11684653 875771 Experiments with Fgf inhibitors reveal that [ERK] activation at this stage is totally *dependent* on signalling . Positive_regulation EPHB2 FGF14 12402043 1009373 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Positive_regulation EPHB2 FGF14 14973553 1212468 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 FGF14 15145928 1267539 Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires *induced* [ERK] and JNK signaling . Positive_regulation EPHB2 FGF14 16603339 1624456 We also showed that SefECTM associated with FGFR1 , and inhibited induced [ERK] *activation* in HEK293T cells . Positive_regulation EPHB2 FGF14 16831426 1586872 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Positive_regulation EPHB2 FGF14 16831426 1587467 We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of *induced* [ERK] activity . Positive_regulation EPHB2 FGF14 16857343 1672396 By repressing events upstream and/or downstream Ras , Sef inhibits *induced* [ERK] activation and cell proliferation . Positive_regulation EPHB2 FGF14 16888801 1672686 Spry2 inhibits dependent [ERK] *activation* and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Positive_regulation EPHB2 FGF14 17164422 1679072 Dusp6 ( Mkp3 ) is a negative feedback regulator of *stimulated* [ERK] signaling during mouse development . Positive_regulation EPHB2 FGF14 17368052 1760157 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an dependent *activation* of [ERK] when loaded . Positive_regulation EPHB2 FGF14 17516543 1762048 Furthermore , we demonstrate that TGF-beta1 signaling can modulate EGF and induced [ERK-MAP] kinase *activation* by controlling Spry2 expression and function . Positive_regulation EPHB2 FGF14 17852407 1817840 *induced* a transient activation of [ERK] , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation EPHB2 FGF14 18625726 1954476 These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of induced [ERK] *activation* . Positive_regulation EPHB2 FGF14 18678649 1967483 This site is functional , since its mutation enhanced the repressive function of Sprouty2 on *induced* [Erk] signaling . Positive_regulation EPHB2 FGF14 19103198 2060632 We show that *stimulates* [ERK] in DCDMLs via the canonical Ras/Raf1 pathway , and that the reason that neither basal nor growth factor stimulated GJIC is blocked by activation of ERK is because it is not mediated by Cx43 . Positive_regulation EPHB2 FGF14 19137008 2037761 Those effects were dependent on the C-terminal cysteine-rich region , but not on the N-terminal region of Sprouty4 , which is critical for the suppression of mediated [ERK] *activation* . Positive_regulation EPHB2 FGF14 21515689 2439547 The amitriptyline ( a tricyclic antidepressant ) -induced [ERK] activation was specifically and completely *inhibited* by tyrosine kinase inhibitors and siRNA for FGFR1 and -2 . Positive_regulation EPHB2 FGF14 9892010 586538 ERK ) and augments *stimulated* [ERK] activity . Positive_regulation EPHB2 FGF16 11449001 835893 *induced* sustained activation of extracellular signal regulated kinase ( [ERK] ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation EPHB2 FGF16 11449001 835937 We also identify vitreous humor as an in vivo source of an FGF-like intercellular communication promoting activity and show that *induced* [ERK] activation in the intact lens is higher in the equatorial region than in polar and core fibers . Positive_regulation EPHB2 FGF16 11495895 860840 Forced expression of Sprouty2 and Sprouty4 inhibited induced [ERK] *activation* but did not affect EGF- or PDBu induced ERK activation . Positive_regulation EPHB2 FGF16 11684653 875772 Experiments with Fgf inhibitors reveal that [ERK] activation at this stage is totally *dependent* on signalling . Positive_regulation EPHB2 FGF16 12402043 1009374 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Positive_regulation EPHB2 FGF16 14973553 1212469 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 FGF16 15145928 1267540 Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires *induced* [ERK] and JNK signaling . Positive_regulation EPHB2 FGF16 16603339 1624457 We also showed that SefECTM associated with FGFR1 , and inhibited *induced* [ERK] activation in HEK293T cells . Positive_regulation EPHB2 FGF16 16831426 1586873 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Positive_regulation EPHB2 FGF16 16831426 1587468 We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of *induced* [ERK] activity . Positive_regulation EPHB2 FGF16 16857343 1672397 By repressing events upstream and/or downstream Ras , Sef inhibits induced [ERK] *activation* and cell proliferation . Positive_regulation EPHB2 FGF16 16888801 1672687 Spry2 inhibits *dependent* [ERK] activation and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Positive_regulation EPHB2 FGF16 17164422 1679073 Dusp6 ( Mkp3 ) is a negative feedback regulator of *stimulated* [ERK] signaling during mouse development . Positive_regulation EPHB2 FGF16 17368052 1760158 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Positive_regulation EPHB2 FGF16 17516543 1762049 Furthermore , we demonstrate that TGF-beta1 signaling can modulate EGF and *induced* [ERK-MAP] kinase activation by controlling Spry2 expression and function . Positive_regulation EPHB2 FGF16 17852407 1817841 *induced* a transient activation of [ERK] , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation EPHB2 FGF16 18625726 1954477 These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of induced [ERK] *activation* . Positive_regulation EPHB2 FGF16 18678649 1967484 This site is functional , since its mutation enhanced the repressive function of Sprouty2 on *induced* [Erk] signaling . Positive_regulation EPHB2 FGF16 19103198 2060633 We show that *stimulates* [ERK] in DCDMLs via the canonical Ras/Raf1 pathway , and that the reason that neither basal nor growth factor stimulated GJIC is blocked by activation of ERK is because it is not mediated by Cx43 . Positive_regulation EPHB2 FGF16 19137008 2037762 Those effects were dependent on the C-terminal cysteine-rich region , but not on the N-terminal region of Sprouty4 , which is critical for the suppression of mediated [ERK] *activation* . Positive_regulation EPHB2 FGF16 21515689 2439548 The amitriptyline ( a tricyclic antidepressant ) -induced [ERK] activation was specifically and completely *inhibited* by tyrosine kinase inhibitors and siRNA for FGFR1 and -2 . Positive_regulation EPHB2 FGF16 9892010 586539 ERK ) and augments *stimulated* [ERK] activity . Positive_regulation EPHB2 FGF17 11449001 835894 *induced* sustained activation of extracellular signal regulated kinase ( [ERK] ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation EPHB2 FGF17 11449001 835938 We also identify vitreous humor as an in vivo source of an FGF-like intercellular communication promoting activity and show that induced [ERK] *activation* in the intact lens is higher in the equatorial region than in polar and core fibers . Positive_regulation EPHB2 FGF17 11495895 860841 Forced expression of Sprouty2 and Sprouty4 inhibited *induced* [ERK] activation but did not affect EGF- or PDBu induced ERK activation . Positive_regulation EPHB2 FGF17 11684653 875773 Experiments with Fgf inhibitors reveal that [ERK] activation at this stage is totally *dependent* on signalling . Positive_regulation EPHB2 FGF17 12402043 1009375 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Positive_regulation EPHB2 FGF17 14973553 1212470 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 FGF17 15145928 1267541 Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires *induced* [ERK] and JNK signaling . Positive_regulation EPHB2 FGF17 16603339 1624458 We also showed that SefECTM associated with FGFR1 , and inhibited induced [ERK] *activation* in HEK293T cells . Positive_regulation EPHB2 FGF17 16831426 1586874 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Positive_regulation EPHB2 FGF17 16831426 1587469 We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of *induced* [ERK] activity . Positive_regulation EPHB2 FGF17 16857343 1672398 By repressing events upstream and/or downstream Ras , Sef inhibits *induced* [ERK] activation and cell proliferation . Positive_regulation EPHB2 FGF17 16888801 1672688 Spry2 inhibits dependent [ERK] *activation* and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Positive_regulation EPHB2 FGF17 17164422 1679074 Dusp6 ( Mkp3 ) is a negative feedback regulator of *stimulated* [ERK] signaling during mouse development . Positive_regulation EPHB2 FGF17 17368052 1760159 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an dependent *activation* of [ERK] when loaded . Positive_regulation EPHB2 FGF17 17516543 1762050 Furthermore , we demonstrate that TGF-beta1 signaling can modulate EGF and induced [ERK-MAP] kinase *activation* by controlling Spry2 expression and function . Positive_regulation EPHB2 FGF17 17852407 1817842 *induced* a transient activation of [ERK] , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation EPHB2 FGF17 18625726 1954478 These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of induced [ERK] *activation* . Positive_regulation EPHB2 FGF17 18678649 1967485 This site is functional , since its mutation enhanced the repressive function of Sprouty2 on *induced* [Erk] signaling . Positive_regulation EPHB2 FGF17 19103198 2060634 We show that *stimulates* [ERK] in DCDMLs via the canonical Ras/Raf1 pathway , and that the reason that neither basal nor growth factor stimulated GJIC is blocked by activation of ERK is because it is not mediated by Cx43 . Positive_regulation EPHB2 FGF17 19137008 2037763 Those effects were dependent on the C-terminal cysteine-rich region , but not on the N-terminal region of Sprouty4 , which is critical for the suppression of mediated [ERK] *activation* . Positive_regulation EPHB2 FGF17 21515689 2439549 The amitriptyline ( a tricyclic antidepressant ) -induced [ERK] activation was specifically and completely *inhibited* by tyrosine kinase inhibitors and siRNA for FGFR1 and -2 . Positive_regulation EPHB2 FGF17 9892010 586540 ERK ) and augments *stimulated* [ERK] activity . Positive_regulation EPHB2 FGF18 11449001 835895 *induced* sustained activation of extracellular signal regulated kinase ( [ERK] ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation EPHB2 FGF18 11449001 835939 We also identify vitreous humor as an in vivo source of an FGF-like intercellular communication promoting activity and show that *induced* [ERK] activation in the intact lens is higher in the equatorial region than in polar and core fibers . Positive_regulation EPHB2 FGF18 11495895 860842 Forced expression of Sprouty2 and Sprouty4 inhibited induced [ERK] *activation* but did not affect EGF- or PDBu induced ERK activation . Positive_regulation EPHB2 FGF18 11684653 875774 Experiments with Fgf inhibitors reveal that [ERK] activation at this stage is totally *dependent* on signalling . Positive_regulation EPHB2 FGF18 12402043 1009376 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Positive_regulation EPHB2 FGF18 14973553 1212471 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 FGF18 15145928 1267542 Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires *induced* [ERK] and JNK signaling . Positive_regulation EPHB2 FGF18 15869918 1411283 Conversely , CNP and 8-bromo-cGMP strongly and dose-dependently inhibited the *induction* of [ERK] phosphorylation by FGF2 and without changing the level of FGFR-3 , although they did not affect the phosphorylation of STAT-1 . Positive_regulation EPHB2 FGF18 16603339 1624459 We also showed that SefECTM associated with FGFR1 , and inhibited *induced* [ERK] activation in HEK293T cells . Positive_regulation EPHB2 FGF18 16831426 1586875 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Positive_regulation EPHB2 FGF18 16831426 1587470 We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of *induced* [ERK] activity . Positive_regulation EPHB2 FGF18 16857343 1672399 By repressing events upstream and/or downstream Ras , Sef inhibits induced [ERK] *activation* and cell proliferation . Positive_regulation EPHB2 FGF18 16888801 1672689 Spry2 inhibits *dependent* [ERK] activation and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Positive_regulation EPHB2 FGF18 17164422 1679075 Dusp6 ( Mkp3 ) is a negative feedback regulator of *stimulated* [ERK] signaling during mouse development . Positive_regulation EPHB2 FGF18 17368052 1760160 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Positive_regulation EPHB2 FGF18 17516543 1762051 Furthermore , we demonstrate that TGF-beta1 signaling can modulate EGF and *induced* [ERK-MAP] kinase activation by controlling Spry2 expression and function . Positive_regulation EPHB2 FGF18 17852407 1817843 *induced* a transient activation of [ERK] , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation EPHB2 FGF18 18625726 1954479 These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of *induced* [ERK] activation . Positive_regulation EPHB2 FGF18 18678649 1967486 This site is functional , since its mutation enhanced the repressive function of Sprouty2 on *induced* [Erk] signaling . Positive_regulation EPHB2 FGF18 19103198 2060635 We show that *stimulates* [ERK] in DCDMLs via the canonical Ras/Raf1 pathway , and that the reason that neither basal nor growth factor stimulated GJIC is blocked by activation of ERK is because it is not mediated by Cx43 . Positive_regulation EPHB2 FGF18 19137008 2037764 Those effects were dependent on the C-terminal cysteine-rich region , but not on the N-terminal region of Sprouty4 , which is critical for the suppression of mediated [ERK] *activation* . Positive_regulation EPHB2 FGF18 21515689 2439550 The amitriptyline ( a tricyclic antidepressant ) -induced [ERK] activation was specifically and completely *inhibited* by tyrosine kinase inhibitors and siRNA for FGFR1 and -2 . Positive_regulation EPHB2 FGF18 9892010 586541 ERK ) and augments *stimulated* [ERK] activity . Positive_regulation EPHB2 FGF19 11449001 835896 *induced* sustained activation of extracellular signal regulated kinase ( [ERK] ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation EPHB2 FGF19 11449001 835940 We also identify vitreous humor as an in vivo source of an FGF-like intercellular communication promoting activity and show that *induced* [ERK] activation in the intact lens is higher in the equatorial region than in polar and core fibers . Positive_regulation EPHB2 FGF19 11495895 860843 Forced expression of Sprouty2 and Sprouty4 inhibited *induced* [ERK] activation but did not affect EGF- or PDBu induced ERK activation . Positive_regulation EPHB2 FGF19 11684653 875775 Experiments with Fgf inhibitors reveal that [ERK] activation at this stage is totally *dependent* on signalling . Positive_regulation EPHB2 FGF19 12402043 1009377 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Positive_regulation EPHB2 FGF19 14973553 1212472 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 FGF19 15145928 1267543 Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires *induced* [ERK] and JNK signaling . Positive_regulation EPHB2 FGF19 16603339 1624460 We also showed that SefECTM associated with FGFR1 , and inhibited induced [ERK] *activation* in HEK293T cells . Positive_regulation EPHB2 FGF19 16831426 1586876 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Positive_regulation EPHB2 FGF19 16831426 1587471 We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of *induced* [ERK] activity . Positive_regulation EPHB2 FGF19 16857343 1672400 By repressing events upstream and/or downstream Ras , Sef inhibits *induced* [ERK] activation and cell proliferation . Positive_regulation EPHB2 FGF19 16888801 1672690 Spry2 inhibits dependent [ERK] *activation* and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Positive_regulation EPHB2 FGF19 17164422 1679076 Dusp6 ( Mkp3 ) is a negative feedback regulator of *stimulated* [ERK] signaling during mouse development . Positive_regulation EPHB2 FGF19 17368052 1760161 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an dependent *activation* of [ERK] when loaded . Positive_regulation EPHB2 FGF19 17516543 1762052 Furthermore , we demonstrate that TGF-beta1 signaling can modulate EGF and induced [ERK-MAP] kinase *activation* by controlling Spry2 expression and function . Positive_regulation EPHB2 FGF19 17852407 1817844 *induced* a transient activation of [ERK] , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation EPHB2 FGF19 18625726 1954480 These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of induced [ERK] *activation* . Positive_regulation EPHB2 FGF19 18678649 1967487 This site is functional , since its mutation enhanced the repressive function of Sprouty2 on *induced* [Erk] signaling . Positive_regulation EPHB2 FGF19 19103198 2060636 We show that *stimulates* [ERK] in DCDMLs via the canonical Ras/Raf1 pathway , and that the reason that neither basal nor growth factor stimulated GJIC is blocked by activation of ERK is because it is not mediated by Cx43 . Positive_regulation EPHB2 FGF19 19137008 2037765 Those effects were dependent on the C-terminal cysteine-rich region , but not on the N-terminal region of Sprouty4 , which is critical for the suppression of mediated [ERK] *activation* . Positive_regulation EPHB2 FGF19 21515689 2439551 The amitriptyline ( a tricyclic antidepressant ) -induced [ERK] activation was specifically and completely *inhibited* by tyrosine kinase inhibitors and siRNA for FGFR1 and -2 . Positive_regulation EPHB2 FGF19 9892010 586542 ERK ) and augments *stimulated* [ERK] activity . Positive_regulation EPHB2 FGF2 10050071 592993 We demonstrate that angiostatin diminishes [ERK] *activation* by and vascular endothelial growth factor . Positive_regulation EPHB2 FGF2 10356298 618384 We have found that N-cadherin , as well as laminin ( LN ) and , can *activate* [ERK] in embryonic chick retinal neurons . Positive_regulation EPHB2 FGF2 10455028 638397 TGF-beta(1) had no inhibitory effect on [ERK] activation *induced* by PDGF-BB or . Positive_regulation EPHB2 FGF2 10455916 638715 Thus *induced* [ERK] activation mediates the endothelial response to wounding . Positive_regulation EPHB2 FGF2 10960064 726343 Thrombin ( 0.3 and 3 u ml(-1) ) and ( 0.3 and 3 nM ) *increased* [ERK] activity for more than 2 h and increased cell number , whereas ET-1 ( 100 nM ) transiently stimulated ERK activity and was non-mitogenic . Positive_regulation EPHB2 FGF2 11088001 764956 However , in these cells , somatostatin robustly activates the MAP kinase and augments *induced* stimulation of [ERK] . Positive_regulation EPHB2 FGF2 11171046 783691 PKC inhibitors blocked VEGF induced activation of ERK , MEK ( mitogen activated protein kinase kinase ) and the cytosolic phospholipase A(2) , but had little effect on [ERK] activation *induced* by . Positive_regulation EPHB2 FGF2 11279003 802964 In C2C12 myoblast cells , insulin-like growth factor-1 and *activate* [MAPK/Erk] , and both growth factors promote myoblast proliferation . Positive_regulation EPHB2 FGF2 11322784 807193 Exon 6-derived peptides caused release of bFGF from endothelial cells but inhibited *dependent* [ERK] activation , cell proliferation and angiogenesis . Positive_regulation EPHB2 FGF2 11327725 807659 These peptides also inhibited proliferation , angiogenesis , and [ERK] activation *induced* by with similar potency and efficacy . Positive_regulation EPHB2 FGF2 11449001 835897 *induced* sustained activation of extracellular signal regulated kinase ( [ERK] ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation EPHB2 FGF2 11449001 835941 We also identify vitreous humor as an in vivo source of an FGF-like intercellular communication promoting activity and show that *induced* [ERK] activation in the intact lens is higher in the equatorial region than in polar and core fibers . Positive_regulation EPHB2 FGF2 11495895 860844 Forced expression of Sprouty2 and Sprouty4 inhibited induced [ERK] *activation* but did not affect EGF- or PDBu induced ERK activation . Positive_regulation EPHB2 FGF2 11553671 858297 Pharmacologically increasing intracellular cAMP levels in cultured cortical astroglia by treatment with dbcAMP or forskolin attenuated *induced* [ERK] phosphorylation and glial cell proliferation . Positive_regulation EPHB2 FGF2 11553671 858298 Similarly , FGF-2 induced glial proliferation was attenuated in the presence of the MEK inhibitor , PD98059 , thus , confirming a direct correlation between induced [ERK] *activation* and glial cell proliferation . Positive_regulation EPHB2 FGF2 11684653 875776 Experiments with Fgf inhibitors reveal that [ERK] activation at this stage is totally *dependent* on signalling . Positive_regulation EPHB2 FGF2 11919166 926037 In addition , *induced* [ERK] activation mediates endothelial cell migration in response to wounding without a significant effect on proliferation . Positive_regulation EPHB2 FGF2 11926263 926755 NS-417 also enhanced [ERK] activation *induced* by 10 minutes stimulation with NGF , or EGF in PC12 cells . Positive_regulation EPHB2 FGF2 11997521 939452 Both the catalytic activity and , to a much lesser extent , the Grb2 binding-tyrosyl phosphorylation sites of SHP-2 are required for maximal *induced* [Erk] activity and Elk-1 transactivation . Positive_regulation EPHB2 FGF2 11997521 939453 The constitutively active mutant of SHP-2 induces hyper-tyrosyl phosphorylation of FRS-2 alpha but fails to stimulate or potentiate either *induced* [Erk] activation or Elk-1 transactivation . Positive_regulation EPHB2 FGF2 12032827 948130 However , only immobilized *induces* a long lasting activation of extracellular signal regulated kinases ( 1/2 ) ( [ERK] ( 1/2 ) ) and cell proliferation that was inhibited by the ERK ( 1/2 ) inhibitor PD 098059 and the tyrosine kinase ( TK ) inhibitor tyrphostin 23 , pointing to the engagement of FGF receptor (FGFR) at the basal side of the cell . Positive_regulation EPHB2 FGF2 12384403 998642 To exclude the possibility that PF-4 inhibited the binding of FGF2 to only one FGF receptor , preferentially activating the ERK pathway , we investigated the effect of PF-4 on *induced* [ERK] and Akt phosphorylation , using mutant heparan sulfate-deficient Chinese hamster ovary cells transfected with the FGF-R1 cDNA . Positive_regulation EPHB2 FGF2 12402043 1009378 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Positive_regulation EPHB2 FGF2 12717697 1083907 These studies indicate that agrin augments a transient early phosphorylation of [ERK] in the *presence* of , and augments and sustains FGF-2 mediated increases in c-fos phosphorylation . Positive_regulation EPHB2 FGF2 12958043 1174107 Our results show that JAM-1 is required for the *induced* [ERK] activation that leads to endothelial cell migration on vitronectin . Positive_regulation EPHB2 FGF2 14872495 1208470 Cyclical loading of articular cartilage causes *dependent* activation of [ERK] and synthesis of TIMP-1 . Positive_regulation EPHB2 FGF2 14963006 1227900 PGI2 or iloprost at the IP receptor inhibited basal ERK phosphorylation with IC50 values of 10 nmol/L. Iloprost also attenuated the sustained activation of [ERK] *induced* by endothelin-1 or . Positive_regulation EPHB2 FGF2 14973553 1212473 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 FGF2 15145928 1267544 Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires *induced* [ERK] and JNK signaling . Positive_regulation EPHB2 FGF2 15194433 1259762 *activated* phospholipase Cgamma , protein kinase B , and [Erk] and p38 MAP kinases . Positive_regulation EPHB2 FGF2 15249425 1274206 Thrombin and *stimulated* increases in [ERK] phosphorylation and cyclin D1 mRNA and protein levels were not influenced by SB 203580 pre-treatment . Positive_regulation EPHB2 FGF2 15310753 1333336 *induced* sustained activation of [ERK] and transient activation of p38 ( MAPK ) , which was not associated with cell death . Positive_regulation EPHB2 FGF2 15869918 1411284 Conversely , CNP and 8-bromo-cGMP strongly and dose-dependently inhibited the *induction* of [ERK] phosphorylation by and FGF18 without changing the level of FGFR-3 , although they did not affect the phosphorylation of STAT-1 . Positive_regulation EPHB2 FGF2 16137228 1450581 *activates* [ERK] and induces c-fos in human embryonic stem cell line MizhES1 . Positive_regulation EPHB2 FGF2 16339969 1491783 Efficient suppression of *induced* [ERK] activation by the cooperative interaction among mammalian Sprouty isoforms . Positive_regulation EPHB2 FGF2 16387627 1505757 We have recently discovered that release of and the subsequent activation of fibroblast growth factor receptor 1 are *required* for maximal induction by PDGF of [ERK] and of human smooth muscle cell proliferation . Positive_regulation EPHB2 FGF2 16464862 1548098 In contrast , p38 MAPK inhibitors had no detectable effect on the [ERK] activation *induced* by or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Positive_regulation EPHB2 FGF2 16603339 1624461 We also showed that SefECTM associated with FGFR1 , and inhibited *induced* [ERK] activation in HEK293T cells . Positive_regulation EPHB2 FGF2 16831426 1586877 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Positive_regulation EPHB2 FGF2 16831426 1587472 We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of *induced* [ERK] activity . Positive_regulation EPHB2 FGF2 16840547 1613062 Because S179D PRL and have both been shown to *activate* [ERK] , the effect of S179D PRL on bFGF induced ERK signaling was examined . Positive_regulation EPHB2 FGF2 16840547 1613066 S179D PRL blocked [ERK] phosphorylation in *response* to , whereas continued coincubation caused a delayed and prolonged activation of ERK . Positive_regulation EPHB2 FGF2 16840547 1613069 We conclude that S179D PRL blocks *induced* [ERK] signaling and yet uses ERK in a different time frame to elevate p21 and activate the extrinsic pathway . Positive_regulation EPHB2 FGF2 16857343 1672401 By repressing events upstream and/or downstream Ras , Sef inhibits induced [ERK] *activation* and cell proliferation . Positive_regulation EPHB2 FGF2 16888801 1672691 Spry2 inhibits *dependent* [ERK] activation and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Positive_regulation EPHB2 FGF2 17145761 1686997 We also determined which PKC isoform is involved in *mediated* activation of [Erk] . Positive_regulation EPHB2 FGF2 17145761 1686998 Moreover , treatment with PKClambda/zeta pseudosubstrate lead to significant reduction of *mediated* activation of [Erk] , suggesting involvement of an atypical PKC . Positive_regulation EPHB2 FGF2 17164422 1679077 Dusp6 ( Mkp3 ) is a negative feedback regulator of *stimulated* [ERK] signaling during mouse development . Positive_regulation EPHB2 FGF2 17192847 1701827 Analyzing the signaling pathways implicated in angiogenesis , we observed that the *induced* [ERK] phosphorylation was antagonized by Met-F-AEA , and we found that p38 MAPK was involved in Met-F-AEA induced apoptosis . Positive_regulation EPHB2 FGF2 17335076 1712171 Additionally , *enhanced* MEK1/2 phosphorylation and [ERK] activation/nuclear translocation , which culminated in increased activity of AP-1 mediated gene transcription . Positive_regulation EPHB2 FGF2 17368052 1760162 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Positive_regulation EPHB2 FGF2 17368052 1760196 Loading induced [ERK] activation was *dependent* upon the presence and concentration of pericellular , suggesting a functional role for this matrix bound growth factor in chondrocyte mechanotransduction . Positive_regulation EPHB2 FGF2 17385725 1727721 We examined early signaling events in the CB/CMZ and found that or Shh *induced* a robust [Erk] phosphorylation during the early stages of retina regeneration . Positive_regulation EPHB2 FGF2 17498671 1750869 Co-treatment with maximal concentrations of either IGF-1 or BDNF enhanced *stimulated* Akt and [ERK] activation . Positive_regulation EPHB2 FGF2 17516543 1762053 Furthermore , we demonstrate that TGF-beta1 signaling can modulate EGF and *induced* [ERK-MAP] kinase activation by controlling Spry2 expression and function . Positive_regulation EPHB2 FGF2 17540764 1767317 We examined this issue by quantifying the dynamics of [Erk] signaling *induced* by epidermal growth factor , , and platelet derived growth factor ( PDGF ) in NIH-3T3 fibroblasts . Positive_regulation EPHB2 FGF2 17570829 1753787 *increased* the phosphorylation of [ERK] , but did not significantly increase the expression of osteoblast gene markers . Positive_regulation EPHB2 FGF2 17763874 1817242 All three growth factors were shown to phosphorylate immediately extracellular-signal regulated kinases ( ERKs ) , while the stimulation by especially *resulted* in sustained [ERK] phosphorylation . Positive_regulation EPHB2 FGF2 17852407 1817845 *induced* a transient activation of [ERK] , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation EPHB2 FGF2 18263590 1884945 *promoted* the association between [ERK] and pGSK3beta ( Tyr-216 ) . Positive_regulation EPHB2 FGF2 18625726 1954481 These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of *induced* [ERK] activation . Positive_regulation EPHB2 FGF2 18656513 1972825 For comparison , we also evaluated the role of upstream signalling cascades on *mediated* phosphorylation of [ERK] , Akt , and CREB and found that FGF2 required the activity of both FGFR and Src-family kinases for phosphorylation of ERK , Akt , and CREB . Positive_regulation EPHB2 FGF2 18678649 1967488 This site is functional , since its mutation enhanced the repressive function of Sprouty2 on *induced* [Erk] signaling . Positive_regulation EPHB2 FGF2 18692028 1961229 Dexamethasone ( 10 ( -6 ) M ) substantially reduced *stimulated* [ERK] activation at 10 min , COX-2 mRNA and protein expression at 30 and 240 min , respectively , and prostaglandin E ( 2 ) synthesis at 8 h. Dexamethasone ( 10 ( -6 ) M ) also significantly decreased mRNA expression of FGFR1 and FGFR2 at basal and bFGF stimulated conditions at 10 min . Positive_regulation EPHB2 FGF2 19103198 2060637 We show that *stimulates* [ERK] in DCDMLs via the canonical Ras/Raf1 pathway , and that the reason that neither basal nor growth factor stimulated GJIC is blocked by activation of ERK is because it is not mediated by Cx43 . Positive_regulation EPHB2 FGF2 19137008 2037766 Those effects were dependent on the C-terminal cysteine-rich region , but not on the N-terminal region of Sprouty4 , which is critical for the suppression of mediated [ERK] *activation* . Positive_regulation EPHB2 FGF2 19461929 2084822 Finally , we demonstrated that treatment *induces* [ERK] phosphorylation in the pigmented epithelia 10 days after retinectomy , and that inhibition of the MAPK pathway significantly decreases the amount of retina regenerated at 30 days post-operation . Positive_regulation EPHB2 FGF2 19683577 2162870 Down-regulation of Sprouty2 promoted elongative axon growth by adult sensory neurons accompanied by enhanced *induced* activation of [ERK] and Ras , whereas Sprouty2 overexpression inhibited axon growth . Positive_regulation EPHB2 FGF2 20016498 2232268 In premalignant JB6 cells , stimulation ( 1 ) *increases* cellular [phospho-ERK] and phospho-c-Jun levels , ( 2 ) increases serum dependent cell proliferation , ( 3 ) induces an apparent epithelial-to-mesenchymal transition , and ( 4 ) induces the persistent nuclear-cytosolic oscillation of an ERK1-green fluorescent protein ( ERK1-GFP ) chimera . Positive_regulation EPHB2 FGF2 20460816 2275700 *induces* [ERK] phosphorylation through Grb2 and PKC during quiescent myogenic cell activation . Positive_regulation EPHB2 FGF2 20506264 2307834 We next investigated the signaling pathway that mediated the effect of bFGF on TSP50 transcription , and identified that *induced* the phosphorylation of [ERK] and Sp1 . Positive_regulation EPHB2 FGF2 21464042 2428043 We showed that medroxyprogesterone acetate ( MPA ) and *induced* cell proliferation and activation of [ERK] , AKT , and STAT5 in T47D and in murine C4-HI cells . Positive_regulation EPHB2 FGF2 21508382 2418629 The sulfated chitosan ( SCS ) and the sulfated benzaldehyde chitosan ( SBCS ) significantly inhibited cell proliferation , induced apoptosis and blocked the *induced* phosphorylation of [ERK] in MCF-7 cells , SBCS had better inhibitory effects and a lower IC ( 50 ) compared to SCS . Positive_regulation EPHB2 FGF2 21515689 2439552 The amitriptyline ( a tricyclic antidepressant ) -induced [ERK] activation was specifically and completely *inhibited* by tyrosine kinase inhibitors and siRNA for FGFR1 and -2 . Positive_regulation EPHB2 FGF2 21663947 2459807 We found that the hSef expression was positively regulated by FGF2 induced MAPK/ERK signaling and inversely , hSef expression efficiently inhibited the activity of *induced* [MAPK/ERK] signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Positive_regulation EPHB2 FGF2 22277757 2575618 The PKCd independent *activation* of [ERK] by was confirmed by Western blotting , as was the Cx43 dependent enhancement of ERK activation . Positive_regulation EPHB2 FGF2 23059005 2716689 The effects of luminescent ruthenium ( II ) polypyridyl functionalized selenium nanoparticles on *induced* angiogenesis and [AKT/ERK] signaling . Positive_regulation EPHB2 FGF2 23829214 2808910 [ERK] *activation* by caused an effect opposite to that of the 2i condition , namely , it dispersed colonies of cells even from early embryos in all species examined . Positive_regulation EPHB2 FGF2 24357720 2911196 Activation of H-Ras not only upregulated *induced* activation of the [Erk] mitogen activated protein kinases ( MAPK3 and MAPK1 ) , but also suppressed TGFß induced activation of Smad2 by modulating Smad2 phosphorylation by MAPKs . Positive_regulation EPHB2 FGF2 24445144 2942451 Immunofluorescence staining showed that *promoted* the translocation of phosphorylated [ERK] to the nucleus and increased brachyury expression . Positive_regulation EPHB2 FGF2 24466271 2907770 Reversibility of the TGF-ß induced myofibroblastic phenotype depends , in part , on *induced* [ERK/MAP] kinase signaling . Positive_regulation EPHB2 FGF2 9892010 586543 ERK ) and augments *stimulated* [ERK] activity . Positive_regulation EPHB2 FGF20 11449001 835898 *induced* sustained activation of extracellular signal regulated kinase ( [ERK] ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation EPHB2 FGF20 11449001 835942 We also identify vitreous humor as an in vivo source of an FGF-like intercellular communication promoting activity and show that induced [ERK] *activation* in the intact lens is higher in the equatorial region than in polar and core fibers . Positive_regulation EPHB2 FGF20 11495895 860845 Forced expression of Sprouty2 and Sprouty4 inhibited *induced* [ERK] activation but did not affect EGF- or PDBu induced ERK activation . Positive_regulation EPHB2 FGF20 11684653 875777 Experiments with Fgf inhibitors reveal that [ERK] activation at this stage is totally *dependent* on signalling . Positive_regulation EPHB2 FGF20 12402043 1009379 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Positive_regulation EPHB2 FGF20 14973553 1212474 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 FGF20 15145928 1267545 Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires *induced* [ERK] and JNK signaling . Positive_regulation EPHB2 FGF20 16603339 1624462 We also showed that SefECTM associated with FGFR1 , and inhibited induced [ERK] *activation* in HEK293T cells . Positive_regulation EPHB2 FGF20 16831426 1586878 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Positive_regulation EPHB2 FGF20 16831426 1587473 We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of *induced* [ERK] activity . Positive_regulation EPHB2 FGF20 16857343 1672402 By repressing events upstream and/or downstream Ras , Sef inhibits *induced* [ERK] activation and cell proliferation . Positive_regulation EPHB2 FGF20 16888801 1672692 Spry2 inhibits dependent [ERK] *activation* and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Positive_regulation EPHB2 FGF20 17164422 1679078 Dusp6 ( Mkp3 ) is a negative feedback regulator of *stimulated* [ERK] signaling during mouse development . Positive_regulation EPHB2 FGF20 17368052 1760163 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an dependent *activation* of [ERK] when loaded . Positive_regulation EPHB2 FGF20 17516543 1762054 Furthermore , we demonstrate that TGF-beta1 signaling can modulate EGF and induced [ERK-MAP] kinase *activation* by controlling Spry2 expression and function . Positive_regulation EPHB2 FGF20 17852407 1817846 *induced* a transient activation of [ERK] , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation EPHB2 FGF20 18625726 1954482 These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of induced [ERK] *activation* . Positive_regulation EPHB2 FGF20 18678649 1967489 This site is functional , since its mutation enhanced the repressive function of Sprouty2 on *induced* [Erk] signaling . Positive_regulation EPHB2 FGF20 19103198 2060638 We show that *stimulates* [ERK] in DCDMLs via the canonical Ras/Raf1 pathway , and that the reason that neither basal nor growth factor stimulated GJIC is blocked by activation of ERK is because it is not mediated by Cx43 . Positive_regulation EPHB2 FGF20 19137008 2037767 Those effects were dependent on the C-terminal cysteine-rich region , but not on the N-terminal region of Sprouty4 , which is critical for the suppression of mediated [ERK] *activation* . Positive_regulation EPHB2 FGF20 21515689 2439553 The amitriptyline ( a tricyclic antidepressant ) -induced [ERK] activation was specifically and completely *inhibited* by tyrosine kinase inhibitors and siRNA for FGFR1 and -2 . Positive_regulation EPHB2 FGF20 9892010 586544 ERK ) and augments *stimulated* [ERK] activity . Positive_regulation EPHB2 FGF21 11449001 835899 *induced* sustained activation of extracellular signal regulated kinase ( [ERK] ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation EPHB2 FGF21 11449001 835943 We also identify vitreous humor as an in vivo source of an FGF-like intercellular communication promoting activity and show that *induced* [ERK] activation in the intact lens is higher in the equatorial region than in polar and core fibers . Positive_regulation EPHB2 FGF21 11495895 860846 Forced expression of Sprouty2 and Sprouty4 inhibited induced [ERK] *activation* but did not affect EGF- or PDBu induced ERK activation . Positive_regulation EPHB2 FGF21 11684653 875778 Experiments with Fgf inhibitors reveal that [ERK] activation at this stage is totally *dependent* on signalling . Positive_regulation EPHB2 FGF21 12402043 1009380 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Positive_regulation EPHB2 FGF21 14973553 1212475 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 FGF21 15145928 1267546 Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires *induced* [ERK] and JNK signaling . Positive_regulation EPHB2 FGF21 16603339 1624463 We also showed that SefECTM associated with FGFR1 , and inhibited *induced* [ERK] activation in HEK293T cells . Positive_regulation EPHB2 FGF21 16831426 1586879 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Positive_regulation EPHB2 FGF21 16831426 1587474 We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of *induced* [ERK] activity . Positive_regulation EPHB2 FGF21 16857343 1672403 By repressing events upstream and/or downstream Ras , Sef inhibits induced [ERK] *activation* and cell proliferation . Positive_regulation EPHB2 FGF21 16888801 1672693 Spry2 inhibits *dependent* [ERK] activation and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Positive_regulation EPHB2 FGF21 17164422 1679079 Dusp6 ( Mkp3 ) is a negative feedback regulator of *stimulated* [ERK] signaling during mouse development . Positive_regulation EPHB2 FGF21 17368052 1760164 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Positive_regulation EPHB2 FGF21 17516543 1762055 Furthermore , we demonstrate that TGF-beta1 signaling can modulate EGF and *induced* [ERK-MAP] kinase activation by controlling Spry2 expression and function . Positive_regulation EPHB2 FGF21 17852407 1817847 *induced* a transient activation of [ERK] , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation EPHB2 FGF21 18625726 1954483 These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of *induced* [ERK] activation . Positive_regulation EPHB2 FGF21 18678649 1967490 This site is functional , since its mutation enhanced the repressive function of Sprouty2 on *induced* [Erk] signaling . Positive_regulation EPHB2 FGF21 19103198 2060639 We show that *stimulates* [ERK] in DCDMLs via the canonical Ras/Raf1 pathway , and that the reason that neither basal nor growth factor stimulated GJIC is blocked by activation of ERK is because it is not mediated by Cx43 . Positive_regulation EPHB2 FGF21 19137008 2037768 Those effects were dependent on the C-terminal cysteine-rich region , but not on the N-terminal region of Sprouty4 , which is critical for the suppression of mediated [ERK] *activation* . Positive_regulation EPHB2 FGF21 21515689 2439554 The amitriptyline ( a tricyclic antidepressant ) -induced [ERK] activation was specifically and completely *inhibited* by tyrosine kinase inhibitors and siRNA for FGFR1 and -2 . Positive_regulation EPHB2 FGF21 9892010 586545 ERK ) and augments *stimulated* [ERK] activity . Positive_regulation EPHB2 FGF22 11449001 835900 *induced* sustained activation of extracellular signal regulated kinase ( [ERK] ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation EPHB2 FGF22 11449001 835944 We also identify vitreous humor as an in vivo source of an FGF-like intercellular communication promoting activity and show that induced [ERK] *activation* in the intact lens is higher in the equatorial region than in polar and core fibers . Positive_regulation EPHB2 FGF22 11495895 860847 Forced expression of Sprouty2 and Sprouty4 inhibited *induced* [ERK] activation but did not affect EGF- or PDBu induced ERK activation . Positive_regulation EPHB2 FGF22 11684653 875779 Experiments with Fgf inhibitors reveal that [ERK] activation at this stage is totally *dependent* on signalling . Positive_regulation EPHB2 FGF22 12402043 1009381 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Positive_regulation EPHB2 FGF22 14973553 1212476 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 FGF22 15145928 1267547 Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires *induced* [ERK] and JNK signaling . Positive_regulation EPHB2 FGF22 16603339 1624464 We also showed that SefECTM associated with FGFR1 , and inhibited induced [ERK] *activation* in HEK293T cells . Positive_regulation EPHB2 FGF22 16831426 1586880 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Positive_regulation EPHB2 FGF22 16831426 1587475 We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of *induced* [ERK] activity . Positive_regulation EPHB2 FGF22 16857343 1672404 By repressing events upstream and/or downstream Ras , Sef inhibits *induced* [ERK] activation and cell proliferation . Positive_regulation EPHB2 FGF22 16888801 1672694 Spry2 inhibits dependent [ERK] *activation* and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Positive_regulation EPHB2 FGF22 17164422 1679080 Dusp6 ( Mkp3 ) is a negative feedback regulator of *stimulated* [ERK] signaling during mouse development . Positive_regulation EPHB2 FGF22 17368052 1760165 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an dependent *activation* of [ERK] when loaded . Positive_regulation EPHB2 FGF22 17516543 1762056 Furthermore , we demonstrate that TGF-beta1 signaling can modulate EGF and induced [ERK-MAP] kinase *activation* by controlling Spry2 expression and function . Positive_regulation EPHB2 FGF22 17852407 1817848 *induced* a transient activation of [ERK] , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation EPHB2 FGF22 18625726 1954484 These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of induced [ERK] *activation* . Positive_regulation EPHB2 FGF22 18678649 1967491 This site is functional , since its mutation enhanced the repressive function of Sprouty2 on *induced* [Erk] signaling . Positive_regulation EPHB2 FGF22 19103198 2060640 We show that *stimulates* [ERK] in DCDMLs via the canonical Ras/Raf1 pathway , and that the reason that neither basal nor growth factor stimulated GJIC is blocked by activation of ERK is because it is not mediated by Cx43 . Positive_regulation EPHB2 FGF22 19137008 2037769 Those effects were dependent on the C-terminal cysteine-rich region , but not on the N-terminal region of Sprouty4 , which is critical for the suppression of mediated [ERK] *activation* . Positive_regulation EPHB2 FGF22 21515689 2439555 The amitriptyline ( a tricyclic antidepressant ) -induced [ERK] activation was specifically and completely *inhibited* by tyrosine kinase inhibitors and siRNA for FGFR1 and -2 . Positive_regulation EPHB2 FGF22 9892010 586546 ERK ) and augments *stimulated* [ERK] activity . Positive_regulation EPHB2 FGF23 11449001 835901 *induced* sustained activation of extracellular signal regulated kinase ( [ERK] ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation EPHB2 FGF23 11449001 835945 We also identify vitreous humor as an in vivo source of an FGF-like intercellular communication promoting activity and show that *induced* [ERK] activation in the intact lens is higher in the equatorial region than in polar and core fibers . Positive_regulation EPHB2 FGF23 11495895 860848 Forced expression of Sprouty2 and Sprouty4 inhibited induced [ERK] *activation* but did not affect EGF- or PDBu induced ERK activation . Positive_regulation EPHB2 FGF23 11684653 875780 Experiments with Fgf inhibitors reveal that [ERK] activation at this stage is totally *dependent* on signalling . Positive_regulation EPHB2 FGF23 12402043 1009382 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Positive_regulation EPHB2 FGF23 14973553 1212477 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 FGF23 15145928 1267548 Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires *induced* [ERK] and JNK signaling . Positive_regulation EPHB2 FGF23 16436388 1527835 In addition , Klotho significantly enhanced the ability of to *induce* phosphorylation of FGF receptor substrate and [ERK] in various types of cells . Positive_regulation EPHB2 FGF23 16603339 1624465 We also showed that SefECTM associated with FGFR1 , and inhibited *induced* [ERK] activation in HEK293T cells . Positive_regulation EPHB2 FGF23 16831426 1586881 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Positive_regulation EPHB2 FGF23 16831426 1587476 We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of *induced* [ERK] activity . Positive_regulation EPHB2 FGF23 16857343 1672405 By repressing events upstream and/or downstream Ras , Sef inhibits induced [ERK] *activation* and cell proliferation . Positive_regulation EPHB2 FGF23 16888801 1672695 Spry2 inhibits *dependent* [ERK] activation and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Positive_regulation EPHB2 FGF23 17164422 1679081 Dusp6 ( Mkp3 ) is a negative feedback regulator of *stimulated* [ERK] signaling during mouse development . Positive_regulation EPHB2 FGF23 17368052 1760166 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Positive_regulation EPHB2 FGF23 17516543 1762057 Furthermore , we demonstrate that TGF-beta1 signaling can modulate EGF and *induced* [ERK-MAP] kinase activation by controlling Spry2 expression and function . Positive_regulation EPHB2 FGF23 17852407 1817849 *induced* a transient activation of [ERK] , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation EPHB2 FGF23 18625726 1954485 These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of *induced* [ERK] activation . Positive_regulation EPHB2 FGF23 18678649 1967492 This site is functional , since its mutation enhanced the repressive function of Sprouty2 on *induced* [Erk] signaling . Positive_regulation EPHB2 FGF23 19103198 2060641 We show that *stimulates* [ERK] in DCDMLs via the canonical Ras/Raf1 pathway , and that the reason that neither basal nor growth factor stimulated GJIC is blocked by activation of ERK is because it is not mediated by Cx43 . Positive_regulation EPHB2 FGF23 19137008 2037770 Those effects were dependent on the C-terminal cysteine-rich region , but not on the N-terminal region of Sprouty4 , which is critical for the suppression of mediated [ERK] *activation* . Positive_regulation EPHB2 FGF23 21515689 2439556 The amitriptyline ( a tricyclic antidepressant ) -induced [ERK] activation was specifically and completely *inhibited* by tyrosine kinase inhibitors and siRNA for FGFR1 and -2 . Positive_regulation EPHB2 FGF23 23872713 2854476 Both inhibitors decreased ERK phosphorylation in the kidneys and inhibited *induced* [ERK] phosphorylation in vitro in a dose dependent manner . Positive_regulation EPHB2 FGF23 9892010 586547 ERK ) and augments *stimulated* [ERK] activity . Positive_regulation EPHB2 FGF3 11449001 835902 *induced* sustained activation of extracellular signal regulated kinase ( [ERK] ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation EPHB2 FGF3 11449001 835946 We also identify vitreous humor as an in vivo source of an FGF-like intercellular communication promoting activity and show that induced [ERK] *activation* in the intact lens is higher in the equatorial region than in polar and core fibers . Positive_regulation EPHB2 FGF3 11495895 860849 Forced expression of Sprouty2 and Sprouty4 inhibited *induced* [ERK] activation but did not affect EGF- or PDBu induced ERK activation . Positive_regulation EPHB2 FGF3 11684653 875781 Experiments with Fgf inhibitors reveal that [ERK] activation at this stage is totally *dependent* on signalling . Positive_regulation EPHB2 FGF3 12402043 1009383 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Positive_regulation EPHB2 FGF3 14973553 1212478 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 FGF3 15145928 1267549 Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires *induced* [ERK] and JNK signaling . Positive_regulation EPHB2 FGF3 16603339 1624466 We also showed that SefECTM associated with FGFR1 , and inhibited *induced* [ERK] activation in HEK293T cells . Positive_regulation EPHB2 FGF3 16831426 1586882 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Positive_regulation EPHB2 FGF3 16831426 1587477 We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of *induced* [ERK] activity . Positive_regulation EPHB2 FGF3 16857343 1672406 By repressing events upstream and/or downstream Ras , Sef inhibits *induced* [ERK] activation and cell proliferation . Positive_regulation EPHB2 FGF3 16888801 1672696 Spry2 inhibits dependent [ERK] *activation* and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Positive_regulation EPHB2 FGF3 17164422 1679082 Dusp6 ( Mkp3 ) is a negative feedback regulator of *stimulated* [ERK] signaling during mouse development . Positive_regulation EPHB2 FGF3 17368052 1760167 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an dependent *activation* of [ERK] when loaded . Positive_regulation EPHB2 FGF3 17516543 1762058 Furthermore , we demonstrate that TGF-beta1 signaling can modulate EGF and induced [ERK-MAP] kinase *activation* by controlling Spry2 expression and function . Positive_regulation EPHB2 FGF3 17852407 1817850 *induced* a transient activation of [ERK] , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation EPHB2 FGF3 18625726 1954486 These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of induced [ERK] *activation* . Positive_regulation EPHB2 FGF3 18678649 1967493 This site is functional , since its mutation enhanced the repressive function of Sprouty2 on *induced* [Erk] signaling . Positive_regulation EPHB2 FGF3 19103198 2060642 We show that *stimulates* [ERK] in DCDMLs via the canonical Ras/Raf1 pathway , and that the reason that neither basal nor growth factor stimulated GJIC is blocked by activation of ERK is because it is not mediated by Cx43 . Positive_regulation EPHB2 FGF3 19137008 2037771 Those effects were dependent on the C-terminal cysteine-rich region , but not on the N-terminal region of Sprouty4 , which is critical for the suppression of mediated [ERK] *activation* . Positive_regulation EPHB2 FGF3 21515689 2439557 The amitriptyline ( a tricyclic antidepressant ) -induced [ERK] activation was specifically and completely *inhibited* by tyrosine kinase inhibitors and siRNA for FGFR1 and -2 . Positive_regulation EPHB2 FGF3 9892010 586548 ERK ) and augments *stimulated* [ERK] activity . Positive_regulation EPHB2 FGF4 11449001 835903 *induced* sustained activation of extracellular signal regulated kinase ( [ERK] ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation EPHB2 FGF4 11449001 835947 We also identify vitreous humor as an in vivo source of an FGF-like intercellular communication promoting activity and show that *induced* [ERK] activation in the intact lens is higher in the equatorial region than in polar and core fibers . Positive_regulation EPHB2 FGF4 11495895 860850 Forced expression of Sprouty2 and Sprouty4 inhibited induced [ERK] *activation* but did not affect EGF- or PDBu induced ERK activation . Positive_regulation EPHB2 FGF4 11684653 875782 Experiments with Fgf inhibitors reveal that [ERK] activation at this stage is totally *dependent* on signalling . Positive_regulation EPHB2 FGF4 12402043 1009384 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Positive_regulation EPHB2 FGF4 14973553 1212479 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 FGF4 15145928 1267550 Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires *induced* [ERK] and JNK signaling . Positive_regulation EPHB2 FGF4 16603339 1624467 We also showed that SefECTM associated with FGFR1 , and inhibited *induced* [ERK] activation in HEK293T cells . Positive_regulation EPHB2 FGF4 16831426 1586883 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Positive_regulation EPHB2 FGF4 16831426 1587478 We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of *induced* [ERK] activity . Positive_regulation EPHB2 FGF4 16857343 1672407 By repressing events upstream and/or downstream Ras , Sef inhibits induced [ERK] *activation* and cell proliferation . Positive_regulation EPHB2 FGF4 16888801 1672697 Spry2 inhibits *dependent* [ERK] activation and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Positive_regulation EPHB2 FGF4 17164422 1679083 Dusp6 ( Mkp3 ) is a negative feedback regulator of *stimulated* [ERK] signaling during mouse development . Positive_regulation EPHB2 FGF4 17368052 1760168 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Positive_regulation EPHB2 FGF4 17516543 1762059 Furthermore , we demonstrate that TGF-beta1 signaling can modulate EGF and *induced* [ERK-MAP] kinase activation by controlling Spry2 expression and function . Positive_regulation EPHB2 FGF4 17852407 1817851 *induced* a transient activation of [ERK] , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation EPHB2 FGF4 18625726 1954487 These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of *induced* [ERK] activation . Positive_regulation EPHB2 FGF4 18678649 1967494 This site is functional , since its mutation enhanced the repressive function of Sprouty2 on *induced* [Erk] signaling . Positive_regulation EPHB2 FGF4 19103198 2060643 We show that *stimulates* [ERK] in DCDMLs via the canonical Ras/Raf1 pathway , and that the reason that neither basal nor growth factor stimulated GJIC is blocked by activation of ERK is because it is not mediated by Cx43 . Positive_regulation EPHB2 FGF4 19137008 2037772 Those effects were dependent on the C-terminal cysteine-rich region , but not on the N-terminal region of Sprouty4 , which is critical for the suppression of mediated [ERK] *activation* . Positive_regulation EPHB2 FGF4 21515689 2439558 The amitriptyline ( a tricyclic antidepressant ) -induced [ERK] activation was specifically and completely *inhibited* by tyrosine kinase inhibitors and siRNA for FGFR1 and -2 . Positive_regulation EPHB2 FGF4 9892010 586549 ERK ) and augments *stimulated* [ERK] activity . Positive_regulation EPHB2 FGF5 11449001 835904 *induced* sustained activation of extracellular signal regulated kinase ( [ERK] ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation EPHB2 FGF5 11449001 835948 We also identify vitreous humor as an in vivo source of an FGF-like intercellular communication promoting activity and show that induced [ERK] *activation* in the intact lens is higher in the equatorial region than in polar and core fibers . Positive_regulation EPHB2 FGF5 11495895 860851 Forced expression of Sprouty2 and Sprouty4 inhibited *induced* [ERK] activation but did not affect EGF- or PDBu induced ERK activation . Positive_regulation EPHB2 FGF5 11684653 875783 Experiments with Fgf inhibitors reveal that [ERK] activation at this stage is totally *dependent* on signalling . Positive_regulation EPHB2 FGF5 12402043 1009385 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Positive_regulation EPHB2 FGF5 14973553 1212480 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 FGF5 15145928 1267551 Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires *induced* [ERK] and JNK signaling . Positive_regulation EPHB2 FGF5 16603339 1624468 We also showed that SefECTM associated with FGFR1 , and inhibited *induced* [ERK] activation in HEK293T cells . Positive_regulation EPHB2 FGF5 16831426 1586884 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Positive_regulation EPHB2 FGF5 16831426 1587479 We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of *induced* [ERK] activity . Positive_regulation EPHB2 FGF5 16857343 1672408 By repressing events upstream and/or downstream Ras , Sef inhibits *induced* [ERK] activation and cell proliferation . Positive_regulation EPHB2 FGF5 16888801 1672698 Spry2 inhibits dependent [ERK] *activation* and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Positive_regulation EPHB2 FGF5 17164422 1679084 Dusp6 ( Mkp3 ) is a negative feedback regulator of *stimulated* [ERK] signaling during mouse development . Positive_regulation EPHB2 FGF5 17368052 1760169 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an dependent *activation* of [ERK] when loaded . Positive_regulation EPHB2 FGF5 17516543 1762060 Furthermore , we demonstrate that TGF-beta1 signaling can modulate EGF and induced [ERK-MAP] kinase *activation* by controlling Spry2 expression and function . Positive_regulation EPHB2 FGF5 17852407 1817852 *induced* a transient activation of [ERK] , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation EPHB2 FGF5 18625726 1954488 These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of induced [ERK] *activation* . Positive_regulation EPHB2 FGF5 18678649 1967495 This site is functional , since its mutation enhanced the repressive function of Sprouty2 on *induced* [Erk] signaling . Positive_regulation EPHB2 FGF5 19103198 2060644 We show that *stimulates* [ERK] in DCDMLs via the canonical Ras/Raf1 pathway , and that the reason that neither basal nor growth factor stimulated GJIC is blocked by activation of ERK is because it is not mediated by Cx43 . Positive_regulation EPHB2 FGF5 19137008 2037773 Those effects were dependent on the C-terminal cysteine-rich region , but not on the N-terminal region of Sprouty4 , which is critical for the suppression of mediated [ERK] *activation* . Positive_regulation EPHB2 FGF5 21515689 2439559 The amitriptyline ( a tricyclic antidepressant ) -induced [ERK] activation was specifically and completely *inhibited* by tyrosine kinase inhibitors and siRNA for FGFR1 and -2 . Positive_regulation EPHB2 FGF5 9892010 586550 ERK ) and augments *stimulated* [ERK] activity . Positive_regulation EPHB2 FGF6 11449001 835905 *induced* sustained activation of extracellular signal regulated kinase ( [ERK] ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation EPHB2 FGF6 11449001 835949 We also identify vitreous humor as an in vivo source of an FGF-like intercellular communication promoting activity and show that *induced* [ERK] activation in the intact lens is higher in the equatorial region than in polar and core fibers . Positive_regulation EPHB2 FGF6 11495895 860852 Forced expression of Sprouty2 and Sprouty4 inhibited induced [ERK] *activation* but did not affect EGF- or PDBu induced ERK activation . Positive_regulation EPHB2 FGF6 11684653 875784 Experiments with Fgf inhibitors reveal that [ERK] activation at this stage is totally *dependent* on signalling . Positive_regulation EPHB2 FGF6 12402043 1009386 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Positive_regulation EPHB2 FGF6 14973553 1212481 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 FGF6 15145928 1267552 Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires *induced* [ERK] and JNK signaling . Positive_regulation EPHB2 FGF6 16603339 1624469 We also showed that SefECTM associated with FGFR1 , and inhibited induced [ERK] *activation* in HEK293T cells . Positive_regulation EPHB2 FGF6 16831426 1586885 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Positive_regulation EPHB2 FGF6 16831426 1587480 We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of *induced* [ERK] activity . Positive_regulation EPHB2 FGF6 16857343 1672409 By repressing events upstream and/or downstream Ras , Sef inhibits induced [ERK] *activation* and cell proliferation . Positive_regulation EPHB2 FGF6 16888801 1672699 Spry2 inhibits *dependent* [ERK] activation and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Positive_regulation EPHB2 FGF6 17164422 1679085 Dusp6 ( Mkp3 ) is a negative feedback regulator of *stimulated* [ERK] signaling during mouse development . Positive_regulation EPHB2 FGF6 17368052 1760170 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Positive_regulation EPHB2 FGF6 17516543 1762061 Furthermore , we demonstrate that TGF-beta1 signaling can modulate EGF and *induced* [ERK-MAP] kinase activation by controlling Spry2 expression and function . Positive_regulation EPHB2 FGF6 17852407 1817853 *induced* a transient activation of [ERK] , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation EPHB2 FGF6 18625726 1954489 These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of *induced* [ERK] activation . Positive_regulation EPHB2 FGF6 18678649 1967496 This site is functional , since its mutation enhanced the repressive function of Sprouty2 on *induced* [Erk] signaling . Positive_regulation EPHB2 FGF6 19103198 2060645 We show that *stimulates* [ERK] in DCDMLs via the canonical Ras/Raf1 pathway , and that the reason that neither basal nor growth factor stimulated GJIC is blocked by activation of ERK is because it is not mediated by Cx43 . Positive_regulation EPHB2 FGF6 19137008 2037774 Those effects were dependent on the C-terminal cysteine-rich region , but not on the N-terminal region of Sprouty4 , which is critical for the suppression of mediated [ERK] *activation* . Positive_regulation EPHB2 FGF6 21515689 2439560 The amitriptyline ( a tricyclic antidepressant ) -induced [ERK] activation was specifically and completely *inhibited* by tyrosine kinase inhibitors and siRNA for FGFR1 and -2 . Positive_regulation EPHB2 FGF6 9892010 586551 ERK ) and augments *stimulated* [ERK] activity . Positive_regulation EPHB2 FGF7 11449001 835906 *induced* sustained activation of extracellular signal regulated kinase ( [ERK] ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation EPHB2 FGF7 11449001 835950 We also identify vitreous humor as an in vivo source of an FGF-like intercellular communication promoting activity and show that *induced* [ERK] activation in the intact lens is higher in the equatorial region than in polar and core fibers . Positive_regulation EPHB2 FGF7 11495895 860853 Forced expression of Sprouty2 and Sprouty4 inhibited *induced* [ERK] activation but did not affect EGF- or PDBu induced ERK activation . Positive_regulation EPHB2 FGF7 11684653 875785 Experiments with Fgf inhibitors reveal that [ERK] activation at this stage is totally *dependent* on signalling . Positive_regulation EPHB2 FGF7 12402043 1009387 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Positive_regulation EPHB2 FGF7 14973553 1212482 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 FGF7 15145928 1267553 Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires *induced* [ERK] and JNK signaling . Positive_regulation EPHB2 FGF7 16603339 1624470 We also showed that SefECTM associated with FGFR1 , and inhibited *induced* [ERK] activation in HEK293T cells . Positive_regulation EPHB2 FGF7 16831426 1586886 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Positive_regulation EPHB2 FGF7 16831426 1587481 We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of *induced* [ERK] activity . Positive_regulation EPHB2 FGF7 16857343 1672410 By repressing events upstream and/or downstream Ras , Sef inhibits *induced* [ERK] activation and cell proliferation . Positive_regulation EPHB2 FGF7 16888801 1672700 Spry2 inhibits dependent [ERK] *activation* and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Positive_regulation EPHB2 FGF7 17164422 1679086 Dusp6 ( Mkp3 ) is a negative feedback regulator of *stimulated* [ERK] signaling during mouse development . Positive_regulation EPHB2 FGF7 17368052 1760171 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an dependent *activation* of [ERK] when loaded . Positive_regulation EPHB2 FGF7 17516543 1762062 Furthermore , we demonstrate that TGF-beta1 signaling can modulate EGF and induced [ERK-MAP] kinase *activation* by controlling Spry2 expression and function . Positive_regulation EPHB2 FGF7 17852407 1817854 *induced* a transient activation of [ERK] , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation EPHB2 FGF7 18625726 1954490 These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of induced [ERK] *activation* . Positive_regulation EPHB2 FGF7 18678649 1967497 This site is functional , since its mutation enhanced the repressive function of Sprouty2 on *induced* [Erk] signaling . Positive_regulation EPHB2 FGF7 19103198 2060646 We show that *stimulates* [ERK] in DCDMLs via the canonical Ras/Raf1 pathway , and that the reason that neither basal nor growth factor stimulated GJIC is blocked by activation of ERK is because it is not mediated by Cx43 . Positive_regulation EPHB2 FGF7 19137008 2037775 Those effects were dependent on the C-terminal cysteine-rich region , but not on the N-terminal region of Sprouty4 , which is critical for the suppression of mediated [ERK] *activation* . Positive_regulation EPHB2 FGF7 21515689 2439561 The amitriptyline ( a tricyclic antidepressant ) -induced [ERK] activation was specifically and completely *inhibited* by tyrosine kinase inhibitors and siRNA for FGFR1 and -2 . Positive_regulation EPHB2 FGF7 9892010 586552 ERK ) and augments *stimulated* [ERK] activity . Positive_regulation EPHB2 FGF8 11449001 835907 *induced* sustained activation of extracellular signal regulated kinase ( [ERK] ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation EPHB2 FGF8 11449001 835951 We also identify vitreous humor as an in vivo source of an FGF-like intercellular communication promoting activity and show that induced [ERK] *activation* in the intact lens is higher in the equatorial region than in polar and core fibers . Positive_regulation EPHB2 FGF8 11495895 860854 Forced expression of Sprouty2 and Sprouty4 inhibited induced [ERK] *activation* but did not affect EGF- or PDBu induced ERK activation . Positive_regulation EPHB2 FGF8 11684653 875786 Experiments with Fgf inhibitors reveal that [ERK] activation at this stage is totally *dependent* on signalling . Positive_regulation EPHB2 FGF8 12402043 1009388 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Positive_regulation EPHB2 FGF8 12766772 1094160 Here we show that during chick , mouse and zebrafish limb/fin development , a known [MAPK/ERK] regulator , Mkp3 , is *induced* in the mesenchyme by signalling , through the PI3K/Akt pathway . Positive_regulation EPHB2 FGF8 14973553 1212483 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 FGF8 15145928 1267554 Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires *induced* [ERK] and JNK signaling . Positive_regulation EPHB2 FGF8 15294862 1283124 *activated* [ERK] while Fgf8a or a lower dose of Fgf8b did not activate ERK in the mes/metencephalon . Positive_regulation EPHB2 FGF8 16603339 1624471 We also showed that SefECTM associated with FGFR1 , and inhibited induced [ERK] *activation* in HEK293T cells . Positive_regulation EPHB2 FGF8 16801134 1579397 Our results show that high level of syndecan-1 is associated with a decreased magnitude and duration of the *induced* [Erk] phosphorylation . Positive_regulation EPHB2 FGF8 16831426 1586887 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Positive_regulation EPHB2 FGF8 16831426 1587482 We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of *induced* [ERK] activity . Positive_regulation EPHB2 FGF8 16857343 1672411 By repressing events upstream and/or downstream Ras , Sef inhibits induced [ERK] *activation* and cell proliferation . Positive_regulation EPHB2 FGF8 16888801 1672701 Spry2 inhibits *dependent* [ERK] activation and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Positive_regulation EPHB2 FGF8 17164422 1679087 Dusp6 ( Mkp3 ) is a negative feedback regulator of *stimulated* [ERK] signaling during mouse development . Positive_regulation EPHB2 FGF8 17368052 1760172 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Positive_regulation EPHB2 FGF8 17516543 1762063 Furthermore , we demonstrate that TGF-beta1 signaling can modulate EGF and *induced* [ERK-MAP] kinase activation by controlling Spry2 expression and function . Positive_regulation EPHB2 FGF8 17852407 1817855 *induced* a transient activation of [ERK] , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation EPHB2 FGF8 18625726 1954491 These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of *induced* [ERK] activation . Positive_regulation EPHB2 FGF8 18678649 1967498 This site is functional , since its mutation enhanced the repressive function of Sprouty2 on *induced* [Erk] signaling . Positive_regulation EPHB2 FGF8 19103198 2060647 We show that *stimulates* [ERK] in DCDMLs via the canonical Ras/Raf1 pathway , and that the reason that neither basal nor growth factor stimulated GJIC is blocked by activation of ERK is because it is not mediated by Cx43 . Positive_regulation EPHB2 FGF8 19137008 2037776 Those effects were dependent on the C-terminal cysteine-rich region , but not on the N-terminal region of Sprouty4 , which is critical for the suppression of mediated [ERK] *activation* . Positive_regulation EPHB2 FGF8 20434519 2282500 Notably , *induced* [ERK] and SAPK/JNK phosphorylation in granulosa cells , in which ERK activation was further enhanced by FSH and oocytes . Positive_regulation EPHB2 FGF8 21515689 2439562 The amitriptyline ( a tricyclic antidepressant ) -induced [ERK] activation was specifically and completely *inhibited* by tyrosine kinase inhibitors and siRNA for FGFR1 and -2 . Positive_regulation EPHB2 FGF8 9892010 586553 ERK ) and augments *stimulated* [ERK] activity . Positive_regulation EPHB2 FGF9 11449001 835908 *induced* sustained activation of extracellular signal regulated kinase ( [ERK] ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation EPHB2 FGF9 11449001 835952 We also identify vitreous humor as an in vivo source of an FGF-like intercellular communication promoting activity and show that *induced* [ERK] activation in the intact lens is higher in the equatorial region than in polar and core fibers . Positive_regulation EPHB2 FGF9 11495895 860855 Forced expression of Sprouty2 and Sprouty4 inhibited *induced* [ERK] activation but did not affect EGF- or PDBu induced ERK activation . Positive_regulation EPHB2 FGF9 11684653 875787 Experiments with Fgf inhibitors reveal that [ERK] activation at this stage is totally *dependent* on signalling . Positive_regulation EPHB2 FGF9 12402043 1009389 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Positive_regulation EPHB2 FGF9 14973553 1212484 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 FGF9 15145928 1267555 Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires *induced* [ERK] and JNK signaling . Positive_regulation EPHB2 FGF9 16603339 1624472 We also showed that SefECTM associated with FGFR1 , and inhibited *induced* [ERK] activation in HEK293T cells . Positive_regulation EPHB2 FGF9 16831426 1586888 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Positive_regulation EPHB2 FGF9 16831426 1587483 We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of *induced* [ERK] activity . Positive_regulation EPHB2 FGF9 16857343 1672412 By repressing events upstream and/or downstream Ras , Sef inhibits *induced* [ERK] activation and cell proliferation . Positive_regulation EPHB2 FGF9 16888801 1672702 Spry2 inhibits dependent [ERK] *activation* and thus Spry acts as a feedback inhibitor of FGF mediated proliferation . Positive_regulation EPHB2 FGF9 17164422 1679088 Dusp6 ( Mkp3 ) is a negative feedback regulator of *stimulated* [ERK] signaling during mouse development . Positive_regulation EPHB2 FGF9 17368052 1760173 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an dependent *activation* of [ERK] when loaded . Positive_regulation EPHB2 FGF9 17516543 1762064 Furthermore , we demonstrate that TGF-beta1 signaling can modulate EGF and induced [ERK-MAP] kinase *activation* by controlling Spry2 expression and function . Positive_regulation EPHB2 FGF9 17852407 1817856 *induced* a transient activation of [ERK] , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation EPHB2 FGF9 18625726 1954492 These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of induced [ERK] *activation* . Positive_regulation EPHB2 FGF9 18678649 1967499 This site is functional , since its mutation enhanced the repressive function of Sprouty2 on *induced* [Erk] signaling . Positive_regulation EPHB2 FGF9 19103198 2060648 We show that *stimulates* [ERK] in DCDMLs via the canonical Ras/Raf1 pathway , and that the reason that neither basal nor growth factor stimulated GJIC is blocked by activation of ERK is because it is not mediated by Cx43 . Positive_regulation EPHB2 FGF9 19137008 2037777 Those effects were dependent on the C-terminal cysteine-rich region , but not on the N-terminal region of Sprouty4 , which is critical for the suppression of mediated [ERK] *activation* . Positive_regulation EPHB2 FGF9 21515689 2439563 The amitriptyline ( a tricyclic antidepressant ) -induced [ERK] activation was specifically and completely *inhibited* by tyrosine kinase inhibitors and siRNA for FGFR1 and -2 . Positive_regulation EPHB2 FGF9 9892010 586554 ERK ) and augments *stimulated* [ERK] activity . Positive_regulation EPHB2 FGFR1 11031252 786053 The expression of a dominant negative FGFR1 did not reduce ERK-1/2 activation by the HMW FGF-2 , suggesting that [ERK] activation does not *require* activity . Positive_regulation EPHB2 FGFR1 11850809 913013 bFGF-induces phosphorylation of and *activation* of [Ras/ERK] in ESFT cells that die when exposed to bFGF . Positive_regulation EPHB2 FGFR1 14678983 1179021 Despite extensive homology and equivalent expression by both chimeric receptors in the ventral prostate gland , only *triggers* detectable nuclear translocation of [Erk] and progression to prostatic intraepithelial neoplasia ( PIN ) . Positive_regulation EPHB2 FGFR1 16387627 1505758 We have recently discovered that release of fibroblast growth factor 2 and the subsequent activation of are *required* for maximal induction by PDGF of [ERK] and of human smooth muscle cell proliferation . Positive_regulation EPHB2 FGFR1 19047466 1999192 activation *leads* to increased phosphorylation of unstimulated [EphB2] , which we show is caused by down-regulation of the leukocyte common antigen related tyrosine phosphatase receptor that dephosphorylates EphB2 . Positive_regulation EPHB2 FGFR1 20463222 2257698 These results indicate that [MAPK/ERK] *activation* downstream of is necessary for MMCm motor axon guidance and that ES cell derived neurons provide an important tool for dissecting intracellular pathways required for axon guidance . Positive_regulation EPHB2 FGFR1 21156008 2373403 Biochemical analyses of transfected cells showed that activated increased JSAP1 's affinity for JNK and ERK and that JSAP1 *enhanced* FGFR induced JNK and [ERK] activation . Positive_regulation EPHB2 FGFR1 22247553 2564250 Whereas FGF ligand induced phosphorylation of FGFR1 preferentially activates [ERK] , FN-induced phosphorylation of preferentially *activates* AKT , indicating differential downstream signaling of FGFR1 in response to alternate stimuli . Positive_regulation EPHB2 FGFR1 8264585 246901 Activation of in transfected L6 myoblasts *induced* far stronger phosphorylation of phospholipase C gamma , SHC , and [ERK] proteins than could activation of FGFR-4 in L6 cells , and only FGFR-1 activation induced tyrosine phosphorylation of a characteristic 80-kD protein . Positive_regulation EPHB2 FGFR2 11031252 786054 The expression of a dominant negative FGFR1 did not reduce ERK-1/2 activation by the HMW FGF-2 , suggesting that [ERK] activation does not *require* activity . Positive_regulation EPHB2 FGFR2 12761878 1091729 Inhibition of protein kinase C with bisindolylmaleimide did not interfere with the effect of 1,25 ( OH ) ( 2 ) D ( 3 ) on mediated [ERK] *activation* . Positive_regulation EPHB2 FGFR2 21156008 2373404 Biochemical analyses of transfected cells showed that activated FGFR increased JSAP1 's affinity for JNK and ERK and that JSAP1 enhanced induced JNK and [ERK] *activation* . Positive_regulation EPHB2 FGFR3 11031252 786055 The expression of a dominant negative FGFR1 did not reduce ERK-1/2 activation by the HMW FGF-2 , suggesting that [ERK] activation does not *require* activity . Positive_regulation EPHB2 FGFR3 11751158 898193 Treatment with the pyrazolopyrimidine Src inhibitor PP1 ( 10 microM ) or AF-DX 116 ( 10 microM ) blocks *stimulated* [ERK] phosphorylation . Positive_regulation EPHB2 FGFR3 16283591 1518472 In isolated hearts , *caused* phosphorylation of both Akt and [ERK] . Positive_regulation EPHB2 FGFR3 19020135 1992093 Nicorandil inhibited *induced* [ERK] activation in a concentration dependent manner . Positive_regulation EPHB2 FGFR3 19221016 2050241 *induced* activation of EGFR and downstream [ERK] signaling also regulates transcriptional activation of MMP7 , thereby identifying a novel feed-forward mechanism for neoplastic cell proliferation . Positive_regulation EPHB2 FGFR3 20890030 2326901 The major pathway of the pathogenesis in achondroplasia is the suppression of PTHrP-PTHR system , which is mainly mediated by [ERK] activation *induced* by constitutive active . Positive_regulation EPHB2 FGFR3 21156008 2373405 Biochemical analyses of transfected cells showed that activated increased JSAP1 's affinity for JNK and ERK and that JSAP1 *enhanced* FGFR induced JNK and [ERK] activation . Positive_regulation EPHB2 FGFR4 11031252 786056 The expression of a dominant negative FGFR1 did not reduce ERK-1/2 activation by the HMW FGF-2 , suggesting that [ERK] activation does not *require* activity . Positive_regulation EPHB2 FGFR4 21156008 2373406 Biochemical analyses of transfected cells showed that activated FGFR increased JSAP1 's affinity for JNK and ERK and that JSAP1 enhanced induced JNK and [ERK] *activation* . Positive_regulation EPHB2 FHL2 18356303 1925344 Our findings point to a *role* of in bundling of focal adhesion structures , in integrin mediated [ERK] activation , and subsequently in proper allocation of matrix proteins on the cell surface . Positive_regulation EPHB2 FIGF 22545097 2590370 The requirement of a9ß1 for native and *stimulated* proliferation , migration and [Erk] activation was demonstrated by treating with a9ß1 blocking antibody or knock-down of a9 . Positive_regulation EPHB2 FKBP5 21508957 2428626 Dynamic [EphB2-NR1] interaction enhances NMDA receptor current , *induces* gene expression and enhances behavioural signatures of anxiety . Positive_regulation EPHB2 FLT1 11554745 859914 Although SPARC derived peptide showed an angiogenic effect , intact SPARC itself inhibited the mitogenic activity of vascular endothelial growth factor ( VEGF ) for ECs by the inhibiting phosphorylation of ( VEGF receptor 1 ) and subsequent [ERK] *activation* . Positive_regulation EPHB2 FLT4 21217783 2419634 The fungicide ciclopirox inhibits lymphatic endothelial cell tube formation by suppressing *mediated* [ERK] signaling pathway . Positive_regulation EPHB2 FLT4 24523457 2918835 Moreover , Vegfc- and *dependent* [Erk] signaling is impaired in the absence of Ccbe1 . Positive_regulation EPHB2 FN1 11294892 801192 Urokinase receptor and *regulate* the [ERK] ( MAPK ) to p38 ( MAPK ) activity ratios that determine carcinoma cell proliferation or dormancy in vivo . Positive_regulation EPHB2 FN1 11440167 833230 The performed analysis showed *stimulation* of [ERK] 's by fetal calf serum ( FCS ) or in the C3H 10T1/2 cell cultures at logarithmic phase of growth . Positive_regulation EPHB2 FN1 12458213 1037594 Although integrin reportedly regulates the transcription of the IRS-1 gene via FAK mediated JNK activation , no impairment of *stimulated* activation of FAK , [ERK] , or JNK was observed in MEKK1-deficient cells . Positive_regulation EPHB2 FN1 15694666 1371708 *stimulated* the phosphorylation of [Erk] and increased Rho protein expression . Positive_regulation EPHB2 FN1 16298629 1484834 SRL above 1 nmol/L inhibited PDGF induced VSMC proliferation and collagen synthesis but not PDGF induced secretion , cellular ROS , and *activation* of [ERK] and p38 MAPK . Positive_regulation EPHB2 FN1 19586917 2122616 Furthermore , fragment *stimulated* [ERK] activation and MMP-13 expression were indistinguishable in control and mutant femoral head explants . Positive_regulation EPHB2 FN1 20457810 2275641 We also show that is *required* for the Pref-1 mediated inhibition of adipocyte differentiation , the activation of [ERK/MAPK] , and the upregulation of Sox9 . Positive_regulation EPHB2 FN1 21953988 2512580 All the synthesized compounds proved to be excellent ligands for both integrin receptors , and a strong influence on intracellular signaling and phosphorylation pathways was demonstrated by evaluation of *induced* phosphorylation of [ERK] . Positive_regulation EPHB2 FN1 9357821 462043 The aims of this study were to investigate whether or the inflammatory cytokines interleukin-1alpha (IL-1alpha) and tumor necrosis factor-alpha (TNF-alpha) *activate* JNK , [ERK] , and AP-1 activity in HSC and induce the gene expression of the matrix metalloproteinase transin . Positive_regulation EPHB2 FNTA 15242975 1282060 in the absence of mevinolin , inhibition of *reduced* [ERK] phosphorylation and blocked chemotaxis , indicating a role for the Ras family of GTPases ( MAPK pathway ) under these conditions . Positive_regulation EPHB2 FNTA 16983658 1633613 In parallel , and MEK inhibitors *blocked* [ERK] phosphorylation and neuroprotective effect of NAC . Positive_regulation EPHB2 FNTB 15242975 1282061 in the absence of mevinolin , inhibition of *reduced* [ERK] phosphorylation and blocked chemotaxis , indicating a role for the Ras family of GTPases ( MAPK pathway ) under these conditions . Positive_regulation EPHB2 FNTB 16983658 1633614 In parallel , and MEK inhibitors *blocked* [ERK] phosphorylation and neuroprotective effect of NAC . Positive_regulation EPHB2 FOS 10454742 638359 ACTH , itself a very weak mitogen , blocks the mitogenic response effect of FGF2 in the early and middle G1 phase , keeping both [ERK-MAPK] activation and *induction* at maximal levels . Positive_regulation EPHB2 FOS 11004713 734991 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping [ERK-MAPK] activation and and cyclin D1 *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation EPHB2 FOS 11196459 762014 In G0/G1 cell cycle arrested mouse Y1 adrenocortical tumor cells ACTH39 , a weak mitogen and strong anti-mitogenic agent , blocks FGF2 mitogenic activity at G1 phase , keeping untouched [ERK-MAPK] activation and protein *induction* . Positive_regulation EPHB2 FOS 11410534 826452 Drosophila *mediates* [ERK] and JNK signals via distinct phosphorylation sites . Positive_regulation EPHB2 FOS 15005710 1217457 Cytoplasmic induced by the YXXQ derived STAT3 signal *requires* the co-operative [MEK/ERK] signal for its nuclear translocation . Positive_regulation EPHB2 FOS 15993334 1429653 Whereas inhibiting the ERK pathway with the MEK inhibitor PD98059 significantly decreased HNE mediated [ERK] phosphorylation , protein *induction* , AP-1 binding , and HO-1 protein induction , inhibition of the ERK pathway had no effect on HNE induced HO-1 mRNA . Positive_regulation EPHB2 FOS 18986987 2001363 Point mutation of either amino acids 212 ( glycine to serine ) or 366 ( serine to threonine ) from the B95.8 isoform to the tumor variant version of LMP1 was sufficient for gain of function characterized by sustained activation of [Erk] and subsequent *induction* and binding to the AP1 site . Positive_regulation EPHB2 FOS 21163924 2390732 [ERK] *activates* transcription of , part of the AP-1 transcription factor . Positive_regulation EPHB2 FOS 9537433 497549 Furthermore , in 25 of 26 cases of HCC which genomic DNA was available , 22 cases without genomic DNA amplification exhibited positive correlation , not only between protein expression of and cyclin D1 , but also between [MAPK/ERK] *activation* and cyclin D1 expression . Positive_regulation EPHB2 FOSB 18423429 1907941 The transcription factor is *induced* in neurons of the medial preoptic area ( MPOA ) during parenting , through activation of the extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 FOSL1 15389548 1304764 Like NFLC , induction of urokinase plasminogen activator (uPAR) , transin/matrix metalloproteinase 3 (MMP3) , and transforming growth factor beta 1 ( TGF beta 1 ) *required* collaborative [ERK] and JNK signaling while the increased expression of cortexin , rat collapsin response mediator protein 4 ( rCRMP4 ) , rat growth and transformation dependent protein ( RGT ) , and synapsin II required neither mitogen activated protein kinase (MAPK) pathway . Positive_regulation EPHB2 FOSL1 15528491 1355047 Furthermore , treatment of cells with GM6001 , which inhibits matrix metalloproteinase activity , significantly suppressed CS-stimulated EGF shedding , EGFR and [ERK] kinase phosphorylation , and subsequent *induction* . Positive_regulation EPHB2 FOXO1 24424889 2901243 Taken together , these findings suggest that MHY-449 induces apoptosis via downregulation of the and *activation* of [ERK] in androgen independent , p53-null and PTEN negative PC3 human prostate cancer cells . Positive_regulation EPHB2 FPR2 18174366 1883378 interaction *results* in cAMP independent [PI-3K/ERK] activation with downstream integrin up-regulation . Positive_regulation EPHB2 FRS2 14751248 1205220 More Grb2-SOS complexes were recruited to the plasma membrane by binding to membrane bound in FGF pathway than in EGF pathway and *caused* sustained activation of [ERK] . Positive_regulation EPHB2 FRS2 20652960 2322153 *regulates* [Erk] levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells . Positive_regulation EPHB2 FRS2 20652960 2322155 Quantitatively different levels of [Erk] activation *mediated* by may regulate self-renewal of NSCs and proliferation of neural stem/progenitor cells ( NSPCs ) ; Positive_regulation EPHB2 FSCN1 15537893 1336632 In the injured L5 DRG , the L5 *induced* the activation of [ERK] , p38 , and JNK in different populations of DRG neurons . Positive_regulation EPHB2 FSHR 16787538 1590903 Upon FSH stimulation , the *activates* the extracellular signal regulated kinases ( [ERK] ) . Positive_regulation EPHB2 FSHR 16787538 1590904 In the present study , we examined the ability of the FSH activated to *induce* [ERK] phosphorylation , in conditions where its beta-arrestin- and dynamin mediated internalization was impaired . Positive_regulation EPHB2 FSHR 16887887 1632401 Here , we show that the expressed in HEK 293 cells *activated* [ERK] by two temporally distinct pathways dependent , respectively , on Galpha ( s ) /PKA and beta-arrestins . Positive_regulation EPHB2 FSHR 16887887 1632416 In conclusion , we demonstrate the existence of a beta-arrestin dependent , GRK regulated mechanism for [ERK] *activation* by the . Positive_regulation EPHB2 FUT1 24091596 2874533 HMGB1 stimulation of *increased* the phosphorylation of Src and [Erk] and HMGB1 induced HSC migration was blocked by the Src inhibitor PP2 and the Erk inhibitor U0126 . Positive_regulation EPHB2 FXR1 23119029 2696070 In stably transfected human colon cancer cells , overexpression of *reduced* EGFR , [ERK] , Src phosphorylation and cell proliferation , and in nude mice attenuated the growth of human colon cancer xenografts ( 64 % reduction in tumor volume ; 47 % reduction in tumor weight ; both P < 0.01 ) . Positive_regulation EPHB2 FXR2 23119029 2696071 In stably transfected human colon cancer cells , overexpression of *reduced* EGFR , [ERK] , Src phosphorylation and cell proliferation , and in nude mice attenuated the growth of human colon cancer xenografts ( 64 % reduction in tumor volume ; 47 % reduction in tumor weight ; both P < 0.01 ) . Positive_regulation EPHB2 G3BP1 24157923 2875329 Moreover , downregulation of significantly *inhibited* the phosphorylation of Src , FAK and [ERK] , and the levels of NF-?B were also markedly decreased in H1299 cells . Positive_regulation EPHB2 GAB1 11323411 827215 To investigate the mechanism by which and SHP2 *mediate* [ERK] activation , we characterized the Gab1-SHP2 interaction . Positive_regulation EPHB2 GAB1 11323411 827227 Thus , physical association of activated SHP2 with is necessary and *sufficient* to mediate the [ERK] mitogen activated protein kinase activation . Positive_regulation EPHB2 GAB1 12008033 940728 Since [ERK] is *regulated* by the phosphorylated , these data demonstrate that BCR triggered phosphorylation and signal amplification of Gab1/2 is a critical step in a life or death decision of B cells . Positive_regulation EPHB2 GAB1 12941962 1157912 Finally , the increased phosphorylation of by Src selectively *potentiated* HGF induced activation of [ERK] and AKT . Positive_regulation EPHB2 GAB1 14973141 1235873 Increased expression *enhanced* the recruitment and activation of SHP-2 , as well as the phosphorylation of the mitogen activated protein kinases [Erk] and p38 by PDGF . Positive_regulation EPHB2 GAB1 23318428 2860729 We found that ( Grb2 associated binder 1 ) was *involved* in the mutant Shp2 mediated [Erk] activation . Positive_regulation EPHB2 GAB1 9632795 513076 These observations suggest that Gab1 acts as an adapter molecule in transmitting signals to ERK MAP kinase for the cytokine receptor gp130 and that SHP-2 , PI-3 kinase , and Ras are involved in mediated [ERK] *activation* . Positive_regulation EPHB2 GAB2 11830491 909930 Analysis of these cell lines indicated that induction of Gab2WT expression , but not expression , *led* to [Erk] activation , growth arrest , cell spreading , and enlargement ; Positive_regulation EPHB2 GAB2 12008033 940727 Since [ERK] is *regulated* by the phosphorylated , these data demonstrate that BCR triggered phosphorylation and signal amplification of Gab1/2 is a critical step in a life or death decision of B cells . Positive_regulation EPHB2 GAB2 15170389 1280325 Expression of the Gab2 Tyr-614 -- > Phe ( Y614F ) mutant , defective in SHP-2 association , prevents ERK ( extracellular-signal regulated kinase ) activation and expression of a luciferase reporter plasmid driven by the c-fos SRE ( serum response element ) , indicating that interaction of SHP-2 with is *required* for [ERK] activation in response to IL-2 . Positive_regulation EPHB2 GAB2 16705167 1560774 Tcptp-/- macrophages also have increased tyrosine phosphorylation and recruitment of a complex to the CSF-1R and enhanced *activation* of [Erk] after CSF-1 stimulation , which are important molecular events in CSF-1 induced differentiation . Positive_regulation EPHB2 GABRA1 17916335 1819276 These results demonstrated that the changes in [ERK] phosphorylation in hippocampus and PFC were *regulated* by in a learning and memory paradigm under acute restraint stress conditions . Positive_regulation EPHB2 GABRB2 17916335 1819277 These results demonstrated that the changes in [ERK] phosphorylation in hippocampus and PFC were *regulated* by in a learning and memory paradigm under acute restraint stress conditions . Positive_regulation EPHB2 GABRG2 17916335 1819278 These results demonstrated that the changes in [ERK] phosphorylation in hippocampus and PFC were *regulated* by in a learning and memory paradigm under acute restraint stress conditions . Positive_regulation EPHB2 GADD45B 15642734 1381387 Antisense inhibition of strikingly *blocked* IR-induced NF-kappaB and [ERK] but not p38 and JNK . Positive_regulation EPHB2 GADD45G 10910949 715803 In this study we have explored the involvement of oxidative stress in *induced* JNK , p38 and [ERK] signaling pathways and their effects on Cr(VI) cytotoxicity in human non-small cell lung carcinoma CL3 cells . Positive_regulation EPHB2 GADD45G 10910949 715805 Co-administering Cr(VI) with 3-amino-1,2 , 4-triazole ( 3AT ) , a catalase inhibitor , enhanced p38 activation , but did not influence JNK and [ERK] *activation* by . Positive_regulation EPHB2 GADD45G 10910949 715807 SB202190 , a specific inhibitor of p38 , markedly decreased JNK but did not change [ERK] *activation* by . Positive_regulation EPHB2 GADD45G 11678615 873670 Oppositely , *activation* of [ERK] , JNK and p38 by does not affect cytotoxicity . Positive_regulation EPHB2 GAL 10980593 731048 While phorbol ester induced extracellular signal regulated kinase ( ERK ) activation required protein kinase C ( PKC ) activity , preincubation of H69 cells with the PKC-inhibitor GF109203X had no effect on *dependent* [ERK] activity . Positive_regulation EPHB2 GAL 10980593 731049 A rise of the intracellular calcium concentration was necessary and sufficient to mediate *induced* [ERK] activation . Positive_regulation EPHB2 GAL 16819983 1581549 This study identified a novel physiological role for *induced* [ERK] phosphorylation and identified ERK and protein kinase C as important signaling components in the galanin mediated modulation of neurite outgrowth . Positive_regulation EPHB2 GAL 24011530 2902140 In addition , cryptotanshinone significantly suppressed JNK , [ERK] and p38 phosphorylation *induced* by , and phosphorylation of TAK1 as well . Positive_regulation EPHB2 GAREM 19509291 2108656 Consequently , [Erk] activation in response to EGF stimulation is *regulated* by the expression of in COS-7 and HeLa cells , which occurs independent of the presence of other binding proteins , such as Gab1 and SOS , to the activated EGF receptor . Positive_regulation EPHB2 GAREM 24003223 2851342 Furthermore , and Shp2 *regulate* [Erk] activity in EGF stimulated cells . Positive_regulation EPHB2 GAREM 24003223 2851351 Eventually , *regulates* [Erk] activation in the presence of EGF or insulin like growth factor 1 . Positive_regulation EPHB2 GAS6 10435635 634413 We further show evidence that stimulation of serum starved NIH3T3 cells *results* in a transient [ERK] , JNK/SAPK and p38 MAPK activation . Positive_regulation EPHB2 GAS6 9973250 595860 *stimulated* the extracellular signal regulated kinase , [ERK] , and the serine-threonine kinase , Akt , a downstream component of the phosphoinositide 3-kinase (PI3-K) pathway . Positive_regulation EPHB2 GAST 12891702 1117752 Also , dependent COX-2 expression did not *require* PKC activity , activation of [ERK] , or transactivation of EGFR . Positive_regulation EPHB2 GATA1 12193378 981048 Electrophoretic mobility shift assays for SF-1 and GATA revealed that PMA failed to affect SF-1 binding but enhanced binding to a consensus GATA oligonucleotide , an effect that was blocked with U0126 pretreatment , suggesting that GATA may *mediate* [ERK] activation of alphaGSU transcription . Positive_regulation EPHB2 GATA2 12193378 981049 Electrophoretic mobility shift assays for SF-1 and GATA revealed that PMA failed to affect SF-1 binding but enhanced binding to a consensus GATA oligonucleotide , an effect that was blocked with U0126 pretreatment , suggesting that GATA may *mediate* [ERK] activation of alphaGSU transcription . Positive_regulation EPHB2 GATA3 12193378 981050 Electrophoretic mobility shift assays for SF-1 and GATA revealed that PMA failed to affect SF-1 binding but enhanced binding to a consensus GATA oligonucleotide , an effect that was blocked with U0126 pretreatment , suggesting that GATA may *mediate* [ERK] activation of alphaGSU transcription . Positive_regulation EPHB2 GATA4 12193378 981051 Electrophoretic mobility shift assays for SF-1 and GATA revealed that PMA failed to affect SF-1 binding but enhanced binding to a consensus GATA oligonucleotide , an effect that was blocked with U0126 pretreatment , suggesting that GATA may *mediate* [ERK] activation of alphaGSU transcription . Positive_regulation EPHB2 GATA5 12193378 981047 Electrophoretic mobility shift assays for SF-1 and GATA revealed that PMA failed to affect SF-1 binding but enhanced binding to a consensus GATA oligonucleotide , an effect that was blocked with U0126 pretreatment , suggesting that GATA may *mediate* [ERK] activation of alphaGSU transcription . Positive_regulation EPHB2 GATA6 12193378 981052 Electrophoretic mobility shift assays for SF-1 and GATA revealed that PMA failed to affect SF-1 binding but enhanced binding to a consensus GATA oligonucleotide , an effect that was blocked with U0126 pretreatment , suggesting that GATA may *mediate* [ERK] activation of alphaGSU transcription . Positive_regulation EPHB2 GCG 14988413 1236706 We conclude that induced ERK1/2 activation is mediated by PKA and that an increase in [ Ca ( 2+ ) ] ( i ) is *required* for maximal [ERK] activation . Positive_regulation EPHB2 GDA 22977256 2688589 also *induced* phosphorylation of [ERK] in monocytes/macrophages . Positive_regulation EPHB2 GDF15 15555917 1340103 NRG-1beta effects on neurite extension and arborization are similar to , but not additive with , those of brain derived neurotrophic factor and reflect direct NRG-1 action on hippocampal neurons as these cells express the NRG-1 receptors erbB2 and erbB4 , the erbB-specific inhibitor PD158780 decreases NRG-1beta induced neurite outgrowth , and stimulation *induces* p42/44 [ERK] phosphorylation . Positive_regulation EPHB2 GDF15 17571162 1763268 *induced* activation of both [ERK] and AKT in the hearts of control mice but not in those of DKO mice . Positive_regulation EPHB2 GDNF 10995764 752373 This residual wave of Erk phosphorylation was independent of the kinase activity of c-Ret. Mutation of Tyr-1096 ( Y1096F ) , a binding site for the adaptor Grb2 , had no effect on [Erk] *activation* by . Positive_regulation EPHB2 GDNF 11351341 814812 We found that *stimulates* the phosphorylation of both the PI 3-kinase downstream substrate Akt and the MAP kinase substrate [ERK] in cultures of immunoaffinity purified embryonic avian enteric crest derived cells . Positive_regulation EPHB2 GDNF 11351341 814819 The ERK kinase ( MEK ) inhibitors PD 98059 and UO126 did not reduce GDNF stimulated proliferation , although PD 98059 blocked *stimulated* phosphorylation of [ERK] . Positive_regulation EPHB2 GDNF 16537917 1536917 We correlate the findings to intact porcine retina , where *induces* phosphorylation of [ERK] in the perinuclear region of RMG located in the inner nuclear layer . Positive_regulation EPHB2 GDNF 18154038 1838293 We reported that total levels in whole blood in patients with mood disorders were significantly lower than those in healthy control subjects ( Takebayashi et al , 2006 ) , and antidepressants *increased* GDNF production through monoamine independent activation of protein tyrosine kinase (PTK) and extracellular signal regulated kinase ( [ERK] ) in glial cells ( Hisaoka et al , 2007 ) . Positive_regulation EPHB2 GDNF 19277011 2079803 However , only nigrostriatal overexpression *induced* activation of phosphorylated extracellular signal regulated kinase ( [p-ERK] ) in a small population of corticotrophin releasing factor [corticotrophin releasing hormone (CRH) ] neurons located specifically in the medial parvocellullar division ( MPD ) of the paraventricular nucleus of the hypothalamus . Positive_regulation EPHB2 GDNF 19649251 2118949 selectively *induces* microglial activation and neuronal survival in CA1/CA3 hippocampal regions exposed to NMDA insult through [Ret/ERK] signalling . Positive_regulation EPHB2 GDNF 20615395 2309888 Treatment with *induced* [MEK/ERK] and JNK/c-Jun activation and increased AP-1 DNA binding activity in a time dependent manner . Positive_regulation EPHB2 GDNF 22971345 2697826 Genetic and pharmacologic inhibition of the receptors GFRA1 and RET abrogated the migratory effect of EMF-CM and *reduced* [ERK] phosphorylation . Positive_regulation EPHB2 GDNF 23262364 2763874 stimulation *activates* intracellular PI3K/Akt and [MEK/Erk] signaling cascades as detected by Western blot analysis of cultures prepared from rats at postnatal days 5 ( P5 , before the onset of hearing ) and 20 ( P20 , after the onset of hearing ) . Positive_regulation EPHB2 GDNF 23468876 2750147 EGR-1 siRNA also reduced *induced* [cRaf/MEK/ERK] phosphorylation by 80 % . Positive_regulation EPHB2 GDNF 24045439 2920875 Similarly , sunitinib , a small-molecule inhibitor of RET , blocked *mediated* activation of [ERK] and AKT . Positive_regulation EPHB2 GEMIN4 11244499 792314 Overexpression of p97Eps8 leads to cellular transformation : implication of pleckstrin homology domain in mediated [ERK] *activation* . Positive_regulation EPHB2 GFAP 23506591 2756952 Curcumin reduced the injury induced thermal and mechanical hyperalgesia , the increase in the fluorescence intensity of GFAP and the hypertrophy of astrocytic soma , *activation* of and phosphorylation of [ERK] in the spinal dorsal horn . Positive_regulation EPHB2 GGA1 23792203 2820540 These findings suggest that *activation* of [ERK] by reduces melanin synthesis in Mel-Ab cells through downregulation of MITF and tyrosinase expression . Positive_regulation EPHB2 GGA2 23792203 2820538 These findings suggest that *activation* of [ERK] by reduces melanin synthesis in Mel-Ab cells through downregulation of MITF and tyrosinase expression . Positive_regulation EPHB2 GGA3 21664574 2442651 Met recycling , sustained [ERK] activation , and migration *require* interaction of with Arf6 and an unexpected association with the Crk adaptor . Positive_regulation EPHB2 GGA3 23792203 2820539 These findings suggest that *activation* of [ERK] by reduces melanin synthesis in Mel-Ab cells through downregulation of MITF and tyrosinase expression . Positive_regulation EPHB2 GH1 16477370 1548473 Earlier , we demonstrated that okadaic acid ( OA ) , an inhibitor of a serine/threonine phosphatase PP2A , stimulated the *induced* [ERK] phosphorylation in the wild type Chinese hamster ovary ( CHO ) cells and the cells expressing ErbB1 receptor , but suppressed ERK activation in CHO cells that express ErbB4 receptor . Positive_regulation EPHB2 GH1 18499741 1939360 JAK2 , but not Src family kinases , is required for STAT , [ERK] , and Akt signaling in *response* to in preadipocytes and hepatoma cells . Positive_regulation EPHB2 GHRH 22307626 2552234 *induced* a significant increase in levels of [ERK] , but JMR-132 abolished this outcome . Positive_regulation EPHB2 GJA1 10792610 689331 Using two structurally unrelated PI3K inhibitors , wortmanin and LY294002 , both tyrosine phosphorylation of and *activation* of [ERK] stimulated by PDGF were largely blocked . Positive_regulation EPHB2 GJA1 22277757 2575619 The PKCd independent activation of ERK by FGF2 was confirmed by Western blotting , as was the *dependent* enhancement of [ERK] activation . Positive_regulation EPHB2 GLRX 16806262 1612733 Overexpression of likewise *inhibited* strain stimulated Ras S-glutathiolation , Ras activation , [Erk] activation and protein synthesis . Positive_regulation EPHB2 GNA13 15743761 1396820 Constitutively active Galpha(12)- or induced *activation* of JNK and p38 MAPK , but not extracellular signal regulated kinase ( [ERK] ) , was inhibited by diphenyleneiodonium . Positive_regulation EPHB2 GNA15 18406577 1899602 Differential involvement of in CC chemokine *induced* stimulation of phospholipase Cbeta , [ERK] , and chemotaxis . Positive_regulation EPHB2 GNA15 20639119 2292266 Expression of , a constitutively active mutant of Galpha16 , in HEK 293 cells *led* to the formation of GTP bound Ras and the subsequent phosphorylation of [ERK] . Positive_regulation EPHB2 GNAS 12902401 1121102 LPA induced chemotaxis is markedly dependent on activation of PTX-sensitive , on activation of the small GTPases Ras , Rac and RhoA , and on GTPase dependent *activation* of [ERK] . Positive_regulation EPHB2 GNB1 12902401 1121103 LPA induced chemotaxis is markedly dependent on activation of PTX-sensitive , on activation of the small GTPases Ras , Rac and RhoA , and on GTPase dependent *activation* of [ERK] . Positive_regulation EPHB2 GNB2L1 17149700 1687039 expression *restored* contact inhibition , stress fiber formation and reduced [ERK] phosphorylation in Ki-Ras transformed NIH 3T3 cells . Positive_regulation EPHB2 GNB2L1 17908799 1824548 We found that associated with the core kinases of the ERK pathway , Raf , MEK , and ERK , and that attenuation of RACK1 expression *resulted* in a decrease in [ERK] activity in response to adhesion but not in response to growth factors . Positive_regulation EPHB2 GNB2L1 20819076 2336434 Interaction with was also *essential* for PKC dependent and [ERK] ( extracellular-signal regulated kinase ) -independent phosphorylation ( on Ser¹²6 ) , and activation of PDE4D5 in response to PMA and isoproterenol , both of which trigger the recruitment of PKCa to RACK1 . Positive_regulation EPHB2 GNG2 12902401 1121104 LPA induced chemotaxis is markedly dependent on activation of PTX-sensitive , on activation of the small GTPases Ras , Rac and RhoA , and on GTPase dependent *activation* of [ERK] . Positive_regulation EPHB2 GNRH1 10514457 651775 These observations suggest that calcium influx through L-type channels is required for *induced* activation of [ERK] and c-Fos and that the influence of calcium lies downstream of protein kinase C . Positive_regulation EPHB2 GNRH1 10799494 691176 Therefore , although *activation* of [ERK] by requires a specific influx of calcium through L-type calcium channels , JNK activation is independent of extracellular calcium but sensitive to chelation of intracellular calcium . Positive_regulation EPHB2 GNRH1 11083862 809966 Role of dynamin , Src , and Ras in the protein kinase C-mediated *activation* of [ERK] by . Positive_regulation EPHB2 GNRH1 11083862 809970 Our results suggest that the *activation* of [ERK] by involves two distinct signaling pathways , which converge at the level of Raf-1 . Positive_regulation EPHB2 GNRH1 11165042 782727 One mechanism requires *induced* [ERK] and JNK activation , while a second MAPK independent pathway requires a thapsigargin-sensitive calcium signal . Positive_regulation EPHB2 GNRH1 11399487 824107 However , chronic exposure to TPA resulted in reduction of basal and *induced* [ERK] elevation . Positive_regulation EPHB2 GNRH1 11399487 824212 This inhibitor completely blocked *induced* increases in [ERK] activity . Positive_regulation EPHB2 GNRH1 11750725 889863 *Activation* of [ERK] -- one of the MAPK cascades -- by in these cells depends mainly on the phosphorylation of Raf1 by PKC , supported by a pathway involving c-Src , dynamin , and Ras . Positive_regulation EPHB2 GNRH1 11875099 918856 In this paper , we demonstrate that *activates* [ERK] , c-Jun N-terminal kinase , and p38MAPK in the LbetaT2 gonadotrope cell line . Positive_regulation EPHB2 GNRH1 11875099 918869 Phosphorylation of both ERK and p38MAPK are stimulated rapidly , 30- to 50-fold in 5 min , but activation of c-Jun N-terminal kinase has slower kinetics , reaching only 10-fold after 30 min. *Activation* of [ERK] by is blocked by inhibition of MAPK kinase ( MEK ) and partially blocked by inhibition of PKC and calcium , but not PI3K or p38MAPK signaling . Positive_regulation EPHB2 GNRH1 12297539 991379 *activated* [ERK] , but PACAP did not , and the activation was not inhibited by quinpirol . Positive_regulation EPHB2 GNRH1 12538624 1050197 Surprisingly , although c-Src is involved in *stimulated* [ERK] , its involvement is mapped to another region ( -280/-180 ) containing the glycoprotein-specific element . Positive_regulation EPHB2 GNRH1 12586760 1059369 Neither overexpression of a constitutively active Raf-kinase nor pharmacological blockade of *induced* [ERK] activation eliminated the GnRH response of the GnRHR promoter . Positive_regulation EPHB2 GNRH1 12750372 1119624 c-Src is activated by the epidermal growth factor receptor in a pathway that mediates JNK and [ERK] *activation* by in COS7 cells . Positive_regulation EPHB2 GNRH1 12963732 1164296 We found that *induced* Src , Ras , and [ERK] activation were also gelatinase dependent . Positive_regulation EPHB2 GNRH1 14736735 1226063 [ERK] *activation* by is dependent on protein kinase C ( PKC ) , as evident by activation , inhibition , and depletion of 12-O-tetradecanoylphorbol-13-acetate-sensitive PKC subspecies . Positive_regulation EPHB2 GNRH1 14736735 1226070 [ERK] *activation* by in LbetaT-2 cells does not involve transactivation of epidermal growth factor receptor or mediation via Gbetagamma or beta-arrestin . Positive_regulation EPHB2 GNRH1 14752057 1235053 Based on these findings , we conclude that acute stimulation of LbetaT2 cells *increases* translation initiation through [ERK] signaling . Positive_regulation EPHB2 GNRH1 15509729 1374769 In contrast , both and T *stimulated* threefold increases in [ERK] activity , with additive effects seen following the combination of GnRH+T. E2 had no effect on ERK activity . Positive_regulation EPHB2 GNRH1 15890671 1445578 Our previous studies demonstrate that *induced* [ERK] activation required influx of extracellular Ca2+ in alphaT3-1 and rat pituitary cells . Positive_regulation EPHB2 GNRH1 15890671 1445581 Inhibition of Cam ( using a dominant negative ) was sufficient to block *induced* [ERK] but not c-Jun N-terminal kinase activity activation . Positive_regulation EPHB2 GNRH1 15961508 1458850 GnRH induced the alpha-subunit promoter-luciferase reporter approximately 16-fold , and this induction was completely abolished with mutations in the dual cAMP response elements ( CREs ) or the combined inhibition of *induced* [ERK] and c-Jun N-terminal kinase . Positive_regulation EPHB2 GNRH1 16141398 1482385 In contrast , stimulation with continuous ( 10 nM ) in perifused cells *resulted* in a more sustained activation of [ERK] . Positive_regulation EPHB2 GNRH1 16314413 1511272 Arrestin mediated [ERK] *activation* by receptors : receptor-specific activation mechanisms and compartmentalization . Positive_regulation EPHB2 GNRH1 16461925 1522771 Elevated activity of MKP-2 in alphaT3-1 cells , through either overexpression or activation of the endogenous MKP-2 gene , was correlated with inhibition of *induced* activation of [ERK] and JNK , as well as the expression of ERK- and JNK dependent proto-oncogenes . Positive_regulation EPHB2 GNRH1 17218416 1709704 disruption of actin with jasplakinolide abrogated cell movement and *induced* activation of [ERK] . Positive_regulation EPHB2 GNRH1 18635666 1966659 Calcium influx through L-type voltage gated calcium channels ( VGCC ) is required for [ERK] activation *induced* by in pituitary gonadotropes . Positive_regulation EPHB2 GNRH1 18635666 1966660 Knockdown of Pyk2 using specific small interfering RNAs revealed that Pyk2 contributed to modulation of *induced* [ERK] but not c-Jun N-terminal kinase activation . Positive_regulation EPHB2 GNRH1 18801931 1981184 We show that in Galpha ( q/11 ) -negative cells stably expressing the GnRH receptor , did not *induce* activation of [ERK] , jun-N-terminal kinase , or P38 MAPK . Positive_regulation EPHB2 GNRH1 18801931 1981211 In contrast to Galpha ( i ) or chimeric Galpha ( qi5 ) , transfection of Galpha ( q ) cDNA enabled to *induce* phosphorylation of [ERK] , jun-N-terminal kinase , and P38 . Positive_regulation EPHB2 GNRH1 19179479 2049168 In HeLa cells , *causes* transient and protein kinase C ( PKC ) -dependent [ERK] activation , but termination mechanisms are unknown . Positive_regulation EPHB2 GNRH1 19628583 2149919 A preformed signaling complex mediates *activated* [ERK] phosphorylation of paxillin and FAK at focal adhesions in L beta T2 gonadotrope cells . Positive_regulation EPHB2 GNRH1 19808777 2164171 Western blotting showed that *stimulated* phosphorylation of [ERK] ( phospho-ERK-1/2 ) , and this effect was abolished by RFRP-3 . Positive_regulation EPHB2 GNRH1 20392830 2262137 PGF ( 2alpha ) , PGI ( 2 ) , or PGE ( 2 ) had no effect on *stimulated* [ERK] , c-Jun N-terminal kinase , and p38MAPK activation or on GnRH- and high K ( + ) -stimulated intracellular Ca ( 2+ ) elevation in LbetaT2 and gonadotropes in primary culture . Positive_regulation EPHB2 GNRH1 20553777 2302272 The combination treatment with GnRH and PACAP did not augment the [ERK] phosphorylation *induced* by alone . Positive_regulation EPHB2 GNRH1 21436256 2432287 Results obtained by cellular fractionation/Western blot analysis and immunohistochemistry revealed that *induced* accumulation of phosphorylated [ERK] in the nucleus was attenuated when PEA-15 expression was reduced . Positive_regulation EPHB2 GNRH1 21436256 2432288 Our data suggest that *induced* nuclear translocation of [ERK] requires its release from PEA-15 , which occurs upon PEA-15 phosphorylation by PKC . Positive_regulation EPHB2 GNRH1 21541969 2423923 EGF receptor activation inhibited *induced* [ERK] activation in WPE-1-NB26 but growth-inhibition was not rescued by EGF or PKC inhibitor Ro320432 . Positive_regulation EPHB2 GNRH1 21846488 2521787 Thus , the difference between BMP-6 and BMP-7 in enhancing GnRH induced FSHß transcription may be due to the differential effects of BMP ligands on *induced* [ERK] signaling . Positive_regulation EPHB2 GNRH1 21898395 2554621 AG1478 , a relatively specific inhibitor of the ErbB family , and small interfering RNA ( siRNA ) for ErbB4 inhibited the *induced* activation of [ERK] in GT1-7 cells , suggesting that EGFR and ErbB4 were necessary for the activation . Positive_regulation EPHB2 GNRH1 22107955 2534878 The effect of on Glut1 mRNA expression is partly *mediated* by [ERK] activation . Positive_regulation EPHB2 GNRH1 22374973 2581748 We further showed that mRFRP inhibited *stimulated* [ERK] phosphorylation , and this effect was mediated by the inhibition of the protein kinase A pathway . Positive_regulation EPHB2 GNRH1 23518923 2777217 also *stimulated* c-Jun N-terminal kinase (JNK) and [ERK] activation , whereas insulin alone stimulated Akt . Positive_regulation EPHB2 GNRH2 11083862 809967 Role of dynamin , Src , and Ras in the protein kinase C-mediated *activation* of [ERK] by . Positive_regulation EPHB2 GNRH2 12750372 1119625 c-Src is activated by the epidermal growth factor receptor in a pathway that mediates JNK and [ERK] *activation* by in COS7 cells . Positive_regulation EPHB2 GNRH2 16314413 1511273 Arrestin mediated [ERK] *activation* by receptors : receptor-specific activation mechanisms and compartmentalization . Positive_regulation EPHB2 GNRHR 12750372 1119627 [ERK] *activation* by is mediated by the EGF receptor , which activates Ras either directly or via c-Src . Positive_regulation EPHB2 GNRHR 18801931 1981213 We therefore provide direct evidence , in multiple cellular backgrounds , that coupling of the to Galpha ( q/11 ) , but not to Galpha ( i/o ) or Galpha ( s ) , and consequent *activation* of [ERK] plays a crucial role in GnRH mediated cell death . Positive_regulation EPHB2 GP1BA 11776327 890641 Thus , in addition to alphavbeta3 , EC *initiates* [ERK] activation , and regulates ERK induced EC migration on vWF . Positive_regulation EPHB2 GPC1 15367691 1294845 Overexpressing Gpc-4 but not Gpc-3 or *led* to sustained HGF stimulated [ERK] activation and rescued the tubulogenic response in these cells . Positive_regulation EPHB2 GPC3 15367691 1294846 Overexpressing Gpc-4 but not or Gpc-1 *led* to sustained HGF stimulated [ERK] activation and rescued the tubulogenic response in these cells . Positive_regulation EPHB2 GPC4 15367691 1294847 Overexpressing but not Gpc-3 or Gpc-1 *led* to sustained HGF stimulated [ERK] activation and rescued the tubulogenic response in these cells . Positive_regulation EPHB2 GPER1 17900862 1811335 The stearoylated Val12-Ser49 <38-mer> peptide *enhanced* the isoprenaline stimulated PKA phosphorylation of the beta ( 2 ) -adrenergic receptors ( beta ( 2 ) AR ) and its activation of [ERK] , whilst the Glu27Ala peptide was ineffective in both these regards . Positive_regulation EPHB2 GPER1 22251451 2668243 Moreover , was *required* for epidermal growth factor receptor (EGFR) and [ERK] activation by EGF as ascertained by using MIBE and performing gene silencing experiments . Positive_regulation EPHB2 GPER1 22306083 2570966 In fact , in GC-2 cells we observed that ESR1 and activation *caused* rapid [ERK] and c-Jun phosphorylation , bax up-regulation , events associated with apoptosis . Positive_regulation EPHB2 GPER1 24379833 2883493 Here , employing ERa negative Hec50 endometrial cancer cells , we demonstrate that *mediates* estrogen stimulated activation of [ERK] and PI3K via matrix metalloproteinase activation and subsequent transactivation of the EGFR and that ER-targeted therapeutic agents ( 4-hydroxytamoxifen , ICI182,780/fulvestrant , and Raloxifene ) , the phytoestrogen genistein , and the `` ERa-selective '' agonist propylpyrazole triol also function as GPER agonists . Positive_regulation EPHB2 GPI 23394468 2920595 Finally , we proposed a possible hypothesis for the mechanism of NLK in the growth and survival of SC-induced neurons based on Western blotting results , which is that secreted by SCs *activates* the [Ras/Raf/MEK/Erk] , Jak/Stat , and PI3K/Akt pathways , but not the NF-?B pathway , in neurons resulting in their growth and survival . Positive_regulation EPHB2 GPR1 21769916 2494909 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR1 9915820 587312 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR1 9933031 589256 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR101 21769916 2494865 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR101 9915820 587268 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR101 9933031 589212 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR107 21769916 2494870 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR107 9915820 587273 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR107 9933031 589217 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR108 21769916 2494869 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR108 9915820 587272 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR108 9933031 589216 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR110 21769916 2494875 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR110 9915820 587278 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR110 9933031 589222 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR111 21769916 2494876 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR111 9915820 587279 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR111 9933031 589223 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR112 21769916 2494877 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR112 9915820 587280 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR112 9933031 589224 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR113 21769916 2494874 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR113 9915820 587277 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR113 9933031 589221 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR114 21769916 2494878 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR114 9915820 587281 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR114 9933031 589225 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR115 21769916 2494879 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR115 9915820 587282 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR115 9933031 589226 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR116 21769916 2494880 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR116 9915820 587283 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR116 9933031 589227 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR119 21769916 2494881 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR119 9915820 587284 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR119 9933031 589228 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR12 21769916 2494910 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR12 9915820 587313 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR12 9933031 589257 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR123 21769916 2494862 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR123 9915820 587265 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR123 9933031 589209 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR124 21769916 2494871 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR124 9915820 587274 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR124 9933031 589218 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR125 21769916 2494863 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR125 9915820 587266 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR125 9933031 589210 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR126 21769916 2494864 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR126 9915820 587267 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR126 9933031 589211 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR128 21769916 2494882 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR128 9915820 587285 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR128 9933031 589229 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR132 21769916 2494868 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR132 9915820 587271 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR132 9933031 589215 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR133 21769916 2494883 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR133 9915820 587286 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR133 9933031 589230 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR135 21769916 2494884 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR135 9915820 587287 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR135 9933031 589231 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR137 21769916 2494902 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR137 9915820 587305 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR137 9933031 589249 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR139 21769916 2494885 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR139 9915820 587288 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR139 9933031 589232 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR141 21769916 2494886 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR141 9915820 587289 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR141 9933031 589233 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR142 21769916 2494887 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR142 9915820 587290 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR142 9933031 589234 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR143 21769916 2494888 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR143 9915820 587291 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR143 9933031 589235 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR144 21769916 2494873 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR144 9915820 587276 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR144 9933031 589220 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR146 21769916 2494890 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR146 9915820 587293 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR146 9933031 589237 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR148 21769916 2494894 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR148 9915820 587297 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR148 9933031 589241 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR149 21769916 2494896 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR149 9915820 587299 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR149 9933031 589243 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR15 21769916 2494911 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR15 9915820 587314 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR15 9933031 589258 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR150 21769916 2494897 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR150 9915820 587300 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR150 9933031 589244 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR151 21769916 2494895 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR151 9915820 587298 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR151 9933031 589242 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR152 21769916 2494893 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR152 9915820 587296 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR152 9933031 589240 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR153 21769916 2494892 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR153 9915820 587295 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR153 9933031 589239 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR155 21769916 2494891 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR155 9915820 587294 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR155 9933031 589238 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR156 21769916 2494889 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR156 9915820 587292 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR156 9933031 589236 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR157 21769916 2494898 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR157 9915820 587301 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR157 9933031 589245 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR158 21769916 2494899 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR158 9915820 587302 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR158 9933031 589246 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR160 21769916 2494900 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR160 9915820 587303 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR160 9933031 589247 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR161 21769916 2494901 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR161 9915820 587304 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR161 9933031 589248 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR162 21769916 2494866 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR162 9915820 587269 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR162 9933031 589213 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR17 21769916 2494912 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR17 9915820 587315 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR17 9933031 589259 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR171 21769916 2494904 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR171 9915820 587307 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR171 9933031 589251 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR173 21769916 2494872 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR173 9915820 587275 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR173 9933031 589219 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR174 21769916 2494905 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR174 9915820 587308 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR174 9933031 589252 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR176 21769916 2494908 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR176 9915820 587311 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR176 9933031 589255 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR179 21769916 2494907 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR179 9915820 587310 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR179 9933031 589254 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR18 21769916 2494913 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR18 9915820 587316 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR18 9933031 589260 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR180 21769916 2494903 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR180 9915820 587306 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR180 9933031 589250 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR182 21769916 2494860 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR182 9915820 587263 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR182 9933031 589207 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR183 21769916 2494906 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR183 9915820 587309 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR183 9933031 589253 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR19 21769916 2494914 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR19 9915820 587317 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR19 9933031 589261 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR20 21769916 2494915 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR20 9915820 587318 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR20 9933031 589262 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR21 21769916 2494916 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR21 9915820 587319 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR21 9933031 589263 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR22 21769916 2494917 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR22 9915820 587320 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR22 9933031 589264 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR25 21769916 2494918 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR25 9915820 587321 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR25 9933031 589265 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR26 21769916 2494919 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR26 9915820 587322 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR26 9933031 589266 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR27 21769916 2494920 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR27 9915820 587323 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR27 9933031 589267 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR3 21769916 2494921 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR3 9915820 587324 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR3 9933031 589268 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR31 21769916 2494922 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR31 9915820 587325 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR31 9933031 589269 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR32 21769916 2494923 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR32 9915820 587326 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR32 9933031 589270 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR33 21769916 2494924 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR33 9915820 587327 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR33 9933031 589271 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR34 21769916 2494925 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR34 22058210 2540433 Although functional consequences of t ( X ; 14 ) have not been identified , our studies suggest that up-regulated *activate* neither nuclear factor-?B nor [ELK related tyrosine kinase] . Positive_regulation EPHB2 GPR34 9915820 587328 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR34 9933031 589272 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR35 21769916 2494926 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR35 9915820 587329 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR35 9933031 589273 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR36 21769916 2494927 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR36 9915820 587330 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR36 9933031 589274 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR37 21769916 2494928 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR37 9915820 587331 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR37 9933031 589275 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR39 21769916 2494929 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR39 9915820 587332 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR39 9933031 589276 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR4 21769916 2494930 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR4 9915820 587333 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR4 9933031 589277 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR42 21769916 2494931 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR42 9915820 587334 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR42 9933031 589278 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR45 21769916 2494932 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR45 9915820 587335 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR45 9933031 589279 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR50 21769916 2494933 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR50 9915820 587336 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR50 9933031 589280 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR52 21769916 2494934 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR52 9915820 587337 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR52 9933031 589281 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR55 21769916 2494935 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR55 9915820 587338 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR55 9933031 589282 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR56 21769916 2494936 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR56 9915820 587339 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR56 9933031 589283 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR6 21769916 2494937 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR6 9915820 587340 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR6 9933031 589284 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR61 21769916 2494857 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR61 9915820 587260 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR61 9933031 589204 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR62 21769916 2494858 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR62 9915820 587261 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR62 9933031 589205 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR63 21769916 2494859 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR63 9915820 587262 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR63 9933031 589206 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR64 21769916 2494938 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR64 9915820 587341 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR64 9933031 589285 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR65 21769916 2494939 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR65 9915820 587342 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR65 9933031 589286 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR68 21769916 2494940 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR68 9915820 587343 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR68 9933031 589287 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR75 21769916 2494942 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR75 9915820 587345 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR75 9933031 589289 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR78 21769916 2494943 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR78 9915820 587346 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR78 9933031 589290 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR79 21769916 2494944 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR79 9915820 587347 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR79 9933031 589291 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR82 21769916 2494945 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR82 9915820 587348 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR82 9933031 589292 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR83 21769916 2494941 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR83 9915820 587344 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR83 9933031 589288 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR84 21769916 2494946 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR84 9915820 587349 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR84 9933031 589293 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR85 21769916 2494947 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR85 9915820 587350 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR85 9933031 589294 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR87 21769916 2494948 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR87 9915820 587351 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR87 9933031 589295 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR88 21769916 2494949 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR88 9915820 587352 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR88 9933031 589296 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR97 21769916 2494861 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR97 9915820 587264 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR97 9933031 589208 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPR98 21769916 2494867 A inhibitor , pertussis toxin , and S1P(1) and S1P(3) receptor antagonists ( VPC23019 and CAY10444 ) also *inhibited* [ERK] activation . Positive_regulation EPHB2 GPR98 9915820 587270 These results demonstrate for the first time that apart from [ERK] , p38 *activation* by a can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GPR98 9933031 589214 Additional experiments indicated that tyrosine phosphorylation by a cytosolic tyrosine kinase may represent a general mechanism for *mediated* [ERK] activation . Positive_regulation EPHB2 GPX1 23007029 2706376 overexpression *causes* aberrant [ERK] activation in neonatal mouse cortex after hypoxic preconditioning . Positive_regulation EPHB2 GPX2 23007029 2706377 overexpression *causes* aberrant [ERK] activation in neonatal mouse cortex after hypoxic preconditioning . Positive_regulation EPHB2 GPX3 23007029 2706378 overexpression *causes* aberrant [ERK] activation in neonatal mouse cortex after hypoxic preconditioning . Positive_regulation EPHB2 GPX4 23007029 2706379 overexpression *causes* aberrant [ERK] activation in neonatal mouse cortex after hypoxic preconditioning . Positive_regulation EPHB2 GPX5 23007029 2706380 overexpression *causes* aberrant [ERK] activation in neonatal mouse cortex after hypoxic preconditioning . Positive_regulation EPHB2 GPX6 23007029 2706381 overexpression *causes* aberrant [ERK] activation in neonatal mouse cortex after hypoxic preconditioning . Positive_regulation EPHB2 GPX7 23007029 2706382 overexpression *causes* aberrant [ERK] activation in neonatal mouse cortex after hypoxic preconditioning . Positive_regulation EPHB2 GPX8 23007029 2706375 overexpression *causes* aberrant [ERK] activation in neonatal mouse cortex after hypoxic preconditioning . Positive_regulation EPHB2 GRAP2 10628325 576334 The inhibitor , PD169316 , *reduced* the activities of [ERK] and Akt . Positive_regulation EPHB2 GRAP2 10629859 576454 In contrast with H2O2 induced activation of ERK , the activation of [ERK] induced by phorbol ester PMA and the *activation* of JNK and induced by H2O2 were not affected by expression of GRK2-ct , indicating that the activation of ERK but not JNK and p38 is dependent on beta gamma subunit . Positive_regulation EPHB2 GRAP2 11350959 827759 Interestingly , Akt activation by UVB was attenuated by treatment with PD 98059 , a specific mitogen activated protein kinase/extracellular signal regulated protein kinase ( [Erk] ) kinase 1 *inhibitor* , or SB 202190 , a specific kinase inhibitor . Positive_regulation EPHB2 GRAP2 11360180 816756 These data are consistent with a model where thrombin *induces* [ERK] activation via both PKC dependent and independent pathways , whereas MAPK activation requires only PTKs . Positive_regulation EPHB2 GRAP2 12670923 1076213 Modulation of ERK/p38 activity ratio by multiple pharmacological and genetic interventions confirms that high ERK/p38 ratio favors tumor growth , whereas high p38/ERK ratio induces tumor growth arrest ( dormancy ) in vivo and that [ERK] is negatively *regulated* by . Positive_regulation EPHB2 GRAP2 14998726 1216712 Furthermore , we found that PD98059 , an [ERK] pathway *inhibitor* , and SB203580 , a MAPK inhibitor , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation EPHB2 GRAP2 15169879 1253540 This regulatory event is dependent upon the downstream activation of Ras and *requires* the activation of , JNK , and [ERK] mitogen activated protein kinases . Positive_regulation EPHB2 GRAP2 15310753 1333337 bFGF induced sustained activation of [ERK] and transient *activation* of ( MAPK ) , which was not associated with cell death . Positive_regulation EPHB2 GRAP2 16033772 1473515 SB203580 , a specific inhibitor of and PD98059 , a specific *inhibitor* of [ERK] , abolished sulforaphane induced MT protein expression , whereas SP600125 , a specific inhibitor of JNK , had no significant effect . Positive_regulation EPHB2 GRAP2 16109412 1448475 While extracellular signal regulated kinase ( ERK ) and activation was detected in Prx II ( -/- ) MEF , [ERK] and c-Jun N-terminal kinase (JNK) activation was *detected* in Prx II ( -/- ) skin . Positive_regulation EPHB2 GRAP2 19191907 2127881 The studies with pharmacological inhibitors suggest that calpain inhibition mediated monocyte migration is *mediated* by activation of [ERK] , , JNK , PI3K/Akt and Rac . Positive_regulation EPHB2 GRAP2 19429670 2106901 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either [ERK] *inhibitor* , inhibitor or NF-kappaB inhibitor . Positive_regulation EPHB2 GRAP2 19778233 2141050 The induction of TNF-alpha and TGF-beta1 by silica was suppressed by Src inhibitor ( PP1 ) , [ERK] *inhibitor* ( PD98059 ) , but not by kinase inhibitor ( SB203580 ) . Positive_regulation EPHB2 GRAP2 20188673 2216165 Conversely , depletion of MAP kinase activity *suppresses* EGF receptor signaling and downstream [Erk] MAP kinase signaling , as well as autocrine EGF receptor dependent proliferation . Positive_regulation EPHB2 GRAP2 21833842 2500549 This effect was accompanied by increased activation of and by decreased *activation* of extracellular signal regulated kinase ( [ERK] ) as well as activation of c-Jun NH ( 2 ) -terminal kinase ( JNK ) . Positive_regulation EPHB2 GRAP2 22493291 2601760 Exposure of DRG neurons to NMU markedly *induced* the phosphorylation of [ERK] ( p-ERK ) , whereas p-JNK or was not affected . Positive_regulation EPHB2 GRAP2 22742515 2670193 In contrast , saturated fatty acid exposure caused insulin resistance , reducing PI3K ( phosphoinositide 3-kinase ) and [ERK] ( extracellular-signal regulated kinase ) *activation* while increasing activation of stress kinases JNK ( c-Jun N-terminal kinase ) and . Positive_regulation EPHB2 GRAP2 23877364 2854508 We subsequently used JNK inhibitor , inhibitor , and [ERK] *inhibitor* to block the downstream MAPK pathways of TLR4 in macrophages , and found that LPS induced CSE expression and H2S synthesizing activity were inhibited by pretreatment with the p38 inhibitor . Positive_regulation EPHB2 GRAP2 9366464 463317 Transient experiments in COS cells revealed potent stimulation of [ERK] by mu and delta receptor activation , weak stimulation of stress activated protein kinase by all receptor types , and no *activation* of . Positive_regulation EPHB2 GRAP2 9850168 554300 IgG-SA stimulated a maximal ERK activity at 30 min , whereas activity was maximal at 5 min. Beta-glucan *stimulated* maximal [ERK] activity at 5 min and maximal p38 activity at 2 min. Non opsonized bacteria were ingested at 10 % of the level of S-SA and stimulated a minimal increase in ERK and p38 activity at 60 min. S-SA stimulation of ERK was inhibited by wortmannin , LY294002 , and genistein , but not calphostin C ; Positive_regulation EPHB2 GRAP2 9915820 587353 These results demonstrate for the first time that apart from [ERK] , *activation* by a G protein coupled receptor can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation EPHB2 GRB10 17535812 1767259 Because total Raf-1 , [ERK] , and Akt kinase activities are not *impaired* in the absence of , we propose that this adapter protein creates a subpopulation of Raf-1 with specific anti-apoptotic activity . Positive_regulation EPHB2 GRB2 10330169 614173 The paradigm for *activation* of Ras and extracellular signal regulated kinase ( [ERK] ) /mitogen activated protein (MAP) kinase by extracellular stimuli via tyrosine kinases , Shc , , and Sos does not encompass an obvious role for phosphoinositide (PI) 3-kinase , and yet inhibitors of this lipid kinase family have been shown to block the ERK/MAP kinase signalling pathway under certain circumstances . Positive_regulation EPHB2 GRB2 10400627 628254 These findings strongly support distinct *roles* for and Shc in controlling [ERK] and JNK activation after EGF stimulation . Positive_regulation EPHB2 GRB2 10976990 729632 In contrast to their implication in epidermal growth factor (EGF) receptor tyrosine kinase signaling , the adaptor protein Shc , the complex , and the small G protein Ras were not *involved* in the activation of [Erk] induced by either LPA or PGF2alpha in MC3T3-E1 cells , suggesting that activation of Erk by Gi and Gq protein coupled receptors is Ras independent in these cells . Positive_regulation EPHB2 GRB2 11418135 830197 Biochemical analyses correlated [Erk] *activation* by with its stimulation of cell cycle progression . Positive_regulation EPHB2 GRB2 11791173 901781 Here we determined the efficacy of Shc and N-Shc toward Erk activation in NGF treated PC12 cells , and found that N-Shc transduced dependent [Erk] *activation* less efficiently than Shc . Positive_regulation EPHB2 GRB2 14576154 1199911 In this present study using the small interfering RNA technique , we have found that ShcA adapter proteins play a rather active role in CSR induced Erk activation , contrary to their mostly redundant role in other signaling pathways , e.g. growth factor induced Erk activation , where can bind directly to the receptor tyrosine kinase and *activate* [Erk] in the absence of ShcA . Positive_regulation EPHB2 GRB2 16705167 1560775 Tcptp-/- macrophages also have increased tyrosine phosphorylation and recruitment of a complex to the CSF-1R and enhanced *activation* of [Erk] after CSF-1 stimulation , which are important molecular events in CSF-1 induced differentiation . Positive_regulation EPHB2 GRB2 17202467 1681073 These results suggest that DISC1 is *required* for NT-3 induced axon elongation and [ERK] activation at the distal part of axons by recruiting to axonal tips . Positive_regulation EPHB2 GRB2 8524249 335105 These results suggest that both Crk and may *contribute* to the activation of [Erk] by oncogenic Abl , whereas Nck is unlikely to participate in this pathway . Positive_regulation EPHB2 GRB2 9710602 526845 The arsenite induced tyrosine phosphorylation of Shc , enhancement of Shc and interactions , and *activation* of [ERK] were all drastically reduced by treatment of cells with either the general growth factor receptor poison suramin or the EGFR-selective inhibitor tyrphostin AG1478 . Positive_regulation EPHB2 GRB2 9763608 537170 Here we demonstrate that the BCR induced [ERK] activation is *reduced* by loss of or expression of a dominant negative form of Ras , RasN17 , whereas this response is not affected by loss of Shc . Positive_regulation EPHB2 GRIN2A 15924861 1414116 Differential *roles* of and NR2B containing NMDA receptors in [Ras-ERK] signaling and AMPA receptor trafficking . Positive_regulation EPHB2 GRIN2A 20661302 2298070 This study demonstrates that , but not NR2B , containing NMDA receptors *induce* LTP in pyramidal neurons of the CA1 hippocampus from 1 month old mice through Ras-GRF2 and [Erk] . Positive_regulation EPHB2 GRIN2A 21653857 2442145 Accordingly , primary hippocampal cultures of IQGAP1 ( -/- ) neurons exhibited reduced surface expression of NR2A and disrupted [ERK] signaling in *response* to dependent NMDAR stimulation . Positive_regulation EPHB2 GRIN2A 22366650 2576831 and NR2B containing NMDARs differentially *mediated* acute changes in cytosolic calcium , alterations in mitochondrial morphology , and phosphorylation of the MAPKs [ERK] and JNK . Positive_regulation EPHB2 GRIN2B 20661302 2298071 This study demonstrates that NR2A- , but not , containing NMDA receptors *induce* LTP in pyramidal neurons of the CA1 hippocampus from 1 month old mice through Ras-GRF2 and [Erk] . Positive_regulation EPHB2 GRK5 16887887 1632414 ( GRK5 ) and GRK6 were *required* for beta-arrestin dependent [ERK] activation by both the wild-type and 5A FSH-R . Positive_regulation EPHB2 GRK6 16887887 1632415 G protein coupled receptor kinase 5 ( GRK5 ) and were *required* for beta-arrestin dependent [ERK] activation by both the wild-type and 5A FSH-R . Positive_regulation EPHB2 GRM1 10336676 615568 Furthermore , mediated [ERK] *activation* was suppressed by the depletion of endogenous protein kinase C ( PKC ) activity and by the PKC inhibitors staurosporine and calphostin C , but not chelerythrine . Positive_regulation EPHB2 GRM1 24045944 2862744 Substitutions of critical residues in the motif reduce mGluR1 association with lipid rafts and agonist induced , dependent *activation* of extracellular-signal activated kinase1/2 MAP kinase ( [ERK-MAPK] ) . Positive_regulation EPHB2 GRM2 10336676 615569 In these cells , the phosphatidylinositol 3 kinase (PI3K) inhibitor wortmannin produced a significant , albeit only partial , inhibition of mediated [ERK] *activation* . Positive_regulation EPHB2 GRM5 15574735 1344633 This was demonstrated by the findings that the synergistic phosphorylation of [ERK] *induced* by coactivation of NMDA receptors and was blocked by either a Tat peptide that disrupts NMDA receptor/PSD-95 binding or small interfering RNAs that selectively reduce cellular levels of Homer1b/c . Positive_regulation EPHB2 GRM5 21248136 2380019 Mitochondrial reactive oxygen species are activated by through IP3 and *activate* [ERK] and PKA to increase excitability of amygdala neurons and pain behavior . Positive_regulation EPHB2 GRPR 15361544 1334169 In this study , we demonstrate that ( GRPr ) *regulates* [ERK] through multiple pathways in a single cell type depending upon receptor expression and agonist concentration . Positive_regulation EPHB2 GRPR 15361544 1334171 Furthermore , a GRPr expressing human duodenal cancer cell line showed differential sensitivity to GF 109203X throughout BN-induced ERK activation , indicating that may *activate* [ERK] via multiple pathways in cells expressing endogenous GRPr . Positive_regulation EPHB2 GSK3A 17855351 1818101 Adenovirus mediated overexpression of , but not GSK-3beta , *inhibited* [ERK] in cultured cardiac myocytes . Positive_regulation EPHB2 GSPT1 15781236 1385456 The results indicate that the up-regulation of caveolin-2 in response to insulin activates the downstream signal cascades in the cell cycle , chiefly the increased phosphorylation of [ERK] , the nuclear translocation of phosphorylated ERK , and the subsequent *activation* of of the cell cycle . Positive_regulation EPHB2 GSPT2 15781236 1385457 The results indicate that the up-regulation of caveolin-2 in response to insulin activates the downstream signal cascades in the cell cycle , chiefly the increased phosphorylation of [ERK] , the nuclear translocation of phosphorylated ERK , and the subsequent *activation* of of the cell cycle . Positive_regulation EPHB2 HADHB 11901221 921909 Although ERK activation through TPalpha was dependent on 2- [ 1- ( dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF 109203X ) -sensitive protein kinase ( PK ) Cs , [ERK] *activation* through was only partially dependent on PKCs . Positive_regulation EPHB2 HADHB 11901221 921911 [ERK] *activation* through both TPalpha and was dependent on PKA and phosphoinositide 3-kinase (PI3K) class 1 ( A ) , but not class 1 ( B ) , and was modulated by Harvey-Ras , A-Raf , c-Raf , and Rap1B/B-Raf and also involved transactivation of the epidermal growth factor receptor . Positive_regulation EPHB2 HADHB 12534349 1079139 Moreover , we showed that both isoforms activate ERK phosphorylation in an Src-kinase dependent manner , whereas PKC was mainly implicated in [ERK] *activation* and EGFR phosphorylation by . Positive_regulation EPHB2 HAVCR2 22323453 2576109 This effect is highly specific as Tim-3 Ab blockade significantly decreased IFN-? production , and cross linking *induced* [ERK] activation and degradation of I?Ba . Positive_regulation EPHB2 HBEGF 11882602 919639 PD98059 inhibited *induced* [ERK] activation , whereas it had no effect on Akt activation by HB-EGF . Positive_regulation EPHB2 HBEGF 12070119 955784 Adiponectin also reduced PDGF-AA stimulated or *stimulated* [ERK] phosphorylation in a dose dependent manner without affecting autophosphorylation of PDGF alpha-receptor or EGF receptor . Positive_regulation EPHB2 HBEGF 15952178 1440637 The phosphatidylinositol 3'-kinase (PI3K) inhibitors LY294002 and wortmannin , and the MAPK/extracellular signal regulated kinase ( ERK ) kinase ( MEK ) inhibitors U0126 and PD98059 , reduced HB-EGF induced BrdU incorporation into cultures , and *enhanced* phosphorylation of Akt and [ERK] , implying a role for PI3K/Akt and MEK/ERK signaling in HB-EGF stimulated cell proliferation . Positive_regulation EPHB2 HBEGF 16737974 1585292 Exogenously administered *stimulated* [ERK] phosphorylation . Positive_regulation EPHB2 HBEGF 18990151 2028918 *Activation* of [Erk/MAPK] by was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation EPHB2 HBEGF 24188029 2921092 Here , we show that *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , [Mapk/Erk] pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation EPHB2 HBEGF 24877628 2951215 Matrix metalloproteinase 9 inhibitor treatment attenuated human chorionic gonadotropin- but not *induced* [ERK] activation and luteinization in primary granulosa cells . Positive_regulation EPHB2 HCRTR1 17188243 1680054 Attenuation of the IP3 elevation did not affect the *mediated* [ERK] ( extracellular signal regulated kinase ) activation in CHO cells , which supports our previous finding of the major importance of receptor operated Ca2+ influx for this response . Positive_regulation EPHB2 HDAC1 22311972 2571412 Using pharmacological inhibitors , we demonstrate that enhanced co-stimulatory receptor phenotype of Nrf2 ( -/- ) iDC does not require [ERK] activity but is *dependent* on activity , indicating a potential interaction between Nrf2 function and HDAC . Positive_regulation EPHB2 HDAC2 22311972 2571413 Using pharmacological inhibitors , we demonstrate that enhanced co-stimulatory receptor phenotype of Nrf2 ( -/- ) iDC does not require [ERK] activity but is *dependent* on activity , indicating a potential interaction between Nrf2 function and HDAC . Positive_regulation EPHB2 HDAC3 20470885 2327315 Correlating with the effect of HDAC inhibitors , depletion of also *blocked* the activation of [ERK] and PI3K by TGF-ß . Positive_regulation EPHB2 HDAC6 23770849 2937841 inhibition *diminishes* sustained activation of [ERK] and slows down the growth of these cells . Positive_regulation EPHB2 HFE 20634490 2334909 We showed that the silencing of and transferrin receptor 2 *reduced* both [Erk] phosphorylation and furin expression , that the exogenous expression of the two enhanced the induction of phosphoErk1/2 and furin by holotransferrin , but that this did not occur when the pathogenic HFE mutant C282Y was expressed . Positive_regulation EPHB2 HGF 11071904 748668 Together , these data demonstrate that in a sequential manner *activates* [ERK] and MKP2 , which in turn dephosphorylates JNK . Positive_regulation EPHB2 HGF 11287413 819806 Conversely , *induced* a sustained ( at least 12 h ) activation of [ERK] in the cells . Positive_regulation EPHB2 HGF 11533045 868825 *induced* strong activation of [ERK] in HepG2 cells . Positive_regulation EPHB2 HGF 11533045 868827 Although the serum dependent proliferation of HepG2 cells was inhibited by the MEK inhibitor PD98059 in a dose dependent manner , 10 microM PD98059 reduced the *induced* strong activation of [ERK] to a weak activation ; Positive_regulation EPHB2 HGF 11784715 916706 In addition , *induced* association of paxillin and activated [ERK] , correlating with a gel retardation of paxillin that was prevented with the ERK inhibitor U0126 . Positive_regulation EPHB2 HGF 11804875 903397 Further , we investigated the molecular mechanisms underlying the effects of HGF and IFN-gamma in BEAS-2B cells and found that the MEK1 inhibitor PD98059 , but not the p38 M-associated protein kinase inhibitor SB203580 , abrogates *induced* [ERK] activation and proliferation in response to HGF and serum . Positive_regulation EPHB2 HGF 11896055 944421 *stimulated* [ERK] activation increases the Gab1/PI3K association , whereas EGF stimulated ERK activation results in a decrease in the tyrosine phosphorylation of Gab1 and a decreased association with the PI3K . Positive_regulation EPHB2 HGF 12087056 959380 rapidly *stimulated* phosphatidylinositol 3'-kinase , [ERK] , p38 mitogen activated protein kinase , and protein kinase C activities . Positive_regulation EPHB2 HGF 12402004 1009364 *induced* phosphorylation of FAK and [Erk] was observed in both detached and attached SCCHN cells . Positive_regulation EPHB2 HGF 12941962 1157913 Finally , the increased phosphorylation of Gab1 by Src selectively potentiated *induced* activation of [ERK] and AKT . Positive_regulation EPHB2 HGF 14598883 1161245 Pretreatment of PD98059 decreased *mediated* phosphorylation of [extracellular receptor kinase (ERK)] , uPA secretion and expression of matrix metalloproteinases ( MMP-2 and MMP-9 ) in a dose dependent manner . Positive_regulation EPHB2 HGF 14598883 1161247 In contrast , SB203580 pretreatment increased *stimulated* [ERK] phosphorylation , uPA secretion and expression of MMPs . Positive_regulation EPHB2 HGF 14598883 1161249 SB203580 also reversed the inhibition of mediated [ERK] *activation* and uPA secretion in the PD98059 pretreated cells . Positive_regulation EPHB2 HGF 14598883 1161250 These results suggest that [ERK] *activation* by might play important roles in the metastasis of pancreatic cancer and the p38 MAPK pathway also involved in the HGF mediated uPA secretion and metastasis by regulation of ERK pathway . Positive_regulation EPHB2 HGF 14636584 1171268 In the present study we demonstrate that stimulates the localization of ERK to sites of cell-matrix interactions and that this is *mediated* by the tyrosine phosphorylation dependent association of inactive [ERK] and the focal adhesion complex protein paxillin . Positive_regulation EPHB2 HGF 14973553 1212488 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of ERK/mitogen activated protein kinase (MAPK) signaling mediated by fibroblast growth factor ( FGF-2 ) and both [ERK/MAPK] and Akt signaling *mediated* by . Positive_regulation EPHB2 HGF 15187417 1256464 Furthermore , *induced* [extracellular regulated kinase (ERK)] phosphorylation was slightly higher in the GnT-III transfectants than in the mock transfectants . Positive_regulation EPHB2 HGF 15187417 1256465 These results show that overexpression of GnT-III in HepG2 cells enhances HGF induced cell scattering , which may result from , at least in part , enhancement of *induced* [ERK] phosphorylation . Positive_regulation EPHB2 HGF 15194438 1259773 In contrast , [MAPK/ERK] phosphorylation was higher in *response* to and lasted longer , relative to IGF-I . Positive_regulation EPHB2 HGF 15277494 1277210 Stimulation of HLE B3 with *activated* the MAPKs , [ERK] , and JNK/SAPK , but not p38 . Positive_regulation EPHB2 HGF 15293345 1278952 Adenovirus mediated gene transfer induced overexpression of HGF in some seminiferous epithelial cells and interstitial cells , *increased* the phosphorylation of [ERK] and Akt , and decreased numbers of apoptotic cells of germ cells . Positive_regulation EPHB2 HGF 15367691 1294843 Embryonic IMCD cells expressing predominantly Gpc3 proliferated and migrated in *response* to but activated [ERK] only transiently and failed to form tubules . Positive_regulation EPHB2 HGF 15367691 1294848 Overexpressing Gpc-4 but not Gpc-3 or Gpc-1 led to sustained *stimulated* [ERK] activation and rescued the tubulogenic response in these cells . Positive_regulation EPHB2 HGF 15509706 1328052 however , for human OSE cells , only mildly *stimulated* [ERK] phosphorylation and failed to stimulate OSE cell growth . Positive_regulation EPHB2 HGF 15713673 1395917 SSB-1 also enhanced *induced* [Erk] phosphorylation . Positive_regulation EPHB2 HGF 15922473 1427191 However , *increased* phosphorylated p90-RSK and [ERK] to 18- and 3-fold normal , respectively . Positive_regulation EPHB2 HGF 16189274 1507729 In MET positive DLBCL cells , *induces* MEK dependent activation of [ERK] and PI3K dependent phosphorylation of PKB , GSK3 , and FOXO3a . Positive_regulation EPHB2 HGF 16449979 1534237 treatment in both cell lines *induced* rapid , sustained activation of Met , [ERK] and AKT . Positive_regulation EPHB2 HGF 16449979 1534242 ( - ) -Epigallocatechin ( EGC ) , however , completely repressed *induced* AKT and [ERK] phosphorylation at concentrations of 10 and 20 microM , but was incapable of blocking Met activation . Positive_regulation EPHB2 HGF 16724983 1565614 In contrast , did not *induce* phosphorylation of [ERK] and JNK . Positive_regulation EPHB2 HGF 16912161 1601778 We also showed Rap1 and [ERK] *activation* by both and 8CPT-2Me-cAMP ( an activator of Epac , a Rap1 guanine nucleotide exchange factor ) in two human melanoma cell lines . Positive_regulation EPHB2 HGF 16912161 1601779 In addition , the *activation* of [ERK] by was reduced , at least in part , by small interfering RNAs against Rap1 and a dominant negative Rap1 . Positive_regulation EPHB2 HGF 17154373 1678837 Consistently , HGF inhibits growth under HD but stimulates growth under LD . *induced* sustained high [ERK] activation under HD as compared to LD . Positive_regulation EPHB2 HGF 17154373 1678839 This involves cell density dependent differences in *induced* [ERK] activation . Positive_regulation EPHB2 HGF 17349975 1712386 at S phase *induces* G2 delay through sustained [ERK] activation . Positive_regulation EPHB2 HGF 17349975 1712387 Taken together , treatment of HeLa cells at S phase *induces* G2 delay partially through sustained activation of [ERK] signaling . Positive_regulation EPHB2 HGF 17658483 1776369 However ISCK03 did not inhibit *induced* phosphorylation of p44/42 [ERK] proteins . Positive_regulation EPHB2 HGF 17961621 1844759 The effect of apigenin on HGF induced signaling activation involving invasive growth was evaluated by immunoblotting analysis , it shows that apigenin blocks the *induced* Akt phosphorylation but not Met , [ERK] , and JNK phosphorylation . Positive_regulation EPHB2 HGF 18003605 1851487 Knockdown of Gab1 using siRNA suppressed the *induced* strong activation of [ERK] and inhibition of HepG2 cell proliferation . Positive_regulation EPHB2 HGF 18083897 1862229 Among the mediators downstream of c-Met , the activation of extracellular signal regulated kinase ( [ERK] ) was reduced by doxorubicin , but the activity was *restored* by . Positive_regulation EPHB2 HGF 18083897 1862230 These beneficial effects appear to be related to *induced* [ERK] activation and upregulation of c-Met , GATA-4 , and sarcomeric proteins . Positive_regulation EPHB2 HGF 18491380 1927923 These results suggest that maleic acid indirectly *induced* expression from human dermal fibroblasts through activation of [ERK] and JNK and that de novo protein synthesis is required for maleic acid induced upregulation of HGF mRNA . Positive_regulation EPHB2 HGF 18782770 1986054 In contrast , can *stimulate* [ERK] phosphorylation independent of the EGFR . Positive_regulation EPHB2 HGF 18822689 1970531 treatment *induced* the phosphorylation of [ERK] and p38 kinase in a dose dependent manner , resulting in an early peak of phosphorylation at 3 to 10 min , which then rapidly decreased to a near basal level . Positive_regulation EPHB2 HGF 19427096 2101216 Decreased expression of c-Met , the receptor for hepatocyte growth factor , was also detected in the Hn1 depleted cells , however *dependent* stimulation of [phosphorylated-ERK] was unaffected . Positive_regulation EPHB2 HGF 19567783 2111201 Inhibition of the *induced* high-intensity [ERK] activity had a modest effect on the Id1 down-regulation , and inhibition of the phosphatidylinositol 3-kinase pathway had no effect , showing that Id1 is regulated by ERK dependent and -independent pathways other than the phosphatidylinositol 3-kinase pathway . Positive_regulation EPHB2 HGF 19778541 2159191 [ERK] also was *activated* by and rescued cells from apoptosis , although the cytoprotective effect was less marked than for PI3K/Akt . Positive_regulation EPHB2 HGF 20623641 2291731 EGCG added up to 4 h after the addition of HGF still blocked cell scattering and reduced the *induced* phosphorylation of c-Met , Akt , and [Erk] , suggesting that EGCG could act both by preventing activation of c-Met by HGF and by attenuating the activity of pathways already induced by HGF . Positive_regulation EPHB2 HGF 20661223 2322306 Sprouty-2 transfectants showed strong upregulation of c-Met protein and mRNA transcripts and *stimulated* [ERK] and Akt phosphorylation and enhanced cell migration and invasion . Positive_regulation EPHB2 HGF 20728428 2318105 [Erk] *activation* by is found to mediate the interaction of Par6 with GTP loaded Cdc42 . Positive_regulation EPHB2 HGF 21586278 2445640 Although there is published evidence indicating a role for 2-O sulfation in HGF binding , primary epithelial cells isolated from Hs2st conditional deletions were able to activate [Erk] in the *presence* of and there appeared to be only a slight reduction in HGF mediated c-Met phosphorylation in these cells compared to control . Positive_regulation EPHB2 HGF 22261330 2564489 Furthermore , Immunoblotting studies revealed that *induced* phosphorylation of [ERK] , and pre-treatment with U0126 , a MAPK/ERK inhibitor , partially inhibited hHGF induced increase in AQP3 expression . Positive_regulation EPHB2 HGF 24326130 2880320 Amuvatinib at concentrations of 5 , 10 , or 25 µM readily inhibited *dependent* MET , AKT , [ERK] and GSK-3-beta phosphorylation . Positive_regulation EPHB2 HGF 24378092 2883464 In the *presence* of , the expression of p-Met , p-Akt and [p-ERK] proteins in the H1975 cells was markedly up-regulated . Positive_regulation EPHB2 HIF1A 14681237 1211319 In support of the observation that superoxide mediated the SW-induced [ERK] activation and *transactivation* , we further demonstrated that scavenging of superoxide by superoxide dismutase and inhibition of ERK activity by PD98059 decreased HIF-1alpha activation and VEGF-A levels . Positive_regulation EPHB2 HMGB1 17697615 1782265 *induced* the phosphorylation of p38 , JNK and [ERK] in k562 cells . Positive_regulation EPHB2 HMGB1 21944254 2487912 Luciferase assays document that over-expression of *increases* the transcriptional activity of JNK and [ERK] , which may be silenced by siRNA . Positive_regulation EPHB2 HMGB1 21944254 2487913 The results suggest that *regulates* JNK and [ERK] required for autophagy , which provides a potential drug target for therapeutic interventions in childhood CML . Positive_regulation EPHB2 HMGB1 23261684 2732449 Our findings provide evidence that in the diabetic retina , possibly interacts with RAGE and *activates* [ERK] ( 1/2 ) and NF-?B to generate an inflammatory response and disrupt retinal vascular barrier . Positive_regulation EPHB2 HMGB1 24091596 2874534 stimulation of HSC *increased* the phosphorylation of Src and [Erk] and HMGB1 induced HSC migration was blocked by the Src inhibitor PP2 and the Erk inhibitor U0126 . Positive_regulation EPHB2 HMOX1 15993334 1429654 Whereas inhibiting the ERK pathway with the MEK inhibitor PD98059 significantly decreased HNE mediated [ERK] phosphorylation , c-Fos protein induction , AP-1 binding , and protein *induction* , inhibition of the ERK pathway had no effect on HNE induced HO-1 mRNA . Positive_regulation EPHB2 HMOX1 16781459 1573425 Both H ( 2 ) S solution prepared by bubbling pure H ( 2 ) S gas and NaSH , a H(2)S donor , dose dependently *induced* expression through the activation of the extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 HMOX1 21645546 2459399 Furthermore , Schisandrin *induced* expression of RAW 264.7 cells through Nrf-2 , PI3K/Akt , and [ERK] activation . Positive_regulation EPHB2 HMOX1 23073806 2690046 Moreover , ß-PGG *induced* Nrf2 nuclear translocation , which was found to be upstream of ß-PGG induced HO-1 expression , and the activation of [ERK] and Akt , a pathway that is involved in ß-PGG induced Nrf2 nuclear translocation , expression and neuroprotection . Positive_regulation EPHB2 HNRNPD 19304659 2073388 Mechanism of sustained *activation* of ribosomal S6 kinase ( RSK ) and [ERK] by kaposi sarcoma associated herpesvirus ORF45 : complexes retain active phosphorylated ERK AND RSK and protect them from dephosphorylation . Positive_regulation EPHB2 HNRNPD 19319189 2052417 GTP-Raf-MEK-ERK to *promote* sustained [ERK] activation and regulate H-Ras dependent neuritogenesis . Positive_regulation EPHB2 HNRNPF 20967853 2369594 Selective [ERK] activation *induced* mouse and human to secrete bioactive transforming growth factor ß , a process required for suppression of T cell responses and differentiation of antigen-specific Treg cells . Positive_regulation EPHB2 HNRNPH1 20967853 2369595 Selective [ERK] activation *induced* mouse and human to secrete bioactive transforming growth factor ß , a process required for suppression of T cell responses and differentiation of antigen-specific Treg cells . Positive_regulation EPHB2 HOMER1 18184796 1856663 Disruption of interactions selectively *blocks* mGluR activation of the phosphoinositide 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) , but not [ERK] ( extracellular signal regulated kinase ) , pathway and translation of a 5 ' terminal oligopyrimidine tract containing mRNA , Elongation factor 1alpha . Positive_regulation EPHB2 HOMER2 18184796 1856664 Disruption of interactions selectively *blocks* mGluR activation of the phosphoinositide 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) , but not [ERK] ( extracellular signal regulated kinase ) , pathway and translation of a 5 ' terminal oligopyrimidine tract containing mRNA , Elongation factor 1alpha . Positive_regulation EPHB2 HOMER3 18184796 1856665 Disruption of interactions selectively *blocks* mGluR activation of the phosphoinositide 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) , but not [ERK] ( extracellular signal regulated kinase ) , pathway and translation of a 5 ' terminal oligopyrimidine tract containing mRNA , Elongation factor 1alpha . Positive_regulation EPHB2 HOXD13 11323408 834256 The [ERK] *activation* by is pertussis toxin-sensitive in contrast to ERK activation by bombesin , which is pertussis toxin-insensitive but dependent on epidermal growth factor receptor phosphorylation . Positive_regulation EPHB2 HPSE 23048032 2702753 In the present study , myeloma cell lines expressing either high or low levels of heparanase were utilized to determine how *stimulates* [ERK] signaling . Positive_regulation EPHB2 HPSE 23048032 2702754 Blocking insulin receptor function with antibody or a small molecule inhibitor or knockdown of IRS-1 expression using shRNA diminished mediated [ERK] *activation* in the tumor cells . Positive_regulation EPHB2 HPSE 23048032 2702755 In addition , up-regulation of the insulin signaling pathway by and the resulting [ERK] *activation* were dependent on heparanase retaining its enzyme activity . Positive_regulation EPHB2 HRAS 10092503 600517 Recently , radicicol was reported as an inhibitor of *induced* [ERK] activation . Positive_regulation EPHB2 HRAS 10340949 616232 ( 2 ) active is *sufficient* for [ERK] activation but is insufficient for maximal activation of JNK or p38 ; Positive_regulation EPHB2 HRAS 10402467 628936 and MAP kinase kinase (MEK) were *necessary* and sufficient for uPA induced [ERK] activation and stimulation of cellular migration , as demonstrated in experiments with dominant negative and constitutively active mutants of these signaling proteins . Positive_regulation EPHB2 HRAS 10571061 568489 function was *required* for [ERK] activation by phorbol esters in cardiac myocytes , but not in cardiac fibroblasts . Positive_regulation EPHB2 HRAS 10636931 660196 These data indicate that rPMT employs G ( q/11 ) family heterotrimeric G proteins to induce *dependent* [Erk] activation via protein kinase C-independent `` transactivation '' of the epidermal growth factor receptor . Positive_regulation EPHB2 HRAS 10667210 578486 Treatment of fibroblast cells with this compound had very little effect on *mediated* activation of [ERK] and JUN kinase activities . Positive_regulation EPHB2 HRAS 10749883 698487 These data clearly demonstrate that the alpha-thrombin induced activation coordinately *regulates* [ERK] and PI 3-kinase activities , both of which are required for expression of cyclin D1 protein and progression through G ( 1 ) . Positive_regulation EPHB2 HRAS 10898494 712062 Here , we analyzed the effects of Vav on three known downstream targets of , i. e. *activation* of [ERK] and NFAT , and up-regulation of the activation antigen CD69 . Positive_regulation EPHB2 HRAS 10898494 712076 Conversely , however , dominant negative Vav did not inhibit NFAT and [ERK] activation or CD69 expression *induced* by an active mutant . Positive_regulation EPHB2 HRAS 10962574 727226 These results suggest that Smad4 acts inhibiting *dependent* [Erk] signalling activity in Ras transformed keratinocytes . Positive_regulation EPHB2 HRAS 10976990 729633 In contrast to their implication in epidermal growth factor (EGF) receptor tyrosine kinase signaling , the adaptor protein Shc , the Grb2/Sos complex , and the small G protein were not *involved* in the activation of [Erk] induced by either LPA or PGF2alpha in MC3T3-E1 cells , suggesting that activation of Erk by Gi and Gq protein coupled receptors is Ras independent in these cells . Positive_regulation EPHB2 HRAS 11005808 752484 Surprisingly , a role for in the heat shock response was eliminated by the failure of a dominant negative Ras ( Asn-17 ) mutant to *inhibit* [ERK] MAPK activation and the failure to observe increases in Ras . Positive_regulation EPHB2 HRAS 11018025 752777 Expression of a dominant negative mutant of Ras also did not significantly impair calcium induced ERK activation , indicating that calcium mediated [ERK] activation does not *require* active . Positive_regulation EPHB2 HRAS 11027277 738756 PI3-K and endocytosis may also regulate ERK signaling at a second site downstream of Ras , since both rapid [ERK] activation and the dependent *activation* of the MAP kinase kinase kinase B-Raf are blocked by inhibition of either PI3-K or endocytosis . Positive_regulation EPHB2 HRAS 11075808 749025 As reported elsewhere , acute expression of ( v12 ) also *induces* mitotic defects in PCCL3 cells through [ERK] ( extracellular ligand regulated kinase ) activation , suggesting that apoptosis may be secondary to DNA damage . Positive_regulation EPHB2 HRAS 11088001 764958 We show that the activation of [ERK] via SSTR1 is mediated by the betagamma subunit of a pertussis toxin-sensitive G-protein and *requires* both the small G protein and the serine/threonine kinase Raf-1 . Positive_regulation EPHB2 HRAS 11262176 796249 However , *induced* activation of the mitogen activated protein kinase [ERK] has been suggested to play a critical role in either growth or differentiation in different model systems . Positive_regulation EPHB2 HRAS 11269657 797343 Arsenite inhibits *dependent* activation of [ERK] but activates ERK in the presence of oncogenic Ras in baboon vascular smooth muscle cells . Positive_regulation EPHB2 HRAS 11418608 843262 VPA induced *activation* of [ERK] was blocked by the mitogen activated protein kinase/ERK kinase inhibitor PD098059 and dominant negative and Raf mutants but not by dominant negative stress activated protein kinase/ERK kinase and mitogen activated protein kinase kinase 6 mutants . Positive_regulation EPHB2 HRAS 11574537 882423 NT-stimulated [Erk] activity *requires* activation because overexpression of the dominant negative Ras mutant Ras-17N almost completely inhibits the Erk activation . Positive_regulation EPHB2 HRAS 11681720 873910 Overexpression of dominant negative mutant *suppressed* GH-stimulated [ERK] activation . Positive_regulation EPHB2 HRAS 11682481 888558 In contrast , activation of [ERK] was largely *dependent* on . Positive_regulation EPHB2 HRAS 11791173 901782 Here we determined the efficacy of Shc and N-Shc toward Erk activation in NGF treated PC12 cells , and found that N-Shc transduced dependent [Erk] *activation* less efficiently than Shc . Positive_regulation EPHB2 HRAS 11799108 922214 In contrast , Ras induced focus formation , platelet derived growth factor ( PDGF ) - , or Ras induced phospho-Akt levels and cell adhesion to fibronectin were affected by T35S and Y40C EDMs , whereas PDGF- or *induced* [phospho-Erk] levels were affected only by the T35S EDM , implying that a more limited set of Ras mediated pathways participate in these phenotypes . Positive_regulation EPHB2 HRAS 11821947 908914 To investigate the specific role of A-Raf in this process we generated A-Raf deficient mouse embryonic fibroblasts ( MEFs ) and embryonic stem ( ES ) cells by gene targeting and characterized their ability to undergo proliferation , differentiation , apoptosis , [ERK] *activation* , and transformation by oncogenic and Src . Positive_regulation EPHB2 HRAS 12014647 941636 To examine the *role* of the transforming in controlling [ERK] signaling , transfection of an activated Ha-ras allele was tested in a squamous cell carcinoma cell line . Positive_regulation EPHB2 HRAS 12082537 958580 In exponentially growing cells , oncogenic *had* no effect on proliferation rates , [Erk] phosphorylation , or the level of cyclin D1 , and Ras-induction did not confer serum independent growth . Positive_regulation EPHB2 HRAS 12193071 981001 Thus , p38 MAP kinase stimulation could perhaps partially account for ET-1 contractive properties , whereas ET-1 induced cell proliferation occurs primarily via *dependent* activation of the [ERK] . Positive_regulation EPHB2 HRAS 12193740 981552 We conclude that *mediated* activation of [ERK] is critical for beta ( 2 ) -integrin adhesion and that Ras-protein functions as the common regulator for cytokine- , chemokine- , and G-protein coupled receptors in human eosinophils . Positive_regulation EPHB2 HRAS 12364324 1019131 GLP1 stimulated activation of [Erk] is blocked by inhibitors of MEK , but GLP1 does not *induce* the activation of A-Raf , B-Raf , C-Raf , or . Positive_regulation EPHB2 HRAS 12379659 1034799 Moreover , Erbin inhibits the [Erk] *activation* by active , while it fails to do so in the presence of active Raf-1 . Positive_regulation EPHB2 HRAS 12439598 1016859 mediated *activation* of [ERK] by cisplatin induces cell death independently of p53 in osteosarcoma and neuroblastoma cell lines . Positive_regulation EPHB2 HRAS 12439598 1016863 Our results suggest that cisplatin induced activation of [ERK] is *mediated* by . Positive_regulation EPHB2 HRAS 12446729 1037527 *dependent* [ERK] activation by the human G ( s ) -coupled serotonin receptors 5-HT4 ( b ) and 5-HT7 ( a ) . Positive_regulation EPHB2 HRAS 12473665 1055928 *mediated* peak stimulation of [ERK] by PACAP , whereas Rap1 was necessary for the sustained activation phase . Positive_regulation EPHB2 HRAS 12600818 1085057 was *required* for maximal activation of extracellular signal regulated kinase ( [ERK] ) and Jun amino terminal kinase (JNK) as well as AP-1 and NF-kappaB transcriptional activities , but not for activation of IkappaB kinase (IKK)-beta , an upstream activator of NF-kappaB . Positive_regulation EPHB2 HRAS 12706116 1082480 In PC12 cells , NGF and EGF induce a rapid translocation of [GFP-Erk] that *requires* and Mek . Positive_regulation EPHB2 HRAS 12855697 1134964 This unresponsiveness is associated with the constitutive activation of the small G protein , Rap1 , and the lack of *dependent* activation of [ERK] . Positive_regulation EPHB2 HRAS 12902401 1121105 LPA induced chemotaxis is markedly dependent on activation of PTX-sensitive heterotrimeric G-proteins , on *activation* of the small GTPases , Rac and RhoA , and on GTPase dependent activation of [ERK] . Positive_regulation EPHB2 HRAS 12966092 1164377 EGFR phosphorylation , in turn , led to *dependent* [Erk] activation . Positive_regulation EPHB2 HRAS 12975377 1164601 This inhibition is specific to Cot , because *induced* [ERK] and IkappaB kinase induced NF-kappaB activation are not significantly affected by hKSR-2 co-expression . Positive_regulation EPHB2 HRAS 14607972 1162187 Functionally , Rap1 either interferes with mediated [ERK] *activation* or activates ERK independently of Ras in a cell-context dependent manner . Positive_regulation EPHB2 HRAS 15029245 1228104 Developmentally regulated *role* for in coupling NMDA glutamate receptors to Ras , [Erk] and CREB . Positive_regulation EPHB2 HRAS 15062121 1230750 Signal transduction : implications for *dependent* [ERK] signaling . Positive_regulation EPHB2 HRAS 15516985 1343129 was also constitutively active in patient NK cells , and exposure of cells to the Ras inhibitor FTI2153 or to dominant-negative-Ras *resulted* not only in [ERK] inhibition but also in enhanced apoptosis in both the presence and absence of anti-Fas . Positive_regulation EPHB2 HRAS 15630138 1362336 The Sprouty related Ena/VASP homology 1-domain containing protein ( Spred)-1 has recently been identified as a negative regulator of growth factor mediated , *dependent* [ERK] activation . Positive_regulation EPHB2 HRAS 15677464 1388359 In contrast , [Raf-MEK-ERK] and phosphatidylinositol 3-kinase-Akt pathways , which are fundamental to proliferation and differentiation , are *activated* by both and N-Ras . Positive_regulation EPHB2 HRAS 16041367 1437716 Prohibitin is required for induced [Raf-MEK-ERK] *activation* and epithelial cell migration . Positive_regulation EPHB2 HRAS 16088958 1460660 Inhibition of significantly *blocked* the activation of Raf-1 , [ERK] , and c-Jun and the stimulation of COX-2 expression in response to serum . Positive_regulation EPHB2 HRAS 16214133 1468839 In addition , transfection of ES cells with DN-Src , or DN-Ras partially inhibited 8-Br-cAMP induced ERK1/2 and consequently PLD activation , whereas cotransfection of DN-Src and DN-Ras completely inhibited ERK1/2 and PLD activation , suggesting that Src and independently *regulate* [ERK/PLD] activation . Positive_regulation EPHB2 HRAS 16214133 1468895 Taken together , these results demonstrate a novel pathway in ES cells that 8-Br-cAMP activate PLD through PKA and ERK1/2 and this [ERK/PLD] activation by 8-Br-cAMP is *mediated* by Src and , separately . Positive_regulation EPHB2 HRAS 16267393 1479011 A substitution that mimics constitutive phosphorylation ( S518D ) abrogated the ability of merlin to suppress effects of the Ras-ERK signaling pathway such as Ras induced SRE transactivation , Elk mediated SRE transactivation , *induced* [ERK] phosphorylation and Ras induced focus formation . Positive_regulation EPHB2 HRAS 16301319 1511017 It inhibits mediated *activation* of [ERK] in response to growth factors . Positive_regulation EPHB2 HRAS 16339563 1491665 In that pharmacological inhibitors of PI3K inhibited LPS induced activation of , but not *activation* of [ERK] , we concluded that LPS induced activation of ERK occurs through a pathway that is not dependent on the activation of p21Ras . Positive_regulation EPHB2 HRAS 16436505 1540511 In addition , we demonstrated that Tat activation of , but not of Rac , *induces* [ERK] phosphorylation . Positive_regulation EPHB2 HRAS 16478791 1528368 APC inhibits [ERK] pathway activation and cellular proliferation *induced* by . Positive_regulation EPHB2 HRAS 16478791 1528389 The GTP loading and the protein level of mutated RAS were decreased in cells with reduced ERK activity as a result of APC overexpression , indicating that APC regulates induced [ERK] *activation* at least partly by reduction of the RAS protein level . Positive_regulation EPHB2 HRAS 16709153 1598862 However , a biochemical link between PE and GAP inactivation is missing and GEF stimulation is hard to reconcile with the observation that dominant negative S17N-Ras does not compromise *dependent* [ERK] ( extracellular-signal regulated kinase ) activation by PE . Positive_regulation EPHB2 HRAS 16860436 1632241 Inhibitors of epidermal growth factor receptor (EGFR) ( AG 1478 ) , and Raf , as well as antioxidants *inhibited* activation of [ERK] and Akt , while the Src inhibitor PP2 had no effect . Positive_regulation EPHB2 HRAS 16959871 1646778 Overexpression of G ( alpha- ) transducin , showed that G ( betagamma ) -subunit activation is only partially required for ERK1/2 phosphorylation and does not play a role in p38 MAPK phosphorylation , whereas overexpression of a dominant negative ( Ras N17 ) *attenuated* both [ERK] and p38 MAPK activation . Positive_regulation EPHB2 HRAS 17045653 1666543 In the present study , we investigated the *role* of in FLG- and LPS mediated signaling in [ERK] activation in chicken heterophils . Positive_regulation EPHB2 HRAS 17174095 1688100 Kinase Suppressor of Ras (KSR) is a molecular scaffold that interacts with the core kinase components of the ERK cascade , Raf , MEK , and ERK and provides spatial and temporal regulation of *dependent* [ERK] cascade signaling . Positive_regulation EPHB2 HRAS 17374607 1734753 Axin inhibits cellular proliferation and [ERK] pathway activation *induced* by either epidermal growth factor or , indicating a role of Axin in the regulation of growth induced by ERK pathway activation . Positive_regulation EPHB2 HRAS 17440079 1729376 Moreover , although the initial activation of Ras and PAK2 are distinctly regulated , TGF-beta stimulated PAK2 activity is required for *dependent* [ERK] phosphorylation and Elk-1 transcription . Positive_regulation EPHB2 HRAS 17450518 1761002 HUVEC stably transfected with dominant negative Ras abrogated XIAP preservation by cPGI ( 2 ) while constitutive active *increased* [ERK] phosphorylation and protected XIAP from degradation . Positive_regulation EPHB2 HRAS 17562163 1798033 Inhibitors of growth factor receptor ( AG1478 ) and Src ( PP2 ) and the antioxidant N-acetylcysteine did not affect activation of ERK and Akt , while the and Raf inhibitors *inhibited* activation of [ERK] , but not Akt . Positive_regulation EPHB2 HRAS 18275061 1924757 As further support for Ras mediated signaling , constitutively active ( ca ) *promoted* [MEK/ERK] activation and osteoclast survival , which was blocked by inhibition of PI3K or Raf . Positive_regulation EPHB2 HRAS 18604197 1941626 Thus , IQGAP3 regulates the promotion of cell proliferation through dependent [ERK] *activation* . Positive_regulation EPHB2 HRAS 19218240 2054345 BLNK binds active to *promote* B cell receptor mediated capping and [ERK] activation . Positive_regulation EPHB2 HRAS 20179705 2222196 Induction of [ERK] signalling requires direct binding of the drug to the ATP binding site of one kinase of the dimer and is *dependent* on activity . Positive_regulation EPHB2 HRAS 20452986 2282977 In this study we tested if activation of [ERK] and cPLA(2) occurred as a *result* of signaling during infection and determined the relative contribution of these signaling components to chlamydial replication and survival . Positive_regulation EPHB2 HRAS 21330403 2420297 Measurements of the dephosphorylation of [ERK] and the *activation* of showed that the ROS scavenger prevents the cAMP provoked activation of Ras and that cAMP , with or without a ROS scavenger , has little or no effect on the dephosphorylation of ERK . Positive_regulation EPHB2 HRAS 21678474 2483649 Furthermore , we demonstrate the mechanism for PLD1 activation of [ERK] *involves* . Positive_regulation EPHB2 HRAS 21949793 2488009 Like costimulation via CD28 , active *induced* AKT , JNK and [ERK] phosphorylation . Positive_regulation EPHB2 HRAS 22592532 2614450 To do so , we determined the role of CaMKII in Raf-1 and [ERK] *activation* by oncogenic and other factors . Positive_regulation EPHB2 HRAS 22592532 2614454 Serum , fibronectin , Src ( Y527 ) and ( V12 ) *activated* CaMKII and [ERK] , at different extents . Positive_regulation EPHB2 HRAS 22617030 2614666 Autonomous [ERK] activation by uPAR *requires* and Rac1 . Positive_regulation EPHB2 HRAS 22975374 2673976 Without EGFR activity , active levels are not *sufficient* to induce robust [MEK/ERK] activity , a requirement for epithelial transformation . Positive_regulation EPHB2 HRAS 23893412 2839578 The first step of *dependent* activation of [ERK] signaling is Ras binding to members of the Raf family of MAP kinase kinase kinases , C-Raf and B-Raf . Positive_regulation EPHB2 HRAS 23893412 2839595 Both B-Raf and C-Raf were constitutively bound to oncogenic Ras and contributed to *dependent* [ERK] activation . Positive_regulation EPHB2 HRAS 23893412 2839601 cAMP inhibited the growth of H1299 cells and *dependent* [ERK] activation via PKA . Positive_regulation EPHB2 HRAS 24309939 2877892 Molecular docking analysis suggested that WA could bind to HRas-GTP , causing accumulation of and excessive *activation* of [Raf/ERK/p53-p21] . Positive_regulation EPHB2 HRAS 24327733 2880369 Unexpectedly , we found that in PIK3CA mutant and HER2 amplified breast cancers sensitive to PI3K inhibitors , PI3K inhibition led to a rapid suppression of Rac1/p21 activated kinase (PAK)/protein kinase C-RAF ( C-RAF ) / protein kinase MEK ( MEK ) [/ERK] signaling that did not *involve* . Positive_regulation EPHB2 HRAS 24711380 2935544 It is known that Erbin inhibits *mediated* activation of the extracellular signal regulated kinase ( [ERK] ) by binding to Soc-2 suppressor of clear homolog ( Shoc2 ) . Positive_regulation EPHB2 HRAS 25002533 2952821 These data show that caveolin-1 is necessary for optimal KSR1 dependent [ERK] *activation* by growth factors and oncogenic . Positive_regulation EPHB2 HRAS 9309148 454737 Treatment of fibroblast cells with this compound had very little effect on mediated *activation* of [ERK] and Jun kinase activities . Positive_regulation EPHB2 HRAS 9351826 466072 However , the resulting secondary activation of at 30 min does not *lead* to [ERK] activation , correlating with intensive , ET-1 induced expression of MAP kinase phosphatase-1 , but does result in increased p21ras associated phosphatidylinositol 3-kinase activity . Positive_regulation EPHB2 HRAS 9399643 469204 Treatment of fibroblast cells with this compound had very little effect on mediated *activation* of [ERK] and JUN kinase activities . Positive_regulation EPHB2 HRAS 9407076 470809 We have shown previously that *stimulated* [ERK] activation is essential for the induction and continued G1 expression of cyclin D1 . Positive_regulation EPHB2 HRAS 9632795 513077 These observations suggest that Gab1 acts as an adapter molecule in transmitting signals to ERK MAP kinase for the cytokine receptor gp130 and that SHP-2 , PI-3 kinase , and are *involved* in Gab1 mediated [ERK] activation . Positive_regulation EPHB2 HRAS 9774335 539658 Surprisingly , activation of endogenous Rap1 fails to affect *dependent* [ERK] activation . Positive_regulation EPHB2 HRAS 9892010 586556 We show that the activation of [ERK] via SSTR1 is pertussis toxin sensitive and *requires* the small G protein , phosphatidylinositol 3-kinase , the serine/threonine kinase Raf-1 , and the protein tyrosine phosphatase SHP-2 . Positive_regulation EPHB2 HRG 16428439 1515974 Furthermore , inactivation of Rac by expression of the Rac GTPase activating protein beta2-chimerin inhibited *induced* [ERK] activation , mitogenicity , and migration in breast cancer cells . Positive_regulation EPHB2 HRG 17619951 1798246 Akt and [ERK] were *activated* by under SD and hypoxia conditions , but HRG had no effects on the activation of JNK and p38 . Positive_regulation EPHB2 HRG 18004277 1827226 Model analysis and experimental validation show that ( i ) ErbB2 overexpression , which occurs in approximately 25 % of all breast cancers , transforms transient EGF induced signaling into sustained signaling , ( ii ) *induced* [ERK] activity is much more robust to the ERK cascade inhibitor U0126 than EGF induced ERK activity , and ( iii ) phosphoinositol-3 kinase is a major regulator of post-peak but not pre-peak EGF induced ERK activity . Positive_regulation EPHB2 HSP90AA1 15999212 1430643 We showed that inhibitors *reduce* [ERK] phosphorylation without affecting the total ERK protein level . Positive_regulation EPHB2 HSP90AA1 18281615 1911672 Analysis of the expression of and *activation* of the [MEK/ERK] downstream signaling of B-Raf was performed by Western blot . Positive_regulation EPHB2 HSP90AA1 18281615 1911688 The inhibition of downregulated B-Raf , decreased cell proliferation , and *reduced* activation of [MEK/ERK] in uveal melanoma cell lines expressing WT B-Raf . Positive_regulation EPHB2 HSP90AA1 20015528 2241180 Inhibition of effectively *diminished* the constitutive phosphorylation of Akt , [Erk] , and STAT3 in PHHs . Positive_regulation EPHB2 HSPB1 20149037 2179047 The interaction between Hsp27 and MAPK was increased , suggesting that phosphorylation of might be *induced* by p38 and [ERK] in placentas from patients with pre-eclampsia . Positive_regulation EPHB2 HSPB1 24275576 2921358 Caldesmon- and *mediated* change in myosin adenosine triphosphatase activity and [Erk] and p38MAPK played an important role in this process . Positive_regulation EPHB2 HSPD1 19306954 2080129 In addition , *activated* p38 and NFkappaB , but not [ERK] or JNK ; Positive_regulation EPHB2 HSPD1 21854881 2496061 gene transfer *activated* [ERK] and Akt and reduced Bax and cytochrome c release , as well as caspase-3 cleavage , which attenuated the inhibitory effects of glucocorticoid treatment on osteoblast survival . Positive_regulation EPHB2 HSPG2 10341225 616265 However , neither inhibition of nor chelation of calcium significantly *reduced* ATP stimulated [ERK] activity . Positive_regulation EPHB2 HSPG2 12039977 949572 Thus , proximal tubular OK cells express a CaR that mediates Ca ( 2+ ) ( i ) mobilization and PIP ( 2 ) <-PLC> *dependent* [ERK] activation in response to AGAs and thus could play a role in AGA induced nephrotoxicity . Positive_regulation EPHB2 HSPG2 12055094 951670 Inhibition of by U-73122 or of phosphoinositide (PI) 3-kinase by wortmannin partially *reduced* [ERK] activation . Positive_regulation EPHB2 HSPG2 14648542 1188333 LPA- and S1P induced [ERK] phosphorylation was *dependent* on the activation of mitogen activated protein kinase (MAPK) , , and protein kinase C ( PKC ) , but was insensitive to pertussis toxin (PTX) . Positive_regulation EPHB2 HSPG2 14676843 1202515 Inhibition of *resulted* in complete inhibition of [ERK] , while having no affect on p38 activity . Positive_regulation EPHB2 HSPG2 14680820 1179173 However , TCR induced [ERK] activation was *suppressed* by inhibitors of PKC and . Positive_regulation EPHB2 HSPG2 15177934 1255163 The effects of NT on [EGFR/ERK/Akt] activation and DNA synthesis were *attenuated* by ( U73122 ) , PKC-inhibitors ( bisindolylmaleimide , staurosporine , rottlerin ) , MEK inhibitor ( U0126 ) and PI3 kinase inhibitors ( wortmannin , LY 294002 ) . Positive_regulation EPHB2 HSPG2 15471881 1342461 The presence of the inhibitor U73122 or the calcium chelator 1,2-bis ( 2-aminophenoxy ) ethane-N , N, N ' , N'-tetraacetic acid tetrakis ( acetoxymethyl ester ) ( BAPTA-AM ) *blocked* both [ERK] and Ras activation , suggesting that both PLC and calcium are required for ERK activation . Positive_regulation EPHB2 HSPG2 15750341 1379867 These findings indicate that [ERK] phosphorylation in response to glycated LDL *involves* the activation of PKC , , and MEK , but is independent of intracellular Ca2+ . Positive_regulation EPHB2 HSPG2 15917990 1413205 PAF induced [ERK] phosphorylation is *mediated* by PI3K , PKC , PLA2 , , and extracellular calcium , whereas fMLP induced ERK phosphorylation does not involve the PKC-gamma isoform and extracellular calcium . Positive_regulation EPHB2 HSPG2 18367332 1892596 These results demonstrate that PSs regulate Erk activity through a PKCalpha dependent pathway and that disruption of signaling in the absence of both PS1 and PS2 *results* in lower downstream activation of [Erk] . Positive_regulation EPHB2 HSPG2 18550646 1940625 In the present work utilizing opossum kidney cells , a model of renal proximal tubule , PTH stimulated [ERK] phosphorylation and membrane translocation of PKCalpha were *prevented* by inhibition of Src kinase , , and calcium entry . Positive_regulation EPHB2 HSPG2 19137008 2037780 it may function as an inhibitor for various types of dependent signaling as well as for [ERK] *activation* . Positive_regulation EPHB2 HSPG2 19747075 2168244 Furthermore , [ERK] phosphorylation and the mitogenic effect are partially *suppressed* by a inhibitor . Positive_regulation EPHB2 HSPG2 19747075 2168246 These data suggest that the mitogenic effect of CMS2MS2 on fibroblasts is independent of its proteolytic activity , *requires* [ERK] phosphorylation , and involves activation of . Positive_regulation EPHB2 HSPG2 20163623 2180720 These results indicate that the LPS induced phosphorylation of [ERK] in the chicken heterophils is *mediated* by , PKC and intracellular calcium , and the PMA stimulated phosphorylation is dependent on intracellular calcium ion and PKC . Positive_regulation EPHB2 HSPG2 21705626 2455775 In this study , we demonstrate that activity is *required* for SDF-1 to induce [ERK] activation , migration , and CXCR4 endocytosis in human T cells . Positive_regulation EPHB2 HSPG2 22981863 2688686 LAT independent [Erk] *activation* via complexes : GTPase independent Pak1 activation . Positive_regulation EPHB2 HSPG2 24696141 2938759 Inhibition of PAC1 receptor stimulated signaling by bisindoylmaleimide I also *attenuated* [ERK] phosphorylation , and direct PKC activation with phorbol ester increased ERK phosphorylation in a temperature dependent manner . Positive_regulation EPHB2 HTC1 18442977 1921083 Moreover , <5-HT(2A/C)> stimulation *triggered* the activation of extracellular signal regulated kinase ( [ERK] ) in dendritic processes . Positive_regulation EPHB2 HTC1 18455431 1921306 Biochemical evidence showed that 5-HT(1A) decreased , whereas <5-HT(2A/C)> *increased* the activation of [ERK] in an NMDA dependent manner . Positive_regulation EPHB2 HTC2 18442977 1921084 Moreover , <5-HT(2A/C)> stimulation *triggered* the activation of extracellular signal regulated kinase ( [ERK] ) in dendritic processes . Positive_regulation EPHB2 HTC2 18455431 1921307 Biochemical evidence showed that 5-HT(1A) decreased , whereas <5-HT(2A/C)> *increased* the activation of [ERK] in an NMDA dependent manner . Positive_regulation EPHB2 HTR1A 10727402 677859 Five criteria were shown to support a key role for ROS in the *activation* of [ERK] by the <5-HT(1A)> receptor . Positive_regulation EPHB2 HTR1B 10936173 720609 *Activation* of extracellular signal regulated kinase ( [ERK] ) and Akt by human serotonin <5-HT(1B)> receptors in transfected BE ( 2 ) -C neuroblastoma cells is inhibited by RGS4 . Positive_regulation EPHB2 HTR1B 11454948 837872 Both compounds caused complete inhibition of phosphorylation of [ERK] and a maximal 60 % inhibition of <5-HT1B> receptor *mediated* phosphorylation of Akt . Positive_regulation EPHB2 HTR2A 16737974 1585286 <5-HT2A> receptor *induces* [ERK] phosphorylation and proliferation through ADAM-17 tumor necrosis factor-alpha converting enzyme ( TACE ) activation and heparin bound epidermal growth factor-like growth factor ( HB-EGF ) shedding in mesangial cells . Positive_regulation EPHB2 HTR2A 16737974 1585288 In this study , we present multiple lines of evidence to support a critical role for heparin bound EGF ( epidermal growth factor ) -like growth factor ( HB-EGF ) and tumor necrosis factor-alpha converting enzyme ( TACE ) ( ADAM17 ) in the transactivation of EGF receptor (EGFR) , [ERK] phosphorylation , and cellular proliferation *induced* by the <5-HT(2A)> receptor in renal mesangial cells . Positive_regulation EPHB2 HTR2A 17210798 1709556 Although 5-hydroxytryptamine ( serotonin ) ( 5-HT ) , but not noradrenaline or dopamine , increased [ERK] *activation* and GDNF release via <5-HT2A> receptors , ketanserin , a 5-HT2A receptor antagonist , did not have any effect on the amitriptyline induced ERK activation . Positive_regulation EPHB2 HTR2A 18758753 1985625 The objectives of the study are to identify subtype of the 5-HT(2) receptor involved , to establish whether [ERK] ( 1/2 ) phosphorylation is a *result* of <5-HT(2)> mediated transactivation of epidermal growth factor (EGF) receptors ( EGFRs ) , and to determine signaling pathways up- and downstream of ERK ( 1/2 ) . Positive_regulation EPHB2 HTR2B 18758753 1985624 Fluoxetine mediated <5-HT2B> receptor stimulation in astrocytes *causes* EGF receptor transactivation and [ERK] phosphorylation . Positive_regulation EPHB2 HTR4 17377064 1741505 The <5-HT(4)R> mediated [ERK] *activation* seemed to be dependent on Src tyrosine kinase and yet totally independent of beta-arrestin . Positive_regulation EPHB2 HTR4 17377064 1741506 Immunocytofluorescence revealed that [ERK] *activation* by <5-HT(4)R> was restrained to the plasma membrane , whereas p-Src colocalized with the receptor and carried on even after endocytosis . Positive_regulation EPHB2 HTT 22334892 2554016 In *response* to mutant , [ERK] is activated and directs a protective transcriptional response and inhibits caspase activation . Positive_regulation EPHB2 IAPP 22129618 2548522 *induced* [ERK] phosphorylation ( pERK ) was investigated by immunohistochemistry in brain sections containing the AP. pERK positive AP neurons were double stained for the calcitonin 1a/b receptor , which is part of the functional amylin-receptor . Positive_regulation EPHB2 ICAM1 17849175 1842821 In cultured ECs , Fg binding to and to alpha(5)beta(1) integrin , *caused* phosphorylation of [ERK] . Positive_regulation EPHB2 ICAM1 22972429 2706280 HDL isolated from ELKO , ELTg , and WT mice inhibited expression of , angiotensin II-induced *activation* of [Erk] , and growth of cultured vascular smooth muscle cells , whereas EL expression itself did not affect cell migration or growth . Positive_regulation EPHB2 ICAM4 22147898 2548634 These results demonstrate that [ERK] activation *induces* phosphorylation of cytoskeletal proteins and the adhesion molecule , promoting SS RBC adhesion to the endothelium . Positive_regulation EPHB2 ICOS 12594849 1061097

*mediated* activation of JNK , but not [ERK] or p38 , is partially dependent on the expression of CD4 by the cells , whereas H4/ICOS costimulation is partially independent on CD28 expression . Positive_regulation EPHB2 ID1 17426247 1723970 Finally , *induced* tube formation in human umbilical endothelial cells , which also required active [ERK] signaling . Positive_regulation EPHB2 IFIT1 11164895 763151 To determine if ( Lck ) was *involved* in calcium induced [ERK] activation , we stimulated the p56 ( Lck ) negative Jurkat cell derivatives , J.CaM1.6 and J.CaM1/Rep3 , with ionomycin . Positive_regulation EPHB2 IFITM1 19499152 2091873 Our study showed the interaction of IFITM1- and CAV-1 enhanced CAV-1 's inhibitory effect on ERK activation , whereas the did not *activate* [ERK] directly . Positive_regulation EPHB2 IFITM1 20847954 2319254 Activation of CD147 with cyclophilin a *induces* the expression of through [ERK] and PI3K in THP-1 cells . Positive_regulation EPHB2 IFNB1 10684111 407134 Similarly , in agreement with a very recent report from David , M et al in NIH , in which they indicated that forskolin ( 30 mumol/L ) inhibited *stimulated* [ERK] activity by U 266 cells ( J. Biol. Chem. 271 : 4585-4588 1996 ) , we found that the levels of phosphorylations of Raf-1 and ERK1 and ERK2 were declined when forskolin ( 30 mumol/L ) was added to macrophages for 20 min at 37 degrees C prior to the stimulation by LPS and PMA . Positive_regulation EPHB2 IFNB1 19140219 2053881 Pretreatment of hepatocytes and NPCs with HBV-Met cells supernatants , HBsAg , HBeAg , or HBV virions almost completely abrogated TLR induced antiviral activity , which correlated with suppression of production and subsequent interferon stimulated gene induction as well as suppressed *activation* of interferon regulatory factor 3 (IRF-3) , nuclear factor kappa B (NF-kappaB) , and extracellular signal regulated kinase ( [ERK] ) 1/2 . Positive_regulation EPHB2 IFNG 10601128 574186 Tumor necrosis factor-alpha (TNF-alpha) alone can induce extracellular signal regulated kinase ( ERK ) , p38 MAPK , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas can *induce* only [ERK] . Positive_regulation EPHB2 IFNG 12023055 943501 In contrast , *activated* only [ERK] after 6 h of stimulation and did not alter the activity of p38 and JNK . Positive_regulation EPHB2 IFNG 12929133 1132149 PMA and synergistically *enhanced* activity of NF-kappaB , but not [ERK] . Positive_regulation EPHB2 IFNG 16091294 1460697 Sodium butyrate significantly repressed the phosphorylation of [ERK] *induced* by , but had little effect on that induced by LPS . Positive_regulation EPHB2 IFNG 16484229 1541213 *enhanced* lipopolysaccharide (LPS) induced [ERK] and JNK phosphorylation but had no effect on LPS induced NF-kappaB activation . Positive_regulation EPHB2 IFNG 17255201 1725197 Prolactin *induced* phosphorylation of JAK2 and [ERK] , whereas induced phosphorylation of JAK1 , JAK2 , and p38 MAPK . Positive_regulation EPHB2 IFNG 17363736 1760138 *induced* STAT1 activation , via [MEK/ERK] and MyD88/TRAF6 , and inhibition of STAT1 reduced B7-H1 expression . Positive_regulation EPHB2 IFNG 19508391 2108591 LPS + *stimulated* phosphorylation of [ERK] , JNK and Jak2 , and degradation of IkappaB , but only Jak2 phosphorylation was sensitive to tripterine ( 50-200 nM ) . Positive_regulation EPHB2 IFNG 20424383 2247157 In this study , alpha-viniferin at 3 - 10 microM dose-dependently inhibited interferon (IFN)-gamma induced Ser ( 727 ) phosphorylation of the signal transducer and activation of transcription-1 ( STAT-1 ) , a pivotal transcription factor controlling IFN-gamma targeted genes , in RAW 264.7 macrophages , and also induced *activation* of the extracellular signal regulated kinase ( [ERK] ) -1 , a protein kinase upstream of the Ser ( 727 ) phosphorylation of STAT-1 . Positive_regulation EPHB2 IFNG 9233612 445083 The *requirement* for [ERK] signaling for maximal synthesis could nevertheless be demonstrated in both populations by blockade with the inhibitor PD98509 . Positive_regulation EPHB2 IFNL1 18830264 2000844 Our data also show that *induces* phosphorylation of STAT1 , STAT3 and [Erk] . Positive_regulation EPHB2 IGF1 10347117 616717 Insulin and IGF-1 induced 70-kd S6 kinase phosphorylation in HSC , whereas only *induced* [ERK] phosphorylation . Positive_regulation EPHB2 IGF1 10807918 708052 Cross talk between IGF-1 and EGF receptors is mediated through an autocrine mechanism involving matrix metalloprotease dependent release of heparin binding EGF (HB-EGF) , because mediated [ERK] *activation* is inhibited both by [ Glu ( 52 ) ] Diphtheria toxin , a specific inhibitor of HB-EGF , and the metalloprotease inhibitor 1,10-phenanthroline . Positive_regulation EPHB2 IGF1 10872812 707090 While the IGF-I induced activation of PKB/Akt was inhibited by PI3-K inhibitor LY294002 but not by MEK inhibitor PD98059 , the *activation* of both MEK and [ERK] by was inhibited by both . Positive_regulation EPHB2 IGF1 10873673 708599 *stimulated* polyphosphoinositide turnover , translocation of protein kinase C ( PKC ) isoforms ( alpha , epsilon , and delta ) from the soluble to the particulate fraction , activation of phospholipid dependent and Ca ( 2+ ) - , phospholipid dependent PKC , and activation of the [extracellular regulated kinase (ERK)] . Positive_regulation EPHB2 IGF1 11262401 818802 Activation of AMPK by AICAR in NIH-3T3 cells resulted in drastic inhibitions of Ras , Raf-1 , and [Erk] activation *induced* by . Positive_regulation EPHB2 IGF1 11262401 818816 Expression of an antisense RNA for the AMPK catalytic subunit decreased the AMPK activity and significantly diminished the AICAR effect on induced Ras activation and the subsequent [Erk] *activation* , indicating that its effect is indeed mediated by AMPK . Positive_regulation EPHB2 IGF1 11279003 802965 In C2C12 myoblast cells , and basic fibroblast growth factor (bFGF) *activate* [MAPK/Erk] , and both growth factors promote myoblast proliferation . Positive_regulation EPHB2 IGF1 11287604 800197 Stimulation of Swiss 3T3 cells with *caused* rapid nuclear translocation of activated [ERK] and concurrently induced phosphorylation of nuclear PLC beta1 , which was completely blocked by the MEK inhibitor PD 98059 . Positive_regulation EPHB2 IGF1 11420298 830582 Thus , PI 3 kinase and [ERK] coordinately *mediate* the transcriptional regulatory effects of in cardiac muscle cells . Positive_regulation EPHB2 IGF1 11527089 853290 Both and VEGF produced a time- and concentration dependent *increase* in the activation of [ERK] . Positive_regulation EPHB2 IGF1 11594774 870073 [ERK] *activation* by insulin , , or PDGF was unaffected by the phosphatidylinositol 3-kinase inhibitor wortmannin but was abolished by the MEK inhibitor PD98059 . Positive_regulation EPHB2 IGF1 11673351 872735 was *followed* by a PI3K dependent phosphorylation of AKT and BAD and an MEK1 dependent phosphorylation of extracellular signal regulated kinase ( [ERK] ) 1 and ERK2 . Positive_regulation EPHB2 IGF1 12065632 954521 ( 25 ng/mL ) *caused* a rapid increase in MAP-kinase activity and [ERK] phosphorylation . Positive_regulation EPHB2 IGF1 12200236 982885 In contrast , no *activation* of extracellular signal regulated kinase ( [ERK] ) 1/2 by was observed although basal phosphorylation was readily detectable . Positive_regulation EPHB2 IGF1 12385647 1034921 *induced* [ERK] phosphorylation was suppressed by butan-1-ol , but not butan-2-ol , whereas no effect of butanol was observed in IGF-I induced Akt activation in S1P(3) overexpressing Chinese hamster ovary cells . Positive_regulation EPHB2 IGF1 12385647 1034940 [ERK] *activation* by as well as S1P was dependent on Ras , but Akt activation by IGF-I was not dependent on Ras . Positive_regulation EPHB2 IGF1 12458213 1037595 Reconstitution of MEKK1 expression restored IRS-1 expression as well as *induced* [ERK] activation . Positive_regulation EPHB2 IGF1 12479095 1023939 [ Role of suppressor encoprotein PTEN in *induced* activation of [ERK] in endometrial carcinoma cells ] . Positive_regulation EPHB2 IGF1 12729801 1086720 *stimulated* activation of [MAPK/ERK] signaling in WM1341D cells was inhibited by U0126 , but a 33-fold higher dose of U0126 was needed to inhibit IGF-I stimulated cellular migration . Positive_regulation EPHB2 IGF1 12947030 1157987 and 4 ) through IGF1R *requires* both [ERK] and PI3K signaling for proliferation of near-term fetal sheep cardiomyocytes in vitro . Positive_regulation EPHB2 IGF1 14593113 1187320 Inhibition of the EGFR with function blocking monoclonal antibodies also specifically blocked *induced* [ERK] activation . Positive_regulation EPHB2 IGF1 15271882 1302443 The *induced* activation of [ERK] , but not that of Akt , is reportedly mediated by the transactivation of the epidermal growth factor receptor (EGFR) tyrosine kinase ( TK ) . Positive_regulation EPHB2 IGF1 15271882 1302447 We found that an oral carcinoma cell line overexpressing EGFR , Ca9-22 , exhibited *induced* activation of both Akt and [ERK] , but that only the latter was significantly decreased by a specific inhibitor of EGFR-TK , tyrphostin AG1478 . Positive_regulation EPHB2 IGF1 15271882 1302451 In this report we provide evidence for the existence in this cell line of a novel mechanism by which *induces* [ERK] activation in a manner that is dependent on the basal level of EGFR-TK activity , but is independent of receptor transactivation . Positive_regulation EPHB2 IGF1 15590974 1346133 We therefore compared mediated [ERK] *activation* in proliferating and hypertrophic chondrocytes . Positive_regulation EPHB2 IGF1 15590974 1346134 potently *induced* [ERK] activation in proliferating cells , but minimal ERK response was seen in hypertrophic cells . Positive_regulation EPHB2 IGF1 15772344 1384502 Stimulation of CGNs with *induced* an early and transient [ERK] activation but abrogated the appearance of late and sustained ERK . Positive_regulation EPHB2 IGF1 15801908 1432338 The MEK ( MAPK/ERK kinase ) inhibitors PD98059 and U0126 blocked *stimulated* [ERK] phosphorylation but did not block the phosphorylation of Akt and did not decrease proteoglycan synthesis . Positive_regulation EPHB2 IGF1 16284277 1525974 In contrast , the magnitude of BDNF stimulated extracellular signal regulated kinase ( ERK ) activation was found to be much greater than that of *stimulated* [ERK] , such that the difference in magnitude stimulated by BDNF in the presence and absence of IGF-1 did not reach statistical significance . Positive_regulation EPHB2 IGF1 16342423 1491884 Previously , the laboratory has reported that IGF1 activates PKC alpha in adult rat cardiomyocytes , and that PKC alpha activity is required for *dependent* [Erk/Erk2] activity and protein synthesis . Positive_regulation EPHB2 IGF1 16793775 1599604 Interestingly , the AKT and [ERK] *activation* by was normal in RIP-/- cells . Positive_regulation EPHB2 IGF1 16844778 1592165 However , Hsp90 inhibition has recently been reported to activate Akt and [Erk] and potentiate Akt activation *induced* by and insulin , raising the concern that clinical use of Hsp90 inhibitors might promote tumor progression under certain circumstances . Positive_regulation EPHB2 IGF1 16846747 1592269 We previously established that stimulation by of interleukin (IL)-8 expression in leukocytes *required* activation of [extracellular regulated kinase (ERK)] and basal activity of c-Jun N-terminal kinase (JNK) . Positive_regulation EPHB2 IGF1 17010943 1641168 markedly *increased* expression of integrin beta1 , [Erk] and Sox9 . Positive_regulation EPHB2 IGF1 17065200 1708945 Luteolin also inhibited the *induced* activation of EGFR and [MAPK/ERK] signaling . Positive_regulation EPHB2 IGF1 17303558 1718942 siRNA mediated suppression of beta-arrestin1 in human melanoma cells ablates *stimulated* [ERK] and prolongs the G1 phase of the cell cycle . Positive_regulation EPHB2 IGF1 17462533 1731644 In this study , we determined ( a ) whether and how *induces* transactivation of epidermal growth factor receptor (EGFR) in primary rat aortic VSMCs , ( b ) the contribution of EGFR to IGF-I stimulated activation of extracellular signal regulated kinase ( [ERK] ) and cell proliferation , and ( c ) the role of reactive oxygen species ( ROS ) in the cellular function . Positive_regulation EPHB2 IGF1 17478073 1848294 AICAR treatment ( 1mM , 36h ) increased *induced* progesterone secretion , StAR protein levels and decreased [ERK] phosphorylation in F1 granulosa cells . Positive_regulation EPHB2 IGF1 17478073 1848296 Adenovirus mediated expression of dominant negative AMPK totally reversed the effects of AICAR on *induced* progesterone secretion , StAR protein production and [ERK] phosphorylation in both F3/4 and F1 granulosa cells . Positive_regulation EPHB2 IGF1 18282556 1885259 In contrast , inhibitors of and platelet derived growth factor receptors , AG1024 and AG1295 , respectively , only slightly *reduced* [ERK] phosphorylation and had no effect on blood pressure in rats receiving leptin . Positive_regulation EPHB2 IGF1 18453753 1909246 LY294002 restored *induced* [ERK] phosphorylation . Positive_regulation EPHB2 IGF1 18463290 1910081 experiments with hBVR nuclear export signal (NES) and nuclear localization signal ( NLS ) mutants demonstrated its critical role in the nuclear localization of *stimulated* [ERK] for Elk1 activation . Positive_regulation EPHB2 IGF1 18489904 1921749 Simvastatin also inhibited *induced* activation of both [ERK] and Akt signaling and IGF-1 induced PC-3 cell proliferation . Positive_regulation EPHB2 IGF1 19179806 2038867 3 ) inhibition of calcineurin by cyclosporin A or FK506 down-regulated IRS-2 level , attenuating *induced* [ERK] and GSK-3beta pathways ; Positive_regulation EPHB2 IGF1 19217812 2086505 stimulation *increased* IGF-IR and [ERK] phosphorylation in adipocytes from AGA , but not from SGA children . Positive_regulation EPHB2 IGF1 19254730 2072493 *induced* phosphorylation of [extracellular related kinase (ERK)1/2] , MAP or ERK kinase (MEK)1/2 , and Akt , expression of cyclin D1 , and MC proliferation in cultured human MCs . Positive_regulation EPHB2 IGF1 19506077 2108366 3 ) Unlike PP2 , pNaKtide does not affect *induced* [ERK] activation in cardiac myocytes . Positive_regulation EPHB2 IGF1 19641719 1358726 *induced* an increase in phosphorylated extracellular signal regulated kinase 1/2 ( [ERK] ) , but did not change ERK protein content in cardiomyocytes . Positive_regulation EPHB2 IGF1 19762915 2158771 In normal human chondrocytes , *initiated* a strong and sustained phosphorylation of IRS-1 ( Tyr-612 ) and Akt ( Ser-473 ) and transient [ERK] phosphorylation . Positive_regulation EPHB2 IGF1 20371701 2261672 The aim of the present study was to investigate *stimulated* [ERK] signaling regulating P450scc gene expression in the immortalized porcine granulosa cell line JC-410 . Positive_regulation EPHB2 IGF1 20962017 2369556 To study the functional effect of the IGF1R gene mutation on IGF-I signaling , total IGF1R protein expression , and *dependent* Akt and [ERK] phosphorylation were assessed by Western blotting . Positive_regulation EPHB2 IGF1 21389330 2438238 The present study describes for the first time in a nonmammalian species that the [MAPK/ERK] and PI3K/Akt are *activated* by exogenous circulating , as well as showing that the MAPK/ERK pathway activation is modulated by the nutritional status . Positive_regulation EPHB2 IGF1 21389330 2438257 Together , these results suggest that the nutritionally managed could be *regulating* the activation of the [MAPK/ERK] and the PI3K/Akt signaling pathways differentially according to the nutritional status , triggering different effects in growth parameters and therefore contributing to somatic growth in fish . Positive_regulation EPHB2 IGF1 22305966 2570960 While PKC? exhibited negative regulation on AKT phosphorylation it did not alter the *induced* [ERK] phosphorylation . Positive_regulation EPHB2 IGF1 23402816 2787089 In addition , pretreatment with MK-0646 decreased the *induced* phosphorylation of IGF1R , AKT and [ERK] . Positive_regulation EPHB2 IGF1 23639626 2800414 By `` working upwards '' from mTOR , we observed that TCDD inhibited endogenous and *induced* AKT and [ERK] activation by interfering with tyrosine phosphorylation of insulin receptor substrate 1 . Positive_regulation EPHB2 IGF1 23650573 2714287 In HEK293 cells , IGF-1R signaling pathways are activated in *response* to , which induces obvious phosphorylations of receptor tyrosine and Akt , [ERK] . Positive_regulation EPHB2 IGF1 8058064 268079 Zymography of immunoprecipitated ERKs in myelin basic protein (MBP) containing polyacrylamide gels demonstrated dose dependent induction of ERK-1 and -2 activity by IGF-1 in GC cells with maximal activity occurring at 6 min. *induced* [ERK] activity in WT-transfected cells was up to 80-fold basal and 4-fold that observed in GC cells . Positive_regulation EPHB2 IGF1 8058064 268082 Forskolin ( 50 microM ) , isobutylmethylxanthine ( 0.5 mM ) , and forskolin/isobutylmethylxanthine in combination attenuated *induced* [ERK] activity in WT cells by 54 , 55 , and 75 % respectively . Positive_regulation EPHB2 IGF1 8941662 399292 However , [ERK] was also *activated* by PDGF , , and IL-6 . Positive_regulation EPHB2 IGF1 9683541 521438 Western analysis confirmed that [ERK] was strongly *activated* by PDGF-BB and PMA but not by . Positive_regulation EPHB2 IGF1 9852124 554614 The time course of Shc tyrosine phosphorylation parallels the time course of *stimulated* activation of extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 IGF1R 14657000 1202027 We investigated this crosstalk under different conditions and found that both Akt and [ERK] activation induced by S1P , but not lysophosphatidic acid (LPA) , in HEY ovarian cancer cells *required* PDGFR but not epidermal growth factor receptor (EGFR) or ( IGFR ) . Positive_regulation EPHB2 IGF1R 18070930 1868049 The PPP induced [ERK] activation *requires* because PPP is not able to induce ERK phosphorylation in IGF-1R negative cells or in cells in which the receptor is knocked down by small interfering RNA . Positive_regulation EPHB2 IGF1R 21878657 2501134 In both the cell lines , *induced* [Erk] , but not Akt , activation was eliminated by gefitinib . Positive_regulation EPHB2 IGF1R 22441800 2612828 and IGF-2R activation each *resulted* in [ERK] signaling , but IGF-2R activation alone induced CaMKII signaling , resulting in hypertrophy of cardiomyocytes in the late gestation sheep fetus . Positive_regulation EPHB2 IGF1R 23041229 2698536 In summary 2-DG elicits *mediated* AMPK inactivation and Akt and [ERK] activation , which facilitates or restrain apoptosis , respectively . Positive_regulation EPHB2 IGF1R 23248036 2757909 Klotho is a tumor suppressor that , through the regulation of phosphorylation and subsequent *activation* of downstream Akt-p70S6K and [ERK] signaling , regulates HCC tumor cell proliferation , apoptosis , autophagy and invasion . Positive_regulation EPHB2 IGF2 15304095 1284511 These results suggest that *induces* COX-2 expression through the tyrosine [kinase-Src-ERK] and tyrosine kinase-PI3-kinase pathways , but not via p38 MAPK pathway , and that the basal JNK activity is required for the upregulation of COX-2 by IGF-II , as well . Positive_regulation EPHB2 IGF2 18463290 1910082 experiments with hBVR nuclear export signal (NES) and nuclear localization signal ( NLS ) mutants demonstrated its critical role in the nuclear localization of *stimulated* [ERK] for Elk1 activation . Positive_regulation EPHB2 IGF2 19506077 2108367 3 ) Unlike PP2 , pNaKtide does not affect induced [ERK] *activation* in cardiac myocytes . Positive_regulation EPHB2 IGF2 20371701 2261673 The aim of the present study was to investigate *stimulated* [ERK] signaling regulating P450scc gene expression in the immortalized porcine granulosa cell line JC-410 . Positive_regulation EPHB2 IGF2 22514330 2584299 This process depends on mediated [MEK/ERK] *activation* . Positive_regulation EPHB2 IGF2R 22441800 2612829 IGF-1R and activation each *resulted* in [ERK] signaling , but IGF-2R activation alone induced CaMKII signaling , resulting in hypertrophy of cardiomyocytes in the late gestation sheep fetus . Positive_regulation EPHB2 IGF2R 22514330 2584300 This process depends on *mediated* [MEK/ERK] activation . Positive_regulation EPHB2 IGFBP2 17102589 1661067 Loss of *inhibits* the ability of p53 to inhibit the activation of extracellular signal regulated kinase ( [ERK] ) 1 by IGF-I . Positive_regulation EPHB2 IGFBP2 25093489 2956954 Western blot analysis and immunofluorescence staining revealed that *promoted* [ERK] phosphorylation and nuclear translocation . Positive_regulation EPHB2 IGFBP2 25093489 2956955 Neutralisation or knockdown of the expression of integrin ß1 inhibited *induced* [ERK] activation , cell proliferation , and cell invasion . Positive_regulation EPHB2 IGFBP5 23417767 2764945 While recombinant *increased* [ERK] phosphorylation , cell proliferation , and the mRNA levels of collagen III , MMP2 , and MMP9 in fibroblasts , IGFBP5 increased c-Jun N-terminal kinase phosphorylation and induced apoptosis in cardiomyocytes . Positive_regulation EPHB2 IKBKB 11149911 780450 TNF-alpha mediated *activation* of [MEK/ERK] and EGR-1 can be blocked by adenoviral expression of a dominant negative mutant of , whereas the VEGF signaling pathway is unaffected . Positive_regulation EPHB2 IL10 12721296 1106483 The protein tyrosine phosphatase SHP-2 regulates *induced* [ERK] activation in fibroblasts . Positive_regulation EPHB2 IL10 12828555 1104988 The above findings suggest a unidirectional negative autocrine regulation of IL-12 by IL-10 in activated DCs and that activation of [ERK] *involves* the differential production of and IL-12 by activated DCs . Positive_regulation EPHB2 IL10 12913253 1129634 In addition , *induced* tyrosine (Tyr) phosphorylation of [Erk] , as well as serine ( Ser ) and Tyr phosphorylation of STAT-3 . Positive_regulation EPHB2 IL10 15563458 1375012 SHP-2 modulates *induced* Ca2+ flux and [ERK] activation via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL10 18178819 1856402 We show in this study that peritoneal macrophages from SCID mice having mutations in the catalytic subunit of DNA-protein kinase ( DNA-PKcs ) were almost completely defective in the production of and in [ERK] *activation* when treated with CpG-ODN . Positive_regulation EPHB2 IL10 19646904 2125313 Interleukin-10 production by Th1 cells requires *induced* STAT4 transcription factor and [ERK] MAP kinase activation by high antigen dose . Positive_regulation EPHB2 IL10 20854249 2346685 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL10 8830657 385516 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL10 9507015 491625 Requirements of focal adhesions and calcium fluxes for *induced* [ERK] kinase activation and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL11 12721296 1106484 The protein tyrosine phosphatase SHP-2 regulates induced [ERK] *activation* in fibroblasts . Positive_regulation EPHB2 IL11 15563458 1375013 SHP-2 modulates induced Ca2+ flux and [ERK] *activation* via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL11 19646904 2125314 Interleukin-10 production by Th1 cells requires induced STAT4 transcription factor and [ERK] MAP kinase *activation* by high antigen dose . Positive_regulation EPHB2 IL11 20854249 2346686 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL11 8830657 385517 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL11 9507015 491626 Requirements of focal adhesions and calcium fluxes for induced [ERK] kinase *activation* and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL12A 12828555 1104989 The above findings suggest a unidirectional negative autocrine regulation of IL-12 by IL-10 in activated DCs and that activation of [ERK] *involves* the differential production of IL-10 and by activated DCs . Positive_regulation EPHB2 IL12A 19688743 2175824 *Activation* of p38 MAP kinase , but not [ERK] or JNK , by either TCR-stimuli or and IL-18 is diminished in Gadd45b ( -/- ) CD8 ( + ) T cells , resulting in reduced production of IFN-gamma . Positive_regulation EPHB2 IL12B 12828555 1104990 The above findings suggest a unidirectional negative autocrine regulation of IL-12 by IL-10 in activated DCs and that activation of [ERK] *involves* the differential production of IL-10 and by activated DCs . Positive_regulation EPHB2 IL12B 18390747 1893338 Further investigations showed that IL-17A , IL-17F , and differentially *activated* the [ERK] , p38 MAPK , and NF-kappaB pathways . Positive_regulation EPHB2 IL12B 19688743 2175825 *Activation* of p38 MAP kinase , but not [ERK] or JNK , by either TCR-stimuli or and IL-18 is diminished in Gadd45b ( -/- ) CD8 ( + ) T cells , resulting in reduced production of IFN-gamma . Positive_regulation EPHB2 IL13 11709700 879828 In these cells , IL-4 or were shown to *activate* the Janus Kinases JAK1 and JAK2 , the transcription factor STAT6 , and the [ERK] and p38 mitogen activated protein kinases . Positive_regulation EPHB2 IL13 11956062 930904 Activation of IL-4Ralpha by or IL-4 *induced* signal transducer and activation of transcription-6 ( STAT6 ) , p42/ p44 [ERK] , p38 , and to a lesser extent , SAPK/JNK mitogen activated protein kinase phosphorylation . Positive_regulation EPHB2 IL13 12721296 1106485 The protein tyrosine phosphatase SHP-2 regulates *induced* [ERK] activation in fibroblasts . Positive_regulation EPHB2 IL13 15563458 1375014 SHP-2 modulates *induced* Ca2+ flux and [ERK] activation via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL13 17418380 1748724 [ERK] phosphorylation was *increased* by and IL-13+TGF-beta1 . Positive_regulation EPHB2 IL13 17418380 1748757 These increases occur as TGF-beta1 downregulates IL-13 induced phosphoinositide-3 kinase activation while leaving the positive effect of *induced* [ERK] on Smad signaling . Positive_regulation EPHB2 IL13 19646904 2125315 Interleukin-10 production by Th1 cells requires *induced* STAT4 transcription factor and [ERK] MAP kinase activation by high antigen dose . Positive_regulation EPHB2 IL13 20854249 2346687 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL13 8830657 385518 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL13 9507015 491627 Requirements of focal adhesions and calcium fluxes for *induced* [ERK] kinase activation and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL15 12721296 1106486 The protein tyrosine phosphatase SHP-2 regulates induced [ERK] *activation* in fibroblasts . Positive_regulation EPHB2 IL15 15563458 1375015 SHP-2 modulates induced Ca2+ flux and [ERK] *activation* via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL15 19646904 2125316 Interleukin-10 production by Th1 cells requires induced STAT4 transcription factor and [ERK] MAP kinase *activation* by high antigen dose . Positive_regulation EPHB2 IL15 20854249 2346688 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL15 8830657 385519 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL15 9507015 491628 Requirements of focal adhesions and calcium fluxes for induced [ERK] kinase *activation* and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL16 12721296 1106487 The protein tyrosine phosphatase SHP-2 regulates *induced* [ERK] activation in fibroblasts . Positive_regulation EPHB2 IL16 15563458 1375016 SHP-2 modulates *induced* Ca2+ flux and [ERK] activation via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL16 19646904 2125317 Interleukin-10 production by Th1 cells requires *induced* STAT4 transcription factor and [ERK] MAP kinase activation by high antigen dose . Positive_regulation EPHB2 IL16 20854249 2346689 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL16 8830657 385520 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL16 9507015 491629 Requirements of focal adhesions and calcium fluxes for *induced* [ERK] kinase activation and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL17A 15982617 1424779 Western blotting clearly demonstrated that p38 MAPK , JNK and p42/p44 [ERK] were *activated* by in HASMC . Positive_regulation EPHB2 IL17A 15982617 1424783 We found that *induces* activation of p38MAPK , JNK and [p42/p44ERK] in HASMC . Positive_regulation EPHB2 IL17A 18310510 1904180 HG induces phosphoinositide 3- kinase [ PI3K ; inhibited by adenoviral ( Ad ) .dominant negative ( dn ) PI3Kp85 ] , Akt ( inhibited by Ad.dnAkt1 ) , and [ERK] ( inhibited by PD-98059 ) activation and *induces* expression via PI3K -- > Akt -- > ERK dependent signaling . Positive_regulation EPHB2 IL17A 19910679 2162098 EGCG and ECG prevented *induced* phosphorylation of p38 MAPK and [ERK] in HGFs . Positive_regulation EPHB2 IL17A 21145111 2373156 In accordance with the enhanced expression of IL-23 p19 , stimulation *resulted* in rapid activation of Akt , p38 mitogen activated protein kinase (MAPK) , extracellular signal regulated kinase ( [ERK] ) 1/2 , c-Jun-N-terminal kinase (JNK) , nuclear factor-kappaB ( NF-?B ) , and activator protein-1 (AP-1) in hPDLFs . Positive_regulation EPHB2 IL17A 23192794 2704852 In isolated and cultured rat DRG neurons , *caused* rapid phosphorylation of protein kinase B and [ERK] , and it rapidly enhanced excitability . Positive_regulation EPHB2 IL17D 22069308 2528246 *activates* [ERK] and p38 MAPKs as well as Akt , STAT1 , STAT3 , and STAT6 in IEC . Positive_regulation EPHB2 IL18 12721296 1106488 The protein tyrosine phosphatase SHP-2 regulates induced [ERK] *activation* in fibroblasts . Positive_regulation EPHB2 IL18 15563458 1375017 SHP-2 modulates induced Ca2+ flux and [ERK] *activation* via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL18 17274000 1697349 *induced* phosphorylation of [ERK] and Akt , while IFN-gamma induced phosphorylation of p38 MAPK . Positive_regulation EPHB2 IL18 19646904 2125318 Interleukin-10 production by Th1 cells requires induced STAT4 transcription factor and [ERK] MAP kinase *activation* by high antigen dose . Positive_regulation EPHB2 IL18 19688743 2175826 *Activation* of p38 MAP kinase , but not [ERK] or JNK , by either TCR-stimuli or IL-12 and is diminished in Gadd45b ( -/- ) CD8 ( + ) T cells , resulting in reduced production of IFN-gamma . Positive_regulation EPHB2 IL18 20854249 2346690 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL18 8830657 385521 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL18 9507015 491630 Requirements of focal adhesions and calcium fluxes for induced [ERK] kinase *activation* and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL19 12721296 1106489 The protein tyrosine phosphatase SHP-2 regulates *induced* [ERK] activation in fibroblasts . Positive_regulation EPHB2 IL19 15563458 1375018 SHP-2 modulates *induced* Ca2+ flux and [ERK] activation via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL19 19646904 2125319 Interleukin-10 production by Th1 cells requires *induced* STAT4 transcription factor and [ERK] MAP kinase activation by high antigen dose . Positive_regulation EPHB2 IL19 20854249 2346691 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL19 8830657 385522 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL19 9507015 491631 Requirements of focal adhesions and calcium fluxes for *induced* [ERK] kinase activation and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL1A 10648566 662083 strongly *induced* [ERK] activation as well as NF-kappaB activation . Positive_regulation EPHB2 IL1A 10823834 714942 We determined if the association kinetics of the interleukin-1 receptor associated kinase ( IRAK ) colocalizes with FACs and the requirement for IRAK in *dependent* [ERK] activation . Positive_regulation EPHB2 IL1A 10823834 714943 Cells treated with latrunculin B or swinholide A , which caused a progressive depolymerization of actin filaments , showed a reduction or elimination of *induced* [ERK] activation , respectively . Positive_regulation EPHB2 IL1A 11083274 750485 Tumor necrosis factor alpha , , and IL-6 were the major *inducers* of [ERK] , JNK , and p38 MAPK activation in cultured human synovial cells . Positive_regulation EPHB2 IL1A 11546664 856567 The mitogen activated protein kinase (MAPK) kinase ( MEK ) inhibitors , PD-98059 and U-0126 , blocked *induced* [ERK] activation and partially attenuated cPLA(2)alpha phosphorylation and PGI ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation EPHB2 IL1A 12009331 940999 rapidly *induced* the activation of extracellular-signal regulated kinase ( [ERK] ) , protein 38 (p38) and c-Jun N-terminal kinase (JNK) MAPKs in the first-passage human femoral head OA chondrocytes . Positive_regulation EPHB2 IL1A 12020969 942716 Western blot analysis showed phosphorylated p38 and JNK in *activated* astrocytes , and phosphorylated [ERK] in both resting and activated cells . Positive_regulation EPHB2 IL1A 12632422 1067957 In chondrocyte monolayers , both basal and *stimulated* [ERK] activities were similarly elevated at 0.5 hours after medium change , diminishing by 74 % after 16 hours . Positive_regulation EPHB2 IL1A 12632422 1067958 [ERK] signaling in *response* to in chondrocyte monolayers exhibited a pattern that was distinct from that in other culture systems , suggesting that the extracellular matrix plays an important regulatory role in modulating the response to extracellular stimuli . Positive_regulation EPHB2 IL1A 12654926 1092227 We investigated the link between aberrant integrin expression , [Erk] *activation* , and expression of . Positive_regulation EPHB2 IL1A 12654926 1092230 Inhibition of transactivation blocked basal and TPA or *induced* [Erk] activation , but not IkappaBalpha degradation , and abolished increased IL-1alpha production in transgenic cells . Positive_regulation EPHB2 IL1A 12721296 1106502 *induced* [ERK] activation is markedly diminished in fibroblasts deprived of focal adhesions whereas activation of p38 and JNK is unaffected . Positive_regulation EPHB2 IL1A 12721296 1106503 Here we demonstrate that SHP-2 , a protein tyrosine phosphatase present in focal adhesions , modulates *induced* [ERK] activation and the transient actin stress fiber disorganization that occurs following IL-1 treatment in human gingival fibroblasts . Positive_regulation EPHB2 IL1A 12721296 1106504 Blocking anti-SHP-2 antibodies , electoporated into the cytosol of fibroblasts , inhibited *induced* [ERK] activation , actin filament assembly , and cell contraction , indicating a role for SHP-2 in these processes . Positive_regulation EPHB2 IL1A 12721296 1106505 In summary , our data indicate that SHP-2 , a focal adhesion associated protein , participates in *induced* [ERK] activation likely via an adaptor function . Positive_regulation EPHB2 IL1A 12901852 1118863 *activated* all three mitogen activated protein (MAP) kinase family members : p38 MAP kinase , [extracellular regulated kinases (ERK)] , and c-Jun amino-terminal kinases (JNK) . Positive_regulation EPHB2 IL1A 14519666 1147831 We conducted studies to elucidate which steps of cellular Ca2+ handling are affected by focal adhesions and by which mechanisms focal adhesions modulate *induced* Ca2+ signals and [ERK] activation in human gingival fibroblasts . Positive_regulation EPHB2 IL1A 14519666 1147833 Focal adhesions were also required for Ca2+ entry through store operated channels and for induced [ERK] *activation* . Positive_regulation EPHB2 IL1A 15123616 1266632 Our functional studies show can *activate* JNK but not the [ERK] or the p38 MAP kinases , whereas its close homolog , TIGIRR , can not activate JNK . Positive_regulation EPHB2 IL1A 15563458 1375029 Because the non-receptor tyrosine phosphatase Src homology 2 domain containing protein tyrosine phosphatase-2 ( SHP-2 ) is enriched in focal adhesions and *induced* [ERK] activation requires increased Ca ( 2+ ) , we determined whether SHP-2 modulates IL-1 induced Ca ( 2+ ) signaling . Positive_regulation EPHB2 IL1A 15563458 1375031 however , these associations and *induced* [ERK] activation dissipated after cells were plated on non-integrin substrates . Positive_regulation EPHB2 IL1A 15728661 1396301 Mitochondrial function is a critical determinant of *induced* [ERK] activation . Positive_regulation EPHB2 IL1A 15728661 1396304 Here , we examined the impact of cell energetics and mitochondrial function on the regulation of induced Ca2+ signals and [ERK] *activation* in human gingival fibroblasts , cells that are important targets for IL-1 induced destruction of extracellular matrix in inflamed connective tissues . Positive_regulation EPHB2 IL1A 15728661 1396306 Inhibition of cellular energetics by selective depolarization of mitochondria blocked Ca2+ uptake and almost completely abolished *induced* cytosolic Ca2+ signals and [ERK] activation . Positive_regulation EPHB2 IL1A 15780952 1385416 *activated* [ERK] phosphorylation and PD98059 greatly inhibited both COX-2 mRNA expression and PGE ( 2 ) production induced by IL-1alpha in PDL cells . Positive_regulation EPHB2 IL1A 16181786 1462065 Western blotting revealed that *activated* p38 MAPK and JNK/SAPK , but not [ERK] , in Sertoli cells from 8- or 9-day-old rat . Positive_regulation EPHB2 IL1A 16436473 1554459 Taken together , we have outlined a novel transduction pathway implicating PKC-delta as a critical component of the *dependent* activation of [ERK] in VSM cells . Positive_regulation EPHB2 IL1A 16905534 1625823 This process involves the proteintyrosine phosphatase SHP-2 , which is critical for IL-1 induced phosphorylation of phospholipase Cgamma1 , thereby enhancing *induced* Ca2+ release and [ERK] activation . Positive_regulation EPHB2 IL1A 17202147 1702409 *induced* [ERK] activation appears to be independent of HSP27 . Positive_regulation EPHB2 IL1A 17907188 1812713 PD184352 reduced *induced* [p-ERK] levels in human RA synovial fibroblasts . Positive_regulation EPHB2 IL1A 17907188 1812714 We observed *induced* [p-ERK] in the synovial lining , subsynovial vasculature , and articular chondrocytes . Positive_regulation EPHB2 IL1A 18068103 1846983 ERK1/2 was constitutively activated in A375-6 cells , and further *augmented* [ERK] activation . Positive_regulation EPHB2 IL1A 20472558 2283337 Interactions between SHP-2 and PTPalpha , recruitment of SHP-2 to focal adhesions , *induced* [ERK] activation , and MMP3 expression were all blocked by point mutations in the phosphatase domains of PTPalpha . Positive_regulation EPHB2 IL1A 20854249 2346692 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , interleukin-1ß ( *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL1A 20881435 2407013 TGF-ß2 markedly inhibited *induced* phosphorylation of [ERK] , which was necessary for the cytokine response . Positive_regulation EPHB2 IL1A 21185827 2385974 *increased* [ERK] activity , which was not affected by docetaxel . Positive_regulation EPHB2 IL1A 21679050 2562293 However , transfection with a dominant negative form of the Ras protein ( Ras ( N17 ) ) inhibited the [ERK] activation and MMP-9 and -13 mRNA expressions *induced* by , which supported the involvement of ERK signalling in IL-1ß induced MMP-9 and -13 expressions . Positive_regulation EPHB2 IL1A 21679050 2562298 Treatment with luteolin effectively inhibited the *induced* [ERK] activation in dose dependent manner . Positive_regulation EPHB2 IL1A 21697093 2465464 SIRT1 activation promotes induction of [ERK] and p38 kinase activities , but not JNK , in *response* to . Positive_regulation EPHB2 IL1A 21719512 2483866 In connective tissue cells , *induced* [ERK] activation leading to matrix metalloproteinase (MMP)-3 expression is dependent on cooperative interactions between focal adhesions and the endoplasmic reticulum ( ER ) . Positive_regulation EPHB2 IL1A 22214865 2624086 As a result , in the presence of PPS existence , *induced* phosphorylation of p38 and [ERK] were certainly inhibited , while JNK phosphorylation was not affected . Positive_regulation EPHB2 IL1A 22237943 2591934 We assessed production of NO , synthesis of and *activation* of [ERK] , JNK and NF-?B signaling pathways by Western blot , in primary rat glial cultures exposed to SR ligands ( fucoidan and Poly I ) , LPS + IFN? (LI) , and Aß . Positive_regulation EPHB2 IL1A 23145787 2722864 This association enables PLC?1 recruitment to focal adhesions and is required for Ras signalling , [ERK] *activation* and MMP-3 release downstream of stimulation . Positive_regulation EPHB2 IL1A 23680829 2819333 ERK specific inhibitor U0126 significantly inhibited *induced* [ERK] activation . Positive_regulation EPHB2 IL1A 23968970 2850478 However , intrahippocampal injection of a-MSH prevented the effect on [ERK] phosphorylation and BDNF expression *induced* by after contextual fear conditioning . Positive_regulation EPHB2 IL1A 24431281 2901342 *mediated* activation of [ERK] , which regulates IL-10 expression , was increased in Fas-deficient mouse macrophages . Positive_regulation EPHB2 IL1A 24613844 2930015 Notably , increased the mRNA expression and subsequent secreted levels of MMP-7 protein and *enhanced* the phosphorylation of p38 and [ERK] mitogen activated protein kinases . Positive_regulation EPHB2 IL1A 24627146 2930221 The *induced* [ERK] and p38 phosphorylation , and AP-1 DNA binding were attenuated in the presence of pirfenidone . Positive_regulation EPHB2 IL1A 9507015 491643 Calcium depletion abolished *induced* calcium uptake , [ERK] activation , and c-fos expression . Positive_regulation EPHB2 IL1A 9507015 491644 The focal adhesion dependence of *induced* [ERK] activation and c-fos expression could be circumvented in cells plated on poly-L-lysine by simultaneous incubation with IL-1 and the calcium ionophore ionomycin . Positive_regulation EPHB2 IL1B 10807932 708058 SB203580 did not affect *induced* [ERK] activation , yet enhanced IL-1beta induced JNK activation approximately 2-fold . Positive_regulation EPHB2 IL1B 11179516 784771 We found that IL-1 beta induced ERK phosphorylation , PD153035 and MEK inhibitor PD98059 blocked *induced* [ERK] activity . Positive_regulation EPHB2 IL1B 11509539 848311 Stimulation of VSM cells with significantly ( P < 0.05 ) *increased* superoxide production , [ERK] activation , and MMP-9 induction . Positive_regulation EPHB2 IL1B 11509539 848315 In addition , pretreatment of VSM cells with a specific ERK pathway inhibitor , PD-98059 , or DETA NONOate inhibited *stimulated* [ERK] activation and MMP-9 induction . Positive_regulation EPHB2 IL1B 11698472 878093 *induced* phosphorylation of [ERK] and JNK as well as p38 MAPK in human endothelial cells . Positive_regulation EPHB2 IL1B 11709424 879801 *stimulated* biphasic [ERK] activation in vascular smooth muscle ( VSM ) cells , a transient activation that reached a maximum at 15 min and declined to baseline levels within 1 h , and a second phase of sustained ERK activation lasting up to 8 h . Positive_regulation EPHB2 IL1B 11742864 887445 These data suggest that [ERK] activity is *required* for persistent NF-kappaB activation by that is necessary for iNOS gene expression . Positive_regulation EPHB2 IL1B 11854442 913953 Furthermore , Ro 31-8220 inhibited *induced* p38 phosphorylation but not [ERK] phosphorylation . Positive_regulation EPHB2 IL1B 12391274 1007550 These results indicate that in human pulmonary epithelial cells , *activates* [ERK] or p38 to induce COX-2 production , which in turn induces MUC2 and MUC5AC production . Positive_regulation EPHB2 IL1B 14612947 1163427 The PLC-PKC cascade is required for *dependent* [Erk] and Akt activation : their role in proliferation . Positive_regulation EPHB2 IL1B 14612947 1163432 Pharmacological inhibition of the PLC-PKC cascade by using specific inhibitor for PLC-gamma ( U73122 ) and PKC ( GFX ) strongly inhibited *induced* [Erk] and Akt activation . Positive_regulation EPHB2 IL1B 14612947 1163445 Taken together , our results suggest that a SHPS-1-PLC-gamma complex activate the PLC-PKC cascade , which is required for the activation of *dependent* [Erk] and Akt signalings and cell proliferation . Positive_regulation EPHB2 IL1B 15001568 1236968 The inhibitory effect of angiotensin II on iNOS expression was associated with a down-regulation of the sustained *activation* of extracellular signal regulated kinase ( [ERK] ) and NF-kappaB by , whereas the effect on VCAM-1 was independent of ERK activation . Positive_regulation EPHB2 IL1B 15220194 1264504 Similarly , 1 micromol/l of the mitogen activated protein kinase/ERK kinase 1/2 inhibitor PD098059 or 1 micromol/l of the l-type Ca ( 2+ ) channel blocker nimodipine prevented glucose- and *induced* [ERK] activation , beta-cell apoptosis , and impaired function . Positive_regulation EPHB2 IL1B 15326113 1287294 Inhibition of the *induced* activation of [ERK] and JNK may contribute to these effects of dexamethasone . Positive_regulation EPHB2 IL1B 15477222 1342480 SP600125 ( 20 microM ) had no effect on *induced* [ERK] and p38 phosphorylation . Positive_regulation EPHB2 IL1B 15831571 1417979 Activation of p38 and [ERK] in *response* to was also dependent on L-type Ca ( 2+ ) influx . Positive_regulation EPHB2 IL1B 16250012 1508400 also *induced* activation of [ERK] and recruitment of phospho-ERK to focal complexes/adhesions . Positive_regulation EPHB2 IL1B 16250012 1508402 Depletion of SHP-2 by siRNA or by homologous recombination markedly altered *induced* [ERK] activation and maturation of focal adhesions . Positive_regulation EPHB2 IL1B 16272352 1479492 PGE2 also blocked *stimulated* [ERK] activation , and the ERK inhibitor , PD98059 , mimicked PGE2 in blocking p65 , but enhancing p50 nuclear translocation , suggesting that the effects of PGE2 on p65 and p50 are mediated via effects on ERK . Positive_regulation EPHB2 IL1B 16528573 1549437 In INS-1E and beta-TC3 cells , expression of Gadd45b inhibited *induced* activation of JNK and [ERK] , but augmented IL-1beta mediated p38 activity . Positive_regulation EPHB2 IL1B 16822942 1638578 In cultured rat VSMCs , *activated* [ERK] and induced degradation of both IkappaBalpha and IkappaBbeta , which was associated with nuclear translocation of both ribosomal S6 kinase (RSK)1 and NF-kappaB p65 . Positive_regulation EPHB2 IL1B 16959849 1639693 *caused* an increase in the phosphorylation of [ERK] , but not p38MAPK or c-Jun N-terminal kinase . Positive_regulation EPHB2 IL1B 17015748 1629896 *activated* NF-kappaB but not [ERK] or p38 . Positive_regulation EPHB2 IL1B 17574271 1792283 In vitro , Ro26-2198 inhibited *induced* [ERK] activation and COX-2 induction and decreased HCA-7 cell proliferation . Positive_regulation EPHB2 IL1B 18171908 1883121 S1P significantly inhibited *induced* persistent activation of extracellular signal regulated kinase ( [ERK] ) but had no effect in Ca ( 2+ ) -depleted conditions . Positive_regulation EPHB2 IL1B 18297103 1891655 Functionally blocking Ca ( 2+ ) release from endoplasmic reticulum with ryanodine or 2-aminoethoxydiphenylborane ( 2-APB ) , inhibiting calmodulin (CaM) activity with N- ( 6-aminohexyl ) -5-chloro-1-naphthalenesulphonamide hydrochloride ( W7 ) or MAPK kinase activity with 1,4-diamino-2,3-dicyano-1,4-bis [ 2-aminophenylthiol ] butadiene ( U0126 ) downregulated *induced* [ERK] activation as well as cell proliferation . Positive_regulation EPHB2 IL1B 19542681 2099225 Furthermore , ITZ-1 selectively inhibited *induced* [ERK] activation without affecting p38 kinase and JNK activation , which may account for its selective inhibition of MMP-13 production . Positive_regulation EPHB2 IL1B 20100175 2219234 Dexamethasone and RU24858 both reduced *induced* [ERK] phosphorylation and increased MKP-1 ( MAPK phosphatase-1 ) expression . Positive_regulation EPHB2 IL1B 20145375 2280999 Angiotensin II augmented the *induced* phosphorylation of [ERK] but not NF-kappaB and JNK . Positive_regulation EPHB2 IL1R1 10545489 564510 Interruption of TCR- or *stimulated* [ERK] cascade by PD-98059 , a specific inhibitor of MAP/ERK kinase (MEK) , resulted in partial suppression of nuclear factor of activated T cells activation and in complete inhibition of IL-1 stimulated NFkappaB activation . Positive_regulation EPHB2 IL2 10843677 700106 *induced* [ERK] activation within 5 min. Treatment of NK cells with a specific inhibitor of MKK1/2 , PD98059 , during the IL-2 stimulation blocked in a dose dependent manner each of four sequelae , with inhibition of lymphokine activated killing induction being least sensitive to MKK/ERK pathway blockade . Positive_regulation EPHB2 IL2 11331873 808927 A tyrosine mutant of SOCS-3 still blocks STAT phosphorylation , but also strongly inhibits *dependent* activation of [ERK] and cell proliferation . Positive_regulation EPHB2 IL2 12681450 1077443 This report shows that the PI3K inhibitors LY294002 and wortmannin block *activation* of MEK and [ERK] by in primary human T cells . Positive_regulation EPHB2 IL2 12721296 1106490 The protein tyrosine phosphatase SHP-2 regulates induced [ERK] *activation* in fibroblasts . Positive_regulation EPHB2 IL2 15170389 1280326 Expression of the Gab2 Tyr-614 -- > Phe ( Y614F ) mutant , defective in SHP-2 association , prevents ERK ( extracellular-signal regulated kinase ) activation and expression of a luciferase reporter plasmid driven by the c-fos SRE ( serum response element ) , indicating that interaction of SHP-2 with Gab2 is required for [ERK] activation in *response* to . Positive_regulation EPHB2 IL2 15563458 1375019 SHP-2 modulates induced Ca2+ flux and [ERK] *activation* via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL2 19646904 2125320 Interleukin-10 production by Th1 cells requires *induced* STAT4 transcription factor and [ERK] MAP kinase activation by high antigen dose . Positive_regulation EPHB2 IL2 20201035 2248974 In conclusion , an increase of cytoplasmic free zinc is required for *induced* [ERK] signaling and proliferation of T cells . Positive_regulation EPHB2 IL2 20461527 2301015 The pharmacological inhibition of *induced* [MEK/ERK] or JAK/STAT cascades suppressed the IL-2 induced proliferation and reduced the functional and protein expressions of Na , K-ATPase . Positive_regulation EPHB2 IL2 20854249 2346693 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL2 22123847 2542179 Instead , Nef triggers Lck dependent *activation* of TGN associated [Ras-Erk] signaling to promote the production of the T lymphocyte survival factor and to enhance virus spread . Positive_regulation EPHB2 IL2 22634617 2615104 Indeed , *potentiated* [ERK] activation and subsequent BACH2 and IRF8 downregulation , sustaining BLIMP1 expression , the master regulator for PC differentiation . Positive_regulation EPHB2 IL2 23851689 2825152 Ndfip1 and IL-2 have a similar expression pattern , and , following TCR stimulation , expression of both Ndfip1 and *requires* the activity of NFAT and [Erk] . Positive_regulation EPHB2 IL2 8830657 385523 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL2 8921960 396891 This possibility was supported by studies with the MEK inhibitor PD098059 , which had no selective effect on CT6 proliferation induced by IL-2 as compared with IL-7 , although the drug completely inhibited [MAP/Erk] phosphorylation *induced* by . Positive_regulation EPHB2 IL2 9507015 491632 Requirements of focal adhesions and calcium fluxes for induced [ERK] kinase *activation* and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL20 12721296 1106491 The protein tyrosine phosphatase SHP-2 regulates *induced* [ERK] activation in fibroblasts . Positive_regulation EPHB2 IL20 15563458 1375020 SHP-2 modulates *induced* Ca2+ flux and [ERK] activation via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL20 19646904 2125321 Interleukin-10 production by Th1 cells requires induced STAT4 transcription factor and [ERK] MAP kinase *activation* by high antigen dose . Positive_regulation EPHB2 IL20 20854249 2346694 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL20 8830657 385524 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL20 9507015 491633 Requirements of focal adhesions and calcium fluxes for induced [ERK] kinase *activation* and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL21 12721296 1106492 The protein tyrosine phosphatase SHP-2 regulates induced [ERK] *activation* in fibroblasts . Positive_regulation EPHB2 IL21 15563458 1375021 SHP-2 modulates induced Ca2+ flux and [ERK] *activation* via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL21 19646904 2125322 Interleukin-10 production by Th1 cells requires *induced* STAT4 transcription factor and [ERK] MAP kinase activation by high antigen dose . Positive_regulation EPHB2 IL21 20854249 2346695 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL21 22450323 2583023 *activates* the JAK-STAT , [ERK] , and PI3K pathways . Positive_regulation EPHB2 IL21 8830657 385525 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL21 9507015 491634 Requirements of focal adhesions and calcium fluxes for induced [ERK] kinase *activation* and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL22 12721296 1106475 The protein tyrosine phosphatase SHP-2 regulates *induced* [ERK] activation in fibroblasts . Positive_regulation EPHB2 IL22 15563458 1375004 SHP-2 modulates *induced* Ca2+ flux and [ERK] activation via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL22 19646904 2125305 Interleukin-10 production by Th1 cells requires *induced* STAT4 transcription factor and [ERK] MAP kinase activation by high antigen dose . Positive_regulation EPHB2 IL22 20854249 2346677 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL22 21897855 2478156 overexpression promotes production of inflammatory cytokines such as IL-1ß and IL-10 and *stimulates* [ERK] phosphorylation in adipose tissue . Positive_regulation EPHB2 IL22 24517997 2938262 *increased* MAP3K8 phosphorylation through IL-22R1 , followed by the induction of [MEK-ERK] , JNK-c-Jun , and STAT3 signaling pathways . Positive_regulation EPHB2 IL22 24937671 2952273 The effects of *induced* STAT3 and [ERK] signalling on invasive ability of gastric cancer cells were examined using a small interfering RNA system and specific inhibitors . Positive_regulation EPHB2 IL22 8830657 385508 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL22 9507015 491617 Requirements of focal adhesions and calcium fluxes for *induced* [ERK] kinase activation and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL23A 18390747 1893337 Further investigations showed that IL-17A , IL-17F , and differentially *activated* the [ERK] , p38 MAPK , and NF-kappaB pathways . Positive_regulation EPHB2 IL24 12721296 1106473 The protein tyrosine phosphatase SHP-2 regulates *induced* [ERK] activation in fibroblasts . Positive_regulation EPHB2 IL24 15563458 1375002 SHP-2 modulates *induced* Ca2+ flux and [ERK] activation via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL24 19646904 2125303 Interleukin-10 production by Th1 cells requires *induced* STAT4 transcription factor and [ERK] MAP kinase activation by high antigen dose . Positive_regulation EPHB2 IL24 20854249 2346675 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL24 23722307 2801764 The results showed that overexpression decreased the expression of CD44 , ICAM-1 , MMP-2/-9 , CyclinB , Twist , survivin , TGF-ß and p-Akt , transcriptional activity of NF-?B , and *increased* the expression of E-cadherin and [p-ERK] and transcriptional activity of AP-1 in HepG2 and BEL-7402 cells . Positive_regulation EPHB2 IL24 8830657 385506 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL24 9507015 491615 Requirements of focal adhesions and calcium fluxes for *induced* [ERK] kinase activation and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL25 12721296 1106474 The protein tyrosine phosphatase SHP-2 regulates induced [ERK] *activation* in fibroblasts . Positive_regulation EPHB2 IL25 15563458 1375003 SHP-2 modulates induced Ca2+ flux and [ERK] *activation* via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL25 19646904 2125304 Interleukin-10 production by Th1 cells requires induced STAT4 transcription factor and [ERK] MAP kinase *activation* by high antigen dose . Positive_regulation EPHB2 IL25 20854249 2346676 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL25 8830657 385507 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL25 9507015 491616 Requirements of focal adhesions and calcium fluxes for induced [ERK] kinase *activation* and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL26 12721296 1106479 The protein tyrosine phosphatase SHP-2 regulates *induced* [ERK] activation in fibroblasts . Positive_regulation EPHB2 IL26 15563458 1375008 SHP-2 modulates *induced* Ca2+ flux and [ERK] activation via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL26 19646904 2125309 Interleukin-10 production by Th1 cells requires *induced* STAT4 transcription factor and [ERK] MAP kinase activation by high antigen dose . Positive_regulation EPHB2 IL26 20854249 2346681 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL26 8830657 385512 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL26 9507015 491621 Requirements of focal adhesions and calcium fluxes for *induced* [ERK] kinase activation and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL27 12721296 1106480 The protein tyrosine phosphatase SHP-2 regulates induced [ERK] *activation* in fibroblasts . Positive_regulation EPHB2 IL27 15563458 1375009 SHP-2 modulates induced Ca2+ flux and [ERK] *activation* via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL27 19646904 2125310 Interleukin-10 production by Th1 cells requires induced STAT4 transcription factor and [ERK] MAP kinase *activation* by high antigen dose . Positive_regulation EPHB2 IL27 20854249 2346682 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL27 8830657 385513 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL27 9507015 491622 Requirements of focal adhesions and calcium fluxes for induced [ERK] kinase *activation* and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL3 10586114 571864 Despite the fact that did *induce* p38 and [ERK] kinase activity , it was not able to enhance IL-6 protein secretion , which coincided with the inability of IL-3 to induce NFkappaB ( nuclear factor kappaB ) activation and IkappaB ( inhibitory protein kappaB ) degradation . Positive_regulation EPHB2 IL3 10702314 672662 Granulocyte/macrophage colony stimulating factor , , and TPA , all of which induced macrophage proliferation , also *induced* [ERK] activity , which was maximal at 5 min poststimulation . Positive_regulation EPHB2 IL3 11909942 923835 Bone marrow derived Fps/Fes-null macrophages showed no defects in granulocyte-macrophage colony stimulating factor- , interleukin 6 (IL-6)- , or *induced* activation of signal transducer and activator of transcription 3 ( Stat3 ) and Stat5A or LPS induced degradation of I kappa B or activation of p38 , Jnk , [Erk] , or Akt . Positive_regulation EPHB2 IL3 12721296 1106493 The protein tyrosine phosphatase SHP-2 regulates *induced* [ERK] activation in fibroblasts . Positive_regulation EPHB2 IL3 12955078 1137680 Further biochemical analyses revealed that *induced* Jak/Stat , [Erk] , and PI3 kinase pathways in SHP-2 ( -/- ) cells were impaired and reintroduction of WT SHP-2 into mutant cells partially restored IL-3 signaling . Positive_regulation EPHB2 IL3 15465815 1342180 Spred-1 negatively regulates mediated [ERK/mitogen] activated protein (MAP) kinase *activation* in hematopoietic cells . Positive_regulation EPHB2 IL3 15465815 1342224 In contrast , DeltaC Spred augmented *induced* cell proliferation and [ERK] activation . Positive_regulation EPHB2 IL3 15465815 1342225 Augmentation of [ERK] activation and proliferation in *response* to was also observed in Spred-1-deficient bone marrow derived mast cells . Positive_regulation EPHB2 IL3 15465815 1342230 These data suggest that Spred-1 negatively regulates hematopoiesis by suppressing not only SCF induced but also induced [ERK] *activation* . Positive_regulation EPHB2 IL3 15563458 1375022 SHP-2 modulates *induced* Ca2+ flux and [ERK] activation via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL3 15601627 1356729 These results suggest that SDF-1 synergistically enhances *induced* [Erk] activation by up-regulating Raf-1 activity through the Rac effector Pak kinases to promote hematopoiesis . Positive_regulation EPHB2 IL3 15982852 1498004 The antioxidant N-acetyl-L-cysteine (NAC) inhibited *induced* tyrosine phosphorylation of Jak2 , IL-3 receptor betac subunit ( IL-3Rbetac ) , and STAT5 as well as activation-specific phosphorylation of Akt , MEK , and [ERK] , while treatment of cells with H2O2 activated these signaling events . Positive_regulation EPHB2 IL3 16115197 1448849 Forced expression of Cav-1 suppressed SCF- and induced proliferation and [ERK] *activation* . Positive_regulation EPHB2 IL3 16116188 1449013 Acute IL-3 priming up-regulates the stimulus induced Raf-1-Mek-Erk cascade independently of *induced* activation of [Erk] . Positive_regulation EPHB2 IL3 16116188 1449014 The kinetics , dose response , and pharmacologic characteristics of the IL-3 priming of stimulus induced Erk phosphorylation support the involvement of a yet unknown mechanism that is independent of *induced* [Erk] and PI3K activation . Positive_regulation EPHB2 IL3 16164983 1456403 Additionally , , which inhibits G-CSF induced differentiation of 32 Dc l3 cells , also *inhibited* the ability of G-CSF to stimulate prolonged [MEK/ERK] activation . Positive_regulation EPHB2 IL3 16371368 1526880 The E76K mutation in the N-terminal Src homology 2 domain increased interactions of mutant SHP-2 with Grb2 , Gab2 , and p85 , leading to hyperactivation of *induced* [Erk] and phosphatidylinositol 3-kinase (PI3K) pathways . Positive_regulation EPHB2 IL3 17374739 1760231 Gab2-deficient c-Kit ( + ) Lin ( - ) cells also demonstrate impaired activation of extracellular signal regulated kinase ( [ERK] ) and S6 in *response* to , which supports defects in activating the phosphatidylinositol-3 kinase (PI-3K) and mitogen associated protein kinase (MAPK) signaling cascades . Positive_regulation EPHB2 IL3 18955562 2034860 These effects are similar to that of IL-3 , but the signaling pathways engaged are distinct because IL-33 strongly activates NF-kappaB and shows a preference for p38 MAP-kinase , while acts through Jak/Stat and preferentially *activates* [ERK] . Positive_regulation EPHB2 IL3 19646904 2125323 Interleukin-10 production by Th1 cells requires *induced* STAT4 transcription factor and [ERK] MAP kinase activation by high antigen dose . Positive_regulation EPHB2 IL3 20854249 2346696 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL3 24841535 2951062 upregulated the expression of anti-apoptotic protein Bcl-xL and *activated* p38 , [ERK] and STAT5 signaling pathways in DCs . Positive_regulation EPHB2 IL3 8830657 385526 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL3 9507015 491635 Requirements of focal adhesions and calcium fluxes for *induced* [ERK] kinase activation and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL3 9593267 505704 In contrast , stimulation of the receptor in AML193 cells *resulted* in a transient [Erk] activation peaking at 5 min and returning to base levels after 15 min . Positive_regulation EPHB2 IL3 9885215 584445 cAMP dramatically increased [ERK] activity in the *presence* of CSF-1 or . Positive_regulation EPHB2 IL31 12721296 1106481 The protein tyrosine phosphatase SHP-2 regulates *induced* [ERK] activation in fibroblasts . Positive_regulation EPHB2 IL31 15563458 1375010 SHP-2 modulates *induced* Ca2+ flux and [ERK] activation via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL31 19646904 2125311 Interleukin-10 production by Th1 cells requires induced STAT4 transcription factor and [ERK] MAP kinase *activation* by high antigen dose . Positive_regulation EPHB2 IL31 20854249 2346683 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL31 8830657 385514 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL31 9507015 491623 Requirements of focal adhesions and calcium fluxes for *induced* [ERK] kinase activation and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL32 12721296 1106478 The protein tyrosine phosphatase SHP-2 regulates induced [ERK] *activation* in fibroblasts . Positive_regulation EPHB2 IL32 15563458 1375007 SHP-2 modulates induced Ca2+ flux and [ERK] *activation* via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL32 19646904 2125308 Interleukin-10 production by Th1 cells requires induced STAT4 transcription factor and [ERK] MAP kinase *activation* by high antigen dose . Positive_regulation EPHB2 IL32 20854249 2346680 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL32 8830657 385511 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL32 9507015 491620 Requirements of focal adhesions and calcium fluxes for induced [ERK] kinase *activation* and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL33 12721296 1106477 The protein tyrosine phosphatase SHP-2 regulates *induced* [ERK] activation in fibroblasts . Positive_regulation EPHB2 IL33 15563458 1375006 SHP-2 modulates *induced* Ca2+ flux and [ERK] activation via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL33 18603409 1935585 On the other hand , *induced* [ERK] activation was observed regardless of the presence of TRAF6 . Positive_regulation EPHB2 IL33 19646904 2125307 Interleukin-10 production by Th1 cells requires *induced* STAT4 transcription factor and [ERK] MAP kinase activation by high antigen dose . Positive_regulation EPHB2 IL33 20854249 2346679 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL33 20926795 2343328 *induced* activation of both [ERK] and p38 MAPK in endothelial cells but only ERK in epithelial cells . Positive_regulation EPHB2 IL33 23397250 2787080 *induces* CCL2 , TNF-a and nitric oxide release through phosphorylation of [ERK] in mouse astrocytes . Positive_regulation EPHB2 IL33 8830657 385510 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL33 9507015 491619 Requirements of focal adhesions and calcium fluxes for *induced* [ERK] kinase activation and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL34 12721296 1106482 The protein tyrosine phosphatase SHP-2 regulates induced [ERK] *activation* in fibroblasts . Positive_regulation EPHB2 IL34 15563458 1375011 SHP-2 modulates induced Ca2+ flux and [ERK] *activation* via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL34 19646904 2125312 Interleukin-10 production by Th1 cells requires induced STAT4 transcription factor and [ERK] MAP kinase *activation* by high antigen dose . Positive_regulation EPHB2 IL34 20854249 2346684 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL34 8830657 385515 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL34 9507015 491624 Requirements of focal adhesions and calcium fluxes for induced [ERK] kinase *activation* and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL37 12721296 1106476 The protein tyrosine phosphatase SHP-2 regulates induced [ERK] *activation* in fibroblasts . Positive_regulation EPHB2 IL37 15563458 1375005 SHP-2 modulates induced Ca2+ flux and [ERK] *activation* via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL37 19646904 2125306 Interleukin-10 production by Th1 cells requires induced STAT4 transcription factor and [ERK] MAP kinase *activation* by high antigen dose . Positive_regulation EPHB2 IL37 20854249 2346678 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL37 8830657 385509 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL37 9507015 491618 Requirements of focal adhesions and calcium fluxes for induced [ERK] kinase *activation* and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL3RA 20363735 2261076 In addition , expression of components of the interleukin-3 receptor , and the common beta chain , *activated* JAK2-V617F as well as STAT5 and [ERK] . Positive_regulation EPHB2 IL4 11709700 879829 In these cells , or IL-13 were shown to *activate* the Janus Kinases JAK1 and JAK2 , the transcription factor STAT6 , and the [ERK] and p38 mitogen activated protein kinases . Positive_regulation EPHB2 IL4 11956062 930905 Activation of IL-4Ralpha by IL-13 or *induced* signal transducer and activation of transcription-6 ( STAT6 ) , p42/ p44 [ERK] , p38 , and to a lesser extent , SAPK/JNK mitogen activated protein kinase phosphorylation . Positive_regulation EPHB2 IL4 12721296 1106494 The protein tyrosine phosphatase SHP-2 regulates induced [ERK] *activation* in fibroblasts . Positive_regulation EPHB2 IL4 15563458 1375023 SHP-2 modulates induced Ca2+ flux and [ERK] *activation* via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL4 16210650 1464505 [ERK] phosphorylation and chemokine production in response to LPA *require* dependent up-regulation of MEK-1 expression by a pathway involving PI3K . Positive_regulation EPHB2 IL4 16930576 1627243 In fact , *induced* specific activation of NF-kappaB , Akt , and [Erk] in Jurkat T cells and partially rescued these cells from dexamethasone induced apoptosis . Positive_regulation EPHB2 IL4 17433443 1736802 In cytokine producing Jurkat T cells , we have found that induces activation of Erk and Akt , and the IL-4 induced STAT6 activity is *suppressed* by inhibitors of [Erk] and PI3K . Positive_regulation EPHB2 IL4 18977218 1995151 Increased [ERK] phosphorylation was detected upon *stimulation* with Phenylephrine ( 2.6+/-0.1 times over basal ) , Endothelin-1 ( 1.8+/-0.2 ) , Dopamine ( 5.1+/-0.2 ) , TNF ( 9.8+/-0.7 ) or ( 3.1+/-0.3 ) . Positive_regulation EPHB2 IL4 19054919 1999830 Osthol did not suppress *induced* p38 , [ERK] or JNK expression . Positive_regulation EPHB2 IL4 19646904 2125324 Interleukin-10 production by Th1 cells requires induced STAT4 transcription factor and [ERK] MAP kinase *activation* by high antigen dose . Positive_regulation EPHB2 IL4 20854249 2346697 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL4 23043071 2720678 *activates* STAT6 and [ERK] and supports the differentiation of CD8 ( int ) PD-L1 ( hi ) CD44 ( hi ) EOMES ( + ) innate CD8 T cells . Positive_regulation EPHB2 IL4 23839108 2816111 Western blot analysis revealed that EGCG treatment prevented IL-1ß/IL-4 or *induced* [ERK] and JNK activation in HGFs . Positive_regulation EPHB2 IL4 8830657 385527 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL4 9507015 491636 Requirements of focal adhesions and calcium fluxes for induced [ERK] kinase *activation* and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL4R 11956062 930906 Activation of by IL-13 or IL-4 *induced* signal transducer and activation of transcription-6 ( STAT6 ) , p42/ p44 [ERK] , p38 , and to a lesser extent , SAPK/JNK mitogen activated protein kinase phosphorylation . Positive_regulation EPHB2 IL5 12721296 1106495 The protein tyrosine phosphatase SHP-2 regulates induced [ERK] *activation* in fibroblasts . Positive_regulation EPHB2 IL5 15563458 1375024 SHP-2 modulates *induced* Ca2+ flux and [ERK] activation via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL5 16671324 1558571 SPRED-1 modulates *dependent* [ERK] activation and eosinophilia . Positive_regulation EPHB2 IL5 19646904 2125325 Interleukin-10 production by Th1 cells requires *induced* STAT4 transcription factor and [ERK] MAP kinase activation by high antigen dose . Positive_regulation EPHB2 IL5 20854249 2346698 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL5 23684072 2819373 In contrast , an ROS inhibitor prevented the *induced* enhancement of [ERK] phosphorylation and cell death . Positive_regulation EPHB2 IL5 23684072 2819375 In activated eosinophils ligation of Siglec-8 leads to ROS dependent enhancement of *induced* [ERK] phosphorylation , which results in a novel mode of biochemically regulated eosinophil cell death . Positive_regulation EPHB2 IL5 23770289 2812241 The p21WAF1-specific small interfering RNA inhibited *induced* cell migration , [ERK] activity , MMP-9 expression , and activation of NF-?B and AP-1 in bladder cancer cells . Positive_regulation EPHB2 IL5 8830657 385528 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL5 9507015 491637 Requirements of focal adhesions and calcium fluxes for *induced* [ERK] kinase activation and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL6 11083274 750486 Tumor necrosis factor alpha , interleukin-1 (IL-1) , and were the major *inducers* of [ERK] , JNK , and p38 MAPK activation in cultured human synovial cells . Positive_regulation EPHB2 IL6 11225245 763958 Both the transcription factors-STAT3 , NF-IL-6 and protein kinases-Jak1 , [ERK] were *activated* by in Sko-007 cells . Positive_regulation EPHB2 IL6 11314001 806253 In Hep3B cells , the JAK/STAT3 , [ERK] , and PI 3-K/Akt pathways were *activated* by stimulation . Positive_regulation EPHB2 IL6 11556393 861069 Interestingly , no requirement of the Y759 mediated signals , including SHP-2 mediated Erk/MAP kinase pathway , coincided with the failure of SHP-2 , Gab1/Gab2 , and [Erk/MAP] kinase *activation* by in MH60 cells . Positive_regulation EPHB2 IL6 12721296 1106496 The protein tyrosine phosphatase SHP-2 regulates *induced* [ERK] activation in fibroblasts . Positive_regulation EPHB2 IL6 12813136 1103122 FTIs were also able to abrogate the IL-6 proliferative response of WT ras expressing MM cells , and this was associated with inhibition of *induced* activation of [ERK] , AKT , and p70 . Positive_regulation EPHB2 IL6 15563458 1375025 SHP-2 modulates induced Ca2+ flux and [ERK] *activation* via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL6 15780071 1385158 Using in vitro cell cultures , we demonstrated that *stimulated* STAT3 and [extracellular regulated kinase (ERK)] activity in both HCC cells and isolated hepatocytes . Positive_regulation EPHB2 IL6 15780071 1385159 However , while STAT3 activation profiles were similar , *stimulated* [ERK] activity in a biphasic manner in HCC cells and a monophasic , sustained ERK activation in hepatocytes . Positive_regulation EPHB2 IL6 16598747 1604392 In addition , *activated* [ERK] in PSCs . Positive_regulation EPHB2 IL6 18214991 1895514 markedly *increases* STAT-3 and [ERK] phosphorylation after 20 min of treatment , whereas these signal transducers are weakly stimulated by CNTF across a range of doses . Positive_regulation EPHB2 IL6 19211730 2054254 Urocortin *induces* release from rat cardiomyocytes through p38 MAP kinase , [ERK] and NF-kappaB activation . Positive_regulation EPHB2 IL6 19267906 2051229 Whereas *activated* STAT-3 and [ERK] phosphorylation , CNTF did not activate these pathways , nor did CNTF increase p38 MAP kinase phosphorylation . Positive_regulation EPHB2 IL6 19383353 2007984 Upon treatment with curcumin , *induced* STAT3 and [Erk] phosphorylation was dramatically reduced in the co-cultured cells . Positive_regulation EPHB2 IL6 19383353 2007986 In a combination treatment with curcumin and bortezomib , *induced* STAT3 and [Erk] phosphorylation was effectively inhibited . Positive_regulation EPHB2 IL6 19646904 2125326 Interleukin-10 production by Th1 cells requires induced STAT4 transcription factor and [ERK] MAP kinase *activation* by high antigen dose . Positive_regulation EPHB2 IL6 20854249 2346699 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL6 21123455 2377636 [ERK] *activation* by the complex increased endothelial integrity via Src kinase activation and Y685 phosphorylation of VE-cadherin . Positive_regulation EPHB2 IL6 21263382 2414443 *induced* phosphorylation of [ERK] , JNK , and PI3K , and inhibition of each suppressed IL-6 induced VEGF production . Positive_regulation EPHB2 IL6 22313262 2600252 Inhibition of STAT3 in fibroblasts potentiated *induced* [ERK] phosphorylation and vice versa . Positive_regulation EPHB2 IL6 22648519 2686843 Further analysis demonstrated that ISL not only downregulated IL-6 expression but also significantly decreased levels of phosphorylated ERK and STAT3 and could inhibit phosphorylation levels of [ERK] and STAT3 *induced* by recombinant human , which are critical signaling proteins in IL-6 signaling regulation networks . Positive_regulation EPHB2 IL6 23541910 2788867 Further examination indicated that , although IL6 was able to activate Erk in sparsely growing cells , could not induce an *increase* in [Erk] activity levels in densely growing cultures . Positive_regulation EPHB2 IL6 23541910 2788869 Most importantly , cadherin-11 knock-down did allow [Erk] *activation* by at high densities , indicating that it is indeed cadherin engagement that prevents Erk activation by IL6 . Positive_regulation EPHB2 IL6 23619565 2804768 Further studies revealed that PL suppressed the production of tumor necrosis factor-a (TNF-a) or and *activation* of nuclear factor-?B ( NF-?B ) or [extracellular regulated kinases (ERK)] 1/2 by LPS . Positive_regulation EPHB2 IL6 23677697 2805655 also *induces* a temporary and significant activation of [ERK] , but not sustained activation , and change sustained activation in MPP ( + ) -treated group into temporary activation . Positive_regulation EPHB2 IL6 23734186 2796953 This increased secretion of TNF-alpha and and *activation* of NF-kB , [ERK] , and JNK was significantly inhibited by the addition of either mannan or mannose . Positive_regulation EPHB2 IL6 24262867 2898244 Further studies revealed that PT suppressed the production of tumor necrosis factor-a (TNF-a) or and *activation* of nuclear factor-?B ( NF-?B ) or [extracellular regulated kinases (ERK)] 1/2 by LPS . Positive_regulation EPHB2 IL6 8662831 367395 Importantly , does not *enhance* [ERK] phosphorylation in the presence of either NGF or EGF . Positive_regulation EPHB2 IL6 8830657 385529 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL6 8941662 399293 However , [ERK] was also *activated* by PDGF , IGF-1 , and . Positive_regulation EPHB2 IL6 9507015 491638 Requirements of focal adhesions and calcium fluxes for *induced* [ERK] kinase activation and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL7 12721296 1106497 The protein tyrosine phosphatase SHP-2 regulates induced [ERK] *activation* in fibroblasts . Positive_regulation EPHB2 IL7 15563458 1375026 SHP-2 modulates *induced* Ca2+ flux and [ERK] activation via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL7 16019476 1432069 *induces* the activation of Jak/STAT , [MEK/Erk] and PI3K/Akt signaling pathways in T-ALL cells . Positive_regulation EPHB2 IL7 19646904 2125327 Interleukin-10 production by Th1 cells requires *induced* STAT4 transcription factor and [ERK] MAP kinase activation by high antigen dose . Positive_regulation EPHB2 IL7 20854249 2346700 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL7 8830657 385530 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL7 8921960 396881 Further studies confirmed that was unable to *induce* the phosphorylation of either the p44MAP/Erk or [p42MAP/Erk] or activation of the kinases . Positive_regulation EPHB2 IL7 9507015 491639 Requirements of focal adhesions and calcium fluxes for induced [ERK] kinase *activation* and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL8 11413312 828922 Further , the kinetics of [Erk] activation and *induction* suggest that an early viral event , such as receptor binding , may be responsible for the observed inflammatory response . Positive_regulation EPHB2 IL8 12721296 1106498 The protein tyrosine phosphatase SHP-2 regulates *induced* [ERK] activation in fibroblasts . Positive_regulation EPHB2 IL8 15047831 1225124 Adenovirus type 7 induces in a lung slice model and *requires* activation of [Erk] . Positive_regulation EPHB2 IL8 15563458 1375027 SHP-2 modulates induced Ca2+ flux and [ERK] *activation* via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL8 15724247 1376869 SAA dependent gene expression *required* activation of the MAPK [ERK] , p38 and JNK in HT-29 cells . Positive_regulation EPHB2 IL8 16846747 1592270 We previously established that stimulation by IGF-I of expression in leukocytes *required* activation of [extracellular regulated kinase (ERK)] and basal activity of c-Jun N-terminal kinase (JNK) . Positive_regulation EPHB2 IL8 16990258 1647133 Although both mutant and wild-type receptors could mediate Akt and [Erk] activation in *response* to , the level of activation of these two kinases was much lower in the cell line expressing the mutant receptors . Positive_regulation EPHB2 IL8 17517062 1791886 At acidic pH H. pylori *induced* augmentation of production involved markedly upregulated the NF-kappaB pathways and the [ERK] -- > c-Fos -- > AP-1 pathways . Positive_regulation EPHB2 IL8 19646904 2125328 Interleukin-10 production by Th1 cells requires induced STAT4 transcription factor and [ERK] MAP kinase *activation* by high antigen dose . Positive_regulation EPHB2 IL8 19672789 2162811 The interaction of alphaPix with CagA activates PAK1 , [ERK] and NF-kappaB , which *induces* expression in H. pylori infected gastric epithelial cells . Positive_regulation EPHB2 IL8 19801670 2159618 Phosphoglucose isomerase/autocrine motility factor promotes melanoma cell migration through [ERK] activation *dependent* on autocrine production of . Positive_regulation EPHB2 IL8 20854249 2346701 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL8 22411631 2630626 N. fowleri induced expression *requires* activation of [ERK] in human astroglial cells . Positive_regulation EPHB2 IL8 8830657 385531 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL8 9507015 491640 Requirements of focal adhesions and calcium fluxes for *induced* [ERK] kinase activation and c-fos expression in fibroblasts . Positive_regulation EPHB2 IL8 9843397 553046 Both and GROalpha *activate* [ERK] and MEK through R2 , whereas MIP-1alpha , a beta chemokine , does not activate these kinases through either of these receptors . Positive_regulation EPHB2 IL9 12721296 1106499 The protein tyrosine phosphatase SHP-2 regulates induced [ERK] *activation* in fibroblasts . Positive_regulation EPHB2 IL9 15563458 1375028 SHP-2 modulates *induced* Ca2+ flux and [ERK] activation via phosphorylation of phospholipase Cgamma1 . Positive_regulation EPHB2 IL9 19646904 2125329 Interleukin-10 production by Th1 cells requires *induced* STAT4 transcription factor and [ERK] MAP kinase activation by high antigen dose . Positive_regulation EPHB2 IL9 20854249 2346702 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , ( IL-1ß *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not [ERK] ) MAP kinases . Positive_regulation EPHB2 IL9 8830657 385532 1 *activates* jun N-terminal kinases JNK1 and JNK2 but not [extracellular regulated MAP kinase (ERK)] in human glomerular mesangial cells . Positive_regulation EPHB2 IL9 9507015 491641 Requirements of focal adhesions and calcium fluxes for induced [ERK] kinase *activation* and c-fos expression in fibroblasts . Positive_regulation EPHB2 INHBA 21784102 2467481 This finding that *induces* [ERK] and CREB phosphorylation suggests that ERK and CREB act as intermediates in APRIL expression . Positive_regulation EPHB2 INS 10373477 622572 To examine the relationship between the Grb2-SOS complex and Ras activation , we observed that stimulation *results* in a rapid but transient activation of Ras and the extracellular-signal regulated kinase ( [ERK] ) followed by dissociation of the Grb2-SOS complex . Positive_regulation EPHB2 INS 10400063 628089 Thus , is *involved* in [ERK] regulation in fetal astrocytes . Positive_regulation EPHB2 INS 10516133 652256 We conclude that 1 ) and contraction *activate* [ERK] signaling in skeletal muscle ; Positive_regulation EPHB2 INS 10669726 665926 In contrast , ( 10 nM ) *caused* sustained IRS-1 phosphorylation and [ERK] activation . Positive_regulation EPHB2 INS 11078444 749342 Both sorbitol and strongly *stimulated* [extracellular regulated kinase (ERK)] 1 and 2 phosphorylation ( 8- and 18-fold , respectively ) . Positive_regulation EPHB2 INS 11113183 768268 While and exercise significantly *increased* [ERK] phosphorylation in skeletal muscle from both WT and KO mice , the increases were twofold greater in the KO animals . Positive_regulation EPHB2 INS 11113183 768273 The enhanced *stimulated* increases in [ERK] and glycogen synthase activities in KO mice were not associated with higher insulin receptor or with IRS1 tyrosine phosphorylation or with IRS1 binding to phosphatidylinositol 3-kinase . Positive_regulation EPHB2 INS 11594774 870072 The protein kinase C ( PKC ) inhibitor bisindolylmaleimide abolished PDGF but not IGF-I or *induced* [ERK] activation . Positive_regulation EPHB2 INS 11594774 870074 [ERK] *activation* by , IGF-I , or PDGF was unaffected by the phosphatidylinositol 3-kinase inhibitor wortmannin but was abolished by the MEK inhibitor PD98059 . Positive_regulation EPHB2 INS 12052829 968794 Overexpression of a PTP-PEST binding-defective mutant of p52 ( Shc ) ( S29A ) enhanced *induced* [ERK] activation in insulin receptor overexpressing HIRc-B cells . Positive_regulation EPHB2 INS 12374468 996584 To assess insulin receptor (IR) , Shc , STAT-1 , [ERK] , and Akt phosphorylation in *response* to in lacrimal gland and salivary gland , tissues from female and male rats ( n = 5-8/group ) were submitted to immunoprecipitation and immunoblotting or Western blotting protocol , and phosphorylation level was determined by densitometry . Positive_regulation EPHB2 INS 12458213 1037593 *induced* [ERK] activation was diminished in MEKK1-deficient cells , but phosphatidylinositol 3-kinase/Akt activation was not . Positive_regulation EPHB2 INS 12684506 1093262 Furthermore , we examined the effect of L-PGDS incubation on *stimulated* Akt , glycogen synthase kinase-3beta ( GSK-3beta ) , and [ERK] phosphorylation . Positive_regulation EPHB2 INS 12684506 1093267 *stimulated* [ERK] phosphorylation was unaffected by L-PGDS pretreatment in both cell lines . Positive_regulation EPHB2 INS 12887130 1116904 *induced* [ERK] phosphorylation in a dose dependent manner in VSMC . Positive_regulation EPHB2 INS 12894221 1117934 We show that CrkII overexpression is capable of enhancing *stimulated* [ERK] activity , whereas CrkIII is not , thus partially characterizing a novel member of the Crk family and elucidating important effects mediated by the c-terminal SH3 domain . Positive_regulation EPHB2 INS 15228086 1268870 In contrast , activation of p38 MAPK was impaired in insulin resistant cells , where as [ERK] and JNK were *activated* by . Positive_regulation EPHB2 INS 15337530 1291362 Drosophila PI3 kinase and Akt involved in *stimulated* proliferation and [ERK] pathway activation in Schneider cells . Positive_regulation EPHB2 INS 15536206 1367499 However , *stimulated* activation of [ERK] , a signaling pathway parallel to Akt/PKB , was not affected by burn injury . Positive_regulation EPHB2 INS 15550510 1367869 The metabolic effects produced by IRS-1AS were accompanied by a significant reduction in insulin induced [ Ser ( 473 ) ] Akt phosphorylation in liver ( 85 % , P < 0.05 ) , skeletal muscle ( 40 % , P < 0.05 ) , and adipose tissue ( 85 % , P < 0.05 ) and a significant reduction in *induced* tyrosine phosphorylation of [ERK] in liver ( 20 % , P < 0.05 ) and skeletal muscle ( 30 % , P < 0.05 ) . Positive_regulation EPHB2 INS 15550510 1367873 However , *induced* tyrosine phosphorylation of [ERK] was significantly increased ( 60 % , P < 0.05 ) in adipose tissue of IRS-1AS treated rats . Positive_regulation EPHB2 INS 15764603 1403598 *induced* [ERK] phosphorylation was much more sensitive to IRS-2 than IRS-1 ablation , whereas p38MAPK phosphorylation was reduced by 43 or 62 % in myotubes treated with siIRS-1 or siIRS-2 , respectively . Positive_regulation EPHB2 INS 15781236 1385454 Direct interaction between ERK and caveolin-2 was confirmed by immunoprecipitation and phosphorylated [ERK] increased the specific interaction in *response* to . Positive_regulation EPHB2 INS 15821749 1403860 Conversely , [Erk] *activation* by was suppressed in LGKO liver , leading to defective IRS-1 Ser612 phosphorylation . Positive_regulation EPHB2 INS 16210359 1501026 DHT exposure resulted in reduced *stimulated* [ERK] phosphorylation . Positive_regulation EPHB2 INS 16246039 1471360 Oxidized low-density lipoprotein inhibits *dependent* phosphorylation of the signalling kinases [ERK] ( extracellular-signal regulated kinase ) and PKB/Akt . Positive_regulation EPHB2 INS 16620782 1551324 Consistent with these findings , apoB-deficient hepatocytes responded to insulin to a similar extent as the control cells as determined by measuring *induced* phosphorylation of IRS and [ERK] . Positive_regulation EPHB2 INS 16805793 1579616 Enhancement of *induced* PI3K/Akt/GSK-3beta and [ERK] signaling by neuronal nicotinic receptor/PKC-alpha/ERK pathway : up-regulation of IRS-1/-2 mRNA and protein in adrenal chromaffin cells . Positive_regulation EPHB2 INS 16844778 1592166 However , Hsp90 inhibition has recently been reported to activate Akt and [Erk] and potentiate Akt activation *induced* by insulin-like growth factor 1 and , raising the concern that clinical use of Hsp90 inhibitors might promote tumor progression under certain circumstances . Positive_regulation EPHB2 INS 16988072 1617882 However , INS did not block the GH-induced activation of STAT5 , and GH did not block the *induction* of [ERK] activity or of increased glucose uptake . Positive_regulation EPHB2 INS 17149366 1661617 Inhibition of EGFR activation by AG1478 or the MMP inhibitor , GM6001 , reduced phosphorylation of *induced* [ERK] in the presence of insulin and delayed wound closure . Positive_regulation EPHB2 INS 17210122 1688989 In addition , we demonstrated that PMA , , and PDGF *increased* both the stability of endogenous expressed SOCS6 and [Erk] activation in MDA-MB231 cells . Positive_regulation EPHB2 INS 17659595 1805157 Differential , age dependent [MEK-ERK] and PI3K-Akt *activation* by acting as a survival factor during embryonic retinal development . Positive_regulation EPHB2 INS 18701453 1979677 High glucose and high *augmented* activation of Akt , [Erk] , and p70S6 kinase . Positive_regulation EPHB2 INS 18952605 2001054 Overexpression of the mutant KSR1 in HIRcB cells inhibited *dependent* MEK and [ERK] phosphorylation . Positive_regulation EPHB2 INS 19357636 2058171 In HEK293 cells , is a poor activator of the Ras/ERK ( extracellular signal regulated kinase ) cascade , yet it *enhances* [ERK] activation by low EGF doses . Positive_regulation EPHB2 INS 19394055 2089398 *induced* phosphorylation of Akt and [Erk] in adipose tissues , skeletal muscles , and liver was greatly attenuated in HFHS rats as compared with chow fed controls . Positive_regulation EPHB2 INS 19502797 2098141 Concomitantly , stimulation *induced* Raf-1 and [ERK] activation , followed by thymidine uptake . Positive_regulation EPHB2 INS 19502797 2098145 Inhibition of CaMKII abrogated the *induced* Raf-1 and [ERK] activation , resulting also in the inhibition of thymidine incorporation . Positive_regulation EPHB2 INS 19778377 2141115 Down-regulation of caveolin-2 by caveolin-2 siRNA arrested the *induced* nuclear localization of [ERK] with no change in the insulin stimulated ERK activation . Positive_regulation EPHB2 INS 20004975 2199836 We found that alone stimulates tyrosine phosphorylation of tyrosine kinases Lyn , Syk , Fyn , the adapter protein Gab2 ( Grb2 associated binding protein 2 ) , Akt and *activates* [ERK] , JNK and p38 kinase . Positive_regulation EPHB2 INS 20056832 2201035 *stimulated* [ERK] phosphorylation was abrogated by calcium chelation , calcineurin and calmodulin dependent protein kinase II inhibitors , and Ned-19 , a nicotinic acid adenine dinucleotide phosphate receptor ( NAADPR ) antagonist . Positive_regulation EPHB2 INS 20455999 2418827 However , *stimulated* activation of [ERK] was induced by exogenous addition of cav-2 . Positive_regulation EPHB2 INS 20841350 2353029 In contrast , *induced* [ERK] activation was dramatically attenuated , yet there was no effect on the putative ERK site on IRS1 ( Ser ( 612 ) ) or on S6 kinase 1 activity . Positive_regulation EPHB2 INS 20924651 2364688 Taken together , our data indicate that PI3K-C2a may be a crucial factor in the stimulation of [ERK] activity in *response* to serum or , whereas it is less important for the stimulation of PKB/Akt activity in response to insulin . Positive_regulation EPHB2 INS 21353259 2453151 Consistent with this , basal and *stimulated* [Erk] and Akt phosphorylations were comparable in adipose tissue of Shp2-deficient and control mice . Positive_regulation EPHB2 INS 21429300 2406305 *stimulated* [ERK] activity was completely suppressed by cAMP elevating agents like as pertussis toxin (Ptx) and cholera toxin ( Ctx ) after 4 h treatment . Positive_regulation EPHB2 INS 21465524 2412943 Knock-down of PTEN potentiated the increase in *mediated* phosphorylation of [Akt/ERK] . Positive_regulation EPHB2 INS 21646299 2446272 *dependent* phosphatidylinositol 3-kinase/Akt and [ERK] signaling pathways inhibit TLR3 mediated human bronchial epithelial cell apoptosis . Positive_regulation EPHB2 INS 21854769 2477555 *induced* [ERK] and Akt activation , and thymidine incorporation were inhibited by siRNA for the IGF-1 receptor . Positive_regulation EPHB2 INS 22019459 2533689 GGPP treatment of MC3T3-E1 pre-osteoblasts and primary calvarial osteoblasts led to enhanced *induced* [Erk] signaling which has been previously demonstrated to inhibit insulin receptor substrate (IRS)-1 activity . Positive_regulation EPHB2 INS 22094332 2548281 In separate experiments , we evaluated the effect of 200 µM palmitate , in the presence and absence of 8 µM pioglitazone , on *stimulated* ( 100 nM for 20 min ) Akt and [Erk] phosphorylation . Positive_regulation EPHB2 INS 22094332 2548288 With addition of pioglitazone , the phosphorylation of Akt by insulin remained unchanged , whereas *stimulated* [Erk] phosphorylation was reduced by pioglitazone . Positive_regulation EPHB2 INS 22137902 2562895 treatment *induced* a transient increase in [ERK] phosphorylation in 3T3-L1 preadipocytes , and maximal induction was observed at 5 min and then declined . Positive_regulation EPHB2 INS 22194983 2518672 *induced* the activation of extracellular signal regulated kinase ( [ERK] ) 1/2 , mitogen activated protein kinase (MAPK) and RAC-alpha serine/threonine-protein kinase ( Akt ) . Positive_regulation EPHB2 INS 23531619 2787965 Elevated SHP-1 expression induced by high glucose levels was directly associated with insulin receptor-ß in vitro and in vivo to prevent *stimulated* Akt and [ERK] phosphorylation . Positive_regulation EPHB2 INS 24008344 2856553 Under control conditions , *stimulated* Akt and [Erk] activation and fatty acid uptake in WAT were not significantly affected by the ovarian cycle . Positive_regulation EPHB2 INS 24575365 2919978 Impairment of *stimulated* glucose transport and [ERK] activation by adipocyte-specific knockout of PKC-? produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis . Positive_regulation EPHB2 INS 24575365 2919981 We conclude that : PKC-? is required for *stimulated* glucose transport and [ERK] signaling in mouse adipocytes ; Positive_regulation EPHB2 INS 24646332 2925814 Leucine is also shown to increase the magnitude of *mediated* [extracellularly regulated kinase (ERK)] phosphorylation ; Positive_regulation EPHB2 INS 8552085 347152 Expression of a dominant interfering MEK mutant , in which lysine 97 was replaced with arginine ( MEK/K97R ) , resulted in an inhibition of *stimulated* SOS and [ERK] phosphorylation , whereas expression of a constitutively active MEK mutant , in which serines 218 and 222 were replaced with glutamic acid ( MEK/EE ) , induced basal phosphorylation of both SOS and ERK . Positive_regulation EPHB2 INS 9478933 487014 *induced* [ERK] activation was completely abolished , while ERK activity upon platelet derived growth factor and epidermal growth factor stimulation was significantly reduced and shortened in mutant cells . Positive_regulation EPHB2 INS 9753291 533894 significantly *increased* [ERK] phosphorylation and the activity of its downstream substrate , the p90 ribosomal S6 kinase 2 (RSK2) , by 1.4-fold , but it had no effect on JNK activity . Positive_regulation EPHB2 INSIG1 15731359 1402998 We report that : 1 ) insulin induced transcription of ATF-3 , Pip92 , and *required* [MEK-ERK] activation ; Positive_regulation EPHB2 INSR 19906834 2203536 Both visfatin and nicotinamide mononucleotide *induced* activation of both insulin receptor and extracellular signal regulated kinase ( [ERK] ) 1/2 , with visfatin induced activation being inhibited by FK866 . Positive_regulation EPHB2 INSR 24071517 2888408 Tetramethylpyrazine reduces glucose and insulin induced activation of hepatic stellate cells by inhibiting *mediated* PI3K/AKT and [ERK] pathways . Positive_regulation EPHB2 INTS6 17895999 1802821 We find that is *required* for normal expression of MEK1 protein in human cells , and for [Erk] signaling in zebrafish embryos . Positive_regulation EPHB2 IQGAP1 16135787 1450341 We previously documented that binds extracellular signal regulated kinase ( ERK ) 2 and *regulates* growth factor stimulated [ERK] activity . Positive_regulation EPHB2 IQGAP1 16135787 1450366 In addition , both knockdown and overexpression of *reduced* EGF stimulated activation of MEK and [ERK] . Positive_regulation EPHB2 IQGAP1 17563371 1763003 We previously documented that binds ERK and MAPK kinase ( MEK ) and *regulates* EGF stimulated MEK and [ERK] activity . Positive_regulation EPHB2 IQGAP1 18567582 1946391 binds to and *regulates* the activities of [ERK] , MEK , and B-Raf . Positive_regulation EPHB2 IQSEC1 22701712 2615840 is *required* for epidermal growth factor induced [ERK/Rac1] signaling and cell migration in human hepatoma HepG2 cells . Positive_regulation EPHB2 IRAK1 10823834 714946 Fibroblasts electroinjected with a mouse monoclonal anti-IRAK antibody to block the recruitment of IRAK into FACs failed to activate ERK after IL-1 treatment , indicating that FAC associated is *required* for the activation of [ERK] . Positive_regulation EPHB2 IRAK2 10823834 714947 Fibroblasts electroinjected with a mouse monoclonal anti-IRAK antibody to block the recruitment of IRAK into FACs failed to activate ERK after IL-1 treatment , indicating that FAC associated is *required* for the activation of [ERK] . Positive_regulation EPHB2 IRAK3 10823834 714944 Fibroblasts electroinjected with a mouse monoclonal anti-IRAK antibody to block the recruitment of IRAK into FACs failed to activate ERK after IL-1 treatment , indicating that FAC associated is *required* for the activation of [ERK] . Positive_regulation EPHB2 IRAK4 10823834 714945 Fibroblasts electroinjected with a mouse monoclonal anti-IRAK antibody to block the recruitment of IRAK into FACs failed to activate ERK after IL-1 treatment , indicating that FAC associated is *required* for the activation of [ERK] . Positive_regulation EPHB2 IRS1 17553792 1785804 In DeltaIGF-1R osteoblasts , insulin signaling was markedly increased as evidenced by increased phosphorylation of and enhanced [ERK/Akt] *activation* . Positive_regulation EPHB2 IRS1 19164446 2048418 We previously reported that and Janus kinase 2 associate independently of tyrosine phosphorylation via IRS-1 's N terminus and that IRS-1 reconstitution greatly *enhances* GH-induced [ERK] , but not STAT5 , activation . Positive_regulation EPHB2 IRS1 19164446 2048420 These data suggest that LR-enriched *contributes* substantially to GH-induced [ERK] activation in LR in 3T3-F442A fibroblasts . Positive_regulation EPHB2 IRS1 23607966 2795234 mTORC1 inhibition induces pain via *dependent* feedback activation of [ERK] . Positive_regulation EPHB2 IRS1 23639626 2800415 By `` working upwards '' from mTOR , we observed that TCDD *inhibited* endogenous and IGF-I induced AKT and [ERK] activation by interfering with tyrosine phosphorylation of . Positive_regulation EPHB2 IRS2 15764603 1403604 We conclude that insulin stimulated Akt1 phosphorylation , actin remodeling , GLUT4 translocation , and glucose uptake are regulated mainly by IRS-1 , whereas *contributes* selectively to [ERK] signaling , and Akt2 and p38MAPK lie downstream of both IRS in muscle cells . Positive_regulation EPHB2 IRS2 17553792 1785805 In DeltaIGF-1R osteoblasts , insulin signaling was markedly increased as evidenced by increased phosphorylation of and enhanced [ERK/Akt] *activation* . Positive_regulation EPHB2 IRS2 20145041 2214689 Sustained JNK activity enhanced mediated [ERK] *activation* , which in turn increased c-Fos expression and activator protein activity . Positive_regulation EPHB2 ITGA4 9092580 422123 Inhibition of tyrosine kinase activity with genistein ( 10 microg/ml ) as well as selective MAP kinase inhibition with the MEK-1 inhibitor PD98059 abolished the *dependent* [ERK] tyrosine phosphorylation , inhibited NF kappaB nuclear binding , and abrogated tissue factor expression induced by both VLA-4 cross linking and adhesion to fibronectin in THP-1 cells and human peripheral blood monocytes . Positive_regulation EPHB2 ITGA5 12657612 1073271 Fibronectin fragments promote human retinal endothelial cell adhesion and proliferation and [ERK] *activation* through and PI 3-kinase . Positive_regulation EPHB2 ITGA5 17849175 1842822 In cultured ECs , Fg binding to intercellular adhesion molecule-1 and to , *caused* phosphorylation of [ERK] . Positive_regulation EPHB2 ITGA6 12802077 1101284 The [ERK] activation was *mediated* by and not by alpha3beta1 or dystroglycan . Positive_regulation EPHB2 ITGA6 12802077 1101286 Instead , we found that dystroglycan binding domains of both laminin-1 and -10/11 suppressed mediated [ERK] *activation* . Positive_regulation EPHB2 ITGA6 16870608 1613610 Ligation of , a major Ln-5 receptor aberrantly expressed by ADPKD cells , *induces* beta ( 4 ) integrin phosphorylation , [ERK] activation , cell proliferation , and cyst formation . Positive_regulation EPHB2 ITGAM 11099490 780073 Neither ONOO -- induced up-regulation of expression nor [Erk] *activation* was affected by SB 203580 , a selective inhibitor of p38 MAPK . Positive_regulation EPHB2 ITGAV 18310446 1879047 To establish whether transient [ERK] *activation* via the cell surface receptor mediated these effects , MG-63 cells were pretreated for 30 min with the specific MAPK kinase inhibitor , U0126 ( 1 microM ) , or an anti-integrin alpha(V)beta(3) blocking antibody . Positive_regulation EPHB2 ITGAV 19581046 2194853 Taken together , the data suggest that VEGF is critical to the invasive process in human gastric cancer and that this occurs via up-regulation of expression and *activation* of [ERK] . Positive_regulation EPHB2 ITGB1 12657612 1073272 Fibronectin fragments promote human retinal endothelial cell adhesion and proliferation and [ERK] *activation* through and PI 3-kinase . Positive_regulation EPHB2 ITGB1 12802077 1101285 The [ERK] activation was *mediated* by and not by alpha3beta1 or dystroglycan . Positive_regulation EPHB2 ITGB1 12802077 1101287 Instead , we found that dystroglycan binding domains of both laminin-1 and -10/11 suppressed mediated [ERK] *activation* . Positive_regulation EPHB2 ITGB1 15597106 1369026 However , is not *required* for cell growth or activation of FAK and [ERK] signalling in vitro or in vivo . Positive_regulation EPHB2 ITGB1 17849175 1842823 In cultured ECs , Fg binding to intercellular adhesion molecule-1 and to , *caused* phosphorylation of [ERK] . Positive_regulation EPHB2 ITGB1 9092580 422124 Inhibition of tyrosine kinase activity with genistein ( 10 microg/ml ) as well as selective MAP kinase inhibition with the MEK-1 inhibitor PD98059 abolished the *dependent* [ERK] tyrosine phosphorylation , inhibited NF kappaB nuclear binding , and abrogated tissue factor expression induced by both VLA-4 cross linking and adhesion to fibronectin in THP-1 cells and human peripheral blood monocytes . Positive_regulation EPHB2 ITGB2 11099490 780074 Neither ONOO -- induced up-regulation of expression nor [Erk] *activation* was affected by SB 203580 , a selective inhibitor of p38 MAPK . Positive_regulation EPHB2 ITGB3 18310446 1879048 To establish whether transient [ERK] *activation* via the cell surface receptor mediated these effects , MG-63 cells were pretreated for 30 min with the specific MAPK kinase inhibitor , U0126 ( 1 microM ) , or an anti-integrin alpha(V)beta(3) blocking antibody . Positive_regulation EPHB2 ITGB4 16870608 1613611 Ligation of , a major Ln-5 receptor aberrantly expressed by ADPKD cells , *induces* beta ( 4 ) integrin phosphorylation , [ERK] activation , cell proliferation , and cyst formation . Positive_regulation EPHB2 ITGB6 19581046 2194854 Taken together , the data suggest that VEGF is critical to the invasive process in human gastric cancer and that this occurs via up-regulation of expression and *activation* of [ERK] . Positive_regulation EPHB2 ITIH4 22028271 2539987 Here , we show that NHERF1 can associate with CCR5 , and promote activation of the *induced* [MAPK/ERK] , focal adhesion kinase and RhoA ( Ras homolog gene family member A ) signaling pathways . Positive_regulation EPHB2 ITIH4 9403476 469598 Human immunodeficiency virus type 1 and its coat protein induce apoptosis and *activate* JNK and [ERK] mitogen activated protein kinases in human neurons . Positive_regulation EPHB2 ITIH4 9403476 469599 *activated* c-Jun N-terminal kinase (JNK) and p42 [extracellular regulated kinase (ERK)] in primary CNS cells , with an early peak of activation at 2 to 5 minutes that was not present when pure microglial or astrocyte cultures were tested , followed by a late and sustained activation ( 10 and 60 minutes ) in primary and enriched glial cell cultures as well as in transformed microglial cells . Positive_regulation EPHB2 JAK1 12955078 1137681 Further biochemical analyses revealed that IL-3 *induced* , [Erk] , and PI3 kinase pathways in SHP-2 ( -/- ) cells were impaired and reintroduction of WT SHP-2 into mutant cells partially restored IL-3 signaling . Positive_regulation EPHB2 JAK1 17255201 1725198 Prolactin *induced* phosphorylation of JAK2 and [ERK] , whereas IFN-gamma induced phosphorylation of , JAK2 , and p38 MAPK . Positive_regulation EPHB2 JAK1 17363567 1713059 Leptin induced phosphorylation of [ERK] and AKT was *dependent* on activation . Positive_regulation EPHB2 JAK1 17550976 1784268 Finally , suppression of by lentiviral delivery of Jak1 short hairpin RNA *blocked* PRL activation of [ERK] and signal transducer and activator of transcription ( Stat ) 3 and suppressed PRL activation of Jak2 , Stat5a , Stat5b , and Akt , as well as tyrosine phosphorylation of PRLR . Positive_regulation EPHB2 JAK1 19046323 2017495 These results indicate that CNTF evoked stimulation of T-type Ca ( 2+ ) channel expression in chicken nodose neurons requires *dependent* [ERK] signaling . Positive_regulation EPHB2 JAK2 11313464 805478 These results indicate that the interaction between TFII-I and [ERK] , which is essential for its activity , can be *regulated* by through phosphorylation of TFII-I at tyrosine 248 . Positive_regulation EPHB2 JAK2 12149229 970254 Our data reveal the requirement of [ERK] *activation* by ( 5-19 ) in Ba/F3 cells and suggest that TEL-JAK2 leukemogenic potential may be mediated in part through ERK1/2 . Positive_regulation EPHB2 JAK2 12955078 1137682 Further biochemical analyses revealed that IL-3 *induced* , [Erk] , and PI3 kinase pathways in SHP-2 ( -/- ) cells were impaired and reintroduction of WT SHP-2 into mutant cells partially restored IL-3 signaling . Positive_regulation EPHB2 JAK2 14551204 1185950 Previous work has shown that inhibition of Jak2 via the pharmacological compound AG490 blocks the angiotensin II (Ang II) dependent activation of ERK2 , thereby suggesting an essential *role* of in [ERK] activation . Positive_regulation EPHB2 JAK2 14551204 1185956 However , recent studies have thrown into question the specificity of AG490 and therefore the *role* of in [ERK] activation . Positive_regulation EPHB2 JAK2 16061232 1442079 Inhibition of TK or activities *blocked* magnolol induced phosphorylation of MEK and [ERK] , again supporting the upstream role of JAK2 . Positive_regulation EPHB2 JAK2 17255201 1725199 Prolactin *induced* phosphorylation of JAK2 and [ERK] , whereas IFN-gamma induced phosphorylation of JAK1 , , and p38 MAPK . Positive_regulation EPHB2 JAK2 17363567 1713060 Leptin induced phosphorylation of [ERK] and AKT was *dependent* on activation . Positive_regulation EPHB2 JAK2 18499741 1939361 , but not Src family kinases , is *required* for STAT , [ERK] , and Akt signaling in response to growth hormone in preadipocytes and hepatoma cells . Positive_regulation EPHB2 JAK2 19046323 2017496 These results indicate that CNTF evoked stimulation of T-type Ca ( 2+ ) channel expression in chicken nodose neurons requires *dependent* [ERK] signaling . Positive_regulation EPHB2 JAK2 19164446 2048419 We previously reported that IRS-1 and associate independently of tyrosine phosphorylation via IRS-1 's N terminus and that IRS-1 reconstitution greatly *enhances* GH-induced [ERK] , but not STAT5 , activation . Positive_regulation EPHB2 JAK2 19508391 2108578 Effects of tripterine were investigated on endothelial barrier function , inducible nitric oxide synthase (iNOS) expression , nicotinamide adenine dinucleotide phasphate ( NADPH) oxidase activity , 3-nitrotyrosine formation , protein phosphatase type 2A (PP2A) activity , *activation* of [extracellular regulated kinase (ERK)] , c-Jun terminal kinase (JNK) and Janus kinase ( ) , and degradation of IkappaB in microvascular endothelial cells exposed to pro-inflammatory stimulus [ lipopolysaccharide (LPS) + interferon gamma (IFNgamma) ] and on vascular permeability in air pouches of mice injected with LPS + IFNgamma . Positive_regulation EPHB2 JAK2 21490369 2448487 GH-induced [ERK] activation was completely *blocked* by the ERK pathway inhibitor , U0126 , and the inhibitor , 1,2,3,4,5,6-hexabromocyclohexane ( Hex ) , and was partially blocked by the PI3K inhibitor LY294002 . Positive_regulation EPHB2 JAK2 22649371 2522757 inhibition completely *blocked* activation of [ERK] , Akt , and STAT5 , suggesting that all of these pathways link to GHR1 and GHR2 via JAK2 . Positive_regulation EPHB2 JAK3 12955078 1137683 Further biochemical analyses revealed that IL-3 *induced* , [Erk] , and PI3 kinase pathways in SHP-2 ( -/- ) cells were impaired and reintroduction of WT SHP-2 into mutant cells partially restored IL-3 signaling . Positive_regulation EPHB2 JAK3 17363567 1713061 Leptin induced phosphorylation of [ERK] and AKT was *dependent* on activation . Positive_regulation EPHB2 JAK3 19046323 2017497 These results indicate that CNTF evoked stimulation of T-type Ca ( 2+ ) channel expression in chicken nodose neurons requires *dependent* [ERK] signaling . Positive_regulation EPHB2 JAK3 19385051 2069300 Therefore , for the first time , we suggest that the inhibitor , WHI-P131 , *inhibits* EGF induced STAT-3 phosphorylation as well as [ERK] phosphorylation . Positive_regulation EPHB2 JUN 10811803 714648 In LAT-deficient mutant Jurkat cells , TCR engagement fails to induce [ERK] activation , Ca ( 2+ ) flux , and *activation* of and NF-AT . Positive_regulation EPHB2 JUN 12057768 952190 Together these data suggest that C5a mediated activation *requires* both the activation of the [ERK] and JNK pathways , whereas activation of the JNK pathway is sufficient to increase AP-1 binding with ADP . Positive_regulation EPHB2 JUN 12070163 975851 Overexpression studies in Jurkat T cells indicate that DGKzeta interferes with TCR induced Ras and [ERK] activation , *induction* , and expression of the activation marker CD69 . Positive_regulation EPHB2 JUN 12208854 998084 Granulocyte/macrophage-colony stimulating factor ( GM-CSF ) regulates lung innate immunity to lipopolysaccharide through [Akt/Erk] *activation* of NFkappa B and in vivo . Positive_regulation EPHB2 JUN 12424250 1036492 ATP failed to stimulate the phosphorylation of [ERK] and c-Jun N-terminal kinase and *activation* of in the p56 ( lck ) -deficient isogenic T cell line JCaM1 , suggesting a critical role for p56 ( lck ) kinase in downstream signaling . Positive_regulation EPHB2 JUN 12514175 1063808 [ERK] activation *induced* , a member of the AP-1 transcription factor family . Positive_regulation EPHB2 JUN 14647418 1210369 These events were accompanied by the caspase independent downregulation of Raf-1 , inactivation of MEK1/2 , [ERK] , Akt , p70S6K , dephosphorylation of GSK-3 , and *activation* of and p38 MAPK . Positive_regulation EPHB2 JUN 14871558 1208259 In contrast , phospho-kinase levels of [ERK] and Akt were increased at 9-10 months , but phospho-kinase levels of *increased* only at 15-20 months ( when cardiomyopathy was fully manifest ) . Positive_regulation EPHB2 JUN 15878976 1445441 Induction of Bcl10 activity caused rapid activation of nuclear factor-kappaB (NF-kappaB) and , but not *activation* of extracellular signal regulated kinase ( [ERK] ) or p38 mitogen activated protein ( MAP ) kinases . Positive_regulation EPHB2 JUN 16600107 1544959 [ERK] and JNK , but not p38 , *mediated* benzo ( a ) pyrene induced cell cycle changes by transactivation in HELF . Positive_regulation EPHB2 JUN 16712891 1589912 In addition , atRA treatment caused a strong and sustained activation of and p38 kinase ( p38 ) , as well as an early but transient *activation* of extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 JUN 17105733 1676610 Thus , IFNgamma induced JAK1- and STAT1 independent activation of the [ERK] mitogen activated protein kinase pathway , phosphorylation of c-Jun , and *activation* of DNA binding , which are important for the induction of a subset of ISGs . Positive_regulation EPHB2 JUN 18435914 1908198 [ERK] signaling regulates tumor promoter *induced* recruitment at the Fra-1 promoter . Positive_regulation EPHB2 JUN 18579320 1935128 Collectively , these data favor the notion that alpha-ZAL antagonizes oxLDL induced upregulation of ET-1 gene expression and secretion via suppression of oxLDL induced ROS accumulation , [ERK] phosphorylation , and *activation* of the endothelial transcriptional factor . Positive_regulation EPHB2 JUN 18982426 2105741 These inhibitory effects were partially inhibited by SB203580 , a specific inhibitor of p38 MAPK , but not by PD98059 , a specific *inhibitors* of extracellular signal regulated kinase ( [ERK] ) , and SP600125 , a specific inhibitor of . Positive_regulation EPHB2 JUN 21311105 2388661 To clarify the signal transduction pathways related to the regulation of the viral genes by alloferon , we confirmed that the calcium influx into BCBL-1 was apparently inhibited by alloferon , which preceded the suppression of the phosphorylation of [ERK] and the *activation* of by TPA . Positive_regulation EPHB2 JUN 22644739 2675872 Gastric mucosal cell proliferation induced by exposure to high transmural pressure may be related to early activation of [ERK] , the induction of c-fos and c-myc , and the *activation* of . Positive_regulation EPHB2 JUN 23770289 2812242 The p21WAF1-specific small interfering RNA inhibited IL-5 induced cell migration , [ERK] activity , MMP-9 expression , and *activation* of NF-?B and in bladder cancer cells . Positive_regulation EPHB2 JUN 9687508 522235 Consistently , MEK induced [ERK] activation in PC12 cells *induces* expression , while JNK signalling does not . Positive_regulation EPHB2 KAT2B 16616457 1569031 PKA not only signals to directly phosphorylate transcription factors like cAMP response element binding protein and to promote by phosphorylating histone H3 , this versatile kinase also *enhances* the activity of the p38 MAPK , [ERK] , and PI3K pathways . Positive_regulation EPHB2 KCNH4 10637505 577446 [ERK] activation *induces* phosphorylation of at multiple S/T-P motifs to high stoichiometry . Positive_regulation EPHB2 KCNH4 11997521 939454 The constitutively active mutant of SHP-2 induces hyper-tyrosyl phosphorylation of FRS-2 alpha but fails to stimulate or potentiate either FGF-2 induced [Erk] activation or *transactivation* . Positive_regulation EPHB2 KCNH4 12008033 940713 We compared the BCR *induced* intracellular [ Ca2+ ] transient , protein tyrosine phosphorylation and [ERK] phosphorylation , furthermore , the activation of and CREB transcription factors . Positive_regulation EPHB2 KCNH4 12684495 1078041 Light pulses during the subjective night rapidly , but transiently , *induce* [P-ERK] , whereas is also induced , albeit with a slower time course . Positive_regulation EPHB2 KCNH4 18463290 1910083 experiments with hBVR nuclear export signal (NES) and nuclear localization signal ( NLS ) mutants demonstrated its critical *role* in the nuclear localization of IGF stimulated [ERK] for activation . Positive_regulation EPHB2 KCNH4 19218240 2054350 The Ras binding domain fused with a CD8alpha-Igalpha chimeric receptor could *induce* prolonged [ERK] phosphorylation , transcriptional activation of , as well as the capping of the receptor in BLNK-deficient B cells . Positive_regulation EPHB2 KCNH8 18443432 1944600 Kaempferol was demonstrated to *induce* sustained [ERK] activation concomitantly with MEK1 and activation , and this kaempferol induced apoptosis was suppressed by treatment with PD98059 , the overexpression of a kinase-inactive ERK mutant , or ERK siRNA . Positive_regulation EPHB2 KDR 12029087 968121 Endostatin blocked VEGF induced tyrosine phosphorylation of and *activation* of [ERK] , p38 MAPK , and p125(FAK) in human umbilical vein endothelial cells . Positive_regulation EPHB2 KDR 12529448 1048810 Removal of caveolin and from caveolae by cholesterol depletion resulted in an increase in both basal and VEGF induced phosphorylation of VEGFR-2 , but *led* to the inhibition of VEGF induced [ERK] activation and endothelial cell migration , suggesting that localization of VEGFR-2 to these domains is crucial for VEGF mediated signaling . Positive_regulation EPHB2 KDR 14704231 1225411 Localization of and PLD2 in endothelial caveolae is *involved* in VEGF induced phosphorylation of MEK and [ERK] . Positive_regulation EPHB2 KDR 14726393 1234966 In contrast , a intracellular inhibitor failed to block KDR nuclear translocation , but *inhibited* the constitutive activation of mitogen activated protein kinase [(MAPK)/Erk] and the phosphatidylinositol 3-kinase/AKT pathways . Positive_regulation EPHB2 KDR 15541367 1336918 Activation and translocation of PKCdelta is necessary for VEGF induced [ERK] *activation* through in HEK293T cells . Positive_regulation EPHB2 KDR 15541367 1336920 PKC specific inhibitors and human PKCdelta knock-down using siRNA method showed that PKCdelta played an important role in induced [ERK] *activation* . Positive_regulation EPHB2 KDR 15541367 1336925 stimulation did not *induce* [ERK] phosphorylation in human PKCdelta-knockdown HEK293T cells , but co-expression of rat PKCdelta-GFP recovered the ERK phosphorylation . Positive_regulation EPHB2 KDR 15541367 1336928 These results indicate that PKCdelta is involved in induced [ERK] *activation* via C1B domain . Positive_regulation EPHB2 KDR 16724983 1565610 Although was phosphorylated in response to VEGF ( > 50 ng/mL ) , phosphorylated [ERK] was not *detected* at these concentrations . Positive_regulation EPHB2 KDR 22362758 2581464 undergoes phosphorylation and *triggers* [pp60src/ERK] ( 1/2 ) activation . Positive_regulation EPHB2 KDR 22659165 2620399 VEGF induces proliferation of human hair follicle dermal papilla cells through *mediated* activation of [ERK] . Positive_regulation EPHB2 KHSRP 21411748 2432083 We show that Trk induced ADAM17 phosphorylation and generation of the ( ICD ) is *required* for neurotrophin induced [Erk] and Akt activation and for neurotrophin dependent survival signaling . Positive_regulation EPHB2 KIDINS220 23359496 2743169 We show that is *required* for TCR induced sustained , but not transient , [Erk] activation . Positive_regulation EPHB2 KIR3DL1 18292496 1872922 In CD158j positive cells , *results* in an enhanced CD3 mediated cell growth and [Erk] phosphorylation . Positive_regulation EPHB2 KITLG 16170339 1517497 These responses correlated with the inhibition of *stimulated* activation of extracellular signal regulated kinase ( [Erk] ) , protein kinase B (PKB) and ribosomal S6 kinase by simvastatin . Positive_regulation EPHB2 KITLG 16498671 1549008 Furthermore , normal donor CD34+ve stem cells were much more sensitive to BAY 43-9006 when [ERK] was *activated* by , compared to PMA . Positive_regulation EPHB2 KITLG 23707526 2806266 mediated Akt and [Erk] *activation* was also elevated by CSK inhibition . Positive_regulation EPHB2 KLF5 17158781 1687871 We show that increases proliferation , transcriptionally up-regulates EGFR , and *activates* [MEK/ERK] signaling , as indicated by increased phosphorylation of MEK and ERK . Positive_regulation EPHB2 KLF5 17158781 1687880 Thus , *regulates* [MEK/ERK] signaling via EGFR and is also downstream of MAPK signaling , providing a novel mechanism for signal amplification or suppression and control of proliferation in basal cells . Positive_regulation EPHB2 KLF5 19411256 2089715 Finally , the *activation* of [ERK] by is very likely through the KLF5 direct target gene FGF-BP in breast cells . Positive_regulation EPHB2 KLK8 21508957 2428623 Stress results in *dependent* cleavage of [EphB2] in the amygdala causing dissociation of EphB2 from the NR1 subunit of the NMDA receptor and promoting membrane turnover of EphB2 receptors . Positive_regulation EPHB2 KLRC1 21321202 2398941 In addition , as in lymphocytes , ligand engagement *stimulates* phosphorylation of JNK and [ERK] in MAP kinase cascades . Positive_regulation EPHB2 KRAS 10092503 600518 Recently , radicicol was reported as an inhibitor of induced [ERK] *activation* . Positive_regulation EPHB2 KRAS 10340949 616233 ( 2 ) active is *sufficient* for [ERK] activation but is insufficient for maximal activation of JNK or p38 ; Positive_regulation EPHB2 KRAS 10402467 628937 and MAP kinase kinase (MEK) were *necessary* and sufficient for uPA induced [ERK] activation and stimulation of cellular migration , as demonstrated in experiments with dominant negative and constitutively active mutants of these signaling proteins . Positive_regulation EPHB2 KRAS 10571061 568490 function was *required* for [ERK] activation by phorbol esters in cardiac myocytes , but not in cardiac fibroblasts . Positive_regulation EPHB2 KRAS 10636931 660197 These data indicate that rPMT employs G ( q/11 ) family heterotrimeric G proteins to induce dependent [Erk] *activation* via protein kinase C-independent `` transactivation '' of the epidermal growth factor receptor . Positive_regulation EPHB2 KRAS 10667210 578487 Treatment of fibroblast cells with this compound had very little effect on mediated *activation* of [ERK] and JUN kinase activities . Positive_regulation EPHB2 KRAS 10749883 698488 These data clearly demonstrate that the alpha-thrombin induced activation coordinately *regulates* [ERK] and PI 3-kinase activities , both of which are required for expression of cyclin D1 protein and progression through G ( 1 ) . Positive_regulation EPHB2 KRAS 10898494 712063 Here , we analyzed the effects of Vav on three known downstream targets of , i. e. *activation* of [ERK] and NFAT , and up-regulation of the activation antigen CD69 . Positive_regulation EPHB2 KRAS 10898494 712077 Conversely , however , dominant negative Vav did not inhibit NFAT and [ERK] activation or CD69 expression *induced* by an active mutant . Positive_regulation EPHB2 KRAS 10962574 727227 These results suggest that Smad4 acts inhibiting *dependent* [Erk] signalling activity in Ras transformed keratinocytes . Positive_regulation EPHB2 KRAS 10976990 729634 In contrast to their implication in epidermal growth factor (EGF) receptor tyrosine kinase signaling , the adaptor protein Shc , the Grb2/Sos complex , and the small G protein were not *involved* in the activation of [Erk] induced by either LPA or PGF2alpha in MC3T3-E1 cells , suggesting that activation of Erk by Gi and Gq protein coupled receptors is Ras independent in these cells . Positive_regulation EPHB2 KRAS 11005808 752485 Surprisingly , a role for in the heat shock response was eliminated by the failure of a dominant negative Ras ( Asn-17 ) mutant to *inhibit* [ERK] MAPK activation and the failure to observe increases in Ras . Positive_regulation EPHB2 KRAS 11018025 752778 Expression of a dominant negative mutant of Ras also did not significantly impair calcium induced ERK activation , indicating that calcium mediated [ERK] activation does not *require* active . Positive_regulation EPHB2 KRAS 11027277 738757 PI3-K and endocytosis may also regulate ERK signaling at a second site downstream of Ras , since both rapid [ERK] activation and the dependent *activation* of the MAP kinase kinase kinase B-Raf are blocked by inhibition of either PI3-K or endocytosis . Positive_regulation EPHB2 KRAS 11088001 764959 We show that the activation of [ERK] via SSTR1 is mediated by the betagamma subunit of a pertussis toxin-sensitive G-protein and *requires* both the small G protein and the serine/threonine kinase Raf-1 . Positive_regulation EPHB2 KRAS 11262176 796250 However , induced *activation* of the mitogen activated protein kinase [ERK] has been suggested to play a critical role in either growth or differentiation in different model systems . Positive_regulation EPHB2 KRAS 11269657 797344 Arsenite inhibits Ras dependent activation of ERK but activates [ERK] in the *presence* of oncogenic in baboon vascular smooth muscle cells . Positive_regulation EPHB2 KRAS 11418608 843263 VPA induced *activation* of [ERK] was blocked by the mitogen activated protein kinase/ERK kinase inhibitor PD098059 and dominant negative and Raf mutants but not by dominant negative stress activated protein kinase/ERK kinase and mitogen activated protein kinase kinase 6 mutants . Positive_regulation EPHB2 KRAS 11574537 882424 NT-stimulated Erk activity requires Ras activation because overexpression of the dominant negative Ras mutant almost completely *inhibits* the [Erk] activation . Positive_regulation EPHB2 KRAS 11681720 873911 Overexpression of dominant negative mutant *suppressed* GH-stimulated [ERK] activation . Positive_regulation EPHB2 KRAS 11682481 888559 In contrast , activation of [ERK] was largely *dependent* on . Positive_regulation EPHB2 KRAS 11791173 901783 Here we determined the efficacy of Shc and N-Shc toward Erk activation in NGF treated PC12 cells , and found that N-Shc transduced *dependent* [Erk] activation less efficiently than Shc . Positive_regulation EPHB2 KRAS 11799108 922215 In contrast , Ras induced focus formation , platelet derived growth factor ( PDGF ) - , or Ras induced phospho-Akt levels and cell adhesion to fibronectin were affected by T35S and Y40C EDMs , whereas PDGF- or *induced* [phospho-Erk] levels were affected only by the T35S EDM , implying that a more limited set of Ras mediated pathways participate in these phenotypes . Positive_regulation EPHB2 KRAS 11821947 908915 To investigate the specific role of A-Raf in this process we generated A-Raf deficient mouse embryonic fibroblasts ( MEFs ) and embryonic stem ( ES ) cells by gene targeting and characterized their ability to undergo proliferation , differentiation , apoptosis , [ERK] *activation* , and transformation by oncogenic and Src . Positive_regulation EPHB2 KRAS 12082537 958581 In exponentially growing cells , oncogenic *had* no effect on proliferation rates , [Erk] phosphorylation , or the level of cyclin D1 , and Ras-induction did not confer serum independent growth . Positive_regulation EPHB2 KRAS 12193071 981002 Thus , p38 MAP kinase stimulation could perhaps partially account for ET-1 contractive properties , whereas ET-1 induced cell proliferation occurs primarily via dependent *activation* of the [ERK] . Positive_regulation EPHB2 KRAS 12364324 1019132 GLP1 stimulated activation of [Erk] is blocked by inhibitors of MEK , but GLP1 does not *induce* the activation of A-Raf , B-Raf , C-Raf , or . Positive_regulation EPHB2 KRAS 12379659 1034800 Moreover , Erbin inhibits the [Erk] *activation* by active , while it fails to do so in the presence of active Raf-1 . Positive_regulation EPHB2 KRAS 12439598 1016860 *mediated* activation of [ERK] by cisplatin induces cell death independently of p53 in osteosarcoma and neuroblastoma cell lines . Positive_regulation EPHB2 KRAS 12439598 1016864 Our results suggest that cisplatin induced activation of [ERK] is *mediated* by . Positive_regulation EPHB2 KRAS 12446729 1037528 dependent [ERK] *activation* by the human G ( s ) -coupled serotonin receptors 5-HT4 ( b ) and 5-HT7 ( a ) . Positive_regulation EPHB2 KRAS 12473665 1055929 *mediated* peak stimulation of [ERK] by PACAP , whereas Rap1 was necessary for the sustained activation phase . Positive_regulation EPHB2 KRAS 12600818 1085058 was *required* for maximal activation of extracellular signal regulated kinase ( [ERK] ) and Jun amino terminal kinase (JNK) as well as AP-1 and NF-kappaB transcriptional activities , but not for activation of IkappaB kinase (IKK)-beta , an upstream activator of NF-kappaB . Positive_regulation EPHB2 KRAS 12706116 1082481 In PC12 cells , NGF and EGF induce a rapid translocation of [GFP-Erk] that *requires* and Mek . Positive_regulation EPHB2 KRAS 12855697 1134965 This unresponsiveness is associated with the constitutive activation of the small G protein , Rap1 , and the lack of *dependent* activation of [ERK] . Positive_regulation EPHB2 KRAS 12902401 1121106 LPA induced chemotaxis is markedly dependent on activation of PTX-sensitive heterotrimeric G-proteins , on *activation* of the small GTPases , Rac and RhoA , and on GTPase dependent activation of [ERK] . Positive_regulation EPHB2 KRAS 12966092 1164378 EGFR phosphorylation , in turn , led to *dependent* [Erk] activation . Positive_regulation EPHB2 KRAS 12975377 1164602 This inhibition is specific to Cot , because *induced* [ERK] and IkappaB kinase induced NF-kappaB activation are not significantly affected by hKSR-2 co-expression . Positive_regulation EPHB2 KRAS 14607972 1162188 Functionally , Rap1 either interferes with mediated [ERK] *activation* or activates ERK independently of Ras in a cell-context dependent manner . Positive_regulation EPHB2 KRAS 15029245 1228105 Developmentally regulated *role* for in coupling NMDA glutamate receptors to Ras , [Erk] and CREB . Positive_regulation EPHB2 KRAS 15062121 1230751 Signal transduction : implications for *dependent* [ERK] signaling . Positive_regulation EPHB2 KRAS 15516985 1343130 was also constitutively active in patient NK cells , and exposure of cells to the Ras inhibitor FTI2153 or to dominant-negative-Ras *resulted* not only in [ERK] inhibition but also in enhanced apoptosis in both the presence and absence of anti-Fas . Positive_regulation EPHB2 KRAS 15630138 1362337 The Sprouty related Ena/VASP homology 1-domain containing protein ( Spred)-1 has recently been identified as a negative regulator of growth factor mediated , *dependent* [ERK] activation . Positive_regulation EPHB2 KRAS 16041367 1437717 Prohibitin is required for *induced* [Raf-MEK-ERK] activation and epithelial cell migration . Positive_regulation EPHB2 KRAS 16088958 1460661 Inhibition of significantly *blocked* the activation of Raf-1 , [ERK] , and c-Jun and the stimulation of COX-2 expression in response to serum . Positive_regulation EPHB2 KRAS 16170339 1517499 Downregulation of either H- or by RNA interference ( RNAi ) did not *impair* [Erk] activation by growth factors , whereas an RNAi specific for N-Ras inhibited activation of Erk , PKB and SCLC cell growth . Positive_regulation EPHB2 KRAS 16214133 1468840 In addition , transfection of ES cells with DN-Src , or DN-Ras partially inhibited 8-Br-cAMP induced ERK1/2 and consequently PLD activation , whereas cotransfection of DN-Src and DN-Ras completely inhibited ERK1/2 and PLD activation , suggesting that Src and independently *regulate* [ERK/PLD] activation . Positive_regulation EPHB2 KRAS 16214133 1468896 Taken together , these results demonstrate a novel pathway in ES cells that 8-Br-cAMP activate PLD through PKA and ERK1/2 and this [ERK/PLD] activation by 8-Br-cAMP is *mediated* by Src and , separately . Positive_regulation EPHB2 KRAS 16267393 1479012 A substitution that mimics constitutive phosphorylation ( S518D ) abrogated the ability of merlin to suppress effects of the Ras-ERK signaling pathway such as Ras induced SRE transactivation , Elk mediated SRE transactivation , *induced* [ERK] phosphorylation and Ras induced focus formation . Positive_regulation EPHB2 KRAS 16301319 1511018 It inhibits mediated *activation* of [ERK] in response to growth factors . Positive_regulation EPHB2 KRAS 16436505 1540512 In addition , we demonstrated that Tat activation of , but not of Rac , *induces* [ERK] phosphorylation . Positive_regulation EPHB2 KRAS 16478791 1528369 APC inhibits [ERK] pathway activation and cellular proliferation *induced* by . Positive_regulation EPHB2 KRAS 16478791 1528391 The GTP loading and the protein level of mutated RAS were decreased in cells with reduced ERK activity as a result of APC overexpression , indicating that APC regulates *induced* [ERK] activation at least partly by reduction of the RAS protein level . Positive_regulation EPHB2 KRAS 16709153 1598863 However , a biochemical link between PE and GAP inactivation is missing and GEF stimulation is hard to reconcile with the observation that dominant negative S17N-Ras does not compromise *dependent* [ERK] ( extracellular-signal regulated kinase ) activation by PE . Positive_regulation EPHB2 KRAS 16860436 1632242 Inhibitors of epidermal growth factor receptor (EGFR) ( AG 1478 ) , and Raf , as well as antioxidants *inhibited* activation of [ERK] and Akt , while the Src inhibitor PP2 had no effect . Positive_regulation EPHB2 KRAS 16959871 1646779 Overexpression of G ( alpha- ) transducin , showed that G ( betagamma ) -subunit activation is only partially required for ERK1/2 phosphorylation and does not play a role in p38 MAPK phosphorylation , whereas overexpression of a dominant negative ( Ras N17 ) *attenuated* both [ERK] and p38 MAPK activation . Positive_regulation EPHB2 KRAS 17045653 1666544 In the present study , we investigated the *role* of in FLG- and LPS mediated signaling in [ERK] activation in chicken heterophils . Positive_regulation EPHB2 KRAS 17174095 1688101 Kinase Suppressor of Ras (KSR) is a molecular scaffold that interacts with the core kinase components of the ERK cascade , Raf , MEK , and ERK and provides spatial and temporal regulation of *dependent* [ERK] cascade signaling . Positive_regulation EPHB2 KRAS 17192389 1724638 Comparison of wild-type and Kras ( G12D ) c-kit ( + ) lin ( -/low ) cells shows that ( G12D ) expression causes hyperproliferation in vivo and *results* in abnormal levels of phosphorylated STAT5 , [ERK] , and S6 under basal and stimulated conditions . Positive_regulation EPHB2 KRAS 17374607 1734754 Axin inhibits cellular proliferation and [ERK] pathway activation *induced* by either epidermal growth factor or , indicating a role of Axin in the regulation of growth induced by ERK pathway activation . Positive_regulation EPHB2 KRAS 17440079 1729377 Moreover , although the initial activation of Ras and PAK2 are distinctly regulated , TGF-beta stimulated PAK2 activity is required for *dependent* [ERK] phosphorylation and Elk-1 transcription . Positive_regulation EPHB2 KRAS 17450518 1761003 HUVEC stably transfected with dominant negative Ras abrogated XIAP preservation by cPGI ( 2 ) while constitutive active *increased* [ERK] phosphorylation and protected XIAP from degradation . Positive_regulation EPHB2 KRAS 17562163 1798034 Inhibitors of growth factor receptor ( AG1478 ) and Src ( PP2 ) and the antioxidant N-acetylcysteine did not affect activation of ERK and Akt , while the and Raf inhibitors *inhibited* activation of [ERK] , but not Akt . Positive_regulation EPHB2 KRAS 18275061 1924758 As further support for Ras mediated signaling , constitutively active ( ca ) *promoted* [MEK/ERK] activation and osteoclast survival , which was blocked by inhibition of PI3K or Raf . Positive_regulation EPHB2 KRAS 18604197 1941627 Thus , IQGAP3 regulates the promotion of cell proliferation through *dependent* [ERK] activation . Positive_regulation EPHB2 KRAS 19351816 2057685 Oncogenic *requires* simultaneous PI3K signaling to induce [ERK] activation and transform thyroid epithelial cells in vivo . Positive_regulation EPHB2 KRAS 20179705 2222197 Induction of [ERK] signalling requires direct binding of the drug to the ATP binding site of one kinase of the dimer and is *dependent* on activity . Positive_regulation EPHB2 KRAS 20452986 2282978 In this study we tested if activation of [ERK] and cPLA(2) occurred as a *result* of signaling during infection and determined the relative contribution of these signaling components to chlamydial replication and survival . Positive_regulation EPHB2 KRAS 21330403 2420298 Measurements of the dephosphorylation of [ERK] and the *activation* of showed that the ROS scavenger prevents the cAMP provoked activation of Ras and that cAMP , with or without a ROS scavenger , has little or no effect on the dephosphorylation of ERK . Positive_regulation EPHB2 KRAS 21678474 2483650 Furthermore , we demonstrate the mechanism for PLD1 activation of [ERK] *involves* . Positive_regulation EPHB2 KRAS 21949793 2488010 Like costimulation via CD28 , active *induced* AKT , JNK and [ERK] phosphorylation . Positive_regulation EPHB2 KRAS 22592532 2614451 To do so , we determined the role of CaMKII in Raf-1 and [ERK] *activation* by oncogenic and other factors . Positive_regulation EPHB2 KRAS 22592532 2614455 Serum , fibronectin , Src ( Y527 ) and ( V12 ) *activated* CaMKII and [ERK] , at different extents . Positive_regulation EPHB2 KRAS 22975374 2673977 Without EGFR activity , active levels are not *sufficient* to induce robust [MEK/ERK] activity , a requirement for epithelial transformation . Positive_regulation EPHB2 KRAS 23455880 2781792 The grade of resistance appears to correlate with the individual *dependent* intrinsic activation of [ERK] . Positive_regulation EPHB2 KRAS 23893412 2839579 The first step of dependent *activation* of [ERK] signaling is Ras binding to members of the Raf family of MAP kinase kinase kinases , C-Raf and B-Raf . Positive_regulation EPHB2 KRAS 23893412 2839596 Both B-Raf and C-Raf were constitutively bound to oncogenic Ras and contributed to dependent [ERK] *activation* . Positive_regulation EPHB2 KRAS 23893412 2839602 cAMP inhibited the growth of H1299 cells and dependent [ERK] *activation* via PKA . Positive_regulation EPHB2 KRAS 24327733 2880370 Unexpectedly , we found that in PIK3CA mutant and HER2 amplified breast cancers sensitive to PI3K inhibitors , PI3K inhibition led to a rapid suppression of Rac1/p21 activated kinase (PAK)/protein kinase C-RAF ( C-RAF ) / protein kinase MEK ( MEK ) [/ERK] signaling that did not *involve* . Positive_regulation EPHB2 KRAS 24711380 2935545 It is known that Erbin inhibits mediated *activation* of the extracellular signal regulated kinase ( [ERK] ) by binding to Soc-2 suppressor of clear homolog ( Shoc2 ) . Positive_regulation EPHB2 KRAS 25002533 2952822 These data show that caveolin-1 is necessary for optimal KSR1 dependent [ERK] *activation* by growth factors and oncogenic . Positive_regulation EPHB2 KRAS 25086185 2956925 Intriguingly , mediated [ERK] *activation* was dependent on N-Ras . Positive_regulation EPHB2 KRAS 9309148 454738 Treatment of fibroblast cells with this compound had very little effect on *mediated* activation of [ERK] and Jun kinase activities . Positive_regulation EPHB2 KRAS 9399643 469205 Treatment of fibroblast cells with this compound had very little effect on *mediated* activation of [ERK] and JUN kinase activities . Positive_regulation EPHB2 KRAS 9407076 470810 We have shown previously that *stimulated* [ERK] activation is essential for the induction and continued G1 expression of cyclin D1 . Positive_regulation EPHB2 KRAS 9632795 513078 These observations suggest that Gab1 acts as an adapter molecule in transmitting signals to ERK MAP kinase for the cytokine receptor gp130 and that SHP-2 , PI-3 kinase , and are *involved* in Gab1 mediated [ERK] activation . Positive_regulation EPHB2 KRAS 9774335 539659 Surprisingly , activation of endogenous Rap1 fails to affect dependent [ERK] *activation* . Positive_regulation EPHB2 KRAS 9892010 586557 We show that the activation of [ERK] via SSTR1 is pertussis toxin sensitive and *requires* the small G protein , phosphatidylinositol 3-kinase , the serine/threonine kinase Raf-1 , and the protein tyrosine phosphatase SHP-2 . Positive_regulation EPHB2 KRR1 16291755 1510583 However , neither nor TRAF2 overexpression was *sufficient* to activate Tpl2 and [ERK] . Positive_regulation EPHB2 KRT15 20534855 2289666 Through conserved binding motifs , such as Src homology 2 (SH2) and SH3 binding sites , interacts with cellular proteins , *activates* the NF-kappaB , [MEK/Erk] , and Jun N-terminal protein kinase (JNK) pathways , and induces the expression of several inflammatory and angiogenic genes . Positive_regulation EPHB2 KRT25 24523415 2924176 Additionally , we detected that both NMDA and *increased* [ERK] activity with a similar time-course . Positive_regulation EPHB2 KRT8 15763073 1383343 Requirement for [ERK] activation in acetone extract identified from Bupleurum scorzonerifolium *induced* A549 tumor cell apoptosis and phosphorylation . Positive_regulation EPHB2 KSR1 15371409 1334226 is a molecular scaffold that interacts with the components of the Raf/MEK/ERK kinase cascade and positively *regulates* [ERK] signaling . Positive_regulation EPHB2 KSR1 15899786 1408732 These results indicate that *mediated* regulation of [ERK] activity represents a novel determinant of CDDP sensitivity of cancer cells . Positive_regulation EPHB2 KSR1 17056543 1636587 The MAPK scaffold is *involved* in [ERK] activation by stress and proinflammatory cytokines and induction of arthritis . Positive_regulation EPHB2 KSR1 17056543 1636591 Although the scaffold kinase suppressor of Ras (KSR)1 is required for efficient Erk activation by mitogenic stimuli , the *role* of in [ERK] activation by inflammatory and stress stimuli is unknown . Positive_regulation EPHB2 KSR1 17174095 1688106 Moreover , we find that the interaction is *required* for KSR1 to maximally facilitate [ERK] cascade signaling and contributes to the regulation of Raf kinase activity . Positive_regulation EPHB2 KSR1 18952605 2001055 Overexpression of the mutant in HIRcB cells *inhibited* insulin dependent MEK and [ERK] phosphorylation . Positive_regulation EPHB2 KSR1 19147494 2043007 is *required* for maximal [ERK] activation induced by growth factors and by some cytotoxic agents . Positive_regulation EPHB2 KSR1 19147494 2043008 We show here that is also *required* for maximal [ERK] activation induced by UV light , ionizing radiation , or the DNA interstrand cross linking agent mitomycin C ( MMC ) . Positive_regulation EPHB2 KSR1 20865788 2343014 is *required* for full [ERK] activation in thymocytes but not for thymocyte selection . Positive_regulation EPHB2 KSR1 20865788 2343015 The scaffold protein is *critical* for efficient activation of [ERK] in a number of cell types . Positive_regulation EPHB2 KSR1 23221422 2711107 also *enhances* [Raf-1/MEK/ERK] signaling and is involved in a variety of cellular responses , including cell differentiation , proliferation , and apoptosis . Positive_regulation EPHB2 KSR1 25002533 2952819 The interaction between and caveolin-1 is *essential* for optimal activation of [ERK] as a KSR1 mutant unable to interact with caveolin-1 does not efficiently mediate growth factor induced ERK activation at the early stages of pathway activation . Positive_regulation EPHB2 KSR1 25002533 2952823 These data show that caveolin-1 is necessary for optimal *dependent* [ERK] activation by growth factors and oncogenic Ras . Positive_regulation EPHB2 L1CAM 24974583 2947615 Inhibition of expression by L1CAM-specific siRNA *suppressed* the activation of MAPKs such as [ERK] and p38 . Positive_regulation EPHB2 LAG3 21441454 2417081 Interaction of with MHC II expressed on melanoma cells *upregulates* both [MAPK/Erk] and PI3K/Akt pathways , albeit with different kinetics . Positive_regulation EPHB2 LAMTOR3 15923628 1414011 Here we show that the putative scaffold protein and its partner p14 *regulate* PAK1 dependent [ERK] activation during adhesion and cell spreading but are not required for ERK activation by platelet derived growth factor . Positive_regulation EPHB2 LAMTOR3 19930650 2171994 Here we test the hypothesis that *dependent* [ERK] signaling regulates motility of DU145 prostate cancer cells . Positive_regulation EPHB2 LAMTOR3 21829671 2468259 In contrast , [ERK] *activation* by is additive to that of KSR but it shows little ligand-sensitivity under high levels of EGF . Positive_regulation EPHB2 LAT 10360968 619754 is also *required* for [Erk] activation , CD69 up-regulation , and AP- and NFAT mediated gene transcription . Positive_regulation EPHB2 LAT 12817019 1103577 Because TCR activates ERK via SLP-76 mediated activation of the linker of activated T cells (LAT) scaffold protein , we examined the *role* of in SDF-1alpha mediated [ERK] activation . Positive_regulation EPHB2 LAT 17119112 1700616 Although RhoH is not required for TCR induced activation of ZAP70 and ZAP70 mediated activation of p38 , it is crucial for the tyrosine phosphorylation of , PLCgamma1 , and Vav1 and for the *activation* of [Erk] and calcium influx . Positive_regulation EPHB2 LAT 19717519 2133536 TCR activation in double positive cells with stabilized beta-catenin triggered signaling associated with negative selection , including sustained overactivation of and Jnk and a transient *activation* of [Erk] . Positive_regulation EPHB2 LAT2 19879355 2184488 *regulates* [ERK] activation in Helicobacter pylori infected epithelial cells . Positive_regulation EPHB2 LBP 22921303 2666723 The can also *activate* [ERK] , which may be associated with p53 pathway . Positive_regulation EPHB2 LCK 22123847 2542180 Instead , Nef triggers *dependent* activation of TGN associated [Ras-Erk] signaling to promote the production of the T lymphocyte survival factor IL-2 and to enhance virus spread . Positive_regulation EPHB2 LCP2 11390650 822687 The P-1 domain mediates a constitutive interaction of with the SH3 domain of PLC-gamma1 and is *required* for TCR mediated activation of [Erk] , PLC-gamma1 , and NFAT ( nuclear factor of activated T cells ) . Positive_regulation EPHB2 LCP2 16439309 1516602 Expression of *had* no discernable effect on RA-induced [ERK] activation , subsequent functional differentiation , or the rate of RA-induced G0 arrest . Positive_regulation EPHB2 LCP2 16439309 1516604 now *enhanced* RA-induced [ERK] activation , compared to parental c-FMS transfectants . Positive_regulation EPHB2 LCP2 22902619 2682940 Loss of Lys-30 ubiquitination of *results* in enhanced anti-CD3 antibody induced [ERK] and JNK activation . Positive_regulation EPHB2 LDLR 9392422 467752 Moreover , pretreatment of cells with calphostin C inhibited TPA mediated [ERK] activation and mRNA *induction* in a dose dependent fashion . Positive_regulation EPHB2 LEO1 11934880 953473 In contrast , these inhibitors almost completely blocked both *induced* [ERK] phosphorylation and LTC ( 4 ) generation in PAFR cells . Positive_regulation EPHB2 LEO1 11934880 953478 However , in mPAFR cells pertussis toxin only partially inhibited *induced* [ERK] phosphorylation . Positive_regulation EPHB2 LEO1 11934880 953483 A Ca ( 2+ ) /calmodulin inhibitor had no effect on *induced* [ERK] phosphorylation in PAFR cells but completely blocked the response in mPAFR cells . Positive_regulation EPHB2 LEO1 12687020 1078716 *activated* three prominent mitogen activated protein kinase modules ( [ERK] , p38MAPK and Jun N-terminal kinases ) in these cells , inhibited proliferation and induced differentiation ( measured by the induction of Waf1/p21 and the induction of the differentiation related marker CEA ) . Positive_regulation EPHB2 LEO1 15115659 1241554 These results indicate that *induced* activation of [ERK] contributes to both the expression of the pro-adhesive phenotype and repression of neutrophil apoptosis , thereby amplifying the inflammatory response . Positive_regulation EPHB2 LEO1 15917990 1413204 *induced* [ERK] phosphorylation is mediated by PI3K , PKC , PLA2 , PLC , and extracellular calcium , whereas fMLP induced ERK phosphorylation does not involve the PKC-gamma isoform and extracellular calcium . Positive_regulation EPHB2 LEO1 20074623 2218626 These results suggest that *induces* synaptic facilitation through activation of CaMKII , PKC and [ERK] in the hippocampal CA1 region . Positive_regulation EPHB2 LEO1 23911909 2840518 Likewise , ERK phosphorylation was markedly enhanced in PAF stimulated VSMCs , and this was attenuated by WEB2086 , but not by EGF receptor inhibitor , demonstrating the specificity of PAF receptor (PAFR) in *induced* [ERK] phosphorylation . Positive_regulation EPHB2 LEO1 23911909 2840524 In addition , *induced* [ERK] phosphorylation and MMP-2 production were significantly attenuated by ß-arrestin2 depletion . Positive_regulation EPHB2 LEO1 9878562 557853 Stimulation of receptor *induces* activation of extracellular signal regulated kinase ( [ERK] ) and cytosolic phospholipase A2 (cPLA2) and release of arachidonic acid in Chinese hamster ovary cells . Positive_regulation EPHB2 LEO1 9915820 587192 The *induced* p38 and [ERK] pathways appeared to be preferentially regulated by RGS16 and RGS1 , respectively . Positive_regulation EPHB2 LEP 11085989 810050 Divergent roles of SHP-2 in [ERK] *activation* by receptors . Positive_regulation EPHB2 LEP 11085989 810056 We show that a catalytically inactive mutant of SHP-2 blocks *stimulated* [ERK] phosphorylation by the long leptin receptor , ObRb . Positive_regulation EPHB2 LEP 11606454 871810 Nicardipine and omega-conotoxin GVIA , each at 1 microM , were effective at inhibiting *induced* TH enzyme activity , TH mRNA accumulation , PKC activity , and [ERK] activity . Positive_regulation EPHB2 LEP 11606454 871811 The present study also showed that H89 ( a PKA inhibitor ) moderately , but significantly , inhibited *induced* [ERK] and TH mRNA . Positive_regulation EPHB2 LEP 12049654 950320 *induced* [ERK] activation in J774.2 cells shows a biphasic pattern , with an initial reduction in ERK phosphorylation for up to 10 min following leptin stimulation , while at later time points phosphorylation of ERK was increased above basal levels . Positive_regulation EPHB2 LEP 12665505 1092874 *activated* [ERK] , but not p38 and JNK , and up-regulated cPLA2 activity ; Positive_regulation EPHB2 LEP 16052473 1447810 A functional leptin receptor was demonstrated by an acute *induced* 1.5-fold increase in [ERK] activity ( P = 0.029 ) . Positive_regulation EPHB2 LEP 17363567 1713062 *induced* phosphorylation of [ERK] and AKT was dependent on Janus activated kinase (JAK)/STAT activation . Positive_regulation EPHB2 LEP 17618045 1774829 synergistically *enhanced* acid stimulated EGFR and [ERK] phosphorylation but did not further increase JNK or p38 MAP kinase phosphorylation . Positive_regulation EPHB2 LEP 18206959 1863938 *increased* [ERK] phosphorylation level in renal and aortic tissues more markedly after 4 than after 8 days of treatment . Positive_regulation EPHB2 LEP 19066310 2035567 Hypothalamic [ERK] *mediates* the anorectic and thermogenic sympathetic effects of . Positive_regulation EPHB2 LEP 19524014 2116203 We did not observe any changes in Sam68 Ser/Thr phosphorylation but using the specific MEK1 inhibitor PD-98059 showed that mediated [ERK] *activation* is essential for leptin 's effect on OB-Rb mRNA expression . Positive_regulation EPHB2 LEP 22431513 2588289 Biochemical analyses showed a physical association of Shp2 with estrogen receptor alpha , which is necessary for the synergistic and persistent *activation* of [Erk] by and estrogen . Positive_regulation EPHB2 LEP 23358729 2738817 Pretreatment of breast cancer cells with adiponectin protects against *induced* activation of [ERK] and Akt . Positive_regulation EPHB2 LEP 24213635 2886021 In the xenograft mouse model the leptin level was increased and *increased* the phosphorylation of [ERK] in the MCF-7 cells , whereas LA significantly reduced the phosphorylation of ERK . Positive_regulation EPHB2 LEP 24248461 2903306 Silencing of the leptin receptor OB-Rb with small interfering RNA abolished induced *activation* of [ERK] and Akt and the expression of RANKL and reversed the effects of leptin on ALP activity . Positive_regulation EPHB2 LEPR 22685316 2621044 Ablation of mediated [ERK] *activation* impairs host defense against Gram negative pneumonia . Positive_regulation EPHB2 LEPR 22685316 2621046 In this report , we assessed mediated [ERK] *activation* , a pathway that was ablated in the l/l mouse through a mutation of the tyrosine 985 residue in the leptin receptor , to determine its role in host defense against bacterial pneumonia in vivo and in alveolar macrophage ( AM ) antibacterial functions in vitro . Positive_regulation EPHB2 LEPR 22685316 2621047 These results demonstrate that mediated [ERK] *activation* plays an essential role in host defense against bacterial pneumonia and in leukocyte antibacterial effector functions . Positive_regulation EPHB2 LGALS3 19940114 2198832 Moreover , consistently *enhanced* [ERK] activation . Positive_regulation EPHB2 LIF 11855863 914277 In contrast , does not *activate* STAT3 , [ERK] , or the gp130 receptor in human N tera-2/D1 EC cells , although all receptor components are expressed . Positive_regulation EPHB2 LIF 12791646 1133995 *stimulated* phospho-Stat3 ( known to be critical for ES cell self-renewal and maintenance of an undifferentiated state ) and [phospho-Erk] levels were examined by immunoblotting . Positive_regulation EPHB2 LIF 15330857 1287710 Disruption of lipid rafts by MBCD inhibited induced [ERK] *activation* but not STAT3 activation . Positive_regulation EPHB2 LIF 16169879 1457108 *induced* [ERK] activation was also abolished in PDMP treated NECs , suggesting that PDMP specifically represses the Ras-MAPK pathway . Positive_regulation EPHB2 LIF 22528752 2618584 We recently found that while signaling *augments* [ERK] activity , BMP signaling inhibits ERK activity in mouse ES cells via direct upregulation of an ERK phosphatase-dual-specificity phosphatase 9 . Positive_regulation EPHB2 LIF 24051329 2857434 Interestingly , B-Raf and C-Raf double knockdown , not A-Raf and B-Raf knockdown , inhibited the maximal [ERK] activation *induced* by , concomitant with the slower growth of ES cells . Positive_regulation EPHB2 LPA 10594782 573165 also *stimulated* [ERK] activity ( peak at 5 min , return to baseline by 60 min ) maximally at a dose of 100 microM LPA . Positive_regulation EPHB2 LPA 10594782 573166 [ERK] *activation* by was not affected by pretreatment with wortmannin or by the expression of Deltap85 . Positive_regulation EPHB2 LPA 10688043 669949 In the androgen-insensitive cell line , PC-3 , EGF- and *induced* [ERK] phosphorylation and cell proliferation . Positive_regulation EPHB2 LPA 10976990 729635 In contrast to their implication in epidermal growth factor (EGF) receptor tyrosine kinase signaling , the adaptor protein Shc , the Grb2/Sos complex , and the small G protein Ras were not involved in the activation of [Erk] *induced* by either or PGF2alpha in MC3T3-E1 cells , suggesting that activation of Erk by Gi and Gq protein coupled receptors is Ras independent in these cells . Positive_regulation EPHB2 LPA 11243883 792270 Moreover , accumulation of phosphatidic acid ( PA ) , a product of PLD action , potentiated the *induced* [ERK] activation in GP-PLD1 cells while blocking of PA production with the treatment of 1-butanol attenuated LPA induced ERK phosphorylation . Positive_regulation EPHB2 LPA 12069816 955546 In the last several years , the epidermal growth factor (EGF) receptor has been recognized as a protein tyrosine kinase that plays a central role in mediating *induced* tyrosine phosphorylation and [Erk] MAP kinase activation . Positive_regulation EPHB2 LPA 12069837 955596 Further , *induced* [ERK] activation involves matrix metalloproteinases ( MMPs ) , which cause the release of active EGFR ligands . Positive_regulation EPHB2 LPA 12730329 1112884 This functional inhibition of either Gi or Ras failed , however , to affect the *induced* [ERK-phosphorylation] . Positive_regulation EPHB2 LPA 12730329 1112887 Surprisingly , functional inhibition of Rho-GTPase , in C3-exotoxin lipofected cells , markedly reduced *stimulated* phosphorylation of [ERK] , without affecting the EGF induced stimulation of MAPK . Positive_regulation EPHB2 LPA 12730329 1112901 The findings indicate that transiently *stimulates* MAPK [ERK] in LPA1/edg2 expressing theca cells and suggest an alternative mechanism regulating the activation of ERK that differs from the canonical EGF-Ras-MAPK kinase pathway . Positive_regulation EPHB2 LPA 12890682 1142941 The mediated *activation* of [ERK] and tyrosine phosphorylation of PDGF-R beta was attenuated by tyrphostin AG 1296 , an inhibitor of PDGF-R kinase , suggesting transactivation of PDGF-R by LPA . Positive_regulation EPHB2 LPA 12902401 1121133 induced ERK activation *results* in a transient translocation of the phosphorylated [ERK] to newly forming focal contact sites at the leading edge of the migrating cells . Positive_regulation EPHB2 LPA 14657000 1202028 We investigated this crosstalk under different conditions and found that both Akt and [ERK] activation *induced* by S1P , but not , in HEY ovarian cancer cells required PDGFR but not epidermal growth factor receptor (EGFR) or insulin-like growth factor-I receptor ( IGFR ) . Positive_regulation EPHB2 LPA 15143197 1247484 In addition , NHERF2 increases *induced* [ERK] activation , which is followed by cyclooxygenase-2 induction via a PLC dependent pathway . Positive_regulation EPHB2 LPA 15194005 1259722 Pertussis toxin (PTX) did not affect on the *induced* early gene induction and [ERK] activation , ruling out the role of Gi/o protein ( s ) in the process . Positive_regulation EPHB2 LPA 15262179 1274626 Since we recently demonstrated that high-density *induced* human coronary artery endothelial cell ( HCEC ) tube formation through [Ras/Raf/ERK] ( extracellular-signal regulated kinase ) activation [ Arterioscler . Positive_regulation EPHB2 LPA 15494214 1354848 *Activation* of [ERK] by phenylephrine and occurs in a dose- and time dependent manner . Positive_regulation EPHB2 LPA 15988003 1429179 However , it abolishes the association of TRIP6 with Crk and p130cas in cells and significantly reduces the function of TRIP6 to promote *induced* [ERK] activation . Positive_regulation EPHB2 LPA 16242672 1483692 Pertussis toxin almost completely inhibited the *induced* cellular proliferation and [ERK] activation , indicating the role of G ( i/o ) protein ( s ) in the processes . Positive_regulation EPHB2 LPA 16527839 1561692 , but not ANP , *enhances* [ERK] phosphorylation and induces cell rounding together with a dramatic reorganization of actin filaments . Positive_regulation EPHB2 LPA 16760261 1624945 Pertussis toxin (PTX) blocks *induced* activation of p38 and [ERK] but only slightly inhibits LPA induced activation of Akt . Positive_regulation EPHB2 LPA 16760261 1624950 *induced* activations of p38 , [ERK] , and Akt kinases , as well as proliferation , are inhibited by Ki16425 . Positive_regulation EPHB2 LPA 16904289 1672818 MAGI-3 regulates *induced* activation of [Erk] and RhoA . Positive_regulation EPHB2 LPA 16904289 1672826 Overexpression of MAGI-3 in SW480 cells showed no apparent effect on *induced* activation of [Erk] and Akt . Positive_regulation EPHB2 LPA 16904289 1672831 In contrast , silencing of MAGI-3 expression by siRNA drastically inhibited *induced* [Erk] activation , suggesting that the lack of an effect by overexpression was due to the high endogenous MAGI-3 level in these cells . Positive_regulation EPHB2 LPA 17057224 1654597 These included decreased induced *activation* of [ERK] and Rho , and the basal activities of Rac and Cdc42 . Positive_regulation EPHB2 LPA 17337598 1765815 Additionally , [ERK] phosphorylation is enhanced in the *presence* of in WT Hic-5 cells . Positive_regulation EPHB2 LPA 17337598 1765816 A pharmacological inhibitor of MEK activity inhibits *stimulated* WT Hic-5 cell migration and [ERK] phosphorylation , suggesting Hic-5 enhances migration via MEK activation of ERK . Positive_regulation EPHB2 LPA 17937769 1813788 Furthermore , *induced* [ERK] activation was found to be independent of matrix metalloproteinases ; Positive_regulation EPHB2 LPA 18027882 1894634 *induced* activation of [ERK] through pertussis toxin-sensitive manner , and pretreatment of MSCs with U0126 , a MEK inhibitor , or pertussis toxin attenuated the LPA induced migration . Positive_regulation EPHB2 LPA 19077254 2003174 and S1P also *induce* p44/42 [ERK] MAP kinase phosphorylation in these cells and stimulate cell proliferation via G i/o coupled receptors in an Epidermal Growth Factor Receptor (EGFR)- and ERK dependent pathway . Positive_regulation EPHB2 LPA 19116446 2004678 Higher expression of LPA2 mRNA was observed in CAOV-3 cells , and transfection of the cells with a selective LPA2 siRNA significantly inhibited induced *activation* of EGFR and [ERK] , as well as COX-2 expression . Positive_regulation EPHB2 LPA 19208746 2039238 Both and S1P *activated* PI3K , [Ras/ERK] , and Rho/Rho kinase pathways , leading to migration , G ( 1 ) -S cell cycle progression , and stress fiber formation , respectively . Positive_regulation EPHB2 LPA 19208746 2039244 Although and S1P *activated* both PI3K/Akt and [Ras/ERK] signaling through G ( i ) , anastellin inhibited only the Ras/ERK pathway . Positive_regulation EPHB2 LPA 19609315 2182806 *induced* [ERK] phosphorylation was also strongly EGFR and MP dependent and markedly inhibited by neutralization of HB-EGF . Positive_regulation EPHB2 LPA 20934509 2353542 Exogenous further *stimulated* [ERK] and Akt phosphorylation and NF-?B activity . Positive_regulation EPHB2 LPA 21209852 2359313 also *increased* [ERK] activity and the MEK inhibitor U0126 could block LPA induced ERK activity and cell migration . Positive_regulation EPHB2 LPA 21209852 2359333 Furthermore , LPA increased PI3K activity , and the PI3K inhibitor LY294002 inhibited both induced [PAK1/ERK] *activation* and cell migration . Positive_regulation EPHB2 LPA 21209852 2359337 Moreover , in the breast cancer cell , LPA treatment resulted in remarkable production of reactive oxygen species ( ROS ) , while *induced* ROS generation , [PI3K/PAK1/ERK] activation and cell migration could be inhibited by N-acetyl-L-Cysteine , a scavenger of ROS . Positive_regulation EPHB2 LPA 21209852 2359341 These data also suggest that ROS generation plays an essential role in the activation of *stimulated* [PI3K/PAK1/ERK] signaling and breast cancer cell migration . Positive_regulation EPHB2 LPA 21244430 2397884 However , the IL-1ß treatment had no appreciable effect on LPA ( 1 ) receptor mRNA expression and *induced* activation of [ERK] , Akt , and proliferation . Positive_regulation EPHB2 LPA 22797060 2785913 In addition , tumor cell cultures derived from CD97 transgenic as compared with non-transgenic mice demonstrated enhanced , constitutive and *stimulated* [ERK] activation . Positive_regulation EPHB2 LPA 23942151 2840840 *induced* phosphorylation of [ERK] and p38 MAP kinase in R182 cells and pretreatment of cells with the MEK-ERK pathway inhibitor U0126 , but not the p38 MAPK inhibitor SB202190 , resulted in abrogation of LPA induced cell migration . Positive_regulation EPHB2 LPA 8947493 400539 The EC50 for *stimulated* [ERK] activation after 10 min , the time of peak response , was 2 orders of magnitude to the left of that for the sustained response after 3 h or that for DNA synthesis after 22 h , with the result that non-mitogenic doses stimulated a maximal peak response but no second phase . Positive_regulation EPHB2 LPA 9148952 430035 Inhibition of *stimulated* MEK and [ERK] activation with PD98059 and pertussis toxin , a selective inhibitor of Gi-protein coupled signaling pathways , reduced LPA stimulated MKP-1 expression by only 50 % , suggesting the presence of additional MEK- and ERK independent pathways for MKP-1 expression . Positive_regulation EPHB2 LPXN 17640867 1787653 The overexpression of in mouse A20 B lymphoma cells *led* to the suppression of BCR induced activation of JNK , p38 MAPK , and , to a lesser extent , Akt , but not [ERK] and NFkappaB , suggesting that LPXN can selectively repress BCR signaling . Positive_regulation EPHB2 LRP1 10591631 654635 By regulating the uPA/uPAR system , may also *regulate* [ERK] activation , cellular migration , and invasion . Positive_regulation EPHB2 LRP1 20220145 2249445 Importantly , the results revealed that expression is *necessary* for PDGF mediated activation of [ERK] . Positive_regulation EPHB2 LRP1 21610072 2454244 The simultaneous stimulation of a receptor tyrosine kinase by its cognate ligand and of ( by lactoferrin or LDL ) *resulted* in sustained activation of [ERK] , which was redirected to the cytoplasm . Positive_regulation EPHB2 LRP10 10591631 654632 By regulating the uPA/uPAR system , may also *regulate* [ERK] activation , cellular migration , and invasion . Positive_regulation EPHB2 LRP11 10591631 654633 By regulating the uPA/uPAR system , may also *regulate* [ERK] activation , cellular migration , and invasion . Positive_regulation EPHB2 LRP12 10591631 654634 By regulating the uPA/uPAR system , may also *regulate* [ERK] activation , cellular migration , and invasion . Positive_regulation EPHB2 LRP2 10591631 654636 By regulating the uPA/uPAR system , may also *regulate* [ERK] activation , cellular migration , and invasion . Positive_regulation EPHB2 LRP3 10591631 654637 By regulating the uPA/uPAR system , may also *regulate* [ERK] activation , cellular migration , and invasion . Positive_regulation EPHB2 LRP4 10591631 654638 By regulating the uPA/uPAR system , may also *regulate* [ERK] activation , cellular migration , and invasion . Positive_regulation EPHB2 LRP5 10591631 654639 By regulating the uPA/uPAR system , may also *regulate* [ERK] activation , cellular migration , and invasion . Positive_regulation EPHB2 LRP6 10591631 654640 By regulating the uPA/uPAR system , may also *regulate* [ERK] activation , cellular migration , and invasion . Positive_regulation EPHB2 LRP8 10591631 654641 By regulating the uPA/uPAR system , may also *regulate* [ERK] activation , cellular migration , and invasion . Positive_regulation EPHB2 LRPAP1 12904304 1150329 Preventing activation *had* no effect on BCR induced activation of [ERK] . Positive_regulation EPHB2 LRPPRC 11457894 838341 Mitogenic hyperresponsiveness of synovial cells to the LIF/IL-6 family of cyto-kines was caused by sustained mediated [SHP-2/ras/Erk] *activation* due to impaired STAT mediated induction of suppressor of cytokine signaling (SOCS) proteins which normally limits gp130 signaling . Positive_regulation EPHB2 LRPPRC 12010564 941218 Synovial cells from this mouse exhibited mitogenic hyper-responsiveness to cytokines of the LIF/IL-6 family , a phenomenon that was caused by sustained mediated [SHP-2/Ras/Erk] *activation* due to a defect in the induction of SOCS-1 ( suppressor of cytokine signaling-1 ; also known as SSI or JAB ) . Positive_regulation EPHB2 LRPPRC 14749363 1204485 Collectively , these results provide a functional and causal correlation between *dependent* [ERK] MAP kinase signaling and c-fms gene activation , a finding that provides a potential mechanism underlying the inhibition of M-CSF dependent macrophage development by IL-6 family cytokines in mice . Positive_regulation EPHB2 LRPPRC 15525763 1329486 Inhibition of the cytokine receptor gp130 using neutralizing antibodies reveals that is *required* for both CNTF induced STAT3 and [ERK] phosphorylation . Positive_regulation EPHB2 LRRFIP1 23880186 2821415 induced VSMC proliferation and *increased* phosphorylation of [ERK] . Positive_regulation EPHB2 LTB4R2 15866883 1419118 Characterization of a mouse second leukotriene B4 receptor , mBLT2 : *dependent* [ERK] activation and cell migration of primary mouse keratinocytes . Positive_regulation EPHB2 LYPLA1 16507078 1529456 These results indicated that *activated* [MAPK/ERK] , a signal for proliferation , differentiation and survival , but did not activate the stress signals p38 MAPK and JNK in human dental pulp cells . Positive_regulation EPHB2 MAB21L2 24906020 2941794 Induced expression of wild-type in human embryonic kidney 293 cells *increased* [phospho-ERK] ( pERK1/2 ) signaling . Positive_regulation EPHB2 MAGI3 16904289 1672817 *regulates* LPA induced activation of [Erk] and RhoA . Positive_regulation EPHB2 MAGI3 16904289 1672830 In contrast , silencing of expression by siRNA drastically *inhibited* LPA induced [Erk] activation , suggesting that the lack of an effect by overexpression was due to the high endogenous MAGI-3 level in these cells . Positive_regulation EPHB2 MAGI3 20353789 2260866 These data suggest that *regulates* beta2AR mediated [ERK] activation through the physical interaction between beta2AR and MAGI-3 . Positive_regulation EPHB2 MAOB 10777699 686940 These results show that *induces* [MAPK/ERK] activation and cell mitogenesis through H ( 2 ) O ( 2 ) production . Positive_regulation EPHB2 MAP2K1 10207078 606735 Nevertheless , *activation* of [ERK] by transient transfection of constitutively active mutant enhanced endogenous topoisomerase II activity by fourfold . Positive_regulation EPHB2 MAP2K1 10383890 624667 The inhibitor , PD 098059 *inhibited* EGF stimulated proliferation and [ERK] activity in a parallel , dose dependent manner showing that ERK activation is at least permissive for the proliferative response to EGF . Positive_regulation EPHB2 MAP2K1 10402467 628938 Ras and were *necessary* and sufficient for uPA induced [ERK] activation and stimulation of cellular migration , as demonstrated in experiments with dominant negative and constitutively active mutants of these signaling proteins . Positive_regulation EPHB2 MAP2K1 10523856 653792 The inhibitor PD 098059 , as well as the PKC inhibitors , completely *blocked* TPA mediated [ERK] activation . Positive_regulation EPHB2 MAP2K1 10688043 669954 Inhibition of EGF- and LPA- induced [ERK] activation with the EGF receptor inhibitor , AG1478 , or the inhibitor , PD98059 , *attenuated* their proliferative effects . Positive_regulation EPHB2 MAP2K1 10700616 672422 We have therefore hypothesized that [ERK] *activation* through is required for optimal induction of neurite growth by these proteins . Positive_regulation EPHB2 MAP2K1 10783161 688170 Sur-8 expression enhances Ras- or EGF induced Raf and ERK activation but has no effect on [ERK] activation *induced* by active Raf or . Positive_regulation EPHB2 MAP2K1 10801894 708026 However , activation is *required* for ONOO ( - ) -induced [ERK] activation in myofibroblasts . Positive_regulation EPHB2 MAP2K1 10888263 710240 However , PD098059 mediated inhibition of *dependent* stimulation of [ERK] did not alter the hypertrophic response of either agonist . Positive_regulation EPHB2 MAP2K1 10960064 726346 The ( mitogen activated ERK kinase ) inhibitor , PD 98059 ( 30 microM ) , *inhibited* both [ERK] phosphorylation and activity , and either prevented ( thrombin 0.3 and 3 u ml(-1) , bFGF 300 pM ) or attenuated ( bFGF 3 nM ) DNA synthesis . Positive_regulation EPHB2 MAP2K1 10965502 727987 17 beta-oestradiol increased B-Raf activity and *dependent* [ERK] phosphorylation in explants of wild-type and ERKO cerebral cortex . Positive_regulation EPHB2 MAP2K1 10980611 731550 MEK inhibitor U0126 blocked the induction , while activated transfected into a rat mammary adenocarcinoma cell line *induced* a sustained activation of [ERK] and up-regulated SMC/Muc4 expression . Positive_regulation EPHB2 MAP2K1 10996792 733906 As in proliferating cells , [ERK] activation during G0 *required* the MAPkinase kinase and was partially dependent on cell adhesion . Positive_regulation EPHB2 MAP2K1 11005808 752390 A inhibitor , PD98059 , *inhibited* heat shock [ERK] MAPK activation by > 75 % . Positive_regulation EPHB2 MAP2K1 11050045 743307 Moreover , the [MAPK/ERK] activation by HCV core protein was blocked in the *presence* of the specific inhibitor , PD98059 . Positive_regulation EPHB2 MAP2K1 11311983 805178 This provides evidence for a novel pathway linking striatal kainate receptors to [ERK] *activation* via PI3 kinase and . Positive_regulation EPHB2 MAP2K1 11359871 816498 6-OHDA elicited ERK phosphorylation was blocked by PD98059 , an inhibitor of the upstream ( MEK ) that phosphorylates and *activates* [ERK] . Positive_regulation EPHB2 MAP2K1 11413312 828898 The inhibitors PD98059 and U0126 *blocked* [Erk] activation and release of IL-8 following infection with Ad7 . Positive_regulation EPHB2 MAP2K1 11418608 843264 VPA induced *activation* of [ERK] was blocked by the mitogen activated protein kinase/ERK kinase inhibitor PD098059 and dominant negative Ras and Raf mutants but not by dominant negative stress activated protein kinase/ERK kinase and 6 mutants . Positive_regulation EPHB2 MAP2K1 11461971 839121 TPA dependent [ERK] phosphorylation was also *blocked* by the inhibitors PD098059 or U0126 . Positive_regulation EPHB2 MAP2K1 11517300 851410 We conclude that glucagon induced and ERK1/2 activation is mediated by PKA and that an increase in intracellular calcium concentration is *required* for maximal [ERK] activation . Positive_regulation EPHB2 MAP2K1 11546664 856568 The mitogen activated protein kinase (MAPK) kinase ( ) inhibitors , PD-98059 and U-0126 , *blocked* IL-1 alpha induced [ERK] activation and partially attenuated cPLA(2)alpha phosphorylation and PGI ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation EPHB2 MAP2K1 11564685 863258 The specific Mek inhibitor , PD98059 , blocked the activation of the Erks by ACTH and basic fibroblast growth factor , indicating that is the upstream *activator* of [Erk] . Positive_regulation EPHB2 MAP2K1 11641250 872076 Stimulation of [Erk] activity was *due* to activation of Ras , Raf-1 , and ( MAPK kinase ) . Positive_regulation EPHB2 MAP2K1 11673351 872736 IGF-I-stimulation was followed by a PI3K dependent phosphorylation of AKT and BAD and an *dependent* phosphorylation of extracellular signal regulated kinase ( [ERK] ) 1 and ERK2 . Positive_regulation EPHB2 MAP2K1 11683901 875696 Naloxone effectively blocked these actions of morphine , whereas a selective inhibitor , PD98059 , *inhibited* the morphine induced increase in the phosphorylation of [ERK] and CREB , and the expression of CGRP and SP . Positive_regulation EPHB2 MAP2K1 11804669 903323 PD 98059 , a inhibitor , and glutathione , an anti-thiol-oxidant , not only *blocked* Cpd 5-induced [ERK] phosphorylation , but also antagonized the activation of CPP-32 , the altered Bcl-2/Bax expression , and DNA fragmentation . Positive_regulation EPHB2 MAP2K1 11812003 907188 The inhibitors , U0126 and PD-98059 , dose-dependently *inhibited* the [ERK] activity stimulated by EGF . Positive_regulation EPHB2 MAP2K1 11841924 912276 PMA also phosphorylated MEK and [ERK] , and PMA induced GATA-4 phosphorylation was *blocked* by an inhibitor , PD98059 , suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway . Positive_regulation EPHB2 MAP2K1 12055096 951679 The inhibitors PD-98059 and U-0126 *blocked* [ERK] activation mediated by diazoxide . Positive_regulation EPHB2 MAP2K1 12070086 955768 Addition of inhibitor in the culture medium *prevented* [ERK] activation and metamorphosis . Positive_regulation EPHB2 MAP2K1 12364324 1019134 GLP1 stimulated activation of [Erk] is *blocked* by inhibitors of , but GLP1 does not induce the activation of A-Raf , B-Raf , C-Raf , or Ras . Positive_regulation EPHB2 MAP2K1 12493768 1056680 Consistent with this premise , FSH stimulated [ERK] activation is *inhibited* by the cell-permeable protein kinase A-specific inhibitor peptide Myr-PKI as well as by inhibitors of , Src , a Ca ( 2+ ) channel blocker , and chelation of extracellular Ca ( 2+ ) . Positive_regulation EPHB2 MAP2K1 12506070 1038321 A specific inhibitor of *blocked* the TNFalpha induction of the MMPs and TIMPs and the phosphorylation of [Erk] . Positive_regulation EPHB2 MAP2K1 12514175 1063801 Low K ( + ) *induced* delayed and persistent [ERK] activation , which was blocked by inhibitors or GDF-15 . Positive_regulation EPHB2 MAP2K1 12554784 1057067 The mutant , which *activates* [ERK] , markedly down-regulated expression of the insulin receptor (IR) and its major substrates , IRS-1 and IRS-2 , mRNA and protein , and in turn reduced tyrosine phosphorylation of IR as well as IRS-1 and IRS-2 and their associated phosphatidyl inositol 3-kinase (PI3K) activity . Positive_regulation EPHB2 MAP2K1 12588763 1059632 inhibitors U0126 and PD98059 *blocked* both [ERK] activation and the increase in TF mRNA . Positive_regulation EPHB2 MAP2K1 12657694 1073284 [ERK] activation was *blocked* by inhibiting , the upstream activator of ERK . Positive_regulation EPHB2 MAP2K1 12664642 1030349 Inhibition of ( proximal activator of Erk ) also *blocked* stimulation of [Erk] and neutrophil aggregation by FMLP and arachidonic acid . Positive_regulation EPHB2 MAP2K1 12675684 1076697 In contrast , the *activation* of [ERK] by constitutively active forms of was not inhibited , suggesting that the actions of SptP were mediated by Raf-1 . Positive_regulation EPHB2 MAP2K1 12686598 1078123 In unstimulated cells , tropomyosin-1 was found diffuse in the cells , whereas it quickly colocalized with actin and stress fibers upon *stimulation* of [ERK] by H ( 2 ) O ( 2 ) or by expression of ( CA ) . Positive_regulation EPHB2 MAP2K1 12706116 1082482 In PC12 cells , NGF and EGF induce a rapid translocation of [GFP-Erk] that *requires* Ras and . Positive_regulation EPHB2 MAP2K1 12736249 1107186 We observed that growth stimulation was associated with stimulation of ERK1/2 phosphorylation (ERK-P) , and both growth and [ERK-P] could be *blocked* by the inhibitor ( U0126 , 100 nm ) . Positive_regulation EPHB2 MAP2K1 12738796 1107263 Surprisingly , this induction of phosphorylation does not *result* in [ERK] activation in vivo . Positive_regulation EPHB2 MAP2K1 12758056 1090981 Inhibition of *induced* [ERK] phosphorylation had no effect on adipogenesis but prevented this TCDD suppression . Positive_regulation EPHB2 MAP2K1 12791686 1120001 Furthermore , inhibition of by pretreatment of NRVM with two structurally distinct inhibitors , PD98059 ( 30 microM ) or UO126 ( 3 microM ) , *inhibited* the activation of [ERK] and p90RSK and abolished the stimulation of NHE activity by sustained ( 3 min ) intracellular acidosis . Positive_regulation EPHB2 MAP2K1 12832008 1105560 inhibitor ( PD98059 ) *suppressed* lead induced [ERK] and p90RSK activation . Positive_regulation EPHB2 MAP2K1 12850584 1109562 Abeta induced [ERK] phosphorylation was completely *blocked* by the inhibitors , while Abeta induced promotion of extracellular L-glutamate clearance was enhanced by the presence of the MEK inhibitors . Positive_regulation EPHB2 MAP2K1 14514659 1185724 A low level ( 2 micro M ) of arsenite stimulated extracellular signal regulated kinase ( ERK ) signaling pathway and enhanced cell proliferation , and this arsenite induced [ERK] activity was *blocked* by inhibitor , PD98059 . Positive_regulation EPHB2 MAP2K1 14517212 1164973 The inhibitors PD 98059 and U0126 *blocked* [ERK] phosphorylation , as did the adenylate cyclase activator forskolin . Positive_regulation EPHB2 MAP2K1 14555984 1153211 In androgen depleted condition , PD98059 , an inhibitor , could efficiently *block* not only the activation of [ERK] , but also the acquisition of the NE-like morphology and the elevation of NSE in C-33 LNCaP cells . Positive_regulation EPHB2 MAP2K1 14563359 1154805 Experiments based on inhibitors of specific signaling pathways , such as manumycin A , toxin A , U0126 , PD98059 and wortmannin revealed that Ras , and PI-3K are *involved* in the activation of [ERK] . Positive_regulation EPHB2 MAP2K1 14612947 1163436 Inhibition of by its specific inhibitor , PD98059 substantially *inhibited* [Erk] activation . Positive_regulation EPHB2 MAP2K1 14688282 1211508 However , PD98059 , a specific inhibitor of ( MEK1 ) , *inhibited* [ERK] activation by TGF-beta(1) , and consequently attenuated TGF-beta(1) enhancement of its own mRNA expression in PSCs . Positive_regulation EPHB2 MAP2K1 14719071 1197686 In cisplatin-resistant UM-SCC-23 in culture , which we have established , the protein levels of Ras , Raf-1 and were drastically elevated compared to parent UM-SCC-23 , and [ERK] and Akt signals were constitutively *activated* . Positive_regulation EPHB2 MAP2K1 14985098 1214792 Both EGF receptor kinase inhibitor AG1478 and inhibitor PD98059 *attenuated* [ERK] activation and DNA synthesis enhanced by Ang II . Positive_regulation EPHB2 MAP2K1 15159408 1273319 Use of U0126 revealed that palytoxin *requires* the ERK kinase to stimulate [ERK] activity , although palytoxin did not activate MEK . Positive_regulation EPHB2 MAP2K1 15174091 1254264 Conversely , treatment with U0126 , a potent inhibitor of mediated [ERK] *activation* , prevented FAK phosphorylation at Ser-910 induced by PDGF but did not interfere with PDGF induced FAK phosphorylation at Tyr-397 . Positive_regulation EPHB2 MAP2K1 15304546 1322379 Furthermore , *activation* of [ERK/MAPK] by the coexpression of constitutively active predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation EPHB2 MAP2K1 15342384 1291922 Both and Mek2 *triggered* [ERK] phosphorylation . Positive_regulation EPHB2 MAP2K1 15496479 1359577 Inhibition of *inhibited* basal as well as EGF induced [ERK] activation and migration . Positive_regulation EPHB2 MAP2K1 15537634 1360470 [ERK] activation was *prevented* by inhibitors that had no effect on PYK2 . Positive_regulation EPHB2 MAP2K1 15607817 1357025 Furthermore , U0126 and LY294002 , which respectively inhibit *induced* [ERK] phosphorylation and PI3 kinase mediated Akt phosphorylation had distinct effects on C3a induced responses . Positive_regulation EPHB2 MAP2K1 15652235 1364130 PD98059 , a inhibitor , and BAY 11-8702 , an I kappa B-alpha inhibitor , *reduced* [ERK] and NF-kappa B cascade activation , respectively , with little effect on PKC phosphorylation . Positive_regulation EPHB2 MAP2K1 15674440 1350823 [ERK] phosphorylation was *reduced* by a inhibitor , PD98059 . Positive_regulation EPHB2 MAP2K1 15691837 1388546 In its central portion *activates* [ERK] , leading to increased collagen expression . Positive_regulation EPHB2 MAP2K1 15749869 1379687 We found that prior stimulation of primary murine B cells with CD40L markedly enhanced the level of ERK and JNK ( but not p38 MAPK ) phosphorylation produced by subsequently added anti-Ig Ab , and much , but not all , of this enhancement was independent of PI3K and phospholipase C . CD40L treatment similarly enhanced BCR induced MAPK kinase ( MEK ) phosphorylation , and was *required* for enhancement of [ERK] . Positive_regulation EPHB2 MAP2K1 15750341 1379869 These findings indicate that [ERK] phosphorylation in response to glycated LDL *involves* the activation of PKC , PLC , and , but is independent of intracellular Ca2+ . Positive_regulation EPHB2 MAP2K1 15753041 1380052 Inhibition of ERK signaling by the MEK ( MAPK/ERK kinase ) inhibitor U0126 blocks bidirectional melanosome transport along microtubules , and *stimulation* of [ERK] by constitutively active stimulates transport . Positive_regulation EPHB2 MAP2K1 15801908 1432339 The ( MAPK/ERK kinase ) inhibitors PD98059 and U0126 *blocked* IGF-I stimulated [ERK] phosphorylation but did not block the phosphorylation of Akt and did not decrease proteoglycan synthesis . Positive_regulation EPHB2 MAP2K1 15805288 1390983 Expression of constitutively active *caused* an increase of [ERK] activity and inhibited STAT3 ( ( Tyr705 ) ) phosphorylation . Positive_regulation EPHB2 MAP2K1 15843032 1398305 Treatment of myoblasts with LIF induced phosphorylation of [ERK] , and the LIF induced inhibitory effect on myogenesis was *blocked* by pretreatment with U0126 , a specific inhibitor , and transient transfection with dominant negative ( DN ) -MEK1 . Positive_regulation EPHB2 MAP2K1 15843535 1398462 As in the classical pathway , BCR induced [ERK] activation in the new , PI3K independent pathway *required* and was reflected in c-Raf . Positive_regulation EPHB2 MAP2K1 15855657 1439585 Activation of ERK was attenuated by drugs that disassemble the actin cytoskeleton ( cytochalasin D , latrunculin B ) , and these compounds interfered with the *activation* of [ERK] by ( MEK ) . Positive_regulation EPHB2 MAP2K1 16189274 1507730 In MET positive DLBCL cells , HGF induces *dependent* activation of [ERK] and PI3K dependent phosphorylation of PKB , GSK3 , and FOXO3a . Positive_regulation EPHB2 MAP2K1 16210650 1464506 [ERK] phosphorylation and chemokine production in response to LPA *require* IL-4 dependent up-regulation of expression by a pathway involving PI3K . Positive_regulation EPHB2 MAP2K1 16360949 1504579 The phospho-ERK and phospho-MEK profiles were similar , suggesting that [ERK] phosphorylation is *regulated* by . Positive_regulation EPHB2 MAP2K1 16413539 1514343 Pretreatment of HSFs with 2',4',7-THF inhibited UV-induced MMP-1 expression in a dose dependent manner , and also *inhibited* the UV-induced activations of [ERK] and JNK by inhibiting and SEK1 activation , respectively . Positive_regulation EPHB2 MAP2K1 16877565 1638796 However , inhibitors of Raf-1 and or a dominant negative ERK mutant *blocked* FKN induced [ERK] , but not Akt and eNOS , phosphorylation . Positive_regulation EPHB2 MAP2K1 16983658 1633615 In parallel , farnesyltransferase and inhibitors *blocked* [ERK] phosphorylation and neuroprotective effect of NAC . Positive_regulation EPHB2 MAP2K1 17108079 1650992 The 50-kDa [ERK] was shown to be stimulated by Con A , and inhibition of *down-regulated* the 50-kDa ERK as was shown for ERK1 ,2 . Positive_regulation EPHB2 MAP2K1 17130674 1661366 PD98059 , a ( mitogen activated protein kinase kinase ) inhibitor , and BAPTA-AM [ O , O'-bis ( 2-aminophenyl ) ethyleneglycol-N , N,N ' , N'-tetraacetic acid , tetraacetoxymethyl ester ] , an intracellular Ca ( 2+ ) chelator , *reduced* UTP induced [ERK] phosphorylation and IL-6 mRNA expression . Positive_regulation EPHB2 MAP2K1 17182785 1662663 Specifically , inhibition of GSK-3beta led to increased [ERK] phosphorylation , and inhibition of completely *blocked* the effects of GSK-3beta inhibition on dendrite initiation and growth . Positive_regulation EPHB2 MAP2K1 17189385 1662767 In addition , inhibitor ( PD98059 ) *reduced* the interaction between p65 and [ERK] . Positive_regulation EPHB2 MAP2K1 17337598 1765817 A pharmacological inhibitor of activity *inhibits* LPA stimulated WT Hic-5 cell migration and [ERK] phosphorylation , suggesting Hic-5 enhances migration via MEK activation of ERK . Positive_regulation EPHB2 MAP2K1 17379261 1720775 FTY720P augmented [ERK] phosphorylation in cortical cultures prepared from embryonic day 18 rat brains and was *blocked* by an inhibitor or by pertussis toxin . Positive_regulation EPHB2 MAP2K1 17526574 1784066 , once phosphorylated by Raf , *triggers* [Erk] phosphorylation , which in turn induces dissociation of Raf-inaccessible Mek-Erk heterodimers , and thus further amplifies Mek phosphorylation . Positive_regulation EPHB2 MAP2K1 17879163 1818402 Treatment with V+H- decreased the phosphorylation of extracellular signal regulated kinase ( ERK ) 1 and 2 , and direct *activation* of [ERK] by constitutively active , an ERK kinase , increased ERK1 and ERK2 phosphorylation and inhibited the increase in apoptosis induced by V+H- . Positive_regulation EPHB2 MAP2K1 18068691 1853768 This mechanism was found to be specific to etorphine , as activation of [ERK] by the micro-opioid receptor ( MOR ) agonist DAMGO ( [ D-Ala ( 2 ) , N-Me-Phe ( 4 ) , Gly ( 5 ) -ol ] enkephalin ) was *mediated* by in these cells , suggesting that etorphine and DAMGO activate distinct , ligand-specific , conformations of MOR . Positive_regulation EPHB2 MAP2K1 18401006 1925750 CyaA enhanced LPS induced phosphorylation of p38 MAPK and [ERK] in DC , and inhibitors of p38 MAPK , , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation EPHB2 MAP2K1 18443432 1944601 Kaempferol was demonstrated to *induce* sustained [ERK] activation concomitantly with and ELK1 activation , and this kaempferol induced apoptosis was suppressed by treatment with PD98059 , the overexpression of a kinase-inactive ERK mutant , or ERK siRNA . Positive_regulation EPHB2 MAP2K1 18454176 1951540 Moreover , GATA-6 was phosphorylated at serine residues by *activated* [ERK] , which increased GATA-6 DNA binding , correlating with suppression of the Nox1 promoter activity by an MEK inhibitor PD98059 . Positive_regulation EPHB2 MAP2K1 18463290 1910047 Using 293A cells and in vitro experiments , we detail the formation of a ternary complex of [MEK/ERK/hBVR] , *activation* of and ERK1/2 kinase activities by hBVR , and phosphorylation of hBVR by ERK1/2 . Positive_regulation EPHB2 MAP2K1 18563700 1940822 Artificial [Erk] *activation* by expression of constitutively active and B-Raf failed to block ephrin-A5 effects on growth cones , and inhibitors of the Erk pathway also failed to inhibit collapse by ephrin-A5 . Positive_regulation EPHB2 MAP2K1 18632602 1937013 A selective inhibitor , AZD6244 , *inhibits* mutant induced [ERK] activity in 293T cells and growth of mutant bearing Ba/F3 cells . Positive_regulation EPHB2 MAP2K1 18656513 1972850 was *required* for phosphorylation of [ERK] and CREB , but not Akt , whereas G ( 0 ) /G ( i ) -proteins were necessary for phosphorylation of Akt and CREB , and cGMP was necessary for Akt phosphorylation . Positive_regulation EPHB2 MAP2K1 18695640 1973868 ROCK inhibition also reduced 5-HT stimulated proliferation by suppressing *stimulated* [ERK] phosphorylation . Positive_regulation EPHB2 MAP2K1 18711316 2005998 Moreover , pretreatment with DIDS ( Cl- channel blockers ) but not LY294002 ( PI3K inhibitors ) completely abolished the LDL induced upregulation of Egr-1 to the same extent as PD98059 ( inhibitors to *inhibit* [Erk] ) , as judged by Western blot and luciferase reporter assays . Positive_regulation EPHB2 MAP2K1 18762250 1975630 Additionally , EGFR undergoes *dependent* [ERK] consensus site phosphorylation in response to EGF or cytokines such as growth hormone (GH) and prolactin (PRL) . Positive_regulation EPHB2 MAP2K1 18771726 1980331 We demonstrated here , that PTPIP51 could regulate ERK activity on Raf level , since inhibitor and dominant negative Raf-1 but not Ras could *inhibit* the [ERK] activation induced by PTPIP51 . Positive_regulation EPHB2 MAP2K1 19098317 2047659 PI3K inhibitor ( Ly294002 ) significantly decreased pAkt activity and HIF-1alpha and VEGF expression in vivo and in vitro , whereas inhibitor ( PD98059 ) *reduced* [ERK] phosphorylation and the expression of VEGF but had no effect on HIF-1alpha . Positive_regulation EPHB2 MAP2K1 19135136 2037662 JNK inhibition induces a compensatory effect and leads to [ERK] *activation* via , resulting in an activation of the survival pathway- ( MEK1/ERK ) as a consequence of the death pathway- ( JNK ) inhibition . Positive_regulation EPHB2 MAP2K1 19176641 2061147 U-0126 , the ( MAPK kinase ) inhibitors *blocked* [ERK] activation and cell proliferation induced by diazoxide . Positive_regulation EPHB2 MAP2K1 19219045 2044449 Thus , in disagreement with the current perception of the pathway , the *role* of and Mek2 in growth factor induced [Erk] phosphorylation is not interchangeable . Positive_regulation EPHB2 MAP2K1 19241161 2086555 Furthermore , we also demonstrated here that Zn2+ stimulates the phosphorylation of [ERK] and that the pathway inhibitor , U0126 , *suppressed* Zn2+ induced PUMA expression . Positive_regulation EPHB2 MAP2K1 19299917 2064165 A chemical inhibitor of or PI3K *reduced* phosphorylation of [ERK] or Akt , respectively , and also inhibited CSE mediated MMP-9 induction . Positive_regulation EPHB2 MAP2K1 19319189 2052418 multiprotein complex to *promote* sustained [ERK] activation and regulate H-Ras dependent neuritogenesis . Positive_regulation EPHB2 MAP2K1 19411256 2089712 Additionally , constitutive *activation* of [ERK] by constitutively activated rescues the KLF5 depletion induced MKP-1 down-regulation . Positive_regulation EPHB2 MAP2K1 19703440 2158078 Furthermore , [ERK] activation and angiogenic sprouting in response to NMB are significantly *blocked* by the inhibitor . Positive_regulation EPHB2 MAP2K1 19887597 2299458 aPKC Thr410 phosphorylation and activation also required *dependent* [ERK] ; Positive_regulation EPHB2 MAP2K1 20526801 2320139 Furthermore , we also demonstrate that either chemical inhibition of ( U0126 ) or stable downregulation of PDGFRß by shRNA similarly *results* in the loss of PDGF induced [ERK] phosphorylation and abolishes Rac1/Pak1 activation and cell migration in response to PDGF . Positive_regulation EPHB2 MAP2K1 20542106 2301952 Activation of these pathways by ATP seemed to be independent , since LY294002 and U0126 , inhibitors of PI3K and , did not *block* the activation of [ERK] and AKT , respectively , although each compound blocked its respective target . Positive_regulation EPHB2 MAP2K1 20668238 2305302 inhibitors *inhibit* [ERK] phosphorylation in all normal and tumor cells , whereas PLX4032 inhibits ERK signaling only in tumor cells expressing BRAF ( V600E ) . Positive_regulation EPHB2 MAP2K1 20668435 2317103 In addition , DHA caused AKT and [ERK] activation in a time dependent manner , and the DHA induced HO-1 upregulation could be *attenuated* by PI-3 kinase/AKT and inhibitors . Positive_regulation EPHB2 MAP2K1 21088259 2389771 These cells displayed high levels of ERK activation , that is , at least in part , independent of the conventional RAF/MEK/ERK pathway , as MEK activation was low and inhibition of did not significantly *block* activation of [ERK] . Positive_regulation EPHB2 MAP2K1 21106560 2395795 Experiments carried out with pharmacological inhibitors show that *dependent* [ERK] and phosphatidylinositol 3-kinase dependent AKT pathways are positive regulators of the lectin- and insulin mediated adipogenic differentiation , while stress activated kinase/c-jun N-terminal kinase pathway acts as a negative one . Positive_regulation EPHB2 MAP2K1 21336309 2399442 Expression of un-SUMOylatable *enhanced* [ERK] activation , cell differentiation , proliferation and malignant transformation by oncogenic ErbB2 or Raf , but not by active Ras . Positive_regulation EPHB2 MAP2K1 21665194 2446300 inhibitors and alpha7-nicotinic acetylcholine receptor ( a7nAChR ) antagonist *blocked* the neurite outgrowth and the activation of [ERK] induced by B12H . Positive_regulation EPHB2 MAP2K1 21705076 2460555 An immediate increase in [ERK] was observed in cells cultured in the 1/4 extract and such osteogenic differentiation of hASCs promoted by released ions could be *blocked* by inhibitor , PD98059 . Positive_regulation EPHB2 MAP2K1 21914493 2506756 Inhibition of GSK-3ß by the kinase-inactive GSK-3ß mutant or *activation* of [ERK] by the active mutant abrogated glucocorticoid induced inhibition of osteoblast differentiation . Positive_regulation EPHB2 MAP2K1 22085529 2534360 Mitogen activated protein kinase kinase ( inhibitor , UO126 and [ERK] *inhibitor* II , FR180204 blocked the Elk-1 phosphorylation and activation . Positive_regulation EPHB2 MAP2K1 22087839 2514172 Therefore , inhibition of mediated [ERK] *activation* is very appealing in cancer therapy . Positive_regulation EPHB2 MAP2K1 22087839 2514179 Inhibition of mediated [ERK] *activation* , therefore , compromises checkpoint activation . Positive_regulation EPHB2 MAP2K1 22278923 2551569 By contrast , in human embryos , inhibition of MEK did not significantly alter epiblast or hypoblast precursor numbers despite the ability of the inhibitor to potently *inhibit* [ERK] phosphorylation in human ES cells . Positive_regulation EPHB2 MAP2K1 22328534 2642851 PD98059 , inhibitor , or U0126 , [ERK] *inhibitor* , reduced SNU668 cell migration accompanying an increase in p-GSK-3a , ß-catenin and E-cadherin . Positive_regulation EPHB2 MAP2K1 22556409 2614114 [ERK] activation was *prevented* by inhibitors and was associated with concurrent stimulation of RAF kinase activity but not RAS activation . Positive_regulation EPHB2 MAP2K1 22674427 2715287 In addition , [ERK] *activation* by over-expression of constitutively active strongly increased GATA-4 phosphorylation and subsequently enhanced its acetylation in P19 cells . Positive_regulation EPHB2 MAP2K1 22740332 2715438 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Positive_regulation EPHB2 MAP2K1 22785235 2691763 TRH induced CRE promoter was inhibited by mitogen activated protein [kinase/ERK] kinase ( MEK ) inhibitor and was *increased* by overexpression of . Positive_regulation EPHB2 MAP2K1 22892241 2666327 However , unlike ( V600E ) Braf , pathway activation was mediated by both Craf and Braf , and ATP-competitive RAF inhibitors *induced* paradoxical [Mek/Erk] pathway activation . Positive_regulation EPHB2 MAP2K1 22906417 2678029 Furthermore , post-EMT cells exhibited decreased basal Raf and [Erk] phosphorylation , and in comparison to pre-EMT cells , their proliferation was poorly *inhibited* by a inhibitor . Positive_regulation EPHB2 MAP2K1 22915752 2697496 Overexpression of an active form of *resulted* in [ERK] activation and downregulation of BRCA1 , whereas the MEK inhibitor AZD6244 increased BRCA1/2 expression and reversed the effects of MEK1 . Positive_regulation EPHB2 MAP2K1 23098854 2717295 Conversely , enforcing [ERK] *activation* by reduced ETOP initiated DNA-PKcs activation . Positive_regulation EPHB2 MAP2K1 23102728 2729189 inhibitors , either AZD6244 or CI1040 , *inhibited* [ERK] phosphorylation and sensitized gefitinib induced cytotoxicity in PC-9/gef cells . Positive_regulation EPHB2 MAP2K1 23210697 2736379 Complete [ERK] *activation* by the kinase requires dual phosphorylation at T and Y within the activation motif TEY . Positive_regulation EPHB2 MAP2K1 23360980 2758730 Consequently , coexpression of wildtype C-Raf and was *sufficient* for full and constitutive activation of [ERK] . Positive_regulation EPHB2 MAP2K1 23499828 2827631 H2S stimulated T cell activation by potentiating *dependent* [ERK] phosphorylation , and thrombospondin-1 inhibited this signaling in a CD47 dependent manner . Positive_regulation EPHB2 MAP2K1 23524336 2777293 A lack of or ability to accumulate tMEK *resulted* in the absence of the feedback inhibition of [ERK] and p90RSK activations . Positive_regulation EPHB2 MAP2K1 23806683 2820632 [ERK] *activation* by the over-expression of constitutively active increased protein levels and enhanced the stability of SIRT2 . Positive_regulation EPHB2 MAP2K1 24530412 2924276 It is noteworthy that a tyrosine kinase receptor inhibitor , K252a , an inhibitor ( U0126 ) , and a PI3Kinase-Akt inhibitor ( LY294002 ) remarkably *attenuated* TrkB , [ERK] , and Akt phosphorylation as well as increase of OPN mRNA expression in the HCEM cells , respectively . Positive_regulation EPHB2 MAP2K1 24746704 2936457 Here , we found that inhibitors *suppress* [ERK] signaling more potently in BRAF ( V600E ) , than in KRAS mutant tumors . Positive_regulation EPHB2 MAP2K1 8226933 235289 *Activation* of extracellular signal regulated kinase ( [ERK] ) or mitogen activated protein kinase by ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation EPHB2 MAP2K1 8552085 347153 Expression of a dominant interfering mutant , in which lysine 97 was replaced with arginine ( MEK/K97R ) , *resulted* in an inhibition of insulin stimulated SOS and [ERK] phosphorylation , whereas expression of a constitutively active MEK mutant , in which serines 218 and 222 were replaced with glutamic acid ( MEK/EE ) , induced basal phosphorylation of both SOS and ERK . Positive_regulation EPHB2 MAP2K1 8898934 393168 expression *led* to constitutive [ERK] activation , which acted synergystically with ionomycin treatment to stimulate cytokine production . Positive_regulation EPHB2 MAP2K1 9124614 424134 is *required* for PDGF induced [ERK] activation and DNA synthesis in tracheal myocytes . Positive_regulation EPHB2 MAP2K1 9124614 424137 PD-98059 ( 10 microM ) inhibited MEK1 and ERK activation , confirming that is *required* for [ERK] activation in bovine tracheal myocytes . Positive_regulation EPHB2 MAP2K1 9124614 424138 We conclude that is *required* for PDGF induced [ERK] activation in bovine tracheal myocytes and that MEK1 and ERKs are required for PDGF induced DNA synthesis in these cells . Positive_regulation EPHB2 MAP2K1 9390997 467672 Furthermore , overexpression of a kinase-inactive mutant *inhibited* phorbol ester stimulation of APP secretion and activation of [ERK] in human embryonic kidney cell lines . Positive_regulation EPHB2 MAP2K1 9442025 482986 Arsenite induced [ERK] activation is *mediated* by Ras , Raf , and but appears to be independent of de novo protein synthesis . Positive_regulation EPHB2 MAP2K1 9687508 522236 Consistently , induced [ERK] *activation* in PC12 cells induces c-Jun expression , while JNK signalling does not . Positive_regulation EPHB2 MAP2K1 9826736 550734 Inhibition of ( proximal activator of Erk ) also *blocked* stimulation of [Erk] and adhesion by formylmethionyl-leucyl-phenylalanineand arachidonic acid . Positive_regulation EPHB2 MAP2K1 9864179 582698 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of [ERK] , but not p38 MAPK , induced by G-CSF , GM-CSF , or TNF . Positive_regulation EPHB2 MAP2K2 10383890 624668 The inhibitor , PD 098059 *inhibited* EGF stimulated proliferation and [ERK] activity in a parallel , dose dependent manner showing that ERK activation is at least permissive for the proliferative response to EGF . Positive_regulation EPHB2 MAP2K2 10402467 628939 Ras and were *necessary* and sufficient for uPA induced [ERK] activation and stimulation of cellular migration , as demonstrated in experiments with dominant negative and constitutively active mutants of these signaling proteins . Positive_regulation EPHB2 MAP2K2 10523856 653793 The inhibitor PD 098059 , as well as the PKC inhibitors , completely *blocked* TPA mediated [ERK] activation . Positive_regulation EPHB2 MAP2K2 10688043 669955 Inhibition of EGF- and LPA- induced [ERK] activation with the EGF receptor inhibitor , AG1478 , or the inhibitor , PD98059 , *attenuated* their proliferative effects . Positive_regulation EPHB2 MAP2K2 10700616 672423 We have therefore hypothesized that [ERK] *activation* through is required for optimal induction of neurite growth by these proteins . Positive_regulation EPHB2 MAP2K2 10783161 688171 Sur-8 expression enhances Ras- or EGF induced Raf and ERK activation but has no effect on [ERK] activation *induced* by active Raf or . Positive_regulation EPHB2 MAP2K2 10888263 710241 However , PD098059 mediated inhibition of *dependent* stimulation of [ERK] did not alter the hypertrophic response of either agonist . Positive_regulation EPHB2 MAP2K2 10965502 727988 17 beta-oestradiol increased B-Raf activity and *dependent* [ERK] phosphorylation in explants of wild-type and ERKO cerebral cortex . Positive_regulation EPHB2 MAP2K2 10996792 733907 As in proliferating cells , [ERK] activation during G0 *required* the MAPkinase kinase and was partially dependent on cell adhesion . Positive_regulation EPHB2 MAP2K2 11005808 752391 A inhibitor , PD98059 , *inhibited* heat shock [ERK] MAPK activation by > 75 % . Positive_regulation EPHB2 MAP2K2 11311983 805179 This provides evidence for a novel pathway linking striatal kainate receptors to [ERK] *activation* via PI3 kinase and . Positive_regulation EPHB2 MAP2K2 11359871 816499 6-OHDA elicited ERK phosphorylation was blocked by PD98059 , an inhibitor of the upstream ( MEK ) that phosphorylates and *activates* [ERK] . Positive_regulation EPHB2 MAP2K2 11413312 828899 The inhibitors PD98059 and U0126 *blocked* [Erk] activation and release of IL-8 following infection with Ad7 . Positive_regulation EPHB2 MAP2K2 11418608 843265 VPA induced *activation* of [ERK] was blocked by the mitogen activated protein kinase/ERK kinase inhibitor PD098059 and dominant negative Ras and Raf mutants but not by dominant negative stress activated protein kinase/ERK kinase and 6 mutants . Positive_regulation EPHB2 MAP2K2 11546664 856569 The mitogen activated protein kinase (MAPK) kinase ( ) inhibitors , PD-98059 and U-0126 , *blocked* IL-1 alpha induced [ERK] activation and partially attenuated cPLA(2)alpha phosphorylation and PGI ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation EPHB2 MAP2K2 11564685 863259 The specific Mek inhibitor , PD98059 , blocked the activation of the Erks by ACTH and basic fibroblast growth factor , indicating that is the upstream *activator* of [Erk] . Positive_regulation EPHB2 MAP2K2 11641250 872077 Stimulation of [Erk] activity was *due* to activation of Ras , Raf-1 , and ( MAPK kinase ) . Positive_regulation EPHB2 MAP2K2 11804669 903324 PD 98059 , a inhibitor , and glutathione , an anti-thiol-oxidant , not only *blocked* Cpd 5-induced [ERK] phosphorylation , but also antagonized the activation of CPP-32 , the altered Bcl-2/Bax expression , and DNA fragmentation . Positive_regulation EPHB2 MAP2K2 11812003 907189 The inhibitors , U0126 and PD-98059 , dose-dependently *inhibited* the [ERK] activity stimulated by EGF . Positive_regulation EPHB2 MAP2K2 11841924 912277 PMA also phosphorylated MEK and [ERK] , and PMA induced GATA-4 phosphorylation was *blocked* by an inhibitor , PD98059 , suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway . Positive_regulation EPHB2 MAP2K2 12055096 951680 The inhibitors PD-98059 and U-0126 *blocked* [ERK] activation mediated by diazoxide . Positive_regulation EPHB2 MAP2K2 12070086 955769 Addition of inhibitor in the culture medium *prevented* [ERK] activation and metamorphosis . Positive_regulation EPHB2 MAP2K2 12364324 1019135 GLP1 stimulated activation of [Erk] is *blocked* by inhibitors of , but GLP1 does not induce the activation of A-Raf , B-Raf , C-Raf , or Ras . Positive_regulation EPHB2 MAP2K2 12493768 1056681 Consistent with this premise , FSH stimulated [ERK] activation is *inhibited* by the cell-permeable protein kinase A-specific inhibitor peptide Myr-PKI as well as by inhibitors of , Src , a Ca ( 2+ ) channel blocker , and chelation of extracellular Ca ( 2+ ) . Positive_regulation EPHB2 MAP2K2 12506070 1038322 A specific inhibitor of *blocked* the TNFalpha induction of the MMPs and TIMPs and the phosphorylation of [Erk] . Positive_regulation EPHB2 MAP2K2 12514175 1063802 Low K ( + ) *induced* delayed and persistent [ERK] activation , which was blocked by inhibitors or GDF-15 . Positive_regulation EPHB2 MAP2K2 12588763 1059633 inhibitors U0126 and PD98059 *blocked* both [ERK] activation and the increase in TF mRNA . Positive_regulation EPHB2 MAP2K2 12657694 1073285 [ERK] activation was *blocked* by inhibiting , the upstream activator of ERK . Positive_regulation EPHB2 MAP2K2 12664642 1030350 Inhibition of ( proximal activator of Erk ) also *blocked* stimulation of [Erk] and neutrophil aggregation by FMLP and arachidonic acid . Positive_regulation EPHB2 MAP2K2 12675684 1076698 In contrast , the *activation* of [ERK] by constitutively active forms of was not inhibited , suggesting that the actions of SptP were mediated by Raf-1 . Positive_regulation EPHB2 MAP2K2 12686598 1078124 In unstimulated cells , tropomyosin-1 was found diffuse in the cells , whereas it quickly colocalized with actin and stress fibers upon *stimulation* of [ERK] by H ( 2 ) O ( 2 ) or by expression of ( CA ) . Positive_regulation EPHB2 MAP2K2 12706116 1082483 In PC12 cells , NGF and EGF induce a rapid translocation of [GFP-Erk] that *requires* Ras and . Positive_regulation EPHB2 MAP2K2 12736249 1107187 We observed that growth stimulation was associated with stimulation of ERK1/2 phosphorylation (ERK-P) , and both growth and [ERK-P] could be *blocked* by the inhibitor ( U0126 , 100 nm ) . Positive_regulation EPHB2 MAP2K2 12738796 1107264 Surprisingly , this induction of phosphorylation does not *result* in [ERK] activation in vivo . Positive_regulation EPHB2 MAP2K2 12758056 1090982 Inhibition of *induced* [ERK] phosphorylation had no effect on adipogenesis but prevented this TCDD suppression . Positive_regulation EPHB2 MAP2K2 12850584 1109563 Abeta induced [ERK] phosphorylation was completely *blocked* by the inhibitors , while Abeta induced promotion of extracellular L-glutamate clearance was enhanced by the presence of the MEK inhibitors . Positive_regulation EPHB2 MAP2K2 14514659 1185725 A low level ( 2 micro M ) of arsenite stimulated extracellular signal regulated kinase ( ERK ) signaling pathway and enhanced cell proliferation , and this arsenite induced [ERK] activity was *blocked* by inhibitor , PD98059 . Positive_regulation EPHB2 MAP2K2 14517212 1164974 The inhibitors PD 98059 and U0126 *blocked* [ERK] phosphorylation , as did the adenylate cyclase activator forskolin . Positive_regulation EPHB2 MAP2K2 14555984 1153212 In androgen depleted condition , PD98059 , an inhibitor , could efficiently *block* not only the activation of [ERK] , but also the acquisition of the NE-like morphology and the elevation of NSE in C-33 LNCaP cells . Positive_regulation EPHB2 MAP2K2 14563359 1154806 Experiments based on inhibitors of specific signaling pathways , such as manumycin A , toxin A , U0126 , PD98059 and wortmannin revealed that Ras , and PI-3K are *involved* in the activation of [ERK] . Positive_regulation EPHB2 MAP2K2 14688282 1211509 However , PD98059 , a specific inhibitor of ( MEK1 ) , *inhibited* [ERK] activation by TGF-beta(1) , and consequently attenuated TGF-beta(1) enhancement of its own mRNA expression in PSCs . Positive_regulation EPHB2 MAP2K2 14719071 1197687 In cisplatin-resistant UM-SCC-23 in culture , which we have established , the protein levels of Ras , Raf-1 and were drastically elevated compared to parent UM-SCC-23 , and [ERK] and Akt signals were constitutively *activated* . Positive_regulation EPHB2 MAP2K2 15159408 1273320 Use of U0126 revealed that palytoxin *requires* the ERK kinase to stimulate [ERK] activity , although palytoxin did not activate MEK . Positive_regulation EPHB2 MAP2K2 15174091 1254265 Conversely , treatment with U0126 , a potent inhibitor of mediated [ERK] *activation* , prevented FAK phosphorylation at Ser-910 induced by PDGF but did not interfere with PDGF induced FAK phosphorylation at Tyr-397 . Positive_regulation EPHB2 MAP2K2 15304546 1322380 Furthermore , *activation* of [ERK/MAPK] by the coexpression of constitutively active predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation EPHB2 MAP2K2 15342384 1291923 Both Mek1 and *triggered* [ERK] phosphorylation . Positive_regulation EPHB2 MAP2K2 15537634 1360471 [ERK] activation was *prevented* by inhibitors that had no effect on PYK2 . Positive_regulation EPHB2 MAP2K2 15607817 1357026 Furthermore , U0126 and LY294002 , which respectively inhibit *induced* [ERK] phosphorylation and PI3 kinase mediated Akt phosphorylation had distinct effects on C3a induced responses . Positive_regulation EPHB2 MAP2K2 15652235 1364131 PD98059 , a inhibitor , and BAY 11-8702 , an I kappa B-alpha inhibitor , *reduced* [ERK] and NF-kappa B cascade activation , respectively , with little effect on PKC phosphorylation . Positive_regulation EPHB2 MAP2K2 15674440 1350824 [ERK] phosphorylation was *reduced* by a inhibitor , PD98059 . Positive_regulation EPHB2 MAP2K2 15691837 1388547 In its central portion *activates* [ERK] , leading to increased collagen expression . Positive_regulation EPHB2 MAP2K2 15749869 1379688 We found that prior stimulation of primary murine B cells with CD40L markedly enhanced the level of ERK and JNK ( but not p38 MAPK ) phosphorylation produced by subsequently added anti-Ig Ab , and much , but not all , of this enhancement was independent of PI3K and phospholipase C . CD40L treatment similarly enhanced BCR induced MAPK kinase ( MEK ) phosphorylation , and was *required* for enhancement of [ERK] . Positive_regulation EPHB2 MAP2K2 15750341 1379870 These findings indicate that [ERK] phosphorylation in response to glycated LDL *involves* the activation of PKC , PLC , and , but is independent of intracellular Ca2+ . Positive_regulation EPHB2 MAP2K2 15801908 1432340 The ( MAPK/ERK kinase ) inhibitors PD98059 and U0126 *blocked* IGF-I stimulated [ERK] phosphorylation but did not block the phosphorylation of Akt and did not decrease proteoglycan synthesis . Positive_regulation EPHB2 MAP2K2 15843032 1398306 Treatment of myoblasts with LIF induced phosphorylation of [ERK] , and the LIF induced inhibitory effect on myogenesis was *blocked* by pretreatment with U0126 , a specific inhibitor , and transient transfection with dominant negative ( DN ) -MEK1 . Positive_regulation EPHB2 MAP2K2 15843535 1398463 As in the classical pathway , BCR induced [ERK] activation in the new , PI3K independent pathway *required* and was reflected in c-Raf . Positive_regulation EPHB2 MAP2K2 15855657 1439586 Activation of ERK was attenuated by drugs that disassemble the actin cytoskeleton ( cytochalasin D , latrunculin B ) , and these compounds interfered with the *activation* of [ERK] by ( MEK ) . Positive_regulation EPHB2 MAP2K2 16189274 1507731 In MET positive DLBCL cells , HGF induces *dependent* activation of [ERK] and PI3K dependent phosphorylation of PKB , GSK3 , and FOXO3a . Positive_regulation EPHB2 MAP2K2 16360949 1504580 The phospho-ERK and phospho-MEK profiles were similar , suggesting that [ERK] phosphorylation is *regulated* by . Positive_regulation EPHB2 MAP2K2 16877565 1638797 However , inhibitors of Raf-1 and or a dominant negative ERK mutant *blocked* FKN induced [ERK] , but not Akt and eNOS , phosphorylation . Positive_regulation EPHB2 MAP2K2 16983658 1633616 In parallel , farnesyltransferase and inhibitors *blocked* [ERK] phosphorylation and neuroprotective effect of NAC . Positive_regulation EPHB2 MAP2K2 17130674 1661367 PD98059 , a ( mitogen activated protein kinase kinase ) inhibitor , and BAPTA-AM [ O , O'-bis ( 2-aminophenyl ) ethyleneglycol-N , N,N ' , N'-tetraacetic acid , tetraacetoxymethyl ester ] , an intracellular Ca ( 2+ ) chelator , *reduced* UTP induced [ERK] phosphorylation and IL-6 mRNA expression . Positive_regulation EPHB2 MAP2K2 17182785 1662664 Specifically , inhibition of GSK-3beta led to increased [ERK] phosphorylation , and inhibition of completely *blocked* the effects of GSK-3beta inhibition on dendrite initiation and growth . Positive_regulation EPHB2 MAP2K2 17189385 1662768 In addition , inhibitor ( PD98059 ) *reduced* the interaction between p65 and [ERK] . Positive_regulation EPHB2 MAP2K2 17337598 1765818 A pharmacological inhibitor of activity *inhibits* LPA stimulated WT Hic-5 cell migration and [ERK] phosphorylation , suggesting Hic-5 enhances migration via MEK activation of ERK . Positive_regulation EPHB2 MAP2K2 17379261 1720776 FTY720P augmented [ERK] phosphorylation in cortical cultures prepared from embryonic day 18 rat brains and was *blocked* by an inhibitor or by pertussis toxin . Positive_regulation EPHB2 MAP2K2 17526574 1784067 , once phosphorylated by Raf , *triggers* [Erk] phosphorylation , which in turn induces dissociation of Raf-inaccessible Mek-Erk heterodimers , and thus further amplifies Mek phosphorylation . Positive_regulation EPHB2 MAP2K2 18068691 1853769 This mechanism was found to be specific to etorphine , as activation of [ERK] by the micro-opioid receptor ( MOR ) agonist DAMGO ( [ D-Ala ( 2 ) , N-Me-Phe ( 4 ) , Gly ( 5 ) -ol ] enkephalin ) was *mediated* by in these cells , suggesting that etorphine and DAMGO activate distinct , ligand-specific , conformations of MOR . Positive_regulation EPHB2 MAP2K2 18401006 1925751 CyaA enhanced LPS induced phosphorylation of p38 MAPK and [ERK] in DC , and inhibitors of p38 MAPK , , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation EPHB2 MAP2K2 18454176 1951541 Moreover , GATA-6 was phosphorylated at serine residues by *activated* [ERK] , which increased GATA-6 DNA binding , correlating with suppression of the Nox1 promoter activity by an MEK inhibitor PD98059 . Positive_regulation EPHB2 MAP2K2 18632602 1937014 A selective inhibitor , AZD6244 , *inhibits* mutant induced [ERK] activity in 293T cells and growth of mutant bearing Ba/F3 cells . Positive_regulation EPHB2 MAP2K2 18656513 1972851 was *required* for phosphorylation of [ERK] and CREB , but not Akt , whereas G ( 0 ) /G ( i ) -proteins were necessary for phosphorylation of Akt and CREB , and cGMP was necessary for Akt phosphorylation . Positive_regulation EPHB2 MAP2K2 18695640 1973869 ROCK inhibition also reduced 5-HT stimulated proliferation by suppressing *stimulated* [ERK] phosphorylation . Positive_regulation EPHB2 MAP2K2 18711316 2005999 Moreover , pretreatment with DIDS ( Cl- channel blockers ) but not LY294002 ( PI3K inhibitors ) completely abolished the LDL induced upregulation of Egr-1 to the same extent as PD98059 ( inhibitors to *inhibit* [Erk] ) , as judged by Western blot and luciferase reporter assays . Positive_regulation EPHB2 MAP2K2 18771726 1980332 We demonstrated here , that PTPIP51 could regulate ERK activity on Raf level , since inhibitor and dominant negative Raf-1 but not Ras could *inhibit* the [ERK] activation induced by PTPIP51 . Positive_regulation EPHB2 MAP2K2 19098317 2047660 PI3K inhibitor ( Ly294002 ) significantly decreased pAkt activity and HIF-1alpha and VEGF expression in vivo and in vitro , whereas inhibitor ( PD98059 ) *reduced* [ERK] phosphorylation and the expression of VEGF but had no effect on HIF-1alpha . Positive_regulation EPHB2 MAP2K2 19176641 2061148 U-0126 , the ( MAPK kinase ) inhibitors *blocked* [ERK] activation and cell proliferation induced by diazoxide . Positive_regulation EPHB2 MAP2K2 19219045 2044426 Here we describe a previously uncharacterized , unexpected role of Mek1 in downregulating *dependent* [Erk] signaling . Positive_regulation EPHB2 MAP2K2 19219045 2044450 Thus , in disagreement with the current perception of the pathway , the *role* of Mek1 and in growth factor induced [Erk] phosphorylation is not interchangeable . Positive_regulation EPHB2 MAP2K2 19241161 2086556 Furthermore , we also demonstrated here that Zn2+ stimulates the phosphorylation of [ERK] and that the pathway inhibitor , U0126 , *suppressed* Zn2+ induced PUMA expression . Positive_regulation EPHB2 MAP2K2 19319189 2052419 multiprotein complex to *promote* sustained [ERK] activation and regulate H-Ras dependent neuritogenesis . Positive_regulation EPHB2 MAP2K2 19703440 2158079 Furthermore , [ERK] activation and angiogenic sprouting in response to NMB are significantly *blocked* by the inhibitor . Positive_regulation EPHB2 MAP2K2 20526801 2320140 Furthermore , we also demonstrate that either chemical inhibition of ( U0126 ) or stable downregulation of PDGFRß by shRNA similarly results in the *loss* of PDGF induced [ERK] phosphorylation and abolishes Rac1/Pak1 activation and cell migration in response to PDGF . Positive_regulation EPHB2 MAP2K2 20542106 2301953 Activation of these pathways by ATP seemed to be independent , since LY294002 and U0126 , inhibitors of PI3K and , did not *block* the activation of [ERK] and AKT , respectively , although each compound blocked its respective target . Positive_regulation EPHB2 MAP2K2 20668238 2305303 inhibitors *inhibit* [ERK] phosphorylation in all normal and tumor cells , whereas PLX4032 inhibits ERK signaling only in tumor cells expressing BRAF ( V600E ) . Positive_regulation EPHB2 MAP2K2 20668435 2317104 In addition , DHA caused AKT and [ERK] activation in a time dependent manner , and the DHA induced HO-1 upregulation could be *attenuated* by PI-3 kinase/AKT and inhibitors . Positive_regulation EPHB2 MAP2K2 21088259 2389772 These cells displayed high levels of ERK activation , that is , at least in part , independent of the conventional RAF/MEK/ERK pathway , as MEK activation was low and inhibition of did not significantly *block* activation of [ERK] . Positive_regulation EPHB2 MAP2K2 21106560 2395796 Experiments carried out with pharmacological inhibitors show that *dependent* [ERK] and phosphatidylinositol 3-kinase dependent AKT pathways are positive regulators of the lectin- and insulin mediated adipogenic differentiation , while stress activated kinase/c-jun N-terminal kinase pathway acts as a negative one . Positive_regulation EPHB2 MAP2K2 21336309 2399443 Expression of un-SUMOylatable *enhanced* [ERK] activation , cell differentiation , proliferation and malignant transformation by oncogenic ErbB2 or Raf , but not by active Ras . Positive_regulation EPHB2 MAP2K2 21665194 2446301 inhibitors and alpha7-nicotinic acetylcholine receptor ( a7nAChR ) antagonist *blocked* the neurite outgrowth and the activation of [ERK] induced by B12H . Positive_regulation EPHB2 MAP2K2 22085529 2534361 Mitogen activated protein kinase kinase ( inhibitor , UO126 and [ERK] *inhibitor* II , FR180204 blocked the Elk-1 phosphorylation and activation . Positive_regulation EPHB2 MAP2K2 22087839 2514173 Therefore , inhibition of mediated [ERK] *activation* is very appealing in cancer therapy . Positive_regulation EPHB2 MAP2K2 22087839 2514180 Inhibition of mediated [ERK] *activation* , therefore , compromises checkpoint activation . Positive_regulation EPHB2 MAP2K2 22278923 2551570 By contrast , in human embryos , inhibition of MEK did not significantly alter epiblast or hypoblast precursor numbers despite the ability of the inhibitor to potently *inhibit* [ERK] phosphorylation in human ES cells . Positive_regulation EPHB2 MAP2K2 22328534 2642852 PD98059 , inhibitor , or U0126 , [ERK] *inhibitor* , reduced SNU668 cell migration accompanying an increase in p-GSK-3a , ß-catenin and E-cadherin . Positive_regulation EPHB2 MAP2K2 22556409 2614115 [ERK] activation was *prevented* by inhibitors and was associated with concurrent stimulation of RAF kinase activity but not RAS activation . Positive_regulation EPHB2 MAP2K2 22740332 2715439 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Positive_regulation EPHB2 MAP2K2 22785235 2691764 TRH induced CRE promoter was inhibited by mitogen activated protein [kinase/ERK] kinase ( MEK ) inhibitor and was *increased* by overexpression of . Positive_regulation EPHB2 MAP2K2 22892241 2666328 However , unlike ( V600E ) Braf , [Mek/Erk] pathway activation was mediated by both Craf and Braf , and ATP-competitive RAF inhibitors *induced* paradoxical pathway activation . Positive_regulation EPHB2 MAP2K2 22906417 2678030 Furthermore , post-EMT cells exhibited decreased basal Raf and [Erk] phosphorylation , and in comparison to pre-EMT cells , their proliferation was poorly *inhibited* by a inhibitor . Positive_regulation EPHB2 MAP2K2 23102728 2729190 inhibitors , either AZD6244 or CI1040 , *inhibited* [ERK] phosphorylation and sensitized gefitinib induced cytotoxicity in PC-9/gef cells . Positive_regulation EPHB2 MAP2K2 23210697 2736380 Complete [ERK] *activation* by the kinase requires dual phosphorylation at T and Y within the activation motif TEY . Positive_regulation EPHB2 MAP2K2 23360980 2758731 Consequently , coexpression of wildtype C-Raf and was *sufficient* for full and constitutive activation of [ERK] . Positive_regulation EPHB2 MAP2K2 23499828 2827632 H2S stimulated T cell activation by potentiating *dependent* [ERK] phosphorylation , and thrombospondin-1 inhibited this signaling in a CD47 dependent manner . Positive_regulation EPHB2 MAP2K2 23806683 2820633 [ERK] *activation* by the over-expression of constitutively active increased protein levels and enhanced the stability of SIRT2 . Positive_regulation EPHB2 MAP2K2 24530412 2924277 It is noteworthy that a tyrosine kinase receptor inhibitor , K252a , an inhibitor ( U0126 ) , and a PI3Kinase-Akt inhibitor ( LY294002 ) remarkably *attenuated* TrkB , [ERK] , and Akt phosphorylation as well as increase of OPN mRNA expression in the HCEM cells , respectively . Positive_regulation EPHB2 MAP2K2 24746704 2936458 Here , we found that inhibitors *suppress* [ERK] signaling more potently in BRAF ( V600E ) , than in KRAS mutant tumors . Positive_regulation EPHB2 MAP2K2 8226933 235290 *Activation* of extracellular signal regulated kinase ( [ERK] ) or mitogen activated protein kinase by ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation EPHB2 MAP2K2 8226933 235471 is the most active [ERK] *activator* . Positive_regulation EPHB2 MAP2K2 8552085 347154 Expression of a dominant interfering mutant , in which lysine 97 was replaced with arginine ( MEK/K97R ) , *resulted* in an inhibition of insulin stimulated SOS and [ERK] phosphorylation , whereas expression of a constitutively active MEK mutant , in which serines 218 and 222 were replaced with glutamic acid ( MEK/EE ) , induced basal phosphorylation of both SOS and ERK . Positive_regulation EPHB2 MAP2K2 9149902 430091 These findings suggest that may be the primary [Erk/MAP] kinase *activator* during development and that MEK1 may play a role in the proliferative or mitogenic response in adult mouse tissues . Positive_regulation EPHB2 MAP2K2 9390997 467673 Furthermore , overexpression of a kinase-inactive mutant *inhibited* phorbol ester stimulation of APP secretion and activation of [ERK] in human embryonic kidney cell lines . Positive_regulation EPHB2 MAP2K2 9442025 482987 Arsenite induced [ERK] activation is *mediated* by Ras , Raf , and but appears to be independent of de novo protein synthesis . Positive_regulation EPHB2 MAP2K2 9687508 522237 Consistently , *induced* [ERK] activation in PC12 cells induces c-Jun expression , while JNK signalling does not . Positive_regulation EPHB2 MAP2K2 9826736 550735 Inhibition of ( proximal activator of Erk ) also *blocked* stimulation of [Erk] and adhesion by formylmethionyl-leucyl-phenylalanineand arachidonic acid . Positive_regulation EPHB2 MAP2K2 9864179 582699 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of [ERK] , but not p38 MAPK , induced by G-CSF , GM-CSF , or TNF . Positive_regulation EPHB2 MAP2K3 10383890 624669 The inhibitor , PD 098059 *inhibited* EGF stimulated proliferation and [ERK] activity in a parallel , dose dependent manner showing that ERK activation is at least permissive for the proliferative response to EGF . Positive_regulation EPHB2 MAP2K3 10402467 628940 Ras and were *necessary* and sufficient for uPA induced [ERK] activation and stimulation of cellular migration , as demonstrated in experiments with dominant negative and constitutively active mutants of these signaling proteins . Positive_regulation EPHB2 MAP2K3 10523856 653794 The inhibitor PD 098059 , as well as the PKC inhibitors , completely *blocked* TPA mediated [ERK] activation . Positive_regulation EPHB2 MAP2K3 10688043 669956 Inhibition of EGF- and LPA- induced [ERK] activation with the EGF receptor inhibitor , AG1478 , or the inhibitor , PD98059 , *attenuated* their proliferative effects . Positive_regulation EPHB2 MAP2K3 10700616 672424 We have therefore hypothesized that [ERK] *activation* through is required for optimal induction of neurite growth by these proteins . Positive_regulation EPHB2 MAP2K3 10783161 688172 Sur-8 expression enhances Ras- or EGF induced Raf and ERK activation but has no effect on [ERK] activation *induced* by active Raf or . Positive_regulation EPHB2 MAP2K3 10888263 710242 However , PD098059 mediated inhibition of *dependent* stimulation of [ERK] did not alter the hypertrophic response of either agonist . Positive_regulation EPHB2 MAP2K3 10965502 727989 17 beta-oestradiol increased B-Raf activity and *dependent* [ERK] phosphorylation in explants of wild-type and ERKO cerebral cortex . Positive_regulation EPHB2 MAP2K3 10996792 733908 As in proliferating cells , [ERK] activation during G0 *required* the MAPkinase kinase and was partially dependent on cell adhesion . Positive_regulation EPHB2 MAP2K3 11005808 752392 A inhibitor , PD98059 , *inhibited* heat shock [ERK] MAPK activation by > 75 % . Positive_regulation EPHB2 MAP2K3 11311983 805180 This provides evidence for a novel pathway linking striatal kainate receptors to [ERK] *activation* via PI3 kinase and . Positive_regulation EPHB2 MAP2K3 11359871 816500 6-OHDA elicited ERK phosphorylation was blocked by PD98059 , an inhibitor of the upstream ( MEK ) that phosphorylates and *activates* [ERK] . Positive_regulation EPHB2 MAP2K3 11413312 828900 The inhibitors PD98059 and U0126 *blocked* [Erk] activation and release of IL-8 following infection with Ad7 . Positive_regulation EPHB2 MAP2K3 11418608 843266 VPA induced *activation* of [ERK] was blocked by the mitogen activated protein kinase/ERK kinase inhibitor PD098059 and dominant negative Ras and Raf mutants but not by dominant negative stress activated protein kinase/ERK kinase and 6 mutants . Positive_regulation EPHB2 MAP2K3 11546664 856570 The mitogen activated protein kinase (MAPK) kinase ( ) inhibitors , PD-98059 and U-0126 , *blocked* IL-1 alpha induced [ERK] activation and partially attenuated cPLA(2)alpha phosphorylation and PGI ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation EPHB2 MAP2K3 11564685 863260 The specific Mek inhibitor , PD98059 , blocked the activation of the Erks by ACTH and basic fibroblast growth factor , indicating that is the upstream *activator* of [Erk] . Positive_regulation EPHB2 MAP2K3 11641250 872078 Stimulation of [Erk] activity was *due* to activation of Ras , Raf-1 , and ( MAPK kinase ) . Positive_regulation EPHB2 MAP2K3 11804669 903325 PD 98059 , a inhibitor , and glutathione , an anti-thiol-oxidant , not only *blocked* Cpd 5-induced [ERK] phosphorylation , but also antagonized the activation of CPP-32 , the altered Bcl-2/Bax expression , and DNA fragmentation . Positive_regulation EPHB2 MAP2K3 11812003 907190 The inhibitors , U0126 and PD-98059 , dose-dependently *inhibited* the [ERK] activity stimulated by EGF . Positive_regulation EPHB2 MAP2K3 11841924 912278 PMA also phosphorylated MEK and [ERK] , and PMA induced GATA-4 phosphorylation was *blocked* by an inhibitor , PD98059 , suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway . Positive_regulation EPHB2 MAP2K3 12055096 951681 The inhibitors PD-98059 and U-0126 *blocked* [ERK] activation mediated by diazoxide . Positive_regulation EPHB2 MAP2K3 12070086 955770 Addition of inhibitor in the culture medium *prevented* [ERK] activation and metamorphosis . Positive_regulation EPHB2 MAP2K3 12364324 1019136 GLP1 stimulated activation of [Erk] is *blocked* by inhibitors of , but GLP1 does not induce the activation of A-Raf , B-Raf , C-Raf , or Ras . Positive_regulation EPHB2 MAP2K3 12493768 1056682 Consistent with this premise , FSH stimulated [ERK] activation is *inhibited* by the cell-permeable protein kinase A-specific inhibitor peptide Myr-PKI as well as by inhibitors of , Src , a Ca ( 2+ ) channel blocker , and chelation of extracellular Ca ( 2+ ) . Positive_regulation EPHB2 MAP2K3 12506070 1038323 A specific inhibitor of *blocked* the TNFalpha induction of the MMPs and TIMPs and the phosphorylation of [Erk] . Positive_regulation EPHB2 MAP2K3 12514175 1063803 Low K ( + ) *induced* delayed and persistent [ERK] activation , which was blocked by inhibitors or GDF-15 . Positive_regulation EPHB2 MAP2K3 12588763 1059634 inhibitors U0126 and PD98059 *blocked* both [ERK] activation and the increase in TF mRNA . Positive_regulation EPHB2 MAP2K3 12657694 1073286 [ERK] activation was *blocked* by inhibiting , the upstream activator of ERK . Positive_regulation EPHB2 MAP2K3 12664642 1030351 Inhibition of ( proximal activator of Erk ) also *blocked* stimulation of [Erk] and neutrophil aggregation by FMLP and arachidonic acid . Positive_regulation EPHB2 MAP2K3 12675684 1076699 In contrast , the *activation* of [ERK] by constitutively active forms of was not inhibited , suggesting that the actions of SptP were mediated by Raf-1 . Positive_regulation EPHB2 MAP2K3 12686598 1078125 In unstimulated cells , tropomyosin-1 was found diffuse in the cells , whereas it quickly colocalized with actin and stress fibers upon *stimulation* of [ERK] by H ( 2 ) O ( 2 ) or by expression of ( CA ) . Positive_regulation EPHB2 MAP2K3 12706116 1082484 In PC12 cells , NGF and EGF induce a rapid translocation of [GFP-Erk] that *requires* Ras and . Positive_regulation EPHB2 MAP2K3 12736249 1107188 We observed that growth stimulation was associated with stimulation of ERK1/2 phosphorylation (ERK-P) , and both growth and [ERK-P] could be *blocked* by the inhibitor ( U0126 , 100 nm ) . Positive_regulation EPHB2 MAP2K3 12738796 1107265 Surprisingly , this induction of phosphorylation does not *result* in [ERK] activation in vivo . Positive_regulation EPHB2 MAP2K3 12758056 1090983 Inhibition of *induced* [ERK] phosphorylation had no effect on adipogenesis but prevented this TCDD suppression . Positive_regulation EPHB2 MAP2K3 12850584 1109564 Abeta induced [ERK] phosphorylation was completely *blocked* by the inhibitors , while Abeta induced promotion of extracellular L-glutamate clearance was enhanced by the presence of the MEK inhibitors . Positive_regulation EPHB2 MAP2K3 14514659 1185726 A low level ( 2 micro M ) of arsenite stimulated extracellular signal regulated kinase ( ERK ) signaling pathway and enhanced cell proliferation , and this arsenite induced [ERK] activity was *blocked* by inhibitor , PD98059 . Positive_regulation EPHB2 MAP2K3 14517212 1164975 The inhibitors PD 98059 and U0126 *blocked* [ERK] phosphorylation , as did the adenylate cyclase activator forskolin . Positive_regulation EPHB2 MAP2K3 14555984 1153213 In androgen depleted condition , PD98059 , an inhibitor , could efficiently *block* not only the activation of [ERK] , but also the acquisition of the NE-like morphology and the elevation of NSE in C-33 LNCaP cells . Positive_regulation EPHB2 MAP2K3 14563359 1154807 Experiments based on inhibitors of specific signaling pathways , such as manumycin A , toxin A , U0126 , PD98059 and wortmannin revealed that Ras , and PI-3K are *involved* in the activation of [ERK] . Positive_regulation EPHB2 MAP2K3 14688282 1211510 However , PD98059 , a specific inhibitor of ( MEK1 ) , *inhibited* [ERK] activation by TGF-beta(1) , and consequently attenuated TGF-beta(1) enhancement of its own mRNA expression in PSCs . Positive_regulation EPHB2 MAP2K3 14719071 1197688 In cisplatin-resistant UM-SCC-23 in culture , which we have established , the protein levels of Ras , Raf-1 and were drastically elevated compared to parent UM-SCC-23 , and [ERK] and Akt signals were constitutively *activated* . Positive_regulation EPHB2 MAP2K3 15159408 1273321 Use of U0126 revealed that palytoxin *requires* the ERK kinase to stimulate [ERK] activity , although palytoxin did not activate MEK . Positive_regulation EPHB2 MAP2K3 15174091 1254266 Conversely , treatment with U0126 , a potent inhibitor of mediated [ERK] *activation* , prevented FAK phosphorylation at Ser-910 induced by PDGF but did not interfere with PDGF induced FAK phosphorylation at Tyr-397 . Positive_regulation EPHB2 MAP2K3 15304546 1322381 Furthermore , *activation* of [ERK/MAPK] by the coexpression of constitutively active predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation EPHB2 MAP2K3 15537634 1360472 [ERK] activation was *prevented* by inhibitors that had no effect on PYK2 . Positive_regulation EPHB2 MAP2K3 15607817 1357027 Furthermore , U0126 and LY294002 , which respectively inhibit *induced* [ERK] phosphorylation and PI3 kinase mediated Akt phosphorylation had distinct effects on C3a induced responses . Positive_regulation EPHB2 MAP2K3 15652235 1364132 PD98059 , a inhibitor , and BAY 11-8702 , an I kappa B-alpha inhibitor , *reduced* [ERK] and NF-kappa B cascade activation , respectively , with little effect on PKC phosphorylation . Positive_regulation EPHB2 MAP2K3 15674440 1350825 [ERK] phosphorylation was *reduced* by a inhibitor , PD98059 . Positive_regulation EPHB2 MAP2K3 15691837 1388548 In its central portion *activates* [ERK] , leading to increased collagen expression . Positive_regulation EPHB2 MAP2K3 15749869 1379689 We found that prior stimulation of primary murine B cells with CD40L markedly enhanced the level of ERK and JNK ( but not p38 MAPK ) phosphorylation produced by subsequently added anti-Ig Ab , and much , but not all , of this enhancement was independent of PI3K and phospholipase C . CD40L treatment similarly enhanced BCR induced MAPK kinase ( MEK ) phosphorylation , and was *required* for enhancement of [ERK] . Positive_regulation EPHB2 MAP2K3 15750341 1379871 These findings indicate that [ERK] phosphorylation in response to glycated LDL *involves* the activation of PKC , PLC , and , but is independent of intracellular Ca2+ . Positive_regulation EPHB2 MAP2K3 15801908 1432341 The ( MAPK/ERK kinase ) inhibitors PD98059 and U0126 *blocked* IGF-I stimulated [ERK] phosphorylation but did not block the phosphorylation of Akt and did not decrease proteoglycan synthesis . Positive_regulation EPHB2 MAP2K3 15843032 1398307 Treatment of myoblasts with LIF induced phosphorylation of [ERK] , and the LIF induced inhibitory effect on myogenesis was *blocked* by pretreatment with U0126 , a specific inhibitor , and transient transfection with dominant negative ( DN ) -MEK1 . Positive_regulation EPHB2 MAP2K3 15843535 1398464 As in the classical pathway , BCR induced [ERK] activation in the new , PI3K independent pathway *required* and was reflected in c-Raf . Positive_regulation EPHB2 MAP2K3 15855657 1439587 Activation of ERK was attenuated by drugs that disassemble the actin cytoskeleton ( cytochalasin D , latrunculin B ) , and these compounds interfered with the *activation* of [ERK] by ( MEK ) . Positive_regulation EPHB2 MAP2K3 16189274 1507732 In MET positive DLBCL cells , HGF induces dependent *activation* of [ERK] and PI3K dependent phosphorylation of PKB , GSK3 , and FOXO3a . Positive_regulation EPHB2 MAP2K3 16360949 1504581 The phospho-ERK and phospho-MEK profiles were similar , suggesting that [ERK] phosphorylation is *regulated* by . Positive_regulation EPHB2 MAP2K3 16877565 1638798 However , inhibitors of Raf-1 and or a dominant negative ERK mutant *blocked* FKN induced [ERK] , but not Akt and eNOS , phosphorylation . Positive_regulation EPHB2 MAP2K3 16983658 1633617 In parallel , farnesyltransferase and inhibitors *blocked* [ERK] phosphorylation and neuroprotective effect of NAC . Positive_regulation EPHB2 MAP2K3 17130674 1661368 PD98059 , a ( mitogen activated protein kinase kinase ) inhibitor , and BAPTA-AM [ O , O'-bis ( 2-aminophenyl ) ethyleneglycol-N , N,N ' , N'-tetraacetic acid , tetraacetoxymethyl ester ] , an intracellular Ca ( 2+ ) chelator , *reduced* UTP induced [ERK] phosphorylation and IL-6 mRNA expression . Positive_regulation EPHB2 MAP2K3 17182785 1662665 Specifically , inhibition of GSK-3beta led to increased [ERK] phosphorylation , and inhibition of completely *blocked* the effects of GSK-3beta inhibition on dendrite initiation and growth . Positive_regulation EPHB2 MAP2K3 17189385 1662769 In addition , inhibitor ( PD98059 ) *reduced* the interaction between p65 and [ERK] . Positive_regulation EPHB2 MAP2K3 17337598 1765819 A pharmacological inhibitor of activity *inhibits* LPA stimulated WT Hic-5 cell migration and [ERK] phosphorylation , suggesting Hic-5 enhances migration via MEK activation of ERK . Positive_regulation EPHB2 MAP2K3 17379261 1720777 FTY720P augmented [ERK] phosphorylation in cortical cultures prepared from embryonic day 18 rat brains and was *blocked* by an inhibitor or by pertussis toxin . Positive_regulation EPHB2 MAP2K3 17526574 1784068 , once phosphorylated by Raf , *triggers* [Erk] phosphorylation , which in turn induces dissociation of Raf-inaccessible Mek-Erk heterodimers , and thus further amplifies Mek phosphorylation . Positive_regulation EPHB2 MAP2K3 18068691 1853770 This mechanism was found to be specific to etorphine , as activation of [ERK] by the micro-opioid receptor ( MOR ) agonist DAMGO ( [ D-Ala ( 2 ) , N-Me-Phe ( 4 ) , Gly ( 5 ) -ol ] enkephalin ) was *mediated* by in these cells , suggesting that etorphine and DAMGO activate distinct , ligand-specific , conformations of MOR . Positive_regulation EPHB2 MAP2K3 18401006 1925752 CyaA enhanced LPS induced phosphorylation of p38 MAPK and [ERK] in DC , and inhibitors of p38 MAPK , , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation EPHB2 MAP2K3 18454176 1951542 Moreover , GATA-6 was phosphorylated at serine residues by *activated* [ERK] , which increased GATA-6 DNA binding , correlating with suppression of the Nox1 promoter activity by an MEK inhibitor PD98059 . Positive_regulation EPHB2 MAP2K3 18632602 1937015 A selective inhibitor , AZD6244 , *inhibits* mutant induced [ERK] activity in 293T cells and growth of mutant bearing Ba/F3 cells . Positive_regulation EPHB2 MAP2K3 18656513 1972852 was *required* for phosphorylation of [ERK] and CREB , but not Akt , whereas G ( 0 ) /G ( i ) -proteins were necessary for phosphorylation of Akt and CREB , and cGMP was necessary for Akt phosphorylation . Positive_regulation EPHB2 MAP2K3 18695640 1973870 ROCK inhibition also reduced 5-HT stimulated proliferation by suppressing *stimulated* [ERK] phosphorylation . Positive_regulation EPHB2 MAP2K3 18711316 2006000 Moreover , pretreatment with DIDS ( Cl- channel blockers ) but not LY294002 ( PI3K inhibitors ) completely abolished the LDL induced upregulation of Egr-1 to the same extent as PD98059 ( inhibitors to *inhibit* [Erk] ) , as judged by Western blot and luciferase reporter assays . Positive_regulation EPHB2 MAP2K3 18771726 1980333 We demonstrated here , that PTPIP51 could regulate ERK activity on Raf level , since inhibitor and dominant negative Raf-1 but not Ras could *inhibit* the [ERK] activation induced by PTPIP51 . Positive_regulation EPHB2 MAP2K3 19098317 2047661 PI3K inhibitor ( Ly294002 ) significantly decreased pAkt activity and HIF-1alpha and VEGF expression in vivo and in vitro , whereas inhibitor ( PD98059 ) *reduced* [ERK] phosphorylation and the expression of VEGF but had no effect on HIF-1alpha . Positive_regulation EPHB2 MAP2K3 19176641 2061149 U-0126 , the ( MAPK kinase ) inhibitors *blocked* [ERK] activation and cell proliferation induced by diazoxide . Positive_regulation EPHB2 MAP2K3 19241161 2086557 Furthermore , we also demonstrated here that Zn2+ stimulates the phosphorylation of [ERK] and that the pathway inhibitor , U0126 , *suppressed* Zn2+ induced PUMA expression . Positive_regulation EPHB2 MAP2K3 19319189 2052420 multiprotein complex to *promote* sustained [ERK] activation and regulate H-Ras dependent neuritogenesis . Positive_regulation EPHB2 MAP2K3 19703440 2158080 Furthermore , [ERK] activation and angiogenic sprouting in response to NMB are significantly *blocked* by the inhibitor . Positive_regulation EPHB2 MAP2K3 20526801 2320141 Furthermore , we also demonstrate that either chemical inhibition of ( U0126 ) or stable downregulation of PDGFRß by shRNA similarly *results* in the loss of PDGF induced [ERK] phosphorylation and abolishes Rac1/Pak1 activation and cell migration in response to PDGF . Positive_regulation EPHB2 MAP2K3 20542106 2301954 Activation of these pathways by ATP seemed to be independent , since LY294002 and U0126 , inhibitors of PI3K and , did not *block* the activation of [ERK] and AKT , respectively , although each compound blocked its respective target . Positive_regulation EPHB2 MAP2K3 20668238 2305304 inhibitors *inhibit* [ERK] phosphorylation in all normal and tumor cells , whereas PLX4032 inhibits ERK signaling only in tumor cells expressing BRAF ( V600E ) . Positive_regulation EPHB2 MAP2K3 20668435 2317105 In addition , DHA caused AKT and [ERK] activation in a time dependent manner , and the DHA induced HO-1 upregulation could be *attenuated* by PI-3 kinase/AKT and inhibitors . Positive_regulation EPHB2 MAP2K3 21088259 2389773 These cells displayed high levels of ERK activation , that is , at least in part , independent of the conventional RAF/MEK/ERK pathway , as MEK activation was low and inhibition of did not significantly *block* activation of [ERK] . Positive_regulation EPHB2 MAP2K3 21106560 2395797 Experiments carried out with pharmacological inhibitors show that *dependent* [ERK] and phosphatidylinositol 3-kinase dependent AKT pathways are positive regulators of the lectin- and insulin mediated adipogenic differentiation , while stress activated kinase/c-jun N-terminal kinase pathway acts as a negative one . Positive_regulation EPHB2 MAP2K3 21336309 2399444 Expression of un-SUMOylatable *enhanced* [ERK] activation , cell differentiation , proliferation and malignant transformation by oncogenic ErbB2 or Raf , but not by active Ras . Positive_regulation EPHB2 MAP2K3 21665194 2446302 inhibitors and alpha7-nicotinic acetylcholine receptor ( a7nAChR ) antagonist *blocked* the neurite outgrowth and the activation of [ERK] induced by B12H . Positive_regulation EPHB2 MAP2K3 22087839 2514174 Therefore , inhibition of mediated [ERK] *activation* is very appealing in cancer therapy . Positive_regulation EPHB2 MAP2K3 22087839 2514181 Inhibition of mediated [ERK] *activation* , therefore , compromises checkpoint activation . Positive_regulation EPHB2 MAP2K3 22278923 2551571 By contrast , in human embryos , inhibition of MEK did not significantly alter epiblast or hypoblast precursor numbers despite the ability of the inhibitor to potently *inhibit* [ERK] phosphorylation in human ES cells . Positive_regulation EPHB2 MAP2K3 22328534 2642853 PD98059 , inhibitor , or U0126 , [ERK] *inhibitor* , reduced SNU668 cell migration accompanying an increase in p-GSK-3a , ß-catenin and E-cadherin . Positive_regulation EPHB2 MAP2K3 22556409 2614116 [ERK] activation was *prevented* by inhibitors and was associated with concurrent stimulation of RAF kinase activity but not RAS activation . Positive_regulation EPHB2 MAP2K3 22740332 2715440 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Positive_regulation EPHB2 MAP2K3 22785235 2691765 TRH induced CRE promoter was inhibited by mitogen activated protein [kinase/ERK] kinase ( MEK ) inhibitor and was *increased* by overexpression of . Positive_regulation EPHB2 MAP2K3 22892241 2666329 However , unlike ( V600E ) Braf , pathway activation was mediated by both Craf and Braf , and ATP-competitive RAF inhibitors *induced* paradoxical [Mek/Erk] pathway activation . Positive_regulation EPHB2 MAP2K3 22906417 2678031 Furthermore , post-EMT cells exhibited decreased basal Raf and [Erk] phosphorylation , and in comparison to pre-EMT cells , their proliferation was poorly *inhibited* by a inhibitor . Positive_regulation EPHB2 MAP2K3 23102728 2729191 inhibitors , either AZD6244 or CI1040 , *inhibited* [ERK] phosphorylation and sensitized gefitinib induced cytotoxicity in PC-9/gef cells . Positive_regulation EPHB2 MAP2K3 23210697 2736381 Complete [ERK] *activation* by the kinase requires dual phosphorylation at T and Y within the activation motif TEY . Positive_regulation EPHB2 MAP2K3 23360980 2758732 Consequently , coexpression of wildtype C-Raf and was *sufficient* for full and constitutive activation of [ERK] . Positive_regulation EPHB2 MAP2K3 23499828 2827633 H2S stimulated T cell activation by potentiating *dependent* [ERK] phosphorylation , and thrombospondin-1 inhibited this signaling in a CD47 dependent manner . Positive_regulation EPHB2 MAP2K3 23806683 2820634 [ERK] *activation* by the over-expression of constitutively active increased protein levels and enhanced the stability of SIRT2 . Positive_regulation EPHB2 MAP2K3 24530412 2924278 It is noteworthy that a tyrosine kinase receptor inhibitor , K252a , an inhibitor ( U0126 ) , and a PI3Kinase-Akt inhibitor ( LY294002 ) remarkably *attenuated* TrkB , [ERK] , and Akt phosphorylation as well as increase of OPN mRNA expression in the HCEM cells , respectively . Positive_regulation EPHB2 MAP2K3 24746704 2936459 Here , we found that inhibitors *suppress* [ERK] signaling more potently in BRAF ( V600E ) , than in KRAS mutant tumors . Positive_regulation EPHB2 MAP2K3 8226933 235291 *Activation* of extracellular signal regulated kinase ( [ERK] ) or mitogen activated protein kinase by ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation EPHB2 MAP2K3 8552085 347155 Expression of a dominant interfering mutant , in which lysine 97 was replaced with arginine ( MEK/K97R ) , *resulted* in an inhibition of insulin stimulated SOS and [ERK] phosphorylation , whereas expression of a constitutively active MEK mutant , in which serines 218 and 222 were replaced with glutamic acid ( MEK/EE ) , induced basal phosphorylation of both SOS and ERK . Positive_regulation EPHB2 MAP2K3 9390997 467674 Furthermore , overexpression of a kinase-inactive mutant *inhibited* phorbol ester stimulation of APP secretion and activation of [ERK] in human embryonic kidney cell lines . Positive_regulation EPHB2 MAP2K3 9442025 482988 Arsenite induced [ERK] activation is *mediated* by Ras , Raf , and but appears to be independent of de novo protein synthesis . Positive_regulation EPHB2 MAP2K3 9687508 522238 Consistently , induced [ERK] *activation* in PC12 cells induces c-Jun expression , while JNK signalling does not . Positive_regulation EPHB2 MAP2K3 9826736 550736 Inhibition of ( proximal activator of Erk ) also *blocked* stimulation of [Erk] and adhesion by formylmethionyl-leucyl-phenylalanineand arachidonic acid . Positive_regulation EPHB2 MAP2K3 9864179 582700 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of [ERK] , but not p38 MAPK , induced by G-CSF , GM-CSF , or TNF . Positive_regulation EPHB2 MAP2K4 10383890 624670 The inhibitor , PD 098059 *inhibited* EGF stimulated proliferation and [ERK] activity in a parallel , dose dependent manner showing that ERK activation is at least permissive for the proliferative response to EGF . Positive_regulation EPHB2 MAP2K4 10402467 628941 Ras and were *necessary* and sufficient for uPA induced [ERK] activation and stimulation of cellular migration , as demonstrated in experiments with dominant negative and constitutively active mutants of these signaling proteins . Positive_regulation EPHB2 MAP2K4 10523856 653795 The inhibitor PD 098059 , as well as the PKC inhibitors , completely *blocked* TPA mediated [ERK] activation . Positive_regulation EPHB2 MAP2K4 10688043 669957 Inhibition of EGF- and LPA- induced [ERK] activation with the EGF receptor inhibitor , AG1478 , or the inhibitor , PD98059 , *attenuated* their proliferative effects . Positive_regulation EPHB2 MAP2K4 10700616 672425 We have therefore hypothesized that [ERK] *activation* through is required for optimal induction of neurite growth by these proteins . Positive_regulation EPHB2 MAP2K4 10783161 688173 Sur-8 expression enhances Ras- or EGF induced Raf and ERK activation but has no effect on [ERK] activation *induced* by active Raf or . Positive_regulation EPHB2 MAP2K4 10888263 710243 However , PD098059 mediated inhibition of *dependent* stimulation of [ERK] did not alter the hypertrophic response of either agonist . Positive_regulation EPHB2 MAP2K4 10965502 727990 17 beta-oestradiol increased B-Raf activity and *dependent* [ERK] phosphorylation in explants of wild-type and ERKO cerebral cortex . Positive_regulation EPHB2 MAP2K4 10996792 733909 As in proliferating cells , [ERK] activation during G0 *required* the MAPkinase kinase and was partially dependent on cell adhesion . Positive_regulation EPHB2 MAP2K4 11005808 752393 A inhibitor , PD98059 , *inhibited* heat shock [ERK] MAPK activation by > 75 % . Positive_regulation EPHB2 MAP2K4 11311983 805181 This provides evidence for a novel pathway linking striatal kainate receptors to [ERK] *activation* via PI3 kinase and . Positive_regulation EPHB2 MAP2K4 11359871 816501 6-OHDA elicited ERK phosphorylation was blocked by PD98059 , an inhibitor of the upstream ( MEK ) that phosphorylates and *activates* [ERK] . Positive_regulation EPHB2 MAP2K4 11413312 828901 The inhibitors PD98059 and U0126 *blocked* [Erk] activation and release of IL-8 following infection with Ad7 . Positive_regulation EPHB2 MAP2K4 11418608 843267 VPA induced *activation* of [ERK] was blocked by the mitogen activated protein kinase/ERK kinase inhibitor PD098059 and dominant negative Ras and Raf mutants but not by dominant negative stress activated protein kinase/ERK kinase and 6 mutants . Positive_regulation EPHB2 MAP2K4 11546664 856571 The mitogen activated protein kinase (MAPK) kinase ( ) inhibitors , PD-98059 and U-0126 , *blocked* IL-1 alpha induced [ERK] activation and partially attenuated cPLA(2)alpha phosphorylation and PGI ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation EPHB2 MAP2K4 11564685 863261 The specific Mek inhibitor , PD98059 , blocked the activation of the Erks by ACTH and basic fibroblast growth factor , indicating that is the upstream *activator* of [Erk] . Positive_regulation EPHB2 MAP2K4 11641250 872079 Stimulation of [Erk] activity was *due* to activation of Ras , Raf-1 , and ( MAPK kinase ) . Positive_regulation EPHB2 MAP2K4 11804669 903326 PD 98059 , a inhibitor , and glutathione , an anti-thiol-oxidant , not only *blocked* Cpd 5-induced [ERK] phosphorylation , but also antagonized the activation of CPP-32 , the altered Bcl-2/Bax expression , and DNA fragmentation . Positive_regulation EPHB2 MAP2K4 11812003 907191 The inhibitors , U0126 and PD-98059 , dose-dependently *inhibited* the [ERK] activity stimulated by EGF . Positive_regulation EPHB2 MAP2K4 11841924 912279 PMA also phosphorylated MEK and [ERK] , and PMA induced GATA-4 phosphorylation was *blocked* by an inhibitor , PD98059 , suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway . Positive_regulation EPHB2 MAP2K4 12055096 951682 The inhibitors PD-98059 and U-0126 *blocked* [ERK] activation mediated by diazoxide . Positive_regulation EPHB2 MAP2K4 12070086 955771 Addition of inhibitor in the culture medium *prevented* [ERK] activation and metamorphosis . Positive_regulation EPHB2 MAP2K4 12364324 1019137 GLP1 stimulated activation of [Erk] is *blocked* by inhibitors of , but GLP1 does not induce the activation of A-Raf , B-Raf , C-Raf , or Ras . Positive_regulation EPHB2 MAP2K4 12493768 1056683 Consistent with this premise , FSH stimulated [ERK] activation is *inhibited* by the cell-permeable protein kinase A-specific inhibitor peptide Myr-PKI as well as by inhibitors of , Src , a Ca ( 2+ ) channel blocker , and chelation of extracellular Ca ( 2+ ) . Positive_regulation EPHB2 MAP2K4 12506070 1038324 A specific inhibitor of *blocked* the TNFalpha induction of the MMPs and TIMPs and the phosphorylation of [Erk] . Positive_regulation EPHB2 MAP2K4 12514175 1063804 Low K ( + ) *induced* delayed and persistent [ERK] activation , which was blocked by inhibitors or GDF-15 . Positive_regulation EPHB2 MAP2K4 12588763 1059635 inhibitors U0126 and PD98059 *blocked* both [ERK] activation and the increase in TF mRNA . Positive_regulation EPHB2 MAP2K4 12657694 1073287 [ERK] activation was *blocked* by inhibiting , the upstream activator of ERK . Positive_regulation EPHB2 MAP2K4 12664642 1030352 Inhibition of ( proximal activator of Erk ) also *blocked* stimulation of [Erk] and neutrophil aggregation by FMLP and arachidonic acid . Positive_regulation EPHB2 MAP2K4 12675684 1076700 In contrast , the *activation* of [ERK] by constitutively active forms of was not inhibited , suggesting that the actions of SptP were mediated by Raf-1 . Positive_regulation EPHB2 MAP2K4 12686598 1078126 In unstimulated cells , tropomyosin-1 was found diffuse in the cells , whereas it quickly colocalized with actin and stress fibers upon *stimulation* of [ERK] by H ( 2 ) O ( 2 ) or by expression of ( CA ) . Positive_regulation EPHB2 MAP2K4 12706116 1082485 In PC12 cells , NGF and EGF induce a rapid translocation of [GFP-Erk] that *requires* Ras and . Positive_regulation EPHB2 MAP2K4 12736249 1107189 We observed that growth stimulation was associated with stimulation of ERK1/2 phosphorylation (ERK-P) , and both growth and [ERK-P] could be *blocked* by the inhibitor ( U0126 , 100 nm ) . Positive_regulation EPHB2 MAP2K4 12738796 1107266 Surprisingly , this induction of phosphorylation does not *result* in [ERK] activation in vivo . Positive_regulation EPHB2 MAP2K4 12758056 1090984 Inhibition of *induced* [ERK] phosphorylation had no effect on adipogenesis but prevented this TCDD suppression . Positive_regulation EPHB2 MAP2K4 12850584 1109565 Abeta induced [ERK] phosphorylation was completely *blocked* by the inhibitors , while Abeta induced promotion of extracellular L-glutamate clearance was enhanced by the presence of the MEK inhibitors . Positive_regulation EPHB2 MAP2K4 14514659 1185727 A low level ( 2 micro M ) of arsenite stimulated extracellular signal regulated kinase ( ERK ) signaling pathway and enhanced cell proliferation , and this arsenite induced [ERK] activity was *blocked* by inhibitor , PD98059 . Positive_regulation EPHB2 MAP2K4 14517212 1164976 The inhibitors PD 98059 and U0126 *blocked* [ERK] phosphorylation , as did the adenylate cyclase activator forskolin . Positive_regulation EPHB2 MAP2K4 14555984 1153214 In androgen depleted condition , PD98059 , an inhibitor , could efficiently *block* not only the activation of [ERK] , but also the acquisition of the NE-like morphology and the elevation of NSE in C-33 LNCaP cells . Positive_regulation EPHB2 MAP2K4 14563359 1154808 Experiments based on inhibitors of specific signaling pathways , such as manumycin A , toxin A , U0126 , PD98059 and wortmannin revealed that Ras , and PI-3K are *involved* in the activation of [ERK] . Positive_regulation EPHB2 MAP2K4 14688282 1211511 However , PD98059 , a specific inhibitor of ( MEK1 ) , *inhibited* [ERK] activation by TGF-beta(1) , and consequently attenuated TGF-beta(1) enhancement of its own mRNA expression in PSCs . Positive_regulation EPHB2 MAP2K4 14719071 1197689 In cisplatin-resistant UM-SCC-23 in culture , which we have established , the protein levels of Ras , Raf-1 and were drastically elevated compared to parent UM-SCC-23 , and [ERK] and Akt signals were constitutively *activated* . Positive_regulation EPHB2 MAP2K4 15159408 1273322 Use of U0126 revealed that palytoxin *requires* the ERK kinase to stimulate [ERK] activity , although palytoxin did not activate MEK . Positive_regulation EPHB2 MAP2K4 15174091 1254267 Conversely , treatment with U0126 , a potent inhibitor of mediated [ERK] *activation* , prevented FAK phosphorylation at Ser-910 induced by PDGF but did not interfere with PDGF induced FAK phosphorylation at Tyr-397 . Positive_regulation EPHB2 MAP2K4 15304546 1322382 Furthermore , *activation* of [ERK/MAPK] by the coexpression of constitutively active predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation EPHB2 MAP2K4 15537634 1360473 [ERK] activation was *prevented* by inhibitors that had no effect on PYK2 . Positive_regulation EPHB2 MAP2K4 15607817 1357028 Furthermore , U0126 and LY294002 , which respectively inhibit *induced* [ERK] phosphorylation and PI3 kinase mediated Akt phosphorylation had distinct effects on C3a induced responses . Positive_regulation EPHB2 MAP2K4 15652235 1364133 PD98059 , a inhibitor , and BAY 11-8702 , an I kappa B-alpha inhibitor , *reduced* [ERK] and NF-kappa B cascade activation , respectively , with little effect on PKC phosphorylation . Positive_regulation EPHB2 MAP2K4 15674440 1350826 [ERK] phosphorylation was *reduced* by a inhibitor , PD98059 . Positive_regulation EPHB2 MAP2K4 15691837 1388549 In its central portion *activates* [ERK] , leading to increased collagen expression . Positive_regulation EPHB2 MAP2K4 15749869 1379690 We found that prior stimulation of primary murine B cells with CD40L markedly enhanced the level of ERK and JNK ( but not p38 MAPK ) phosphorylation produced by subsequently added anti-Ig Ab , and much , but not all , of this enhancement was independent of PI3K and phospholipase C . CD40L treatment similarly enhanced BCR induced MAPK kinase ( MEK ) phosphorylation , and was *required* for enhancement of [ERK] . Positive_regulation EPHB2 MAP2K4 15750341 1379872 These findings indicate that [ERK] phosphorylation in response to glycated LDL *involves* the activation of PKC , PLC , and , but is independent of intracellular Ca2+ . Positive_regulation EPHB2 MAP2K4 15801908 1432342 The ( MAPK/ERK kinase ) inhibitors PD98059 and U0126 *blocked* IGF-I stimulated [ERK] phosphorylation but did not block the phosphorylation of Akt and did not decrease proteoglycan synthesis . Positive_regulation EPHB2 MAP2K4 15843032 1398308 Treatment of myoblasts with LIF induced phosphorylation of [ERK] , and the LIF induced inhibitory effect on myogenesis was *blocked* by pretreatment with U0126 , a specific inhibitor , and transient transfection with dominant negative ( DN ) -MEK1 . Positive_regulation EPHB2 MAP2K4 15843535 1398465 As in the classical pathway , BCR induced [ERK] activation in the new , PI3K independent pathway *required* and was reflected in c-Raf . Positive_regulation EPHB2 MAP2K4 15855657 1439588 Activation of ERK was attenuated by drugs that disassemble the actin cytoskeleton ( cytochalasin D , latrunculin B ) , and these compounds interfered with the *activation* of [ERK] by ( MEK ) . Positive_regulation EPHB2 MAP2K4 15930517 1433898 Pretreatment of HDFs with EPA inhibited UV-induced MMP-1 expression in a dose dependent manner and also *inhibited* the UV-induced activation of [ERK] and JNK by inhibiting ERK kinase ( MEK1 ) and activation , respectively . Positive_regulation EPHB2 MAP2K4 16189274 1507733 In MET positive DLBCL cells , HGF induces *dependent* activation of [ERK] and PI3K dependent phosphorylation of PKB , GSK3 , and FOXO3a . Positive_regulation EPHB2 MAP2K4 16360949 1504582 The phospho-ERK and phospho-MEK profiles were similar , suggesting that [ERK] phosphorylation is *regulated* by . Positive_regulation EPHB2 MAP2K4 16413539 1514344 Pretreatment of HSFs with 2',4',7-THF inhibited UV-induced MMP-1 expression in a dose dependent manner , and also *inhibited* the UV-induced activations of [ERK] and JNK by inhibiting MEK1 and activation , respectively . Positive_regulation EPHB2 MAP2K4 16877565 1638799 However , inhibitors of Raf-1 and or a dominant negative ERK mutant *blocked* FKN induced [ERK] , but not Akt and eNOS , phosphorylation . Positive_regulation EPHB2 MAP2K4 16983658 1633618 In parallel , farnesyltransferase and inhibitors *blocked* [ERK] phosphorylation and neuroprotective effect of NAC . Positive_regulation EPHB2 MAP2K4 17130674 1661369 PD98059 , a ( mitogen activated protein kinase kinase ) inhibitor , and BAPTA-AM [ O , O'-bis ( 2-aminophenyl ) ethyleneglycol-N , N,N ' , N'-tetraacetic acid , tetraacetoxymethyl ester ] , an intracellular Ca ( 2+ ) chelator , *reduced* UTP induced [ERK] phosphorylation and IL-6 mRNA expression . Positive_regulation EPHB2 MAP2K4 17182785 1662666 Specifically , inhibition of GSK-3beta led to increased [ERK] phosphorylation , and inhibition of completely *blocked* the effects of GSK-3beta inhibition on dendrite initiation and growth . Positive_regulation EPHB2 MAP2K4 17189385 1662770 In addition , inhibitor ( PD98059 ) *reduced* the interaction between p65 and [ERK] . Positive_regulation EPHB2 MAP2K4 17337598 1765820 A pharmacological inhibitor of activity *inhibits* LPA stimulated WT Hic-5 cell migration and [ERK] phosphorylation , suggesting Hic-5 enhances migration via MEK activation of ERK . Positive_regulation EPHB2 MAP2K4 17379261 1720778 FTY720P augmented [ERK] phosphorylation in cortical cultures prepared from embryonic day 18 rat brains and was *blocked* by an inhibitor or by pertussis toxin . Positive_regulation EPHB2 MAP2K4 17526574 1784069 , once phosphorylated by Raf , *triggers* [Erk] phosphorylation , which in turn induces dissociation of Raf-inaccessible Mek-Erk heterodimers , and thus further amplifies Mek phosphorylation . Positive_regulation EPHB2 MAP2K4 18068691 1853771 This mechanism was found to be specific to etorphine , as activation of [ERK] by the micro-opioid receptor ( MOR ) agonist DAMGO ( [ D-Ala ( 2 ) , N-Me-Phe ( 4 ) , Gly ( 5 ) -ol ] enkephalin ) was *mediated* by in these cells , suggesting that etorphine and DAMGO activate distinct , ligand-specific , conformations of MOR . Positive_regulation EPHB2 MAP2K4 18401006 1925753 CyaA enhanced LPS induced phosphorylation of p38 MAPK and [ERK] in DC , and inhibitors of p38 MAPK , , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation EPHB2 MAP2K4 18454176 1951543 Moreover , GATA-6 was phosphorylated at serine residues by *activated* [ERK] , which increased GATA-6 DNA binding , correlating with suppression of the Nox1 promoter activity by an MEK inhibitor PD98059 . Positive_regulation EPHB2 MAP2K4 18632602 1937016 A selective inhibitor , AZD6244 , *inhibits* mutant induced [ERK] activity in 293T cells and growth of mutant bearing Ba/F3 cells . Positive_regulation EPHB2 MAP2K4 18656513 1972853 was *required* for phosphorylation of [ERK] and CREB , but not Akt , whereas G ( 0 ) /G ( i ) -proteins were necessary for phosphorylation of Akt and CREB , and cGMP was necessary for Akt phosphorylation . Positive_regulation EPHB2 MAP2K4 18695640 1973871 ROCK inhibition also reduced 5-HT stimulated proliferation by suppressing *stimulated* [ERK] phosphorylation . Positive_regulation EPHB2 MAP2K4 18711316 2006001 Moreover , pretreatment with DIDS ( Cl- channel blockers ) but not LY294002 ( PI3K inhibitors ) completely abolished the LDL induced upregulation of Egr-1 to the same extent as PD98059 ( inhibitors to *inhibit* [Erk] ) , as judged by Western blot and luciferase reporter assays . Positive_regulation EPHB2 MAP2K4 18771726 1980334 We demonstrated here , that PTPIP51 could regulate ERK activity on Raf level , since inhibitor and dominant negative Raf-1 but not Ras could *inhibit* the [ERK] activation induced by PTPIP51 . Positive_regulation EPHB2 MAP2K4 19098317 2047662 PI3K inhibitor ( Ly294002 ) significantly decreased pAkt activity and HIF-1alpha and VEGF expression in vivo and in vitro , whereas inhibitor ( PD98059 ) *reduced* [ERK] phosphorylation and the expression of VEGF but had no effect on HIF-1alpha . Positive_regulation EPHB2 MAP2K4 19176641 2061150 U-0126 , the ( MAPK kinase ) inhibitors *blocked* [ERK] activation and cell proliferation induced by diazoxide . Positive_regulation EPHB2 MAP2K4 19241161 2086558 Furthermore , we also demonstrated here that Zn2+ stimulates the phosphorylation of [ERK] and that the pathway inhibitor , U0126 , *suppressed* Zn2+ induced PUMA expression . Positive_regulation EPHB2 MAP2K4 19319189 2052421 multiprotein complex to *promote* sustained [ERK] activation and regulate H-Ras dependent neuritogenesis . Positive_regulation EPHB2 MAP2K4 19703440 2158081 Furthermore , [ERK] activation and angiogenic sprouting in response to NMB are significantly *blocked* by the inhibitor . Positive_regulation EPHB2 MAP2K4 20526801 2320142 Furthermore , we also demonstrate that either chemical inhibition of ( U0126 ) or stable downregulation of PDGFRß by shRNA similarly results in the *loss* of PDGF induced [ERK] phosphorylation and abolishes Rac1/Pak1 activation and cell migration in response to PDGF . Positive_regulation EPHB2 MAP2K4 20542106 2301955 Activation of these pathways by ATP seemed to be independent , since LY294002 and U0126 , inhibitors of PI3K and , did not *block* the activation of [ERK] and AKT , respectively , although each compound blocked its respective target . Positive_regulation EPHB2 MAP2K4 20668238 2305305 inhibitors *inhibit* [ERK] phosphorylation in all normal and tumor cells , whereas PLX4032 inhibits ERK signaling only in tumor cells expressing BRAF ( V600E ) . Positive_regulation EPHB2 MAP2K4 20668435 2317106 In addition , DHA caused AKT and [ERK] activation in a time dependent manner , and the DHA induced HO-1 upregulation could be *attenuated* by PI-3 kinase/AKT and inhibitors . Positive_regulation EPHB2 MAP2K4 21088259 2389774 These cells displayed high levels of ERK activation , that is , at least in part , independent of the conventional RAF/MEK/ERK pathway , as MEK activation was low and inhibition of did not significantly *block* activation of [ERK] . Positive_regulation EPHB2 MAP2K4 21106560 2395798 Experiments carried out with pharmacological inhibitors show that *dependent* [ERK] and phosphatidylinositol 3-kinase dependent AKT pathways are positive regulators of the lectin- and insulin mediated adipogenic differentiation , while stress activated kinase/c-jun N-terminal kinase pathway acts as a negative one . Positive_regulation EPHB2 MAP2K4 21336309 2399445 Expression of un-SUMOylatable *enhanced* [ERK] activation , cell differentiation , proliferation and malignant transformation by oncogenic ErbB2 or Raf , but not by active Ras . Positive_regulation EPHB2 MAP2K4 21665194 2446303 inhibitors and alpha7-nicotinic acetylcholine receptor ( a7nAChR ) antagonist *blocked* the neurite outgrowth and the activation of [ERK] induced by B12H . Positive_regulation EPHB2 MAP2K4 22087839 2514175 Therefore , inhibition of mediated [ERK] *activation* is very appealing in cancer therapy . Positive_regulation EPHB2 MAP2K4 22087839 2514182 Inhibition of mediated [ERK] *activation* , therefore , compromises checkpoint activation . Positive_regulation EPHB2 MAP2K4 22278923 2551572 By contrast , in human embryos , inhibition of MEK did not significantly alter epiblast or hypoblast precursor numbers despite the ability of the inhibitor to potently *inhibit* [ERK] phosphorylation in human ES cells . Positive_regulation EPHB2 MAP2K4 22328534 2642854 PD98059 , inhibitor , or U0126 , [ERK] *inhibitor* , reduced SNU668 cell migration accompanying an increase in p-GSK-3a , ß-catenin and E-cadherin . Positive_regulation EPHB2 MAP2K4 22556409 2614117 [ERK] activation was *prevented* by inhibitors and was associated with concurrent stimulation of RAF kinase activity but not RAS activation . Positive_regulation EPHB2 MAP2K4 22740332 2715441 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Positive_regulation EPHB2 MAP2K4 22785235 2691766 TRH induced CRE promoter was inhibited by mitogen activated protein [kinase/ERK] kinase ( MEK ) inhibitor and was *increased* by overexpression of . Positive_regulation EPHB2 MAP2K4 22892241 2666330 However , unlike ( V600E ) Braf , [Mek/Erk] pathway activation was mediated by both Craf and Braf , and ATP-competitive RAF inhibitors *induced* paradoxical pathway activation . Positive_regulation EPHB2 MAP2K4 22906417 2678032 Furthermore , post-EMT cells exhibited decreased basal Raf and [Erk] phosphorylation , and in comparison to pre-EMT cells , their proliferation was poorly *inhibited* by a inhibitor . Positive_regulation EPHB2 MAP2K4 23102728 2729192 inhibitors , either AZD6244 or CI1040 , *inhibited* [ERK] phosphorylation and sensitized gefitinib induced cytotoxicity in PC-9/gef cells . Positive_regulation EPHB2 MAP2K4 23210697 2736382 Complete [ERK] *activation* by the kinase requires dual phosphorylation at T and Y within the activation motif TEY . Positive_regulation EPHB2 MAP2K4 23360980 2758733 Consequently , coexpression of wildtype C-Raf and was *sufficient* for full and constitutive activation of [ERK] . Positive_regulation EPHB2 MAP2K4 23499828 2827634 H2S stimulated T cell activation by potentiating *dependent* [ERK] phosphorylation , and thrombospondin-1 inhibited this signaling in a CD47 dependent manner . Positive_regulation EPHB2 MAP2K4 23806683 2820635 [ERK] *activation* by the over-expression of constitutively active increased protein levels and enhanced the stability of SIRT2 . Positive_regulation EPHB2 MAP2K4 24530412 2924279 It is noteworthy that a tyrosine kinase receptor inhibitor , K252a , an inhibitor ( U0126 ) , and a PI3Kinase-Akt inhibitor ( LY294002 ) remarkably *attenuated* TrkB , [ERK] , and Akt phosphorylation as well as increase of OPN mRNA expression in the HCEM cells , respectively . Positive_regulation EPHB2 MAP2K4 24746704 2936460 Here , we found that inhibitors *suppress* [ERK] signaling more potently in BRAF ( V600E ) , than in KRAS mutant tumors . Positive_regulation EPHB2 MAP2K4 8226933 235292 *Activation* of extracellular signal regulated kinase ( [ERK] ) or mitogen activated protein kinase by ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation EPHB2 MAP2K4 8552085 347156 Expression of a dominant interfering mutant , in which lysine 97 was replaced with arginine ( MEK/K97R ) , *resulted* in an inhibition of insulin stimulated SOS and [ERK] phosphorylation , whereas expression of a constitutively active MEK mutant , in which serines 218 and 222 were replaced with glutamic acid ( MEK/EE ) , induced basal phosphorylation of both SOS and ERK . Positive_regulation EPHB2 MAP2K4 9390997 467675 Furthermore , overexpression of a kinase-inactive mutant *inhibited* phorbol ester stimulation of APP secretion and activation of [ERK] in human embryonic kidney cell lines . Positive_regulation EPHB2 MAP2K4 9442025 482989 Arsenite induced [ERK] activation is *mediated* by Ras , Raf , and but appears to be independent of de novo protein synthesis . Positive_regulation EPHB2 MAP2K4 9687508 522239 Consistently , *induced* [ERK] activation in PC12 cells induces c-Jun expression , while JNK signalling does not . Positive_regulation EPHB2 MAP2K4 9826736 550737 Inhibition of ( proximal activator of Erk ) also *blocked* stimulation of [Erk] and adhesion by formylmethionyl-leucyl-phenylalanineand arachidonic acid . Positive_regulation EPHB2 MAP2K4 9864179 582701 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of [ERK] , but not p38 MAPK , induced by G-CSF , GM-CSF , or TNF . Positive_regulation EPHB2 MAP2K5 10383890 624671 The inhibitor , PD 098059 *inhibited* EGF stimulated proliferation and [ERK] activity in a parallel , dose dependent manner showing that ERK activation is at least permissive for the proliferative response to EGF . Positive_regulation EPHB2 MAP2K5 10402467 628942 Ras and were *necessary* and sufficient for uPA induced [ERK] activation and stimulation of cellular migration , as demonstrated in experiments with dominant negative and constitutively active mutants of these signaling proteins . Positive_regulation EPHB2 MAP2K5 10523856 653796 The inhibitor PD 098059 , as well as the PKC inhibitors , completely *blocked* TPA mediated [ERK] activation . Positive_regulation EPHB2 MAP2K5 10688043 669958 Inhibition of EGF- and LPA- induced [ERK] activation with the EGF receptor inhibitor , AG1478 , or the inhibitor , PD98059 , *attenuated* their proliferative effects . Positive_regulation EPHB2 MAP2K5 10700616 672426 We have therefore hypothesized that [ERK] *activation* through is required for optimal induction of neurite growth by these proteins . Positive_regulation EPHB2 MAP2K5 10783161 688174 Sur-8 expression enhances Ras- or EGF induced Raf and ERK activation but has no effect on [ERK] activation *induced* by active Raf or . Positive_regulation EPHB2 MAP2K5 10888263 710244 However , PD098059 mediated inhibition of *dependent* stimulation of [ERK] did not alter the hypertrophic response of either agonist . Positive_regulation EPHB2 MAP2K5 10965502 727991 17 beta-oestradiol increased B-Raf activity and *dependent* [ERK] phosphorylation in explants of wild-type and ERKO cerebral cortex . Positive_regulation EPHB2 MAP2K5 10996792 733910 As in proliferating cells , [ERK] activation during G0 *required* the MAPkinase kinase and was partially dependent on cell adhesion . Positive_regulation EPHB2 MAP2K5 11005808 752394 A inhibitor , PD98059 , *inhibited* heat shock [ERK] MAPK activation by > 75 % . Positive_regulation EPHB2 MAP2K5 11311983 805182 This provides evidence for a novel pathway linking striatal kainate receptors to [ERK] *activation* via PI3 kinase and . Positive_regulation EPHB2 MAP2K5 11359871 816502 6-OHDA elicited ERK phosphorylation was blocked by PD98059 , an inhibitor of the upstream ( MEK ) that phosphorylates and *activates* [ERK] . Positive_regulation EPHB2 MAP2K5 11413312 828902 The inhibitors PD98059 and U0126 *blocked* [Erk] activation and release of IL-8 following infection with Ad7 . Positive_regulation EPHB2 MAP2K5 11418608 843268 VPA induced *activation* of [ERK] was blocked by the mitogen activated protein kinase/ERK kinase inhibitor PD098059 and dominant negative Ras and Raf mutants but not by dominant negative stress activated protein kinase/ERK kinase and 6 mutants . Positive_regulation EPHB2 MAP2K5 11546664 856572 The mitogen activated protein kinase (MAPK) kinase ( ) inhibitors , PD-98059 and U-0126 , *blocked* IL-1 alpha induced [ERK] activation and partially attenuated cPLA(2)alpha phosphorylation and PGI ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation EPHB2 MAP2K5 11564685 863262 The specific Mek inhibitor , PD98059 , blocked the activation of the Erks by ACTH and basic fibroblast growth factor , indicating that is the upstream *activator* of [Erk] . Positive_regulation EPHB2 MAP2K5 11641250 872080 Stimulation of [Erk] activity was *due* to activation of Ras , Raf-1 , and ( MAPK kinase ) . Positive_regulation EPHB2 MAP2K5 11804669 903327 PD 98059 , a inhibitor , and glutathione , an anti-thiol-oxidant , not only *blocked* Cpd 5-induced [ERK] phosphorylation , but also antagonized the activation of CPP-32 , the altered Bcl-2/Bax expression , and DNA fragmentation . Positive_regulation EPHB2 MAP2K5 11812003 907192 The inhibitors , U0126 and PD-98059 , dose-dependently *inhibited* the [ERK] activity stimulated by EGF . Positive_regulation EPHB2 MAP2K5 11841924 912280 PMA also phosphorylated MEK and [ERK] , and PMA induced GATA-4 phosphorylation was *blocked* by an inhibitor , PD98059 , suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway . Positive_regulation EPHB2 MAP2K5 12055096 951683 The inhibitors PD-98059 and U-0126 *blocked* [ERK] activation mediated by diazoxide . Positive_regulation EPHB2 MAP2K5 12070086 955772 Addition of inhibitor in the culture medium *prevented* [ERK] activation and metamorphosis . Positive_regulation EPHB2 MAP2K5 12364324 1019138 GLP1 stimulated activation of [Erk] is *blocked* by inhibitors of , but GLP1 does not induce the activation of A-Raf , B-Raf , C-Raf , or Ras . Positive_regulation EPHB2 MAP2K5 12493768 1056684 Consistent with this premise , FSH stimulated [ERK] activation is *inhibited* by the cell-permeable protein kinase A-specific inhibitor peptide Myr-PKI as well as by inhibitors of , Src , a Ca ( 2+ ) channel blocker , and chelation of extracellular Ca ( 2+ ) . Positive_regulation EPHB2 MAP2K5 12506070 1038325 A specific inhibitor of *blocked* the TNFalpha induction of the MMPs and TIMPs and the phosphorylation of [Erk] . Positive_regulation EPHB2 MAP2K5 12514175 1063805 Low K ( + ) *induced* delayed and persistent [ERK] activation , which was blocked by inhibitors or GDF-15 . Positive_regulation EPHB2 MAP2K5 12588763 1059636 inhibitors U0126 and PD98059 *blocked* both [ERK] activation and the increase in TF mRNA . Positive_regulation EPHB2 MAP2K5 12657694 1073288 [ERK] activation was *blocked* by inhibiting , the upstream activator of ERK . Positive_regulation EPHB2 MAP2K5 12664642 1030353 Inhibition of ( proximal activator of Erk ) also *blocked* stimulation of [Erk] and neutrophil aggregation by FMLP and arachidonic acid . Positive_regulation EPHB2 MAP2K5 12675684 1076701 In contrast , the *activation* of [ERK] by constitutively active forms of was not inhibited , suggesting that the actions of SptP were mediated by Raf-1 . Positive_regulation EPHB2 MAP2K5 12686598 1078127 In unstimulated cells , tropomyosin-1 was found diffuse in the cells , whereas it quickly colocalized with actin and stress fibers upon *stimulation* of [ERK] by H ( 2 ) O ( 2 ) or by expression of ( CA ) . Positive_regulation EPHB2 MAP2K5 12706116 1082486 In PC12 cells , NGF and EGF induce a rapid translocation of [GFP-Erk] that *requires* Ras and . Positive_regulation EPHB2 MAP2K5 12736249 1107190 We observed that growth stimulation was associated with stimulation of ERK1/2 phosphorylation (ERK-P) , and both growth and [ERK-P] could be *blocked* by the inhibitor ( U0126 , 100 nm ) . Positive_regulation EPHB2 MAP2K5 12738796 1107267 Surprisingly , this induction of phosphorylation does not *result* in [ERK] activation in vivo . Positive_regulation EPHB2 MAP2K5 12758056 1090985 Inhibition of *induced* [ERK] phosphorylation had no effect on adipogenesis but prevented this TCDD suppression . Positive_regulation EPHB2 MAP2K5 12850584 1109566 Abeta induced [ERK] phosphorylation was completely *blocked* by the inhibitors , while Abeta induced promotion of extracellular L-glutamate clearance was enhanced by the presence of the MEK inhibitors . Positive_regulation EPHB2 MAP2K5 14514659 1185728 A low level ( 2 micro M ) of arsenite stimulated extracellular signal regulated kinase ( ERK ) signaling pathway and enhanced cell proliferation , and this arsenite induced [ERK] activity was *blocked* by inhibitor , PD98059 . Positive_regulation EPHB2 MAP2K5 14517212 1164977 The inhibitors PD 98059 and U0126 *blocked* [ERK] phosphorylation , as did the adenylate cyclase activator forskolin . Positive_regulation EPHB2 MAP2K5 14555984 1153215 In androgen depleted condition , PD98059 , an inhibitor , could efficiently *block* not only the activation of [ERK] , but also the acquisition of the NE-like morphology and the elevation of NSE in C-33 LNCaP cells . Positive_regulation EPHB2 MAP2K5 14563359 1154809 Experiments based on inhibitors of specific signaling pathways , such as manumycin A , toxin A , U0126 , PD98059 and wortmannin revealed that Ras , and PI-3K are *involved* in the activation of [ERK] . Positive_regulation EPHB2 MAP2K5 14688282 1211512 However , PD98059 , a specific inhibitor of ( MEK1 ) , *inhibited* [ERK] activation by TGF-beta(1) , and consequently attenuated TGF-beta(1) enhancement of its own mRNA expression in PSCs . Positive_regulation EPHB2 MAP2K5 14719071 1197690 In cisplatin-resistant UM-SCC-23 in culture , which we have established , the protein levels of Ras , Raf-1 and were drastically elevated compared to parent UM-SCC-23 , and [ERK] and Akt signals were constitutively *activated* . Positive_regulation EPHB2 MAP2K5 15159408 1273323 Use of U0126 revealed that palytoxin *requires* the ERK kinase to stimulate [ERK] activity , although palytoxin did not activate MEK . Positive_regulation EPHB2 MAP2K5 15174091 1254268 Conversely , treatment with U0126 , a potent inhibitor of mediated [ERK] *activation* , prevented FAK phosphorylation at Ser-910 induced by PDGF but did not interfere with PDGF induced FAK phosphorylation at Tyr-397 . Positive_regulation EPHB2 MAP2K5 15304546 1322383 Furthermore , *activation* of [ERK/MAPK] by the coexpression of constitutively active predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation EPHB2 MAP2K5 15537634 1360474 [ERK] activation was *prevented* by inhibitors that had no effect on PYK2 . Positive_regulation EPHB2 MAP2K5 15607817 1357029 Furthermore , U0126 and LY294002 , which respectively inhibit *induced* [ERK] phosphorylation and PI3 kinase mediated Akt phosphorylation had distinct effects on C3a induced responses . Positive_regulation EPHB2 MAP2K5 15652235 1364134 PD98059 , a inhibitor , and BAY 11-8702 , an I kappa B-alpha inhibitor , *reduced* [ERK] and NF-kappa B cascade activation , respectively , with little effect on PKC phosphorylation . Positive_regulation EPHB2 MAP2K5 15674440 1350827 [ERK] phosphorylation was *reduced* by a inhibitor , PD98059 . Positive_regulation EPHB2 MAP2K5 15691837 1388550 In its central portion *activates* [ERK] , leading to increased collagen expression . Positive_regulation EPHB2 MAP2K5 15749869 1379691 We found that prior stimulation of primary murine B cells with CD40L markedly enhanced the level of ERK and JNK ( but not p38 MAPK ) phosphorylation produced by subsequently added anti-Ig Ab , and much , but not all , of this enhancement was independent of PI3K and phospholipase C . CD40L treatment similarly enhanced BCR induced MAPK kinase ( MEK ) phosphorylation , and was *required* for enhancement of [ERK] . Positive_regulation EPHB2 MAP2K5 15750341 1379873 These findings indicate that [ERK] phosphorylation in response to glycated LDL *involves* the activation of PKC , PLC , and , but is independent of intracellular Ca2+ . Positive_regulation EPHB2 MAP2K5 15801908 1432343 The ( MAPK/ERK kinase ) inhibitors PD98059 and U0126 *blocked* IGF-I stimulated [ERK] phosphorylation but did not block the phosphorylation of Akt and did not decrease proteoglycan synthesis . Positive_regulation EPHB2 MAP2K5 15843032 1398309 Treatment of myoblasts with LIF induced phosphorylation of [ERK] , and the LIF induced inhibitory effect on myogenesis was *blocked* by pretreatment with U0126 , a specific inhibitor , and transient transfection with dominant negative ( DN ) -MEK1 . Positive_regulation EPHB2 MAP2K5 15843535 1398466 As in the classical pathway , BCR induced [ERK] activation in the new , PI3K independent pathway *required* and was reflected in c-Raf . Positive_regulation EPHB2 MAP2K5 15855657 1439589 Activation of ERK was attenuated by drugs that disassemble the actin cytoskeleton ( cytochalasin D , latrunculin B ) , and these compounds interfered with the *activation* of [ERK] by ( MEK ) . Positive_regulation EPHB2 MAP2K5 16189274 1507734 In MET positive DLBCL cells , HGF induces dependent *activation* of [ERK] and PI3K dependent phosphorylation of PKB , GSK3 , and FOXO3a . Positive_regulation EPHB2 MAP2K5 16360949 1504583 The phospho-ERK and phospho-MEK profiles were similar , suggesting that [ERK] phosphorylation is *regulated* by . Positive_regulation EPHB2 MAP2K5 16877565 1638800 However , inhibitors of Raf-1 and or a dominant negative ERK mutant *blocked* FKN induced [ERK] , but not Akt and eNOS , phosphorylation . Positive_regulation EPHB2 MAP2K5 16983658 1633619 In parallel , farnesyltransferase and inhibitors *blocked* [ERK] phosphorylation and neuroprotective effect of NAC . Positive_regulation EPHB2 MAP2K5 17130674 1661370 PD98059 , a ( mitogen activated protein kinase kinase ) inhibitor , and BAPTA-AM [ O , O'-bis ( 2-aminophenyl ) ethyleneglycol-N , N,N ' , N'-tetraacetic acid , tetraacetoxymethyl ester ] , an intracellular Ca ( 2+ ) chelator , *reduced* UTP induced [ERK] phosphorylation and IL-6 mRNA expression . Positive_regulation EPHB2 MAP2K5 17182785 1662667 Specifically , inhibition of GSK-3beta led to increased [ERK] phosphorylation , and inhibition of completely *blocked* the effects of GSK-3beta inhibition on dendrite initiation and growth . Positive_regulation EPHB2 MAP2K5 17189385 1662771 In addition , inhibitor ( PD98059 ) *reduced* the interaction between p65 and [ERK] . Positive_regulation EPHB2 MAP2K5 17337598 1765821 A pharmacological inhibitor of activity *inhibits* LPA stimulated WT Hic-5 cell migration and [ERK] phosphorylation , suggesting Hic-5 enhances migration via MEK activation of ERK . Positive_regulation EPHB2 MAP2K5 17379261 1720779 FTY720P augmented [ERK] phosphorylation in cortical cultures prepared from embryonic day 18 rat brains and was *blocked* by an inhibitor or by pertussis toxin . Positive_regulation EPHB2 MAP2K5 17526574 1784070 , once phosphorylated by Raf , *triggers* [Erk] phosphorylation , which in turn induces dissociation of Raf-inaccessible Mek-Erk heterodimers , and thus further amplifies Mek phosphorylation . Positive_regulation EPHB2 MAP2K5 18068691 1853772 This mechanism was found to be specific to etorphine , as activation of [ERK] by the micro-opioid receptor ( MOR ) agonist DAMGO ( [ D-Ala ( 2 ) , N-Me-Phe ( 4 ) , Gly ( 5 ) -ol ] enkephalin ) was *mediated* by in these cells , suggesting that etorphine and DAMGO activate distinct , ligand-specific , conformations of MOR . Positive_regulation EPHB2 MAP2K5 18401006 1925754 CyaA enhanced LPS induced phosphorylation of p38 MAPK and [ERK] in DC , and inhibitors of p38 MAPK , , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation EPHB2 MAP2K5 18454176 1951544 Moreover , GATA-6 was phosphorylated at serine residues by *activated* [ERK] , which increased GATA-6 DNA binding , correlating with suppression of the Nox1 promoter activity by an MEK inhibitor PD98059 . Positive_regulation EPHB2 MAP2K5 18632602 1937017 A selective inhibitor , AZD6244 , *inhibits* mutant induced [ERK] activity in 293T cells and growth of mutant bearing Ba/F3 cells . Positive_regulation EPHB2 MAP2K5 18656513 1972854 was *required* for phosphorylation of [ERK] and CREB , but not Akt , whereas G ( 0 ) /G ( i ) -proteins were necessary for phosphorylation of Akt and CREB , and cGMP was necessary for Akt phosphorylation . Positive_regulation EPHB2 MAP2K5 18695640 1973872 ROCK inhibition also reduced 5-HT stimulated proliferation by suppressing *stimulated* [ERK] phosphorylation . Positive_regulation EPHB2 MAP2K5 18711316 2006002 Moreover , pretreatment with DIDS ( Cl- channel blockers ) but not LY294002 ( PI3K inhibitors ) completely abolished the LDL induced upregulation of Egr-1 to the same extent as PD98059 ( inhibitors to *inhibit* [Erk] ) , as judged by Western blot and luciferase reporter assays . Positive_regulation EPHB2 MAP2K5 18771726 1980335 We demonstrated here , that PTPIP51 could regulate ERK activity on Raf level , since inhibitor and dominant negative Raf-1 but not Ras could *inhibit* the [ERK] activation induced by PTPIP51 . Positive_regulation EPHB2 MAP2K5 19098317 2047663 PI3K inhibitor ( Ly294002 ) significantly decreased pAkt activity and HIF-1alpha and VEGF expression in vivo and in vitro , whereas inhibitor ( PD98059 ) *reduced* [ERK] phosphorylation and the expression of VEGF but had no effect on HIF-1alpha . Positive_regulation EPHB2 MAP2K5 19176641 2061151 U-0126 , the ( MAPK kinase ) inhibitors *blocked* [ERK] activation and cell proliferation induced by diazoxide . Positive_regulation EPHB2 MAP2K5 19241161 2086559 Furthermore , we also demonstrated here that Zn2+ stimulates the phosphorylation of [ERK] and that the pathway inhibitor , U0126 , *suppressed* Zn2+ induced PUMA expression . Positive_regulation EPHB2 MAP2K5 19319189 2052422 multiprotein complex to *promote* sustained [ERK] activation and regulate H-Ras dependent neuritogenesis . Positive_regulation EPHB2 MAP2K5 19703440 2158082 Furthermore , [ERK] activation and angiogenic sprouting in response to NMB are significantly *blocked* by the inhibitor . Positive_regulation EPHB2 MAP2K5 20526801 2320143 Furthermore , we also demonstrate that either chemical inhibition of ( U0126 ) or stable downregulation of PDGFRß by shRNA similarly *results* in the loss of PDGF induced [ERK] phosphorylation and abolishes Rac1/Pak1 activation and cell migration in response to PDGF . Positive_regulation EPHB2 MAP2K5 20542106 2301956 Activation of these pathways by ATP seemed to be independent , since LY294002 and U0126 , inhibitors of PI3K and , did not *block* the activation of [ERK] and AKT , respectively , although each compound blocked its respective target . Positive_regulation EPHB2 MAP2K5 20668238 2305306 inhibitors *inhibit* [ERK] phosphorylation in all normal and tumor cells , whereas PLX4032 inhibits ERK signaling only in tumor cells expressing BRAF ( V600E ) . Positive_regulation EPHB2 MAP2K5 20668435 2317107 In addition , DHA caused AKT and [ERK] activation in a time dependent manner , and the DHA induced HO-1 upregulation could be *attenuated* by PI-3 kinase/AKT and inhibitors . Positive_regulation EPHB2 MAP2K5 21088259 2389775 These cells displayed high levels of ERK activation , that is , at least in part , independent of the conventional RAF/MEK/ERK pathway , as MEK activation was low and inhibition of did not significantly *block* activation of [ERK] . Positive_regulation EPHB2 MAP2K5 21106560 2395799 Experiments carried out with pharmacological inhibitors show that *dependent* [ERK] and phosphatidylinositol 3-kinase dependent AKT pathways are positive regulators of the lectin- and insulin mediated adipogenic differentiation , while stress activated kinase/c-jun N-terminal kinase pathway acts as a negative one . Positive_regulation EPHB2 MAP2K5 21336309 2399446 Expression of un-SUMOylatable *enhanced* [ERK] activation , cell differentiation , proliferation and malignant transformation by oncogenic ErbB2 or Raf , but not by active Ras . Positive_regulation EPHB2 MAP2K5 21665194 2446304 inhibitors and alpha7-nicotinic acetylcholine receptor ( a7nAChR ) antagonist *blocked* the neurite outgrowth and the activation of [ERK] induced by B12H . Positive_regulation EPHB2 MAP2K5 22087839 2514176 Therefore , inhibition of mediated [ERK] *activation* is very appealing in cancer therapy . Positive_regulation EPHB2 MAP2K5 22087839 2514183 Inhibition of mediated [ERK] *activation* , therefore , compromises checkpoint activation . Positive_regulation EPHB2 MAP2K5 22278923 2551573 By contrast , in human embryos , inhibition of MEK did not significantly alter epiblast or hypoblast precursor numbers despite the ability of the inhibitor to potently *inhibit* [ERK] phosphorylation in human ES cells . Positive_regulation EPHB2 MAP2K5 22328534 2642855 PD98059 , inhibitor , or U0126 , [ERK] *inhibitor* , reduced SNU668 cell migration accompanying an increase in p-GSK-3a , ß-catenin and E-cadherin . Positive_regulation EPHB2 MAP2K5 22556409 2614118 [ERK] activation was *prevented* by inhibitors and was associated with concurrent stimulation of RAF kinase activity but not RAS activation . Positive_regulation EPHB2 MAP2K5 22740332 2715442 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Positive_regulation EPHB2 MAP2K5 22785235 2691767 TRH induced CRE promoter was inhibited by mitogen activated protein [kinase/ERK] kinase ( MEK ) inhibitor and was *increased* by overexpression of . Positive_regulation EPHB2 MAP2K5 22892241 2666331 However , unlike ( V600E ) Braf , pathway activation was mediated by both Craf and Braf , and ATP-competitive RAF inhibitors *induced* paradoxical [Mek/Erk] pathway activation . Positive_regulation EPHB2 MAP2K5 22906417 2678033 Furthermore , post-EMT cells exhibited decreased basal Raf and [Erk] phosphorylation , and in comparison to pre-EMT cells , their proliferation was poorly *inhibited* by a inhibitor . Positive_regulation EPHB2 MAP2K5 23102728 2729193 inhibitors , either AZD6244 or CI1040 , *inhibited* [ERK] phosphorylation and sensitized gefitinib induced cytotoxicity in PC-9/gef cells . Positive_regulation EPHB2 MAP2K5 23210697 2736383 Complete [ERK] *activation* by the kinase requires dual phosphorylation at T and Y within the activation motif TEY . Positive_regulation EPHB2 MAP2K5 23360980 2758734 Consequently , coexpression of wildtype C-Raf and was *sufficient* for full and constitutive activation of [ERK] . Positive_regulation EPHB2 MAP2K5 23499828 2827635 H2S stimulated T cell activation by potentiating *dependent* [ERK] phosphorylation , and thrombospondin-1 inhibited this signaling in a CD47 dependent manner . Positive_regulation EPHB2 MAP2K5 23806683 2820636 [ERK] *activation* by the over-expression of constitutively active increased protein levels and enhanced the stability of SIRT2 . Positive_regulation EPHB2 MAP2K5 24530412 2924280 It is noteworthy that a tyrosine kinase receptor inhibitor , K252a , an inhibitor ( U0126 ) , and a PI3Kinase-Akt inhibitor ( LY294002 ) remarkably *attenuated* TrkB , [ERK] , and Akt phosphorylation as well as increase of OPN mRNA expression in the HCEM cells , respectively . Positive_regulation EPHB2 MAP2K5 24746704 2936461 Here , we found that inhibitors *suppress* [ERK] signaling more potently in BRAF ( V600E ) , than in KRAS mutant tumors . Positive_regulation EPHB2 MAP2K5 8226933 235293 *Activation* of extracellular signal regulated kinase ( [ERK] ) or mitogen activated protein kinase by ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation EPHB2 MAP2K5 8552085 347157 Expression of a dominant interfering mutant , in which lysine 97 was replaced with arginine ( MEK/K97R ) , *resulted* in an inhibition of insulin stimulated SOS and [ERK] phosphorylation , whereas expression of a constitutively active MEK mutant , in which serines 218 and 222 were replaced with glutamic acid ( MEK/EE ) , induced basal phosphorylation of both SOS and ERK . Positive_regulation EPHB2 MAP2K5 9390997 467676 Furthermore , overexpression of a kinase-inactive mutant *inhibited* phorbol ester stimulation of APP secretion and activation of [ERK] in human embryonic kidney cell lines . Positive_regulation EPHB2 MAP2K5 9442025 482990 Arsenite induced [ERK] activation is *mediated* by Ras , Raf , and but appears to be independent of de novo protein synthesis . Positive_regulation EPHB2 MAP2K5 9687508 522240 Consistently , induced [ERK] *activation* in PC12 cells induces c-Jun expression , while JNK signalling does not . Positive_regulation EPHB2 MAP2K5 9826736 550738 Inhibition of ( proximal activator of Erk ) also *blocked* stimulation of [Erk] and adhesion by formylmethionyl-leucyl-phenylalanineand arachidonic acid . Positive_regulation EPHB2 MAP2K5 9864179 582702 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of [ERK] , but not p38 MAPK , induced by G-CSF , GM-CSF , or TNF . Positive_regulation EPHB2 MAP2K6 10383890 624672 The inhibitor , PD 098059 *inhibited* EGF stimulated proliferation and [ERK] activity in a parallel , dose dependent manner showing that ERK activation is at least permissive for the proliferative response to EGF . Positive_regulation EPHB2 MAP2K6 10402467 628943 Ras and were *necessary* and sufficient for uPA induced [ERK] activation and stimulation of cellular migration , as demonstrated in experiments with dominant negative and constitutively active mutants of these signaling proteins . Positive_regulation EPHB2 MAP2K6 10523856 653797 The inhibitor PD 098059 , as well as the PKC inhibitors , completely *blocked* TPA mediated [ERK] activation . Positive_regulation EPHB2 MAP2K6 10688043 669959 Inhibition of EGF- and LPA- induced [ERK] activation with the EGF receptor inhibitor , AG1478 , or the inhibitor , PD98059 , *attenuated* their proliferative effects . Positive_regulation EPHB2 MAP2K6 10700616 672427 We have therefore hypothesized that [ERK] *activation* through is required for optimal induction of neurite growth by these proteins . Positive_regulation EPHB2 MAP2K6 10783161 688175 Sur-8 expression enhances Ras- or EGF induced Raf and ERK activation but has no effect on [ERK] activation *induced* by active Raf or . Positive_regulation EPHB2 MAP2K6 10888263 710245 However , PD098059 mediated inhibition of *dependent* stimulation of [ERK] did not alter the hypertrophic response of either agonist . Positive_regulation EPHB2 MAP2K6 10965502 727992 17 beta-oestradiol increased B-Raf activity and *dependent* [ERK] phosphorylation in explants of wild-type and ERKO cerebral cortex . Positive_regulation EPHB2 MAP2K6 10996792 733911 As in proliferating cells , [ERK] activation during G0 *required* the MAPkinase kinase and was partially dependent on cell adhesion . Positive_regulation EPHB2 MAP2K6 11005808 752395 A inhibitor , PD98059 , *inhibited* heat shock [ERK] MAPK activation by > 75 % . Positive_regulation EPHB2 MAP2K6 11311983 805183 This provides evidence for a novel pathway linking striatal kainate receptors to [ERK] *activation* via PI3 kinase and . Positive_regulation EPHB2 MAP2K6 11359871 816503 6-OHDA elicited ERK phosphorylation was blocked by PD98059 , an inhibitor of the upstream ( MEK ) that phosphorylates and *activates* [ERK] . Positive_regulation EPHB2 MAP2K6 11413312 828903 The inhibitors PD98059 and U0126 *blocked* [Erk] activation and release of IL-8 following infection with Ad7 . Positive_regulation EPHB2 MAP2K6 11418608 843269 VPA induced *activation* of [ERK] was blocked by the mitogen activated protein kinase/ERK kinase inhibitor PD098059 and dominant negative Ras and Raf mutants but not by dominant negative stress activated protein kinase/ERK kinase and 6 mutants . Positive_regulation EPHB2 MAP2K6 11546664 856573 The mitogen activated protein kinase (MAPK) kinase ( ) inhibitors , PD-98059 and U-0126 , *blocked* IL-1 alpha induced [ERK] activation and partially attenuated cPLA(2)alpha phosphorylation and PGI ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation EPHB2 MAP2K6 11564685 863263 The specific Mek inhibitor , PD98059 , blocked the activation of the Erks by ACTH and basic fibroblast growth factor , indicating that is the upstream *activator* of [Erk] . Positive_regulation EPHB2 MAP2K6 11641250 872081 Stimulation of [Erk] activity was *due* to activation of Ras , Raf-1 , and ( MAPK kinase ) . Positive_regulation EPHB2 MAP2K6 11804669 903328 PD 98059 , a inhibitor , and glutathione , an anti-thiol-oxidant , not only *blocked* Cpd 5-induced [ERK] phosphorylation , but also antagonized the activation of CPP-32 , the altered Bcl-2/Bax expression , and DNA fragmentation . Positive_regulation EPHB2 MAP2K6 11812003 907193 The inhibitors , U0126 and PD-98059 , dose-dependently *inhibited* the [ERK] activity stimulated by EGF . Positive_regulation EPHB2 MAP2K6 11841924 912281 PMA also phosphorylated MEK and [ERK] , and PMA induced GATA-4 phosphorylation was *blocked* by an inhibitor , PD98059 , suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway . Positive_regulation EPHB2 MAP2K6 12055096 951684 The inhibitors PD-98059 and U-0126 *blocked* [ERK] activation mediated by diazoxide . Positive_regulation EPHB2 MAP2K6 12070086 955773 Addition of inhibitor in the culture medium *prevented* [ERK] activation and metamorphosis . Positive_regulation EPHB2 MAP2K6 12364324 1019139 GLP1 stimulated activation of [Erk] is *blocked* by inhibitors of , but GLP1 does not induce the activation of A-Raf , B-Raf , C-Raf , or Ras . Positive_regulation EPHB2 MAP2K6 12493768 1056685 Consistent with this premise , FSH stimulated [ERK] activation is *inhibited* by the cell-permeable protein kinase A-specific inhibitor peptide Myr-PKI as well as by inhibitors of , Src , a Ca ( 2+ ) channel blocker , and chelation of extracellular Ca ( 2+ ) . Positive_regulation EPHB2 MAP2K6 12506070 1038326 A specific inhibitor of *blocked* the TNFalpha induction of the MMPs and TIMPs and the phosphorylation of [Erk] . Positive_regulation EPHB2 MAP2K6 12514175 1063806 Low K ( + ) *induced* delayed and persistent [ERK] activation , which was blocked by inhibitors or GDF-15 . Positive_regulation EPHB2 MAP2K6 12588763 1059637 inhibitors U0126 and PD98059 *blocked* both [ERK] activation and the increase in TF mRNA . Positive_regulation EPHB2 MAP2K6 12657694 1073289 [ERK] activation was *blocked* by inhibiting , the upstream activator of ERK . Positive_regulation EPHB2 MAP2K6 12664642 1030354 Inhibition of ( proximal activator of Erk ) also *blocked* stimulation of [Erk] and neutrophil aggregation by FMLP and arachidonic acid . Positive_regulation EPHB2 MAP2K6 12675684 1076702 In contrast , the *activation* of [ERK] by constitutively active forms of was not inhibited , suggesting that the actions of SptP were mediated by Raf-1 . Positive_regulation EPHB2 MAP2K6 12686598 1078128 In unstimulated cells , tropomyosin-1 was found diffuse in the cells , whereas it quickly colocalized with actin and stress fibers upon *stimulation* of [ERK] by H ( 2 ) O ( 2 ) or by expression of ( CA ) . Positive_regulation EPHB2 MAP2K6 12706116 1082487 In PC12 cells , NGF and EGF induce a rapid translocation of [GFP-Erk] that *requires* Ras and . Positive_regulation EPHB2 MAP2K6 12736249 1107191 We observed that growth stimulation was associated with stimulation of ERK1/2 phosphorylation (ERK-P) , and both growth and [ERK-P] could be *blocked* by the inhibitor ( U0126 , 100 nm ) . Positive_regulation EPHB2 MAP2K6 12738796 1107268 Surprisingly , this induction of phosphorylation does not *result* in [ERK] activation in vivo . Positive_regulation EPHB2 MAP2K6 12758056 1090986 Inhibition of *induced* [ERK] phosphorylation had no effect on adipogenesis but prevented this TCDD suppression . Positive_regulation EPHB2 MAP2K6 12850584 1109567 Abeta induced [ERK] phosphorylation was completely *blocked* by the inhibitors , while Abeta induced promotion of extracellular L-glutamate clearance was enhanced by the presence of the MEK inhibitors . Positive_regulation EPHB2 MAP2K6 14514659 1185729 A low level ( 2 micro M ) of arsenite stimulated extracellular signal regulated kinase ( ERK ) signaling pathway and enhanced cell proliferation , and this arsenite induced [ERK] activity was *blocked* by inhibitor , PD98059 . Positive_regulation EPHB2 MAP2K6 14517212 1164978 The inhibitors PD 98059 and U0126 *blocked* [ERK] phosphorylation , as did the adenylate cyclase activator forskolin . Positive_regulation EPHB2 MAP2K6 14555984 1153216 In androgen depleted condition , PD98059 , an inhibitor , could efficiently *block* not only the activation of [ERK] , but also the acquisition of the NE-like morphology and the elevation of NSE in C-33 LNCaP cells . Positive_regulation EPHB2 MAP2K6 14563359 1154810 Experiments based on inhibitors of specific signaling pathways , such as manumycin A , toxin A , U0126 , PD98059 and wortmannin revealed that Ras , and PI-3K are *involved* in the activation of [ERK] . Positive_regulation EPHB2 MAP2K6 14688282 1211513 However , PD98059 , a specific inhibitor of ( MEK1 ) , *inhibited* [ERK] activation by TGF-beta(1) , and consequently attenuated TGF-beta(1) enhancement of its own mRNA expression in PSCs . Positive_regulation EPHB2 MAP2K6 14719071 1197691 In cisplatin-resistant UM-SCC-23 in culture , which we have established , the protein levels of Ras , Raf-1 and were drastically elevated compared to parent UM-SCC-23 , and [ERK] and Akt signals were constitutively *activated* . Positive_regulation EPHB2 MAP2K6 15159408 1273324 Use of U0126 revealed that palytoxin *requires* the ERK kinase to stimulate [ERK] activity , although palytoxin did not activate MEK . Positive_regulation EPHB2 MAP2K6 15174091 1254269 Conversely , treatment with U0126 , a potent inhibitor of mediated [ERK] *activation* , prevented FAK phosphorylation at Ser-910 induced by PDGF but did not interfere with PDGF induced FAK phosphorylation at Tyr-397 . Positive_regulation EPHB2 MAP2K6 15304546 1322384 Furthermore , *activation* of [ERK/MAPK] by the coexpression of constitutively active predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation EPHB2 MAP2K6 15537634 1360475 [ERK] activation was *prevented* by inhibitors that had no effect on PYK2 . Positive_regulation EPHB2 MAP2K6 15607817 1357030 Furthermore , U0126 and LY294002 , which respectively inhibit *induced* [ERK] phosphorylation and PI3 kinase mediated Akt phosphorylation had distinct effects on C3a induced responses . Positive_regulation EPHB2 MAP2K6 15652235 1364135 PD98059 , a inhibitor , and BAY 11-8702 , an I kappa B-alpha inhibitor , *reduced* [ERK] and NF-kappa B cascade activation , respectively , with little effect on PKC phosphorylation . Positive_regulation EPHB2 MAP2K6 15674440 1350828 [ERK] phosphorylation was *reduced* by a inhibitor , PD98059 . Positive_regulation EPHB2 MAP2K6 15691837 1388551 In its central portion *activates* [ERK] , leading to increased collagen expression . Positive_regulation EPHB2 MAP2K6 15749869 1379692 We found that prior stimulation of primary murine B cells with CD40L markedly enhanced the level of ERK and JNK ( but not p38 MAPK ) phosphorylation produced by subsequently added anti-Ig Ab , and much , but not all , of this enhancement was independent of PI3K and phospholipase C . CD40L treatment similarly enhanced BCR induced MAPK kinase ( MEK ) phosphorylation , and was *required* for enhancement of [ERK] . Positive_regulation EPHB2 MAP2K6 15750341 1379874 These findings indicate that [ERK] phosphorylation in response to glycated LDL *involves* the activation of PKC , PLC , and , but is independent of intracellular Ca2+ . Positive_regulation EPHB2 MAP2K6 15801908 1432344 The ( MAPK/ERK kinase ) inhibitors PD98059 and U0126 *blocked* IGF-I stimulated [ERK] phosphorylation but did not block the phosphorylation of Akt and did not decrease proteoglycan synthesis . Positive_regulation EPHB2 MAP2K6 15843032 1398310 Treatment of myoblasts with LIF induced phosphorylation of [ERK] , and the LIF induced inhibitory effect on myogenesis was *blocked* by pretreatment with U0126 , a specific inhibitor , and transient transfection with dominant negative ( DN ) -MEK1 . Positive_regulation EPHB2 MAP2K6 15843535 1398467 As in the classical pathway , BCR induced [ERK] activation in the new , PI3K independent pathway *required* and was reflected in c-Raf . Positive_regulation EPHB2 MAP2K6 15855657 1439590 Activation of ERK was attenuated by drugs that disassemble the actin cytoskeleton ( cytochalasin D , latrunculin B ) , and these compounds interfered with the *activation* of [ERK] by ( MEK ) . Positive_regulation EPHB2 MAP2K6 16189274 1507735 In MET positive DLBCL cells , HGF induces *dependent* activation of [ERK] and PI3K dependent phosphorylation of PKB , GSK3 , and FOXO3a . Positive_regulation EPHB2 MAP2K6 16360949 1504584 The phospho-ERK and phospho-MEK profiles were similar , suggesting that [ERK] phosphorylation is *regulated* by . Positive_regulation EPHB2 MAP2K6 16877565 1638801 However , inhibitors of Raf-1 and or a dominant negative ERK mutant *blocked* FKN induced [ERK] , but not Akt and eNOS , phosphorylation . Positive_regulation EPHB2 MAP2K6 16983658 1633620 In parallel , farnesyltransferase and inhibitors *blocked* [ERK] phosphorylation and neuroprotective effect of NAC . Positive_regulation EPHB2 MAP2K6 17130674 1661371 PD98059 , a ( mitogen activated protein kinase kinase ) inhibitor , and BAPTA-AM [ O , O'-bis ( 2-aminophenyl ) ethyleneglycol-N , N,N ' , N'-tetraacetic acid , tetraacetoxymethyl ester ] , an intracellular Ca ( 2+ ) chelator , *reduced* UTP induced [ERK] phosphorylation and IL-6 mRNA expression . Positive_regulation EPHB2 MAP2K6 17182785 1662668 Specifically , inhibition of GSK-3beta led to increased [ERK] phosphorylation , and inhibition of completely *blocked* the effects of GSK-3beta inhibition on dendrite initiation and growth . Positive_regulation EPHB2 MAP2K6 17189385 1662772 In addition , inhibitor ( PD98059 ) *reduced* the interaction between p65 and [ERK] . Positive_regulation EPHB2 MAP2K6 17337598 1765822 A pharmacological inhibitor of activity *inhibits* LPA stimulated WT Hic-5 cell migration and [ERK] phosphorylation , suggesting Hic-5 enhances migration via MEK activation of ERK . Positive_regulation EPHB2 MAP2K6 17379261 1720780 FTY720P augmented [ERK] phosphorylation in cortical cultures prepared from embryonic day 18 rat brains and was *blocked* by an inhibitor or by pertussis toxin . Positive_regulation EPHB2 MAP2K6 17526574 1784071 , once phosphorylated by Raf , *triggers* [Erk] phosphorylation , which in turn induces dissociation of Raf-inaccessible Mek-Erk heterodimers , and thus further amplifies Mek phosphorylation . Positive_regulation EPHB2 MAP2K6 18068691 1853773 This mechanism was found to be specific to etorphine , as activation of [ERK] by the micro-opioid receptor ( MOR ) agonist DAMGO ( [ D-Ala ( 2 ) , N-Me-Phe ( 4 ) , Gly ( 5 ) -ol ] enkephalin ) was *mediated* by in these cells , suggesting that etorphine and DAMGO activate distinct , ligand-specific , conformations of MOR . Positive_regulation EPHB2 MAP2K6 18401006 1925755 CyaA enhanced LPS induced phosphorylation of p38 MAPK and [ERK] in DC , and inhibitors of p38 MAPK , , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation EPHB2 MAP2K6 18454176 1951545 Moreover , GATA-6 was phosphorylated at serine residues by *activated* [ERK] , which increased GATA-6 DNA binding , correlating with suppression of the Nox1 promoter activity by an MEK inhibitor PD98059 . Positive_regulation EPHB2 MAP2K6 18632602 1937018 A selective inhibitor , AZD6244 , *inhibits* mutant induced [ERK] activity in 293T cells and growth of mutant bearing Ba/F3 cells . Positive_regulation EPHB2 MAP2K6 18656513 1972855 was *required* for phosphorylation of [ERK] and CREB , but not Akt , whereas G ( 0 ) /G ( i ) -proteins were necessary for phosphorylation of Akt and CREB , and cGMP was necessary for Akt phosphorylation . Positive_regulation EPHB2 MAP2K6 18695640 1973873 ROCK inhibition also reduced 5-HT stimulated proliferation by suppressing *stimulated* [ERK] phosphorylation . Positive_regulation EPHB2 MAP2K6 18711316 2006003 Moreover , pretreatment with DIDS ( Cl- channel blockers ) but not LY294002 ( PI3K inhibitors ) completely abolished the LDL induced upregulation of Egr-1 to the same extent as PD98059 ( inhibitors to *inhibit* [Erk] ) , as judged by Western blot and luciferase reporter assays . Positive_regulation EPHB2 MAP2K6 18771726 1980336 We demonstrated here , that PTPIP51 could regulate ERK activity on Raf level , since inhibitor and dominant negative Raf-1 but not Ras could *inhibit* the [ERK] activation induced by PTPIP51 . Positive_regulation EPHB2 MAP2K6 19098317 2047664 PI3K inhibitor ( Ly294002 ) significantly decreased pAkt activity and HIF-1alpha and VEGF expression in vivo and in vitro , whereas inhibitor ( PD98059 ) *reduced* [ERK] phosphorylation and the expression of VEGF but had no effect on HIF-1alpha . Positive_regulation EPHB2 MAP2K6 19176641 2061152 U-0126 , the ( MAPK kinase ) inhibitors *blocked* [ERK] activation and cell proliferation induced by diazoxide . Positive_regulation EPHB2 MAP2K6 19241161 2086560 Furthermore , we also demonstrated here that Zn2+ stimulates the phosphorylation of [ERK] and that the pathway inhibitor , U0126 , *suppressed* Zn2+ induced PUMA expression . Positive_regulation EPHB2 MAP2K6 19319189 2052423 multiprotein complex to *promote* sustained [ERK] activation and regulate H-Ras dependent neuritogenesis . Positive_regulation EPHB2 MAP2K6 19703440 2158083 Furthermore , [ERK] activation and angiogenic sprouting in response to NMB are significantly *blocked* by the inhibitor . Positive_regulation EPHB2 MAP2K6 20526801 2320144 Furthermore , we also demonstrate that either chemical inhibition of ( U0126 ) or stable downregulation of PDGFRß by shRNA similarly results in the *loss* of PDGF induced [ERK] phosphorylation and abolishes Rac1/Pak1 activation and cell migration in response to PDGF . Positive_regulation EPHB2 MAP2K6 20542106 2301957 Activation of these pathways by ATP seemed to be independent , since LY294002 and U0126 , inhibitors of PI3K and , did not *block* the activation of [ERK] and AKT , respectively , although each compound blocked its respective target . Positive_regulation EPHB2 MAP2K6 20668238 2305307 inhibitors *inhibit* [ERK] phosphorylation in all normal and tumor cells , whereas PLX4032 inhibits ERK signaling only in tumor cells expressing BRAF ( V600E ) . Positive_regulation EPHB2 MAP2K6 20668435 2317108 In addition , DHA caused AKT and [ERK] activation in a time dependent manner , and the DHA induced HO-1 upregulation could be *attenuated* by PI-3 kinase/AKT and inhibitors . Positive_regulation EPHB2 MAP2K6 21088259 2389776 These cells displayed high levels of ERK activation , that is , at least in part , independent of the conventional RAF/MEK/ERK pathway , as MEK activation was low and inhibition of did not significantly *block* activation of [ERK] . Positive_regulation EPHB2 MAP2K6 21106560 2395800 Experiments carried out with pharmacological inhibitors show that *dependent* [ERK] and phosphatidylinositol 3-kinase dependent AKT pathways are positive regulators of the lectin- and insulin mediated adipogenic differentiation , while stress activated kinase/c-jun N-terminal kinase pathway acts as a negative one . Positive_regulation EPHB2 MAP2K6 21336309 2399447 Expression of un-SUMOylatable *enhanced* [ERK] activation , cell differentiation , proliferation and malignant transformation by oncogenic ErbB2 or Raf , but not by active Ras . Positive_regulation EPHB2 MAP2K6 21665194 2446305 inhibitors and alpha7-nicotinic acetylcholine receptor ( a7nAChR ) antagonist *blocked* the neurite outgrowth and the activation of [ERK] induced by B12H . Positive_regulation EPHB2 MAP2K6 22087839 2514177 Therefore , inhibition of mediated [ERK] *activation* is very appealing in cancer therapy . Positive_regulation EPHB2 MAP2K6 22087839 2514184 Inhibition of mediated [ERK] *activation* , therefore , compromises checkpoint activation . Positive_regulation EPHB2 MAP2K6 22278923 2551574 By contrast , in human embryos , inhibition of MEK did not significantly alter epiblast or hypoblast precursor numbers despite the ability of the inhibitor to potently *inhibit* [ERK] phosphorylation in human ES cells . Positive_regulation EPHB2 MAP2K6 22328534 2642856 PD98059 , inhibitor , or U0126 , [ERK] *inhibitor* , reduced SNU668 cell migration accompanying an increase in p-GSK-3a , ß-catenin and E-cadherin . Positive_regulation EPHB2 MAP2K6 22556409 2614119 [ERK] activation was *prevented* by inhibitors and was associated with concurrent stimulation of RAF kinase activity but not RAS activation . Positive_regulation EPHB2 MAP2K6 22740332 2715443 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Positive_regulation EPHB2 MAP2K6 22785235 2691768 TRH induced CRE promoter was inhibited by mitogen activated protein [kinase/ERK] kinase ( MEK ) inhibitor and was *increased* by overexpression of . Positive_regulation EPHB2 MAP2K6 22892241 2666332 However , unlike ( V600E ) Braf , [Mek/Erk] pathway activation was mediated by both Craf and Braf , and ATP-competitive RAF inhibitors *induced* paradoxical pathway activation . Positive_regulation EPHB2 MAP2K6 22906417 2678034 Furthermore , post-EMT cells exhibited decreased basal Raf and [Erk] phosphorylation , and in comparison to pre-EMT cells , their proliferation was poorly *inhibited* by a inhibitor . Positive_regulation EPHB2 MAP2K6 23102728 2729194 inhibitors , either AZD6244 or CI1040 , *inhibited* [ERK] phosphorylation and sensitized gefitinib induced cytotoxicity in PC-9/gef cells . Positive_regulation EPHB2 MAP2K6 23210697 2736384 Complete [ERK] *activation* by the kinase requires dual phosphorylation at T and Y within the activation motif TEY . Positive_regulation EPHB2 MAP2K6 23360980 2758735 Consequently , coexpression of wildtype C-Raf and was *sufficient* for full and constitutive activation of [ERK] . Positive_regulation EPHB2 MAP2K6 23499828 2827636 H2S stimulated T cell activation by potentiating *dependent* [ERK] phosphorylation , and thrombospondin-1 inhibited this signaling in a CD47 dependent manner . Positive_regulation EPHB2 MAP2K6 23806683 2820637 [ERK] *activation* by the over-expression of constitutively active increased protein levels and enhanced the stability of SIRT2 . Positive_regulation EPHB2 MAP2K6 24530412 2924281 It is noteworthy that a tyrosine kinase receptor inhibitor , K252a , an inhibitor ( U0126 ) , and a PI3Kinase-Akt inhibitor ( LY294002 ) remarkably *attenuated* TrkB , [ERK] , and Akt phosphorylation as well as increase of OPN mRNA expression in the HCEM cells , respectively . Positive_regulation EPHB2 MAP2K6 24746704 2936462 Here , we found that inhibitors *suppress* [ERK] signaling more potently in BRAF ( V600E ) , than in KRAS mutant tumors . Positive_regulation EPHB2 MAP2K6 8226933 235294 *Activation* of extracellular signal regulated kinase ( [ERK] ) or mitogen activated protein kinase by ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation EPHB2 MAP2K6 8552085 347158 Expression of a dominant interfering mutant , in which lysine 97 was replaced with arginine ( MEK/K97R ) , *resulted* in an inhibition of insulin stimulated SOS and [ERK] phosphorylation , whereas expression of a constitutively active MEK mutant , in which serines 218 and 222 were replaced with glutamic acid ( MEK/EE ) , induced basal phosphorylation of both SOS and ERK . Positive_regulation EPHB2 MAP2K6 9390997 467677 Furthermore , overexpression of a kinase-inactive mutant *inhibited* phorbol ester stimulation of APP secretion and activation of [ERK] in human embryonic kidney cell lines . Positive_regulation EPHB2 MAP2K6 9442025 482991 Arsenite induced [ERK] activation is *mediated* by Ras , Raf , and but appears to be independent of de novo protein synthesis . Positive_regulation EPHB2 MAP2K6 9687508 522241 Consistently , *induced* [ERK] activation in PC12 cells induces c-Jun expression , while JNK signalling does not . Positive_regulation EPHB2 MAP2K6 9826736 550739 Inhibition of ( proximal activator of Erk ) also *blocked* stimulation of [Erk] and adhesion by formylmethionyl-leucyl-phenylalanineand arachidonic acid . Positive_regulation EPHB2 MAP2K6 9864179 582703 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of [ERK] , but not p38 MAPK , induced by G-CSF , GM-CSF , or TNF . Positive_regulation EPHB2 MAP2K7 10383890 624673 The inhibitor , PD 098059 *inhibited* EGF stimulated proliferation and [ERK] activity in a parallel , dose dependent manner showing that ERK activation is at least permissive for the proliferative response to EGF . Positive_regulation EPHB2 MAP2K7 10402467 628944 Ras and were *necessary* and sufficient for uPA induced [ERK] activation and stimulation of cellular migration , as demonstrated in experiments with dominant negative and constitutively active mutants of these signaling proteins . Positive_regulation EPHB2 MAP2K7 10523856 653798 The inhibitor PD 098059 , as well as the PKC inhibitors , completely *blocked* TPA mediated [ERK] activation . Positive_regulation EPHB2 MAP2K7 10688043 669960 Inhibition of EGF- and LPA- induced [ERK] activation with the EGF receptor inhibitor , AG1478 , or the inhibitor , PD98059 , *attenuated* their proliferative effects . Positive_regulation EPHB2 MAP2K7 10700616 672428 We have therefore hypothesized that [ERK] *activation* through is required for optimal induction of neurite growth by these proteins . Positive_regulation EPHB2 MAP2K7 10783161 688176 Sur-8 expression enhances Ras- or EGF induced Raf and ERK activation but has no effect on [ERK] activation *induced* by active Raf or . Positive_regulation EPHB2 MAP2K7 10888263 710246 However , PD098059 mediated inhibition of *dependent* stimulation of [ERK] did not alter the hypertrophic response of either agonist . Positive_regulation EPHB2 MAP2K7 10965502 727993 17 beta-oestradiol increased B-Raf activity and *dependent* [ERK] phosphorylation in explants of wild-type and ERKO cerebral cortex . Positive_regulation EPHB2 MAP2K7 10996792 733912 As in proliferating cells , [ERK] activation during G0 *required* the MAPkinase kinase and was partially dependent on cell adhesion . Positive_regulation EPHB2 MAP2K7 11005808 752396 A inhibitor , PD98059 , *inhibited* heat shock [ERK] MAPK activation by > 75 % . Positive_regulation EPHB2 MAP2K7 11311983 805184 This provides evidence for a novel pathway linking striatal kainate receptors to [ERK] *activation* via PI3 kinase and . Positive_regulation EPHB2 MAP2K7 11359871 816504 6-OHDA elicited ERK phosphorylation was blocked by PD98059 , an inhibitor of the upstream ( MEK ) that phosphorylates and *activates* [ERK] . Positive_regulation EPHB2 MAP2K7 11413312 828904 The inhibitors PD98059 and U0126 *blocked* [Erk] activation and release of IL-8 following infection with Ad7 . Positive_regulation EPHB2 MAP2K7 11418608 843270 VPA induced *activation* of [ERK] was blocked by the mitogen activated protein kinase/ERK kinase inhibitor PD098059 and dominant negative Ras and Raf mutants but not by dominant negative stress activated protein kinase/ERK kinase and 6 mutants . Positive_regulation EPHB2 MAP2K7 11546664 856574 The mitogen activated protein kinase (MAPK) kinase ( ) inhibitors , PD-98059 and U-0126 , *blocked* IL-1 alpha induced [ERK] activation and partially attenuated cPLA(2)alpha phosphorylation and PGI ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation EPHB2 MAP2K7 11564685 863264 The specific Mek inhibitor , PD98059 , blocked the activation of the Erks by ACTH and basic fibroblast growth factor , indicating that is the upstream *activator* of [Erk] . Positive_regulation EPHB2 MAP2K7 11641250 872082 Stimulation of [Erk] activity was *due* to activation of Ras , Raf-1 , and ( MAPK kinase ) . Positive_regulation EPHB2 MAP2K7 11804669 903329 PD 98059 , a inhibitor , and glutathione , an anti-thiol-oxidant , not only *blocked* Cpd 5-induced [ERK] phosphorylation , but also antagonized the activation of CPP-32 , the altered Bcl-2/Bax expression , and DNA fragmentation . Positive_regulation EPHB2 MAP2K7 11812003 907194 The inhibitors , U0126 and PD-98059 , dose-dependently *inhibited* the [ERK] activity stimulated by EGF . Positive_regulation EPHB2 MAP2K7 11841924 912282 PMA also phosphorylated MEK and [ERK] , and PMA induced GATA-4 phosphorylation was *blocked* by an inhibitor , PD98059 , suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway . Positive_regulation EPHB2 MAP2K7 12055096 951685 The inhibitors PD-98059 and U-0126 *blocked* [ERK] activation mediated by diazoxide . Positive_regulation EPHB2 MAP2K7 12070086 955774 Addition of inhibitor in the culture medium *prevented* [ERK] activation and metamorphosis . Positive_regulation EPHB2 MAP2K7 12364324 1019140 GLP1 stimulated activation of [Erk] is *blocked* by inhibitors of , but GLP1 does not induce the activation of A-Raf , B-Raf , C-Raf , or Ras . Positive_regulation EPHB2 MAP2K7 12493768 1056686 Consistent with this premise , FSH stimulated [ERK] activation is *inhibited* by the cell-permeable protein kinase A-specific inhibitor peptide Myr-PKI as well as by inhibitors of , Src , a Ca ( 2+ ) channel blocker , and chelation of extracellular Ca ( 2+ ) . Positive_regulation EPHB2 MAP2K7 12506070 1038327 A specific inhibitor of *blocked* the TNFalpha induction of the MMPs and TIMPs and the phosphorylation of [Erk] . Positive_regulation EPHB2 MAP2K7 12514175 1063807 Low K ( + ) *induced* delayed and persistent [ERK] activation , which was blocked by inhibitors or GDF-15 . Positive_regulation EPHB2 MAP2K7 12588763 1059638 inhibitors U0126 and PD98059 *blocked* both [ERK] activation and the increase in TF mRNA . Positive_regulation EPHB2 MAP2K7 12657694 1073290 [ERK] activation was *blocked* by inhibiting , the upstream activator of ERK . Positive_regulation EPHB2 MAP2K7 12664642 1030355 Inhibition of ( proximal activator of Erk ) also *blocked* stimulation of [Erk] and neutrophil aggregation by FMLP and arachidonic acid . Positive_regulation EPHB2 MAP2K7 12675684 1076703 In contrast , the *activation* of [ERK] by constitutively active forms of was not inhibited , suggesting that the actions of SptP were mediated by Raf-1 . Positive_regulation EPHB2 MAP2K7 12686598 1078129 In unstimulated cells , tropomyosin-1 was found diffuse in the cells , whereas it quickly colocalized with actin and stress fibers upon *stimulation* of [ERK] by H ( 2 ) O ( 2 ) or by expression of ( CA ) . Positive_regulation EPHB2 MAP2K7 12706116 1082488 In PC12 cells , NGF and EGF induce a rapid translocation of [GFP-Erk] that *requires* Ras and . Positive_regulation EPHB2 MAP2K7 12736249 1107192 We observed that growth stimulation was associated with stimulation of ERK1/2 phosphorylation (ERK-P) , and both growth and [ERK-P] could be *blocked* by the inhibitor ( U0126 , 100 nm ) . Positive_regulation EPHB2 MAP2K7 12738796 1107269 Surprisingly , this induction of phosphorylation does not *result* in [ERK] activation in vivo . Positive_regulation EPHB2 MAP2K7 12758056 1090987 Inhibition of *induced* [ERK] phosphorylation had no effect on adipogenesis but prevented this TCDD suppression . Positive_regulation EPHB2 MAP2K7 12850584 1109568 Abeta induced [ERK] phosphorylation was completely *blocked* by the inhibitors , while Abeta induced promotion of extracellular L-glutamate clearance was enhanced by the presence of the MEK inhibitors . Positive_regulation EPHB2 MAP2K7 14514659 1185730 A low level ( 2 micro M ) of arsenite stimulated extracellular signal regulated kinase ( ERK ) signaling pathway and enhanced cell proliferation , and this arsenite induced [ERK] activity was *blocked* by inhibitor , PD98059 . Positive_regulation EPHB2 MAP2K7 14517212 1164979 The inhibitors PD 98059 and U0126 *blocked* [ERK] phosphorylation , as did the adenylate cyclase activator forskolin . Positive_regulation EPHB2 MAP2K7 14555984 1153217 In androgen depleted condition , PD98059 , an inhibitor , could efficiently *block* not only the activation of [ERK] , but also the acquisition of the NE-like morphology and the elevation of NSE in C-33 LNCaP cells . Positive_regulation EPHB2 MAP2K7 14563359 1154811 Experiments based on inhibitors of specific signaling pathways , such as manumycin A , toxin A , U0126 , PD98059 and wortmannin revealed that Ras , and PI-3K are *involved* in the activation of [ERK] . Positive_regulation EPHB2 MAP2K7 14688282 1211514 However , PD98059 , a specific inhibitor of ( MEK1 ) , *inhibited* [ERK] activation by TGF-beta(1) , and consequently attenuated TGF-beta(1) enhancement of its own mRNA expression in PSCs . Positive_regulation EPHB2 MAP2K7 14719071 1197692 In cisplatin-resistant UM-SCC-23 in culture , which we have established , the protein levels of Ras , Raf-1 and were drastically elevated compared to parent UM-SCC-23 , and [ERK] and Akt signals were constitutively *activated* . Positive_regulation EPHB2 MAP2K7 15159408 1273325 Use of U0126 revealed that palytoxin *requires* the ERK kinase to stimulate [ERK] activity , although palytoxin did not activate MEK . Positive_regulation EPHB2 MAP2K7 15174091 1254270 Conversely , treatment with U0126 , a potent inhibitor of mediated [ERK] *activation* , prevented FAK phosphorylation at Ser-910 induced by PDGF but did not interfere with PDGF induced FAK phosphorylation at Tyr-397 . Positive_regulation EPHB2 MAP2K7 15304546 1322385 Furthermore , *activation* of [ERK/MAPK] by the coexpression of constitutively active predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation EPHB2 MAP2K7 15537634 1360476 [ERK] activation was *prevented* by inhibitors that had no effect on PYK2 . Positive_regulation EPHB2 MAP2K7 15607817 1357031 Furthermore , U0126 and LY294002 , which respectively inhibit *induced* [ERK] phosphorylation and PI3 kinase mediated Akt phosphorylation had distinct effects on C3a induced responses . Positive_regulation EPHB2 MAP2K7 15652235 1364136 PD98059 , a inhibitor , and BAY 11-8702 , an I kappa B-alpha inhibitor , *reduced* [ERK] and NF-kappa B cascade activation , respectively , with little effect on PKC phosphorylation . Positive_regulation EPHB2 MAP2K7 15674440 1350829 [ERK] phosphorylation was *reduced* by a inhibitor , PD98059 . Positive_regulation EPHB2 MAP2K7 15691837 1388552 In its central portion *activates* [ERK] , leading to increased collagen expression . Positive_regulation EPHB2 MAP2K7 15749869 1379693 We found that prior stimulation of primary murine B cells with CD40L markedly enhanced the level of ERK and JNK ( but not p38 MAPK ) phosphorylation produced by subsequently added anti-Ig Ab , and much , but not all , of this enhancement was independent of PI3K and phospholipase C . CD40L treatment similarly enhanced BCR induced MAPK kinase ( MEK ) phosphorylation , and was *required* for enhancement of [ERK] . Positive_regulation EPHB2 MAP2K7 15750341 1379875 These findings indicate that [ERK] phosphorylation in response to glycated LDL *involves* the activation of PKC , PLC , and , but is independent of intracellular Ca2+ . Positive_regulation EPHB2 MAP2K7 15801908 1432345 The ( MAPK/ERK kinase ) inhibitors PD98059 and U0126 *blocked* IGF-I stimulated [ERK] phosphorylation but did not block the phosphorylation of Akt and did not decrease proteoglycan synthesis . Positive_regulation EPHB2 MAP2K7 15843032 1398311 Treatment of myoblasts with LIF induced phosphorylation of [ERK] , and the LIF induced inhibitory effect on myogenesis was *blocked* by pretreatment with U0126 , a specific inhibitor , and transient transfection with dominant negative ( DN ) -MEK1 . Positive_regulation EPHB2 MAP2K7 15843535 1398468 As in the classical pathway , BCR induced [ERK] activation in the new , PI3K independent pathway *required* and was reflected in c-Raf . Positive_regulation EPHB2 MAP2K7 15855657 1439591 Activation of ERK was attenuated by drugs that disassemble the actin cytoskeleton ( cytochalasin D , latrunculin B ) , and these compounds interfered with the *activation* of [ERK] by ( MEK ) . Positive_regulation EPHB2 MAP2K7 16189274 1507736 In MET positive DLBCL cells , HGF induces dependent *activation* of [ERK] and PI3K dependent phosphorylation of PKB , GSK3 , and FOXO3a . Positive_regulation EPHB2 MAP2K7 16360949 1504585 The phospho-ERK and phospho-MEK profiles were similar , suggesting that [ERK] phosphorylation is *regulated* by . Positive_regulation EPHB2 MAP2K7 16877565 1638802 However , inhibitors of Raf-1 and or a dominant negative ERK mutant *blocked* FKN induced [ERK] , but not Akt and eNOS , phosphorylation . Positive_regulation EPHB2 MAP2K7 16983658 1633621 In parallel , farnesyltransferase and inhibitors *blocked* [ERK] phosphorylation and neuroprotective effect of NAC . Positive_regulation EPHB2 MAP2K7 17130674 1661372 PD98059 , a ( mitogen activated protein kinase kinase ) inhibitor , and BAPTA-AM [ O , O'-bis ( 2-aminophenyl ) ethyleneglycol-N , N,N ' , N'-tetraacetic acid , tetraacetoxymethyl ester ] , an intracellular Ca ( 2+ ) chelator , *reduced* UTP induced [ERK] phosphorylation and IL-6 mRNA expression . Positive_regulation EPHB2 MAP2K7 17182785 1662669 Specifically , inhibition of GSK-3beta led to increased [ERK] phosphorylation , and inhibition of completely *blocked* the effects of GSK-3beta inhibition on dendrite initiation and growth . Positive_regulation EPHB2 MAP2K7 17189385 1662773 In addition , inhibitor ( PD98059 ) *reduced* the interaction between p65 and [ERK] . Positive_regulation EPHB2 MAP2K7 17337598 1765823 A pharmacological inhibitor of activity *inhibits* LPA stimulated WT Hic-5 cell migration and [ERK] phosphorylation , suggesting Hic-5 enhances migration via MEK activation of ERK . Positive_regulation EPHB2 MAP2K7 17379261 1720781 FTY720P augmented [ERK] phosphorylation in cortical cultures prepared from embryonic day 18 rat brains and was *blocked* by an inhibitor or by pertussis toxin . Positive_regulation EPHB2 MAP2K7 17526574 1784072 , once phosphorylated by Raf , *triggers* [Erk] phosphorylation , which in turn induces dissociation of Raf-inaccessible Mek-Erk heterodimers , and thus further amplifies Mek phosphorylation . Positive_regulation EPHB2 MAP2K7 18068691 1853774 This mechanism was found to be specific to etorphine , as activation of [ERK] by the micro-opioid receptor ( MOR ) agonist DAMGO ( [ D-Ala ( 2 ) , N-Me-Phe ( 4 ) , Gly ( 5 ) -ol ] enkephalin ) was *mediated* by in these cells , suggesting that etorphine and DAMGO activate distinct , ligand-specific , conformations of MOR . Positive_regulation EPHB2 MAP2K7 18401006 1925756 CyaA enhanced LPS induced phosphorylation of p38 MAPK and [ERK] in DC , and inhibitors of p38 MAPK , , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation EPHB2 MAP2K7 18454176 1951546 Moreover , GATA-6 was phosphorylated at serine residues by *activated* [ERK] , which increased GATA-6 DNA binding , correlating with suppression of the Nox1 promoter activity by an MEK inhibitor PD98059 . Positive_regulation EPHB2 MAP2K7 18632602 1937019 A selective inhibitor , AZD6244 , *inhibits* mutant induced [ERK] activity in 293T cells and growth of mutant bearing Ba/F3 cells . Positive_regulation EPHB2 MAP2K7 18656513 1972856 was *required* for phosphorylation of [ERK] and CREB , but not Akt , whereas G ( 0 ) /G ( i ) -proteins were necessary for phosphorylation of Akt and CREB , and cGMP was necessary for Akt phosphorylation . Positive_regulation EPHB2 MAP2K7 18695640 1973874 ROCK inhibition also reduced 5-HT stimulated proliferation by suppressing *stimulated* [ERK] phosphorylation . Positive_regulation EPHB2 MAP2K7 18711316 2006004 Moreover , pretreatment with DIDS ( Cl- channel blockers ) but not LY294002 ( PI3K inhibitors ) completely abolished the LDL induced upregulation of Egr-1 to the same extent as PD98059 ( inhibitors to *inhibit* [Erk] ) , as judged by Western blot and luciferase reporter assays . Positive_regulation EPHB2 MAP2K7 18771726 1980337 We demonstrated here , that PTPIP51 could regulate ERK activity on Raf level , since inhibitor and dominant negative Raf-1 but not Ras could *inhibit* the [ERK] activation induced by PTPIP51 . Positive_regulation EPHB2 MAP2K7 19098317 2047665 PI3K inhibitor ( Ly294002 ) significantly decreased pAkt activity and HIF-1alpha and VEGF expression in vivo and in vitro , whereas inhibitor ( PD98059 ) *reduced* [ERK] phosphorylation and the expression of VEGF but had no effect on HIF-1alpha . Positive_regulation EPHB2 MAP2K7 19176641 2061153 U-0126 , the ( MAPK kinase ) inhibitors *blocked* [ERK] activation and cell proliferation induced by diazoxide . Positive_regulation EPHB2 MAP2K7 19241161 2086561 Furthermore , we also demonstrated here that Zn2+ stimulates the phosphorylation of [ERK] and that the pathway inhibitor , U0126 , *suppressed* Zn2+ induced PUMA expression . Positive_regulation EPHB2 MAP2K7 19319189 2052424 multiprotein complex to *promote* sustained [ERK] activation and regulate H-Ras dependent neuritogenesis . Positive_regulation EPHB2 MAP2K7 19703440 2158084 Furthermore , [ERK] activation and angiogenic sprouting in response to NMB are significantly *blocked* by the inhibitor . Positive_regulation EPHB2 MAP2K7 20526801 2320145 Furthermore , we also demonstrate that either chemical inhibition of ( U0126 ) or stable downregulation of PDGFRß by shRNA similarly *results* in the loss of PDGF induced [ERK] phosphorylation and abolishes Rac1/Pak1 activation and cell migration in response to PDGF . Positive_regulation EPHB2 MAP2K7 20542106 2301958 Activation of these pathways by ATP seemed to be independent , since LY294002 and U0126 , inhibitors of PI3K and , did not *block* the activation of [ERK] and AKT , respectively , although each compound blocked its respective target . Positive_regulation EPHB2 MAP2K7 20668238 2305308 inhibitors *inhibit* [ERK] phosphorylation in all normal and tumor cells , whereas PLX4032 inhibits ERK signaling only in tumor cells expressing BRAF ( V600E ) . Positive_regulation EPHB2 MAP2K7 20668435 2317109 In addition , DHA caused AKT and [ERK] activation in a time dependent manner , and the DHA induced HO-1 upregulation could be *attenuated* by PI-3 kinase/AKT and inhibitors . Positive_regulation EPHB2 MAP2K7 21088259 2389777 These cells displayed high levels of ERK activation , that is , at least in part , independent of the conventional RAF/MEK/ERK pathway , as MEK activation was low and inhibition of did not significantly *block* activation of [ERK] . Positive_regulation EPHB2 MAP2K7 21106560 2395801 Experiments carried out with pharmacological inhibitors show that *dependent* [ERK] and phosphatidylinositol 3-kinase dependent AKT pathways are positive regulators of the lectin- and insulin mediated adipogenic differentiation , while stress activated kinase/c-jun N-terminal kinase pathway acts as a negative one . Positive_regulation EPHB2 MAP2K7 21336309 2399448 Expression of un-SUMOylatable *enhanced* [ERK] activation , cell differentiation , proliferation and malignant transformation by oncogenic ErbB2 or Raf , but not by active Ras . Positive_regulation EPHB2 MAP2K7 21665194 2446306 inhibitors and alpha7-nicotinic acetylcholine receptor ( a7nAChR ) antagonist *blocked* the neurite outgrowth and the activation of [ERK] induced by B12H . Positive_regulation EPHB2 MAP2K7 22087839 2514178 Therefore , inhibition of mediated [ERK] *activation* is very appealing in cancer therapy . Positive_regulation EPHB2 MAP2K7 22087839 2514185 Inhibition of mediated [ERK] *activation* , therefore , compromises checkpoint activation . Positive_regulation EPHB2 MAP2K7 22278923 2551575 By contrast , in human embryos , inhibition of MEK did not significantly alter epiblast or hypoblast precursor numbers despite the ability of the inhibitor to potently *inhibit* [ERK] phosphorylation in human ES cells . Positive_regulation EPHB2 MAP2K7 22328534 2642857 PD98059 , inhibitor , or U0126 , [ERK] *inhibitor* , reduced SNU668 cell migration accompanying an increase in p-GSK-3a , ß-catenin and E-cadherin . Positive_regulation EPHB2 MAP2K7 22556409 2614120 [ERK] activation was *prevented* by inhibitors and was associated with concurrent stimulation of RAF kinase activity but not RAS activation . Positive_regulation EPHB2 MAP2K7 22740332 2715444 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Positive_regulation EPHB2 MAP2K7 22785235 2691769 TRH induced CRE promoter was inhibited by mitogen activated protein [kinase/ERK] kinase ( MEK ) inhibitor and was *increased* by overexpression of . Positive_regulation EPHB2 MAP2K7 22892241 2666333 However , unlike ( V600E ) Braf , pathway activation was mediated by both Craf and Braf , and ATP-competitive RAF inhibitors *induced* paradoxical [Mek/Erk] pathway activation . Positive_regulation EPHB2 MAP2K7 22906417 2678035 Furthermore , post-EMT cells exhibited decreased basal Raf and [Erk] phosphorylation , and in comparison to pre-EMT cells , their proliferation was poorly *inhibited* by a inhibitor . Positive_regulation EPHB2 MAP2K7 23102728 2729195 inhibitors , either AZD6244 or CI1040 , *inhibited* [ERK] phosphorylation and sensitized gefitinib induced cytotoxicity in PC-9/gef cells . Positive_regulation EPHB2 MAP2K7 23210697 2736385 Complete [ERK] *activation* by the kinase requires dual phosphorylation at T and Y within the activation motif TEY . Positive_regulation EPHB2 MAP2K7 23360980 2758736 Consequently , coexpression of wildtype C-Raf and was *sufficient* for full and constitutive activation of [ERK] . Positive_regulation EPHB2 MAP2K7 23499828 2827637 H2S stimulated T cell activation by potentiating *dependent* [ERK] phosphorylation , and thrombospondin-1 inhibited this signaling in a CD47 dependent manner . Positive_regulation EPHB2 MAP2K7 23806683 2820638 [ERK] *activation* by the over-expression of constitutively active increased protein levels and enhanced the stability of SIRT2 . Positive_regulation EPHB2 MAP2K7 24530412 2924282 It is noteworthy that a tyrosine kinase receptor inhibitor , K252a , an inhibitor ( U0126 ) , and a PI3Kinase-Akt inhibitor ( LY294002 ) remarkably *attenuated* TrkB , [ERK] , and Akt phosphorylation as well as increase of OPN mRNA expression in the HCEM cells , respectively . Positive_regulation EPHB2 MAP2K7 24746704 2936463 Here , we found that inhibitors *suppress* [ERK] signaling more potently in BRAF ( V600E ) , than in KRAS mutant tumors . Positive_regulation EPHB2 MAP2K7 8226933 235295 *Activation* of extracellular signal regulated kinase ( [ERK] ) or mitogen activated protein kinase by ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation EPHB2 MAP2K7 8552085 347159 Expression of a dominant interfering mutant , in which lysine 97 was replaced with arginine ( MEK/K97R ) , *resulted* in an inhibition of insulin stimulated SOS and [ERK] phosphorylation , whereas expression of a constitutively active MEK mutant , in which serines 218 and 222 were replaced with glutamic acid ( MEK/EE ) , induced basal phosphorylation of both SOS and ERK . Positive_regulation EPHB2 MAP2K7 9390997 467678 Furthermore , overexpression of a kinase-inactive mutant *inhibited* phorbol ester stimulation of APP secretion and activation of [ERK] in human embryonic kidney cell lines . Positive_regulation EPHB2 MAP2K7 9442025 482992 Arsenite induced [ERK] activation is *mediated* by Ras , Raf , and but appears to be independent of de novo protein synthesis . Positive_regulation EPHB2 MAP2K7 9687508 522242 Consistently , induced [ERK] *activation* in PC12 cells induces c-Jun expression , while JNK signalling does not . Positive_regulation EPHB2 MAP2K7 9826736 550740 Inhibition of ( proximal activator of Erk ) also *blocked* stimulation of [Erk] and adhesion by formylmethionyl-leucyl-phenylalanineand arachidonic acid . Positive_regulation EPHB2 MAP2K7 9864179 582704 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of [ERK] , but not p38 MAPK , induced by G-CSF , GM-CSF , or TNF . Positive_regulation EPHB2 MAP3K1 12600818 1085073 was *required* for maximal activation of [ERK] , JNK , and IKK , as well as for maximal AP-1 and NF-kappaB transcriptional activities . Positive_regulation EPHB2 MAP3K10 9182538 434617 Both MUK/DLK/ZPK and MST/MLK2 cause a slight activation of p38/Mpk2 when overexpressed in COS-1 cells , whereas , but not MUK/DLK/ZPK , *activates* [extracellular response kinase (ERK)] to a certain degree . Positive_regulation EPHB2 MAP3K10 9427749 481741 Transfection of into COS cells *leads* to strong and constitutive activation of the JNK ( c-Jun N-terminal kinase ) MAP kinase cascade , but also to activation of [ERK] ( extracellular signal regulated kinase ) and p38 . Positive_regulation EPHB2 MAP3K11 15258589 1282718 is *required* for mitogen activation of B-Raf , [ERK] and cell proliferation . Positive_regulation EPHB2 MAP3K11 16537381 1536580 We show that the activation of [ERK] and the proliferation of human schwannoma cells bearing a loss-of-function mutation in the neurofibromatosis 2 (NF2) gene *require* . Positive_regulation EPHB2 MAP3K11 16537381 1536583 Thus , is part of a multiprotein complex and is *required* for [ERK] activation . Positive_regulation EPHB2 MAP3K11 21965325 2502767 We observed that functions downstream of FGD1 to *regulate* [ERK] and p38 MAPK , which in turn phosphorylate and activate the master regulator of osteoblast differentiation , Runx2 . Positive_regulation EPHB2 MAP3K12 21893036 2486957 Moreover , RNA interference experiments demonstrate that is *required* for [ERK] activity , expression of the cell cycle regulator cyclin D1 and proliferation of WI-38 cells . Positive_regulation EPHB2 MAP3K12 9182538 434618 Both MUK/DLK/ZPK and MST/MLK2 cause a slight activation of p38/Mpk2 when overexpressed in COS-1 cells , whereas MST/MLK2 , but not , *activates* [extracellular response kinase (ERK)] to a certain degree . Positive_regulation EPHB2 MAP3K13 11549352 856821 When expressed in cardiac myocytes , *activated* SAPK/JNK1 , and [ERK] and p38 to a lesser extent . Positive_regulation EPHB2 MAP3K13 22917630 2683147 inhibition *reduced* [ERK] and JNK , but not p38 , signaling in Caco-2 cells . Positive_regulation EPHB2 MAP3K3 12392720 1007781 However , neither of these phosphorylated amino acids is required for association with 14-3-3 protein or regulation of *dependent* [ERK] and JNK activity . Positive_regulation EPHB2 MAP3K3 12444545 1017455 Stimulation of the conditional mutant Delta : ER* in asynchronous hamster ( CCl39 ) and rat ( Rat-1 ) fibroblasts *resulted* in the strong activation of endogenous JNK and p38 but only a weak activation of [ERK] . Positive_regulation EPHB2 MAP3K3 16407301 1527462 *dependent* activation of an NF-kappaB reporter gene as well as [ERK] , JNK , and p38 MAP kinases correlated with a requirement for serine at position 526 . Positive_regulation EPHB2 MAP3K4 9841871 552928 When truncated ( DeltaMAPKKK4 ) was overexpressed in HEK293 cells , it was constitutively active and *induced* the activation of endogenous p38alpha , c-Jun N-terminal kinase (JNK)1/2 and extracellular signal regulated kinase ( [ERK] ) 2 in vivo . Positive_regulation EPHB2 MAP3K5 15467832 1305796 The expression level and activation of MEK1/2 or [ERK] showed no difference , but the kinase activity of ( ASK1 ) , JNK , or p38 *increased* significantly compared with that in controls . Positive_regulation EPHB2 MAP3K5 8940179 399137 When transiently expressed in COS and 293 cells , markedly *activated* c-Jun N-terminal kinase or stress activated protein kinase , but not [MAPK/ERK] . Positive_regulation EPHB2 MAP3K7 23536866 2762745 Furthermore , our mechanistic studies indicated that NOR obviously suppressed the ubiquitination of TRAF6 , the accumulation of complexes and the *activation* of [ERK] and p38 MAPK , and reduced the nuclear translocation of NF-?B-p65 and DNA binding activity of NF-?B . Positive_regulation EPHB2 MAP3K8 12821717 1104226 These findings indicate that is *essential* for LPS induced [ERK] activation and RANKL induction in osteoblasts . Positive_regulation EPHB2 MAP3K8 15833743 1417999 signals *activate* [ERK] , JNK , and NF-kappaB in a cell-type and stimulus-specific manner . Positive_regulation EPHB2 MAP3K8 17848581 1817812 We have developed a series of highly selective and potent Tpl2 inhibitors , and in the present study we have used these inhibitors to demonstrate that the catalytic activity of is *required* for the LPS induced activation of MEK and [ERK] in primary human monocytes . Positive_regulation EPHB2 MAP3K8 21217011 2386387 NF-?B1 inhibits TLR induced IFN-ß production in macrophages through *dependent* [ERK] activation . Positive_regulation EPHB2 MAP3K8 23252623 2745690 In myeloma tumour cells , acts as mitogen induced MAP3K in mitosis and is *required* for TNFa mediated [ERK] activation . Positive_regulation EPHB2 MAP4K1 17115060 1677217 Here , deficiency *resulted* in enhanced TCR induced phosphorylation of SLP-76 , phospholipase C-gamma1 and the kinase [Erk] , more-persistent calcium flux , and increased production of cytokines and antigen-specific antibodies . Positive_regulation EPHB2 MAPK1 10207619 606841 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by and MEKs , in turn , are regulated by MAPK kinase kinases (MAPKKKs) . Positive_regulation EPHB2 MAPK1 10501195 648309 Inhibition of p38 MAPK had no significant effect on opioid induced ERK activation , indicating that p38 activity was not *required* for [ERK] activation , though its stimulation preceded ERK activation . Positive_regulation EPHB2 MAPK1 10567369 567673 The N-terminal ERK binding site of MEK1 is required for efficient feedback phosphorylation by in vitro and [ERK] *activation* in vivo . Positive_regulation EPHB2 MAPK1 10872747 707009 Pre-treatment of the cells with PD98059 , a selective [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation EPHB2 MAPK1 11360180 816757 These data are consistent with a model where thrombin *induces* [ERK] activation via both PKC dependent and independent pathways , whereas p38 activation requires only PTKs . Positive_regulation EPHB2 MAPK1 11409852 826373 kinase inhibitors PD098059 and U0126 *prevent* [ERK] ( 1/2 ) phosphorylation by Tat . Positive_regulation EPHB2 MAPK1 11546664 856575 The kinase ( MEK ) inhibitors , PD-98059 and U-0126 , *blocked* IL-1 alpha induced [ERK] activation and partially attenuated cPLA(2)alpha phosphorylation and PGI ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation EPHB2 MAPK1 12386816 999747 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 and a biphasic *activation* of [ERK] . Positive_regulation EPHB2 MAPK1 12403788 1036159 SB203580 , a p38 inhibitor , and PD98059 , an [ERK] *inhibitor* , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation EPHB2 MAPK1 12427827 1014770 Although basal levels of activated were elevated in hippocampal extracts from SynGAP ( -/+ ) mice , NMDAR stimulation still *induced* a robust increase in [ERK] activation in slices from SynGAP ( -/+ ) mice . Positive_regulation EPHB2 MAPK1 12450322 1018700 In summary , in H295R cells , ANG II activated [ERK] and p38 MAPKs , ANG II-induced p38 MAPK was mediated by 12-LO activation , and ANG II-induced aldosterone synthesis was *prevented* by 12-LO- and p38 inhibitors . Positive_regulation EPHB2 MAPK1 12460732 1021920 The kinase inhibitor PD 98059 *blocked* palytoxin stimulated [ERK] activation . Positive_regulation EPHB2 MAPK1 12511425 1070721 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation EPHB2 MAPK1 12527329 1048263 The inhibitor U0126 ( 10 microM ) , while *preventing* [ERK] phosphorylation in MDA-MB-468 cells , did not induce apoptosis . Positive_regulation EPHB2 MAPK1 12753285 1089625 Inhibition of PKA by H89 strikingly decreased cAMP stimulated phosphorylation of [ERK] and B-Raf , and inhibition by PD98059 *blocked* the effect of the nucleotide to activate ERK . Positive_regulation EPHB2 MAPK1 12946695 1136841 [ERK] *activation* by the leading to cyclic-AMP response element binding protein ( CREB ) phosphorylation is implicated in the formation of long-term memory . Positive_regulation EPHB2 MAPK1 14514663 1185732 Furthermore , two specific inhibitors ( SP600125 for JNK and UO126 for ERK ) could specifically *block* the activation of JNK and [ERK] and cell transformation . Positive_regulation EPHB2 MAPK1 14647418 1210370 These events were accompanied by the caspase independent downregulation of Raf-1 , inactivation of MEK1/2 , [ERK] , Akt , p70S6K , dephosphorylation of GSK-3 , and *activation* of c-Jun-N-terminal kinase (JNK) and p38 . Positive_regulation EPHB2 MAPK1 14648542 1188334 LPA- and S1P induced [ERK] phosphorylation was *dependent* on the activation of , phospholipase C (PLC) , and protein kinase C ( PKC ) , but was insensitive to pertussis toxin (PTX) . Positive_regulation EPHB2 MAPK1 14973553 1212489 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 MAPK1 14998726 1216713 Furthermore , we found that PD98059 , an [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation EPHB2 MAPK1 15102758 1239906 The inhibition of ERK by the specific inhibitor PD 98059 significantly *reduced* [phospho-ERK44/42] MAPK levels induced by C. albicans supernatant fluids in the IFN-gamma-plus-LPS-driven monocytes . Positive_regulation EPHB2 MAPK1 15147892 1248180 These findings strongly suggest that HHE induces NF-kappaB activation through IKK/NIK pathway and/or p38 and [ERK] *activation* associated with oxidative stress in endothelial cells . Positive_regulation EPHB2 MAPK1 15271999 1296255 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation EPHB2 MAPK1 15659876 1350286 The anabolic effect of TNF-alpha was *mediated* at least in part by , especially by an [extracellular regulated kinases (ERK)] . Positive_regulation EPHB2 MAPK1 16464862 1548072 c-Fos hyperphosphorylation at threonine 325 was found to parallel this p38 *mediated* modulation of [ERK] activation . Positive_regulation EPHB2 MAPK1 16920714 1626734 Overall , our results suggest that intracellular HIV-Tat induces IL-10 transcription by [ERK] *dependent* CREB-1 transcription factor activation through Ser ( 133 ) phosphorylation . Positive_regulation EPHB2 MAPK1 17127048 1732237 In conclusion , ( 1 ) p38MAPK-pathway rather than ERK-pathway may play a more basic role in the regulation of the increased T-bet expression in asthma , and ( 2 ) [ERK-] and p38MAPK-activation modulate IFNgamma expression independently of T-bet and this regulatory role of on IFNgamma release is *impaired* in asthma . Positive_regulation EPHB2 MAPK1 17255201 1725200 Prolactin *induced* phosphorylation of JAK2 and [ERK] , whereas IFN-gamma induced phosphorylation of JAK1 , JAK2 , and p38 . Positive_regulation EPHB2 MAPK1 18164124 1869594 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 , but not by the *activation* of JNK , [ERK] , and NF-kappaB pathway . Positive_regulation EPHB2 MAPK1 18285354 1885390 Pre-treatment with the inhibitors SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( [ERK] *inhibitor* ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation EPHB2 MAPK1 18401006 1925757 CyaA enhanced LPS induced phosphorylation of p38 MAPK and [ERK] in DC , and inhibitors of p38 , MEK , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation EPHB2 MAPK1 18413315 1920476 Furthermore , a inhibitor , PD98059 , *blocked* the eena induced cell proliferation and activation of [ERK] signaling . Positive_regulation EPHB2 MAPK1 18520049 1918657 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of [ERK] , rather than by the *activation* of p38 , in the spinal cord . Positive_regulation EPHB2 MAPK1 19022376 2016959 A inhibitor *reduced* [ERK] phosphorylation in cells with reduced expression of A-type lamins and emerin . Positive_regulation EPHB2 MAPK1 19276187 2051402 Treatment of cells with sphingosine induced suppression of [ERK] and *activation* of p38 . Positive_regulation EPHB2 MAPK1 19416672 2075735 AIH increased BDNF in sham ( 25+/-8 % ; p < 0.05 ) , but not dAIH pretreated rats ( -7+/-4 % ) , and had complex effects on [ERK] phosphorylation ( *increased* in shams whereas ERK1 increased in dAIH treated rats ) . Positive_regulation EPHB2 MAPK1 19429670 2106902 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either [ERK] *inhibitor* , inhibitor or NF-kappaB inhibitor . Positive_regulation EPHB2 MAPK1 19433984 2096488 S1P stimulation of [ERK] was completely *inhibited* by an S1P1/3 subtype receptor antagonist ( VPC23019 ) , by a Gi protein inhibitor ( pertussis toxin ) and by a kinase inhibitor ( PD98059 ) . Positive_regulation EPHB2 MAPK1 19522739 2103125 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation EPHB2 MAPK1 19803745 2232095 Butyrate treatment increased the phosphorylation of [ERK] , not p38 MAPK and JNK , but inhibition of ERK and p38 phosphorylation did not *inhibit* butyrate reduced cell viability . Positive_regulation EPHB2 MAPK1 19879308 2196974 The administration of curcumin led to increased levels of [phosphor-ERK] and AKT , which were each *blocked* by and PI-3K inhibitors . Positive_regulation EPHB2 MAPK1 20025124 2175497 Prior treatment of the cells with PD98059 , an [ERK] kinase *inhibitor* or SB203580 , a inhibitor , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation EPHB2 MAPK1 20406097 2315363 Both overexpression and genetic silencing of PED/PEA-15 by antisense oligonucleotides *increased* [ERK] nuclear accumulation and reduced CAR expression and adenoviral entry . Positive_regulation EPHB2 MAPK1 21126656 2355783 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by [ERK] . Positive_regulation EPHB2 MAPK1 21311676 2360018 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation EPHB2 MAPK1 21488184 2417957 Dexmedetomidine induced phosphorylation of JNK and p38 in rat aortic SMCs , but did not *induce* phosphorylation of [ERK] . Positive_regulation EPHB2 MAPK1 21558315 2445087 The blockade of cAMP *induced* [kinase/ERK] activation abated MKP-1 phosphorylation but only partially reduced flag-MKP-1 protein accumulation . Positive_regulation EPHB2 MAPK1 21720001 2451700 kinase inhibitor , PD98059 ( 10 ( -6 ) M ) , completely *inhibited* the PDGF induced increase in [ERK] activity . Positive_regulation EPHB2 MAPK1 22687715 2669866 Moreover , P. brasiliensis yeasts induced activation of p38 mitogen activated protein kinase (MAPK) , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and extracellular signal regulated kinase ( [ERK] ) 1/2 in A549 cells , and IL-8 and IL-6 secretion promoted by this fungus was *dependent* on activation of p38 and ERK 1/2 . Positive_regulation EPHB2 MAPK1 22843704 2687365 Activation of G ( s ) by ß-adrenergic receptors leads to ( i ) canonical Erk1/2 activation via AC , and ( ii ) release of Gß? , which then associates with activated and *induces* [Erk] ( Thr188 ) phosphorylation , causing nuclear accumulation of Erk and ultimately cardiomyocyte hypertrophy . Positive_regulation EPHB2 MAPK1 23207235 2705340 In addition , the phosphorylation levels of [ERK] and JNK were *induced* in macrophages at 15 min after LPS stimulation , while the phosphorylation level of p38 was induced at 1 h ; Positive_regulation EPHB2 MAPK1 23772367 2714504 VN attenuated radiation induced expression of p21 , an inhibitor of cell cycle progression , and selectively inhibited [Erk-] and p38 *dependent* p21 induction after radiation exposure through regulation of the activity of GSK-3ß . Positive_regulation EPHB2 MAPK1 23811561 2808179 [ERK] *activation* by over-expression of constitutively active ( MEK1 ) strongly increased GATA-4 phosphorylation and its protein levels and decreased GATA-4 ubiquitination under hypoxia . Positive_regulation EPHB2 MAPK1 23892041 2830319 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three inhibitors ( [ERK] inhibitor PD98059 , JNK inhibitor SP600125 and p38 *inhibitor* SB203580 ) . Positive_regulation EPHB2 MAPK1 23914844 2840555 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of [ERK] , JNK , NF-?B . Positive_regulation EPHB2 MAPK1 24225419 2897479 Therefore , by using the inhibitors SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific [ERK] *inhibitor* ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation EPHB2 MAPK1 24297112 2894198 Following treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation EPHB2 MAPK1 8843216 387374 Differential *activation* of extracellular signal regulated kinase ( [ERK] ) 1 , , p38 , and c-Jun NH2-terminal kinase mitogen activated protein kinases by bacterial peptidoglycan . Positive_regulation EPHB2 MAPK10 10207619 606842 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by and MEKs , in turn , are regulated by MAPK kinase kinases (MAPKKKs) . Positive_regulation EPHB2 MAPK10 10501195 648310 Inhibition of p38 MAPK had no significant effect on opioid induced ERK activation , indicating that p38 activity was not *required* for [ERK] activation , though its stimulation preceded ERK activation . Positive_regulation EPHB2 MAPK10 10872747 707010 Pre-treatment of the cells with PD98059 , a selective [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation EPHB2 MAPK10 11360180 816758 These data are consistent with a model where thrombin *induces* [ERK] activation via both PKC dependent and independent pathways , whereas p38 activation requires only PTKs . Positive_regulation EPHB2 MAPK10 11409852 826374 kinase inhibitors PD098059 and U0126 *prevent* [ERK] ( 1/2 ) phosphorylation by Tat . Positive_regulation EPHB2 MAPK10 11546664 856576 The kinase ( MEK ) inhibitors , PD-98059 and U-0126 , *blocked* IL-1 alpha induced [ERK] activation and partially attenuated cPLA(2)alpha phosphorylation and PGI ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation EPHB2 MAPK10 12386816 999748 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 and a biphasic *activation* of [ERK] . Positive_regulation EPHB2 MAPK10 12403788 1036160 SB203580 , a p38 inhibitor , and PD98059 , an [ERK] *inhibitor* , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation EPHB2 MAPK10 12450322 1018701 In summary , in H295R cells , ANG II activated [ERK] and p38 MAPKs , ANG II-induced p38 MAPK was mediated by 12-LO activation , and ANG II-induced aldosterone synthesis was *prevented* by 12-LO- and p38 inhibitors . Positive_regulation EPHB2 MAPK10 12460732 1021921 The kinase inhibitor PD 98059 *blocked* palytoxin stimulated [ERK] activation . Positive_regulation EPHB2 MAPK10 12511425 1070722 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation EPHB2 MAPK10 12527329 1048264 The inhibitor U0126 ( 10 microM ) , while *preventing* [ERK] phosphorylation in MDA-MB-468 cells , did not induce apoptosis . Positive_regulation EPHB2 MAPK10 12753285 1089626 Inhibition of PKA by H89 strikingly decreased cAMP stimulated phosphorylation of [ERK] and B-Raf , and inhibition by PD98059 *blocked* the effect of the nucleotide to activate ERK . Positive_regulation EPHB2 MAPK10 12946695 1136842 [ERK] *activation* by the leading to cyclic-AMP response element binding protein ( CREB ) phosphorylation is implicated in the formation of long-term memory . Positive_regulation EPHB2 MAPK10 14514663 1185733 Furthermore , two specific inhibitors ( SP600125 for JNK and UO126 for ERK ) could specifically *block* the activation of JNK and [ERK] and cell transformation . Positive_regulation EPHB2 MAPK10 14647418 1210371 These events were accompanied by the caspase independent downregulation of Raf-1 , inactivation of MEK1/2 , [ERK] , Akt , p70S6K , dephosphorylation of GSK-3 , and *activation* of c-Jun-N-terminal kinase (JNK) and p38 . Positive_regulation EPHB2 MAPK10 14648542 1188335 LPA- and S1P induced [ERK] phosphorylation was *dependent* on the activation of , phospholipase C (PLC) , and protein kinase C ( PKC ) , but was insensitive to pertussis toxin (PTX) . Positive_regulation EPHB2 MAPK10 14973553 1212490 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 MAPK10 14998726 1216714 Furthermore , we found that PD98059 , an [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation EPHB2 MAPK10 15102758 1239907 The inhibition of ERK by the specific inhibitor PD 98059 significantly *reduced* [phospho-ERK44/42] MAPK levels induced by C. albicans supernatant fluids in the IFN-gamma-plus-LPS-driven monocytes . Positive_regulation EPHB2 MAPK10 15147892 1248181 These findings strongly suggest that HHE induces NF-kappaB activation through IKK/NIK pathway and/or p38 and [ERK] *activation* associated with oxidative stress in endothelial cells . Positive_regulation EPHB2 MAPK10 15271999 1296256 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation EPHB2 MAPK10 15659876 1350287 The anabolic effect of TNF-alpha was *mediated* at least in part by , especially by an [extracellular regulated kinases (ERK)] . Positive_regulation EPHB2 MAPK10 16464862 1548073 c-Fos hyperphosphorylation at threonine 325 was found to parallel this p38 *mediated* modulation of [ERK] activation . Positive_regulation EPHB2 MAPK10 16920714 1626735 Overall , our results suggest that intracellular HIV-Tat induces IL-10 transcription by [ERK] dependent CREB-1 transcription factor *activation* through Ser ( 133 ) phosphorylation . Positive_regulation EPHB2 MAPK10 17255201 1725201 Prolactin *induced* phosphorylation of JAK2 and [ERK] , whereas IFN-gamma induced phosphorylation of JAK1 , JAK2 , and p38 . Positive_regulation EPHB2 MAPK10 18164124 1869595 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 , but not by the *activation* of JNK , [ERK] , and NF-kappaB pathway . Positive_regulation EPHB2 MAPK10 18285354 1885391 Pre-treatment with the inhibitors SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( [ERK] *inhibitor* ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation EPHB2 MAPK10 18401006 1925758 CyaA enhanced LPS induced phosphorylation of p38 MAPK and [ERK] in DC , and inhibitors of p38 , MEK , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation EPHB2 MAPK10 18413315 1920477 Furthermore , a inhibitor , PD98059 , *blocked* the eena induced cell proliferation and activation of [ERK] signaling . Positive_regulation EPHB2 MAPK10 18520049 1918658 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of [ERK] , rather than by the *activation* of p38 , in the spinal cord . Positive_regulation EPHB2 MAPK10 19022376 2016960 A inhibitor *reduced* [ERK] phosphorylation in cells with reduced expression of A-type lamins and emerin . Positive_regulation EPHB2 MAPK10 19276187 2051403 Treatment of cells with sphingosine induced suppression of [ERK] and *activation* of p38 . Positive_regulation EPHB2 MAPK10 19429670 2106903 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either [ERK] *inhibitor* , inhibitor or NF-kappaB inhibitor . Positive_regulation EPHB2 MAPK10 19433984 2096489 S1P stimulation of [ERK] was completely *inhibited* by an S1P1/3 subtype receptor antagonist ( VPC23019 ) , by a Gi protein inhibitor ( pertussis toxin ) and by a kinase inhibitor ( PD98059 ) . Positive_regulation EPHB2 MAPK10 19522739 2103126 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation EPHB2 MAPK10 19803745 2232096 Butyrate treatment increased the phosphorylation of [ERK] , not p38 MAPK and JNK , but inhibition of ERK and p38 phosphorylation did not *inhibit* butyrate reduced cell viability . Positive_regulation EPHB2 MAPK10 19879308 2196975 The administration of curcumin led to increased levels of [phosphor-ERK] and AKT , which were each *blocked* by and PI-3K inhibitors . Positive_regulation EPHB2 MAPK10 20025124 2175498 Prior treatment of the cells with PD98059 , an [ERK] kinase *inhibitor* or SB203580 , a inhibitor , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation EPHB2 MAPK10 21126656 2355784 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by [ERK] . Positive_regulation EPHB2 MAPK10 21311676 2360019 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation EPHB2 MAPK10 21488184 2417958 Dexmedetomidine induced phosphorylation of JNK and p38 in rat aortic SMCs , but did not *induce* phosphorylation of [ERK] . Positive_regulation EPHB2 MAPK10 21558315 2445088 The blockade of cAMP *induced* [kinase/ERK] activation abated MKP-1 phosphorylation but only partially reduced flag-MKP-1 protein accumulation . Positive_regulation EPHB2 MAPK10 21720001 2451701 kinase inhibitor , PD98059 ( 10 ( -6 ) M ) , completely *inhibited* the PDGF induced increase in [ERK] activity . Positive_regulation EPHB2 MAPK10 22687715 2669867 Moreover , P. brasiliensis yeasts induced activation of p38 mitogen activated protein kinase (MAPK) , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and extracellular signal regulated kinase ( [ERK] ) 1/2 in A549 cells , and IL-8 and IL-6 secretion promoted by this fungus was *dependent* on activation of p38 and ERK 1/2 . Positive_regulation EPHB2 MAPK10 23207235 2705341 In addition , the phosphorylation levels of [ERK] and JNK were *induced* in macrophages at 15 min after LPS stimulation , while the phosphorylation level of p38 was induced at 1 h ; Positive_regulation EPHB2 MAPK10 23772367 2714505 VN attenuated radiation induced expression of p21 , an inhibitor of cell cycle progression , and selectively inhibited [Erk-] and p38 dependent p21 *induction* after radiation exposure through regulation of the activity of GSK-3ß . Positive_regulation EPHB2 MAPK10 23892041 2830320 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three inhibitors ( [ERK] inhibitor PD98059 , JNK inhibitor SP600125 and p38 *inhibitor* SB203580 ) . Positive_regulation EPHB2 MAPK10 23914844 2840556 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of [ERK] , JNK , NF-?B . Positive_regulation EPHB2 MAPK10 24225419 2897480 Therefore , by using the inhibitors SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific [ERK] *inhibitor* ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation EPHB2 MAPK10 24297112 2894199 Following treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation EPHB2 MAPK11 10207619 606843 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by and MEKs , in turn , are regulated by MAPK kinase kinases (MAPKKKs) . Positive_regulation EPHB2 MAPK11 10501195 648311 Inhibition of p38 MAPK had no significant effect on opioid induced ERK activation , indicating that p38 activity was not *required* for [ERK] activation , though its stimulation preceded ERK activation . Positive_regulation EPHB2 MAPK11 10872747 707011 Pre-treatment of the cells with PD98059 , a selective [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation EPHB2 MAPK11 11360180 816759 These data are consistent with a model where thrombin *induces* [ERK] activation via both PKC dependent and independent pathways , whereas p38 activation requires only PTKs . Positive_regulation EPHB2 MAPK11 11409852 826375 kinase inhibitors PD098059 and U0126 *prevent* [ERK] ( 1/2 ) phosphorylation by Tat . Positive_regulation EPHB2 MAPK11 11546664 856577 The kinase ( MEK ) inhibitors , PD-98059 and U-0126 , *blocked* IL-1 alpha induced [ERK] activation and partially attenuated cPLA(2)alpha phosphorylation and PGI ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation EPHB2 MAPK11 12386816 999749 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 and a biphasic *activation* of [ERK] . Positive_regulation EPHB2 MAPK11 12403788 1036161 SB203580 , a p38 inhibitor , and PD98059 , an [ERK] *inhibitor* , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation EPHB2 MAPK11 12450322 1018702 In summary , in H295R cells , ANG II activated [ERK] and p38 MAPKs , ANG II-induced p38 MAPK was mediated by 12-LO activation , and ANG II-induced aldosterone synthesis was *prevented* by 12-LO- and p38 inhibitors . Positive_regulation EPHB2 MAPK11 12460732 1021922 The kinase inhibitor PD 98059 *blocked* palytoxin stimulated [ERK] activation . Positive_regulation EPHB2 MAPK11 12511425 1070723 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation EPHB2 MAPK11 12527329 1048265 The inhibitor U0126 ( 10 microM ) , while *preventing* [ERK] phosphorylation in MDA-MB-468 cells , did not induce apoptosis . Positive_regulation EPHB2 MAPK11 12753285 1089627 Inhibition of PKA by H89 strikingly decreased cAMP stimulated phosphorylation of [ERK] and B-Raf , and inhibition by PD98059 *blocked* the effect of the nucleotide to activate ERK . Positive_regulation EPHB2 MAPK11 12946695 1136843 [ERK] *activation* by the leading to cyclic-AMP response element binding protein ( CREB ) phosphorylation is implicated in the formation of long-term memory . Positive_regulation EPHB2 MAPK11 14514663 1185734 Furthermore , two specific inhibitors ( SP600125 for JNK and UO126 for ERK ) could specifically *block* the activation of JNK and [ERK] and cell transformation . Positive_regulation EPHB2 MAPK11 14647418 1210372 These events were accompanied by the caspase independent downregulation of Raf-1 , inactivation of MEK1/2 , [ERK] , Akt , p70S6K , dephosphorylation of GSK-3 , and *activation* of c-Jun-N-terminal kinase (JNK) and p38 . Positive_regulation EPHB2 MAPK11 14648542 1188336 LPA- and S1P induced [ERK] phosphorylation was *dependent* on the activation of , phospholipase C (PLC) , and protein kinase C ( PKC ) , but was insensitive to pertussis toxin (PTX) . Positive_regulation EPHB2 MAPK11 14973553 1212491 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 MAPK11 14998726 1216715 Furthermore , we found that PD98059 , an [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation EPHB2 MAPK11 15102758 1239908 The inhibition of ERK by the specific inhibitor PD 98059 significantly *reduced* [phospho-ERK44/42] MAPK levels induced by C. albicans supernatant fluids in the IFN-gamma-plus-LPS-driven monocytes . Positive_regulation EPHB2 MAPK11 15147892 1248182 These findings strongly suggest that HHE induces NF-kappaB activation through IKK/NIK pathway and/or p38 and [ERK] *activation* associated with oxidative stress in endothelial cells . Positive_regulation EPHB2 MAPK11 15271999 1296257 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation EPHB2 MAPK11 15659876 1350288 The anabolic effect of TNF-alpha was *mediated* at least in part by , especially by an [extracellular regulated kinases (ERK)] . Positive_regulation EPHB2 MAPK11 16464862 1548074 c-Fos hyperphosphorylation at threonine 325 was found to parallel this p38 *mediated* modulation of [ERK] activation . Positive_regulation EPHB2 MAPK11 16920714 1626736 Overall , our results suggest that intracellular HIV-Tat induces IL-10 transcription by [ERK] *dependent* CREB-1 transcription factor activation through Ser ( 133 ) phosphorylation . Positive_regulation EPHB2 MAPK11 17255201 1725202 Prolactin *induced* phosphorylation of JAK2 and [ERK] , whereas IFN-gamma induced phosphorylation of JAK1 , JAK2 , and p38 . Positive_regulation EPHB2 MAPK11 18164124 1869596 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 , but not by the *activation* of JNK , [ERK] , and NF-kappaB pathway . Positive_regulation EPHB2 MAPK11 18285354 1885392 Pre-treatment with the inhibitors SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( [ERK] *inhibitor* ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation EPHB2 MAPK11 18401006 1925759 CyaA enhanced LPS induced phosphorylation of p38 MAPK and [ERK] in DC , and inhibitors of p38 , MEK , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation EPHB2 MAPK11 18413315 1920478 Furthermore , a inhibitor , PD98059 , *blocked* the eena induced cell proliferation and activation of [ERK] signaling . Positive_regulation EPHB2 MAPK11 18520049 1918659 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of [ERK] , rather than by the *activation* of p38 , in the spinal cord . Positive_regulation EPHB2 MAPK11 19022376 2016961 A inhibitor *reduced* [ERK] phosphorylation in cells with reduced expression of A-type lamins and emerin . Positive_regulation EPHB2 MAPK11 19276187 2051404 Treatment of cells with sphingosine induced suppression of [ERK] and *activation* of p38 . Positive_regulation EPHB2 MAPK11 19429670 2106904 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either [ERK] *inhibitor* , inhibitor or NF-kappaB inhibitor . Positive_regulation EPHB2 MAPK11 19433984 2096490 S1P stimulation of [ERK] was completely *inhibited* by an S1P1/3 subtype receptor antagonist ( VPC23019 ) , by a Gi protein inhibitor ( pertussis toxin ) and by a kinase inhibitor ( PD98059 ) . Positive_regulation EPHB2 MAPK11 19522739 2103127 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation EPHB2 MAPK11 19803745 2232097 Butyrate treatment increased the phosphorylation of [ERK] , not p38 MAPK and JNK , but inhibition of ERK and p38 phosphorylation did not *inhibit* butyrate reduced cell viability . Positive_regulation EPHB2 MAPK11 19879308 2196976 The administration of curcumin led to increased levels of [phosphor-ERK] and AKT , which were each *blocked* by and PI-3K inhibitors . Positive_regulation EPHB2 MAPK11 20025124 2175499 Prior treatment of the cells with PD98059 , an [ERK] kinase *inhibitor* or SB203580 , a inhibitor , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation EPHB2 MAPK11 21126656 2355785 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by [ERK] . Positive_regulation EPHB2 MAPK11 21311676 2360020 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation EPHB2 MAPK11 21488184 2417959 Dexmedetomidine induced phosphorylation of JNK and p38 in rat aortic SMCs , but did not *induce* phosphorylation of [ERK] . Positive_regulation EPHB2 MAPK11 21558315 2445089 The blockade of cAMP *induced* [kinase/ERK] activation abated MKP-1 phosphorylation but only partially reduced flag-MKP-1 protein accumulation . Positive_regulation EPHB2 MAPK11 21720001 2451702 kinase inhibitor , PD98059 ( 10 ( -6 ) M ) , completely *inhibited* the PDGF induced increase in [ERK] activity . Positive_regulation EPHB2 MAPK11 22687715 2669868 Moreover , P. brasiliensis yeasts induced activation of p38 mitogen activated protein kinase (MAPK) , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and extracellular signal regulated kinase ( [ERK] ) 1/2 in A549 cells , and IL-8 and IL-6 secretion promoted by this fungus was *dependent* on activation of p38 and ERK 1/2 . Positive_regulation EPHB2 MAPK11 23207235 2705342 In addition , the phosphorylation levels of [ERK] and JNK were *induced* in macrophages at 15 min after LPS stimulation , while the phosphorylation level of p38 was induced at 1 h ; Positive_regulation EPHB2 MAPK11 23772367 2714506 VN attenuated radiation induced expression of p21 , an inhibitor of cell cycle progression , and selectively inhibited [Erk-] and p38 *dependent* p21 induction after radiation exposure through regulation of the activity of GSK-3ß . Positive_regulation EPHB2 MAPK11 23892041 2830321 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three inhibitors ( [ERK] inhibitor PD98059 , JNK inhibitor SP600125 and p38 *inhibitor* SB203580 ) . Positive_regulation EPHB2 MAPK11 23914844 2840557 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of [ERK] , JNK , NF-?B . Positive_regulation EPHB2 MAPK11 24225419 2897481 Therefore , by using the inhibitors SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific [ERK] *inhibitor* ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation EPHB2 MAPK11 24297112 2894200 Following treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation EPHB2 MAPK11 9832563 551919 Cis-platinum , which activated but *induced* little [ERK] activity , also induced membrane blebbing that was dependent on the expression of HSP27 . Positive_regulation EPHB2 MAPK12 10207619 606844 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by and MEKs , in turn , are regulated by MAPK kinase kinases (MAPKKKs) . Positive_regulation EPHB2 MAPK12 10501195 648312 Inhibition of p38 MAPK had no significant effect on opioid induced ERK activation , indicating that p38 activity was not *required* for [ERK] activation , though its stimulation preceded ERK activation . Positive_regulation EPHB2 MAPK12 10872747 707012 Pre-treatment of the cells with PD98059 , a selective [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation EPHB2 MAPK12 11360180 816760 These data are consistent with a model where thrombin *induces* [ERK] activation via both PKC dependent and independent pathways , whereas p38 activation requires only PTKs . Positive_regulation EPHB2 MAPK12 11409852 826376 kinase inhibitors PD098059 and U0126 *prevent* [ERK] ( 1/2 ) phosphorylation by Tat . Positive_regulation EPHB2 MAPK12 11546664 856578 The kinase ( MEK ) inhibitors , PD-98059 and U-0126 , *blocked* IL-1 alpha induced [ERK] activation and partially attenuated cPLA(2)alpha phosphorylation and PGI ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation EPHB2 MAPK12 12386816 999750 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 and a biphasic *activation* of [ERK] . Positive_regulation EPHB2 MAPK12 12403788 1036162 SB203580 , a p38 inhibitor , and PD98059 , an [ERK] *inhibitor* , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation EPHB2 MAPK12 12450322 1018703 In summary , in H295R cells , ANG II activated [ERK] and p38 MAPKs , ANG II-induced p38 MAPK was mediated by 12-LO activation , and ANG II-induced aldosterone synthesis was *prevented* by 12-LO- and p38 inhibitors . Positive_regulation EPHB2 MAPK12 12460732 1021923 The kinase inhibitor PD 98059 *blocked* palytoxin stimulated [ERK] activation . Positive_regulation EPHB2 MAPK12 12511425 1070724 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation EPHB2 MAPK12 12527329 1048266 The inhibitor U0126 ( 10 microM ) , while *preventing* [ERK] phosphorylation in MDA-MB-468 cells , did not induce apoptosis . Positive_regulation EPHB2 MAPK12 12753285 1089628 Inhibition of PKA by H89 strikingly decreased cAMP stimulated phosphorylation of [ERK] and B-Raf , and inhibition by PD98059 *blocked* the effect of the nucleotide to activate ERK . Positive_regulation EPHB2 MAPK12 12946695 1136844 [ERK] *activation* by the leading to cyclic-AMP response element binding protein ( CREB ) phosphorylation is implicated in the formation of long-term memory . Positive_regulation EPHB2 MAPK12 14514663 1185735 Furthermore , two specific inhibitors ( SP600125 for JNK and UO126 for ERK ) could specifically *block* the activation of JNK and [ERK] and cell transformation . Positive_regulation EPHB2 MAPK12 14647418 1210373 These events were accompanied by the caspase independent downregulation of Raf-1 , inactivation of MEK1/2 , [ERK] , Akt , p70S6K , dephosphorylation of GSK-3 , and *activation* of c-Jun-N-terminal kinase (JNK) and p38 . Positive_regulation EPHB2 MAPK12 14648542 1188337 LPA- and S1P induced [ERK] phosphorylation was *dependent* on the activation of , phospholipase C (PLC) , and protein kinase C ( PKC ) , but was insensitive to pertussis toxin (PTX) . Positive_regulation EPHB2 MAPK12 14973553 1212492 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 MAPK12 14998726 1216716 Furthermore , we found that PD98059 , an [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation EPHB2 MAPK12 15102758 1239909 The inhibition of ERK by the specific inhibitor PD 98059 significantly *reduced* [phospho-ERK44/42] MAPK levels induced by C. albicans supernatant fluids in the IFN-gamma-plus-LPS-driven monocytes . Positive_regulation EPHB2 MAPK12 15147892 1248183 These findings strongly suggest that HHE induces NF-kappaB activation through IKK/NIK pathway and/or p38 and [ERK] *activation* associated with oxidative stress in endothelial cells . Positive_regulation EPHB2 MAPK12 15271999 1296258 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation EPHB2 MAPK12 15659876 1350289 The anabolic effect of TNF-alpha was *mediated* at least in part by , especially by an [extracellular regulated kinases (ERK)] . Positive_regulation EPHB2 MAPK12 16464862 1548075 c-Fos hyperphosphorylation at threonine 325 was found to parallel this p38 *mediated* modulation of [ERK] activation . Positive_regulation EPHB2 MAPK12 16920714 1626737 Overall , our results suggest that intracellular HIV-Tat induces IL-10 transcription by [ERK] dependent CREB-1 transcription factor *activation* through Ser ( 133 ) phosphorylation . Positive_regulation EPHB2 MAPK12 17255201 1725203 Prolactin *induced* phosphorylation of JAK2 and [ERK] , whereas IFN-gamma induced phosphorylation of JAK1 , JAK2 , and p38 . Positive_regulation EPHB2 MAPK12 18164124 1869597 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 , but not by the *activation* of JNK , [ERK] , and NF-kappaB pathway . Positive_regulation EPHB2 MAPK12 18285354 1885393 Pre-treatment with the inhibitors SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( [ERK] *inhibitor* ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation EPHB2 MAPK12 18401006 1925760 CyaA enhanced LPS induced phosphorylation of p38 MAPK and [ERK] in DC , and inhibitors of p38 , MEK , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation EPHB2 MAPK12 18413315 1920479 Furthermore , a inhibitor , PD98059 , *blocked* the eena induced cell proliferation and activation of [ERK] signaling . Positive_regulation EPHB2 MAPK12 18520049 1918660 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of [ERK] , rather than by the *activation* of p38 , in the spinal cord . Positive_regulation EPHB2 MAPK12 19022376 2016962 A inhibitor *reduced* [ERK] phosphorylation in cells with reduced expression of A-type lamins and emerin . Positive_regulation EPHB2 MAPK12 19276187 2051405 Treatment of cells with sphingosine induced suppression of [ERK] and *activation* of p38 . Positive_regulation EPHB2 MAPK12 19429670 2106905 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either [ERK] *inhibitor* , inhibitor or NF-kappaB inhibitor . Positive_regulation EPHB2 MAPK12 19433984 2096491 S1P stimulation of [ERK] was completely *inhibited* by an S1P1/3 subtype receptor antagonist ( VPC23019 ) , by a Gi protein inhibitor ( pertussis toxin ) and by a kinase inhibitor ( PD98059 ) . Positive_regulation EPHB2 MAPK12 19522739 2103128 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation EPHB2 MAPK12 19803745 2232098 Butyrate treatment increased the phosphorylation of [ERK] , not p38 MAPK and JNK , but inhibition of ERK and p38 phosphorylation did not *inhibit* butyrate reduced cell viability . Positive_regulation EPHB2 MAPK12 19879308 2196977 The administration of curcumin led to increased levels of [phosphor-ERK] and AKT , which were each *blocked* by and PI-3K inhibitors . Positive_regulation EPHB2 MAPK12 20025124 2175500 Prior treatment of the cells with PD98059 , an [ERK] kinase *inhibitor* or SB203580 , a inhibitor , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation EPHB2 MAPK12 21126656 2355786 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by [ERK] . Positive_regulation EPHB2 MAPK12 21311676 2360021 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation EPHB2 MAPK12 21488184 2417960 Dexmedetomidine induced phosphorylation of JNK and p38 in rat aortic SMCs , but did not *induce* phosphorylation of [ERK] . Positive_regulation EPHB2 MAPK12 21558315 2445090 The blockade of cAMP *induced* [kinase/ERK] activation abated MKP-1 phosphorylation but only partially reduced flag-MKP-1 protein accumulation . Positive_regulation EPHB2 MAPK12 21720001 2451703 kinase inhibitor , PD98059 ( 10 ( -6 ) M ) , completely *inhibited* the PDGF induced increase in [ERK] activity . Positive_regulation EPHB2 MAPK12 22687715 2669869 Moreover , P. brasiliensis yeasts induced activation of p38 mitogen activated protein kinase (MAPK) , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and extracellular signal regulated kinase ( [ERK] ) 1/2 in A549 cells , and IL-8 and IL-6 secretion promoted by this fungus was *dependent* on activation of p38 and ERK 1/2 . Positive_regulation EPHB2 MAPK12 23207235 2705343 In addition , the phosphorylation levels of [ERK] and JNK were *induced* in macrophages at 15 min after LPS stimulation , while the phosphorylation level of p38 was induced at 1 h ; Positive_regulation EPHB2 MAPK12 23772367 2714507 VN attenuated radiation induced expression of p21 , an inhibitor of cell cycle progression , and selectively inhibited [Erk-] and p38 dependent p21 *induction* after radiation exposure through regulation of the activity of GSK-3ß . Positive_regulation EPHB2 MAPK12 23892041 2830322 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three inhibitors ( [ERK] inhibitor PD98059 , JNK inhibitor SP600125 and p38 *inhibitor* SB203580 ) . Positive_regulation EPHB2 MAPK12 23914844 2840558 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of [ERK] , JNK , NF-?B . Positive_regulation EPHB2 MAPK12 24225419 2897482 Therefore , by using the inhibitors SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific [ERK] *inhibitor* ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation EPHB2 MAPK12 24297112 2894201 Following treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation EPHB2 MAPK13 10207619 606845 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by and MEKs , in turn , are regulated by MAPK kinase kinases (MAPKKKs) . Positive_regulation EPHB2 MAPK13 10501195 648313 Inhibition of p38 MAPK had no significant effect on opioid induced ERK activation , indicating that p38 activity was not *required* for [ERK] activation , though its stimulation preceded ERK activation . Positive_regulation EPHB2 MAPK13 10872747 707013 Pre-treatment of the cells with PD98059 , a selective [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation EPHB2 MAPK13 11360180 816761 These data are consistent with a model where thrombin *induces* [ERK] activation via both PKC dependent and independent pathways , whereas p38 activation requires only PTKs . Positive_regulation EPHB2 MAPK13 11409852 826377 kinase inhibitors PD098059 and U0126 *prevent* [ERK] ( 1/2 ) phosphorylation by Tat . Positive_regulation EPHB2 MAPK13 11546664 856579 The kinase ( MEK ) inhibitors , PD-98059 and U-0126 , *blocked* IL-1 alpha induced [ERK] activation and partially attenuated cPLA(2)alpha phosphorylation and PGI ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation EPHB2 MAPK13 12386816 999751 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 and a biphasic *activation* of [ERK] . Positive_regulation EPHB2 MAPK13 12403788 1036163 SB203580 , a p38 inhibitor , and PD98059 , an [ERK] *inhibitor* , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation EPHB2 MAPK13 12450322 1018704 In summary , in H295R cells , ANG II activated [ERK] and p38 MAPKs , ANG II-induced p38 MAPK was mediated by 12-LO activation , and ANG II-induced aldosterone synthesis was *prevented* by 12-LO- and p38 inhibitors . Positive_regulation EPHB2 MAPK13 12460732 1021924 The kinase inhibitor PD 98059 *blocked* palytoxin stimulated [ERK] activation . Positive_regulation EPHB2 MAPK13 12511425 1070725 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation EPHB2 MAPK13 12527329 1048267 The inhibitor U0126 ( 10 microM ) , while *preventing* [ERK] phosphorylation in MDA-MB-468 cells , did not induce apoptosis . Positive_regulation EPHB2 MAPK13 12753285 1089629 Inhibition of PKA by H89 strikingly decreased cAMP stimulated phosphorylation of [ERK] and B-Raf , and inhibition by PD98059 *blocked* the effect of the nucleotide to activate ERK . Positive_regulation EPHB2 MAPK13 12946695 1136845 [ERK] *activation* by the leading to cyclic-AMP response element binding protein ( CREB ) phosphorylation is implicated in the formation of long-term memory . Positive_regulation EPHB2 MAPK13 14514663 1185736 Furthermore , two specific inhibitors ( SP600125 for JNK and UO126 for ERK ) could specifically *block* the activation of JNK and [ERK] and cell transformation . Positive_regulation EPHB2 MAPK13 14647418 1210374 These events were accompanied by the caspase independent downregulation of Raf-1 , inactivation of MEK1/2 , [ERK] , Akt , p70S6K , dephosphorylation of GSK-3 , and *activation* of c-Jun-N-terminal kinase (JNK) and p38 . Positive_regulation EPHB2 MAPK13 14648542 1188338 LPA- and S1P induced [ERK] phosphorylation was *dependent* on the activation of , phospholipase C (PLC) , and protein kinase C ( PKC ) , but was insensitive to pertussis toxin (PTX) . Positive_regulation EPHB2 MAPK13 14973553 1212493 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 MAPK13 14998726 1216717 Furthermore , we found that PD98059 , an [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation EPHB2 MAPK13 15102758 1239910 The inhibition of ERK by the specific inhibitor PD 98059 significantly *reduced* [phospho-ERK44/42] MAPK levels induced by C. albicans supernatant fluids in the IFN-gamma-plus-LPS-driven monocytes . Positive_regulation EPHB2 MAPK13 15147892 1248184 These findings strongly suggest that HHE induces NF-kappaB activation through IKK/NIK pathway and/or p38 and [ERK] *activation* associated with oxidative stress in endothelial cells . Positive_regulation EPHB2 MAPK13 15271999 1296259 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation EPHB2 MAPK13 15659876 1350290 The anabolic effect of TNF-alpha was *mediated* at least in part by , especially by an [extracellular regulated kinases (ERK)] . Positive_regulation EPHB2 MAPK13 16464862 1548076 c-Fos hyperphosphorylation at threonine 325 was found to parallel this p38 *mediated* modulation of [ERK] activation . Positive_regulation EPHB2 MAPK13 16920714 1626738 Overall , our results suggest that intracellular HIV-Tat induces IL-10 transcription by [ERK] *dependent* CREB-1 transcription factor activation through Ser ( 133 ) phosphorylation . Positive_regulation EPHB2 MAPK13 17255201 1725204 Prolactin *induced* phosphorylation of JAK2 and [ERK] , whereas IFN-gamma induced phosphorylation of JAK1 , JAK2 , and p38 . Positive_regulation EPHB2 MAPK13 18164124 1869598 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 , but not by the *activation* of JNK , [ERK] , and NF-kappaB pathway . Positive_regulation EPHB2 MAPK13 18285354 1885394 Pre-treatment with the inhibitors SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( [ERK] *inhibitor* ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation EPHB2 MAPK13 18401006 1925761 CyaA enhanced LPS induced phosphorylation of p38 MAPK and [ERK] in DC , and inhibitors of p38 , MEK , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation EPHB2 MAPK13 18413315 1920480 Furthermore , a inhibitor , PD98059 , *blocked* the eena induced cell proliferation and activation of [ERK] signaling . Positive_regulation EPHB2 MAPK13 18520049 1918661 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of [ERK] , rather than by the *activation* of p38 , in the spinal cord . Positive_regulation EPHB2 MAPK13 19022376 2016963 A inhibitor *reduced* [ERK] phosphorylation in cells with reduced expression of A-type lamins and emerin . Positive_regulation EPHB2 MAPK13 19276187 2051406 Treatment of cells with sphingosine induced suppression of [ERK] and *activation* of p38 . Positive_regulation EPHB2 MAPK13 19429670 2106906 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either [ERK] *inhibitor* , inhibitor or NF-kappaB inhibitor . Positive_regulation EPHB2 MAPK13 19433984 2096492 S1P stimulation of [ERK] was completely *inhibited* by an S1P1/3 subtype receptor antagonist ( VPC23019 ) , by a Gi protein inhibitor ( pertussis toxin ) and by a kinase inhibitor ( PD98059 ) . Positive_regulation EPHB2 MAPK13 19522739 2103129 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation EPHB2 MAPK13 19803745 2232099 Butyrate treatment increased the phosphorylation of [ERK] , not p38 MAPK and JNK , but inhibition of ERK and p38 phosphorylation did not *inhibit* butyrate reduced cell viability . Positive_regulation EPHB2 MAPK13 19879308 2196978 The administration of curcumin led to increased levels of [phosphor-ERK] and AKT , which were each *blocked* by and PI-3K inhibitors . Positive_regulation EPHB2 MAPK13 20025124 2175501 Prior treatment of the cells with PD98059 , an [ERK] kinase *inhibitor* or SB203580 , a inhibitor , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation EPHB2 MAPK13 21126656 2355787 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by [ERK] . Positive_regulation EPHB2 MAPK13 21311676 2360022 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation EPHB2 MAPK13 21488184 2417961 Dexmedetomidine induced phosphorylation of JNK and p38 in rat aortic SMCs , but did not *induce* phosphorylation of [ERK] . Positive_regulation EPHB2 MAPK13 21558315 2445091 The blockade of cAMP *induced* [kinase/ERK] activation abated MKP-1 phosphorylation but only partially reduced flag-MKP-1 protein accumulation . Positive_regulation EPHB2 MAPK13 21720001 2451704 kinase inhibitor , PD98059 ( 10 ( -6 ) M ) , completely *inhibited* the PDGF induced increase in [ERK] activity . Positive_regulation EPHB2 MAPK13 22687715 2669870 Moreover , P. brasiliensis yeasts induced activation of p38 mitogen activated protein kinase (MAPK) , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and extracellular signal regulated kinase ( [ERK] ) 1/2 in A549 cells , and IL-8 and IL-6 secretion promoted by this fungus was *dependent* on activation of p38 and ERK 1/2 . Positive_regulation EPHB2 MAPK13 23207235 2705344 In addition , the phosphorylation levels of [ERK] and JNK were *induced* in macrophages at 15 min after LPS stimulation , while the phosphorylation level of p38 was induced at 1 h ; Positive_regulation EPHB2 MAPK13 23772367 2714508 VN attenuated radiation induced expression of p21 , an inhibitor of cell cycle progression , and selectively inhibited [Erk-] and p38 *dependent* p21 induction after radiation exposure through regulation of the activity of GSK-3ß . Positive_regulation EPHB2 MAPK13 23892041 2830323 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three inhibitors ( [ERK] inhibitor PD98059 , JNK inhibitor SP600125 and p38 *inhibitor* SB203580 ) . Positive_regulation EPHB2 MAPK13 23914844 2840559 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of [ERK] , JNK , NF-?B . Positive_regulation EPHB2 MAPK13 24225419 2897483 Therefore , by using the inhibitors SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific [ERK] *inhibitor* ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation EPHB2 MAPK13 24297112 2894202 Following treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation EPHB2 MAPK14 10207619 606846 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by and MEKs , in turn , are regulated by MAPK kinase kinases (MAPKKKs) . Positive_regulation EPHB2 MAPK14 10501195 648314 Inhibition of p38 MAPK had no significant effect on opioid induced ERK activation , indicating that p38 activity was not *required* for [ERK] activation , though its stimulation preceded ERK activation . Positive_regulation EPHB2 MAPK14 10872747 707014 Pre-treatment of the cells with PD98059 , a selective [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation EPHB2 MAPK14 11360180 816762 These data are consistent with a model where thrombin *induces* [ERK] activation via both PKC dependent and independent pathways , whereas p38 activation requires only PTKs . Positive_regulation EPHB2 MAPK14 11409852 826378 kinase inhibitors PD098059 and U0126 *prevent* [ERK] ( 1/2 ) phosphorylation by Tat . Positive_regulation EPHB2 MAPK14 11546664 856580 The kinase ( MEK ) inhibitors , PD-98059 and U-0126 , *blocked* IL-1 alpha induced [ERK] activation and partially attenuated cPLA(2)alpha phosphorylation and PGI ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation EPHB2 MAPK14 12386816 999752 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 and a biphasic *activation* of [ERK] . Positive_regulation EPHB2 MAPK14 12403788 1036164 SB203580 , a p38 inhibitor , and PD98059 , an [ERK] *inhibitor* , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation EPHB2 MAPK14 12450322 1018705 In summary , in H295R cells , ANG II activated [ERK] and p38 MAPKs , ANG II-induced p38 MAPK was mediated by 12-LO activation , and ANG II-induced aldosterone synthesis was *prevented* by 12-LO- and p38 inhibitors . Positive_regulation EPHB2 MAPK14 12460732 1021925 The kinase inhibitor PD 98059 *blocked* palytoxin stimulated [ERK] activation . Positive_regulation EPHB2 MAPK14 12511425 1070726 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation EPHB2 MAPK14 12527329 1048268 The inhibitor U0126 ( 10 microM ) , while *preventing* [ERK] phosphorylation in MDA-MB-468 cells , did not induce apoptosis . Positive_regulation EPHB2 MAPK14 12753285 1089630 Inhibition of PKA by H89 strikingly decreased cAMP stimulated phosphorylation of [ERK] and B-Raf , and inhibition by PD98059 *blocked* the effect of the nucleotide to activate ERK . Positive_regulation EPHB2 MAPK14 12946695 1136846 [ERK] *activation* by the leading to cyclic-AMP response element binding protein ( CREB ) phosphorylation is implicated in the formation of long-term memory . Positive_regulation EPHB2 MAPK14 14514663 1185737 Furthermore , two specific inhibitors ( SP600125 for JNK and UO126 for ERK ) could specifically *block* the activation of JNK and [ERK] and cell transformation . Positive_regulation EPHB2 MAPK14 14647418 1210375 These events were accompanied by the caspase independent downregulation of Raf-1 , inactivation of MEK1/2 , [ERK] , Akt , p70S6K , dephosphorylation of GSK-3 , and *activation* of c-Jun-N-terminal kinase (JNK) and p38 . Positive_regulation EPHB2 MAPK14 14648542 1188339 LPA- and S1P induced [ERK] phosphorylation was *dependent* on the activation of , phospholipase C (PLC) , and protein kinase C ( PKC ) , but was insensitive to pertussis toxin (PTX) . Positive_regulation EPHB2 MAPK14 14973553 1212494 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 MAPK14 14998726 1216718 Furthermore , we found that PD98059 , an [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation EPHB2 MAPK14 15102758 1239911 The inhibition of ERK by the specific inhibitor PD 98059 significantly *reduced* [phospho-ERK44/42] MAPK levels induced by C. albicans supernatant fluids in the IFN-gamma-plus-LPS-driven monocytes . Positive_regulation EPHB2 MAPK14 15147892 1248185 These findings strongly suggest that HHE induces NF-kappaB activation through IKK/NIK pathway and/or p38 and [ERK] *activation* associated with oxidative stress in endothelial cells . Positive_regulation EPHB2 MAPK14 15271999 1296260 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation EPHB2 MAPK14 15659876 1350291 The anabolic effect of TNF-alpha was *mediated* at least in part by , especially by an [extracellular regulated kinases (ERK)] . Positive_regulation EPHB2 MAPK14 16464862 1548077 c-Fos hyperphosphorylation at threonine 325 was found to parallel this p38 *mediated* modulation of [ERK] activation . Positive_regulation EPHB2 MAPK14 16920714 1626739 Overall , our results suggest that intracellular HIV-Tat induces IL-10 transcription by [ERK] dependent CREB-1 transcription factor *activation* through Ser ( 133 ) phosphorylation . Positive_regulation EPHB2 MAPK14 17255201 1725205 Prolactin *induced* phosphorylation of JAK2 and [ERK] , whereas IFN-gamma induced phosphorylation of JAK1 , JAK2 , and p38 . Positive_regulation EPHB2 MAPK14 17255949 1696654 *promotes* stimulus independent [ERK] nuclear translocation . Positive_regulation EPHB2 MAPK14 18164124 1869599 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 , but not by the *activation* of JNK , [ERK] , and NF-kappaB pathway . Positive_regulation EPHB2 MAPK14 18285354 1885395 Pre-treatment with the inhibitors SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( [ERK] *inhibitor* ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation EPHB2 MAPK14 18401006 1925762 CyaA enhanced LPS induced phosphorylation of p38 MAPK and [ERK] in DC , and inhibitors of p38 , MEK , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation EPHB2 MAPK14 18413315 1920481 Furthermore , a inhibitor , PD98059 , *blocked* the eena induced cell proliferation and activation of [ERK] signaling . Positive_regulation EPHB2 MAPK14 18520049 1918662 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of [ERK] , rather than by the *activation* of p38 , in the spinal cord . Positive_regulation EPHB2 MAPK14 19022376 2016964 A inhibitor *reduced* [ERK] phosphorylation in cells with reduced expression of A-type lamins and emerin . Positive_regulation EPHB2 MAPK14 19276187 2051407 Treatment of cells with sphingosine induced suppression of [ERK] and *activation* of p38 . Positive_regulation EPHB2 MAPK14 19429670 2106907 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either [ERK] *inhibitor* , inhibitor or NF-kappaB inhibitor . Positive_regulation EPHB2 MAPK14 19433984 2096493 S1P stimulation of [ERK] was completely *inhibited* by an S1P1/3 subtype receptor antagonist ( VPC23019 ) , by a Gi protein inhibitor ( pertussis toxin ) and by a kinase inhibitor ( PD98059 ) . Positive_regulation EPHB2 MAPK14 19522739 2103130 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation EPHB2 MAPK14 19803745 2232100 Butyrate treatment increased the phosphorylation of [ERK] , not p38 MAPK and JNK , but inhibition of ERK and p38 phosphorylation did not *inhibit* butyrate reduced cell viability . Positive_regulation EPHB2 MAPK14 19879308 2196979 The administration of curcumin led to increased levels of [phosphor-ERK] and AKT , which were each *blocked* by and PI-3K inhibitors . Positive_regulation EPHB2 MAPK14 20025124 2175502 Prior treatment of the cells with PD98059 , an [ERK] kinase *inhibitor* or SB203580 , a inhibitor , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation EPHB2 MAPK14 20463356 2301061 TNF induced proMMP9 production , as measured by zymography , was significantly blocked/inhibited by TNF receptor 1 ( TNFRSF1A ) antibody , NFKB activation inhibitor (NFKBAI) , and MAPK1/3 ( [ERK] ) *inhibitor* ( U0126 ) ( P < 0.01 ) , but not by TNF receptor 2 ( TNFRSF1B ) antibody , ( p38 MAPK ) inhibitor ( SB203580 ) , and MAPK8/9/10 ( JNK ) inhibitor ( SP600125 ) . Positive_regulation EPHB2 MAPK14 21126656 2355788 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by [ERK] . Positive_regulation EPHB2 MAPK14 21311676 2360023 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation EPHB2 MAPK14 21488184 2417962 Dexmedetomidine induced phosphorylation of JNK and p38 in rat aortic SMCs , but did not *induce* phosphorylation of [ERK] . Positive_regulation EPHB2 MAPK14 21558315 2445092 The blockade of cAMP *induced* [kinase/ERK] activation abated MKP-1 phosphorylation but only partially reduced flag-MKP-1 protein accumulation . Positive_regulation EPHB2 MAPK14 21720001 2451705 kinase inhibitor , PD98059 ( 10 ( -6 ) M ) , completely *inhibited* the PDGF induced increase in [ERK] activity . Positive_regulation EPHB2 MAPK14 22687715 2669871 Moreover , P. brasiliensis yeasts induced activation of p38 mitogen activated protein kinase (MAPK) , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and extracellular signal regulated kinase ( [ERK] ) 1/2 in A549 cells , and IL-8 and IL-6 secretion promoted by this fungus was *dependent* on activation of p38 and ERK 1/2 . Positive_regulation EPHB2 MAPK14 23207235 2705345 In addition , the phosphorylation levels of [ERK] and JNK were *induced* in macrophages at 15 min after LPS stimulation , while the phosphorylation level of p38 was induced at 1 h ; Positive_regulation EPHB2 MAPK14 23772367 2714509 VN attenuated radiation induced expression of p21 , an inhibitor of cell cycle progression , and selectively inhibited [Erk-] and p38 dependent p21 *induction* after radiation exposure through regulation of the activity of GSK-3ß . Positive_regulation EPHB2 MAPK14 23892041 2830324 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three inhibitors ( [ERK] inhibitor PD98059 , JNK inhibitor SP600125 and p38 *inhibitor* SB203580 ) . Positive_regulation EPHB2 MAPK14 23914844 2840560 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of [ERK] , JNK , NF-?B . Positive_regulation EPHB2 MAPK14 24225419 2897484 Therefore , by using the inhibitors SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific [ERK] *inhibitor* ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation EPHB2 MAPK14 24297112 2894203 Following treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation EPHB2 MAPK15 10207619 606840 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by and MEKs , in turn , are regulated by MAPK kinase kinases (MAPKKKs) . Positive_regulation EPHB2 MAPK15 10501195 648308 Inhibition of p38 MAPK had no significant effect on opioid induced ERK activation , indicating that p38 activity was not *required* for [ERK] activation , though its stimulation preceded ERK activation . Positive_regulation EPHB2 MAPK15 10872747 707008 Pre-treatment of the cells with PD98059 , a selective [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation EPHB2 MAPK15 11360180 816755 These data are consistent with a model where thrombin *induces* [ERK] activation via both PKC dependent and independent pathways , whereas p38 activation requires only PTKs . Positive_regulation EPHB2 MAPK15 11409852 826372 kinase inhibitors PD098059 and U0126 *prevent* [ERK] ( 1/2 ) phosphorylation by Tat . Positive_regulation EPHB2 MAPK15 11546664 856566 The kinase ( MEK ) inhibitors , PD-98059 and U-0126 , *blocked* IL-1 alpha induced [ERK] activation and partially attenuated cPLA(2)alpha phosphorylation and PGI ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation EPHB2 MAPK15 12386816 999746 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 and a biphasic *activation* of [ERK] . Positive_regulation EPHB2 MAPK15 12403788 1036158 SB203580 , a p38 inhibitor , and PD98059 , an [ERK] *inhibitor* , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation EPHB2 MAPK15 12450322 1018698 In summary , in H295R cells , ANG II activated [ERK] and p38 MAPKs , ANG II-induced p38 MAPK was mediated by 12-LO activation , and ANG II-induced aldosterone synthesis was *prevented* by 12-LO- and p38 inhibitors . Positive_regulation EPHB2 MAPK15 12460732 1021919 The kinase inhibitor PD 98059 *blocked* palytoxin stimulated [ERK] activation . Positive_regulation EPHB2 MAPK15 12511425 1070720 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation EPHB2 MAPK15 12527329 1048262 The inhibitor U0126 ( 10 microM ) , while *preventing* [ERK] phosphorylation in MDA-MB-468 cells , did not induce apoptosis . Positive_regulation EPHB2 MAPK15 12753285 1089624 Inhibition of PKA by H89 strikingly decreased cAMP stimulated phosphorylation of [ERK] and B-Raf , and inhibition by PD98059 *blocked* the effect of the nucleotide to activate ERK . Positive_regulation EPHB2 MAPK15 12946695 1136840 [ERK] *activation* by the leading to cyclic-AMP response element binding protein ( CREB ) phosphorylation is implicated in the formation of long-term memory . Positive_regulation EPHB2 MAPK15 14514663 1185731 Furthermore , two specific inhibitors ( SP600125 for JNK and UO126 for ERK ) could specifically *block* the activation of JNK and [ERK] and cell transformation . Positive_regulation EPHB2 MAPK15 14647418 1210368 These events were accompanied by the caspase independent downregulation of Raf-1 , inactivation of MEK1/2 , [ERK] , Akt , p70S6K , dephosphorylation of GSK-3 , and *activation* of c-Jun-N-terminal kinase (JNK) and p38 . Positive_regulation EPHB2 MAPK15 14648542 1188332 LPA- and S1P induced [ERK] phosphorylation was *dependent* on the activation of , phospholipase C (PLC) , and protein kinase C ( PKC ) , but was insensitive to pertussis toxin (PTX) . Positive_regulation EPHB2 MAPK15 14973553 1212462 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 MAPK15 14998726 1216711 Furthermore , we found that PD98059 , an [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation EPHB2 MAPK15 15102758 1239905 The inhibition of ERK by the specific inhibitor PD 98059 significantly *reduced* [phospho-ERK44/42] MAPK levels induced by C. albicans supernatant fluids in the IFN-gamma-plus-LPS-driven monocytes . Positive_regulation EPHB2 MAPK15 15147892 1248179 These findings strongly suggest that HHE induces NF-kappaB activation through IKK/NIK pathway and/or p38 and [ERK] *activation* associated with oxidative stress in endothelial cells . Positive_regulation EPHB2 MAPK15 15271999 1296254 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation EPHB2 MAPK15 15659876 1350285 The anabolic effect of TNF-alpha was *mediated* at least in part by , especially by an [extracellular regulated kinases (ERK)] . Positive_regulation EPHB2 MAPK15 16464862 1548071 c-Fos hyperphosphorylation at threonine 325 was found to parallel this p38 *mediated* modulation of [ERK] activation . Positive_regulation EPHB2 MAPK15 16920714 1626733 Overall , our results suggest that intracellular HIV-Tat induces IL-10 transcription by [ERK] dependent CREB-1 transcription factor *activation* through Ser ( 133 ) phosphorylation . Positive_regulation EPHB2 MAPK15 17255201 1725196 Prolactin *induced* phosphorylation of JAK2 and [ERK] , whereas IFN-gamma induced phosphorylation of JAK1 , JAK2 , and p38 . Positive_regulation EPHB2 MAPK15 18164124 1869593 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 , but not by the *activation* of JNK , [ERK] , and NF-kappaB pathway . Positive_regulation EPHB2 MAPK15 18285354 1885389 Pre-treatment with the inhibitors SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( [ERK] *inhibitor* ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation EPHB2 MAPK15 18401006 1925749 CyaA enhanced LPS induced phosphorylation of p38 MAPK and [ERK] in DC , and inhibitors of p38 , MEK , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation EPHB2 MAPK15 18413315 1920475 Furthermore , a inhibitor , PD98059 , *blocked* the eena induced cell proliferation and activation of [ERK] signaling . Positive_regulation EPHB2 MAPK15 18520049 1918656 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of [ERK] , rather than by the *activation* of p38 , in the spinal cord . Positive_regulation EPHB2 MAPK15 19022376 2016958 A inhibitor *reduced* [ERK] phosphorylation in cells with reduced expression of A-type lamins and emerin . Positive_regulation EPHB2 MAPK15 19276187 2051401 Treatment of cells with sphingosine induced suppression of [ERK] and *activation* of p38 . Positive_regulation EPHB2 MAPK15 19429670 2106900 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either [ERK] *inhibitor* , inhibitor or NF-kappaB inhibitor . Positive_regulation EPHB2 MAPK15 19433984 2096487 S1P stimulation of [ERK] was completely *inhibited* by an S1P1/3 subtype receptor antagonist ( VPC23019 ) , by a Gi protein inhibitor ( pertussis toxin ) and by a kinase inhibitor ( PD98059 ) . Positive_regulation EPHB2 MAPK15 19522739 2103124 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation EPHB2 MAPK15 19803745 2232094 Butyrate treatment increased the phosphorylation of [ERK] , not p38 MAPK and JNK , but inhibition of ERK and p38 phosphorylation did not *inhibit* butyrate reduced cell viability . Positive_regulation EPHB2 MAPK15 19879308 2196973 The administration of curcumin led to increased levels of [phosphor-ERK] and AKT , which were each *blocked* by and PI-3K inhibitors . Positive_regulation EPHB2 MAPK15 20025124 2175496 Prior treatment of the cells with PD98059 , an [ERK] kinase *inhibitor* or SB203580 , a inhibitor , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation EPHB2 MAPK15 21126656 2355782 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by [ERK] . Positive_regulation EPHB2 MAPK15 21311676 2360017 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation EPHB2 MAPK15 21488184 2417956 Dexmedetomidine induced phosphorylation of JNK and p38 in rat aortic SMCs , but did not *induce* phosphorylation of [ERK] . Positive_regulation EPHB2 MAPK15 21558315 2445086 The blockade of cAMP *induced* [kinase/ERK] activation abated MKP-1 phosphorylation but only partially reduced flag-MKP-1 protein accumulation . Positive_regulation EPHB2 MAPK15 21720001 2451699 kinase inhibitor , PD98059 ( 10 ( -6 ) M ) , completely *inhibited* the PDGF induced increase in [ERK] activity . Positive_regulation EPHB2 MAPK15 22687715 2669865 Moreover , P. brasiliensis yeasts induced activation of p38 mitogen activated protein kinase (MAPK) , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and extracellular signal regulated kinase ( [ERK] ) 1/2 in A549 cells , and IL-8 and IL-6 secretion promoted by this fungus was *dependent* on activation of p38 and ERK 1/2 . Positive_regulation EPHB2 MAPK15 23207235 2705339 In addition , the phosphorylation levels of [ERK] and JNK were *induced* in macrophages at 15 min after LPS stimulation , while the phosphorylation level of p38 was induced at 1 h ; Positive_regulation EPHB2 MAPK15 23772367 2714503 VN attenuated radiation induced expression of p21 , an inhibitor of cell cycle progression , and selectively inhibited [Erk-] and p38 dependent p21 *induction* after radiation exposure through regulation of the activity of GSK-3ß . Positive_regulation EPHB2 MAPK15 23892041 2830318 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three inhibitors ( [ERK] inhibitor PD98059 , JNK inhibitor SP600125 and p38 *inhibitor* SB203580 ) . Positive_regulation EPHB2 MAPK15 23914844 2840554 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of [ERK] , JNK , NF-?B . Positive_regulation EPHB2 MAPK15 24225419 2897478 Therefore , by using the inhibitors SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific [ERK] *inhibitor* ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation EPHB2 MAPK15 24297112 2894197 Following treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation EPHB2 MAPK3 10207619 606847 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by and MEKs , in turn , are regulated by MAPK kinase kinases (MAPKKKs) . Positive_regulation EPHB2 MAPK3 10501195 648315 Inhibition of p38 MAPK had no significant effect on opioid induced ERK activation , indicating that p38 activity was not *required* for [ERK] activation , though its stimulation preceded ERK activation . Positive_regulation EPHB2 MAPK3 10872747 707015 Pre-treatment of the cells with PD98059 , a selective [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation EPHB2 MAPK3 11360180 816763 These data are consistent with a model where thrombin *induces* [ERK] activation via both PKC dependent and independent pathways , whereas p38 activation requires only PTKs . Positive_regulation EPHB2 MAPK3 11409852 826379 kinase inhibitors PD098059 and U0126 *prevent* [ERK] ( 1/2 ) phosphorylation by Tat . Positive_regulation EPHB2 MAPK3 11517300 851411 We conclude that glucagon induced MEK1/2 and activation is mediated by PKA and that an increase in intracellular calcium concentration is *required* for maximal [ERK] activation . Positive_regulation EPHB2 MAPK3 11546664 856581 The kinase ( MEK ) inhibitors , PD-98059 and U-0126 , *blocked* IL-1 alpha induced [ERK] activation and partially attenuated cPLA(2)alpha phosphorylation and PGI ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation EPHB2 MAPK3 12386816 999753 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 and a biphasic *activation* of [ERK] . Positive_regulation EPHB2 MAPK3 12403788 1036165 SB203580 , a p38 inhibitor , and PD98059 , an [ERK] *inhibitor* , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation EPHB2 MAPK3 12450322 1018706 In summary , in H295R cells , ANG II activated [ERK] and p38 MAPKs , ANG II-induced p38 MAPK was mediated by 12-LO activation , and ANG II-induced aldosterone synthesis was *prevented* by 12-LO- and p38 inhibitors . Positive_regulation EPHB2 MAPK3 12460732 1021926 The kinase inhibitor PD 98059 *blocked* palytoxin stimulated [ERK] activation . Positive_regulation EPHB2 MAPK3 12511425 1070727 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation EPHB2 MAPK3 12527329 1048269 The inhibitor U0126 ( 10 microM ) , while *preventing* [ERK] phosphorylation in MDA-MB-468 cells , did not induce apoptosis . Positive_regulation EPHB2 MAPK3 12753285 1089631 Inhibition of PKA by H89 strikingly decreased cAMP stimulated phosphorylation of [ERK] and B-Raf , and inhibition by PD98059 *blocked* the effect of the nucleotide to activate ERK . Positive_regulation EPHB2 MAPK3 12946695 1136847 [ERK] *activation* by the leading to cyclic-AMP response element binding protein ( CREB ) phosphorylation is implicated in the formation of long-term memory . Positive_regulation EPHB2 MAPK3 14514663 1185738 Furthermore , two specific inhibitors ( SP600125 for JNK and UO126 for ERK ) could specifically *block* the activation of JNK and [ERK] and cell transformation . Positive_regulation EPHB2 MAPK3 14647418 1210376 These events were accompanied by the caspase independent downregulation of Raf-1 , inactivation of MEK1/2 , [ERK] , Akt , p70S6K , dephosphorylation of GSK-3 , and *activation* of c-Jun-N-terminal kinase (JNK) and p38 . Positive_regulation EPHB2 MAPK3 14648542 1188340 LPA- and S1P induced [ERK] phosphorylation was *dependent* on the activation of , phospholipase C (PLC) , and protein kinase C ( PKC ) , but was insensitive to pertussis toxin (PTX) . Positive_regulation EPHB2 MAPK3 14973553 1212495 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 MAPK3 14988413 1236707 We conclude that glucagon induced activation is mediated by PKA and that an increase in [ Ca ( 2+ ) ] ( i ) is *required* for maximal [ERK] activation . Positive_regulation EPHB2 MAPK3 14998726 1216719 Furthermore , we found that PD98059 , an [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation EPHB2 MAPK3 15102758 1239912 The inhibition of ERK by the specific inhibitor PD 98059 significantly *reduced* [phospho-ERK44/42] MAPK levels induced by C. albicans supernatant fluids in the IFN-gamma-plus-LPS-driven monocytes . Positive_regulation EPHB2 MAPK3 15147892 1248186 These findings strongly suggest that HHE induces NF-kappaB activation through IKK/NIK pathway and/or p38 and [ERK] *activation* associated with oxidative stress in endothelial cells . Positive_regulation EPHB2 MAPK3 15271999 1296261 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation EPHB2 MAPK3 15659876 1350292 The anabolic effect of TNF-alpha was *mediated* at least in part by , especially by an [extracellular regulated kinases (ERK)] . Positive_regulation EPHB2 MAPK3 16464862 1548078 c-Fos hyperphosphorylation at threonine 325 was found to parallel this p38 *mediated* modulation of [ERK] activation . Positive_regulation EPHB2 MAPK3 16920714 1626740 Overall , our results suggest that intracellular HIV-Tat induces IL-10 transcription by [ERK] *dependent* CREB-1 transcription factor activation through Ser ( 133 ) phosphorylation . Positive_regulation EPHB2 MAPK3 17127048 1732238 In conclusion , ( 1 ) p38MAPK-pathway rather than ERK-pathway may play a more basic role in the regulation of the increased T-bet expression in asthma , and ( 2 ) [ERK-] and p38MAPK-activation modulate IFNgamma expression independently of T-bet and this regulatory role of on IFNgamma release is *impaired* in asthma . Positive_regulation EPHB2 MAPK3 17255201 1725206 Prolactin *induced* phosphorylation of JAK2 and [ERK] , whereas IFN-gamma induced phosphorylation of JAK1 , JAK2 , and p38 . Positive_regulation EPHB2 MAPK3 17700518 1865976 PEA-15 regulates the level of phosphorylated [extracellular regulated kinase (ERK)1/2] in glioblastoma cells and the PEA-15 dependent protection from glucose deprivation induced cell death *requires* signaling . Positive_regulation EPHB2 MAPK3 18164124 1869600 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 , but not by the *activation* of JNK , [ERK] , and NF-kappaB pathway . Positive_regulation EPHB2 MAPK3 18263604 1903581 Cysts in ADPKD exhibit both increased proliferation and activation of [MAPK/ERK] , but cyst growth is not *prevented* by inhibition of activation . Positive_regulation EPHB2 MAPK3 18285354 1885396 Pre-treatment with the inhibitors SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( [ERK] *inhibitor* ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation EPHB2 MAPK3 18401006 1925763 CyaA enhanced LPS induced phosphorylation of p38 MAPK and [ERK] in DC , and inhibitors of p38 , MEK , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation EPHB2 MAPK3 18413315 1920482 Furthermore , a inhibitor , PD98059 , *blocked* the eena induced cell proliferation and activation of [ERK] signaling . Positive_regulation EPHB2 MAPK3 18463290 1910048 Using 293A cells and in vitro experiments , we detail the formation of a ternary complex of [MEK/ERK/hBVR] , *activation* of MEK1 and kinase activities by hBVR , and phosphorylation of hBVR by ERK1/2 . Positive_regulation EPHB2 MAPK3 18520049 1918663 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of [ERK] , rather than by the *activation* of p38 , in the spinal cord . Positive_regulation EPHB2 MAPK3 19022376 2016965 A inhibitor *reduced* [ERK] phosphorylation in cells with reduced expression of A-type lamins and emerin . Positive_regulation EPHB2 MAPK3 19276187 2051408 Treatment of cells with sphingosine induced suppression of [ERK] and *activation* of p38 . Positive_regulation EPHB2 MAPK3 19429670 2106908 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either [ERK] *inhibitor* , inhibitor or NF-kappaB inhibitor . Positive_regulation EPHB2 MAPK3 19433984 2096494 S1P stimulation of [ERK] was completely *inhibited* by an S1P1/3 subtype receptor antagonist ( VPC23019 ) , by a Gi protein inhibitor ( pertussis toxin ) and by a kinase inhibitor ( PD98059 ) . Positive_regulation EPHB2 MAPK3 19522739 2103131 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation EPHB2 MAPK3 19562672 2136679 a maximum observed at 1-2 h followed by a decline to basal levels beyond 4 h. Acidic pH also activated ERK1/2 phosphorylation , whereas inhibitors PD98059 and U0216 *blocked* both acid induced Egr-1 and [ERK] translocation and expression . Positive_regulation EPHB2 MAPK3 19803745 2232101 Butyrate treatment increased the phosphorylation of [ERK] , not p38 MAPK and JNK , but inhibition of ERK and p38 phosphorylation did not *inhibit* butyrate reduced cell viability . Positive_regulation EPHB2 MAPK3 19836351 2165140 EGFR-mutant non-small cell lung cancer cell lines constitutively express active and *require* [ERK] activity for survival . Positive_regulation EPHB2 MAPK3 19879308 2196980 The administration of curcumin led to increased levels of [phosphor-ERK] and AKT , which were each *blocked* by and PI-3K inhibitors . Positive_regulation EPHB2 MAPK3 19906834 2203537 Both visfatin and nicotinamide mononucleotide *induced* activation of both insulin receptor and extracellular signal regulated kinase ( [ERK] ) 1/2 , with visfatin induced insulin activation being inhibited by FK866 . Positive_regulation EPHB2 MAPK3 20025124 2175503 Prior treatment of the cells with PD98059 , an [ERK] kinase *inhibitor* or SB203580 , a inhibitor , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation EPHB2 MAPK3 21126656 2355789 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by [ERK] . Positive_regulation EPHB2 MAPK3 21311676 2360024 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation EPHB2 MAPK3 21412767 2521373 EGF stimulated IL-8 production , phosphorylation of Akt and [Erk] , and cell proliferation and movement could be *inhibited* by EGFR inhibitor ( Erlotinib ) , PI3K inhibitor ( GDC-0941 BEZ-235 and SHBM1009 ) , and inhibitor ( PD98059 ) . Positive_regulation EPHB2 MAPK3 21488184 2417963 Dexmedetomidine induced phosphorylation of JNK and p38 in rat aortic SMCs , but did not *induce* phosphorylation of [ERK] . Positive_regulation EPHB2 MAPK3 21558315 2445093 The blockade of cAMP *induced* [kinase/ERK] activation abated MKP-1 phosphorylation but only partially reduced flag-MKP-1 protein accumulation . Positive_regulation EPHB2 MAPK3 21720001 2451706 kinase inhibitor , PD98059 ( 10 ( -6 ) M ) , completely *inhibited* the PDGF induced increase in [ERK] activity . Positive_regulation EPHB2 MAPK3 22687715 2669872 Moreover , P. brasiliensis yeasts induced activation of p38 mitogen activated protein kinase (MAPK) , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and extracellular signal regulated kinase ( [ERK] ) 1/2 in A549 cells , and IL-8 and IL-6 secretion promoted by this fungus was *dependent* on activation of p38 and ERK 1/2 . Positive_regulation EPHB2 MAPK3 22843704 2687366 Activation of G ( s ) by ß-adrenergic receptors leads to ( i ) canonical Erk1/2 activation via AC , and ( ii ) release of Gß? , which then associates with activated and *induces* [Erk] ( Thr188 ) phosphorylation , causing nuclear accumulation of Erk and ultimately cardiomyocyte hypertrophy . Positive_regulation EPHB2 MAPK3 23207235 2705346 In addition , the phosphorylation levels of [ERK] and JNK were *induced* in macrophages at 15 min after LPS stimulation , while the phosphorylation level of p38 was induced at 1 h ; Positive_regulation EPHB2 MAPK3 23772367 2714510 VN attenuated radiation induced expression of p21 , an inhibitor of cell cycle progression , and selectively inhibited [Erk-] and p38 *dependent* p21 induction after radiation exposure through regulation of the activity of GSK-3ß . Positive_regulation EPHB2 MAPK3 23892041 2830325 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three inhibitors ( [ERK] inhibitor PD98059 , JNK inhibitor SP600125 and p38 *inhibitor* SB203580 ) . Positive_regulation EPHB2 MAPK3 23914844 2840561 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of [ERK] , JNK , NF-?B . Positive_regulation EPHB2 MAPK3 24033945 2842306 CIH procedure exerted complex effects on [ERK] expressions ( total decreased whereas the ratio of phosphorylated to total ERK1/2 *increased* ) . Positive_regulation EPHB2 MAPK3 24225419 2897485 Therefore , by using the inhibitors SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific [ERK] *inhibitor* ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation EPHB2 MAPK3 24297112 2894204 Following treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation EPHB2 MAPK4 10207619 606848 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by and MEKs , in turn , are regulated by MAPK kinase kinases (MAPKKKs) . Positive_regulation EPHB2 MAPK4 10501195 648316 Inhibition of p38 MAPK had no significant effect on opioid induced ERK activation , indicating that p38 activity was not *required* for [ERK] activation , though its stimulation preceded ERK activation . Positive_regulation EPHB2 MAPK4 10872747 707016 Pre-treatment of the cells with PD98059 , a selective [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation EPHB2 MAPK4 11360180 816764 These data are consistent with a model where thrombin *induces* [ERK] activation via both PKC dependent and independent pathways , whereas p38 activation requires only PTKs . Positive_regulation EPHB2 MAPK4 11409852 826380 kinase inhibitors PD098059 and U0126 *prevent* [ERK] ( 1/2 ) phosphorylation by Tat . Positive_regulation EPHB2 MAPK4 11546664 856582 The kinase ( MEK ) inhibitors , PD-98059 and U-0126 , *blocked* IL-1 alpha induced [ERK] activation and partially attenuated cPLA(2)alpha phosphorylation and PGI ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation EPHB2 MAPK4 12386816 999754 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 and a biphasic *activation* of [ERK] . Positive_regulation EPHB2 MAPK4 12403788 1036166 SB203580 , a p38 inhibitor , and PD98059 , an [ERK] *inhibitor* , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation EPHB2 MAPK4 12450322 1018707 In summary , in H295R cells , ANG II activated [ERK] and p38 MAPKs , ANG II-induced p38 MAPK was mediated by 12-LO activation , and ANG II-induced aldosterone synthesis was *prevented* by 12-LO- and p38 inhibitors . Positive_regulation EPHB2 MAPK4 12460732 1021927 The kinase inhibitor PD 98059 *blocked* palytoxin stimulated [ERK] activation . Positive_regulation EPHB2 MAPK4 12511425 1070728 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation EPHB2 MAPK4 12527329 1048270 The inhibitor U0126 ( 10 microM ) , while *preventing* [ERK] phosphorylation in MDA-MB-468 cells , did not induce apoptosis . Positive_regulation EPHB2 MAPK4 12753285 1089632 Inhibition of PKA by H89 strikingly decreased cAMP stimulated phosphorylation of [ERK] and B-Raf , and inhibition by PD98059 *blocked* the effect of the nucleotide to activate ERK . Positive_regulation EPHB2 MAPK4 12946695 1136848 [ERK] *activation* by the leading to cyclic-AMP response element binding protein ( CREB ) phosphorylation is implicated in the formation of long-term memory . Positive_regulation EPHB2 MAPK4 14514663 1185739 Furthermore , two specific inhibitors ( SP600125 for JNK and UO126 for ERK ) could specifically *block* the activation of JNK and [ERK] and cell transformation . Positive_regulation EPHB2 MAPK4 14647418 1210377 These events were accompanied by the caspase independent downregulation of Raf-1 , inactivation of MEK1/2 , [ERK] , Akt , p70S6K , dephosphorylation of GSK-3 , and *activation* of c-Jun-N-terminal kinase (JNK) and p38 . Positive_regulation EPHB2 MAPK4 14648542 1188341 LPA- and S1P induced [ERK] phosphorylation was *dependent* on the activation of , phospholipase C (PLC) , and protein kinase C ( PKC ) , but was insensitive to pertussis toxin (PTX) . Positive_regulation EPHB2 MAPK4 14973553 1212496 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 MAPK4 14998726 1216720 Furthermore , we found that PD98059 , an [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation EPHB2 MAPK4 15102758 1239913 The inhibition of ERK by the specific inhibitor PD 98059 significantly *reduced* [phospho-ERK44/42] MAPK levels induced by C. albicans supernatant fluids in the IFN-gamma-plus-LPS-driven monocytes . Positive_regulation EPHB2 MAPK4 15147892 1248187 These findings strongly suggest that HHE induces NF-kappaB activation through IKK/NIK pathway and/or p38 and [ERK] *activation* associated with oxidative stress in endothelial cells . Positive_regulation EPHB2 MAPK4 15271999 1296262 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation EPHB2 MAPK4 15659876 1350293 The anabolic effect of TNF-alpha was *mediated* at least in part by , especially by an [extracellular regulated kinases (ERK)] . Positive_regulation EPHB2 MAPK4 16464862 1548079 c-Fos hyperphosphorylation at threonine 325 was found to parallel this p38 *mediated* modulation of [ERK] activation . Positive_regulation EPHB2 MAPK4 16920714 1626741 Overall , our results suggest that intracellular HIV-Tat induces IL-10 transcription by [ERK] dependent CREB-1 transcription factor *activation* through Ser ( 133 ) phosphorylation . Positive_regulation EPHB2 MAPK4 17255201 1725207 Prolactin *induced* phosphorylation of JAK2 and [ERK] , whereas IFN-gamma induced phosphorylation of JAK1 , JAK2 , and p38 . Positive_regulation EPHB2 MAPK4 18164124 1869601 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 , but not by the *activation* of JNK , [ERK] , and NF-kappaB pathway . Positive_regulation EPHB2 MAPK4 18285354 1885397 Pre-treatment with the inhibitors SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( [ERK] *inhibitor* ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation EPHB2 MAPK4 18401006 1925764 CyaA enhanced LPS induced phosphorylation of p38 MAPK and [ERK] in DC , and inhibitors of p38 , MEK , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation EPHB2 MAPK4 18413315 1920483 Furthermore , a inhibitor , PD98059 , *blocked* the eena induced cell proliferation and activation of [ERK] signaling . Positive_regulation EPHB2 MAPK4 18520049 1918664 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of [ERK] , rather than by the *activation* of p38 , in the spinal cord . Positive_regulation EPHB2 MAPK4 19022376 2016966 A inhibitor *reduced* [ERK] phosphorylation in cells with reduced expression of A-type lamins and emerin . Positive_regulation EPHB2 MAPK4 19276187 2051409 Treatment of cells with sphingosine induced suppression of [ERK] and *activation* of p38 . Positive_regulation EPHB2 MAPK4 19429670 2106909 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either [ERK] *inhibitor* , inhibitor or NF-kappaB inhibitor . Positive_regulation EPHB2 MAPK4 19433984 2096495 S1P stimulation of [ERK] was completely *inhibited* by an S1P1/3 subtype receptor antagonist ( VPC23019 ) , by a Gi protein inhibitor ( pertussis toxin ) and by a kinase inhibitor ( PD98059 ) . Positive_regulation EPHB2 MAPK4 19522739 2103132 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation EPHB2 MAPK4 19803745 2232102 Butyrate treatment increased the phosphorylation of [ERK] , not p38 MAPK and JNK , but inhibition of ERK and p38 phosphorylation did not *inhibit* butyrate reduced cell viability . Positive_regulation EPHB2 MAPK4 19879308 2196981 The administration of curcumin led to increased levels of [phosphor-ERK] and AKT , which were each *blocked* by and PI-3K inhibitors . Positive_regulation EPHB2 MAPK4 20025124 2175504 Prior treatment of the cells with PD98059 , an [ERK] kinase *inhibitor* or SB203580 , a inhibitor , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation EPHB2 MAPK4 21126656 2355790 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by [ERK] . Positive_regulation EPHB2 MAPK4 21311676 2360025 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation EPHB2 MAPK4 21488184 2417964 Dexmedetomidine induced phosphorylation of JNK and p38 in rat aortic SMCs , but did not *induce* phosphorylation of [ERK] . Positive_regulation EPHB2 MAPK4 21558315 2445094 The blockade of cAMP *induced* [kinase/ERK] activation abated MKP-1 phosphorylation but only partially reduced flag-MKP-1 protein accumulation . Positive_regulation EPHB2 MAPK4 21720001 2451707 kinase inhibitor , PD98059 ( 10 ( -6 ) M ) , completely *inhibited* the PDGF induced increase in [ERK] activity . Positive_regulation EPHB2 MAPK4 22687715 2669873 Moreover , P. brasiliensis yeasts induced activation of p38 mitogen activated protein kinase (MAPK) , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and extracellular signal regulated kinase ( [ERK] ) 1/2 in A549 cells , and IL-8 and IL-6 secretion promoted by this fungus was *dependent* on activation of p38 and ERK 1/2 . Positive_regulation EPHB2 MAPK4 23207235 2705347 In addition , the phosphorylation levels of [ERK] and JNK were *induced* in macrophages at 15 min after LPS stimulation , while the phosphorylation level of p38 was induced at 1 h ; Positive_regulation EPHB2 MAPK4 23772367 2714511 VN attenuated radiation induced expression of p21 , an inhibitor of cell cycle progression , and selectively inhibited [Erk-] and p38 dependent p21 *induction* after radiation exposure through regulation of the activity of GSK-3ß . Positive_regulation EPHB2 MAPK4 23892041 2830326 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three inhibitors ( [ERK] inhibitor PD98059 , JNK inhibitor SP600125 and p38 *inhibitor* SB203580 ) . Positive_regulation EPHB2 MAPK4 23914844 2840562 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of [ERK] , JNK , NF-?B . Positive_regulation EPHB2 MAPK4 24225419 2897486 Therefore , by using the inhibitors SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific [ERK] *inhibitor* ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation EPHB2 MAPK4 24297112 2894205 Following treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation EPHB2 MAPK6 10207619 606849 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by and MEKs , in turn , are regulated by MAPK kinase kinases (MAPKKKs) . Positive_regulation EPHB2 MAPK6 10501195 648317 Inhibition of p38 MAPK had no significant effect on opioid induced ERK activation , indicating that p38 activity was not *required* for [ERK] activation , though its stimulation preceded ERK activation . Positive_regulation EPHB2 MAPK6 10872747 707017 Pre-treatment of the cells with PD98059 , a selective [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation EPHB2 MAPK6 11360180 816765 These data are consistent with a model where thrombin *induces* [ERK] activation via both PKC dependent and independent pathways , whereas p38 activation requires only PTKs . Positive_regulation EPHB2 MAPK6 11409852 826381 kinase inhibitors PD098059 and U0126 *prevent* [ERK] ( 1/2 ) phosphorylation by Tat . Positive_regulation EPHB2 MAPK6 11546664 856583 The kinase ( MEK ) inhibitors , PD-98059 and U-0126 , *blocked* IL-1 alpha induced [ERK] activation and partially attenuated cPLA(2)alpha phosphorylation and PGI ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation EPHB2 MAPK6 12386816 999755 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 and a biphasic *activation* of [ERK] . Positive_regulation EPHB2 MAPK6 12403788 1036167 SB203580 , a p38 inhibitor , and PD98059 , an [ERK] *inhibitor* , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation EPHB2 MAPK6 12450322 1018708 In summary , in H295R cells , ANG II activated [ERK] and p38 MAPKs , ANG II-induced p38 MAPK was mediated by 12-LO activation , and ANG II-induced aldosterone synthesis was *prevented* by 12-LO- and p38 inhibitors . Positive_regulation EPHB2 MAPK6 12460732 1021928 The kinase inhibitor PD 98059 *blocked* palytoxin stimulated [ERK] activation . Positive_regulation EPHB2 MAPK6 12511425 1070729 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation EPHB2 MAPK6 12527329 1048271 The inhibitor U0126 ( 10 microM ) , while *preventing* [ERK] phosphorylation in MDA-MB-468 cells , did not induce apoptosis . Positive_regulation EPHB2 MAPK6 12753285 1089633 Inhibition of PKA by H89 strikingly decreased cAMP stimulated phosphorylation of [ERK] and B-Raf , and inhibition by PD98059 *blocked* the effect of the nucleotide to activate ERK . Positive_regulation EPHB2 MAPK6 12946695 1136849 [ERK] *activation* by the leading to cyclic-AMP response element binding protein ( CREB ) phosphorylation is implicated in the formation of long-term memory . Positive_regulation EPHB2 MAPK6 14514663 1185740 Furthermore , two specific inhibitors ( SP600125 for JNK and UO126 for ERK ) could specifically *block* the activation of JNK and [ERK] and cell transformation . Positive_regulation EPHB2 MAPK6 14647418 1210378 These events were accompanied by the caspase independent downregulation of Raf-1 , inactivation of MEK1/2 , [ERK] , Akt , p70S6K , dephosphorylation of GSK-3 , and *activation* of c-Jun-N-terminal kinase (JNK) and p38 . Positive_regulation EPHB2 MAPK6 14648542 1188342 LPA- and S1P induced [ERK] phosphorylation was *dependent* on the activation of , phospholipase C (PLC) , and protein kinase C ( PKC ) , but was insensitive to pertussis toxin (PTX) . Positive_regulation EPHB2 MAPK6 14973553 1212497 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 MAPK6 14998726 1216721 Furthermore , we found that PD98059 , an [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation EPHB2 MAPK6 15102758 1239914 The inhibition of ERK by the specific inhibitor PD 98059 significantly *reduced* [phospho-ERK44/42] MAPK levels induced by C. albicans supernatant fluids in the IFN-gamma-plus-LPS-driven monocytes . Positive_regulation EPHB2 MAPK6 15147892 1248188 These findings strongly suggest that HHE induces NF-kappaB activation through IKK/NIK pathway and/or p38 and [ERK] *activation* associated with oxidative stress in endothelial cells . Positive_regulation EPHB2 MAPK6 15271999 1296263 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation EPHB2 MAPK6 15659876 1350294 The anabolic effect of TNF-alpha was *mediated* at least in part by , especially by an [extracellular regulated kinases (ERK)] . Positive_regulation EPHB2 MAPK6 16464862 1548080 c-Fos hyperphosphorylation at threonine 325 was found to parallel this p38 *mediated* modulation of [ERK] activation . Positive_regulation EPHB2 MAPK6 16920714 1626742 Overall , our results suggest that intracellular HIV-Tat induces IL-10 transcription by [ERK] *dependent* CREB-1 transcription factor activation through Ser ( 133 ) phosphorylation . Positive_regulation EPHB2 MAPK6 17255201 1725208 Prolactin *induced* phosphorylation of JAK2 and [ERK] , whereas IFN-gamma induced phosphorylation of JAK1 , JAK2 , and p38 . Positive_regulation EPHB2 MAPK6 18164124 1869602 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 , but not by the *activation* of JNK , [ERK] , and NF-kappaB pathway . Positive_regulation EPHB2 MAPK6 18285354 1885398 Pre-treatment with the inhibitors SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( [ERK] *inhibitor* ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation EPHB2 MAPK6 18401006 1925765 CyaA enhanced LPS induced phosphorylation of p38 MAPK and [ERK] in DC , and inhibitors of p38 , MEK , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation EPHB2 MAPK6 18413315 1920484 Furthermore , a inhibitor , PD98059 , *blocked* the eena induced cell proliferation and activation of [ERK] signaling . Positive_regulation EPHB2 MAPK6 18520049 1918665 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of [ERK] , rather than by the *activation* of p38 , in the spinal cord . Positive_regulation EPHB2 MAPK6 19022376 2016967 A inhibitor *reduced* [ERK] phosphorylation in cells with reduced expression of A-type lamins and emerin . Positive_regulation EPHB2 MAPK6 19276187 2051410 Treatment of cells with sphingosine induced suppression of [ERK] and *activation* of p38 . Positive_regulation EPHB2 MAPK6 19429670 2106910 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either [ERK] *inhibitor* , inhibitor or NF-kappaB inhibitor . Positive_regulation EPHB2 MAPK6 19433984 2096496 S1P stimulation of [ERK] was completely *inhibited* by an S1P1/3 subtype receptor antagonist ( VPC23019 ) , by a Gi protein inhibitor ( pertussis toxin ) and by a kinase inhibitor ( PD98059 ) . Positive_regulation EPHB2 MAPK6 19522739 2103133 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation EPHB2 MAPK6 19803745 2232103 Butyrate treatment increased the phosphorylation of [ERK] , not p38 MAPK and JNK , but inhibition of ERK and p38 phosphorylation did not *inhibit* butyrate reduced cell viability . Positive_regulation EPHB2 MAPK6 19879308 2196982 The administration of curcumin led to increased levels of [phosphor-ERK] and AKT , which were each *blocked* by and PI-3K inhibitors . Positive_regulation EPHB2 MAPK6 20025124 2175505 Prior treatment of the cells with PD98059 , an [ERK] kinase *inhibitor* or SB203580 , a inhibitor , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation EPHB2 MAPK6 21126656 2355791 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by [ERK] . Positive_regulation EPHB2 MAPK6 21311676 2360026 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation EPHB2 MAPK6 21488184 2417965 Dexmedetomidine induced phosphorylation of JNK and p38 in rat aortic SMCs , but did not *induce* phosphorylation of [ERK] . Positive_regulation EPHB2 MAPK6 21558315 2445095 The blockade of cAMP *induced* [kinase/ERK] activation abated MKP-1 phosphorylation but only partially reduced flag-MKP-1 protein accumulation . Positive_regulation EPHB2 MAPK6 21720001 2451708 kinase inhibitor , PD98059 ( 10 ( -6 ) M ) , completely *inhibited* the PDGF induced increase in [ERK] activity . Positive_regulation EPHB2 MAPK6 22687715 2669874 Moreover , P. brasiliensis yeasts induced activation of p38 mitogen activated protein kinase (MAPK) , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and extracellular signal regulated kinase ( [ERK] ) 1/2 in A549 cells , and IL-8 and IL-6 secretion promoted by this fungus was *dependent* on activation of p38 and ERK 1/2 . Positive_regulation EPHB2 MAPK6 23207235 2705348 In addition , the phosphorylation levels of [ERK] and JNK were *induced* in macrophages at 15 min after LPS stimulation , while the phosphorylation level of p38 was induced at 1 h ; Positive_regulation EPHB2 MAPK6 23772367 2714512 VN attenuated radiation induced expression of p21 , an inhibitor of cell cycle progression , and selectively inhibited [Erk-] and p38 *dependent* p21 induction after radiation exposure through regulation of the activity of GSK-3ß . Positive_regulation EPHB2 MAPK6 23892041 2830327 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three inhibitors ( [ERK] inhibitor PD98059 , JNK inhibitor SP600125 and p38 *inhibitor* SB203580 ) . Positive_regulation EPHB2 MAPK6 23914844 2840563 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of [ERK] , JNK , NF-?B . Positive_regulation EPHB2 MAPK6 24225419 2897487 Therefore , by using the inhibitors SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific [ERK] *inhibitor* ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation EPHB2 MAPK6 24297112 2894206 Following treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation EPHB2 MAPK7 10207619 606850 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by and MEKs , in turn , are regulated by MAPK kinase kinases (MAPKKKs) . Positive_regulation EPHB2 MAPK7 10501195 648318 Inhibition of p38 MAPK had no significant effect on opioid induced ERK activation , indicating that p38 activity was not *required* for [ERK] activation , though its stimulation preceded ERK activation . Positive_regulation EPHB2 MAPK7 10872747 707018 Pre-treatment of the cells with PD98059 , a selective [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation EPHB2 MAPK7 11360180 816766 These data are consistent with a model where thrombin *induces* [ERK] activation via both PKC dependent and independent pathways , whereas p38 activation requires only PTKs . Positive_regulation EPHB2 MAPK7 11409852 826382 kinase inhibitors PD098059 and U0126 *prevent* [ERK] ( 1/2 ) phosphorylation by Tat . Positive_regulation EPHB2 MAPK7 11546664 856584 The kinase ( MEK ) inhibitors , PD-98059 and U-0126 , *blocked* IL-1 alpha induced [ERK] activation and partially attenuated cPLA(2)alpha phosphorylation and PGI ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation EPHB2 MAPK7 12386816 999756 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 and a biphasic *activation* of [ERK] . Positive_regulation EPHB2 MAPK7 12403788 1036168 SB203580 , a p38 inhibitor , and PD98059 , an [ERK] *inhibitor* , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation EPHB2 MAPK7 12450322 1018709 In summary , in H295R cells , ANG II activated [ERK] and p38 MAPKs , ANG II-induced p38 MAPK was mediated by 12-LO activation , and ANG II-induced aldosterone synthesis was *prevented* by 12-LO- and p38 inhibitors . Positive_regulation EPHB2 MAPK7 12460732 1021929 The kinase inhibitor PD 98059 *blocked* palytoxin stimulated [ERK] activation . Positive_regulation EPHB2 MAPK7 12511425 1070730 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation EPHB2 MAPK7 12527329 1048272 The inhibitor U0126 ( 10 microM ) , while *preventing* [ERK] phosphorylation in MDA-MB-468 cells , did not induce apoptosis . Positive_regulation EPHB2 MAPK7 12753285 1089634 Inhibition of PKA by H89 strikingly decreased cAMP stimulated phosphorylation of [ERK] and B-Raf , and inhibition by PD98059 *blocked* the effect of the nucleotide to activate ERK . Positive_regulation EPHB2 MAPK7 12946695 1136850 [ERK] *activation* by the leading to cyclic-AMP response element binding protein ( CREB ) phosphorylation is implicated in the formation of long-term memory . Positive_regulation EPHB2 MAPK7 14514663 1185741 Furthermore , two specific inhibitors ( SP600125 for JNK and UO126 for ERK ) could specifically *block* the activation of JNK and [ERK] and cell transformation . Positive_regulation EPHB2 MAPK7 14647418 1210379 These events were accompanied by the caspase independent downregulation of Raf-1 , inactivation of MEK1/2 , [ERK] , Akt , p70S6K , dephosphorylation of GSK-3 , and *activation* of c-Jun-N-terminal kinase (JNK) and p38 . Positive_regulation EPHB2 MAPK7 14648542 1188343 LPA- and S1P induced [ERK] phosphorylation was *dependent* on the activation of , phospholipase C (PLC) , and protein kinase C ( PKC ) , but was insensitive to pertussis toxin (PTX) . Positive_regulation EPHB2 MAPK7 14973553 1212498 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 MAPK7 14998726 1216722 Furthermore , we found that PD98059 , an [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation EPHB2 MAPK7 15102758 1239915 The inhibition of ERK by the specific inhibitor PD 98059 significantly *reduced* [phospho-ERK44/42] MAPK levels induced by C. albicans supernatant fluids in the IFN-gamma-plus-LPS-driven monocytes . Positive_regulation EPHB2 MAPK7 15147892 1248189 These findings strongly suggest that HHE induces NF-kappaB activation through IKK/NIK pathway and/or p38 and [ERK] *activation* associated with oxidative stress in endothelial cells . Positive_regulation EPHB2 MAPK7 15271999 1296264 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation EPHB2 MAPK7 15659876 1350295 The anabolic effect of TNF-alpha was *mediated* at least in part by , especially by an [extracellular regulated kinases (ERK)] . Positive_regulation EPHB2 MAPK7 16464862 1548081 c-Fos hyperphosphorylation at threonine 325 was found to parallel this p38 *mediated* modulation of [ERK] activation . Positive_regulation EPHB2 MAPK7 16920714 1626743 Overall , our results suggest that intracellular HIV-Tat induces IL-10 transcription by [ERK] dependent CREB-1 transcription factor *activation* through Ser ( 133 ) phosphorylation . Positive_regulation EPHB2 MAPK7 17255201 1725209 Prolactin *induced* phosphorylation of JAK2 and [ERK] , whereas IFN-gamma induced phosphorylation of JAK1 , JAK2 , and p38 . Positive_regulation EPHB2 MAPK7 18164124 1869603 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 , but not by the *activation* of JNK , [ERK] , and NF-kappaB pathway . Positive_regulation EPHB2 MAPK7 18285354 1885399 Pre-treatment with the inhibitors SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( [ERK] *inhibitor* ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation EPHB2 MAPK7 18401006 1925766 CyaA enhanced LPS induced phosphorylation of p38 MAPK and [ERK] in DC , and inhibitors of p38 , MEK , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation EPHB2 MAPK7 18413315 1920485 Furthermore , a inhibitor , PD98059 , *blocked* the eena induced cell proliferation and activation of [ERK] signaling . Positive_regulation EPHB2 MAPK7 18520049 1918666 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of [ERK] , rather than by the *activation* of p38 , in the spinal cord . Positive_regulation EPHB2 MAPK7 19022376 2016968 A inhibitor *reduced* [ERK] phosphorylation in cells with reduced expression of A-type lamins and emerin . Positive_regulation EPHB2 MAPK7 19276187 2051411 Treatment of cells with sphingosine induced suppression of [ERK] and *activation* of p38 . Positive_regulation EPHB2 MAPK7 19429670 2106911 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either [ERK] *inhibitor* , inhibitor or NF-kappaB inhibitor . Positive_regulation EPHB2 MAPK7 19433984 2096497 S1P stimulation of [ERK] was completely *inhibited* by an S1P1/3 subtype receptor antagonist ( VPC23019 ) , by a Gi protein inhibitor ( pertussis toxin ) and by a kinase inhibitor ( PD98059 ) . Positive_regulation EPHB2 MAPK7 19522739 2103134 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation EPHB2 MAPK7 19803745 2232104 Butyrate treatment increased the phosphorylation of [ERK] , not p38 MAPK and JNK , but inhibition of ERK and p38 phosphorylation did not *inhibit* butyrate reduced cell viability . Positive_regulation EPHB2 MAPK7 19879308 2196983 The administration of curcumin led to increased levels of [phosphor-ERK] and AKT , which were each *blocked* by and PI-3K inhibitors . Positive_regulation EPHB2 MAPK7 20025124 2175506 Prior treatment of the cells with PD98059 , an [ERK] kinase *inhibitor* or SB203580 , a inhibitor , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation EPHB2 MAPK7 21126656 2355792 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by [ERK] . Positive_regulation EPHB2 MAPK7 21311676 2360027 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation EPHB2 MAPK7 21488184 2417966 Dexmedetomidine induced phosphorylation of JNK and p38 in rat aortic SMCs , but did not *induce* phosphorylation of [ERK] . Positive_regulation EPHB2 MAPK7 21558315 2445096 The blockade of cAMP *induced* [kinase/ERK] activation abated MKP-1 phosphorylation but only partially reduced flag-MKP-1 protein accumulation . Positive_regulation EPHB2 MAPK7 21720001 2451709 kinase inhibitor , PD98059 ( 10 ( -6 ) M ) , completely *inhibited* the PDGF induced increase in [ERK] activity . Positive_regulation EPHB2 MAPK7 22687715 2669875 Moreover , P. brasiliensis yeasts induced activation of p38 mitogen activated protein kinase (MAPK) , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and extracellular signal regulated kinase ( [ERK] ) 1/2 in A549 cells , and IL-8 and IL-6 secretion promoted by this fungus was *dependent* on activation of p38 and ERK 1/2 . Positive_regulation EPHB2 MAPK7 23207235 2705349 In addition , the phosphorylation levels of [ERK] and JNK were *induced* in macrophages at 15 min after LPS stimulation , while the phosphorylation level of p38 was induced at 1 h ; Positive_regulation EPHB2 MAPK7 23772367 2714513 VN attenuated radiation induced expression of p21 , an inhibitor of cell cycle progression , and selectively inhibited [Erk-] and p38 dependent p21 *induction* after radiation exposure through regulation of the activity of GSK-3ß . Positive_regulation EPHB2 MAPK7 23892041 2830328 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three inhibitors ( [ERK] inhibitor PD98059 , JNK inhibitor SP600125 and p38 *inhibitor* SB203580 ) . Positive_regulation EPHB2 MAPK7 23914844 2840564 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of [ERK] , JNK , NF-?B . Positive_regulation EPHB2 MAPK7 24225419 2897488 Therefore , by using the inhibitors SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific [ERK] *inhibitor* ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation EPHB2 MAPK7 24297112 2894207 Following treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation EPHB2 MAPK8 10207619 606851 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by and MEKs , in turn , are regulated by MAPK kinase kinases (MAPKKKs) . Positive_regulation EPHB2 MAPK8 10501195 648319 Inhibition of p38 MAPK had no significant effect on opioid induced ERK activation , indicating that p38 activity was not *required* for [ERK] activation , though its stimulation preceded ERK activation . Positive_regulation EPHB2 MAPK8 10872747 707019 Pre-treatment of the cells with PD98059 , a selective [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation EPHB2 MAPK8 11360180 816767 These data are consistent with a model where thrombin *induces* [ERK] activation via both PKC dependent and independent pathways , whereas p38 activation requires only PTKs . Positive_regulation EPHB2 MAPK8 11409852 826383 kinase inhibitors PD098059 and U0126 *prevent* [ERK] ( 1/2 ) phosphorylation by Tat . Positive_regulation EPHB2 MAPK8 11546664 856585 The kinase ( MEK ) inhibitors , PD-98059 and U-0126 , *blocked* IL-1 alpha induced [ERK] activation and partially attenuated cPLA(2)alpha phosphorylation and PGI ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation EPHB2 MAPK8 12386816 999757 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 and a biphasic *activation* of [ERK] . Positive_regulation EPHB2 MAPK8 12403788 1036169 SB203580 , a p38 inhibitor , and PD98059 , an [ERK] *inhibitor* , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation EPHB2 MAPK8 12450322 1018710 In summary , in H295R cells , ANG II activated [ERK] and p38 MAPKs , ANG II-induced p38 MAPK was mediated by 12-LO activation , and ANG II-induced aldosterone synthesis was *prevented* by 12-LO- and p38 inhibitors . Positive_regulation EPHB2 MAPK8 12460732 1021930 The kinase inhibitor PD 98059 *blocked* palytoxin stimulated [ERK] activation . Positive_regulation EPHB2 MAPK8 12511425 1070731 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation EPHB2 MAPK8 12527329 1048273 The inhibitor U0126 ( 10 microM ) , while *preventing* [ERK] phosphorylation in MDA-MB-468 cells , did not induce apoptosis . Positive_regulation EPHB2 MAPK8 12753285 1089635 Inhibition of PKA by H89 strikingly decreased cAMP stimulated phosphorylation of [ERK] and B-Raf , and inhibition by PD98059 *blocked* the effect of the nucleotide to activate ERK . Positive_regulation EPHB2 MAPK8 12946695 1136851 [ERK] *activation* by the leading to cyclic-AMP response element binding protein ( CREB ) phosphorylation is implicated in the formation of long-term memory . Positive_regulation EPHB2 MAPK8 14514663 1185742 Furthermore , two specific inhibitors ( SP600125 for JNK and UO126 for ERK ) could specifically *block* the activation of JNK and [ERK] and cell transformation . Positive_regulation EPHB2 MAPK8 14647418 1210380 These events were accompanied by the caspase independent downregulation of Raf-1 , inactivation of MEK1/2 , [ERK] , Akt , p70S6K , dephosphorylation of GSK-3 , and *activation* of c-Jun-N-terminal kinase (JNK) and p38 . Positive_regulation EPHB2 MAPK8 14648542 1188344 LPA- and S1P induced [ERK] phosphorylation was *dependent* on the activation of , phospholipase C (PLC) , and protein kinase C ( PKC ) , but was insensitive to pertussis toxin (PTX) . Positive_regulation EPHB2 MAPK8 14973553 1212499 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 MAPK8 14998726 1216723 Furthermore , we found that PD98059 , an [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation EPHB2 MAPK8 15102758 1239916 The inhibition of ERK by the specific inhibitor PD 98059 significantly *reduced* [phospho-ERK44/42] MAPK levels induced by C. albicans supernatant fluids in the IFN-gamma-plus-LPS-driven monocytes . Positive_regulation EPHB2 MAPK8 15147892 1248190 These findings strongly suggest that HHE induces NF-kappaB activation through IKK/NIK pathway and/or p38 and [ERK] *activation* associated with oxidative stress in endothelial cells . Positive_regulation EPHB2 MAPK8 15271999 1296265 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation EPHB2 MAPK8 15659876 1350296 The anabolic effect of TNF-alpha was *mediated* at least in part by , especially by an [extracellular regulated kinases (ERK)] . Positive_regulation EPHB2 MAPK8 16464862 1548082 c-Fos hyperphosphorylation at threonine 325 was found to parallel this p38 *mediated* modulation of [ERK] activation . Positive_regulation EPHB2 MAPK8 16920714 1626744 Overall , our results suggest that intracellular HIV-Tat induces IL-10 transcription by [ERK] *dependent* CREB-1 transcription factor activation through Ser ( 133 ) phosphorylation . Positive_regulation EPHB2 MAPK8 17255201 1725210 Prolactin *induced* phosphorylation of JAK2 and [ERK] , whereas IFN-gamma induced phosphorylation of JAK1 , JAK2 , and p38 . Positive_regulation EPHB2 MAPK8 18164124 1869604 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 , but not by the *activation* of JNK , [ERK] , and NF-kappaB pathway . Positive_regulation EPHB2 MAPK8 18285354 1885400 Pre-treatment with the inhibitors SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( [ERK] *inhibitor* ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation EPHB2 MAPK8 18401006 1925767 CyaA enhanced LPS induced phosphorylation of p38 MAPK and [ERK] in DC , and inhibitors of p38 , MEK , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation EPHB2 MAPK8 18413315 1920486 Furthermore , a inhibitor , PD98059 , *blocked* the eena induced cell proliferation and activation of [ERK] signaling . Positive_regulation EPHB2 MAPK8 18520049 1918667 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of [ERK] , rather than by the *activation* of p38 , in the spinal cord . Positive_regulation EPHB2 MAPK8 19022376 2016969 A inhibitor *reduced* [ERK] phosphorylation in cells with reduced expression of A-type lamins and emerin . Positive_regulation EPHB2 MAPK8 19276187 2051412 Treatment of cells with sphingosine induced suppression of [ERK] and *activation* of p38 . Positive_regulation EPHB2 MAPK8 19429670 2106912 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either [ERK] *inhibitor* , inhibitor or NF-kappaB inhibitor . Positive_regulation EPHB2 MAPK8 19433984 2096498 S1P stimulation of [ERK] was completely *inhibited* by an S1P1/3 subtype receptor antagonist ( VPC23019 ) , by a Gi protein inhibitor ( pertussis toxin ) and by a kinase inhibitor ( PD98059 ) . Positive_regulation EPHB2 MAPK8 19522739 2103135 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation EPHB2 MAPK8 19803745 2232105 Butyrate treatment increased the phosphorylation of [ERK] , not p38 MAPK and JNK , but inhibition of ERK and p38 phosphorylation did not *inhibit* butyrate reduced cell viability . Positive_regulation EPHB2 MAPK8 19879308 2196984 The administration of curcumin led to increased levels of [phosphor-ERK] and AKT , which were each *blocked* by and PI-3K inhibitors . Positive_regulation EPHB2 MAPK8 20025124 2175507 Prior treatment of the cells with PD98059 , an [ERK] kinase *inhibitor* or SB203580 , a inhibitor , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation EPHB2 MAPK8 21126656 2355793 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by [ERK] . Positive_regulation EPHB2 MAPK8 21311676 2360028 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation EPHB2 MAPK8 21488184 2417967 Dexmedetomidine induced phosphorylation of JNK and p38 in rat aortic SMCs , but did not *induce* phosphorylation of [ERK] . Positive_regulation EPHB2 MAPK8 21558315 2445097 The blockade of cAMP *induced* [kinase/ERK] activation abated MKP-1 phosphorylation but only partially reduced flag-MKP-1 protein accumulation . Positive_regulation EPHB2 MAPK8 21720001 2451710 kinase inhibitor , PD98059 ( 10 ( -6 ) M ) , completely *inhibited* the PDGF induced increase in [ERK] activity . Positive_regulation EPHB2 MAPK8 22687715 2669876 Moreover , P. brasiliensis yeasts induced activation of p38 mitogen activated protein kinase (MAPK) , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and extracellular signal regulated kinase ( [ERK] ) 1/2 in A549 cells , and IL-8 and IL-6 secretion promoted by this fungus was *dependent* on activation of p38 and ERK 1/2 . Positive_regulation EPHB2 MAPK8 23207235 2705350 In addition , the phosphorylation levels of [ERK] and JNK were *induced* in macrophages at 15 min after LPS stimulation , while the phosphorylation level of p38 was induced at 1 h ; Positive_regulation EPHB2 MAPK8 23772367 2714514 VN attenuated radiation induced expression of p21 , an inhibitor of cell cycle progression , and selectively inhibited [Erk-] and p38 *dependent* p21 induction after radiation exposure through regulation of the activity of GSK-3ß . Positive_regulation EPHB2 MAPK8 23892041 2830329 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three inhibitors ( [ERK] inhibitor PD98059 , JNK inhibitor SP600125 and p38 *inhibitor* SB203580 ) . Positive_regulation EPHB2 MAPK8 23914844 2840565 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of [ERK] , JNK , NF-?B . Positive_regulation EPHB2 MAPK8 24225419 2897489 Therefore , by using the inhibitors SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific [ERK] *inhibitor* ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation EPHB2 MAPK8 24297112 2894208 Following treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation EPHB2 MAPK8IP3 21156008 2373407 Biochemical analyses of transfected cells showed that activated FGFR increased JSAP1 's affinity for JNK and ERK and that *enhanced* FGFR induced JNK and [ERK] activation . Positive_regulation EPHB2 MAPK9 10207619 606852 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by and MEKs , in turn , are regulated by MAPK kinase kinases (MAPKKKs) . Positive_regulation EPHB2 MAPK9 10501195 648320 Inhibition of p38 MAPK had no significant effect on opioid induced ERK activation , indicating that p38 activity was not *required* for [ERK] activation , though its stimulation preceded ERK activation . Positive_regulation EPHB2 MAPK9 10872747 707020 Pre-treatment of the cells with PD98059 , a selective [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation EPHB2 MAPK9 11360180 816768 These data are consistent with a model where thrombin *induces* [ERK] activation via both PKC dependent and independent pathways , whereas p38 activation requires only PTKs . Positive_regulation EPHB2 MAPK9 11409852 826384 kinase inhibitors PD098059 and U0126 *prevent* [ERK] ( 1/2 ) phosphorylation by Tat . Positive_regulation EPHB2 MAPK9 11546664 856586 The kinase ( MEK ) inhibitors , PD-98059 and U-0126 , *blocked* IL-1 alpha induced [ERK] activation and partially attenuated cPLA(2)alpha phosphorylation and PGI ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation EPHB2 MAPK9 12386816 999758 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 and a biphasic *activation* of [ERK] . Positive_regulation EPHB2 MAPK9 12403788 1036170 SB203580 , a p38 inhibitor , and PD98059 , an [ERK] *inhibitor* , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation EPHB2 MAPK9 12450322 1018711 In summary , in H295R cells , ANG II activated [ERK] and p38 MAPKs , ANG II-induced p38 MAPK was mediated by 12-LO activation , and ANG II-induced aldosterone synthesis was *prevented* by 12-LO- and p38 inhibitors . Positive_regulation EPHB2 MAPK9 12460732 1021931 The kinase inhibitor PD 98059 *blocked* palytoxin stimulated [ERK] activation . Positive_regulation EPHB2 MAPK9 12511425 1070732 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation EPHB2 MAPK9 12527329 1048274 The inhibitor U0126 ( 10 microM ) , while *preventing* [ERK] phosphorylation in MDA-MB-468 cells , did not induce apoptosis . Positive_regulation EPHB2 MAPK9 12753285 1089636 Inhibition of PKA by H89 strikingly decreased cAMP stimulated phosphorylation of [ERK] and B-Raf , and inhibition by PD98059 *blocked* the effect of the nucleotide to activate ERK . Positive_regulation EPHB2 MAPK9 12946695 1136852 [ERK] *activation* by the leading to cyclic-AMP response element binding protein ( CREB ) phosphorylation is implicated in the formation of long-term memory . Positive_regulation EPHB2 MAPK9 14514663 1185743 Furthermore , two specific inhibitors ( SP600125 for JNK and UO126 for ERK ) could specifically *block* the activation of JNK and [ERK] and cell transformation . Positive_regulation EPHB2 MAPK9 14647418 1210381 These events were accompanied by the caspase independent downregulation of Raf-1 , inactivation of MEK1/2 , [ERK] , Akt , p70S6K , dephosphorylation of GSK-3 , and *activation* of c-Jun-N-terminal kinase (JNK) and p38 . Positive_regulation EPHB2 MAPK9 14648542 1188345 LPA- and S1P induced [ERK] phosphorylation was *dependent* on the activation of , phospholipase C (PLC) , and protein kinase C ( PKC ) , but was insensitive to pertussis toxin (PTX) . Positive_regulation EPHB2 MAPK9 14973553 1212500 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen] activated protein kinase (MAPK) signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation EPHB2 MAPK9 14998726 1216724 Furthermore , we found that PD98059 , an [ERK] pathway *inhibitor* , and SB203580 , a p38 inhibitor , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation EPHB2 MAPK9 15102758 1239917 The inhibition of ERK by the specific inhibitor PD 98059 significantly *reduced* [phospho-ERK44/42] MAPK levels induced by C. albicans supernatant fluids in the IFN-gamma-plus-LPS-driven monocytes . Positive_regulation EPHB2 MAPK9 15147892 1248191 These findings strongly suggest that HHE induces NF-kappaB activation through IKK/NIK pathway and/or p38 and [ERK] *activation* associated with oxidative stress in endothelial cells . Positive_regulation EPHB2 MAPK9 15271999 1296266 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation EPHB2 MAPK9 15659876 1350297 The anabolic effect of TNF-alpha was *mediated* at least in part by , especially by an [extracellular regulated kinases (ERK)] . Positive_regulation EPHB2 MAPK9 16464862 1548083 c-Fos hyperphosphorylation at threonine 325 was found to parallel this p38 *mediated* modulation of [ERK] activation . Positive_regulation EPHB2 MAPK9 16920714 1626745 Overall , our results suggest that intracellular HIV-Tat induces IL-10 transcription by [ERK] dependent CREB-1 transcription factor *activation* through Ser ( 133 ) phosphorylation . Positive_regulation EPHB2 MAPK9 17255201 1725211 Prolactin *induced* phosphorylation of JAK2 and [ERK] , whereas IFN-gamma induced phosphorylation of JAK1 , JAK2 , and p38 . Positive_regulation EPHB2 MAPK9 18164124 1869605 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 , but not by the *activation* of JNK , [ERK] , and NF-kappaB pathway . Positive_regulation EPHB2 MAPK9 18285354 1885401 Pre-treatment with the inhibitors SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( [ERK] *inhibitor* ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation EPHB2 MAPK9 18401006 1925768 CyaA enhanced LPS induced phosphorylation of p38 MAPK and [ERK] in DC , and inhibitors of p38 , MEK , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation EPHB2 MAPK9 18413315 1920487 Furthermore , a inhibitor , PD98059 , *blocked* the eena induced cell proliferation and activation of [ERK] signaling . Positive_regulation EPHB2 MAPK9 18520049 1918668 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of [ERK] , rather than by the *activation* of p38 , in the spinal cord . Positive_regulation EPHB2 MAPK9 19022376 2016970 A inhibitor *reduced* [ERK] phosphorylation in cells with reduced expression of A-type lamins and emerin . Positive_regulation EPHB2 MAPK9 19276187 2051413 Treatment of cells with sphingosine induced suppression of [ERK] and *activation* of p38 . Positive_regulation EPHB2 MAPK9 19429670 2106913 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either [ERK] *inhibitor* , inhibitor or NF-kappaB inhibitor . Positive_regulation EPHB2 MAPK9 19433984 2096499 S1P stimulation of [ERK] was completely *inhibited* by an S1P1/3 subtype receptor antagonist ( VPC23019 ) , by a Gi protein inhibitor ( pertussis toxin ) and by a kinase inhibitor ( PD98059 ) . Positive_regulation EPHB2 MAPK9 19522739 2103136 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation EPHB2 MAPK9 19803745 2232106 Butyrate treatment increased the phosphorylation of [ERK] , not p38 MAPK and JNK , but inhibition of ERK and p38 phosphorylation did not *inhibit* butyrate reduced cell viability . Positive_regulation EPHB2 MAPK9 19879308 2196985 The administration of curcumin led to increased levels of [phosphor-ERK] and AKT , which were each *blocked* by and PI-3K inhibitors . Positive_regulation EPHB2 MAPK9 20025124 2175508 Prior treatment of the cells with PD98059 , an [ERK] kinase *inhibitor* or SB203580 , a inhibitor , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation EPHB2 MAPK9 21126656 2355794 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by [ERK] . Positive_regulation EPHB2 MAPK9 21311676 2360029 Treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation EPHB2 MAPK9 21488184 2417968 Dexmedetomidine induced phosphorylation of JNK and p38 in rat aortic SMCs , but did not *induce* phosphorylation of [ERK] . Positive_regulation EPHB2 MAPK9 21558315 2445098 The blockade of cAMP *induced* [kinase/ERK] activation abated MKP-1 phosphorylation but only partially reduced flag-MKP-1 protein accumulation . Positive_regulation EPHB2 MAPK9 21720001 2451711 kinase inhibitor , PD98059 ( 10 ( -6 ) M ) , completely *inhibited* the PDGF induced increase in [ERK] activity . Positive_regulation EPHB2 MAPK9 22687715 2669877 Moreover , P. brasiliensis yeasts induced activation of p38 mitogen activated protein kinase (MAPK) , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and extracellular signal regulated kinase ( [ERK] ) 1/2 in A549 cells , and IL-8 and IL-6 secretion promoted by this fungus was *dependent* on activation of p38 and ERK 1/2 . Positive_regulation EPHB2 MAPK9 23207235 2705351 In addition , the phosphorylation levels of [ERK] and JNK were *induced* in macrophages at 15 min after LPS stimulation , while the phosphorylation level of p38 was induced at 1 h ; Positive_regulation EPHB2 MAPK9 23772367 2714515 VN attenuated radiation induced expression of p21 , an inhibitor of cell cycle progression , and selectively inhibited [Erk-] and p38 dependent p21 *induction* after radiation exposure through regulation of the activity of GSK-3ß . Positive_regulation EPHB2 MAPK9 23892041 2830330 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three inhibitors ( [ERK] inhibitor PD98059 , JNK inhibitor SP600125 and p38 *inhibitor* SB203580 ) . Positive_regulation EPHB2 MAPK9 23914844 2840566 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of [ERK] , JNK , NF-?B . Positive_regulation EPHB2 MAPK9 24225419 2897490 Therefore , by using the inhibitors SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific [ERK] *inhibitor* ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation EPHB2 MAPK9 24297112 2894209 Following treatment with inhibitors , PD98059 ( [ERK] *inhibitor* ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation EPHB2 MAPKAP1 10648884 662342 However , sodium nitroprusside and , known to release NO , dose-dependently *activated* only [ERK] . Positive_regulation EPHB2 MAPKAP1 20512842 2270564 In this report , we focused on studying the *role* of mTORC1 and in rapamycin mediated Akt and [ERK] phosphorylation , and the antitumor effect of rapamycin in cancer cells in combination with Akt and ERK inhibitors . Positive_regulation EPHB2 MAPKAPK2 14499342 1143747 These data suggest that *mediates* both [ERK-] and p38 MAPK dependent neutrophil responses . Positive_regulation EPHB2 MAPRE2 17372305 1713815 however , selective inhibition of the with AG825 or small interfering RNA ( siRNA ) *blocked* low but not high EGF activation of [ERK] and p38 . Positive_regulation EPHB2 MBP 22627361 2604300 Furthermore , *induced* the phosphorylation of the extracellular signal regulated kinase ( [ERK] ) 1/2 , p38 mitogen activated protein kinase (MAPK) , Jun-N-terminal protein kinase (JNK) , and signal transducer and activator of transcription ( STAT ) 3 in the infected cells . Positive_regulation EPHB2 MBTPS1 12138095 991535 Cell survival relied on two pertussis toxin-sensitive events , activation of [ERK] and *activation* of phosphatidylinositol 3-kinase (PI3K)/Akt by . Positive_regulation EPHB2 MBTPS1 12149127 997546 , in a time- and dose dependent manner , *enhanced* the threonine/tyrosine phosphorylation of [ERK] . Positive_regulation EPHB2 MBTPS1 12149127 997547 The inhibition of *induced* [ERK] phosphorylation by pertussis toxin and PD 98059 indicated coupling of S1P receptors to G ( i ) and the ERK signalling cascade respectively . Positive_regulation EPHB2 MBTPS1 12149127 997548 Treatment of Beas-2B cells with butan-1-ol , but not butan-3-ol , abrogated the *induced* phosphorylation of Raf-1 and [ERK] , suggesting that PLD is involved in this activation . Positive_regulation EPHB2 MBTPS1 12197778 981945 [ERK] *activation* by is not required for its mitogenic effect . Positive_regulation EPHB2 MBTPS1 12385647 1034939 [ERK] *activation* by IGF-I as well as was dependent on Ras , but Akt activation by IGF-I was not dependent on Ras . Positive_regulation EPHB2 MBTPS1 12665551 1074808 In addition , we found that *induces* the sustained activation of [ERK] and the subsequent degradation of microphthalmia associated transcription factor ( MITF ) , which plays a key role in melanogenesis . Positive_regulation EPHB2 MBTPS1 12665551 1074812 These results indicate that the ERK pathway is potently involved in the melanogenic signaling cascade , and that *induced* [ERK] activation contributes to reduced melanin synthesis via MITF degradation . Positive_regulation EPHB2 MBTPS1 14560924 1154183 In contrast , clearly *stimulated* the phosphorylation of [ERK] , and the specific inhibition of the ERK pathway using PD98059 abolished the cytoprotective effect of S1P . Positive_regulation EPHB2 MBTPS1 14648542 1188331 LPA- and *induced* [ERK] phosphorylation was dependent on the activation of mitogen activated protein kinase (MAPK) , phospholipase C (PLC) , and protein kinase C ( PKC ) , but was insensitive to pertussis toxin (PTX) . Positive_regulation EPHB2 MBTPS1 14657000 1202013 In addition , *stimulated* activation of Akt , but not [ERK] , was blocked by a PDGF receptor (PDGFR)-specific inhibitor , AG1296 , suggesting a S1P3 mediated specific crosstalk between the Akt signaling pathways of S1P and PDGFR in MEFs . Positive_regulation EPHB2 MBTPS1 14657000 1202025 We investigated this crosstalk under different conditions and found that both Akt and [ERK] activation *induced* by , but not lysophosphatidic acid (LPA) , in HEY ovarian cancer cells required PDGFR but not epidermal growth factor receptor (EGFR) or insulin-like growth factor-I receptor ( IGFR ) . Positive_regulation EPHB2 MBTPS1 14742298 1242752 *activated* Akt and [ERK] within minutes , and inhibition of sphingosine kinase blocked RSV induced ERK and Akt activation , leading to accelerated cell death after viral infection . Positive_regulation EPHB2 MBTPS1 15044318 1237377 *Activation* of extracellular signal regulated kinase ( [ERK] ) 1 and ERK2 pathway by was blocked only by AG1478 . Positive_regulation EPHB2 MBTPS1 15975516 1424441 Both and SEW2871 *activated* [ERK] , Akt , and Rac signaling pathways and induced S1P(1) internalization and recycling , unlike FTY720-phosphate , which induces receptor degradation . Positive_regulation EPHB2 MBTPS1 16931773 1633002 Moreover , MMP- and ROCK dependent molecular events are implicated in the regulation of the *induced* activation of [ERK] . Positive_regulation EPHB2 MBTPS1 18296752 1896711 *activates* Akt and [ERK] in adult mouse ventricular myocytes through a pertussis toxin-sensitive ( G ( i/o ) -mediated ) pathway . Positive_regulation EPHB2 MBTPS1 18296752 1896715 Akt and [ERK] *activation* by are reduced approximately 30 % in S1P(3) and 60 % in S1P(2) receptor knock-out myocytes . Positive_regulation EPHB2 MBTPS1 18296752 1896716 *mediated* activation of [ERK] or Akt was not diminished but inhibition of cAMP accumulation by S1P and SEW2871 was abolished by MbetaCD treatment . Positive_regulation EPHB2 MBTPS1 19077254 2003173 LPA and also *induce* p44/42 [ERK] MAP kinase phosphorylation in these cells and stimulate cell proliferation via G i/o coupled receptors in an Epidermal Growth Factor Receptor (EGFR)- and ERK dependent pathway . Positive_regulation EPHB2 MBTPS1 19208746 2039237 Both LPA and *activated* PI3K , [Ras/ERK] , and Rho/Rho kinase pathways , leading to migration , G ( 1 ) -S cell cycle progression , and stress fiber formation , respectively . Positive_regulation EPHB2 MBTPS1 19208746 2039243 Although LPA and *activated* both PI3K/Akt and [Ras/ERK] signaling through G ( i ) , anastellin inhibited only the Ras/ERK pathway . Positive_regulation EPHB2 MBTPS1 19433984 2096500 A selective S1P3 receptor antagonist ( CAY10444 ) had no effect on *induced* [ERK] activation . Positive_regulation EPHB2 MBTPS1 19433984 2096504 Thus , exogenous *induces* rapid and reversible S1P1 mediated [ERK] phosphorylation . Positive_regulation EPHB2 MBTPS1 20008963 2217586 Further study revealed that both MDG-1 and *induce* Akt and [ERK] phosphorylation in a dose- and time dependent manner , an effect that is attenuated by pre-treatment with either the Akt inhibitor wortmannin or the ERK inhibitor PD98059 , and MDG-1 can also induce eNOS phosphorylation and increases in production of NO . Positive_regulation EPHB2 MBTPS1 21749389 2452455 The results showed that pertussis toxin completely abolished the hypopigmentary effects and [ERK] pathway *activation* by , suggesting that S1P regulated melanogenesis via its receptor . Positive_regulation EPHB2 MBTPS1 21749389 2452456 The use of specific receptor antagonists indicated that the S1P(3) receptor was dominantly involved in *induced* [ERK] activation and hypopigmentation . Positive_regulation EPHB2 MBTPS1 21876704 2473906 Furthermore , promotes cardiogenesis and similarly *activates* [Erk] signalling in mouse ES cells . Positive_regulation EPHB2 MBTPS1 23192342 2730327 *stimulated* cell migration and activation of Akt , [ERK] , and Rac1 , the latter of which acts as a signaling molecule essential for cell migration and tube formation , via S1P(1) in ECs . Positive_regulation EPHB2 MBTPS1 23426175 2760036 Exogenous stimulation with *increased* [ERK] phosphorylation and CD44 protein expression in HCT116 cells , but treatment with an MEK inhibitor and S1P2 receptor antagonist blocked this effect . Positive_regulation EPHB2 MBTPS1 9882706 584339 On the other hand , the *induced* [ERK] activation was hardly affected by ethanol , which switched the product of phospholipase D from phosphatidic acid to metabolism-resistant phosphatidylethanol . Positive_regulation EPHB2 MBTPS1 9882706 584341 This indicates that intracellular increase in is not *necessary* for the S1P induced [ERK] activation , and hence suggests the extracellular action mechanism of S1P . Positive_regulation EPHB2 MC1R 23000456 2694279 In human melanocytes , [ERK] *activation* by relies on cAMP independent transactivation of the c-KIT receptor . Positive_regulation EPHB2 MC1R 23000456 2694280 High cAMP levels were compatible with normal ERK activation but , surprisingly , the adenylyl cyclase activator forskolin abolished [ERK] *activation* by , most likely by a cAMP independent mechanism . Positive_regulation EPHB2 MCTS1 19789340 2147768 Our findings establish a functional molecular interaction between MCT-1 and the MEK/ERK signaling pathway and suggest that the *activation* of function by its upstream kinase [ERK] plays an important role in lymphomagenesis . Positive_regulation EPHB2 MET 12791506 1097691 deprivation *inhibits* phosphorylation but not protein expression of FAK and [ERK] in PC3 . Positive_regulation EPHB2 MET 14684163 1189905 A novel MET interacting protein shares high sequence similarity with RanBPM , but fails to stimulate *induced* [Ras/Erk] signaling . Positive_regulation EPHB2 MET 20683950 2299068 In HCC cell lines , Spry2 overexpression inhibits *induced* cell proliferation as well as [ERK] and AKT activation , whereas loss of Spry2 potentiates c-Met signaling . Positive_regulation EPHB2 MET 23318428 2860724 Expression of with Tyr542/580Phe mutations *resulted* in the suppression of [Erk] activation . Positive_regulation EPHB2 MGAT3 11134020 794914 These results suggest that overexpression in HeLaS3 cells *resulted* in an enhancement of EGF induced [ERK] phosphorylation at least in part by the up-regulation of the endocytosis of EGFR . Positive_regulation EPHB2 MGLL 23744646 2819990 In addition , signaling *promoted* phosphorylation of the MAPK [ERK] and the transcription factor CREB . Positive_regulation EPHB2 MGP 17407158 1797782 However , phorbol 12-myristate 13-acetate ( PMA ) , a selective PKC activator *induced* mRNA expression through activation of extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 MIF 16122907 1507320 A role for an upstream Src kinase was proven by applying Src-deficient cells which did not exhibit transient ERK activation upon treatment with MIF , but in which *induced* [ERK] signalling could be restored by re-expressing Src . Positive_regulation EPHB2 MIF 16122907 1507321 Intriguingly , JAB1/CSN5 , a signalosome component , cellular binding protein of MIF and regulator of cell proliferation and survival , had a marked , yet dual , effect on *induced* [ERK] signalling . Positive_regulation EPHB2 MIF 16122907 1507324 By contrast , JAB1-knock-down by siRNA revealed that minimum JAB1 levels were necessary for transient *activation* of [ERK] by . Positive_regulation EPHB2 MIF 18821572 1993592 To understand the *role* of secretion in thrombin induced biphasic activation of [ERK] ( 1/2 ) , BPAE cells were treated with ( i ) recombinant MIF , and ( ii ) the medium collected from thrombin treated BPAE cells . Positive_regulation EPHB2 MIF 18821572 1993594 Inhibition of secretion by MIF siRNA or antisense-MIF treatment , along with a neutralizing antibody , *attenuated* the thrombin induced second phase [ERK] phosphorylation , suggesting a direct involvement of MIF in the second phase of ERK ( 1/2 ) activation . Positive_regulation EPHB2 MIF 23252627 2737266 These changes were associated with up-regulation of and its receptor CD74 *activation* of [ERK] ( extracellular-signal regulated kinase ) and NF-?B ( nuclear factor ?B ) signalling , prominent macrophage and T-cell infiltration , as well as up-regulation of Th1 [ T-bet and IFN? ( interferon ? ) ] and Th17 [ STAT3 ( signal transducer and activator of transcription 3 ) and IL ( interleukin)-17A ] as well as IL-1ß and TNFa ( tumour necrosis factor a ) . Positive_regulation EPHB2 MIP 15145928 1267556 Lens major intrinsic protein <(MIP)/aquaporin 0> expression in rat lens epithelia explants *requires* fibroblast growth factor induced [ERK] and JNK signaling . Positive_regulation EPHB2 MIPEP 15145928 1267557 Lens 0 expression in rat lens epithelia explants *requires* fibroblast growth factor induced [ERK] and JNK signaling . Positive_regulation EPHB2 MIR20A 22648654 2638350 Hypoxia induced expression *increases* [ERK] phosphorylation and angiogenic gene expression in endometriotic stromal cells . Positive_regulation EPHB2 MIR29A 23529662 2787950 *regulated* the abundance of Wnt signaling components ( Wnt-3a , glycogen synthase kinase 3ß , and ß-catenin ) , the Wnt inhibitor Dkk-1 , Akt , and phosphorylated [ERK] , and the expression of the osteogenic factors RUNX-2 and insulin-like growth factor 1 in bone tissue . Positive_regulation EPHB2 MITF 23443487 2749207 Blocking of the activity of Nox with diphenylene iodonium inhibited ROS production , *activation* of extracellular signal regulated kinase ( [ERK] ) , and the expression of RANK , PU.1 and . Positive_regulation EPHB2 MLST8 20512842 2270565 In this report , we focused on studying the *role* of mTORC1 and in rapamycin mediated Akt and [ERK] phosphorylation , and the antitumor effect of rapamycin in cancer cells in combination with Akt and ERK inhibitors . Positive_regulation EPHB2 MMP1 14634122 1170909 Our data indicate that : 1 ) [ERK] activation *mediates* MMP-1 but not MMP-13 release from FLSCs , 2 ) COX-2 derived E PGs inhibit MMP-1 release from FLSCs via inhibition of ERK , and 3 ) COX inhibitors , by attenuating PGE inhibition of ERK , enhance the release of by FLSC . Positive_regulation EPHB2 MMP1 15210577 1268080 6MNA ( 50-150 microm ) stimulated ( approximately 200 % ) and nabumetone ( 150 microm ) inhibited ( approximately 50 % ) matrix metalloproteinase (MMP)-1 , but not MMP-13 secretion from SFs. 3 6MNA stimulation of MMP-1 secretion was inhibited approximately 30 % by PGE1 ( 1 microm ) and approximately 80 % by the Erk pathway inhibitor UO126 ( 10 microm ) , confirming that PGE depletion and [Erk] *activation* mediate secretion by 6MNA. 4 Consistent with its role as an Erk inhibitor , nabumetone ( 150 microm ) abrogated 6MNA enhancement of MMP-1 secretion. 5 UO126 ( 10 microm ) and nabumetone ( 150 microm ) inhibited ( approximately 70 and 40 % , respectively ) , but 6MNA ( 150 microm ) enhanced ( approximately 40 % ) , NF-kappaB activation. 6 Our data indicate that 6MNA shares with other COX inhibitors several proinflammatory effects on synovial fibroblasts . Positive_regulation EPHB2 MMP1 15640153 1381316 secretion *required* activation of the MAPK [Erk] and subsequent protein synthesis but was down-regulated by the alternate MAPK , p38 . Positive_regulation EPHB2 MMP1 18713744 1974764 This study provides the first evidence that *mediated* cleavage of [EphB2] is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses . Positive_regulation EPHB2 MMP1 20102637 2213037 Chondrosarcoma cell invasion is increased by hypoxia induced expression of CXCR4 and and is *mediated* by HIF-1a and [ERK] . Positive_regulation EPHB2 MMP1 24012928 2862329 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an inhibitor , or PD98059 ( 50 µM ) , an [ERK] *inhibitor* , also suppressed it . Positive_regulation EPHB2 MMP10 18713744 1974765 This study provides the first evidence that *mediated* cleavage of [EphB2] is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses . Positive_regulation EPHB2 MMP10 24012928 2862330 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an inhibitor , or PD98059 ( 50 µM ) , an [ERK] *inhibitor* , also suppressed it . Positive_regulation EPHB2 MMP11 18713744 1974766 This study provides the first evidence that *mediated* cleavage of [EphB2] is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses . Positive_regulation EPHB2 MMP11 24012928 2862331 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an inhibitor , or PD98059 ( 50 µM ) , an [ERK] *inhibitor* , also suppressed it . Positive_regulation EPHB2 MMP12 18713744 1974767 This study provides the first evidence that *mediated* cleavage of [EphB2] is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses . Positive_regulation EPHB2 MMP12 24012928 2862332 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an inhibitor , or PD98059 ( 50 µM ) , an [ERK] *inhibitor* , also suppressed it . Positive_regulation EPHB2 MMP13 18713744 1974768 This study provides the first evidence that *mediated* cleavage of [EphB2] is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses . Positive_regulation EPHB2 MMP13 24012928 2862333 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an inhibitor , or PD98059 ( 50 µM ) , an [ERK] *inhibitor* , also suppressed it . Positive_regulation EPHB2 MMP14 11684104 875739 Accordingly , overexpression *induced* the activation of [ERK] , this process being also dependent on the presence of its cytoplasmic domain . Positive_regulation EPHB2 MMP14 11684104 875741 *induced* activation of both migration and [ERK] required the catalytic activity of the enzyme as well as attachment of the cells to matrix proteins . Positive_regulation EPHB2 MMP14 11684104 875742 The *dependent* activation of [ERK] was correlated with the activation of transcription through the serum response element , whereas other promoters were unaffected . Positive_regulation EPHB2 MMP14 14871836 1208307 In addition , expression of the hemopexin-like domain of MT1-MMP in HT1080 cells interfered with MMP-2 processing , ERK activation , and cell migration , implying that the enzymatic activity of is *involved* in collagen induced [ERK] activation , which results in enhanced cell migration . Positive_regulation EPHB2 MMP14 14871836 1208309 Thus , adhesion of HT1080 cells to type I collagen induces *dependent* [ERK] activation , which in turn causes an increase in MT1-MMP levels and subsequent cell migration . Positive_regulation EPHB2 MMP14 18713744 1974769 This study provides the first evidence that *mediated* cleavage of [EphB2] is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses . Positive_regulation EPHB2 MMP14 22002060 2516449 Intracellular trafficking of MT1-MMP was observed to be coupled to the trafficking of integrin a5 and phosphorylation of [ERK] that coincided with this was *dependent* on phosphorylation of . Positive_regulation EPHB2 MMP14 24012928 2862334 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an inhibitor , or PD98059 ( 50 µM ) , an [ERK] *inhibitor* , also suppressed it . Positive_regulation EPHB2 MMP15 18713744 1974770 This study provides the first evidence that *mediated* cleavage of [EphB2] is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses . Positive_regulation EPHB2 MMP15 24012928 2862335 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an inhibitor , or PD98059 ( 50 µM ) , an [ERK] *inhibitor* , also suppressed it . Positive_regulation EPHB2 MMP16 18713744 1974771 This study provides the first evidence that *mediated* cleavage of [EphB2] is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses . Positive_regulation EPHB2 MMP16 24012928 2862336 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an inhibitor , or PD98059 ( 50 µM ) , an [ERK] *inhibitor* , also suppressed it . Positive_regulation EPHB2 MMP17 18713744 1974772 This study provides the first evidence that *mediated* cleavage of [EphB2] is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses . Positive_regulation EPHB2 MMP17 24012928 2862337 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an inhibitor , or PD98059 ( 50 µM ) , an [ERK] *inhibitor* , also suppressed it . Positive_regulation EPHB2 MMP19 18713744 1974773 This study provides the first evidence that *mediated* cleavage of [EphB2] is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses . Positive_regulation EPHB2 MMP19 24012928 2862338 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an inhibitor , or PD98059 ( 50 µM ) , an [ERK] *inhibitor* , also suppressed it . Positive_regulation EPHB2 MMP2 17597617 1764996 activation by the PPARgamma agonist , ciglitazone , *induces* cell invasion through the generation of ROS and the activation of [ERK] . Positive_regulation EPHB2 MMP2 17597617 1764999 This study suggests that ciglitazone induced activation *increases* PPARgamma independent tumor cell invasion through ROS production and [ERK] activation in some types of cancer cells . Positive_regulation EPHB2 MMP2 18559520 1924014 Overexpression of constitutively active AKT reversed the *mediated* inhibition of tube formation and induction of [ERK] phosphorylation . Positive_regulation EPHB2 MMP2 18713744 1974774 This study provides the first evidence that *mediated* cleavage of [EphB2] is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses . Positive_regulation EPHB2 MMP2 23966323 2850444 Anti-TG2 antibodies impaired angiogenesis by inhibiting the activation of , disarranging cytoskeleton fibers , changing the physical and mechanical properties of cell membranes , and *inhibiting* the intracellular phosphorylation of FAK and [ERK] . Positive_regulation EPHB2 MMP2 24012928 2862339 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an inhibitor , or PD98059 ( 50 µM ) , an [ERK] *inhibitor* , also suppressed it . Positive_regulation EPHB2 MMP20 18713744 1974775 This study provides the first evidence that *mediated* cleavage of [EphB2] is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses . Positive_regulation EPHB2 MMP20 24012928 2862340 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an inhibitor , or PD98059 ( 50 µM ) , an [ERK] *inhibitor* , also suppressed it . Positive_regulation EPHB2 MMP21 18713744 1974762 This study provides the first evidence that *mediated* cleavage of [EphB2] is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses . Positive_regulation EPHB2 MMP21 24012928 2862327 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an inhibitor , or PD98059 ( 50 µM ) , an [ERK] *inhibitor* , also suppressed it . Positive_regulation EPHB2 MMP24 18713744 1974776 This study provides the first evidence that *mediated* cleavage of [EphB2] is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses . Positive_regulation EPHB2 MMP24 24012928 2862341 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an inhibitor , or PD98059 ( 50 µM ) , an [ERK] *inhibitor* , also suppressed it . Positive_regulation EPHB2 MMP25 18713744 1974759 This study provides the first evidence that *mediated* cleavage of [EphB2] is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses . Positive_regulation EPHB2 MMP25 24012928 2862324 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an inhibitor , or PD98059 ( 50 µM ) , an [ERK] *inhibitor* , also suppressed it . Positive_regulation EPHB2 MMP26 18713744 1974760 This study provides the first evidence that *mediated* cleavage of [EphB2] is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses . Positive_regulation EPHB2 MMP26 24012928 2862325 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an inhibitor , or PD98059 ( 50 µM ) , an [ERK] *inhibitor* , also suppressed it . Positive_regulation EPHB2 MMP27 18713744 1974761 This study provides the first evidence that *mediated* cleavage of [EphB2] is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses . Positive_regulation EPHB2 MMP27 24012928 2862326 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an inhibitor , or PD98059 ( 50 µM ) , an [ERK] *inhibitor* , also suppressed it . Positive_regulation EPHB2 MMP28 18713744 1974763 This study provides the first evidence that *mediated* cleavage of [EphB2] is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses . Positive_regulation EPHB2 MMP28 24012928 2862328 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an inhibitor , or PD98059 ( 50 µM ) , an [ERK] *inhibitor* , also suppressed it . Positive_regulation EPHB2 MMP3 15389548 1304765 Like NFLC , induction of urokinase plasminogen activator (uPAR) , , Fra-1 and transforming growth factor beta 1 ( TGF beta 1 ) *required* collaborative [ERK] and JNK signaling while the increased expression of cortexin , rat collapsin response mediator protein 4 ( rCRMP4 ) , rat growth and transformation dependent protein ( RGT ) , and synapsin II required neither mitogen activated protein kinase (MAPK) pathway . Positive_regulation EPHB2 MMP3 18340449 1932013 Using chondrosarcoma cells stimulated with IL-1beta , the effects of GLN on the mRNA and protein levels of , the *activation* of JNK , [ERK] , p38 , NF-kappaB , and AP-1 , the nuclear translocation of NF-kappaB/Rel family members , and PI3-kinase/Akt activation were studied . Positive_regulation EPHB2 MMP3 18713744 1974777 This study provides the first evidence that *mediated* cleavage of [EphB2] is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses . Positive_regulation EPHB2 MMP3 24012928 2862342 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an inhibitor , or PD98059 ( 50 µM ) , an [ERK] *inhibitor* , also suppressed it . Positive_regulation EPHB2 MMP7 18713744 1974778 This study provides the first evidence that *mediated* cleavage of [EphB2] is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses . Positive_regulation EPHB2 MMP7 21999204 2547380 Mesothelin enhances invasion of ovarian cancer by *inducing* through [MAPK/ERK] and JNK pathways . Positive_regulation EPHB2 MMP7 24012928 2862343 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an inhibitor , or PD98059 ( 50 µM ) , an [ERK] *inhibitor* , also suppressed it . Positive_regulation EPHB2 MMP8 18713744 1974779 This study provides the first evidence that *mediated* cleavage of [EphB2] is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses . Positive_regulation EPHB2 MMP8 24012928 2862344 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an inhibitor , or PD98059 ( 50 µM ) , an [ERK] *inhibitor* , also suppressed it . Positive_regulation EPHB2 MMP9 11509539 848312 Stimulation of VSM cells with IL-1 beta significantly ( P < 0.05 ) increased superoxide production , [ERK] activation , and *induction* . Positive_regulation EPHB2 MMP9 11509539 848316 In addition , pretreatment of VSM cells with a specific ERK pathway inhibitor , PD-98059 , or DETA NONOate inhibited IL-1 beta stimulated [ERK] activation and *induction* . Positive_regulation EPHB2 MMP9 11509539 848320 Direct exposure of VSM cells to increased superoxide levels by treatment with xanthine/xanthine oxidase increased ERK activation and MMP-9 induction , whereas pretreatment of cells with PD-98059 significantly ( P < 0.05 ) inhibited xanthine/xanthine oxidase stimulated [ERK] activation and *induction* . Positive_regulation EPHB2 MMP9 11709424 879799 Role of reactive oxygen species in IL-1 beta stimulated sustained [ERK] activation and *induction* . Positive_regulation EPHB2 MMP9 17072348 1716598 Induction of by TGF-beta-ALK5 signaling *requires* [MEK-ERK] but not JNK , p38 MAPK or Smad4 . Positive_regulation EPHB2 MMP9 17991734 1851017 We found that the addition of beta1 blocking antibodies inhibited *induced* [ERK] activation . Positive_regulation EPHB2 MMP9 18713744 1974780 This study provides the first evidence that *mediated* cleavage of [EphB2] is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses . Positive_regulation EPHB2 MMP9 20568116 2320320 Macrophages under certain stimuli *induce* expression and protein secretion through the activation of [MAPK-ERK] and NF-?B signaling pathways . Positive_regulation EPHB2 MMP9 24012928 2862345 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an inhibitor , or PD98059 ( 50 µM ) , an [ERK] *inhibitor* , also suppressed it . Positive_regulation EPHB2 MMP9 24188385 2890260 Co-culture with CM resulted in an increased resistance to Adriamycin and enhanced expressions of a-FP , , ABCG2 , CD133 , and SOX2 , as well as the *activation* of [ERK] , AKT , WNT , and TGF-ß1 pathways . Positive_regulation EPHB2 MNAT1 11331872 808911 [ERK] *induces* , a neuron-specific activator of Cdk5 , through induction of Egr1 . Positive_regulation EPHB2 MOK 12962137 1138499 This culture condition also dose-dependently increased the expression of and the *activation* of [ERK] . Positive_regulation EPHB2 MOK 22496883 2583719 may *mediate* synergistically increased [ERK] activation and VSMC proliferation induced by mechanical stretching with and without AGEs . Positive_regulation EPHB2 MPL 12704121 1082309 Analysis of induced *activation* of the extracellular signal regulated kinase ( [ERK] ) and p38 mitogen activated protein ( MAP ) kinases revealed that MPL utilized both TLR2 and TLR4 for the phosphorylation of ERK1/2 , while TLR4 was the predominant receptor involved in the ability of MPL to phosphorylate p38 . Positive_regulation EPHB2 MPST 11641781 872174 specifically *activates* [ERK] but not JNK or p38 MAPK in transient transfected cells or in stable cell lines . Positive_regulation EPHB2 MPST 11641781 872191 Overexpression of dominant negative MEK1 or treatment with PD98059 abolishes *induced* [ERK] activity , whereas dominant negative Ras or c-Raf-1 mutants failed to do so , indicating MST4 activates MEK1/ERK via a Ras/Raf-1 independent pathway . Positive_regulation EPHB2 MPST 9182538 434619 Both MUK/DLK/ZPK and MST/MLK2 cause a slight activation of p38/Mpk2 when overexpressed in COS-1 cells , whereas , but not MUK/DLK/ZPK , *activates* [extracellular response kinase (ERK)] to a certain degree . Positive_regulation EPHB2 MPZ 12062470 953221 *increases* alpha-synuclein expression and [ERK/MAP-kinase] phosphorylation in human neuroblastoma SH-SY5Y cells . Positive_regulation EPHB2 MPZ 21781996 2500349 VEGF reversed the inhibition of phosphoinositide 3-kinase (PI3-K)/Akt pathway caused by MPP ( + ) , but further enhanced the activation of [ERK] *induced* by ( + ) . Positive_regulation EPHB2 MRAS 18977283 2015113 Exogenous expression of an activated in PC12 cells *caused* [ERK] activation and induced neuritogenesis via the ERK pathway as do mammalian M-Ras and Ras . Positive_regulation EPHB2 MRAS 22121046 2599603 Using constitutively active M-Ras ( Q71L ) containing additional mutations within its effector binding loop , we found that *induces* [MEK/ERK] dependent and -independent Elk1 activation as well as phosphatidylinositol 3 kinase (PI3K)/Akt and JNK/cJun activation in human MCF-7 breast cancer cells . Positive_regulation EPHB2 MRE11A 11146560 760891 We provide evidence that mutants *promote* [ERK] activation and that the active protein induces a more sustained activation than the inactive protein . Positive_regulation EPHB2 MRE11A 11228165 788436 is *involved* in cell stretching modulation of p38 but not [ERK] or JNK MAP kinase . Positive_regulation EPHB2 MRE11A 11479306 860643 Moreover , inhibition of by a Rap1 GTPase activating protein-1 also *resulted* in a decrease in [ERK] and Akt phosphorylation , which was not further decreased by cAMP , suggesting that cAMP inhibits ERK and Akt by inhibiting Rap1 . Positive_regulation EPHB2 MRE11A 11479306 860699 The *role* of in [ERK] and Akt activity was further demonstrated by our observation that an active form of Epac , which activated Rap1 in the absence of cAMP , increased ERK and Akt phosphorylation . Positive_regulation EPHB2 MRE11A 14551200 1175545 Experiments involving the expression of the dominant negative mutants of Ras and Rap1 signaling ( RasN17 or Rap1N17 ) indicate that both GTPases Ras and Rap1 are recruited for the ERK activation by VIP and PACAP38 , whereas is poorly *involved* in TRH or EGF induced [ERK] activation . Positive_regulation EPHB2 MRE11A 14607972 1162189 Functionally , either interferes with Ras mediated ERK activation or *activates* [ERK] independently of Ras in a cell-context dependent manner . Positive_regulation EPHB2 MRE11A 16507992 1529683 We confirm that the PKA independent activation of by Epac1 activates a perinuclear pool of Rap1 and that this does not *result* in [ERK] activation . Positive_regulation EPHB2 MRE11A 17472964 1750450 Moreover , Ca2+ induced *activation* of [ERK] through and expression of loricrin were reduced in primary cultured nectin-1-/- keratinocytes ; Positive_regulation EPHB2 MRXS5 23500014 2776927 Depletion of cell membrane by sodium chlorate *reduced* FSH- , but not cholera toxin stimulated cAMP production as well as basal [ERK] phosphorylation through an okadaic acid ( OA ) -sensitive mechanism . Positive_regulation EPHB2 MST1 12270548 990766 Tyrosine phosphorylation of ERK was detected after stimulation with IL-3 or MSP , whereas treatment with U0126 specifically inhibited IL-3- or *induced* [ERK] phosphorylation but not tyrosine phosphorylation of betac . Positive_regulation EPHB2 MST1 23583394 2783592 GM caused *induction* of [phospho-ERK] , phospho-JNK , and phospho-p38 . Positive_regulation EPHB2 MT2A 15961554 1440806 Prior administration of the MAPK kinase inhibitor U0126 abolished the capacity of MTII to suppress 2-h food intake and significantly decreased *induced* [ERK] phosphorylation in the NTS . Positive_regulation EPHB2 MT2A 23131177 2745288 Representative ligands also *induced* [ERK] phosphorylation in both recombinant and native cell lines , and no cross-reactivity to 17 other GPCRs could be detected . Positive_regulation EPHB2 MTA1 23683282 2785496 Furthermore , phosphorylation of [ERK] and JNK in *response* to was inhibited when the medium was supplemented with nifedipine . Positive_regulation EPHB2 MTA2 23683282 2785497 Furthermore , phosphorylation of [ERK] and JNK in *response* to was inhibited when the medium was supplemented with nifedipine . Positive_regulation EPHB2 MTA3 23683282 2785495 Furthermore , phosphorylation of [ERK] and JNK in *response* to was inhibited when the medium was supplemented with nifedipine . Positive_regulation EPHB2 MTOR 19303025 2073343 The inhibition of *blocked* CAPE induced [ERK] phosphorylation . Positive_regulation EPHB2 MTOR 20512842 2270568 In this report , we focused on studying the *role* of and mTORC2 in rapamycin mediated Akt and [ERK] phosphorylation , and the antitumor effect of rapamycin in cancer cells in combination with Akt and ERK inhibitors . Positive_regulation EPHB2 MTOR 20544018 2271771 Very recently , three studies have reported on the same protein under two other names : the human p27RF-Rho that regulates RhoA activation and actin dynamics , and its rodent orthologue p18 that controls both LE/LY dynamics through the [MERK-ERK] pathway and the lysosomal *activation* of complex 1 by amino acids . Positive_regulation EPHB2 MTOR 22960230 2684078 Our data suggest that dual inhibitors may represent a useful pharmacological tool in the therapy of advanced adrenocortical cancer and that simultaneous inhibition of both [Erk] and PI3K - mTOR pathways may be *required* to obtain a higher antiproliferative effect in this type of tumor . Positive_regulation EPHB2 MTOR 24597762 2933798 Exposure of CGNs to GDF15 markedly induced the phosphorylation of [ERK] ( extracellular-signal regulated kinase ) , Akt and mTOR ( mammalian target of rapamycin ) , but the GDF15 induced IK densities and increased expression of Kv2.1 were *attenuated* only by Akt and , and not ERK , inhibitors . Positive_regulation EPHB2 MTRR 11779205 900056 These results demonstrate that stimulation of the murine receptor *promotes* [ERK] activation via the alpha subunit of a pertussis toxin-sensitive protein in a Ras independent pathway . Positive_regulation EPHB2 MUC1 22457794 2578449 Suppression of expression resulted in EGFR destabilization and *inhibition* of the BPDE induced activation of Akt and [ERK] and increase of cytotoxicity . Positive_regulation EPHB2 MUC1 24043631 2857346 In studies of breast cancer cells stably silenced for MUC1 or overexpressing the oncogenic MUC1-C subunit , we demonstrate that is *sufficient* for induction of MEK ? [ERK] signaling and that treatment with a MUC1-C inhibitor suppresses ERK activation . Positive_regulation EPHB2 MUC13 22027689 2533790 Conversely , suppression of in HPAFII pancreatic cancer cells by short hairpin RNA *resulted* in suppression of tumorigenic characteristics , repression of HER2 , PAK1 , [ERK] , and S100A4 , and upregulation of p53 . Positive_regulation EPHB2 MUC5AC 22441738 2658250 Moreover , the 12R-LOX product 12 ( R ) -hydroxyeicosatetraenoic acid , *induces* expression , [ERK] activation and Sp1 translocation . Positive_regulation EPHB2 MYD88 20473309 2269506 ( myeloid differentiation primary response gene 88 ) -independent activation of ERK by epidermal growth factor (EGF) *increased* [p-ERK] and c-Myc and restored the multiple intestinal neoplasia ( Min ) phenotype in Apc ( min/+ ) /Myd88 ( -/- ) mice . Positive_regulation EPHB2 MYD88 21881005 2510431 Basolateral LPS inhibits NHE3 and HCOFormula absorption through dependent [ERK] *activation* in medullary thick ascending limb . Positive_regulation EPHB2 MYD88 22523073 2608017 These results indicate that the effect of basolateral LPS to inhibit HCO ( 3 ) ( - ) absorption in the MTAL through *dependent* [ERK] activation depends on a novel interaction between TLR4 and TLR2 . Positive_regulation EPHB2 MYD88 22634720 2675863 Furthermore , we demonstrated that dependent [p38/ERK] *activation* is critical to TLR2 mediated T-cell IFN-? release following EtOH and burn injury . Positive_regulation EPHB2 MYF5 17481856 1761497 Control of activation in adult skeletal myonuclei *requires* [ERK] signalling . Positive_regulation EPHB2 MYH1 9849961 554166 Furthermore , inhibition of PI 3-kinase activity with LY294002 blocks differentiation , as demonstrated by inhibition of myogenin and expression and [ERK] *activation* . Positive_regulation EPHB2 MYH10 9849961 554167 Furthermore , inhibition of PI 3-kinase activity with LY294002 blocks differentiation , as demonstrated by inhibition of myogenin and expression and [ERK] *activation* . Positive_regulation EPHB2 MYH11 9849961 554168 Furthermore , inhibition of PI 3-kinase activity with LY294002 blocks differentiation , as demonstrated by inhibition of myogenin and expression and [ERK] *activation* . Positive_regulation EPHB2 MYH13 9849961 554169 Furthermore , inhibition of PI 3-kinase activity with LY294002 blocks differentiation , as demonstrated by inhibition of myogenin and expression and [ERK] *activation* . Positive_regulation EPHB2 MYH14 9849961 554163 Furthermore , inhibition of PI 3-kinase activity with LY294002 blocks differentiation , as demonstrated by inhibition of myogenin and expression and [ERK] *activation* . Positive_regulation EPHB2 MYH15 9849961 554165 Furthermore , inhibition of PI 3-kinase activity with LY294002 blocks differentiation , as demonstrated by inhibition of myogenin and expression and [ERK] *activation* . Positive_regulation EPHB2 MYH16 9849961 554164 Furthermore , inhibition of PI 3-kinase activity with LY294002 blocks differentiation , as demonstrated by inhibition of myogenin and expression and [ERK] *activation* . Positive_regulation EPHB2 MYH2 9849961 554170 Furthermore , inhibition of PI 3-kinase activity with LY294002 blocks differentiation , as demonstrated by inhibition of myogenin and expression and [ERK] *activation* . Positive_regulation EPHB2 MYH3 9849961 554171 Furthermore , inhibition of PI 3-kinase activity with LY294002 blocks differentiation , as demonstrated by inhibition of myogenin and expression and [ERK] *activation* . Positive_regulation EPHB2 MYH4 9849961 554172 Furthermore , inhibition of PI 3-kinase activity with LY294002 blocks differentiation , as demonstrated by inhibition of myogenin and expression and [ERK] *activation* . Positive_regulation EPHB2 MYH6 9849961 554173 Furthermore , inhibition of PI 3-kinase activity with LY294002 blocks differentiation , as demonstrated by inhibition of myogenin and expression and [ERK] *activation* . Positive_regulation EPHB2 MYH7 9849961 554174 Furthermore , inhibition of PI 3-kinase activity with LY294002 blocks differentiation , as demonstrated by inhibition of myogenin and expression and [ERK] *activation* . Positive_regulation EPHB2 MYH8 9849961 554175 Furthermore , inhibition of PI 3-kinase activity with LY294002 blocks differentiation , as demonstrated by inhibition of myogenin and expression and [ERK] *activation* . Positive_regulation EPHB2 MYH9 9849961 554176 Furthermore , inhibition of PI 3-kinase activity with LY294002 blocks differentiation , as demonstrated by inhibition of myogenin and expression and [ERK] *activation* . Positive_regulation EPHB2 MYL1 19179620 2049203 activation by strain *required* FAK , Rac1 , PI3K , AKT , GSK , and [ERK] but not Src or p38 . Positive_regulation EPHB2 MYL10 19179620 2049202 activation by strain *required* FAK , Rac1 , PI3K , AKT , GSK , and [ERK] but not Src or p38 . Positive_regulation EPHB2 MYL2 15962288 1434564 Inhibition of or myosin light chain kinase *caused* a complete loss of [ERK] phosphorylation in a time- and dose dependent manner , but proved dispensable for activation of the PI3K pathway . Positive_regulation EPHB2 MYL2 19179620 2049204 activation by strain *required* FAK , Rac1 , PI3K , AKT , GSK , and [ERK] but not Src or p38 . Positive_regulation EPHB2 MYL3 19179620 2049205 activation by strain *required* FAK , Rac1 , PI3K , AKT , GSK , and [ERK] but not Src or p38 . Positive_regulation EPHB2 MYL4 19179620 2049206 activation by strain *required* FAK , Rac1 , PI3K , AKT , GSK , and [ERK] but not Src or p38 . Positive_regulation EPHB2 MYL5 19179620 2049207 activation by strain *required* FAK , Rac1 , PI3K , AKT , GSK , and [ERK] but not Src or p38 . Positive_regulation EPHB2 MYL6 19179620 2049208 activation by strain *required* FAK , Rac1 , PI3K , AKT , GSK , and [ERK] but not Src or p38 . Positive_regulation EPHB2 MYL7 19179620 2049201 activation by strain *required* FAK , Rac1 , PI3K , AKT , GSK , and [ERK] but not Src or p38 . Positive_regulation EPHB2 MYL9 19179620 2049200 activation by strain *required* FAK , Rac1 , PI3K , AKT , GSK , and [ERK] but not Src or p38 . Positive_regulation EPHB2 MYLIP 19043405 2001606 In vivo silencing of by a specific antagomir in a mouse pressure-overload induced disease model *reduces* cardiac [ERK-MAP] kinase activity , inhibits interstitial fibrosis and attenuates cardiac dysfunction . Positive_regulation EPHB2 MYLIP 20299489 2260023 Cell signaling analysis showed that the activation of extracellular signal regulated protein kinase ( [ERK] ) in response to PMA strongly *induced* expression by transactivation via the activator protein-1 binding site in the upstream region of the miR-34a gene . Positive_regulation EPHB2 MYLIP 21544242 2424329 AKT and [extracellular regulated kinases (ERK)] 1/2 are *activated* by . Positive_regulation EPHB2 MYLIP 21668589 2446328 Overexpression of *suppressed* Spred1 expression and enhanced [ERK] activity in primary bone marrow cells and MC9 mast cells , which were associated with elevated FceRI mediated cytokine production . Positive_regulation EPHB2 MYLIP 23469214 2750327 Down-regulation of and up-regulations of Pdcd44 or Spry1 *blocked* the arsenite induced activations of JNK/c-Jun or [ERK/NF-?B] , indicating that knockdown of miR-21 inhibits feedback of ERK activation and JNK activation via increases of Pdcd4 and Spry1 protein levels , respectively . Positive_regulation EPHB2 MYLIP 23835497 2854254 Luciferase reporter assays confirmed that binds and *regulates* EphB1 and [EphB2] mRNAs . Positive_regulation EPHB2 MYLIP 24009080 2851434 Ectopic *resulted* in a decrease in [Erk] signaling and transformation , which was dependent on the down-regulation of c-Kit expression . Positive_regulation EPHB2 MYLIP 24803541 2950601 [EphB2] contributes to human naive B-cell activation and is *regulated* by . Positive_regulation EPHB2 MYLIP 24803541 2950603 Our study first suggested that [EphB2] was involved in human naive B cell activation through Src-p65 and Notch1 signaling pathways and could be *regulated* by . Positive_regulation EPHB2 MYLK 12773570 1095228 Inhibition of either or Rho kinase *blocked* sustained [ERK] signaling , but only Rho kinase inhibition allowed for the induction of cyclin D1 and activation of cdk4 via Rac/Cdc42 . Positive_regulation EPHB2 MYLK 15962288 1434565 Inhibition of myosin II or *caused* a complete loss of [ERK] phosphorylation in a time- and dose dependent manner , but proved dispensable for activation of the PI3K pathway . Positive_regulation EPHB2 MYOG 18508909 1945168 These findings suggest that MURC is involved in the skeletal myogenesis that results from modulation of expression and [ERK] *activation* . Positive_regulation EPHB2 MYOG 9849961 554177 Furthermore , inhibition of PI 3-kinase activity with LY294002 blocks differentiation , as demonstrated by inhibition of and myosin heavy chain expression and [ERK] *activation* . Positive_regulation EPHB2 NA 14588145 1159788 Also , prevented H ( 2 ) O ( 2 ) - and diamide *induced* p38 MAPK , but not [ERK] activation . Positive_regulation EPHB2 NA 16166589 1499843 Adaphostin/MG-132 lethality as well as mitochondrial damage , down-regulation of [Raf/MEK/ERK] , and activation of JNK were *attenuated* by the free-radical scavenger , suggesting that oxidative damage plays a functional role in antileukemic effects . Positive_regulation EPHB2 NA 16983658 1633648 Farnesyltransferase and MEK inhibitors completely abolished NAC induced p38 phosphorylation whereas p38 inhibitor did not influence *induced* [ERK] phosphorylation . Positive_regulation EPHB2 NA 18941206 1978142 *blocked* the activation of JNK and down-regulation of [ERK] , but both z-VAD-fmk ( N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone ) and ZB4 did not inhibit JNK activation of B7-H1 stimulation . Positive_regulation EPHB2 NA 20179891 2215938 Furthermore , *increased* the protein expression of [p-ERK] , while inhibited protein expression of p-JNK , NF-kappaB in gastric mucosa . Positive_regulation EPHB2 NA 21453688 2448137 *Activation* of [ERK] and JNK , but not p38 , via phosphorylation induction was identified in EPO1- but not EPO- or EPO2 treated U87 and C6 cells , and this was blocked by adding . Positive_regulation EPHB2 NA 22442667 2573523 In glial C6 cells , *promoted* phosphorylation of [ERK] induced by ( s ) -3,5-dihydroxy-phenylglycine ( DHPG ) , an agonist of group I mGlus . Positive_regulation EPHB2 NAALADL1 20652827 2447315 Data of Western blot revealed that poly *induced* [p-ERK] , p-JNK , and pp38 expression , but not pp65 , were suppressed by procaterol . Positive_regulation EPHB2 NAMPT 19906834 2203535 Both and nicotinamide mononucleotide *induced* activation of both insulin receptor and extracellular signal regulated kinase ( [ERK] ) 1/2 , with visfatin induced insulin receptor/ERK1/2 activation being inhibited by FK866 . Positive_regulation EPHB2 NCAM1 16469417 1554752 However , after induction of neuronal differentiation by retinoic acid the previously ineffective signals *activated* extracellular signal regulated kinase ( [ERK] ) and promoted neuritogenesis . Positive_regulation EPHB2 NCAM2 16469417 1554753 However , after induction of neuronal differentiation by retinoic acid the previously ineffective signals *activated* extracellular signal regulated kinase ( [ERK] ) and promoted neuritogenesis . Positive_regulation EPHB2 NCF1 12006386 940093 The overexpression of dominant negative in A10 cells *suppressed* lysoPC induced [ERK] activation . Positive_regulation EPHB2 NCK1 24670066 2930809 We found that down-regulation of *impaired* TCR induced phosphorylation of the kinases [Erk] and MEK , activation of the AP-1 and NFAT transcription factors and subsequently , IL-2 and CD69 expression . Positive_regulation EPHB2 NDFIP1 23851689 2825151 Ndfip1 and IL-2 have a similar expression pattern , and , following TCR stimulation , expression of both and IL-2 *requires* the activity of NFAT and [Erk] . Positive_regulation EPHB2 NDOR1 22076064 2534201 Together , these data suggest that dopamine D1 and D3 receptors differentially regulate the cocaine induced structural remodeling of dendrites and spines via mechanisms involving the consecutive actions of phosphorylation , [ERK] *activation* , and MEF2 activity in the NAc and CPu . Positive_regulation EPHB2 NDRG4 16408304 1540234 *enhances* NGF induced [ERK] activation uncoupled with Elk-1 activation . Positive_regulation EPHB2 NEDD9 16394015 1506057 Activation of [ERK] *requires* both and the MAPK kinase kinase , Tpl-2 . Positive_regulation EPHB2 NEDD9 16980301 1640381 Taken together , these results suggest that phosphorylation by GRK5 and binding of arrestin-2 negatively *regulates* LPS stimulated [ERK] activation . Positive_regulation EPHB2 NEDD9 22733995 2639207 *Activation* of [TPL-2/ERK] signaling by IKK induced proteolysis , therefore , induced a negative feedback loop to downregulate NF-?B dependent expression of the proinflammatory cytokine interleukin-12 (IL-12) . Positive_regulation EPHB2 NELFCD 20735431 2324065 Moreover , upregulation of in MDA-MB-231 cells *resulted* in the decrease of cyclin D1 , ß-catenin , and [ERK] activity , and the increase of p21 . Positive_regulation EPHB2 NEU3 16241905 1525600 When triggered by laminins , clearly *stimulated* phosphorylation of FAK ( focal adhesion kinase ) and [ERK] ( extracellular-signal regulated kinase ) , whereas there was no activation on fibronectin . Positive_regulation EPHB2 NEUROD1 18171671 1869738 Basic fibroblast growth factor induced of mouse bone marrow stromal cells *requires* FGFR-1 , [MAPK/ERK] , and transcription factor AP-1 . Positive_regulation EPHB2 NEUROD1 9525930 495535 Induction of of the rat pheochromocytoma cell line , PC12 cells , by nerve growth factor (NGF) *requires* activation of the mitogen activated protein (MAP) kinase or extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 NEUROD2 18171671 1869739 Basic fibroblast growth factor induced of mouse bone marrow stromal cells *requires* FGFR-1 , [MAPK/ERK] , and transcription factor AP-1 . Positive_regulation EPHB2 NEUROD2 9525930 495536 Induction of of the rat pheochromocytoma cell line , PC12 cells , by nerve growth factor (NGF) *requires* activation of the mitogen activated protein (MAP) kinase or extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 NEUROD4 18171671 1869736 Basic fibroblast growth factor induced of mouse bone marrow stromal cells *requires* FGFR-1 , [MAPK/ERK] , and transcription factor AP-1 . Positive_regulation EPHB2 NEUROD4 9525930 495533 Induction of of the rat pheochromocytoma cell line , PC12 cells , by nerve growth factor (NGF) *requires* activation of the mitogen activated protein (MAP) kinase or extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 NEUROD6 18171671 1869737 Basic fibroblast growth factor induced of mouse bone marrow stromal cells *requires* FGFR-1 , [MAPK/ERK] , and transcription factor AP-1 . Positive_regulation EPHB2 NEUROD6 9525930 495534 Induction of of the rat pheochromocytoma cell line , PC12 cells , by nerve growth factor (NGF) *requires* activation of the mitogen activated protein (MAP) kinase or extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 NFE2L2 19447102 2090723 These results suggest that lindenenyl acetate increases cellular resistance to glutamate induced oxidative injury in mouse hippocampal HT22 cells , presumably through the [ERK] *dependent* HO-1 expression . Positive_regulation EPHB2 NFE2L2 20806931 2352137 Inhibition of *activating* upstream kinase [MEK/ERK] by PD98059 weakened DEM mediated induction of CBR3 mRNA . Positive_regulation EPHB2 NFE2L2 21270272 2380791 Upregulation of by its activator , Dh404 , in cardiomyocytes in vitro and in vivo prevented hydrogen peroxide- and diabetes *induced* [ERK] activation and insulin signaling downregulation . Positive_regulation EPHB2 NFIC 19755487 2186611 Identification of a region in the human IRS2 promoter essential for stress induced transcription depending on SP1 , binding and [ERK] *activation* in HepG2 cells . Positive_regulation EPHB2 NFIC 21147777 2396212 Indeed , expression *promotes* [p53-ERK] interaction , which is diminished upon deletion of residues 859-884 . Positive_regulation EPHB2 NFKB1 11371570 834864 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and [ERK] and *activation* of cAMP-responsive element binding protein ( CREB ) , , and E2F ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation EPHB2 NFKB1 11447019 835453 Although ob/ob livers have significant histological liver injury and 11-fold greater serum alanine aminotransferase values than those of lean mice by 6 h post-LPS , they exhibit greater activation of AKT and [Erk] , more profound reductions in inhibitor kappa-B , enhanced *activation* of , and greater induction of NF-kappaB regulated genes . Positive_regulation EPHB2 NFKB1 12208854 998085 Granulocyte/macrophage-colony stimulating factor ( GM-CSF ) regulates lung innate immunity to lipopolysaccharide through [Akt/Erk] *activation* of and AP-1 in vivo . Positive_regulation EPHB2 NFKB1 12426209 1014365 Treatment of VSMCs with PDGF or EGF alone potently induced [ERK] phosphorylation and DNA synthesis but did not *induce* activation or iNOS expression . Positive_regulation EPHB2 NFKB1 15485634 1320645 CD40- and BAFF mediated survival is significantly increased in Act1-deficent B cells , with stronger IkappaB phosphorylation , processing of ( p100/p52 ) , and *activation* of JNK , [ERK] , and p38 pathways , indicating that Act1 negatively regulates CD40- and BAFF mediated signaling events . Positive_regulation EPHB2 NFKB1 15843535 1398457 To identify a molecular basis for this receptor cross-talk , we examined [ERK] activation and *induction* . Positive_regulation EPHB2 NFKB1 15878976 1445442 Induction of Bcl10 activity caused rapid activation of and c-Jun N-terminal kinase (JNK) , but not *activation* of extracellular signal regulated kinase ( [ERK] ) or p38 mitogen activated protein ( MAP ) kinases . Positive_regulation EPHB2 NFKB1 16436136 1516431 The induction of RANTES by SCF or TNF-alpha was mediated by ERK and , respectively , and SCF induced MIP-1beta release was *mediated* by [ERK] . Positive_regulation EPHB2 NFKB1 16709941 1584711 Increased expression of and *activation* of extracellular signal regulated kinase ( [ERK] ) were demonstrated in SM22-PAI+-VSMCs ( fold=NF-kappaB=2.2+/-0.1 , fold=phosphorylated-ERK=1.6+/-0.1 ) . Positive_regulation EPHB2 NFKB1 16870149 1593095 However , this activation of *requires* the PI3K and PKC signaling pathways , but not [ERK] or JNK . Positive_regulation EPHB2 NFKB1 17499198 1739927 Molecular mechanisms that govern attenuation of the levels of mRNAs and proteins of these cytokines and iNOS revealed that the PC extract inhibited LPS stimulated phosphorylation of [ERK] and *activation* of . Positive_regulation EPHB2 NFKB1 17602748 1842182 Reverse signaling initiated from GITRL *induces* activation through [ERK] in the inflammatory activation of macrophages . Positive_regulation EPHB2 NFKB1 18401006 1925769 CyaA enhanced LPS induced phosphorylation of p38 MAPK and [ERK] in DC , and inhibitors of p38 MAPK , MEK , or *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation EPHB2 NFKB1 18442745 1900568 SNP induced the phosphorylation of p38 MAPK and [extracellular regulated kinase (ERK)] , degradation and phosphorylation of IkappaB , and *activation* of . Positive_regulation EPHB2 NFKB1 18603343 1935574 Hydrogen peroxide provoked phosphorylation of [extracellular regulated kinase (ERK)] and c-Jun NH ( 2 ) -terminal kinase ( JNK ) , and *activation* of . Positive_regulation EPHB2 NFKB1 19429670 2106914 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either [ERK] *inhibitor* , p38MAPK inhibitor or inhibitor . Positive_regulation EPHB2 NFKB1 19619321 2118167 Unlike Paclitaxel , ARRY-520 did not induce activation , did not enhance cytokine secretion , nor *induce* [ERK] phosphorylation in Type I EOC cells . Positive_regulation EPHB2 NFKB1 20054486 2177436 HF6-FC exerts its inhibitory effects by suppression of p38 and but *activation* of [ERK] . Positive_regulation EPHB2 NFKB1 20127676 2242101 This effect did not appear to be mediated via effects on early markers of neutrophil activation ( e.g. surface marker expression , shape change , aggregation and superoxide anion generation ) , by direct inhibition of activation ( assessed by cytoplasmic IkappaBalpha proteolysis and NF-kappaB p65 subunit translocation ) and [ERK] *activation* ( determined by specific ERK phosphorylation ) but due to down-regulation ( at protein and mRNA level ) of the survival protein Mcl-1 but not the pro-apoptotic bcl-2 homologue Bim . Positive_regulation EPHB2 NFKBIA 15652235 1364137 PD98059 , a MEK inhibitor , and BAY 11-8702 , an inhibitor , *reduced* [ERK] and NF-kappa B cascade activation , respectively , with little effect on PKC phosphorylation . Positive_regulation EPHB2 NFKBIA 19298870 2080066 5-Hydroxyzerumbone , however , did not affect the degradation of and the *activation* of p38 and [ERK] in LPS treated cells . Positive_regulation EPHB2 NGB 23478801 2771807 Overexpression of *suppressed* serum- and H2O2 stimulated [Erk] activation in HepG2 cells . Positive_regulation EPHB2 NGF 10470855 641409 The activation of [Erk] kinase activity in *response* to was sustained longer in the Rsu-1 transfectants compared with the vector control cells . Positive_regulation EPHB2 NGF 10772818 686259 Both TPA and *induced* a sustained activation and nuclear accumulation of [ERK] that was accompanied by transactivation of a serum response element ( SRE ) -driven reporter and of the c-fos gene . Positive_regulation EPHB2 NGF 10858459 704700 Despite the presence of MKP-3 , [ERK] activity can be further *stimulated* by , but it fails to translocate into the nucleus and consequently to induce immediate-early gene transcription . Positive_regulation EPHB2 NGF 10953000 724209 Despite prolonged Akt and [ERK] signaling *induced* by after BAF treatment has prevented death , the neurons fail to increase protein synthesis , recover ATP levels , or grow . Positive_regulation EPHB2 NGF 11169613 783546 However , *stimulated* phosphorylation of [ERK] , p38 , and Akt in PC12-N09rasWT cells is similar in duration to that in PC12-N09 cells , indicating that the p21(ras) signaling through ERK , p38 , and Akt was not involved in the restoration of normal neurite elongation in PC12-N09 cells . Positive_regulation EPHB2 NGF 11233754 764108 Lead also enhanced *induced* [ERK] phosphorylation and activation , but lead alone did not stimulate ERK . Positive_regulation EPHB2 NGF 11233754 764109 The MAP kinase kinase (MEK) inhibitor , PD98059 , significantly decreased the effect of lead on *induced* neurite outgrowth and [ERK] activation . Positive_regulation EPHB2 NGF 11331872 808913 In PC12 cells , sustained activation of [ERK] *induced* by is essential for neuronal differentiation . Positive_regulation EPHB2 NGF 11701752 878756 The maximal level of nicotine induced ERK phosphorylation was lower than that of the membrane depolarization induced and , to a great extent , the *induced* [ERK] phosphorylation . Positive_regulation EPHB2 NGF 11859925 893713 *induced* [Erk] phosphorylation was rapid in WT11 and C423T cells , but delayed in C436A and C423T/C436A cells . Positive_regulation EPHB2 NGF 11859925 893714 However , basic fibroblast growth factor (bFGF) induced rapid phosphorylation of Erk1/2 , and [ 3H ] thymidine incorporation in NIH3T3 , WT11 , single mutant ( SM ) , and double mutant ( DM ) cells , suggesting that the impaired *induced* [Erk] phosphorylation and thymidine incorporation observed in DM cells are due to the double-cysteine mutations in the trkA receptor . Positive_regulation EPHB2 NGF 11997322 939411 The selective MAP kinase kinase ( MEK1/2 ) inhibitors U0126 and PD-98059 abolished the *induced* [ERK] activation and largely eliminated ( > or = 60 % ) the effects of NGF to inhibit basolateral Na ( + ) /H ( + ) exchange activity and transepithelial HCO absorption in perfused MTALs . Positive_regulation EPHB2 NGF 12067229 954922 At the molecular level , NS 1231 enhanced *induced* signalling events , such as TrkA phosphorylation at the Shc binding site Tyr490 as well as [ERK] activation in PC12 cells . Positive_regulation EPHB2 NGF 12482708 1024518 Mutant ( but not wt ) SHP-2 expression also inhibited *stimulated* [ERK] activation . Positive_regulation EPHB2 NGF 12706116 1082489 In PC12 cells , and EGF *induce* a rapid translocation of [GFP-Erk] that requires Ras and Mek . Positive_regulation EPHB2 NGF 12865160 1111829 The I ( 1 ) -imidazoline receptor in PC12 pheochromocytoma cells reverses *induced* [ERK] activation and induces MKP-2 phosphatase . Positive_regulation EPHB2 NGF 12893270 1117896 The data show that serine residues of the linker region of Smad5 reduce spontaneous transcriptional activity and that *activated* [Erk] does not antagonise BMP signalling at this site . Positive_regulation EPHB2 NGF 14988025 1215005 *Activation* of TrkA and extracellular signal regulated kinase ( [ERK] ) by was inhibited by pretreatment with PP2 , an inhibitor of Src family kinases . Positive_regulation EPHB2 NGF 14988025 1215008 Moreover , *induced* phosphorylation of TrkA and [ERK] was also attenuated by the transfection with a dominant negative src construct . Positive_regulation EPHB2 NGF 15005709 1217453 Introduction of a kinase-defective mutant of BREK into PC12 cells enhanced both [ERK] phosphorylation and neurite outgrowth in *response* to , suggesting that BREK is a negative regulator of NGF induced neuronal differentiation . Positive_regulation EPHB2 NGF 15028221 1222957 For example , the mitogen EGF *induces* a transient [ERK] activation , whereas the neurotrophin induces prolonged ERK activation . Positive_regulation EPHB2 NGF 15153516 1250127 Surprisingly , C3a significantly enhanced *induced* NFAT activation , [ERK] phosphorylation , and MIP-1beta production . Positive_regulation EPHB2 NGF 15207334 1261479 Therefore , we suggest that after inflammation near the cell body , synthesized within the nerve root and DRG *induces* BDNF expression through trkA receptors and intracellular [ERK-MAPK] . Positive_regulation EPHB2 NGF 15385613 1300128 [ERK] *activation* by capsaicin and was also blocked by PI3K inhibitors . Positive_regulation EPHB2 NGF 15890337 1411490 CSK overexpression caused a profound inhibition of *induced* activation of FYN , YES , RAS , and [ERK] and inhibited neurite outgrowth , NGF stimulated integrin directed migration and blocked the NGF induced conversion of GDP-RAC to its GTP bound active state . Positive_regulation EPHB2 NGF 15965078 1423458 Antioxidant N-acetylcysteine blocks *induced* [H2O2/ERK] signaling in PC12 cells . Positive_regulation EPHB2 NGF 15965078 1423461 We found that increased intracellular H2O2 concentration and *activated* [ERK] but failed to affect intracellular superoxide level . Positive_regulation EPHB2 NGF 15965078 1423463 These findings demonstrate that NAC blocks the *induced* [H2O2/ERK] signaling in PC12 cells . Positive_regulation EPHB2 NGF 16157584 1475832 Accordingly , selective down-regulation of Rin in PC6 cells suppressed neurotrophin elicited activation of b-Raf and p38 , without obvious effects on *induced* [ERK] activation . Positive_regulation EPHB2 NGF 16408304 1540235 Ndrg4 enhances *induced* [ERK] activation uncoupled with Elk-1 activation . Positive_regulation EPHB2 NGF 16408304 1540236 PC12 cell lines stably expressing increased levels of Ndrg4 protein display enhanced *induced* phosphorylation of MEK and [ERK] . Positive_regulation EPHB2 NGF 16606368 1556607 Levels of TrkA receptor phosphorylation and downstream [ERK] activation *induced* by were not influenced by GnT-VB expression . Positive_regulation EPHB2 NGF 16914291 1672877 Finally , *dependent* [ERK] activation and H2O2 production is pertussis toxin sensitive . Positive_regulation EPHB2 NGF 17111371 1667746 *induced* persistent [ERK] and AP-1 activities , whereas upon EGF and anisomycin exposures , their activities were only weakly and transiently induced . Positive_regulation EPHB2 NGF 18094051 1869023 It increases [Erk] *activation* by , and this increased activation induces differentiation of neuroblastoma cell lines . Positive_regulation EPHB2 NGF 18299325 1903869 Importantly , activates TrkA tyrosine phosphorylation , *induces* [Erk] and Akt activation , and causes PC12 cell differentiation . Positive_regulation EPHB2 NGF 18758136 1968961 We describe here our finding that the *induced* phosphorylation of both [ERK] and Akt are accelerated by MCC-257 . Positive_regulation EPHB2 NGF 19029810 2001553 In classical experiments , PC12 cells proliferated after transient ERK activation by epidermal growth factor , but terminally differentiated after more sustained [ERK] *activation* by . Positive_regulation EPHB2 NGF 20127820 2242151 In addition , in the NRAGE suppressed cells , *induced* [ERK] activation is increased and this activation is MEK dependent . Positive_regulation EPHB2 NGF 20127820 2242152 Conversely , NRAGE overexpression significantly represses *induced* [ERK] activation . Positive_regulation EPHB2 NGF 20170684 2424437 released from target cells activates TrkA on axon terminals and *triggers* activation of PI3K/Akt , [MEK/ERK] , and PLC? ( phospholipase C ) signaling pathways . Positive_regulation EPHB2 NGF 21807900 2476847 PC12 cells exhibit precise temporal control of growth factor signaling in which stimulation with epidermal growth factor (EGF) leads to transient extracellular signal regulated kinase ( ERK ) activity and cell proliferation , whereas stimulation *leads* to sustained [ERK] activity and differentiation . Positive_regulation EPHB2 NGF 22065583 2516982 Sustained [ERK] activity *induced* by , as compared with transient activity induced by EGF , is critical to the differentiation of these cells . Positive_regulation EPHB2 NGF 22065583 2516983 To characterize the transcriptional program activated preferentially by NGF , we compared global gene expression profiles between cells treated with NGF and EGF for 2-4 h , when sustained [ERK] signaling in *response* to is most distinct from the transient signal elicited by EGF . Positive_regulation EPHB2 NGF 24006492 2856247 Of interest , although both phosphoinositide 3-kinase-Akt and [Erk] signaling are *activated* by , NGF induced Akt-phosphorylation appears to be more sensitively affected by perturbed endosomal pH . Positive_regulation EPHB2 NGF 8662831 367396 Importantly , IL-6 does not enhance [ERK] phosphorylation in the *presence* of either or EGF . Positive_regulation EPHB2 NGF 9525930 495537 Induction of neuronal differentiation of the rat pheochromocytoma cell line , PC12 cells , by *requires* activation of the mitogen activated protein (MAP) kinase or extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 NGF 9706879 526340 *induces* transient but not sustained activation of [ERK] in PC12 mutant cells incapable of differentiating . Positive_regulation EPHB2 NISCH 15808658 1391233 A significant increase in liver regeneration , as assessed by the percentage of liver weight/body weight was demonstrated in females ( 184 % +/- 24 % ) and male mice given 17beta-E ( 168 % +/- 22 % ) compared with male mice given vehicle ( 9 % +/- 4 % ) . 17beta-E significantly down-regulated JNK and p38alpha activities , whereas *promoted* p38beta and [ERK] activation . Positive_regulation EPHB2 NLN 16076765 1442260 also *induced* activation of [ERK] , JNK , and p38 signaling pathways and produced an increase of oxidative stress in A549 cells . Positive_regulation EPHB2 NME1 23416464 2764763 siRNA mediated knockdown of Nm23H1/2 allowed 293/RGS19 cells to partially recover their ERK responses to serum treatment , while overexpression of in HEK293 cells *suppressed* the serum induced [ERK] response . Positive_regulation EPHB2 NMU 22493291 2601761 Moreover , the *induced* [p-ERK] increase was attenuated by PKA inhibition and activation of PKA by foskolin would mimic the NMU induced I ( A ) increase . Positive_regulation EPHB2 NOS2 12426209 1014366 Treatment of VSMCs with PDGF or EGF alone potently induced [ERK] phosphorylation and DNA synthesis but did not *induce* NF-kappaB activation or expression . Positive_regulation EPHB2 NOS2 16327214 1490979 [ERK] activation , *induction* , and NO production following LPS stimulation were all markedly inhibited in the presence of U0126 , an ERK inhibitor . Positive_regulation EPHB2 NOS3 12937820 1132996 E ( 2 ) inhibited the expression of [ERK] , phosphorylated ERK and *induced* the expression . Positive_regulation EPHB2 NOTCH1 23533157 2804076 Activated in turn is *required* for sustained [ERK] activation . Positive_regulation EPHB2 NOX1 10764657 684098 JNK and p38 MAPK , but not [ERK] , activation was *inhibited* by an inhibitor of . Positive_regulation EPHB2 NOX1 10965882 728027 In the presence of a inhibitor , diphenyleneiodonium ( DPI ) or an antioxidant , alpha-tocopherol , Ang II-induced protein tyrosine phosphorylation of two major proteins ( p120 , p70 ) and [ERK] activation were markedly *reduced* , whereas ERK activation by epidermal growth factor was unaffected . Positive_regulation EPHB2 NOX1 18206959 1863941 inhibitor , apocynin , *prevented* leptin 's effect on BP , [ERK] , Na ( + ) , K ( + ) -ATPase/Na ( + ) excretion and NO formation at all time points . Positive_regulation EPHB2 NOX1 19804648 2153911 mediates beta-amyloid peptide *induced* activation of [ERK] in hippocampal organotypic cultures . Positive_regulation EPHB2 NOX1 19804648 2153915 We also examined whether phospho-ERK was regulated by redox signaling mechanisms and found that increases in active [ERK] induced by Abeta and nicotine were *blocked* by inhibitors of . Positive_regulation EPHB2 NOX1 19804648 2153919 Our findings indicate that dependent redox signaling is *required* for Abeta induced activation of [ERK] , and suggest a similar mechanism may occur during early stages of Alzheimer 's disease . Positive_regulation EPHB2 NOX1 21276422 2398174 Moreover , pharmacological inhibition also effectively *attenuates* serum dependent growth and phosphorylation of AKT and [ERK] . Positive_regulation EPHB2 NOX1 21660950 2442614 EGF induced [ERK-activation] downstream of FAK *requires* . Positive_regulation EPHB2 NOX1 21907719 2501451 Moreover , inhibition or antioxidant MPG *prevented* both A ( 1 ) AR-mediated arrhythmias and [ERK] phosphorylation . Positive_regulation EPHB2 NOX1 22483454 2578974 These results suggested that *mediated* ROS and subsequent [ERK] and p38 MAPK activation play important roles in ECM accumulation in the renal tubulointerstitium . Positive_regulation EPHB2 NOX1 23443487 2749208 Blocking of the activity of with diphenylene iodonium *inhibited* ROS production , activation of extracellular signal regulated kinase ( [ERK] ) , and the expression of RANK , PU.1 and MITF . Positive_regulation EPHB2 NOX3 10764657 684099 JNK and p38 MAPK , but not [ERK] , activation was *inhibited* by an inhibitor of . Positive_regulation EPHB2 NOX3 10965882 728028 In the *presence* of a inhibitor , diphenyleneiodonium ( DPI ) or an antioxidant , alpha-tocopherol , Ang II-induced protein tyrosine phosphorylation of two major proteins ( p120 , p70 ) and [ERK] activation were markedly reduced , whereas ERK activation by epidermal growth factor was unaffected . Positive_regulation EPHB2 NOX3 18206959 1863942 inhibitor , apocynin , *prevented* leptin 's effect on BP , [ERK] , Na ( + ) , K ( + ) -ATPase/Na ( + ) excretion and NO formation at all time points . Positive_regulation EPHB2 NOX3 19804648 2153912 mediates beta-amyloid peptide *induced* activation of [ERK] in hippocampal organotypic cultures . Positive_regulation EPHB2 NOX3 19804648 2153916 We also examined whether phospho-ERK was regulated by redox signaling mechanisms and found that increases in active [ERK] induced by Abeta and nicotine were *blocked* by inhibitors of . Positive_regulation EPHB2 NOX3 19804648 2153920 Our findings indicate that dependent redox signaling is *required* for Abeta induced activation of [ERK] , and suggest a similar mechanism may occur during early stages of Alzheimer 's disease . Positive_regulation EPHB2 NOX3 21276422 2398175 Moreover , pharmacological inhibition also effectively *attenuates* serum dependent growth and phosphorylation of AKT and [ERK] . Positive_regulation EPHB2 NOX3 21660950 2442615 EGF induced [ERK-activation] downstream of FAK *requires* . Positive_regulation EPHB2 NOX3 21907719 2501452 Moreover , inhibition or antioxidant MPG *prevented* both A ( 1 ) AR-mediated arrhythmias and [ERK] phosphorylation . Positive_regulation EPHB2 NOX3 22483454 2578975 These results suggested that mediated ROS and subsequent [ERK] and p38 MAPK *activation* play important roles in ECM accumulation in the renal tubulointerstitium . Positive_regulation EPHB2 NOX3 23443487 2749209 Blocking of the activity of with diphenylene iodonium *inhibited* ROS production , activation of extracellular signal regulated kinase ( [ERK] ) , and the expression of RANK , PU.1 and MITF . Positive_regulation EPHB2 NOX4 10764657 684100 JNK and p38 MAPK , but not [ERK] , activation was *inhibited* by an inhibitor of . Positive_regulation EPHB2 NOX4 10965882 728029 In the presence of a inhibitor , diphenyleneiodonium ( DPI ) or an antioxidant , alpha-tocopherol , Ang II-induced protein tyrosine phosphorylation of two major proteins ( p120 , p70 ) and [ERK] activation were markedly *reduced* , whereas ERK activation by epidermal growth factor was unaffected . Positive_regulation EPHB2 NOX4 17940286 1835538 Rac1 , therefore , bifurcates Tat signaling , leading to concurrent but separate dependent [Ras/ERK] *activation* , and Nox2 dependent JNK activation . Positive_regulation EPHB2 NOX4 18206959 1863943 inhibitor , apocynin , *prevented* leptin 's effect on BP , [ERK] , Na ( + ) , K ( + ) -ATPase/Na ( + ) excretion and NO formation at all time points . Positive_regulation EPHB2 NOX4 19804648 2153913 mediates beta-amyloid peptide *induced* activation of [ERK] in hippocampal organotypic cultures . Positive_regulation EPHB2 NOX4 19804648 2153917 We also examined whether phospho-ERK was regulated by redox signaling mechanisms and found that increases in active [ERK] induced by Abeta and nicotine were *blocked* by inhibitors of . Positive_regulation EPHB2 NOX4 19804648 2153921 Our findings indicate that dependent redox signaling is *required* for Abeta induced activation of [ERK] , and suggest a similar mechanism may occur during early stages of Alzheimer 's disease . Positive_regulation EPHB2 NOX4 21276422 2398176 Moreover , pharmacological inhibition also effectively *attenuates* serum dependent growth and phosphorylation of AKT and [ERK] . Positive_regulation EPHB2 NOX4 21660950 2442616 EGF induced [ERK-activation] downstream of FAK *requires* . Positive_regulation EPHB2 NOX4 21907719 2501453 Moreover , inhibition or antioxidant MPG *prevented* both A ( 1 ) AR-mediated arrhythmias and [ERK] phosphorylation . Positive_regulation EPHB2 NOX4 22483454 2578976 These results suggested that mediated ROS and subsequent [ERK] and p38 MAPK *activation* play important roles in ECM accumulation in the renal tubulointerstitium . Positive_regulation EPHB2 NOX4 23443487 2749210 Blocking of the activity of with diphenylene iodonium *inhibited* ROS production , activation of extracellular signal regulated kinase ( [ERK] ) , and the expression of RANK , PU.1 and MITF . Positive_regulation EPHB2 NOX4 24095877 2867691 In vitro , Ang II suppressed RECK expression in adult mouse cardiac fibroblasts ( CF ) via *dependent* [ERK/Sp1] activation , but induced MMPs 2 , 14 and 9 via NF-?B , AP-1 and/or Sp1 activation . Positive_regulation EPHB2 NOX5 10764657 684097 JNK and p38 MAPK , but not [ERK] , activation was *inhibited* by an inhibitor of . Positive_regulation EPHB2 NOX5 10965882 728025 In the presence of a inhibitor , diphenyleneiodonium ( DPI ) or an antioxidant , alpha-tocopherol , Ang II-induced protein tyrosine phosphorylation of two major proteins ( p120 , p70 ) and [ERK] activation were markedly *reduced* , whereas ERK activation by epidermal growth factor was unaffected . Positive_regulation EPHB2 NOX5 18206959 1863940 inhibitor , apocynin , *prevented* leptin 's effect on BP , [ERK] , Na ( + ) , K ( + ) -ATPase/Na ( + ) excretion and NO formation at all time points . Positive_regulation EPHB2 NOX5 19804648 2153910 mediates beta-amyloid peptide *induced* activation of [ERK] in hippocampal organotypic cultures . Positive_regulation EPHB2 NOX5 19804648 2153914 We also examined whether phospho-ERK was regulated by redox signaling mechanisms and found that increases in active [ERK] induced by Abeta and nicotine were *blocked* by inhibitors of . Positive_regulation EPHB2 NOX5 19804648 2153918 Our findings indicate that dependent redox signaling is *required* for Abeta induced activation of [ERK] , and suggest a similar mechanism may occur during early stages of Alzheimer 's disease . Positive_regulation EPHB2 NOX5 21276422 2398173 Moreover , pharmacological inhibition also effectively *attenuates* serum dependent growth and phosphorylation of AKT and [ERK] . Positive_regulation EPHB2 NOX5 21660950 2442613 EGF induced [ERK-activation] downstream of FAK *requires* . Positive_regulation EPHB2 NOX5 21907719 2501450 Moreover , inhibition or antioxidant MPG *prevented* both A ( 1 ) AR-mediated arrhythmias and [ERK] phosphorylation . Positive_regulation EPHB2 NOX5 22427510 2594312 Although catalytically inactive , potently *activated* [ERK] in HVSMC , and increased expression of Nox5-e promoted HVSMC proliferation . Positive_regulation EPHB2 NOX5 22427510 2594313 can inhibit Nox5 activity and *activate* [ERK] and HVSMC proliferation . Positive_regulation EPHB2 NOX5 22483454 2578973 These results suggested that mediated ROS and subsequent [ERK] and p38 MAPK *activation* play important roles in ECM accumulation in the renal tubulointerstitium . Positive_regulation EPHB2 NOX5 23443487 2749206 Blocking of the activity of with diphenylene iodonium *inhibited* ROS production , activation of extracellular signal regulated kinase ( [ERK] ) , and the expression of RANK , PU.1 and MITF . Positive_regulation EPHB2 NPFF 22981806 2697867 rapidly and transiently *stimulated* [ERK] . Positive_regulation EPHB2 NPFF 22981806 2697868 H89 , a selective inhibitor of cyclic AMP dependent protein kinase A (PKA) , inhibited the NPFF activated ERK pathway , indicating the involvement of PKA in the *induced* [ERK] activation . Positive_regulation EPHB2 NPFF 22981806 2697875 Down-regulation of nitric oxide synthases also attenuated *induced* [ERK] activation , suggesting that a nitric oxide synthase dependent pathway is involved . Positive_regulation EPHB2 NPM1 16909118 1692144 The *induced* [MEK/ERK] activation is independent of c-Raf as evidenced by the lack of MEK1/2 and ERK1/2 phosphorylation upon c-Raf inactivation by two different inhibitors , RI and ZM336372 , and by its siRNA mediated depletion . Positive_regulation EPHB2 NPPA 16527839 1561693 LPA , but not , *enhances* [ERK] phosphorylation and induces cell rounding together with a dramatic reorganization of actin filaments . Positive_regulation EPHB2 NPS 12621153 1066353 significantly *stimulated* capillary network formation of cultured endothelial cells by cGK stimulation and subsequent [Erk12] activation . Positive_regulation EPHB2 NPS 22070748 2517016 In addition to inducing high quantities of ROS , *attenuated* levels of Akt and [Erk] phosphorylation . Positive_regulation EPHB2 NPS 23459257 2799482 Herein , we investigate whether also *activate* [ERK] in DC in vitro . Positive_regulation EPHB2 NPY 10565839 567422 However , *caused* a rapid ( already maximal after 30 s ) and concentration dependent ( maximum at 10-100 nM ) activation of extracellular signal regulated kinase ( [ERK] ) as assessed by immunoblotting with epitope-specific , antiphosphotyrosine antibodies and in some cases enzymatically . Positive_regulation EPHB2 NPY 10565839 567423 [ERK] *activation* by 100 nM was abolished by the Y ( 1 ) NPY receptor antagonist BIBP 3226 ( 1 microM ) , pertussis toxin treatment ( 100 ng ml(-1) overnight ) , the mitogen activated protein kinase (MAPK) kinase inhibitor PD 98059 ( 100 microM ) , and the phosphatidylinositol-3-kinase inhibitor wortmannin ( 100 nM ) . Positive_regulation EPHB2 NPY 10565839 567443 However , *activates* [ERK] by a pathway involving Y ( 1 ) receptors , pertussis toxin-sensitive G proteins , and phosphatidylinositol-3-kinase , whereas PKC may not be involved . Positive_regulation EPHB2 NPY 11914588 925277 PD 10 , 25 and 50 microM ) completely blocked *induced* [ERK] activity . Positive_regulation EPHB2 NPY 15579142 1344806 Taken together , our results demonstrate that the *activation* of [ERK] and p38 and also the changes in and BDNF expression may occur in different populations of DRG neurons after CCI , partially through alterations in the target derived NGF . Positive_regulation EPHB2 NPY 15992362 1446868 Stimulation of the Gi-coupled and Gq-coupled muscarinic M1 acetylcholine receptors , but not the Gs-coupled dopamine D1 receptor , *led* to the activation of extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 NPY 24699455 2949433 We found that *induced* a dose dependent migration of human monocyte derived immature DCs through the engagement of NPY Y1 receptor and the activation of [ERK] and p38 mitogen activated protein kinases . Positive_regulation EPHB2 NPY4R 19778233 2141051 The induction of TNF-alpha and TGF-beta1 by silica was suppressed by Src *inhibitor* ( ) , [ERK] inhibitor ( PD98059 ) , but not by p38 kinase inhibitor ( SB203580 ) . Positive_regulation EPHB2 NPY6R 10666504 665612 The major aim of the present study was to examine the mechanism of decrease in ERK activity by adrenomedullin and to identify the *role* of protein in the decrease in [ERK] activity , using okadaic acid [ 9,10-Deepithio-9,10-didehydroacanthifolicin ] , a selective inhibitor of PP2A at low nanomolar concentrations . Positive_regulation EPHB2 NPY6R 10777553 686851 The Src family kinase inhibitor , ( 20 nM-20 microM ) *attenuated* CCh stimulated EGFR and [ERK] phosphorylation and potentiated chloride secretory responses to CCh . Positive_regulation EPHB2 NPY6R 13679375 1164645 Furthermore , we found that activation of protein by Coll I was *required* for both Coll I-mediated activation of [Erk] , and inhibition of Fas induced caspase-8 activation and apoptosis . Positive_regulation EPHB2 NPY6R 17875324 1843342 Interestingly , however , *had* no significant effect on the activation of NF-kappaB , or on p42/44 [ERK] , p46/54 JNK or p38 MAPK phosphorylation . Positive_regulation EPHB2 NPY6R 19239475 2054866 The [ERK] *activation* , NF-kB translocation and PDGF-BB production were blocked by , U73122 and PD98059 . Positive_regulation EPHB2 NPY6R 19625610 2142922 Especially , phosphorylation of caveolin-1 is attenuated by AG1478 , herbimycin A ( tyrosine kinase inhibitors ) , and pyrazolopyrimidine 2 ( PP2 , Src inhibitor ) and EGF induced [ERK] *activation* was blocked by , methyl-beta-cyclodextrin ( MbetaCD ) , caveolin-1 small interfering RNA ( siRNA ) , LY-294002 [ phosphoinositol-3 kinase inhibitor ( PI3K ) ] , and Akt inhibitor . Positive_regulation EPHB2 NPY6R 21954875 2546914 In addition , the Src tyrosine kinase inhibitor , , *blocked* ISO mediated both Akt and [ERK] activation and heavily suppressed viability . Positive_regulation EPHB2 NPY6R 23775084 2820306 We show that both chemical suppression and siRNA silencing of in T-cells *resulted* in sustained phosphorylation of MEK and [ERK] following stimulation with phorbol 12-myristate 13-acetate and ionomycin . Positive_regulation EPHB2 NPY6R 23775084 2820324 Similarly , in SLE T-cells , suppression of *resulted* in increased [MEK/ERK] phosphorylation , enhanced DNMT1 expression and suppressed expression of the methylation-sensitive CD70 gene . Positive_regulation EPHB2 NR1I3 10935495 580636 The mutant *causes* a calcium dependent activation of the extracellular signal regulated protein kinase ( [ERK] ) 1/2 and Jun-N-terminal kinase/stress activated ( JNK/ SAPK ) pathways , but not P38 MAP kinase . Positive_regulation EPHB2 NR1I3 11097627 755786 We analyzed the kinetics of *activation* of [p42ERK] and PLA(2) by the in response to Ca ( 2+ ) , Co ( 2+ ) , and Pb ( 2+ ) . Positive_regulation EPHB2 NR1I3 11390379 849511 The functional importance of their interaction was documented by transiently expressing the CaR in M2 melanoma cells that lack filamin , or in A7 melanoma cells that stably express filamin , and demonstrating that the *activated* [ERK] only in the presence of filamin . Positive_regulation EPHB2 NR1I3 21843504 2477377 Ectopic expression of testin in HEK293 cells stably expressing the CaR enhanced CaR stimulated Rho activity but had no effect on *stimulated* [ERK] signalling . Positive_regulation EPHB2 NRAS 10092503 600519 Recently , radicicol was reported as an inhibitor of *induced* [ERK] activation . Positive_regulation EPHB2 NRAS 10340949 616234 ( 2 ) active is *sufficient* for [ERK] activation but is insufficient for maximal activation of JNK or p38 ; Positive_regulation EPHB2 NRAS 10402467 628945 and MAP kinase kinase (MEK) were *necessary* and sufficient for uPA induced [ERK] activation and stimulation of cellular migration , as demonstrated in experiments with dominant negative and constitutively active mutants of these signaling proteins . Positive_regulation EPHB2 NRAS 10571061 568491 function was *required* for [ERK] activation by phorbol esters in cardiac myocytes , but not in cardiac fibroblasts . Positive_regulation EPHB2 NRAS 10636931 660198 These data indicate that rPMT employs G ( q/11 ) family heterotrimeric G proteins to induce *dependent* [Erk] activation via protein kinase C-independent `` transactivation '' of the epidermal growth factor receptor . Positive_regulation EPHB2 NRAS 10667210 578488 Treatment of fibroblast cells with this compound had very little effect on *mediated* activation of [ERK] and JUN kinase activities . Positive_regulation EPHB2 NRAS 10749883 698489 These data clearly demonstrate that the alpha-thrombin induced activation coordinately *regulates* [ERK] and PI 3-kinase activities , both of which are required for expression of cyclin D1 protein and progression through G ( 1 ) . Positive_regulation EPHB2 NRAS 10898494 712064 Here , we analyzed the effects of Vav on three known downstream targets of , i. e. *activation* of [ERK] and NFAT , and up-regulation of the activation antigen CD69 . Positive_regulation EPHB2 NRAS 10898494 712078 Conversely , however , dominant negative Vav did not inhibit NFAT and [ERK] activation or CD69 expression *induced* by an active mutant . Positive_regulation EPHB2 NRAS 10962574 727228 These results suggest that Smad4 acts inhibiting *dependent* [Erk] signalling activity in Ras transformed keratinocytes . Positive_regulation EPHB2 NRAS 10976990 729636 In contrast to their implication in epidermal growth factor (EGF) receptor tyrosine kinase signaling , the adaptor protein Shc , the Grb2/Sos complex , and the small G protein were not *involved* in the activation of [Erk] induced by either LPA or PGF2alpha in MC3T3-E1 cells , suggesting that activation of Erk by Gi and Gq protein coupled receptors is Ras independent in these cells . Positive_regulation EPHB2 NRAS 11005808 752486 Surprisingly , a role for in the heat shock response was eliminated by the failure of a dominant negative Ras ( Asn-17 ) mutant to *inhibit* [ERK] MAPK activation and the failure to observe increases in Ras . Positive_regulation EPHB2 NRAS 11018025 752779 Expression of a dominant negative mutant of Ras also did not significantly impair calcium induced ERK activation , indicating that calcium mediated [ERK] activation does not *require* active . Positive_regulation EPHB2 NRAS 11027277 738758 PI3-K and endocytosis may also regulate ERK signaling at a second site downstream of Ras , since both rapid [ERK] activation and the dependent *activation* of the MAP kinase kinase kinase B-Raf are blocked by inhibition of either PI3-K or endocytosis . Positive_regulation EPHB2 NRAS 11088001 764960 We show that the activation of [ERK] via SSTR1 is mediated by the betagamma subunit of a pertussis toxin-sensitive G-protein and *requires* both the small G protein and the serine/threonine kinase Raf-1 . Positive_regulation EPHB2 NRAS 11262176 796251 However , *induced* activation of the mitogen activated protein kinase [ERK] has been suggested to play a critical role in either growth or differentiation in different model systems . Positive_regulation EPHB2 NRAS 11269657 797345 Arsenite inhibits *dependent* activation of [ERK] but activates ERK in the presence of oncogenic Ras in baboon vascular smooth muscle cells . Positive_regulation EPHB2 NRAS 11418608 843271 VPA induced *activation* of [ERK] was blocked by the mitogen activated protein kinase/ERK kinase inhibitor PD098059 and dominant negative and Raf mutants but not by dominant negative stress activated protein kinase/ERK kinase and mitogen activated protein kinase kinase 6 mutants . Positive_regulation EPHB2 NRAS 11574537 882425 NT-stimulated Erk activity requires Ras activation because overexpression of the dominant negative Ras mutant almost completely *inhibits* the [Erk] activation . Positive_regulation EPHB2 NRAS 11681720 873912 Overexpression of dominant negative mutant *suppressed* GH-stimulated [ERK] activation . Positive_regulation EPHB2 NRAS 11682481 888560 In contrast , activation of [ERK] was largely *dependent* on . Positive_regulation EPHB2 NRAS 11791173 901784 Here we determined the efficacy of Shc and N-Shc toward Erk activation in NGF treated PC12 cells , and found that N-Shc transduced dependent [Erk] *activation* less efficiently than Shc . Positive_regulation EPHB2 NRAS 11799108 922216 In contrast , Ras induced focus formation , platelet derived growth factor ( PDGF ) - , or Ras induced phospho-Akt levels and cell adhesion to fibronectin were affected by T35S and Y40C EDMs , whereas PDGF- or *induced* [phospho-Erk] levels were affected only by the T35S EDM , implying that a more limited set of Ras mediated pathways participate in these phenotypes . Positive_regulation EPHB2 NRAS 11821947 908916 To investigate the specific role of A-Raf in this process we generated A-Raf deficient mouse embryonic fibroblasts ( MEFs ) and embryonic stem ( ES ) cells by gene targeting and characterized their ability to undergo proliferation , differentiation , apoptosis , [ERK] *activation* , and transformation by oncogenic and Src . Positive_regulation EPHB2 NRAS 12082537 958582 In exponentially growing cells , oncogenic *had* no effect on proliferation rates , [Erk] phosphorylation , or the level of cyclin D1 , and Ras-induction did not confer serum independent growth . Positive_regulation EPHB2 NRAS 12193071 981003 Thus , p38 MAP kinase stimulation could perhaps partially account for ET-1 contractive properties , whereas ET-1 induced cell proliferation occurs primarily via *dependent* activation of the [ERK] . Positive_regulation EPHB2 NRAS 12364324 1019141 GLP1 stimulated activation of [Erk] is blocked by inhibitors of MEK , but GLP1 does not *induce* the activation of A-Raf , B-Raf , C-Raf , or . Positive_regulation EPHB2 NRAS 12379659 1034801 Moreover , Erbin inhibits the [Erk] *activation* by active , while it fails to do so in the presence of active Raf-1 . Positive_regulation EPHB2 NRAS 12439598 1016861 mediated *activation* of [ERK] by cisplatin induces cell death independently of p53 in osteosarcoma and neuroblastoma cell lines . Positive_regulation EPHB2 NRAS 12439598 1016865 Our results suggest that cisplatin induced activation of [ERK] is *mediated* by . Positive_regulation EPHB2 NRAS 12446729 1037529 *dependent* [ERK] activation by the human G ( s ) -coupled serotonin receptors 5-HT4 ( b ) and 5-HT7 ( a ) . Positive_regulation EPHB2 NRAS 12473665 1055930 *mediated* peak stimulation of [ERK] by PACAP , whereas Rap1 was necessary for the sustained activation phase . Positive_regulation EPHB2 NRAS 12600818 1085059 was *required* for maximal activation of extracellular signal regulated kinase ( [ERK] ) and Jun amino terminal kinase (JNK) as well as AP-1 and NF-kappaB transcriptional activities , but not for activation of IkappaB kinase (IKK)-beta , an upstream activator of NF-kappaB . Positive_regulation EPHB2 NRAS 12706116 1082490 In PC12 cells , NGF and EGF induce a rapid translocation of [GFP-Erk] that *requires* and Mek . Positive_regulation EPHB2 NRAS 12855697 1134966 This unresponsiveness is associated with the constitutive activation of the small G protein , Rap1 , and the lack of dependent *activation* of [ERK] . Positive_regulation EPHB2 NRAS 12902401 1121107 LPA induced chemotaxis is markedly dependent on activation of PTX-sensitive heterotrimeric G-proteins , on activation of the small GTPases , Rac and RhoA , and on GTPase dependent *activation* of [ERK] . Positive_regulation EPHB2 NRAS 12966092 1164379 EGFR phosphorylation , in turn , led to *dependent* [Erk] activation . Positive_regulation EPHB2 NRAS 12975377 1164603 This inhibition is specific to Cot , because *induced* [ERK] and IkappaB kinase induced NF-kappaB activation are not significantly affected by hKSR-2 co-expression . Positive_regulation EPHB2 NRAS 14607972 1162190 Functionally , Rap1 either interferes with mediated [ERK] *activation* or activates ERK independently of Ras in a cell-context dependent manner . Positive_regulation EPHB2 NRAS 15029245 1228106 Developmentally regulated *role* for in coupling NMDA glutamate receptors to Ras , [Erk] and CREB . Positive_regulation EPHB2 NRAS 15062121 1230752 Signal transduction : implications for *dependent* [ERK] signaling . Positive_regulation EPHB2 NRAS 15516985 1343131 was also constitutively active in patient NK cells , and exposure of cells to the Ras inhibitor FTI2153 or to dominant-negative-Ras *resulted* not only in [ERK] inhibition but also in enhanced apoptosis in both the presence and absence of anti-Fas . Positive_regulation EPHB2 NRAS 15630138 1362338 The Sprouty related Ena/VASP homology 1-domain containing protein ( Spred)-1 has recently been identified as a negative regulator of growth factor mediated , *dependent* [ERK] activation . Positive_regulation EPHB2 NRAS 15677464 1388360 In contrast , [Raf-MEK-ERK] and phosphatidylinositol 3-kinase-Akt pathways , which are fundamental to proliferation and differentiation , are *activated* by both H-Ras and . Positive_regulation EPHB2 NRAS 16041367 1437718 Prohibitin is required for induced [Raf-MEK-ERK] *activation* and epithelial cell migration . Positive_regulation EPHB2 NRAS 16088958 1460662 Inhibition of significantly *blocked* the activation of Raf-1 , [ERK] , and c-Jun and the stimulation of COX-2 expression in response to serum . Positive_regulation EPHB2 NRAS 16214133 1468841 In addition , transfection of ES cells with DN-Src , or DN-Ras partially inhibited 8-Br-cAMP induced ERK1/2 and consequently PLD activation , whereas cotransfection of DN-Src and DN-Ras completely inhibited ERK1/2 and PLD activation , suggesting that Src and independently *regulate* [ERK/PLD] activation . Positive_regulation EPHB2 NRAS 16214133 1468897 Taken together , these results demonstrate a novel pathway in ES cells that 8-Br-cAMP activate PLD through PKA and ERK1/2 and this [ERK/PLD] activation by 8-Br-cAMP is *mediated* by Src and , separately . Positive_regulation EPHB2 NRAS 16267393 1479013 A substitution that mimics constitutive phosphorylation ( S518D ) abrogated the ability of merlin to suppress effects of the Ras-ERK signaling pathway such as Ras induced SRE transactivation , Elk mediated SRE transactivation , *induced* [ERK] phosphorylation and Ras induced focus formation . Positive_regulation EPHB2 NRAS 16301319 1511019 It inhibits mediated *activation* of [ERK] in response to growth factors . Positive_regulation EPHB2 NRAS 16436505 1540513 In addition , we demonstrated that Tat activation of , but not of Rac , *induces* [ERK] phosphorylation . Positive_regulation EPHB2 NRAS 16478791 1528370 APC inhibits [ERK] pathway activation and cellular proliferation *induced* by . Positive_regulation EPHB2 NRAS 16478791 1528392 The GTP loading and the protein level of mutated RAS were decreased in cells with reduced ERK activity as a result of APC overexpression , indicating that APC regulates induced [ERK] *activation* at least partly by reduction of the RAS protein level . Positive_regulation EPHB2 NRAS 16709153 1598864 However , a biochemical link between PE and GAP inactivation is missing and GEF stimulation is hard to reconcile with the observation that dominant negative S17N-Ras does not compromise *dependent* [ERK] ( extracellular-signal regulated kinase ) activation by PE . Positive_regulation EPHB2 NRAS 16860436 1632243 Inhibitors of epidermal growth factor receptor (EGFR) ( AG 1478 ) , and Raf , as well as antioxidants *inhibited* activation of [ERK] and Akt , while the Src inhibitor PP2 had no effect . Positive_regulation EPHB2 NRAS 16959871 1646780 Overexpression of G ( alpha- ) transducin , showed that G ( betagamma ) -subunit activation is only partially required for ERK1/2 phosphorylation and does not play a role in p38 MAPK phosphorylation , whereas overexpression of a dominant negative ( Ras N17 ) *attenuated* both [ERK] and p38 MAPK activation . Positive_regulation EPHB2 NRAS 17045653 1666545 In the present study , we investigated the *role* of in FLG- and LPS mediated signaling in [ERK] activation in chicken heterophils . Positive_regulation EPHB2 NRAS 17174095 1688102 Kinase Suppressor of Ras (KSR) is a molecular scaffold that interacts with the core kinase components of the ERK cascade , Raf , MEK , and ERK and provides spatial and temporal regulation of *dependent* [ERK] cascade signaling . Positive_regulation EPHB2 NRAS 17374607 1734755 Axin inhibits cellular proliferation and [ERK] pathway activation *induced* by either epidermal growth factor or , indicating a role of Axin in the regulation of growth induced by ERK pathway activation . Positive_regulation EPHB2 NRAS 17440079 1729378 Moreover , although the initial activation of Ras and PAK2 are distinctly regulated , TGF-beta stimulated PAK2 activity is required for *dependent* [ERK] phosphorylation and Elk-1 transcription . Positive_regulation EPHB2 NRAS 17450518 1761004 HUVEC stably transfected with dominant negative Ras abrogated XIAP preservation by cPGI ( 2 ) while constitutive active *increased* [ERK] phosphorylation and protected XIAP from degradation . Positive_regulation EPHB2 NRAS 17562163 1798035 Inhibitors of growth factor receptor ( AG1478 ) and Src ( PP2 ) and the antioxidant N-acetylcysteine did not affect activation of ERK and Akt , while the and Raf inhibitors *inhibited* activation of [ERK] , but not Akt . Positive_regulation EPHB2 NRAS 18275061 1924759 As further support for Ras mediated signaling , constitutively active ( ca ) *promoted* [MEK/ERK] activation and osteoclast survival , which was blocked by inhibition of PI3K or Raf . Positive_regulation EPHB2 NRAS 18604197 1941628 Thus , IQGAP3 regulates the promotion of cell proliferation through dependent [ERK] *activation* . Positive_regulation EPHB2 NRAS 20179705 2222198 Induction of [ERK] signalling requires direct binding of the drug to the ATP binding site of one kinase of the dimer and is *dependent* on activity . Positive_regulation EPHB2 NRAS 20452986 2282979 In this study we tested if activation of [ERK] and cPLA(2) occurred as a *result* of signaling during infection and determined the relative contribution of these signaling components to chlamydial replication and survival . Positive_regulation EPHB2 NRAS 21330403 2420299 Measurements of the dephosphorylation of [ERK] and the *activation* of showed that the ROS scavenger prevents the cAMP provoked activation of Ras and that cAMP , with or without a ROS scavenger , has little or no effect on the dephosphorylation of ERK . Positive_regulation EPHB2 NRAS 21678474 2483651 Furthermore , we demonstrate the mechanism for PLD1 activation of [ERK] *involves* . Positive_regulation EPHB2 NRAS 21949793 2488011 Like costimulation via CD28 , active *induced* AKT , JNK and [ERK] phosphorylation . Positive_regulation EPHB2 NRAS 22592532 2614452 To do so , we determined the role of CaMKII in Raf-1 and [ERK] *activation* by oncogenic and other factors . Positive_regulation EPHB2 NRAS 22592532 2614456 Serum , fibronectin , Src ( Y527 ) and ( V12 ) *activated* CaMKII and [ERK] , at different extents . Positive_regulation EPHB2 NRAS 22975374 2673978 Without EGFR activity , active levels are not *sufficient* to induce robust [MEK/ERK] activity , a requirement for epithelial transformation . Positive_regulation EPHB2 NRAS 23893412 2839580 The first step of *dependent* activation of [ERK] signaling is Ras binding to members of the Raf family of MAP kinase kinase kinases , C-Raf and B-Raf . Positive_regulation EPHB2 NRAS 23893412 2839597 Both B-Raf and C-Raf were constitutively bound to oncogenic Ras and contributed to dependent [ERK] *activation* . Positive_regulation EPHB2 NRAS 23893412 2839603 cAMP inhibited the growth of H1299 cells and *dependent* [ERK] activation via PKA . Positive_regulation EPHB2 NRAS 24327733 2880371 Unexpectedly , we found that in PIK3CA mutant and HER2 amplified breast cancers sensitive to PI3K inhibitors , PI3K inhibition led to a rapid suppression of Rac1/p21 activated kinase (PAK)/protein kinase C-RAF ( C-RAF ) / protein kinase MEK ( MEK ) [/ERK] signaling that did not *involve* . Positive_regulation EPHB2 NRAS 24711380 2935546 It is known that Erbin inhibits *mediated* activation of the extracellular signal regulated kinase ( [ERK] ) by binding to Soc-2 suppressor of clear homolog ( Shoc2 ) . Positive_regulation EPHB2 NRAS 25002533 2952824 These data show that caveolin-1 is necessary for optimal KSR1 dependent [ERK] *activation* by growth factors and oncogenic . Positive_regulation EPHB2 NRAS 9309148 454739 Treatment of fibroblast cells with this compound had very little effect on mediated *activation* of [ERK] and Jun kinase activities . Positive_regulation EPHB2 NRAS 9399643 469206 Treatment of fibroblast cells with this compound had very little effect on mediated *activation* of [ERK] and JUN kinase activities . Positive_regulation EPHB2 NRAS 9407076 470811 We have shown previously that *stimulated* [ERK] activation is essential for the induction and continued G1 expression of cyclin D1 . Positive_regulation EPHB2 NRAS 9632795 513079 These observations suggest that Gab1 acts as an adapter molecule in transmitting signals to ERK MAP kinase for the cytokine receptor gp130 and that SHP-2 , PI-3 kinase , and are *involved* in Gab1 mediated [ERK] activation . Positive_regulation EPHB2 NRAS 9774335 539660 Surprisingly , activation of endogenous Rap1 fails to affect dependent [ERK] *activation* . Positive_regulation EPHB2 NRAS 9892010 586558 We show that the activation of [ERK] via SSTR1 is pertussis toxin sensitive and *requires* the small G protein , phosphatidylinositol 3-kinase , the serine/threonine kinase Raf-1 , and the protein tyrosine phosphatase SHP-2 . Positive_regulation EPHB2 NRG1 12043846 895140 N-acetylcysteine , a ROS scavenger , inhibited induced *activation* of Ras and [Erk] and PC12-ErbB-4 cell differentiation . Positive_regulation EPHB2 NRG1 12716924 1083793 Disruption of lipid rafts inhibited *induced* activation of [Erk] and prevented NRG induced blockade of induction of long-term potentiation at hippocampal CA1 synapses . Positive_regulation EPHB2 NRG1 15691714 1371255 Moreover , *induced* [Erk] activation and AChR expression were attenuated when ErbB endocytosis was blocked . Positive_regulation EPHB2 NRG1 16301319 1511031 Moreover , Erbin-shRNA , which suppressed Erbin expression at mRNA and protein levels , increased the interaction of Sur-8 with Ras and Raf , [ERK] *activation* , and induced expression of endogenous acetylcholine receptor epsilon-subunit mRNA . Positive_regulation EPHB2 NRG1 16470843 1528268 Cyclic AMP synergistically enhances *dependent* [ERK] and Akt activation and cell cycle progression in Schwann cells . Positive_regulation EPHB2 NRG1 17085783 1643741 *induces* prolonged activation of PKB/Akt and [Erk] . Positive_regulation EPHB2 NRG1 17250808 1690959 Remarkably , inhibition of ErbB endocytosis attenuates induced *activation* of [Erk] and Akt in neurons . Positive_regulation EPHB2 NRG1 21898395 2554624 After ErbB4 cleavage , the *activation* of [ERK] by was almost completely inhibited . Positive_regulation EPHB2 NRG1 22496574 2583685 These changes are associated with rapid membrane expansion yielding a 35-50 % increase in SC size within 30 min. Cofilin1-deficient SCs increase phosphorylation of ErbB2 , [ERK] , focal adhesion kinase , and paxillin in *response* to , but fail to increase in size possibly due to stabilization of unusually long focal adhesions . Positive_regulation EPHB2 NRG2 12043846 895141 N-acetylcysteine , a ROS scavenger , inhibited *induced* activation of Ras and [Erk] and PC12-ErbB-4 cell differentiation . Positive_regulation EPHB2 NRG2 12716924 1083794 Disruption of lipid rafts inhibited induced *activation* of [Erk] and prevented NRG induced blockade of induction of long-term potentiation at hippocampal CA1 synapses . Positive_regulation EPHB2 NRG2 15691714 1371256 Moreover , induced [Erk] *activation* and AChR expression were attenuated when ErbB endocytosis was blocked . Positive_regulation EPHB2 NRG2 16301319 1511032 Moreover , Erbin-shRNA , which suppressed Erbin expression at mRNA and protein levels , increased the interaction of Sur-8 with Ras and Raf , [ERK] *activation* , and induced expression of endogenous acetylcholine receptor epsilon-subunit mRNA . Positive_regulation EPHB2 NRG2 16470843 1528269 Cyclic AMP synergistically enhances *dependent* [ERK] and Akt activation and cell cycle progression in Schwann cells . Positive_regulation EPHB2 NRG2 17085783 1643742 *induces* prolonged activation of PKB/Akt and [Erk] . Positive_regulation EPHB2 NRG3 12043846 895142 N-acetylcysteine , a ROS scavenger , inhibited induced *activation* of Ras and [Erk] and PC12-ErbB-4 cell differentiation . Positive_regulation EPHB2 NRG3 12716924 1083795 Disruption of lipid rafts inhibited *induced* activation of [Erk] and prevented NRG induced blockade of induction of long-term potentiation at hippocampal CA1 synapses . Positive_regulation EPHB2 NRG3 15691714 1371257 Moreover , *induced* [Erk] activation and AChR expression were attenuated when ErbB endocytosis was blocked . Positive_regulation EPHB2 NRG3 16301319 1511033 Moreover , Erbin-shRNA , which suppressed Erbin expression at mRNA and protein levels , increased the interaction of Sur-8 with Ras and Raf , [ERK] *activation* , and induced expression of endogenous acetylcholine receptor epsilon-subunit mRNA . Positive_regulation EPHB2 NRG3 16470843 1528270 Cyclic AMP synergistically enhances *dependent* [ERK] and Akt activation and cell cycle progression in Schwann cells . Positive_regulation EPHB2 NRG3 17085783 1643743 *induces* prolonged activation of PKB/Akt and [Erk] . Positive_regulation EPHB2 NRG4 12043846 895139 N-acetylcysteine , a ROS scavenger , inhibited *induced* activation of Ras and [Erk] and PC12-ErbB-4 cell differentiation . Positive_regulation EPHB2 NRG4 12716924 1083792 Disruption of lipid rafts inhibited induced *activation* of [Erk] and prevented NRG induced blockade of induction of long-term potentiation at hippocampal CA1 synapses . Positive_regulation EPHB2 NRG4 15691714 1371254 Moreover , *induced* [Erk] activation and AChR expression were attenuated when ErbB endocytosis was blocked . Positive_regulation EPHB2 NRG4 16301319 1511030 Moreover , Erbin-shRNA , which suppressed Erbin expression at mRNA and protein levels , increased the interaction of Sur-8 with Ras and Raf , [ERK] *activation* , and induced expression of endogenous acetylcholine receptor epsilon-subunit mRNA . Positive_regulation EPHB2 NRG4 16470843 1528267 Cyclic AMP synergistically enhances *dependent* [ERK] and Akt activation and cell cycle progression in Schwann cells . Positive_regulation EPHB2 NRG4 17085783 1643740 *induces* prolonged activation of PKB/Akt and [Erk] . Positive_regulation EPHB2 NRP2 18307536 1885935 Our studies suggest that IL-8 might be a malignant factor in human pancreatic cancer by induction of vascular endothelial growth factor and expression and [ERK] *activation* . Positive_regulation EPHB2 NSD1 15150258 1252308 Depolarization stimulated prolonged [ERK] and JNK activation that was *blocked* by the CaMKK inhibitor , ; Positive_regulation EPHB2 NSD1 15689566 1371127 Both the pharmacological inhibitor of CaMKK , , and dominant negative CaMKI ( dnCaMKI ) , a downstream target of CaMKK , *blocked* neuronal NMDA receptor dependent [ERK] activation . Positive_regulation EPHB2 NTF3 12595244 1061195 Dominant negative Ras , but not Rap , blocks induced [ERK] *activation* and VR1 upregulation . Positive_regulation EPHB2 NTF3 12595244 1061203 However , this may at least in part be due to a block of *induced* [ERK] activation . Positive_regulation EPHB2 NTF3 17202467 1681074 These results suggest that DISC1 is required for *induced* axon elongation and [ERK] activation at the distal part of axons by recruiting Grb2 to axonal tips . Positive_regulation EPHB2 NTF3 20427667 2247240 Altogether , we uncover a new role for FLIP-L as an unexpected critical player in *induced* mitogen activated protein [kinase/ERK-] and NF-kappaB mediated control of neurite growth in developing neurons . Positive_regulation EPHB2 NTF3 21411748 2432084 We show that Trk induced ADAM17 phosphorylation and generation of the p75NTR ( ICD ) is required for *induced* [Erk] and Akt activation and for neurotrophin dependent survival signaling . Positive_regulation EPHB2 NTF4 10486198 644704 BDNF , NT-3 , and *caused* rapid tyrosine phosphorylation of [ERK] and SNT . Positive_regulation EPHB2 NTF4 12595244 1061196 Dominant negative Ras , but not Rap , blocks *induced* [ERK] activation and VR1 upregulation . Positive_regulation EPHB2 NTF4 12595244 1061204 However , this may at least in part be due to a block of induced [ERK] *activation* . Positive_regulation EPHB2 NTF4 20427667 2247241 Altogether , we uncover a new role for FLIP-L as an unexpected critical player in *induced* mitogen activated protein [kinase/ERK-] and NF-kappaB mediated control of neurite growth in developing neurons . Positive_regulation EPHB2 NTF4 21411748 2432085 We show that Trk induced ADAM17 phosphorylation and generation of the p75NTR ( ICD ) is required for *induced* [Erk] and Akt activation and for neurotrophin dependent survival signaling . Positive_regulation EPHB2 NTN1 15811950 1392210 Moreover , this raft localization of DCC is required for induced DCC dependent [ERK] *activation* , and netrin-1 mediated axon outgrowth requires lipid raft integrity . Positive_regulation EPHB2 NTN1 19211685 2049936 *increased* the phosphorylation of Akt and [ERK] . Positive_regulation EPHB2 NTRK1 12237305 1012377 AEA thus inhibited *induced* [Rap1/B-Raf/ERK] activation . Positive_regulation EPHB2 NTRK1 18299325 1903870 Importantly , proNGF activates tyrosine phosphorylation , *induces* [Erk] and Akt activation , and causes PC12 cell differentiation . Positive_regulation EPHB2 NTRK1 18502403 1928168 It also requires *dependent* PI3K and [MAPK/Erk] signaling pathways because PDNF stimulation of cholinergic transcripts is abolished by specific pharmacological inhibitors . Positive_regulation EPHB2 NTRK1 24006492 2856248 Of interest , although both phosphoinositide 3-kinase-Akt and [Erk] signaling are *activated* by , NGF induced Akt-phosphorylation appears to be more sensitively affected by perturbed endosomal pH . Positive_regulation EPHB2 NTRK1 24530412 2924283 It is noteworthy that a inhibitor , K252a , an MEK-ERK inhibitor ( U0126 ) , and a PI3Kinase-Akt inhibitor ( LY294002 ) remarkably *attenuated* TrkB , [ERK] , and Akt phosphorylation as well as increase of OPN mRNA expression in the HCEM cells , respectively . Positive_regulation EPHB2 NTRK1 9292513 452786 NGF stimulation of HMC-1 cells induced tyrosine phosphorylation of protein , *increased* expression of the early response genes c-fos and NGF1-A , and activation of [ERK-mitogen] activated protein (MAP) kinase , results which indicate that TrkA receptors in HMC-1 cells are fully functional . Positive_regulation EPHB2 NTRK2 12504600 1026940 These data suggest that BDNF , once released with activity from primary afferent nociceptors , exerts a neuromodulatory role in pain processing through stimulation of postsynaptic receptors and subsequent *activation* of [ERK] . Positive_regulation EPHB2 NTRK2 19359495 2074545 Induction of corticospinal regeneration by lentiviral *induced* [Erk] activation . Positive_regulation EPHB2 NTRK2 20156366 2214775 In addition , the increased Pyk2 and [ERK] activities induced by BDNF were significantly *inhibited* by blocking expression , so was the invasion of A549 cells . Positive_regulation EPHB2 NUCB2 22514047 2613347 Reduction in expression *inhibited* EGF stimulated MAPK kinase ( S217/S221 ) and [Erk] phosphorylation ( T202/Y204 ) . Positive_regulation EPHB2 NUP153 21059916 2349514 Exposure to these exosomes *activated* the [ERK] and AKT signaling pathways in the recipient cells . Positive_regulation EPHB2 NUP210 21059916 2349513 Exposure to these exosomes *activated* the [ERK] and AKT signaling pathways in the recipient cells . Positive_regulation EPHB2 NUP214 21059916 2349515 Exposure to these exosomes *activated* the [ERK] and AKT signaling pathways in the recipient cells . Positive_regulation EPHB2 NUP62 21059916 2349516 Exposure to these exosomes *activated* the [ERK] and AKT signaling pathways in the recipient cells . Positive_regulation EPHB2 OAT 23707617 2806322 While major urate transporter URAT1 is not expressed in ß cells , inhibitor successfully *blocked* the activation of [ERK] by uric acid . Positive_regulation EPHB2 OMP 18565136 1972078 The *stimulated* phosphorylation of [ERK] in HGEC . Positive_regulation EPHB2 OPRM1 11457825 850811 mediated [ERK] *activation* involves calmodulin dependent epidermal growth factor receptor transactivation . Positive_regulation EPHB2 OSM 15979922 1446490 treatment *induced* phosphorylation of [ERK] , and pretreatment with U0126 , a MEK inhibitor , prevented the OSM stimulated proliferation of hATSCs , suggesting that the MEK/ERK pathway is involved in the OSM induced proliferation . Positive_regulation EPHB2 OSM 15979922 1446493 Furthermore , OSM treatment elicited phosphorylation of STAT1 and STAT3 , and pretreatment with WHI-P131 specifically prevented the OSM induced phosphorylation of STAT1 , without affecting the *induced* phosphorylation of [ERK] and STAT3 . Positive_regulation EPHB2 OSM 17169599 1688022 These results suggest that *induces* secretion of SDF-1 through [ERK-] , but not VEGF- , dependent signaling pathways in mesenchymal stem cells . Positive_regulation EPHB2 OSM 17226768 1771579 treatment *induced* activation of JAK2 , JAK3 , and [ERK] in hADSCs , and pre-treatment of hADSCs with the JAK2 inhibitor , AG490 , significantly restored the OSM induced inhibition of adipogenic differentiation . Positive_regulation EPHB2 OXA1L 12582006 1084898 Both LC and *activated* [ERK] , although the HSA effect was weaker . Positive_regulation EPHB2 OXT 22615888 2603939 Still other pathways could include MEK , but without subsequent activation of ERK , as we did not observe any increase in *induced* [ERK] phosphorylation . Positive_regulation EPHB2 P2RX1 11798872 892552 To investigate the mechanism of the activation of signal transduction of [ERK] *induced* by agonist ATP in prostate cancer cells with different metastatic potential . Positive_regulation EPHB2 P2RX3 16616417 1569011 Thus , it is suggested that the activation of the receptor is *involved* in the phosphorylation of [ERK] in DRG neurons and the mechanical hypersensitivity of the inflamed knee joint . Positive_regulation EPHB2 P2RX6 17490650 1766630 These studies indicate that injury induced activation *leads* to phosphorylation of EGFR , [ERK] and migration . Positive_regulation EPHB2 P2RX7 15075366 1251803 We observed that the P2X7 agonists adenosine 5'-triphosphate ( ATP ) and 3'-O- ( 4-benzoylbenzoyl ) ATP ( BzATP ) stimulated actin reorganization and concomitant membrane blebbing within 5 min. Disruption of actin filaments with cytochalasin D attenuated membrane blebbing but not dependent pore formation or [extracellular regulated kinase (ERK)1/ERK2] and p38 *activation* , suggesting that these latter processes do not require intact actin filaments . Positive_regulation EPHB2 P2RX7 17474086 1772244 receptor stimulation *upregulates* Egr-1 biosynthesis involving a cytosolic Ca ( 2+ ) rise , transactivation of the EGF receptor and phosphorylation of [ERK] and Elk-1 . Positive_regulation EPHB2 P2RY12 18042400 1846623 Notably , *mediated* agonist induced [ERK] phosphorylation only when it was expressed at low levels on the cell surface , highlighting the utility of regulated expression for the production of functionally active GPCRs in mammalian cells . Positive_regulation EPHB2 PABPC1 19304659 2073389 Mechanism of sustained *activation* of ribosomal S6 kinase ( RSK ) and [ERK] by kaposi sarcoma associated herpesvirus ORF45 : complexes retain active phosphorylated ERK AND RSK and protect them from dephosphorylation . Positive_regulation EPHB2 PABPC1 19319189 2052425 GTP-Raf-MEK-ERK to *promote* sustained [ERK] activation and regulate H-Ras dependent neuritogenesis . Positive_regulation EPHB2 PAF1 11934880 953471 In contrast , these inhibitors almost completely blocked both *induced* [ERK] phosphorylation and LTC ( 4 ) generation in PAFR cells . Positive_regulation EPHB2 PAF1 11934880 953476 However , in mPAFR cells pertussis toxin only partially inhibited *induced* [ERK] phosphorylation . Positive_regulation EPHB2 PAF1 11934880 953481 A Ca ( 2+ ) /calmodulin inhibitor had no effect on *induced* [ERK] phosphorylation in PAFR cells but completely blocked the response in mPAFR cells . Positive_regulation EPHB2 PAF1 12687020 1078714 *activated* three prominent mitogen activated protein kinase modules ( [ERK] , p38MAPK and Jun N-terminal kinases ) in these cells , inhibited proliferation and induced differentiation ( measured by the induction of Waf1/p21 and the induction of the differentiation related marker CEA ) . Positive_regulation EPHB2 PAF1 15115659 1241552 These results indicate that *induced* activation of [ERK] contributes to both the expression of the pro-adhesive phenotype and repression of neutrophil apoptosis , thereby amplifying the inflammatory response . Positive_regulation EPHB2 PAF1 15917990 1413202 *induced* [ERK] phosphorylation is mediated by PI3K , PKC , PLA2 , PLC , and extracellular calcium , whereas fMLP induced ERK phosphorylation does not involve the PKC-gamma isoform and extracellular calcium . Positive_regulation EPHB2 PAF1 20074623 2218624 These results suggest that *induces* synaptic facilitation through activation of CaMKII , PKC and [ERK] in the hippocampal CA1 region . Positive_regulation EPHB2 PAF1 23911909 2840516 Likewise , ERK phosphorylation was markedly enhanced in PAF stimulated VSMCs , and this was attenuated by WEB2086 , but not by EGF receptor inhibitor , demonstrating the specificity of PAF receptor (PAFR) in *induced* [ERK] phosphorylation . Positive_regulation EPHB2 PAF1 23911909 2840522 In addition , *induced* [ERK] phosphorylation and MMP-2 production were significantly attenuated by ß-arrestin2 depletion . Positive_regulation EPHB2 PAF1 9878562 557851 Stimulation of receptor *induces* activation of extracellular signal regulated kinase ( [ERK] ) and cytosolic phospholipase A2 (cPLA2) and release of arachidonic acid in Chinese hamster ovary cells . Positive_regulation EPHB2 PAF1 9915820 587190 The *induced* p38 and [ERK] pathways appeared to be preferentially regulated by RGS16 and RGS1 , respectively . Positive_regulation EPHB2 PAIP1 19304659 2073386 Mechanism of sustained *activation* of ribosomal S6 kinase ( RSK ) and [ERK] by kaposi sarcoma associated herpesvirus ORF45 : complexes retain active phosphorylated ERK AND RSK and protect them from dephosphorylation . Positive_regulation EPHB2 PAIP1 19319189 2052415 GTP-Raf-MEK-ERK to *promote* sustained [ERK] activation and regulate H-Ras dependent neuritogenesis . Positive_regulation EPHB2 PAK1 12511425 1070746 PAK1 ( p21 activated kinase 1 ) activation is induced by C albicans , suggesting that may also be *involved* in the Rac1 activation of [MAPK/ERK] . Positive_regulation EPHB2 PAK1 12546821 1051199 Activation of the [EphB] receptor *induces* translocation of the Rho-GEF kalirin to synapses and activation of Rac1 and its effector . Positive_regulation EPHB2 PAK1 15542607 1360708 Interestingly , deletion of a major ERK binding site in PAK attenuates activation of an ERK dependent serum-responsive element ( SRE ) -luciferase reporter gene , indicating that association between and ERK is *required* to facilitate [ERK] signaling . Positive_regulation EPHB2 PAK1 21072183 2345048 However , in tumors , loss of activity does not *reduce* [Erk] or Akt activity , two signaling proteins that are thought to mediate Pak function in growth factor pathways . Positive_regulation EPHB2 PAK1 22981863 2688687 LAT independent [Erk] *activation* via complexes : GTPase independent Pak1 activation . Positive_regulation EPHB2 PAK2 12546821 1051200 Activation of the [EphB] receptor *induces* translocation of the Rho-GEF kalirin to synapses and activation of Rac1 and its effector . Positive_regulation EPHB2 PAK2 15542607 1360709 Interestingly , deletion of a major ERK binding site in PAK attenuates activation of an ERK dependent serum-responsive element ( SRE ) -luciferase reporter gene , indicating that association between and ERK is *required* to facilitate [ERK] signaling . Positive_regulation EPHB2 PAK2 17440079 1729379 Moreover , although the initial activation of Ras and PAK2 are distinctly regulated , TGF-beta stimulated activity is *required* for Ras dependent [ERK] phosphorylation and Elk-1 transcription . Positive_regulation EPHB2 PAK2 21072183 2345049 However , in tumors , loss of activity does not *reduce* [Erk] or Akt activity , two signaling proteins that are thought to mediate Pak function in growth factor pathways . Positive_regulation EPHB2 PAK3 12546821 1051201 Activation of the [EphB] receptor *induces* translocation of the Rho-GEF kalirin to synapses and activation of Rac1 and its effector . Positive_regulation EPHB2 PAK3 15542607 1360710 Interestingly , deletion of a major ERK binding site in PAK attenuates activation of an ERK dependent serum-responsive element ( SRE ) -luciferase reporter gene , indicating that association between and ERK is *required* to facilitate [ERK] signaling . Positive_regulation EPHB2 PAK3 21072183 2345050 However , in tumors , loss of activity does not *reduce* [Erk] or Akt activity , two signaling proteins that are thought to mediate Pak function in growth factor pathways . Positive_regulation EPHB2 PAK4 12546821 1051197 Activation of the [EphB] receptor *induces* translocation of the Rho-GEF kalirin to synapses and activation of Rac1 and its effector . Positive_regulation EPHB2 PAK4 15542607 1360706 Interestingly , deletion of a major ERK binding site in PAK attenuates activation of an ERK dependent serum-responsive element ( SRE ) -luciferase reporter gene , indicating that association between and ERK is *required* to facilitate [ERK] signaling . Positive_regulation EPHB2 PAK4 21072183 2345046 However , in tumors , loss of activity does not *reduce* [Erk] or Akt activity , two signaling proteins that are thought to mediate Pak function in growth factor pathways . Positive_regulation EPHB2 PAK6 12546821 1051198 Activation of the [EphB] receptor *induces* translocation of the Rho-GEF kalirin to synapses and activation of Rac1 and its effector . Positive_regulation EPHB2 PAK6 15542607 1360707 Interestingly , deletion of a major ERK binding site in PAK attenuates activation of an ERK dependent serum-responsive element ( SRE ) -luciferase reporter gene , indicating that association between and ERK is *required* to facilitate [ERK] signaling . Positive_regulation EPHB2 PAK6 21072183 2345047 However , in tumors , loss of activity does not *reduce* [Erk] or Akt activity , two signaling proteins that are thought to mediate Pak function in growth factor pathways . Positive_regulation EPHB2 PAK7 12546821 1051196 Activation of the [EphB] receptor *induces* translocation of the Rho-GEF kalirin to synapses and activation of Rac1 and its effector . Positive_regulation EPHB2 PAK7 15542607 1360705 Interestingly , deletion of a major ERK binding site in PAK attenuates activation of an ERK dependent serum-responsive element ( SRE ) -luciferase reporter gene , indicating that association between and ERK is *required* to facilitate [ERK] signaling . Positive_regulation EPHB2 PAK7 21072183 2345045 However , in tumors , loss of activity does not *reduce* [Erk] or Akt activity , two signaling proteins that are thought to mediate Pak function in growth factor pathways . Positive_regulation EPHB2 PAM 17458858 1743188 Conversely , [ERK] activation in *response* to the TLR2 agonist is completely MyD88 dependent and unaffected by Syk deficiency . Positive_regulation EPHB2 PAM 18218857 1884126 We found that S. aureus and *stimulate* phosphorylation of JNK , p38 MAPK , and [ERK] within 4 h and that blockade of JNK , but not p38 or ERK phosphorylation , had an inhibitory effect on IkBalpha degradation and CXC chemokine production . Positive_regulation EPHB2 PAM 20497485 2339695 SP primed LTA and mediated *activation* of JNK , p38 and extracellular-signal regulated kinase ( [ERK] ) and activated the nuclear translocation of c-Jun , nuclear factor ( NF ) -?B , activating transcription factor 2 ( ATF-2 ) and cyclic-AMP-responsive element binding protein ( CREB ) transcription factors . Positive_regulation EPHB2 PAM 21454454 2432650 Using Meg-01 cells and mouse megakaryocytes , we found that NF?B , [ERK-MAPK] , and PI3K/Akt pathways , known downstream pathways of TLRs , are *activated* by , a TLR2-specific ligand . Positive_regulation EPHB2 PAM 22948158 2688108 , a specific TLR2 agonist , *stimulated* phosphorylation of JNK , [ERK] , and p38 , but only JNK and ERK inhibition blocked Pam3Cys stimulated chemotaxis . Positive_regulation EPHB2 PAM 24205328 2864797 Furthermore , GW843682X inhibited induced *activation* of [ERK] and NF-?B , which contributed to Pam3CSK4 induced up-regulation of TNF-a . Positive_regulation EPHB2 PARP1 11146560 760889 We provide evidence that mutants *promote* [ERK] activation and that the active protein induces a more sustained activation than the inactive protein . Positive_regulation EPHB2 PARP1 11228165 788434 is *involved* in cell stretching modulation of p38 but not [ERK] or JNK MAP kinase . Positive_regulation EPHB2 PARP1 11479306 860641 Moreover , inhibition of by a Rap1 GTPase activating protein-1 also *resulted* in a decrease in [ERK] and Akt phosphorylation , which was not further decreased by cAMP , suggesting that cAMP inhibits ERK and Akt by inhibiting Rap1 . Positive_regulation EPHB2 PARP1 11479306 860697 The *role* of in [ERK] and Akt activity was further demonstrated by our observation that an active form of Epac , which activated Rap1 in the absence of cAMP , increased ERK and Akt phosphorylation . Positive_regulation EPHB2 PARP1 14551200 1175542 Experiments involving the expression of the dominant negative mutants of Ras and Rap1 signaling ( RasN17 or Rap1N17 ) indicate that both GTPases Ras and Rap1 are recruited for the ERK activation by VIP and PACAP38 , whereas is poorly *involved* in TRH or EGF induced [ERK] activation . Positive_regulation EPHB2 PARP1 14607972 1162185 Functionally , either interferes with Ras mediated ERK activation or *activates* [ERK] independently of Ras in a cell-context dependent manner . Positive_regulation EPHB2 PARP1 16152590 1517351 Bcl-2 phosphorylation and *activation* of [ERK] and JNK and caspase 3-dependent cleavage of were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation EPHB2 PARP1 16507992 1529681 We confirm that the PKA independent activation of by Epac1 activates a perinuclear pool of Rap1 and that this does not *result* in [ERK] activation . Positive_regulation EPHB2 PARP1 16648609 1553346 Furthermore , the antioxidant N-acetyl-L-cysteine effectively blocked ajoene mediated ROS generation , *activation* of JNK and [ERK] , translocation of AIF , and degradation of . Positive_regulation EPHB2 PARP1 17472964 1750448 Moreover , Ca2+ induced *activation* of [ERK] through and expression of loricrin were reduced in primary cultured nectin-1-/- keratinocytes ; Positive_regulation EPHB2 PARP1 21635224 2464509 Furthermore , activated *up-regulated* the activity of phosphorylated [ERK] ( extracellular-signal regulated kinase ) in the nucleus , promoting expression of the Elk1 target gene c-fos . Positive_regulation EPHB2 PARP10 16152590 1517346 Bcl-2 phosphorylation and *activation* of [ERK] and JNK and caspase 3-dependent cleavage of were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation EPHB2 PARP11 16152590 1517343 Bcl-2 phosphorylation and *activation* of [ERK] and JNK and caspase 3-dependent cleavage of were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation EPHB2 PARP12 16152590 1517344 Bcl-2 phosphorylation and *activation* of [ERK] and JNK and caspase 3-dependent cleavage of were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation EPHB2 PARP14 16152590 1517355 Bcl-2 phosphorylation and *activation* of [ERK] and JNK and caspase 3-dependent cleavage of were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation EPHB2 PARP15 16152590 1517349 Bcl-2 phosphorylation and *activation* of [ERK] and JNK and caspase 3-dependent cleavage of were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation EPHB2 PARP16 16152590 1517347 Bcl-2 phosphorylation and *activation* of [ERK] and JNK and caspase 3-dependent cleavage of were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation EPHB2 PARP2 16152590 1517353 Bcl-2 phosphorylation and *activation* of [ERK] and JNK and caspase 3-dependent cleavage of were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation EPHB2 PARP3 16152590 1517354 Bcl-2 phosphorylation and *activation* of [ERK] and JNK and caspase 3-dependent cleavage of were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation EPHB2 PARP4 16152590 1517352 Bcl-2 phosphorylation and *activation* of [ERK] and JNK and caspase 3-dependent cleavage of were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation EPHB2 PARP6 16152590 1517350 Bcl-2 phosphorylation and *activation* of [ERK] and JNK and caspase 3-dependent cleavage of were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation EPHB2 PARP8 16152590 1517348 Bcl-2 phosphorylation and *activation* of [ERK] and JNK and caspase 3-dependent cleavage of were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation EPHB2 PARP9 16152590 1517345 Bcl-2 phosphorylation and *activation* of [ERK] and JNK and caspase 3-dependent cleavage of were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation EPHB2 PAX6 12586435 1059076 Furthermore , transfection of into undifferentiated P19 cells *up-regulated* [EphB2] . Positive_regulation EPHB2 PBK 22314276 2571463 SPK1 mediated activation of the PI3K-AKT-ß-catenin pathway is essential for ATX induction , while *mediated* [ERK] activation is required for LPA ( 3 ) up-regulation . Positive_regulation EPHB2 PCK1 16550001 1537918 We found that bound to the HT-1080 cell surface and that this binding rapidly *triggered* [ERK] phosphorylation that , ultimately , led to a reduction of secreted MMP-9 . Positive_regulation EPHB2 PCK2 16550001 1537919 We found that bound to the HT-1080 cell surface and that this binding rapidly *triggered* [ERK] phosphorylation that , ultimately , led to a reduction of secreted MMP-9 . Positive_regulation EPHB2 PCNA 22609943 2609767 , which maintains Cdk1 activity , *caused* [ERK] activity in the eggs to persist for over 120 min after fertilization , and prolonged [ Ca ( 2+ ) ] ( i ) oscillations . Positive_regulation EPHB2 PDE4D 20819076 2336435 Interaction with RACK1 was also essential for PKC dependent and [ERK] ( extracellular-signal regulated kinase ) -independent phosphorylation ( on Ser¹²6 ) , and *activation* of in response to PMA and isoproterenol , both of which trigger the recruitment of PKCa to RACK1 . Positive_regulation EPHB2 PDGFB 10455028 638398 TGF-beta(1) had no inhibitory effect on [ERK] activation *induced* by or bFGF . Positive_regulation EPHB2 PDGFB 10898734 712116 Phosphorylation of PKB-alpha and [ERK] *induced* by was maximal within 5-15 min in A7r5 cells . Positive_regulation EPHB2 PDGFB 12012331 941608 Selective antagonism of ERK kinase inhibited *induced* [ERK] phosphorylation and proliferation , but did not affect PDGF-BB stimulated migration . Positive_regulation EPHB2 PDGFB 12705352 1082451 Activation of PI 3-kinase was not required for *induced* [ERK] activation . Positive_regulation EPHB2 PDGFB 12782622 1113493 However , FRNK expression did not alter the magnitude or dynamics of [ERK] activation *induced* by or angiotensin II . Positive_regulation EPHB2 PDGFB 14755552 1205829 *enhanced* not only gel contraction but [ERK] phosphorylation and AP-1 activity by MCs . Positive_regulation EPHB2 PDGFB 14755552 1205831 Marked inhibitory effects on *induced* gel contraction and [ERK/AP-1] activity were observed in the presence of either function blocking anti-alpha1- or anti-beta1-integrin antibody or U0126 . Positive_regulation EPHB2 PDGFB 15625285 1369411 In the presence of bFGF antibody , *induced* early activation of [ERK] ( 0 to 60 minutes ) was not affected , whereas late ERK activation ( 2 to 4 hours ) was reduced . Positive_regulation EPHB2 PDGFB 15753096 1396970 This was accompanied by rapid uptake of receptor bound into the cells and by attenuated [ERK] *activation* in response to PDGF-BB stimulation . Positive_regulation EPHB2 PDGFB 15948243 1421107 *induced* STAT-specific binding activity , and activation of Src , JAK2 , STAT1 , STAT3 , and [ERK] . Positive_regulation EPHB2 PDGFB 16294327 1532382 Curcumin inhibited *induced* cyclin D1 expression and activation of extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 PDGFB 19339244 2080742 Knockdown of FRS2 in VSMC by RNA interference inhibited PDGF-BB mediated down-regulation of SMA and SM22alpha without affecting *mediated* cell proliferation or [ERK] activation . Positive_regulation EPHB2 PDGFB 20070402 2235210 Western blot analysis showed that BB-PAC completely or partially inhibited *induced* [ERK] and Akt phosphorylation , respectively . Positive_regulation EPHB2 PDGFB 20526801 2320128 Herein we demonstrate that treatment of MB cells *induces* concomitant activation of PDGFRß , [MEK1/ERK] , Rac1 and Pak1 , but suppresses Rho activity , which together significantly promotes cell migration . Positive_regulation EPHB2 PDGFB 22815499 2629066 Blocking TRPC1 channel suppressed PDGF mediated proliferation as well as *induced* [ERK/CREB] and mTOR/4E-BP-p70S6K activation , thereby underscoring its role in this process . Positive_regulation EPHB2 PDGFB 22972916 2719959 Treatment of VSMCs with CTRP9 protein attenuated the proliferative and chemotactic activities induced by growth factors including platelet derived growth factor (PDGF)-BB , and suppressed *stimulated* phosphorylation of [ERK] . Positive_regulation EPHB2 PDGFB 22972916 2719960 Blockade of cAMP-PKA pathway reversed the inhibitory effect of CTRP9 on DNA synthesis and [ERK] phosphorylation in *response* to . Positive_regulation EPHB2 PDGFB 24309234 2899258 Furthermore , *stimulated* [ERK] activation was significantly inhibited by CPS-2 , and this inhibitory effect was synergistically potentiated by U0126 . Positive_regulation EPHB2 PDGFB 9683541 521439 Western analysis confirmed that [ERK] was strongly *activated* by and PMA but not by IGF-I . Positive_regulation EPHB2 PDGFC 19795151 2209074 PDGF receptor alpha and PDGF receptor beta inhibition prevented *induced* [ERK] phosphorylation . Positive_regulation EPHB2 PDGFD 22415093 2567205 *activated* Akt and [ERK] in both the non-malignant and malignant cells . Positive_regulation EPHB2 PDGFRA 14647422 1210465 In transient transfection experiments , we demonstrate that IFNalpha inhibits [Erk] phosphorylation and serum response element activation *induced* by expression of SMO , Gli1 , and activated Raf , but not activated mitogen activated Erk regulating kinase ( Mek ) , suggesting that IFNalpha targets mainly on Mek function . Positive_regulation EPHB2 PDGFRB 14657000 1202014 In addition , S1P stimulated activation of Akt , but not [ERK] , was *blocked* by a inhibitor , AG1296 , suggesting a S1P3 mediated specific crosstalk between the Akt signaling pathways of S1P and PDGFR in MEFs . Positive_regulation EPHB2 PDGFRB 14657000 1202029 We investigated this crosstalk under different conditions and found that both Akt and [ERK] activation induced by S1P , but not lysophosphatidic acid (LPA) , in HEY ovarian cancer cells *required* but not epidermal growth factor receptor (EGFR) or insulin-like growth factor-I receptor ( IGFR ) . Positive_regulation EPHB2 PDGFRB 9671791 520029 The cross-talk appears to be cell type-specific : In L cells that lack EGFR , lysophosphatidic acid induced Shc and [ERK] activation is *prevented* completely by specific inhibition of , whereas in COS-7 cells expressing only EGFR , the pathway via EGFR is chosen . Positive_regulation EPHB2 PDLIM7 16002423 1465453 *mediated* [SAP/ERK/IFN-gamma] signals appear to act via the TNF receptor associated factor (TRAF)2,5/nuclear factor kappaB (NF-kappaB) pathway , since dominant negative TRAF2/5 and NF-kappaB inhibitor could rescue SAP expression and downregulate IFN-gamma . Positive_regulation EPHB2 PDLIM7 21307189 2414748 Epstein-Barr virus *activates* EGFR , STAT3 , and [ERK] through effects on PKCdelta . Positive_regulation EPHB2 PDLIM7 21307189 2414763 Interestingly , inhibition of PKCd also inhibited constitutive phosphorylation of EGFR and *induced* phosphorylation of [ERK] . Positive_regulation EPHB2 PDLIM7 21307189 2414764 These findings indicate that LMP1 activates multiple distinct signaling pathways and suggest that PKCd functions as a master regulator of EGFR , STAT3 , and [ERK] *activation* by . Positive_regulation EPHB2 PDLIM7 22396784 2566845 [ERK-specific] small interfering RNA blunts *induced* kappa light chain gene expression . Positive_regulation EPHB2 PDLIM7 22396784 2566846 PD98059 treatment also leads to a concentration dependent inhibition of LMP1 induced Ets-1 expression and phosphorylation , which corresponds with a dose dependent attenuation of *induced* [ERK] phosphorylation and kappa light chain expression . Positive_regulation EPHB2 PDLIM7 22417000 2606573 The inhibition of expression *attenuated* the interaction of [ERK] with Op18/stathmin and promoted microtubule depolymerization . Positive_regulation EPHB2 PDLIM7 22417000 2606574 These findings indicate the existence of a new cell cycle associated signaling pathway in which *regulates* [ERK] mediated Op18/stathmin signaling . Positive_regulation EPHB2 PDLIM7 23152522 2723079 Reduction of vimentin levels or disruption of its organization also decreased mediated Akt and [ERK] *activation* and inhibited transformation of rodent fibroblasts . Positive_regulation EPHB2 PDYN 11784793 901080 [ERK] MAP kinase activation in superficial spinal cord neurons *induces* and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity . Positive_regulation EPHB2 PEA15 10982386 731858 expression in Chinese hamster ovary cells *resulted* in an increased mitogen activated protein kinase kinase and [ERK] activity . Positive_regulation EPHB2 PEA15 11702783 878853 Genetic deletion of *results* in increased [ERK] nuclear localization with consequent increased cFos transcription and cell proliferation . Positive_regulation EPHB2 PEA15 16170361 1499902 *promotes* translocation of [ERK] from the nucleus to the cytoplasm , leading to inhibition of ERK dependent transcription and proliferation . Positive_regulation EPHB2 PEA15 17700518 1865977 *regulates* the level of phosphorylated [extracellular regulated kinase (ERK)1/2] in glioblastoma cells and the PEA-15 dependent protection from glucose deprivation induced cell death requires ERK1/2 signaling . Positive_regulation EPHB2 PEA15 20452983 2282976 The mechanism by which inhibits caspase activation and *increases* [ERK] ( extracellular regulated kinase ) activity is well characterized . Positive_regulation EPHB2 PEA15 22105357 2629385 Our findings reveal a novel mechanism by which positively *regulates* [Ras/ERK] signaling and increases the proliferation of H-Ras transformed epithelial cells through enhanced PLD1 expression and activation . Positive_regulation EPHB2 PEBP1 17000055 1647270 We propose that , following ischemia , the Src family tyrosine kinases are critical for modulation of the Ras/Raf/MEK/ERK cascade , in which is *involved* in biphasic phosphorylation of [ERK] via a blockade of Src-Raf cascades . Positive_regulation EPHB2 PEBP1 22492043 2583509 Collectively , our data reveal an important *role* of in the regulation of [MAPK/ERK] signaling in the SCN and photic entrainment of the SCN clock . Positive_regulation EPHB2 PECAM1 15502396 1327305 The osmotic-shock induced [ERK] activation but not p38 MAP kinase activation was *dependent* on the engagement and was blocked by its downregulation . Positive_regulation EPHB2 PF4 17675521 1777359 However , induced up-regulation of chemokine and cytokine mRNA and protein *requires* a sustained activation of JNK and [Erk] . Positive_regulation EPHB2 PFN1 22693641 2615624 Our findings reveal that ACE2 deficiency worsens Ang II-mediated aortic inflammation and peroxynitrite production associated with the augmentation of expression and the *activation* of the [Akt-ERK-eNOS] signaling , suggesting potential therapeutic approaches by enhancing ACE2 action for patients with vascular diseases . Positive_regulation EPHB2 PGF 10976990 729637 In contrast to their implication in epidermal growth factor (EGF) receptor tyrosine kinase signaling , the adaptor protein Shc , the Grb2/Sos complex , and the small G protein Ras were not involved in the activation of [Erk] *induced* by either LPA or in MC3T3-E1 cells , suggesting that activation of Erk by Gi and Gq protein coupled receptors is Ras independent in these cells . Positive_regulation EPHB2 PGF 11159862 781399 By using a PKC inhibitor and a PKC-deficient luteal cell model , we observed that phorbol ester-responsive isoforms of PKC were required for [ERK] phosphorylation and *activation* by ( 1 microM ) or phorbol 12-myristate 13-acetate ( PMA ) ( 20 nM ) . Positive_regulation EPHB2 PGF 11159862 781400 *induced* [ERK] phosphorylation was dose-dependently inhibited by the MEK1 inhibitor PD098059 ( 1-50 microM ) . Positive_regulation EPHB2 PGF 20124327 2202435 These findings suggest that aging does not affect the ability of the rat aorta to activate [ERK] ( 1/2 ) - , p38-MAPK , and JNK-MAPK phosphorylation in *response* to stimulation . Positive_regulation EPHB2 PGF 20536573 2271618 ( 2alpha ) *induced* both [ERK] and CREB/ATF-1 phosphorylation in pulp cells . Positive_regulation EPHB2 PGF 20551949 2285058 *stimulated* phosphorylation of [extracellular regulated kinase (ERK)1/2] ( pERK ) in breast cancer cell lines that also increased motility . Positive_regulation EPHB2 PGF 21191105 2391310 ( 2a ) *stimulated* time- and dose dependent increases in the phosphorylation of [extracellular receptor kinase (ERK)1/2] ( Thr202/Tyr204 ) , p70S6 kinase (p70S6K) ( Thr389 and Thr421/Ser424 ) , and eukaryotic initiation factor 4G (eIF4G) ( Ser1108 ) without influencing Akt ( Ser473 ) . Positive_regulation EPHB2 PGF 22967907 2710379 In the MH1C1 hepatocarcinoma cells , stimulation with PGE2 or *caused* phosphorylation of the EGFR , Akt , and [ERK] , which could be blocked by the EGFR tyrosine kinase inhibitor gefitinib . Positive_regulation EPHB2 PGR 20484412 2333976 Rapid *activation* of [Erk] by progestins via an interaction of the with the estrogen receptor is critical for transcriptional activation of the mouse mammary tumor virus ( MMTV ) promoter and other progesterone target genes . Positive_regulation EPHB2 PHB 16041367 1437719 is *required* for Ras induced [Raf-MEK-ERK] activation and epithelial cell migration . Positive_regulation EPHB2 PHKA2 10329689 613780 Expression of a Grb2 mutant with a deletion of the amino-terminal Src homology 3 domain or the carboxyl-terminal tail of Sos strongly reduced *induced* [ERK] activation , with no apparent effect on JNK activity . Positive_regulation EPHB2 PHKA2 10329689 613785 Grb2 with a deleted carboxyl-terminal Src homology 3 domain partially blocked *induced* [ERK] and JNK pathways , whereas expression of dominant interfering mutants of p130Cas or Crk specifically inhibited JNK but not ERK activation by Pyk2 . Positive_regulation EPHB2 PHKA2 11851354 913222 *Role* of EGF Receptor and in endothelin-1 induced [ERK] activation in rat cardiomyocytes . Positive_regulation EPHB2 PHKA2 18635666 1966661 Knockdown of Pyk2 using specific small interfering RNAs revealed that *contributed* to modulation of GnRH induced [ERK] but not c-Jun N-terminal kinase activation . Positive_regulation EPHB2 PI3 10537068 562977 These inhibitors also *inhibited* the activation of [ERK] in response to MK , demonstrating a link between ERK and the caspase-3 pathway that is modulated by the PI 3-kinase activation . Positive_regulation EPHB2 PI3 10688975 670351 Thus , these data suggest that activation of [ERK] by calcitonin gene related peptide *involves* a H89-sensitive protein kinase A and a wortmannin-sensitive while activation of p38 MAPK by calcitonin gene related peptide involves only the H89 sensitive pathway and is independent of PI3 kinase . Positive_regulation EPHB2 PI3 11062502 762661 We show that inhibition of in NK cells *blocks* p21 activated kinase 1 (PAK1) , MAPK kinase ( MEK ) and [ERK] activation by target cell ligation , interferes with perforin and granzyme B movement toward target cells and suppresses NK cytotoxicity . Positive_regulation EPHB2 PI3 11818455 908213 The WKYMVm induced [ERK] activation was *dependent* but PKC independent . Positive_regulation EPHB2 PI3 12055094 951671 Inhibition of phospholipase C (PLC) by U-73122 or of by wortmannin partially *reduced* [ERK] activation . Positive_regulation EPHB2 PI3 12138095 991539 Cell survival relied on two pertussis toxin-sensitive events , activation of [ERK] and *activation* of by S1P . Positive_regulation EPHB2 PI3 12502866 1033854 Examination of viral DNA entry suggests a *role* for in HHV-8 entry into the target cells and a role for PKC-zeta , MEK , and [ERK] at a post-viral entry stage of infection . Positive_regulation EPHB2 PI3 12532415 1048964 In contrast , inhibition of *blocked* the constitutive phosphorylation of [Erk] and AKT-1 but not the EGFR . Positive_regulation EPHB2 PI3 12594849 1061092 The association of phosphoinositide 3-kinase (PI-3K) to H4/ICOS was enhanced by H4/ICOS cross linking , and inhibitors *inhibited* [ERK] and JNK activation and IL-4/IL-10 secretion , but not p38 MAP kinase or ZAP-70 activation . Positive_regulation EPHB2 PI3 12657612 1073273 Fibronectin fragments promote human retinal endothelial cell adhesion and proliferation and [ERK] *activation* through alpha5beta1 integrin and . Positive_regulation EPHB2 PI3 12705352 1082452 Activation of was not *required* for PDGF-BB induced [ERK] activation . Positive_regulation EPHB2 PI3 14563359 1154812 Experiments based on inhibitors of specific signaling pathways , such as manumycin A , toxin A , U0126 , PD98059 and wortmannin revealed that Ras , MEK and are *involved* in the activation of [ERK] . Positive_regulation EPHB2 PI3 14563359 1154821 Whether is an intermediate of Ras/MEK/ERK pathway or *activates* [ERK] via other signaling pathway it remains to be elucidated . Positive_regulation EPHB2 PI3 14996702 1257038 Surprisingly , kinase inhibitors *block* not only PKB/Akt activation but also activation of Raf and [Erk] . Positive_regulation EPHB2 PI3 15919658 1433649 VEGF induced [Erk] activation was not *dependent* on activation but required sequential phosphorylation of type 2 VEGF receptor , PLCgamma and c-Src , as demonstrated by inhibitors SU1498 , U73122 , and PP1 , respectively . Positive_regulation EPHB2 PI3 15952178 1440638 The inhibitors LY294002 and wortmannin , and the MAPK/extracellular signal regulated kinase ( ERK ) kinase ( MEK ) inhibitors U0126 and PD98059 , reduced HB-EGF induced BrdU incorporation into cultures , and HB-EGF *enhanced* phosphorylation of Akt and [ERK] , implying a role for PI3K/Akt and MEK/ERK signaling in HB-EGF stimulated cell proliferation . Positive_regulation EPHB2 PI3 19879308 2196986 The administration of curcumin led to increased levels of [phosphor-ERK] and AKT , which were each *blocked* by MAPK and inhibitors . Positive_regulation EPHB2 PI3 24530412 2924284 It is noteworthy that a tyrosine kinase receptor inhibitor , K252a , an MEK-ERK inhibitor ( U0126 ) , and a inhibitor ( LY294002 ) remarkably *attenuated* TrkB , [ERK] , and Akt phosphorylation as well as increase of OPN mRNA expression in the HCEM cells , respectively . Positive_regulation EPHB2 PI3 8999998 410047 The constitutive activation of alone is *sufficient* to activate PKB/Akt , but not the MAP kinase [ERK] or the stress activated protein kinase , Jun N-terminal kinase . Positive_regulation EPHB2 PIGF 10068204 594087 In the first trimester trophoblast cells , PIGF-1 increased the association of phosphorylated extracellular signal related kinase ( ERK ) with VEGFR-1 immunoprecipitates while both and PIGF-2 also *potentiated* endogenous VEGF mediated association of phosphorylated [extracellular related kinase (ERK)] with VEGFR-2 ( KDR ) . Positive_regulation EPHB2 PIK3C3 11853873 913394 Additionally , Y(5) receptor mediated [ERK] phosphorylation was *inhibited* by the inhibitors LY294002 and wortmannin to a greater extent than was Y ( 1 ) -mediated ERK phosphorylation . Positive_regulation EPHB2 PIK3C3 12871951 1142298 dependent *activation* of renal mesangial cell Ki-Ras and [ERK] by advanced glycation end products . Positive_regulation EPHB2 PIK3C3 19479862 2097670 The MAPKs p38 , JNK , and [ERK] were necessary for IL-6 production , but ( PI 3-kinase ) was *required* for selective CCL5 induction . Positive_regulation EPHB2 PIK3C3 23395963 2759344 Bimatoprost induced activation of Akt and [ERK] , and a inhibitor , LY294002 , *attenuated* the protective effect of bimatoprost . Positive_regulation EPHB2 PIK3C3 9366435 463271 Pharmacologic inhibitors were used to examine the roles of tyrosine kinases , phosphatidylinositol 3-kinase , protein kinase C , and phospholipase C. FMLP stimulated [ERK] activity was *dependent* on tyrosine kinases , , protein kinase C , and phospholipase C ; Positive_regulation EPHB2 PIK3CA 11027277 738744 Both inhibitors of and inhibitors of endocytosis prevent GTP loading of Rap1 and *block* sustained [ERK] activation by NGF . Positive_regulation EPHB2 PIK3CA 11027277 738759 PI3-K and endocytosis may also regulate ERK signaling at a second site downstream of Ras , since both rapid [ERK] activation and the Ras dependent activation of the MAP kinase kinase kinase B-Raf are *blocked* by inhibition of either or endocytosis . Positive_regulation EPHB2 PIK3CA 11100733 755933 The G betagamma-responsive [ERK] activation induced by H2O2 is independent of ligands binding to Gi-coupled receptors , but *requires* and Src activation . Positive_regulation EPHB2 PIK3CA 11157888 780938 Inhibition of ( S6K ) activities also unexpectedly *inhibited* [ERK] activity , whereas the converse was not observed , suggesting that PI 3-K acted upstream from ERK and controlled this pathway for CEC proliferation . Positive_regulation EPHB2 PIK3CA 11444915 834157 Analogous to ISO , AII treatment increased [ERK] and PI3-K activity , and was *required* for protein synthesis . Positive_regulation EPHB2 PIK3CA 11453646 837066 The inhibitor LY294002 significantly *inhibited* TNFalpha activation of Rac as well as [Erk] and abolished that of the PI3K target Akt , without showing any inhibitory effects on JNK and p38 activation . Positive_regulation EPHB2 PIK3CA 11535599 868948 PKCzeta and also *contribute* to TPO induced [ERK] activation in MKs , confirming their physiological relevance . Positive_regulation EPHB2 PIK3CA 11673351 872737 IGF-I-stimulation was followed by a *dependent* phosphorylation of AKT and BAD and an MEK1 dependent phosphorylation of extracellular signal regulated kinase ( [ERK] ) 1 and ERK2 . Positive_regulation EPHB2 PIK3CA 11739615 886672 We also found that inhibition of *reduces* BDNF induced [Erk] phosphorylation , indicating that cross-talk between these pathways may play a prominent role in MSNs . Positive_regulation EPHB2 PIK3CA 11818442 908186 p43-Dependent activation of [ERK] was *inhibited* by inhibitors , and the activation of p38 MAPK was not . Positive_regulation EPHB2 PIK3CA 12133817 966982 In addition , PI 3-K is involved in the activation of the Ras-ERK pathway in human HSC , although it is not strictly necessary , since established inhibitors *inhibit* [ERK] activation only by 40-50 % . Positive_regulation EPHB2 PIK3CA 12435806 1015963 In conclusion , CB(1) induced [ERK] activation was *mediated* by ( IB ) and this effect may have important consequences in the control of cell death/survival decision . Positive_regulation EPHB2 PIK3CA 12871951 1142308 Surprisingly , inhibition of *blocks* both [ERK] and Ki-Ras activation . Positive_regulation EPHB2 PIK3CA 15149544 1351024 Surprisingly , three structurally different inhibitors *block* Ras , MEK and [Erk] activation in PEPs by Epo . Positive_regulation EPHB2 PIK3CA 15337530 1291371 We have characterized the *role* of Drosophila and AKT in [ERK] pathway activation involving insulin induced proliferation using Drosophila Schneider cells . Positive_regulation EPHB2 PIK3CA 15344880 1292081 To study the *role* of in insulin stimulation of [ERK] , we employed PI3K inhibitor LY294002 and mouse embryonic R- fibroblasts lacking IGF-1 receptors . Positive_regulation EPHB2 PIK3CA 15361836 1303955 MEK or inhibitors *suppressed* [ERK] or Akt activation , respectively , and induced apoptosis in the v-ErbB : ER-responsive cells . Positive_regulation EPHB2 PIK3CA 15385613 1300129 [ERK] activation by capsaicin and NGF was also *blocked* by inhibitors . Positive_regulation EPHB2 PIK3CA 15917990 1413206 PAF induced [ERK] phosphorylation is *mediated* by , PKC , PLA2 , PLC , and extracellular calcium , whereas fMLP induced ERK phosphorylation does not involve the PKC-gamma isoform and extracellular calcium . Positive_regulation EPHB2 PIK3CA 15937483 1445883 Inhibitors of signaling also *blocked* increases in [ERK/MAP] kinase activity associated with memory retrieval . Positive_regulation EPHB2 PIK3CA 16118117 1449219 The impedance by leptin of the LPS inhibitory effect on mucin synthesis was blocked by wortmannin , an inhibitor of , as well as by [ERK] *inhibitor* , PD98059 . Positive_regulation EPHB2 PIK3CA 16339552 1491635 A *role* for in TCR stimulated [ERK] activation leading to paxillin phosphorylation and CTL degranulation . Positive_regulation EPHB2 PIK3CA 16339552 1491643 We demonstrate that is *required* for TCR stimulated [ERK] activation in CTL , which we have shown previously to be required for CTL degranulation . Positive_regulation EPHB2 PIK3CA 16339552 1491645 These studies demonstrate that *regulates* [ERK] activity leading to CTL degranulation , and identify paxillin as a target of ERK downstream of the TCR . Positive_regulation EPHB2 PIK3CA 16339563 1491666 In that pharmacological inhibitors of *inhibited* LPS induced activation of p21Ras , but not activation of [ERK] , we concluded that LPS induced activation of ERK occurs through a pathway that is not dependent on the activation of p21Ras . Positive_regulation EPHB2 PIK3CA 16754300 1571453 The impedance by PAF antagonist of the LPS induced reduction in mucin synthesis was countered by wortmannin , an inhibitor of , as well as by [ERK] *inhibitor* , PD98059 . Positive_regulation EPHB2 PIK3CA 16983494 1617417 The inhibition by PAF antagonist of the LPS induced reduction in mucin synthesis was countered by wortmannin , an inhibitor of , as well as by [ERK] *inhibitor* , PD98059 . Positive_regulation EPHB2 PIK3CA 17433443 1736803 In cytokine producing Jurkat T cells , we have found that IL-4 induces activation of [Erk] and Akt , and the IL-4 induced STAT6 activity is *suppressed* by inhibitors of Erk and . Positive_regulation EPHB2 PIK3CA 17495535 1744426 In addition , Inhibition of , p38/HOG1 , Raf , and CDK could not *block* the MNNG induced [p-Erk] activation , whereas U0126 and PD98059 abolished it . Positive_regulation EPHB2 PIK3CA 18091994 1838102 We showed that H ( 2 ) O ( 2 ) induces rCMECs apoptosis mainly through the PI3K/ERK pathway , since a inhibitor ( LY294002 ) *blocked* [ERK] activation caused by H ( 2 ) O ( 2 ) and a specific inhibitor of MEK ( U0126 ) protected cells from apoptosis . Positive_regulation EPHB2 PIK3CA 18174382 1889893 Studies with specific chemical inhibitors revealed that the activation of [ERK] was *dependent* on the activation of , whose activation was dependent on Syk , and that sequential activation of these molecules was required for NK cell IFN-gamma production in response to FcR and IL-12 stimulation . Positive_regulation EPHB2 PIK3CA 18275061 1924732 M-CSF activates Ras to coordinate activation of PI3K and [Raf/MEK/ERK] , since Ras inhibition decreased PI3K activation and inhibition did not *block* M-CSF mediated Ras activation . Positive_regulation EPHB2 PIK3CA 18506372 1917986 ERK and inhibitors *inhibit* ECM induced [ERK] , AKT activation and cell proliferation . Positive_regulation EPHB2 PIK3CA 18538131 1928841 OML induced [ERK] phosphorylation was *inhibited* by specific inhibitors of and SFKs , and OML induced Akt phosphorylation was inhibited by a inhibitor of SFKs . Positive_regulation EPHB2 PIK3CA 19047055 2023413 is *required* for both [ERK] and AKT2 activation , whereas AKT2 is sequentially required for GSK-3beta . Positive_regulation EPHB2 PIK3CA 19186178 2054107 Interestingly , activation of signaling *had* differential effects on [ERK] and p38 activation . Positive_regulation EPHB2 PIK3CA 19191907 2127882 The studies with pharmacological inhibitors suggest that calpain inhibition mediated monocyte migration is *mediated* by activation of [ERK] , p38 , JNK , and Rac . Positive_regulation EPHB2 PIK3CA 19225459 2039894 We show that , while PI3K signaling is insulated from cross-talk , *enhances* [Erk] activation at points both upstream and downstream of Ras . Positive_regulation EPHB2 PIK3CA 19299917 2064166 A chemical inhibitor of MEK1/2 or *reduced* phosphorylation of [ERK] or Akt , respectively , and also inhibited CSE mediated MMP-9 induction . Positive_regulation EPHB2 PIK3CA 19351816 2057686 Oncogenic Kras *requires* simultaneous signaling to induce [ERK] activation and transform thyroid epithelial cells in vivo . Positive_regulation EPHB2 PIK3CA 20441566 2274833 In the present study , we evaluated the *role* of specific isoforms alpha , beta , gamma and delta in platelet aggregation , thromboxane A2 generation and [ERK] ( extracellular-signal regulated kinase ) activation . Positive_regulation EPHB2 PIK3CA 20542106 2301959 Activation of these pathways by ATP seemed to be independent , since LY294002 and U0126 , inhibitors of and MEK , did not *block* the activation of [ERK] and AKT , respectively , although each compound blocked its respective target . Positive_regulation EPHB2 PIK3CA 20561929 2290089 The vasoprotective effect of JP05 through the activation of *dependent* eNOS and [MEK/ERK] pathways in brain endothelial cells . Positive_regulation EPHB2 PIK3CA 20732992 2335883 Although the ERK pathway inhibitor U0126 had no effect on Akt activation , the inhibitor LY294002 *reduced* [ERK] activation to near control levels in all SSTR expressing cell lines , suggesting some cross talk between the pathways , possibly at the level of c-Raf , the phosphorylation of which also was induced by SS via each SSTR . Positive_regulation EPHB2 PIK3CA 20809699 2363620 The inhibitor , Ly294002 , *blocked* [ERK] , NF-?B , and PKC ? activation and G-CSF mRNA expression in PBMC induced by PGM . Positive_regulation EPHB2 PIK3CA 20924651 2364680 Insulin- or serum induced stimulation of [ERK] was significantly *suppressed* by depletion of , whereas phosphorylation of IRS-1 and the stimulation of PKB/Akt by insulin were not affected . Positive_regulation EPHB2 PIK3CA 21199670 2391592 In addition , PTTH stimulated ERK phosphorylation of the prothoracic glands was not inhibited by either LY294002 or wortmannin , indicating that is not *involved* in PTTH stimulated [ERK] signaling . Positive_regulation EPHB2 PIK3CA 21412767 2521374 EGF stimulated IL-8 production , phosphorylation of Akt and [Erk] , and cell proliferation and movement could be *inhibited* by EGFR inhibitor ( Erlotinib ) , inhibitor ( GDC-0941 BEZ-235 and SHBM1009 ) , and ERK1/2 inhibitor ( PD98059 ) . Positive_regulation EPHB2 PIK3CA 21490369 2448488 GH-induced [ERK] activation was completely blocked by the ERK pathway inhibitor , U0126 , and the JAK2 inhibitor , 1,2,3,4,5,6-hexabromocyclohexane ( Hex ) , and was partially *blocked* by the inhibitor LY294002 . Positive_regulation EPHB2 PIK3CA 22130357 2535264 In addition , a inhibitor *blocked* the activation of Akt and [ERK] , while Akt knockdown did not affect taurine induced ERK activation , indicating that PI3K is an upstream mediator of both MEK and Akt . Positive_regulation EPHB2 PIK3CA 22543706 2608398 The phosphorylation of [ERK] in the cells was *blocked* by pretreatment with the MEK1 specific inhibitor PD98059 ( 50 µmol/L ) , but not by the inhibitor wortmannin ( 1 µmol/L ) or PKA inhibitor H89 ( 10 µmol/L ) . Positive_regulation EPHB2 PIK3CA 22649371 2522754 Although blockade of the ERK pathway had no effect on the activation of Akt , inhibition of partially *prevented* activation of [ERK] , suggesting cross-talk between the ERK and PI3K-Akt pathways . Positive_regulation EPHB2 PIK3CA 22960230 2684079 Our data suggest that dual inhibitors may represent a useful pharmacological tool in the therapy of advanced adrenocortical cancer and that simultaneous inhibition of both [Erk] and PI3K - mTOR pathways may be *required* to obtain a higher antiproliferative effect in this type of tumor . Positive_regulation EPHB2 PIK3CA 23872471 2835328 The basal [phospho-ERK] level increased gradually throughout a 5-day culture period and was *dependent* as demonstrated by its sensitivity to Wortmannin suggesting it is influenced by growth factors . Positive_regulation EPHB2 PIK3CA 23921150 2854973 Pretreatment of cells with the ERK inhibitor PD98059 , inhibitor LY294002 , and GHSR-siRNA *blocked* the ghrelin induced activation of [ERK] and AKT , respectively ; Positive_regulation EPHB2 PIK3CA 24327733 2880327 *regulates* [MEK/ERK] signaling in breast cancer via the Rac-GEF , P-Rex1 . Positive_regulation EPHB2 PIK3CA 7498528 335886 The results of this study show that in hepatic stellate cells is *involved* in [ERK] activation , although it is not necessary . Positive_regulation EPHB2 PIK3CA 9720763 528541 We report that inhibition of by wortmannin or an inhibitory p85 construct , p85deltaiSH2 , *reduced* the TCR induced Syk dependent activation of Erk2 , as well as the appearance of [phospho-Erk] and phospho-Mek . Positive_regulation EPHB2 PIK3CA 9892010 586559 We show that the activation of [ERK] via SSTR1 is pertussis toxin sensitive and *requires* the small G protein Ras , , the serine/threonine kinase Raf-1 , and the protein tyrosine phosphatase SHP-2 . Positive_regulation EPHB2 PIK3R1 11027277 738745 Both inhibitors of and inhibitors of endocytosis prevent GTP loading of Rap1 and *block* sustained [ERK] activation by NGF . Positive_regulation EPHB2 PIK3R1 11027277 738760 and endocytosis may also *regulate* [ERK] signaling at a second site downstream of Ras , since both rapid ERK activation and the Ras dependent activation of the MAP kinase kinase kinase B-Raf are blocked by inhibition of either PI3-K or endocytosis . Positive_regulation EPHB2 PIK3R1 11100733 755934 The G betagamma-responsive [ERK] activation induced by H2O2 is independent of ligands binding to Gi-coupled receptors , but *requires* and Src activation . Positive_regulation EPHB2 PIK3R1 11157888 780939 Inhibition of ( S6K ) activities also unexpectedly *inhibited* [ERK] activity , whereas the converse was not observed , suggesting that PI 3-K acted upstream from ERK and controlled this pathway for CEC proliferation . Positive_regulation EPHB2 PIK3R1 11444915 834158 Analogous to ISO , AII treatment increased [ERK] and PI3-K activity , and was *required* for protein synthesis . Positive_regulation EPHB2 PIK3R1 11453646 837067 The inhibitor LY294002 significantly *inhibited* TNFalpha activation of Rac as well as [Erk] and abolished that of the PI3K target Akt , without showing any inhibitory effects on JNK and p38 activation . Positive_regulation EPHB2 PIK3R1 11535599 868949 PKCzeta and also *contribute* to TPO induced [ERK] activation in MKs , confirming their physiological relevance . Positive_regulation EPHB2 PIK3R1 11673351 872738 IGF-I-stimulation was followed by a *dependent* phosphorylation of AKT and BAD and an MEK1 dependent phosphorylation of extracellular signal regulated kinase ( [ERK] ) 1 and ERK2 . Positive_regulation EPHB2 PIK3R1 11739615 886673 We also found that inhibition of *reduces* BDNF induced [Erk] phosphorylation , indicating that cross-talk between these pathways may play a prominent role in MSNs . Positive_regulation EPHB2 PIK3R1 11818442 908187 p43-Dependent activation of [ERK] was *inhibited* by inhibitors , and the activation of p38 MAPK was not . Positive_regulation EPHB2 PIK3R1 12133817 966983 In addition , PI 3-K is involved in the activation of the Ras-ERK pathway in human HSC , although it is not strictly necessary , since established inhibitors *inhibit* [ERK] activation only by 40-50 % . Positive_regulation EPHB2 PIK3R1 12435806 1015964 In conclusion , CB(1) induced [ERK] activation was *mediated* by ( IB ) and this effect may have important consequences in the control of cell death/survival decision . Positive_regulation EPHB2 PIK3R1 12871951 1142309 Surprisingly , inhibition of *blocks* both [ERK] and Ki-Ras activation . Positive_regulation EPHB2 PIK3R1 15149544 1351025 Surprisingly , three structurally different inhibitors *block* Ras , MEK and [Erk] activation in PEPs by Epo . Positive_regulation EPHB2 PIK3R1 15337530 1291372 We have characterized the *role* of Drosophila and AKT in [ERK] pathway activation involving insulin induced proliferation using Drosophila Schneider cells . Positive_regulation EPHB2 PIK3R1 15344880 1292082 To study the *role* of in insulin stimulation of [ERK] , we employed PI3K inhibitor LY294002 and mouse embryonic R- fibroblasts lacking IGF-1 receptors . Positive_regulation EPHB2 PIK3R1 15361836 1303956 MEK or inhibitors *suppressed* [ERK] or Akt activation , respectively , and induced apoptosis in the v-ErbB : ER-responsive cells . Positive_regulation EPHB2 PIK3R1 15385613 1300130 [ERK] activation by capsaicin and NGF was also *blocked* by inhibitors . Positive_regulation EPHB2 PIK3R1 15917990 1413207 PAF induced [ERK] phosphorylation is *mediated* by , PKC , PLA2 , PLC , and extracellular calcium , whereas fMLP induced ERK phosphorylation does not involve the PKC-gamma isoform and extracellular calcium . Positive_regulation EPHB2 PIK3R1 15937483 1445884 Inhibitors of signaling also *blocked* increases in [ERK/MAP] kinase activity associated with memory retrieval . Positive_regulation EPHB2 PIK3R1 16118117 1449220 The impedance by leptin of the LPS inhibitory effect on mucin synthesis was blocked by wortmannin , an inhibitor of , as well as by [ERK] *inhibitor* , PD98059 . Positive_regulation EPHB2 PIK3R1 16339552 1491636 A *role* for in TCR stimulated [ERK] activation leading to paxillin phosphorylation and CTL degranulation . Positive_regulation EPHB2 PIK3R1 16339552 1491644 We demonstrate that is *required* for TCR stimulated [ERK] activation in CTL , which we have shown previously to be required for CTL degranulation . Positive_regulation EPHB2 PIK3R1 16339552 1491646 These studies demonstrate that *regulates* [ERK] activity leading to CTL degranulation , and identify paxillin as a target of ERK downstream of the TCR . Positive_regulation EPHB2 PIK3R1 16339563 1491667 In that pharmacological inhibitors of *inhibited* LPS induced activation of p21Ras , but not activation of [ERK] , we concluded that LPS induced activation of ERK occurs through a pathway that is not dependent on the activation of p21Ras . Positive_regulation EPHB2 PIK3R1 16754300 1571454 The impedance by PAF antagonist of the LPS induced reduction in mucin synthesis was countered by wortmannin , an inhibitor of , as well as by [ERK] *inhibitor* , PD98059 . Positive_regulation EPHB2 PIK3R1 16983494 1617418 The inhibition by PAF antagonist of the LPS induced reduction in mucin synthesis was countered by wortmannin , an inhibitor of , as well as by [ERK] *inhibitor* , PD98059 . Positive_regulation EPHB2 PIK3R1 17433443 1736804 In cytokine producing Jurkat T cells , we have found that IL-4 induces activation of [Erk] and Akt , and the IL-4 induced STAT6 activity is *suppressed* by inhibitors of Erk and . Positive_regulation EPHB2 PIK3R1 17495535 1744427 In addition , Inhibition of , p38/HOG1 , Raf , and CDK could not *block* the MNNG induced [p-Erk] activation , whereas U0126 and PD98059 abolished it . Positive_regulation EPHB2 PIK3R1 18091994 1838103 We showed that H ( 2 ) O ( 2 ) induces rCMECs apoptosis mainly through the PI3K/ERK pathway , since a inhibitor ( LY294002 ) *blocked* [ERK] activation caused by H ( 2 ) O ( 2 ) and a specific inhibitor of MEK ( U0126 ) protected cells from apoptosis . Positive_regulation EPHB2 PIK3R1 18174382 1889894 Studies with specific chemical inhibitors revealed that the activation of [ERK] was *dependent* on the activation of , whose activation was dependent on Syk , and that sequential activation of these molecules was required for NK cell IFN-gamma production in response to FcR and IL-12 stimulation . Positive_regulation EPHB2 PIK3R1 18275061 1924733 M-CSF activates Ras to coordinate activation of PI3K and [Raf/MEK/ERK] , since Ras inhibition decreased PI3K activation and inhibition did not *block* M-CSF mediated Ras activation . Positive_regulation EPHB2 PIK3R1 18506372 1917987 ERK and inhibitors *inhibit* ECM induced [ERK] , AKT activation and cell proliferation . Positive_regulation EPHB2 PIK3R1 18538131 1928842 OML induced [ERK] phosphorylation was *inhibited* by specific inhibitors of and SFKs , and OML induced Akt phosphorylation was inhibited by a inhibitor of SFKs . Positive_regulation EPHB2 PIK3R1 19047055 2023414 is *required* for both [ERK] and AKT2 activation , whereas AKT2 is sequentially required for GSK-3beta . Positive_regulation EPHB2 PIK3R1 19186178 2054108 Interestingly , activation of signaling *had* differential effects on [ERK] and p38 activation . Positive_regulation EPHB2 PIK3R1 19191907 2127883 The studies with pharmacological inhibitors suggest that calpain inhibition mediated monocyte migration is *mediated* by activation of [ERK] , p38 , JNK , and Rac . Positive_regulation EPHB2 PIK3R1 19225459 2039895 We show that , while PI3K signaling is insulated from cross-talk , *enhances* [Erk] activation at points both upstream and downstream of Ras . Positive_regulation EPHB2 PIK3R1 19299917 2064167 A chemical inhibitor of MEK1/2 or *reduced* phosphorylation of [ERK] or Akt , respectively , and also inhibited CSE mediated MMP-9 induction . Positive_regulation EPHB2 PIK3R1 19351816 2057687 Oncogenic Kras *requires* simultaneous signaling to induce [ERK] activation and transform thyroid epithelial cells in vivo . Positive_regulation EPHB2 PIK3R1 20441566 2274834 In the present study , we evaluated the *role* of specific isoforms alpha , beta , gamma and delta in platelet aggregation , thromboxane A2 generation and [ERK] ( extracellular-signal regulated kinase ) activation . Positive_regulation EPHB2 PIK3R1 20542106 2301960 Activation of these pathways by ATP seemed to be independent , since LY294002 and U0126 , inhibitors of and MEK , did not *block* the activation of [ERK] and AKT , respectively , although each compound blocked its respective target . Positive_regulation EPHB2 PIK3R1 20561929 2290090 The vasoprotective effect of JP05 through the activation of *dependent* eNOS and [MEK/ERK] pathways in brain endothelial cells . Positive_regulation EPHB2 PIK3R1 20732992 2335884 Although the ERK pathway inhibitor U0126 had no effect on Akt activation , the inhibitor LY294002 *reduced* [ERK] activation to near control levels in all SSTR expressing cell lines , suggesting some cross talk between the pathways , possibly at the level of c-Raf , the phosphorylation of which also was induced by SS via each SSTR . Positive_regulation EPHB2 PIK3R1 20809699 2363621 The inhibitor , Ly294002 , *blocked* [ERK] , NF-?B , and PKC ? activation and G-CSF mRNA expression in PBMC induced by PGM . Positive_regulation EPHB2 PIK3R1 20924651 2364681 Insulin- or serum induced stimulation of [ERK] was significantly *suppressed* by depletion of , whereas phosphorylation of IRS-1 and the stimulation of PKB/Akt by insulin were not affected . Positive_regulation EPHB2 PIK3R1 21199670 2391593 In addition , PTTH stimulated ERK phosphorylation of the prothoracic glands was not inhibited by either LY294002 or wortmannin , indicating that is not *involved* in PTTH stimulated [ERK] signaling . Positive_regulation EPHB2 PIK3R1 21412767 2521375 EGF stimulated IL-8 production , phosphorylation of Akt and [Erk] , and cell proliferation and movement could be *inhibited* by EGFR inhibitor ( Erlotinib ) , inhibitor ( GDC-0941 BEZ-235 and SHBM1009 ) , and ERK1/2 inhibitor ( PD98059 ) . Positive_regulation EPHB2 PIK3R1 21490369 2448489 GH-induced [ERK] activation was completely blocked by the ERK pathway inhibitor , U0126 , and the JAK2 inhibitor , 1,2,3,4,5,6-hexabromocyclohexane ( Hex ) , and was partially *blocked* by the inhibitor LY294002 . Positive_regulation EPHB2 PIK3R1 22130357 2535265 In addition , a inhibitor *blocked* the activation of Akt and [ERK] , while Akt knockdown did not affect taurine induced ERK activation , indicating that PI3K is an upstream mediator of both MEK and Akt . Positive_regulation EPHB2 PIK3R1 22543706 2608399 The phosphorylation of [ERK] in the cells was *blocked* by pretreatment with the MEK1 specific inhibitor PD98059 ( 50 µmol/L ) , but not by the inhibitor wortmannin ( 1 µmol/L ) or PKA inhibitor H89 ( 10 µmol/L ) . Positive_regulation EPHB2 PIK3R1 22649371 2522755 Although blockade of the ERK pathway had no effect on the activation of Akt , inhibition of partially *prevented* activation of [ERK] , suggesting cross-talk between the ERK and PI3K-Akt pathways . Positive_regulation EPHB2 PIK3R1 22960230 2684080 Our data suggest that dual inhibitors may represent a useful pharmacological tool in the therapy of advanced adrenocortical cancer and that simultaneous inhibition of both [Erk] and PI3K - mTOR pathways may be *required* to obtain a higher antiproliferative effect in this type of tumor . Positive_regulation EPHB2 PIK3R1 23872471 2835329 The basal [phospho-ERK] level increased gradually throughout a 5-day culture period and was *dependent* as demonstrated by its sensitivity to Wortmannin suggesting it is influenced by growth factors . Positive_regulation EPHB2 PIK3R1 23921150 2854974 Pretreatment of cells with the ERK inhibitor PD98059 , inhibitor LY294002 , and GHSR-siRNA *blocked* the ghrelin induced activation of [ERK] and AKT , respectively ; Positive_regulation EPHB2 PIK3R1 24327733 2880328 *regulates* [MEK/ERK] signaling in breast cancer via the Rac-GEF , P-Rex1 . Positive_regulation EPHB2 PIK3R1 7498528 335887 The results of this study show that in hepatic stellate cells is *involved* in [ERK] activation , although it is not necessary . Positive_regulation EPHB2 PIK3R1 9720763 528542 We report that inhibition of by wortmannin or an inhibitory p85 construct , p85deltaiSH2 , *reduced* the TCR induced Syk dependent activation of Erk2 , as well as the appearance of [phospho-Erk] and phospho-Mek . Positive_regulation EPHB2 PIK3R1 9892010 586560 We show that the activation of [ERK] via SSTR1 is pertussis toxin sensitive and *requires* the small G protein Ras , , the serine/threonine kinase Raf-1 , and the protein tyrosine phosphatase SHP-2 . Positive_regulation EPHB2 PIK3R4 11853873 913395 Additionally , Y(5) receptor mediated [ERK] phosphorylation was *inhibited* by the inhibitors LY294002 and wortmannin to a greater extent than was Y ( 1 ) -mediated ERK phosphorylation . Positive_regulation EPHB2 PIK3R4 12871951 1142299 *dependent* activation of renal mesangial cell Ki-Ras and [ERK] by advanced glycation end products . Positive_regulation EPHB2 PIK3R4 19479862 2097671 The MAPKs p38 , JNK , and [ERK] were necessary for IL-6 production , but ( PI 3-kinase ) was *required* for selective CCL5 induction . Positive_regulation EPHB2 PIK3R4 23395963 2759345 Bimatoprost induced activation of Akt and [ERK] , and a inhibitor , LY294002 , *attenuated* the protective effect of bimatoprost . Positive_regulation EPHB2 PIK3R4 9366435 463272 Pharmacologic inhibitors were used to examine the roles of tyrosine kinases , phosphatidylinositol 3-kinase , protein kinase C , and phospholipase C. FMLP stimulated [ERK] activity was *dependent* on tyrosine kinases , , protein kinase C , and phospholipase C ; Positive_regulation EPHB2 PKD2 19098310 2042017 In addition , we found that [ERK] activation was *induced* by overexpression via B-Raf signaling , providing a possible molecular mechanism of cystogenesis . Positive_regulation EPHB2 PKD2 19520973 2120878 Using multiple approaches , including dominant negative mutants and small interfering RNA knock-down , we found that lysoPC induced activation was *required* for the activation of both [ERK] and p38 MAPK . Positive_regulation EPHB2 PKN1 10880347 762388 Transfection of dominant negative PAK1 blocked 12-HETE induced PAK1 , cJun N-terminal kinase ( JNK1 ) and extracellular-signal regulated kinase ( ERK ) activity , while transfection of constitutively active PAK1 stimulated PAK1 , JNK1 and ERK activity , suggesting that is an upstream *activator* of 12-HETE induced JNK1 and [ERK] activation in these cells . Positive_regulation EPHB2 PKN1 15597056 1346489 Also , we found that kinase activity *contributes* to [ERK] activation by L1 , and is necessary for L1-potentiated haptotactic cell migration . Positive_regulation EPHB2 PKN1 15923628 1414012 Here we show that the putative scaffold protein MEK partner 1 (MP1) and its partner p14 regulate dependent ERK activation during adhesion and cell spreading but are not *required* for [ERK] activation by platelet derived growth factor . Positive_regulation EPHB2 PKN1 20526801 2320146 However , specific depletion of Pak1 by siRNA has no effect on PDGF induced ERK phosphorylation , indicating that in MB cells [ERK] signaling is Pak1 independent , but PDGF induced migration is *dependent* on ERK mediated activation of . Positive_regulation EPHB2 PKN1 21037231 2370222 Overexpression of PKN1 significantly increased ERK phosphorylation , whereas downregulation of *inhibited* HS-induced [ERK] phosphorylation . Positive_regulation EPHB2 PKN1 25074784 2953909 Furthermore , EOPK suppressed PAK1 expression in a dose dependent manner , and this suppression of *led* to inhibition of [ERK] , AKT , and ß-catenin activities . Positive_regulation EPHB2 PLA2G1B 18550646 1940628 Pharmacological inhibition of did not *prevent* PTH stimulated [ERK] phosphorylation but completely prevented PKCalpha translocation . Positive_regulation EPHB2 PLA2G4A 10897414 711857 Activation of by opsonized zymosan in human neutrophils *requires* both [ERK] and p38 MAP-kinase . Positive_regulation EPHB2 PLA2G4A 12379481 997272 We conclude that the calcium ionophore A23187 and the receptor agonist fMLP both act through common pathways to stimulate PAF synthesis , with p38 MAP kinase regulating acetyltransferase and supplementing [ERK] *activation* of . Positive_regulation EPHB2 PLA2G4A 15894894 1407887 These results suggest that either [ERK] or p38 MAP-kinase are involved in the activation of both cPLA2 and NADPH oxidase , and that is *required* for activation of the NADPH oxidase by Ang II in human neutrophils . Positive_regulation EPHB2 PLA2G4A 21294165 2388300 ( 3 ) we indicated that ATP stimulates the definitely release of AA and PGE2 which involved the transactivation of epidermal growth factor (EGF) receptor , the phosphorylation of extracellular regulated protein kinases 1 and 2 ( [ERK] ( 1/2 ) ) and the *activation* of ( cPLA(2) ) ; Positive_regulation EPHB2 PLAT 11266465 796865 [ERK] phosphorylation was not *induced* by complex or by uPA-PAI-1 complex in the presence of antibodies that block uPA binding to uPAR . Positive_regulation EPHB2 PLAT 15625301 1362082 Western blots of ischemic brain lysates showed that markedly diminished eNOS levels , *increased* [extracellular regulated kinase (ERK)-2] , and decreased MAP kinase/p38 activity . Positive_regulation EPHB2 PLAT 17498240 1739842 Consistent with neurotrophic effects , *activated* [Raf-K/ERK] , PKC and PI3-K/Akt , 5-60 min after treatment . Positive_regulation EPHB2 PLAT 22162045 2549119 We found that *induces* a catalytic independent rapid and sustained activation of extracellular signal regulated kinase ( [ERK] ) 1/2 , Jun N-terminal kinase (JNK) , Akt , and p38 signaling pathways . Positive_regulation EPHB2 PLAT 22743997 2696969 Thus , *enhances* NMDAR mediated calcium influx , [Erk] ( ½ ) activation and neurotoxicity in cultured cortical neurons , excitotoxicity in the striatum and NMDAR dependent long-term potentiation in the hippocampal CA-1 network . Positive_regulation EPHB2 PLAT 23731391 2853953 Our recent work shows that a catalytically inactive tPA variant ( tPA-S ( 481 ) A ) that competes with endogenous wild type ( wt ) tPA for binding to NMDA-R through its receptor docking site but that can not activate it , prevents *activation* of [ERK] by wt and impairment of autoregulation when administered 30 min after fluid percussion injury ( FPI ) . Positive_regulation EPHB2 PLAU 10402467 628946 Ras and MAP kinase kinase (MEK) were necessary and sufficient for *induced* [ERK] activation and stimulation of cellular migration , as demonstrated in experiments with dominant negative and constitutively active mutants of these signaling proteins . Positive_regulation EPHB2 PLAU 11266465 796866 [ERK] phosphorylation was not *induced* by tissue-type plasminogen activator-PAI-1 complex or by complex in the presence of antibodies that block uPA binding to uPAR . Positive_regulation EPHB2 PLAU 12124174 965669 receptor ( uPAR ) *activates* alpha5beta1 integrin and [ERK] signaling , inducing in vivo proliferation of HEp3 human carcinoma . Positive_regulation EPHB2 PLAU 12426305 1036643 however , these cells demonstrated [ERK] activation in *response* to , indicating the presence of an EGFR independent alternative pathway . Positive_regulation EPHB2 PLAU 12426305 1036645 When CHO-K1 cells were transfected to express EGFR or a kinase-inactive mutant of EGFR , [ERK] activation in *response* to was unchanged ; Positive_regulation EPHB2 PLAU 12865932 1111963 Downregulation of receptor expression *inhibits* [Erk] signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells . Positive_regulation EPHB2 PLAU 12865932 1111965 In contrast , in A/S cells , *induction* of [Erk] activation was not observed . Positive_regulation EPHB2 PLAU 15284295 1277982 Enhanced proliferation of uPAR-/- fibroblasts seems to be mediated by *dependent* [ERK] signaling via an alternative urokinase receptor . Positive_regulation EPHB2 PLAU 15573379 1402214 Stimulation with human specifically *induced* phosphorylation of [early response regulated kinase (ERK)] in cells expressing human uPAR but not in sham transfected cells . Positive_regulation EPHB2 PLAU 15728176 1396242 In this study , we demonstrate that [ERK] activation in *response* to follows equivalent biphasic kinetics in EGFR expressing and -deficient CHO-K1 cells . Positive_regulation EPHB2 PLAU 17681345 1822243 Finally , uPA was found to activate MAP-kinase through PI3 kinase (PI3K) , as PI3K inhibition abrogated both *induced* [ERK] phosphorylation and cholesterol biosynthesis . Positive_regulation EPHB2 PLAU 17963689 1850029 We have also tested *induced* [ERK] phosphorylation in the presence of methyl-beta-cyclodextrin , which is known to disrupt lipid rafts by sequestering cholesterol from such domains . Positive_regulation EPHB2 PLAU 18495808 1933711 *dependent* [ERK] activation and uPAR internalization regulate cell survival and migration . Positive_regulation EPHB2 PLAU 18495808 1933712 In a 2-D system , we found that exogenous *induced* [ERK] phosphorylation and uPAR internalization were blocked by HKa . Positive_regulation EPHB2 PLAU 18656457 1960559 Exogenous administered at 4 h post H/I further *stimulated* [ERK] MAPK phosphorylation , which was blocked by RAP . Positive_regulation EPHB2 PLAU 21426933 2427295 Downregulation of and uPAR , simultaneously by transfecting the cancer cells with bi-cistronic siRNA expressing plasmid ( pU ) *inhibited* radiation induced [ERK] activation , nuclear translocation of Rel-A , NF-?B DNA binding activity , and MCP-1 expression . Positive_regulation EPHB2 PLAUR 11266465 796886 The kinetics of [ERK] phosphorylation in *response* to ligation determine the function of uPA and uPA-PAI-1 complex as growth promoters . Positive_regulation EPHB2 PLAUR 12865932 1111964 Antisense inhibition of the cell surface expression of by 50 % in human colon carcinoma HCT116 cells ( A/S ) *suppressed* [Erk-MAP] kinase activity by two-fold . Positive_regulation EPHB2 PLAUR 15389548 1304766 Like NFLC , induction of , transin/matrix metalloproteinase 3 (MMP3) , Fra-1 and transforming growth factor beta 1 ( TGF beta 1 ) *required* collaborative [ERK] and JNK signaling while the increased expression of cortexin , rat collapsin response mediator protein 4 ( rCRMP4 ) , rat growth and transformation dependent protein ( RGT ) , and synapsin II required neither mitogen activated protein kinase (MAPK) pathway . Positive_regulation EPHB2 PLAUR 16267271 1502279 On the contrary , does not *activate* [ERK] and does not engage FPRL1 or any other G protein coupled receptor , but it activates an alternative pathway initiated by the formation of a triple complex ( uPAR-alpha3beta1-EGFR ) and resulting in the autotyrosine phosphorylation of EGFR . Positive_regulation EPHB2 PLAUR 19242538 2040578 Disruption of interaction *blocks* [ERK] activation and forces cancer cells into dormancy . Positive_regulation EPHB2 PLAUR 19242538 2040579 Of these 68 chemical hits , ten inhibited ERK activation in a cellular assay and of those , 2 compounds , 2- ( Pyridin-2-ylamino ) -quinolin-8-ol and , 2,2'- ( methylimino ) di ( 8-quinolinol ) *inhibited* [ERK] activation by disrupting the interaction . Positive_regulation EPHB2 PLAUR 21426933 2427296 Downregulation of uPA and , simultaneously by transfecting the cancer cells with bi-cistronic siRNA expressing plasmid ( pU ) *inhibited* radiation induced [ERK] activation , nuclear translocation of Rel-A , NF-?B DNA binding activity , and MCP-1 expression . Positive_regulation EPHB2 PLAUR 21803847 2484750 We also demonstrated that VEGF dependent [ERK] phosphorylation *required* integrity of caveolae as well as caveolar expression . Positive_regulation EPHB2 PLAUR 21896743 2487034 Here , we show that does not *regulate* [ERK] activation in EGFRvIII expressing GBM cells ; Positive_regulation EPHB2 PLAUR 22617030 2614667 Autonomous [ERK] *activation* by requires H-Ras and Rac1 . Positive_regulation EPHB2 PLCG1 10958690 726175 The PTEN-deficient cells were also hyperresponsive to T-cell receptor ( TCR ) stimulation , as measured by Itk kinase activity , tyrosine phosphorylation of , and *activation* of [Erk] compared to those in PTEN-replete cells . Positive_regulation EPHB2 PLCG1 17119112 1700617 Although RhoH is not required for TCR induced activation of ZAP70 and ZAP70 mediated activation of p38 , it is crucial for the tyrosine phosphorylation of LAT , , and Vav1 and for the *activation* of [Erk] and calcium influx . Positive_regulation EPHB2 PLCG1 17524370 1762100 HSV mediated overexpression of PLCgamma1 in PC12 cells induced ERK activation via a mechanism dependent , in part , on both MAP-ERK kinase (MEK) and protein kinase C . overexpression in the VTA similarly *induced* [ERK] activation in the VTA in vivo . Positive_regulation EPHB2 PLCG1 20123962 2207013 We demonstrate that deficiency affects positive and negative selection , significantly reduces single positive thymocytes and peripheral T cells , and *impairs* TCR induced proliferation and cytokine production , and the activation of [ERK] , JNK , AP-1 , NFAT , and NF-kappaB . Positive_regulation EPHB2 PLCG2 15728130 1409636 This response was characterized by transient phosphorylation of extracellular signal related kinase ( [ERK] ) and Akt ( protein kinase B [ PKB ] ) , lack of activation of c-JUN NH2-terminal kinase (JNK) and p38 mitogen activated protein kinase (MAPK) , and variable *activation* of ( PLCgamma2 ) and nuclear factor-kappaB (NF-kappaB) . Positive_regulation EPHB2 PLCG2 21074890 2407167 CD40 stimulation alone also activates B cell linker (BLNK) , Bruton tyrosine kinase (Btk) , and Vav-2 downstream of Syk , and significantly enhances BCR induced formation of complex consisting of , Vav-2 , Btk , BLNK , and ( PLC-?2 ) *leading* to activation of extracellular signal regulated kinase ( [ERK] ) , p38 mitogen activated protein kinase , Akt , and NF-?B required for optimal B cell activation . Positive_regulation EPHB2 PLD1 11243883 792269 *Enhancement* of lysophosphatidic acid induced [ERK] phosphorylation by via the formation of phosphatidic acid . Positive_regulation EPHB2 PLD1 12149127 997554 The *roles* of and PLD2 in [ERK] activation and IL-8 secretion activated by S1P were investigated by infecting cells with adenoviral constructs of wild-type and catalytically inactive mutants of PLD1 and PLD2 . Positive_regulation EPHB2 PLD1 12782152 1095844 ERK activation by PMA was unaffected by n-butanol in Cl8 cells but almost abolished by n-butanol in Cl8 HAbetaC2-1 cells , showing that [ERK] activation by PMA is heavily *dependent* on PKC and . Positive_regulation EPHB2 PLD1 12890486 1117275 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Positive_regulation EPHB2 PLD1 12890486 1117400 Ang1 induced MEK/ERK activation was abrogated when PLD was inhibited , suggesting that *mediates* Ang1 induced [MEK/ERK] activation . Positive_regulation EPHB2 PLD1 14704231 1225461 A inhibitor , 1-butanol , almost completely *suppressed* VEGF induced [ERK] phosphorylation and cellular proliferation , whereas the negative control for 1-butanol , 3-butanol , did not produce significant changes . Positive_regulation EPHB2 PLD1 15325847 1287284 Taken together , we found that WKYMVm stimulated FPRL1 , and that this resulted in STAT3 serine phosphorylation via mediated [ERK] *activation* , and that the serine phosphorylation of STAT3 blocked hydrogen peroxide induced STAT3 activity . Positive_regulation EPHB2 PLD1 15355882 1353870 Collectively , these data indicate that ET-1 is a potent mitogenic factor in ELT-3 cells via a signaling pathway involving a *dependent* activation of [ERK] . Positive_regulation EPHB2 PLD1 20231899 2223819 Finally , the extracellular stresses caused by glucose deprivation or aminoimidazole carboxamide ribonucleotide ( AICAR ; AMPK activator ) regulate ( 14 ) C-glucose uptake and cell surface glucose transport (GLUT) 4 through [ERK] *stimulation* by AMPK mediated activation . Positive_regulation EPHB2 PLD1 24164897 2889685 While inhibition of both PLD and DGK had no effect on the overall ERK activity , inhibition of PLD2 but not or DGK *blocked* the nuclear [ERK] activity in several cancer cell lines . Positive_regulation EPHB2 PLD2 12149127 997555 The *roles* of PLD1 and in [ERK] activation and IL-8 secretion activated by S1P were investigated by infecting cells with adenoviral constructs of wild-type and catalytically inactive mutants of PLD1 and PLD2 . Positive_regulation EPHB2 PLD2 12890486 1117276 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Positive_regulation EPHB2 PLD2 12890486 1117401 Ang1 induced MEK/ERK activation was abrogated when PLD was inhibited , suggesting that *mediates* Ang1 induced [MEK/ERK] activation . Positive_regulation EPHB2 PLD2 14704231 1225412 Localization of VEGFR-2 and in endothelial caveolae is *involved* in VEGF induced phosphorylation of MEK and [ERK] . Positive_regulation EPHB2 PLD2 14704231 1225462 A inhibitor , 1-butanol , almost completely *suppressed* VEGF induced [ERK] phosphorylation and cellular proliferation , whereas the negative control for 1-butanol , 3-butanol , did not produce significant changes . Positive_regulation EPHB2 PLD2 15325847 1287285 Taken together , we found that WKYMVm stimulated FPRL1 , and that this resulted in STAT3 serine phosphorylation via mediated [ERK] *activation* , and that the serine phosphorylation of STAT3 blocked hydrogen peroxide induced STAT3 activity . Positive_regulation EPHB2 PLD2 15355882 1353871 Collectively , these data indicate that ET-1 is a potent mitogenic factor in ELT-3 cells via a signaling pathway involving a dependent *activation* of [ERK] . Positive_regulation EPHB2 PLD2 24164897 2889686 While inhibition of both PLD and DGK had no effect on the overall ERK activity , inhibition of but not PLD1 or DGK *blocked* the nuclear [ERK] activity in several cancer cell lines . Positive_regulation EPHB2 PLD3 12890486 1117270 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Positive_regulation EPHB2 PLD3 12890486 1117395 Ang1 induced MEK/ERK activation was abrogated when PLD was inhibited , suggesting that *mediates* Ang1 induced [MEK/ERK] activation . Positive_regulation EPHB2 PLD3 14704231 1225457 A inhibitor , 1-butanol , almost completely *suppressed* VEGF induced [ERK] phosphorylation and cellular proliferation , whereas the negative control for 1-butanol , 3-butanol , did not produce significant changes . Positive_regulation EPHB2 PLD3 15325847 1287280 Taken together , we found that WKYMVm stimulated FPRL1 , and that this resulted in STAT3 serine phosphorylation via mediated [ERK] *activation* , and that the serine phosphorylation of STAT3 blocked hydrogen peroxide induced STAT3 activity . Positive_regulation EPHB2 PLD3 15355882 1353866 Collectively , these data indicate that ET-1 is a potent mitogenic factor in ELT-3 cells via a signaling pathway involving a *dependent* activation of [ERK] . Positive_regulation EPHB2 PLD4 12890486 1117271 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Positive_regulation EPHB2 PLD4 12890486 1117396 Ang1 induced MEK/ERK activation was abrogated when PLD was inhibited , suggesting that *mediates* Ang1 induced [MEK/ERK] activation . Positive_regulation EPHB2 PLD4 14704231 1225458 A inhibitor , 1-butanol , almost completely *suppressed* VEGF induced [ERK] phosphorylation and cellular proliferation , whereas the negative control for 1-butanol , 3-butanol , did not produce significant changes . Positive_regulation EPHB2 PLD4 15325847 1287281 Taken together , we found that WKYMVm stimulated FPRL1 , and that this resulted in STAT3 serine phosphorylation via mediated [ERK] *activation* , and that the serine phosphorylation of STAT3 blocked hydrogen peroxide induced STAT3 activity . Positive_regulation EPHB2 PLD4 15355882 1353867 Collectively , these data indicate that ET-1 is a potent mitogenic factor in ELT-3 cells via a signaling pathway involving a dependent *activation* of [ERK] . Positive_regulation EPHB2 PLD5 12890486 1117272 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Positive_regulation EPHB2 PLD5 12890486 1117397 Ang1 induced MEK/ERK activation was abrogated when PLD was inhibited , suggesting that *mediates* Ang1 induced [MEK/ERK] activation . Positive_regulation EPHB2 PLD5 14704231 1225459 A inhibitor , 1-butanol , almost completely *suppressed* VEGF induced [ERK] phosphorylation and cellular proliferation , whereas the negative control for 1-butanol , 3-butanol , did not produce significant changes . Positive_regulation EPHB2 PLD5 15325847 1287282 Taken together , we found that WKYMVm stimulated FPRL1 , and that this resulted in STAT3 serine phosphorylation via mediated [ERK] *activation* , and that the serine phosphorylation of STAT3 blocked hydrogen peroxide induced STAT3 activity . Positive_regulation EPHB2 PLD5 15355882 1353868 Collectively , these data indicate that ET-1 is a potent mitogenic factor in ELT-3 cells via a signaling pathway involving a *dependent* activation of [ERK] . Positive_regulation EPHB2 PLD6 12890486 1117273 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Positive_regulation EPHB2 PLD6 12890486 1117398 Ang1 induced MEK/ERK activation was abrogated when PLD was inhibited , suggesting that *mediates* Ang1 induced [MEK/ERK] activation . Positive_regulation EPHB2 PLD6 14704231 1225460 A inhibitor , 1-butanol , almost completely *suppressed* VEGF induced [ERK] phosphorylation and cellular proliferation , whereas the negative control for 1-butanol , 3-butanol , did not produce significant changes . Positive_regulation EPHB2 PLD6 15325847 1287283 Taken together , we found that WKYMVm stimulated FPRL1 , and that this resulted in STAT3 serine phosphorylation via mediated [ERK] *activation* , and that the serine phosphorylation of STAT3 blocked hydrogen peroxide induced STAT3 activity . Positive_regulation EPHB2 PLD6 15355882 1353869 Collectively , these data indicate that ET-1 is a potent mitogenic factor in ELT-3 cells via a signaling pathway involving a dependent *activation* of [ERK] . Positive_regulation EPHB2 PLG 16225843 1469492 Here we show that *activates* the mitogen activated protein kinases MEK and [ERK] which leads to alpha-enolase (alpha-ENO) gene expression not only in fibroblasts , but also in peripheral blood mononuclear cells . Positive_regulation EPHB2 PLG 17267741 1704187 Both *induced* [ERK] activation and EMT were significantly blocked in vitro by the protease activated receptor-1 (PAR-1) silencing RNA ; Positive_regulation EPHB2 PLP1 23000254 2716266 We showed that *increased* [ERK] , JNK , and p38 mitogen activated protein kinase phosphorylation , and nuclear translocation of the nuclear factor-kappaB p65 subunit , which are signaling molecules downstream of TLR4 . Positive_regulation EPHB2 PLTP 24532668 2933517 Silencing at baseline *caused* a 68 % increase in inflammatory cell infiltration , a 120 and 340 % increase in [ERK] and NF-?B activation , and increased MMP-9 , IL1ß , and IFN-? levels after LPS treatment by 39 , 140 , and 190 % , respectively . Positive_regulation EPHB2 POLDIP2 10501195 648307 Inhibition of p38 MAPK had no significant effect on opioid induced ERK activation , indicating that MAPK activity was not *required* for [ERK] activation , though its stimulation preceded ERK activation . Positive_regulation EPHB2 POLDIP2 10872747 707007 Pre-treatment of the cells with PD98059 , a selective [ERK] pathway *inhibitor* , and SB203580 , a MAPK inhibitor , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation EPHB2 POLDIP2 11446731 835417 These results indicate that activation of extracellular-signal regulated kinase ( [ERK] ) is required for TPO induced megakaryocyte differentiation and that is *required* for TPO induced erythroid differentiation . Positive_regulation EPHB2 POLDIP2 15358225 1293398 A specific inhibitor of JNK , SP600125 , abolished paclitaxel induced HO-1 mRNA expression , whereas PD98059 , a specific *inhibitor* of [ERK] , and SB203580 , a specific inhibitor of , had no significant effect . Positive_regulation EPHB2 POLDIP2 15480794 1342487 These alterations in protein level of adhesion molecules and in the phosphorylation of mitogen activated protein kinases by glucose were blocked by inhibition of PKC or but were synergistically *increased* by the inhibition of [ERK] . Positive_regulation EPHB2 POLDIP2 15964118 1428217 In addition , the malvidin treatment significantly increased the p38 kinase expression and *inhibited* the [ERK] activity , and the effects of malvidin on caspase-3 activation were blocked , respectively , by the ERK and inhibitors . Positive_regulation EPHB2 POLDIP2 17495535 1744425 In addition , Inhibition of PI3K , , Raf , and CDK could not *block* the MNNG induced [p-Erk] activation , whereas U0126 and PD98059 abolished it . Positive_regulation EPHB2 POLDIP2 18702686 1950582 We also detected MAPK cross-talk in AGS cells : and JNK inhibitors *increased* [ERK] activation . Positive_regulation EPHB2 POLDIP2 20025124 2175495 Prior treatment of the cells with PD98059 , an [ERK] kinase *inhibitor* or SB203580 , a inhibitor , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation EPHB2 POLDIP2 20054486 2177435 HF6-FC exerts its inhibitory effects by suppression of and NF-kappaB but *activation* of [ERK] . Positive_regulation EPHB2 POLDIP2 23158946 2700104 Icariin promotes differentiation of the mesenchymal stem cells C3H10T1/2 into osteoblasts , and its effect is related to the restraining of [ERK] expression and *activation* of expression in the MAPK signaling pathway . Positive_regulation EPHB2 POLDIP2 24974583 2947617 Treatment of B16F10 cells with U0126 , an [ERK] *inhibitor* , or SB203580 , a inhibitor , suppressed the migration and invasion abilities of B16F10 cells . Positive_regulation EPHB2 POSTN 21885032 2524497 treatment also *induced* [ERK] phosphorylation , and PERIOSTIN induced MMP-2 was reduced by avß3 integrin blocking antibody or ERK inhibitor . Positive_regulation EPHB2 POT1 11956184 953632 cAMP stimulated Ras independent and *dependent* [ERK] phosphorylation and cell proliferation in B-Raf expressing cells , but inhibited growth in B-Raf lacking cells . Positive_regulation EPHB2 POT1 12402047 1009422 We conclude that cAMP induced regulation of [ERK] and *activation* of are independent processes . Positive_regulation EPHB2 POT1 15167895 1259141 ARMS is rapidly tyrosine phosphorylated after binding of neurotrophins to Trk receptors and provides a docking site for the CrkL-C3G complex , resulting in *dependent* sustained [ERK] activation . Positive_regulation EPHB2 POT1 15723799 1376771 Ras independent activation of [ERK] signaling via the torso receptor tyrosine kinase is *mediated* by . Positive_regulation EPHB2 POT1 20877310 2381755 Moreover , we found that negatively *regulated* GNDF induced [ERK] activation and neurite outgrowth . Positive_regulation EPHB2 POT1 24523415 2924180 Moreover , our results showed that NMDA mediated activation of the small G-protein Ras is necessary for PI3K/Akt pathway activation , whereas was *involved* in NMDA phosphorylation of [ERK] . Positive_regulation EPHB2 PPARA 20043140 2192861 Melanogenesis regulating signals , such as mitogen activated protein kinase (MEK)/extracellular signal regulated kinase ( ERK ) , phosphatidylinositol 3-kinase (PI3K)/Akt and p38 mitogen activated protein kinase (MAPK) were evaluated , and [ERK] was *activated* by . Positive_regulation EPHB2 PPARA 20043140 2192862 These results suggest that [ERK] *activation* by contributes to reduced melanin synthesis via ERK signal pathway mediated suppression of MITF and its downstream signal pathway . Positive_regulation EPHB2 PPARG 17065204 1700341 These results are consistent with three pathways through which glitazones may act in effecting metabolic processes ( ammoniagenesis and gluconeogenesis ) as well as cellular growth : 1 ) *dependent* and PPAR-gamma independent pathways , 2 ) [P-ERK] activation , and 3 ) mitochondrial AMPK activation . Positive_regulation EPHB2 PPARG 17597617 1764997 Pro-MMP-2 activation by the agonist , ciglitazone , *induces* cell invasion through the generation of ROS and the activation of [ERK] . Positive_regulation EPHB2 PPARG 19900469 2271983 Among them , [ERK] can be positively/negatively *regulated* by ligands , as in endothelial cells , where TZDs exert anti-inflammatory effects through a novel mechanism involving a rapid inhibition of ERK1/2 phosphorylation/activation . Positive_regulation EPHB2 PPARG 23058985 2698655 Beta-D-glucoside protects against advanced glycation end products ( AGEs ) -mediated diabetic responses by suppressing [ERK] and *inducing* DNA binding . Positive_regulation EPHB2 PPP1R1B 22301787 2560355 is *required* for [MAPK/ERK] signaling in thyroid cells . Positive_regulation EPHB2 PPP1R1B 22753408 2639429 These studies demonstrate that , in D1R expressing MSNs , l-DOPA induced activation of [ERK] and mTORC1 *requires* and indicates the importance of the cAMP/DARPP-32 signaling cascade in dyskinesia . Positive_regulation EPHB2 PPP1R3A 18718181 1951092 Rg1 activated ERK/MAPK pathway by CaMKIIalpha , and the activation of CREB was not only dependent on [ERK] *induced* by , which may provide an explanation for the effect of Rg1 on long-term potentiation . Positive_regulation EPHB2 PPP1R3A 19298253 2056066 could *induce* MEK protein expression and the phosphorylation level of MEK and [ERK] significantly in a time- and dose dependent manner . Positive_regulation EPHB2 PPP2CA 10666504 665615 Okadaic acid completely reversed the ERK inhibition caused by adrenomedullin , suggesting that may be *involved* in the adrenomedullin mediated changes in proliferation , apoptosis and [ERK] activity . Positive_regulation EPHB2 PPP2CA 16477370 1548483 Thus , *regulates* the [ERK] activity in a cell-specific manner , and it is speculated that distinct regulation of PP2A in the ErbB4 receptor signalling pathway may cause a difference in progression of cancer phenotypes . Positive_regulation EPHB2 PPP2CA 18155662 1855211 We found that *regulates* alphaIIbbeta3 control of the [ERK] signaling in a polymorphism specific fashion . Positive_regulation EPHB2 PPP2CA 18272021 1911610 Accordingly , *regulates* acute dose- and time dependent changes in [MEK-ERK-p90RSK] phosphorylation after haloperidol treatment . Positive_regulation EPHB2 PPP2CA 19286927 2063874 We also found that inhibition *resulted* in prolonged activation of JNK , p38 , and [ERK] resulting in both increased transcriptional activation of the IL-8 promoter and posttranscriptional stabilization of IL-8 mRNA . Positive_regulation EPHB2 PPP2CA 21030067 2354441 Inhibition of in benign cells *resulted* in an increase in [ERK] activation and in TGF-ß1 auto-induction after TGF-ß1 ( 10 ng/mL ) treatment . Positive_regulation EPHB2 PPP2CA 24997451 2952746 Forskolin dephosphorylated and activated , impairing proliferation and colonosphere formation , and *inducing* activation of caspase 3/7 and changes in AKT and [ERK] phosphorylation . Positive_regulation EPHB2 PPP2R1A 10666504 665616 Okadaic acid completely reversed the ERK inhibition caused by adrenomedullin , suggesting that may be *involved* in the adrenomedullin mediated changes in proliferation , apoptosis and [ERK] activity . Positive_regulation EPHB2 PPP2R1A 16477370 1548484 Thus , *regulates* the [ERK] activity in a cell-specific manner , and it is speculated that distinct regulation of PP2A in the ErbB4 receptor signalling pathway may cause a difference in progression of cancer phenotypes . Positive_regulation EPHB2 PPP2R1A 18155662 1855212 We found that *regulates* alphaIIbbeta3 control of the [ERK] signaling in a polymorphism specific fashion . Positive_regulation EPHB2 PPP2R1A 18272021 1911611 Accordingly , *regulates* acute dose- and time dependent changes in [MEK-ERK-p90RSK] phosphorylation after haloperidol treatment . Positive_regulation EPHB2 PPP2R1A 19286927 2063875 We also found that inhibition *resulted* in prolonged activation of JNK , p38 , and [ERK] resulting in both increased transcriptional activation of the IL-8 promoter and posttranscriptional stabilization of IL-8 mRNA . Positive_regulation EPHB2 PPP2R1A 21030067 2354442 Inhibition of in benign cells *resulted* in an increase in [ERK] activation and in TGF-ß1 auto-induction after TGF-ß1 ( 10 ng/mL ) treatment . Positive_regulation EPHB2 PPP2R1A 24997451 2952747 Forskolin dephosphorylated and activated , impairing proliferation and colonosphere formation , and *inducing* activation of caspase 3/7 and changes in AKT and [ERK] phosphorylation . Positive_regulation EPHB2 PPP2R2B 10666504 665617 Okadaic acid completely reversed the ERK inhibition caused by adrenomedullin , suggesting that may be *involved* in the adrenomedullin mediated changes in proliferation , apoptosis and [ERK] activity . Positive_regulation EPHB2 PPP2R2B 16477370 1548485 Thus , *regulates* the [ERK] activity in a cell-specific manner , and it is speculated that distinct regulation of PP2A in the ErbB4 receptor signalling pathway may cause a difference in progression of cancer phenotypes . Positive_regulation EPHB2 PPP2R2B 18155662 1855213 We found that *regulates* alphaIIbbeta3 control of the [ERK] signaling in a polymorphism specific fashion . Positive_regulation EPHB2 PPP2R2B 18272021 1911612 Accordingly , *regulates* acute dose- and time dependent changes in [MEK-ERK-p90RSK] phosphorylation after haloperidol treatment . Positive_regulation EPHB2 PPP2R2B 19286927 2063876 We also found that inhibition *resulted* in prolonged activation of JNK , p38 , and [ERK] resulting in both increased transcriptional activation of the IL-8 promoter and posttranscriptional stabilization of IL-8 mRNA . Positive_regulation EPHB2 PPP2R2B 21030067 2354443 Inhibition of in benign cells *resulted* in an increase in [ERK] activation and in TGF-ß1 auto-induction after TGF-ß1 ( 10 ng/mL ) treatment . Positive_regulation EPHB2 PPP2R2B 24997451 2952748 Forskolin dephosphorylated and activated , impairing proliferation and colonosphere formation , and *inducing* activation of caspase 3/7 and changes in AKT and [ERK] phosphorylation . Positive_regulation EPHB2 PPP3CA 15030770 1223171 Unexpectedly , we found that removal of activity from thymocytes *results* in inefficient [ERK] activation at the double positive stage of thymocyte development , when selection occurs . Positive_regulation EPHB2 PPP3CA 18046413 1833048 Analysis of mice deficient in both Bim ( which is required for negative selection ) and calcineurin revealed that *induced* [ERK] ( extracellular signal regulated kinase ) sensitization is required for differentiation in response to ` weak ' positive selecting signals but not in response to ` strong ' negative selecting signals ( which normally induce apoptosis ) . Positive_regulation EPHB2 PPP3CA 18956431 1995051 Stretch induced activation of [ERK] in myocytes is p38 and *dependent* . Positive_regulation EPHB2 PPP3CA 22371971 2561721 Inhibition of further *reduced* the phosphorylation of [ERK] and AKT ( at thr 308 ) and inhibited the activation of Ras , but inhibitors of MAPK or PI3K signaling did not affect the circadian rhythm of calcineurin activity . Positive_regulation EPHB2 PPP3CB 15030770 1223172 Unexpectedly , we found that removal of activity from thymocytes *results* in inefficient [ERK] activation at the double positive stage of thymocyte development , when selection occurs . Positive_regulation EPHB2 PPP3CB 18046413 1833049 Analysis of mice deficient in both Bim ( which is required for negative selection ) and calcineurin revealed that *induced* [ERK] ( extracellular signal regulated kinase ) sensitization is required for differentiation in response to ` weak ' positive selecting signals but not in response to ` strong ' negative selecting signals ( which normally induce apoptosis ) . Positive_regulation EPHB2 PPP3CB 22371971 2561722 Inhibition of further *reduced* the phosphorylation of [ERK] and AKT ( at thr 308 ) and inhibited the activation of Ras , but inhibitors of MAPK or PI3K signaling did not affect the circadian rhythm of calcineurin activity . Positive_regulation EPHB2 PPP3CC 15030770 1223173 Unexpectedly , we found that removal of activity from thymocytes *results* in inefficient [ERK] activation at the double positive stage of thymocyte development , when selection occurs . Positive_regulation EPHB2 PPP3CC 18046413 1833050 Analysis of mice deficient in both Bim ( which is required for negative selection ) and calcineurin revealed that *induced* [ERK] ( extracellular signal regulated kinase ) sensitization is required for differentiation in response to ` weak ' positive selecting signals but not in response to ` strong ' negative selecting signals ( which normally induce apoptosis ) . Positive_regulation EPHB2 PPP3CC 22371971 2561723 Inhibition of further *reduced* the phosphorylation of [ERK] and AKT ( at thr 308 ) and inhibited the activation of Ras , but inhibitors of MAPK or PI3K signaling did not affect the circadian rhythm of calcineurin activity . Positive_regulation EPHB2 PPP3R1 18956431 1995052 Stretch induced activation of [ERK] in myocytes is p38 and *dependent* . Positive_regulation EPHB2 PPP5C 17803971 1795297 Further analyses revealed that both and DPN *increased* [ERK] phosphorylation , however , the temporal profile and magnitude of response were unique to each molecule . Positive_regulation EPHB2 PPP5C 17803971 1795298 The presence of the L-type Ca ( 2+ ) channel inhibitor , nifedipine ( 10 microM ) , partially inhibited 17beta-estradiol- and *induced* increase in phosphorylated [ERK] expression , whereas it induced a complete inhibition of DPN induced increase in ERK phosphorylation . Positive_regulation EPHB2 PRDX2 23201405 2730739 In parallel , hypoxia and synergistically *increased* [p-ERK] and p-Akt without effecting VEGF-A level . Positive_regulation EPHB2 PRDX2 23951179 2831693 We determined that *increased* basal [ERK] phosphorylation , and attenuated TZD mediated suppression of TNFa induced ERK phosphorylation , consistent with TSA 's effects on lipolysis . Positive_regulation EPHB2 PRDX2 23951179 2831694 These studies suggest that , through down regulating PPAR? , *attenuates* TZD mediated suppression of TNFa induced [ERK] phosphorylation and lipolysis in adipocytes . Positive_regulation EPHB2 PRKAA1 11262401 818803 Activation of by AICAR in NIH-3T3 cells *resulted* in drastic inhibitions of Ras , Raf-1 , and [Erk] activation induced by insulin-like growth factor 1 (IGF-1) . Positive_regulation EPHB2 PRKAA1 11978788 954045 In rat extensor digitorum longus (EDL) muscles , ( a ) activator , 5-aminoimidazole-4-carboxamide-1-beta-d-riboside ( AICAR ) , *activated* PYK2 , [ERK] and aPKCs ; Positive_regulation EPHB2 PRKAA1 18243130 1871427 Conversely , activation of by AICAR also showed a significant inhibition of basal and serum *induced* [ERK] phosphorylation but it showed a delayed and steadfast inhibition which appeared after 60min and lasted until 12h . Positive_regulation EPHB2 PRKAA1 19520853 2116051 *Activation* of [MEK/ERK] by upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation EPHB2 PRKAA1 20231899 2223820 Finally , the extracellular stresses caused by glucose deprivation or aminoimidazole carboxamide ribonucleotide ( AICAR ; AMPK activator ) regulate ( 14 ) C-glucose uptake and cell surface glucose transport (GLUT) 4 through [ERK] *stimulation* by mediated PLD1 activation . Positive_regulation EPHB2 PRKAA1 21678424 2532110 In addition , inhibition or knockdown of during osteogenesis *inhibited* [ERK] phosphorylation , which is required for osteogenesis . Positive_regulation EPHB2 PRKAA1 22269797 2559876 Our results demonstrate that resveratrol profoundly inhibits [ERK] and mTOR signaling in sensory neurons in a time- and concentration dependent fashion and that these effects are *mediated* by activation and independent of sirtuin activity . Positive_regulation EPHB2 PRKAA1 22576211 2598072 We further show that targets the dual-specificity protein phosphatase DUSP6 for degradation and this *increases* [ERK] activity , which then upregulates the VEGF-A protein . Positive_regulation EPHB2 PRKAA1 23707617 2806316 More importantly , activation of [ERK] induced by uric acid is significantly *diminished* by inhibitor , indicating ERK as a downstream target of AMPK in response to high uric acid condition . Positive_regulation EPHB2 PRKAA2 11262401 818804 Activation of by AICAR in NIH-3T3 cells *resulted* in drastic inhibitions of Ras , Raf-1 , and [Erk] activation induced by insulin-like growth factor 1 (IGF-1) . Positive_regulation EPHB2 PRKAA2 11978788 954046 In rat extensor digitorum longus (EDL) muscles , ( a ) activator , 5-aminoimidazole-4-carboxamide-1-beta-d-riboside ( AICAR ) , *activated* PYK2 , [ERK] and aPKCs ; Positive_regulation EPHB2 PRKAA2 18243130 1871428 Conversely , activation of by AICAR also showed a significant inhibition of basal and serum *induced* [ERK] phosphorylation but it showed a delayed and steadfast inhibition which appeared after 60min and lasted until 12h . Positive_regulation EPHB2 PRKAA2 19520853 2116052 *Activation* of [MEK/ERK] by upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation EPHB2 PRKAA2 20231899 2223821 Finally , the extracellular stresses caused by glucose deprivation or aminoimidazole carboxamide ribonucleotide ( AICAR ; AMPK activator ) regulate ( 14 ) C-glucose uptake and cell surface glucose transport (GLUT) 4 through [ERK] *stimulation* by mediated PLD1 activation . Positive_regulation EPHB2 PRKAA2 21678424 2532111 In addition , inhibition or knockdown of during osteogenesis *inhibited* [ERK] phosphorylation , which is required for osteogenesis . Positive_regulation EPHB2 PRKAA2 22269797 2559877 Our results demonstrate that resveratrol profoundly inhibits [ERK] and mTOR signaling in sensory neurons in a time- and concentration dependent fashion and that these effects are *mediated* by activation and independent of sirtuin activity . Positive_regulation EPHB2 PRKAA2 22576211 2598073 We further show that targets the dual-specificity protein phosphatase DUSP6 for degradation and this *increases* [ERK] activity , which then upregulates the VEGF-A protein . Positive_regulation EPHB2 PRKAA2 23707617 2806317 More importantly , activation of [ERK] induced by uric acid is significantly *diminished* by inhibitor , indicating ERK as a downstream target of AMPK in response to high uric acid condition . Positive_regulation EPHB2 PRKAB1 11262401 818805 Activation of by AICAR in NIH-3T3 cells *resulted* in drastic inhibitions of Ras , Raf-1 , and [Erk] activation induced by insulin-like growth factor 1 (IGF-1) . Positive_regulation EPHB2 PRKAB1 11978788 954047 In rat extensor digitorum longus (EDL) muscles , ( a ) activator , 5-aminoimidazole-4-carboxamide-1-beta-d-riboside ( AICAR ) , *activated* PYK2 , [ERK] and aPKCs ; Positive_regulation EPHB2 PRKAB1 18243130 1871429 Conversely , activation of by AICAR also showed a significant inhibition of basal and serum *induced* [ERK] phosphorylation but it showed a delayed and steadfast inhibition which appeared after 60min and lasted until 12h . Positive_regulation EPHB2 PRKAB1 19520853 2116053 *Activation* of [MEK/ERK] by upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation EPHB2 PRKAB1 20231899 2223822 Finally , the extracellular stresses caused by glucose deprivation or aminoimidazole carboxamide ribonucleotide ( AICAR ; AMPK activator ) regulate ( 14 ) C-glucose uptake and cell surface glucose transport (GLUT) 4 through [ERK] *stimulation* by mediated PLD1 activation . Positive_regulation EPHB2 PRKAB1 21678424 2532112 In addition , inhibition or knockdown of during osteogenesis *inhibited* [ERK] phosphorylation , which is required for osteogenesis . Positive_regulation EPHB2 PRKAB1 22269797 2559878 Our results demonstrate that resveratrol profoundly inhibits [ERK] and mTOR signaling in sensory neurons in a time- and concentration dependent fashion and that these effects are *mediated* by activation and independent of sirtuin activity . Positive_regulation EPHB2 PRKAB1 22576211 2598074 We further show that targets the dual-specificity protein phosphatase DUSP6 for degradation and this *increases* [ERK] activity , which then upregulates the VEGF-A protein . Positive_regulation EPHB2 PRKAB1 23707617 2806318 More importantly , activation of [ERK] induced by uric acid is significantly *diminished* by inhibitor , indicating ERK as a downstream target of AMPK in response to high uric acid condition . Positive_regulation EPHB2 PRKAB2 11262401 818806 Activation of by AICAR in NIH-3T3 cells *resulted* in drastic inhibitions of Ras , Raf-1 , and [Erk] activation induced by insulin-like growth factor 1 (IGF-1) . Positive_regulation EPHB2 PRKAB2 11978788 954048 In rat extensor digitorum longus (EDL) muscles , ( a ) activator , 5-aminoimidazole-4-carboxamide-1-beta-d-riboside ( AICAR ) , *activated* PYK2 , [ERK] and aPKCs ; Positive_regulation EPHB2 PRKAB2 18243130 1871430 Conversely , activation of by AICAR also showed a significant inhibition of basal and serum *induced* [ERK] phosphorylation but it showed a delayed and steadfast inhibition which appeared after 60min and lasted until 12h . Positive_regulation EPHB2 PRKAB2 19520853 2116054 *Activation* of [MEK/ERK] by upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation EPHB2 PRKAB2 20231899 2223823 Finally , the extracellular stresses caused by glucose deprivation or aminoimidazole carboxamide ribonucleotide ( AICAR ; AMPK activator ) regulate ( 14 ) C-glucose uptake and cell surface glucose transport (GLUT) 4 through [ERK] *stimulation* by mediated PLD1 activation . Positive_regulation EPHB2 PRKAB2 21678424 2532113 In addition , inhibition or knockdown of during osteogenesis *inhibited* [ERK] phosphorylation , which is required for osteogenesis . Positive_regulation EPHB2 PRKAB2 22269797 2559879 Our results demonstrate that resveratrol profoundly inhibits [ERK] and mTOR signaling in sensory neurons in a time- and concentration dependent fashion and that these effects are *mediated* by activation and independent of sirtuin activity . Positive_regulation EPHB2 PRKAB2 22576211 2598075 We further show that targets the dual-specificity protein phosphatase DUSP6 for degradation and this *increases* [ERK] activity , which then upregulates the VEGF-A protein . Positive_regulation EPHB2 PRKAB2 23707617 2806319 More importantly , activation of [ERK] induced by uric acid is significantly *diminished* by inhibitor , indicating ERK as a downstream target of AMPK in response to high uric acid condition . Positive_regulation EPHB2 PRKACB 10903877 713257 Activation of by 8-bromo-cyclic AMP or forskolin , and inhibition of PKC by calphostin C , *resulted* in a significant decrease in 3TP activity as well as in vitro [ERK] kinase activity in CRAC . Positive_regulation EPHB2 PRKACB 11517300 851412 We conclude that glucagon induced MEK1/2 and ERK1/2 activation is mediated by and that an increase in intracellular calcium concentration is *required* for maximal [ERK] activation . Positive_regulation EPHB2 PRKACB 11901221 921912 [ERK] activation through both TPalpha and TPbeta was *dependent* on and phosphoinositide 3-kinase (PI3K) class 1 ( A ) , but not class 1 ( B ) , and was modulated by Harvey-Ras , A-Raf , c-Raf , and Rap1B/B-Raf and also involved transactivation of the epidermal growth factor receptor . Positive_regulation EPHB2 PRKACB 12036966 968319 For the beta ( 2 ) AR in HEK-293 cells , where activity is *required* for [ERK] activation , expression of GsCT caused a net inhibition of ERK activation . Positive_regulation EPHB2 PRKACB 12473665 1055932 However , PACAP induced GTP loading of Rap1 was not sufficient to account for ERK activation by PACAP because 1 ) PACAP elicited Rap1 GTP loading depended only on phospholipase C , whereas maximal stimulation of [ERK] by PACAP also *required* the activity of , protein kinase C ( PKC ) , and calcium dependent signaling ; Positive_regulation EPHB2 PRKACB 12706116 1082492 However , activity was also not *necessary* for the early translocation of [Erk] into the nucleus by NGF or Ras , but it was able to induce a small influx of Erk that could be measured with GFP-Erk2 . Positive_regulation EPHB2 PRKACB 14597235 1160462 Moreover , activity is *required* for depolarization induced Rap1 activation and full [Erk] stimulation , but is not involved in that of Ras . Positive_regulation EPHB2 PRKACB 14988413 1236708 We conclude that glucagon induced ERK1/2 activation is mediated by and that an increase in [ Ca ( 2+ ) ] ( i ) is *required* for maximal [ERK] activation . Positive_regulation EPHB2 PRKACB 15385614 1300139 The [ERK] activation produced by capsaicin is totally *suppressed* by inhibition of either or PKC . Positive_regulation EPHB2 PRKACB 16030021 1459484 Knockdown of PDE4D , but not PDE4B , amplifies isoprenaline stimulated phosphorylation of the beta2-adrenergic receptor (beta2-AR) by and *activation* of extracellular signal regulated kinase ( [ERK] ) through G ( i ) . Positive_regulation EPHB2 PRKACB 16098594 1507117 Consequently , the inhibitor *down-regulated* [ERK] and p38 MAPK , and decreased cell proliferation . Positive_regulation EPHB2 PRKACB 16098594 1507279 However , the treatment of LPS stimulated 38B9 cells with pertussis toxin (PTX) , an inhibitor for the G protein coupled receptor , inhibited the activation of both PKC- and *dependent* [ERK] and significantly reduced LPS induced proliferation but not IgG secretion . Positive_regulation EPHB2 PRKACB 16246112 1471500 Beta-arrestin recruited phosphodiesterase-4 desensitizes the *mediated* switching of beta2-adrenoceptor signalling to activation of [ERK] . Positive_regulation EPHB2 PRKACB 16452469 1540577 Pharmacological inhibition of cAMP dependent protein kinase (PKA) and siRNA mediated depletion of PKA greatly reduced B-Raf activity , ERK1/2 activation , and cell proliferation in ( WT ) B-Raf cells , whereas it did not affect ( V600E ) B-Raf cells , demonstrating a key *role* of in mediating ( WT ) [B-Raf/ERK] signaling for uveal melanoma cell growth . Positive_regulation EPHB2 PRKACB 16452469 1540607 This ruled out a role for Rap1 in the mediated [B-Raf/ERK] *activation* in ( WT ) B-Raf cells . Positive_regulation EPHB2 PRKACB 16887887 1632402 Galpha ( s ) *dependent* [ERK] activation was rapid , transient , and blocked by H89 ( a PKA inhibitor ) , but it was insensitive to small interfering RNA mediated depletion of beta-arrestins . Positive_regulation EPHB2 PRKACB 19279268 2046347 Upstream , NMDA receptor , adenylyl cyclase ( AC ) and activators *activated* [ERK] in rACC slices . Positive_regulation EPHB2 PRKACB 20808799 2314279 We here studied , in the gold-standard non-human primate model of Parkinson 's disease , the changes in *dependent* phosphorylation of DARPP-32 and GluR1 AMPA receptor , as well as in [ERK] and ribosomal protein S6 ( S6 ) phosphorylation , associated to acute and chronic administration of L-DOPA . Positive_regulation EPHB2 PRKACB 21518335 2567456 The Phase II ( 5-10 min ) rapid decline in [ERK] phosphorylation *involves* inhibition and serine/threonine phosphatase PP1/PP2A activation . Positive_regulation EPHB2 PRKACB 22493291 2601762 Moreover , the NMU induced [p-ERK] increase was *attenuated* by inhibition and activation of PKA by foskolin would mimic the NMU induced I ( A ) increase . Positive_regulation EPHB2 PRKACB 22653837 2700848 Cyclic dependent paradoxical *activation* of [Raf/MEK/ERK] signaling in polycystin-2 defective mice treated with sorafenib . Positive_regulation EPHB2 PRKACB 9808472 545216 Interestingly , the Ca2+ induced nuclear translocation of [ERK] and Rsk2 to the nucleus *requires* activation . Positive_regulation EPHB2 PRKACG 10903877 713258 Activation of by 8-bromo-cyclic AMP or forskolin , and inhibition of PKC by calphostin C , *resulted* in a significant decrease in 3TP activity as well as in vitro [ERK] kinase activity in CRAC . Positive_regulation EPHB2 PRKACG 11517300 851413 We conclude that glucagon induced MEK1/2 and ERK1/2 activation is mediated by and that an increase in intracellular calcium concentration is *required* for maximal [ERK] activation . Positive_regulation EPHB2 PRKACG 11901221 921913 [ERK] activation through both TPalpha and TPbeta was *dependent* on and phosphoinositide 3-kinase (PI3K) class 1 ( A ) , but not class 1 ( B ) , and was modulated by Harvey-Ras , A-Raf , c-Raf , and Rap1B/B-Raf and also involved transactivation of the epidermal growth factor receptor . Positive_regulation EPHB2 PRKACG 12036966 968320 For the beta ( 2 ) AR in HEK-293 cells , where activity is *required* for [ERK] activation , expression of GsCT caused a net inhibition of ERK activation . Positive_regulation EPHB2 PRKACG 12473665 1055933 However , PACAP induced GTP loading of Rap1 was not sufficient to account for ERK activation by PACAP because 1 ) PACAP elicited Rap1 GTP loading depended only on phospholipase C , whereas maximal stimulation of [ERK] by PACAP also *required* the activity of , protein kinase C ( PKC ) , and calcium dependent signaling ; Positive_regulation EPHB2 PRKACG 12706116 1082493 However , activity was also not *necessary* for the early translocation of [Erk] into the nucleus by NGF or Ras , but it was able to induce a small influx of Erk that could be measured with GFP-Erk2 . Positive_regulation EPHB2 PRKACG 14597235 1160463 Moreover , activity is *required* for depolarization induced Rap1 activation and full [Erk] stimulation , but is not involved in that of Ras . Positive_regulation EPHB2 PRKACG 14988413 1236709 We conclude that glucagon induced ERK1/2 activation is mediated by and that an increase in [ Ca ( 2+ ) ] ( i ) is *required* for maximal [ERK] activation . Positive_regulation EPHB2 PRKACG 15385614 1300140 The [ERK] activation produced by capsaicin is totally *suppressed* by inhibition of either or PKC . Positive_regulation EPHB2 PRKACG 16030021 1459485 Knockdown of PDE4D , but not PDE4B , amplifies isoprenaline stimulated phosphorylation of the beta2-adrenergic receptor (beta2-AR) by and *activation* of extracellular signal regulated kinase ( [ERK] ) through G ( i ) . Positive_regulation EPHB2 PRKACG 16098594 1507118 Consequently , the inhibitor *down-regulated* [ERK] and p38 MAPK , and decreased cell proliferation . Positive_regulation EPHB2 PRKACG 16098594 1507280 However , the treatment of LPS stimulated 38B9 cells with pertussis toxin (PTX) , an inhibitor for the G protein coupled receptor , inhibited the activation of both PKC- and *dependent* [ERK] and significantly reduced LPS induced proliferation but not IgG secretion . Positive_regulation EPHB2 PRKACG 16246112 1471501 Beta-arrestin recruited phosphodiesterase-4 desensitizes the *mediated* switching of beta2-adrenoceptor signalling to activation of [ERK] . Positive_regulation EPHB2 PRKACG 16452469 1540578 Pharmacological inhibition of cAMP dependent protein kinase (PKA) and siRNA mediated depletion of PKA greatly reduced B-Raf activity , ERK1/2 activation , and cell proliferation in ( WT ) B-Raf cells , whereas it did not affect ( V600E ) B-Raf cells , demonstrating a key *role* of in mediating ( WT ) [B-Raf/ERK] signaling for uveal melanoma cell growth . Positive_regulation EPHB2 PRKACG 16452469 1540608 This ruled out a role for Rap1 in the *mediated* [B-Raf/ERK] activation in ( WT ) B-Raf cells . Positive_regulation EPHB2 PRKACG 16887887 1632403 Galpha ( s ) dependent [ERK] *activation* was rapid , transient , and blocked by H89 ( a PKA inhibitor ) , but it was insensitive to small interfering RNA mediated depletion of beta-arrestins . Positive_regulation EPHB2 PRKACG 19279268 2046348 Upstream , NMDA receptor , adenylyl cyclase ( AC ) and activators *activated* [ERK] in rACC slices . Positive_regulation EPHB2 PRKACG 20808799 2314280 We here studied , in the gold-standard non-human primate model of Parkinson 's disease , the changes in *dependent* phosphorylation of DARPP-32 and GluR1 AMPA receptor , as well as in [ERK] and ribosomal protein S6 ( S6 ) phosphorylation , associated to acute and chronic administration of L-DOPA . Positive_regulation EPHB2 PRKACG 21518335 2567457 The Phase II ( 5-10 min ) rapid decline in [ERK] phosphorylation *involves* inhibition and serine/threonine phosphatase PP1/PP2A activation . Positive_regulation EPHB2 PRKACG 22493291 2601763 Moreover , the NMU induced [p-ERK] increase was *attenuated* by inhibition and activation of PKA by foskolin would mimic the NMU induced I ( A ) increase . Positive_regulation EPHB2 PRKACG 22653837 2700849 Cyclic *dependent* paradoxical activation of [Raf/MEK/ERK] signaling in polycystin-2 defective mice treated with sorafenib . Positive_regulation EPHB2 PRKACG 9808472 545217 Interestingly , the Ca2+ induced nuclear translocation of [ERK] and Rsk2 to the nucleus *requires* activation . Positive_regulation EPHB2 PRKAG1 11262401 818807 Activation of by AICAR in NIH-3T3 cells *resulted* in drastic inhibitions of Ras , Raf-1 , and [Erk] activation induced by insulin-like growth factor 1 (IGF-1) . Positive_regulation EPHB2 PRKAG1 11978788 954049 In rat extensor digitorum longus (EDL) muscles , ( a ) activator , 5-aminoimidazole-4-carboxamide-1-beta-d-riboside ( AICAR ) , *activated* PYK2 , [ERK] and aPKCs ; Positive_regulation EPHB2 PRKAG1 18243130 1871431 Conversely , activation of by AICAR also showed a significant inhibition of basal and serum *induced* [ERK] phosphorylation but it showed a delayed and steadfast inhibition which appeared after 60min and lasted until 12h . Positive_regulation EPHB2 PRKAG1 19520853 2116055 *Activation* of [MEK/ERK] by upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation EPHB2 PRKAG1 20231899 2223824 Finally , the extracellular stresses caused by glucose deprivation or aminoimidazole carboxamide ribonucleotide ( AICAR ; AMPK activator ) regulate ( 14 ) C-glucose uptake and cell surface glucose transport (GLUT) 4 through [ERK] *stimulation* by mediated PLD1 activation . Positive_regulation EPHB2 PRKAG1 21678424 2532114 In addition , inhibition or knockdown of during osteogenesis *inhibited* [ERK] phosphorylation , which is required for osteogenesis . Positive_regulation EPHB2 PRKAG1 22269797 2559880 Our results demonstrate that resveratrol profoundly inhibits [ERK] and mTOR signaling in sensory neurons in a time- and concentration dependent fashion and that these effects are *mediated* by activation and independent of sirtuin activity . Positive_regulation EPHB2 PRKAG1 22576211 2598076 We further show that targets the dual-specificity protein phosphatase DUSP6 for degradation and this *increases* [ERK] activity , which then upregulates the VEGF-A protein . Positive_regulation EPHB2 PRKAG1 23707617 2806320 More importantly , activation of [ERK] induced by uric acid is significantly *diminished* by inhibitor , indicating ERK as a downstream target of AMPK in response to high uric acid condition . Positive_regulation EPHB2 PRKAG2 11262401 818808 Activation of by AICAR in NIH-3T3 cells *resulted* in drastic inhibitions of Ras , Raf-1 , and [Erk] activation induced by insulin-like growth factor 1 (IGF-1) . Positive_regulation EPHB2 PRKAG2 11978788 954050 In rat extensor digitorum longus (EDL) muscles , ( a ) activator , 5-aminoimidazole-4-carboxamide-1-beta-d-riboside ( AICAR ) , *activated* PYK2 , [ERK] and aPKCs ; Positive_regulation EPHB2 PRKAG2 18243130 1871432 Conversely , activation of by AICAR also showed a significant inhibition of basal and serum *induced* [ERK] phosphorylation but it showed a delayed and steadfast inhibition which appeared after 60min and lasted until 12h . Positive_regulation EPHB2 PRKAG2 19520853 2116056 *Activation* of [MEK/ERK] by upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation EPHB2 PRKAG2 20231899 2223825 Finally , the extracellular stresses caused by glucose deprivation or aminoimidazole carboxamide ribonucleotide ( AICAR ; AMPK activator ) regulate ( 14 ) C-glucose uptake and cell surface glucose transport (GLUT) 4 through [ERK] *stimulation* by mediated PLD1 activation . Positive_regulation EPHB2 PRKAG2 21678424 2532115 In addition , inhibition or knockdown of during osteogenesis *inhibited* [ERK] phosphorylation , which is required for osteogenesis . Positive_regulation EPHB2 PRKAG2 22269797 2559881 Our results demonstrate that resveratrol profoundly inhibits [ERK] and mTOR signaling in sensory neurons in a time- and concentration dependent fashion and that these effects are *mediated* by activation and independent of sirtuin activity . Positive_regulation EPHB2 PRKAG2 22576211 2598077 We further show that targets the dual-specificity protein phosphatase DUSP6 for degradation and this *increases* [ERK] activity , which then upregulates the VEGF-A protein . Positive_regulation EPHB2 PRKAG2 23707617 2806321 More importantly , activation of [ERK] induced by uric acid is significantly *diminished* by inhibitor , indicating ERK as a downstream target of AMPK in response to high uric acid condition . Positive_regulation EPHB2 PRKAR1A 10903877 713259 Activation of by 8-bromo-cyclic AMP or forskolin , and inhibition of PKC by calphostin C , *resulted* in a significant decrease in 3TP activity as well as in vitro [ERK] kinase activity in CRAC . Positive_regulation EPHB2 PRKAR1A 11517300 851414 We conclude that glucagon induced MEK1/2 and ERK1/2 activation is mediated by and that an increase in intracellular calcium concentration is *required* for maximal [ERK] activation . Positive_regulation EPHB2 PRKAR1A 11901221 921914 [ERK] activation through both TPalpha and TPbeta was *dependent* on and phosphoinositide 3-kinase (PI3K) class 1 ( A ) , but not class 1 ( B ) , and was modulated by Harvey-Ras , A-Raf , c-Raf , and Rap1B/B-Raf and also involved transactivation of the epidermal growth factor receptor . Positive_regulation EPHB2 PRKAR1A 12036966 968321 For the beta ( 2 ) AR in HEK-293 cells , where activity is *required* for [ERK] activation , expression of GsCT caused a net inhibition of ERK activation . Positive_regulation EPHB2 PRKAR1A 12473665 1055934 However , PACAP induced GTP loading of Rap1 was not sufficient to account for ERK activation by PACAP because 1 ) PACAP elicited Rap1 GTP loading depended only on phospholipase C , whereas maximal stimulation of [ERK] by PACAP also *required* the activity of , protein kinase C ( PKC ) , and calcium dependent signaling ; Positive_regulation EPHB2 PRKAR1A 12706116 1082494 However , activity was also not *necessary* for the early translocation of [Erk] into the nucleus by NGF or Ras , but it was able to induce a small influx of Erk that could be measured with GFP-Erk2 . Positive_regulation EPHB2 PRKAR1A 14597235 1160464 Moreover , activity is *required* for depolarization induced Rap1 activation and full [Erk] stimulation , but is not involved in that of Ras . Positive_regulation EPHB2 PRKAR1A 14988413 1236710 We conclude that glucagon induced ERK1/2 activation is mediated by and that an increase in [ Ca ( 2+ ) ] ( i ) is *required* for maximal [ERK] activation . Positive_regulation EPHB2 PRKAR1A 15385614 1300141 The [ERK] activation produced by capsaicin is totally *suppressed* by inhibition of either or PKC . Positive_regulation EPHB2 PRKAR1A 16030021 1459486 Knockdown of PDE4D , but not PDE4B , amplifies isoprenaline stimulated phosphorylation of the beta2-adrenergic receptor (beta2-AR) by and *activation* of extracellular signal regulated kinase ( [ERK] ) through G ( i ) . Positive_regulation EPHB2 PRKAR1A 16098594 1507119 Consequently , the inhibitor *down-regulated* [ERK] and p38 MAPK , and decreased cell proliferation . Positive_regulation EPHB2 PRKAR1A 16098594 1507281 However , the treatment of LPS stimulated 38B9 cells with pertussis toxin (PTX) , an inhibitor for the G protein coupled receptor , inhibited the activation of both PKC- and *dependent* [ERK] and significantly reduced LPS induced proliferation but not IgG secretion . Positive_regulation EPHB2 PRKAR1A 16246112 1471502 Beta-arrestin recruited phosphodiesterase-4 desensitizes the *mediated* switching of beta2-adrenoceptor signalling to activation of [ERK] . Positive_regulation EPHB2 PRKAR1A 16452469 1540579 Pharmacological inhibition of cAMP dependent protein kinase (PKA) and siRNA mediated depletion of PKA greatly reduced B-Raf activity , ERK1/2 activation , and cell proliferation in ( WT ) B-Raf cells , whereas it did not affect ( V600E ) B-Raf cells , demonstrating a key *role* of in mediating ( WT ) [B-Raf/ERK] signaling for uveal melanoma cell growth . Positive_regulation EPHB2 PRKAR1A 16452469 1540609 This ruled out a role for Rap1 in the mediated [B-Raf/ERK] *activation* in ( WT ) B-Raf cells . Positive_regulation EPHB2 PRKAR1A 16887887 1632404 Galpha ( s ) dependent [ERK] *activation* was rapid , transient , and blocked by H89 ( a PKA inhibitor ) , but it was insensitive to small interfering RNA mediated depletion of beta-arrestins . Positive_regulation EPHB2 PRKAR1A 19279268 2046349 Upstream , NMDA receptor , adenylyl cyclase ( AC ) and activators *activated* [ERK] in rACC slices . Positive_regulation EPHB2 PRKAR1A 20808799 2314281 We here studied , in the gold-standard non-human primate model of Parkinson 's disease , the changes in *dependent* phosphorylation of DARPP-32 and GluR1 AMPA receptor , as well as in [ERK] and ribosomal protein S6 ( S6 ) phosphorylation , associated to acute and chronic administration of L-DOPA . Positive_regulation EPHB2 PRKAR1A 21518335 2567458 The Phase II ( 5-10 min ) rapid decline in [ERK] phosphorylation *involves* inhibition and serine/threonine phosphatase PP1/PP2A activation . Positive_regulation EPHB2 PRKAR1A 22493291 2601764 Moreover , the NMU induced [p-ERK] increase was *attenuated* by inhibition and activation of PKA by foskolin would mimic the NMU induced I ( A ) increase . Positive_regulation EPHB2 PRKAR1A 22653837 2700850 Cyclic dependent paradoxical *activation* of [Raf/MEK/ERK] signaling in polycystin-2 defective mice treated with sorafenib . Positive_regulation EPHB2 PRKAR1A 9808472 545218 Interestingly , the Ca2+ induced nuclear translocation of [ERK] and Rsk2 to the nucleus *requires* activation . Positive_regulation EPHB2 PRKAR1B 10903877 713260 Activation of by 8-bromo-cyclic AMP or forskolin , and inhibition of PKC by calphostin C , *resulted* in a significant decrease in 3TP activity as well as in vitro [ERK] kinase activity in CRAC . Positive_regulation EPHB2 PRKAR1B 11517300 851415 We conclude that glucagon induced MEK1/2 and ERK1/2 activation is mediated by and that an increase in intracellular calcium concentration is *required* for maximal [ERK] activation . Positive_regulation EPHB2 PRKAR1B 11901221 921915 [ERK] activation through both TPalpha and TPbeta was *dependent* on and phosphoinositide 3-kinase (PI3K) class 1 ( A ) , but not class 1 ( B ) , and was modulated by Harvey-Ras , A-Raf , c-Raf , and Rap1B/B-Raf and also involved transactivation of the epidermal growth factor receptor . Positive_regulation EPHB2 PRKAR1B 12036966 968322 For the beta ( 2 ) AR in HEK-293 cells , where activity is *required* for [ERK] activation , expression of GsCT caused a net inhibition of ERK activation . Positive_regulation EPHB2 PRKAR1B 12473665 1055935 However , PACAP induced GTP loading of Rap1 was not sufficient to account for ERK activation by PACAP because 1 ) PACAP elicited Rap1 GTP loading depended only on phospholipase C , whereas maximal stimulation of [ERK] by PACAP also *required* the activity of , protein kinase C ( PKC ) , and calcium dependent signaling ; Positive_regulation EPHB2 PRKAR1B 12706116 1082495 However , activity was also not *necessary* for the early translocation of [Erk] into the nucleus by NGF or Ras , but it was able to induce a small influx of Erk that could be measured with GFP-Erk2 . Positive_regulation EPHB2 PRKAR1B 14597235 1160465 Moreover , activity is *required* for depolarization induced Rap1 activation and full [Erk] stimulation , but is not involved in that of Ras . Positive_regulation EPHB2 PRKAR1B 14988413 1236711 We conclude that glucagon induced ERK1/2 activation is mediated by and that an increase in [ Ca ( 2+ ) ] ( i ) is *required* for maximal [ERK] activation . Positive_regulation EPHB2 PRKAR1B 15385614 1300142 The [ERK] activation produced by capsaicin is totally *suppressed* by inhibition of either or PKC . Positive_regulation EPHB2 PRKAR1B 16030021 1459487 Knockdown of PDE4D , but not PDE4B , amplifies isoprenaline stimulated phosphorylation of the beta2-adrenergic receptor (beta2-AR) by and *activation* of extracellular signal regulated kinase ( [ERK] ) through G ( i ) . Positive_regulation EPHB2 PRKAR1B 16098594 1507120 Consequently , the inhibitor *down-regulated* [ERK] and p38 MAPK , and decreased cell proliferation . Positive_regulation EPHB2 PRKAR1B 16098594 1507282 However , the treatment of LPS stimulated 38B9 cells with pertussis toxin (PTX) , an inhibitor for the G protein coupled receptor , inhibited the activation of both PKC- and *dependent* [ERK] and significantly reduced LPS induced proliferation but not IgG secretion . Positive_regulation EPHB2 PRKAR1B 16246112 1471503 Beta-arrestin recruited phosphodiesterase-4 desensitizes the *mediated* switching of beta2-adrenoceptor signalling to activation of [ERK] . Positive_regulation EPHB2 PRKAR1B 16452469 1540580 Pharmacological inhibition of cAMP dependent protein kinase (PKA) and siRNA mediated depletion of PKA greatly reduced B-Raf activity , ERK1/2 activation , and cell proliferation in ( WT ) B-Raf cells , whereas it did not affect ( V600E ) B-Raf cells , demonstrating a key *role* of in mediating ( WT ) [B-Raf/ERK] signaling for uveal melanoma cell growth . Positive_regulation EPHB2 PRKAR1B 16452469 1540610 This ruled out a role for Rap1 in the *mediated* [B-Raf/ERK] activation in ( WT ) B-Raf cells . Positive_regulation EPHB2 PRKAR1B 16887887 1632405 Galpha ( s ) *dependent* [ERK] activation was rapid , transient , and blocked by H89 ( a PKA inhibitor ) , but it was insensitive to small interfering RNA mediated depletion of beta-arrestins . Positive_regulation EPHB2 PRKAR1B 19279268 2046350 Upstream , NMDA receptor , adenylyl cyclase ( AC ) and activators *activated* [ERK] in rACC slices . Positive_regulation EPHB2 PRKAR1B 20808799 2314282 We here studied , in the gold-standard non-human primate model of Parkinson 's disease , the changes in *dependent* phosphorylation of DARPP-32 and GluR1 AMPA receptor , as well as in [ERK] and ribosomal protein S6 ( S6 ) phosphorylation , associated to acute and chronic administration of L-DOPA . Positive_regulation EPHB2 PRKAR1B 21518335 2567459 The Phase II ( 5-10 min ) rapid decline in [ERK] phosphorylation *involves* inhibition and serine/threonine phosphatase PP1/PP2A activation . Positive_regulation EPHB2 PRKAR1B 22493291 2601765 Moreover , the NMU induced [p-ERK] increase was *attenuated* by inhibition and activation of PKA by foskolin would mimic the NMU induced I ( A ) increase . Positive_regulation EPHB2 PRKAR1B 22653837 2700851 Cyclic *dependent* paradoxical activation of [Raf/MEK/ERK] signaling in polycystin-2 defective mice treated with sorafenib . Positive_regulation EPHB2 PRKAR1B 9808472 545219 Interestingly , the Ca2+ induced nuclear translocation of [ERK] and Rsk2 to the nucleus *requires* activation . Positive_regulation EPHB2 PRKAR2A 10903877 713261 Activation of by 8-bromo-cyclic AMP or forskolin , and inhibition of PKC by calphostin C , *resulted* in a significant decrease in 3TP activity as well as in vitro [ERK] kinase activity in CRAC . Positive_regulation EPHB2 PRKAR2A 11517300 851416 We conclude that glucagon induced MEK1/2 and ERK1/2 activation is mediated by and that an increase in intracellular calcium concentration is *required* for maximal [ERK] activation . Positive_regulation EPHB2 PRKAR2A 11901221 921916 [ERK] activation through both TPalpha and TPbeta was *dependent* on and phosphoinositide 3-kinase (PI3K) class 1 ( A ) , but not class 1 ( B ) , and was modulated by Harvey-Ras , A-Raf , c-Raf , and Rap1B/B-Raf and also involved transactivation of the epidermal growth factor receptor . Positive_regulation EPHB2 PRKAR2A 12036966 968323 For the beta ( 2 ) AR in HEK-293 cells , where activity is *required* for [ERK] activation , expression of GsCT caused a net inhibition of ERK activation . Positive_regulation EPHB2 PRKAR2A 12473665 1055936 However , PACAP induced GTP loading of Rap1 was not sufficient to account for ERK activation by PACAP because 1 ) PACAP elicited Rap1 GTP loading depended only on phospholipase C , whereas maximal stimulation of [ERK] by PACAP also *required* the activity of , protein kinase C ( PKC ) , and calcium dependent signaling ; Positive_regulation EPHB2 PRKAR2A 12706116 1082496 However , activity was also not *necessary* for the early translocation of [Erk] into the nucleus by NGF or Ras , but it was able to induce a small influx of Erk that could be measured with GFP-Erk2 . Positive_regulation EPHB2 PRKAR2A 14597235 1160466 Moreover , activity is *required* for depolarization induced Rap1 activation and full [Erk] stimulation , but is not involved in that of Ras . Positive_regulation EPHB2 PRKAR2A 14988413 1236712 We conclude that glucagon induced ERK1/2 activation is mediated by and that an increase in [ Ca ( 2+ ) ] ( i ) is *required* for maximal [ERK] activation . Positive_regulation EPHB2 PRKAR2A 15385614 1300143 The [ERK] activation produced by capsaicin is totally *suppressed* by inhibition of either or PKC . Positive_regulation EPHB2 PRKAR2A 16030021 1459488 Knockdown of PDE4D , but not PDE4B , amplifies isoprenaline stimulated phosphorylation of the beta2-adrenergic receptor (beta2-AR) by and *activation* of extracellular signal regulated kinase ( [ERK] ) through G ( i ) . Positive_regulation EPHB2 PRKAR2A 16098594 1507121 Consequently , the inhibitor *down-regulated* [ERK] and p38 MAPK , and decreased cell proliferation . Positive_regulation EPHB2 PRKAR2A 16098594 1507283 However , the treatment of LPS stimulated 38B9 cells with pertussis toxin (PTX) , an inhibitor for the G protein coupled receptor , inhibited the activation of both PKC- and *dependent* [ERK] and significantly reduced LPS induced proliferation but not IgG secretion . Positive_regulation EPHB2 PRKAR2A 16246112 1471504 Beta-arrestin recruited phosphodiesterase-4 desensitizes the *mediated* switching of beta2-adrenoceptor signalling to activation of [ERK] . Positive_regulation EPHB2 PRKAR2A 16452469 1540581 Pharmacological inhibition of cAMP dependent protein kinase (PKA) and siRNA mediated depletion of PKA greatly reduced B-Raf activity , ERK1/2 activation , and cell proliferation in ( WT ) B-Raf cells , whereas it did not affect ( V600E ) B-Raf cells , demonstrating a key *role* of in mediating ( WT ) [B-Raf/ERK] signaling for uveal melanoma cell growth . Positive_regulation EPHB2 PRKAR2A 16452469 1540611 This ruled out a role for Rap1 in the mediated [B-Raf/ERK] *activation* in ( WT ) B-Raf cells . Positive_regulation EPHB2 PRKAR2A 16887887 1632406 Galpha ( s ) dependent [ERK] *activation* was rapid , transient , and blocked by H89 ( a PKA inhibitor ) , but it was insensitive to small interfering RNA mediated depletion of beta-arrestins . Positive_regulation EPHB2 PRKAR2A 19279268 2046351 Upstream , NMDA receptor , adenylyl cyclase ( AC ) and activators *activated* [ERK] in rACC slices . Positive_regulation EPHB2 PRKAR2A 20808799 2314283 We here studied , in the gold-standard non-human primate model of Parkinson 's disease , the changes in *dependent* phosphorylation of DARPP-32 and GluR1 AMPA receptor , as well as in [ERK] and ribosomal protein S6 ( S6 ) phosphorylation , associated to acute and chronic administration of L-DOPA . Positive_regulation EPHB2 PRKAR2A 21518335 2567460 The Phase II ( 5-10 min ) rapid decline in [ERK] phosphorylation *involves* inhibition and serine/threonine phosphatase PP1/PP2A activation . Positive_regulation EPHB2 PRKAR2A 22493291 2601766 Moreover , the NMU induced [p-ERK] increase was *attenuated* by inhibition and activation of PKA by foskolin would mimic the NMU induced I ( A ) increase . Positive_regulation EPHB2 PRKAR2A 22653837 2700852 Cyclic dependent paradoxical *activation* of [Raf/MEK/ERK] signaling in polycystin-2 defective mice treated with sorafenib . Positive_regulation EPHB2 PRKAR2A 9808472 545220 Interestingly , the Ca2+ induced nuclear translocation of [ERK] and Rsk2 to the nucleus *requires* activation . Positive_regulation EPHB2 PRKAR2B 10903877 713262 Activation of by 8-bromo-cyclic AMP or forskolin , and inhibition of PKC by calphostin C , *resulted* in a significant decrease in 3TP activity as well as in vitro [ERK] kinase activity in CRAC . Positive_regulation EPHB2 PRKAR2B 11517300 851417 We conclude that glucagon induced MEK1/2 and ERK1/2 activation is mediated by and that an increase in intracellular calcium concentration is *required* for maximal [ERK] activation . Positive_regulation EPHB2 PRKAR2B 11901221 921917 [ERK] activation through both TPalpha and TPbeta was *dependent* on and phosphoinositide 3-kinase (PI3K) class 1 ( A ) , but not class 1 ( B ) , and was modulated by Harvey-Ras , A-Raf , c-Raf , and Rap1B/B-Raf and also involved transactivation of the epidermal growth factor receptor . Positive_regulation EPHB2 PRKAR2B 12036966 968324 For the beta ( 2 ) AR in HEK-293 cells , where activity is *required* for [ERK] activation , expression of GsCT caused a net inhibition of ERK activation . Positive_regulation EPHB2 PRKAR2B 12473665 1055937 However , PACAP induced GTP loading of Rap1 was not sufficient to account for ERK activation by PACAP because 1 ) PACAP elicited Rap1 GTP loading depended only on phospholipase C , whereas maximal stimulation of [ERK] by PACAP also *required* the activity of , protein kinase C ( PKC ) , and calcium dependent signaling ; Positive_regulation EPHB2 PRKAR2B 12706116 1082497 However , activity was also not *necessary* for the early translocation of [Erk] into the nucleus by NGF or Ras , but it was able to induce a small influx of Erk that could be measured with GFP-Erk2 . Positive_regulation EPHB2 PRKAR2B 14597235 1160467 Moreover , activity is *required* for depolarization induced Rap1 activation and full [Erk] stimulation , but is not involved in that of Ras . Positive_regulation EPHB2 PRKAR2B 14988413 1236713 We conclude that glucagon induced ERK1/2 activation is mediated by and that an increase in [ Ca ( 2+ ) ] ( i ) is *required* for maximal [ERK] activation . Positive_regulation EPHB2 PRKAR2B 15385614 1300144 The [ERK] activation produced by capsaicin is totally *suppressed* by inhibition of either or PKC . Positive_regulation EPHB2 PRKAR2B 16030021 1459489 Knockdown of PDE4D , but not PDE4B , amplifies isoprenaline stimulated phosphorylation of the beta2-adrenergic receptor (beta2-AR) by and *activation* of extracellular signal regulated kinase ( [ERK] ) through G ( i ) . Positive_regulation EPHB2 PRKAR2B 16098594 1507122 Consequently , the inhibitor *down-regulated* [ERK] and p38 MAPK , and decreased cell proliferation . Positive_regulation EPHB2 PRKAR2B 16098594 1507284 However , the treatment of LPS stimulated 38B9 cells with pertussis toxin (PTX) , an inhibitor for the G protein coupled receptor , inhibited the activation of both PKC- and *dependent* [ERK] and significantly reduced LPS induced proliferation but not IgG secretion . Positive_regulation EPHB2 PRKAR2B 16246112 1471505 Beta-arrestin recruited phosphodiesterase-4 desensitizes the *mediated* switching of beta2-adrenoceptor signalling to activation of [ERK] . Positive_regulation EPHB2 PRKAR2B 16452469 1540582 Pharmacological inhibition of cAMP dependent protein kinase (PKA) and siRNA mediated depletion of PKA greatly reduced B-Raf activity , ERK1/2 activation , and cell proliferation in ( WT ) B-Raf cells , whereas it did not affect ( V600E ) B-Raf cells , demonstrating a key *role* of in mediating ( WT ) [B-Raf/ERK] signaling for uveal melanoma cell growth . Positive_regulation EPHB2 PRKAR2B 16452469 1540612 This ruled out a role for Rap1 in the *mediated* [B-Raf/ERK] activation in ( WT ) B-Raf cells . Positive_regulation EPHB2 PRKAR2B 16887887 1632407 Galpha ( s ) *dependent* [ERK] activation was rapid , transient , and blocked by H89 ( a PKA inhibitor ) , but it was insensitive to small interfering RNA mediated depletion of beta-arrestins . Positive_regulation EPHB2 PRKAR2B 19279268 2046352 Upstream , NMDA receptor , adenylyl cyclase ( AC ) and activators *activated* [ERK] in rACC slices . Positive_regulation EPHB2 PRKAR2B 20808799 2314284 We here studied , in the gold-standard non-human primate model of Parkinson 's disease , the changes in *dependent* phosphorylation of DARPP-32 and GluR1 AMPA receptor , as well as in [ERK] and ribosomal protein S6 ( S6 ) phosphorylation , associated to acute and chronic administration of L-DOPA . Positive_regulation EPHB2 PRKAR2B 21518335 2567461 The Phase II ( 5-10 min ) rapid decline in [ERK] phosphorylation *involves* inhibition and serine/threonine phosphatase PP1/PP2A activation . Positive_regulation EPHB2 PRKAR2B 22493291 2601767 Moreover , the NMU induced [p-ERK] increase was *attenuated* by inhibition and activation of PKA by foskolin would mimic the NMU induced I ( A ) increase . Positive_regulation EPHB2 PRKAR2B 22653837 2700853 Cyclic *dependent* paradoxical activation of [Raf/MEK/ERK] signaling in polycystin-2 defective mice treated with sorafenib . Positive_regulation EPHB2 PRKAR2B 9808472 545221 Interestingly , the Ca2+ induced nuclear translocation of [ERK] and Rsk2 to the nucleus *requires* activation . Positive_regulation EPHB2 PRKCA 11093170 754960 Moreover , deficiency in fyn dependent PLC-gamma1 catalytic activity may contribute to reduced *dependent* [ERK] activation . Positive_regulation EPHB2 PRKCA 12472895 1023114 Specific inhibition of with safingol *blocked* the phosphorylation of [ERK] induced by TPA . Positive_regulation EPHB2 PRKCA 15917995 1413219 Activation of is *required* for TPA triggered [ERK] ( MAPK ) signaling and growth inhibition of human hepatoma cell HepG2 . Positive_regulation EPHB2 PRKCA 15917995 1413229 Taken together , we concluded that is specifically *required* for TPA induced [ERK] ( MAPK ) signaling to trigger gene expressions of p15(INK4b) and p16(INK4a) leading to HepG2 growth inhibition . Positive_regulation EPHB2 PRKCA 16608852 1568842 Membrane accumulation of influenza A virus hemagglutinin triggers nuclear export of the viral genome via *mediated* activation of [ERK] signaling . Positive_regulation EPHB2 PRKCA 19423709 2096146 Activation of by EPAC1 is *required* for the [ERK-] and CCAAT/enhancer binding protein beta dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells . Positive_regulation EPHB2 PRKCB 18167130 1869650 The phosphorylation of [ERK] ( 1/2 ) and p38 MAPK was *regulated* by upregulated in HCC cells through the integrated use of PKC beta RNA interference , the PKC beta specific inhibitor enzastaurin and a PKC activator phorbol-12-myristate-13-acetate . Positive_regulation EPHB2 PRL 11994384 938915 *induces* [ERK] phosphorylation in epithelial and CD56 ( + ) natural killer cells of the human endometrium . Positive_regulation EPHB2 PRL 11994384 938919 Using immunofluorescence histochemistry , *induced* phosphorylation of [ERK] in the stromal compartment was localized to the uterine-specific CD56 ( + ) natural killer ( NK ) cells . Positive_regulation EPHB2 PRL 16785991 1654031 Our data suggest that PRL synergistically augments EGF signaling in T47D breast cancer cells at least in part by lessening EGF induced EGFR downregulation and that this effect requires *induced* [ERK] activity and threonine phosphorylation of EGFR . Positive_regulation EPHB2 PRL 16840547 1613063 Because S179D and basic fibroblast growth factor (bFGF) have both been shown to *activate* [ERK] , the effect of S179D PRL on bFGF induced ERK signaling was examined . Positive_regulation EPHB2 PRL 17255201 1725212 *induced* phosphorylation of JAK2 and [ERK] , whereas IFN-gamma induced phosphorylation of JAK1 , JAK2 , and p38 MAPK . Positive_regulation EPHB2 PRL 19022892 2047289 also *induced* [ERK] phosphorylation in vitro in the hypothalamic cell line , 4B , which expresses PRL receptors , and in primary hypothalamic neuronal cultures . Positive_regulation EPHB2 PRL 19350575 2057644 *induced* [ERK] and JNK phosphorylation . Positive_regulation EPHB2 PRL 20865346 2375632 , by binding to its GPCR receptors , of which there are short and long forms , also *activates* [ERK] , and this is necessary for the control of the expression of corticotrophin releasing hormone-an important regulator of the HPA axis . Positive_regulation EPHB2 PRLH 10652364 663005 Both pertussis toxin , which inactivates G ( i ) /G ( o ) proteins , and exogenous expression of a peptide derived from the carboxyl terminus of the beta-adrenergic receptor kinase I , which specifically blocks signaling mediated by the betagamma subunits of G proteins , completely blocked the *induced* [ERK] activation , suggesting the involvement of G ( i ) /G ( o ) proteins in the PrRP induced ERK activation . Positive_regulation EPHB2 PRLH 10652364 663006 Down-regulation of cellular protein kinase C did not significantly inhibit the *induced* [ERK] activation , suggesting that a protein kinase C-independent pathway is mainly involved . Positive_regulation EPHB2 PRLH 10652364 663007 *induced* [ERK] activation was not dependent on either extracellular Ca ( 2+ ) or intracellular Ca ( 2+ ) . Positive_regulation EPHB2 PRLH 10652364 663008 These results suggest that differentially *activates* [ERK] and JNK , and both cascades are necessary to elicit rPRL promoter activity in an Ets dependent mechanism . Positive_regulation EPHB2 PRLH 11751586 898359 Both pertussis toxin ( 10 ng/ml ) , which inactivates Gi/Go proteins , and expression of a peptide derived from the carboxyl terminus of the beta-adrenergic receptor kinase I , which specifically blocks signaling mediated by the betagamma subunits of G proteins , completely blocked the PrRP induced Akt activation , suggesting that Gi/Go proteins are involved in PrRP induced Akt activation , as they are in the *activation* of [ERK] by . Positive_regulation EPHB2 PROK1 17402705 1735778 also significantly *increased* [ERK] phosphorylation , while both the free doxorubicin and HYD conjugate slightly decreased it . Positive_regulation EPHB2 PROM1 20800650 2324490 We found that overexpression significantly *activated* [Erk] , which suggested CD133 involved in activation of MAPK/Erk pathway . Positive_regulation EPHB2 PROM1 24188385 2890261 Co-culture with CM resulted in an increased resistance to Adriamycin and enhanced expressions of a-FP , MMP9 , ABCG2 , , and SOX2 , as well as the *activation* of [ERK] , AKT , WNT , and TGF-ß1 pathways . Positive_regulation EPHB2 PROX1 23391722 2748220 Expression of mutant RAF1 ( S259A ) in ECs activated [ERK] and *induced* SOX18 and expression , leading to increased commitment of venous ECs to the lymphatic fate . Positive_regulation EPHB2 PRR11 20075844 2241632 Aliskiren is the most potent inhibitor of intracellular AngII levels of human podocytes among RAS inhibitors , although it is incapable of inhibiting the ( *dependent* [ERK] phosphorylation . Positive_regulation EPHB2 PRR12 20075844 2241638 Aliskiren is the most potent inhibitor of intracellular AngII levels of human podocytes among RAS inhibitors , although it is incapable of inhibiting the ( *dependent* [ERK] phosphorylation . Positive_regulation EPHB2 PRR13 20075844 2241631 Aliskiren is the most potent inhibitor of intracellular AngII levels of human podocytes among RAS inhibitors , although it is incapable of inhibiting the ( *dependent* [ERK] phosphorylation . Positive_regulation EPHB2 PRR14 20075844 2241636 Aliskiren is the most potent inhibitor of intracellular AngII levels of human podocytes among RAS inhibitors , although it is incapable of inhibiting the ( *dependent* [ERK] phosphorylation . Positive_regulation EPHB2 PRR15 20075844 2241630 Aliskiren is the most potent inhibitor of intracellular AngII levels of human podocytes among RAS inhibitors , although it is incapable of inhibiting the ( *dependent* [ERK] phosphorylation . Positive_regulation EPHB2 PRR16 20075844 2241639 Aliskiren is the most potent inhibitor of intracellular AngII levels of human podocytes among RAS inhibitors , although it is incapable of inhibiting the ( *dependent* [ERK] phosphorylation . Positive_regulation EPHB2 PRR18 20075844 2241637 Aliskiren is the most potent inhibitor of intracellular AngII levels of human podocytes among RAS inhibitors , although it is incapable of inhibiting the ( *dependent* [ERK] phosphorylation . Positive_regulation EPHB2 PRR19 20075844 2241643 Aliskiren is the most potent inhibitor of intracellular AngII levels of human podocytes among RAS inhibitors , although it is incapable of inhibiting the ( *dependent* [ERK] phosphorylation . Positive_regulation EPHB2 PRR21 20075844 2241644 Aliskiren is the most potent inhibitor of intracellular AngII levels of human podocytes among RAS inhibitors , although it is incapable of inhibiting the ( *dependent* [ERK] phosphorylation . Positive_regulation EPHB2 PRR22 20075844 2241635 Aliskiren is the most potent inhibitor of intracellular AngII levels of human podocytes among RAS inhibitors , although it is incapable of inhibiting the ( *dependent* [ERK] phosphorylation . Positive_regulation EPHB2 PRR24 20075844 2241633 Aliskiren is the most potent inhibitor of intracellular AngII levels of human podocytes among RAS inhibitors , although it is incapable of inhibiting the ( *dependent* [ERK] phosphorylation . Positive_regulation EPHB2 PRR25 20075844 2241645 Aliskiren is the most potent inhibitor of intracellular AngII levels of human podocytes among RAS inhibitors , although it is incapable of inhibiting the ( *dependent* [ERK] phosphorylation . Positive_regulation EPHB2 PRR26 20075844 2241640 Aliskiren is the most potent inhibitor of intracellular AngII levels of human podocytes among RAS inhibitors , although it is incapable of inhibiting the ( *dependent* [ERK] phosphorylation . Positive_regulation EPHB2 PRR3 20075844 2241629 Aliskiren is the most potent inhibitor of intracellular AngII levels of human podocytes among RAS inhibitors , although it is incapable of inhibiting the ( *dependent* [ERK] phosphorylation . Positive_regulation EPHB2 PRR4 20075844 2241628 Aliskiren is the most potent inhibitor of intracellular AngII levels of human podocytes among RAS inhibitors , although it is incapable of inhibiting the ( *dependent* [ERK] phosphorylation . Positive_regulation EPHB2 PRR5 20075844 2241641 Aliskiren is the most potent inhibitor of intracellular AngII levels of human podocytes among RAS inhibitors , although it is incapable of inhibiting the ( *dependent* [ERK] phosphorylation . Positive_regulation EPHB2 PRR7 20075844 2241634 Aliskiren is the most potent inhibitor of intracellular AngII levels of human podocytes among RAS inhibitors , although it is incapable of inhibiting the ( *dependent* [ERK] phosphorylation . Positive_regulation EPHB2 PRR9 20075844 2241642 Aliskiren is the most potent inhibitor of intracellular AngII levels of human podocytes among RAS inhibitors , although it is incapable of inhibiting the ( *dependent* [ERK] phosphorylation . Positive_regulation EPHB2 PSAP 10383054 624408 Recently , we demonstrated that and prosaptides ( peptides encompassing the neurotrophic sequence in prosaposin ) prevent cell death and *increase* [extracellular regulated kinase (ERK)] phosphorylation and sulfatide content in primary Schwann cells or oligodendrocytes ( Hiraiwa et al. , 1997a ) . Positive_regulation EPHB2 PSAP 11156962 780680 this effect was inhibited by the MEK inhibitor PD98059 , indicating that *induced* [ERK] phosphorylation is required for stimulation of DNA synthesis . Positive_regulation EPHB2 PSAP 15242760 1270697 *led* to rapid [ERK] phosphorylation in U937 cells as detected by anti-phospho-p44/42 mitogen activated protein (MAP) kinase and anti-phosphotyrosine reactivity on ERK immunoprecipitates . Positive_regulation EPHB2 PSEN1 18367332 1892590 *regulates* [extracellular regulated kinase (Erk)] activity by a protein kinase C alpha dependent mechanism . Positive_regulation EPHB2 PSEN2 18367332 1892591 *regulates* [extracellular regulated kinase (Erk)] activity by a protein kinase C alpha dependent mechanism . Positive_regulation EPHB2 PSMB9 23698301 2806061 These findings suggest that *mediated* [ERK] activation is involved in the generation of EBV associated epithelial malignancies . Positive_regulation EPHB2 PSMG1 17226785 1696258 The VSMC line *activates* the MAP kinase [Erk] in response to the cholesterol sequestering agents methyl-beta-cyclodextrin and nystatin . Positive_regulation EPHB2 PSTPIP2 24407241 2900620 These observations suggest that recruiting PEST phosphatases somehow blocked CSK activity and *led* to enhanced activation of Src family kinases and reduced [ERK] phosphorylation , which ultimately repressed megakaryocyte differentiation . Positive_regulation EPHB2 PTAFR 11861812 917374 Using a model system created by retroviral mediated transduction of the PAF-R into the PAF-R negative epidermal cell line KB , we now demonstrate that the activation of the epidermal *results* in the activation of both the extracellular signal regulated kinase ( [ERK] ) and p38 , but not the jun N-terminal kinase mitogen activated protein (MAP) kinase pathways . Positive_regulation EPHB2 PTBP1 20967853 2369596 Selective [ERK] activation *induced* mouse and human to secrete bioactive transforming growth factor ß , a process required for suppression of T cell responses and differentiation of antigen-specific Treg cells . Positive_regulation EPHB2 PTBP2 20967853 2369593 Selective [ERK] activation *induced* mouse and human to secrete bioactive transforming growth factor ß , a process required for suppression of T cell responses and differentiation of antigen-specific Treg cells . Positive_regulation EPHB2 PTCH1 18004977 1835816 Only one line had thyroid targeted , doxycycline regulated RET/PTC1 and luciferase coexpression , in which doxycycline induction of *led* to [Erk] phosphorylation and reduced expression of the sodium/iodide symporter ( NIS ) . Positive_regulation EPHB2 PTEN 12479095 1023943 The objective of this paper was to study extracellular signal regulated kinase ( ERK ) activation in endometrial carcinoma cell line Ishikawa under the stimulation of IGF-1 , and to elucidate the *role* of suppressor encoprotein in activation of [ERK] . Positive_regulation EPHB2 PTEN 18726116 2011903 Stable expression in PTEN-null UM-UC-3 cells *increased* serum induced [ERK] activation and sensitivity to PD98059-treatment , and reduced sensitivity to LY294002 after 6 weeks of exposure . Positive_regulation EPHB2 PTGER4 12566441 1071740 Furthermore , this *activation* of [PI3K/ERK] signaling by the receptors induces the functional expression of early growth response factor-1 (EGR-1) . Positive_regulation EPHB2 PTGS2 11292836 819913 Bombesin stimulation of expression *requires* an increase in [ Ca ( 2+ ) ] ( i ) , activation of extracellular signal regulated kinase ( [ERK] ) -1 and -2 and p38 ( MAPK ) , and increased activation and expression of the transcription factors Elk-1 , ATF-2 , c-Fos , and c-Jun . Positive_regulation EPHB2 PTGS2 12891702 1117753 Also , gastrin dependent expression did not *require* PKC activity , activation of [ERK] , or transactivation of EGFR . Positive_regulation EPHB2 PTGS2 15304095 1284512 These results suggest that IGF-II *induces* expression through the tyrosine [kinase-Src-ERK] and tyrosine kinase-PI3-kinase pathways , but not via p38 MAPK pathway , and that the basal JNK activity is required for the upregulation of COX-2 by IGF-II , as well . Positive_regulation EPHB2 PTGS2 17574271 1792284 In vitro , Ro26-2198 inhibited IL-1beta induced [ERK] activation and *induction* and decreased HCA-7 cell proliferation . Positive_regulation EPHB2 PTGS2 17592548 1764677 We previously reported that the epidermal growth factor receptor (EGFR) is overexpressed in papilloma cells , that cyclooxygenase-2 (COX-2) is induced , and that expression in primary papilloma cells *requires* activation of the EGFR but not [Erk] . Positive_regulation EPHB2 PTGS2 19584262 2111698 *stimulates* [ERK] phosphorylation via PGE2 . Positive_regulation EPHB2 PTGS2 19584262 2111699 This *induced* [ERK] activation seems to increase ATR expression and activity in endogenous COX-2 overexpressing cancer cells as well as in COX-2 overexpressing stable cell lines . Positive_regulation EPHB2 PTH 10665929 665308 The physiologic role of *stimulated* [ERK] is unknown . Positive_regulation EPHB2 PTH 10665929 665309 The purpose of the present study was to identify signaling components involved in *stimulated* [ERK] activity and to determine the role of PTH stimulated ERK activity in regulation of phosphate transport . Positive_regulation EPHB2 PTH 10665929 665310 *stimulated* [ERK] activity was measured in opossum kidney ( OK ) cell lysates as phosphorylation of myelin basic protein by an in vitro kinase assay . Positive_regulation EPHB2 PTH 10665929 665311 *stimulated* a dose dependent increase in [ERK] activity with a peak at 10 ( -7 ) M . Positive_regulation EPHB2 PTH 10665929 665312 The time course was biphasic with an early peak at 10 min and a later peak at 20 min. Pretreatment of OK cells with the nonreceptor tyrosine kinase inhibitors genistein and herbimycin A or with the phosphatidylinositol 3-kinase (PI-3K) inhibitors wortmannin and LY294002 blocked the early and late peaks of *stimulated* [ERK] activity . Positive_regulation EPHB2 PTH 10665929 665313 Pretreatment with the protein kinase C inhibitor calphostin C blocked only the later phase of *stimulated* [ERK] . Positive_regulation EPHB2 PTH 10665929 665314 It is concluded that *stimulates* [ERK] through two signal transduction pathways : an early pathway dependent on tyrosine kinase and PI-3K and a late pathway dependent on protein kinase C. PTH stimulated ERK regulates phosphate transport by a mechanism other than downregulation of NaPi-4 expression . Positive_regulation EPHB2 PTH 16029167 1473509 ( 1-34 ) *caused* phosphorylation of [ERK] ( extracellular-signal regulated kinase ) 1/2 in PTHR expressed cells mainly mediated through EGF ( epidermal growth factor) receptor . Positive_regulation EPHB2 PTH 16492667 1548716 The time course of ERK1/2 activation was biphasic with an early peak at 10 min and a later sustained ERK1/2 activation persisting for greater than 60 min. Pretreatment of HEK293 cells with the PKA inhibitor H89 or the PKC inhibitor GF109203X , individually or in combination reduced the early component of *stimulated* [ERK] activity . Positive_regulation EPHB2 PTH 17107942 1700422 *stimulated* [ERK] by wild-type , mutated and truncated PTH1Rs 21- , 27- and 57-fold , respectively . Positive_regulation EPHB2 PTH 17525124 1767229 We conclude that *stimulated* [ERK] activation in DCT cells proceeds with a rapid but transient phase that may involve betaAr1 . Positive_regulation EPHB2 PTH 18550646 1940618 mediated regulation of Na+-K+-ATPase *requires* Src kinase dependent [ERK] phosphorylation . Positive_regulation EPHB2 PTH 18550646 1940626 In the present work utilizing opossum kidney cells , a model of renal proximal tubule , *stimulated* [ERK] phosphorylation and membrane translocation of PKCalpha were prevented by inhibition of Src kinase , PLC , and calcium entry . Positive_regulation EPHB2 PTH 18550646 1940629 Pharmacological inhibition of PLA2 did not prevent *stimulated* [ERK] phosphorylation but completely prevented PKCalpha translocation . Positive_regulation EPHB2 PTH1R 17107942 1700426 We conclude that [ERK] phosphorylation in distal kidney cells by PTH *requires* activation of G ( i ) , which leads to stimulation of metalloprotease mediated cleavage of HB-EGF and transactivation of the EGFR and is regulated by EBP50 . Positive_regulation EPHB2 PTH1R 20578167 2367894 Signaling and *activation* of cAMP and [ERK] by was decreased significantly compared with PTHR . Positive_regulation EPHB2 PTHLH 19633068 2137923 Ectopic expression of *stimulated* [ERK] phosphorylation . Positive_regulation EPHB2 PTHLH 19633068 2137925 In MV522 cells , *had* similar effects on DNA synthesis , cyclin A2 expression , pRb levels , CDK2-cyclin A2 association , and [ERK] activation . Positive_regulation EPHB2 PTK2 11425486 831335 These results demonstrated that GO and MGO triggered two distinct signal cascades , one for *dependent* control of [ERK] and another for PTK independent redox linked activation of JNK/p38 MAPK and caspases in HUVECs , depending on the structure of the carbon skeleton of the chemicals . Positive_regulation EPHB2 PTK2 12774925 1095279 We found that Lyn was constitutively phosphorylated on tyrosine , and that [ERK] and p38 MAPK were constitutively *active* in all cases of the B-cell tumor . Positive_regulation EPHB2 PTK2 15797477 1390345 Moreover , the ConA induced IFN-gamma mRNA expression was partly prevented by genistein , a global inhibitor , and PD-98059 , an [ERK] *inhibitor* , respectively . Positive_regulation EPHB2 PTK2 17210798 1709557 Taken together , these findings indicate that [ERK] *activation* through regulates antidepressant induced GDNF production and that the GDNF production in glial cells may be a novel action of the antidepressant , which is independent of monoamine . Positive_regulation EPHB2 PTK2 17583725 1768068 In the presence of ATB , overexpression significantly *increased* basal phosphorylation of [ERK] ( 40.2+/-8.6 % P < 0.05 ) , p38 ( 39.5+/-11.7 % , P < 0.05 ) , JNK ( 86+/-29.4 % , P < 0.05 ) and stretch induced p38 ( 48.1+/-8.7 % , P < 0.05 ) and JNK ( 85.0+/-19.4 % , P < 0.05 ) phosphorylation . Positive_regulation EPHB2 PTK2 17583725 1768069 However , in the absence of ATB , overexpression significantly reduced basal and stretch *induced* phosphorylation of only [ERK] . Positive_regulation EPHB2 PTK2 19720055 2145287 On the other hand , the inhibitors *caused* disparate effects on [ERK] phosphorylation , and co-treatment with the MEK/ERK inhibitor PD98059 enhanced the pro-apoptotic capacity of the PTK inhibitors . Positive_regulation EPHB2 PTK2 22366087 2566017 We also demonstrated that inhibits endothelial cell migration and shear *stimulated* [ERK] activation . Positive_regulation EPHB2 PTK2 9864370 556211 Consistent with this , we also observed inhibition of BrdU incorporation and [Erk] *activation* by FAK Y397F mutant and , but not FRNKDeltaC14 , in transient transfection assays using primary human foreskin fibroblasts . Positive_regulation EPHB2 PTK6 11425486 831336 These results demonstrated that GO and MGO triggered two distinct signal cascades , one for *dependent* control of [ERK] and another for PTK independent redox linked activation of JNK/p38 MAPK and caspases in HUVECs , depending on the structure of the carbon skeleton of the chemicals . Positive_regulation EPHB2 PTK6 12774925 1095280 We found that Lyn was constitutively phosphorylated on tyrosine , and that [ERK] and p38 MAPK were constitutively *active* in all cases of the B-cell tumor . Positive_regulation EPHB2 PTK6 15797477 1390346 Moreover , the ConA induced IFN-gamma mRNA expression was partly prevented by genistein , a global inhibitor , and PD-98059 , an [ERK] *inhibitor* , respectively . Positive_regulation EPHB2 PTK6 17210798 1709558 Taken together , these findings indicate that [ERK] *activation* through regulates antidepressant induced GDNF production and that the GDNF production in glial cells may be a novel action of the antidepressant , which is independent of monoamine . Positive_regulation EPHB2 PTK6 19720055 2145288 On the other hand , the inhibitors *caused* disparate effects on [ERK] phosphorylation , and co-treatment with the MEK/ERK inhibitor PD98059 enhanced the pro-apoptotic capacity of the PTK inhibitors . Positive_regulation EPHB2 PTK7 11425486 831337 These results demonstrated that GO and MGO triggered two distinct signal cascades , one for *dependent* control of [ERK] and another for PTK independent redox linked activation of JNK/p38 MAPK and caspases in HUVECs , depending on the structure of the carbon skeleton of the chemicals . Positive_regulation EPHB2 PTK7 12774925 1095281 We found that Lyn was constitutively phosphorylated on tyrosine , and that [ERK] and p38 MAPK were constitutively *active* in all cases of the B-cell tumor . Positive_regulation EPHB2 PTK7 15797477 1390347 Moreover , the ConA induced IFN-gamma mRNA expression was partly prevented by genistein , a global inhibitor , and PD-98059 , an [ERK] *inhibitor* , respectively . Positive_regulation EPHB2 PTK7 17210798 1709559 Taken together , these findings indicate that [ERK] *activation* through regulates antidepressant induced GDNF production and that the GDNF production in glial cells may be a novel action of the antidepressant , which is independent of monoamine . Positive_regulation EPHB2 PTK7 19720055 2145289 On the other hand , the inhibitors *caused* disparate effects on [ERK] phosphorylation , and co-treatment with the MEK/ERK inhibitor PD98059 enhanced the pro-apoptotic capacity of the PTK inhibitors . Positive_regulation EPHB2 PTN 24727451 2935797 EGFR trans-activation mediates *induced* activation of Akt and [Erk] in cultured osteoblasts . Positive_regulation EPHB2 PTN 24727451 2935808 Together , these results suggest that induced [Akt/Erk] *activation* and some of its pleiotropic functions are mediated by EGFR trans-activation in cultured osteoblasts . Positive_regulation EPHB2 PTPN11 10409724 630431 Overexpression of truncated that lacks Grb2 interacting sites , but not the full-length catalytically inactive SHP-2 , *reduces* [ERK] activation by IL-6 , confirming the signal mediating role of SHP-2 . Positive_regulation EPHB2 PTPN11 10669730 665969 To address the molecular mechanism for the positive *role* of in mediating [Erk] induction , we evaluated the activation of signaling components upstream of Erk in Shp-2 mutant cells . Positive_regulation EPHB2 PTPN11 11046147 743138 To elucidate the Gab1 dependent signals required for epithelial morphogenesis , we undertook a structure-function approach and demonstrate that association of Gab1 with the tyrosine phosphatase is *required* for sustained [Erk] activation and for epithelial morphogenesis downstream from the Met receptor . Positive_regulation EPHB2 PTPN11 11085989 810051 Divergent *roles* of in [ERK] activation by leptin receptors . Positive_regulation EPHB2 PTPN11 11085989 810059 The phosphatase activity of SHP-2 is required for both pathways , whereas activation of [ERK] via Tyr-985 of ObRb also *requires* tyrosine phosphorylation of . Positive_regulation EPHB2 PTPN11 11323411 827216 To investigate the mechanism by which Gab1 and *mediate* [ERK] activation , we characterized the Gab1-SHP2 interaction . Positive_regulation EPHB2 PTPN11 11323411 827228 Thus , physical association of activated with Gab1 is necessary and *sufficient* to mediate the [ERK] mitogen activated protein kinase activation . Positive_regulation EPHB2 PTPN11 11896055 944428 SHP2 is shown to associate with and dephosphorylate Gab1 , suggesting that EGF stimulated [ERK] might *act* through the regulation of . Positive_regulation EPHB2 PTPN11 12721296 1106500 The protein tyrosine phosphatase *regulates* interleukin-1 induced [ERK] activation in fibroblasts . Positive_regulation EPHB2 PTPN11 12923167 1151213 Tyrosyl phosphorylation of is *required* for normal [ERK] activation in response to some , but not all , growth factors . Positive_regulation EPHB2 PTPN11 12935294 1157809 However , expression of WT *increased* [ERK] ( extracellular-signal regulated kinase ) activation . Positive_regulation EPHB2 PTPN11 14687660 1190218 Importantly , SHP-2 expression also abrogated angiotensin II-induced activation of ERK , whereas expression of catalytically inactive *caused* sustained [ERK] activation . Positive_regulation EPHB2 PTPN11 14963045 1235698 These results indicate that is *involved* in the Ras independent modification of [Erk] signals that is necessary for the morphogenetic activity of CagA . Positive_regulation EPHB2 PTPN11 14967142 1209092 *regulates* SRC family kinase activity and [Ras/Erk] activation by controlling Csk recruitment . Positive_regulation EPHB2 PTPN11 15170389 1280327 Expression of the Gab2 Tyr-614 -- > Phe ( Y614F ) mutant , defective in SHP-2 association , prevents ERK ( extracellular-signal regulated kinase ) activation and expression of a luciferase reporter plasmid driven by the c-fos SRE ( serum response element ) , indicating that interaction of with Gab2 is *required* for [ERK] activation in response to IL-2 . Positive_regulation EPHB2 PTPN11 15798102 1390462 Higashi et al. now demonstrate that CagA dependent activation *leads* to sustained activation of [ERK] ( extracellular signal regulated kinase ) , culminating in morphological changes that mimic unrestrained stimulation by growth factors . Positive_regulation EPHB2 PTPN11 16181551 1462006 positively *regulates* [ERK] activation and prostate cancer invasion , whereas MKP5 inhibits the invasion by suppressing p38 activation . Positive_regulation EPHB2 PTPN11 16705167 1560776 Tcptp-/- macrophages also have increased tyrosine phosphorylation and recruitment of a complex to the CSF-1R and enhanced *activation* of [Erk] after CSF-1 stimulation , which are important molecular events in CSF-1 induced differentiation . Positive_regulation EPHB2 PTPN11 17143285 1678685 is *required* for [RAS-ERK] MAP kinase (MAPK) cascade activation , and Noonan syndrome mutants enhance ERK activation ex vivo and in mice . Positive_regulation EPHB2 PTPN11 18421299 1907836 Inhibition of *suppressed* EGF induced activation of the [Ras-ERK] and the phosphatidylinositol 3 kinase-Akt signaling pathways , abolished anchorage independent growth , induced epithelial cell morphology and led to reversion to a normal breast epithelial phenotype . Positive_regulation EPHB2 PTPN11 18452557 1915911 FRS2alpha acts as ` a conning center ' in FGF signaling mainly because it induces sustained levels of *activation* of [ERK] via binding sites and Grb2 binding sites , though the contribution of the former is greater . Positive_regulation EPHB2 PTPN11 18827006 1970782 Significantly , we demonstrate that phosphorylation of on Y279 downregulates growth factor *induced* sustained [ERK] activation and proliferation , supporting a role for Abl kinases not only in potentiating growth factor mediated SHP-2 signaling , but also in negative-feedback regulation . Positive_regulation EPHB2 PTPN11 19587381 2129549 inhibition *reduced* [ERK] activation in G-CSF , but not M-CSF , and reduced colony forming unit-granulocytes , underscoring divergent pathways to ERK activation . Positive_regulation EPHB2 PTPN11 19786542 2147691 was dispensable for Fc ( epsilon ) RI-induced degranulation of BMMCs , but was *required* for maximal activation of [Erk] and Jnk mitogen activated protein kinases . Positive_regulation EPHB2 PTPN11 20472558 2283338 Interactions between SHP-2 and PTPalpha , recruitment of to focal adhesions , IL-1 induced [ERK] *activation* , and MMP3 expression were all blocked by point mutations in the phosphatase domains of PTPalpha . Positive_regulation EPHB2 PTPN11 23318428 2860715 It has been controversial how *induces* [Erk] activation . Positive_regulation EPHB2 PTPN11 23318428 2860717 We here demonstrate that EphA2 is responsible for mediated [Erk] *activation* by phosphorylating Tyr542 and Tyr580 of Shp2 in the cells stimulated with growth factors . Positive_regulation EPHB2 PTPN11 23318428 2860725 Expression of with Tyr542/580Phe mutations *resulted* in the suppression of [Erk] activation . Positive_regulation EPHB2 PTPN11 23318428 2860728 Phosphatase-active and -inactive , and wild-type Shp2s bound equally to Grb2 , suggesting that phosphorylation of Tyr542/580 of Shp2 was essential but not sufficient for mediated [Erk] *activation* . Positive_regulation EPHB2 PTPN11 23318428 2860730 We found that Gab1 ( Grb2 associated binder 1 ) was involved in the mutant mediated [Erk] *activation* . Positive_regulation EPHB2 PTPN11 23318428 2860732 Collectively , tyrosine phosphorylation of Shp2 by EphA2 contributes to the phosphatase independent *mediated* activation of [Erk] and might be involved in Shp2 associated diseases . Positive_regulation EPHB2 PTPN11 24003223 2851343 Furthermore , GAREM2 and *regulate* [Erk] activity in EGF stimulated cells . Positive_regulation EPHB2 PTPN11 24035415 2846240 is *required* for full activation of [RAS-Erk] signaling in the cytoplasm and is also present in the nucleus , where it promotes Wnt target gene activation through dephosphorylation of parafibromin . Positive_regulation EPHB2 PTPN11 24284065 2904564 Genetic interaction experiments further demonstrate that direct binding of to Frs2a is *necessary* for activation of [ERK] signaling , whereas constitutive activation of either Shp2 or Kras signaling can compensate for the absence of Frs2a in lens development . Positive_regulation EPHB2 PTPN11 24431450 2901354 *dependent* [ERK] signaling is essential for induction of Bergmann glia and foliation of the cerebellum . Positive_regulation EPHB2 PTPN11 9632795 513080 These observations suggest that Gab1 acts as an adapter molecule in transmitting signals to ERK MAP kinase for the cytokine receptor gp130 and that , PI-3 kinase , and Ras are *involved* in Gab1 mediated [ERK] activation . Positive_regulation EPHB2 PTPN11 9892010 586561 We show that the activation of [ERK] via SSTR1 is pertussis toxin sensitive and *requires* the small G protein Ras , phosphatidylinositol 3-kinase , the serine/threonine kinase Raf-1 , and the protein tyrosine phosphatase . Positive_regulation EPHB2 PTPN21 20923765 2353498 Silencing of promotes degradation of EGF receptor and *inhibits* downstream [ERK] signaling . Positive_regulation EPHB2 PTPN5 12483215 1032908 We have investigated the *role* of , a striatal enriched tyrosine phosphatase , in the regulation of [ERK] activity in rat neurons . Positive_regulation EPHB2 PTPN5 18708052 2008845 Here , we investigate the *role* of in D2R mediated [ERK] signaling , especially in dopaminergic neuronal development . Positive_regulation EPHB2 PTPRC 15661907 1365116 signals outside of lipid rafts to *promote* [ERK] activation , synaptic raft clustering , and IL-2 production . Positive_regulation EPHB2 PTX3 11287337 800042 *caused* a rapid time dependent increase in bovine pulmonary artery endothelial cell [ERK] activity that was significantly attenuated by 1 ) pharmacological inhibition of MEK , the upstream ERK activating kinase , 2 ) an MEK dominant negative construct , and 3 ) PKC inhibition with bisindolylmaleimide . Positive_regulation EPHB2 PTX3 11287337 800044 There was little evidence for the involvement of either Gbetagamma-subunits , Ras GTPases , Raf-1 , p60 ( src ) , or phosphatidylinositol 3'-kinases in mediated [ERK] *activation* . Positive_regulation EPHB2 PTX3 11287337 800049 Both the purified beta-oligomer binding subunit of the PTX holotoxin and a PTX holotoxin mutant genetically engineered to eliminate intrinsic ADP ribosyltransferase activity completely reproduced PTX effects on ERK activation , suggesting that induced [ERK] *activation* involves a novel PKC dependent signaling mechanism that is independent of either Ras or Raf-1 activities and does not require G protein ADP ribosylation . Positive_regulation EPHB2 PTX3 19457093 2101677 This was based on the attenuation of the micro-opioid *activation* of [ERK] by , the CaM antagonist , W-7 , and siRNA silencing of beta-arrestin2 . Positive_regulation EPHB2 PTX3 22005063 2498503 Moreover , treatment *induced* [Erk½] phosphorylation in both cell lines . Positive_regulation EPHB2 PTX4 11287337 800041 *caused* a rapid time dependent increase in bovine pulmonary artery endothelial cell [ERK] activity that was significantly attenuated by 1 ) pharmacological inhibition of MEK , the upstream ERK activating kinase , 2 ) an MEK dominant negative construct , and 3 ) PKC inhibition with bisindolylmaleimide . Positive_regulation EPHB2 PTX4 11287337 800043 There was little evidence for the involvement of either Gbetagamma-subunits , Ras GTPases , Raf-1 , p60 ( src ) , or phosphatidylinositol 3'-kinases in mediated [ERK] *activation* . Positive_regulation EPHB2 PTX4 11287337 800048 Both the purified beta-oligomer binding subunit of the PTX holotoxin and a PTX holotoxin mutant genetically engineered to eliminate intrinsic ADP ribosyltransferase activity completely reproduced PTX effects on ERK activation , suggesting that *induced* [ERK] activation involves a novel PKC dependent signaling mechanism that is independent of either Ras or Raf-1 activities and does not require G protein ADP ribosylation . Positive_regulation EPHB2 PTX4 19457093 2101676 This was based on the attenuation of the micro-opioid *activation* of [ERK] by , the CaM antagonist , W-7 , and siRNA silencing of beta-arrestin2 . Positive_regulation EPHB2 PTX4 22005063 2498502 Moreover , treatment *induced* [Erk½] phosphorylation in both cell lines . Positive_regulation EPHB2 PVR 15213219 1281529 similarly *enhanced* the platelet derived growth factor induced activation of the [Ras-Raf-MEK-ERK] signaling and shortened the period of the G ( 0 ) /G ( 1 ) phase of the cell cycle in NIH3T3 cells . Positive_regulation EPHB2 PXN 14636584 1171269 In the present study we demonstrate that HGF stimulates the localization of [ERK] to sites of cell-matrix interactions and that this is *mediated* by the tyrosine phosphorylation dependent association of inactive ERK and the focal adhesion complex protein . Positive_regulation EPHB2 PXN 14636584 1171273 These experiments reveal that *dependent* [ERK] activation at sites of cell-matrix interaction is critical for HGF stimulated epithelial morphogenesis . Positive_regulation EPHB2 PXN 15138291 1246202 Vinculin modulation of interactions *regulates* [ERK] to control survival and motility . Positive_regulation EPHB2 PXN 18045996 1861109 Indeed , we have shown that phosphorylation *promotes* [Erk] activation that in turn activates calpain . Positive_regulation EPHB2 PXN 20628053 2310206 Here we examine the nongenomic effects of dihydrotestosterone ( DHT ) in prostate cancer cells , focusing on how *mediates* [Erk] signaling and downstream physiologic actions . Positive_regulation EPHB2 PXN 20628053 2310209 Furthermore , EGFR induced [Erk] activation *requires* Src mediated phosphorylation of on tyrosines 31/118 . Positive_regulation EPHB2 PXN 20628053 2310213 In contrast , is not *required* for PKC induced [Erk] signaling . Positive_regulation EPHB2 RAB11A 23535298 2772540 Src family kinases (SFKs) regulate the completion of cytokinesis through signal transduction pathways that lead to the *dependent* phosphorylation of [ERK] and its localization to the midbody of cytokinetic cells . Positive_regulation EPHB2 RAB11A 23535298 2772543 We show that the midbody localization of UNC119a is dependent on Rab11 , and that knocking down UNC119a inhibits the *dependent* phosphorylation and midbody localization of [ERK] and cytokinesis . Positive_regulation EPHB2 RAB5A 24466349 2907865 Vinculin and were *involved* in the S. aureus induced phosphorylation of MAP kinases ( p38 , [Erk] , and JNK ) and IL-6 expression . Positive_regulation EPHB2 RABEPK 12871593 1114162 In addition , we show that *induced* the activation of both extracellular signal regulated kinase ( [ERK] ) and p38 mitogen activated protein kinase (MAPK) . Positive_regulation EPHB2 RABEPK 19306359 2127979 IL-12 ( 2 ) alone *induced* the activation of both extracellular signal regulated kinase ( [ERK] ) and p38 mitogen activated protein kinase (MAPK) . Positive_regulation EPHB2 RAC1 11453646 837052 is activated by tumor necrosis factor alpha and is *involved* in activation of [Erk] . Positive_regulation EPHB2 RAC1 11980921 934950 However , expression of the constitutively activated form of *restores* [Erk] nuclear localization , suggesting that adhesion dependent Rac activation is necessary to integrate signals directed to promote MAPK activity . Positive_regulation EPHB2 RAC1 12511425 1070794 We conclude from these data that dependent *activation* of [MAPK/ERK] is a critical event in the immediate phagocytic response of PMNs to microbial challenge . Positive_regulation EPHB2 RAC1 12546821 1051202 Activation of the [EphB] receptor *induces* translocation of the Rho-GEF kalirin to synapses and activation of and its effector PAK . Positive_regulation EPHB2 RAC1 17088251 1675907 We investigated whether Src and mediate deformation *induced* FAK and [ERK] phosphorylation and proliferation in human Caco-2 and rat IEC-6 intestinal epithelial cells . Positive_regulation EPHB2 RAC1 17438281 1729244 Chimaerin and *regulate* cell number , adherens junctions , and [ERK] MAP kinase signaling in the Drosophila eye . Positive_regulation EPHB2 RAC1 17940286 1835533 Instead , knock down of the novel oxidase Nox4 completely suppressed Tat dependent Ras and [ERK] *activation* downstream of and RhoA . Positive_regulation EPHB2 RAC1 21620958 2450425 Further , ET-1 increased ß ( 1 ) -integrin mRNA and protein expression via *dependent* [MEK/ERK] and EGF receptor-PI3K/Akt activation as shown by adenoviral dominant negative Rac1 or overexpression of copper/zinc-superoxide dismutase . Positive_regulation EPHB2 RAC1 21980400 2493082 Taken together , our study demonstrated that hypoxia induced HIF-1a expression involves a cascade of signaling events including ROS generation , activation of PI3K and [ERK] signaling , and subsequent *activation* of . Positive_regulation EPHB2 RAC1 22061968 2547663 *regulates* NT3 stimulated [Mek-Erk] signaling , directing marrow isolated adult multilineage inducible ( MIAMI ) cells toward an early neuronal phenotype . Positive_regulation EPHB2 RAC1 22511753 2624714 inhibition *prevented* [Erk] translocation and blocked proliferation . Positive_regulation EPHB2 RAC1 22617030 2614668 Autonomous [ERK] activation by uPAR *requires* H-Ras and . Positive_regulation EPHB2 RAC1 23817184 2815745 The results of the present study show that [ERK] could be *activated* by PI3 kinase , PDK1 , Akt , and and that alternatively , Akt and Rac1 could be activated by MEK and ERK in MSTO-211H cells . Positive_regulation EPHB2 RAC1 24327733 2880394 Expression of a constitutively active form of in these breast cancer models *blocked* PI3Ki induced down-regulation of [ERK] phosphorylation , apoptosis , and mitigated PI3K inhibitor sensitivity in vivo . Positive_regulation EPHB2 RAC1 9488437 488744 Fourth , Mas and strongly *activated* the JNK and p38 , but not [ERK] , mitogen activated protein kinases . Positive_regulation EPHB2 RAC2 11453646 837053 is activated by tumor necrosis factor alpha and is *involved* in activation of [Erk] . Positive_regulation EPHB2 RAC2 11980921 934951 However , expression of the constitutively activated form of *restores* [Erk] nuclear localization , suggesting that adhesion dependent Rac activation is necessary to integrate signals directed to promote MAPK activity . Positive_regulation EPHB2 RAC2 12511425 1070795 We conclude from these data that *dependent* activation of [MAPK/ERK] is a critical event in the immediate phagocytic response of PMNs to microbial challenge . Positive_regulation EPHB2 RAC2 17438281 1729245 Chimaerin and *regulate* cell number , adherens junctions , and [ERK] MAP kinase signaling in the Drosophila eye . Positive_regulation EPHB2 RAC2 22511753 2624715 inhibition *prevented* [Erk] translocation and blocked proliferation . Positive_regulation EPHB2 RAC3 11453646 837054 is activated by tumor necrosis factor alpha and is *involved* in activation of [Erk] . Positive_regulation EPHB2 RAC3 11980921 934952 However , expression of the constitutively activated form of *restores* [Erk] nuclear localization , suggesting that adhesion dependent Rac activation is necessary to integrate signals directed to promote MAPK activity . Positive_regulation EPHB2 RAC3 12511425 1070796 We conclude from these data that dependent *activation* of [MAPK/ERK] is a critical event in the immediate phagocytic response of PMNs to microbial challenge . Positive_regulation EPHB2 RAC3 17438281 1729246 Chimaerin and *regulate* cell number , adherens junctions , and [ERK] MAP kinase signaling in the Drosophila eye . Positive_regulation EPHB2 RAC3 22511753 2624716 inhibition *prevented* [Erk] translocation and blocked proliferation . Positive_regulation EPHB2 RAD50 11146560 760892 We provide evidence that mutants *promote* [ERK] activation and that the active protein induces a more sustained activation than the inactive protein . Positive_regulation EPHB2 RAD50 11228165 788437 is *involved* in cell stretching modulation of p38 but not [ERK] or JNK MAP kinase . Positive_regulation EPHB2 RAD50 11479306 860644 Moreover , inhibition of by a Rap1 GTPase activating protein-1 also *resulted* in a decrease in [ERK] and Akt phosphorylation , which was not further decreased by cAMP , suggesting that cAMP inhibits ERK and Akt by inhibiting Rap1 . Positive_regulation EPHB2 RAD50 11479306 860700 The *role* of in [ERK] and Akt activity was further demonstrated by our observation that an active form of Epac , which activated Rap1 in the absence of cAMP , increased ERK and Akt phosphorylation . Positive_regulation EPHB2 RAD50 11956184 953635 cAMP stimulated Ras independent and *dependent* [ERK] phosphorylation and cell proliferation in B-Raf expressing cells , but inhibited growth in B-Raf lacking cells . Positive_regulation EPHB2 RAD50 12402047 1009425 We conclude that cAMP induced regulation of [ERK] and *activation* of are independent processes . Positive_regulation EPHB2 RAD50 14551200 1175546 Experiments involving the expression of the dominant negative mutants of Ras and Rap1 signaling ( RasN17 or Rap1N17 ) indicate that both GTPases Ras and Rap1 are recruited for the ERK activation by VIP and PACAP38 , whereas is poorly *involved* in TRH or EGF induced [ERK] activation . Positive_regulation EPHB2 RAD50 14607972 1162191 Functionally , either interferes with Ras mediated ERK activation or *activates* [ERK] independently of Ras in a cell-context dependent manner . Positive_regulation EPHB2 RAD50 15167895 1259144 ARMS is rapidly tyrosine phosphorylated after binding of neurotrophins to Trk receptors and provides a docking site for the CrkL-C3G complex , resulting in *dependent* sustained [ERK] activation . Positive_regulation EPHB2 RAD50 15723799 1376774 Ras independent activation of [ERK] signaling via the torso receptor tyrosine kinase is *mediated* by . Positive_regulation EPHB2 RAD50 16507992 1529684 We confirm that the PKA independent activation of by Epac1 activates a perinuclear pool of Rap1 and that this does not *result* in [ERK] activation . Positive_regulation EPHB2 RAD50 17472964 1750451 Moreover , Ca2+ induced *activation* of [ERK] through and expression of loricrin were reduced in primary cultured nectin-1-/- keratinocytes ; Positive_regulation EPHB2 RAD50 20877310 2381758 Moreover , we found that negatively *regulated* GNDF induced [ERK] activation and neurite outgrowth . Positive_regulation EPHB2 RAD50 24523415 2924183 Moreover , our results showed that NMDA mediated activation of the small G-protein Ras is necessary for PI3K/Akt pathway activation , whereas was *involved* in NMDA phosphorylation of [ERK] . Positive_regulation EPHB2 RAF1 10376521 623370 Taxol induced apoptosis was associated with phosphorylation of both and Bcl-2 and *activation* of [ERK] and JNK MAP kinases . Positive_regulation EPHB2 RAF1 11088001 764961 We show that the activation of [ERK] via SSTR1 is mediated by the betagamma subunit of a pertussis toxin-sensitive G-protein and *requires* both the small G protein Ras and the serine/threonine kinase . Positive_regulation EPHB2 RAF1 11171046 783712 VEGF induced [ERK] activation and PGI ( 2 ) production were blocked by rottlerin , and VEGF *increased* association of PKCdelta with , the upstream activator of MEK . Positive_regulation EPHB2 RAF1 11604401 888250 [ERK] activation in *response* to constitutively active or growth factor stimulus was attenuated in cells expressing MKK1 C-terminal deletion mutants . Positive_regulation EPHB2 RAF1 11641250 872083 Stimulation of [Erk] activity was *due* to activation of Ras , , and MEK ( MAPK kinase ) . Positive_regulation EPHB2 RAF1 12821130 1104134 These results demonstrate that *dependent* [ERK] activation mediated by PTX-sensitive G protein coupled receptors may be a potent signal in S1P induced HCEC tube formation . Positive_regulation EPHB2 RAF1 12954639 1158148 This is the first demonstration that CaMKII interplays with Raf-1 and regulates [Erk] activation *induced* by Ras stimulated . Positive_regulation EPHB2 RAF1 14576068 1218551 is not *required* for megakaryocytopoiesis or TPO induced [ERK] phosphorylation . Positive_regulation EPHB2 RAF1 14670956 1210972 PKC/PKC alpha activity promoted GTP loading of Ras , *activation* of , and phosphorylation/activation of [ERK] . Positive_regulation EPHB2 RAF1 14719071 1197693 In cisplatin-resistant UM-SCC-23 in culture , which we have established , the protein levels of Ras , and MEK were drastically elevated compared to parent UM-SCC-23 , and [ERK] and Akt signals were constitutively *activated* . Positive_regulation EPHB2 RAF1 15009680 1217866 Activation of this conditionally active form of *induced* a sustained phosphorylation of [ERK] , and protected the cells from serum withdrawal induced cell death . Positive_regulation EPHB2 RAF1 15567062 1355337 The inhibitor , GW5074 , dose-dependently *blocked* strain induced [Erk] activation and Raf-1 phosphorylation . Positive_regulation EPHB2 RAF1 15749869 1379694 Although BCR induced c-Raf phosphorylation was also enhanced by prior CD40L treatment , was not *required* for [MEK/ERK] phosphorylation . Positive_regulation EPHB2 RAF1 16301319 1511040 These results demonstrate a regulatory role of Erbin in the Ras-Raf-MEK pathway , suggesting that Erbin may *inhibit* [ERK] activation by disrupting the interaction . Positive_regulation EPHB2 RAF1 16414982 1554062 Selective inhibitors ( ZM-336372 and Raf-1 inhibitor 1 ) significantly *attenuate* NaF induced [Erk] and caldesmon phosphorylation . Positive_regulation EPHB2 RAF1 16877565 1638803 However , inhibitors of and MEK or a dominant negative ERK mutant *blocked* FKN induced [ERK] , but not Akt and eNOS , phosphorylation . Positive_regulation EPHB2 RAF1 21831839 2473004 MAPK kinase ( MEK ) [/ERK] activation is *regulated* by interactions of with phosphatidylethanolamine binding protein 1 ( PEBP1 ) . Positive_regulation EPHB2 RAF1 21831839 2473006 siRNA knockdown of 15LO1 decreases the dissociation of from PEBP1 , and the resulting lower [ERK] *activation* leads to lower downstream IL-4Ra related gene expression . Positive_regulation EPHB2 RAF1 22826437 2670722 Furthermore , kinase activating mutants also *required* heterodimerization to enhance [MEK/ERK] activation . Positive_regulation EPHB2 RAF1 23118896 2696018 *Activation* of [ERK] by active was also prevented by RanBPM . Positive_regulation EPHB2 RAF1 23221422 2711117 Inhibition of Src or *blocked* LPS induced [ERK] activation . Positive_regulation EPHB2 RAF1 23359496 2743168 Although *triggers* transient [Erk] activation , B-Raf is implicated in sustained Erk signaling after TCR stimulation . Positive_regulation EPHB2 RAF1 23391722 2748221 Expression of mutant ( S259A ) in ECs *activated* [ERK] and induced SOX18 and PROX1 expression , leading to increased commitment of venous ECs to the lymphatic fate . Positive_regulation EPHB2 RAF1 24284076 2904574 *Activation* of [ERK] and RSK signaling by the expression of constitutively active suppresses the mutant phenotype in a RSK dependent manner . Positive_regulation EPHB2 RAF1 7957567 278070 We also show that ERK kinase activation precedes Raf-1 kinase hyperphosphorylation , suggesting that kinase activation is not *required* for [ERK] kinase activation . Positive_regulation EPHB2 RAF1 7992057 282963 *contributes* directly to [ERK] activation but not to JNK activation , whereas MEKK participated in JNK activation but caused ERK activation only after overexpression . Positive_regulation EPHB2 RAF1 9892010 586562 We show that the activation of [ERK] via SSTR1 is pertussis toxin sensitive and *requires* the small G protein Ras , phosphatidylinositol 3-kinase , the serine/threonine kinase , and the protein tyrosine phosphatase SHP-2 . Positive_regulation EPHB2 RAI1 16439309 1516600 Retinoic acid induces expression of SLP-76 : expression with c-FMS enhances [ERK] *activation* and differentiation/G0 arrest of HL-60 cells . Positive_regulation EPHB2 RAI14 16439309 1516599 Retinoic acid induces expression of SLP-76 : expression with c-FMS enhances [ERK] *activation* and differentiation/G0 arrest of HL-60 cells . Positive_regulation EPHB2 RAI2 16439309 1516601 Retinoic acid induces expression of SLP-76 : expression with c-FMS enhances [ERK] *activation* and differentiation/G0 arrest of HL-60 cells . Positive_regulation EPHB2 RALA 12488337 1032984 and 4-OHT each at 1 nM also *stimulated* [ERK] in a rapid transient manner . Positive_regulation EPHB2 RAN 22679017 2633353 Furthermore , ( K152A ) expression in the human mammary SKBR3 adenocarcinoma cell line gives rise to an enhanced transformed phenotype and *causes* a robust stimulation of both [ERK] and the N-terminal c-Jun kinase (JNK) . Positive_regulation EPHB2 RANBP2 21059916 2349517 Exposure to these exosomes *activated* the [ERK] and AKT signaling pathways in the recipient cells . Positive_regulation EPHB2 RANBP9 12147692 985224 We show that can *induce* GTP-Ras association and [Erk] phosphorylation and elevate serum response element-luciferase ( SRE-LUC ) expression , indicating that RanBPM can activate the Ras-Erk-SRE pathway . Positive_regulation EPHB2 RAPGEF1 15077165 1257686 Using full-length C3G and C3GDeltaCat mutant , lacking catalytic domain , we showed here that overexpression of cotransfected or C3GDeltaCat *inhibited* oncogenic Hraslys12 mediated phosphorylation of [ERK] , without altering Ras and Raf-1 kinase activation . Positive_regulation EPHB2 RAPGEF1 17825818 1810375 We hypothesize that *triggers* PP2A activation and binding to MEK and [ERK] at the subcortical actin cytoskeleton , thus favouring ERK dephosphorylation . Positive_regulation EPHB2 RAPGEF2 17724123 1789777 Thus , the interaction of with an internalized neurotrophin receptor transported to late endosomes *induces* sustained activation of both Rap1 and [ERK] and neurite outgrowth . Positive_regulation EPHB2 RAPGEF3 16507992 1529679 We confirm that the PKA independent activation of Rap1 by activates a perinuclear pool of Rap1 and that this does not *result* in [ERK] activation . Positive_regulation EPHB2 RAPGEF3 19423709 2096145 Activation of protein kinase Calpha by is *required* for the [ERK-] and CCAAT/enhancer binding protein beta dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells . Positive_regulation EPHB2 RASA1 20877310 2381759 Moreover , we found that negatively *regulated* GNDF induced [ERK] activation and neurite outgrowth . Positive_regulation EPHB2 RASD1 11751935 921990 While weakly *activates* [Erk] in the resting state , more potent effects are evident in the modulation of ligand stimulated receptor signal transduction , where Dexras1 functions as an inhibitor rather than activator of the Erk mitogen activated protein kinase signaling cascade . Positive_regulation EPHB2 RASGRF1 10455104 638411 This led to a significant reduction in both *dependent* [ERK] phosphorylation and AP1 dependent reporter gene activity . Positive_regulation EPHB2 RASGRF1 23145787 2722846 In the present study we characterized the *role* of in Ca2+ and [Ras?ERK] signalling after IL-1 stimulation . Positive_regulation EPHB2 RASGRF2 23145787 2722847 In the present study we characterized the *role* of in Ca2+ and [Ras?ERK] signalling after IL-1 stimulation . Positive_regulation EPHB2 RASGRP1 15899849 1408850 Analysis of a RasGRP1-deficient Jurkat T-cell clone and RasGRP1 RNA interference in wild-type cells revealed that is *required* for optimal , antigen receptor triggered [Ras-Erk] activation . Positive_regulation EPHB2 RASGRP1 17065239 1674896 Transfection of into resistant cells *enhances* PMA induced [Erk] activation . Positive_regulation EPHB2 RASGRP1 23308188 2725958 , but not RasGRP3 , is *required* for efficient thymic ß-selection and [ERK] activation downstream of CXCR4 . Positive_regulation EPHB2 RASGRP1 23308188 2725961 Also , we report that is *required* for [ERK] activation downstream of CXCR4 signaling , which we hypothesize represents a potential mechanism of RasGRP1 regulation of ß-selection . Positive_regulation EPHB2 RASGRP1 23589333 2789574 We previously described how alone *induces* analog [Ras-ERK] activation while SOS and RasGRP cooperate to establish bimodal ERK activation . Positive_regulation EPHB2 RASGRP2 23589333 2789575 We previously described how alone *induces* analog [Ras-ERK] activation while SOS and RasGRP cooperate to establish bimodal ERK activation . Positive_regulation EPHB2 RASGRP3 23308188 2725956 RasGRP1 , but not , is *required* for efficient thymic ß-selection and [ERK] activation downstream of CXCR4 . Positive_regulation EPHB2 RASGRP3 23589333 2789572 We previously described how alone *induces* analog [Ras-ERK] activation while SOS and RasGRP cooperate to establish bimodal ERK activation . Positive_regulation EPHB2 RASGRP4 23589333 2789573 We previously described how alone *induces* analog [Ras-ERK] activation while SOS and RasGRP cooperate to establish bimodal ERK activation . Positive_regulation EPHB2 RASSF5 15123616 1266631 Our functional studies show can *activate* JNK but not the [ERK] or the p38 MAP kinases , whereas its close homolog , TIGIRR , can not activate JNK . Positive_regulation EPHB2 RBBP4 22311972 2571414 Using pharmacological inhibitors , we demonstrate that enhanced co-stimulatory receptor phenotype of Nrf2 ( -/- ) iDC does not require [ERK] activity but is *dependent* on activity , indicating a potential interaction between Nrf2 function and HDAC . Positive_regulation EPHB2 RBBP7 22311972 2571415 Using pharmacological inhibitors , we demonstrate that enhanced co-stimulatory receptor phenotype of Nrf2 ( -/- ) iDC does not require [ERK] activity but is *dependent* on activity , indicating a potential interaction between Nrf2 function and HDAC . Positive_regulation EPHB2 RBMS1 18590724 1941312 In addition , *increased* the activation of [ERK] and Akt 30 min after Day-1 training in amygdala . Positive_regulation EPHB2 RD3 15102843 1258279 Our results show that Src , phosphatidylinositol 3-kinase , and atypical protein kinase C were commonly involved in D ( 2 ) mediated [ERK] *activation* . Positive_regulation EPHB2 REG1A 18388567 1907170 This study examined the *role* of in suppressed T-cell p-38 , [ERK] , and cytokine production after EtOH intoxication and burn injury . Positive_regulation EPHB2 REL 19621336 2118289 Inhibiting activity or knocking down c-Rel expression by RNA interference in colon cancer cells was *sufficient* to induce [EPHB2] expression . Positive_regulation EPHB2 RELA 11371570 834865 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and [ERK] and *activation* of cAMP-responsive element binding protein ( CREB ) , , and E2F ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation EPHB2 RELA 11447019 835454 Although ob/ob livers have significant histological liver injury and 11-fold greater serum alanine aminotransferase values than those of lean mice by 6 h post-LPS , they exhibit greater activation of AKT and [Erk] , more profound reductions in inhibitor kappa-B , enhanced *activation* of , and greater induction of NF-kappaB regulated genes . Positive_regulation EPHB2 RELA 12208854 998086 Granulocyte/macrophage-colony stimulating factor ( GM-CSF ) regulates lung innate immunity to lipopolysaccharide through [Akt/Erk] *activation* of and AP-1 in vivo . Positive_regulation EPHB2 RELA 12426209 1014367 Treatment of VSMCs with PDGF or EGF alone potently induced [ERK] phosphorylation and DNA synthesis but did not *induce* activation or iNOS expression . Positive_regulation EPHB2 RELA 15485634 1320646 CD40- and BAFF mediated survival is significantly increased in Act1-deficent B cells , with stronger IkappaB phosphorylation , processing of ( p100/p52 ) , and *activation* of JNK , [ERK] , and p38 pathways , indicating that Act1 negatively regulates CD40- and BAFF mediated signaling events . Positive_regulation EPHB2 RELA 15843535 1398458 To identify a molecular basis for this receptor cross-talk , we examined [ERK] activation and *induction* . Positive_regulation EPHB2 RELA 15878976 1445444 Induction of Bcl10 activity caused rapid activation of and c-Jun N-terminal kinase (JNK) , but not *activation* of extracellular signal regulated kinase ( [ERK] ) or p38 mitogen activated protein ( MAP ) kinases . Positive_regulation EPHB2 RELA 16436136 1516432 The induction of RANTES by SCF or TNF-alpha was mediated by ERK and , respectively , and SCF induced MIP-1beta release was *mediated* by [ERK] . Positive_regulation EPHB2 RELA 16709941 1584712 Increased expression of and *activation* of extracellular signal regulated kinase ( [ERK] ) were demonstrated in SM22-PAI+-VSMCs ( fold=NF-kappaB=2.2+/-0.1 , fold=phosphorylated-ERK=1.6+/-0.1 ) . Positive_regulation EPHB2 RELA 16870149 1593096 However , this activation of *requires* the PI3K and PKC signaling pathways , but not [ERK] or JNK . Positive_regulation EPHB2 RELA 17499198 1739928 Molecular mechanisms that govern attenuation of the levels of mRNAs and proteins of these cytokines and iNOS revealed that the PC extract inhibited LPS stimulated phosphorylation of [ERK] and *activation* of . Positive_regulation EPHB2 RELA 17602748 1842183 Reverse signaling initiated from GITRL *induces* activation through [ERK] in the inflammatory activation of macrophages . Positive_regulation EPHB2 RELA 18401006 1925770 CyaA enhanced LPS induced phosphorylation of p38 MAPK and [ERK] in DC , and inhibitors of p38 MAPK , MEK , or *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation EPHB2 RELA 18442745 1900569 SNP induced the phosphorylation of p38 MAPK and [extracellular regulated kinase (ERK)] , degradation and phosphorylation of IkappaB , and *activation* of . Positive_regulation EPHB2 RELA 18603343 1935575 Hydrogen peroxide provoked phosphorylation of [extracellular regulated kinase (ERK)] and c-Jun NH ( 2 ) -terminal kinase ( JNK ) , and *activation* of . Positive_regulation EPHB2 RELA 19429670 2106915 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either [ERK] *inhibitor* , p38MAPK inhibitor or inhibitor . Positive_regulation EPHB2 RELA 19619321 2118168 Unlike Paclitaxel , ARRY-520 did not induce activation , did not enhance cytokine secretion , nor *induce* [ERK] phosphorylation in Type I EOC cells . Positive_regulation EPHB2 RELA 20054486 2177437 HF6-FC exerts its inhibitory effects by suppression of p38 and but *activation* of [ERK] . Positive_regulation EPHB2 RELA 20127676 2242102 This effect did not appear to be mediated via effects on early markers of neutrophil activation ( e.g. surface marker expression , shape change , aggregation and superoxide anion generation ) , by direct inhibition of activation ( assessed by cytoplasmic IkappaBalpha proteolysis and NF-kappaB p65 subunit translocation ) and [ERK] *activation* ( determined by specific ERK phosphorylation ) but due to down-regulation ( at protein and mRNA level ) of the survival protein Mcl-1 but not the pro-apoptotic bcl-2 homologue Bim . Positive_regulation EPHB2 RELN 16514107 1671788 Although rat sarcoma viral oncogene was weakly activated upon Reelin treatment , pharmacological inhibition of the PI3K pathway blocked *dependent* [ERK] activation , which indicates cross talk between the ERK and PI3K pathways . Positive_regulation EPHB2 RELN 16514107 1671811 Our findings demonstrate that *triggers* [ERK] signaling in an SFK/mDab1- and PI3K dependent manner and that ERK activation is required for Reelin dependent transcriptional activation and the detachment of neurons migrating from the SVZ . Positive_regulation EPHB2 RELN 23318582 2758239 *induces* [EphB] activation . Positive_regulation EPHB2 RENBP 12962137 1138501 In proliferating MC3T3E1 pre-osteoblasts , 24-72 h exposure to AGEs did not modify expression of RAGE , [ERK] *activation* or the cellular density of binding sites . Positive_regulation EPHB2 RENBP 20638679 2504600 To delineate the underlying molecular mechanism , we showed that *increased* phosphorylation of p44/42 [ERK] , p38 , JNK , and PI3K in macrophages . Positive_regulation EPHB2 RENBP 24733604 2949956 *increased* the phosphorylation of [ERK] , and IKK and also DNA binding ability of SREBP , thereby its dependent gene transcription . Positive_regulation EPHB2 RET 16254036 1508544 To determine the key RAF isoform mediating *induced* [ERK] phosphorylation , we stably transfected doxycycline-inducible RET/PTC3 expressing thyroid PCCL3 cells with small interfering RNA vectors to induce selective knockdown of BRAF or CRAF . Positive_regulation EPHB2 RET 16254036 1508546 Conditional expression *induced* comparable ERK phosphorylation in CRAF knockdown and control cells but negligible [ERK] phosphorylation in BRAF knockdown cells . Positive_regulation EPHB2 RET 18004977 1835817 Only one line had thyroid targeted , doxycycline regulated RET/PTC1 and luciferase coexpression , in which doxycycline induction of *led* to [Erk] phosphorylation and reduced expression of the sodium/iodide symporter ( NIS ) . Positive_regulation EPHB2 RETNLB 16243841 1489579 Furthermore , it was shown that acutely and markedly *activates* [ERK] and p38 , while weakly activating JNK , in primary cultured hepatocytes . Positive_regulation EPHB2 RGS2 24973550 2952523 Overexpression of in HEK293 cells , a human embryonic kidney cell line , and RAW264.7 cells , a monocyte/macrophage line , *inhibited* the AngII induced activation of [ERK] and increase of CXCR4 expression . Positive_regulation EPHB2 RHO 10022875 590379 All combinations of Rac/Raf and Ras/Raf and effector mutants that transform cells cooperatively *stimulated* [ERK] . Positive_regulation EPHB2 RHO 11715015 881611 The expression of cyclin D1 in mid-G1 phase is associated with sustained ERK activity , and we show here that is *required* for the sustained [ERK] signal . Positive_regulation EPHB2 RHO 12546821 1051166 Rapid induction of dendritic spine morphogenesis by trans-synaptic [ephrinB-EphB] receptor *activation* of the kalirin . Positive_regulation EPHB2 RHO 12730329 1112886 Surprisingly , functional inhibition of , in C3-exotoxin lipofected cells , markedly *reduced* LPA stimulated phosphorylation of [ERK] , without affecting the EGF induced stimulation of MAPK . Positive_regulation EPHB2 RHO 15840582 1418285 dependent stress fiber accumulation *promotes* the sustained activation of [ERK] and subsequent cyclin D1 expression during G ( 1 ) -S phase cell cycle progression . Positive_regulation EPHB2 RHO 18255094 1877252 Thus , two distinct pathways involving the [EGFR/pp60(c-src)/MEK-ERK] pathway and dependent SMAD2 *activation* are required for TGF-beta1 induced PAI-1 expression in VSMC . Positive_regulation EPHB2 RHOA 11805108 922423 Paradoxically , Y-27632 and *increased* [ERK] phosphorylation in MCF-7 cells , providing further evidence that ERK activation alone does not promote cell migration when Rho kinase is antagonized . Positive_regulation EPHB2 RHOA 12574121 1057744 The inhibition of activity in animal caps significantly *prevents* the [EphB2-] and ephrin-B1 mediated cell sorting . Positive_regulation EPHB2 RHOA 12874183 1120958 The purpose of this investigation was to examine whether *regulates* [ERK] downstream signaling and cellular proliferation through its effects on the cytoskeleton and the nuclear localization of ERK . Positive_regulation EPHB2 RHOA 14569089 1155515 In primary rat MC subjected to cyclic mechanical strain , activity was maximally increased ( 2.4-fold ) after 1 min of stretch , and [Erk] activation temporally *followed* . Positive_regulation EPHB2 RHOA 14569089 1155516 The authors conclude that the early activation of is *essential* for stretch induced actin stress fiber formation and [Erk] activation in MC , events which are prevented by NO and cGMP through their action on RhoA . Positive_regulation EPHB2 RHOA 15494214 1354855 The data indicate that [ERK] activation is essential for phenylephrine stimulation of NHE1 , and that ERK and are *involved* in LPA stimulation of NHE1 by more than one mechanism . Positive_regulation EPHB2 RHOA 15855657 1439599 Overexpression of a constitutively active as well as inhibition of Rho associated kinase *blocked* complement mediated [ERK] activation . Positive_regulation EPHB2 RHOA 17940286 1835532 Instead , knock down of the novel oxidase Nox4 completely suppressed Tat dependent Ras and [ERK] *activation* downstream of Rac1 and . Positive_regulation EPHB2 RHOA 19074159 2030553 Our results indicated possible *roles* of in affecting [ERK] activities via MEKK1 mediated crosstalk , which seems to be supported by indications from several experimental studies that may also implicate the collective regulation of cell fate and progression of cancer and other diseases . Positive_regulation EPHB2 RHOA 19113908 2060699 Inhibition of and ROCK in MC3T3-E1 pre-osteoblasts cultured on substrates of varying compliance *reduced* [ERK] activity , whereas constitutively active RhoA enhanced it . Positive_regulation EPHB2 RHOA 19940066 2210158 Collectively , data on *induced* changes in actomyosin contractile activity , ECM synthesis/assembly , and [Erk] activation , along with fibronectin induced alpha-SMA expression in TM cells , reveal a potential molecular interplay between actomyosin cytoskeletal tension and ECM synthesis/assembly . Positive_regulation EPHB2 RIC8A 15802611 1417438 also *enhanced* [ERK] activation by the G ( i ) -linked G protein coupled receptor agonist lysophosphatidic acid . Positive_regulation EPHB2 RICTOR 20512842 2270566 In this report , we focused on studying the *role* of mTORC1 and in rapamycin mediated Akt and [ERK] phosphorylation , and the antitumor effect of rapamycin in cancer cells in combination with Akt and ERK inhibitors . Positive_regulation EPHB2 RLF 10442634 635711 Finally , while does not *increase* [Erk] activity , inhibition of MEK blocks both Ras- as well as Rlf-CAAX induced differentiation , suggesting that RalGEFs induce PrE differentiation in a manner depending on basal MEK or Erk activity . Positive_regulation EPHB2 RMDN3 18771726 1980330 We demonstrated here , that PTPIP51 could regulate ERK activity on Raf level , since MEK inhibitor and dominant negative Raf-1 but not Ras could inhibit the [ERK] activation *induced* by . Positive_regulation EPHB2 ROCK1 18255094 1877253 Thus , two distinct pathways involving the [EGFR/pp60(c-src)/MEK-ERK] pathway and dependent SMAD2 *activation* are required for TGF-beta1 induced PAI-1 expression in VSMC . Positive_regulation EPHB2 ROCK1 18695640 1973875 also *potentiated* 5-HT(1B) receptor stimulated [ERK] activation and proliferation in vitro by facilitating MEK-ERK interaction . Positive_regulation EPHB2 ROCK1 19113908 2060697 Inhibition of RhoA and in MC3T3-E1 pre-osteoblasts cultured on substrates of varying compliance *reduced* [ERK] activity , whereas constitutively active RhoA enhanced it . Positive_regulation EPHB2 ROCK1 21849669 2495963 RhoA , inhibition , or RhoA , ROCK1 , ROCK2 , mDia1 , and FAK reduction by siRNA *blocked* deformation induced nuclear [ERK] phosphorylation without preventing ERK phosphorylation in the cytoplasmic protein fraction . Positive_regulation EPHB2 ROCK1 22215561 2537687 *induces* [ERK] nuclear translocation in PDGF-BB stimulated migration of rat vascular smooth muscle cells . Positive_regulation EPHB2 ROCK2 18255094 1877254 Thus , two distinct pathways involving the [EGFR/pp60(c-src)/MEK-ERK] pathway and dependent SMAD2 *activation* are required for TGF-beta1 induced PAI-1 expression in VSMC . Positive_regulation EPHB2 ROCK2 18695640 1973876 also *potentiated* 5-HT(1B) receptor stimulated [ERK] activation and proliferation in vitro by facilitating MEK-ERK interaction . Positive_regulation EPHB2 ROCK2 19113908 2060698 Inhibition of RhoA and in MC3T3-E1 pre-osteoblasts cultured on substrates of varying compliance *reduced* [ERK] activity , whereas constitutively active RhoA enhanced it . Positive_regulation EPHB2 ROCK2 21849669 2495964 RhoA , inhibition , or RhoA , ROCK1 , ROCK2 , mDia1 , and FAK reduction by siRNA *blocked* deformation induced nuclear [ERK] phosphorylation without preventing ERK phosphorylation in the cytoplasmic protein fraction . Positive_regulation EPHB2 RPGR 19664651 2138661 PF could also reverse the CRD evoked increased glutamate concentration by CRD as shown by dynamic microdialysis monitoring in ACC , whereas , DPCPX , an antagonist of adenosine A(1) receptor , significantly blocked the analgesic effect of PF and PF 's inhibition on *induced* [p-ERK] and p-CREB expression . Positive_regulation EPHB2 RPS27 21889435 2510805 Overexpression of resulted in decreased fibroblast growth factor ( FGF2 ) receptor 3 and *impaired* endogenous [MAPK/ErK] signaling . Positive_regulation EPHB2 RPS6KA1 10469565 641231 Nevertheless , activation of full-length in the absence of serum *required* activation by both PDK1 and [ERK] . Positive_regulation EPHB2 RPS6KA1 10469565 641235 Activation of phosphotransferase activity of full-length in vivo *requires* both PDK1 and [ERK] . Positive_regulation EPHB2 RPS6KA3 18077417 1834331 Therefore , PEA-15 functions as a scaffold to enhance [ERK] *activation* of , and this activity is regulated by phosphorylation . Positive_regulation EPHB2 RPS6KA5 10625698 658948 Stimulation of in contracting skeletal muscle *required* the activation of both [ERK] and p38 ( MAPK ) . Positive_regulation EPHB2 RPS6KA5 17397860 1735732 Since CREB is a downstream target of MSK-1 ( mitogen- and stress activated protein kinase-1 ) situated at the crossroad of ERK ( extracellular receptor kinase ) and p38MAPK signaling pathways , we reasoned that could be a downstream molecular *target* for p38MAPK and [ERK] signaling in the IPC hearts . Positive_regulation EPHB2 RPSA 19998339 2272057 [ERK/MAPK] activation *involves* hypoxia induced expression and contributes to apoptosis resistance in gastric cancer . Positive_regulation EPHB2 RPTOR 20512842 2270567 In this report , we focused on studying the *role* of and mTORC2 in rapamycin mediated Akt and [ERK] phosphorylation , and the antitumor effect of rapamycin in cancer cells in combination with Akt and ERK inhibitors . Positive_regulation EPHB2 RPTOR 20512842 2270614 We found that low concentrations rapamycin increased Akt and ERK phosphorylation through a mTORC1 dependent mechanism because knockdowned *induced* the activation of Akt and [ERK] , but higher doses of rapamycin inhibited Akt and ERK phosphorylation mainly via the mTORC2 signaling pathway because that the silencing of rictor led to the inhibition of Akt and ERK phosphorylation . Positive_regulation EPHB2 RRM1 23922955 2826412 Furthermore , inhibition of by siRNA significantly *reduced* the dNTP pool , Ras/Raf and MMP-9 activities and the levels of p-MEK , [p-ERK] and NF-?B , resulting in growth retardation and reduced invasion in AGS and NCI-N87 cells . Positive_regulation EPHB2 RUNX2 17490811 1739386 Taken together , the excitation of CCD neurons might be attributed to the *induced* activation of [ERK] , which suppressed the A-type fast inactivating potassium conductance in CCD neurons . Positive_regulation EPHB2 RYR3 18199822 1876288 Thus superoxide induced potentiation requires the redox targeting of and the subsequent *activation* of [ERK] . Positive_regulation EPHB2 S100A8 15798102 1390461 Higashi et al. now demonstrate that dependent SHP-2 activation *leads* to sustained activation of [ERK] ( extracellular signal regulated kinase ) , culminating in morphological changes that mimic unrestrained stimulation by growth factors . Positive_regulation EPHB2 S100A8 19672789 2162810 The interaction of alphaPix with *activates* PAK1 , [ERK] and NF-kappaB , which induces IL-8 expression in H. pylori infected gastric epithelial cells . Positive_regulation EPHB2 S100A8 20855497 2325781 Upon delivery into epithelial cells , causes loss of polarity and *activates* aberrant [Erk] signaling . Positive_regulation EPHB2 S100A8 20855497 2325782 We show that *induced* [Erk] activation results in senescence and mitogenesis in nonpolarized and polarized epithelial cells , respectively . Positive_regulation EPHB2 S100A9 23682982 2823396 In addition , *caused* a significant increase in [extracellular regulated kinase (ERK)1/2] mitogen activated protein kinase (MAPK) phosphorylation , while the status of p38 and c-Jun N-terminal kinase (JNK) phosphorylation remained unchanged . Positive_regulation EPHB2 S100B 10757524 682890 Here we report that significantly *increases* the activity of [ERK] in primary cultures of astrocytes , a result which may be related to previous observations of the effect of this protein on glial proliferation . Positive_regulation EPHB2 S100G 19796047 2153740 Over-expression of *caused* an increase in [p-ERK] . Positive_regulation EPHB2 S100P 17587138 1768087 These data indicate that S100P is expressed at greater levels in colon cancer than matched normal tissue and that *stimulates* colon cancer cell growth , migration , [Erk] phosphorylation , and NFkappaB activation in vitro , suggesting that this ligand/receptor pair may be targeted for the development of new therapies . Positive_regulation EPHB2 S1PR3 21749389 2452457 The use of specific receptor antagonists indicated that the receptor was dominantly *involved* in S1P induced [ERK] activation and hypopigmentation . Positive_regulation EPHB2 SAA1 15724247 1376868 dependent IL-8 gene expression *required* activation of the MAPK [ERK] , p38 and JNK in HT-29 cells . Positive_regulation EPHB2 SAA1 20177146 2242723 Inactivation of G ( ( i ) ) protein ( s ) by PTX inhibited the activation of *induced* [ERK] , but not p38 MAPK or JNK . Positive_regulation EPHB2 SALL1 16049179 1438414 These results clarify findings from a previous study showing that [ERK] activation *induced* with is resistant to 2-amino-5-phosphonovalerate , in contrast to that induced with 5 or 100 Hz stimulation , which is sensitive . Positive_regulation EPHB2 SCARB1 19169357 2027671 Competition , inhibition or knockdown of *impaired* the PPM dependent apoB trafficking and [ERK] activation . Positive_regulation EPHB2 SCRIB 20622900 2321779 In human keratinocytes , loss of *results* in elevated [phospho-ERK] levels and concomitant increased nuclear translocation of phospho-ERK . Positive_regulation EPHB2 SCRIB 20622900 2321784 These results provide a clear mechanistic explanation of how can *regulate* [ERK] signalling and begin to explain how loss of hScrib during cancer development can contribute to disease progression . Positive_regulation EPHB2 SDC1 16741952 1624897 Activation of [ERK] signaling upon alternative protease nexin-1 internalization *mediated* by . Positive_regulation EPHB2 SEA 11850798 913010 A dominant negative form of Ras inhibited *induced* [ERK] phosphorylation in concentration dependent manner suggesting the importance of the Grb2-Ras signaling axis in V-SEA induced ERK activation . Positive_regulation EPHB2 SEC61B 10648884 662339 depolarization *induced* calcium increases activated both [ERK] and p38 kinase within 5 min . Positive_regulation EPHB2 SELE 16715142 1631454 On the other hand , the *activation* of [ERK] by modulates the opening of interendothelial spaces by initiating the activation of Src kinase activities and the dissociation of the VE-cadherin/beta-catenin complex . Positive_regulation EPHB2 SELE 16982754 1617159 Thereafter , we accumulated several results , suggesting that DR3 is an E-selectin receptor on colon cancer cells and that its activation by *triggers* the activation of p38 and extracellular signal regulated kinase ( [ERK] ) mitogen activated protein kinase (MAPK) and confers migration and survival advantages . Positive_regulation EPHB2 SELE 20817864 2325085 HUVEC treatment with ICOS-Fc did not modulate expression of adhesion molecules and cytokines , but it substantially downmodulated [ERK] phosphorylation *induced* by triggering or osteopontin , which may influence HUVEC adhesiveness . Positive_regulation EPHB2 SELPLG 22311979 2571418 In addition , but through a distinct pathway , engagement *activates* [ERK] . Positive_regulation EPHB2 SELPLG 22311979 2571419 Importantly , EBS deletion or Arg-337 and Lys-338 mutations abrogated *induced* [ERK] activation , whereas they did not prevent Syk phosphorylation or E-selectin induced leukocyte slow rolling . Positive_regulation EPHB2 SEPP1 21893096 2496540 Furthermore , the *activation* of [Erk] phosphorylation and the NFAT promoter by promoted the transcription and expression of downstream gene IL-2 . Positive_regulation EPHB2 SERPINA12 23135225 2735656 Vaspin stimulated the phosphorylation of ERK , and pretreatment of hOBs with the ERK inhibitor PD98059 blocked the *induced* activation of [ERK] , however , vaspin did not stimulate the phosphorylation of p38 , JNK or Akt . Positive_regulation EPHB2 SERPINE1 11266465 796858 In MCF-7 cells , did not directly *activate* the mitogen activated protein ( MAP ) kinases , extracellular signal regulated kinase ( [ERK] ) 1 and ERK2 , but instead altered the response to uPA so that ERK phosphorylation was sustained . Positive_regulation EPHB2 SERPINE1 11266465 796864 [ERK] phosphorylation was not *induced* by tissue-type plasminogen complex or by uPA-PAI-1 complex in the presence of antibodies that block uPA binding to uPAR . Positive_regulation EPHB2 SERPINE1 18061125 1846787 Ox-LDL stimulation of ( PAI-1 ) expression via transforming growth factor-beta ( TGF-beta ) /Smad signaling in mesangial cells *required* activation of extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 SET 15703833 1372697 By contrast , knocking down I-2PP2A/SET by siRNA resulted in enhancement of ERK and MEK activations , suggesting that negatively *regulates* [MEK/ERK] . Positive_regulation EPHB2 SETD2 21984126 2493358 In contrast , forced expression of DUSP2 under hypoxia abolishes *induced* [ERK] phosphorylation and COX-2 expression . Positive_regulation EPHB2 SETD2 22771629 2639530 Notoginsenoside Ft1 promotes angiogenesis via *mediated* VEGF secretion and the regulation of PI3K/AKT and [Raf/MEK/ERK] signaling pathways . Positive_regulation EPHB2 SF1 17312106 1699618 The *induced* weak activation of p38 , but not [ERK] or cytokine mRNA . Positive_regulation EPHB2 SFN 24952354 2952351 Pretreatment with NAC ( N-acetyl-l-cysteine ) , a well-known antioxidant , completely blocked the *induced* increase in LC3-II levels and activation of [ERK] . Positive_regulation EPHB2 SFPQ 22536447 2590081 is *essential* for translocation of NF-?B and [ERK] to the nucleus . Positive_regulation EPHB2 SFRP1 20595636 2296426 In contrast , *activated* [ERK] and up-regulated MMP1 and MMP9 without altering TIMP1 production when expressed in human lung epithelial cells . Positive_regulation EPHB2 SFTPC 16524430 1531537 These results suggest that the ERK pathway is involved in the melanogenic signaling cascade , and that [ERK] *activation* by reduces melanin synthesis via MITF downregulation . Positive_regulation EPHB2 SFTPC 21368227 2404229 treatment caused the activation of NF-?B and AP-1 , which are essential for SPC induced CCL2 production , and *induced* the activation of three MAPKs , [ERK] , p38 MAPK , and JNK . Positive_regulation EPHB2 SFTPC 22544520 2618722 In the present study , we confirmed that *activated* [ERK] and that a specific inhibitor of the ERK pathway ( PD98059 ) recovered SPC induced hypopigmentation . Positive_regulation EPHB2 SGK1 16553792 1538050 Furthermore , [ERK] *activation* of is involved in spatial memory formation in rats . Positive_regulation EPHB2 SHC1 10400627 628253 These findings strongly support distinct *roles* for Grb2 and in controlling [ERK] and JNK activation after EGF stimulation . Positive_regulation EPHB2 SHC1 10675331 667818 In contrast , c-Src activated by isoproterenol led to tyrosine phosphorylation of and subsequent [Erk] *activation* , but not tyrosine phosphorylation of cortactin or Stat3 . Positive_regulation EPHB2 SHC1 10976990 729629 In contrast to their implication in epidermal growth factor (EGF) receptor tyrosine kinase signaling , the adaptor protein , the Grb2/Sos complex , and the small G protein Ras were not *involved* in the activation of [Erk] induced by either LPA or PGF2alpha in MC3T3-E1 cells , suggesting that activation of Erk by Gi and Gq protein coupled receptors is Ras independent in these cells . Positive_regulation EPHB2 SHC1 11509615 848598 Using IL-2R mutants and specific pharmacologic inhibitors , we found that the PI3K , but not [Erk] , pathway is *required* for maximal induction of c-myc , cyclin D2 , cyclin D3 , cyclin E , and bcl-x ( L ) by . Positive_regulation EPHB2 SHC1 11562449 862834 Moreover , PP2 ( 20 nM ) , an inhibitor of Src , blocked D ( 4 ) receptor mediated phosphorylation and [ERK] *activation* . Positive_regulation EPHB2 SHC1 14576154 1199909 Non-redundant *role* of in [Erk] activation by cytoskeletal reorganization . Positive_regulation EPHB2 SHC1 17222183 1689170 Induction of uPA gene expression by the blockage of E-cadherin via Src- and *dependent* [Erk] signaling . Positive_regulation EPHB2 SHC1 18333755 1925139 The shear activations of [ERK] , JNK , and p38 were *mediated* by integrins and , and these pathways differentially modulated the downstream bone formation related gene expression . Positive_regulation EPHB2 SHC1 23584453 2778478 Thus , in addition to its established role in promoting MAP kinase signaling in stimulated cells , negatively *regulates* [Erk] activation in the absence of growth factors and thus could be considered a tumor suppressor in human cells . Positive_regulation EPHB2 SHC1 9710602 526844 The arsenite induced tyrosine phosphorylation of Shc , enhancement of and Grb2 interactions , and *activation* of [ERK] were all drastically reduced by treatment of cells with either the general growth factor receptor poison suramin or the EGFR-selective inhibitor tyrphostin AG1478 . Positive_regulation EPHB2 SHH 16630542 1552121 In addition , as well as calcium ionophore A32187 rapidly *activated* [ERK] . Positive_regulation EPHB2 SHH 16630542 1552123 On the other hand , although Shh induced Gli-1 nuclear accumulation in RGM-1 cells , *activated* [ERK] even in cells pretreated with actinomycin D . Positive_regulation EPHB2 SHH 17385725 1727720 We examined early signaling events in the CB/CMZ and found that FGF2 or *induced* a robust [Erk] phosphorylation during the early stages of retina regeneration . Positive_regulation EPHB2 SHH 17688959 1794282 Most importantly , we report that *induces* [MAPK/ERK] and phosphoinositide 3-kinase (PI3K) dependent Akt phosphorylation and that activation of both signaling pathways is essential for Shh 's signaling in muscle cells . Positive_regulation EPHB2 SHH 17688959 1794305 By exploiting specific chemical inhibitors of the MAPK/ERK and PI3K/Akt signaling pathways , UO126 and Ly294002 , respectively , we demonstrate that *induced* Akt phosphorylation , but not that of [MAPK/ERK] , is required for its promotive effects on muscle cell proliferation and differentiation . Positive_regulation EPHB2 SHH 20451654 2288389 *Activation* of [Erk] by independent of canonical hedgehog signalling . Positive_regulation EPHB2 SHOC2 20051520 2211688 positively *regulates* [Ras/ERK] MAP kinase signaling by serving as a scaffold for Ras and Raf . Positive_regulation EPHB2 SIAH1 23891150 2830297 X-ray crystallography , mass spectrometry , and functional data demonstrate that these peptide mimetics are efficient covalent inhibitors of Siah and antagonize *dependent* regulation of [Erk] and Hif signaling in the cell . Positive_regulation EPHB2 SIAH2 23891150 2830298 X-ray crystallography , mass spectrometry , and functional data demonstrate that these peptide mimetics are efficient covalent inhibitors of Siah and antagonize *dependent* regulation of [Erk] and Hif signaling in the cell . Positive_regulation EPHB2 SIAH3 23891150 2830299 X-ray crystallography , mass spectrometry , and functional data demonstrate that these peptide mimetics are efficient covalent inhibitors of Siah and antagonize *dependent* regulation of [Erk] and Hif signaling in the cell . Positive_regulation EPHB2 SIGLEC8 23684072 2819372 In contrast , an ROS inhibitor prevented the *induced* enhancement of [ERK] phosphorylation and cell death . Positive_regulation EPHB2 SIGLEC8 23684072 2819374 In activated eosinophils ligation of *leads* to ROS dependent enhancement of IL-5 induced [ERK] phosphorylation , which results in a novel mode of biochemically regulated eosinophil cell death . Positive_regulation EPHB2 SIL1 18406507 1907492 also *activated* p38 MAPK and [ERK] , but not JNK , at 6h after exposure . Positive_regulation EPHB2 SIRPA 18218778 1864071 Anoikis effector negatively *regulates* [Erk] activity . Positive_regulation EPHB2 SIRPA 18218778 1864074 Knocking down expression in cultured cells *resulted* in increased [Erk] activation , and partially knocking down Erk reversed the increased anoikis resistance of Bit1 knockdown . Positive_regulation EPHB2 SIRT1 21697093 2465463 activation *promotes* induction of [ERK] and p38 kinase activities , but not JNK , in response to IL-1ß . Positive_regulation EPHB2 SIRT1 21697093 2465469 Subsequently , [ERK] and p38 kinase activated by SIRT1 also *induce* activation , forming a positive feedback loop to sustain downstream signaling of these kinases . Positive_regulation EPHB2 SKP1 11412047 828331 *induced* a rapid and transient activation of [ERK] and p38 in a dose dependent manner . Positive_regulation EPHB2 SKP1 15465815 1342227 These data suggest that Spred-1 negatively regulates hematopoiesis by suppressing not only *induced* but also IL-3 induced [ERK] activation . Positive_regulation EPHB2 SKP1 19956885 2185002 LY294002 and PD98059 inhibited *induced* Akt and [Erk] activation in H209 cells , respectively . Positive_regulation EPHB2 SKP1 21330471 2415113 Half the population phosphorylated [Erk] in *response* to between 0.9 and 1.2 minutes , and S6 phosphorylation followed approximately a minute later ( t & frac12 ; ( pS6 rise ) = 2.2-2.7 minutes ) . Positive_regulation EPHB2 SKP2 17314399 1711562 Mechanistic analysis showed that the [ERK] effect on p27kip1 is *mediated* by and is secondary to its effect on cyclin D1 . Positive_regulation EPHB2 SLAMF1 23125442 2721589 Moreover , the majority of IFN-? producing T cells expressed signaling lymphocyte activation molecule ( SLAM ) , and activation further *increased* [ERK] phosphorylation . Positive_regulation EPHB2 SLC17A5 24567111 2919402 The data revealed that improved the rats learning and memory abilities , attenuated neuronal cells apoptosis , *increased* the expression of [p-ERK] and p-Akt , and decreased the expression of p-JNK . Positive_regulation EPHB2 SLC22A3 17267741 1704190 These findings support important profibrotic roles for plasmin that include PAR-1 dependent [ERK] signaling and *induction* . Positive_regulation EPHB2 SLC25A16 24129679 2875088 In contrast , *induced* [ERK] activation and tumorigenesis in B-Raf-deficient epidermis , whereas C-Raf ablation blocked GDC-0879 induced tumorigenesis ( despite strong ERK activation ) by preventing Roka mediated keratinocyte dedifferentiation . Positive_regulation EPHB2 SLC2A4RG 12546821 1051167 Rapid induction of dendritic spine morphogenesis by trans-synaptic [ephrinB-EphB] receptor *activation* of the kalirin . Positive_regulation EPHB2 SLC30A1 22572848 2625048 As expected , also *enhanced* [ERK] phosphorylation . Positive_regulation EPHB2 SLC30A1 22572848 2625050 Coexpression of ZnT-1 and nonactive Raf-1 blocked the *mediated* [ERK] phosphorylation and abolished the ZnT-1 induced augmentation of I ( caT ) . Positive_regulation EPHB2 SLC33A1 17212359 1717695 *Activation* of [ERK] , JNK , Akt , and G-protein coupled signaling by hybrid angiotensin II B2 receptors expressed in HEK-293 cells . Positive_regulation EPHB2 SLC33A1 18372234 1888317 Cardiac receptor protein levels were unchanged but the levels of phosphorylated ( p ) [ERK] and Jun-NH ( 2 ) -protein kinase ( JNK ) were *increased* in D and DS . Positive_regulation EPHB2 SLC33A1 20353822 2260869 Hyperoxia induced Ang II type 1 receptor (AT1R) expression but did not alter AT2R expression , furthermore , silencing of signaling with small interfering RNA *suppressed* hyperoxia induced [phosphorylated-ERK] ( p-ERK ) 1/2 , alpha-SMA , and collagen type I expression . Positive_regulation EPHB2 SLC33A1 20492449 2283509 In contrast , the IC2 peptide *had* no effect on AngII/AT1 receptor activation of [ERK] . Positive_regulation EPHB2 SLC33A1 24095877 2867692 In vitro , Ang II suppressed RECK expression in adult mouse cardiac fibroblasts ( CF ) via dependent [ERK/Sp1] *activation* , but induced MMPs 2 , 14 and 9 via NF-?B , AP-1 and/or Sp1 activation . Positive_regulation EPHB2 SLC33A1 9806232 544756 Moreover we observed that receptor stimulation *activated* extracellular signal regulated kinase ( [ERK] ) , whereas the AT2 receptor stimulation inhibited the activation of ERK . Positive_regulation EPHB2 SLC9A1 14600156 1187509 Inhibition of with pharmacological agents or by isotonic replacement of sodium in the perfusate with choline or tetramethylammonium greatly *attenuated* [ERK] activation by 5-HT or Ang II . Positive_regulation EPHB2 SLC9A1 14600156 1187526 Receptor independent activation of NHE-1 by acute acid loading of RASM cells resulted in the rapid phosphorylation of [ERK] , which could be *blocked* by pharmacological inhibitors of or by isotonic replacement of sodium , closely linking the proton transport function of NHE-1 to ERK activation . Positive_regulation EPHB2 SLC9A1 17167226 1662036 Additionally , inhibition of *resulted* in [ERK] inhibition as well . Positive_regulation EPHB2 SLC9A3R2 15115658 1241538 In contrast , the *dependent* increase of [ERK] phosphorylation was not affected by pretreatment with PD98059 in Rat1/NHERF2 cells . Positive_regulation EPHB2 SLC9A3R2 15115658 1241540 Thus , the *dependent* increase of [ERK] phosphorylation occurs in a MEK independent fashion . Positive_regulation EPHB2 SLC9A3R2 15115658 1241542 Pretreatment with PP2 , a specific inhibitor of Src family tyrosine kinase , completely blocked the *dependent* increase of the phosphorylation of [ERK] and Akt , suggesting that NHERF2 up-regulates Erk phosphorylation through a Src family kinase dependent pathway . Positive_regulation EPHB2 SLC9A3R2 15143197 1247483 In addition , *increases* LPA induced [ERK] activation , which is followed by cyclooxygenase-2 induction via a PLC dependent pathway . Positive_regulation EPHB2 SLCO6A1 10509564 650907 Moreover , both GST-Tat2E and also *stimulated* [ERK/MAPK] . Positive_regulation EPHB2 SLCO6A1 11409852 826366 In bovine aortic endothelial cells , and the 165 amino acid VEGF isoform ( VEGF165 ) *induce* transient [ERK] ( 1/2 ) phosphorylation with similar potency and kinetics . Positive_regulation EPHB2 SLCO6A1 11409852 826371 Accordingly , *induces* [ERK] ( 1/2 ) phosphorylation in KDR transfected porcine aortic endothelial cells but not in parental cells . Positive_regulation EPHB2 SLCO6A1 22609943 2609766 , which maintains Cdk1 activity , *caused* [ERK] activity in the eggs to persist for over 120 min after fertilization , and prolonged [ Ca ( 2+ ) ] ( i ) oscillations . Positive_regulation EPHB2 SLPI 12402303 1009480 Tyrphostin AG1478 , an EGFR tyrosine kinase inhibitor , blocks *induced* [MAPK/ERK] activation but not EGFR internalization . Positive_regulation EPHB2 SMAD1 20362069 2266562 Furthermore , we detected that blocking of the SDF-1 signaling inhibited the BMP2 induced early expression of Runt related factor-2 ( Runx2 ) and osterix ( Osx ) , two `` master '' regulators of osteogenesis , and the SDF-1 effect was mediated via intracellular and [Erk] *activation* . Positive_regulation EPHB2 SMAD2 20362069 2266563 Furthermore , we detected that blocking of the SDF-1 signaling inhibited the BMP2 induced early expression of Runt related factor-2 ( Runx2 ) and osterix ( Osx ) , two `` master '' regulators of osteogenesis , and the SDF-1 effect was mediated via intracellular and [Erk] *activation* . Positive_regulation EPHB2 SMAD3 20362069 2266564 Furthermore , we detected that blocking of the SDF-1 signaling inhibited the BMP2 induced early expression of Runt related factor-2 ( Runx2 ) and osterix ( Osx ) , two `` master '' regulators of osteogenesis , and the SDF-1 effect was mediated via intracellular and [Erk] *activation* . Positive_regulation EPHB2 SMAD3 22521802 2630874 Overexpression of the signaling protein Smad3 enhanced TGF-ß induced activation of ERK MAPK , whereas inhibition of with a siRNA *blocked* [ERK] MAPK phosphorylation in response to TGF-ß . Positive_regulation EPHB2 SMAD4 20362069 2266565 Furthermore , we detected that blocking of the SDF-1 signaling inhibited the BMP2 induced early expression of Runt related factor-2 ( Runx2 ) and osterix ( Osx ) , two `` master '' regulators of osteogenesis , and the SDF-1 effect was mediated via intracellular and [Erk] *activation* . Positive_regulation EPHB2 SMAD5 20362069 2266566 Furthermore , we detected that blocking of the SDF-1 signaling inhibited the BMP2 induced early expression of Runt related factor-2 ( Runx2 ) and osterix ( Osx ) , two `` master '' regulators of osteogenesis , and the SDF-1 effect was mediated via intracellular and [Erk] *activation* . Positive_regulation EPHB2 SMAD6 20362069 2266567 Furthermore , we detected that blocking of the SDF-1 signaling inhibited the BMP2 induced early expression of Runt related factor-2 ( Runx2 ) and osterix ( Osx ) , two `` master '' regulators of osteogenesis , and the SDF-1 effect was mediated via intracellular and [Erk] *activation* . Positive_regulation EPHB2 SMAD7 17096210 1685767 overexpression of *increased* this TGF-beta1 mediated phosphorylation of the [ERK] ; Positive_regulation EPHB2 SMAD7 20362069 2266568 Furthermore , we detected that blocking of the SDF-1 signaling inhibited the BMP2 induced early expression of Runt related factor-2 ( Runx2 ) and osterix ( Osx ) , two `` master '' regulators of osteogenesis , and the SDF-1 effect was mediated via intracellular and [Erk] *activation* . Positive_regulation EPHB2 SMAD9 20362069 2266569 Furthermore , we detected that blocking of the SDF-1 signaling inhibited the BMP2 induced early expression of Runt related factor-2 ( Runx2 ) and osterix ( Osx ) , two `` master '' regulators of osteogenesis , and the SDF-1 effect was mediated via intracellular and [Erk] *activation* . Positive_regulation EPHB2 SMN1 22116522 2591726 In the mean time , reducing Erbin expression enhanced [ERK] phosphorylation , promoted the E-cadherin suppression , and *induced* expression and fibronection secretion in response to TGF-ß1 , which could be rescued if cells were treated with the inhibitor of MEK1/2 U0126 . Positive_regulation EPHB2 SMO 14647422 1210464 In transient transfection experiments , we demonstrate that IFNalpha inhibits [Erk] phosphorylation and serum response element activation *induced* by expression of , Gli1 , PDGFRalpha and activated Raf , but not activated mitogen activated Erk regulating kinase ( Mek ) , suggesting that IFNalpha targets mainly on Mek function . Positive_regulation EPHB2 SNAP25 14656708 1218719 A Western blotting study showed that significantly *enhanced* phosphorylation of [ERK] , which was reversed by MPG . Positive_regulation EPHB2 SNAP25 16547595 1568173 However , treatment with U0126 completely blocked *induced* [ERK] activation and markedly , although not completely , inhibited the cardioprotection exerted by SNAP . Positive_regulation EPHB2 SNCA 12885576 1116712 We propose that elevated expression of *causes* changes in cell cycle regulators through [ERK] activation leading to apoptosis of postmitotic neurons . Positive_regulation EPHB2 SNCG 17016652 1630011 In our previous studies , we showed that overexpression *activates* [ERK] . Positive_regulation EPHB2 SOAT1 12955078 1137679 Further biochemical analyses revealed that IL-3 *induced* , [Erk] , and PI3 kinase pathways in SHP-2 ( -/- ) cells were impaired and reintroduction of WT SHP-2 into mutant cells partially restored IL-3 signaling . Positive_regulation EPHB2 SOAT1 17363567 1713058 Leptin induced phosphorylation of [ERK] and AKT was *dependent* on Janus activated kinase <(JAK)/STAT> activation . Positive_regulation EPHB2 SOCS1 16122907 1507323 By contrast , JAB1-knock-down by siRNA revealed that minimum levels were *necessary* for transient activation of [ERK] by MIF . Positive_regulation EPHB2 SOCS1 21764457 2472228 Overexpression of *reduced* G-CSF generation and phosphorylation of [ERK] , JNK , and p38 MAPK in gAd treated cells . Positive_regulation EPHB2 SOCS6 17210122 1688988 In addition , we demonstrated that PMA , insulin , and PDGF increased both the stability of endogenous expressed and [Erk] *activation* in MDA-MB231 cells . Positive_regulation EPHB2 SOD1 10471390 641780 However , *enhanced* the silica induced [ERK] phosphorylation , indicating a role for H ( 2 ) O ( 2 ) in ERK activation . Positive_regulation EPHB2 SOD2 10471390 641781 However , *enhanced* the silica induced [ERK] phosphorylation , indicating a role for H ( 2 ) O ( 2 ) in ERK activation . Positive_regulation EPHB2 SOD3 10471390 641782 However , *enhanced* the silica induced [ERK] phosphorylation , indicating a role for H ( 2 ) O ( 2 ) in ERK activation . Positive_regulation EPHB2 SORT1 20813449 2341770 During differentiation , a sustained [Erk] phosphorylation in *response* to was observed , cells began to exit from the cell cycle and exhibit increased neurite-like extensions . Positive_regulation EPHB2 SORT1 22061968 2547662 Rac1b regulates *stimulated* [Mek-Erk] signaling , directing marrow isolated adult multilineage inducible ( MIAMI ) cells toward an early neuronal phenotype . Positive_regulation EPHB2 SOS1 10330169 614171 The paradigm for *activation* of Ras and extracellular signal regulated kinase ( [ERK] ) /mitogen activated protein (MAP) kinase by extracellular stimuli via tyrosine kinases , Shc , Grb2 , and does not encompass an obvious role for phosphoinositide (PI) 3-kinase , and yet inhibitors of this lipid kinase family have been shown to block the ERK/MAP kinase signalling pathway under certain circumstances . Positive_regulation EPHB2 SOS1 10976990 729630 In contrast to their implication in epidermal growth factor (EGF) receptor tyrosine kinase signaling , the adaptor protein Shc , the complex , and the small G protein Ras were not *involved* in the activation of [Erk] induced by either LPA or PGF2alpha in MC3T3-E1 cells , suggesting that activation of Erk by Gi and Gq protein coupled receptors is Ras independent in these cells . Positive_regulation EPHB2 SOS1 11791173 901779 Here we determined the efficacy of Shc and N-Shc toward Erk activation in NGF treated PC12 cells , and found that N-Shc transduced dependent [Erk] *activation* less efficiently than Shc . Positive_regulation EPHB2 SOS1 12629518 1067425 EGF dependent GTP/GDP exchange activity for Ras was suppressed in the Gab1-/- cells and expression of a constitutively active *restored* [ERK] activation in these cells , indicating that Gab1 functions upstream of Ras . Positive_regulation EPHB2 SOS1 24497027 2933189 *regulates* sustained TCR mediated [Erk] activation . Positive_regulation EPHB2 SOS2 10330169 614172 The paradigm for *activation* of Ras and extracellular signal regulated kinase ( [ERK] ) /mitogen activated protein (MAP) kinase by extracellular stimuli via tyrosine kinases , Shc , Grb2 , and does not encompass an obvious role for phosphoinositide (PI) 3-kinase , and yet inhibitors of this lipid kinase family have been shown to block the ERK/MAP kinase signalling pathway under certain circumstances . Positive_regulation EPHB2 SOS2 10976990 729631 In contrast to their implication in epidermal growth factor (EGF) receptor tyrosine kinase signaling , the adaptor protein Shc , the complex , and the small G protein Ras were not *involved* in the activation of [Erk] induced by either LPA or PGF2alpha in MC3T3-E1 cells , suggesting that activation of Erk by Gi and Gq protein coupled receptors is Ras independent in these cells . Positive_regulation EPHB2 SOS2 11791173 901780 Here we determined the efficacy of Shc and N-Shc toward Erk activation in NGF treated PC12 cells , and found that N-Shc transduced *dependent* [Erk] activation less efficiently than Shc . Positive_regulation EPHB2 SOS2 12629518 1067426 EGF dependent GTP/GDP exchange activity for Ras was suppressed in the Gab1-/- cells and expression of a constitutively active *restored* [ERK] activation in these cells , indicating that Gab1 functions upstream of Ras . Positive_regulation EPHB2 SOX18 23391722 2748219 Expression of mutant RAF1 ( S259A ) in ECs activated [ERK] and *induced* and PROX1 expression , leading to increased commitment of venous ECs to the lymphatic fate . Positive_regulation EPHB2 SOX2 24188385 2890259 Co-culture with CM resulted in an increased resistance to Adriamycin and enhanced expressions of a-FP , MMP9 , ABCG2 , CD133 , and , as well as the *activation* of [ERK] , AKT , WNT , and TGF-ß1 pathways . Positive_regulation EPHB2 SOX9 20457810 2275639 We also show that fibronectin is required for the Pref-1 mediated inhibition of adipocyte differentiation , the *activation* of [ERK/MAPK] , and the upregulation of . Positive_regulation EPHB2 SPAG11B 12933667 1132616 Activation of receptor *induced* phosphorylation of [ERK] and cAMP response element binding protein ( CREB ) . Positive_regulation EPHB2 SPHK1 14742298 1242751 S1P activated Akt and ERK within minutes , and inhibition of *blocked* RSV induced [ERK] and Akt activation , leading to accelerated cell death after viral infection . Positive_regulation EPHB2 SPHK1 15210766 1262026 Blocking acid ceramidase but not activity in alveolar macrophages *led* to decreased [ERK] and Akt activity and induction of cell death . Positive_regulation EPHB2 SPHK1 19932089 2198065 Dihydrotestosterone ( DHT ) triggered cell growth in steroid deprived MC3T3 cells , which was associated with a rapid stimulation of and *activation* of both Akt and [ERK] signaling pathways . Positive_regulation EPHB2 SPHK1 21848514 2510099 However , inhibition did *diminish* EGF ( epidermal growth factor ) -driven increases in S1P levels and Akt ( also known as protein kinase B ) [/ERK] ( extracellular-signal regulated kinase ) phosphorylation . Positive_regulation EPHB2 SPHK2 14742298 1242753 S1P activated Akt and [ERK] within minutes , and inhibition of *blocked* RSV induced ERK and Akt activation , leading to accelerated cell death after viral infection . Positive_regulation EPHB2 SPHK2 15210766 1262027 Blocking acid ceramidase but not activity in alveolar macrophages *led* to decreased [ERK] and Akt activity and induction of cell death . Positive_regulation EPHB2 SPP1 20817864 2325086 HUVEC treatment with ICOS-Fc did not modulate expression of adhesion molecules and cytokines , but it substantially downmodulated [ERK] phosphorylation *induced* by E-selectin triggering or , which may influence HUVEC adhesiveness . Positive_regulation EPHB2 SPRED1 15465815 1342179 negatively *regulates* interleukin-3 mediated [ERK/mitogen] activated protein (MAP) kinase activation in hematopoietic cells . Positive_regulation EPHB2 SPRED1 15465815 1342220 In IL-3 dependent Ba/F3 cells expressing c-kit , forced expression of *resulted* in a reduced proliferation rate and [ERK] activation in response to not only SCF but also IL-3 . Positive_regulation EPHB2 SPRED1 15465815 1342222 In contrast , DeltaC *augmented* IL-3 induced cell proliferation and [ERK] activation . Positive_regulation EPHB2 SPRED1 17438136 1742797 In cultured cells , the overexpression of or Spred-2 strongly *suppressed* vascular endothelial growth factor-C ( VEGF-C ) /VEGF receptor (VEGFR)-3 mediated [ERK] activation , while Spred-1/2-deficient cells were extremely sensitive to VEGFR-3 signaling . Positive_regulation EPHB2 SPRED2 15465815 1342221 In contrast , DeltaC *augmented* IL-3 induced cell proliferation and [ERK] activation . Positive_regulation EPHB2 SPRED2 17438136 1742796 In cultured cells , the overexpression of Spred-1 or strongly *suppressed* vascular endothelial growth factor-C ( VEGF-C ) /VEGF receptor (VEGFR)-3 mediated [ERK] activation , while Spred-1/2-deficient cells were extremely sensitive to VEGFR-3 signaling . Positive_regulation EPHB2 SPRED2 18799725 1986901 AKT and [ERK] *activation* and inhibition of were detected in HSCs from aged FoxO3a-deficient mice . Positive_regulation EPHB2 SPRED2 22305891 2575881 Mutation of three tyrosines 303/343/353 within the SPR domain not only abolish EGF induced p85 binding to Spred2 but also attenuate the inhibitory effect on [Ras/ERK] *activation* by . Positive_regulation EPHB2 SPRED3 15465815 1342223 In contrast , DeltaC *augmented* IL-3 induced cell proliferation and [ERK] activation . Positive_regulation EPHB2 SPRY1 18582454 1946693 In addition , overexpression of *resulted* in sustained [ERK] activation and increased expression of p21 and STAT1 . Positive_regulation EPHB2 SPRY2 18048363 1852463 In the parental , non-H-Ras transformed fibroblasts , expression of *resulted* in the inhibition of H-Ras and [ERK] activation , suggesting that the positive effect of Spry2 in tumor formation is specific to H-Ras transformation . Positive_regulation EPHB2 SPRY2 18427547 1951494 In addition , the ectopic overexpression of in HT cells drastically *reduced* the activation of [ERK] upon phorbol 12-myristate-13-acetate stimulation . Positive_regulation EPHB2 SPRY4 14977631 1250870 The expression of , an intracellular FGF receptor antagonist , shows a temporally and spatially restricted pattern in embryonic lung and is *induced* by [ERK] signaling . Positive_regulation EPHB2 SPSB1 15713673 1395916 also *enhanced* HGF induced [Erk] phosphorylation . Positive_regulation EPHB2 SRC 10675331 667819 In contrast , *activated* by isoproterenol led to tyrosine phosphorylation of Shc and subsequent [Erk] activation , but not tyrosine phosphorylation of cortactin or Stat3 . Positive_regulation EPHB2 SRC 10777553 686850 The family kinase inhibitor , PP2 ( 20 nM-20 microM ) *attenuated* CCh stimulated EGFR and [ERK] phosphorylation and potentiated chloride secretory responses to CCh . Positive_regulation EPHB2 SRC 11013230 752641 We previously showed that is *required* for [ERK] activation by beta ( 2 ) AR and that it is recruited to activated beta ( 2 ) AR through binding of the Src homology 3 (SH3) domain to proline-rich regions of the adapter protein beta-arrestin1 . Positive_regulation EPHB2 SRC 11100733 755932 The G betagamma-responsive [ERK] activation induced by H2O2 is independent of ligands binding to Gi-coupled receptors , but *requires* phosphatidylinositol-3-kinase and activation . Positive_regulation EPHB2 SRC 11821947 908913 To investigate the specific role of A-Raf in this process we generated A-Raf deficient mouse embryonic fibroblasts ( MEFs ) and embryonic stem ( ES ) cells by gene targeting and characterized their ability to undergo proliferation , differentiation , apoptosis , [ERK] *activation* , and transformation by oncogenic Ras and . Positive_regulation EPHB2 SRC 11914123 984255 The kinase inhibitors PP1 and PP2 partially *diminished* the [ERK] responses elicited by both norepinephrine and PGF2alpha . Positive_regulation EPHB2 SRC 12221082 998298 Furthermore , a mutant ( SrcS17D ) , which mimics PKA phosphorylation at serine 17 , *stimulates* Rap1 activation , Rap1/B-Raf association , and [ERK] activation but does not stimulate Ras or AKT . Positive_regulation EPHB2 SRC 12437585 1016201 Further , inhibition of non-receptor tyrosine kinase activity by PP1 *attenuated* the [ERK] response generated by both receptor subtypes , but only mGlu1a receptor-ERK activation was attenuated by PDGF receptor tyrosine kinase inhibitor AG1296 . Positive_regulation EPHB2 SRC 12456636 1021305 FRNK expression disrupted the formation of a v-Src-FAK signaling complex , inhibited p130Cas tyrosine phosphorylation , and attenuated *stimulated* [ERK] and JNK kinase activation . Positive_regulation EPHB2 SRC 12493768 1056679 Consistent with this premise , FSH stimulated [ERK] activation is *inhibited* by the cell-permeable protein kinase A-specific inhibitor peptide Myr-PKI as well as by inhibitors of MEK , , a Ca ( 2+ ) channel blocker , and chelation of extracellular Ca ( 2+ ) . Positive_regulation EPHB2 SRC 12538624 1050196 Surprisingly , although is *involved* in GnRH-A stimulated [ERK] , its involvement is mapped to another region ( -280/-180 ) containing the glycoprotein-specific element . Positive_regulation EPHB2 SRC 14637190 1171424 Consistent with the abrogation of Src activity was the reduction of Src-Tyr-416 phosphorylation , mediated Shc-Tyr-317 phosphorylation , decreased [ERK] *activation* , and cell proliferation in v-Src transformed cells . Positive_regulation EPHB2 SRC 14741371 1203257 Biochemical analysis revealed that the Cas SH3 domain selectively inhibited *stimulated* activations of AKT and JNK , but not [ERK] and STAT3 . Positive_regulation EPHB2 SRC 14982949 1250912 We found that inhibitor PP2 and Syk inhibitor piceatannol *inhibited* phagocytosis , macrophage-inflammatory protein-1alpha ( MIP-1alpha ) release , as well as phosphorylation of [extracellular regulated kinase (ERK)] and Akt , consistent with Src/Syk involvement early in FcgammaR signaling . Positive_regulation EPHB2 SRC 15381832 1298782 The gastric mucosal phospholipid secretory responses to isoproterenol , furthermore , were inhibited by PP2 , a selective inhibitor of tyrosine kinase responsible for ligand independent EGFR phosphorylation , but not by [ERK] *inhibitor* , PD98059 . Positive_regulation EPHB2 SRC 15385614 1300138 Ionotropic and metabotropic receptors , protein kinase A , protein kinase C , and *contribute* to C-fiber induced [ERK] activation and cAMP response element binding protein phosphorylation in dorsal horn neurons , leading to central sensitization . Positive_regulation EPHB2 SRC 15504454 1327470 [ERK] activation by arsenite was fully dependent on the catalytic activity of the epidermal growth factor (EGF) receptor and partially *dependent* on kinase activity . Positive_regulation EPHB2 SRC 15689414 1402587 The stimulatory effects of isoproterenol and cAMP on ERK phosphorylation were not reduced by the PKA inhibitor H-89 , whereas the family inhibitor 4-amino-5- ( 4-chlorophenyl ) -7- ( t-butyl ) pyrazolo [ 3,4-d ] pyrimidase ( PP2 ) and transfection of a dominant negative Src construct *diminished* isoproterenol induced [ERK] activation . Positive_regulation EPHB2 SRC 15826932 1394203 activation also *leads* to activation of [ERK] and p38 MAPKs . Positive_regulation EPHB2 SRC 15845549 1418604 Down-regulation of endogenously expressed CNK1 by small inhibitory RNA interferes with *dependent* activation of [ERK] . Positive_regulation EPHB2 SRC 15919658 1433647 VEGF induced [Erk] activation was not dependent on phosphoinositide (PI) 3-kinase activation but *required* sequential phosphorylation of type 2 VEGF receptor , PLCgamma and , as demonstrated by inhibitors SU1498 , U73122 , and PP1 , respectively . Positive_regulation EPHB2 SRC 15985706 1429022 The gastric mucin secretory responses to isoproterenol , furthermore , were inhibited by PP2 , a selective inhibitor of tyrosine kinase responsible for ligand independent EGFR autophosphorylation , but not by [ERK] *inhibitor* , PD98059 . Positive_regulation EPHB2 SRC 16122907 1507319 A role for an upstream Src kinase was proven by applying Src-deficient cells which did not exhibit transient [ERK] activation upon treatment with MIF , but in which MIF induced ERK signalling could be *restored* by re-expressing . Positive_regulation EPHB2 SRC 16214133 1468838 In addition , transfection of ES cells with DN-Src , or DN-Ras partially inhibited 8-Br-cAMP induced ERK1/2 and consequently PLD activation , whereas cotransfection of DN-Src and DN-Ras completely inhibited ERK1/2 and PLD activation , suggesting that and Ras independently *regulate* [ERK/PLD] activation . Positive_regulation EPHB2 SRC 16214133 1468894 Taken together , these results demonstrate a novel pathway in ES cells that 8-Br-cAMP activate PLD through PKA and ERK1/2 and this [ERK/PLD] activation by 8-Br-cAMP is *mediated* by and Ras , separately . Positive_regulation EPHB2 SRC 16436051 1516311 This interaction required the intact binding motifs of the Grb2 SH2 domain , and a mutant ( Dok-3-FF ) having a Tyr/Phe substitution at these motifs failed to inhibit Ras and [Erk] *activation* downstream of a cytoplasmic PTK . Positive_regulation EPHB2 SRC 16809338 1606022 Arrestin is essential to recruit Src to this process , as alpha(2A)AR mediated [ERK] signaling in Arr2 ,3-/- MEFs does not *involve* . Positive_regulation EPHB2 SRC 16844778 1592161 Hsp90 inhibition transiently activates Src kinase and promotes *dependent* Akt and [Erk] activation . Positive_regulation EPHB2 SRC 16888778 1672675 Thus , focal signaling *contributes* to [ERK] activation and promotes contraction in late pregnancy . Positive_regulation EPHB2 SRC 16973240 1646991 H2O2 and dependent transactivation of the EGF receptor *mediates* the stimulatory effect of leptin on renal [ERK] and Na+ , K+-ATPase . Positive_regulation EPHB2 SRC 17088251 1675906 We investigated whether and Rac1 mediate deformation *induced* FAK and [ERK] phosphorylation and proliferation in human Caco-2 and rat IEC-6 intestinal epithelial cells . Positive_regulation EPHB2 SRC 17106250 1663651 In contrast , inhibition of or metalloproteinases *caused* distinct effects on [ERK] activation by E2 and tamoxifen . Positive_regulation EPHB2 SRC 17222183 1689174 We explored the underlying molecular mechanisms and found that blockage of E-cadherin by Decma elicits a signaling pathway downstream of E-cadherin that leads to *dependent* Shc and [extracellular regulated kinase (Erk)] activation and results in uPAgene activation . Positive_regulation EPHB2 SRC 17267111 1697006 therefore , *mediates* CgA induced [ERK] phosphorylation leading to iNOS expression and NO production . Positive_regulation EPHB2 SRC 17372305 1713806 inhibitors PP1 and PP2 *blocked* [ERK] and p38 activation by low but not high EGF , and only high EGF increased Shc phosphorylation . Positive_regulation EPHB2 SRC 18067607 1874488 Phosphorylated FAK and *activated* [Erk] and induced actin stress fibre formation . Positive_regulation EPHB2 SRC 18340408 1892122 Our findings demonstrate that leptin protection of salivary gland acinar cells against ethanol cytotoxicity involves kinase *mediated* parallel activation of [MAPK/ERK] and Akt that result in up-regulation of the respective prostaglandin and nitric oxide synthase pathways . Positive_regulation EPHB2 SRC 18442977 1921085 Inhibition of the signaling *blocked* 5-HT(2A/C) activation of [ERK] and the counteractive effect of 5-HT(2A/C) on 5-HT(1A) regulation of NMDAR currents . Positive_regulation EPHB2 SRC 18448311 1908333 Surprisingly , even in the absence of EGF addition , expression *induced* activation of EGFR and of EGFR mediated downstream signaling targets [ERK] and Shc . Positive_regulation EPHB2 SRC 18719212 1955804 Taken together , these results indicate that , at least in human gingival fibroblasts , EMD induced [ERK] activation and proliferation are partially *due* to a dependent , metalloproteinase mediated transactivation of EGFR . Positive_regulation EPHB2 SRC 19602257 2112081 Our previous data indicates that can *increase* [ERK] activity through Raf kinase in response to ischemic stimuli . Positive_regulation EPHB2 SRC 19602257 2112096 *induces* up-regulation of [ERK] activity and its target transcription factors , CREB and ERalpha , through attenuation of PP2A activity . Positive_regulation EPHB2 SRC 19713443 2168162 FGF-1 induced phosphorylation of Src , and phosphorylation of MEK , [ERK] and Ark was *inhibited* by inhibitors in rat astrocytes . Positive_regulation EPHB2 SRC 19778233 2141049 The induction of TNF-alpha and TGF-beta1 by silica was suppressed by inhibitor ( PP1 ) , [ERK] *inhibitor* ( PD98059 ) , but not by p38 kinase inhibitor ( SB203580 ) . Positive_regulation EPHB2 SRC 20431342 2268082 WITHDRAWN : zVAD induced autophagic cell death requires *dependent* [ERK] and JNK activation and reactive oxygen species generation . Positive_regulation EPHB2 SRC 20431342 2268083 Notably , our data also indicated the involvement of *dependent* JNK and [ERK] in zVAD induced autophagic cell death . Positive_regulation EPHB2 SRC 20483033 2367789 In the present study , we examined the *role* of in regulating the inhibition of [p-ERK] in the brain following RACK1 over-expression during morphine reward . Positive_regulation EPHB2 SRC 21127402 2372511 zVAD induced autophagic cell death requires *dependent* [ERK] and JNK activation and reactive oxygen species generation . Positive_regulation EPHB2 SRC 21127402 2372512 Notably , our data also indicated the involvement of *dependent* JNK and [ERK] in zVAD induced ROS production and autophagic death . Positive_regulation EPHB2 SRC 21127402 2372684 In conclusion , we confirm the autophagic death in zVAD treated L929 cells , and define a new molecular pathway in which *dependent* [ERK] and JNK activation can link a signal from caspase inhibition to autophagy , which in turn induce ROS production and PARP activation , eventually leading to necroptosis . Positive_regulation EPHB2 SRC 21486283 2489437 The CB(1) receptor ligand anandamide caused a Ga ( i/o ) -dependent inhibition of adenylate cyclase reducing intracellular cAMP levels , and Ga ( i/o ) , phosphoinositide-3-kinase , *dependent* [ERK] activation . Positive_regulation EPHB2 SRC 21954875 2546913 In addition , the tyrosine kinase inhibitor , PP2 , *blocked* ISO mediated both Akt and [ERK] activation and heavily suppressed viability . Positive_regulation EPHB2 SRC 22592532 2614453 Serum , fibronectin , ( Y527 ) and Ras ( V12 ) *activated* CaMKII and [ERK] , at different extents . Positive_regulation EPHB2 SRC 22931352 2697629 The activation of PKCd by daidzein was attenuated in the *presence* of a kinase inhibitor , and that of [ERK] by daidzein was diminished in the presence of either a Src or PKCd inhibitor . Positive_regulation EPHB2 SRC 23221422 2711116 Inhibition of or Raf-1 *blocked* LPS induced [ERK] activation . Positive_regulation EPHB2 SRSF1 23843040 2854328 [B-Raf-MEK-ERK] *activation* by contributes to transformation as pharmacological inhibition of MEK1 inhibits SRSF1 mediated transformation . Positive_regulation EPHB2 SST 10347203 616819 Mitogen activated protein/ERK kinase-1 inhibition also decreased the time interval over which *induced* [ERK] phosphorylation was observed ( < 2 h ) . Positive_regulation EPHB2 SST 10446204 636417 In contrast , the *induced* phosphorylation of [ERK] obtained at 4 h , although sensitive to both pertussis toxin and transducin , was unaffected by PP1 but ablated by PD 98059 . Positive_regulation EPHB2 SST 11088001 764955 However , in these cells , robustly activates the MAP kinase and *augments* bFGF induced stimulation of [ERK] . Positive_regulation EPHB2 SST 19910453 2189293 In sst2A expressing HEK293 cells , inhibited cAMP production , stimulated intracellular calcium accumulation , and *increased* [ERK] phosphorylation . Positive_regulation EPHB2 SST 19910453 2189294 However , although *increased* intracellular calcium and [ERK] phosphorylation , SOM230 and KE108 again antagonized these effects . Positive_regulation EPHB2 SSTR1 11088001 764957 We show that the *activation* of [ERK] via is mediated by the betagamma subunit of a pertussis toxin-sensitive G-protein and requires both the small G protein Ras and the serine/threonine kinase Raf-1 . Positive_regulation EPHB2 SSTR1 9892010 586555 We show that the *activation* of [ERK] via is pertussis toxin sensitive and requires the small G protein Ras , phosphatidylinositol 3-kinase , the serine/threonine kinase Raf-1 , and the protein tyrosine phosphatase SHP-2 . Positive_regulation EPHB2 SSTR1 9892010 586578 The *activation* of [ERK] by increased the expression of the cyclin dependent protein kinase inhibitor p21 ( cip1/WAF1 ) . Positive_regulation EPHB2 ST13 20512919 2270636 also *increases* [extracellular regulated kinase (ERK)] phosphorylation levels , but the change is due to adenovirus replication . Positive_regulation EPHB2 STAB2 24586357 2920170 Hyaluronic acid receptor *regulates* [Erk] phosphorylation and arterial -- venous differentiation in zebrafish . Positive_regulation EPHB2 STAT1 22634008 2614832 Moreover , sorafenib inhibited IFN-a induced oncogenic signaling of STAT3 , AKT and [ERK] but not the *activation* of the tumor suppressor . Positive_regulation EPHB2 STAT3 16788692 1599456 Our data suggest a *role* of tyrosine phosphorylated in the suppression of [ERK] activation . Positive_regulation EPHB2 STAT5A 12819209 1120870 This was accompanied by a ligand induced increase in protein kinase B and [Erk] *activation* but not that of . Positive_regulation EPHB2 STAU1 16266318 1478811 In addition , IGF-1 elicited a mild but sustained activation of extracellular signal regulated kinase ( [ERK] ) 1/2 in human VSMC that was abolished after 1 h in the *presence* of . Positive_regulation EPHB2 STIP1 17498662 1744464 Both hyperosmolarity induced by sucrose and monodansyl-cadaverine blocked [Erk] activity *induced* by , without affecting the high basal Akt activity typical of A172 . Positive_regulation EPHB2 STIP1 20501939 2307729 Functionally , recombinant significantly *induced* [ERK] phosphorylation , promoted DNA synthesis , and increased Ki-67 immunoreactivity in ovarian cancer cells , suggesting that STIP1 in vitro promotes cell proliferation . Positive_regulation EPHB2 SULT1E1 10744637 680619 The *induced* increase in [phospho-ERK] was suppressed by NO donors and the cGMP mimetic , and reversed by cGMP-PKG inhibitor , as was expression of AML1B and DNA binding in nuclear extracts . Positive_regulation EPHB2 SYK 10415002 631130 A direct serine phosphorylation and *activation* of by [ERK] was observed in in vitro experiments . Positive_regulation EPHB2 SYK 17458858 1743178 *dependent* [ERK] activation regulates IL-2 and IL-10 production by DC stimulated with zymosan . Positive_regulation EPHB2 SYK 19296913 2064038 However , phosphorylation at YY525/526 was shown to significantly increase the enzymatic activity of and to be *required* for sustained PLCgamma2 , Akt and [ERK] signaling as well as B-cell transformation . Positive_regulation EPHB2 SYK 24569586 2924754 An EBV infection in HCECs can lead to a mesenchymal fibroblast-like morphology , and cause EMT through the *activation* of PI3K/Akt and [Erk] by TGF-ß1 mediated and Src signaling . Positive_regulation EPHB2 SYK 9720763 528540 We report that inhibition of PI3K by wortmannin or an inhibitory p85 construct , p85deltaiSH2 , reduced the TCR induced *dependent* activation of Erk2 , as well as the appearance of [phospho-Erk] and phospho-Mek . Positive_regulation EPHB2 SYNCRIP 19304659 2073385 Mechanism of sustained *activation* of ribosomal S6 kinase ( RSK ) and [ERK] by kaposi sarcoma associated herpesvirus ORF45 : complexes retain active phosphorylated ERK AND RSK and protect them from dephosphorylation . Positive_regulation EPHB2 SYNCRIP 19319189 2052414 GTP-Raf-MEK-ERK to *promote* sustained [ERK] activation and regulate H-Ras dependent neuritogenesis . Positive_regulation EPHB2 TAC1 18995179 1990066 Febuxostat blunted the *induced* increases in nitrotyrosine ( indicating reduced myocardial oxidative stress ) , [p-Erk] ( Thr202/Tyr204 ) , and p-mTOR ( Ser2488 ) , with no effect on total Erk or total mTOR . Positive_regulation EPHB2 TAC1 20926779 2347562 Interestingly , T3 administration dramatically canceled *induced* [ERK] phosphorylation ( 36 % lower compared with control ) . Positive_regulation EPHB2 TAC3 18995179 1990067 Febuxostat blunted the *induced* increases in nitrotyrosine ( indicating reduced myocardial oxidative stress ) , [p-Erk] ( Thr202/Tyr204 ) , and p-mTOR ( Ser2488 ) , with no effect on total Erk or total mTOR . Positive_regulation EPHB2 TAC3 20926779 2347563 Interestingly , T3 administration dramatically canceled *induced* [ERK] phosphorylation ( 36 % lower compared with control ) . Positive_regulation EPHB2 TAC4 18995179 1990068 Febuxostat blunted the *induced* increases in nitrotyrosine ( indicating reduced myocardial oxidative stress ) , [p-Erk] ( Thr202/Tyr204 ) , and p-mTOR ( Ser2488 ) , with no effect on total Erk or total mTOR . Positive_regulation EPHB2 TAC4 20926779 2347564 Interestingly , T3 administration dramatically canceled *induced* [ERK] phosphorylation ( 36 % lower compared with control ) . Positive_regulation EPHB2 TACC2 16616457 1569029 PKA not only signals to directly phosphorylate transcription factors like cAMP response element binding protein and to promote by phosphorylating histone H3 , this versatile kinase also *enhances* the activity of the p38 MAPK , [ERK] , and PI3K pathways . Positive_regulation EPHB2 TACC3 16616457 1569030 PKA not only signals to directly phosphorylate transcription factors like cAMP response element binding protein and to promote by phosphorylating histone H3 , this versatile kinase also *enhances* the activity of the p38 MAPK , [ERK] , and PI3K pathways . Positive_regulation EPHB2 TANK 16291755 1510582 However , neither RIP1 nor overexpression was *sufficient* to activate Tpl2 and [ERK] . Positive_regulation EPHB2 TANK 22711886 2621438 Moreover , consistent with previous results , we also show that was *required* for efficient JNK and [ERK] activation in response to CD40 engagement . Positive_regulation EPHB2 TAOK2 11279118 811814 Previous studies demonstrated that in vitro the protein kinase *activates* [MAP/ERK kinases (MEKs)] 3 , 4 , and 6 toward their substrates p38 MAP kinase and c-Jun N-terminal kinase/stress activated protein kinase ( JNK/SAPK ) . Positive_regulation EPHB2 TAP1 20230813 2244152 Reducing expression by RNA interference *increased* [Ras/ERK] signaling in multiple cell types . Positive_regulation EPHB2 TAP2 22883599 2692274 stimulation *triggered* the phosphorylation of mitogen activated protein kinases JNK , p38 , and [ERK] , as well as the nuclear translocation of NF-?B , which all played essential roles in activating TNF-a expression . Positive_regulation EPHB2 TAT 10509564 650906 Moreover , both GST-Tat2E and also *stimulated* [ERK/MAPK] . Positive_regulation EPHB2 TAT 11409852 826365 In bovine aortic endothelial cells , and the 165 amino acid VEGF isoform ( VEGF165 ) *induce* transient [ERK] ( 1/2 ) phosphorylation with similar potency and kinetics . Positive_regulation EPHB2 TAT 11409852 826367 The synthetic peptide ( 41-60 ) , but not peptides Tat ( 1-21 ) and Tat ( 71-86 ) , *causes* [ERK] ( 1/2 ) phosphorylation , thus implicating Tat/KDR interaction in the activation of this signalling pathway . Positive_regulation EPHB2 TAT 11409852 826370 Accordingly , *induces* [ERK] ( 1/2 ) phosphorylation in KDR transfected porcine aortic endothelial cells but not in parental cells . Positive_regulation EPHB2 TAT 16436505 1540499 Here , we report that ligation on human endothelial cells *results* in the activation of the small GTPases Ras and Rac and the mitogen activated protein kinase [ERK] , specifically through its RGD region . Positive_regulation EPHB2 TAT 16436505 1540510 In addition , we demonstrated that activation of Ras , but not of Rac , *induces* [ERK] phosphorylation . Positive_regulation EPHB2 TAT 17940286 1835531 Instead , knock down of the novel oxidase Nox4 completely suppressed *dependent* Ras and [ERK] activation downstream of Rac1 and RhoA . Positive_regulation EPHB2 TAT 20211724 2243352 *caused* an increase in inositol phosphate formation , calcium mobilization , [ERK] activation and degranulation of mast cells . Positive_regulation EPHB2 TAZ 24125755 2889229 FGF2 stimulates osteogenic differentiation through [ERK] *induced* expression . Positive_regulation EPHB2 TBCA 11784793 901088 *induced* [phospho-ERK] primarily colocalized with prodynorphin and NK-1 in superficial dorsal horn neurons . Positive_regulation EPHB2 TBCA 15207334 1261464 This *induced* increase in [ERK] phosphorylation was mediated through trk receptors , because intrathecal treatment with the tyrosine kinase inhibitor , K252a , reduced the activation of ERK . Positive_regulation EPHB2 TBCA 19368817 2058758 Formalin- , and saline-injections *induced* an increase in [p-ERK-IR] in the LC . Positive_regulation EPHB2 TBCA 20722971 2335623 *induced* [ERK] activation in ipsilateral dorsal horn neurons declined after 2 days . Positive_regulation EPHB2 TBCA 21687934 2455557 *induced* phosphorylation of the [ERK] was inhibited by both dizocilpine and EA , but that of p38 was inhibited by EA only . Positive_regulation EPHB2 TBCA 24498195 2913869 *induced* [p-ERK] primarily colocalized with p-Cdk5 ( S159 ) in superficial dorsal horn neurons . Positive_regulation EPHB2 TCF12 15089040 1237826 Several reports indicate that the activation of extracellular signal regulated kinase ( [ERK] ) *induces* microphthalmia associated ( MITF ) degradation . Positive_regulation EPHB2 TCF12 16298938 1484892 In vitro exposure to FGF-20 increased expression of the Nrf2 and oxygen radical scavenging enzymes such as MnSOD , *activated* signal transduction pathways ( [ERK] and Akt ) and resulted in increased survival of irradiated cells in vitro . Positive_regulation EPHB2 TCF12 17117479 1677445 Finally , we show that activated [ERK] *induced* increased expression of the Egr-1 , which then bound to the promoter region of p35 . Positive_regulation EPHB2 TCF12 19248765 2050881 We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a [MEK/ERK] independent *activation* of signaling . Positive_regulation EPHB2 TCF12 21771752 2509897 HHE mediated accumulation of ROS may *induce* redox-sensitive , NF-?B , through activation of [ERK] and JNK , resulting in cellular apoptosis in HK-2 cells . Positive_regulation EPHB2 TCF12 24085800 2902620 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of [ERK] and *activation* of Ets-1 . Positive_regulation EPHB2 TCF12 24337644 2895137 Additionally , 15d-PGJ ( 2 ) inhibited the phosphorylation of the extracellular signal regulated kinase ( [ERK] ) and the *activation* of nuclear ( NF-?B ) . Positive_regulation EPHB2 TCF15 15089040 1237827 Several reports indicate that the activation of extracellular signal regulated kinase ( [ERK] ) *induces* microphthalmia associated ( MITF ) degradation . Positive_regulation EPHB2 TCF15 16298938 1484893 In vitro exposure to FGF-20 increased expression of the Nrf2 and oxygen radical scavenging enzymes such as MnSOD , *activated* signal transduction pathways ( [ERK] and Akt ) and resulted in increased survival of irradiated cells in vitro . Positive_regulation EPHB2 TCF15 17117479 1677446 Finally , we show that activated [ERK] *induced* increased expression of the Egr-1 , which then bound to the promoter region of p35 . Positive_regulation EPHB2 TCF15 19248765 2050882 We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a [MEK/ERK] independent *activation* of signaling . Positive_regulation EPHB2 TCF15 21771752 2509898 HHE mediated accumulation of ROS may *induce* redox-sensitive , NF-?B , through activation of [ERK] and JNK , resulting in cellular apoptosis in HK-2 cells . Positive_regulation EPHB2 TCF15 24085800 2902621 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of [ERK] and *activation* of Ets-1 . Positive_regulation EPHB2 TCF15 24337644 2895138 Additionally , 15d-PGJ ( 2 ) inhibited the phosphorylation of the extracellular signal regulated kinase ( [ERK] ) and the *activation* of nuclear ( NF-?B ) . Positive_regulation EPHB2 TCF19 15089040 1237828 Several reports indicate that the activation of extracellular signal regulated kinase ( [ERK] ) *induces* microphthalmia associated ( MITF ) degradation . Positive_regulation EPHB2 TCF19 16298938 1484894 In vitro exposure to FGF-20 increased expression of the Nrf2 and oxygen radical scavenging enzymes such as MnSOD , *activated* signal transduction pathways ( [ERK] and Akt ) and resulted in increased survival of irradiated cells in vitro . Positive_regulation EPHB2 TCF19 17117479 1677447 Finally , we show that activated [ERK] *induced* increased expression of the Egr-1 , which then bound to the promoter region of p35 . Positive_regulation EPHB2 TCF19 19248765 2050883 We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a [MEK/ERK] independent *activation* of signaling . Positive_regulation EPHB2 TCF19 21771752 2509899 HHE mediated accumulation of ROS may *induce* redox-sensitive , NF-?B , through activation of [ERK] and JNK , resulting in cellular apoptosis in HK-2 cells . Positive_regulation EPHB2 TCF19 24085800 2902622 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of [ERK] and *activation* of Ets-1 . Positive_regulation EPHB2 TCF19 24337644 2895139 Additionally , 15d-PGJ ( 2 ) inhibited the phosphorylation of the extracellular signal regulated kinase ( [ERK] ) and the *activation* of nuclear ( NF-?B ) . Positive_regulation EPHB2 TCF20 15089040 1237829 Several reports indicate that the activation of extracellular signal regulated kinase ( [ERK] ) *induces* microphthalmia associated ( MITF ) degradation . Positive_regulation EPHB2 TCF20 16298938 1484895 In vitro exposure to FGF-20 increased expression of the Nrf2 and oxygen radical scavenging enzymes such as MnSOD , *activated* signal transduction pathways ( [ERK] and Akt ) and resulted in increased survival of irradiated cells in vitro . Positive_regulation EPHB2 TCF20 17117479 1677448 Finally , we show that activated [ERK] *induced* increased expression of the Egr-1 , which then bound to the promoter region of p35 . Positive_regulation EPHB2 TCF20 19248765 2050884 We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a [MEK/ERK] independent *activation* of signaling . Positive_regulation EPHB2 TCF20 21771752 2509900 HHE mediated accumulation of ROS may *induce* redox-sensitive , NF-?B , through activation of [ERK] and JNK , resulting in cellular apoptosis in HK-2 cells . Positive_regulation EPHB2 TCF20 24085800 2902623 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of [ERK] and *activation* of Ets-1 . Positive_regulation EPHB2 TCF20 24337644 2895140 Additionally , 15d-PGJ ( 2 ) inhibited the phosphorylation of the extracellular signal regulated kinase ( [ERK] ) and the *activation* of nuclear ( NF-?B ) . Positive_regulation EPHB2 TCF21 15089040 1237830 Several reports indicate that the activation of extracellular signal regulated kinase ( [ERK] ) *induces* microphthalmia associated ( MITF ) degradation . Positive_regulation EPHB2 TCF21 16298938 1484896 In vitro exposure to FGF-20 increased expression of the Nrf2 and oxygen radical scavenging enzymes such as MnSOD , *activated* signal transduction pathways ( [ERK] and Akt ) and resulted in increased survival of irradiated cells in vitro . Positive_regulation EPHB2 TCF21 17117479 1677449 Finally , we show that activated [ERK] *induced* increased expression of the Egr-1 , which then bound to the promoter region of p35 . Positive_regulation EPHB2 TCF21 19248765 2050885 We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a [MEK/ERK] independent *activation* of signaling . Positive_regulation EPHB2 TCF21 21771752 2509901 HHE mediated accumulation of ROS may *induce* redox-sensitive , NF-?B , through activation of [ERK] and JNK , resulting in cellular apoptosis in HK-2 cells . Positive_regulation EPHB2 TCF21 24085800 2902624 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of [ERK] and *activation* of Ets-1 . Positive_regulation EPHB2 TCF21 24337644 2895141 Additionally , 15d-PGJ ( 2 ) inhibited the phosphorylation of the extracellular signal regulated kinase ( [ERK] ) and the *activation* of nuclear ( NF-?B ) . Positive_regulation EPHB2 TCF23 15089040 1237834 Several reports indicate that the activation of extracellular signal regulated kinase ( [ERK] ) *induces* microphthalmia associated ( MITF ) degradation . Positive_regulation EPHB2 TCF23 16298938 1484900 In vitro exposure to FGF-20 increased expression of the Nrf2 and oxygen radical scavenging enzymes such as MnSOD , *activated* signal transduction pathways ( [ERK] and Akt ) and resulted in increased survival of irradiated cells in vitro . Positive_regulation EPHB2 TCF23 17117479 1677453 Finally , we show that activated [ERK] *induced* increased expression of the Egr-1 , which then bound to the promoter region of p35 . Positive_regulation EPHB2 TCF23 19248765 2050889 We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a [MEK/ERK] independent *activation* of signaling . Positive_regulation EPHB2 TCF23 21771752 2509905 HHE mediated accumulation of ROS may *induce* redox-sensitive , NF-?B , through activation of [ERK] and JNK , resulting in cellular apoptosis in HK-2 cells . Positive_regulation EPHB2 TCF23 24085800 2902628 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of [ERK] and *activation* of Ets-1 . Positive_regulation EPHB2 TCF23 24337644 2895145 Additionally , 15d-PGJ ( 2 ) inhibited the phosphorylation of the extracellular signal regulated kinase ( [ERK] ) and the *activation* of nuclear ( NF-?B ) . Positive_regulation EPHB2 TCF24 15089040 1237836 Several reports indicate that the activation of extracellular signal regulated kinase ( [ERK] ) *induces* microphthalmia associated ( MITF ) degradation . Positive_regulation EPHB2 TCF24 16298938 1484902 In vitro exposure to FGF-20 increased expression of the Nrf2 and oxygen radical scavenging enzymes such as MnSOD , *activated* signal transduction pathways ( [ERK] and Akt ) and resulted in increased survival of irradiated cells in vitro . Positive_regulation EPHB2 TCF24 17117479 1677455 Finally , we show that activated [ERK] *induced* increased expression of the Egr-1 , which then bound to the promoter region of p35 . Positive_regulation EPHB2 TCF24 19248765 2050891 We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a [MEK/ERK] independent *activation* of signaling . Positive_regulation EPHB2 TCF24 21771752 2509907 HHE mediated accumulation of ROS may *induce* redox-sensitive , NF-?B , through activation of [ERK] and JNK , resulting in cellular apoptosis in HK-2 cells . Positive_regulation EPHB2 TCF24 24085800 2902630 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of [ERK] and *activation* of Ets-1 . Positive_regulation EPHB2 TCF24 24337644 2895147 Additionally , 15d-PGJ ( 2 ) inhibited the phosphorylation of the extracellular signal regulated kinase ( [ERK] ) and the *activation* of nuclear ( NF-?B ) . Positive_regulation EPHB2 TCF25 15089040 1237835 Several reports indicate that the activation of extracellular signal regulated kinase ( [ERK] ) *induces* microphthalmia associated ( MITF ) degradation . Positive_regulation EPHB2 TCF25 16298938 1484901 In vitro exposure to FGF-20 increased expression of the Nrf2 and oxygen radical scavenging enzymes such as MnSOD , *activated* signal transduction pathways ( [ERK] and Akt ) and resulted in increased survival of irradiated cells in vitro . Positive_regulation EPHB2 TCF25 17117479 1677454 Finally , we show that activated [ERK] *induced* increased expression of the Egr-1 , which then bound to the promoter region of p35 . Positive_regulation EPHB2 TCF25 19248765 2050890 We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a [MEK/ERK] independent *activation* of signaling . Positive_regulation EPHB2 TCF25 21771752 2509906 HHE mediated accumulation of ROS may *induce* redox-sensitive , NF-?B , through activation of [ERK] and JNK , resulting in cellular apoptosis in HK-2 cells . Positive_regulation EPHB2 TCF25 24085800 2902629 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of [ERK] and *activation* of Ets-1 . Positive_regulation EPHB2 TCF25 24337644 2895146 Additionally , 15d-PGJ ( 2 ) inhibited the phosphorylation of the extracellular signal regulated kinase ( [ERK] ) and the *activation* of nuclear ( NF-?B ) . Positive_regulation EPHB2 TCF3 15089040 1237831 Several reports indicate that the activation of extracellular signal regulated kinase ( [ERK] ) *induces* microphthalmia associated ( MITF ) degradation . Positive_regulation EPHB2 TCF3 16298938 1484897 In vitro exposure to FGF-20 increased expression of the Nrf2 and oxygen radical scavenging enzymes such as MnSOD , *activated* signal transduction pathways ( [ERK] and Akt ) and resulted in increased survival of irradiated cells in vitro . Positive_regulation EPHB2 TCF3 17117479 1677450 Finally , we show that activated [ERK] *induced* increased expression of the Egr-1 , which then bound to the promoter region of p35 . Positive_regulation EPHB2 TCF3 19248765 2050886 We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a [MEK/ERK] independent *activation* of signaling . Positive_regulation EPHB2 TCF3 21771752 2509902 HHE mediated accumulation of ROS may *induce* redox-sensitive , NF-?B , through activation of [ERK] and JNK , resulting in cellular apoptosis in HK-2 cells . Positive_regulation EPHB2 TCF3 24085800 2902625 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of [ERK] and *activation* of Ets-1 . Positive_regulation EPHB2 TCF3 24337644 2895142 Additionally , 15d-PGJ ( 2 ) inhibited the phosphorylation of the extracellular signal regulated kinase ( [ERK] ) and the *activation* of nuclear ( NF-?B ) . Positive_regulation EPHB2 TCF4 15089040 1237832 Several reports indicate that the activation of extracellular signal regulated kinase ( [ERK] ) *induces* microphthalmia associated ( MITF ) degradation . Positive_regulation EPHB2 TCF4 16298938 1484898 In vitro exposure to FGF-20 increased expression of the Nrf2 and oxygen radical scavenging enzymes such as MnSOD , *activated* signal transduction pathways ( [ERK] and Akt ) and resulted in increased survival of irradiated cells in vitro . Positive_regulation EPHB2 TCF4 17117479 1677451 Finally , we show that activated [ERK] *induced* increased expression of the Egr-1 , which then bound to the promoter region of p35 . Positive_regulation EPHB2 TCF4 19248765 2050887 We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a [MEK/ERK] independent *activation* of signaling . Positive_regulation EPHB2 TCF4 21771752 2509903 HHE mediated accumulation of ROS may *induce* redox-sensitive , NF-?B , through activation of [ERK] and JNK , resulting in cellular apoptosis in HK-2 cells . Positive_regulation EPHB2 TCF4 24085800 2902626 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of [ERK] and *activation* of Ets-1 . Positive_regulation EPHB2 TCF4 24337644 2895143 Additionally , 15d-PGJ ( 2 ) inhibited the phosphorylation of the extracellular signal regulated kinase ( [ERK] ) and the *activation* of nuclear ( NF-?B ) . Positive_regulation EPHB2 TCF7 15089040 1237833 Several reports indicate that the activation of extracellular signal regulated kinase ( [ERK] ) *induces* microphthalmia associated ( MITF ) degradation . Positive_regulation EPHB2 TCF7 16298938 1484899 In vitro exposure to FGF-20 increased expression of the Nrf2 and oxygen radical scavenging enzymes such as MnSOD , *activated* signal transduction pathways ( [ERK] and Akt ) and resulted in increased survival of irradiated cells in vitro . Positive_regulation EPHB2 TCF7 17117479 1677452 Finally , we show that activated [ERK] *induced* increased expression of the Egr-1 , which then bound to the promoter region of p35 . Positive_regulation EPHB2 TCF7 19248765 2050888 We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a [MEK/ERK] independent *activation* of signaling . Positive_regulation EPHB2 TCF7 21771752 2509904 HHE mediated accumulation of ROS may *induce* redox-sensitive , NF-?B , through activation of [ERK] and JNK , resulting in cellular apoptosis in HK-2 cells . Positive_regulation EPHB2 TCF7 24085800 2902627 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of [ERK] and *activation* of Ets-1 . Positive_regulation EPHB2 TCF7 24337644 2895144 Additionally , 15d-PGJ ( 2 ) inhibited the phosphorylation of the extracellular signal regulated kinase ( [ERK] ) and the *activation* of nuclear ( NF-?B ) . Positive_regulation EPHB2 TERF1 11956184 953629 cAMP stimulated Ras independent and *dependent* [ERK] phosphorylation and cell proliferation in B-Raf expressing cells , but inhibited growth in B-Raf lacking cells . Positive_regulation EPHB2 TERF1 12402047 1009419 We conclude that cAMP induced regulation of [ERK] and *activation* of are independent processes . Positive_regulation EPHB2 TERF1 15167895 1259138 ARMS is rapidly tyrosine phosphorylated after binding of neurotrophins to Trk receptors and provides a docking site for the CrkL-C3G complex , resulting in *dependent* sustained [ERK] activation . Positive_regulation EPHB2 TERF1 15723799 1376768 Ras independent activation of [ERK] signaling via the torso receptor tyrosine kinase is *mediated* by . Positive_regulation EPHB2 TERF1 20877310 2381752 Moreover , we found that negatively *regulated* GNDF induced [ERK] activation and neurite outgrowth . Positive_regulation EPHB2 TERF1 24523415 2924177 Moreover , our results showed that NMDA mediated activation of the small G-protein Ras is necessary for PI3K/Akt pathway activation , whereas was *involved* in NMDA phosphorylation of [ERK] . Positive_regulation EPHB2 TERF2 11146560 760886 We provide evidence that mutants *promote* [ERK] activation and that the active protein induces a more sustained activation than the inactive protein . Positive_regulation EPHB2 TERF2 11228165 788431 is *involved* in cell stretching modulation of p38 but not [ERK] or JNK MAP kinase . Positive_regulation EPHB2 TERF2 11479306 860638 Moreover , inhibition of by a Rap1 GTPase activating protein-1 also *resulted* in a decrease in [ERK] and Akt phosphorylation , which was not further decreased by cAMP , suggesting that cAMP inhibits ERK and Akt by inhibiting Rap1 . Positive_regulation EPHB2 TERF2 11479306 860694 The *role* of in [ERK] and Akt activity was further demonstrated by our observation that an active form of Epac , which activated Rap1 in the absence of cAMP , increased ERK and Akt phosphorylation . Positive_regulation EPHB2 TERF2 11956184 953630 cAMP stimulated Ras independent and *dependent* [ERK] phosphorylation and cell proliferation in B-Raf expressing cells , but inhibited growth in B-Raf lacking cells . Positive_regulation EPHB2 TERF2 12402047 1009420 We conclude that cAMP induced regulation of [ERK] and *activation* of are independent processes . Positive_regulation EPHB2 TERF2 14551200 1175537 Experiments involving the expression of the dominant negative mutants of Ras and Rap1 signaling ( RasN17 or Rap1N17 ) indicate that both GTPases Ras and Rap1 are recruited for the ERK activation by VIP and PACAP38 , whereas is poorly *involved* in TRH or EGF induced [ERK] activation . Positive_regulation EPHB2 TERF2 14607972 1162182 Functionally , either interferes with Ras mediated ERK activation or *activates* [ERK] independently of Ras in a cell-context dependent manner . Positive_regulation EPHB2 TERF2 15167895 1259139 ARMS is rapidly tyrosine phosphorylated after binding of neurotrophins to Trk receptors and provides a docking site for the CrkL-C3G complex , resulting in *dependent* sustained [ERK] activation . Positive_regulation EPHB2 TERF2 15723799 1376769 Ras independent activation of [ERK] signaling via the torso receptor tyrosine kinase is *mediated* by . Positive_regulation EPHB2 TERF2 16507992 1529677 We confirm that the PKA independent activation of by Epac1 activates a perinuclear pool of Rap1 and that this does not *result* in [ERK] activation . Positive_regulation EPHB2 TERF2 17472964 1750444 Moreover , Ca2+ induced *activation* of [ERK] through and expression of loricrin were reduced in primary cultured nectin-1-/- keratinocytes ; Positive_regulation EPHB2 TERF2 20877310 2381753 Moreover , we found that negatively *regulated* GNDF induced [ERK] activation and neurite outgrowth . Positive_regulation EPHB2 TERF2 24523415 2924178 Moreover , our results showed that NMDA mediated activation of the small G-protein Ras is necessary for PI3K/Akt pathway activation , whereas was *involved* in NMDA phosphorylation of [ERK] . Positive_regulation EPHB2 TERF2IP 11146560 760888 We provide evidence that mutants *promote* [ERK] activation and that the active protein induces a more sustained activation than the inactive protein . Positive_regulation EPHB2 TERF2IP 11228165 788433 is *involved* in cell stretching modulation of p38 but not [ERK] or JNK MAP kinase . Positive_regulation EPHB2 TERF2IP 11479306 860640 Moreover , inhibition of by a Rap1 GTPase activating protein-1 also *resulted* in a decrease in [ERK] and Akt phosphorylation , which was not further decreased by cAMP , suggesting that cAMP inhibits ERK and Akt by inhibiting Rap1 . Positive_regulation EPHB2 TERF2IP 11479306 860696 The *role* of in [ERK] and Akt activity was further demonstrated by our observation that an active form of Epac , which activated Rap1 in the absence of cAMP , increased ERK and Akt phosphorylation . Positive_regulation EPHB2 TERF2IP 11956184 953633 cAMP stimulated Ras independent and *dependent* [ERK] phosphorylation and cell proliferation in B-Raf expressing cells , but inhibited growth in B-Raf lacking cells . Positive_regulation EPHB2 TERF2IP 12402047 1009423 We conclude that cAMP induced regulation of [ERK] and *activation* of are independent processes . Positive_regulation EPHB2 TERF2IP 14551200 1175540 Experiments involving the expression of the dominant negative mutants of Ras and Rap1 signaling ( RasN17 or Rap1N17 ) indicate that both GTPases Ras and Rap1 are recruited for the ERK activation by VIP and PACAP38 , whereas is poorly *involved* in TRH or EGF induced [ERK] activation . Positive_regulation EPHB2 TERF2IP 14607972 1162184 Functionally , either interferes with Ras mediated ERK activation or *activates* [ERK] independently of Ras in a cell-context dependent manner . Positive_regulation EPHB2 TERF2IP 15167895 1259142 ARMS is rapidly tyrosine phosphorylated after binding of neurotrophins to Trk receptors and provides a docking site for the CrkL-C3G complex , resulting in *dependent* sustained [ERK] activation . Positive_regulation EPHB2 TERF2IP 15723799 1376772 Ras independent activation of [ERK] signaling via the torso receptor tyrosine kinase is *mediated* by . Positive_regulation EPHB2 TERF2IP 16507992 1529680 We confirm that the PKA independent activation of by Epac1 activates a perinuclear pool of Rap1 and that this does not *result* in [ERK] activation . Positive_regulation EPHB2 TERF2IP 17472964 1750447 Moreover , Ca2+ induced *activation* of [ERK] through and expression of loricrin were reduced in primary cultured nectin-1-/- keratinocytes ; Positive_regulation EPHB2 TERF2IP 20877310 2381756 Moreover , we found that negatively *regulated* GNDF induced [ERK] activation and neurite outgrowth . Positive_regulation EPHB2 TERF2IP 24523415 2924181 Moreover , our results showed that NMDA mediated activation of the small G-protein Ras is necessary for PI3K/Akt pathway activation , whereas was *involved* in NMDA phosphorylation of [ERK] . Positive_regulation EPHB2 TFR2 20634490 2334908 We showed that the silencing of HFE and *reduced* both [Erk] phosphorylation and furin expression , that the exogenous expression of the two enhanced the induction of phosphoErk1/2 and furin by holotransferrin , but that this did not occur when the pathogenic HFE mutant C282Y was expressed . Positive_regulation EPHB2 TGFA 19823173 2187237 Rho/ROCK and [MEK/ERK] *activation* by induces articular cartilage degradation . Positive_regulation EPHB2 TGFA 9419349 480891 ITF also decreased activation of [ERK] activity *induced* by either , which links extracellular stimuli to the Ras/Raf/MEK/ERK pathway via the epidermal growth factor receptor , or phorbol 12-myristate 13-acetate , which activates Raf through protein kinase C. ITF induced inhibition of ERK activity was blocked by an inhibitor of tyrosine and dual-specific phosphatases , sodium orthovanadate . Positive_regulation EPHB2 TGFB1 10455028 638396 *had* no inhibitory effect on [ERK] activation induced by PDGF-BB or bFGF . Positive_regulation EPHB2 TGFB1 10580747 570114 *induced* a rapid activation of extracellular signal regulated kinase ( [ERK] ) with a peak at 5 min , which decreased to basal levels within 240 min after TGF-beta1 stimulation . Positive_regulation EPHB2 TGFB1 10580747 570115 [ERK] *activation* by was also confirmed by in vivo phosphorylation assays of Elk1 . Positive_regulation EPHB2 TGFB1 10862759 722255 Dependence of ERK/AP-1 activation on bFGF induction was demonstrated by inhibition of *induced* [ERK/AP-1] activation when conditioned medium from TGF-beta1 treated cells was incubated with bFGF neutralizing antibody . Positive_regulation EPHB2 TGFB1 10962574 727219 *activates* [Ras/Erk] signalling activity in both cell lines . Positive_regulation EPHB2 TGFB1 12163544 972601 The acute effects of on K ( Ca ) channels are mediated by posttranslational events and *require* activation of the MAP kinase [Erk] . Positive_regulation EPHB2 TGFB1 12415008 1011235 alpha8beta1 binding to *increased* cell proliferation and phosphorylation of FAK and [ERK] , but did not activate of TGFbeta1 . Positive_regulation EPHB2 TGFB1 12760970 1091439 *activated* c-Jun NH2-terminal kinase (JNK) and p38 MAP kinase , but not [ERK] in HFL-1 cells . Positive_regulation EPHB2 TGFB1 15069087 1265684 In MLK3 overexpressing cells , [ERK] , JNKs , and p38 MAP kinases were further activated in *response* to compared with the control cells . Positive_regulation EPHB2 TGFB1 15147727 1247931 These results suggest that the ERK pathway may be involved in the melanogenic signaling cascade , and that delayed [ERK] *activation* by contributes to reduced melanin synthesis via MITF down-regulation . Positive_regulation EPHB2 TGFB1 15389548 1304763 Like NFLC , induction of urokinase plasminogen activator (uPAR) , transin/matrix metalloproteinase 3 (MMP3) , Fra-1 and ( TGF beta 1 ) *required* collaborative [ERK] and JNK signaling while the increased expression of cortexin , rat collapsin response mediator protein 4 ( rCRMP4 ) , rat growth and transformation dependent protein ( RGT ) , and synapsin II required neither mitogen activated protein kinase (MAPK) pathway . Positive_regulation EPHB2 TGFB1 15677311 1376072 Antioxidants effectively inhibited *induced* cellular ROS , phosphorylation of Smad 2 , p38 MAPK , and [ERK] , and EMT . Positive_regulation EPHB2 TGFB1 15979845 1497978 [ERK] *activation* by was significantly attenuated by treatment with N-acetyl-l-cysteine or catalase , indicating that reactive oxygen species ( ROS ) generated by TGF-beta1 , mainly H2O2 , stimulates ERK signaling pathway to induce the p21WAF1/Cip1 expression . Positive_regulation EPHB2 TGFB1 16105451 1444884 ( 3 ) The inhibitors SB203580 and PD98059 suppressed *induced* p38 kinase and [Erk] phosphorylation respectively . Positive_regulation EPHB2 TGFB1 17096210 1685753 Here , we explore the role of TGF-beta/Smads signaling compounds in TGF-beta1 mediated activation of extracellular signal regulated kinase ( ERK ) MAPK in human papillomavirus ( HPV ) -18 immortalized human bronchial epithelial cell line BEP2D and the role of *induced* phosphorylation of [ERK] in proliferation and apoptosis of BEP2D . Positive_regulation EPHB2 TGFB1 17096210 1685766 overexpression of Smad7 increased this *mediated* phosphorylation of the [ERK] ; Positive_regulation EPHB2 TGFB1 17096210 1685769 These data revealed that TbetaRII and Smad7 play the critical roles in *mediated* activation of [ERK] ; Positive_regulation EPHB2 TGFB1 17096210 1685772 and *induced* phosphorylation of [ERK] may participate in BEP2D cell proliferation and apoptosis regulation . Positive_regulation EPHB2 TGFB1 17418380 1748723 [ERK] phosphorylation was *increased* by IL-13 and . Positive_regulation EPHB2 TGFB1 17540773 1767319 The interaction of endoglin with beta-arrestin2 regulates mediated [ERK] *activation* and migration in endothelial cells . Positive_regulation EPHB2 TGFB1 18057187 1861391 In this study , we aimed to determine whether the sevoflurane mediated phosphorylation of [ERK] and Akt , induction of HSP70 , and reduction in NF-kappaB activation are *due* to receptor mediated signaling after PS externalization in HK-2 cells . Positive_regulation EPHB2 TGFB1 18082740 1971430 Treatment with rosiglitazone , a PPARgamma agonist , reversed the TGF-beta1 effect by antagonizing the activation of [ERK] and Smad that was *induced* by . Positive_regulation EPHB2 TGFB1 18669633 1967391 FRNK overexpression blocks *induced* [ERK] or p38 MAPK activation in the presence , and surprisingly , in the absence of FAK . Positive_regulation EPHB2 TGFB1 18936144 2021494 *increased* the phosphorylation of [ERK] and Smad3 . Positive_regulation EPHB2 TGFB1 19343212 2057359 Specifically , [MEK-ERK] signaling was dose-dependently induced in *response* to in immortalized cells in vitro and in the A. stephensi midgut epithelium in vivo . Positive_regulation EPHB2 TGFB1 20553909 2290046 Our results show , for the first time , that TSA inhibits *induced* [ERK] activation and overrides pro-apoptotic signals like Smad3 and p38 in human RPTECs . Positive_regulation EPHB2 TGFB1 22764581 2623426 Furthermore , AKF-PD significantly blocked *induced* phosphorylation of [ERK] . Positive_regulation EPHB2 TGFB1 8663331 368521 Mitogen activated protein (MAP) kinase phosphatase-1 and a dominant negative [MAP/ERK] kinase 1 mutant reduced *stimulation* of plasminogen activator inhibitor-1 ( PAI-1 ) promoter activity by from 11.5- to 4-fold and 4.9-fold , respectively . Positive_regulation EPHB2 TGFB2 15223827 1264846 Both [ERK] and p38 MAPK pathways were also *activated* by . Positive_regulation EPHB2 TGFB2 16795080 1578999 These results indicate that *induced* activation of [Erk-MAPK] is an important signaling component that stimulates cell proliferation to enrich osteoprogenitor cells , thereby promoting their differentiation into osteoblasts to achieve a rapid calvarial bone expansion . Positive_regulation EPHB2 TGFB2 17540773 1767320 The interaction of endoglin with beta-arrestin2 regulates mediated [ERK] *activation* and migration in endothelial cells . Positive_regulation EPHB2 TGFB3 17540773 1767321 The interaction of endoglin with beta-arrestin2 regulates mediated [ERK] *activation* and migration in endothelial cells . Positive_regulation EPHB2 TGFBI 16672769 1558699 *triggered* phosphorylation and activation of AKT , [ERK] , focal adhesion kinase , and paxillin mediating the adhesion and migration of VSMCs . Positive_regulation EPHB2 TGFBR1 15843168 1398346 Inhibition of the TGF beta type I receptor slightly *reduced* phosphorylation of [ERK] in MCF-7 cells , but neither inhibited phosphorylation of ERK in MDA-MB-468 cells nor TGF beta1 induced migration of both cell lines . Positive_regulation EPHB2 TGFBR1 17072348 1716597 Induction of MMP-9 by signaling *requires* [MEK-ERK] but not JNK , p38 MAPK or Smad4 . Positive_regulation EPHB2 TGFBR1 20147383 2208289 Loss of mediated signaling also stimulated Pten gene expression and *inhibited* [ERK] phosphorylation in vivo . Positive_regulation EPHB2 THBS1 10490955 645822 The phosphorylation of [ERK] in the *presence* of full-length was transient and dependent on a beta 1 integrin receptor . Positive_regulation EPHB2 THBS1 18571589 1930065 To evaluate the effect of G proteins on *induced* [ERK] or p38 activation , preincubated VSMCs were exposed to serum-free medium or TSP-1 and analyzed by Western immunoblotting . Positive_regulation EPHB2 THBS1 18571589 1930067 The cAMP stimulators forskolin and IBMX abolished *induced* chemotaxis and [ERK] and p38 activation . Positive_regulation EPHB2 THPO 11446731 835415 Requirement of induced *activation* of [ERK] for megakaryocyte differentiation and of p38 for erythroid differentiation . Positive_regulation EPHB2 TIAM1 18349077 1892318 Indeed , deficiency or the inhibition of intracellular ROS production *blocks* [ERK] phosphorylation and sensitizes wild-type keratinocytes to apoptotic stimuli . Positive_regulation EPHB2 TIE1 12890486 1117269 Localization of and phospholipase D in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Positive_regulation EPHB2 TIE1 18425120 1907996 Furthermore , activated at cell-cell or cell-substratum contacts *leads* to preferential activation of Akt and [Erk] , respectively . Positive_regulation EPHB2 TIMP2 19551841 2185580 binding with cellular MT1-MMP *stimulates* invasion promoting [MEK/ERK] signaling in cancer cells . Positive_regulation EPHB2 TIMP2 19551841 2185590 The *induced* stimulation of [ERK] signaling in cancer cells explains the direct , as opposed to the inverse , association of TIMP-2 expression with poor prognosis in cancer . Positive_regulation EPHB2 TIMP3 18157585 1918904 treatment *induced* p38 and [ERK] phosphorylation . Positive_regulation EPHB2 TINF2 11956184 953631 cAMP stimulated Ras independent and *dependent* [ERK] phosphorylation and cell proliferation in B-Raf expressing cells , but inhibited growth in B-Raf lacking cells . Positive_regulation EPHB2 TINF2 12402047 1009421 We conclude that cAMP induced regulation of [ERK] and *activation* of are independent processes . Positive_regulation EPHB2 TINF2 15167895 1259140 ARMS is rapidly tyrosine phosphorylated after binding of neurotrophins to Trk receptors and provides a docking site for the CrkL-C3G complex , resulting in *dependent* sustained [ERK] activation . Positive_regulation EPHB2 TINF2 15723799 1376770 Ras independent activation of [ERK] signaling via the torso receptor tyrosine kinase is *mediated* by . Positive_regulation EPHB2 TINF2 20877310 2381754 Moreover , we found that negatively *regulated* GNDF induced [ERK] activation and neurite outgrowth . Positive_regulation EPHB2 TINF2 24523415 2924179 Moreover , our results showed that NMDA mediated activation of the small G-protein Ras is necessary for PI3K/Akt pathway activation , whereas was *involved* in NMDA phosphorylation of [ERK] . Positive_regulation EPHB2 TIRAP 22634720 2675862 Furthermore , we demonstrated that *dependent* [p38/ERK] activation is critical to TLR2 mediated T-cell IFN-? release following EtOH and burn injury . Positive_regulation EPHB2 TJP1 22782886 2645337 *regulates* [Erk] , Smad1/5/8 , Smad2 , and RhoA activities to modulate self-renewal and differentiation of mouse embryonic stem cells . Positive_regulation EPHB2 TLR1 16484370 1534806 Despite rescuing *dependent* [ERK] activation in nfkb1 ( -/- ) bone marrow derived macrophages by using an estrogen receptor regulated version of the mitogen activated protein 3 kinase , c-Raf ( Raf : ER ) , CpG or LPS induction of IL-10 was only partially restored in nfkb1 ( -/- ) cells expressing Raf : ER , a finding consistent with NF-kappaB1 regulating IL-10 by a combination of ERK independent and -dependent mechanisms . Positive_regulation EPHB2 TLR1 18355244 1957956 ISO-1 is a promising parent molecule which inhibits *induced* [ERK] activation and inflammatory cytokine production in monocytes , whose role may be complicated by cell-type specificity . Positive_regulation EPHB2 TLR1 24737107 2943020 mediated STAT3 and [ERK] *activation* controls IL-10 secretion by human B cells . Positive_regulation EPHB2 TLR10 16484370 1534814 Despite rescuing dependent [ERK] *activation* in nfkb1 ( -/- ) bone marrow derived macrophages by using an estrogen receptor regulated version of the mitogen activated protein 3 kinase , c-Raf ( Raf : ER ) , CpG or LPS induction of IL-10 was only partially restored in nfkb1 ( -/- ) cells expressing Raf : ER , a finding consistent with NF-kappaB1 regulating IL-10 by a combination of ERK independent and -dependent mechanisms . Positive_regulation EPHB2 TLR10 18355244 1957964 ISO-1 is a promising parent molecule which inhibits *induced* [ERK] activation and inflammatory cytokine production in monocytes , whose role may be complicated by cell-type specificity . Positive_regulation EPHB2 TLR10 24737107 2943028 mediated STAT3 and [ERK] *activation* controls IL-10 secretion by human B cells . Positive_regulation EPHB2 TLR2 16484370 1534807 Despite rescuing dependent [ERK] *activation* in nfkb1 ( -/- ) bone marrow derived macrophages by using an estrogen receptor regulated version of the mitogen activated protein 3 kinase , c-Raf ( Raf : ER ) , CpG or LPS induction of IL-10 was only partially restored in nfkb1 ( -/- ) cells expressing Raf : ER , a finding consistent with NF-kappaB1 regulating IL-10 by a combination of ERK independent and -dependent mechanisms . Positive_regulation EPHB2 TLR2 17312106 1699617 The *induced* weak activation of p38 , but not [ERK] or cytokine mRNA . Positive_regulation EPHB2 TLR2 18355244 1957957 ISO-1 is a promising parent molecule which inhibits *induced* [ERK] activation and inflammatory cytokine production in monocytes , whose role may be complicated by cell-type specificity . Positive_regulation EPHB2 TLR2 19265198 2063049 Heat shock protein gp96 interacts with protein phosphatase 5 and controls *mediated* activation of extracellular signal regulated kinase ( [ERK] ) 1/2 in post-hypoxic kidney cells . Positive_regulation EPHB2 TLR2 20190136 2229223 Bacterial teichoic acids reverse predominant IL-12 production induced by certain lactobacillus strains into predominant IL-10 production via *dependent* [ERK] activation in macrophages . Positive_regulation EPHB2 TLR2 20190136 2229228 The effect of these teichoic acids on IL-10 production was mediated by *dependent* [ERK] activation . Positive_regulation EPHB2 TLR2 20802527 2375222 In agreement with the result of mediated [ERK] *activation* by PAUF , PAUF induces increased expression of the protumorigenic cytokines RANTES and MIF in THP-1 cells . Positive_regulation EPHB2 TLR2 21660601 2470817 Neurotoxic effects of the HCV core protein are mediated by sustained *activation* of [ERK] via signaling . Positive_regulation EPHB2 TLR2 23556003 2767494 YCP interaction with and TLR4 *led* to the activation of intracellular p38 , [ERK] and JNK , as well as the translocation of transcriptional factor NF-?B into nucleus . Positive_regulation EPHB2 TLR2 23659921 2843689 Data presented herein demonstrate that TLR2 enhanced the tyrosine phosphorylation of Dok1 and Dok2 in astrocytes and microglia , and that knockdown of these adaptors using small interfering RNA robustly elevated *induced* [ERK] activation . Positive_regulation EPHB2 TLR2 23975865 2841288 Genes involved in RA biosynthesis and metabolism , such as Adh1 and Raldh2 , as well as RA receptors and IL-10 , were induced in dendritic cells (DCs) via *dependent* [ERK] signaling . Positive_regulation EPHB2 TLR2 24737107 2943021 mediated STAT3 and [ERK] *activation* controls IL-10 secretion by human B cells . Positive_regulation EPHB2 TLR3 16484370 1534808 Despite rescuing *dependent* [ERK] activation in nfkb1 ( -/- ) bone marrow derived macrophages by using an estrogen receptor regulated version of the mitogen activated protein 3 kinase , c-Raf ( Raf : ER ) , CpG or LPS induction of IL-10 was only partially restored in nfkb1 ( -/- ) cells expressing Raf : ER , a finding consistent with NF-kappaB1 regulating IL-10 by a combination of ERK independent and -dependent mechanisms . Positive_regulation EPHB2 TLR3 18355244 1957958 ISO-1 is a promising parent molecule which inhibits induced [ERK] *activation* and inflammatory cytokine production in monocytes , whose role may be complicated by cell-type specificity . Positive_regulation EPHB2 TLR3 24737107 2943022 mediated STAT3 and [ERK] *activation* controls IL-10 secretion by human B cells . Positive_regulation EPHB2 TLR4 15773898 1384575 Furthermore , overall cellular tyrosine phosphorylation and mediated *activation* of IkappaB-alpha , [Erk] and p38 but not of JNK , were also down-regulated in Csk knockdown cells . Positive_regulation EPHB2 TLR4 16484370 1534809 Despite rescuing dependent [ERK] *activation* in nfkb1 ( -/- ) bone marrow derived macrophages by using an estrogen receptor regulated version of the mitogen activated protein 3 kinase , c-Raf ( Raf : ER ) , CpG or LPS induction of IL-10 was only partially restored in nfkb1 ( -/- ) cells expressing Raf : ER , a finding consistent with NF-kappaB1 regulating IL-10 by a combination of ERK independent and -dependent mechanisms . Positive_regulation EPHB2 TLR4 16879219 1593854 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by [MEK/ERK] signaling and NFkappaB activation and that membrane bound CD14 and are *involved* in this mechanism . Positive_regulation EPHB2 TLR4 17237423 1690060 In this study , we show that pneumolysin is required for up-regulation of MUC5AC mucin via *dependent* activation of [ERK] in human epithelial cells in vitro and in mice in vivo . Positive_regulation EPHB2 TLR4 17507094 1750990 [ERK] *activation* in macrophages by and -7 is mediated via a MAP3K , called TPL2/COT , which under unstimulated conditions is associated with NF kappa B1 p105 , a member of the I kappa B family of proteins . Positive_regulation EPHB2 TLR4 17507094 1751010 These results suggest that while TRAF6 is absolutely essential for TLR7 activation of ERK , JNK and NF kappa B pathways , *induced* [ERK] , JNK pathways and IKK mediated phosphorylation of I kappa B family members as well as cytokine expression are differentially sensitive to the cellular levels of TRAF6 . Positive_regulation EPHB2 TLR4 18355244 1957959 ISO-1 is a promising parent molecule which inhibits *induced* [ERK] activation and inflammatory cytokine production in monocytes , whose role may be complicated by cell-type specificity . Positive_regulation EPHB2 TLR4 20506307 2307839 The activation of> *dependent* phosphorylation of ( p42/44 ) [ERK] and p38 MAPK by CD4 ( + ) monocytes . Positive_regulation EPHB2 TLR4 20843518 2353051 DPP-4 ( CD26 ) inhibitor alogliptin inhibits mediated [ERK] *activation* and ERK dependent MMP-1 expression by U937 histiocytes . Positive_regulation EPHB2 TLR4 20843518 2353058 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed mediated [ERK] *activation* and ERK dependent MMP expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation EPHB2 TLR4 21881005 2510430 Basolateral LPS inhibits NHE3 and HCOFormula absorption through *dependent* [ERK] activation in medullary thick ascending limb . Positive_regulation EPHB2 TLR4 22189943 2568727 In summary , UA after IRI mediates the acetylation and release of HMGB1 from endothelial cells by mechanisms that involve calcium mobilization , the [MEK/Erk] pathway , and *activation* of . Positive_regulation EPHB2 TLR4 22523073 2608014 Previously we demonstrated that basolateral LPS inhibits HCO ( 3 ) ( - ) absorption in the renal medullary thick ascending limb ( MTAL ) through *dependent* [ERK] activation . Positive_regulation EPHB2 TLR4 23556003 2767495 YCP interaction with TLR2 and *led* to the activation of intracellular p38 , [ERK] and JNK , as well as the translocation of transcriptional factor NF-?B into nucleus . Positive_regulation EPHB2 TLR4 23828139 2820818 *induced* activation of [ERK] and JNK signaling promotes cell proliferation through regulating Bax translocation to mitochondria . Positive_regulation EPHB2 TLR4 23960234 2836078 Morphine pretreatment prevented *dependent* [ERK] and IKK phosphorylation . Positive_regulation EPHB2 TLR4 24737107 2943023 mediated STAT3 and [ERK] *activation* controls IL-10 secretion by human B cells . Positive_regulation EPHB2 TLR5 16484370 1534810 Despite rescuing *dependent* [ERK] activation in nfkb1 ( -/- ) bone marrow derived macrophages by using an estrogen receptor regulated version of the mitogen activated protein 3 kinase , c-Raf ( Raf : ER ) , CpG or LPS induction of IL-10 was only partially restored in nfkb1 ( -/- ) cells expressing Raf : ER , a finding consistent with NF-kappaB1 regulating IL-10 by a combination of ERK independent and -dependent mechanisms . Positive_regulation EPHB2 TLR5 18355244 1957960 ISO-1 is a promising parent molecule which inhibits induced [ERK] *activation* and inflammatory cytokine production in monocytes , whose role may be complicated by cell-type specificity . Positive_regulation EPHB2 TLR5 22023165 2533760 Elevated IL-8 is accompanied by increased expression of TLR5 , both protein and mRNA , and by increased levels of *mediated* phosphorylation of MAPK p38 and [ERK] . Positive_regulation EPHB2 TLR5 24737107 2943024 mediated STAT3 and [ERK] *activation* controls IL-10 secretion by human B cells . Positive_regulation EPHB2 TLR6 16484370 1534815 Despite rescuing *dependent* [ERK] activation in nfkb1 ( -/- ) bone marrow derived macrophages by using an estrogen receptor regulated version of the mitogen activated protein 3 kinase , c-Raf ( Raf : ER ) , CpG or LPS induction of IL-10 was only partially restored in nfkb1 ( -/- ) cells expressing Raf : ER , a finding consistent with NF-kappaB1 regulating IL-10 by a combination of ERK independent and -dependent mechanisms . Positive_regulation EPHB2 TLR6 18355244 1957965 ISO-1 is a promising parent molecule which inhibits induced [ERK] *activation* and inflammatory cytokine production in monocytes , whose role may be complicated by cell-type specificity . Positive_regulation EPHB2 TLR6 24737107 2943029 mediated STAT3 and [ERK] *activation* controls IL-10 secretion by human B cells . Positive_regulation EPHB2 TLR7 16484370 1534811 Despite rescuing dependent [ERK] *activation* in nfkb1 ( -/- ) bone marrow derived macrophages by using an estrogen receptor regulated version of the mitogen activated protein 3 kinase , c-Raf ( Raf : ER ) , CpG or LPS induction of IL-10 was only partially restored in nfkb1 ( -/- ) cells expressing Raf : ER , a finding consistent with NF-kappaB1 regulating IL-10 by a combination of ERK independent and -dependent mechanisms . Positive_regulation EPHB2 TLR7 18355244 1957961 ISO-1 is a promising parent molecule which inhibits *induced* [ERK] activation and inflammatory cytokine production in monocytes , whose role may be complicated by cell-type specificity . Positive_regulation EPHB2 TLR7 24737107 2943025 mediated STAT3 and [ERK] *activation* controls IL-10 secretion by human B cells . Positive_regulation EPHB2 TLR8 16484370 1534812 Despite rescuing dependent [ERK] *activation* in nfkb1 ( -/- ) bone marrow derived macrophages by using an estrogen receptor regulated version of the mitogen activated protein 3 kinase , c-Raf ( Raf : ER ) , CpG or LPS induction of IL-10 was only partially restored in nfkb1 ( -/- ) cells expressing Raf : ER , a finding consistent with NF-kappaB1 regulating IL-10 by a combination of ERK independent and -dependent mechanisms . Positive_regulation EPHB2 TLR8 18355244 1957962 ISO-1 is a promising parent molecule which inhibits induced [ERK] *activation* and inflammatory cytokine production in monocytes , whose role may be complicated by cell-type specificity . Positive_regulation EPHB2 TLR8 24737107 2943026 mediated STAT3 and [ERK] *activation* controls IL-10 secretion by human B cells . Positive_regulation EPHB2 TLR9 16402377 1513180 Since both RANKL-RANK and interactions *result* in NF-kappaB activation , p38 and [ERK] phosphorylation , and TNF-alpha synthesis ( all implicated in osteoclastogenesis ) , we hypothesized that CpG-ODN ( but not RANKL ) in addition induces the synthesis of an anti-osteoclastogenic factor . Positive_regulation EPHB2 TLR9 16484370 1534813 Despite rescuing *dependent* [ERK] activation in nfkb1 ( -/- ) bone marrow derived macrophages by using an estrogen receptor regulated version of the mitogen activated protein 3 kinase , c-Raf ( Raf : ER ) , CpG or LPS induction of IL-10 was only partially restored in nfkb1 ( -/- ) cells expressing Raf : ER , a finding consistent with NF-kappaB1 regulating IL-10 by a combination of ERK independent and -dependent mechanisms . Positive_regulation EPHB2 TLR9 18355244 1957963 ISO-1 is a promising parent molecule which inhibits *induced* [ERK] activation and inflammatory cytokine production in monocytes , whose role may be complicated by cell-type specificity . Positive_regulation EPHB2 TLR9 24737107 2943027 mediated STAT3 and [ERK] *activation* controls IL-10 secretion by human B cells . Positive_regulation EPHB2 TMED7 10781803 687947 This implies that a link exists between [ERK] activation and p21 ( WAF ) and ( kip1 ) *induction* in the process of terminal differentiation . Positive_regulation EPHB2 TMEFF2 23936739 2826995 Using prostate cell lines , here we examine the *role* of in [ERK] and Akt activation , two pathways implicated in prostate cancer progression and that have been shown to cross talk in several cancers . Positive_regulation EPHB2 TMPO 11901221 921908 Although [ERK] *activation* through was dependent on 2- [ 1- ( dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF 109203X ) -sensitive protein kinase ( PK ) Cs , ERK activation through TPbeta was only partially dependent on PKCs . Positive_regulation EPHB2 TMPO 11901221 921910 [ERK] *activation* through both and TPbeta was dependent on PKA and phosphoinositide 3-kinase (PI3K) class 1 ( A ) , but not class 1 ( B ) , and was modulated by Harvey-Ras , A-Raf , c-Raf , and Rap1B/B-Raf and also involved transactivation of the epidermal growth factor receptor . Positive_regulation EPHB2 TMSB4X 16515784 1555049 [ERK] *activation* by overexpression induces paclitaxel-resistance . Positive_regulation EPHB2 TNF 10712344 673998 *induced* p38 MAP kinase and [Erk] phosphorylation , but neither SB 203580 nor PD 98059 inhibited RANTES production . Positive_regulation EPHB2 TNF 10913368 716288 Analysis of embryonal fibroblasts from FAN knockout mice revealed that *induced* activation of both [ERK] and cPLA(2) occurs without involvement of FAN . Positive_regulation EPHB2 TNF 10913368 716290 Furthermore , we provide evidence that the *dependent* activation of [ERK] and cPLA(2) requires the intact death domain of TNF-R55 . Positive_regulation EPHB2 TNF 11149911 780449 *mediated* activation of [MEK/ERK] and EGR-1 can be blocked by adenoviral expression of a dominant negative mutant of IKK2 , whereas the VEGF signaling pathway is unaffected . Positive_regulation EPHB2 TNF 11675379 888535 PD98059 , a specific inhibitor of the ERK activating kinase MEK-1 , abolished the *induced* [ERK] phosphorylation and osteoclast survival , and in these responses the involvement of Grb2 and ceramide was observed . Positive_regulation EPHB2 TNF 11781388 900339 These findings suggest that *induced* [ERK] activation negatively controls maturation and IL-12 production in murine DC . Positive_regulation EPHB2 TNF 12351429 992927 *activated* [ERK] and increased lipolysis ; Positive_regulation EPHB2 TNF 12472772 1032584 Western blotting showed that statins inhibited *induced* [ERK] phosphorylation in a dose dependent fashion , but had no effect on p38 . Positive_regulation EPHB2 TNF 12554784 1057037 , which *activates* three different MAPKs [[ERK] , p38 , and jun amino terminal kinase ( JNK ) ] , also induces insulin resistance . Positive_regulation EPHB2 TNF 12731668 1086841 On the other hand , GM-CSF- or *induced* phosphorylation of [ERK] and p38 MAPK was unaffected by these inhibitors at the concentrations effective for the inhibition of O2- release and adherence . Positive_regulation EPHB2 TNF 12887130 1116900 *had* no effect on either IRS-1 phosphorylation or [ERK] in VSMC . Positive_regulation EPHB2 TNF 12898507 1118491 We demonstrated that U0126 or PD98059 blocked *induced* [ERK] activity and decreased TNF-alpha induced lipolysis by 65 or 76 % respectively . Positive_regulation EPHB2 TNF 12898507 1118492 Pretreatment of adipocytes with these agents almost totally blocked *induced* [ERK] activation and reduced lipolysis by greater than 90 % . Positive_regulation EPHB2 TNF 14755547 1205637 Finally , the transient transfection of HASMC with dominant negative Ras ( RasN17 ) suppressed *induced* [ERK] activity , MMP-9 production , and promoter activity . Positive_regulation EPHB2 TNF 15265936 1275728 Besides NF-kappa B , celecoxib also suppressed *induced* JNK , p38 MAPK , and [ERK] activation . Positive_regulation EPHB2 TNF 15454113 1301140 Bis-indolylmaleimide , an inhibitor of protein kinase C , partially blocked the up-regulation of CD83 and [ERK] phosphorylation *induced* by PA and . Positive_regulation EPHB2 TNF 15589482 1356207 In addition , luteolin inhibited *induced* phosphorylation of p38 MAPK and [extracellular regulated kinases (ERK)] , IkappaB degradation , and NF-kappaB activation . Positive_regulation EPHB2 TNF 15659876 1350284 The anabolic effect of was *mediated* at least in part by mitogen activated protein kinase (MAPK) , especially by an [extracellular regulated kinases (ERK)] . Positive_regulation EPHB2 TNF 15696169 1372149 Selective regulation of *induced* [Erk] signaling by Src family kinases and the T cell protein tyrosine phosphatase . Positive_regulation EPHB2 TNF 15870903 1405542 In addition , GA inhibited *induced* phosphorylation of p38 MAPK and [extracellular regulated kinases (ERK)] , I kappa B alpha degradation , and NF-kappa B activation . Positive_regulation EPHB2 TNF 16129431 1461134 The Fas associated death domain protein/caspase-8/c-FLIP signaling pathway is involved in *induced* activation of [ERK] . Positive_regulation EPHB2 TNF 16129431 1461135 Therefore , we have analyzed *induced* [ERK] activation in various human and murine cell lines and show that it occurs in a cell-type-specific manner . Positive_regulation EPHB2 TNF 16129431 1461136 In addition , we provide evidence for the involvement of the signaling components Fas associated death domain protein ( FADD ) , caspase-8 , and c-FLIP in the pathway activating [ERK] in *response* to . Positive_regulation EPHB2 TNF 16129431 1461141 ( II ) *induced* [ERK] activation is strongly diminished in the absence of FADD . Positive_regulation EPHB2 TNF 16129431 1461142 Interestingly , the enzymatic function of caspase-8 is not required for *induced* [ERK] activation . Positive_regulation EPHB2 TNF 16207331 1464340 These data indicate that preferentially *activates* p38MAPKalpha and [ERK] in synovial membrane exposed to TNF . Positive_regulation EPHB2 TNF 16272352 1479491 PGE2 also blocked *stimulated* [ERK] activation , and the ERK inhibitor , PD98059 , mimicked PGE2 in blocking p65 , but enhancing p50 nuclear translocation , suggesting that the effects of PGE2 on p65 and p50 are mediated via effects on ERK . Positive_regulation EPHB2 TNF 16291755 1510580 *stimulates* the JNK , [ERK] , and p38 mitogen activated protein kinases and the NF-kappaB pathway by recruiting RIP1 and TRAF2 to the TNF receptor 1 . Positive_regulation EPHB2 TNF 16294327 1532383 Curcumin inhibited interleukin-1beta- and induced *activation* of activator protein-1 (AP-1) and mitogen activated protein ( MAP ) kinases ( [ERK] , c-Jun N-terminal kinase (JNK) , and p38 MAP kinase ) , but not of nuclear factor-kappaB (NF-kappaB) . Positive_regulation EPHB2 TNF 16418769 1495063 *induced* p38 and [ERK] activation , whereas oridonin triggered only ERK activation . Positive_regulation EPHB2 TNF 16632126 1552553 These results suggest that notoginsenoside R1 inhibits *induced* [ERK] activation and subsequent fibronectin overexpression and migration in HASMCs by suppressing NADPH oxidase mediated ROS generation and directly scavenging ROS . Positive_regulation EPHB2 TNF 16867053 1592823 We found that selective activation of PAR-2 using the peptide SLIGKV augmented *induced* MMP-9 protein levels and increased [ERK] phosphorylation . Positive_regulation EPHB2 TNF 16934445 1633033 and [ERK] regulates the up-regulation of MT1-MMP mRNA in *response* to . Positive_regulation EPHB2 TNF 17114809 1677175 [ERK] activation was also required for TNF-alpha stimulated DNA synthesis but likewise *induced* ERK activation was not blocked by inhibition of SphK . Positive_regulation EPHB2 TNF 17223661 1765546 In RA- and OA-SFB , *induced* phosphorylation of p38 , [ERK] or JNK was exclusively mediated by TNF-R1 . Positive_regulation EPHB2 TNF 17567906 1763219 Functionally , transiently overexpressed Zfra sequestered NF-kappaB ( p65 ) , WOX1 , p53 and [phospho-ERK] ( extracellular signal activated kinase ) in the cytoplasm , and or UV light could not effectively *induce* nuclear translocation of these proteins . Positive_regulation EPHB2 TNF 17607712 1798184 Although *induced* the activation of p38 MAPK , JNK , [ERK] and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation EPHB2 TNF 17913704 1830215 Together with cPLA(2) redistribution and AA release , *induced* a time dependent phosphorylation of [ERK] , MSK1 , PKCzeta , CaMKII , and phospholamban on the threonine 17 residue . Positive_regulation EPHB2 TNF 17979138 1894493 Tanshinone IIA inhibited *induced* [ERK] and c-jun phosphorylation , but not other MAPKs such as JNK and p38 . Positive_regulation EPHB2 TNF 18060043 1853597 In cultures of Schwann cells , astrocytes , and microglia , sLRP-alpha inhibited induced *activation* of p38 MAPK and [ERK/MAPK] . Positive_regulation EPHB2 TNF 18080320 1894750 By using the EGF receptor (EGFR) tyrosine kinase inhibitor , AG1487 and the Src family inhibitor , PP-1 , we established that *activated* [ERK] in an EGFR and Src dependent and an EGFR and Src independent modes . Positive_regulation EPHB2 TNF 18644347 1947745 On the other hand , Celecoxib had no effect on the *induced* nuclear translocation of c-jun and activation of [ERK] , JNK , p38 and Akt . Positive_regulation EPHB2 TNF 18656701 1942705 Moreover , p38 MAPK inhibitor was found to abrogate the *induced* [ERK] phosphorylation , suggesting that there was a one-way interaction between p38 MAPK and ERK pathways during the TNF-alpha activation . Positive_regulation EPHB2 TNF 18796294 1976163 Subsequently , *activated* [ERK] , JNK and p38 in apoptosis and autophagy , in which ERK/JNK played a promoting role whereas p38 played an inhibiting one . Positive_regulation EPHB2 TNF 18977218 1995149 Increased [ERK] phosphorylation was detected upon *stimulation* with Phenylephrine ( 2.6+/-0.1 times over basal ) , Endothelin-1 ( 1.8+/-0.2 ) , Dopamine ( 5.1+/-0.2 ) , ( 9.8+/-0.7 ) or IL-4 ( 3.1+/-0.3 ) . Positive_regulation EPHB2 TNF 19110010 2036650 In these cells , TPA stimulation but not , *activated* extracellular signal regulated kinase ( [ERK] ) . Positive_regulation EPHB2 TNF 19144181 2079120 Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by *induced* [MEK/ERK] signalling . Positive_regulation EPHB2 TNF 19144181 2079128 *activates* mitogen activated kinase kinase [(MEK)/extracellular regulated kinase (ERK)] in chondrocytes ; Positive_regulation EPHB2 TNF 19320886 2052448 at 50 microg/L *increased* the expression of [phospho-ERK] and phospho-p38 , and SB203580 , but not PD98059 , could suppress the chemotaxis effect and up-regulation of ICAM-1 induced by TNF-alpha in MSCs ( p < 0.05 ) . Positive_regulation EPHB2 TNF 19429670 2106851 Ang II and clearly *enhanced* [ERK] and p38MAPK phosphorylation . Positive_regulation EPHB2 TNF 19628074 2112816 and/or TGF-alpha stimulation *increased* phospho-MEK and [phospho-ERK] in cells transfected with TNFR1 siRNA . Positive_regulation EPHB2 TNF 19786304 2163911 We further demonstrate that Egr-1 induction is triggered by *dependent* [ERK] activation , and inhibition of this pathway ablates Egr-1 expression . Positive_regulation EPHB2 TNF 19945429 2198959 In rat adult VSMCs , adenoviral over-expression of UCH-L1 inhibited *induced* activation of [ERK] and DNA synthesis . Positive_regulation EPHB2 TNF 20049872 2200698 *activated* [ERK] and increased NF-kappaB promoter activity . Positive_regulation EPHB2 TNF 20357815 2287676 cAMP inhibited *stimulated* [ERK] and JNK activation , which was shown to have an important role in MMP-1 expression . Positive_regulation EPHB2 TNF 20691248 2311984 This study aims to elucidate the beneficial *role* of and HSP-70 in the regulation of apoptotic proteins and [ERK] signaling in hypoxic injury . Positive_regulation EPHB2 TNF 20693316 2351473 In four of the six donors , basal and *induced* [ERK] and p38 MAPK activation were higher in ASMA than ASMNA cells . Positive_regulation EPHB2 TNF 21212278 2408307 Surprisingly , *induced* [ERK] and RhoA stimulation in tubular cells were prevented by epidermal growth factor receptor (EGFR) inhibition or silencing . Positive_regulation EPHB2 TNF 21256190 2398037 Hypertonicity enhanced release from activated human monocytic THP-1 cells *requires* [ERK] activation . Positive_regulation EPHB2 TNF 21256190 2398039 Hypertonicity enhanced protein synthesis from LPS- or PMA activated THP-1 cells *requires* [ERK] activation and may proceed without TACE . Positive_regulation EPHB2 TNF 21556737 2574022 *induced* [ERK] and NF-?B activation was suppressed in FLS with RKIP overexpression . Positive_regulation EPHB2 TNF 21557215 2521413 In the in vitro lipolysis models , YC-1 attenuates TNF-a induced lipolysis of adipocytes by antagonizing mediated *activation* of [ERK] and downregulation of perilipin (PLIN) . Positive_regulation EPHB2 TNF 21705614 2465725 Furthermore , luteolin inhibited *induced* phosphorylation of mitogen activated protein kinase/extracellular signal regulated kinase ( ERK ) kinase [1/ERK/p90] ( RSK ) , mitogen activated protein kinase kinase 4/c-Jun N-terminal kinase/c-Jun , and Akt/p70 ( S6K ) . Positive_regulation EPHB2 TNF 21806874 2462487 Pretreatment of PD98059 or U0126 inhibited *induced* IL-6 release and [ERK] phosphorylation in P815 cells ( P < 0.05 ) , whereas pretreatment of SB203580 or AG490 hardly affect IL-6 release , with little effect on phosphorylation of p38 and STAT3 respectively . Positive_regulation EPHB2 TNF 22155163 2568524 Sulforaphane also suppressed *induced* production of intracellular reactive oxygen species ( ROS ) and activation of p38 , [ERK] and JNK . Positive_regulation EPHB2 TNF 22396737 2566835 Further studies show that these antagonistic actions occur via mechanisms involving GILZ inhibition of *induced* [ERK] MAP kinase activation and protein degradation . Positive_regulation EPHB2 TNF 22733995 2639206 The Nfkb1 ( SSAA ) mutation prevented the agonist induced release of TPL-2 from its inhibitor p105 , which blocked *activation* of [ERK] by lipopolysaccharide (LPS) , , CpG , tripalmitoyl-Cys-Ser-Lys ( Pam ( 3 ) CSK ) , poly ( I · C ) , flagellin , and R848 . Positive_regulation EPHB2 TNF 22777765 2715528 Blocking FPR2 using the specific antagonist WRW4 mimicked the effects of AnxA1 silencing on *induced* proliferation , IL-6 , [ERK] , and NF-?B activation . Positive_regulation EPHB2 TNF 22842465 2646576 Omentin pretreatment significantly inhibited *induced* [ERK] activity and ERK phosphorylation in HUVECs . Positive_regulation EPHB2 TNF 22988345 2674392 TNF-a treatment of IECs resulted in an association between EGFR and HER2 and inhibition of HER2 using a specific inhibitor AG879 in combination with AG1478 suppressed *dependent* [ERK] phosphorylation and IL-8 release . Positive_regulation EPHB2 TNF 23184810 2718248 Furthermore , we show that pentoxifylline and propentofylline also inhibit JNK and p38 , but not [ERK] , activation *induced* by . Positive_regulation EPHB2 TNF 23397250 2787079 IL-33 *induces* CCL2 , and nitric oxide release through phosphorylation of [ERK] in mouse astrocytes . Positive_regulation EPHB2 TNF 23619565 2804767 Further studies revealed that PL suppressed the production of or Interleukin (IL)-6 and *activation* of nuclear factor-?B ( NF-?B ) or [extracellular regulated kinases (ERK)] 1/2 by LPS . Positive_regulation EPHB2 TNF 23628701 2795629 This inhibitory effect of AGGF1 was further proved through blocking the phosphorylation of [ERK] *induced* by . Positive_regulation EPHB2 TNF 23729444 2801851 GILZ overexpression also inhibited *induced* activation of p38 , [ERK] , and JNK MAPKs , as well as increased expression of the MAPK inhibitory phosphatase , MKP-1 . Positive_regulation EPHB2 TNF 23734186 2796952 This increased secretion of and IL-6 and *activation* of NF-kB , [ERK] , and JNK was significantly inhibited by the addition of either mannan or mannose . Positive_regulation EPHB2 TNF 23835476 2820890 Mlkl-deficient MEFs and macrophages were indistinguishable from wild-type cells in their ability to activate NF-?B , [ERK] , JNK , and p38 in *response* to and lipopolysaccharides (LPS) , respectively . Positive_regulation EPHB2 TNF 23839108 2816110 Western blot analysis revealed that EGCG treatment prevented IL-1ß/IL-4 or *induced* [ERK] and JNK activation in HGFs . Positive_regulation EPHB2 TNF 23942237 2840872 Canonical NF-?B and [ERK] activation , *mediated* by the receptor superfamily receptors CD40 and TACI , was impaired in B cells from B-HOIP ( ?linear ) mice due to defective activation of the IKK complex ; Positive_regulation EPHB2 TNF 24262867 2898243 Further studies revealed that PT suppressed the production of or Interleukin (IL)-6 and *activation* of nuclear factor-?B ( NF-?B ) or [extracellular regulated kinases (ERK)] 1/2 by LPS . Positive_regulation EPHB2 TNF 24345501 2880888 *stimulated* significantly phosphorylation on Ser536 of NF-?B/p65 , Ser473 of Akt at 5-15 min , and activations of IKK-ß and [ERK] at 15-30 min. Diosgenin ( 1 µmol · Positive_regulation EPHB2 TNF 9770326 538797 Furthermore , *induction* of p42/p44 [ERK] and p38-MAPK phosphorylation , c-jun kinase activation , and IkappaBalpha degradation were normal . Positive_regulation EPHB2 TNFAIP1 21665194 2446299 Mitogen activated protein kinase kinase inhibitors and alpha7-nicotinic acetylcholine receptor ( a7nAChR ) antagonist blocked the neurite outgrowth and the activation of [ERK] *induced* by . Positive_regulation EPHB2 TNFRSF10A 19786087 2209051 Combined treatment with esculetin and HA14-1 upregulated the expression of , and *activation* of [extracellular regulated kinase (ERK)] in a time dependent manner . Positive_regulation EPHB2 TNFRSF11A 16402377 1513178 Since both and CpG-ODN-TLR9 interactions *result* in NF-kappaB activation , p38 and [ERK] phosphorylation , and TNF-alpha synthesis ( all implicated in osteoclastogenesis ) , we hypothesized that CpG-ODN ( but not RANKL ) in addition induces the synthesis of an anti-osteoclastogenic factor . Positive_regulation EPHB2 TNFRSF11B 19748486 2147287 directly increased ALP activity and in vitro mineralization of HOC , enhanced expression of the vitronectin receptor thereby increasing adherence of HOC to vitronectin and *stimulated* [ERK] phosphorylation . Positive_regulation EPHB2 TNFRSF11B 20331738 2287559 induces cytoskeletal reorganization and *activates* FAK , Src , and [ERK] signaling in endothelial cells . Positive_regulation EPHB2 TNFRSF11B 24126801 2858887 increased chondrocyte proliferation with maximal effect at 10 ng/ml , and *induced* the phosphorylation of MEK and [ERK] but not P38MAPK or JNK . Positive_regulation EPHB2 TNFRSF1A 17223661 1765547 In RA- and OA-SFB , TNFalpha induced phosphorylation of p38 , [ERK] or JNK was exclusively *mediated* by . Positive_regulation EPHB2 TNFRSF1A 17292586 1725852 *induced* NF-kappaB , but not [ERK] , p38MAPK or JNK activation , mediates TNF induced ICAM-1 and VCAM-1 expression on endothelial cells . Positive_regulation EPHB2 TNFRSF1A 21315038 2393342 therefore our results suggest that lipid raft is essential for TNFR1 mediated AKT phosphorylation , but is dispensable for *mediated* degradation of I?Ba , activation of [ERK] or p38 and processing of caspase-3 . Positive_regulation EPHB2 TNFRSF25 16982754 1617160 Thereafter , we accumulated several results , suggesting that is an E-selectin receptor on colon cancer cells and that its activation by E-selectin *triggers* the activation of p38 and extracellular signal regulated kinase ( [ERK] ) mitogen activated protein kinase (MAPK) and confers migration and survival advantages . Positive_regulation EPHB2 TNFRSF25 17023523 1674249 Here we showed that JNK activator anisomycin *induced* phosphorylation through JNK1 rather than p38 and [ERK] signals , which is mediated by its upstream factors MAPK kinase 4 and MAPK kinase 7 . Positive_regulation EPHB2 TNFRSF6B 21420502 2448020 increased chondrocytes proliferation and *induced* the phosphorylation of [ERK] specifically . Positive_regulation EPHB2 TNFRSF8 12689928 1106074 Activation of , CD40 , and receptor activator of nuclear kappabeta ( RANK ) receptors in HD cells by their respective ligands *increased* [ERK] phosphorylation above the basal level and promoted HD cell survival . Positive_regulation EPHB2 TNFRSF8 15291361 1278674 Furthermore , stimulation of *led* to the activation of the p38 MAP kinase but not of the extracellular signal regulated kinase ( [ERK] ) or the jun N-terminal kinase ( JNK ) . Positive_regulation EPHB2 TNFSF10 12807432 1101891 rapidly ( from 20 min ) *induced* the phosphorylation of Akt and [ERK] , but not of c-Jun NH2-terminal kinase (JNK) . Positive_regulation EPHB2 TNFSF10 16865237 1592679 Simultaneously , silencing of hPEBP4 in CaoV-3 cells enhances *induced* [ERK] and JNK activation . Positive_regulation EPHB2 TNFSF10 17097066 1644675 *mediated* activation of [ERK] and JNK were also observed in parent MDA-231 cells but not in MDA-231/TR cells . Positive_regulation EPHB2 TNFSF10 24308965 2904858 HSP27 phosphorylation modulates *induced* activation of [Src-Akt/ERK] signaling through interaction with ß-arrestin2 . Positive_regulation EPHB2 TNFSF10 24308965 2904862 In addition , reduced HSP27 phosphorylation by KRIBB3 treatment or MK2 knockdown attenuated the induced *activation* of Akt and [ERK] survival signaling through suppressing the phosphorylation of Src . Positive_regulation EPHB2 TNFSF11 11719504 904129 We find that although pretreatment of BMMs with IL-4 does not alter M-CSF signaling , it reversibly blocks dependent *activation* of the NF-kappa B , JNK , p38 , and [ERK] signals . Positive_regulation EPHB2 TNFSF11 12821717 1104224 These findings indicate that Cot/Tpl2 is essential for LPS induced [ERK] activation and *induction* in osteoblasts . Positive_regulation EPHB2 TNFSF11 12893832 1142984 VEGF potentiated *induced* [ERK] activation and tube formation via RANK up-regulation in HUVECs . Positive_regulation EPHB2 TNFSF11 14672351 1178456 Assays for NF-kappaB nuclear translocation , NF-kappaB reporter gene activity , protein kinase activity , and Western blotting were used to examine the effects of TPA on *induced* NF-kappaB , c-Jun N-terminal kinase (JNK) , and [MEK/ERK] and p38 signal transduction pathways . Positive_regulation EPHB2 TNFSF11 14672351 1178472 TPA also inhibited *induced* activation of [ERK] but had little effect on p38 activation . Positive_regulation EPHB2 TNFSF11 15013839 1220711 M-CSF and *activate* the [ERK] , Akt , and NF-kappaB signal transduction pathways , and SCOH suppressed this activation . Positive_regulation EPHB2 TNFSF11 15081864 1234228 *activated* the [ERK] , Akt , and NF-kappaB signal transduction pathways in osteoclast precursor cells , and tanshinone IIA suppressed this activation . Positive_regulation EPHB2 TNFSF11 15389575 1354284 Conversely , using reporter gene assays and Western blot analysis , we have demonstrated that high extracellular Ca2+ desensitizes the RANKL induced activation of NF-kappaB and c-Jun N-terminal kinase (JNK) , and inhibits constitutive and *stimulated* [ERK] phosphorylation , indicating a negative feed-back mechanism via specific RANKL signaling pathways . Positive_regulation EPHB2 TNFSF11 15530848 1332702 Pretreatment of osteoclasts with the antioxidants N-acetyl-l-cystein and glutathione reduced *induced* Akt , NF-kappaB , and [ERK] activation . Positive_regulation EPHB2 TNFSF11 16328004 1503609 Results revealed a *induced* increase in [ERK] phosphorylation , as well as BMP-2 induction at the mRNA and protein levels , and a decrease of POS-1 cell proliferation in the presence of 10 ng/ml RANKL . Positive_regulation EPHB2 TNFSF11 16402377 1513179 Since both and CpG-ODN-TLR9 interactions *result* in NF-kappaB activation , p38 and [ERK] phosphorylation , and TNF-alpha synthesis ( all implicated in osteoclastogenesis ) , we hypothesized that CpG-ODN ( but not RANKL ) in addition induces the synthesis of an anti-osteoclastogenic factor . Positive_regulation EPHB2 TNFSF11 16622189 1551593 *induced* phosphorylation of [ERK] , p38 , and NF-kappaB was not suppressed by HbR , but that of Akt was markedly suppressed . Positive_regulation EPHB2 TNFSF11 17477372 1761423 KN-93 and KN-62 both inhibited *induced* [ERK] phosphorylation and CREB transcriptional activity . Positive_regulation EPHB2 TNFSF11 17504945 1772689 On the other hand , DMS strongly inhibited two separate signaling pathways , the *induced* activation of [ERK] and Akt , which eventually converged on the transcription factors c-Fos and NFATc1 . Positive_regulation EPHB2 TNFSF11 17646068 1780318 CE-C suppressed the *activation* of extracellular signal regulated kinase ( [ERK] ) , protein kinase B ( PKB/Akt ) and inhibitor of kappa B ( I-kappaB ) by in osteoclast precursor cells . Positive_regulation EPHB2 TNFSF11 18251700 1919198 *activates* [Elk related tyrosine kinase (ERK)] , p38 , c-Jun N-terminal kinase (JNK) , and NF-kappaB pathways through TRAF6 in osteoclasts and the precursor cells . Positive_regulation EPHB2 TNFSF11 18495114 1917405 However , *induced* [ERK] , p38 but not JNK phosphorylation was attenuated by paeonol . Positive_regulation EPHB2 TNFSF11 18495114 1917413 Our data suggest that paeonol inhibits osteoclastogenesis from bone marrow stromal cells and macrophage cells via attenuated of *induced* [ERK] , p38 and NF-kappaB activation , which in turn protect bone loss from ovariectomy . Positive_regulation EPHB2 TNFSF11 18506384 2010423 Additionally , water solution of onion crude powder inhibits the *induced* [ERK] , p38 and NF-kappaB activation in macrophages . Positive_regulation EPHB2 TNFSF11 18506384 2010427 Our data suggest that water solution of onion crude powder inhibits osteoclastogenesis from co-cultures of bone marrow stromal cells and macrophage cells via attenuation of *induced* [ERK] , p38 and NF-kappaB activation . Positive_regulation EPHB2 TNFSF11 18728019 1975244 Importantly , PLCgamma2 deficiency severely impaired RANKL signaling , resulting in marked reduction of *induced* activation of MAPKs , p38 and JNK , but not [ERK] . Positive_regulation EPHB2 TNFSF11 20112358 2206314 IL-27 inhibited human osteoclastogenesis , suppressed the induction of NFATc1 , down-regulated the expression of RANK and triggering receptor expressed on myeloid cells 2 ( TREM-2 ) , and inhibited mediated *activation* of [ERK] , p38 , and NF-kappaB in osteoclast precursors . Positive_regulation EPHB2 TNFSF11 20361312 2231884 Interestingly , cantharidin significantly inhibited *induced* [ERK/MAP] kinase activation and protein phosphatase 2A (PP2A) activity . Positive_regulation EPHB2 TNFSF11 20683903 2368087 Mangiferin attenuates osteoclastogenesis , bone resorption , and *induced* activation of NF-?B and [ERK] . Positive_regulation EPHB2 TNFSF11 20683903 2368088 In addition , mangiferin also exhibited an inhibitory effect on *induced* [ERK] phosphorylation . Positive_regulation EPHB2 TNFSF11 20850430 2331419 However , *induced* p38 and JNK but not [ERK] phosphorylation was attenuated by isoflavone derivatives . Positive_regulation EPHB2 TNFSF11 21114291 2355413 Its inhibitory activity was confirmed by in vitro evaluations including specific inhibition of *induced* [ERK] phosphorylation and NF-?B transcriptional activation . Positive_regulation EPHB2 TNFSF11 21362286 2399768 An analysis of a signaling pathway showed that AM630 inhibited the *induced* activation of [ERK] , but not NF-?B . Positive_regulation EPHB2 TNFSF11 21553650 2429323 While the combination of beta-glycerophosphate and ascorbic acid inhibited *stimulated* activation of [ERK] and p38 , and degradation of IkappaB , it increased the induction of c-Fos and NFATc1 . Positive_regulation EPHB2 TNFSF11 21725611 2471461 Stimulation by *induced* the phosphorylation of mitogen activated protein kinases ( MAPKs ) ( [ERK] , p38 , JNK ) , and specific inhibitors of MAPKs blocked RANKL induced cell migration . Positive_regulation EPHB2 TNFSF11 21835177 2473015 In addition , naringin inhibited *induced* phosphorylation of [ERK] . Positive_regulation EPHB2 TNFSF11 22034016 2540022 Paclitaxel inhibits osteoclast formation and bone resorption via influencing mitotic cell cycle arrest and *induced* activation of NF-?B and [ERK] . Positive_regulation EPHB2 TNFSF11 22037580 2508124 Furthermore , treatment with this limonoid suppressed induced *activation* of p38 , MAPK and [Erk] and nuclear localization of NF-?B p65 . Positive_regulation EPHB2 TNFSF11 22484180 2595322 In defining the signaling pathways , ginsenoside Rh2 was shown to moderately inhibit NF-?B activation and [ERK] phosphorylation in *response* to stimulation in BMM cells without any effect on p38 and c-Jun N-terminal kinase (JNK) . Positive_regulation EPHB2 TNFSF11 22795564 2697088 Myricetin also inhibited the *stimulated* activation of p-38 , [ERK] and cSrc signaling , and inhibited the RANKL stimulated degradation of I ( k ) B in the RAW264.7 cells . Positive_regulation EPHB2 TNFSF11 23000100 2689141 NecroX-7 significantly inhibited the NF-?B signaling pathway without affecting the activation of the mitogen activated protein kinases ( MAPKs ) JNK , p38 , and [ERK] in *response* to . Positive_regulation EPHB2 TNFSF11 23246654 2737135 While ApoE did not affect the *activation* of [ERK] , JNK , and p38 MAPK signaling pathways by , the phosphorylation of p65 trans-activation domain on serine 536 and transcription activity of NF-?B were reduced by ApoE overexpression . Positive_regulation EPHB2 TNFSF11 23261473 2732438 Sanguinarine inhibits osteoclast formation and bone resorption via suppressing induced *activation* of NF-?B and [ERK] signaling pathways . Positive_regulation EPHB2 TNFSF11 23261473 2732439 In addition , sanguinarine also affected the ERK signaling pathway by inhibiting *induced* [ERK] phosphorylation . Positive_regulation EPHB2 TNFSF11 23293355 2733054 LC8 also inhibited *induced* activation of JNK and [ERK] . Positive_regulation EPHB2 TNFSF11 23546287 2763029 CPC also inhibited induced *activation* of extracellular signal regulated kinase ( [ERK] ) and NF-?B and expression of cyclooxygenase (COX)-2 . Positive_regulation EPHB2 TNFSF12 23457623 2749549 Finally , western blot data revealed that can *induce* phosphorylation of p38 , JNK and [ERK] in HDMECs . Positive_regulation EPHB2 TNFSF13B 18713867 1955640 *activates* Akt and [Erk] through BAFF-R in an IKK1 dependent manner in primary mouse B cells . Positive_regulation EPHB2 TNFSF13B 18713867 1955646 It was also recently shown that *induces* sustained [Erk] activation and increased turnover of the proapoptotic molecule Bim . Positive_regulation EPHB2 TNFSF14 19939453 2198756 in combination with IFN-gamma *resulted* in increased activation of p38 MAPK , [ERK] and IkappaB-alpha compared with TNFSF14 or IFN-gamma alone . Positive_regulation EPHB2 TNFSF15 20863486 2337133 *induces* the expression of TGF-ß-inducible gene h3 ( ßig-h3 ) through PKC , PI3K , and [ERK] in THP-1 cells . Positive_regulation EPHB2 TNIP2 16633345 1562921 Here , using antigen presenting cells from ABIN-2-deficient mice , we show that was *required* for optimal activation of [Erk] induced by receptors that signal via TPL-2 , including Toll-like receptor 4 and tumor necrosis factor receptor 1 in macrophages , and CD40 in B cells . Positive_regulation EPHB2 TP53 15078887 1257708 Repressing with pifithrin-alpha or small interfering RNA *increased* [ERK] phosphorylation by H ( 2 ) O ( 2 ) , indicating that p53 dependent suppression of ERK activity may contribute to the bi-stable single cell responses observed . Positive_regulation EPHB2 TP53 15880691 1432985 Mutation or suppression of in MDA-MB231 and MCF7-E6 cells , respectively , *resulted* in a strong [ERK] phosphorylation in the presence of metals . Positive_regulation EPHB2 TP53 17208232 1688969 *regulates* [ERK] activation in carboplatin induced apoptosis in cervical carcinoma : a novel target of p53 in apoptosis . Positive_regulation EPHB2 TP53 18288380 1872679 Studies on the regulation of apoptosis showed that apicidin induces the up-regulation of and the downstream *activation* of [ERK] in MCF10A-ras cells . Positive_regulation EPHB2 TP53 21468663 2428117 Moreover , the pretreatment with trichostatin A ( TSA , a histone deacetylase inhibitor ) or TSA in combination with etoposide significantly sensitized HCC cells to apoptosis by inhibiting [ERK] phosphorylation , reactivating caspases and PARP , and *inducing* translocation of and Bid to cytoplasm . Positive_regulation EPHB2 TP53 21963806 2507349 These results provide the first evidence that sappanchalcone suppresses oral cancer cell growth and induces apoptosis through the activation of *dependent* mitochondrial , p38 , [ERK] , JNK , and NF-?B signaling . Positive_regulation EPHB2 TP53 22466960 2583237 Moreover , [ERK] activation upregulated Beclin-1 expression through induction of Bcl-2 phosphorylation , but did not *induce* Bcl-2 phosphorylation . Positive_regulation EPHB2 TPO 10438715 634932 In both systems , extracellular signal regulated protein kinase ( [ERK] ) 1 and 2 MAPK phosphorylation was rapidly *induced* by stimulation . Positive_regulation EPHB2 TPO 11535599 868945 One known pathway by which *induces* [ERK] activation is through the association of Shc with the penultimate phosphotyrosine within the TPO receptor , Mpl . Positive_regulation EPHB2 TPO 11535599 868946 Using BaF3 cells expressing a truncated Mpl ( T69Mpl ) as a tool to identify non-Shc/Ras dependent signaling pathways , we describe here novel mechanisms of *induced* [ERK] activation mediated , in part , by phosphoinositide 3-kinase (PI3K) . Positive_regulation EPHB2 TPO 11535599 868947 PKCzeta and PI3K also contribute to *induced* [ERK] activation in MKs , confirming their physiological relevance . Positive_regulation EPHB2 TPO 11874466 918781 Further evidence for differential regulation of RAS and ERK is provided by the observations that , which activates RAS but not protein kinase C , does not *activate* [ERK] , and that the inhibitor of SRC kinases PP1 inhibits activation of RAS but not ERK2 in response to thrombin . Positive_regulation EPHB2 TPO 14576068 1218550 Raf-1 is not required for megakaryocytopoiesis or *induced* [ERK] phosphorylation . Positive_regulation EPHB2 TPO 9271377 450297 In BAF3-mpl cells , *triggered* a weak and transient [ERK] activation , similar to that induced in UT7-mpl delta3 cells . Positive_regulation EPHB2 TRAF6 12902324 1150288 Overexpression of *suppressed* CpG DNA mediated activation of p38 and JNK , but not [ERK] , explaining the partial inhibitory effects of DN-TRAF6 on CpG DNA induced COX2-3'-UTR-luciferase activity . Positive_regulation EPHB2 TRAF6 17507094 1751011 These results suggest that while is absolutely *essential* for TLR7 activation of [ERK] , JNK and NF kappa B pathways , TLR4 induced ERK , JNK pathways and IKK mediated phosphorylation of I kappa B family members as well as cytokine expression are differentially sensitive to the cellular levels of TRAF6 . Positive_regulation EPHB2 TRAF6 23536866 2762744 Furthermore , our mechanistic studies indicated that NOR obviously suppressed the ubiquitination of TRAF6 , the accumulation of complexes and the *activation* of [ERK] and p38 MAPK , and reduced the nuclear translocation of NF-?B-p65 and DNA binding activity of NF-?B . Positive_regulation EPHB2 TRAF6 9432981 482441 Here we report that transient expression of *stimulated* both [ERK] and NF kappa B activity in the 293 cell line . Positive_regulation EPHB2 TRAF6 9432981 482444 Coexpression of the dominant negative H-Ras did not affect TRAF6 mediated ERK activity , suggesting that may *activate* [ERK] along a Ras independent pathway . Positive_regulation EPHB2 TREM2 24383713 2917311 Western blot data showed that silencing of *inhibited* phosphorylation of Akt , but not [ERK] , JNK or P38 . Positive_regulation EPHB2 TRH 10940738 721083 [ERK] *activation* by VIP or PACAP38 and were additive and both sensitive to the MEK inhibitors PD98059 and U0126 . Positive_regulation EPHB2 TRH 12351703 993011 D2S stimulation also decreased *induced* [MAPK/ERK] kinase phosphorylation . Positive_regulation EPHB2 TRH 18824214 1987697 In static culture , [ERK] *activation* by continuous was maximal at 10 min and persisted for up to 60 min , with a return to the basal level by 2h . Positive_regulation EPHB2 TRH 18824214 1987699 Stimulation with continuous in perifused cells *resulted* in a similar level of [ERK] phosphorylation . Positive_regulation EPHB2 TRH 18824214 1987703 however , prolactin gene transcription is not entirely determined by the strength or duration of *induced* [ERK] activation . Positive_regulation EPHB2 TRH 19289102 2063926 *induced* [ERK] activation was significantly enhanced in this condition . Positive_regulation EPHB2 TRH 22641014 2632593 In addition , *induced* [ERK] ( Extracelluar signal regulated kinase ) activation was enhanced in the presence of NKB . Positive_regulation EPHB2 TRIB1 20610816 2327792 The C-terminal ILLHPWF motif that is well conserved among Trib family proteins is required for MEK1 binding , *enhancement* of [ERK] phosphorylation , enhanced self-renewal activity of bone marrow cells and leukemogenic activity by . Positive_regulation EPHB2 TRIB1 22294728 2570835 The bone marrow transfer experiment showed that acute myeloid leukemia development was accelerated by transducing murine bone marrow cells with the R107L mutant in which *enhancement* of [ERK] phosphorylation and C/EBPa degradation by expression was even greater than in those expressing wild-type . Positive_regulation EPHB2 TRNAI1 21042538 2344359 Pam ( 3 ) CSK ( 4 ) and strongly *enhanced* osteogenic differentiation and [ERK] phosphorylation in hUCB-MSCs , and LPS and MDP also slightly did . Positive_regulation EPHB2 TRO 17982257 1821195 Preventing *induced* [ERK] activation did not restore DNA synthesis or cellular pH . Positive_regulation EPHB2 TRPC6 23645677 2800583 Through medium transfer experiments , we uncovered two distinct mechanisms for [ERK] *activation* by mutant , a cell-autonomous , EGF receptor independent mechanism and a non-cell-autonomous mechanism involving metalloprotease mediated release of a presumed EGF receptor ligand . Positive_regulation EPHB2 TRPC6 23645677 2800597 Phosphorylation of Thr-70 , Ser-282 , and Tyr-31/285 were not necessary for [ERK] *activation* by mutant , although a phosphomimetic TRPC6 S282E mutant was capable of ERK activation . Positive_regulation EPHB2 TRPV1 18684647 2028120 Vanilloid receptor *mediated* phosphorylation of [ERK] in murine adjuvant arthritis . Positive_regulation EPHB2 TRPV1 18684647 2028121 One possibility is that downstream effects of activation of are *mediated* by the [extracellularly regulated kinase (ERK)] . Positive_regulation EPHB2 TRPV1 20660715 2311036 Specific inhibition of EGFR and TRPV1 indicated that capsaicin induced [ERK] activation in A431 cells was *dependent* on EGFR , but not . Positive_regulation EPHB2 TUFM 24275659 2898380 The c-FLIPL cleavage product *promotes* activation of extracellular signal regulated kinase ( [ERK] ) , nuclear factor ?B ( NF-?B ) , and caspase-8 and T cell survival . Positive_regulation EPHB2 TXN 20430109 2288046 Japanese encephalitis virus down-regulates and *induces* ROS mediated [ASK1-ERK/p38] MAPK activation in human promonocyte cells . Positive_regulation EPHB2 TYR 11085989 810058 The phosphatase activity of SHP-2 is required for both pathways , whereas *activation* of [ERK] via of ObRb also requires tyrosine phosphorylation of SHP-2 . Positive_regulation EPHB2 TYR 11830491 909929 Analysis of these cell lines indicated that induction of Gab2WT expression , but not expression , *led* to [Erk] activation , growth arrest , cell spreading , and enlargement ; Positive_regulation EPHB2 TYR 23318428 2860727 Phosphatase-active and -inactive , and wild-type Shp2s bound equally to Grb2 , suggesting that phosphorylation of of Shp2 was *essential* but not sufficient for Shp2 mediated [Erk] activation . Positive_regulation EPHB2 TYR 23645677 2800598 Phosphorylation of Thr-70 , Ser-282 , and were not *necessary* for [ERK] activation by mutant TRPC6 , although a phosphomimetic TRPC6 S282E mutant was capable of ERK activation . Positive_regulation EPHB2 UCN 19211730 2054253 *induces* interleukin-6 release from rat cardiomyocytes through p38 MAP kinase , [ERK] and NF-kappaB activation . Positive_regulation EPHB2 UCN 19211730 2054262 *stimulates* activation of [ERK] and p38 MAP kinases , while both MEK1 and p38 inhibitor block Ucn induced IL-6 release . Positive_regulation EPHB2 UCN 19211730 2054269 Finally , the CRH-R antagonists alpha-helical ( 9-41 ) CRH and astressin-2B completely inhibit *induced* IL-6 release , as well as activation of [ERK] , p38 , and NF-kappaB . Positive_regulation EPHB2 UFD1L 10648884 662337 depolarization *induced* calcium increases activated both [ERK] and p38 kinase within 5 min . Positive_regulation EPHB2 ULK1 16014626 1453151 We found previously that inhibition of HGF induced proliferation in HepG2 hepatoma cells is *caused* by cell cycle arrest through a high intensity [ERK] signal , which represses Cdk2 activity . Positive_regulation EPHB2 UMOD 24269936 2898328 Therefore , the current study aims to examine the *roles* of in the development and expression of METH induced locomotor sensitization as well as the accompanying [extracellular regulated kinase (ERK)] activation in the nucleus accumbens (NAc) , caudate putamen (CPu) and prefrontal cortex (PFc) in mice . Positive_regulation EPHB2 UTP15 10026223 591351 [ERK] *activation* by NECA or is unaffected by a tyrosine kinase inhibitor ( genistein ) , attenuated by a phospholipase C inhibitor ( U73122 ) , and is abolished by a MEK inhibitor ( PD098059 ) or dominant negative Ras . Positive_regulation EPHB2 UTP15 10026223 591357 Inhibition of protein kinase C ( PKC ) by GF 109203X failed to block ERK activation by NECA or UTP , however , another PKC inhibitor , Ro 31-8220 , which unlike GF 109203X , can block the zeta-isoform , and prevents but not NECA *induced* [ERK] activation . Positive_regulation EPHB2 UTP15 10026223 591363 In the presence of forskolin , Ro 31-8220 loses its ability to block *stimulated* [ERK] activation . Positive_regulation EPHB2 UTP15 16914897 1602396 ATP , 2-meSATP , and UDP *cause* a rapid and transitory increase in the phosphorylation of [MAPK/ERK] . Positive_regulation EPHB2 UTP15 17130674 1661364 PD98059 , a MEK ( mitogen activated protein kinase kinase ) inhibitor , and BAPTA-AM [ O , O'-bis ( 2-aminophenyl ) ethyleneglycol-N , N,N ' , N'-tetraacetic acid , tetraacetoxymethyl ester ] , an intracellular Ca ( 2+ ) chelator , reduced *induced* [ERK] phosphorylation and IL-6 mRNA expression . Positive_regulation EPHB2 UTP15 17130674 1661402 However , AG1478 , an epidermal growth factor (EGF)-receptor inhibitor , partially decreased *induced* [ERK] phosphorylation and IL-6 expression . Positive_regulation EPHB2 UTP15 18404517 1497318 Consistent with opposing effects of P2Y and P2X receptors on mitogenesis , *stimulated* a transient activation of [ERK] whereas BzATP stimulated a more sustained ERK signal . Positive_regulation EPHB2 UTP18 10026223 591349 [ERK] *activation* by NECA or is unaffected by a tyrosine kinase inhibitor ( genistein ) , attenuated by a phospholipase C inhibitor ( U73122 ) , and is abolished by a MEK inhibitor ( PD098059 ) or dominant negative Ras . Positive_regulation EPHB2 UTP18 10026223 591355 Inhibition of protein kinase C ( PKC ) by GF 109203X failed to block [ERK] *activation* by NECA or , however , another PKC inhibitor , Ro 31-8220 , which unlike GF 109203X , can block the zeta-isoform , and prevents UTP- but not NECA induced ERK activation . Positive_regulation EPHB2 UTP18 10026223 591361 In the presence of forskolin , Ro 31-8220 loses its ability to block *stimulated* [ERK] activation . Positive_regulation EPHB2 UTP18 16914897 1602394 ATP , 2-meSATP , and UDP *cause* a rapid and transitory increase in the phosphorylation of [MAPK/ERK] . Positive_regulation EPHB2 UTP18 17130674 1661362 PD98059 , a MEK ( mitogen activated protein kinase kinase ) inhibitor , and BAPTA-AM [ O , O'-bis ( 2-aminophenyl ) ethyleneglycol-N , N,N ' , N'-tetraacetic acid , tetraacetoxymethyl ester ] , an intracellular Ca ( 2+ ) chelator , reduced *induced* [ERK] phosphorylation and IL-6 mRNA expression . Positive_regulation EPHB2 UTP18 17130674 1661400 However , AG1478 , an epidermal growth factor (EGF)-receptor inhibitor , partially decreased *induced* [ERK] phosphorylation and IL-6 expression . Positive_regulation EPHB2 UTP18 18404517 1497316 Consistent with opposing effects of P2Y and P2X receptors on mitogenesis , *stimulated* a transient activation of [ERK] whereas BzATP stimulated a more sustained ERK signal . Positive_regulation EPHB2 UTP20 10026223 591347 [ERK] *activation* by NECA or is unaffected by a tyrosine kinase inhibitor ( genistein ) , attenuated by a phospholipase C inhibitor ( U73122 ) , and is abolished by a MEK inhibitor ( PD098059 ) or dominant negative Ras . Positive_regulation EPHB2 UTP20 10026223 591353 Inhibition of protein kinase C ( PKC ) by GF 109203X failed to block [ERK] *activation* by NECA or , however , another PKC inhibitor , Ro 31-8220 , which unlike GF 109203X , can block the zeta-isoform , and prevents UTP- but not NECA induced ERK activation . Positive_regulation EPHB2 UTP20 10026223 591359 In the presence of forskolin , Ro 31-8220 loses its ability to block *stimulated* [ERK] activation . Positive_regulation EPHB2 UTP20 16914897 1602392 ATP , 2-meSATP , and UDP *cause* a rapid and transitory increase in the phosphorylation of [MAPK/ERK] . Positive_regulation EPHB2 UTP20 17130674 1661360 PD98059 , a MEK ( mitogen activated protein kinase kinase ) inhibitor , and BAPTA-AM [ O , O'-bis ( 2-aminophenyl ) ethyleneglycol-N , N,N ' , N'-tetraacetic acid , tetraacetoxymethyl ester ] , an intracellular Ca ( 2+ ) chelator , reduced *induced* [ERK] phosphorylation and IL-6 mRNA expression . Positive_regulation EPHB2 UTP20 17130674 1661398 However , AG1478 , an epidermal growth factor (EGF)-receptor inhibitor , partially decreased *induced* [ERK] phosphorylation and IL-6 expression . Positive_regulation EPHB2 UTP20 18404517 1497314 Consistent with opposing effects of P2Y and P2X receptors on mitogenesis , *stimulated* a transient activation of [ERK] whereas BzATP stimulated a more sustained ERK signal . Positive_regulation EPHB2 UTP23 10026223 591352 [ERK] *activation* by NECA or is unaffected by a tyrosine kinase inhibitor ( genistein ) , attenuated by a phospholipase C inhibitor ( U73122 ) , and is abolished by a MEK inhibitor ( PD098059 ) or dominant negative Ras . Positive_regulation EPHB2 UTP23 10026223 591358 Inhibition of protein kinase C ( PKC ) by GF 109203X failed to block [ERK] *activation* by NECA or , however , another PKC inhibitor , Ro 31-8220 , which unlike GF 109203X , can block the zeta-isoform , and prevents UTP- but not NECA induced ERK activation . Positive_regulation EPHB2 UTP23 10026223 591364 In the presence of forskolin , Ro 31-8220 loses its ability to block *stimulated* [ERK] activation . Positive_regulation EPHB2 UTP23 16914897 1602397 ATP , 2-meSATP , and UDP *cause* a rapid and transitory increase in the phosphorylation of [MAPK/ERK] . Positive_regulation EPHB2 UTP23 17130674 1661365 PD98059 , a MEK ( mitogen activated protein kinase kinase ) inhibitor , and BAPTA-AM [ O , O'-bis ( 2-aminophenyl ) ethyleneglycol-N , N,N ' , N'-tetraacetic acid , tetraacetoxymethyl ester ] , an intracellular Ca ( 2+ ) chelator , reduced *induced* [ERK] phosphorylation and IL-6 mRNA expression . Positive_regulation EPHB2 UTP23 17130674 1661403 However , AG1478 , an epidermal growth factor (EGF)-receptor inhibitor , partially decreased *induced* [ERK] phosphorylation and IL-6 expression . Positive_regulation EPHB2 UTP23 18404517 1497319 Consistent with opposing effects of P2Y and P2X receptors on mitogenesis , *stimulated* a transient activation of [ERK] whereas BzATP stimulated a more sustained ERK signal . Positive_regulation EPHB2 UTP3 10026223 591350 [ERK] *activation* by NECA or is unaffected by a tyrosine kinase inhibitor ( genistein ) , attenuated by a phospholipase C inhibitor ( U73122 ) , and is abolished by a MEK inhibitor ( PD098059 ) or dominant negative Ras . Positive_regulation EPHB2 UTP3 10026223 591356 Inhibition of protein kinase C ( PKC ) by GF 109203X failed to block ERK activation by NECA or UTP , however , another PKC inhibitor , Ro 31-8220 , which unlike GF 109203X , can block the zeta-isoform , and prevents but not NECA *induced* [ERK] activation . Positive_regulation EPHB2 UTP3 10026223 591362 In the presence of forskolin , Ro 31-8220 loses its ability to block *stimulated* [ERK] activation . Positive_regulation EPHB2 UTP3 16914897 1602395 ATP , 2-meSATP , and UDP *cause* a rapid and transitory increase in the phosphorylation of [MAPK/ERK] . Positive_regulation EPHB2 UTP3 17130674 1661363 PD98059 , a MEK ( mitogen activated protein kinase kinase ) inhibitor , and BAPTA-AM [ O , O'-bis ( 2-aminophenyl ) ethyleneglycol-N , N,N ' , N'-tetraacetic acid , tetraacetoxymethyl ester ] , an intracellular Ca ( 2+ ) chelator , reduced *induced* [ERK] phosphorylation and IL-6 mRNA expression . Positive_regulation EPHB2 UTP3 17130674 1661401 However , AG1478 , an epidermal growth factor (EGF)-receptor inhibitor , partially decreased *induced* [ERK] phosphorylation and IL-6 expression . Positive_regulation EPHB2 UTP3 18404517 1497317 Consistent with opposing effects of P2Y and P2X receptors on mitogenesis , *stimulated* a transient activation of [ERK] whereas BzATP stimulated a more sustained ERK signal . Positive_regulation EPHB2 UTP6 10026223 591348 [ERK] *activation* by NECA or is unaffected by a tyrosine kinase inhibitor ( genistein ) , attenuated by a phospholipase C inhibitor ( U73122 ) , and is abolished by a MEK inhibitor ( PD098059 ) or dominant negative Ras . Positive_regulation EPHB2 UTP6 10026223 591354 Inhibition of protein kinase C ( PKC ) by GF 109203X failed to block ERK activation by NECA or UTP , however , another PKC inhibitor , Ro 31-8220 , which unlike GF 109203X , can block the zeta-isoform , and prevents but not NECA *induced* [ERK] activation . Positive_regulation EPHB2 UTP6 10026223 591360 In the presence of forskolin , Ro 31-8220 loses its ability to block *stimulated* [ERK] activation . Positive_regulation EPHB2 UTP6 16914897 1602393 ATP , 2-meSATP , and UDP *cause* a rapid and transitory increase in the phosphorylation of [MAPK/ERK] . Positive_regulation EPHB2 UTP6 17130674 1661361 PD98059 , a MEK ( mitogen activated protein kinase kinase ) inhibitor , and BAPTA-AM [ O , O'-bis ( 2-aminophenyl ) ethyleneglycol-N , N,N ' , N'-tetraacetic acid , tetraacetoxymethyl ester ] , an intracellular Ca ( 2+ ) chelator , reduced *induced* [ERK] phosphorylation and IL-6 mRNA expression . Positive_regulation EPHB2 UTP6 17130674 1661399 However , AG1478 , an epidermal growth factor (EGF)-receptor inhibitor , partially decreased *induced* [ERK] phosphorylation and IL-6 expression . Positive_regulation EPHB2 UTP6 18404517 1497315 Consistent with opposing effects of P2Y and P2X receptors on mitogenesis , *stimulated* a transient activation of [ERK] whereas BzATP stimulated a more sustained ERK signal . Positive_regulation EPHB2 UTS2 11707268 879518 [ERK] *activation* by at 100 nM peaked at 8 min after stimulation . Positive_regulation EPHB2 UTS2 12495783 1033481 On the other hand , *induced* an increase in the phosphorylation level of [ERK] , but not FAK , in cells adherent to fibronectin . Positive_regulation EPHB2 UTS2 12495783 1033482 Our results suggested that activation of integrin mediated signaling pathways play a critical role in *induced* phosphorylation of [ERK] , leading to proliferation of VSMCs , which does not involved increased phosphorylation of FAK . Positive_regulation EPHB2 UTS2 16896801 1601128 Stress-fiber formation and [ERK] ( p44/p42 ) activity were also *increased* by . Positive_regulation EPHB2 VAV1 10898494 712070 The MEK inhibitor PD90859 inhibited *induced* activation of [ERK] , and Vav- or anti-CD3 induced activation of NFAT , suggesting that MEK and ERK are involved in Vav mediated NFAT activation . Positive_regulation EPHB2 VAV1 16709244 1589881 In contrast , mutations in the SH2 and C-SH3 domains did not affect Rac activation by Vav1Y3F , but reduced the ability of to *induce* EGF independent migration and constitutive [ERK] phosphorylation . Positive_regulation EPHB2 VAV1 16709244 1589885 Lastly , treatment of cells with the EGF receptor inhibitory antibody blocked the *induced* , EGF independent stimulation of [ERK] phosphorylation , but had no effect on Rac1 activation or PAK phosphorylation . Positive_regulation EPHB2 VAV1 17119112 1700615 Although RhoH is not required for TCR induced activation of ZAP70 and ZAP70 mediated activation of p38 , it is crucial for the tyrosine phosphorylation of LAT , PLCgamma1 , and and for the *activation* of [Erk] and calcium influx . Positive_regulation EPHB2 VAV2 20140013 2242298 In this work , we show that expression delayed epidermal growth factor receptor (EGFR) internalization and degradation , and *enhanced* EGFR , [ERK] and Akt phosphorylations . Positive_regulation EPHB2 VCL 24466349 2907864 and Rab5 were *involved* in the S. aureus induced phosphorylation of MAP kinases ( p38 , [Erk] , and JNK ) and IL-6 expression . Positive_regulation EPHB2 VCP 10648884 662338 depolarization induced calcium *increases* activated both [ERK] and p38 kinase within 5 min . Positive_regulation EPHB2 VDR 22878203 2671751 Thus might not be *involved* in [ERK] phosphorylation by vitamin D ( 3 ) . Positive_regulation EPHB2 VEGFA 10050071 592992 We demonstrate that angiostatin diminishes [ERK] *activation* by basic fibroblast growth factor and . Positive_regulation EPHB2 VEGFA 11171046 783703 Neither activation nor inhibition of the NO/cGMP pathway had any effect on *induction* of [ERK] activity and PGI ( 2 ) synthesis . Positive_regulation EPHB2 VEGFA 11171046 783709 Wortmannin partially inhibited VEGF stimulation of PGI ( 2 ) production , but did not inhibit *induced* [ERK] activity . Positive_regulation EPHB2 VEGFA 11171046 783711 VEGF induced [ERK] activation and PGI ( 2 ) production were blocked by rottlerin , and *increased* association of PKCdelta with Raf-1 , the upstream activator of MEK . Positive_regulation EPHB2 VEGFA 11322784 807192 We identified 12-amino acid peptides derived from exon 6 that inhibited VEGF binding to HUVECs , *stimulated* [ERK] activation , and prostacyclin production . Positive_regulation EPHB2 VEGFA 11327725 807658 Cysteine-rich and basic Tat peptides inhibited *induced* [ERK] activation and mitogenesis in endothelial cells , and inhibited angiogenesis in vitro at concentrations similar to those which inhibited VEGF receptor binding . Positive_regulation EPHB2 VEGFA 11332691 809086 In addition , premixing with heparin sulphate proteoglycan *potentiated* trophoblast proliferation and the association of [phospho-ERK] with the VEGFR-2 receptor . Positive_regulation EPHB2 VEGFA 11424087 831151 ( VEGF ) *activates* [ERK] and p38 MAPK in endothelial cells ( ECs ) . Positive_regulation EPHB2 VEGFA 11424087 831165 *activated* [ERK] and p38 MAPK in all of three ECs . Positive_regulation EPHB2 VEGFA 11424087 831192 GF109203X , a specific inhibitor of PKC , markedly inhibited *induced* activation of [ERK] and p38 MAPK in HAECs and HUVECs , whereas it exhibited little effect in HMVECs . Positive_regulation EPHB2 VEGFA 11424087 831206 In contrast , dominant negative mutant of Ha-Ras almost completely abrogated *induced* activation of [ERK] and p38 MAPK in HMVECs . Positive_regulation EPHB2 VEGFA 11424087 831247 Although dominant negative mutant of Ha-Ras substantially inhibited the basal activities of ERK and p38 MAPK , it exhibited marginal effect on *induced* activation of [ERK] and p38 MAPK in HUVECs and HAECs . Positive_regulation EPHB2 VEGFA 11527089 853289 Both IGF-I and produced a time- and concentration dependent *increase* in the activation of [ERK] . Positive_regulation EPHB2 VEGFA 11719508 904169 Moreover , catalase , the lipoxygenase inhibitor nordihydroguaiaretic acid , the synthetic ROS scavenger EUK-134 , and phosphatidylinositol 3-kinase inhibitor wortmannin all reduce [ERK] phosphorylation in *response* to , and antioxidants prevent VEGF dependent mitogenesis . Positive_regulation EPHB2 VEGFA 12029087 968120 Endostatin blocked induced tyrosine phosphorylation of KDR/Flk-1 and *activation* of [ERK] , p38 MAPK , and p125(FAK) in human umbilical vein endothelial cells . Positive_regulation EPHB2 VEGFA 12391145 1001662 Small interfering RNA ( siRNA ) that targets SPK1 , but not SPK2 , blocks *induced* accumulation of Ras-GTP and [phospho-ERK] in T24 cells . Positive_regulation EPHB2 VEGFA 12529448 1048806 Removal of caveolin and VEGFR-2 from caveolae by cholesterol depletion resulted in an increase in both basal and VEGF induced phosphorylation of VEGFR-2 , but led to the inhibition of *induced* [ERK] activation and endothelial cell migration , suggesting that localization of VEGFR-2 to these domains is crucial for VEGF mediated signaling . Positive_regulation EPHB2 VEGFA 12637990 1068683 Interestingly , *mediated* phosphorylation of [ERK] was significantly attenuated by HGF/NK4 . Positive_regulation EPHB2 VEGFA 12680875 1077310 Since the intracellular signalling of SDF-1 induced neovascularization remains unclear , we studied in human umbilical arterial endothelial cells ( HUAEC ) the influence of SDF-1alpha on induction of the genes of early growth response-1 (Egr-1) and , as well as the *activation* of [extracellular regulated kinases (ERK)] 1/2 , which are all known to be involved in endothelial cell proliferation . Positive_regulation EPHB2 VEGFA 12711339 1083284 The results showed a transient mediated [ERK] *activation* that peaked at 10min , which was consistent with previous reports using conventional techniques . Positive_regulation EPHB2 VEGFA 12893832 1142985 *potentiated* TRANCE induced [ERK] activation and tube formation via RANK up-regulation in HUVECs . Positive_regulation EPHB2 VEGFA 14633511 1201162 In addition , stimulation of ASM with *activates* [ERK] , but not p38MAPK , and fibronectin secretion is ERK dependent . Positive_regulation EPHB2 VEGFA 14704231 1225410 Localization of VEGFR-2 and PLD2 in endothelial caveolae is involved in *induced* phosphorylation of MEK and [ERK] . Positive_regulation EPHB2 VEGFA 14704231 1225456 A PLD inhibitor , 1-butanol , almost completely suppressed *induced* [ERK] phosphorylation and cellular proliferation , whereas the negative control for 1-butanol , 3-butanol , did not produce significant changes . Positive_regulation EPHB2 VEGFA 14704231 1225467 Pharmacological analyses using several inhibitors indicated that PKC-delta regulates the *induced* activation of [PLD/ERK] . Positive_regulation EPHB2 VEGFA 15205364 1273880 Interestingly , caveolin transfection in Cav-/- ECs redirected the VEGFR-2 in caveolar membranes and restored the *induced* [ERK] and eNOS activation . Positive_regulation EPHB2 VEGFA 15541367 1336917 Activation and translocation of PKCdelta is necessary for *induced* [ERK] activation through KDR in HEK293T cells . Positive_regulation EPHB2 VEGFA 15541367 1336919 PKC specific inhibitors and human PKCdelta knock-down using siRNA method showed that PKCdelta played an important role in *induced* [ERK] activation . Positive_regulation EPHB2 VEGFA 15541367 1336924 stimulation did not *induce* [ERK] phosphorylation in human PKCdelta-knockdown HEK293T cells , but co-expression of rat PKCdelta-GFP recovered the ERK phosphorylation . Positive_regulation EPHB2 VEGFA 15541367 1336927 These results indicate that PKCdelta is involved in *induced* [ERK] activation via C1B domain . Positive_regulation EPHB2 VEGFA 15579907 1361381 Binding of T2-TrpRS inhibited *induced* [ERK] activation and EC migration . Positive_regulation EPHB2 VEGFA 15919658 1433644 *stimulated* [Erk] phosphorylation that was required for induction of protein synthesis . Positive_regulation EPHB2 VEGFA 15919658 1433648 *induced* [Erk] activation was not dependent on phosphoinositide (PI) 3-kinase activation but required sequential phosphorylation of type 2 VEGF receptor , PLCgamma and c-Src , as demonstrated by inhibitors SU1498 , U73122 , and PP1 , respectively . Positive_regulation EPHB2 VEGFA 16242916 1532021 Using two PKC inhibitors has demonstrated that concomitantly *stimulates* IKK and its negative regulatory signal [ERK] through PKC that lies downstream of KDR/Flk-1 . Positive_regulation EPHB2 VEGFA 16328781 1511919 Hyperbaric oxygen *induces* expression through [ERK] , JNK and c-Jun/AP-1 activation in human umbilical vein endothelial cells . Positive_regulation EPHB2 VEGFA 16331603 1526292 In vitro , PCK3145 specifically antagonized in a dose dependent manner the *induced* [ERK] phosphorylation as well as the phosphorylation of the VEGFR-2 in cultured EC ( HUVEC ) . Positive_regulation EPHB2 VEGFA 16842782 1591557 Exposure of HUVECs to LF significantly increased *induced* [ERK] MAP kinase phosphorylation . Positive_regulation EPHB2 VEGFA 17008606 1629033 Herein we report that VEGF binds to the heparin-II domain of Fn and that the cell binding and VEGF binding domains of Fn , when physically linked , are necessary and sufficient to promote induced endothelial cell proliferation , migration , and [Erk] *activation* . Positive_regulation EPHB2 VEGFA 17015762 1629925 rapidly *triggered* phospho-Akt and [phospho-ERK] activity and then induced Bcl-2 expression in the rheumatoid synoviocytes . Positive_regulation EPHB2 VEGFA 17027148 1700272 To determine the basis of these observations , we examined the expression of and *activation* of JNK and [ERK] in A549 cells exposed to LGD1069 . Positive_regulation EPHB2 VEGFA 17438136 1742795 In cultured cells , the overexpression of Spred-1 or Spred-2 strongly suppressed vascular endothelial growth factor-C ( VEGF-C ) *mediated* [ERK] activation , while Spred-1/2-deficient cells were extremely sensitive to VEGFR-3 signaling . Positive_regulation EPHB2 VEGFA 17496149 1744428 SU1498 ( a specific inhibitor of Flk-1 ) and Nck beta ( nm ) ( a negative mutant of Nck beta ) blocked the *induced* [ERK] and JNK activities . Positive_regulation EPHB2 VEGFA 17566084 1798055 We have found that VS-1 ( 3 microg/ml ; 330 nM ) can inhibit *induced* [ERK] phosphorylation , as well as cell migration , proliferation , morphogenesis , and invasion of collagen gels in various in vitro assays . Positive_regulation EPHB2 VEGFA 17614789 1848522 The sFlt-1 protein blocked *induced* [ERK] ( extracellular-signal regulated kinase ) phosphorylation and inhibited the MAPK ( mitogen activated protein kinase ) signalling cascades . Positive_regulation EPHB2 VEGFA 17644065 1775715 Endostar suppressed the *induced* tyrosine phosphorylation of KDR/Flk-1 ( VEGFR-2 ) as well as the overall VEGFR-2 expression and the activation of [ERK] , p38 MAPK , and AKT in HUVECs . Positive_regulation EPHB2 VEGFA 17961496 1826475 It inhibited *induced* activation of AKT and [ERK] signaling and reduced hypoxia enhanced HepG2 cell survivability . Positive_regulation EPHB2 VEGFA 18266967 2000289 induced *activation* of p42 [MAPK/ERK] also led to the nuclear translocation of MAPK/ERK1/2 . Positive_regulation EPHB2 VEGFA 18267956 1891143 Adiponectin also suppressed *induced* reactive oxygen species generation , activation of Akt , the mitogen activated protein kinase [ERK] and the RhoGTPase RhoA , and induction of the formation of actin stress fibres and focal cellular adhesions . Positive_regulation EPHB2 VEGFA 18307536 1885934 Our studies suggest that IL-8 might be a malignant factor in human pancreatic cancer by induction of and NRP-2 expression and [ERK] *activation* . Positive_regulation EPHB2 VEGFA 18323518 1897630 By regulating VEGFR2 expression and activation , PKC-epsilon expression is critical for activation of Akt and eNOS by VEGF and contributes to *stimulated* [Erk] activation , whereas PKC-alpha has opposite effects . Positive_regulation EPHB2 VEGFA 18816248 2012425 Although ( 165 ) also *activates* [ERK] ( extracellular-signal regulated kinase ) -1/2 , this is not necessary for eNOS activation since U0126 blocks ERK-1/2 phosphorylation , but not eNOS activation , and the VEGFR-2 kinase inhibitor inhibits eNOS activation , but not ERK-1/2 phosphorylation . Positive_regulation EPHB2 VEGFA 18818406 1976504 Interestingly , an ADAM17-selective inhibitor shortens the duration of *stimulated* [ERK] phosphorylation in human umbilical vein endothelial cells , providing evidence for an ADAM17 dependent crosstalk between the VEGFR2 and ERK signaling . Positive_regulation EPHB2 VEGFA 18987025 1989804 Furthermore , miR-126 deletion inhibited *dependent* Akt and [Erk] signaling by derepression of the p85beta subunit of PI3 kinase and of Spred1 , respectively . Positive_regulation EPHB2 VEGFA 19001434 1991096 Importantly , besides blocking *induced* [Erk] and SAPK phosphorylation in endothelial cells , the Raf inhibitor diminished STAT3 phosphorylation , independent of a VEGFR2 blockade , and reduced the expression of survivin . Positive_regulation EPHB2 VEGFA 19137008 2037751 It has been shown that mediated [ERK] *activation* is strongly dependent on protein kinase C ( PKC ) , whereas that by VEGF-C is dependent on Ras . Positive_regulation EPHB2 VEGFA 19265684 2055564 Furthermore , *induced* [ERK] phosphorylation was stimulated by CCL23 . Positive_regulation EPHB2 VEGFA 19385062 2069350 The exchange protein directly activated by cAMP ( Epac ) activator , 8CPT-2Me-cAMP , promoted the Akt/eNOS/NO pathway and [ERK] phosphorylation , but did not *induce* CREB phosphorylation and expression . Positive_regulation EPHB2 VEGFA 20008289 2191239 Cutting edge : mediated signaling in human CD45RO+ CD4+ T cells *promotes* Akt and [ERK] activation and costimulates IFN-gamma production . Positive_regulation EPHB2 VEGFA 20008289 2191243 Furthermore , by Western blot analysis , we find that *increases* the phosphorylation and activation of [ERK] and Akt within CD4+CD45RO+ T cells . Positive_regulation EPHB2 VEGFA 20395410 2287872 *induced* [ERK] and AKT phosphorylation ( indicative of differentiation ) , while inhibiting phosphorylation of STAT3 ( indicative of ` stemness ' ) . Positive_regulation EPHB2 VEGFA 20472758 2294587 We also determined that XIAP is critical to shear stress stimulated ERK activation in an alpha ( 5 ) -integrin dependent manner but is not important to *induced* [ERK] activation . Positive_regulation EPHB2 VEGFA 20538685 2295648 Stimulation of HSB-2 and T cells with *triggered* downstream [ERK] phosphorylation , demonstrating the functionality of VEGFR-1 in human T cells . Positive_regulation EPHB2 VEGFA 20718746 2306753 We showed that dorsomorphin , similar to the VEGF inhibitor SU5416 , strongly inhibits intersegmental vessel formation in zebrafish and that this is due to inhibition of VEGF activation of VEGF receptor 2 (VEGFR2) , leading to reduced *induced* [phospho-ERK] ( extracellular regulated kinase ) 1/2 and VEGF target gene transcription . Positive_regulation EPHB2 VEGFA 21507243 2428585 Inhibition of eNOS abrogated VEGF mediated proliferation and migration , but was without effect on *stimulated* fatty acid transport , [ERK] or Akt phosphorylation . Positive_regulation EPHB2 VEGFA 21633982 2538670 The PRE significantly suppressed *induced* tube formation , proliferation and migration in HUVECs and HRMECs as well as phosphorylation of [ERK] and p38 . Positive_regulation EPHB2 VEGFA 21781996 2500348 reversed the inhibition of phosphoinositide 3-kinase (PI3-K)/Akt pathway caused by MPP ( + ) , but further *enhanced* the activation of [ERK] induced by MPP ( + ) . Positive_regulation EPHB2 VEGFA 21801813 2505340 VEGF up-regulates the activity of ERK ( extracellular signal regulated kinase ) in cultured cortical neurons and U0126 ( a mitogen activated protein kinase kinase ( MEK ) inhibitor ) suppressed *induced* activity of [ERK] . Positive_regulation EPHB2 VEGFA 21803847 2484749 We also demonstrated that *dependent* [ERK] phosphorylation required integrity of caveolae as well as caveolar uPAR expression . Positive_regulation EPHB2 VEGFA 22539090 2726271 In vivo , treatment with bevacizumab inhibited growth of xenografted tumors and attenuated *induced* phosphorylation of Akt and [ERK] . Positive_regulation EPHB2 VEGFA 22659165 2620398 *induces* proliferation of human hair follicle dermal papilla cells through VEGFR-2 mediated activation of [ERK] . Positive_regulation EPHB2 VEGFA 23352833 2758502 On the other hand , phosphorylation of [ERK] *induced* by and MCP-1 was inhibited by PF-4 , Mig and IP-10 . Positive_regulation EPHB2 VEGFA 23393131 2764423 Silencing of ECSCR disrupts *induced* KDR activation and AKT and [ERK] phosphorylation and impairs VEGF stimulated KDR degradation . Positive_regulation EPHB2 VEGFA 23784812 2849182 Glyceollin treatment suppressed activation of Akt , [Erk] , and eNOS *induced* by SDF-1a or ( VEGF ) . Positive_regulation EPHB2 VEGFA 24018888 2837260 In addition , blocking vascular endothelial growth factor ( VEGF ) in CREG overexpressed HUVEC and supplementation of VEGF in CREG knocked-down HUVEC identified that the pro-proliferative effect of CREG was partially mediated by *induced* [ERK/cyclin] E activation . Positive_regulation EPHB2 VEGFA 24096161 2896341 Our further study showed that cardamonin decreased the phosphorylation of [ERK] and AKT *induced* by with a dose dependent manner in HUVECs . Positive_regulation EPHB2 VEGFA 24200956 2891729 Lung monocyte VEGF-A expression and microvascular Akt and [ERK] activation were also found in vivo after CBDL , and *activated* Akt and ERK and angiogenesis in rat pulmonary microvascular endothelial cells in vitro . Positive_regulation EPHB2 VEGFA 24220315 2916540 and ICPP *induced* [ERK] phosphorylation in the myocardium . Positive_regulation EPHB2 VEGFA 9393975 468023 Inhibiting the induced *activation* of [ERK] with PD098059 did not influence actin organization or cell migration but totally inhibited the VEGF induced incorporation of thymidine into DNA . Positive_regulation EPHB2 VEGFC 19137008 2037750 Sprouty4 inhibits vascular endothelial growth factor ( VEGF ) -A-induced [ERK] activation , but not induced ERK *activation* . Positive_regulation EPHB2 VEGFC 24464750 2923250 Furthermore , *activated* the TGF-ß1 pathway and [ERK] phosphorylation , which was significantly suppressed by TGF-ß or ERK blockade . Positive_regulation EPHB2 VIM 17251187 1710296 Independently , depletion of by small hairpin RNA ( shRNA ) completely *inhibited* beta3AR mediated [ERK] activation and significantly reduced lipolysis . Positive_regulation EPHB2 VIM 20088823 2218952 Taken together , the present studies suggest that a dynamic and function related interaction between IbeA and its primary receptor at HBMEC membrane rafts *leads* to vimentin phosphorylation and [ERK] mediated signalling , which modulate meningitic E. coli K1 invasion . Positive_regulation EPHB2 VIP 10940738 721084 [ERK] *activation* by or PACAP38 and TRH were additive and both sensitive to the MEK inhibitors PD98059 and U0126 . Positive_regulation EPHB2 VIP 10940738 721087 These results demonstrate for the first time that and PACAP38 *activate* [ERK] in GH4C1 cells . Positive_regulation EPHB2 VIP 12747941 1088889 Under serum-free conditions stimulates HT29 cell proliferation and *induced* a time- and concentration dependent [ERK] activation . Positive_regulation EPHB2 VIP 14551200 1175538 Experiments involving the expression of the dominant negative mutants of Ras and Rap1 signaling ( RasN17 or Rap1N17 ) indicate that both GTPases Ras and Rap1 are recruited for the [ERK] *activation* by and PACAP38 , whereas Rap1 is poorly involved in TRH or EGF induced ERK activation . Positive_regulation EPHB2 VIP 18174366 1883377 interaction *results* in cAMP independent [PI-3K/ERK] activation with downstream integrin up-regulation . Positive_regulation EPHB2 VIP 21815197 2495469 In addition , robustly *enhanced* the phosphorylation of [ERK] and the stimulatory effect by VIP on rankl mRNA was inhibited by the MEK1/2 inhibitor PD98059 . Positive_regulation EPHB2 WAS 11553284 857115 However , blockade of dopaminergic (DA) D1 receptors by administration of SCH 23390 , prior to THC , totally prevents ERK activation in the striatum , thus demonstrating a critical involvement of DA systems in *induced* [ERK] activation . Positive_regulation EPHB2 WAS 11553284 857116 DA-D2 and glutamate receptors of NMDA subtypes also participate , albeit to a lesser extent , to *induced* [ERK] activation in the striatum , as shown after injection of selective antagonists ( raclopride and MK801 , respectively ) . Positive_regulation EPHB2 WAS 12657697 1073292 In living mice , *activated* [ERK] in hippocampal neurons and induced its accumulation in the nuclei of pyramidal cells in CA1 and CA3 . Positive_regulation EPHB2 WAS 16337472 1491335 These results suggest that is *essential* for NF-ATp activation , and for nuclear translocation of [p-Erk] , Elk1 phosphorylation , and c-fos gene expression in T cells . Positive_regulation EPHB2 WAS 16954596 1611064 As a whole , our data suggest that in the striatum and cerebellum , *induced* [ERK] activation could represent a key signaling event to initiate homologous desensitization of CB1 receptor , accounting for the development of tolerance to THC induced hypolocomotion . Positive_regulation EPHB2 WDR61 11934880 953472 In contrast , these inhibitors almost completely blocked both *induced* [ERK] phosphorylation and LTC ( 4 ) generation in PAFR cells . Positive_regulation EPHB2 WDR61 11934880 953477 However , in mPAFR cells pertussis toxin only partially inhibited *induced* [ERK] phosphorylation . Positive_regulation EPHB2 WDR61 11934880 953482 A Ca ( 2+ ) /calmodulin inhibitor had no effect on *induced* [ERK] phosphorylation in PAFR cells but completely blocked the response in mPAFR cells . Positive_regulation EPHB2 WDR61 12687020 1078715 *activated* three prominent mitogen activated protein kinase modules ( [ERK] , p38MAPK and Jun N-terminal kinases ) in these cells , inhibited proliferation and induced differentiation ( measured by the induction of Waf1/p21 and the induction of the differentiation related marker CEA ) . Positive_regulation EPHB2 WDR61 15115659 1241553 These results indicate that induced *activation* of [ERK] contributes to both the expression of the pro-adhesive phenotype and repression of neutrophil apoptosis , thereby amplifying the inflammatory response . Positive_regulation EPHB2 WDR61 15917990 1413203 *induced* [ERK] phosphorylation is mediated by PI3K , PKC , PLA2 , PLC , and extracellular calcium , whereas fMLP induced ERK phosphorylation does not involve the PKC-gamma isoform and extracellular calcium . Positive_regulation EPHB2 WDR61 20074623 2218625 These results suggest that *induces* synaptic facilitation through activation of CaMKII , PKC and [ERK] in the hippocampal CA1 region . Positive_regulation EPHB2 WDR61 23911909 2840517 Likewise , ERK phosphorylation was markedly enhanced in PAF stimulated VSMCs , and this was attenuated by WEB2086 , but not by EGF receptor inhibitor , demonstrating the specificity of PAF receptor (PAFR) in *induced* [ERK] phosphorylation . Positive_regulation EPHB2 WDR61 23911909 2840523 In addition , *induced* [ERK] phosphorylation and MMP-2 production were significantly attenuated by ß-arrestin2 depletion . Positive_regulation EPHB2 WDR61 9878562 557852 Stimulation of receptor *induces* activation of extracellular signal regulated kinase ( [ERK] ) and cytosolic phospholipase A2 (cPLA2) and release of arachidonic acid in Chinese hamster ovary cells . Positive_regulation EPHB2 WDR61 9915820 587191 The *induced* p38 and [ERK] pathways appeared to be preferentially regulated by RGS16 and RGS1 , respectively . Positive_regulation EPHB2 WDR83 15118098 1244595 Suppression of by short interfering RNA *leads* to a marked reduction in [ERK] activity when cells are stimulated with serum . Positive_regulation EPHB2 WISP2 21723256 2461169 These results suggested that secreted *induces* Akt and [ERK] phosphorylation via integrins , and consequently facilitates neurite formation and conferred resistance to apoptosis . Positive_regulation EPHB2 WNK1 24345501 2880889 TNF-a stimulated significantly phosphorylation on Ser536 of , Ser473 of Akt at 5-15 min , and *activations* of IKK-ß and [ERK] at 15-30 min. Diosgenin ( 1 µmol · Positive_regulation EPHB2 WNT1 15615777 1361950 Therefore , [ERK] pathway *activation* by signaling could occur at multiple levels , including beta-catenin independent direct signaling resulting from a Wnt3a and beta-catenin/Tcf-4 dependent post gene transcriptional event . Positive_regulation EPHB2 WNT1 22385658 2566499 The switch in Smad2 ,3 activity after inactivation of PI3K/Akt requires the *activation* of canonical signaling by [Erk] , which targets Gsk3ß . Positive_regulation EPHB2 WNT1 24877628 2951223 Together , we report that Lgr4 modulates *mediated* [EGFR-ERK] signaling to facilitate corpus luteum maturation and ovarian steroidogenesis to maintain female reproduction . Positive_regulation EPHB2 WNT11 15615777 1361951 Therefore , [ERK] pathway *activation* by signaling could occur at multiple levels , including beta-catenin independent direct signaling resulting from a Wnt3a and beta-catenin/Tcf-4 dependent post gene transcriptional event . Positive_regulation EPHB2 WNT11 22385658 2566500 The switch in Smad2 ,3 activity after inactivation of PI3K/Akt requires the *activation* of canonical signaling by [Erk] , which targets Gsk3ß . Positive_regulation EPHB2 WNT11 24877628 2951224 Together , we report that Lgr4 modulates *mediated* [EGFR-ERK] signaling to facilitate corpus luteum maturation and ovarian steroidogenesis to maintain female reproduction . Positive_regulation EPHB2 WNT16 15615777 1361956 Therefore , [ERK] pathway *activation* by signaling could occur at multiple levels , including beta-catenin independent direct signaling resulting from a Wnt3a and beta-catenin/Tcf-4 dependent post gene transcriptional event . Positive_regulation EPHB2 WNT16 22385658 2566505 The switch in Smad2 ,3 activity after inactivation of PI3K/Akt requires the *activation* of canonical signaling by [Erk] , which targets Gsk3ß . Positive_regulation EPHB2 WNT16 24877628 2951229 Together , we report that Lgr4 modulates *mediated* [EGFR-ERK] signaling to facilitate corpus luteum maturation and ovarian steroidogenesis to maintain female reproduction . Positive_regulation EPHB2 WNT2 15615777 1361952 Therefore , [ERK] pathway *activation* by signaling could occur at multiple levels , including beta-catenin independent direct signaling resulting from a Wnt3a and beta-catenin/Tcf-4 dependent post gene transcriptional event . Positive_regulation EPHB2 WNT2 22385658 2566501 The switch in Smad2 ,3 activity after inactivation of PI3K/Akt requires the *activation* of canonical signaling by [Erk] , which targets Gsk3ß . Positive_regulation EPHB2 WNT2 24877628 2951225 Together , we report that Lgr4 modulates *mediated* [EGFR-ERK] signaling to facilitate corpus luteum maturation and ovarian steroidogenesis to maintain female reproduction . Positive_regulation EPHB2 WNT3 15615777 1361953 Therefore , [ERK] pathway *activation* by signaling could occur at multiple levels , including beta-catenin independent direct signaling resulting from a Wnt3a and beta-catenin/Tcf-4 dependent post gene transcriptional event . Positive_regulation EPHB2 WNT3 22385658 2566502 The switch in Smad2 ,3 activity after inactivation of PI3K/Akt requires the *activation* of canonical signaling by [Erk] , which targets Gsk3ß . Positive_regulation EPHB2 WNT3 24877628 2951226 Together , we report that Lgr4 modulates *mediated* [EGFR-ERK] signaling to facilitate corpus luteum maturation and ovarian steroidogenesis to maintain female reproduction . Positive_regulation EPHB2 WNT3A 15615777 1361949 *induced* [ERK] activation was maintained even though basal ERK activities were reduced by beta-catenin siRNA , indicating that Wnt3a may activate the ERK pathway independently of beta-catenin . Positive_regulation EPHB2 WNT3A 17374561 1748326 The RAF-1 -- > MEK -- > ERK cascade was immediately increased by WNT3a treatment , however , the upstream event triggering [ERK] pathway *activation* by is not clear . Positive_regulation EPHB2 WNT3A 17374561 1748327 WNT3a activated RAS and *induced* [ERK] activation was blocked by dominant negative RAS , indicating that WNT3a might act upstream of RAS . Positive_regulation EPHB2 WNT3A 17374561 1748329 *induced* [ERK] pathway activations were blocked by AG1478 , the epidermal growth factor receptor (EGFR) inhibitor , and EGFR siRNA . Positive_regulation EPHB2 WNT3A 17374561 1748331 The *induced* [ERK] pathway activation was not observed in fibroblasts retaining defective EGFR , but the WNT3a effect was restored by EGFR reconstitution . Positive_regulation EPHB2 WNT3A 17374561 1748332 *induced* [ERK] pathway activation was not affected by Dickkoff-1 (DKK-1) , although WNT3a induced activations of the WNT/beta-catenin pathway and proliferation were reduced by DKK-1 . Positive_regulation EPHB2 WNT3A 17717053 1807510 Dickkopf 1 , a selective antagonist of Wnt proteins binding to low-density lipoprotein-receptor related protein-5/6 did not influence activation of p38 and [ERK] *induced* by . Positive_regulation EPHB2 WNT3A 17717053 1807513 In conclusion , *activates* [ERK] and p38 in mesenchymal C3H10T1/2 cells by a low-density lipoprotein-receptor related protein-5/6 independent mechanism . Positive_regulation EPHB2 WNT4 15615777 1361954 Therefore , [ERK] pathway *activation* by signaling could occur at multiple levels , including beta-catenin independent direct signaling resulting from a Wnt3a and beta-catenin/Tcf-4 dependent post gene transcriptional event . Positive_regulation EPHB2 WNT4 22385658 2566503 The switch in Smad2 ,3 activity after inactivation of PI3K/Akt requires the *activation* of canonical signaling by [Erk] , which targets Gsk3ß . Positive_regulation EPHB2 WNT4 24877628 2951227 Together , we report that Lgr4 modulates *mediated* [EGFR-ERK] signaling to facilitate corpus luteum maturation and ovarian steroidogenesis to maintain female reproduction . Positive_regulation EPHB2 WNT5A 21454669 2422334 mediated [ERK] *activation* in mesencephalic neuronal cultures was inhibited by treatment of D2R antagonist and EGFR inhibitors in WT mice . Positive_regulation EPHB2 WNT6 15615777 1361955 Therefore , [ERK] pathway *activation* by signaling could occur at multiple levels , including beta-catenin independent direct signaling resulting from a Wnt3a and beta-catenin/Tcf-4 dependent post gene transcriptional event . Positive_regulation EPHB2 WNT6 22385658 2566504 The switch in Smad2 ,3 activity after inactivation of PI3K/Akt requires the *activation* of canonical signaling by [Erk] , which targets Gsk3ß . Positive_regulation EPHB2 WNT6 24877628 2951228 Together , we report that Lgr4 modulates *mediated* [EGFR-ERK] signaling to facilitate corpus luteum maturation and ovarian steroidogenesis to maintain female reproduction . Positive_regulation EPHB2 XDH 11509539 848319 Direct exposure of VSM cells to increased superoxide levels by treatment with xanthine/xanthine oxidase increased ERK activation and MMP-9 induction , whereas pretreatment of cells with PD-98059 significantly ( P < 0.05 ) inhibited *stimulated* [ERK] activation and MMP-9 induction . Positive_regulation EPHB2 XIAP 20236757 2272847 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2 , Bcl-xL and ) , as well as *activation* of [Ras/MEK/ERK] and PI3K/Akt signaling . Positive_regulation EPHB2 XIAP 21742513 2484183 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-8 is associated with increased expression of both multidrug resistance related genes ( MDR1 ) and apoptosis inhibitory proteins ( Bcl-2 , Bcl-xL , and ) , as well as *activation* of PI3K/Akt and [Ras/MEK/ERK] signaling . Positive_regulation EPHB2 XRCC5 11146560 760887 We provide evidence that mutants *promote* [ERK] activation and that the active protein induces a more sustained activation than the inactive protein . Positive_regulation EPHB2 XRCC5 11228165 788432 is *involved* in cell stretching modulation of p38 but not [ERK] or JNK MAP kinase . Positive_regulation EPHB2 XRCC5 11479306 860639 Moreover , inhibition of by a Rap1 GTPase activating protein-1 also *resulted* in a decrease in [ERK] and Akt phosphorylation , which was not further decreased by cAMP , suggesting that cAMP inhibits ERK and Akt by inhibiting Rap1 . Positive_regulation EPHB2 XRCC5 11479306 860695 The *role* of in [ERK] and Akt activity was further demonstrated by our observation that an active form of Epac , which activated Rap1 in the absence of cAMP , increased ERK and Akt phosphorylation . Positive_regulation EPHB2 XRCC5 14551200 1175539 Experiments involving the expression of the dominant negative mutants of Ras and Rap1 signaling ( RasN17 or Rap1N17 ) indicate that both GTPases Ras and Rap1 are recruited for the ERK activation by VIP and PACAP38 , whereas is poorly *involved* in TRH or EGF induced [ERK] activation . Positive_regulation EPHB2 XRCC5 14607972 1162183 Functionally , either interferes with Ras mediated ERK activation or *activates* [ERK] independently of Ras in a cell-context dependent manner . Positive_regulation EPHB2 XRCC5 16507992 1529678 We confirm that the PKA independent activation of by Epac1 activates a perinuclear pool of Rap1 and that this does not *result* in [ERK] activation . Positive_regulation EPHB2 XRCC5 17472964 1750445 Moreover , Ca2+ induced *activation* of [ERK] through and expression of loricrin were reduced in primary cultured nectin-1-/- keratinocytes ; Positive_regulation EPHB2 XRCC6 11146560 760890 We provide evidence that mutants *promote* [ERK] activation and that the active protein induces a more sustained activation than the inactive protein . Positive_regulation EPHB2 XRCC6 11228165 788435 is *involved* in cell stretching modulation of p38 but not [ERK] or JNK MAP kinase . Positive_regulation EPHB2 XRCC6 11479306 860642 Moreover , inhibition of by a Rap1 GTPase activating protein-1 also *resulted* in a decrease in [ERK] and Akt phosphorylation , which was not further decreased by cAMP , suggesting that cAMP inhibits ERK and Akt by inhibiting Rap1 . Positive_regulation EPHB2 XRCC6 11479306 860698 The *role* of in [ERK] and Akt activity was further demonstrated by our observation that an active form of Epac , which activated Rap1 in the absence of cAMP , increased ERK and Akt phosphorylation . Positive_regulation EPHB2 XRCC6 14551200 1175544 Experiments involving the expression of the dominant negative mutants of Ras and Rap1 signaling ( RasN17 or Rap1N17 ) indicate that both GTPases Ras and Rap1 are recruited for the ERK activation by VIP and PACAP38 , whereas is poorly *involved* in TRH or EGF induced [ERK] activation . Positive_regulation EPHB2 XRCC6 14607972 1162186 Functionally , either interferes with Ras mediated ERK activation or *activates* [ERK] independently of Ras in a cell-context dependent manner . Positive_regulation EPHB2 XRCC6 16507992 1529682 We confirm that the PKA independent activation of by Epac1 activates a perinuclear pool of Rap1 and that this does not *result* in [ERK] activation . Positive_regulation EPHB2 XRCC6 17472964 1750449 Moreover , Ca2+ induced *activation* of [ERK] through and expression of loricrin were reduced in primary cultured nectin-1-/- keratinocytes ; Positive_regulation EPHB2 YWHAB 12364324 1019129 GLP1 stimulated activation of [Erk] is blocked by inhibitors of MEK , but GLP1 does not *induce* the activation of A-Raf , , C-Raf , or Ras . Positive_regulation EPHB2 YWHAB 18490924 1944917 is *required* for [ERK] activation and tumor progression in a mouse model of pancreatic beta-cell carcinogenesis . Positive_regulation EPHB2 YWHAB 23893412 2839591 Recently , it has been reported that in melanoma cells harboring oncogenic Ras mutations , does not bind to Ras and does not *contribute* to basal [ERK] activation . Positive_regulation EPHB2 ZAP70 15307176 1284830 CD46 enhanced TCR/CD3 induced tyrosine phosphorylation of CD3zeta and , as well as the *activation* of the [ERK] , JNK , and p38 , but did not modify intracellular calcium . Positive_regulation EPHB2 ZAP70 9553143 499552 Consistent with the hypothesis that is *required* for activation of [Erk] in response to an oxidative stimulus , Erk1 and Erk2 could be rapidly activated in Jurkat cells but not in P116 cells upon addition of H2O2 . Positive_regulation EPHB2 ZAP70 9553143 499554 Surprisingly , although was *required* for H2O2 mediated [Erk] activation , Erk activation in response to T cell antigen receptor engagement did not require ZAP-70 . Positive_regulation EPHB2 ZGLP1 12364324 1019018 Additionally , we provide evidence that *stimulated* activation of [Erk] requires an influx of calcium through L-type voltage gated calcium channels and the activation of calcium/calmodulin dependent protein kinase II . Positive_regulation EPHB2 ZGLP1 12364324 1019130 GLP1 stimulated activation of [Erk] is blocked by inhibitors of MEK , but does not *induce* the activation of A-Raf , B-Raf , C-Raf , or Ras . Positive_regulation EPHB2 ZGLP1 22412973 2567174 In this report , we characterise the relationship between L-type VGCC mediated changes in intracellular Ca ( 2+ ) concentration ( [ Ca ( 2+ ) ] ( i ) ) and the activation of ERK , and demonstrate that the sustained activation of [ERK] ( up to 30 min ) in *response* to requires the continual activation of the L-type VGCC yet does not require a sustained increase in global [ Ca ( 2+ ) ] ( i ) or Ca ( 2+ ) efflux from the endoplasmic reticulum . Positive_regulation EPHB3 EFNB1 20633976 2316725 Identification of expression in prostatic mesenchyme and a *role* for [EphB-EphrinB] signalling in prostate development . Positive_regulation EPHB3 EFNB1 21952679 2488094 In addition , EphB2 and [EphB3] play a cell-autonomous role in regulating the transitions of double negative to double positive cells and of double positive to single positive thymocytes and the lack of these molecules or their ligands and ephrin B2 *induces* profound alterations of the TEC maturation and in the arrangement of epithelial network . Positive_regulation EPHB3 EFNB1 22475621 2715230 *Activation* of [EphB] receptors by ( efnB ) ligands on neuronal cell surface regulates important functions , including neurite outgrowth , axonal guidance , and synaptic plasticity . Positive_regulation EPHB4 EFNB1 20633976 2316726 Identification of expression in prostatic mesenchyme and a *role* for [EphB-EphrinB] signalling in prostate development . Positive_regulation EPHB4 EFNB1 22475621 2715233 *Activation* of [EphB] receptors by ( efnB ) ligands on neuronal cell surface regulates important functions , including neurite outgrowth , axonal guidance , and synaptic plasticity . Positive_regulation EPHB6 CCND1 21377781 2404388 In this study , we demonstrated that FHL2 overexpression *inhibits* the proliferation of human HCC cells [Hep3B] through cell cycle regulation by decreasing expression while increasing the expressions of p21 and p27 . Positive_regulation EPHB6 EFNB1 20633976 2316727 Identification of expression in prostatic mesenchyme and a *role* for [EphB-EphrinB] signalling in prostate development . Positive_regulation EPHB6 EFNB1 22475621 2715236 *Activation* of [EphB] receptors by ( efnB ) ligands on neuronal cell surface regulates important functions , including neurite outgrowth , axonal guidance , and synaptic plasticity . Positive_regulation EPO IL1B 9386984 466437 These findings suggest that systemic TNF alpha or are not *involved* in the [erythropoietin] response to ACD . Positive_regulation EPO NT5E 16468051 1561419 The aim of the present study was to evaluate the *role* of in [erythropoietin (EPO)] production and to determine its influence on basal kidney perfusion using a CD73 knockout mutant recently generated by us . Positive_regulation EPO STAT4 7760829 308010 In contrast , IL-2 , IL-3 , and [erythropoietin] *induce* the tyrosine phosphorylation of Stat5 while IL-12 uniquely induces the tyrosine phosphorylation of . Positive_regulation EPO TNF 20012512 2199969 We have developed a method that cells exhibiting typical dendritic cell ( DC ) characteristics are generated from human CD34 ( + ) cells and phagocytose cogenerating erythroid progenitor cells in the *presence* of , interleukin-3 , stem cell factor and [erythropoietin] . Positive_regulation EPO TNF 9386984 466436 These findings suggest that systemic or IL-1 beta are not *involved* in the [erythropoietin] response to ACD . Positive_regulation EPOR CAPN8 8573070 349932 The inhibitors N-acetyl-leucyl-leucyl-norleucinal ( ALLN ) and N-acetyl-leucyl-leucyl-methional ( ALLM ) *inhibited* [EPO-R] degradation profoundly . Positive_regulation EPS15 TNF 24269888 2893102 In the present study , we found that stimulation of HeLa cells with EGF or *induced* transient phosphorylation of [Eps15] at Ser-796 . Positive_regulation EPX EPHB2 16435392 1527765 In this study we confirmed the presence of the erythropoietin (EPO) receptor on both cultured cortical neurons and PC12 cells and showed that [EPO] can *induce* changes in p38 , , and JNK signaling molecules in these cells . Positive_regulation EPX EPHB2 23820731 2815856 [EPO] *induced* a rapid activation of and also phosphorylation of endogenous Raf . Positive_regulation EPX EPHB2 24294939 2898984 Transporter expression in response to blocking [EPO] induced *activation* of JAK-2 , , and PI3K/Akt was changed to a different extent . Positive_regulation EPX IL1B 12958195 1138271 Addition of 10 microM K-7174 rescued these inhibitions of [Epo] protein production and promoter activity *induced* by , TNF-alpha , or L-NMMA , respectively . Positive_regulation EPX STK39 7527668 280879 In these cells , [Epo] also *induced* the expression of a , Pim-1 . Positive_regulation EPX TNF 12393629 1035730 [EPO] also could *induce* expression in BAF3 and DA3 myeloid cells ectopically expressing EPOR . Positive_regulation EPX TNF 12958195 1138270 Addition of 10 microM K-7174 rescued these inhibitions of [Epo] protein production and promoter activity *induced* by IL-1beta , , or L-NMMA , respectively . Positive_regulation EPX TNF 14769150 1182390 IFN-gamma ( 100 U/ml ) and ( 1000 U/ml ) or IL-5 ( 200 pM ) *caused* a significant increase in the expression of the [eosinophil peroxidase (EPO)] and the major basic protein (MBP) genes . Positive_regulation EPX TNF 8185237 256636 IL-1 , , and possibly other cytokines could *contribute* to defective [EPO] production in renal and nonrenal immune responses . Positive_regulation ERAP1 TLR7 24688025 2935182 *mediated* secretion of [endoplasmic reticulum aminopeptidase 1] from macrophages . Positive_regulation ERBB2 EPHB2 15572377 1368347 Here we applied a combination of computational modeling and quantitative experimental studies of the dynamic interactions between EGFR and [HER2] and their downstream *activation* of to understand this complex signaling system . Positive_regulation ERBB2 EPHB2 16357167 1492828 Constitutive activation of the extracellular signal regulated kinase ( ERK ) pathway also enhanced PDEF induced motility and invasion , suggesting that *activation* of the activated protein kinase by [ErbB2] and CSF-1R/CSF-1 can cooperate with PDEF to promote motility and invasion . Positive_regulation ERBB2 EPHB2 21403841 2404529 Furthermore , we show that AR-mediated induction of *requires* [ErbB2] , and AR activity , in turn , regulates ErbB2 expression as an AR target gene . Positive_regulation ERBB2 EPHB2 21760527 2456247 We have in the current study compared the effects of Nimotuzumab and Cetuximab on binding of EGF as well as on inhibition of constitutive [EGFR-ErbB2] dimerization and downstream *activation* of . Positive_regulation ERBB2 HBEGF 12481249 1032722 ErbB1 and [ErbB2] receptors were *activated* by . Positive_regulation ERBB2 TNF 16291729 1526045 In contrast to anti-HER2/neu IgG3 , anti-HER2/neu *induces* potent [HER2/neu] signaling , activating the downstream mitogen activated protein kinase (MAPK) and Akt pathways in SKBR3 cells . Positive_regulation ERBB2 TNF 18701712 1950527 also *activated* [ErbB2] , and loss of ErbB2 expression increased TNF induced apoptosis . Positive_regulation ERBB2 TNF 19760502 2264278 We found that *induces* [ErbB-2] phosphorylation in mouse breast cancer C4HD cells and in the human breast cancer cell lines SK-BR-3 and BT-474 . Positive_regulation ERBB2 TNF 19760502 2264281 [ErbB-2] phosphorylation at Tyr877 residue was *mediated* by induced c-Src activation . Positive_regulation ERBB2 TNF 19760502 2264282 Moreover , *promoted* [ErbB-2/ErbB-3] heterocomplex formation , Akt activation and NF-kappaB transcriptional activation . Positive_regulation ERBB2 TNF 19760502 2264293 Interestingly , our work disclosed that is able to *transactivate* [ErbB-2] and use it as an obligatory downstream signaling molecule in the generation of mitogenic signals . Positive_regulation ERBB2 TNF 22922291 2710275 It was uncovered that [Her-2] was a new substrate for caspase-8 and that stimulation *resulted* in a caspase-8 dependent Her-2 cleavage in MCF-7 breast adenocarcinoma cells defective for nuclear factor ?B ( NF?B ) activation . Positive_regulation ERBB2 TNFAIP2 15609325 1369121 [ERBB2] overexpression suppresses the transcription of antiangiogenic factors ( e.g. , Sparc , Timp3 , Serpinf1 ) but *induces* expression of angiogenic factors ( e.g. , Klf5 , , Sema3c ) . Positive_regulation ERBB2IP EPHB2 24711380 2935547 In conclusion , [Erbin] is an inhibitor of pathological cardiac hypertrophy , and this inhibition is *mediated* , at least in part , by modulating signaling . Positive_regulation ERBB3 HBEGF 8626392 355671 Consequently , only NDF , , and BTC significantly *stimulated* association of phosphatidylinositol kinase activity with [ErbB-3] . Positive_regulation ERBB3 TNF 17908459 1803316 Since is *involved* in the activation of both TNF-alpha and [ErbB3] , we established rat models of COPD to investigate the expressions of TACE , TNF-alpha and ErbB3 and to explore the correlations among TACE , TNF-alpha and ErbB3 respectively . Positive_regulation ERBB3 TNF 19760502 2264283 Moreover , *promoted* [ErbB-2/ErbB-3] heterocomplex formation , Akt activation and NF-kappaB transcriptional activation . Positive_regulation ERBB3 TNFSF10 22579651 2632028 Here we show that inhibition of p38a is followed by mediated *activation* of caspase-8 and FoxO3A dependent [HER3] upregulation with consequent overactivation of the MEK-ERK1/2 survival pathway . Positive_regulation ERBB4 HBEGF 17761534 1807944 [ErbB4] was *activated* by both HRG-beta1 and stimulation ; Positive_regulation ERBB4 HBEGF 21617117 2459139 Using neutralizing antibodies , we show that ( HB-EGF ) is *required* for [ErbB4] phosphorylation in response to TNF . Positive_regulation ERBB4 HBEGF 8626392 355673 Among the EGF agonists , *induced* a low level of [ErbB-4] tyrosine phosphorylation , while BTC was as efficient as NDF in activating ErbB-4 . Positive_regulation ERBB4 TNF 21617117 2459136 TNF-a converting enzyme mediated [ErbB4] *transactivation* by promotes colonic epithelial cell survival . Positive_regulation ERBB4 TNF 21617117 2459137 We have recently shown that *increases* the kinase activity of [ErbB4] , a member of the epidermal growth factor receptor family that is elevated in mucosa of IBD patients and that promotes colon epithelial cell survival . Positive_regulation ERBB4 TNF 21617117 2459138 Using neutralizing antibodies , we show that heparin binding EGF-like growth factor ( HB-EGF ) is required for [ErbB4] phosphorylation in *response* to . Positive_regulation ERBB4 TNF 21617117 2459141 Pharmacological or genetic inhibition of the metalloprotease TACE , which mediates HB-EGF release from cells , blocked *induced* [ErbB4] activation . Positive_regulation ERCC1 MAP2K6 22053010 2562620 Enhancement of p38 activation by constitutively active ( MKK6E ) *increased* [ERCC1] protein levels . Positive_regulation ERCC2 TNF 16874302 1600734 Upon *stimulation* of the cells by , NF-kappaB and [TFIIH] are rapidly recruited to the promoter together with additional Mediator and RNAP II , but CDK8 is lost . Positive_regulation ERCC3 TNF 16874302 1600735 Upon *stimulation* of the cells by , NF-kappaB and [TFIIH] are rapidly recruited to the promoter together with additional Mediator and RNAP II , but CDK8 is lost . Positive_regulation ERCC6L STK39 18083840 1837107 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation EREG EPHB2 23549083 2772623 Additionally , we demonstrated that fibroblast derived [EREG] *requires* activation to induce proliferation of intestinal epithelial cells ( IEC ) and tumor development in vivo . Positive_regulation EREG HBEGF 18079685 1834434 Epiregulin increased the expression of HB-EGF and AR , while TGF-alpha , , AR , and EGF *increased* the expression of [epiregulin] in HCECs . Positive_regulation EREG IL1B 16847181 1588131 The messenger RNA expressions of LARC ( liver and activation regulated chemokine ) , GMCSF ( granulocyte-macrophage colony stimulating factor ) , [epiregulin] , ICAM1 ( intercellular adhesion molecule 1 ) , and TGFA ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation EREG TNF 20161853 2179371 Furthermore , *induced* secretion of IL-6 , IL-8 , EGF , HGF , TGF-alpha , [epiregulin] , and amphiregulin were compared among these keratinocytes . Positive_regulation EREG TNF 20161853 2179375 The significant induction of *increased* IL-6 , IL-8 , EGF , HGF , TGF-alpha , [epiregulin] , and amphiregulin , but the increase in these cytokines and growth factors were not different among normal skin , uninvolved , and involved psoriasis . Positive_regulation ERF CLU 22967941 2693525 Clusterin inhibition could augment the chemosensitivity of human pancreatic cancer cells by inhibition of *dependent* [pERK1/2] activation . Positive_regulation ERF TNF 22616553 2632450 *increased* [p-ERK1/2] and NF-?B p65 levels , with higher levels in allergen exposed ASMC , post-TNF-a stimulation ( P < 0.001 ) . Positive_regulation ERF TNF 22616553 2632452 MXF , DXM and the combination of MXF with DXM inhibited *stimulated* [p-ERK1/2] and NF-?B p65 levels by 34 , 40 and 62 % , and 33 , 38 and 64 % , respectively . Positive_regulation ERN1 EPHB2 24240056 2892371 Inhibition of MEK partially blocked IRE1a and ATF6 activation , suggesting that signaling *contributed* to sustained activation of [IRE1a] and ATF6 . Positive_regulation ERN1 MAP2K6 24240056 2892377 Inhibition of partially *blocked* [IRE1a] and ATF6 activation , suggesting that MEK/ERK signaling contributed to sustained activation of IRE1a and ATF6 . Positive_regulation ERN1 RNASE1 11069889 747890 These mutants were used to demonstrate that the activity is *required* for UPR activation by [IRE1 alpha] and IRE1 beta . Positive_regulation ERN1 RNASE7 11069889 747898 These mutants were used to demonstrate that the activity is *required* for UPR activation by [IRE1 alpha] and IRE1 beta . Positive_regulation ERN1 TLR7 23942232 2840854 Further analyses demonstrated that tumour necrosis factor (TNF) receptor associated factor 6 ( TRAF6 ) plays a key role in mediated [IRE1a] *activation* by catalysing IRE1a ubiquitination and blocking the recruitment of protein phosphatase 2A (PP2A) , a phosphatase that inhibits IRE1a phosphorylation . Positive_regulation ERN1 TLR7 23942232 2840865 In summary , we discovered a novel regulatory axis through TRAF6 mediated IRE1a ubiquitination in regulating induced [IRE1a] *activation* in pro-inflammatory cytokine production , and demonstrated that IRE1a is a potential therapeutic target for inflammatory arthritis . Positive_regulation ERN1 TNF 22319522 2553780 PTX ( 1 mM ) reduced induced *activation* of GRP78 , p-eIF2 , ATF4 , [IRE1a] , and CHOP in vitro . Positive_regulation ERN2 RNASE1 11069889 747878 These mutants were used to demonstrate that the activity is *required* for UPR activation by IRE1 alpha and [IRE1 beta] . Positive_regulation ERN2 RNASE7 11069889 747886 These mutants were used to demonstrate that the activity is *required* for UPR activation by IRE1 alpha and [IRE1 beta] . Positive_regulation ERVK-15 ITGB2 14969582 1242942 In human PMN ( polymorphonuclear cells ) , challenged by P-selectin , the ( macrophage antigen-1 ) *promoted* the activation of the SRC ( cellular homologue of Rous sarcoma virus oncogenic protein ) family members HCK ( haematopoietic cell kinase ) and LYN ( an SRC family protein tyrosine kinase ) and phosphorylation of a [P-110] ( 110 kDa protein ) . Positive_regulation ERVK-6 CST6 7930530 274692 We postulate that chicken functions to *regulate* [proteinase] activity in the CSF and therefore may function as a protective factor for the cellular elements of the central nervous system . Positive_regulation ERVK-6 CTGF 12753604 1090317 These results indicate that in order to induce changes in porcine fibroblasts a molecule with an intact C-terminal domain is required , and that *regulates* porcine fibroblast extracellular matrix molecule , growth factor , and [proteinase] inhibitor gene expression without apparently affecting matrix metalloproteinase mRNA levels . Positive_regulation ERVK-6 F2R 10780327 687586 Stimulation of human platelets with thrombin or agonist peptide ( TRAP/ Ser-Phe-Leu-Leu-Arg-Asn ) *resulted* in phosphorylation of the [protease activated receptor 1 (PAR1)] . Positive_regulation ERVK-6 F2R 23201139 2730686 KLK4 is an endogenous activator of [protease activated receptor 1 (PAR1)] in HT-29 colorectal adenocarcinoma cells , *inducing* signaling and subsequent ERK1/2 activation . Positive_regulation ERVK-6 F2R 9564545 500733 Receptor activating peptides distinguish thrombin receptor ( ) and [protease activated receptor 2 (PAR-2)] *mediated* hemodynamic responses in vivo . Positive_regulation ERVK-6 F3 17363687 1741237 initiates coagulation and indirectly *triggers* thrombin dependent [protease activated receptor (PAR)] signaling . Positive_regulation ERVK-6 F3 19795460 2224590 *mediated* [protease activated receptor (PAR)-2] signaling is associated with a promigratory , invasive and proangiogenic phenotype in experimental models of breast cancer and has been mechanistically coupled to phosphorylation of the TF cytoplasmic domain ( pTF ) . Positive_regulation ERVK-6 FAS 11044257 742466 Using various tetrapeptide inhibitors for caspase and its associated factor , we additionally demonstrated that inhibitors for caspase 3 ( Ac-DEVD-CHO ) and caspase 8/granzyme B ( Ac-IETD-CHO ) suppressed CTL induced cell death , but an inhibitor for *activated* serine [proteinase] , which acts for the caspase 3 activator , did not , suggesting that CTL induced cell death was initiated by the Perforin/Granzyme B system , rather than the Fas ligand/Fas system . Positive_regulation ERVK-6 MMP28 12034745 968289 VMP3 shows [proteinase] activity and is *inhibited* by EDTA or the inhibitor GM 6001 , but in contrast to all known proteinases , VMP3 clearly prefers copper for activity rather than zinc . Positive_regulation ERVK-6 MMP28 16772705 1572802 In addition , the proteolytic activity was almost completely inhibited by BS-10 , a inhibitor , but not by the serine [proteinase] *inhibitors* , cysteine proteinase inhibitors and aspartic proteinase inhibitors . Positive_regulation ERVK-6 MMP7 11451908 836798 Furthermore , in models of airway injury , expression is upregulated in migrating epithelial cells , and the activity of this [proteinase] is *required* for repair of airway wounds . Positive_regulation ERVK-6 MMP7 12034745 968304 VMP3 shows [proteinase] activity and is *inhibited* by EDTA or the inhibitor GM 6001 , but in contrast to all known proteinases , VMP3 clearly prefers copper for activity rather than zinc . Positive_regulation ERVK-6 MMP7 16772705 1572817 In addition , the proteolytic activity was almost completely inhibited by BS-10 , a inhibitor , but not by the serine [proteinase] *inhibitors* , cysteine proteinase inhibitors and aspartic proteinase inhibitors . Positive_regulation ERVK-6 PLAU 11027463 738926 The following activation mechanism for [proteinase] might occur : coexpressed with MMP-9 *activated* plasminogen , and plasmin activated proMMP-3 , which was secreted depending upon inflammatory infiltration , and then MMP-3 activated proMMP-9 , resulting in colorectal cancer progression and metastasis . Positive_regulation ERVK-6 PLAU 18460030 1927022 The addition of aprotinin , a serine [proteinase] *inhibitor* , and tranexamic acid , a inhibitor , inhibited the plasmin induced impairment of BM assembly and facilitated BM reorganization , thereby improving the epidermal structure . Positive_regulation ERVK-6 TNF 11773040 899368 The *role* of in stimulating retinal microvascular endothelial cell ( RMVEC ) [proteinase] production was evaluated using isolated murine RMVECs grown in normoxic or hypoxic conditions . Positive_regulation ERVK-6 TNF 1322806 192309 Neutral [proteinase] and PGE2 production by BNC was also *induced* by ( 0.2-200 ng/ml ) in a time dependent ( 0-72 hr ) manner . Positive_regulation ERVK-6 TNF 2169729 142060 Among the cytokines and growth factors examined , only human recombinant induced and *stimulated* the [proteinase] with concomitant increase in TIMP expression , but matrix metalloproteinase 2 ( 72-kDa gelatinase/type IV collagenase ) expression was unchanged . Positive_regulation ERVK-6 TNF 9688944 522687 Because can *induce* [proteinase] expression in endothelial cells , we determined whether proteinases cause both the alteration of the Fn matrix and the permeability increase as is often speculated . Positive_regulation ERVW-1 TNF 17258784 1725377 Taken together , these results illustrate a role for p65 in regulating the ERVWE1 promoter and in *mediated* induction of [syncytin-1] in multiple sclerosis . Positive_regulation ESAM TNF 10484438 644093 The dual radiolabeled monoclonal antibody technique was used to quantify constitutive and *induced* expression of intercellular adhesion molecule 1 ( ICAM-1 ) , vascular cell adhesion molecule 1 ( VCAM-1 ) , ICAM-2 , P-selectin , E-selectin , and [platelet-endothelial cell adhesion molecule] 1 ( PECAM-1 ) in different vascular beds of normal ( C57Bl/6 ) and RM-1 tumor bearing mice . Positive_regulation ESAM TNF 15694007 1376332 Troglitazone , a PPAR-gamma activator prevents [endothelial cell adhesion molecule] expression and lymphocyte adhesion *mediated* by . Positive_regulation ESAM TNF 18212564 1857921 The authors investigated the impact of different anesthetics and morphine on *induced* [endothelial cell adhesion molecule] expression . Positive_regulation ESAM TNF 19967061 2009308 Heparin Attenuates the Expression of *induced* Cerebral [Endothelial Cell Adhesion Molecule] . Positive_regulation ESAM TNF 9366433 463251 Lymphocytes mediate *induced* [endothelial cell adhesion molecule] expression : studies on SCID and RAG-1 mutant mice . Positive_regulation ESAT EMP1 9573013 501911 We show EPO expression in the *stimulated* [BFU-Es at] both mRNA and protein levels . Positive_regulation ESM1 TNF 11025405 738531 By ELISA , we show that the secretion of [ESM-1] is significantly enhanced in the *presence* of . Positive_regulation ESM1 TNF 8702785 375986 In addition , when IFNgamma was combined with TNFalpha , IFNgamma inhibited the *induced* increase of [ESM-1] mRNA level . Positive_regulation ESPL1 CTGF 18583340 1946718 overexpression suppressed Notch signaling and *induced* the transcription of hairy and [E (spl)-1] ( HES)-1 , by Notch independent mechanisms . Positive_regulation ESR1 CCND1 16061635 1438990 expression *enhanced* [ERalpha] recruitment to an ERE . Positive_regulation ESR1 CCND1 20338923 2260575 Previous reports have shown that can directly *enhance* [estrogen receptor] activity and inhibit androgen receptor activity in a ligand independent manner and thus may play an important role in hormone-responsive malignancies . Positive_regulation ESR1 CCND1 23864650 2835145 Although it is known that *regulates* [estrogen receptor] ( ER ) a transactivation using heterologous reporter systems , the in vivo biological significance of cyclin D1 to estrogen dependent signaling , and the molecular mechanisms by which cyclin D1 is involved , are yet to be elucidated . Positive_regulation ESR1 CCND1 9039267 415707 CDK independent *activation* of [estrogen receptor] by . Positive_regulation ESR1 CCND1 9039267 415709 The *activation* of [estrogen receptor] by is not inhibited by anti-estrogens . Positive_regulation ESR1 CCND1 9271411 450331 We show that ectopic expression of can *stimulate* the transcriptional activity of the [estrogen receptor] in the absence of estradiol and that this activity can be inhibited by 4-hydroxytamoxifen and ICI 182,780 . Positive_regulation ESR1 CCND1 9271411 450332 *Stimulation* of the [estrogen receptor] by is independent of cyclin dependent kinase 4 activation . Positive_regulation ESR1 EPHB2 15190886 1256848 This response is replicated in vitro and involves *mediated* activation of the [estrogen receptor (ER) alpha] and upregulation of estrogen response element activity . Positive_regulation ESR1 EPHB2 18492705 1933632 [ER alpha] is involved in the transient activation of ERK/mitogen activated protein kinase (MAPK) by genistein via its early association with IGF-IR , leading to hyper-responsiveness of LM cells and confirming that ER signaling is *enhanced* by activation of in LM cells . Positive_regulation ESR1 FAS 15094777 1258185 inhibition also resulted in a marked downregulation of E2-stimulated ERalpha expression , and noticeably *impaired* E2-induced [ERalpha] nuclear accumulation . Positive_regulation ESR1 FAS 15094777 1258188 Moreover , depletion of by RNAi also *caused* loss of [ERalpha] expression , downregulation of PR , and accumulation of p21WAF1/CIP1 and p27Kip1 in E2-stimulated Ishikawa cells . Positive_regulation ESR1 FOXA1 20501593 2263818 Using breast cancer cell lines , we also demonstrate that *regulates* [ERalpha] expression , but not GATA3 . Positive_regulation ESR1 FOXO1 11435445 850335 *augmented* [ER alpha] transactivation through an estrogen response element . Positive_regulation ESR1 IL1B 10568836 567946 Evidence for transcriptional *activation* of [ERalpha] by in breast cancer cells . Positive_regulation ESR1 IL1B 10568836 567948 We next examined whether could directly *activate* [ERalpha] . Positive_regulation ESR1 IL1B 10568836 567949 These results provide compelling evidence for direct transcriptional *activation* of [ERalpha] by . Positive_regulation ESR1 KLF9 20164373 2236321 We hypothesized that functions as a tumor suppressor , and that loss of its expression *enhances* [ESR1] signaling . Positive_regulation ESR1 KLF9 20164373 2236323 Loss of expression *resulted* in increased glandular [ESR1] immunoreactivity with DES , without effects on serum estradiol levels . Positive_regulation ESR1 MAP2K6 20021813 2175433 ST [induced-p-ERalpha] expression was partially *blocked* by ERalpha and inhibitors . Positive_regulation ESR1 NR2F1 17549341 1752492 ( chicken ovalbumin upstream promoter-transcription factor I ) is an orphan nuclear receptor , which is expressed in various tissues and *regulates* the [estrogen receptor (ER)] by competition for DNA binding . Positive_regulation ESR1 TNF 14970864 1209292 From these results , we propose that expression or PI3-kinase activation *lead* to reduced levels of [ERalpha] protein in cancer cells and corresponding loss of transrepression function and acquisition of an invasive phenotype . Positive_regulation ESR1 TNF 17598955 1815895 These data indicate that PGF2alpha , and IFNgamma *regulate* [ERalpha] and ERbeta mRNA expressions in bovine luteal cells . Positive_regulation ESR2 CCND1 23060014 2763554 expression is *involved* in [estrogen receptor beta] ( ERß ) in human prostate cancer . Positive_regulation ESRRA EPHB2 19920079 2171795 This synergistic effect is seen at the global transcriptional level , *requires* both the and phosphoinositide 3-kinase (PI3K) signalling pathways and is mediated by the transcription factor [ERRalpha] . Positive_regulation ESRRA PGC 12522104 1063969 The transcriptional coactivator *regulates* the expression and activity of the orphan nuclear receptor [estrogen related receptor alpha] ( ERRalpha ) . Positive_regulation ESRRA PGC 12522104 1063971 In this study , we show that the transcriptional coactivator , which is implicated in the control of energy metabolism , *regulates* [ERRalpha] at two levels . Positive_regulation ESRRA PGC 12522104 1063973 First , *induces* the expression of [ERRalpha] . Positive_regulation ETS1 CTGF 20201953 2259339 Additional experiments showed that *induces* phosphorylation of ERK1/2 , [Ets1] and c-Jun. Consistent with the stimulatory role of ERK1/2/Ets1 in the expression of MMP1 , the ERK1/2 inhibitor UO126 prevented the phosphorylation of ERK1/2 and Ets1 and completely abrogated the induction of MMP1 after CCN2 overexpression , while having no effect on c-Jun activation . Positive_regulation ETS1 EPHB2 17105652 1663650 Inhibition of activation *reduces* [ETS1] phosphorylation and SYN expression . Positive_regulation ETS1 EPHB2 19567783 2111197 The treatment of HepG2 cells with HGF induced *dependent* phosphorylation of [Ets] , which leads to its activation , before the up-regulation of p16 , suggesting that another factor suppresses Ets activity . Positive_regulation ETS1 EPHB2 24085800 2902631 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of and *activation* of [Ets-1] transcription factor . Positive_regulation ETS1 IL1B 12960175 1164263 *induced* the formation of [p300-Ets-1] complexes without affecting expression of CITED2 . Positive_regulation ETS1 MAP2K6 15111329 1241152 The VEGF induced mRNA increase of [Ets-1] was *suppressed* by a tyrosine kinase inhibitor ( genistein ) , by inhibitors of ( mitogen activated protein and extracellular signal regulated kinase kinase ) ( PD98059 and UO126 ) , and by inhibitors of protein kinase C ( GF109203X , staurosporine , and Gö6976 ) . Positive_regulation ETS1 TCN1 8973718 403086 First , by washout of the mucous blanket of ET , the , the ratio of passive tubal resistances at two different airflow rates , significantly *increased* in all the 6 [ETs] of 5 cats , and all returned to the baseline within 50 min . Positive_regulation ETS1 TNF 11229456 788634 Both IL-1 and *induced* pronounced up-regulation of [Ets-1] in synovial fibroblasts . Positive_regulation ETS1 TNF 11689211 876133 *induces* expression of transcription factors c-fos , Egr-1 , and [Ets-1] in vascular lesions through extracellular signal regulated kinases 1/2 . Positive_regulation ETS1 TNF 11689211 876142 In cultured RAW 264.7 mouse macrophages , similarly *induced* the expression of [Ets-1] , Egr-1 , and c-fos . Positive_regulation ETS1 TNF 14734780 1199529 Furthermore , treatment of fibroblasts with Ets-1 antisense oligonucleotides down-regulated *induced* [Ets-1] , MMP-9 , and , to a lesser extent , tenascin protein expression or activity . Positive_regulation ETS1 TNF 24189042 2868407 *induced* mRNA expression of [ETS-1] and ß6-integrin in HT29 IEC and in CLPF from fistulizing CD patients . Positive_regulation ETS2 EPHB2 19567783 2111198 The treatment of HepG2 cells with HGF induced *dependent* phosphorylation of [Ets] , which leads to its activation , before the up-regulation of p16 , suggesting that another factor suppresses Ets activity . Positive_regulation ETS2 TCN1 8973718 403087 First , by washout of the mucous blanket of ET , the , the ratio of passive tubal resistances at two different airflow rates , significantly *increased* in all the 6 [ETs] of 5 cats , and all returned to the baseline within 50 min . Positive_regulation ETS2 TNF 16142752 1454892 Bcl-xL or Ets-2 overexpression protected osteoclasts from ALN induced apoptosis , and *stimulated* Bcl-xL and [Ets-2] expression in osteoclasts . Positive_regulation ETS2 UCA1 24069250 2847110 Taking into account the anti-apoptosis function of Ets-2 , our data suggested that Ets-2 regulates apoptosis process by regulating the expression of UCA1 , moreover may be *involved* in the activation of Akt signaling pathway by [Ets-2] in bladder cancer cells . Positive_regulation ETV5 MAP2K6 22998872 2679117 Further , the Ets transcription family member [Etv5/Erm] is strongly *regulated* by and Erm overexpression can rescue the gliogenic potential of Mek deleted progenitors . Positive_regulation ETV7 CCL28 19029808 2001552 function in the DNA damage response does not *require* its interaction with [Tel2] . Positive_regulation ETV7 CEBPZ 19587307 2122622 [ETV] *induces* changes in brain volume and that can be predicted by using simple metrics . Positive_regulation ETV7 CPB1 12902096 1118907 Despite a significantly greater prime volume and a more positive intraoperative fluid balance , [ETV] did not change with bilateral ECC but *increased* with conventional . Positive_regulation ETV7 CPB2 12902096 1118908 Despite a significantly greater prime volume and a more positive intraoperative fluid balance , [ETV] did not change with bilateral ECC but *increased* with conventional . Positive_regulation ETV7 SAFB 21950761 2502549 BRCA1 was found to enhance protein expression and *induce* [Tel2] nuclear translocation . Positive_regulation EVI5 RAB31 22778279 2627807 [Evi5] *requires* its activity to fulfill its functions during migration and acts as a GAP protein for Rab11 . Positive_regulation EZH2 EPHB2 23116973 2729254 [EZH2] is *regulated* by and targets integrin alpha2 gene to control Epithelial-Mesenchymal Transition and anoikis in colon cancer cells . Positive_regulation EZH2 MAP2K6 22222375 2544522 MEK-inhibition or Elk-1-knockdown downregulated [EZH2] , and or EZH2-knockdown *restored* expression of a tumor suppressor , RUNX3 in human and rat pancreatic cancer cells activated by the oncogenic RAS . Positive_regulation EZH2 TNFSF10 20838376 2375365 Finally , knocking down PRAME or [EZH2] , and consequently induction of expression , *enhances* Imatinib sensibility . Positive_regulation EZH2 ZFP57 20808772 2314050 Levels of both and PcG proteins inversely correlated with those of reactive oxygen species ( ROS ) in senescing MEFs , but the treatment of Zfp277 ( -/- ) MEFs with an antioxidant *restored* the binding of [PRC2] but not PRC1 to the Ink4a/Arf locus . Positive_regulation EZR CAPN8 22805611 2645808 Advanced glycation end-products induce *mediated* degradation of [ezrin] . Positive_regulation EZR PDZK1 22696060 2681734 In the melanosome transfer , also *increased* phosphorylation of [ezrin/radixin/moesin (ERM)] and ras related C3 botulinum toxin substrate 1 , but not the expression of proteinase activated receptor-2 . Positive_regulation EZR PODXL 15339978 1291519 activates RhoA and *induces* actin reorganization through NHERF1 and [Ezrin] in MDCK cells . Positive_regulation EZR PODXL 17616675 1769253 *increases* the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with [ezrin] . Positive_regulation EZR PODXL 22412054 2587950 *increases* the migration and invasive properties of cancer cells through its interaction with [ezrin] , which undergoes an increase in phosphorylation through podocalyxin . Positive_regulation EZR TNF 24599913 2942761 Stimulation with and IL-1ß *increased* [ezrin] phosphorylation in RA FLSs . Positive_regulation F10 EPHB2 15882255 1406441 [Factor Xa] *induced* the activation of in mesangial cells and this activation was also completely inhibited by DX-9065a , but not inhibited by PAR1 antagonist . Positive_regulation F10 F2R 11841341 912044 *Activation* of by thrombin and of PAR-2 by [factor Xa] leads to a rapid expression and exposure on the membrane of endothelial cells of both adhesive proteins that mediate an acute inflammatory reaction and of the tissue factor that initiates the blood coagulation cascade . Positive_regulation F10 F2R 18174463 1869947 We show here that annexin 2 acts as a receptor for factor Xa on the surface of human umbilical vein endothelial cells and that annexin 2 facilitates [factor Xa] *activation* of but does not enhance coagulant function of factor Xa . Positive_regulation F10 F3 21052830 2376343 Tissue factor activity was measured as [Factor Xa] generation *induced* by VIIa complex on confluent cells . Positive_regulation F10 PLAT 10037444 592120 When added to confluent HUVEC , [factor Xa] *induced* the expression of tissue factor and the release of and plasminogen activator inhibitor-1 without affecting urokinase expression . Positive_regulation F10 TGM2 12193981 981580 [ Blood [coagulation factor] XIII : *activation* , substrates and structure of a ] . Positive_regulation F11 F3 4266422 506 [PTA] was not *activated* by thrombin , chymotrypsin , papain , ficin , plasmin , plasma kallikrein , tissue , or C. Trypsin converted PTA to its active form enzymatically . Positive_regulation F11 F3 8427954 212446 ( 1 : 500 ) added to plasma did not *induce* cleavage of [factor XI] during a 90-minute incubation , although fibrin formation within 30 seconds indicated that thrombin was generated via the extrinsic pathway . Positive_regulation F11 TGM2 12193981 981587 [ Blood [coagulation factor] XIII : *activation* , substrates and structure of a ] . Positive_regulation F11R MMP28 19141539 2060880 Indeed , the HIV induced decrease in the expression of [JAM-A] and occludin was *restored* by inhibition of activity . Positive_regulation F11R MMP7 19141539 2060895 Indeed , the HIV induced decrease in the expression of [JAM-A] and occludin was *restored* by inhibition of activity . Positive_regulation F11R PECAM1 19714308 2127453 Significant radiation induced increase of ICAM-1 ( intercellular adhesion molecule-1 ) , VCAM-1 ( vascular cell adhesion molecule-1 ) , [JAM-1] ( junctional adhesion molecule-1 ) , beta1-integrin , beta2-integrin , E-cadherin , and P-selectin gene expression could be *detected* in vivo , while ( platelet-endothelial cell adhesion molecule-1 ) gene expression remained unchanged . Positive_regulation F12 TGM2 12193981 981594 [ Blood [coagulation factor] XIII : *activation* , substrates and structure of a ] . Positive_regulation F13A1 CAPN8 2883970 73058 Platelet [factor XIII] is *activated* by . Positive_regulation F13A1 CAPN8 2883970 73134 *Activation* of platelet [factor XIII] by was inhibited by EDTA , leupeptin , and endogenous calpain-specific inhibitor calpastatin . Positive_regulation F13A1 CAPN8 8097064 214621 Cellular [factor XIII] , which lacks B subunit , can be proteolytically *activated* in vitro by thrombin and the intracellular Ca2+ sensitive protease , , in the same way as plasma factor XIII subunit A , and calpain has been suggested as the intracellular protease involved in the activation of cellular factor XIII in platelets . Positive_regulation F13A1 TGM2 10753838 681824 The adhesive activity of [factor XIIIa] was not *dependent* on the activity , and did not involve the factor XIIIb-subunits . Positive_regulation F13A1 TGM2 1675177 157976 Cellular [Factor XIII] correspondingly disappeared and *increased* during the same time . Positive_regulation F13B CAPN8 2883970 73072 Platelet [factor XIII] is *activated* by . Positive_regulation F13B CAPN8 2883970 73148 *Activation* of platelet [factor XIII] by was inhibited by EDTA , leupeptin , and endogenous calpain-specific inhibitor calpastatin . Positive_regulation F13B CAPN8 8097064 214635 Cellular [factor XIII] , which lacks B subunit , can be proteolytically *activated* in vitro by thrombin and the intracellular Ca2+ sensitive protease , , in the same way as plasma factor XIII subunit A , and calpain has been suggested as the intracellular protease involved in the activation of cellular factor XIII in platelets . Positive_regulation F13B TGM2 1675177 157977 Cellular [Factor XIII] correspondingly disappeared and *increased* during the same time . Positive_regulation F2 F3 19548969 2180194 *activated* TEG analysis , d-dimer and fibrinogen concentrations , antithrombin ( AT ) activity , [prothrombin time (PT)] , activated partial thromboplastin time ( aPTT ) , and platelet count were measured using standard techniques on 27 dogs admitted to ICU with a disease known to be associated with hemostatic dysfunction and in 31 clinically healthy control dogs . Positive_regulation F2 F3 23463187 2865513 *mediated* activation of the [prothrombin complex concentrate (PCC)] is differently inhibited by dabigatran , rivaroxaban , and apixaban : potential clinical implication . Positive_regulation F2 F3 7781126 309495 The partially purified [prothrombin] was *activated* by tissue and followed by chromatography on Amberllte and SP-Sephadex . Positive_regulation F2 TGM2 12193981 981601 [ Blood [coagulation factor] XIII : *activation* , substrates and structure of a ] . Positive_regulation F2R ACD 19483102 2107919 We have determined a signaling cascade through [PAR1] , which *involves* phosphatidylinositol ( PI ) kinases , phosphatidylinositol bisphosphate ( PIP ( 2 ) ) , and activation ( independent of P2Y12 ) in the formation of a stable platelet aggregate . Positive_regulation F2R AKT1 18292230 1878606 *enhances* the activity of [PAR1] to promote tau hyperphosphorylation at S262/S356 , a tau species that is not recognized by the CHIP/Hsp90 complex . Positive_regulation F2R AKT2 18292230 1878607 *enhances* the activity of [PAR1] to promote tau hyperphosphorylation at S262/S356 , a tau species that is not recognized by the CHIP/Hsp90 complex . Positive_regulation F2R AKT3 18292230 1878608 *enhances* the activity of [PAR1] to promote tau hyperphosphorylation at S262/S356 , a tau species that is not recognized by the CHIP/Hsp90 complex . Positive_regulation F2R APC 14980205 1213855 By using different anti-PARs antibodies and mice with single PAR1 , PAR3 , or PAR4 deletion , we demonstrated that direct neuronal protective effects of in vitro and in vivo *require* [PAR1] and PAR3 . Positive_regulation F2R APC 14980205 1213858 Thus , [PAR1] and PAR3 *mediate* anti-apoptotic signaling by in neurons , which may suggest novel treatments for neurodegenerative disorders . Positive_regulation F2R APC 17823308 1822944 Thus , when EPCR is bound by protein C , the [PAR-1] cleavage dependent protective signaling responses in endothelial cells can be *mediated* by either thrombin or . Positive_regulation F2R APC 23149848 2707421 's activities , but not thrombin 's , *require* [PAR1] located in caveolae . Positive_regulation F2R APC 23809128 2808147 Recent insights , such as non-canonical *activation* of [PAR1] at Arg46 by and biased PAR1 signaling , provided better understanding of the molecular mechanisms by which APC elicits cytoprotective signaling through cleavage of PAR1 . Positive_regulation F2R APC 25049281 2956769 Understanding how *induces* cytoprotective effects through activation of [PAR1] , whose activation by thrombin is known to induce a proinflammatory response , has become a major research focus in the field . Positive_regulation F2R APEH 16675392 1558858 Here , we show that presenilin and nicastrin prevent tau toxicity by modulating the PI3K/Akt/GSK3beta phosphorylation pathway , whereas *regulates* [aPKC/PAR-1] activities . Positive_regulation F2R ARG1 1328194 197740 *Stimulation* of the [thrombin receptor] of human glomerular mesangial cells by peptide . Positive_regulation F2R ARG2 1328194 197741 *Stimulation* of the [thrombin receptor] of human glomerular mesangial cells by peptide . Positive_regulation F2R ASIP 1328194 197742 *Stimulation* of the [thrombin receptor] of human glomerular mesangial cells by peptide . Positive_regulation F2R ATF6B 20215560 2259576 Consistent with these observations , [PAR1] and PAR2 stimulation of inositol phosphate production and RhoA activation was *blocked* by specific inhibitors of G ( q/11 ) and signaling , respectively . Positive_regulation F2R BMX 20559570 2279991 *regulates* [proteinase-activated-receptor1 (PAR1)] in breast cancer invasion : signaling partners , hierarchy and physiological significance . Positive_regulation F2R CA2 10780319 687581 Thrombin , trypsin , [PAR-1] and PAR-2 agonist peptides *induced* a prominent response in both cell types . Positive_regulation F2R CA2 7514596 254061 Recent studies have shown that the synthetic peptides SFL LRN and SFL LRN PND KYEPF ( thrombin receptor activating peptides ( TRAP ) ) derived from the deduced sequence of the new amino terminus of the cleaved thrombin receptor can mimic [thrombin receptor] activation , act as full agonists for platelet activation , and *induce* prostaglandin I2 production as well as cytosolic increase in human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation F2R CA2 8360259 227768 [Thrombin receptor] activating peptides *induce* mobilization , barrier dysfunction , prostaglandin synthesis , and platelet derived growth factor mRNA expression in cultured endothelium . Positive_regulation F2R CCL2 14577849 1156645 MCP-1 is protective in animal models of endotoxemia , suggesting that APC may prevent lethality in sepsis by *inducing* expression through EPCR dependent activation of endothelial cell [PAR1] . Positive_regulation F2R CCL2 20570895 2290455 We found that [MMP1-PAR1] activation *induces* the secretion of several angiogenic factors from ovarian carcinoma cells , most prominently interleukin (IL)-8 , growth regulated oncogene-alpha ( GRO-alpha ) , and . Positive_regulation F2R CD40LG 10583385 570675 *activated* [PAR1] interacts productively with the distant G-protein . Positive_regulation F2R CPB1 9485228 488278 These results imply that prevention of the *induced* effects on the [thrombin receptor] will lessen postoperative morbidity associated with blood transfusion . Positive_regulation F2R CPB2 9485228 488279 These results imply that prevention of the *induced* effects on the [thrombin receptor] will lessen postoperative morbidity associated with blood transfusion . Positive_regulation F2R CSF3 10343541 616588 [Thrombin receptor] mediated signals *induce* expressions of interleukin 6 and via NF-kappa B activation in synovial fibroblasts . Positive_regulation F2R CYR61 16510585 1530387 Here , we show that ectopic [PAR1] expression *induces* expression of the angiogenic factor ( CCN1 ) in breast cancer cells . Positive_regulation F2R EDN1 7503720 336277 does not *induce* [thrombin receptor] degradation nor change in thrombin receptor mRNA level after 2 h and 24 h of incubation . Positive_regulation F2R EGF 15780084 1385249 These responses which are dependent on its protease activity appear not to be mediated by [PAR-1] activation , the autocrine action of thrombin induced TGF-beta1 secretion , MMP activation , or receptor *transactivation* . Positive_regulation F2R EPHA3 20559570 2279992 *regulates* [proteinase-activated-receptor1 (PAR1)] in breast cancer invasion : signaling partners , hierarchy and physiological significance . Positive_regulation F2R EPHB2 15858058 1400694 In contrast to the transient activation of ERK by cytokines and growth factors , [PAR-1] stimulation *induces* a sustained activation through its coupling to multiple G-protein linked signaling pathways , including Rho kinase . Positive_regulation F2R ERVK-6 18974154 1983033 The thrombin receptor <[protease> *activated* receptor-1 ( [PAR-1)]] is overexpressed in highly metastatic melanoma cell lines and in patients with metastatic lesions . Positive_regulation F2R ERVK-6 9564545 500734 Receptor activating peptides distinguish [thrombin receptor] ( PAR-1 ) and *mediated* hemodynamic responses in vivo . Positive_regulation F2R F10 11841341 912046 *Activation* of [PAR-1] by thrombin and of PAR-2 by leads to a rapid expression and exposure on the membrane of endothelial cells of both adhesive proteins that mediate an acute inflammatory reaction and of the tissue factor that initiates the blood coagulation cascade . Positive_regulation F2R F2RL1 11841341 912047 *Activation* of [PAR-1] by thrombin and of by factor Xa leads to a rapid expression and exposure on the membrane of endothelial cells of both adhesive proteins that mediate an acute inflammatory reaction and of the tissue factor that initiates the blood coagulation cascade . Positive_regulation F2R F2RL1 11907122 923282 [PAR-1] , PAR-2 , or PAR-4 , in combination , caused additive IL-6 release , but only the PAR-1 and combination *resulted* in an additive IL-8 response . Positive_regulation F2R F2RL1 12372769 996480 *Stimulation* of [PAR-1] with thrombin or by tryptase leads to activation of a membrane associated iPLA(2) and the production of platelet activating factor , arachidonic acid , and PGE ( 2 ) . Positive_regulation F2R F2RL1 20873792 2337246 Agonist GB110 ( 19 , EC ( 50 ) 0.28 µM ) selectively *induced* , but not [PAR1-] , mediated intracellular Ca ( 2+ ) release in HT29 human colorectal carcinoma cells . Positive_regulation F2R F2RL1 24335334 2910840 Both PAR1 and act downstream of COP1 , and COP1 *mediates* the degradation of [PAR1] and PAR2 through the 26S proteasome pathway . Positive_regulation F2R F2RL1 8521491 336425 Analysis of the distribution of PAR-3 and PAR-1 in other par mutants reveals that activity is required for proper localization of PAR-3 and that PAR-3 is *required* for proper localization of [PAR-1] . Positive_regulation F2R F2RL1 8898221 392975 activity is *required* for proper cortical localization of [PAR-1] and this effect requires wild-type par-3 gene activity . Positive_regulation F2R F2RL1 8987167 404123 Both , the activation of the [thrombin receptor] with thrombin or SFLLRN and the *activation* of the with trypsin or SLIGRL induced intracellular calcium mobilisation and a subsequent release of von Willebrand factor (vWf) from Weibel-Palade bodies . Positive_regulation F2R F2RL2 8898221 392976 par-2 activity is required for proper cortical localization of [PAR-1] and this effect *requires* wild-type gene activity . Positive_regulation F2R FADD 15550483 1374887 In endothelial cells transduced with TF to mimic exacerbated TF expression in vascular cells , TF-VIIa-Xa dependent *activation* of [PAR1] remained intact when TF-mediated Xa generation was blocked with 2.5 to 5 nM recombinant TFPI-1 ( rTFPI-1 ) . Positive_regulation F2R FGF2 7955141 277789 [Thrombin receptor] mRNA synthesis was *induced* by both ( maximal stimulation of 1.8-fold at 1 hour ) and platelet derived growth factor ( maximal stimulation of 2.4-fold at 8 and 24 hours ) in quiesced cultured rat aortic smooth muscle cells . Positive_regulation F2R GCK 18567807 1929751 *activates* both [PAR1] and PAR2 , whereas hK2 activates PAR2 . Positive_regulation F2R GNA13 22972936 2678979 [PAR1] *acts* through and Rho GTPase to inhibit the Lats1/2 kinase . Positive_regulation F2R GP1BA 11084032 810040 Altogether these results show that thrombin interaction with *enhances* the specificity of thrombin cleavage of [PAR-1] on intact platelets , suggesting that GpIb may function as a `` cofactor '' for PAR-1 activation by thrombin . Positive_regulation F2R GP1BB 11084032 810041 Altogether these results show that thrombin interaction with *enhances* the specificity of thrombin cleavage of [PAR-1] on intact platelets , suggesting that GpIb may function as a `` cofactor '' for PAR-1 activation by thrombin . Positive_regulation F2R GSK3B 16257959 1489898 directly phosphorylates and *activates* [MARK2/PAR-1] . Positive_regulation F2R GZMA 8058766 268186 released upon stimulation of cytotoxic T lymphocytes *activates* the [thrombin receptor] on neuronal cells and astrocytes . Positive_regulation F2R HRAS 10224146 610071 Co-expression of dominant negative mutants of either Ras or MEK1 with the reporter construct inhibited the thrombin induced PAR-1 expression , whereas constitutively active forms of either or MEK1 *activated* [PAR-1] expression in the absence of thrombin stimulation . Positive_regulation F2R HSP90AA1 11413145 849762 Taken together , these studies demonstrate that may be *essential* for [PAR-1] mediated signaling to the cytoskeleton . Positive_regulation F2R IL6 10343541 616589 [Thrombin receptor] mediated signals *induce* expressions of and granulocyte colony stimulating factor via NF-kappa B activation in synovial fibroblasts . Positive_regulation F2R IL8 16697690 1563820 It was found that HDFs express [PAR-1] and PAR-3 , and thrombin *induces* approximately 7.4-fold increase in secretion from HDFs . Positive_regulation F2R IL8 18657231 2175654 In conclusion , [PAR-1] activation *induces* synthesis by late EPC . Positive_regulation F2R IL8 20570895 2290456 We found that [MMP1-PAR1] activation *induces* the secretion of several angiogenic factors from ovarian carcinoma cells , most prominently , growth regulated oncogene-alpha ( GRO-alpha ) , and monocyte chemoattractant protein-1 . Positive_regulation F2R JUN 12707033 1082776 3 ) [PAR-1] *activation* by thrombin or led to a two-fold increase in cell motility of wounded HT29-D4 . Positive_regulation F2R JUN 9121350 423867 In contrast the [thrombin receptor] , which also couples to phospholipase C , is strongly mitogenic and *induces* dependent gene expression . Positive_regulation F2R KRAS 10224146 610072 Co-expression of dominant negative mutants of either Ras or MEK1 with the reporter construct inhibited the thrombin induced PAR-1 expression , whereas constitutively active forms of either or MEK1 *activated* [PAR-1] expression in the absence of thrombin stimulation . Positive_regulation F2R LAP3 10908720 715624 In conclusion , both [PAR1] and PAR4 *mediate* the effect of viper venom serine on platelets . Positive_regulation F2R LPA 21093894 2376976 Furthermore , MMP-1 and [PAR1] were both significantly *induced* by ( 20 µM ) , and siRNA silencing of MMP-1 and PAR1 both significantly reduced LPA 's invasion promoting effect in DOV13 cells ( p < 0.05 ) . Positive_regulation F2R MAP2K1 10224146 610073 Co-expression of dominant negative mutants of either Ras or MEK1 with the reporter construct inhibited the thrombin induced PAR-1 expression , whereas constitutively active forms of either Ras or *activated* [PAR-1] expression in the absence of thrombin stimulation . Positive_regulation F2R MAPK3 10844601 700580 Thrombin increases mesangial cell HK activity via a PTX-insensitive mechanism involving [thrombin receptor] activation , PKC dependent *activation* of , and both ongoing gene transcription and de novo protein synthesis . Positive_regulation F2R MAPK3 8380983 210190 Differential *activation* of ( ERK1 ) by alpha-thrombin and [thrombin-receptor] peptide agonist . Positive_regulation F2R MIF 14736878 1220135 Moreover , we found that [PAR-1] and PAR-2 mRNA expression in endothelial cells was *enhanced* by . Positive_regulation F2R MMP1 22610965 2614618 In the present study , we hypothesized that ß-AR stimulation would result in *dependent* [PAR1] transactivation in cardiac cells . Positive_regulation F2R MMP10 22610965 2614619 In the present study , we hypothesized that ß-AR stimulation would result in dependent [PAR1] *transactivation* in cardiac cells . Positive_regulation F2R MMP11 22610965 2614620 In the present study , we hypothesized that ß-AR stimulation would result in *dependent* [PAR1] transactivation in cardiac cells . Positive_regulation F2R MMP12 22610965 2614621 In the present study , we hypothesized that ß-AR stimulation would result in dependent [PAR1] *transactivation* in cardiac cells . Positive_regulation F2R MMP13 22610965 2614622 In the present study , we hypothesized that ß-AR stimulation would result in *dependent* [PAR1] transactivation in cardiac cells . Positive_regulation F2R MMP14 22610965 2614623 In the present study , we hypothesized that ß-AR stimulation would result in dependent [PAR1] *transactivation* in cardiac cells . Positive_regulation F2R MMP15 22610965 2614624 In the present study , we hypothesized that ß-AR stimulation would result in *dependent* [PAR1] transactivation in cardiac cells . Positive_regulation F2R MMP16 22610965 2614625 In the present study , we hypothesized that ß-AR stimulation would result in dependent [PAR1] *transactivation* in cardiac cells . Positive_regulation F2R MMP17 22610965 2614626 In the present study , we hypothesized that ß-AR stimulation would result in *dependent* [PAR1] transactivation in cardiac cells . Positive_regulation F2R MMP19 22610965 2614627 In the present study , we hypothesized that ß-AR stimulation would result in dependent [PAR1] *transactivation* in cardiac cells . Positive_regulation F2R MMP2 16202218 1463907 Activation of and -9 *leads* to induction of [proteinase activated receptor-1 (PAR-1)] . Positive_regulation F2R MMP2 22610965 2614628 In the present study , we hypothesized that ß-AR stimulation would result in *dependent* [PAR1] transactivation in cardiac cells . Positive_regulation F2R MMP20 22610965 2614629 In the present study , we hypothesized that ß-AR stimulation would result in dependent [PAR1] *transactivation* in cardiac cells . Positive_regulation F2R MMP21 22610965 2614616 In the present study , we hypothesized that ß-AR stimulation would result in dependent [PAR1] *transactivation* in cardiac cells . Positive_regulation F2R MMP24 22610965 2614630 In the present study , we hypothesized that ß-AR stimulation would result in *dependent* [PAR1] transactivation in cardiac cells . Positive_regulation F2R MMP25 22610965 2614613 In the present study , we hypothesized that ß-AR stimulation would result in *dependent* [PAR1] transactivation in cardiac cells . Positive_regulation F2R MMP26 22610965 2614614 In the present study , we hypothesized that ß-AR stimulation would result in dependent [PAR1] *transactivation* in cardiac cells . Positive_regulation F2R MMP27 22610965 2614615 In the present study , we hypothesized that ß-AR stimulation would result in dependent [PAR1] *transactivation* in cardiac cells . Positive_regulation F2R MMP28 22610965 2614617 In the present study , we hypothesized that ß-AR stimulation would result in *dependent* [PAR1] transactivation in cardiac cells . Positive_regulation F2R MMP3 22610965 2614631 In the present study , we hypothesized that ß-AR stimulation would result in dependent [PAR1] *transactivation* in cardiac cells . Positive_regulation F2R MMP7 22610965 2614632 In the present study , we hypothesized that ß-AR stimulation would result in *dependent* [PAR1] transactivation in cardiac cells . Positive_regulation F2R MMP8 22610965 2614633 In the present study , we hypothesized that ß-AR stimulation would result in dependent [PAR1] *transactivation* in cardiac cells . Positive_regulation F2R MMP9 16202218 1463908 Activation of *leads* to induction of [proteinase activated receptor-1 (PAR-1)] . Positive_regulation F2R MMP9 22610965 2614634 In the present study , we hypothesized that ß-AR stimulation would result in *dependent* [PAR1] transactivation in cardiac cells . Positive_regulation F2R NFATC1 19351910 2088756 Here we show that [PAR-1] activation *induces* binding of both p65/RelA and to the NF-kappaB binding site localized in intron-1 of the ICAM-1 gene to initiate transcription in endothelial cells . Positive_regulation F2R NFATC1 19460777 2115523 This study provides the first evidence that *contributes* to the transcriptional control of [PAR-1] in human VSMC and that PKA dependent NFAT2 inhibition represents a mechanism by which vasodilatory prostaglandins regulate the vascular actions of thrombin . Positive_regulation F2R NFKB1 9199198 438640 This study investigates the *role* of the transcription factor in thrombin- and [thrombin receptor] activating peptide ( TRAP , SFLLRNPNDKYEPYF ) -induced mitogenesis of cultured bovine coronary artery smooth muscle cells (SMC) . Positive_regulation F2R NOX1 11711494 880158 In addition , treatment of cells with antioxidants or an inhibitor *blocked* strain induced [PAR-1] expression . Positive_regulation F2R NOX3 11711494 880159 In addition , treatment of cells with antioxidants or an inhibitor *blocked* strain induced [PAR-1] expression . Positive_regulation F2R NOX4 11711494 880160 In addition , treatment of cells with antioxidants or an inhibitor *blocked* strain induced [PAR-1] expression . Positive_regulation F2R NOX5 11711494 880157 In addition , treatment of cells with antioxidants or an inhibitor *blocked* strain induced [PAR-1] expression . Positive_regulation F2R NRAS 10224146 610074 Co-expression of dominant negative mutants of either Ras or MEK1 with the reporter construct inhibited the thrombin induced PAR-1 expression , whereas constitutively active forms of either or MEK1 *activated* [PAR-1] expression in the absence of thrombin stimulation . Positive_regulation F2R P2RY12 19483102 2107917 We have determined a signaling cascade through [PAR1] , which *involves* phosphatidylinositol ( PI ) kinases , phosphatidylinositol bisphosphate ( PIP ( 2 ) ) , and Rap1 activation ( independent of ) in the formation of a stable platelet aggregate . Positive_regulation F2R PARD3 8521491 336424 Analysis of the distribution of PAR-3 and PAR-1 in other par mutants reveals that par-2 activity is required for proper localization of PAR-3 and that is *required* for proper localization of [PAR-1] . Positive_regulation F2R PARD6A 11516655 851167 Although these PAR proteins therefore seem to play a conserved role in early anterior-posterior polarity in C. elegans and Drosophila , the relationships between them are different , as the localization of [PAR-1] does not *require* Bazooka or in Drosophila , as it does in the worm . Positive_regulation F2R PLA2G4A 7782348 309651 Differential *activation* of by thrombin and [thrombin receptor] agonist peptide in human platelets . Positive_regulation F2R PLG 17122062 1652292 Furthermore , we demonstrated that *activated* [PAR1] and that nicotine induced place preference and dopamine release were diminished in PAR1-deficient (PAR1-/-) mice . Positive_regulation F2R PLG 18384756 1899224 These results suggest that *activates* [PAR-1] and is involved in inflammation in human dental pulp . Positive_regulation F2R PLG 18411702 1894128 Furthermore , *activates* [PAR1] and nicotine induced conditioned place preference and dopamine release are diminished in PAR1-deficient mice . Positive_regulation F2R PLG 18646640 1942297 Furthermore , we demonstrated that *activated* [PAR1] and that nicotine induced place preference and dopamine release were diminished in PAR1-deficient (PAR1-/-) mice . Positive_regulation F2R PLG 19098386 2004023 The expression of PAR(1) on dopaminergic neurons is evident and the *activation* of [PAR(1)] by is demonstrated by assaying GTP-gammaS binding . Positive_regulation F2R PLG 23024298 2694523 In summary , [PAR-1] *activation* by induces PKC mediated phosphorylation of TRPV5 , thereby altering calmodulin-TRPV5 binding , resulting in decreased channel activity . Positive_regulation F2R PLG 23125522 2696312 One possible mechanism of angiostatin 's inhibitory action is that angiostatin suppresses *induced* [PAR-1] activation by competing with plasmin for binding to integrins . Positive_regulation F2R POT1 19483102 2107916 We have determined a signaling cascade through [PAR1] , which *involves* phosphatidylinositol ( PI ) kinases , phosphatidylinositol bisphosphate ( PIP ( 2 ) ) , and activation ( independent of P2Y12 ) in the formation of a stable platelet aggregate . Positive_regulation F2R PROC 21845431 2524252 The receptor [PAR-1] is differentially *activated* by thrombin and the complex , resulting in antithrombotic and anti-inflammatory effects . Positive_regulation F2R PTK2 2153378 127316 Genistein was also able to block the mitogenic effect mediated by thrombin ( IC50 = 20 microM ) although the [thrombin receptor] does not *involve* a activity . Positive_regulation F2R PTK6 2153378 127317 Genistein was also able to block the mitogenic effect mediated by thrombin ( IC50 = 20 microM ) although the [thrombin receptor] does not *involve* a activity . Positive_regulation F2R PTK7 2153378 127318 Genistein was also able to block the mitogenic effect mediated by thrombin ( IC50 = 20 microM ) although the [thrombin receptor] does not *involve* a activity . Positive_regulation F2R RAD50 19483102 2107920 We have determined a signaling cascade through [PAR1] , which *involves* phosphatidylinositol ( PI ) kinases , phosphatidylinositol bisphosphate ( PIP ( 2 ) ) , and activation ( independent of P2Y12 ) in the formation of a stable platelet aggregate . Positive_regulation F2R RELA 19351910 2088757 Here we show that [PAR-1] activation *induces* binding of both and NFATc1 to the NF-kappaB binding site localized in intron-1 of the ICAM-1 gene to initiate transcription in endothelial cells . Positive_regulation F2R RELA 9199198 438641 This study investigates the *role* of the transcription factor in thrombin- and [thrombin receptor] activating peptide ( TRAP , SFLLRNPNDKYEPYF ) -induced mitogenesis of cultured bovine coronary artery smooth muscle cells (SMC) . Positive_regulation F2R RHO 22972936 2678978 [PAR1] *acts* through G(12/13) and GTPase to inhibit the Lats1/2 kinase . Positive_regulation F2R S100A8 19553659 2116972 Our findings reveal that CagA systemically inhibits PAR1 family kinases and indicate that malfunctioning of microtubules and myosin II by *mediated* [PAR1] inhibition cooperates with deregulated SHP-2 in the morphogenetic activity of CagA . Positive_regulation F2R SELE 11458449 838364 Thrombin and [thrombin receptor] agonist peptide *induced* endothelial leukocyte adhesion molecule-1 ( ) expression . Positive_regulation F2R SELL 11458449 838365 Thrombin and [thrombin receptor] agonist peptide *induced* endothelial ( ELAM-1 ) expression . Positive_regulation F2R SERPINE1 9379363 465875 Thrombin and [thrombin receptor] agonist peptide *induced* production of both t-PA and and the elevation of intracellular free calcium concentration ( [ Ca2+ ] i ) . Positive_regulation F2R SETD2 20857420 2375601 However , we observed that thrombin induced increased Twist mRNA and its protein level was *mediated* by the modulation of [PAR-1] activation and the HIF-1a translational pathway . Positive_regulation F2R SNX1 16407403 1527471 Strikingly , depletion of endogenous SNX1 by siRNA markedly inhibited agonist induced PAR1 degradation , whereas expression of a SNX1 siRNA-resistant mutant protein restored agonist promoted PAR1 degradation in cells lacking endogenous SNX1 , indicating that is *necessary* for lysosomal degradation of [PAR1] . Positive_regulation F2R SNX2 16407403 1527472 We further show that , which dimerizes with SNX1 , is not essential for lysosomal sorting of PAR1 , but rather can *regulate* [PAR1] degradation by disrupting endosomal localization of endogenous SNX1 when ectopically expressed . Positive_regulation F2R SPHK1 15626732 1387916 Here , we show that APC enhanced endothelial barrier integrity in a dual-chamber system dependent on binding to endothelial protein C receptor , *activation* of [PAR1] , and activity of cellular . Positive_regulation F2R SPHK1 19162217 2053980 is *essential* for [proteinase activated receptor-1] signalling in epithelial and endothelial cells . Positive_regulation F2R SPHK2 15626732 1387917 Here , we show that APC enhanced endothelial barrier integrity in a dual-chamber system dependent on binding to endothelial protein C receptor , *activation* of [PAR1] , and activity of cellular . Positive_regulation F2R SRC 15383630 1299011 Finally , [PAR1] activation *induces* phosphorylation , which is reversed by using the Src tyrosine kinase inhibitor PP2 , suggesting that Src activation plays a permissive role for PAR1 mediated ERK1/2 activation and cell proliferation probably acting downstream of the EGFR . Positive_regulation F2R STK11 12879020 1115664 Here we show that can *direct* the phosphorylation of the serine-threonine kinase [PAR1A] . Positive_regulation F2R TAOK1 14517247 1147300 , a Ste20-like kinase , *activates* the polarity inducing kinase [MARK/PAR-1] . Positive_regulation F2R TERF1 19483102 2107913 We have determined a signaling cascade through [PAR1] , which *involves* phosphatidylinositol ( PI ) kinases , phosphatidylinositol bisphosphate ( PIP ( 2 ) ) , and activation ( independent of P2Y12 ) in the formation of a stable platelet aggregate . Positive_regulation F2R TERF2 19483102 2107914 We have determined a signaling cascade through [PAR1] , which *involves* phosphatidylinositol ( PI ) kinases , phosphatidylinositol bisphosphate ( PIP ( 2 ) ) , and activation ( independent of P2Y12 ) in the formation of a stable platelet aggregate . Positive_regulation F2R TERF2IP 19483102 2107918 We have determined a signaling cascade through [PAR1] , which *involves* phosphatidylinositol ( PI ) kinases , phosphatidylinositol bisphosphate ( PIP ( 2 ) ) , and activation ( independent of P2Y12 ) in the formation of a stable platelet aggregate . Positive_regulation F2R TFAP2A 24297163 2899052 Thus , *regulates* activated [PAR1] signaling by altering receptor surface expression and through recruitment of RGS proteins . Positive_regulation F2R TINF2 19483102 2107915 We have determined a signaling cascade through [PAR1] , which *involves* phosphatidylinositol ( PI ) kinases , phosphatidylinositol bisphosphate ( PIP ( 2 ) ) , and activation ( independent of P2Y12 ) in the formation of a stable platelet aggregate . Positive_regulation F2R TNFRSF11B 18565131 1972064 Thrombin *induces* synthesis in HPDL cells post-transcriptionally , possibly through [PAR-1] . Positive_regulation F2R TRADD 15550483 1374885 In endothelial cells transduced with TF to mimic exacerbated TF expression in vascular cells , TF-VIIa-Xa *dependent* activation of [PAR1] remained intact when TF-mediated Xa generation was blocked with 2.5 to 5 nM recombinant TFPI-1 ( rTFPI-1 ) . Positive_regulation F2R TRAF2 15550483 1374886 In endothelial cells transduced with TF to mimic exacerbated TF expression in vascular cells , TF-VIIa-Xa dependent *activation* of [PAR1] remained intact when TF-mediated Xa generation was blocked with 2.5 to 5 nM recombinant TFPI-1 ( rTFPI-1 ) . Positive_regulation F2R TYR 1328194 197739 *Stimulation* of the [thrombin receptor] of human glomerular mesangial cells by peptide . Positive_regulation F2R VWF 22952809 2667488 [PAR1] peptide *induced* GEC release to the same extent as PR3 . Positive_regulation F2R VWF 8987167 404122 Both , the activation of the [thrombin receptor] with thrombin or SFLLRN and the activation of the PAR-2 with trypsin or SLIGRL *induced* intracellular calcium mobilisation and a subsequent release of from Weibel-Palade bodies . Positive_regulation F2R WNK1 19351910 2088755 Here we show that [PAR-1] activation *induces* binding of both and NFATc1 to the NF-kappaB binding site localized in intron-1 of the ICAM-1 gene to initiate transcription in endothelial cells . Positive_regulation F2R XIAP 23406164 2781028 *dependent* thrombin generation and the resultant [PAR-1] activation serve as an indispensable mechanism to relay the platelet activation process induced by ADP . Positive_regulation F2RL1 EPHB2 16336275 1491302 Both HAT and [PAR-2 agonist peptide (PAR-2 AP)] *induced* phosphorylation ; Positive_regulation F2RL1 F2R 11841341 912049 *Activation* of by thrombin and of [PAR-2] by factor Xa leads to a rapid expression and exposure on the membrane of endothelial cells of both adhesive proteins that mediate an acute inflammatory reaction and of the tissue factor that initiates the blood coagulation cascade . Positive_regulation F2RL1 F2R 11907122 923283 , PAR-2 , or PAR-4 , in combination , caused additive IL-6 release , but only the PAR-1 and [PAR-2] combination *resulted* in an additive IL-8 response . Positive_regulation F2RL1 F2R 18691294 1949516 Following stimulation of rPer a 7 , the expression of , PAR-2 , PAR-3 and PAR-4 mRNAs on P815 cells increased by 8.7- , 6.8- , 14.4- and 8.8-fold , respectively , following 2- and 6-h incubation periods , and the expression of PAR-1 , [PAR-2] and PAR-4 proteins was *enhanced* following 16-h incubation . Positive_regulation F2RL1 F2R 20873792 2337247 Agonist GB110 ( 19 , EC ( 50 ) 0.28 µM ) selectively *induced* [PAR2-] , but not , mediated intracellular Ca ( 2+ ) release in HT29 human colorectal carcinoma cells . Positive_regulation F2RL1 F2R 24335334 2910841 Both and PAR2 act downstream of COP1 , and COP1 *mediates* the degradation of PAR1 and [PAR2] through the 26S proteasome pathway . Positive_regulation F2RL1 F2R 8987167 404125 Both , the activation of the with thrombin or SFLLRN and the *activation* of the [PAR-2] with trypsin or SLIGRL induced intracellular calcium mobilisation and a subsequent release of von Willebrand factor (vWf) from Weibel-Palade bodies . Positive_regulation F2RL1 IL1B 17339845 1720167 Infection with adenovirus encoding dominant negative IKKbeta ( Ad.IKKbeta ( +/- ) ) and to a lesser extent dominant negative IKKalpha ( Ad.IKKalpha ( +/- ) ) , substantially reduced both control and *induced* expression of both [PAR2] and PAR4 mRNA and enhancement of PAR2 stimulated IP accumulation and Ca ( 2+ ) mobilisation . Positive_regulation F2RL1 IL1B 19247167 2040707 [PAR-2] was expressed by rat IVD cells and in both anulus fibrosus and nucleus pulposus tissues , PAR-2 expression was *up-regulated* by . Positive_regulation F2RL1 IL1B 19247167 2040711 The expression of [PAR-2] is *regulated* by stimulation . Positive_regulation F2RL1 IL1B 19852794 2160440 TGF-beta inhibits *activated* [PAR-2] expression through multiple pathways in human primary synovial cells . Positive_regulation F2RL1 TNF 12636936 1068547 The AELJ ( 100 mg/kg ) also significantly inhibited [PAR2] agonists *induced* myeloperoxidase (MPO) activity and expression in paw tissue . Positive_regulation F2RL1 TNF 17142351 1701009 Flow cytometry for PAR1 , PAR2 , and PAR3 also demonstrated selective [PAR2] upregulation in *response* to and LPS . Positive_regulation F2RL1 TNF 17142351 1701011 *Upregulation* of [PAR2] by heightened HPBF responses to trypsin , while PAR4 induction enabled cathepsin-G mediated calcium signaling . Positive_regulation F2RL3 F2R 16505172 1529300 Platelet aggregation studies demonstrated that [PAR4] activity is markedly *enhanced* by interactions . Positive_regulation F2RL3 F2R 18691294 1949519 Following stimulation of rPer a 7 , the expression of , PAR-2 , PAR-3 and PAR-4 mRNAs on P815 cells increased by 8.7- , 6.8- , 14.4- and 8.8-fold , respectively , following 2- and 6-h incubation periods , and the expression of PAR-1 , PAR-2 and [PAR-4] proteins was *enhanced* following 16-h incubation . Positive_regulation F2RL3 TNF 17142351 1701008 and LPS *induced* [PAR4] mRNA expression ( RT-PCR ) at 6 h and 24 h , respectively . Positive_regulation F3 APOB 17141748 1678656 [Tissue factor] *induction* by aggregated depends on LDL receptor related protein expression ( LRP1 ) and Rho A translocation in human vascular smooth muscle cells . Positive_regulation F3 APOB 7240413 15667 Very low density *induced* a maximal 6.7-fold increase in the expression of a [thromboplastin] activity , which was consistent with tissue factor , in that it was dependent on Factors VII , X , and II . Positive_regulation F3 AVP 21688787 2451562 However , also *induces* V ( 2 ) receptor ( V(2)R ) -mediated antidiuresis , vasodilation , and [coagulation factor] release , all deleterious in septic shock . Positive_regulation F3 CCL2 9353321 461503 [Tissue factor] is *induced* by in human aortic smooth muscle and THP-1 cells . Positive_regulation F3 CSF2 3497933 77888 *induces* [thromboplastin] activity in murine macrophages and human monocytes . Positive_regulation F3 CSF2 3497933 77889 Highly purified *induced* [thromboplastin] activity in murine macrophages and human monocytes in vitro . Positive_regulation F3 CTSB 7635444 317226 Interleukin-1 also upregulates expression and processing of beta-amyloid precursor proteins ( ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 EGF 16113838 1448780 [Tissue factor] is *regulated* by in normal and malignant human endometrial epithelial cells . Positive_regulation F3 F11 8427954 212447 [Tissue factor] ( 1 : 500 ) added to plasma did not *induce* cleavage of during a 90-minute incubation , although fibrin formation within 30 seconds indicated that thrombin was generated via the extrinsic pathway . Positive_regulation F3 F2 3703746 59060 During the course of these studies , the whole blood , *activated* partial [thromboplastin] , and recalcification times for the PAIII bearing animals were similar to those of the control group . Positive_regulation F3 F2RL1 15070680 1232359 [Tissue factor-factor] VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is *mediated* by and results in increased cell migration . Positive_regulation F3 F7 2130929 150676 This article also discusses the *role* of recombinant in the treatment of factor VIII deficiency patients with acquired factor VIII inhibitors , factor VII and ischemic heart disease and the factor VII-phospholipid complex , and the regulation of the [thromboplastin-factor] VIIa complex by factor Xa and extrinsic pathway inhibitor (EPI) . Positive_regulation F3 HGF 12372819 1019632 Unusual proteolytic *activation* of by plasma kallikrein and [coagulation factor] XIa . Positive_regulation F3 HNF4A 16389552 1539869 *Role* of in control of blood [coagulation factor] gene expression . Positive_regulation F3 IL10 7635444 317228 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL11 7635444 317229 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL13 7635444 317230 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL15 7635444 317231 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL16 7635444 317232 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL18 7635444 317233 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL19 7635444 317234 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL1A 3502509 83797 *induces* synthesis of prostacyclin , platelet activating factor , [thromboplastin] and plasminogen activator inhibitor . Positive_regulation F3 IL1A 7676402 326326 [Tissue factor (TF)] can be induced in *response* to stimulation with tumor necrosis factor alpha (TNF-alpha) , and phorbol 12-myristate 13-acetate ( PMA ) . Positive_regulation F3 IL2 2085439 149149 [Tissue factor] *stimulation* by did not correlate with the expression of the IL-2 receptor , Tac , but correlated well with FAB classification of AML cells . Positive_regulation F3 IL2 7635444 317235 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL20 7635444 317236 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL21 7635444 317237 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL22 7635444 317219 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL24 7635444 317217 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL25 7635444 317218 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL26 7635444 317223 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL27 7635444 317224 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL3 7635444 317238 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL31 7635444 317225 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL32 7635444 317222 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL33 7635444 317221 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL34 7635444 317227 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL37 7635444 317220 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL4 7635444 317239 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL5 7635444 317240 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL6 7635444 317241 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL7 7635444 317242 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL8 7635444 317243 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 IL9 7635444 317244 also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , [thromboplastin] , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation F3 LPA 7240413 15668 Very low density induced a maximal 6.7-fold *increase* in the expression of a [thromboplastin] activity , which was consistent with tissue factor , in that it was dependent on Factors VII , X , and II . Positive_regulation F3 LYN 18363812 1912734 [Tissue factor] and IL8 production by P-selectin dependent platelet-monocyte aggregates in whole blood *involves* phosphorylation of and is inhibited by IL10 . Positive_regulation F3 MBL2 20399528 2362808 In this study , we demonstrate that MBL and together *mediate* [coagulation factor-like] activities , including thrombin-like activity . Positive_regulation F3 MBL2 22114968 2514429 Results from our laboratory have demonstrated that and MBL associated serine protease (MASP)-1/3 together *mediate* [coagulation factor-like] activities , including thrombin-like activity . Positive_regulation F3 PLA2G1B 6422935 36961 The stimulation of monocyte [thromboplastin] by endotoxin was *inhibited* in a dose dependent manner by two inhibitors , 4-bromophenacyl bromide and quinacrine , and by two lipoxygenase inhibitors , eicosatetraynoic acid and nordihydroguaiaretic acid . Positive_regulation F3 RETN 20628259 2363052 [Tissue factor] is *induced* by in human coronary artery endothelial cells by the NF-?B dependent pathway . Positive_regulation F3 SELPLG 9198171 438597 [Tissue factor] upregulation on monocytes is *mediated* by and is independent of CD14 , the LPS receptor . Positive_regulation F3 SLC25A10 15091005 1237970 [Tissue factor] was normal on admission but also *increased* with the . Positive_regulation F3 SLC25A10 15389127 1300363 Experimental was *induced* by sustained infusion of 50 mg/kg lipopolysaccharide (LPS) , or 3.75 U/kg [thromboplastin] , for 4 h via the rat tail vein . Positive_regulation F3 TFPI 12028585 947532 [Tissue factor (TF)] is involved in tumor progression and metastatic potency in some malignant tumors and its function is *regulated* by therefore the interaction of both molecules is crucial for their functional role . Positive_regulation F3 TGM1 12193981 981607 [ Blood [coagulation factor] XIII : *activation* , substrates and structure of a ] . Positive_regulation F3 TGM2 12193981 981608 [ Blood [coagulation factor] XIII : *activation* , substrates and structure of a ] . Positive_regulation F3 TGM3 12193981 981609 [ Blood [coagulation factor] XIII : *activation* , substrates and structure of a ] . Positive_regulation F3 TGM4 12193981 981610 [ Blood [coagulation factor] XIII : *activation* , substrates and structure of a ] . Positive_regulation F3 TGM5 12193981 981611 [ Blood [coagulation factor] XIII : *activation* , substrates and structure of a ] . Positive_regulation F3 TGM6 12193981 981612 [ Blood [coagulation factor] XIII : *activation* , substrates and structure of a ] . Positive_regulation F3 TGM7 12193981 981613 [ Blood [coagulation factor] XIII : *activation* , substrates and structure of a ] . Positive_regulation F3 THBD 11940486 928327 This test is based on the coagulation of plasma initiated by [thromboplastin (Tp)] in the *presence* of . Positive_regulation F3 TNF 11149911 780435 [Tissue factor (TF)] has been shown to be *up-regulated* in endothelial cells by the inflammatory cytokine as well as by the main angiogenic factor VEGF . Positive_regulation F3 TNF 8420984 210661 [Tissue factor] is not normally expressed in cells that contact blood , such as endothelial cells and monocytes , but can be *induced* in these cells by or tumor promoting phorbol esters . Positive_regulation F3 TNF 8706889 373514 [Tissue factor] expression on the surface of endothelial cells can be *induced* by and vascular endothelial growth factor ( VEGF ) in a synergistic manner . Positive_regulation F3 VEGFA 11149911 780436 [Tissue factor (TF)] has been shown to be *up-regulated* in endothelial cells by the inflammatory cytokine tumor necrosis factor alpha (TNF-alpha) as well as by the main angiogenic factor . Positive_regulation F3 VEGFA 8706889 373515 [Tissue factor] expression on the surface of endothelial cells can be *induced* by tumor necrosis factor (TNF) and ( VEGF ) in a synergistic manner . Positive_regulation F5 TGM2 12193981 981615 [ Blood [coagulation factor] XIII : *activation* , substrates and structure of a ] . Positive_regulation F7 F3 11150729 758992 *dependent* [factor VIIa] signaling . Positive_regulation F7 F3 11238112 790477 *mediated* endocytosis , recycling , and degradation of [factor VIIa] by a clathrin independent mechanism not requiring the cytoplasmic domain of tissue factor . Positive_regulation F7 F3 11243844 792243 is not *involved* in the mitogenic activity of [factor VIIa] . Positive_regulation F7 F3 1319512 190020 which is undetectable in resting cells appears after exposure to various cytokines and *initiates* [factor VIIa] activation of factors IX and X. Receptors of Factor IX/IXa are also present and mediate the assembly of the prothrombinase complex on the endothelial cell surface . Positive_regulation F7 F3 8407997 233208 , an integral membrane protein , *enhances* the feedback activation of factor VII by [factor VIIa] ( factor VII autoactivation ) . Positive_regulation F7 F3 8768895 378773 , a transmembrane glycoprotein , functions as an essential *activator* of the serine protease [factor VIIa] . Positive_regulation F7 MMP7 22076613 2567984 Tissue factor/activated [factor VIIa] *induces* expression through activation of c-Fos via ERK1/2 and p38 MAPK signaling pathways in human colon cancer cell . Positive_regulation F7 PLAT 10331509 614660 *Activation* of [coagulation factor VII] by . Positive_regulation F7 TGM2 12193981 981622 [ Blood [coagulation factor] XIII : *activation* , substrates and structure of a ] . Positive_regulation F8 PECAM1 11799140 902418 For [Factor VIII] , *allowed* greater discrimination of blood vessels with areas < 25 microm ( 2 ) and demonstrated crisp staining of blood vessels , with minimal background and excellent preservation of tissue architecture . Positive_regulation F8 TGM2 12193981 981629 [ Blood [coagulation factor] XIII : *activation* , substrates and structure of a ] . Positive_regulation F9 EPHB2 19255327 2051133 Based on the pivotal *role* of signaling and vascular endothelial growth factor ( VEGF ) in [papillary thyroid cancer (PTC)] , we conducted a phase II clinical trial of sorafenib targeting RAF and VEGF receptor kinases in PTC . Positive_regulation F9 F2R 16752917 1571139 *stimulated* [factor IXa] binding to a small platelet subpopulation requires a pronounced and sustained increase of cytoplasmic calcium . Positive_regulation F9 F2R 16752917 1571140 While fluorescence changes in all platelets indicated calcium release from internal stores and influx of external calcium , a subpopulation of platelets displayed a pronounced increase in calcium transients by 15 s and positive factor IXa binding by 2 min , with calcium transients sustained for 45 min. Pretreatment of platelets with Xestospongin C to inhibit IP3 mediated dense tubule calcium release , and the presence of impermeable calcium channel blockers nifedipine , SKF96365 , or LaCl3 , inhibited *induced* development of a subpopulation with pronounced calcium transients , [factor IXa] binding , and platelet support of FXa generation , suggesting the importance of both release of calcium from internal stores and influx of extracellular calcium . Positive_regulation F9 JAG1 21215732 2386348 These results suggest that the amygdala to vlPAG pathway may be a critical element of the expanded seizure network that contributes importantly to the emergence of [PTC] *induced* by kindling in GEPR-9s , which is supported by recent preliminary studies of this pathway . Positive_regulation F9 TGM2 12193981 981636 [ Blood [coagulation factor] XIII : *activation* , substrates and structure of a ] . Positive_regulation F9 TNF 15574511 1355709 This hypothesis was examined further by *stimulation* of [PTC] ICAM expression by . Positive_regulation FABP1 FOXA1 23318274 2746701 The human liver fatty acid binding protein ( [FABP1] ) gene is *activated* by and PPARa ; Positive_regulation FABP3 IL1B 10477831 643351 Neither TNF-alpha nor *had* any significant effect on [H-FABP] mRNA expression in heart and muscle . Positive_regulation FABP3 TNF 10477831 643350 Neither nor IL-1beta *had* any significant effect on [H-FABP] mRNA expression in heart and muscle . Positive_regulation FABP4 EPHB2 24075747 2847569 Akt and activation by PUFA oxidation derived aldehydes *upregulates* [FABP4] expression in human macrophages . Positive_regulation FABP4 FOXO1 20102700 2213040 Metformin reduces lipid accumulation in macrophages by inhibiting *mediated* transcription of [fatty acid binding protein 4] . Positive_regulation FADD EPHB2 12122017 984989 Head involution defective ( Hid ) -triggered apoptosis requires caspase-8 but not [FADD] ( Fas associated death domain ) and is *regulated* by in mammalian cells . Positive_regulation FADD EPHB2 19758790 2183420 Marked concomitant increases in the content of [p-FADD] ( 48 % ) and the *activation* of ( 46-79 % ) were quantified during the short-term expression of morphine sensitization ( SW 3 , in the absence of morphine challenge ) . Positive_regulation FADD EPHB2 8876175 390326 Serum response factor dependent [ternary complex] formation by Sap1a is *stimulated* by phosphorylation but not by SAPK/JNKs . Positive_regulation FADD FAS 11003656 734761 HSP27 expression had no effect on *induced* [FADD-] and caspase dependent apoptosis . Positive_regulation FADD FAS 15017386 1257098 Interestingly , mitogenic stimulation , but not ligation , *induced* a unique post-translational modification of [FADD] . Positive_regulation FADD FAS 15214041 1262841 Similarly , cross linking *resulted* in caspase independent translocation of [FADD/MORT1] and caspase-8 to the lipid rafts , which was prevented by a death domain-defective receptor . Positive_regulation FADD FAS 19969555 2199630 Further studies demonstrated theaflavin *induced* upregulation through the activation of c-jun N-terminal kinase , [Fas-FADD] interaction in a Fas ligand independent manner , caspase-8 activation and t-Bid formation . Positive_regulation FADD FAS 23285096 2711752 However , GTP induced upregulation through activation of c-jun-N-terminal kinase *resulted* in [FADD] phosphorylation , caspase-8 activation and truncation of BID , leading to apoptosis in both LNCaPshV and LNCaPshp53 cells . Positive_regulation FADD FAS 23606538 2778755 signaling strongly *induced* the phosphorylation of [FADD] at Ser ( 194 ) and Pin1 at Ser ( 16 ) , as well as their nuclear accumulation . Positive_regulation FADD FUT4 17410536 1736354 *induced* activation of [Fas associated death domain (FADD)] and caspase-8 was suppressed by RNA interference mediated inhibition of TNFR1 expression . Positive_regulation FADD ITGB2 9867833 583007 This interaction may *promote* ( Mac1p ) 2.DNA [ternary complex] formation at Mac1p-responsive upstream activating sequences . Positive_regulation FADD MAP2K6 19758790 2183426 Marked concomitant increases in the content of [p-FADD] ( 48 % ) and the *activation* of ( 46-79 % ) were quantified during the short-term expression of morphine sensitization ( SW 3 , in the absence of morphine challenge ) . Positive_regulation FADD TNF 10599977 573796 These results suggest that can *cause* apoptosis in pancreatic beta cells through TNFR1 linked apoptotic factors , TRADD , [FADD] , and FLICE , and TNF induced ceramide production may be involved in the pathways . Positive_regulation FADD TNF 16924232 1692191 *induced* the expression of NF-kappaB regulated gene products cyclin D1 , c-Myc , matrix metalloproteinase-9 , survivin , X-linked inhibitor-of-apoptosis protein ( IAP ) , IAP1 , Bcl-x ( L ) , A1/Bfl-1 and [Fas associated death domain protein-like] IL-1beta converting enzyme-inhibitory protein in wild-type MEF but not in PKR-/- cells . Positive_regulation FADD TNF 20564232 2290301 Immunoprecipitation studies revealed associations of NM IIB with clathrin , [FADD] , and caspase 8 in *response* to suggesting a role for NM IIB in TNFR1 endocytosis and the formation of the death inducing signaling complex (DISC) . Positive_regulation FADD TNF 21620750 2454482 Sam68 is also found as a part of the *induced* cytoplasmic [caspase-8-FADD] complex . Positive_regulation FADD TNFSF10 19935877 2167549 Interestingly , in the *presence* of , it increased caspase-8 binding to the [Fas associated death domain (FADD)] , but decreased binding of FADD-like interleukin-1beta converting enzyme inhibitory proteins ( FLIPs ) . Positive_regulation FAIM2 EPHB2 23029562 2681053 *mediated* activation of [Fas apoptotic inhibitory molecule 2] ( Faim2 ) prevents apoptosis of 661W cells in a model of detachment induced photoreceptor cell death . Positive_regulation FAIM2 EPHB2 23029562 2681068 The expression of [Faim2] is *triggered* , at least in part , by Fas-receptor activation and subsequent signaling . Positive_regulation FAIM2 FAS 23029562 2681067 The expression of [Faim2] is *triggered* , at least in part , by activation and subsequent ERK signaling . Positive_regulation FAIM3 FAS 19414556 2075449 These proteins also inhibit inflammatory cell apoptosis/cell death while inhibiting expression , activating protein kinase B/AKT , and *inducing* [Faim 3] . Positive_regulation FAM3B FOXO1 21412813 2432106 Moreover , overexpression *increased* [PANDER] expression in cultured hepatocytes and mouse livers . Positive_regulation FANCC TNF 19168785 2048994 Importantly , hematopoietic progenitor assays demonstrated that JNK inhibition enhanced [Fancc] ( -/- ) colony formation in the *presence* of . Positive_regulation FAP CLU 22512538 2601996 Overall , our results allow us to postulate a putative protective *role* of in [FAP] , namely in the modulation of TTR aggregate formation . Positive_regulation FAP CLU 22512538 2601999 Future experiments are required to clarify the *role* of in [FAP] . Positive_regulation FARP2 TNF 19276662 2079766 Like-wise , [FIR] *induced* the expression of IAP1 , IAP2 , XIAP Survivin , MnSOD , , pAKT and IL-1alpha . Positive_regulation FAS ABCC6 10226543 610403 *induced* a slight but consistent increase in the expression of [Fas] antigen on the treated cells . Positive_regulation FAS ABCC6 15138577 1246212 Remarkably , omega-6 PUFAs linoleic acid ( LA ) and , suppressors of both hepatic and adipocytic FAS dependent lipogenesis , *had* no significant inhibitory effects on the activity of tumor associated [FAS] in SK-Br3 breast cancer cells . Positive_regulation FAS ACD 11809811 906837 On the other hand , activation could *restore* [FAs] in cells expressing FA-Csk. Activation of the executioner caspase , caspase 3 , is essential for many forms of apoptosis . Positive_regulation FAS ACP2 9637071 513630 Compared to the isoform ACP 1 , was more effective in supporting the synthesis of such fatty acids in the FAS reaction of rape seed extracts and *caused* a higher accumulation of [FAS] products in all experiments . Positive_regulation FAS ADD1 11463364 839183 Using adenoviral overexpression of a dominant negative form of adipocyte determination and differentiation factor 1 ( ADD1 ) , a transcription factor that binds to the insulin-responsive E box , we demonstrated that was *required* for Ang II regulation of the [FAS] gene in 3T3-L1 adipocytes . Positive_regulation FAS AKT1 14967838 1220249 Here , we report that [Fas] engagement with Fas ligand *induced* activation of and upregulation of endothelial nitric oxide synthase expression without induction of apoptosis . Positive_regulation FAS AKT1 15806173 1417501 Collectively , our findings are consistent with a working model in which activation *regulates* [FAS] expression , at least in part , whereas FAS activity modulates AKT activation . Positive_regulation FAS AKT1 21392090 2401021 The cytotoxic effect and the increase in [Fas] and Fas L were *dependent* on activation . Positive_regulation FAS AKT1 9738010 531730 Furthermore , cotransfected wild-type *increased* [FAS] promoter activity in the absence of insulin and a loss of insulin responsiveness of the FAS promoter . Positive_regulation FAS AKT2 14967838 1220250 Here , we report that [Fas] engagement with Fas ligand *induced* activation of and upregulation of endothelial nitric oxide synthase expression without induction of apoptosis . Positive_regulation FAS AKT2 15806173 1417502 Collectively , our findings are consistent with a working model in which activation *regulates* [FAS] expression , at least in part , whereas FAS activity modulates AKT activation . Positive_regulation FAS AKT2 21392090 2401022 The cytotoxic effect and the increase in [Fas] and Fas L were *dependent* on activation . Positive_regulation FAS AKT2 9738010 531731 Furthermore , cotransfected wild-type *increased* [FAS] promoter activity in the absence of insulin and a loss of insulin responsiveness of the FAS promoter . Positive_regulation FAS AKT3 14967838 1220251 Here , we report that [Fas] engagement with Fas ligand *induced* activation of and upregulation of endothelial nitric oxide synthase expression without induction of apoptosis . Positive_regulation FAS AKT3 15806173 1417503 Collectively , our findings are consistent with a working model in which activation *regulates* [FAS] expression , at least in part , whereas FAS activity modulates AKT activation . Positive_regulation FAS AKT3 21392090 2401023 The cytotoxic effect and the increase in [Fas] and Fas L were *dependent* on activation . Positive_regulation FAS AKT3 9738010 531732 Furthermore , cotransfected wild-type *increased* [FAS] promoter activity in the absence of insulin and a loss of insulin responsiveness of the FAS promoter . Positive_regulation FAS ANGPT1 15763944 1352564 Interestingly , the DOX induced up-regulation in Fas ( CD95/APO-1 ) and Fas ligand expression could be blocked by Ang-1 , indicating a pivotal *role* of in DOX induced [Fas] and Fas ligand expression . Positive_regulation FAS ANGPT2 10325958 612827 The presence of ( 0.3 microM ) further *enhanced* these effects of anoxia-reoxygenation on cNOS , [Fas] and bcl-2 expression . Positive_regulation FAS ANGPT2 11463364 839187 In conclusion , this is the first report that *regulates* adipocyte [FAS] gene transcription via insulin response sequences in a glucose dependent manner and that this regulation is mediated at least in part via the ADD1 transcription factor . Positive_regulation FAS ANGPT2 12527553 1071027 also *enhanced* RPTEC expression of [Fas] and Fas ligand (FasL) ; Positive_regulation FAS ANXA6 21479379 2009691 SOCS1 silencing in DCs could prevent immune tolerance by inhibiting [Fas] and Fas-L expression , *induced* by an increase in and IL-6 production . Positive_regulation FAS APC 16902496 1692094 In short-term assays , [m-CD95L] expressing *induced* apoptosis in activated T cells and the constitutive presence of m-CD95L and HLA-A1 expressing APC in long-term T cell cultures prevented the expansion of CD4 ( + ) and CD8 ( + ) HLA-A1-specific T cells and the development of HLA-A1-specific cytotoxicity . Positive_regulation FAS APCS 18820644 1987673 Taken together , these results indicate that can *regulate* T-cell levels of [CD95L] by releasing PGE ( 2 ) in response to LPS through a TLR4/MyD88 dependent pathway , with consequences for both T cell and their own survival . Positive_regulation FAS APOB 12419941 1013295 Flow cytometry demonstrated that dose-dependently *up-regulated* cell surface [Fas] expression . Positive_regulation FAS APOB 20036856 2192497 Electronegative *induces* [Fas] and modifies gene expression in mononuclear cells . Positive_regulation FAS APOB 20036856 2192499 ( - ) down-regulated CD36 and colony stimulating factor 1 receptor ( CSF1R ) genes and *up-regulated* [Fas] expression and Fas protein on cellular membrane . Positive_regulation FAS APOB 21602495 2441760 The results indicate that prominent brain endothelial cell apoptosis occurs during relapsing remitting bacteremia in the absence of IL-10 and point to a prominent role for bacterial mediated *activation* of [FAS] and caspase-3 in this process . Positive_regulation FAS APOB 9683446 522008 further *increased* [Fas] expression and decreased bcl-2 expression . Positive_regulation FAS ARAP2 17077126 1642352 In agreement with the hypothesis that ARAP2 mediates effects of RhoA , endogenous associated with focal adhesions (FAs) and reduction of ARAP2 expression , by RNAi , *resulted* in fewer [FAs] and actin stress fibers ( SFs ) . Positive_regulation FAS ARF1 15207713 1261653 The finding that Adp14ARF infection did not induce Fas expression in U2OS/E6 and MCF/E6 cells suggests that wild type p53 expression may be necessary for mediated *induction* of [Fas] . Positive_regulation FAS ARF3 15207713 1261654 The finding that Adp14ARF infection did not induce Fas expression in U2OS/E6 and MCF/E6 cells suggests that wild type p53 expression may be necessary for *mediated* induction of [Fas] . Positive_regulation FAS ARF4 15207713 1261655 The finding that Adp14ARF infection did not induce Fas expression in U2OS/E6 and MCF/E6 cells suggests that wild type p53 expression may be necessary for mediated *induction* of [Fas] . Positive_regulation FAS ARF5 15207713 1261656 The finding that Adp14ARF infection did not induce Fas expression in U2OS/E6 and MCF/E6 cells suggests that wild type p53 expression may be necessary for *mediated* induction of [Fas] . Positive_regulation FAS ARF6 15207713 1261657 The finding that Adp14ARF infection did not induce Fas expression in U2OS/E6 and MCF/E6 cells suggests that wild type p53 expression may be necessary for mediated *induction* of [Fas] . Positive_regulation FAS ARG1 7493965 335715 When HepG2 cells were fed serum-free media selectively deficient in each amino acid , the omission of any single classic essential amino acid as well as or His ( essential in some rapidly growing cells ) *resulted* in [FAS] mRNA levels that were about half of those in complete medium . Positive_regulation FAS ARG2 7493965 335716 When HepG2 cells were fed serum-free media selectively deficient in each amino acid , the omission of any single classic essential amino acid as well as or His ( essential in some rapidly growing cells ) *resulted* in [FAS] mRNA levels that were about half of those in complete medium . Positive_regulation FAS BANF1 11897677 921458 Activation of the transcription nuclear factor-kappa B (NF-kappa B) is required for PIC induced inducible nitric oxide synthase expression in beta-cells , and we hypothesized that this transcription factor may also participate in *induced* [Fas] expression and beta-cell apoptosis . Positive_regulation FAS BANF1 11897677 921472 Site directed mutations at the NF-kappa B and CCAAT/enhancer binding protein binding sites prevented *induced* [Fas] promoter activity . Positive_regulation FAS BARD1 18514188 1922498 Genistein inhibits estrogen receptor-alpha and activates in BRCA1 blocked cells and *induces* estrogen receptor-beta and [FAS] in presence of BRCA1 . Positive_regulation FAS BAX 15685630 1370984 Modest [Fas] staining with no obvious change was *detected* throughout the menstrual cycle , while the levels of FasL and protein in the epithelial cells increased in the secretory phase when apoptosis was most prevalent . Positive_regulation FAS BAX 18373696 1898902 These results indicate that the JNK-c-Jun pathway is required for the transcriptional upregulation of [Fas] and subsequent *activation* of and Bak , and that JNK , but not c-Jun , is directly associated with phosphorylation and downregulation of Bcl-2 in response to ionizing radiation . Positive_regulation FAS BAX 22419868 2572812 In this study , we demonstrated that combined treatment with TiO ( 2 ) nanoparticles sized less than 100 nm and ultraviolet A irradiation induces apoptotic cell death through reactive oxygen species dependent upregulation of [Fas] and conformational *activation* of in normal human cells . Positive_regulation FAS BCL10 9452459 484141 To test this hypothesis a cell line in which [CD95] signaling was *inhibited* by overexpression of was used . Positive_regulation FAS BCL2 11458390 838356 Bax and [Fas] , proapoptotic proteins , were *detected* homogeneously throughout both ventricles in the neonate , while , an antiapoptotic protein , was not detectable . Positive_regulation FAS BCL2 21425578 2406145 As compared with the control group , after toosendanin treatment , expression of decreased , and that of Bax and [Fas] *increased* in SMMC-7721 cells ; Positive_regulation FAS BCL2 9452459 484142 To test this hypothesis a cell line in which [CD95] signaling was *inhibited* by overexpression of was used . Positive_regulation FAS BCL3 9452459 484143 To test this hypothesis a cell line in which [CD95] signaling was *inhibited* by overexpression of was used . Positive_regulation FAS BCL5 9452459 484138 To test this hypothesis a cell line in which [CD95] signaling was *inhibited* by overexpression of was used . Positive_regulation FAS BCL6 9452459 484139 To test this hypothesis a cell line in which [CD95] signaling was *inhibited* by overexpression of was used . Positive_regulation FAS BCL9 9452459 484140 To test this hypothesis a cell line in which [CD95] signaling was *inhibited* by overexpression of was used . Positive_regulation FAS BCR 23519466 2777239 We found previously that expression of the CML related oncoprotein in myeloid progenitor cells *increases* expression of [Fas associated phosphatase 1 (Fap1)] . Positive_regulation FAS BID 10713706 676262 We provide evidence that both , radiation and [CD95] stimulation , *induce* the rapid activation of caspase-8 and followed by apoptosis in Jurkat T-cells . Positive_regulation FAS BRCA1 18514188 1922497 Genistein inhibits estrogen receptor-alpha and activates BARD1 in BRCA1 blocked cells and induces estrogen receptor-beta and [FAS] in *presence* of . Positive_regulation FAS CA2 11160247 781559 We have previously reported that [CD95L] expression *requires* both protein kinase C ( PKC ) translocation and mobilization and is inhibited by cyclosporin A , and dexamethasone . Positive_regulation FAS CA2 9529322 496614 These results further define the *role* of in perforin and [FasL/Fas] killing and demonstrate that differential Ca2+ signaling can modulate T cell effector functions . Positive_regulation FAS CALM3 14578204 1156664 Although a broad-range caspase inhibitor partially blocked CaM antagonist mediated apoptosis , the neutralizing Fas antibody had no effect , suggesting that antagonist mediated apoptosis does not *require* interaction between CaM antagonists and surface [Fas] . Positive_regulation FAS CALM3 23760276 2820156 Previous studies have shown that calmodulin (CaM) is recruited into the DISC in cholangiocarcinoma cells , suggesting a novel *role* of in [Fas] mediated signaling . Positive_regulation FAS CALML3 17591956 1764555 Here , we report that although [Fas] expression on splenocytes and hepatocytes is *up-regulated* by and is inhibited by in vivo short interfering RNA , FasL as well as the frequency of CD8 ( + ) T cells are differentially altered by sepsis in the spleen ( no change in FasL , decreased percentage of CD8 ( + ) and CD4 ( + ) T cells ) versus the liver ( increased FasL expression on CD8 ( + ) T cells and increase in percentage/number ) . Positive_regulation FAS CALML3 22635047 2625535 TLR3 deficiency significantly decreased CLP induced cardiac-myocyte apoptosis and attenuated *induced* [Fas] and Fas ligand expression in the myocardium . Positive_regulation FAS CASP1 10391681 626696 [Fas] ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation FAS CASP1 10602493 574828 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Positive_regulation FAS CASP1 11334117 809197 [Fas-ligation] *induced* upregulation of and -3 expression in the nucleus and cytoplasm in A549 cells . Positive_regulation FAS CASP1 12605597 1079464 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block [Fas-] and etoposide *induced* activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation FAS CASP1 13677932 1140088 We examined whether a broad-range inhibitor ( C.I. ) can *inhibit* the [Fas] expression enhanced by LD-anticancer drugs . Positive_regulation FAS CASP1 13677932 1140101 However , the [Fas] expression enhanced by LD-ara-C or LD-VP-16 was not *inhibited* by a broad-range inhibitor . Positive_regulation FAS CASP1 16646028 1557163 [Fas] stimulation activated NF-kappaB and AP-1 , and this response *required* activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation FAS CASP1 16646028 1557296 [Fas] proinflammatory signaling is *dependent* upon activity and FLIP expression . Positive_regulation FAS CASP1 18386902 1907122 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , activation , and [Fas] *induction* . Positive_regulation FAS CASP1 19111607 2031747 However , recent studies have shown that [Fas] can *induce* nonapoptotic when caspase activity is inhibited . Positive_regulation FAS CASP1 20138036 2213625 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Positive_regulation FAS CASP1 20138036 2213665 Here we describe the fate of Fas downstream of the FasL induced internalization step , including formation of *dependent* SDS-stable [Fas] complexes , which is mediated by cytoskeleton integrity . Positive_regulation FAS CASP1 23530784 2762282 Various methods to inhibit apoptosis including the cell surface [Fas] receptor pathway *inhibitors* , inhibitors , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation FAS CASP1 8840958 386870 Specific tetrapeptide inhibitors of ( Acetyl-Tyr-Val-Ala-Asp-chloromethylketone ) or CPP32beta ( Acetyl-Asp-Glu-Val-Asp-aldehyde ) *prevented* the [anti-Fas] antibody mediated activation of p34cdc2 and inhibited apoptosis . Positive_regulation FAS CASP1 9045686 416373 Fas associated death domain protein 2 ( FLICE2 ) , an ICE/Ced-3 homologue , is proximally *involved* in [CD95-] and p55 mediated death signaling . Positive_regulation FAS CASP10 10391681 626697 [Fas] ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation FAS CASP10 10602493 574829 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Positive_regulation FAS CASP10 12605597 1079465 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block [Fas-] and etoposide *induced* activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation FAS CASP10 13677932 1140089 We examined whether a broad-range inhibitor ( C.I. ) can *inhibit* the [Fas] expression enhanced by LD-anticancer drugs . Positive_regulation FAS CASP10 13677932 1140102 However , the [Fas] expression enhanced by LD-ara-C or LD-VP-16 was not *inhibited* by a broad-range inhibitor . Positive_regulation FAS CASP10 16646028 1557164 [Fas] stimulation activated NF-kappaB and AP-1 , and this response *required* activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation FAS CASP10 16646028 1557297 [Fas] proinflammatory signaling is *dependent* upon activity and FLIP expression . Positive_regulation FAS CASP10 18386902 1907123 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , activation , and [Fas] *induction* . Positive_regulation FAS CASP10 19111607 2031748 However , recent studies have shown that [Fas] can *induce* nonapoptotic when caspase activity is inhibited . Positive_regulation FAS CASP10 20138036 2213626 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Positive_regulation FAS CASP10 20138036 2213666 Here we describe the fate of Fas downstream of the FasL induced internalization step , including formation of *dependent* SDS-stable [Fas] complexes , which is mediated by cytoskeleton integrity . Positive_regulation FAS CASP10 23530784 2762283 Various methods to inhibit apoptosis including the cell surface [Fas] receptor pathway *inhibitors* , inhibitors , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation FAS CASP12 10391681 626707 [Fas] ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation FAS CASP12 10602493 574839 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Positive_regulation FAS CASP12 12605597 1079475 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block [Fas-] and etoposide *induced* activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation FAS CASP12 13677932 1140099 We examined whether a broad-range inhibitor ( C.I. ) can *inhibit* the [Fas] expression enhanced by LD-anticancer drugs . Positive_regulation FAS CASP12 13677932 1140112 However , the [Fas] expression enhanced by LD-ara-C or LD-VP-16 was not *inhibited* by a broad-range inhibitor . Positive_regulation FAS CASP12 16646028 1557174 [Fas] stimulation activated NF-kappaB and AP-1 , and this response *required* activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation FAS CASP12 16646028 1557307 [Fas] proinflammatory signaling is *dependent* upon activity and FLIP expression . Positive_regulation FAS CASP12 18386902 1907133 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , activation , and [Fas] *induction* . Positive_regulation FAS CASP12 19111607 2031758 However , recent studies have shown that [Fas] can *induce* nonapoptotic when caspase activity is inhibited . Positive_regulation FAS CASP12 20138036 2213636 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Positive_regulation FAS CASP12 20138036 2213676 Here we describe the fate of Fas downstream of the FasL induced internalization step , including formation of *dependent* SDS-stable [Fas] complexes , which is mediated by cytoskeleton integrity . Positive_regulation FAS CASP12 23530784 2762293 Various methods to inhibit apoptosis including the cell surface [Fas] receptor pathway *inhibitors* , inhibitors , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation FAS CASP14 10391681 626698 [Fas] ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation FAS CASP14 10602493 574830 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Positive_regulation FAS CASP14 12605597 1079466 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block [Fas-] and etoposide *induced* activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation FAS CASP14 13677932 1140090 We examined whether a broad-range inhibitor ( C.I. ) can *inhibit* the [Fas] expression enhanced by LD-anticancer drugs . Positive_regulation FAS CASP14 13677932 1140103 However , the [Fas] expression enhanced by LD-ara-C or LD-VP-16 was not *inhibited* by a broad-range inhibitor . Positive_regulation FAS CASP14 16646028 1557165 [Fas] stimulation activated NF-kappaB and AP-1 , and this response *required* activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation FAS CASP14 16646028 1557298 [Fas] proinflammatory signaling is *dependent* upon activity and FLIP expression . Positive_regulation FAS CASP14 18386902 1907124 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , activation , and [Fas] *induction* . Positive_regulation FAS CASP14 19111607 2031749 However , recent studies have shown that [Fas] can *induce* nonapoptotic when caspase activity is inhibited . Positive_regulation FAS CASP14 20138036 2213627 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Positive_regulation FAS CASP14 20138036 2213667 Here we describe the fate of Fas downstream of the FasL induced internalization step , including formation of *dependent* SDS-stable [Fas] complexes , which is mediated by cytoskeleton integrity . Positive_regulation FAS CASP14 23530784 2762284 Various methods to inhibit apoptosis including the cell surface [Fas] receptor pathway *inhibitors* , inhibitors , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation FAS CASP16 10391681 626708 [Fas] ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation FAS CASP16 10602493 574840 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Positive_regulation FAS CASP16 12605597 1079477 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block [Fas-] and etoposide *induced* activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation FAS CASP16 13677932 1140100 We examined whether a broad-range inhibitor ( C.I. ) can *inhibit* the [Fas] expression enhanced by LD-anticancer drugs . Positive_regulation FAS CASP16 13677932 1140113 However , the [Fas] expression enhanced by LD-ara-C or LD-VP-16 was not *inhibited* by a broad-range inhibitor . Positive_regulation FAS CASP16 16646028 1557175 [Fas] stimulation activated NF-kappaB and AP-1 , and this response *required* activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation FAS CASP16 16646028 1557308 [Fas] proinflammatory signaling is *dependent* upon activity and FLIP expression . Positive_regulation FAS CASP16 18386902 1907134 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , activation , and [Fas] *induction* . Positive_regulation FAS CASP16 19111607 2031759 However , recent studies have shown that [Fas] can *induce* nonapoptotic when caspase activity is inhibited . Positive_regulation FAS CASP16 20138036 2213637 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Positive_regulation FAS CASP16 20138036 2213677 Here we describe the fate of Fas downstream of the FasL induced internalization step , including formation of *dependent* SDS-stable [Fas] complexes , which is mediated by cytoskeleton integrity . Positive_regulation FAS CASP16 23530784 2762294 Various methods to inhibit apoptosis including the cell surface [Fas] receptor pathway *inhibitors* , inhibitors , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation FAS CASP2 10391681 626699 [Fas] ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation FAS CASP2 10602493 574831 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Positive_regulation FAS CASP2 10616904 575853 [Fas] *activation* of , caspase-3 , caspase-7 , and caspase-8 and the proteolytic cleavage of substrates such as BID , protein kinase Cdelta , and poly ( ADP-ribose ) polymerase were completely defective in the FADD mutant cell lines . Positive_regulation FAS CASP2 12605597 1079467 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block [Fas-] and etoposide *induced* activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation FAS CASP2 13677932 1140091 We examined whether a broad-range inhibitor ( C.I. ) can *inhibit* the [Fas] expression enhanced by LD-anticancer drugs . Positive_regulation FAS CASP2 13677932 1140104 However , the [Fas] expression enhanced by LD-ara-C or LD-VP-16 was not *inhibited* by a broad-range inhibitor . Positive_regulation FAS CASP2 15345335 1292175 These events were accompanied by a marked increase of [Fas] protein expression , and *activation* of , -3 , -8 . Positive_regulation FAS CASP2 16646028 1557166 [Fas] stimulation activated NF-kappaB and AP-1 , and this response *required* activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation FAS CASP2 16646028 1557299 [Fas] proinflammatory signaling is *dependent* upon activity and FLIP expression . Positive_regulation FAS CASP2 18386902 1907125 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , activation , and [Fas] *induction* . Positive_regulation FAS CASP2 19111607 2031750 However , recent studies have shown that [Fas] can *induce* nonapoptotic when caspase activity is inhibited . Positive_regulation FAS CASP2 20138036 2213628 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Positive_regulation FAS CASP2 20138036 2213668 Here we describe the fate of Fas downstream of the FasL induced internalization step , including formation of *dependent* SDS-stable [Fas] complexes , which is mediated by cytoskeleton integrity . Positive_regulation FAS CASP2 23530784 2762285 Various methods to inhibit apoptosis including the cell surface [Fas] receptor pathway *inhibitors* , inhibitors , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation FAS CASP3 10391681 626700 [Fas] ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation FAS CASP3 10602493 574832 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Positive_regulation FAS CASP3 10811113 692991 Cell death was accompanied by an increase in DNA binding activity of the transcription factor AP-1 , *transactivation* of the AP-1 site containing [CD95L] promoter , and protease activation . Positive_regulation FAS CASP3 10845905 700692 IFN-gamma induced Fas expression of the cells without the activation of caspase8 or caspase3 during 16 hours of incubation , while deprivation of EPO induced expression of [Fas] and the *activation* of both caspase8 and . Positive_regulation FAS CASP3 11000584 734527 These results indicate that anticancer drugs and gamma-rays prime squamous cell carcinoma cells to be susceptible to apoptosis by LAK cells , that LAK cell induced apoptosis largely depends on the *activation* of by the [Fas/Fas-ligand] signal and granzyme B , and that LAK cells induce ROI in the target cells , which is largely mediated by Fas and granzyme B . Positive_regulation FAS CASP3 11334117 809198 [Fas-ligation] *induced* upregulation of expression in the nucleus and cytoplasm in A549 cells . Positive_regulation FAS CASP3 11441079 833395 The ICAM-1 mediated costimulatory signals in this model resulted in early Th cell proliferation followed by cell death that was partially mediated by [Fas] and *involved* loss of mitochondrial membrane potential , processing of procaspase-9 and -3 , and activation of . Positive_regulation FAS CASP3 12354208 993513 Results demonstrated up-regulation of [Fas] and *activation* of in T cells in response to A. actinomycetemcomitans CFCS . Positive_regulation FAS CASP3 12605597 1079468 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block [Fas-] and etoposide *induced* activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation FAS CASP3 12925221 1131253 Lomefloxacin could also lead to apoptosis in keratinocytes exposed to ultraviolet A : was activated and [FAS-L] gene was *induced* . Positive_regulation FAS CASP3 13677932 1140092 We examined whether a broad-range inhibitor ( C.I. ) can *inhibit* the [Fas] expression enhanced by LD-anticancer drugs . Positive_regulation FAS CASP3 13677932 1140105 However , the [Fas] expression enhanced by LD-ara-C or LD-VP-16 was not *inhibited* by a broad-range inhibitor . Positive_regulation FAS CASP3 15144569 1247580 After HuIFN-beta exposure , COH and CC-M2 cells showed increased levels of [Fas] and FasL proteins , alteration of mitochondrial membrane potential , and *activation* of caspase-9 , caspase-8 , and in a time dependent manner . Positive_regulation FAS CASP3 15192017 1295271 To investigate this possibility , we studied the influence of bovine lactoferrin on Fas mediated apoptosis with regard to expression of [Fas] , *activation* of caspase-8 and , and DNA fragmentation in the colon mucosa of AOM treated rats . Positive_regulation FAS CASP3 15256386 1295941 Be-ferritin induced lung macrophage [CD95] ( Fas ) expression and the *activation* of intracellular , -8 and -9 . Positive_regulation FAS CASP3 15370668 1297377 Also , increased expression of the pro-apoptotic Bcl-2 members Bax , Bad and activation of and caspase 9 , but not the *activation* of caspase 8 or [Fas] were detected in the NS1 transfected cells . Positive_regulation FAS CASP3 16051289 1498685 Meanwhile , immunoblotting analysis also showed that the co-administration of esculetin and Taxol could increase the expression of Bax and the cytosolic release of cytochrome C and *enhance* the expression of [Fas] and Fas ligand while the activation of caspase-8 and was also increased . Positive_regulation FAS CASP3 16514159 1530769 Taken together , these studies show that P. gingivalis can induce epithelial cell apoptosis through [Fas-FasL] up-regulation and *activation* of and caspase-8 . Positive_regulation FAS CASP3 16646028 1557167 [Fas] stimulation activated NF-kappaB and AP-1 , and this response *required* activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation FAS CASP3 16646028 1557300 [Fas] proinflammatory signaling is *dependent* upon activity and FLIP expression . Positive_regulation FAS CASP3 16786109 1577398 It was found that CSE treatment resulted in the upregulation of [Fas/APO-1] receptor and *activation* of . Positive_regulation FAS CASP3 17208988 1732436 Ten days post-MI , apoptosis among granulation tissue cells was significantly suppressed in the olmesartan treated hearts , where expression of [Fas] , Bax , procaspase-3 , and Daxx and *activation* of , c-Jun NH ( 2 ) -terminal kinase , and c-Jun were all significantly attenuated . Positive_regulation FAS CASP3 17454143 1730107 In vitro , pre-treatment with [ 6 ] -gingerol reduced UVB induced intracellular reactive oxygen species levels , *activation* of , -8 , -9 , and [Fas] expression . Positive_regulation FAS CASP3 17692826 1788555 [Anti-Fas] induced *activation* of and PARP cleavage in WT cells but not in TNF receptor deleted cells . Positive_regulation FAS CASP3 18157585 1918894 TIMP-3 treatment induced the expression of [Fas] and Fasl proteins , and the *activation* of caspase-8 and . Positive_regulation FAS CASP3 18209090 1857837 S1P also enhanced [Fas] expression and Fas mediated *induction* in salivary gland epithelial cells . Positive_regulation FAS CASP3 18386902 1907126 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , activation , and [Fas] *induction* . Positive_regulation FAS CASP3 19111607 2031751 However , recent studies have shown that [Fas] can *induce* nonapoptotic when caspase activity is inhibited . Positive_regulation FAS CASP3 19193734 2054142 The expression of Fas and was localized in the same cell types as apoptosis occurred , and expression levels of [Fas] , FasL , and active caspase-3 were significantly *increased* compared with controls . Positive_regulation FAS CASP3 19259823 2072598 Significant enhancement of [Fas] externalization , loss of mitochondrial membrane potential (MMP) , and *activation* of and caspase-8 were observed after the combined treatment . Positive_regulation FAS CASP3 19429345 2077271 Matrine induces apoptosis in gastric carcinoma cells via alteration of [Fas/FasL] and *activation* of . Positive_regulation FAS CASP3 20138036 2213629 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Positive_regulation FAS CASP3 20138036 2213669 Here we describe the fate of Fas downstream of the FasL induced internalization step , including formation of *dependent* SDS-stable [Fas] complexes , which is mediated by cytoskeleton integrity . Positive_regulation FAS CASP3 20471514 2258016 The combined treatment resulted in a stronger activation of caspase 8 and 9 , moderate *activation* of , and increased expression of [Fas] and tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) -DR5 receptors . Positive_regulation FAS CASP3 21418345 2427162 S100A12 exposure induced [Fas] expression and *activation* of in cultured airway smooth muscle cells , suggesting that airway smooth muscle abnormalities observed in S100A12 TG mice may be mediated through myocyte apoptosis . Positive_regulation FAS CASP3 21717192 2538823 The induction of apoptosis appears to occur through the upregulation of [Fas/FasL] and Bax , downregulation of Bcl-2 , and *activation* of , -8 , and -9 , which then trigger major apoptotic cascades . Positive_regulation FAS CASP3 23132899 2696541 We found that STC induces apoptosis in these cells in a dose dependent manner and leads to the activation of [Fas] and caspase-8 , cleavage of Bid , mitochondrial damage , and *activation* of . Positive_regulation FAS CASP3 23530784 2762286 Various methods to inhibit apoptosis including the cell surface [Fas] receptor pathway *inhibitors* , inhibitors , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation FAS CASP3 23816832 2828892 inhibitor also efficiently *blocked* [CD95] ( APO-1/CD95 ) and Bax expression , caspase-3 activation and PARP cleavage , whereas antioxidant N-acetyl-l-cysteine , AMPK inhibitor and AMPK siRNA effectively blocked the AMPK phosphorylation . Positive_regulation FAS CASP3 8840958 386871 Specific tetrapeptide inhibitors of ICE ( Acetyl-Tyr-Val-Ala-Asp-chloromethylketone ) or ( Acetyl-Asp-Glu-Val-Asp-aldehyde ) *prevented* the [anti-Fas] antibody mediated activation of p34cdc2 and inhibited apoptosis . Positive_regulation FAS CASP4 10391681 626701 [Fas] ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation FAS CASP4 10602493 574833 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Positive_regulation FAS CASP4 12605597 1079469 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block [Fas-] and etoposide *induced* activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation FAS CASP4 13677932 1140093 We examined whether a broad-range inhibitor ( C.I. ) can *inhibit* the [Fas] expression enhanced by LD-anticancer drugs . Positive_regulation FAS CASP4 13677932 1140106 However , the [Fas] expression enhanced by LD-ara-C or LD-VP-16 was not *inhibited* by a broad-range inhibitor . Positive_regulation FAS CASP4 16646028 1557168 [Fas] stimulation activated NF-kappaB and AP-1 , and this response *required* activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation FAS CASP4 16646028 1557301 [Fas] proinflammatory signaling is *dependent* upon activity and FLIP expression . Positive_regulation FAS CASP4 18386902 1907127 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , activation , and [Fas] *induction* . Positive_regulation FAS CASP4 19111607 2031752 However , recent studies have shown that [Fas] can *induce* nonapoptotic when caspase activity is inhibited . Positive_regulation FAS CASP4 20138036 2213630 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Positive_regulation FAS CASP4 20138036 2213670 Here we describe the fate of Fas downstream of the FasL induced internalization step , including formation of *dependent* SDS-stable [Fas] complexes , which is mediated by cytoskeleton integrity . Positive_regulation FAS CASP4 23530784 2762287 Various methods to inhibit apoptosis including the cell surface [Fas] receptor pathway *inhibitors* , inhibitors , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation FAS CASP5 10391681 626702 [Fas] ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation FAS CASP5 10602493 574834 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Positive_regulation FAS CASP5 12605597 1079470 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block [Fas-] and etoposide *induced* activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation FAS CASP5 13677932 1140094 We examined whether a broad-range inhibitor ( C.I. ) can *inhibit* the [Fas] expression enhanced by LD-anticancer drugs . Positive_regulation FAS CASP5 13677932 1140107 However , the [Fas] expression enhanced by LD-ara-C or LD-VP-16 was not *inhibited* by a broad-range inhibitor . Positive_regulation FAS CASP5 16646028 1557169 [Fas] stimulation activated NF-kappaB and AP-1 , and this response *required* activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation FAS CASP5 16646028 1557302 [Fas] proinflammatory signaling is *dependent* upon activity and FLIP expression . Positive_regulation FAS CASP5 18386902 1907128 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , activation , and [Fas] *induction* . Positive_regulation FAS CASP5 19111607 2031753 However , recent studies have shown that [Fas] can *induce* nonapoptotic when caspase activity is inhibited . Positive_regulation FAS CASP5 20138036 2213631 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Positive_regulation FAS CASP5 20138036 2213671 Here we describe the fate of Fas downstream of the FasL induced internalization step , including formation of *dependent* SDS-stable [Fas] complexes , which is mediated by cytoskeleton integrity . Positive_regulation FAS CASP5 23530784 2762288 Various methods to inhibit apoptosis including the cell surface [Fas] receptor pathway *inhibitors* , inhibitors , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation FAS CASP6 10391681 626703 [Fas] ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation FAS CASP6 10602493 574835 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Positive_regulation FAS CASP6 12605597 1079471 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block [Fas-] and etoposide *induced* activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation FAS CASP6 13677932 1140095 We examined whether a broad-range inhibitor ( C.I. ) can *inhibit* the [Fas] expression enhanced by LD-anticancer drugs . Positive_regulation FAS CASP6 13677932 1140108 However , the [Fas] expression enhanced by LD-ara-C or LD-VP-16 was not *inhibited* by a broad-range inhibitor . Positive_regulation FAS CASP6 16646028 1557170 [Fas] stimulation activated NF-kappaB and AP-1 , and this response *required* activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation FAS CASP6 16646028 1557303 [Fas] proinflammatory signaling is *dependent* upon activity and FLIP expression . Positive_regulation FAS CASP6 18386902 1907129 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , activation , and [Fas] *induction* . Positive_regulation FAS CASP6 19111607 2031754 However , recent studies have shown that [Fas] can *induce* nonapoptotic when caspase activity is inhibited . Positive_regulation FAS CASP6 20138036 2213632 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Positive_regulation FAS CASP6 20138036 2213672 Here we describe the fate of Fas downstream of the FasL induced internalization step , including formation of *dependent* SDS-stable [Fas] complexes , which is mediated by cytoskeleton integrity . Positive_regulation FAS CASP6 23530784 2762289 Various methods to inhibit apoptosis including the cell surface [Fas] receptor pathway *inhibitors* , inhibitors , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation FAS CASP7 10391681 626704 [Fas] ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation FAS CASP7 10602493 574836 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Positive_regulation FAS CASP7 10616904 575854 [Fas] *activation* of caspase-2 , caspase-3 , , and caspase-8 and the proteolytic cleavage of substrates such as BID , protein kinase Cdelta , and poly ( ADP-ribose ) polymerase were completely defective in the FADD mutant cell lines . Positive_regulation FAS CASP7 12605597 1079472 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block [Fas-] and etoposide *induced* activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation FAS CASP7 13677932 1140096 We examined whether a broad-range inhibitor ( C.I. ) can *inhibit* the [Fas] expression enhanced by LD-anticancer drugs . Positive_regulation FAS CASP7 13677932 1140109 However , the [Fas] expression enhanced by LD-ara-C or LD-VP-16 was not *inhibited* by a broad-range inhibitor . Positive_regulation FAS CASP7 16646028 1557171 [Fas] stimulation activated NF-kappaB and AP-1 , and this response *required* activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation FAS CASP7 16646028 1557304 [Fas] proinflammatory signaling is *dependent* upon activity and FLIP expression . Positive_regulation FAS CASP7 18386902 1907130 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , activation , and [Fas] *induction* . Positive_regulation FAS CASP7 19111607 2031755 However , recent studies have shown that [Fas] can *induce* nonapoptotic when caspase activity is inhibited . Positive_regulation FAS CASP7 20138036 2213633 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Positive_regulation FAS CASP7 20138036 2213673 Here we describe the fate of Fas downstream of the FasL induced internalization step , including formation of *dependent* SDS-stable [Fas] complexes , which is mediated by cytoskeleton integrity . Positive_regulation FAS CASP7 23530784 2762290 Various methods to inhibit apoptosis including the cell surface [Fas] receptor pathway *inhibitors* , inhibitors , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation FAS CASP8 10194469 603889 [CD95] signaling to the mitochondria *required* , whereas cytochrome c release in response to DNA damage was caspase independent . Positive_regulation FAS CASP8 10391681 626705 [Fas] ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation FAS CASP8 10602493 574837 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Positive_regulation FAS CASP8 10713706 676263 We provide evidence that both , radiation and [CD95] stimulation , *induce* the rapid activation of and BID followed by apoptosis in Jurkat T-cells . Positive_regulation FAS CASP8 10845905 700693 IFN-gamma induced Fas expression of the cells without the activation of caspase8 or caspase3 during 16 hours of incubation , while deprivation of EPO induced expression of [Fas] and the *activation* of both and caspase3 . Positive_regulation FAS CASP8 11245678 793223 Increased levels of [Fas] death receptor , Bax , and cytochrome c , *activation* of , and abnormalities in mitochondria in the thalamus significantly precede the activation of caspase 3 and the appearance of neuronal apoptosis at 24 hr . Positive_regulation FAS CASP8 11337381 812183 Thus , the Apert S252W FGFR-2 mutation promotes apoptosis in human osteoblasts through activation of protein kinase C , overexpression of IL-1 and [Fas] , *activation* of , and increased Bax/Bcl-2 levels , leading to increased effector caspases and DNA fragmentation . Positive_regulation FAS CASP8 11352849 814895 Albumin overload also resulted in a dose dependent upregulation of [Fas] and Fas associated protein with death domain ( FADD ) , and *activation* of . Positive_regulation FAS CASP8 11865194 917917 All the [anti-Fas] antibody mediated signals for apoptosis induction in NOS4 cells were completely *blocked* by a inhibitor , Z-IETD-FMK . Positive_regulation FAS CASP8 12605597 1079473 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block [Fas-] and etoposide *induced* activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation FAS CASP8 12880425 1115735 Various molecular events accompanied the cytotoxic effects of CMI/MI. Generation of ROS and hyperpolarization of mitochondrial transmembrane potential ( DeltaPsim ) were early events , followed by increased [Fas] expression and *activation* of , and then activation of caspase-3 and -9 . Positive_regulation FAS CASP8 12959751 1138349 Virally encoded genes inhibit the *activation* of by the TNF receptor and [Fas] ; Positive_regulation FAS CASP8 13677932 1140097 We examined whether a broad-range inhibitor ( C.I. ) can *inhibit* the [Fas] expression enhanced by LD-anticancer drugs . Positive_regulation FAS CASP8 13677932 1140110 However , the [Fas] expression enhanced by LD-ara-C or LD-VP-16 was not *inhibited* by a broad-range inhibitor . Positive_regulation FAS CASP8 14646514 480073 ( FLICE ) can associate with and be *activated* by [CD95] ( APO-1/Fas ) , an apoptosis inducing member of the Tumour Necrosis Factor receptor family . Positive_regulation FAS CASP8 14992818 1215726 Cellular FLICE inhibitory protein-long ( c-FLIP-L ) is an endogenous inhibitor of the *activation* of by [Fas] . Positive_regulation FAS CASP8 15144569 1247581 After HuIFN-beta exposure , COH and CC-M2 cells showed increased levels of [Fas] and FasL proteins , alteration of mitochondrial membrane potential , and *activation* of caspase-9 , , and caspase-3 in a time dependent manner . Positive_regulation FAS CASP8 15161627 1252856 *Activation* of by [Fas] engagement markedly increased the probe 's cleavage , whereas treatment of caspase 8-deficient cells with anti-Fas did not increase cleavage . Positive_regulation FAS CASP8 15192017 1295272 To investigate this possibility , we studied the influence of bovine lactoferrin on Fas mediated apoptosis with regard to expression of [Fas] , *activation* of and caspase-3 , and DNA fragmentation in the colon mucosa of AOM treated rats . Positive_regulation FAS CASP8 15207716 1261660 We report here that disruption of lipid rafts by cholesterol depleting compounds ( methyl-beta-cyclodextrin , filipin III , cholesterol oxidase , and mevastatin ) leads to a spontaneous clustering of Fas in the non-raft compartment of the plasma membrane , formation of [Fas-FADD] complexes , *activation* of , and apoptosis . Positive_regulation FAS CASP8 15289452 1302595 By in vitro transfection , alpha-SN expression was shown to be correlated with glucocorticoid sensitive apoptosis , possibly caused by the enhanced expression of glucocorticoid receptor (GR) , caspase *activations* ( , caspase-9 ) , [CD95] up-regulation , and reactive oxygen species ( ROS ) production . Positive_regulation FAS CASP8 15626723 1380887 Asiatic acid treatment triggered the mitochondrial apoptotic pathway indicated by changing Bax/Bcl-2 ratios , cytochrome c release , and caspase-9 activation , but it did not act on [Fas/Fas] ligand pathways and the *activation* of . Positive_regulation FAS CASP8 16051289 1498686 Meanwhile , immunoblotting analysis also showed that the co-administration of esculetin and Taxol could increase the expression of Bax and the cytosolic release of cytochrome C and *enhance* the expression of [Fas] and Fas ligand while the activation of and caspase-3 was also increased . Positive_regulation FAS CASP8 16154281 1461328 The extrinsic pathway is activated later on ( within six hours of anesthesia exposure ) , as measured by the up-regulation of [Fas] protein and the *activation* of in 7-day-old rats , but remains inactivated in 14-day-old rats . Positive_regulation FAS CASP8 16514159 1530770 Taken together , these studies show that P. gingivalis can induce epithelial cell apoptosis through [Fas-FasL] up-regulation and *activation* of caspase-3 and . Positive_regulation FAS CASP8 16646028 1557172 [Fas] stimulation activated NF-kappaB and AP-1 , and this response *required* activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation FAS CASP8 16646028 1557305 [Fas] proinflammatory signaling is *dependent* upon activity and FLIP expression . Positive_regulation FAS CASP8 17142969 1653804 SZKJT treatment triggered the mitochondrial apoptotic pathway indicated by changing Bax/Bcl-2 ratios , cytochrome c release and caspase-9 activation , but did not act on [Fas/Fas] ligand pathways and the *activation* of . Positive_regulation FAS CASP8 17159907 1678920 Cysteine 199 mutants no longer form SDS-stable aggregates , and inhibition of palmitoylation reduces internalization of [CD95] and *activation* of . Positive_regulation FAS CASP8 17195944 1695481 In addition , we show that isolated spermatocytes expressing high levels of [Fas] display *activation* of , -9 , -3 , -6 and -2 , as well as increased levels of intracellular calcium and decreased pH , which coincides with stabilization of p53 , and transcriptional activation of PUMA and Fas . Positive_regulation FAS CASP8 18025281 1827777 SAHA also activated the extrinsic apoptosis pathway , including increased [Fas] and Fas ligand (FasL) expression , *activation* of , and cleavage of Bid . Positive_regulation FAS CASP8 18058803 1903263 AMR-Me induced DNA fragmentation and PARP degradation which were preceded by changing Bax/Bcl-2 ratios , cytochrome c release , and subsequent induction of pro-caspase-9 and -7 processing in breast carcinoma MCF-7 cells , but it did not act on [Fas/Fas] ligand pathways and the *activation* of , suggesting AMR-Me triggered the mitochondrial apoptotic pathway . Positive_regulation FAS CASP8 18157585 1918895 TIMP-3 treatment induced the expression of [Fas] and Fasl proteins , and the *activation* of and caspase-3 . Positive_regulation FAS CASP8 18373696 1898895 Radiation also induced transcriptional upregulation of [Fas] , *activation* , Bax and Bak activation , and phosphorylation and downregulation of Bcl-2 . Positive_regulation FAS CASP8 18386902 1907131 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , activation , and [Fas] *induction* . Positive_regulation FAS CASP8 18653623 1967110 IGF1 did not affect [Fas] expression or *activation* by anti-Fas of , but inhibited the depolarization of the mitochondrial membrane . Positive_regulation FAS CASP8 19111607 2031756 However , recent studies have shown that [Fas] can *induce* nonapoptotic when caspase activity is inhibited . Positive_regulation FAS CASP8 19259823 2072599 Significant enhancement of [Fas] externalization , loss of mitochondrial membrane potential (MMP) , and *activation* of caspase-3 and were observed after the combined treatment . Positive_regulation FAS CASP8 20138036 2213634 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Positive_regulation FAS CASP8 20138036 2213674 Here we describe the fate of Fas downstream of the FasL induced internalization step , including formation of *dependent* SDS-stable [Fas] complexes , which is mediated by cytoskeleton integrity . Positive_regulation FAS CASP8 21854868 2500969 [Fas/FasL] dependent and -independent *activation* of in doxorubicin treated human breast cancer MCF-7 cells : ADAM10 down-regulation activates Fas/FasL signaling pathway . Positive_regulation FAS CASP8 22108623 2517467 2-Hydroxy-3-methylanthraquinone from Hedyotis diffusa WILLD induces apoptosis via alteration of [Fas/FasL] and *activation* of in human leukemic THP-1 cells . Positive_regulation FAS CASP8 22492309 2624600 Sulfuretin also activated the extrinsic apoptosis pathway , that is , it increased the expressions of [Fas] and FasL , the *activation* of , and the cleavage of Bid . Positive_regulation FAS CASP8 22861189 2719707 NO donor increased [CD95] expression and *activation* of and 3 in HepG2 , Huh7 , and Hep3B cells . Positive_regulation FAS CASP8 23530784 2762291 Various methods to inhibit apoptosis including the cell surface [Fas] receptor pathway *inhibitors* , inhibitors , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation FAS CASP8 9837871 552440 Moreover , E1A induces procaspase-8 processing and cell death in cells deleted of FADD , an adaptor protein critical for [Fas/TNFR1] *activation* of . Positive_regulation FAS CASP9 10391681 626706 [Fas] ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation , activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation FAS CASP9 10602493 574838 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Positive_regulation FAS CASP9 11256888 764250 Spontaneous neutrophil apoptosis does not require [Fas] ligation , but is *mediated* by caspases 3 , 8 and possibly and also involves activation of protein kinase C-delta . Positive_regulation FAS CASP9 12605597 1079474 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block [Fas-] and etoposide *induced* activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and cytochrome c release . Positive_regulation FAS CASP9 12628746 1067158 In vitro , we did mechanistic studies in lymphoid cell lines and found that pro-caspase-8 at the [CD95] death receptor and the mitochondrial *activation* of are the enzyme targets that require sufficient intracellular reduced glutathione for their activation . Positive_regulation FAS CASP9 13677932 1140098 We examined whether a broad-range inhibitor ( C.I. ) can *inhibit* the [Fas] expression enhanced by LD-anticancer drugs . Positive_regulation FAS CASP9 13677932 1140111 However , the [Fas] expression enhanced by LD-ara-C or LD-VP-16 was not *inhibited* by a broad-range inhibitor . Positive_regulation FAS CASP9 15144569 1247582 After HuIFN-beta exposure , COH and CC-M2 cells showed increased levels of [Fas] and FasL proteins , alteration of mitochondrial membrane potential , and *activation* of , caspase-8 , and caspase-3 in a time dependent manner . Positive_regulation FAS CASP9 15370668 1297378 Also , increased expression of the pro-apoptotic Bcl-2 members Bax , Bad and activation of caspase 3 and , but not the *activation* of caspase 8 or [Fas] were detected in the NS1 transfected cells . Positive_regulation FAS CASP9 16646028 1557173 [Fas] stimulation activated NF-kappaB and AP-1 , and this response *required* activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation FAS CASP9 16646028 1557306 [Fas] proinflammatory signaling is *dependent* upon activity and FLIP expression . Positive_regulation FAS CASP9 18234961 1864294 Targeting Mcl-1 in these melanoma cell lines with specific small interfering RNA was sufficient to sensitize them to both [anti-Fas] mAb induced apoptosis and *activation* of . Positive_regulation FAS CASP9 18386902 1907132 Totally , these findings suggest that ergocalciferol causes HL-60 apoptosis via a modulation of mitochondria involving ROS production , GSH depletion , activation , and [Fas] *induction* . Positive_regulation FAS CASP9 19111607 2031757 However , recent studies have shown that [Fas] can *induce* nonapoptotic when caspase activity is inhibited . Positive_regulation FAS CASP9 20138036 2213635 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Positive_regulation FAS CASP9 20138036 2213675 Here we describe the fate of Fas downstream of the FasL induced internalization step , including formation of *dependent* SDS-stable [Fas] complexes , which is mediated by cytoskeleton integrity . Positive_regulation FAS CASP9 23530784 2762292 Various methods to inhibit apoptosis including the cell surface [Fas] receptor pathway *inhibitors* , inhibitors , over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed . Positive_regulation FAS CASR 18455448 1916039 GdCl3 , a specific activator of CaSR , further enhanced expression , along with increases in intracellular calcium and apoptosis in cardiomyocytes during I/R. Activation of CaSR down-regulated Bcl-2 expression , *up-regulated* caspase-3 and [Fas/FasL] expression and stimulated ERK1/2 phosphorylation . Positive_regulation FAS CAST 16547594 1568154 The increases in levels were *followed* by serial increases in the expression levels of NF-kappaB p65 and [Fas] . Positive_regulation FAS CAST 16547594 1568170 Fas ligand (Fas-L) protein levels increased after treatment of the parental T.Tn and calpastatin transfected cells with PEP , suggesting the synergism between *induced* [Fas] and PEP induced Fas-L . Positive_regulation FAS CAT 10425197 632766 When rat hepatocytes were transfected with a construct that linked the region of -9700 and -4606 with the insulin response region located between -265 to +65 , [FAS] promoter activity was *induced* 15-fold . Positive_regulation FAS CAV1 18922892 1977251 Stable expression and knockdown studies of Cav1 in tumor cells showed that phosphorylated expression stimulates Rho activation , *stabilizes* FAK association with [FAs] , and promotes cell migration and invasion in a ROCK dependent and Src dependent manner . Positive_regulation FAS CAV1 19934968 2167471 Simvastatin also decreased cholesterol content in lipid raft fractions , suppressed expression in the lipid rafts , and *induced* [Fas] translocation into lipid rafts , suggesting that simvastatin may inhibit the prosurvival PI3K/Akt pathway and trigger caspase-3 dependent apoptotic cell death through the modulation of lipid rafts . Positive_regulation FAS CAV1 21382479 2416031 We found that *regulated* [Fas] signaling and mediated the communication between extrinsic and intrinsic pathways . Positive_regulation FAS CCL2 11595074 870102 IFN-gamma pretreatment and [Fas] Ag stimulation synergistically *induced* not only apoptosis but also IL-8 and secretion . Positive_regulation FAS CCL2 20179890 2215936 As shown in our preliminary study , MCP-1 induced apoptosis of hUVECs in a dose dependent manner at both 24 h and 48 h. FACS and Western blot analysis results in the present study indicated that *promoted* the expression of proapoptotic proteins Bax and [Fas] and inhibited the expression of antiapoptotic protein Bcl-2 . Positive_regulation FAS CCNG1 12637333 1099234 Similarly , in vivo of NOD-SCID repopulating cells upon transplantation , *resulted* in up-regulation of [Fas] expression . Positive_regulation FAS CCNG1 9389691 467160 IFN-gamma both inhibits cell and *induces* expression of the [Fas-receptor] , resulting in subsequent apoptosis of hematopoietic progenitor cells . Positive_regulation FAS CCR5 12131184 966762 Isolated activation of by membrane bound , or soluble R5 Env *causes* a [Fas-] and caspase-8 dependent death also of uninfected CD4 T cells . Positive_regulation FAS CD28 12855690 1134963 These results served as the basis for structure/function analysis of the CD95L promoter to elucidate the mechanism for *mediated* enhancement of [CD95L] . Positive_regulation FAS CD36 15841205 1398158 *mediates* the transfer of [fatty acids (FAs)] across the plasma membranes of muscle and adipose cells , thus playing an important role in regulating peripheral FA metabolism in vivo . Positive_regulation FAS CD3D 11801659 902586 Furthermore , we demonstrate that PRIDDs play an important role in mediated [CD95L] *induction* . Positive_regulation FAS CD3D 11801659 902589 Most interestingly , viral IRFs of human herpes virus 8 ( HHV8 ) totally abolish IRF-1 mediated and strongly reduce mediated [CD95L] *induction* . Positive_regulation FAS CD3D 12618758 1065871 Here we report that an AP-1 site located in the 5 ' untranslated region of the CD95L gene is required for *mediated* induction of the human [CD95L] promoter . Positive_regulation FAS CD3E 11801659 902587 Furthermore , we demonstrate that PRIDDs play an important role in mediated [CD95L] *induction* . Positive_regulation FAS CD3E 11801659 902590 Most interestingly , viral IRFs of human herpes virus 8 ( HHV8 ) totally abolish IRF-1 mediated and strongly reduce mediated [CD95L] *induction* . Positive_regulation FAS CD3E 12618758 1065872 Here we report that an AP-1 site located in the 5 ' untranslated region of the CD95L gene is required for mediated *induction* of the human [CD95L] promoter . Positive_regulation FAS CD3G 11801659 902588 Furthermore , we demonstrate that PRIDDs play an important role in mediated [CD95L] *induction* . Positive_regulation FAS CD3G 11801659 902591 Most interestingly , viral IRFs of human herpes virus 8 ( HHV8 ) totally abolish IRF-1 mediated and strongly reduce mediated [CD95L] *induction* . Positive_regulation FAS CD3G 12618758 1065873 Here we report that an AP-1 site located in the 5 ' untranslated region of the CD95L gene is required for *mediated* induction of the human [CD95L] promoter . Positive_regulation FAS CD4 10601365 574603 Recent studies have demonstrated that engagement of TCR and [Fas] *induces* naive ( + ) T cells to undergo apoptosis , and the same treatment enhances the proliferation of memory CD4 ( + ) T cells . Positive_regulation FAS CD4 12921948 1131033 Expression of [CD95] ( Apo-1/Fas ) and CD45RO on monocytes increased significantly on the 5th day , and expression on monocytes *increased* significantly on the 14th day . Positive_regulation FAS CD4 15153474 1250060 However , in the context of an extensive tumor burden , chronic stimulation of such ( + ) T cells often *leads* to the up-regulation of both [Fas] and Fas ligand , and coexpression of these molecules can potentially result in activation induced cell death and the subsequent loss of effector activity . Positive_regulation FAS CD4 21469125 2422744 We found that ( + ) T lymphocytes *require* [Fas] expression in the recipients ' target cells to induce diabetes . Positive_regulation FAS CD4 7522637 272102 Cross linking of molecules *upregulates* [Fas] antigen expression in lymphocytes by inducing interferon-gamma and tumor necrosis factor-alpha secretion . Positive_regulation FAS CD4 7522637 272103 We show here that cross linking of molecules , induced either by anti-CD4 monoclonal antibody ( MoAb ) Leu3a or by human immunodeficiency virus-1 ( HIV-1 ) envelope protein gp160 , *upregulates* [Fas] Ag expression as well as Fas mRNA in normal lymphocytes . Positive_regulation FAS CD4 7522637 272108 Both INF-gamma and TNF-alpha were found to contribute to Fas Ag upregulation and both anti-IFN-gamma and anti-TNF-alpha antibodies blocked *induced* [Fas] Ag upregulation and lymphocyte apoptosis . Positive_regulation FAS CD4 7522637 272109 These findings strongly suggest that aberrant cytokine secretion *induced* by and consequent upregulation of [Fas] Ag expression might play a critical role in triggering peripheral T-cell apoptosis and thereby contribute to HIV disease pathogenesis . Positive_regulation FAS CD4 7572384 328895 Both these cytokins contributed to Fas Ag up-regulation and antibodies to TNF-alpha and INF-tau abrogated *induced* [Fas] up-regulation and T-cell apoptosis . Positive_regulation FAS CD4 8855300 388203 [Fas] ( CD95 ) expression and death mediating function are *induced* by cross linking on CD4+ T cells . Positive_regulation FAS CD4 8855300 388206 We have found that cross linking *results* in a small but rapid increase in levels of cell surface [Fas] , a member of the tumor necrosis factor receptor family implicated in apoptotic death and maintenance of immune homeostasis . Positive_regulation FAS CD4 9036997 415248 in purified CD4+ T cells , however , *upregulates* [Fas] but not FasL expression . Positive_regulation FAS CD4 9743345 532400 Donor T cell activation in the absence of CD8+ T cell activation *results* in an autoantibody mediated response , no significant [Fas/FasL] up-regulation , impaired elimination of autoreactive B cells , and persistent humoral autoimmunity . Positive_regulation FAS CD40 10223618 561287 stimulation *enhanced* [Fas] expression on HTC/C3 cells . Positive_regulation FAS CD40 12560754 1053741 ligation *had* no effect on cell viability or surface expression of CD54 , CD80 , CD86 or [CD95] . Positive_regulation FAS CD40 12604404 1062637 triggering , however , rescues CLL B-cells from their anergic state and *upregulates* the [FAS] receptor . Positive_regulation FAS CD40 16897814 1607890 signaling *increases* [CD95] expression , sensitizing cells to apoptosis , but sustained CD40 signals rescue B cells from CD95 killing . Positive_regulation FAS CD40 17376892 1760262 However , even though ligation *results* in up-regulation of [CD95] , ALL blasts , unlike normal B cells , remain resistant to apoptosis . Positive_regulation FAS CD40 18469093 1938951 engagement of Th40 cells *induces* [Fas] expression but further confers resistance to Fas mediated cell death in NOD mice . Positive_regulation FAS CD40 21367977 2420687 activation in primary as wells as in KG-1 cells *resulted* in [Fas] up-regulation , providing a mechanism for the CD40 mediated apoptosis . Positive_regulation FAS CD40 7595225 330471 ligation *induces* [Apo-1/Fas] expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway . Positive_regulation FAS CD40 8671668 375155 Furthermore we showed that stimulation of B cells with *induced* the expression of [Fas] molecules on the B cells ( approximately 30 % ) and rendered them highly sensitive to anti-Fas mediated apoptotic cell death . Positive_regulation FAS CD40 8695856 375293 Recent studies using nontransformed B cells and the Ramos Burkitt 's lymphoma ( BL ) B-cell line cells show that ligation at the B-cell surface by activated , CD40 ligand (CD40L) bearing , CD4+ T cells *upregulates* [Fas] expression on B cells and primes B cells for Fas mediated death signals . Positive_regulation FAS CD40 8695856 375294 All 6 of the BL cell line B cells upregulate [Fas] in *response* to ligation , and in 4 of the cases they become sensitive to Fas mediated death signals . Positive_regulation FAS CD40 8902579 393863 In the course of cognate interaction between CD40 ligand (CD40L) bearing CD4+ T cells and CD40 expressing germinal center B cells , ligation *results* in augmented [Fas] expression at the B cell surface . Positive_regulation FAS CD40 9129161 406567 Recent studies have found that [Fas] expression on mouse B cells could be strongly *induced* by ligation , a helper T cell derived signal . Positive_regulation FAS CD40 9464838 475909 In addition , following *up-regulation* of the [Fas] ( CD95 ) surface receptor by ligation , these cells also become susceptible to apoptosis induction by Fas ligation . Positive_regulation FAS CD40 9500787 490957 Engagement of *led* to enhanced [Fas] expression and acquisition of sensitivity to Fas mediated apoptosis in tolerant B cells , similar to that observed in nontolerant , receptor transgenic B cells . Positive_regulation FAS CD40 9531598 496919 Concerning malignant B cells , ligation in the presence of IL-4 strongly *increased* [CD95] expression , but did not markedly increase CD95 induced apoptosis . Positive_regulation FAS CD40 9683298 521427 Activation of neoplastic B cells by ligation *resulted* in significant increases in [Fas] expression and Fas induced apoptosis among the five B-NHL cases tested . Positive_regulation FAS CD40 9759836 536510 In addition , SB203580 selectively reduced CD40 induced CD54/ICAM-1 expression , whereas *dependent* expression of CD40 and [CD95/Fas] and four newly defined CD40-responsive genes cIAP2 , TRAF1 , TRAF4/CART and DR3 were unaffected . Positive_regulation FAS CD40LG 10520003 652571 *stimulated* increases in the surface expression of CD40 , CD54 , CD69 , CD70 , CD80 and [CD95] , whereas Bryostatin induced expression of CD40 , CD54 , CD69 and CD95 but not the co-stimulatory molecules CD70 and CD80 . Positive_regulation FAS CD40LG 8566089 349449 Treatment with anti-IgM and interleukin-4 (IL-4) alone did not induce significant Fas expression but enhanced *mediated* up-regulation of [Fas] expression . Positive_regulation FAS CD40LG 8871610 389538 It has been shown that can *induce* both [Fas] expression and susceptibility to Fas mediated killing in B cells , while anti-Ig can partially rescue B cells from Fas mediated killing . Positive_regulation FAS CD40LG 9045916 416661 In contrast to B-2 cells , B-1 cells expressed [Fas] at only low levels in *response* to alone or CD40L-CD8alpha + interleukin-4 , and were resistant to Fas mediated apoptosis following these treatments . Positive_regulation FAS CD40LG 9045916 416669 While [Fas] expression could be *induced* in B-1 cells to a comparable level as that in B-2 cells by cross linking with an anti-CD8alpha antibody , the sensitivity to Fas mediated apoptosis in B-1 cells was significantly reduced compared with B2 cells . Positive_regulation FAS CD40LG 9221764 442624 Studies with human B cells show that the binding of ( gp39 , CD40L ) to CD40 recruits TNF receptor- associated factor 2 ( TRAF2 ) and TRAF3 to the receptor complex , induces the downregulation of the nonreceptor associated TRAFs in the cell and *induces* an increased expression of [Fas] on the cell surface . Positive_regulation FAS CD44 11466334 839836 In this study , we propose a novel function for CD44 using synovial cells from rheumatoid arthritis ( RA ) patients and demonstrated that CD44 cross linking augmented Fas expression and subsequent Fas mediated apoptosis of the cells : 1 ) cross linking of on RA synovial cells markedly *augmented* [Fas] expression and its mRNA transcription ; Positive_regulation FAS CD44 11466334 839837 2 ) engagement of *up-regulated* [Fas] on the cells within 3 h , much more than IL-1beta and TNF-alpha did ; Positive_regulation FAS CD44 11466334 839838 Based on these findings , we postulate a new concept : that interaction of on RA synovial cells with hyaluronan fragments present in the surrounding extracellular matrix *augments* [Fas] expression as well as Fas mediated apoptosis of synovial cells . Positive_regulation FAS CD44 17136494 1678010 Furthermore , AICD induced by CD3 restimulation was inhibited by hyaluronidase as well as by soluble [Fas] , indicating an interaction between membrane bound hyaluronan and the cell surface was *involved* in the up-regulation of FasL expression on T cells and subsequent AICD . Positive_regulation FAS CD59 23835643 2816034 Reduced expression *led* to increased expression of caspase-3 and [Fas] and decreased expression of Bcl-2 . Positive_regulation FAS CD74 15748897 1379418 In addition , we showed that under non-stress conditions *upregulates* [Fas] expression and activates caspase 8 . Positive_regulation FAS CD74 19968579 2185047 This review describes CD74 protein biology with the emphasis on the *role* of in tumor survival and its new role in regulation of the [Fas] death receptor . Positive_regulation FAS CD79A 23519466 2777240 We found previously that expression of the CML related oncoprotein in myeloid progenitor cells *increases* expression of [Fas associated phosphatase 1 (Fap1)] . Positive_regulation FAS CD79B 23519466 2777241 We found previously that expression of the CML related oncoprotein in myeloid progenitor cells *increases* expression of [Fas associated phosphatase 1 (Fap1)] . Positive_regulation FAS CD80 12944991 1133870 We found that adenovirus mediated rat [B7-1/Fas] gene transfer *induced* ( i ) expression of rat chimeric molecules in osteosarcoma cells , ( ii ) activation of murine T cells , ( iii ) apoptosis of murine osteosarcoma cells in the presence of anti-rat B7-1 mAb in vitro , and ( iv ) therapeutic effects more prominently than B7-1 gene transfer on the development of pulmonary metastasis and survival of mice . Positive_regulation FAS CD8A 11067907 747071 In this study we show that maximal Ag-dependent accumulation of transferred TCR-transgenic ( + ) T cells *requires* [Fas] ( CD95/APO-1 ) expression by the adoptive hosts . Positive_regulation FAS CD8A 9045916 416662 In contrast to B-2 cells , B-1 cells expressed [Fas] at only low levels in *response* to CD40L-CD8alpha alone or + interleukin-4 , and were resistant to Fas mediated apoptosis following these treatments . Positive_regulation FAS CD8A 9045916 416670 While [Fas] expression could be *induced* in B-1 cells to a comparable level as that in B-2 cells by cross linking with an anti-CD8alpha antibody , the sensitivity to Fas mediated apoptosis in B-1 cells was significantly reduced compared with B2 cells . Positive_regulation FAS CD8A 9743345 532380 Differential expression of [Fas] and Fas ligand in acute and chronic graft-versus-host disease : up-regulation of Fas and Fas ligand *requires* T cell activation and IFN-gamma production . Positive_regulation FAS CD8A 9743345 532392 Thus , in this in vivo model of alloantigen immune responsiveness , [Fas/FasL] up-regulation is critically *dependent* on Ag-specific ( donor ) T cell activation and IFN-gamma production . Positive_regulation FAS CD8B 11067907 747072 In this study we show that maximal Ag-dependent accumulation of transferred TCR-transgenic ( + ) T cells *requires* [Fas] ( CD95/APO-1 ) expression by the adoptive hosts . Positive_regulation FAS CD8B 9045916 416663 In contrast to B-2 cells , B-1 cells expressed [Fas] at only low levels in *response* to alone or CD40L-CD8alpha + interleukin-4 , and were resistant to Fas mediated apoptosis following these treatments . Positive_regulation FAS CD8B 9045916 416671 While [Fas] expression could be *induced* in B-1 cells to a comparable level as that in B-2 cells by cross linking with an anti-CD8alpha antibody , the sensitivity to Fas mediated apoptosis in B-1 cells was significantly reduced compared with B2 cells . Positive_regulation FAS CD8B 9743345 532381 Differential expression of [Fas] and Fas ligand in acute and chronic graft-versus-host disease : up-regulation of Fas and Fas ligand *requires* T cell activation and IFN-gamma production . Positive_regulation FAS CD8B 9743345 532393 Thus , in this in vivo model of alloantigen immune responsiveness , [Fas/FasL] up-regulation is critically *dependent* on Ag-specific ( donor ) T cell activation and IFN-gamma production . Positive_regulation FAS CDA 22084681 2362540 For MEC2 cells , *up-regulated* CD11a , CD20 , CD43 , CD45 , CD52 , CD54 , CD62L , CD80 , CD86 , and [CD95] , but FdA had no effect . Positive_regulation FAS CDC73 12709415 1093345 The activated increased the mucosal IL-6 and PECAM-1 , *enhanced* the expression of FasL but not [Fas] , and led to the cleavage of Bid and the release of cytochrome c from mitochondria to activate caspase-9 . Positive_regulation FAS CDH1 24882208 2945897 Loss of the epithelial cell adhesion protein E-cadherin recapitulated this outcome , whereas homotypic engagement *promoted* apoptotic signaling via DR4/DR5 , but not [Fas] . Positive_regulation FAS CDKN1A 10754295 682533 [CD95/Fas] signaling in T lymphocytes *induces* the cell cycle control protein , which promotes apoptosis . Positive_regulation FAS CDKN1A 18614532 1954169 Overexpression of suppressed MDM2 , elevated p53 levels , and *enhanced* [CD95] , BAX , NOXA , and PUMA expression ; Positive_regulation FAS CEBPA 12525499 1064115 Both C/EBPalpha and peroxisome proliferator activated receptor gamma reconstituted [FAS] mRNA expression , but only *restored* insulin sensitivity in the absence of IRS-1 . Positive_regulation FAS CEBPZ 11530940 853808 The FIRE3 mediated sterol response of the [FAS] promoter *requires* as a coactivator . Positive_regulation FAS CFLAR 12432255 1015517 These data suggest that may play a critical role in regulating Fas mediated apoptosis in prostate cancer cells and that modulation of c-FLIP may *enhance* [Fas] signaling based therapies . Positive_regulation FAS CFLAR 18790746 1963553 Mitogen activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of levels and *activation* of [CD95] . Positive_regulation FAS CFLAR 19483104 2107940 In SW480 cells , sorafenib + vorinostat increased [CD95] plasma membrane levels and promoted death inducing signal complex (DISC) formation , and drug toxicity was *blocked* by knockdown of CD95 or overexpression of ( c-FLIP-s ) . Positive_regulation FAS CFTR 12878584 1115640 Thus , WT expression *promotes* a rapid expression of [CD95/CD95] ligand and apoptotic response to P. aeruginosa infection . Positive_regulation FAS CFTR 22314624 2681250 This study found that deficiency in mice *results* in the upregulation and activation of [CD95] . Positive_regulation FAS CGN 20937806 2353624 In contrast , the apoptotic effects of TNF-a , including activation of caspase-8 and PARP-1 ( poly(ADP-ribose) polymerase 1 ) fragmentation , were markedly reduced in the *presence* of , and CGN caused reduced expression of [Fas] . Positive_regulation FAS CIDEA 22278400 2617440 Importantly , we observed that expression in hepatocytes was specifically *induced* by saturated [fatty acids (FAs)] , and such induction was reduced when sterol response element binding protein ( SREBP)1c was knocked down . Positive_regulation FAS CISH 20143175 2220114 Of all tested unsaturated [FAs] , only elaidic acid ( 3-fold ) , ( 3-fold ) and trans10,cis12-CLA ( 13-fold ) *increased* NF-kappaB transactivation in myotubes . Positive_regulation FAS CNR1 20590568 2285778 receptors appear to *exert* a modest tonic activation of [Fas/FADD] complexes in brain . Positive_regulation FAS CRK 12214088 779773 H2O2-treatment resulted in dose dependent increases in cell death due to genomic and mitochondrial DNA damage associated with increased levels of 8-OHdG and the p53 and [CD95] pro-apoptosis genes , reduced levels of the Bcl-2 survival gene , *activation* of JNK and stress kinases , and inhibition of PI3 kinase survival signaling . Positive_regulation FAS CSF1 8870694 389446 Macrophage colony stimulating factor ( ) , which is present at increased levels in MRL/lpr mice , but not in MRL/Mp- +/+ ( MRL/+ ) mice , *induced* the expression of Mac-2 antigen and [Fas] antigen on spleen adherent cells of MRL/+ mice . Positive_regulation FAS CSF2 11601212 581184 After cocultured with rhG-CSF ( 10 ng/ml ) for 96 hours , the apoptosis percentage of Fas transferred HL-60 cells was significantly higher than that of HL-60 cells , and the [Fas] expressions could be *up-regulated* by . Positive_regulation FAS CSF2 8822920 384850 Tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) further increased the [CD95] expression *induced* by . Positive_regulation FAS CSF2 8870694 389447 Macrophage ( M-CSF ) , which is present at increased levels in MRL/lpr mice , but not in MRL/Mp- +/+ ( MRL/+ ) mice , *induced* the expression of Mac-2 antigen and [Fas] antigen on spleen adherent cells of MRL/+ mice . Positive_regulation FAS CSF2 9694505 523716 Hematopoietic cytokines ( stem cell factor , interleukin-3 , granulocyte macrophage [ GM-CSF ] , and granulocyte-colony stimulating factor [ G-CSF ] *contribute* to upregulation of [CD95] on bone marrow cells . Positive_regulation FAS CSF3 9694505 523717 Hematopoietic cytokines ( stem cell factor , interleukin-3 , granulocyte macrophage colony stimulating factor [ GM-CSF ] , and [ G-CSF ] *contribute* to upregulation of [CD95] on bone marrow cells . Positive_regulation FAS CTD 21271215 2392779 *stimulated* the protein levels of [Fas/CD95] , the caspase-3 active form , cytochrome c and Bax , but suppressed the protein levels of pro-caspase-8 , pro-caspase-9 and Bcl-2 , determined by Western blot analysis . Positive_regulation FAS CTR9 12709415 1093346 The activated increased the mucosal IL-6 and PECAM-1 , *enhanced* the expression of FasL but not [Fas] , and led to the cleavage of Bid and the release of cytochrome c from mitochondria to activate caspase-9 . Positive_regulation FAS CTS1 11479223 842144 Although strongly *enhances* [CD95] expression at the cell surface , endogenous CD95/CD95 ligand interactions do not mediate CTS1 induced cell death . Positive_regulation FAS CTSC 16547231 1537672 The apoptotic signaling pathway bypassed [Fas] and TNFRs , and *required* the activity of , a protease which performs the proteolytic maturation of granzyme (Gr) A and GrB proenzymes within the cytolytic granules . Positive_regulation FAS CTSS 17950288 1820029 Cysteine are not *involved* in [Fas/CD95] signalling in primary skin fibroblasts . Positive_regulation FAS CXCL12 11122082 758498 We also demonstrated that the inhibitory effect of on glycophorin A+ erythroid cell development was *mediated* by the functional upregulation of [CD95L] in erythroid cultures . Positive_regulation FAS CYCS 11521188 852424 [CD95 ligand (CD95L)] *induced* mitochondrial release and processing of caspases 3 , 7 , 8 and 9 in LN-18 cells in the absence of an inhibitor of protein synthesis , cycloheximide ( CHX ) . Positive_regulation FAS CYCS 12605597 1079476 Indeed , using Jurkat cells as a model system , we demonstrate that NO donors block [Fas-] and etoposide *induced* caspase activation and apoptosis ( downstream of mitochondrial membrane depolarization ) and release . Positive_regulation FAS CYCS 12949627 1137106 The results suggest that TBF induced apoptosis of HL-60 cells may be *stimulated* by the release of to the cytosol , upregulation of [Fas] expression on the cell surface , and through a caspase-3 dependent mechanism . Positive_regulation FAS CYCS 18485587 1939115 Furthermore , 2'-nitroflavone decreased the expression of the anti-apoptotic Bcl-XL protein , *induced* the release of to cytosol and increased the levels of [Fas] and Fas-L . Positive_regulation FAS CYCS 23207769 2705375 Apoptosis was associated with loss of mitochondrial membrane potential , enhancement of mitochondrial and apoptosis inducing factor ( AIF ) release , elevation of the Bax/Bcl-2 ratio , *activation* of caspase-9 , -3 but not caspase-8 and [Fas/FasL] , and degradation of poly ( ADP-ribose ) polymerase ( PARP ) . Positive_regulation FAS CYP3A4 14615069 1163719 These results show that the [Fas] receptor *mediated* signaling pathways modulate expression in human colon cancer cells . Positive_regulation FAS DAXX 11193028 761658 [Fas] also activates a caspase independent pathway which correlates with Fas induced translocation of Daxx from the nucleus to the cytoplasm and *involves* the interaction of with Fas and Ask1 . Positive_regulation FAS DAXX 14517282 1147339 In this study , we investigated the *role* of in [Fas-] and stress induced apoptosis by small interfering RNA mediated Daxx silencing in mammalian cells . Positive_regulation FAS DAXX 9743501 532548 [Fas] activation *induced* to interact with ASK1 , which consequently relieved an inhibitory intramolecular interaction between the amino- and carboxyl-termini of ASK1 , activating its kinase activity . Positive_regulation FAS DES 12477725 1056080 Testosterone supplementation is able to prevent *induced* [Fas-FasL] up-regulation and apoptosis in the spermatogenic cells . Positive_regulation FAS DISC1 21975294 2492866 We found that [CD95] *induced* caspase-8 activity is important for the initiation of ERK1/2 and p38 MAPK activation . Positive_regulation FAS DISC1 21975294 2492896 Furthermore , we built a mathematical model describing [CD95] mediated MAPK *activation* and apoptosis . Positive_regulation FAS DISC2 21975294 2492867 We found that [CD95] *induced* caspase-8 activity is important for the initiation of ERK1/2 and p38 MAPK activation . Positive_regulation FAS DISC2 21975294 2492897 Furthermore , we built a mathematical model describing [CD95] mediated MAPK *activation* and apoptosis . Positive_regulation FAS DNTT 15066449 1231671 The percentage of *mediated* dUDP nick-end labeling- ( TUNEL- ) , [Fas-] , and annexin-V positive sperm and the proportion of green fluorescing sperm in the acridine orange stain was determined and correlated with sperm concentration , motility , fertilization , and pregnancy . Positive_regulation FAS EGF 10509790 650975 Flowcytometric analyses demonstrated that did not *induce* [Fas] expression on the cell surface while expressions of the EGF receptor were down-regulated . Positive_regulation FAS EGF 10924745 718408 Flow cytometric analyses demonstrated that TGF-beta1 , IL-1beta , and did not *induce* [Fas] expression on the cell surface . Positive_regulation FAS EGF 12586732 1072107 Stimulation of EGFR by *induced* EGFR phosphorylation but no association with [CD95] or CD95 phosphorylation . Positive_regulation FAS EGF 12931129 1157792 [FAS] is overexpressed in the malignant human breast carcinoma MCF-7 cells and its expression is further *enhanced* by the . Positive_regulation FAS EGF 12931129 1157793 The *induced* expression of [FAS] was inhibited by green and black tea extracts . Positive_regulation FAS EGF 17182072 1695209 TNQ was found to suppress the *induced* expression of FAS mRNA and [FAS] protein in MDA-MB-231 cells . Positive_regulation FAS EGF 17182072 1695216 Treatment of MDA-MB-231 cells with PI 3-kinase inhibitors , LY294002 and Wortmannin , inhibited the *induced* expression of [FAS] and nuclear translocation of SREBP-1 . Positive_regulation FAS EGF 17182072 1695219 Furthermore , treatment with kinase inhibitors of EGFR and ErbB-2 suggested that EGFR/ErbB-2 activation was involved in *induced* [FAS] expression . Positive_regulation FAS EGFR 12586732 1072102 Inhibition of tyrosine kinase activity *prevented* [CD95] tyrosine phosphorylation and DISC formation but not hyperosmolarity induced EGFR phosphorylation and EGFR association with CD95 . Positive_regulation FAS EGFR 12586732 1072108 Stimulation of by EGF *induced* EGFR phosphorylation but no association with [CD95] or CD95 phosphorylation . Positive_regulation FAS EGFR 14679192 1211245 *dependent* [CD95-tyrosine] phosphorylation was recently identified as an early step in apoptosis induction via the CD95 system ( Reinehr , R. , Schliess , F. , and Häussinger , D. ( 2003 ) FASEB J. 17 , 731-733 ) . Positive_regulation FAS EGFR 15660394 1375907 Inhibition of tyrosine kinase activity by AG1478 and cyclic adenosine monophosphate had no effect on hyperosmotic CD95-EGFR association in the cytosol but *prevented* [CD95] tyrosine phosphorylation , targeting of the protein complex to the plasma membrane , and formation of the death inducing signaling complex (DISC) . Positive_regulation FAS EGFR 15917250 1433515 Activated then *triggered* an AG1478-sensitive [CD95-tyrosine] phosphorylation , which was a signal for membrane targeting of the EGFR/CD95 complex , subsequent recruitment of Fas associated death domain and caspase 8 , and apoptosis induction . Positive_regulation FAS EGFR 17182072 1695220 Furthermore , treatment with kinase inhibitors of EGFR and ErbB-2 suggested that activation was *involved* in EGF induced [FAS] expression . Positive_regulation FAS EGFR 17182072 1695224 The PI 3-kinase inhibitors and tyrosine kinase inhibitors of and ErbB-2 also *reduced* constitutive [FAS] expression . Positive_regulation FAS EGFR 22182753 2543320 Then the *role* of in activating [CD95] death receptor in liver parenchymal cells ( PC ) and hepatic stellate cells (HSC) , which represent a liver stem/progenitor cell compartment , is described summarizing different ways of CD95- and EGFR dependent signaling in the liver . Positive_regulation FAS EIF2AK2 10191197 603506 Expression of an inactive form of ( K296R ) or the vector alone did not *induce* apoptosis or elevate [Fas] mRNA levels . Positive_regulation FAS EIF2AK2 10951573 723699 Significantly , despite the *mediated* upregulation of [Fas] mRNA expression , the Fas receptor-ligand pathway is not needed for PKR induced apoptosis . Positive_regulation FAS EIF4G1 9821956 548682 In this study , we show that activation of the [Fas/CD95] receptor complex in Jurkat cells *induces* the degradation of , the inhibition of total protein synthesis and cell death . Positive_regulation FAS EIF4G2 9821956 548683 In this study , we show that activation of the [Fas/CD95] receptor complex in Jurkat cells *induces* the degradation of , the inhibition of total protein synthesis and cell death . Positive_regulation FAS EIF4G3 9821956 548684 In this study , we show that activation of the [Fas/CD95] receptor complex in Jurkat cells *induces* the degradation of , the inhibition of total protein synthesis and cell death . Positive_regulation FAS EPHB2 12207331 983601 Further analysis with A3.01 T cells revealed that the proinflammatory signaling activity of [CD95] was *mediated* by , p38 and NF-kappaB signaling pathways . Positive_regulation FAS EPHB2 15454340 1301162 activation by PMA did not *induce* death or [Fas] upregulation , suggesting that Fas may be important for the induction of apoptosis and the existence of an additional factor activated by Dex which enables the cooperation between the Dex activated ERK and Fas pathways , during apoptosis of osteocytes . Positive_regulation FAS EPHB2 16538383 1555315 Accordingly , prolonged stimulation *activated* caspase 8 and strongly potentiated [Fas] signaling . Positive_regulation FAS ERBB2 12517789 1039300 Here , we demonstrate that mediated *induction* of [FAS] is inhibitable by Herceptin and tyrosine kinase inhibitors of HER2 . Positive_regulation FAS ERBB2 15172638 1253960 Taken together , the results presented here suggest that *regulates* [FAS] expression in HNSCC and point out Ki-67 as a useful prognostic marker for these tumors . Positive_regulation FAS ERBB2 15780499 1385303 Her-2/neu overexpression stimulates the FAS promoter and ultimately mediates increased endogenous fatty synthesis , and this *mediated* induction of breast cancer associated [FAS] is inhibitable by trastuzumab . Positive_regulation FAS ERBB2 16247515 1471649 Second , Her-2/neu overexpression stimulates the activity of FAS gene promoter and ultimately mediates increased endogenous fatty acid biosynthesis , while this *induced* upregulation of breast cancer associated [FAS] is inhibitable by anti-Her-2/neu antibodies such as trastuzumab ( Herceptin ( TM ) ) . Positive_regulation FAS ERBB2 17182072 1695221 Furthermore , treatment with kinase inhibitors of EGFR and ErbB-2 suggested that activation was *involved* in EGF induced [FAS] expression . Positive_regulation FAS ERBB2 17182072 1695225 The PI 3-kinase inhibitors and tyrosine kinase inhibitors of EGFR and also *reduced* constitutive [FAS] expression . Positive_regulation FAS ERBB2 17539658 1762289 Taken together , these findings extend our previous study to indicate that EGCG may be useful in the chemoprevention of breast carcinoma in which [FAS] overexpression *results* from or/and HER3 signaling . Positive_regulation FAS ERBB3 17539658 1762290 Taken together , these findings extend our previous study to indicate that EGCG may be useful in the chemoprevention of breast carcinoma in which [FAS] overexpression *results* from HER2 or/and signaling . Positive_regulation FAS EZR 18941185 1978103 Ezrin and moesin have to be present together for the formation of Fas aggregates since down-regulation of either or moesin expression with small interfering RNAs completely *inhibits* [Fas] aggregate formation . Positive_regulation FAS FADD 10072523 594488 These results suggest that alone is *sufficient* for initiation of [Fas] signaling in primary T cells , but other pathways may operate in B cells . Positive_regulation FAS FADD 14668343 1210916 Previous studies in Jurkat cells have demonstrated that the is *required* for [Fas] mediated signaling to apoptosis and necrosis . Positive_regulation FAS FADD 15017386 1257097 Interestingly , mitogenic stimulation , but not [Fas] ligation , *induced* a unique post-translational modification of . Positive_regulation FAS FADD 23606538 2778754 [Fas] signaling strongly *induced* the phosphorylation of at Ser ( 194 ) and Pin1 at Ser ( 16 ) , as well as their nuclear accumulation . Positive_regulation FAS FAIM3 19414556 2075448 These proteins also inhibit inflammatory cell apoptosis/cell death while inhibiting [Fas] expression , activating protein kinase B/AKT , and *inducing* . Positive_regulation FAS FAS 10464273 640373 Susceptibility to Fas induced death correlated with an *increase* in expression of a tunicamycin-inhibitable high molecular weight form of [Fas] but not with aggregate expression of . Positive_regulation FAS FAS 10480436 643504 [Fas] ( CD95 , APO-1 ) is a member of the TNF receptor family , and engagement of by its ligand , Fas ligand (FasL) , can *induce* apoptotic death of Fas expressing cells . Positive_regulation FAS FAS 10811232 693016 Like pancreatic beta cells , betaTC-3 cells do not constitutively express [Fas] , but expression can be *induced* with IL-1 and IFN-gamma . Positive_regulation FAS FAS 11404388 825440 There was a strong correlation between *stimulated* apoptosis and creatinine clearance as well as [Fas] expression . Positive_regulation FAS FAS 11713312 881096 FAS2-lacZ fusion constructs deleted for this region showed high reporter gene expression even in the absence of FAS1 , arguing for a negatively acting downstream repression site ( DRS ) responsible for *dependent* expression of [FAS2] . Positive_regulation FAS FAS 11713312 881098 Our data suggest that the gene product , in addition to its catalytic function , is also *required* for the coordinate biosynthetic control of the yeast [FAS] complex . Positive_regulation FAS FAS 11911840 924254 A significant up-regulation of [Fas/CD95] expression was *detected* after exposure to topotecan and CPT83 , whereas cisplatin induced a low increase and taxol did not modify expression . Positive_regulation FAS FAS 12031707 947716 Hypoxia predisposes neonatal rat ventricular myocytes to apoptosis induced by *activation* of the [Fas] ( CD95/Apo-1 ) receptor : activation and apoptosis in hypoxic myocytes . Positive_regulation FAS FAS 12556501 1051752 Two adjacent trimeric ligands are *required* for [Fas] signaling and formation of a death inducing signaling complex . Positive_regulation FAS FAS 16246840 1489627 Nitric oxide negatively regulates [Fas] *induced* apoptosis through inhibition of ubiquitin-proteasome mediated degradation of FLICE inhibitory protein . Positive_regulation FAS FAS 19193734 2054141 The expression of and active caspase-3 was localized in the same cell types as apoptosis occurred , and expression levels of [Fas] , FasL , and active caspase-3 were significantly *increased* compared with controls . Positive_regulation FAS FAS 19911702 2162171 In conclusion , our data indicate that decreased expression in OS cells is not secondary to DNA methylation of CpG islands in the Fas gene and that [Fas] expression can not be *increased* by using demethylation agents . Positive_regulation FAS FAS 22197557 2549638 We demonstrate a critical role for [FAS/FAS-L] ligation in responder T cell *induced* monocyte killing since responder T cells , but not Tregs , upregulate FAS-ligand (FAS-L) mRNA , and induce expression on monocytes . Positive_regulation FAS FAS 23760276 2820158 NMR and surface plasmon resonance data show that three CaM antagonists ( N- ( 6-aminohexyl ) -5-chloro-1-naphthalene sulfonamide , tamoxifen , and trifluoperazine ) greatly *inhibit* [Fas-CaM] interactions by blocking the binding site on CaM . Positive_regulation FAS FAS 8074235 270505 These data show that the increase in [FAS] activity in type IIB cells is an early response to silica , that it mediates the increase in cytidylyltransferase activity , and that it is not *due* to enhanced gene expression . Positive_regulation FAS FAS 8945627 400340 In this study we used the human breast-carcinoma cell line MCF7 , its derivatives MCF7Adr ( resistant to adriamycin ) and R-A1 ( resistant to TNF ) , to determine the impact of acquired drug and cytokine resistance on susceptibility to *induced* cytotoxicity and [Fas-antigen] expression . Positive_regulation FAS FAS 9096388 422526 In contrast , changes in Bcl-2 level due to expression of sense and antisense vectors influenced the sensitivity to [Fas] killing and induced JNK *activation* . Positive_regulation FAS FAS 9125577 426460 These results suggest that TNFRp55 but not [Fas] was involved in P. acnes induced granuloma formation as well as subsequent LPS induced liver injury and that TNFRp55 and independently *induced* apoptosis of hepatocytes in vivo . Positive_regulation FAS FAS 9697835 524733 Taken together , these data suggest that [Fas] has a novel role in the regulation of myelopoiesis and that may *act* as a tumor suppressor to control leukemogenic transformation in myeloid progenitor cells . Positive_regulation FAS FAS 9760568 536725 Under these conditions , the T cells co-express [Fas] ( CD95 ) and Fas ligand (FasL) , and engagement of *triggers* apoptotic death of the T cells . Positive_regulation FAS FASLG 10030292 591769 Finally , recombinant human FasL induced apoptosis in Fas expressing porcine EC cells , demonstrating that human interacted with and *activated* [Fas] on porcine EC cells . Positive_regulation FAS FASLG 10091108 600323 Virus infected hepatocytes bear [Fas] receptors and apoptosis is *induced* by binding to the which is expressed by activated T cells ; Positive_regulation FAS FASLG 10417181 631582 The expression of [Fas] and Fas ligand was immunohistochemically *detected* on renal tubular epithelial cells from GSR induced mice , although neither Fas nor was found in cells from untreated control mice or in cells from mice receiving a single injection of LPS . Positive_regulation FAS FASLG 10484385 644005 C. parvum stimulated FasL membrane surface translocation , increased both FasL and [Fas] protein expression in infected biliary epithelia , and *induced* a marked increase of soluble ( but not IL-1beta , TNF-alpha , and TGF-beta ) in supernatants from infected cells . Positive_regulation FAS FASLG 10579724 569900 Therefore , *activation* of [Fas] by endogenous underlies cell death induced by trophic deprivation . Positive_regulation FAS FASLG 10611305 575508 *Activation* of [Fas] by induces apoptosis by a mechanism that can not be blocked by Bcl-2 or Bcl-x ( L ) . Positive_regulation FAS FASLG 10653388 663201 Soluble anti-CD3epsilon F ( ab ' ) 2 did not regulate [Fas] or *induce* expression , indicating that the ability of anti-CD3epsilon F ( ab ' ) 2 to induce T cell apoptosis depends on a distinct mechanism . Positive_regulation FAS FASLG 10707926 673445 *Activation* of the [Fas] receptor by results in apoptosis , and dysregulation of this pathway may contribute to abnormal cell proliferation and cell death . Positive_regulation FAS FASLG 10714630 676321 *Activation* of the [Fas] receptor by results in apoptosis , and dysregulation of this pathway may contribute to abnormal cell proliferation . Positive_regulation FAS FASLG 10726692 677729 *Stimulation* of the [CD95-receptor] of the malignant glioblastoma cell line LN229 ( positive control ) with either anti-CD95-antibody or induced apoptosis . Positive_regulation FAS FASLG 10899765 712401 FasL was detected in infiltrating mononuclear cells , and [Fas] was *detected* in infiltrating mononuclear cells , alveolar macrophages , and epithelioid cells in HP , whereas was not detected and Fas was detected in few alveolar macrophages in controls . Positive_regulation FAS FASLG 10958304 724863 *induces* apoptosis of susceptible cells by cross linking its own receptor , [Fas] . Positive_regulation FAS FASLG 11104808 756535 [Fas] engagement *induces* the maturation of dendritic cells (DCs) , the release of interleukin (IL)-1beta , and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction : a new role for in inflammatory responses . Positive_regulation FAS FASLG 11435457 832517 The IL-12/IL-2 combination synergistically enhances cell surface expression on CD8 ( + ) T lymphocytes in vitro and *induces* [Fas] and FasL expression within tumors via an IFN-gamma dependent mechanism in vivo . Positive_regulation FAS FASLG 11594580 869994 Despite surface expression of [Fas] on tumor cells and *induction* on TC5 and TC7 cell membrane after coculture with autologous tumor cells , the CD4+ CTL clones did not use this cytotoxic mechanism to lyse their specific target . Positive_regulation FAS FASLG 11675354 873164 In some leukemia cell lines , cytotoxic drugs *induce* expression of , which may contribute to cell killing through the ligation of [Fas] . Positive_regulation FAS FASLG 11827997 909551 [Fas] *activation* by induced a hypertrophic response in cultured cardiomyocytes , which was dependent on the inactivation of glycogen synthase kinase 3 beta ( GSK3 beta ) by phosphorylation . Positive_regulation FAS FASLG 12370548 996033 [Fas] and Fas ligand (FasL) mediate apoptosis of tumor cells in immune surveillance , and expression of by tumors may *mediate* their counterattack on cytotoxic lymphocytes . Positive_regulation FAS FASLG 12393889 1025379 Membrane bound *induces* powerful [Fas] mediated signals because it possesses both Fas focusing and signal transducing functions . Positive_regulation FAS FASLG 12818572 1103848 *Activation* of [FasL/Fas] signaling by either recombinant membrane under normal culture conditions or H/R causes cardiomyocyte death mainly through the mitochondrial damage/caspase 9 activation pathway . Positive_regulation FAS FASLG 14499341 1143687 *Activation* of [Fas] receptor by causes caspase 8 activation and apoptosis in cells and is an important mechanism by which normal tissue homeostasis and function are maintained . Positive_regulation FAS FASLG 14625471 1170218 A rebound increase in [Fas] ( 30 % ) was seen on neutrophils at 24 h , and soluble levels *increased* by 100 % at 24 h . Fas mRNA levels increased 6-fold 4-6 h after endotoxin infusion as measured by real-time polymerase chain reaction . Positive_regulation FAS FASLG 14630709 1188074 Altogether , our results highlight the putative *role* of both membrane bound and soluble in oxLDL induced [Fas] and FADD dependent apoptosis of T lymphocytes and suggest an involvement of ROS , ERK , and JNK in this process . Positive_regulation FAS FASLG 14647441 1176732 FR901228 induces tumor regression associated with induction of and *activation* of [Fas] signaling in human osteosarcoma cells . Positive_regulation FAS FASLG 14679192 1211244 CD95-tyrosine nitration inhibits hyperosmotic and *induced* [CD95] activation in rat hepatocytes . Positive_regulation FAS FASLG 14738570 1242692 Because heterogeneity among endothelial cells from different tissues , has been demonstrated , the purpose of this study was to determine , if [Fas] ligation and/or *activation* by human induces apoptosis and caspase activities , in cultured human coronary artery endothelial cells , and the differences between TNF-a and FAS induced apoptosis in these cells . Positive_regulation FAS FASLG 14965271 1208864 For example , TNFalpha activates TNF-R1 while and TL1A *activate* [Fas] and DR3 respectively . Positive_regulation FAS FASLG 14988242 1215014 Thus , although Fas-L can lend some immune privilege to islet cells , local virus induced inflammation will *induce* [Fas] on beta-cells , leading to their mutual destruction if is present . Positive_regulation FAS FASLG 15272306 1276617 We now show that [CD95] *stimulation* of multiple apoptosis-resistant tumor cells by induces increased motility and invasiveness , a response much less efficiently triggered by TNFalpha or TRAIL . Positive_regulation FAS FASLG 15274324 1276705 These results indicate that [Fas] may play an important role , not only in development but also progression , and that is not always *required* for both development and progression in colorectal carcinomas . Positive_regulation FAS FASLG 15354026 1293018 After the treadmill tests [Fas] receptor expression was *enhanced* in both groups , whereas increased only after the ExT . Positive_regulation FAS FASLG 15536394 1336463 Expression of [Fas] , DR4 , and DR5 is *detected* on the cell membrane of erythroblasts in all stages , whereas and TRAIL are present only in more mature erythroblasts . Positive_regulation FAS FASLG 15685630 1370983 Modest [Fas] staining with no obvious change was *detected* throughout the menstrual cycle , while the levels of and Bax protein in the epithelial cells increased in the secretory phase when apoptosis was most prevalent . Positive_regulation FAS FASLG 15795317 1387174 Moreover , membrane *induced* [Fas] cluster formation occurred in the presence of the lipid raft destabilizing component methyl-beta-cyclodextrin , whereas Fas aggregation by soluble FasL was blocked . Positive_regulation FAS FASLG 15795317 1387175 Together , these data suggest that the extracellular domains of Fas and FasL alone are sufficient to drive membrane *induced* formation of supramolecular [Fas-FasL] complexes , whereas soluble FasL induced Fas aggregation is dependent on lipid rafts and mechanisms associated with the intracellular domain of Fas . Positive_regulation FAS FASLG 15996160 1430189 [Fas] receptor could be *detected* by flow cytometry , whereas the most resistant cell line ( M38K ) lacked when assessed by RT-PCR . Positive_regulation FAS FASLG 16187021 1462408 In astrocytoma cells , treatment *induces* tyrosine phosphorylation of [FAS] . Positive_regulation FAS FASLG 16222040 1469318 Apoptosis pathways are activated in the lungs of patients with acute lung injury , in part by *activation* of the membrane [Fas] death receptor by soluble ( sFasL ) , which accumulates in biologically active form at the onset of lung injury . Positive_regulation FAS FASLG 16237055 1470710 Both of these processes are initiated primarily by [Fas] stimulation rather than CD40 *activation* of DC via high expression of by the Vdelta1 T cells . Positive_regulation FAS FASLG 16565865 1574680 T cells expressing a type-2 T helper profile of cytokines ( Th2 cells ) have been demonstrated to play an important role in the initiation and progression of allergic asthma , and it is well known that *induces* apoptosis when bound to its receptor , [Fas] . Positive_regulation FAS FASLG 17474894 1738359 The expressions of on Th1 and Tc1 *increased* sharply vs . [Fas] , whereas the expressions of Fas on Th2 and Tc2 increased obviously vs . FasL . Positive_regulation FAS FASLG 17761170 1794973 binds [Fas] ( CD95 ) to *induce* apoptosis or activate other signaling pathways . Positive_regulation FAS FASLG 18620901 2010609 This upregulation of surface expression *increased* preexisting [Fas-sensitivity] only , but failed to make primarily resistant cell lines undergo Fas mediated growth reduction or apoptosis . Positive_regulation FAS FASLG 19276446 2051441 Immunoprecipitation and Western blot analysis of transfected HEK and BJAB cells revealed that wild-type K1 but not Ig-deleted K1 binds to Fas and prevents [Fas] *activation* by or by an agonistic Fas antibody . Positive_regulation FAS FASLG 19830835 2196050 *Activation* of [Fas] by recombinant did not induce apoptosis in murine NPCs in culture . Positive_regulation FAS FASLG 19902128 2161766 The results showed that the expression of [Fas] in NP cells was significantly *increased* by the recombinant . Positive_regulation FAS FASLG 20298688 2259901 Fas interaction at the plasma membrane with its lipid and protein environment plays a crucial role in the early steps of [Fas] signalling *induced* by binding . Positive_regulation FAS FASLG 20422450 2274543 Our data suggest that the impairment of the Na ( + ) -K ( + ) -ATPase activity during apoptosis is linked to perturbations in cell Ca ( 2+ ) homeostasis that modulate apoptosis induced by the *activation* of [Fas] by . Positive_regulation FAS FASLG 20828573 2325282 In 3T3-L1 adipocytes , *activation* of [Fas] by decreased insulin stimulated glucose uptake , without affecting cell viability . Positive_regulation FAS FASLG 22751926 2639420 Stimulation with rapidly *induced* associations of [Fas] with ERp57 and glutathione S-transferase p ( GSTP ) , a protein disulfide isomerase and catalyst of S-glutathionylation , respectively , in the ER . Positive_regulation FAS FASLG 23144495 2707412 [Fas] , a TNF family receptor , is *activated* by the membrane protein expressed on various immune cells . Positive_regulation FAS FASLG 7489709 332292 [Fas] is a type I membrane protein and its activation by binding of the or an agonistic anti-Fas antibody *induces* apoptosis in Fas bearing cells . Positive_regulation FAS FASLG 8838700 386603 Because ligation of Fas can result in costimulation of proliferation or the induction of apoptosis in uninfected cells , we evaluated the effect on T cells of [Fas] activation by monoclonal antibodies ( MAb ) of different specificity from both UB2 and CH11 clones and *activation* by the . Positive_regulation FAS FASLG 9050377 417042 This article reviews progress in deciphering the mechanisms by which they kill target cells through induction of apoptosis by either the secretory , perforin/granzyme based pathway or the nonsecretory pathway , ( i.e. , by *triggering* the cell-surface death receptor [Fas] ( CD95 ) by the membrane bound of the killer ) . Positive_regulation FAS FASLG 9137215 427914 [Fas] on the cell membrane *induces* apoptosis when it binds or sFas-L . Positive_regulation FAS FASLG 9257699 448480 [Fas] ( Apo-1/CD95 ) , a receptor belonging to the tumor necrosis factor receptor family , *induces* apoptosis when triggered by . Positive_regulation FAS FASLG 9384699 408096 Despite the induction of expression of CD95 ( all cases of AML and most cell lines ) , 7/8 myelogenous leukemia lines and 6/7 patient samples remained resistant to [CD95] *triggering* by antibody or by , which suggests a lesion in normal cell signaling . Positive_regulation FAS FASLG 9407341 470905 The [Fas] system mediated death signal *requires* the interaction of with Fas on target cells . Positive_regulation FAS FASLG 9413263 471598 When the cell surface molecule [Fas] is *triggered* by its agonist the result is apoptosis of these cells and tissue destruction . Positive_regulation FAS FASLG 9461339 475809 Some cytostatic drugs used in chemotherapy kill their target cells by upregulating expression of [Fas] and *inducing* expression in the same cell by different mechanisms . Positive_regulation FAS FASLG 9506704 491450 To investigate the mechanism ( s ) underlying CTL damage to the myocardium through *activation* of the [Fas] receptor ( Fas/CD95/Apo-1 ) by the , we explored the interaction between peritoneal exudate CTLs ( PELs ) , derived from perforin gene-knockout ( P-/- ) mice , and murine ventricular myocytes . Positive_regulation FAS FASLG 9699548 525132 Retinal pigment epithelial cells express and *induce* TCR independent apoptosis in activated human T cells through [Fas-FasL] interaction . Positive_regulation FAS FASLG 9780248 540526 In investigation of CD95 based apoptosis , tRA had no effect on activation dependent induction of [CD95] on T lymphocytes , but it *inhibited* the induction of expression on anti-CD3 activated T cells . Positive_regulation FAS FASLG 9831564 551491 ( CD95L ) inhibits T cell function in immune privileged organs such as the eye and testis , yet in most tissues [CD95L] expression *induces* potent inflammatory responses . Positive_regulation FAS FCGR3B 9292524 452805 On the other hand , the [CD95] expression *induced* by stimulation was blocked by staurosporine , but not by EGTA or FK506 , and phorbol myristate acetate ( PMA ) induced CD95 expression in the same manner as Fc gammaRIII , indicating the involvement of PKC in the CD95 expression induced by Fc gammaRIII stimulation . Positive_regulation FAS FLOT2 23671449 2785118 Meanwhile , reduced the serum IL-6 and TNF-a levels ( p < 0.05 ) , inhibited the expression of PCNA and *promoted* the expression of caspase-3 , [Fas] and FasL in animals of the treated group ( p < 0.05 ) . Positive_regulation FAS FOXP3 21746966 2461751 Our study reveals that negatively *regulates* [CD95L] expression in Tregs and demonstrates that Tregs are susceptible to homeostatic control by CD95 stimulation . Positive_regulation FAS FXR1 16957179 1646603 We show that specifically binds to the FAS IR-1 and that the [FAS] promoter is *activated* approximately 10-fold by the addition of a synthetic FXR agonist in transient transfection assays . Positive_regulation FAS FXR1 16957179 1646605 Furthermore , we show that feeding wild-type mice a chow diet supplemented with the natural agonist chenodeoxycholic acid *results* in a significant induction of [FAS] mRNA expression . Positive_regulation FAS FXR2 16957179 1646604 We show that specifically binds to the FAS IR-1 and that the [FAS] promoter is *activated* approximately 10-fold by the addition of a synthetic FXR agonist in transient transfection assays . Positive_regulation FAS FXR2 16957179 1646606 Furthermore , we show that feeding wild-type mice a chow diet supplemented with the natural agonist chenodeoxycholic acid *results* in a significant induction of [FAS] mRNA expression . Positive_regulation FAS GDA 21227941 2386699 *up-regulated* the expression of [Fas] and inhibited ERK activation in the Th-1 cells , which might enhance the vulnerability of the cells to cell death caused by a trophoblast derived FasL . Positive_regulation FAS GLA 15138577 1246214 Western blotting studies showed that down-regulation of FAS protein expression tightly correlated with previously observed inhibition of FAS activity , suggesting that ALA- , DHA- , and *induced* changes in [FAS] activity resulted from effects at the protein level . Positive_regulation FAS GNRH1 24622841 2930163 In addition , siRNA mediated knockdown of p53 diminished *induced* [Fas] expression and caspase-8 activation . Positive_regulation FAS GRAP2 10871852 708318 Forced expression of a dominant negative form of ( p38-ASP ) or treatment with p38 pharmacological inhibitor , SB203580 , *increases* NF-kappaB activity , [Fas] expression and the levels of UVC induced apoptosis in late stage melanoma cells . Positive_regulation FAS GRAP2 15601669 1375280 By using specific inhibitors for each MAPK , we confirmed the pivotal role of the IkappaB/NF-kappaB system by demonstrating that ERKs , , and JNK are not *involved* in [Fas] up-regulation by TNF-alpha . Positive_regulation FAS GRAP2 19009558 2016528 Activated ERK was found to attenuate MAPK *mediated* upregulation of [Fas] and FasL . Positive_regulation FAS GRAP2 22505709 2607743 Inhibition of and NF-?B activity by SB203580 and/or CAPE *reduced* [Fas] expression and apoptosis in salivary epithelial cells , establishing p38MAPK and NF-?B as proapoptotic factors in this context . Positive_regulation FAS GRAP2 8972182 408505 [Fas] *activation* of correlated temporally with the onset of apoptosis , and transfection of constitutively active MKK3 ( glu ) , an upstream regulator of p38 , potentiated Fas induced cell death , suggesting a potential involvement of the MKK3/p38 activation pathway in Fas mediated apoptosis . Positive_regulation FAS GRAP2 8972182 408509 In this study , crmA antagonized , and YVAD-CMK and Z-VAD-FMK completely inhibited , [Fas] *activation* of kinase activity , demonstrating that Fas dependent activation of p38 requires ICE/CED-3 family members and conversely that the MKK3/p38 activation cascade represents a downstream target for the ICE/CED-3 family proteases . Positive_regulation FAS GUCY2D 19054763 2023914 also *induced* increased [CD95] localization to the plasma membrane and generated increased reactive oxygen species compared with ent-LCA . Positive_regulation FAS GUCY2D 19054763 2023916 This suggests that *induce* apoptosis enantioselectively through [CD95] activation , likely because of increased reactive oxygen species generation , with resulting procaspase-8 cleavage . Positive_regulation FAS GZMB 17649632 1775856 <5C11> significantly *up-regulated* [FAS] expression in Daudi cells , but had no significant effect on apoptosis rate of Daudi cells . Positive_regulation FAS HBB 21266189 2398131 In addition , the results showed that *promoted* the up-regulation of [Fas] prior to the processing and activation of pro-caspase-8 and cleavage of Bid , suggesting the involvement of a Fas mediated pathway in HBA induced cells . Positive_regulation FAS HDAC1 22517765 2613373 Butyrate suppresses colonic inflammation through *dependent* [Fas] upregulation and Fas mediated apoptosis of T cells . Positive_regulation FAS HGF 23152012 2699757 Several acquired-resistance mechanisms and candidates , including exon 20 T790M secondary mutation , MET amplification , a high-level of expression , PTEN downregulation , [FAS-NF-?B] pathway *activation* , epithelial-mesenchymal transition , and conversion to small cell lung cancer , have been identified . Positive_regulation FAS HLA-DRB1 16800817 1612719 HNF-4alpha transactivates reporter constructs containing the distal FAS promoter in a DR-1 dependent manner , and this is *required* for full glucose induction of the [FAS] promoter in primary hepatocytes . Positive_regulation FAS HMGB1 20565784 2285287 [Fas] ( CD95 ) *induces* rapid , TLR4/IRAK4 dependent release of pro-inflammatory from macrophages . Positive_regulation FAS HMGB1 20565784 2285290 We conclude that [Fas] activation *induces* rapid , TLR4/IRAK4 dependent release of that contributes to Fas mediated pro-inflammatory cytokine production by viable macrophages . Positive_regulation FAS HMGCR 6838700 27845 The inhibition of and the *induction* of [FAS] by AMO 1618 were tested in vitro , using 10 -- 100 micrograms ( 28 -- 280 mumoles ) for 15 min with isolated hepatocytes from chicken and rat . Positive_regulation FAS HNF4A 16800817 1612720 transactivates reporter constructs containing the distal FAS promoter in a DR-1 dependent manner , and this DR-1 is *required* for full glucose induction of the [FAS] promoter in primary hepatocytes . Positive_regulation FAS HNRNPF 10698621 671898 Stimulation of T cells with at an S/R ratio of 5 *induced* a higher level of expression of [CD95 ligand (CD95L)] than stimulation of T cells cultured with DCs at an S/R ratio of 0.5 , whereas similar levels of expression of CD28 and CD154 were observed in both cells . Positive_regulation FAS HNRNPF 23943615 2845255 Here , we show that CD11b ( hi ) Ia ( low ) regulatory expressed high level of Fas , and endothelial stromal cell derived TGF-ß could *induce* high expression of [Fas] on regulatory DCs via ERK activation . Positive_regulation FAS HNRNPF 23943615 2845272 Furthermore , [Fas] ligation preferentially *induced* regulatory to produce IL-10 and IP-10 via ERK mediated inactivation of GSK-3 and subsequent up-regulation of ß-catenin . Positive_regulation FAS HNRNPH1 10698621 671899 Stimulation of T cells with at an S/R ratio of 5 *induced* a higher level of expression of [CD95 ligand (CD95L)] than stimulation of T cells cultured with DCs at an S/R ratio of 0.5 , whereas similar levels of expression of CD28 and CD154 were observed in both cells . Positive_regulation FAS HNRNPH1 23943615 2845256 Here , we show that CD11b ( hi ) Ia ( low ) regulatory expressed high level of Fas , and endothelial stromal cell derived TGF-ß could *induce* high expression of [Fas] on regulatory DCs via ERK activation . Positive_regulation FAS HNRNPH1 23943615 2845273 Furthermore , [Fas] ligation preferentially *induced* regulatory to produce IL-10 and IP-10 via ERK mediated inactivation of GSK-3 and subsequent up-regulation of ß-catenin . Positive_regulation FAS HRG 17539658 1762285 We identified that , a HER3 ligand , *stimulated* dose dependent [FAS] expression in breast cancer cell lines MCF-7 and AU565 , but not MDA-MB-453 . Positive_regulation FAS HRG 17539658 1762286 Treatment of MCF-7 cells with EGCG markedly inhibited *dependent* induction of mRNA and protein of [FAS] . Positive_regulation FAS HRG 17539658 1762288 [FAS] *induction* by was also blocked by AG825 , a selective HER2 inhibitor , and by genistein , a selective tyrosine kinase inhibitor , indicating the formation of a heterodimer between HER2 and HER3 , and their tyrosine kinase activities are essential for HRG-beta1 mediated elevation of FAS . Positive_regulation FAS HSD17B8 19571038 2149709 Notably , 17beta-HSD8 was previously classified as a steroid metabolizing enzyme , but our data suggest that <17beta-HSD8> is primarily *involved* in mitochondrial [FAS] . Positive_regulation FAS HSPG2 11007187 735381 In an attempt to correlate the existence of activity and *activation* of PLD by [Fas] activation among various Fas expressing murine cell lines , we have investigated the effect of anti-Fas monoclonal antibody on PC-PLC and PLD activities in A20 , P388D1 and YAC-1 cell lines . Positive_regulation FAS IAPP 19843871 2299413 These data demonstrate that [FAs] differently regulate amylin and insulin expression and *induce* both and insulin release . Positive_regulation FAS ICAM1 14615040 1163685 We demonstrate that [Fas] ligation *induces* expression at the mRNA and protein levels in human astroglioma cells . Positive_regulation FAS IFNB1 11698494 878129 Stimulation of the cells with in vitro *resulted* in an even further increase of annexin V binding , as well as increased [Fas] ( CD 95 , APO-1 ) expression . Positive_regulation FAS IFNB1 1371136 179600 The expression of the [Fas] antigen gene in mouse fibroblast L929 and macrophage BAM3 cell lines was significantly *induced* by treatment with IFN-gamma but not by . Positive_regulation FAS IFNG 10037193 592084 FUra/LV induced cytotoxicity was significantly potentiated by IFN-gamma , reversed by exposure to NOK-1+NOK-2 antibodies , and correlated with a 4-fold induction of [Fas] expression in the *presence* of and significant elevation in expression of FasL . Positive_regulation FAS IFNG 10200533 561154 *induced* an upregulation of [Fas] receptor expression and pre-treatment of cells with IFN-gamma led to enhanced anti-Fas mediated cell death . Positive_regulation FAS IFNG 10208842 607094 Caspase-1 expression was little detected in hepatocytes , and constitutive and *induced* mRNA expression of [Fas] or caspase-3 did not change in between wild type and IRF-1-deficient hepatocytes . Positive_regulation FAS IFNG 10457352 639313 In colonic organ cultures , and TNFalpha also *enhanced* colonocyte [FAS] expression , resulting in a markedly increased apoptotic response to stimulation of this receptor , as shown by in situ terminal deosyuridine triphosphate nick-end staining . Positive_regulation FAS IFNG 10576768 569495 However , in contrast to results of recent in vitro studies , in the BB/W rat [Fas/FasL] expression is not *regulated* by IL-2 , -4 , -6 , -10 , -12 , , and tumor necrosis factor alpha . Positive_regulation FAS IFNG 10632976 659840 It has previously been shown that and tumour necrosis factor-alpha (TNF-alpha) together *increase* [CD95] surface expression on eosinophils . Positive_regulation FAS IFNG 10632976 659842 We therefore investigated whether the increase in [CD95] expression *mediated* by indeed translates into increased , FasL mediated apoptosis of eosinophils . Positive_regulation FAS IFNG 10632976 659844 This increase in CD95/FasL mediated apoptosis was correlated with an mediated *increase* in [CD95] expression . Positive_regulation FAS IFNG 10651943 662562 In four breast cancer cell lines , [CD95L] expression was *increased* by , which resulted in higher levels of CD95L-specific apoptosis in co-cultured Jurkat T cells . Positive_regulation FAS IFNG 10733554 678456 *augmented* [Fas] expression and Fas mediated cell death , respectively . Positive_regulation FAS IFNG 10739635 679727 induces apoptosis and *augments* the expression of [Fas] and Fas ligand by microglia in vitro . Positive_regulation FAS IFNG 10739635 679729 Flow cytometry was used to quantify the *mediated* apoptotic response and [Fas] and Fas ligand (FasL) expression in two well characterized murine microglia cell lines ( BV-2 and N9 ) . Positive_regulation FAS IFNG 10739635 679848 These findings suggest that in addition to its role as a microglia activator , may also *induce* apoptosis of microglia , possibly through simultaneous upregulation of [Fas] and FasL . Positive_regulation FAS IFNG 10811232 693017 Like pancreatic beta cells , betaTC-3 cells do not constitutively express [Fas] , but Fas expression can be *induced* with IL-1 and . Positive_regulation FAS IFNG 10845905 700694 *induced* [Fas] expression of the cells without the activation of caspase8 or caspase3 during 16 hours of incubation , while deprivation of EPO induced expression of Fas and the activation of both caspase8 and caspase3 . Positive_regulation FAS IFNG 10880045 709080 KCs normally express low levels of [Fas receptor (FasR)] that can be substantially *enhanced* by the presence of . Positive_regulation FAS IFNG 10895367 711570 Our findings suggest that or TNF-alpha secreted by infiltrating lymphocytes *induces* ductal [Fas] expression and ductal apoptosis in sialoadenitis associated with SS . Positive_regulation FAS IFNG 11315506 806413 increased the mRNA expression of Fas , TRAIL and caspase-1 , and surface [Fas] was also *increased* . Positive_regulation FAS IFNG 11414736 829016 The *promoted* significant upregulation of [Fas] on the surface of colon carcinoma cells and sensitized these targets to Fas mediated apoptosis and Ag-specific CD8 ( + ) cytotoxic T lymphocyte ( CTL ) -mediated lysis involving a Fas based effector mechanism . Positive_regulation FAS IFNG 11464861 839440 To evaluate a possible role of the CD95/CD95L system in human neuroblastoma ( NB ) cells , we investigated the constitutive and *induced* expression of [CD95] and CD95L , and CD95 mediated cell death in the SK-N-BE ( 2 ) cell line . Positive_regulation FAS IFNG 11464861 839441 Modulation of [CD95/CD95L] expression and *triggering* of an autocrine apoptotic mechanism by suggest a potential role for INFgamma as a therapeutic agent for NB . Positive_regulation FAS IFNG 11520076 851906 Parental autologous and HLA-DR matched allogeneic melanoma cell lines , displaying low levels of HLA-DR antigens , induced Th2 proliferation and cytokine release , but were insensitive to lysis prior to *upregulation* of HLA-DR and [Fas] antigens by . Positive_regulation FAS IFNG 11591123 869408 Dexamethasone inhibited the *upregulation* of [Fas] and FasL by and the induction of SGEC apoptosis and detachment by anti-Fas mAb or IFN-gamma . Positive_regulation FAS IFNG 11595074 870105 Flow cytometric analysis demonstrated that significantly *enhanced* [Fas] Ag expression . Positive_regulation FAS IFNG 11692113 876420 released from activated T cells *upregulates* [Fas] on ke-ratinocytes , which renders them susceptible to apoptosis . Positive_regulation FAS IFNG 11739498 886507 Moreover , an in vivo blockade of TNF-alpha preferentially inhibited the production of IFN-gamma and blocked *dependent* up-regulation of [Fas] ; Positive_regulation FAS IFNG 11895550 920765 The data indicate that the FasL expression of gastric cancer cells supports a ` counterattack theory ' in gastric cancer cells and that the *upregulation* of [Fas] by in SNU-638 may accelerate the apoptosis pathway through the Fas and FasL interaction between gastric cancer cells and immune cells . Positive_regulation FAS IFNG 11948376 930124 After demonstrating that Ad.HSV-tk/GCV and Ad.mIL-12 induced independently *up-regulated* expression of FasL and [Fas] , respectively , studies examined tumor cell mediated death through Fas/FasL induced apoptosis as a mechanism of primary tumor growth suppression . Positive_regulation FAS IFNG 12021072 942783 and TNFalpha *promote* [Fas] expression and sensitivity , whereas IL-6 and IL-10 increase the resistance of trophoblast cells to Fas mediated apoptosis . Positive_regulation FAS IFNG 12077239 957031 This [Fas] up-regulation on initially Fas negative target cells is not *mediated* by TCR-MHC/peptide signaling per se , but by secreted from Tc cells after Ag engagement . Positive_regulation FAS IFNG 12096925 961229 *increases* the expression of glycosylated [CD95] in B-leukemic cells : an inducible model to study the role of glycosylation in CD95 signalling and trafficking . Positive_regulation FAS IFNG 12096925 961230 However , the *induced* increases of [CD95] on the cell surface were not altered by treatment with any of the glycosidase inhibitors , suggesting that the generation of complex oligosaccharide structures is not required for trafficking of CD95 , but may instead be used as a mechanism of partially blocking CD95 signalling in these cells . Positive_regulation FAS IFNG 12480581 1024221 [Fas] expression was *up-regulated* by ( P < 0.05 ) , which alone was enough to induce apoptosis in tumor cells and increase the susceptibility of them to anti-Fas antibodies . Positive_regulation FAS IFNG 12480581 1024222 *induced* [Fas] expression up-regulation and tumor cell apoptosis in a time dependent manner . Positive_regulation FAS IFNG 12484048 1024852 These results suggest that [Fas] was expressed , apoptosis was induced by CH-11 and the induction of apoptosis was *enhanced* by in human bile duct carcinoma cells . Positive_regulation FAS IFNG 12513829 1027773 Tumor necrosis factor-alpha (TNF-alpha) and further *increased* the [CD95] expression induced by positive cytokines . Positive_regulation FAS IFNG 12629330 1067353 *up-regulated* [Fas] mRNA levels . Positive_regulation FAS IFNG 12787425 1097007 *increased* the cell surface expression of [Fas] and the sensitivity of mesothelial cells to FasL induced apoptosis . Positive_regulation FAS IFNG 14646476 480064 *enhanced* the expression of [Fas] antigen in all of the cell lines examined . Positive_regulation FAS IFNG 14648016 1201912 Our results showed that *upregulates* [Fas] in PBMC in vivo and in HT29 cells in vitro at tolerable , clinically relevant exposures and that monitoring IFN-gamma pharmacokinetics/pharmacodynamics may be warranted in IFN-gamma clinical use . Positive_regulation FAS IFNG 15015631 1183067 However , *up-regulated* [Fas] expression of CD34+ cells and increased the sensibility of CD34+ cells to soluble FasL ( sFasL ) ; Positive_regulation FAS IFNG 15033908 1244019 The effect of FasL on NIT-1 cells was evident during and after the *induction* of [Fas] expression by IL-1beta and . Positive_regulation FAS IFNG 15100317 1239742 SOCS-1 appeared to protect at least in part by inhibiting TNF- and *induced* [Fas] expression on beta cells . Positive_regulation FAS IFNG 15123769 1272991 *induced* an increase in the expression of [Fas] and FasL by allergen stimulated CD4+ T cells from asthmatic patients and caused the apoptosis of these cells . Positive_regulation FAS IFNG 15160396 1252760 In addition to direct cytotoxic effects , and TNF-alpha also *enhance* the expression of [Fas] , TNFR1 , and MHC class I molecules in both cell lines . Positive_regulation FAS IFNG 15240678 1270198 Thus , both dependent *induction* of [Fas/FasL] and IFN-gamma independent induction of perforin contribute to CTL mediated elimination of host B cells in AGVHD . Positive_regulation FAS IFNG 16723718 1565504 also *increased* Fas induced apoptosis in vivo 7.5- to 15-fold ( P < 0.05 ) in human arteries transplanted into immunodeficient mice , accompanied by increased [Fas] and phospho-Ser727-Stat1 . Positive_regulation FAS IFNG 17878376 1797002 In addition , disruption of constitutively expressed IRF8 function diminished JAK1 expression and thereby inhibited IFN-gamma initiated induction of STAT1 phosphorylation , which in turn , blocked *induced* [Fas] up-regulation . Positive_regulation FAS IFNG 17900305 1824074 and LPS *augmented* cell surface expression of [Fas] , but not tumour necrosis factor (TNF) receptor 1 . Positive_regulation FAS IFNG 17962369 1844770 Finally , *induced* but not basal [FAS] mRNA levels were increased significantly ( P=0.049 ) in PBMCs from AA versus GG individuals , demonstrating the IFN dependent functionality of the -670 polymorphism . Positive_regulation FAS IFNG 18777493 1962936 *Induction* of [Fas] by coupled with activation by Super-FasL augmented cytokine induced cell death . Positive_regulation FAS IFNG 19002429 2022196 In INS-1 cells , IL-1beta + induced a tenfold and eightfold *increase* of [Fas] mRNA expression after 6 and 24 h , respectively . Positive_regulation FAS IFNG 19400895 2089517 and TNF-alpha *up-regulated* TNFR1 , TNFR2 , [Fas] and membrane FasL on SMC . Positive_regulation FAS IFNG 19740320 2134628 In vitro culturing of muscle cells with the proinflammatory cytokines , tumour necrosis factor-alpha , and interleukin (IL)-1beta synergistically *increased* [Fas] expression , susceptibility to Fas mediated apoptosis , and the expression of cytoplasmic caspases 8 and 3 . Positive_regulation FAS IFNG 7507000 244483 *increased* the surface expression of [Fas] antigen and susceptibility to anti-Fas Ab-induced cell death of B104 and U937 cells . Positive_regulation FAS IFNG 7538820 306901 [Fas] antigen expression on CD34+ human marrow cells is *induced* by and tumor necrosis factor alpha and potentiates cytokine mediated hematopoietic suppression in vitro . Positive_regulation FAS IFNG 7538820 306904 [Fas] antigen expression on lymphocytes is *regulated* by and tumor necrosis factor alpha (TNF alpha) , cytokines that also have inhibitory effects on hematopoiesis . Positive_regulation FAS IFNG 7538820 306908 Stimulation by TNF alpha and markedly *increased* [Fas] antigen expression on CD34+ cells . Positive_regulation FAS IFNG 7542501 314115 However , and/or TNF-alpha *induced* the expression of both the mRNA of Fas and [Fas] itself in a dose dependent fashion on the surface of CD34+ cells after 48 hours of serum-free culture . Positive_regulation FAS IFNG 7542501 314118 and TNF-alpha *had* a synergistic effect on the induction of [Fas] , when both cytokines were added to the culture . Positive_regulation FAS IFNG 7542501 314126 These observations indicate that and/or TNF-alpha , well known as negative hematopoietic regulators , *induce* functional [Fas] on hematopoietic progenitor cells . Positive_regulation FAS IFNG 7577642 333276 and tumour necrosis factor-alpha (TNF-alpha) , potent inhibitors of haemopoiesis , *enhance* [Fas] receptor expression on bone marrow ( BM ) CD34+ cells , and both cytokines render haemopoietic progenitor cells susceptible to Fas mediated inhibition of colony formation due to the induction of apoptosis . Positive_regulation FAS IFNG 7693996 234256 Expression of [APO-1] was *induced* in phytohemagglutinin activated T cells and in a mammary carcinoma cell line by alone and in combination with tumor necrosis factor alpha . Positive_regulation FAS IFNG 8612534 353168 Finally , we found that *increased* [Fas] expression on granulosa cells in vitro . Positive_regulation FAS IFNG 8741668 377114 However , and/or tumor necrosis factor-alpha (TNF-alpha) *induced* the expression of [Fas] after 48 hours of serum-free culture . Positive_regulation FAS IFNG 8822920 384851 Tumor necrosis factor-alpha (TNF-alpha) and further *increased* the [CD95] expression induced by KL+GM-CSF . Positive_regulation FAS IFNG 8945627 400341 While MCF7 and R-A1 cells were killed by [anti-Fas] in the *presence* of , MCF7Adr was found to be resistant to Fas mediated apoptosis . Positive_regulation FAS IFNG 9028327 413475 We have previously shown that *induces* [Fas-R] expression on CD34+ cells ; Positive_regulation FAS IFNG 9049961 406021 However , and/or tumor necrosis factor-alpha (TNF-alpha) *induced* dose dependent expression of both Fas mRNA and [Fas] protein on the surface of CD34+ cells after 48 hours of serum-free culture . Positive_regulation FAS IFNG 9163602 432082 CD34+ cell [Fas-R] expression was *increased* by and TNF-alpha . Positive_regulation FAS IFNG 9351390 461134 In culture , stimulation with , tumor necrosis factor-alpha , and interleukin-1 beta *increased* expression of [Fas] in SMCs . Positive_regulation FAS IFNG 9389691 467161 both inhibits cell cycling and *induces* expression of the [Fas-receptor] , resulting in subsequent apoptosis of hematopoietic progenitor cells . Positive_regulation FAS IFNG 9401054 469428 [Fas-receptor (Fas-R)] expression can be *stimulated* by and TNF-alpha . Positive_regulation FAS IFNG 9454753 484346 Fas ligand is present in human erythroid colony forming cells and interacts with [Fas] *induced* by to produce erythroid cell apoptosis . Positive_regulation FAS IFNG 9485203 488249 Furthermore , macrophages infected with L. major in vitro up-regulate their surface expression of [Fas] in *response* to and as a result become susceptible to CD4+ T cell induced apoptotic death . Positive_regulation FAS IFNG 9661898 518183 Here we report that *up-regulated* the expression of [Fas] and Fas ligand (FasL) on HT29 cells , a human colon adenocarcinoma cell line , and subsequently induced apoptosis of these cells . Positive_regulation FAS IFNG 9661898 518185 We further show that *up-regulated* the expression of [Fas] and FasL in STAT1 transfected U3A cells but not in STAT1-deficient U3A cells . Positive_regulation FAS IFNG 9690515 523045 First , *increased* the [CD95] cell surface expression while MycN enhanced the cellular susceptibility for the CD95 mediated death signal . Positive_regulation FAS IFNG 9743345 532382 Differential expression of [Fas] and Fas ligand in acute and chronic graft-versus-host disease : up-regulation of Fas and Fas ligand *requires* CD8+ T cell activation and production . Positive_regulation FAS IFNG 9743345 532394 Thus , in this in vivo model of alloantigen immune responsiveness , [Fas/FasL] up-regulation is critically *dependent* on Ag-specific ( donor ) CD8+ T cell activation and production . Positive_regulation FAS IFNG 9823934 549025 About 30 % of unstimulated PBLs expressed [Fas] , and the expression was *augmented* by interleukin-1beta (IL-1beta) , IL-2 , tumor necrosis factor-alpha (TNF-alpha) , , or PMA plus ionomycin . Positive_regulation FAS IGF1 20356977 2260916 Abundance of [FAS] was higher in malignant cells than in non-malignant cells , and was *up-regulated* by in both cell types . Positive_regulation FAS IGF1 8912704 395437 Moreover , both and insulin *increased* the [FAS] gene transcription rate at 2 h , producing a time dependent accumulation of FAS mRNA . Positive_regulation FAS IGF1 9636651 513375 Both [Fas] expression and the degree of anti-Fas IgM induced apoptosis of human osteoblasts was also *augmented* by . Positive_regulation FAS IGF1 9636651 513376 Furthermore , the cytotoxicity of Fas ligand (FasL) cDNA transformants against human osteoblasts was increased when IGF-I stimulated osteoblasts were used as target cells , indicating that stimulation of *increased* functional [Fas] expression on human osteoblasts as well as their proliferation . Positive_regulation FAS IL10 16609999 1545258 The expression of [Fas] and FasL is increased in the course of liver fibrosis , and is further *increased* by . Positive_regulation FAS IL10 17199973 1663130 IL-1beta and *had* no significant effect on the basal [Fas] mRNA expressions in both GES-1 and AGS cells ( all P > 0.05 ) . Positive_regulation FAS IL10 8932996 398066 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL11 8932996 398067 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL12A 11358827 816132 Infection of the LM6 cells with an adenoviral vector containing the murine interleukin (IL)-12 gene ( AD : mIL-12 ) or treatment with recombinant murine IL-12 resulted in a dose dependent up-regulation of FAS : The *up-regulation* of [Fas] by was also demonstrated in human etoposide-resistant MDA-MB-231 breast cancer cells . Positive_regulation FAS IL12A 11877485 919103 In contrast , CD4 ( + ) CD1d restricted NKT cells potently produced both Th1 and Th2 cytokines , up-regulated perforin in *response* to stimulation by phorbol myristate acetate and ionomycin but not IL-2 or , and could be induced to express [CD95L] . Positive_regulation FAS IL12A 16380506 1493733 In this study , we further examined the mechanism of IL-12 antitumor activity and showed that significantly *increased* [Fas] expression in both human osteosarcoma cells LM7 and Ewing 's sarcoma cells TC71 . Positive_regulation FAS IL12A 16875741 1613660 We previously reported that the proinflammatory cytokine *induced* apoptosis in TNF-alpha mediated osteoclastogenesis in mouse bone marrow culture through an interaction of [Fas] and Fas ligand (FasL) . Positive_regulation FAS IL12A 19651258 2138493 These results suggest that inhibits TNF-alpha mediated osteoclastogenesis and *induces* apoptotic changes through an interaction between TNF-alpha induced [Fas] and IL-12 induced FasL , in vivo , via a T cell independent mechanism . Positive_regulation FAS IL12A 21479379 2009692 SOCS1 silencing in DCs could prevent immune tolerance by inhibiting [Fas] and Fas-L expression , *induced* by an increase in and IL-6 production . Positive_regulation FAS IL12A 9199873 438998 IL-2 and IL-7 equally *enhanced* the [Fas] expression in the CD56+CD3+ population , while had a less pronounced effect . Positive_regulation FAS IL12B 11358827 816133 Infection of the LM6 cells with an adenoviral vector containing the murine interleukin (IL)-12 gene ( AD : mIL-12 ) or treatment with recombinant murine IL-12 resulted in a dose dependent up-regulation of FAS : The *up-regulation* of [Fas] by was also demonstrated in human etoposide-resistant MDA-MB-231 breast cancer cells . Positive_regulation FAS IL12B 11877485 919104 In contrast , CD4 ( + ) CD1d restricted NKT cells potently produced both Th1 and Th2 cytokines , up-regulated perforin in *response* to stimulation by phorbol myristate acetate and ionomycin but not IL-2 or , and could be induced to express [CD95L] . Positive_regulation FAS IL12B 16380506 1493734 In this study , we further examined the mechanism of IL-12 antitumor activity and showed that significantly *increased* [Fas] expression in both human osteosarcoma cells LM7 and Ewing 's sarcoma cells TC71 . Positive_regulation FAS IL12B 16875741 1613661 We previously reported that the proinflammatory cytokine *induced* apoptosis in TNF-alpha mediated osteoclastogenesis in mouse bone marrow culture through an interaction of [Fas] and Fas ligand (FasL) . Positive_regulation FAS IL12B 19651258 2138494 These results suggest that inhibits TNF-alpha mediated osteoclastogenesis and *induces* apoptotic changes through an interaction between TNF-alpha induced [Fas] and IL-12 induced FasL , in vivo , via a T cell independent mechanism . Positive_regulation FAS IL12B 21479379 2009693 SOCS1 silencing in DCs could prevent immune tolerance by inhibiting [Fas] and Fas-L expression , *induced* by an increase in and IL-6 production . Positive_regulation FAS IL12B 9199873 438999 IL-2 and IL-7 equally *enhanced* the [Fas] expression in the CD56+CD3+ population , while had a less pronounced effect . Positive_regulation FAS IL13 8932996 398068 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL15 8932996 398069 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL16 8932996 398070 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL17A 15901616 1440274 also *increased* the expression of [Fas-antigen] in airway macrophages in vivo . Positive_regulation FAS IL17D 16670296 1558480 In anti-Ig stimulated naive or memory B cells , also *induced* CD54 , CD86 , and [CD95] surface expression . Positive_regulation FAS IL18 11464579 839438 *induces* [Fas] expression , whereas FADD is a constitutively expressed gene in human fetal membranes . Positive_regulation FAS IL18 21035858 2348998 However , high concentrations of IL-2 strongly blocked IL-18 induced NK cell apoptosis through alleviating *induced* FasL expression and activation of [Fas] mediated death signaling and increasing anti-apoptosis molecule ( Bcl-X ( L ) ) . Positive_regulation FAS IL18 8932996 398071 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL19 8932996 398072 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL1A 10504483 648931 These data are supported by in vitro studies that showed that or tumor necrosis factor-alpha , cytokines that are secreted in chronic renal failure , *stimulated* increases in [Fas] expression in cultured RTCs . Positive_regulation FAS IL1A 10504483 648932 Functional studies revealed that *stimulated* RTC [Fas] expression was accompanied by increased apoptosis , which was inhibited by blocking anti-Fas ligand antibodies . Positive_regulation FAS IL1A 10811232 693018 Like pancreatic beta cells , betaTC-3 cells do not constitutively express [Fas] , but Fas expression can be *induced* with and IFN-gamma . Positive_regulation FAS IL1A 14693705 1194896 action was not *required* for induction of class I major histocompatibility complex or [Fas] by TNF and IFN-gamma . Positive_regulation FAS IL1A 19740320 2134629 In vitro culturing of muscle cells with the proinflammatory cytokines interferon-gamma , tumour necrosis factor-alpha , and synergistically *increased* [Fas] expression , susceptibility to Fas mediated apoptosis , and the expression of cytoplasmic caspases 8 and 3 . Positive_regulation FAS IL1A 9187937 437071 However , coincubation with NG-monomethyl-L-arginine , an inhibitor of nitric oxide ( NO ) synthesis , inhibited the upregulation of [Fas] *induced* by and TNF-alpha . Positive_regulation FAS IL1A 9690559 523061 Functional studies revealed that *stimulated* RTC [Fas] expression was accompanied by increased apoptosis , which was inhibited by blocking anti-Fas ligand antibodies . Positive_regulation FAS IL1A 9973455 596170 3 ) [Fas] is also expressed constitutively and is *up-regulated* by , IL-6 , or TNF-alpha in which the pretreatment of IFN-gamma triggers astrocytes to express more Fas ; Positive_regulation FAS IL1B 10626753 576263 [Fas] surface expression was *increased* , in a time dependent fashion , by the inflammatory cytokines and TNF-alpha . Positive_regulation FAS IL1B 10678925 668323 Of various inflammatory cytokines tested , only and tumor necrosis factor alpha *induced* [Fas] Ag expression , and removal of either of these from the conditioned medium abrogated the response . Positive_regulation FAS IL1B 10924745 718409 Flow cytometric analyses demonstrated that TGF-beta1 , , and EGF did not *induce* [Fas] expression on the cell surface . Positive_regulation FAS IL1B 11473033 841556 Inactivation of two adjacent NF-kappaB and C/EBP sites in this region abolished *induced* [Fas] promoter activity in RINm5F cells . Positive_regulation FAS IL1B 12365794 995283 in intra-islet macrophages may *induce* [Fas] and inducible nitric oxide synthase expression in an autocrine and paracrine manner and mediate beta cell destruction or even death of some macrophages and T cells . Positive_regulation FAS IL1B 15033908 1244020 The effect of FasL on NIT-1 cells was evident during and after the *induction* of [Fas] expression by and IFNgamma . Positive_regulation FAS IL1B 15739117 1383027 consistently *increased* islet NFkappaB activity and c-Myc , haeme-oxygenase 1 , inducible nitric oxide synthase (iNOS) , [Fas] , and inhibitor of NFkappaB alpha ( IkappaBalpha ) mRNA levels . Positive_regulation FAS IL1B 16691186 1570035 High glucose concentrations *induce* production in human beta-cells , [Fas] expression and concomitant apoptosis owing to a constitutive expression of FasL . Positive_regulation FAS IL1B 17003335 1618370 In contrast , [Fas] *induction* by was monophasic . Positive_regulation FAS IL1B 17199973 1663131 and IL-10 *had* no significant effect on the basal [Fas] mRNA expressions in both GES-1 and AGS cells ( all P > 0.05 ) . Positive_regulation FAS IL1B 18777493 1962937 *Induction* of [Fas] by coupled with activation by Super-FasL augmented cytokine induced cell death . Positive_regulation FAS IL1B 19002429 2022191 *induced* chemokine and [Fas] expression are inhibited by suppressor of cytokine signalling-3 in insulin producing cells . Positive_regulation FAS IL1B 19002429 2022197 In INS-1 cells , + IFN-gamma *induced* a tenfold and eightfold increase of [Fas] mRNA expression after 6 and 24 h , respectively . Positive_regulation FAS IL1B 20541824 2301945 The expression of iNOS and the promoting apoptosis gene Bax and [Fas] were significantly *up-regulated* by the induction of and TNF-alpha . Positive_regulation FAS IL1B 9020075 412231 Exposure to IL-1beta induced thyrocyte apoptosis , which was prevented by antibodies that block Fas , suggesting that *induced* [Fas] expression serves as a limiting factor for thyrocyte destruction . Positive_regulation FAS IL1B 9334358 457885 NG-monomethyl-L-arginine , an inhibitor of nitric oxide (NO) synthase , prevents *induced* [Fas] expression , whereas the NO donors sodium nitroprusside and nitric oxide releasing compound ( NOC ) -18 , induce functional Fas expression in normal pancreatic beta cells . Positive_regulation FAS IL1B 9351390 461135 In culture , stimulation with interferon-gamma , tumor necrosis factor-alpha , and *increased* expression of [Fas] in SMCs . Positive_regulation FAS IL1B 9396343 468791 [Fas] expression was *induced* by stimulation . Positive_regulation FAS IL2 10372730 622067 When isolated peripheral blood lymphocytes were *induced* to express [Fas] with phytohemagglutinin ( PHA ) and and then cocultured with trophoblast , 30 % of the lymphocytes underwent apoptosis , as determined by the in situ death ( TUNEL ) assay . Positive_regulation FAS IL2 10576768 569496 However , in contrast to results of recent in vitro studies , in the BB/W rat [Fas/FasL] expression is not *regulated* by , -4 , -6 , -10 , -12 , interferon gamma , and tumor necrosis factor alpha . Positive_regulation FAS IL2 10697557 579158 In live cells from 2 CLL specimens , *caused* up-regulation of [CD95] and was associated with ex vivo drug resistance . Positive_regulation FAS IL2 11877485 919105 In contrast , CD4 ( + ) CD1d restricted NKT cells potently produced both Th1 and Th2 cytokines , up-regulated perforin in *response* to stimulation by phorbol myristate acetate and ionomycin but not or IL-12 , and could be induced to express [CD95L] . Positive_regulation FAS IL2 12816983 1103513 The increased susceptibility of RTE and naive CD4 ( + ) T cells to Fas induced apoptosis correlates with a significantly higher *induced* [Fas] expression on these T cell subsets than on memory CD4 ( + ) T cells . Positive_regulation FAS IL2 17585452 1034507 In parallel , *up-regulated* [Fas] receptor expression on HT-29 and CaCo2 cells at both protein and mRNA levels ( P < 0.05 ) , which were low before treatment , while high expression of FasR on SW480 cells remained unchanged . Positive_regulation FAS IL2 8932996 398073 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL2 9199873 438997 Cytokines further *increased* the [Fas] expression in the CD56+CD3- NK cells , with being the most potent stimulus followed by IL-12 , while IL-7 had no effect . Positive_regulation FAS IL2 9199873 439000 and IL-7 equally *enhanced* the [Fas] expression in the CD56+CD3+ population , while IL-12 had a less pronounced effect . Positive_regulation FAS IL2 9823934 549026 About 30 % of unstimulated PBLs expressed [Fas] , and the expression was *augmented* by interleukin-1beta (IL-1beta) , , tumor necrosis factor-alpha (TNF-alpha) , interferon-gamma (IFN-gamma) , or PMA plus ionomycin . Positive_regulation FAS IL20 8932996 398074 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL21 8932996 398075 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL22 8932996 398058 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL24 15833826 1394538 Promoter based reporter gene analyses showed that specifically *activated* the [Fas] promoter . Positive_regulation FAS IL24 19417161 2179803 *caused* plasma membrane clustering of CD95 and the association of [CD95] with procaspase-8 . Positive_regulation FAS IL24 19417161 2179819 Our data show that in kidney cancer cells *induces* ceramide dependent activation of [CD95] , which is causal in promoting an endoplasmic reticulum stress response that activates multiple proapoptotic pathways to decrease survival . Positive_regulation FAS IL24 8932996 398056 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL25 8932996 398057 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL26 8932996 398062 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL27 8932996 398063 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL3 8932996 398076 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL3 9694505 523718 Hematopoietic cytokines ( stem cell factor , , granulocyte macrophage colony stimulating factor [ GM-CSF ] , and granulocyte-colony stimulating factor [ G-CSF ] *contribute* to upregulation of [CD95] on bone marrow cells . Positive_regulation FAS IL31 8932996 398064 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL32 21321117 2410760 *induced* [Fas] and ULBP2 expression are regulated p38 MAPK . Positive_regulation FAS IL32 8932996 398061 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL33 8932996 398060 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL34 8932996 398065 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL37 8932996 398059 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL4 8932996 398077 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL4 9045916 416664 In contrast to B-2 cells , B-1 cells expressed [Fas] at only low levels in *response* to CD40L-CD8alpha alone or CD40L-CD8alpha + , and were resistant to Fas mediated apoptosis following these treatments . Positive_regulation FAS IL4 9847443 557698 did not *enhance* eosinophil surface expression of [APO-1/Fas] antigen ( CD95 ) . Positive_regulation FAS IL5 8932996 398078 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL6 21479379 2009694 SOCS1 silencing in DCs could prevent immune tolerance by inhibiting [Fas] and Fas-L expression , *induced* by an increase in IL-12p70 and production . Positive_regulation FAS IL6 8932996 398079 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL6 9973455 596171 3 ) [Fas] is also expressed constitutively and is *up-regulated* by IL-1 , , or TNF-alpha in which the pretreatment of IFN-gamma triggers astrocytes to express more Fas ; Positive_regulation FAS IL7 12816983 1103514 The increased susceptibility of RTE and naive CD4 ( + ) T cells to Fas induced apoptosis correlates with a significantly higher *induced* [Fas] expression on these T cell subsets than on memory CD4 ( + ) T cells . Positive_regulation FAS IL7 15720434 1374386 We demonstrate that *mediated* the up-regulation of CD25 , [CD95] and human leucocyte antigen-DR , while it did not alter the expression of CD45RO , CD69 , CD40 , or CD154 . Positive_regulation FAS IL7 17404319 1722055 *induced* the association of [Fas] with the cytoskeletal component ezrin and a polarized Fas expression on the cell surface . Positive_regulation FAS IL7 17404319 1722058 The potential *role* of in [Fas] up-regulation in vivo was verified in IL-7 treated macaques and in HIV infected or chemotherapy treated patients by the correlation between serum IL-7 levels and Fas expression on T cells . Positive_regulation FAS IL7 8932996 398080 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL7 9199873 439001 IL-2 and equally *enhanced* the [Fas] expression in the CD56+CD3+ population , while IL-12 had a less pronounced effect . Positive_regulation FAS IL8 11595074 870103 IFN-gamma pretreatment and [Fas] Ag stimulation synergistically *induced* not only apoptosis but also and MCP-1 secretion . Positive_regulation FAS IL8 12395092 1008598 It was previously shown that astrocytes are resistant to Fas mediated death , responding to [Fas] *triggering* by production . Positive_regulation FAS IL8 17199973 1663134 *up-regulated* the basal [Fas] mRNA expression level of the GES-1 cells by 33.0 % ( P < 0.05 ) . Positive_regulation FAS IL8 8932996 398081 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS IL9 8932996 398082 Mouse islet cell lysis mediated by *induced* [Fas] . Positive_regulation FAS ILK 21071740 2401814 Cell spreading in differentiated HTM cells required ILK , since ILK siRNA and the inhibitors significantly *reduced* cell spreading , actin polymerization , and the localization of talin and ILK in [focal adhesions (FAs)] . Positive_regulation FAS ING3 16520380 1549365 In addition , *up-regulated* [Fas] expression at both mRNA and protein levels . Positive_regulation FAS INGX 15748897 1379419 In addition , we showed that under non-stress conditions *upregulates* [Fas] expression and activates caspase 8 . Positive_regulation FAS INS 11015611 737586 Agouti and independently and additively *increase* [FAS] activity in 3T3-L1 adipocytes . Positive_regulation FAS INS 11015611 737587 We further investigated the mechanism responsible for the agouti induced FAS expression in these cells and demonstrated that both ( 3-fold increase ) and agouti ( 2-fold ) *increased* [FAS] gene expression at the transcriptional level . Positive_regulation FAS INS 11533263 854663 The purpose of the current study was to examine the *role* of in this exercise down-regulation of [FAS] . Positive_regulation FAS INS 11782483 916673 Thus , SREBP-2 and/or SREBP-1a can substitute partially for SREBP-1c in permitting an mediated *increase* in ACC and [FAS] mRNAs . Positive_regulation FAS INS 11855808 914049 Taken together , our data suggest that does not *stimulate* [FAS] gene expression through increasing SREBP-1c transcription in adipose cells . Positive_regulation FAS INS 11919653 926060 Higher concentrations of troglitazone ( > or =1 microM ) inhibited both *stimulated* PKB activity and expression of [FAS] . Positive_regulation FAS INS 11919653 926062 In summary , our data indicate a dual effect of troglitazone on the *induced* [FAS] gene expression in 3T3-L1 cells . Positive_regulation FAS INS 12538620 1050179 However , further *increased* [FAS] mRNA expression in C/EBPalpha-IGF-IR ( -/- ) cells , but not in PPARgamma-IGF-IR ( -/- ) cells . Positive_regulation FAS INS 1356982 198181 ( 100 nM ) added in the presence of lactate and pyruvate did not *stimulate* the expression of [FAS] and ACC . Positive_regulation FAS INS 15543204 1360719 [FAS] expression is *stimulated* by and glucose , and insulin is also the primary trigger of hepatocarcinogenesis in an endocrine experimental model , which is induced by low-number transplantation of islets of Langerhans into the livers of diabetic rats . Positive_regulation FAS INS 16800817 1612718 The transcriptional response is mediated by and increased glucose oxidation , and both signals are *necessary* for optimal induction of [FAS] ( fatty acid synthase ) . Positive_regulation FAS INS 18682535 1973397 We show that both T ( 3 ) and *regulate* [FAS] transcription via this sequence . Positive_regulation FAS INS 19411549 2075265 Compared with the control group , 100 and 150 nmol l ( -1 ) *increased* TG accumulation , acetyl-CoA carboxylase-alpha (ACCalpha) and fatty acid synthase (FAS) activity , and the mRNA levels of sterol regulatory element binding protein-1 ( SREBP-1 ) , [FAS] and ACCalpha genes . Positive_regulation FAS INS 19411549 2075269 at 200 nmol l ( -1 ) had an inhibiting effect on TG accumulation and the activity of ACC and FAS , but *increased* the gene expression of SREBP-1 , [FAS] and ACCalpha . Positive_regulation FAS INS 19843871 2299414 These data demonstrate that [FAs] differently regulate amylin and insulin expression and *induce* both amylin and release . Positive_regulation FAS INS 21098489 2377284 *induced* [FAS] in endothelial cells freshly isolated from humans , and eNOS palmitoylation was decreased in mice with insulin-deficient or insulin-resistant diabetes . Positive_regulation FAS INS 21447637 2432383 Knockdown of either the IRE1a or XBP1 gene by small interfering RNA prevented the *stimulated* promoter activities of both SREBP-1 and [FAS] genes . Positive_regulation FAS INS 22722903 2740120 *Upregulation* of SREBP1 and [FAS] expression by rescued these cells from oridonin induced apoptosis . Positive_regulation FAS INS 2535847 105757 This indicates that ongoing protein synthesis is necessary for the transcriptional *activation* of the [FAS] gene by . Positive_regulation FAS INS 7905448 245797 The fall in plasma glucagon after weaning to a high-carbohydrate diet could reinforce the *induced* accumulation of [FAS] and ACC mRNA , as this hormone inhibits the accumulation of lipogenic enzyme mRNA in liver and white adipose tissue . Positive_regulation FAS INS 8119899 250639 This *stimulation* of the [FAS] promoter activity by was dose dependent . Positive_regulation FAS INS 8869748 389337 In adipose tissue , *increases* indirectly the expression of [FAS] and ACC by stimulating glucose metabolism through its well-known effect on glucose transport . Positive_regulation FAS INS 8912704 395438 Moreover , both IGF-I and *increased* the [FAS] gene transcription rate at 2 h , producing a time dependent accumulation of FAS mRNA . Positive_regulation FAS INS 9644037 514523 Furthermore , we demonstrated that the *induction* of human [FAS] expression by was due to increased transcription rate of the FAS gene in human adipocytes , whereas mRNA stabilization accounted for increased FAS mRNA content in hepatoma cells . Positive_regulation FAS INS 9706228 526268 *stimulates* transcription of the [FAS] and mitochondrial GPAT genes , and glucagon antagonizes the insulin effect through the cis acting elements within the promoters and their bound trans acting factors . Positive_regulation FAS INS 9738010 531723 The [FAS] promoter was *up-regulated* by through the proximal insulin response sequence containing an E-box motif at the -65-base pair position . Positive_regulation FAS INS 9738010 531725 PD98059 and rapamycin , which inhibit MAP kinase and P70 S6 kinase , respectively , had little effect on the *stimulated* [FAS] promoter activity in 3T3-L1 adipocytes . Positive_regulation FAS INS 9738010 531726 On the other hand , wortmannin and LY294002 , which specifically inactivate PI 3-kinase , strongly inhibited the *stimulated* [FAS] promoter activity . Positive_regulation FAS IRF1 11801659 902584 Ectopic expression *induces* [CD95L] promoter activity . Positive_regulation FAS IRS1 12763374 1093900 Constitutive over-expression of the *causes* functional up-regulation of [Fas] receptor . Positive_regulation FAS ISL1 16517140 1611810 Western blot analysis revealed that *increased* the levels of membrane bound Fas ligand (FasL) , [Fas] , cleaved casapse-8 , truncated Bid ( tBid ) , Bax and Bad in DU145 cells ( P < .05 ) . Positive_regulation FAS ISL2 16517140 1611809 Western blot analysis revealed that *increased* the levels of membrane bound Fas ligand (FasL) , [Fas] , cleaved casapse-8 , truncated Bid ( tBid ) , Bax and Bad in DU145 cells ( P < .05 ) . Positive_regulation FAS ITGAL 10321958 612427 We also showed that [Fas] lytic activity was unaltered and that the loss of granule mediated cytotoxicity was not *due* to reduced expression or to a decrease in target cell ( TC ) binding . Positive_regulation FAS ITIH4 9263011 449156 By contrast , CD4 association with [CD95] was *induced* only by ( 451 ) and gp120MN ; Positive_regulation FAS JAZF1 24583129 2924895 The overexpression of inhibited lipid accumulation in differentiated mature 3T3-L1 adipocytes and significantly *inhibited* the expression of SREBPl , ACC , and [FAS] , which were important in lipid synthesis , while upregulating the expression of key enzyme hormone-sensitive lipase in lipoclasis . Positive_regulation FAS JUN 10391681 626709 [Fas] ligation in the presence of cycloheximide *induced* and JNK2 phosphorylation , caspase activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation FAS JUN 10602493 574841 *Activation* of by [Fas] ligation is caspase dependent , suggesting that caspases may regulate activators of the JNK pathway . Positive_regulation FAS JUN 10811113 692989 Nitric oxide inhibits apoptosis via *dependent* [CD95L] transactivation . Positive_regulation FAS JUN 10811113 692990 The induction of the CD95/CD95L pathway can be activated by the *mediated* up-regulation of the [CD95L] promoter , which is responsible for the induction of apoptosis elicited by stimuli such as etoposide . Positive_regulation FAS JUN 10811113 692993 ( c ) *transactivation* of the [CD95L] promoter ; Positive_regulation FAS JUN 10811113 692994 In conclusion , our data demonstrate that NO can modulate cell death at an upstream level , by interfering with the ability of to *induce* [CD95L] expression . Positive_regulation FAS JUN 11400169 824376 Cross linking of CD95 enhanced AP-1 DNA binding activity and dependent [CD95L] *transactivation* , which were both significantly reduced by different NO-donors compounds . Positive_regulation FAS JUN 11463377 843410 The expression of dominant negative Stat3 or in melanoma cells efficiently *increased* [Fas] expression and sensitized cells to FasL induced apoptosis . Positive_regulation FAS JUN 12681512 1077496 AP20187 mediated [Fas] dimerization *induced* not only apoptosis but also activation . Positive_regulation FAS JUN 17208988 1732437 Ten days post-MI , apoptosis among granulation tissue cells was significantly suppressed in the olmesartan treated hearts , where expression of [Fas] , Bax , procaspase-3 , and Daxx and *activation* of caspase-3 , c-Jun NH ( 2 ) -terminal kinase , and were all significantly attenuated . Positive_regulation FAS JUN 8562955 349056 [Fas] ligation *induces* apoptosis and kinase activation independently of CD45 and Lck in human T cells . Positive_regulation FAS KITLG 15919153 1420430 *enhanced* [Fas] expression in NT2/D1 cells and prevented the decrease of Fas expression when RA was also added . Positive_regulation FAS KRR1 19641134 2124587 In this study , we show that in Jurkat T lymphocytes , is also *necessary* for the most efficient activation of downstream caspases by [Fas] when treated with membrane bound Fas ligand , but not with agonistic Abs or cross linked soluble Fas ligand . Positive_regulation FAS LCK 15016553 1220926 Finally , the apoptotic effect of Tip in T cells is mediated by [Fas] and *requires* the presence of active in the cell . Positive_regulation FAS LCK 8562955 349060 Our data suggest that although CD45 and are not *required* for [Fas] signaling , JNK activation may play an important role transducing distal signals that lead to apoptosis after Fas ligation . Positive_regulation FAS LCK 9257838 448530 Together , these data indicate that TCR induced apoptosis in BI-141 is regulated through a mechanism ( s ) distinct from the *induced* expression of [Fas] , FasL , or IL-2 production . Positive_regulation FAS LEO1 12709415 1093349 The activated increased the mucosal IL-6 and PECAM-1 , *enhanced* the expression of FasL but not [Fas] , and led to the cleavage of Bid and the release of cytochrome c from mitochondria to activate caspase-9 . Positive_regulation FAS LEP 15941644 1458640 Despite the decrease of food intake , significantly *induced* the expression of [FAS] in chicken liver . Positive_regulation FAS LEP 18949391 1978902 enhanced anti-Fas IgM mediated growth inhibition and DNA fragmentation , but did not *enhance* the expression of either [Fas] antigen or Fas ligand . Positive_regulation FAS LEP 21773585 2456816 These findings suggest that the regulation of secretion by APE may *inhibit* [FAS] activity with subsequent suppression of triglyceride accumulation in the liver and adipose tissues . Positive_regulation FAS LPA 15661236 1365062 Our studies suggest that *induces* translocation of [Fas] from the cell membrane to the cytosol , which may provide a mechanism by which ovarian cancer cells evade FasL bearing immune cells . Positive_regulation FAS LPA 21602495 2441761 The results indicate that prominent brain endothelial cell apoptosis occurs during relapsing remitting bacteremia in the absence of IL-10 and point to a prominent role for bacterial mediated *activation* of [FAS] and caspase-3 in this process . Positive_regulation FAS LPXN 20543562 2360315 Therefore , dynamic tyrosine phosphorylation *requires* translocation to [FAs] . Positive_regulation FAS LRRC59 8840958 386872 Specific tetrapeptide inhibitors of ICE ( Acetyl-Tyr-Val-Ala-Asp-chloromethylketone ) or CPP32beta ( Acetyl-Asp-Glu-Val-Asp-aldehyde ) prevented the [anti-Fas] antibody mediated *activation* of and inhibited apoptosis . Positive_regulation FAS LTB 20126469 2207234 Collectively , HBxDelta127 promotes cell growth through a positive feedback loop involving 5-LOX and FAS , in which released is *involved* in the up-regulation of [FAS] . Positive_regulation FAS LTF 15192017 1295270 *enhances* [Fas] expression and apoptosis in the colon mucosa of azoxymethane treated rats . Positive_regulation FAS LUM 15623759 1358495 The present study was undertaken to investigate the *role* of in regulating [Fas] and its impact on inflammation and healing of corneal injuries . Positive_regulation FAS MAP2K1 12207331 983602 Further analysis with A3.01 T cells revealed that the proinflammatory signaling activity of [CD95] was *mediated* by , p38 and NF-kappaB signaling pathways . Positive_regulation FAS MAP2K2 12207331 983603 Further analysis with A3.01 T cells revealed that the proinflammatory signaling activity of [CD95] was *mediated* by , p38 and NF-kappaB signaling pathways . Positive_regulation FAS MAP2K3 12207331 983604 Further analysis with A3.01 T cells revealed that the proinflammatory signaling activity of [CD95] was *mediated* by , p38 and NF-kappaB signaling pathways . Positive_regulation FAS MAP2K4 12207331 983605 Further analysis with A3.01 T cells revealed that the proinflammatory signaling activity of [CD95] was *mediated* by , p38 and NF-kappaB signaling pathways . Positive_regulation FAS MAP2K5 12207331 983606 Further analysis with A3.01 T cells revealed that the proinflammatory signaling activity of [CD95] was *mediated* by , p38 and NF-kappaB signaling pathways . Positive_regulation FAS MAP2K6 12207331 983607 Further analysis with A3.01 T cells revealed that the proinflammatory signaling activity of [CD95] was *mediated* by , p38 and NF-kappaB signaling pathways . Positive_regulation FAS MAP2K7 12207331 983608 Further analysis with A3.01 T cells revealed that the proinflammatory signaling activity of [CD95] was *mediated* by , p38 and NF-kappaB signaling pathways . Positive_regulation FAS MAP2K7 22509080 2584043 Compared with HepG2 cell group and RNAi group , apoptosis rate , the expression of [Fas] and FasL proteins , and the *activation* of MLK3 , and JNKs were increased in the pcDNA3.1-X transfected group . Positive_regulation FAS MAP3K5 11193028 761659 [Fas] also activates a caspase independent pathway which correlates with Fas induced translocation of Daxx from the nucleus to the cytoplasm and *involves* the interaction of Daxx with Fas and . Positive_regulation FAS MAP3K5 11495919 868123 In addition , Daxx was bound to the activated [Fas] only in the *presence* of , accelerating the Fas mediated apoptosis . Positive_regulation FAS MAPK1 17900305 1824076 Inhibitors of p38 *prevented* augmentation of [Fas] expression in IFN-gamma and LPS treated END-D cells . Positive_regulation FAS MAPK1 19009558 2016529 Activated ERK was found to attenuate p38 *mediated* upregulation of [Fas] and FasL . Positive_regulation FAS MAPK1 22505709 2607744 Inhibition of and NF-?B activity by SB203580 and/or CAPE *reduced* [Fas] expression and apoptosis in salivary epithelial cells , establishing p38MAPK and NF-?B as proapoptotic factors in this context . Positive_regulation FAS MAPK1 8978296 408919 Because interleukin-6 (IL-6) is a growth factor for MM cells and inhibits apoptosis induced by dexamethasone and serum starvation , we examined whether IL-6 affects [anti-Fas] MoAb induced apoptosis and *activation* of SAPK or p38 in MM cells . Positive_regulation FAS MAPK10 17900305 1824077 Inhibitors of p38 *prevented* augmentation of [Fas] expression in IFN-gamma and LPS treated END-D cells . Positive_regulation FAS MAPK10 19009558 2016530 Activated ERK was found to attenuate p38 *mediated* upregulation of [Fas] and FasL . Positive_regulation FAS MAPK10 22505709 2607745 Inhibition of and NF-?B activity by SB203580 and/or CAPE *reduced* [Fas] expression and apoptosis in salivary epithelial cells , establishing p38MAPK and NF-?B as proapoptotic factors in this context . Positive_regulation FAS MAPK10 8978296 408920 Because interleukin-6 (IL-6) is a growth factor for MM cells and inhibits apoptosis induced by dexamethasone and serum starvation , we examined whether IL-6 affects [anti-Fas] MoAb induced apoptosis and *activation* of SAPK or p38 in MM cells . Positive_regulation FAS MAPK11 17900305 1824078 Inhibitors of p38 *prevented* augmentation of [Fas] expression in IFN-gamma and LPS treated END-D cells . Positive_regulation FAS MAPK11 19009558 2016531 Activated ERK was found to attenuate p38 *mediated* upregulation of [Fas] and FasL . Positive_regulation FAS MAPK11 22505709 2607746 Inhibition of and NF-?B activity by SB203580 and/or CAPE *reduced* [Fas] expression and apoptosis in salivary epithelial cells , establishing p38MAPK and NF-?B as proapoptotic factors in this context . Positive_regulation FAS MAPK11 8978296 408921 Because interleukin-6 (IL-6) is a growth factor for MM cells and inhibits apoptosis induced by dexamethasone and serum starvation , we examined whether IL-6 affects [anti-Fas] MoAb induced apoptosis and *activation* of SAPK or p38 in MM cells . Positive_regulation FAS MAPK12 17900305 1824079 Inhibitors of p38 *prevented* augmentation of [Fas] expression in IFN-gamma and LPS treated END-D cells . Positive_regulation FAS MAPK12 19009558 2016532 Activated ERK was found to attenuate p38 *mediated* upregulation of [Fas] and FasL . Positive_regulation FAS MAPK12 22505709 2607747 Inhibition of and NF-?B activity by SB203580 and/or CAPE *reduced* [Fas] expression and apoptosis in salivary epithelial cells , establishing p38MAPK and NF-?B as proapoptotic factors in this context . Positive_regulation FAS MAPK12 8978296 408922 Because interleukin-6 (IL-6) is a growth factor for MM cells and inhibits apoptosis induced by dexamethasone and serum starvation , we examined whether IL-6 affects [anti-Fas] MoAb induced apoptosis and *activation* of SAPK or p38 in MM cells . Positive_regulation FAS MAPK13 17900305 1824080 Inhibitors of p38 *prevented* augmentation of [Fas] expression in IFN-gamma and LPS treated END-D cells . Positive_regulation FAS MAPK13 19009558 2016533 Activated ERK was found to attenuate p38 *mediated* upregulation of [Fas] and FasL . Positive_regulation FAS MAPK13 22505709 2607748 Inhibition of and NF-?B activity by SB203580 and/or CAPE *reduced* [Fas] expression and apoptosis in salivary epithelial cells , establishing p38MAPK and NF-?B as proapoptotic factors in this context . Positive_regulation FAS MAPK13 8978296 408923 Because interleukin-6 (IL-6) is a growth factor for MM cells and inhibits apoptosis induced by dexamethasone and serum starvation , we examined whether IL-6 affects [anti-Fas] MoAb induced apoptosis and *activation* of SAPK or p38 in MM cells . Positive_regulation FAS MAPK14 17900305 1824081 Inhibitors of p38 *prevented* augmentation of [Fas] expression in IFN-gamma and LPS treated END-D cells . Positive_regulation FAS MAPK14 19009558 2016534 Activated ERK was found to attenuate p38 *mediated* upregulation of [Fas] and FasL . Positive_regulation FAS MAPK14 22505709 2607749 Inhibition of and NF-?B activity by SB203580 and/or CAPE *reduced* [Fas] expression and apoptosis in salivary epithelial cells , establishing p38MAPK and NF-?B as proapoptotic factors in this context . Positive_regulation FAS MAPK14 8978296 408924 Because interleukin-6 (IL-6) is a growth factor for MM cells and inhibits apoptosis induced by dexamethasone and serum starvation , we examined whether IL-6 affects [anti-Fas] MoAb induced apoptosis and *activation* of SAPK or p38 in MM cells . Positive_regulation FAS MAPK15 17900305 1824075 Inhibitors of p38 *prevented* augmentation of [Fas] expression in IFN-gamma and LPS treated END-D cells . Positive_regulation FAS MAPK15 19009558 2016527 Activated ERK was found to attenuate p38 *mediated* upregulation of [Fas] and FasL . Positive_regulation FAS MAPK15 22505709 2607742 Inhibition of and NF-?B activity by SB203580 and/or CAPE *reduced* [Fas] expression and apoptosis in salivary epithelial cells , establishing p38MAPK and NF-?B as proapoptotic factors in this context . Positive_regulation FAS MAPK15 8978296 408918 Because interleukin-6 (IL-6) is a growth factor for MM cells and inhibits apoptosis induced by dexamethasone and serum starvation , we examined whether IL-6 affects [anti-Fas] MoAb induced apoptosis and *activation* of SAPK or p38 in MM cells . Positive_regulation FAS MAPK3 17900305 1824082 Inhibitors of p38 *prevented* augmentation of [Fas] expression in IFN-gamma and LPS treated END-D cells . Positive_regulation FAS MAPK3 19009558 2016535 Activated ERK was found to attenuate p38 *mediated* upregulation of [Fas] and FasL . Positive_regulation FAS MAPK3 22505709 2607750 Inhibition of and NF-?B activity by SB203580 and/or CAPE *reduced* [Fas] expression and apoptosis in salivary epithelial cells , establishing p38MAPK and NF-?B as proapoptotic factors in this context . Positive_regulation FAS MAPK3 8978296 408925 Because interleukin-6 (IL-6) is a growth factor for MM cells and inhibits apoptosis induced by dexamethasone and serum starvation , we examined whether IL-6 affects [anti-Fas] MoAb induced apoptosis and *activation* of SAPK or p38 in MM cells . Positive_regulation FAS MAPK4 17900305 1824083 Inhibitors of p38 *prevented* augmentation of [Fas] expression in IFN-gamma and LPS treated END-D cells . Positive_regulation FAS MAPK4 19009558 2016536 Activated ERK was found to attenuate p38 *mediated* upregulation of [Fas] and FasL . Positive_regulation FAS MAPK4 22505709 2607751 Inhibition of and NF-?B activity by SB203580 and/or CAPE *reduced* [Fas] expression and apoptosis in salivary epithelial cells , establishing p38MAPK and NF-?B as proapoptotic factors in this context . Positive_regulation FAS MAPK4 8978296 408926 Because interleukin-6 (IL-6) is a growth factor for MM cells and inhibits apoptosis induced by dexamethasone and serum starvation , we examined whether IL-6 affects [anti-Fas] MoAb induced apoptosis and *activation* of SAPK or p38 in MM cells . Positive_regulation FAS MAPK6 17900305 1824084 Inhibitors of p38 *prevented* augmentation of [Fas] expression in IFN-gamma and LPS treated END-D cells . Positive_regulation FAS MAPK6 19009558 2016537 Activated ERK was found to attenuate p38 *mediated* upregulation of [Fas] and FasL . Positive_regulation FAS MAPK6 22505709 2607752 Inhibition of and NF-?B activity by SB203580 and/or CAPE *reduced* [Fas] expression and apoptosis in salivary epithelial cells , establishing p38MAPK and NF-?B as proapoptotic factors in this context . Positive_regulation FAS MAPK6 8978296 408927 Because interleukin-6 (IL-6) is a growth factor for MM cells and inhibits apoptosis induced by dexamethasone and serum starvation , we examined whether IL-6 affects [anti-Fas] MoAb induced apoptosis and *activation* of SAPK or p38 in MM cells . Positive_regulation FAS MAPK7 17900305 1824085 Inhibitors of p38 *prevented* augmentation of [Fas] expression in IFN-gamma and LPS treated END-D cells . Positive_regulation FAS MAPK7 19009558 2016538 Activated ERK was found to attenuate p38 *mediated* upregulation of [Fas] and FasL . Positive_regulation FAS MAPK7 22505709 2607753 Inhibition of and NF-?B activity by SB203580 and/or CAPE *reduced* [Fas] expression and apoptosis in salivary epithelial cells , establishing p38MAPK and NF-?B as proapoptotic factors in this context . Positive_regulation FAS MAPK7 8978296 408928 Because interleukin-6 (IL-6) is a growth factor for MM cells and inhibits apoptosis induced by dexamethasone and serum starvation , we examined whether IL-6 affects [anti-Fas] MoAb induced apoptosis and *activation* of SAPK or p38 in MM cells . Positive_regulation FAS MAPK8 17900305 1824086 Inhibitors of p38 *prevented* augmentation of [Fas] expression in IFN-gamma and LPS treated END-D cells . Positive_regulation FAS MAPK8 19009558 2016539 Activated ERK was found to attenuate p38 *mediated* upregulation of [Fas] and FasL . Positive_regulation FAS MAPK8 22505709 2607754 Inhibition of and NF-?B activity by SB203580 and/or CAPE *reduced* [Fas] expression and apoptosis in salivary epithelial cells , establishing p38MAPK and NF-?B as proapoptotic factors in this context . Positive_regulation FAS MAPK8 8978296 408929 Because interleukin-6 (IL-6) is a growth factor for MM cells and inhibits apoptosis induced by dexamethasone and serum starvation , we examined whether IL-6 affects [anti-Fas] MoAb induced apoptosis and *activation* of SAPK or p38 in MM cells . Positive_regulation FAS MAPK9 10391681 626710 [Fas] ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and phosphorylation , caspase activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation FAS MAPK9 17900305 1824087 Inhibitors of p38 *prevented* augmentation of [Fas] expression in IFN-gamma and LPS treated END-D cells . Positive_regulation FAS MAPK9 19009558 2016540 Activated ERK was found to attenuate p38 *mediated* upregulation of [Fas] and FasL . Positive_regulation FAS MAPK9 22505709 2607755 Inhibition of and NF-?B activity by SB203580 and/or CAPE *reduced* [Fas] expression and apoptosis in salivary epithelial cells , establishing p38MAPK and NF-?B as proapoptotic factors in this context . Positive_regulation FAS MAPK9 8978296 408930 Because interleukin-6 (IL-6) is a growth factor for MM cells and inhibits apoptosis induced by dexamethasone and serum starvation , we examined whether IL-6 affects [anti-Fas] MoAb induced apoptosis and *activation* of SAPK or p38 in MM cells . Positive_regulation FAS MBTPS1 18209090 1857838 also *enhanced* [Fas] expression and Fas mediated caspase-3 induction in salivary gland epithelial cells . Positive_regulation FAS MBTPS1 20651091 2322113 , but not carbachol , *induces* the expression of interleukin-6 and [Fas] . Positive_regulation FAS MED1 22665482 2632807 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED10 22665482 2632802 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED11 22665482 2632805 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED13 22665482 2632789 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED13L 22665482 2632790 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED14 22665482 2632794 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED15 22665482 2632783 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED16 22665482 2632785 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED17 22665482 2632796 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED18 22665482 2632801 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED19 22665482 2632804 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED20 22665482 2632784 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED21 22665482 2632781 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED22 22665482 2632782 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED23 22665482 2632795 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED24 22665482 2632791 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED25 22665482 2632803 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED26 22665482 2632797 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED27 22665482 2632798 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED29 22665482 2632793 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED30 22665482 2632792 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED31 22665482 2632800 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED4 22665482 2632786 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED6 22665482 2632787 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED7 22665482 2632799 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MED8 22665482 2632788 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS MIC12 2270736 147340 The effect of two concentrations of methicillin on the fatty acid ( FA ) distribution in intracellular total polar lipid ( TPL ) of the log-phase cultures of a methicillin resistant Staphylococcus aureus strain No. 5814R was studied during a period of 2 h. Half the of methicillin ( = 1000 micrograms/ml ) *caused* 18.6 % increase in [branched-FAs] and a same decrease in straight-FAs , while one MIC ( = 2000 micrograms/ml ) of the drug induced a moderate change in those of TPL . Positive_regulation FAS MIC7 2270736 147341 The effect of two concentrations of methicillin on the fatty acid ( FA ) distribution in intracellular total polar lipid ( TPL ) of the log-phase cultures of a methicillin resistant Staphylococcus aureus strain No. 5814R was studied during a period of 2 h. Half the of methicillin ( = 1000 micrograms/ml ) *caused* 18.6 % increase in [branched-FAs] and a same decrease in straight-FAs , while one MIC ( = 2000 micrograms/ml ) of the drug induced a moderate change in those of TPL . Positive_regulation FAS MLXIPL 16184193 1462209 The aim of our study was to assess the *role* of in the control of L-PK and [FAS] gene expression by PUFAs . Positive_regulation FAS MPP1 7542501 314123 The TNF-alpha induced [Fas] expression is *mediated* by TNF-alpha receptor . Positive_regulation FAS MSN 14676203 1211109 We have previously shown that was not *involved* in the binding to [CD95] . Positive_regulation FAS MSN 18941185 1978104 Ezrin and moesin have to be present together for the formation of Fas aggregates since down-regulation of either ezrin or expression with small interfering RNAs completely *inhibits* [Fas] aggregate formation . Positive_regulation FAS MTOR 23585690 2794899 Rapamycin induced inhibition of complex 1 ( mTORC1 ) , a mediator of the feeding/insulin signal to induce lipogenesis , *reduced* [FAS] phosphorylation , increased cytoplasmic FAS enzyme activity , and increased PPARa target gene expression . Positive_regulation FAS MTX1 9811059 545560 alone and in combination with 1,25-OH-CCF markedly stimulated the differentiation of the monocytic U937 cells and simultaneously *increased* [Fas-antigen] expression . Positive_regulation FAS MYC 12851485 1109616 also *activates* the [CD95/Fas-FADD] mediated death signal . Positive_regulation FAS MYLIP 21693609 2460486 Forced overexpression of miR-23a decreased H ( 2 ) O ( 2 ) or tBH induced [Fas] upregulation , and this effect was *blocked* by downregulation of . Positive_regulation FAS MYLIP 22186140 2549487 Overexpression of consistently *resulted* in the downregulation of [Fas] expression in SAOS-2 cells and thus in decreased sensitivity to FasL . Positive_regulation FAS MYLIP 23645835 2795898 These results indicate that may be *involved* in the pathogenesis of ALPS by targeting [Fas] and may therefore serve as a novel therapeutic target . Positive_regulation FAS MYLIP 24924176 2941941 Our investigations show that [Fas] expression in osteosarcoma cells is *regulated* epigenetically by the micro-RNA , encoded by the miR-17-92 cluster . Positive_regulation FAS NANOS3 22861189 2719708 overexpression *increased* oxidative/nitrosative stress , p53 and [CD95] expression , cellular Fas associated death domain (FADD)-like IL-1beta converting enzyme ( FLICE ) inhibitory protein long ( cFLIP ( L ) ) and its short isoform ( cFLIP ( S ) ) shift , and cell death in HepG2 ( 4TO-NOS ) cells . Positive_regulation FAS NELFCD 11877485 919102 In contrast , CD4 ( + ) CD1d restricted NKT cells potently produced both and Th2 cytokines , up-regulated perforin in response to stimulation by phorbol myristate acetate and ionomycin but not IL-2 or IL-12 , and could be *induced* to express [CD95L] . Positive_regulation FAS NFKB1 10022897 590537 Activation dependent transcriptional regulation of the human [Fas] promoter *requires* p50-p65 recruitment . Positive_regulation FAS NFKB1 10092091 600395 *regulates* [Fas/APO-1/CD95-] and TCR- mediated apoptosis of T lymphocytes . Positive_regulation FAS NFKB1 10640741 660632 STAT-1alpha and activation are *involved* in IFN-gamma- or TNF-alpha mediated [Fas] up-regulation in microglia , respectively . Positive_regulation FAS NFKB1 10671224 666700 T cell activation induced and HIV tat enhanced [CD95] ( APO-1/Fas ) ligand transcription *involves* . Positive_regulation FAS NFKB1 11464292 839429 Inhibition of protein kinase C by Gö6983 sensitized these cells to apoptotic challenges and strongly diminished *activation* of by [anti-CD95] and TRAIL . Positive_regulation FAS NFKB1 12244143 990500 Fas resistance of leukemic eosinophils is due to *activation* of by [Fas] ligation . Positive_regulation FAS NFKB1 12244143 990506 Although *activation* of by ligation of [Fas] ( CD95/Apo-1 ) , a member of the TNFR family , has been observed in a few studies , Fas mediated NF-kappaB activation has not previously been shown to protect cells from apoptosis . Positive_regulation FAS NFKB1 12883671 1116466 [Fas] stimulation *induced* activation in a dose dependent manner in SK-Hep1 and HepG2 cell lines , but not in HLE cells . Positive_regulation FAS NFKB1 14625298 1200945 Caffeic acid phenethyl ester induces apoptosis by inhibition of and *activation* of [Fas] in human breast cancer MCF-7 cells . Positive_regulation FAS NFKB1 14693245 1194879 Our results suggest that activated at early stages in the okadaic acid treated SCC-25 cells *stimulated* the promoter activity of [Fas] receptor in the cells leading to the apoptotic death of these cells . Positive_regulation FAS NFKB1 15143063 1267520 *dependent* induction of tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) and [Fas/FasL] is crucial for efficient influenza virus propagation . Positive_regulation FAS NFKB1 15302589 1283975 Synergistic *induction* of the [Fas] ( CD95) ligand promoter by Max and in human non-small lung cancer cells . Positive_regulation FAS NFKB1 15382040 1298801 Arsenic trioxide sensitizes CD95/Fas induced apoptosis through ROS mediated *upregulation* of [CD95/Fas] by activation . Positive_regulation FAS NFKB1 15382040 1298803 Furthermore , inhibition of by transient transfection of IkappaBalpha supersurppessor *blocked* the increase of [CD95/Fas] expression following As2O2 treatment . Positive_regulation FAS NFKB1 15382040 1298806 These findings demonstrate that sensitization of human cervical cancer cells to CD95/Fas mediated apoptosis by As2O3 can be partly due to induction of ROS and subsequent *upregulation* of [CD95/Fas] gene expression by activation . Positive_regulation FAS NFKB1 15514680 1328470 Induction of apoptosis and *activation* of by [CD95] require different signalling thresholds . Positive_regulation FAS NFKB1 16317104 1526232 Epstein-Barr virus ( EBV ) induces CD95 expression and the [CD95] gene ( FAS ) is *regulated* by , STAT1 , and/or p53 . Positive_regulation FAS NFKB1 17118453 1667831 Besides the apoptosis signaling pathway , [CD95] ligation also *induces* the activation of . Positive_regulation FAS NFKB1 17291719 1725810 Caspase mediated activation of and ERKs were *involved* in [CD95L-] and TRAIL induced up-regulation of proinflammatory genes in Colo357-BclxL cells . Positive_regulation FAS NFKB1 17786316 1790929 The inverse activities of [Fas] and FasL promoter in tumor cells are *regulated* by , which inhibits Fas expression and increases FasL expression through binding to their respective promoters . Positive_regulation FAS NFKB1 18448526 1921248 Therefore , our results are in agreement with a model where LMP1 dependent activation *induces* [Fas] overexpression and autoactivation that could overwhelm the antiapoptotic effect of NF-kappaB , revealing an ambivalent function of LMP1 in cell survival and programmed cell death . Positive_regulation FAS NFKB1 7523113 272175 Whereas transcription factor was readily activated by TNF , activation was not *induced* by triggering [APO-1/Fas] . Positive_regulation FAS NFKB1 8939996 398731 In addition , our results demonstrate that [CD95] mediated signaling *involves* activation of ( p50/RelA ) . Positive_regulation FAS NFKB1 9525905 495455 Moreover , inhibition of activity by a transdominant IkappaB mutant *attenuated* [CD95L] expression . Positive_regulation FAS NFKBIA 9733827 531117 Overexpression of a dominant form of *blocked* LMP1 mediated TRAF1 , EBI3 , [Fas] , ICAM-1 , CD40 , and LFA-3 up-regulation , indicating that NF-kappaB is an important component of LMP1 mediated gene induction from both the TRAF- and TRADD interacting sites . Positive_regulation FAS NFYA 11530940 853809 The FIRE3 mediated sterol response of the [FAS] promoter *requires* as a coactivator . Positive_regulation FAS NFYB 11530940 853810 The FIRE3 mediated sterol response of the [FAS] promoter *requires* as a coactivator . Positive_regulation FAS NFYC 11530940 853811 The FIRE3 mediated sterol response of the [FAS] promoter *requires* as a coactivator . Positive_regulation FAS NGF 18692025 1984779 dose-dependently *induced* sprouting and the expression of the NGF receptors Trk tyrosine kinase receptor (TrkA) and p75 neurotrophin receptor ( p75 ( NTR ) ) as well as [Fas] and Fas ligand . Positive_regulation FAS NOS1 14967838 1220252 Here , we report that [Fas] engagement with Fas ligand *induced* activation of Akt and upregulation of endothelial expression without induction of apoptosis . Positive_regulation FAS NOS1 15317908 1286367 Death promoting effects have been ascribed to inhibition of nuclear factor-kappaB , increase of [Fas] expression , p53 stabilization , cytokine and chemokine release , and *activation* of , p38 , and c-Jun-N-terminal kinase . Positive_regulation FAS NOS1 23646980 2810739 P2X7 induced motor neuron death was dependent on neuronal *mediated* production of peroxynitrite , p38 activation , and autocrine [FAS] signaling . Positive_regulation FAS NOS2 14967838 1220253 Here , we report that [Fas] engagement with Fas ligand *induced* activation of Akt and upregulation of endothelial expression without induction of apoptosis . Positive_regulation FAS NOS2 15317908 1286368 Death promoting effects have been ascribed to inhibition of nuclear factor-kappaB , increase of [Fas] expression , p53 stabilization , cytokine and chemokine release , and *activation* of , p38 , and c-Jun-N-terminal kinase . Positive_regulation FAS NOS2 23646980 2810740 P2X7 induced motor neuron death was dependent on neuronal *mediated* production of peroxynitrite , p38 activation , and autocrine [FAS] signaling . Positive_regulation FAS NOS3 14967838 1220254 Here , we report that [Fas] engagement with Fas ligand *induced* activation of Akt and upregulation of endothelial expression without induction of apoptosis . Positive_regulation FAS NOS3 15317908 1286369 Death promoting effects have been ascribed to inhibition of nuclear factor-kappaB , increase of [Fas] expression , p53 stabilization , cytokine and chemokine release , and *activation* of , p38 , and c-Jun-N-terminal kinase . Positive_regulation FAS NOS3 23646980 2810741 P2X7 induced motor neuron death was dependent on neuronal *mediated* production of peroxynitrite , p38 activation , and autocrine [FAS] signaling . Positive_regulation FAS OPA1 22665482 2632806 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Positive_regulation FAS OPN1MW 15964831 1434666 However , FN or may *induce* [FAs] without increased activation of Rho ( i.e. the basal level of GTP-Rho induces sufficient phospho-MLC for FA assembly under this condition ) . Positive_regulation FAS PAF1 12709415 1093347 The activated increased the mucosal IL-6 and PECAM-1 , *enhanced* the expression of FasL but not [Fas] , and led to the cleavage of Bid and the release of cytochrome c from mitochondria to activate caspase-9 . Positive_regulation FAS PCK1 2195292 136363 ( PEPCK ) activity increased after 2 weeks on a LP diet ( +35 % , day 21 ) and [fatty acid synthetase (FAS)] activity *increased* only during the first week on the diet ( +100 % , day 7 ) . Positive_regulation FAS PCK2 2195292 136364 ( PEPCK ) activity increased after 2 weeks on a LP diet ( +35 % , day 21 ) and [fatty acid synthetase (FAS)] activity *increased* only during the first week on the diet ( +100 % , day 7 ) . Positive_regulation FAS PDCD1 10722700 677196 Activation of either tumor necrosis factor receptor 1 or [Fas] *induces* a low level of in LNCaP human prostate cancer cells . Positive_regulation FAS PDCD1 1385299 200724 Binding of anti-APO-1 antibody to the [APO-1 antigen] *induces* ( apoptosis ) . Positive_regulation FAS PDCD1 9163609 432087 We studied eight myeloma cell lines for the presence of Bcl-2 , which inhibits apoptosis , of Bax , which counteracts Bcl-2 , of Bcl-x ( L ) and Bcl-x ( S ) , which act in an anti- and pro-apoptotic fashion , respectively , and of [Apo-1/Fas] , which *induces* , when activated by the Apo-1/Fas ligand or the relevant monoclonal antibody ( mab ) . Positive_regulation FAS PDCD1 9207415 440808 CD40 and [CD95] *induce* in the human myeloma cell line XG2 . Positive_regulation FAS PDCD10 10722700 677197 Activation of either tumor necrosis factor receptor 1 or [Fas] *induces* a low level of in LNCaP human prostate cancer cells . Positive_regulation FAS PDCD10 1385299 200725 Binding of anti-APO-1 antibody to the [APO-1 antigen] *induces* ( apoptosis ) . Positive_regulation FAS PDCD10 9163609 432088 We studied eight myeloma cell lines for the presence of Bcl-2 , which inhibits apoptosis , of Bax , which counteracts Bcl-2 , of Bcl-x ( L ) and Bcl-x ( S ) , which act in an anti- and pro-apoptotic fashion , respectively , and of [Apo-1/Fas] , which *induces* , when activated by the Apo-1/Fas ligand or the relevant monoclonal antibody ( mab ) . Positive_regulation FAS PDCD10 9207415 440809 CD40 and [CD95] *induce* in the human myeloma cell line XG2 . Positive_regulation FAS PDCD11 10722700 677195 Activation of either tumor necrosis factor receptor 1 or [Fas] *induces* a low level of in LNCaP human prostate cancer cells . Positive_regulation FAS PDCD11 1385299 200723 Binding of anti-APO-1 antibody to the [APO-1 antigen] *induces* ( apoptosis ) . Positive_regulation FAS PDCD11 9163609 432086 We studied eight myeloma cell lines for the presence of Bcl-2 , which inhibits apoptosis , of Bax , which counteracts Bcl-2 , of Bcl-x ( L ) and Bcl-x ( S ) , which act in an anti- and pro-apoptotic fashion , respectively , and of [Apo-1/Fas] , which *induces* , when activated by the Apo-1/Fas ligand or the relevant monoclonal antibody ( mab ) . Positive_regulation FAS PDCD11 9207415 440807 CD40 and [CD95] *induce* in the human myeloma cell line XG2 . Positive_regulation FAS PDCD2 10722700 677198 Activation of either tumor necrosis factor receptor 1 or [Fas] *induces* a low level of in LNCaP human prostate cancer cells . Positive_regulation FAS PDCD2 1385299 200726 Binding of anti-APO-1 antibody to the [APO-1 antigen] *induces* ( apoptosis ) . Positive_regulation FAS PDCD2 9163609 432089 We studied eight myeloma cell lines for the presence of Bcl-2 , which inhibits apoptosis , of Bax , which counteracts Bcl-2 , of Bcl-x ( L ) and Bcl-x ( S ) , which act in an anti- and pro-apoptotic fashion , respectively , and of [Apo-1/Fas] , which *induces* , when activated by the Apo-1/Fas ligand or the relevant monoclonal antibody ( mab ) . Positive_regulation FAS PDCD2 9207415 440810 CD40 and [CD95] *induce* in the human myeloma cell line XG2 . Positive_regulation FAS PDCD4 10722700 677199 Activation of either tumor necrosis factor receptor 1 or [Fas] *induces* a low level of in LNCaP human prostate cancer cells . Positive_regulation FAS PDCD4 1385299 200727 Binding of anti-APO-1 antibody to the [APO-1 antigen] *induces* ( apoptosis ) . Positive_regulation FAS PDCD4 9163609 432090 We studied eight myeloma cell lines for the presence of Bcl-2 , which inhibits apoptosis , of Bax , which counteracts Bcl-2 , of Bcl-x ( L ) and Bcl-x ( S ) , which act in an anti- and pro-apoptotic fashion , respectively , and of [Apo-1/Fas] , which *induces* , when activated by the Apo-1/Fas ligand or the relevant monoclonal antibody ( mab ) . Positive_regulation FAS PDCD4 9207415 440811 CD40 and [CD95] *induce* in the human myeloma cell line XG2 . Positive_regulation FAS PDCD5 10722700 677200 Activation of either tumor necrosis factor receptor 1 or [Fas] *induces* a low level of in LNCaP human prostate cancer cells . Positive_regulation FAS PDCD5 1385299 200728 Binding of anti-APO-1 antibody to the [APO-1 antigen] *induces* ( apoptosis ) . Positive_regulation FAS PDCD5 9163609 432091 We studied eight myeloma cell lines for the presence of Bcl-2 , which inhibits apoptosis , of Bax , which counteracts Bcl-2 , of Bcl-x ( L ) and Bcl-x ( S ) , which act in an anti- and pro-apoptotic fashion , respectively , and of [Apo-1/Fas] , which *induces* , when activated by the Apo-1/Fas ligand or the relevant monoclonal antibody ( mab ) . Positive_regulation FAS PDCD5 9207415 440812 CD40 and [CD95] *induce* in the human myeloma cell line XG2 . Positive_regulation FAS PDCD6 10722700 677201 Activation of either tumor necrosis factor receptor 1 or [Fas] *induces* a low level of in LNCaP human prostate cancer cells . Positive_regulation FAS PDCD6 1385299 200729 Binding of anti-APO-1 antibody to the [APO-1 antigen] *induces* ( apoptosis ) . Positive_regulation FAS PDCD6 9163609 432092 We studied eight myeloma cell lines for the presence of Bcl-2 , which inhibits apoptosis , of Bax , which counteracts Bcl-2 , of Bcl-x ( L ) and Bcl-x ( S ) , which act in an anti- and pro-apoptotic fashion , respectively , and of [Apo-1/Fas] , which *induces* , when activated by the Apo-1/Fas ligand or the relevant monoclonal antibody ( mab ) . Positive_regulation FAS PDCD6 9207415 440813 CD40 and [CD95] *induce* in the human myeloma cell line XG2 . Positive_regulation FAS PDCD7 10722700 677202 Activation of either tumor necrosis factor receptor 1 or [Fas] *induces* a low level of in LNCaP human prostate cancer cells . Positive_regulation FAS PDCD7 1385299 200730 Binding of anti-APO-1 antibody to the [APO-1 antigen] *induces* ( apoptosis ) . Positive_regulation FAS PDCD7 9163609 432093 We studied eight myeloma cell lines for the presence of Bcl-2 , which inhibits apoptosis , of Bax , which counteracts Bcl-2 , of Bcl-x ( L ) and Bcl-x ( S ) , which act in an anti- and pro-apoptotic fashion , respectively , and of [Apo-1/Fas] , which *induces* , when activated by the Apo-1/Fas ligand or the relevant monoclonal antibody ( mab ) . Positive_regulation FAS PDCD7 9207415 440814 CD40 and [CD95] *induce* in the human myeloma cell line XG2 . Positive_regulation FAS PDLIM7 18448526 1921246 *induced* [Fas] overexpression with its relocalization in lipid raft microdomains of the membrane . Positive_regulation FAS PDLIM7 18448526 1921247 Therefore , our results are in agreement with a model where dependent NF-kappaB activation *induces* [Fas] overexpression and autoactivation that could overwhelm the antiapoptotic effect of NF-kappaB , revealing an ambivalent function of LMP1 in cell survival and programmed cell death . Positive_regulation FAS PDLIM7 19664329 2119344 As a nuclear factor-kappaB (NF-kappaB) dependent molecule , [Fas] is *induced* by , and LMP1 enhances Fas mediated apoptosis , according to our finding of stimulus dependent apoptosis regulation by LMP1 . Positive_regulation FAS PHLDA1 11713273 880864 is not *essential* for [Fas/CD95] regulation and apoptosis in vivo . Positive_regulation FAS PHLDA1 11713273 880865 Although is *required* for up-regulation of [Fas] expression in T-cell hybridomas , TDAG51-/- mice expressed normal levels of Fas and had normal T-cell apoptosis . Positive_regulation FAS PHLDA1 11713273 880866 Therefore , we conclude that is not *essential* for [Fas] up-regulation and T-cell apoptosis in vivo . Positive_regulation FAS PHLDA1 8673705 369736 Subsequently , we cloned the gene TDAG51 , which restored activation induced apoptosis when transfected into the mutant cell line , and showed that expression was *required* for [Fas] expression . Positive_regulation FAS PI3 16162944 1475991 Induction of SREBP-1 , SCD-1 , and [FAS] by KGF was *inhibited* by the JNK inhibitor SP600125 and the inhibitor LY294002 but not by the ERK inhibitor PD98059 . Positive_regulation FAS PI3 17182072 1695226 The inhibitors and tyrosine kinase inhibitors of EGFR and ErbB-2 also *reduced* constitutive [FAS] expression . Positive_regulation FAS PI3 9446703 483669 Experiments using p56lck-deficient or p56lck reconstituted Jurkat clones and the tyrosine kinase inhibitor herbimycin A revealed that tyrosine phosphorylation and *activation* of by [CD95] depends on expression of Src-like tyrosine kinases , in particular p56lck . Positive_regulation FAS PI3 9468284 485772 We demonstrate a rapid and transient *activation* of by [Fas] receptor triggering or cellular treatment with synthetic C6-ceramide . Positive_regulation FAS PI3 9468284 485774 The stimulation of is *critical* for [Fas] or C6-ceramide induced programmed cell death because transfection with a transdominant inhibitory PI-3-K construct or pre-treatment with the PI-3-K inhibitor wortmannin almost completely prevented Fas or C6-ceramide mediated apoptosis . Positive_regulation FAS PIK3C3 19204002 2049786 The up-regulation of both SREBP and [FAS] by NS4B protein *required* activity . Positive_regulation FAS PIK3CA 16162944 1476002 In summary , we conclude that KGF requires both and JNK signaling pathways to induce SREBP-1 , which in turn *induces* SCD-1 and [FAS] expression in H292 cells . Positive_regulation FAS PIK3CA 16925113 1496961 [FAS] expression in HepG2 cells was strongly *inhibited* by inhibitor LY294002 and JNK inhibitor II and slightly inhibited by p38 inhibitor SB203580 and MEK inhibitor PD98059 , separately . Positive_regulation FAS PIK3R1 16162944 1476003 In summary , we conclude that KGF *requires* both and JNK signaling pathways to induce SREBP-1 , which in turn induces SCD-1 and [FAS] expression in H292 cells . Positive_regulation FAS PIK3R1 16925113 1496962 [FAS] expression in HepG2 cells was strongly *inhibited* by inhibitor LY294002 and JNK inhibitor II and slightly inhibited by p38 inhibitor SB203580 and MEK inhibitor PD98059 , separately . Positive_regulation FAS PIK3R4 19204002 2049787 The up-regulation of both SREBP and [FAS] by NS4B protein *required* activity . Positive_regulation FAS PIN1 24596388 2920520 In contrast , juglone , a potent inhibitor , significantly *enhanced* trastuzumab induced [FAS] down-regulation and cell death in BT474 cells . Positive_regulation FAS PLA2G1B 19009558 2016555 Deprivation of catalytic activity could not diminish *induced* cell death and [Fas/FasL] upregulation . Positive_regulation FAS PLA2G1B 19180563 2049257 Block of p38 MAPK by SB202190 abolished *induced* [Fas/FasL] upregulation and ERK inactivation , but not ROS generation . Positive_regulation FAS PLA2G1B 19180563 2049275 Deprivation of catalytic activity with PLA(2) blocked completely *induced* [Fas/FasL] upregulation . Positive_regulation FAS PLA2G1B 19937732 2190486 SB202190 ( p38 MAPK inhibitor ) pretreatment enhanced cytotoxic effect of PLA(2) and led to prolonged JNK activation , but failed to affect *induced* upregulation of [Fas] and FasL protein expression . Positive_regulation FAS PLA2G1B 7540278 307215 Interestingly , exposure of MCF-Fas cells to [anti-Fas] or TNF induced *activation* of , while only TNF activated NF-kappa B . Positive_regulation FAS PLA2G1B 8557994 348687 Overexpression of A20 also inhibits TNF induced activation of phospholipase A2 in a similar dose dependent manner as it inhibits TNF mediated apoptosis , whereas it does not affect the *activation* of by [anti-Fas] . Positive_regulation FAS PLD1 11007187 735382 In an attempt to correlate the existence of PC-PLC activity and *activation* of by [Fas] activation among various Fas expressing murine cell lines , we have investigated the effect of anti-Fas monoclonal antibody on PC-PLC and PLD activities in A20 , P388D1 and YAC-1 cell lines . Positive_regulation FAS PLD1 11007187 735407 These findings suggest that the activation of PC-PLC is a necessary requirement for the *activation* of by [Fas] cross linking and cell lines devoid of functional PC-PLC activity could exhibit enhanced PLD activity by exogenous addition of PC-PLC . Positive_regulation FAS PLD2 11007187 735383 In an attempt to correlate the existence of PC-PLC activity and *activation* of by [Fas] activation among various Fas expressing murine cell lines , we have investigated the effect of anti-Fas monoclonal antibody on PC-PLC and PLD activities in A20 , P388D1 and YAC-1 cell lines . Positive_regulation FAS PLD2 11007187 735408 These findings suggest that the activation of PC-PLC is a necessary requirement for the *activation* of by [Fas] cross linking and cell lines devoid of functional PC-PLC activity could exhibit enhanced PLD activity by exogenous addition of PC-PLC . Positive_regulation FAS PLD3 11007187 735377 In an attempt to correlate the existence of PC-PLC activity and *activation* of by [Fas] activation among various Fas expressing murine cell lines , we have investigated the effect of anti-Fas monoclonal antibody on PC-PLC and PLD activities in A20 , P388D1 and YAC-1 cell lines . Positive_regulation FAS PLD3 11007187 735403 These findings suggest that the activation of PC-PLC is a necessary requirement for the *activation* of by [Fas] cross linking and cell lines devoid of functional PC-PLC activity could exhibit enhanced PLD activity by exogenous addition of PC-PLC . Positive_regulation FAS PLD4 11007187 735378 In an attempt to correlate the existence of PC-PLC activity and *activation* of by [Fas] activation among various Fas expressing murine cell lines , we have investigated the effect of anti-Fas monoclonal antibody on PC-PLC and PLD activities in A20 , P388D1 and YAC-1 cell lines . Positive_regulation FAS PLD4 11007187 735404 These findings suggest that the activation of PC-PLC is a necessary requirement for the *activation* of by [Fas] cross linking and cell lines devoid of functional PC-PLC activity could exhibit enhanced PLD activity by exogenous addition of PC-PLC . Positive_regulation FAS PLD5 11007187 735379 In an attempt to correlate the existence of PC-PLC activity and *activation* of by [Fas] activation among various Fas expressing murine cell lines , we have investigated the effect of anti-Fas monoclonal antibody on PC-PLC and PLD activities in A20 , P388D1 and YAC-1 cell lines . Positive_regulation FAS PLD5 11007187 735405 These findings suggest that the activation of PC-PLC is a necessary requirement for the *activation* of by [Fas] cross linking and cell lines devoid of functional PC-PLC activity could exhibit enhanced PLD activity by exogenous addition of PC-PLC . Positive_regulation FAS PLD6 11007187 735380 In an attempt to correlate the existence of PC-PLC activity and *activation* of by [Fas] activation among various Fas expressing murine cell lines , we have investigated the effect of anti-Fas monoclonal antibody on PC-PLC and PLD activities in A20 , P388D1 and YAC-1 cell lines . Positive_regulation FAS PLD6 11007187 735406 These findings suggest that the activation of PC-PLC is a necessary requirement for the *activation* of by [Fas] cross linking and cell lines devoid of functional PC-PLC activity could exhibit enhanced PLD activity by exogenous addition of PC-PLC . Positive_regulation FAS PNP 11526536 853197 HSV-tk/GCV , but not , *caused* up-regulation of [Fas] in p53 positive HepG2 cells and of Fas ligand (FasL) in both HCC cell lines . Positive_regulation FAS POLDIP2 12207331 983600 Further analysis with A3.01 T cells revealed that the proinflammatory signaling activity of [CD95] was *mediated* by MEK/ERK , and NF-kappaB signaling pathways . Positive_regulation FAS POT1 11809811 906835 On the other hand , activation could *restore* [FAs] in cells expressing FA-Csk. Activation of the executioner caspase , caspase 3 , is essential for many forms of apoptosis . Positive_regulation FAS PPARG 15644454 1402288 Furthermore , the regulated *induction* of both SREBP-1 and [FAS] parallels an increase in de novo triacylglycerol synthesis in hepatocytes . Positive_regulation FAS PPARGC1B 17932310 1825533 On HFD , overexpression decreased hepatic SREBP-1c , yet *increased* [FAS] and ACCalpha mRNA and plasma triglyceride levels . Positive_regulation FAS PPP2CA 20631069 2297398 ROS generation , [CD95] activation , and cell killing was also *blocked* by quenching of induced Ca ( 2+ ) levels or by inhibition of . Positive_regulation FAS PPP2CA 23184344 2827325 Inhibition of by okadaic acid , knockdown of DNA-PK by siRNA or inhibition of DNA-PK by specific DNA-PK inhibitors curtailed the FFA induced upregulations of the SREBP1 mRNA expression and the nuclear active SREBP1 protein expression , and *reduced* FFA induced upregulation of [FAS] promoter transcriptional activity and lipid accumulation . Positive_regulation FAS PPP2R1A 20631069 2297399 ROS generation , [CD95] activation , and cell killing was also *blocked* by quenching of induced Ca ( 2+ ) levels or by inhibition of . Positive_regulation FAS PPP2R1A 23184344 2827326 Inhibition of by okadaic acid , knockdown of DNA-PK by siRNA or inhibition of DNA-PK by specific DNA-PK inhibitors curtailed the FFA induced upregulations of the SREBP1 mRNA expression and the nuclear active SREBP1 protein expression , and *reduced* FFA induced upregulation of [FAS] promoter transcriptional activity and lipid accumulation . Positive_regulation FAS PPP2R2B 20631069 2297400 ROS generation , [CD95] activation , and cell killing was also *blocked* by quenching of induced Ca ( 2+ ) levels or by inhibition of . Positive_regulation FAS PPP2R2B 23184344 2827327 Inhibition of by okadaic acid , knockdown of DNA-PK by siRNA or inhibition of DNA-PK by specific DNA-PK inhibitors curtailed the FFA induced upregulations of the SREBP1 mRNA expression and the nuclear active SREBP1 protein expression , and *reduced* FFA induced upregulation of [FAS] promoter transcriptional activity and lipid accumulation . Positive_regulation FAS PPP5C 19679086 2119712 To be catalytically competent , the [FAS] must be *activated* by a posttranslational modification of the central acyl carrier domain ( ACP ) by an intrinsic . Positive_regulation FAS PRKAA1 17635921 1787606 Notably , activation *increased* threonine phosphorylation of [FAS] , and this effect was blocked by adenovirus encoding dominant negative AMPK . Positive_regulation FAS PRKAA1 17635921 1787612 Finally , *dependent* [FAS] phosphorylation was confirmed by ( 32 ) P incorporation into FAS in adipocytes . Positive_regulation FAS PRKAA2 17635921 1787607 Notably , activation *increased* threonine phosphorylation of [FAS] , and this effect was blocked by adenovirus encoding dominant negative AMPK . Positive_regulation FAS PRKAA2 17635921 1787613 Finally , *dependent* [FAS] phosphorylation was confirmed by ( 32 ) P incorporation into FAS in adipocytes . Positive_regulation FAS PRKAB1 17635921 1787608 Notably , activation *increased* threonine phosphorylation of [FAS] , and this effect was blocked by adenovirus encoding dominant negative AMPK . Positive_regulation FAS PRKAB1 17635921 1787614 Finally , *dependent* [FAS] phosphorylation was confirmed by ( 32 ) P incorporation into FAS in adipocytes . Positive_regulation FAS PRKAB2 17635921 1787609 Notably , activation *increased* threonine phosphorylation of [FAS] , and this effect was blocked by adenovirus encoding dominant negative AMPK . Positive_regulation FAS PRKAB2 17635921 1787615 Finally , *dependent* [FAS] phosphorylation was confirmed by ( 32 ) P incorporation into FAS in adipocytes . Positive_regulation FAS PRKACB 14699504 1195889 Inhibition of bile salt induced apoptosis by cAMP involves both *dependent* Ser/Thr phosphorylation of the [CD95] and inhibition of EGF-R activation , which results in an inhibition of CD95 tyrosine phosphorylation , CD95 membrane targeting , and DISC formation . Positive_regulation FAS PRKACG 14699504 1195890 Inhibition of bile salt induced apoptosis by cAMP involves both *dependent* Ser/Thr phosphorylation of the [CD95] and inhibition of EGF-R activation , which results in an inhibition of CD95 tyrosine phosphorylation , CD95 membrane targeting , and DISC formation . Positive_regulation FAS PRKAG1 17635921 1787610 Notably , activation *increased* threonine phosphorylation of [FAS] , and this effect was blocked by adenovirus encoding dominant negative AMPK . Positive_regulation FAS PRKAG1 17635921 1787616 Finally , *dependent* [FAS] phosphorylation was confirmed by ( 32 ) P incorporation into FAS in adipocytes . Positive_regulation FAS PRKAG2 17635921 1787611 Notably , activation *increased* threonine phosphorylation of [FAS] , and this effect was blocked by adenovirus encoding dominant negative AMPK . Positive_regulation FAS PRKAG2 17635921 1787617 Finally , *dependent* [FAS] phosphorylation was confirmed by ( 32 ) P incorporation into FAS in adipocytes . Positive_regulation FAS PRKAR1A 14699504 1195891 Inhibition of bile salt induced apoptosis by cAMP involves both *dependent* Ser/Thr phosphorylation of the [CD95] and inhibition of EGF-R activation , which results in an inhibition of CD95 tyrosine phosphorylation , CD95 membrane targeting , and DISC formation . Positive_regulation FAS PRKAR1B 14699504 1195892 Inhibition of bile salt induced apoptosis by cAMP involves both *dependent* Ser/Thr phosphorylation of the [CD95] and inhibition of EGF-R activation , which results in an inhibition of CD95 tyrosine phosphorylation , CD95 membrane targeting , and DISC formation . Positive_regulation FAS PRKAR2A 14699504 1195893 Inhibition of bile salt induced apoptosis by cAMP involves both *dependent* Ser/Thr phosphorylation of the [CD95] and inhibition of EGF-R activation , which results in an inhibition of CD95 tyrosine phosphorylation , CD95 membrane targeting , and DISC formation . Positive_regulation FAS PRKAR2B 14699504 1195894 Inhibition of bile salt induced apoptosis by cAMP involves both *dependent* Ser/Thr phosphorylation of the [CD95] and inhibition of EGF-R activation , which results in an inhibition of CD95 tyrosine phosphorylation , CD95 membrane targeting , and DISC formation . Positive_regulation FAS PSIP1 11897677 921459 Activation of the transcription nuclear factor-kappa B (NF-kappa B) is required for PIC induced inducible nitric oxide synthase expression in beta-cells , and we hypothesized that this transcription factor may also participate in *induced* [Fas] expression and beta-cell apoptosis . Positive_regulation FAS PSIP1 11897677 921473 Site directed mutations at the NF-kappa B and CCAAT/enhancer binding protein binding sites prevented *induced* [Fas] promoter activity . Positive_regulation FAS PTBP1 10698621 671900 Stimulation of T cells with at an S/R ratio of 5 *induced* a higher level of expression of [CD95 ligand (CD95L)] than stimulation of T cells cultured with DCs at an S/R ratio of 0.5 , whereas similar levels of expression of CD28 and CD154 were observed in both cells . Positive_regulation FAS PTBP1 23943615 2845257 Here , we show that CD11b ( hi ) Ia ( low ) regulatory expressed high level of Fas , and endothelial stromal cell derived TGF-ß could *induce* high expression of [Fas] on regulatory DCs via ERK activation . Positive_regulation FAS PTBP1 23943615 2845274 Furthermore , [Fas] ligation preferentially *induced* regulatory to produce IL-10 and IP-10 via ERK mediated inactivation of GSK-3 and subsequent up-regulation of ß-catenin . Positive_regulation FAS PTBP2 10698621 671897 Stimulation of T cells with at an S/R ratio of 5 *induced* a higher level of expression of [CD95 ligand (CD95L)] than stimulation of T cells cultured with DCs at an S/R ratio of 0.5 , whereas similar levels of expression of CD28 and CD154 were observed in both cells . Positive_regulation FAS PTBP2 23943615 2845254 Here , we show that CD11b ( hi ) Ia ( low ) regulatory expressed high level of Fas , and endothelial stromal cell derived TGF-ß could *induce* high expression of [Fas] on regulatory DCs via ERK activation . Positive_regulation FAS PTBP2 23943615 2845271 Furthermore , [Fas] ligation preferentially *induced* regulatory to produce IL-10 and IP-10 via ERK mediated inactivation of GSK-3 and subsequent up-regulation of ß-catenin . Positive_regulation FAS PTK2 20705914 2335556 *targeted* to VSMC [FAs] , despite previous studies in other cell types . Positive_regulation FAS PTPRC 8562955 349061 Our data suggest that although and Lck are not *required* for [Fas] signaling , JNK activation may play an important role transducing distal signals that lead to apoptosis after Fas ligation . Positive_regulation FAS PXN 22761432 2639481 Furthermore , whereas the ( presumably indirect ) interaction between paxillin and the C-terminal tail of talin led to dynamic FAs at the cell boundary , S85A did not bind talin and *caused* stabilized [FAs] in the central region of cells . Positive_regulation FAS PXN 23658024 2805370 Previous reports showed that overexpressed ILK in which Val ( 386 ) and Thr ( 387 ) were substituted with glycine residues ( ILK-VT/GG ) could neither interact with paxillin nor localize to FA in cells expressing endogenous wild-type ILK , implying that binding to ILK is *required* for its localization to [FAs] . Positive_regulation FAS PXN 9658172 516985 An avian paxillin-CHO.K1 model system was used to explore the *role* of phosphorylation in paxillin localization to [FAs] . Positive_regulation FAS QRICH1 12165276 972793 Studying normal peripheral lymphoproliferation , we also found that the presence of *increased* lymphoproliferation as well as Bcl-2 and [CD95] expression ; Positive_regulation FAS QRICH2 12165276 972794 Studying normal peripheral lymphoproliferation , we also found that the presence of *increased* lymphoproliferation as well as Bcl-2 and [CD95] expression ; Positive_regulation FAS RAC1 17982024 1820874 The ability of Rac1 to sensitize T cells to Fas induced apoptosis correlated with *mediated* cytoskeletal reorganization , dephosphorylation of the ERM ( ezrin/radixin/moesin ) family of cytoskeletal linker proteins , and the translocation of [Fas] to lipid raft microdomains . Positive_regulation FAS RAC1 18676874 1967456 Our results demonstrate that OxPAPC induced *dependent* , Rho independent peripheral accumulation of paxillin containing [FAs] and time dependent paxillin phosphorylation . Positive_regulation FAS RAC2 17982024 1820875 The ability of Rac1 to sensitize T cells to Fas induced apoptosis correlated with *mediated* cytoskeletal reorganization , dephosphorylation of the ERM ( ezrin/radixin/moesin ) family of cytoskeletal linker proteins , and the translocation of [Fas] to lipid raft microdomains . Positive_regulation FAS RAC2 18676874 1967457 Our results demonstrate that OxPAPC induced *dependent* , Rho independent peripheral accumulation of paxillin containing [FAs] and time dependent paxillin phosphorylation . Positive_regulation FAS RAC3 17982024 1820876 The ability of Rac1 to sensitize T cells to Fas induced apoptosis correlated with *mediated* cytoskeletal reorganization , dephosphorylation of the ERM ( ezrin/radixin/moesin ) family of cytoskeletal linker proteins , and the translocation of [Fas] to lipid raft microdomains . Positive_regulation FAS RAC3 18676874 1967458 Our results demonstrate that OxPAPC induced *dependent* , Rho independent peripheral accumulation of paxillin containing [FAs] and time dependent paxillin phosphorylation . Positive_regulation FAS RAD50 11809811 906838 On the other hand , activation could *restore* [FAs] in cells expressing FA-Csk. Activation of the executioner caspase , caspase 3 , is essential for many forms of apoptosis . Positive_regulation FAS RELA 10022897 590538 Activation dependent transcriptional regulation of the human [Fas] promoter *requires* p50-p65 recruitment . Positive_regulation FAS RELA 10092091 600396 *regulates* [Fas/APO-1/CD95-] and TCR- mediated apoptosis of T lymphocytes . Positive_regulation FAS RELA 10640741 660633 STAT-1alpha and activation are *involved* in IFN-gamma- or TNF-alpha mediated [Fas] up-regulation in microglia , respectively . Positive_regulation FAS RELA 10671224 666701 T cell activation induced and HIV tat enhanced [CD95] ( APO-1/Fas ) ligand transcription *involves* . Positive_regulation FAS RELA 11464292 839430 Inhibition of protein kinase C by Gö6983 sensitized these cells to apoptotic challenges and strongly diminished *activation* of by [anti-CD95] and TRAIL . Positive_regulation FAS RELA 12244143 990501 Fas resistance of leukemic eosinophils is due to *activation* of by [Fas] ligation . Positive_regulation FAS RELA 12244143 990507 Although *activation* of by ligation of [Fas] ( CD95/Apo-1 ) , a member of the TNFR family , has been observed in a few studies , Fas mediated NF-kappaB activation has not previously been shown to protect cells from apoptosis . Positive_regulation FAS RELA 12883671 1116467 [Fas] stimulation *induced* activation in a dose dependent manner in SK-Hep1 and HepG2 cell lines , but not in HLE cells . Positive_regulation FAS RELA 14625298 1200946 Caffeic acid phenethyl ester induces apoptosis by inhibition of and *activation* of [Fas] in human breast cancer MCF-7 cells . Positive_regulation FAS RELA 14693245 1194880 Our results suggest that activated at early stages in the okadaic acid treated SCC-25 cells *stimulated* the promoter activity of [Fas] receptor in the cells leading to the apoptotic death of these cells . Positive_regulation FAS RELA 15143063 1267521 dependent *induction* of tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) and [Fas/FasL] is crucial for efficient influenza virus propagation . Positive_regulation FAS RELA 15302589 1283976 Synergistic *induction* of the [Fas] ( CD95) ligand promoter by Max and in human non-small lung cancer cells . Positive_regulation FAS RELA 15382040 1298802 Arsenic trioxide sensitizes CD95/Fas induced apoptosis through ROS mediated *upregulation* of [CD95/Fas] by activation . Positive_regulation FAS RELA 15382040 1298804 Furthermore , inhibition of by transient transfection of IkappaBalpha supersurppessor *blocked* the increase of [CD95/Fas] expression following As2O2 treatment . Positive_regulation FAS RELA 15382040 1298807 These findings demonstrate that sensitization of human cervical cancer cells to CD95/Fas mediated apoptosis by As2O3 can be partly due to induction of ROS and subsequent *upregulation* of [CD95/Fas] gene expression by activation . Positive_regulation FAS RELA 15514680 1328471 Induction of apoptosis and *activation* of by [CD95] require different signalling thresholds . Positive_regulation FAS RELA 16317104 1526233 Epstein-Barr virus ( EBV ) induces CD95 expression and the [CD95] gene ( FAS ) is *regulated* by , STAT1 , and/or p53 . Positive_regulation FAS RELA 17118453 1667832 Besides the apoptosis signaling pathway , [CD95] ligation also *induces* the activation of . Positive_regulation FAS RELA 17291719 1725811 Caspase mediated activation of and ERKs were *involved* in [CD95L-] and TRAIL induced up-regulation of proinflammatory genes in Colo357-BclxL cells . Positive_regulation FAS RELA 17786316 1790930 The inverse activities of [Fas] and FasL promoter in tumor cells are *regulated* by , which inhibits Fas expression and increases FasL expression through binding to their respective promoters . Positive_regulation FAS RELA 18448526 1921249 Therefore , our results are in agreement with a model where LMP1 dependent activation *induces* [Fas] overexpression and autoactivation that could overwhelm the antiapoptotic effect of NF-kappaB , revealing an ambivalent function of LMP1 in cell survival and programmed cell death . Positive_regulation FAS RELA 7523113 272176 Whereas transcription factor was readily activated by TNF , activation was not *induced* by triggering [APO-1/Fas] . Positive_regulation FAS RELA 8939996 398732 In addition , our results demonstrate that [CD95] mediated signaling *involves* activation of ( p50/RelA ) . Positive_regulation FAS RELA 9525905 495456 Moreover , inhibition of activity by a transdominant IkappaB mutant *attenuated* [CD95L] expression . Positive_regulation FAS RNF19A 15317908 1286366 Death promoting effects have been ascribed to inhibition of nuclear factor-kappaB , increase of [Fas] expression , p53 stabilization , cytokine and chemokine release , and *activation* of nitric oxide synthase , , and c-Jun-N-terminal kinase . Positive_regulation FAS S11 12773535 1119712 The principle described here for the first time , in which *mediated* activation of [Fas] permits local activation of Fas in vivo , opens novel avenues for the use of Fas signaling in cancer therapy . Positive_regulation FAS S12 12773535 1119713 The principle described here for the first time , in which mediated *activation* of [Fas] permits local activation of Fas in vivo , opens novel avenues for the use of Fas signaling in cancer therapy . Positive_regulation FAS S7 12773535 1119714 The principle described here for the first time , in which *mediated* activation of [Fas] permits local activation of Fas in vivo , opens novel avenues for the use of Fas signaling in cancer therapy . Positive_regulation FAS SBDS 19009351 2016510 These results suggest that loss *results* in abnormal accumulation of [Fas] at the plasma membrane , where it sensitizes the cells to stimulation by Fas ligand . Positive_regulation FAS SERPINB9 16179941 1517502 The *role* of in [CD95] signaling : new insights into the mechanism of procaspase-8 activation . Positive_regulation FAS SLC22A3 22508480 2744712 However , this pathway has also been shown to promote tumor cell motility , leading to the hypothesis that [Fas] signaling may *induce* to promote metastasis . Positive_regulation FAS SLC22A3 22508480 2744716 Moreover , oxaliplatin , a chemotherapeutic agent , *induced* partly through [Fas] signaling . Positive_regulation FAS SLC22A3 22508480 2744718 Altogether , these data indicate that [Fas] signaling may *induce* to promote tumor motility and metastasis in GI cancer in vivo and in vitro . Positive_regulation FAS SLC33A1 10325958 612829 During exposure of HCAECs to anoxia-reoxygenation and Ang II , activation *induces* important changes in cNOS mRNA , protein expression and activity , as well as bcl-2 and [Fas] protein expression which may have a bearing on the development of apoptosis . Positive_regulation FAS SLCO6A1 19417161 2179804 *caused* plasma membrane clustering of CD95 and the association of [CD95] with procaspase-8 . Positive_regulation FAS SLCO6A1 19417161 2179820 Our data show that in kidney cancer cells *induces* ceramide dependent activation of [CD95] , which is causal in promoting an endoplasmic reticulum stress response that activates multiple proapoptotic pathways to decrease survival . Positive_regulation FAS SMOX 16820946 1581609 *induced* the up-regulation of [Fas] and the release of soluble FasL ( sFasL ) from infected cells but cell treatment with antagonist anti-Fas did not completely abrogate apoptosis suggesting that , besides the activated Fas-FasL pathway , other mechanisms are likely to be associated with the induction of apoptosis . Positive_regulation FAS SMPD1 15939338 1415515 Special attention is given to changes in plasma membrane fluidity , *activation* of the and the [Fas] death pathway in response to chemotherapy as well as their possible interrelationships . Positive_regulation FAS SNAP25 17343612 1707859 and finally , the NO donor *induces* considerable [Fas] up-regulation in tumours in vitro . Positive_regulation FAS SP1 10671504 666817 In contrast , carbohydrate activation of the [FAS] promoter in primary hepatocytes is *dependent* upon SREBP and both the and CCAAT binding factor/nuclear factor Y sites . Positive_regulation FAS SP1 7592729 330145 It is also demonstrated that SREBP and synergistically *activate* the [FAS] promoter in Drosophila tissue culture cells , which lack endogenous Sp1 . Positive_regulation FAS SPN 16953114 1610958 Further , signaling of Jurkat cells *induced* [Fas] oligomerization on the cell surfaces implying that CD43 ligation have effects on early stage of Fas induced T cell death . Positive_regulation FAS SREBF1 14690455 1211518 Real-time PCR ( TaqMan ) analysis showed that *up-regulated* the expression of [FAS] ( fatty acid synthase ; 6-fold ) , acetyl-CoA carboxylase-1 ( 2-fold ) , as well as peroxisomal-proliferator activated receptor-gamma ( 7-fold ) , uncoupling protein-2 ( 1.4-fold ) and Bcl2 ( B-cell lymphocytic-leukaemia proto-oncogene 2 ; 1.3-fold ) . Positive_regulation FAS SREBF1 16162944 1475995 Conversely , adenovirus mediated overexpression of a dominant negative form of *inhibited* the KGF effect on [FAS] and SCD-1 expression . Positive_regulation FAS SREBF1 16162944 1476001 In summary , we conclude that KGF requires both PI3K and JNK signaling pathways to induce , which in turn *induces* SCD-1 and [FAS] expression in H292 cells . Positive_regulation FAS SREBF1 18079124 1868205 The mRNA expression of lipogenic genes Scd-1 and [Fas] is *regulated* partly by the insulin-sensitive transcription factor and liver X receptor alpha ( LXRalpha ) . Positive_regulation FAS SREBF1 18420801 1899747 We also showed that [FAS] upregulation by HCV NS2 was *dependent* since deleting the SRE sequence in a FAS promoter and expressing a dominant negative SREBP-1 abrogated FAS promoter upregulation by HCV NS2 . Positive_regulation FAS ST3GAL4 24374093 2911722 Further experiments showed that the *induced* protein levels of tumor necrosis factor-alpha (TNF-alpha) , [Fas] , activated caspase-8 and caspase-3 were significantly inhibited by the GABA tea treatment . Positive_regulation FAS STAT1 11309387 834245 Moreover , is *critical* for the induction of [Fas] receptor and Fas ligand expression by ischemia/reperfusion ( I/R ) . Positive_regulation FAS STAT1 11309387 834247 These results indicate that [Fas/FasL] genes and apoptosis are *activated* by in cardiac myocytes exposed to I/R and these effects are dependent on the Ser-727 but not the Tyr-701 phosphorylation sites of STAT-1 . Positive_regulation FAS STAT1 16317104 1526230 Epstein-Barr virus ( EBV ) induces CD95 expression and the [CD95] gene ( FAS ) is *regulated* by NF-kappaB , , and/or p53 . Positive_regulation FAS STAT3 11463377 843409 The expression of dominant negative or c-Jun in melanoma cells efficiently *increased* [Fas] expression and sensitized cells to FasL induced apoptosis . Positive_regulation FAS STAT3 21468569 2413161 *enhances* intracellular [Fas] mediated apoptotic signals in HHUA human endometrial epithelial cells . Positive_regulation FAS STC1 23132899 2696540 We found that induces apoptosis in these cells in a dose dependent manner and *leads* to the activation of [Fas] and caspase-8 , cleavage of Bid , mitochondrial damage , and activation of caspase-3 . Positive_regulation FAS SYT1 10022897 590536 Activation dependent transcriptional regulation of the human [Fas] promoter *requires* NF-kappaB recruitment . Positive_regulation FAS TAC1 15796164 1387238 did not affect the expression of Fas ligand , but obviously *increased* the expression of [Fas] in the metastatic tumors . Positive_regulation FAS TAC1 17436592 1729052 Although TAC-101 did not change the expression of TNF-R1 and DR3 , *increased* the expression of [Fas] in both a time- and a dose dependent manner . Positive_regulation FAS TAC3 15796164 1387239 did not affect the expression of Fas ligand , but obviously *increased* the expression of [Fas] in the metastatic tumors . Positive_regulation FAS TAC3 17436592 1729053 Although TAC-101 did not change the expression of TNF-R1 and DR3 , *increased* the expression of [Fas] in both a time- and a dose dependent manner . Positive_regulation FAS TAC4 15796164 1387240 did not affect the expression of Fas ligand , but obviously *increased* the expression of [Fas] in the metastatic tumors . Positive_regulation FAS TAC4 17436592 1729054 Although TAC-101 did not change the expression of TNF-R1 and DR3 , *increased* the expression of [Fas] in both a time- and a dose dependent manner . Positive_regulation FAS TAPBP 15034728 1257214 In contrast , with lipid *increased* the expression of [Fas] and both the pro-apoptotic factor Bad and the anti-apoptotic factor Bcl-xl ( p < 0.05 ) . Positive_regulation FAS TAT 9268734 450087 Reverse transcriptase-PCR further demonstrated that *induced* [Fas] expression in B cells at the mRNA level . Positive_regulation FAS TCF12 15240700 1270385 The E2F-1 promotes caspase-8 and bid expression , and *enhances* [Fas] signaling in T cells . Positive_regulation FAS TCF15 15240700 1270386 The E2F-1 promotes caspase-8 and bid expression , and *enhances* [Fas] signaling in T cells . Positive_regulation FAS TCF19 15240700 1270387 The E2F-1 promotes caspase-8 and bid expression , and *enhances* [Fas] signaling in T cells . Positive_regulation FAS TCF20 15240700 1270388 The E2F-1 promotes caspase-8 and bid expression , and *enhances* [Fas] signaling in T cells . Positive_regulation FAS TCF21 15240700 1270389 The E2F-1 promotes caspase-8 and bid expression , and *enhances* [Fas] signaling in T cells . Positive_regulation FAS TCF23 15240700 1270393 The E2F-1 promotes caspase-8 and bid expression , and *enhances* [Fas] signaling in T cells . Positive_regulation FAS TCF24 15240700 1270395 The E2F-1 promotes caspase-8 and bid expression , and *enhances* [Fas] signaling in T cells . Positive_regulation FAS TCF25 15240700 1270394 The E2F-1 promotes caspase-8 and bid expression , and *enhances* [Fas] signaling in T cells . Positive_regulation FAS TCF3 15240700 1270390 The E2F-1 promotes caspase-8 and bid expression , and *enhances* [Fas] signaling in T cells . Positive_regulation FAS TCF4 15240700 1270391 The E2F-1 promotes caspase-8 and bid expression , and *enhances* [Fas] signaling in T cells . Positive_regulation FAS TCF7 15240700 1270392 The E2F-1 promotes caspase-8 and bid expression , and *enhances* [Fas] signaling in T cells . Positive_regulation FAS TERF1 11809811 906832 On the other hand , activation could *restore* [FAs] in cells expressing FA-Csk. Activation of the executioner caspase , caspase 3 , is essential for many forms of apoptosis . Positive_regulation FAS TERF2 11809811 906833 On the other hand , activation could *restore* [FAs] in cells expressing FA-Csk. Activation of the executioner caspase , caspase 3 , is essential for many forms of apoptosis . Positive_regulation FAS TERF2IP 11809811 906836 On the other hand , activation could *restore* [FAs] in cells expressing FA-Csk. Activation of the executioner caspase , caspase 3 , is essential for many forms of apoptosis . Positive_regulation FAS TFPT 14596819 1160344 Results indicated that can *induce* [CD95] modulated signaling when TNFalpha is absent . Positive_regulation FAS TGFB1 10924745 718407 Flow cytometric analyses demonstrated that , IL-1beta , and EGF did not *induce* [Fas] expression on the cell surface . Positive_regulation FAS TGFB1 11596030 870249 The *role* of ( TGF-beta1 ) in modulating the expression of [Fas] by CTLs is not known in HCC . Positive_regulation FAS TGFB1 14595120 1200204 We showed that *induced* the expression and activation of [Fas] and the subsequent caspase-8 mediated Bid cleavage . Positive_regulation FAS TGFB1 14595120 1200205 Interestingly , expression of dominant negative FADD and treatment with caspase-8 inhibitor efficiently prevented TGF-beta 1-induced apoptosis , whereas the treatment with an activating CH11 or a neutralizing ZB4 anti-Fas antibody , recombinant Fas ligand , or Fas-Fc chimera did not affect activation of [Fas] and the subsequent *induction* of apoptosis by . Positive_regulation FAS THY1 10700471 672325 It is shown that glycophosphatidylinositol linked surface glycoprotein preferentially *activates* [FasL-Fas-] but not perforin mediated cytotoxicity . Positive_regulation FAS TIMP3 18157585 1918893 treatment *induced* the expression of [Fas] and Fasl proteins , and the activation of caspase-8 and caspase-3 . Positive_regulation FAS TINF2 11809811 906834 On the other hand , activation could *restore* [FAs] in cells expressing FA-Csk. Activation of the executioner caspase , caspase 3 , is essential for many forms of apoptosis . Positive_regulation FAS TNF 10457352 639312 In colonic organ cultures , IFNgamma and also *enhanced* colonocyte [FAS] expression , resulting in a markedly increased apoptotic response to stimulation of this receptor , as shown by in situ terminal deosyuridine triphosphate nick-end staining . Positive_regulation FAS TNF 10482306 643821 *augmented* both [Fas] expression and Fas mediated apoptosis more efficiently than did IL-1beta . Positive_regulation FAS TNF 10504483 648930 These data are supported by in vitro studies that showed that interleukin-1alpha or , cytokines that are secreted in chronic renal failure , *stimulated* increases in [Fas] expression in cultured RTCs . Positive_regulation FAS TNF 10544178 563983 treatment of LEC-1 *induced* up-regulation of [Fas] receptor on these cells . Positive_regulation FAS TNF 10580567 570094 This pro-apoptotic effect of TNF was explained at least in part by a *mediated* enhancement of [Fas] expression . Positive_regulation FAS TNF 10632976 659839 It has previously been shown that interferon-gamma (IFN-gamma) and together *increase* [CD95] surface expression on eosinophils . Positive_regulation FAS TNF 10632976 659841 We therefore investigated whether the increase in [CD95] expression *mediated* by indeed translates into increased , FasL mediated apoptosis of eosinophils . Positive_regulation FAS TNF 10632976 659843 This increase in CD95/FasL mediated apoptosis was correlated with an *mediated* increase in [CD95] expression . Positive_regulation FAS TNF 10895367 711569 Our findings suggest that IFN-gamma or secreted by infiltrating lymphocytes *induces* ductal [Fas] expression and ductal apoptosis in sialoadenitis associated with SS . Positive_regulation FAS TNF 10985496 732356 The addition of vitamin K2 to the culture resulted in a dose dependent inhibition of functional [Fas] expression on osteoblasts , in the *presence* or absence of . Positive_regulation FAS TNF 12021072 942782 IFN-gamma and *promote* [Fas] expression and sensitivity , whereas IL-6 and IL-10 increase the resistance of trophoblast cells to Fas mediated apoptosis . Positive_regulation FAS TNF 12086911 959293 can *cause* liver cell apoptosis through the TNF alpha receptor or [Fas/CD95] which is expressed by liver cells . Positive_regulation FAS TNF 12181748 977865 IkappaBalpha super repressor expression blocked the increase of whole cell and cell surface [FAS] expression *induced* by , but did not effect induction of FAS expression and cell surface FAS expression that resulted from irradiation . Positive_regulation FAS TNF 12391181 1007226 Apoptosis of the adherent cells was markedly inhibited by anti-Fas ligand (FasL) Ab. RT-PCR and FACS analyses revealed that up-regulated Fas transcription to lead to Fas expression on the surfaces of the adherent cells , whereas IL-12 could not *induce* [Fas] on the cells . Positive_regulation FAS TNF 12391181 1007233 These results implied that apoptosis of the adherent cells in bone marrow cells might be caused by interaction between *induced* [Fas] on the adherent cells and IL-12 induced FasL on the nonadherent cells . Positive_regulation FAS TNF 12513829 1027772 and interferon-gamma (IFN-gamma) further *increased* the [CD95] expression induced by positive cytokines . Positive_regulation FAS TNF 12658775 1030339 The combinations of cytokines such as SCF + FL could up-regulate the expression of [CD95] in vitro culture and and interon-gamma ( IFN-gamma ) further *increased* the CD95 expression induced by positive cytokines . Positive_regulation FAS TNF 12717381 1083837 Keratin mutation in transgenic mice predisposes to [Fas] but not *induced* apoptosis and massive liver injury . Positive_regulation FAS TNF 12761580 1091677 On the other hand , [Fas] expression was strongly *enhanced* by , and inhibition of TNF/IFN-alpha induced NF-kappaB activation , by using NF-kappaB decoy , decreased Fas expression . Positive_regulation FAS TNF 12813034 1120729 In addition , NF kappa B downstream of TNFR was required for *up-regulation* of [Fas] expression by endogenous secreted in response to TCR stimulation . Positive_regulation FAS TNF 14693705 1194895 IL-1 action was not required for *induction* of class I major histocompatibility complex or [Fas] by and IFN-gamma . Positive_regulation FAS TNF 14729358 1198389 In the primary cultured cells , *induced* an important upregulation of ICAM-1 , [Fas] and CD40 whereas CD44 and CD63 were significantly decreased . Positive_regulation FAS TNF 15160396 1252759 In addition to direct cytotoxic effects , IFN-gamma and also *enhance* the expression of [Fas] , TNFR1 , and MHC class I molecules in both cell lines . Positive_regulation FAS TNF 15207753 1261680 *increased* the expression of Fas mRNA and cell surface [Fas] expression . Positive_regulation FAS TNF 15279653 1277468 These results suggest that the enhancement of the apoptosis caused by TNF-alpha resulted from increased sensitivity of the HSG cells to CH-11 mediated apoptosis due to *induction* of [Fas] protein by via the activation of NFkappaB . Positive_regulation FAS TNF 15502938 1342898 Involvement of receptor 1 and tumor necrosis factor related apoptosis *inducing* ligand- ( TRAIL ) receptor-2/DR-5 , but not [Fas] , in graft injury in live-donor liver transplantation . Positive_regulation FAS TNF 15601669 1375273 In the present paper , we have investigated the signal transduction mechanisms involved in the regulation of [Fas] expression *induced* by in mouse Sertoli cells . Positive_regulation FAS TNF 15601669 1375278 Moreover , the use of the proteasome inhibitor lactacystin led us to demonstrate that NF-kappaB is required for *mediated* [Fas] expression . Positive_regulation FAS TNF 15601669 1375279 By using specific inhibitors for each MAPK , we confirmed the pivotal role of the IkappaB/NF-kappaB system by demonstrating that ERKs , p38 , and JNK are not involved in [Fas] *up-regulation* by . Positive_regulation FAS TNF 15879156 1406164 Gene transfer of TIMP-3 inhibits the TNF-alpha induced activation of NF-kappaB in rheumatoid arthritis synovial fibroblasts and reduces the *up-regulation* of soluble [Fas/CD95] by , but has no effects on the cell surface expression of Fas . Positive_regulation FAS TNF 16555058 1604173 The expressing tumors *up-regulated* [Fas] ( CD95 ) expression and inhibited the expression of tumor metastasis associated molecule CD44v3 . Positive_regulation FAS TNF 17159605 1678910 The [Fas-Fas] ligand interaction between macrophages and L929 cells *increased* the expression of Fas associated death domain , and tumor necrosis factor-tumor necrosis factor receptor 1 interaction between macrophages and L929 cells increased the expression of receptor associated death domain in L929 cells . Positive_regulation FAS TNF 18047930 1846650 CMV enhanced development of CAN was associated with tubular apoptosis and concomitant increase of , rather than the [FAS-FAS-ligand] *activation* . Positive_regulation FAS TNF 19400895 2089516 IFN-gamma and *up-regulated* TNFR1 , TNFR2 , [Fas] and membrane FasL on SMC . Positive_regulation FAS TNF 19651258 2138483 We previously reported that IL-12 induces apoptosis in bone marrow cells treated with TNF-alpha in vitro via an interaction between *induced* [Fas] and IL-12 induced Fas ligand (FasL) , and that , as a result , osteoclastogenesis is inhibited . Positive_regulation FAS TNF 19651258 2138492 These results suggest that IL-12 inhibits TNF-alpha mediated osteoclastogenesis and induces apoptotic changes through an interaction between *induced* [Fas] and IL-12 induced FasL , in vivo , via a T cell independent mechanism . Positive_regulation FAS TNF 20541824 2301944 The expression of iNOS and the promoting apoptosis gene Bax and [Fas] were significantly *up-regulated* by the induction of IL-1beta and . Positive_regulation FAS TNF 21611811 2441801 We have reported that IL-12 and IL-18 induce apoptosis in bone marrow cells treated with TNF-a in vitro and that osteoclastogenesis is inhibited by the interaction of *induced* [Fas] and the IL-12 induced Fas ligand (FasL) . Positive_regulation FAS TNF 21816064 2472807 High glucose increased TNF-a production by HCAECs and exogenous *up-regulated* TNF-R1 and [Fas] expression in HCAECs . Positive_regulation FAS TNF 22305016 2565174 Suppression of phosphorylated JNK by the JNK inhibitor SP600125 greatly diminished *induced* expression of [FAS] and SREBP-1 . Positive_regulation FAS TNF 23604035 2810402 We first observed that [Fas] was *induced* by in the HL60 cell line . Positive_regulation FAS TNF 24396708 2884011 The well characterized *induced* expression of [Fas] is mediated by both TNF receptors , yet the TNF receptors determine survival rather than Fas : superior viability of TNF-R1 progenitors . Positive_regulation FAS TNF 7523113 272174 Whereas transcription factor NF-kappa B was readily activated by , activation was not *induced* by triggering [APO-1/Fas] . Positive_regulation FAS TNF 7538820 306903 [Fas] antigen expression on lymphocytes is *regulated* by interferon gamma (IFN gamma) and , cytokines that also have inhibitory effects on hematopoiesis . Positive_regulation FAS TNF 7538820 306907 Stimulation by and IFN gamma markedly *increased* [Fas] antigen expression on CD34+ cells . Positive_regulation FAS TNF 7542501 314114 However , IFN-gamma and/or *induced* the expression of both the mRNA of Fas and [Fas] itself in a dose dependent fashion on the surface of CD34+ cells after 48 hours of serum-free culture . Positive_regulation FAS TNF 7542501 314117 IFN-gamma and *had* a synergistic effect on the induction of [Fas] , when both cytokines were added to the culture . Positive_regulation FAS TNF 7542501 314122 The TNF-alpha induced [Fas] expression is *mediated* by p55 receptor . Positive_regulation FAS TNF 7542501 314125 These observations indicate that IFN-gamma and/or , well known as negative hematopoietic regulators , *induce* functional [Fas] on hematopoietic progenitor cells . Positive_regulation FAS TNF 7577642 333275 Interferon-gamma (IFN-gamma) and , potent inhibitors of haemopoiesis , *enhance* [Fas] receptor expression on bone marrow ( BM ) CD34+ cells , and both cytokines render haemopoietic progenitor cells susceptible to Fas mediated inhibition of colony formation due to the induction of apoptosis . Positive_regulation FAS TNF 8648118 363668 As [CD95] and TNF receptor are similar , and receptor binding *induces* oxygen radicals , the involvement of oxidant and antioxidant systems in CD95 mediated apoptosis has been examined . Positive_regulation FAS TNF 8741668 377113 However , interferon-gamma(IFN-gamma) and/or *induced* the expression of [Fas] after 48 hours of serum-free culture . Positive_regulation FAS TNF 8741668 377116 The TNF-alpha induced [Fas] expression is *mediated* by receptor . Positive_regulation FAS TNF 8822920 384849 and interferon-gamma (IFN-gamma) further *increased* the [CD95] expression induced by KL+GM-CSF . Positive_regulation FAS TNF 9049961 406020 However , interferon-gamma (IFN-gamma) and/or *induced* dose dependent expression of both Fas mRNA and [Fas] protein on the surface of CD34+ cells after 48 hours of serum-free culture . Positive_regulation FAS TNF 9163602 432081 CD34+ cell [Fas-R] expression was *increased* by IFN-gamma and . Positive_regulation FAS TNF 9187937 437070 However , coincubation with NG-monomethyl-L-arginine , an inhibitor of nitric oxide ( NO ) synthesis , inhibited the upregulation of [Fas] *induced* by IL-1 and . Positive_regulation FAS TNF 9255761 447746 Although all myelomonocytic cell lines expressed Fas on their cell surface , significantly *up-regulated* the expression of [Fas] in only OM-10.1 cells . Positive_regulation FAS TNF 9351390 461133 In culture , stimulation with interferon-gamma , , and interleukin-1 beta *increased* expression of [Fas] in SMCs . Positive_regulation FAS TNF 9384699 408095 [CD95] was *induced* by in 6/12 myeloid leukemia cell lines , and by IFN in 9/12 cell lines . Positive_regulation FAS TNF 9401054 469427 [Fas-receptor (Fas-R)] expression can be *stimulated* by IFN-gamma and . Positive_regulation FAS TNF 9973455 596169 3 ) [Fas] is also expressed constitutively and is *up-regulated* by IL-1 , IL-6 , or in which the pretreatment of IFN-gamma triggers astrocytes to express more Fas ; Positive_regulation FAS TNFRSF10B 12297830 991425 Betaine uptake was required for this protective effect , which was already observed at betaine concentrations of 1 mmol/L. Betaine did not affect the TLCS induced membrane trafficking of [CD95] and tumor necrosis factor related apoptosis *inducing* ligand ( to the plasma membrane or the TLCS induced recruitment of Fas associated death domain (FADD) and caspase 8 to the CD95 receptor . Positive_regulation FAS TNFRSF1A 17159605 1678911 The [Fas-Fas] ligand interaction between macrophages and L929 cells *increased* the expression of Fas associated death domain , and tumor necrosis interaction between macrophages and L929 cells increased the expression of tumor necrosis factor receptor associated death domain in L929 cells . Positive_regulation FAS TNFRSF1A 18047930 1846651 CMV enhanced development of CAN was associated with tubular apoptosis and concomitant increase of , rather than the [FAS-FAS-ligand] *activation* . Positive_regulation FAS TNFRSF1A 8741668 377117 The TNF-alpha induced [Fas] expression is *mediated* by receptor . Positive_regulation FAS TNFRSF1B 17254331 1696549 [Fas] upregulation in beta cells is *mediated* by , and colocalization of TNFR2 with the adaptor TRAF2 in NOD beta cells is altered . Positive_regulation FAS TNFRSF8 20812013 2336334 We aimed to reveal regulatory mechanisms of *induced* effects on [CD95] signaling of cALCL cell lines . Positive_regulation FAS TNFRSF9 11465097 839598 These results demonstrated that costimulation *induces* a rapid induction of [CD95L] on CD4+ T cells and leads to apoptosis of CD95-sensitive target cells . Positive_regulation FAS TNFSF10 15536394 1336462 Expression of [Fas] , DR4 , and DR5 is *detected* on the cell membrane of erythroblasts in all stages , whereas FasL and are present only in more mature erythroblasts . Positive_regulation FAS TNFSF11 15619676 1357664 *regulates* [Fas] expression and Fas mediated apoptosis in osteoclasts . Positive_regulation FAS TNFSF11 15619676 1357671 During the early stage of osteoclastogenesis ( 1 day ) when Fas is expressed at a very low level , *upregulates* [Fas] promoter activity by 2.4 +/- 0.1-fold in a concentration dependent manner and increases Fas mRNA and protein . Positive_regulation FAS TNFSF11 15619676 1357672 In osteoclast precursors , the *induction* of [Fas] promoter activity by was dramatically reduced when NF-kappaB binding sites on the Fas promoter were mutated . Positive_regulation FAS TNFSF11 15619676 1357673 *upregulates* [Fas] expression in osteoclast progenitors through NF-kappaB , making osteoclasts targets of Fas stimulated apoptosis . Positive_regulation FAS TNFSF11 16924474 1608674 Fusion proteins of RANK and CD95L ( RANKed CD95Led ) and CD40 and tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) ( CD40ed TRAILed ) , with domain architectures similar to CD40ed Cd95Led , displayed *dependent* [CD95] and CD40L dependent TRAILR2 activation , respectively , indicating the principle feasibility of this fusion protein design . Positive_regulation FAS TNFSF11 17371940 1760203 By contrast , [Fas] expression of BMDCs from normal C57BL/6 and MRL ( +/+ ) mice was *increased* by stimulation , and an enhanced DC apoptosis was found when stimulated with both RANKL and anti-Fas mAb , which was associated with activation of caspase-3 and caspase-9 . Positive_regulation FAS TNFSF13 17357108 1720340 Consistently , , which binds to TACI and B cell maturation antigen but not BAFF-R , did not *enhance* [Fas] expression on LPS activated B cells . Positive_regulation FAS TNFSF13B 17357108 1720337 *Up-regulation* of [Fas/CD95] by is restricted to B cells activated through TLR-4 , but not through TLR-9 , BCR or CD40 . Positive_regulation FAS TNFSF13B 17357108 1720338 This suggests the *up-regulation* of [Fas] by is mediated by BAFF-R and not by TACI . Positive_regulation FAS TNFSF15 14965271 1208863 For example , TNFalpha activates TNF-R1 while FasL and *activate* [Fas] and DR3 respectively . Positive_regulation FAS TNFSF15 9880523 583961 *up-regulated* [Fas] expression in BPAEC at 8 and 24 h after treatment , and significantly activated stress activated protein kinase ( SAPK ) and p38 mitogen activated protein kinase ( p38 MAPK ) . Positive_regulation FAS TP53 10080943 597528 Lack of correlation in JNK activation and *dependent* [Fas] expression induced by apoptotic stimuli . Positive_regulation FAS TP53 10080943 597529 Induction of [Fas] expression by DNA damaging agents is *dependent* on the expression of functional , and has been suggested to play an important role in apoptosis induction . Positive_regulation FAS TP53 10200513 561123 It has been reported that *upregulates* [Fas/APO-1] and Bax expression . Positive_regulation FAS TP53 10200513 561126 These results suggest that functional is *necessary* for the activation of Bax and [Fas/APO-1] expression . Positive_regulation FAS TP53 10352342 617278 *enhances* BAK and [CD95] expression in human malignant glioma cells but does not enhance CD95L induced apoptosis . Positive_regulation FAS TP53 10352342 617279 Wild-type , but not mutant , *enhanced* [CD95] expression in all cell lines . Positive_regulation FAS TP53 10352342 617281 Thus , wild-type *induces* BAK and [CD95] expression in human glioma cells without enhancing their susceptibility to CD95 mediated apoptosis , and mutant p53 modulates CD95L evoked apoptotic signalling in a gain-of-function fashion up-stream and down-stream of caspase 3 activation . Positive_regulation FAS TP53 10411938 630817 Here we show that TK/GCV treatment induces p53 accumulation and increases cell surface expression of CD95 and tumor necrosis factor receptor , which is likely to involve *mediated* translocation of [CD95] to the cell surface . Positive_regulation FAS TP53 10574967 569376 Thus , dependent , [Fas/APO-1] *mediated* apoptosis can be induced in breast cancer cells with mutant p53 similar to the recently described Fas/APO-1 induced apoptosis by wt p53 . Positive_regulation FAS TP53 10574967 569377 However , mutant without p53 peptide does not *induce* a [Fas/APO-1] activation or apoptosis . Positive_regulation FAS TP53 10660538 664478 Contrary to bax , another known pro-apoptotic p53-target gene , both mouse and human [FAS] p53REs are still *activated* by the discriminatory mutants Pro-175 and Ala-143 , a class of mutants unable to induce apoptosis . Positive_regulation FAS TP53 10660538 664479 We propose that *dependent* up-regulation of [Fas] does not induce apoptosis per se but sensitizes the cell to other pro-apoptotic signal ( s ) . Positive_regulation FAS TP53 10660538 664482 The functional conservation of *dependent* [Fas] up-regulation argues strongly in favor of its biological importance and suggests that murine models may be used to study further the in vivo role of Fas in the p53 response . Positive_regulation FAS TP53 10969818 728477 We hypothesize that oncogenic activation and DNA damage are sufficient stimuli to increase the *dependent* transcription of [Fas] and thereby establish a situation in which cell to cell contact could be a selective pressure to either lose p53 function or inactivate components of the Fas death pathway . Positive_regulation FAS TP53 11692157 876421 Experimental data have shown *dependent* [CD95] induction to be associated with increased levels of apoptosis after cytostatic treatment in hepatoma cells . Positive_regulation FAS TP53 11793363 901978 However , the *role* of wild-type in [Fas] expression is still controversial . Positive_regulation FAS TP53 11803462 903020 We show that , subsequent to sequestration and inactivation of the p53 tumour suppressor protein , SV40 abrogates *dependent* , DNA damage-inducible up-regulation of [CD95] surface expression . Positive_regulation FAS TP53 11870542 918467 Induction of wild type *enhanced* the expression levels of Bax , p21/WAF1 , and [Fas] protein . Positive_regulation FAS TP53 11870542 918472 This suggests that induction of wild type *upregulates* [Fas] , which in turn may play a role in the activation of Apaf-1 and caspase-9 . Positive_regulation FAS TP53 11967210 933114 [Fas] is involved in the *dependent* apoptotic response to ionizing radiation in mouse testis . Positive_regulation FAS TP53 12424791 1014236 Hepatocytes that were immunoreactive for p53 had slightly increased with aging , suggesting that may *mediate* the age enhanced up-regulation of [Fas] receptor in hepatocytes . Positive_regulation FAS TP53 12480919 1024259 [Fas] ligation *induces* apoptosis of lung epithelial cells predominantly through the direct activation of the caspase cascade via caspase-8 activation , whereas the up-regulation of and other cellular stresses can induce mitochondria mediated apoptosis . Positive_regulation FAS TP53 14676844 1202516 We found that *induced* the expression of the proapoptotic genes PUMA , Bak , Bax , and [Fas] in a cell type- and time dependent manner . Positive_regulation FAS TP53 14719118 1197727 Use of the protein transport inhibitor Brefeldin A significantly inhibited *induced* surface [Fas/CD95] expression , but only partially inhibited apoptosis in mutant-p53 cell lines . Positive_regulation FAS TP53 14719118 1197728 These results suggest that *regulates* [Fas/CD95] expression at the transcriptional level and through protein trafficking in mutant-p53 cell lines . Positive_regulation FAS TP53 15207713 1261652 The finding that Adp14ARF infection did not induce Fas expression in U2OS/E6 and MCF/E6 cells suggests that wild type expression may be *necessary* for Adp14ARF mediated induction of [Fas] . Positive_regulation FAS TP53 15661885 1365102 Our data indicate that BM depletion in acute GVHD is mediated by *dependent* up-regulation of [Fas] on BMC , which leads to Fas dependent depletion and subsequent disease . Positive_regulation FAS TP53 16317104 1526231 Epstein-Barr virus ( EBV ) induces CD95 expression and the [CD95] gene ( FAS ) is *regulated* by NF-kappaB , STAT1 , and/or . Positive_regulation FAS TP53 16432159 1516246 *induced* a 3-fold increase in extracellular membrane [Fas] expression in glioma cells but no significant increase in nonmalignant glial cells . Positive_regulation FAS TP53 17283151 1698218 Conversely , inhibition of using antisense oligonucleotide in A549 *caused* a significant decrease in apoptosis by gefitinib and down-regulation of [Fas] under the same conditions . Positive_regulation FAS TP53 20597837 2309417 However , when we introduced p53 into H1299 cells , siDcr3 ( siRNA of Dcr3 ) suppressed the radioresistance of H1299 cells by inducing *dependent* [Fas] ( Fas receptor , also known as TNFRSF6 ; Positive_regulation FAS TP53 21364648 2361020 The delayed induction was controlled by a *dependent* transcription step and the production of death receptors ( especially [CD95/Fas] ) . Positive_regulation FAS TP53 21509038 2418639 More specifically , our results indicate that *dependent* induction of Fas membrane expression ( ~threefold ) and enhanced [Fas/FasL] interactions at the cell surface are important mechanisms of Nutlin-3 induced apoptosis in TC cells . Positive_regulation FAS TP53 21616517 2441812 Our results indicated that the level of protein and mRNA increased significantly , and p53 *activated* the expression of its downstream pro-apoptosis gene PUMA , Bax and [Fas] in the S180 and H-22 cells . Positive_regulation FAS TP53 24622841 2930156 *dependent* [Fas] expression is critical for Ginsenoside Rh2 triggered caspase-8 activation in HeLa cells . Positive_regulation FAS TP53 9022073 413238 Bleomycin did not *increase* [CD95] in hepatoma cells with mutated ( Huh7 ) or in hepatoma cells which were p53-/- ( Hep3B ) . Positive_regulation FAS TP53 9395128 468299 Experimentally , apoptosis is preceded by nuclear accumulation of , and *increased* expression of [Fas] ( CD95 ) antigen . Positive_regulation FAS TP53 9398058 468949 Interestingly , accumulation of was *followed* by up-regulation of surface [Fas] levels between 4 and 8 hr after irradiation . Positive_regulation FAS TP53 9398058 468950 These findings demonstrate a direct correlation between wild-type-p53 activity and Fas up-regulation after treatment with ionizing radiation , strongly suggesting that post-irradiation [Fas] up-regulation is *dependent* on activity . Positive_regulation FAS TP53 9539784 497982 This suppression of apoptosis by A23187 or TG was associated with suppression of caspase activation but not with suppression of *induced* expression of WAF-1 , mdm-2 , or [FAS] . Positive_regulation FAS TP53 9765154 537457 In human vascular smooth muscle cells , activation transiently *increased* surface [Fas] ( CD95 ) expression by transport from the Golgi complex . Positive_regulation FAS TP53 9765154 537458 Golgi disruption blocked both *induced* surface [Fas] expression and apoptosis . Positive_regulation FAS TP53 9765154 537459 also *induced* [Fas-FADD] binding and transiently sensitized cells to Fas induced apoptosis . Positive_regulation FAS TP53 9841917 552942 In an attempt to understand how [CD95] expression is *regulated* by , we identified a p53-responsive element within the first intron of the CD95 gene , as well as three putative elements within the promoter . Positive_regulation FAS TRAF2 9221764 442625 Studies with human B cells show that the binding of CD154 ( gp39 , CD40L ) to CD40 recruits ( TRAF2 ) and TRAF3 to the receptor complex , induces the downregulation of the nonreceptor associated TRAFs in the cell and *induces* an increased expression of [Fas] on the cell surface . Positive_regulation FAS TRAF3 9221764 442626 Studies with human B cells show that the binding of CD154 ( gp39 , CD40L ) to CD40 recruits TNF receptor- associated factor 2 ( TRAF2 ) and to the receptor complex , induces the downregulation of the nonreceptor associated TRAFs in the cell and *induces* an increased expression of [Fas] on the cell surface . Positive_regulation FAS TRIM26 15849812 1399222 For Jurkat cell line , could suppress the expression of FasL and TRAIL , and *stimulate* the expression of [Fas] and TRAILR . Positive_regulation FAS TRIM26 15849812 1399224 is able to promote the expression of FasL and TRAIL in hepatoma cells and *enhance* the expression of [Fas] and TRAILR in lymphocytes . Positive_regulation FAS USF1 11583420 865611 The present study was conducted to initially evaluate whether there is a somatotropin response element (STRE) in the 5'flanking region of the FAS gene and to determine whether *mediates* the effect of ST on [FAS] gene transcription in 3T3-F442A adipocytes . Positive_regulation FAS USF1 12897158 1118440 We conclude that the FAS promoter is activated during refeeding via the induced binding of SREBP to the -150 SRE and that binding to the -65 E-box is also *required* for SREBP binding and activation of the [FAS] promoter . Positive_regulation FAS USF1 19303849 2052117 The transcription factor is *required* for the activation of [FAS] transcription , and we show here that USF phosphorylation by DNA-PK , which is dephosphorylated by PP1 in response to feeding , triggers a switch-like mechanism . Positive_regulation FAS USF2 12897158 1118441 We conclude that the FAS promoter is activated during refeeding via the induced binding of SREBP to the -150 SRE and that binding to the -65 E-box is also *required* for SREBP binding and activation of the [FAS] promoter . Positive_regulation FAS USF2 17282969 1698164 In the *presence* of , [CD95] expression was upregulated and Bcl-xL and pro-caspase 3 expression were downregulated in cultured eosinophils . Positive_regulation FAS USF2 19303849 2052118 The transcription factor is *required* for the activation of [FAS] transcription , and we show here that USF phosphorylation by DNA-PK , which is dephosphorylated by PP1 in response to feeding , triggers a switch-like mechanism . Positive_regulation FAS VCL 16584805 1562501 Expression of rescued the spreading defect and *resulted* in larger and more stable [FAs] . Positive_regulation FAS WDR61 12709415 1093348 The activated increased the mucosal IL-6 and PECAM-1 , *enhanced* the expression of FasL but not [Fas] , and led to the cleavage of Bid and the release of cytochrome c from mitochondria to activate caspase-9 . Positive_regulation FAS WNK1 11473033 841557 In cotransfection experiments , NF-kappaB *transactivated* the [Fas] promoter . Positive_regulation FAS YY1 16081784 1442833 Inhibition of activity by either rituximab or the NO donor DETANONOate or after transfection with YY1 small interfering RNA *resulted* in up-regulation of [Fas] expression and sensitization to CH-11 induced apoptosis . Positive_regulation FAS YY1 16103877 1488992 Inhibition of *resulted* in the upregulation of [Fas] expression and sensitization of the tumor cells to CH-11 induced apoptosis . Positive_regulation FAS YY1 16143308 1454922 The direct *role* of in the negative regulation of [Fas] expression was demonstrated by transfection of cells with siRNA YY1 . Positive_regulation FAS YY1 16784892 1599410 We have reported that [Fas] expression and sensitivity to FasL is negatively *regulated* by the transcription repressor factor . Positive_regulation FAS YY1 21794413 1847972 Since down *regulates* [Fas] in cancer cell lines , it is reasonable to consider that this transcription factor may control Fas expression in lupus nephritis . Positive_regulation FASLG ANGPT1 15763944 1352565 Interestingly , the DOX induced up-regulation in Fas ( CD95/APO-1 ) and Fas ligand expression could be blocked by Ang-1 , indicating a pivotal *role* of in DOX induced Fas and [Fas ligand] expression . Positive_regulation FASLG CCND1 23975033 2920852 Emodin ( 72 h ) treatment could up-regulate the gene expression of [FASL] ( p < 0.05 ) and down-regulate the gene expression of C-MYC ( p < 0.01 ) , but *induce* no significant changes in the gene expressions of MCL1 , GAPDH , BAX and . Positive_regulation FASLG EPHB2 11279537 764688 dependent cytosolic phospholipase A2 activity is *induced* by [CD95 ligand] cross linking in the mouse derived Sertoli cell line TM4 and is required to trigger apoptosis in CD95 bearing cells . Positive_regulation FASLG EPHB2 14630709 1188072 Fas and [FasL] overexpression was *dependent* on reactive oxygen species ( ROS ) production as well as and JNK activation . Positive_regulation FASLG EPHB2 19201817 2061384 Activation of GPR54 resulted in the *dependent* expression of tumor necrosis factor-alpha and [FasL] in a lymphoid cell line , the latter being the main trigger of apoptosis . Positive_regulation FASLG FAS 10027921 591488 By comparison , we *detected* an increase in [FasL] in MRL-Faslpr kidneys ( 3 to 5 months of age ) , whereas was not detectable . Positive_regulation FASLG FAS 10091108 600324 Virus infected hepatocytes bear receptors and apoptosis is *induced* by binding to the [Fas ligand] which is expressed by activated T cells ; Positive_regulation FASLG FAS 10417181 631583 The expression of Fas and [Fas ligand] was immunohistochemically *detected* on renal tubular epithelial cells from GSR induced mice , although neither nor Fas ligand was found in cells from untreated control mice or in cells from mice receiving a single injection of LPS . Positive_regulation FASLG FAS 10484385 644006 C. parvum stimulated FasL membrane surface translocation , increased both FasL and protein expression in infected biliary epithelia , and *induced* a marked increase of soluble [FasL] ( but not IL-1beta , TNF-alpha , and TGF-beta ) in supernatants from infected cells . Positive_regulation FASLG FAS 10553053 565482 Whereas mature bone marrow- or spleen derived DCs expressed high levels of Fas , these DCs were relatively insensitive to *mediated* killing by the agonist mAb , Jo-2 , as well as authentic [Fas ligand] expressed on the CD4+ T cell line , A.E7 . Positive_regulation FASLG FAS 10579724 569901 Therefore , *activation* of by endogenous [FasL] underlies cell death induced by trophic deprivation . Positive_regulation FASLG FAS 10611305 575509 *Activation* of by [FasL] induces apoptosis by a mechanism that can not be blocked by Bcl-2 or Bcl-x ( L ) . Positive_regulation FASLG FAS 10653388 663202 Soluble anti-CD3epsilon F ( ab ' ) 2 did not regulate or *induce* [FasL] expression , indicating that the ability of anti-CD3epsilon F ( ab ' ) 2 to induce T cell apoptosis depends on a distinct mechanism . Positive_regulation FASLG FAS 10727463 678001 Our data suggest a novel model of T cell AICD in which p38 MAPK acts early to initiate [FasL] expression and the mediated *activation* of caspases . Positive_regulation FASLG FAS 10779162 687130 [Fas ligand] ( FasL , CD95L ) *induces* apoptosis in activated T cells with upregulated ( CD95 ) expression through the process termed activation induced cell death ( AICD ) . Positive_regulation FASLG FAS 10858249 704681 These observations demonstrate that local Th1 cells may contribute to the pathogenesis of gastric disease during H. pylori infection by increasing the expression of on gastric epithelial cells and *inducing* apoptosis through [Fas/FasL] interactions . Positive_regulation FASLG FAS 10861043 705133 Both the *mediated* cytotoxicity and [FasL] expression of cytotoxic allogeneic PELs generated in vivo in the presence of VIP or PACAP were significantly reduced . Positive_regulation FASLG FAS 10899765 712402 [FasL] was detected in infiltrating mononuclear cells , and Fas was *detected* in infiltrating mononuclear cells , alveolar macrophages , and epithelioid cells in HP , whereas FasL was not detected and was detected in few alveolar macrophages in controls . Positive_regulation FASLG FAS 10958304 724864 [Fas ligand (FasL)] *induces* apoptosis of susceptible cells by cross linking its own receptor , . Positive_regulation FASLG FAS 11029528 739864 ii ) stromal mononuclear cells express [Fas ligand] in *response* to expression in carcinoma cells ; Positive_regulation FASLG FAS 11104808 756536 engagement *induces* the maturation of dendritic cells (DCs) , the release of interleukin (IL)-1beta , and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction : a new role for [Fas ligand] in inflammatory responses . Positive_regulation FASLG FAS 11197846 785414 Our previous results showed that rheumatoid synoviocytes expressed [Fas ligand] and were *induced* apoptosis by antibody treatment . Positive_regulation FASLG FAS 11435457 832518 The IL-12/IL-2 combination synergistically enhances cell surface [FasL] expression on CD8 ( + ) T lymphocytes in vitro and *induces* and FasL expression within tumors via an IFN-gamma dependent mechanism in vivo . Positive_regulation FASLG FAS 11729124 884829 Acute liver failure ( ALF ) of viral origin results from massive hepatocyte apoptosis *induced* by the interaction between expressed on hepatocytes and [Fas ligand] on activated T lymphocytes . Positive_regulation FASLG FAS 11888853 920071 The present results demonstrate that GnRHa directly inhibits the growth of human uterine leiomyoma cells by suppressing cell proliferation and inducing apoptosis , which might be associated with the increase in expression and the *induction* of [Fas ligand] expression in the cells . Positive_regulation FASLG FAS 11958821 931304 Results obtained , utilizing real-time quantitative RT-PCR , show that , while a bolus injection of LPS robustly increases hippocampal , but not FasL , mRNA expression , repeated LPS administrations also *induce* [FasL] up-regulation . Positive_regulation FASLG FAS 12037733 949385 [FasL] is a type II membrane protein of the tumor necrosis factor family , and *induces* apoptosis when it binds to . Positive_regulation FASLG FAS 12370548 996034 and Fas ligand (FasL) mediate apoptosis of tumor cells in immune surveillance , and expression of [FasL] by tumors may *mediate* their counterattack on cytotoxic lymphocytes . Positive_regulation FASLG FAS 12393889 1025380 Membrane bound [FasL] *induces* powerful mediated signals because it possesses both Fas focusing and signal transducing functions . Positive_regulation FASLG FAS 12594841 1061074 The binding of sHLA-A , -B , -C and sHLA-G1 molecules to CD8 leads to [Fas ligand (FasL)] *up-regulation* , soluble FasL ( sFasL ) secretion and CD8 ( + ) cell apoptosis by interaction . Positive_regulation FASLG FAS 12818572 1103849 *Activation* of signaling by either recombinant membrane [FasL] under normal culture conditions or H/R causes cardiomyocyte death mainly through the mitochondrial damage/caspase 9 activation pathway . Positive_regulation FASLG FAS 14499341 1143688 *Activation* of receptor by [Fas ligand] causes caspase 8 activation and apoptosis in cells and is an important mechanism by which normal tissue homeostasis and function are maintained . Positive_regulation FASLG FAS 14597220 1160403 [Fas ligand] and TNF-alpha were also *detected* among pancreas infiltrating cells , whereas was rarely expressed in the pancreatic acinar cells . Positive_regulation FASLG FAS 14647441 1176733 FR901228 induces tumor regression associated with induction of [Fas ligand] and *activation* of signaling in human osteosarcoma cells . Positive_regulation FASLG FAS 14738570 1242694 Cultured human coronary artery endothelial cells ( HCAEC ) were exposed to the monoclonal *activating* antibody CH-11 , to purified recombinant human [Fas ligand] , to the Fas neutralizing antibody ZB4 , or to purified recombinant human TNF-alpha . Positive_regulation FASLG FAS 15274324 1276706 These results indicate that may play an important role , not only in development but also progression , and that [FasL] is not always *required* for both development and progression in colorectal carcinomas . Positive_regulation FASLG FAS 16222040 1469319 Apoptosis pathways are activated in the lungs of patients with acute lung injury , in part by *activation* of the membrane death receptor by soluble [Fas ligand] ( sFasL ) , which accumulates in biologically active form at the onset of lung injury . Positive_regulation FASLG FAS 16565865 1574681 T cells expressing a type-2 T helper profile of cytokines ( Th2 cells ) have been demonstrated to play an important role in the initiation and progression of allergic asthma , and it is well known that [Fas ligand (FasL)] *induces* apoptosis when bound to its receptor , . Positive_regulation FASLG FAS 19193734 2054143 The expression of and active caspase-3 was localized in the same cell types as apoptosis occurred , and expression levels of Fas , [FasL] , and active caspase-3 were significantly *increased* compared with controls . Positive_regulation FASLG FAS 19830835 2196051 *Activation* of by recombinant [Fas ligand (FasL)] did not induce apoptosis in murine NPCs in culture . Positive_regulation FASLG FAS 20422450 2274544 Our data suggest that the impairment of the Na ( + ) -K ( + ) -ATPase activity during apoptosis is linked to perturbations in cell Ca ( 2+ ) homeostasis that modulate apoptosis induced by the *activation* of by [FasL] . Positive_regulation FASLG FAS 20828573 2325283 In 3T3-L1 adipocytes , *activation* of by [Fas ligand] decreased insulin stimulated glucose uptake , without affecting cell viability . Positive_regulation FASLG FAS 21035858 2348999 However , high concentrations of IL-2 strongly blocked IL-18 induced NK cell apoptosis through alleviating IL-18 induced [FasL] expression and *activation* of mediated death signaling and increasing anti-apoptosis molecule ( Bcl-X ( L ) ) . Positive_regulation FASLG FAS 22753932 2627264 caIKKß T cells showed increased [Fas ligand] expression and caspase-8 activation , and blocking ligand interactions *enhanced* cell survival . Positive_regulation FASLG FAS 7489709 332293 is a type I membrane protein and its activation by binding of the [Fas ligand] or an agonistic anti-Fas antibody *induces* apoptosis in Fas bearing cells . Positive_regulation FASLG FAS 7530337 291619 We show here that receptor crosslinking induces [Fas ligand] and upregulates Fas , and that the ensuing engagement of by Fas ligand *activates* the cell-death programme . Positive_regulation FASLG FAS 8838700 386604 Because ligation of Fas can result in costimulation of proliferation or the induction of apoptosis in uninfected cells , we evaluated the effect on T cells of activation by monoclonal antibodies ( MAb ) of different specificity from both UB2 and CH11 clones and *activation* by the [Fas ligand (Fas-L)] . Positive_regulation FASLG FAS 9407341 470906 The system mediated death signal *requires* the interaction of [Fas ligand] with Fas on target cells . Positive_regulation FASLG FAS 9461339 475810 Some cytostatic drugs used in chemotherapy kill their target cells by upregulating expression of and *inducing* [Fas ligand] expression in the same cell by different mechanisms . Positive_regulation FASLG FAS 9506704 491451 To investigate the mechanism ( s ) underlying CTL damage to the myocardium through *activation* of the receptor ( Fas/CD95/Apo-1 ) by the [Fas ligand] , we explored the interaction between peritoneal exudate CTLs ( PELs ) , derived from perforin gene-knockout ( P-/- ) mice , and murine ventricular myocytes . Positive_regulation FASLG FAS 9760568 536726 Under these conditions , the T cells co-express Fas ( CD95 ) and [Fas ligand (FasL)] , and engagement of *triggers* apoptotic death of the T cells . Positive_regulation FASLG FAS 9780248 540527 In investigation of CD95 based apoptosis , tRA had no effect on activation dependent induction of on T lymphocytes , but it *inhibited* the induction of [CD95 ligand] expression on anti-CD3 activated T cells . Positive_regulation FASLG FAS 9831564 551492 [Fas ligand] ( CD95L ) inhibits T cell function in immune privileged organs such as the eye and testis , yet in most tissues expression *induces* potent inflammatory responses . Positive_regulation FASLG FOXO1 12560069 1052731 The noticed phosphorylation dependent exclusion of from the nucleus *impaired* the ability of FKHR to activate its target [Fas ligand] promoter containing the FKHR binding motif ( FRE ) in cells treated with estrogen or expressing catalytically active Pak1 . Positive_regulation FASLG FOXO1 17662023 1780448 After nuclear translocation of NFAT and FKHR , both NFAT and *stimulated* expression of [Fas-ligand] by binding to its promoter region . Positive_regulation FASLG FOXO1 19885597 2161173 Activation of transcription factors also *increased* the expression of [FasL] . Positive_regulation FASLG IL1B 11500835 847108 We previously demonstrated that uncleavable membrane bound [FasL] of mice *induces* release from inflammatory cells , and suggested that the IL-1 beta enhances neutrophil infiltration . Positive_regulation FASLG IL1B 15491504 1321392 [FasL] signaling *induces* inflammatory apoptosis in epithelial cells and alveolar macrophages , with concomitant and chemokine release , leading to neutrophil infiltration . Positive_regulation FASLG IL1B 15897153 1408559 activation *enhanced* the expression of death protein [FasL] in astrocytes , suggesting that FasL is one of the potential factors responsible for neurotoxicity observed in HAD and other CNS diseases involving glial inflammation . Positive_regulation FASLG MMP28 10533808 562457 Recently , we have reported that [FasL] is processed to a soluble form by an unknown metalloproteinase at the cell surface and some hydroxamate inhibitors *inhibit* the processing similar to the case observed with TNF-1alpha . Positive_regulation FASLG MMP7 10533808 562472 Recently , we have reported that [FasL] is processed to a soluble form by an unknown metalloproteinase at the cell surface and some hydroxamate inhibitors *inhibit* the processing similar to the case observed with TNF-1alpha . Positive_regulation FASLG MMP7 11212252 785782 *mediated* cleavage of [Fas ligand] protects tumor cells from chemotherapeutic drug cytotoxicity . Positive_regulation FASLG MMP7 15480896 1320319 and ( 3 ) *mediated* release of soluble [FasL] could control the mesangial inflammation . Positive_regulation FASLG TNF 10454352 637736 In the present study , we showed that [Fas-L] expression on AK-5 cells is *regulated* by interferon-gamma (IFN-gamma) and , as injection of antibodies against IFN-gamma downregulated the expression of Fas-L by tumor cells as determined by immunostaining and Northern hybridizations . Positive_regulation FASLG TNF 10544014 563934 Here we show that in addition to interferon-gamma (IFN-gamma) *induces* cell surface expression of functional [FasL] in human HT29 colon and MCF7 breast adenocarcinoma cells that constitutively lack cell surface expression of FasL . Positive_regulation FASLG TNF 10544178 563985 In contrast , did not *induce* the expression of [FasL] on LEC-1 . Positive_regulation FASLG TNF 11408858 826128 Neither lipopolysaccharide nor *induced* [Fas ligand] expression in human fetal membranes . Positive_regulation FASLG TNF 11549697 856864 Thus , in the seminiferous tubules , germ cell derived may *regulate* the level of the [Fas ligand] and thereby control physiological germ cell apoptosis . Positive_regulation FASLG TNF 11870083 918407 Furthermore , shrunken nuclei and apoptotic bodies were observed in the cells treated with [Fas L] in the *presence* of and IFN . Positive_regulation FASLG TNF 12196549 997901 *induced* activation of the [Fas-ligand] promoter in IEC requires NF-kappaB as this was blocked by an I-kappaBalphaM super-repressor and by mutation of an NF-kappaB site in the Fas-ligand promoter . Positive_regulation FASLG TNF 12391181 1007230 In contrast , IL-12 induced FasL transcription to lead to FasL expression on the surfaces of nonadherent bone marrow cells , whereas could not *induce* [FasL] on the cells . Positive_regulation FASLG TNF 16875741 1613664 Furthermore , IL-18 and IL-12 synergistically induced apoptosis of adherent bone marrow cells in the *presence* of , and up-regulated [FasL] transcription in non-adherent cells . Positive_regulation FASLG TNF 17159605 1678912 The [Fas-Fas ligand] interaction between macrophages and L929 cells *increased* the expression of Fas associated death domain , and tumor necrosis factor-tumor necrosis factor receptor 1 interaction between macrophages and L929 cells increased the expression of receptor associated death domain in L929 cells . Positive_regulation FASLG TNF 18047930 1846652 CMV enhanced development of CAN was associated with tubular apoptosis and concomitant increase of , rather than the [FAS-FAS-ligand] *activation* . Positive_regulation FASLG TNF 19400895 2089518 IFN-gamma and *up-regulated* TNFR1 , TNFR2 , Fas and membrane [FasL] on SMC . Positive_regulation FASLG TNF 19651258 2138484 We previously reported that IL-12 induces apoptosis in bone marrow cells treated with TNF-alpha in vitro via an interaction between *induced* Fas and IL-12 induced [Fas ligand (FasL)] , and that , as a result , osteoclastogenesis is inhibited . Positive_regulation FASLG TNF 19651258 2138495 These results suggest that IL-12 inhibits TNF-alpha mediated osteoclastogenesis and induces apoptotic changes through an interaction between *induced* Fas and IL-12 induced [FasL] , in vivo , via a T cell independent mechanism . Positive_regulation FASLG TNF 21611811 2441802 We have reported that IL-12 and IL-18 induce apoptosis in bone marrow cells treated with TNF-a in vitro and that osteoclastogenesis is inhibited by the interaction of *induced* Fas and the IL-12 induced [Fas ligand (FasL)] . Positive_regulation FASLG TNF 22492973 2613137 In late CL cells , and TNF+IFNG+FASL reduced VEGFR2 mRNA , but [TNF+IFNG+FASL] *increased* TSP1 and CD36 mRNA . Positive_regulation FASLG TNF 9164947 432147 We also show that the killing of Ag-presenting , sensitive cells is mediated by Fas ligand and as well as perforin , although the latter plays a major role in the killing at a low E : T ratio , and that the killing of sensitive bystander cells is primarily *mediated* by [Fas ligand] and TNF-alpha on CTLs expressed upon specific Ag stimulation , which may be relevant to the bystander lysis by HCV-specific CTLs of uninfected hepatocytes , in which Fas expression is up-regulated . Positive_regulation FASLG TNF 9378984 465718 The in vivo administration of anti-IL-18 just before an LPS challenge suppressed not only the induction of IFN-gamma and the late elevation , but also the [FasL] *induction* , resulting in the total prevention of liver injury , whereas such an anti-IL-12 treatment did not . Positive_regulation FASLG TNFSF10 16037714 1437325 [Fas ligand] and *induction* on infiltrating lymphocytes in bladder carcinoma by bacillus Calmette-Guérin treatment . Positive_regulation FASN FOXO1 16997836 1640801 Increased activity *resulted* in up-regulation of hepatic peroxisome proliferator activated receptor-gamma coactivator-1beta , [fatty acid synthase] , and acetyl CoA carboxylase expression , accounting for increased hepatic fat infiltration . Positive_regulation FASN TNF 20606731 2286349 In vitro incubation of primary human hepatocytes with fatty acids dose-dependently *induced* cellular lipid-accumulation and [FASN] expression , while stimulation with did not affect FASN levels . Positive_regulation FAT1 TNF 22025632 2508056 Here , we show that *induces* [FAT10] gene expression through TNF receptor 1 (TNFR1) and activates the NF-?B pathway in HCT116 and SW620 cells . Positive_regulation FBXO32 AKT1 18346979 1919676 Constitutive activation of negatively *regulates* DOX mediated [atrogin-1] induction by inhibiting p38-MAPK activity as a novel mechanism . Positive_regulation FBXO32 AKT1 20966391 2354182 Moreover , inhibition of signaling *attenuated* the phosphorylation of forkhead box O transcription factor ( FOXO)-3a and enhanced [atrogin-1] expression , which in turn suppressed BK-ß ( 1 ) protein levels in human CASMCs . Positive_regulation FBXO32 AKT2 18346979 1919677 Constitutive activation of negatively *regulates* DOX mediated [atrogin-1] induction by inhibiting p38-MAPK activity as a novel mechanism . Positive_regulation FBXO32 AKT2 20966391 2354183 Moreover , inhibition of signaling *attenuated* the phosphorylation of forkhead box O transcription factor ( FOXO)-3a and enhanced [atrogin-1] expression , which in turn suppressed BK-ß ( 1 ) protein levels in human CASMCs . Positive_regulation FBXO32 AKT3 18346979 1919678 Constitutive activation of negatively *regulates* DOX mediated [atrogin-1] induction by inhibiting p38-MAPK activity as a novel mechanism . Positive_regulation FBXO32 AKT3 20966391 2354184 Moreover , inhibition of signaling *attenuated* the phosphorylation of forkhead box O transcription factor ( FOXO)-3a and enhanced [atrogin-1] expression , which in turn suppressed BK-ß ( 1 ) protein levels in human CASMCs . Positive_regulation FBXO32 CASQ1 24243720 2897995 Ectopic expression of in C2C12 myoblast *resulted* in decreased activity of nuclear factor of activated T-cells and increased levels of [atrogin-1] and MuRF1 E3 ligase , suggesting that these differentially expressed proteins are involved in muscle aging . Positive_regulation FBXO32 CASQ2 24243720 2897996 Ectopic expression of in C2C12 myoblast *resulted* in decreased activity of nuclear factor of activated T-cells and increased levels of [atrogin-1] and MuRF1 E3 ligase , suggesting that these differentially expressed proteins are involved in muscle aging . Positive_regulation FBXO32 CBL 19546233 2116778 Furthermore , a pentapeptide mimetic of tyrosine ( 608 ) -phosphorylated IRS-1 inhibited Cbl-b mediated IRS-1 ubiquitination and strongly decreased the *mediated* induction of [atrogin-1/MAFbx] . Positive_regulation FBXO32 CBL 23187081 2704717 This Cblin peptide inhibited Cbl-b mediated IRS-1 ubiquitination and strongly decreased the *mediated* induction of [MAFbx/atrogin-1] . Positive_regulation FBXO32 EEF1A2 19406843 2128178 Further , inhibitors of the transfer of geranylgeranyl isoprene units to protein targets cause muscle damage and [atrogin-1] *induction* in cultured cells and in fish . Positive_regulation FBXO32 FOXO1 15125842 1244683 a mutant form of , which prevents Akt phosphorylation , thereby *prevents* Akt mediated inhibition of MuRF1 and [MAFbx] upregulation . Positive_regulation FBXO32 FOXO1 19553561 2128955 activation *resulted* in a significant increase in [muscle atrophy F-box (MAFbx)/atrogin-1] , muscle-specific RING finger protein 1 ( MuRF-1 ) , and Bcl-2 interacting mediator of cell death ( Bim ) gene expression , with no significant increase in Bcl-2/adenovirus E1B 19-kDa interacting protein 3 ( BNip3 ) gene expression . Positive_regulation FBXO32 FOXO1 20079455 2218697 Results suggest that sepsis increases FOXO1 expression and activity in skeletal muscle by a glucocorticoid dependent mechanism and that glucocorticoid dependent upregulation of [atrogin-1] and MuRF1 in skeletal muscle is *regulated* by . Positive_regulation FBXO32 FOXO1 20371624 2293873 The PI3K/Akt pathway inhibits the *mediated* transcription of the muscle-specific E3 ligase [atrogin-1/MAFbx (AT-1)] , whereas the MEK/ERK pathway increases Sp1 activity and ubiquitin ( UbC ) expression . Positive_regulation FBXO32 FOXO3 17053067 1642013 FoxO family transcription factors play a critical role in this loss of cell protein , and when activated , *causes* expression of the atrophy related ubiquitin ligases [atrogin-1] and MuRF-1 and profound loss of muscle mass . Positive_regulation FBXO32 FOXO3 18644837 1979355 Indeed , we show that specific inhibition of *prevented* the increases in both [atrogin-1] and MuRF1 promoter activities during disuse . Positive_regulation FBXO32 FOXO3 19546233 2116776 In turn , the loss of IRS-1 activated the *dependent* induction of [atrogin-1/MAFbx] , a dominant mediator of proteolysis in atrophic muscle . Positive_regulation FBXO32 FOXO3 20371624 2293874 The PI3K/Akt pathway inhibits the *mediated* transcription of the muscle-specific E3 ligase [atrogin-1/MAFbx (AT-1)] , whereas the MEK/ERK pathway increases Sp1 activity and ubiquitin ( UbC ) expression . Positive_regulation FBXO32 FOXO3 22590725 2598970 Aßi reduces levels of p-Akt and downstream p-Foxo3A , resulting in translocation and [Atrogin-1] *induction* . Positive_regulation FBXO32 FOXO4 20371624 2293875 The PI3K/Akt pathway inhibits the *mediated* transcription of the muscle-specific E3 ligase [atrogin-1/MAFbx (AT-1)] , whereas the MEK/ERK pathway increases Sp1 activity and ubiquitin ( UbC ) expression . Positive_regulation FBXO32 FOXO6 20371624 2293872 The PI3K/Akt pathway inhibits the *mediated* transcription of the muscle-specific E3 ligase [atrogin-1/MAFbx (AT-1)] , whereas the MEK/ERK pathway increases Sp1 activity and ubiquitin ( UbC ) expression . Positive_regulation FBXO32 GHSR 18191156 1870217 The suppressive effect on the expressions of [Atrogin-1] and MuRF1 by GHRP-2 was *blocked* by [ D-Lys ( 3 ) ] <-GHRP-6> , a GHS-R1a blocker , suggesting the effect of GHRP-2 was mediated through GHS-R1a . Positive_regulation FBXO32 GRAP2 17131360 1700751 These results indicate that curcumin is effective in blocking LPS induced loss of muscle mass through the inhibition of *mediated* upregulation of [atrogin-1/MAFbx] . Positive_regulation FBXO32 IGF1 15100091 1288137 *stimulates* muscle growth by suppressing protein breakdown and expression of atrophy related ubiquitin ligases , [atrogin-1] and MuRF1 . Positive_regulation FBXO32 IGF1 15100091 1288139 activates the phosphatidylinositol 3-kinase (PI3K)-Akt pathway , and inhibition of this pathway [ but not the calcineurin-nuclear factor of activated T cell ( NFAT ) or the MEK-ERK pathway ] *increased* proteolysis and [atrogin-1] mRNA expression . Positive_regulation FBXO32 IL1A 19625606 2131255 We conclude that and IL-1beta act via an oxidant- and AKT/Foxo independent mechanism to activate p38 MAPK , *stimulate* NF-kappaB signaling , increase expression of [atrogin1/MAFbx] and MuRF1 , and reduce myofibrillar protein in differentiated myotubes . Positive_regulation FBXO32 IL1B 19625606 2131256 We conclude that IL-1alpha and act via an oxidant- and AKT/Foxo independent mechanism to activate p38 MAPK , *stimulate* NF-kappaB signaling , increase expression of [atrogin1/MAFbx] and MuRF1 , and reduce myofibrillar protein in differentiated myotubes . Positive_regulation FBXO32 IL6 18712412 2028244 Muscle wasting and *induced* [atrogin-I] expression in the cachectic Apc ( Min/+ ) mouse . Positive_regulation FBXO32 INS 17418104 1728687 and amino acid availability *regulate* [atrogin-1] in avian QT6 cells . Positive_regulation FBXO32 INS 17418104 1728689 In conclusion , expression of the ubiquitin ligase [atrogin-1] is *regulated* by both and amino acids through the TOR pathway . Positive_regulation FBXO32 INS 21917898 2479542 SIV infection induced an inflammatory and pro-oxidative milieu in skeletal muscle , which was associated with decreased *stimulated* phosphatidylinositol 3-kinase (PI-3k) activity and upregulated gene expression of mTOR and [atrogin-1] , and protein expression of Ub-proteasome system 19S base . Positive_regulation FBXO32 MAPK1 17131360 1700739 In addition , we recently found that p38 *mediates* TNF-alpha upregulation of [atrogin-1/MAFbx] expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation FBXO32 MAPK1 20826541 2368424 TLR4 mediated activation of p38 is necessary and *sufficient* for the up-regulation of [atrogin1/MAFbx] and autophagosomes , resulting in myotube atrophy . Positive_regulation FBXO32 MAPK1 23046544 2710494 p38ß *upregulates* [atrogin1/MAFbx] by specific phosphorylation of C/EBPß . Positive_regulation FBXO32 MAPK10 17131360 1700740 In addition , we recently found that p38 *mediates* TNF-alpha upregulation of [atrogin-1/MAFbx] expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation FBXO32 MAPK10 20826541 2368425 TLR4 mediated activation of p38 is necessary and *sufficient* for the up-regulation of [atrogin1/MAFbx] and autophagosomes , resulting in myotube atrophy . Positive_regulation FBXO32 MAPK10 23046544 2710495 p38ß *upregulates* [atrogin1/MAFbx] by specific phosphorylation of C/EBPß . Positive_regulation FBXO32 MAPK11 17131360 1700741 In addition , we recently found that p38 *mediates* TNF-alpha upregulation of [atrogin-1/MAFbx] expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation FBXO32 MAPK11 20826541 2368426 TLR4 mediated activation of p38 is necessary and *sufficient* for the up-regulation of [atrogin1/MAFbx] and autophagosomes , resulting in myotube atrophy . Positive_regulation FBXO32 MAPK11 23046544 2710496 p38ß *upregulates* [atrogin1/MAFbx] by specific phosphorylation of C/EBPß . Positive_regulation FBXO32 MAPK12 17131360 1700742 In addition , we recently found that p38 *mediates* TNF-alpha upregulation of [atrogin-1/MAFbx] expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation FBXO32 MAPK12 20826541 2368427 TLR4 mediated activation of p38 is necessary and *sufficient* for the up-regulation of [atrogin1/MAFbx] and autophagosomes , resulting in myotube atrophy . Positive_regulation FBXO32 MAPK12 23046544 2710497 p38ß *upregulates* [atrogin1/MAFbx] by specific phosphorylation of C/EBPß . Positive_regulation FBXO32 MAPK13 17131360 1700743 In addition , we recently found that p38 *mediates* TNF-alpha upregulation of [atrogin-1/MAFbx] expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation FBXO32 MAPK13 20826541 2368428 TLR4 mediated activation of p38 is necessary and *sufficient* for the up-regulation of [atrogin1/MAFbx] and autophagosomes , resulting in myotube atrophy . Positive_regulation FBXO32 MAPK13 23046544 2710498 p38ß *upregulates* [atrogin1/MAFbx] by specific phosphorylation of C/EBPß . Positive_regulation FBXO32 MAPK14 17131360 1700744 In addition , we recently found that p38 *mediates* TNF-alpha upregulation of [atrogin-1/MAFbx] expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation FBXO32 MAPK14 20826541 2368429 TLR4 mediated activation of p38 is necessary and *sufficient* for the up-regulation of [atrogin1/MAFbx] and autophagosomes , resulting in myotube atrophy . Positive_regulation FBXO32 MAPK14 23046544 2710499 p38ß *upregulates* [atrogin1/MAFbx] by specific phosphorylation of C/EBPß . Positive_regulation FBXO32 MAPK15 17131360 1700738 In addition , we recently found that p38 *mediates* TNF-alpha upregulation of [atrogin-1/MAFbx] expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation FBXO32 MAPK15 20826541 2368423 TLR4 mediated activation of p38 is necessary and *sufficient* for the up-regulation of [atrogin1/MAFbx] and autophagosomes , resulting in myotube atrophy . Positive_regulation FBXO32 MAPK15 23046544 2710493 p38ß *upregulates* [atrogin1/MAFbx] by specific phosphorylation of C/EBPß . Positive_regulation FBXO32 MAPK3 17131360 1700745 In addition , we recently found that p38 *mediates* TNF-alpha upregulation of [atrogin-1/MAFbx] expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation FBXO32 MAPK3 20826541 2368430 TLR4 mediated activation of p38 is necessary and *sufficient* for the up-regulation of [atrogin1/MAFbx] and autophagosomes , resulting in myotube atrophy . Positive_regulation FBXO32 MAPK3 23046544 2710500 p38ß *upregulates* [atrogin1/MAFbx] by specific phosphorylation of C/EBPß . Positive_regulation FBXO32 MAPK4 17131360 1700746 In addition , we recently found that p38 *mediates* TNF-alpha upregulation of [atrogin-1/MAFbx] expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation FBXO32 MAPK4 20826541 2368431 TLR4 mediated activation of p38 is necessary and *sufficient* for the up-regulation of [atrogin1/MAFbx] and autophagosomes , resulting in myotube atrophy . Positive_regulation FBXO32 MAPK4 23046544 2710501 p38ß *upregulates* [atrogin1/MAFbx] by specific phosphorylation of C/EBPß . Positive_regulation FBXO32 MAPK6 17131360 1700747 In addition , we recently found that p38 *mediates* TNF-alpha upregulation of [atrogin-1/MAFbx] expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation FBXO32 MAPK6 20826541 2368432 TLR4 mediated activation of p38 is necessary and *sufficient* for the up-regulation of [atrogin1/MAFbx] and autophagosomes , resulting in myotube atrophy . Positive_regulation FBXO32 MAPK6 23046544 2710502 p38ß *upregulates* [atrogin1/MAFbx] by specific phosphorylation of C/EBPß . Positive_regulation FBXO32 MAPK7 17131360 1700748 In addition , we recently found that p38 *mediates* TNF-alpha upregulation of [atrogin-1/MAFbx] expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation FBXO32 MAPK7 20826541 2368433 TLR4 mediated activation of p38 is necessary and *sufficient* for the up-regulation of [atrogin1/MAFbx] and autophagosomes , resulting in myotube atrophy . Positive_regulation FBXO32 MAPK7 23046544 2710503 p38ß *upregulates* [atrogin1/MAFbx] by specific phosphorylation of C/EBPß . Positive_regulation FBXO32 MAPK8 17131360 1700749 In addition , we recently found that p38 *mediates* TNF-alpha upregulation of [atrogin-1/MAFbx] expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation FBXO32 MAPK8 20826541 2368434 TLR4 mediated activation of p38 is necessary and *sufficient* for the up-regulation of [atrogin1/MAFbx] and autophagosomes , resulting in myotube atrophy . Positive_regulation FBXO32 MAPK8 23046544 2710504 p38ß *upregulates* [atrogin1/MAFbx] by specific phosphorylation of C/EBPß . Positive_regulation FBXO32 MAPK9 17131360 1700750 In addition , we recently found that p38 *mediates* TNF-alpha upregulation of [atrogin-1/MAFbx] expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation FBXO32 MAPK9 20826541 2368435 TLR4 mediated activation of p38 is necessary and *sufficient* for the up-regulation of [atrogin1/MAFbx] and autophagosomes , resulting in myotube atrophy . Positive_regulation FBXO32 MAPK9 23046544 2710505 p38ß *upregulates* [atrogin1/MAFbx] by specific phosphorylation of C/EBPß . Positive_regulation FBXO32 MSTN 18542002 1923579 Molecular analyses reveal that excess levels of *induce* [Atrogin-1] expression by reducing Akt phosphorylation and thereby increasing FoxO1 activity . Positive_regulation FBXO32 MSTN 21964591 2497822 However , the exact signaling mechanisms by which *regulates* the expression of [Atrogin-1] and MuRF1 , as well as the proteins targeted for degradation in response to excess myostatin , remain to be elucidated . Positive_regulation FBXO32 MSTN 24002653 2856134 Myostatin signaling activates the transcription factor Smad3 ( Small Mothers Against Decapentaplegic ) , which has been shown to be necessary for *induced* [atrogin-1] expression and atrophy ; Positive_regulation FBXO32 MYH2 24453411 2884395 Overall , these results suggest cooperation between cytokines in the reduction of protein expression level via NF-?B/JAK/STAT signaling pathways and *activation* of [Atrogin1] and MuRF1 genes as their molecular targets . Positive_regulation FBXO32 PGC 20647557 2322085 In additional experiments , adenoviral gene transfer of into cultured C2C12 myotubes *resulted* in a dose dependent decrease in [atrogin-1] and MuRF1 mRNA levels . Positive_regulation FBXO32 POLDIP2 23046544 2710507 A C/EBPß mutant in which Thr-188 was replaced by alanine acted as a dominant negative inhibitor of [atrogin1/MAFbx] upregulation *induced* by either or Lewis lung carcinoma ( LLC ) cell conditioned medium ( LCM ) . Positive_regulation FBXO32 PPARGC1A 19837877 2165172 The suppressive effect of beta ( 2 ) -agonist on [atrogin-1] was not *mediated* by ( peroxisome proliferator activated receptor-gamma coactivator 1alpha known to be induced by beta ( 2 ) -agonists and previously shown to inhibit atrogin-1 expression ) , because food deprived PGC-1alpha knockout mice were still sensitive to clenbuterol . Positive_regulation FBXO32 PRKAA1 17264220 1747266 Both [MAFbx] and MuRF1 mRNA increased dose dependently in *response* to these activators . Positive_regulation FBXO32 PRKAA1 17264220 1747278 Stimulation of activity in vivo via AICAR injection *increased* both [MAFbx] and MuRF1 mRNA in murine skeletal muscle . Positive_regulation FBXO32 PRKAA1 21921267 2497241 Nutrient deprivation and pharmacological or genetic activation of *increased* mRNA expression and protein levels of [Atrogin-1] and MuRF1 and consequently enhanced protein degradation in neonatal cardiomyocytes . Positive_regulation FBXO32 PRKAA1 21921267 2497272 *regulates* the transcription of [Atrogin-1] and MuRF1 and enhances UPS mediated protein degradation in heart . Positive_regulation FBXO32 PRKAA2 17264220 1747267 Both [MAFbx] and MuRF1 mRNA increased dose dependently in *response* to these activators . Positive_regulation FBXO32 PRKAA2 17264220 1747279 Stimulation of activity in vivo via AICAR injection *increased* both [MAFbx] and MuRF1 mRNA in murine skeletal muscle . Positive_regulation FBXO32 PRKAA2 21921267 2497242 Nutrient deprivation and pharmacological or genetic activation of *increased* mRNA expression and protein levels of [Atrogin-1] and MuRF1 and consequently enhanced protein degradation in neonatal cardiomyocytes . Positive_regulation FBXO32 PRKAA2 21921267 2497273 *regulates* the transcription of [Atrogin-1] and MuRF1 and enhances UPS mediated protein degradation in heart . Positive_regulation FBXO32 PRKAB1 17264220 1747268 Both [MAFbx] and MuRF1 mRNA increased dose dependently in *response* to these activators . Positive_regulation FBXO32 PRKAB1 17264220 1747280 Stimulation of activity in vivo via AICAR injection *increased* both [MAFbx] and MuRF1 mRNA in murine skeletal muscle . Positive_regulation FBXO32 PRKAB1 21921267 2497243 Nutrient deprivation and pharmacological or genetic activation of *increased* mRNA expression and protein levels of [Atrogin-1] and MuRF1 and consequently enhanced protein degradation in neonatal cardiomyocytes . Positive_regulation FBXO32 PRKAB1 21921267 2497274 *regulates* the transcription of [Atrogin-1] and MuRF1 and enhances UPS mediated protein degradation in heart . Positive_regulation FBXO32 PRKAB2 17264220 1747269 Both [MAFbx] and MuRF1 mRNA increased dose dependently in *response* to these activators . Positive_regulation FBXO32 PRKAB2 17264220 1747281 Stimulation of activity in vivo via AICAR injection *increased* both [MAFbx] and MuRF1 mRNA in murine skeletal muscle . Positive_regulation FBXO32 PRKAB2 21921267 2497244 Nutrient deprivation and pharmacological or genetic activation of *increased* mRNA expression and protein levels of [Atrogin-1] and MuRF1 and consequently enhanced protein degradation in neonatal cardiomyocytes . Positive_regulation FBXO32 PRKAB2 21921267 2497275 *regulates* the transcription of [Atrogin-1] and MuRF1 and enhances UPS mediated protein degradation in heart . Positive_regulation FBXO32 PRKAG1 17264220 1747270 Both [MAFbx] and MuRF1 mRNA increased dose dependently in *response* to these activators . Positive_regulation FBXO32 PRKAG1 17264220 1747282 Stimulation of activity in vivo via AICAR injection *increased* both [MAFbx] and MuRF1 mRNA in murine skeletal muscle . Positive_regulation FBXO32 PRKAG1 21921267 2497245 Nutrient deprivation and pharmacological or genetic activation of *increased* mRNA expression and protein levels of [Atrogin-1] and MuRF1 and consequently enhanced protein degradation in neonatal cardiomyocytes . Positive_regulation FBXO32 PRKAG1 21921267 2497276 *regulates* the transcription of [Atrogin-1] and MuRF1 and enhances UPS mediated protein degradation in heart . Positive_regulation FBXO32 PRKAG2 17264220 1747271 Both [MAFbx] and MuRF1 mRNA increased dose dependently in *response* to these activators . Positive_regulation FBXO32 PRKAG2 17264220 1747283 Stimulation of activity in vivo via AICAR injection *increased* both [MAFbx] and MuRF1 mRNA in murine skeletal muscle . Positive_regulation FBXO32 PRKAG2 21921267 2497246 Nutrient deprivation and pharmacological or genetic activation of *increased* mRNA expression and protein levels of [Atrogin-1] and MuRF1 and consequently enhanced protein degradation in neonatal cardiomyocytes . Positive_regulation FBXO32 PRKAG2 21921267 2497277 *regulates* the transcription of [Atrogin-1] and MuRF1 and enhances UPS mediated protein degradation in heart . Positive_regulation FBXO32 PTGS2 23388481 2713085 These data suggest that inhibition by meloxicam administration can *prevent* the increase in [atrogin-1] and the decrease in MyoD induced by LPS administration . Positive_regulation FBXO32 SMAD3 21964591 2497827 Based on presented data we propose a model whereby myostatin induces skeletal muscle wasting through targeting sarcomeric proteins via *mediated* up-regulation of [Atrogin-1] and forkhead box O1 . Positive_regulation FBXO32 SMAD3 24002653 2856132 *induces* [atrogin-1] , inhibits mTOR and protein synthesis , and promotes muscle atrophy in vivo . Positive_regulation FBXO32 SMAD3 24002653 2856154 To accomplish this goal , in vivo transfection of plasmid DNA was used to create transient transgenic mouse skeletal muscles , and our results show for the first time that expression is *sufficient* to stimulate [atrogin-1] promoter activity , inhibit Akt/mTOR signaling and protein synthesis , and induce muscle fiber atrophy . Positive_regulation FBXO32 STAT1 24453411 2884392 TNF- a and IFN-s dependent muscle decay is linked to NF-?B- and *stimulated* [Atrogin1] and MuRF1 genes in C2C12 myotubes . Positive_regulation FBXO32 TCF12 18367868 1898777 FoxO3 causes marked atrophy in adult skeletal muscle and *induces* the muscle-specific ubiquitin ligase [Atrogin-1/MAFbx.] ( 1 ) In addition , we recently reported that FoxO3 is necessary and sufficient for the induction of autophagy in skeletal muscle . Positive_regulation FBXO32 TCF15 18367868 1898778 FoxO3 causes marked atrophy in adult skeletal muscle and *induces* the muscle-specific ubiquitin ligase [Atrogin-1/MAFbx.] ( 1 ) In addition , we recently reported that FoxO3 is necessary and sufficient for the induction of autophagy in skeletal muscle . Positive_regulation FBXO32 TCF19 18367868 1898779 FoxO3 causes marked atrophy in adult skeletal muscle and *induces* the muscle-specific ubiquitin ligase [Atrogin-1/MAFbx.] ( 1 ) In addition , we recently reported that FoxO3 is necessary and sufficient for the induction of autophagy in skeletal muscle . Positive_regulation FBXO32 TCF20 18367868 1898780 FoxO3 causes marked atrophy in adult skeletal muscle and *induces* the muscle-specific ubiquitin ligase [Atrogin-1/MAFbx.] ( 1 ) In addition , we recently reported that FoxO3 is necessary and sufficient for the induction of autophagy in skeletal muscle . Positive_regulation FBXO32 TCF21 18367868 1898781 FoxO3 causes marked atrophy in adult skeletal muscle and *induces* the muscle-specific ubiquitin ligase [Atrogin-1/MAFbx.] ( 1 ) In addition , we recently reported that FoxO3 is necessary and sufficient for the induction of autophagy in skeletal muscle . Positive_regulation FBXO32 TCF23 18367868 1898785 FoxO3 causes marked atrophy in adult skeletal muscle and *induces* the muscle-specific ubiquitin ligase [Atrogin-1/MAFbx.] ( 1 ) In addition , we recently reported that FoxO3 is necessary and sufficient for the induction of autophagy in skeletal muscle . Positive_regulation FBXO32 TCF24 18367868 1898787 FoxO3 causes marked atrophy in adult skeletal muscle and *induces* the muscle-specific ubiquitin ligase [Atrogin-1/MAFbx.] ( 1 ) In addition , we recently reported that FoxO3 is necessary and sufficient for the induction of autophagy in skeletal muscle . Positive_regulation FBXO32 TCF25 18367868 1898786 FoxO3 causes marked atrophy in adult skeletal muscle and *induces* the muscle-specific ubiquitin ligase [Atrogin-1/MAFbx.] ( 1 ) In addition , we recently reported that FoxO3 is necessary and sufficient for the induction of autophagy in skeletal muscle . Positive_regulation FBXO32 TCF3 18367868 1898782 FoxO3 causes marked atrophy in adult skeletal muscle and *induces* the muscle-specific ubiquitin ligase [Atrogin-1/MAFbx.] ( 1 ) In addition , we recently reported that FoxO3 is necessary and sufficient for the induction of autophagy in skeletal muscle . Positive_regulation FBXO32 TCF4 18367868 1898783 FoxO3 causes marked atrophy in adult skeletal muscle and *induces* the muscle-specific ubiquitin ligase [Atrogin-1/MAFbx.] ( 1 ) In addition , we recently reported that FoxO3 is necessary and sufficient for the induction of autophagy in skeletal muscle . Positive_regulation FBXO32 TCF7 18367868 1898784 FoxO3 causes marked atrophy in adult skeletal muscle and *induces* the muscle-specific ubiquitin ligase [Atrogin-1/MAFbx.] ( 1 ) In addition , we recently reported that FoxO3 is necessary and sufficient for the induction of autophagy in skeletal muscle . Positive_regulation FBXO32 TGFB1 22190307 2531307 *induces* skeletal muscle atrophy and fibrosis through the induction of [atrogin-1] and scleraxis . Positive_regulation FBXO32 TGFB2 22190307 2531308 *induces* skeletal muscle atrophy and fibrosis through the induction of [atrogin-1] and scleraxis . Positive_regulation FBXO32 TGFB3 22190307 2531309 *induces* skeletal muscle atrophy and fibrosis through the induction of [atrogin-1] and scleraxis . Positive_regulation FBXO32 TLR4 20826541 2368422 mediated activation of p38 MAPK is necessary and *sufficient* for the up-regulation of [atrogin1/MAFbx] and autophagosomes , resulting in myotube atrophy . Positive_regulation FBXO32 TNF 15746179 1379279 Since the cytokine tumor necrosis factor-alpha (TNF-alpha) stimulates both reactive oxygen production and general activity of the ubiquitin conjugating pathway , we hypothesized that would also *increase* [atrogin1/MAFbx] gene expression . Positive_regulation FBXO32 TNF 15746179 1379280 The increase in [atrogin1/MAFbx] gene expression *induced* by was not altered significantly by ERK inhibitor PD98059 or the JNK inhibitor SP600125 . Positive_regulation FBXO32 TNFSF12 17314137 1740819 *increased* the ubiquitination of MyHCf and the transcript levels of [atrogin-1] and MuRF1 ubiquitin ligases . Positive_regulation FBXO32 TRIM63 18577697 1953016 [MAFbx] and proteasome C2 subunit proteins declined as insulin *increased* , with expression largely unchanged . Positive_regulation FBXO32 TRNAI1 19850732 2187496 With , muscle atrophy F [box/Atrogin-1] *increased* by 1.8- , 4.1- , and 7.5-fold at days 1 , 3 , and 7 compared with CTL rats . Positive_regulation FCER1A TNF 19582151 2105068 and , IL-4 *enhanced* the [FcepsilonRI-alpha] protein expression compared to the unstimulated control at 24 , 72 hrs after stimulation . Positive_regulation FCER2 ADRB2 7686438 222140 stimulation *augments* the IL-4 induced [CD23] expression and release and the expression of differentiation markers ( CD14 , CD18 ) by the human monocytic cell line , U 937 . Positive_regulation FCER2 CD14 7533818 296873 Retinoic acid ( RA ) and 1,25- ( OH ) 2-vitamin D3 ( 1,25-D3 ) induced U937 cell maturation into distinct monocytic phenotypes , as demonstrated by *up-regulation* of [CD23] by RA and by 1,25-D3 . Positive_regulation FCER2 CHI3L1 14511234 1146562 Flow cytometry analysis demonstrated that *increased* the expression levels of major histocompatibility complex II , [CD23] , and CD80 , in Raji human B-cell lymphoma similarly to an antibody against CD40 . Positive_regulation FCER2 IL1B 11500085 846946 Cell surface stimulation of [CD23] expressed by astrocytes *induced* production of nitric oxide ( NO ) and which was inhibited by a specific inducible NO-synthase (iNOS) inhibitor ( aminoguanidine ) , indicating the implication of this receptor in the astrocyte inflammatory reaction . Positive_regulation FCER2 TNF 1707698 155074 However , G-CSF and did not *induce* the expression of [Fc epsilon RII] and EO-1 antigen . Positive_regulation FCER2 TNF 19805542 2159645 [CD23] activation also *induced* production from MDM . Positive_regulation FCER2 TNF 2142456 137521 Of several cytokines tested [interleukin (IL) 1 to IL 6 , interferon-gamma (IFN-gamma) , ] only IL 4 and IFN-gamma significantly modified allergen *induced* [Fc epsilon RII/CD23] expression on T cells . Positive_regulation FCER2 TNF 7522713 272117 In the present study , we showed that the ligation of [CD23] by IgE/anti-IgE immune complexes or specific monoclonal antibody , *induces* a dose dependent release of interleukin-6 and from EK . Positive_regulation FCER2 TNF 7547698 327053 *regulates* IL-4 induced [Fc epsilon RII/CD23] gene expression and soluble Fc epsilon RII release by human monocytes . Positive_regulation FCER2 TNF 7643018 318088 [Fc epsilon RII] was also *triggered* by IFN-gamma , , and IL-6 on all the cell lines , an effect blocked by calcitriol . Positive_regulation FCER2 TNF 7949182 277329 [CD23] ligation also *induced* the production of by U937 cells . Positive_regulation FCER2 TNF 8182161 256556 In the present study , we showed that the ligation of [CD23] by IgE/anti-IgE immune complexes or specific monoclonal antibody *induces* a dose dependent release of interleukin 6 and from EK . Positive_regulation FCER2 TNF 9122614 423984 *regulates* GM-CSF- , IL-3- or M-CSF induced [Fc epsilon RII/CD23] gene expression and soluble Fc epsilon RII release by human monocytes . Positive_regulation FCGR1A ITGAL 10979209 729814 Cross linking of neither nor CD11c *induced* [CD64] expression . Positive_regulation FCGR1A ITGB2 10979209 729812 We found that the cross linking of CD11b as well as of *induced* comparable rapid increases in [CD64] expression on the surface of PMNs , occurring within 15 minutes of exposure . Positive_regulation FCGR1A TNF 2137489 127121 Cross linking of both [Fc gamma RI] and Fc gamma RII *induces* secretion of by human monocytes , requiring high affinity Fc-Fc gamma R interactions . Positive_regulation FCGR1A TNF 23299081 2737874 Both IFN-a and IFN-ß strongly reduced the production of IL-12p40 , IL-1ß and and the IFN-? *induced* CD54 and [CD64] expression . Positive_regulation FCGR1A TNF 8296157 248377 , as well as interferon-gamma (IFN-gamma) or interleukin-6 (IL-6) *had* a significant up-regulating effect on U937 expression of [Fc gamma RI/CD64] . Positive_regulation FCGR1A TNF 8296157 248383 In contrast to U937 cells , did not *enhance* significantly [Fc gamma RI] expression on human monocytes . Positive_regulation FCGR3A JAG1 11390467 822530 In this study , we show that , upon *stimulation* by nonpeptidic , Vgamma9Vdelta2 T cells express [FcgammaRIIIA] ( CD16 ) , a receptor that is constitutively expressed on NK cells . Positive_regulation FDFT1 TNF 11111077 757489 [SQS] activity , protein , and mRNA levels are *regulated* by cholesterol status and by the cytokines and IL-1beta . Positive_regulation FDPS CD14 11779220 900064 Herein we provide evidence that [FPS] activation of NF-kappaB can be *augmented* by the cell surface expression of . Positive_regulation FER EPHB2 21518868 2428897 EGF activates NF-?B and stimulates phosphorylation of [FER] , EGF receptor (EGFR) , and ERK p42/p44 , and decreased expression of FER or inhibition of phosphorylation *inhibits* the EGF induced activation of NF-?B . Positive_regulation FERMT3 ITGB2 23595985 2789666 It has a major role in membrane association of [kindlin 3] that is *enhanced* by the binding of to intercellular adhesion molecule 1 ( ICAM-1 ) . Positive_regulation FFAR4 FAS 20813258 2314794 *Stimulation* of [GPR120] with omega-3 or a chemical agonist causes broad anti-inflammatory effects in monocytic RAW 264.7 cells and in primary intraperitoneal macrophages . Positive_regulation FGA ANGPT1 19052021 2047386 [Fibrinogen] *induced* the production of interleukin 6 (IL6) , interleukin 8 (IL8) , monocyte chemoattractant protein-1 , vascular endothelial growth factor , and type I collagen , but not proliferation or intercellular adhesion molecule-1 expression . Positive_regulation FGB F2R 15692097 1382582 Between 0 % and 15 % oxidation , the p38 ( MAPK ) route enhances [fibrinogen] binding *induced* by ( PAR-1 ) -activating peptide ( TRAP ) , and signaling via Ca2+ is absent . Positive_regulation FGB F2R 19422454 2101108 We found that FXIII-A represents the only detectable source of TG activity in platelets and that the binding of [fibrinogen] in *response* to stimulation was significantly reduced in platelets from the patients . Positive_regulation FGB FHL1 19850343 2165357 Factor H and inactivate complement and plasminogen can be *activated* to plasmin which then degrades the extra-cellular matrix component [fibrinogen] . Positive_regulation FGB HES2 20028511 2176786 At 40 % but not at 10 % haemodilution rate , 200/0.5 also *increased* platelet [fibrinogen] binding and both HES solutions increased expression of CD62P , the main receptor for platelet-leukocyte adhesion . Positive_regulation FGB IL1B 8525785 331124 In conclusion , subcutaneous ( probably by stimulation of interleukin-6 ) strongly *induces* [fibrinogen] and orosomucoid expression in rat liver , and suppresses immunohistochemically stainable albumin in a heterogenous way , mainly in the periportal zone . Positive_regulation FGB ITGB2 3053736 99571 Evidence is presented here that the leukocyte adhesion receptor can be specifically *induced* to bind [fibrinogen] with characteristics immunochemically and functionally distinct from the established Arg-Gly-Asp directed fibrinogen receptors . Positive_regulation FGB MMP28 10930399 737192 *induced* degradation of [fibrinogen] supports a plasmin independent fibrinolysis mechanism . Positive_regulation FGB MMP7 10930399 737207 *induced* degradation of [fibrinogen] supports a plasmin independent fibrinolysis mechanism . Positive_regulation FGB PLAT 11775254 766384 The plasma level of platelet alpha-granular membrane protein-140 , soluble fibrinomonomer complex , thrombomodulin , and D-dimer significantly *increased* , [fibrinogen] , antigen level of protein C , plasminogen , alpha 2-plasminogen inhibitor and plasminogen activator inhibitor decreased at diagnosis , were restored to normal after complete remission but protein C activity and protein S remained elevated in ATRA group . Positive_regulation FGB PLAT 17890121 1811197 Moreover , incubation of S. agalactiae with either plasminogen alone , or plasminogen plus [fibrinogen] , in the *presence* of enhanced its virulence in C57BL/6 mice , suggesting that acquisition of plasmin-like activity by the bacteria increase their invasiveness . Positive_regulation FGB PLAT 1900308 153966 Soluble fibrin degradation products potentiate *induced* [fibrinogen] proteolysis . Positive_regulation FGB TGM2 1983462 149851 In this report , we highlight some of the major distinguishing characteristics of this novel type of *mediated* [fibrinogen] - cell interaction . Positive_regulation FGB TGM2 2573600 122178 *mediated* cross linking of [fibrinogen] by human umbilical vein endothelial cells . Positive_regulation FGB TGM2 6111391 14678 The enzyme is *involved* in the binding of the [fibrinogen] or fibrin to the cell surface . Positive_regulation FGB TNF 2201637 140475 Tumor necrosis factor (TNF) is induced in mice by Candida albicans : *role* of in [fibrinogen] increase . Positive_regulation FGB TNF 2460412 98542 Interleukin 1 ( both alpha and beta ) , and lymphotoxin also *increased* plasma [fibrinogen] , a marker of liver acute phase inflammatory response . Positive_regulation FGB TNF 8867673 344810 In the absence of divalent cations or in the presence of Ca2+ alone , PMN did not adhere to [fibrinogen] in *response* to . Positive_regulation FGF1 ANGPT1 10068209 594089 markedly *increases* the survival of vascular networks ( up to 96 hours ) exposed to either vascular endothelial growth factor or endothelial cell growth supplement , a form of [acidic fibroblast growth factor] . Positive_regulation FGF1 EPHB2 10671553 666913 kinase inhibition *diminished* VEGF- , [FGF-] , and EGF promoted thymidine incorporation into DNA . Positive_regulation FGF1 EPHB2 11449001 835909 [FGF] *induced* sustained activation of extracellular signal regulated kinase ( ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation FGF1 EPHB2 17852407 1817857 [FGF] *induced* a transient activation of , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation FGF1 EPHB2 18216067 1903413 Phosphorylation of Akt , and MEK were *induced* by [FGF-1] in W/W cells but not in W/M cells . Positive_regulation FGF1 FGFBP1 11509569 868517 Furthermore , *enhances* [FGF-1-] and FGF-2 dependent proliferation of NIH-3T3 fibroblasts and FGF-2 induced extracellular signal regulated kinase 2 phosphorylation . Positive_regulation FGF1 FGFBP1 15806171 1439230 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Positive_regulation FGF1 FGFBP1 15806171 1439362 The ( FGF-BP ) binds and *activates* [FGF-1] and FGF-2 , thereby contributing to tumor angiogenesis . Positive_regulation FGF1 FGFBP1 17766586 1822786 Functionally , shuttles FGFs from binding sites in ECMs to cell surfaces and *enhances* [FGF] binding and signaling , whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation . Positive_regulation FGF1 HBEGF 8756003 374675 In the present study , we report that treatment of serum starved at aortic SMCs can *induce* fibroblast growth factor (FGF)-2 ( basic FGF ) gene expression but not [FGF-1] ( acidic FGF ) gene expression . Positive_regulation FGF1 IL1B 11732857 885242 *induced* expression of matrix metalloproteinases and gliostatin/platelet derived [endothelial cell growth factor] ( GLS/PD-ECGF ) in a chondrosarcoma cell line ( OUMS-27 ) . Positive_regulation FGF1 IL1B 7662960 321744 To address the direct effects of FGF , we investigated whether [FGF] *induced* production of , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation FGF1 JAG1 19481073 2102439 [FGF] *induced* expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation FGF1 MAP2K6 11802165 905943 Here we show that in zebrafish , Sef functions as a feedback induced antagonist of *mediated* [FGF] signalling . Positive_regulation FGF1 MAP2K6 12468533 1055304 Overexpression of Ets-2 resulted in the induction of Xbra , and expression of the dominant negative Ets-2 inhibited [FGF-] or constitutively active *induced* Xbra expression . Positive_regulation FGF1 MAP2K6 15231676 1269254 Despite a short lived activation of Ras and Raf-1 by all three of the growth factors , both [FGF-1] and HRGbeta1 , unlike EGF , *induced* a prolonged activation of and ERK1/2 in these cells . Positive_regulation FGF1 MAP2K6 18216067 1903419 Phosphorylation of Akt , ERK and were *induced* by [FGF-1] in W/W cells but not in W/M cells . Positive_regulation FGF1 MSX1 20702560 2312635 Overexpression of was *sufficient* to repress [FGF] gene expression and cell proliferation , thereby promoting cardiomyocyte differentiation . Positive_regulation FGF1 NGFR 2155007 129321 Thus , the development of sympathetic neurons may involve a relay , in which [FGF] both initiates differentiation and *induces* the , which in turn controls further maturation and survival . Positive_regulation FGF1 TMEM100 14688794 1190851 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF1 TMEM156 14688794 1190869 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF1 TMEM211 14688794 1190949 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF1 TMEM213 14688794 1190886 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF1 TNF 8780398 380085 This proliferative effect is mediated through the *up-regulation* of [fibroblast growth factor-1] by . Positive_regulation FGF1 TNF 8780398 380086 The addition of specific fibroblast growth factor-1 antisense oligonucleotides inhibits *induced* [fibroblast growth factor-1] expression , thus inhibiting the growth and triggering apoptosis of spontaneously transformed human umbilical vein endothelial cells . Positive_regulation FGF10 EPHB2 10671553 666927 kinase inhibition *diminished* VEGF- , [FGF-] , and EGF promoted thymidine incorporation into DNA . Positive_regulation FGF10 EPHB2 11449001 835910 [FGF] *induced* sustained activation of extracellular signal regulated kinase ( ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation FGF10 EPHB2 17852407 1817861 [FGF] *induced* a transient activation of , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation FGF10 FGFBP1 15806171 1439233 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Positive_regulation FGF10 FGFBP1 17766586 1822787 Functionally , shuttles FGFs from binding sites in ECMs to cell surfaces and *enhances* [FGF] binding and signaling , whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation . Positive_regulation FGF10 IL1B 7662960 321747 To address the direct effects of FGF , we investigated whether [FGF] *induced* production of , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation FGF10 JAG1 19481073 2102441 [FGF] *induced* expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation FGF10 MAP2K6 11802165 905964 Here we show that in zebrafish , Sef functions as a feedback induced antagonist of *mediated* [FGF] signalling . Positive_regulation FGF10 MAP2K6 12468533 1055312 Overexpression of Ets-2 resulted in the induction of Xbra , and expression of the dominant negative Ets-2 inhibited [FGF-] or constitutively active *induced* Xbra expression . Positive_regulation FGF10 MSX1 20702560 2312636 Overexpression of was sufficient to *repress* [FGF] gene expression and cell proliferation , thereby promoting cardiomyocyte differentiation . Positive_regulation FGF10 NGFR 2155007 129322 Thus , the development of sympathetic neurons may involve a relay , in which [FGF] both initiates differentiation and *induces* the , which in turn controls further maturation and survival . Positive_regulation FGF10 RARB 16427040 1534041 We show that activation of , but not alpha , *induces* expression of the fibroblast growth factor [Fgf10] and bud morphogenesis in the lung field . Positive_regulation FGF10 TMEM100 14688794 1191020 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF10 TMEM156 14688794 1191038 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF10 TMEM211 14688794 1191118 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF10 TMEM213 14688794 1191055 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF11 EPHB2 10671553 666941 kinase inhibition *diminished* VEGF- , [FGF-] , and EGF promoted thymidine incorporation into DNA . Positive_regulation FGF11 EPHB2 11449001 835911 [FGF] *induced* sustained activation of extracellular signal regulated kinase ( ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation FGF11 EPHB2 17852407 1817865 [FGF] *induced* a transient activation of , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation FGF11 FGFBP1 15806171 1439236 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Positive_regulation FGF11 FGFBP1 17766586 1822788 Functionally , shuttles FGFs from binding sites in ECMs to cell surfaces and *enhances* [FGF] binding and signaling , whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation . Positive_regulation FGF11 IL1B 7662960 321750 To address the direct effects of FGF , we investigated whether [FGF] *induced* production of , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation FGF11 JAG1 19481073 2102443 [FGF] *induced* expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation FGF11 MAP2K6 11802165 905985 Here we show that in zebrafish , Sef functions as a feedback induced antagonist of *mediated* [FGF] signalling . Positive_regulation FGF11 MAP2K6 12468533 1055320 Overexpression of Ets-2 resulted in the induction of Xbra , and expression of the dominant negative Ets-2 inhibited [FGF-] or constitutively active *induced* Xbra expression . Positive_regulation FGF11 MSX1 20702560 2312637 Overexpression of was sufficient to *repress* [FGF] gene expression and cell proliferation , thereby promoting cardiomyocyte differentiation . Positive_regulation FGF11 NGFR 2155007 129323 Thus , the development of sympathetic neurons may involve a relay , in which [FGF] both initiates differentiation and *induces* the , which in turn controls further maturation and survival . Positive_regulation FGF11 TMEM100 14688794 1191189 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF11 TMEM156 14688794 1191207 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF11 TMEM211 14688794 1191287 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF11 TMEM213 14688794 1191224 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF12 EPHB2 10671553 666955 kinase inhibition *diminished* VEGF- , [FGF-] , and EGF promoted thymidine incorporation into DNA . Positive_regulation FGF12 EPHB2 11449001 835912 [FGF] *induced* sustained activation of extracellular signal regulated kinase ( ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation FGF12 EPHB2 17852407 1817869 [FGF] *induced* a transient activation of , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation FGF12 FGFBP1 15806171 1439239 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Positive_regulation FGF12 FGFBP1 17766586 1822789 Functionally , shuttles FGFs from binding sites in ECMs to cell surfaces and *enhances* [FGF] binding and signaling , whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation . Positive_regulation FGF12 IL1B 7662960 321753 To address the direct effects of FGF , we investigated whether [FGF] *induced* production of , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation FGF12 JAG1 19481073 2102445 [FGF] *induced* expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation FGF12 MAP2K6 11802165 906006 Here we show that in zebrafish , Sef functions as a feedback induced antagonist of *mediated* [FGF] signalling . Positive_regulation FGF12 MAP2K6 12468533 1055328 Overexpression of Ets-2 resulted in the induction of Xbra , and expression of the dominant negative Ets-2 inhibited [FGF-] or constitutively active *induced* Xbra expression . Positive_regulation FGF12 MSX1 20702560 2312638 Overexpression of was *sufficient* to repress [FGF] gene expression and cell proliferation , thereby promoting cardiomyocyte differentiation . Positive_regulation FGF12 NGFR 2155007 129324 Thus , the development of sympathetic neurons may involve a relay , in which [FGF] both initiates differentiation and *induces* the , which in turn controls further maturation and survival . Positive_regulation FGF12 TMEM100 14688794 1191358 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF12 TMEM156 14688794 1191376 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF12 TMEM211 14688794 1191456 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF12 TMEM213 14688794 1191393 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF13 EPHB2 10671553 666969 kinase inhibition *diminished* VEGF- , [FGF-] , and EGF promoted thymidine incorporation into DNA . Positive_regulation FGF13 EPHB2 11449001 835913 [FGF] *induced* sustained activation of extracellular signal regulated kinase ( ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation FGF13 EPHB2 17852407 1817873 [FGF] *induced* a transient activation of , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation FGF13 FGFBP1 15806171 1439242 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Positive_regulation FGF13 FGFBP1 17766586 1822790 Functionally , shuttles FGFs from binding sites in ECMs to cell surfaces and *enhances* [FGF] binding and signaling , whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation . Positive_regulation FGF13 IL1B 7662960 321756 To address the direct effects of FGF , we investigated whether [FGF] *induced* production of , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation FGF13 JAG1 19481073 2102447 [FGF] *induced* expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation FGF13 MAP2K6 11802165 906027 Here we show that in zebrafish , Sef functions as a feedback induced antagonist of *mediated* [FGF] signalling . Positive_regulation FGF13 MAP2K6 12468533 1055336 Overexpression of Ets-2 resulted in the induction of Xbra , and expression of the dominant negative Ets-2 inhibited [FGF-] or constitutively active *induced* Xbra expression . Positive_regulation FGF13 MSX1 20702560 2312639 Overexpression of was sufficient to *repress* [FGF] gene expression and cell proliferation , thereby promoting cardiomyocyte differentiation . Positive_regulation FGF13 NGFR 2155007 129325 Thus , the development of sympathetic neurons may involve a relay , in which [FGF] both initiates differentiation and *induces* the , which in turn controls further maturation and survival . Positive_regulation FGF13 TMEM100 14688794 1191527 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF13 TMEM156 14688794 1191545 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF13 TMEM211 14688794 1191625 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF13 TMEM213 14688794 1191562 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF14 EPHB2 10671553 666983 kinase inhibition *diminished* VEGF- , [FGF-] , and EGF promoted thymidine incorporation into DNA . Positive_regulation FGF14 EPHB2 11449001 835914 [FGF] *induced* sustained activation of extracellular signal regulated kinase ( ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation FGF14 EPHB2 17852407 1817877 [FGF] *induced* a transient activation of , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation FGF14 FGFBP1 15806171 1439245 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Positive_regulation FGF14 FGFBP1 17766586 1822791 Functionally , shuttles FGFs from binding sites in ECMs to cell surfaces and *enhances* [FGF] binding and signaling , whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation . Positive_regulation FGF14 IL1B 7662960 321759 To address the direct effects of FGF , we investigated whether [FGF] *induced* production of , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation FGF14 JAG1 19481073 2102449 [FGF] *induced* expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation FGF14 MAP2K6 11802165 906048 Here we show that in zebrafish , Sef functions as a feedback induced antagonist of *mediated* [FGF] signalling . Positive_regulation FGF14 MAP2K6 12468533 1055344 Overexpression of Ets-2 resulted in the induction of Xbra , and expression of the dominant negative Ets-2 inhibited [FGF-] or constitutively active *induced* Xbra expression . Positive_regulation FGF14 MSX1 20702560 2312640 Overexpression of was *sufficient* to repress [FGF] gene expression and cell proliferation , thereby promoting cardiomyocyte differentiation . Positive_regulation FGF14 NGFR 2155007 129326 Thus , the development of sympathetic neurons may involve a relay , in which [FGF] both initiates differentiation and *induces* the , which in turn controls further maturation and survival . Positive_regulation FGF14 TMEM100 14688794 1191696 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF14 TMEM156 14688794 1191714 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF14 TMEM211 14688794 1191794 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF14 TMEM213 14688794 1191731 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF16 EPHB2 10671553 666997 kinase inhibition *diminished* VEGF- , [FGF-] , and EGF promoted thymidine incorporation into DNA . Positive_regulation FGF16 EPHB2 11449001 835915 [FGF] *induced* sustained activation of extracellular signal regulated kinase ( ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation FGF16 EPHB2 17852407 1817881 [FGF] *induced* a transient activation of , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation FGF16 FGFBP1 15806171 1439248 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Positive_regulation FGF16 FGFBP1 17766586 1822792 Functionally , shuttles FGFs from binding sites in ECMs to cell surfaces and *enhances* [FGF] binding and signaling , whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation . Positive_regulation FGF16 IL1B 7662960 321762 To address the direct effects of FGF , we investigated whether [FGF] *induced* production of , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation FGF16 JAG1 19481073 2102451 [FGF] *induced* expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation FGF16 MAP2K6 11802165 906069 Here we show that in zebrafish , Sef functions as a feedback induced antagonist of *mediated* [FGF] signalling . Positive_regulation FGF16 MAP2K6 12468533 1055352 Overexpression of Ets-2 resulted in the induction of Xbra , and expression of the dominant negative Ets-2 inhibited [FGF-] or constitutively active *induced* Xbra expression . Positive_regulation FGF16 MSX1 20702560 2312641 Overexpression of was sufficient to *repress* [FGF] gene expression and cell proliferation , thereby promoting cardiomyocyte differentiation . Positive_regulation FGF16 NGFR 2155007 129327 Thus , the development of sympathetic neurons may involve a relay , in which [FGF] both initiates differentiation and *induces* the , which in turn controls further maturation and survival . Positive_regulation FGF16 TMEM100 14688794 1191865 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF16 TMEM156 14688794 1191883 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF16 TMEM211 14688794 1191963 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF16 TMEM213 14688794 1191900 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF17 EPHB2 10671553 667011 kinase inhibition *diminished* VEGF- , [FGF-] , and EGF promoted thymidine incorporation into DNA . Positive_regulation FGF17 EPHB2 11449001 835916 [FGF] *induced* sustained activation of extracellular signal regulated kinase ( ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation FGF17 EPHB2 17852407 1817885 [FGF] *induced* a transient activation of , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation FGF17 FGFBP1 15806171 1439251 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Positive_regulation FGF17 FGFBP1 17766586 1822793 Functionally , shuttles FGFs from binding sites in ECMs to cell surfaces and *enhances* [FGF] binding and signaling , whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation . Positive_regulation FGF17 IL1B 7662960 321765 To address the direct effects of FGF , we investigated whether [FGF] *induced* production of , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation FGF17 JAG1 19481073 2102453 [FGF] *induced* expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation FGF17 MAP2K6 11802165 906090 Here we show that in zebrafish , Sef functions as a feedback induced antagonist of *mediated* [FGF] signalling . Positive_regulation FGF17 MAP2K6 12468533 1055360 Overexpression of Ets-2 resulted in the induction of Xbra , and expression of the dominant negative Ets-2 inhibited [FGF-] or constitutively active *induced* Xbra expression . Positive_regulation FGF17 MSX1 20702560 2312642 Overexpression of was *sufficient* to repress [FGF] gene expression and cell proliferation , thereby promoting cardiomyocyte differentiation . Positive_regulation FGF17 NGFR 2155007 129328 Thus , the development of sympathetic neurons may involve a relay , in which [FGF] both initiates differentiation and *induces* the , which in turn controls further maturation and survival . Positive_regulation FGF17 TMEM100 14688794 1192034 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF17 TMEM156 14688794 1192052 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF17 TMEM211 14688794 1192132 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF17 TMEM213 14688794 1192069 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF18 EPHB2 10671553 667025 kinase inhibition *diminished* VEGF- , [FGF-] , and EGF promoted thymidine incorporation into DNA . Positive_regulation FGF18 EPHB2 11449001 835917 [FGF] *induced* sustained activation of extracellular signal regulated kinase ( ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation FGF18 EPHB2 17852407 1817889 [FGF] *induced* a transient activation of , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation FGF18 FGFBP1 15806171 1439254 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Positive_regulation FGF18 FGFBP1 17766586 1822794 Functionally , shuttles FGFs from binding sites in ECMs to cell surfaces and *enhances* [FGF] binding and signaling , whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation . Positive_regulation FGF18 IL1B 18565769 1984269 In the *presence* of , [FGF-18] increased expression of ADAMTS-4 , aggrecan , BMP-2 , COL2A1 , CCL3 , CCL4 , CCL20 , CXCL1 , CXCL3 , CXCL6 , IL-1beta , IL-6 , and IL-8 and decreased ADAMTS-5 , MMP-13 , CCL2 , and CCL8 . Positive_regulation FGF18 IL1B 7662960 321768 To address the direct effects of FGF , we investigated whether [FGF] *induced* production of , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation FGF18 JAG1 19481073 2102455 [FGF] *induced* expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation FGF18 MAP2K6 11802165 906111 Here we show that in zebrafish , Sef functions as a feedback induced antagonist of *mediated* [FGF] signalling . Positive_regulation FGF18 MAP2K6 12468533 1055368 Overexpression of Ets-2 resulted in the induction of Xbra , and expression of the dominant negative Ets-2 inhibited [FGF-] or constitutively active *induced* Xbra expression . Positive_regulation FGF18 MSX1 20702560 2312643 Overexpression of was sufficient to *repress* [FGF] gene expression and cell proliferation , thereby promoting cardiomyocyte differentiation . Positive_regulation FGF18 NGFR 2155007 129329 Thus , the development of sympathetic neurons may involve a relay , in which [FGF] both initiates differentiation and *induces* the , which in turn controls further maturation and survival . Positive_regulation FGF18 TMEM100 14688794 1192203 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF18 TMEM156 14688794 1192221 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF18 TMEM211 14688794 1192301 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF18 TMEM213 14688794 1192238 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF19 EPHB2 10671553 667039 kinase inhibition *diminished* VEGF- , [FGF-] , and EGF promoted thymidine incorporation into DNA . Positive_regulation FGF19 EPHB2 11449001 835918 [FGF] *induced* sustained activation of extracellular signal regulated kinase ( ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation FGF19 EPHB2 17852407 1817893 [FGF] *induced* a transient activation of , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation FGF19 FGFBP1 15806171 1439257 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Positive_regulation FGF19 FGFBP1 17766586 1822795 Functionally , shuttles FGFs from binding sites in ECMs to cell surfaces and *enhances* [FGF] binding and signaling , whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation . Positive_regulation FGF19 IL1B 7662960 321771 To address the direct effects of FGF , we investigated whether [FGF] *induced* production of , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation FGF19 JAG1 19481073 2102457 [FGF] *induced* expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation FGF19 MAP2K6 11802165 906132 Here we show that in zebrafish , Sef functions as a feedback induced antagonist of *mediated* [FGF] signalling . Positive_regulation FGF19 MAP2K6 12468533 1055376 Overexpression of Ets-2 resulted in the induction of Xbra , and expression of the dominant negative Ets-2 inhibited [FGF-] or constitutively active *induced* Xbra expression . Positive_regulation FGF19 MSX1 20702560 2312644 Overexpression of was *sufficient* to repress [FGF] gene expression and cell proliferation , thereby promoting cardiomyocyte differentiation . Positive_regulation FGF19 NGFR 2155007 129330 Thus , the development of sympathetic neurons may involve a relay , in which [FGF] both initiates differentiation and *induces* the , which in turn controls further maturation and survival . Positive_regulation FGF19 TMEM100 14688794 1192372 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF19 TMEM100 17711860 1800877 We show that betaKlotho , a single-pass highly expressed in liver and fat , induced ERK1/2 phosphorylation in response to FGF19 treatment and significantly *increased* the interactions between [FGF19] and FGFR4 . Positive_regulation FGF19 TMEM156 14688794 1192390 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF19 TMEM156 17711860 1800895 We show that betaKlotho , a single-pass highly expressed in liver and fat , induced ERK1/2 phosphorylation in response to FGF19 treatment and significantly *increased* the interactions between [FGF19] and FGFR4 . Positive_regulation FGF19 TMEM211 14688794 1192470 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF19 TMEM211 17711860 1800975 We show that betaKlotho , a single-pass highly expressed in liver and fat , induced ERK1/2 phosphorylation in response to FGF19 treatment and significantly *increased* the interactions between [FGF19] and FGFR4 . Positive_regulation FGF19 TMEM213 14688794 1192407 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF19 TMEM213 17711860 1800912 We show that betaKlotho , a single-pass highly expressed in liver and fat , induced ERK1/2 phosphorylation in response to FGF19 treatment and significantly *increased* the interactions between [FGF19] and FGFR4 . Positive_regulation FGF2 CCND1 7876159 298413 Expression of was *induced* in myoblasts by [bFGF] and TGF beta ( albeit with different kinetics for each factor ) , while induction of cyclin D3 expression was inhibited by these growth factors . Positive_regulation FGF2 CCND1 9135019 427549 [bFGF] *induced* an increase in , cyclin E , and cyclin dependent kinase 4 (cdk4) protein levels in a bFGF dose dependent manner . Positive_regulation FGF2 CTGF 11148815 761013 FCS , TGF-beta 1 , TGF-beta 3 , [bFGF] , and EGF *induced* an upregulation of gene expression in RVEC in a time dependent manner . Positive_regulation FGF2 EDN2 11956566 767223 [Basic fibroblast growth factor] *increases* nitric oxide and production in rat aorta . Positive_regulation FGF2 EDN2 23469133 2750250 Our findings indicate that the increased expression of PR Edn2 increases PR survival , and suggest that the *dependent* increase in PR expression of [FGF2] may contribute to the augmented survival . Positive_regulation FGF2 EPHB2 10671553 667053 kinase inhibition *diminished* VEGF- , [FGF-] , and EGF promoted thymidine incorporation into DNA . Positive_regulation FGF2 EPHB2 10854258 704249 Indeed , long-term activation and high bcl-x ( L ) levels are *necessary* for the survival activity of both exogenous and endogenous [FGF2] . Positive_regulation FGF2 EPHB2 11449001 835919 [FGF] *induced* sustained activation of extracellular signal regulated kinase ( ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation FGF2 EPHB2 11850809 913014 [bFGF-induces] phosphorylation of FGFr 1 and *activation* of in ESFT cells that die when exposed to bFGF . Positive_regulation FGF2 EPHB2 15247255 1295842 [Fibroblast growth factor-2] induction of platelet derived growth factor-C chain transcription in vascular smooth muscle cells is *dependent* but not JNK dependent and mediated by Egr-1 . Positive_regulation FGF2 EPHB2 15247255 1295854 Moreover , using pharmacological inhibitors we demonstrate the critical *role* of but not JNK in [FGF-2-inducible] PDGF-C expression . Positive_regulation FGF2 EPHB2 15564063 1341395 Inhibitors of signaling blocked up-regulation of the MMP-13 promoter by RUNX2 and FGF2 , and also *blocked* the activation of RUNX2 by [FGF2] . Positive_regulation FGF2 EPHB2 17385725 1727722 We examined early signaling events in the CB/CMZ and found that [FGF2] or Shh *induced* a robust phosphorylation during the early stages of retina regeneration . Positive_regulation FGF2 EPHB2 17852407 1817897 [FGF] *induced* a transient activation of , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation FGF2 EPHB2 18656513 1972801 Relative *role* of upstream regulators of Akt , and CREB in NCAM- and [FGF2] mediated signalling . Positive_regulation FGF2 EPHB2 20460816 2275701 [FGF2] *induces* phosphorylation through Grb2 and PKC during quiescent myogenic cell activation . Positive_regulation FGF2 EPHB2 21663947 2459694 Using luciferase reporter assays and western blot analysis , we detected the effect of hSef on *mediated* [FGF2] signaling . Positive_regulation FGF2 EPHB2 22277757 2575620 The PKCd independent *activation* of by [FGF2] was confirmed by Western blotting , as was the Cx43 dependent enhancement of ERK activation . Positive_regulation FGF2 EPHB2 24125755 2889232 [FGF2] induced TAZ expression was *stimulated* by ( extracellular signal regulated kinase ) activation and the inhibition of ERK blocked TAZ expression . Positive_regulation FGF2 F2R 10625622 658566 *activating* peptide ( TRAP ) and [basic fibroblast growth factor (bFGF)] stimulated SMC proliferation and rapidly enhanced the NF-kappaB transcriptional activity in a dose dependent manner . Positive_regulation FGF2 F2R 7955141 277790 mRNA synthesis was *induced* by both [basic fibroblast growth factor] ( maximal stimulation of 1.8-fold at 1 hour ) and platelet derived growth factor ( maximal stimulation of 2.4-fold at 8 and 24 hours ) in quiesced cultured rat aortic smooth muscle cells . Positive_regulation FGF2 FGFBP1 15806171 1439260 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Positive_regulation FGF2 FGFBP1 15806171 1439365 The ( FGF-BP ) binds and *activates* FGF-1 and [FGF-2] , thereby contributing to tumor angiogenesis . Positive_regulation FGF2 FGFBP1 17766586 1822796 Functionally , shuttles FGFs from binding sites in ECMs to cell surfaces and *enhances* [FGF] binding and signaling , whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation . Positive_regulation FGF2 FGFBP1 9178765 434249 Recently , we have shown that a novel human *mediates* the release of immobilized [FGF-2] from the EM . Positive_regulation FGF2 FGFBP1 9334727 457916 We found that the reduction of *reduced* the release of biologically active [basic FGF (bFGF)] from cells in culture . Positive_regulation FGF2 HAS3 19577615 2129253 [bFGF] *induces* changes in and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells . Positive_regulation FGF2 HBEGF 10579352 569835 Expression of both ARG and mRNAs was *induced* in cultured prostate SMC by [fibroblast growth factor-2] , a human prostate SMC mitogen linked to prostate disease . Positive_regulation FGF2 HBEGF 12882762 1150060 *regulates* elastin and [FGF-2] expression in pulmonary fibroblasts . Positive_regulation FGF2 HBEGF 8756003 374676 In the present study , we report that treatment of serum starved at aortic SMCs can *induce* [fibroblast growth factor (FGF)-2] ( basic FGF ) gene expression but not FGF-1 ( acidic FGF ) gene expression . Positive_regulation FGF2 HBEGF 8756003 374678 *induction* of [FGF-2] mRNA levels can be inhibited by treating cells with the anti-inflammatory glucocorticoid dexamethasone or the glycosaminoglycan heparin . Positive_regulation FGF2 HBEGF 9796995 543506 When added to the medium , transforming growth factor-alpha , [basic fibroblast growth factor] , or HB-EGF rapidly *induced* mRNA expression . Positive_regulation FGF2 IL1B 11771938 899292 RT-PCR analysis demonstrated that CNTF increased levels of [FGF-2] and nerve growth factor (NGF) mRNA and that *increased* NGF and hepatocyte growth factor mRNA levels . Positive_regulation FGF2 IL1B 11771938 899299 Furthermore , both CNTF and *stimulated* the release of [FGF-2] from cultured spinal cord astrocytes . Positive_regulation FGF2 IL1B 15173165 1273471 [FGF-2] *induced* by through the action of phosphatidylinositol 3-kinase mediates endothelial mesenchymal transformation in corneal endothelial cells . Positive_regulation FGF2 IL1B 16445521 1521665 The production of VEGF , [bFGF] and TGF-beta respectively was *enhanced* by both and TNF-alpha . Positive_regulation FGF2 IL1B 17717918 1789481 The mRNA expression level decreased and that of [bFGF] *increased* in both groups after treatment significantly ( P < 0.01 ) , but showed insignificant difference between the two groups . Positive_regulation FGF2 IL1B 19136710 2060845 Common and distinct pathways for cellular activities in [FGF-2] signaling *induced* by in corneal endothelial cells . Positive_regulation FGF2 IL1B 19136710 2060846 To determine the mechanism by which IL-1beta induces FGF-2 and to elucidate the signaling pathways of *induced* [FGF-2] in corneal endothelial cells ( CECs ) . Positive_regulation FGF2 IL1B 19136710 2060850 The *induced* [FGF-2] exerted cellular activities using distinct pathways : the second wave of activation of PI 3-kinase and p38 was involved in cell migration , whereas cell proliferation was simultaneously stimulated by ERK1/2 and the second wave of PI 3-kinase . Positive_regulation FGF2 IL1B 19136710 2060851 The *induced* [FGF-2] facilitates cell migration via PI 3-kinase and p38 , whereas it stimulates cell proliferation using PI 3-kinase and ERK1/2 in parallel pathways . Positive_regulation FGF2 IL1B 19797202 2186902 *Induction* of [FGF-2] synthesis by in aqueous humor through P13-kinase and p38 in rabbit corneal endothelium . Positive_regulation FGF2 IL1B 7485400 332011 By means of reverse transcription polymerase chain reaction controlled by Southern blots , [bFGF-mRNA] expression of HMC was *enhanced* by IL-1 alpha , , and LPS . Positive_regulation FGF2 IL1B 7533232 286228 *increases* [basic fibroblast growth factor] mRNA expression in adult rat brain and organotypic hippocampal cultures . Positive_regulation FGF2 IL1B 7533232 286231 To determine if IL-1 beta effects were independent of activation of the hypothalamo-pituitary-adrenal axis , and to compare the cellular localization of increases in [bFGF] mRNA expression *induced* by and bFGF , the regulation of bFGF expression was also studied in organotypic hippocampal slice cultures . Positive_regulation FGF2 IL1B 7533232 286232 These findings suggest that *induction* of [bFGF] contributes to the coactivation of these substances following various forms of insult to the CNS and initiates a cascade of trophic interactions that regulates processes of glial proliferation , neurotrophic factor expression , and neuroprotection . Positive_regulation FGF2 IL1B 7662960 321774 To address the direct effects of FGF , we investigated whether [FGF] *induced* production of , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation FGF2 IL1B 8881517 390779 This study was designed to examine , first , whether the effects of are also partially *mediated* by [fibroblast growth factor-2 (FGF-2)] , which is another important growth factor in atherosclerotic lesions , and , secondly , whether chronic treatment with FGF-2 per se also induces histological and functional changes in porcine coronary arteries in vivo . Positive_regulation FGF2 IL1B 8881517 390780 These results suggest that the vascular effects of may also be *mediated* by [FGF-2] in our swine model and that chronic treatment with FGF-2 also causes coronary arteriosclerotic changes and vasospastic responses in vivo . Positive_regulation FGF2 IL1B 9029130 413587 Production and release of [bFGF] is *induced* in a synergistic fashion by TNF-alpha , , and IFN-gamma , and its release is further promoted by low cell density and by the serine proteases plasmin and thrombin . Positive_regulation FGF2 IL1B 9124460 419558 , which like ANG II and ET-1 is known to activate mitogen activated protein kinases in both ARVM and CMEC , *increased* [bFGF] mRNA levels only in cardiac myocytes . Positive_regulation FGF2 JAG1 19481073 2102459 [FGF] *induced* expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation FGF2 MAP2K6 11564685 863270 The specific inhibitor , PD98059 , *blocked* the activation of the Erks by ACTH and [basic fibroblast growth factor] , indicating that Mek is the upstream activator of Erk . Positive_regulation FGF2 MAP2K6 11802165 906153 Here we show that in zebrafish , Sef functions as a feedback induced antagonist of *mediated* [FGF] signalling . Positive_regulation FGF2 MAP2K6 12468533 1055384 Overexpression of Ets-2 resulted in the induction of Xbra , and expression of the dominant negative Ets-2 inhibited [FGF-] or constitutively active *induced* Xbra expression . Positive_regulation FGF2 MAP2K6 15564063 1341401 Inhibitors of signaling blocked up-regulation of the MMP-13 promoter by RUNX2 and FGF2 , and also *blocked* the activation of RUNX2 by [FGF2] . Positive_regulation FGF2 MMP28 9538225 497681 An inhibitor partially *suppressed* the release of [bFGF] , indicating that matrix degradation is at least partially involved in the IL-1 stimulated bFGF release even if increased production of bFGF is related to the release . Positive_regulation FGF2 MMP7 16494848 1528731 We show that the angiogenic factor [FGF-2] *induces* expression in human endothelial cells . Positive_regulation FGF2 MMP7 9538225 497697 An inhibitor partially *suppressed* the release of [bFGF] , indicating that matrix degradation is at least partially involved in the IL-1 stimulated bFGF release even if increased production of bFGF is related to the release . Positive_regulation FGF2 MSX1 20702560 2312645 Overexpression of was sufficient to *repress* [FGF] gene expression and cell proliferation , thereby promoting cardiomyocyte differentiation . Positive_regulation FGF2 NGFR 2155007 129331 Thus , the development of sympathetic neurons may involve a relay , in which [FGF] both initiates differentiation and *induces* the , which in turn controls further maturation and survival . Positive_regulation FGF2 PLAU 10051491 593148 Inhibition of with antibodies against u-PA or u-PAR and with u-PAR aODN *inhibit* the proliferative , chemotactic , and chemoinvasive activity of PDGF and [b-FGF] . Positive_regulation FGF2 PLAU 7860647 295256 [M1Q-bFGF] also *induced* an increase in cell associated activity only when added to the cell cultures in the presence of soluble heparin . Positive_regulation FGF2 PLAU 8148156 242612 The *inducing* activity of [M1Q-bFGF] was fully restored by the presence of soluble heparin in the culture medium . Positive_regulation FGF2 PLAU 8868466 389275 In contrast , tyrosine phosphorylation inhibitors and overexpression of a dominant negative TK- mutant of FGFR-1 abolish the *inducing* activity of [FGF-2] , indicating that FGFR and its TK activity are essential in mediating uPA induction . Positive_regulation FGF2 PLAU 8868466 389276 Accordingly , [FGF-2] *induces* up-regulation in Chinese hamster ovary cells transfected with wild-type FGFR-1 , -2 , -3 , or -4 but not with TK- FGFR-1 mutant . Positive_regulation FGF2 PLAU 9442043 483068 Although [FGF-2] and serum *induced* in proliferating myoblasts , their actions on cell-cell contact induced differentiating myoblasts differed dramatically . Positive_regulation FGF2 RARB 11230116 788664 In BAECs , the forced expression of RARalpha , but not or RARgamma , *enhanced* [FGF-2] production , whereas the RARalpha-dominant negative , Delta403 , blocked this effect . Positive_regulation FGF2 S100B 21073005 2345106 However , recent evidence suggests that might also *activate* [basic fibroblast growth factor] receptor 1 via prior binding to basic fibroblast growth factor . Positive_regulation FGF2 S100B 21693575 2446661 Here , we show that increases and/or *stabilizes* the binding of [basic fibroblast growth factor (bFGF)] to bFGF receptor 1 ( FGFR1 ) by interacting with bFGF , thereby enhancing FGFR1 activation and the mitogenic and anti-myogenic effects of FGFR1 . Positive_regulation FGF2 S100B 22276098 2545267 In high-density myoblast cultures *enhances* [basic fibroblast growth factor (bFGF)] receptor 1 ( FGFR1 ) signaling via binding to bFGF and blocks its canonical receptor , receptor for advanced glycation end-products ( RAGE ) , thereby stimulating proliferation and inhibiting differentiation . Positive_regulation FGF2 S100B 22276098 2545273 However , at relatively high doses , *stimulates* the mitogenic [bFGF/FGFR1] signaling in low-density myoblasts , provided bFGF is present . Positive_regulation FGF2 TMEM100 14688794 1192541 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF2 TMEM156 14688794 1192559 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF2 TMEM211 14688794 1192639 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF2 TMEM213 14688794 1192576 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF2 TNF 10369746 621781 We could demonstrate in HUAEC that stimulation with IL-1alpha- and *led* to the mRNA expression of [basic fibroblast growth factor (bFGF)] and vascular endothelial growth factor ( VEGF ) which are crucial in the process of angioneogenesis and atherosclerosis as well as of the granulocyte-colony stimulating factor ( G-CSF ) , granulocyte macrophage-colony stimulating factor ( GM-CSF ) and stem cell factor (SCF) which are main growth factors in haematopoiesis . Positive_regulation FGF2 TNF 12037401 949220 No changes in VCAM-1 expression were *induced* by TNF-alpha , IL-4 or [bFGF] , whereas both and IL-4 increased eotaxin release ( p < 0.05 ) . Positive_regulation FGF2 TNF 15646818 1349923 [bFGF] production *induced* by stimulation was also suppressed by FP , when the agent was added to cell cultures at more than 10 ( -7 ) M . Positive_regulation FGF2 TNF 1618817 191371 We have previously reported that *enhances* expression of interleukin-6 , collagenase , plasminogen activator inhibitor-1 , and [basic fibroblast growth factor] genes in human omental microvascular endothelial ( HOME ) cells in culture . Positive_regulation FGF2 TNF 16445521 1521664 The production of VEGF , [bFGF] and TGF-beta respectively was *enhanced* by both IL-1beta and . Positive_regulation FGF2 TNF 16445767 1517156 Of the pharmacological agents investigated , [bFGF] , IGF-1 , and beta-APN all *increased* collagen synthesis both in monocultures of fibroblasts and in cocultures of keratinocytes and fibroblasts . Positive_regulation FGF2 TNF 1655776 166371 Therefore , the biological effects of on HOME cells may be *mediated* , at least in part , by TNF-alpha induced [bFGF] . Positive_regulation FGF2 TNF 22492039 2583486 Furthermore , astrocytes in culture express high levels of [FGF-2] in response to IL-1ß , and IGF-1 in *response* to stimulation . Positive_regulation FGF2 TNF 7744816 306290 and [bFGF] *induction* of ROS production is mediated through flavonoid containing enzymes such as NADPH oxidase . Positive_regulation FGF2 TNF 8601593 351901 [bFGF] and VEGF165 enhanced of the u-PAR by 72 and 46 % , but itself also *increased* u-PAR in hMVEC by 30 % . Positive_regulation FGF2 TNF 9029130 413586 Production and release of [bFGF] is *induced* in a synergistic fashion by , IL-1beta , and IFN-gamma , and its release is further promoted by low cell density and by the serine proteases plasmin and thrombin . Positive_regulation FGF2 TNF 9199336 438917 A c-Jun antisense oligonucleotide significantly inhibited *dependent* [bFGF] production but did not affect the production of IL-8 and VEGF . Positive_regulation FGF2 TNF 9456251 484489 OSM , IL-1 and *induced* the transcriptional activation of a [bFGF] promoter reporter gene in parallel with the activation of an AP-1 reporter . Positive_regulation FGF2 TNFSF10 18313665 1886031 *stimulated* production of several cytokines , IL-8 , RANTES , MCP-1 and [bFGF] , and activation of caspases 1 and 8 was essential for this effect . Positive_regulation FGF20 EPHB2 10671553 667067 kinase inhibition *diminished* VEGF- , [FGF-] , and EGF promoted thymidine incorporation into DNA . Positive_regulation FGF20 EPHB2 11449001 835920 [FGF] *induced* sustained activation of extracellular signal regulated kinase ( ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation FGF20 EPHB2 17852407 1817901 [FGF] *induced* a transient activation of , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation FGF20 FGFBP1 15806171 1439263 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Positive_regulation FGF20 FGFBP1 17766586 1822797 Functionally , shuttles FGFs from binding sites in ECMs to cell surfaces and *enhances* [FGF] binding and signaling , whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation . Positive_regulation FGF20 IL1B 7662960 321777 To address the direct effects of FGF , we investigated whether [FGF] *induced* production of , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation FGF20 JAG1 19481073 2102461 [FGF] *induced* expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation FGF20 MAP2K6 11802165 906174 Here we show that in zebrafish , Sef functions as a feedback induced antagonist of *mediated* [FGF] signalling . Positive_regulation FGF20 MAP2K6 12468533 1055392 Overexpression of Ets-2 resulted in the induction of Xbra , and expression of the dominant negative Ets-2 inhibited [FGF-] or constitutively active *induced* Xbra expression . Positive_regulation FGF20 MSX1 20702560 2312646 Overexpression of was *sufficient* to repress [FGF] gene expression and cell proliferation , thereby promoting cardiomyocyte differentiation . Positive_regulation FGF20 NGFR 2155007 129332 Thus , the development of sympathetic neurons may involve a relay , in which [FGF] both initiates differentiation and *induces* the , which in turn controls further maturation and survival . Positive_regulation FGF20 TMEM100 14688794 1192710 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF20 TMEM156 14688794 1192728 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF20 TMEM211 14688794 1192808 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF20 TMEM213 14688794 1192745 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF21 EPHB2 10671553 667081 kinase inhibition *diminished* VEGF- , [FGF-] , and EGF promoted thymidine incorporation into DNA . Positive_regulation FGF21 EPHB2 11449001 835921 [FGF] *induced* sustained activation of extracellular signal regulated kinase ( ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation FGF21 EPHB2 17852407 1817905 [FGF] *induced* a transient activation of , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation FGF21 FGFBP1 15806171 1439266 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Positive_regulation FGF21 FGFBP1 17766586 1822798 Functionally , shuttles FGFs from binding sites in ECMs to cell surfaces and *enhances* [FGF] binding and signaling , whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation . Positive_regulation FGF21 IL1B 7662960 321780 To address the direct effects of FGF , we investigated whether [FGF] *induced* production of , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation FGF21 JAG1 19481073 2102463 [FGF] *induced* expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation FGF21 MAP2K6 11802165 906195 Here we show that in zebrafish , Sef functions as a feedback induced antagonist of *mediated* [FGF] signalling . Positive_regulation FGF21 MAP2K6 12468533 1055400 Overexpression of Ets-2 resulted in the induction of Xbra , and expression of the dominant negative Ets-2 inhibited [FGF-] or constitutively active *induced* Xbra expression . Positive_regulation FGF21 MSX1 20702560 2312647 Overexpression of was sufficient to *repress* [FGF] gene expression and cell proliferation , thereby promoting cardiomyocyte differentiation . Positive_regulation FGF21 NGFR 2155007 129333 Thus , the development of sympathetic neurons may involve a relay , in which [FGF] both initiates differentiation and *induces* the , which in turn controls further maturation and survival . Positive_regulation FGF21 TMEM100 14688794 1192879 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF21 TMEM156 14688794 1192897 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF21 TMEM211 14688794 1192977 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF21 TMEM213 14688794 1192914 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF22 EPHB2 10671553 667095 kinase inhibition *diminished* VEGF- , [FGF-] , and EGF promoted thymidine incorporation into DNA . Positive_regulation FGF22 EPHB2 11449001 835922 [FGF] *induced* sustained activation of extracellular signal regulated kinase ( ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation FGF22 EPHB2 17852407 1817909 [FGF] *induced* a transient activation of , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation FGF22 FGFBP1 15806171 1439269 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Positive_regulation FGF22 FGFBP1 17766586 1822799 Functionally , shuttles FGFs from binding sites in ECMs to cell surfaces and *enhances* [FGF] binding and signaling , whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation . Positive_regulation FGF22 IL1B 7662960 321783 To address the direct effects of FGF , we investigated whether [FGF] *induced* production of , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation FGF22 JAG1 19481073 2102465 [FGF] *induced* expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation FGF22 MAP2K6 11802165 906216 Here we show that in zebrafish , Sef functions as a feedback induced antagonist of *mediated* [FGF] signalling . Positive_regulation FGF22 MAP2K6 12468533 1055408 Overexpression of Ets-2 resulted in the induction of Xbra , and expression of the dominant negative Ets-2 inhibited [FGF-] or constitutively active *induced* Xbra expression . Positive_regulation FGF22 MSX1 20702560 2312648 Overexpression of was *sufficient* to repress [FGF] gene expression and cell proliferation , thereby promoting cardiomyocyte differentiation . Positive_regulation FGF22 NGFR 2155007 129334 Thus , the development of sympathetic neurons may involve a relay , in which [FGF] both initiates differentiation and *induces* the , which in turn controls further maturation and survival . Positive_regulation FGF22 TMEM100 14688794 1193048 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF22 TMEM156 14688794 1193066 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF22 TMEM211 14688794 1193146 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF22 TMEM213 14688794 1193083 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF23 EPHB2 10671553 667109 kinase inhibition *diminished* VEGF- , [FGF-] , and EGF promoted thymidine incorporation into DNA . Positive_regulation FGF23 EPHB2 11449001 835923 [FGF] *induced* sustained activation of extracellular signal regulated kinase ( ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation FGF23 EPHB2 17852407 1817913 [FGF] *induced* a transient activation of , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation FGF23 FGFBP1 15806171 1439272 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Positive_regulation FGF23 FGFBP1 17766586 1822800 Functionally , shuttles FGFs from binding sites in ECMs to cell surfaces and *enhances* [FGF] binding and signaling , whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation . Positive_regulation FGF23 IL1B 7662960 321786 To address the direct effects of FGF , we investigated whether [FGF] *induced* production of , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation FGF23 JAG1 19481073 2102467 [FGF] *induced* expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation FGF23 MAP2K6 11802165 906237 Here we show that in zebrafish , Sef functions as a feedback induced antagonist of *mediated* [FGF] signalling . Positive_regulation FGF23 MAP2K6 12468533 1055416 Overexpression of Ets-2 resulted in the induction of Xbra , and expression of the dominant negative Ets-2 inhibited [FGF-] or constitutively active *induced* Xbra expression . Positive_regulation FGF23 MSX1 20702560 2312649 Overexpression of was sufficient to *repress* [FGF] gene expression and cell proliferation , thereby promoting cardiomyocyte differentiation . Positive_regulation FGF23 NGFR 2155007 129335 Thus , the development of sympathetic neurons may involve a relay , in which [FGF] both initiates differentiation and *induces* the , which in turn controls further maturation and survival . Positive_regulation FGF23 TMEM100 14688794 1193217 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF23 TMEM156 14688794 1193235 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF23 TMEM211 14688794 1193315 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF23 TMEM213 14688794 1193252 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF3 CCND1 8622895 354600 No expression of [FGF3] and FGF4 was *detected* whereas both and EMS1 were expressed at higher level in tumours with amplifications . Positive_regulation FGF3 EPHB2 10671553 667123 kinase inhibition *diminished* VEGF- , [FGF-] , and EGF promoted thymidine incorporation into DNA . Positive_regulation FGF3 EPHB2 11449001 835924 [FGF] *induced* sustained activation of extracellular signal regulated kinase ( ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation FGF3 EPHB2 17852407 1817917 [FGF] *induced* a transient activation of , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation FGF3 FGFBP1 15806171 1439275 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Positive_regulation FGF3 FGFBP1 17766586 1822801 Functionally , shuttles FGFs from binding sites in ECMs to cell surfaces and *enhances* [FGF] binding and signaling , whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation . Positive_regulation FGF3 IL1B 7662960 321789 To address the direct effects of FGF , we investigated whether [FGF] *induced* production of , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation FGF3 JAG1 19481073 2102469 [FGF] *induced* expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation FGF3 MAP2K6 11802165 906258 Here we show that in zebrafish , Sef functions as a feedback induced antagonist of *mediated* [FGF] signalling . Positive_regulation FGF3 MAP2K6 12468533 1055424 Overexpression of Ets-2 resulted in the induction of Xbra , and expression of the dominant negative Ets-2 inhibited [FGF-] or constitutively active *induced* Xbra expression . Positive_regulation FGF3 MSX1 11023873 738395 In Msx1-deficient mice , tooth development arrests at the bud stage when is *required* for the expression of Bmp4 and [Fgf3] in the dental mesenchyme ( Bei , M. and Maas , R. ( 1998 ) Development 125 , 4325-4333 ) . Positive_regulation FGF3 MSX1 20702560 2312650 Overexpression of was *sufficient* to repress [FGF] gene expression and cell proliferation , thereby promoting cardiomyocyte differentiation . Positive_regulation FGF3 NGFR 2155007 129336 Thus , the development of sympathetic neurons may involve a relay , in which [FGF] both initiates differentiation and *induces* the , which in turn controls further maturation and survival . Positive_regulation FGF3 TMEM100 14688794 1193386 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF3 TMEM156 14688794 1193404 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF3 TMEM211 14688794 1193484 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF3 TMEM213 14688794 1193421 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF4 CCND1 8622895 354602 No expression of FGF3 and [FGF4] was *detected* whereas both and EMS1 were expressed at higher level in tumours with amplifications . Positive_regulation FGF4 EPHB2 10671553 667137 kinase inhibition *diminished* VEGF- , [FGF-] , and EGF promoted thymidine incorporation into DNA . Positive_regulation FGF4 EPHB2 11449001 835925 [FGF] *induced* sustained activation of extracellular signal regulated kinase ( ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation FGF4 EPHB2 17852407 1817921 [FGF] *induced* a transient activation of , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation FGF4 FGFBP1 15806171 1439278 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Positive_regulation FGF4 FGFBP1 17766586 1822802 Functionally , shuttles FGFs from binding sites in ECMs to cell surfaces and *enhances* [FGF] binding and signaling , whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation . Positive_regulation FGF4 IL1B 7662960 321792 To address the direct effects of FGF , we investigated whether [FGF] *induced* production of , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation FGF4 JAG1 19481073 2102471 [FGF] *induced* expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation FGF4 MAP2K6 11802165 906279 Here we show that in zebrafish , Sef functions as a feedback induced antagonist of *mediated* [FGF] signalling . Positive_regulation FGF4 MAP2K6 12468533 1055432 Overexpression of Ets-2 resulted in the induction of Xbra , and expression of the dominant negative Ets-2 inhibited [FGF-] or constitutively active *induced* Xbra expression . Positive_regulation FGF4 MSX1 20702560 2312651 Overexpression of was sufficient to *repress* [FGF] gene expression and cell proliferation , thereby promoting cardiomyocyte differentiation . Positive_regulation FGF4 MSX1 9477322 486881 BMP4 induced the expression of both Msx1 and Msx2 genes in sutural tissue , while [FGF4] *induced* only . Positive_regulation FGF4 NGFR 2155007 129337 Thus , the development of sympathetic neurons may involve a relay , in which [FGF] both initiates differentiation and *induces* the , which in turn controls further maturation and survival . Positive_regulation FGF4 TMEM100 14688794 1193555 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF4 TMEM156 14688794 1193573 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF4 TMEM211 14688794 1193653 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF4 TMEM213 14688794 1193590 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF5 EPHB2 10671553 667151 kinase inhibition *diminished* VEGF- , [FGF-] , and EGF promoted thymidine incorporation into DNA . Positive_regulation FGF5 EPHB2 11449001 835926 [FGF] *induced* sustained activation of extracellular signal regulated kinase ( ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation FGF5 EPHB2 17852407 1817925 [FGF] *induced* a transient activation of , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation FGF5 FAS 23232116 2731633 The expression of [Fgf5] , an epiblast marker , was *diminished* by inhibition of signaling using the caspase-8 and -3 blocking peptides , IETD and DEVD , respectively . Positive_regulation FGF5 FGFBP1 15806171 1439281 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Positive_regulation FGF5 FGFBP1 17766586 1822803 Functionally , shuttles FGFs from binding sites in ECMs to cell surfaces and *enhances* [FGF] binding and signaling , whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation . Positive_regulation FGF5 IL1B 7662960 321795 To address the direct effects of FGF , we investigated whether [FGF] *induced* production of , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation FGF5 JAG1 19481073 2102473 [FGF] *induced* expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation FGF5 MAP2K6 11802165 906300 Here we show that in zebrafish , Sef functions as a feedback induced antagonist of *mediated* [FGF] signalling . Positive_regulation FGF5 MAP2K6 12468533 1055440 Overexpression of Ets-2 resulted in the induction of Xbra , and expression of the dominant negative Ets-2 inhibited [FGF-] or constitutively active *induced* Xbra expression . Positive_regulation FGF5 MSX1 20702560 2312652 Overexpression of was *sufficient* to repress [FGF] gene expression and cell proliferation , thereby promoting cardiomyocyte differentiation . Positive_regulation FGF5 NGFR 2155007 129338 Thus , the development of sympathetic neurons may involve a relay , in which [FGF] both initiates differentiation and *induces* the , which in turn controls further maturation and survival . Positive_regulation FGF5 TMEM100 14688794 1193724 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF5 TMEM156 14688794 1193742 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF5 TMEM211 14688794 1193822 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF5 TMEM213 14688794 1193759 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF6 EPHB2 10671553 667165 kinase inhibition *diminished* VEGF- , [FGF-] , and EGF promoted thymidine incorporation into DNA . Positive_regulation FGF6 EPHB2 11449001 835927 [FGF] *induced* sustained activation of extracellular signal regulated kinase ( ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation FGF6 EPHB2 17852407 1817929 [FGF] *induced* a transient activation of , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation FGF6 FGFBP1 15806171 1439284 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Positive_regulation FGF6 FGFBP1 17766586 1822804 Functionally , shuttles FGFs from binding sites in ECMs to cell surfaces and *enhances* [FGF] binding and signaling , whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation . Positive_regulation FGF6 IL1B 7662960 321798 To address the direct effects of FGF , we investigated whether [FGF] *induced* production of , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation FGF6 JAG1 19481073 2102475 [FGF] *induced* expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation FGF6 MAP2K6 11802165 906321 Here we show that in zebrafish , Sef functions as a feedback induced antagonist of *mediated* [FGF] signalling . Positive_regulation FGF6 MAP2K6 12468533 1055448 Overexpression of Ets-2 resulted in the induction of Xbra , and expression of the dominant negative Ets-2 inhibited [FGF-] or constitutively active *induced* Xbra expression . Positive_regulation FGF6 MSX1 20702560 2312653 Overexpression of was sufficient to *repress* [FGF] gene expression and cell proliferation , thereby promoting cardiomyocyte differentiation . Positive_regulation FGF6 NGFR 2155007 129339 Thus , the development of sympathetic neurons may involve a relay , in which [FGF] both initiates differentiation and *induces* the , which in turn controls further maturation and survival . Positive_regulation FGF6 TMEM100 14688794 1193893 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF6 TMEM156 14688794 1193911 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF6 TMEM211 14688794 1193991 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF6 TMEM213 14688794 1193928 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF7 CD14 12438323 1016554 Induction of [keratinocyte growth factor] 1 Expression by lipopolysaccharide is *regulated* by and toll-like receptors 2 and 4 . Positive_regulation FGF7 EPHB2 10671553 667179 kinase inhibition *diminished* VEGF- , [FGF-] , and EGF promoted thymidine incorporation into DNA . Positive_regulation FGF7 EPHB2 11449001 835928 [FGF] *induced* sustained activation of extracellular signal regulated kinase ( ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation FGF7 EPHB2 17852407 1817933 [FGF] *induced* a transient activation of , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation FGF7 FGFBP1 15806171 1439287 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Positive_regulation FGF7 FGFBP1 17766586 1822805 Functionally , shuttles FGFs from binding sites in ECMs to cell surfaces and *enhances* [FGF] binding and signaling , whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation . Positive_regulation FGF7 IL1B 12697038 1081261 Finally , we showed that , but not oestradiol or other oestrogen receptor ligands , *caused* a dose related [FGF7] release . Positive_regulation FGF7 IL1B 7662960 321801 To address the direct effects of FGF , we investigated whether [FGF] *induced* production of , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation FGF7 JAG1 19481073 2102477 [FGF] *induced* expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation FGF7 MAP2K6 11802165 906342 Here we show that in zebrafish , Sef functions as a feedback induced antagonist of *mediated* [FGF] signalling . Positive_regulation FGF7 MAP2K6 12468533 1055456 Overexpression of Ets-2 resulted in the induction of Xbra , and expression of the dominant negative Ets-2 inhibited [FGF-] or constitutively active *induced* Xbra expression . Positive_regulation FGF7 MSX1 20702560 2312654 Overexpression of was sufficient to *repress* [FGF] gene expression and cell proliferation , thereby promoting cardiomyocyte differentiation . Positive_regulation FGF7 NGFR 2155007 129340 Thus , the development of sympathetic neurons may involve a relay , in which [FGF] both initiates differentiation and *induces* the , which in turn controls further maturation and survival . Positive_regulation FGF7 TMEM100 14688794 1194062 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF7 TMEM156 14688794 1194080 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF7 TMEM211 14688794 1194160 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF7 TMEM213 14688794 1194097 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF8 EPHB2 10671553 667193 kinase inhibition *diminished* VEGF- , [FGF-] , and EGF promoted thymidine incorporation into DNA . Positive_regulation FGF8 EPHB2 11449001 835929 [FGF] *induced* sustained activation of extracellular signal regulated kinase ( ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation FGF8 EPHB2 12766772 1094162 Here we show that during chick , mouse and zebrafish limb/fin development , a known regulator , Mkp3 , is *induced* in the mesenchyme by [fibroblast growth factor 8 (FGF8)] signalling , through the PI3K/Akt pathway . Positive_regulation FGF8 EPHB2 17852407 1817937 [FGF] *induced* a transient activation of , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation FGF8 FGFBP1 15806171 1439290 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Positive_regulation FGF8 FGFBP1 17766586 1822806 Functionally , shuttles FGFs from binding sites in ECMs to cell surfaces and *enhances* [FGF] binding and signaling , whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation . Positive_regulation FGF8 IL1B 7662960 321804 To address the direct effects of FGF , we investigated whether [FGF] *induced* production of , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation FGF8 JAG1 19481073 2102479 [FGF] *induced* expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation FGF8 MAP2K6 11802165 906363 Here we show that in zebrafish , Sef functions as a feedback induced antagonist of *mediated* [FGF] signalling . Positive_regulation FGF8 MAP2K6 12468533 1055464 Overexpression of Ets-2 resulted in the induction of Xbra , and expression of the dominant negative Ets-2 inhibited [FGF-] or constitutively active *induced* Xbra expression . Positive_regulation FGF8 MSX1 15691759 1371428 and Pax3 cooperate to *mediate* [FGF8] and WNT signals during Xenopus neural crest induction . Positive_regulation FGF8 MSX1 20702560 2312655 Overexpression of was *sufficient* to repress [FGF] gene expression and cell proliferation , thereby promoting cardiomyocyte differentiation . Positive_regulation FGF8 NGFR 2155007 129341 Thus , the development of sympathetic neurons may involve a relay , in which [FGF] both initiates differentiation and *induces* the , which in turn controls further maturation and survival . Positive_regulation FGF8 TMEM100 14688794 1194231 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF8 TMEM156 14688794 1194249 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF8 TMEM211 14688794 1194329 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF8 TMEM213 14688794 1194266 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF8 ZIC2 17948241 1844473 We further show that [FGF8] can *induce* the expression of , which is normally expressed at the midline and is required in vivo for hemispheric cleavage , suggesting that FGF signaling may stimulate dorsal midline development by inducing Zic2 expression . Positive_regulation FGF9 EPHB2 10671553 667207 kinase inhibition *diminished* VEGF- , [FGF-] , and EGF promoted thymidine incorporation into DNA . Positive_regulation FGF9 EPHB2 11449001 835930 [FGF] *induced* sustained activation of extracellular signal regulated kinase ( ) in lens cells , an event necessary and sufficient to increase gap junctional coupling . Positive_regulation FGF9 EPHB2 17852407 1817941 [FGF] *induced* a transient activation of , but not Akt , which was inhibited by an inhibitor of MEK , the upstream kinase of ERK , but not by inhibitors of PI3K/Akt ( LY294002 ) , epidermal growth factor receptor ( EGFR , AG1478 ) , and Src ( PP2 ) . Positive_regulation FGF9 FGFBP1 15806171 1439293 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Positive_regulation FGF9 FGFBP1 17766586 1822807 Functionally , shuttles FGFs from binding sites in ECMs to cell surfaces and *enhances* [FGF] binding and signaling , whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation . Positive_regulation FGF9 IL1B 7662960 321807 To address the direct effects of FGF , we investigated whether [FGF] *induced* production of , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation FGF9 JAG1 19481073 2102481 [FGF] *induced* expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation FGF9 MAP2K6 11802165 906384 Here we show that in zebrafish , Sef functions as a feedback induced antagonist of *mediated* [FGF] signalling . Positive_regulation FGF9 MAP2K6 12468533 1055472 Overexpression of Ets-2 resulted in the induction of Xbra , and expression of the dominant negative Ets-2 inhibited [FGF-] or constitutively active *induced* Xbra expression . Positive_regulation FGF9 MSX1 20702560 2312656 Overexpression of was sufficient to *repress* [FGF] gene expression and cell proliferation , thereby promoting cardiomyocyte differentiation . Positive_regulation FGF9 NGFR 2155007 129342 Thus , the development of sympathetic neurons may involve a relay , in which [FGF] both initiates differentiation and *induces* the , which in turn controls further maturation and survival . Positive_regulation FGF9 TMEM100 14688794 1194400 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF9 TMEM156 14688794 1194418 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF9 TMEM211 14688794 1194498 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGF9 TMEM213 14688794 1194435 The XFLRT3 forms a complex with FGF receptors and *promotes* [FGF] signalling . Positive_regulation FGFBP1 CTNNB1 14678957 1179005 *Up-regulation* of [fibroblast growth factor binding protein] , by during colon carcinogenesis . Positive_regulation FGFBP1 CTNNB1 14678957 1179008 Also , in cell culture studies [FGF-BP] is *induced* by through direct activation of the FGF-BP gene promoter . Positive_regulation FGFBP1 EGF 10753873 682058 *Induction* of the angiogenic modulator [fibroblast growth factor binding protein] by is mediated through both MEK/ERK and p38 signal transduction pathways . Positive_regulation FGFBP1 EGF 10753873 682075 These results demonstrate that *induction* of [FGF-BP] occurs selectively through dual activation of the stress activated p38 and the MEK/extracellular signal regulated kinase mitogen activated protein kinase pathways , which ultimately leads to activation of the promoter through AP-1 and CCAAT/enhancer binding protein sites . Positive_regulation FGFBP1 EGF 12670924 1076222 DNA binding of the LIP and LAP containing c complex and the b complex in the presence of EGF was modulated by inhibition of p38 mitogen activated protein kinase , suggesting a role for these complexes in the *induction* of the [FGF-BP] promoter . Positive_regulation FGFBP1 KLF5 19668233 2150665 Furthermore , we demonstrated that binds and *activates* the [FGF-BP] promoter through a GC box by luciferase reporter , oligo pull down and chromatin immunoprecipitation ( ChIP ) assays . Positive_regulation FGFR1 ANGPT1 17297442 1771892 Conditional activation of [FGFR1] in the prostate epithelium *induces* angiogenesis with concomitant differential regulation of and Ang-2 . Positive_regulation FGFR1 CCND1 18665077 1943052 Inhibition of , known to be induced by insulinlike growth factor I , epidermal growth factor , and FGF2 , *resulted* in an inhibition of [FGFR1-IIIc] expression , whereas FGFR1-IIIb expression was enhanced . Positive_regulation FGFR1 EFNB1 10611251 656195 Here , we report that when we used ectopically expressed proteins , we found that an activated [fibroblast growth factor (FGF) receptor] associated with and *induced* the phosphorylation of on tyrosine . Positive_regulation FGFR1 EPHB2 11031252 786057 The expression of a dominant negative FGFR1 did not reduce ERK-1/2 activation by the HMW FGF-2 , suggesting that activation does not *require* [FGFR] activity . Positive_regulation FGFR1 EPHB2 11850809 913018 bFGF-induces phosphorylation of [FGFr 1] and *activation* of in ESFT cells that die when exposed to bFGF . Positive_regulation FGFR1 EPHB2 23405013 2743652 *mediated* phosphorylation of [fibroblast growth factor receptor 1] on Ser777 inhibits signaling . Positive_regulation FGFR1 EPHB2 23571107 2804195 The ras-GTPase activity of neurofibromin restrains *dependent* [FGFR] signaling during endochondral bone formation . Positive_regulation FGFR1 EPHB2 8264585 246903 Activation of [FGFR-1] in transfected L6 myoblasts *induced* far stronger phosphorylation of phospholipase C gamma , SHC , and proteins than could activation of FGFR-4 in L6 cells , and only FGFR-1 activation induced tyrosine phosphorylation of a characteristic 80-kD protein . Positive_regulation FGFR1 IL1B 16718462 1584945 Further , these data identify a novel function of C3d as an inhibitor of NCAM induced [FGFR] activity and of induced MAPK *activation* in beta cells . Positive_regulation FGFR1 S100B 21693575 2446662 Here , we show that increases and/or stabilizes the binding of basic fibroblast growth factor (bFGF) to bFGF receptor 1 ( FGFR1 ) by interacting with bFGF , thereby *enhancing* [FGFR1] activation and the mitogenic and anti-myogenic effects of FGFR1 . Positive_regulation FGFR1 S100B 22276098 2545274 However , at relatively high doses , *stimulates* the mitogenic [bFGF/FGFR1] signaling in low-density myoblasts , provided bFGF is present . Positive_regulation FGFR2 CTGF 23142580 2707366 We ascertained that FGFR2 bound to CCN2 and that the binding of [FGFR2] to FGF2 and FGF4 was *enhanced* by CCN2 . and FGF2 had a collaborative effect on the phosphorylation of ERK and the differentiation of osteoblastic cells . Positive_regulation FGFR2 EFNB1 10611251 656196 Here , we report that when we used ectopically expressed proteins , we found that an activated [fibroblast growth factor (FGF) receptor] associated with and *induced* the phosphorylation of on tyrosine . Positive_regulation FGFR2 EPHB2 11031252 786058 The expression of a dominant negative FGFR1 did not reduce ERK-1/2 activation by the HMW FGF-2 , suggesting that activation does not *require* [FGFR] activity . Positive_regulation FGFR2 EPHB2 23571107 2804196 The ras-GTPase activity of neurofibromin restrains *dependent* [FGFR] signaling during endochondral bone formation . Positive_regulation FGFR2 IL1B 16718462 1584948 Further , these data identify a novel function of C3d as an inhibitor of NCAM induced [FGFR] activity and of induced MAPK *activation* in beta cells . Positive_regulation FGFR2 IL1B 16827730 1586669 In cell culture serum , lipopolysaccharide and pro-inflammatory cytokines , and tumour necrosis factor-alpha significantly *induced* [KGFR] protein receptor expression , but HGFR expression was only induced by serum . Positive_regulation FGFR2 TP63 12692135 1100005 We thus propose that a complex differentially *regulates* [FGFR-2] expression by supporting alternative splicing of the K-SAM isoform of FGFR-2 . Positive_regulation FGFR3 ALDH2 19356968 2081135 These observations indicate that high EtOH , [AcH] and low acetate in the blood of ALDH2 KO are *due* to the deficient effect of enzyme activity . Positive_regulation FGFR3 EFNB1 10611251 656197 Here , we report that when we used ectopically expressed proteins , we found that an activated [fibroblast growth factor (FGF) receptor] associated with and *induced* the phosphorylation of on tyrosine . Positive_regulation FGFR3 EPHB2 11031252 786059 The expression of a dominant negative FGFR1 did not reduce ERK-1/2 activation by the HMW FGF-2 , suggesting that activation does not *require* [FGFR] activity . Positive_regulation FGFR3 EPHB2 23571107 2804197 The ras-GTPase activity of neurofibromin restrains *dependent* [FGFR] signaling during endochondral bone formation . Positive_regulation FGFR3 IL1B 16122837 1454395 ( 10 ng/ml ) *increased* [ACh] release ( 125 % ) but did not change other parameters of NC . Positive_regulation FGFR3 IL1B 16718462 1584951 Further , these data identify a novel function of C3d as an inhibitor of NCAM induced [FGFR] activity and of induced MAPK *activation* in beta cells . Positive_regulation FGFR3 LYNX1 17286989 1747334 SLURP-1 reportedly binds to alpha7 nAChRs and enhances the amplitude of macroscopic currents *induced* by [ACh] , leading to facilitation of apoptosis , whereas binds to alpha3 nAChRs and prevents apoptosis . Positive_regulation FGFR3 TNF 1847684 153505 5. Inhibition of PL-A2 activity by appropriate drugs markedly diminished *induced* delta [4Ach] release and resulted also in a strong decrease in TNF induced cytotoxicity . Positive_regulation FGFR3 TNF 1847684 153507 6. Other drugs , including serine protease inhibitors , which strongly inhibit TNF induced cytotoxicity , also decreased the *induced* delta [4Ach] release , whereas LiCl potentiated both TNF mediated effects . Positive_regulation FGFR3 TNF 23142559 2722763 In A549 cells , *increased* the release of CXCL8 and [ACh] and the expression of the subtype 3 MR ( M3R ) . Positive_regulation FGFR3 TNF 7511177 250042 alpha *induction* of U1 , [ACH-2] , and OM-10.1 cultures resulted in an initial accumulation of multiply spliced HIV-1 RNA followed by a transition to the larger unspliced viral RNA transcripts . Positive_regulation FGFR3 TNF 8327469 223447 Thalidomide inhibition of virus replication in the phorbol myristate acetate- and recombinant *stimulated* T-cell line [ACH-2] is not observed . Positive_regulation FGFR4 EFNB1 10611251 656198 Here , we report that when we used ectopically expressed proteins , we found that an activated [fibroblast growth factor (FGF) receptor] associated with and *induced* the phosphorylation of on tyrosine . Positive_regulation FGFR4 EPHB2 11031252 786060 The expression of a dominant negative FGFR1 did not reduce ERK-1/2 activation by the HMW FGF-2 , suggesting that activation does not *require* [FGFR] activity . Positive_regulation FGFR4 EPHB2 23571107 2804198 The ras-GTPase activity of neurofibromin restrains *dependent* [FGFR] signaling during endochondral bone formation . Positive_regulation FGFR4 IL1B 16718462 1584954 Further , these data identify a novel function of C3d as an inhibitor of NCAM induced [FGFR] activity and of induced MAPK *activation* in beta cells . Positive_regulation FGFR4 TMEM100 17711860 1801046 We show that betaKlotho , a single-pass highly expressed in liver and fat , induced ERK1/2 phosphorylation in response to FGF19 treatment and significantly *increased* the interactions between FGF19 and [FGFR4] . Positive_regulation FGFR4 TMEM156 17711860 1801064 We show that betaKlotho , a single-pass highly expressed in liver and fat , induced ERK1/2 phosphorylation in response to FGF19 treatment and significantly *increased* the interactions between FGF19 and [FGFR4] . Positive_regulation FGFR4 TMEM211 17711860 1801144 We show that betaKlotho , a single-pass highly expressed in liver and fat , induced ERK1/2 phosphorylation in response to FGF19 treatment and significantly *increased* the interactions between FGF19 and [FGFR4] . Positive_regulation FGFR4 TMEM213 17711860 1801081 We show that betaKlotho , a single-pass highly expressed in liver and fat , induced ERK1/2 phosphorylation in response to FGF19 treatment and significantly *increased* the interactions between FGF19 and [FGFR4] . Positive_regulation FGG ANGPT1 19052021 2047392 [Fibrinogen] *induced* the production of interleukin 6 (IL6) , interleukin 8 (IL8) , monocyte chemoattractant protein-1 , vascular endothelial growth factor , and type I collagen , but not proliferation or intercellular adhesion molecule-1 expression . Positive_regulation FGL2 TNF 23432784 2822969 *upregulates* [Fgl2] expression in rat myocardial ischemia/reperfusion injury . Positive_regulation FGL2 TNF 23432784 2822970 This study investigates whether *regulates* [fibrinogen-like protein 2 (fgl2)] expression , a procoagulant resulting in the formation of fibrin-rich microthrombus in MI/R injury . Positive_regulation FGR TNF 24395887 2900264 Using a model in which pregnant rats are administered low-dose lipopolysaccharide (LPS) on gestational days 13.5-16.5 , we show that abnormal inflammation resulted in [FGR] *mediated* by . Positive_regulation FGR TNF 8867673 344816 In fact , only in the presence of Mg2+ , but not in the absence of divalent cations or in the presence of Ca2+ alone , *increased* [p58c-fgr] and p53/56lyn kinase activities ; Positive_regulation FHL1 CDKN1A 19139564 2032182 Casein kinase 1delta , but not the TGF-beta receptor , was required for the FHL mediated TGF-beta-like responses , including increased phosphorylation of Smad2/3 , interaction of Smad2/3 and Smad4 , nuclear accumulation of Smad proteins , *activation* of the tumor suppressor gene , and repression of the oncogene c-myc. [FHL1-3] inhibited anchorage dependent and -independent growth of a human hepatoma cell line in vitro and tumor formation in nude mice . Positive_regulation FHL1 CRK 23938460 2895760 The expression of CFH by cSCC cells was upregulated by IFN-? and the basal CFH and [FHL-1] expression was *dependent* on extracellular signal regulated kinase ( ERK ) 1/2 and signaling . Positive_regulation FHL1 FFAR1 21097709 2357749 We demonstrate that HY5 physically interacts with FHY3/FAR1 through their respective DNA binding domains and negatively regulates *activated* [FHY1/FHL] expression under far red light . Positive_regulation FHL1 FFAR2 21097709 2357751 We demonstrate that HY5 physically interacts with FHY3/FAR1 through their respective DNA binding domains and negatively regulates *activated* [FHY1/FHL] expression under far red light . Positive_regulation FHL1 FFAR3 21097709 2357750 We demonstrate that HY5 physically interacts with FHY3/FAR1 through their respective DNA binding domains and negatively regulates *activated* [FHY1/FHL] expression under far red light . Positive_regulation FHL1 FFAR4 21097709 2357748 We demonstrate that HY5 physically interacts with FHY3/FAR1 through their respective DNA binding domains and negatively regulates *activated* [FHY1/FHL] expression under far red light . Positive_regulation FHL1 HOXD13 18758158 1956610 This study aimed to verify whether directly *regulates* [skeletal muscle LIM protein 1] ( Fhl1 ) expression during limb development in rat embryo , which will serve as a basis for comprehending etiological research of idiopathic CCF . Positive_regulation FHL1 HOXD13 18758158 1956613 Thus , directly *regulates* [Fhl1] expression in rat embryo . Positive_regulation FHL1 HOXD13 18758158 1956615 These findings suggest that may *regulate* the expression of [FHL1] in the development of idiopathic CCF . Positive_regulation FHL1 MYLIP 23628900 2804962 Transfection of pre-miR in hypoxic conditions *led* to increased expression of HIF-1a and [Fhl-1] rather than abolishing hypoxia induced HIF-1a and Fhl-1 , as was expected , and promoted the entry of cells into the S phase and enhanced PASMC proliferation . Positive_regulation FHL1 SDPR 18422756 1915235 In addition , global expression analysis indicates that [Fhl1] *induced* expression of in Src transformed cells . Positive_regulation FHL1 TLX1 18073142 1861928 In luciferase reporter assays , mediated repression rather than *activation* of the [FHL1] gene promoter and the magnitude of this effect was strongly influenced by the cellular background . Positive_regulation FIGF IL1B 17929249 1866351 RT-PCR and Western blot analyses confirmed decreased expression of [VEGF-D] in *response* to . Positive_regulation FIGF IL1B 17929249 1866358 This is the first report to indicate inhibition of [VEGF-D] gene expression in *response* to in cardiac microvascular endothelial cells , a cell type of central interest in angiogenesis . Positive_regulation FIS1 PGC 22769563 2659821 IL-6 over-expression in pre-cachectic mice accelerated body weight loss and muscle wasting , without reducing mitochondrial content , while and Mfn1/Mfn2 protein expression was suppressed and [FIS1] protein expression *induced* . Positive_regulation FKBP5 EPHB2 21508957 2428628 Dynamic interaction enhances NMDA receptor current , *induces* [Fkbp5] gene expression and enhances behavioural signatures of anxiety . Positive_regulation FKBP5 TNF 18439101 1900419 Stimulation of neutrophils with and GM-CSF *caused* phosphorylation of [p54] or p46 JNK or both . Positive_regulation FLG ACD 17045653 1666578 Using a Rap1-GTP pull-down assay , we found that [FLG] stimulation , but not LPS , of avian heterophils *induced* a rapid and transient activation . Positive_regulation FLG ACD 17045653 1666599 We show here that [FLG] stimulation of heterophils *induces* the phosphorylation of . Positive_regulation FLG AOC2 20711260 2306510 Furthermore , *increased* the level of [filaggrin] in cultured keratinocytes , and in the granular layer of mouse skin . Positive_regulation FLG BLMH 19286660 2063844 Neutral cysteine protease is *essential* for the breakdown of deiminated [filaggrin] into amino acids . Positive_regulation FLG BMP1 21079999 2354837 We present evidence that signaling *regulates* [filaggrin] expression in the epidermis . Positive_regulation FLG BMP10 21079999 2354845 We present evidence that signaling *regulates* [filaggrin] expression in the epidermis . Positive_regulation FLG BMP15 21079999 2354838 We present evidence that signaling *regulates* [filaggrin] expression in the epidermis . Positive_regulation FLG BMP2 21079999 2354839 We present evidence that signaling *regulates* [filaggrin] expression in the epidermis . Positive_regulation FLG BMP3 21079999 2354840 We present evidence that signaling *regulates* [filaggrin] expression in the epidermis . Positive_regulation FLG BMP4 21079999 2354841 We present evidence that signaling *regulates* [filaggrin] expression in the epidermis . Positive_regulation FLG BMP5 21079999 2354842 We present evidence that signaling *regulates* [filaggrin] expression in the epidermis . Positive_regulation FLG BMP6 21079999 2354843 We present evidence that signaling *regulates* [filaggrin] expression in the epidermis . Positive_regulation FLG BMP7 21079999 2354844 We present evidence that signaling *regulates* [filaggrin] expression in the epidermis . Positive_regulation FLG CA2 11286634 799875 Cell counting , 5-bromo-2'-deoxyuridine incorporation , and western blot analysis showed that fibroblast growth factor 10 , similarly to keratinocyte growth factor , not only is a potent mitogen for human keratinocytes , but also promotes the expression of both early differentiation markers K1 and K10 and late differentiation marker [filaggrin] in *response* to the signal , and seems to sustain the proliferative activity in suprabasal stratified cells . Positive_regulation FLG CA2 18648826 2078885 Stimulation by further *increased* expression of [filaggrin] and Kdap , but had no effect on the level of involucrin expression . Positive_regulation FLG CASP14 21654840 2489830 is *required* for [filaggrin] degradation to natural moisturizing factors in the skin . Positive_regulation FLG CDKN1A 18385759 1944165 Furthermore , a cyclin dependent kinase inhibitor downstream of S100/A11 , was *required* for calcium mediated induction of HBD-3 and [FLG] . Positive_regulation FLG EGF 18648826 2078886 *stimulated* expression of [filaggrin] only . Positive_regulation FLG FGF1 2554327 120756 *stimulated* tyrosine kinase activity of [FLG] in vitro and in living cells , suggesting that FLG encodes the membrane receptor for aFGF . Positive_regulation FLG HRAS 17045653 1666546 In the present study , we investigated the *role* of in [FLG-] and LPS mediated signaling in ERK activation in chicken heterophils . Positive_regulation FLG IL31 22177328 2543131 *regulates* differentiation and [filaggrin] expression in human organotypic skin models . Positive_regulation FLG KRAS 17045653 1666547 In the present study , we investigated the *role* of in [FLG-] and LPS mediated signaling in ERK activation in chicken heterophils . Positive_regulation FLG NRAS 17045653 1666548 In the present study , we investigated the *role* of in [FLG-] and LPS mediated signaling in ERK activation in chicken heterophils . Positive_regulation FLG PCSK5 18385762 1944173 Topical also *enhanced* the expression of involucrin , loricrin , [filaggrin] , and keratin 5 in intact murine epidermis . Positive_regulation FLG POT1 17045653 1666576 Using a Rap1-GTP pull-down assay , we found that [FLG] stimulation , but not LPS , of avian heterophils *induced* a rapid and transient activation . Positive_regulation FLG POT1 17045653 1666597 We show here that [FLG] stimulation of heterophils *induces* the phosphorylation of . Positive_regulation FLG POU3F2 20967260 2338412 When Brn2 was overexpressed by adenoviral transduction , *led* to increased expression of the differentiation related genes involucrin , [filaggrin] , and loricrin in addition to inhibition of their proliferation . Positive_regulation FLG PPARG 15245430 1270929 Although activators *stimulated* loricrin and [filaggrin] expression in wild-type animals , however , in PPAR-gamma-deficient mice no effect was observed indicating that the stimulation of differentiation by PPAR-gamma activators is mediated by PPAR-gamma . Positive_regulation FLG RAD50 17045653 1666579 Using a Rap1-GTP pull-down assay , we found that [FLG] stimulation , but not LPS , of avian heterophils *induced* a rapid and transient activation . Positive_regulation FLG RAD50 17045653 1666600 We show here that [FLG] stimulation of heterophils *induces* the phosphorylation of . Positive_regulation FLG SIK1 9405638 470071 Overexpression of in EMK cells *results* in increased expression of [filaggrin] during differentiation , supporting a role for Sik in differentiation . Positive_regulation FLG SIK2 9405638 470072 Overexpression of in EMK cells *results* in increased expression of [filaggrin] during differentiation , supporting a role for Sik in differentiation . Positive_regulation FLG SIK3 9405638 470073 Overexpression of in EMK cells *results* in increased expression of [filaggrin] during differentiation , supporting a role for Sik in differentiation . Positive_regulation FLG TERF1 17045653 1666573 Using a Rap1-GTP pull-down assay , we found that [FLG] stimulation , but not LPS , of avian heterophils *induced* a rapid and transient activation . Positive_regulation FLG TERF1 17045653 1666594 We show here that [FLG] stimulation of heterophils *induces* the phosphorylation of . Positive_regulation FLG TERF2 17045653 1666574 Using a Rap1-GTP pull-down assay , we found that [FLG] stimulation , but not LPS , of avian heterophils *induced* a rapid and transient activation . Positive_regulation FLG TERF2 17045653 1666595 We show here that [FLG] stimulation of heterophils *induces* the phosphorylation of . Positive_regulation FLG TERF2IP 17045653 1666577 Using a Rap1-GTP pull-down assay , we found that [FLG] stimulation , but not LPS , of avian heterophils *induced* a rapid and transient activation . Positive_regulation FLG TERF2IP 17045653 1666598 We show here that [FLG] stimulation of heterophils *induces* the phosphorylation of . Positive_regulation FLG TGM1 7907550 250413 Since the [filaggrin] linker segment peptide was efficiently conjugated with P-cystatin alpha and was *mediated* by in the presence of Ca2+ ions , filaggrin is a candidate for the glutamine-rich linkage protein to conjugate with lysine-rich P-cystatin alpha . Positive_regulation FLG TINF2 17045653 1666575 Using a Rap1-GTP pull-down assay , we found that [FLG] stimulation , but not LPS , of avian heterophils *induced* a rapid and transient activation . Positive_regulation FLG TINF2 17045653 1666596 We show here that [FLG] stimulation of heterophils *induces* the phosphorylation of . Positive_regulation FLG TMEM37 19825551 2009235 While high doses of either microbe associated molecular pattern ( MAMP ) elicit a late response that includes activation of senescence processes , SA-dependent secretory pathway genes and expression are substantially *induced* only by [Flg22] . Positive_regulation FLG2 TNF 23432784 2822972 *induced* [flg2] in CMECs mediates the formation of fibrin-rich microthrombus , which may be one of the mechanisms of microvascular dysfunction or obstruction due to MI/R injury . Positive_regulation FLI1 CTGF 21760921 2456298 Recombinant *activated* Src and Erk1/2 signaling , and induced phosphorylation of [Fli1] , but was unable to stimulate Smad1 or Smad3 phosphorylation . Positive_regulation FLNA CAPN8 19177143 2086370 Wnt5A activates the *mediated* cleavage of [filamin A] . Positive_regulation FLNA CAPN8 24550283 2915428 Hypoxia induces a *dependent* cleavage of [FLNA] to generate a naturally occurring C-terminal fragment that accumulates in the cell nucleus . Positive_regulation FLNA SPHK1 18644866 1954716 was *required* for heregulin induced migration , lamellipodia formation , activation of PAK1 , and subsequent [FLNa] phosphorylation . Positive_regulation FLOT1 TNF 22732732 2676136 [FLOT1] *activates* receptor signaling and sustains activation of NF-?B in ESCC cells . Positive_regulation FLT1 ANGPT1 16107612 1448409 These phenotypes depend strongly on p110gamma rather than on p85alpha and were associated with decreased expression of , VCAM-1 , connexin 40 , and ephrinB2 but *increased* expression of Ang-2 , VEGF-A , [VEGFR1] , and VEGFR2 . Positive_regulation FLT1 FOXO1 16116481 1482168 The alveolar subtype of RMS is often characterized by the presence of a translocation , and when introduced into non-RMS cells , the resultant fusion protein *induces* expression of [VEGFR1] . Positive_regulation FLT1 IL1B 17071533 1637655 *regulates* vascular endothelial growth factor and soluble [fms-like tyrosine kinase-1] secretion by human oviductal epithelial cells and stromal fibroblasts . Positive_regulation FLT1 IL1B 19180491 2033119 The response to PlGF was associated with increased expression of [flt-1] on RA monocytes , which could be *induced* by and TNFalpha . Positive_regulation FLT1 MAP2K6 18056475 1833693 inhibition also *resulted* in a rapid decline in the [ ( 18 ) F ] [FLT] signal in V600E BRAF mutant SKMEL-28 xenografts but not in BRAF wild-type BT-474 xenografts . Positive_regulation FLT1 PECAM1 24625025 2925471 Bevacizumab treatment *induced* significant low expression of mouse Pecam1/Cd31 , Eng/Cd105 , [Flt1/Vegfr1] and Kdr/Vefr2 while the human and VEGFA were upregulated . Positive_regulation FLT1 TNF 19180491 2033118 The response to PlGF was associated with increased expression of [flt-1] on RA monocytes , which could be *induced* by IL-1beta and . Positive_regulation FLT3 MAP2K6 24116827 2937976 These findings explain the phenomenon of peripheral blood versus bone marrow blast responses and suggest that the combination of potent [FLT3] inhibition and *inhibition* is a promising strategy for the treatment of FLT3-ITD AML . Positive_regulation FLT3LG TLR7 23090076 2690533 Combined stimulation with Pam3Cys and Poly I: C *enhances* [Flt3-ligand] dendritic cell activation for tumor immunotherapy . Positive_regulation FLT3LG TLR7 23685841 2796662 Plasmodium induced [Flt3l] release in mice *requires* activation and type I interferon ( IFN ) production . Positive_regulation FMOD IL1B 22073367 2504485 Expression of lumican and [fibromodulin] *following* stimulation of disc cells of the human temporomandibular joint . Positive_regulation FN1 AGR2 25092909 2956950 Therefore , while *regulates* [fibronectin] binding in SCVs , it can not promote hemolysin production in the absence of a functional electron transport chain . Positive_regulation FN1 CTGF 10942593 722627 *stimulated* a two- to threefold increase in proalpha1 ( I ) collagen and [fibronectin] synthesis by both dermal and lung fibroblasts in culture and promoted significant matrix remodeling of fibroblast populated three-dimensional collagen lattices . Positive_regulation FN1 CTGF 11012874 736219 Recombinant human *augments* the production of [fibronectin] and type IV collagen by mesangial cells and the effects of high glucose on mesangial cell CTGF expression and matrix production are attenuated , in part , by anti-TGF-beta antibody . Positive_regulation FN1 CTGF 11934704 927854 *Role* of in [fibronectin] expression and tubulointerstitial fibrosis . Positive_regulation FN1 CTGF 15536170 1374830 ( 20 ng/ml ) *induced* [fibronectin] and collagen IV secretion in primary cultures of human proximal tubule cells (PTC) and cortical fibroblasts ( CF ) compared with control values ( P < 0.005 in all cases ) . Positive_regulation FN1 CTGF 15536170 1374852 TGF-beta(1) *induced* a greater increase in [fibronectin] and collagen IV secretion in both PTC ( P < 0.01 ) and CF ( P < 0.01 ) compared with that observed with alone . Positive_regulation FN1 CTGF 16179645 1500682 In both asthmatic and nonasthmatic airway smooth muscle cells , TGF-beta and *led* to the production of [fibronectin] and collagen I . Positive_regulation FN1 CTGF 16204411 1517643 Our studies further demonstrate that in the CTGF gene silenced cells , partially *mediates* TGF-beta(1) induced [fibronectin] and collagen IV secretion . Positive_regulation FN1 CTGF 16522717 1531334 As assessed by RT-PCR or Western blotting , ( 3 ) *stimulated* production of [fibronectin] and pro-collagen type IV(alpha5) , both of which are downstream components of HSC mediated fibrogenesis and which are constituents of high density matrix in fibrotic lesions . Positive_regulation FN1 CTGF 16527597 1536196 *Role* of in [fibronectin] synthesis in cultured human prostate stromal cells . Positive_regulation FN1 CTGF 16528248 1536310 significantly *induced* cell hypertrophy , increased [fibronectin] , and collagen IV secretion in PTCs and CFs . Positive_regulation FN1 CTGF 17303801 1733692 also *stimulated* the synthesis of [fibronectin] by hyalocytes and BRPEs without significant effect on collagen gel contraction by these cells . Positive_regulation FN1 CTGF 17399955 1748564 The up-regulation of angiotensin II receptor type 1 and are *involved* in high-glucose induced [fibronectin] production by cultured human dermal fibroblasts . Positive_regulation FN1 CTGF 18471259 1910363 also *increased* the secretion of [fibronectin] and collagen I protein in the supernatant medium . Positive_regulation FN1 CTGF 18471259 1910368 Inhibition of ERK1/2 activation with PD98059 completely blocked *induced* cell proliferation as well as secretion of [fibronectin] and collagen I protein . Positive_regulation FN1 CTGF 19276073 2072861 *increased* [fibronectin (FN)] amount , MMP-2 mRNA expression , and gelatinase activity in 3T3 cells . Positive_regulation FN1 CTGF 21630131 2459321 Using CCN-2 adenoviral anti-sense it was found that *mediated* the up-regulation of [fibronectin] and the tissue inhibitor of matrix metalloproteinase , TIMP-1 , that was caused by matrix bound AGEs . Positive_regulation FN1 CTGF 22542845 2602931 *induces* TM [fibronectin] and a-SMA in animals , whereas actin stress fibers and contractility are both induced in cultured TM cells . Positive_regulation FN1 CTGF 23550216 2767182 Preincubation of ARPE-19 with Y27632 ( 10mmol/L ) significantly prevented or TGF- ß *induced* [fibronectin] ( P=0.005 , P=0.003 respectively ) , MMP-2 ( P= 0.003 , P=0.002 ) , COL1A1 ( P=0.006 , P=0.003 ) , and COL1A2 ( P=0.006 , P=0.004 ) gene expression , but not laminin ( P=0.375 , P=0.516 ) . Positive_regulation FN1 CTGF 24052232 2857439 can *enhance* the expression of [fibronectin] , collagen IV and CTGF . Positive_regulation FN1 CTGF 8751978 377242 *Stimulation* of type I collagen and [fibronectin] protein synthesis by TGF-beta and was confirmed by pulse labeling of cells with [ 35S ] methionine . Positive_regulation FN1 EDN2 12388107 1034981 High glucose induced , *dependent* [fibronectin] synthesis is mediated via NF-kappa B and AP-1 . Positive_regulation FN1 EDN2 8757219 377692 The release of [fibronectin] and tumor necrosis factor-alpha *induced* by was studied in alveolar macrophages by enzyme immunoassay . Positive_regulation FN1 EDN2 8757219 377698 significantly *increased* the release of tumor necrosis factor-alpha and [fibronectin] by alveolar macrophages from normal subjects and patients with stable asthma , but it significantly decreased their release in patients with unstable asthma . Positive_regulation FN1 EPHB2 11986211 935817 [Fibronectin-] and protein kinase C-mediated *activation* of are essential for proplateletlike formation . Positive_regulation FN1 EPHB2 15919517 1413369 Cell proliferation was assessed by methylthiazoletetrazolium ( MTT ) assay , [fibronectin] secretion , and the *activation* of Akt , , and p38 MAPK by Western blot analysis . Positive_regulation FN1 EPHB2 15919517 1413386 PDGF increased cell proliferation , [fibronectin] secretion , and the *activation* of Akt , , and p38 MAPK in both VSMCs and MCs . Positive_regulation FN1 EPHB2 15919517 1413403 However , [fibronectin] secretion and the *activation* of Akt , , and p38 MAPK were not affected by this nontoxic concentration of TMC . Positive_regulation FN1 EPHB2 16572112 1556001 Ras modulation of superoxide activates *dependent* [fibronectin] expression in diabetes induced renal injuries . Positive_regulation FN1 EPHB2 20483351 2288608 CS *inhibited* S100b induced TGF-beta1 and [fibronectin] expression in mouse mesangial cells by suppressing activation of Smad2/3 , extracellular signal regulated kinase ( ) /mitogen activated protein kinase (MAPK) , and oxidative stress . Positive_regulation FN1 EPHB2 21337395 2394315 [Fibronectin] fragment *activation* of increasing integrin a5 and ß1 subunit expression to degenerate nucleus pulposus cells . Positive_regulation FN1 F2R 17492768 1772361 Activation of *induced* dynamic cytoskeletal reorganization and reduced PC-3 binding to collagen I , collagen IV , and laminin ( P < 0.01 ) but not [fibronectin] . Positive_regulation FN1 GPR115 19342448 2094278 Coordinate regulation of estrogen mediated [fibronectin] matrix assembly and epidermal growth factor receptor *transactivation* by the , GPR30 . Positive_regulation FN1 GPR132 19342448 2094267 Coordinate regulation of estrogen mediated [fibronectin] matrix assembly and epidermal growth factor receptor *transactivation* by the , GPR30 . Positive_regulation FN1 GPR87 19342448 2094348 Coordinate regulation of estrogen mediated [fibronectin] matrix assembly and epidermal growth factor receptor *transactivation* by the , GPR30 . Positive_regulation FN1 HBEGF 10210777 607672 Thus physiologically , transient destruction of LN and expression of VCAM-1 , E-selectin and [fibronectin] at sites of inflammation , may locally *induce* overexpression . Positive_regulation FN1 IL1B 10433157 633927 However , *induced* [fibronectin] mRNA expression was only partially blocked by neutralizing anti-TGFbeta antibody . Positive_regulation FN1 IL1B 12081561 958396 *induces* human proximal tubule cell injury , alpha-smooth muscle actin expression and [fibronectin] production . Positive_regulation FN1 IL1B 12081561 958398 significantly *enhanced* [fibronectin] secretion by up to fourfold in a time- and concentration dependent fashion . Positive_regulation FN1 IL1B 12081561 958399 NG-methyl-l-arginine ( L-NMMA ; 1 mmol/L ) , a specific inhibitor of NOS , blocked NO production but did not alter basal or *stimulated* [fibronectin] secretion . Positive_regulation FN1 IL1B 12434136 1015815 However , addition of a TGF-beta neutralizing antibody significantly reduced *induced* [fibronectin] secretion ( IL-1beta + IgG , 262 % +/- 72 % vs IL-1beta + alphaTGF-beta 156 % +/- 14 % , P < .02 ) , collagen type 1 production ( IL-1beta + IgG , 176 % +/- 28 % vs IL-1beta + alphaTGF-beta , 120 % +/- 14 % , P < .005 ) and abrogated IL-1beta induced DNA synthesis ( 245 % +/- 49 % vs 105 % +/- 21 % , P < .005 ) . Positive_regulation FN1 IL1B 12434136 1015816 significantly *stimulated* CF DNA synthesis and production of [fibronectin] , collagen type 1 , TGFbeta , and NO . Positive_regulation FN1 IL1B 15705185 1372747 The anti-oxidant ( 4 mmol/L ) partially blocked *induced* [fibronectin] secretion by PTC , but did not affect IL-1beta induced LDH release , RNS release or growth inhibition . Positive_regulation FN1 IL1B 7650068 319313 We now investigate , using a porcine endothelial-smooth muscle cell co-culture system , whether *stimulated* [fibronectin] production is functionally important in lymphocyte transendothelial migration . Positive_regulation FN1 IL1B 7896895 299948 Reciprocal induction of tumor necrosis factor-alpha and activity *mediates* [fibronectin] synthesis in coronary artery smooth muscle cells . Positive_regulation FN1 IL1B 7896895 299950 Likewise , *stimulated* [fibronectin] synthesis was downregulated to control levels when TNF-alpha neutralizing antibodies were added . Positive_regulation FN1 IL1B 7896895 299952 Combining TNF-alpha and *enhanced* [fibronectin] production over that observed with either cytokine alone , but was not additive . Positive_regulation FN1 IL1B 7896895 299965 Thus , our studies suggest that vascular SMC [fibronectin] synthesis is *regulated* by reciprocal induction of and TNF-alpha activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Positive_regulation FN1 IL1B 8222162 232291 Coronary artery endothelial *mediates* enhanced [fibronectin] production related to post-cardiac transplant arteriopathy in piglets . Positive_regulation FN1 IL1B 8267042 239330 Production of fetal [fibronectin] was *increased* by lipopolysaccharide , , and tumor necrosis factor-alpha . Positive_regulation FN1 IL1B 8315884 222876 also transcriptionally *increased* the mRNA levels for alpha 1 ( I ) alpha 1 ( IV ) collagens and [fibronectin] in the non stimulated MCs , however , inhibited the increase of these mRNA levels in the TGF-beta treated MCs . Positive_regulation FN1 IL1B 8408637 233321 *Upregulation* of [fibronectin] synthesis by in coronary artery smooth muscle cells is associated with the development of the post-cardiac transplant arteriopathy in piglets . Positive_regulation FN1 IL1B 8408637 233322 We therefore suggest in the coronary arteriopathy a pathophysiologic mechanism whereby mediated *increased* [fibronectin] synthesis may promote lymphocyte trapping and migration of medial smooth muscle cells leading to progressive intimal thickening associated with the post-cardiac transplant coronary arteriopathy . Positive_regulation FN1 IL1B 9423716 472540 *caused* an increase in the production of [fibronectin] , a decrease in the production of laminin , and no change in the production of collagen type IV . Positive_regulation FN1 MAMLD1 11358957 834495 Conversely , binding of to TSP1 *enhanced* TSP1 binding to [fibronectin] . Positive_regulation FN1 MAP2K6 16157583 1475827 Pharmacologic inhibitors of protein kinase C , Ras , and , but not phosphoinositide 3-kinase , *block* ST6Gal-I down-regulation , integrin hyposialylation , and [fibronectin] binding . Positive_regulation FN1 PLAU 16882037 1594550 Mono Mac 6 ( MM6 ) cells as well as peripheral blood monocytes enhanced transmigration of B. burgdorferi across a barrier coated with [fibronectin] *mediated* by . Positive_regulation FN1 PLAU 8883963 390990 In vitro , noncytotoxic concentrations of B428 or B623 inhibited secreted and cell associated uPA activity produced by tumor cells and blocked *mediated* whole tumor cell degradation of [fibronectin] , allowing deposition of extracellular fibronectin fibrils . Positive_regulation FN1 S100B 19666101 2132705 KIOM-79 prevents *induced* TGF-beta1 and [fibronectin] expression in mouse mesangial cells . Positive_regulation FN1 S100B 19666101 2132707 The effect of KIOM-79 on *induced* TGF-beta1 and [fibronectin] expression was investigated using RT-PCR , ELISA , and Western blot on mesangial cells . Positive_regulation FN1 S100B 20483351 2288602 Extract of Cassiae Semen and its major compound inhibit *induced* TGF-beta1 and [fibronectin] expression in mouse glomerular mesangial cells . Positive_regulation FN1 S100B 20483351 2288607 CS inhibited *induced* TGF-beta1 and [fibronectin] expression in mouse mesangial cells by suppressing activation of Smad2/3 , extracellular signal regulated kinase ( ERK ) /mitogen activated protein kinase (MAPK) , and oxidative stress . Positive_regulation FN1 S1PR3 22406263 2577324 In the current study , we explored *role* of in [fibronectin] expression and underlying molecular mechanism . Positive_regulation FN1 TGM2 11686302 875837 Surface *increases* the binding of [fibronectin] to cells via interaction with its gelatin binding domain that contains modules I6II1,2I7-9 and lacks integrin binding motifs . Positive_regulation FN1 TGM2 24246248 2892414 activity arising from Factor XIIIA is *required* for stabilization and conversion of plasma [fibronectin] into matrix in osteoblast cultures . Positive_regulation FN1 TNF 10893215 711346 Transglutaminase mediated [fibronectin] multimerization in lung endothelial matrix in *response* to . Positive_regulation FN1 TNF 11440974 833343 *induces* [fibronectin] synthesis in coronary artery smooth muscle cells by a nitric oxide dependent posttranscriptional mechanism . Positive_regulation FN1 TNF 11440974 833344 Because expression of inducible nitric oxide synthase (iNOS) is elevated in neointimal formation after transplantation and upregulated in vascular SMCs by TNF-alpha , we investigated whether *induction* of [fibronectin] synthesis in coronary artery ( CA ) SMCs is mediated by nitric oxide ( NO ) . Positive_regulation FN1 TNF 11440974 833345 *induction* of [fibronectin] synthesis was abrogated by the NOS inhibitor N ( G ) -monomethyl-L-arginine ( L-NMMA ) ( P < 0.05 ) or the flavonoid containing enzyme inhibitor diphenyleneiodonium ( DPI ) ( P < 0.05 ) and reproduced with the NO donor S-nitroso-N-acetyl-penicillamine (SNAP) ( P < 0.05 ) . Positive_regulation FN1 TNF 12628313 1067010 The increases in [fibronectin] levels were 164 , 552 , 490 , 769 , 335 , 257 and 61 % at the corresponding times , but neither nor interleukin-1 *increased* . Positive_regulation FN1 TNF 16322943 1487979 Further , *potentiated* adenosine induced shortcircuit current and [fibronectin] secretion . Positive_regulation FN1 TNF 16632126 1552552 Notoginsenoside R1 inhibits *induced* [fibronectin] production in smooth muscle cells via the ROS/ERK pathway . Positive_regulation FN1 TNF 16632126 1552554 These results suggest that notoginsenoside R1 inhibits *induced* ERK activation and subsequent [fibronectin] overexpression and migration in HASMCs by suppressing NADPH oxidase mediated ROS generation and directly scavenging ROS . Positive_regulation FN1 TNF 18001729 1903201 The ability of various proteins to inhibit *induced* [fibronectin-bead] binding was measured . Positive_regulation FN1 TNF 18053242 1836234 LPS and *induced* collagen1 and [fibronectin] levels as well as the matrix degradation enzyme MMP-1 . Positive_regulation FN1 TNF 18929503 2053187 Our observations indicate that TGF-beta and *stimulates* [fibronectin] expression only in uninfected cells of the T. cruzi infected cultures , whereas the cells harboring the parasites display low or no fibronectin fibrils . Positive_regulation FN1 TNF 19541932 2099106 Inhibition of by soluble TNFR2 , etanercept , *reduced* significantly , although transiently , tubular and interstitial cell proliferation , [fibronectin] expression , and apoptosis in UUO kidneys , and also suppressed TRADD degradation . Positive_regulation FN1 TNF 7896895 299947 Reciprocal induction of and interleukin-1 beta activity *mediates* [fibronectin] synthesis in coronary artery smooth muscle cells . Positive_regulation FN1 TNF 7896895 299949 In normal CA SMC , *stimulated* [fibronectin] production was downregulated to or below control levels in the presence of IL-1 beta antibodies . Positive_regulation FN1 TNF 7896895 299951 Combining and IL-1 beta *enhanced* [fibronectin] production over that observed with either cytokine alone , but was not additive . Positive_regulation FN1 TNF 7896895 299964 Thus , our studies suggest that vascular SMC [fibronectin] synthesis is *regulated* by reciprocal induction of IL-1 beta and activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Positive_regulation FN1 TNF 7945918 276583 Interferon-gamma and *promote* the binding of dendritic cells to [fibronectin] . Positive_regulation FN1 TNF 8094922 211861 and transforming growth factor beta 1 ( TGF beta 1 ) *stimulate* [fibronectin] synthesis and the transdifferentiation of fat storing cells in the rat liver into myofibroblasts . Positive_regulation FN1 TNF 8267042 239329 Production of fetal [fibronectin] was *increased* by lipopolysaccharide , interleukin-1 beta , and . Positive_regulation FN1 TNF 8796813 381289 Unstimulated amnion cells produced fetal [fibronectin] , and production was *increased* by lipopolysaccharide , interleukin-1 beta , , and interleukin-6 . Positive_regulation FN1 TNF 9749946 533253 The regulation of TN-C expression in keratinocytes is distinct from that of fibronectin , since IL-4 and IFNgamma did not affect fibronectin expression in our experiments , and only slightly *increased* [fibronectin] levels . Positive_regulation FNDC5 PGC 24120943 2863712 Neuronal [Fndc5] gene expression is *regulated* by , and Pgc1a ( -/- ) mice show reduced Fndc5 expression in the brain . Positive_regulation FNTA MAP2K6 23546290 2763035 Second , [farnesyltransferase] *inhibitor* I , a Ras inhibitor , and U0126 , a inhibitor , induced an inhibition of the cell proliferation in C6 cells , while the cell proliferation was inhibited by nobiletin as well . Positive_regulation FNTB MAP2K6 23546290 2763042 Second , [farnesyltransferase] *inhibitor* I , a Ras inhibitor , and U0126 , a inhibitor , induced an inhibition of the cell proliferation in C6 cells , while the cell proliferation was inhibited by nobiletin as well . Positive_regulation FOLR1 CBX1 8104505 229116 In the MSA treated KK mice , GK activity did not change and activity decreased , and only [FBP] activity *increased* significantly . Positive_regulation FOLR1 CBX2 8104505 229117 In the MSA treated KK mice , GK activity did not change and activity decreased , and only [FBP] activity *increased* significantly . Positive_regulation FOLR1 CBX3 8104505 229118 In the MSA treated KK mice , GK activity did not change and activity decreased , and only [FBP] activity *increased* significantly . Positive_regulation FOLR1 CBX4 8104505 229119 In the MSA treated KK mice , GK activity did not change and activity decreased , and only [FBP] activity *increased* significantly . Positive_regulation FOLR1 CBX5 8104505 229120 In the MSA treated KK mice , GK activity did not change and activity decreased , and only [FBP] activity *increased* significantly . Positive_regulation FOLR1 CBX6 8104505 229121 In the MSA treated KK mice , GK activity did not change and activity decreased , and only [FBP] activity *increased* significantly . Positive_regulation FOLR1 CBX7 8104505 229122 In the MSA treated KK mice , GK activity did not change and activity decreased , and only [FBP] activity *increased* significantly . Positive_regulation FOLR1 CBX8 8104505 229123 In the MSA treated KK mice , GK activity did not change and activity decreased , and only [FBP] activity *increased* significantly . Positive_regulation FOLR1 FOLR2 16441932 1516862 Added significantly *reduced* folate absorption from dairy products , as in the absence of [FBP] , AUC-dose corrected ratios were increased and ileal folate excretion decreased . Positive_regulation FOLR1 FOLR2 20436070 2268253 The correlated negatively with the extent of nailfold microvascular damage , and IV iloprost treatment *increased* the [FBP] . Positive_regulation FOS ANGPT1 9258997 448585 [Fos-IR] *induced* in brain by was not markedly affected by either acute or chronic treatment with captopril . Positive_regulation FOS ANGPT1 9889323 585397 Pretreatment of the SFO with either captopril , an ANG converting enzyme inhibitor , or losartan , an AT1 receptor antagonist , abolished both drinking and [Fos-ir] *induced* by . Positive_regulation FOS CCND1 21847632 2524271 We found that , in lung cancer cell lines and in nude mice , Interleukin-7/Interleukin-7 receptor increased the expression of and phosphorylation of c-Fos/c-Jun , *induce* [c-Fos] and c-Jun heterodimer formation , and enhanced c-Fos/c-Jun DNA binding activity to regulate cyclin D1 . Positive_regulation FOS CCND1 9710644 526963 Although definitive evidence that [c-Fos] and FosB directly *induce* transcription will require further analysis , these findings raise the possibility that c-Fos and FosB are either direct or indirect transcriptional regulators of the cyclin D1 gene and may function as a critical link between serum stimulation and cell cycle progression . Positive_regulation FOS EPHB2 10454742 638361 ACTH , itself a very weak mitogen , blocks the mitogenic response effect of FGF2 in the early and middle G1 phase , keeping both activation and [c-Fos] *induction* at maximal levels . Positive_regulation FOS EPHB2 10873670 708598 Exposure of mesangial cells to ionic Cd ( 2+ ) *induces* the [proto-oncogene c-fos] , while activating both and stress activated protein kinase ( SAPK ) MAP kinase pathways . Positive_regulation FOS EPHB2 11004713 734993 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping activation and [c-Fos] and cyclin D1 *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation FOS EPHB2 11196459 762016 In G0/G1 cell cycle arrested mouse Y1 adrenocortical tumor cells ACTH39 , a weak mitogen and strong anti-mitogenic agent , blocks FGF2 mitogenic activity at G1 phase , keeping untouched activation and [c-Fos] protein *induction* . Positive_regulation FOS EPHB2 11359772 834564 Serum stimulated [c-Fos] expression is *dependent* on activity because the MEK inhibitor PD98059 suppresses Erk activity and c-Fos expression . Positive_regulation FOS EPHB2 12411479 1010826 The Raf-1/B-Raf double deficient DT40 cells show an almost complete block both in activation and in the *induction* of the immediate early gene products [c-Fos] and Egr-1 . Positive_regulation FOS EPHB2 12972619 1139614 Furthermore , we provide evidence that the dependent *activation* of [c-Fos] is an integral component of the mitogenic pathway by which PDGF regulates normal and aberrant cell growth . Positive_regulation FOS EPHB2 15005710 1217459 Cytoplasmic [c-Fos] induced by the YXXQ derived STAT3 signal *requires* the co-operative signal for its nuclear translocation . Positive_regulation FOS EPHB2 15063796 1230994 TPA stimulated *dependent* increases in [c-Fos] protein and the c-Fos content of AP-1 complexes . Positive_regulation FOS EPHB2 15193999 1259707 The effect of FK960 on [c-Fos] was *inhibited* by PD98059 ( 10microM ) , an kinase inhibitor , and cycloheximide ( 1microg/ml ) , a transcription inhibitor , and the effect of FK960 on CREB phosphorylation was blocked by PD98059 . Positive_regulation FOS EPHB2 15615716 1375492 Additional experiments reveal that , in conjunction with p65 NF-kappaB , the *dependent* synthesis of [c-Fos] and Fra-1 serves to adjust the overall expression level of IL-8 in response to two of its physiological inducers , IL-1 and epidermal growth factor . Positive_regulation FOS EPHB2 15930517 1433901 Moreover , inhibition of and JNK by EPA *resulted* in the decrease of [c-Fos] expression and c-Jun phosphorylation/expression induced by UV , respectively , which led to the inhibition of UV-induced activator protein-1 DNA binding activity . Positive_regulation FOS EPHB2 15993334 1429655 Whereas inhibiting the ERK pathway with the MEK inhibitor PD98059 significantly decreased HNE mediated phosphorylation , [c-Fos] protein *induction* , AP-1 binding , and HO-1 protein induction , inhibition of the ERK pathway had no effect on HNE induced HO-1 mRNA . Positive_regulation FOS EPHB2 16051824 1438638 Several MAPK regulated host transcription factors such as c-Jun , STAT1alpha , MEF2 , c-Myc , ATF-2 and c-Fos were induced early during infection , and inhibition significantly *blocked* the [c-Fos] , c-Jun , c-Myc , and STAT1alpha activation in the infected cells . Positive_regulation FOS EPHB2 16289800 1490648 The spinal inhibition or knockdown also *reduced* morphine withdrawal induced phosphorylation of cAMP response element binding protein ( CREB ) , which is one of the important downstream substrates of ERK pathway , and [Fos] expression . Positive_regulation FOS EPHB2 16413539 1514348 Moreover , inhibitions of and JNK by 2',4',7-THF *resulted* in the decrease of [c-Fos] expression and c-Jun phosphorylation/expression induced by UV , respectively , which led to the inhibition of UV-induced AP-1 DNA binding activity . Positive_regulation FOS EPHB2 17052890 1700321 In CCl39 fibroblasts , sustained ERK1/2 activation is required for the expression of Fra-1 , Fra-2 , c-Jun and JunB , whereas expression of [c-Fos] is still strongly induced even in *response* to transient activation . Positive_regulation FOS EPHB2 17543352 1773308 In the dorsal horn of naïve but not CFA rats , DHPG increased [Fos] expression and this was *reduced* by MPEP and both PKC and inhibitors . Positive_regulation FOS EPHB2 17920048 1813047 A single cocaine administration ( 30 mg/kg ) increased *mediated* signaling proteins , phosphoryation of cAMP response element binding protein ( CREB ) kinase , pp90 ribosomal S6 kinase ( RSK ) , and [c-Fos] protein levels in the caudate/putamen of Fischer rats . Positive_regulation FOS EPHB2 18348889 1971625 Inhibition of phosphorylation *blocked* the anxiety induced [c-Fos] expression . Positive_regulation FOS EPHB2 18433733 1908047 In conclusion , bavachalcone inhibits osteoclastogenesis by interfering with the and Akt signaling pathways and the *induction* of [c-Fos] and NFATc1 during differentiation . Positive_regulation FOS EPHB2 18479823 1916748 Furthermore , using an immunofluorescent staining approach , we found that inhibition of ERK activation completely abolished cocaine induced increase in number of c-Fos positive cells in the core region of NAc , whereas , in shell region of NAc , inhibition of activation partially *attenuated* cocaine induced [c-Fos] expression . Positive_regulation FOS EPHB2 19587381 2129547 Inhibition of *prevented* induction of [c-Fos] by M-CSF and reduced C/EBPalpha phosphorylation and formation of colony forming unit-monocytes . Positive_regulation FOS EPHB2 19587381 2129555 In summary , M-CSF activates more potently than G-CSF , and thereby *induces* higher levels of [c-Fos] and phospho-C/EBPalpha ( S21 ) , which may directly interact to favor monopoiesis , whereas G-CSF activates signal transducer and activator of transcription 3 and SHP2 , potentially shifting the balance to granulopoiesis via gene induction by C/EBPalpha homodimers and via effects of SHP2 on regulators besides ERK . Positive_regulation FOS EPHB2 19627209 2112769 Moreover , inhibition of phosphorylated , JNK , and p38 by K. pandurata extract *resulted* in decreased [c-Fos] expression and c-Jun phosphorylation induced by UV light . Positive_regulation FOS EPHB2 19935718 2210116 In addition , OHT induced *dependent* expression of [c-Fos] and transactivation of an AP-1-responsive promoter . Positive_regulation FOS EPHB2 20331627 2299865 Moreover , [c-Fos] and c-Jun , the major downstream components of MAPKs , were *up-regulated* by and JNK , respectively . Positive_regulation FOS EPHB2 22865631 2666107 Gallic acid treatment repressed *mediated* [c-Fos] phosphorylation and JNK1 mediated ATF-2 phosphorylation . Positive_regulation FOS EPHB2 23018815 2698175 is *involved* in tooth-pressure induced [Fos] expression in Vc neurons . Positive_regulation FOS GLP1R 9729361 530137 These results suggest that LiCl induced [c-Fos] expression in the rat brainstem is *mediated* , at least in part , by signaling . Positive_regulation FOS IL1B 11058221 746190 Combined hybridization histochemical detection of EP3R mRNA with immunolocalization of *induced* [Fos] protein expression identified cytokine-sensitive , EP3R positive cells in the medial NTS , rostral VLM , and , to a lesser extent , aspects of the MPO . Positive_regulation FOS IL1B 12064845 953430 Of note , in OA chondrocytes , IL-17 and IL-1beta induced collagenase-3 production through AP-1 occurred with differential protein complexes : IL-17 stimulation resulted in FosB activation , while *stimulated* [c-Fos] . Positive_regulation FOS IL1B 12713650 1083450 To identify brain regions that might mediate the effect of medial prefrontal cortex lesions on hypothalamic-pituitary-adrenal axis responses to systemic interleukin-1beta , we next mapped the effects of similar lesions on *induced* [Fos] expression in regions previously shown to regulate the hypothalamic-pituitary-adrenal axis response to this stressor . Positive_regulation FOS IL1B 12801886 1149497 significantly *increased* [c-Fos] expression in submucosal neurons compared with the control ( 34.2 +/- 10.1 vs. 5.1 +/- 1.3 % of NSE neurons ) . Positive_regulation FOS IL1B 12881225 1157241 *induced* [Fos] expression in enteric neurons and also in enteric glia in the ileum and colon . Positive_regulation FOS IL1B 14595770 1160286 Unilateral ibotenic acid lesions encompassing the ventral BNST significantly reduced both *induced* increases in [Fos] immunoreactivity in corticotropin releasing factor (CRF) cells of the hypothalamic paraventricular nucleus ( PVN ) and corresponding increases in adrenocorticotropic hormone ( ACTH ) secretion . Positive_regulation FOS IL1B 14595770 1160287 In further studies , we examined the functional connections between PVN , BNST , and CeA by combining retrograde tracing with mapping of *induced* increases in [Fos] in BNST and CeA cells . Positive_regulation FOS IL1B 15223234 1264758 These results suggest that the parabrachial nucleus plays a critical role in *induced* [Fos] expression in CeA , BNST and VLM neurons and that neurons of the NTS and VLM may serve to trigger or at least influence changes in parabrachial nucleus activity that follows systemic interleukin-1beta administration . Positive_regulation FOS IL1B 15900319 1451774 Inactivation of the cerebral NFkappaB pathway inhibits *induced* sickness behavior and [c-Fos] expression in various brain nuclei . Positive_regulation FOS IL1B 15900319 1451780 NFkappaB pathway inactivation significantly blocked the behavioral effects of intraperitoneally administered IL-1beta in the form of social withdrawal and decreased food intake , and dramatically reduced *induced* [c-Fos] expression in various brain regions as paraventricular nucleus , supraoptic nucleus , and lateral part of the central amygdala . Positive_regulation FOS IL1B 15993445 1441273 *induced* [Fos-immunoreactivity (Fos-IR)] in medial parvocellular paraventricular nucleus ( mPVN ) corticotropin releasing hormone (CRH) neurons but increased responses in the ventrolateral medulla ( VLM ) C1 ( 65 % ) and nucleus tractus solitarius (NTS) A2 ( 110 % ) catecholamine cell groups and area postrema ( 136 % ) . Positive_regulation FOS IL1B 16015027 1441476 alpha-Melanophore stimulating hormone ( alpha-MSH ) antagonizes *induced* hyperalgesia and [Fos] expression in the paraventricular and arcuate nucleus of the rat . Positive_regulation FOS IL1B 17496810 1739503 This study investigated the *role* of in the expression of [Fos] , a marker of neuronal activation , and hyperalgesia caused by injecting complete Freund 's adjuvant into one hind paw of the rat . Positive_regulation FOS IL1B 7668153 322224 In this study , we compared the effects of morphine , ethanol and cocaine on *induction* of [FOS-IR] in the rat hypothalamus . Positive_regulation FOS IL1B 7668153 322225 Chronic treatment with morphine desensitized FOS responsiveness to morphine and IL-1 beta in the PVN since [FOS-IR] was no longer *induced* by or morphine in the PVN after this treatment . Positive_regulation FOS IL1B 8025563 263305 Both stress and *induced* robust [Fos-ir] expression within the parvocellular division of the PVN in all 3 strains . Positive_regulation FOS IL1B 8761989 379078 In order to determine whether *induced* [Fos] protein expression in the paraventricular hypothalamic nucleus ( PVN ) can be reduced or eliminated by a c-fos antisense oligodeoxynucleotide , rats were injected with c-fos antisense and Fos expression was examined immunocytochemically . Positive_regulation FOS IL1B 8883917 390979 Intraperitoneally injected *increased* [Fos] in several brain regions , but most obviously in the hypothalamic paraventricular nucleus ( PVN ) . Positive_regulation FOS IL1B 9058778 417689 *induced* [Fos] expression in corticotrophin releasing factor (CRF) neurons of paraventricular nucleus ( PVN ) of the hypothalamus , and anterior pituitary gland . Positive_regulation FOS JAG1 9780150 540486 Since [c-Fos] is *induced* in mature B cells reacted with , and clonal deletion of self-reactive B cells in germinal centers is insensitive to Bcl-2 , these results suggest that c-Fos plays a causal role in clonal deletion of germinal center B cells . Positive_regulation FOS MAP2K6 11267996 797286 Extracellular signal regulated kinases ( ERK1 and ERK2 ) are also involved as the inhibitor , PD98059 , *reduced* both ATP evoked ( 3 ) H-thymidine incorporation and [c-Fos] and c-Jun expression . Positive_regulation FOS MAP2K6 15005710 1217465 Cytoplasmic [c-Fos] induced by the YXXQ derived STAT3 signal *requires* the co-operative signal for its nuclear translocation . Positive_regulation FOS MAP2K6 17026529 1641563 The effect of PACAP on [c-Fos] expression was *blocked* by the mitogen activated protein kinase/extracellular signal regulated kinase ( ) inhibitor , U0126 , while phosphorylation of c-Jun induced by C2-ceramide was abrogated by the protein phosphatase 2A (PP2A) inhibitor , okadaic acid . Positive_regulation FOS MAP2K6 9858557 582126 In cells expressing a conditionally active form of Raf-1 ( DeltaRaf-1 : ER ) , we observed that selective , sustained activation of was sufficient to induce expression of Fra-1 , Fra-2 , and JunB but , interestingly , *induced* little or no [c-Fos] or c-Jun . Positive_regulation FOS MMP7 22076613 2567999 Tissue factor/activated factor VIIa *induces* expression through activation of [c-Fos] via ERK1/2 and p38 MAPK signaling pathways in human colon cancer cell . Positive_regulation FOS SLC6A2 15763138 1383368 Dopamine and *dependent* [c-Fos] production in vitro : relevance to neuroadaptation . Positive_regulation FOS TNF 11641108 872052 *induced* [c-Fos] generation in the nucleus of the solitary tract is blocked by NBQX and MK-801 . Positive_regulation FOS TNF 11753501 890122 Among these we identified two oncogene products ( Jun and [Fos] ) which were *activated* by or phorbol esters and which promoted the synthesis of MMP-9 . Positive_regulation FOS TNF 12057991 952261 CREB-2 and [c-Fos] binding was *increased* by phorbol 12-myristate 13-acetate but not . Positive_regulation FOS TNF 14978197 1250880 Finally , the pretreatment of VSMCs with PTX or cilostamide , but not denbufylline , reduced *induced* CCL2/MCP-1 production , which was preceded by attenuation of p65/NF-kappaB nuclear translocation , p42/44 MAPK , and JNK-c-Jun phosphorylation , and [c-Fos] up-regulation . Positive_regulation FOS TNF 17424890 1723876 [c-Fos] and c-Jun mRNAs were *induced* by , and PD98059 ( MEK inhibitor ) and SB203580 ( p38 inhibitor ) abolished the up-regulation of c-Fos . Positive_regulation FOS TNF 17485464 1750566 RANKL- or *induced* [c-Fos] up-regulation and activation are abolished in dKO cells and in wild-type cells treated with an NF-kappaB inhibitor . Positive_regulation FOS TNF 18250170 1890709 induces IL-1 expression and *activates* [c-Fos] , a transcription factor required in OCPs for osteoclast formation . Positive_regulation FOS TNF 18250170 1890715 could *induce* [c-Fos] expression in OCPs at sites of inflammation in bone to promote this autocrine mechanism and thus amplify bone loss . Positive_regulation FOS TNF 18287248 1896539 Flavopiridol also inhibited the induced *induction* of intercellular adhesion molecule-1 , c-Myc , and [c-Fos] , all known to mediate tumorigenesis . Positive_regulation FOS TNF 20141610 2178970 *induced* increased levels of c-Jun and [C-Fos] in the nucleus accompanied by phosphorylation of c-Jun . Positive_regulation FOS TNF 20407282 2267571 IL-1beta , IL-6 and *stimulated* the nuclear expression levels of NF-kappaB , NF-kappaB dependent Nurr1 and [c-Fos] proteins . Positive_regulation FOS TNF 23553791 2804126 More interestingly , a long-term elevated levels of IFN-? and *result* in significantly increased susceptibility to malignant transformation in MSCs through NF?B mediated upregulation of the oncogenes [c-Fos] and c-Myc. Depletion of either IFN-? or TNF-a in OVX mice abolishes MSC impairment and the tendency toward malignant transformation with no NF?B mediated oncogene activation . Positive_regulation FOS TNF 24386331 2883763 Because of an inability to evoke sufficient ERK activation and Elk-1 phosphorylation , *induces* [c-Fos] more weakly than PMA does in both mouse and human cells . Positive_regulation FOS TNF 7935377 275810 Consistent with this possibility , IL-1 and markedly *increase* the binding of [Fos] and Jun to the AP-1 site , and NF-IL6 activates the native TSG-6 promoter . Positive_regulation FOS TNF 8997237 404525 We found that epidermal growth factor (EGF) and transiently *stimulate* an increase in [Fos] protein that precedes stimulation of the gastrin promoter . Positive_regulation FOS TNFSF10 11384965 849507 Upon overexpression of the long splice form of cellular FADD-like interleukin-1 converting enzyme ( FLICE ) inhibitory protein ( cFLIP ) in Jurkat cells , FasL- and *induced* up-regulation of [c-Fos] was almost completely blocked . Positive_regulation FOS TNFSF10 15757891 1417020 We also report a prolonged MEK dependent activation of ERK1/2 and increased [c-FOS] expression *induced* by in this system . Positive_regulation FOSB CCND1 9710644 526964 Although definitive evidence that c-Fos and [FosB] directly *induce* transcription will require further analysis , these findings raise the possibility that c-Fos and FosB are either direct or indirect transcriptional regulators of the cyclin D1 gene and may function as a critical link between serum stimulation and cell cycle progression . Positive_regulation FOSB NES 15861185 1425995 The adenovirus mediated expression of [FosB] or DeltaFosB *induced* expression of , glial fibrillary acidic protein and galectin-1 in rat embryonic cortical cells . Positive_regulation FOSL1 EPHB2 11756554 899155 These observations suggest that *dependent* activation of [Fra-1] is required for AP-1 transactivation in JB6 cells . Positive_regulation FOSL1 EPHB2 12414630 1011044 Mesothelial cell transformation requires increased AP-1 binding activity and *dependent* [Fra-1] expression . Positive_regulation FOSL1 EPHB2 12414630 1011045 In summary , we demonstrate that *dependent* [Fra-1] is elevated in AP-1 complexes in response to asbestos fibers and is critical to the transformation of mesothelial cells . Positive_regulation FOSL1 EPHB2 14625389 1170181 We show that c-JUN and [FRA-1] expression is *dependent* on activity and that different thresholds of ERK activity control the expression of FRA-1 . Positive_regulation FOSL1 EPHB2 15389548 1304762 Like NFLC , induction of urokinase plasminogen activator (uPAR) , transin/matrix metalloproteinase 3 (MMP3) , [Fra-1] and transforming growth factor beta 1 ( TGF beta 1 ) *required* collaborative and JNK signaling while the increased expression of cortexin , rat collapsin response mediator protein 4 ( rCRMP4 ) , rat growth and transformation dependent protein ( RGT ) , and synapsin II required neither mitogen activated protein kinase (MAPK) pathway . Positive_regulation FOSL1 EPHB2 15528491 1355045 Furthermore , treatment of cells with GM6001 , which inhibits matrix metalloproteinase activity , significantly suppressed CS-stimulated EGF shedding , EGFR and kinase phosphorylation , and subsequent [fra-1] *induction* . Positive_regulation FOSL1 EPHB2 15615716 1375490 Additional experiments reveal that , in conjunction with p65 NF-kappaB , the *dependent* synthesis of c-Fos and [Fra-1] serves to adjust the overall expression level of IL-8 in response to two of its physiological inducers , IL-1 and epidermal growth factor . Positive_regulation FOSL1 EPHB2 18249159 1871631 Furthermore , JNK but not ERK is required for ATF3 induction , and both and JNK are *necessary* for post-transcriptional induction of [Fra1] in response to cisplatin or UV . Positive_regulation FOSL1 EPHB2 19944019 2167691 Akt and p38 mitogen activated protein kinase ( p38 MAPK ) are necessary for CAGE mediated induction of the AP-1 subunit JunB , whereas is *necessary* for the induction of [fos related antigen-1 (Fra-1)] . Positive_regulation FOSL1 EPHB2 24164897 2889693 The decrease of active in the nucleus *inhibited* the activation of Elk1 , c-fos , and [Fra1] , the ERK nuclear targets , leading to decreased proliferation of HCC1806 cells . Positive_regulation FOSL1 HBEGF 12882762 1150072 Blocking ERK1/2 activation by MEK1/2 inhibitors ( PD-98059 or U-0126 ) diminishes *induced* [Fra-1] accumulation and subsequent downregulation of elastin mRNA . Positive_regulation FOSL1 MAP2K6 9858556 582045 Using these cells , we show that activation of *leads* to the expression of [Fra-1] and Fra-2 but not c-Fos . Positive_regulation FOSL1 MAP2K6 9858557 582103 In cells expressing a conditionally active form of Raf-1 ( DeltaRaf-1 : ER ) , we observed that selective , sustained activation of was *sufficient* to induce expression of [Fra-1] , Fra-2 , and JunB but , interestingly , induced little or no c-Fos or c-Jun . Positive_regulation FOSL1 TNF 17082637 1643351 A JNK independent signaling pathway regulates *stimulated* , c-Jun-driven [FRA-1] protooncogene transcription in pulmonary epithelial cells . Positive_regulation FOSL1 TNF 17082637 1643352 In this study , we report that *stimulates* the expression of the [FRA-1] protooncogene in human pulmonary epithelial cells using c-Jun , acting via a 12-O-tetradecanoylphorbol-13 acetate response element located at -318 . Positive_regulation FOSL2 EPHB2 11884386 929814 JNK is involved in c-Jun phosphorylation , whereas and p38 activities are *essential* for maximal c-Jun and [Fra-2] expression , and AP-1 DNA binding activity . Positive_regulation FOSL2 MAP2K6 9858556 582052 Using these cells , we show that activation of *leads* to the expression of Fra-1 and [Fra-2] but not c-Fos . Positive_regulation FOSL2 MAP2K6 9858557 582146 In cells expressing a conditionally active form of Raf-1 ( DeltaRaf-1 : ER ) , we observed that selective , sustained activation of was *sufficient* to induce expression of Fra-1 , [Fra-2] , and JunB but , interestingly , induced little or no c-Fos or c-Jun . Positive_regulation FOXA1 AP2A1 22577344 2598131 In one process , ErbB2 signaling genes CREB1 and c-Fos regulate FOXA1 transcription , and in another process , *regulates* the expression of both [FOXA1] and ErbB2 . Positive_regulation FOXA1 AP2M1 22577344 2598132 In one process , ErbB2 signaling genes CREB1 and c-Fos regulate FOXA1 transcription , and in another process , *regulates* the expression of both [FOXA1] and ErbB2 . Positive_regulation FOXA1 CYP2C19 10931833 743817 Transcription of a promoter-luciferase reporter gene in transfected HepG2 cells was *activated* 15-40-fold by the liver enriched [hepatocyte nuclear factor (HNF) 3 alpha] , HNF3 beta , and HNF6 . Positive_regulation FOXA1 FOXA2 12441652 1017088 In addition , overexpression of [Foxa1] increased the amount of vitronectin protein in the conditioned medium of Foxa1 overexpressed Neuro2a cells , but overexpression of only weakly *increased* it . Positive_regulation FOXA1 FOXA2 9685261 521701 was also *necessary* for expression of [HNF-3alpha] . Positive_regulation FOXA1 FOXD3 11891324 922764 Although *activated* the [FoxA1] and FoxA2 promoters , Oct-4 inhibited FoxD3 activation of the FoxA1 and FoxA2 endodermal promoters . Positive_regulation FOXA1 HEXIM1 24844355 2951069 Novel insight into the mechanistic basis for HEXIM1 inhibition of AR activity is provided by the present studies showing that induces expression of the histone demethylase KDM5B ( lysine-specific demethylase 5B ) and inhibits histone methylation , *resulting* in the inhibition of [FOXA1] ( forkhead box A1 ) licensing activity . Positive_regulation FOXA1 IFI27 17163418 1687961 We have recently identified transcriptional *activation* of by [FOXA1] . Positive_regulation FOXA1 IGF1 21882221 2524484 Together , these results demonstrate that can *increase* the stability of [FOXA1] protein expression and place it as a critical mediator of IGF-I regulation of gene expression and IGF-I mediated biological responses . Positive_regulation FOXA1 KDM5B 24802759 2950597 In mammary epithelial cells , JARID1B loss diminished the expression of key regulators for mammary morphogenesis and luminal lineage specification , including FOXA1 and estrogen receptor a. Mechanistically , was *required* for GATA3 recruitment to the Foxa1 promoter to activate [Foxa1] expression . Positive_regulation FOXA1 KLF5 23266329 2745806 *blocked* the decrease in [FoxA1] and Sox9 expression that accompanies normal villus morphogenesis . Positive_regulation FOXA1 MYLIP 24486549 2918551 The microRNA *regulates* lung [FoxA1] expression during lipopolysaccharide induced acute lung injury . Positive_regulation FOXA1 PAX4 11845228 912438 In contrast , *had* no effect on Cdx-2/3 or [HNF3alpha] mediated transcriptional activation . Positive_regulation FOXA1 SOX1 24213532 2892071 In this study , we showed that ectopic SCUBE2 overexpression could enhance the formation of E-cadherin containing adherens junctions by <ß-catenin-SOX> *mediated* induction of [forkhead box A1] ( a positive regulator of E-cadherin ) and upregulation of E-cadherin , which in turn led to epithelial transition and inhibited migration and invasion of aggressive MDA-MB-231 breast-carcinoma cells . Positive_regulation FOXA1 SOX10 24213532 2892072 In this study , we showed that ectopic SCUBE2 overexpression could enhance the formation of E-cadherin containing adherens junctions by <ß-catenin-SOX> mediated *induction* of [forkhead box A1] ( a positive regulator of E-cadherin ) and upregulation of E-cadherin , which in turn led to epithelial transition and inhibited migration and invasion of aggressive MDA-MB-231 breast-carcinoma cells . Positive_regulation FOXA1 SOX11 24213532 2892073 In this study , we showed that ectopic SCUBE2 overexpression could enhance the formation of E-cadherin containing adherens junctions by <ß-catenin-SOX> *mediated* induction of [forkhead box A1] ( a positive regulator of E-cadherin ) and upregulation of E-cadherin , which in turn led to epithelial transition and inhibited migration and invasion of aggressive MDA-MB-231 breast-carcinoma cells . Positive_regulation FOXA1 SOX12 24213532 2892080 In this study , we showed that ectopic SCUBE2 overexpression could enhance the formation of E-cadherin containing adherens junctions by <ß-catenin-SOX> *mediated* induction of [forkhead box A1] ( a positive regulator of E-cadherin ) and upregulation of E-cadherin , which in turn led to epithelial transition and inhibited migration and invasion of aggressive MDA-MB-231 breast-carcinoma cells . Positive_regulation FOXA1 SOX13 24213532 2892074 In this study , we showed that ectopic SCUBE2 overexpression could enhance the formation of E-cadherin containing adherens junctions by <ß-catenin-SOX> mediated *induction* of [forkhead box A1] ( a positive regulator of E-cadherin ) and upregulation of E-cadherin , which in turn led to epithelial transition and inhibited migration and invasion of aggressive MDA-MB-231 breast-carcinoma cells . Positive_regulation FOXA1 SOX14 24213532 2892075 In this study , we showed that ectopic SCUBE2 overexpression could enhance the formation of E-cadherin containing adherens junctions by <ß-catenin-SOX> *mediated* induction of [forkhead box A1] ( a positive regulator of E-cadherin ) and upregulation of E-cadherin , which in turn led to epithelial transition and inhibited migration and invasion of aggressive MDA-MB-231 breast-carcinoma cells . Positive_regulation FOXA1 SOX15 24213532 2892078 In this study , we showed that ectopic SCUBE2 overexpression could enhance the formation of E-cadherin containing adherens junctions by <ß-catenin-SOX> *mediated* induction of [forkhead box A1] ( a positive regulator of E-cadherin ) and upregulation of E-cadherin , which in turn led to epithelial transition and inhibited migration and invasion of aggressive MDA-MB-231 breast-carcinoma cells . Positive_regulation FOXA1 SOX17 24213532 2892087 In this study , we showed that ectopic SCUBE2 overexpression could enhance the formation of E-cadherin containing adherens junctions by <ß-catenin-SOX> mediated *induction* of [forkhead box A1] ( a positive regulator of E-cadherin ) and upregulation of E-cadherin , which in turn led to epithelial transition and inhibited migration and invasion of aggressive MDA-MB-231 breast-carcinoma cells . Positive_regulation FOXA1 SOX18 24213532 2892076 In this study , we showed that ectopic SCUBE2 overexpression could enhance the formation of E-cadherin containing adherens junctions by <ß-catenin-SOX> mediated *induction* of [forkhead box A1] ( a positive regulator of E-cadherin ) and upregulation of E-cadherin , which in turn led to epithelial transition and inhibited migration and invasion of aggressive MDA-MB-231 breast-carcinoma cells . Positive_regulation FOXA1 SOX2 24213532 2892077 In this study , we showed that ectopic SCUBE2 overexpression could enhance the formation of E-cadherin containing adherens junctions by <ß-catenin-SOX> *mediated* induction of [forkhead box A1] ( a positive regulator of E-cadherin ) and upregulation of E-cadherin , which in turn led to epithelial transition and inhibited migration and invasion of aggressive MDA-MB-231 breast-carcinoma cells . Positive_regulation FOXA1 SOX21 24213532 2892079 In this study , we showed that ectopic SCUBE2 overexpression could enhance the formation of E-cadherin containing adherens junctions by <ß-catenin-SOX> mediated *induction* of [forkhead box A1] ( a positive regulator of E-cadherin ) and upregulation of E-cadherin , which in turn led to epithelial transition and inhibited migration and invasion of aggressive MDA-MB-231 breast-carcinoma cells . Positive_regulation FOXA1 SOX3 24213532 2892081 In this study , we showed that ectopic SCUBE2 overexpression could enhance the formation of E-cadherin containing adherens junctions by <ß-catenin-SOX> mediated *induction* of [forkhead box A1] ( a positive regulator of E-cadherin ) and upregulation of E-cadherin , which in turn led to epithelial transition and inhibited migration and invasion of aggressive MDA-MB-231 breast-carcinoma cells . Positive_regulation FOXA1 SOX30 24213532 2892089 In this study , we showed that ectopic SCUBE2 overexpression could enhance the formation of E-cadherin containing adherens junctions by <ß-catenin-SOX> mediated *induction* of [forkhead box A1] ( a positive regulator of E-cadherin ) and upregulation of E-cadherin , which in turn led to epithelial transition and inhibited migration and invasion of aggressive MDA-MB-231 breast-carcinoma cells . Positive_regulation FOXA1 SOX4 24213532 2892082 In this study , we showed that ectopic SCUBE2 overexpression could enhance the formation of E-cadherin containing adherens junctions by <ß-catenin-SOX> *mediated* induction of [forkhead box A1] ( a positive regulator of E-cadherin ) and upregulation of E-cadherin , which in turn led to epithelial transition and inhibited migration and invasion of aggressive MDA-MB-231 breast-carcinoma cells . Positive_regulation FOXA1 SOX5 24213532 2892083 In this study , we showed that ectopic SCUBE2 overexpression could enhance the formation of E-cadherin containing adherens junctions by <ß-catenin-SOX> mediated *induction* of [forkhead box A1] ( a positive regulator of E-cadherin ) and upregulation of E-cadherin , which in turn led to epithelial transition and inhibited migration and invasion of aggressive MDA-MB-231 breast-carcinoma cells . Positive_regulation FOXA1 SOX6 24213532 2892086 In this study , we showed that ectopic SCUBE2 overexpression could enhance the formation of E-cadherin containing adherens junctions by <ß-catenin-SOX> *mediated* induction of [forkhead box A1] ( a positive regulator of E-cadherin ) and upregulation of E-cadherin , which in turn led to epithelial transition and inhibited migration and invasion of aggressive MDA-MB-231 breast-carcinoma cells . Positive_regulation FOXA1 SOX7 24213532 2892088 In this study , we showed that ectopic SCUBE2 overexpression could enhance the formation of E-cadherin containing adherens junctions by <ß-catenin-SOX> *mediated* induction of [forkhead box A1] ( a positive regulator of E-cadherin ) and upregulation of E-cadherin , which in turn led to epithelial transition and inhibited migration and invasion of aggressive MDA-MB-231 breast-carcinoma cells . Positive_regulation FOXA1 SOX8 24213532 2892084 In this study , we showed that ectopic SCUBE2 overexpression could enhance the formation of E-cadherin containing adherens junctions by <ß-catenin-SOX> *mediated* induction of [forkhead box A1] ( a positive regulator of E-cadherin ) and upregulation of E-cadherin , which in turn led to epithelial transition and inhibited migration and invasion of aggressive MDA-MB-231 breast-carcinoma cells . Positive_regulation FOXA1 SOX9 24213532 2892085 In this study , we showed that ectopic SCUBE2 overexpression could enhance the formation of E-cadherin containing adherens junctions by <ß-catenin-SOX> mediated *induction* of [forkhead box A1] ( a positive regulator of E-cadherin ) and upregulation of E-cadherin , which in turn led to epithelial transition and inhibited migration and invasion of aggressive MDA-MB-231 breast-carcinoma cells . Positive_regulation FOXA1 TFF1 10073575 594678 *Activation* of endogenous expression of by [HNF-3 alpha] and beta gene products was more than 1000 fold in the pancreatic cell line Capan-2 and fivefold in the gastric cell line MKN-45 , whereas the intestinal cell lines HUTU 80 and HT-29 displayed no effect . Positive_regulation FOXA2 FOXA1 10931833 743819 Transcription of a CYP2C12 promoter-luciferase reporter gene in transfected HepG2 cells was *activated* 15-40-fold by the liver enriched , [HNF3 beta] , and HNF6 . Positive_regulation FOXA2 FOXA1 11763995 887893 We demonstrate that adenovirus mediated increase of levels in F9 cells is *sufficient* to induce activation of endogenous [HNF-3beta] levels followed by increased TTR and Shh expression . Positive_regulation FOXA2 FOXA1 12441652 1017089 In addition , overexpression of increased the amount of vitronectin protein in the conditioned medium of Foxa1 overexpressed Neuro2a cells , but overexpression of [Foxa2] only weakly *increased* it . Positive_regulation FOXG1 FOXO1 19543511 2099237 mRNA levels were significantly higher in samples of non progressed patients ( P < 0.001 ) , but [FOXG1] were *enhanced* in those of progressed patients ( P=0.019 ) . Positive_regulation FOXK2 TNF 12759424 1091158 We demonstrate that mature [ILF] formation occurs in response to lumenal stimuli , including normal bacterial flora , and *requires* receptor I function . Positive_regulation FOXK2 TNF 15681742 1350868 [ILF] formation can occur de novo in response to luminal stimuli and *requires* LT-sufficient B lymphocytes and receptor I function for full maturation . Positive_regulation FOXM1 CCND1 18206647 1870579 In contrast , we now demonstrate that this LXL-motif is not required for the *activation* of [FOXM1c] by , cyclin E/Cdk and cyclin A/Cdk2 or for the repression of FOXM1c by p27 . Positive_regulation FOXM1 CCND1 23333330 2747080 *increases* the transcriptional activity of [FOXM1c] without phosphorylating FOXM1c . Positive_regulation FOXM1 CCND1 23333330 2747082 Anders et al. ( 2011 ) [ 11 ] reported that and cyclinD3/Cdk6 *enhance* the transcriptional activity of [FOXM1c] by phosphorylating its TAD . Positive_regulation FOXM1 CCND1 23333330 2747090 They defined 12 Cdk consensus sites as essential for the *activation* of [FOXM1c] by and cyclinD3/Cdk6 and stated that the 12 Cdk-sites are positioned within the TAD of FOXM1c . Positive_regulation FOXM1 CCND1 23333330 2747096 This study shows that the *activation* of [FOXM1c] by is lost without removal of any cyclin/Cdk site and gained without addition of any cyclin/Cdk site because it depends on a FOXM1c domain with no potential cyclin/Cdk site , namely on the interaction domain for the tumor suppressor RB , which binds to and represses FOXM1c . Positive_regulation FOXM1 CCND1 23333330 2747100 For this purpose , phosphorylates only RB , but not FOXM1c , so that cyclinD1/Cdk4 increases the transcriptional activity of FOXM1c without phosphorylating FOXM1c and *activates* [FOXM1c] independently of cyclin/Cdk phosphorylation sites in FOXM1c . Positive_regulation FOXM1 CCND1 23333330 2747102 In summary , this study changes the model of Anders et al. ( 2011 ) [ 11 ] completely because it disproves their central conclusion that and cyclinD3/Cdk6 *enhance* the transcriptional activity of [FOXM1c] by phosphorylating its TAD at the 12 Cdk-sites . Positive_regulation FOXM1 EPHB2 23285101 2711754 But inhibition of signaling by U0126 or PD98059 could *reduce* the level of [FOXM1] in GRB7 overexpressing ovarian cancer cells , suggesting that GRB7 , ERK and FOXM1 are regulated orderly . Positive_regulation FOXM1 FOXA1 7862129 296153 We also discuss the *role* of reduced expression in mediating decreased transcription of [HNF-3] target genes which respond negatively to cytokine signalling . Positive_regulation FOXM1 MAP2K6 15671063 1369658 signaling *stimulates* the nuclear translocation and transactivating activity of [FOXM1c] . Positive_regulation FOXM1 MAP2K6 15671063 1369679 Importantly , inhibition of signaling by U0126 *led* to suppression of [FOXM1] target gene expression and delayed progression through G2/M , verifying the functional relevance of FOXM1 activation by MEK1 . Positive_regulation FOXM1 MAP2K6 20694663 2305863 signaling *stimulates* the nuclear translocation and transactivating activity of [FOXM1] . Positive_regulation FOXM1 MAP2K6 23531216 2777527 Finally , xenograft studies demonstrated that combined pharmacological inhibition of plus lapatinib suppressed tumor growth and *reduced* expression of [FOXM1] in HER2 overexpressing breast cancers that are resistant to trastuzumab and lapatinib . Positive_regulation FOXM1 TNF 22831955 2687271 In the current study , we demonstrated that *induced* [FoxM1] expression and transactivated its promoter activity in hepatoma cells . Positive_regulation FOXM1 TNF 22831955 2687272 Serial 5 '' deletion and site directed mutagenesis revealed that the *induction* of [FoxM1] expression by was dependent upon the hypoxia-inducible factor 1 (HIF1)-1 and HIF1-3/4 binding sites within the FoxM1 promoter . Positive_regulation FOXM1 TNF 22831955 2687277 The inhibition of both HIF-1a expression and reactive oxygen species generation significantly decreased *induced* [FoxM1] overexpression . Positive_regulation FOXO1 AKT1 10358014 618626 We have examined the possible *role* of in the regulation of [FKHR] . Positive_regulation FOXO1 AKT1 10602488 574803 Importantly , Akt inhibited the translocation of FKHR to the nucleus , providing a mechanism by which might *regulate* the transcriptional activity of [FKHR] . Positive_regulation FOXO1 AKT1 10702299 672625 Neither site is required for insulin inhibition of promoter activity stimulated by the FKHR fragment , and overexpression of does not *inhibit* [FKHR] fragment stimulated Gal4 promoter activity . Positive_regulation FOXO1 AKT1 12172378 974370 These results suggest that the inactivation of *results* in the activation of [FKHR] and , in turn , relates to the expression of Fas ligand in the CA1 region after transient forebrain ischemia . Positive_regulation FOXO1 AKT1 12724332 1106602 *mediated* phosphorylation of [Foxo1] has been shown to result in the inhibition of target gene transcription and to trigger the export of Foxo1 from the nucleus , which is generally believed to explain the subsequent decrease of transcription . Positive_regulation FOXO1 AKT1 12969136 1139134 We conclude that PI 3-kinase and Akt are activated after renal ischemia/reperfusion and that phosphorylation *leads* to phosphorylation of [FKHR] and FKHRL1 , which may affect epithelial cell fate in acute renal failure . Positive_regulation FOXO1 AKT1 14727512 1181857 These results suggested that the inactivation of *results* in the activation of [FKHR] and , in turn , relates to the expression of Fas ligand in the hippocampal CA1 region after transient forebrain ischemia . Positive_regulation FOXO1 AKT1 15241468 1274057 Myc induced proliferation and transformation require *mediated* phosphorylation of [FoxO] proteins . Positive_regulation FOXO1 AKT1 15256269 1272084 The transcription factor [FKHR] ( FOXO1a ) is *regulated* by and insulin controls the expression of hepatic genes like glucose-6-phosphatase (G6Pase) at least in part via these proteins . Positive_regulation FOXO1 AKT1 15256269 1272091 The present data demonstrate that activation of is sufficient to mimic the effect of insulin on the expression of G6Pase and that [FKHR] *acts* as an activator of the G6Pase gene indicating that the established cellular models are suitable for the specific analysis of downstream targets of these signaling molecules . Positive_regulation FOXO1 AKT1 15688004 1382437 From these results we conclude that inhibition of and subsequent *activation* of [FoxO] transcription factors mediates an antiproliferative effect of cAMP . Positive_regulation FOXO1 AKT1 15917664 1445767 Activation of by growth factors *results* in phosphorylation of nuclear [FOXO] at specific sites followed by additional phosphorylations mediated by other kinases . Positive_regulation FOXO1 AKT1 16645158 1575250 However , rapamycin potently activates AKT dependent signaling , an effect that overrides the downregulation of this pathway by insulin resistance and that causes phosphorylation of the *dependent* transcription factor [FOXO1] . Positive_regulation FOXO1 AKT1 17433823 1728985 In response to E2 , phosphorylation of on Ser473 and FOXO1 on Ser256 and Thr24 residues increased but with distinct kinetics , *regulating* the activation and inactivation of Akt and [FOXO1] proteins , respectively . Positive_regulation FOXO1 AKT1 17972158 1850070 The activation of NF-kappaB through *induced* [FOXO1] phosphorylation during aging and its modulation by calorie restriction . Positive_regulation FOXO1 AKT1 18218983 1884192 Likewise , adenoviral mediated expression of *promotes* cardiomyocyte proliferation and cytoplasmic localization of [FOXO] . Positive_regulation FOXO1 AKT1 18644889 1942096 In conclusion , estradiol induced *dependent* phosphorylation of [FKHR] drives its association with ERalpha , thereby triggering complex export from the nucleus necessary for initiation of DNA synthesis and S phase entry . Positive_regulation FOXO1 AKT1 18787186 1976045 Incubation of human coronary artery endothelial cells with HGF induced prolonged *dependent* phosphorylation and nuclear exclusion of [FKHR/FOXO1] . Positive_regulation FOXO1 AKT1 18845636 2028583 These results indicate that FSH stimulated HIF-1 activation leading to up-regulation of targets such as vascular endothelial growth factor requires not only *mediated* activation of mammalian target of rapamycin as well as phosphorylation of [FOXO1] and possibly MDM2 but also a protein ( kinase ) activity that is inhibited by the classic ERK kinase inhibitor PD98059 but not ERK1/2 or 5 . Positive_regulation FOXO1 AKT1 18925359 2047084 Interestingly , activation of -- although coincident with a phosphorylation of Akt substrates , such as glycogen synthase kinase-3 -- did not *result* in significant nuclear exclusion of [FoxO1a] . Positive_regulation FOXO1 AKT1 18951090 1982497 this methylation directly blocked *mediated* phosphorylation of [FOXO1] at Ser253 in vitro and in vivo . Positive_regulation FOXO1 AKT1 19026986 2017148 Here we show that tumor necrosis factor (TNF)-alpha treatment attenuated *dependent* phosphorylation of [Foxo1] and enhanced transcriptional activity of Foxo1 . Positive_regulation FOXO1 AKT1 19470406 2097458 In this study , we found that TRAIL inhibited *dependent* [FoxO] phosphorylation and relocated FoxO proteins into the nucleus from the cytosol in activated human hepatic stellate LX-2 cells . Positive_regulation FOXO1 AKT1 19490822 2091326 Given the impact of insulin signaling on *mediated* phosphorylation of FOXO and the relatively high expression of [Foxo1] in insulin-responsive tissues , this transcription factor is highly poised to regulate energy metabolism . Positive_regulation FOXO1 AKT1 19513505 2092302 Inhibition of using RNA interference *resulted* in the accumulation of [FOXO1] in A549 and EBC1 cell nuclei , and in accelerated apoptosis induction . Positive_regulation FOXO1 AKT1 20041807 2211207 *induced* phosphorylation of [FOXO1] is required for its binding to PCAF , whereas the binding between FOXO1 and CBP is independent on FOXO1 S253 phosphorylation . Positive_regulation FOXO1 AKT1 20383191 2273587 CNK1 controls *dependent* phosphorylation and transcriptional activity of [FoxO] , which is a negative regulator of proliferation . Positive_regulation FOXO1 AKT1 20523723 2271298 Time resolved live imaging of *dependent* [FoxO1] phosphorylation revealed that miR-22 accelerated AKT activity upon growth factor stimulation , and attenuated its down regulation by serum withdrawal . Positive_regulation FOXO1 AKT1 20551062 2285040 Blocking the constitutively active by a specific Akt/protein kinase B signaling inhibitor-2 ( API-2 ) significantly *increased* [FOXO1A] expression and rendered the cells more responsive to trastuzumab induced growth inhibition . Positive_regulation FOXO1 AKT1 20657733 2293383 Our results also provide evidence that , as in bilaterian animals , Hydra [FoxO] activity is *regulated* by both and JNK kinases . Positive_regulation FOXO1 AKT1 21131554 2384214 Disrupting activity by the introduction of the dominant negative form of Akt *increased* nuclear [FOXO1] accumulation and enhanced the effect of progestin . Positive_regulation FOXO1 AKT1 21460183 2427979 activation *directs* phosphorylation and cytoplasmic sequestration of [FOXO] away from its target genes and serves as an endpoint of a complex signaling network . Positive_regulation FOXO1 AKT1 22019820 2507931 However , FHRE-Luc activation did not coincide with FoxO DNA binding or changes in *induced* [FoxO] phosphorylation after treatment with AhR agonists . Positive_regulation FOXO1 AKT1 22224971 2544531 In addition , Xanthigen may also stimulate insulin trigger signaling and result in *dependent* phosphorylation of [forkhead/winged helix O (FoxO)1] and FoxO3a . Positive_regulation FOXO1 AKT1 22515357 2584453 Inhibition of PI3K or kinase activity *reduced* [FoxO1/3a] phosphorylation . Positive_regulation FOXO1 AKT1 22552808 2618850 In conclusion , thrombin and FoxO factors functionally interact through *dependent* [FoxO] phosphorylation leading to expression of cell cycle regulating genes and ultimately SMC proliferation . Positive_regulation FOXO1 AKT1 22966017 2697784 Nuclear exclusion of FOXO1 was also detected in a subset of DLBCL without evidence of proximal BCR signaling suggesting that alternative mechanisms for activation may *mediate* [FOXO1] subcellular localization in these cases . Positive_regulation FOXO1 AKT1 23479511 2756261 Anti-HER3 domain 1 and 3 antibodies reduce tumor growth by hindering HER2/HER3 dimerization and *induced* MDM2 , XIAP , and [FoxO1] phosphorylation . Positive_regulation FOXO1 AKT1 24424889 2901237 Furthermore , MHY-449 reduced the phosphorylation of and FoxO1 and *induced* the translocation of [FoxO1] from cytoplasm to nucleus as shown by western blot analysis . Positive_regulation FOXO1 AKT1 24705403 2949471 *dependent* phosphorylation of hepatic [FoxO1] is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet induced obesity . Positive_regulation FOXO1 AKT1 24705403 2949486 Diminished *dependent* [FoxO1] phosphorylation was associated with reduced Akt activity associated with scaffold protein WD40/Propeller/FYVE ( WD40/ProF ) , which reportedly facilitates FoxO1 phosphorylation . Positive_regulation FOXO1 AKT1 24705403 2949489 We conclude that *dependent* [FoxO1] phosphorylation occurs on the WD/Propeller/FYVE scaffold in liver and is selectively inhibited in early DIO by diet induced increases in activity of cocompartmentalized aPKC . Positive_regulation FOXO1 AKT2 10358014 618627 We have examined the possible *role* of in the regulation of [FKHR] . Positive_regulation FOXO1 AKT2 10602488 574804 Importantly , Akt inhibited the translocation of FKHR to the nucleus , providing a mechanism by which might *regulate* the transcriptional activity of [FKHR] . Positive_regulation FOXO1 AKT2 10702299 672626 Neither site is required for insulin inhibition of promoter activity stimulated by the FKHR fragment , and overexpression of does not *inhibit* [FKHR] fragment stimulated Gal4 promoter activity . Positive_regulation FOXO1 AKT2 12172378 974371 These results suggest that the inactivation of *results* in the activation of [FKHR] and , in turn , relates to the expression of Fas ligand in the CA1 region after transient forebrain ischemia . Positive_regulation FOXO1 AKT2 12724332 1106603 *mediated* phosphorylation of [Foxo1] has been shown to result in the inhibition of target gene transcription and to trigger the export of Foxo1 from the nucleus , which is generally believed to explain the subsequent decrease of transcription . Positive_regulation FOXO1 AKT2 12969136 1139135 We conclude that PI 3-kinase and Akt are activated after renal ischemia/reperfusion and that phosphorylation *leads* to phosphorylation of [FKHR] and FKHRL1 , which may affect epithelial cell fate in acute renal failure . Positive_regulation FOXO1 AKT2 14727512 1181858 These results suggested that the inactivation of *results* in the activation of [FKHR] and , in turn , relates to the expression of Fas ligand in the hippocampal CA1 region after transient forebrain ischemia . Positive_regulation FOXO1 AKT2 15241468 1274058 Myc induced proliferation and transformation require *mediated* phosphorylation of [FoxO] proteins . Positive_regulation FOXO1 AKT2 15917664 1445768 Activation of by growth factors *results* in phosphorylation of nuclear [FOXO] at specific sites followed by additional phosphorylations mediated by other kinases . Positive_regulation FOXO1 AKT2 16645158 1575251 However , rapamycin potently activates AKT dependent signaling , an effect that overrides the downregulation of this pathway by insulin resistance and that causes phosphorylation of the *dependent* transcription factor [FOXO1] . Positive_regulation FOXO1 AKT2 17433823 1728986 In response to E2 , phosphorylation of on Ser473 and FOXO1 on Ser256 and Thr24 residues increased but with distinct kinetics , *regulating* the activation and inactivation of Akt and [FOXO1] proteins , respectively . Positive_regulation FOXO1 AKT2 17972158 1850071 The activation of NF-kappaB through *induced* [FOXO1] phosphorylation during aging and its modulation by calorie restriction . Positive_regulation FOXO1 AKT2 18218983 1884193 Likewise , adenoviral mediated expression of *promotes* cardiomyocyte proliferation and cytoplasmic localization of [FOXO] . Positive_regulation FOXO1 AKT2 18644889 1942097 In conclusion , estradiol induced *dependent* phosphorylation of [FKHR] drives its association with ERalpha , thereby triggering complex export from the nucleus necessary for initiation of DNA synthesis and S phase entry . Positive_regulation FOXO1 AKT2 18787186 1976046 Incubation of human coronary artery endothelial cells with HGF induced prolonged *dependent* phosphorylation and nuclear exclusion of [FKHR/FOXO1] . Positive_regulation FOXO1 AKT2 18845636 2028584 These results indicate that FSH stimulated HIF-1 activation leading to up-regulation of targets such as vascular endothelial growth factor requires not only *mediated* activation of mammalian target of rapamycin as well as phosphorylation of [FOXO1] and possibly MDM2 but also a protein ( kinase ) activity that is inhibited by the classic ERK kinase inhibitor PD98059 but not ERK1/2 or 5 . Positive_regulation FOXO1 AKT2 18925359 2047085 Interestingly , activation of -- although coincident with a phosphorylation of Akt substrates , such as glycogen synthase kinase-3 -- did not *result* in significant nuclear exclusion of [FoxO1a] . Positive_regulation FOXO1 AKT2 18951090 1982498 this methylation directly blocked *mediated* phosphorylation of [FOXO1] at Ser253 in vitro and in vivo . Positive_regulation FOXO1 AKT2 19026986 2017149 Here we show that tumor necrosis factor (TNF)-alpha treatment attenuated *dependent* phosphorylation of [Foxo1] and enhanced transcriptional activity of Foxo1 . Positive_regulation FOXO1 AKT2 19470406 2097459 In this study , we found that TRAIL inhibited *dependent* [FoxO] phosphorylation and relocated FoxO proteins into the nucleus from the cytosol in activated human hepatic stellate LX-2 cells . Positive_regulation FOXO1 AKT2 19490822 2091327 Given the impact of insulin signaling on *mediated* phosphorylation of FOXO and the relatively high expression of [Foxo1] in insulin-responsive tissues , this transcription factor is highly poised to regulate energy metabolism . Positive_regulation FOXO1 AKT2 19513505 2092303 Inhibition of using RNA interference *resulted* in the accumulation of [FOXO1] in A549 and EBC1 cell nuclei , and in accelerated apoptosis induction . Positive_regulation FOXO1 AKT2 20041807 2211208 *induced* phosphorylation of [FOXO1] is required for its binding to PCAF , whereas the binding between FOXO1 and CBP is independent on FOXO1 S253 phosphorylation . Positive_regulation FOXO1 AKT2 20383191 2273588 CNK1 controls *dependent* phosphorylation and transcriptional activity of [FoxO] , which is a negative regulator of proliferation . Positive_regulation FOXO1 AKT2 20523723 2271299 Time resolved live imaging of *dependent* [FoxO1] phosphorylation revealed that miR-22 accelerated AKT activity upon growth factor stimulation , and attenuated its down regulation by serum withdrawal . Positive_regulation FOXO1 AKT2 20551062 2285041 Blocking the constitutively active by a specific Akt/protein kinase B signaling inhibitor-2 ( API-2 ) significantly *increased* [FOXO1A] expression and rendered the cells more responsive to trastuzumab induced growth inhibition . Positive_regulation FOXO1 AKT2 20657733 2293384 Our results also provide evidence that , as in bilaterian animals , Hydra [FoxO] activity is *regulated* by both and JNK kinases . Positive_regulation FOXO1 AKT2 21131554 2384215 Disrupting activity by the introduction of the dominant negative form of Akt *increased* nuclear [FOXO1] accumulation and enhanced the effect of progestin . Positive_regulation FOXO1 AKT2 21460183 2427980 activation *directs* phosphorylation and cytoplasmic sequestration of [FOXO] away from its target genes and serves as an endpoint of a complex signaling network . Positive_regulation FOXO1 AKT2 22019820 2507932 However , FHRE-Luc activation did not coincide with FoxO DNA binding or changes in *induced* [FoxO] phosphorylation after treatment with AhR agonists . Positive_regulation FOXO1 AKT2 22224971 2544532 In addition , Xanthigen may also stimulate insulin trigger signaling and result in *dependent* phosphorylation of [forkhead/winged helix O (FoxO)1] and FoxO3a . Positive_regulation FOXO1 AKT2 22515357 2584454 Inhibition of PI3K or kinase activity *reduced* [FoxO1/3a] phosphorylation . Positive_regulation FOXO1 AKT2 22552808 2618851 In conclusion , thrombin and FoxO factors functionally interact through *dependent* [FoxO] phosphorylation leading to expression of cell cycle regulating genes and ultimately SMC proliferation . Positive_regulation FOXO1 AKT2 22966017 2697785 Nuclear exclusion of FOXO1 was also detected in a subset of DLBCL without evidence of proximal BCR signaling suggesting that alternative mechanisms for activation may *mediate* [FOXO1] subcellular localization in these cases . Positive_regulation FOXO1 AKT2 23479511 2756262 Anti-HER3 domain 1 and 3 antibodies reduce tumor growth by hindering HER2/HER3 dimerization and *induced* MDM2 , XIAP , and [FoxO1] phosphorylation . Positive_regulation FOXO1 AKT2 24424889 2901238 Furthermore , MHY-449 reduced the phosphorylation of and FoxO1 and *induced* the translocation of [FoxO1] from cytoplasm to nucleus as shown by western blot analysis . Positive_regulation FOXO1 AKT2 24705403 2949472 *dependent* phosphorylation of hepatic [FoxO1] is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet induced obesity . Positive_regulation FOXO1 AKT2 24705403 2949487 Diminished *dependent* [FoxO1] phosphorylation was associated with reduced Akt activity associated with scaffold protein WD40/Propeller/FYVE ( WD40/ProF ) , which reportedly facilitates FoxO1 phosphorylation . Positive_regulation FOXO1 AKT2 24705403 2949490 We conclude that *dependent* [FoxO1] phosphorylation occurs on the WD/Propeller/FYVE scaffold in liver and is selectively inhibited in early DIO by diet induced increases in activity of cocompartmentalized aPKC . Positive_regulation FOXO1 AKT3 10358014 618628 We have examined the possible *role* of in the regulation of [FKHR] . Positive_regulation FOXO1 AKT3 10602488 574805 Importantly , Akt inhibited the translocation of FKHR to the nucleus , providing a mechanism by which might *regulate* the transcriptional activity of [FKHR] . Positive_regulation FOXO1 AKT3 10702299 672627 Neither site is required for insulin inhibition of promoter activity stimulated by the FKHR fragment , and overexpression of does not *inhibit* [FKHR] fragment stimulated Gal4 promoter activity . Positive_regulation FOXO1 AKT3 12172378 974372 These results suggest that the inactivation of *results* in the activation of [FKHR] and , in turn , relates to the expression of Fas ligand in the CA1 region after transient forebrain ischemia . Positive_regulation FOXO1 AKT3 12724332 1106604 *mediated* phosphorylation of [Foxo1] has been shown to result in the inhibition of target gene transcription and to trigger the export of Foxo1 from the nucleus , which is generally believed to explain the subsequent decrease of transcription . Positive_regulation FOXO1 AKT3 12969136 1139136 We conclude that PI 3-kinase and Akt are activated after renal ischemia/reperfusion and that phosphorylation *leads* to phosphorylation of [FKHR] and FKHRL1 , which may affect epithelial cell fate in acute renal failure . Positive_regulation FOXO1 AKT3 14727512 1181859 These results suggested that the inactivation of *results* in the activation of [FKHR] and , in turn , relates to the expression of Fas ligand in the hippocampal CA1 region after transient forebrain ischemia . Positive_regulation FOXO1 AKT3 15241468 1274059 Myc induced proliferation and transformation require *mediated* phosphorylation of [FoxO] proteins . Positive_regulation FOXO1 AKT3 15917664 1445769 Activation of by growth factors *results* in phosphorylation of nuclear [FOXO] at specific sites followed by additional phosphorylations mediated by other kinases . Positive_regulation FOXO1 AKT3 16645158 1575252 However , rapamycin potently activates AKT dependent signaling , an effect that overrides the downregulation of this pathway by insulin resistance and that causes phosphorylation of the *dependent* transcription factor [FOXO1] . Positive_regulation FOXO1 AKT3 17433823 1728987 In response to E2 , phosphorylation of on Ser473 and FOXO1 on Ser256 and Thr24 residues increased but with distinct kinetics , *regulating* the activation and inactivation of Akt and [FOXO1] proteins , respectively . Positive_regulation FOXO1 AKT3 17972158 1850072 The activation of NF-kappaB through *induced* [FOXO1] phosphorylation during aging and its modulation by calorie restriction . Positive_regulation FOXO1 AKT3 18218983 1884194 Likewise , adenoviral mediated expression of *promotes* cardiomyocyte proliferation and cytoplasmic localization of [FOXO] . Positive_regulation FOXO1 AKT3 18644889 1942098 In conclusion , estradiol induced *dependent* phosphorylation of [FKHR] drives its association with ERalpha , thereby triggering complex export from the nucleus necessary for initiation of DNA synthesis and S phase entry . Positive_regulation FOXO1 AKT3 18787186 1976047 Incubation of human coronary artery endothelial cells with HGF induced prolonged *dependent* phosphorylation and nuclear exclusion of [FKHR/FOXO1] . Positive_regulation FOXO1 AKT3 18845636 2028585 These results indicate that FSH stimulated HIF-1 activation leading to up-regulation of targets such as vascular endothelial growth factor requires not only *mediated* activation of mammalian target of rapamycin as well as phosphorylation of [FOXO1] and possibly MDM2 but also a protein ( kinase ) activity that is inhibited by the classic ERK kinase inhibitor PD98059 but not ERK1/2 or 5 . Positive_regulation FOXO1 AKT3 18925359 2047086 Interestingly , activation of -- although coincident with a phosphorylation of Akt substrates , such as glycogen synthase kinase-3 -- did not *result* in significant nuclear exclusion of [FoxO1a] . Positive_regulation FOXO1 AKT3 18951090 1982499 this methylation directly blocked *mediated* phosphorylation of [FOXO1] at Ser253 in vitro and in vivo . Positive_regulation FOXO1 AKT3 19026986 2017150 Here we show that tumor necrosis factor (TNF)-alpha treatment attenuated *dependent* phosphorylation of [Foxo1] and enhanced transcriptional activity of Foxo1 . Positive_regulation FOXO1 AKT3 19470406 2097460 In this study , we found that TRAIL inhibited *dependent* [FoxO] phosphorylation and relocated FoxO proteins into the nucleus from the cytosol in activated human hepatic stellate LX-2 cells . Positive_regulation FOXO1 AKT3 19490822 2091328 Given the impact of insulin signaling on *mediated* phosphorylation of FOXO and the relatively high expression of [Foxo1] in insulin-responsive tissues , this transcription factor is highly poised to regulate energy metabolism . Positive_regulation FOXO1 AKT3 19513505 2092304 Inhibition of using RNA interference *resulted* in the accumulation of [FOXO1] in A549 and EBC1 cell nuclei , and in accelerated apoptosis induction . Positive_regulation FOXO1 AKT3 20041807 2211209 *induced* phosphorylation of [FOXO1] is required for its binding to PCAF , whereas the binding between FOXO1 and CBP is independent on FOXO1 S253 phosphorylation . Positive_regulation FOXO1 AKT3 20383191 2273589 CNK1 controls *dependent* phosphorylation and transcriptional activity of [FoxO] , which is a negative regulator of proliferation . Positive_regulation FOXO1 AKT3 20523723 2271300 Time resolved live imaging of *dependent* [FoxO1] phosphorylation revealed that miR-22 accelerated AKT activity upon growth factor stimulation , and attenuated its down regulation by serum withdrawal . Positive_regulation FOXO1 AKT3 20551062 2285042 Blocking the constitutively active by a specific Akt/protein kinase B signaling inhibitor-2 ( API-2 ) significantly *increased* [FOXO1A] expression and rendered the cells more responsive to trastuzumab induced growth inhibition . Positive_regulation FOXO1 AKT3 20657733 2293385 Our results also provide evidence that , as in bilaterian animals , Hydra [FoxO] activity is *regulated* by both and JNK kinases . Positive_regulation FOXO1 AKT3 21131554 2384216 Disrupting activity by the introduction of the dominant negative form of Akt *increased* nuclear [FOXO1] accumulation and enhanced the effect of progestin . Positive_regulation FOXO1 AKT3 21460183 2427981 activation *directs* phosphorylation and cytoplasmic sequestration of [FOXO] away from its target genes and serves as an endpoint of a complex signaling network . Positive_regulation FOXO1 AKT3 22019820 2507933 However , FHRE-Luc activation did not coincide with FoxO DNA binding or changes in *induced* [FoxO] phosphorylation after treatment with AhR agonists . Positive_regulation FOXO1 AKT3 22224971 2544533 In addition , Xanthigen may also stimulate insulin trigger signaling and result in *dependent* phosphorylation of [forkhead/winged helix O (FoxO)1] and FoxO3a . Positive_regulation FOXO1 AKT3 22515357 2584455 Inhibition of PI3K or kinase activity *reduced* [FoxO1/3a] phosphorylation . Positive_regulation FOXO1 AKT3 22552808 2618852 In conclusion , thrombin and FoxO factors functionally interact through *dependent* [FoxO] phosphorylation leading to expression of cell cycle regulating genes and ultimately SMC proliferation . Positive_regulation FOXO1 AKT3 22966017 2697786 Nuclear exclusion of FOXO1 was also detected in a subset of DLBCL without evidence of proximal BCR signaling suggesting that alternative mechanisms for activation may *mediate* [FOXO1] subcellular localization in these cases . Positive_regulation FOXO1 AKT3 23479511 2756263 Anti-HER3 domain 1 and 3 antibodies reduce tumor growth by hindering HER2/HER3 dimerization and *induced* MDM2 , XIAP , and [FoxO1] phosphorylation . Positive_regulation FOXO1 AKT3 24424889 2901239 Furthermore , MHY-449 reduced the phosphorylation of and FoxO1 and *induced* the translocation of [FoxO1] from cytoplasm to nucleus as shown by western blot analysis . Positive_regulation FOXO1 AKT3 24705403 2949473 *dependent* phosphorylation of hepatic [FoxO1] is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet induced obesity . Positive_regulation FOXO1 AKT3 24705403 2949488 Diminished *dependent* [FoxO1] phosphorylation was associated with reduced Akt activity associated with scaffold protein WD40/Propeller/FYVE ( WD40/ProF ) , which reportedly facilitates FoxO1 phosphorylation . Positive_regulation FOXO1 AKT3 24705403 2949491 We conclude that *dependent* [FoxO1] phosphorylation occurs on the WD/Propeller/FYVE scaffold in liver and is selectively inhibited in early DIO by diet induced increases in activity of cocompartmentalized aPKC . Positive_regulation FOXO1 APOA4 23729668 2811831 Mechanistic studies revealed that sequences between -204/-775 bp in the MTP promoter respond to apoAIV and that *enhances* expression of FoxA2 and [FoxO1] transcription factors and their binding to the identified cis elements in the MTP promoter at night . Positive_regulation FOXO1 AREG 17536007 1773148 However , *mediated* phosphorylation of PKB and [FOXO1a] required both EGFR and SFK activation . Positive_regulation FOXO1 BCR 12904304 1150456 Consistent with the idea that Rap-GTP is a negative regulator of the PI3K/Akt pathway , expressing constitutively active Rap2 ( Rap2V12 ) reduced *induced* phosphorylation of Akt and [FKHR] . Positive_regulation FOXO1 BCR 17202334 1680909 Previously , *induced* phosphorylation of [FOXO1] was shown to lead to a block in nuclear localization and subsequent protein degradation . Positive_regulation FOXO1 CALM3 24296716 2916761 Inhibition of P2 receptors or *blocked* ATPSß induced nuclear exclusion of [forkhead box O1] in liver cells . Positive_regulation FOXO1 CBFA2T2 19885597 2161169 Furthermore , depletion of PI3K *resulted* in significant activation of three [Forkhead box class O (FoxO)] transcription factors , which inhibited the expression of cyclin D1 , cdk4 and induced expression of p27/Kip1 . Positive_regulation FOXO1 CCR9 11493434 845844 This demonstrates that activation of *leads* to phosphorylation of GSK-3 beta and [FKHR] and provides a cell survival signal to the receptor expressing cells against CHX . Positive_regulation FOXO1 CD79A 12904304 1150457 Consistent with the idea that Rap-GTP is a negative regulator of the PI3K/Akt pathway , expressing constitutively active Rap2 ( Rap2V12 ) reduced *induced* phosphorylation of Akt and [FKHR] . Positive_regulation FOXO1 CD79B 12904304 1150458 Consistent with the idea that Rap-GTP is a negative regulator of the PI3K/Akt pathway , expressing constitutively active Rap2 ( Rap2V12 ) reduced *induced* phosphorylation of Akt and [FKHR] . Positive_regulation FOXO1 CDC25A 21670150 2460042 In this study , we revealed that *enhances* [Foxo1] stability by dephosphorylating Cdk2 , and Foxo1 was shown to directly regulate transcription of the metastatic factor MMP1 . Positive_regulation FOXO1 CDK1 18356527 1887680 *Activation* of [FOXO1] by in cycling cells and postmitotic neurons . Positive_regulation FOXO1 CDK1 18356527 1887682 In proliferating cells , *induced* [FOXO1] Ser249 phosphorylation at the G2/M phase of the cell cycle , resulting in FOXO1 dependent expression of the mitotic regulator Polo-like kinase (Plk) . Positive_regulation FOXO1 CDK2 17038621 1631020 *dependent* phosphorylation of [FOXO1] as an apoptotic response to DNA damage . Positive_regulation FOXO1 CDK4 23469153 2750282 Here we report that inhibition of by fascaplysin ( a small molecule selective inhibitor of Cdk4/cyclin D1 that we identified in a screen for compounds that inhibit PAX3-FOXO1 ) *led* to inhibition of the transcriptional activity of [PAX3-FOXO1] in ARMS cell line Rh30 . Positive_regulation FOXO1 CDK4 23469153 2750284 Our findings indicate that phosphorylates and positively *regulates* [PAX3-FOXO1] and suggest that inhibition of Cdk4 activity should be explored as a promising avenue for developing therapy for ARMS . Positive_regulation FOXO1 CDKN1A 11073996 748903 Furthermore , both PTEN and constitutively active [FKHR] *induce* p27 ( KIP1 ) protein but not . Positive_regulation FOXO1 CLDN5 24280217 2898641 Interleukin-4 *induces* up-regulation of endothelial cell through activation of [FoxO1] : role in protection from complement mediated injury . Positive_regulation FOXO1 CRK 17303659 1725978 In contrast , [Foxo1-ADA] increases p38 activity , and is *required* for effects of Foxo1 on PKB , at least in part . Positive_regulation FOXO1 CSNK1A1 14710188 1196807 Our results indicate that these residues are targeted by in vivo and that the CK1 mediated phosphorylation of the MPD is *required* for accelerated nuclear exclusion of [FOXO1a] in response to IGF-1 and insulin . Positive_regulation FOXO1 CTNNB1 15905404 1409230 binds directly to FOXO and *enhances* [FOXO] transcriptional activity in mammalian cells . Positive_regulation FOXO1 CTNNB1 18250171 1884719 , through binding , *enhances* [FOXO] transcriptional activity . Positive_regulation FOXO1 CXCL12 18786922 1980669 In examining the mechanism by which SDF-1 inhibits gluconeogenesis , we found that *promoted* phosphorylation of Akt , [FoxO1] , and c-Src , but did not activate insulin receptor substrate-1-like insulin . Positive_regulation FOXO1 DUSP6 22848439 2635872 The results indicate that phosphatase activity is not *required* for [MKP-3/FOXO1] interaction but is essential for FOXO1 nuclear translocation and MKP-3 promoted gluconeogenesis . Positive_regulation FOXO1 E2F1 17482685 1738749 *regulates* expression of [FOXO1] and FOXO3a . Positive_regulation FOXO1 E2F1 17482685 1738755 We found that expression of endogenous [FOXO1] and FOXO3a is *induced* by . Positive_regulation FOXO1 EDN1 22570335 2619217 In *response* to , [FOXO1] was phosphorylated and translocated from the nucleus to cytoplasm , resulting in inhibition of BAD production and mitigation of FOXO1 mediated apoptosis . Positive_regulation FOXO1 EDN1 22570335 2619219 These data reveal a mechanism by which [FOXO1] *mediated* the autocrine effect of on endothelial cell survival . Positive_regulation FOXO1 EGF 11030146 740085 FKHR immunoblotting after purification of nuclear and cytoplasmic proteins showed that *induced* a simultaneous increase of [FKHR] in the cytoplasm and decrease in the nucleus . Positive_regulation FOXO1 EGF 16020479 1453187 Phenylephrine , but not , *caused* nuclear translocation of [FOXO1] , a response that is associated with dephosphorylation . Positive_regulation FOXO1 EGFR 17536007 1773147 However , AREG mediated phosphorylation of PKB and [FOXO1a] *required* both and SFK activation . Positive_regulation FOXO1 EIF2AK2 20685959 2322801 In contrast , regulates IRS2 , another major IRS family protein in the liver , at the transcriptional rather than the posttranslational level , and this effect is *mediated* by the transcription factor , [FoxO1] , which has been previously shown to be regulated by insulin and plays a significant role in glucose homeostasis and energy metabolism . Positive_regulation FOXO1 ELOVL5 23099444 2717298 The Akt2 inhibitor Akti1/2 blocked *induction* of [FoxO1-S] ( 256 ) phosphorylation in HepG2 cells . Positive_regulation FOXO1 ELOVL5 23099444 2717301 Elevated Elovl5 activity in liver and HepG2 cells induced rictor mRNA , rictor protein , and rictor-mTOR interaction , whereas rictor knockdown ( siRNA ) attenuated *induction* of Akt2-S ( 473 ) and [FoxO1-S] ( 256 ) phosphorylation in HepG2 cells . Positive_regulation FOXO1 EPHB2 24424889 2901247 Taken together , these findings suggest that MHY-449 induces apoptosis via downregulation of the [Akt/FoxO1] and *activation* of in androgen independent , p53-null and PTEN negative PC3 human prostate cancer cells . Positive_regulation FOXO1 FAM3B 21412813 2432102 In cultured hepatocytes , overexpression induced lipid deposition , *increased* [FOXO1] expression , and suppressed insulin stimulated Akt activation and FOXO1 inactivation . Positive_regulation FOXO1 FBXO32 16051886 1447804 Skeletal muscle atrophy developed in wild-type mice 12 weeks following myocardial infarction accompanied by an increase in total protein ubiquitination and enhanced proteasome activity , *activation* of [Foxo] transcription factors , and robust induction of the ubiquitin-protein ligase . Positive_regulation FOXO1 FGFR4 20663909 2305259 We also provide the first direct evidence that and IGF1R are the *targets* for [PAX3-FKHR] . Positive_regulation FOXO1 FHL2 15692560 1376305 *enhanced* the interaction of [FOXO1] and SIRT1 and the deacetylation of FOXO1 by Sirtuin-1 (SIRT1) . Positive_regulation FOXO1 FOXA2 21385937 2416149 Interestingly , we demonstrated for the first time that could bind to the FoxO1 gene promoter and positively *regulate* [FoxO1] expression . Positive_regulation FOXO1 FOXA2 21385937 2416153 Together , the results of the present study demonstrated that could dynamically *regulate* [FoxO1] and PDX-1 expression in pancreatic ß-cells treated with DEX , which provides new important information on the transcriptional regulation of FoxO1 and PDX-1 in DEX induced pancreatic ß-cells . Positive_regulation FOXO1 FOXC1 17993506 1860077 *regulates* the expression of [FOXO1A] and binds to a conserved element in the FOXO1A promoter in vivo . Positive_regulation FOXO1 FOXO3 19244250 2054953 The transcription of [FOXO] genes is *stimulated* by and repressed by growth factors . Positive_regulation FOXO1 FOXO3 19244250 2055050 Conversely , ectopic activation blocked the proliferation of fibroblasts and *induced* the expression of [FOXO1] , FOXO4 , and p27-KIP1 . Positive_regulation FOXO1 FOXO3 19244250 2055052 Using luciferase reporter assays and chromatin immunoprecipitations , we identified a conserved FOXO binding site in the promoter of the FOXO1 gene , which was required for regulation by PDGF , and mediated the *up-regulation* of [FOXO1] by itself and by . Positive_regulation FOXO1 FOXO3 19244250 2055053 Altogether , our results suggest that the expression of [FOXO1] and FOXO4 genes is *stimulated* by and possibly by other FOXO factors in a positive feedback loop , which is disrupted by growth factors . Positive_regulation FOXO1 FOXO3 21109483 2383536 We also found that transcription of [FOXO1] and FOXO4 were *stimulated* by . Positive_regulation FOXO1 FOXO3 22931788 2701586 In this study , we showed that induced a transcription dependent autophagy , and [FOXO1] was *required* for this process . Positive_regulation FOXO1 FOXO3 22931788 2701588 Our data also showed that overexpression did not *increase* the expression of [FOXO1] at the protein level , although FOXO3 was capable of binding the promoter region of FOXO1 and inducing an increase in the transcription of FOXO1 mRNA . Positive_regulation FOXO1 FOXO3 22931788 2701589 Furthermore , our results showed that *promoted* the translocation of [FOXO1] from the nucleus to the cytoplasm , resulting in an increase in FOXO1 induced autophagy . Positive_regulation FOXO1 GAB1 19233262 2050601 Consistent with their opposite roles on Akt , the depletion of , but not of Gab2 , *results* in reduced [FOXO1] phosphorylation and VEGF mediated endothelial cell survival . Positive_regulation FOXO1 GADD45A 16012755 1431694 In response to oxidative stress , [FOXO] accumulates within the nucleus and *induces* expression . Positive_regulation FOXO1 GRAP2 20300563 2230420 By use of specific inhibitors , we demonstrated that both [FOXO1] activation and subsequent apoptosis was *mediated* , in part , by and JNK MAP kinases . Positive_regulation FOXO1 HDAC1 19074897 2003038 FOXO1 mediated inhibition of the AR is partially attenuated by the histone deacetylase (HDAC) inhibitor trichostatin A. Accordingly , [FOXO1] interacts with HDAC3 as shown by coimmunoprecipitation assays , and cotransfection of cells with FOXO1 and HDAC3 , but not and HDAC2 , *results* in a greater inhibition of AR activity than in cells transfected with FOXO1 or HDAC3 individually . Positive_regulation FOXO1 HDAC2 19074897 2003039 FOXO1 mediated inhibition of the AR is partially attenuated by the histone deacetylase (HDAC) inhibitor trichostatin A. Accordingly , [FOXO1] interacts with HDAC3 as shown by coimmunoprecipitation assays , and cotransfection of cells with FOXO1 and HDAC3 , but not HDAC1 and , *results* in a greater inhibition of AR activity than in cells transfected with FOXO1 or HDAC3 individually . Positive_regulation FOXO1 HSPB1 19528257 2142376 In contrast , *had* no effect on [Foxo] transactivation . Positive_regulation FOXO1 IGF1 11875118 918876 In naïve granulosa cells , both FSH and *stimulate* rapid phosphorylation of [FKHR] at multiple sites causing its redistribution from the nucleus to the cytoplasm in a PI3K dependent manner . Positive_regulation FOXO1 IGF1 12190109 979999 Des *increased* the phosphorylation of the transcription factor [FKHR] in cardiac muscle only ( p < 0.05 ) . Positive_regulation FOXO1 IGF1 12239091 989295 *increased* the phosphorylation of glycogen synthase kinase 3beta , BAD , [FKHR] , and p70 ( S6 ) kinase . Positive_regulation FOXO1 IGF1 12891709 1117766 However , did not *induce* phosphorylation of [FoxO1] on residues Thr24 and Ser316 . Positive_regulation FOXO1 IGF1 14710188 1196808 Our results indicate that these residues are targeted by CK1 in vivo and that the CK1 mediated phosphorylation of the MPD is required for accelerated nuclear exclusion of [FOXO1a] in *response* to and insulin . Positive_regulation FOXO1 IGF1 15961397 1440767 Under in vitro conditions , platelet derived growth factor (PDGF)-BB , tumor necrosis factor-alpha , and *stimulated* phosphorylation of [FoxO] in human coronary artery smooth muscle cells via MEK1/2 and/or phosphatidylinositol 3-kinase dependent signaling pathways . Positive_regulation FOXO1 IGF1 16133873 1450257 *induced* phosphorylation of Erks ( p42/p44 ) , [FKHR] ( FOXO1a ) ( Ser 253 ) , FKHRL1 ( FOXO3a ) ( Ser 256 ) , and Akt ( Ser 473 ) . Positive_regulation FOXO1 IGF1 16133873 1450267 PI3-K inhibitor , LY294002 , reduced *stimulated* phosphorylation of [FKHR] , FKHRL1 , and Akt , but did not affect Erk phosphorylation . Positive_regulation FOXO1 IGF1 18282106 1896448 Long lived daf-2 receptor mutants *require* both autophagy and the transcription factor [DAF-16/FOXO] for their longevity , but we find that autophagy takes place in the absence of DAF-16 . Positive_regulation FOXO1 IGF1 19787258 2141490 stimulation of serum starved cells *resulted* in rapid phosphorylation of Akt and [FOXO1] , and was associated with a significant increase in cell viability . Positive_regulation FOXO1 IGF1 20007517 2199904 and insulin *stimulated* phosphorylation of [FOXO1] and FOXO4 ( P < 0.05 ) , which was inhibited by the phosphatidylinositol 3-kinase ( PI 3-kinase ) inhibitor wortmannin , and decreased the abundance of polyubiquitinated proteins by 10-20 % ( P < 0.05 ) . Positive_regulation FOXO1 IGF1 21324320 2426291 Longevity increases when [FoxO] becomes activated in *response* to reduced signalling . Positive_regulation FOXO1 IGF1 21490365 2448469 We found that *induced* the phosphorylation of [FoxO1] and FoxO4 . Positive_regulation FOXO1 IGF1R 17210752 1681604 FOXO1 is a member of the forkhead transcriptional factor family , but how insulin and signaling *regulate* [FOXO1] in cardiomyocytes is not well understood . Positive_regulation FOXO1 IGF1R 17210752 1681608 In cardiomyocytes , activation of and insulin receptor *lead* to rapid phosphorylation of [FOXO1] . Positive_regulation FOXO1 IGF1R 20663909 2305260 We also provide the first direct evidence that FGFR4 and are the *targets* for [PAX3-FKHR] . Positive_regulation FOXO1 IGF1R 24933099 2952259 Pharmacological inhibition of modestly *attenuated* Cu-induced Akt and [FoxO] phosphorylation , whereas no attenuation of Cu-induced Akt activation was achieved by siRNA mediated IR depletion . Positive_regulation FOXO1 IGF2 20622751 2321772 The expression of was significantly down-regulated , but the expression of Foxo1 was simultaneously inversely increased , and the translocation of [Foxo1] from the cytoplasm to the nucleus was *induced* by rapamycin treatment . Positive_regulation FOXO1 IGFBP1 10385407 625439 When HEP G2 cells were cotransfected with FKHR expression vectors and with IGFBP-1 promoter plasmids containing either native or mutant IREs , [FKHR] expression *induced* a 5-fold increase in activity of the native promoter but no increase in activity of promoter constructs containing insulin unresponsive IRE mutants . Positive_regulation FOXO1 IGFBP1 11733864 885547 All FKHR forms stimulated IGFBP-1 promoter activity , and mutating any of the three FKHR PKB sites impaired the ability of insulin both to inhibit FKHR stimulated promoter activity and to *induce* [FKHR] accumulation in cytoplasm . Positive_regulation FOXO1 IGFBP7 24983498 2952610 interacted with FoxO1 and *activated* transcription of [FoxO1] target gene , p21 . Positive_regulation FOXO1 IL1A 23105097 2706990 Co-stimulation with insulin does not affect the *induction* of [FoxO1] . Positive_regulation FOXO1 IL1A 23105097 2706994 In conclusion , we propose that *regulates* [FoxO1] activity through a novel nSMase-2 dependent pathway . Positive_regulation FOXO1 IL2 17015685 1629793 Importantly , *induced* p27 kip1 down-regulation and cyclin D3 up-regulation and [FOXO1] phosphorylation were similar in Vav1 ( -/- ) and wild-type T lymphoblasts , indicating that defective FOXO1 phosphorylation and p27 kip1 and cyclin D3 expression do not result from deficient IL-2 signaling in the absence of Vav1 . Positive_regulation FOXO1 IL4 24280217 2898642 *induces* up-regulation of endothelial cell claudin-5 through activation of [FoxO1] : role in protection from complement mediated injury . Positive_regulation FOXO1 INS 10347145 616731 *stimulates* phosphorylation of the forkhead transcription factor [FKHR] on serine 253 through a Wortmannin-sensitive pathway . Positive_regulation FOXO1 INS 10347145 616739 *stimulated* phosphorylation of endogenous [FKHR] and of a recombinant c-Myc/FKHR fusion protein transiently expressed in murine SV40 transformed hepatocytes . Positive_regulation FOXO1 INS 10358076 618747 To our knowledge , these results provide the first report that [FKHR] stimulates promoter activity through an IRS and that phosphorylation of FKHR by PKB *mediates* effects of on gene expression . Positive_regulation FOXO1 INS 11672436 872456 However *induced* phosphorylation of PKB or [FKHR] is not affected by the presence of phorbol esters . Positive_regulation FOXO1 INS 11733864 885549 Thus , in hepatocytes as in other cell lines , all three FKHR PKB sites participate in *mediated* inhibition of FKHR action and in insulin mediated accumulation of [FKHR] in cytoplasm . Positive_regulation FOXO1 INS 11942857 953536 However , *induced* phosphorylation and regulation of protein kinase B , glycogen synthase kinase-3 and [FKHR] ( forkhead in rhabdomyosarcoma ) are not affected by H ( 2 ) O ( 2 ) in the same cells . Positive_regulation FOXO1 INS 12530968 1048846 The forkhead transcription factor [Foxo1] is *regulated* by via Akt dependent phosphorylation and nuclear exclusion . Positive_regulation FOXO1 INS 12724332 1106608 We conclude that the transcriptional activity of [Foxo1] is *regulated* at different levels by : transactivation , as well as DNA binding and nuclear exclusion . Positive_regulation FOXO1 INS 13679577 1143597 *induced* phosphorylation of [FKHR] ( Foxo1 ) targets to proteasomal degradation . Positive_regulation FOXO1 INS 13679577 1143598 [FKHR] is ubiquitinated in vivo and in vitro , and *enhances* the ubiquitination in the cells . Positive_regulation FOXO1 INS 13679577 1143599 These results demonstrate that the *induced* phosphorylation of [FKHR] leads to the multistep negative regulation , not only by the nuclear exclusion but also the ubiquitination mediated degradation . Positive_regulation FOXO1 INS 15059979 1251503 BADGP reversed the glucosamine induced reduction in *stimulated* phosphorylation of IR , IRS-1 , IRS-2 , Akt , GSK-3 , and [FOXO1a] . Positive_regulation FOXO1 INS 15256269 1272085 The transcription factor [FKHR] ( FOXO1a ) is *regulated* by protein kinase B (PKB) and controls the expression of hepatic genes like glucose-6-phosphatase (G6Pase) at least in part via these proteins . Positive_regulation FOXO1 INS 15691653 1371226 Forkhead box , class O ( FoxO ) transcription factors are inhibited by *induced* [FoxO] phosphorylation . Positive_regulation FOXO1 INS 16455781 1547962 In these same cells , inhibition of the insulin effect by rapamycin occurred in the presence of *induced* [Foxo1/Foxo3] phosphorylation . Positive_regulation FOXO1 INS 16455781 1547967 In contrast , 1 nm inhibited the IGFBP-1 mRNA level by 40 % and correspondingly *activated* Akt and [Foxo1/Foxo3] phosphorylation to a level comparable to that observed with 100 nM insulin . Positive_regulation FOXO1 INS 16644672 1553103 In contrast , LY294002 but not AG1478 suppressed *induced* [FoxO1] phosphorylation . Positive_regulation FOXO1 INS 16679294 1559334 Through the concomitant application of genome-scale functional screening and quantitative image analysis , we have identified PTP-MEG2 as a modulator of *dependent* [FOXO1] subcellular localization . Positive_regulation FOXO1 INS 16870142 1593046 Adenoviral mediated overexpression of forkhead transcription factor [Foxo1] increased angptl4 mRNA expression , and significantly *suppressed* its effect . Positive_regulation FOXO1 INS 16916938 1646388 By contrast , stimulation of Irs1 ( -/- ) MEFs *caused* [FoxO] degradation , not only because Irs2 expression increased but also because Irs2 efficiently activated p110alpha -- > Akt cascade . Positive_regulation FOXO1 INS 16916938 1646394 Importantly , prolonged stimulation *restored* [FoxO1] expression in wild-type or Irs1 ( -/- ) MEFs because Irs2 was degraded and Irs1 alone failed to activate sufficient p110alpha to promote the Akt -- > FoxO cascade . Positive_regulation FOXO1 INS 17210752 1681605 FOXO1 is a member of the forkhead transcriptional factor family , but how and IGF-I receptor signaling *regulate* [FOXO1] in cardiomyocytes is not well understood . Positive_regulation FOXO1 INS 17408630 1728352 Platelet derived growth factor ( PDGF ) or phosphorylates FoxO1 and *induces* [FoxO1] translocation from the nuclei to the cytosol via the PI3K/AKT pathway in HSCs . Positive_regulation FOXO1 INS 17416680 1742239 Although both groups on the high-fat diet developed insulin resistance , beta IRKO , but not beta IGFRKO , mice exhibited poor islet growth consistent with *stimulated* phosphorylation , nuclear exclusion of [FoxO1] , and reduced expression of Pdx-1 . Positive_regulation FOXO1 INS 17681146 1777508 This interaction enhances *stimulated* phosphorylation of [FOXO1] , which in turn regulates FOXO1 nuclear and cytosolic localization . Positive_regulation FOXO1 INS 18234213 1871309 The transcription factor FOXO1 has a central role in the regulation of glucose levels by insulin : reduced signaling *causes* [FOXO1] activation , which increases hepatic glucose production by activating transcription of phosphoenolpyruvate carboxykinase and glucose-6-phosphatase mRNAs . Positive_regulation FOXO1 INS 18282106 1896449 Long lived daf-2 receptor mutants *require* both autophagy and the transcription factor [DAF-16/FOXO] for their longevity , but we find that autophagy takes place in the absence of DAF-16 . Positive_regulation FOXO1 INS 18713797 1979795 Palmitate also reduced *stimulated* IR and IRS-2 tyrosine phosphorylation , IRS-2 associated PI 3-kinase activity , and phosphorylation of Akt , p70 S6 kinase , GSK-3 and [FOXO1A] . Positive_regulation FOXO1 INS 19246449 2062622 *induces* [FoxO1] phosphorylation and nuclear exportation , which prevents FoxO1-PPARgamma interactions and rescues transrepression . Positive_regulation FOXO1 INS 19273580 2063329 Results demonstrate that acute exercise improved insulin signalling , increasing *stimulated* Akt and [Foxo1] phosphorylation and decreasing PGC-1alpha expression and PGC-1alpha/Foxo1 interaction in the liver of diet induced obesity rats under fasting conditions . Positive_regulation FOXO1 INS 19463968 2128307 *caused* rapid exclusion of [FoxO1] from the nucleus and resulted in the induction of CYP7A1 mRNA expression , which was blocked by FoxO1-ADA . Positive_regulation FOXO1 INS 19651810 2150052 We studied the mechanism by which FoxO1 mediates *dependent* regulation of IL-1ß expression in cultured macrophages and correlated [FoxO1] activity in peritoneal macrophages with IL-1ß production profiles in mice with low-grade inflammation or insulin resistance . Positive_regulation FOXO1 INS 19877183 2187963 TACE overexpression significantly impaired *dependent* phosphorylation of AKT , GSK3 , and [FoxO1] in mouse hepatocytes . Positive_regulation FOXO1 INS 20007517 2199905 IGF-I and *stimulated* phosphorylation of [FOXO1] and FOXO4 ( P < 0.05 ) , which was inhibited by the phosphatidylinositol 3-kinase ( PI 3-kinase ) inhibitor wortmannin , and decreased the abundance of polyubiquitinated proteins by 10-20 % ( P < 0.05 ) . Positive_regulation FOXO1 INS 20216949 2223450 *dependent* phosphorylation or activation of insulin receptor , insulin receptor substrate-1 and -2 , phosphatidylinositol 3-kinase , Akt and [forkhead in rhabdomyosarcoma] were not affected by PQ pre-treatment . Positive_regulation FOXO1 INS 20357092 2260921 In this study , we observed that HCV infection of human hepatocytes impaired *induced* [FoxO1] translocation from the nucleus to the cytoplasm and significantly reduced accumulation of FoxA2 in the nucleus . Positive_regulation FOXO1 INS 20573950 2302947 Transcription factor [FoxO1] is *regulated* dually by and nutrients . Positive_regulation FOXO1 INS 21108932 2372136 In HepG2 cells , *stimulated* phosphorylation of Akt and [forkhead box O 1 (FoxO1)] was increased by Ky-2 . Positive_regulation FOXO1 INS 21152033 2356287 SRA in adipocytes increases both glucose uptake and phosphorylation of Akt and [FOXO1] in *response* to . Positive_regulation FOXO1 INS 21298325 2425817 Further analysis revealed that *regulates* nuclear localization of [FOXO1] , which is an important co-activator for STAT3 mediated transcription . Positive_regulation FOXO1 INS 21298325 2425819 *induced* nuclear exit and Thr24 phosphorylation of [FOXO1] , thus , inhibiting STAT3 mediated transcription . Positive_regulation FOXO1 INS 21324320 2426292 Longevity increases when [FoxO] becomes activated in *response* to reduced signalling . Positive_regulation FOXO1 INS 21460183 2427982 activation *directs* phosphorylation and cytoplasmic sequestration of [FOXO] away from its target genes and serves as an endpoint of a complex signaling network . Positive_regulation FOXO1 INS 21518241 2449083 Although extensively studied in Caenorhabditis elegans , no work has yet demonstrated for Drosophila melanogaster whether reduced *requires* the [FOXO transcription factor (foxo)] to extend lifespan . Positive_regulation FOXO1 INS 21632071 2494142 Hepatic *dependent* insulin receptor autophosphorylation , Akt activation , and [FoxO1] phosphorylation were similar between Lep ( db ) × IL6KO mice and Lep ( db ) controls . Positive_regulation FOXO1 INS 21846719 2486148 Moreover , liver-specific iNOS expression abrogated *stimulated* phosphorylation of glycogen synthase kinase-3ß , [forkhead box O1] , and mTOR ( mammalian target of rapamycin ) , endogenous substrates of Akt , along with increased S-nitrosylation of Akt relative to WT mice . Positive_regulation FOXO1 INS 21980302 2493061 Inhibition of signaling *results* in the activation of [DAF-16/FOXO] and SKN-1/Nrf transcription factors and increased animal fitness . Positive_regulation FOXO1 INS 22522094 2613654 Moreover , GOD disrupted insulin signaling both in rats and in hepatocytes , as evidenced by decreased phosphorylation of *stimulated* Akt , GSK3 and [FOXO1a] . Positive_regulation FOXO1 INS 22865884 2677406 We demonstrated that [FOXO1] is expressed in murine gonadotrope cells and that signaling *increased* FOXO1 phosphorylation and cytoplasmic localization in a PI3K dependent manner . Positive_regulation FOXO1 INS 22865884 2677421 In summary , we demonstrate that [FOXO1] phosphorylation and cellular localization is *regulated* by signaling in gonadotropes and that FOXO1 inhibits Lhb transcription . Positive_regulation FOXO1 INS 22933111 2715841 robustly *activated* AKT , GSK3ß , and [forkhead box class O (FOXO)1] in CON and IUGR fetal livers . Positive_regulation FOXO1 INS 23457303 2765808 In line with the in vivo results , *induced* AKT and [FoxO1] phosphorylation were potentiated by inhibition of Sirt1 in a cultured hypothalamic cell line . Positive_regulation FOXO1 INS 23757118 2865766 Furthermore , the addition of in vitro *prevented* the decrease in [Akt/Foxo] signaling induced by nutritional stress . Positive_regulation FOXO1 INS 24065703 2857762 Recently , we reported that *regulates* [FOXO1] phosphorylation and cellular localization in pituitary gonadotropes and that FOXO1 overexpression inhibits Lhb transcription . Positive_regulation FOXO1 INS 24329853 2894926 Moreover , we show that the enhanced PP2A expression is sufficient to inhibit *induced* [FoxO1] phosphorylation via blockade of insulin mediated Akt activation or/and through direct association and dephosphorylation of pS-FoxO1 . Positive_regulation FOXO1 INSR 17210752 1681609 In cardiomyocytes , activation of IGF-I receptor and *lead* to rapid phosphorylation of [FOXO1] . Positive_regulation FOXO1 IRS1 20028942 2210910 The absence of PTP1B in the double-mutant mice restored hepatic *mediated* phosphatidylinositol (PI) [3-kinase/Akt/Foxo1] signaling . Positive_regulation FOXO1 IRS1 20028942 2210916 Moreover , resveratrol treatment of hyperglycemic IRS2 ( -/- ) mice decreased hepatic PTP1B mRNA and inhibited PTP1B activity , thereby restoring *mediated* PI [3-kinase/Akt/Foxo1] signaling and peripheral insulin sensitivity . Positive_regulation FOXO1 IRS2 16916938 1646389 By contrast , insulin stimulation of Irs1 ( -/- ) MEFs caused [FoxO] degradation , not only because expression *increased* but also because Irs2 efficiently activated p110alpha -- > Akt cascade . Positive_regulation FOXO1 JUN 21604264 2562279 In addition , can *promote* [FOXO] nuclear localization , leading to apoptosis . Positive_regulation FOXO1 JUN 21901254 2539114 Knockdown of RON inhibits activity and *induces* apoptosis and cell cycle arrest through the modulation of [Akt/FoxO] signaling in human colorectal cancer cells . Positive_regulation FOXO1 JUN 21901254 2539121 These results indicate that knockdown of RON inhibits activity and *induces* apoptosis and cell cycle arrest through the modulation of [Akt/FoxO] signaling in human colorectal cancer cells . Positive_regulation FOXO1 LRRK2 20624856 2316449 *Activation* of [FoxO] by induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila . Positive_regulation FOXO1 MAOA 24865426 2945514 dependent activation of neuropilin-1 *promoted* [AKT/FOXO1/TWIST1] signaling , allowing FOXO1 binding at the TWIST1 promoter . Positive_regulation FOXO1 MAPK1 23426330 2776131 Thus , our findings support the hypothesis that the turnover of [FOXO1] *induced* by and XBP1u is a critical factor regulating the autophagic process . Positive_regulation FOXO1 MAPK8 19837872 2165154 PGE ( 2 ) -mediated activation , through dephosphorylation of Akt and FOXO1 , *leads* to nuclear accumulation of [FOXO1] and nucleocytoplasmic shuttling of PDX1 , finally resulting in defective GSIS in pancreatic beta-cells . Positive_regulation FOXO1 MET 15688035 1376228 We demonstrate here that [Pax3/FKHR] more potently *induces* a in SaOS-2 cells than Pax3 . Positive_regulation FOXO1 MIR223 22569260 2596965 *regulates* [FOXO1] expression and cell proliferation . Positive_regulation FOXO1 MLST8 18851840 1977033 Reduced activity in S4 ( -/- ) endothelial cells *results* in decreased [FoxO1/3a] and eNOS phosphorylation , decreased endothelial cell size , and increased arterial blood pressure in S4 ( -/- ) mice . Positive_regulation FOXO1 MSTN 18542002 1923580 Molecular analyses reveal that excess levels of induce Atrogin-1 expression by reducing Akt phosphorylation and thereby *increasing* [FoxO1] activity . Positive_regulation FOXO1 MTOR 18851840 1977035 Reduced activity in S4 ( -/- ) endothelial cells *results* in decreased [FoxO1/3a] and eNOS phosphorylation , decreased endothelial cell size , and increased arterial blood pressure in S4 ( -/- ) mice . Positive_regulation FOXO1 MTTP 18497882 1921940 They demonstrate that MTP is a target of the transcription factor FoxO1 and that excessive VLDL production associated with insulin resistance is caused by the inability of insulin to regulate [FoxO1] transcriptional *activation* of . Positive_regulation FOXO1 MTTP 18497885 1921941 In HepG2 cells , expression was *induced* by [FoxO1] and inhibited by exposure to insulin . Positive_regulation FOXO1 MUT 16135790 1450387 Here we show that binding is *required* for both the transcription of the noncoding RNAs and [Fkh1] binding . Positive_regulation FOXO1 MYC 15241468 1274060 induced proliferation and transformation *require* Akt mediated phosphorylation of [FoxO] proteins . Positive_regulation FOXO1 MYC 17974917 1820574 Moreover , constitutive signaling induces a marked *increase* in nuclear [FoxO] levels and stimulates binding of FoxO proteins to the Arf locus . Positive_regulation FOXO1 MYLIP 22569260 2596967 Therein , our data suggest that *regulates* [FOXO1] expression and cell proliferation . Positive_regulation FOXO1 MYLIP 24260486 2869633 Overexpression of in LNCaP cells *resulted* in a reduced [FOXO1] expression . Positive_regulation FOXO1 MYLIP 24374340 2911728 At the molecular level , our results further revealed that expression of [FOXO1] was negatively *regulated* by . Positive_regulation FOXO1 NCOA6 18462265 1979044 overexpression *increased* the expression of genes involved in signalling , such as IRS-1 , IRS-2 , IGF-II receptor or [Foxo1] , or of genes that control insulin secretion , such as Cplx2 , Glut2 or Kv3.1 in INS-1 cells . Positive_regulation FOXO1 NGF 21549807 2440468 Our data demonstrated that could *induce* the nuclear exclusion of [FoxO1-GFP] and FoxO3a-GFP in PC12 cells with different properties , but had no effect on FoxO6-GFP 's nuclear localization and FoxO6-GFP showed an exclusive nuclear localization . Positive_regulation FOXO1 NOTCH1 24302004 2899101 Inhibition of *prevented* amino acid induced insulin resistance , which was accompanied by reduced expression of Rbp-Jk , hairy and enhancer of split-1 , and [forkhead box O1] . Positive_regulation FOXO1 NOX4 21965295 2507417 We found that U-II and *stimulated* [FoxO] activity and identified matrix metalloproteinase-2 (MMP2) as target gene of FoxO3a . Positive_regulation FOXO1 NPPA 19837876 2165158 and 8-Br-cGMP *stimulated* the phosphorylation of Akt and [Foxo1a] in INS-1E cells and islets , and LY294002 inhibited these responses . Positive_regulation FOXO1 NR3C1 23435785 2794011 activation *stimulated* [Foxo1] transcription , but FOXO1 phosphorylation was unchanged and the cytosolic concentration of FOXO1 remained high in relation to its nuclear concentration . Positive_regulation FOXO1 NR3C1 24971545 2952485 Here we show that upregulation of [FoxO1] expression by glucocorticoids *requires* the and binding of hormones to it . Positive_regulation FOXO1 NRP1 24865426 2945515 MAOA dependent activation of *promoted* [AKT/FOXO1/TWIST1] signaling , allowing FOXO1 binding at the TWIST1 promoter . Positive_regulation FOXO1 PDGFB 15961397 1440768 Under in vitro conditions , , tumor necrosis factor-alpha , and insulin-like growth factor 1 *stimulated* phosphorylation of [FoxO] in human coronary artery smooth muscle cells via MEK1/2 and/or phosphatidylinositol 3-kinase dependent signaling pathways . Positive_regulation FOXO1 PDGFB 15961397 1440787 , tumor necrosis factor-alpha , and insulin-like growth factor 1 treatment *resulted* in the nuclear exclusion of [FoxO] , whereas PDGF-BB alone down-regulated the FoxO target gene , p27 ( kip1 ) , and enhanced cell survival and progression through the cell cycle . Positive_regulation FOXO1 PDK1 11980723 934938 IGF-1 stimulates the phosphorylation of Thr24 , Ser256 , Ser319 , Ser322 and Ser325 in embryonic stem ( ES ) cells , but not in PDK1-/- ES cells , providing genetic evidence that ( the upstream activator of PKB ) is *required* for the phosphorylation of [FKHR] in mammalian cells . Positive_regulation FOXO1 PGC 21972093 2492827 We conclude that decreased oxidative capacity and fiber atrophy in unloaded skeletal muscles are associated with decreased and *increased* [FOXO1] mRNA levels . Positive_regulation FOXO1 PGR 18096667 1883047 The regulation and function of the forkhead transcription factor , [Forkhead box O1] , is *dependent* on the in endometrial carcinoma . Positive_regulation FOXO1 PI3 10347145 616741 The effect of insulin was inhibited by wortmannin treatment , suggesting that activity is *required* for [FKHR] phosphorylation . Positive_regulation FOXO1 PI3 16457721 1534383 Long-term starvation and ageing induce *dependent* translocation of [DAF-16/FOXO] to the cytoplasm . Positive_regulation FOXO1 PI3 16781758 1599368 VLP induced activity *resulted* in efficient downstream signaling to Akt and consequent phosphorylation of [FKHR] and GSK3beta . Positive_regulation FOXO1 PI3 16916938 1646383 associated with Irs1 and Irs2 during insulin stimulation of wt MEFs , which strongly promoted Akt and FoxO phosphorylation , *led* to [FoxO] nuclear exclusion and degradation . Positive_regulation FOXO1 PI3 18718910 1974905 In the present study we hypothesized that DHEA may stimulate *dependent* phosphorylation of [FoxO1] in endothelial cells to help regulate endothelial function . Positive_regulation FOXO1 PI3 18845636 2028586 These results indicate that FSH stimulated HIF-1 activation leading to up-regulation of targets such as vascular endothelial growth factor requires not only *mediated* activation of mammalian target of rapamycin as well as phosphorylation of [FOXO1] and possibly MDM2 but also a protein ( kinase ) activity that is inhibited by the classic ERK kinase inhibitor PD98059 but not ERK1/2 or 5 . Positive_regulation FOXO1 PI3 21873430 2491442 Inhibition of *led* to a loss of Max/Mnt binding and transcriptional induction by MITF and USF1 , as well as [FoxO] . Positive_regulation FOXO1 PIK3CA 16133873 1450268 inhibitor , LY294002 , *reduced* IGF-I stimulated phosphorylation of [FKHR] , FKHRL1 , and Akt , but did not affect Erk phosphorylation . Positive_regulation FOXO1 PIK3CA 16731820 1566074 The use of inhibitors demonstrated that glucose induced [Foxo1] phosphorylation was *dependent* upon depolarization , calcium influx , and signaling . Positive_regulation FOXO1 PIK3CA 18787186 1976048 Incubation of human coronary artery endothelial cells with HGF induced prolonged *dependent* phosphorylation and nuclear exclusion of [FKHR/FOXO1] . Positive_regulation FOXO1 PIK3CA 19043547 1998898 however , neither the link between group II mGluRs and PI3K , nor the role of *dependent* regulation of [Foxo] in the control of neuronal excitability , had been previously reported . Positive_regulation FOXO1 PIK3CA 19470406 2097461 In this study , we found that TRAIL inhibited *dependent* [FoxO] phosphorylation and relocated FoxO proteins into the nucleus from the cytosol in activated human hepatic stellate LX-2 cells . Positive_regulation FOXO1 PIK3CA 19887561 2188358 We hypothesized that the *dependent* transcription factor [FOXO1] may mediate effects of EGCG to regulate expression of ET-1 in endothelial cells . Positive_regulation FOXO1 PIK3CA 21865646 2473424 By conditional inactivation of 3-phosphoinositide dependent protein kinase 1 ( Pdk1 ) and phosphatase and tensin homolog (Pten) in the male germ line , we found that signaling *regulates* [Foxo1] stability and subcellular localization , revealing that the Foxos are pivotal effectors of PI3K-Akt signaling in SSCs . Positive_regulation FOXO1 PIK3CA 22515357 2584456 Inhibition of or Akt kinase activity *reduced* [FoxO1/3a] phosphorylation . Positive_regulation FOXO1 PIK3CA 22552808 2618853 In conclusion , thrombin and FoxO factors functionally interact through *dependent* [FoxO] phosphorylation leading to expression of cell cycle regulating genes and ultimately SMC proliferation . Positive_regulation FOXO1 PIK3CA 22966017 2697787 Nuclear exclusion of FOXO1 was also detected in a subset of DLBCL without evidence of proximal BCR signaling suggesting that alternative mechanisms for activation may *mediate* [FOXO1] subcellular localization in these cases . Positive_regulation FOXO1 PIK3R1 16133873 1450269 inhibitor , LY294002 , *reduced* IGF-I stimulated phosphorylation of [FKHR] , FKHRL1 , and Akt , but did not affect Erk phosphorylation . Positive_regulation FOXO1 PIK3R1 16731820 1566075 The use of inhibitors demonstrated that glucose induced [Foxo1] phosphorylation was *dependent* upon depolarization , calcium influx , and signaling . Positive_regulation FOXO1 PIK3R1 18787186 1976049 Incubation of human coronary artery endothelial cells with HGF induced prolonged *dependent* phosphorylation and nuclear exclusion of [FKHR/FOXO1] . Positive_regulation FOXO1 PIK3R1 19043547 1998899 however , neither the link between group II mGluRs and PI3K , nor the role of *dependent* regulation of [Foxo] in the control of neuronal excitability , had been previously reported . Positive_regulation FOXO1 PIK3R1 19470406 2097462 In this study , we found that TRAIL inhibited *dependent* [FoxO] phosphorylation and relocated FoxO proteins into the nucleus from the cytosol in activated human hepatic stellate LX-2 cells . Positive_regulation FOXO1 PIK3R1 19887561 2188359 We hypothesized that the *dependent* transcription factor [FOXO1] may mediate effects of EGCG to regulate expression of ET-1 in endothelial cells . Positive_regulation FOXO1 PIK3R1 21865646 2473425 By conditional inactivation of 3-phosphoinositide dependent protein kinase 1 ( Pdk1 ) and phosphatase and tensin homolog (Pten) in the male germ line , we found that signaling *regulates* [Foxo1] stability and subcellular localization , revealing that the Foxos are pivotal effectors of PI3K-Akt signaling in SSCs . Positive_regulation FOXO1 PIK3R1 22515357 2584457 Inhibition of or Akt kinase activity *reduced* [FoxO1/3a] phosphorylation . Positive_regulation FOXO1 PIK3R1 22552808 2618854 In conclusion , thrombin and FoxO factors functionally interact through *dependent* [FoxO] phosphorylation leading to expression of cell cycle regulating genes and ultimately SMC proliferation . Positive_regulation FOXO1 PIK3R1 22966017 2697788 Nuclear exclusion of FOXO1 was also detected in a subset of DLBCL without evidence of proximal BCR signaling suggesting that alternative mechanisms for activation may *mediate* [FOXO1] subcellular localization in these cases . Positive_regulation FOXO1 PNMA3 23426330 2776130 Thus , our findings support the hypothesis that the turnover of [FOXO1] *induced* by and XBP1u is a critical factor regulating the autophagic process . Positive_regulation FOXO1 PPARGC1A 19103600 2036383 A transferase complex *regulates* [FoxO] transcription factor activity in response to glucose . Positive_regulation FOXO1 PPP2CA 19029949 2029318 associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is *involved* in calpain mediated [FoxO] regulation . Positive_regulation FOXO1 PPP2R1A 19029949 2029319 associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is *involved* in calpain mediated [FoxO] regulation . Positive_regulation FOXO1 PPP2R2B 19029949 2029320 associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is *involved* in calpain mediated [FoxO] regulation . Positive_regulation FOXO1 PRKAA1 18006475 1851639 Moreover , as the *dependent* phosphorylation and degradation of [FoxO1a] attenuates Ang-2 expression and protects against the pro-inflammatory actions of TNF-alpha , this kinase may be a useful target to prevent the progression of vascular diseases . Positive_regulation FOXO1 PRKAA1 19686213 2126312 phosphorylation *enhances* [FoxO] transcriptional activity , leading to the expression of specific target genes involved in stress resistance and changes in energy metabolism . Positive_regulation FOXO1 PRKAA1 19887561 2188360 EGCG induced nuclear exclusion of [FOXO1] , FOXO1 binding to the hET-1 promoter , and reduction of ET-1 expression was partially *inhibited* by the inhibitor Compound C. Basal ET-1 protein expression was enhanced by short interfering RNA knock-down of Akt and reduced by short interfering RNA knock-down of FOXO1 or adenovirus mediated expression of dominant negative Foxo1 . Positive_regulation FOXO1 PRKAA1 19887561 2188366 We conclude that EGCG decreases ET-1 expression and secretion from endothelial cells , in part , via Akt- and *stimulated* [FOXO1] regulation of the ET-1 promoter . Positive_regulation FOXO1 PRKAA1 20581852 2285566 Furthermore , activation *increased* the activity of transcription factor [FOXO1] and up-regulated downstream atrogene MuRF1 mRNA and protein expression . Positive_regulation FOXO1 PRKAA1 22186033 2563511 Moreover , *induced* stimulation of [FoxO/DAF-16] , Nrf2/SKN-1 , and SIRT1 signaling pathways improves cellular stress resistance . Positive_regulation FOXO1 PRKAA2 18006475 1851640 Moreover , as the *dependent* phosphorylation and degradation of [FoxO1a] attenuates Ang-2 expression and protects against the pro-inflammatory actions of TNF-alpha , this kinase may be a useful target to prevent the progression of vascular diseases . Positive_regulation FOXO1 PRKAA2 19686213 2126313 phosphorylation *enhances* [FoxO] transcriptional activity , leading to the expression of specific target genes involved in stress resistance and changes in energy metabolism . Positive_regulation FOXO1 PRKAA2 19887561 2188361 EGCG induced nuclear exclusion of [FOXO1] , FOXO1 binding to the hET-1 promoter , and reduction of ET-1 expression was partially *inhibited* by the inhibitor Compound C. Basal ET-1 protein expression was enhanced by short interfering RNA knock-down of Akt and reduced by short interfering RNA knock-down of FOXO1 or adenovirus mediated expression of dominant negative Foxo1 . Positive_regulation FOXO1 PRKAA2 19887561 2188367 We conclude that EGCG decreases ET-1 expression and secretion from endothelial cells , in part , via Akt- and *stimulated* [FOXO1] regulation of the ET-1 promoter . Positive_regulation FOXO1 PRKAA2 20581852 2285567 Furthermore , activation *increased* the activity of transcription factor [FOXO1] and up-regulated downstream atrogene MuRF1 mRNA and protein expression . Positive_regulation FOXO1 PRKAA2 22186033 2563512 Moreover , *induced* stimulation of [FoxO/DAF-16] , Nrf2/SKN-1 , and SIRT1 signaling pathways improves cellular stress resistance . Positive_regulation FOXO1 PRKAB1 18006475 1851641 Moreover , as the *dependent* phosphorylation and degradation of [FoxO1a] attenuates Ang-2 expression and protects against the pro-inflammatory actions of TNF-alpha , this kinase may be a useful target to prevent the progression of vascular diseases . Positive_regulation FOXO1 PRKAB1 19686213 2126314 phosphorylation *enhances* [FoxO] transcriptional activity , leading to the expression of specific target genes involved in stress resistance and changes in energy metabolism . Positive_regulation FOXO1 PRKAB1 19887561 2188362 EGCG induced nuclear exclusion of [FOXO1] , FOXO1 binding to the hET-1 promoter , and reduction of ET-1 expression was partially *inhibited* by the inhibitor Compound C. Basal ET-1 protein expression was enhanced by short interfering RNA knock-down of Akt and reduced by short interfering RNA knock-down of FOXO1 or adenovirus mediated expression of dominant negative Foxo1 . Positive_regulation FOXO1 PRKAB1 19887561 2188368 We conclude that EGCG decreases ET-1 expression and secretion from endothelial cells , in part , via Akt- and *stimulated* [FOXO1] regulation of the ET-1 promoter . Positive_regulation FOXO1 PRKAB1 20581852 2285568 Furthermore , activation *increased* the activity of transcription factor [FOXO1] and up-regulated downstream atrogene MuRF1 mRNA and protein expression . Positive_regulation FOXO1 PRKAB1 22186033 2563513 Moreover , *induced* stimulation of [FoxO/DAF-16] , Nrf2/SKN-1 , and SIRT1 signaling pathways improves cellular stress resistance . Positive_regulation FOXO1 PRKAB2 18006475 1851642 Moreover , as the *dependent* phosphorylation and degradation of [FoxO1a] attenuates Ang-2 expression and protects against the pro-inflammatory actions of TNF-alpha , this kinase may be a useful target to prevent the progression of vascular diseases . Positive_regulation FOXO1 PRKAB2 19686213 2126315 phosphorylation *enhances* [FoxO] transcriptional activity , leading to the expression of specific target genes involved in stress resistance and changes in energy metabolism . Positive_regulation FOXO1 PRKAB2 19887561 2188363 EGCG induced nuclear exclusion of [FOXO1] , FOXO1 binding to the hET-1 promoter , and reduction of ET-1 expression was partially *inhibited* by the inhibitor Compound C. Basal ET-1 protein expression was enhanced by short interfering RNA knock-down of Akt and reduced by short interfering RNA knock-down of FOXO1 or adenovirus mediated expression of dominant negative Foxo1 . Positive_regulation FOXO1 PRKAB2 19887561 2188369 We conclude that EGCG decreases ET-1 expression and secretion from endothelial cells , in part , via Akt- and *stimulated* [FOXO1] regulation of the ET-1 promoter . Positive_regulation FOXO1 PRKAB2 20581852 2285569 Furthermore , activation *increased* the activity of transcription factor [FOXO1] and up-regulated downstream atrogene MuRF1 mRNA and protein expression . Positive_regulation FOXO1 PRKAB2 22186033 2563514 Moreover , *induced* stimulation of [FoxO/DAF-16] , Nrf2/SKN-1 , and SIRT1 signaling pathways improves cellular stress resistance . Positive_regulation FOXO1 PRKAG1 18006475 1851643 Moreover , as the *dependent* phosphorylation and degradation of [FoxO1a] attenuates Ang-2 expression and protects against the pro-inflammatory actions of TNF-alpha , this kinase may be a useful target to prevent the progression of vascular diseases . Positive_regulation FOXO1 PRKAG1 19686213 2126316 phosphorylation *enhances* [FoxO] transcriptional activity , leading to the expression of specific target genes involved in stress resistance and changes in energy metabolism . Positive_regulation FOXO1 PRKAG1 19887561 2188364 EGCG induced nuclear exclusion of [FOXO1] , FOXO1 binding to the hET-1 promoter , and reduction of ET-1 expression was partially *inhibited* by the inhibitor Compound C. Basal ET-1 protein expression was enhanced by short interfering RNA knock-down of Akt and reduced by short interfering RNA knock-down of FOXO1 or adenovirus mediated expression of dominant negative Foxo1 . Positive_regulation FOXO1 PRKAG1 19887561 2188370 We conclude that EGCG decreases ET-1 expression and secretion from endothelial cells , in part , via Akt- and *stimulated* [FOXO1] regulation of the ET-1 promoter . Positive_regulation FOXO1 PRKAG1 20581852 2285570 Furthermore , activation *increased* the activity of transcription factor [FOXO1] and up-regulated downstream atrogene MuRF1 mRNA and protein expression . Positive_regulation FOXO1 PRKAG1 22186033 2563515 Moreover , *induced* stimulation of [FoxO/DAF-16] , Nrf2/SKN-1 , and SIRT1 signaling pathways improves cellular stress resistance . Positive_regulation FOXO1 PRKAG2 18006475 1851644 Moreover , as the *dependent* phosphorylation and degradation of [FoxO1a] attenuates Ang-2 expression and protects against the pro-inflammatory actions of TNF-alpha , this kinase may be a useful target to prevent the progression of vascular diseases . Positive_regulation FOXO1 PRKAG2 19686213 2126317 phosphorylation *enhances* [FoxO] transcriptional activity , leading to the expression of specific target genes involved in stress resistance and changes in energy metabolism . Positive_regulation FOXO1 PRKAG2 19887561 2188365 EGCG induced nuclear exclusion of [FOXO1] , FOXO1 binding to the hET-1 promoter , and reduction of ET-1 expression was partially *inhibited* by the inhibitor Compound C. Basal ET-1 protein expression was enhanced by short interfering RNA knock-down of Akt and reduced by short interfering RNA knock-down of FOXO1 or adenovirus mediated expression of dominant negative Foxo1 . Positive_regulation FOXO1 PRKAG2 19887561 2188371 We conclude that EGCG decreases ET-1 expression and secretion from endothelial cells , in part , via Akt- and *stimulated* [FOXO1] regulation of the ET-1 promoter . Positive_regulation FOXO1 PRKAG2 20581852 2285571 Furthermore , activation *increased* the activity of transcription factor [FOXO1] and up-regulated downstream atrogene MuRF1 mRNA and protein expression . Positive_regulation FOXO1 PRKAG2 22186033 2563516 Moreover , *induced* stimulation of [FoxO/DAF-16] , Nrf2/SKN-1 , and SIRT1 signaling pathways improves cellular stress resistance . Positive_regulation FOXO1 PRKG2 22393355 2566667 Biochemical assays using mammalian cGKII and FoxO1 reveal that *enhances* the transcriptional activity of [FoxO1] through phosphorylation of the FoxO1 S319 site in the same manner as LRRK2 . Positive_regulation FOXO1 PRL 16690806 1584263 When [FOXO1A] was overexpressed in human endometrial stromal cells , expression of IGFBP1 , DCN , and *increased* , whereas levels of TIMP3 and CNR1 decreased . Positive_regulation FOXO1 PTEN 22807038 2719605 *mediated* [Akt/ß-catenin/Foxo1] signaling regulates innate immune responses in mouse liver ischemia/reperfusion injury . Positive_regulation FOXO1 PTMS 20567500 2280157 [FOXO] activity is *regulated* by multiple that affect its subcellular localization , half-life , DNA binding and transcriptional activity . Positive_regulation FOXO1 QKI 24398626 2906914 Importantly , the ATRA induced increase in [FOXO1] expression was *dependent* on mediated post-transcriptional regulation . Positive_regulation FOXO1 RALA 15538382 1343220 [FOXO] transcription factor activation by oxidative stress *mediated* by the small GTPase and JNK . Positive_regulation FOXO1 RENBP 16457721 1534384 Long-term starvation and ageing induce 3-kinase *dependent* translocation of [DAF-16/FOXO] to the cytoplasm . Positive_regulation FOXO1 RENBP 19818798 2159770 PEDF inactivated the *induced* [PI3K/Akt/FKHR] activity and induced apoptosis via caspase-3 . Positive_regulation FOXO1 RENBP 19818798 2159782 The results reveal that PEDF inhibits *induced* [PI3K/Akt/FKHR] signaling in PRECs . Positive_regulation FOXO1 RETN 24291305 2898898 These observations indicate that the action of FOXO1 on gene expression *requires* the activation of [FOXO1] and that the effect of FOXO1 depends on the phosphorylation and dephosphorylation of FOXO1 . Positive_regulation FOXO1 RICTOR 18851840 1977034 Reduced activity in S4 ( -/- ) endothelial cells *results* in decreased [FoxO1/3a] and eNOS phosphorylation , decreased endothelial cell size , and increased arterial blood pressure in S4 ( -/- ) mice . Positive_regulation FOXO1 SCGB1D4 18067683 1836272 Several interventions increase lifespan in model organisms , including reduced insulin/insulin-like growth factor-like signaling ( ) , [FOXO] transcription factor *activation* , dietary restriction , and superoxide dismutase (SOD) over-expression . Positive_regulation FOXO1 SCGB1D4 20178781 2236753 Whereas *promotes* the cytoplasmic sequestration of [DAF-16/FoxO] , HSD-1 inhibits nuclear DAF-16/FoxO activity without affecting DAF-16/FoxO subcellular localization . Positive_regulation FOXO1 SETD2 18845636 2028582 These results indicate that FSH stimulated activation leading to up-regulation of targets such as vascular endothelial growth factor *requires* not only PI3-kinase/AKT mediated activation of mammalian target of rapamycin as well as phosphorylation of [FOXO1] and possibly MDM2 but also a protein ( kinase ) activity that is inhibited by the classic ERK kinase inhibitor PD98059 but not ERK1/2 or 5 . Positive_regulation FOXO1 SFN 20642839 2297548 Phosphorylation deficient mutants of FOXO proteins enhanced FOXO transcriptional activity , and further enhanced *induced* [FOXO] activity and apoptosis . Positive_regulation FOXO1 SFN 20642839 2297569 These data suggest that inhibition of PI3K/AKT and ERK pathways acts together to activate FOXO transcription factor and enhances *induced* [FOXO] transcriptional activity , leading to cell cycle arrest and apoptosis . Positive_regulation FOXO1 SIRT1 17090532 1660953 We propose that low expression of and Foxo1 *leads* to impaired [Foxo1-C/EBPalpha] complex formation , which contributes to the diminished adiponectin expression in obesity and type 2 diabetes . Positive_regulation FOXO1 SIRT1 18077353 1836820 Resveratrol , an activator of , *increases* the transcriptional activity of [FoxO1] and triggers Akt phosphorylation in heart . Positive_regulation FOXO1 SIRT1 18423418 1915250 We report that treatment of EPCs with high glucose for 3 days determined a consistent downregulation of EPC positive to DiLDL/lectin staining and , interestingly , this was associated with reduced expression levels and enzyme activity , and *increased* [acetyl-FoxO1] expression levels . Positive_regulation FOXO1 SIRT1 18849969 1988620 In view of the reciprocal *activation* of [FOXO1] and its coactivator peroxisome proliferator activated receptor-gamma coactivator-1alpha ( PGC-1alpha , encoded by Ppargc1a ) by activators , our results illustrate how the exchange of two gluconeogenic regulators during fasting maintains energy balance . Positive_regulation FOXO1 SIRT1 20971845 2376078 The NAD dependent protein deacetylase is *involved* in the protection against oxidative stress by enhancing [FOXO-driven] Sod2 transcription . Positive_regulation FOXO1 SIRT1 22733486 2634275 Treatment with the sirtuin agonist resveratrol , with an increase in the expression of , significantly *increased* [FoxO1] activity in diabetic kidney . Positive_regulation FOXO1 SIRT1 22956852 2667703 In Caenorhabditis elegans , overexpression protects neurons from the early phases of expanded polyglutamine ( polyQ ) toxicity , and this protection *requires* the longevity promoting factor [daf-16/FOXO] . Positive_regulation FOXO1 SIRT1 23763570 2882290 In addition , inhibition *reduced* both the nuclear [FoxO1] levels and MRP2 expression and enhanced cytotoxic effects of paclitaxel and doxorubicin in TAMR-MCF-7 cells . Positive_regulation FOXO1 SIRT2 17521387 1767189 hence *increases* [FOXO] DNA binding and elevates the expression of FOXO target genes , p27 ( Kip1 ) , manganese superoxide dismutase and Bim . Positive_regulation FOXO1 SKP2 15668399 1369623 Here we demonstrate that , an oncogenic subunit of the Skp1/Cul1/F-box protein ubiquitin complex , interacts with , ubiquitinates , and *promotes* the degradation of [FOXO1] . Positive_regulation FOXO1 SKP2 15668399 1369624 This effect of *requires* Akt-specific phosphorylation of [FOXO1] at Ser-256 . Positive_regulation FOXO1 SKP2 18096667 1883048 Using small interfering RNA technology , we demonstrated that the low levels of [FOXO1] protein were *due* to the involvement of , an oncogenic subunit of the Skp1/Cul1/F-box protein ubiquitin complex , given that silencing Skp2 increased FOXO1 protein expression in Ishikawa cells . Positive_regulation FOXO1 SMAD3 21964591 2497828 Based on presented data we propose a model whereby myostatin induces skeletal muscle wasting through targeting sarcomeric proteins via *mediated* up-regulation of Atrogin-1 and [forkhead box O1] . Positive_regulation FOXO1 STAT3 21730069 2471510 We further show that STAT3 binds directly to FoxO1 or FoxO3a promoter and that *resulted* in down-regulation of the expression of FoxO1 , FoxO3a and [FoxO-target] genes ( I?B and p27Kip1 ) . Positive_regulation FOXO1 STK10 21212262 2391946 The MST1 is a that is activated upon apoptotic stimulation , which in turn *activates* its downstream targets , JNK/p38 , histone H2B and [FOXO] . Positive_regulation FOXO1 STK11 21212262 2391947 The MST1 is a that is activated upon apoptotic stimulation , which in turn *activates* its downstream targets , JNK/p38 , histone H2B and [FOXO] . Positive_regulation FOXO1 STK16 21212262 2391948 The MST1 is a that is activated upon apoptotic stimulation , which in turn *activates* its downstream targets , JNK/p38 , histone H2B and [FOXO] . Positive_regulation FOXO1 STK19 21212262 2391949 The MST1 is a that is activated upon apoptotic stimulation , which in turn *activates* its downstream targets , JNK/p38 , histone H2B and [FOXO] . Positive_regulation FOXO1 STK24 21212262 2391950 The MST1 is a that is activated upon apoptotic stimulation , which in turn *activates* its downstream targets , JNK/p38 , histone H2B and [FOXO] . Positive_regulation FOXO1 STK25 21212262 2391951 The MST1 is a that is activated upon apoptotic stimulation , which in turn *activates* its downstream targets , JNK/p38 , histone H2B and [FOXO] . Positive_regulation FOXO1 STK3 21212262 2391952 The MST1 is a that is activated upon apoptotic stimulation , which in turn *activates* its downstream targets , JNK/p38 , histone H2B and [FOXO] . Positive_regulation FOXO1 STK31 21212262 2391953 The MST1 is a that is activated upon apoptotic stimulation , which in turn *activates* its downstream targets , JNK/p38 , histone H2B and [FOXO] . Positive_regulation FOXO1 STK33 21212262 2391955 The MST1 is a that is activated upon apoptotic stimulation , which in turn *activates* its downstream targets , JNK/p38 , histone H2B and [FOXO] . Positive_regulation FOXO1 STK35 21212262 2391956 The MST1 is a that is activated upon apoptotic stimulation , which in turn *activates* its downstream targets , JNK/p38 , histone H2B and [FOXO] . Positive_regulation FOXO1 STK36 21212262 2391957 The MST1 is a that is activated upon apoptotic stimulation , which in turn *activates* its downstream targets , JNK/p38 , histone H2B and [FOXO] . Positive_regulation FOXO1 STK38 21212262 2391959 The MST1 is a that is activated upon apoptotic stimulation , which in turn *activates* its downstream targets , JNK/p38 , histone H2B and [FOXO] . Positive_regulation FOXO1 STK39 21212262 2391958 The MST1 is a that is activated upon apoptotic stimulation , which in turn *activates* its downstream targets , JNK/p38 , histone H2B and [FOXO] . Positive_regulation FOXO1 STK4 18510339 2008757 We also identify autophosphorylation sites within the MST1 regulatory region and show that both regulatory region phosphorylation and dimerization *contribute* to [FoxO] phosphorylation . Positive_regulation FOXO1 STK4 19221179 2061636 Here , we show that *induced* phosphorylation of [FOXO1] at serine 212 , corresponding to serine 207 in FOXO3 , disrupts the association of FOXO1 with 14-3-3 proteins . Positive_regulation FOXO1 STK4 19221179 2061637 Accordingly , *mediates* the nuclear translocation of [FOXO1] in primary rat cerebellar granule neurons that are deprived of neuronal activity . Positive_regulation FOXO1 STK4 21212262 2391954 The MST1 is a that is activated upon apoptotic stimulation , which in turn *activates* its downstream targets , JNK/p38 , histone H2B and [FOXO] . Positive_regulation FOXO1 STK4 24453252 2912998 Mechanistic studies reveal that *enhances* [Foxo1/3] stability directly by phosphorylating Foxo1/3 and indirectly by attenuating TCR induced Akt activation in peripheral T cells . Positive_regulation FOXO1 STK40 21212262 2391960 The MST1 is a that is activated upon apoptotic stimulation , which in turn *activates* its downstream targets , JNK/p38 , histone H2B and [FOXO] . Positive_regulation FOXO1 TCF12 23555761 2767416 We hypothesized that the peroxisome proliferator activated receptor ß/d ( PPARß/d ) *upregulates* muscle [FOXO1] expression and activity with a downstream upregulation of atrogin-1 and MuRF1 expression during sepsis and glucocorticoid treatment and that inhibition of PPARß/d activity can prevent muscle wasting . Positive_regulation FOXO1 TCF15 23555761 2767417 We hypothesized that the peroxisome proliferator activated receptor ß/d ( PPARß/d ) *upregulates* muscle [FOXO1] expression and activity with a downstream upregulation of atrogin-1 and MuRF1 expression during sepsis and glucocorticoid treatment and that inhibition of PPARß/d activity can prevent muscle wasting . Positive_regulation FOXO1 TCF19 23555761 2767418 We hypothesized that the peroxisome proliferator activated receptor ß/d ( PPARß/d ) *upregulates* muscle [FOXO1] expression and activity with a downstream upregulation of atrogin-1 and MuRF1 expression during sepsis and glucocorticoid treatment and that inhibition of PPARß/d activity can prevent muscle wasting . Positive_regulation FOXO1 TCF20 23555761 2767419 We hypothesized that the peroxisome proliferator activated receptor ß/d ( PPARß/d ) *upregulates* muscle [FOXO1] expression and activity with a downstream upregulation of atrogin-1 and MuRF1 expression during sepsis and glucocorticoid treatment and that inhibition of PPARß/d activity can prevent muscle wasting . Positive_regulation FOXO1 TCF21 23555761 2767420 We hypothesized that the peroxisome proliferator activated receptor ß/d ( PPARß/d ) *upregulates* muscle [FOXO1] expression and activity with a downstream upregulation of atrogin-1 and MuRF1 expression during sepsis and glucocorticoid treatment and that inhibition of PPARß/d activity can prevent muscle wasting . Positive_regulation FOXO1 TCF23 23555761 2767424 We hypothesized that the peroxisome proliferator activated receptor ß/d ( PPARß/d ) *upregulates* muscle [FOXO1] expression and activity with a downstream upregulation of atrogin-1 and MuRF1 expression during sepsis and glucocorticoid treatment and that inhibition of PPARß/d activity can prevent muscle wasting . Positive_regulation FOXO1 TCF24 23555761 2767426 We hypothesized that the peroxisome proliferator activated receptor ß/d ( PPARß/d ) *upregulates* muscle [FOXO1] expression and activity with a downstream upregulation of atrogin-1 and MuRF1 expression during sepsis and glucocorticoid treatment and that inhibition of PPARß/d activity can prevent muscle wasting . Positive_regulation FOXO1 TCF25 23555761 2767425 We hypothesized that the peroxisome proliferator activated receptor ß/d ( PPARß/d ) *upregulates* muscle [FOXO1] expression and activity with a downstream upregulation of atrogin-1 and MuRF1 expression during sepsis and glucocorticoid treatment and that inhibition of PPARß/d activity can prevent muscle wasting . Positive_regulation FOXO1 TCF3 23555761 2767421 We hypothesized that the peroxisome proliferator activated receptor ß/d ( PPARß/d ) *upregulates* muscle [FOXO1] expression and activity with a downstream upregulation of atrogin-1 and MuRF1 expression during sepsis and glucocorticoid treatment and that inhibition of PPARß/d activity can prevent muscle wasting . Positive_regulation FOXO1 TCF4 23555761 2767422 We hypothesized that the peroxisome proliferator activated receptor ß/d ( PPARß/d ) *upregulates* muscle [FOXO1] expression and activity with a downstream upregulation of atrogin-1 and MuRF1 expression during sepsis and glucocorticoid treatment and that inhibition of PPARß/d activity can prevent muscle wasting . Positive_regulation FOXO1 TCF7 23555761 2767423 We hypothesized that the peroxisome proliferator activated receptor ß/d ( PPARß/d ) *upregulates* muscle [FOXO1] expression and activity with a downstream upregulation of atrogin-1 and MuRF1 expression during sepsis and glucocorticoid treatment and that inhibition of PPARß/d activity can prevent muscle wasting . Positive_regulation FOXO1 TCF7L2 19386626 2089265 Loss of *resulted* in decreased GLP-1 and GIP stimulated AKT phosphorylation , and AKT mediated [Foxo-1] phosphorylation and nuclear exclusion . Positive_regulation FOXO1 TCF7L2 24463962 2918328 In cultured HepG2 cells , did not *regulate* HNF4? and [FOXO1] transcription , but did affect HNF4a protein expression . Positive_regulation FOXO1 TGFB1 18959820 1982899 *caused* a time dependent activation of FoxO3a and a subsequent increase in [FoxO] response-element containing luciferase reporter activity , which was Akt-sensitive . Positive_regulation FOXO1 THBS1 23677673 2838403 [FoxO1] overexpression *induced* production , and a direct interaction of endogenous FoxO1 with the THBS1 promoter was detectable in primary endothelial cells . Positive_regulation FOXO1 TIE1 19615361 2124103 Consistent with this , we found that phosphorylation of [FoxO] *mediated* by activation was attenuated by lipid raft disruption . Positive_regulation FOXO1 TNF 15961397 1440766 Under in vitro conditions , platelet derived growth factor (PDGF)-BB , , and insulin-like growth factor 1 *stimulated* phosphorylation of [FoxO] in human coronary artery smooth muscle cells via MEK1/2 and/or phosphatidylinositol 3-kinase dependent signaling pathways . Positive_regulation FOXO1 TNF 15961397 1440786 PDGF-BB , , and insulin-like growth factor 1 treatment *resulted* in the nuclear exclusion of [FoxO] , whereas PDGF-BB alone down-regulated the FoxO target gene , p27 ( kip1 ) , and enhanced cell survival and progression through the cell cycle . Positive_regulation FOXO1 TNF 17599731 1774564 Immunoblotting was used to assess the interleukin-1beta (IL-1beta)- and *induced* phosphorylation of [FoxO1] and FoxO4 in cultured fibroblast-like synoviocytes ( FLS ) and macrophages . Positive_regulation FOXO1 TNF 19902175 2197528 In vitro , *induced* gene sets through [FOXO1] that regulate a number of pathways that could influence inflammation and apoptosis . Positive_regulation FOXO1 TNF 20300563 2230421 The results demonstrate pathways through which two different mediators , and an advanced glycation endproduct , can *induce* pericyte apoptosis through activation of the transcription factor [FOXO1] . Positive_regulation FOXO1 TNF 21075101 2371467 significantly *induced* the expression of [FoxO1] in asymptomatic plaque SMCs in a dose- and time dependent manner via JNK signaling pathway . Positive_regulation FOXO1 TNF 21075101 2371468 also *induced* phosphorylation of [FoxO1] , resulting in its cytoplasmic translocation/nuclear exclusion of transcription factors . Positive_regulation FOXO1 TNF 23153974 2699944 Since , is *involved* in activation of transcription factor [FOXO1] along with oxidative stress mediated by neutrophils . Positive_regulation FOXO1 TNFSF10 19470406 2097494 Collectively , our data suggest that sequential *activation* of [FoxO] proteins under conditions of suppressed PI3K/Akt signaling by can down-regulate c-FLIP ( L/S ) , consequently promoting TRAIL induced apoptosis in LX-2 cells . Positive_regulation FOXO1 TNFSF10 23630076 2779093 To gain insight into how FOXOs select specific genes for regulation , we performed a screen for genes that modify [FOXO] *activation* of , a death receptor ligand capable of inducing extrinsic apoptosis . Positive_regulation FOXO1 TRIB3 24212932 2864976 Collectively , these findings support a mechanism in which NGF deprivation , Akt dephosphorylation/inactivation , [FoxO] dephosphorylation/activation and *induction* are linked in a self amplifying feed-forward loop that culminates in neuron death . Positive_regulation FOXO1 TXNIP 24112473 2867828 Activation of the [FOXO] pathway and *induction* were examined by Western blotting , fluorescence microscopy , Chromatin immunoprecipitation ( ChIP ) assay , and reporter gene assay . Positive_regulation FOXO1 UCP1 20195385 2180905 Increased activity in IPCs results in decreased steady state Ca ( 2+ ) levels in IPCs as well as decreased PI3K activity and *increased* [FoxO] nuclear localization in periphery . Positive_regulation FOXO1 USP7 16964248 1627731 However , does negatively *regulate* [FOXO] transcriptional activity towards endogenous promoters . Positive_regulation FOXO1 VHLL 16781758 1599367 induced PI3-kinase activity *resulted* in efficient downstream signaling to Akt and consequent phosphorylation of [FKHR] and GSK3beta . Positive_regulation FOXO1 WNT1 20966918 2338371 inhibition may also *result* in a sustained activation of [FoxO] proteins with induction of apoptosis and neuronal loss , thereby completing a vicious circle from oxidative stress , InsRes and hyperglycaemia back to the formation of ROS and consecutive neurodegeneration . Positive_regulation FOXO1 WNT11 20966918 2338372 inhibition may also *result* in a sustained activation of [FoxO] proteins with induction of apoptosis and neuronal loss , thereby completing a vicious circle from oxidative stress , InsRes and hyperglycaemia back to the formation of ROS and consecutive neurodegeneration . Positive_regulation FOXO1 WNT16 20966918 2338377 inhibition may also *result* in a sustained activation of [FoxO] proteins with induction of apoptosis and neuronal loss , thereby completing a vicious circle from oxidative stress , InsRes and hyperglycaemia back to the formation of ROS and consecutive neurodegeneration . Positive_regulation FOXO1 WNT2 20966918 2338373 inhibition may also *result* in a sustained activation of [FoxO] proteins with induction of apoptosis and neuronal loss , thereby completing a vicious circle from oxidative stress , InsRes and hyperglycaemia back to the formation of ROS and consecutive neurodegeneration . Positive_regulation FOXO1 WNT3 20966918 2338374 inhibition may also *result* in a sustained activation of [FoxO] proteins with induction of apoptosis and neuronal loss , thereby completing a vicious circle from oxidative stress , InsRes and hyperglycaemia back to the formation of ROS and consecutive neurodegeneration . Positive_regulation FOXO1 WNT4 20966918 2338375 inhibition may also *result* in a sustained activation of [FoxO] proteins with induction of apoptosis and neuronal loss , thereby completing a vicious circle from oxidative stress , InsRes and hyperglycaemia back to the formation of ROS and consecutive neurodegeneration . Positive_regulation FOXO1 WNT6 20966918 2338376 inhibition may also *result* in a sustained activation of [FoxO] proteins with induction of apoptosis and neuronal loss , thereby completing a vicious circle from oxidative stress , InsRes and hyperglycaemia back to the formation of ROS and consecutive neurodegeneration . Positive_regulation FOXO1 XBP1 23277279 2758085 Thus , our findings link the dynamic process of autophagy to *induced* [FoxO1] degradation . Positive_regulation FOXO1 XBP1 23426330 2776129 Thus , our findings support the hypothesis that the turnover of [FOXO1] *induced* by MAPK1/3 and is a critical factor regulating the autophagic process . Positive_regulation FOXO1B FOXO1 9479491 487199 While and FKHRL1 are expressed in every human adult tissue examined , [FKHRP1] mRNA expression could not be *detected* , and FKHRL1P1 expression was present only at low levels . Positive_regulation FOXO3 EPHB2 15930121 1433870 Furthermore , in response to H2O2 , inhibition of activation *repressed* p66shcA dependent phosphorylation of [FOXO3a] and the down-regulation of its target gene p27kip1 . Positive_regulation FOXO3 FBXO32 16051886 1447805 Skeletal muscle atrophy developed in wild-type mice 12 weeks following myocardial infarction accompanied by an increase in total protein ubiquitination and enhanced proteasome activity , *activation* of [Foxo] transcription factors , and robust induction of the ubiquitin-protein ligase . Positive_regulation FOXO3 FBXO32 22590725 2598971 Aßi reduces levels of p-Akt and downstream p-Foxo3A , resulting in [Foxo3A] translocation and *induction* . Positive_regulation FOXO3 FOXO1 22931788 2701587 In this study , we showed that [FOXO3] induced a transcription dependent autophagy , and was *required* for this process . Positive_regulation FOXO3 IFI27 18363870 1951241 Additionally we revealed that activation of [Foxo3a] could *induce* the accumulation of ( kip1 ) at protein levels when cell cycle was arrested . Positive_regulation FOXO3 PGC 22076434 2599447 Interestingly , administering fenofibrate or tempol to the HFD induced SHRs reversed all of the renal phenotypes by increasing the PPARa expression with concomitant inactivation of the PI3K-Akt pathway , dephosphorylation of [FoxO3a] and *activation* of signaling , and this all resulted in ameliorating the oxidative stress and apoptotic cell death . Positive_regulation FOXO3 SLC38A3 15351698 1292596 also *induced* [FOXO3] phosphorylation assessed by Western blots with anti-phospho-FOXO3 antibodies , and BAPTA-AM inhibited this effect . Positive_regulation FOXO3 STK39 21212262 2391973 The MST1 is a that is activated upon apoptotic stimulation , which in turn *activates* its downstream targets , JNK/p38 , histone H2B and [FOXO] . Positive_regulation FOXO3 TNF 15961397 1440769 Under in vitro conditions , platelet derived growth factor (PDGF)-BB , , and insulin-like growth factor 1 *stimulated* phosphorylation of [FoxO] in human coronary artery smooth muscle cells via MEK1/2 and/or phosphatidylinositol 3-kinase dependent signaling pathways . Positive_regulation FOXO3 TNF 15961397 1440788 PDGF-BB , , and insulin-like growth factor 1 treatment *resulted* in the nuclear exclusion of [FoxO] , whereas PDGF-BB alone down-regulated the FoxO target gene , p27 ( kip1 ) , and enhanced cell survival and progression through the cell cycle . Positive_regulation FOXO3 TNF 19636295 2124545 *induces* the translocation of nuclear [FOXO3] into the cytosol where it undergoes proteasomal degradation in human intestinal HT-29 cells . Positive_regulation FOXO3 TNF 19636295 2124546 Proximally , the PI3K and IKK pathways mediate *induced* [FOXO3] phosphorylation . Positive_regulation FOXO3 TNF 23611379 2774613 We assessed *stimulated* expression of Cyr61 and phosphorylated inactive [FoxO3a] ( p-FoxO3a ) in MC3T3-E1 murine osteoblasts by Western analysis . Positive_regulation FOXO3 TNF 23710745 2792799 also significantly *activated* the phosphorylation of PTEN , AKT and [FOXO3a] ( P < 0.05 ) . Positive_regulation FOXO3 TNFSF10 19470406 2097495 Collectively , our data suggest that sequential *activation* of [FoxO] proteins under conditions of suppressed PI3K/Akt signaling by can down-regulate c-FLIP ( L/S ) , consequently promoting TRAIL induced apoptosis in LX-2 cells . Positive_regulation FOXO3 TNFSF10 20215638 2249247 In NB4 derived ATRA-resistant NB4/RA cells , neither [FOXO3A] nuclear localization nor subsequent *induction* was observed after ATRA treatment . Positive_regulation FOXO3 TNFSF10 23630076 2779094 To gain insight into how FOXOs select specific genes for regulation , we performed a screen for genes that modify [FOXO] *activation* of , a death receptor ligand capable of inducing extrinsic apoptosis . Positive_regulation FOXO4 EPHB2 21567078 2441235 When we examined whether HBX bypasses JNK signaling that targets Foxo4 , we found that the activity of JNK but not of is *required* for the up-regulation of [Foxo4] even in the presence of HBX . Positive_regulation FOXO4 FBXO32 16051886 1447806 Skeletal muscle atrophy developed in wild-type mice 12 weeks following myocardial infarction accompanied by an increase in total protein ubiquitination and enhanced proteasome activity , *activation* of [Foxo] transcription factors , and robust induction of the ubiquitin-protein ligase . Positive_regulation FOXO4 STK39 21212262 2392003 The MST1 is a that is activated upon apoptotic stimulation , which in turn *activates* its downstream targets , JNK/p38 , histone H2B and [FOXO] . Positive_regulation FOXO4 TNF 15961397 1440772 Under in vitro conditions , platelet derived growth factor (PDGF)-BB , , and insulin-like growth factor 1 *stimulated* phosphorylation of [FoxO] in human coronary artery smooth muscle cells via MEK1/2 and/or phosphatidylinositol 3-kinase dependent signaling pathways . Positive_regulation FOXO4 TNF 15961397 1440790 PDGF-BB , , and insulin-like growth factor 1 treatment *resulted* in the nuclear exclusion of [FoxO] , whereas PDGF-BB alone down-regulated the FoxO target gene , p27 ( kip1 ) , and enhanced cell survival and progression through the cell cycle . Positive_regulation FOXO4 TNF 17242183 1710042 signaling *upregulates* nuclear [FoxO4] . Positive_regulation FOXO4 TNF 17599731 1774565 Immunoblotting was used to assess the interleukin-1beta (IL-1beta)- and *induced* phosphorylation of FoxO1 and [FoxO4] in cultured fibroblast-like synoviocytes ( FLS ) and macrophages . Positive_regulation FOXO4 TNF 18701653 1974123 Instead , *increases* nuclear [Foxo4] protein ( +55 % ) . Positive_regulation FOXO4 TNFSF10 19470406 2097496 Collectively , our data suggest that sequential *activation* of [FoxO] proteins under conditions of suppressed PI3K/Akt signaling by can down-regulate c-FLIP ( L/S ) , consequently promoting TRAIL induced apoptosis in LX-2 cells . Positive_regulation FOXO4 TNFSF10 23630076 2779095 To gain insight into how FOXOs select specific genes for regulation , we performed a screen for genes that modify [FOXO] *activation* of , a death receptor ligand capable of inducing extrinsic apoptosis . Positive_regulation FOXO6 FBXO32 16051886 1447803 Skeletal muscle atrophy developed in wild-type mice 12 weeks following myocardial infarction accompanied by an increase in total protein ubiquitination and enhanced proteasome activity , *activation* of [Foxo] transcription factors , and robust induction of the ubiquitin-protein ligase . Positive_regulation FOXO6 STK39 21212262 2391943 The MST1 is a that is activated upon apoptotic stimulation , which in turn *activates* its downstream targets , JNK/p38 , histone H2B and [FOXO] . Positive_regulation FOXO6 TNF 15961397 1440763 Under in vitro conditions , platelet derived growth factor (PDGF)-BB , , and insulin-like growth factor 1 *stimulated* phosphorylation of [FoxO] in human coronary artery smooth muscle cells via MEK1/2 and/or phosphatidylinositol 3-kinase dependent signaling pathways . Positive_regulation FOXO6 TNF 15961397 1440784 PDGF-BB , , and insulin-like growth factor 1 treatment *resulted* in the nuclear exclusion of [FoxO] , whereas PDGF-BB alone down-regulated the FoxO target gene , p27 ( kip1 ) , and enhanced cell survival and progression through the cell cycle . Positive_regulation FOXO6 TNFSF10 19470406 2097493 Collectively , our data suggest that sequential *activation* of [FoxO] proteins under conditions of suppressed PI3K/Akt signaling by can down-regulate c-FLIP ( L/S ) , consequently promoting TRAIL induced apoptosis in LX-2 cells . Positive_regulation FOXO6 TNFSF10 23630076 2779092 To gain insight into how FOXOs select specific genes for regulation , we performed a screen for genes that modify [FOXO] *activation* of , a death receptor ligand capable of inducing extrinsic apoptosis . Positive_regulation FOXP3 FOXO1 24048895 2851755 Furthermore , PrxII deficiency stabilized FoxO1 expression by reducing mouse double minute 2 homolog expression and subsequently activated *mediated* [Foxp3] gene transcription . Positive_regulation FOXP3 HES2 20876311 2337300 [Foxp3] *induction* by was lost in dominant negative TGF-ßRII cells and was abolished by the TGF-ß signaling inhibitor SB431542 . Positive_regulation FOXP3 IFI27 20200542 2265353 However , silencing of Foxp3 reduced expression of [Foxp3] , and PD1-all of which are *involved* in the suppressive capacity of CD8 ( + ) Treg in this model . Positive_regulation FOXP3 RORC 20427770 2262565 Although overexpression of in naive T cells *reduces* levels of [FOXP3] , small interfering RNA mediated knockdown of RORC2 enhances its expression . Positive_regulation FOXP3 SRGN 16551363 1542058 *induced* IL-10 production and induction of [Foxp3] were higher in CBMC without , than with maternal atopy ( p = 0.04 , p = 0.049 ) . Positive_regulation FOXP3 SRGN 18925880 1977512 T regulatory and Th17 cells were less expressed in cord than in adult blood ( *induced* [Foxp3] , P = 0.001 , LpA induced CD4 ( + ) CD25 ( + ) high , P = 0.02 ; Positive_regulation FOXP3 TNF 20181891 2229107 In contrast , *had* only a minimal effect on the Treg 's core transcriptional signature or on the intracellular levels of the [FOXP3] protein in Tregs . Positive_regulation FOXP3 TNF 21491419 2444161 Our previous studies demonstrated that *up-regulated* [FoxP3] expression and activated and expanded CD4+ FoxP3+ regulatory T cells ( Tregs ) via TNFR2 . Positive_regulation FOXP3 TNF 21641234 2459347 It indicates that *reduces* the number and frequency of regulatory CD4 ( + ) [Foxp3] ( + ) T cells in children with diabetes type 1 and that in vitro treatment with anti-TNF antibody seems to rescue this cell subset from its defective effects . Positive_regulation FOXP3 TNF 23277487 2732668 Importantly , partially abrogated this effect of TCR stimulation and *stabilized* [Foxp3] expression . Positive_regulation FOXP3 TNF 24383743 2932652 However , we and others showed that interaction was *critical* for the activation and expansion of functional CD4 ( + ) [Foxp3] ( + ) regulatory T ( Treg ) cells . Positive_regulation FOXQ1 NACC1 24200849 2891706 Ectopic expression of in NACC1 null cells *induced* [FOXQ1] expression . Positive_regulation FOXQ1 NACC1 24200849 2891708 We further demonstrate that is *essential* and sufficient for activation of [FOXQ1] transcription and that the role of NAC1 in cell motility is mediated , at least in part , by FOXQ1 . Positive_regulation FOXQ1 PTPRO 22126837 2542250 The findings should be replicated in independent samples , but indicate a *role* of in learning and memory , WDR72 with executive functioning , and an interaction between [FOXQ1] and SUMO1P1 for psychomotor speed . Positive_regulation FOXQ1 SLC22A3 23403865 2748699 In conclusion that FOXQ1 may be a novel *inducing* transcription factor through controlling the expression of E-cadherin and aggressiveness of cancer cells and targeting the transcription factor [FOXQ1] could hence serve as a novel therapeutic strategy for cancer patients . Positive_regulation FOXQ1 SLC22A3 24005989 2916087 [FoxQ1] *induced* through the transactivation of ZEB2 expression by directly binding to the ZEB2 promoter . Positive_regulation FPR1 TNF 20889801 2395369 The expression of [FPR] was increased in *response* to , LPS , scratch injury , and mitochondrial antigen treatment . Positive_regulation FPR1 TNF 2155274 129376 One basis for this phenomenon appeared to be *mediated* [FMLP receptor] mobilization . Positive_regulation FPR2 IL1B 15271420 1276562 A TP agonist , U46619 showed a down-regulation of [LXA4 receptor] *induced* by in RAW246.7 cells . Positive_regulation FPR2 TNF 12270697 990951 *Up-regulation* of [FPR2] , a chemotactic receptor for amyloid beta 1-42 ( A beta 42 ) , in murine microglial cells by . Positive_regulation FPR2 TNF 16237106 1470776 We have previously shown that *up-regulated* the expression of [formyl peptide receptor 2] ( mFPR2 ) in mouse microglial cells , resulting in increased chemotactic responses of such cells to mFPR2 agonists , including amyloid beta1-42 ( Abeta42 ) , a critical pathogenic agent in Alzheimer 's disease . Positive_regulation FRMD6 ARSG 15640392 1388028 Aerobic exercise training significantly ( P < or = 0.05 ) *increased* peak aerobic capacity in [MS-Ex [1.86] ( SD 0.75 ) vs. 2.10 ( SD 0.67 ) l/min ] with no changes in , SR , and SGO . Positive_regulation FRS2 MAP2K6 11278583 802657 The [SNT1] ( IRS ) CX-mediated response was *dependent* on endogenous Ras , , and Shp2 activities . Positive_regulation FSCN1 EPHB2 15537893 1336630 In the injured L5 DRG , the L5 [SNL] *induced* the activation of , p38 , and JNK in different populations of DRG neurons . Positive_regulation FSHB EPHB2 11399487 824213 is *involved* in GnRH elevation of GPalpha and LHbeta , but not in [FSHbeta] genes transcription . Positive_regulation FSHB EPHB2 14736735 1226073 Thus , PKC , , JNK , p38 , and c-Src , but not Ca ( 2+ ) , are *involved* in GnRH induction of the ovine [FSHbeta] gene . Positive_regulation FSHB FOXO1 24065703 2857779 In summary , our data demonstrate that can negatively *regulate* [Fshb] transcription and suggest that FOXO1 may relay metabolic hormonal signals to modulate gonadotropin production . Positive_regulation FSHB TF 8706718 373462 The transcription of the gene is *induced* by [follitropin] via cAMP in rat Sertoli cells . Positive_regulation FSHMD1A PECAM1 16166207 1499840 These results suggest that is *necessary* for normal [FMD] in the mouse coronary circulation . Positive_regulation FSHR TGM2 1359984 204498 Stabilization of [follicle stimulating hormone-receptor] complexes may *involve* calcium dependent activation . Positive_regulation FST CCND1 18804092 1976229 [Follistatin] *induced* and the trefoil factors TFF1 and TFF2 in a gastric cancer cell line . Positive_regulation FST EPHB2 21828177 2485420 A p38 MAPK inhibitor , SB202190 , a kinase inhibitor , U0126 , and an nuclear factor ?B pathway inhibitor , SC-514 , significantly *suppressed* the IL-1ß stimulated INHBA and [FST] mRNA expression . Positive_regulation FST IL1B 12538636 1050207 ( 0.005-5 nM ) *stimulated* the secretion of [follistatin] and increased mRNA expression . Positive_regulation FST IL1B 15941932 1415653 [Follistatin] secretion was significantly increased in the *presence* of at 6-8 weeks gestation . Positive_regulation FST IL1B 9645713 514900 *regulates* pituitary [follistatin] and inhibin/activin betaB mRNA levels and attenuates FSH secretion in response to activin-A . Positive_regulation FST IL1B 9645713 514902 RNase protection analysis indicated that ( 0.005 to 5 nM ) *stimulated* [follistatin] and inhibin/activin betaB mRNA accumulation in a time dependent manner . Positive_regulation FST MAP2K6 19446581 2096754 TRH induced [follistatin] expression was significantly abrogated in the *presence* of inhibitor , U0126 . Positive_regulation FST TNF 23171678 2775235 [Follistatin] is *induced* by IL-1ß and in stromal cells from endometrioma . Positive_regulation FSTL1 TNF 16783405 1599406 In contrast , S. aureus ( TLR2/TLR1/TLR6 ) or Pam ( 3 ) CSK4 ( TLR2/TLR1 ) , or [FSL-1] and LTA ( TLR2/TLR6 ) *induced* without an effect on NO. 3 . Positive_regulation FSTL1 TNF 20506332 2301237 [FSTL-1] could be *induced* in osteoblasts , adipocytes , and human fibroblast-like synoviocytes by TGFbeta , IL-1beta , , and IL-6 . Positive_regulation FTH1 TNF 24066693 2867103 In addition , *up-regulated* [Ferritin heavy chain (FHC)] transiently by NF-?B activation and FHC levels were correlated with the TNF-a induced protection against serum starvation mediated apoptosis of hepatocellular carcinoma cells . Positive_regulation FTH1 TNF 7797515 314002 In fibroblasts and other cells , the cytokine specifically *induces* synthesis of the [ferritin H subunit] . Positive_regulation FTH1 TNF 8324080 223261 did not *induce* the synthesis of [ferritin heavy chain] in L929 cells . Positive_regulation FUBP1 FOLR1 11747307 897994 The T311M A [ bond ] A interface mutant has a decreased affinity for PEP and [FBP] , and is *dependent* on for activity . Positive_regulation FURIN EPHB2 20634490 2334910 The data indicate that transferrin receptor 2 and HFE are involved in holotransferrin dependent signaling for the regulation of [furin] which *involved* phosphorylation . Positive_regulation FURIN F2R 24015257 2837205 Despite no apparent direct effect on virus replication during in vitro experiments , an important *role* for in the regulation of [furin] expression in the lungs was shown for the first time . Positive_regulation FUT1 CCND1 17559421 1762835 [HSC-T6-Id2-GFP] *increased* cell proliferation with expression . Positive_regulation FUT1 CTGF 12065687 954664 In conclusion , this study extends the *role* of in [HSC] activation and suggests that CTGF up-regulation might be a central pathway during HSC activation . Positive_regulation FUT1 EPHB2 10347117 616718 Insulin and IGF-1 *induced* 70-kd S6 kinase phosphorylation in [HSC] , whereas IGF-1 only induced phosphorylation . Positive_regulation FUT1 EPHB2 10498647 647610 In this study , we evaluated the *role* of activation in cultured [HSC] stimulated with platelet derived growth factor ( PDGF ) and after induction of liver injury in vivo . Positive_regulation FUT1 EPHB2 10498647 647617 In [HSC] isolated from CCl ( 4 ) -treated rats , activity *increased* as early as 6 hours following liver damage , and declined thereafter . Positive_regulation FUT1 HBEGF 22330337 2586588 Both endogenous and exogenous HB-EGF inhibited [HSC] activation in primary culture , and *enhanced* HSC migration . Positive_regulation FUT1 IL1B 19567026 2104389 At the concentration of 0.0625 to 0.25 mmol/L , Danshensu significantly repressed the proliferation of [HSC] *induced* by ( P < 0.05 ) . Positive_regulation FUT1 MMP28 16958682 1611173 In vitro experiments also demonstrated the *role* of in activation of [HSC] cultured in 3-D ECM . Positive_regulation FUT1 MMP7 16958682 1611188 In vitro experiments also demonstrated the *role* of in activation of [HSC] cultured in 3-D ECM . Positive_regulation FUT1 SYNM 15099470 1239040 By morphology and RT-PCR , we study the changes of expression of PPARgamma in culture activated HSC or in vivo activated [HSC] *induced* by . Positive_regulation FUT1 TNF 12585120 895563 Adhesion molecular VCAM-1 and ICAM-1 protein and mRNA ( rather than ICAM-1 ) expression in [HSC] *induced* by ( 50 U.mL-1 ) were inhibited significantly by hydrocortisone at 1 x 10 ( -6 ) -10 ( -5 ) mol . Positive_regulation FUT1 TNF 12585121 895567 To study the effects of isorhapotigenin ( Iso ) on interleukin-8 (IL-8) production and mRNA expression in normal [human synovial cells (HSC)] *induced* with . Positive_regulation FUT1 TNF 23553591 2843598 Notably , IL-1 and did not *promote* [HSC] activation but promoted survival of activated HSCs in vitro and in vivo and thereby increased liver fibrosis , as demonstrated by neutralization in coculture experiments and genetic ablation of IL-1 and TNF receptor in vivo . Positive_regulation FUT1 TNF 23839903 2809045 JTE-013 or S1PR2-siRNA attenuated the effect of HPPCn on [HSC] activation *induced* by . Positive_regulation FUT4 AKT1 23887626 2821551 Moreover , [FUT4] *induced* activation of phosphatidylinositol 3-kinase <(PI3K)/Akt> , and inactivation of GSK3ß and nuclear translocation of NF-?B , resulting in increased Snail and MMP-9 expression and greater cell motility . Positive_regulation FUT4 AKT2 23887626 2821552 Moreover , [FUT4] *induced* activation of phosphatidylinositol 3-kinase <(PI3K)/Akt> , and inactivation of GSK3ß and nuclear translocation of NF-?B , resulting in increased Snail and MMP-9 expression and greater cell motility . Positive_regulation FUT4 AKT3 23887626 2821553 Moreover , [FUT4] *induced* activation of phosphatidylinositol 3-kinase <(PI3K)/Akt> , and inactivation of GSK3ß and nuclear translocation of NF-?B , resulting in increased Snail and MMP-9 expression and greater cell motility . Positive_regulation FUT4 FUT1 15649251 1363753 Transfection of the mouse and Fut2 , and human FUT1 genes into human ovarian carcinoma derived RMG-1 cells *resulted* in 20-30-fold increases in cellular [alpha1,2-fucosyltransferase] activity , and in alteration of the glycolipid composition , including not only fucosylated products , but also precursor glycolipids . Positive_regulation FUT4 FUT10 23986452 2851042 Our data suggest that is *involved* in a unique [a1,3-fucosyltransferase] activity with stringent substrate specificity , and that this activity is required to maintain stem cells in an undifferentiated state . Positive_regulation FUT4 FUT2 15649251 1363754 Transfection of the mouse Fut1 and , and human FUT1 genes into human ovarian carcinoma derived RMG-1 cells *resulted* in 20-30-fold increases in cellular [alpha1,2-fucosyltransferase] activity , and in alteration of the glycolipid composition , including not only fucosylated products , but also precursor glycolipids . Positive_regulation FUT4 FUT9 11278338 810941 These findings suggest that the expression of [CD15] in mature granulocytes is *directed* by , whereas it is determined in promyelocytes and monocytes by FUT4 . Positive_regulation FUT4 HNF1A 21203500 2359142 We show that and its downstream target HNF4a *regulate* the expression of key [fucosyltransferase] and fucose biosynthesis genes . Positive_regulation FUT4 HNF4A 21203500 2359143 We show that HNF1a and its downstream target *regulate* the expression of key [fucosyltransferase] and fucose biosynthesis genes . Positive_regulation FUT4 HSF1 23959823 2885298 and Sp1 *regulate* [FUT4] gene expression and cell proliferation in breast cancer cells . Positive_regulation FUT4 IL1A 21365246 2411508 *induced* significant increases in the mRNA levels of FUT1 , FUT2 and [FUT4] , and decreases of FUT3 and FUT5 . Positive_regulation FUT4 IL1A 21365246 2411510 The *activation* of FUT1 , FUT2 and [FUT4] by is through the NF-?B pathway and the down-regulation of FUT3 and FUT5 by IL-6 is through the gp130/STAT-3 pathway , since they are inhibited specifically by panepoxydone and AG490 , respectively . Positive_regulation FUT4 IL1B 11698472 878062 also *induced* O ( 2 ) ( - ) release and up-regulation of CD11b and [CD15] , and both responses were inhibited by SB203580 ( p38 MAPK inhibitor ) , suggesting that p38 MAPK activation mediates IL-1beta induced O ( 2 ) ( - ) release and up-regulation of CD11b and CD15 . Positive_regulation FUT4 IL1B 11698472 878106 These findings suggest that 1 ) in human neutrophils the MKK3/6-p38 MAPK cascade is selectively activated by and activation of this cascade *mediates* IL-1beta induced O ( 2 ) ( - ) release and up-regulation of CD11b and [CD15] , and 2 ) the IL-1R-p38 MAPK pathway and the G-CSF receptor-ERK pathway work independently for activation of neutrophils . Positive_regulation FUT4 IL6 15046557 1224951 Conversely , TNF-alpha , , and IL-8 *increased* reactive oxygen species production and the expression of CD11b and [CD15] on both neutrophils and monocytes and decreased the expression of CD62L . Positive_regulation FUT4 IL6 16934790 1627290 We found that *promoted* the generation of [CD15] ( + ) granulocytic and CD14 ( + ) monocytic cells and suppressed that of CD14 ( - ) CD1a ( + ) dendritic cells from CD36 ( - ) CD15 ( - ) CD14 ( - ) CD1a ( - ) IL-6R ( + ) myeloid progenitors . Positive_regulation FUT4 IL8 15046557 1224952 Conversely , TNF-alpha , IL-6 , and *increased* reactive oxygen species production and the expression of CD11b and [CD15] on both neutrophils and monocytes and decreased the expression of CD62L . Positive_regulation FUT4 INS 1731959 181412 Thyroxine and , injected into suckling rats , did not *induce* significant modifications of the [fucosyl-transferase] activity , under the conditions used , whereas this enzyme activity was highly enhanced after administration of glucocorticoids ( cortisone and hydrocortisone ) . Positive_regulation FUT4 INS 9815021 546473 treatment of young suckling rats *induced* a precocious increase in [fucosyltransferase] activity and in the biosynthesis of its substrate ( GDP-fucose ) , but the sensitivity to insulin disappeared after weaning . Positive_regulation FUT4 KCNH4 11006292 752568 Human [alpha (1,3)-fucosyltransferase IV] ( FUTIV ) gene expression is *regulated* by in the U937 cell line . Positive_regulation FUT4 MAPK1 11698472 878063 IL-1beta also induced O ( 2 ) ( - ) release and up-regulation of CD11b and CD15 , and both responses were inhibited by SB203580 ( p38 MAPK inhibitor ) , suggesting that p38 activation *mediates* IL-1beta induced O ( 2 ) ( - ) release and up-regulation of CD11b and [CD15] . Positive_regulation FUT4 MAPK10 11698472 878064 IL-1beta also induced O ( 2 ) ( - ) release and up-regulation of CD11b and CD15 , and both responses were inhibited by SB203580 ( p38 MAPK inhibitor ) , suggesting that p38 activation *mediates* IL-1beta induced O ( 2 ) ( - ) release and up-regulation of CD11b and [CD15] . Positive_regulation FUT4 MAPK11 11698472 878065 IL-1beta also induced O ( 2 ) ( - ) release and up-regulation of CD11b and CD15 , and both responses were inhibited by SB203580 ( p38 MAPK inhibitor ) , suggesting that p38 activation *mediates* IL-1beta induced O ( 2 ) ( - ) release and up-regulation of CD11b and [CD15] . Positive_regulation FUT4 MAPK12 11698472 878066 IL-1beta also induced O ( 2 ) ( - ) release and up-regulation of CD11b and CD15 , and both responses were inhibited by SB203580 ( p38 MAPK inhibitor ) , suggesting that p38 activation *mediates* IL-1beta induced O ( 2 ) ( - ) release and up-regulation of CD11b and [CD15] . Positive_regulation FUT4 MAPK13 11698472 878067 IL-1beta also induced O ( 2 ) ( - ) release and up-regulation of CD11b and CD15 , and both responses were inhibited by SB203580 ( p38 MAPK inhibitor ) , suggesting that p38 activation *mediates* IL-1beta induced O ( 2 ) ( - ) release and up-regulation of CD11b and [CD15] . Positive_regulation FUT4 MAPK14 11698472 878068 IL-1beta also induced O ( 2 ) ( - ) release and up-regulation of CD11b and CD15 , and both responses were inhibited by SB203580 ( p38 MAPK inhibitor ) , suggesting that p38 activation *mediates* IL-1beta induced O ( 2 ) ( - ) release and up-regulation of CD11b and [CD15] . Positive_regulation FUT4 MAPK15 11698472 878061 IL-1beta also induced O ( 2 ) ( - ) release and up-regulation of CD11b and CD15 , and both responses were inhibited by SB203580 ( p38 MAPK inhibitor ) , suggesting that p38 activation *mediates* IL-1beta induced O ( 2 ) ( - ) release and up-regulation of CD11b and [CD15] . Positive_regulation FUT4 MAPK3 11698472 878069 IL-1beta also induced O ( 2 ) ( - ) release and up-regulation of CD11b and CD15 , and both responses were inhibited by SB203580 ( p38 MAPK inhibitor ) , suggesting that p38 activation *mediates* IL-1beta induced O ( 2 ) ( - ) release and up-regulation of CD11b and [CD15] . Positive_regulation FUT4 MAPK4 11698472 878070 IL-1beta also induced O ( 2 ) ( - ) release and up-regulation of CD11b and CD15 , and both responses were inhibited by SB203580 ( p38 MAPK inhibitor ) , suggesting that p38 activation *mediates* IL-1beta induced O ( 2 ) ( - ) release and up-regulation of CD11b and [CD15] . Positive_regulation FUT4 MAPK6 11698472 878071 IL-1beta also induced O ( 2 ) ( - ) release and up-regulation of CD11b and CD15 , and both responses were inhibited by SB203580 ( p38 MAPK inhibitor ) , suggesting that p38 activation *mediates* IL-1beta induced O ( 2 ) ( - ) release and up-regulation of CD11b and [CD15] . Positive_regulation FUT4 MAPK7 11698472 878072 IL-1beta also induced O ( 2 ) ( - ) release and up-regulation of CD11b and CD15 , and both responses were inhibited by SB203580 ( p38 MAPK inhibitor ) , suggesting that p38 activation *mediates* IL-1beta induced O ( 2 ) ( - ) release and up-regulation of CD11b and [CD15] . Positive_regulation FUT4 MAPK8 11698472 878073 IL-1beta also induced O ( 2 ) ( - ) release and up-regulation of CD11b and CD15 , and both responses were inhibited by SB203580 ( p38 MAPK inhibitor ) , suggesting that p38 activation *mediates* IL-1beta induced O ( 2 ) ( - ) release and up-regulation of CD11b and [CD15] . Positive_regulation FUT4 MAPK9 11698472 878074 IL-1beta also induced O ( 2 ) ( - ) release and up-regulation of CD11b and CD15 , and both responses were inhibited by SB203580 ( p38 MAPK inhibitor ) , suggesting that p38 activation *mediates* IL-1beta induced O ( 2 ) ( - ) release and up-regulation of CD11b and [CD15] . Positive_regulation FUT4 NEU1 18953356 1989281 [CD15] expression in human myeloid cell differentiation is *regulated* by activity . Positive_regulation FUT4 NEU1 18953356 1989289 Flow cytometric analysis of differentiating cells together with biochemical studies using inhibitors of glycan synthesis and of sialidases showed that increased [CD15] expression is not due to de novo biosynthesis of CD15 , but *results* predominantly from induction of alpha ( 2-3 ) <-sialidase> activity , which yields CD15 from cell-surface sialyl-CD15 ( also known as sialyl-Lewis x , sLe ( x ) or CD15s ) . Positive_regulation FUT4 NEU2 18953356 1989282 [CD15] expression in human myeloid cell differentiation is *regulated* by activity . Positive_regulation FUT4 NEU2 18953356 1989290 Flow cytometric analysis of differentiating cells together with biochemical studies using inhibitors of glycan synthesis and of sialidases showed that increased [CD15] expression is not due to de novo biosynthesis of CD15 , but *results* predominantly from induction of alpha ( 2-3 ) <-sialidase> activity , which yields CD15 from cell-surface sialyl-CD15 ( also known as sialyl-Lewis x , sLe ( x ) or CD15s ) . Positive_regulation FUT4 NEU3 18953356 1989283 [CD15] expression in human myeloid cell differentiation is *regulated* by activity . Positive_regulation FUT4 NEU3 18953356 1989291 Flow cytometric analysis of differentiating cells together with biochemical studies using inhibitors of glycan synthesis and of sialidases showed that increased [CD15] expression is not due to de novo biosynthesis of CD15 , but *results* predominantly from induction of alpha ( 2-3 ) <-sialidase> activity , which yields CD15 from cell-surface sialyl-CD15 ( also known as sialyl-Lewis x , sLe ( x ) or CD15s ) . Positive_regulation FUT4 NEU4 18953356 1989280 [CD15] expression in human myeloid cell differentiation is *regulated* by activity . Positive_regulation FUT4 NEU4 18953356 1989288 Flow cytometric analysis of differentiating cells together with biochemical studies using inhibitors of glycan synthesis and of sialidases showed that increased [CD15] expression is not due to de novo biosynthesis of CD15 , but *results* predominantly from induction of alpha ( 2-3 ) <-sialidase> activity , which yields CD15 from cell-surface sialyl-CD15 ( also known as sialyl-Lewis x , sLe ( x ) or CD15s ) . Positive_regulation FUT4 PI3 23887626 2821554 Moreover , [FUT4] *induced* activation of , and inactivation of GSK3ß and nuclear translocation of NF-?B , resulting in increased Snail and MMP-9 expression and greater cell motility . Positive_regulation FUT4 POLDIP2 11698472 878060 IL-1beta also induced O ( 2 ) ( - ) release and up-regulation of CD11b and CD15 , and both responses were inhibited by SB203580 ( p38 MAPK inhibitor ) , suggesting that MAPK activation *mediates* IL-1beta induced O ( 2 ) ( - ) release and up-regulation of CD11b and [CD15] . Positive_regulation FUT4 SELE 10894166 711510 P-selectin ligands generated by FucT-VII are crucial for initial leukocyte tethering , whereas ligands that permit maximum slowing of Vroll *require* simultaneous expression of [FucT-IV] and FucT-VII . Positive_regulation FUT4 SELP 7505206 237583 Significant binding of transfected COS cells to *requires* coexpression of both the protein ligand and a [fucosyltransferase] . Positive_regulation FUT4 SP1 23959823 2885297 HSF1 and *regulate* [FUT4] gene expression and cell proliferation in breast cancer cells . Positive_regulation FUT4 TAL1 18436863 1920982 Decreased expression in CMP *resulted* in rare erythroid colonies , in a 2-3 fold reduction of GM colony number in clonogenic assays and in a 3.6-5.6 decreased production of CD14 ( + ) [CD15] ( + ) GM cells in liquid culture . Positive_regulation FUT4 TNF 15046557 1224950 Conversely , , IL-6 , and IL-8 *increased* reactive oxygen species production and the expression of CD11b and [CD15] on both neutrophils and monocytes and decreased the expression of CD62L . Positive_regulation FUT9 EPHB2 19048108 1999248 A phospholipase Cgamma (PLCgamma) inhibitor and shRNA , as well as an inhibitor , *reduced* ST6Gal1 and [FUT9] mRNA levels and inhibited effects of L1 on neurite outgrowth and cell survival . Positive_regulation FYN EDN2 9857056 555345 , a well known hypertrophic agonist , *increased* activity of c-Src , c-Yes , and [Fyn] within minutes and promoted a selective redistribution of each of these kinases within the cell . Positive_regulation FZD4 CTHRC1 18606138 1935711 Cell-surface anchored bound to Wnt proteins , Fzd proteins , and Ror2 and *enhanced* the interaction of Wnt proteins and [Fzd/Ror2] by forming the Cthrc1-Wnt-Fzd/Ror2 complex . Positive_regulation FZD4 CTNNB1 20212039 2249162 [FZD] *activation* of canonical signaling requires the adapter protein Dishevelled (Dvl) . Positive_regulation FZD4 DVL1 20212039 2249163 [FZD] activation of canonical beta-catenin signaling *requires* the adapter protein . Positive_regulation FZD4 DVL2 20212039 2249164 [FZD] activation of canonical beta-catenin signaling *requires* the adapter protein . Positive_regulation FZD4 DVL3 20212039 2249165 [FZD] activation of canonical beta-catenin signaling *requires* the adapter protein . Positive_regulation FZD4 NDP 15035989 1223841 We show here that Norrin and Fz4 function as a ligand-receptor pair based on ( 1 ) the similarity in vascular phenotypes caused by Norrin and Fz4 mutations in humans and mice , ( 2 ) the specificity and high affinity of Norrin-Fz4 binding , ( 3 ) the high efficiency with which *induces* [Fz4-] and Lrp dependent activation of the classical Wnt pathway , and ( 4 ) the signaling defects displayed by disease associated variants of Norrin and Fz4 . Positive_regulation FZD4 NDP 22103505 2509486 Finally , Tspan12 is required for blood vessel development in the eye , through regulation of *induced* [Frizzled-4] signalling , such that Tspan12 mutations can lead to human disease . Positive_regulation FZD4 NDP 24186977 2864266 Instead of inducing Fz4 dimerization , *induces* the formation of a ternary complex with [Fz4] and Lrp5/6 by binding to their respective extracellular domains . Positive_regulation FZD4 WNT1 19020754 1992172 *Activation* of signalling in acute myeloid leukemia by induction of [Frizzled-4] . Positive_regulation FZD4 WNT1 19837033 2154996 TSPAN12 regulates retinal vascular development by promoting Norrin- but not *induced* [FZD4/beta-catenin] signaling . Positive_regulation FZD4 WNT1 20713528 2312928 [FZD4] as a mediator of ERG oncogene *induced* signaling and epithelial-to-mesenchymal transition in human prostate cancer cells . Positive_regulation FZD4 WNT1 22907437 2809384 The level of the active form of Arf ( Arf-GTP ) transiently increased in the *presence* of , and this induction event was abrogated by blocking the interaction between Wnt and [Frizzled (Fzd)] . Positive_regulation FZD4 WNT1 23146885 2703964 Itch directly associates with and ubiquitinates PI4KIIa , and both proteins colocalize on endosomes containing *activated* [frizzled 4 (Fz4)] receptor . Positive_regulation FZD4 WNT11 19020754 1992173 *Activation* of signalling in acute myeloid leukemia by induction of [Frizzled-4] . Positive_regulation FZD4 WNT11 19837033 2154997 TSPAN12 regulates retinal vascular development by promoting Norrin- but not *induced* [FZD4/beta-catenin] signaling . Positive_regulation FZD4 WNT11 20713528 2312929 [FZD4] as a mediator of ERG oncogene *induced* signaling and epithelial-to-mesenchymal transition in human prostate cancer cells . Positive_regulation FZD4 WNT11 22907437 2809385 The level of the active form of Arf ( Arf-GTP ) transiently increased in the *presence* of , and this induction event was abrogated by blocking the interaction between Wnt and [Frizzled (Fzd)] . Positive_regulation FZD4 WNT11 23146885 2703965 Itch directly associates with and ubiquitinates PI4KIIa , and both proteins colocalize on endosomes containing *activated* [frizzled 4 (Fz4)] receptor . Positive_regulation FZD4 WNT16 19020754 1992178 *Activation* of signalling in acute myeloid leukemia by induction of [Frizzled-4] . Positive_regulation FZD4 WNT16 19837033 2155002 TSPAN12 regulates retinal vascular development by promoting Norrin- but not *induced* [FZD4/beta-catenin] signaling . Positive_regulation FZD4 WNT16 20713528 2312934 [FZD4] as a mediator of ERG oncogene *induced* signaling and epithelial-to-mesenchymal transition in human prostate cancer cells . Positive_regulation FZD4 WNT16 22907437 2809390 The level of the active form of Arf ( Arf-GTP ) transiently increased in the *presence* of , and this induction event was abrogated by blocking the interaction between Wnt and [Frizzled (Fzd)] . Positive_regulation FZD4 WNT16 23146885 2703970 Itch directly associates with and ubiquitinates PI4KIIa , and both proteins colocalize on endosomes containing *activated* [frizzled 4 (Fz4)] receptor . Positive_regulation FZD4 WNT2 19020754 1992174 *Activation* of signalling in acute myeloid leukemia by induction of [Frizzled-4] . Positive_regulation FZD4 WNT2 19837033 2154998 TSPAN12 regulates retinal vascular development by promoting Norrin- but not *induced* [FZD4/beta-catenin] signaling . Positive_regulation FZD4 WNT2 20713528 2312930 [FZD4] as a mediator of ERG oncogene *induced* signaling and epithelial-to-mesenchymal transition in human prostate cancer cells . Positive_regulation FZD4 WNT2 22907437 2809386 The level of the active form of Arf ( Arf-GTP ) transiently increased in the *presence* of , and this induction event was abrogated by blocking the interaction between Wnt and [Frizzled (Fzd)] . Positive_regulation FZD4 WNT2 23146885 2703966 Itch directly associates with and ubiquitinates PI4KIIa , and both proteins colocalize on endosomes containing *activated* [frizzled 4 (Fz4)] receptor . Positive_regulation FZD4 WNT3 19020754 1992175 *Activation* of signalling in acute myeloid leukemia by induction of [Frizzled-4] . Positive_regulation FZD4 WNT3 19837033 2154999 TSPAN12 regulates retinal vascular development by promoting Norrin- but not *induced* [FZD4/beta-catenin] signaling . Positive_regulation FZD4 WNT3 20713528 2312931 [FZD4] as a mediator of ERG oncogene *induced* signaling and epithelial-to-mesenchymal transition in human prostate cancer cells . Positive_regulation FZD4 WNT3 22907437 2809387 The level of the active form of Arf ( Arf-GTP ) transiently increased in the *presence* of , and this induction event was abrogated by blocking the interaction between Wnt and [Frizzled (Fzd)] . Positive_regulation FZD4 WNT3 23146885 2703967 Itch directly associates with and ubiquitinates PI4KIIa , and both proteins colocalize on endosomes containing *activated* [frizzled 4 (Fz4)] receptor . Positive_regulation FZD4 WNT4 19020754 1992176 *Activation* of signalling in acute myeloid leukemia by induction of [Frizzled-4] . Positive_regulation FZD4 WNT4 19837033 2155000 TSPAN12 regulates retinal vascular development by promoting Norrin- but not *induced* [FZD4/beta-catenin] signaling . Positive_regulation FZD4 WNT4 20713528 2312932 [FZD4] as a mediator of ERG oncogene *induced* signaling and epithelial-to-mesenchymal transition in human prostate cancer cells . Positive_regulation FZD4 WNT4 22907437 2809388 The level of the active form of Arf ( Arf-GTP ) transiently increased in the *presence* of , and this induction event was abrogated by blocking the interaction between Wnt and [Frizzled (Fzd)] . Positive_regulation FZD4 WNT4 23146885 2703968 Itch directly associates with and ubiquitinates PI4KIIa , and both proteins colocalize on endosomes containing *activated* [frizzled 4 (Fz4)] receptor . Positive_regulation FZD4 WNT6 19020754 1992177 *Activation* of signalling in acute myeloid leukemia by induction of [Frizzled-4] . Positive_regulation FZD4 WNT6 19837033 2155001 TSPAN12 regulates retinal vascular development by promoting Norrin- but not *induced* [FZD4/beta-catenin] signaling . Positive_regulation FZD4 WNT6 20713528 2312933 [FZD4] as a mediator of ERG oncogene *induced* signaling and epithelial-to-mesenchymal transition in human prostate cancer cells . Positive_regulation FZD4 WNT6 22907437 2809389 The level of the active form of Arf ( Arf-GTP ) transiently increased in the *presence* of , and this induction event was abrogated by blocking the interaction between Wnt and [Frizzled (Fzd)] . Positive_regulation FZD4 WNT6 23146885 2703969 Itch directly associates with and ubiquitinates PI4KIIa , and both proteins colocalize on endosomes containing *activated* [frizzled 4 (Fz4)] receptor . Positive_regulation FZD9 WNT7A 16835228 1606475 and [Fzd 9] expression *resulted* in activation of ERK5 , which was required for PPARgamma activation in NSCLC . Positive_regulation G6PC FOXO1 11467835 840753 The insulin responsive H4IIEC3 rat hepatoma cell line ( H4 cells ) was used in order to determine the *role* of the transcription factor in the regulation of phosphoenolpyruvate carboxykinase ( PEPCK ) and [glucose-6-phosphatase (G6Pase)] . Positive_regulation G6PC FOXO1 12783775 1133975 Hepatic production *resulted* in inhibition of gluconeogenic activity , as evidenced by reduced PEPCK and [G-6-Pase] expression in the liver . Positive_regulation G6PC FOXO1 15256269 1272090 In contrast , stimulation of with tamoxifen *increased* the expression of the dexamethasone/cAMP induced G6Pase mRNA and the [G6Pase] enzymatic activity about 2.5- to 3-fold . Positive_regulation G6PC FOXO1 22232553 2563971 LRP6 ( +/- ) mice also exhibited reduced endogenous hepatic glucose output , which was due to diminished *dependent* expression of the key gluconeogenic enzyme [glucose-6-phosphatase (G6pase)] . Positive_regulation G6PC FOXO1 22291689 2520632 Gene expression of PEPCK and [G6Pase] was *regulated* by the transcription factor in HCV infected cells . Positive_regulation G6PC FOXO1 22384829 2566464 We also found that overexpression of GSK3ß potentiates [G6Pase] promoter *activation* by in a manner dependent on its kinase activity . Positive_regulation G6PC FOXO1 22384829 2566465 Treatment of SB-216763 diminishes *mediated* activation of [G6Pase] promoter . Positive_regulation G6PD IL1B 12475221 1023540 In conclusion , our data show that *stimulated* [G6PD] activity and expression level , providing NADPH that is required by iNOS for NO production in RINm5F cells . Positive_regulation G6PD IL1B 12475221 1023541 Also , inhibition of the cAMP dependent PKA signal pathway is involved in an *stimulated* increase in [G6PD] activity . Positive_regulation GAB1 EPHB2 11445578 850495 *regulates* the hepatocyte growth factor mediated interaction of [Gab1] and the phosphatidylinositol 3-kinase . Positive_regulation GAB1 EPHB2 11896055 944396 negatively *regulates* the epidermal growth factor mediated interaction of [Gab1] and the phosphatidylinositol 3-kinase . Positive_regulation GAB1 F2R 24025335 2857097 These novel observations reveal that thrombin induces monocyte/macrophage migration via *dependent* Pyk2 mediated [Gab1] and p115 RhoGEF interactions , leading to Rac1- and RhoA targeted Pak2 activation . Positive_regulation GAB1 PECAM1 20723025 2357015 To investigate the possibility that *regulates* the formation of the [Gab1-p85] signaling complexes , and the potential effect of such interactions on GPVI mediated platelet activation in platelets . Positive_regulation GAB2 EPHB2 16705167 1560773 Tcptp-/- macrophages also have increased tyrosine phosphorylation and recruitment of a [Grb2/Gab2/Shp2] complex to the CSF-1R and enhanced *activation* of after CSF-1 stimulation , which are important molecular events in CSF-1 induced differentiation . Positive_regulation GAB2 GAB3 11739737 897297 These results suggest that is important for macrophage differentiation and that differentiation *requires* the early phosphorylation of [Gab2] followed by induction and subsequent phosphorylation of Gab3 . Positive_regulation GAB3 CD40LG 10820273 694423 These studies show that coincident expression of enhances the Th1 ( IL-2 and IFN-gamma ) cytokine responses , increases the expression of TNF-alpha and NO , accelerates virus clearance , and *increases* the anti-F and [anti-G Ab] responses . Positive_regulation GAB3 GAB2 11739737 897298 These results suggest that [Gab3] is important for macrophage differentiation and that differentiation *requires* the early phosphorylation of followed by induction and subsequent phosphorylation of Gab3 . Positive_regulation GAB3 GAB2 17558859 1753197 A recent study demonstrated that [Gab] protein was over expressed in breast cancers , and the over expressed *increased* proliferation and invasion of the cells , indicating that Gab2 is an oncogenic protein . Positive_regulation GABPA EPHB2 15020583 1243427 Further investigation on the effects of the three MAPK pathways on Nrf2 transactivation domain activity demonstrated that both and JNK signaling pathways *stimulated* the [Gal4-Nrf2-] ( 1-370 ) transactivation activity while the p38 pathway played a negative role . Positive_regulation GABPA EPHB2 15292179 1296601 NADPH oxidase and signaling *regulates* hyperoxia induced [Nrf2-ARE] transcriptional response in pulmonary epithelial cells . Positive_regulation GABPA EPHB2 17433488 1766349 Among MAPK signaling pathways , p38 and *mediated* quercetin derived [Nrf2] translocation into nuclei and subsequent induction of HO-1 activity , and the latter showed a stronger mediating effect . Positive_regulation GABPA EPHB2 20302373 2238032 Neurotrophic and cytoprotective action of luteolin in PC12 cells through *dependent* induction of [Nrf2-driven] HO-1 expression . Positive_regulation GABPA EPHB2 21328610 2415084 Taken together , these results suggest that activation of Akt and is *required* for OA-induced activation of [Nrf2] followed by upregulation of HO-1 expression in VSMCs , which may confer an adaptive survival response in atherosclerosis . Positive_regulation GABPA EPHB2 23073806 2690050 Moreover , ß-PGG induced [Nrf2] nuclear translocation , which was found to be upstream of ß-PGG induced HO-1 expression , and the *activation* of and Akt , a pathway that is involved in ß-PGG induced Nrf2 nuclear translocation , HO-1 expression and neuroprotection . Positive_regulation GABPA TNF 18202225 1883781 We further demonstrated that [Nrf2] was *activated* by under NF-kappaB inhibited conditions , to play the major role in up-regulating HO-1 expression and ultimately the fate of AML cells . Positive_regulation GABPA TNF 21176673 2358242 After SCI , spinal cord water content , the expression of and MMP-9 all *increased* in both injured Nrf2 ( +/+ ) and [Nrf2] ( -/- ) mice compared with their respective sham operated mice . Positive_regulation GABRA1 IL1B 16567807 1562235 *enhances* [GABAA receptor] cell-surface expression by a phosphatidylinositol 3-kinase/Akt pathway : relevance to sepsis associated encephalopathy . Positive_regulation GABRA1 MAP2K6 10648867 662272 These results thus suggest that both BDNF dependent and -independent expressions of [GABA(A) receptor] subunits *require* the activation of and the mitogen activated protein kinase (MAPK) pathway . Positive_regulation GABRB2 IL1B 16567807 1562236 *enhances* [GABAA receptor] cell-surface expression by a phosphatidylinositol 3-kinase/Akt pathway : relevance to sepsis associated encephalopathy . Positive_regulation GABRB2 MAP2K6 10648867 662279 These results thus suggest that both BDNF dependent and -independent expressions of [GABA(A) receptor] subunits *require* the activation of and the mitogen activated protein kinase (MAPK) pathway . Positive_regulation GABRG2 IL1B 16567807 1562237 *enhances* [GABAA receptor] cell-surface expression by a phosphatidylinositol 3-kinase/Akt pathway : relevance to sepsis associated encephalopathy . Positive_regulation GABRG2 MAP2K6 10648867 662286 These results thus suggest that both BDNF dependent and -independent expressions of [GABA(A) receptor] subunits *require* the activation of and the mitogen activated protein kinase (MAPK) pathway . Positive_regulation GABRP FGF7 15912403 1433332 ( a mitogen of type II cells ) *increased* [GABRP] expression . Positive_regulation GAD1 NT5E 8283241 247465 [GAD] activity was *increased* by BDNF ( 1.8-fold ) and NT-3 ( threefold ) treatment , but not by , whereas GABA content was increased to a similar extent by all three neurotrophins . Positive_regulation GAD1 TF 3105814 72092 Insulin and were *necessary* and sufficient for neuronal survival , neurite extension and [glutamic acid decarboxylase (GAD)] expression . Positive_regulation GAD2 TNF 8781713 344302 2 ) at doses of 10 , 100 , 1000 U/ml which stimulated insulin secretion *had* no effect on [GAD-65] expression . Positive_regulation GADD45A CCND1 18798263 1969442 Both carotenoids induced cell cycle arrest during G ( 1 ) phase by reducing the expression of , cyclin D2 , CDK4 and CDK6 , and *inducing* the expression of [GADD45alpha] , and induced apoptosis by reducing the expression of Bcl-2 , XIAP , cIAP2 and survivin . Positive_regulation GADD45A FOXO1 16012755 1431697 In response to oxidative stress , accumulates within the nucleus and *induces* [GADD45] expression . Positive_regulation GADD45A FOXO1 16012755 1431702 mediated [GADD45] *induction* is markedly impaired in the cell , which depleted SIRT1 expression by RNA-interference . Positive_regulation GADD45A FOXO1 21196578 2396914 In response to nitric oxide , translocates from the cytoplasm to the nucleus and *stimulates* the expression of the DNA repair gene [GADD45a] , resulting in FoxO1 dependent DNA repair . Positive_regulation GADD45A FOXO1 21835778 2515972 We show here that Myc significantly and selectively contributes to repression of *mediated* expression of PUMA and [GADD45a] . Positive_regulation GADD45A TNF 16231353 1476751 We therefore investigated whether and NFB also *stimulated* [Gadd45] as part of the response to CAR ligands , or whether activation occurred by an alternative pathway . Positive_regulation GADD45B IL1B 16528573 1549439 Although *stimulated* the time dependent induction of endogenous [Gadd45b] in INS-1E cells and rat islets , expression levels were lower in these cells than in IL-1beta exposed NIH-3T3 and 3DO T cells . Positive_regulation GADD45B STAT4 12213961 985800 We show here that [GADD45-beta] and GADD45-gamma can *induce* S721 phosphorylation via the MKK6/p38 pathway . Positive_regulation GADD45B TP63 18331776 1904688 The results of western blot analysis further showed that increases of and p73 protein translation or stability might be *contribute* to the regulation of [GADD45beta] , 14-3-3sigma , cyclin B1 and PIG3 . Positive_regulation GADD45G EPHB2 11678615 873671 Oppositely , *activation* of , JNK and p38 by [Cr(VI)] does not affect cytotoxicity . Positive_regulation GADD45G STAT4 12213961 985801 We show here that GADD45-beta and [GADD45-gamma] can *induce* S721 phosphorylation via the MKK6/p38 pathway . Positive_regulation GAL CCND1 18045963 1832931 In Y1 cells , AVP blocks expression , *induces* senescence associated beta-galactosidase ( [SAbeta-Gal] ) and inhibits proliferation . Positive_regulation GAL CCND1 18045963 1832934 In addition , ectopic expression of the dominant negative RhoAN19 mutant blocks RhoA activation , yielding Y1 cell sub-lines which are no longer susceptible to downregulation , [SAbeta-Gal] *induction* , or proliferation inhibition by AVP . Positive_regulation GAL GNE 16847058 1606781 Cellular responses to the *mediated* changes in [ST3Gal5] and ST8Sia1 expression and GM3 and GD3 levels were investigated next . Positive_regulation GAL IL1B 18592145 1941331 Stimulation of synoviocytes by in cell cultures significantly *increased* the activity of HEX , HEX-A , and GluA in both compartments , as well as of [GAL] , MAN , and FUC in the intracellular compartment . Positive_regulation GAL TLR7 20727792 2313128 Thus , we present *dependent* negative regulation of [alpha-Gal-A] as a mechanistic link between pathogen recognition and self lipid antigen induction for NKT cells . Positive_regulation GAL TNF 15087472 1258126 and IL-1 induced a time- and dose dependent *increase* in [galanin] , vasoactive intestinal polypeptide , and secretogranin II mRNA levels . Positive_regulation GAL TNF 22101519 2514309 Flagellin , IL-13 and all significantly *increased* [GAL3ST2] , MUC2 , TFF3 and TLR5 expression , while only IL-13 increased RETNLB and CHST5 expression . Positive_regulation GAL TNF 24065781 2902477 Unmodified [GAL] siRNA transiently *induced* the expression of , IL-6 , IL-10 , IFN-ß and IFN-sensitive gene 15 in vivo , whereas a formulation of 2'-O-methylated-LUC siRNA had no such effects . Positive_regulation GALM TNF 18052213 1833279 In contrast , did not *increase* [GALM] mRNA expression , although it is capable of inducing cell differentiation . Positive_regulation GALT TNF 16100442 1444105 *enhanced* CGT , GalT2 and [GalT6] mRNA levels and EGCG suppressed the level of these enzymes enhanced by TNF-alpha treatment . Positive_regulation GALT TNF 17712626 1866056 Both anti-TNFR1 and anti-TNFR2 antibodies suppressed [beta-1,4-GalT] I mRNA expression *induced* by or LPS . Positive_regulation GALT TNF 20886274 2504618 In addition , we observed that not only endogenous TNF-a but also exogenous *induced* [ß1,4-GalT-I] mRNA production in FLSs , and TNF-a-knockdown reverses the up-regulation of ß1,4-GalT-I in FLSs induced by LPS or TNF-a . Positive_regulation GAP43 MAP2K6 21769916 2494728 In TGW cells , PD98059 , a inhibitor , but not SB203580 ( a p38 MAPK inhibitor ) and LY294002 ( a PI3K inhibitor ) *inhibited* GDNF induced [GAP43] expression , suggesting the MEK/ERK pathway has a major role in GDNF induced GAP43 transcription . Positive_regulation GAP43 NT5E 9391013 467690 BDNF and prevent atrophy of rat rubrospinal neurons after cervical axotomy , *stimulate* [GAP-43] and Talpha1-tubulin mRNA expression , and promote axonal regeneration . Positive_regulation GAP43 SPHK1 17555548 1778564 Silencing of using siRNA *inhibited* GDNF induced neurite formation , [GAP43] expression , and cell growth , suggesting the important role of SPHK1 in GDNF signal transduction . Positive_regulation GAP43 SPHK1 21769916 2494718 Stable wild-type ( SPHK1-WT ) but not dominant negative ( SPHK1-DN ) overexpression *increased* both control- and GDNF induced [GAP43] expression . Positive_regulation GAPDH IL1B 19060282 2047441 ( 1-10 ng/mL ) significantly *increased* [GAPDH] nuclear accumulation in Müller cells in a concentration dependent manner within 24 hours . Positive_regulation GAPDH IL1B 19060282 2047442 Further , high glucose induced [GAPDH] nuclear accumulation in Müller cells was *mediated* by . Positive_regulation GAPDH IL1B 19060282 2047444 In contrast , IL-6 ( 2 ng/mL ) had a strong protective effect attenuating high glucose and *induced* [GAPDH] nuclear accumulation in Müller cells . Positive_regulation GAS2 CAPN8 11387205 821737 Moreover , we demonstrate that [Gas2] physically interacts with m-calpain in vivo and that recombinant Gas2 inhibits *dependent* processing of p53 . Positive_regulation GAST ARSA 20443220 2256977 In this study , we designed to determine the effects of melatonin and l-tryptophan on *induced* gastric mucosal damage , gastric microbleeding , mucosal generation of prostaglandin E ( 2 ) , and plasma melatonin , and [gastrin] levels . Positive_regulation GAST CA12 173424 2805 The results obtained suggest that the *activation* of in vivo by [gastrin] ( pentagastrin ) , histamine and 3',5'-AMP is due to the phosphorylation of highly active isoenzyme by 3',5-AMP dependent protein kinase . Positive_regulation GAST CLU 21995960 2526105 We show that the gastric hormone [gastrin] *induces* the expression of the prosurvival secretory ( sCLU ) in rat adenocarcinoma cells . Positive_regulation GAST HBEGF 9869605 583150 [Gastrin] *induced* expression of HB-EGF mRNA , processing of proHB-EGF , release of into the medium , and tyrosine phosphorylation of the EGF receptor . Positive_regulation GAST IL1B 21445336 2412248 induced Smad 7 negatively *regulates* [gastrin] expression . Positive_regulation GAST IL1B 8536851 346146 ( 50 % effective concentration [ EC50 ] , 5.3 +/- 0.4 ng/mL ) and tumor necrosis factor (TNF) alpha ( EC50 , 5.5 +/- 0.5 ng/mL ) *stimulated* [gastrin] release to 50 % of the maximal response to 10 ( -9 ) mol/L neuromedin C. Stimulation by the maximally effective concentration of IL-1 beta ( 10 ng/mL ) was inhibited by the human IL-1 receptor antagonist ( 100 ng/mL ; inhibitory constant , 23.0 ng/mL ) , which prefers type I over type II IL-1 receptors . Positive_regulation GAST IL1B 8536851 346149 and TNF-alpha *stimulate* [gastrin] secretion via receptors potentially residing on rabbit antral G cells themselves . Positive_regulation GAST ITGB2 15004185 1217405 We conclude that M5 protein interferes with the *dependent* association between [GAS] and neutrophils , and thereby blocks subsequent ingestion of the bacteria . Positive_regulation GAST MAP2K6 12761477 1091545 A transiently transfected activated ras vector stimulated [gastrin/CCKB] receptor transcriptional activities in both Colo320HSR and LoVo cells , but these ras increased activities were *inhibited* by a specific inhibitor , PD98059 . Positive_regulation GAST TNF 8536851 346148 IL-1 beta and *stimulate* [gastrin] secretion via receptors potentially residing on rabbit antral G cells themselves . Positive_regulation GAST TNF 8997237 404527 Accordingly , overexpression of c-fos mRNA facilitated primarily EGF rather than *induction* of the [gastrin] promoter . Positive_regulation GAST TNF 9758167 535972 The existence of a synergism between IFN-gamma and TNF-alpha in stimulating IRF-1 expression at the transcriptional level was supported by IRF-1 promoter analysis : IFN-gamma directly *induced* the binding of STAT-1 homodimers to the [GAS] element , while NF-kappaB binding to the kappaB sequence was activated by only after IFN-gamma treatment . Positive_regulation GATA1 FAS 16384930 1547183 JAK2 mutated PV erythroblasts showed lower levels of *induced* caspase activation and incomplete caspase mediated cleavage of the erythroid transcription factor [GATA-1] , which was entirely degraded in normal erythroblasts on CD95 stimulation . Positive_regulation GATA1 STK39 16204311 1507829 AKT phosphorylates GATA-1S310 in vitro and in erythroid cells and *enhances* [GATA-1] transcriptional activity . Positive_regulation GATA3 FOXA1 20501593 2263819 Using breast cancer cell lines , we also demonstrate that *regulates* ERalpha expression , but not [GATA3] . Positive_regulation GATA3 TNF 17553612 1773652 In precultured CD34+CD38- CB cells , *increased* [GATA3] but decreased EBF1 expression , in line with the skewed lymphoid differentiation induced by TNF . Positive_regulation GATA3 TP63 19719829 2247687 binds and *transactivates* the [GATA-3] promoter . Positive_regulation GATA4 EPHB2 12468531 1055259 These results demonstrate that HGF protects cardiac muscle cells against apoptosis via a signaling pathway involving *dependent* phosphorylation of [GATA-4] . Positive_regulation GATA4 EPHB2 19432968 2084105 Thrombin induces Egr-1 expression in fibroblasts involving elevation of the intracellular Ca2+ concentration , phosphorylation of and *activation* of [ternary complex] factor . Positive_regulation GATA4 EPHB2 21702924 2455699 Hyperglycemia can cause systolic dysfunction and a higher expression of cTnI in cardiomyocytes through ROS , enhancing *induced* [GATA-4] phosphorylation and accumulation in the cell nucleus . Positive_regulation GATA4 EPHB2 22674427 2715285 Inhibition of activity by U0126 , *suppressed* EPO induced expression of [GATA-4] protein in rat cardiac myocytes . Positive_regulation GATA4 EPHB2 22674427 2715288 In addition , activation by over-expression of constitutively active MEK1 strongly *increased* [GATA-4] phosphorylation and subsequently enhanced its acetylation in P19 cells . Positive_regulation GATA4 EPHB2 22674427 2715291 EPO induced activation further *increased* the association of [GATA-4] with p300 . Positive_regulation GATA4 EPHB2 22674427 2715294 Taken together , these results indicated that EPO induced signaling activation *increased* [GATA-4] phosphorylation and acetylation , partly via increase in the association between GATA-4 and p300 , and these processes required the phosphorylation of GATA-4 at Ser-261 residue . Positive_regulation GATA4 EPHB2 23811561 2808180 activation by over-expression of constitutively active mitogen activated protein kinase 1 ( MEK1 ) strongly *increased* [GATA-4] phosphorylation and its protein levels and decreased GATA-4 ubiquitination under hypoxia . Positive_regulation GATA4 MAP2K6 11841924 912288 PMA also phosphorylated MEK and ERK , and PMA induced [GATA-4] phosphorylation was *blocked* by an inhibitor , PD98059 , suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway . Positive_regulation GATA4 MAP2K6 12468531 1055265 These results demonstrate that HGF protects cardiac muscle cells against apoptosis via a signaling pathway involving *dependent* phosphorylation of [GATA-4] . Positive_regulation GATA4 MAP2K6 21702924 2455705 Hyperglycemia can cause systolic dysfunction and a higher expression of cTnI in cardiomyocytes through ROS , enhancing *induced* [GATA-4] phosphorylation and accumulation in the cell nucleus . Positive_regulation GATA4 NR2F1 18177425 1951109 Specifically , overexpression *increased* mRNA levels of GATA6 by 3.3+/-0.3-fold , [GATA4] by 3.6+/-0.1-fold , laminin B1 (LAMB1) by 3.4+/-0.1-fold , LAMC1 by 3.4+/-0.2-fold , Dab2 by 2.4+0.1-fold , and SOX17 by 2.5-fold at 72 hr after RA treatment plus LIF , as compared with the increases seen in WT ES cells . Positive_regulation GATA4 NRARP 11485984 845015 We show that Nrarp forms a [ternary complex] with the ICD of XNotch1 and the CSL protein XSu ( H ) and that in embryos *promotes* the loss of ICD . Positive_regulation GATA4 TNF 19627149 2180265 Moreover , pretreatment with a Jak/STAT inhibitor decreased *induced* VCAM-1 expression and nuclear [GATA-4] , GATA-6 , and IRF-1 levels . Positive_regulation GATA6 EPHB2 18454176 1951515 Oncogenic Ras upregulates NADPH oxidase 1 gene expression through *dependent* phosphorylation of [GATA-6] . Positive_regulation GATA6 EPHB2 18454176 1951547 On the basis of these results , we propose that oncogenic Ras signaling upregulates the transcription of Nox1 through *dependent* phosphorylation of [GATA-6] . Positive_regulation GATA6 MAP2K6 18454176 1951521 Oncogenic Ras upregulates NADPH oxidase 1 gene expression through *dependent* phosphorylation of [GATA-6] . Positive_regulation GATA6 MAP2K6 18454176 1951553 On the basis of these results , we propose that oncogenic Ras signaling upregulates the transcription of Nox1 through *dependent* phosphorylation of [GATA-6] . Positive_regulation GATA6 NR2F1 18177425 1951110 Specifically , overexpression *increased* mRNA levels of [GATA6] by 3.3+/-0.3-fold , GATA4 by 3.6+/-0.1-fold , laminin B1 (LAMB1) by 3.4+/-0.1-fold , LAMC1 by 3.4+/-0.2-fold , Dab2 by 2.4+0.1-fold , and SOX17 by 2.5-fold at 72 hr after RA treatment plus LIF , as compared with the increases seen in WT ES cells . Positive_regulation GATA6 PLAU 21076612 2345135 Accordingly , GATA6 physically associated with Sp1 and siRNA knockdown of Sp1 decreased GATA6 activation of the uPA promoter activity suggesting that Sp1 recruits GATA6 to the uPA promoter and mediates [GATA6] induced *activation* of the promoter activity . Positive_regulation GATA6 TNF 11397697 823826 Electrophoretic mobility shift assay showed that stimulation *increased* the DNA binding of [GATA-6] but decreased that of GATA-3 . Positive_regulation GATA6 TNF 19627149 2180266 Moreover , pretreatment with a Jak/STAT inhibitor decreased *induced* VCAM-1 expression and nuclear GATA-4 , [GATA-6] , and IRF-1 levels . Positive_regulation GATA6 TNF 22898620 2687669 Treatment of VSMCs with sulforaphane blocked *induced* I?Ba degradation and NF-?B p65 and [GATA6] expression . Positive_regulation GATAD2B IL1B 16847181 1588129 The messenger RNA expressions of [LARC] ( liver and activation regulated chemokine ) , GMCSF ( granulocyte-macrophage colony stimulating factor ) , epiregulin , ICAM1 ( intercellular adhesion molecule 1 ) , and TGFA ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation GBP1 IL1B 14741045 1226109 In the present study , we identified a NF-kappaB ( nuclear factor kappaB ) -binding motif that , together with ISRE , is required for the *induction* of [GBP-1] expression by and tumour necrosis factor-alpha . Positive_regulation GBP1 IL1B 17266443 1691425 IFN-gamma , tumor necrosis factor-alpha (TNF-alpha) , and *induced* the expression of [HuGBP-1] , HuGBP-2 , and HuGBP-3 at similar high levels . Positive_regulation GBP1 TNF 22692453 2686982 IFN-? and *induced* [GBP-1] inhibits epithelial cell proliferation through suppression of ß-catenin/TCF signaling . Positive_regulation GBP1 TNF 25272603 2958973 Recent studies have proved that IFN-alpha , IFN-beta , IFN-gamma , IL1alpha , IL1beta , and LPS can *induce* [GBP1] expression ; Positive_regulation GBP2 IL1B 17266443 1691426 IFN-gamma , tumor necrosis factor-alpha (TNF-alpha) , and *induced* the expression of HuGBP-1 , [HuGBP-2] , and HuGBP-3 at similar high levels . Positive_regulation GC ADRB2 1279289 202986 Terbutaline desensitized all in vivo effects involving beta 2-adrenoceptors ( ISO induced decrease in [DBP] and increase in plasma NE and , to a minor extent , the mixed beta 1- and mediated *increase* in HR ) , but did not affect beta 1-adrenoceptor mediated in vivo effects ; Positive_regulation GC GLP1R 16257226 1518296 Here , we show by microarray analysis that hippocampal activation of ( GLP-1R ) , which is associated with improved learning and neuroprotection , *results* in suppression of the transcription factor [DBP] ( albumin D-site binding protein ) . Positive_regulation GCDH SPRR1B 19365590 2058693 Compared to Aire-sufficient controls , conjunctival [goblet cell density (GCD)] decreased and corneal *increased* in Aire-deficient mice with significant differences noted at both 8 and 16 weeks . Positive_regulation GCG ADRB2 22013013 2507841 The [glucagon] response was also *increased* by activation by 63 % ( P < 0.01 ) . Positive_regulation GCG ARSA 7043491 20699 The *had* no significant effect on plasma [glucagon] or gastric inhibitory polypeptide in either group I or group II . Positive_regulation GCG CFI 2221580 142845 can inhibit C5a directed neutrophil chemotaxis by binding to the C5a cochemotaxin GcGlobulin ( GcG ) , a vitamin-D binding protein , and *inhibiting* the capacity of [GcG] to enhance the chemotactic activity of C5a . Positive_regulation GCG CFI 2221580 142846 Because cigarette smoke can inhibit the function of some proteins , a loss of functional activity induced by cigarette smoke would *allow* an increased capacity of [GcG] to augment C5a directed neutrophil chemotaxis . Positive_regulation GCG FOXA1 10920385 762516 is *required* for the full activation of [glucagon] in the pancreas , whereas HNF3 gamma induces the activation of gluconeogenic enzymes to prevent hypoglycemia during fasting . Positive_regulation GCG GLP1R 21441444 2421879 Blocking endogenous action increased endogenous GLP-1 secretion in all groups and *increased* postprandial glucose , [glucagon] , and GE in T1D+ and T1D- patients . Positive_regulation GCG GLP1R 22916913 2657722 The predominant expression of PYY , Y2 , and [GCG] in the gut , and the *presence* of in multiple peripheral tissues suggest a role for PYY in controlling gut functions and for GLP-1 in regulating multiple physiological functions in cattle . Positive_regulation GCG GPR115 23269670 2741485 The family C group 6 subtype A ( GPRC6A ) receptor is *involved* in amino acid induced [glucagon-like] peptide-1 secretion from GLUTag cells . Positive_regulation GCG GPR132 23269670 2741474 The family C group 6 subtype A ( GPRC6A ) receptor is *involved* in amino acid induced [glucagon-like] peptide-1 secretion from GLUTag cells . Positive_regulation GCG GPR87 23269670 2741554 The family C group 6 subtype A ( GPRC6A ) receptor is *involved* in amino acid induced [glucagon-like] peptide-1 secretion from GLUTag cells . Positive_regulation GCG IGFBP1 16455781 1547956 The expression of is *induced* in rat liver by dexamethasone and [glucagon] and is completely inhibited by 100 nM insulin . Positive_regulation GCG IL1B 2406177 128066 [Glucagon] secretion was also *stimulated* by recombinant , irrespective of increasing glucose ( 5 , 11 , 20 mmol/l ) and insulin concentrations . Positive_regulation GCG IL1B 8405744 232436 In contrast , *stimulated* islet [glucagon] release was completely antagonised by a 100-fold molar excess of interleukin-1 receptor antagonist . Positive_regulation GCG NT5E 6097328 44033 An inhibitor of <5' nucleotidase> , alpha , beta-methylene ADP ( 16.5 microM ) , *reduced* the [glucagon] increase induced by ATP and did not affect the response to adenosine ( 1.65 microM ) . Positive_regulation GCH1 IL1B 10435048 634266 The simplest explanation of these results is that *induces* expression of [GTP cyclohydrolase-1] which leads to increased generation of BH4 and activation of eNOS . Positive_regulation GCH1 IL1B 12491784 1026100 S1P also significantly inhibited [GTP cyclohydrolase I (GTPCH)] mRNA expression *induced* by . Positive_regulation GCH1 IL1B 18171908 1883115 S1P also inhibited *induced* [GTP cyclohydrolase I (GTPCH)] mRNA expression . Positive_regulation GCH1 IL1B 7514193 254026 IFN-gamma plus TNF or *increased* endogenous tetrahydrobiopterin levels and [GTP cyclohydrolase I] activity , the rate limiting enzyme of tetrahydrobiopterin synthesis . Positive_regulation GCH1 IL1B 8809061 383056 In the present paper we demonstrate that and cAMP similarly *increase* the steady-state mRNA levels of [GTP cyclohydrolase I] ( EC 3,5,4,16 ) , the rate limiting enzyme in BH4 biosynthesis , as measured by a sensitive and quantitative nuclease protection assay . Positive_regulation GCH1 IL1B 8809061 383057 Furthermore , and cAMP *led* to a marked increase in [GTP cyclohydrolase I] activity and to increased accumulation of biopterin in mesangial cells . Positive_regulation GCH1 MMP28 15502346 1327238 Thus inhibitors might *prevent* [GCH] by inhibiting transactivation of EGFR . Positive_regulation GCH1 MMP7 15502346 1327275 Thus inhibitors might *prevent* [GCH] by inhibiting transactivation of EGFR . Positive_regulation GCH1 TNF 15604419 1369077 Conversely , overexpression of Jak2 effectively substituted for IFN-gamma in supporting mediated [GTPCH I] *induction* . Positive_regulation GCH1 TNF 15604419 1369078 However , Stat1 activation with oncostatin M failed to support mediated [GTPCH I] *induction* because of concomitant Stat3 activation . Positive_regulation GCH1 TNF 24220333 2879494 The same enhancer region was also responsible for the *induction* of the [GCH] gene by IFN-? and in HUVECs . Positive_regulation GCH1 TNF 7514193 254024 IFN-gamma plus or IL-1 beta *increased* endogenous tetrahydrobiopterin levels and [GTP cyclohydrolase I] activity , the rate limiting enzyme of tetrahydrobiopterin synthesis . Positive_regulation GCHFR CAPN8 11231011 789453 Here we show that [p35] is rapidly cleaved to p25 in rat and human brains within a short postmortem delay and that the conversion of p35 to p25 is partially *dependent* on activity . Positive_regulation GCHFR CAPN8 17121855 1686399 Suppression of *dependent* cleavage of the CDK5 activator [p35] to p25 by site-specific phosphorylation . Positive_regulation GCHFR CAPN8 17506859 1750952 We show here that endoplasmic reticulum ( ER ) stress causes the *dependent* cleavage of [p35] to p25 in primary cultured cortical neurons . Positive_regulation GCHFR CAPN8 18242949 1877084 The cleavage of [p35] is *caused* by calcium ( Ca2+ ) induced activation of . Positive_regulation GCHFR CAPN8 18242949 1877098 Inhibition of activity by calpeptin *prevents* cleavage of [p35] to p25 . Positive_regulation GCHFR CAPN8 18289510 1878512 The cleavage of [p35] to p25 , *mediated* by and calcium , caused CDK5 dislocation and subsequently p25/CDK5 induced tau hyperphosphorylation , which disrupted the cytoskeleton and resulted in neuronal death . Positive_regulation GCHFR CAPN8 20518484 2277035 Alternatively , *induced* cleavage of [p35] to p25 can induce aberrant Cdk5 activation . Positive_regulation GCHFR EPHB2 11331872 808917 Furthermore , the transcription factor Egr1 , is induced by NGF through the ERK pathway and mediates *induction* of [p35] by . Positive_regulation GCHFR EPHB2 12807488 1102102 Thus , whilst LPS induced p38 mitogen activated protein kinase ( MAPkinase ) activation is required for the induction of both p40 and p35 subunits , MAPkinase signalling *mediates* negative feedback regulation of p40 , but not [p35] , production . Positive_regulation GCHFR EPHB2 18438930 1932624 Thus , *dependent* [p35] up-regulation and MAPK/ERK dependent and PI3K/Akt dependent Bcl2 up-regulation contribute to BDNF stimulated neural differentiation and to the survival of differentiated cells . Positive_regulation GCHFR FAS 12545171 1051109 Here we report that crosslinking on primary sensory neurons *induces* neurite growth through sustained activation of the extracellular-signal regulated kinase ( ERK ) pathway and the consequent upregulation of [p35] , a mediator of neurite outgrowth . Positive_regulation GCHFR IL1B 17569750 1774227 also *promotes* the [p35] expression , a subunit of IL-12 , but weakly . Positive_regulation GCHFR ITGB2 11123339 768813 In contrast , for optimal induction of COX-2 , IL-12 [p35] , and IL-12 p40 genes by low concentrations of LPS or by all concentrations of Taxol , was also *required* . Positive_regulation GCHFR NES 12832492 1105743 In differentiating myoblasts , p35 was not complexed with phosphorylated at Thr-316 , and inhibition of cdk5 activity during differentiation *induced* a marked association of [p35] with nestin . Positive_regulation GCHFR NES 21278733 2409627 We found that the intermediate filament protein physically interacts with Cdk5 and is *required* for ACh induced association of [p35] , the co-activator of Cdk5 , with the muscle membrane . Positive_regulation GCHFR TLR7 15851485 1399514 Moreover , analysis of interferon regulatory factors (IRF) regulation in moDC suggests a role for IRF7/8 in mediating IRF3 independent type I IFN and possibly [IL-12p35] synthesis in *response* to . Positive_regulation GCHFR TNF 19049962 2023755 Our results indicate that *activates* [p35] promoter activity in a dose- and time dependent manner and concomitantly up-regulates Cdk5 activity . Positive_regulation GCK GLP1R 22580530 2598677 This beneficial effect of exendin-4 on liver [glucokinase] activity may be *mediated* by . Positive_regulation GCKR TNF 9405407 469814 A TRAF2 mutant , which inhibits both TRAF2 induced NF-kappaB and SAPK activation , blocked *induced* [GCKR] activation . Positive_regulation GCLC EPHB2 12657749 1080099 Pyrrolidine dithiocarbamate ( PDTC ) induction of the human [glutamate cysteine ligase] modulatory ( GCLM ) gene is *dependent* on activation of the mitogen activated protein kinases ( MAPKs ) and p38 , and is not affected by protein kinase C ( PKC ) or PI3K inhibitors . Positive_regulation GCLC IL1B 11025451 738537 *Induction* of MRP1 and [gamma-glutamylcysteine synthetase] gene expression by is mediated by nitric oxide related signalings in human colorectal cancer cells . Positive_regulation GCLC IL1B 15485876 1347368 We designed experiments to ascertain whether [GCLC] is normally expressed in islets and whether it is *up-regulated* by . Positive_regulation GCLC IL1B 15485876 1347369 *up-regulated* [GCLC] expression ( 10 ng/ml IL-1 beta , 3.76 +/- 0.86 ; 100 ng/ml IL-1 beta , 4.22 +/- 0.68-fold control ) via the p38 form of mitogen activated protein kinase and NF kappa B and also increased reactive oxygen species levels ( 10 ng/ml IL-1 beta , 5.41 +/- 1.8-fold control ) . Positive_regulation GCLM EPHB2 12657749 1080101 Pyrrolidine dithiocarbamate ( PDTC ) induction of the human glutamate cysteine ligase modulatory ( [GCLM] ) gene is *dependent* on activation of the mitogen activated protein kinases ( MAPKs ) and p38 , and is not affected by protein kinase C ( PKC ) or PI3K inhibitors . Positive_regulation GCLM TNF 16011481 1459387 *induces* the expression and recombinant promoter activities of GCLC , [GCLM] and GSS in H4IIE cells . Positive_regulation GCLM TNF 16011481 1459402 TNFalpha treatment resulted in increased c-Jun and Nrf2 ( nuclear factor erythroid 2-related factor 2 ) nuclear binding to the antioxidant response element of the rat GCLM and if this was prevented , no longer *induced* the [GCLM] promoter activity . Positive_regulation GCM1 MAP2K6 22206674 2544282 The phosphorylation and degradation of [GCMa] by PMA treatment was effectively *reduced* by pretreatment with protein kinase C ( PKC ) inhibitors and a mitogen activated protein kinase (MAPK) kinase ( ) inhibitor , indicating a PKC- and MEK dependent mechanism . Positive_regulation GCM1 S100B 14573516 1158747 In particular , mouse [Gcm1] *induced* the expression of astrocyte-specific Ca ( 2+ ) -binding protein , , in those cells . Positive_regulation GCNT1 TNF 22182514 2543301 *induced* [C2GNT] activity ( 1813±326 pmol/h/mg protein ) ( mean±SEM ) in human leukocytes was significantly reversed with apocynin ( 153±82 pmol/h/mg protein ) , unscrambled gp91ds-tat ( 244±122 pmol/h/mg protein ) and tiron ( 756±87 pmol/h/mg protein ) . Positive_regulation GCNT1 TNF 22182514 2543307 The deficiency in p47phox prevented *induced* NADPH oxidase and [C2GNT] activity and adherence to endothelial cells . Positive_regulation GCNT2 HBEGF 22716246 2616417 *Upregulation* of [N-acetylglucosaminyltransferase-V] by induces keratinocyte proliferation and epidermal hyperplasia . Positive_regulation GCNT3 TNF 15864435 1401347 *induced* expression of hST3GalIV , FUT3 , [C2/4GnT] and MUC5AC mRNAs in NCI-H292 cells . Positive_regulation GCSH IL1B 11025451 738539 These results suggest that mediated MRP1 and [gamma-GCSh] *induction* involve nitric oxide ( NO ) -related signaling . Positive_regulation GCSH IL1B 11025451 738544 Collectively , our results demonstrate that *induction* of MRP1 and [gamma-GCSh] by is regulated , at least in part , by an NO-related signaling , and induction of gamma-GCSh is by NO-related ceramide signaling . Positive_regulation GDA EPHB2 22977256 2688590 [GdA] also *induced* phosphorylation of in monocytes/macrophages . Positive_regulation GDF15 EPHB2 15555917 1340102 NRG-1beta effects on neurite extension and arborization are similar to , but not additive with , those of brain derived neurotrophic factor and reflect direct NRG-1 action on hippocampal neurons as these cells express the NRG-1 receptors erbB2 and erbB4 , the erbB-specific inhibitor PD158780 decreases NRG-1beta induced neurite outgrowth , and [NRG-1beta] stimulation *induces* p42/44 phosphorylation . Positive_regulation GDF15 EPHB2 18164124 1869580 Adipocyte culture medium- and palmitate induced [MIC-1] gene expression was *mediated* by the activation of p38 MAPK , but not by the activation of JNK , , and NF-kappaB pathway . Positive_regulation GDF15 MAP2K6 18413810 1894230 Forced expression of constitutively active MKK6 , an upstream kinase for p38 , induced an increase in NAG-1 promoter activity , whereas p38 kinase inhibitor blocked *induced* increase in [NAG-1] promoter activity . Positive_regulation GDF15 MAP2K6 22410117 2582309 Inhibitors of ( PD98059 ) and p38 MAP kinase ( SB203580 ) *prevented* rottlerin induced [NAG-1] expression . Positive_regulation GDF15 TNF 15897808 1408658 Although *induced* [GDF-15] expression , injury elicited Gdf15 expression was not reduced in mice deficient for both TNF receptor subtype . Positive_regulation GDF15 TNF 16154591 1499441 Although *induced* [GDF-15] expression , injury elicited Gdf15 expression was not reduced in mice deficient for both TNF receptor subtypes . Positive_regulation GDF15 TP63 17637746 1848566 Consistent with these results , the proximal binding site within the GDF15 promoter region was *required* for the TAp63alpha mediated transcriptional activation of [GDF15] , and TAp63alpha was recruited onto this site . Positive_regulation GDF2 ID1 22622516 2632464 [BMP9] *induces* both and ID3 , and both are necessary for full induction of EphrinB2 . Positive_regulation GDF2 ID1 22622516 2632474 Conversely , [BMP9] blocks EC sprouting and this is *dependent* on Alk1 , BMPRII/ActRII and . Positive_regulation GDNF EPHB2 16537917 1536918 We correlate the findings to intact porcine retina , where [GDNF] *induces* phosphorylation of in the perinuclear region of RMG located in the inner nuclear layer . Positive_regulation GDNF EPHB2 17210798 1709554 The extent of acute ERK activation and GDNF release were significantly correlated to each other in individual antidepressants , suggesting an important *role* of acute activation in [GDNF] production . Positive_regulation GDNF EPHB2 17210798 1709560 Taken together , these findings indicate that activation through PTK *regulates* antidepressant induced [GDNF] production and that the GDNF production in glial cells may be a novel action of the antidepressant , which is independent of monoamine . Positive_regulation GDNF EPHB2 19277011 2079804 However , only nigrostriatal [GDNF] overexpression *induced* activation of phosphorylated extracellular signal regulated kinase ( ) in a small population of corticotrophin releasing factor [corticotrophin releasing hormone (CRH) ] neurons located specifically in the medial parvocellullar division ( MPD ) of the paraventricular nucleus of the hypothalamus . Positive_regulation GDNF EPHB2 19399830 2082271 Taken together , these results suggest that the [GDNF] *acts* through , which in turn activates IKKalpha/beta and NF-kappaB , resulting in the activations of alphavbeta3 integrin and contributing the migration of human chondrosarcoma cells . Positive_regulation GDNF EPHB2 21767553 2521457 Our results reveal the release of [GDNF] as a *consequence* of signalling activation by norquetiapine , which may contribute to the putative antidepressant properties of quetiapine . Positive_regulation GDNF EPHB2 23797152 2838754 Our aim was to investigate whether Fyn kinase , and PI3K/Akt signaling pathways are *required* for [aTf-stimulation] of oligodendrocyte differentiation and also to determine if the transferrin receptor is involved in these mechanisms . Positive_regulation GDNF EPHB2 23897718 2866037 We found that ERK1/2 is periodically activated in Sertoli cells during the stem cell self-renewal/proliferation phase , and that signaling is *required* for the stage related expression of the critical niche factor [GDNF] . Positive_regulation GDNF IL1B 16497991 1548954 Electrophoretic gel mobility shift assays showed that *increased* the binding of phosphorylated ATF2 to [CRE/ATF] . Positive_regulation GDNF IL1B 17027275 1666389 *mediates* [GDNF] up-regulation upon dopaminergic injury in ventral midbrain cell cultures . Positive_regulation GDNF IL1B 17348037 1741092 All three stimuli increased PGHS-2 and IL-8 mRNA expression in a MAPK dependent manner , but while the MAPK inhibitors reduced the *induced* activation of [activating transcription factor (ATF)-2] , liver activating protein (LAP) and c-jun , the stretch induced increase in LAP was unaffected by MAPK-inhibition and only JNK inhibition appeared to reduce c-jun activation . Positive_regulation GDNF IL1B 19362079 2081439 Mechanisms of *induced* [GDNF] release from rat glioma cells . Positive_regulation GDNF IL1B 19362079 2081440 Herein , we investigated the mechanisms of the *induced* [GDNF] release from rat C6 glioma cells . Positive_regulation GDNF IL1B 19362079 2081467 The *stimulated* levels of [GDNF] were suppressed by wedelolactone , an inhibitor of IkappaB kinase , SB203580 , an inhibitor of p38 MAP kinase , PD98059 , an inhibitor of MAP kinase kinase 1/2 or Janus family of tyrosine kinase (JAK) inhibitor I , an inhibitor of upstream kinase of STAT3 . Positive_regulation GDNF MAP2K6 19399830 2082277 Taken together , these results suggest that the [GDNF] *acts* through , which in turn activates IKKalpha/beta and NF-kappaB , resulting in the activations of alphavbeta3 integrin and contributing the migration of human chondrosarcoma cells . Positive_regulation GDNF MAP2K6 23797152 2838763 Our aim was to investigate whether Fyn kinase , and PI3K/Akt signaling pathways are *required* for [aTf-stimulation] of oligodendrocyte differentiation and also to determine if the transferrin receptor is involved in these mechanisms . Positive_regulation GDNF MAP2K6 23897718 2866043 We found that ERK1/2 is periodically activated in Sertoli cells during the stem cell self-renewal/proliferation phase , and that signaling is *required* for the stage related expression of the critical niche factor [GDNF] . Positive_regulation GDNF PLAU 9974409 596528 Using electrophoretic mobility shift and supershift assays , we then demonstrated that Stat1 is rapidly activated in endothelial cells in *response* to and [ATF] . Positive_regulation GDNF TNF 16956589 1627641 The *role* of and its receptors in the production of NGF and [GDNF] by astrocytes . Positive_regulation GDNF TNF 16956589 1627647 In addition , we observe that not only exogenous but also TNF-alpha produced by astrocytes *induce* NGF and [GDNF] production in astrocytes . Positive_regulation GDNF TNF 20601681 2303798 We also tested whether [GDNF] production is *regulated* by or tryptase , the products of mast cells or macrophages . Positive_regulation GDNF TNF 20601681 2303800 and tryptase *had* no effect on the secretion of [GDNF] by HTPCs or HTPC-Fs . Positive_regulation GDNF TNF 22512503 2595646 QRT-PCR analysis revealed that IL-1ß and significantly *increased* the expression of [GDNF] in HPDLCs . Positive_regulation GEMIN2 SMN2 10369862 621807 In SMA patients , the loss of SMN1 but the presence of *results* in low levels of full-length [SMN] transcript and therefore low SMN protein levels which causes SMA . Positive_regulation GEMIN2 SMN2 10500148 648003 Moreover , we show that [SMN] , but not mutants found in SMA patients , can form large oligomers and that oligomerization is *required* for high-affinity binding to spliceosomal snRNP Sm proteins . Positive_regulation GEMIN2 SMN2 10767334 684864 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Positive_regulation GEMIN2 SMN2 10901626 712779 Immunolocalization studies using SMN monoclonal antibody showed that is decreased in cultures grown in low K+ or chemically defined medium with respect to cultures grown in high K+ medium and that an increase of [SMN] can be *induced* by treatment of low K+ cultures with glutamate or N-methyl-D-aspartate . Positive_regulation GEMIN2 SMN2 22607171 2625240 The SMN-Gemin2 structure explains how [Gemin2] is *stabilized* by and establishes a framework for structure-function studies to investigate snRNP biogenesis as well as biological processes involving Gemin2 that do not involve snRNP assembly . Positive_regulation GEMIN4 SMN2 10369862 621809 In SMA patients , the loss of SMN1 but the presence of *results* in low levels of full-length [SMN] transcript and therefore low SMN protein levels which causes SMA . Positive_regulation GEMIN4 SMN2 10500148 648017 Moreover , we show that [SMN] , but not mutants found in SMA patients , can form large oligomers and that oligomerization is *required* for high-affinity binding to spliceosomal snRNP Sm proteins . Positive_regulation GEMIN4 SMN2 10767334 684884 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Positive_regulation GEMIN4 SMN2 10901626 712813 Immunolocalization studies using SMN monoclonal antibody showed that [SMN] is decreased in cultures grown in low K+ or chemically defined medium with respect to cultures grown in high K+ medium and that an increase of can be *induced* by treatment of low K+ cultures with glutamate or N-methyl-D-aspartate . Positive_regulation GEMIN4 SYT8 16713576 1564905 induces a 4-fold *increase* in the ATPase activity of wild-type [p97/VCP] ( p97/VCP ( wt ) ) , but not in mutants that showed an ERAD impairment . Positive_regulation GEMIN5 SMN2 10369862 621810 In SMA patients , the loss of SMN1 but the presence of *results* in low levels of full-length [SMN] transcript and therefore low SMN protein levels which causes SMA . Positive_regulation GEMIN5 SMN2 10500148 648024 Moreover , we show that [SMN] , but not mutants found in SMA patients , can form large oligomers and that oligomerization is *required* for high-affinity binding to spliceosomal snRNP Sm proteins . Positive_regulation GEMIN5 SMN2 10767334 684894 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Positive_regulation GEMIN5 SMN2 10901626 712823 Immunolocalization studies using SMN monoclonal antibody showed that is decreased in cultures grown in low K+ or chemically defined medium with respect to cultures grown in high K+ medium and that an increase of [SMN] can be *induced* by treatment of low K+ cultures with glutamate or N-methyl-D-aspartate . Positive_regulation GEMIN6 SMN2 10369862 621811 In SMA patients , the loss of SMN1 but the presence of *results* in low levels of full-length [SMN] transcript and therefore low SMN protein levels which causes SMA . Positive_regulation GEMIN6 SMN2 10500148 648031 Moreover , we show that , but not mutants found in SMA patients , can form large oligomers and that [SMN] oligomerization is *required* for high-affinity binding to spliceosomal snRNP Sm proteins . Positive_regulation GEMIN6 SMN2 10901626 712833 Immunolocalization studies using SMN monoclonal antibody showed that is decreased in cultures grown in low K+ or chemically defined medium with respect to cultures grown in high K+ medium and that an increase of [SMN] can be *induced* by treatment of low K+ cultures with glutamate or N-methyl-D-aspartate . Positive_regulation GEMIN7 SMN2 10369862 621812 In SMA patients , the loss of SMN1 but the presence of *results* in low levels of full-length [SMN] transcript and therefore low SMN protein levels which causes SMA . Positive_regulation GEMIN7 SMN2 10500148 648036 Moreover , we show that , but not mutants found in SMA patients , can form large oligomers and that [SMN] oligomerization is *required* for high-affinity binding to spliceosomal snRNP Sm proteins . Positive_regulation GEMIN7 SMN2 10901626 712843 Immunolocalization studies using SMN monoclonal antibody showed that is decreased in cultures grown in low K+ or chemically defined medium with respect to cultures grown in high K+ medium and that an increase of [SMN] can be *induced* by treatment of low K+ cultures with glutamate or N-methyl-D-aspartate . Positive_regulation GEMIN8 SMN2 17023415 1647856 We show that Gemin6 , Gemin7 , and Unrip form a stable cytoplasmic complex whose association with *requires* [Gemin8] . Positive_regulation GFAP CAPN8 24383076 2882216 Connexin (Cx)-43 , [glial fibrillary acidic protein (GFAP)] , activated <µ-calpain> and a-fodrin breakdown product (FBP) *increased* post-injury , peaking at 1 h , in the injury and adjacent areas . Positive_regulation GFAP EPHB2 23506591 2756953 Curcumin reduced the injury induced thermal and mechanical hyperalgesia , the increase in the fluorescence intensity of GFAP and the hypertrophy of astrocytic soma , *activation* of [GFAP] and phosphorylation of in the spinal dorsal horn . Positive_regulation GFAP IL1B 19940926 2167648 Importantly , Nestin-Cre and [GFAP-Cre] rank ( floxed ) deleter mice are resistant to lipopolysaccharide induced fever as well as fever in *response* to the key inflammatory cytokines and TNFalpha . Positive_regulation GFAP ITGB2 18823368 1981534 The expression of increased 1 day after MDMA treatment and [glial fibrillary acidic protein] *increased* 3 days post-treatment in the striatum and SN but not in the NAc , in strict anatomical correlation with dopaminergic damage . Positive_regulation GFAP TNF 10674496 667520 We also demonstrate that *induced* over-expression of [GFAP] was significantly attenuated by the MAPK inhibitor PD98059 . Positive_regulation GFAP TNF 15668227 1388259 In primary astrocytes , stimulation increased the intracellular levels of lactosylceramide ( LacCer ) and *induced* [GFAP] expression and astrocyte proliferation . Positive_regulation GFAP TNF 15668227 1388267 Furthermore , *mediated* astrocyte proliferation and [GFAP] expression was also inhibited by LY294002 , a phosphatidylinositol 3-kinase inhibitor , which was reversed by exogenous LacCer . Positive_regulation GFAP TNF 7774879 308903 Furthermore the stimulation *increased* [glial fibrillary acidic protein] and production of bioactive molecules including interleukin(IL)-6 , IL-8 , granulocyte-macrophage colony stimulating factor , prostaglandin E2 and manganous superoxide dismutase . Positive_regulation GGA1 EPHB2 23792203 2820537 These findings suggest that *activation* of by [GGA] reduces melanin synthesis in Mel-Ab cells through downregulation of MITF and tyrosinase expression . Positive_regulation GGA2 EPHB2 23792203 2820535 These findings suggest that *activation* of by [GGA] reduces melanin synthesis in Mel-Ab cells through downregulation of MITF and tyrosinase expression . Positive_regulation GGA3 EPHB2 21664574 2442650 Met recycling , sustained activation , and migration *require* interaction of [GGA3] with Arf6 and an unexpected association with the Crk adaptor . Positive_regulation GGA3 EPHB2 23792203 2820536 These findings suggest that *activation* of by [GGA] reduces melanin synthesis in Mel-Ab cells through downregulation of MITF and tyrosinase expression . Positive_regulation GH1 EDN2 10479676 643464 Expression of Ca ( 2+ ) -mobilizing ( A ) receptors and their *role* in the control of Ca ( 2+ ) influx and [growth hormone] secretion in pituitary somatotrophs . Positive_regulation GH1 EPHB2 16109809 1474081 PKC and are differentially *involved* in gonadotropin releasing hormone induced [growth hormone] gene expression in the goldfish pituitary . Positive_regulation GH1 FOXO1 18997443 2041410 [Growth hormone] *increases* mRNA levels of PPARdelta and in skeletal muscle of growth hormone deficient lit/lit mice . Positive_regulation GH1 IL1B 2785989 113599 Interestingly , the ability of to *induce* human [growth hormone] expression decreased as the length of the promoter fragment was reduced . Positive_regulation GH1 IL1B 2821620 78608 Recombinant human *stimulated* the secretion of adrenocorticotropic hormone , luteinizing hormone , [growth hormone] , and thyroid stimulating hormone . Positive_regulation GHITM ITGAL 10023864 590798 Monoclonal antibody ( MoAb ) -blocking experiments showed that interaction was *essential* for MDDC stimulation of [Der p 2-specific] T-cell proliferative responses . Positive_regulation GHRH EPHB2 22307626 2552235 [GHRH] *induced* a significant increase in levels of , but JMR-132 abolished this outcome . Positive_regulation GHRH IL1B 12213318 985352 In this study , we found both [GHRH] ( 100 nM ) and ( 1.2 pM ) acutely *increased* cytosolic Ca ( 2+ ) in 7.6 and 4.0 % of cultured hypothalamic neurons tested , respectively , and 1.2 % of neurons responded to both . Positive_regulation GHRH IL1B 14763997 1207188 *stimulates* [growth hormone releasing hormone] receptor mRNA expression in the rat hypothalamus in vitro and in vivo . Positive_regulation GHRH IL1B 14763997 1207190 Up-regulation of hypothalamic GHRH-R by IL-1beta may explain previous findings suggesting that *stimulates* [GHRH] activity . Positive_regulation GHRHR IL1B 14763997 1207189 *stimulated* [GHRH-R] mRNA expression both in vitro ( 10 and 100 ng/ml ) and in vivo ( 2.5 and 25 ng ) . Positive_regulation GHRHR IL1B 14763997 1207191 *Up-regulation* of hypothalamic [GHRH-R] by may explain previous findings suggesting that IL-1beta stimulates GHRH activity . Positive_regulation GIF DAPK1 22465880 2588970 Both TNF-a and [INF-?] significantly *induce* levels in a time dependent manner . Positive_regulation GIF DAPK1 22465880 2588978 Taken together , our data findings suggest that can *mediate* the pro-apoptotic activity of TNF-a and [INF-?] via the NF-?B signaling pathways . Positive_regulation GIF TNF 15481863 1320392 [INF-gamma] *induced* dose dependent rises in the plasma levels of both cortisol and ACTH , while induced comparable plasma cortisol responses with much smaller rises in plasma ACTH . Positive_regulation GIF TNFSF10 17628186 1770232 alpha-TOS and in combination with dendritic cells *induce* [INF-gamma] production by CD4+ and CD8+ T lymphocytes , resulting in a significant tumor growth inhibition or in complete tumor regression . Positive_regulation GIP ARSA 7043491 20700 The *had* no significant effect on plasma glucagon or [gastric inhibitory polypeptide] in either group I or group II . Positive_regulation GJA1 CAPN8 24383076 2882231 [Connexin (Cx)-43] , glial fibrillary acidic protein (GFAP) , activated <µ-calpain> and a-fodrin breakdown product (FBP) *increased* post-injury , peaking at 1 h , in the injury and adjacent areas . Positive_regulation GJA1 CTGF 20117462 2202365 Rac1 induced *regulates* [connexin 43] and N-cadherin expression in atrial fibrillation . Positive_regulation GJA1 EPHB2 10792610 689332 Using two structurally unrelated PI3K inhibitors , wortmanin and LY294002 , both tyrosine phosphorylation of [Cx43] and *activation* of stimulated by PDGF were largely blocked . Positive_regulation GJA1 EPHB2 15652497 1364263 As a *consequence* of activation , [Cx43] was phosphorylated , resulting in a downregulation of GJC . Positive_regulation GJA1 EPHB2 23712704 2806463 Subsequently , extracellular signal regulated kinase ( ERK ) was inhibited with PD98059 to analyze the *role* of in modulating [CX43] expression after LPS preconditioning . Positive_regulation GJA1 F2R 21147226 2396186 In turn , the , PAR-1 , *regulates* the expression of the gap junction protein [Connexin-43] and the tumor suppressor gene Maspin . Positive_regulation GJA1 FAS 16005448 1452949 activation *increased* nuclei surface area , atrial natriuretic peptide and connexin43 (Cx43) mRNA , the protein levels of total [Cx43] and non phosphorylated Cx43 , and sarcomeric actin , all indicating hypertrophy . Positive_regulation GJA1 GJB2 10690907 670518 In both normal and neoplastic adrenal tissues , only alpha1 [connexin 43] could be *detected* , whereas beta1 connexin 32 and beta2 were not found . Positive_regulation GJA1 GJB2 21243523 2419653 Western blot analysis demonstrated expression of [connexin (Cx) 43] and 26 in control cells and reduced expression of Cx 43 but not protein from 0.1 to 1 mM CH. CH treatment from 2.5 to 5 mM *caused* an apparent increase in expression of both connexins that was concomitant with a reduction in mRNA expression for both connexins . Positive_regulation GJA1 IL1B 10976987 729622 *increases* the functional expression of [connexin 43] in articular chondrocytes : evidence for a Ca2+ dependent mechanism . Positive_regulation GJA1 IL1B 12082278 958512 The functional expression of [connexin 43] in articular chondrocytes is *increased* by : evidence for a Ca2+ dependent mechanism . Positive_regulation GJA1 MUC16 15690152 1416494 The ability of benzene metabolites to interfere with gap-junction functionality , and especially the dramatic loss of [Cx43] *induced* by , should therefore be considered as a possible mechanism for benzene induced hematotoxicity and development of leukemia . Positive_regulation GJA1 MUC16 15935824 1415078 The finding that benzene metabolites interfere with gap junction functionality , and especially the loss of [connexin 43] *induced* by , should be considered concerning the mechanism of benzene induced hematotoxicity . Positive_regulation GJA1 MUC16 18723040 1975041 We show that *induces* cross linking of the gap junction protein [connexin43] and that this is likely to be responsible for the induced inhibition of GJIC , as well as the loss of connexin43 observed in Western blots . Positive_regulation GJA1 TNF 12538692 1050251 plus IFN-gamma *induce* [connexin43] expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses . Positive_regulation GJA1 TNF 17690839 1842488 Here we show that *increases* the level of phosphorylated [Cx43] in primary astrocytes but not in the F98 glioma cells . Positive_regulation GJA1 TNF 19907029 2224826 The authors examined the role of the ubiquitin-proteasome system in the *induced* degradation of [Cx43] in these cells . Positive_regulation GJA1 TNF 24919967 2952173 also *increased* [connexin-43] expression and hemichannel activity , but not gap junction communication in astrocyte cultures prepared from cortices and spinal cords . Positive_regulation GJB1 GJB2 15558322 1361155 Recently , we found that Cx32 but not was closely related to tight junctional proteins in primary cultured rat hepatocytes ( Kojima et al. , Exp Cell Res 263 : 193-201 , 2001 ) and that [Cx32] formation and/or Cx32 mediated intercellular communication could *induce* expression and function of tight junctions in a mouse hepatic cell line ( Kojima et al. , Exp Cell Res 276 : 40-51 , 2002 ) . Positive_regulation GJB1 IL1B 15350541 1292416 *regulates* expression of [Cx32] , occludin , and claudin-2 of rat hepatocytes via distinct signal transduction pathways . Positive_regulation GJB2 BRMS1L 24260596 2869718 Furthermore , overexpression *up-regulated* [Cx26] expression , whereas Cx32 , Cx43 expressions did not changed . Positive_regulation GJB2 CDH1 11429787 831688 We also found that induction of and subsequent formation of a cell adhesion complex were *induced* in HepG2 cells by [Cx 26] expression . Positive_regulation GJB2 GJB1 15558322 1361156 Recently , we found that Cx32 but not [Cx26] was closely related to tight junctional proteins in primary cultured rat hepatocytes ( Kojima et al. , Exp Cell Res 263 : 193-201 , 2001 ) and that formation and/or Cx32 mediated intercellular communication could *induce* expression and function of tight junctions in a mouse hepatic cell line ( Kojima et al. , Exp Cell Res 276 : 40-51 , 2002 ) . Positive_regulation GJB2 MAPK8IP1 12064607 895200 [Connexin26] is *regulated* in rat urothelium by the scaffold protein . Positive_regulation GJB2 TJP1 11304795 803764 In the adult rat cochlear lateral wall , [Cx26] was *detected* in fibrocytes in the spiral ligament and in the basal cell layer of the stria vascularis , whereas was detected in the apical surfaces of marginal cells and in the basal cell layer . Positive_regulation GJB6 GJB2 20926451 2364709 In the inner ear , reduced intercellular coupling by heteromeric channels composed of Cx26S17F and Cx30 could contribute to hearing impairment in heterozygous mice , while remaining wild-type may be *sufficient* to stabilize [Cx30] and partially maintain cochlear homeostasis . Positive_regulation GLA MMP28 9054450 417352 [GL-A] activation is *mediated* by a membrane-type ( MT-MMP ) that cleaves the GL-A propeptide . Positive_regulation GLA MMP7 9054450 417367 [GL-A] activation is *mediated* by a membrane-type MMP ( ) that cleaves the GL-A propeptide . Positive_regulation GLB1 CCND1 18045963 1832932 In Y1 cells , AVP blocks expression , *induces* senescence associated [beta-galactosidase] ( SAbeta-Gal ) and inhibits proliferation . Positive_regulation GLB1 NES 10800092 691415 With the use of the two adenovirus vectors , we found X-gal staining and high regulator *promoted* [beta-galactosidase] activities in four of the seven glioma/glioblastoma cell lines . Positive_regulation GLB1 TNF 15326480 1296861 The present study described that , in the leukemic KG1 cells , *induced* no apoptosis but a senescence state characterized by prolonged growth arrest , increased [beta-galactosidase] activity , p21WAF-1 induction , decreased telomerase activity , telomeric disturbances ( shortening , losses , fusions ) , and additional chromosomal aberrations . Positive_regulation GLB1 TNF 7543732 314374 Although apigenin did not inhibit TNF-alpha induced nuclear translocation of NF-kappa B ( p50 ( NFKB1 ) /p65 ( RelA ) ) we found this flavonoid did inhibit *induced* [beta-galactosidase] activity in SW480 cells stably transfected with a beta-galactosidase reporter construct driven by four NF-kappa B elements , suggesting an action on NF-kappa B transcriptional activation . Positive_regulation GLB1 TNF 9877207 557284 The ERalpha was able to repress by 80 % the *mediated* expression of [beta-galactosidase] under the control of NREs in an E2-dependent manner in HeLa cells but not in HEK-293 cells . Positive_regulation GLG1 FUT4 11404363 842967 Interestingly , surface plasmon resonance experiments with recombinant ESL-1 from alpha 1,3-fucosyltransferase IV-expressing Chinese hamster ovary cells showed a very similar K ( d ) of 66 microm , suggesting that this is *sufficient* to produce fully functional recombinant [ESL-1] . Positive_regulation GLI1 MAP2K6 17392427 1720997 Finally , we provide evidence that endogenous and AKT signaling *regulate* the nuclear localization and transcriptional activity of [GLI1] in melanoma and other cancer cells . Positive_regulation GLI2 MAP2K6 23208494 2895391 MEK1 and RSK2 failed to augment the half-life of GLI2 lacking GSK-3ß phosphorylation sites , indicating that *stabilizes* [GLI2] by controlling targeting GSK-3ß mediated phosphorylation and ubiquitination of GLI2 . Positive_regulation GLO1 TNF 11792832 901960 *induced* modulation of [glyoxalase I] activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methylglyoxal derived AGE . Positive_regulation GLO1 TNF 11792832 901961 Furthermore , we provide evidence that the *induced* phosphorylation of [glyoxalase I] is not involved in detoxification of MG by means of the glyoxalase system , but that phosphorylated glyoxalase I is on the pathway leading to the formation of a specific MG-derived advanced glycation end product . Positive_regulation GLO1 TNF 17576200 1786137 We have previously shown that ( tumour necrosis factor ) *induces* phosphorylation of [GLO1] ( glyoxalase I ) , which is required for cell death in L929 cells . Positive_regulation GLO1 TNF 17576200 1786138 In the present paper , we show that the *induced* phosphorylation of [GLO1] occurs primarily on the NO ( nitric oxide ) -responsive form of GLO1 . Positive_regulation GLO1 TNF 17576200 1786139 In summary , these data suggest that the *induced* phosphorylation of [GLO1] is the dominant factor for cell death . Positive_regulation GLO1 TNF 19199007 2049726 By using this phospho-specific antibody , we demonstrated that *induces* phosphorylation of [GLO1] on Thr-106 . Positive_regulation GLP1R CAV1 24269940 2893106 Moreover , signaling was *involved* in PPARß/d regulated [GLP-1R] expression . Positive_regulation GLP1R DPP4 21484567 2417640 Incretin based therapies consist of two classes : ( 1 ) the injectable [GLP-1 receptor] agonists solely acting on the GLP-1 receptor and ( 2 ) dipeptidyl-peptidase *inhibitors* ( inhibitors ) as oral medications raising endogenous GLP-1 and other hormone levels by inhibiting the degrading enzyme DPP-4 . Positive_regulation GLP1R DPP4 22025647 2539983 The observed renoprotection is probably attributable to inhibition of activity , mimicking of incretin action , and *activation* of the [GLP-1R] . Positive_regulation GLP1R IL1A 24048027 2846350 [Glucagon-like peptide 1 receptor] induced suppression of food intake , and body weight is *mediated* by central and IL-6 . Positive_regulation GLP1R IL6 24048027 2846351 [Glucagon-like peptide 1 receptor] induced suppression of food intake , and body weight is *mediated* by central IL-1 and . Positive_regulation GLP1R INS 10830274 697345 Exendin-4 *induces* release through activation of the [GLP- 1 receptor] but is a much more potent insulinotropic agent than GLP-1 . Positive_regulation GLP1R INS 23990978 2836461 Exendin-4 binds and activates the [Glucagon-Like Peptide-1 Receptor] ( GLP-1R ) , thus *inducing* release . Positive_regulation GLP1R LEP 18078857 1847214 The promoter activity of [GLP-1R] in transfected GT1-7 cells *increased* with , whereas neuropeptide Y (NPY) did not modify it . Positive_regulation GLP1R LEPR 22249232 2705739 The physiological control of feeding behavior involves modulation of the intake inhibitory effects of gastrointestinal satiation signaling via endogenous hindbrain and [glucagon-like-peptide-1 receptor] ( GLP-1R ) *activation* . Positive_regulation GLP1R MAFA 21190012 2386050 Similar overexpression of *resulted* in increased Neurod1 , Nkx6-1 , Gck and [Glp1r] mRNAs and no change in insulin content but , importantly , acquisition of glucose-responsive insulin secretion . Positive_regulation GLP1R POMC 16423821 1495106 Co-transfection of the pIRES vector with the [GLP-1R] resulted in GLP-1 stimulated *activation* of promoter-driven preproinsulin gene transcription but insulin secretion was not detected . Positive_regulation GLP1R PRKCA 17360984 1741214 The reduction of [GLP-1 receptor] expression by high glucose was *prevented* by dominant negative overexpression , whereas GLP-1 receptor expression was reduced with wild-type PKCalpha overexpression . Positive_regulation GLP1R SP1 9927286 588491 Gene expression of the human [glucagon-like peptide-1 receptor] is *regulated* by and Sp3 . Positive_regulation GLP1R SP1 9927286 588496 Therefore , the basal activity of the [GLP-1 receptor] gene is *mediated* by two proximal binding sites , whereas a more distal site acts as a repressor . Positive_regulation GLP1R SP3 9927286 588492 Gene expression of the human [glucagon-like peptide-1 receptor] is *regulated* by Sp1 and . Positive_regulation GLP1R SREBF1 24269940 2893105 Moreover , signaling was *involved* in PPARß/d regulated [GLP-1R] expression . Positive_regulation GLP1R TYR 20799012 2313734 Replacing the original ( 1 ) and/or Ile ( 7 ) in the N-terminal moiety of this mutant peptide *allowed* full activation of GIPR but not of [GLP1R] . Positive_regulation GLP1R ZGLP1 17584962 1792346 [Glucagon-like peptide-1 (GLP-1) receptors] expressed on nerve terminals in the portal vein *mediate* the effects of endogenous on glucose tolerance in rats . Positive_regulation GLP1R ZGLP1 20498254 2301201 *activated* the [GLP-1 receptor] , was resistant to inactivation by peptidases , and had a half-life of approximately 2 days , compared with 1 to 2 min for native GLP-1 . Positive_regulation GLP1R ZGLP1 20805279 2313827 Common genetic variation in [GLP1R] and insulin secretion in *response* to exogenous in nondiabetic subjects : a pilot study . Positive_regulation GLP1R ZGLP1 21744074 2490061 The [GLP-1 receptor] was expressed on iNKT cells , and *induced* a dose dependent inhibition of iNKT cell cytokine secretion , but not cytolytic degranulation in vitro . Positive_regulation GLP1R ZGLP1 22207759 2558897 and liraglutide *activate* the [GLP-1R] , thereby promoting pre-adipocyte proliferation and inhibition of apoptosis . Positive_regulation GLP1R ZGLP1 22650224 2610558 These beneficial effects of on cardiac function are *mediated* by both [GLP-1 receptor] activation and GLP-1 receptor independent actions . Positive_regulation GLP1R ZGLP1 22749990 2644447 Unlike the glucose lowering effect of GLP-1 ( 7-37 ) , the glucose lowering effect of GLP-1 ( 1-37 ) could not be blocked by the GLP-1R antagonist exendin ( 9-39 ) , suggesting that ( 1-37 ) might *activate* the [GLP-1R] via a different mechanism . Positive_regulation GLP1R ZGLP1 23986202 2866438 Insulin/exendin-4 also significantly stimulate acute and long-term GLP-1 secretion in the presence of glucose , suggesting novel beneficial effects of insulin signaling and [GLP-1R] *activation* on glycemia through enhanced mass of GLP-1 producing cells and enhanced secretion . Positive_regulation GLP1R ZGLP1 24307763 2877770 The biological effects of are *mediated* by its specific receptor [GLP-1R] that is expressed in a wide range of tissues , where it is responsible of the extra-pancreatic effects of GLP-1 . Positive_regulation GLP1R ZGLP1 24307763 2877771 Then , the activation postreceptor intracellular signal transduction pathways ( extracellular signal regulated kinases 1 and 2 [ ERK1/2 ] and protein kinase B [ PKB ] ) were assessed by western blot in normal cells or silenced for [GLP-1R] in the *presence* or absence of 10 nmol/L . Positive_regulation GLRX IL1B 19490803 2091318 *induced* reactive oxygen species ( ROS ) formation and [GRX-1] expression in the airway epithelial cells was determined by flow cytometry and immunoassay . Positive_regulation GLRX IL1B 19490803 2091319 *increased* the intracellular ROS formation and [GRX-1] expression in airway epithelial cells . Positive_regulation GLRX IL1B 19490803 2091320 Diphenyleneiodonium and apocynin , NADPH oxidase inhibitors , did not abolish *induced* ROS formation and [GRX-1] expression , whereas budesonide attenuated it . Positive_regulation GLRX IL1B 19490803 2091321 *induced* up-regulation of [GRX-1] in airway epithelial cells is probably mediated by ROS . Positive_regulation GLRX IL1B 19490803 2091322 Glucocorticoids can regulate *induced* ROS formation and [GRX-1] expression . Positive_regulation GLS IL1B 11732857 885243 *induced* expression of matrix metalloproteinases and gliostatin/platelet derived endothelial cell growth factor ( [GLS/PD-ECGF] ) in a chondrosarcoma cell line ( OUMS-27 ) . Positive_regulation GLS TNF 22534375 2669163 significantly *increased* [GLS] expression in RA FLSs ; Positive_regulation GLS TNF 9133962 427360 In cultured fibroblast-like synoviocytes , , IL-1 , IL-6 and IL-8 *induced* [GLS] expression . Positive_regulation GLUL FOXO1 25074987 2956774 *activates* [glutamine synthetase] gene in mouse skeletal muscles through a region downstream of 3'-UTR : possible contribution to ammonia detoxification . Positive_regulation GLUL S100B 21974860 2497851 Total reactive antioxidant potential ( TRAP ) , superoxide dismutase (SOD) activity , and glial fibrilary acid protein (GFAP) content did not change , but caloric restriction was able to *increase* [glutamine synthetase (GS)] activity in RS and glutamate uptake in RS and RE . Positive_regulation GMIP IL1B 11129085 759946 ( 100 IU/mL ) , which induces iNOS in SMC from both control and atherosclerotic aortas *causes* accumulation of cyclic [GMIP] in the extracellular medium between 3 and 6 h for control SMC and between 3 and 24 h with atherosclerotic SMC . Positive_regulation GMPR QRICH1 6249786 11555 It is postulated that glutamine or a product of its metabolism may function under normal conditions as a negative regulatory element in the control of [guanosine monophosphate reductase] and that decreased effective intracellular levels of *result* in an increase in the level of the enzyme . Positive_regulation GMPR QRICH2 6249786 11556 It is postulated that glutamine or a product of its metabolism may function under normal conditions as a negative regulatory element in the control of [guanosine monophosphate reductase] and that decreased effective intracellular levels of *result* in an increase in the level of the enzyme . Positive_regulation GNA12 EDN2 17878759 1797096 Selective *activation* of human atrial [Galpha12] and Galpha13 by Galphaq coupled angiotensin and receptors . Positive_regulation GNA12 EDN2 17878759 1797102 receptors *activate* only Galpha12 ( to 218 +/- 22 % of unstimulated levels ) , angiotensin receptors activate only Galpha13 ( to 236 +/- 49 % of unstimulated levels ) , and alpha1-adrenergic receptors activate neither [Galpha12] ( 123 +/- 18 % of unstimulated levels ) nor Galpha13 ( 113 +/- 12 % of unstimulated levels ) . Positive_regulation GNA12 TNF 10926555 718856 We have shown previously that *upregulates* the expression of [Galpha(i-2)] protein without significantly increasing G ( s ) alpha protein and enhances adenylyl cyclase inhibition by carbachol in cultured human airway smooth muscle cells ( Hotta K , Emala CW , and Hirshman CA. Am J Physiol Lung Cell Mol Physiol 276 : L405-L411 , 1999 ) . Positive_regulation GNA13 EDN2 10199825 605370 receptors *activate* [Galpha13] . Positive_regulation GNA13 EDN2 17878759 1797099 Selective *activation* of human atrial Galpha12 and [Galpha13] by Galphaq coupled angiotensin and receptors . Positive_regulation GNA13 EDN2 17878759 1797105 receptors *activate* only Galpha12 ( to 218 +/- 22 % of unstimulated levels ) , angiotensin receptors activate only Galpha13 ( to 236 +/- 49 % of unstimulated levels ) , and alpha1-adrenergic receptors activate neither Galpha12 ( 123 +/- 18 % of unstimulated levels ) nor [Galpha13] ( 113 +/- 12 % of unstimulated levels ) . Positive_regulation GNAS ADRB2 10931851 743825 Surprisingly , however , [XLalphas] , in contrast to Galphas , was not *activated* by the upon reconstitution of S49cyc ( - ) membranes . Positive_regulation GNAS EPHB2 12902401 1121108 LPA induced chemotaxis is markedly dependent on activation of PTX-sensitive [heterotrimeric G-proteins] , on activation of the small GTPases Ras , Rac and RhoA , and on GTPase dependent *activation* of . Positive_regulation GNAS GPR115 12426323 1025570 In contrast to *mediated* activation of [heterotrimeric G-proteins] in DDT ( 1 ) -MF-2 cell membrane preparations , the action of the NG-GPA was not altered by treatment of the cells with pertussis toxin . Positive_regulation GNAS GPR132 12426323 1025559 In contrast to *mediated* activation of [heterotrimeric G-proteins] in DDT ( 1 ) -MF-2 cell membrane preparations , the action of the NG-GPA was not altered by treatment of the cells with pertussis toxin . Positive_regulation GNAS GPR87 12426323 1025639 In contrast to *mediated* activation of [heterotrimeric G-proteins] in DDT ( 1 ) -MF-2 cell membrane preparations , the action of the NG-GPA was not altered by treatment of the cells with pertussis toxin . Positive_regulation GNAT1 RGS16 9211888 441940 The GTPase activity of [transducin] and the PDE inactivation rates in native ROS membranes in the *presence* of were elevated 3-fold or more regardless of the membrane concentrations . Positive_regulation GNAT1 TNF 7884323 299001 *stimulates* increased plasma membrane [guanine nucleotide binding protein] activity in polymorphonuclear leukocytes . Positive_regulation GNAT2 TNF 7884323 299002 *stimulates* increased plasma membrane [guanine nucleotide binding protein] activity in polymorphonuclear leukocytes . Positive_regulation GNAT3 TNF 7884323 299000 *stimulates* increased plasma membrane [guanine nucleotide binding protein] activity in polymorphonuclear leukocytes . Positive_regulation GNB1 EPHB2 12902401 1121112 LPA induced chemotaxis is markedly dependent on activation of PTX-sensitive [heterotrimeric G-proteins] , on activation of the small GTPases Ras , Rac and RhoA , and on GTPase dependent *activation* of . Positive_regulation GNB1 GPR115 12426323 1025663 In contrast to *mediated* activation of [heterotrimeric G-proteins] in DDT ( 1 ) -MF-2 cell membrane preparations , the action of the NG-GPA was not altered by treatment of the cells with pertussis toxin . Positive_regulation GNB1 GPR115 16129667 1474465 *Activation* of a [heterotrimeric G-protein] by an agonist stimulated requires the propagation of structural signals from the receptor binding interface to the guanine nucleotide binding pocket of the G-protein . Positive_regulation GNB1 GPR115 16979691 1640189 [Heterotrimeric G-protein] *activation* by an agonist stimulated requires the propagation of structural signals from the receptor interacting surfaces to the guanine nucleotide binding pocket . Positive_regulation GNB1 GPR115 17059215 1636937 [Heterotrimeric G-protein] *activation* by a requires the propagation of structural signals from the receptor interacting surfaces to the guanine nucleotide binding pocket . Positive_regulation GNB1 GPR132 12426323 1025652 In contrast to *mediated* activation of [heterotrimeric G-proteins] in DDT ( 1 ) -MF-2 cell membrane preparations , the action of the NG-GPA was not altered by treatment of the cells with pertussis toxin . Positive_regulation GNB1 GPR132 16129667 1474454 *Activation* of a [heterotrimeric G-protein] by an agonist stimulated requires the propagation of structural signals from the receptor binding interface to the guanine nucleotide binding pocket of the G-protein . Positive_regulation GNB1 GPR132 16979691 1640178 [Heterotrimeric G-protein] *activation* by an agonist stimulated requires the propagation of structural signals from the receptor interacting surfaces to the guanine nucleotide binding pocket . Positive_regulation GNB1 GPR132 17059215 1636926 [Heterotrimeric G-protein] *activation* by a requires the propagation of structural signals from the receptor interacting surfaces to the guanine nucleotide binding pocket . Positive_regulation GNB1 GPR87 12426323 1025732 In contrast to *mediated* activation of [heterotrimeric G-proteins] in DDT ( 1 ) -MF-2 cell membrane preparations , the action of the NG-GPA was not altered by treatment of the cells with pertussis toxin . Positive_regulation GNB1 GPR87 16129667 1474534 *Activation* of a [heterotrimeric G-protein] by an agonist stimulated requires the propagation of structural signals from the receptor binding interface to the guanine nucleotide binding pocket of the G-protein . Positive_regulation GNB1 GPR87 16979691 1640258 [Heterotrimeric G-protein] *activation* by an agonist stimulated requires the propagation of structural signals from the receptor interacting surfaces to the guanine nucleotide binding pocket . Positive_regulation GNB1 GPR87 17059215 1637006 [Heterotrimeric G-protein] *activation* by a requires the propagation of structural signals from the receptor interacting surfaces to the guanine nucleotide binding pocket . Positive_regulation GNB1 RGS16 9211888 441941 The GTPase activity of [transducin] and the PDE inactivation rates in native ROS membranes in the *presence* of were elevated 3-fold or more regardless of the membrane concentrations . Positive_regulation GNB2L1 IL1B 9298128 453275 Neither , nor IGF *had* an effect on PKC or [RACK1] expression . Positive_regulation GNB2L1 TNF 20080539 2205769 In mammalian cells , *causes* endogenous EED to translocate from the nucleus and to colocalize and physically interact with both endogenous nSMase2 and [RACK1] . Positive_regulation GNG2 EPHB2 12902401 1121116 LPA induced chemotaxis is markedly dependent on activation of PTX-sensitive [heterotrimeric G-proteins] , on activation of the small GTPases Ras , Rac and RhoA , and on GTPase dependent *activation* of . Positive_regulation GNG2 GPR115 12426323 1025756 In contrast to *mediated* activation of [heterotrimeric G-proteins] in DDT ( 1 ) -MF-2 cell membrane preparations , the action of the NG-GPA was not altered by treatment of the cells with pertussis toxin . Positive_regulation GNG2 GPR115 16129667 1474558 *Activation* of a [heterotrimeric G-protein] by an agonist stimulated requires the propagation of structural signals from the receptor binding interface to the guanine nucleotide binding pocket of the G-protein . Positive_regulation GNG2 GPR115 16979691 1640282 [Heterotrimeric G-protein] *activation* by an agonist stimulated requires the propagation of structural signals from the receptor interacting surfaces to the guanine nucleotide binding pocket . Positive_regulation GNG2 GPR115 17059215 1637030 [Heterotrimeric G-protein] *activation* by a requires the propagation of structural signals from the receptor interacting surfaces to the guanine nucleotide binding pocket . Positive_regulation GNG2 GPR132 12426323 1025745 In contrast to *mediated* activation of [heterotrimeric G-proteins] in DDT ( 1 ) -MF-2 cell membrane preparations , the action of the NG-GPA was not altered by treatment of the cells with pertussis toxin . Positive_regulation GNG2 GPR132 16129667 1474547 *Activation* of a [heterotrimeric G-protein] by an agonist stimulated requires the propagation of structural signals from the receptor binding interface to the guanine nucleotide binding pocket of the G-protein . Positive_regulation GNG2 GPR132 16979691 1640271 [Heterotrimeric G-protein] *activation* by an agonist stimulated requires the propagation of structural signals from the receptor interacting surfaces to the guanine nucleotide binding pocket . Positive_regulation GNG2 GPR132 17059215 1637019 [Heterotrimeric G-protein] *activation* by a requires the propagation of structural signals from the receptor interacting surfaces to the guanine nucleotide binding pocket . Positive_regulation GNG2 GPR87 12426323 1025825 In contrast to *mediated* activation of [heterotrimeric G-proteins] in DDT ( 1 ) -MF-2 cell membrane preparations , the action of the NG-GPA was not altered by treatment of the cells with pertussis toxin . Positive_regulation GNG2 GPR87 16129667 1474627 *Activation* of a [heterotrimeric G-protein] by an agonist stimulated requires the propagation of structural signals from the receptor binding interface to the guanine nucleotide binding pocket of the G-protein . Positive_regulation GNG2 GPR87 16979691 1640351 [Heterotrimeric G-protein] *activation* by an agonist stimulated requires the propagation of structural signals from the receptor interacting surfaces to the guanine nucleotide binding pocket . Positive_regulation GNG2 GPR87 17059215 1637099 [Heterotrimeric G-protein] *activation* by a requires the propagation of structural signals from the receptor interacting surfaces to the guanine nucleotide binding pocket . Positive_regulation GNGT1 RGS16 9211888 441942 The GTPase activity of [transducin] and the PDE inactivation rates in native ROS membranes in the *presence* of were elevated 3-fold or more regardless of the membrane concentrations . Positive_regulation GNGT2 RGS16 9211888 441943 The GTPase activity of [transducin] and the PDE inactivation rates in native ROS membranes in the *presence* of were elevated 3-fold or more regardless of the membrane concentrations . Positive_regulation GNRH1 AXIN2 19131506 2037544 Overexpression of , an inhibitor of beta-catenin , also *reduces* [GnRH] stimulation of TOPflash . Positive_regulation GNRH1 EPHB2 10194763 603908 We suggest that [GnRH] regulation of the GnRHR gene is partially *mediated* by an dependent activation of a canonical AP-1 site located in the proximal promoter of the GnRHR gene . Positive_regulation GNRH1 EPHB2 10799494 691177 Therefore , although *activation* of by [GnRH] requires a specific influx of calcium through L-type calcium channels , JNK activation is independent of extracellular calcium but sensitive to chelation of intracellular calcium . Positive_regulation GNRH1 EPHB2 11083862 809968 Role of dynamin , Src , and Ras in the protein kinase C-mediated *activation* of by [gonadotropin releasing hormone] . Positive_regulation GNRH1 EPHB2 11083862 809971 Our results suggest that the *activation* of by [GnRH] involves two distinct signaling pathways , which converge at the level of Raf-1 . Positive_regulation GNRH1 EPHB2 11750725 889864 *Activation* of -- one of the MAPK cascades -- by [GnRH] in these cells depends mainly on the phosphorylation of Raf1 by PKC , supported by a pathway involving c-Src , dynamin , and Ras . Positive_regulation GNRH1 EPHB2 11861527 917308 We conclude that and JNK are *involved* in basal and [GnRH-A] stimulation of LHbeta-CAT activity . Positive_regulation GNRH1 EPHB2 11875099 918870 Phosphorylation of both ERK and p38MAPK are stimulated rapidly , 30- to 50-fold in 5 min , but activation of c-Jun N-terminal kinase has slower kinetics , reaching only 10-fold after 30 min. *Activation* of by [GnRH] is blocked by inhibition of MAPK kinase ( MEK ) and partially blocked by inhibition of PKC and calcium , but not PI3K or p38MAPK signaling . Positive_regulation GNRH1 EPHB2 12538624 1050200 Thus , and c-Src but not JNK are *involved* in basal and [GnRH-A-stimulated-alphaCAT] , whereas c-Src contribution is independent of ERK activation . Positive_regulation GNRH1 EPHB2 14736735 1226077 Thus , PKC , , JNK , p38 , and c-Src , but not Ca ( 2+ ) , are *involved* in [GnRH] induction of the ovine FSHbeta gene . Positive_regulation GNRH1 EPHB2 15878957 1432937 Adenoviral expression of a kinase-inactive , dominant negative version of PKCdelta impaired [GnRH] *activation* of , but not induction of c-Fos and LHbeta proteins , indicating that the novel PKCs signal to the ERK cascade . Positive_regulation GNRH1 EPHB2 18801931 1981186 We show that in Galpha ( q/11 ) -negative cells stably expressing the GnRH receptor , [GnRH] did not *induce* activation of , jun-N-terminal kinase , or P38 MAPK . Positive_regulation GNRH1 EPHB2 18801931 1981212 In contrast to Galpha ( i ) or chimeric Galpha ( qi5 ) , transfection of Galpha ( q ) cDNA enabled [GnRH] to *induce* phosphorylation of , jun-N-terminal kinase , and P38 . Positive_regulation GNRH1 EPHB2 23880664 2849560 Moreover , kisspeptin stimulated MAPKs and AKT signaling , and signaling was functionally *involved* in the kisspeptin induced [GnRH] expression . Positive_regulation GNRH1 GPR115 18005407 1835840 Kisspeptins and their , GPR54 are *required* for [GnRH] release and have been associated with anti-metastatic tumour cell behaviour in model systems . Positive_regulation GNRH1 GPR132 18005407 1835829 Kisspeptins and their , GPR54 are *required* for [GnRH] release and have been associated with anti-metastatic tumour cell behaviour in model systems . Positive_regulation GNRH1 GPR87 18005407 1835909 Kisspeptins and their , GPR54 are *required* for [GnRH] release and have been associated with anti-metastatic tumour cell behaviour in model systems . Positive_regulation GNRH1 IL1B 12568852 1057187 Recombinant IL-1 receptor antagonist and anti-IL-1beta antibody attenuated the increase of gene expression of [GnRH] *initiated* by . Positive_regulation GNRH1 IL1B 2239094 144720 and tumour necrosis factor alpha *stimulate* the release of [gonadotropin releasing hormone] and interleukin 6 by primary cultured rat hypothalamic cells . Positive_regulation GNRH1 IL1B 2239094 144723 The abilities of recombinant human and tumour necrosis factor alpha to *induce* release of [GnRH] and interleukin 6 from primary culture of rat hypothalamic cells were examined . Positive_regulation GNRH1 IL1B 2239094 144725 Both and tumour necrosis factor alpha *caused* significant stimulation of [GnRH] secretion from the hypothalamic cells within 5 min . Positive_regulation GNRH1 IL1B 2239094 144726 These results suggest that and tumour necrosis factor alpha *stimulate* the secretions of [GnRH] and interleukin 6 in the hypothalamus , and that these cytokines may be involved in the mechanism of GnRH secretion in the hypothalamus . Positive_regulation GNRH1 MSX1 15743757 1403122 These findings strongly support a *role* for and DLX in contributing to spatiotemporal regulation of [GnRH] transcription during development . Positive_regulation GNRH1 PLAT 3114254 77525 [GnRH] *induced* secretion by cultured rat granulosa cells , but inhibited the secretion of urokinase-type PA . Positive_regulation GNRH1 SELL 1916215 168243 LHRH , [ D-Ala6 ] [LHRH] , [ Ala4 ] LHRH , <[Leu8> ] LHRH , and [ Phe5 ] LHRH *increased* plasma LH at 50-500 ng . Positive_regulation GNRH2 CA12 15862567 1400964 Using Ca(i)2+ imaging and the calcium-sensitive dye fura-2 , we found that chicken [GnRH-II] ( cGnRH-II ) *induced* a rapid dose dependent increase in in dispersed tilapia lactotrophs . Positive_regulation GNRH2 EPHB2 11083862 809969 Role of dynamin , Src , and Ras in the protein kinase C-mediated *activation* of by [gonadotropin releasing hormone] . Positive_regulation GNRH2 IL1B 2239094 144721 and tumour necrosis factor alpha *stimulate* the release of [gonadotropin releasing hormone] and interleukin 6 by primary cultured rat hypothalamic cells . Positive_regulation GNRHR EPHB2 10194763 603909 We suggest that GnRH regulation of the [GnRHR] gene is partially *mediated* by an dependent activation of a canonical AP-1 site located in the proximal promoter of the GnRHR gene . Positive_regulation GNRHR EPHB2 18801931 1981214 We therefore provide direct evidence , in multiple cellular backgrounds , that coupling of the [GnRH receptor] to Galpha ( q/11 ) , but not to Galpha ( i/o ) or Galpha ( s ) , and consequent *activation* of plays a crucial role in GnRH mediated cell death . Positive_regulation GOT2 FOXA1 23318274 2746702 The human liver [fatty acid binding protein] ( FABP1 ) gene is *activated* by and PPARa ; Positive_regulation GP1BA CAPN8 20060803 2211999 The *role* of in the regulation of ADAM17 dependent [GPIbalpha] ectodomain shedding . Positive_regulation GP1BA CAPN8 9268316 449838 In contrast , activation in vWf stimulated platelets *required* ligand binding to both [GP Ib-V-IX] and integrin alphaIIbbeta3 . Positive_regulation GP1BA F2R 14521606 1147995 Globally , immunoprecipitation experiments and analysis of the cytoskeleton confirmed that [GPIb] translocation is powered by a contractile mechanism involving Ca2+ mobilization , actin polymerization , and myosin incorporation into the cytoskeleton and that both and PAR-4 can *activate* this process . Positive_regulation GP1BA F2R 8608229 352695 The experiments with TRAP showed that activation of the seven-transmembrane domain can *result* in translocation of [GPIb] , GPIX , and GPV to the SCCS independently of the GPIb mediated pathway of thrombin induced platelet activation . Positive_regulation GP1BA PECAM1 12893757 1157312 negatively *regulates* [GPIb/V/IX] signaling in murine platelets . Positive_regulation GP1BA TNF 1611082 191042 [GpIb alpha] mRNA *induction* by is detectable as early as 2 hours after exposure to this cytokine , and reaches a maximal level after 20 to 24 hours . Positive_regulation GP1BB CAPN8 9268316 449852 In contrast , activation in vWf stimulated platelets *required* ligand binding to both [GP Ib-V-IX] and integrin alphaIIbbeta3 . Positive_regulation GP1BB F2R 14521606 1147997 Globally , immunoprecipitation experiments and analysis of the cytoskeleton confirmed that [GPIb] translocation is powered by a contractile mechanism involving Ca2+ mobilization , actin polymerization , and myosin incorporation into the cytoskeleton and that both and PAR-4 can *activate* this process . Positive_regulation GP1BB F2R 8608229 352696 The experiments with TRAP showed that activation of the seven-transmembrane domain can *result* in translocation of [GPIb] , GPIX , and GPV to the SCCS independently of the GPIb mediated pathway of thrombin induced platelet activation . Positive_regulation GP1BB PECAM1 12893757 1157313 negatively *regulates* [GPIb/V/IX] signaling in murine platelets . Positive_regulation GP2 CAPN8 9369069 463951 Investigation of the mechanisms involved in shear dependent microparticle generation showed that binding of von Willebrand factor to platelet [glycoprotein] Ib , influx of extracellular calcium , and *activation* of platelet were required to generate microparticles under high shear stress conditions . Positive_regulation GP2 EDN2 8476633 218516 In mucosal explant cultures , ET-1 and *stimulated* lactoferrin and mucous [glycoprotein] release from serous and mucous cells , but ET-3 was inactive . Positive_regulation GP2 IL1B 11052809 743454 Fibronectin (FN) , a matrix [glycoprotein] highly expressed in injured tissues , can *induce* expression of in human blood monocytic cells . Positive_regulation GP2 IL1B 8053940 267841 Endotoxin ( LPS ) and *increased* the expression of tissue factor , a membrane anchored [glycoprotein] that initiates blood coagulation on the surface of cultured human umbilical vein endothelial cells ( HUVEC ) and human monocyte/macrophages . Positive_regulation GP2 IL1B 8102337 225865 Endotoxin ( LPS ) , and tumor necrosis factor-alpha (TNF) *increased* the expression of tissue factor , a membrane anchored [glycoprotein] that initiates blood coagulation on the surface of cultured bovine aortic endothelial cells ( ABAE ) and human monocytes . Positive_regulation GP2 IL1B 8815590 366047 Endotoxin ( LPS ) and *increased* in a dose dependent manner the expression of tissue factor , an ubiquitous membrane anchored [glycoprotein] that initiates blood coagulation at the surface of human umbilical vein endothelial cells ( HUVEC and human peripheral blood mononuclear cells ( PBMC ) . Positive_regulation GP2 ITGB2 3539226 69229 Polymorphic [glycoprotein-1] on mouse platelets : possible *role* of Pgp-1 and in antibody dependent platelet cytotoxicity involving complement . Positive_regulation GP2 SPHK1 24385389 2906776 Sphingosine also reduced [P-glycoprotein] transport activity and those effects were *blocked* by an inhibitor of and by the S1PR1 antagonist . Positive_regulation GP2 TNF 1324245 194990 Macrophage membrane [glycoprotein] binding of Griffonia simplicifolia I-B4 *induces* production and a tumoricidal response . Positive_regulation GP2 TNF 15659313 1364877 *Role* of in down-regulation of hepatic cytochrome P450 and [P-glycoprotein] by endotoxin . Positive_regulation GP2 TNF 15659313 1364889 We investigated the *role* of in the down-regulation of hepatic [P-glycoprotein] and cytochrome P450 ( CYP ) by endotoxin , using TNF-alpha gene-deficient (TNF-alpha-/-) mice . Positive_regulation GP2 TNF 17132686 1693459 signaled through TNF-R1 , which in turn caused ET release and action through ETA and ETB receptors , nitric-oxide synthase , protein kinase C and nuclear factor-kappaB (NF-kappaB) and finally *increased* [P-glycoprotein] expression and transport activity . Positive_regulation GP2 TNF 17982267 1821203 *activates* [P-glycoprotein] in cerebral microvascular endothelial cells . Positive_regulation GP2 TNF 7907642 250429 Furthermore , recombinant *had* no effect on the induction of P [glycoprotein] expression in U1 cells . Positive_regulation GP2 TNF 8102337 225864 Endotoxin ( LPS ) , interleukin-1 beta (IL-1) and *increased* the expression of tissue factor , a membrane anchored [glycoprotein] that initiates blood coagulation on the surface of cultured bovine aortic endothelial cells ( ABAE ) and human monocytes . Positive_regulation GP2 TNF 8968260 402470 To test the hypothesis that after cecal ligation and puncture in the rat , there is increased expression of the *dependent* , acute-phase reactant alpha 1-acid [glycoprotein] in the liver , and that this change correlates temporally with increased abundance of TNF-alpha in the hepatic parenchyma but not with circulating concentrations of TNF-alpha . Positive_regulation GP5 CAPN8 9369069 463965 Investigation of the mechanisms involved in shear dependent microparticle generation showed that binding of von Willebrand factor to platelet [glycoprotein] Ib , influx of extracellular calcium , and *activation* of platelet were required to generate microparticles under high shear stress conditions . Positive_regulation GP5 EDN2 8476633 218518 In mucosal explant cultures , ET-1 and *stimulated* lactoferrin and mucous [glycoprotein] release from serous and mucous cells , but ET-3 was inactive . Positive_regulation GP5 F2R 8608229 352690 While confirming that both thrombin and neutrophil elastase proteolyse GPV , we show that neutrophil cathepsin G , activating peptide ( TRAP ) , and a combination of ADP and epinephrine can each *result* in a decrease in the platelet surface expression of [GPV] by a nonproteolytic mechanism : a cytoskeletal mediated redistribution of platelet surface GPV to the surface connected canalicular system ( SCCS ) . Positive_regulation GP5 F2R 8608229 352697 The experiments with TRAP showed that activation of the seven-transmembrane domain can *result* in translocation of GPIb , GPIX , and [GPV] to the SCCS independently of the GPIb mediated pathway of thrombin induced platelet activation . Positive_regulation GP5 IL1B 11052809 743455 Fibronectin (FN) , a matrix [glycoprotein] highly expressed in injured tissues , can *induce* expression of in human blood monocytic cells . Positive_regulation GP5 IL1B 8053940 267842 Endotoxin ( LPS ) and *increased* the expression of tissue factor , a membrane anchored [glycoprotein] that initiates blood coagulation on the surface of cultured human umbilical vein endothelial cells ( HUVEC ) and human monocyte/macrophages . Positive_regulation GP5 IL1B 8102337 225867 Endotoxin ( LPS ) , and tumor necrosis factor-alpha (TNF) *increased* the expression of tissue factor , a membrane anchored [glycoprotein] that initiates blood coagulation on the surface of cultured bovine aortic endothelial cells ( ABAE ) and human monocytes . Positive_regulation GP5 IL1B 8815590 366048 Endotoxin ( LPS ) and *increased* in a dose dependent manner the expression of tissue factor , an ubiquitous membrane anchored [glycoprotein] that initiates blood coagulation at the surface of human umbilical vein endothelial cells ( HUVEC and human peripheral blood mononuclear cells ( PBMC ) . Positive_regulation GP5 ITGB2 3539226 69231 Polymorphic [glycoprotein-1] on mouse platelets : possible *role* of Pgp-1 and in antibody dependent platelet cytotoxicity involving complement . Positive_regulation GP5 SPHK1 24385389 2906778 Sphingosine also reduced [P-glycoprotein] transport activity and those effects were *blocked* by an inhibitor of and by the S1PR1 antagonist . Positive_regulation GP5 TNF 1324245 194991 Macrophage membrane [glycoprotein] binding of Griffonia simplicifolia I-B4 *induces* production and a tumoricidal response . Positive_regulation GP5 TNF 15659313 1364878 *Role* of in down-regulation of hepatic cytochrome P450 and [P-glycoprotein] by endotoxin . Positive_regulation GP5 TNF 15659313 1364890 We investigated the *role* of in the down-regulation of hepatic [P-glycoprotein] and cytochrome P450 ( CYP ) by endotoxin , using TNF-alpha gene-deficient (TNF-alpha-/-) mice . Positive_regulation GP5 TNF 17132686 1693460 signaled through TNF-R1 , which in turn caused ET release and action through ETA and ETB receptors , nitric-oxide synthase , protein kinase C and nuclear factor-kappaB (NF-kappaB) and finally *increased* [P-glycoprotein] expression and transport activity . Positive_regulation GP5 TNF 17982267 1821204 *activates* [P-glycoprotein] in cerebral microvascular endothelial cells . Positive_regulation GP5 TNF 7907642 250430 Furthermore , recombinant *had* no effect on the induction of P [glycoprotein] expression in U1 cells . Positive_regulation GP5 TNF 8102337 225866 Endotoxin ( LPS ) , interleukin-1 beta (IL-1) and *increased* the expression of tissue factor , a membrane anchored [glycoprotein] that initiates blood coagulation on the surface of cultured bovine aortic endothelial cells ( ABAE ) and human monocytes . Positive_regulation GP5 TNF 8968260 402498 To test the hypothesis that after cecal ligation and puncture in the rat , there is increased expression of the *dependent* , acute-phase reactant alpha 1-acid [glycoprotein] in the liver , and that this change correlates temporally with increased abundance of TNF-alpha in the hepatic parenchyma but not with circulating concentrations of TNF-alpha . Positive_regulation GP6 CAPN8 9369069 463937 Investigation of the mechanisms involved in shear dependent microparticle generation showed that binding of von Willebrand factor to platelet [glycoprotein] Ib , influx of extracellular calcium , and *activation* of platelet were required to generate microparticles under high shear stress conditions . Positive_regulation GP6 EDN2 8476633 218514 In mucosal explant cultures , ET-1 and *stimulated* lactoferrin and mucous [glycoprotein] release from serous and mucous cells , but ET-3 was inactive . Positive_regulation GP6 IL1B 11052809 743453 Fibronectin (FN) , a matrix [glycoprotein] highly expressed in injured tissues , can *induce* expression of in human blood monocytic cells . Positive_regulation GP6 IL1B 8053940 267840 Endotoxin ( LPS ) and *increased* the expression of tissue factor , a membrane anchored [glycoprotein] that initiates blood coagulation on the surface of cultured human umbilical vein endothelial cells ( HUVEC ) and human monocyte/macrophages . Positive_regulation GP6 IL1B 8102337 225863 Endotoxin ( LPS ) , and tumor necrosis factor-alpha (TNF) *increased* the expression of tissue factor , a membrane anchored [glycoprotein] that initiates blood coagulation on the surface of cultured bovine aortic endothelial cells ( ABAE ) and human monocytes . Positive_regulation GP6 IL1B 8815590 366046 Endotoxin ( LPS ) and *increased* in a dose dependent manner the expression of tissue factor , an ubiquitous membrane anchored [glycoprotein] that initiates blood coagulation at the surface of human umbilical vein endothelial cells ( HUVEC and human peripheral blood mononuclear cells ( PBMC ) . Positive_regulation GP6 ITGB2 3539226 69227 Polymorphic [glycoprotein-1] on mouse platelets : possible *role* of Pgp-1 and in antibody dependent platelet cytotoxicity involving complement . Positive_regulation GP6 MMP28 15339851 1353721 The metalloproteinase ( ) inhibitors GM6001 and TAPI *prevented* both the clearance of [GP VI] from the platelet surface and the appearance of the soluble cleavage product . Positive_regulation GP6 MMP7 15339851 1353736 The metalloproteinase ( ) inhibitors GM6001 and TAPI *prevented* both the clearance of [GP VI] from the platelet surface and the appearance of the soluble cleavage product . Positive_regulation GP6 SPHK1 24385389 2906774 Sphingosine also reduced [P-glycoprotein] transport activity and those effects were *blocked* by an inhibitor of and by the S1PR1 antagonist . Positive_regulation GP6 TNF 1324245 194989 Macrophage membrane [glycoprotein] binding of Griffonia simplicifolia I-B4 *induces* production and a tumoricidal response . Positive_regulation GP6 TNF 15659313 1364876 *Role* of in down-regulation of hepatic cytochrome P450 and [P-glycoprotein] by endotoxin . Positive_regulation GP6 TNF 15659313 1364888 We investigated the *role* of in the down-regulation of hepatic [P-glycoprotein] and cytochrome P450 ( CYP ) by endotoxin , using TNF-alpha gene-deficient (TNF-alpha-/-) mice . Positive_regulation GP6 TNF 17132686 1693458 signaled through TNF-R1 , which in turn caused ET release and action through ETA and ETB receptors , nitric-oxide synthase , protein kinase C and nuclear factor-kappaB (NF-kappaB) and finally *increased* [P-glycoprotein] expression and transport activity . Positive_regulation GP6 TNF 17982267 1821202 *activates* [P-glycoprotein] in cerebral microvascular endothelial cells . Positive_regulation GP6 TNF 7907642 250428 Furthermore , recombinant *had* no effect on the induction of P [glycoprotein] expression in U1 cells . Positive_regulation GP6 TNF 8102337 225862 Endotoxin ( LPS ) , interleukin-1 beta (IL-1) and *increased* the expression of tissue factor , a membrane anchored [glycoprotein] that initiates blood coagulation on the surface of cultured bovine aortic endothelial cells ( ABAE ) and human monocytes . Positive_regulation GP6 TNF 8968260 402442 To test the hypothesis that after cecal ligation and puncture in the rat , there is increased expression of the *dependent* , acute-phase reactant alpha 1-acid [glycoprotein] in the liver , and that this change correlates temporally with increased abundance of TNF-alpha in the hepatic parenchyma but not with circulating concentrations of TNF-alpha . Positive_regulation GP9 CAPN8 9369069 463979 Investigation of the mechanisms involved in shear dependent microparticle generation showed that binding of von Willebrand factor to platelet [glycoprotein] Ib , influx of extracellular calcium , and *activation* of platelet were required to generate microparticles under high shear stress conditions . Positive_regulation GP9 EDN2 8476633 218520 In mucosal explant cultures , ET-1 and *stimulated* lactoferrin and mucous [glycoprotein] release from serous and mucous cells , but ET-3 was inactive . Positive_regulation GP9 F2R 8608229 352698 The experiments with TRAP showed that activation of the seven-transmembrane domain can *result* in translocation of GPIb , [GPIX] , and GPV to the SCCS independently of the GPIb mediated pathway of thrombin induced platelet activation . Positive_regulation GP9 IL1B 11052809 743456 Fibronectin (FN) , a matrix [glycoprotein] highly expressed in injured tissues , can *induce* expression of in human blood monocytic cells . Positive_regulation GP9 IL1B 8053940 267843 Endotoxin ( LPS ) and *increased* the expression of tissue factor , a membrane anchored [glycoprotein] that initiates blood coagulation on the surface of cultured human umbilical vein endothelial cells ( HUVEC ) and human monocyte/macrophages . Positive_regulation GP9 IL1B 8102337 225869 Endotoxin ( LPS ) , and tumor necrosis factor-alpha (TNF) *increased* the expression of tissue factor , a membrane anchored [glycoprotein] that initiates blood coagulation on the surface of cultured bovine aortic endothelial cells ( ABAE ) and human monocytes . Positive_regulation GP9 IL1B 8815590 366049 Endotoxin ( LPS ) and *increased* in a dose dependent manner the expression of tissue factor , an ubiquitous membrane anchored [glycoprotein] that initiates blood coagulation at the surface of human umbilical vein endothelial cells ( HUVEC and human peripheral blood mononuclear cells ( PBMC ) . Positive_regulation GP9 ITGB2 3539226 69233 Polymorphic [glycoprotein-1] on mouse platelets : possible *role* of Pgp-1 and in antibody dependent platelet cytotoxicity involving complement . Positive_regulation GP9 SPHK1 24385389 2906780 Sphingosine also reduced [P-glycoprotein] transport activity and those effects were *blocked* by an inhibitor of and by the S1PR1 antagonist . Positive_regulation GP9 TNF 1324245 194992 Macrophage membrane [glycoprotein] binding of Griffonia simplicifolia I-B4 *induces* production and a tumoricidal response . Positive_regulation GP9 TNF 15659313 1364879 *Role* of in down-regulation of hepatic cytochrome P450 and [P-glycoprotein] by endotoxin . Positive_regulation GP9 TNF 15659313 1364891 We investigated the *role* of in the down-regulation of hepatic [P-glycoprotein] and cytochrome P450 ( CYP ) by endotoxin , using TNF-alpha gene-deficient (TNF-alpha-/-) mice . Positive_regulation GP9 TNF 17132686 1693461 signaled through TNF-R1 , which in turn caused ET release and action through ETA and ETB receptors , nitric-oxide synthase , protein kinase C and nuclear factor-kappaB (NF-kappaB) and finally *increased* [P-glycoprotein] expression and transport activity . Positive_regulation GP9 TNF 17982267 1821205 *activates* [P-glycoprotein] in cerebral microvascular endothelial cells . Positive_regulation GP9 TNF 7907642 250431 Furthermore , recombinant *had* no effect on the induction of P [glycoprotein] expression in U1 cells . Positive_regulation GP9 TNF 8102337 225868 Endotoxin ( LPS ) , interleukin-1 beta (IL-1) and *increased* the expression of tissue factor , a membrane anchored [glycoprotein] that initiates blood coagulation on the surface of cultured bovine aortic endothelial cells ( ABAE ) and human monocytes . Positive_regulation GP9 TNF 8968260 402526 To test the hypothesis that after cecal ligation and puncture in the rat , there is increased expression of the *dependent* , acute-phase reactant alpha 1-acid [glycoprotein] in the liver , and that this change correlates temporally with increased abundance of TNF-alpha in the hepatic parenchyma but not with circulating concentrations of TNF-alpha . Positive_regulation GPER1 CTGF 19153601 2043246 As the activation of [GPR30] by OHT also *induces* in fibroblasts from breast tumour biopsies , these pathways may be involved in promoting aggressive behaviour of breast tumours in response to endogenous oestrogens or to OHT being used for endocrine therapy . Positive_regulation GPER1 EPHB2 21266576 2409559 Moreover , we show that HIF-1a-responsive elements located within the promoter region of GPER are involved in hypoxia dependent transcription of [GPER] , which *requires* the ROS induced activation of signaling in both SkBr3 and HL-1 and cells . Positive_regulation GPER1 EPHB2 21673097 2455359 GPER is expressed in MIN6 cells , where estradiol and the [GPER-selective] agonist G-1 mediate calcium mobilization and *activation* of and phosphatidylinositol 3-kinase . Positive_regulation GPER1 EPHB2 21673097 2455365 Our results indicate that [GPER] *activation* of the epidermal growth factor receptor and in response to estradiol treatment plays a critical role in the secretion of insulin from ß-cells . Positive_regulation GPER1 ITGAL 8207199 261371 Although CD4 transfection in CD4low HUT78 T cell lines did not significantly modify their maximal binding to B cells and fibroblasts , it made the *dependent* adhesion sensitive to inhibition by anti-CD4 Ab , HIV-1 ( env ) gp 160 , and a [12-mer] peptide encompassing the 35-46 sequence of the beta 1 domain of the MHC class II molecule . Positive_regulation GPHB5 IL1B 19095738 2060624 Because NF-kappaB is known to associate with acute phase inflammatory cytokines , we examined whether TNFalpha or could *regulate* [GPB5] . Positive_regulation GPHB5 TNF 19095738 2060623 Because NF-kappaB is known to associate with acute phase inflammatory cytokines , we examined whether or IL-1beta could *regulate* [GPB5] . Positive_regulation GPI ANGPT1 2485042 83986 The enhancement of [PGI2] generation *induced* by or BK was not affected by the pretreatment with captopril . Positive_regulation GPI ANGPT1 2485042 83990 and ( d ) in EC , the *stimulation* of [PGI2] generation by or BK is probably regulated by an activating effect on ACE as an autoregulatory mechanism . Positive_regulation GPI ANGPT1 8496814 219630 These data show that and Ang II *stimulate* PGE2 and [PGI2] release via activation of both AT1 and AT2 receptors in porcine VSMC . Positive_regulation GPI ARSA 12934393 1132819 combined with PER *led* to a significant increase in [PGI2/TXA2] ( P < 0.01 ) together with a significant decrease in the NE levels ( P < 0.01 ) in the rabbits ' blood , and then improved the cardiac output , i.e. increased LVSP ( P < 0.01 ) , and decreased the heart rate ( P < 0.01 ) and LVEDP ( P < 0.01 ) to a greater extent in the arteriosclerosis rabbit models . Positive_regulation GPI ARSA 1959184 172556 Thus , the ASA induced decrease in [PGI2] may in large part be an unavoidable *consequence* of induced platelet cyclooxygenase inhibition . Positive_regulation GPI ARSA 2663547 114518 *causes* a longlasting inhibition of platelet TxA2 production and a more shortlasting inhibition of [PGI2] production . Positive_regulation GPI CD14 9030980 405918 Both serum dependent and serum independent activation of M [phi] by LPS *require* cellular , as evidence by blocking studies with CD14-specific antibodies . Positive_regulation GPI EDN2 1292682 207796 *induced* biphasic changes in [pHi] : initial decrease followed by a subsequent increase above the basal level due to activation of the Na+/H+ exchange . Positive_regulation GPI EDN2 1811280 177287 We evaluated the effect of aging on spontaneous release of prostaglandin I2 ( PGI2 ; measured as 6-keto-PGF1a ) as well as on *induced* release of [PGI2] from isolated hind legs perfused with Krebs-Ringer solution in 5-week-old , 10-week-old and 40-week-old Wistar-Kyoto rats ( WKY ) and age matched spontaneously hypertensive rats ( SHR ) . Positive_regulation GPI EDN2 1811280 177290 These results not only suggest that there exists a much greater reservoir of vascular PGI2 synthesis in SHR , but also imply that the enhanced release of [PGI2] in *response* to , the most potent vasoconstrictor known , may function as a factor or a modulator to attenuate endothelin induced vasoconstriction in senescent SHR . Positive_regulation GPI EDN2 7778066 309340 In order to determine whether this effect is mediated via protein kinase C and Na ( + ) -H+ linked pathways , the effects of staurosporine and calphostin C ( protein kinase C inhibitors ) and 5- ( N , N-hexamethylene ) amiloride ( Na ( + ) -H+ exchange blocker ) on *induced* [pHi] responses in human platelets were assessed . Positive_regulation GPI F2R 8360259 227770 activating peptides ( TRAPs ) as short as 5 amino acids *induced* significant levels of [PGI2] synthesis and expression of PDGF mRNA in human endothelium and produced dose dependent cellular contraction and permeability of confluent human umbilical vein and bovine pulmonary artery endothelial monolayers . Positive_regulation GPI IL1B 1443100 205109 Following the observation that production in lipopolysaccharide ( LPS ) activated monocytes *increases* in concert with a rise in intracellular pH ( [pHi] ) , the role of ion transport in IL-1 beta production was investigated . Positive_regulation GPI IL1B 14629650 1170409 *increased* [PGI2] production in a dose dependent manner . Positive_regulation GPI IL1B 19135800 2037693 The [PGI] also *induced* a prominent increase in and TNF-alpha levels in the DRG and of cyclooxygenase-2 (COX-2) expression in neurons and satellite cells . Positive_regulation GPI IL1B 9243808 446199 LPS , and TNF alpha effectively *enhanced* BK-stimulated production of [PGI2] by HPASMC , while IFN gamma had only a weak effect on BK-stimulated PGI2 production . Positive_regulation GPI IL1B 9243808 446202 Bradykinin induced *enhancement* of [PGI2] production by LPS , and TNF alpha might be involved in the regulation of pulmonary vascular tension and prevent a paradoxical thrombogenic effect in endotoxin- or cytokine mediated inflammation and acute lung injury . Positive_regulation GPI ITGB2 11818440 908176 Cross linking of [GPI-80] , a possible regulatory molecule of cell adhesion , *induces* up-regulation of expression on neutrophil surfaces and shedding of L-selectin . Positive_regulation GPI LBP 1883513 165622 The complex *stimulates* the M [phi] by binding to its cellular receptor , CD14 ( a monocyte/M phi-specific , phosphatidylinositol anchored surface glycoprotein ) . Positive_regulation GPI MAP2K6 11546664 856593 The mitogen activated protein kinase (MAPK) kinase ( ) inhibitors , PD-98059 and U-0126 , blocked IL-1 alpha induced ERK activation and partially *attenuated* cPLA(2)alpha phosphorylation and [PGI] ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation GPI MAP2K6 21949111 2512425 A inhibitor ( PD98059 ; 25 µM ) also completely *blocked* the rise in [pH(i)] induced by C-PAF , suggesting participation of the MAP kinase signaling cascade downstream of the PAF receptor . Positive_regulation GPI SLC9A2 11447025 835462 We conclude that in rabbit gastric epithelium , NHE1 and NHE4 regulate cell volume and NHE1 and *regulate* [pH(i)] . Positive_regulation GPI SLC9A2 12474076 1023514 The results obtained strongly suggest that NHE-1 and NHE-2 are expressed in the basolateral membrane but that they have different roles : NHE-1 is responsible for pHi recovery after an acid load and is mainly *involved* in steady-state [pHi] and cell volume regulation . Positive_regulation GPI TNF 11360675 765297 The responses of antisense IRAK-2 ODN to IL-1 and *stimulated* [PGI2] release are different . Positive_regulation GPI TNF 12030367 947623 Therefore , we conclude that through activation of endogenous PLC *leads* to cleavage of the [GPI-linkage] of E5'N resulting in loss of E5'N from the extracellular surface . Positive_regulation GPI TNF 12237255 989154 2 *induced* the release of [GPI-80] from human neutrophils in a concentration- and time dependent manner ( in the range of 1-100 u ml(-1) and 30-120 min , respectively ) , but did not affect surface GPI-80 levels . Positive_regulation GPI TNF 12237255 989155 In addition , *induced* [GPI-80] release was inhibited by blocking monoclonal antibodies specific to components of Mac-1 ( CD11b and CD18 ) . Positive_regulation GPI TNF 12588293 1059429 At concentration of 1000 pg mL-1 , *increases* the secretion of [PGI2] and TXA2 , but it decreases the ET-1 concentration . Positive_regulation GPI TNF 14629650 1170410 and MIF also *increased* [PGI2] production , but to a far lesser degree at high concentrations . Positive_regulation GPI TNF 19135800 2037692 The [PGI] also *induced* a prominent increase in IL-1beta and levels in the DRG and of cyclooxygenase-2 (COX-2) expression in neurons and satellite cells . Positive_regulation GPI TNF 1915557 168203 M [phi] NO2- production in *response* to rIFN-gamma and either exogenous or Leishmania was strongly enhanced by prostaglandin E2 , consistent with such a mechanism . Positive_regulation GPI TNF 2113475 135579 In the present study we investigated whether *activates* M [phi] for killing of L. major parasites . Positive_regulation GPI TNF 22964479 2716015 Overall , our results indicate that anti-ß ( 2 ) GPI/ß ( 2 ) [GPI] complex *induced* TF and expression involving both TLR4/MyD88 and TLR4/TRIF signaling pathways and TLR4 and its adaptors might be molecular targets for therapy of antiphospholipid syndrome (APS) . Positive_regulation GPI TNF 24157085 2868195 Overall , our results indicate that [anti-ß2GPI/ß2GPI] complex *induced* IL-6 , IL-8 and expression involving TLR4/MD-2/MyD88 and NF-?B signaling pathways and this might be associated with pathological mechanisms of antiphospholipid syndrome (APS) . Positive_regulation GPI TNF 3056398 100791 Both IL-1 and *increased* [PGI2] production by EC in both a time- and dose dependent manner , and a combination of the two cytokines additively enhanced PGI2 production . Positive_regulation GPI TNF 3541932 67401 The *stimulation* of [PGI2] by is comparable to that observed with interleukin-1 , the monokine previously suggested to be the principal mediator of this effect . Positive_regulation GPI TNF 3541932 67402 The ability of to *stimulate* [PGI2] production suggests that it may play a role in producing depressed blood pressure or shock . Positive_regulation GPI TNF 7487461 326909 If so , down-regulation might *contribute* to functional PM [phi] suppression after systemic injury . Positive_regulation GPI TNF 7815559 292857 This suggests that IFN gamma- and *mediated* M [phi] activation is an important aspect of innate immunity to viral infection . Positive_regulation GPI TNF 7815559 292858 As the M phi may be involved in MCMV latency , IFN gamma- and *dependent* M [phi] activation during primary infection may be relevant to establishment of viral latency . Positive_regulation GPI TNF 8244447 236705 A PGE2-specific enzyme linked immunosorbent assay showed that TBH M phi T cell cultures contained significantly more PGE2 than those containing NH M [phi] , and that exogenous *increased* PGE2 production in TBH M phi cultures more than in NH M phi cultures . Positive_regulation GPI TNF 8257696 238580 Indeed , cholesterol enrichment attenuated IL-1 beta- , PDGF- , and *induced* [PGI2] synthesis relative to controls and was consistent with the results of in vitro labeling experiments demonstrating that cholesterol enrichment reduced the incorporation of [ 35S ] methionine into immunoprecipitable COX-1 and COX-2 following induction by PDGF . Positive_regulation GPI TNF 8442433 213511 also *enhanced* the biosynthesis of [PGI2] , as assessed by analysis of the stable breakdown product 6-keto-PGF1 alpha . Positive_regulation GPI TNF 8596041 351175 The direct activation of endothelial cells by [GPI] does not *require* the participation of or IL-1 . Positive_regulation GPI TNF 8683148 370282 We hypothesized that *enhanced* the M [phi] response to CSF-1 in MRL-lpr mice . Positive_regulation GPI TNF 9242534 446071 Phorbol 12-myristate 13-acetate ( PMA ) , interleukin-1 (IL-1) , IL-3 , IL-6 , granulocyte-macrophage colony stimulating factor ( GM-CSF ) , thrombopoietin (TPO) , and *enhanced* [PGI2-R] mRNA expression . Positive_regulation GPI TNF 9243808 446197 LPS , IL-1 beta and effectively *enhanced* BK-stimulated production of [PGI2] by HPASMC , while IFN gamma had only a weak effect on BK-stimulated PGI2 production . Positive_regulation GPI TNF 9243808 446201 Bradykinin induced *enhancement* of [PGI2] production by LPS , IL-1 beta and might be involved in the regulation of pulmonary vascular tension and prevent a paradoxical thrombogenic effect in endotoxin- or cytokine mediated inflammation and acute lung injury . Positive_regulation GPI TNF 9575350 408254 and LPS each *induce* [PGI2] production in a concentration and time dependent manner . Positive_regulation GPI TNF 9575350 408255 The capacity of SAA to markedly moderate [PGI2] *induction* by and LPS suggest that it may play a role in defending against vessel damage , in cases of atherosclerosis , bacterial infection or septic shock . Positive_regulation GPNMB IFNG 17475886 1738532 [Gpnmb] is *induced* in macrophages by and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses . Positive_regulation GPNMB MITF 24789918 2956128 Lysosomal stress in obese adipose tissue macrophages contributes to *dependent* [Gpnmb] induction . Positive_regulation GPNMB MYCN 22290289 2636608 [GPNMB] overexpression *induced* the gene expressions of downstream regulated gene 1 ( Ndrg1 ) and maspin in PC-3 cells . Positive_regulation GPNMB NDRG1 22290289 2636609 [GPNMB] overexpression *induced* the gene expressions of N-myc downstream regulated gene 1 ( ) and maspin in PC-3 cells . Positive_regulation GPNMB SERPINB5 22290289 2636610 [GPNMB] overexpression *induced* the gene expressions of N-myc downstream regulated gene 1 ( Ndrg1 ) and in PC-3 cells . Positive_regulation GPNMB TCF12 18313864 1891797 Microphthalmia *regulates* the expression of the novel osteoclast factor [GPNMB] . Positive_regulation GPNMB TCF15 18313864 1891798 Microphthalmia *regulates* the expression of the novel osteoclast factor [GPNMB] . Positive_regulation GPNMB TCF19 18313864 1891799 Microphthalmia *regulates* the expression of the novel osteoclast factor [GPNMB] . Positive_regulation GPNMB TCF20 18313864 1891800 Microphthalmia *regulates* the expression of the novel osteoclast factor [GPNMB] . Positive_regulation GPNMB TCF21 18313864 1891801 Microphthalmia *regulates* the expression of the novel osteoclast factor [GPNMB] . Positive_regulation GPNMB TCF23 18313864 1891805 Microphthalmia *regulates* the expression of the novel osteoclast factor [GPNMB] . Positive_regulation GPNMB TCF24 18313864 1891807 Microphthalmia *regulates* the expression of the novel osteoclast factor [GPNMB] . Positive_regulation GPNMB TCF25 18313864 1891806 Microphthalmia *regulates* the expression of the novel osteoclast factor [GPNMB] . Positive_regulation GPNMB TCF3 18313864 1891802 Microphthalmia *regulates* the expression of the novel osteoclast factor [GPNMB] . Positive_regulation GPNMB TCF4 18313864 1891803 Microphthalmia *regulates* the expression of the novel osteoclast factor [GPNMB] . Positive_regulation GPNMB TCF7 18313864 1891804 Microphthalmia *regulates* the expression of the novel osteoclast factor [GPNMB] . Positive_regulation GPNMB TFE3 21209915 2359461 Since TFE3 is implicated in RCC , we hypothesized that elevated [GPNMB] expression was *due* to increased activity resulting from the inactivation of FLCN . Positive_regulation GPNMB TYR 16827931 1600153 As demonstrated here , the [Gpnmb] and Tyrp1 iris phenotypes are both individually *dependent* on function . Positive_regulation GPR1 RGS2 19427970 2076860 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR101 RGS2 19427970 2076816 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR107 RGS2 19427970 2076821 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR108 RGS2 19427970 2076820 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR110 RGS2 19427970 2076826 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR111 RGS2 19427970 2076827 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR112 RGS2 19427970 2076828 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR113 RGS2 19427970 2076825 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR114 RGS2 19427970 2076829 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR115 ABL1 16291747 1510180 We performed in vitro kinase activity assays and show that also leads to increased p110gamma activity and that this activation *requires* both [G protein coupled receptor] and Ras signaling . Positive_regulation GPR115 ADCYAP1 17680996 1805439 These results therefore identify the *induced* translocation of its [G-protein coupled receptor] into caveolae , where both AC and the regulating G-proteins reside , as the key molecular event in activating AC and inducing cAMP mediated differentiation of PC12 cells . Positive_regulation GPR115 ADCYAP1 23284775 2711549 PAC1 is PACAP ( pituitary adenylate cyclase activating polypeptide ) preferring receptor belonging to class B [G protein coupled receptor (GPCR)] *mediating* the most effects of . Positive_regulation GPR115 ADRBK1 19815545 2164288 Our results suggest a novel mechanism by which negatively *regulates* [G protein coupled receptor] signaling in a manner that is independent of receptor phosphorylation . Positive_regulation GPR115 ANGPT2 18515110 1928492 Cyclooxygenase-2 (COX-2) is rapidly *induced* by in the non-tumorigenic , rat intestinal epithelial cell line , IEC-18 , through its [G-protein coupled receptor] , AT1R . Positive_regulation GPR115 ANGPT2 7699989 288230 The physiologic effects of are *mediated* by a [G-protein coupled receptor] , termed AT1 , which activates phospholipase C . Positive_regulation GPR115 ANGPT2 8088922 271509 These findings suggest that *induces* the phosphorylation of its own [G protein coupled receptor] through both serine and tyrosine kinases and raise the possibility that phosphorylation of the AT1AR is an important regulator of receptor function . Positive_regulation GPR115 ANGPT2 9421435 481014 In view of this unique property and the presence of putative nuclear localization signal ( NLS ) consensus sequence in the AT1 receptor , this study was conducted to investigate the hypothesis that would *induce* nuclear sequestration of this [G protein coupled receptor] and that the sequestration may have implications on Ang II-induced expression of NET and TH genes . Positive_regulation GPR115 ANXA6 9299479 453505 Wortmannin-sensitive *activation* of and MAP-kinase by the [G protein coupled receptor] , G/CCKB . Positive_regulation GPR115 BCR 16291747 1510177 We performed in vitro kinase activity assays and show that also leads to increased p110gamma activity and that this activation *requires* both [G protein coupled receptor] and Ras signaling . Positive_regulation GPR115 CALM3 10496966 647265 The first mechanism is based on recent in vitro studies demonstrating that [G protein coupled receptor kinase (GRK)] activity , the protein kinase responsible for beta(2)-adrenergic receptor homologous phosphorylation and desensitization , may be *regulated* by and membrane phosphatidylinositol 4 , 5-bisphosphate . Positive_regulation GPR115 CAT 11751593 898502 [GAL4/PR-B] and VP16/PR-B *induced* ( approximately 3- to 4-fold ) activity in a progesterone dependent manner , suggesting PR-dimer formation . Positive_regulation GPR115 CCL2 23877010 2839332 The chemokine receptor CCR2 is a [G protein coupled receptor] that is *activated* primarily by the endogenous . Positive_regulation GPR115 CD79A 16291747 1510178 We performed in vitro kinase activity assays and show that also leads to increased p110gamma activity and that this activation *requires* both [G protein coupled receptor] and Ras signaling . Positive_regulation GPR115 CD79B 16291747 1510179 We performed in vitro kinase activity assays and show that also leads to increased p110gamma activity and that this activation *requires* both [G protein coupled receptor] and Ras signaling . Positive_regulation GPR115 CSK 16501257 1541469 *Role* of tyrosine kinase in [G protein coupled receptor-] and receptor tyrosine kinase induced fibroblast cell migration . Positive_regulation GPR115 CSK 8702633 375648 *Role* of in [G protein coupled receptor-] and Gbetagamma subunit mediated activation of mitogen activated protein kinases . Positive_regulation GPR115 CXCR4 15292258 1303038 Its numerous biological effects are *mediated* by a specific [G protein coupled receptor] , . Positive_regulation GPR115 EGF 12880866 1115887 This is the first demonstration of a *role* of receptor transactivation in the phosphorylation of a [G protein coupled receptor] . Positive_regulation GPR115 EGFR 11502566 847513 We examined the *role* of ( EGFR ) tyrosine kinase activation in [G protein coupled receptor (GPCR)] agonist induced mitogenesis in Swiss 3T3 and Rat-1 cells . Positive_regulation GPR115 EGFR 18658095 2010739 ERK1/2 mediate wounding- and [G-protein coupled receptor] ligands *induced* activation via regulating ADAM17 and HB-EGF shedding . Positive_regulation GPR115 EGFR 19587094 2129456 [G protein coupled receptor (GPCR)] *activation* of has been reported to involve Src 's activation via a GPCR-beta-arrestin-Src complex . Positive_regulation GPR115 ETS1 18094067 1874956 Conversely , in the PHR , *increased* TH activity through a [G protein coupled receptor] , likely an atypical ET receptor or the ET ( C ) receptor , which stimulated the phosphoinositide and adenylyl cyclase pathways , as well as CaMK-II . Positive_regulation GPR115 ETS2 18094067 1874957 Conversely , in the PHR , *increased* TH activity through a [G protein coupled receptor] , likely an atypical ET receptor or the ET ( C ) receptor , which stimulated the phosphoinositide and adenylyl cyclase pathways , as well as CaMK-II . Positive_regulation GPR115 FLNA 16513120 1535788 Using short interfering RNA ( siRNA ) to selectively target the filamin A gene and silence its expression , we studied the *role* of in [G protein coupled receptor (GPCR)] signaling . Positive_regulation GPR115 GH1 15361691 1303853 Ghrelin and the synthetic *activate* a [G-protein coupled receptor] ( GHS-R ) originally cloned from the pituitary , but which is also expressed in the hypothalamus , in other areas of the brain and in numerous peripheral tissues . Positive_regulation GPR115 GNB1 16129667 1474383 *Activation* of a by an agonist stimulated [G-protein coupled receptor] requires the propagation of structural signals from the receptor binding interface to the guanine nucleotide binding pocket of the G-protein . Positive_regulation GPR115 GNB2L1 18088317 1862426 *regulates* the cell surface expression of the [G protein coupled receptor] for thromboxane A ( 2 ) . Positive_regulation GPR115 GNG2 16129667 1474384 *Activation* of a by an agonist stimulated [G-protein coupled receptor] requires the propagation of structural signals from the receptor binding interface to the guanine nucleotide binding pocket of the G-protein . Positive_regulation GPR115 GNRH1 23321696 2733390 Using a high-throughput ß-arrestin recruitment assay , we identified an orphan [G protein coupled receptor] ( GPR173 ) that was specifically *activated* by ( 1-5 ) . Positive_regulation GPR115 GRAP2 9915820 587230 These results demonstrate for the first time that apart from ERK , *activation* by a [G protein coupled receptor] can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation GPR115 GRK1 17971124 1858928 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Positive_regulation GPR115 GRK1 18056263 1852755 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Positive_regulation GPR115 GRK4 17971124 1858930 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Positive_regulation GPR115 GRK4 18056263 1852757 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Positive_regulation GPR115 GRK5 17971124 1858931 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Positive_regulation GPR115 GRK5 18056263 1852758 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Positive_regulation GPR115 GRK6 17971124 1858932 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Positive_regulation GPR115 GRK6 18056263 1852759 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Positive_regulation GPR115 GRK7 17971124 1858929 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Positive_regulation GPR115 GRK7 18056263 1852756 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Positive_regulation GPR115 HSPG2 17077647 1650019 The inhibitor effect of dipyrone on IP accumulation may be due to direct inhibition of phospholipase C (PLC) or impairment of the *activation* of by [G protein coupled receptor (GPCR)] . Positive_regulation GPR115 HTN1 19652025 2150102 Activation of cells by *requires* a [G-protein coupled receptor] that activates the ERK1/2 pathway . Positive_regulation GPR115 HTN3 19652025 2150103 Activation of cells by *requires* a [G-protein coupled receptor] that activates the ERK1/2 pathway . Positive_regulation GPR115 IAPP 23966942 2832553 Both and Aß directly *activate* this [G protein coupled receptor] and trigger multiple common intracellular signal transduction pathways that can culminate in apoptotic cell death . Positive_regulation GPR115 IL8 12393391 1035219 Serum amyloid A *induces* secretion through a [G protein coupled receptor] , FPRL1/LXA4R . Positive_regulation GPR115 IL8 24164922 2882774 Transcriptome analyses revealed that Caco-2 BBE cells respond to stimulation with IL-8 supporting the hypothesis that *induces* [G protein coupled receptor] signalling . Positive_regulation GPR115 INS 15388645 1354047 Substitution of the C-terminal cytoplasmic tail of the beta2-adrenergic receptor on the beta1-adrenergic receptor enabled the chimeric [G protein coupled receptor] to be functionally and spatially *regulated* by . Positive_regulation GPR115 KRT13 16936773 1700088 *induces* the expression of several genes known to be upregulated in HHV8 transformed vascular endothelial cells , such as interleukin (IL)-6 , IL-8 , CXC ligand 3 (CXCL3) , orphan [G protein coupled receptor] ( RDC1 ) , cyclooxygenase-2 (COX-2) and dual-specificity phosphatase 5 (DUSP5) . Positive_regulation GPR115 LPA 19679818 2180417 P2Y5 is a [G protein coupled receptor] that binds and is *activated* by . Positive_regulation GPR115 LPA 21454702 2427815 Cleavage was stimulated by phorbol ester ( 12-O-tetradecanoylphorbol-13-acetate ( TPA ) , a mimic of diacylglycerol and PKC activator ) , hypertonic stress , induced [G protein coupled receptor] *activation* , or by ionomycin induced intracellular calcium release . Positive_regulation GPR115 LPA 8489494 219248 *activates* a putative [G-protein coupled receptor] in responsive cells , but the natural source of exogenous LPA is unknown . Positive_regulation GPR115 MAPK1 16611986 1545639 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR115 MAPK10 16611986 1545640 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR115 MAPK11 16611986 1545641 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR115 MAPK12 16611986 1545642 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR115 MAPK13 16611986 1545643 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR115 MAPK14 16611986 1545644 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR115 MAPK15 16611986 1545638 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR115 MAPK3 16611986 1545645 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR115 MAPK4 16611986 1545646 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR115 MAPK6 16611986 1545647 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR115 MAPK7 16611986 1545648 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR115 MAPK8 16611986 1545649 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR115 MAPK9 16611986 1545650 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR115 MED1 18992245 1996267 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory *induced* [G-protein coupled receptor] activation . Positive_regulation GPR115 MED1 7733903 303150 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED10 18992245 1996262 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR115 MED10 7733903 303145 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED11 18992245 1996265 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory *induced* [G-protein coupled receptor] activation . Positive_regulation GPR115 MED11 7733903 303148 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED13 18992245 1996249 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR115 MED13 7733903 303132 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED13L 18992245 1996250 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory *induced* [G-protein coupled receptor] activation . Positive_regulation GPR115 MED13L 7733903 303133 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED14 18992245 1996254 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory *induced* [G-protein coupled receptor] activation . Positive_regulation GPR115 MED14 7733903 303137 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED15 18992245 1996243 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR115 MED15 7733903 303126 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED16 18992245 1996245 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR115 MED16 7733903 303128 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED17 18992245 1996256 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory *induced* [G-protein coupled receptor] activation . Positive_regulation GPR115 MED17 7733903 303139 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED18 18992245 1996261 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory *induced* [G-protein coupled receptor] activation . Positive_regulation GPR115 MED18 7733903 303144 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED19 18992245 1996264 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR115 MED19 7733903 303147 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED20 18992245 1996244 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory *induced* [G-protein coupled receptor] activation . Positive_regulation GPR115 MED20 7733903 303127 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED21 18992245 1996241 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR115 MED21 7733903 303124 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED22 18992245 1996242 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory *induced* [G-protein coupled receptor] activation . Positive_regulation GPR115 MED22 7733903 303125 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED23 18992245 1996255 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR115 MED23 7733903 303138 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED24 18992245 1996251 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR115 MED24 7733903 303134 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED25 18992245 1996263 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory *induced* [G-protein coupled receptor] activation . Positive_regulation GPR115 MED25 7733903 303146 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED26 18992245 1996257 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR115 MED26 7733903 303140 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED27 18992245 1996258 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory *induced* [G-protein coupled receptor] activation . Positive_regulation GPR115 MED27 7733903 303141 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED29 18992245 1996253 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR115 MED29 7733903 303136 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED30 18992245 1996252 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory *induced* [G-protein coupled receptor] activation . Positive_regulation GPR115 MED30 7733903 303135 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED31 18992245 1996260 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR115 MED31 7733903 303143 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED4 18992245 1996246 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory *induced* [G-protein coupled receptor] activation . Positive_regulation GPR115 MED4 7733903 303129 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED6 18992245 1996247 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR115 MED6 7733903 303130 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED7 18992245 1996259 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory *induced* [G-protein coupled receptor] activation . Positive_regulation GPR115 MED7 7733903 303142 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 MED8 18992245 1996248 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory *induced* [G-protein coupled receptor] activation . Positive_regulation GPR115 MED8 7733903 303131 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 NFKB1 11815436 907787 In this study , we examined the *role* of an ROS-sensitive transcriptional factor , , and a mitogen activated protein kinase kinase kinase , apoptosis signal regulating kinase 1 ( ASK1 ) , in [G-protein coupled receptor (GPCR)] agonist ( angiotensin II , endothelin-1 , phenylephrine ) -induced cardiac hypertrophy in isolated rat neonatal cardiomyocytes . Positive_regulation GPR115 NFKB1 21159881 2384866 Phosphorylation and polyubiquitination of transforming growth factor beta activated kinase 1 are necessary for *activation* of by the Kaposi 's sarcoma associated herpesvirus [G protein coupled receptor] . Positive_regulation GPR115 NPS 15731503 1377615 *activates* an orphan [G protein coupled receptor] that is expressed throughout the central nervous system , including brain centers that regulate sleep/wakefulness and anxiety . Positive_regulation GPR115 NPS 17613937 1768813 *activates* its cognate [G protein coupled receptor] at low nanomolar agonist concentrations and induces elevation of intracellular Ca2+ and cAMP , therefore acting as an excitatory transmitter . Positive_regulation GPR115 OPA1 18992245 1996266 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory *induced* [G-protein coupled receptor] activation . Positive_regulation GPR115 OPA1 7733903 303149 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR115 PAK1 14695200 1180073 *Activation* of factor kappaB signaling by Kaposi 's sarcoma associated herpes virus [G protein coupled receptor] during cellular transformation . Positive_regulation GPR115 PHKA2 14963038 1235398 is a member of the focal adhesion kinase family and can be *activated* by c-Src , epidermal growth factor receptor (EGFR) , Janus kinase 1 , tyrosine kinases , and [G-protein coupled receptor] signaling . Positive_regulation GPR115 PHKA2 15911746 1420158 Role of the actin cytoskeleton in [G-protein coupled receptor] *activation* of and paxillin in vascular smooth muscle . Positive_regulation GPR115 PI3 10187765 602541 Furthermore , we show that the p85 regulatory subunit is required for *activation* of activity by this [G protein coupled receptor] . Positive_regulation GPR115 PIK3CB 18594509 1947010 However , the kinase activity of was *required* for [G-protein coupled receptor] signalling triggered by lysophosphatidic acid and had a function in oncogenic transformation . Positive_regulation GPR115 PITRM1 24732013 2936110 The protease activated receptor 1 (PAR1) is a [G-protein coupled receptor] that is irreversibly *activated* by either thrombin or . Positive_regulation GPR115 PRKACB 20826718 2352415 We show here that Gs-linked [G protein coupled receptor] *activation* of cAMP dependent plays an important role in regulating the switch between endothelial cell adhesion and migration by activating C-terminal Src kinase , leading to inhibition of pp60Src . Positive_regulation GPR115 PRKACG 20826718 2352416 We show here that Gs-linked [G protein coupled receptor] *activation* of cAMP dependent plays an important role in regulating the switch between endothelial cell adhesion and migration by activating C-terminal Src kinase , leading to inhibition of pp60Src . Positive_regulation GPR115 PRKAR1A 20826718 2352417 We show here that Gs-linked [G protein coupled receptor] *activation* of cAMP dependent plays an important role in regulating the switch between endothelial cell adhesion and migration by activating C-terminal Src kinase , leading to inhibition of pp60Src . Positive_regulation GPR115 PRKAR1B 20826718 2352418 We show here that Gs-linked [G protein coupled receptor] *activation* of cAMP dependent plays an important role in regulating the switch between endothelial cell adhesion and migration by activating C-terminal Src kinase , leading to inhibition of pp60Src . Positive_regulation GPR115 PRKAR2A 20826718 2352419 We show here that Gs-linked [G protein coupled receptor] *activation* of cAMP dependent plays an important role in regulating the switch between endothelial cell adhesion and migration by activating C-terminal Src kinase , leading to inhibition of pp60Src . Positive_regulation GPR115 PRKAR2B 20826718 2352420 We show here that Gs-linked [G protein coupled receptor] *activation* of cAMP dependent plays an important role in regulating the switch between endothelial cell adhesion and migration by activating C-terminal Src kinase , leading to inhibition of pp60Src . Positive_regulation GPR115 PTGS2 17868457 1810550 Kaposi 's sarcoma associated herpesvirus [G-protein coupled receptor] *activation* of in vascular endothelial cells . Positive_regulation GPR115 PTGS2 18515110 1928493 is rapidly *induced* by angiotensin (Ang)-II in the non-tumorigenic , rat intestinal epithelial cell line , IEC-18 , through its [G-protein coupled receptor] , AT1R . Positive_regulation GPR115 PTH 10438471 634749 A [G protein coupled receptor] from zebrafish is *activated* by human and not by human or teleost parathyroid hormone related peptide . Positive_regulation GPR115 PTH 20172855 2236520 The parathyroid hormone receptor ( PTH1R ) is a class B [G protein coupled receptor] that is *activated* by parathyroid hormone (PTH) and . Positive_regulation GPR115 PTHLH 15515174 1342938 *Activation* of this [G-protein coupled receptor] by has been shown to regulate chondrogenesis in a manner that attenuates chondrocyte hypertrophy . Positive_regulation GPR115 PTK2B 10542211 563597 Kaposi 's sarcoma associated herpesvirus encoded [G protein coupled receptor] activation of c-jun amino-terminal kinase/stress activated protein kinase and lyn kinase is *mediated* by related adhesion focal tyrosine . Positive_regulation GPR115 PXN 15911746 1420159 Role of the actin cytoskeleton in [G-protein coupled receptor] *activation* of PYK2 and in vascular smooth muscle . Positive_regulation GPR115 RELA 11815436 907788 In this study , we examined the *role* of an ROS-sensitive transcriptional factor , , and a mitogen activated protein kinase kinase kinase , apoptosis signal regulating kinase 1 ( ASK1 ) , in [G-protein coupled receptor (GPCR)] agonist ( angiotensin II , endothelin-1 , phenylephrine ) -induced cardiac hypertrophy in isolated rat neonatal cardiomyocytes . Positive_regulation GPR115 RELA 21159881 2384867 Phosphorylation and polyubiquitination of transforming growth factor beta activated kinase 1 are necessary for *activation* of by the Kaposi 's sarcoma associated herpesvirus [G protein coupled receptor] . Positive_regulation GPR115 RGS18 17074726 1638057 Our results suggest that [G-protein coupled receptor] mediated signalling in platelet may be *regulated* mainly by , 16 , 10 , 6 , and LARG . Positive_regulation GPR115 RGS2 19427970 2076830 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR115 RGS3 9182581 434718 A truncated form of negatively *regulates* [G protein coupled receptor] stimulation of adenylyl cyclase and phosphoinositide phospholipase C . Positive_regulation GPR115 RHO 10891074 710708 [G protein coupled receptor] *activation* : analysis of a highly constrained , `` straitjacketed '' . Positive_regulation GPR115 RHOA 21167820 2385317 This suggests the involvement of a [G-protein coupled receptor] and *activation* of . Positive_regulation GPR115 RLN3 17132825 1700909 In the rat , binds and *activates* both relaxin family peptide receptor 1 , which also binds relaxin-1 , and a previously orphaned [G protein coupled receptor] , RXFP3 . Positive_regulation GPR115 RLN3 24711793 2931842 is a newly discovered neuropeptide that binds , and *activates* the [G-protein coupled receptor] , RXFP3 . Positive_regulation GPR115 SAA1 12393391 1035216 *induces* IL-8 secretion through a [G protein coupled receptor] , FPRL1/LXA4R . Positive_regulation GPR115 SAA2 12393391 1035217 *induces* IL-8 secretion through a [G protein coupled receptor] , FPRL1/LXA4R . Positive_regulation GPR115 SAA4 12393391 1035218 *induces* IL-8 secretion through a [G protein coupled receptor] , FPRL1/LXA4R . Positive_regulation GPR115 SERPINE1 15808835 1391448 Role of c-Jun NH2-terminal kinase in [G-protein coupled receptor] agonist *induced* cardiac expression . Positive_regulation GPR115 SFTPC 10571530 568567 The effects of could be *mediated* , in part , by activation of a [G protein coupled receptor] and a MAPK signaling cascade . Positive_regulation GPR115 SFTPC 16490345 1597767 The phospholipase C (PLC) inhibitor U 73122 potently attenuated the effect of SPC , suggesting that effects of were *mediated* by a [G protein coupled receptor] . Positive_regulation GPR115 SLC9A1 15494214 1354776 The regulation of NHE1 by growth factors involves the Ras-extracellular signal regulated kinase ( ERK ) pathway , however , the mechanism for [G protein coupled receptor (GPCR)] *activation* of is not well established . Positive_regulation GPR115 SPP1 8567663 349654 Here , we present evidence that *activates* a [G protein coupled receptor] in the plasma membrane of various cells , leading to increase in cytoplasmic Ca2+ concentration ([Ca2+]i) , inhibition of adenylyl cyclase , and opening of G protein regulated potassium channels . Positive_regulation GPR115 SPP2 8567663 349655 Here , we present evidence that *activates* a [G protein coupled receptor] in the plasma membrane of various cells , leading to increase in cytoplasmic Ca2+ concentration ([Ca2+]i) , inhibition of adenylyl cyclase , and opening of G protein regulated potassium channels . Positive_regulation GPR115 SST 8806621 382340 *Role* of in modulating [G protein coupled receptor] signaling . Positive_regulation GPR115 TAS1R2 20493823 2283565 In mammals , sweet taste perception is *mediated* by the heterodimeric [G-protein coupled receptor] , . Positive_regulation GPR115 TAS1R3 20493823 2283566 In mammals , sweet taste perception is *mediated* by the heterodimeric [G-protein coupled receptor] , . Positive_regulation GPR115 TRH 20352046 2231271 T ( 3 ) negatively regulates TSHalpha gene expression via thyroid hormone receptors ( TRs ) which belong to the nuclear hormone receptor superfamily , whereas positively *regulates* via the TRH receptor , a [G protein coupled receptor] . Positive_regulation GPR115 UTS2 22563490 2596239 The peptide *activates* a [G protein coupled receptor] named UT , and mediates potent vasoconstriction or vasodilation in mammalian vasculature . Positive_regulation GPR115 WAS 10787386 688461 The recent identification of a [G-protein coupled receptor] that was *activated* by , the major psychoactive component of marijuana , led to the discovery of endogenous agonists . Positive_regulation GPR115 YME1L1 15823563 1393943 In an effort to identify potential PAMP receptor ( s ) , we found that a human [G-protein coupled receptor] , MrgX2 , was specifically *activated* by . Positive_regulation GPR116 RGS2 19427970 2076831 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR119 RGS2 19427970 2076832 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR12 RGS2 19427970 2076861 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR123 RGS2 19427970 2076813 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR124 RGS2 19427970 2076822 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR125 RGS2 19427970 2076814 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR126 RGS2 19427970 2076815 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR128 RGS2 19427970 2076833 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR132 ABL1 16291747 1510136 We performed in vitro kinase activity assays and show that also leads to increased p110gamma activity and that this activation *requires* both [G protein coupled receptor] and Ras signaling . Positive_regulation GPR132 ADCYAP1 17680996 1805428 These results therefore identify the *induced* translocation of its [G-protein coupled receptor] into caveolae , where both AC and the regulating G-proteins reside , as the key molecular event in activating AC and inducing cAMP mediated differentiation of PC12 cells . Positive_regulation GPR132 ADCYAP1 23284775 2711538 PAC1 is PACAP ( pituitary adenylate cyclase activating polypeptide ) preferring receptor belonging to class B [G protein coupled receptor (GPCR)] *mediating* the most effects of . Positive_regulation GPR132 ADRBK1 19815545 2164277 Our results suggest a novel mechanism by which negatively *regulates* [G protein coupled receptor] signaling in a manner that is independent of receptor phosphorylation . Positive_regulation GPR132 ANGPT2 18515110 1928470 Cyclooxygenase-2 (COX-2) is rapidly *induced* by in the non-tumorigenic , rat intestinal epithelial cell line , IEC-18 , through its [G-protein coupled receptor] , AT1R . Positive_regulation GPR132 ANGPT2 7699989 288219 The physiologic effects of are *mediated* by a [G-protein coupled receptor] , termed AT1 , which activates phospholipase C . Positive_regulation GPR132 ANGPT2 8088922 271498 These findings suggest that *induces* the phosphorylation of its own [G protein coupled receptor] through both serine and tyrosine kinases and raise the possibility that phosphorylation of the AT1AR is an important regulator of receptor function . Positive_regulation GPR132 ANGPT2 9421435 481003 In view of this unique property and the presence of putative nuclear localization signal ( NLS ) consensus sequence in the AT1 receptor , this study was conducted to investigate the hypothesis that would *induce* nuclear sequestration of this [G protein coupled receptor] and that the sequestration may have implications on Ang II-induced expression of NET and TH genes . Positive_regulation GPR132 ANXA6 9299479 453494 Wortmannin-sensitive *activation* of and MAP-kinase by the [G protein coupled receptor] , G/CCKB . Positive_regulation GPR132 APOB 11748189 898091 In this study we demonstrate that the OprI from Pseudomonas aeruginosa *induces* a long-term cellular ( gamma interferon [ IFN-gamma ] ) and humoral ( immunoglobulin [G2a] ) type 1 immune response against a truncated 32-kDa version ( COOHgp63 ) of the 63-kDa major cell surface glycoprotein gp63 . Positive_regulation GPR132 BCR 16291747 1510133 We performed in vitro kinase activity assays and show that also leads to increased p110gamma activity and that this activation *requires* both [G protein coupled receptor] and Ras signaling . Positive_regulation GPR132 CALM3 10496966 647254 The first mechanism is based on recent in vitro studies demonstrating that [G protein coupled receptor kinase (GRK)] activity , the protein kinase responsible for beta(2)-adrenergic receptor homologous phosphorylation and desensitization , may be *regulated* by and membrane phosphatidylinositol 4 , 5-bisphosphate . Positive_regulation GPR132 CAT 11751593 898491 [GAL4/PR-B] and VP16/PR-B *induced* ( approximately 3- to 4-fold ) activity in a progesterone dependent manner , suggesting PR-dimer formation . Positive_regulation GPR132 CCL2 23877010 2839321 The chemokine receptor CCR2 is a [G protein coupled receptor] that is *activated* primarily by the endogenous . Positive_regulation GPR132 CD79A 16291747 1510134 We performed in vitro kinase activity assays and show that also leads to increased p110gamma activity and that this activation *requires* both [G protein coupled receptor] and Ras signaling . Positive_regulation GPR132 CD79B 16291747 1510135 We performed in vitro kinase activity assays and show that also leads to increased p110gamma activity and that this activation *requires* both [G protein coupled receptor] and Ras signaling . Positive_regulation GPR132 CLTA 20799926 2336095 Lysophosphatidylcholines activate [G2A] *inducing* G ( ai ) ?1-/G ( aq/ ) 11- Ca² ( + ) flux , G ( ß? ) -Hck activation and recruitment in PMNs . Positive_regulation GPR132 CLTC 20799926 2336096 Lysophosphatidylcholines activate [G2A] *inducing* G ( ai ) ?1-/G ( aq/ ) 11- Ca² ( + ) flux , G ( ß? ) -Hck activation and recruitment in PMNs . Positive_regulation GPR132 CSK 16501257 1541458 *Role* of tyrosine kinase in [G protein coupled receptor-] and receptor tyrosine kinase induced fibroblast cell migration . Positive_regulation GPR132 CSK 8702633 375637 *Role* of in [G protein coupled receptor-] and Gbetagamma subunit mediated activation of mitogen activated protein kinases . Positive_regulation GPR132 CTSC 17475884 1738531 Enhanced detection of [G2A] *induced* by was paralleled by enhanced detection of CD45 , confirming mobilization of the labile secretory vesicle pool . Positive_regulation GPR132 CXCR4 15292258 1303027 Its numerous biological effects are *mediated* by a specific [G protein coupled receptor] , . Positive_regulation GPR132 EGF 12880866 1115876 This is the first demonstration of a *role* of receptor transactivation in the phosphorylation of a [G protein coupled receptor] . Positive_regulation GPR132 EGFR 11502566 847502 We examined the *role* of ( EGFR ) tyrosine kinase activation in [G protein coupled receptor (GPCR)] agonist induced mitogenesis in Swiss 3T3 and Rat-1 cells . Positive_regulation GPR132 EGFR 18658095 2010728 ERK1/2 mediate wounding- and [G-protein coupled receptor] ligands *induced* activation via regulating ADAM17 and HB-EGF shedding . Positive_regulation GPR132 EGFR 19587094 2129445 [G protein coupled receptor (GPCR)] *activation* of has been reported to involve Src 's activation via a GPCR-beta-arrestin-Src complex . Positive_regulation GPR132 ETS1 18094067 1874934 Conversely , in the PHR , *increased* TH activity through a [G protein coupled receptor] , likely an atypical ET receptor or the ET ( C ) receptor , which stimulated the phosphoinositide and adenylyl cyclase pathways , as well as CaMK-II . Positive_regulation GPR132 ETS2 18094067 1874935 Conversely , in the PHR , *increased* TH activity through a [G protein coupled receptor] , likely an atypical ET receptor or the ET ( C ) receptor , which stimulated the phosphoinositide and adenylyl cyclase pathways , as well as CaMK-II . Positive_regulation GPR132 FLNA 16513120 1535777 Using short interfering RNA ( siRNA ) to selectively target the filamin A gene and silence its expression , we studied the *role* of in [G protein coupled receptor (GPCR)] signaling . Positive_regulation GPR132 GH1 15361691 1303842 Ghrelin and the synthetic *activate* a [G-protein coupled receptor] ( GHS-R ) originally cloned from the pituitary , but which is also expressed in the hypothalamus , in other areas of the brain and in numerous peripheral tissues . Positive_regulation GPR132 GNB1 16129667 1474361 *Activation* of a by an agonist stimulated [G-protein coupled receptor] requires the propagation of structural signals from the receptor binding interface to the guanine nucleotide binding pocket of the G-protein . Positive_regulation GPR132 GNB2L1 18088317 1862415 *regulates* the cell surface expression of the [G protein coupled receptor] for thromboxane A ( 2 ) . Positive_regulation GPR132 GNG2 16129667 1474362 *Activation* of a by an agonist stimulated [G-protein coupled receptor] requires the propagation of structural signals from the receptor binding interface to the guanine nucleotide binding pocket of the G-protein . Positive_regulation GPR132 GNRH1 23321696 2733379 Using a high-throughput ß-arrestin recruitment assay , we identified an orphan [G protein coupled receptor] ( GPR173 ) that was specifically *activated* by ( 1-5 ) . Positive_regulation GPR132 GRAP2 9915820 587219 These results demonstrate for the first time that apart from ERK , *activation* by a [G protein coupled receptor] can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation GPR132 GRK1 17971124 1858873 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Positive_regulation GPR132 GRK1 18056263 1852700 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Positive_regulation GPR132 GRK4 17971124 1858875 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Positive_regulation GPR132 GRK4 18056263 1852702 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Positive_regulation GPR132 GRK5 17971124 1858876 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Positive_regulation GPR132 GRK5 18056263 1852703 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Positive_regulation GPR132 GRK6 17971124 1858877 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Positive_regulation GPR132 GRK6 18056263 1852704 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Positive_regulation GPR132 GRK6 20799926 2336097 Lysophosphatidylcholines activate [G2A] *inducing* G ( ai ) ?1-/G ( aq/ ) 11- Ca² ( + ) flux , G ( ß? ) -Hck activation and recruitment in PMNs . Positive_regulation GPR132 GRK7 17971124 1858874 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Positive_regulation GPR132 GRK7 18056263 1852701 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Positive_regulation GPR132 HCK 20799926 2336098 Lysophosphatidylcholines activate [G2A] *inducing* G ( ai ) ?1-/G ( aq/ ) 11- Ca² ( + ) flux , G ( ß? ) <-Hck> activation and clathrin/ß-arrestin-1/GRK6 recruitment in PMNs . Positive_regulation GPR132 HSPG2 17077647 1650008 The inhibitor effect of dipyrone on IP accumulation may be due to direct inhibition of phospholipase C (PLC) or impairment of the *activation* of by [G protein coupled receptor (GPCR)] . Positive_regulation GPR132 HTN1 19652025 2150080 Activation of cells by *requires* a [G-protein coupled receptor] that activates the ERK1/2 pathway . Positive_regulation GPR132 HTN3 19652025 2150081 Activation of cells by *requires* a [G-protein coupled receptor] that activates the ERK1/2 pathway . Positive_regulation GPR132 IAPP 23966942 2832542 Both and Aß directly *activate* this [G protein coupled receptor] and trigger multiple common intracellular signal transduction pathways that can culminate in apoptotic cell death . Positive_regulation GPR132 IFNG 8456301 215459 Immunoglobulin isotype analysis revealed that is *necessary* for a normal antigen-specific immunoglobulin [G2a] response . Positive_regulation GPR132 IFNG 8769393 379106 SRIF was shown to inhibit *induced* immunoglobulin [G2a] ( lgG2a ) synthesis in murine schistosomiasis . Positive_regulation GPR132 IL8 12393391 1035175 Serum amyloid A *induces* secretion through a [G protein coupled receptor] , FPRL1/LXA4R . Positive_regulation GPR132 IL8 24164922 2882763 Transcriptome analyses revealed that Caco-2 BBE cells respond to stimulation with IL-8 supporting the hypothesis that *induces* [G protein coupled receptor] signalling . Positive_regulation GPR132 INS 15388645 1354036 Substitution of the C-terminal cytoplasmic tail of the beta2-adrenergic receptor on the beta1-adrenergic receptor enabled the chimeric [G protein coupled receptor] to be functionally and spatially *regulated* by . Positive_regulation GPR132 KRT13 16936773 1700077 *induces* the expression of several genes known to be upregulated in HHV8 transformed vascular endothelial cells , such as interleukin (IL)-6 , IL-8 , CXC ligand 3 (CXCL3) , orphan [G protein coupled receptor] ( RDC1 ) , cyclooxygenase-2 (COX-2) and dual-specificity phosphatase 5 (DUSP5) . Positive_regulation GPR132 LPA 11748189 898092 In this study we demonstrate that the OprI from Pseudomonas aeruginosa *induces* a long-term cellular ( gamma interferon [ IFN-gamma ] ) and humoral ( immunoglobulin [G2a] ) type 1 immune response against a truncated 32-kDa version ( COOHgp63 ) of the 63-kDa major cell surface glycoprotein gp63 . Positive_regulation GPR132 LPA 19679818 2180406 P2Y5 is a [G protein coupled receptor] that binds and is *activated* by . Positive_regulation GPR132 LPA 21454702 2427804 Cleavage was stimulated by phorbol ester ( 12-O-tetradecanoylphorbol-13-acetate ( TPA ) , a mimic of diacylglycerol and PKC activator ) , hypertonic stress , induced [G protein coupled receptor] *activation* , or by ionomycin induced intracellular calcium release . Positive_regulation GPR132 LPA 8489494 219237 *activates* a putative [G-protein coupled receptor] in responsive cells , but the natural source of exogenous LPA is unknown . Positive_regulation GPR132 MAPK1 16611986 1545496 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR132 MAPK10 16611986 1545497 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR132 MAPK11 16611986 1545498 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR132 MAPK12 16611986 1545499 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR132 MAPK13 16611986 1545500 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR132 MAPK14 16611986 1545501 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR132 MAPK15 16611986 1545495 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR132 MAPK3 16611986 1545502 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR132 MAPK4 16611986 1545503 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR132 MAPK6 16611986 1545504 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR132 MAPK7 16611986 1545505 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR132 MAPK8 16611986 1545506 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR132 MAPK9 16611986 1545507 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR132 MED1 18992245 1995970 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED1 7733903 302853 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED10 18992245 1995965 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED10 7733903 302848 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED11 18992245 1995968 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED11 7733903 302851 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED13 18992245 1995952 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED13 7733903 302835 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED13L 18992245 1995953 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED13L 7733903 302836 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED14 18992245 1995957 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED14 7733903 302840 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED15 18992245 1995946 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED15 7733903 302829 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED16 18992245 1995948 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED16 7733903 302831 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED17 18992245 1995959 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED17 7733903 302842 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED18 18992245 1995964 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED18 7733903 302847 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED19 18992245 1995967 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED19 7733903 302850 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED20 18992245 1995947 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED20 7733903 302830 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED21 18992245 1995944 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED21 7733903 302827 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED22 18992245 1995945 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED22 7733903 302828 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED23 18992245 1995958 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED23 7733903 302841 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED24 18992245 1995954 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED24 7733903 302837 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED25 18992245 1995966 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED25 7733903 302849 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED26 18992245 1995960 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED26 7733903 302843 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED27 18992245 1995961 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED27 7733903 302844 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED29 18992245 1995956 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED29 7733903 302839 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED30 18992245 1995955 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED30 7733903 302838 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED31 18992245 1995963 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED31 7733903 302846 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED4 18992245 1995949 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED4 7733903 302832 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED6 18992245 1995950 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED6 7733903 302833 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED7 18992245 1995962 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED7 7733903 302845 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 MED8 18992245 1995951 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 MED8 7733903 302834 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 NFKB1 11815436 907765 In this study , we examined the *role* of an ROS-sensitive transcriptional factor , , and a mitogen activated protein kinase kinase kinase , apoptosis signal regulating kinase 1 ( ASK1 ) , in [G-protein coupled receptor (GPCR)] agonist ( angiotensin II , endothelin-1 , phenylephrine ) -induced cardiac hypertrophy in isolated rat neonatal cardiomyocytes . Positive_regulation GPR132 NFKB1 21159881 2384844 Phosphorylation and polyubiquitination of transforming growth factor beta activated kinase 1 are necessary for *activation* of by the Kaposi 's sarcoma associated herpesvirus [G protein coupled receptor] . Positive_regulation GPR132 NPS 15731503 1377604 *activates* an orphan [G protein coupled receptor] that is expressed throughout the central nervous system , including brain centers that regulate sleep/wakefulness and anxiety . Positive_regulation GPR132 NPS 17613937 1768802 *activates* its cognate [G protein coupled receptor] at low nanomolar agonist concentrations and induces elevation of intracellular Ca2+ and cAMP , therefore acting as an excitatory transmitter . Positive_regulation GPR132 OPA1 18992245 1995969 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR132 OPA1 7733903 302852 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR132 PAK1 14695200 1180062 *Activation* of factor kappaB signaling by Kaposi 's sarcoma associated herpes virus [G protein coupled receptor] during cellular transformation . Positive_regulation GPR132 PHKA2 14963038 1235387 is a member of the focal adhesion kinase family and can be *activated* by c-Src , epidermal growth factor receptor (EGFR) , Janus kinase 1 , tyrosine kinases , and [G-protein coupled receptor] signaling . Positive_regulation GPR132 PHKA2 15911746 1420136 Role of the actin cytoskeleton in [G-protein coupled receptor] *activation* of and paxillin in vascular smooth muscle . Positive_regulation GPR132 PI3 10187765 602530 Furthermore , we show that the p85 regulatory subunit is required for *activation* of activity by this [G protein coupled receptor] . Positive_regulation GPR132 PIK3CB 18594509 1946999 However , the kinase activity of was *required* for [G-protein coupled receptor] signalling triggered by lysophosphatidic acid and had a function in oncogenic transformation . Positive_regulation GPR132 PITRM1 24732013 2936099 The protease activated receptor 1 (PAR1) is a [G-protein coupled receptor] that is irreversibly *activated* by either thrombin or . Positive_regulation GPR132 PRKACB 20826718 2352349 We show here that Gs-linked [G protein coupled receptor] *activation* of cAMP dependent plays an important role in regulating the switch between endothelial cell adhesion and migration by activating C-terminal Src kinase , leading to inhibition of pp60Src . Positive_regulation GPR132 PRKACG 20826718 2352350 We show here that Gs-linked [G protein coupled receptor] *activation* of cAMP dependent plays an important role in regulating the switch between endothelial cell adhesion and migration by activating C-terminal Src kinase , leading to inhibition of pp60Src . Positive_regulation GPR132 PRKAR1A 20826718 2352351 We show here that Gs-linked [G protein coupled receptor] *activation* of cAMP dependent plays an important role in regulating the switch between endothelial cell adhesion and migration by activating C-terminal Src kinase , leading to inhibition of pp60Src . Positive_regulation GPR132 PRKAR1B 20826718 2352352 We show here that Gs-linked [G protein coupled receptor] *activation* of cAMP dependent plays an important role in regulating the switch between endothelial cell adhesion and migration by activating C-terminal Src kinase , leading to inhibition of pp60Src . Positive_regulation GPR132 PRKAR2A 20826718 2352353 We show here that Gs-linked [G protein coupled receptor] *activation* of cAMP dependent plays an important role in regulating the switch between endothelial cell adhesion and migration by activating C-terminal Src kinase , leading to inhibition of pp60Src . Positive_regulation GPR132 PRKAR2B 20826718 2352354 We show here that Gs-linked [G protein coupled receptor] *activation* of cAMP dependent plays an important role in regulating the switch between endothelial cell adhesion and migration by activating C-terminal Src kinase , leading to inhibition of pp60Src . Positive_regulation GPR132 PTGS2 17868457 1810539 Kaposi 's sarcoma associated herpesvirus [G-protein coupled receptor] *activation* of in vascular endothelial cells . Positive_regulation GPR132 PTGS2 18515110 1928471 is rapidly *induced* by angiotensin (Ang)-II in the non-tumorigenic , rat intestinal epithelial cell line , IEC-18 , through its [G-protein coupled receptor] , AT1R . Positive_regulation GPR132 PTH 10438471 634738 A [G protein coupled receptor] from zebrafish is *activated* by human and not by human or teleost parathyroid hormone related peptide . Positive_regulation GPR132 PTH 20172855 2236509 The parathyroid hormone receptor ( PTH1R ) is a class B [G protein coupled receptor] that is *activated* by parathyroid hormone (PTH) and . Positive_regulation GPR132 PTHLH 15515174 1342927 *Activation* of this [G-protein coupled receptor] by has been shown to regulate chondrogenesis in a manner that attenuates chondrocyte hypertrophy . Positive_regulation GPR132 PTK2B 10542211 563586 Kaposi 's sarcoma associated herpesvirus encoded [G protein coupled receptor] activation of c-jun amino-terminal kinase/stress activated protein kinase and lyn kinase is *mediated* by tyrosine kinase 2 . Positive_regulation GPR132 PXN 15911746 1420137 Role of the actin cytoskeleton in [G-protein coupled receptor] *activation* of PYK2 and in vascular smooth muscle . Positive_regulation GPR132 RELA 11815436 907766 In this study , we examined the *role* of an ROS-sensitive transcriptional factor , , and a mitogen activated protein kinase kinase kinase , apoptosis signal regulating kinase 1 ( ASK1 ) , in [G-protein coupled receptor (GPCR)] agonist ( angiotensin II , endothelin-1 , phenylephrine ) -induced cardiac hypertrophy in isolated rat neonatal cardiomyocytes . Positive_regulation GPR132 RELA 21159881 2384845 Phosphorylation and polyubiquitination of transforming growth factor beta activated kinase 1 are necessary for *activation* of by the Kaposi 's sarcoma associated herpesvirus [G protein coupled receptor] . Positive_regulation GPR132 RGS18 17074726 1638046 Our results suggest that [G-protein coupled receptor] mediated signalling in platelet may be *regulated* mainly by , 16 , 10 , 6 , and LARG . Positive_regulation GPR132 RGS2 19427970 2076819 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR132 RGS3 9182581 434707 A truncated form of negatively *regulates* [G protein coupled receptor] stimulation of adenylyl cyclase and phosphoinositide phospholipase C . Positive_regulation GPR132 RHO 10891074 710697 [G protein coupled receptor] *activation* : analysis of a highly constrained , `` straitjacketed '' . Positive_regulation GPR132 RHOA 21167820 2385306 This suggests the involvement of a [G-protein coupled receptor] and *activation* of . Positive_regulation GPR132 RLN3 17132825 1700898 In the rat , binds and *activates* both relaxin family peptide receptor 1 , which also binds relaxin-1 , and a previously orphaned [G protein coupled receptor] , RXFP3 . Positive_regulation GPR132 RLN3 24711793 2931831 is a newly discovered neuropeptide that binds , and *activates* the [G-protein coupled receptor] , RXFP3 . Positive_regulation GPR132 SAA1 12393391 1035172 *induces* IL-8 secretion through a [G protein coupled receptor] , FPRL1/LXA4R . Positive_regulation GPR132 SAA2 12393391 1035173 *induces* IL-8 secretion through a [G protein coupled receptor] , FPRL1/LXA4R . Positive_regulation GPR132 SAA4 12393391 1035174 *induces* IL-8 secretion through a [G protein coupled receptor] , FPRL1/LXA4R . Positive_regulation GPR132 SERPINE1 15808835 1391437 Role of c-Jun NH2-terminal kinase in [G-protein coupled receptor] agonist *induced* cardiac expression . Positive_regulation GPR132 SFTPC 10571530 568556 The effects of could be *mediated* , in part , by activation of a [G protein coupled receptor] and a MAPK signaling cascade . Positive_regulation GPR132 SFTPC 16490345 1597756 The phospholipase C (PLC) inhibitor U 73122 potently attenuated the effect of SPC , suggesting that effects of were *mediated* by a [G protein coupled receptor] . Positive_regulation GPR132 SLC9A1 15494214 1354765 The regulation of NHE1 by growth factors involves the Ras-extracellular signal regulated kinase ( ERK ) pathway , however , the mechanism for [G protein coupled receptor (GPCR)] *activation* of is not well established . Positive_regulation GPR132 SPP1 8567663 349632 Here , we present evidence that *activates* a [G protein coupled receptor] in the plasma membrane of various cells , leading to increase in cytoplasmic Ca2+ concentration ([Ca2+]i) , inhibition of adenylyl cyclase , and opening of G protein regulated potassium channels . Positive_regulation GPR132 SPP2 8567663 349633 Here , we present evidence that *activates* a [G protein coupled receptor] in the plasma membrane of various cells , leading to increase in cytoplasmic Ca2+ concentration ([Ca2+]i) , inhibition of adenylyl cyclase , and opening of G protein regulated potassium channels . Positive_regulation GPR132 SST 8806621 382329 *Role* of in modulating [G protein coupled receptor] signaling . Positive_regulation GPR132 TAS1R2 20493823 2283543 In mammals , sweet taste perception is *mediated* by the heterodimeric [G-protein coupled receptor] , . Positive_regulation GPR132 TAS1R3 20493823 2283544 In mammals , sweet taste perception is *mediated* by the heterodimeric [G-protein coupled receptor] , . Positive_regulation GPR132 TRH 20352046 2231260 T ( 3 ) negatively regulates TSHalpha gene expression via thyroid hormone receptors ( TRs ) which belong to the nuclear hormone receptor superfamily , whereas positively *regulates* via the TRH receptor , a [G protein coupled receptor] . Positive_regulation GPR132 UTS2 22563490 2596228 The peptide *activates* a [G protein coupled receptor] named UT , and mediates potent vasoconstriction or vasodilation in mammalian vasculature . Positive_regulation GPR132 WAS 10787386 688450 The recent identification of a [G-protein coupled receptor] that was *activated* by , the major psychoactive component of marijuana , led to the discovery of endogenous agonists . Positive_regulation GPR132 YME1L1 15823563 1393932 In an effort to identify potential PAMP receptor ( s ) , we found that a human [G-protein coupled receptor] , MrgX2 , was specifically *activated* by . Positive_regulation GPR133 RGS2 19427970 2076834 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR135 RGS2 19427970 2076835 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR137 RGS2 19427970 2076853 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR139 RGS2 19427970 2076836 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR141 RGS2 19427970 2076837 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR142 RGS2 19427970 2076838 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR143 RGS2 19427970 2076839 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR144 RGS2 19427970 2076824 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR146 RGS2 19427970 2076841 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR148 RGS2 19427970 2076845 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR149 RGS2 19427970 2076847 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR15 IL1B 12555203 1051624 Moreover , TNFalpha and significantly *increase* [BOB/GPR15] , CCR2 , and V28/CX3CR1 mRNA levels in both models . Positive_regulation GPR15 RGS2 19427970 2076862 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR15 TNF 12555203 1051623 Moreover , and IL-1beta significantly *increase* [BOB/GPR15] , CCR2 , and V28/CX3CR1 mRNA levels in both models . Positive_regulation GPR150 RGS2 19427970 2076848 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR151 RGS2 19427970 2076846 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR152 RGS2 19427970 2076844 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR153 RGS2 19427970 2076843 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR155 RGS2 19427970 2076842 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR156 RGS2 19427970 2076840 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR157 RGS2 19427970 2076849 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR158 RGS2 19427970 2076850 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR160 RGS2 19427970 2076851 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR161 RGS2 19427970 2076852 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR162 RGS2 19427970 2076817 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR17 RGS2 19427970 2076863 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR171 RGS2 19427970 2076855 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR173 RGS2 19427970 2076823 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR174 RGS2 19427970 2076856 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR176 RGS2 19427970 2076859 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR179 RGS2 19427970 2076858 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR18 RGS2 19427970 2076864 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR180 RGS2 19427970 2076854 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR182 RGS2 19427970 2076811 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR183 RGS2 19427970 2076857 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR19 RGS2 19427970 2076865 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR20 RGS2 19427970 2076866 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR21 RGS2 19427970 2076867 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR22 GPR115 18539757 1945609 Myocardial expression , signaling , and function of [GPR22] : a protective *role* for an orphan . Positive_regulation GPR22 GPR132 18539757 1945598 Myocardial expression , signaling , and function of [GPR22] : a protective *role* for an orphan . Positive_regulation GPR22 GPR87 18539757 1945678 Myocardial expression , signaling , and function of [GPR22] : a protective *role* for an orphan . Positive_regulation GPR22 RGS2 19427970 2076868 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR25 RGS2 19427970 2076869 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR26 RGS2 19427970 2076870 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR27 RGS2 19427970 2076871 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR3 RGS2 19427970 2076872 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR31 RGS2 19427970 2076873 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR32 RGS2 19427970 2076874 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR33 RGS2 19427970 2076875 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR34 RGS2 19427970 2076876 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR35 RGS2 19427970 2076877 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR36 RGS2 19427970 2076878 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR37 RGS2 19427970 2076879 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR39 GPR115 18337590 1912304 Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory *role* of , [GPR39] . Positive_regulation GPR39 GPR132 18337590 1912293 Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory *role* of , [GPR39] . Positive_regulation GPR39 GPR87 18337590 1912373 Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory *role* of , [GPR39] . Positive_regulation GPR39 RGS2 19427970 2076880 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR4 RGS2 19427970 2076881 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR42 RGS2 19427970 2076882 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR45 RGS2 19427970 2076883 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR50 RGS2 19427970 2076884 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR52 RGS2 19427970 2076885 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR55 RGS2 19427970 2076886 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR56 RGS2 19427970 2076887 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR6 RGS2 19427970 2076888 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR61 RGS2 19427970 2076808 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR62 RGS2 19427970 2076809 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR63 RGS2 19427970 2076810 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR64 RGS2 19427970 2076889 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR65 RGS2 19427970 2076890 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR68 RGS2 19427970 2076891 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR75 RGS2 19427970 2076893 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR78 RGS2 19427970 2076894 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR79 RGS2 19427970 2076895 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR82 RGS2 19427970 2076896 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR83 RGS2 19427970 2076892 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR84 RGS2 19427970 2076897 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR84 TNF 17390309 1727748 Moreover , when injected intracerebrally or added to microglial cultures , recombinant *stimulates* [GPR84] expression through a dexamethasone-insensitive mechanism . Positive_regulation GPR85 RGS2 19427970 2076898 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR87 ABL1 16291747 1510456 We performed in vitro kinase activity assays and show that also leads to increased p110gamma activity and that this activation *requires* both [G protein coupled receptor] and Ras signaling . Positive_regulation GPR87 ADCYAP1 17680996 1805508 These results therefore identify the *induced* translocation of its [G-protein coupled receptor] into caveolae , where both AC and the regulating G-proteins reside , as the key molecular event in activating AC and inducing cAMP mediated differentiation of PC12 cells . Positive_regulation GPR87 ADCYAP1 23284775 2711618 PAC1 is PACAP ( pituitary adenylate cyclase activating polypeptide ) preferring receptor belonging to class B [G protein coupled receptor (GPCR)] *mediating* the most effects of . Positive_regulation GPR87 ADRBK1 19815545 2164357 Our results suggest a novel mechanism by which negatively *regulates* [G protein coupled receptor] signaling in a manner that is independent of receptor phosphorylation . Positive_regulation GPR87 ANGPT2 18515110 1928630 Cyclooxygenase-2 (COX-2) is rapidly *induced* by in the non-tumorigenic , rat intestinal epithelial cell line , IEC-18 , through its [G-protein coupled receptor] , AT1R . Positive_regulation GPR87 ANGPT2 7699989 288299 The physiologic effects of are *mediated* by a [G-protein coupled receptor] , termed AT1 , which activates phospholipase C . Positive_regulation GPR87 ANGPT2 8088922 271578 These findings suggest that *induces* the phosphorylation of its own [G protein coupled receptor] through both serine and tyrosine kinases and raise the possibility that phosphorylation of the AT1AR is an important regulator of receptor function . Positive_regulation GPR87 ANGPT2 9421435 481083 In view of this unique property and the presence of putative nuclear localization signal ( NLS ) consensus sequence in the AT1 receptor , this study was conducted to investigate the hypothesis that would *induce* nuclear sequestration of this [G protein coupled receptor] and that the sequestration may have implications on Ang II-induced expression of NET and TH genes . Positive_regulation GPR87 ANXA6 9299479 453574 Wortmannin-sensitive *activation* of and MAP-kinase by the [G protein coupled receptor] , G/CCKB . Positive_regulation GPR87 BCR 16291747 1510453 We performed in vitro kinase activity assays and show that also leads to increased p110gamma activity and that this activation *requires* both [G protein coupled receptor] and Ras signaling . Positive_regulation GPR87 CALM3 10496966 647334 The first mechanism is based on recent in vitro studies demonstrating that [G protein coupled receptor kinase (GRK)] activity , the protein kinase responsible for beta(2)-adrenergic receptor homologous phosphorylation and desensitization , may be *regulated* by and membrane phosphatidylinositol 4 , 5-bisphosphate . Positive_regulation GPR87 CAT 11751593 898571 [GAL4/PR-B] and VP16/PR-B *induced* ( approximately 3- to 4-fold ) activity in a progesterone dependent manner , suggesting PR-dimer formation . Positive_regulation GPR87 CCL2 23877010 2839401 The chemokine receptor CCR2 is a [G protein coupled receptor] that is *activated* primarily by the endogenous . Positive_regulation GPR87 CD79A 16291747 1510454 We performed in vitro kinase activity assays and show that also leads to increased p110gamma activity and that this activation *requires* both [G protein coupled receptor] and Ras signaling . Positive_regulation GPR87 CD79B 16291747 1510455 We performed in vitro kinase activity assays and show that also leads to increased p110gamma activity and that this activation *requires* both [G protein coupled receptor] and Ras signaling . Positive_regulation GPR87 CSK 16501257 1541538 *Role* of tyrosine kinase in [G protein coupled receptor-] and receptor tyrosine kinase induced fibroblast cell migration . Positive_regulation GPR87 CSK 8702633 375717 *Role* of in [G protein coupled receptor-] and Gbetagamma subunit mediated activation of mitogen activated protein kinases . Positive_regulation GPR87 CXCR4 15292258 1303107 Its numerous biological effects are *mediated* by a specific [G protein coupled receptor] , . Positive_regulation GPR87 EGF 12880866 1115956 This is the first demonstration of a *role* of receptor transactivation in the phosphorylation of a [G protein coupled receptor] . Positive_regulation GPR87 EGFR 11502566 847582 We examined the *role* of ( EGFR ) tyrosine kinase activation in [G protein coupled receptor (GPCR)] agonist induced mitogenesis in Swiss 3T3 and Rat-1 cells . Positive_regulation GPR87 EGFR 18658095 2010902 ERK1/2 mediate wounding- and [G-protein coupled receptor] ligands *induced* activation via regulating ADAM17 and HB-EGF shedding . Positive_regulation GPR87 EGFR 19587094 2129525 [G protein coupled receptor (GPCR)] *activation* of has been reported to involve Src 's activation via a GPCR-beta-arrestin-Src complex . Positive_regulation GPR87 ETS1 18094067 1875094 Conversely , in the PHR , *increased* TH activity through a [G protein coupled receptor] , likely an atypical ET receptor or the ET ( C ) receptor , which stimulated the phosphoinositide and adenylyl cyclase pathways , as well as CaMK-II . Positive_regulation GPR87 ETS2 18094067 1875095 Conversely , in the PHR , *increased* TH activity through a [G protein coupled receptor] , likely an atypical ET receptor or the ET ( C ) receptor , which stimulated the phosphoinositide and adenylyl cyclase pathways , as well as CaMK-II . Positive_regulation GPR87 FLNA 16513120 1535857 Using short interfering RNA ( siRNA ) to selectively target the filamin A gene and silence its expression , we studied the *role* of in [G protein coupled receptor (GPCR)] signaling . Positive_regulation GPR87 GH1 15361691 1303922 Ghrelin and the synthetic *activate* a [G-protein coupled receptor] ( GHS-R ) originally cloned from the pituitary , but which is also expressed in the hypothalamus , in other areas of the brain and in numerous peripheral tissues . Positive_regulation GPR87 GNB1 16129667 1474707 *Activation* of a by an agonist stimulated [G-protein coupled receptor] requires the propagation of structural signals from the receptor binding interface to the guanine nucleotide binding pocket of the G-protein . Positive_regulation GPR87 GNB2L1 18088317 1862495 *regulates* the cell surface expression of the [G protein coupled receptor] for thromboxane A ( 2 ) . Positive_regulation GPR87 GNG2 16129667 1474708 *Activation* of a by an agonist stimulated [G-protein coupled receptor] requires the propagation of structural signals from the receptor binding interface to the guanine nucleotide binding pocket of the G-protein . Positive_regulation GPR87 GNRH1 23321696 2733459 Using a high-throughput ß-arrestin recruitment assay , we identified an orphan [G protein coupled receptor] ( GPR173 ) that was specifically *activated* by ( 1-5 ) . Positive_regulation GPR87 GRAP2 9915820 587393 These results demonstrate for the first time that apart from ERK , *activation* by a [G protein coupled receptor] can be attenuated by an RGS protein and provide further evidence for the specificity of RGS function in G protein signaling pathways . Positive_regulation GPR87 GRK1 17971124 1859273 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Positive_regulation GPR87 GRK1 18056263 1853100 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Positive_regulation GPR87 GRK4 17971124 1859275 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Positive_regulation GPR87 GRK4 18056263 1853102 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Positive_regulation GPR87 GRK5 17971124 1859276 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Positive_regulation GPR87 GRK5 18056263 1853103 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Positive_regulation GPR87 GRK6 17971124 1859277 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Positive_regulation GPR87 GRK6 18056263 1853104 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Positive_regulation GPR87 GRK7 17971124 1859274 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Positive_regulation GPR87 GRK7 18056263 1853101 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Positive_regulation GPR87 HSPG2 17077647 1650088 The inhibitor effect of dipyrone on IP accumulation may be due to direct inhibition of phospholipase C (PLC) or impairment of the *activation* of by [G protein coupled receptor (GPCR)] . Positive_regulation GPR87 HTN1 19652025 2150240 Activation of cells by *requires* a [G-protein coupled receptor] that activates the ERK1/2 pathway . Positive_regulation GPR87 HTN3 19652025 2150241 Activation of cells by *requires* a [G-protein coupled receptor] that activates the ERK1/2 pathway . Positive_regulation GPR87 IAPP 23966942 2832622 Both and Aß directly *activate* this [G protein coupled receptor] and trigger multiple common intracellular signal transduction pathways that can culminate in apoptotic cell death . Positive_regulation GPR87 IL8 12393391 1035495 Serum amyloid A *induces* secretion through a [G protein coupled receptor] , FPRL1/LXA4R . Positive_regulation GPR87 IL8 24164922 2882843 Transcriptome analyses revealed that Caco-2 BBE cells respond to stimulation with IL-8 supporting the hypothesis that *induces* [G protein coupled receptor] signalling . Positive_regulation GPR87 INS 15388645 1354116 Substitution of the C-terminal cytoplasmic tail of the beta2-adrenergic receptor on the beta1-adrenergic receptor enabled the chimeric [G protein coupled receptor] to be functionally and spatially *regulated* by . Positive_regulation GPR87 KRT13 16936773 1700158 *induces* the expression of several genes known to be upregulated in HHV8 transformed vascular endothelial cells , such as interleukin (IL)-6 , IL-8 , CXC ligand 3 (CXCL3) , orphan [G protein coupled receptor] ( RDC1 ) , cyclooxygenase-2 (COX-2) and dual-specificity phosphatase 5 (DUSP5) . Positive_regulation GPR87 LPA 19679818 2180486 P2Y5 is a [G protein coupled receptor] that binds and is *activated* by . Positive_regulation GPR87 LPA 21454702 2427884 Cleavage was stimulated by phorbol ester ( 12-O-tetradecanoylphorbol-13-acetate ( TPA ) , a mimic of diacylglycerol and PKC activator ) , hypertonic stress , *induced* [G protein coupled receptor] activation , or by ionomycin induced intracellular calcium release . Positive_regulation GPR87 LPA 23831392 2834621 We have previously reported that an orphan G protein coupled receptor [GPR87] was *activated* by and that it induced an increase in the intracellular Ca ( 2+ ) levels in the CHO cells genetically engineered to express GPR87-Ga16 fusion protein . Positive_regulation GPR87 LPA 8489494 219317 *activates* a putative [G-protein coupled receptor] in responsive cells , but the natural source of exogenous LPA is unknown . Positive_regulation GPR87 MAPK1 16611986 1546536 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR87 MAPK10 16611986 1546537 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR87 MAPK11 16611986 1546538 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR87 MAPK12 16611986 1546539 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR87 MAPK13 16611986 1546540 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR87 MAPK14 16611986 1546541 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR87 MAPK15 16611986 1546535 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR87 MAPK3 16611986 1546542 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR87 MAPK4 16611986 1546543 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR87 MAPK6 16611986 1546544 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR87 MAPK7 16611986 1546545 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR87 MAPK8 16611986 1546546 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR87 MAPK9 16611986 1546547 beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for [G protein coupled receptor] *activation* of . Positive_regulation GPR87 MED1 18992245 1998130 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED1 7733903 305013 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED10 18992245 1998125 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED10 7733903 305008 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED11 18992245 1998128 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED11 7733903 305011 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED13 18992245 1998112 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED13 7733903 304995 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED13L 18992245 1998113 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED13L 7733903 304996 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED14 18992245 1998117 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED14 7733903 305000 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED15 18992245 1998106 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED15 7733903 304989 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED16 18992245 1998108 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED16 7733903 304991 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED17 18992245 1998119 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED17 7733903 305002 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED18 18992245 1998124 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED18 7733903 305007 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED19 18992245 1998127 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED19 7733903 305010 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED20 18992245 1998107 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED20 7733903 304990 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED21 18992245 1998104 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED21 7733903 304987 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED22 18992245 1998105 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED22 7733903 304988 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED23 18992245 1998118 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED23 7733903 305001 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED24 18992245 1998114 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED24 7733903 304997 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED25 18992245 1998126 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED25 7733903 305009 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED26 18992245 1998120 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED26 7733903 305003 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED27 18992245 1998121 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED27 7733903 305004 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED29 18992245 1998116 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED29 7733903 304999 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED30 18992245 1998115 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED30 7733903 304998 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED31 18992245 1998123 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED31 7733903 305006 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED4 18992245 1998109 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED4 7733903 304992 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED6 18992245 1998110 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED6 7733903 304993 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED7 18992245 1998122 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED7 7733903 305005 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 MED8 18992245 1998111 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 MED8 7733903 304994 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 NFKB1 11815436 907925 In this study , we examined the *role* of an ROS-sensitive transcriptional factor , , and a mitogen activated protein kinase kinase kinase , apoptosis signal regulating kinase 1 ( ASK1 ) , in [G-protein coupled receptor (GPCR)] agonist ( angiotensin II , endothelin-1 , phenylephrine ) -induced cardiac hypertrophy in isolated rat neonatal cardiomyocytes . Positive_regulation GPR87 NFKB1 21159881 2385004 Phosphorylation and polyubiquitination of transforming growth factor beta activated kinase 1 are necessary for *activation* of by the Kaposi 's sarcoma associated herpesvirus [G protein coupled receptor] . Positive_regulation GPR87 NPS 15731503 1377684 *activates* an orphan [G protein coupled receptor] that is expressed throughout the central nervous system , including brain centers that regulate sleep/wakefulness and anxiety . Positive_regulation GPR87 NPS 17613937 1768882 *activates* its cognate [G protein coupled receptor] at low nanomolar agonist concentrations and induces elevation of intracellular Ca2+ and cAMP , therefore acting as an excitatory transmitter . Positive_regulation GPR87 OPA1 18992245 1998129 Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory induced [G-protein coupled receptor] *activation* . Positive_regulation GPR87 OPA1 7733903 305012 Lysophosphatidic acid ( LPA; 1-acyl-sn-glycero-3-phosphate ) is a platelet derived lipid that *activates* its own [G-protein coupled receptor] to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types . Positive_regulation GPR87 PAK1 14695200 1180142 *Activation* of factor kappaB signaling by Kaposi 's sarcoma associated herpes virus [G protein coupled receptor] during cellular transformation . Positive_regulation GPR87 PHKA2 14963038 1235467 is a member of the focal adhesion kinase family and can be *activated* by c-Src , epidermal growth factor receptor (EGFR) , Janus kinase 1 , tyrosine kinases , and [G-protein coupled receptor] signaling . Positive_regulation GPR87 PHKA2 15911746 1420296 Role of the actin cytoskeleton in [G-protein coupled receptor] *activation* of and paxillin in vascular smooth muscle . Positive_regulation GPR87 PI3 10187765 602610 Furthermore , we show that the p85 regulatory subunit is required for *activation* of activity by this [G protein coupled receptor] . Positive_regulation GPR87 PIK3CB 18594509 1947079 However , the kinase activity of was *required* for [G-protein coupled receptor] signalling triggered by lysophosphatidic acid and had a function in oncogenic transformation . Positive_regulation GPR87 PITRM1 24732013 2936179 The protease activated receptor 1 (PAR1) is a [G-protein coupled receptor] that is irreversibly *activated* by either thrombin or . Positive_regulation GPR87 PRKACB 20826718 2352829 We show here that Gs-linked [G protein coupled receptor] *activation* of cAMP dependent plays an important role in regulating the switch between endothelial cell adhesion and migration by activating C-terminal Src kinase , leading to inhibition of pp60Src . Positive_regulation GPR87 PRKACG 20826718 2352830 We show here that Gs-linked [G protein coupled receptor] *activation* of cAMP dependent plays an important role in regulating the switch between endothelial cell adhesion and migration by activating C-terminal Src kinase , leading to inhibition of pp60Src . Positive_regulation GPR87 PRKAR1A 20826718 2352831 We show here that Gs-linked [G protein coupled receptor] *activation* of cAMP dependent plays an important role in regulating the switch between endothelial cell adhesion and migration by activating C-terminal Src kinase , leading to inhibition of pp60Src . Positive_regulation GPR87 PRKAR1B 20826718 2352832 We show here that Gs-linked [G protein coupled receptor] *activation* of cAMP dependent plays an important role in regulating the switch between endothelial cell adhesion and migration by activating C-terminal Src kinase , leading to inhibition of pp60Src . Positive_regulation GPR87 PRKAR2A 20826718 2352833 We show here that Gs-linked [G protein coupled receptor] *activation* of cAMP dependent plays an important role in regulating the switch between endothelial cell adhesion and migration by activating C-terminal Src kinase , leading to inhibition of pp60Src . Positive_regulation GPR87 PRKAR2B 20826718 2352834 We show here that Gs-linked [G protein coupled receptor] *activation* of cAMP dependent plays an important role in regulating the switch between endothelial cell adhesion and migration by activating C-terminal Src kinase , leading to inhibition of pp60Src . Positive_regulation GPR87 PTGS2 17868457 1810619 Kaposi 's sarcoma associated herpesvirus [G-protein coupled receptor] *activation* of in vascular endothelial cells . Positive_regulation GPR87 PTGS2 18515110 1928631 is rapidly *induced* by angiotensin (Ang)-II in the non-tumorigenic , rat intestinal epithelial cell line , IEC-18 , through its [G-protein coupled receptor] , AT1R . Positive_regulation GPR87 PTH 10438471 634818 A [G protein coupled receptor] from zebrafish is *activated* by human and not by human or teleost parathyroid hormone related peptide . Positive_regulation GPR87 PTH 20172855 2236589 The parathyroid hormone receptor ( PTH1R ) is a class B [G protein coupled receptor] that is *activated* by parathyroid hormone (PTH) and . Positive_regulation GPR87 PTHLH 15515174 1343007 *Activation* of this [G-protein coupled receptor] by has been shown to regulate chondrogenesis in a manner that attenuates chondrocyte hypertrophy . Positive_regulation GPR87 PTK2B 10542211 563666 Kaposi 's sarcoma associated herpesvirus encoded [G protein coupled receptor] activation of c-jun amino-terminal kinase/stress activated protein kinase and lyn kinase is *mediated* by related adhesion focal tyrosine . Positive_regulation GPR87 PXN 15911746 1420297 Role of the actin cytoskeleton in [G-protein coupled receptor] *activation* of PYK2 and in vascular smooth muscle . Positive_regulation GPR87 RELA 11815436 907926 In this study , we examined the *role* of an ROS-sensitive transcriptional factor , , and a mitogen activated protein kinase kinase kinase , apoptosis signal regulating kinase 1 ( ASK1 ) , in [G-protein coupled receptor (GPCR)] agonist ( angiotensin II , endothelin-1 , phenylephrine ) -induced cardiac hypertrophy in isolated rat neonatal cardiomyocytes . Positive_regulation GPR87 RELA 21159881 2385005 Phosphorylation and polyubiquitination of transforming growth factor beta activated kinase 1 are necessary for *activation* of by the Kaposi 's sarcoma associated herpesvirus [G protein coupled receptor] . Positive_regulation GPR87 RGS18 17074726 1638126 Our results suggest that [G-protein coupled receptor] mediated signalling in platelet may be *regulated* mainly by , 16 , 10 , 6 , and LARG . Positive_regulation GPR87 RGS2 19427970 2076899 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR87 RGS3 9182581 434787 A truncated form of negatively *regulates* [G protein coupled receptor] stimulation of adenylyl cyclase and phosphoinositide phospholipase C . Positive_regulation GPR87 RHO 10891074 710777 [G protein coupled receptor] *activation* : analysis of a highly constrained , `` straitjacketed '' . Positive_regulation GPR87 RHOA 21167820 2385386 This suggests the involvement of a [G-protein coupled receptor] and *activation* of . Positive_regulation GPR87 RLN3 17132825 1700979 In the rat , binds and *activates* both relaxin family peptide receptor 1 , which also binds relaxin-1 , and a previously orphaned [G protein coupled receptor] , RXFP3 . Positive_regulation GPR87 RLN3 24711793 2931911 is a newly discovered neuropeptide that binds , and *activates* the [G-protein coupled receptor] , RXFP3 . Positive_regulation GPR87 SAA1 12393391 1035492 *induces* IL-8 secretion through a [G protein coupled receptor] , FPRL1/LXA4R . Positive_regulation GPR87 SAA2 12393391 1035493 *induces* IL-8 secretion through a [G protein coupled receptor] , FPRL1/LXA4R . Positive_regulation GPR87 SAA4 12393391 1035494 *induces* IL-8 secretion through a [G protein coupled receptor] , FPRL1/LXA4R . Positive_regulation GPR87 SERPINE1 15808835 1391517 Role of c-Jun NH2-terminal kinase in [G-protein coupled receptor] agonist *induced* cardiac expression . Positive_regulation GPR87 SFTPC 10571530 568636 The effects of could be *mediated* , in part , by activation of a [G protein coupled receptor] and a MAPK signaling cascade . Positive_regulation GPR87 SFTPC 16490345 1597836 The phospholipase C (PLC) inhibitor U 73122 potently attenuated the effect of SPC , suggesting that effects of were *mediated* by a [G protein coupled receptor] . Positive_regulation GPR87 SLC9A1 15494214 1354845 The regulation of NHE1 by growth factors involves the Ras-extracellular signal regulated kinase ( ERK ) pathway , however , the mechanism for [G protein coupled receptor (GPCR)] *activation* of is not well established . Positive_regulation GPR87 SPP1 8567663 349792 Here , we present evidence that *activates* a [G protein coupled receptor] in the plasma membrane of various cells , leading to increase in cytoplasmic Ca2+ concentration ([Ca2+]i) , inhibition of adenylyl cyclase , and opening of G protein regulated potassium channels . Positive_regulation GPR87 SPP2 8567663 349793 Here , we present evidence that *activates* a [G protein coupled receptor] in the plasma membrane of various cells , leading to increase in cytoplasmic Ca2+ concentration ([Ca2+]i) , inhibition of adenylyl cyclase , and opening of G protein regulated potassium channels . Positive_regulation GPR87 SST 8806621 382409 *Role* of in modulating [G protein coupled receptor] signaling . Positive_regulation GPR87 TAS1R2 20493823 2283703 In mammals , sweet taste perception is *mediated* by the heterodimeric [G-protein coupled receptor] , . Positive_regulation GPR87 TAS1R3 20493823 2283704 In mammals , sweet taste perception is *mediated* by the heterodimeric [G-protein coupled receptor] , . Positive_regulation GPR87 TP53 19602589 2112104 Here , we found that [G protein coupled receptor 87 (GPR87)] was *up-regulated* by and by DNA damage in a p53 dependent manner . Positive_regulation GPR87 TRH 20352046 2231340 T ( 3 ) negatively regulates TSHalpha gene expression via thyroid hormone receptors ( TRs ) which belong to the nuclear hormone receptor superfamily , whereas positively *regulates* via the TRH receptor , a [G protein coupled receptor] . Positive_regulation GPR87 UTS2 22563490 2596308 The peptide *activates* a [G protein coupled receptor] named UT , and mediates potent vasoconstriction or vasodilation in mammalian vasculature . Positive_regulation GPR87 WAS 10787386 688530 The recent identification of a [G-protein coupled receptor] that was *activated* by , the major psychoactive component of marijuana , led to the discovery of endogenous agonists . Positive_regulation GPR87 YME1L1 15823563 1394012 In an effort to identify potential PAMP receptor ( s ) , we found that a human [G-protein coupled receptor] , MrgX2 , was specifically *activated* by . Positive_regulation GPR88 RGS2 19427970 2076900 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR97 RGS2 19427970 2076812 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPR98 RGS2 19427970 2076818 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Positive_regulation GPRC6A CABP4 16199532 1483147 Also , osteocalcin , a highly expressed in bone , dose-dependently *stimulated* [GPRC6A] activity in the presence of calcium but inhibited the calcium dependent activation of CASR . Positive_regulation GPS2 CCND1 21901538 2521952 We also found that when down regulation of p65 , the expression of and Bc1-2 decreased , and the expression of [SMRT] *increased* in vitro and vivo . Positive_regulation GPS2 INPP4B 21224358 2379448 Optimal induction of by an androgen receptor *required* the expression of the transcriptional coactivator [NCoR] . Positive_regulation GPS2 TLR7 21849441 2486217 Treatment with PPAR? and LXR ligands , but not GR ligands , prevented this *induced* clearance of [NCoR] from the LTR . Positive_regulation GPX1 IL1B 18291685 1924868 In parallel , markedly *enhanced* Mn SOD and [GPX] gene expressions , but decreased Cu/Zn SOD , EC SOD and CAT gene expressions . Positive_regulation GPX1 TNF 20112906 2206342 SOD and [GPx] expressions decreased ( p < 0.001 ) but that of *increased* significantly ( P < 0.001 ) in FT rats with respect to FC and NFT animals . Positive_regulation GPX2 IL1B 18291685 1924869 In parallel , markedly *enhanced* Mn SOD and [GPX] gene expressions , but decreased Cu/Zn SOD , EC SOD and CAT gene expressions . Positive_regulation GPX2 TNF 20112906 2206343 SOD and [GPx] expressions decreased ( p < 0.001 ) but that of *increased* significantly ( P < 0.001 ) in FT rats with respect to FC and NFT animals . Positive_regulation GPX2 TP63 16446369 1534227 Here , we found that [GPX2] , which encodes a glutathione peroxidase , is *up-regulated* by but not p53 . Positive_regulation GPX3 IL1B 18291685 1924870 In parallel , markedly *enhanced* Mn SOD and [GPX] gene expressions , but decreased Cu/Zn SOD , EC SOD and CAT gene expressions . Positive_regulation GPX3 TNF 20112906 2206344 SOD and [GPx] expressions decreased ( p < 0.001 ) but that of *increased* significantly ( P < 0.001 ) in FT rats with respect to FC and NFT animals . Positive_regulation GPX4 IL1B 18291685 1924871 In parallel , markedly *enhanced* Mn SOD and [GPX] gene expressions , but decreased Cu/Zn SOD , EC SOD and CAT gene expressions . Positive_regulation GPX4 TNF 17688422 1816673 These results indicate that C/EBPepsilon is a critical transcription factor in *induced* up-regulation of [PHGPx] expression . Positive_regulation GPX4 TNF 20112906 2206345 SOD and [GPx] expressions decreased ( p < 0.001 ) but that of *increased* significantly ( P < 0.001 ) in FT rats with respect to FC and NFT animals . Positive_regulation GPX5 IL1B 18291685 1924872 In parallel , markedly *enhanced* Mn SOD and [GPX] gene expressions , but decreased Cu/Zn SOD , EC SOD and CAT gene expressions . Positive_regulation GPX5 TNF 20112906 2206346 SOD and [GPx] expressions decreased ( p < 0.001 ) but that of *increased* significantly ( P < 0.001 ) in FT rats with respect to FC and NFT animals . Positive_regulation GPX6 IL1B 18291685 1924873 In parallel , markedly *enhanced* Mn SOD and [GPX] gene expressions , but decreased Cu/Zn SOD , EC SOD and CAT gene expressions . Positive_regulation GPX6 TNF 20112906 2206347 SOD and [GPx] expressions decreased ( p < 0.001 ) but that of *increased* significantly ( P < 0.001 ) in FT rats with respect to FC and NFT animals . Positive_regulation GPX7 IL1B 18291685 1924874 In parallel , markedly *enhanced* Mn SOD and [GPX] gene expressions , but decreased Cu/Zn SOD , EC SOD and CAT gene expressions . Positive_regulation GPX7 TNF 20112906 2206348 SOD and [GPx] expressions decreased ( p < 0.001 ) but that of *increased* significantly ( P < 0.001 ) in FT rats with respect to FC and NFT animals . Positive_regulation GPX8 IL1B 18291685 1924867 In parallel , markedly *enhanced* Mn SOD and [GPX] gene expressions , but decreased Cu/Zn SOD , EC SOD and CAT gene expressions . Positive_regulation GPX8 TNF 20112906 2206341 SOD and [GPx] expressions decreased ( p < 0.001 ) but that of *increased* significantly ( P < 0.001 ) in FT rats with respect to FC and NFT animals . Positive_regulation GRAP2 ANGPT1 12824293 1113655 Inhibitors of the PI-3 kinase pathway attenuated Ang-1 induced ERK1/2 phosphorylation at a level up-stream from Raf and MEK1/2 , but these inhibitors augmented *induced* [p38] phosphorylation . Positive_regulation GRAP2 CLU 23051594 2702794 FOXL2 directly stimulates the Clu gene promoter , and we show that PTTG triggers ataxia telangiectasia mutated [kinase/IGF-I/p38MAPK] DNA damage/chromosomal instability signaling , which in turn also *induces* expression . Positive_regulation GRAP2 CTGF 19011018 2047243 *increased* the phosphorylation of [p38] and ERK1/2 . Positive_regulation GRAP2 CTGF 20213804 2249223 *induced* phosphorylation of [p38] , ERK-1/2 , JNK , and Akt , but not Smad3 , in transgenic mouse fibroblasts compared with wild-type mouse fibroblasts . Positive_regulation GRAP2 DAPK1 24814693 2944970 DAPK3 siRNA or the inhibitor significantly *reduced* PDGF-BB induced activation of [p38] and heat-shock protein 27 (HSP27) as determined by Western blotting . Positive_regulation GRAP2 EPHB2 10629859 576455 In contrast with H2O2 induced activation of ERK , the activation of induced by phorbol ester PMA and the *activation* of JNK and [p38] induced by H2O2 were not affected by expression of GRK2-ct , indicating that the activation of ERK but not JNK and p38 is dependent on beta gamma subunit . Positive_regulation GRAP2 EPHB2 11350959 827761 Interestingly , Akt activation by UVB was attenuated by treatment with PD 98059 , a specific mitogen activated protein kinase/extracellular signal regulated protein kinase ( ) kinase 1 inhibitor , or SB 202190 , a specific [p38] kinase *inhibitor* . Positive_regulation GRAP2 EPHB2 12087068 959417 PTX mediated [p38] MAP kinase activation did not *involve* either p42/p44 , p60src , Rho family of GTPases , or phosphatidylinositol-3' kinase pathways . Positive_regulation GRAP2 EPHB2 12444545 1017456 Stimulation of the conditional mutant Delta MEKK3 : ER* in asynchronous hamster ( CCl39 ) and rat ( Rat-1 ) fibroblasts resulted in the strong activation of endogenous JNK and [p38] but only a weak *activation* of . Positive_regulation GRAP2 EPHB2 14998726 1216725 Furthermore , we found that PD98059 , an pathway inhibitor , and SB203580 , a [p38] MAPK *inhibitor* , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation GRAP2 EPHB2 15169879 1253541 This regulatory event is dependent upon the downstream activation of Ras and requires the activation of [p38] , JNK , and mitogen *activated* protein kinases . Positive_regulation GRAP2 EPHB2 15310753 1333338 bFGF induced sustained activation of and transient *activation* of [p38] ( MAPK ) , which was not associated with cell death . Positive_regulation GRAP2 EPHB2 15964118 1428219 In addition , the malvidin treatment significantly increased the [p38] kinase expression and inhibited the ERK activity , and the effects of malvidin on caspase-3 activation were *blocked* , respectively , by the and p38 inhibitors . Positive_regulation GRAP2 EPHB2 15969741 1440952 ERK1/2 but not JNK and [p38] were activated by GTS-21 , and the phosphorylation inhibitors PD98059 and U0126 *blocked* protection . Positive_regulation GRAP2 EPHB2 16033772 1473516 SB203580 , a specific *inhibitor* of [p38] and PD98059 , a specific inhibitor of , abolished sulforaphane induced MT protein expression , whereas SP600125 , a specific inhibitor of JNK , had no significant effect . Positive_regulation GRAP2 EPHB2 17606294 1842196 These data establish that TTP mediated TNF-alpha mRNA decay is inhibited by the combined activation of and p38 and not by [p38] *activation* alone . Positive_regulation GRAP2 EPHB2 18338254 1938053 Interestingly , inhibition of by U0126 completely *prevented* artepillin C-induced [p38] MAPK phosphorylation of PC12m3 cells . Positive_regulation GRAP2 EPHB2 18467504 1944667 Blockade of [p38] MAPK , but not MEK , *activation* of rescued EGF stimulated phosphorylation in the presence of TNF , consistent with the ability of TNFR1 to stimulate p38 phosphorylation . Positive_regulation GRAP2 EPHB2 19429670 2106916 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either inhibitor , [p38MAPK] *inhibitor* or NF-kappaB inhibitor . Positive_regulation GRAP2 EPHB2 19778233 2141052 The induction of TNF-alpha and TGF-beta1 by silica was suppressed by Src inhibitor ( PP1 ) , inhibitor ( PD98059 ) , but not by [p38] kinase *inhibitor* ( SB203580 ) . Positive_regulation GRAP2 EPHB2 22418436 2587978 Both [p38] MAPK promoted glucose regulated protein 78 (GRP78) expression and sustained high basal *activation* of PI3K/Akt and are involved in the cytoprotective function of p190Met ( NC ) . Positive_regulation GRAP2 EPHB2 23443666 2765652 IFN-? and GM-CSF production requires NF-?B and STAT3 activation as well as *dependent* mechanisms for IFN-? and [p38] signaling for GM-CSF . Positive_regulation GRAP2 EPHB2 23877364 2854509 We subsequently used JNK inhibitor , [P38] *inhibitor* , and inhibitor to block the downstream MAPK pathways of TLR4 in macrophages , and found that LPS induced CSE expression and H2S synthesizing activity were inhibited by pretreatment with the p38 inhibitor . Positive_regulation GRAP2 EPHB2 9366464 463318 Transient experiments in COS cells revealed potent stimulation of by mu and delta receptor activation , weak stimulation of stress activated protein kinase by all receptor types , and no *activation* of [p38] . Positive_regulation GRAP2 F2R 10405323 629334 Thrombin , a agonist peptide , a thromboxane A ( 2 ) analogue , collagen , crosslinking the glycoprotein VI , ADP , and epinephrine , but not phorbol 12 , 13-dibutyrate *activated* [p38] . Positive_regulation GRAP2 F2R 11841573 912182 Activation of the microglial *induces* a rapid cytosolic free [ Ca2+ ] i increase and transient activation of both [p38] and p44/42 mitogen activated protein kinases . Positive_regulation GRAP2 FAS 10200443 561091 Here , we demonstrate that receptor triggered activation of the acidic sphingomyelinase , consumption of sphingomyelin , release of ceramide , and subsequent activation of JNK and [p38-K] are *regulated* by caspases . Positive_regulation GRAP2 FAS 12132586 966897 The mediated [p38] *activation* is suppressed in core expressing HepG2 cell lines , as well as in the hepatocytes of transgenic mice . Positive_regulation GRAP2 FAS 12556535 1071633 Apoptosis signal regulating kinase 1 ( ASK1 ) is a MAP kinase kinase kinase ( MAPKKK ) that is required for c-Jun N-terminal kinase (JNK) and [p38] activation in *response* to and tumor necrosis factor (TNF) receptor stimulation , and for oxidative stress- and TNFalpha induced apoptosis . Positive_regulation GRAP2 FAS 16024776 1435372 In contrast , mediated *activation* of JNK , [p38] , and p42/44 occurred essentially independent from IFN-gamma sensitization , indicating that the apoptosis- and NF-kappaB related FasL-IFN-gamma cross talk was not due to a simple global enhancement of Fas signaling . Positive_regulation GRAP2 FAS 20658220 2316953 To distinguish between the activation signalling and the death inducing pathway downstream of Fas , we generated a novel T cell line expressing a chimeric hCD8-FasC protein and found that stimulation with the anti-CD8 antibodies *induced* tyrosine phosphorylation of TCR-proximal proteins , activation of Raf-1/ERK , [p38] and JNK , and increased expression of CD69 , , and Fas ligand . Positive_regulation GRAP2 FAS 21454681 2422400 Analyzing non-apoptotic signaling pathways , we found that TRAIL and *activate* JNK and [p38] within 15 min . cFLIP variants and different caspase inhibitors blocked late death ligand induced JNK or p38 MAPK activation suggesting that these responses are secondary to cell death . Positive_regulation GRAP2 FAS 8972182 408504 In this study *activated* the stress-responsive mitogen activated protein kinases , [p38] and JNK , within 2 h in Jurkat T lymphocytes but not the mitogen-responsive kinase ERK1 or pp70S6k . Positive_regulation GRAP2 FZD4 23660333 2805393 Here we reported that could obviously induce S phase cell cycle arrest , suppress cell growth , *increase* the activity of phosphorylated [p38] ( p-p38 ) , and decrease the activity of phosphorylated JNK ( p-JNK ) in HepG2 cells . Positive_regulation GRAP2 IL1B 10201954 605709 *activated* [p38alpha] and p38beta in endothelial cells . Positive_regulation GRAP2 IL1B 10593906 572878 Overexpression of the kinase-dead mutant form of MKK3 or MKK6 demonstrated that either of these two mutant kinase inhibited *induced* [p38] ( MAPK ) ( but not JNK/SAPK ) phosphorylation and iNOS expression . Positive_regulation GRAP2 IL1B 10601882 574641 iNOS induction involves activation by phosphorylation of the MAP kinase [p38] and can be *induced* in cultured astrocytes by or H2O2 . Positive_regulation GRAP2 IL1B 10807411 692192 To investigate whether *activates* MAP kinases [ extracellular signal regulated kinases ( ERKs ) , c-Jun NH2-terminal kinases (JNKs) and [p38 MAP kinase (p38 MAPK)] ] and nuclear factor (NF)-kappaB . Positive_regulation GRAP2 IL1B 10863542 705484 In rat primary astrocytes [p38] *activation* by the pro-inflammatory cytokine , as well as by H2O2 , was significantly suppressed by PBN . Positive_regulation GRAP2 IL1B 10995825 733626 Intracerebroventricular injection of IL-1beta increased reactive oxygen species production in hippocampal tissue , whereas and H ( 2 ) O ( 2 ) *increased* activities of both JNK and [p38] in vitro . Positive_regulation GRAP2 IL1B 11032891 740435 *induces* [p38] MAPK phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation GRAP2 IL1B 11141234 780198 In the cytokine stimulation studies , *stimulated* [p38] activation in a dose dependent manner , while JNK was relatively unaffected . Positive_regulation GRAP2 IL1B 11259436 818714 Furthermore , the ability of IL-1beta to activate NF-kappaB is known to involve Akt , and we show here that *induces* [p38] activity in manner dependent on Akt and IkappaB kinase activation . Positive_regulation GRAP2 IL1B 11275558 797841 Immunoblot analysis involving anti-IkappaB kinase (IKK)-alpha and anti-phosphoserine antibodies revealed that N2733 inhibited IL-1beta induced IKK-alpha phosphorylation , whereas N2733 had no inhibitory effect on *stimulated* p42/p44 MAP kinase or [p38] MAP kinase activity . Positive_regulation GRAP2 IL1B 11399523 824255 Glucose potentiates *induced* [p38] mitogen activated protein kinase activity in rat pancreatic islets of Langerhans . Positive_regulation GRAP2 IL1B 11399523 824268 *activates* the mitogen activated protein kinases (MAPK) extracellular signal regulated kinase 1 and 2 ( ERK1/2 ) , [p38] and c-jun NH2-terminal kinase ( JNK ) in rat islets and beta-cells . Positive_regulation GRAP2 IL1B 11399523 824271 The aim of this study was to investigate whether glucose potentiated *induced* [p38] and ERK1/2 activity in rat islets . Positive_regulation GRAP2 IL1B 11455208 837914 TNF-alpha and *activated* p44/42 and [p38] mitogen activated protein kinases ( MAPKs ) in HUVECs ; Positive_regulation GRAP2 IL1B 11605009 871543 Pretreatment with SB203085 inhibited *induced* [p38] and AKT phosphorylation . Positive_regulation GRAP2 IL1B 11775830 766448 transiently increased protein tyrosine phosphorylation , and *activated* the MAPKs cascades ( mainly ERK2 , JNK2 and [P38] ) in RA FLS . Positive_regulation GRAP2 IL1B 11853544 913366 Interestingly , *induced* [p38] MAPK activity was greatly enhanced in ( alg+ ) compared with ( alg- ) cells . Positive_regulation GRAP2 IL1B 11854442 913954 Furthermore , Ro 31-8220 inhibited *induced* [p38] phosphorylation but not ERK phosphorylation . Positive_regulation GRAP2 IL1B 12391274 1007551 These results indicate that in human pulmonary epithelial cells , *activates* ERK or [p38] to induce COX-2 production , which in turn induces MUC2 and MUC5AC production . Positive_regulation GRAP2 IL1B 12637577 1099335 This strategy established the *requirement* for [p38] activity for the lipopolysaccharide stimulated production of IL-10 , , and IL-6 by the monocytic cell WEHI 274 and the production of IL-6 and TNFalpha stimulated by ligation of the Fc-gamma receptor of the mast cell MC/9 . Positive_regulation GRAP2 IL1B 12727980 1086552 [P38] MAPK phosphorylation was *increased* by in nondecidualized ESC , whereas the IL-1 beta induced increase was suppressed in the decidualized cells . Positive_regulation GRAP2 IL1B 12727980 1086579 In contrast , treatment with H89 , a protein kinase A inhibitor , reversed a reduction in *induced* [p38] MAPK phosphorylation in the decidualized cells . Positive_regulation GRAP2 IL1B 12799018 1100963 induced release of IL-6 and *activated* NFkappaB , [p38] , JNK and ERK1/2 in mixed glial cultures , which was completely abolished in the presence of IL-1 receptor antagonist (IL-1ra) . Positive_regulation GRAP2 IL1B 15048855 1225175 Therefore , , which contributes to stroke induced brain injury and *activates* [p38/SAPK2] , and hyperosmolarity induced by sorbitol , a potent stimulus of p38/SAPK2 in non-neuronal cells , were used to investigate a possible involvement of p38/SAPK2 in GJC modulation in mouse cultured astrocytes . Positive_regulation GRAP2 IL1B 15111866 1241219 We further addressed the role of the mitogen activated protein kinase [p38] , which is *activated* by PDGF-BB and by . Positive_regulation GRAP2 IL1B 15145599 1247714 Lipopolysaccharide (LPS) has a negative impact on long-term potentiation ( LTP ) in the rat hippocampus , which has been correlated with increased concentration of and *activation* of [p38] and c-Jun N-terminal kinase (JNK) . Positive_regulation GRAP2 IL1B 15240007 1269934 EGF stimulated comparable or lower Erk1/2 , p38 and Akt phosphorylation while *induced* [p38] phosphorylation in the fibroblast cell lines . Positive_regulation GRAP2 IL1B 15341531 1291755 In accordance with these findings , *stimulated* phosphorylation of p42/p44 MAPK , [p38] , and c-Jun N-terminal kinase (JNK) , which was attenuated by U0126 , SB202190 , or SP600125 , respectively . Positive_regulation GRAP2 IL1B 15477222 1342481 SP600125 ( 20 microM ) had no effect on *induced* ERK and [p38] phosphorylation . Positive_regulation GRAP2 IL1B 15749024 1379447 Recombinant mouse *induced* strong activation of ERK1/2 , [p38] , JNK and NFkappa B , and significant release of IL-6 and PGE2 , which was blocked by IL-1ra . Positive_regulation GRAP2 IL1B 15778394 1385088 rapidly *induced* [p38] phosphorylation in cells transfected with empty vector ( pcDNA3.1 ) , but was inhibited by 25 % in cells expressing DN MKK3 or DN MKK6 . Positive_regulation GRAP2 IL1B 15831571 1417980 Activation of [p38] and ERK in *response* to was also dependent on L-type Ca ( 2+ ) influx . Positive_regulation GRAP2 IL1B 16033422 1436160 Intrathecal *leads* to a time dependent up-regulation of phosphorylated [p38] ( p-p38 ) MAPK protein expression in the spinal cord 30-240 min following IL-1beta injection ( i.t. ) . Positive_regulation GRAP2 IL1B 16033422 1436174 However , pretreatment with a p38 MAPK inhibitor significantly reduced the *induced* [p-p38] MAPK expression by 38-49 % , and nearly completely blocked the subsequent iNOS expression ( reduction by 86.6 % ) , NO production , and thermal hyperalgesia . Positive_regulation GRAP2 IL1B 16132952 1461182 Likewise , *induced* JNK and [p38] activities were lower in iNOS ( -/- ) mouse islets than in wild-type islets . Positive_regulation GRAP2 IL1B 16140882 1450800 *induced* phosphorylation of [p38-MAPK] , but not that of c-Jun-N-terminal kinase or extracellular regulated kinase , was most susceptible to inhibition by low doses of PFE , and the addition of PFE blocked the activity of p38-MAPK in a kinase activity assay . Positive_regulation GRAP2 IL1B 16258191 1477773 Proinflammatory cytokine *caused* a transient activation of Erk1/2 , [p38] , and JNK in immortalized human T/C28a2 chondrocytes and that was followed by enhanced COX-2 expression and PGE2 production . Positive_regulation GRAP2 IL1B 16552807 1538044 Western blot was performed to measure *induced* JNK and [p38] activities in rat HSC . Positive_regulation GRAP2 IL1B 16552807 1538045 *activated* JNK and [p38] in a time dependent manner . Positive_regulation GRAP2 IL1B 16881054 1613798 Both and MEKK1 *stimulated* [p38] and JNK MAPKs , as well as the NF-kappaB pathway , to induce iNOS in C6 cells . Positive_regulation GRAP2 IL1B 17067555 1674959 Pretreatment of cells with tangeretin inhibited *induced* [p38] MAPK , JNK , and AKT phosphorylation and the downstream activation of NF-kappaB . Positive_regulation GRAP2 IL1B 17208222 1695808 Thalidomide also suppressed *induced* [p38] mitogen activated protein kinase (MAPK) activation , while a p38 MAPK inhibitor destabilized COX-2 mRNA and the cytoplasmic shuttling of HuR induced by IL-1beta . Positive_regulation GRAP2 IL1B 17337443 1726635 IRAK-4 KD cells are severely impaired in NFkappaB , JNK , and [p38] activation in *response* to or TLR7 ligand . Positive_regulation GRAP2 IL1B 17391766 1727754 Furthermore , lipopolysaccharide , CpG oligonucleotides and recombinant trout *induced* endogenous phosphorylation of [p38] in salmon head kidney macrophages in a dose dependent manner . Positive_regulation GRAP2 IL1B 17694686 1782097 IL-1beta induced NO levels and thermal hyperalgesia in rats , likely via either inhibiting the mediated [p38] MAPK *activation* and subsequent iNOS induction , or direct attenuation of the central iNOS activity , which therefore reduces the central sensitization of inflammatory pain . Positive_regulation GRAP2 IL1B 18467203 1921442 Phospho-ELISA and Western blots showed that *activated* JNK and [p38] , but not ERK 1/2 MAP kinase . Positive_regulation GRAP2 IL1B 18510099 1840589 IRAK-4 KD cells were severely impaired in NF-kappaB , JNK , and [p38] activation in *response* to or TLR7 ligand . Positive_regulation GRAP2 IL1B 18583302 1953149 TNF-alpha and significantly *increase* [p38] expression . Positive_regulation GRAP2 IL1B 18658272 1967186 It is concluded that : 1 ) flagellin and *activated* [p38] , NF-kappaB , IL-8 , and CFTR dependent anion secretion without altering tight junction permeability ; Positive_regulation GRAP2 IL1B 18667841 1948047 Furthermore , *induced* [p38] mitogen activated protein kinase (MAPK) activation and upregulation of VEGF-C mRNA and protein in LLC cells was also suppressed by artemisinin or by the p38 MAPK inhibitor SB-203580 , suggesting that p38 MAPK could serve as a mediator of proinflammatory cytokine induced VEGF-C expression . Positive_regulation GRAP2 IL1B 19056796 2017700 Moreover , cordycepin significantly inhibited *induced* [p38/JNK] and AP-1 activation , but not extracellular signal regulated kinase ( ERK ) and NF-kappaB activation . Positive_regulation GRAP2 IL1B 19136710 2060847 Brief stimulation of CECs with *activated* PI 3-kinase and [p38] in a biphasic fashion . Positive_regulation GRAP2 IL1B 19229069 2054632 Additionally , IL-8 reduced [p38] activation and NF-kappaB activity *induced* by alone . Positive_regulation GRAP2 IL1B 19248106 2045040 *induced* activation of [p38] and JNK was slightly decreased by CS , whereas that of ERK-1/2 and Akt was enhanced . Positive_regulation GRAP2 IL1B 19765281 2163518 Treatment with PIP-18 blocked *induced* [p38] MAPK phosphorylation and resulted in attenuation of sPLA2-IIA and MMP mRNA transcription in RA SF cells . Positive_regulation GRAP2 IL1B 20633667 2310414 Stimulation of chondrocytes with either or Fn-f *led* to enhanced phosphorylation of [p38alpha] and p38gamma , with little phosphorylation of p38beta or p38delta isoforms . Positive_regulation GRAP2 IL1B 9575890 502720 Our data also indicate that both insulin and IGF-I enhance *induced* [p38] mitogen activated protein kinase (MAPK) phosphorylation and SAPK activation . Positive_regulation GRAP2 IL1B 9786861 540955 Overexpression of the kinase-dead form of MKK3 or MKK6 demonstrated that either of these two mutant kinases inhibited *induced* [p38] MAPK phosphorylation and Cox-2 expression but not JNK/SAPK phosphorylation and activation . Positive_regulation GRAP2 MAP2K6 10527909 654342 SEK1 phosphorylates and activates both p38 and c-Jun NH ( 2 ) -terminal kinase ( JNK ) , whereas MKK3 and selectively phosphorylate and *activate* [p38] . Positive_regulation GRAP2 MAP2K6 10570156 568117 c-Abl induced [p38] activation was primarily *mediated* by ( MKK)6 . Positive_regulation GRAP2 MAP2K6 10816593 714741 alpha B-crystallin gene induction and phosphorylation by *activated* [p38] . Positive_regulation GRAP2 MAP2K6 11010976 752630 We also found that the preferential *activation* of [p38alpha] by correlated with more efficient binding of MKK6 to p38alpha than to p38gamma . Positive_regulation GRAP2 MAP2K6 11971971 933743 Constitutive *activation* of [p38] by active MKK3 or induces senescence . Positive_regulation GRAP2 MAP2K6 12181443 977733 Among 12 cell lines that we tested , 11 respond to LPA and S1P and all of the responsive cell lines *require* [p38] but only nine of them require . Positive_regulation GRAP2 MAP2K6 12450322 1018612 ANG II significantly increased aldosterone release , and this effect was inhibited by the LO inhibitor baicalein , as well as a specific [p38] MAPK *inhibitor* , SB202190 , but not by PD098059 , a specific inhibitor of the ERK activator . Positive_regulation GRAP2 MAP2K6 14708598 1181085 *Activation* of [p38] alone by adenovirally delivered constitutively active MAPK kinase 3b (MKK3b) and also enhanced MMP-19 production , and the most potent induction of MMP-19 expression was noted when ERK1/2 was activated in combination with p38 . Positive_regulation GRAP2 MAP2K6 15104236 1240165 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a [p38] mitogen activated protein kinase (MAPK) *inhibitor* , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( ) inhibitor , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation GRAP2 MAP2K6 15365248 1294442 Treatment of keratinocytes with PD98059 , inhibitor , and SB20358 , [p38] MAPK *inhibitor* , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation GRAP2 MAP2K6 15492008 1359462 The objectives of the current study were to examine the effects of mediated [p38] *activation* in the heart in vivo . Positive_regulation GRAP2 MAP2K6 15867183 1404210 In cultured cardiac myocytes , specific *activation* of stress activated mitogen activated protein kinase , [p38] , by upstream activator led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation GRAP2 MAP2K6 15879307 1411353 Conversely , constitutively active *induced* [p38] MAPK activation that recapitulated the effects of polyphenols by inducing ERalpha phosphorylation and downstream activation of Akt , and eNOS . Positive_regulation GRAP2 MAP2K6 16157033 1455634 SB203580 , a [P38MAPK] *inhibitor* , and U0126 , a inhibitor , both completely blocked ADM mediated responses in MsC . Positive_regulation GRAP2 MAP2K6 16342939 1491917 We now demonstrate that selectivity pocket compounds prevent dependent *activation* of [p38alpha] in addition to inhibiting catalysis by activated p38alpha . Positive_regulation GRAP2 MAP2K6 16352664 1504372 The phosphorylation of [p38alpha] induced by NP60 *requires* upstream activity of p38alpha MAP kinase , or MKK4 . Positive_regulation GRAP2 MAP2K6 18754769 1968408 ( MKK) 3 and 6 are the main [p38] mitogen activated protein kinase *activators* in mammals . Positive_regulation GRAP2 MAP2K6 19209848 2179617 On the other hand , [p38alpha] ( WT ) and intrinsically active mutants carrying the Y182F mutation are *activated* by in vitro and in vivo , although to low levels , mainly due to reduced affinity for the substrate . Positive_regulation GRAP2 MAP2K6 20127863 2248426 Furthermore , expression *activated* [p38] and C/EBPalpha , increasing IGFBP-5 promoter activity and expression . Positive_regulation GRAP2 MAP2K6 22053010 2562621 *Enhancement* of [p38] activation by constitutively active ( MKK6E ) increased ERCC1 protein levels . Positive_regulation GRAP2 MAP2K6 22413812 2600524 The H2O2 augmented IFN? induced IL-32 mRNA expression was suppressed by a JNK inhibitor , but not by inhibitor , [p38] *inhibitor* , and JAK inhibitor I. Significant binding of c-Jun and CREB to the IL-32 promoter was observed in the IFN? + H2O2 stimulated HBE cells . Positive_regulation GRAP2 MAP2K6 22418436 2587987 Both [p38] MAPK promoted glucose regulated protein 78 (GRP78) expression and sustained high basal *activation* of PI3K/Akt and are involved in the cytoprotective function of p190Met ( NC ) . Positive_regulation GRAP2 MAP2K6 8663524 368608 A comparison of events associated with the activation of p38beta and p38 revealed differences , most notably in the preferred *activation* of [p38beta] by , whereas p38 was activated nearly equally by MKK3 , MKK4 , and MKK6 . Positive_regulation GRAP2 MAP2K6 8861944 388570 However , under our assay conditions , was the major *activator* of [RK/p38] detected in extracts prepared from stress- or interleukin-1 stimulated epithelial ( KB ) cells , from bacterial lipopolysaccharide and tumour necrosis factor alpha stimulated THP1 monocytes or from rabbit skeletal muscle . Positive_regulation GRAP2 MAP2K6 9242520 446068 [p38] can generally be *activated* by the upstream kinase MKK3 or . Positive_regulation GRAP2 MAP2K6 9295308 453160 We also observed that [p38delta] was strongly *activated* by MKK3 and , while p38alpha was preferentially activated by MKK6 . Positive_regulation GRAP2 MAP2K6 9362518 462832 Here , we have shown that MKK7 , but not SEK1/ MKK4 , is activated by Fas as an activator for JNK/ SAPK and that is a major *activator* for [p38] in Fas signaling . Positive_regulation GRAP2 MAP2K6 9374491 464878 [p38delta] can be *activated* by MKK3 and , known activators of the other isoforms . Positive_regulation GRAP2 PGC 23443926 2771445 ß-Adrenergic stimulation does not activate [p38] MAP kinase or *induce* in skeletal muscle . Positive_regulation GRAP2 PLAT 21037505 2499490 Red blood blocked c-Jun-N-terminal kinase but *potentiated* [p38] mitogen activated protein kinase upregulation after photothrombotic injury . Positive_regulation GRAP2 PLAU 10766865 684600 surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive [p38alpha] mitogen activated protein kinase activity . Positive_regulation GRAP2 S100A7 18194266 1918939 Furthermore , *induces* phosphorylation of mitogen activated protein kinase [p38] and extracellular signal regulated kinase ( ERK ) , but not c-Jun N-terminal kinase (JNK) , both of which are required for the production of cytokines and chemokines as evidenced by the inhibitory effects of p38 and ERK inhibitors on psoriasin mediated neutrophil activation . Positive_regulation GRAP2 S100B 22082983 2540800 In RAGE-A10 , *activated* JNK , MEK-1 and [p38] . Positive_regulation GRAP2 SELL 18332130 1898160 In addition , ligation of and L-selectin-v1 , but not L-selectin-v2 , *induced* [p38] mitogen activated protein kinase phosphorylation . Positive_regulation GRAP2 SLC38A3 11208554 787171 *induced* [p38] kinase activity at doses and with kinetics similar to those observed for Akt induction . Positive_regulation GRAP2 SPHK1 21233411 2409050 These results define a pathway leading to NOX2 activation , in which [p38] MAPK mediated S100A8/A9 translocation is *regulated* by Ca ( 2+ ) store depletion dependent activation . Positive_regulation GRAP2 TLR7 15998638 1447144 Here , we show that A52R does not inhibit *induced* [p38] or c-Jun amino N-terminal kinase (JNK) mitogen activating protein ( MAP ) kinase activation . Positive_regulation GRAP2 TNF 10201904 605667 *induced* tyrosine phosphorylation and enzymatic activation of ERK2 , SAPK/JNK , and [p38mapk] , whereas IL-10 did not induce these events . Positive_regulation GRAP2 TNF 10329406 613178 We examined the regulatory role of a reduction/oxidation ( redox ) control protein , thioredoxin (TRX) , in *induced* [p38] MAP kinase activation and p38 MAP kinase mediated cytokine expression utilizing TRX transfected murine L929 cells ( TRX14 ) . Positive_regulation GRAP2 TNF 10329406 613180 The results showed that induced [p38] MAP kinase *activation* and interleukin-6 (IL-6) production by TRX 14 were less than those by the parental L cells and the control transfected L cells ( Neo-1 ) . Positive_regulation GRAP2 TNF 10504489 648977 Pretreatment with SB203580 ( 10 microM ) had no effect on basal or TNF-alpha stimulated phosphorylation of p38 MAPK but completely abolished *stimulated* [p38] MAPK activity . Positive_regulation GRAP2 TNF 10604552 575043 Abrogation of p38 MAP kinase activity by SB 203580 repressed *induced* [p38] MAP kinase activity and RANTES production . Positive_regulation GRAP2 TNF 10783388 707844 dependent [p38] MAPK *activation* was detected in both Mo7e and Hut-78 cells and was blocked by the p38 MAPK inhibitor , SB203580 . Positive_regulation GRAP2 TNF 10783388 707897 SB203580 did not affect TNF-alpha signaled nuclear translocation and DNA binding activity of NF-kappaB , and inhibition of NF-kappaB function did not affect induced [p38] MAPK *activation* , indicating that these events are not dependent on each other . Positive_regulation GRAP2 TNF 10843427 700079 Regulation by intracellular glutathione of *induced* [p38] MAP kinase activation and RANTES production by human pulmonary vascular endothelial cells . Positive_regulation GRAP2 TNF 10843427 700080 However , a regulatory role of intracellular glutathione ( GSH ) in *induced* [p38] MAP kinase activation and p38 MAP kinase mediated RANTES production has not been determined . Positive_regulation GRAP2 TNF 10843427 700081 Human pulmonary vascular endothelial cells were exposed to N-acetylcysteine (NAC) or buthionine sulfoximine ( BSO ) , and then *induced* [p38] MAP kinase activation and p38 MAP kinase mediated RANTES production were determined . Positive_regulation GRAP2 TNF 10843427 700082 The results showed that 1 ) NAC attenuated TNF-alpha induced p38MAP kinase activation and RANTES production 2 ) SB 203580 as the specific inhibitor of p38 MAP kinase activity attenuated TNF-alpha induced RANTES production 3 ) BSO facilitated *induced* [p38] MAP kinase activation and RANTES production 4 ) SB 203580 attenuated BSO mediated facilitation of TNF-alpha induced RANTES production . Positive_regulation GRAP2 TNF 11108246 756723 *activates* extracellular regulated kinase-1/2 ( ERK1/2 ) and [p38MAPK] . Positive_regulation GRAP2 TNF 11156586 780609 N-acetylcysteine attenuates *induced* [p38] MAP kinase activation and p38 MAP kinase mediated IL-8 production by human pulmonary vascular endothelial cells . Positive_regulation GRAP2 TNF 11156586 780623 However , the effect of N-acetylcysteine (NAC) , which acts as a precursor of glutathione ( GSH ) synthesis , on *induced* activation of p38 MAP kinase pathway and [p38] MAP kinase mediated IL-8 production by human pulmonary vascular endothelial cells has not been determined . Positive_regulation GRAP2 TNF 11165942 782837 In this study , *stimulated* NF-kappaB binding affinity as well as [p38] MAP kinase activation , leading to the release of IL-6 . Positive_regulation GRAP2 TNF 11167962 783074 However , a role of cellular redox regulated by intracellular glutathione ( GSH ) in *induced* [p38] MAP kinase activation and p38 MAP kinase mediated RANTES production by human BECs has not been determined . Positive_regulation GRAP2 TNF 11167962 783075 *induced* [p38] MAP kinase activation and p38 MAP kinase mediated RANTES production by human BECs were then examined in order to clarify these issues . Positive_regulation GRAP2 TNF 11167962 783078 BSO facilitated *induced* [p38] MAP kinase activation and RANTES production ; Positive_regulation GRAP2 TNF 11319753 806833 SB 203580 , a selective inhibitor of p38 MAPK , inhibited IL-1 and *induced* [p38] MAPK activity and IL-6 production ( IC ( 50 ) s 0.3 -- 0.5 microM ) in osteoblasts and chondrocytes . Positive_regulation GRAP2 TNF 11353829 815156 or IL-1 alone *activated* ERK1/2 , [p38] , and JNK maximally at 15 min in HUVEC . Positive_regulation GRAP2 TNF 11455208 837913 and IL-1beta *activated* p44/42 and [p38] mitogen activated protein kinases ( MAPKs ) in HUVECs ; Positive_regulation GRAP2 TNF 11820362 908748 Transfection of IL-6 full-length and 5-deletion gene promoter reporter constructs indicated that [p38] MAPK *activation* by enhanced IL-6 gene expression , and that the p38 MAPK-responsive region resided in the proximal 260-bp segment . Positive_regulation GRAP2 TNF 11820362 908784 In conclusion , although [p38] MAPK *activation* by stimulates IL-6 secretion by MG-63 cells , it has opposing effects on c/EBPbeta and NFkappaB activity . Positive_regulation GRAP2 TNF 11988488 936321 ANP significantly reduced the *induced* activation of [p38] and attenuated the phosphorylation of HSP27 , a central target downstream of p38 . Positive_regulation GRAP2 TNF 12095140 960560 significantly increased permeability and *induced* [p38] and ERK MAPK activation compared with controls ( P < 0.05 ) . Positive_regulation GRAP2 TNF 12511413 1079022 The treatment of RAW264 cells with TSA and NaB inhibited *induced* nuclear translocation of NF-kappa B and sRANKL induced activation of [p38] mitogen activated protein kinase (MAPK) signals . Positive_regulation GRAP2 TNF 12554784 1057038 , which *activates* three different MAPKs [ERK , [p38] , and jun amino terminal kinase ( JNK ) ] , also induces insulin resistance . Positive_regulation GRAP2 TNF 12637577 1099265 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and *requires* [p38] MAPK activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation GRAP2 TNF 12637577 1099333 This strategy established the *requirement* for [p38] activity for the lipopolysaccharide stimulated production of IL-10 , IL-1beta , and IL-6 by the monocytic cell WEHI 274 and the production of IL-6 and stimulated by ligation of the Fc-gamma receptor of the mast cell MC/9 . Positive_regulation GRAP2 TNF 12684435 1078024 In DRG , [p38] activation is *blocked* by systemic inhibition . Positive_regulation GRAP2 TNF 12686737 1078171 *activated* ERK1/2 , JNK , and [p38] maximally at 15 min in HUVEC . Positive_regulation GRAP2 TNF 12776182 1095414 We found that *induced* activation of ERK , [p38] and JNK is decreased in Rip ( -/- ) cells . Positive_regulation GRAP2 TNF 12829618 1113800 However , *induced* [p38-MAPK] phosphorylation was markedly diminished in mkk3-/- vs mkk3+/+ hearts ( percent basal , 127+/-23 versus 540+/-267 , respectively , P=0.04 ) , suggesting an MKK independent activation mechanism by ischemia . Positive_regulation GRAP2 TNF 12867430 1141962 Subsequently , mediated [p38] MAPK *activation* induced sialidase activity and CD44-HA binding . Positive_regulation GRAP2 TNF 12893778 1121024 We show that MKK3 and MKK6are essential for *stimulated* [p38] MAPK activation . Positive_regulation GRAP2 TNF 14585994 1159349 In transfection studies , RIP1 and TRAF2 stimulate p38 MAP kinase activation , and dominant negative forms of RIP1 and TRAF2 inhibit induced [p38] MAP kinase *activation* . Positive_regulation GRAP2 TNF 14585994 1159352 We found induced [p38] MAP kinase *activation* and interleukin-6 (IL-6) production impaired in rip1 ( -/- ) murine embryonic fibroblasts (MEF) but unaffected in traf2 ( -/- ) MEF . Positive_regulation GRAP2 TNF 14636891 1188118 CPPD crystal associated repression of induced activation of neutrophil apoptosis as determined by DNA fragmentation correlated with the CPPD crystal *mediated* inhibition of [p38] kinase activity , probably through crystal inhibition of caspase 3 . Positive_regulation GRAP2 TNF 14654378 1176823 These findings suggest that the pre-ischemic *activation* of [p38-MAPK] by does not contribute to cardioprotection afforded by this agent . Positive_regulation GRAP2 TNF 14713952 1202641 Here , we demonstrate that TRAF2 ubiquitination is required for induced *activation* of JNK but not of [p38] or NF-kappaB . Positive_regulation GRAP2 TNF 15102856 1258308 We further report that incubation of neutrophils with *results* in the [p38] MAPK dependent phosphorylation of a subpopulation of p47(phox) and p67(phox) molecules , whereas PAF priming results in phosphorylation only of p67(phox) . Positive_regulation GRAP2 TNF 15162440 1253008 In contrast , AgC10 did not affect [p38] activation *induced* by . Positive_regulation GRAP2 TNF 15175328 1273488 *induced* Ikk and [p38] MAP kinase activation is normal , and the Rip1D138N cells are resistant to TNF-alpha induced cell death , indicating that the kinase activity of Rip1 is not required to mediate its antiapoptotic functions . Positive_regulation GRAP2 TNF 15265709 1275488 Taken together , our results suggest that *induced* [p38] MAPK mediated phosphorylation of Bcl-x ( L ) in endothelial cells leads to degradation of Bcl-x ( L ) in proteasomes and subsequent induction of apoptosis . Positive_regulation GRAP2 TNF 15489375 1359456 also , *induced* [p38] kinase activation was blocked by inhibition of PKCdelta , suggesting that p38 kinase is apparently situated downstream of PKCdelta in the TNF-alpha signaling pathway to VCAM-1 expression . Positive_regulation GRAP2 TNF 15492857 1321720 The *induced* activation of c-Jun N-terminal kinase (JNK) , [p38] , and NF-kappaB was not affected by Delta-1 stimulation . Positive_regulation GRAP2 TNF 15550066 1338540 IL-1beta , and H ( 2 ) O ( 2 ) *stimulated* the phosphorylation of ERK , [p38] and JNK , while the total amounts of proteins of the respective MAPKs were virtually the same compared with those in the unstimulated controls . Positive_regulation GRAP2 TNF 15650392 1364024 N-Acetyl-L-cysteine ( 20 mM ) inhibited both H2O2- and *induced* [p38] phosphorylation ( 14 +/- 7 and 37 +/- 4 % of control , respectively ) . Positive_regulation GRAP2 TNF 15650392 1364025 The mitochondrial complex I and III inhibitors , rotenone and antimycin A , and allopurinol partially inhibited H2O2- but not *induced* [p38] activation . Positive_regulation GRAP2 TNF 15775695 1397290 We hypothesize that bile-pancreatic juice exclusion activates [p38] ( MAPK ) and *induces* production in ligation induced acute pancreatitis . Positive_regulation GRAP2 TNF 15857937 1432695 Using the specific p38 inhibitor ( SB203580 ) , we confirmed that the increase in alpha production by LPS stimulated burn macrophages *requires* [p38] activation . Positive_regulation GRAP2 TNF 16117790 1449205 RXM partially suppressed [p38] phosphorylation and NFkappaB-driven luciferase activity *induced* by and IFNgamma . Positive_regulation GRAP2 TNF 16207331 1464341 These data indicate that preferentially *activates* [p38MAPKalpha] and ERK in synovial membrane exposed to TNF . Positive_regulation GRAP2 TNF 16287858 1481151 As [p38] is *activated* by , the p38beta-/- mice were crossed onto a TNFDeltaARE mouse line . Positive_regulation GRAP2 TNF 16314440 1486994 treatment *induced* [p38] mitogen activated protein kinase (MAPK) phosphorylation in NPCs , and SB202190 , an inhibitor of p38 MAPK , blocked TNF-alpha induced chemokine production . Positive_regulation GRAP2 TNF 16385569 1533420 Moreover , knockdown of endogenous TAK1 using small interfering RNA ( siRNA ) suppressed the *induced* [JNK/p38] activation , migration and pulmonary metastasis . Positive_regulation GRAP2 TNF 16394012 1506055 This study tested the hypothesis that ERM proteins are phosphorylated on this critical threonine residue through *induced* activation of PKC and [p38] and modulate permeability increases in pulmonary microvascular ECs . Positive_regulation GRAP2 TNF 16567640 1542315 These studies showed that *increased* phosphorylation of [p38] in WT cultured synoviocytes but that p38 activation , IL-1beta , and IL-6 expression were markedly lower in MKK3 ( -/- ) synoviocytes . Positive_regulation GRAP2 TNF 16616699 1562733 We observed that EPA or DHA alone significantly reduced the *induced* activation of [p38] and JNK kinases at a concentration of 20 microM , but EPA is a more potent inhibitor than DHA . Positive_regulation GRAP2 TNF 16616699 1562734 Meanwhile , both EPA and DHA significantly attenuated the *induced* expression of [p38] and ERK1/2 mRNA , and DHA but not EPA also reduced the TNF-alpha induced JNK mRNA expression . Positive_regulation GRAP2 TNF 16682409 1584052 Further , the deletion of NQO1 abolished *induced* c-Jun N-terminal kinase , Akt , [p38] , and p44/p42 mitogen activated protein kinase activation . Positive_regulation GRAP2 TNF 16783201 1573682 and PAF *increased* [p38] phosphorylation of neutrophil in WT but not that in Tnfrsf1a-/- mice . Positive_regulation GRAP2 TNF 16783201 1573690 Taken together with the *dependent* [p38] and NF-kappaB activation in primed neutrophil , we conclude that thermal injury induced priming effect of polymorphonuclear neutrophil is TNF-alpha and p38 dependent . Positive_regulation GRAP2 TNF 16875982 1593557 *activates* [p38-MAPK] , a stress-responsive kinase implicated in contractile depression and cardiac injury . Positive_regulation GRAP2 TNF 16875982 1593571 Under conditions of constant coronary flow , the [p38-MAPK] activation and contractile depression *induced* by , though attenuated , remained sensitive to the absence of MKK3 or the presence of SB203580 . Positive_regulation GRAP2 TNF 16875982 1593585 *activates* [p38-MAPK] in the intact heart and in isolated cardiac myocytes through MKK3 . Positive_regulation GRAP2 TNF 16937467 1609129 Interestingly , DA-9601 also selectively inhibited [p38] kinase phosphorylation *induced* by . Positive_regulation GRAP2 TNF 16953659 1646562 Activation of [p38] *required* in the nervous system because IT etanercept ( a TNF inhibitor ) given during adjuvant arthritis blocked spinal p38 phosphorylation and reduced clinical signs of adjuvant arthritis . Positive_regulation GRAP2 TNF 17151142 1732365 To fully evaluate the *role* of in myogenic activation of [p38] , we tried to determine whether p38 activation in differentiating myoblasts requires autocrine TNF-alpha , and whether forced activation of p38 rescues impaired myogenesis and regeneration in the p55 ( -/- ) p75 ( -/- ) soleus . Positive_regulation GRAP2 TNF 17241871 1690656 Chromatin immunoprecipitation analysis and immunofluorescence microscopy revealed that IL-10 mediated [p38] signaling inhibited *induced* recruitment of the ER-derived activating transcription factor (ATF)-6 to the grp-78 promoter likely through the blockade of ATF-6 nuclear translocation . Positive_regulation GRAP2 TNF 17276892 1691897 It also blocked the *induced* phosphorylation of [p38] and extracellular signal regulated kinase ( ERK ) , which are involved in regulating ICAM-1 production by TNF-alpha . Positive_regulation GRAP2 TNF 17683952 1858111 We found that alpha-MSH pretreatment inhibited *induced* MMP-13 expression and [p38] kinase phosphorylation in HTB-94 human chondrosarcoma cells . Positive_regulation GRAP2 TNF 17942934 1814209 Deletion of NQO2 also abolished *induced* c-Jun NH2-terminal kinase , Akt , [p38] , and p44/p42 mitogen activated protein kinase activation . Positive_regulation GRAP2 TNF 18316490 1886086 In DHF , mitogen activated kinase [p38] and calcium-calmodulin dependent kinase were disproportionally expressed/activated ( 50 % to 150 % ) , and *increased* in the late contracting ( higher-stress ) lateral versus septal wall . Positive_regulation GRAP2 TNF 18439578 1915605 On the other hand , lycopene did not affect *induced* [p38] and extracellular matrix regulated kinase1/2 ( ERK1/2 ) phosphorylation and interferon-gamma (IFN-gamma) induced signaling , suggesting that lycopene primarily affects TNF-alpha induced NF-kappaB signaling pathway . Positive_regulation GRAP2 TNF 18583302 1953148 and IL-1beta significantly *increase* [p38] expression . Positive_regulation GRAP2 TNF 18636175 1937265 Furthermore , glucosamine inhibited the *induced* phosphorylation of [p38MAPK] and NF-kappaB p65 , and the nuclear translocation of NF-kappaB in the cells . Positive_regulation GRAP2 TNF 18653803 1960512 PMA stimulated nSMase2 translocation was independent of p38 MAPK , and neither PKC inhibitors nor small interfering RNA had significant effects on *stimulated* [p38] MAPK activation , indicating that PKC-delta does not act through p38 MAPK in regulating nSMase2 . Positive_regulation GRAP2 TNF 18710428 2028213 These data suggest that interaction *leads* to the phosphorylation of Erk1/2 and [p38MAPK] and nuclear translocation of NF-kappaB , which is closely associated with the production and activation of MMP-9 in cultured CC cells of HuCTT-1 and CCKS-1 . Positive_regulation GRAP2 TNF 18805401 1981235 An analysis of distinct signaling pathway activations then revealed an *activation* of [p38] by , as well as a corresponding involvement of this mitogen activated protein kinase (MAPK) in the cytokine dependent inhibition of erythroid differentiation . Positive_regulation GRAP2 TNF 18948845 2053235 Hypertonic saline did not alter *induced* [p38] mitogen activated protein kinase phosphorylation or constitutive vascular endothelial growth factor expression , suggesting that the observed inhibition is not a generalized suppression of protein phosphorylation or cellular function . Positive_regulation GRAP2 TNF 19013539 2071197 Furthermore , Western blot analysis indicated that the *induced* phosphorylation of extracellular signal regulated kinase 1 and 2 ( ERK1/2 ) , [p38] and c-Jun N-terminal kinase (JNK) were strongly inhibited by DPT . Positive_regulation GRAP2 TNF 19234337 2079505 Analysis of downstream signals showed that inhibition of NAD(P)H oxidase partially inhibited NF-kappaB activation but did not reduce CCL2 mRNA stability or prevent *induced* phosphorylation of [p38MAPK] . Positive_regulation GRAP2 TNF 19429670 2106853 Ang II and clearly *enhanced* ERK and [p38MAPK] phosphorylation . Positive_regulation GRAP2 TNF 19643162 2132348 SOCS-3 inhibited *induced* phosphorylation of the mitogen activated protein kinases ERK1/2 , [p38] and JNK in INSr3 # 2 cells and in primary rat islets . Positive_regulation GRAP2 TNF 19648110 2138340 Repression of *induced* [p38] MAPK phosphorylation , NF-kappaB dependent transcription , and IL-8 expression by dexamethasone are sensitive to transcriptional or translational inhibitors . Positive_regulation GRAP2 TNF 19826422 2154671 This impaired A20 induction in E1A/Ras MEFs was not because of the stabilisation of p53 or a defective *induced* [p38] and Jun N-terminal kinase (JNK) signalling . Positive_regulation GRAP2 TNF 19838780 2216990 In the present study , production of and MIP-2 and *activation* of extracellular signal regulated kinases ( ERK ) 1/2 , c-Jun amino terminal kinases (JNK) and [p38] in RAW264.7 cells were measured . Positive_regulation GRAP2 TNF 20004242 2199802 In contrast , [p38delta] *activation* by ultraviolet radiation , hyperosmotic shock , anisomycin or by is mediated by MKK3 . Positive_regulation GRAP2 TNF 20484867 2276258 NAC inhibited *induced* phosphorylation of JNK and [p38] but not NF-kappaB . Positive_regulation GRAP2 TNF 20609399 2321710 Furthermore , both [p38] and JNK were *activated* by in human synovial fibroblasts isolated from RA patients ( RASF ) . Positive_regulation GRAP2 TNF 20646342 2292544 Effects of budesonide on [P38] MAPK activation , apoptosis and IL-8 secretion , *induced* by and Haemophilus influenzae in human bronchial epithelial cells . Positive_regulation GRAP2 TNF 20837364 2368509 In a cell line of canine epidermal keratinocyte , CPEK , stimulation with *induced* not only the activation of nuclear factor-kappa B ( NF-?B ) but also the phosphorylation of c-Jun-N-terminal kinase (JNK) and mitogen activated protein kinase [p38] ( p38 ) . Positive_regulation GRAP2 TNF 21181166 2499597 IL-1ß and *activated* the intracellular mitogen activated protein kinases ( MAPKs ) : p44/42 MAPK , [p38] , and c-Jun N-terminal kinase (JNK) as well as nuclear factor-?B ( NF-?B ) in osteoblasts . Positive_regulation GRAP2 TNF 21777697 2509919 However , ZLJ-6 did not affect *induced* extracellular signal regulated kinases ( ERK1/2 ) , c-Jun N-terminal kinases (JNK) and [p38] phosphorylation . Positive_regulation GRAP2 TNF 21894146 2510855 Vehicle and untreated NTN exhibited heavy proteinuria and glomerular thrombosis at 24 h with P-selectin and fibrin immunostaining within capillaries , glomerular macrophage and T cell infiltration , *activation* of JNK and [p38] MAPK signalling , and upregulation of glomerular mRNA levels of pro-inflammatory molecules ( , NOS2 , MMP-12 and CCL2 ) . Positive_regulation GRAP2 TNF 21990224 2493496 In this setting , *increases* [p-p38] phosphorylation and chemosensitivity while further enhancing IL-8 production . Positive_regulation GRAP2 TNF 22198289 2558670 Stimulation of human umbilical vein endothelial cells ( HUVEC ) with IL-1ß or ( CHX ) was found to *enhance* the phosphorylation of [p38] and Jun-N-terminal kinase (JNK) in a time dependent fashion , but did not affect the time dependent phosphorylation of extracellular signal regulated kinase . Positive_regulation GRAP2 TNF 22294037 2586297 In this article , we report that nocodazole , a widely used microtubule interfering agent , antagonized UV- or *induced* [p38] activation , even though this drug by itself weakly activated p38 . Positive_regulation GRAP2 TNF 22294037 2586299 The inhibition by nocodazole of *induced* [p38] activation was abolished by ERK-specific inhibitor U0126 . Positive_regulation GRAP2 TNF 22510965 2584224 Moreover , yangonin did not inhibit *induced* activation of [p38] , but it significantly impaired activation of extracellular signal regulated kinase 1/2 and stress activated protein kinase/c-Jun NH ( 2 ) -terminal kinase . Positive_regulation GRAP2 TNF 22554771 2608577 An antioxidant drug , N-acetyl-l-cysteine significantly inhibited *induced* phosphorylation of [p38] and JNK . Positive_regulation GRAP2 TNF 22711527 2670034 Stimulation of cells with *enhanced* ASK1 , JNK , and [p38] activation . Positive_regulation GRAP2 TNF 22762513 2639493 *induced* JNK and [p38] activations , which were involved in ICAM-1 expression , were significantly inhibited with DTD serum treatment by 10-50 % on HUVEC . Positive_regulation GRAP2 TNF 23258237 2741343 specifically *activated* [p38a] but not other p38 isoforms and suppression of p38a by an siRNA resulted in further amplification of the TNF-a effect . Positive_regulation GRAP2 TNF 23552557 2714209 Our results show that MLK4ß inhibits sorbitol- and *induced* activation of [p38] . Positive_regulation GRAP2 TNF 23632129 2790733 LAR also enhanced *induced* [phospho-p38] and phospho-AKT expression , but inhibited the expression of phospho-JNK and nuclear translocation of NF-?Bp65 in RA synovial fibroblasts . Positive_regulation GRAP2 TNF 23729444 2801852 GILZ overexpression also inhibited induced *activation* of [p38] , ERK , and JNK MAPKs , as well as increased expression of the MAPK inhibitory phosphatase , MKP-1 . Positive_regulation GRAP2 TNF 24489443 2884787 Finally , by investigating the intracellular pathways involved in promoting the VEC release of cytokines/chemokines , which are targeted by natural anti-inflammatory compounds , we documented that aLipoic acid significantly counteracted *induced* NF-?B and [p38/MAPK] activation while the effects of Ginkgo biloba appeared to be predominantly mediated by Akt . Positive_regulation GRAP2 TNF 8941662 399294 In contrast , JNK and [p38] are only *activated* by IL-1 or , suggesting that these kinases participate in the induction of the catabolic program in cartilage . Positive_regulation GRAP2 TNF 9006914 410769 stimulation of endothelial cells induces transient phosphorylation of both ATF-2 and c-JUN and *induces* marked activation of the c-JUN N-terminal kinase ( JNK1 ) and [p38] but not extracellular signal regulated kinase ( ERK1 ) . Positive_regulation GRAP2 TNF 9139689 428180 and hydrogen peroxide , in contrast , led to NF-kappaB activation but only modestly *stimulated* [p38] . Positive_regulation GRAP2 TNF 9528756 496020 These data show that anisomycin behaves like a true signalling agonist and suggest that the anisomycin desensitized signalling component ( s ) is not involved in JNK/SAPK or [p38/RK] *activation* by EGF , bFGF , , or TPA but may play a significant role in UV- and hyperosmolarity stimulated responses . Positive_regulation GRAP2 TNF 9706165 526262 Both LPS and *induced* activation of [p38] in HMVECs . Positive_regulation GRAP2 TNFSF10 12969966 1185566 Among the intracellular pathways investigated , significantly *stimulated* the extracellular signal regulated kinase 1/2 ( ERK1/2 ) but not the [p38/mitogen] activated protein kinase (MAPK) or the c-Jun NH2-terminal kinase (JNK) pathway . Positive_regulation GRAP2 TNFSF10 21454681 2422401 Analyzing non-apoptotic signaling pathways , we found that and CD95L *activate* JNK and [p38] within 15 min . cFLIP variants and different caspase inhibitors blocked late death ligand induced JNK or p38 MAPK activation suggesting that these responses are secondary to cell death . Positive_regulation GRAP2 TNFSF10 21454681 2422558 Knockdown of cFLIP isoforms in primary human keratinocytes enhanced CD95L- and *induced* NF-?B activation , and JNK and [p38] activation , underscoring the regulatory role of cFLIP for these DR-mediated signals . Positive_regulation GRB2 EPHB2 16705167 1560777 Tcptp-/- macrophages also have increased tyrosine phosphorylation and recruitment of a [Grb2/Gab2/Shp2] complex to the CSF-1R and enhanced *activation* of after CSF-1 stimulation , which are important molecular events in CSF-1 induced differentiation . Positive_regulation GRB2 EPHB2 9710602 526846 The arsenite induced tyrosine phosphorylation of Shc , enhancement of Shc and [Grb2] interactions , and *activation* of were all drastically reduced by treatment of cells with either the general growth factor receptor poison suramin or the EGFR-selective inhibitor tyrphostin AG1478 . Positive_regulation GRB2 TNF 14687710 1179598 Thus , these results suggest that over-expression of [GRB2] and FLICE2 in RA synovium is *caused* by inducibility differentially regulated in RA synoviocytes and provide potential pathogenic roles of these genes in the hyperplasia of the RA synovium . Positive_regulation GRB7 EFNB1 12223469 1012232 Stimulation of endogenous EphB1 in embryonal carcinoma P19 cells with its ligand *increased* its association with [Grb7] , which is consistent with a role for the autophosphorylation of EphB1 . Positive_regulation GREB1 TNF 21784129 2476457 *induced* luciferase expression in the absence and presence of estradiol and also augmented expression of the estrogen regulated genes c-fos , [GREB1] , and progesterone receptor . Positive_regulation GRHPR SLC6A2 18831547 1981633 The heterocycles 2-methyl-2-oxazoline ( mox ) and 2-methyl-2-thiazoline ( mth ) react with [Ph2PCl] under mild conditions , in the *presence* of which promotes their phosphorylation by stabilization of their enamino tautomers mox ( e ) and mth ( e ) , respectively , and which also behaves as HCl scavenger . Positive_regulation GRIA1 EPHB2 23276632 2775376 As a whole , the studies demonstrate that E2 enhances spine density in both the PFC and SSC , and that E2 enhances excitatory glutamatergic synapse formation in cortical neurons via a rapid extranuclear ER-mediated signaling mechanism that involves *up-regulation* of [GluR1] and mediation by Akt and signaling pathways . Positive_regulation GRIA1 GRIK2 8967991 402415 In contrast , we demonstrate herein that EB potently inhibits glutamate evoked currents *mediated* by the kainate-type receptor ( IC50 150 nM ) as well as the AMPA-type receptor [GluR1] ( IC50 = 220 nM ) in whole-cell patch clamp recordings from transfected human embryonic kidney 293 cells . Positive_regulation GRIK2 FOS 11925568 926739 Moreover , *regulates* the expression of the kainic acid receptor [GluR6] and brain derived neurotrophic factor (BDNF) , both in vivo and in vitro . Positive_regulation GRIN2A CAPN8 15590920 1346091 We examined the ability of postsynaptic density-95 (PSD-95) protein to alter the *mediated* cleavage of [NR2A] and NR2B . Positive_regulation GRIN2A NT5E 14720220 1197765 Western blots revealed the *induction* of [NR2A] by . Positive_regulation GRIN2B CAPN8 15590920 1346105 We examined the ability of postsynaptic density-95 (PSD-95) protein to alter the *mediated* cleavage of NR2A and [NR2B] . Positive_regulation GRIN2B CAPN8 22523092 2637397 Moreover , combined inhibition and STEP inactivation *reduced* extrasynaptic , while increasing synaptic [GluN2B] expression in the YAC128 striatum . Positive_regulation GRIN2B EPHB2 17972914 1826708 activation stimulated phosphorylation of eukaryotic translation initiation factor 4E ( eIF4E ) and *augmented* [NMDA receptor 2B (NR2B)] protein levels . Positive_regulation GRIN2B PLAT 17673549 1781177 forms a complex with NR2B and is *necessary* for binding [NR2B] to postsynaptic density-95 , allowing for NR activation and membrane anchoring . Positive_regulation GRIP1 MAP2K6 20346402 2281728 [GRIP1] increased the E ( 2 ) -dependent ERE activation in the *presence* of ERalpha and constitutive-active . Positive_regulation GRK5 ADRB2 19092051 2036030 However , tyrosyl phosphorylation of GRK5 was not necessary for GRK5 mediated phosphorylation of the , even though beta(2)-adrenergic receptor activation *promoted* tyrosyl phosphorylation of [GRK5] in smooth muscle cells . Positive_regulation GRK5 ADRB2 19092051 2036032 We conclude that GRK5 tyrosyl phosphorylation is required for the *activation* of [GRK5] by the PDGFRbeta , but not by the , and that by activating GRK5 , the PDGFRbeta triggers its own desensitization . Positive_regulation GRK5 CTGF 23778361 2824129 In conclusion , this study uncovers a novel mechanism controlling ß-AR responsiveness in cardiomyocytes involving *mediated* regulation of [GRK5] . Positive_regulation GRK5 MIP 12592402 1064318 We also show that lipopolysaccharide (LPS) activated signaling through the Toll-like receptor (TLR)-4 pathway transcriptionally downregulates the expression of GRK2 and [GRK5] in *response* to . Positive_regulation GRK6 TNF 23979726 2841326 And neutralized by antibody intrathecal injection *up-regulated* [GRK6] expression and attenuated the mechanical allodynia and heat hyperalgesia in CCI model . Positive_regulation GRM1 EPHB2 18045912 1832897 These effects were mediated by activation of mGlu5 , but not [mGlu1] , and were *dependent* on activation . Positive_regulation GRM1 SLC1A6 19289926 2046805 At cerebellar climbing fiber-Purkinje cell synapse , EAAT4 and metabotropic glutamate receptor 1 ( mGluR1 ) are closely expressed in surrounding postsynaptic locations , suggesting that may *regulate* [mGluR1] activation . Positive_regulation GRM5 EPHB2 18045912 1832898 These effects were mediated by activation of [mGlu5] , but not mGlu1 , and were *dependent* on activation . Positive_regulation GRM5 EPHB2 24167026 2889714 These data indicate that [Homer1c-mGluR5] interactions are necessary for mGluR dependent LTP , and that mGluR1/5 dependent LTP *involves* PI3K and activation . Positive_regulation GRP CAPN8 20823585 2318532 Moreover , we demonstrated that IPA triggered endoplasmic reticulum ( ER ) stress , as shown by changes in cytosol-calcium level , *activation* of and caspase-12 , and up-regulation of [glucose regulated protein 78 (GRP78)] and growth arrest DNA damage-inducible gene 153 ( GADD153 ) . Positive_regulation GRP EPHB2 22418436 2587991 Both p38 MAPK promoted [glucose regulated protein 78 (GRP78)] expression and sustained high basal *activation* of PI3K/Akt and are involved in the cytoprotective function of p190Met ( NC ) . Positive_regulation GRP MAP2K6 22418436 2588000 Both p38 MAPK promoted [glucose regulated protein 78 (GRP78)] expression and sustained high basal *activation* of PI3K/Akt and are involved in the cytoprotective function of p190Met ( NC ) . Positive_regulation GSDMA TNF 22585037 2643397 These results , taken together , indicated that in mouse skin keratinocytes , [Gsdma3] expression could be *regulated* by . Positive_regulation GSK3B AXIN2 10490650 645607 We have identified a novel self-interaction domain in axin and have shown that formation of an regulatory complex in vivo is *critical* for axis formation and [GSK-3beta] activity . Positive_regulation GSK3B AXIN2 10490650 645609 Based on these data , we propose that the complex may directly *regulate* [GSK-3beta] enzymatic activity in vivo . Positive_regulation GSK3B CCND1 18809569 1987367 Double-strand break dependent degradation *requires* ATM and [GSK3beta] , which in turn mediate cyclin D1 phosphorylation . Positive_regulation GSK3B CTGF 15319369 1303751 Furthermore , *stimulated* phosphorylation and activation of [GSK-3beta] . Positive_regulation GSK3B CTGF 17327498 1747876 In high ambient glucose basal PKC-zeta and GSK3beta phosphorylation levels are selectively increased and *stimulated* PKC-zeta and [GSK3beta] phosphorylation was impaired . Positive_regulation GSK3B EPHB2 15476703 1319546 Indeed , [GSK-3beta] phosphorylation occurred in response to kainic acid exclusively in the affected hippocampus , but not as a *consequence* of activation . Positive_regulation GSK3B EPHB2 16150462 1475622 The activity of [GSK3beta] , a downstream target of these pathways , was negatively *regulated* by the activation of both and PI3K/Akt . Positive_regulation GSK3B EPHB2 16810687 1600052 PKC also links P2 receptors to ERK in astrocytes , but inhibition of signaling did not *block* phosphorylation of [Ser9-GSK3beta] stimulated by P2 receptors . Positive_regulation GSK3B EPHB2 18701453 1979670 Incubation with selective kinase inhibitors showed that high glucose- and high insulin induced laminin beta1 synthesis and phosphorylation of [GSK3beta] were *dependent* on PI 3-kinase , , and mTOR . Positive_regulation GSK3B IRS4 19029952 2029403 Once expressed , as well as binding to E1A and the insulin receptor , remains tyrosine phosphorylated and constitutively associates with the regulatory p85 subunit of phosphoinositide 3 kinase , *resulting* in the phosphorylation of Akt ( causing activation ) and [GSK-3beta] ( causing inhibition ) . Positive_regulation GSK3B LBP 16645641 1672015 In this study , we demonstrate that the APLP2-ICDs interact with ( CP2 ) transcription factor in the nucleus and *induce* the expression of [glycogen synthase kinase 3beta] ( GSK-3beta ) , which has broad ranged substrates such as tau- and beta-catenin . Positive_regulation GSK3B RCAN1 16649988 1557378 ( DSCR1 or Adapt78 ) *stimulates* expression of [GSK-3beta] . Positive_regulation GSK3B RCAN1 16649988 1557382 We also show that [GSK-3beta] is *regulated* by at a post-transcriptional level . Positive_regulation GSK3B RCAN1 16649988 1557385 This suggests that might *induce* production of [GSK-3beta] in vivo . Positive_regulation GSK3B RCAN1 16649988 1557389 While can *regulate* calcineurin and [GSK-3beta] , it has also been shown that calcineurin and GSK-3beta can regulate RCAN1s . Positive_regulation GSK3B TNF 16601113 1568692 Interestingly , inhibition of GSK-3beta by antisense oligonucleotides or pharmacological agent ( 10 mm lithium ) potentiated *induced* expression of IL-6 and MCP-1 by 2-6-fold suggesting that inhibition of [GSK-3beta] under inflammatory conditions ( exposure to TNF-alpha and IL-1beta ) may contribute to enhanced cytokine expression . Positive_regulation GSK3B TNF 17158207 1694190 Western blot analysis of L6 cell lysates demonstrated impaired insulin stimulated phosphorylation of Akt , serine/arginine-rich protein 40 , and [glycogen synthase kinase 3beta] in *response* to and the short chain C6 ceramide analog . Positive_regulation GSK3B TNFSF10 14617795 1168547 Importantly , TRAIL stimulation increased GSK-3beta tyrosine phosphorylation at Y216 , suggesting that [GSK-3beta] is *activated* by . Positive_regulation GSPT1 CCND1 22024187 2507991 *regulates* the [G1-to-S phase transition] . Positive_regulation GSPT1 EPHB2 15781236 1385458 The results indicate that the up-regulation of caveolin-2 in response to insulin activates the downstream signal cascades in the cell cycle , chiefly the increased phosphorylation of ERK , the nuclear translocation of phosphorylated , and the subsequent *activation* of [G0/G1 to S phase transition] of the cell cycle . Positive_regulation GSPT1 TCN1 18959821 1982906 Interestingly , the over-expression of *promoted* the [G(1)- to S-phase transition] of the cell cycle , which was delayed by the deficiency of ERK1/2 signaling in fibroblast cells . Positive_regulation GSPT1 TCN1 18959821 1982908 Taken together , our findings revealed that was *involved* in the mitogen activated ERK1/2 signaling pathway and positively regulated [G(1)- to S-phase transition] of the cell cycle . Positive_regulation GSPT2 CCND1 22024187 2507992 *regulates* the [G1-to-S phase transition] . Positive_regulation GSPT2 EPHB2 15781236 1385459 The results indicate that the up-regulation of caveolin-2 in response to insulin activates the downstream signal cascades in the cell cycle , chiefly the increased phosphorylation of , the nuclear translocation of phosphorylated ERK , and the subsequent *activation* of [G0/G1 to S phase transition] of the cell cycle . Positive_regulation GSPT2 TCN1 18959821 1982907 Interestingly , the over-expression of *promoted* the [G(1)- to S-phase transition] of the cell cycle , which was delayed by the deficiency of ERK1/2 signaling in fibroblast cells . Positive_regulation GSPT2 TCN1 18959821 1982909 Taken together , our findings revealed that was *involved* in the mitogen activated ERK1/2 signaling pathway and positively regulated [G(1)- to S-phase transition] of the cell cycle . Positive_regulation GSTA4 TNF 11884396 937247 In transient transfections , IL-6 and EGF , but not , *transactivated* the human [GSTA4] ( hGSTA4 ) promoter cloned upstream of the luciferase reporter gene suggesting that IL-6 and EGF up-regulated hGSTA4 at a transcriptional level , whereas TNFalpha could rather act at a post-transcriptional level . Positive_regulation GSTP1 TNF 14555224 1153069 *induced* [GSTP1-1] promoter activity was also inhibited by curcumin as shown by reporter gene assay . Positive_regulation GSTP1 TNF 15013838 1220710 Moreover , treatment as well as cotransfection of NF-kappaB signaling pathway intermediates *induced* an activation of the [GSTP1-1] gene promoter in K562 cells . Positive_regulation GSTT2 ARSA 9729437 530147 Gastric [GSTT2-2] levels were induced by ibuprofen ( 1.6x ) and indomethacin ( 1.5x ) , and colonic levels were *induced* by ( 1.7x ) . Positive_regulation GTF2B EDN2 12368904 998447 A preferential role for Cdk9 was shown in [RNA polymerase II] phosphorylation and growth *induced* by , using pharmacological and dominant negative inhibitors . Positive_regulation GTF2B IL1B 12649265 1080002 induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and *stimulated* [RNA polymerase II] binding to the COX-2 promoter , COX-2 transcription , COX-2 protein synthesis , and prostaglandin E2 ( PGE2 ) release . Positive_regulation GTF2B TLR7 21849441 2486176 We show that the TLR2 ligand PAM3CSK4 activated virus transcription in macrophages and that NR signaling repressed both basal and *induced* [HIV-1 transcription] . Positive_regulation GTF2B TNF 18688044 1961007 *induced* inflammatory gene expression , H3K4me2 levels , and recruitment of [RNA polymerase II] at the gene promoters were also enhanced in db/db VSMCs , demonstrating the formation of open chromatin poised for transcriptional activation in diabetes . Positive_regulation GTF2B TNF 19734226 2139666 Furthermore , chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and [RNA polymerase II] to the CXCL8 promoter of asthmatic HASM cells both in the *presence* and absence of stimulation . Positive_regulation GTF2B TNF 7681592 214299 We conclude that at specific TNF/soluble TNF-receptor dimer ratios , *induced* [HIV-1 transcription] and expression can be limited in vitro . Positive_regulation GTF2F1 EDN2 12368904 998450 A preferential role for Cdk9 was shown in [RNA polymerase II] phosphorylation and growth *induced* by , using pharmacological and dominant negative inhibitors . Positive_regulation GTF2F1 IL1B 12649265 1080003 induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and *stimulated* [RNA polymerase II] binding to the COX-2 promoter , COX-2 transcription , COX-2 protein synthesis , and prostaglandin E2 ( PGE2 ) release . Positive_regulation GTF2F1 TNF 18688044 1961008 *induced* inflammatory gene expression , H3K4me2 levels , and recruitment of [RNA polymerase II] at the gene promoters were also enhanced in db/db VSMCs , demonstrating the formation of open chromatin poised for transcriptional activation in diabetes . Positive_regulation GTF2F1 TNF 19734226 2139667 Furthermore , chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and [RNA polymerase II] to the CXCL8 promoter of asthmatic HASM cells both in the *presence* and absence of stimulation . Positive_regulation GTF2F2 EDN2 12368904 998453 A preferential role for Cdk9 was shown in [RNA polymerase II] phosphorylation and growth *induced* by , using pharmacological and dominant negative inhibitors . Positive_regulation GTF2F2 IL1B 12649265 1080004 induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and *stimulated* [RNA polymerase II] binding to the COX-2 promoter , COX-2 transcription , COX-2 protein synthesis , and prostaglandin E2 ( PGE2 ) release . Positive_regulation GTF2F2 TNF 18688044 1961009 *induced* inflammatory gene expression , H3K4me2 levels , and recruitment of [RNA polymerase II] at the gene promoters were also enhanced in db/db VSMCs , demonstrating the formation of open chromatin poised for transcriptional activation in diabetes . Positive_regulation GTF2F2 TNF 19734226 2139668 Furthermore , chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and [RNA polymerase II] to the CXCL8 promoter of asthmatic HASM cells both in the *presence* and absence of stimulation . Positive_regulation GTF2H1 TNF 16874302 1600736 Upon *stimulation* of the cells by , NF-kappaB and [TFIIH] are rapidly recruited to the promoter together with additional Mediator and RNAP II , but CDK8 is lost . Positive_regulation GTF2H2 TNF 16874302 1600737 Upon *stimulation* of the cells by , NF-kappaB and [TFIIH] are rapidly recruited to the promoter together with additional Mediator and RNAP II , but CDK8 is lost . Positive_regulation GTF2H3 TNF 16874302 1600738 Upon *stimulation* of the cells by , NF-kappaB and [TFIIH] are rapidly recruited to the promoter together with additional Mediator and RNAP II , but CDK8 is lost . Positive_regulation GTF2H4 TNF 16874302 1600739 Upon *stimulation* of the cells by , NF-kappaB and [TFIIH] are rapidly recruited to the promoter together with additional Mediator and RNAP II , but CDK8 is lost . Positive_regulation GTF2I EPHB2 10648599 662103 These results suggest that *regulates* the activity of [TFII-I] by direct phosphorylation . Positive_regulation GUCA2A IL1B 10875263 707275 Dimethyl-PGE2 ( 1.4 x 10 ( -5 ) M ) or ( 2.5 x 10 ( -10 ) M ) *induced* a 3-fold increase in G-IR in the lumen , whereas the degranulator compound bromolasalocid did not stimulate [guanylin] secretion . Positive_regulation GUCY2D CYP24A1 17535892 1751586 Further , [LCA] *induces* mRNA gene expression in the kidney of vitamin D-deficient rats . Positive_regulation GUCY2D FAS 19054763 2023915 [LCA] also *induced* increased localization to the plasma membrane and generated increased reactive oxygen species compared with ent-LCA . Positive_regulation GUCY2D S100B 10336449 615422 In addition to recombinant bovine GCAPs , constitutively active mutants of GCAPs that activate retGC-1 in a [Ca2+ ] -independent manner and bovine brain that *activates* [retGC-1] in the presence of approximately 10 microM [Ca2+ ] were used to investigate whether these activations take place through a similar mechanism , and whether [Ca2+ ] is directly involved in the dimerization . Positive_regulation GUCY2D S100B 10529237 654491 However , at micromolar concentrations of Ca ( 2+ ) , [ROS-GC1] is *stimulated* by [ also named calcium dependent ( CD ) GCAP ] . Positive_regulation GUCY2D S100B 10529237 654494 The present study shows that the E786D mutation has no effect on the basal catalytic activity of [ROS-GC1] and on its *activation* by GCAP1 and ; Positive_regulation GUCY2D S100B 11952085 930448 At nanomolar Ca2+ concentrations , [ROS-GC1] is *activated* by GCAPs and at micromolar Ca2+-concentrations , by and neurocalcin . Positive_regulation GUCY2D S100B 24723847 2932041 Unlike GCAPs , *stimulates* [ROS-GC] activity when Ca ( 2+ ) is bound . Positive_regulation GYPB FAS 16000635 1430743 protein levels and cleaved caspase-8 *increased* in [MNs] after injury . Positive_regulation GYS1 CCND1 23632004 2838298 In primary culture VSMCs , sustained stimulation with tPA induced collagen type I upregulation and triggered sequential signaling events involving Akt , extracellular signal regulated kinases 1/2 ( ERK1/2 ) , [glycogen synthase kinase-3 (GSK3)-ß] phosphorylation , and *induction* . Positive_regulation GYS1 EPHB2 8940056 398802 The temporal relationship between the activation of ERK , JNK , p38 and the downstream elements p90 ( rsk ) and PP-1 in vivo suggest that JNK , but neither nor p38 MAPKs , *mediates* insulin activation of [glycogen synthase] in vivo . Positive_regulation GYS1 FOXO1 24577092 2920029 We report here that *enhances* [glycogen synthase kinase 3ß (GSK3ß)] activity which in turn represses MYOGENIN activity . Positive_regulation GYS1 LRRN2 8289829 247966 Increased dosage of *results* in increased activity of [glycogen synthase] and a corresponding hyperaccumulation of glycogen . Positive_regulation GYS1 PLAT 23632004 2838299 In primary culture VSMCs , sustained stimulation with induced collagen type I upregulation and *triggered* sequential signaling events involving Akt , extracellular signal regulated kinases 1/2 ( ERK1/2 ) , [glycogen synthase kinase-3 (GSK3)-ß] phosphorylation , and cyclin D1 induction . Positive_regulation GYS1 RCAN1 21876249 2516028 Increased expression of also *causes* upregulation of [glycogen synthase kinase-3ß (GSK3ß)] , a tau kinase . Positive_regulation GYS2 CCND1 23632004 2838300 In primary culture VSMCs , sustained stimulation with tPA induced collagen type I upregulation and triggered sequential signaling events involving Akt , extracellular signal regulated kinases 1/2 ( ERK1/2 ) , [glycogen synthase kinase-3 (GSK3)-ß] phosphorylation , and *induction* . Positive_regulation GYS2 EPHB2 8940056 398803 The temporal relationship between the activation of ERK , JNK , p38 and the downstream elements p90 ( rsk ) and PP-1 in vivo suggest that JNK , but neither nor p38 MAPKs , *mediates* insulin activation of [glycogen synthase] in vivo . Positive_regulation GYS2 FOXO1 24577092 2920031 We report here that *enhances* [glycogen synthase kinase 3ß (GSK3ß)] activity which in turn represses MYOGENIN activity . Positive_regulation GYS2 LRRN2 8289829 247967 Increased dosage of *results* in increased activity of [glycogen synthase] and a corresponding hyperaccumulation of glycogen . Positive_regulation GYS2 PLAT 23632004 2838301 In primary culture VSMCs , sustained stimulation with induced collagen type I upregulation and *triggered* sequential signaling events involving Akt , extracellular signal regulated kinases 1/2 ( ERK1/2 ) , [glycogen synthase kinase-3 (GSK3)-ß] phosphorylation , and cyclin D1 induction . Positive_regulation GYS2 RCAN1 21876249 2516029 Increased expression of also *causes* upregulation of [glycogen synthase kinase-3ß (GSK3ß)] , a tau kinase . Positive_regulation GZMA IL1B 18951048 1989235 Moreover , murine [GzmA] and GzmA ( + ) cytotoxic T lymphocytes ( CTLs ) *induce* from primary mouse macrophages , and GzmA ( -/- ) mice resist lipopolysaccharide induced toxicity . Positive_regulation GZMB FAS 16455348 1522296 Evidence for death of the keratinocytes through ( 1 ) drug-specific cytotoxicity with the [perforin-granzyme B-mediated] killing and ( 2 ) *activation* of on keratinocytes have provided explanations for the sloughing of skin . Positive_regulation GZMB IL1B 19159824 2027451 Our findings suggest that RAE *induces* TLR-4 expression and intracellular [granzyme-B] in treated splenocytes while RAE stimulated , IL-6 , and TNF-alpha in human PBMCs . Positive_regulation GZMB TNF 19159824 2027450 Our findings suggest that RAE *induces* TLR-4 expression and intracellular [granzyme-B] in treated splenocytes while RAE stimulated IL-1beta , IL-6 , and in human PBMCs . Positive_regulation GZMB TNF 19458908 2115467 *induced* MCP-1 , RANTES , and [granzyme B] production in cultured synovial cells from RA patients . Positive_regulation H19 MMP28 9573338 502398 Enzyme activity of MMP-C31 and [-H19] was *inhibited* by human tissue inhibitor of MMPs (TIMP)-1 , TIMP-2 and synthetic inhibitors , BB94 and CT543 , indicating that the catalytic sites of these C. elegans MMPs are structurally closely related with those of mammalian MMPs . Positive_regulation H19 MMP7 9573338 502413 Enzyme activity of MMP-C31 and [-H19] was *inhibited* by human tissue inhibitor of MMPs (TIMP)-1 , TIMP-2 and synthetic inhibitors , BB94 and CT543 , indicating that the catalytic sites of these C. elegans MMPs are structurally closely related with those of mammalian MMPs . Positive_regulation H1F0 FAS 10336417 615335 In vitro kinase assay of PKCalpha or epsilon phosphotransferase activity demonstrated that ligation *inhibited* the ability of PKCalpha to phosphorylate [histone H1] as substrate but did not inhibit epsilon isozyme activity . Positive_regulation H1F0 PLAU 15188364 1256665 Plasminogen bound to the cytoskeleton and nuclear structures , was *activated* to plasmin by either tissue-type or , and degraded [histone H1] , thereby facilitating internucleosomal DNA cleavage by Dnase1 . Positive_regulation H2AFX ARSA 16861926 1600598 The *induction* of phosphorylation of [H2AX] on Ser 139 by was markedly attenuated in the presence of N-acetyl-L-cysteine , a scavenger of reactive oxygen species ( ROS ) . Positive_regulation H2AFX CCND1 19901524 2166082 Likewise , cyclin E , but not cyclin B1 and , also *induced* the [gamma-H2AX] focus formation , suggesting that these DNA lesions may be induced via aberrant DNA replication process . Positive_regulation H2AFX TNF 24036252 2857187 The ensuing Slug dependent serine 139 phosphorylation of the DNA damage sensor [H2AX] in breast cancer stem cells *induces* and IL-8 mRNAs , whose stability is enhanced by cytoplasmic ß-catenin . Positive_regulation H2AFX TNFSF10 22753480 2639465 In contrast , HSP90 inhibition by geldanamycin markedly enhances *induced* DNA-PK and [H2AX] activation . Positive_regulation H6PD TNF 8823382 384890 and IL-1 alpha induced an *increase* in [GDH] promoter activity in C8S ( an astrocytic cell line ) transfected with constructs containing 5 ' flanking genomic sequences of GDH driving the expression of a reporter gene . Positive_regulation HAMP IL1B 15684062 1370852 We show that incubating murine hepatocytes with IL-6 , IL-1alpha , and strongly *stimulates* [hepcidin] transcription . Positive_regulation HAMP IL1B 16198622 1496322 *Upregulation* of [hepcidin] by in human hepatoma cell lines . Positive_regulation HAMP IL1B 16198622 1496323 Although the induction of hepcidin by an inflammatory cytokine interleukin-6 (IL-6) seems to have been confirmed , it is still controversial whether , also known as an inflammatory cytokine , *regulates* [hepcidin] expression . Positive_regulation HAMP PGC 23438894 2760227 *regulates* hepatic [hepcidin] expression and iron homeostasis in response to inflammation . Positive_regulation HAMP PGC 23438894 2760229 Consistently , overexpression of in HepG2 or HuH7 cells also *suppresses* [HAMP] expression and reduces iron accumulation . Positive_regulation HAMP PGC 23438894 2760232 Our data suggest a critical *role* for in the regulation of hepatic [HAMP] expression and iron homeostasis under inflammatory circumstances . Positive_regulation HAMP TF 17540841 1784187 Iron *regulates* [hepcidin] synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4 . Positive_regulation HAMP TF 19254564 2045163 Gao et al. ( 2009 ) make the key discovery that the regulation of [hepcidin] in response to holotransferrin *requires* the interaction between HFE and . Positive_regulation HAMP TF 19254567 2045168 Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for *induced* [hepcidin] expression . Positive_regulation HAMP TF 20634490 2334906 Implications for *dependent* [hepcidin] regulation . Positive_regulation HAMP TF 20956801 2375980 To investigate the *role* of in the regulation of [hepcidin] expression by these factors in vivo , we employed the hypotransferrinemic ( hpx ) mouse . Positive_regulation HAMP TF 21245482 2397939 Hfe and are *involved* in the homeostatic regulation of [hepcidin] and their disruption causes hereditary hemochromatosis (HH) . Positive_regulation HAMP TNF 16221503 1517853 Under serum-free conditions only *increased* [HAMP] mRNA levels . Positive_regulation HAMP TNF 16221503 1517857 *regulates* the mRNA levels of [HAMP] , IREG1 , DMT1 and TfR2 in cultured hepatocytes from both iron loaded and control animals . Positive_regulation HAMP TNF 17255318 1691062 These results contrast with previous data demonstrating that [hepcidin] levels are directly *regulated* by interleukin-6 but not by . Positive_regulation HAS1 EPHB2 17493932 1761632 The activated then *increases* the phosphorylation of [HAS1] , HAS2 , and HAS3 . Positive_regulation HAS1 HAS3 17324121 1733756 Analysis of HAS ( hyaluronan synthase ) and HYAL ( hyaluronidase ) mRNA expression showed that PDGF-BB treatment *induced* a 3-fold increase in the already high level of HAS2 mRNA , and increases in [HAS1] and HYAL1 mRNA , whereas the levels of and HYAL2 mRNA were not affected . Positive_regulation HAS1 IL1B 10566653 567478 Expression of [hyaluronan synthase] messenger ribonucleic acids and their *induction* by in human orbital fibroblasts : potential insight into the molecular pathogenesis of thyroid associated ophthalmopathy . Positive_regulation HAS1 IL1B 11389868 822414 These results suggest that TNF-alpha and *regulate* [HAS] expression , and consequently may result in an accumulation of HA and an increase in HA of a lower molecular-weight . Positive_regulation HAS1 IL1B 15649434 1363887 The expression of [HAS-1] , -2 , and -3 mRNAs was significantly *augmented* by . Positive_regulation HAS1 IL1B 15649434 1363888 These results indicate that [HAS] in the uterine cervix is *regulated* in a complex manner by , progesterone , and low-molecular-weight hyaluronan , of which changes in the cervical tissue and serum closely participate in uterine cervical ripening and/or inflammation . Positive_regulation HAS1 IL1B 16258173 1489913 Two adenovirus constructs were used to further clarify differences in TGFbeta1- and *induced* [HAS1] activation . Positive_regulation HAS1 IL1B 16723203 1570380 EMSA data confirm that PDCT , at concentrations sufficient to completely block *induced* [HAS1] transcription , also entirely blocks IL-1beta induced NF-kappaB translocation . Positive_regulation HAS1 IL1B 16786194 1638493 *induced* [HAS] mRNA expression and HA production more efficiently than TNF-alpha and IFN-gamma . Positive_regulation HAS1 IL1B 17611197 1786713 stimulation *resulted* in induction of [HAS1] and HAS2 transcription but did not induce phenotypic differentiation or induce HA coat assembly . Positive_regulation HAS1 IL1B 18444484 1900656 and TNF-alpha *induced* each other and synergistically increased [HAS-1] and HAS-2 expression . Positive_regulation HAS1 IL1B 18444484 1900663 IFN-gamma , , TNF-alpha , and TGF-beta1 *up-regulated* [HAS] expression alongside either transient up-regulation of , or no change in , procollagen 1 and 3 expression . Positive_regulation HAS1 IL1B 20384487 2255764 slightly induced cAMP production , but *induced* [HAS] mRNA expression of all three isoforms and HA secretion . Positive_regulation HAS1 TNF 11389868 822413 These results suggest that and IL-1beta *regulate* [HAS] expression , and consequently may result in an accumulation of HA and an increase in HA of a lower molecular-weight . Positive_regulation HAS1 TNF 18444484 1900655 IL-1beta and *induced* each other and synergistically increased [HAS-1] and HAS-2 expression . Positive_regulation HAS1 TNF 18444484 1900662 IFN-gamma , IL-1beta , , and TGF-beta1 *up-regulated* [HAS] expression alongside either transient up-regulation of , or no change in , procollagen 1 and 3 expression . Positive_regulation HAS2 EPHB2 17493932 1761633 The activated then *increases* the phosphorylation of HAS1 , [HAS2] , and HAS3 . Positive_regulation HAS2 IL1B 10566653 567479 Expression of [hyaluronan synthase] messenger ribonucleic acids and their *induction* by in human orbital fibroblasts : potential insight into the molecular pathogenesis of thyroid associated ophthalmopathy . Positive_regulation HAS2 IL1B 15677552 1439200 Inhibitors of the p38 and ERK1/2 mitogen activated pathways but not JNK/SAPK blocked the *mediated* induction of hyaluronan expression and the increase in [HAS2] transcript expression . Positive_regulation HAS2 IL1B 15677552 1439202 These results suggest that *induction* of [HAS2] expression involves multiple signaling pathways that act in concert , thus leading to an increase in expression of hyaluronan by jejunum derived mesenchymal cells . Positive_regulation HAS2 IL1B 17611197 1786714 stimulation *resulted* in induction of HAS1 and [HAS2] transcription but did not induce phenotypic differentiation or induce HA coat assembly . Positive_regulation HAS2 IL1B 18158910 1869252 Antibody-neutralization study revealed that KGF and/or were at least *involved* in the up-regulation of HAS3 and [HAS2] expressions . Positive_regulation HAS2 IL1B 18444484 1900658 and TNF-alpha *induced* each other and synergistically increased HAS-1 and [HAS-2] expression . Positive_regulation HAS2 IL1B 19248106 2045039 *increased* HA production and levels of mRNA for HAS1 , [HAS2] , and HAS3 . Positive_regulation HAS2 TNF 18444484 1900657 IL-1beta and *induced* each other and synergistically increased HAS-1 and [HAS-2] expression . Positive_regulation HAS3 EGF 22493503 2607017 in turn *up-regulated* the expression of [HAS3] and versican V2 in dermal fibroblasts . Positive_regulation HAS3 EPHB2 17493932 1761634 The activated then *increases* the phosphorylation of HAS1 , HAS2 , and [HAS3] . Positive_regulation HAS3 FGF2 19577615 2129256 *induces* changes in [hyaluronan synthase] and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells . Positive_regulation HAS3 HAS2 23979132 2850550 Nevertheless , cholesterol-free oxLDL and unmodified cholesterol ( 20 µg/ml ) *induce* only [HAS3] transcription , whereas 22,oxysterol affects both and HAS3 . Positive_regulation HAS3 HBEGF 24658508 2942833 In contrast , [HAS3] can be *induced* by and seems mainly involved in AD epidermis . Positive_regulation HAS3 HGF 19507223 2098226 *induced* the upregulation of MMP-2 , -9 , and [HAS-3] , and downregulated the expression of procollagen type I. Histologically , aged vocal folds treated with HGF revealed decreased collagen deposition , and increased deposition of HA , compared to sham treated vocal folds . Positive_regulation HAS3 IL1B 10566653 567480 Expression of [hyaluronan synthase] messenger ribonucleic acids and their *induction* by in human orbital fibroblasts : potential insight into the molecular pathogenesis of thyroid associated ophthalmopathy . Positive_regulation HAS3 IL1B 18158910 1869253 Antibody-neutralization study revealed that KGF and/or were at least *involved* in the up-regulation of [HAS3] and HAS2 expressions . Positive_regulation HAS3 JAK2 12738686 1185275 Nonspecific inhibitors of HAS 3 ( cyclohexamide and dexamethasone ) , a nonspecific inhibitor of protein tyrosine kinases ( genistein ) , and a inhibitor ( AG490 ) *blocked* stretch induced [HAS 3] expression and synthesis of LMW HA . Positive_regulation HAS3 MAP2K1 17375476 1497187 In contrast , expression of , a constitutive form of MEK1 , *activated* both [hyaluronan synthase] expression and hyaluronan production . Positive_regulation HAS3 NAGLU 14976384 1213032 Conversely , *had* no effect on the expression of [HAS3] transcripts . Positive_regulation HAS3 TGFB1 20048602 2193572 Both Wnt3a and *induced* HAS2 and [HAS3] gene expression in embryonic fibroblasts , while HAS1 and Hyal2 were induced in postnatal fibroblasts . Positive_regulation HAS3 TNF 20443819 2009576 We determined that human intestinal endothelial cells generate HA in response to proinflammatory stimuli by demonstrating a *induced* increase in [hyaluronan synthase-3] mRNA expression and the accumulation of HA cable-like structures that are adhesive for leukocytes . Positive_regulation HAS3 WNT3A 20048602 2193573 Both and TGF-beta1 *induced* HAS2 and [HAS3] gene expression in embryonic fibroblasts , while HAS1 and Hyal2 were induced in postnatal fibroblasts . Positive_regulation HAVCR1 EPHB2 17898236 1802914 We found that constitutive cleavage of [KIM-1] is *mediated* by activation , and that cleavage is accelerated by p38 MAP kinase activation . Positive_regulation HAVCR2 MAP2K6 21621846 2470496 Similarly , MEK activation *enhanced* [TIM-3] transcription in TGF-ß stimulated HMC-1 human mast cells , although seemed not directly activated by TGF-ß . Positive_regulation HAVCR2 MAP2K6 21621846 2470503 Concordantly , -1.5kb [TIM-3] promoter activity was *reduced* by inhibitors , but was not responsive to TGF-ß stimulation in HMC-1 cells . Positive_regulation HAVCR2 MAP2K6 21621846 2470517 These results suggest the regulatory *role* of in [TIM-3] transcription by human CD4+ T cells and mast cells . Positive_regulation HAVCR2 TNF 23213314 2705636 [TIM-3] mRNA levels were *increased* in HMC-1 , a human mast cell line by TGF-ß1 stimulation but not by stimulation with interferon ( IFN ) -a , IFN-? , , or IL-10 . Positive_regulation HBA1 ARSA 16698007 1604754 induces a modest , not clinically relevant , *increase* in [HbA1c] levels with one of the methods . Positive_regulation HBA1 TNF 1341919 209346 However , serum levels progressively *increased* from the well to the poorly controlled diabetic groups : 8.1 +/- 1.5 ( G ) , 8.2 +/- 1.4 ( F ) and 9.4 +/- 2.4 ( P ) pg/ml , respectively , which parallel levels of [HbA1] ( % ) : 8.4 +/- 2.4 , 11.7 +/- 1.8 and 14.6 +/- 1.2 , respectively . Positive_regulation HBB TNF 8824249 384949 and PMA co-treatment of transfected cells *increases* [beta-globin-PAI-2] chimeric mRNA expression 3-4-fold , indicating that the inherently unstable 3'-UTR of PAI-2 mRNA can become stabilized in response to TNF and PMA . Positive_regulation HBD IL1B 10338476 615837 HBD-1 expression was constitutive , while [HBD-2] expression was *induced* by and LPS . Positive_regulation HBD IL1B 15240151 1270113 *Induction* of [human beta-defensin 2 (HBD-2)] by in epithelial cells has been reported . Positive_regulation HBD IL1B 15240151 1270115 markedly *increased* [HBD-2] mRNA expression in concentration- and time dependent manners . Positive_regulation HBD IL1B 15240151 1270122 Importantly , *induced* [HBD-2] mRNA expression was inhibited by blockage of NF-kappaB activation using NF-kappaB inhibitors , including pyrrolidine dithiocarbamate and MG132 . Positive_regulation HBD IL1B 15240151 1270135 Together , these results suggest that *induces* [HBD-2] mRNA expression in A549 cells , and the induction seems to be at least in part mediated through activation of NF-kappaB transcription factor as well as activation of signaling proteins of PKC , p38 MAPK , JNK , and PI3K , but not ERK . Positive_regulation HBD IL1B 17390080 1716121 We have previously demonstrated that *induced* [HBD-2] mRNA expression in A549 cells through activation of nuclear factor-kappaB (NF-kappaB) transcriptional factor as well as p38 mitogen activated protein kinase (MAPK) , c-Jun N-terminal kinase (JNK) , or phosphatidylinositol-3-kinase (PI3K) . Positive_regulation HBD IL1B 17390080 1716155 In this study , we investigated effects of triptolide on *induced* [HBD-2] mRNA expression in A549 cells . Positive_regulation HBD IL1B 17390080 1716156 Triptolide inhibited *induced* [HBD-2] mRNA expression in a dose dependent manner . Positive_regulation HBD IL1B 17390080 1716203 These results collectively suggest that the inhibitory effect of triptolide on *induced* [HBD-2] mRNA expression in A549 cells seems to be at least in part mediated through nuclear inhibition of NF-kappaB transcriptional activity , but not inhibition of p38 MAPK , JNK , or PI3K . Positive_regulation HBD IL1B 17645739 1793260 In this study , we further investigated whether dexamethasone ( Dex ) controls *induced* [HBD-2] mRNA expression in A549 cells and the molecular mechanism associated with it . Positive_regulation HBD IL1B 17645739 1793261 Dex suppressed *induced* [HBD-2] mRNA expression , which is mediated by a glucocorticoid receptor , at the transcriptional level . Positive_regulation HBD IL1B 17645739 1793282 These results suggest that Dex acts to inhibit *induced* [HBD-2] mRNA expression through blockage of the nuclear transcriptional activation of p65 NF-kappaB as well as through inactivation of p38 MAPK and JNK . Positive_regulation HBD IL1B 9843998 553700 The pro-inflammatory cytokine *stimulated* the expression of [HBD-2] but not HBD-1 mRNA and peptide in primary cultures of airway epithelia . Positive_regulation HBD SPHK1 20634980 2292173 Here we demonstrate that [HBD-2] induction is *mediated* by the and augmented by the inhibition of Glycogen Synthase Kinase-3beta ( GSK-3beta ) via the Phosphoinositide 3-kinase (PI3K) dependent pathway . Positive_regulation HBD SPHK1 20634980 2292174 [HBD-2] secretion was dose dependently *inhibited* by a pharmacological inhibitor of . Positive_regulation HBD TNF 17617590 1769645 This interferes with STAT-1 and NF-kappaB signaling , thereby inhibiting *mediated* induction of [HBD-2] and HBD-3 . Positive_regulation HBD TNF 18567888 1946413 Our results demonstrated that [HBD2] is *induced* by and RSV in an NF-kappaB dependent manner . Positive_regulation HBEGF ADAM17 20303353 2281698 Small interfering RNA mediated silencing of in AGS cells inhibited the repression of wild-type HKalpha promoter and *reduced* ADAM17 activity and [HB-EGF] production , compared to controls . Positive_regulation HBEGF ADAM17 21289053 2410030 Thus , HG-induced EGFR transactivation in MC is mediated by the release of [HB-EGF] , which *requires* activity of the metalloprotease . Positive_regulation HBEGF ADAM17 21386996 2400487 In agreement with previous studies , we demonstrated that PMA triggers a rapid *mediated* release of [HB-EGF] . Positive_regulation HBEGF ADAM17 21617117 2459144 We conclude that TNF transactivates ErbB4 through *dependent* [HB-EGF] release , thus protecting colon epithelial cells from cytokine induced apoptosis . Positive_regulation HBEGF ADAM17 23850346 2844284 Enzyme linked immunosorbent assay studies revealed that Nox4 and *mediated* the release of mature [heparin binding EGF-like growth factor] ( HB-EGF ) , which played a critical role in the Ang II-induced EGFR activation . Positive_regulation HBEGF ADAM17 23850346 2844287 it increased the expression of , which *induced* the release of mature [HB-EGF] . Positive_regulation HBEGF AKT1 15380451 1298458 [HB-EGF] *induced* phosphorylation of ERK , p38 MAPK and , which were suppressed by ZD1839 . Positive_regulation HBEGF AKT2 15380451 1298459 [HB-EGF] *induced* phosphorylation of ERK , p38 MAPK and , which were suppressed by ZD1839 . Positive_regulation HBEGF AKT3 15380451 1298460 [HB-EGF] *induced* phosphorylation of ERK , p38 MAPK and , which were suppressed by ZD1839 . Positive_regulation HBEGF ANGPT2 16554661 1574669 To determine if *dependent* [HB-EGF] release could act in a paracrine fashion on adjacent cells , HEK293 cells were stably transfected with green fluorescent protein tagged ERK2 ( GFP-ERK2 ) . Positive_regulation HBEGF ANGPT2 16554661 1574675 These data indicate that ERK activation is induced by ANG2 in podocytes by mechanisms involving *dependent* release of [HB-EGF] which , in turn , may act in an autocrine and paracrine fashion to stimulate ERK activity . Positive_regulation HBEGF ANGPT2 9814973 546387 We conclude that mechanical stretch activates [HB-EGF] gene expression in bladder SMC and that this is *mediated* in part by autocrine secretion . Positive_regulation HBEGF BCL2 20593979 2334415 Recombinant [HB-EGF] *induced* the , Bcl-xL mRNA/protein expression in HET-1A and TTn cells . Positive_regulation HBEGF CAMP 19797203 2224601 *induced* [HB-EGF-AP] release and EGFR activation in a dose dependent manner . Positive_regulation HBEGF CD44 16724877 1663370 and ( 4 ) retinaldehyde induced proliferative response of keratinocytes is a *dependent* phenomenon and requires the presence of [HB-EGF] , erbB1 and matrix metalloproteinases . Positive_regulation HBEGF CD44 21179550 2358302 Our results indicate that ( i ) RAL induced in vitro and in vivo keratinocyte proliferation is a *dependent* phenomenon and requires the presence of HA , [HB-EGF] , erbB1 and MMPs , ( ii ) RAL and HAFi show a synergy in vitro and in vivo in mouse skin , and ( iii ) the combination of RAL and HAFi seems to have an important therapeutic effect in dermatoporosis . Positive_regulation HBEGF CD69 20739460 2324357 Analysis of the events occurring in neutrophil/NK co-cultures exposed to IL-15 plus IL-18 revealed that (i) neutrophil survival is positively affected by NK-derived GM-CSF but negatively influenced by a CD18 dependent neutrophil/NK contact , ( ii ) NK-derived IFN? is almost entirely responsible for the induction of CD64 , ( iii ) both soluble factors ( primarily GM-CSF ) and direct cell-cell contact up-regulate CD11b and and ( iv ) NK-derived GM-CSF *induces* the expression of biologically active [heparin binding EGF-like growth factor] ( HB-EGF ) in neutrophils . Positive_regulation HBEGF CD9 11735113 885692 Human and monkey *upregulates* DT binding activity of [DTR] , while mouse CD9 has no upregulation activity . Positive_regulation HBEGF CD9 9396739 468834 HB-EGF and at both the mRNA and the protein level were up-regulated after differentiation into macrophages , and further expression of [HB-EGF] was *induced* by the addition of OxLDL or lysophosphatidylcholine . Positive_regulation HBEGF CD9 9514697 477354 Functional analysis of four tetraspans , CD9 , CD53 , CD81 , and CD82 , suggests a common role in costimulation , cell adhesion , and migration : only *upregulates* [HB-EGF] activity . Positive_regulation HBEGF CDC73 17322418 1747801 Increased alkaline phosphatase ( AP ) activity after PAF treatment in AP-HB-EGF fusion construct transfected SMCs indicated that *induced* the release of [HB-EGF] within 1 min. Gelatin zymography data showed that PAF stimulated MMP-2 activity and MMP-9 activity within 1 min . Positive_regulation HBEGF CDC73 7713868 298110 These results suggest a potential *role* of in [HB-EGF] expression and provide evidence that this stimulation may occur through increased kappa B binding activity . Positive_regulation HBEGF CDX2 12223343 987728 These data indicate that [HB-EGF] gene expression can be *regulated* by and serves to mediate the control of Cdx2 of the proliferation and migration of IEC-6 cells . Positive_regulation HBEGF CSF2 10556204 565894 Thus , we provide evidence that [HB-EGF] is specifically *inducible* by in PMN and represents a novel peptide to be included in the repertoire of PMN derived cytokines . Positive_regulation HBEGF CSF2 20739460 2324358 Analysis of the events occurring in neutrophil/NK co-cultures exposed to IL-15 plus IL-18 revealed that (i) neutrophil survival is positively affected by NK-derived GM-CSF but negatively influenced by a CD18 dependent neutrophil/NK contact , ( ii ) NK-derived IFN? is almost entirely responsible for the induction of CD64 , ( iii ) both soluble factors ( primarily GM-CSF ) and direct cell-cell contact up-regulate CD11b and CD69 and ( iv ) NK-derived *induces* the expression of biologically active heparin binding EGF-like growth factor ( [HB-EGF] ) in neutrophils . Positive_regulation HBEGF CTR9 17322418 1747802 Increased alkaline phosphatase ( AP ) activity after PAF treatment in AP-HB-EGF fusion construct transfected SMCs indicated that *induced* the release of [HB-EGF] within 1 min. Gelatin zymography data showed that PAF stimulated MMP-2 activity and MMP-9 activity within 1 min . Positive_regulation HBEGF CTR9 7713868 298111 These results suggest a potential *role* of in [HB-EGF] expression and provide evidence that this stimulation may occur through increased kappa B binding activity . Positive_regulation HBEGF ECM1 10210777 607662 We investigated whether the interaction of human monocytic THP-1 cells with the endothelial cell adhesion molecules ( vascular CAM-1 , VCAM-1 ; intercellular adhesion molecule-1 ICAM-1 and endothelial-selectin , E-selectin ) , or the proteins ( fibronectin , FN ; laminin , LN and fibrinogen , FG ) *regulate* [HB-EGF] expression . Positive_regulation HBEGF ECM2 10210777 607663 We investigated whether the interaction of human monocytic THP-1 cells with the endothelial cell adhesion molecules ( vascular CAM-1 , VCAM-1 ; intercellular adhesion molecule-1 ICAM-1 and endothelial-selectin , E-selectin ) , or the proteins ( fibronectin , FN ; laminin , LN and fibrinogen , FG ) *regulate* [HB-EGF] expression . Positive_regulation HBEGF EDN1 12853287 1149768 Consistent with the gene expression profile , quantitative RT-PCR and Western blotting confirmed *induction* of [HB-EGF] by . Positive_regulation HBEGF EGF 10425274 632814 These results indicate that EGF and [HB-EGF] possess different functions in RGM-1 cells and that *acts* as a mediator of both cell maturation and apoptosis in these cells . Positive_regulation HBEGF EGF 10548517 564909 stimulation *increased* transcription of TGF-alpha , AR , and [HB-EGF] by 3- to 4-fold within 1 to 2 h . Positive_regulation HBEGF EGF 11208719 787286 We determined the *role* of in stress induced expression of heparin binding EGF-like growth factor ( [HB-EGF] ) in a rat gastric epithelial cell line ( RGM1 cells ) . Positive_regulation HBEGF EGF 12791271 1097679 Lack of c-Jun prevents *induced* expression of [HB-EGF] , indicating that c-jun controls formation of the epidermal leading edge through its control of an EGF receptor autocrine loop . Positive_regulation HBEGF EGF 15887238 1445522 Induction of [heparin binding EGF-like growth factor] and *activation* of receptor in imatinib mesylate treated squamous carcinoma cells . Positive_regulation HBEGF EGF 18092233 1834956 Importantly , [HB-EGF-and] *induced* tube formation was comparable to , but were independent of tube formation induced by VEGF . Positive_regulation HBEGF EGF 24188029 2921063 Here , we show that [HB-EGF] *induced* activation by Y1068 phosphorylation , Mapk/Erk pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation HBEGF EGF 9541490 498070 Inhibition of AR- or [HB-EGF-] induced stimulation of cell growth was not *mediated* by downregulation of the receptor since EGF receptor protein levels , EGF binding affinity , number of specific binding sites for EGF , or HB-EGF- or AR-dependent tyrosine phosphorylation of the EGF receptor were not significantly altered by incubation with H. pylori broth culture filtrates . Positive_regulation HBEGF EGFR 15277479 1277206 Bacterial infection of HCECs *induces* transactivation through [HB-EGF] ectodomain shedding . Positive_regulation HBEGF EGFR 15557365 1343395 These novel findings suggest that the mechanism of pressure induced MT involves metalloproteinases 2/9 activation with subsequent [HB-EGF] release and *transactivation* . Positive_regulation HBEGF EGFR 16641152 1563000 In summary , this is the first demonstration that [HB-EGF] shedding dependent *transactivation* , along with activation of TGF-beta signaling pathways , mediates Ang II-induced renal tubular epithelial cell hypertrophy . Positive_regulation HBEGF EGFR 17284517 1698254 Taken together , our data suggest that ATP , released upon epithelial injury , acts as an early signal to trigger cell responses including an increase in [HB-EGF] shedding , subsequent *transactivation* and its downstream signaling , resulting in wound healing . Positive_regulation HBEGF EGFR 17360433 1712706 HT-H cells expressed ErbB family receptors and bound EGF and [heparin binding EGF-like growth factor] ( HB-EGF ) , but family receptor phosphorylation in these cells *required* GWRQ . Positive_regulation HBEGF EGFR 17395697 1748534 Although [HB-EGF] expression is mainly restricted to the oocytes , its expression in cultured granulosa cells could be transiently yet strongly *induced* by HB-EGF and other ligands including EGF and TGF-alpha . Positive_regulation HBEGF EGFR 17717322 1848769 Our data , for the first time , showed that IL-13 plays an important role in epithelial repair , and that its effect is mediated through the autocrine release of [HB-EGF] and *activation* of . Positive_regulation HBEGF EGFR 17848576 1817808 Juxtacrine *activation* of by membrane anchored [heparin binding EGF-like growth factor] protects epithelial cells from anoikis while maintaining an epithelial phenotype . Positive_regulation HBEGF EGFR 17855771 1818203 Therefore , we hypothesize that juxtacrine *activation* of by membrane anchored [HB-EGF] may play an important role in the regulation of tight junction proteins and TER . Positive_regulation HBEGF EGFR 18658095 2011014 Taken together , our data suggest that in addition to functioning as an EGFR downstream effector , ERK1/2 also mediates ADAM dependent [HB-EGF] shedding and subsequent *transactivation* in response to a variety of stimuli , including wounding and GPCR ligands . Positive_regulation HBEGF EGFR 18986098 1983743 The authors conclude that leptin stimulates OAC proliferation via increased gene expression of HB-EGF and TGFalpha , MMP mediated extracellular release of [HB-EGF] and TGFalpha and subsequent *activation* of . Positive_regulation HBEGF EGFR 19225541 2100065 In summary , rapid HA accumulation after epidermal wounding occurs through a mechanism requiring cleavage of [HB-EGF] and *activation* of signaling . Positive_regulation HBEGF EGFR 19797203 2224600 Heparin binding EGF-like growth factor ( HB-EGF ) shedding was assessed by measuring the release of alkaline phosphatase ( AP ) in a stable HCEC line expressing [HB-EGF-AP.] *Activation* of , phosphoinositide 3-kinase (PI3K) , and extracellular signal regulated kinases 1/2 ( ERK1/2 ) was determined by Western blot analysis . Positive_regulation HBEGF EGFR 19879874 2197167 This study demonstrates a novel role of TK in skin wound healing and uncovers new signaling pathways mediated by TK in promoting keratinocyte migration through activation of the PAR(1)-PKC-Src-MMP pathway and [HB-EGF/AR] shedding dependent *transactivation* . Positive_regulation HBEGF EGFR 20208558 2259488 Activation of by proteasome inhibition *requires* [HB-EGF] in pancreatic cancer cells . Positive_regulation HBEGF EGFR 20934403 2347603 [HB-EGF-CTF] nuclear translocation and *transactivation* from proHB-EGF shedding mediated by ADAM17 activated by TGFß might be an important pathway of gastric cancer cell proliferation by TGFß . Positive_regulation HBEGF EGFR 21552904 345724 It ( a ) blocks the binding of EGF , TGF alpha and HB-EGF to the EGFR , ( b ) prevents the EGF , TGF alpha and [HB-EGF] *induced* tyrosine phosphorylation of the , and ( c ) inhibits the growth in vitro of the head and neck tumour ( HN5 ) cell line overexpressing the EGF receptor . Positive_regulation HBEGF EGR1 20190820 2248829 *increased* the transcription of [HB-EGF] ( epidermal growth factor ) , amphiregulin and epiregulin , resulting in autocrine activation of the EGF receptor (EGFR) and downstream MEK/ERK cascade . Positive_regulation HBEGF EPHB2 16799022 1579185 PP2 at a concentration as high as 50 microM exhibited no effects on [HB-EGF] *induced* phosphorylation . Positive_regulation HBEGF EPHB2 18990151 2028905 *Activation* of by [HB-EGF] was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation HBEGF EPHB2 20208558 2259492 Furthermore , we discover that induction of [HB-EGF] is *dependent* on reactive oxygen species and p38-MAPK signaling but not and that the transcription factor SP-1 is involved in NPI-0052 induced HB-EGF transcription . Positive_regulation HBEGF EPHB2 24188029 2921064 Here , we show that [HB-EGF] *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation HBEGF EREG 10681561 669412 *up-regulated* the mRNA levels of [heparin binding EGF-like growth factor] ( HB-EGF ) , amphiregulin , and TGF-alpha . Positive_regulation HBEGF EREG 18079685 1834433 *increased* the expression of [HB-EGF] and AR , while TGF-alpha , HB-EGF , AR , and EGF increased the expression of epiregulin in HCECs . Positive_regulation HBEGF F2RL1 21788507 2467523 We show that PAR-2 dependent HB-EGF induction was associated with increased phosphorylation of ERK1/2 , and inhibition of ERK1/2 phosphorylation attenuated *dependent* [HB-EGF] induction as well as EC activation . Positive_regulation HBEGF FGF2 10579352 569834 Expression of both ARG and [HB-EGF] mRNAs was *induced* in cultured prostate SMC by , a human prostate SMC mitogen linked to prostate disease . Positive_regulation HBEGF FGF2 9796995 543505 When added to the medium , transforming growth factor-alpha , , or HB-EGF rapidly *induced* [HB-EGF] mRNA expression . Positive_regulation HBEGF FN1 10210777 607671 Thus physiologically , transient destruction of LN and expression of VCAM-1 , E-selectin and at sites of inflammation , may locally *induce* [HB-EGF] overexpression . Positive_regulation HBEGF GAST 10759214 683094 Reg protein production by ECL cells , as well as [HB-EGF] and AR production by parietal cells , is *stimulated* by and these growth factors are potent trophic agents of progenitor cells in the neck zone of the gastric fundic mucosa . Positive_regulation HBEGF GAST 12388195 1012729 dose-dependently *increased* [HB-EGF] , COX-2 expression , and PGE ( 2 ) levels and reduced gastric damage . Positive_regulation HBEGF GAST 14764442 1242869 stimulation *resulted* in a fivefold increase in [HB-EGF-luciferase] activity . Positive_regulation HBEGF GAST 9869605 583149 *induced* expression of HB-EGF mRNA , processing of proHB-EGF , release of [HB-EGF] into the medium , and tyrosine phosphorylation of the EGF receptor . Positive_regulation HBEGF GRAP2 20208558 2259493 Furthermore , we discover that induction of [HB-EGF] is *dependent* on reactive oxygen species and signaling but not ERK and that the transcription factor SP-1 is involved in NPI-0052 induced HB-EGF transcription . Positive_regulation HBEGF HAS3 24658508 2942832 In contrast , can be *induced* by [HB-EGF] and seems mainly involved in AD epidermis . Positive_regulation HBEGF HSPG2 20117092 2219721 Galphaq was found to *mediate* the UVB induced [HB-EGF] secretion by sequential activation of , protein kinase Cdelta (PKCdelta) , and matrix metaloprotease-2 (MMP-2) . Positive_regulation HBEGF IGF1 8617994 353957 at 100 ng/ml , *increased* [HB-EGF] mitogenic activity for Balb/MK keratinocytes by 40-50 fold . Positive_regulation HBEGF IL13 17717322 1848765 Interestingly , we found that *induces* [HB-EGF] , but not EGF , synthesis and release from AEC . Positive_regulation HBEGF IL17A 16311048 1553748 in OA and RA , also *increased* the [HB-EGF] secretion and the expression of TIMP-1 as protein and mRNA . Positive_regulation HBEGF IL17A 20530256 2284563 These observations demonstrated that overexpression of airway [HB-EGF] *induced* by secreted from redundant expanding Th17 cells might contribute to excessive mucus expression and ASM proliferation in chronic asthma . Positive_regulation HBEGF IL1A 22911722 2648573 These results suggest that contact with fibroblasts stimulates the migration and proliferation of keratinocytes during wound healing , and that [HB-EGF] plays a central role in this process and can be *up-regulated* by and TGF-ß1 , which also regulate keratinocyte proliferation differently during the early and late stage . Positive_regulation HBEGF IL1B 1577791 187539 However , tumor necrosis factor-alpha (TNF-alpha) and markedly *increased* [HB-EGF] mRNA levels in HUVEC by 12- and 7-fold , respectively , and induction of the gene by TNF-alpha was both dose- and time dependent . Positive_regulation HBEGF IL2 9130444 426858 Lyso-PC induced upregulation of [HB-EGF] and IL-2 receptor mRNA in peripheral T cells is mostly *dependent* on exogenous in conditioned medium . Positive_regulation HBEGF IL8 20588025 2285740 Here , we focus on the mechanisms of *induced* [HB-EGF-CTF] signaling , which is involved in cytoprotection and cellular repair . Positive_regulation HBEGF INS 17274952 1697426 *induces* a transcriptional activation of epiregulin , [HB-EGF] and amphiregulin , by a PI3K dependent mechanism : identification of a specific insulin-responsive promoter element . Positive_regulation HBEGF INS 17274952 1697433 We demonstrate that the *induced* expression of [HB-EGF] , AR , and EPI mRNA is completely prevented by the specific PI3K inhibitor Wortmannin , suggesting an involvement of the PI3K . Positive_regulation HBEGF ITGAM 20739460 2324359 Analysis of the events occurring in neutrophil/NK co-cultures exposed to IL-15 plus IL-18 revealed that (i) neutrophil survival is positively affected by NK-derived GM-CSF but negatively influenced by a CD18 dependent neutrophil/NK contact , ( ii ) NK-derived IFN? is almost entirely responsible for the induction of CD64 , ( iii ) both soluble factors ( primarily GM-CSF ) and direct cell-cell contact up-regulate and CD69 and ( iv ) NK-derived GM-CSF *induces* the expression of biologically active heparin binding EGF-like growth factor ( [HB-EGF] ) in neutrophils . Positive_regulation HBEGF JUN 10318950 611996 In this system , induction of is *followed* within 1 hr by elevated levels of [HB-EGF] . Positive_regulation HBEGF JUN 12791272 1097680 Thus , using three experimental systems , we show that EGFR and [HB-EGF] are *regulated* by , which controls eyelid development , keratinocyte proliferation , and skin tumor formation . Positive_regulation HBEGF JUN 17001310 1716320 Using RNA interference , we demonstrated that the chemotherapy induced [HB-EGF] was largely *dependent* on and NF-kappaB activation . Positive_regulation HBEGF LEO1 17322418 1747805 Increased alkaline phosphatase ( AP ) activity after PAF treatment in AP-HB-EGF fusion construct transfected SMCs indicated that *induced* the release of [HB-EGF] within 1 min. Gelatin zymography data showed that PAF stimulated MMP-2 activity and MMP-9 activity within 1 min . Positive_regulation HBEGF LEO1 7713868 298114 These results suggest a potential *role* of in [HB-EGF] expression and provide evidence that this stimulation may occur through increased kappa B binding activity . Positive_regulation HBEGF LEP 18986098 1983696 significantly *increased* gene expression of [HB-EGF] and TGFalpha as measured by a quantitative real-time polymerase chain reaction ( PCR ) method but did not alter amphiregulin and EGFR gene expression . Positive_regulation HBEGF LEP 18986098 1983702 *increased* extracellular release of [HB-EGF] and TGFalpha and this was blocked by matrix metalloproteinase (MMP) inhibitors . Positive_regulation HBEGF LPA 10354366 617775 and S1P *increased* the Tsup-1 cell level of immunoreactive [HB-EGF] , and neutralizing antibodies to HB-EGF inhibited LPA and S1P enhancement of Tsup-1 cell susceptibility to DT . Positive_regulation HBEGF LPA 10354366 617784 Similar transfection with Edg-3 plus -5 antisense plasmids suppressed Tsup-1 cell levels of immunoreactive Edg-3 and -5 , but not Edg-2 or -4 , and concurrently reduced S1P- , but not , induced Tsup-1 cell *increases* in both [HB-EGF] and susceptibility to DT . Positive_regulation HBEGF LPA 15149861 1248433 We established that mouse blastocysts indeed express [HB-EGF] and that *induces* the transient accumulation of HB-EGF on the embryo surface , which was blocked by treatment with either BAPTA-AM or the protein trafficking inhibitor , brefeldin A . Positive_regulation HBEGF LPA 15313912 1285687 , which is constitutively produced by ovarian cancer cells , *induced* [HB-EGF] ectodomain shedding in SKOV3 and RMG-1 cells , resulting in the transactivation of EGFR and the downstream kinase extracellular signal regulated kinase/mitogen activated protein kinase . Positive_regulation HBEGF LPA 17251460 1690995 The release of HB-EGF assessed by AP activity increased significantly in response to wounding , LPA , or both , and the release of [HB-EGF-AP] *induced* by was inhibited by PP2 and GM6001 . Positive_regulation HBEGF LPAR1 10354366 617781 Similar transfection with Edg-3 plus -5 antisense plasmids suppressed Tsup-1 cell levels of immunoreactive Edg-3 and -5 , but not or -4 , and concurrently reduced S1P- , but not LPA- , *induced* Tsup-1 cell increases in both [HB-EGF] and susceptibility to DT . Positive_regulation HBEGF MAPK1 11171084 783778 Both p42 activation and [HB-EGF] mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation HBEGF MAPK1 15380451 1298461 [HB-EGF] *induced* phosphorylation of ERK , p38 and Akt , which were suppressed by ZD1839 . Positive_regulation HBEGF MAPK1 18990151 2028906 *Activation* of by [HB-EGF] was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation HBEGF MAPK1 20208558 2259494 Furthermore , we discover that induction of [HB-EGF] is *dependent* on reactive oxygen species and signaling but not ERK and that the transcription factor SP-1 is involved in NPI-0052 induced HB-EGF transcription . Positive_regulation HBEGF MAPK1 20739666 2345873 Moreover , [HBEGF] *induced* a stronger and more sustained activation of both the and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation HBEGF MAPK1 23517395 2761738 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Positive_regulation HBEGF MAPK1 24188029 2921065 Here , we show that [HB-EGF] *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation HBEGF MAPK10 11171084 783779 Both p42 activation and [HB-EGF] mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation HBEGF MAPK10 15380451 1298462 [HB-EGF] *induced* phosphorylation of ERK , p38 and Akt , which were suppressed by ZD1839 . Positive_regulation HBEGF MAPK10 18990151 2028907 *Activation* of by [HB-EGF] was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation HBEGF MAPK10 20208558 2259495 Furthermore , we discover that induction of [HB-EGF] is *dependent* on reactive oxygen species and signaling but not ERK and that the transcription factor SP-1 is involved in NPI-0052 induced HB-EGF transcription . Positive_regulation HBEGF MAPK10 20739666 2345874 Moreover , [HBEGF] *induced* a stronger and more sustained activation of both the and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation HBEGF MAPK10 23517395 2761739 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Positive_regulation HBEGF MAPK10 24188029 2921066 Here , we show that [HB-EGF] *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation HBEGF MAPK11 11171084 783780 Both p42 activation and [HB-EGF] mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation HBEGF MAPK11 15380451 1298463 [HB-EGF] *induced* phosphorylation of ERK , p38 and Akt , which were suppressed by ZD1839 . Positive_regulation HBEGF MAPK11 18990151 2028908 *Activation* of by [HB-EGF] was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation HBEGF MAPK11 20208558 2259496 Furthermore , we discover that induction of [HB-EGF] is *dependent* on reactive oxygen species and signaling but not ERK and that the transcription factor SP-1 is involved in NPI-0052 induced HB-EGF transcription . Positive_regulation HBEGF MAPK11 20739666 2345875 Moreover , [HBEGF] *induced* a stronger and more sustained activation of both the and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation HBEGF MAPK11 23517395 2761740 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Positive_regulation HBEGF MAPK11 24188029 2921067 Here , we show that [HB-EGF] *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation HBEGF MAPK12 11171084 783781 Both p42 activation and [HB-EGF] mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation HBEGF MAPK12 15380451 1298464 [HB-EGF] *induced* phosphorylation of ERK , p38 and Akt , which were suppressed by ZD1839 . Positive_regulation HBEGF MAPK12 18990151 2028909 *Activation* of by [HB-EGF] was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation HBEGF MAPK12 20208558 2259497 Furthermore , we discover that induction of [HB-EGF] is *dependent* on reactive oxygen species and signaling but not ERK and that the transcription factor SP-1 is involved in NPI-0052 induced HB-EGF transcription . Positive_regulation HBEGF MAPK12 20739666 2345876 Moreover , [HBEGF] *induced* a stronger and more sustained activation of both the and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation HBEGF MAPK12 23517395 2761741 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Positive_regulation HBEGF MAPK12 24188029 2921068 Here , we show that [HB-EGF] *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation HBEGF MAPK13 11171084 783782 Both p42 activation and [HB-EGF] mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation HBEGF MAPK13 15380451 1298465 [HB-EGF] *induced* phosphorylation of ERK , p38 and Akt , which were suppressed by ZD1839 . Positive_regulation HBEGF MAPK13 18990151 2028910 *Activation* of by [HB-EGF] was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation HBEGF MAPK13 20208558 2259498 Furthermore , we discover that induction of [HB-EGF] is *dependent* on reactive oxygen species and signaling but not ERK and that the transcription factor SP-1 is involved in NPI-0052 induced HB-EGF transcription . Positive_regulation HBEGF MAPK13 20739666 2345877 Moreover , [HBEGF] *induced* a stronger and more sustained activation of both the and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation HBEGF MAPK13 23517395 2761742 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Positive_regulation HBEGF MAPK13 24188029 2921069 Here , we show that [HB-EGF] *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation HBEGF MAPK14 11171084 783783 Both p42 activation and [HB-EGF] mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation HBEGF MAPK14 15380451 1298466 [HB-EGF] *induced* phosphorylation of ERK , p38 and Akt , which were suppressed by ZD1839 . Positive_regulation HBEGF MAPK14 18990151 2028911 *Activation* of by [HB-EGF] was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation HBEGF MAPK14 20208558 2259499 Furthermore , we discover that induction of [HB-EGF] is *dependent* on reactive oxygen species and signaling but not ERK and that the transcription factor SP-1 is involved in NPI-0052 induced HB-EGF transcription . Positive_regulation HBEGF MAPK14 20739666 2345878 Moreover , [HBEGF] *induced* a stronger and more sustained activation of both the and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation HBEGF MAPK14 23517395 2761743 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Positive_regulation HBEGF MAPK14 24188029 2921070 Here , we show that [HB-EGF] *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation HBEGF MAPK15 11171084 783777 Both p42 activation and [HB-EGF] mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation HBEGF MAPK15 15380451 1298457 [HB-EGF] *induced* phosphorylation of ERK , p38 and Akt , which were suppressed by ZD1839 . Positive_regulation HBEGF MAPK15 18990151 2028904 *Activation* of by [HB-EGF] was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation HBEGF MAPK15 20208558 2259491 Furthermore , we discover that induction of [HB-EGF] is *dependent* on reactive oxygen species and signaling but not ERK and that the transcription factor SP-1 is involved in NPI-0052 induced HB-EGF transcription . Positive_regulation HBEGF MAPK15 20739666 2345872 Moreover , [HBEGF] *induced* a stronger and more sustained activation of both the and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation HBEGF MAPK15 23517395 2761737 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Positive_regulation HBEGF MAPK15 24188029 2921062 Here , we show that [HB-EGF] *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation HBEGF MAPK3 11171084 783784 Both p42 activation and [HB-EGF] mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation HBEGF MAPK3 15380451 1298467 [HB-EGF] *induced* phosphorylation of ERK , p38 and Akt , which were suppressed by ZD1839 . Positive_regulation HBEGF MAPK3 17761534 1807946 [HB-EGF] also *induced* early activation of in JM-a/CYT-2 cells and promoted nuclear translocation of the JM-a/CYT-2 cytoplasmic tail . Positive_regulation HBEGF MAPK3 18990151 2028912 *Activation* of by [HB-EGF] was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation HBEGF MAPK3 20208558 2259500 Furthermore , we discover that induction of [HB-EGF] is *dependent* on reactive oxygen species and signaling but not ERK and that the transcription factor SP-1 is involved in NPI-0052 induced HB-EGF transcription . Positive_regulation HBEGF MAPK3 20739666 2345879 Moreover , [HBEGF] *induced* a stronger and more sustained activation of both the and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation HBEGF MAPK3 21788507 2467524 We show that PAR-2 dependent [HB-EGF] induction was associated with increased phosphorylation of ERK1/2 , and inhibition of phosphorylation *attenuated* PAR-2 dependent HB-EGF induction as well as EC activation . Positive_regulation HBEGF MAPK3 23517395 2761744 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Positive_regulation HBEGF MAPK3 24188029 2921071 Here , we show that [HB-EGF] *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation HBEGF MAPK4 11171084 783785 Both p42 activation and [HB-EGF] mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation HBEGF MAPK4 15380451 1298468 [HB-EGF] *induced* phosphorylation of ERK , p38 and Akt , which were suppressed by ZD1839 . Positive_regulation HBEGF MAPK4 18990151 2028913 *Activation* of by [HB-EGF] was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation HBEGF MAPK4 20208558 2259501 Furthermore , we discover that induction of [HB-EGF] is *dependent* on reactive oxygen species and signaling but not ERK and that the transcription factor SP-1 is involved in NPI-0052 induced HB-EGF transcription . Positive_regulation HBEGF MAPK4 20739666 2345880 Moreover , [HBEGF] *induced* a stronger and more sustained activation of both the and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation HBEGF MAPK4 23517395 2761745 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Positive_regulation HBEGF MAPK4 24188029 2921072 Here , we show that [HB-EGF] *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation HBEGF MAPK6 11171084 783786 Both p42 activation and [HB-EGF] mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation HBEGF MAPK6 15380451 1298469 [HB-EGF] *induced* phosphorylation of ERK , p38 and Akt , which were suppressed by ZD1839 . Positive_regulation HBEGF MAPK6 18990151 2028914 *Activation* of by [HB-EGF] was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation HBEGF MAPK6 20208558 2259502 Furthermore , we discover that induction of [HB-EGF] is *dependent* on reactive oxygen species and signaling but not ERK and that the transcription factor SP-1 is involved in NPI-0052 induced HB-EGF transcription . Positive_regulation HBEGF MAPK6 20739666 2345881 Moreover , [HBEGF] *induced* a stronger and more sustained activation of both the and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation HBEGF MAPK6 23517395 2761746 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Positive_regulation HBEGF MAPK6 24188029 2921073 Here , we show that [HB-EGF] *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation HBEGF MAPK7 11171084 783787 Both p42 activation and [HB-EGF] mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation HBEGF MAPK7 15380451 1298470 [HB-EGF] *induced* phosphorylation of ERK , p38 and Akt , which were suppressed by ZD1839 . Positive_regulation HBEGF MAPK7 18990151 2028915 *Activation* of by [HB-EGF] was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation HBEGF MAPK7 20208558 2259503 Furthermore , we discover that induction of [HB-EGF] is *dependent* on reactive oxygen species and signaling but not ERK and that the transcription factor SP-1 is involved in NPI-0052 induced HB-EGF transcription . Positive_regulation HBEGF MAPK7 20739666 2345882 Moreover , [HBEGF] *induced* a stronger and more sustained activation of both the and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation HBEGF MAPK7 23517395 2761747 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Positive_regulation HBEGF MAPK7 24188029 2921074 Here , we show that [HB-EGF] *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation HBEGF MAPK8 11171084 783788 Both p42 activation and [HB-EGF] mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation HBEGF MAPK8 15380451 1298471 [HB-EGF] *induced* phosphorylation of ERK , p38 and Akt , which were suppressed by ZD1839 . Positive_regulation HBEGF MAPK8 18990151 2028916 *Activation* of by [HB-EGF] was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation HBEGF MAPK8 20208558 2259504 Furthermore , we discover that induction of [HB-EGF] is *dependent* on reactive oxygen species and signaling but not ERK and that the transcription factor SP-1 is involved in NPI-0052 induced HB-EGF transcription . Positive_regulation HBEGF MAPK8 20739666 2345883 Moreover , [HBEGF] *induced* a stronger and more sustained activation of both the and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation HBEGF MAPK8 23517395 2761748 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Positive_regulation HBEGF MAPK8 24188029 2921075 Here , we show that [HB-EGF] *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation HBEGF MAPK9 11171084 783789 Both p42 activation and [HB-EGF] mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation HBEGF MAPK9 15380451 1298472 [HB-EGF] *induced* phosphorylation of ERK , p38 and Akt , which were suppressed by ZD1839 . Positive_regulation HBEGF MAPK9 18990151 2028917 *Activation* of by [HB-EGF] was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation HBEGF MAPK9 20208558 2259505 Furthermore , we discover that induction of [HB-EGF] is *dependent* on reactive oxygen species and signaling but not ERK and that the transcription factor SP-1 is involved in NPI-0052 induced HB-EGF transcription . Positive_regulation HBEGF MAPK9 20739666 2345884 Moreover , [HBEGF] *induced* a stronger and more sustained activation of both the and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation HBEGF MAPK9 23517395 2761749 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Positive_regulation HBEGF MAPK9 24188029 2921076 Here , we show that [HB-EGF] *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation HBEGF MBTPS1 10354366 617774 LPA and *increased* the Tsup-1 cell level of immunoreactive [HB-EGF] , and neutralizing antibodies to HB-EGF inhibited LPA and S1P enhancement of Tsup-1 cell susceptibility to DT . Positive_regulation HBEGF MBTPS1 10354366 617780 Similar transfection with Edg-3 plus -5 antisense plasmids suppressed Tsup-1 cell levels of immunoreactive Edg-3 and -5 , but not Edg-2 or -4 , and concurrently reduced , but not LPA- , *induced* Tsup-1 cell increases in both [HB-EGF] and susceptibility to DT . Positive_regulation HBEGF MMP1 15143154 1273167 These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of *dependent* [HB-EGF] release . Positive_regulation HBEGF MMP1 18986098 1983703 Leptin increased extracellular release of [HB-EGF] and TGFalpha and this was *blocked* by inhibitors . Positive_regulation HBEGF MMP10 15143154 1273168 These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of *dependent* [HB-EGF] release . Positive_regulation HBEGF MMP10 18986098 1983704 Leptin increased extracellular release of [HB-EGF] and TGFalpha and this was *blocked* by inhibitors . Positive_regulation HBEGF MMP11 15143154 1273169 These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of *dependent* [HB-EGF] release . Positive_regulation HBEGF MMP11 18986098 1983705 Leptin increased extracellular release of [HB-EGF] and TGFalpha and this was *blocked* by inhibitors . Positive_regulation HBEGF MMP12 15143154 1273170 These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of *dependent* [HB-EGF] release . Positive_regulation HBEGF MMP12 18986098 1983706 Leptin increased extracellular release of [HB-EGF] and TGFalpha and this was *blocked* by inhibitors . Positive_regulation HBEGF MMP13 15143154 1273171 These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of *dependent* [HB-EGF] release . Positive_regulation HBEGF MMP13 18986098 1983707 Leptin increased extracellular release of [HB-EGF] and TGFalpha and this was *blocked* by inhibitors . Positive_regulation HBEGF MMP14 15143154 1273172 These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of *dependent* [HB-EGF] release . Positive_regulation HBEGF MMP14 18986098 1983708 Leptin increased extracellular release of [HB-EGF] and TGFalpha and this was *blocked* by inhibitors . Positive_regulation HBEGF MMP15 15143154 1273173 These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of *dependent* [HB-EGF] release . Positive_regulation HBEGF MMP15 18986098 1983709 Leptin increased extracellular release of [HB-EGF] and TGFalpha and this was *blocked* by inhibitors . Positive_regulation HBEGF MMP16 15143154 1273174 These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of *dependent* [HB-EGF] release . Positive_regulation HBEGF MMP16 18986098 1983710 Leptin increased extracellular release of [HB-EGF] and TGFalpha and this was *blocked* by inhibitors . Positive_regulation HBEGF MMP17 15143154 1273175 These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of *dependent* [HB-EGF] release . Positive_regulation HBEGF MMP17 18986098 1983711 Leptin increased extracellular release of [HB-EGF] and TGFalpha and this was *blocked* by inhibitors . Positive_regulation HBEGF MMP19 15143154 1273176 These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of *dependent* [HB-EGF] release . Positive_regulation HBEGF MMP19 18986098 1983712 Leptin increased extracellular release of [HB-EGF] and TGFalpha and this was *blocked* by inhibitors . Positive_regulation HBEGF MMP2 15143154 1273177 These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of *dependent* [HB-EGF] release . Positive_regulation HBEGF MMP2 18986098 1983713 Leptin increased extracellular release of [HB-EGF] and TGFalpha and this was *blocked* by inhibitors . Positive_regulation HBEGF MMP2 20117092 2219722 Galphaq was found to *mediate* the UVB induced [HB-EGF] secretion by sequential activation of phospholipase C (PLC) , protein kinase Cdelta (PKCdelta) , and . Positive_regulation HBEGF MMP20 15143154 1273178 These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of *dependent* [HB-EGF] release . Positive_regulation HBEGF MMP20 18986098 1983714 Leptin increased extracellular release of [HB-EGF] and TGFalpha and this was *blocked* by inhibitors . Positive_regulation HBEGF MMP21 15143154 1273165 These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of *dependent* [HB-EGF] release . Positive_regulation HBEGF MMP21 18986098 1983700 Leptin increased extracellular release of [HB-EGF] and TGFalpha and this was *blocked* by inhibitors . Positive_regulation HBEGF MMP24 15143154 1273179 These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of *dependent* [HB-EGF] release . Positive_regulation HBEGF MMP24 18986098 1983715 Leptin increased extracellular release of [HB-EGF] and TGFalpha and this was *blocked* by inhibitors . Positive_regulation HBEGF MMP25 15143154 1273162 These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of *dependent* [HB-EGF] release . Positive_regulation HBEGF MMP25 18986098 1983697 Leptin increased extracellular release of [HB-EGF] and TGFalpha and this was *blocked* by inhibitors . Positive_regulation HBEGF MMP26 15143154 1273163 These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of *dependent* [HB-EGF] release . Positive_regulation HBEGF MMP26 18986098 1983698 Leptin increased extracellular release of [HB-EGF] and TGFalpha and this was *blocked* by inhibitors . Positive_regulation HBEGF MMP27 15143154 1273164 These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of *dependent* [HB-EGF] release . Positive_regulation HBEGF MMP27 18986098 1983699 Leptin increased extracellular release of [HB-EGF] and TGFalpha and this was *blocked* by inhibitors . Positive_regulation HBEGF MMP28 15143154 1273166 These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of *dependent* [HB-EGF] release . Positive_regulation HBEGF MMP28 18986098 1983701 Leptin increased extracellular release of [HB-EGF] and TGFalpha and this was *blocked* by inhibitors . Positive_regulation HBEGF MMP3 15143154 1273180 These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of *dependent* [HB-EGF] release . Positive_regulation HBEGF MMP3 16603724 1545143 The pathways include the activation of Src kinase and the release of [HB-EGF] as a *consequence* of activation . Positive_regulation HBEGF MMP3 18986098 1983716 Leptin increased extracellular release of [HB-EGF] and TGFalpha and this was *blocked* by inhibitors . Positive_regulation HBEGF MMP7 15143154 1273181 These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of *dependent* [HB-EGF] release . Positive_regulation HBEGF MMP7 18986098 1983717 Leptin increased extracellular release of [HB-EGF] and TGFalpha and this was *blocked* by inhibitors . Positive_regulation HBEGF MMP7 21273532 2419762 Collectively , these findings indicate that ACh induced cell migration is mediated by *mediated* release of [HBEGF] , an ERBB ligand that activates ERBB1 and downstream ERK and PI3K signaling . Positive_regulation HBEGF MMP8 15143154 1273182 These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of *dependent* [HB-EGF] release . Positive_regulation HBEGF MMP8 18986098 1983718 Leptin increased extracellular release of [HB-EGF] and TGFalpha and this was *blocked* by inhibitors . Positive_regulation HBEGF MMP9 15143154 1273183 These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of *dependent* [HB-EGF] release . Positive_regulation HBEGF MMP9 18986098 1983719 Leptin increased extracellular release of [HB-EGF] and TGFalpha and this was *blocked* by inhibitors . Positive_regulation HBEGF NFKB1 17001310 1716321 Using RNA interference , we demonstrated that the chemotherapy induced [HB-EGF] was largely *dependent* on activator protein-1 (AP-1) and activation . Positive_regulation HBEGF NOX4 23850346 2844285 Enzyme linked immunosorbent assay studies revealed that and ADAM17 *mediated* the release of mature [heparin binding EGF-like growth factor] ( HB-EGF ) , which played a critical role in the Ang II-induced EGFR activation . Positive_regulation HBEGF NPTX1 20208558 2259506 Furthermore , we discover that induction of HB-EGF is dependent on reactive oxygen species and p38-MAPK signaling but not ERK and that the transcription factor SP-1 is involved in *induced* [HB-EGF] transcription . Positive_regulation HBEGF NRD1 16923819 1626837 These results indicate the essential *role* of in [HB-EGF] ectodomain shedding and reveal how the shedding is regulated by the modulation of sheddase activity . Positive_regulation HBEGF NUP43 11171084 783776 Both MAPK activation and [HB-EGF] mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation HBEGF OLR1 15380451 1298427 [Heparin binding EGF-like growth factor] *induces* expression of in vascular smooth muscle cells . Positive_regulation HBEGF OLR1 15380451 1298430 Here we show that heparin binding epidermal growth factor-like growth factor ( [HB-EGF] ) , a potent mitogen for vascular smooth muscle cells , *induces* expression in cultured bovine aortic smooth muscle cells . Positive_regulation HBEGF PAF1 17322418 1747803 Increased alkaline phosphatase ( AP ) activity after PAF treatment in AP-HB-EGF fusion construct transfected SMCs indicated that *induced* the release of [HB-EGF] within 1 min. Gelatin zymography data showed that PAF stimulated MMP-2 activity and MMP-9 activity within 1 min . Positive_regulation HBEGF PAF1 7713868 298112 These results suggest a potential *role* of in [HB-EGF] expression and provide evidence that this stimulation may occur through increased kappa B binding activity . Positive_regulation HBEGF PDLIM7 17361012 1777668 Epidermal growth factor receptor (EGFR) ligands ( transforming growth factor alpha ( TGFalpha ) , [heparin binding EGF-like growth factor] and epiregulin ) are constitutively *induced* by , leading to EGFR phosphorylation but also down-regulation , degradation or turn-over , with the appearance of cleaved EGFR fragments . Positive_regulation HBEGF PDX1 9360990 462443 Based on findings that the expression pattern was similar to that of the homeodomain containing transcription factor PDX-1 ( IDX-1/STF-1/IPF1 ) and that the regulatory region of the HB-EGF gene contained sequences similar to the PDX-1 binding A element , we examined whether could be a potential *activator* of [HB-EGF] gene expression . Positive_regulation HBEGF PLAU 17654528 1858064 Moreover , we found that exogenously added *stimulates* autocrine production of [HB-EGF] , and that blocking HB-EGF activity curbed DU-145 cell invasive potential . Positive_regulation HBEGF PPARD 17637826 1842246 enhances keratinocyte proliferation in psoriasis and *induces* [heparin binding EGF-like growth factor] . Positive_regulation HBEGF PRKCD 20117092 2219723 Galphaq was found to *mediate* the UVB induced [HB-EGF] secretion by sequential activation of phospholipase C (PLC) , , and matrix metaloprotease-2 (MMP-2) . Positive_regulation HBEGF PTGS2 20117092 2219719 In this study , we aimed to elucidate the role and underlying mechanism of the alpha subunit of Gq protein ( Galphaq ) in UVB induced [HB-EGF] secretion and *induction* . Positive_regulation HBEGF RABEPK 24043629 2857343 stimulates ADAM17 activity and EGFR activation in colonic epithelial cells and *increases* [HB-EGF] levels in blood from WT mice , but not from mice with intestinal epithelial cell-specific ADAM17 deletion . Positive_regulation HBEGF RAF1 7649477 319139 Activation of delta : ER and a conditional oncogenic form of B-Raf , delta B-RAF : ER , *resulted* in rapid and sustained induction of [HB-EGF] mRNA expression and secretion of mature HB-EGF from cells . Positive_regulation HBEGF RALA 21179550 2358300 *induced* the expression of active [HB-EGF] and erbB1 . Positive_regulation HBEGF RALA 21179550 2358303 Our results indicate that ( i ) induced in vitro and in vivo keratinocyte proliferation is a CD44 dependent phenomenon and *requires* the presence of HA , [HB-EGF] , erbB1 and MMPs , ( ii ) RAL and HAFi show a synergy in vitro and in vivo in mouse skin , and ( iii ) the combination of RAL and HAFi seems to have an important therapeutic effect in dermatoporosis . Positive_regulation HBEGF RELA 17001310 1716322 Using RNA interference , we demonstrated that the chemotherapy induced [HB-EGF] was largely *dependent* on activator protein-1 (AP-1) and activation . Positive_regulation HBEGF S1PR2 10354366 617783 Similar transfection with Edg-3 plus -5 antisense plasmids suppressed Tsup-1 cell levels of immunoreactive , but not Edg-2 or -4 , and concurrently reduced S1P- , but not LPA- , *induced* Tsup-1 cell increases in both [HB-EGF] and susceptibility to DT . Positive_regulation HBEGF S1PR3 10354366 617782 Similar transfection with Edg-3 plus -5 antisense plasmids suppressed Tsup-1 cell levels of immunoreactive and -5 , but not Edg-2 or -4 , and concurrently reduced S1P- , but not LPA- , *induced* Tsup-1 cell increases in both [HB-EGF] and susceptibility to DT . Positive_regulation HBEGF SELE 10210777 607670 Thus physiologically , transient destruction of LN and expression of VCAM-1 , and fibronectin at sites of inflammation , may locally *induce* [HB-EGF] overexpression . Positive_regulation HBEGF SLC33A1 15143154 1273158 Although the Tyr319 residue of the AT1-R has been proposed to be an essential regulator of EGF-R transactivation , stimulation of wild-type and mutant ( Y319F ) expressed in COS-7 cells *caused* EGF-R transactivation and subsequent ERK1/2 phosphorylation through release of [HB-EGF] in a Src dependent manner . Positive_regulation HBEGF SP1 19201846 2033826 was recruited to three sites within the first 2 kb of the HB-EGF promoter following stimulation , and the site located at -83/-54 was *required* for [HB-EGF] promoter activity . Positive_regulation HBEGF SP1 20208558 2259490 Furthermore , we discover that induction of [HB-EGF] is dependent on reactive oxygen species and p38-MAPK signaling but not ERK and that the is *involved* in NPI-0052 induced HB-EGF transcription . Positive_regulation HBEGF SRC 11290747 819845 Experiments with various chemical inhibitors and dominant inhibitory mutants demonstrate that EGFR dependent activation of the ERK cascade after alpha(2A)AR stimulation requires Gbetagamma subunits upstream and dynamin dependent endocytosis downstream of HB-EGF shedding and EGFR activation , whereas kinase activity is *required* both for the release of [HB-EGF] and for HB-EGF mediated ERK2 phosphorylation . Positive_regulation HBEGF STAT3 17822789 1817471 [HB-EGF] *induces* delayed activation via NF-kappaB mediated IL-6 secretion in vascular smooth muscle cell . Positive_regulation HBEGF STAT3 17822789 1817484 Again , the late activation of STAT3 by HB-EGF was abolished by both Bay117082 and IL-6 neutralizing antibody ( 1 microg/ml ) indicating IL-6 is a key molecule in the delayed *activation* of by [HB-EGF] . Positive_regulation HBEGF TGFA 8060360 268231 Several cell lines expressed [HB-EGF] mRNA transcripts , and the transcript level was *enhanced* by HB-EGF , as well as by 12-O-tetradecanoylphorbol-13-acetate and ( TGF-alpha ) . Positive_regulation HBEGF TGFA 9796995 543504 When added to the medium , , basic fibroblast growth factor , or HB-EGF rapidly *induced* [HB-EGF] mRNA expression . Positive_regulation HBEGF TGFB1 10544013 563931 *Induction* of [HB-EGF] by was not affected by pretreatment with the MEK inhibitor PD-98059 while inhibition of protein kinase C either partially ( calphostin C ) or completely ( staurosporin ) blocked induction . Positive_regulation HBEGF TNF 1577791 187538 However , and interleukin-1 beta markedly *increased* [HB-EGF] mRNA levels in HUVEC by 12- and 7-fold , respectively , and induction of the gene by TNF-alpha was both dose- and time dependent . Positive_regulation HBEGF TNF 1577791 187540 In *response* to , [HB-EGF] mRNA levels quickly increased and peaked at 1 h , indicating that HB-EGF belongs to the family of immediate early genes . Positive_regulation HBEGF TNF 1577791 187542 In nuclear run-off experiments , *increased* the rate of [HB-EGF] gene transcription by 3.2-fold . Positive_regulation HBEGF UMOD 10210777 607667 In addition , we demonstrate that binding to LN , through the beta1 integrin VLA-6 , down *regulates* [HB-EGF] expression . Positive_regulation HBEGF VEGFA 21854110 2496059 The results suggested that is *induced* by [HB-EGF] and AR through mechanisms involving MAP kinase . Positive_regulation HBEGF WDR61 17322418 1747804 Increased alkaline phosphatase ( AP ) activity after PAF treatment in AP-HB-EGF fusion construct transfected SMCs indicated that *induced* the release of [HB-EGF] within 1 min. Gelatin zymography data showed that PAF stimulated MMP-2 activity and MMP-9 activity within 1 min . Positive_regulation HBEGF WDR61 7713868 298113 These results suggest a potential *role* of in [HB-EGF] expression and provide evidence that this stimulation may occur through increased kappa B binding activity . Positive_regulation HBZ MAP2K6 20162623 2236250 Conversely , expression of ( MKK) 6b ( E ) , a constitutive activator of p38 , significantly *activated* [zeta-globin] promoter . Positive_regulation HCL1 CA12 2864736 51504 Knowing the in vitro and in vivo gastric secretory effects of beta-adrenergic agonists and antagonists , as well as the *role* of in the gastric [HCl] production , we investigated the effect of some beta-adrenoceptor agonists ( isoprenaline and orciprenaline ) and antagonists ( propranolol , timolol , atenolol , pindolol , acebutolol , metoprolol , exoxprenolol ) on the purified , human red blood cell and gastric mucosa carbonic anhydrase . Positive_regulation HCL1 TNF 18651847 1967044 At 2 h , minocycline [HCl] *induced* high levels of IL-10 , and IFNgamma , while CHX reduced the levels of TNFalpha and IFNgamma . Positive_regulation HCL1 TNF 9136953 427882 The pathogenetic *role* of in [HCL] prompted us to study the potential contribution of functionally important genetic polymorphisms of the TNF gene cluster in a large group of patients with HCL . Positive_regulation HCL2 CA12 2864736 51517 Knowing the in vitro and in vivo gastric secretory effects of beta-adrenergic agonists and antagonists , as well as the *role* of in the gastric [HCl] production , we investigated the effect of some beta-adrenoceptor agonists ( isoprenaline and orciprenaline ) and antagonists ( propranolol , timolol , atenolol , pindolol , acebutolol , metoprolol , exoxprenolol ) on the purified , human red blood cell and gastric mucosa carbonic anhydrase . Positive_regulation HCL2 TNF 18651847 1967047 At 2 h , minocycline [HCl] *induced* high levels of IL-10 , and IFNgamma , while CHX reduced the levels of TNFalpha and IFNgamma . Positive_regulation HCL2 TNF 9136953 427883 The pathogenetic *role* of in [HCL] prompted us to study the potential contribution of functionally important genetic polymorphisms of the TNF gene cluster in a large group of patients with HCL . Positive_regulation HCL3 CA12 2864736 51530 Knowing the in vitro and in vivo gastric secretory effects of beta-adrenergic agonists and antagonists , as well as the *role* of in the gastric [HCl] production , we investigated the effect of some beta-adrenoceptor agonists ( isoprenaline and orciprenaline ) and antagonists ( propranolol , timolol , atenolol , pindolol , acebutolol , metoprolol , exoxprenolol ) on the purified , human red blood cell and gastric mucosa carbonic anhydrase . Positive_regulation HCL3 TNF 18651847 1967050 At 2 h , minocycline [HCl] *induced* high levels of IL-10 , and IFNgamma , while CHX reduced the levels of TNFalpha and IFNgamma . Positive_regulation HCL3 TNF 9136953 427884 The pathogenetic *role* of in [HCL] prompted us to study the potential contribution of functionally important genetic polymorphisms of the TNF gene cluster in a large group of patients with HCL . Positive_regulation HDAC1 CAPN8 17986223 1850820 Interestingly , [SAP] did not *induce* caspase and activation , suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways . Positive_regulation HDAC1 EPHB2 15261456 1274494 Furthermore , inhibition of *blocked* [HDAC] inhibitor induced LL-37 expression in colonic and gastric cells . Positive_regulation HDAC1 FOXO1 19074897 2003040 FOXO1 mediated inhibition of the AR is partially attenuated by the histone deacetylase (HDAC) inhibitor trichostatin A. Accordingly , interacts with HDAC3 as shown by coimmunoprecipitation assays , and cotransfection of cells with FOXO1 and HDAC3 , but not [HDAC1] and HDAC2 , *results* in a greater inhibition of AR activity than in cells transfected with FOXO1 or HDAC3 individually . Positive_regulation HDAC1 IL1B 10958685 726154 We have investigated the ability of dexamethasone to regulate *induced* gene expression , histone acetyltransferase ( HAT ) and [histone deacetylase (HDAC)] activity . Positive_regulation HDAC1 IL1B 16847181 1588133 The messenger RNA expressions of [LARC] ( liver and activation regulated chemokine ) , GMCSF ( granulocyte-macrophage colony stimulating factor ) , epiregulin , ICAM1 ( intercellular adhesion molecule 1 ) , and TGFA ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation HDAC1 MAP2K6 15261456 1274500 Furthermore , inhibition of *blocked* [HDAC] inhibitor induced LL-37 expression in colonic and gastric cells . Positive_regulation HDAC1 TNF 10788429 688667 Acute phorbol 12-myristate 13-acetate pretreatment also inhibited *stimulated* [SAP] kinase activity , while chronic pretreatment reversed the effects of UTP . Positive_regulation HDAC1 TNF 24448807 2932997 In summary , our study demonstrates that LPS- and *induced* [NF-?Bp50-HDAC1] interaction represses BAMBI transcriptional activity , which contributes to TLR4 mediated enhancement of TGF-ß signaling in HSCs during liver fibrosis . Positive_regulation HDAC1 ZFP57 20808772 2314068 Levels of both and PcG proteins inversely correlated with those of reactive oxygen species ( ROS ) in senescing MEFs , but the treatment of Zfp277 ( -/- ) MEFs with an antioxidant *restored* the binding of [PRC2] but not PRC1 to the Ink4a/Arf locus . Positive_regulation HDAC2 CAPN8 17986223 1850847 Interestingly , [SAP] did not *induce* caspase and activation , suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways . Positive_regulation HDAC2 EPHB2 15261456 1274502 Furthermore , inhibition of *blocked* [HDAC] inhibitor induced LL-37 expression in colonic and gastric cells . Positive_regulation HDAC2 FOXO1 19074897 2003041 FOXO1 mediated inhibition of the AR is partially attenuated by the histone deacetylase (HDAC) inhibitor trichostatin A. Accordingly , interacts with HDAC3 as shown by coimmunoprecipitation assays , and cotransfection of cells with FOXO1 and HDAC3 , but not HDAC1 and [HDAC2] , *results* in a greater inhibition of AR activity than in cells transfected with FOXO1 or HDAC3 individually . Positive_regulation HDAC2 IL1B 10958685 726155 We have investigated the ability of dexamethasone to regulate *induced* gene expression , histone acetyltransferase ( HAT ) and [histone deacetylase (HDAC)] activity . Positive_regulation HDAC2 IL1B 16847181 1588135 The messenger RNA expressions of [LARC] ( liver and activation regulated chemokine ) , GMCSF ( granulocyte-macrophage colony stimulating factor ) , epiregulin , ICAM1 ( intercellular adhesion molecule 1 ) , and TGFA ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation HDAC2 MAP2K6 15261456 1274508 Furthermore , inhibition of *blocked* [HDAC] inhibitor induced LL-37 expression in colonic and gastric cells . Positive_regulation HDAC2 TNF 10788429 688668 Acute phorbol 12-myristate 13-acetate pretreatment also inhibited *stimulated* [SAP] kinase activity , while chronic pretreatment reversed the effects of UTP . Positive_regulation HDAC2 ZFP57 20808772 2314086 Levels of both and PcG proteins inversely correlated with those of reactive oxygen species ( ROS ) in senescing MEFs , but the treatment of Zfp277 ( -/- ) MEFs with an antioxidant *restored* the binding of [PRC2] but not PRC1 to the Ink4a/Arf locus . Positive_regulation HDAC3 CCND1 21901538 2521953 We also found that when down regulation of p65 , the expression of and Bc1-2 decreased , and the expression of [SMRT] *increased* in vitro and vivo . Positive_regulation HDAC3 INPP4B 21224358 2379450 Optimal induction of by an androgen receptor *required* the expression of the transcriptional coactivator [NCoR] . Positive_regulation HDAC3 TGM2 20004474 2199806 [HDAC3] and snail *induced* by , exerted transcriptional repression on E-cadherin . Positive_regulation HDAC3 TLR7 21849441 2486227 Treatment with PPAR? and LXR ligands , but not GR ligands , prevented this *induced* clearance of [NCoR] from the LTR . Positive_regulation HDAC3 TNF 16371367 1519656 In this study , we demonstrate that nuclear translocation of [HDAC3] is *regulated* by , and this event is required for inhibition of transcriptional activity of PPARgamma by TNF-alpha . Positive_regulation HDAC3 TNF 17456789 1761150 An interaction of [histone deacetylase 3 (HDAC3)] and silencing mediator for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation HDAC4 TNF 22389387 2587488 It is also suggested in cultured vascular SMCs that *induced* [HDAC4] mediates vascular inflammation likely via VCAM-1 induction through ROS dependent NF-?B activation . Positive_regulation HDC HRH1 15514212 1359728 The present results indicate that [HDC] and HHR are expressed in arteriosclerotic lesion , and that GM-CSF *induces* HDC and expression in monocytes . Positive_regulation HDC IL1B 8653552 343046 Simultaneously *increased* activity of [HDC] and histamine-N-methyltransferase (HMT) , a neuronal histamine catabolizing enzyme . Positive_regulation HDC IL1B 9231747 444964 In the adherent cell fraction of the cultured diencephalon cells , [HDC] activity was also *enhanced* by LPS and . Positive_regulation HDC IL1B 9933502 589429 *increased* the activities of both [histidine decarboxylase (HDC)] , an HA synthesizing enzyme , and HA-N-methyltransferase (HMT) , an HA catabolizing enzyme . Positive_regulation HDC TNF 1385320 200744 IL-1 alpha , IL-1 beta , and TNF beta *induced* [HDC] and ODC , as does LPS . Positive_regulation HDC TNF 1472981 207219 6. The *induction* of [HDC] in the liver by LPS , IL-1 or was not suppressed by GalN and , at high doses , the response to LPS was enhanced . Positive_regulation HDC TNF 9831923 551595 *Induction* by interleukin-1 , and lipopolysaccharides of [histidine decarboxylase] in the stomach and prolonged accumulation of gastric acid . Positive_regulation HES1 EPHB2 16120441 1461057 The up-regulation of Hes-1 occurred both at the transcriptional and protein levels and by use of EGFR and MEK inhibitors we could show that the [Hes-1] response was *dependent* on activation of the MAP kinase . Positive_regulation HES1 EPHB2 24392017 2883964 Inhibition of the gamma-secretase complex prevented the *induced* [HES1] expression suggesting a NOTCH dependent mechanism . Positive_regulation HES1 JAG1 15578515 1344778 Coculture with Balb3T3 cells stably overexpressing *induced* transactivation of the [Hes1] promoter and increased expression of biliary lineage markers , such as cytokeratin-19 and gamma-glutamyl transpeptidase , in WB-F344 cells . Positive_regulation HES1 MAML3 21640102 2446202 Overexpression of by retroviral transduction in CaSki cells *resulted* in significant decreases in the mRNA levels of [Hes1] and Notch1 but had no effects on the levels of MAML1 , p53 or HPV E6/E7 . Positive_regulation HES1 MAP2K6 24392017 2883970 Inhibition of the gamma-secretase complex prevented the *induced* [HES1] expression suggesting a NOTCH dependent mechanism . Positive_regulation HES2 GNRH1 14678567 1183813 The results show that ( 0.1 microM ) *increased* the expression of inhibitory Smad7 mRNA in [HES] with a limited effect on ESC , while moderately increasing the common Smad4 and Smad7 protein levels in these cells ( P < 0.05 ) . Positive_regulation HES2 HES1 21744479 2562316 The [HES2] and HES5 gene promoters were found to be heavily methylated in most neuroblastoma lines , and gene expression could be *induced* through treatment with decitabine . Positive_regulation HES2 HES2 21744479 2562311 The [HES2] and HES5 gene promoters were found to be heavily methylated in most neuroblastoma lines , and gene expression could be *induced* through treatment with decitabine . Positive_regulation HES2 HES3 15610895 1357251 We also report here formation of the depurinating 3'-OH-HES-6'-N7Gua and 3'-OH-HES-6'-N3Ade adducts by reaction of with DNA or by *activation* of [3'-OH-HES] by tyrosinase , lactoperoxidase , prostaglandin H synthase or 3-methylcholanthrene induced rat liver microsomes in the presence of DNA . Positive_regulation HES2 HES3 21744479 2562315 The [HES2] and HES5 gene promoters were found to be heavily methylated in most neuroblastoma lines , and gene expression could be *induced* through treatment with decitabine . Positive_regulation HES2 HES4 21744479 2562314 The [HES2] and HES5 gene promoters were found to be heavily methylated in most neuroblastoma lines , and gene expression could be *induced* through treatment with decitabine . Positive_regulation HES2 HES5 21744479 2562313 The [HES2] and HES5 gene promoters were found to be heavily methylated in most neuroblastoma lines , and gene expression could be *induced* through treatment with decitabine . Positive_regulation HES2 HES6 21744479 2562312 The [HES2] and HES5 gene promoters were found to be heavily methylated in most neuroblastoma lines , and gene expression could be *induced* through treatment with decitabine . Positive_regulation HES2 HES7 21744479 2562310 The [HES2] and HES5 gene promoters were found to be heavily methylated in most neuroblastoma lines , and gene expression could be *induced* through treatment with decitabine . Positive_regulation HES2 IL17A 20876311 2337314 [HES] *induced* in the presence of IL-6 but did not promote Th1 or Th2 development under any conditions . Positive_regulation HES2 LPO 15610895 1357252 We also report here formation of the depurinating 3'-OH-HES-6'-N7Gua and 3'-OH-HES-6'-N3Ade adducts by reaction of HES-3',4'-Q with DNA or by *activation* of [3'-OH-HES] by tyrosinase , , prostaglandin H synthase or 3-methylcholanthrene induced rat liver microsomes in the presence of DNA . Positive_regulation HES2 NOTCH1 11390662 822866 Expression of a human sequence related to Drosophila Mam ( hMam-1 ) in mammalian cells augments *induction* of [Hairy Enhancer of split (HES)] promoters by signaling . Positive_regulation HES2 NOTCH1 16682003 1559694 Here we show that Hrt2 and Hes1 interact with RBP-Jkappa to negatively regulate *dependent* activation of Hrt and [Hes] expression . Positive_regulation HES2 NOTCH1 19185606 2043934 These results indicate that the mammalian auditory epithelium retains the ability to regulate Notch signaling and *dependent* [Hes] activity in response to cellular trauma and that the signaling is transient . Positive_regulation HES2 NOTCH1 19386663 2074994 Interestingly , unlike other developmental contexts in which [Hes] gene expression is *regulated* by signaling , Hairy1 expression in the CMZ is regulated by Wnt signaling . Positive_regulation HES2 NOTCH1 21266409 2380548 hJag1 activates , *induces* [Hes/Hey] genes and endogenous Jag1 in a non-cell-autonomous manner , which is consistent with lateral induction . Positive_regulation HES2 NOTCH2 11390662 822867 Expression of a human sequence related to Drosophila Mam ( hMam-1 ) in mammalian cells augments *induction* of [Hairy Enhancer of split (HES)] promoters by signaling . Positive_regulation HES2 NOTCH2 16682003 1559695 Here we show that Hrt2 and Hes1 interact with RBP-Jkappa to negatively regulate dependent *activation* of Hrt and [Hes] expression . Positive_regulation HES2 NOTCH2 19185606 2043935 These results indicate that the mammalian auditory epithelium retains the ability to regulate Notch signaling and *dependent* [Hes] activity in response to cellular trauma and that the signaling is transient . Positive_regulation HES2 NOTCH2 19386663 2074995 Interestingly , unlike other developmental contexts in which [Hes] gene expression is *regulated* by signaling , Hairy1 expression in the CMZ is regulated by Wnt signaling . Positive_regulation HES2 NOTCH2 21266409 2380549 hJag1 activates , *induces* [Hes/Hey] genes and endogenous Jag1 in a non-cell-autonomous manner , which is consistent with lateral induction . Positive_regulation HES2 NOTCH3 11390662 822868 Expression of a human sequence related to Drosophila Mam ( hMam-1 ) in mammalian cells augments *induction* of [Hairy Enhancer of split (HES)] promoters by signaling . Positive_regulation HES2 NOTCH3 16682003 1559696 Here we show that Hrt2 and Hes1 interact with RBP-Jkappa to negatively regulate *dependent* activation of Hrt and [Hes] expression . Positive_regulation HES2 NOTCH3 19185606 2043936 These results indicate that the mammalian auditory epithelium retains the ability to regulate Notch signaling and *dependent* [Hes] activity in response to cellular trauma and that the signaling is transient . Positive_regulation HES2 NOTCH3 19386663 2074996 Interestingly , unlike other developmental contexts in which [Hes] gene expression is *regulated* by signaling , Hairy1 expression in the CMZ is regulated by Wnt signaling . Positive_regulation HES2 NOTCH3 21266409 2380550 hJag1 activates , *induces* [Hes/Hey] genes and endogenous Jag1 in a non-cell-autonomous manner , which is consistent with lateral induction . Positive_regulation HES2 NOTCH4 11390662 822869 Expression of a human sequence related to Drosophila Mam ( hMam-1 ) in mammalian cells augments *induction* of [Hairy Enhancer of split (HES)] promoters by signaling . Positive_regulation HES2 NOTCH4 16682003 1559697 Here we show that Hrt2 and Hes1 interact with RBP-Jkappa to negatively regulate dependent *activation* of Hrt and [Hes] expression . Positive_regulation HES2 NOTCH4 19185606 2043937 These results indicate that the mammalian auditory epithelium retains the ability to regulate Notch signaling and *dependent* [Hes] activity in response to cellular trauma and that the signaling is transient . Positive_regulation HES2 NOTCH4 19386663 2074997 Interestingly , unlike other developmental contexts in which [Hes] gene expression is *regulated* by signaling , Hairy1 expression in the CMZ is regulated by Wnt signaling . Positive_regulation HES2 NOTCH4 21266409 2380551 hJag1 activates , *induces* [Hes/Hey] genes and endogenous Jag1 in a non-cell-autonomous manner , which is consistent with lateral induction . Positive_regulation HES2 RBPJ 12615665 1079843 The complex , in turn , *upregulates* expression of primary target genes of Notch signaling , such as hairy and enhancer of split (HES) and [HES related repressor protein (HERP)] transcriptional repressors . Positive_regulation HES2 RBPJ 15254753 1271922 Activation of Notch signaling pathway leads to transcriptional *activation* of [Hes] family genes through the interaction between Notch intracellular domain and ( CSL ) . Positive_regulation HES2 TYR 15610895 1357250 We also report here formation of the depurinating 3'-OH-HES-6'-N7Gua and 3'-OH-HES-6'-N3Ade adducts by reaction of HES-3',4'-Q with DNA or by *activation* of [3'-OH-HES] by , lactoperoxidase , prostaglandin H synthase or 3-methylcholanthrene induced rat liver microsomes in the presence of DNA . Positive_regulation HES3 HES2 15610895 1357264 We also report here formation of the depurinating 3'-OH-HES-6'-N7Gua and 3'-OH-HES-6'-N3Ade adducts by reaction of [HES-3',4'-Q] with DNA or by *activation* of <3'-OH-HES> by tyrosinase , lactoperoxidase , prostaglandin H synthase or 3-methylcholanthrene induced rat liver microsomes in the presence of DNA . Positive_regulation HES3 MAMLD1 18162467 1869459 ( MAMLD1 or CXorf6 ) *transactivates* the [Hes3] promoter , augments testosterone production , and contains the SF1 target sequence . Positive_regulation HES3 MAMLD1 18162467 1869460 These results suggest that *transactivates* the [Hes3] promoter , augments testosterone production , and contains the SF1 target sequence , thereby providing the first clue to clarify the biological role of CXorf6 . Positive_regulation HES5 HES2 21744479 2562318 The HES2 and [HES5] gene promoters were found to be heavily methylated in most neuroblastoma lines , and gene expression could be *induced* through treatment with decitabine . Positive_regulation HES5 JAG1 12357247 994172 During mammalian central nervous system ( CNS ) development , contact mediated activation of Notch1 receptors on oligodendrocyte precursors by the ligand *induces* [Hes5] , which inhibits maturation of these cells . Positive_regulation HEXA IL1B 18592145 1941332 Stimulation of synoviocytes by in cell cultures significantly *increased* the activity of HEX , [HEX-A] , and GluA in both compartments , as well as of GAL , MAN , and FUC in the intracellular compartment . Positive_regulation HEY1 JAG1 14976548 1213141 Here we report that expression of the hairy/enhancer-of-split related transcriptional repressor [Hey1] , and the Notch-ligand , was *induced* by TGF-beta at the onset of EMT in epithelial cells from mammary gland , kidney tubules , and epidermis . Positive_regulation HEY1 JAG1 14976548 1213146 The EMT phenotype , biphasic *activation* of [Hey1] , and delayed expression of were induced by TGF-beta in wild-type , but not in Smad3-deficient , primary mouse kidney tubular epithelial cells . Positive_regulation HEY1 JAG1 24651014 2925931 In turn , upregulation of on ECs reciprocally *induces* [Notch2-Hey1] in LCs . Positive_regulation HFE TF 10984552 732196 In the human cell lines , Caco-2 ( small intestinal phenotype upon differentiation ) and K562 ( erythroleukaemic ) [HFE] , in the *presence* of iron saturated , co-localized with transferrin receptors in an early endosome compartment using confocal immunofluorescence microscopy . Positive_regulation HFE TF 17003411 1618380 [HFE] is the principal regulator of iron homeostasis , and the process *involves* interaction with , transferrin receptor (TfR)-2 , and beta2-microglobulin (beta2M) . Positive_regulation HFE TF 18755804 1975332 The observations that the peptide hormone gastrin interacts with in vitro and that circulating gastrin concentrations are *increased* in the iron loading disorder [hemochromatosis] suggest a possible link between gastrin and iron homeostasis . Positive_regulation HFE TNF 12940442 1133277 Our aim was to study the *role* of and its promoter polymorphisms in the phenotypic expression of [hemochromatosis] in individuals with and without the C282Y mutation . Positive_regulation HGF ANGPT1 16638932 1589757 Interestingly , Ang2 , an antagonist ligand of Tie2 , inhibited *induced* [HGF] production and Ang1 induced SMC migration . Positive_regulation HGF CCND1 11850817 913067 We here report that [HGF/SF] can *induce* expression in mouse melanoma cells , and that this up-regulation is mediated in part by the activating transcription factor-2 ( ATF-2 ) . Positive_regulation HGF CD14 10225543 610258 Furthermore , the LPS effect on [HGF] was not *mediated* by . Positive_regulation HGF CD14 11725828 884325 These results suggest that LPS induces TGFbeta and [HGF] production *mediated* by in cultured human colon cancer cell lines . Positive_regulation HGF CD14 8945531 400309 We therefore investigated the *role* of , an LPS receptor , in stimulation of [HGF] by LPS . Positive_regulation HGF CTGF 18829614 2034587 [HGF] *induced* a transient expression of , which was maximal after 6 h and returned to baseline after 24 h. Coincubation with TGF-beta increased CTGF protein at 6 h , whereas HGF significantly decreased CTGF induction by TGF-beta after 24 h . Positive_regulation HGF EPHB2 11287413 819807 Conversely , [HGF] *induced* a sustained ( at least 12 h ) activation of in the cells . Positive_regulation HGF EPHB2 11533045 868826 [HGF] *induced* strong activation of in HepG2 cells . Positive_regulation HGF EPHB2 11784715 916707 In addition , [HGF] *induced* association of paxillin and activated , correlating with a gel retardation of paxillin that was prevented with the ERK inhibitor U0126 . Positive_regulation HGF EPHB2 14636584 1171270 In the present study we demonstrate that [HGF] stimulates the localization of ERK to sites of cell-matrix interactions and that this is *mediated* by the tyrosine phosphorylation dependent association of inactive and the focal adhesion complex protein paxillin . Positive_regulation HGF EPHB2 15555922 1340107 Preventing Akt activation with the phosphatidylinositol-3 (PI-3) kinase inhibitor LY294002 blocked the [HGF] survival response , and inhibition of activation with the MEK inhibitors PD98059 or U0126 *reduced* the HGF survival response and the neurite growth promoting effects of HGF . Positive_regulation HGF EPHB2 16189274 1507737 In MET positive DLBCL cells , [HGF] *induces* MEK dependent activation of and PI3K dependent phosphorylation of PKB , GSK3 , and FOXO3a . Positive_regulation HGF EPHB2 16724983 1565615 In contrast , [HGF] did not *induce* phosphorylation of and JNK . Positive_regulation HGF EPHB2 16912161 1601780 In addition , the *activation* of by [HGF] was reduced , at least in part , by small interfering RNAs against Rap1 and a dominant negative Rap1 . Positive_regulation HGF EPHB2 17154373 1678838 Consistently , HGF inhibits growth under HD but stimulates growth under LD . [HGF] *induced* sustained high activation under HD as compared to LD . Positive_regulation HGF EPHB2 22261330 2564490 Furthermore , Immunoblotting studies revealed that [HGF] *induced* phosphorylation of , and pre-treatment with U0126 , a MAPK/ERK inhibitor , partially inhibited hHGF induced increase in AQP3 expression . Positive_regulation HGF F3 12372819 1019641 Unusual proteolytic *activation* of [pro-hepatocyte growth factor] by plasma kallikrein and XIa . Positive_regulation HGF HAS3 19507223 2098227 [HGF] *induced* the upregulation of MMP-2 , -9 , and , and downregulated the expression of procollagen type I. Histologically , aged vocal folds treated with HGF revealed decreased collagen deposition , and increased deposition of HA , compared to sham treated vocal folds . Positive_regulation HGF IL1B 10065948 593536 Furthermore , IL-1beta mRNA expression in the HGF was synergistically increased when [HGF] directly interacted with lymphoid cells in the *presence* of exogeneous . Positive_regulation HGF IL1B 10082276 597717 dramatically increased prostaglandin E2 production and significantly *stimulated* [hepatocyte growth factor] synthesis . Positive_regulation HGF IL1B 10207838 606917 The present study investigated the effect of prostaglandin ( PG ) E2 and PGI2 on intercellular adhesion molecule-1 ( ICAM-1 ) expression in *stimulated* [human gingival fibroblasts (HGF)] . Positive_regulation HGF IL1B 10207838 606920 Indomethacin completely inhibited the production of PGE2 and 6-keto-PGF1 alpha in *stimulated* [HGF] . Positive_regulation HGF IL1B 10207838 606921 Both agents downregulated ICAM-1 expression in *stimulated* [HGF] . Positive_regulation HGF IL1B 10207838 606922 These results suggest that PGE2 and PGI2 downregulate ICAM-1 expression in *stimulated* [HGF] through a cAMP dependent mechanism and that intracellular cAMP elevation in HGF may control inflammatory and immune responses in periodontal disease . Positive_regulation HGF IL1B 10942208 721298 Northern hybridization analysis revealed that ( 200 pg/ml ) *increased* the expression of COX-2 mRNA in [HGF] . Positive_regulation HGF IL1B 10942208 721299 Gel mobility shift assays with a radiolabelled COX-2-NFkappaB oligonucleotide ( nts-223 to-214 ) revealed an increase in the binding of nuclear proteins from *stimulated* [HGF] . Positive_regulation HGF IL1B 10970828 728834 In contrast , human skin fibroblasts exerted no SLPI stimulated increase in HGF production , despite the fact that *increased* [HGF] production with an intensity similar to that of human lung fibroblasts . Positive_regulation HGF IL1B 11201045 762163 We have previously demonstrated that PGE2 down-regulates intercellular adhesion molecule-1 ( ICAM-1 ) expression in *stimulated* [human gingival fibroblasts (HGF)] . Positive_regulation HGF IL1B 11201045 762165 In the present study , we investigated which COX was involved in down-regulation of ICAM-1 expression by PGE2 in *stimulated* [HGF] and which subtypes of EP receptors modulated the ICAM-1 expression . Positive_regulation HGF IL1B 11201045 762167 NS-398 , a specific COX-2 inhibitor , completely inhibited PGE2 production by *stimulated* [HGF] , as did indomethacin , a COX-1/COX-2 inhibitor . Positive_regulation HGF IL1B 11201045 762168 Analysis of these data suggests that COX-2 derived PGE2 down-regulates ICAM-1 expression via EP2/EP4 receptors in *stimulated* [HGF] . Positive_regulation HGF IL1B 11585122 865980 In conclusion , we suggest that PGF2alpha increases MMP-1 production in HGF and synergistically enhances MMP-1 production in *stimulated* [HGF] . Positive_regulation HGF IL1B 11717194 881918 Moreover , the adherence of *stimulated* [HGF] to activated lymphocytes was also inhibited by adenosine , which is in part explained by the fact that adenosine down-regulated the IL-1beta induced expression of ICAM-1 on HGF . Positive_regulation HGF IL1B 11768718 890405 The production of total [HGF] *increased* in a dose dependent manner ( 4.7 to 9.2 times ) with . Positive_regulation HGF IL1B 11771938 899294 RT-PCR analysis demonstrated that CNTF increased levels of FGF-2 and nerve growth factor (NGF) mRNA and that *increased* NGF and [hepatocyte growth factor] mRNA levels . Positive_regulation HGF IL1B 11842936 912368 Reverse transcription-polymerase chain reaction analysis demonstrated that mRNA of EP1 , EP2 and EP4 , but not EP3 mRNA , was expressed in unstimulated and *stimulated* [HGF] . Positive_regulation HGF IL1B 12500176 1026682 These data suggest that the presence of retinal holes and may *lead* to activation of [HGF] , mitogen activated protein kinases (MAPK) , c-jun and extracellular matrix remodeling , resulting in proliferative and migratory cells in the wounded retina . Positive_regulation HGF IL1B 15652448 1364228 Further , *stimulated* [HGF] to produce IL-6 , IL-8 , PGE ( 2 ) and MMP-1 via activation of the 3 MAPKs and NF-kappaB , as inhibitors of each MAPK and NF-kappaB significantly suppressed the production of IL-1beta stimulated factors , though these pathways might also play distinct roles in IL-1beta activities . Positive_regulation HGF IL1B 16684952 1560070 OSM *induced* [HGF] secretion to a similar extent as in both a time- and dose dependent manner . Positive_regulation HGF IL1B 19959635 2210264 In the presence of IL-1beta , MMC treated corneal fibroblasts modified HCE cell migration through *induced* [HGF] secretion . Positive_regulation HGF IL1B 20726333 2306937 In cocultures , *induced* [HGF] release , while CPT-11 alone or combined with IL-1beta decreased HGF secretion . Positive_regulation HGF IL1B 3279116 90656 is a potent *inducer* of [HGF] in fibroblasts but has little stimulating effect on monocytes that spontaneously produce HGF . Positive_regulation HGF IL1B 7877083 287609 In contrast , indomethacin or PGE2 did not affect the accumulation of IL-6 mRNA in *stimulated* [HGF] . Positive_regulation HGF IL1B 8698619 375308 Thus , GB-d1 cell derived stimulates HGF production in stromal fibroblasts and [HGF] up-regulated in the fibroblasts *induces* invasion of GB-d1 cells . Positive_regulation HGF IL1B 8814069 383458 *induced* expression of rheumatoid synovial tissue fibroblast antigenic HGF and [scatter factor] activity . Positive_regulation HGF IL1B 9220246 442536 Changes in the expression of [HGF] and KGF mRNAs and proteins in *response* to stimulation of cultured corneal stromal fibroblasts with IL-1 alpha and were monitored by Northern and Western blotting , respectively . Positive_regulation HGF IL1B 9284956 451873 Expression of [HGF/SF] transcript and protein was *up-regulated* mildly by epidermal growth factor (EGF) , transforming growth factor-alpha ( TGF-alpha ) , or platelet derived growth factor B ( PDGF-BB ) but markedly by and was more pronounced in limbal than in corneal fibroblasts . Positive_regulation HGF IL1B 9571196 501688 Among various potential stimulants tested , dramatically increased PGE2 production and significantly *stimulated* [HGF] production . Positive_regulation HGF IL1B 9571196 501691 IND significantly reduced both basal and *induced* PGE2 release and [HGF] production . Positive_regulation HGF IL1B 9617441 509628 Recombinant human *induced* [HGF] release . Positive_regulation HGF ITGB2 9085219 421434 These findings suggested that the adhesive interactions between lymphocytes and [HGF] was *mediated* at least by VLA integrins , and CD44/hyaluronate and that the heterotypic cell-cell interactions could mutually cause intracellular signal transduction . Positive_regulation HGF MAP2K6 16189274 1507743 In MET positive DLBCL cells , [HGF] *induces* dependent activation of ERK and PI3K dependent phosphorylation of PKB , GSK3 , and FOXO3a . Positive_regulation HGF PLAT 10064822 593462 These results are consistent with the hypothesis that [HGF/SF] plays a role in the development and maintenance of both the cerebral cortex and hippocampus , and that may *act* as a regulator of HGF/SF activity in these structures . Positive_regulation HGF PLAT 17538930 1751779 One potential mechanism for these effects is that both deficiency and tPA-STOP *reduce* [hepatocyte growth factor (HGF)] activation and c-Met phosphorylation in the liver after BDL . Positive_regulation HGF PLAT 8824331 385077 These results suggest that may play a regulatory role in the development and maintenance of the olfactory system by *activating* [HGF/SF] in the immediate vicinity of its receptor . Positive_regulation HGF PLAU 11391526 822925 Despite the fact that active complex is *critical* for [hepatocyte growth factor (HGF)] activation , no differences were detected between the IL-6 +/+ and -/- livers in HGF activation as measured by receptor phosphorylation . Positive_regulation HGF PLAU 1328201 197743 [Hepatocyte growth factor] *increases* ( u-PA ) and u-PA receptor expression in Madin-Darby canine kidney epithelial cells . Positive_regulation HGF PLAU 15849510 1399151 IGF-I and [HGF] cooperate to induce migration and invasion of CRC cells , and c-Met and are *required* for IGF-I mediated migration and invasion . Positive_regulation HGF PLAU 15869463 1439688 *Activation* of [hepatocyte growth factor] by is ionic strength dependent . Positive_regulation HGF PLAU 16140945 1450934 In addition , IGF-I and [HGF] *induced* and uPAR expression in L3.6pl cells . Positive_regulation HGF PLAU 19863693 2351041 Furthermore , host was *necessary* for the recruitment of neutrophilic granulocytes and the associated increase of [HGF] in livers with elevated TIMP-1 levels . Positive_regulation HGF PLAU 21709151 2455805 Furthermore , Mp expression of *regulated* the level of active [hepatocyte growth factor] , which is required for muscle fiber regeneration , in damaged muscle . Positive_regulation HGF PLAU 7822285 292946 We previously reported that the ( uPA ) *activates* [pro-HGF] in vitro . Positive_regulation HGF TGM2 8598211 351298 [Hepatocyte growth factor] *induces* activity that negatively regulates the growth signal in primary cultured hepatocytes . Positive_regulation HGF TNF 10326728 612845 rhIL-1 beta and rh *stimulated* [HGF] to produce intracellular IL-1 alpha , whereas rh interleukin-6 (IL-6) , rh interleukin-4 (IL-4) , and rh interferon (IFN)-gamma did not do so . Positive_regulation HGF TNF 10697805 579159 Both the agents downregulated ICAM-1 expression in *stimulated* [HGF] . Positive_regulation HGF TNF 11327082 807528 From these data , we suggest that PGF2alpha upregulates IL-6 production through FP receptors in HGF , that PGF2alpha synergistically enhances IL-6 production in IL-1beta- and *stimulated* [HGF] , and that PGF2alpha induced IL-6 production may be dependent on intracellular Ca2+ mobilization and be downregulated by PKC activation . Positive_regulation HGF TNF 12349897 992864 Gel mobility shift assays with a radiolabelled COX-2-NFkappaB oligonucleotide ( nts -223 to -214 ) revealed an increase in the binding of nuclear proteins from *stimulated* [HGF] . Positive_regulation HGF TNF 12445174 1017559 [Hepatocyte growth factor] in MNP is not directly *induced* by interferon-alpha , interferon-gamma or . Positive_regulation HGF TNF 1384479 200557 and interferon-gamma but no other cytokine tested *had* slightly stimulatory effects on [HGF] production . Positive_regulation HGF TNF 15541342 1336895 [HGF] production is *induced* by the activation of protein kinase A and protein kinase C-mediated pathways , interleukin (IL)-1 , , and epidermal growth factor (EGF) in mesenchymal cells . Positive_regulation HGF TNF 15629451 1362286 Candidates of the factors are inflammatory cytokines released by polymorphonuclear and mononuclear cells infiltrating the wounded area , but [HGF] production in human dermal fibroblasts is only slightly *induced* by interleukin (IL)-1 , or interferon (IFN)-gamma . Positive_regulation HGF TNF 16006475 1459230 IL-6 and are *involved* in the production of [HGF] by endometrial stromal cells and may be involved in the growth of endometriosis by an autocrine mechanism . Positive_regulation HGF TNF 16728464 1612353 Human progenitor cells from bone marrow or adipose tissue produce VEGF , [HGF] , and IGF-I in *response* to by a p38 MAPK dependent mechanism . Positive_regulation HGF TNF 16728464 1612359 We hypothesized that *stimulated* progenitor cell secretion of vascular endothelial growth factor ( VEGF ) , [hepatocyte growth factor (HGF)] , and insulin-like growth factor I (IGF-I) by a p38 mitogen activated protein kinase (MAPK) dependent mechanism . Positive_regulation HGF TNF 16728464 1612362 Secretion of VEGF , [HGF] , and IGF-I in hMSCs and hAPCs was significantly increased by *stimulation* with and was associated with increased activation of p38 MAPK . Positive_regulation HGF TNF 16728464 1612365 The p38 MAPK inhibitor decreased production of *stimulated* VEGF , [HGF] , and IGF-I in hMSCs and hAPCs . Positive_regulation HGF TNF 18234850 1876843 , LPS , and hypoxia significantly *increased* human MSC VEGF , FGF2 , [HGF] , and IGF-1 production versus controls . Positive_regulation HGF TNF 19438592 2078063 Interleukin (IL)-4 , IL-13 and CpG DNA up-regulated CXCR6 expression by *stimulated* [HGF] . Positive_regulation HGF TNF 19692652 2150940 and 4 ) TNFR1 acts to decrease basal TGF-alpha and *stimulated* [HGF] . Positive_regulation HGF TNF 20161853 2179372 Furthermore , *induced* secretion of IL-6 , IL-8 , EGF , [HGF] , TGF-alpha , epiregulin , and amphiregulin were compared among these keratinocytes . Positive_regulation HGF TNF 20161853 2179376 The significant induction of *increased* IL-6 , IL-8 , EGF , [HGF] , TGF-alpha , epiregulin , and amphiregulin , but the increase in these cytokines and growth factors were not different among normal skin , uninvolved , and involved psoriasis . Positive_regulation HGF TNF 20533298 2320224 Mechanism of *induced* migration and [hepatocyte growth factor] production in human mesenchymal stem cells . Positive_regulation HGF TNF 20533298 2320225 *increased* both [hepatocyte growth factor (HGF)] mRNA expression in MSCs and HGF secretion in conditioned medium . Positive_regulation HGF TNF 20533298 2320226 We conclude that can enhance human MSCs migration and *stimulate* their production of [HGF] . Positive_regulation HGF TNF 21411099 2438310 In ex vivo cultures of human AAA tissue , exogenously added [HGF] in the *presence* of ( TNF-a ) enhanced the secretion of anti-inflammatory cytokine interleukin-10 (IL-10) and suppressed the secretion of proinflammatory monocyte/macrophage chemotactic protein-1 (MCP-1) . Positive_regulation HGF TNF 22158049 2668172 Blocking p75 by short-hairpin RNA in cultured LLCs led to increases in TNF mediated apoptosis , as well as decreases in the constitutive and *mediated* expression of angiogenic growth factors ( VEGF , [HGF] , PLGF ) , and SDF-1a receptor CXCR4 . Positive_regulation HGF TNF 3545852 70417 Also , under optimal conditions the yield of HGF can attain as much as 10 ( 4 ) units/ml . ( TNF-alpha ) , which otherwise shares various properties with IL 1 , is a weak *inducer* of [HGF] . Positive_regulation HGF TNF 7593211 330316 Cultured follicular papilla cells secreted [HGF/SF] , measured by an enzyme linked immunoassay , in *response* to interleukin 1-alpha ( IL1-alpha , 10 ng/ml ) , ( TNF-alpha , 10 ng/ml ) , or tetradecanoylphorbolacetate ( 100 nM ) at levels ranging from 0.2 to 0.3 ng/mg protein/48 h. HGF/SF mRNA expressions , measured by the reverse transcription-polymerase chain reaction , were detected in follicular papilla cells , and were also stimulated by the three reagents . Positive_regulation HGF TNF 7681834 214391 *Enhancement* of human [hepatocyte growth factor] production by interleukin-1 alpha and -1 beta and by fibroblasts in culture . Positive_regulation HGF TNF 7853122 286925 The combination of IL-1 beta and TNF-alpha synergistically enhanced the secretion of IL-8 , whereas IFN-gamma suppressed IL-8 secretion by IL-1 beta- or *stimulated* [HGF] . Positive_regulation HGF TNF 7877083 287608 IL-6 secretion from either IL-1 beta- or *stimulated* [HGF] was enhanced by the inhibition of PGE2 synthesis with indomethacin . Positive_regulation HGF TNF 9409458 471470 In vitro stimulation by IL-1 beta , or phorbol 12-myristate 13-acetate *induced* an increase in total CD44 messenger RNA in [HGF] but not change in overall patterns of CD44 isoform expression . Positive_regulation HGF TP63 22521434 2607990 Using real-time RT-qPCR , Western blots , luciferase reporter assays , and siRNAs , as well as antibodies to specific signaling molecules we showed that [HGF] *induced* VDR gene expression , as well as up-regulated gene expression . Positive_regulation HHIP PDZK1 21653824 2459480 Although did not *increase* overall levels of the [hIP] , it increased its functional expression at the cell surface , enhancing ligand binding and cicaprost induced cAMP generation . Positive_regulation HIF1A CAPN8 17989922 1835751 Degradation of [HIF-1alpha] *required* intracellular calcium transients and activation . Positive_regulation HIF1A CCND1 18792914 2008960 Moreover , the soluble nickel induced degradation is dependent on its Thr286 residue and *requires* IKKalpha , but not [HIF-1alpha] , which are both reported to be involved in cyclin D1 down-regulation . Positive_regulation HIF1A EDN2 20574527 2280340 Here we found that in melanoma cells ET-1 , , and ET-3 through ET ( B ) R , *enhance* the expression and activity of [HIF-1alpha] and HIF-2alpha that in turn regulate the expression of vascular endothelial growth factor ( VEGF ) in response to ETs or hypoxia . Positive_regulation HIF1A EPHB2 12727858 1086455 Pharmacologic inhibition of phosphorylation *blocks* the induction of VEGF mRNA and [HIF-1alpha] protein expression in response to PGE ( 2 ) stimulation . Positive_regulation HIF1A EPHB2 14680833 1179178 In a variety of cell lines , the phosphorylation of [HIF-1alpha] is *dependent* on or p38 , two members of the mitogen activated protein kinase (MAPK) superfamily . Positive_regulation HIF1A EPHB2 14681237 1211312 Here , we found that SW elevation of VEGF-A expression in human osteoblasts to be mediated by Ras induced superoxide and *dependent* [HIF-1alpha] activation . Positive_regulation HIF1A EPHB2 14681237 1211320 In support of the observation that superoxide mediated the SW-induced activation and [HIF-1alpha] *transactivation* , we further demonstrated that scavenging of superoxide by superoxide dismutase and inhibition of ERK activity by PD98059 decreased HIF-1alpha activation and VEGF-A levels . Positive_regulation HIF1A EPHB2 18272284 1896133 PD98059 , inhibitor *reduced* [HIF-1 alpha] increased by TB4P . Positive_regulation HIF1A EPHB2 19098317 2047592 *Role* of PI3K/Akt and in mediating hypoxia induced expression of [HIF-1alpha] and VEGF in laser induced rat choroidal neovascularization . Positive_regulation HIF1A EPHB2 19768695 2168346 and p38 MAPK , but not reactive oxygen species ( ROS ) , ASK1 or PI 3-kinase , were *critical* for IgE mediated accumulation of [HIF-1alpha] , although the latter crucially affected degranulation . Positive_regulation HIF1A ID1 17426247 1723968 Although both the transcript and proteins levels of VEGF were induced by , only the protein expression of [HIF-1alpha] was *induced* without transcriptional changes in both human umbilical endothelial cells and MCF7 breast cancer cells . Positive_regulation HIF1A IL1B 11852072 913296 Normoxic *induction* of the [hypoxia-inducible factor 1alpha] by insulin and involves the phosphatidylinositol 3-kinase pathway . Positive_regulation HIF1A IL1B 12101082 962455 Recombinant human *induced* , in a time dependent manner , the nuclear translocation of [HIF-1 alpha] , an effect associated with up-regulating the activity of this transcription factor under normoxic conditions . Positive_regulation HIF1A IL1B 12101082 962457 The antioxidants , dimethyl sulfoxide ( DMSO ) and 1,3-dimethyl-2-thiourea ( DMTU ) , purported to be prototypical scavengers of H2O2 and *OH , attenuated , in a dose dependent manner , *induced* [HIF-1 alpha] nuclear translocation and activation . Positive_regulation HIF1A IL1B 12101082 962459 The NADPH-oxidase inhibitor , 4'-hydroxy-3'-methoxy-acetophenone ( HMAP ) , which may affect mitochondrial ROS production , attenuated *mediated* nuclear translocation and activation of [HIF-1 alpha] . Positive_regulation HIF1A IL1B 12101082 962463 Inhibition of the mitochondrion complex I nicotinamide adenine dinucleotide phosphate dependent oxidase by diphenylene iodonium ( DPI ) , which blocks the conversion of ubiquinone -- > ubiquinol , abrogated *dependent* nuclear translocation and activation of [HIF-1 alpha] . Positive_regulation HIF1A IL1B 12958148 1158158 *mediated* up-regulation of [HIF-1alpha] via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis . Positive_regulation HIF1A IL1B 15665520 1365596 The study shows that PI3K but not MAPKK-1 inhibition resulted in the loss of hypoxic and *induced* [HIF-1alpha] accumulation , whereas VEGF synthesis was reduced by either intervention . Positive_regulation HIF1A IL1B 15930287 1414476 significantly *increased* accumulation and nuclear translocation of [HIF-1alpha] under normoxic conditions and amplified hypoxic HIF-1 activation . Positive_regulation HIF1A IL1B 17015745 1629870 Suggesting functional significance , we found that expression of in the brain *induced* astrocytic expression of [HIF-1alpha] , VEGF-A , and BBB permeability . Positive_regulation HIF1A IL1B 17015745 1629873 In addition , we confirmed VEGF-A to be a potent inducer of BBB permeability and angiogenesis , and demonstrated the importance of *induced* [HIF-1alpha] in its regulation . Positive_regulation HIF1A IL1B 19390242 2082016 These data suggest that the profound effects of COX-2 silencing on inhibiting invasion , tumor growth and metastasis from MDA-MB-231 cells are dependent on the induction of *dependent* COX-2 and [HIF-1alpha] but are independent of hypoxia Positive_regulation HIF1A IL1B 19490965 2149461 Additionally , *stimulated* both [HIF-1alpha] and PAI-1 in articular chondrocytes , and the IL-1beta mediated induction of PAI-1 was inhibited partly by HIF-1alpha silencing . Positive_regulation HIF1A MAP2K6 15806152 1417454 Pharmacologic inhibition of phosphatidylinositol 3-kinase with LY294002 reduced the HIF-1alpha level in both normoxic and hypoxic A431 cells , whereas inhibition of the by PD98059 *reduced* the level of [HIF-1alpha] only in normoxic A431 cells . Positive_regulation HIF1A MAP2K6 16145048 1451578 The overexpression of Hsp90 , but not constitutive Akt or constitutive , *restored* [HIF-1alpha] expression in IGF stimulated or hypoxic cells but not in unstimulated cells . Positive_regulation HIF1A MAP2K6 19098317 2047601 *Role* of PI3K/Akt and in mediating hypoxia induced expression of [HIF-1alpha] and VEGF in laser induced rat choroidal neovascularization . Positive_regulation HIF1A MUC16 22869720 2646780 MUC1 stabilizes and *activates* [hypoxia-inducible factor 1 alpha] to regulate metabolism in pancreatic cancer . Positive_regulation HIF1A NEDD9 20442290 2256915 Importantly , the induction of expression significantly *enhances* hypoxia stimulated [HIF-1alpha] transcriptional activity by modulating the interaction between HIF-1alpha and its transcriptional cofactor p300 . Positive_regulation HIF1A SPHK1 18922940 1977389 The *dependent* stabilization of [HIF-1alpha] levels is mediated by the Akt/glycogen synthase kinase-3beta signaling pathway that prevents its von Hippel-Lindau protein mediated degradation by the proteasome . Positive_regulation HIF1A SPHK1 18922940 1977390 The pharmacologic and RNA silencing inhibition of activity *prevents* the accumulation of [HIF-1alpha] and its transcriptional activity in several human cancer cell lineages ( prostate , brain , breast , kidney , and lung ) , suggesting a canonical pathway . Positive_regulation HIF1A TLR7 20539755 2271669 In addition , we could show that stimulation *resulted* in an increase of [HIF-1alpha] controlled VEGF secretion . Positive_regulation HIF1A TLR7 21685248 2470957 [HIF1A] is *stabilized* by hypoxia but also by ligands under normoxic conditions . Positive_regulation HIF1A TLR7 21685248 2470967 The *induced* [HIF1A] controls a subset of proinflammatory genes that are insufficiently induced following hypoxia mediated HIF1A induction . Positive_regulation HIF1A TLR7 21685248 2470977 Thus , activation and hypoxia *stabilize* [HIF1A] via distinct signaling pathways , resulting in differential HIF1A dependent gene expression . Positive_regulation HIF1A TNF 11566189 863855 A non-hypoxic , ROS-sensitive pathway mediates *dependent* regulation of [HIF-1alpha] . Positive_regulation HIF1A TNF 11566189 863857 A non-hypoxic , reactive oxygen species ( ROS ) -sensitive pathway mediating *dependent* regulation of [hypoxia-inducible factor-1alpha] ( HIF-alpha ) was investigated in vitro . Positive_regulation HIF1A TNF 11566189 863859 *mediated* the translocation of [HIF-1alpha] , associated with up-regulating its activity under normoxia . Positive_regulation HIF1A TNF 11566189 863860 OH , attenuated *induced* [HIF-1alpha] activation , and blockading NADPH-oxidase by scavenging O ( 2-. ) reduced the activity of HIF-1alpha . Positive_regulation HIF1A TNF 11566189 863861 Inhibition of the mitochondrion complex I abrogated *dependent* activation of [HIF-1alpha] . Positive_regulation HIF1A TNF 12388069 1034946 NO and released from activated macrophages *stabilize* [HIF-1alpha] in resting tubular LLC-PK1 cells . Positive_regulation HIF1A TNF 12808024 1102186 *causes* accumulation of a ubiquitinated form of [hypoxia inducible factor-1alpha] through a nuclear factor-kappaB dependent pathway . Positive_regulation HIF1A TNF 12808024 1102188 In tubular LLC-PK1 or human embryonic kidney cells , *induced* accumulation of [HIF-1alpha] protein but not HIF-1alpha mRNA . Positive_regulation HIF1A TNF 15023385 1221982 The increase in [HIF-1alpha] expression *induced* by was partially blocked by pretreatment of the chondrocytes with inhibitors of NFkappaB or p38 MAP kinase . Positive_regulation HIF1A TNF 15604270 1346845 In tubular LLC-PK(1) cells , activation of nuclear factor kappaB (NFkappaB) by *resulted* in [HIF-1alpha] protein synthesis as determined by [ ( 35 ) S ] methionine pulse experiments . Positive_regulation HIF1A TNF 18438939 1938503 Our studies showed that , unlike a murine microglial cell line ( BV-2 ) , MO3.13 cells do not induce [HIF-1alpha] in the *presence* of . Positive_regulation HIF1A TNF 19766100 2147412 *induces* [HIF-1alpha] expression through activation of IKKbeta . Positive_regulation HIF1A TNF 19766100 2147417 We found that *enhances* [HIF-1alpha] protein expression in various breast cancer cell lines under either normoxic or hypoxia mimicking conditions , but has little effect on the HIF-1alpha mRNA level . Positive_regulation HIF1A TNF 19766100 2147419 Treatment of cells with the IKKbeta inhibitor Bay 11-7082 reduced the *induced* [HIF-1alpha] expression , suggesting that IKKbeta is required in this signaling pathway . Positive_regulation HIF1A TNF 19766100 2147420 Our findings indicate that *induced* [HIF-1alpha] accumulation is IKKbeta dependent , and may enable further understanding of the HIF-1alpha regulation by inflammatory signals . Positive_regulation HIPK1 TNF 15701637 1388710 Our study suggests that *induced* desumoylation and cytoplasmic translocation of [HIPK1] are critical in TNFalpha induced ASK1-JNK/p38 activation . Positive_regulation HIPK1 TNF 18219322 1876734 SENP1 mediates *induced* desumoylation and cytoplasmic translocation of [HIPK1] to enhance ASK1 dependent apoptosis . Positive_regulation HIPK1 TNF 18219322 1876738 Furthermore , the wild-type form of SENP1 enhances , whereas the catalytic-inactive mutant form or siRNA of SENP1 blocks , TNF induced desumoylation and cytoplasmic translocation of [HIPK1] as well as induced ASK1-JNK *activation* . Positive_regulation HIPK1 TNF 18219322 1876741 We conclude that SENP1 mediates *induced* desumoylation and translocation of [HIPK1] , leading to an enhanced ASK1 dependent apoptosis . Positive_regulation HIPK2 NES 16253240 1477134 Sumoylated [HIPK2] are deconjugated by SENP1 both in vitro and in cultured cells , and the desumoylation is *enhanced* either by the forced translocation of SENP1 into the nucleus or by the SENP1 mutant . Positive_regulation HIST1H2BK MAP2K6 9135066 427681 Moreover , inhibition of endogenous by a specific inhibitor , PD 098059 , *suppressed* the activation of [p96h2bk] by oncogenic Ras . Positive_regulation HIST1H3H MMP28 21436261 2421723 At the same time , inhibitor specifically *blocked* the adipogenic induction of [H3K9ac] . Positive_regulation HIST1H3H MMP7 21436261 2421738 At the same time , inhibitor specifically *blocked* the adipogenic induction of [H3K9ac] . Positive_regulation HIST1H3H TNF 18688044 1961010 *induced* inflammatory gene expression , [H3K4me2] levels , and recruitment of RNA polymerase II at the gene promoters were also enhanced in db/db VSMCs , demonstrating the formation of open chromatin poised for transcriptional activation in diabetes . Positive_regulation HIST1H4E EPHB2 17081988 1643156 Five minutes after hormone treatment , activation *leads* to phosphorylation of the progesterone receptor (PR) , activation of Msk1 , and recruitment of a complex of the three proteins to a [nucleosome] on the MMTV promoter . Positive_regulation HIST1H4E TLR7 11135578 794947 Lipopolysaccharide (LPS) induction of the gene encoding interleukin 12 p40 requires remodeling of a promoter encompassing [nucleosome] and the mediated *activation* of a c-Rel containing complex . Positive_regulation HIST2H2BE STK39 21212262 2391988 The MST1 is a that is activated upon apoptotic stimulation , which in turn *activates* its downstream targets , JNK/p38 , histone [H2B] and FOXO . Positive_regulation HIST4H4 IL1B 16174862 1507564 Chromatin immunoprecipitation assays revealed that , under basal conditions , acetylated [histone H4] associated with the region -978 to -710 of the iNOS promoter , a region rich in gene control elements and that significantly *increased* this binding , which was further accentuated by cotreatment with TSA . Positive_regulation HK1 EPHB2 21085672 2349940 Activation also induced [hexokinase] activity and expression in T cells , and both were similarly *dependent* on signaling . Positive_regulation HK2 ADRB2 24504055 2918685 *dependent* regulation of GLUT-1 and [HK-2] was determined by in vitro pharmacologic intervention . Positive_regulation HK2 ADRB2 24504055 2918693 The expression of [HK-2] was *regulated* by the activation of in 4T1 breast cancer cells primarily at the posttranscriptional level . Positive_regulation HK2 CTGF 18433544 1900207 To explore the *role* of exogenous in the collagen III synthesis of human renal tubular epithelial cell line [HK2] in vitro . Positive_regulation HK2 EPHB2 21085672 2349941 Activation also induced [hexokinase] activity and expression in T cells , and both were similarly *dependent* on signaling . Positive_regulation HK2 INPP4B 24051093 2851804 Of the glycolysis-regulatory genes , [hexokinase 2 (HK2)] was mainly *regulated* by and this regulation was mediated through the Akt-mTOR pathway . Positive_regulation HK2 TNF 19910630 2189356 We established an in vitro model of *stimulated* human proximal tubular epithelial ( [HK-2] ) cells to assess the possible effects of HES 130/0.42 and HES 200/0.5 on these activated cells . Positive_regulation HK2 UCA1 24890811 2951293 In this study , we show that lncRNA UCA1 promotes glycolysis in bladder cancer cells , and that *induced* [hexokinase 2 (HK2)] functions as an important mediator in this process . Positive_regulation HK3 EPHB2 21085672 2349942 Activation also induced [hexokinase] activity and expression in T cells , and both were similarly *dependent* on signaling . Positive_regulation HLA-A FAS 16902496 1692095 In short-term assays , expressing APC *induced* apoptosis in activated T cells and the constitutive presence of m-CD95L and [HLA-A1] expressing APC in long-term T cell cultures prevented the expansion of CD4 ( + ) and CD8 ( + ) HLA-A1-specific T cells and the development of HLA-A1-specific cytotoxicity . Positive_regulation HLA-A TNF 1697308 139518 but not IL-1 also *increases* [class I MHC] Ag expression . Positive_regulation HLA-A TNF 19195705 2049661 Stimulation with IFN-gamma and/or led to an increase of HLA-A*3014L secretion to a detectable level and *increased* [HLA-A*3001] expression up to 8-fold , but did not show any difference in the increase of mRNA levels between HLA-A*3014L and A*3001 . Positive_regulation HLA-A TNF 2105059 126872 Finally , *induced* [class I MHC] expression was inhibited strongly by IL-1 alpha . Positive_regulation HLA-A TNF 2433337 69350 *enhances* [HLA-A] , B,C and HLA-DR gene expression in human tumor cells . Positive_regulation HLA-B TNF 1292634 207772 Optimal *induction* of [HLA-B7] by at 24 h was shown to require a continuous presence of TNF . Positive_regulation HLA-B TNF 1292634 207775 Since TNF also induces IFN-beta in these cells and the latter cytokine itself has the capacity to upregulate HLA class I expression , we investigated the role of autocrine IFN-beta in the *induction* of [HLA-B7] by . Positive_regulation HLA-B TNF 22247344 2564223 and IFN-a , IFN-ß , and IFN-? significantly *activated* [HLA-B27] promoter in the U937 cell line , and IFN-? , the strongest activating factor , may induce the UPR in HLA-B27 expressing cells . Positive_regulation HLA-DRA CD14 15661814 1381988 Furthermore , the *upregulation* of CD80 , CD86 , [MHC class II] and interleukin-6 by ( + ) monocytes following activation with specific TLR ligands was decreased ( P < 0.05 ) in samples obtained following exercise compared with at rest . Positive_regulation HLA-DRA IL1B 1628893 191833 Among those cytokines , *had* a positive effect on IFN-gamma dependent induction of [MHC class II] genes . Positive_regulation HLA-DRA IL1B 8473727 216317 Simulating the effects of topically applied TNCB , intradermally injected ( but not IL-1 alpha or TNF alpha ) also *caused* enhancement of LC [MHC class II] expression . Positive_regulation HLA-DRA JAG1 12798309 1098749 The expression of [MHC class II] , CD86 , and CD83 Ags on DCs and CD40 ligand (L) associated IL-12 p70 production from DCs were *up-regulated* by the membrane . Positive_regulation HLA-DRA LBP 19265128 2045465 *up-regulated* DC expression of CD40 , CD80 , CD86 , and [MHC class II] molecules ; Positive_regulation HLA-DRA PECAM1 11899433 894255 The results show that exposure to LPG did not affect the expression of major histocompatibility complex ( [MHC) class II] and B7 , but *induced* an up-regulation of CD25 , and vascular endothelial (VE)-cadherin expression and a down-regulation of Mac-1 expression , by LC . Positive_regulation HLA-DRA TLR7 16619292 1551223 Comprehensive mutant analyses , electrophoretic mobility shift assays and chromatin immunoprecipitation assays , reveal that the functional interaction of NF-kappaB with the promoter element is necessary for the mediated [HLA-DRA] *induction* by CpG-DNA and LPS . Positive_regulation HLA-DRA TLR7 17563917 1763061 ES , but not AWH , inhibited BMDC cytokine and chemokine production and co-stimulatory molecule expression ( CD40 , CD86 and [MHC class II] ) *induced* by ligation . Positive_regulation HLA-DRA TLR7 18802111 1964591 We also found that ligands , and to some extent TNF-alpha , were able to *increase* the expression of [MHC class II] and CD83 in endothelial cells , which might suggest a role for fish endothelial cells and TNF-alpha in Ag presentation . Positive_regulation HLA-DRA TNF 11914744 925315 alone did not induce MHC class II expression , but *enhanced* IFN gamma induced [MHC class II] expression . Positive_regulation HLA-DRA TNF 11914744 925323 IFN gamma and synergistically *induced* [MHC class II] expression on insulinoma cells through the induction of CIITA ; Positive_regulation HLA-DRA TNF 12067408 955028 CD34 expression was gradually lost , so that by day 9 , the majority of the cells were CD34 ( - ) /CMRF-44 ( + ) . GM-CSF and also *induced* CD40 expression , and up-regulation of CD54 and [MHC class II] on CD34 ( + ) cells ; Positive_regulation HLA-DRA TNF 16154304 1499438 Our results demonstrate that BM injected once ip in mice at 10 and 20 mg/kg increased the cellular influx to the peritoneal cavity , the [MHC class II] expression and the spreading ability , and also *induced* the production of NO , and H ( 2 ) O ( 2 ) . Positive_regulation HLA-DRA TNF 18802111 1964590 We also found that TLR ligands , and to some extent , were able to *increase* the expression of [MHC class II] and CD83 in endothelial cells , which might suggest a role for fish endothelial cells and TNF-alpha in Ag presentation . Positive_regulation HLA-DRA TNF 1981601 148637 [MHC class II] expression could not be *induced* with or IL-1 alone but required prolonged stimulation with IFN gamma . Positive_regulation HLA-DRA TNF 20980264 2382330 induces macroautophagy and *regulates* [MHC class II] expression in human skeletal muscle cells . Positive_regulation HLA-DRA TNF 20980264 2382334 Furthermore , *augmented* surface expression of [MHC class II] molecules in interferon-? ( IFN-? ) -treated myoblasts . Positive_regulation HLA-DRA TNF 20980264 2382338 These findings establish a mechanism through which *regulates* both macroautophagy and [MHC class II] expression and suggest that macroautophagy mediated antigen presentation contributes to the immunological environment of the inflamed human skeletal muscle . Positive_regulation HLA-DRA TNF 2125019 146699 *increased* IFN-G induced [MHC class II] expression . Positive_regulation HLA-DRA TNF 3139431 97391 The *role* of in the up-regulation as well as in the down-regulation of [MHC class II] expression in inflammatory processes is discussed . Positive_regulation HLA-DRA TNF 7489766 332306 In contrast to the parental U937 cell line , only , and not interferon (IFN)-gamma *induces* the expression of [MHC class II] antigens on C119/9 cells , and paradoxically , this induction was inhibited almost completely by IFN-gamma . Positive_regulation HLA-DRA TNF 7499872 336120 Studies with a neutralizing anti-TNF-alpha Ab , however , indicate that LPS augmentation of [MHC class II] did not *require* . Positive_regulation HLA-DRA TNF 9178691 434231 When added with 100 U/mL IFN-gamma , *enhanced* [MHC class II] and ICAM-1 expression on ISMCs and T-cell proliferation . Positive_regulation HLA-DRB1 CD14 15661814 1381989 Furthermore , the *upregulation* of CD80 , CD86 , [MHC class II] and interleukin-6 by ( + ) monocytes following activation with specific TLR ligands was decreased ( P < 0.05 ) in samples obtained following exercise compared with at rest . Positive_regulation HLA-DRB1 EPHB2 19786087 2209052 In addition , esculetin and HA14-1 mediated apoptosis was reduced by ERK inhibitors through inhibition of DR4 expression , suggesting that the synergistic effect was at least partially mediated through *dependent* induction of [DR4] expression . Positive_regulation HLA-DRB1 EPHB2 19786087 2209054 The results indicate that HA14-1 induced reversal of the anti-apoptotic effect of Bcl-2 confers apoptosis sensitivity to esculetin by a mitochondrial amplification step and through the *dependent* induction of [DR4] expression in U937/Bcl-2 cells . Positive_regulation HLA-DRB1 EPHB2 21044953 2357583 Thus , dependent , CHOP and Elk1 mediated mechanisms are *critical* for [DR5] induction . Positive_regulation HLA-DRB1 EPHB2 21078664 2371609 Overall , our results indicate that nimbolide can sensitize colon cancer cells to TRAIL induced apoptosis through three distinct mechanisms : reactive oxygen species- and *mediated* up-regulation of DR5 and [DR4] , down-regulation of cell survival proteins , and up-regulation of p53 and Bax . Positive_regulation HLA-DRB1 EPHB2 21167276 2396368 Piceatannol enhances TRAIL induced apoptosis in human leukemia THP-1 cells through Sp1- and *dependent* [DR5] up-regulation . Positive_regulation HLA-DRB1 EPHB2 21167276 2396373 In conclusion , our results suggest that PIC sensitizes TRAIL-induced-apoptosis via Sp1- and *dependent* [DR5] up-regulation . Positive_regulation HLA-DRB1 EPHB2 21817114 2490402 2-14 promoted *dependent* induction of [DR5] , thereby enhancing TRAIL mediated caspase-8 activation and apoptosis . Positive_regulation HLA-DRB1 EPHB2 22848091 2682380 In addition , we discovered that the phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2 and RSK2 were elevated after PS-341 treatment and inhibition of their phosphorylation using MAP-ERK kinase 1/2 inhibitor decreased the DR5 level , indicating that signaling is *involved* in [DR5] upregulation . Positive_regulation HLA-DRB1 EPHB2 23224239 2731476 Sub-toxic dose of apigenin sensitizes HepG2 cells to TRAIL through *dependent* up-regulation of TRAIL receptor [DR5] . Positive_regulation HLA-DRB1 EPHB2 23224239 2731478 Next , using pharmacological inhibitors , we found that activation is *involved* in the induction of [DR5] expression . Positive_regulation HLA-DRB1 EPHB2 23224239 2731481 Taken together , our results indicate that apigenin can enhance the apoptotic effect of TRAIL via *induced* up-regulation of [DR5] . Positive_regulation HLA-DRB1 EPHB2 24078627 2863346 Overall , this study indicates that azadirone can sensitize cancer cells to TRAIL through *mediated* up-regulation of DR5 and [DR4] signaling , down-regulation of cell survival proteins , and up-regulation of proapoptotic proteins . Positive_regulation HLA-DRB1 FAS 16462206 1522800 We report here that death receptor-5 (DR5) , tumor necrosis factor receptor-1 ( TNF-R1 ) , and are all located in the caveolin-1 enriched membrane fractions , and TRAIL *caused* the translocation of [DR5] , FasR , and TNF-R1 to the caveolar fractions . Positive_regulation HLA-DRB1 IL1B 1628893 191835 Among those cytokines , *had* a positive effect on IFN-gamma dependent induction of [MHC class II] genes . Positive_regulation HLA-DRB1 IL1B 8473727 216318 Simulating the effects of topically applied TNCB , intradermally injected ( but not IL-1 alpha or TNF alpha ) also *caused* enhancement of LC [MHC class II] expression . Positive_regulation HLA-DRB1 JAG1 12798309 1098750 The expression of [MHC class II] , CD86 , and CD83 Ags on DCs and CD40 ligand (L) associated IL-12 p70 production from DCs were *up-regulated* by the membrane . Positive_regulation HLA-DRB1 LBP 19265128 2045466 *up-regulated* DC expression of CD40 , CD80 , CD86 , and [MHC class II] molecules ; Positive_regulation HLA-DRB1 MAP2K6 15757891 1417040 Our study reveals that transformation of the colon cell line Caco-2 by Ki- and mainly by Ha-ras oncogenes sensitizes these cells to TRAIL induced apoptosis by causing specific *dependent* up-regulation of [DR4] and DR5 . Positive_regulation HLA-DRB1 PECAM1 11899433 894257 The results show that exposure to LPG did not affect the expression of major histocompatibility complex ( [MHC) class II] and B7 , but *induced* an up-regulation of CD25 , and vascular endothelial (VE)-cadherin expression and a down-regulation of Mac-1 expression , by LC . Positive_regulation HLA-DRB1 TLR7 17563917 1763071 ES , but not AWH , inhibited BMDC cytokine and chemokine production and co-stimulatory molecule expression ( CD40 , CD86 and [MHC class II] ) *induced* by ligation . Positive_regulation HLA-DRB1 TLR7 18802111 1964602 We also found that ligands , and to some extent TNF-alpha , were able to *increase* the expression of [MHC class II] and CD83 in endothelial cells , which might suggest a role for fish endothelial cells and TNF-alpha in Ag presentation . Positive_regulation HLA-DRB1 TNF 11914744 925317 alone did not induce MHC class II expression , but *enhanced* IFN gamma induced [MHC class II] expression . Positive_regulation HLA-DRB1 TNF 11914744 925325 IFN gamma and synergistically *induced* [MHC class II] expression on insulinoma cells through the induction of CIITA ; Positive_regulation HLA-DRB1 TNF 12067408 955030 CD34 expression was gradually lost , so that by day 9 , the majority of the cells were CD34 ( - ) /CMRF-44 ( + ) . GM-CSF and also *induced* CD40 expression , and up-regulation of CD54 and [MHC class II] on CD34 ( + ) cells ; Positive_regulation HLA-DRB1 TNF 12615723 1065493 Overexpression of a transdominant negative mutant of the inhibitory protein I kappa B alpha results in down-regulation of constitutively active NF-kappa B , *induction* of [DR5] , and 1-associated death domain expression and enhancement of TRAIL sensitivity . Positive_regulation HLA-DRB1 TNF 15502938 1342899 Involvement of receptor 1 and tumor necrosis factor related apoptosis *inducing* ligand- ( TRAIL ) [receptor-2/DR-5] , but not Fas , in graft injury in live-donor liver transplantation . Positive_regulation HLA-DRB1 TNF 16154304 1499439 Our results demonstrate that BM injected once ip in mice at 10 and 20 mg/kg increased the cellular influx to the peritoneal cavity , the [MHC class II] expression and the spreading ability , and also *induced* the production of NO , and H ( 2 ) O ( 2 ) . Positive_regulation HLA-DRB1 TNF 17646260 1829650 *Activation* of TNFR1 or [DR5] by or TRAIL may regulate osteoblast connectivity , which is important to bone turnover . Positive_regulation HLA-DRB1 TNF 18802111 1964601 We also found that TLR ligands , and to some extent , were able to *increase* the expression of [MHC class II] and CD83 in endothelial cells , which might suggest a role for fish endothelial cells and TNF-alpha in Ag presentation . Positive_regulation HLA-DRB1 TNF 19349211 2088722 In vitro , expression of TRAIL , DR4 and [DR5] on primary proximal tubular epithelial cells ( PTEC ) was *induced* by and IFNgamma . Positive_regulation HLA-DRB1 TNF 1981601 148640 [MHC class II] expression could not be *induced* with or IL-1 alone but required prolonged stimulation with IFN gamma . Positive_regulation HLA-DRB1 TNF 20980264 2382331 induces macroautophagy and *regulates* [MHC class II] expression in human skeletal muscle cells . Positive_regulation HLA-DRB1 TNF 20980264 2382335 Furthermore , *augmented* surface expression of [MHC class II] molecules in interferon-? ( IFN-? ) -treated myoblasts . Positive_regulation HLA-DRB1 TNF 20980264 2382339 These findings establish a mechanism through which *regulates* both macroautophagy and [MHC class II] expression and suggest that macroautophagy mediated antigen presentation contributes to the immunological environment of the inflamed human skeletal muscle . Positive_regulation HLA-DRB1 TNF 2125019 146701 *increased* IFN-G induced [MHC class II] expression . Positive_regulation HLA-DRB1 TNF 3139431 97392 The *role* of in the up-regulation as well as in the down-regulation of [MHC class II] expression in inflammatory processes is discussed . Positive_regulation HLA-DRB1 TNF 7489766 332307 In contrast to the parental U937 cell line , only , and not interferon (IFN)-gamma *induces* the expression of [MHC class II] antigens on C119/9 cells , and paradoxically , this induction was inhibited almost completely by IFN-gamma . Positive_regulation HLA-DRB1 TNF 7499872 336121 Studies with a neutralizing anti-TNF-alpha Ab , however , indicate that LPS augmentation of [MHC class II] did not *require* . Positive_regulation HLA-DRB1 TNF 9178691 434232 When added with 100 U/mL IFN-gamma , *enhanced* [MHC class II] and ICAM-1 expression on ISMCs and T-cell proliferation . Positive_regulation HLA-DRB1 TNF 9563466 500650 , a nongenotoxic cytokine , also *induced* the expression of [KILLER/DR5] in a number of cancer cell lines , irrespective of p53 status . Positive_regulation HLA-DRB1 TNFSF10 12207174 983504 Blockage of NFkappaB activation either by expression of dominant negative IkappaB or treatment with proteasome inhibitor lactacystin eliminates *induced* [DR5] expression . Positive_regulation HLA-DRB1 TNFSF10 12207174 983507 Thus , mediated NFkappaB activation *increases* [DR5] expression thereby amplifying the apoptotic response of TRAIL in epithelial derived cells . Positive_regulation HLA-DRB1 TNFSF10 12927928 1131931 Lamivudine treatment reduced *mediated* apoptosis and [TRAIL-R1/DR4] expression in Hep G2.2.15 cells . Positive_regulation HLA-DRB1 TNFSF10 14965271 1208865 ( TRAIL ) , also known as Apo2L , *activates* [DR4] and DR5 . Positive_regulation HLA-DRB1 TNFSF10 15256461 1272141 Several lung cancer cell lines express [DR4] and DR5 and undergo apoptosis in vitro in *response* to . Positive_regulation HLA-DRB1 TNFSF10 15385934 1324186 *induced* no discernible changes in FLIP , [DR4] , DR5 , Mcl-1 , or survivin expression , modest declines in levels of DcR2 and c-IAP , but resulted in the marked transcriptional downregulation of XIAP . Positive_regulation HLA-DRB1 TNFSF10 15389801 1354366 TRAIL-R1/death receptor (DR)4 and [TRAIL-R2/DR5] are members of the tumor necrosis factor (TNF) receptor family , and can be *activated* by the . Positive_regulation HLA-DRB1 TNFSF10 15536394 1336464 Expression of Fas , [DR4] , and DR5 is *detected* on the cell membrane of erythroblasts in all stages , whereas FasL and are present only in more mature erythroblasts . Positive_regulation HLA-DRB1 TNFSF10 15897906 1426801 HDAC inhibitors *synergized* with by inducing DRs DR4/TRAIL-R1 and [DR5/TRAIL-R2] through NFkappaB activation and some of the proapoptotic members of the Bcl-2 family , and engaging the mitochondrial pathway . Positive_regulation HLA-DRB1 TNFSF10 16247474 1518150 Interestingly , these effects were not dependent on *activation* of [DR5] by its ligand . Positive_regulation HLA-DRB1 TNFSF10 16462206 1522801 We report here that death receptor-5 (DR5) , tumor necrosis factor receptor-1 ( TNF-R1 ) , and Fas receptor (FasR) are all located in the caveolin-1 enriched membrane fractions , and *caused* the translocation of [DR5] , FasR , and TNF-R1 to the caveolar fractions . Positive_regulation HLA-DRB1 TNFSF10 16462206 1522803 Our results provide the first evidence for the caveolar localization of TNF-R1 and [DR5] and the coordinated redistribution among membrane fractions of several death receptors in *response* to . Positive_regulation HLA-DRB1 TNFSF10 17273769 1691725 Fenretinide up-regulates [DR5/TRAIL-R2] expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and *induces* synergistic apoptosis in colon cancer cell lines . Positive_regulation HLA-DRB1 TNFSF10 17645780 1780316 In contrast , NDGA neither enhanced *induced* apoptosis nor up-regulated [DR5] expression in normal peripheral blood mononuclear cells . Positive_regulation HLA-DRB1 TNFSF10 17646260 1829651 *Activation* of TNFR1 or [DR5] by TNF-alpha or may regulate osteoblast connectivity , which is important to bone turnover . Positive_regulation HLA-DRB1 TNFSF10 17666396 1793956 The mutant receptors also have a `` dominant negative '' effect whereby they inhibit the ability of to *induce* apoptosis through functional [DR4] receptors . Positive_regulation HLA-DRB1 TNFSF10 17909059 1803587 did not *increase* expression of [DR4/DR5] , or recruitment of procaspase-8 or FADD to the death inducing signaling complex (DISC) , but strikingly increased DISC associated procaspase-8 activation . Positive_regulation HLA-DRB1 TNFSF10 18165900 1869634 ARAP1 overexpressed in HEL cells does not affect their *induced* apoptosis or the membrane localization of [DR4] , but it enhances the cell-surface presentation of phosphatidyl serine . Positive_regulation HLA-DRB1 TNFSF10 18172319 1856013 In addition , As ( 2 ) O ( 3 ) -mediated up-regulation of CHOP and [DR5] , as well as partial proteolytic processing of procaspase-3 by , was not *induced* in astrocytes . Positive_regulation HLA-DRB1 TNFSF10 20354842 2260904 *activates* [DR4] and DR5 and thereby triggers apoptotic and non-apoptotic signaling pathways , but possible different roles of DR4 or DR5 in these responses has poorly been addressed so far . Positive_regulation HLA-DRB1 TNFSF10 20886583 2332080 Taken together , these studies show that a-TEA induces TRAIL/DR5 mitochondria dependent apoptosis in human breast cancer cells , and that *dependent* increases in [DR5] and decreases in c-FLIP expression are triggered by TRAIL or a-TEA treatments . Positive_regulation HLA-DRB1 TNFSF10 21115542 2383602 cell *mediated* activation of [TRAIL-R2/DR5] plays an important role during acute injury in NEMO ( ?hepa ) mice . Positive_regulation HLA-DRB1 TNFSF10 22948392 2734903 Additionally , HSP70 suppression inhibited the phosphorylation of ERK , AKT , and PKC , thereby downregulating c-FLIP-L. A549 xenografts in mice receiving HSP70 siRNA showed *induced* cell death and increased [DR4/DR5] levels and reduced tumor growth . Positive_regulation HLA-DRB1 TNFSF10 23224239 2731480 Inhibition of ERK1/2 by U0126 significantly decreased the *induced* [DR5] expression and apoptosis . Positive_regulation HLA-G CD14 24383466 2911961 Decidual ( + ) DC-SIGN ( + ) antigen presenting cells (APCs) *enhance* the [HLA-G] expression of cocultured CD4 ( + ) naïve T cells in vitro . Positive_regulation HLF CTGF 16141446 1499316 This study investigates the regulatory role of LXA4 on proliferation of [human lung fibroblasts (HLF)] *induced* by and mechanisms of LXA4 action . Positive_regulation HM13 SMN2 23897586 2915984 Furthermore , we demonstrate that IMP1 axonal localization depends on SMN levels , and that deficiency in SMA motor neurons *leads* to a dramatic reduction of [IMP1] protein levels . Positive_regulation HM13 SMN2 23897586 2915998 In contrast , no difference in IMP1 protein levels was detected in whole brain lysates from SMA mice , further suggesting neuron specific *roles* of in [IMP1] expression and localization . Positive_regulation HMGA2 EPHB2 11390395 842663 Together , our results demonstrate that mediated *induction* of [HMGI-C] is required to effectively repress GR/Dex stimulated transcription of alpha-ENaC gene and STAT3 mediated transactivation . Positive_regulation HMGB1 FAS 20565784 2285288 ( CD95 ) *induces* rapid , TLR4/IRAK4 dependent release of pro-inflammatory [HMGB1] from macrophages . Positive_regulation HMGB1 FAS 20565784 2285289 Both *induced* [HMGB1] release and associated pro-inflammatory cytokine production were significantly decreased from Tlr4-/- and Irak4-/- macrophages , but not Tlr2-/- macrophages . Positive_regulation HMGB1 FAS 20565784 2285291 We conclude that activation *induces* rapid , TLR4/IRAK4 dependent release of [HMGB1] that contributes to Fas mediated pro-inflammatory cytokine production by viable macrophages . Positive_regulation HMGB1 IL1B 17895302 1802743 [HMGB1] can *induce* expression of TNF-alpha and , and formation of a pro-inflammatory loop between HMGB1 , TNF-alpha , and IL-1beta may be responsible for the prolonged and sustained inflammation in CLE . Positive_regulation HMGB1 IL1B 20110250 2235649 stimulation of synoviocytes *increased* [HMGB1] expression , its translocation into the cytoplasm and secretion . Positive_regulation HMGB1 IL1B 20222144 2243572 Western blots confirmed that *induced* a release of [HMGB1] into astrocyte conditioned media . Positive_regulation HMGB1 IL1B 20222144 2243575 Blockade of *stimulated* [HMGB1] release with the ERK inhibitor U0126 was accompanied by a downregulation of CRM1 . Positive_regulation HMGB1 MAP2K6 21926646 2546831 6 *mediates* mechanical stretch induced [high-mobility group box 1] protein expression in pulmonary alveolar epithelial cells . Positive_regulation HMGB1 MAP2K6 21926646 2546845 The aim of this study was to explore the *role* of 6 ( MKK6 ) in the [HMGB1] expression in pulmonary alveolar epithelial cells induced by mechanical stretch . Positive_regulation HMGB1 TNF 12646658 1070261 Pharmacological suppression of activity with neutralizing Abs , or genetic disruption of TNF expression ( TNF knockout ) partially ( 50-60 % ) *inhibited* IFN-gamma mediated [HMGB1] release . Positive_regulation HMGB1 TNF 15502843 1327364 Nicotine , a selective cholinergic agonist , is more efficient than acetylcholine and inhibits [HMGB1] release *induced* by either endotoxin or . Positive_regulation HMGB1 TNF 16635351 1552724 ( 2 ) [HMGB1] could *induce* release in rat peritoneal macrophages , with peaking at 4 hours and decreasing at 8 hours later . Positive_regulation HMGB1 TNF 16980509 1673713 IFN-gamma already induced substantial HMGB1 secretion from the monocytic cell line RAW 264.7 within 24 h and even more so after 48 h . LPS only stimulated a modest HMGB1 release within 24 h , but this increased considerably by 48 h. *induced* [HMGB1] release was unexpectedly low . Positive_regulation HMGB1 TNF 17430886 1748900 Both full-length [HMGB1] and a truncated form of HMGB1 lacking the highly conserved glutamate-rich C-terminal tail can *induce* macrophage activation and production . Positive_regulation HMGB1 TNF 17617616 1769671 In this study , we demonstrate that increases in levels of a major stress-inducible protein , heat shock protein 72 ( Hsp72 ) by gene transfection attenuated LPS- or *induced* [HMGB1] cytoplasmic translocation and release . Positive_regulation HMGB1 TNF 17895302 1802742 [HMGB1] can *induce* expression of and IL-1beta , and formation of a pro-inflammatory loop between HMGB1 , TNF-alpha , and IL-1beta may be responsible for the prolonged and sustained inflammation in CLE . Positive_regulation HMGB1 TNF 18300566 1873438 Upon *stimulation* with lipopolysaccharides or , [HMGB1] is secreted from certain cells such as monocytes/macrophages and fosters inflammatory responses . Positive_regulation HMGB1 TNF 18346273 1925280 This suggests that is not the main *inducer* of extranuclear [HMGB1] during synovitis and that HMGB1 may represent a TNF independent molecule that could be considered as a possible target for future therapeutic intervention in RA . Positive_regulation HMGB1 TNF 18557992 1940721 In the previous issue of Arthritis Research & Therapy , Sundberg and colleagues address , for the first time in a prospective cohort study , whether [HMGB1] expression is *dependent* upon activity in patients with RA . Positive_regulation HMGB1 TNF 18582368 1941081 [HMGB1] is actively released from immune cells in *response* to ; Positive_regulation HMGB1 TNF 18713653 1974734 PACAP also suppressed [HMGB1] release *induced* by or IFN-gamma . Positive_regulation HMGB1 TNF 18953944 1982599 ( 100 ng/ml ) did not further *increase* the release of [HMGB1] in the monocytes from the patients with RA . Positive_regulation HMGB1 TNF 18953944 1982602 *induces* the release and cytoplasmic translocation of [HMGB1] in the peripheral blood monocytes of RA patients and thalidomide inhibits the release and translocation of HMGB1 . Positive_regulation HMGB1 TNF 20659415 2310972 stimulation of chondrocytes *caused* translocation of [HMGB-1] from the nucleus to the cytoplasm . Positive_regulation HMGB1 TNF 21186276 2396760 surprisingly , [HMGB1] itself did not *induce* myocyte production . Positive_regulation HMGB1 TNF 21406085 2404547 In HepG2 cell culture , LPS or actively *induced* [HMGB1] cytoplasmic translocation and release in a time- and dose dependent fashion . Positive_regulation HMGB1 TNF 22154216 2536493 *induced* secretion of [HMGB1] from non-immune canine mammary epithelial cells ( MTH53A ) . Positive_regulation HMGB1 TNF 23146691 2729593 EG was found to suppress the release of HMGB1 , the production of , and the *activation* of nuclear factor-?B ( NF-?B ) by [HMGB1] in HUVECs , and to inhibit HMGB1 mediated hyperpermeability and leukocyte migration in mice . Positive_regulation HMGB1 TNF 24184598 2889904 In addition , GCLs suppressed the production of and interleukin 6 and *activation* of nuclear factor-?B and extracellular regulated kinases 1/2 by [HMGB1] . Positive_regulation HMGB1 TNFSF10 16968820 1673503 treatment , however , *induced* [HMGB1] release , and it is interesting that this extrinsic pathway mediated cell death was blocked with the pancaspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone . Positive_regulation HMGCR TNF 16941280 1609433 Although Pg and E. coli LPS had no effect on HMG-CoA reductase gene expression , both and interleukin-6 (IL-6) , especially IL-6 at low concentration , markedly *up-regulated* [HMG-CoA reductase] gene expression . Positive_regulation HMGCR TNF 7948424 277273 or IL-1 *increased* hepatic [HMG CoA reductase] mRNA levels by 3.5- and 3-fold , respectively . Positive_regulation HMGCR TNF 7948424 277275 + IL-1 *increased* [HMG CoA reductase] mRNA levels by 7-fold . Positive_regulation HMGCR TNF 8477669 218548 Moreover , and IL-1 produced a 2.3- and 2.1-fold *increase* in hepatic [HMG-CoA reductase] activity , respectively . Positive_regulation HMGN1 IL1B 9880529 583976 *Induction* of [high mobility group-I] ( Y ) protein by endotoxin and in vascular smooth muscle cells . Positive_regulation HMGN2 IL1B 9880529 583977 *Induction* of [high mobility group-I] ( Y ) protein by endotoxin and in vascular smooth muscle cells . Positive_regulation HMGN3 IL1B 9880529 583975 *Induction* of [high mobility group-I] ( Y ) protein by endotoxin and in vascular smooth muscle cells . Positive_regulation HMGN4 IL1B 9880529 583978 *Induction* of [high mobility group-I] ( Y ) protein by endotoxin and in vascular smooth muscle cells . Positive_regulation HMGN5 IL1B 9880529 583979 *Induction* of [high mobility group-I] ( Y ) protein by endotoxin and in vascular smooth muscle cells . Positive_regulation HMOX1 ALOX5 19744468 2183319 The combinations were also found to suppress iNOS , COX-2 , <5-lipoxygenase (5-LOX)> and cPLA(2) but *induce* [HO-1] . Positive_regulation HMOX1 ARSA 18215658 1863970 Colonic [HO-1] protein expression , determined by Western blot analysis in this colitis model , was likewise further *induced* by <5-ASA> . Positive_regulation HMOX1 ARSA 20844928 2375376 Following previous findings that cadmium ( Cd ) induces heme oxygenase-1 (HO1) gene expression in alfalfa seedling roots , we now show that the decreased glutathione ( GSH ) and contents , *induction* of [HO-1] gene expression and its protein level by Cd was mimicked by a GSH depletor diethylmaleate ( DEM ) . Positive_regulation HMOX1 BLVRA 21099244 2383378 Additionally , depletion of *reduced* the H2O2 dependent induction of [heme oxygenase-1 (HO-1)] in young HDFs , but not in senescent cells , suggesting an aging dependent differential modulation of responses to oxidative stress . Positive_regulation HMOX1 CD14 24651442 2925941 We showed that [HO-1] and CO *induced* expression and efficiently increased expansion and differentiation of myeloid cells into macrophages . Positive_regulation HMOX1 EDN2 15567344 1343786 *mediated* induction of [heme oxygenase-1] in the spinal cord is attenuated in transgenic mice overexpressing superoxide dismutase . Positive_regulation HMOX1 EPHB2 12225959 987936 We also demonstrate that [HO-1] gene transcription after A-R *involves* , JNK , and p38 MAPK pathways . Positive_regulation HMOX1 EPHB2 14647439 1188316 The levels of [HO-1] and p21 induced were significantly *inhibited* by p38 mitogen activated protein kinase ( p38 MAPK ) inhibitor ( SB203580 ) and inhibitor ( PD098059 ) . Positive_regulation HMOX1 EPHB2 14998722 1216707 Although 15d-PGJ ( 2 ) significantly activated the MAPKs of JNK and ERK , the activation of JNK and did not *contribute* to the induction of [HO-1] as determined using transfection of dominant negative plasmids and MAPKs inhibitors . Positive_regulation HMOX1 EPHB2 15993334 1429658 Whereas inhibiting the ERK pathway with the MEK inhibitor PD98059 significantly decreased HNE mediated phosphorylation , c-Fos protein induction , AP-1 binding , and [HO-1] protein *induction* , inhibition of the ERK pathway had no effect on HNE induced HO-1 mRNA . Positive_regulation HMOX1 EPHB2 15993334 1429663 This suggests that is *involved* in the increase in [HO-1] through regulation of translation rather than transcription . Positive_regulation HMOX1 EPHB2 16651638 1558225 Inhibition of activation with MEK inhibitors ( PD98059 or U0126 ) *diminished* induction of the antioxidant enzyme [heme oxygenase-1] . Positive_regulation HMOX1 EPHB2 16928811 1603907 Activation of and JNK signaling also *resulted* in the elevation of ARE activity and [HO-1] expression . Positive_regulation HMOX1 EPHB2 17196236 1695500 These findings suggest that the activation is *necessary* but not sufficient for optimal arsenite stimulated [HO-1] induction . Positive_regulation HMOX1 EPHB2 18554677 1959062 In this study , we demonstrate that MT-III prevents the accumulation of reactive oxygen species ( ROS ) in dopaminergic SH-SY5Y cells challenged with the Parkinson 's disease related neurotoxin 6-hydroxydopamine ( 6-OHDA ) by a mechanism that involves phosphatidylinositol 3-kinase (PI3K) and kinase/NF-E2 related factor 2 (Nrf2) dependent *induction* of the stress response protein [heme oxygenase-1 (HO-1)] . Positive_regulation HMOX1 EPHB2 19628634 2137824 Phosphorylation of and Nrf2 , activation and nuclear translocation of Nrf2 , and oxidation of Keap1 are all *involved* in the lansoprazole induced [HO-1] up-regulation . Positive_regulation HMOX1 EPHB2 19822148 2159854 These results suggest that ( 1/2 ) and JNK are *involved* in CS-induced biphasic [HO-1] expression by a specific regulation of Nrf2/Keap1-Bach1 . Positive_regulation HMOX1 EPHB2 19833168 2196367 The pharmacological inhibition of and p38 MAPK *inhibited* rottlerin induced [HO-1] up-regulation . Positive_regulation HMOX1 EPHB2 19931411 2203800 and phosphatidylinositol 3-kinase (PI3K)/protein kinase B ( PKB , Akt ) *contributed* to ARE-driven [HO-1] expression . Positive_regulation HMOX1 EPHB2 20302373 2238033 Neurotrophic and cytoprotective action of luteolin in PC12 cells through *dependent* induction of Nrf2-driven [HO-1] expression . Positive_regulation HMOX1 EPHB2 20668435 2317134 In addition , DHA caused AKT and ERK activation in a time dependent manner , and the DHA induced [HO-1] upregulation could be *attenuated* by PI-3 kinase/AKT and inhibitors . Positive_regulation HMOX1 EPHB2 21366594 2415859 The H ( 2 ) O ( 2 ) -induced [HO-1] induction was Akt- and *dependent* . Positive_regulation HMOX1 EPHB2 22056766 2534101 These results indicated that was *required* to induce [HO-1] expression in rat hepatocytes . Positive_regulation HMOX1 EPHB2 22144097 2617249 Ampelopsin inhibits H2O2 induced apoptosis by and Akt signaling pathways and *up-regulation* of [heme oxygenase-1] . Positive_regulation HMOX1 EPHB2 23073806 2690055 Moreover , ß-PGG *induced* Nrf2 nuclear translocation , which was found to be upstream of ß-PGG induced HO-1 expression , and the activation of and Akt , a pathway that is involved in ß-PGG induced Nrf2 nuclear translocation , [HO-1] expression and neuroprotection . Positive_regulation HMOX1 EPHB2 23261939 2763844 Akt and are *involved* in [HO-1] induction after oxidative stress . Positive_regulation HMOX1 EPHB2 24503931 2914143 DHF activated extracellular regulated kinase (ERK) and protein kinase B ( PKB , Akt ) in keratinocytes , while the and Akt inhibitors *attenuated* DHF enhanced Nrf2 and [HO-1] expression . Positive_regulation HMOX1 EPHB2 25159204 2957467 Treatment of orbital fibroblasts with TanIIA increased phosphorylated extracellular signal regulated kinase ( pERK ) , and an inhibitor significantly *blocked* TanIIA induced [HO-1] upregulation . Positive_regulation HMOX1 F2R 22541814 2669209 Pharmacologic inhibitors or activators and genetic inhibition by siRNA of protease activated receptors (PARs) revealed that the and PAR3 receptors , but not the PAR4 receptor , are *involved* in thrombin mediated upregulation of [HO-1] . Positive_regulation HMOX1 FOXO1 24255720 2869492 Cobalt protoporphyrin induces [HO-1] expression *mediated* partially by and reduces mitochondria derived reactive oxygen species production . Positive_regulation HMOX1 FOXO1 24255720 2869493 Previous study showed that *induces* [HO-1] expression by binding to HO-1 promoter . Positive_regulation HMOX1 FOXO1 24255720 2869494 The question whether cobalt protoporphyrin induces [HO-1] expression *mediated* by and subsequently lessens reactive oxygen species production remains to be elucidated . Positive_regulation HMOX1 FOXO1 24255720 2869496 Cobalt protoporphyrin induces [HO-1] and other oxidative stress-responsive genes expression *mediated* partially by , and has an important role in reducing cellular reactive oxygen species level . Positive_regulation HMOX1 FOXO1 24269680 2893041 drastically increased in atrophied muscle and selectively *stimulated* [HO-1] gene transcription through direct DNA binding . Positive_regulation HMOX1 FOXO1 24269680 2893042 Collectively , [HO-1] *induced* by may cause skeletal muscle atrophy . Positive_regulation HMOX1 GPR115 16476737 1548400 In this study we investigated whether the oncogenic ( KSHV-GPCR or vGPCR ) , one of the key KSHV genes involved in KS development , *activated* [HO-1] expression . Positive_regulation HMOX1 GPR132 16476737 1548389 In this study we investigated whether the oncogenic ( KSHV-GPCR or vGPCR ) , one of the key KSHV genes involved in KS development , *activated* [HO-1] expression . Positive_regulation HMOX1 GPR87 16476737 1548469 In this study we investigated whether the oncogenic ( KSHV-GPCR or vGPCR ) , one of the key KSHV genes involved in KS development , *activated* [HO-1] expression . Positive_regulation HMOX1 IL1B 10823822 714878 An inhibitor of TRX reductase , used to prevent TRX translocation in the reduced state , decreased [HO-1] *induction* by and LPS . Positive_regulation HMOX1 IL1B 20110250 2235648 Induction of [HO-1] by CoPP in the *presence* of decreased the expression of MMP-1 and -3 , and MMP activity . Positive_regulation HMOX1 IL1B 7626076 316230 We have evaluated the regulation of [heme oxygenase-1] mRNA *induction* by the inflammatory stimuli , phorbol 12,13-myristate acetate , heat shock and in cultured rat mesangial cells . Positive_regulation HMOX1 IL1B 7626076 316232 These data suggest that pro-inflammatory stimuli increase heme oxygenase-1 mRNA expression in rat mesangial cells and that *induced* [heme oxygenase-1] mRNA level is negatively modulated by PGE2 . Positive_regulation HMOX1 IL1B 9751495 533557 After a 20-h culture , there was a small increase in [HO-1] in control islets , and *induced* HO-1 expression above control levels . Positive_regulation HMOX1 IL1B 9751495 533559 N ( G ) -monomethyl-L-arginine inhibited the *induced* increase in [HO-1] . Positive_regulation HMOX1 MAP2K6 15964514 1423274 Inhibitors of protein kinase C ( PKC ) or mitogen activated protein kinases (MAPK) p38 ( MAPK ) and or c-jun-NH2-terminal kinase ( JNK ) significantly *attenuated* induction of [HO-1] . Positive_regulation HMOX1 MAP2K6 19336889 2052907 Eupatilin induced [HO-1] expression and Nrf2 were partly *attenuated* by inhibitor PD98059 and almost completely by phosphatidyl-inactiol 3 kinase (PI3K) inhibitor LY294002 , but not by c-Jun N-terminal kinase (JNK) inhibitor SP600125 or p38 mitogen activated protein kinase (MAPK) inhibitor SB202190 . Positive_regulation HMOX1 MAP2K6 20668435 2317140 In addition , DHA caused AKT and ERK activation in a time dependent manner , and the DHA induced [HO-1] upregulation could be *attenuated* by PI-3 kinase/AKT and inhibitors . Positive_regulation HMOX1 SRGN 17112409 1645598 at 10 mmol/L increased the HbCO level in the medium following 18 h treatment and *increased* [HO-1] expression by the ASMC following 12 h treatment . Positive_regulation HMOX1 TLR7 21677132 2451325 Bruton 's tyrosine kinase is required for *dependent* [heme oxygenase-1] gene activation via Nrf2 in macrophages . Positive_regulation HMOX1 TNF 10330231 614321 and IL-1alpha *induce* [heme oxygenase-1] via protein kinase C , Ca2+ , and phospholipase A2 in endothelial cells . Positive_regulation HMOX1 TNF 12056510 951860 did not affect TNFR-1 expression in the liver and *resulted* in time dependent up-regulation of iNOS , IL-1beta and [HO-1] . Positive_regulation HMOX1 TNF 12918124 1130795 LPS induced [HO-1] expression is mainly *mediated* by endogenous , but only partially by endogenous IL-1beta . Positive_regulation HMOX1 TNF 15319486 1303766 These results show that DEP , through eDEP mediated ROS , *induce* [HO-1] expression and IL-10 production and at the same time inhibit AM production of and IL-12 to dampen the host immune responses . Positive_regulation HMOX1 TNF 15650392 1364028 In contrast , hemin and hemoglobin , but neither nor H2O2 , *caused* efficient [HO-1] expression . Positive_regulation HMOX1 TNF 15953572 1421769 Moreover , co-stimulation of PRL with LPS caused activation of HMMs functions , enhancement of HO-1 expression and induction of VEGF release , whereas addition of PRL inhibited up-regulation of [HO-1] or VEGF *induced* by IFN-gamma or . Positive_regulation HMOX1 TNF 16822952 1625236 did not *induce* [HO-1] expression in CMVEC . Positive_regulation HMOX1 TNF 18202225 1883779 Further investigation revealed that the cytoprotective gene [heme oxygenase-1 (HO-1)] was induced in NF-kappaB inhibited AML cells in *response* to stimulation , and HO-1 was responsible for the resistance of AML cells to the cytotoxic actions of TNF . Positive_regulation HMOX1 TNF 18242889 1865001 In conclusion , reactive oxygen species ( ROS ) , rather than or nitric oxide ( NO ) , are *involved* in LPS induced upregulation of [HO-1] in fetal liver . Positive_regulation HMOX1 TNF 19360326 2058303 We demonstrated inhibition of *induced* gene expression and release of IL-8 and [HO-1] in human monocytic THP-1 cells exposed to both volatile anesthetics . Positive_regulation HMOX1 TNF 20193368 2180888 Pretreatment with alpha-ZAL and p47(phox) siRNA both attenuated *induced* [HO-1] protein expression . Positive_regulation HMOX1 TNF 21116791 2350931 Interestingly , pretreatment with SFN result in significantly suppressed IFN-? and *induced* TARC/CCL17 and MDC/CCL22 production through the induction of [HO-1] . Positive_regulation HMOX1 TNF 21307400 2359997 Here we show for the first time that the modulatory protein , FLICE-inhibitory protein (FLIP) indirectly regulates induction of [HO-1] in *response* to in human AML blasts , but not non-cancerous control cells . Positive_regulation HMOX1 TNF 22155307 2531178 [HO-1] induction significantly reduced the expression of matrix metalloproteinase (MMP)-1 , MMP-2 and MMP-3 , and the production of pro-inflammatory cytokines such as and IL-6 whereas IL-10 levels *increased* . Positive_regulation HMOX1 TNF 22553400 2590577 Serum alanine aminotransferase , aspartate transaminase , and interleukin-6 levels *increased* in the HO-1 siRNA and [HO-1] siRNA + DZ groups , and decreased in the DZ group . Positive_regulation HNF1A TNF 21791562 2467554 In situ hybridization analysis has confirmed the differential expression of three of these genes , namely *induced* protein 6 , gonadotropin-inducible [transcription factor 1] , and ornithine decarboxylase antizyme inhibitor 1 . Positive_regulation HNF1B IL1B 17021248 1674242 Finally , *caused* concentration related up-regulation of [vHNF-1C] mRNA levels and increased binding of vHNF-1C protein to the HRE , whereas HNF-1alpha-HRE complex formation was reduced . Positive_regulation HNF1B NR2F1 8622679 354488 The [vHNF1] promoter is *transactivated* by and COUP-TFII/Arp1 and , unlike the HNF1 promoter , is virtually unaffected by HNF4 . Positive_regulation HNF1B NR2F1 8622679 354490 Interestingly , the proximal octamer site and not the DR-1 site is required for and COUP-TFII/Arp1 *transactivation* of the [vHNF1] promoter . Positive_regulation HNF1B NR2F1 8622679 354492 We present evidence of an interaction between COUP-TFI/Ear3 and the octamer binding proteins in vitro and in the cell , suggesting that and COUP-TFII *activate* the [vHNF1] promoter via an indirect mechanism . Positive_regulation HNF4A FOXA1 23318274 2746703 We conclude that human FABP1 has a complex mechanism of regulation where C/EBPa displaces [HNF4a] and hampers *activation* by and PPARa . Positive_regulation HNF4A IL1B 11679969 873811 *resulted* in a decrease in [HNF-4 alpha] levels in HepG2 cells . Positive_regulation HNF4A IL1B 16351573 1519283 Our results indicate that p38 kinase mediated Ser158 phosphorylation is essential for augmentation of the DNA binding and transactivation potential of [HNF4alpha] in the *presence* of . Positive_regulation HNF4A PGC 15322103 1303795 The coactivator *enhanced* transcriptional activity of [HNF-4] , and this enhancement was suppressed by rifampicin activated PXR . Positive_regulation HNF4A PGC 20953676 2375972 Additionally , *stimulates* the [SREBP2/HNF4a-] and PPARa/RXRa mediated transactivation of human NPC1L1 . Positive_regulation HNF4A UGT1A7 20406851 2274179 In contrast to liver expressed UGT1A9 , transcriptional *activation* of by [HNF4alpha] was lower and dependent on higher HNF4alpha concentrations , which may contribute to the observed differences in tissue expression patterns . Positive_regulation HNMT IL1B 8653552 343047 Simultaneously *increased* activity of HDC and [histamine-N-methyltransferase (HMT)] , a neuronal histamine catabolizing enzyme . Positive_regulation HNMT IL1B 9933502 589430 *increased* the activities of both histidine decarboxylase (HDC) , an HA synthesizing enzyme , and [HA-N-methyltransferase (HMT)] , an HA catabolizing enzyme . Positive_regulation HNRNPC IL1B 16847181 1588137 The messenger RNA expressions of [LARC] ( liver and activation regulated chemokine ) , GMCSF ( granulocyte-macrophage colony stimulating factor ) , epiregulin , ICAM1 ( intercellular adhesion molecule 1 ) , and TGFA ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation HNRNPD TNF 12040173 949658 A common feature of each pathway is the *induced* formation of a [multiprotein] signaling complex at the cell membrane . Positive_regulation HNRNPF CCL17 12909129 1121889 Endogenous CCL17 and B7-DC mRNAs were increased similarly in IL-4 cultured [DCs] but only was *induced* by LPS . Positive_regulation HNRNPF CD14 9680340 521000 Cultures enriched in *dependent* [DCs] were more potent stimulators of a mixed leukocyte reaction , compared with control GTS cultures containing both types of DCs . Positive_regulation HNRNPF CD14 9680340 521008 When exposed to the appropriate cytokine combinations , these cells yielded granulocytes , monocytes , and *dependent* [DCs] . Positive_regulation HNRNPF CD14 9680340 521012 Although TNF is required to ensure the institution of DC hematopoiesis from CD34 ( + ) progenitor cells , its activity on a later progenitor appears to limit the development of *dependent* [DCs] . Positive_regulation HNRNPF EDN2 15528350 1332538 Additionally , and hPR also *induced* phenotypic and functional maturation [DCs] . Positive_regulation HNRNPF EDN2 18195069 1857027 Here , we report that can *activate* myeloid [DCs] by triggering the Toll-like receptor (TLR)2-myeloid differentiation factor 88 signaling pathway , thus establishing EDN as an endogenous ligand of TLR2 . Positive_regulation HNRNPF EPHB2 20967853 2369597 Selective activation *induced* mouse and human [DCs] to secrete bioactive transforming growth factor ß , a process required for suppression of T cell responses and differentiation of antigen-specific Treg cells . Positive_regulation HNRNPF FAS 10756053 682846 In this study , human monocyte derived [DCs] were used to demonstrate that DC apoptosis in MV-infected DC-T-cell cocultures is *mediated* , whereas apoptotic T cells could not be rescued by blocking the Fas pathway . Positive_regulation HNRNPF FAS 10756053 682856 A model is proposed to explain how both a specific immune response and immunosuppression can simultaneously occur after MV infection through *mediated* apoptosis and CD40 activation of [DCs] . Positive_regulation HNRNPF FAS 11104808 756542 *activated* [DCs] upregulate the expression of the major histocompatibility complex class II , B7 , and DC-lysosome associated membrane protein ( DC-LAMP ) molecules and secrete proinflammatory cytokines , in particular interleukin (IL)-1beta and tumor necrosis factor alpha . Positive_regulation HNRNPF FAS 23943615 2845259 Here , we show that CD11b ( hi ) Ia ( low ) regulatory [DCs] expressed high level of Fas , and endothelial stromal cell derived TGF-ß could *induce* high expression of on regulatory DCs via ERK activation . Positive_regulation HNRNPF FAS 23943615 2845268 ligation could *promote* regulatory [DCs] to inhibit CD4 ( + ) T cell proliferation more significantly . Positive_regulation HNRNPF FAS 23943615 2845276 Furthermore , ligation preferentially *induced* regulatory [DCs] to produce IL-10 and IP-10 via ERK mediated inactivation of GSK-3 and subsequent up-regulation of ß-catenin . Positive_regulation HNRNPF IL1B 14666382 1242531 Monocyte derived [DCs] were generated in a culture of monocyte with interleukin 4 (IL-4) and granulocyte-macrophage colony stimulating factor , and the maturation of DCs was *induced* by either lipopolysaccharide (LPS) or a proinflammatory cytokine cocktail : tumor-necrosis factor alpha , prostaglandin E2 , IL-6 , and . Positive_regulation HNRNPF IL1B 15560757 1341029 *Stimulation* of day 8 [DCs] from AD patients with TNF-alpha and enhanced the expression of CD83 and CD86 and restored the production of IL-16 . Positive_regulation HNRNPF IL1B 20386470 2245248 LPS stimulation of [DCs] *induced* IL-10 , IL-12p70 , TNFalpha and secretion , and taxol pretreatment modified this response by down regulating IL-1beta secretion whereas colchicine induced a proinflammatory cytokine profile with reduced IL-10 and increased IL-12p70 and TNFalpha secretion . Positive_regulation HNRNPF ITGB2 19234188 2040157 Taken together , one of the mechanisms of Treg mediated suppression functions across species and mediates an *dependent* interaction between Tregs and [DCs] . Positive_regulation HNRNPF ITGB2 23817428 2815790 Therefore , our results indicate that *dependent* interactions between T cells and [DCs] play a crucial role not only in supporting firm arrest during Ag recognition but also in facilitating the Ag scanning processes . Positive_regulation HNRNPF JAG1 19003206 1184959 Our results show that orally administered *induce* systemic T cell unresponsiveness through splenic [DCs] without inducing cell division of T cells , thus providing evidence that splenic DCs are involved in oral tolerance induction . Positive_regulation HNRNPF MAP2K6 24670797 2934960 Our previous research demonstrates that *activation* of [dendritic cells (DCs)] through is required for Ni-induced allergy in mice . Positive_regulation HNRNPF S1PR3 20826749 2325214 Thus , in vitro generated [DCs] *require* S1P(1) and to accomplish this , whereas skin derived DCs migrate unhindered in the absence of S1P(3) but not when S1P(1) signaling is blocked . Positive_regulation HNRNPF TCN1 24296809 2921396 Functionally , OK-432 plus IFN-? conditioned [DCs] *induce* remarkable Th1 and responses more effectively than OK-432 alone , even more than the use of a-type-1 cytokine cocktail . Positive_regulation HNRNPF TLR7 12515817 1039211 Polarized Th1 responses resulting from high antigen dose were not additionally enhanced by *stimulation* of [DCs] by ligands . Positive_regulation HNRNPF TLR7 12682240 1077627 We hypothesized that microbial ligands could *activate* [DCs] to cross-present Ag to CTLs . Positive_regulation HNRNPF TLR7 12776992 1095449 Each can *activate* [DCs] in a similar , but distinct manner . Positive_regulation HNRNPF TLR7 15585847 1345789 Thus , proinflammatory cytokines produced by *activated* , mature [DCs] are required for reversal of Treg anergy , but are not required to overcome Treg suppression . Positive_regulation HNRNPF TLR7 15597784 1346521 We demonstrate that SOCS1 and SOCS3 *play* an important regulatory role in macrophages and [dendritic cells (DCs)] by modulating signaling . Positive_regulation HNRNPF TLR7 15995707 1434798 Synergic stimulation increased production of interleukins 12 and 23 and *increased* the Delta-4/Jagged-1 ratio , leading to [DCs] with enhanced and sustained T helper type 1-polarizing capacity . Positive_regulation HNRNPF TLR7 16219795 1508098 Interleukin-12 (IL-12) is a heterodimeric cytokine produced by [dendritic cells (DCs)] in *response* to ligation . Positive_regulation HNRNPF TLR7 17041145 1649339 In conclusion , we demonstrate that the anti-microbial peptide LL-37 inhibits the *activation* of [DCs] by ligands . Positive_regulation HNRNPF TLR7 17218388 1724858 In our study we demonstrate that *stimulation* of monocyte derived [DCs] with ligands differentially affects the uptake and cross-presentation of cellular antigens . Positive_regulation HNRNPF TLR7 17237413 1689902 In this study we demonstrate that the ability of *activated* [DCs] to suppress Th2 cell development is Ag dose independent and unique to DCs that have been activated through TLRs vs by cytokines . Positive_regulation HNRNPF TLR7 17237413 1689946 We show that *activated* [DCs] inhibit early IL-4 production by CD4 T cells and thus inhibit their ability to subsequently increase GATA-3 expression and commit to the Th2 lineage . Positive_regulation HNRNPF TLR7 17238832 1664260 Further , Stat3 was phosphorylated and bound to the IL-10 promoter in *stimulated* [DCs] . Positive_regulation HNRNPF TLR7 17414322 1722516 Together , our data suggest that ligands *induce* the generation of mature [DCs] that integrate migratory and cytokine secretory capacity as well as cytotoxic T lymphocyte ( CTL ) stimulatory properties . Positive_regulation HNRNPF TLR7 17430585 1728919 ligand stimulation *induced* [DCs] capable of secreting IL-12p70 in primary cultures and after one day of coculture with CD40L expressing fibroblasts , mimicking an encounter with T cells . Positive_regulation HNRNPF TLR7 17508961 1745087 Activation of TLRs by administration of specific bacterial ligands , in particular lipopolysaccharide , can augment airway sensitization in mice , and there is evidence that this process involves *dependent* activation of [DCs] . Positive_regulation HNRNPF TLR7 17548596 1752149 Produced by [dendritic cells (DCs)] in *response* to ligands , IL-27 recently emerged as a key regulator of inflammatory responses . Positive_regulation HNRNPF TLR7 17848994 1795786 *mediated* activation of [dendritic cells (DCs)] is known to be a critical event in the initiation of cellular and humoral immune responses . Positive_regulation HNRNPF TLR7 18259609 1877390 A prerequisite for strong adaptive antiviral immunity is the robust initial activation of the innate immune system , which is frequently mediated by *activated* plasmacytoid [DCs] ( pDCs ) . Positive_regulation HNRNPF TLR7 18424745 1899964 Furthermore , T. gondii activated plasmacytoid [DCs] produce high levels of IL-12 and both plasmacytoid DC maturation and cytokine production are *dependent* on . Positive_regulation HNRNPF TLR7 19017945 1991911 In these ways , *activated* [DCs] are able to activate naive Th cells and initiate Th1 and Th17 responses , and TLR ligands thus serve as adjuvants for these types of responses . Positive_regulation HNRNPF TLR7 19164127 2048389 We also showed that the Jak/STAT signaling pathway was involved in CD40 expression and cytokine production in *stimulated* [DCs] but negatively regulated CD83 expression and cytokine secretion in DCs activated through TLR8 . Positive_regulation HNRNPF TLR7 19255934 2175720 The aim of our study was to determine whether *mediated* stimulation of monocytes and [dendritic cells (DCs)] contributes to the higher levels of CCL18 in SSc . Positive_regulation HNRNPF TLR7 19625644 2118363 We have investigated the ability of *stimulated* human Langerhans cells ( LC ) , dermal DCs (dDC) , and monocyte derived [DCs] ( moDC ) to affect naive and memory Th17 and Th1 responses . Positive_regulation HNRNPF TLR7 19625644 2118403 *stimulated* [DCs] were capable of inducing IL-17A and IFN-gamma production from memory T cells , although the mechanism used by each DC subset differed . Positive_regulation HNRNPF TLR7 19836139 2196397 Additionally , saliva treated [DCs] also presented a similar pattern of cytokine modulation in *response* to other ligands . Positive_regulation HNRNPF TLR7 19854106 2203253 Here , we demonstrate that several ligands , particularly LPS and a synthetic lipoprotein , *activate* human [DCs] to direct increased human Th17 differentiation . Positive_regulation HNRNPF TLR7 20200270 2229546 In *response* to signaling , conventional [DCs] can also produce IFN-beta but not IFN-alpha in a type I IFN independent manner . Positive_regulation HNRNPF TLR7 20361966 2282007 TcES with chemically altered glycans failed to modulate mediated *activation* of [DCs] and their Th1-inhibitng ability , which was STAT6 independent . Positive_regulation HNRNPF TLR7 20451253 2275253 However , down-modulation of chemokine production was observed in simultaneously *stimulated* [DCs] . Positive_regulation HNRNPF TLR7 20498209 2289091 Systemic sclerosis ( SSc ) is an autoimmune disease and accumulating evidence suggests a role for *mediated* activation of [dendritic cells (DCs)] . Positive_regulation HNRNPF TLR7 20498209 2289151 The altered mediated *activation* of [DCs] may be responsible for Th2 skewed T-cell activation in SSc that may be orchestrated by fibrogenic T-cell cytokines , such as IL-4 and IL-13 . Positive_regulation HNRNPF TLR7 20547386 2295863 Collectively , these results demonstrate that dsRNA activated DCs induce more highly polarized human Th1 responses than the other ligand *activated* [DCs] tested here . Positive_regulation HNRNPF TLR7 21469103 2422736 In the presence of *activated* splenic [DCs] , Foxp3 was transiently induced in naïve T cells by TGF-ß but was downregulated at later time points . Positive_regulation HNRNPF TLR7 21493800 2444174 These results suggest that TLR4 and signals together *induce* [DCs] with fully mature and less mature phenotypes that are both required to more efficiently prime CD8+ T cells with qualities associated with memory T cells . Positive_regulation HNRNPF TLR7 21690322 2455610 DCs are important primary targets of TSLP , and we unexpectedly demonstrated that [DCs] also produce TSLP in *response* to stimulation and that this is augmented by IL-4 . Positive_regulation HNRNPF TLR7 21711348 2460680 In this study , we attempted to determine whether AIMP1 is capable of regulating the expression of TLRs , and also capable of affecting the *mediated* activation of [DCs] . Positive_regulation HNRNPF TLR7 22482518 2589155 Our data show that soluble products of T. suis , S. mansoni and T. spiralis suppress TNF-a and IL-12 secretion by *activated* human [DCs] , and that T. suis and S. mansoni , but not T. spiralis , strongly enhance expression of OX40L . Positive_regulation HNRNPF TLR7 22534476 2618628 *activated* conventional [DCs] promote ?-secretase mediated conditioning of plasmacytoid DCs . Positive_regulation HNRNPF TLR7 22753939 2627314 We demonstrate that concurrent Notch and stimulation results in a unique cytokine profile in mouse bone-marrow *derived* [DCs] characterized by enhanced IL-10 and IL-2 , and reduced IL-12 expression compared with TLR ligation alone . Positive_regulation HNRNPF TLR7 22777000 2719468 Synergistic *activated* [DCs] were also able to induce lymphocytes possessing the specific cytotoxicity against MC38-CEA cells in vitro . Positive_regulation HNRNPF TLR7 22916243 2657675 Expression of Plexin-B2 and Plexin-D1 is modulated upon *activation* of [DCs] by ligands , TNFa , and anti-CD40 , again in a reciprocal fashion . Positive_regulation HNRNPF TLR7 22962607 2667990 We could show that *induced* [DCs] are characterized by a predominance of costimulatory over coinhibitory molecules and by high secretion of IL-12p70 , but not IL-10 . Positive_regulation HNRNPF TLR7 22962607 2668030 By means of IL-12p70 secretion , only *induced* [DCs] activated NK cells . Positive_regulation HNRNPF TLR7 23257360 2724768 Given the expansion of CD11c+ DCs during the progression of atherosclerosis and the key role of T cell activation in atherogenesis , we sought to understand the *role* of signaling in CD11c+ [DCs] in atherosclerosis . Positive_regulation HNRNPF TLR7 23291967 2769324 IRF5 deficiency reduces IFN-a , IFN-ß and IL-6 production by Toll-like receptor 9 (TLR9)- and *stimulated* [DCs] and reduces TLR7- and TLR9 induced IL-6 production by B cells to a similar extent in the two lines . Positive_regulation HNRNPF TLR7 23791643 2807837 The intracellular signaling molecule TRAF6 is critical for *mediated* activation of [dendritic cells (DCs)] . Positive_regulation HNRNPF TNF 10201904 605658 Dual *stimulations* of monocyte derived [DCs] with and IL-10 selectively antagonized their respective effects on these DC properties . Positive_regulation HNRNPF TNF 11035052 740875 Contrasting with our previous report using cultured splenic DCs , freshly isolated splenic [DCs] killed YAC-1 cells using a Ca ( 2+ ) -independent mechanism , but this function did not appear *mediated* by Fas ligand , TNF related apoptosis inducing ligand , or . Positive_regulation HNRNPF TNF 11369638 817513 Here it is reported that prostaglandin E ( 2 ) ( PGE ( 2 ) ) , an inflammatory mediator with a previously known Th2 driving function , dose-dependently enhances the IL-12p40 mRNA expression and the secretion of IL-12p40 protein in human *stimulated* immature [dendritic cells (DCs)] . Positive_regulation HNRNPF TNF 11369638 817517 In addition to the selective induction of IL-12p40 in *stimulated* [DCs] , PGE ( 2 ) inhibited the production of IL-12p70 and IL-12p40 in DCs stimulated with LPS or CD40 ligand . Positive_regulation HNRNPF TNF 11781361 900316 In conclusion , this study describes that stimulation by *results* in incompletely matured [DCs] ( semi-mature DCs ) which induce peptide-specific IL-10 producing T cells in vivo and prevent EAE . Positive_regulation HNRNPF TNF 11849317 912767 In this assay we analysed the migratory ability of interleukin-4 (IL-4)/granulocyte macrophage-colony stimulating factor ( GM-CSF ) -derived immature DCs as well as mature [DCs] , *induced* by and modified vaccinia virus Ankara ( MVA ) . Positive_regulation HNRNPF TNF 12471118 1023040 Further characterization of MTSA differentiated DCs showed that they were immature in nature , as *stimulation* of these [DCs] with , anti-CD40 , or LPS further up-regulated the surface levels of various molecules together with an increase in their T cell stimulatory capacity . Positive_regulation HNRNPF TNF 12662282 1074299 [DCs] cultured in serum-free media from adherent or CD14+ apheresis MNCs ( n = 36 ) in the *presence* of GM-CSF + IL4 +/- were frozen and stored at -80 degrees C in 6-percent HES , 5-percent DMSO , and 4-percent HSA . Positive_regulation HNRNPF TNF 12832450 1105603 Phenotypic activation of [DCs] exposed to PrP ( 106-126 ) is partly a *result* of an autocrine response and results in an increased ability of these cells to induce lymphocyte proliferation . Positive_regulation HNRNPF TNF 12928370 1131963 , but not IL-1 , *induce* monocytes to become [DCs] despite the presence of fibroblasts . Positive_regulation HNRNPF TNF 12928370 1131970 *induced* [DCs] contain Langerin positive cells and are able to induce allogenic T cell proliferation . Positive_regulation HNRNPF TNF 14611814 1162835 Increasing enhanced the survival of culturing stem cells and *resulted* in a parallel increase in day 14 [DCs] . Positive_regulation HNRNPF TNF 14632659 1170659 SB203580 , a specific inhibitor of p38 MAPK , partially or markedly inhibited the phenotypic changes of [DCs] *induced* by or DNCB , respectively . Positive_regulation HNRNPF TNF 15193925 1259639 Individual expression of human SLAM , interferon alpha/beta receptor , , and lymphotoxin-alpha or beta from T cells was not *required* for MV-infected [DCs] to inhibit the proliferation of T cells . Positive_regulation HNRNPF TNF 15560757 1341028 *Stimulation* of day 8 [DCs] from AD patients with and IL-1beta enhanced the expression of CD83 and CD86 and restored the production of IL-16 . Positive_regulation HNRNPF TNF 15726369 1389626 Mature [Mo-DCs] ( mMo-DCs ) were *induced* from imMo-DCs with and prostaglandin E ( 2 ) . Positive_regulation HNRNPF TNF 15730393 1377476 However , *stimulated* [DCs] produce low levels of IL-12 . Positive_regulation HNRNPF TNF 15766407 1383663 [DCs] *induced* by GM-CSF+IL-4 and had DC-classical phenotypic characteristics . Positive_regulation HNRNPF TNF 16388755 1505801 [DCs] in peripheral blood mononuclear cells ( PBMCs ) from gastric cancer patients were *induced* with rhGM-CSF , rhIL-4 and . Positive_regulation HNRNPF TNF 17113033 1667780 Our data showed that transcript and protein of DDR2 were expressed constitutively in immature DCs and upregulated in *stimulated* mature [DCs] . Positive_regulation HNRNPF TNF 18056756 1943908 *stimulated* [DCs] have been shown to restore tolerance in experimental autoimmune encephalomyelitis and collagen induced arthritis ( CIA ) . Positive_regulation HNRNPF TNF 18180802 1883490 The results show that the T-HSP70 is capable of maturing human [DCs] *inducing* an increase in the expression level of the CD83 , CD86 and human leukocyte antigen-DR surface markers , as well as in the secretion of interleukin (IL)-12 , and IL-6 cytokines . Positive_regulation HNRNPF TNF 18318992 1881053 Differential expression patterns of PD-L1 and PD-L2 were found when [DCs] were *triggered* by CD40 ligand and . Positive_regulation HNRNPF TNF 18318992 1881061 PD-L1 expression was repressed and PD-L2 expression remained unchanged in mature CD40 ligated DCs , whereas *stimulated* [DCs] kept high expression of PD-L1 and significantly enhanced PD-L2 expression on DCs . Positive_regulation HNRNPF TNF 19058839 2023987 Using real-time RT-PCR and HPLC , the expression and activity of IDO were assessed in *induced* mature [DCs] from HDM-sensitive and nonatopic patients with asthma in response to Der p 1 exposure ex vivo . Positive_regulation HNRNPF TNF 19710690 2186340 In accordance with the elevated MMP-9 release , on co-culture with TNFalpha/IL-1beta stimulated fibroblasts , DCs migrated significantly more effectively through matrigel matrices than did *stimulated* [DCs] . Positive_regulation HNRNPF TNF 20237317 2265980 Sustained secretion is *essential* for robust T-cell activation by [DCs] . Positive_regulation HNRNPF TNF 20386470 2245243 LPS stimulation of [DCs] *induced* IL-10 , IL-12p70 , and IL-1beta secretion , and taxol pretreatment modified this response by down regulating IL-1beta secretion whereas colchicine induced a proinflammatory cytokine profile with reduced IL-10 and increased IL-12p70 and TNFalpha secretion . Positive_regulation HNRNPF TNF 20943074 2332968 [DCs] from healthy human peripheral monocytes ( PBMCs ) were *induced* in vitro with rhGM-CSF , rhIL-4 , Flt3-L and . Positive_regulation HNRNPF TNF 22257833 2564428 We also noted elevated levels of inflammatory mediators , of which *activates* [DCs] and endothelial cells-was the highest . Positive_regulation HNRNPF TNF 22486596 2606871 Here , we show that parasite GPIs efficiently activate [DCs] through TLR2 mediated signalling mechanism and *induce* the production of and IL-12 . Positive_regulation HNRNPF TNF 7561684 324228 These [CFU-DCs] can be expanded for several weeks by in vitro culture with c-kit-ligand , and their differentiation *requires* exogenous in addition to GM-CSF . Positive_regulation HNRNPF TNF 8542932 338750 We show that the *dependent* ex vivo generation of [DCs] from mobilized CD34+ cells is 2.5-fold enhanced by flk-2/flt-3 ligand or c-kit ligand ( stem cell factor ) and five-fold enhanced by a combination of these growth factors . Positive_regulation HNRNPF TNFSF10 11035052 740876 Contrasting with our previous report using cultured splenic DCs , freshly isolated splenic [DCs] killed YAC-1 cells using a Ca ( 2+ ) -independent mechanism , but this function did not appear *mediated* by Fas ligand , , or TNF-alpha . Positive_regulation HNRNPH1 CCL17 12909129 1121890 Endogenous CCL17 and B7-DC mRNAs were increased similarly in IL-4 cultured [DCs] but only was *induced* by LPS . Positive_regulation HNRNPH1 CD14 9680340 521001 Cultures enriched in *dependent* [DCs] were more potent stimulators of a mixed leukocyte reaction , compared with control GTS cultures containing both types of DCs . Positive_regulation HNRNPH1 CD14 9680340 521009 When exposed to the appropriate cytokine combinations , these cells yielded granulocytes , monocytes , and *dependent* [DCs] . Positive_regulation HNRNPH1 CD14 9680340 521013 Although TNF is required to ensure the institution of DC hematopoiesis from CD34 ( + ) progenitor cells , its activity on a later progenitor appears to limit the development of *dependent* [DCs] . Positive_regulation HNRNPH1 EDN2 15528350 1332541 Additionally , and hPR also *induced* phenotypic and functional maturation [DCs] . Positive_regulation HNRNPH1 EDN2 18195069 1857030 Here , we report that can *activate* myeloid [DCs] by triggering the Toll-like receptor (TLR)2-myeloid differentiation factor 88 signaling pathway , thus establishing EDN as an endogenous ligand of TLR2 . Positive_regulation HNRNPH1 EPHB2 20967853 2369598 Selective activation *induced* mouse and human [DCs] to secrete bioactive transforming growth factor ß , a process required for suppression of T cell responses and differentiation of antigen-specific Treg cells . Positive_regulation HNRNPH1 FAS 10756053 682847 In this study , human monocyte derived [DCs] were used to demonstrate that DC apoptosis in MV-infected DC-T-cell cocultures is *mediated* , whereas apoptotic T cells could not be rescued by blocking the Fas pathway . Positive_regulation HNRNPH1 FAS 10756053 682857 A model is proposed to explain how both a specific immune response and immunosuppression can simultaneously occur after MV infection through *mediated* apoptosis and CD40 activation of [DCs] . Positive_regulation HNRNPH1 FAS 11104808 756543 *activated* [DCs] upregulate the expression of the major histocompatibility complex class II , B7 , and DC-lysosome associated membrane protein ( DC-LAMP ) molecules and secrete proinflammatory cytokines , in particular interleukin (IL)-1beta and tumor necrosis factor alpha . Positive_regulation HNRNPH1 FAS 23943615 2845260 Here , we show that CD11b ( hi ) Ia ( low ) regulatory [DCs] expressed high level of Fas , and endothelial stromal cell derived TGF-ß could *induce* high expression of on regulatory DCs via ERK activation . Positive_regulation HNRNPH1 FAS 23943615 2845269 ligation could *promote* regulatory [DCs] to inhibit CD4 ( + ) T cell proliferation more significantly . Positive_regulation HNRNPH1 FAS 23943615 2845277 Furthermore , ligation preferentially *induced* regulatory [DCs] to produce IL-10 and IP-10 via ERK mediated inactivation of GSK-3 and subsequent up-regulation of ß-catenin . Positive_regulation HNRNPH1 IL1B 14666382 1242533 Monocyte derived [DCs] were generated in a culture of monocyte with interleukin 4 (IL-4) and granulocyte-macrophage colony stimulating factor , and the maturation of DCs was *induced* by either lipopolysaccharide (LPS) or a proinflammatory cytokine cocktail : tumor-necrosis factor alpha , prostaglandin E2 , IL-6 , and . Positive_regulation HNRNPH1 IL1B 15560757 1341031 *Stimulation* of day 8 [DCs] from AD patients with TNF-alpha and enhanced the expression of CD83 and CD86 and restored the production of IL-16 . Positive_regulation HNRNPH1 IL1B 20386470 2245254 LPS stimulation of [DCs] *induced* IL-10 , IL-12p70 , TNFalpha and secretion , and taxol pretreatment modified this response by down regulating IL-1beta secretion whereas colchicine induced a proinflammatory cytokine profile with reduced IL-10 and increased IL-12p70 and TNFalpha secretion . Positive_regulation HNRNPH1 ITGB2 19234188 2040159 Taken together , one of the mechanisms of Treg mediated suppression functions across species and mediates an *dependent* interaction between Tregs and [DCs] . Positive_regulation HNRNPH1 ITGB2 23817428 2815792 Therefore , our results indicate that *dependent* interactions between T cells and [DCs] play a crucial role not only in supporting firm arrest during Ag recognition but also in facilitating the Ag scanning processes . Positive_regulation HNRNPH1 JAG1 19003206 1184960 Our results show that orally administered *induce* systemic T cell unresponsiveness through splenic [DCs] without inducing cell division of T cells , thus providing evidence that splenic DCs are involved in oral tolerance induction . Positive_regulation HNRNPH1 MAP2K6 24670797 2934975 Our previous research demonstrates that *activation* of [dendritic cells (DCs)] through is required for Ni-induced allergy in mice . Positive_regulation HNRNPH1 S1PR3 20826749 2325216 Thus , in vitro generated [DCs] *require* S1P(1) and to accomplish this , whereas skin derived DCs migrate unhindered in the absence of S1P(3) but not when S1P(1) signaling is blocked . Positive_regulation HNRNPH1 TCN1 24296809 2921398 Functionally , OK-432 plus IFN-? conditioned [DCs] *induce* remarkable Th1 and responses more effectively than OK-432 alone , even more than the use of a-type-1 cytokine cocktail . Positive_regulation HNRNPH1 TLR7 12515817 1039221 Polarized Th1 responses resulting from high antigen dose were not additionally enhanced by *stimulation* of [DCs] by ligands . Positive_regulation HNRNPH1 TLR7 12682240 1077637 We hypothesized that microbial ligands could *activate* [DCs] to cross-present Ag to CTLs . Positive_regulation HNRNPH1 TLR7 12776992 1095459 Each can *activate* [DCs] in a similar , but distinct manner . Positive_regulation HNRNPH1 TLR7 15585847 1345799 Thus , proinflammatory cytokines produced by *activated* , mature [DCs] are required for reversal of Treg anergy , but are not required to overcome Treg suppression . Positive_regulation HNRNPH1 TLR7 15597784 1346531 We demonstrate that SOCS1 and SOCS3 *play* an important regulatory role in macrophages and [dendritic cells (DCs)] by modulating signaling . Positive_regulation HNRNPH1 TLR7 15995707 1434808 Synergic stimulation increased production of interleukins 12 and 23 and *increased* the Delta-4/Jagged-1 ratio , leading to [DCs] with enhanced and sustained T helper type 1-polarizing capacity . Positive_regulation HNRNPH1 TLR7 16219795 1508108 Interleukin-12 (IL-12) is a heterodimeric cytokine produced by [dendritic cells (DCs)] in *response* to ligation . Positive_regulation HNRNPH1 TLR7 17041145 1649349 In conclusion , we demonstrate that the anti-microbial peptide LL-37 inhibits the *activation* of [DCs] by ligands . Positive_regulation HNRNPH1 TLR7 17218388 1724868 In our study we demonstrate that *stimulation* of monocyte derived [DCs] with ligands differentially affects the uptake and cross-presentation of cellular antigens . Positive_regulation HNRNPH1 TLR7 17237413 1689912 In this study we demonstrate that the ability of *activated* [DCs] to suppress Th2 cell development is Ag dose independent and unique to DCs that have been activated through TLRs vs by cytokines . Positive_regulation HNRNPH1 TLR7 17237413 1689956 We show that *activated* [DCs] inhibit early IL-4 production by CD4 T cells and thus inhibit their ability to subsequently increase GATA-3 expression and commit to the Th2 lineage . Positive_regulation HNRNPH1 TLR7 17238832 1664270 Further , Stat3 was phosphorylated and bound to the IL-10 promoter in *stimulated* [DCs] . Positive_regulation HNRNPH1 TLR7 17414322 1722526 Together , our data suggest that ligands *induce* the generation of mature [DCs] that integrate migratory and cytokine secretory capacity as well as cytotoxic T lymphocyte ( CTL ) stimulatory properties . Positive_regulation HNRNPH1 TLR7 17430585 1728929 ligand stimulation *induced* [DCs] capable of secreting IL-12p70 in primary cultures and after one day of coculture with CD40L expressing fibroblasts , mimicking an encounter with T cells . Positive_regulation HNRNPH1 TLR7 17508961 1745097 Activation of TLRs by administration of specific bacterial ligands , in particular lipopolysaccharide , can augment airway sensitization in mice , and there is evidence that this process involves *dependent* activation of [DCs] . Positive_regulation HNRNPH1 TLR7 17548596 1752159 Produced by [dendritic cells (DCs)] in *response* to ligands , IL-27 recently emerged as a key regulator of inflammatory responses . Positive_regulation HNRNPH1 TLR7 17848994 1795796 mediated *activation* of [dendritic cells (DCs)] is known to be a critical event in the initiation of cellular and humoral immune responses . Positive_regulation HNRNPH1 TLR7 18259609 1877400 A prerequisite for strong adaptive antiviral immunity is the robust initial activation of the innate immune system , which is frequently mediated by *activated* plasmacytoid [DCs] ( pDCs ) . Positive_regulation HNRNPH1 TLR7 18424745 1899974 Furthermore , T. gondii activated plasmacytoid [DCs] produce high levels of IL-12 and both plasmacytoid DC maturation and cytokine production are *dependent* on . Positive_regulation HNRNPH1 TLR7 19017945 1991921 In these ways , *activated* [DCs] are able to activate naive Th cells and initiate Th1 and Th17 responses , and TLR ligands thus serve as adjuvants for these types of responses . Positive_regulation HNRNPH1 TLR7 19164127 2048390 We also showed that the Jak/STAT signaling pathway was involved in CD40 expression and cytokine production in *stimulated* [DCs] but negatively regulated CD83 expression and cytokine secretion in DCs activated through TLR8 . Positive_regulation HNRNPH1 TLR7 19255934 2175730 The aim of our study was to determine whether *mediated* stimulation of monocytes and [dendritic cells (DCs)] contributes to the higher levels of CCL18 in SSc . Positive_regulation HNRNPH1 TLR7 19625644 2118373 We have investigated the ability of *stimulated* human Langerhans cells ( LC ) , dermal DCs (dDC) , and monocyte derived [DCs] ( moDC ) to affect naive and memory Th17 and Th1 responses . Positive_regulation HNRNPH1 TLR7 19625644 2118413 *stimulated* [DCs] were capable of inducing IL-17A and IFN-gamma production from memory T cells , although the mechanism used by each DC subset differed . Positive_regulation HNRNPH1 TLR7 19836139 2196407 Additionally , saliva treated [DCs] also presented a similar pattern of cytokine modulation in *response* to other ligands . Positive_regulation HNRNPH1 TLR7 19854106 2203263 Here , we demonstrate that several ligands , particularly LPS and a synthetic lipoprotein , *activate* human [DCs] to direct increased human Th17 differentiation . Positive_regulation HNRNPH1 TLR7 20200270 2229547 In *response* to signaling , conventional [DCs] can also produce IFN-beta but not IFN-alpha in a type I IFN independent manner . Positive_regulation HNRNPH1 TLR7 20361966 2282017 TcES with chemically altered glycans failed to modulate mediated *activation* of [DCs] and their Th1-inhibitng ability , which was STAT6 independent . Positive_regulation HNRNPH1 TLR7 20451253 2275263 However , down-modulation of chemokine production was observed in simultaneously *stimulated* [DCs] . Positive_regulation HNRNPH1 TLR7 20498209 2289101 Systemic sclerosis ( SSc ) is an autoimmune disease and accumulating evidence suggests a role for *mediated* activation of [dendritic cells (DCs)] . Positive_regulation HNRNPH1 TLR7 20498209 2289161 The altered mediated *activation* of [DCs] may be responsible for Th2 skewed T-cell activation in SSc that may be orchestrated by fibrogenic T-cell cytokines , such as IL-4 and IL-13 . Positive_regulation HNRNPH1 TLR7 20547386 2295873 Collectively , these results demonstrate that dsRNA activated DCs induce more highly polarized human Th1 responses than the other ligand *activated* [DCs] tested here . Positive_regulation HNRNPH1 TLR7 21469103 2422737 In the presence of *activated* splenic [DCs] , Foxp3 was transiently induced in naïve T cells by TGF-ß but was downregulated at later time points . Positive_regulation HNRNPH1 TLR7 21493800 2444175 These results suggest that TLR4 and signals together *induce* [DCs] with fully mature and less mature phenotypes that are both required to more efficiently prime CD8+ T cells with qualities associated with memory T cells . Positive_regulation HNRNPH1 TLR7 21690322 2455620 DCs are important primary targets of TSLP , and we unexpectedly demonstrated that [DCs] also produce TSLP in *response* to stimulation and that this is augmented by IL-4 . Positive_regulation HNRNPH1 TLR7 21711348 2460690 In this study , we attempted to determine whether AIMP1 is capable of regulating the expression of TLRs , and also capable of affecting the mediated *activation* of [DCs] . Positive_regulation HNRNPH1 TLR7 22482518 2589165 Our data show that soluble products of T. suis , S. mansoni and T. spiralis suppress TNF-a and IL-12 secretion by *activated* human [DCs] , and that T. suis and S. mansoni , but not T. spiralis , strongly enhance expression of OX40L . Positive_regulation HNRNPH1 TLR7 22534476 2618638 *activated* conventional [DCs] promote ?-secretase mediated conditioning of plasmacytoid DCs . Positive_regulation HNRNPH1 TLR7 22753939 2627328 We demonstrate that concurrent Notch and stimulation results in a unique cytokine profile in mouse bone-marrow *derived* [DCs] characterized by enhanced IL-10 and IL-2 , and reduced IL-12 expression compared with TLR ligation alone . Positive_regulation HNRNPH1 TLR7 22777000 2719478 Synergistic *activated* [DCs] were also able to induce lymphocytes possessing the specific cytotoxicity against MC38-CEA cells in vitro . Positive_regulation HNRNPH1 TLR7 22916243 2657686 Expression of Plexin-B2 and Plexin-D1 is modulated upon *activation* of [DCs] by ligands , TNFa , and anti-CD40 , again in a reciprocal fashion . Positive_regulation HNRNPH1 TLR7 22962607 2668000 We could show that *induced* [DCs] are characterized by a predominance of costimulatory over coinhibitory molecules and by high secretion of IL-12p70 , but not IL-10 . Positive_regulation HNRNPH1 TLR7 22962607 2668040 By means of IL-12p70 secretion , only *induced* [DCs] activated NK cells . Positive_regulation HNRNPH1 TLR7 23257360 2724778 Given the expansion of CD11c+ DCs during the progression of atherosclerosis and the key role of T cell activation in atherogenesis , we sought to understand the *role* of signaling in CD11c+ [DCs] in atherosclerosis . Positive_regulation HNRNPH1 TLR7 23291967 2769325 IRF5 deficiency reduces IFN-a , IFN-ß and IL-6 production by Toll-like receptor 9 (TLR9)- and *stimulated* [DCs] and reduces TLR7- and TLR9 induced IL-6 production by B cells to a similar extent in the two lines . Positive_regulation HNRNPH1 TLR7 23791643 2807847 The intracellular signaling molecule TRAF6 is critical for *mediated* activation of [dendritic cells (DCs)] . Positive_regulation HNRNPH1 TNF 10201904 605660 Dual *stimulations* of monocyte derived [DCs] with and IL-10 selectively antagonized their respective effects on these DC properties . Positive_regulation HNRNPH1 TNF 11035052 740878 Contrasting with our previous report using cultured splenic DCs , freshly isolated splenic [DCs] killed YAC-1 cells using a Ca ( 2+ ) -independent mechanism , but this function did not appear *mediated* by Fas ligand , TNF related apoptosis inducing ligand , or . Positive_regulation HNRNPH1 TNF 11369638 817514 Here it is reported that prostaglandin E ( 2 ) ( PGE ( 2 ) ) , an inflammatory mediator with a previously known Th2 driving function , dose-dependently enhances the IL-12p40 mRNA expression and the secretion of IL-12p40 protein in human *stimulated* immature [dendritic cells (DCs)] . Positive_regulation HNRNPH1 TNF 11369638 817518 In addition to the selective induction of IL-12p40 in *stimulated* [DCs] , PGE ( 2 ) inhibited the production of IL-12p70 and IL-12p40 in DCs stimulated with LPS or CD40 ligand . Positive_regulation HNRNPH1 TNF 11781361 900317 In conclusion , this study describes that stimulation by *results* in incompletely matured [DCs] ( semi-mature DCs ) which induce peptide-specific IL-10 producing T cells in vivo and prevent EAE . Positive_regulation HNRNPH1 TNF 11849317 912768 In this assay we analysed the migratory ability of interleukin-4 (IL-4)/granulocyte macrophage-colony stimulating factor ( GM-CSF ) -derived immature DCs as well as mature [DCs] , *induced* by and modified vaccinia virus Ankara ( MVA ) . Positive_regulation HNRNPH1 TNF 12471118 1023042 Further characterization of MTSA differentiated DCs showed that they were immature in nature , as *stimulation* of these [DCs] with , anti-CD40 , or LPS further up-regulated the surface levels of various molecules together with an increase in their T cell stimulatory capacity . Positive_regulation HNRNPH1 TNF 12662282 1074302 [DCs] cultured in serum-free media from adherent or CD14+ apheresis MNCs ( n = 36 ) in the *presence* of GM-CSF + IL4 +/- were frozen and stored at -80 degrees C in 6-percent HES , 5-percent DMSO , and 4-percent HSA . Positive_regulation HNRNPH1 TNF 12832450 1105604 Phenotypic activation of [DCs] exposed to PrP ( 106-126 ) is partly a *result* of an autocrine response and results in an increased ability of these cells to induce lymphocyte proliferation . Positive_regulation HNRNPH1 TNF 12928370 1131965 , but not IL-1 , *induce* monocytes to become [DCs] despite the presence of fibroblasts . Positive_regulation HNRNPH1 TNF 12928370 1131971 *induced* [DCs] contain Langerin positive cells and are able to induce allogenic T cell proliferation . Positive_regulation HNRNPH1 TNF 14611814 1162836 Increasing enhanced the survival of culturing stem cells and *resulted* in a parallel increase in day 14 [DCs] . Positive_regulation HNRNPH1 TNF 14632659 1170660 SB203580 , a specific inhibitor of p38 MAPK , partially or markedly inhibited the phenotypic changes of [DCs] *induced* by or DNCB , respectively . Positive_regulation HNRNPH1 TNF 15193925 1259642 Individual expression of human SLAM , interferon alpha/beta receptor , , and lymphotoxin-alpha or beta from T cells was not *required* for MV-infected [DCs] to inhibit the proliferation of T cells . Positive_regulation HNRNPH1 TNF 15560757 1341030 *Stimulation* of day 8 [DCs] from AD patients with and IL-1beta enhanced the expression of CD83 and CD86 and restored the production of IL-16 . Positive_regulation HNRNPH1 TNF 15726369 1389627 Mature [Mo-DCs] ( mMo-DCs ) were *induced* from imMo-DCs with and prostaglandin E ( 2 ) . Positive_regulation HNRNPH1 TNF 15730393 1377477 However , *stimulated* [DCs] produce low levels of IL-12 . Positive_regulation HNRNPH1 TNF 15766407 1383666 [DCs] *induced* by GM-CSF+IL-4 and had DC-classical phenotypic characteristics . Positive_regulation HNRNPH1 TNF 16388755 1505803 [DCs] in peripheral blood mononuclear cells ( PBMCs ) from gastric cancer patients were *induced* with rhGM-CSF , rhIL-4 and . Positive_regulation HNRNPH1 TNF 17113033 1667781 Our data showed that transcript and protein of DDR2 were expressed constitutively in immature DCs and upregulated in *stimulated* mature [DCs] . Positive_regulation HNRNPH1 TNF 18056756 1943909 *stimulated* [DCs] have been shown to restore tolerance in experimental autoimmune encephalomyelitis and collagen induced arthritis ( CIA ) . Positive_regulation HNRNPH1 TNF 18180802 1883493 The results show that the T-HSP70 is capable of maturing human [DCs] *inducing* an increase in the expression level of the CD83 , CD86 and human leukocyte antigen-DR surface markers , as well as in the secretion of interleukin (IL)-12 , and IL-6 cytokines . Positive_regulation HNRNPH1 TNF 18318992 1881055 Differential expression patterns of PD-L1 and PD-L2 were found when [DCs] were *triggered* by CD40 ligand and . Positive_regulation HNRNPH1 TNF 18318992 1881062 PD-L1 expression was repressed and PD-L2 expression remained unchanged in mature CD40 ligated DCs , whereas *stimulated* [DCs] kept high expression of PD-L1 and significantly enhanced PD-L2 expression on DCs . Positive_regulation HNRNPH1 TNF 19058839 2023988 Using real-time RT-PCR and HPLC , the expression and activity of IDO were assessed in *induced* mature [DCs] from HDM-sensitive and nonatopic patients with asthma in response to Der p 1 exposure ex vivo . Positive_regulation HNRNPH1 TNF 19710690 2186342 In accordance with the elevated MMP-9 release , on co-culture with TNFalpha/IL-1beta stimulated fibroblasts , DCs migrated significantly more effectively through matrigel matrices than did *stimulated* [DCs] . Positive_regulation HNRNPH1 TNF 20237317 2265981 Sustained secretion is *essential* for robust T-cell activation by [DCs] . Positive_regulation HNRNPH1 TNF 20386470 2245249 LPS stimulation of [DCs] *induced* IL-10 , IL-12p70 , and IL-1beta secretion , and taxol pretreatment modified this response by down regulating IL-1beta secretion whereas colchicine induced a proinflammatory cytokine profile with reduced IL-10 and increased IL-12p70 and TNFalpha secretion . Positive_regulation HNRNPH1 TNF 20943074 2332971 [DCs] from healthy human peripheral monocytes ( PBMCs ) were *induced* in vitro with rhGM-CSF , rhIL-4 , Flt3-L and . Positive_regulation HNRNPH1 TNF 22257833 2564429 We also noted elevated levels of inflammatory mediators , of which *activates* [DCs] and endothelial cells-was the highest . Positive_regulation HNRNPH1 TNF 22486596 2606874 Here , we show that parasite GPIs efficiently activate [DCs] through TLR2 mediated signalling mechanism and *induce* the production of and IL-12 . Positive_regulation HNRNPH1 TNF 7561684 324229 These [CFU-DCs] can be expanded for several weeks by in vitro culture with c-kit-ligand , and their differentiation *requires* exogenous in addition to GM-CSF . Positive_regulation HNRNPH1 TNF 8542932 338755 We show that the *dependent* ex vivo generation of [DCs] from mobilized CD34+ cells is 2.5-fold enhanced by flk-2/flt-3 ligand or c-kit ligand ( stem cell factor ) and five-fold enhanced by a combination of these growth factors . Positive_regulation HNRNPH1 TNFSF10 11035052 740879 Contrasting with our previous report using cultured splenic DCs , freshly isolated splenic [DCs] killed YAC-1 cells using a Ca ( 2+ ) -independent mechanism , but this function did not appear *mediated* by Fas ligand , , or TNF-alpha . Positive_regulation HNRNPK EPHB2 11231586 789586 Our results establish the *role* of in phosphorylation dependent cellular localization of [hnRNP-K] , which is required for its ability to silence mRNA translation . Positive_regulation HNRNPK EPHB2 19880579 2165786 Our data showed a clear *dependent* increase in one form of [hnRNP-K] after TCR stimulation . Positive_regulation HNRNPU MMP7 18653469 1967106 H. pylori increases mRNA levels in a cag- and p120 dependent manner and *induces* translocation of [p120] to the nucleus in vitro and in a novel ex vivo gastric gland culture system . Positive_regulation HNRNPU TLR7 22345668 2572070 Therefore , we propose that [hnRNP U] *induced* by signaling binds to the mRNA of a subset of proinflammatory cytokines and positively regulates the expression of these cytokines by stabilizing mRNA . Positive_regulation HOMER1 EPHB2 24167026 2889711 These data indicate that [Homer1c-mGluR5] interactions are necessary for mGluR dependent LTP , and that mGluR1/5 dependent LTP *involves* PI3K and activation . Positive_regulation HOXA@ NES 23487024 2794205 The CALM is *essential* for CALM-AF10 dependent [Hoxa] gene up-regulation and aberrant H3K79 methylation , possibly by mislocalization of DOT1L . Positive_regulation HOXA1 NR2F1 23018522 2720233 Moreover , analysis of the expression of primary RA response genes indicates that is *involved* in the regulatory modulation of the expression of at least two genes , CYP26A1 and [HoxA1] . Positive_regulation HOXA1 RARB 20231276 2254510 [Hoxa1] and Cyp26a1 transcripts are not expressed , but ( 2 ) transcripts are *induced* by RA in mouse embryonic fibroblasts and Balb/c3T3 cells . Positive_regulation HOXA10 IL1B 16551735 1568215 Thrombin and *regulate* [HOXA10] expression in human term decidual cells : implications for preterm labor . Positive_regulation HOXB13 FOXA1 20018680 2191697 These data demonstrate that directly *regulates* [HOXB13] in human prostate epithelial cells , and show that this prostate-specific regulatory mechanism is conserved in mice . Positive_regulation HOXB2 EGR2 11336508 812020 Differences in *dependent* regulation of Hoxa2 and [Hoxb2] during hindbrain development . Positive_regulation HOXB2 EGR2 8093858 210084 The zinc finger gene *regulates* [HoxB2] ( Hox2.8 ) during hindbrain segmentation . Positive_regulation HOXB2 GATA1 7876223 298549 Transcription factor *regulates* human [HOXB2] gene expression in erythroid cells . Positive_regulation HOXB2 PREP 17875935 1818351 p160 and Pbx1 compete for Prep1 in vitro , and p160 inhibits *dependent* [HoxB2] expression in retinoic acid treated NT2-D1 cells . Positive_regulation HOXC13 FOXQ1 16835220 1613006 We provide evidence that is a downstream *target* for [Hoxc13] based on DNA binding studies as well as co-transfection and chromatin immunoprecipitation assays . Positive_regulation HOXD@ RARB 8792611 380995 There was no evidence to suggest that 2/beta 4 promoter activity *mediates* the effects of RA on [HoxD] gene expression , but ectopic promoter activity is a useful indicator of at least some of the sites in which RA levels are raised . Positive_regulation HP IL1B 16943422 1609520 Ectopic expression of LRH-1 with adenovirus resulted in strong inhibition of both interleukin-6 (IL-6)- and *stimulated* [haptoglobin] , serum amyloid A , and fibrinogen beta gene expression in hepatocytes . Positive_regulation HP IL1B 18240213 1871414 and TNFalpha *caused* increased release of chitinase 3-like protein 1 (CHI3L1) , CHI3L2 , complement factor B , matrix metalloproteinase 3 , ECM-1 , [haptoglobin] , serum amyloid A3 , and clusterin . Positive_regulation HP IL1B 20155810 2227739 Upregulation of [haptoglobin (Hp)] expression in the rat during the acute phase ( AP ) response is the *result* of synergistic effects of IL-6- , , and corticosterone activated signaling pathways . Positive_regulation HP TF 8614026 353582 The relative concentrations of [haptoglobin] , beta-lipoprotein , alpha-1-antitrypsin , an unknown peak `` X , `` and *increased* exponentially following a mild initial drop , while albumin , C3c + C3 , alpha-1-acid glycoprotein , alpha-1-lipoprotein , and macroglobulin declined continually during the experiment . Positive_regulation HP TNF 10229868 611192 *induced* [haptoglobin] release from human neutrophils : pivotal role of the TNF p55 receptor . Positive_regulation HP TNF 18240213 1871413 IL-1beta and *caused* increased release of chitinase 3-like protein 1 (CHI3L1) , CHI3L2 , complement factor B , matrix metalloproteinase 3 , ECM-1 , [haptoglobin] , serum amyloid A3 , and clusterin . Positive_regulation HP TNF 2460085 98226 Human recombinant tumour necrosis factor ( ) induced a dose dependent *increase* in synthesis of [haptoglobin] and ceruloplasmin . Positive_regulation HPDL TNF 11063386 746759 Furthermore , RXM suppressed activation of transcription factors AP-1 and SP-1 , which were critical factors in VEGF transcription , in *stimulated* [HPDL] cells . Positive_regulation HPSE NT5E 10545017 564207 In this study , we demonstrated that nerve growth factor (NGF) , the prototypic NT , and increased in vitro invasion through a reconstituted basement membrane and *induced* time- and dose dependent expression of [heparanase] , a heparan sulfate-specific endo-beta-D-glucuronidase , an important molecular determinant of tumor metastasis . Positive_regulation HPSE TNF 15109255 1240854 Inhibitors to nuclear factor-kappaB (NFkappaB) , PI3-kinase , MAP kinase , or c-jun kinase ( JNK ) did not affect *induced* [heparanase] secretion . Positive_regulation HPSE TNF 15109255 1240855 Interestingly , inhibition of caspase-8 completely abolished [heparanase] secretion *induced* by . Positive_regulation HPT TCN1 21512823 2458437 of ketamine with a Ce of 30 and 60 ng/ml *increased* TST but not [HPT] . Positive_regulation HRAS AGR2 7511643 250151 This event is accompanied by the tyrosine phosphorylation of the p21ras associated GTPase activating protein p120 ras . GAP , raising the possibility that *stimulated* [p21ras] activity is regulated by protein tyrosine kinases ( PTKs ) and protein tyrosine phosphatases ( PTPases ) in B cells . Positive_regulation HRAS AGR2 7511643 250153 To test this possibility , we examined the effects of PTK and PTPase inhibitors on protein tyrosine phosphorylation and [p21ras] activation *induced* by cross linking in TNP-specific TA3 7.9 murine B lymphoma cells . Positive_regulation HRAS AGR2 7511643 250158 Genistein and herbimycin A and PAO each blocked *stimulated* [p21ras] activation . Positive_regulation HRAS AGR2 7511643 250163 These data indicate that [p21ras] activation *induced* by cross linking in B cells is regulated by both PTK and CD45 PTPase activities . Positive_regulation HRAS AGR2 8021500 263065 Ligation of the B cell *activates* [p21ras] ( Ras ) . Positive_regulation HRAS AGR2 8021500 263073 These events may be important for *activation* of [Ras] by the . Positive_regulation HRAS ANGPT1 12039842 954274 Accordingly , ephrinB2 inhibited VEGF- and *induced* [Ras-MAPK] activities , whereas ephrinB2 did not alter VEGF induced Flk phosphorylation or Ang1 induced Tie2 phosphorylation . Positive_regulation HRAS CCND1 10969813 728444 Mutational and nonmutational *activation* of [p21ras] in rat colonic azoxymethane induced tumors : effects on mitogen activated protein kinase , cyclooxygenase-2 , and . Positive_regulation HRAS CCND1 11223027 787810 Thus , [Ras] activity during G2 phase *induces* expression . Positive_regulation HRAS CCND1 12429909 1015095 These studies were designed to understand how [Ras] could *induce* levels only during G2 phase . Positive_regulation HRAS CCND1 7559524 323617 The *activation* of transcription by [p21ras] provides evidence for cross-talk between the p21ras and cell cycle regulatory pathways . Positive_regulation HRAS CCND1 7791772 313381 These results suggest that increased expression of is *necessary* but not sufficient for the transforming activity of [v-H-Ras] . Positive_regulation HRAS CTGF 15855807 1425608 TGF-beta1 induced connective tissue growth factor ( ) expression in human renal proximal tubule epithelial cells *requires* [Ras/MEK/ERK] and Smad signalling . Positive_regulation HRAS EDN2 17707940 1800757 Endothelin stimulated protein kinase C ( PKC ) was partially inhibited by both YM-254890 and pertussis toxin , while only pertussis toxin attenuated induced [Ras] *activation* . Positive_regulation HRAS EPHB2 10898494 712065 Here , we analyzed the effects of Vav on three known downstream targets of [Ras] , i. e. *activation* of and NFAT , and up-regulation of the activation antigen CD69 . Positive_regulation HRAS EPHB2 10978313 751956 Whereas the essential *roles* of and JNK in [Ras] signaling has been established , the contribution of p38 remains unclear . Positive_regulation HRAS EPHB2 11018025 752780 Expression of a dominant negative mutant of Ras also did not significantly impair calcium induced ERK activation , indicating that calcium mediated activation does not *require* active [Ras] . Positive_regulation HRAS EPHB2 11088001 764963 We show that the activation of via SSTR1 is mediated by the betagamma subunit of a pertussis toxin-sensitive G-protein and *requires* both the small G protein [Ras] and the serine/threonine kinase Raf-1 . Positive_regulation HRAS EPHB2 11533045 868828 Expression of constitutively activated [Ha-Ras] , which *induces* strong activation of , led to the proliferation inhibition of HepG2 cells , as was observed in HGF treated HepG2 cells . Positive_regulation HRAS EPHB2 11574537 882426 NT-stimulated activity *requires* [Ras] activation because overexpression of the dominant negative Ras mutant Ras-17N almost completely inhibits the Erk activation . Positive_regulation HRAS EPHB2 12364324 1019149 GLP1 stimulated activation of is blocked by inhibitors of MEK , but GLP1 does not *induce* the activation of A-Raf , B-Raf , C-Raf , or [Ras] . Positive_regulation HRAS EPHB2 12902401 1121120 LPA induced chemotaxis is markedly dependent on activation of PTX-sensitive heterotrimeric G-proteins , on activation of the small GTPases [Ras] , Rac and RhoA , and on GTPase dependent *activation* of . Positive_regulation HRAS EPHB2 15205467 1281172 Thus , unlike galectin-1 , which prolongs [Ras] *activation* of and inhibits PI3-K , K-Ras-GTP/galectin-3 interactions promote , in addition to PI3-K and Raf-1 activation , a third inhibitory signal that attenuates active ERK . Positive_regulation HRAS EPHB2 15650750 1364058 Influx of calcium , mediated either by L-type voltage-sensitive calcium channels or glutamate receptors , is associated with the suppression of brain derived neurotrophic factor (BDNF) *activation* of [Ras] and its effectors and Akt . Positive_regulation HRAS EPHB2 16339563 1491668 In that pharmacological inhibitors of PI3K inhibited LPS induced activation of [p21Ras] , but not *activation* of , we concluded that LPS induced activation of ERK occurs through a pathway that is not dependent on the activation of p21Ras . Positive_regulation HRAS EPHB2 16436505 1540514 In addition , we demonstrated that Tat activation of [Ras] , but not of Rac , *induces* phosphorylation . Positive_regulation HRAS EPHB2 20176802 2222129 [Ras] *activation* of restores impaired tonic BCR signaling and rescues immature B cell differentiation . Positive_regulation HRAS EPHB2 20639215 2322042 We found that phosphorylation of this receptor contributed to [Ras] and ERK activation and that inhibition of , PKC , and EGFR *blocked* the mitogenic response induced by sPLA ( 2 ) -IIA . Positive_regulation HRAS EPHB2 21330403 2420300 Measurements of the dephosphorylation of and the *activation* of [Ras] showed that the ROS scavenger prevents the cAMP provoked activation of Ras and that cAMP , with or without a ROS scavenger , has little or no effect on the dephosphorylation of ERK . Positive_regulation HRAS EPHB2 21771815 2456802 [Ras] continues to promote subsequent aspects of duct morphogenesis and differentiation , and *acts* primarily through and the transcriptional effectors LIN-1/Ets and EOR-1 . Positive_regulation HRAS EPHB2 21949793 2488021 Like costimulation via CD28 , active [Ras] *induced* AKT , JNK and phosphorylation . Positive_regulation HRAS EPHB2 22258408 2544909 We observed that loss of mitochondrial genome reversibly *induced* overexpression and activation of proto-oncogenic [Ras] , especially K-Ras 4A , responsible for the activation of AKT and leading to advanced phenotype of prostate and breast cancer . Positive_regulation HRAS EPHB2 22617030 2614669 Autonomous activation by uPAR *requires* [H-Ras] and Rac1 . Positive_regulation HRAS EPHB2 22687285 2643695 *activation* of [RAS] signaling to LKB1 and RASGRP3 , via and p90RSK , might be involved in liver carcinogenesis and be used as a prognostic marker . Positive_regulation HRAS EPHB2 23153539 2699903 RAF inhibitors potently inhibit RAF monomers and ERK signaling , causing relief of *dependent* feedback , reactivation of ligand dependent signal transduction , increased [Ras-GTP] , and generation of RAF-inhibitor-resistant RAF dimers . Positive_regulation HRAS EPHB2 24309939 2877895 Molecular docking analysis suggested that WA could bind to HRas-GTP , causing accumulation of [Ras-GTP] and excessive *activation* of . Positive_regulation HRAS EPHB2 9234703 445394 [Ras] *activation* of was inhibited by both Pak1 ( R299 ) and Pak1 ( L83,L86,R299 ) , while neither mutant inhibited Raf activation of ERK . Positive_regulation HRAS EPHB2 9556628 499866 A dominant negative form of RHAMMv4 inhibits mutant active [Ras] *activation* of and coimmunoprecipitates with both mitogen activated protein kinase kinase and ERK , suggesting that the intracellular RHAMMv4 acts downstream of Ras , possibly at the level of mitogen activated protein kinase kinase-ERK interactions . Positive_regulation HRAS EPHB2 9892010 586564 We show that the activation of via SSTR1 is pertussis toxin sensitive and *requires* the small G protein [Ras] , phosphatidylinositol 3-kinase , the serine/threonine kinase Raf-1 , and the protein tyrosine phosphatase SHP-2 . Positive_regulation HRAS F2R 7679495 211263 Here we report that LPA and a agonist peptide rapidly *activate* the protooncogene product [p21ras] in quiescent fibroblasts . Positive_regulation HRAS FAS 9240472 445943 Osmotic cell shrinkage did not interfere with *induced* activation of the acidic sphingomyelinase or activation of [Ras] but impaired the formation of O2 suggesting an important function of cell volume in the synthesis of reactive oxygen intermediates upon Fas receptor ligation . Positive_regulation HRAS FAS 9642224 514307 In contrast , engagement , although *inducing* a vigorous and PKC independent activation of endogenous [p21(ras)] , did not alter cell cycle progression , nor did it require such progression for apoptosis . Positive_regulation HRAS FHL1 23456229 2781811 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Positive_regulation HRAS GPR115 9020193 412843 A scaffold for mediated [Ras] *activation* . Positive_regulation HRAS GPR132 9020193 412832 A scaffold for mediated [Ras] *activation* . Positive_regulation HRAS GPR87 9020193 412912 A scaffold for mediated [Ras] *activation* . Positive_regulation HRAS ITGB2 17624948 1770113 We have recently shown that Ras is also downstream of LFA-1 engagement : signaling through phospholipase D (PLD) to RasGRP1 was *required* for [Ras] activation on the plasma membrane following stimulation of TCR . Positive_regulation HRAS MAP2K6 10442634 635717 Finally , while Rlf-CAAX does not increase Erk activity , inhibition of *blocks* both [Ras-] as well as Rlf-CAAX induced differentiation , suggesting that RalGEFs induce PrE differentiation in a manner depending on basal MEK or Erk activity . Positive_regulation HRAS MAP2K6 10978313 751980 was *required* for [Ras] stimulation of the p38 pathway . Positive_regulation HRAS MAP2K6 12411397 1010754 PE and ET-1 do not activate protein kinase B but stimulate [Ras] and Erk , and their ability to activate protein synthesis was *blocked* by inhibition of Ras or and by rapamycin , which inhibits mTOR ( mammalian target of rapamycin ) . Positive_regulation HRAS MAP2K6 17226785 1696264 This follows a temporal sequence that involves [Ras-GTP] *activation* of , and is independent of PKC , Src , and PI3 kinase . Positive_regulation HRAS MAP2K6 19022560 2029197 Furthermore , *activation* of Raf-1 , and the ERKs by either EGF or [Ras] ( G12R ) was inhibited by NM23H2 overexpression . Positive_regulation HRAS MAP2K6 23546290 2763049 Second , farnesyltransferase inhibitor I , a [Ras] *inhibitor* , and U0126 , a inhibitor , induced an inhibition of the cell proliferation in C6 cells , while the cell proliferation was inhibited by nobiletin as well . Positive_regulation HRAS MAP2K6 8182145 256485 One of these pathways involves the activation of [Ras] , leading to the activation of Raf-1 , and the subsequent *activation* of ( MAPK or ERK kinase ) . Positive_regulation HRAS MAP2K6 8921960 396888 Shc is involved in *activation* of [p21ras] , a key event in the signaling cascade , via p72raf and , leading to MAP/Erk kinase (MAPK) activation . Positive_regulation HRAS MAP2K6 9135066 427690 Moreover , inhibition of endogenous by a specific inhibitor , PD 098059 , *suppressed* the activation of p96h2bk by oncogenic [Ras] . Positive_regulation HRAS MAP2K6 9484798 488162 ERK-2 is activated via a kinase cascade initiated by activation of the G protein [p21Ras] followed by phosphorylation and *activation* of Raf-1 and ( MEK-1 ) . Positive_regulation HRAS NGFR 8108130 246103 We have previously shown that nerve growth factor (NGF) induces a rapid and relatively continuous activation of Ras in rat pheochromocytoma PC12 cells while epidermal growth factor (EGF) activates Ras transiently , and that tyrosine kinase activity of the is *essential* for the activation of [Ras] ( Muroya et al. , Oncogene , 7 , 277-281 , 1992 ) . Positive_regulation HRAS S100B 21209080 2391857 The *dependent* activation of diaphanous-1/Rac1/JNK/AP-1 , Ras/Rac1/NF-?B and [Src/Ras/PI3K/RhoA/diaphanous-1] results in the up-regulation of expression of the chemokines , CCL3 , CCL5 , and CXCL12 , whose release and activity are required for S100B to stimulate microglia migration . Positive_regulation HRAS SELL 8986819 404097 Stimulation of the Ras pathway by L-selectin requires functional p56lck , since p56lck-deficient Jurkat cells ( JCaM1.6 ) do not show tyrosine phosphorylation , association of with Grb2/Sos , and *activation* of [Ras] upon L-selectin triggering . Positive_regulation HRAS TF 2031324 159566 To summarize , E [1A+c-Ha-ras] oncogene transformed REF can grow independently of GF but still *require* . Positive_regulation HRAS TNF 12600818 1085042 treatment *induced* both [Ras] and MEKK1 activation . Positive_regulation HRAS TNF 14999690 1216808 In conclusion , these data support the hypotheses that hepatocellular oxidative stress leads to cell death and that induced [Ras] *activation* is important in hepatic proliferation in response to ethanol induced liver injury . Positive_regulation HRAS TNF 17059425 1683925 Zoledronate reduced Ras prenylation , [Ras] and RhoA translocation to the membrane , and sustained ERK1/2 phosphorylation and *induced* JNK phosphorylation . Positive_regulation HRAS TNF 17994109 1851156 triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* [Ras] , p38 MAPK , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation HRAS TNF 18310456 1879061 Simvastatin potently suppressed TNF-alpha induced phosphorylation of ERK1/2 and SAPK/JNK by inhibiting *induced* membrane localization of [Ras] and RhoA . Positive_regulation HRAS TNF 21938476 2532759 With 4-MC pretreatment to hyperglycemic rats the following results were noted : ( i ) Decrease in pancreatic NGF level was blocked , ( ii ) Increase in pancreatic TNF-a level and the number of ( + ) beta cell in the islets were prevented , ( iii ) *Increase* in the number of ß cell synthhesized apoptotic [Ras] effectors that RASSF1 and NORE1 was blocked , ( iv ) While pancreatic lipid peroxidation level decreased , antioxidant molecule glutathione and antioxidant enzymes glutathione peroxidase , catalase and superoxide dismutase activities increased , ( v ) Pancreatic caspase-3 activity and the number of cleaved caspase-3 ( + ) ß cells were decreased . Positive_regulation HRAS TNF 8887541 391455 Moreover , RasN17 expression blocked *induced* [Ras-GTP] formation in L929 cells . Positive_regulation HRG EPHB2 12115729 964319 The activation of both and PI3-K was *essential* for [HRG] regulation of COXII , i.e. , blockage of either pathway eliminated HRG mediated alteration . Positive_regulation HRG EPHB2 17493932 1761640 Taken together , these findings clearly indicate that [HRG] *activation* of signaling modulates HAS phosphorylation/activation and HA production leading to CD44 mediated oncogenic events and ovarian cancer progression . Positive_regulation HRG IL1B 16357062 1553917 As with erbB3 phophorylation , IL-1beta stimulated both HRG-alpha and HRG-beta mRNA expression , as well as HRG release into gastric fibroblast CM. *stimulated* [HRG] expression and release were also inhibited by celecoxib , and exogenous PGE ( 2 ) restored this inhibitory effect , suggesting the activation of an IL-1beta-COX-2-PGE ( 2 ) pathway that culminates in the release of HRG from fibroblasts . Positive_regulation HRG MMP7 18600430 1972308 In this study , we show that [heregulin-beta (HRG-beta)] stimulation remarkably *induced* promoter activity and significantly enhanced the expression and activity of MMP-7 in MCF-7 cells overexpressing HER2 . Positive_regulation HRH1 AQP1 19443731 2107117 [Histamine H1 receptor] *induces* cytosolic calcium increase and translocation in human salivary gland cells . Positive_regulation HRH1 AQP10 19443731 2107115 [Histamine H1 receptor] *induces* cytosolic calcium increase and translocation in human salivary gland cells . Positive_regulation HRH1 AQP11 19443731 2107116 [Histamine H1 receptor] *induces* cytosolic calcium increase and translocation in human salivary gland cells . Positive_regulation HRH1 AQP2 19443731 2107118 [Histamine H1 receptor] *induces* cytosolic calcium increase and translocation in human salivary gland cells . Positive_regulation HRH1 AQP3 19443731 2107119 [Histamine H1 receptor] *induces* cytosolic calcium increase and translocation in human salivary gland cells . Positive_regulation HRH1 AQP4 19443731 2107120 [Histamine H1 receptor] *induces* cytosolic calcium increase and translocation in human salivary gland cells . Positive_regulation HRH1 AQP5 19443731 2107121 [Histamine H1 receptor] *induces* cytosolic calcium increase and translocation in human salivary gland cells . Positive_regulation HRH1 AQP6 19443731 2107122 [Histamine H1 receptor] *induces* cytosolic calcium increase and translocation in human salivary gland cells . Positive_regulation HRH1 AQP7 19443731 2107123 [Histamine H1 receptor] *induces* cytosolic calcium increase and translocation in human salivary gland cells . Positive_regulation HRH1 AQP8 19443731 2107124 [Histamine H1 receptor] *induces* cytosolic calcium increase and translocation in human salivary gland cells . Positive_regulation HRH1 AQP9 19443731 2107125 [Histamine H1 receptor] *induces* cytosolic calcium increase and translocation in human salivary gland cells . Positive_regulation HRH1 CSF2 15514212 1359719 Furthermore , the molecular mechanisms of *induced* HDC and [HH1R] expression in monocytic U937 cells were investigated . Positive_regulation HRH1 CSF2 15514212 1359721 In U937 cells , *enhanced* histamine secretion and gene expression of HDC and [HH1R] . Positive_regulation HRH1 CSF2 15514212 1359723 A promoter assay showed that *enhanced* gene transcription of HDC and [HH1R] but not HH2R . Positive_regulation HRH1 CSF2 15514212 1359729 The present results indicate that HDC and HHR are expressed in arteriosclerotic lesion , and that *induces* HDC and [HH1R] expression in monocytes . Positive_regulation HRH1 HDC 15514212 1359730 The present results indicate that and HHR are expressed in arteriosclerotic lesion , and that GM-CSF *induces* HDC and [HH1R] expression in monocytes . Positive_regulation HRH1 IL4 19596986 2112075 These results suggest that suplatast alleviates nasal symptoms by inhibiting histamine signaling in TDI sensitized rats through the suppression of histamine- and *induced* [H1R] gene expression by the inhibitions of HDC and IL-4 gene transcriptions , respectively . Positive_regulation HRH1 IL4 20112007 2242031 stimulation *increased* [H1R] protein levels and H1R mRNA levels . Positive_regulation HRH1 IL4 20112007 2242032 also *increased* [H1R] promoter activity , but had no effect on H1R mRNA stability , indicating that up-regulation of H1R was due to an increase in H1R mRNA synthesis . Positive_regulation HRH1 IL4 20112007 2242039 These results indicated that *up-regulated* [H1R] mRNA level through increased transcription of H1R gene via JAK3-STAT6 pathway . Positive_regulation HRH1 IL8 17959901 1814996 These results indicate that histamine *induces* production from gingival fibroblasts through [H1R] , and synergistically augments the inflammatory stimuli by amplification of the MAPK and NF-kappaB through H1R linked PLC . Positive_regulation HRH1 MAP2K1 21730054 2471495 U0126 , an inhibitor , and DPQ , a poly(ADP-ribose) polymerase-1 inhibitor , *suppressed* PMA induced up-regulation of [H1R] gene expression . Positive_regulation HRH1 MAP2K2 21730054 2471496 U0126 , an inhibitor , and DPQ , a poly(ADP-ribose) polymerase-1 inhibitor , *suppressed* PMA induced up-regulation of [H1R] gene expression . Positive_regulation HRH1 MAP2K3 21730054 2471497 U0126 , an inhibitor , and DPQ , a poly(ADP-ribose) polymerase-1 inhibitor , *suppressed* PMA induced up-regulation of [H1R] gene expression . Positive_regulation HRH1 MAP2K4 21730054 2471498 U0126 , an inhibitor , and DPQ , a poly(ADP-ribose) polymerase-1 inhibitor , *suppressed* PMA induced up-regulation of [H1R] gene expression . Positive_regulation HRH1 MAP2K5 21730054 2471499 U0126 , an inhibitor , and DPQ , a poly(ADP-ribose) polymerase-1 inhibitor , *suppressed* PMA induced up-regulation of [H1R] gene expression . Positive_regulation HRH1 MAP2K6 21730054 2471500 U0126 , an inhibitor , and DPQ , a poly(ADP-ribose) polymerase-1 inhibitor , *suppressed* PMA induced up-regulation of [H1R] gene expression . Positive_regulation HRH1 MAP2K7 21730054 2471501 U0126 , an inhibitor , and DPQ , a poly(ADP-ribose) polymerase-1 inhibitor , *suppressed* PMA induced up-regulation of [H1R] gene expression . Positive_regulation HRH1 MAPK1 11282781 799244 An inhibitor of NF-kappaB activation , pyrrolidine dithiocarbamate , and a p38 inhibitor , *blocked* the IL-1beta induced [H(1)R] desensitization , whereas anisomycin , an SAPK/JNK and p38 MAPK activator , mimicked the effect of IL-1beta . Positive_regulation HRH1 MAPK1 11282781 799258 Here , we have demonstrated that IL-1beta desensitizes [H(1)R] , which *involves* the activation of p38 and NF-kappaB , leading to the expression of cox-2 and the synthesis of PGE ( 2 ) . Positive_regulation HRH1 MAPK10 11282781 799245 An inhibitor of NF-kappaB activation , pyrrolidine dithiocarbamate , and a p38 inhibitor , *blocked* the IL-1beta induced [H(1)R] desensitization , whereas anisomycin , an SAPK/JNK and p38 MAPK activator , mimicked the effect of IL-1beta . Positive_regulation HRH1 MAPK10 11282781 799259 Here , we have demonstrated that IL-1beta desensitizes [H(1)R] , which *involves* the activation of p38 and NF-kappaB , leading to the expression of cox-2 and the synthesis of PGE ( 2 ) . Positive_regulation HRH1 MAPK11 11282781 799246 An inhibitor of NF-kappaB activation , pyrrolidine dithiocarbamate , and a p38 inhibitor , *blocked* the IL-1beta induced [H(1)R] desensitization , whereas anisomycin , an SAPK/JNK and p38 MAPK activator , mimicked the effect of IL-1beta . Positive_regulation HRH1 MAPK11 11282781 799260 Here , we have demonstrated that IL-1beta desensitizes [H(1)R] , which *involves* the activation of p38 and NF-kappaB , leading to the expression of cox-2 and the synthesis of PGE ( 2 ) . Positive_regulation HRH1 MAPK12 11282781 799247 An inhibitor of NF-kappaB activation , pyrrolidine dithiocarbamate , and a p38 inhibitor , *blocked* the IL-1beta induced [H(1)R] desensitization , whereas anisomycin , an SAPK/JNK and p38 MAPK activator , mimicked the effect of IL-1beta . Positive_regulation HRH1 MAPK12 11282781 799261 Here , we have demonstrated that IL-1beta desensitizes [H(1)R] , which *involves* the activation of p38 and NF-kappaB , leading to the expression of cox-2 and the synthesis of PGE ( 2 ) . Positive_regulation HRH1 MAPK13 11282781 799248 An inhibitor of NF-kappaB activation , pyrrolidine dithiocarbamate , and a p38 inhibitor , *blocked* the IL-1beta induced [H(1)R] desensitization , whereas anisomycin , an SAPK/JNK and p38 MAPK activator , mimicked the effect of IL-1beta . Positive_regulation HRH1 MAPK13 11282781 799262 Here , we have demonstrated that IL-1beta desensitizes [H(1)R] , which *involves* the activation of p38 and NF-kappaB , leading to the expression of cox-2 and the synthesis of PGE ( 2 ) . Positive_regulation HRH1 MAPK14 11282781 799249 An inhibitor of NF-kappaB activation , pyrrolidine dithiocarbamate , and a p38 inhibitor , *blocked* the IL-1beta induced [H(1)R] desensitization , whereas anisomycin , an SAPK/JNK and p38 MAPK activator , mimicked the effect of IL-1beta . Positive_regulation HRH1 MAPK14 11282781 799263 Here , we have demonstrated that IL-1beta desensitizes [H(1)R] , which *involves* the activation of p38 and NF-kappaB , leading to the expression of cox-2 and the synthesis of PGE ( 2 ) . Positive_regulation HRH1 MAPK15 11282781 799243 An inhibitor of NF-kappaB activation , pyrrolidine dithiocarbamate , and a p38 inhibitor , *blocked* the IL-1beta induced [H(1)R] desensitization , whereas anisomycin , an SAPK/JNK and p38 MAPK activator , mimicked the effect of IL-1beta . Positive_regulation HRH1 MAPK15 11282781 799257 Here , we have demonstrated that IL-1beta desensitizes [H(1)R] , which *involves* the activation of p38 and NF-kappaB , leading to the expression of cox-2 and the synthesis of PGE ( 2 ) . Positive_regulation HRH1 MAPK3 11282781 799250 An inhibitor of NF-kappaB activation , pyrrolidine dithiocarbamate , and a p38 inhibitor , *blocked* the IL-1beta induced [H(1)R] desensitization , whereas anisomycin , an SAPK/JNK and p38 MAPK activator , mimicked the effect of IL-1beta . Positive_regulation HRH1 MAPK3 11282781 799264 Here , we have demonstrated that IL-1beta desensitizes [H(1)R] , which *involves* the activation of p38 and NF-kappaB , leading to the expression of cox-2 and the synthesis of PGE ( 2 ) . Positive_regulation HRH1 MAPK4 11282781 799251 An inhibitor of NF-kappaB activation , pyrrolidine dithiocarbamate , and a p38 inhibitor , *blocked* the IL-1beta induced [H(1)R] desensitization , whereas anisomycin , an SAPK/JNK and p38 MAPK activator , mimicked the effect of IL-1beta . Positive_regulation HRH1 MAPK4 11282781 799265 Here , we have demonstrated that IL-1beta desensitizes [H(1)R] , which *involves* the activation of p38 and NF-kappaB , leading to the expression of cox-2 and the synthesis of PGE ( 2 ) . Positive_regulation HRH1 MAPK6 11282781 799252 An inhibitor of NF-kappaB activation , pyrrolidine dithiocarbamate , and a p38 inhibitor , *blocked* the IL-1beta induced [H(1)R] desensitization , whereas anisomycin , an SAPK/JNK and p38 MAPK activator , mimicked the effect of IL-1beta . Positive_regulation HRH1 MAPK6 11282781 799266 Here , we have demonstrated that IL-1beta desensitizes [H(1)R] , which *involves* the activation of p38 and NF-kappaB , leading to the expression of cox-2 and the synthesis of PGE ( 2 ) . Positive_regulation HRH1 MAPK7 11282781 799253 An inhibitor of NF-kappaB activation , pyrrolidine dithiocarbamate , and a p38 inhibitor , *blocked* the IL-1beta induced [H(1)R] desensitization , whereas anisomycin , an SAPK/JNK and p38 MAPK activator , mimicked the effect of IL-1beta . Positive_regulation HRH1 MAPK7 11282781 799267 Here , we have demonstrated that IL-1beta desensitizes [H(1)R] , which *involves* the activation of p38 and NF-kappaB , leading to the expression of cox-2 and the synthesis of PGE ( 2 ) . Positive_regulation HRH1 MAPK8 11282781 799254 An inhibitor of NF-kappaB activation , pyrrolidine dithiocarbamate , and a p38 inhibitor , *blocked* the IL-1beta induced [H(1)R] desensitization , whereas anisomycin , an SAPK/JNK and p38 MAPK activator , mimicked the effect of IL-1beta . Positive_regulation HRH1 MAPK8 11282781 799268 Here , we have demonstrated that IL-1beta desensitizes [H(1)R] , which *involves* the activation of p38 and NF-kappaB , leading to the expression of cox-2 and the synthesis of PGE ( 2 ) . Positive_regulation HRH1 MAPK9 11282781 799255 An inhibitor of NF-kappaB activation , pyrrolidine dithiocarbamate , and a p38 inhibitor , *blocked* the IL-1beta induced [H(1)R] desensitization , whereas anisomycin , an SAPK/JNK and p38 MAPK activator , mimicked the effect of IL-1beta . Positive_regulation HRH1 MAPK9 11282781 799269 Here , we have demonstrated that IL-1beta desensitizes [H(1)R] , which *involves* the activation of p38 and NF-kappaB , leading to the expression of cox-2 and the synthesis of PGE ( 2 ) . Positive_regulation HRH1 NFKB1 11282781 799270 Here , we have demonstrated that IL-1beta desensitizes [H(1)R] , which *involves* the activation of p38 MAPK and , leading to the expression of cox-2 and the synthesis of PGE ( 2 ) . Positive_regulation HRH1 PARP1 21730054 2471494 U0126 , an MEK inhibitor , and DPQ , a inhibitor , *suppressed* PMA induced up-regulation of [H1R] gene expression . Positive_regulation HRH1 POLDIP2 11282781 799242 An inhibitor of NF-kappaB activation , pyrrolidine dithiocarbamate , and a MAPK inhibitor , *blocked* the IL-1beta induced [H(1)R] desensitization , whereas anisomycin , an SAPK/JNK and p38 MAPK activator , mimicked the effect of IL-1beta . Positive_regulation HRH1 PRKACB 15107586 1240612 Heterologous [H1R] down-regulation was significantly reversed in the *presence* of the cyclic AMP dependent inhibitor KT5720 . Positive_regulation HRH1 PRKACB 15107586 1240618 however , a inhibitor did not *inhibit* heterologous [H1R] phosphorylation . Positive_regulation HRH1 PRKACG 15107586 1240613 Heterologous [H1R] down-regulation was significantly reversed in the *presence* of the cyclic AMP dependent inhibitor KT5720 . Positive_regulation HRH1 PRKACG 15107586 1240619 however , a inhibitor did not *inhibit* heterologous [H1R] phosphorylation . Positive_regulation HRH1 PRKAR1A 15107586 1240614 Heterologous [H1R] down-regulation was significantly reversed in the *presence* of the cyclic AMP dependent inhibitor KT5720 . Positive_regulation HRH1 PRKAR1A 15107586 1240620 however , a inhibitor did not *inhibit* heterologous [H1R] phosphorylation . Positive_regulation HRH1 PRKAR1B 15107586 1240615 Heterologous [H1R] down-regulation was significantly reversed in the *presence* of the cyclic AMP dependent inhibitor KT5720 . Positive_regulation HRH1 PRKAR1B 15107586 1240621 however , a inhibitor did not *inhibit* heterologous [H1R] phosphorylation . Positive_regulation HRH1 PRKAR2A 15107586 1240616 Heterologous [H1R] down-regulation was significantly reversed in the *presence* of the cyclic AMP dependent inhibitor KT5720 . Positive_regulation HRH1 PRKAR2A 15107586 1240622 however , a inhibitor did not *inhibit* heterologous [H1R] phosphorylation . Positive_regulation HRH1 PRKAR2B 15107586 1240617 Heterologous [H1R] down-regulation was significantly reversed in the *presence* of the cyclic AMP dependent inhibitor KT5720 . Positive_regulation HRH1 PRKAR2B 15107586 1240623 however , a inhibitor did not *inhibit* heterologous [H1R] phosphorylation . Positive_regulation HRH1 RELA 11282781 799271 Here , we have demonstrated that IL-1beta desensitizes [H(1)R] , which *involves* the activation of p38 MAPK and , leading to the expression of cox-2 and the synthesis of PGE ( 2 ) . Positive_regulation HRH1 VDR 17547532 1784217 RT-PCR , electromotility shift , siRNA inhibition assays , and chromatin immunoprecipitation assays were used to analyze the *role* of in activation of DPT and [HRH1] during differentiation . Positive_regulation HSD11B1 HSD11B2 9141556 428426 The preference of D for the reductase reaction in human kidney slices is probably caused by the fluor atom in position 9 , is catalyzed by <11beta-HSD-II> , and *leads* to an activation of [11-DH-D] to D in the human kidney . Positive_regulation HSD11B1 IL1B 10588815 572148 ( 0.05-50 ng/ml ) *stimulated* [11betaHSD1] mRNA expression in a dose related manner , both in the absence and in the presence of rhLH ( 3 ng/ml ) . Positive_regulation HSD11B1 IL1B 10588815 572149 We conclude that [11betaHSD1] mRNA expression in functionally mature granulosa cells is directly *stimulated* by gonadotrophins and in vitro , potentially involving post-receptor signalling via PKA- and PKC mediated pathways . Positive_regulation HSD11B1 TNF 19088256 2024381 To dissect the molecular mechanism of this increase , we investigated basal and *induced* transcription of the 11beta-HSD1 gene ( [HSD11B1] ) in HepG2 cells . Positive_regulation HSD11B1 TNF 19088256 2024386 Gel shift and RNA interference assays revealed the involvement of mainly C/EBPalpha , but also C/EBPbeta , in basal and only of C/EBPbeta in the *induced* [HSD11B1] expression . Positive_regulation HSD11B2 ADCY1 9623596 511005 Activation of by forskolin ( 100 microM ) *up-regulated* both [11beta-HSD2] activity and mRNA expression ; Positive_regulation HSD11B2 ADCY10 9623596 511004 Activation of by forskolin ( 100 microM ) *up-regulated* both [11beta-HSD2] activity and mRNA expression ; Positive_regulation HSD11B2 ADCY2 9623596 511006 Activation of by forskolin ( 100 microM ) *up-regulated* both [11beta-HSD2] activity and mRNA expression ; Positive_regulation HSD11B2 ADCY3 9623596 511007 Activation of by forskolin ( 100 microM ) *up-regulated* both [11beta-HSD2] activity and mRNA expression ; Positive_regulation HSD11B2 ADCY4 9623596 511008 Activation of by forskolin ( 100 microM ) *up-regulated* both [11beta-HSD2] activity and mRNA expression ; Positive_regulation HSD11B2 ADCY5 9623596 511009 Activation of by forskolin ( 100 microM ) *up-regulated* both [11beta-HSD2] activity and mRNA expression ; Positive_regulation HSD11B2 ADCY6 9623596 511010 Activation of by forskolin ( 100 microM ) *up-regulated* both [11beta-HSD2] activity and mRNA expression ; Positive_regulation HSD11B2 ADCY7 9623596 511011 Activation of by forskolin ( 100 microM ) *up-regulated* both [11beta-HSD2] activity and mRNA expression ; Positive_regulation HSD11B2 ADCY8 9623596 511012 Activation of by forskolin ( 100 microM ) *up-regulated* both [11beta-HSD2] activity and mRNA expression ; Positive_regulation HSD11B2 ADCY9 9623596 511013 Activation of by forskolin ( 100 microM ) *up-regulated* both [11beta-HSD2] activity and mRNA expression ; Positive_regulation HSD11B2 ANGPT2 12911547 1122118 Therefore , we hypothesized that *regulates* [11beta-HSD2] . Positive_regulation HSD11B2 AVP 16109662 1445284 may *act* as a synergistic hormone in aldosterone mediated [11beta-HSD2] induction . Positive_regulation HSD11B2 CD4 15634910 1362655 Activation of ( + ) T cells *increased* their [11beta-HSD1] activity , as did their polarization into Th1 or Th2 cells . Positive_regulation HSD11B2 CEBPA 10906322 730783 Here we demonstrate that is a potent *activator* of the [11beta-HSD1] gene in hepatoma cells and that mice deficient in C/EBPalpha have reduced hepatic 11beta-HSD1 expression . Positive_regulation HSD11B2 CEBPA 16543369 1561921 These results therefore demonstrate tissue-specific differential regulation of 11beta-HSD1 mRNA through alternate promoter usage and suggest that increased adipose [11beta-HSD1] expression in obesity is *due* to a selective increase in activity of the regulated P2 promoter . Positive_regulation HSD11B2 CEBPA 17951535 1814503 In conclusion , we demonstrated that GR and were *involved* in cortisol induced [11beta-HSD1] mRNA expression via binding to 11beta-HSD1 promoter in amnion fibroblasts , which may cast a feed-forward production of cortisol in the fetal membranes at the end of gestation . Positive_regulation HSD11B2 CEBPA 18032797 1852111 It was found that ( C/EBP-alpha ) and C/EBP-beta *regulated* [HSD11B2] transcription and that DHEA likely modulated the transcription of 11beta-HSD2 in a phosphatidylinositol-3 kinase/Akt dependent manner by increasing C/EBP-beta mRNA and protein expression . Positive_regulation HSD11B2 CEBPA 18032797 1852120 Moreover , it is shown that and C/EBP-beta differentially *regulate* the expression of [11beta-HSD1] and 11beta-HSD2 . Positive_regulation HSD11B2 CEBPB 10906322 730785 In contrast , is a relatively weak *activator* of [11beta-HSD1] transcription in hepatoma cells and attenuates C/EBPalpha induction , and mice that lack C/EBPbeta have increased hepatic 11beta-HSD1 mRNA . Positive_regulation HSD11B2 CEBPB 18032797 1852112 It was found that CCAAT/enhancer binding protein-alpha ( C/EBP-alpha ) and *regulated* [HSD11B2] transcription and that DHEA likely modulated the transcription of 11beta-HSD2 in a phosphatidylinositol-3 kinase/Akt dependent manner by increasing C/EBP-beta mRNA and protein expression . Positive_regulation HSD11B2 CEBPB 18032797 1852121 Moreover , it is shown that C/EBP-alpha and differentially *regulate* the expression of [11beta-HSD1] and 11beta-HSD2 . Positive_regulation HSD11B2 CEBPB 19088256 2024391 In conclusion , C/EBPalpha and control basal transcription , and TNF-alpha *upregulates* [11beta-HSD1] , most likely by p38 MAPK mediated increased binding of C/EBPbeta to the human HSD11B1 promoter . Positive_regulation HSD11B2 CORT 15761036 1403581 The inhibition of either [11beta HSD1] or 11beta HSD2 significantly lowered testosterone production in the *presence* of . Positive_regulation HSD11B2 CORT 17592030 1764613 Despite lower basal expression of 11beta-hydroxysteroid dehydrogenase type 1 ( 11beta-HSD1 ) , which generates active glucocorticoids within cells , *mediated* induction of [11beta-HSD1] mRNA levels was more pronounced in adipose tissues of Pomc-/- mice . Positive_regulation HSD11B2 CRH 22971074 2693527 *stimulates* expression of leptin , [11beta-HSD2] and syncytin-1 in primary human trophoblasts . Positive_regulation HSD11B2 CRH 22971074 2693534 The *induction* of leptin and [11beta-HSD2] in the syncytiotrophoblast by might promote fetal nutrient supply and placental corticosteroid metabolism in the phase before labour induction . Positive_regulation HSD11B2 EGF 8977399 408783 However , *stimulated* [11 beta-HSD] reductive activity in cultured Leydig cells from both control ( from 18.97 +/- 1.10 to 27.16 +/- 0.71 pmol/h.10 ( 6 ) cells and ADX rats ( from 16.51 +/- 0.75 to 23.56 +/- 0.84 pmol/h.10 ( 6 ) cells ) . Positive_regulation HSD11B2 EGR1 12626438 1079882 Overexpression of *reduced* endogenous [11beta-HSD2] activity in LLC-PK1 cells , indicating that MAPK ERK is involved in the regulation of 11beta-HSD2 in vitro . Positive_regulation HSD11B2 EGR1 18692075 1961237 In contrast , the transcriptional activity of [11beta-HSD-2] was decreased during the same stimuli , and another inflammation induced transcription factor might have *mediated* the effect by interfering with the effect of Sp1 , which maintains the basal expression of 11beta-HSD-2 . Positive_regulation HSD11B2 EPHB2 12626438 1079883 Overexpression of Egr-1 reduced endogenous 11beta-HSD2 activity in LLC-PK1 cells , indicating that MAPK is *involved* in the regulation of [11beta-HSD2] in vitro . Positive_regulation HSD11B2 GCA 10624835 658494 In the present study , various steroid hormones or , given for 1 week , or thyroxine given for 5 weeks to normal intact rats *had* different effects on the [11beta-HSD] oxidative activity in testis and liver . Positive_regulation HSD11B2 IGF1 10566668 567490 Neither nor GH *had* any effect on [11betaHSD2] activity . Positive_regulation HSD11B2 IGF1 8713094 373597 In 2S FAZA cells [11 beta-HSD] 1 activity and mRNA expression are *regulated* by hormones , with dexamethasone increasing activity and insulin , forskolin and decreasing it . Positive_regulation HSD11B2 IL1A 15866114 1401602 In JEG-3 cells , [11beta HSD-1] 32-kd expression was *increased* with and tumor necrosis factor alpha (TNF-alpha) , while 11beta HSD-2 expression was unaffected . Positive_regulation HSD11B2 IL1B 11393780 823104 In MG-63 cells , and tumor necrosis factor alpha (TNF-alpha) potently *inhibited* [11beta-HSD2] activity ( cortisol-cortisone conversion ) and messenger RNA ( mRNA ) levels in a dose dependent manner while stimulating reciprocal expression of 11beta-HSD1 mRNA and activity ( cortisone-cortisol conversion ) . Positive_regulation HSD11B2 IL1B 12519881 1047755 also *up-regulated* [11 beta-HSD-1] activity maximally at 0.6 x 10 ( -9 ) M ( 160 +/- 33 % ; Positive_regulation HSD11B2 IL1B 16469798 1548303 Using real-time PCR and enzyme activity assay , we found that cortisol ( 1 mum ) and ( 10 ng/ml ) for 24 h significantly *increased* [11beta-HSD1] mRNA expression and reductase activity in cultured human chorionic trophoblasts . Positive_regulation HSD11B2 IL1B 16469798 1548304 We conclude that cortisol up-regulates [11beta-HSD1] expression through induction of promoter activity , and the effect was *enhanced* by , suggesting that more biologically active glucocorticoids could be generated in the fetal membranes in the presence of infection , which may consequently feed forward in up-regulation of prostaglandin synthesis . Positive_regulation HSD11B2 IL1B 18840637 2012918 The *induction* of [11beta-HSD1] by was further increased by cortisol , whereas the induction of cyclooxygenase 2 by IL-1beta was inhibited by cortisol . Positive_regulation HSD11B2 IL1B 18840637 2012921 Global inhibition of CCAAT-enhancer binding proteins ( C/EBPs ) with transfection of C/EBP-specific dominant negative expression plasmid could attenuate the *induction* of [11beta-HSD1] by , suggesting that C/EBPs may mediate the induction of 11beta-HSD1 by IL-1beta . Positive_regulation HSD11B2 IL1B 19776225 2232012 In 3T3-L1 preadipocytes , the level of mRNA and reductase activity of [11 beta-HSD1] was *augmented* by TNF-alpha , , and LPS , with a concomitant increase in inducible nitric oxide synthase (iNOS) , monocyte chemoattractant protein-1 ( MCP-1 ) , or IL-6 secretion . Positive_regulation HSD11B2 INS 10762282 683729 In view of the stimulatory effects of insulin and cortisol on adipogenesis , long-term *stimulation* of [11betaHSD] reductase activity by could aggravate visceral obesity . Positive_regulation HSD11B2 INS 18467433 1938867 In contrast , both and dexamethasone *augmented* [11beta-HSD1] activity and expression in rat white adipose tissue in vivo , thus confirming the role of insulin but revealing a fundamental difference regarding the role of dexamethasone in regulating adipocyte 11beta-HSD1 between the two model systems . Positive_regulation HSD11B2 INS 9399631 469189 It is being concluded , that both glucocorticoids and mineralocorticoids but not or triiodothyronine *induce* intestinal [11betaHSD] activity . Positive_regulation HSD11B2 JAK1 18378698 1907004 The inhibitor , as well as expression of dominant negative STAT5A , *impairs* hormone induction of [11beta-HSD2] . Positive_regulation HSD11B2 JAK2 18378698 1907005 The inhibitor , as well as expression of dominant negative STAT5A , *impairs* hormone induction of [11beta-HSD2] . Positive_regulation HSD11B2 JAK3 18378698 1907006 The inhibitor , as well as expression of dominant negative STAT5A , *impairs* hormone induction of [11beta-HSD2] . Positive_regulation HSD11B2 LEP 22971074 2693531 We hypothesized that CRH might attenuate syncytialisation , *induce* , and reduce [11beta-HSD2] expression in primary villous trophoblasts , which are known features of IUGR . Positive_regulation HSD11B2 MAP2K1 11696370 877501 Overexpression of , an ERK activator , *down-regulated* the [11beta-HSD2] activity . Positive_regulation HSD11B2 MAPK1 19497972 2120598 We showed that inhibition of p38 with the pharmacological inhibitor SB202190 *led* to an approximately 50 % reduction in [11beta-HSD2] activity , protein , and mRNA in primary human placental trophoblast cells . Positive_regulation HSD11B2 MAPK1 19497972 2120611 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Positive_regulation HSD11B2 MAPK10 19497972 2120599 We showed that inhibition of p38 with the pharmacological inhibitor SB202190 *led* to an approximately 50 % reduction in [11beta-HSD2] activity , protein , and mRNA in primary human placental trophoblast cells . Positive_regulation HSD11B2 MAPK10 19497972 2120612 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Positive_regulation HSD11B2 MAPK11 19497972 2120600 We showed that inhibition of p38 with the pharmacological inhibitor SB202190 *led* to an approximately 50 % reduction in [11beta-HSD2] activity , protein , and mRNA in primary human placental trophoblast cells . Positive_regulation HSD11B2 MAPK11 19497972 2120613 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Positive_regulation HSD11B2 MAPK12 19497972 2120601 We showed that inhibition of p38 with the pharmacological inhibitor SB202190 *led* to an approximately 50 % reduction in [11beta-HSD2] activity , protein , and mRNA in primary human placental trophoblast cells . Positive_regulation HSD11B2 MAPK12 19497972 2120614 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Positive_regulation HSD11B2 MAPK13 19497972 2120602 We showed that inhibition of p38 with the pharmacological inhibitor SB202190 *led* to an approximately 50 % reduction in [11beta-HSD2] activity , protein , and mRNA in primary human placental trophoblast cells . Positive_regulation HSD11B2 MAPK13 19497972 2120615 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Positive_regulation HSD11B2 MAPK14 19497972 2120603 We showed that inhibition of p38 with the pharmacological inhibitor SB202190 *led* to an approximately 50 % reduction in [11beta-HSD2] activity , protein , and mRNA in primary human placental trophoblast cells . Positive_regulation HSD11B2 MAPK14 19497972 2120616 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Positive_regulation HSD11B2 MAPK15 19497972 2120597 We showed that inhibition of p38 with the pharmacological inhibitor SB202190 *led* to an approximately 50 % reduction in [11beta-HSD2] activity , protein , and mRNA in primary human placental trophoblast cells . Positive_regulation HSD11B2 MAPK15 19497972 2120610 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Positive_regulation HSD11B2 MAPK3 19497972 2120604 We showed that inhibition of p38 with the pharmacological inhibitor SB202190 *led* to an approximately 50 % reduction in [11beta-HSD2] activity , protein , and mRNA in primary human placental trophoblast cells . Positive_regulation HSD11B2 MAPK3 19497972 2120617 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Positive_regulation HSD11B2 MAPK3 23966319 2850442 Furthermore , U0126 increased the HSD11B2 promoter activity by 300 % , indicating that *regulates* placental [11beta-HSD2] expression through a transcriptional mechanism . Positive_regulation HSD11B2 MAPK4 19497972 2120605 We showed that inhibition of p38 with the pharmacological inhibitor SB202190 *led* to an approximately 50 % reduction in [11beta-HSD2] activity , protein , and mRNA in primary human placental trophoblast cells . Positive_regulation HSD11B2 MAPK4 19497972 2120618 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Positive_regulation HSD11B2 MAPK6 19497972 2120606 We showed that inhibition of p38 with the pharmacological inhibitor SB202190 *led* to an approximately 50 % reduction in [11beta-HSD2] activity , protein , and mRNA in primary human placental trophoblast cells . Positive_regulation HSD11B2 MAPK6 19497972 2120619 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Positive_regulation HSD11B2 MAPK7 19497972 2120607 We showed that inhibition of p38 with the pharmacological inhibitor SB202190 *led* to an approximately 50 % reduction in [11beta-HSD2] activity , protein , and mRNA in primary human placental trophoblast cells . Positive_regulation HSD11B2 MAPK7 19497972 2120620 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Positive_regulation HSD11B2 MAPK8 19497972 2120608 We showed that inhibition of p38 with the pharmacological inhibitor SB202190 *led* to an approximately 50 % reduction in [11beta-HSD2] activity , protein , and mRNA in primary human placental trophoblast cells . Positive_regulation HSD11B2 MAPK8 19497972 2120621 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Positive_regulation HSD11B2 MAPK9 19497972 2120609 We showed that inhibition of p38 with the pharmacological inhibitor SB202190 *led* to an approximately 50 % reduction in [11beta-HSD2] activity , protein , and mRNA in primary human placental trophoblast cells . Positive_regulation HSD11B2 MAPK9 19497972 2120622 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Positive_regulation HSD11B2 SOAT1 18378698 1907003 The inhibitor , as well as expression of dominant negative STAT5A , *impairs* hormone induction of [11beta-HSD2] . Positive_regulation HSD11B2 TNF 11393780 823103 In MG-63 cells , interleukin-1beta (IL-1beta) and potently *inhibited* [11beta-HSD2] activity ( cortisol-cortisone conversion ) and messenger RNA ( mRNA ) levels in a dose dependent manner while stimulating reciprocal expression of 11beta-HSD1 mRNA and activity ( cortisone-cortisol conversion ) . Positive_regulation HSD11B2 TNF 12519881 1047754 *up-regulated* [11 beta-HSD-1] activity maximally at 0.6 x 10 ( -9 ) M ( 140 +/- 20 % ; Positive_regulation HSD11B2 TNF 15866114 1401601 In JEG-3 cells , [11beta HSD-1] 32-kd expression was *increased* with interleukin (IL)-1beta and , while 11beta HSD-2 expression was unaffected . Positive_regulation HSD11B2 TNF 18692075 1961236 Interestingly , the transcriptional activity of [11beta-HSD-1] was *stimulated* by a representative proinflammatory cytokine , and inflammation related inducible transcription factors AP1 and C/EBPs might have been at least partly responsible for the effect . Positive_regulation HSD11B2 TNF 19088256 2024382 To dissect the molecular mechanism of this increase , we investigated basal and *induced* transcription of the [11beta-HSD1] gene ( HSD11B1 ) in HepG2 cells . Positive_regulation HSD11B2 TNF 19088256 2024390 In conclusion , C/EBPalpha and C/EBPbeta control basal transcription , and *upregulates* [11beta-HSD1] , most likely by p38 MAPK mediated increased binding of C/EBPbeta to the human HSD11B1 promoter . Positive_regulation HSD11B2 TNF 19088256 2024392 To our knowledge , this is the first study showing involvement of p38 MAPK in the TNF-alpha mediated [11beta-HSD1] regulation , and that *stimulates* enzyme activity in vivo . Positive_regulation HSD11B2 TNF 19776225 2232011 In 3T3-L1 preadipocytes , the level of mRNA and reductase activity of [11 beta-HSD1] was *augmented* by , IL-1 beta , and LPS , with a concomitant increase in inducible nitric oxide synthase (iNOS) , monocyte chemoattractant protein-1 ( MCP-1 ) , or IL-6 secretion . Positive_regulation HSD11B2 UGCG 10727009 677759 The metabolic *activation* of by [11beta-HSD] could possibly lead to an excess of GCS in the hepatocytes . Positive_regulation HSD17B1 IL1B 9603242 506769 In contrast , markedly *stimulated* both control and FSH supported [20alpha-hydroxysteroid dehydrogenase] activity ( 4.8- and 3.3-fold , respectively ) and transcripts ( 16.4- and 7.5-fold , respectively ) . Positive_regulation HSD17B11 HSD17B10 20638476 2322035 Ectopic expression of C/EBPa or C/EBPß in HepG2 cells showed that [HSD17B11] expression was *induced* by both transcription factors while expression was only induced by C/EBPß . Positive_regulation HSD17B11 SP1 21549806 2440464 These results show that [HSD17B11] transcription in PC cells is *regulated* by and C/EBPa . Positive_regulation HSD17B12 GRIK2 22522402 2658618 Conversely , phosphorylation of at serine 868 in the absence of SUMOylation *led* to an increase in [KAR] surface expression by facilitating receptor recycling between endosomal compartments and the plasma membrane . Positive_regulation HSP90AA1 EPHB2 14708611 1181155 Inhibition of , Src , or Akt *suppressed* [telomerase] activity in HSC-1 cells , but to a lesser extent than did treatment with AG 1478 . Positive_regulation HSP90AA1 EPHB2 15360086 1293610 The [Hsp90] chaperone complex inhibitor , radicicol , potentiated heat induced cellular killing , and inhibition of p42/p44 and Akt activation rather than modification of Hsp expression might be *involved* in enhancing cellular thermosensitivity . Positive_regulation HSP90AA1 EPHB2 18281615 1911673 Analysis of the expression of [HSP90] and *activation* of the downstream signaling of B-Raf was performed by Western blot . Positive_regulation HSP90AA1 ID1 10449746 637378 We demonstrate that ectopic expression of *leads* to activation of [telomerase] activity and immortalization of primary human keratinocytes . Positive_regulation HSP90AA1 ID1 10908559 722493 Under these experimental conditions , expression did not *trigger* induction of [telomerase] activity , and there was progressive shortening of the telomeres that was accompanied by elevated p16 levels and prevalence of active Rb . Positive_regulation HSP90AA1 IFI27 14612944 1163398 Overexpression of *suppressed* [telomerase] activity in tumor cells . Positive_regulation HSP90AA1 MAP2K6 18281615 1911679 Analysis of the expression of [HSP90] and *activation* of the downstream signaling of B-Raf was performed by Western blot . Positive_regulation HSP90AA1 RARB 14586406 1159578 Our previous work showed that acquisition of immortality at the dysplasia stage of oral cancer progression was consistently associated with four changes : loss of and p16INK4A expression , p53 mutations and *activation* of [telomerase] . Positive_regulation HSP90AA1 TNF 11864612 917598 induced recruitment and activation of the IKK complex *require* Cdc37 and [Hsp90] . Positive_regulation HSP90AA1 TNF 15020249 1221503 *induces* rapid activation and nuclear translocation of [telomerase] in human lymphocytes . Positive_regulation HSP90AA1 TNF 15020249 1221518 In this study , we show that tumor necrosis factor alpha (TNFalpha) induces telomerase activity in the cytoplasm of peripheral blood lymphocytes ( PBL ) at 60 min , followed by translocation of activated telomerase to the nucleus at 120 min. Conversely , the phosphoinositol 3-kinase (PI3K) inhibitor wortmannin blocks *induced* activation of [telomerase] , whereas the specific NF-kappaB translocation inhibitor SN-50 blocks TNFalpha induced nuclear translocation of activated telomerase . Positive_regulation HSP90AA1 TNF 15326480 1296863 The present study described that , in the leukemic KG1 cells , *induced* no apoptosis but a senescence state characterized by prolonged growth arrest , increased beta-galactosidase activity , p21WAF-1 induction , decreased [telomerase] activity , telomeric disturbances ( shortening , losses , fusions ) , and additional chromosomal aberrations . Positive_regulation HSP90AA1 TNF 19299722 2051940 Here , we show that modulation of levels in long-term cultures of human CD8 ( + ) T lymphocytes , by chronic exposure either to a neutralizing Ab or to an inhibitor of the TNF-alpha receptor-1 , increases proliferative potential , delays loss of CD28 expression , retards cytokine profile changes , and *enhances* [telomerase] activity . Positive_regulation HSP90AA1 TNFSF10 12460647 1021913 treatment does not *induce* HSP27 , HSP70 , or [HSP90] levels . Positive_regulation HSP90AA1 ZFP57 20235149 2244383 Constitutive expression of in C2C12 myoblasts *increased* mTERT expression and [telomerase] activity , and promoted the progression of the cell cycle and cell proliferation . Positive_regulation HSP90B1 CAPN8 16920763 1626758 THAPS at 5 microM significantly induced GRP94 , while 20 mmicroM caused a *dependent* cleavage of [GRP94] . Positive_regulation HSPA1A TNF 24041570 2888205 The [Hspa1a] expression was *augmented* by ( tumor necrosis factor-alpha ) and forskolin in NF-?B and CREB dependent manners , respectively . Positive_regulation HSPA5 CAPN8 16920763 1626786 Inhibition of *blocked* the induction of [GRP78] following exposure to RCTs suggesting that calpain was contributing to the observed ER stress following RCTs . Positive_regulation HSPA5 CD14 14516777 1147170 *dependent* regulation of [Grp78] in the liver and lungs of mice after burn injury . Positive_regulation HSPA5 CLU 23457489 2749514 Knockdown of CLU expression in SMMC7721 and HCCLM3 cells inhibited GRP78 expression after TN treatment and enhanced ER stress induced apoptosis , whereas over-expression of in HepG2 cells *increased* [GRP78] expression after TN induction and abolished the effect of TN on cell apoptosis . Positive_regulation HSPA5 EPHB2 17341418 1726746 Selective inhibitors of , p38 MAPK , and JNK *suppressed* the induction of [GRP78] , CHOP , and PPAR-beta , attenuated indomethacin induced cytotoxicity and reduced increased caspase activity . Positive_regulation HSPA5 EPHB2 17942905 1814137 Inhibition of also *resulted* in down-regulation of [GRP78] , which was physically associated with caspase-4 , before and after treatment with tunicamycin or thapsigargin . Positive_regulation HSPA5 EPHB2 18829155 2012766 Thus , activation of by ER stress is *necessary* for induction of [GRP78] that protects against apoptosis in gastric cancer cells submitted to ER stress . Positive_regulation HSPA5 MAP2K6 17942905 1814143 Inhibition of also *resulted* in down-regulation of [GRP78] , which was physically associated with caspase-4 , before and after treatment with tunicamycin or thapsigargin . Positive_regulation HSPA5 MAP2K6 18829155 2012772 Thus , activation of by ER stress is *necessary* for induction of [GRP78] that protects against apoptosis in gastric cancer cells submitted to ER stress . Positive_regulation HSPA5 PLAT 2460739 98588 The expression of variant *resulted* in elevated levels of [GRP78] and its stable association with tPA . Positive_regulation HSPA5 TNF 20650266 2340537 In contrast , IFN-? or *had* no effect on [Grp78] expression . Positive_regulation HSPA5 TNF 22319522 2553781 PTX ( 1 mM ) reduced *induced* activation of [GRP78] , p-eIF2 , ATF4 , IRE1a , and CHOP in vitro . Positive_regulation HSPA8 IL1B 10867521 706486 We suggest that the increased [HSP 72/73] expression of MC during peritonitis is in part *induced* by TNF-alpha and and may exert a cell-protective function , lessening MC damage during peritonitis . Positive_regulation HSPA8 TNF 10867521 706485 We suggest that the increased [HSP 72/73] expression of MC during peritonitis is in part *induced* by and IL-1beta and may exert a cell-protective function , lessening MC damage during peritonitis . Positive_regulation HSPA9 IL1B 15621568 1348896 In islets from two rat strains with different sensitivity to the toxic effects of cytokines we observed a significant difference in *mediated* [mortalin] expression . Positive_regulation HSPB1 DAPK1 24814693 2944974 DAPK3 siRNA or the inhibitor significantly *reduced* PDGF-BB induced activation of p38 and [heat-shock protein 27 (HSP27)] as determined by Western blotting . Positive_regulation HSPB1 EPHB2 19675578 2183003 The small heat-shock protein [Hsp27] undergoes *dependent* phosphorylation and redistribution to the cytoskeleton in response to dual leucine zipper bearing kinase expression . Positive_regulation HSPB1 EPHB2 20149037 2179049 The interaction between Hsp27 and MAPK was increased , suggesting that phosphorylation of [Hsp27] might be *induced* by p38 and in placentas from patients with pre-eclampsia . Positive_regulation HSPB1 EPHB2 21530534 2435211 Pretreatment with SL327 , an inhibitor of ERK phosphorylation , decreased activation ( phosphorylation ) of both ERK and Hsp27 ( pERK1 : 4.5±3.6 % , P < 0.0001 ; pERK2 : 42.3±3.3 % , P < 0.0001 ; and pHsp27 : 97.6±1.5 % , P=0.008 ) , suggesting that activation *triggers* [Hsp27] phosphorylation . Positive_regulation HSPB1 TNF 11421614 830842 [Hsp 27] does not *induce* secretion of , IL-10 , or IL-12 , whereas LPS does signal IL-12 and TNF-alpha secretion . Positive_regulation HSPB1 TNF 12694807 1080891 Stimulation of neutrophils by *increased* the levels of [HSP27] in the presence , but not in the absence , of cycloheximide . Positive_regulation HSPB1 TNF 12694807 1080919 The accumulation of [HSP27] *induced* by plus cycloheximide was also suppressed by pretreatment with a specific protein kinase C ( PKC ) inhibitor . Positive_regulation HSPB1 TNF 12694807 1080920 p38 MAP kinase ( but not p44/p42 MAP kinase ) and PKC take part in *stimulated* [HSP27] induction in human neutrophils . Positive_regulation HSPB1 TNF 17069861 1654794 Parallel to the decrease of HSP27 , *increased* the level of [HSP27] in the incubation medium of the cells . Positive_regulation HSPB1 TNF 17069861 1654795 The decrease of [HSP27] *induced* by was suppressed by the pretreatment of PBMCs with the specific protein kinase C ( PKC ) inhibitor , GF109203X . Positive_regulation HSPB1 TNF 18486623 1927779 stimulation *induced* p38 MAPK dependent phosphorylation of MK2 and [HSP27] . Positive_regulation HSPB1 TNF 1872799 165176 When cells had been depleted of protein kinase C ( PKC ) by prolonged treatment with PMA , stimulation by IL1 , or bradykinin still *increased* [hsp 27] phosphorylation . Positive_regulation HSPB1 TNF 7673331 325940 *induces* changes in the phosphorylation , cellular localization , and oligomerization of human [hsp27] , a stress protein that confers cellular resistance to this cytokine . Positive_regulation HSPB1 TNF 7673331 325941 Here , we have analyzed the *mediated* changes in the phosphorylation , cellular localization , and structural organization of [hsp27] in HeLa cells . Positive_regulation HSPB1 TNF 7673331 325942 We report that the *mediated* [hsp27] phosphorylation is a long lasting phenomenon that correlates with the cytostatic effect of this cytokine . Positive_regulation HSPB1 TNF 7851416 294354 *Induction* of [HSP27] kinase activity by or H2O2 was completely inhibited by first treating the cells with the antioxidant N-acetyl-L-cysteine , suggesting that generation of reactive oxygen metabolites was the key triggering element of this induction . Positive_regulation HSPB1 TNF 7858064 287033 Treatment of cells with different kinase inhibitors ( staurosporine , H7 , H8 , HA-1004 , or chelerythrine chloride ) failed to inhibit *induced* [Hsp28] phosphorylation , suggesting that neither protein kinase C nor other common protein kinases were involved . Positive_regulation HSPB1 TNF 9332492 457639 Our data show that TPA and *stimulate* an immediate and massive phosphorylation of [HSP27] , whereas OH-TAM affect the phosphorylation status of the protein only after a 3 day delay . Positive_regulation HSPB1 TNF 9620170 510483 To independently investigate the role of Hsp25 phosphorylation , we blocked *induced* phosphorylation of [wt-Hsp25] using SB203580 , a specific inhibitor of the P38 MAP kinase . Positive_regulation HSPB1 TNFSF10 12460647 1021912 treatment does not *induce* [HSP27] , HSP70 , or HSP90 levels . Positive_regulation HSPB1 TNFSF10 24308965 2904869 Co-immunoprecipitation and confocal microscopy showed that HSP27 interacted with Src and scaffolding protein ß-arrestin2 in response of TRAIL stimulation and suppression of HSP27 phosphorylation apparently disrupted the *induced* interaction of HSP27 and Src or interaction of [HSP27] and ß-arrestin2 . Positive_regulation HSPB3 TNF 11889017 920115 *regulates* insulin-like growth factor-1 and insulin-like growth factor binding [protein-3] expression in vascular smooth muscle . Positive_regulation HSPB3 TNF 12388275 1031306 Specifically , we found decreased expression of TNF-alpha- and NF-kappaB induced antiapoptotic genes such as growth arrest and DNA damage-inducible ( GADD)45beta , Flice inhibitory protein (FLIP) , and *induced* [protein 3] ( A20 ) . Positive_regulation HSPB3 TNF 16365179 1512405 *induced* [protein 3] ( TNFAIP3 ) was identified as a new regulatory component of a putative cytoplasmic signaling cascade that mediates NF-kappaB activation in response to DNA damage caused by O6-alkylating agents . Positive_regulation HSPB3 TNF 17982455 1831305 This SNP maps to 6q23 , between the genes oligodendrocyte lineage transcription factor 3 ( OLIG3 ) and *induced* [protein 3] ( TNFAIP3 ) . Positive_regulation HSPB3 TNF 19165919 2007038 The TNFAIP3 ( alpha *induced* [protein 3] ) gene encodes a ubiquitin editing enzyme , A20 , that restricts NF-kappaB dependent signaling and prevents inflammation . Positive_regulation HSPB3 TNF 20585109 2290653 A20 or *induced* [protein 3] is a negative regulator of nuclear factor kappaB signaling . Positive_regulation HSPB3 TNF 21566665 2499905 The ubiquitin editing enzyme A20 ( *induced* [protein 3] ) serves as a critical brake on nuclear factor ?B ( NF-?B ) signaling . Positive_regulation HSPB3 TNF 21604024 2435926 *induced* [protein 3] or TNFAIP3 is involved in the negative feedback regulation of nuclear factor-?B ( NF-?B ) signaling in response to specific pro-inflammatory stimuli in different cell types . Positive_regulation HSPB3 TNF 22220267 2519377 Induction of protective genes in the recipient ( e.g. , heme oxygenase-1 (HO-1) , alpha *inducible* [protein3] ( tnfaip3 ) , biliverdin reductase ( BVR ) , Bcl2 , and others ) or administration of one or more of the products of HO-1 to the donor , the islets themselves , and/or the recipient offers an alternative or synergistic approach to improve islet graft survival and function . Positive_regulation HSPB3 TNF 23576877 2768503 The aim of this study was to examine the effect of a pulsed electromagnetic field on the production of inflammatory markers tumor necrosis factor (TNF) , transcription factor nuclear factor kappa B (NFkB) , and the expression of the A20 ( *induced* [protein 3] ) , in an inflamed-cell model . Positive_regulation HSPB3 TNF 23923005 2826422 We demonstrate a significant upregulation of endothelial nitric oxide synthase (eNOS) , *induced* [protein 3] ( TNFAIP3 ; Positive_regulation HSPB3 TNF 7561640 328322 Interleukin-1 and *increase* insulin-like growth factor binding [protein-3] ( IGFBP-3 ) production and IGFBP-3 protease activity in human articular chondrocytes . Positive_regulation HSPD1 CD14 12380680 997349 The use of neutralizing monoclonal antibodies showed that the cytokine inducing activity of [Cpn 60] .3 was *dependent* on its interaction with . Positive_regulation HSPD1 IL1B 9686605 521794 Homogeneous Escherichia coli [chaperonin 60] *induces* and IL-6 gene expression in human monocytes by a mechanism independent of protein conformation . Positive_regulation HSPD1 MMP28 9711934 527020 Chlamydial and human [HSP 60] *induce* TNF-alpha and production by macrophages . Positive_regulation HSPD1 MMP7 9711934 527035 Chlamydial and human [HSP 60] *induce* TNF-alpha and production by macrophages . Positive_regulation HSPD1 TNF 12686536 1099845 Recent studies have shown that commercially available recombinant human [heat shock protein 60] ( rhHSP60 ) could *induce* release from macrophages and monocytes in a manner similar to that of lipopolysaccharide (LPS) , e.g. via CD14 and Toll-like receptor 4 complex mediated signal transduction pathway . Positive_regulation HSPD1 TNF 19945465 2198994 *increased* [HSP60] expression , and this could be prevented by pretreatment with siRNA inhibiting p65 expression . Positive_regulation HSPD1 TNF 21192280 2414245 *resulted* in an increase in [HS protein (HSP) 60] , compared with untreated cells , those receiving HS/TNF , or TNF alone . Positive_regulation HSPD1 TNF 9711934 527015 Chlamydial and human [HSP 60] *induce* and MMP production by macrophages . Positive_regulation HSPE1 TNF 18096563 1869114 The aim of the present study was to investigate if [endometriotic peritoneal fluids (EPF)] could interfere with endometrial stromal cell ( ESC ) decidualization and if could be *involved* in the EPF effect . Positive_regulation HSPG2 ANGPT1 15920022 1420475 *had* no effect on [PLC] phosphorylation and IP3 production , thus its permeability decreasing effect could not be ascribed to inhibition of PLC activation . Positive_regulation HSPG2 ARSA 6711391 37372 PAF appears to be derived from a non-MC population of rat PLC , is not extractable from rat [PLC] in the *presence* of and is inhibited by MC extracts . Positive_regulation HSPG2 CAPN8 2297226 127583 We examined the question of whether was *involved* in the observed [PLC] activation by thrombin and trypsin . Positive_regulation HSPG2 EDN2 11330340 808139 Additionally , both RGS proteins reduced basal and *stimulated* [PLC] activity in these membranes by about 40 % . Positive_regulation HSPG2 EDN2 1900389 153975 The mechanisms of *stimulation* of [phospholipase C (PLC)] by , specifically the role of guanine nucleotide binding proteins ( GTP binding proteins ) in coupling the endothelin receptor to PLC , were investigated in rat mesangial cells . Positive_regulation HSPG2 EDN2 8477817 218633 The *activation* of [PLC] or PLD by in the three cell lines was mediated by the high affinity binding site ( nM range ) and was not significantly affected by either extracellular or intracellular Ca2+ . Positive_regulation HSPG2 EDN2 8631621 361293 To characterize the pharmacology of *induced* changes in [phospholipase C (PLC)] activity , intracellular calcium concentration ( [ Ca2+ ] i ) and cyclic adenosine monophosphate ( cAMP ) in cultured human ciliary muscle ( HCM ) cells . Positive_regulation HSPG2 EPHB2 19747075 2168247 These data suggest that the mitogenic effect of CMS2MS2 on fibroblasts is independent of its proteolytic activity , *requires* phosphorylation , and involves activation of [PLC] . Positive_regulation HSPG2 F2R 8857584 388315 [PLC] *activation* by the endogenously expressed and by the direct G protein activators , A1F-4 and guanosine 5'- [ gamma-thio ] triphosphate ( GTP gamma S ) , studied in intact and permeabilized cells , respectively , were also inhibited by toxin B treatment . Positive_regulation HSPG2 FAS 11007187 735360 We have previously reported that cross linking *resulted* in the activation of phosphatidylcholine-specific phospholipase C ( [PC-PLC] ) and the subsequent activation of protein kinase C ( PKC ) and phospholipase D (PLD) in A20 cells . Positive_regulation HSPG2 FAS 11007187 735392 In an attempt to correlate the existence of [PC-PLC] activity and *activation* of PLD by activation among various Fas expressing murine cell lines , we have investigated the effect of anti-Fas monoclonal antibody on PC-PLC and PLD activities in A20 , P388D1 and YAC-1 cell lines . Positive_regulation HSPG2 FAS 11795496 892386 There were no effects of genistein on *induced* activation of [PC-PLC] and protein kinase C . Positive_regulation HSPG2 FAS 12216112 986271 In contrast , cross linking *stimulated* the activity of PLD , [PC-PLC] , and SMase , translocation of PKC , and protein phosphorylation in Fas-resistant clone # 11 , similar to that of wild type cells . Positive_regulation HSPG2 GPR115 15788407 1410143 In this study , signaling downstream of mediated [phospholipase C (PLC)] *activation* has been investigated in a cell line coexpressing recombinant M ( 3 ) muscarinic acetylcholine and alpha ( 1B ) -adrenergic receptors . Positive_regulation HSPG2 GPR115 17077647 1650112 The inhibitor effect of dipyrone on IP accumulation may be due to direct inhibition of phospholipase C (PLC) or impairment of the *activation* of [PLC] by . Positive_regulation HSPG2 GPR115 23297405 2742126 Two of the three inhibitors also inhibited *stimulated* [PLC] activity in intact cell systems . Positive_regulation HSPG2 GPR115 9144337 429015 The extracellular Ca2+ ( Ca2+ ( o ) ) -sensing receptor ( CaR ) is a that *activates* [phospholipase C (PLC)] . Positive_regulation HSPG2 GPR132 15788407 1410132 In this study , signaling downstream of mediated [phospholipase C (PLC)] *activation* has been investigated in a cell line coexpressing recombinant M ( 3 ) muscarinic acetylcholine and alpha ( 1B ) -adrenergic receptors . Positive_regulation HSPG2 GPR132 17077647 1650101 The inhibitor effect of dipyrone on IP accumulation may be due to direct inhibition of phospholipase C (PLC) or impairment of the *activation* of [PLC] by . Positive_regulation HSPG2 GPR132 23297405 2742115 Two of the three inhibitors also inhibited *stimulated* [PLC] activity in intact cell systems . Positive_regulation HSPG2 GPR132 9144337 429004 The extracellular Ca2+ ( Ca2+ ( o ) ) -sensing receptor ( CaR ) is a that *activates* [phospholipase C (PLC)] . Positive_regulation HSPG2 GPR87 15788407 1410212 In this study , signaling downstream of mediated [phospholipase C (PLC)] *activation* has been investigated in a cell line coexpressing recombinant M ( 3 ) muscarinic acetylcholine and alpha ( 1B ) -adrenergic receptors . Positive_regulation HSPG2 GPR87 17077647 1650181 The inhibitor effect of dipyrone on IP accumulation may be due to direct inhibition of phospholipase C (PLC) or impairment of the *activation* of [PLC] by . Positive_regulation HSPG2 GPR87 23297405 2742195 Two of the three inhibitors also inhibited *stimulated* [PLC] activity in intact cell systems . Positive_regulation HSPG2 GPR87 9144337 429084 The extracellular Ca2+ ( Ca2+ ( o ) ) -sensing receptor ( CaR ) is a that *activates* [phospholipase C (PLC)] . Positive_regulation HSPG2 HRH1 10493819 646736 Sf9 cells expressing the LH receptor responded to hCG challenge with a concentration dependent accumulation of intracellular cAMP ( EC50 = 630 nM ) but not of inositol phosphates , whereas stimulation of the in Sf9 cells *led* to increased [phospholipase C (PLC)] activity . Positive_regulation HSPG2 IL1B 14612947 1163431 also *increased* tyrosine phosphorylation of [PLC-gamma] in Src kinase dependent manner . Positive_regulation HSPG2 IL1B 14612947 1163443 Moreover , *induced* association of [PLC-gamma] with SHPS-1 . Positive_regulation HSPG2 IL1B 8967514 366172 This study demonstrates that both and PDGF-BB could *induce* proliferation of ASM cells through the activation of tyrosine kinase and [PLC] , which in turn stimulate the formation of IP3 , a second messenger molecule . Positive_regulation HSPG2 MMP28 8705837 343761 [PLC] also *induced* expression in the cultured epithelial cells . Positive_regulation HSPG2 MMP28 9393778 467882 Gelatin and casein zymography of cell culture medium indicated that the broad-spectrum [PLC] of Bacillus cereus *induced* production in epithelial cells of human skin ( NHEK ) , human gingiva ( HGE ) , and porcine periodontal ligament ( PLE ) . Positive_regulation HSPG2 MMP7 8705837 343776 [PLC] also *induced* expression in the cultured epithelial cells . Positive_regulation HSPG2 MMP7 9393778 467897 Gelatin and casein zymography of cell culture medium indicated that the broad-spectrum [PLC] of Bacillus cereus *induced* production in epithelial cells of human skin ( NHEK ) , human gingiva ( HGE ) , and porcine periodontal ligament ( PLE ) . Positive_regulation HSPG2 NT5E 7595513 330489 BDNF and also induced an autophosphorylation of TrkB receptors and subsequently *resulted* in a phosphorylation and binding of [phospholipase C-gamma (PLC-gamma)] and SH2 containing sequence to the autophosphorylated TrkB receptors . Positive_regulation HSPG2 PDZK1 22528496 2613694 Interestingly , the expression of and PLC-ß3 , but not PLC-ß1 , markedly *potentiated* SST induced [PLC] activation . Positive_regulation HSPG2 SRGN 7741717 305895 In the present study we show that quisqualic acid ( QA ) , ( +/- ) -trans-1-aminocyclopentane-1,3-dicarboxylate ( trans-ACPD ) , glutamic acid and ibotenic acid inhibited p [ NH ] *stimulated* [PLC] by 44 , 41 , 36 and 25 % respectively . Positive_regulation HSPG2 SRGN 7741717 305896 Preincubation of bovine brain coated vesicles with pertussis toxin abolished the inhibitory effects of mGluR analogues and carbachol on p [ NH ] *stimulated* [PLC] activity . Positive_regulation HSPG2 TNF 10030839 591864 Increased mucin secretion and increased cGMP production in *response* to both appeared to be mediated by a phospholipase C that hydrolyzes phosphatidylcholine ( [PC-PLC] ) , and by protein kinase C ( PKC ) , since both responses were attenuated by either D609 ( 10 and 20 microg/ml ) , a specific PC-PLC inhibitor , or by each of three PKC inhibitors : Calphostin C ( 0.3 and 0.5 microM ) , bisindoylmaleimide ( GF 109203X , Go 6850 ; 20 nM ) , or Ro31-8220 ( 10 microM ) . Positive_regulation HSPG2 TNF 11483407 844328 These data suggest that , in A549 cells , *activates* [PC-PLC] to induce activation of PKCalpha and protein tyrosine kinase , resulting in the stimulation of IKK2 , and NF-kappaB in the ICAM-1 promoter , then initiation of ICAM-1 expression and neutrophil adhesion . Positive_regulation HSPG2 TNF 11854220 913516 Both LPS and [PLC] *induced* high levels of , interleukin 1 beta ( IL-1 beta-6 , gamma interferon ( IFN-gamma ) , MIP-1 alpha MIP-2 in the lungs but did not affect IL-18 levels . Positive_regulation HSPG2 TNF 16387297 1512740 100 mug/ml of carbocisteine was able to inhibit the *induced* expression of hST3GallV mRNA , FUT3 mRNA , C2/4GnT mRNA and sialyl-Lewis x epitopes as well as the TNF-alpha induced activity of [PI-PLC] in NCI-H292 cells . Positive_regulation HSPG2 TNF 7538427 301299 Incorporation of DHA into phospholipids selectively attenuates VCAM-1 induction by TNF-alpha and subsequent monocytic cell adhesion by inhibition of *stimulated* [PC-PLC] activation in HUVECs . Positive_regulation HSPG2 TNF 8134404 251726 One day after treatment with 125 micrograms TCDD/kg , *resulted* in 70 , 27 , 33 and 21 % decreases in DNA-SSB , mitochondrial and microsomal lipid peroxidation and [PLC] activation , respectively , relative to TCDD treated mice . Positive_regulation HSPG2 TNF 9414418 408183 HePC inhibited fMLP induced phosphatidylinositol-specific PLC activation in HL60 cells and *induced* activation of phosphatidylcholine-specific [PLC] in U937 cells . Positive_regulation HTC1 EPHB2 18442977 1921093 Inhibition of the beta-arrestin/Src/dynamin signaling blocked [5-HT(2A/C)] *activation* of and the counteractive effect of 5-HT(2A/C) on 5-HT(1A) regulation of NMDAR currents . Positive_regulation HTC2 EPHB2 18442977 1921098 Inhibition of the beta-arrestin/Src/dynamin signaling blocked [5-HT(2A/C)] *activation* of and the counteractive effect of 5-HT(2A/C) on 5-HT(1A) regulation of NMDAR currents . Positive_regulation HTN1 EDN2 9648078 515121 This study was designed to test the hypothesis that hypoxia induced [HTN] may be *mediated* by increased and/or decreased NO production . Positive_regulation HTN1 GPR115 19652025 2150266 Activation of cells by [histatin] *requires* a that activates the ERK1/2 pathway . Positive_regulation HTN1 GPR132 19652025 2150255 Activation of cells by [histatin] *requires* a that activates the ERK1/2 pathway . Positive_regulation HTN1 GPR87 19652025 2150335 Activation of cells by [histatin] *requires* a that activates the ERK1/2 pathway . Positive_regulation HTN3 EDN2 9648078 515124 This study was designed to test the hypothesis that hypoxia induced [HTN] may be *mediated* by increased and/or decreased NO production . Positive_regulation HTN3 GPR115 19652025 2150359 Activation of cells by [histatin] *requires* a that activates the ERK1/2 pathway . Positive_regulation HTN3 GPR132 19652025 2150348 Activation of cells by [histatin] *requires* a that activates the ERK1/2 pathway . Positive_regulation HTN3 GPR87 19652025 2150428 Activation of cells by [histatin] *requires* a that activates the ERK1/2 pathway . Positive_regulation HTN3 TNF 15864435 1401348 *induced* expression of [hST3GalIV] , FUT3 , C2/4GnT and MUC5AC mRNAs in NCI-H292 cells . Positive_regulation HTR1A EPHB2 10727402 677860 Five criteria were shown to support a key role for ROS in the *activation* of by the [5-HT(1A)] receptor . Positive_regulation HTR2A ARSA 9088041 421691 significantly increased brain serotonin ( 5-HT ) content and *reduced* the number of [5-HT2] receptors in cortical brain membranes 30 min after drug administration . Positive_regulation HTR2A EPHB2 10751227 681501 These studies demonstrate a role for the [5-HT(2A)] receptor in rapid , potent , and efficacious *activation* of in rat renal mesangial cells . Positive_regulation HTR2A TNF 21248590 2380035 *induced* [5-HT2A] receptor expressions in the DRG , while 5-HT induced TNF and TNF receptor 1 expressions . Positive_regulation HTR2C ADRB2 10702266 672523 G ( s ) CT , targeting the receptor-G ( s ) protein , disrupted *mediated* activation of cAMP but not [5-HT(2C)] receptor mediated phosphatidylinositide hydrolysis . Positive_regulation HTR3A RIC3 20522555 2301415 Furthermore , immunocytochemical studies on transfected mammalian cells revealed co-localization in the endoplasmic reticulum and direct interaction of RIC-3 with 5-HT3A , -C , -D , and -E. Functional and pharmacological characterization was performed using HEK293 cells expressing [5-HT3A] or 5-HT3A + 5-HT3B ( or -C , -D , or -E ) in the *presence* or absence of . Positive_regulation HTR3B RIC3 20522555 2301416 Furthermore , immunocytochemical studies on transfected mammalian cells revealed co-localization in the endoplasmic reticulum and direct interaction of RIC-3 with 5-HT3A , -C , -D , and -E. Functional and pharmacological characterization was performed using HEK293 cells expressing 5-HT3A or 5-HT3A + [5-HT3B] ( or -C , -D , or -E ) in the *presence* or absence of . Positive_regulation HTR4 TNF 1911345 167459 However , the possible *role* of in [HTR] has not been investigated . Positive_regulation HTR6 TNF 1911345 167460 However , the possible *role* of in [HTR] has not been investigated . Positive_regulation HTR7 TNF 1911345 167461 However , the possible *role* of in [HTR] has not been investigated . Positive_regulation HTRA1 TLR7 23982886 2855945 LPS and tenascin-C , but not the other ligands tested , strongly *induced* [HTRA-1] expression . Positive_regulation HTT CAPN8 12832525 1105755 In contrast , activation of calpain was specifically detected in the striatum in both models and this was associated with a *dependent* cleavage of [huntingtin] . Positive_regulation HTT TGM2 12528814 1048659 Transient transfection of N-terminally truncated huntingtin with an expanded glutamine domain ( htt-N63-148Q-myc ) with and without and into HEK 293T cells *resulted* in an increase in cross linked [huntingtin] in the insoluble formic acid treated pellet in comparison to transfection of N-terminally truncated huntingtin with normal length glutamine domain ( htt-N63-18Q-myc ) . Positive_regulation HUWE1 TNF 20624960 2297180 The interaction between [Mule] and Miz1 was *promoted* by independently of the pox virus and zinc finger domain of Miz1 . Positive_regulation HYAL1 IL1B 18390475 1944176 We found that [Hyal-like] activity is present in the apical and basolateral secretions from HBE cells where Hyals 1 , 2 , and 3 are expressed , and that *acts* synergistically with TNF-alpha to increase gene expression and activity . Positive_regulation HYAL2 IL1B 18390475 1944177 We found that [Hyal-like] activity is present in the apical and basolateral secretions from HBE cells where Hyals 1 , 2 , and 3 are expressed , and that *acts* synergistically with TNF-alpha to increase gene expression and activity . Positive_regulation HYAL3 IL1B 18390475 1944178 We found that [Hyal-like] activity is present in the apical and basolateral secretions from HBE cells where Hyals 1 , 2 , and 3 are expressed , and that *acts* synergistically with TNF-alpha to increase gene expression and activity . Positive_regulation HYAL4 IL1B 18390475 1944179 We found that [Hyal-like] activity is present in the apical and basolateral secretions from HBE cells where Hyals 1 , 2 , and 3 are expressed , and that *acts* synergistically with TNF-alpha to increase gene expression and activity . Positive_regulation HYOU1 FOXO1 22564731 2608771 Forkhead box O1 (FOXO1) was involved in the regulation of ORP150 expression because suppression of *inhibited* the induction of [ORP150] by SIRT1 . Positive_regulation IAPP FAS 19843871 2299412 also significantly *induced* human [amylin] promoter activation . Positive_regulation IAPP FAS 19843871 2299415 These data demonstrate that differently regulate amylin and insulin expression and *induce* both [amylin] and insulin release . Positive_regulation IAPP TNF 21116608 2383670 acutely *upregulates* [amylin] expression in murine pancreatic beta cells . Positive_regulation IAPP TNF 21116608 2383672 acutely *induced* [amylin] expression at the transcriptional level and increased proamylin and the intermediate form of amylin in MIN6 cells and islets . Positive_regulation IAPP UNC5B 15729359 1396329 In the absence of netrin-1 , UNC5H2 reduces DAP-kinase autophosphorylation on Ser308 and increases the catalytic activity of the kinase while netrin-1 blocks *dependent* [DAP-kinase] activation . Positive_regulation IARS ALDH2 19344727 2094371 significantly attenuated alcohol induced decrease in the insulin stimulated tyrosine phosphorylation and *increase* in serine phosphorylation of [IRS] . Positive_regulation IARS FOXO1 20501674 2294827 Increased activity *augments* the expression of insulin receptor (IR) and [IR substrate (IRS)2] , which in turn inhibits FoxO1 activity in response to reduced insulin action . Positive_regulation IBD2 ARSA 21765868 2456671 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Positive_regulation IBD2 IL1B 19740775 2163244 IL23 and plus IL6 *had* no effect on [IBD] LPMC production of IL17 ; Positive_regulation IBD2 ITGAL 14518246 480052 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Positive_regulation IBD2 ITGB2 7648720 318971 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Positive_regulation IBD2 JAG1 15294991 1279089 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Positive_regulation IBD2 PECAM1 17510197 1772782 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Positive_regulation IBD2 TLR7 18031248 1828174 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Positive_regulation IBD2 TNF 12486099 1025210 Genetic dissection of the cellular pathways and signaling mechanisms in modeled *induced* Crohn's-like [inflammatory bowel disease] . Positive_regulation IBD2 TNF 15366373 1294673 However , these mice display complete susceptibility to *induced* [inflammatory bowel disease] . Positive_regulation IBD2 TNF 16093357 1481986 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Positive_regulation IBD2 TNF 18187519 1876051 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Positive_regulation IBD2 TNF 20943999 2343592 Because the inflammatory cytokine *contributes* to [inflammatory bowel disease] in part by compromising intestinal epithelial barrier integrity , hydroxylase inhibition may have beneficial effects in TNF-a induced intestinal epithelial damage . Positive_regulation IBD2 TNF 23898046 2844670 Its ablation gives rise to an anti-inflammatory phenotype characterized by resistance to LPS induced endotoxin shock , DSS induced colitis , and *induced* [IBD] . Positive_regulation IBD2 TNF 8734357 374172 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Positive_regulation IBD2 TNFSF10 19954896 2199268 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Positive_regulation IBD3 ARSA 21765868 2456667 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Positive_regulation IBD3 IL1B 19740775 2163236 IL23 and plus IL6 *had* no effect on [IBD] LPMC production of IL17 ; Positive_regulation IBD3 ITGAL 14518246 480048 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Positive_regulation IBD3 ITGB2 7648720 318963 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Positive_regulation IBD3 JAG1 15294991 1279085 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Positive_regulation IBD3 PECAM1 17510197 1772778 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Positive_regulation IBD3 TLR7 18031248 1828134 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Positive_regulation IBD3 TNF 12486099 1025206 Genetic dissection of the cellular pathways and signaling mechanisms in modeled *induced* Crohn's-like [inflammatory bowel disease] . Positive_regulation IBD3 TNF 15366373 1294669 However , these mice display complete susceptibility to *induced* [inflammatory bowel disease] . Positive_regulation IBD3 TNF 16093357 1481982 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Positive_regulation IBD3 TNF 18187519 1876047 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Positive_regulation IBD3 TNF 20943999 2343588 Because the inflammatory cytokine *contributes* to [inflammatory bowel disease] in part by compromising intestinal epithelial barrier integrity , hydroxylase inhibition may have beneficial effects in TNF-a induced intestinal epithelial damage . Positive_regulation IBD3 TNF 23898046 2844666 Its ablation gives rise to an anti-inflammatory phenotype characterized by resistance to LPS induced endotoxin shock , DSS induced colitis , and *induced* [IBD] . Positive_regulation IBD3 TNF 8734357 374168 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Positive_regulation IBD3 TNFSF10 19954896 2199264 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Positive_regulation IBD4 ARSA 21765868 2456672 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Positive_regulation IBD4 IL1B 19740775 2163246 IL23 and plus IL6 *had* no effect on [IBD] LPMC production of IL17 ; Positive_regulation IBD4 ITGAL 14518246 480053 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Positive_regulation IBD4 ITGB2 7648720 318973 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Positive_regulation IBD4 JAG1 15294991 1279090 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Positive_regulation IBD4 PECAM1 17510197 1772783 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Positive_regulation IBD4 TLR7 18031248 1828184 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Positive_regulation IBD4 TNF 12486099 1025211 Genetic dissection of the cellular pathways and signaling mechanisms in modeled *induced* Crohn's-like [inflammatory bowel disease] . Positive_regulation IBD4 TNF 15366373 1294674 However , these mice display complete susceptibility to *induced* [inflammatory bowel disease] . Positive_regulation IBD4 TNF 16093357 1481987 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Positive_regulation IBD4 TNF 18187519 1876052 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Positive_regulation IBD4 TNF 20943999 2343593 Because the inflammatory cytokine *contributes* to [inflammatory bowel disease] in part by compromising intestinal epithelial barrier integrity , hydroxylase inhibition may have beneficial effects in TNF-a induced intestinal epithelial damage . Positive_regulation IBD4 TNF 23898046 2844671 Its ablation gives rise to an anti-inflammatory phenotype characterized by resistance to LPS induced endotoxin shock , DSS induced colitis , and *induced* [IBD] . Positive_regulation IBD4 TNF 8734357 374173 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Positive_regulation IBD4 TNFSF10 19954896 2199269 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Positive_regulation IBD5 ARSA 21765868 2456673 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Positive_regulation IBD5 IL1B 19740775 2163248 IL23 and plus IL6 *had* no effect on [IBD] LPMC production of IL17 ; Positive_regulation IBD5 ITGAL 14518246 480054 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Positive_regulation IBD5 ITGB2 7648720 318975 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Positive_regulation IBD5 JAG1 15294991 1279091 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Positive_regulation IBD5 PECAM1 17510197 1772784 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Positive_regulation IBD5 TLR7 18031248 1828194 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Positive_regulation IBD5 TNF 12486099 1025212 Genetic dissection of the cellular pathways and signaling mechanisms in modeled *induced* Crohn's-like [inflammatory bowel disease] . Positive_regulation IBD5 TNF 15366373 1294675 However , these mice display complete susceptibility to *induced* [inflammatory bowel disease] . Positive_regulation IBD5 TNF 16093357 1481988 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Positive_regulation IBD5 TNF 18187519 1876053 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Positive_regulation IBD5 TNF 20943999 2343594 Because the inflammatory cytokine *contributes* to [inflammatory bowel disease] in part by compromising intestinal epithelial barrier integrity , hydroxylase inhibition may have beneficial effects in TNF-a induced intestinal epithelial damage . Positive_regulation IBD5 TNF 23898046 2844672 Its ablation gives rise to an anti-inflammatory phenotype characterized by resistance to LPS induced endotoxin shock , DSS induced colitis , and *induced* [IBD] . Positive_regulation IBD5 TNF 8734357 374174 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Positive_regulation IBD5 TNFSF10 19954896 2199270 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Positive_regulation IBD6 ARSA 21765868 2456674 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Positive_regulation IBD6 IL1B 19740775 2163250 IL23 and plus IL6 *had* no effect on [IBD] LPMC production of IL17 ; Positive_regulation IBD6 ITGAL 14518246 480055 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Positive_regulation IBD6 ITGB2 7648720 318977 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Positive_regulation IBD6 JAG1 15294991 1279092 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Positive_regulation IBD6 PECAM1 17510197 1772785 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Positive_regulation IBD6 TLR7 18031248 1828204 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Positive_regulation IBD6 TNF 12486099 1025213 Genetic dissection of the cellular pathways and signaling mechanisms in modeled *induced* Crohn's-like [inflammatory bowel disease] . Positive_regulation IBD6 TNF 15366373 1294676 However , these mice display complete susceptibility to *induced* [inflammatory bowel disease] . Positive_regulation IBD6 TNF 16093357 1481989 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Positive_regulation IBD6 TNF 18187519 1876054 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Positive_regulation IBD6 TNF 20943999 2343595 Because the inflammatory cytokine *contributes* to [inflammatory bowel disease] in part by compromising intestinal epithelial barrier integrity , hydroxylase inhibition may have beneficial effects in TNF-a induced intestinal epithelial damage . Positive_regulation IBD6 TNF 23898046 2844673 Its ablation gives rise to an anti-inflammatory phenotype characterized by resistance to LPS induced endotoxin shock , DSS induced colitis , and *induced* [IBD] . Positive_regulation IBD6 TNF 8734357 374175 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Positive_regulation IBD6 TNFSF10 19954896 2199271 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Positive_regulation IBD7 ARSA 21765868 2456668 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Positive_regulation IBD7 IL1B 19740775 2163238 IL23 and plus IL6 *had* no effect on [IBD] LPMC production of IL17 ; Positive_regulation IBD7 ITGAL 14518246 480049 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Positive_regulation IBD7 ITGB2 7648720 318965 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Positive_regulation IBD7 JAG1 15294991 1279086 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Positive_regulation IBD7 PECAM1 17510197 1772779 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Positive_regulation IBD7 TLR7 18031248 1828144 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Positive_regulation IBD7 TNF 12486099 1025207 Genetic dissection of the cellular pathways and signaling mechanisms in modeled *induced* Crohn's-like [inflammatory bowel disease] . Positive_regulation IBD7 TNF 15366373 1294670 However , these mice display complete susceptibility to *induced* [inflammatory bowel disease] . Positive_regulation IBD7 TNF 16093357 1481983 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Positive_regulation IBD7 TNF 18187519 1876048 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Positive_regulation IBD7 TNF 20943999 2343589 Because the inflammatory cytokine *contributes* to [inflammatory bowel disease] in part by compromising intestinal epithelial barrier integrity , hydroxylase inhibition may have beneficial effects in TNF-a induced intestinal epithelial damage . Positive_regulation IBD7 TNF 23898046 2844667 Its ablation gives rise to an anti-inflammatory phenotype characterized by resistance to LPS induced endotoxin shock , DSS induced colitis , and *induced* [IBD] . Positive_regulation IBD7 TNF 8734357 374169 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Positive_regulation IBD7 TNFSF10 19954896 2199265 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Positive_regulation IBD8 ARSA 21765868 2456669 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Positive_regulation IBD8 IL1B 19740775 2163240 IL23 and plus IL6 *had* no effect on [IBD] LPMC production of IL17 ; Positive_regulation IBD8 ITGAL 14518246 480050 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Positive_regulation IBD8 ITGB2 7648720 318967 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Positive_regulation IBD8 JAG1 15294991 1279087 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Positive_regulation IBD8 PECAM1 17510197 1772780 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Positive_regulation IBD8 TLR7 18031248 1828154 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Positive_regulation IBD8 TNF 12486099 1025208 Genetic dissection of the cellular pathways and signaling mechanisms in modeled *induced* Crohn's-like [inflammatory bowel disease] . Positive_regulation IBD8 TNF 15366373 1294671 However , these mice display complete susceptibility to *induced* [inflammatory bowel disease] . Positive_regulation IBD8 TNF 16093357 1481984 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Positive_regulation IBD8 TNF 18187519 1876049 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Positive_regulation IBD8 TNF 20943999 2343590 Because the inflammatory cytokine *contributes* to [inflammatory bowel disease] in part by compromising intestinal epithelial barrier integrity , hydroxylase inhibition may have beneficial effects in TNF-a induced intestinal epithelial damage . Positive_regulation IBD8 TNF 23898046 2844668 Its ablation gives rise to an anti-inflammatory phenotype characterized by resistance to LPS induced endotoxin shock , DSS induced colitis , and *induced* [IBD] . Positive_regulation IBD8 TNF 8734357 374170 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Positive_regulation IBD8 TNFSF10 19954896 2199266 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Positive_regulation IBD9 ARSA 21765868 2456670 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Positive_regulation IBD9 IL1B 19740775 2163242 IL23 and plus IL6 *had* no effect on [IBD] LPMC production of IL17 ; Positive_regulation IBD9 ITGAL 14518246 480051 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Positive_regulation IBD9 ITGB2 7648720 318969 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Positive_regulation IBD9 JAG1 15294991 1279088 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Positive_regulation IBD9 PECAM1 17510197 1772781 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Positive_regulation IBD9 TLR7 18031248 1828164 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Positive_regulation IBD9 TNF 12486099 1025209 Genetic dissection of the cellular pathways and signaling mechanisms in modeled *induced* Crohn's-like [inflammatory bowel disease] . Positive_regulation IBD9 TNF 15366373 1294672 However , these mice display complete susceptibility to *induced* [inflammatory bowel disease] . Positive_regulation IBD9 TNF 16093357 1481985 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Positive_regulation IBD9 TNF 18187519 1876050 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Positive_regulation IBD9 TNF 20943999 2343591 Because the inflammatory cytokine *contributes* to [inflammatory bowel disease] in part by compromising intestinal epithelial barrier integrity , hydroxylase inhibition may have beneficial effects in TNF-a induced intestinal epithelial damage . Positive_regulation IBD9 TNF 23898046 2844669 Its ablation gives rise to an anti-inflammatory phenotype characterized by resistance to LPS induced endotoxin shock , DSS induced colitis , and *induced* [IBD] . Positive_regulation IBD9 TNF 8734357 374171 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Positive_regulation IBD9 TNFSF10 19954896 2199267 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Positive_regulation ICAM1 ALOX5 15132836 1245621 Inhibitors of <5-lipoxygenase> *inhibit* expression of [intercellular adhesion molecule-1] in human melanoma cells . Positive_regulation ICAM1 CAPN8 22140070 2548579 Inhibition of activity by means of siRNA silencing or pharmacological inhibition also *reduced* endothelial nitric oxide (NO) synthase ( NOS-3 ) -mediated NO production and subsequent [ICAM-1] phosphorylation following high tidal volume ventilation . Positive_regulation ICAM1 CD14 18363879 1925401 [ICAM-1] upregulation on human monocytes by the LOS *required* surface , TLR4 , NF-kappaB p65 and c-Jun N-terminal kinase (JNK) activity . Positive_regulation ICAM1 CD14 8945531 400307 Soluble mediates lipopolysaccharide *induced* [intercellular adhesion molecule 1] expression in cultured human gingival fibroblasts . Positive_regulation ICAM1 CD14 8945531 400312 Since HGF did not express endogenous CD14 , we investigated the *role* of human serum derived soluble ( sCD14 ) in [ICAM-1] induction on HGF by LPS . Positive_regulation ICAM1 CD14 8945531 400314 These results show that induction of [ICAM-1] in HGF by LPS does not *involve* binding to cell surface but is mediated by serum derived sCD14 . Positive_regulation ICAM1 EPHB2 12354421 993584 Specific kinase inhibitor PD98059 *inhibited* IgM-AECA induced ERK1/2 activities and [ICAM-1] expression on HDMEC at a concentration of 60 microM . Positive_regulation ICAM1 EPHB2 17276892 1691899 The inhibitory effect of paeonol on [ICAM-1] production might be *mediated* by inhibiting p38 , and NF-kappaB signaling pathways , which are involved in TNF-alpha induced ICAM-1 production . Positive_regulation ICAM1 EPHB2 17292586 1725856 TNFR1 induced NF-kappaB , but not , p38MAPK or JNK activation , *mediates* TNF induced [ICAM-1] and VCAM-1 expression on endothelial cells . Positive_regulation ICAM1 EPHB2 17467021 1743418 Inhibition of , JNK , or NF-kappaB *attenuates* TNF-alpha induced [ICAM-1] promoter activation and monocyte-endothelial monolayer binding . Positive_regulation ICAM1 EPHB2 18656701 1942692 Selective inhibitors of p38 MAPK ( SB203580 ) , JNK ( SP600125 ) and ( PD98059 ) could *suppress* TNF-alpha induced CCL2 and [ICAM-1] expression , while only p38 MAPK and ERK inhibitors could suppress TNF-alpha induced VCAM-1 expression . Positive_regulation ICAM1 EPHB2 20432452 2268154 These results suggest that in human RASFs , activation of , JNK , AP-1 , and NF-kappaB are *essential* for IL-1beta induced [ICAM-1] expression and leukocyte adhesion . Positive_regulation ICAM1 EPHB2 22842465 2646582 Omentin , NF-kB inhibitor ( BAY11-7082 ) and inhibitor ( PD98059 ) *reduced* the up-regulation of [ICAM-1] and VCAM-1 induced by TNF-a . Positive_regulation ICAM1 EPHB2 22972429 2706281 HDL isolated from ELKO , ELTg , and WT mice inhibited expression of [intercellular adhesion molecule-1] , angiotensin II-induced *activation* of , and growth of cultured vascular smooth muscle cells , whereas EL expression itself did not affect cell migration or growth . Positive_regulation ICAM1 EPHB2 23098564 2695168 By using specific inhibitors and short hairpin RNA ( shRNA ) , we demonstrated that the activation of , JNK and p38 pathways is *critical* for SDF-1 induced [ICAM-1] expression and cell adhesion . Positive_regulation ICAM1 F2R 12215488 986052 These results support a model in which ligation of *induces* NF-kappaB activation and [ICAM-1] transcription by the engagement of parallel Galphaq/PKC-delta and Gbetagamma/PI3-kinase pathways that converge at Akt . Positive_regulation ICAM1 FAS 11490158 845649 Exposure of HUVEC to recombinant human TNF-alpha increased the expression of both ICAM-1 and , but a much lower concentration was *required* for an effect upon [ICAM-1] . Positive_regulation ICAM1 FAS 14615040 1163686 We demonstrate that ligation *induces* [ICAM-1] expression at the mRNA and protein levels in human astroglioma cells . Positive_regulation ICAM1 FAS 14615040 1163687 Studies using Boc-D-Fmk , a pharmacological inhibitor , show that caspase activation is required for mediated [ICAM-1] *induction* . Positive_regulation ICAM1 FAS 14615040 1163701 These findings suggest that ligation on human glioma cells *leads* to the induction of [ICAM-1] expression , which involves caspase cascade signaling pathways . Positive_regulation ICAM1 FAS 18525261 1922990 We assessed changes in plasma levels of von Willebrand factor , soluble vascular cell adhesion molecule-1 and [intercellular adhesion molecule-1] by enzyme linked immunosorbent assay , as well as T-cell *activation* ( CD8+/CD38+ , CD8+/HLA-DR+ and ) by flow cytometry , in 36 chronically HIV-1 infected patients participating in a randomized study . Positive_regulation ICAM1 GPR115 24259506 2892798 Investigating the interactions of neutrophils from wild-type , CD11a ( -/- ) , CD11b ( -/- ) , and CD18 ( null ) mice with wild-type , junctional adhesion molecule-A ( -/- ) , ICAM-1 ( null ) , ICAM-2 ( -/- ) , or ICAM-1 ( null ) /ICAM-2 ( -/- ) primary mouse brain microvascular endothelial cells , we demonstrate that neutrophil arrest , polarization , and crawling required *dependent* activation of ß2 integrins and binding to endothelial [ICAM-1] . Positive_regulation ICAM1 GPR132 24259506 2892787 Investigating the interactions of neutrophils from wild-type , CD11a ( -/- ) , CD11b ( -/- ) , and CD18 ( null ) mice with wild-type , junctional adhesion molecule-A ( -/- ) , ICAM-1 ( null ) , ICAM-2 ( -/- ) , or ICAM-1 ( null ) /ICAM-2 ( -/- ) primary mouse brain microvascular endothelial cells , we demonstrate that neutrophil arrest , polarization , and crawling required *dependent* activation of ß2 integrins and binding to endothelial [ICAM-1] . Positive_regulation ICAM1 GPR87 24259506 2892867 Investigating the interactions of neutrophils from wild-type , CD11a ( -/- ) , CD11b ( -/- ) , and CD18 ( null ) mice with wild-type , junctional adhesion molecule-A ( -/- ) , ICAM-1 ( null ) , ICAM-2 ( -/- ) , or ICAM-1 ( null ) /ICAM-2 ( -/- ) primary mouse brain microvascular endothelial cells , we demonstrate that neutrophil arrest , polarization , and crawling required *dependent* activation of ß2 integrins and binding to endothelial [ICAM-1] . Positive_regulation ICAM1 HES2 16247329 1471620 After stimulation with IL-1 ( 10 U/mL ) , *had* no effect on the expression of P-selectin , E-selectin , [ICAM-1] , or VCAM-1 . Positive_regulation ICAM1 IL1B 10074208 594745 *Induction* of interleukin-6 (IL-6) and [ICAM-1] by was not suppressed by infection with EZ , suggesting that the inhibition of IFN signaling is specific . Positive_regulation ICAM1 IL1B 10207838 606918 potently induced ICAM-1 expression in HGF and indomethacin , a cyclooxygenase inhibitor , *enhanced* [ICAM-1] expression in the cells . Positive_regulation ICAM1 IL1B 10382751 624353 PDTC treated mice survived despite high and IL-6 levels , *induction* of VCAM-1 and [ICAM-1] expression or leukocyte infiltration in tissues known to be associated with LPS induced shock , indicating that PDTC does not act by modifying these responses . Positive_regulation ICAM1 IL1B 10430178 633564 TNF-alpha and *stimulated* cell surface [ICAM-1] expression , but not VCAM-1 expression , in human aortic smooth muscle cells ( HASMCs ) . Positive_regulation ICAM1 IL1B 10532635 562348 To investigate the *role* of in regulation of tumor necrosis factor-alpha (TNF-alpha) and [intercellular adhesion molecule-1] ( ICAM-1 ) during focal cerebral ischemia , the authors studied mutant mice deficient in the IL-1 converting enzyme (ICE) gene ( ICE knockout [ KO ] mice ) . Positive_regulation ICAM1 IL1B 10559516 566639 Enrichment of HAEC with the same doses of vitamin E suppressed *stimulated* expression of [intercellular adhesion molecule-1] ( ICAM-1 ) , vascular cell adhesion molecule-1 ( VCAM-1 ) , and endothelial leukocyte adhesion molecule-1 ( E-selectin ) . Positive_regulation ICAM1 IL1B 10573217 568780 ( optimal concentration ( OC ) 1 U x mL(-1) ) and TNFalpha ( OC 100 U x mL(-1) ) both *increased* [ICAM-1] and VCAM-1 expression . Positive_regulation ICAM1 IL1B 10741905 680022 Both IL-1alpha and *induced* [ICAM-1] expression and IL-8 and MCP-1 production at lower doses than TNF alpha or TNF beta . Positive_regulation ICAM1 IL1B 10779013 687122 When measured by enzyme linked immunosorbent assay ( ELISA ) , [ICAM-1] was constitutively expressed and was *up-regulated* twofold by , with no effect of interferon-gamma . Positive_regulation ICAM1 IL1B 10807407 692191 The expression of CD11b and CD18 on neutrophils and neutrophil dependent adhesion to endothelial cells elicited by HPE were inhibited by lansoprazole and omeprazole at clinical relevant doses , and the expression of [ICAM-1] and VCAM-1 on endothelial cells and endothelial dependent neutrophil adherence *induced* by were also inhibited by lansoprazole and omeprazole at similar doses . Positive_regulation ICAM1 IL1B 10807794 692369 The presence of cytokine in the perfusion system *enhanced* the production of [ICAM-1] and VCAM-1 mRNA , cell surface expression , and the concentrations of circulating forms . Positive_regulation ICAM1 IL1B 10868446 706521 and 3 ) the upregulation of SOD mRNA , with subsequent increase in the SOD production and local release of and TNF-alpha , may *activate* [ICAM-1] expression and neutrophil infiltration , which appear to play an important role in the progression of I/R induced acute gastric erosions into chronic ulcers . Positive_regulation ICAM1 IL1B 10886302 709679 Upon *stimulation* with the expression of E-selectin , VCAM-1 and [ICAM-1] ( CD54 ) was upregulated . Positive_regulation ICAM1 IL1B 10900176 712705 DPI also inhibited TNF and LPS induced VCAM-1 and ICAM-1 cell surface expression and TNF- alpha , LPS , or *induced* VCAM-1 and [ICAM-1] mRNA accumulation . Positive_regulation ICAM1 IL1B 10908988 713805 The findings indicate that stimulation of [ICAM-1] by endotoxin is *mediated* , at least in part , by TNF-alpha and . Positive_regulation ICAM1 IL1B 11311334 804954 Membrane [ICAM-1] and mRNA expression are absent under basal conditions , but can be *induced* by IFN-gamma , , IL-4 , LPS and IL-6 with different efficiencies and time-courses . Positive_regulation ICAM1 IL1B 11403206 824946 At 4 h [ICAM-1] and E-selectin , but not VACM-1 , were *stimulated* by both and TNF-alpha . Positive_regulation ICAM1 IL1B 11403206 824953 [ICAM-1] , VCAM-1 , and E-selectin expression were all *stimulated* by both and TNF-alpha in the 24 h assays . Positive_regulation ICAM1 IL1B 11717194 881919 Moreover , the adherence of IL-1beta stimulated HGF to activated lymphocytes was also inhibited by adenosine , which is in part explained by the fact that adenosine down-regulated the *induced* expression of [ICAM-1] on HGF . Positive_regulation ICAM1 IL1B 11788788 892042 NO at subtoxic concentrations decreases *induced* endothelial [ICAM-1] mRNA expression . Positive_regulation ICAM1 IL1B 11788788 892043 This inhibition occurs at the transcriptional level , as NO affects *induced* [ICAM-1] promoter activity in transiently transfected cells . Positive_regulation ICAM1 IL1B 12121710 965085 Pretreatment with estrogen or progesterone alone decreased *stimulated* VCAM-1 and [ICAM-1] expression , but not to statistically significant levels . Positive_regulation ICAM1 IL1B 12124212 965698 Because IL-18 is a proinflammatory cytokine known to mediate the production of TNF-alpha and and to *induce* the expression of [intercellular adhesion molecule-1] ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) , we hypothesized that neutralization of IL-18 would attenuate lipopolysaccharide (LPS) induced cardiac dysfunction . Positive_regulation ICAM1 IL1B 12161274 971920 The microglial expression of [ICAM-1] is a further indicator of the presence of inflammatory reactions in aged transgenic Tg2576 mouse brain , and may be a *result* of plaque mediated astrocytic upregulation . Positive_regulation ICAM1 IL1B 12181421 977590 We studied the effect of an inosine-5'-monophosphate dehydrogenase ( IMPDH ) inhibitor , mycophenolic acid ( MPA ) , on constitutive and *induced* expression of [ICAM-1] in human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation ICAM1 IL1B 12181421 977593 Unexpectedly , pretreatment with MPA enhanced the constitutive expression and potentiated the *induction* of [ICAM-1] by , as detected by flow cytometry . Positive_regulation ICAM1 IL1B 12191851 980659 In all preparations of HUVECs used in this study , RT-PCR confirmed mRNA expression of both isoforms of PR , PR-A and PR-B , as well as AR. Addition of progesterone ( 10 ( -10 ) -10 ( -7 ) M ) or dienogest ( DNG ) ( 10 ( -10 ) -10 ( -8 ) M ) did not affect *stimulated* [ICAM-1] or VCAM-1 expression . Positive_regulation ICAM1 IL1B 12210732 984092 On the other hand , , a Th1 proinflammatory cytokine , dramatically increases nitrite and nitrate levels , as well as inducible nitric oxide synthase (iNOS) transcripts and also *upregulates* islet [ICAM-1] expression as well as circulating ICAM-1 levels . Positive_regulation ICAM1 IL1B 12498315 1026319 *induced* expression of [intercellular adhesion molecule-1] and monocyte chemoattractant protein-1 , both of which were abolished in the presence of pyrrolidine dithiocarbamate , a specific inhibitor of nuclear factor-kappaB activation . Positive_regulation ICAM1 IL1B 12507783 1038446 TGF-beta 1 and IL-10 modulate *induced* membrane and soluble [ICAM-1] in human myoblasts . Positive_regulation ICAM1 IL1B 12507783 1038447 In this paper we found that IL-10 and transforming growth factor (TGF)-beta 1 are able to prevent *induced* membrane and soluble [ICAM-1] protein expression on human myoblasts , with different time courses . Positive_regulation ICAM1 IL1B 12562387 1053791 By in vitro bioassay , BP inhibited the ability of IFN-gamma but not or TNF-alpha to *induce* [CD54] expression on epithelial cells . Positive_regulation ICAM1 IL1B 12711326 1083266 To investigate whether TGZ acts by affecting the ICAM-1/LFA-1 pathway and/or the Th1/Th2 cytokine balance in NOD mice , we analysed the *induced* [ICAM-1] expression on islet-cells and the LFA-1 , CD25 , IL-2 , IFN-gamma , IL-4 , and IL-10 expression on splenocytes . Positive_regulation ICAM1 IL1B 12711326 1083271 Thus , the prevention of autoimmune diabetes in NOD mice by TGZ seems to be associated with suppression of *induced* [ICAM-1] expression leading to a reduced vulnerability of pancreatic beta-cells during the effector stage of beta-cell destruction . Positive_regulation ICAM1 IL1B 12791316 1097684 From these results we suggest that *mediates* the major stimulus for [ICAM-1] induction which is possibly a necessary but not sufficient step in the process of beta-cell destruction . Positive_regulation ICAM1 IL1B 12824917 1104404 Exogenous *enhanced* expression of various cytokines ( IL-6 , IL-8 , and vascular endothelial growth factor ( VEGF ) ) and intracellular adhesion molecule-1 ( [ICAM-1] ) by A549 , PC14 , RERF-LC-AI , and SBC-3 cells expressing IL-1 receptors . Positive_regulation ICAM1 IL1B 1347198 179207 We conclude from these data that although PMA induced ICAM-1 expression may be triggered through activation of protein kinase C , [ICAM-1] *induction* by , TNF-alpha , or LPS may involve distinct regulatory pathway ( s ) . Positive_regulation ICAM1 IL1B 1357985 200316 *Induction* of [ICAM-1] by TNF-alpha , , and LPS in human endothelial cells after downregulation of PKC . Positive_regulation ICAM1 IL1B 1357985 200319 The [intercellular adhesion molecule 1] ( ICAM-1 ) is *induced* on endothelial cells by tumor necrosis factor-alpha (TNF-alpha) , , and lipopolysaccharide (LPS) . Positive_regulation ICAM1 IL1B 1362041 206278 Interferon-gamma and significantly *increased* [ICAM-1] surface expression by HT-29 cells in a dose dependent manner . Positive_regulation ICAM1 IL1B 14762100 1250780 NCX-4016 , but not aspirin , decreased DNA binding of nuclear factor-kappaB (NF-kappaB) on gel shift analysis and HUVEC 's overexpression of [CD54] and CD62E *induced* by . Positive_regulation ICAM1 IL1B 15275879 1276746 TNF-alpha and *increased* [ICAM-1] expression in both control and Crohn 's disease . Positive_regulation ICAM1 IL1B 15275879 1276747 Pretreatment of fibroblasts with the Jun N-terminal kinase inhibitor dimethylaminopurine abolished TNF-alpha- and *stimulated* [ICAM-1] expression . Positive_regulation ICAM1 IL1B 15389584 1354310 Involvement of p42/p44 MAPK , JNK , and NF-kappaB in *induced* [ICAM-1] expression in human pulmonary epithelial cells . Positive_regulation ICAM1 IL1B 15389584 1354311 Here , the roles of mitogen activated protein kinases ( MAPKs ) and NF-kappaB pathways for *induced* [ICAM-1] expression were investigated in A549 cells . Positive_regulation ICAM1 IL1B 15389584 1354312 *induced* expression of [ICAM-1] protein and mRNA in a time- and concentration dependent manner . Positive_regulation ICAM1 IL1B 15389584 1354313 U0126 was more potent than other inhibitors to attenuate *induced* [ICAM-1] expression . Positive_regulation ICAM1 IL1B 15389584 1354327 Moreover , transfection with dominant negative mutants of MEK1/2 ( MEK K97R ) or ERK2 ( ERK2 K52R ) also attenuated *induced* [ICAM-1] expression . Positive_regulation ICAM1 IL1B 15389584 1354328 The combination of PD98059 and SP600125 displayed an additive effect on *induced* [ICAM-1] gene expression . Positive_regulation ICAM1 IL1B 15389584 1354329 *induced* [ICAM-1] expression was almost completely blocked by a specific NF-kappaB inhibitor helenalin . Positive_regulation ICAM1 IL1B 15389584 1354336 Taken together , these results suggest that activation of p42/p44 MAPK and JNK cascades , at least in part , mediated through NF-kappaB pathway is essential for *induced* [ICAM-1] gene expression in A549 cells . Positive_regulation ICAM1 IL1B 15720567 1376531 Although TNF-alpha and , at concentrations a little higher than those in sera of periodontitis patients , *up-regulated* the expression of [intercellular adhesion molecule-1] and vascular cell adhesion molecule-1 , P. gingivalis antigens had only a slight stimulatory effect . Positive_regulation ICAM1 IL1B 15797891 1403774 In cultured tubular epithelial cells , rosiglitazone significantly decreased the expression of [ICAM-1] and VCAM-1 *induced* by TNF-alpha or , inhibited the degradation of inhibitor kappaBalpha ( IkappaBalpha ) and blocked the activation of the p65 subunit of nuclear factor (NF)-kappaB . Positive_regulation ICAM1 IL1B 16249517 1471762 Stimulation of hRVECs with VEGF ( 165 ) , TNFalpha , or for 6 to 24 hours *caused* significant induction of [intracellular adhesion molecule (ICAM)-1] and vascular cell adhesion molecule (VCAM)-1 expression . Positive_regulation ICAM1 IL1B 1673988 155036 IFN-alpha and , however , *induced* only small increases in [ICAM-1] expression and enhanced the lysis of the A375 cells but not the HT-29 cells by monocytes . Positive_regulation ICAM1 IL1B 1680858 166557 Expression of [ICAM-1] on the surface of human umbilical vein endothelial cells and a human lung carcinoma cell line ( A549 ) was *increased* by , tumor necrosis factor alpha , and interferon gamma in a concentration dependent manner . Positive_regulation ICAM1 IL1B 1680858 166558 The 2'-O-methyl phosphorothioate analog of ISIS 1939 did not significantly reduce *induced* [ICAM-1] expression , whereas the 2'-O-methyl phosphorothioate analog of ISIS 1570 did inhibit ICAM-1 expression , suggesting that the reduction of ICAM-1 mRNA following treatment with ISIS 1939 was due , in part , to RNase H-mediated hydrolysis . Positive_regulation ICAM1 IL1B 1681812 169074 Combinations of IFN gamma + TNF alpha and IFN gamma + *had* a synergistic effect on [intercellular adhesion molecule 1] ( ICAM-1 ) expression and adhesion . Positive_regulation ICAM1 IL1B 16847181 1588139 The messenger RNA expressions of LARC ( liver and activation regulated chemokine ) , GMCSF ( granulocyte-macrophage colony stimulating factor ) , epiregulin , [ICAM1] ( intercellular adhesion molecule 1 ) , and TGFA ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation ICAM1 IL1B 16936090 1608912 Lipopolysaccharide (LPS) *induced* the release of the proinflammatory cytokine IL-6 and that of the chemokines G-CSF , MCP-1 , MIP-1beta , and IL-8 as well as surface expression of [ICAM-1] by corneal fibroblasts , whereas , TNF-alpha , and GM-CSF were not detected in the culture supernatants of cells incubated with or without LPS . Positive_regulation ICAM1 IL1B 1701992 145095 We found that , tumor necrosis factor alpha (TNF alpha) , and interferon-gamma (IFN gamma) each *increased* the cell surface expression of [intercellular adhesion molecule 1] ( ICAM-1 ) on human synovial fibroblasts in a dose- and time dependent manner . Positive_regulation ICAM1 IL1B 17072061 1637715 NAC inhibited the *stimulated* [ICAM-1] expression and IL-8 release from both cell lines in a concentration dependent manner . Positive_regulation ICAM1 IL1B 17119390 1652174 Guggulsterone significantly inhibited LPS- or *induced* [ICAM-1] gene expression , NF-kappaB transcriptional activity , IkappaB phosphorylation/degradation , and NF-kappaB DNA binding activity in IEC . Positive_regulation ICAM1 IL1B 17238806 1664240 TNF-alpha , IFN-gamma , and significantly *increased* the production of [ICAM-1] by both primary cultured human conjunctival cells and Chang conjunctival cells . Positive_regulation ICAM1 IL1B 17238806 1664243 Glucosamine sulfate effectively downregulated the production of [ICAM-1] *induced* by TNF-alpha , IFN-gamma , , TNF-alpha plus IFN-gamma , or TNF-alpha plus IL-1beta . Positive_regulation ICAM1 IL1B 17275031 1733243 VIP inhibited *induced* expression of [ICAM-1] in a dose dependent manner . Positive_regulation ICAM1 IL1B 17275031 1733244 The *induced* [ICAM-1] was also inhibited by a potent inhibitor of NF-kappaB , MG132 . Positive_regulation ICAM1 IL1B 17275031 1733246 VIP has an inhibitory effect on *induced* [ICAM-1] expression in SFs , which may be associated with NF-kappaB activity . Positive_regulation ICAM1 IL1B 17299794 1718819 Transactivation of Src , PDGF receptor , and Akt is involved in *induced* [ICAM-1] expression in A549 cells . Positive_regulation ICAM1 IL1B 17299794 1718822 Here , we further investigated whether these different mechanisms participating in *induced* [ICAM-1] expression in A549 cells . Positive_regulation ICAM1 IL1B 17299794 1718827 We initially observed that *induced* [ICAM-1] promoter activity was attenuated by the inhibitors of Src ( PP1 ) , PDGFR ( AG1296 ) , PI3-K ( LY294002 and wortmannin ) , and Akt ( SH-5 ) , revealed by reporter gene assay , Western blotting , and RT-PCR analyses . Positive_regulation ICAM1 IL1B 17299794 1718831 The involvement of Src and PI3-K/Akt in *induced* [ICAM-1] expression was significantly attenuated by transfection of A549 cells with dominant negative plasmids of Src , p85 and Akt , respectively . Positive_regulation ICAM1 IL1B 17299794 1718848 These results suggested that Akt phosphorylation mediated through transactivation of Src/PDGFR promotes the transcriptional p300 activity and eventually leads to [ICAM-1] expression *induced* by . Positive_regulation ICAM1 IL1B 17332440 1747953 Peptidoglycan ( PGN ) ( TLR2 ligand ) , flagellin ( TLR5 ligand ) , and Imiquimod R837 ( TLR7 ligand ) could significantly upregulate cell surface expression of [intercellular adhesion molecule (ICAM)-1] and CD18 , and *induce* the release of , IL-6 , IL-8 , growth related oncogene ( GRO ) -alpha , and superoxides of eosinophils . Positive_regulation ICAM1 IL1B 17349082 1707996 In the present study , we investigated the effects of EA on the formation of intracellular reactive oxygen species , the translocation of NFkappaB and expression of vascular cell adhesion molecule-1 ( VCAM-1 ) , [intercellular adhesion molecule-1] and endothelial leucocyte adhesion molecule ( E-selectin ) *induced* by in human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation ICAM1 IL1B 17693924 1882314 Lastly , inhibition of exportin 1 attenuates monocyte chemoattractant protein , IL-8 , and [intercellular adhesion molecule] expression in *response* to stimulation . Positive_regulation ICAM1 IL1B 17961823 1815128 Small-molecule library screening to find compounds that inhibit TNFalpha induced , but not *induced* , [intercellular adhesion molecule 1] ( ICAM-1 ) expression in lung epithelial cells identified a class of triazoloquinoxalines . Positive_regulation ICAM1 IL1B 18485347 1921711 Furthermore , western blot analysis revealed that overexpression of DSCR1-4 in SK-N-SH neuroblastoma cells attenuated *induced* cyclooxygenase 2 and [intercellular adhesion molecule 1] expression . Positive_regulation ICAM1 IL1B 18586957 1953589 Collectively , these results indicate that repression of *induced* [ICAM-1] expression and GM-CSF release by cAMP elevating agents , including beta(2)-adrenoceptor agonists , may not occur through a generic effect on NF-kappaB . Positive_regulation ICAM1 IL1B 18587424 1979181 PMX464 reduced ICAM-1 , GM-CSF and CXCL8 expression in *stimulated* A549 cells and [ICAM-1] in HLMVEC . Positive_regulation ICAM1 IL1B 18982426 2105739 Quercetin inhibits *induced* [ICAM-1] expression in pulmonary epithelial cell line A549 through the MAPK pathways . Positive_regulation ICAM1 IL1B 19278584 2046335 significantly *augmented* [ICAM-1] mRNA level at 4 hours and expression of ICAM-1 on A549 cell surface at 24 hours ( both P < 0.01 ) . Positive_regulation ICAM1 IL1B 19357230 2081165 Lipoxin A4 inhibits *induced* IL-8 and [ICAM-1] expression in 1321N1 human astrocytoma cells . Positive_regulation ICAM1 IL1B 19357230 2081167 As shown by quantitative RT-PCR , LXA ( 4 ) ( 10 nM ) significantly inhibited ( P < 0.05 ) the *induced* stimulation of IL-8 and [ICAM-1] expression in these cells . Positive_regulation ICAM1 IL1B 20432452 2268141 *induces* [ICAM-1] expression enhancing leukocyte adhesion in human rheumatoid arthritis synovial fibroblasts : involvement of ERK , JNK , AP-1 , and NF-kappaB . Positive_regulation ICAM1 IL1B 20432452 2268143 Here , we demonstrated that *induces* [ICAM-1] gene expression via the de novo protein synthesis through transcription and translation , which is attenuated by pretreatment with actinomycin D and cycloheximide , respectively . Positive_regulation ICAM1 IL1B 20432452 2268153 *stimulated* [ICAM-1] gene expression was attenuated by pretreatment with U0126 , SP600125 , tanshinone IIA , or helenalin , revealed by ICAM-1 promoter assay and real-time RT-PCR analysis . Positive_regulation ICAM1 IL1B 20432452 2268155 These results suggest that in human RASFs , activation of ERK , JNK , AP-1 , and NF-kappaB are essential for *induced* [ICAM-1] expression and leukocyte adhesion . Positive_regulation ICAM1 IL1B 23130331 2696472 IFN-alpha also significantly suppressed *induced* [intercellular adhesion molecule-1] ( ICAM-1 ) expression on HUVECs . Positive_regulation ICAM1 IL1B 7516927 261673 Tumour necrosis factor (TNF)alpha , interleukin (IL)1 alpha , and IL6 also *up-regulated* the expression of [CD54] in all the cell lines but CD40 was unaffected . Positive_regulation ICAM1 IL1B 7523818 272284 These findings suggest that , one of mediators in chronic sinusitis , is produced by PMNs , *induces* the expression of [ICAM-1] and ELAM-1 on endothelial cells , and , thereby , stimulates PMN infiltration in chronic sinusitis . Positive_regulation ICAM1 IL1B 7538427 301295 In parallel , DHA inhibited TNF-alpha stimulated monocytic U937 cell adhesion to HUVECs but did not affect TNF-alpha- or interferon gamma induced expression of [intercellular adhesion molecule-1] and endothelial leukocyte adhesion molecule-1 or VCAM-1 *induction* by . Positive_regulation ICAM1 IL1B 7545398 318539 The *induced* expression of [intercellular adhesion molecule 1] ( ICAM-1 ) , vascular cell adhesion molecule 1 ( VCAM-1 ) and E-selectin 1 ( ELAM-1 ) on SMCs was examined by reverse transcription/polymerase chain reaction ( RT/PCR ) . Positive_regulation ICAM1 IL1B 7813562 285225 [ICAM-1] expression on the surface of human umbilical vein endothelial cells was increased significantly by *stimulation* with , tumor necrosis factor alpha (TNF alpha) , thrombin and platelet activating factor (PAF) . Positive_regulation ICAM1 IL1B 7823534 285679 The *up-regulation* of [ICAM-1] expression by was detected at almost equal levels under hypoxia , and H/R. Using lucigenin-chemiluminescence , we demonstrated superoxide generation from HUVEC under H/R . Positive_regulation ICAM1 IL1B 7867034 287295 actively *regulates* functional [ICAM-1] expression in vascular smooth muscle cells . Positive_regulation ICAM1 IL1B 7867034 287297 The *induced* expression of [ICAM-1] on the smooth muscle cells may be an important contributor to the increased adhesion by monocytes and neutrophils to these cells and suggests that IL-1 beta might play a role in the proinflammatory and immune functions of the modified smooth muscle cells during atherosclerosis and restenosis . Positive_regulation ICAM1 IL1B 7910170 254303 Nuclear run-on analysis demonstrated that the ICAM-1 gene is transcribed under basal conditions in astrocytes , and that both TNF-alpha and *enhance* transcriptional activation of the [ICAM-1] gene . Positive_regulation ICAM1 IL1B 7912003 257860 ( 100 U/ml ) and dibutyryl-cyclic-GMP ( 0.01 mM ) both *induced* an increase in the expression of [intercellular adhesion molecule-1] by endothelial cells . Positive_regulation ICAM1 IL1B 7915252 269698 [ICAM-1] expression was *enhanced* by , TNF-alpha , and most effectively by IFN-gamma . Positive_regulation ICAM1 IL1B 7915999 269787 and TNF-alpha induced a parallel *increase* of both the [ICAM-1] expression on EC and sICAM-1 production by EC , while IFN-gamma induced only the dose dependent enhancement of ICAM-1 expression , but not the production of sICAM-1 , IL-4 and IL-6 did not show any effects on the ICAM-1 expression nor on the sICAM-1 production . Positive_regulation ICAM1 IL1B 7945915 276579 Both the normal and systemic sclerosis dermal fibroblasts increased their cell surface expression of [ICAM-1] in *response* to , tumor necrosis factor-alpha (TNF-alpha) , and interferon-gamma (IFN-gamma) in a dose dependent fashion . Positive_regulation ICAM1 IL1B 8097520 217652 TNF-alpha and also *increased* the expression of [ICAM-1] on MMG2 . Positive_regulation ICAM1 IL1B 8099361 219995 [ICAM-1] expression *induced* by , rabbit IL-1 beta 208-240 and human IL-1 beta 208-240 was blocked by the IL-1ra , while TNF alpha- and IFN gamma induced ICAM-1 expression were not . Positive_regulation ICAM1 IL1B 8099361 219996 [ICAM-1] expression *induced* by and human IL-1 beta 208-240 was also blocked by the sIL-1R . Positive_regulation ICAM1 IL1B 8105755 231411 Corticosteroids induce proliferation but do not influence TNF- or *induced* [ICAM-1] expression of human dermal microvascular endothelial cells in vitro . Positive_regulation ICAM1 IL1B 8105755 231413 TNF and were strong *inducers* of [ICAM-1] expression on 74 % and 82 % of the cells , respectively . Positive_regulation ICAM1 IL1B 8607877 352665 However , the upregulation of [ICAM-1] mRNA levels in *response* to was much more stable than the transient induction of E-selectin and VCAM-1 transcripts . Positive_regulation ICAM1 IL1B 8639172 362513 We found that AECA IgG from WG patients do not display any significant cytotoxicity but are able to up-regulate the expression of E-selectin , [intercellular adhesion molecule 1] and vascular cell adhesion molecule 1 and to *induce* the secretion of , IL-6 , IL-8 , and MCP-1 . Positive_regulation ICAM1 IL1B 8660354 367037 Stimulation with for a further 16 h *increased* the levels of [intercellular adhesion molecule-1] , and this effect was inhibited by co-incubation with 0.1-1 microM dexamethasone . Positive_regulation ICAM1 IL1B 8752943 374385 TGF-beta alone has a minimal effect on constitutive ICAM-1 expression in either astrocytes or microglia , but inhibits , in a time dependent manner , TNF-alpha- or *induced* [ICAM-1] mRNA and protein expression in astrocytes . Positive_regulation ICAM1 IL1B 8752943 374387 Inhibition of TNF-alpha- or *induced* [ICAM-1] mRNA levels by TGF-beta in astrocytes was not due to degradation of ICAM-1 message , rather , inhibition was mediated at the transcriptional level . Positive_regulation ICAM1 IL1B 8752943 374389 TGF-beta inhibited TNF-alpha- and *induced* [ICAM-1] expression , but IFN-gamma induction of ICAM-1 was unaffected . Positive_regulation ICAM1 IL1B 8777267 366019 [ICAM-1] expression on mesangial cells was *stimulated* significantly by , but not by IL-6 nor IL-8 , in a dose dependent manner . Positive_regulation ICAM1 IL1B 8785389 371454 Stimulation with or TNF alpha *resulted* in time- and dose dependent upregulation of [ICAM-1] mRNA transcript and increased cell-surface immunoreactive protein expression . Positive_regulation ICAM1 IL1B 8915982 395835 In an enzyme linked immunosorbent assay , ( IL-1 beta ; 10 ng/mL ) *increased* [ICAM-1] molecule expression on cultured rat mesangial cell surface in a time dependent manner . Positive_regulation ICAM1 IL1B 8915982 395836 Addition of the nitric oxide donors 3-morpholino-sydnonimine ( SIN-1 ) or sodium nitroprusside significantly suppressed *induced* [ICAM-1] molecule expression in a dose dependent manner . Positive_regulation ICAM1 IL1B 8915982 395837 Addition of 8-bromo-cyclic GMP showed no significant effect on *induced* [ICAM-1] expression . Positive_regulation ICAM1 IL1B 8915982 395838 In Northern blot analysis , the expression of ICAM-1 mRNA was barely detected in unstimulated cells , whereas ICAM-1 gene transcripts were clearly expressed after exposure to IL-1 beta for 3 h , and addition of SIN-1 decreased *induced* [ICAM-1] mRNA accumulation . Positive_regulation ICAM1 IL1B 8932586 398012 Human keratinocytes derived from skin obtained during plastic surgery were cultured in defined medium ( MCDB 153 ) and were stimulated by SP. Flow cytometry analysis showed that SP ( 10 ( -7 ) and 10 ( -5 ) M ) as well as the specific NK1 agonist Sar9Met ( O2 ) 11SP ( Sar Met ) induced a slight but significant expression of [ICAM-1] at the cell surface during treatment periods of 24 h and 48 h. SP ( 10 ( -5 ) M ) also *induced* a significant but transient increase in the production of IL-1alpha , , IL-1 receptor antagonist and IL-8 which was detectable by ELISA techniques 6 h after stimulation . Positive_regulation ICAM1 IL1B 8943419 400031 Cross linking of [intercellular adhesion molecule 1] ( CD54 ) *induces* AP-1 activation and transcription . Positive_regulation ICAM1 IL1B 8943419 400035 In this study , we provide the first evidence that [ICAM-1] engagement *induces* activation of the transcription factor AP-1 and transcription of the gene using a specific Ab to cross-link ICAM-1 on a rheumatoid synovial cell line ( E11 cells ) . Positive_regulation ICAM1 IL1B 9008098 405037 Cell surface enzyme immunoassay showed that INFnu , , or TNF alpha *stimulated* expression of [ICAM-1] , or VCAM-1 on MC after 24 hours . Positive_regulation ICAM1 IL1B 9030094 413759 Failure to block biosynthesis of E-selectin and [ICAM-1] *induced* by TNF-alpha and indicates the inhibitory effect exerted by serotonin was selective in nature . Positive_regulation ICAM1 IL1B 9047077 406002 Both [ICAM-1] and VCAM-1 expression were *increased* markedly by . Positive_regulation ICAM1 IL1B 9047077 406004 This mediated *induction* of [ICAM-1] and VCAM-1 expression was significantly inhibited in the presence of a NO donor 3-morpholino-sydnonimine ( SIN-1 ) in a dose dependent manner . Positive_regulation ICAM1 IL1B 9047077 406006 The inhibitory effect of SIN-1 was abolished in the presence of a NO scavenger haemoglobin , while addition of 8-bromo-cGMP showed no significant effect on *induced* [ICAM-1] or VCAM-1 expression . Positive_regulation ICAM1 IL1B 9047077 406008 Northern blot analysis showed that markedly *increased* [ICAM-1] and VCAM-1 mRNA expression , while SIN-1 decreased the accumulation of these transcripts induced by IL-1 beta . Positive_regulation ICAM1 IL1B 9106260 424460 Since adhesion molecules ( AM ) induced on endothelial cells ( EC ) play an important role in T-cell migration into the CNS , the objective of this study was to examine the effect of IFN beta-1b on the expression of the AM , [ICAM-1] , V-CAM and E-selection *induced* on EC by IFN-gamma , TNF-alpha , or . Positive_regulation ICAM1 IL1B 9194690 438179 M-PSL also inhibited *induced* upregulation of E-selectin and [ICAM-1] on HUVEC in a dose dependent manner . Positive_regulation ICAM1 IL1B 9197378 438549 In addition , pretreatment of infected monocytes with a TNF-alpha synthesis inhibitor , RP 55778 , or with MAbs directed against IL-1beta , confirmed the *role* of TNF-alpha and in the regulation of CD18 , CD44 , and [CD54] expression . Positive_regulation ICAM1 IL1B 9227560 443310 Pretreatment of neutrophils with SNAP or 8-bromoguanosine 3',5'-cyclic monophosphate did not reduce PAF induced CD11b/CD18 expression determined by flow cytometry , nor did simultaneous treatment of myocytes with IL-1 beta and SNAP decrease *induced* [intercellular adhesion molecule-1] expression determined by immunofluorescence staining and enzyme linked immunosorbent assay . Positive_regulation ICAM1 IL1B 9234165 445252 Its 50 % inhibitory concentrations ( IC50 ) for the *induced* ELAM-1 and [ICAM-1] expressions were 2.3 x 10 ( -5 ) M and 4.0 x 10 ( -5 ) M , respectively . Positive_regulation ICAM1 IL1B 9234165 445258 In addition , protein C-kinase ( PKC ) inhibitor H7 also inhibited the ELAM-1 and [ICAM-1] expressions *induced* by and TNF-alpha . Positive_regulation ICAM1 IL1B 9266024 449366 and TNF-alpha synergistically *increased* the expression of [ICAM-1] , but they failed to induce MHC molecules . Positive_regulation ICAM1 IL1B 9357849 462069 Immunohistochemical studies revealed that both HRV-14 infection and *increased* [ICAM-1] expression on cultured epithelial cells . Positive_regulation ICAM1 IL1B 9409229 471406 In cultured human smooth muscle cells from coronary arteries and saphenous veins , tumor necrosis factor-alpha (TNF-alpha) and *induced* the expression of [intercellular adhesion molecule] ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation ICAM1 IL1B 9409229 471439 Cicaprost as well as forskolin significantly inhibited TNF-alpha- and *induced* cell surface expression of [ICAM-1] and VCAM-1 . Positive_regulation ICAM1 IL1B 9448041 483780 TNF-alpha and *increased* the expression of [ICAM-1] , E-selectin , and VCAM-1 , whereas IL-4 induced only that of VCAM-1 . Positive_regulation ICAM1 IL1B 9523024 493883 Coincubation of neutrophils with alpha-Toc and pretreatment of HUVEC with alpha-Toc significantly reduced PAF induced CD11b/CD18 expression and *induced* upregulation of [ICAM-1] and VCAM-1 , respectively . Positive_regulation ICAM1 IL1B 9529162 496515 We also found that inhibition of tyrosine kinase and p38/RK ( stress activated protein kinase ) pathways prevented *induced* [ICAM] and VCAM protein synthesis , whereas extracellular signal regulated protein kinase ( ERK1/ERK2 ) inhibition did not . Positive_regulation ICAM1 IL1B 9529162 496520 However , hypoxia did enhance *induced* [ICAM] mRNA expression in myocytes . Positive_regulation ICAM1 IL1B 9610617 508781 *induced* MCP-1 , CINC , RANTES and [ICAM-1] gene expression in a time dependent manner . Positive_regulation ICAM1 IL1B 9655736 516553 *enhanced* the [intercellular adhesion molecule-1] ( ICAM-1 ) expression assessed by immunohistochemical analysis and susceptibility of epithelial cells to HRV-14 infection . Positive_regulation ICAM1 IL1B 9705828 526079 *induced* [ICAM-1] , and COX activity , while it had no affect on VCAM-1 . Positive_regulation ICAM1 IL1B 9751850 533696 HNMEC differed from human umbilical vein endothelila cells in that ( 1 ) maximal upregulation of [ICAM-1] expression *induced* by or TNF-alpha required more time ( 2 ) TNF-alpha was more potent than IL-1beta in VCAM-1 expression , and ( 3 ) dexamethasone inhibited the upregulation of E-selectin expression alone . Positive_regulation ICAM1 IL1B 9831176 551461 increased both MCP-1 and IL-8 release , and *increased* the expression of [ICAM-1] and CD40 , but not HLA class II molecules . Positive_regulation ICAM1 IL1B 9831176 551472 In addition , and particularly IFN-gamma *increase* the expression of [ICAM-1] , HLA class II and/or CD40 molecules , which are involved in the adhesion and possibly activation of the recruited leukocytes . Positive_regulation ICAM1 IL1B 9832620 551978 *enhanced* the production of IL-6 and stromelysin-1 , and the surface expression of [ICAM-1] , in a manner similar to that in the parental FLSs . Positive_regulation ICAM1 IL1B 9888295 585084 TNF-alpha and *enhanced* [ICAM-1] expression at both the mRNA and protein levels , while IFN-gamma had a modest enhancing effect . Positive_regulation ICAM1 IL1B 9973188 560260 Auranofin ( AF ) interacted with HUVEC and PMN adhesiveness but in opposite directions : this drug hampered *induced* HUVEC hyperadhesiveness and expression of E-selectin and [intercellular adhesion molecule 1] , but augmented PMN adherence and CD18 expression . Positive_regulation ICAM1 ITGAL 10639327 660463 Low-affinity interactions *augment* [LFA-1/ICAM-1] mediated T cell adhesion and signaling by redistribution of LFA-1 . Positive_regulation ICAM1 ITGAL 2538244 108334 A major group rhinovirus binds specifically to purified [ICAM-1] and to ICAM-1 expressed on transfected COS cells , and binding is *blocked* by three ICAM-1 monoclonal antibodies ( MAb ) that block interaction , but not by an ICAM-1 MAb that does not block ICAM-1-LFA-1 interaction . Positive_regulation ICAM1 ITGB2 10601245 574309 We report here that *mediated* binding of mouse thymocytes or activated T lymphocytes to [intercellular adhesion molecule 1] can be rapidly induced by clustering of membrane rafts using antibodies to the glycosylphophatidylinositol anchored molecule CD24 or cholera toxin ( CTx ) . Positive_regulation ICAM1 ITGB2 10639327 660466 We found that *mediated* [ICAM-1] cell-cell interactions such as T cell proliferation greatly depend on low affinity LFA-1/ICAM-3 interactions that enhance stable LFA-1/ICAM-1 cell-cell contact . Positive_regulation ICAM1 ITGB2 10639327 660468 Taken together , these data demonstrate that low affinity binding to ICAM-3 *regulates* strong [LFA-1/ICAM-1] mediated adhesion by driving LFA-1 into clusters to facilitate cell-cell interactions that take place in the immune system . Positive_regulation ICAM1 ITGB2 1356124 195879 In this assay , the protein kinase C-activating phorbol ester PDB and anti-IgM antibodies , as well as the protein kinase inhibitor , staurosporine , were able to induce *dependent* binding to [ICAM-1] . Positive_regulation ICAM1 ITGB2 14702343 1218991 PLC-gamma1-deficient Jurkat T cells showed a marked reduction of TCR triggered Rap1 activation and adhesion to [intercellular adhesion molecule-1] ( ICAM-1 ) *mediated* by . Positive_regulation ICAM1 ITGB2 15661900 1365112 In this study , we show that Ab-mediated cross linking of the PSGL-1 on Th1 cells enhances *dependent* cell binding to [ICAM-1] . Positive_regulation ICAM1 ITGB2 20805842 2401412 We further show that exposure of human DCs to the lymphoid chemokine CCL21 specifically restores the high-affinity form of and *induces* binding to its ligand [ICAM-1] under low shear stress . Positive_regulation ICAM1 ITGB2 7587805 333804 These results suggest that neutrophil-endothelial adhesive interactions , which occur via CD11a/ CD18- and *dependent* interactions with [intercellular adhesion molecule-1] , and oxygen derived free radicals produced by neutrophils are implicated in the production of aspirin induced gastric mucosal injury . Positive_regulation ICAM1 ITGB2 7608563 311949 Stimulation of neutrophils with CBR *induces* binding to [ICAM-1] through activation of both LFA-1 and Mac-1 . Positive_regulation ICAM1 ITGB2 7901109 234433 These studies suggest that products of H. pylori elicit gastrointestinal inflammation by promoting PMN adhesion to endothelial cells via CD11a/CD18- and *dependent* interactions with [ICAM-1] . Positive_regulation ICAM1 ITGB2 7905020 245785 Two ICAM-3 mAbs , CBR-IC3/1 and CBR-IC3/2 , were required to block LFA-1 dependent adhesion to purified ICAM-3- or *dependent* , [ICAM-1-] , ICAM-2 independent homotypic adhesion of lymphoid cell lines . Positive_regulation ICAM1 ITGB2 8103026 225991 These studies indicate that aspirin promotes neutrophil adherence to endothelium via CD11a/CD18- and *dependent* interactions with [intercellular adhesion molecule 1] ; Positive_regulation ICAM1 ITGB2 8774994 344298 Recent studies have indicated that aspirin promotes neutrophil adherence to endothelium via *dependent* interactions with [intercellular adhesion molecule 1] , which subsequently leads to neutrophil mediated cell injury . Positive_regulation ICAM1 ITGB2 8977199 408717 Functional studies with the parental cell lines , the J- ( beta2 ) .7 and SK- ( beta2 ) .7 cells , and the transfectants showed that all binding of Jurkat and SKW3 cells to purified [ICAM-1] is *mediated* by , and the reconstituted LFA-1 expressed by the J- ( beta2 ) .7 and SK- ( beta2 ) .7 transfected cells is regulated normally . Positive_regulation ICAM1 ITGB2 8995280 409439 With respect to other ligands , mAbs 1G12 and 2D5 completely inhibited attachment of Plasmodium falciparum infected erythrocytes to immobilized recombinant ICAM-1-Fc , whereas they had no effect on *dependent* T cell binding to [ICAM-1-Fc] . Positive_regulation ICAM1 ITGB2 9523024 493867 PAF *induced* upregulation of CD11b and on neutrophils and IL-1 beta increased surface expression of [ICAM-1] and VCAM-1 on HUVEC . Positive_regulation ICAM1 ITGB2 9724052 529352 The expression of [ICAM-1] was *detected* on both preosteoclasts and osteoclast-like MNCs , whereas the expression of was restricted to preosteoclasts . Positive_regulation ICAM1 LBP 16123407 1449370 However , sCD14 or *enhanced* the LPS induced upregulation of [ICAM-1] and the chemokines interleukin-8 and monocyte chemoattractant protein (MCP)-1 in these cells at the protein and mRNA levels . Positive_regulation ICAM1 LBP 18363879 1925404 Our study also revealed that the LOS induced surface [ICAM-1] expression was partially mediated through a TNF-alpha dependent autocrine mechanism and could be further *augmented* by in serum . Positive_regulation ICAM1 MAP2K6 17982228 1821097 However , neither p38 MAP kinase inhibitor nor inhibitor *prevented* HDM induced [ICAM-1] expression in EoL-1 cells . Positive_regulation ICAM1 MAP2K6 21391218 2521341 avß3 and avß5 integrin monoclonal antibody and inhibitors ( PD98059 and U0126 ) *inhibited* the CCN6 induced increase of the migration and [ICAM-1] up-regulation of chondrosarcoma cells . Positive_regulation ICAM1 MAP2K6 22845610 2677006 Endothelial Japanese encephalitis virus infection enhances migration and adhesion of leukocytes to brain microvascular endothelia via *dependent* expression of [ICAM1] and the CINC and RANTES chemokines . Positive_regulation ICAM1 PECAM1 18939362 1978035 Combination of 20 ng/ml TNF-alpha with 50 ng/ml IGF-1 *enhances* expression of [CD54] to 96.8 +/- 1.2 % , with 200 ng/ml IGF-1 enhances and CD54 expression respectively to 90.5 +/- 2.3 % and 96.6 +/- 0.6 % . Positive_regulation ICAM1 PECAM1 19714308 2127455 Significant radiation induced increase of [ICAM-1] ( intercellular adhesion molecule-1 ) , VCAM-1 ( vascular cell adhesion molecule-1 ) , JAM-1 ( junctional adhesion molecule-1 ) , beta1-integrin , beta2-integrin , E-cadherin , and P-selectin gene expression could be *detected* in vivo , while ( platelet-endothelial cell adhesion molecule-1 ) gene expression remained unchanged . Positive_regulation ICAM1 PLAT 19638998 2149981 In addition , adjuvant treatment with atorvastatin at 4 h and with tPA at 6 h reduced *induced* upregulation of protease activated receptor-1 , [intercellular adhesion molecule-1] , and matrix metalloproteinase-9 , and concomitantly reduced cerebral microvascular platelet , neutrophil , and fibrin deposition compared with rats treated with tPA alone at 6 h . Positive_regulation ICAM1 PLAU 16728704 1612370 In contrast , exogenous *stimulated* [ICAM] and VCAM adhesion of airway eosinophils . Positive_regulation ICAM1 RARB 7647034 318884 Heterodimeric and retinoid X receptor-alpha complexes *stimulate* expression of the [intercellular adhesion molecule-1] gene . Positive_regulation ICAM1 RCAN1 18485347 1921710 Furthermore , western blot analysis revealed that overexpression of in SK-N-SH neuroblastoma cells *attenuated* IL-1beta induced cyclooxygenase 2 and [intercellular adhesion molecule 1] expression . Positive_regulation ICAM1 SELL 10029177 591543 Despite the high level of cellular activation and proliferation induced by PMVEC coculture , the surface expression of adhesion molecules CD11a ( LFA-1 ) , CD11b , CD15s ( sialyl-Lewis x ) , CD43 , and CD44 ( HCAM ) on the total CD34+ population was maintained , and the surface expression of CD49d ( VLA-4 ) , CD54 ( [ICAM] ) , CD58 , and ( L selectin ) *increased* after ex vivo expansion . Positive_regulation ICAM1 SELL 7513985 253913 [intercellular adhesion molecule 1] was upregulated , and endothelial was *induced* on superficial dermal blood vessels . Positive_regulation ICAM1 SELL 7538427 301293 In parallel , DHA inhibited TNF-alpha stimulated monocytic U937 cell adhesion to HUVECs but did not affect TNF-alpha- or interferon gamma induced expression of [intercellular adhesion molecule-1] and endothelial or VCAM-1 *induction* by interleukin-1 beta . Positive_regulation ICAM1 SELL 8464084 215938 Surprisingly , expression of adhesion molecules endothelial and vascular cell adhesion molecule were not elevated , but [intercellular adhesion molecule-1] expression did *increase* in more severely diseased skin . Positive_regulation ICAM1 SELL 8879206 390712 We report here that either antibody mediated cross linking of on human lymphocytes or treatment of the cells with GlyCAM-1 , an HEV derived , secreted ligand for L-selectin , *stimulates* their binding to [ICAM-1] through the beta 2 integrin pathway . Positive_regulation ICAM1 TLR7 17054926 1642070 Ligand activation of TLR2 , TLR4 and TLR5 , but not TLR3 , or TLR9 , *resulted* in cardiomyocyte expression of the inflammatory cytokine IL-6 , the chemokines KC and MIP-2 , and the cell surface adhesion molecule [ICAM-1] . Positive_regulation ICAM1 TLR7 21068089 2382736 dsRNA/poly ( I:C ) , but not other ligands , highly *stimulated* ET-1 protein and mRNA ( EDN1 ) , as well as [intercellular adhesion molecule-1] ( ICAM-1 ) and IFN regulated MX2 , by endothelial cells and dermal fibroblasts . Positive_regulation ICAM1 TNF 10073767 594698 produced a larger *increase* in [intercellular adhesion molecule-1] mRNA expression . Positive_regulation ICAM1 TNF 10082656 599106 Retinoic acid potentiates *induced* [ICAM-1] expression in normal human epidermal keratinocytes . Positive_regulation ICAM1 TNF 10082656 599109 RA potentiated the *induced* [ICAM-1] response in all Ca2+-concentrations . Positive_regulation ICAM1 TNF 10082656 599111 In summary , our results establish retinoic acid as an enhancer of *induced* [ICAM-1] levels in NHK . Positive_regulation ICAM1 TNF 10090156 600149 *increased* the expression of [ICAM-1] by RA and OA fibroblasts . Positive_regulation ICAM1 TNF 10199816 605358 also significantly *enhanced* surface expression of vascular cell adhesion molecule 1 and E-selectin ( in HUVEC only ) , as well as [intercellular adhesion molecule 1] ( ICAM-1 ; in HUVEC and ECV ) . Positive_regulation ICAM1 TNF 10199816 605359 Lactacystin attenuated *stimulated* [ICAM-1] expression in ECV . Positive_regulation ICAM1 TNF 10219841 609116 These results indicate that IFN-gamma and *induce* the expression of [ICAM-1] on parenchymal hepatocytes and that the LFA-1-ICAM-1 pathway plays an important role in the interaction between hepatocytes and neutrophils or lymphocytes . Positive_regulation ICAM1 TNF 10225829 610259 This compound , which is known to suppress *induced* [CD54] expression , inhibited the primary proliferative response of the T cell to antigen ( Ag ) -presenting cells ( APCs ) including allogenic dendritic cells (DCs) , autologous Epstein-Barr virus infected B cells , and human T lymphotropic virus type I ( HTLV-I ) -infected T cells . Positive_regulation ICAM1 TNF 10339475 615855 We found that overexpression of IkappaB-alpha in endothelial cells using a recombinant adenovirus prevented tumor necrosis factor-alpha (TNF-alpha) induced degradation of IkappaB-alpha and suppressed the *upregulation* of vascular cell adhesion molecule-1 ( VCAM-1 ) , [intercellular adhesion molecule-1] ( ICAM-1 ) , and E-selectin mRNA and surface protein expression and the upregulation of transcripts for the chemokines monocyte chemoattractant protein 1 ( MCP-1 ) and growth related activity-alpha ( GRO-alpha ) by . Positive_regulation ICAM1 TNF 10362686 620127 Hypoxia ( 95 % N2-5 % CO2 ) resulted in a downregulation of basal but not *induced* expression of [ICAM-1] and VCAM-1 . Positive_regulation ICAM1 TNF 10375758 561536 *induced* [ICAM-1] expression on the cell surface and endothelial adhesivity toward HL-60 cells were studied using human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation ICAM1 TNF 10395656 627480 Using rat astrocytes in culture , we report that [ICAM-1] binding by specific Abs *induces* secretion together with phosphorylation of the transcription factor cAMP response element binding protein . Positive_regulation ICAM1 TNF 10409231 629942 greater induction of [CD54] *resulted* from ( 45 +/- 2 % , P < 0.001 ) . Positive_regulation ICAM1 TNF 10425270 632806 In contrast , the pro-inflammatory cytokine , whose activity is dependent on the generation of intracellular ROS , *induces* IL-8 and [ICAM-1] in both cell types . Positive_regulation ICAM1 TNF 10430178 633560 *induced* both VCAM-1 and [ICAM-1] expression in human umbilical vein endothelial cells ( HUVECs ; Positive_regulation ICAM1 TNF 10430178 633563 and interleukin-1beta (IL-1beta) *stimulated* cell surface [ICAM-1] expression , but not VCAM-1 expression , in human aortic smooth muscle cells ( HASMCs ) . Positive_regulation ICAM1 TNF 10438953 635175 Although dexamethasone partially inhibited IL-1 beta- and *induced* up-regulation of [ICAM-1] at 4 h , dexamethasone had no effect on cytokine induced ICAM-1 expression at 18-24 h . Positive_regulation ICAM1 TNF 10443926 635851 In contrast , *induced* [intercellular adhesion molecule-1] ( ICAM-1 ) expression was not affected by the depletion of either cytoplasmic or mitochondrial GSH . Positive_regulation ICAM1 TNF 10484327 643967 These results suggest that quercetin downregulates both PMA- and *induced* [ICAM-1] expression via inhibiting both AP-1 activation and the JNK pathway . Positive_regulation ICAM1 TNF 10484438 644094 The dual radiolabeled monoclonal antibody technique was used to quantify constitutive and *induced* expression of [intercellular adhesion molecule 1] ( ICAM-1 ) , vascular cell adhesion molecule 1 ( VCAM-1 ) , ICAM-2 , P-selectin , E-selectin , and platelet-endothelial cell adhesion molecule 1 ( PECAM-1 ) in different vascular beds of normal ( C57Bl/6 ) and RM-1 tumor bearing mice . Positive_regulation ICAM1 TNF 10491002 645878 and IL-1 sequentially *induce* endothelial [ICAM-1] and VCAM-1 expression in MRL/lpr lupus-prone mice . Positive_regulation ICAM1 TNF 10495789 478589 Hydroxy-methoxy acetophenone , an inhibitor of NADPH dependent oxidase , also attenuated RANTES and [ICAM-1] in *response* to or IgG . Positive_regulation ICAM1 TNF 10549609 564996 Treatment with NAC clearly restrained *induced* [ICAM] expression on HUVEC , while preincubation of cells with PDTC showed synergistic effects . Positive_regulation ICAM1 TNF 10549609 565001 The inhibition of *induced* [ICAM-1] expression by NAC might have clinical implications because this substance is used as a radioprotector in radiotherapy . Positive_regulation ICAM1 TNF 10567951 567935 IFN-gamma elicited ICAM-1 expression was synergistically increased by PGF2 alpha , whereas *induced* [ICAM-1] expression was slightly inhibited by PGF2 alpha . Positive_regulation ICAM1 TNF 10573217 568779 IL-1beta ( optimal concentration ( OC ) 1 U x mL(-1) ) and ( OC 100 U x mL(-1) ) both *increased* [ICAM-1] and VCAM-1 expression . Positive_regulation ICAM1 TNF 10580548 570088 *Induction* of [intercellular adhesion molecule] ( ICAM-1 ) , vascular cell adhesion molecule ( VCAM-1 ) and E-selectin by , measured by a radiometric technique , was similar in IVEC and HUVEC , while the induction of E-selectin by IL-1beta on IVEC was limited and significantly different from that observed on HUVEC ( p < 0.001 ) . Positive_regulation ICAM1 TNF 10600091 573811 We examined the effects of estrogen on *induced* expression of intracellular adhesion molecule ( [ICAM-1] ) and vascular adhesion molecule ( VCAM-1 ) in cultured human bronchial smooth muscle cells ( BSMC ) . Positive_regulation ICAM1 TNF 10600091 573812 Incubation of BSMC with forskolin 5 microM , for 1 hour before TNF-alpha , decreased *induced* expression of [ICAM-1] by 62 % and VCAM-1 slightly by 17 % . Positive_regulation ICAM1 TNF 10600091 573813 The BSMC incubated with estradiol 30 microM , 1 hour before TNF-alpha , decreased *induced* expression of [ICAM-1] by 21 % ; Positive_regulation ICAM1 TNF 10600091 573814 We found a trend toward inhibition of *stimulated* [ICAM-1] expression in cultured BSMC with pretreatment with estradiol . Positive_regulation ICAM1 TNF 10644010 577708 It is well known that [ICAM-1] expression can be *stimulated* by and by oxidative stress , via the activation of specific transcription factors . Positive_regulation ICAM1 TNF 10644010 577712 Specific inhibition of Cu/Zn-SOD activity by DTIC ( diethyldithiocarbamic acid ) , in *presence* of Paraquat or , was followed by an upregulation of [ICAM-1] expression ( 60 and 20 % , respectively ) . Positive_regulation ICAM1 TNF 10644010 577714 In presence of TNF however , the same SOD mimetic inhibited *stimulated* [ICAM-1] expression by 25 % in melanoma and 17 % in endothelial cells . Positive_regulation ICAM1 TNF 10644010 577715 This increase seems to be associated with a reduction in the *stimulation* of [ICAM-1] expression by or oxidative stress . Positive_regulation ICAM1 TNF 10645917 661779 In endothelial cells , the PPARgamma agonists troglitazone at 100 micromol/L and 15-deoxy- ( Delta12,14 ) -prostaglandin J ( 2 ) ( 15d-PGJ2 ) at 20 micromol/L markedly attenuated the *induced* expression of VCAM-1 and [ICAM-1] . Positive_regulation ICAM1 TNF 10697805 579160 From these data , we suggest that PGE2 downregulates *induced* [ICAM-1] expression in HGF , via EP2 and EP4 receptors by cAMP dependent signaling pathways , which may result in control of inflammatory and immunological responses in periodontal disease . Positive_regulation ICAM1 TNF 10718114 676652 significantly *increased* [ICAM-1] expression in all cell types whereas SI elicited an increase in peritoneal macrophages ( PM ) and the cell line , MH-S . Positive_regulation ICAM1 TNF 10718114 676655 These data demonstrate that both inflammatory cytokines and inorganic particles can increase [ICAM-1] expression on mouse macrophages and that this expression is *mediated* , in part , by and reactive oxygen species . Positive_regulation ICAM1 TNF 10760953 683673 In the presence of ethanol , however , PRL- and *induced* increases in all four immunoreactive [ICAM-1] proteins were markedly inhibited . Positive_regulation ICAM1 TNF 10760953 683679 In the present report , we show that TNF-alpha increased ICAM-1 mRNA levels in human astrocytoma cells and that ethanol markedly blocked *induced* increases in [ICAM-1] mRNA levels . Positive_regulation ICAM1 TNF 10760953 683681 Further , we found that PRL induced [ICAM-1] expression was , at least in part , *due* to a PRL induced increase in syntheses and secretion . Positive_regulation ICAM1 TNF 10771568 686194 The expression of [ICAM-1] and E-selectin *induced* by was not inhibited by either bFGF or VEGF . Positive_regulation ICAM1 TNF 10773213 686369 Inhibition of protein kinase C counteracts *induced* [intercellular adhesion molecule 1] expression and fluid phase endocytosis on brain microvascular endothelial cells . Positive_regulation ICAM1 TNF 10797183 689790 The NF-kappaB TFD blocked the *induced* and H/R induced increase in [ICAM-1] mRNA levels and the upregulation of surface ICAM-1 . Positive_regulation ICAM1 TNF 10797183 689791 An NF-kappaB decoy blocks both *induced* and H/R induced [ICAM-1] upregulation in HBMEC . Positive_regulation ICAM1 TNF 10807781 692332 *induced* the expression of VCAM-1 , E-selectin , and [ICAM-1] but had no effect on P-selectin expression . Positive_regulation ICAM1 TNF 10837365 699388 *enhanced* [ICAM-1] surface expression ( measured by flow cytometry ) and steady-state messenger RNA ( mRNA ) levels ( assessed by Northern hybridization ) in concentration- and time dependent manners . Positive_regulation ICAM1 TNF 10837365 699389 The results support the following pathway , whereby *enhances* expression of [ICAM-1] in NHBE cells : TNF-alpha -- > TNF-RI -- > PC-PLC -- > DAG -- > PKC -- > ( NF-kappaB ? ) -- > ICAM-1 mRNA -- > ICAM-1 surface expression . Positive_regulation ICAM1 TNF 10849374 701157 The expression of CD54 and CD58 adhesion molecules on their surface appeared to influence their vulnerability , and the *induced* positive modulation of [CD54] increased osteosarcoma susceptibility in vitro . Positive_regulation ICAM1 TNF 10860946 704988 This rapid *induced* [ICAM-1] expression enhanced T-lymphocyte adhesion to ASM cells , which was inhibited by anti-ICAM-1 antibodies . Positive_regulation ICAM1 TNF 10860946 704991 In addition , chelating cytosolic calcium with 1,2-bis ( 2-aminophenoxy ) ethane-N , N,N ' , N'-tetraacetic acid acetoxymethyl ester also inhibited cytokine *induced* [ICAM-1] expression . Positive_regulation ICAM1 TNF 10860946 704992 These data suggest that TNFR1 , through a TNF receptor associated factor 2-NF-kappaB signaling pathway , mediates *induced* expression of [ICAM-1] on ASM cells by involving a thapsigargin-sensitive signaling pathway . Positive_regulation ICAM1 TNF 10867614 706489 Furthermore , CEA , [ICAM-1] and CD44v6 were *increased* by plus calcitriol . Positive_regulation ICAM1 TNF 10868446 706520 and 3 ) the upregulation of SOD mRNA , with subsequent increase in the SOD production and local release of IL-1beta and , may *activate* [ICAM-1] expression and neutrophil infiltration , which appear to play an important role in the progression of I/R induced acute gastric erosions into chronic ulcers . Positive_regulation ICAM1 TNF 10892347 711287 *Induction* of VCAM-1 and [ICAM-1] surface expression by was dose-dependently reduced by pycnogenol . Positive_regulation ICAM1 TNF 10900176 712704 DPI also inhibited TNF and LPS induced VCAM-1 and ICAM-1 cell surface expression and , LPS , or IL-1 beta *induced* VCAM-1 and [ICAM-1] mRNA accumulation . Positive_regulation ICAM1 TNF 10908988 713804 The findings indicate that stimulation of [ICAM-1] by endotoxin is *mediated* , at least in part , by and IL-1 beta . Positive_regulation ICAM1 TNF 10918504 717001 Therefore , we examined the effect of NFkappaB decoy ODN transfection on *induced* endogenous interleukin (IL)-1alpha , IL-1beta , IL-6 , [ICAM-1] and VCAM-1 gene expression as assessed by RT-PCR and Northern blotting . Positive_regulation ICAM1 TNF 10975537 729352 High-dose MP reduced the *induced* [ICAM-1] and VCAM-1 expression . Positive_regulation ICAM1 TNF 10976991 729645 In the present study , we investigated effects of a synthetic glucocorticoid , dexamethasone ( Dex ) , on *dependent* activation of NF-kappaB and expression of the [ICAM-1] gene . Positive_regulation ICAM1 TNF 10996391 733873 Early production of after liver injury could *induce* an increased [ICAM-1-expression] and a decreased PECAM-1 expression , which might be essential for the transmigration of inflammatory cells into the parenchyma . Positive_regulation ICAM1 TNF 10996603 733891 In addition , they suppressed interleukin-1beta- or *induced* expression of E-selectin , vascular cell adhesion molecule-1 ( VCAM-1 ) and [intercellular adhesion molecule-1] ( ICAM-1 ) on the surface of the endothelial cells . Positive_regulation ICAM1 TNF 11006011 735174 and LTalpha1beta2 both *increased* the expression of VCAM-1 and [ICAM-1] on FDC-LC . Positive_regulation ICAM1 TNF 11032726 740285 We have found that E-73 , an acetoxyl analogue of cycloheximide , specifically blocks *induced* [ICAM-1] expression even at concentrations unable to affect protein synthesis . Positive_regulation ICAM1 TNF 11034993 786069 Although the TNFalpha response element is sufficient for *induction* of the [ICAM-1] promoter , LMP1 also required the cooperation of additional upstream sequences for optimal induction . Positive_regulation ICAM1 TNF 11036165 741139 Interferon beta-1a downregulates *induced* [intercellular adhesion molecule 1] expression on brain microvascular endothelial cells through a tyrosine kinase dependent pathway . Positive_regulation ICAM1 TNF 11036165 741140 When an ineffective dose of IFbeta-1a ( 100 U/ml ) was challenged with ineffective doses of either genestein ( 10 microgram/ml ) or staurosporin ( 0.1 nM ) , the combination IFbeta-1a-genestein significantly reduced *induced* [ICAM1] expression whereas IFbeta-1a-staurosporin did not . Positive_regulation ICAM1 TNF 11069617 747841 It effectively inhibited *induced* expression of [intercellular adhesion molecule-1] in human skin transplanted on severe compromised immunodeficient mice . Positive_regulation ICAM1 TNF 11096064 802160 We found that OFF inhibits NF-kappaB-DNA binding activities , especially TNF-alpha induced p50-p65 heterodimer NF-kappaB activation and *induced* [intercellular adhesion molecule-1] mRNA expression . Positive_regulation ICAM1 TNF 11096064 802163 The inhibitory effects of OFF on both *induced* NF-kappaB activation and [intercellular adhesion molecule-1] mRNA expression were shear stress dependent and also increased with OFF exposure duration , indicating that OFF has potent effects on mechanotransduction pathways . Positive_regulation ICAM1 TNF 11118915 758120 The effects of Cryptococcus neoformans secreted antigens on *induced* [intercellular adhesion molecule-1] expression on human lung epithelial cells . Positive_regulation ICAM1 TNF 11118915 758122 We report here that SAs from encapsulated and acapsular strains of C. neoformans caused significant reductions in *induced* [intercellular adhesion molecule-1] ( ICAM-1 ) expression on A549 lung epithelial cells in culture . Positive_regulation ICAM1 TNF 11122238 758523 On the other hand , late-phase [ICAM-1] down-regulation was not *prevented* by the addition of exogenous . Positive_regulation ICAM1 TNF 11128721 759941 In contrast , in malignant thyrocyte cultures , ECM significantly attenuated IFNgamma- and mediated *enhancement* of [ICAM-1] expression . Positive_regulation ICAM1 TNF 11154420 762898 Prostaglandins E2 and I2 downregulate alpha *induced* [intercellular adhesion molecule-1] expression in human oral gingival epithelial cells . Positive_regulation ICAM1 TNF 11154420 762900 potently *induced* [ICAM-1] expression in a dose- and time dependent fashion . Positive_regulation ICAM1 TNF 11154420 762901 Next , of the four subtypes of PGE2 receptors ( EP1 , EP2 , EP3 and EP4 ) , we examined which subtype ( s ) mediated inhibition of *induced* [ICAM-1] expression by PGE2 . Positive_regulation ICAM1 TNF 11154420 762902 11-deoxy-PGE2 , an EP2/EP4 agonist , significantly suppressed *induced* [ICAM-1] expression , whereas butaprost , an EP2 agonist , sulprostone , an EP1/EP3 agonist , and ONO-AP-324 , an EP3 agonist , caused no effect on it . Positive_regulation ICAM1 TNF 11154420 762913 Dibutyryl cAMP , a cAMP analogue , and forskolin , a direct activator of adenylate cyclase , significantly inhibited *induced* [ICAM-1] expression in oral gingival epithelial cells . Positive_regulation ICAM1 TNF 11157054 780710 Initial comparisons indicated that alpha *induction* of epithelial [intercellular adhesion molecule 1] required sequential induction of interleukin (IL)-12 ( p70 ) and interferon gamma , and unexpectedly localized IL-12 production to airway epithelial cells . Positive_regulation ICAM1 TNF 11162639 782336 Since hyperhomocysteinemia appears to be an independent risk factor for the development of atherosclerosis , in this study we investigated the effect of homocysteine on basal and *induced* expression of [intercellular adhesion molecule-1] ( ICAM-1 ) , vascular cell-adhesion molecule-1 ( VCAM-1 ) , and endothelial leukocyte adhesion molecule-1 ( E-selectin ) on human umbilical-vein endothelial cells . Positive_regulation ICAM1 TNF 11162639 782339 Incubation of endothelial cells with homocysteine resulted in dose dependent reduction in *induced* ( 5 ng/ml ) expression of VCAM-1 , E-selectin , and [ICAM-1] ( the latter less pronounced ) . Positive_regulation ICAM1 TNF 11198351 779649 Stimulation of control cells with *resulted* in reactive oxygen species ( ROS ) generation and activation of NF-kappaB binding to the ICAM-1 promoter and [ICAM-1] transcription . Positive_regulation ICAM1 TNF 11216853 785875 We evaluated the effects of grape seed proanthocyanidin extract ( GSPE ) on the expression of *induced* [ICAM-1] and VCAM-1 expression in primary human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation ICAM1 TNF 11216853 785877 GSPE at low concentrations ( 1-5 micrograms/ml ) , down-regulated *induced* VCAM-1 expression but not [ICAM-1] expression in HUVEC . Positive_regulation ICAM1 TNF 11225735 580984 NF-kappaB activation was greatly potentiated by increased 15-LO activity in the stably transduced cells , and both VCAM-1 and [ICAM-1] were significantly induced in these cells in *response* to and phorbol 12-myristate 13-acetate ( PMA ) stimulation , as studied by flow cytometry . Positive_regulation ICAM1 TNF 11273998 797550 For dose finding , the effect of aspirin ( 1 , 2 , 5 , and 10 mmol/L ) on the *induced* upregulation of [intercellular adhesion molecule-1] was analyzed in monocultures of human coronary endothelial cells ( HCAEC ) and the SMCs of the human coronary media ( HCMSMC ) . Positive_regulation ICAM1 TNF 11300880 803296 A thieno [ 2,3-d ] pyrimidine , A-155918 , was identified from a whole-cell high-throughput assay for compounds which inhibited the *induced* expression of E-selectin , [ICAM-1] , or VCAM-1 on human vascular endothelial cells . Positive_regulation ICAM1 TNF 11322336 291247 Binding experiments using both 51Cr labelled lymphocytes , for quantitative analysis , and scanning electron microscopy demonstrated that increased expression of [ICAM-1] and VCAM-1 on the surface of Sertoli cells , *induced* by , determines an augmented adhesion between the two cell types . Positive_regulation ICAM1 TNF 11340302 812464 Of importance , NFkappaB , but not scrambled decoy ODN , significantly attenuated the increase in RNA and protein levels of IL-1alpha , IL-1beta , IL-6 , [ICAM-1] and VCAM-1 *induced* by assessed by RT-PCR . Positive_regulation ICAM1 TNF 11401521 824515 In this study , we examine the molecular mechanism of troglitazone on the basal and *induced* [ICAM-1] gene expression . Positive_regulation ICAM1 TNF 11401521 824516 In human vascular endothelial cells ( ECV304 cells ) , troglitazone inhibited *induced* [ICAM-1] gene expression by suppressing NF-kappaB/DNA binding activity , NF-kappaB transcriptional responses , c-Fos mRNA and protein levels via a ligand dependent , PPARgamma activated manner . Positive_regulation ICAM1 TNF 11403206 824945 At 4 h [ICAM-1] and E-selectin , but not VACM-1 , were *stimulated* by both IL-1beta and . Positive_regulation ICAM1 TNF 11403206 824952 [ICAM-1] , VCAM-1 , and E-selectin expression were all *stimulated* by both IL-1beta and in the 24 h assays . Positive_regulation ICAM1 TNF 11435466 832524 However , the cytotoxic responses to daunorubicin and exogenous ceramide remain unaltered , as do the *induced* p42/p44 MAPK activation and [CD54] expression . Positive_regulation ICAM1 TNF 11435740 832692 stimulation *resulted* in a 4-fold increase in [ICAM-1] and VCAM-1 expression . Positive_regulation ICAM1 TNF 11435740 832693 The *induced* increase in [ICAM-1] expression was reduced by 1,25-vitamin D ( 3 ) dose dependently ( 10 ( -7 ) M vs. solvent : -30 % ; 10 ( -9 ) M : -18 % ; 10 ( -11 ) M : -17 % ) . 25 ( OH ) -vitamin D ( 3 ) had no effect . Positive_regulation ICAM1 TNF 11435740 832694 The *induced* increase in soluble [ICAM] in culture supernatants was unchanged by 1,25-vitamin D ( 3 ) . Positive_regulation ICAM1 TNF 11436044 832710 Aprotinin inhibited *stimulated* expression of [intercellular adhesion molecule-1] ( P =.019 at 1600 kIU/mL ) and vascular cell adhesion molecule-1 ( P =.003 at 1600 kIU/mL ) but not E-selectin . Positive_regulation ICAM1 TNF 11449988 765990 Adrenergic mediation of *stimulated* [ICAM-1] expression on human brain microvascular endothelial cells . Positive_regulation ICAM1 TNF 11449988 765991 This report demonstrates that adrenergic agents attenuate the *induced* expression of [intercellular adhesion molecule-1] ( ICAM-1 ) on cerebral microvascular endothelial cells ( HBMEC ) derived from human brains . Positive_regulation ICAM1 TNF 11449988 765992 These data show that the beta 2-adrenergic receptor/cAMP pathway may be partly involved in *stimulated* [ICAM-1] expression and indicate the possible involvement of adrenergic mediation of capillary function including BBB integrity . Positive_regulation ICAM1 TNF 11450703 836645 Furthermore , the inhibitors completely prevented the *dependent* induction of MMP-1 , MMP-3 , [ICAM-1] , and COX-2 mRNAs . Positive_regulation ICAM1 TNF 11483407 844304 Tyrosine kinase inhibitors ( genistein or tyrphostin 23 ) or phosphatidylcholine-specific phospholipase C ( PC-PLC ) inhibitor ( D 609 ) attenuated *induced* [ICAM-1] expression . Positive_regulation ICAM1 TNF 11483407 844306 However , *induced* [ICAM-1] expression was not affected by either MEK inhibitor , PD 98059 , or p38 inhibitor , SB 203580 . Positive_regulation ICAM1 TNF 11483407 844317 NF-kappaB DNA-protein binding and [ICAM-1] promoter activity were *enhanced* by and these effects were inhibited by D 609 , calphostin C , or tyrphostin 23 , but not by PD 98059 or SB 203580 . Positive_regulation ICAM1 TNF 11490158 845651 These results suggest that increased expression of ICAM-1 by endothelial cells might be involved in the pathogenesis of acute KD , and that might *induce* [ICAM-1] expression . Positive_regulation ICAM1 TNF 11494147 846189 Importantly , the proteasome inhibitor PS-341 abrogated induced NF-kappaB activation , *induction* of [ICAM-1] or VCAM-1 , and increased adhesion of MM cells to BMSCs . Positive_regulation ICAM1 TNF 11510784 848800 An upregulation of [intercellular adhesion molecule-1] ( ICAM-1 ) expression was *induced* by ( p=0.0004 ) , but not by interleukin-4 (IL-4) ( p > 0.05 ) , while none of the two cytokines were able to increase hyaluronic-cellular adhesion molecule ( H-CAM ) expression by lung fibroblasts ( p > 0.05 ) . Positive_regulation ICAM1 TNF 11562425 862787 Pretreatment of ASM cells with SB203580 , a p38 MAPK inhibitor , slightly enhanced *induced* [ICAM-1] expression in a dose dependent manner but partially inhibited secretion of RANTES and IL-6 . Positive_regulation ICAM1 TNF 11570673 864286 [ICAM-1] expression on silica exposed mouse macrophages is *enhanced* by reactive oxygen species ( ROS ) and and appears to be regulated through specific sequence elements within the ICAM-1 promoter . Positive_regulation ICAM1 TNF 11602283 896063 Concentrations ( 1-100 microM ) of hamamelitannin that inhibited the TNF mediated cell death and DNA fragmentation , however , failed to inhibit the *induced* [ICAM-1] expression and EAhy926 cell adhesiveness to U937 cells . Positive_regulation ICAM1 TNF 11678903 873732 The expression of [ICAM-1] was significantly *increased* by interferon gamma (INF-gamma) or stimulation . Positive_regulation ICAM1 TNF 11729200 904356 Induction of neutropenia using anti-PMN serum prevented the initial *induced* NF-kappaB activation and [ICAM-1] expression in WT mice , indicating the involvement of PMN NAD(P)H oxidase in signaling these responses . Positive_regulation ICAM1 TNF 11729200 904359 Thus , oxidant signaling by the PMN NAD(P)H oxidase complex is an important determinant of *induced* NF-kappaB activation and [ICAM-1] expression in endothelial cells . Positive_regulation ICAM1 TNF 11730187 884903 To investigate the effect of olopatadine on the *mediated* mast cell upregulation of [ICAM-1] expression on conjunctival epithelial cells . Positive_regulation ICAM1 TNF 11763385 887888 Moreover , *induced* expression of [CD54] by cells in the medium , but not by those retained in the sheets , whereas human SCF induced , dose dependently , expression of CD54 by cells in the sheets , but not from those in the medium . Positive_regulation ICAM1 TNF 11772527 899345 Both vitamin E and vitamin C had no effect on ICAM-1 expression at the doses used , but ALA reduced the *stimulated* [ICAM-1] expression in a dose dependent manner , to levels observed in unstimulated cells . Positive_regulation ICAM1 TNF 11816800 887981 Then , we describe and study these different parameters using practical examples comparing *induced* [ICAM-1] expression as an end point , on HBL melanoma and HUVEC . Positive_regulation ICAM1 TNF 11817671 892845 The present study shows that [ICAM-1] expression is significantly elevated on alveolar macrophages from patients with sarcoidosis in *response* to and interferon-gamma (INF-gamma) compared with healthy controls . Positive_regulation ICAM1 TNF 11837795 911523 Heat shocking endothelial cells resulted in heat shock protein ( HSP ) expression as measured by HSP-70 induction , and decreased *induced* [ICAM-1] expression in a manner that appeared to be transcriptionally mediated . Positive_regulation ICAM1 TNF 11837795 911526 Interestingly , exposing respiratory epithelial cells to heat shock , which results in NF-kappaB inhibition , did not affect *induced* [ICAM-1] expression . Positive_regulation ICAM1 TNF 11872748 936937 *induced* [intracellular adhesion molecule (ICAM)-1] expression on both RPMI8226 and MM.1S cells is also inhibited by PS-1145 . Positive_regulation ICAM1 TNF 11886496 894179 Using human umbilical vein endothelial cells , dimethylfumarate almost completely inhibited *induced* CD62E , but not [CD54] expression at concentrations < or = 70 microM , mimicking the situation in vivo . Positive_regulation ICAM1 TNF 11901299 921932 Adhesion assays , ELISA , and flow cytometric analysis revealed that pretreatment with enoxaparin , at a relevant plasma concentration ( 16 microg/ml ) , acts upon activation of VEC by inhibition of lipopolysaccharide induced E-selectin expression and *stimulated* [ICAM-1] expression , thus reducing monocyte adhesion to VEC . Positive_regulation ICAM1 TNF 11926234 894533 Effects of dental resins on *induced* [ICAM-1] expression in endothelial cells . Positive_regulation ICAM1 TNF 11927644 927104 By contrast , this drug had only a mild effect on endothelial cells and a partial inhibition on the *induction* of [ICAM-1] expression by . Positive_regulation ICAM1 TNF 11954826 930703 Hyperoxia alone did not activate the intercellular adhesion molecule-1 ( ICAM-1 ) promoter , but augmented *mediated* activation of the [ICAM-1] promoter . Positive_regulation ICAM1 TNF 11971210 933617 UVB also significantly augmented [ICAM-1] *induction* by IL-1alpha and . Positive_regulation ICAM1 TNF 12013189 941617 When second passage cells were used , the expression of the adhesion molecules [ICAM-1] and VCAM-1 was markedly *increased* on all surfaces but not with . Positive_regulation ICAM1 TNF 12037401 949216 *induced* an upregulation of [ICAM-1] expression ( p < 0.05 ) , which was not seen in fibroblasts cultured in the presence of IL-4 or bFGF . Positive_regulation ICAM1 TNF 12037401 949225 Both bFGF induced fibroblast proliferation and *induced* [ICAM-1] expression were significantly reduced by fluticasone , starting at the dose of 1 and 10 nM , respectively ( p < 0.05 ) . Positive_regulation ICAM1 TNF 12067408 955032 CD34 expression was gradually lost , so that by day 9 , the majority of the cells were CD34 ( - ) /CMRF-44 ( + ) . GM-CSF and also *induced* CD40 expression , and up-regulation of [CD54] and MHC class II on CD34 ( + ) cells ; Positive_regulation ICAM1 TNF 12087872 959463 Neither testosterone nor 17 beta-estradiol affected the expression of [ICAM-1] *induced* by . Positive_regulation ICAM1 TNF 12111363 963493 *regulates* the expression of [ICAM-1] predominantly through TNF receptor 1 after chronic constriction injury of mouse sciatic nerve . Positive_regulation ICAM1 TNF 12111363 963495 Our data support the hypothesis that *regulates* the expression of [ICAM-1] predominantly through TNFR1 . Positive_regulation ICAM1 TNF 12124212 965697 Because IL-18 is a proinflammatory cytokine known to mediate the production of and IL-1beta and to *induce* the expression of [intercellular adhesion molecule-1] ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) , we hypothesized that neutralization of IL-18 would attenuate lipopolysaccharide (LPS) induced cardiac dysfunction . Positive_regulation ICAM1 TNF 12208465 983776 Increased intracellular calcium transients by calmodulin antagonists differentially modulate *induced* E-selectin and [ICAM-1] expression . Positive_regulation ICAM1 TNF 12213456 985383 Hydroxy- and acetoxyxanthones showed potent inhibitory effects on NADPH catalysed lipid peroxidation and *induced* expression of [ICAM-1] on endothelial cells . Positive_regulation ICAM1 TNF 12230943 988352 Class II MHC , B7-1 , B7-2 , and [ICAM-1] levels in HKC cells were significantly *increased* by the costimulation of IFN-gamma and . Positive_regulation ICAM1 TNF 12231500 988674 *Upregulation* of [ICAM-1] by and redistribution of ICAM-1 induced by cross linking antibodies were similar in both cell types . Positive_regulation ICAM1 TNF 12237332 989181 *induced* endothelial VCAM-1 , [ICAM-1] , and E-selectin surface expression was inhibited dose dependently . Positive_regulation ICAM1 TNF 12379212 997088 A double-strand decoy DNA oligomer for NF-kappaB inhibits *induced* [ICAM-1] expression in sinusoidal endothelial cells . Positive_regulation ICAM1 TNF 12379212 997089 Here we report that the decoy technique effectively suppresses *induced* [ICAM-1] expression in SEC . Positive_regulation ICAM1 TNF 12384485 998802 Endothelial cell [ICAM-1] upregulation in *response* to is mediated in part by reactive oxygen species ( ROS ) generated by the endothelial membrane associated NADPH oxidase and occurs maximally after 4 h as the synthesis of new protein is required . Positive_regulation ICAM1 TNF 12420742 1013415 Monochloramine inhibits the expression of E-selectin and [intercellular adhesion molecule-1] *induced* by through the suppression of NF-kappaB activation in human endothelial cells . Positive_regulation ICAM1 TNF 12420742 1013417 We studied the effects of monochloramine ( NH2Cl ) , a physiological oxidant derived from activated neutrophils , on the *induced* expression of E-selectin and [intercellular adhesion molecule-1] ( ICAM-1 ) in human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation ICAM1 TNF 12420742 1013421 Without NH2Cl , *induced* marked expression of e-selectin and [ICAM-1] . Positive_regulation ICAM1 TNF 12420742 1013423 These observations indicated that NH2Cl inhibited *induced* expression of E-selectin and [ICAM-1] through the inhibition of NF-kappaB activation . Positive_regulation ICAM1 TNF 12458035 1021580 Spantide also reduced expression of [ICAM-1] *induced* by and IFN-gamma by 35 % and 30 % , respectively . Positive_regulation ICAM1 TNF 12488365 1033015 In HDMEC , alpha-MSH ( 10 ( -8 ) /10 ( -12 ) M ) profoundly reduced the mRNA and protein expression of E-selectin , vascular CAM (VCAM)-1 , and [intercellular CAM (ICAM)-1] *induced* by LPS or as determined by semiquantitative RT-PCR , ELISA , and fluorescence activated cell sorter analysis . Positive_regulation ICAM1 TNF 12526087 1028228 However , lovastatin does not reduce *induced* expression of [ICAM-1] . Positive_regulation ICAM1 TNF 12562387 1053789 By in vitro bioassay , BP inhibited the ability of IFN-gamma but not IL-1beta or to *induce* [CD54] expression on epithelial cells . Positive_regulation ICAM1 TNF 12567686 767439 Excessive production of may *mediate* the expression of [ICAM-1] on brain EC and hence cause the development of CM . Positive_regulation ICAM1 TNF 12577469 1029624 Progesterone inhibited *stimulated* [CD54] and CD11b expression on the granulocytes and CD69 expression on lymphocytes by reducing partly the density of these molecules on the surface of cells , and in such way it partly blocked the proinflammatory activity of this cytokine . Positive_regulation ICAM1 TNF 12580918 1058389 A specific proteasome inhibitor N-cbz-Leu-Leu-leucinal ( MG-132 ) , but not a p38 MAPK inhibitor ( SB 203580 ) , was found to suppress the *induced* expression of [ICAM-1] on EoL-1 cells . Positive_regulation ICAM1 TNF 12587980 1029763 *induced* VCAM-1 and [ICAM-1] expression and Jurkat T cell binding . Positive_regulation ICAM1 TNF 12604246 1062604 Stimulation of the VECs with *led* to an increase in the DNA binding activity of the transcription factor , nuclear factor-kappa binding protein ( NF-kappaB ) and the induction of the adhesion molecule ( [ICAM)-1] . Positive_regulation ICAM1 TNF 12606638 1079731 In the present study , we demonstrate that adenoviral mediated expression of dominant negative N17Rac1 ( Ad.N17Rac1 ) suppresses *induced* vascular cell adhesion molecule-1 ( VCAM-1 ) , [intercellular adhesion molecule-1] ( ICAM-1 ) , and E-selectin gene expression in a dose dependent manner . Positive_regulation ICAM1 TNF 12606638 1079743 In contrast , Ad.N17Rac1 inhibited TNF-alpha induced NF-kappaB-driven HIV ( kappaB ) ( 4 ) -CAT and p288VCAM-Luc promoter activity , suggesting that N17Rac1 inhibits *induced* VCAM-1 , E-selectin , and [ICAM-1] through suppressing NF-kappaB mediated transactivation . Positive_regulation ICAM1 TNF 12606638 1079755 In addition , expression of superoxide dismutase by adenovirus suppressed *induced* VCAM-1 , E-selectin , and [ICAM-1] mRNA accumulation . Positive_regulation ICAM1 TNF 12615677 1065478 Moreover , simvastatin , atorvastatin , and cerivastatin were found to downregulate *induced* expression of [CD54] and CD18/CD11a in isolated PBMCs obtained from normal donors as well as TNF-alpha dependent expression of these CAMs in cultured human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation ICAM1 TNF 12633744 1068267 Treatment of HAEC with DFO ( 0.01-0.1 mM ) or NC ( 0.1 and 0.5 mM ) time- and dose-dependently inhibited *induced* protein expression of E-selectin , vascular cell adhesion molecule-1 ( VCAM-1 ) , and [intercellular adhesion molecule-1] ( ICAM-1 ) . Positive_regulation ICAM1 TNF 12645577 1069698 c-Src dependent tyrosine phosphorylation of IKKbeta is involved in *induced* [intercellular adhesion molecule-1] expression . Positive_regulation ICAM1 TNF 12645577 1069702 The signaling pathway involved in *induced* [intercellular adhesion molecule-1] ( ICAM-1 ) expression was further studied in human A549 epithelial cells . Positive_regulation ICAM1 TNF 12645577 1069706 Furthermore , the dominant negative c-Src ( KM ) mutant inhibited *induction* of [ICAM-1] promoter activity by or TPA . Positive_regulation ICAM1 TNF 12682486 1077808 Gabexate mesilate inhibited the *induced* increases in the endothelial expression of E-selectin and [intercellular adhesion molecule-1] by inhibiting the transcription . Positive_regulation ICAM1 TNF 12691701 1080390 In contrast , treatment *augmented* [ICAM-1] expression on the surface of vector-alone transfected HEp2 cells and not on the HEp2-IkappaB ( ( S32AS36A ) ) cells . Positive_regulation ICAM1 TNF 12714560 1093381 Stimulation of human pulmonary artery endothelial cells with *resulted* in phosphorylation of [ICAM-1] within 1 minute , a response that was sustained up to 15 minutes after TNF-alpha challenge . Positive_regulation ICAM1 TNF 12714560 1093383 As PKCzeta , an atypical PKC isoform abundantly expressed in endothelial cells , is implicated in signaling *induced* [ICAM-1] gene transcription , we determined the possibility that PKCzeta was involved in mediating endothelial adhesivity through ICAM-1 expression . Positive_regulation ICAM1 TNF 12714560 1093385 We observed that stimulation of endothelial cells *induced* PKCzeta activation and its association with [ICAM-1] . Positive_regulation ICAM1 TNF 12723939 1084234 Modulation of *induced* [ICAM-1] expression , NO and H2O2 production by alginate , allicin and ascorbic acid in human endothelial cells . Positive_regulation ICAM1 TNF 12723939 1084235 In addition , alginate , ascorbic acid and allicin were demonstrated to inhibit the *induced* expression of [ICAM-1] on the HUVECs in a dose dependent manner . Positive_regulation ICAM1 TNF 12738545 1087966 Stimulation of keratocytes with *resulted* in an increase in the abundance of ICAM-1 mRNA , the cell surface expression of [ICAM-1] protein , and enhanced adhesion of neutrophils to these cells . Positive_regulation ICAM1 TNF 1282723 207542 The *stimulated* [ICAM-1] expression is resistant however to downregulation of PKC with PMA . Positive_regulation ICAM1 TNF 12890192 1117235 It also inhibited *induced* [ICAM-1] and VCAM-1 expression by HUVEC at 10-6 mol L-1 . Positive_regulation ICAM1 TNF 12890192 1117236 RT-PCR analysis revealed that *induced* [ICAM-1] gene expression was strongly downregulated by MTX . Positive_regulation ICAM1 TNF 12890192 1117238 Low-dose MTX may act on psoriasis by suppressing the *induced* expression of [ICAM-1] and VCAM-1 by vascular endothelial cells . Positive_regulation ICAM1 TNF 12919942 1157688 activation of HEMEC *resulted* in upregulation of the cell adhesion molecules (CAM) [ICAM-1] , VCAM-1 , E-selectin , and mucosal addressin CAM-1 (MAdCAM-1) , increased IL-8 production , and enhanced leukocyte binding . Positive_regulation ICAM1 TNF 12941924 1133641 In this study , we found that MCMV infection of bone marrow derived macrophages inhibited *induced* [ICAM-1] surface expression and mRNA expression in infected cells via expression of immediate early and/or early viral genes . Positive_regulation ICAM1 TNF 1346267 179107 The *induced* expression of [ICAM-1] on HDMEC was blocked by co-incubation with a neutralizing antibody against TNF , but not with neutralizing antibodies against IL-1 alpha , IL-1 beta , or IL-6 . Positive_regulation ICAM1 TNF 1346267 179108 In addition , co-incubation of HDMEC with TNF and the retinoid compound acitretin , dexamethasone , or indomethacin did not abrogate the *induced* [ICAM-1] expression . Positive_regulation ICAM1 TNF 1346374 179112 IL-1 , IL-6 , and IFN-alpha , used alone or in combination , did not *induce* [ICAM-1] expression , neither did they inhibit the IFN-gamma induced expression of this adhesion molecule on HepG2 cells . Positive_regulation ICAM1 TNF 1347198 179206 We conclude from these data that although PMA induced ICAM-1 expression may be triggered through activation of protein kinase C , [ICAM-1] *induction* by IL-1 beta , , or LPS may involve distinct regulatory pathway ( s ) . Positive_regulation ICAM1 TNF 1347304 179211 In contrast , [ICAM-1] expression on two of the three cell lines ( KG1 and HL60 ) was *inducible* by to a much higher degree than by IFN-gamma , whereas the results with U937 were comparable with those obtained for normal monocytes . Positive_regulation ICAM1 TNF 1348968 185807 , interleukin 1 , and gamma-interferon also *caused* the release of soluble [ICAM-1] . Positive_regulation ICAM1 TNF 1349767 185992 At the same time IL-4 was unable to alter the *induced* [ICAM-1] up-regulation . Positive_regulation ICAM1 TNF 1349767 185993 Taken together we show in this paper that IL-4 decreases IFN-gamma but not induced *up-regulation* of [ICAM-1] expression on EA.hy 926 cells . Positive_regulation ICAM1 TNF 1350607 188048 Accordingly , UV light ( 0-100 J/m2 ) inhibited IFN gamma- as well as *induced* [ICAM-1] mRNA expression , if KC were cytokine stimulated immediately after irradiation . Positive_regulation ICAM1 TNF 1351055 188080 These results suggest that PMA acts through protein kinase C to up-regulate ICAM-1 expression primarily at a post-transcriptional level by stabilizing ICAM-1 mRNA , whereas transcriptionally *regulates* [ICAM-1] gene expression through an undefined , protein kinase C-independent pathway . Positive_regulation ICAM1 TNF 1352532 190363 alone *induced* only [ICAM-1] . Positive_regulation ICAM1 TNF 1357984 200314 Furthermore , *increased* the expression of the [intercellular adhesion molecule-1] and enhanced interferon-gamma induced HLA-DR expression in human glioblastoma cell line . Positive_regulation ICAM1 TNF 1357985 200315 *Induction* of [ICAM-1] by , IL-1 beta , and LPS in human endothelial cells after downregulation of PKC . Positive_regulation ICAM1 TNF 1357985 200318 The [intercellular adhesion molecule 1] ( ICAM-1 ) is *induced* on endothelial cells by , interleukin-1 beta (IL-1 beta) , and lipopolysaccharide (LPS) . Positive_regulation ICAM1 TNF 1358619 200376 As determined by immunocytochemistry and immunoprecipitation using a monoclonal anti-ICAM-1 antibody , interleukin-1-alpha (IL-1a) , and interferon-gamma (IFNg) strongly *enhanced* surface expression of [ICAM-1] in both GO- and normal OF . Positive_regulation ICAM1 TNF 1374096 186281 also *induces* [ICAM-1] in both of these neural cell lines . Positive_regulation ICAM1 TNF 1374588 186319 In contrast , dermal fibroblasts upregulated [intercellular adhesion molecule-1] ( ICAM-1 ) but not VCAM-1 expression in *response* to . Positive_regulation ICAM1 TNF 1380176 193164 *induced* expression of endothelial adhesion molecules , [ICAM-1] and VCAM-1 , is linked to protein kinase C activation . Positive_regulation ICAM1 TNF 1380176 193165 Phorbol myristate acetate , which is known to activate PKC , was able to mimic *induced* up-regulation of [ICAM-1] and partly also VCAM-1 expression . Positive_regulation ICAM1 TNF 1380176 193166 Similarly a PKC inhibitor , H7 , but not another kinase inhibitor , HA1004 , inhibited *induced* enhancement of [ICAM-1] expression at both the mRNA and the protein level . Positive_regulation ICAM1 TNF 1381227 196039 The present study aimed to see whether *induction* of ELAM-1 and [ICAM-1] on human umbilical vein endothelial cells ( HUVECs ) involved novel TNF-receptor interactions . Positive_regulation ICAM1 TNF 1381227 196043 It is concluded that ( a ) the same part of the TNF molecule interacts with TNF-receptors on HUVECs and other cell types and ( b ) *induction* of ELAM-1 and [ICAM-1] on HUVECs is mediated via the well characterized 55 kDa TNF receptor . Positive_regulation ICAM1 TNF 1382639 198289 Exposure of HUVEC to perflubron did not alter the up-regulation of [ICAM] or ELAM in *response* to IL-1 or ( n = 20 ) . Positive_regulation ICAM1 TNF 14519761 1174279 Secreted IFNbeta acted as a negative regulator of TNFalpha induced interleukin-6 expression , while IFNbeta augmented TNFalpha induced RANTES ( regulated on activation normal T cell expressed and secreted ) secretion but had little effect on *induced* [intercellular adhesion molecule-1] expression . Positive_regulation ICAM1 TNF 14561851 1165100 In cultured human umbilical vein endothelial cells ( HUVECs ) , and lipopolysaccharide *increased* phosphorylation of p38 MAPK ( P-p38 MAPK ) and increased [ICAM-1] expression . Positive_regulation ICAM1 TNF 14565715 1154954 HPVEC express E-selectin , [ICAM-1] , and VCAM-1 in *response* to the inflammatory cytokine similarly to other types of cultured human endothelial cells . Positive_regulation ICAM1 TNF 14568945 1155369 *dependent* [ICAM-1-] and VCAM-1 mediated inflammatory responses are delayed in neonatal mice infected with Pneumocystis carinii . Positive_regulation ICAM1 TNF 14572152 1155744 Defect of tumour necrosis factor-alpha (TNF-alpha) production and *induced* [ICAM-1-expression] in BRCA1 mutations carriers . Positive_regulation ICAM1 TNF 14572152 1155746 We conclude that the presence of germline mutations of BRCA1 was associated with a selective deficiency in spontaneous and LPS induced production of TNF-alpha and of *induced* [ICAM-1] expression on peripheral blood monocytes . Positive_regulation ICAM1 TNF 14572618 1155842 In contrast , either the proteasome inhibitor carbobenzoxy-L-leucy-L-leucy-L-leucinal ( MG 132 ) or the IkappaBalpha inhibitor BAY 11-7082 ablated *induced* [ICAM-1] gene expression and MG132 inhibited TNFalpha induced NFkappaB complexes . Positive_regulation ICAM1 TNF 14572618 1155846 Because interference with either signaling pathway abrogates *induced* [ICAM-1] expression , activation of both complexes seems to be involved in this response to TNFalpha , but this activation occurs via different intracellular pathways . Positive_regulation ICAM1 TNF 14583404 1158918 In *response* to , isolated mouse brain endothelial cells ( MBEC ) express vascular cell adhesion molecule-1 ( VCAM-1 ) and [intercellular adhesion molecule-1] ( ICAM-1 ) . Positive_regulation ICAM1 TNF 14615388 1188005 Shear stress increased the *induced* expression of [intercellular adhesion molecule-1] ( ICAM-1 ) at both mRNA and surface protein levels , but decreased the TNF-alpha induced expression of vascular adhesion molecule-1 (VCAM-1) and E-selectin . Positive_regulation ICAM1 TNF 14615388 1188006 After 24-hour preshearing followed by 1 hour of static incubation , the effect of preshearing on *induced* [ICAM-1] mRNA expression vanished . Positive_regulation ICAM1 TNF 14615388 1188010 Our findings suggest that shear stress plays differential roles in modulating the *induced* expressions of [ICAM-1] versus VCAM-1 and E-selectin genes in ECs . Positive_regulation ICAM1 TNF 14632660 1170690 Induction of [ICAM-1] by IL-18 was *dependent* on endogenous , and IL-12 had an additive effect on that of IL-18 . Positive_regulation ICAM1 TNF 14682382 1179316 [ICAM-1] , expressed on PC-3 and DU 145 cells , was *enhanced* by and IL-10 . Positive_regulation ICAM1 TNF 14720501 1197837 Specific inhibitors for JNK and NF-kappaB also inhibited *induced* [ICAM-1] and VCAM-1 expressions in HUVEC . Positive_regulation ICAM1 TNF 14741380 1203262 RORalpha1 and RORalpha4 suppress *induced* VCAM-1 and [ICAM-1] expression in human endothelial cells . Positive_regulation ICAM1 TNF 14741380 1203264 Adenovirus mediated overexpression of RORalpha1 and RORalpha4 suppressed *induced* expression of vascular cell adhesion molecule-1 ( VCAM-1 ) and intracellular adhesion molecule-1 ( [ICAM-1] ) in human umbilical vein endothelial cells . Positive_regulation ICAM1 TNF 14769217 1207904 ISA inhibited *stimulated* PMN-HUVEC adhesion and expression of [ICAM-1] . Positive_regulation ICAM1 TNF 14984317 1214673 The effect of high glucose concentration on *induced* expression of ELAM-1 , VCAM-1 and [ICAM-1] was negligible , if at all . Positive_regulation ICAM1 TNF 14991079 1182876 Here we show that BMS-345541 , a highly selective inhibitor of IkappaB kinase , inhibited the *induced* expression of both [ICAM-1] and VCAM-1 in human umbilical vein endothelial cells at the same concentration range as cytokine expression is inhibited in monocytic cells ( IC ( 50 ) congruent with 5 microM ) . Positive_regulation ICAM1 TNF 15016640 1243406 Early cell cycle arrest of aortic smooth muscle cells was found to inhibit the *induced* upregulation of vascular cell adhesion molecule-1 and [intercellular adhesion molecule-1] , important markers of vascular cell activation in diseases such as atherosclerosis . Positive_regulation ICAM1 TNF 15068815 1232314 Pretreatment of HUVEC with butyrate inhibited *induced* expression of vascular cell adhesion molecule-1 ( VCAM-1 ) and intracellular cell adhesion molecule-1 ( [ICAM-1] ) in a time and concentration dependent manner . Positive_regulation ICAM1 TNF 15113938 1241390 significantly *induced* HUVEC protein expression of VCAM-1 , [ICAM-1] , and E-selectin with increasing mRNA levels . Positive_regulation ICAM1 TNF 15180961 1273668 *stimulated* production of [ICAM-1] , which was however not associated with induction of GSH . Positive_regulation ICAM1 TNF 15191888 1295248 SphK1 siRNA also inhibited *induced* cell surface expression of VCAM-1 , but not [ICAM-1] , protein . Positive_regulation ICAM1 TNF 15199628 1260701 When HUVEC was treated by AP plus IL-1 , the IL-1 induced PMN adhesion with HUVEC could be strengthened , and the expression of HUVEC superficial adhesive factor [ICAM-1] *induced* by IL-1 and was strengthened also , but when PMN treated with AP , it showed no effect on the expression of adhesive factor CD18 . Positive_regulation ICAM1 TNF 15217903 1295635 In this study , CYL-19 s and CYL-26z , two synthetic alpha-methylene-gamma-butyrolactone derivatives , were shown to inhibit the *induced* [intercellular adhesion molecule-1] ( ICAM-1 ) expression in human A549 alveolar epithelial cells and the adhesion of U937 cells to these cells . Positive_regulation ICAM1 TNF 15217903 1295636 RT-PCR analysis also demonstrated their inhibitory effects on *induced* [ICAM-1] mRNA expression . Positive_regulation ICAM1 TNF 15217903 1295637 *induced* [ICAM-1] and NF-kappaB dependent promoter activities were attenuated by CYL-19 s and CYL-26z . Positive_regulation ICAM1 TNF 15266023 1275867 8-Bromo-cADPr , however , did not affect *induced* cell surface expression of [intercellular adhesion molecule-1] . Positive_regulation ICAM1 TNF 15275879 1276745 and IL-1beta *increased* [ICAM-1] expression in both control and Crohn 's disease . Positive_regulation ICAM1 TNF 15322261 1286982 Flavonoids inhibit *induced* up-regulation of [intercellular adhesion molecule-1] ( ICAM-1 ) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB : structure-activity relationships . Positive_regulation ICAM1 TNF 15322261 1286983 We investigated the effects of flavonols ( kaempferol , quercetin , and myricetin ) and flavones ( flavone , chrysin , apigenin , luteolin , baicalein , and baicalin ) on the *stimulated* [ICAM-1] expression . Positive_regulation ICAM1 TNF 15322261 1286989 *induced* [ICAM-1] promoter activity was attenuated using an activator protein-1 (AP-1) site deletion mutant , indicating the involvement of AP-1 in ICAM-1 expression . Positive_regulation ICAM1 TNF 15452110 1341987 In contrast , *induced* p42/p44 MAPK activation and [CD54] expression remained unaltered . Positive_regulation ICAM1 TNF 15479458 1319776 We first evaluated by flow cytometry the pTNFR1Ig capacity to prevent *induced* expression of SLAI , SLAII , VCAM-1 , [ICAM-1] and E-selectin on the cell surface of porcine aortic endothelial cells ( PAEC ) . Positive_regulation ICAM1 TNF 15489375 1359455 In the present study , we show that pretreatment with rottlerin , a specific inhibitor of protein kinase C (PKC)-delta , or transient transfection with antisense PKCdelta oligonucleotides significantly inhibits *induced* expression of VCAM-1 , but not of [intercellular adhesion molecule (ICAM)-1] in human lung epithelium A549 cells . Positive_regulation ICAM1 TNF 15554267 1338742 Vitamin C blocks *induced* NF-kappaB activation and [ICAM-1] expression in human neuroblastoma cells . Positive_regulation ICAM1 TNF 15554267 1338745 In this study , the effect of vitamin C on the [ICAM-1] expression *induced* by in a human neuroblastoma cell line , SK-N-SH was investigated . Positive_regulation ICAM1 TNF 15554267 1338749 Taken together , these results suggest that vitamin C downregulates *induced* [ICAM-1] expression via the inhibition of NF-kappaB activation . Positive_regulation ICAM1 TNF 15557193 1340491 In parallel studies we observed that inhibition of the RhoA/ROCK pathway by the same pharmacological and genetic approaches failed to inhibit *induced* NF-kappaB activation and [ICAM-1] expression . Positive_regulation ICAM1 TNF 15574511 1355710 This hypothesis was examined further by *stimulation* of PTC [ICAM] expression by . Positive_regulation ICAM1 TNF 15574511 1355719 Although stimulation of PTC by BMP-7 alone decreased cell surface ICAM expression , it did not affect *induced* [ICAM] expression . Positive_regulation ICAM1 TNF 15626898 1349304 *induced* [ICAM-1] and VCAM-1 expression in primary cultures of human umbilical vein endothelial cells was reduced by co-incubation with CsA . Positive_regulation ICAM1 TNF 15630284 1349426 Furthermore , quercetin-3-glucuronide showed no suppressive effect on *induced* cell expression of [intercellular adhesion molecule-1] ( ICAM-1 ) on HAECs . Positive_regulation ICAM1 TNF 15650392 1364027 , but not H2O2 , *induced* [ICAM-1] in A549 cells , which was attenuated by a proteasome inhibitor , but not by the p38 MAPK inhibitor SB203580 . Positive_regulation ICAM1 TNF 15662020 1382006 We demonstrate that 15d-PGJ2 induced RORalpha1 and RORalpha4 expression and inhibited *induced* vascular cell adhesion molecule-1 ( VCAM-1 ) and [intercellular adhesion molecule-1] ( ICAM-1 ) expression in human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation ICAM1 TNF 15662020 1382008 Adenovirus mediated overexpression of RORalpha1 inhibited *induced* VCAM-1 and [ICAM-1] expression , and overexpression of a mutant form of RORalpha1 ( RORalpha1Delta ) , which inhibited transcriptional activity of RORalpha1 and RORalpha4 , attenuated its inhibition . Positive_regulation ICAM1 TNF 15662020 1382010 Furthermore , we found that RORalpha1Delta attenuated the inhibitory actions of 15d-PGJ2 on *induced* VCAM-1 and [ICAM-1] expression . Positive_regulation ICAM1 TNF 15665118 1395336 Binding of monocytes to *activated* human endothelial cells as well as to VCAM-1 or [ICAM-1] also resulted in an increase of MT1-MMP expression . Positive_regulation ICAM1 TNF 15671209 1366094 Phloretin prevented *stimulated* upregulation of VCAM-1 , [ICAM-1] , and E-selectin expression in a concentration dependent manner . Positive_regulation ICAM1 TNF 15698778 1372336 We found that dihydroxy and diacetoxy derivatives of thiocoumarin were more potent in comparison to the corresponding coumarin derivatives in inhibiting *induced* expression of [ICAM-1] . Positive_regulation ICAM1 TNF 15720567 1376530 Although and IL-1beta , at concentrations a little higher than those in sera of periodontitis patients , *up-regulated* the expression of [intercellular adhesion molecule-1] and vascular cell adhesion molecule-1 , P. gingivalis antigens had only a slight stimulatory effect . Positive_regulation ICAM1 TNF 15743827 1379090 In coronary microvascular EC from p47phox-/- mice , *induced* NADPH oxidase activation , ERK1/2 activation , and cell surface [intercellular adhesion molecule 1] ( ICAM-1 ) expression were all inhibited . Positive_regulation ICAM1 TNF 15797891 1403773 In cultured tubular epithelial cells , rosiglitazone significantly decreased the expression of [ICAM-1] and VCAM-1 *induced* by or IL-1beta , inhibited the degradation of inhibitor kappaBalpha ( IkappaBalpha ) and blocked the activation of the p65 subunit of nuclear factor (NF)-kappaB . Positive_regulation ICAM1 TNF 15829418 1394328 MPA markedly inhibited *induced* [intercellular adhesion molecule-1] ( ICAM-1 ) mRNA and surface expression , suppressed TNFalpha induced neutrophils adhesion to endothelial cells , and reduced TNFalpha induced interleukin-6 (IL-6) secretion . Positive_regulation ICAM1 TNF 15864742 1401413 [ICAM-1] *induction* by and IL-6 is mediated by distinct pathways via Rac in endothelial cells . Positive_regulation ICAM1 TNF 15864742 1401419 The NFkappaB binding site in the ICAM-1 promoter region was crucial for *induced* [ICAM-1] expression but not for the induction by IL-6 . Positive_regulation ICAM1 TNF 15864742 1401425 Our data strongly indicated that [ICAM-1] gene *induction* by and IL-6 is mediated mainly via NFkappaB and Stat3 , respectively and Rac1 appears to play a central role in modulating cytokine induced ICAM-1 expression in ECs . Positive_regulation ICAM1 TNF 16155367 1467438 Pretreatment of ECs with DIM-C-pPhC ( 6 ) H ( 5 ) , DIM-C- pPhtBu , or 15d-PGJ2 decreased *induced* [intercellular adhesion molecule (ICAM)-1] expression in a concentration dependent manner . Positive_regulation ICAM1 TNF 16243536 1501697 Elevated HO-1 protein levels were associated with the inhibition of *induced* [intercellular adhesion molecule-1] ( ICAM-1 ) expression . Positive_regulation ICAM1 TNF 16249517 1471760 Stimulation of hRVECs with VEGF ( 165 ) , , or IL-1beta for 6 to 24 hours *caused* significant induction of [intracellular adhesion molecule (ICAM)-1] and vascular cell adhesion molecule (VCAM)-1 expression . Positive_regulation ICAM1 TNF 16259720 1477816 Ea.hy.926 human immortal HUVECs expressed [ICAM-1] in *response* to and PMA . Positive_regulation ICAM1 TNF 16313198 1486903 Both compounds 1 and 2 inhibited the *induced* expression of [ICAM-1] in a dose- and time dependent manner ; Positive_regulation ICAM1 TNF 16313198 1486904 The structure-activity studies indicate that the chain length of the alcohol moiety , substituents in the aromatic ring , and alpha , beta-double bond of the cinnamic acid ester have significant effects on the inhibition of *induced* expression of [ICAM-1] on endothelial cells . Positive_regulation ICAM1 TNF 16320108 1487741 [ICAM-1] expression in resting state , in the *presence* of or after the application of heparin or hyaluronan was determined by flow cytometry . Positive_regulation ICAM1 TNF 16328103 1511759 Inhibition of *induced* [intercellular adhesion molecule-1] expression in diabetic rats : role of insulin . Positive_regulation ICAM1 TNF 16328103 1511761 Insulin modulates *induced* [ICAM-1] expression on microvascular endothelium controlling , therefore , leukocyte adhesion and migration . Positive_regulation ICAM1 TNF 16354764 1519364 Further study demonstrated that TNF-alpha induced sphingosine kinase activity was inhibited by glabridin , and the inhibitory effect of glabridin on *induced* [ICAM-1] expression was reversed by addition of exogenous S1P . Positive_regulation ICAM1 TNF 16431966 1516123 Both and IFN-gamma *increased* the expression of [ICAM-1] at the mRNA and protein levels in a time- and dose dependent manner in ARPE-19 cells . Positive_regulation ICAM1 TNF 16432451 1516261 Sodium salicylate inhibits *induced* NF-kappaB activation , cell migration , invasion and [ICAM-1] expression in human melanoma cells . Positive_regulation ICAM1 TNF 16432451 1516264 The aim of this study was to investigate the effect of the non-steroidal anti-inflammatory agent sodium salicylate on *induced* activation of the transcription factor nuclear factor-kappaB (NF-kappaB) and upregulation of [intercellular adhesion molecule-1] ( ICAM-1 ) , and TNF-alpha stimulated cell migration and invasion through fibronectin . Positive_regulation ICAM1 TNF 16432451 1516267 Sodium salicylate inhibited TNF-alpha stimulated NF-kappaB activation in melanoma cells in a concentration dependent manner , and this was achieved with pre-incubation times as short as 15 min. *stimulated* [ICAM-1] expression in HBL cells was also downregulated by sodium salicylate , although in a manner inversely related to the concentration of this agent . Positive_regulation ICAM1 TNF 16432451 1516270 In conclusion , sodium salicylate effectively inhibited *induced* upregulation of NF-kappaB , [ICAM-1] expression , in-vitro migration and invasion in human melanoma cells , indicating that non-steroidal anti-inflammatory drugs may be a useful therapeutic approach to oppose inflammation induced melanoma invasion and metastasis in vivo . Positive_regulation ICAM1 TNF 16456224 1522390 This work showed that chemical stimulations with *induced* the [ICAM-1] expression of ECs differently depending largely on the film architecture employed . Positive_regulation ICAM1 TNF 16505157 1561609 Penetratin also inhibited *induced* [intercellular adhesion molecule-1] expression in human endothelial HMEC-1 cells . Positive_regulation ICAM1 TNF 16529752 1671841 In HUVEC , *induced* [ICAM-1] and VCAM-1 mRNA and surface expression . Positive_regulation ICAM1 TNF 16529752 1671842 Both statins caused an aggravation of *induced* [ICAM-1] and VCAM-1 mRNA expression which was dependent on RNA synthesis . Positive_regulation ICAM1 TNF 16529752 1671846 We conclude that cerivastatin and simvastatin reduce induced *up-regulation* of [ICAM-1] and VCAM-1 surface expression via increased protein shedding mediated by HMG-CoA reductase inhibition and subsequent isoprenoid depletion . Positive_regulation ICAM1 TNF 16549374 1549773 The noteworthy increase in protein levels of [intercellular adhesion molecule-1] ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) *induced* by was significantly decreased after incubation of the cells with 1,25 ( OH ) ( 2 ) D ( 3 ) , this effect not being seen on E-selectin expression . Positive_regulation ICAM1 TNF 16595000 1568603 ICAM-1 : Part I of the study investigates in cytoflow studies the effect of abciximab ( 0.0002 , 0.002 , 0.02 , 0.2 , 2.0 , and 20.0 microg/ml ) on *induced* expression of [intercellular adhesion molecule 1] ( ICAM-1 ) . Positive_regulation ICAM1 TNF 16604092 1562651 Additionally , *induced* secretion of soluble [intercellular adhesion molecule-1] and soluble vascular cell adhesion molecule-1 molecules was found to be attenuated by rosmarinic acid . Positive_regulation ICAM1 TNF 16641609 1553064 Surface expression of [ICAM-1] , VCAM-1 , and E-/P-selectin on MVEC was *up-regulated* by but unaffected by hypoxia/reoxygenation in the absence of TNF-alpha . Positive_regulation ICAM1 TNF 16647464 1553186 stimulation and TCR/CD28 co-stimulation significantly *increased* EC [ICAM-1/VCAM-1-expression] and LC CD25 surface expression , respectively . Positive_regulation ICAM1 TNF 1670943 151261 IFN-gamma or also *induced* [ICAM-1] on KC , but these KC failed to stimulate proliferation , suggesting that PMA induces additional signals from KC , which act in concert with ICAM-1 to promote proliferation . Positive_regulation ICAM1 TNF 16734619 1566222 and interferon (IFN)-gamma *enhanced* both [ICAM-1] and VCAM-1 expression on HGF . Positive_regulation ICAM1 TNF 16734619 1566235 Mitogen activated protein kinases (MAPK) inhibitors did not influence [ICAM-1] expression *induced* by . Positive_regulation ICAM1 TNF 1673988 155033 Both IFN-gamma and *induced* large increases in the [ICAM-1] expression on both cell lines and increased the susceptibility of the tumor cells to monocyte mediated killing . Positive_regulation ICAM1 TNF 1674973 157969 Among cytokines which were reported to be potent inducers of ICAM-1 on malignant melanoma cell lines , interferon (IFN)-gamma and *augmented* the expression of [ICAM-1] on ACHN cells whereas ICAM-1 and class I antigens on KRC/Y cells . Positive_regulation ICAM1 TNF 16803639 1579431 RGD targeted adenovirus delivered the dnIkappaB via alphavbeta3 to become functionally expressed , leading to complete abolishment of induced *up-regulation* of E-selectin , [ICAM-1] , VCAM-1 , IL-6 , IL-8 , VEGF-A and Tie-2 . Positive_regulation ICAM1 TNF 16872805 1672421 We therefore examined the effect of blocking the NFkappaB pathway on *stimulated* [ICAM-1] and VCAM-1 expression in primary cultures of human aortic smooth muscle cells using an adenoviral wild-type IkappaB alpha construct ( Ad.IkappaB alpha ) and dominant negative IKKalpha ( Ad.IKKalpha+/- ) and IKKbeta ( Ad.IKKbeta+/- ) constructs . Positive_regulation ICAM1 TNF 16872805 1672425 Ad . IkappaB alpha treatment was found to block NFkappaB DNA binding , and thereby completely prevent *stimulated* [ICAM-1] and VCAM-1 expression without influencing IKK activity . Positive_regulation ICAM1 TNF 16872805 1672441 Ad.IKKbeta+/- treatment completely inhibited TNFalpha stimulated IKK kinase activity , IkappaB alpha degradation and NFkappaB DNA binding in addition to completely blocking *stimulated* [ICAM-1] and VCAM-1 expression . Positive_regulation ICAM1 TNF 16872805 1672448 Our results demonstrate that TNFalpha stimulated ICAM-1 and VCAM-1 expression in human aortic smooth muscle cells is NFkappaB dependent , that IKKbeta is a suitable target for drug therapy and Ad.IKKbeta+/- an effective inhibitor of *stimulated* [ICAM-1] and VCAM-1 expression . Positive_regulation ICAM1 TNF 16892784 1597135 is *involved* in the up-regulation of [intercellular adhesion molecule 1] ( ICAM-1 ) . Positive_regulation ICAM1 TNF 16914593 1602144 and interleukin1 (IL1) ( 0.1 ng/ml ) *stimulated* [ICAM1] expression by eight- to ten-fold . Positive_regulation ICAM1 TNF 16914593 1602146 and IL1 *stimulate* [ICAM1] expression and GAG production , but have opposite effects on adipogenesis in OFs in vitro . Positive_regulation ICAM1 TNF 16916501 1672902 Semiquantitative RT-PCR analysis showed that reduced *induced* rise in [ICAM-1] mRNA expression significantly by 17 % ( p=0.001 ) . Positive_regulation ICAM1 TNF 16920299 1666193 Evidence presented in this report demonstrated that CML-1 inhibited the adhesive capacity of HUVEC and the mediated *induction* of E-selectin , [ICAM-1] and VCAM-1 in HUVEC by inhibiting the IkB/NF-kB signaling pathway at the level of IkB kinase , which may explain the ability of CML-1 to suppress inflammation and modulate the immune response . Positive_regulation ICAM1 TNF 16936090 1608910 Lipopolysaccharide (LPS) *induced* the release of the proinflammatory cytokine IL-6 and that of the chemokines G-CSF , MCP-1 , MIP-1beta , and IL-8 as well as surface expression of [ICAM-1] by corneal fibroblasts , whereas IL-1beta , , and GM-CSF were not detected in the culture supernatants of cells incubated with or without LPS . Positive_regulation ICAM1 TNF 1697308 139527 IFN-gamma plus cotreatment synergistically *increases* [ICAM-1] expression by 24 h of cotreatment , whereas IFN-gamma plus IL-1 beta cotreated EC show at most additive increases . Positive_regulation ICAM1 TNF 1701992 145093 We found that interleukin-1 beta (IL-1 beta) , , and interferon-gamma (IFN gamma) each *increased* the cell surface expression of [intercellular adhesion molecule 1] ( ICAM-1 ) on human synovial fibroblasts in a dose- and time dependent manner . Positive_regulation ICAM1 TNF 17068152 1693046 We observed that p75 was essential for *induced* E-selectin , vascular cell adhesion molecule 1 ( VCAM-1 ) , and [intercellular adhesion molecule 1] ( ICAM-1 ) expression . Positive_regulation ICAM1 TNF 17072061 1637714 NAC inhibited the beta *stimulated* [ICAM-1] expression and IL-8 release from both cell lines in a concentration dependent manner . Positive_regulation ICAM1 TNF 17085432 1675743 Role for neutral sphingomyelinase-2 in alpha *stimulated* expression of vascular cell adhesion molecule-1 (VCAM) and [intercellular adhesion molecule-1 (ICAM)] in lung epithelial cells : p38 MAPK is an upstream regulator of nSMase2 . Positive_regulation ICAM1 TNF 17145842 1653892 Thalidomide also suppressed *induced* [ICAM-1] expression through inhibition of nuclear factor-kappaB binding to the ICAM-1 promoter . Positive_regulation ICAM1 TNF 17161959 1694529 In addition , we investigated the molecular mechanisms underlying [ICAM-1] *induction* by , focusing on the activation of the mitogen activated protein kinases ( MAPKs ) and nuclear factor-kappaB (NF-kappaB) pathways . Positive_regulation ICAM1 TNF 1718801 169403 IFN-gamma and alone or in combination strongly *enhanced* this spontaneous expression of [ICAM-1] in a time- and/or dose dependent and additive manner but had no effect on LFA-3 . Positive_regulation ICAM1 TNF 17195014 1709353 *induced* [ICAM-1] in endothelial cells ( EC ) promotes leukocyte adhesion . Positive_regulation ICAM1 TNF 17209004 1732458 Venous and coronary artery flow both increased *induced* E-selectin and [ICAM-1] expression on HSVEC , but only coronary artery flow increased VCAM-1 expression . Positive_regulation ICAM1 TNF 17216105 1497164 *up-regulated* the expression of [ICAM-1] . Positive_regulation ICAM1 TNF 17237434 1690106 Of the two catalytic subunits of IKK ( IKKalpha and IKKbeta ) , low concentrations of NAC and mito-Q activated IKKalpha activity , thereby inhibiting the downstream NF-kappaB and [ICAM-1] *induction* by . Positive_regulation ICAM1 TNF 17238806 1664238 We used flow cytometry and either primary cultured human conjunctival cells or the Chang conjunctival cell model to determine the effects of glucosamine sulfate on the production of [ICAM-1] in *response* to , interferon (IFN)-gamma , interleukin (IL)-1beta , IL-6 , TNF-alpha plus IFN-gamma , or TNF-alpha plus IL-1beta . Positive_regulation ICAM1 TNF 17238806 1664241 Glucosamine sulfate effectively downregulated the production of [ICAM-1] *induced* by , IFN-gamma , IL-1beta , TNF-alpha plus IFN-gamma , or TNF-alpha plus IL-1beta . Positive_regulation ICAM1 TNF 17276892 1691898 The inhibitory effect of paeonol on ICAM-1 production might be mediated by inhibiting p38 , ERK and NF-kappaB signaling pathways , which are involved in *induced* [ICAM-1] production . Positive_regulation ICAM1 TNF 17292586 1725853 TNFR1 induced NF-kappaB , but not ERK , p38MAPK or JNK activation , mediates *induced* [ICAM-1] and VCAM-1 expression on endothelial cells . Positive_regulation ICAM1 TNF 17321745 1711801 Further , we found that incorporation of unsaturation in the alcohol moiety increases the potential of the compound for the inhibition of *induced* expression of [ICAM-1] and also for the inhibition of lipid peroxidation . Positive_regulation ICAM1 TNF 17327359 1740874 JWH133 also attenuates the *induced* [ICAM-1] and VCAM-1 expression in human liver sinusoidal endothelial cells ( HLSECs ) and the adhesion of human neutrophils to HLSECs in vitro . Positive_regulation ICAM1 TNF 17371935 1748316 Western blot and immunohistochemical analysis showed that *leads* to VCAM-1 and [ICAM-1] expressions that were inhibited by antiserum to human TNF receptor or by AP-1 inhibitor nobiletin . Positive_regulation ICAM1 TNF 17418379 1748712 [ICAM-1] was *induced* in human and guinea pig parasympathetic nerves by and IFN-gamma and was inhibited by dexamethasone and by an inhibitor of nuclear factor-kappaB (NF-kappaB) . Positive_regulation ICAM1 TNF 17434980 1772095 Additionally , we have explored the effects of anandamide on *induced* [ICAM-1] and VCAM-1 expression and monocyte-endothelial adhesion in human coronary artery endothelial cells ( HCAECs ) . Positive_regulation ICAM1 TNF 17434980 1772097 Anandamide dose dependently attenuated the *induced* [ICAM-1] and VCAM-1 expression , NF-kappaB activation in HCAECs , and the adhesion of monocytes to HCAECs in a CB(1)- and CB(2) dependent manner . Positive_regulation ICAM1 TNF 17467021 1743417 Inhibition of ERK , JNK , or NF-kappaB attenuates *induced* [ICAM-1] promoter activation and monocyte-endothelial monolayer binding . Positive_regulation ICAM1 TNF 17476188 1783638 Low-dose irradiation stimulates *induced* [ICAM-1] mRNA expression in human coronary vascular cells . Positive_regulation ICAM1 TNF 17498286 1744457 Part I of the study investigated in cytoflow studies the effect of SRL ( 0.01-1000 ng/ml ) on *induced* expression of [intercellular adhesion molecule 1] ( ICAM-1 ) in human coronary endothelial cells ( HCAEC ) and human coronary smooth muscle cells ( HCMSMC ) . Positive_regulation ICAM1 TNF 17548155 1762592 Among 13 different ginsenosides , intestinal bacterial metabolites Rh ( 2 ) and compound K ( C-K ) showed a significant inhibitory effect on *induced* expression of [intercellular adhesion molecule-1] in human astroglial cells . Positive_regulation ICAM1 TNF 17607964 1765402 The cultures pretreated with Epo reduced [ICAM-1] and PECAM-I expression *induced* by from 70.0 +/- 3.94 % to 59.3 +/- 0.60 % and from 83.4 +/- 2.27 % to 57.7 +/- 0.66 % respectively for ICAM-1 and PECAM-1 . Positive_regulation ICAM1 TNF 17652447 1822208 In addition , we have assessed the role of the CB(2) receptor in *induced* [ICAM-1] and VCAM-1 expression in human liver sinusoidal endothelial cells ( HLSECs ) and in the adhesion of human neutrophils to HLSECs in vitro . Positive_regulation ICAM1 TNF 17652447 1822214 HU-308 also attenuated the *induced* [ICAM-1] and VCAM-1 expression in HLSECs , which expressed CB(2) receptors , and the adhesion of human neutrophils to HLSECs in vitro . Positive_regulation ICAM1 TNF 17683945 1781398 The interaction between myocardial depressant factors in endotoxemic cardiac dysfunction : *role* of in TLR4 mediated [ICAM-1] expression . Positive_regulation ICAM1 TNF 17689945 1882302 Here , we have evaluated the effect of Piper longum chloroform extract (PlCE) on *induced* expression of [ICAM-1] on endothelial cells and on NADPH catalyzed rat liver microsomal lipid peroxidation with a view to identify modulators for the expression of CAMs . Positive_regulation ICAM1 TNF 17692965 1937802 DS and SQ significantly attenuated *induced* expression of adhesion molecule VCAM-1 and also [ICAM-1] by DS in the cells . Positive_regulation ICAM1 TNF 17707916 1789123 The presence of ciclesonide in cell cultures induced a significant downregulation of : ( a ) bFGF induced fibroblast proliferation and *induced* [ICAM-1] expression , at the 0.3-9.0 microM concentrations ( p < 0.05 ) ; Positive_regulation ICAM1 TNF 17822279 1497195 It also inhibited *induced* expression of [intercellular adhesion molecule-1] ( ICAM-1 ) , vascular cell adhesion molecule-1 ( VCAM-1 ) , and E-selectin . Positive_regulation ICAM1 TNF 17916277 1874111 Walnut extract and ellagic acid decreased significantly the *induced* endothelial expression of both VCAM-1 and [ICAM-1] ( P < 0.01 ; Positive_regulation ICAM1 TNF 17929893 1819638 Compounds 1 and 2 inhibited induced *up-regulation* of vascular cell adhesion molecule-1 ( VCAM-1 ) and [intercellular adhesion molecule-1] ( ICAM-1 ) , which also prevented adhesion of monocytes to HUVECs , and slightly suppressed the mRNA expression of the inflammation associated gene interleukin-1beta (IL-1beta) . Positive_regulation ICAM1 TNF 17988550 1821565 The inflammatory mediator [intercellular adhesion molecule-1] ( ICAM-1 ) expression in *response* to lipopolysaccharide and was compared between adenovirus E1A positive clones , control clones and CCL149 cells . Positive_regulation ICAM1 TNF 17988550 1821569 The results indicate that E1A upregulates [ICAM-1] expression *induced* by lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation ICAM1 TNF 18025230 1827737 Basal and *induced* expression of VCAM-1 , [ICAM-1] , and E-selectin were increased in Hmox1 ( -/- ) vs Hmox1 ( +/+ ) EC , an effect reversed by Fe chelation using deferoxamine mesylate ( DFO ) . Positive_regulation ICAM1 TNF 18206249 1876640 Peroxisome proliferator activated receptor gamma agonists suppress *induced* [ICAM-1] expression by endothelial cells in a manner potentially dependent on inhibition of reactive oxygen species . Positive_regulation ICAM1 TNF 18206249 1876641 Pretreatment with PPARgamma agonists abrogated *induced* expression of [intercellular adhesion molecule-1] ( ICAM-1 ) and subsequent monocytic adhesion by endothelial cells . Positive_regulation ICAM1 TNF 18206249 1876642 Consistent with previous reports in other cell types , blockade of TNFalpha induced ROS by treatment with N-acetylcysteine , diphenylene iodonium or NADPH oxidase 4 (NOX4) siRNA suppressed *induced* [ICAM-1] expression and subsequent monocytic adhesion , indicating that TNFalpha mediates pro-inflammatory signals via NOX4 dependent ROS generation in human endothelial cells . Positive_regulation ICAM1 TNF 18230913 1931798 also *enhanced* [ICAM-1] expression on TRs through nuclear factor-kappaB activation . Positive_regulation ICAM1 TNF 18255343 1877295 *induced* upregulation of the expression of inflammatory genes interleukin (IL)-8 and [intracellular adhesion molecule (ICAM)-1] was attenuated by incubation with DHEAS . Positive_regulation ICAM1 TNF 18287248 1896540 Flavopiridol also inhibited the induced *induction* of [intercellular adhesion molecule-1] , c-Myc , and c-Fos , all known to mediate tumorigenesis . Positive_regulation ICAM1 TNF 18292233 1885520 In organ culture , *induced* expression of E-selectin , VCAM-1 , and [ICAM-1] on HUVECs but only ICAM-1 on HUAECs . Positive_regulation ICAM1 TNF 18303186 1873576 While recombinant human *augmented* [CD54] and CD40 expression in a dose dependent manner , rhTNF-alpha did not increase CD86 expression . Positive_regulation ICAM1 TNF 18304597 1912009 Elevated HO-1 protein levels were associated with the inhibition of *induced* [ICAM-1] expression . Positive_regulation ICAM1 TNF 18387509 1893179 The goal of this study was to investigate the differential effect of hesperidin , hesperidin methyl chalone and phellopterin derived from P. trifoliata ( Rutaceae ) on the *induction* of [intercellular adhesion molecule-1] ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) by and the possible molecular mechanisms by which they differentially regulate ICAM-1 and VCAM-1 expressions . Positive_regulation ICAM1 TNF 18387509 1893183 Stimulation of human umbilical vein endothelial cells ( HUVECs ) with *resulted* in the increase of [ICAM-1] and VCAM-1 expressions , while pretreatment with the three components completely inhibited VCAM-1 expression in a dose dependent manner but had no effect on ICAM-1 expression . Positive_regulation ICAM1 TNF 18387509 1893186 Furthermore , they efficiently inhibited the phosphorylation of Akt and PKC , suggesting that Akt or PKC pathways are an important target by which these compounds regulate *induced* VCAM-1 but not [ICAM-1] . Positive_regulation ICAM1 TNF 18391098 1899295 Moreover , kallistatin attenuated *induced* [intercellular adhesion molecule-1] and vascular cell adhesion molecule-1 expression via inhibition of reactive oxygen species formation and p38 mitogen activated protein kinase and nuclear factor-kappaB activation in cultured proximal tubular cells . Positive_regulation ICAM1 TNF 18439578 1915598 Lycopene inhibits *induced* endothelial [ICAM-1] expression and monocyte-endothelial adhesion . Positive_regulation ICAM1 TNF 18439578 1915599 We found that *induced* [intercellular adhesion molecule-1] ( ICAM-1 ) expression in HUVECs was inhibited by lycopene , whereas cyclooxygenase-2 (COX-2) and platelet-endothelial cell adhesion molecule ( PECAM-1 ) expression were not affected . Positive_regulation ICAM1 TNF 18439578 1915608 Taken together , we provided here the first evidence showing that lycopene is able to inhibit *induced* NF-kappaB activation , [ICAM-1] expression , and monocyte-endothelial interaction , suggesting an anti-inflammatory role of lycopene and possibly explaining in part why lycopene can prevent cardiovascular diseases . Positive_regulation ICAM1 TNF 18446055 1902762 induced *up-regulation* of [intercellular adhesion molecule-1] is regulated by a Rac-ROS dependent cascade in human airway epithelial cells . Positive_regulation ICAM1 TNF 18446055 1902763 Further , we found out that expression of RacN17 , a dominant negative mutant of Rac1 , suppressed *induced* ROS generation , [ICAM-1] expression , and monocyte adhesion to airway epithelium . Positive_regulation ICAM1 TNF 18446055 1902764 Finally , pretreatment with pyrrolidine dithiocarbamate ( PDTC ) , an inhibitor of NF-kappaB , reduced *induced* [ICAM-1] expression and both DPI and RacN17 significantly diminished NF-kappaB activation in response to TNF-alpha . Positive_regulation ICAM1 TNF 18475445 209526 Since [ICAM-1] is not constitutively expressed on normal human articular cartilage , but could be *induced* in vitro by exogenous IL-1alpha , and IFNgamma or by co-culturing cartilage with inflammatory rheumatoid synovium , we conclude that the induction of ICAM-1 on rheumatoid chondrocytes results from the synergistic action of a variety of cytokines produced by the inflammatory cells of the invading pannus . Positive_regulation ICAM1 TNF 18475479 209537 Stimulation of endothelial cells by *induces* the expression of [intercellular adhesion molecule-1] ( ICAM-1 ) , which is an important early marker of immune activation and response . Positive_regulation ICAM1 TNF 18486623 1927687 Post-transcriptional regulation of *induced* expression of [ICAM-1] and IL-8 in human lung microvascular endothelial cells : an obligatory role for the p38 MAPK-MK2 pathway dissociated with HSP27 . Positive_regulation ICAM1 TNF 18486623 1927719 We evaluated the role of p38 MAPK , MK2 and HSP27 in regulating the *induced* expression of [ICAM-1] and IL-8 in human lung MVECs . Positive_regulation ICAM1 TNF 18486623 1927835 Our study demonstrates for the first time that MK2 mediates post-transcriptional regulation by p38 MAPK of the *induced* expression of [ICAM-1] and IL-8 in human lung MVECs , and that this regulation by the p38 MAPK/MK2 pathway is dissociated from HSP27 phosphorylation . Positive_regulation ICAM1 TNF 18487372 1951675 Upregulation of TNFR1 expression by priming with TAPI-2 and IFNgamma resulted in enhanced [ICAM-1] expression in *response* to stimulation ( significant change in the slope of the dose-response curve ) . Positive_regulation ICAM1 TNF 18489909 2019768 Quercetin was able to reduce induced *upregulation* of VCAM-1 , [ICAM-1] and MCP-1 at both the protein and transcript ( mRNA ) level in HUASMC . Positive_regulation ICAM1 TNF 18490752 1916993 LT failed to augment *induced* [ICAM-1] or E-selectin expression , two adhesion molecules regulated by NF-kappaB , but not IRF-1 . Positive_regulation ICAM1 TNF 18543247 1952095 In this context , small interfering RNA- ( siRNA ) -mediated `` aqp-3 gene silencing , '' which could reduce AQP3 expression by more than 65 % , significantly attenuated selected proinflammatory events of [ICAM-1] expression *induced* by in Ca9-22 . Positive_regulation ICAM1 TNF 18613029 1966205 The inhibition of SB at 10 microM on *induced* [ICAM-1] , VCAM-1 and E-selectin is likely due to the nonspecific effect of SB . Positive_regulation ICAM1 TNF 18642698 1840854 and lipopolysaccharide did not stimulate secretion of von Willebrand factor , but significantly *increased* the expression of [ICAM-1] . Positive_regulation ICAM1 TNF 18653650 1992658 IFN-beta significantly enhanced the expression of vascular cell adhesion molecule-1 and [intercellular adhesion molecule-1] on HUVECs in the *presence* of . Positive_regulation ICAM1 TNF 18656701 1942659 could significantly *induce* CCL2 , [ICAM-1] and VCAM-1 expression of PTEC . Positive_regulation ICAM1 TNF 18656701 1942690 Selective inhibitors of p38 MAPK ( SB203580 ) , JNK ( SP600125 ) and ERK ( PD98059 ) could suppress *induced* CCL2 and [ICAM-1] expression , while only p38 MAPK and ERK inhibitors could suppress TNF-alpha induced VCAM-1 expression . Positive_regulation ICAM1 TNF 1885218 165707 [ICAM-1] was *up-regulated* on TMF in culture by recombinant IFN-gamma , IL1 and and was down-regulated by dexamethasone . Positive_regulation ICAM1 TNF 18946195 1978809 Furthermore , the effects of ruscogenin on *induced* [intercellular adhesion molecule-1] ( ICAM-1 ) expression and nuclear factor-kappaB (NF-kappaB) activation were also investigated under consideration of their key roles in leukocyte recruitment . Positive_regulation ICAM1 TNF 18948845 2053230 Hypertonic saline significantly reduced *induced* [intercellular adhesion molecule 1] levels and NF-kappaB nuclear localization . Positive_regulation ICAM1 TNF 18988888 2015875 This study aimed to investigate the regulated expression of the newly identified adiponectin receptors ( AdipoR1 and 2 ) and their roles in the endothelial expression of [intercellular adhesion molecule-1] ( ICAM-1 ) in *response* to . Positive_regulation ICAM1 TNF 18988888 2015880 Immunohistochemical study and quantitative RT-PCR demonstrated that globular adiponectin suppressed the *induced* [ICAM-1] expression in a dose dependent manner in mouse aorta and human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation ICAM1 TNF 18988888 2015882 Adenovirus mediated overexpression of AdipoR1 and 2 in ECs significantly enhanced the suppressive effect of a subeffective dose of adiponectin on *induced* [ICAM-1] expression and NF-kappaB activation . Positive_regulation ICAM1 TNF 18989464 1983818 This study investigated the *induced* [ICAM-1] and VCAM-1 expression on mouse lingual lymphatic vessels . Positive_regulation ICAM1 TNF 19004511 2216456 We assessed the effect of SSRIs , ( citalopram , fluvoxamine and fluoxetine ) , on *induced* expression of VCAM-1 and [ICAM-1] in human aorta endothelial cells and adhesiveness to U937 monocytes . Positive_regulation ICAM1 TNF 19020780 1992181 The results demonstrated that glucosamine but not N-acetylglucosamine suppressed *induced* expression of MCP-1 and [ICAM-1] at both the mRNA and protein levels . Positive_regulation ICAM1 TNF 19020780 1992183 Thus , glucosamine is likely to suppress endothelial cell activation ( *induced* [ICAM-1] and MCP-1 expression ) possibly by affecting p38MAPK and NF-kappaB signaling via O-GlcNAc modification . Positive_regulation ICAM1 TNF 1906507 161762 IL-1 alpha , , and LPS *increased* [ICAM-1] expression on average 100-200 % whereas IFN gamma was somewhat less potent . Positive_regulation ICAM1 TNF 19136619 2047976 In this report , we demonstrate for the first time that the treatment with liraglutide , a long acting GLP-1 analogue , inhibited or hyperglycaemia mediated *induction* of PAI-1 , [intercellular adhesion molecule-1] and vascular cell adhesion molecule-1 mRNA and protein expression in a human vascular endothelial cell line . Positive_regulation ICAM1 TNF 19148111 2037983 ( 2 ) Digibind could attenuate and reduce induced *upregulation* of endothelial E-selectin , [ICAM] and VCAM expressions . Positive_regulation ICAM1 TNF 19159436 2038207 The decrease in *induced* rise in [ICAM-1] level was associated with a reduction of NF-kappaB activation , a reduction in mRNA expression of ICAM-1 , and a functional reduction in monocyte adhesion to cultured endothelial cells . Positive_regulation ICAM1 TNF 19236958 2054784 In addition , withaferin A inhibited *induced* expression of adhesion molecules ( [ICAM-1] and VCAM-1 ) protein and mRNA in a dose dependent manner . Positive_regulation ICAM1 TNF 19254713 2079629 Towards the mechanism , we showed that lovastatin ameliorated [ICAM-1] expression *induced* by hypoxia and in both RCECs and ARPE-19 cells , in part through inhibition of NF-kappaB activation . Positive_regulation ICAM1 TNF 19277846 2106025 One-hour pretreatment of endothelial cells ( EC ) with sulforaphane ( 1-4 muM ) suppressed TNF-alpha induced MCP-1 and VCAM-1 mRNA and protein levels , but had no effect on *induced* [ICAM-1] expression . Positive_regulation ICAM1 TNF 19284655 2055711 The *induction* of the expression of endothelial VCAM-1 , [ICAM-1] and E-selectin by was concentration-dependently reduced by incubation of the endothelial cells with the arginase inhibitor L-norvaline . Positive_regulation ICAM1 TNF 19284655 2055715 Silencing S6K1 prevented up-regulation of E-selectin , but not that of VCAM-1 or [ICAM-1] *induced* by . Positive_regulation ICAM1 TNF 19320886 2052445 The expression of [ICAM-1] could be *up-regulated* by 50 microg/L ( p < 0.05 ) , whereas that of VCAM-1 remained unchanged ( p > 0.05 ) . Positive_regulation ICAM1 TNF 19320886 2052449 TNF-alpha at 50 microg/L increased the expression of phospho-ERK and phospho-p38 , and SB203580 , but not PD98059 , could suppress the chemotaxis effect and up-regulation of [ICAM-1] *induced* by in MSCs ( p < 0.05 ) . Positive_regulation ICAM1 TNF 19338980 2064645 Role of the interferon-inducible IFI16 gene in the *induction* of [ICAM-1] by . Positive_regulation ICAM1 TNF 19338980 2064650 Our studies demonstrate that IFI16 mediates [ICAM-1] *stimulation* by through the NF-kappaB pathway , thus reinforcing the role of the IFI16 molecule in the inflammation process . Positive_regulation ICAM1 TNF 19351910 2088770 In contrast , NFATc1 knockdown had no effect on *induced* [ICAM-1] expression . Positive_regulation ICAM1 TNF 19356108 2007934 Increased adiponectin levels were associated with a decrease in *induced* [ICAM-1] and VCAM-1 and caspase 3 activity in endothelial cells while phosphorylation of eNOS at Ser-1179 increased . Positive_regulation ICAM1 TNF 19358606 2074526 Interestingly , we report the first evidence that monophenols tyrosol and p-coumaric acid are selectively protective only in homocysteine activated cells , while they are ineffective in reducing [ICAM-1] expression *induced* by . Positive_regulation ICAM1 TNF 19367378 2081651 Reverse transcription-PCR and Western blot analyses revealed that Klotho suppressed *induced* expression of intracellular adhesion molecule-1 ( [ICAM-1] ) and vascular cell adhesion molecule-1 ( VCAM-1 ) . Positive_regulation ICAM1 TNF 19371606 2058827 Arsenite pretreatment , which upregulated HO-1 in a time- and concentration dependent manner , inhibited *induced* monocyte adhesion to HUVEC and [intercellular adhesion molecule 1] protein expression by 50 % and 40 % , respectively . Positive_regulation ICAM1 TNF 19389799 2100748 These inhibitory responses of GW501516 on activated endothelium were accompanied by a reduction in *induced* endothelial GRO-alpha release and VCAM-1 , E-selectin , and [ICAM-1] mRNA expression . Positive_regulation ICAM1 TNF 19420112 2106634 However , the broad-spectrum caspase inhibitor Boc-d-fmk reduced NF-kB activation as assessed by gel shift assay , reduced phosphorylation of subunit IkappaBalpha , and significantly inhibited *induced* expression of [ICAM-1] and VCAM-1 as assessed by both real-time PCR and flow cytometry . Positive_regulation ICAM1 TNF 19439196 2101370 Experimental results indicated that 2-TeCD suppressed the *induced* the expression of vascular adhesion molecule-1 (VCAM-1) and intercellular cell adhesion molecule-1 ( [ICAM-1] ) on HUVECs surface in a dose dependent manner . Positive_regulation ICAM1 TNF 19439196 2101373 In short , these results indicated that 2-TeCD inhibits *stimulated* VCAM-1 and [ICAM-1] expression in HUVECs partly due to suppressing translocation of NF-kappaB . Positive_regulation ICAM1 TNF 19523446 2103169 In HUVEC cells , UCB blunted the induced gene *upregulation* of E-selectin VCAM-1 and [ICAM-1] . Positive_regulation ICAM1 TNF 19559678 2136666 Odoroside A [ 3beta-O- ( beta-D-diginosyl ) -14-hydroxy-5beta,14beta-card-20 ( 22 ) -enolide ] was found to inhibit the cell-surface expression of [ICAM-1] *induced* by and IL-1 at comparable concentrations in human lung carcinoma A549 cells . Positive_regulation ICAM1 TNF 19559678 2136668 In this study , the molecular mechanism underlying the inhibition of *induced* cell-surface [ICAM-1] expression by odoroside A together with the specific Na ( + ) /K ( + ) -ATPase inhibitor ouabain was further investigated . Positive_regulation ICAM1 TNF 19559678 2136669 While odoroside A and ouabain had no inhibitory effect on the induction of ICAM-1 mRNA , they inhibited the *induced* [ICAM-1] expression at the protein level . Positive_regulation ICAM1 TNF 19571567 2162506 To investigate the mechanism of the inhibitory action of procaterol , *induced* expression of adhesion molecules , [ICAM-1] and VCAM-1 , in NHLF was also evaluated . Positive_regulation ICAM1 TNF 19607809 2123917 OA-NO ( 2 ) and LNO ( 2 ) also blocked *induced* expression of the adhesion molecules , [ICAM-1] , VCAM-1 , and E-selectin , and suppressed monocyte adhesion to HUVECs . Positive_regulation ICAM1 TNF 19608869 2112255 In addition , HO-1 overexpression inhibited *induced* [intercellular adhesion molecule-1] and vascular cell adhesion molecule-1 expression , adherence of THP-1 cells , generation of interleukin-6 , p47(phox) translocation , and nuclear factor-kappaB activation . Positive_regulation ICAM1 TNF 19617655 2112463 Pretreatment of HUVEC with propionate significantly inhibited the *induced* expression of vascular cell adhesion molecule-1 ( VCAM-1 ) and intracellular adhesion molecule-1 ( [ICAM-1] ) in a time- and dose dependent manner . Positive_regulation ICAM1 TNF 19627149 2180257 Stimulation of cells with *increased* [ICAM-1] and VCAM-1 expression , and pretreatment with anthocyanins inhibited VCAM-1 expression , but not ICAM-1 expression . Positive_regulation ICAM1 TNF 19627149 2180260 We found that IRF-1 and GATAs , especially GATA-4 and -6 , were involved in the *mediated* expression of VCAM-1 but not [ICAM-1] , and anthocyanins decreased nuclear levels of GATA-4 and GATA-6 as well as IRF-1 . Positive_regulation ICAM1 TNF 19627149 2180269 This suggests that anthocyanins differentially regulate *mediated* expression of VCAM-1 and [ICAM-1] through modulation of the GATA and IRF-1 binding activity via Jak/STAT-3 activation . Positive_regulation ICAM1 TNF 19661147 2150526 In stromal cultures derived from control women and those with endometriosis , *augmented* the intracellular proMMP1 ( 1.2-fold in control stromal cells ) and [ICAM1] ( 1.4- and 1.9-fold ) , greatly increased MMP1 and proMMP9 levels , and the sICAM1 concentration ( 2.3- and 4.3-fold ) in their media compared with basal levels . Positive_regulation ICAM1 TNF 1967270 126726 By using the mAb RR1/1 , we have determined that c3Ado also inhibited the *induced* expression of [ICAM-1] on the surface of the HEC , as well as cytosol associated ICAM-1 . Positive_regulation ICAM1 TNF 19674910 2126170 Inhibitory effect of beta-diketones and their metal complexes on *induced* expression of [ICAM-1] on human endothelial cells . Positive_regulation ICAM1 TNF 1974278 137332 To our knowledge , this is the first report of melanocyte [ICAM-1] *induction* by and IL-1 alpha and by physiologically relevant doses of IFN-G . Positive_regulation ICAM1 TNF 19800320 2153886 however , it enhanced *induced* expression of [intracellular adhesion molecule (ICAM)-1] as well as activation of c-Jun N-terminal kinase (JNK) . Positive_regulation ICAM1 TNF 19801900 2148235 Furthermore , vaspin did not decrease the ( 24 hr ) *induction* of vascular cell adhesion molecule-1 , [intercellular adhesion molecule-1] , endothelial selectin , and cyclooxygenase-2 protein expression as well as monocyte chemotactic protein-1 , tissue factor , and plasmogen activator inhibitor-1 mRNA expression . Positive_regulation ICAM1 TNF 1982501 149818 *induced* [ICAM-1] expression on ICAM-1- tumor cells , and simultaneously increased target cell susceptibility to MHC unrestricted as well as to anti-CD16 mAb triggered lysis . Positive_regulation ICAM1 TNF 19875721 2187913 CD31 ( + ) cells purified from differentiating EBs upregulated [ICAM-1] and VCAM-1 in *response* to , confirming their ability to function as endothelial cells . Positive_regulation ICAM1 TNF 19949084 2190697 Cutting edge : TNF induced microRNAs regulate *induced* expression of E-selectin and [intercellular adhesion molecule-1] on human endothelial cells : feedback control of inflammation . Positive_regulation ICAM1 TNF 19965776 2199569 In HCAECs , both 5A/PLPC and ( A-I ) rHDL inhibited *induced* [intercellular adhesion molecule-1] and vascular cell adhesion molecule-1 expression , as well as the nuclear factor kappaB signaling cascade and production . Positive_regulation ICAM1 TNF 20007578 2174979 In human pulmonary microvascular ECs , AR activity was required for *induced* activation of the Rho kinase/MKK4/JNK pathway and IL-6 production , but not p38 activation or [ICAM-1] expression . Positive_regulation ICAM1 TNF 20016245 2200100 The protein and mRNA levels of *induced* [ICAM-1] , VCAM-1 and E-selectin were determined in HUVECs . Positive_regulation ICAM1 TNF 20016245 2200102 Puerarin inhibited the expression of *induced* [ICAM-1] , VCAM-1 and E-selectin proteins and mRNAs in HUVECs . Positive_regulation ICAM1 TNF 20016245 2200105 These data suggested that the effect of puerarin mediated inhibition of *induced* [ICAM-1] , VCAM-1 and E-selectin expression is attributed to suppressed NF-kappaB activation on the transcriptional level . Positive_regulation ICAM1 TNF 20045926 2192890 Deoxypodophyllotoxin inhibits the expression of [intercellular adhesion molecule-1] *induced* by in murine lung epithelial cells . Positive_regulation ICAM1 TNF 20045926 2192894 DPT ( 5 to 20 nM ) inhibited *induced* [ICAM-1] expression through nuclear factor-kappa B (NF-kappaB) in a dose dependent manner and repressed ICAM-1 promoter activity . Positive_regulation ICAM1 TNF 20101252 2219335 Interestingly , overexpression of icIL-1ra also inhibited *induced* upregulation of [ICAM-1] . Positive_regulation ICAM1 TNF 20153559 2242499 At 10 microM the *induced* expression of [ICAM-1] was significantly reduced to 65.8 and 69.6 % of control , respectively . Positive_regulation ICAM1 TNF 20156602 2236155 In addition , BAI inhibited *induced* expression of adhesion molecules ( [ICAM-1] and VCAM-1 ) protein and mRNA in a dose dependent manner . Positive_regulation ICAM1 TNF 20158572 2401316 *up-regulated* [ICAM-1] , a ( v ) ß ( 3 ) and FKN expression on HIMEC . Positive_regulation ICAM1 TNF 20226872 2272756 In the presence of PGE ( 2 ) ( 1 nM ) , roflumilast N-oxide reduced *induced* [ICAM-1] and eotaxin by about 70 % and > 90 % with half-maximum inhibition at 0.9 nM and 0.5 nM , respectively . Positive_regulation ICAM1 TNF 20306475 2315259 When HAECs were pretreated with sesamin ( 10 or 100 microM ) , the *induced* expression of intercellular cell adhesion molecule-1 ( [ICAM-1] ) was significantly reduced ( 35 or 70 % decrease , respectively ) by Western blotting . Positive_regulation ICAM1 TNF 20306475 2315262 Sesamin significantly attenuated *induced* [ICAM-1] expression and cell adhesion by downregulation of extracellular signal regulated kinase 1/2 and p38 . Positive_regulation ICAM1 TNF 20351055 2273279 ECs treated with GSH and H ( 2 ) O ( 2 ) show increased sulfhydryl modifications of the p65 subunit of nuclear factor kappa-light-chain-enhancer of activated B cells ( NF-kappaB ) , which are responsible for NF-kappaB inactivation , and also a block in *induced* p65 nuclear translocation and [inter-cellular adhesion molecule-1] ( ICAM-1 ) expression . Positive_regulation ICAM1 TNF 20351055 2273281 In our current study , we find that cinnamaldehyde induces p65 glutathionylation and inhibits *induced* p65 nuclear translocation and [ICAM-1] expression within 12 h of treatment . Positive_regulation ICAM1 TNF 20418897 2256451 Finally , pretreatment with GA or the inhibitors of NF-kappaB , JNK , and p38 reduced the [ICAM-1] protein expression *induced* by . Positive_regulation ICAM1 TNF 20418897 2256452 GA inhibits *stimulated* [ICAM-1] expression , leading to a decrease in adherent monocytes to HUVEC . Positive_regulation ICAM1 TNF 20431193 2247462 bound to 14 nm CB *induced* a level of [ICAM-1] expression that was no greater than the control level , suggesting that the TNF-alpha activity may be inhibited . Positive_regulation ICAM1 TNF 20511548 2276904 IFN-gamma and synergistically *enhanced* the expression of [CD54] by MSCs , enabling the CCR6 chemokine ligand CCL20 to induce in vitro adhesion of Th17 cells to MSCs . Positive_regulation ICAM1 TNF 20557886 2308777 Q-real-time PCR and protein array approaches confirmed that *induced* [ICAM-1] , VCAM-1 and ELAM-1 as well as MCP-1 and IL-6 induction was affected upon 3beta-Adiol pre-incubation . Positive_regulation ICAM1 TNF 20592773 2181647 We recently demonstrated that hyperglycemia increases oxidative stress and HBP flux in endothelial cells and enhances endothelial expression of vascular adhesion molecule-1 (VCAM-1) and [intercellular adhesion molecule-1] ( ICAM-1 ) in *response* to through oxidative stress rather than HBP pathway . Positive_regulation ICAM1 TNF 20592773 2181651 Here we present further complementary data showing that enhancing O-GlcNAc levels by glucosamine does not mimic hyperglycemia 's effect on *induced* endothelial VCAM-1 and [ICAM-1] expression . Positive_regulation ICAM1 TNF 20657842 2293427 *induced* a robust activation of MMP-9 , [ICAM-1] , and the IL-8 promoter driven reporter in Thy-1- MEFs , in contrast to only a modest increase in Thy-1+ counterparts . Positive_regulation ICAM1 TNF 20674161 2317170 Additionally , TNF-a , a typical inflammatory cytokine , induced ICAM-1 expression in an NF-?B dependent manner , and ZnO synergistically enhanced *induced* [ICAM-1] expression . Positive_regulation ICAM1 TNF 20687137 2388893 Together , these results suggest that Tan IIA regulates *induced* expression of VCAM-1 and [ICAM-1] through inhibition of NF-?B activation and ROS generation in BMVECs . Positive_regulation ICAM1 TNF 20724805 2306872 In the present studies , we further examined its effects on the main signaling pathways involved in upregulation of [ICAM-1] *induced* by in human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation ICAM1 TNF 20851151 2368662 The effect of relaxin coincubation on the *stimulated* expression of the adhesion molecules VCAM-1 , [ICAM-1] and E-selectin ; Positive_regulation ICAM1 TNF 20871620 2326281 Further , it attenuated the down-regulation of vascular endothelial cadherin and the up-regulation of [ICAM-1] *induced* by . Positive_regulation ICAM1 TNF 20878699 2326559 Preincubation with ATO ( 20 µg/mL ) suppressed *induced* expression of adhesion molecules including [intercellular adhesion molecule-1] ( ICAM-1 ) , vascular cell adhesion molecule-1 ( VCAM-1 ) and E-selectin at both the protein and mRNA levels . Positive_regulation ICAM1 TNF 20946932 2369223 7,8-didehydrocimigenol from Cimicifugae rhizoma inhibits *induced* VCAM-1 but not [ICAM-1expression] through upregulation of PPAR-? in human endothelial cells . Positive_regulation ICAM1 TNF 20966395 2365254 By using human umbilical vein endothelial cells ( HUVECs ) , we showed that Erg overexpression by adenovirus ( AdErg ) repressed basal and *induced* expression of [intercellular adhesion molecule-1] ( ICAM-1 ) , vascular cell adhesion molecule ( VCAM ) , and interleukin 8 (IL-8) . Positive_regulation ICAM1 TNF 20966395 2365260 Erg inhibited *dependent* activation of the [ICAM-1] promoter , nuclear factor ( NF ) -?B activity , and NF-?B p65 phosphorylation . Positive_regulation ICAM1 TNF 21138840 2384303 Finally , in vivo studies show that activation of XBP1 by ER stress preconditioning prevents *induced* [ICAM-1] and VCAM-1 expression , leukostasis , and vascular leakage in mouse retinas . Positive_regulation ICAM1 TNF 21223991 2397188 Gossypol decreases *induced* [intercellular adhesion molecule-1] expression via suppression of NF-?B activity . Positive_regulation ICAM1 TNF 21223991 2397189 This study aims to investigate the effect of gossypol on *stimulated* [ICAM-1] via nuclear factor-kappa B ( NF-?B ) activity . Positive_regulation ICAM1 TNF 21223991 2397190 Gossypol was shown to inhibit *induced* [ICAM-1] expression and U937 cell adhesion to MDA-MB-231 and MCF-7 cells . Positive_regulation ICAM1 TNF 21223991 2397191 Taken together , gossypol effectively inhibited *induced* [ICAM-1] expression via the suppression of NF-?B activation and in vitro adhesion and invasion in human breast cancer cells . Positive_regulation ICAM1 TNF 21239709 2386788 These results indicate that hapten application to the skin of sensitized animals initiates an inflammatory response promoting hapten primed CD8 T cell localization to the challenge site through *induced* [ICAM-1] expression and CD8 T cell activation to produce IFN-? and IL-17 through endothelial cell presentation of hapten . Positive_regulation ICAM1 TNF 21305449 2447639 Catechol , a bioactive degradation product of salicortin , reduces *induced* [ICAM-1] expression in human endothelial cells . Positive_regulation ICAM1 TNF 21349589 2399583 Stimulation of endothelial monolayers with *resulted* in significant increase of toll-like receptor 4 , interleukin-6 and -8 , and [intercellular adhesion molecule-1] and vascular cellular adhesion molecule-1 gene expression in a time dependent manner . Positive_regulation ICAM1 TNF 21445895 2443713 Immunoblot analysis showed that Monascus fermented rice metabolites significantly attenuated *induced* VCAM-1 and E-selectin but not [ICAM-1] protein expression . Positive_regulation ICAM1 TNF 21448188 2432397 Here , we report that mycotrienin II , a member of the triene-ansamycin group , inhibited the cell-surface [ICAM-1] expression *induced* by more strongly than that induced by IL-1a in human lung carcinoma A549 cells . Positive_regulation ICAM1 TNF 21448188 2432398 Among translation inhibitors tested , acetoxycycloheximide and anisomycin , but neither puromycin nor emetine , inhibited the *induced* [ICAM-1] expression at lower concentrations than the IL-1a induced ICAM-1 expression . Positive_regulation ICAM1 TNF 21474822 2428166 The goal of this study was to determine whether *induced* Src activation and [intercellular adhesion molecule-1] ( ICAM-1 ) phosphorylation rapidly increase endothelial cell adhesivity and polymorphonuclear leukocyte ( PMN ) sequestration independently of de novo ICAM-1 synthesis . Positive_regulation ICAM1 TNF 21491909 2428467 A previous study demonstrated the role of heme oxygenase 1 (HO-1) in the inhibition of *induced* [ICAM-1] expression by AP . Positive_regulation ICAM1 TNF 21491909 2428470 The present study investigated the effect of AP on the IKK/NF-?B signaling pathway , which mediates *induced* [ICAM-1] expression in EA.hy926 cells . Positive_regulation ICAM1 TNF 21491909 2428472 Although AP increased the intracellular cAMP concentration and induced the phosphorylation of cAMP response element binding protein ( CREB ) , knocking down CREB protein expression by transfecting the cells with CREB-specific small interfering RNA did not relieve the inhibition of ICAM-1 expression by AP. Taken together , these results suggest that AP down-regulates *induced* [ICAM-1] expression at least in part via attenuation of activation of NF-?B in EA.hy926 cells rather than through activation of CREB . Positive_regulation ICAM1 TNF 21621513 2446014 Casuarinin suppresses *induced* [ICAM-1] expression via blockade of NF-?B activation in HaCaT cells . Positive_regulation ICAM1 TNF 21621513 2446015 In this study , we isolated casuarinin from the leaves of H.rhamnoides and examined the effect of casuarinin on the *induced* [ICAM-1] expression in a human keratinocytes cell line HaCaT . Positive_regulation ICAM1 TNF 21621513 2446016 These results demonstrated that casuarinin exerts its anti-inflammatory activity by suppressing *induced* expression of [ICAM-1] and pro-inflammatory cytokines/chemokines via blockage of activation of NF-?B and ERK/p38 MAPK and can be used as a therapeutic agent against inflammatory skin diseases . Positive_regulation ICAM1 TNF 21626431 2454637 Indeed , levosimendan increased cyclic guanosine monophosphate ( cGMP ) in human umbilical vein endothelial cells ( HUVECs ) and impaired the *induced* inflammatory expression of E-selectin , [intercellular adhesion molecule-1] ( ICAM-1 ) , cyclooxygenase-2 (COX-2) , and monocyte chemotactic protein-1 (MCP-1) . Positive_regulation ICAM1 TNF 21663740 2470824 In human lung carcinoma A549 cells , cytotrienin A was found to inhibit more strongly the cell-surface expression of [intercellular adhesion molecule-1] ( ICAM-1 ) *induced* by than the expression induced by interleukin (IL)-1a . Positive_regulation ICAM1 TNF 21663740 2470826 Thus , our present results demonstrate that cytotrienin A is a translation inhibitor that triggers ribotoxic stress response and selectively inhibits the *induced* [ICAM-1] expression by inducing the ectodomain shedding of TNF receptor 1 via the activation of ERK and p38 MAP kinase . Positive_regulation ICAM1 TNF 21719737 2471309 IL-18 did not enhance *induced* expression of [intercellular adhesion molecule-1] or IL-8 in LS174T . Positive_regulation ICAM1 TNF 21764059 2500178 In both DN-AMPK- and AMPKa ( 1 ) -siRNA transfected HUVECs , compound C still inhibited *induced* VCAM-1 and [ICAM-1] expression , indicating that this is AMPK independent action . Positive_regulation ICAM1 TNF 21777697 2509918 ZLJ-6 , a novel COX/5-LOX inhibitor , attenuates *induced* endothelial E-selectin , [ICAM-1] and VCAM-1 expression and monocyte-endothelial interactions via a COX/5-LOX independent mechanism . Positive_regulation ICAM1 TNF 21820422 2490439 Triptolide also abrogated *induced* expression of cell survival proteins ( XIAP , Bcl-x ( L ) , Bcl-2 , survivin , cIAP-1 and cIAP-2 ) , cell proliferative proteins ( cyclin D1 , c-myc and cyclooxygenase-2 ) , and metastasis proteins ( [ICAM-1] and MMP-9 ) . Positive_regulation ICAM1 TNF 21852236 2490736 Suppression of GPx-1 enhanced *induced* ROS production and [ICAM-1] expression , whereas overexpression of GPx-1 attenuated these TNF-a mediated responses . Positive_regulation ICAM1 TNF 21852236 2490740 JNK or NF?B inhibition attenuated *induction* of [ICAM-1] and VCAM-1 expression in GPx-1-deficient and control cells , whereas ERK1/2 inhibition attenuated only VCAM-1 expression . Positive_regulation ICAM1 TNF 21981016 2547160 We investigated how expression of [ICAM-1] , VCAM-1 , MAdCAM-1 , PECAM-1 , E- and P-selectin in *response* to , IL-1ß and IFN-? was altered by aglycemia ( A ) , hypoxia ( H ) or combined oxygen glucose deprivation ( OGD ) . Positive_regulation ICAM1 TNF 21982436 2547170 All compounds were investigated for their activity on *induced* [ICAM-1] expression . Positive_regulation ICAM1 TNF 22000995 2526254 Pentoxifylline markedly reduced the expression of [Icam1] and iNos *induced* by in vitro in AR42J cells . Positive_regulation ICAM1 TNF 22000995 2526256 Oxidative stress significantly contributes to the *induced* up-regulation of [Icam] and iNos in AR42J cells . Positive_regulation ICAM1 TNF 22026410 2513646 Andrographolide ( 1 ) , an active constituent of Andrographis paniculata , decreased *induced* [intercellular adhesion molecule-1] ( ICAM-1 ) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells ( HUVEC ) , which are associated with inflammatory diseases . Positive_regulation ICAM1 TNF 22026410 2513651 Compound 1 exhibits anti-inflammatory properties through the inhibition of *induced* [ICAM-1] expression . Positive_regulation ICAM1 TNF 22045868 2540195 Natural killer cell produced IFN-? and *induce* target cell cytolysis through up-regulation of [ICAM-1] . Positive_regulation ICAM1 TNF 22138303 2536197 While PCXII cells exhibited reduced *induced* cell surface [ICAM-1] expression , IkB phosphorylation and degradation were similar to control cells . Positive_regulation ICAM1 TNF 22182512 2543286 Down-regulation of JNK by a specific inhibitor ( SP600125 ) or dominant negative ( DN ) JNK1 plasmid enhanced *induced* VCAM-1 but not [ICAM-1] expression . Positive_regulation ICAM1 TNF 22182512 2543289 Next , we investigated whether JNK signaling affects IRF-1 and/or GATA6 , which are transcription factors that mediate *induction* of VCAM-1 but not [ICAM-1] . Positive_regulation ICAM1 TNF 22183741 2617276 Endometriotic stromal cells treated with curcumin showed marked suppression of *induced* mRNA expression of [ICAM-1] and VCAM-1 . Positive_regulation ICAM1 TNF 22183741 2617278 Curcumin treatment also significantly decreased the *induced* cell surface and total protein expression of [ICAM-1] and VCAM-1 in a dose dependent manner . Positive_regulation ICAM1 TNF 22210374 2549838 Pretreatment of VSMCs for 2h with stereocalpin A at nontoxic concentrations of 0.1-10 µg/ml inhibited *induced* adhesion of THP-1 monocytic cells and expression of vascular cell adhesion molecule-1 ( VCAM-1 ) and [intercellular adhesion molecule-1] ( ICAM-1 ) . Positive_regulation ICAM1 TNF 22226679 2544561 Human lactoferrin suppresses *induced* [intercellular adhesion molecule-1] expression via competition with NF-?B in endothelial cells . Positive_regulation ICAM1 TNF 22226679 2544562 Here , we demonstrated that *induced* expression of [intercellular adhesion molecule-1] ( ICAM-1 ) was down-regulated by Lf in a DNA binding dependent manner at transcriptional level in endothelial cells . Positive_regulation ICAM1 TNF 22268119 2580095 MK2 posttranscriptionally regulates *induced* expression of [ICAM-1] and IL-8 via tristetraprolin in human pulmonary microvascular endothelial cells . Positive_regulation ICAM1 TNF 22268119 2580101 A previous study by our group showed that MK2 regulates *induced* expression of [intercellular adhesion molecule-1] ( ICAM-1 ) and interleukin-8 (IL-8) in human lung microvascular endothelial cells ; Positive_regulation ICAM1 TNF 22268119 2580107 In the present study , we performed experiments to determine whether MK2 regulates *induced* expression of [ICAM-1] and IL-8 via TTP in human pulmonary microvascular endothelial cells ( HPMECs ) . Positive_regulation ICAM1 TNF 22268119 2580113 These results , together with our previous study and others , suggest that MK2 , in HPMECs , regulates *induced* expression of [ICAM-1] and IL-8 via TTP at the mRNA decay level . Positive_regulation ICAM1 TNF 22280832 2564968 Pretreatment of VSMCs with ohioensin F at nontoxic concentrations of 0.1-10 µg/ml dose-dependently inhibited *induced* expression of vascular cell adhesion molecule-1 ( VCAM-1 ) and [intercellular adhesion molecule-1] ( ICAM-1 ) . Positive_regulation ICAM1 TNF 22427561 2588216 Glucosamine modulates *induced* [ICAM-1] expression and function through O-linked and N-linked glycosylation in human retinal pigment epithelial cells . Positive_regulation ICAM1 TNF 22427561 2588217 The purpose of this article was to investigate the effects of glucosamine ( GlcN ) on the *induced* expression of [intercellular adhesion molecule 1] ( ICAM-1 ) and the function of ICAM-1 in ARPE-19 cells in vitro . Positive_regulation ICAM1 TNF 22427561 2588218 We quantified protein levels of *induced* [ICAM-1] in ARPE-19 cells with Western blotting . Positive_regulation ICAM1 TNF 22427561 2588220 GlcN , PUGNAc , and OGT overexpression inhibited *induced* [ICAM-1] expression and NF-?B activity in ARPE-19 cells . Positive_regulation ICAM1 TNF 22427561 2588221 GlcN and tunicamycin reduced the molecular mass of *induced* [ICAM-1] in ARPE-19 cells . Positive_regulation ICAM1 TNF 22427561 2588222 The proteasome inhibitor MG-132 suppressed the GlcN induced reduction in the molecular mass of *induced* [ICAM-1] . Positive_regulation ICAM1 TNF 22427561 2588223 GlcN also attenuated the adhesion activity of *induced* [ICAM-1] . Positive_regulation ICAM1 TNF 22427561 2588224 GlcN inhibits ICAM-1 expression and functions by modulating the O-linked glycosylation of factors involved in NF-?B signaling and by reducing the N-linked glycosylation of *induced* [ICAM-1] in ARPE-19 cells . Positive_regulation ICAM1 TNF 22465119 2583190 Finally , potently *induced* [ICAM-1] and VCAM-1 expression in both SV-EC and SV-SMC . Positive_regulation ICAM1 TNF 22526394 2595908 also *increased* the production of inducible nitric oxide synthase (iNOS) , nitric oxide ( NO ) , and [intercellular adhesion molecule 1] ( ICAM-1 ) through activation of p38 mitogen activated protein kinase (MAPK) from HT-29 cells . Positive_regulation ICAM1 TNF 22536886 2686597 strongly *increased* the expression of VCAM-1 and [ICAM-1] accompanied by increased expression of p-i?B and NF-?B proteins . Positive_regulation ICAM1 TNF 22609006 2632294 Keap1 knockdown inhibited *induced* expression of intracellular adhesion molecule-1 ( [ICAM-1] ) and vascular cell adhesion molecule-1 ( VCAM-1 ) by suppressing NF-?B activation via inhibition of its upstream modulators , Akt , NIK , and IKK , resulting in the elevation of monocyte adhesion to endothelial cells . Positive_regulation ICAM1 TNF 22609186 2609751 Moreover , *induced* [ICAM-1] expression on the cell surface was reduced in cells with suppressed PKN3 expression . Positive_regulation ICAM1 TNF 22661092 2615445 RXR agonists also prevented *induced* VCAM-1 and [ICAM-1] expression , as well as endothelial growth related oncogene-a and MCP-1 release . Positive_regulation ICAM1 TNF 22708120 2616094 Quantitative reverse transcriptase PCR and Western blot analyses indicated that IL-33 mediates the expression of [intercellular adhesion molecule (ICAM)-1] and vascular cell adhesion molecule (VCAM)-1 in endothelial cells basally and in *response* to . Positive_regulation ICAM1 TNF 22751795 2676265 Flavonoid extract was effective in inhibiting expression of [intercellular adhesion molecule-1] ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ) *induced* by in HUVECs . Positive_regulation ICAM1 TNF 22762513 2639487 Dao-Tan decoction inhibits *induced* [intercellular adhesion molecule-1] expression by blocking JNK and p38 signaling pathways in human umbilical vein endothelial cells . Positive_regulation ICAM1 TNF 22762513 2639489 Previous study shows that DTD could inhibit [intercellular adhesion molecule-1] ( ICAM-1 ) expression *induced* by . Positive_regulation ICAM1 TNF 22762513 2639491 To examine the hypothesis that DTD might inhibit *induced* [ICAM-1] expression through regulating the mitogen activated protein kinase (MAPK) pathways , involving Jun N-terminal kinase (JNK) and p38 . Positive_regulation ICAM1 TNF 22762513 2639492 DTD serum significantly inhibits *induced* [ICAM-1] expression by 17-41 % on HUVECs . Positive_regulation ICAM1 TNF 22821773 2682268 According to Western blot analysis and a luciferase activity assay , anthocyanins inhibited *induced* [intercellular adhesion molecule-1] and cyclooxygenase-2 (COX-2) levels through the NF-?B dependent pathway . Positive_regulation ICAM1 TNF 22842465 2646575 Our data showed that omentin decreased *induced* expression of [ICAM-1] and VCAM-1 in HUVECs . Positive_regulation ICAM1 TNF 22842465 2646581 Omentin , NF-kB inhibitor ( BAY11-7082 ) and ERK inhibitor ( PD98059 ) reduced the up-regulation of [ICAM-1] and VCAM-1 *induced* by . Positive_regulation ICAM1 TNF 22862554 2641076 Stimulation of a human bronchial epithelial cell line ( BEAS-2B ) with *increased* the expression of surface adhesion molecules , including [intercellular adhesion molecule 1] ( ICAM-1 ) and vascular cell adhesion molecule 1 ( VCAM-1 ) , in which eupatilin significantly inhibited the expression of those adhesion molecules in a dose dependent manner . Positive_regulation ICAM1 TNF 22981364 2693621 In addition , Jap A suppressed *induced* expressions of adhesion molecules ( [ICAM-1] , VCAM-1 ) and chemokine ( MCP-1 ) in the endothelial cells by blocking TNF-a triggered multiple signaling pathways . Positive_regulation ICAM1 TNF 22998024 2694263 These findings suggest that iNOS derived NO increases TNF-a levels in the middle and distal colon and increased levels *induce* expression of P-selectin and [ICAM-1] , thereby promoting the infiltration of activated neutrophils , which leads to damage to colonic tissue . Positive_regulation ICAM1 TNF 23006728 2689247 Here , we found that reduction of [ Cl ( - ) ] ( i ) increased *induced* expression of [intercellular adhesion molecule 1] and vascular cell adhesion molecule 1 and adhesion of monocytes to endothelial cells ( P < 0.05 ; n=6 ) . Positive_regulation ICAM1 TNF 23035855 2716431 In addition , the effects of total flavonoids on inflammatory molecule expression of cells were tested by immunohistochemistry staining , showing that *induced* expression of PCNA , NF-?B p65 , [ICAM-1] , and VCAM-1 in VSMCs was dose-dependently suppressed by total flavonoids . Positive_regulation ICAM1 TNF 23049757 2684882 ß2-Agonists inhibit *induced* [ICAM-1] expression in human airway parasympathetic neurons . Positive_regulation ICAM1 TNF 23049757 2684883 To test whether the ß ( 2 ) agonist albuterol , which is used to treat asthma , changes *induced* eotaxin and [ICAM-1] expression in human parasympathetic neurons . Positive_regulation ICAM1 TNF 23049757 2684885 The ß-receptor antagonist propranolol blocked the inhibitory effect of ( R ) -albuterol on *induced* [ICAM-1] expression . Positive_regulation ICAM1 TNF 23052181 2698630 RNH-6270 suppressed cell death and the increase in [ICAM-1] expression *induced* by via the inhibition of reactive oxygen species in HGECs . Positive_regulation ICAM1 TNF 23085565 2703488 Tanshinone IIA inhibits mediated *induction* of VCAM-1 but not [ICAM-1] through the regulation of GATA-6 and IRF-1 . Positive_regulation ICAM1 TNF 23085565 2703490 The goal of this study was to investigate the differential effect of tanshinone IIA on the *induction* of [intercellular adhesion molecule-1] ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) by and the possible molecular mechanisms by which it regulates ICAM-1 and VCAM-1 expression differentially . Positive_regulation ICAM1 TNF 23085565 2703496 Stimulation of human umbilical vein endothelial cells ( HUVEC ) with *increased* [ICAM-1] and VCAM-1 expressions , and the pretreatment with tanshinone IIA concentration dependently inhibited VCAM-1 expression but not ICAM-1 expression . Positive_regulation ICAM1 TNF 23085565 2703498 In previous study , PI3K/Akt , PKC and Jak/STAT-3 pathways were involved in the mediated *induction* of VCAM-1 but not [ICAM-1] . Positive_regulation ICAM1 TNF 23085565 2703511 Taken together , tanshinone IIA selectively inhibits *mediated* expression of VCAM-1 but not [ICAM-1] through modulation of PI3/Akt , PKC and Jak/STAT-3 pathway as well as IRF-1 and GATA-6 binding activity . Positive_regulation ICAM1 TNF 23243449 2708708 In addition , these inhibitors reversed the suppressive effect of KGBE on mediated *induction* of [ICAM-1] and VCAM-1 , resulting in decreased interaction between endothelial cells and monocytes . Positive_regulation ICAM1 TNF 23247124 2718623 Interleukin 10 decreases the level of inflammation induced by TNF-a in endothelial cells by reducing the *induced* ROS production , [ICAM-1] expression , and leukocyte adhesion to the endothelium . Positive_regulation ICAM1 TNF 23299081 2737879 Both IFN-a and IFN-ß strongly reduced the production of IL-12p40 , IL-1ß and and the IFN-? *induced* [CD54] and CD64 expression . Positive_regulation ICAM1 TNF 23357557 2747719 In human lung carcinoma A549 cells , deoxynivalenol and 3-acetyldeoxynivalenol inhibited the expression of [intercellular adhesion molecule-1] ( ICAM-1 ) *induced* by more strongly than that induced by interleukin 1a (IL-1a) , whereas T-2 toxin and verrucarin A exerted nonselective inhibitory effects . Positive_regulation ICAM1 TNF 23357557 2747720 In addition to the TACE inhibitor TAPI-2 , the MAP kinase or extracellular signal regulated kinase ( ERK ) kinase ( MEK ) inhibitor U0126 and the p38 MAP kinase inhibitor SB203580 , but not the c-Jun N-terminal kinase (JNK) inhibitor SP600125 , suppressed the ectodomain shedding of TNF receptor 1 induced by deoxynivalenol and reversed its selective inhibition of *induced* [ICAM-1] expression . Positive_regulation ICAM1 TNF 23364439 2754531 Despite this basal activation , hyperosmolar incubation attenuated *stimulated* IL-8 release and [ICAM-1] surface expression and subsequent PMN adherence , while p38 MAPK inhibition did not further influence the effects of hyperosmolar conditions on ICAM-1 surface expression . Positive_regulation ICAM1 TNF 23462755 2760703 *induced* [intercellular adhesion molecule-1] ( ICAM-1 ) and endothelial nitric oxide synthase (eNOS) phosphorylation were measured with and without ROCK inhibition by fasudil or ROCK-specific small interfering RNA ( siRNA ) . Positive_regulation ICAM1 TNF 23462755 2760706 *induced* [ICAM-1] expression , eNOS dephosphorylation , cytoskeletal changes , and CD11b/18 expression in neutrophils were significantly suppressed by fasudil as well as ROCK-specific siRNA . Positive_regulation ICAM1 TNF 23608189 2795237 To elucidate the molecular mechanisms involved in these effects , we investigated the effect of statins on *induced* ROS production , vascular cell adhesion molecule-1 ( VCAM-1 ) and [intercellular adhesion molecule-1] ( ICAM-1 ) expression in human aortic endothelial cells ( HAECs ) . Positive_regulation ICAM1 TNF 23608189 2795240 The Rac-1 activation and ROS liberation mediated *stimulated* NF-?B activation and the subsequent VCAM-1 and [ICAM-1] expression . Positive_regulation ICAM1 TNF 23608189 2795243 In addition , pretreatment with atorvastatin inhibited *induced* ROS production and VCAM-1 and [ICAM-1] expression . Positive_regulation ICAM1 TNF 23608189 2795246 Chemical or genetic inhibition of ERK5 ablated the statins inhibition of Rac-1 activation , ROS formation , NF-?B , VCAM-1 and [ICAM-1] expression *induced* by . Positive_regulation ICAM1 TNF 23619991 2790357 Remarkably , the treatment of the HESCs with HEABG potently suppressed the *induced* [ICAM-1] and VCAM-1 transcript and protein expression by inhibiting the activation of NF-?B and AP-1 transcription factors . Positive_regulation ICAM1 TNF 23627472 2800364 Depending on concentration , the extract exerted scavenging activity on DPPH radical ( EC50 7.09 mg/mL ) , significantly inhibited *induced* [ICAM-1] expression by 55-58.8 % on human umbilical vein endothelial cells at 100 and 200 µg/mL , but failed to reduce egg-white induced rat paw edema . Positive_regulation ICAM1 TNF 23632129 2790689 Largazole , a class I histone deacetylase inhibitor , enhances *induced* [ICAM-1] and VCAM-1 expression in rheumatoid arthritis synovial fibroblasts . Positive_regulation ICAM1 TNF 23632129 2790698 In the present study , we evaluated the effect of largazole (LAR) , a marine derived class I HDAC inhibitor , on *induced* expression of [intercellular adhesion molecule-1] ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) , and matrix metalloproteinase-2 (MMP-2) activity . Positive_regulation ICAM1 TNF 23632129 2790714 Pretreatment of RA synovial fibroblasts with LAR further enhanced *induced* [ICAM-1] and VCAM-1 expression . Positive_regulation ICAM1 TNF 23632129 2790722 Further , the addition of HDAC6 specific inhibitor Tubastatin A with LAR suppressed *induced* [ICAM-1] and VCAM-1 expression and completely blocked MMP-2 activity , suggesting a role of HDAC6 in LAR induced ICAM-1 and VCAM-1 expression . Positive_regulation ICAM1 TNF 23676335 2838398 NaHS also inhibited *induced* [ICAM-1] protein expression , which was similar to the effect of antioxidant N-acetyl-L-cysteine . Positive_regulation ICAM1 TNF 23728723 2819778 ( 1-80 ng/mL ) *caused* dose- and time dependent increases of [ICAM-1] and VCAM-1 expression in HUVECs , accompanied by significant augmentation of I?B phosphorylation and NF-?B translocation into the nuclei . Positive_regulation ICAM1 TNF 23751820 2895582 Autophagy , but not p53 , also modulated *induced* NF-?B activation and [ICAM-1] expression . Positive_regulation ICAM1 TNF 23751820 2895584 These results demonstrated that IFN-? and *induced* [ICAM-1] expression through a common pathway that was regulated by autophagy , but not p53 . Positive_regulation ICAM1 TNF 23800055 2802861 Furthermore , PF markedly blocked *induced* E-selectin and [intercellular adhesion molecule-1] ( ICAM-1 ) expression in HDMECs at both mRNA and protein levels . Positive_regulation ICAM1 TNF 23892569 2839561 Glucocorticoid induced receptor family related ligand triggering *upregulates* vascular cell adhesion molecule-1 and [intercellular adhesion molecule-1] and promotes leukocyte adhesion . Positive_regulation ICAM1 TNF 23977989 2833005 Curcumin ameliorates *induced* [ICAM-1] expression and subsequent THP-1 adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells . Positive_regulation ICAM1 TNF 23977989 2833006 Furthermore , Nrf2 knockdown using siRNA reversed the inhibitory effect of curcumin on the *induced* [ICAM-1] expression and adhesion of monocytes to keratinocytes . Positive_regulation ICAM1 TNF 23977989 2833007 These results suggest that curcumin may exert its anti-inflammatory activity by suppressing the *induced* [ICAM-1] expression and subsequent monocyte adhesion via expression of HO-1 in the keratinocytes . Positive_regulation ICAM1 TNF 24006483 2856237 Human Jurkat T-cells lacking CD47 also showed reduced adhesion to *activated* endothelium and [ICAM-1] and VCAM-1 . Positive_regulation ICAM1 TNF 24134657 2889348 MPA significantly inhibits *induced* [ICAM-1] , VCAM-1 surface protein and mRNA expression as well as adhesion of mononuclear leukocytes to HAEC . Positive_regulation ICAM1 TNF 24134657 2889350 *increased* [ICAM-1] and VCAM-1 expression via c-Jun NH2 -terminal kinase (JNK) , extracellular signal regulated kinase ( ERK1/2 ) and p38 MAPK . Positive_regulation ICAM1 TNF 24211395 2891821 Furthermore , AS suppressed *induced* activity and expression of matrix metalloproteinase-9 (MMP-9) , and cell-surface expression of [intercellular adhesion molecule-1] ( ICAM-1 ) , which was associated with abridged adhesion of U937 leukocytes to endothelial cells . Positive_regulation ICAM1 TNF 24329519 2921477 Monitoring of *induced* expression of the adhesion molecules VCAM-1 , [ICAM-1] and E-selectin by flow cytometry was used to confirm NF-?B inhibition in endothelial cells , and thioglycollate induced peritonitis in mice to confirm effects in vivo . Positive_regulation ICAM1 TNF 24329519 2921479 Plumericin inhibited NF-?B mediated transactivation of a luciferase reporter gene ( IC50 1 µM ) , abolished *induced* expression of the adhesion molecules VCAM-1 , [ICAM-1] and E-selectin in endothelial cells and suppressed thioglycollate induced peritonitis in mice . Positive_regulation ICAM1 TNF 24333549 2910826 Our results showed that tumor necrosis factor-alpha ( TNF-a ) significantly increased the protein or mRNA levels of monocyte chemotactic protein-1 (MCP-1) , intercellular adhesion molecule-1 ( ICAM-1 ) , and vascular cell adhesion molecule-1 ( VCAM-1 ) , whereas pretreatment with Malvidin inhibited *induced* increases of MCP-1 , [ICAM-1] , and VCAM-1 production in a concentration dependent manner . Positive_regulation ICAM1 TNF 24333719 2910828 released from LPS treated monocytes *triggered* the expression of intercellular cell adhesion molecule-1 ( [ICAM-1] ) and vascular cell adhesion molecule-1 ( VCAM-1 ) on endothelial cells . Positive_regulation ICAM1 TNF 24355235 2881420 The results showed that the up-regulation of [ICAM-1] and VCAM-1 *induced* by was dose-dependently inhibited by Tanshinone VI , with restoration of control levels at the dose of 40 mM ; Positive_regulation ICAM1 TNF 24502696 2914075 *induces* matrix metalloproteinase-9 dependent soluble [intercellular adhesion molecule-1] release via TRAF2 mediated MAPKs and NF-?B activation in osteoblast-like MC3T3-E1 cells . Positive_regulation ICAM1 TNF 24502696 2914077 We applied gelatin zymography , Western blot , RT-PCR , real-time PCR , selective pharmacological inhibitors of transcription ( actinomycin D , Act.D ) , translation ( cycloheximide , CHI ) , c-Src ( PP1 ) , MEK1/2 ( U0126 ) , p38 MAPK ( SB202190 ) , JNK1/2 ( SP600125 ) , and NF-?B ( Bay11-7082 ) , respective siRNAs transfection , promoter assay , immunofluorescence staining , and ELISA to investigate the MMP-9 expression and soluble [ICAM-1] ( sICAM-1 ) release *induced* by in MC3T3-E1 cells . Positive_regulation ICAM1 TNF 24940033 2942146 *induced* [ICAM-1] expression and monocyte adhesion in human RPE cells is mediated in part through autocrine VEGF stimulation . Positive_regulation ICAM1 TNF 24940033 2942147 *upregulates* [intercellular adhesion molecule (ICAM)-1] expression on the RPE , which allows lymphocyte function associated antigen-1 ( LFA-1 ) to bind on leukocytes that contribute to leukocyte adhesion at sites of inflammation . Positive_regulation ICAM1 TNF 24940033 2942148 Therefore , we tested the hypothesis that VEGF-A(165)b regulates *induced* [ICAM-1] expression and monocyte adhesion in RPE cells . Positive_regulation ICAM1 TNF 24940033 2942152 VEGF-A(165)b and ZM323881 inhibited *induced* upregulation of [ICAM-1] in RPE cells . Positive_regulation ICAM1 TNF 24940033 2942154 These findings indicate that VEGF-A(165)b inhibits *mediated* upregulation of [ICAM-1] expression and increases monocyte-RPE cell adhesion , suggesting an anti-inflammatory property of VEGF-A(165)b in the eye . Positive_regulation ICAM1 TNF 2497153 109738 also *induced* keratinocyte [ICAM-1] expression ( although to a lesser degree than IFN-gamma ) but did not induce either keratinocyte HLA-DR or DQ expression . Positive_regulation ICAM1 TNF 2506138 117116 *enhanced* the expression of [ICAM-I] on all the melanoma cell lines , although to a lower extent than IFN-gamma and the combination of IFN-gamma and TNF-alpha . Positive_regulation ICAM1 TNF 25379003 2960127 In addition , REKRG markedly inhibited the mediated *induction* of [intercellular adhesion molecule (ICAM)-1] and cyclooxygenase (COX)-2 expressions in endothelial cells . Positive_regulation ICAM1 TNF 3137261 95931 The expression of [intercellular adhesion molecule-1] ( ICAM-1 ) on primary human fibroblasts , a human fibrosarcoma , chondrosarcoma , and adenocarcinoma cell line in *response* to IL-1 , , or IFN-gamma was studied using an ELISA with anti-ICAM-1 mAb . Positive_regulation ICAM1 TNF 7506926 240017 In cultured follicles , dose dependent *induction* of HLA class I , DR and [ICAM-1] by IFN-gamma , and HLA class I and ICAM-1 , but not HLA-DR , by was observed in follicular epithelium , mainly in the outer root sheath ( ORS ) . Positive_regulation ICAM1 TNF 7507414 244559 The addition of interferon-gamma delays the time at which peak expression of [ICAM-1] in *response* to stimulation occurs . Positive_regulation ICAM1 TNF 7511974 250203 alone *induced* only HLA class I and [ICAM-1] , but not HLA class II or LFA-1 alpha . Positive_regulation ICAM1 TNF 7516017 257423 In ELISA analysis , [ICAM-1] molecule expression on myocytes was significantly *stimulated* by ( 100 U/ml ) , but not by IL-6 ( 100 U/ml ) or IL-8 ( 100 ng/ml ) dose dependently . Positive_regulation ICAM1 TNF 7517980 261805 Thus , UVB selectively upregulates [ICAM-1] , but not E-selectin or VCAM-1 , mRNA and cell surface expression in HDMEC , and this upregulation is not *dependent* upon the autologous secretion and activity of either IL-1 or . Positive_regulation ICAM1 TNF 7523771 243733 Inflammatory mediators likely to occur under those conditions , e.g. , histamine , thrombin , oxygen derived free radicals (ODFR) , interleukin (IL)-1 , , and activated complement factors , *induce* in a distinct time course the ( transient ) expression of the leukocyte adhesion molecules P-selectin , E-selectin , [intercellular adhesion molecule (ICAM)-1] , and vascular cell adhesion molecule (VCAM)-1 on the endothelium . Positive_regulation ICAM1 TNF 7526034 277066 We also examined the *mediated* upregulation of E-selectin , vascular cell adhesion molecule-1 and [intercellular adhesion molecule-1] . Positive_regulation ICAM1 TNF 7532274 286179 Cellular expression of [ICAM-1] was drastically *induced* by or interleukin-1 stimulation , and the moderate expression with delayed-action was observed only by lipopolysaccharide stimulation . Positive_regulation ICAM1 TNF 7532667 292151 Activation of cAMP dependent pathways in human airway smooth muscle cells inhibits *induced* [ICAM-1] and VCAM-1 expression and T lymphocyte adhesion . Positive_regulation ICAM1 TNF 7532667 292153 In this study , we examined whether an increase in [ cAMP ] i , presumably via activation of cAMP dependent protein kinase , modulates *induced* [ICAM-1] and VCAM-1 on ASM . Positive_regulation ICAM1 TNF 7532667 292159 In addition , treatment with either isoproterenol or prostaglandin E2 , which activates receptors coupled to Gs and increases [ cAMP ] i , also inhibited *induced* expression of [ICAM-1] and VCAM-1 on ASM . Positive_regulation ICAM1 TNF 7536438 297256 *induced* endothelial E-selectin , [intercellular adhesion molecule-1] ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) in all groups , and adhesion molecule expression by interstitial dermal dendritic cells ( ICAM-1 and VCAM-1 ) and keratinocytes ( ICAM-1 ) was observed . Positive_regulation ICAM1 TNF 7543521 314316 Enhancement by the complement membrane attack complex of *induced* endothelial cell expression of E-selectin and [ICAM-1] . Positive_regulation ICAM1 TNF 7543521 314318 This conclusion was further supported by a whole-cell ELISA , which provided evidence that the MAC augments induced *up-regulation* of both E-selectin and [ICAM-1] . Positive_regulation ICAM1 TNF 7545397 318536 PD 144795 treatment markedly inhibited the *induced* cell expression of vascular cell adhesion molecule-1 ( VCAM-1 ) and [intercellular adhesion molecule-1] ( ICAM-1 ) protein and mRNA . Positive_regulation ICAM1 TNF 7545567 318589 IFN-gamma stimulation induced surface human leukocyte antigen ( HLA ) -DR in both SVRPE and HRPE , while treatment *induced* surface expression of [intercellular adhesion molecule (ICAM)-1] on SVRPE and upregulated ICAM from basal levels on HRPE . Positive_regulation ICAM1 TNF 7556450 327675 The tsT-SScF cells also retained their responsiveness to cytokines , since interferon-gamma (IFN-gamma) and both produced a marked *increase* in [ICAM-1] expression . Positive_regulation ICAM1 TNF 7578984 333395 The current study was undertaken to investigate the *role* of in regulation of E-selectin and [ICAM-1] expression by TNF on HUVEC . Positive_regulation ICAM1 TNF 7578984 333400 In contrast , both MR2-1 and pAb75 inhibited specifically *induced* E-selectin and [ICAM-1] expression , but not activation by IL-1 or LPS . Positive_regulation ICAM1 TNF 7583580 333556 HDLs had no effect on *induced* expression of [ICAM-1] by human foreskin fibroblasts , suggesting that the effect is cell-type restricted . Positive_regulation ICAM1 TNF 7598530 311316 Recombinant and rTNF-beta markedly reduced the expression of the pigment cell associated antigens HMB-45 and K.1.2 , and they *enhanced* the expression of VLA-2 , [ICAM-1] and HLA class I antigens and strongly induced HLA-DR. Similar changes were induced by rIL-1a , rIL-b and rIL-6 , and rIL-2 decreased the expression of HLA class I antigens and of ICAM-1 . Positive_regulation ICAM1 TNF 7616001 315201 Suprabasal [ICAM-1] can be *induced* by UVR and epidermal release , and by factors such as viral infection . Positive_regulation ICAM1 TNF 7636209 317418 *Up-regulation* of lung vascular [ICAM-1] by intratracheally administered was also prevented by complement depletion . Positive_regulation ICAM1 TNF 7642556 317980 H2O2 and *activate* [intercellular adhesion molecule 1] ( ICAM-1 ) gene transcription through distinct cis-regulatory elements within the ICAM-1 promoter . Positive_regulation ICAM1 TNF 7642556 317982 In contrast , *induced* [ICAM-1] transcription via activation of promoter sequences between -393 and -176 , a region with C/EBP and NF-kappa B binding sites . Positive_regulation ICAM1 TNF 7642556 317983 The results indicate that H2O2 activates ICAM-1 transcription through AP-1/Ets elements within the ICAM-1 promoter , which are distinct from NF-kappa B-mediated [ICAM-1] expression *induced* by . Positive_regulation ICAM1 TNF 7684420 217585 Elevated cyclic AMP inhibits endothelial cell synthesis and expression of *induced* endothelial leukocyte adhesion molecule-1 , and vascular cell adhesion molecule-1 , but not [intercellular adhesion molecule-1] . Positive_regulation ICAM1 TNF 7684420 217588 Unexpectedly , this combination of cAMP elevating drugs inhibits *induction* of ELAM-1 and VCAM-1 but not [ICAM-1] expression . Positive_regulation ICAM1 TNF 7685152 219707 In both rat pulmonary artery endothelial cells and human umbilical vein endothelial cells , *induced* an early ( within 60 minutes ) increase in [ICAM-1] expression , followed by a peak at 6 to 8 hours , with relatively stable expression at 24 hours . Positive_regulation ICAM1 TNF 7686194 222117 [ICAM-1] , but not LFA-3 , was rapidly *up-regulated* by interleukin-1 (IL-1) , , and to some extent by interferon-gamma (IFN) and IL-6 , whereas IL-4 had variable low effects , if any . Positive_regulation ICAM1 TNF 7693806 234204 *increases* the expression of [ICAM-1] , but not ICAM-2 , and induces the expression of ELAM-1 on both EC types . Positive_regulation ICAM1 TNF 7693807 234214 [ICAM-1] is constitutively expressed on the endothelioma surface and expression is *increased* by , IL-1 , LPS , and IFN-gamma . Positive_regulation ICAM1 TNF 7693807 234226 Furthermore , although , preincubation of bEND.3 cells with IFN-gamma modestly increases the induction of [ICAM-1] and VCAM-1 in *response* to and IL-1 , it dramatically reduces the TNF-alpha , IL-1 , and LPS induced expression of MAdCAM-1 . Positive_regulation ICAM1 TNF 7706764 297856 The level of [ICAM-1] expression in *response* to and ultraviolet radiation ( UVR ) in individual strains was highly correlated in three different comparisons : level of stimulated response versus baseline ( TNF-alpha and UVR both p < 0.0001 ) ; Positive_regulation ICAM1 TNF 7706764 297858 The release of from keratinocytes by UVR and the individually variable but linked characteristics of UVR and TNF-alpha *stimulated* [ICAM-1] expression support the hypothesis that TNF-alpha is a major mediator of UVR induced ICAM-1 expression . Positive_regulation ICAM1 TNF 7729535 302158 Up-regulation of [ICAM-1] expression on human dermal fibroblasts by IFN-beta in the *presence* of . Positive_regulation ICAM1 TNF 7738362 305686 However , as determined by flow cytometry , pentoxifylline did not alter induced *upregulation* of [intercellular adhesion molecule-1] or vascular cellular adhesion molecule-1 on endothelioma cells nor did it affect constitutive CD11a , CD18 , or alpha 4-integrin expression on T-lymphoma cells , suggesting that rather than affecting quantitative expression of these adhesion molecules , pentoxifylline might modulate their avidity . Positive_regulation ICAM1 TNF 7780030 309417 Conversely , , in the same conditions , strongly *stimulated* membrane [ICAM-1] expression and the shedding of the soluble form . Positive_regulation ICAM1 TNF 7783951 309757 Stimulation of confluent monolayers of adult human cerebral endothelial cells with lipopolysaccharide (LPS) or recombinant human could *induce* expression and secretion of soluble [ICAM-1] in a dose dependent manner . Positive_regulation ICAM1 TNF 7798616 281103 however , pyrrolidine dithiocarbamate and alpha-tocopherol had no effect on either IFN-gamma- or *induced* [ICAM-1] mRNA levels . Positive_regulation ICAM1 TNF 7802927 284573 *Induction* of [ICAM-1] by IFN gamma or on keratinocytes that do not express this molecule in normal skin may account for the recruitment of T cells into the epidermis . Positive_regulation ICAM1 TNF 7813562 285219 [ICAM-1] expression on the surface of human umbilical vein endothelial cells was *increased* significantly by stimulation with interleukin-1 beta , , thrombin and platelet activating factor (PAF) . Positive_regulation ICAM1 TNF 7822333 293057 Previously , we had shown that the [ICAM-1] gene expression in human umbilical vein endothelial cells ( HUVECs ) was transcriptionally *regulated* by ( Wertheimer , S. J. , Myers , C. L. , Wallace , R. W. , and Parks , T. P. ( 1992 ) J. Biol. Chem. 267 , 12030-12035 ) . Positive_regulation ICAM1 TNF 7880619 289080 Interleukin 1 (IL-1) , and IFN gamma *increased* the cell surface expression of [ICAM-1] and caused the release of soluble ICAM-1 from HOC cells established in vitro . Positive_regulation ICAM1 TNF 7902093 234544 To examine the regulation of the [intercellular adhesion molecule 1] ( ICAM-1 ) gene in cultured human synovial fibroblasts in *response* to , and investigate its modulation by the synthetic glucocorticoid , dexamethasone . Positive_regulation ICAM1 TNF 7902093 234546 In addition , dexamethasone inhibited *induced* surface expression of [ICAM-1] , accumulation of ICAM-1 mRNA , and adhesion of monocytes to TNF alpha activated synovial fibroblasts . Positive_regulation ICAM1 TNF 7906155 240346 or IL-1 treatment of HUVE potently *induced* surface [ICAM-1] expression , whereas these cytokines were relatively ineffective on HLE and HSE ICAM-1 expression . Positive_regulation ICAM1 TNF 7910170 254301 is the most potent *inducer* of [ICAM-1] expression , followed by IL-1 beta , then IFN-gamma . Positive_regulation ICAM1 TNF 7910170 254302 Nuclear run-on analysis demonstrated that the ICAM-1 gene is transcribed under basal conditions in astrocytes , and that both and IL-1 beta *enhance* transcriptional activation of the [ICAM-1] gene . Positive_regulation ICAM1 TNF 7911491 257847 These data demonstrate that both TNF and ICAM-1 participate in lymphocyte activation and granuloma formation and suggest that one mechanism of TNF in granuloma development is through *induced* [ICAM-1] expression . Positive_regulation ICAM1 TNF 7915264 269699 Transfection induced *increases* the susceptibility of human glioma cells to lysis by lymphokine activated killer cells : continuous expression of [intercellular adhesion molecule-1] on the glioma cells . Positive_regulation ICAM1 TNF 7915264 269700 We compared the expression of [ICAM-1] *induced* by generated by the TNF-alpha gene transfected cells with that induced by exogenously added TNF-alpha . Positive_regulation ICAM1 TNF 7915999 269785 IL-1 beta and *induced* a parallel increase of both the [ICAM-1] expression on EC and sICAM-1 production by EC , while IFN-gamma induced only the dose dependent enhancement of ICAM-1 expression , but not the production of sICAM-1 , IL-4 and IL-6 did not show any effects on the ICAM-1 expression nor on the sICAM-1 production . Positive_regulation ICAM1 TNF 7918844 272421 Stimulation with or interferon-gamma ( 100 kU/l ) *led* to a significant induction of [ICAM-1] on the surface of control alveolar macrophages ( 0.76 EU +/- 0.18 , p < 0.005 for TNF-alpha , 0.64 EU +/- 0.10 , p < 0.005 for interferon-gamma ) , whereas alveolar macrophages from both patient groups did not respond to cytokines even at high dosages . Positive_regulation ICAM1 TNF 7940740 276251 Finally , constitutive ICAM-1 expression was related to *induced* [ICAM-1] levels based upon a subset of the isolates studied . Positive_regulation ICAM1 TNF 7945915 276577 Both the normal and systemic sclerosis dermal fibroblasts increased their cell surface expression of [ICAM-1] in *response* to interleukin-1 beta (IL-1 beta) , , and interferon-gamma (IFN-gamma) in a dose dependent fashion . Positive_regulation ICAM1 TNF 7955542 277809 significantly *induced* [ICAM-1] expression on these cells . Positive_regulation ICAM1 TNF 7957579 278073 IL-10 potently inhibits the *induced* [ICAM-1] up-regulation , but not the IFN-gamma induced H-2K up-regulation . Positive_regulation ICAM1 TNF 7957928 278120 Synergistic *activation* of [intercellular adhesion molecule 1] ( ICAM-1 ) by and IFN-gamma is mediated by p65/p50 and p65/c-Rel and interferon-responsive factor Stat1 alpha ( p91 ) that can be activated by both IFN-gamma and IFN-alpha . Positive_regulation ICAM1 TNF 7957928 278130 Human [ICAM-1] expression is *up-regulated* by IFN-gamma and and synergistically increased by a combination of both . Positive_regulation ICAM1 TNF 8039251 266609 or interferon-gamma *increased* the expression of [ICAM-1] on choriocarcinoma cells without modifying the adhesion of lymphocytes to choriocarcinoma cells . Positive_regulation ICAM1 TNF 8082888 271077 The *upregulation* of [ICAM-1] by IL-1 alpha , , and IFN-gamma appeared similar , whereas the induction of VCAM-1 by IL-1 alpha , IL-4 , TNF-alpha , and IFN-gamma showed differences between the three cell types . Positive_regulation ICAM1 TNF 8093640 210077 Furthermore , in U-87 cells , *enhanced* both [ICAM-1] and interleukin-1 beta (IL-1 beta) expression , and decreased immunoreactivity for transforming growth factor-beta ( TGF-beta ) protein . Positive_regulation ICAM1 TNF 8095156 211877 *stimulates* [ICAM-1] expression in human vascular smooth muscle cells . Positive_regulation ICAM1 TNF 8095156 211883 In the presence of anti-ICAM-1 monoclonal antibody 10F3 , monocyte adhesion to TNF-alpha pretreated SMCs was significantly inhibited , suggesting that the observed monocyte-SMC interaction involved the [ICAM-1] expressed on SMC surfaces as a *result* of stimulation . Positive_regulation ICAM1 TNF 8095960 214508 Accordingly , unstimulated eosinophils did not express significant amounts of ICAM-1 mRNA , but [ICAM-1] mRNA expression could be markedly induced in these cells upon *stimulation* with IFN gamma plus . Positive_regulation ICAM1 TNF 8096220 214554 We have recently reported that levels of tumor necrosis factor-alpha (TNF-alpha) correlate with blood-brain barrier damage in patients with active MS. Stimulation of endothelial cells by *induces* the expression of [intercellular adhesion molecule-1] ( ICAM-1 ) , which is an important early marker of immune activation and response . Positive_regulation ICAM1 TNF 8096222 214555 TGF beta had no effect on the up-regulation of [ICAM-1] expression *induced* by IFN-gamma , IL-1 alpha and/or . Positive_regulation ICAM1 TNF 8097205 214642 The expression of [ICAM-1] in myocardial cells could be *induced* in vitro by IFN-gamma and , which were shown to be synthesized by the infiltrating cells . Positive_regulation ICAM1 TNF 8097520 217651 and IL-1 beta also *increased* the expression of [ICAM-1] on MMG2 . Positive_regulation ICAM1 TNF 8098585 217720 At 24 hours , and hydrogen peroxide produce , at most , additive *increases* in [intercellular adhesion molecule-1] and major histocompatibility complex class I . Positive_regulation ICAM1 TNF 8099361 219991 IL-1 beta , and IFN gamma *potentiated* [ICAM-1] expression in both cell lines in a dose related manner . Positive_regulation ICAM1 TNF 8099939 220114 Given our recent observation that DS thymuses overexpress mRNA for IFN-gamma and TNF , and the fact that both of these cytokines induce ICAM-1 expression on cultured human thymic epithelial cells , we propose that increased levels of IFN-gamma and *contribute* to the enhanced expression of [ICAM-1] in DS thymuses . Positive_regulation ICAM1 TNF 8100455 222532 Exposure of HUVEC to perflubron did not alter the upregulation of [ICAM] or ELAM in *response* to IL-1 or ( n = 20 ) . Positive_regulation ICAM1 TNF 8100989 222592 We conclude that rat brain macrophages/microglial cells can be *induced* by gamma-IFN and to express [ICAM-1] . Positive_regulation ICAM1 TNF 8102141 225840 Histamine and cis-urocanic acid augment *mediated* induction of keratinocyte [intercellular adhesion molecule-1] expression . Positive_regulation ICAM1 TNF 8103747 228959 In addition , C3 deposition , the expression of [ICAM-1] , and cell aggregation were *enhanced* by both and interferon-gamma . Positive_regulation ICAM1 TNF 8105755 231412 and IL-1 beta were strong *inducers* of [ICAM-1] expression on 74 % and 82 % of the cells , respectively . Positive_regulation ICAM1 TNF 8110495 241812 The *induced* upregulation of [ICAM-1] occurs on the transcriptional level . Positive_regulation ICAM1 TNF 8214008 231542 Both interferon-gamma and *induced* the [intercellular adhesion molecule-1] ( CD54 ) in the cytoplasm and on the surface of nearly all myotubes . Positive_regulation ICAM1 TNF 8364888 229220 The combined effect of IL-6 and consistently *caused* an increased expression of [ICAM-1] , which was greater than the sum of each one alone and also sustained for 72 h following cytokine withdrawal . Positive_regulation ICAM1 TNF 8390537 220628 Pretreatment of endothelial cells with 10 mM putrescine or 100 microM dansylcadaverine also inhibited *induction* of [ICAM-1] expression and VCAM-1 expression . Positive_regulation ICAM1 TNF 8392091 224734 In previous studies we showed that cultured human keratinocytes expressed the 55-kD TNF receptor (TNFR) and that its expression the important for *mediated* upregulation of [intercellular adhesion molecule-1] ( ICAM-1 ) expression on keratinocytes . Positive_regulation ICAM1 TNF 8392091 224735 Since in previous studies UVB irradiation transiently inhibited *induced* human keratinocyte [ICAM-1] expression , it is proposed that UVB radiation induced biphasic modulation of human keratinocyte 55-kD TNFR expression may affect the capacity of these cells to respond to TNF alpha . Positive_regulation ICAM1 TNF 8392131 224797 Surface protein expression of vascular cell adhesion molecule-1 , endothelial leukocyte adhesion molecule-1 , or [intercellular adhesion molecule-1] , which is *induced* by , interleukin-1 , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation ICAM1 TNF 8575077 350037 Furthermore , inhibition *prevented* the upregulation of lung tissue IL-1 beta , IL-6 , cytokine induced neutrophil chemoattractant , and E-selectin ( ELAM-1 ) but not [intercellular adhesion molecule-1] mRNAs in response to IL-2 . Positive_regulation ICAM1 TNF 8583950 341326 [ICAM-1] was constitutively expressed on unstimulated cells and the expression was *increased* by stimulation ( 20 hr ) . Positive_regulation ICAM1 TNF 8589921 337541 FACS-analysis revealed PGE1 to inhibit induced *upregulation* of [ICAM-1] , but not of VCAM-1 on EC . Positive_regulation ICAM1 TNF 8589921 337542 We conclude that PGE1 supresses T-cell adhesion to EC by selectively inhibiting induced *upregulation* of [ICAM-1] on EC . Positive_regulation ICAM1 TNF 8595959 351156 *Induction* of [intercellular adhesion molecule-1] by through the 55-kDa receptor is dependent on protein kinase C in human retinal pigment epithelial cells . Positive_regulation ICAM1 TNF 8595959 351157 To determine second messenger signaling pathways associated with *mediated* induction of [intercellular adhesion molecule (ICAM)-1] expression on human retinal pigment epithelial ( HRPE ) cells , a cell type known to express only the 55-kDa TNF receptor ( TNFR p55 ) . Positive_regulation ICAM1 TNF 8596155 342151 *induced* [ICAM-1] expression was not decreased by PUVA , however , and pretreatment only partially decreased ICAM-1 expression . Positive_regulation ICAM1 TNF 8606504 352586 Labeling had no effect on EC proliferation rates nor on *induced* upregulation of [ICAM] expression . Positive_regulation ICAM1 TNF 8608731 342798 produced *increases* in beta 1-integrin and [ICAM-1] expression which were also density independent . Positive_regulation ICAM1 TNF 8619443 353994 The *upregulation* of CD36 and [intercellular adhesion molecule-1] by soluble recombinant ( sr ) <-tumor necrosis factor-alpha> or sr-interferon-gamma did not modify the IRBC interactions with SBECs at the ultrastructural level . Positive_regulation ICAM1 TNF 8632057 357225 Basal expression of [ICAM-1] molecules was *enhanced* by and to a lesser extent by IFN-beta , but was not affected by IFN-gamma . Positive_regulation ICAM1 TNF 8663191 368409 All three agonists induce de novo expression of E-selectin ( CD62E ) and vascular cell adhesion molecule-1 ( CD106 ) and increase expression of intercellular adhesion molecule-1 ( CD54 ) at 4 h . *induces* sustained increases in vascular cell adhesion molecule-1 and [intercellular adhesion molecule-1] and increases human leukocyte antigen class I molecules at 24 h . Positive_regulation ICAM1 TNF 8702532 375477 reduced the amount of syndecan-1 protein in EA.hy 926 cells in both the presence and absence of serum and , at the same time , *induced* the expression of [intercellular adhesion molecule-1] ( ICAM-1 ) . Positive_regulation ICAM1 TNF 8713799 376650 In this cell line *induced* the simultaneous appearance of stress fibers and of [ICAM-1] , which was clustered predominantly on endothelial cell projections . Positive_regulation ICAM1 TNF 8780174 380055 The same agents had no significant effect on the constitutive and *stimulated* expression of [intercellular adhesion molecule 1] ( ICAM-1 ) , whereas the effect on vascular cell adhesion molecule 1 ( VCAM-1 ) expression was variable depending on cell culture conditions . Positive_regulation ICAM1 TNF 8785389 371453 Stimulation with IL-1 beta or *resulted* in time- and dose dependent upregulation of [ICAM-1] mRNA transcript and increased cell-surface immunoreactive protein expression . Positive_regulation ICAM1 TNF 8806799 382669 Histamine enhanced the *induced* expression of E-selectin and [ICAM-1] on vascular endothelial cells . Positive_regulation ICAM1 TNF 8806799 382671 *induces* the expression of E-selectin and [intercellular adhesion molecule-1] ( ICAM-1 ) on human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation ICAM1 TNF 8806799 382737 In this report , we show that histamine concentration-dependently enhances the *induced* expression of E-selectin and [ICAM-1] on HUVEC . Positive_regulation ICAM1 TNF 8842442 387275 Herbimycin A inhibited both VCAM-1 and [ICAM-1] expression *induced* by . Positive_regulation ICAM1 TNF 8842442 387277 In contrast , vanadate differentially affected *induced* expression of these molecules with maximal E-selectin and [ICAM-1] expression being slightly enhanced and VCAM-1 expression dose-dependently reduced . Positive_regulation ICAM1 TNF 8843727 387424 ( TNF-alpha ; 10 ng/ml ) *increased* endothelial [ICAM-1] , E-selectin , and VCAM-1 ; Positive_regulation ICAM1 TNF 8869681 389334 By contrast , the expression of the [intercellular adhesion molecule-1] ( ICAM-1 ) , tested as control , on five melanoma cell lines , was greatly *enhanced* by IFN-gamma and . Positive_regulation ICAM1 TNF 8870693 389443 *enhanced* [ICAM-1] expression by synovial cells and endothelial cells , whereas VCAM-1 or E-selectin expression was not enhanced on either cell type . Positive_regulation ICAM1 TNF 8879188 390699 These results showed that and IFN gamma *induce* [ICAM-1] expression and infiltration of neutrophils in the lung . Positive_regulation ICAM1 TNF 8880099 390763 [ICAM-1] expression was *induced* by in 1 of the 5 SCLC lines ( National Cancer Institute ( NCI ) H211 ) , and upregulated in 2 of the 5 NSCLC lines ( NCI H460 and NCI H838 ) . Positive_regulation ICAM1 TNF 8902648 393873 UVB radiation suppresses the *induced* expression of E-selectin and [ICAM-1] on cultured human umbilical vein endothelial cells . Positive_regulation ICAM1 TNF 8904994 394045 Stimulation with ( TNF-alpha ) and interferon-gamma (IFN-gamma) *resulted* , in addition to interleukin-(IL-)4 , in selective upregulation of [ICAM-1] expression . Positive_regulation ICAM1 TNF 8906207 394114 When supernatants of alveolar macrophages , recovered from patients exhibiting a late asthmatic response after allergen exposure , were tested on HUVEC cultures , a *dependent* [ICAM-1] and E-selectin overexpression was observed . Positive_regulation ICAM1 TNF 8906209 394121 *induced* [ICAM-1] surface expression in airway epithelial cells in vitro : possible signal transduction mechanisms . Positive_regulation ICAM1 TNF 8906209 394123 ( 0.015-150 ng/mL ) significantly *enhanced* [ICAM-1] surface expression ( measured by flow cytometry ) in a dose and time dependent manner , with peak expression seen at 24 hours . Positive_regulation ICAM1 TNF 8906209 394124 *induced* [ICAM-1] expression also was inhibited by pre- and coincubation of TNF alpha with 3 micrograms/mL soluble TNF-R1 or by the PKC inhibitor , Calphostin C ( 0.1 and 0.5 microM ) . Positive_regulation ICAM1 TNF 8906209 394125 The ROI scavengers , dimethylthiourea ( 4 mM ) , and dimethyl sulfoxide ( 0.001 % ) , enhanced *induced* [ICAM-1] expression . Positive_regulation ICAM1 TNF 8921427 396807 Similarly , cell surface expression of [ICAM-1] was *induced* by the IL-1 or treatment . Positive_regulation ICAM1 TNF 8930885 397460 Apigenin inhibits *induced* [intercellular adhesion molecule-1] upregulation in vivo . Positive_regulation ICAM1 TNF 8937718 398384 In this study we have investigated the effects of the tyrosine kinase inhibitors , ST638 , tyrphostin AG 1288 and genistein , on *induced* [ICAM-1] expression in human alveolar epithelial ( A549 ) and vascular endothelial ( EAhy926 ) cell lines and also normal human lung microvascular endothelial cells ( HLMVEC ) . Positive_regulation ICAM1 TNF 8937718 398385 ST638 ( 100 microM ) significantly ( P < 0.01 ) inhibited ICAM-1 expression on HLMVEC endothelial cells induced by 0.01 ng ml-1 TNF alpha at 4 or 24 h or 0.1 ng ml-1 at 4 h , but increased [ICAM-1] expression *induced* by 0.1 ng ml-1 at 24 h. ST638 did not significantly change the expression of PMA stimulated ICAM-1 on either A549 epithelial , EAhy926 or HLMVEC endothelial cells . Positive_regulation ICAM1 TNF 8937718 398386 4. These results show that tyrosine kinase inhibitors alter *induced* [ICAM-1] expression , but that the cell type , concentration of TNF alpha and time of exposure to this cytokine determine whether expression is decreased or increased by the inhibitor . Positive_regulation ICAM1 TNF 8937718 398387 An increased understanding of the signal transduction pathway ( s ) involved in *induced* [ICAM-1] expression on lung epithelial and vascular endothelial cells may be of potential therapeutic value in the treatment of inflammatory disease . Positive_regulation ICAM1 TNF 8982701 403883 Butein prevented the up-regulation of [ICAM-1] expression *mediated* by or PMA on human umbilical vein endothelial cells in a dose dependent manner . Positive_regulation ICAM1 TNF 9006341 410722 In conclusion , apparently is *required* for PbA induced endothelial [ICAM-1] up-regulation and subsequent microvascular pathology resulting in fatal CM . Positive_regulation ICAM1 TNF 9008098 405036 Cell surface enzyme immunoassay showed that INFnu , IL-1beta , or *stimulated* expression of [ICAM-1] , or VCAM-1 on MC after 24 hours . Positive_regulation ICAM1 TNF 9012737 411080 This fatty acid induced inhibitory activity was reflected in the ability of the mediators to decrease the *induced* expression of the following endothelial adhesion molecules : [intercellular adhesion molecule-1] ( ICAM-1 ) , E-selectin , and vascular cell adhesion molecule-1 ( VCAM-1 ) , measured by both enzyme linked immunosorbent assay and flow cytometric analysis . Positive_regulation ICAM1 TNF 9015189 411921 Stimulation of IEC-4.1 cells with LPS or markedly *increased* the surface expression of both [ICAM-1] and VCAM-1 , which correlated with the increased binding of macrophages to the stimulated IEC-4.1 cells . Positive_regulation ICAM1 TNF 9022083 413241 To determine modes of retinoid action in the modulation of inflammatory responses , we explored effects of all-trans-retinoic acid ( t-RA ) on the *induced* expression of vascular cell adhesion molecule-1 ( VCAM-1 ) , [intercellular adhesion molecule-1] ( ICAM-1 ) , and E-selectin in cultured human dermal microvascular endothelial cells . Positive_regulation ICAM1 TNF 9022083 413246 Pretreatment with t-RA specifically prevented *induced* VCAM-1 expression , but not [ICAM-1] and E-selectin induction . Positive_regulation ICAM1 TNF 9029122 413584 The *induced* increases in both [ICAM-1] and VCAM-1 were dose dependent , with significant up-regulation noted at 5 microg/kg and maximal increases occurring at 10 to 25 microg/kg . Positive_regulation ICAM1 TNF 9030094 413758 Failure to block biosynthesis of E-selectin and [ICAM-1] *induced* by and IL-1 beta indicates the inhibitory effect exerted by serotonin was selective in nature . Positive_regulation ICAM1 TNF 9039974 415838 This evidence contrasts with previously reported findings indicating that , in human cultured keratinocytes , [ICAM-1] expression is *induced* by IFN-gamma and , and not by either IL-1 or LPS . Positive_regulation ICAM1 TNF 9052593 417171 We found that 17 beta-estradiol augmented the *induced* expression of endothelial leukocyte adhesion molecule-1 , [intercellular adhesion molecule-1] , and vascular cell adhesion molecule-1 by 107 , 9 , and 39 % , respectively . Positive_regulation ICAM1 TNF 9082943 420924 These data suggest that class II MHC antigens and [ICAM-1] on fibroblasts and endothelial cells are *induced* by IFN gamma and in an early stage of SSc after the influx of mononuclear-cells , and may be important in the putative autoimmune response and in the perpetuation of fibrotic processes in SSc . Positive_regulation ICAM1 TNF 9105426 423487 Role of tyrosine kinase enzymes in and IL-1 *induced* expression of [ICAM-1] and VCAM-1 on human umbilical vein endothelial cells . Positive_regulation ICAM1 TNF 9106260 424458 Since adhesion molecules ( AM ) induced on endothelial cells ( EC ) play an important role in T-cell migration into the CNS , the objective of this study was to examine the effect of IFN beta-1b on the expression of the AM , [ICAM-1] , V-CAM and E-selection *induced* on EC by IFN-gamma , , or IL-1 beta . Positive_regulation ICAM1 TNF 9129203 426801 In contrast , the sensitivity toward TNFR2 mediated effects , such as [ICAM-1] *induction* by membrane bound , is increased on brain and lung MVEC expressing increased levels of TNFR2 . Positive_regulation ICAM1 TNF 9143267 428633 Soluble p55 ( sp55 ) receptors , but not soluble p75 ( sp75 ) receptors , were found to reduce the *induced* VCAM-1 and [ICAM-1] expression in both the glioma cell line and the primary cell culture . Positive_regulation ICAM1 TNF 9155652 431620 The specific *role* of in mediating [ICAM-1] expression in cultured monocytes could be confirmed by the finding that a neutralizing anti-TNF-alpha antibody partially down-regulated ICAM-1 expression . Positive_regulation ICAM1 TNF 9178691 434233 When added with 100 U/mL IFN-gamma , *enhanced* MHC class II and [ICAM-1] expression on ISMCs and T-cell proliferation . Positive_regulation ICAM1 TNF 9184788 436673 Subthreshold hyperoxia potentiates *induced* [ICAM-1] expression on cultured pulmonary microvascular endothelial cells . Positive_regulation ICAM1 TNF 9185715 436745 Decreased expression of [ICAM-1] and its *induction* by on breast-cancer cells in vitro . Positive_regulation ICAM1 TNF 9188493 437220 *Induction* of [ICAM-1] gene transcription by has previously been shown to be dependent upon a region of the ICAM-1 5'-flanking sequences that contains a modified kappaB site . Positive_regulation ICAM1 TNF 9188493 437221 These results demonstrate the requirement for specific flanking sequences surrounding a kappaB binding site for functional transcription factor binding and transactivation and *mediated* induction of [ICAM-1] . Positive_regulation ICAM1 TNF 9197378 438548 In addition , pretreatment of infected monocytes with a TNF-alpha synthesis inhibitor , RP 55778 , or with MAbs directed against IL-1beta , confirmed the *role* of and IL-1beta in the regulation of CD18 , CD44 , and [CD54] expression . Positive_regulation ICAM1 TNF 9209275 441017 TBP I completely abolished TNF induced IL-6 production and E-selectin induction , while it partially inhibited induced IL-8 production and *up-regulation* of [ICAM-1] and VCAM-1 . Positive_regulation ICAM1 TNF 9216201 407113 N-acetylcysteine , an antioxidant , decreased the *induced* expression of [intercellular adhesion molecule-1] on cultured epithelial cells from human bronchi ( BEAS-2A ) , and inhibited IL-8 production by those cells . Positive_regulation ICAM1 TNF 9234165 445254 The IC50 for the *induced* ELAM-1 and [ICAM-1] expressions were 1.5 x 10 ( -5 ) M and 3.1 x 10 ( -5 ) M , respectively . Positive_regulation ICAM1 TNF 9234165 445257 In addition , protein C-kinase ( PKC ) inhibitor H7 also inhibited the ELAM-1 and [ICAM-1] expressions *induced* by IL-1 beta and . Positive_regulation ICAM1 TNF 9247582 446496 *induced* [intercellular adhesion molecule (ICAM)-1] expression in the keratinocytes from normal and TNFR2 ( - ) mice , but not in those from TNFR1 ( - ) mice . Positive_regulation ICAM1 TNF 9247583 446497 Thus , only in MVEC lacking TNFR2 , neither membrane bound nor soluble *cause* the up-regulation of [ICAM-1] in vitro . Positive_regulation ICAM1 TNF 9255503 447713 In addition , both IFN-gamma and *increased* [ICAM-1] expression on the cultured HCE cells dramatically . Positive_regulation ICAM1 TNF 9266024 449365 IL-1 beta and synergistically *increased* the expression of [ICAM-1] , but they failed to induce MHC molecules . Positive_regulation ICAM1 TNF 9329027 457443 Both IFN-gamma and *increased* [ICAM-1] expression of RG2 cells in vitro . Positive_regulation ICAM1 TNF 9329027 457445 Expression of [ICAM-1] was not *enhanced* by combined with RMP-7 . Positive_regulation ICAM1 TNF 9366433 463254 A dual radiolabeled mAb technique was used to quantify constitutive and *induced* expression of [ICAM-1] , VCAM-1 , E-selectin , and P-selectin in different vascular beds ( lung , heart , stomach , mesentery , small intestine , large intestine , and muscle ) in wild-type and SCID mice . Positive_regulation ICAM1 TNF 9371591 464209 significantly *enhanced* WNV induced increases in E-selectin , P-selectin , [ICAM-1] , and VCAM-1 expression , while IFN-gamma enhanced WNV induced ICAM-1 expression . Positive_regulation ICAM1 TNF 9378369 465559 Because and interleukin-1 (IL-1) are potent *inducers* of [ICAM-1] , we investigated whether TNF-alpha and IL-1 beta mRNA increase prior to the increase in ICAM-1 mRNA in hyperoxia exposed mouse lungs . Positive_regulation ICAM1 TNF 9384699 408092 *Induction* of death ( CD95/FAS ) , activation and adhesion ( [CD54] ) molecules on blast cells of acute myelogenous leukemias by and IFN-gamma . Positive_regulation ICAM1 TNF 9390134 467505 The up-regulation of [ICAM-1] , in turn , may be *due* to high circulating levels of interferon-gamma and/or . Positive_regulation ICAM1 TNF 9401798 469513 These findings suggest that in IPM and HIV-PM , enhanced [ICAM-1] and LFA-1 expression possibly *induced* by , may regulate the homing process of selected lymphocyte clones in muscle tissue . Positive_regulation ICAM1 TNF 9407069 470798 Northern blot analysis revealed that *induced* both [ICAM-1] and IL-8 expression in either the A549 lung epithelial cell line or the human microvessel endothelial cell line ( HMEC-1 ) . Positive_regulation ICAM1 TNF 9409229 471403 In cultured human smooth muscle cells from coronary arteries and saphenous veins , and interleukin-1 beta (IL-1 beta) *induced* the expression of intercellular adhesion molecule ( [ICAM-1] ) and vascular cell adhesion molecule ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation ICAM1 TNF 9409229 471441 The stability of *induced* [ICAM-1] and VCAM-1 expression at mRNA and protein level was not altered by cicaprost . Positive_regulation ICAM1 TNF 9409637 471485 further *enhanced* the HRV induced increase in [ICAM-1] expression on epithelial cells , peaking at day 4 after infection , whilst IL-8 exhibited a steady increase in ICAM-1 expression over 14 days . Positive_regulation ICAM1 TNF 9414135 471836 As TNF is a potent inducer of ICAM-1 expression , it is concluded that in these experiments the inhibition of production by PTX concomitantly *resulted* in the inhibition of the upregulation of [ICAM-1] . Positive_regulation ICAM1 TNF 9421277 472478 MPA-pretreatment of EC did not affect *induced* surface expression of [ICAM-1] . Positive_regulation ICAM1 TNF 9430492 482110 Although IL-1 did not support GM-CSF induced eosinophil transendothelial migration , IL-1 and *induced* equivalent expression of [ICAM-1] on HUVEC . Positive_regulation ICAM1 TNF 9442377 475215 We argue that in vivo RelA homodimers are likely to play a dominant role in *induced* [ICAM-1] transcription in monocytic cells . Positive_regulation ICAM1 TNF 9448041 483779 and IL-1beta *increased* the expression of [ICAM-1] , E-selectin , and VCAM-1 , whereas IL-4 induced only that of VCAM-1 . Positive_regulation ICAM1 TNF 9486659 488352 We have generated populations of endothelial cells expressing wild-type and a proteolysis-resistant mutation of IkappaB that is lacking the 36 N-terminal amino acids ( IkappaBdeltaN ) in order to examine the effects of expression of the mutated IkappaB on *induced* E-selectin and [ICAM-1] expression . Positive_regulation ICAM1 TNF 9486918 488470 In addition , *induced* [CD54] expression in one further case . Positive_regulation ICAM1 TNF 9500713 490955 On HLVEC , PGE1 down-regulated *induced* expression of endothelial cell leukocyte adhesion molecule 1 and vascular adhesion molecule 1 , but not [intercellular adhesion molecule 1] . Positive_regulation ICAM1 TNF 9521860 493851 and 9-cis-retinoic acid synergistically *induce* [ICAM-1] expression : evidence for interaction of retinoid receptors with NF-kappa B . Positive_regulation ICAM1 TNF 9521860 493852 and 9-cis-retinoic acid ( 9-cis-R ) synergistically *enhance* [ICAM-1] protein expression in immortalized human aortic endothelial cells ( HAECTs ) . Positive_regulation ICAM1 TNF 9538628 497752 and IL-1 released from mononuclear cells *induced* the up-regulation of [ICAM-1] expression and this may be related to the immune pathogenesis of IgA nephropathy . Positive_regulation ICAM1 TNF 9560314 500463 We re-evaluated the reported role of reactive oxygen metabolites ( ROMs ) in signalling *upregulation* of intercellular adhesion molecule 1 ( [ICAM-1] ) on endothelial cells by in vitro . Positive_regulation ICAM1 TNF 9570915 501659 After two immunomagnetic purification steps , a homogenous population of HDMEC was obtained which showed typical cobblestone morphology , expressed CD31 and von Willebrand factor , proliferated in response to vascular endothelial growth factor , upregulated the expression of [intercellular adhesion molecule-1] and vascular adhesion molecule-1 in *response* to , and formed capillary-like tubes in a three-dimensional collagen type I matrix . Positive_regulation ICAM1 TNF 9607608 508570 We have used the glutathione peroxidase (GPx) mimic BXT-51072 to assess the possibility that endogenous hydroperoxides play a role in the *induced* expression of [ICAM-1] and VCAM-1 by monolayers of human endothelial cells . Positive_regulation ICAM1 TNF 9607608 508572 The GPx mimic BXT-51072 strongly inhibits the *induced* and cycloheximide-sensitive expression of [ICAM-1] and VCAM-1 . Positive_regulation ICAM1 TNF 9610617 508787 and LPS also *induced* MCP-1 and [ICAM-1] gene expression . Positive_regulation ICAM1 TNF 9620666 510566 The NO donors , but not 8-bromo-cGMP , decreased *induced* VCAM-1 , [ICAM-1] , and E-selectin expression by 11-70 % . Positive_regulation ICAM1 TNF 9632914 513116 In addition , IFN gamma appeared to completely override the [ICAM-1] upregulation *induced* by IL-1 beta , IL-8 and , during HRV infection . Positive_regulation ICAM1 TNF 9674607 520222 Inhibition of *attenuates* infarct volume and [ICAM-1] expression in ischemic mouse brain . Positive_regulation ICAM1 TNF 9688319 521939 We have studied the effect of interferon (IF) beta-1a on the basal and *induced* [intercellular adhesion molecule 1] ( ICAM 1 ) expression and fluid phase endocytosis ( FPE ) of horseradish peroxidase in cultured rat brain microvascular endothelial cells . Positive_regulation ICAM1 TNF 9688319 521941 Treatment of cultures with IFbeta-1a for 48 h followed by 24-h coincubation with TNFalpha ( 100 U/ml ) and IFbeta-1a ( 1000 U/ml ) resulted in significant downregulation of *induced* [ICAM 1] expression and FPE . Positive_regulation ICAM1 TNF 9688319 521942 Downregulation of *induced* [ICAM 1] expression was not observed when combined treatment with TNFalpha ( 100 U/ml ) and IFbeta-1a ( 1000 U/ml ) for 24 h was followed by 48 h exposure to IFbeta-1a . Positive_regulation ICAM1 TNF 9691914 523159 *induction* of [ICAM-1] expression is mediated by the transcription factor NF-kappa B and can be inhibited by blocking I kappa B alpha degradation . Positive_regulation ICAM1 TNF 9699892 525171 Finally , apo E-DMPC vesicles were also unable to suppress *induced* upregulation of E-selectin or [intercellular adhesion molecule-1] ( ICAM-1 ) . Positive_regulation ICAM1 TNF 9705247 525874 Mobility shift assays and Northern blot analyses further show that the supernatant from TPV infected cells inhibited *induced* activation of the nuclear transcription factor-kappa B ( NF-kappa B ) and transcriptional activation of the E-selectin , VCAM-1 and [ICAM-1] genes . Positive_regulation ICAM1 TNF 9718198 528189 also *increased* the mRNA levels of interleukin-6 (IL-6) and [intercellular adhesion molecule-1] ( ICAM-1 ) . Positive_regulation ICAM1 TNF 9718198 528191 An antioxidant , N-acetyl-L-cysteine , significantly attenuated the TNF-alpha dependent increase in these mRNAs , and simultaneously reduced the activation of NF-kappaB by TNF-alpha , indicating that NF-kappaB mediates the *dependent* expression of IL-6 and [ICAM-1] in ROS17/2.8 cells . Positive_regulation ICAM1 TNF 9732234 530579 Our results show that 1,000 U/ml IFN-gamma *induced* a substantial increase in the expression of both [ICAM-1] molecules and HLA-DR on the cell surface , while the effect of on the expression of these molecules was substantially less prominent . Positive_regulation ICAM1 TNF 9751850 533695 HNMEC differed from human umbilical vein endothelila cells in that ( 1 ) maximal upregulation of [ICAM-1] expression *induced* by IL-1beta or required more time ( 2 ) TNF-alpha was more potent than IL-1beta in VCAM-1 expression , and ( 3 ) dexamethasone inhibited the upregulation of E-selectin expression alone . Positive_regulation ICAM1 TNF 9759860 536551 Selective inhibitors of cytosolic or secretory phospholipase A2 block *induced* activation of transcription factor nuclear factor-kappa B and expression of [ICAM-1] . Positive_regulation ICAM1 TNF 9759860 536567 Moreover , both methyl arachidonyl fluorophosphate and 12-epi-scalaradial blocked *mediated* enhancement of expression of [ICAM-1] . Positive_regulation ICAM1 TNF 9763522 537116 Additional studies have revealed that LacCer mediates the *induced* nuclear factor-kappaB expression and [intercellular adhesion molecule] ( ICAM-1 ) expression in vascular endothelial cells via the redox dependent transcriptional pathway . Positive_regulation ICAM1 TNF 9791729 542512 A neutralizing anti-TNF monoclonal antibody ( cA2 ) was used to study the down regulation of *induced* E-selectin , vascular cell adhesion molecule-1 ( VCAM-1 ) and [intercellular adhesion molecule-1] ( ICAM-1 ) on cultured human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation ICAM1 TNF 9794436 543011 Interestingly , the IL-6/sIL-6R complex inhibited TNF-alpha induced VCAM-1 gene expression but did not affect *induced* [ICAM-1] expression . Positive_regulation ICAM1 TNF 9820785 547938 IFN-gammaand *induced* both dose- and time dependent increases in [ICAM-1] expression . Positive_regulation ICAM1 TNF 9820785 547940 ( 100 U ml-1 ) *induced* a consistent approximately 6.0-fold increase in [ICAM-1] expression . Positive_regulation ICAM1 TNF 9825772 549214 The expression of [ICAM-1] on SK-N-MC was *up-regulated* by or IFN gamma , while IL-1alpha also upregulated ICAM-1 on SK-N-SH cells . Positive_regulation ICAM1 TNF 9830008 551253 We previously demonstrated that and H2O2 differentially *regulate* interleukin-8 (IL-8) and [intercellular adhesion molecule] ( ICAM-1 ) gene expression in endothelial and epithelial cells . Positive_regulation ICAM1 TNF 9830008 551267 Unlike H2O2 , the proinflammatory cytokine *induced* IL-8 and [ICAM-1] in both cell types . Positive_regulation ICAM1 TNF 9832331 551716 *induced* [ICAM-1] and VCAM-1 levels in all EC were similar and significantly higher than in HVCSM ( 2.5- and 5-fold , respectively ) . Positive_regulation ICAM1 TNF 9846848 553944 Resveratrol also significantly inhibited the adhesion of neutrophils to *stimulated* NIH/3T3 [ICAM-1] transfected cells , whereas neutrophils activated by formyl-methionyl-leucyl-phenylalanine did not significantly modify adhesion to NIH/3T3 ICAM-1 transfected cells . Positive_regulation ICAM1 TNF 9852101 554590 Lactosylceramide mediates *induced* [intercellular adhesion molecule-1] ( ICAM-1 ) expression and the adhesion of neutrophil in human umbilical vein endothelial cells . Positive_regulation ICAM1 TNF 9852101 554591 Since lactosylceramide ( LacCer ) accumulates in large quantities in human atherosclerotic plaque , we have explored its role in *induced* expression of [intercellular adhesion molecule-1] ( ICAM-1 ) in human umbilical vein endothelial cells and their consequent adhesion to polymorphonuclear leukocytes ( PMNs ) . Positive_regulation ICAM1 TNF 9852101 554592 The *induced* expression of [ICAM-1] was abrogated by D-1-phenyl-2-decanoylamino-3-morpholino-1-propanol ( D-PDMP ) , an inhibitor of UDP-galactose : glucosylceramide beta ( 1 -- > 4 ) -galactosyltransferase . Positive_regulation ICAM1 TNF 9852101 554593 However , the addition of LacCer reversed the D-PDMP effect on *induced* [ICAM-1] expression in human umbilical vein endothelial cells . Positive_regulation ICAM1 TNF 9854504 555014 *induced* CD11b/CD18 expression on leukocytes and interferon-gamma (IFN-gamma) induced [ICAM-1] expression on tumor cells may play an important role in leukocyte mediated tumor destruction . Positive_regulation ICAM1 TNF 9882562 584188 Expression of membrane bound ( mb ) and soluble ( s ) forms of vascular cell adhesion molecule-1 ( VCAM-1 ) and [intercellular adhesion molecule-1] ( ICAM-1 ) *induced* by has been measured by enzyme linked immunosorbent assay in cultured human brain microvessel endothelial cells . Positive_regulation ICAM1 TNF 9886425 584728 On the other hand , IL-17 alone did not affect ICAM-1 or enhance *induced* [ICAM-1] . Positive_regulation ICAM1 TNF 9887050 584959 stimulated expression of both intercellular adhesion molecule-1 and E-selectin in HUVECs , but in HUAECs , only [intercellular adhesion molecule-1] was *increased* . Positive_regulation ICAM1 TNF 9888295 585082 and IL-1beta *enhanced* [ICAM-1] expression at both the mRNA and protein levels , while IFN-gamma had a modest enhancing effect . Positive_regulation ICAM1 TNF 9893126 586773 ( 100 U/ml ) enhanced binding by 335 % and *up-regulated* intercellular adhesion molecule-1 ( [ICAM-1] ) and vascular cell adhesion molecule-1 ( VCAM-1 ) expression by 505 % and 179 % , respectively , as compared with MM-LDL ( 120 % and 116 % ) and LDL , which had no effect . Positive_regulation ICAM1 TNF 9919421 559221 *stimulated* the expression of [ICAM-1] in a time- and dose dependent manner . Positive_regulation ICAM1 TNF 9919421 559222 These results suggest that the cytokine *regulates* the expression of [ICAM-1] in both human coronary endothelial cells and SMC , and could therefore play an important role in the pathophysiology of inflammatory and immune processes in restenosis after angioplasty . Positive_regulation ICAM1 TNF 9973425 596127 We conclude that the early up-regulation of endothelial [ICAM-1] and VCAM-1 during the elicitation of contact hypersensitivity is primarily *due* to the immune dependent local release of . Positive_regulation ICAM1 TNFSF10 12874246 1115002 In surviving cells , activates NF-kappaB , *induces* expression of E-selectin , [ICAM-1] , and IL-8 , and promotes adhesion of leukocytes . Positive_regulation ICAM2 IL1B 17693924 1882316 Lastly , inhibition of exportin 1 attenuates monocyte chemoattractant protein , IL-8 , and [intercellular adhesion molecule] expression in *response* to stimulation . Positive_regulation ICAM2 IL1B 9409229 471410 In cultured human smooth muscle cells from coronary arteries and saphenous veins , tumor necrosis factor-alpha (TNF-alpha) and *induced* the expression of [intercellular adhesion molecule] ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation ICAM2 IL1B 9529162 496516 We also found that inhibition of tyrosine kinase and p38/RK ( stress activated protein kinase ) pathways prevented *induced* [ICAM] and VCAM protein synthesis , whereas extracellular signal regulated protein kinase ( ERK1/ERK2 ) inhibition did not . Positive_regulation ICAM2 IL1B 9529162 496521 However , hypoxia did enhance *induced* [ICAM] mRNA expression in myocytes . Positive_regulation ICAM2 ITGB2 7744962 306366 The [ICAM-2] peptide also *induces* and CD11c/CD18 mediated binding of THP-1 cells to fibrinogen and iC3b coated on plastic . Positive_regulation ICAM2 PLAU 16728704 1612371 In contrast , exogenous *stimulated* [ICAM] and VCAM adhesion of airway eosinophils . Positive_regulation ICAM2 SELL 10029177 591544 Despite the high level of cellular activation and proliferation induced by PMVEC coculture , the surface expression of adhesion molecules CD11a ( LFA-1 ) , CD11b , CD15s ( sialyl-Lewis x ) , CD43 , and CD44 ( HCAM ) on the total CD34+ population was maintained , and the surface expression of CD49d ( VLA-4 ) , CD54 ( [ICAM] ) , CD58 , and ( L selectin ) *increased* after ex vivo expansion . Positive_regulation ICAM2 TNF 10484438 644095 The dual radiolabeled monoclonal antibody technique was used to quantify constitutive and *induced* expression of intercellular adhesion molecule 1 ( ICAM-1 ) , vascular cell adhesion molecule 1 ( VCAM-1 ) , [ICAM-2] , P-selectin , E-selectin , and platelet-endothelial cell adhesion molecule 1 ( PECAM-1 ) in different vascular beds of normal ( C57Bl/6 ) and RM-1 tumor bearing mice . Positive_regulation ICAM2 TNF 10549609 564997 Treatment with NAC clearly restrained *induced* [ICAM] expression on HUVEC , while preincubation of cells with PDTC showed synergistic effects . Positive_regulation ICAM2 TNF 10580548 570089 *Induction* of [intercellular adhesion molecule] ( ICAM-1 ) , vascular cell adhesion molecule ( VCAM-1 ) and E-selectin by , measured by a radiometric technique , was similar in IVEC and HUVEC , while the induction of E-selectin by IL-1beta on IVEC was limited and significantly different from that observed on HUVEC ( p < 0.001 ) . Positive_regulation ICAM2 TNF 11435740 832695 The *induced* increase in soluble [ICAM] in culture supernatants was unchanged by 1,25-vitamin D ( 3 ) . Positive_regulation ICAM2 TNF 1382639 198291 Exposure of HUVEC to perflubron did not alter the up-regulation of [ICAM] or ELAM in *response* to IL-1 or ( n = 20 ) . Positive_regulation ICAM2 TNF 15574511 1355711 This hypothesis was examined further by *stimulation* of PTC [ICAM] expression by . Positive_regulation ICAM2 TNF 15574511 1355720 Although stimulation of PTC by BMP-7 alone decreased cell surface ICAM expression , it did not affect *induced* [ICAM] expression . Positive_regulation ICAM2 TNF 19148111 2037984 ( 2 ) Digibind could attenuate and reduce *induced* upregulation of endothelial E-selectin , [ICAM] and VCAM expressions . Positive_regulation ICAM2 TNF 22000995 2526257 Oxidative stress significantly contributes to the induced *up-regulation* of [Icam] and iNos in AR42J cells . Positive_regulation ICAM2 TNF 22266330 2575497 To assess in vivo attachment efficiency to endothelial counterligands that vary in their distance from the endothelial cell surface , contrast enhanced ultrasound ( CEU ) molecular imaging of *induced* P-selectin ( long distance ) or [intercellular adhesion molecule-2] ( short distance ) was performed with each agent in murine hind limbs . Positive_regulation ICAM2 TNF 7561050 324170 In contrast , the *induced* expression of plasminogen activator inhibitor-1 and the constitutive expression of [ICAM-2] were unaffected . Positive_regulation ICAM2 TNF 7693806 234206 *increases* the expression of ICAM-1 , but not [ICAM-2] , and induces the expression of ELAM-1 on both EC types . Positive_regulation ICAM2 TNF 8100455 222534 Exposure of HUVEC to perflubron did not alter the upregulation of [ICAM] or ELAM in *response* to IL-1 or ( n = 20 ) . Positive_regulation ICAM2 TNF 8606504 352587 Labeling had no effect on EC proliferation rates nor on *induced* upregulation of [ICAM] expression . Positive_regulation ICAM2 TNF 9409229 471407 In cultured human smooth muscle cells from coronary arteries and saphenous veins , and interleukin-1 beta (IL-1 beta) *induced* the expression of [intercellular adhesion molecule] ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation ICAM2 TNF 9763522 537117 Additional studies have revealed that LacCer mediates the *induced* nuclear factor-kappaB expression and [intercellular adhesion molecule] ( ICAM-1 ) expression in vascular endothelial cells via the redox dependent transcriptional pathway . Positive_regulation ICAM2 TNF 9830008 551254 We previously demonstrated that and H2O2 differentially *regulate* interleukin-8 (IL-8) and [intercellular adhesion molecule] ( ICAM-1 ) gene expression in endothelial and epithelial cells . Positive_regulation ICAM3 IL1B 17693924 1882318 Lastly , inhibition of exportin 1 attenuates monocyte chemoattractant protein , IL-8 , and [intercellular adhesion molecule] expression in *response* to stimulation . Positive_regulation ICAM3 IL1B 9409229 471414 In cultured human smooth muscle cells from coronary arteries and saphenous veins , tumor necrosis factor-alpha (TNF-alpha) and *induced* the expression of [intercellular adhesion molecule] ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation ICAM3 IL1B 9529162 496517 We also found that inhibition of tyrosine kinase and p38/RK ( stress activated protein kinase ) pathways prevented *induced* [ICAM] and VCAM protein synthesis , whereas extracellular signal regulated protein kinase ( ERK1/ERK2 ) inhibition did not . Positive_regulation ICAM3 IL1B 9529162 496522 However , hypoxia did enhance *induced* [ICAM] mRNA expression in myocytes . Positive_regulation ICAM3 ITGAL 23879717 2825485 Moreover , the activated T cells could upregulate [ICAM-3] expression on Nalm-6 cells , and inhibition of interaction *impaired* cytotoxicity of T cells . Positive_regulation ICAM3 PLAU 16728704 1612372 In contrast , exogenous *stimulated* [ICAM] and VCAM adhesion of airway eosinophils . Positive_regulation ICAM3 SELL 10029177 591545 Despite the high level of cellular activation and proliferation induced by PMVEC coculture , the surface expression of adhesion molecules CD11a ( LFA-1 ) , CD11b , CD15s ( sialyl-Lewis x ) , CD43 , and CD44 ( HCAM ) on the total CD34+ population was maintained , and the surface expression of CD49d ( VLA-4 ) , CD54 ( [ICAM] ) , CD58 , and ( L selectin ) *increased* after ex vivo expansion . Positive_regulation ICAM3 TNF 10549609 564998 Treatment with NAC clearly restrained *induced* [ICAM] expression on HUVEC , while preincubation of cells with PDTC showed synergistic effects . Positive_regulation ICAM3 TNF 10580548 570090 *Induction* of [intercellular adhesion molecule] ( ICAM-1 ) , vascular cell adhesion molecule ( VCAM-1 ) and E-selectin by , measured by a radiometric technique , was similar in IVEC and HUVEC , while the induction of E-selectin by IL-1beta on IVEC was limited and significantly different from that observed on HUVEC ( p < 0.001 ) . Positive_regulation ICAM3 TNF 11435740 832696 The *induced* increase in soluble [ICAM] in culture supernatants was unchanged by 1,25-vitamin D ( 3 ) . Positive_regulation ICAM3 TNF 1382639 198293 Exposure of HUVEC to perflubron did not alter the up-regulation of [ICAM] or ELAM in *response* to IL-1 or ( n = 20 ) . Positive_regulation ICAM3 TNF 15574511 1355712 This hypothesis was examined further by *stimulation* of PTC [ICAM] expression by . Positive_regulation ICAM3 TNF 15574511 1355721 Although stimulation of PTC by BMP-7 alone decreased cell surface ICAM expression , it did not affect *induced* [ICAM] expression . Positive_regulation ICAM3 TNF 19148111 2037985 ( 2 ) Digibind could attenuate and reduce induced *upregulation* of endothelial E-selectin , [ICAM] and VCAM expressions . Positive_regulation ICAM3 TNF 22000995 2526258 Oxidative stress significantly contributes to the *induced* up-regulation of [Icam] and iNos in AR42J cells . Positive_regulation ICAM3 TNF 8100455 222536 Exposure of HUVEC to perflubron did not alter the upregulation of [ICAM] or ELAM in *response* to IL-1 or ( n = 20 ) . Positive_regulation ICAM3 TNF 8606504 352588 Labeling had no effect on EC proliferation rates nor on *induced* upregulation of [ICAM] expression . Positive_regulation ICAM3 TNF 9409229 471411 In cultured human smooth muscle cells from coronary arteries and saphenous veins , and interleukin-1 beta (IL-1 beta) *induced* the expression of [intercellular adhesion molecule] ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation ICAM3 TNF 9763522 537118 Additional studies have revealed that LacCer mediates the *induced* nuclear factor-kappaB expression and [intercellular adhesion molecule] ( ICAM-1 ) expression in vascular endothelial cells via the redox dependent transcriptional pathway . Positive_regulation ICAM3 TNF 9830008 551255 We previously demonstrated that and H2O2 differentially *regulate* interleukin-8 (IL-8) and [intercellular adhesion molecule] ( ICAM-1 ) gene expression in endothelial and epithelial cells . Positive_regulation ICAM4 EPHB2 22147898 2548635 These results demonstrate that activation *induces* phosphorylation of cytoskeletal proteins and the adhesion molecule [ICAM-4] , promoting SS RBC adhesion to the endothelium . Positive_regulation ICAM4 IL1B 17693924 1882320 Lastly , inhibition of exportin 1 attenuates monocyte chemoattractant protein , IL-8 , and [intercellular adhesion molecule] expression in *response* to stimulation . Positive_regulation ICAM4 IL1B 9409229 471418 In cultured human smooth muscle cells from coronary arteries and saphenous veins , tumor necrosis factor-alpha (TNF-alpha) and *induced* the expression of [intercellular adhesion molecule] ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation ICAM4 IL1B 9529162 496518 We also found that inhibition of tyrosine kinase and p38/RK ( stress activated protein kinase ) pathways prevented *induced* [ICAM] and VCAM protein synthesis , whereas extracellular signal regulated protein kinase ( ERK1/ERK2 ) inhibition did not . Positive_regulation ICAM4 IL1B 9529162 496523 However , hypoxia did enhance *induced* [ICAM] mRNA expression in myocytes . Positive_regulation ICAM4 PLAU 16728704 1612373 In contrast , exogenous *stimulated* [ICAM] and VCAM adhesion of airway eosinophils . Positive_regulation ICAM4 SELL 10029177 591546 Despite the high level of cellular activation and proliferation induced by PMVEC coculture , the surface expression of adhesion molecules CD11a ( LFA-1 ) , CD11b , CD15s ( sialyl-Lewis x ) , CD43 , and CD44 ( HCAM ) on the total CD34+ population was maintained , and the surface expression of CD49d ( VLA-4 ) , CD54 ( [ICAM] ) , CD58 , and ( L selectin ) *increased* after ex vivo expansion . Positive_regulation ICAM4 TNF 10549609 564999 Treatment with NAC clearly restrained *induced* [ICAM] expression on HUVEC , while preincubation of cells with PDTC showed synergistic effects . Positive_regulation ICAM4 TNF 10580548 570091 *Induction* of [intercellular adhesion molecule] ( ICAM-1 ) , vascular cell adhesion molecule ( VCAM-1 ) and E-selectin by , measured by a radiometric technique , was similar in IVEC and HUVEC , while the induction of E-selectin by IL-1beta on IVEC was limited and significantly different from that observed on HUVEC ( p < 0.001 ) . Positive_regulation ICAM4 TNF 11435740 832697 The *induced* increase in soluble [ICAM] in culture supernatants was unchanged by 1,25-vitamin D ( 3 ) . Positive_regulation ICAM4 TNF 1382639 198295 Exposure of HUVEC to perflubron did not alter the up-regulation of [ICAM] or ELAM in *response* to IL-1 or ( n = 20 ) . Positive_regulation ICAM4 TNF 15574511 1355713 This hypothesis was examined further by *stimulation* of PTC [ICAM] expression by . Positive_regulation ICAM4 TNF 15574511 1355722 Although stimulation of PTC by BMP-7 alone decreased cell surface ICAM expression , it did not affect *induced* [ICAM] expression . Positive_regulation ICAM4 TNF 19148111 2037986 ( 2 ) Digibind could attenuate and reduce *induced* upregulation of endothelial E-selectin , [ICAM] and VCAM expressions . Positive_regulation ICAM4 TNF 22000995 2526259 Oxidative stress significantly contributes to the induced *up-regulation* of [Icam] and iNos in AR42J cells . Positive_regulation ICAM4 TNF 8100455 222538 Exposure of HUVEC to perflubron did not alter the upregulation of [ICAM] or ELAM in *response* to IL-1 or ( n = 20 ) . Positive_regulation ICAM4 TNF 8606504 352589 Labeling had no effect on EC proliferation rates nor on *induced* upregulation of [ICAM] expression . Positive_regulation ICAM4 TNF 9409229 471415 In cultured human smooth muscle cells from coronary arteries and saphenous veins , and interleukin-1 beta (IL-1 beta) *induced* the expression of [intercellular adhesion molecule] ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation ICAM4 TNF 9763522 537119 Additional studies have revealed that LacCer mediates the *induced* nuclear factor-kappaB expression and [intercellular adhesion molecule] ( ICAM-1 ) expression in vascular endothelial cells via the redox dependent transcriptional pathway . Positive_regulation ICAM4 TNF 9830008 551256 We previously demonstrated that and H2O2 differentially *regulate* interleukin-8 (IL-8) and [intercellular adhesion molecule] ( ICAM-1 ) gene expression in endothelial and epithelial cells . Positive_regulation ICAM5 IL1B 17693924 1882322 Lastly , inhibition of exportin 1 attenuates monocyte chemoattractant protein , IL-8 , and [intercellular adhesion molecule] expression in *response* to stimulation . Positive_regulation ICAM5 IL1B 9409229 471422 In cultured human smooth muscle cells from coronary arteries and saphenous veins , tumor necrosis factor-alpha (TNF-alpha) and *induced* the expression of [intercellular adhesion molecule] ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation ICAM5 IL1B 9529162 496519 We also found that inhibition of tyrosine kinase and p38/RK ( stress activated protein kinase ) pathways prevented *induced* [ICAM] and VCAM protein synthesis , whereas extracellular signal regulated protein kinase ( ERK1/ERK2 ) inhibition did not . Positive_regulation ICAM5 IL1B 9529162 496524 However , hypoxia did enhance *induced* [ICAM] mRNA expression in myocytes . Positive_regulation ICAM5 MMP28 20045450 2211414 Additional studies suggest that *mediated* cleavage of [ICAM-5] occurs at amino acid 780 , so that the major portion of the ectodomain is released . Positive_regulation ICAM5 MMP7 20045450 2211429 Additional studies suggest that *mediated* cleavage of [ICAM-5] occurs at amino acid 780 , so that the major portion of the ectodomain is released . Positive_regulation ICAM5 PLAU 16728704 1612374 In contrast , exogenous *stimulated* [ICAM] and VCAM adhesion of airway eosinophils . Positive_regulation ICAM5 SELL 10029177 591547 Despite the high level of cellular activation and proliferation induced by PMVEC coculture , the surface expression of adhesion molecules CD11a ( LFA-1 ) , CD11b , CD15s ( sialyl-Lewis x ) , CD43 , and CD44 ( HCAM ) on the total CD34+ population was maintained , and the surface expression of CD49d ( VLA-4 ) , CD54 ( [ICAM] ) , CD58 , and ( L selectin ) *increased* after ex vivo expansion . Positive_regulation ICAM5 TNF 10549609 565000 Treatment with NAC clearly restrained *induced* [ICAM] expression on HUVEC , while preincubation of cells with PDTC showed synergistic effects . Positive_regulation ICAM5 TNF 10580548 570092 *Induction* of [intercellular adhesion molecule] ( ICAM-1 ) , vascular cell adhesion molecule ( VCAM-1 ) and E-selectin by , measured by a radiometric technique , was similar in IVEC and HUVEC , while the induction of E-selectin by IL-1beta on IVEC was limited and significantly different from that observed on HUVEC ( p < 0.001 ) . Positive_regulation ICAM5 TNF 11435740 832698 The *induced* increase in soluble [ICAM] in culture supernatants was unchanged by 1,25-vitamin D ( 3 ) . Positive_regulation ICAM5 TNF 1382639 198297 Exposure of HUVEC to perflubron did not alter the up-regulation of [ICAM] or ELAM in *response* to IL-1 or ( n = 20 ) . Positive_regulation ICAM5 TNF 15574511 1355714 This hypothesis was examined further by *stimulation* of PTC [ICAM] expression by . Positive_regulation ICAM5 TNF 15574511 1355723 Although stimulation of PTC by BMP-7 alone decreased cell surface ICAM expression , it did not affect *induced* [ICAM] expression . Positive_regulation ICAM5 TNF 19148111 2037987 ( 2 ) Digibind could attenuate and reduce induced *upregulation* of endothelial E-selectin , [ICAM] and VCAM expressions . Positive_regulation ICAM5 TNF 22000995 2526260 Oxidative stress significantly contributes to the induced *up-regulation* of [Icam] and iNos in AR42J cells . Positive_regulation ICAM5 TNF 8100455 222540 Exposure of HUVEC to perflubron did not alter the upregulation of [ICAM] or ELAM in *response* to IL-1 or ( n = 20 ) . Positive_regulation ICAM5 TNF 8606504 352590 Labeling had no effect on EC proliferation rates nor on *induced* upregulation of [ICAM] expression . Positive_regulation ICAM5 TNF 9409229 471419 In cultured human smooth muscle cells from coronary arteries and saphenous veins , and interleukin-1 beta (IL-1 beta) *induced* the expression of [intercellular adhesion molecule] ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation ICAM5 TNF 9763522 537120 Additional studies have revealed that LacCer mediates the *induced* nuclear factor-kappaB expression and [intercellular adhesion molecule] ( ICAM-1 ) expression in vascular endothelial cells via the redox dependent transcriptional pathway . Positive_regulation ICAM5 TNF 9830008 551257 We previously demonstrated that and H2O2 differentially *regulate* interleukin-8 (IL-8) and [intercellular adhesion molecule] ( ICAM-1 ) gene expression in endothelial and epithelial cells . Positive_regulation ICOS RORC 20980695 2338694 [ICOS] stimulation *induced* c-MAF , , and T-bet expression in these cells , leading to increased secretion of interleukin-21 (IL-21) , IL-17 , and interferon-? ( IFN-? ) compared with cells stimulated with CD28 . Positive_regulation ICOS TNF 23125331 2740695 We also showed that pDC derived induced ICOS-L expression on pDCs in an autocrine manner and that IL-6 *promoted* [ICOS] expression on T-cells , contributing to the ICOS/ICOS-L mediated T-cell response . Positive_regulation ICOSLG TLR7 15884053 1426486 Further studies reveal that Type I IFN are general suppressors of *mediated* up-regulation of [B7RP-1] . Positive_regulation ICOSLG TNF 11007762 735496 This ligand-receptor pair interacts with a K : ( D ) approximately 33 nM and an off-rate with a t ( ( 1/2 ) ) > 10 min. Interestingly , differentially *regulates* the expression of human [B7RP-1] on B cells , monocytes and dendritic cells ( DC ) . Positive_regulation ICOSLG TNF 11007762 735498 *enhances* [B7RP-1] expression on B cells and monocytes , while it inhibits it on DC . Positive_regulation ICOSLG TNF 11571308 882352 Thus , *induced* [ICOSL] expression seemed to be functionally important for the costimulatory capacity of CD34 ( + ) hematopoietic progenitor cells . Positive_regulation ICOSLG TNF 15618467 1387813 [ICOS ligand] , a B7 family member , is constitutively expressed on B cells , macrophages , and dendritic cells and is *up-regulated* on antigen presenting cells (APCs) and some nonlymphoid tissues by or lipopolysaccharide (LPS) . Positive_regulation ICOSLG TNF 15864782 1426027 IL-1alpha and *induced* [ICOSL] in an NF-kappaB dependent manner on human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation ICOSLG TNF 16221208 1469256 Stimulation with interferon-gamma (IFN-gamma) resulted in increased expression of B7-H1 , whereas [ICOS-L] expression was marginally *increased* upon stimulation with CD40L , with no effect of interleukin ( IL-1 ) , IL-17 , or . Positive_regulation ICOSLG TNF 16552709 1542090 significantly *induced* [B7-H2] and CD40 expression by A549 cells , but had no effect on B7-1 or B7-2 expression . Positive_regulation ICOSLG TNF 16552709 1542092 Monocyte derived in combination with IFN-gamma and LPS markedly *induced* [B7-H2] expression in A549 cells . Positive_regulation ICR1 TNF 17372587 1741387 Intrinsic resistance to *induced* hepatocyte apoptosis in [ICR] mice correlates with expression of a short form of c-FLIP . Positive_regulation ICR3 TNF 17372587 1741388 Intrinsic resistance to *induced* hepatocyte apoptosis in [ICR] mice correlates with expression of a short form of c-FLIP . Positive_regulation ICR4 TNF 17372587 1741389 Intrinsic resistance to *induced* hepatocyte apoptosis in [ICR] mice correlates with expression of a short form of c-FLIP . Positive_regulation ICR5 TNF 17372587 1741390 Intrinsic resistance to *induced* hepatocyte apoptosis in [ICR] mice correlates with expression of a short form of c-FLIP . Positive_regulation ID1 ABL1 16618731 1551061 We show here that expression of the helix-loop-helix transcription factor [Id1] is *enhanced* by in a signal transducer and activator of transcription 5 ( STAT5 ) -dependent manner . Positive_regulation ID1 ABL1 17132628 1686704 Inhibition of by the chemical inhibitor STI571 *resulted* in activation of FOXO3a and down-regulation of [Id1] expression . Positive_regulation ID1 ACVR1 18952055 1989258 Over-expression of ( G356D ) induced phosphorylation of Smad1/5/8 and *activated* [Id1-luc] and alkaline phosphatase activity in myoblasts . Positive_regulation ID1 ACVRL1 17376778 1735405 Although the ALK-5/Smad3 signaling pathway mediated collagen I expression , signaling *mediated* a transient [Id1] up-regulation . Positive_regulation ID1 AKT1 17132628 1686688 Inhibition of activation or growth factor deprivation also *resulted* in strong down-regulation of [Id1] promoter activity , Id1 mRNA , and protein expression . Positive_regulation ID1 AKT1 20796276 2318182 Importantly , Inhibition of *inhibited* [Id1] and integrin a4 expression , resulting in the decreasing biological function of EPCs . Positive_regulation ID1 AKT2 20796276 2318183 Importantly , Inhibition of *inhibited* [Id1] and integrin a4 expression , resulting in the decreasing biological function of EPCs . Positive_regulation ID1 AKT3 20796276 2318184 Importantly , Inhibition of *inhibited* [Id1] and integrin a4 expression , resulting in the decreasing biological function of EPCs . Positive_regulation ID1 ALK 15192043 1280957 Gene silencing of using small interfering RNA also *reduced* DNA synthesis as well as [Id-1] transcription in pphPASMCs regardless of BMP-2 stimulation . Positive_regulation ID1 APC 20195072 2222857 In turn , *triggers* the degradation of the centrosomally localized protein [Id1] and thereby promotes dendrite growth and elaboration . Positive_regulation ID1 APOB 21870248 2501123 Here , we report that [Id1] in human umbilical vascular ECs ( HUVECs ) was *up-regulated* by in a dose- and time dependent manner . Positive_regulation ID1 AR 22819717 2670613 Activation of *induces* [ID1] and promotes hepatocellular carcinoma cell migration and invasion . Positive_regulation ID1 BCR 16618731 1551058 We show here that expression of the helix-loop-helix transcription factor [Id1] is *enhanced* by in a signal transducer and activator of transcription 5 ( STAT5 ) -dependent manner . Positive_regulation ID1 BCR 17132628 1686701 Inhibition of by the chemical inhibitor STI571 *resulted* in activation of FOXO3a and down-regulation of [Id1] expression . Positive_regulation ID1 BMP1 11729207 904362 , but not TGF-beta , strongly *activates* the [Id1] promoter in an Smad dependent manner . Positive_regulation ID1 BMP1 11729207 904451 Whereas SBEs and GGCGCC sequence are critically important , the CAGC and CGCC motifs are needed for efficient *induced* [Id1] promoter activation . Positive_regulation ID1 BMP1 12390958 1001493 *Stimulation* of [Id1] expression by is sufficient and necessary for bone morphogenetic protein induced activation of endothelial cells . Positive_regulation ID1 BMP1 12390958 1001646 [Id1] expression is strongly *induced* by in ECs . Positive_regulation ID1 BMP1 14645520 1172184 Here , we present compelling evidence demonstrating that Smad6 repressed *induced* [Id1] transcription through recruiting transcriptional corepressor C-terminal binding protein (CtBP) . Positive_regulation ID1 BMP1 14656483 1177177 Furthermore , recent studies reveal an important effector function for [Id1] in various *induced* biological responses . Positive_regulation ID1 BMP1 17592024 1764593 In accordance with the effects on cell mitosis , pioglitazone but not fenofibric acid significantly decreased *induced* [Id-1-Luc] activation . Positive_regulation ID1 BMP1 20181926 2242788 Inhibition of signaling in injured skeletal muscle by Noggin injection *reduced* pSmad1/5/8 , [Id1] , and Id3 protein levels . Positive_regulation ID1 BMP1 20181926 2242823 These data suggest a model in which signaling *regulates* [Id1] and Id3 in muscle satellite cells , which directs their proper proliferation before terminal myogenic differentiation after skeletal muscle injury in postnatal animals . Positive_regulation ID1 BMP1 20434519 2282503 Interestingly , FGF-8 enhanced *induced* Smad1/5/8 and [Id-1-promoter] activities with decreased expression of Smad6/7 . Positive_regulation ID1 BMP1 20739564 2313560 Increased signaling *induces* the expression of [Id1-3] along with the inhibition of Atoh1 . Positive_regulation ID1 BMP1 23771884 2828469 The *stimulated* induction of [Id1] and Id3 was markedly reduced in BMPR-II mutant PASMCs and in control PASMCs following siRNA silencing of BMPR-II . Positive_regulation ID1 BMP1 23880664 2849521 It was also revealed that *induced* Smad1/5/8 phosphorylation and [Id-1] expression were suppressed and inhibitory Smad6/7 was induced by kisspeptin . Positive_regulation ID1 BMP10 11729207 904370 , but not TGF-beta , strongly *activates* the [Id1] promoter in an Smad dependent manner . Positive_regulation ID1 BMP10 11729207 904459 Whereas SBEs and GGCGCC sequence are critically important , the CAGC and CGCC motifs are needed for efficient induced [Id1] promoter *activation* . Positive_regulation ID1 BMP10 12390958 1001501 *Stimulation* of [Id1] expression by is sufficient and necessary for bone morphogenetic protein induced activation of endothelial cells . Positive_regulation ID1 BMP10 12390958 1001654 [Id1] expression is strongly *induced* by in ECs . Positive_regulation ID1 BMP10 14645520 1172192 Here , we present compelling evidence demonstrating that Smad6 repressed *induced* [Id1] transcription through recruiting transcriptional corepressor C-terminal binding protein (CtBP) . Positive_regulation ID1 BMP10 14656483 1177185 Furthermore , recent studies reveal an important effector function for [Id1] in various *induced* biological responses . Positive_regulation ID1 BMP10 17592024 1764601 In accordance with the effects on cell mitosis , pioglitazone but not fenofibric acid significantly decreased induced [Id-1-Luc] *activation* . Positive_regulation ID1 BMP10 20181926 2242796 Inhibition of signaling in injured skeletal muscle by Noggin injection *reduced* pSmad1/5/8 , [Id1] , and Id3 protein levels . Positive_regulation ID1 BMP10 20181926 2242831 These data suggest a model in which signaling *regulates* [Id1] and Id3 in muscle satellite cells , which directs their proper proliferation before terminal myogenic differentiation after skeletal muscle injury in postnatal animals . Positive_regulation ID1 BMP10 20434519 2282511 Interestingly , FGF-8 enhanced *induced* Smad1/5/8 and [Id-1-promoter] activities with decreased expression of Smad6/7 . Positive_regulation ID1 BMP10 20739564 2313568 Increased signaling *induces* the expression of [Id1-3] along with the inhibition of Atoh1 . Positive_regulation ID1 BMP10 23771884 2828477 The *stimulated* induction of [Id1] and Id3 was markedly reduced in BMPR-II mutant PASMCs and in control PASMCs following siRNA silencing of BMPR-II . Positive_regulation ID1 BMP10 23880664 2849529 It was also revealed that *induced* Smad1/5/8 phosphorylation and [Id-1] expression were suppressed and inhibitory Smad6/7 was induced by kisspeptin . Positive_regulation ID1 BMP15 11729207 904363 , but not TGF-beta , strongly *activates* the [Id1] promoter in an Smad dependent manner . Positive_regulation ID1 BMP15 11729207 904452 Whereas SBEs and GGCGCC sequence are critically important , the CAGC and CGCC motifs are needed for efficient induced [Id1] promoter *activation* . Positive_regulation ID1 BMP15 12390958 1001494 *Stimulation* of [Id1] expression by is sufficient and necessary for bone morphogenetic protein induced activation of endothelial cells . Positive_regulation ID1 BMP15 12390958 1001647 [Id1] expression is strongly *induced* by in ECs . Positive_regulation ID1 BMP15 14645520 1172185 Here , we present compelling evidence demonstrating that Smad6 repressed *induced* [Id1] transcription through recruiting transcriptional corepressor C-terminal binding protein (CtBP) . Positive_regulation ID1 BMP15 14656483 1177178 Furthermore , recent studies reveal an important effector function for [Id1] in various *induced* biological responses . Positive_regulation ID1 BMP15 17592024 1764594 In accordance with the effects on cell mitosis , pioglitazone but not fenofibric acid significantly decreased *induced* [Id-1-Luc] activation . Positive_regulation ID1 BMP15 20181926 2242789 Inhibition of signaling in injured skeletal muscle by Noggin injection *reduced* pSmad1/5/8 , [Id1] , and Id3 protein levels . Positive_regulation ID1 BMP15 20181926 2242824 These data suggest a model in which signaling *regulates* [Id1] and Id3 in muscle satellite cells , which directs their proper proliferation before terminal myogenic differentiation after skeletal muscle injury in postnatal animals . Positive_regulation ID1 BMP15 20434519 2282504 Interestingly , FGF-8 enhanced *induced* Smad1/5/8 and [Id-1-promoter] activities with decreased expression of Smad6/7 . Positive_regulation ID1 BMP15 20739564 2313561 Increased signaling *induces* the expression of [Id1-3] along with the inhibition of Atoh1 . Positive_regulation ID1 BMP15 23771884 2828470 The stimulated *induction* of [Id1] and Id3 was markedly reduced in BMPR-II mutant PASMCs and in control PASMCs following siRNA silencing of BMPR-II . Positive_regulation ID1 BMP15 23880664 2849522 It was also revealed that *induced* Smad1/5/8 phosphorylation and [Id-1] expression were suppressed and inhibitory Smad6/7 was induced by kisspeptin . Positive_regulation ID1 BMP2 11331769 811980 In telencephalic neuroepithelial cells , *up-regulated* the expression of negative helix-loop-helix ( HLH ) factors [Id1] , Id3 , and Hes-5 ( where Hes is homologue of hairy and Enhancer of Split ) that inhibited the transcriptional activity of neurogenic HLH transcription factors Mash1 and neurogenin . Positive_regulation ID1 BMP2 11729207 904364 , but not TGF-beta , strongly *activates* the [Id1] promoter in an Smad dependent manner . Positive_regulation ID1 BMP2 11729207 904453 Whereas SBEs and GGCGCC sequence are critically important , the CAGC and CGCC motifs are needed for efficient induced [Id1] promoter *activation* . Positive_regulation ID1 BMP2 12296825 990967 *induces* transcription of [Id1] , an inhibitor for myogenesis , within 1 h in the cells . Positive_regulation ID1 BMP2 12390958 1001495 *Stimulation* of [Id1] expression by is sufficient and necessary for bone morphogenetic protein induced activation of endothelial cells . Positive_regulation ID1 BMP2 12390958 1001648 [Id1] expression is strongly *induced* by in ECs . Positive_regulation ID1 BMP2 14645520 1172186 Here , we present compelling evidence demonstrating that Smad6 repressed *induced* [Id1] transcription through recruiting transcriptional corepressor C-terminal binding protein (CtBP) . Positive_regulation ID1 BMP2 14656483 1177179 Furthermore , recent studies reveal an important effector function for [Id1] in various *induced* biological responses . Positive_regulation ID1 BMP2 15192043 1280958 Although [Id-1] response was not *stimulated* by in control PASMCs , the gene delivery of wild-type ALK-6 caused significant increase in the Id-1 transcripts in response to BMP-2 . Positive_regulation ID1 BMP2 15318167 1290553 Transient *induction* of [Id1] by negatively correlates with Mash1 levels . Positive_regulation ID1 BMP2 16247476 1518157 We show that *induces* [Id-1] expression in lung cancer cell lines through its activation of Smad-1/5 , which is dependent on cell culture conditions . Positive_regulation ID1 BMP2 16247476 1518165 In serum-free medium , *induced* significantly less Smad-1/5 activation and [Id-1] expression , and produced significant growth inhibition . Positive_regulation ID1 BMP2 16247476 1518168 Recombinant coinjected with A549 cells , into nude mice increased proliferation and produced an *increase* in [Id-1] expression . Positive_regulation ID1 BMP2 16622178 1589681 Recent data indicate that in a myoblastic cell line and in a breast cancer cell line , *increases* the expression of [Id-1] , a negative regulator of basic helix-loop-helix transcription factors , but the role of BMP-2 stimulated Id-1 expression in the kidney has not been further characterized . Positive_regulation ID1 BMP2 16622178 1589682 Here , we show that *increases* the expression of [Id-1] in differentiated podocytes . Positive_regulation ID1 BMP2 16647687 1557349 Sulfation is required for [Id1] *induction* . Positive_regulation ID1 BMP2 16647687 1557350 We have used sodium chlorate to inhibit sulfation in C2C12 cells and have analyzed *induction* of [Id1] . Positive_regulation ID1 BMP2 16647687 1557351 The inhibition of GAG incorporation into proteoglycans , or their removal by GAG lyases , does not mimic the negative effect on Id1 expression , while sulfation inhibition also represses the Id1-induction exerted by a constitutively active form of the BMP receptor , suggesting that mediated [Id1] *induction* has an intracellular requirement for sulfated molecules . Positive_regulation ID1 BMP2 17592024 1764595 In accordance with the effects on cell mitosis , pioglitazone but not fenofibric acid significantly decreased induced [Id-1-Luc] *activation* . Positive_regulation ID1 BMP2 18381431 1892885 Src was also required for *induced* [Id1] expression and promoter activity , was moderately activated by BMP-2 , and complexed with Smad1/5 . Positive_regulation ID1 BMP2 19918795 2184685 Interestingly , the endoglin knockdown did not alter the level of Smad-1/5/8 phosphorylation induced by BMP-2 , while it suppressed the *induced* expression of [Id1] , a representative BMP-responsive gene . Positive_regulation ID1 BMP2 20181926 2242790 Inhibition of signaling in injured skeletal muscle by Noggin injection *reduced* pSmad1/5/8 , [Id1] , and Id3 protein levels . Positive_regulation ID1 BMP2 20181926 2242825 These data suggest a model in which signaling *regulates* [Id1] and Id3 in muscle satellite cells , which directs their proper proliferation before terminal myogenic differentiation after skeletal muscle injury in postnatal animals . Positive_regulation ID1 BMP2 20434519 2282505 Interestingly , FGF-8 enhanced *induced* Smad1/5/8 and [Id-1-promoter] activities with decreased expression of Smad6/7 . Positive_regulation ID1 BMP2 20638987 2292244 Interestingly , *induced* Smad1/5/8 phosphorylation and [Id-1] promoter activity were enhanced by estradiol pretreatment . Positive_regulation ID1 BMP2 20739564 2313562 Increased signaling *induces* the expression of [Id1-3] along with the inhibition of Atoh1 . Positive_regulation ID1 BMP2 21880603 2486786 Both VEGF and could *induce* the overexpression of [inhibitor of DNA binding 1(Id1)] gene which significantly promoted tube formation in vitro and increase the amount of blood vessels in the Ad-BMP2-BMSC + Ad-VEGF-EPC group after implantation . Positive_regulation ID1 BMP2 21998639 2493724 Thus , *induced* gene expression of [Id1] , Id3 , Dlx2 and Hey1 is endocytosis dependent , whereas BMP-2 induced expression of Id2 , Dlx3 , Zbtb2 and Krt16 is endocytosis independent . Positive_regulation ID1 BMP2 22155034 2542595 Of interest , the BMP-3b suppression of *induced* [Id-1] expression was not observed in cells overexpressing Smad4 molecules . Positive_regulation ID1 BMP2 23771884 2828471 The *stimulated* induction of [Id1] and Id3 was markedly reduced in BMPR-II mutant PASMCs and in control PASMCs following siRNA silencing of BMPR-II . Positive_regulation ID1 BMP2 23880664 2849523 It was also revealed that *induced* Smad1/5/8 phosphorylation and [Id-1] expression were suppressed and inhibitory Smad6/7 was induced by kisspeptin . Positive_regulation ID1 BMP2 23948603 2840886 Further , is *sufficient* to induce [Id1] expression . Positive_regulation ID1 BMP3 11729207 904365 , but not TGF-beta , strongly *activates* the [Id1] promoter in an Smad dependent manner . Positive_regulation ID1 BMP3 11729207 904454 Whereas SBEs and GGCGCC sequence are critically important , the CAGC and CGCC motifs are needed for efficient *induced* [Id1] promoter activation . Positive_regulation ID1 BMP3 12390958 1001496 *Stimulation* of [Id1] expression by is sufficient and necessary for bone morphogenetic protein induced activation of endothelial cells . Positive_regulation ID1 BMP3 12390958 1001649 [Id1] expression is strongly *induced* by in ECs . Positive_regulation ID1 BMP3 14645520 1172187 Here , we present compelling evidence demonstrating that Smad6 repressed *induced* [Id1] transcription through recruiting transcriptional corepressor C-terminal binding protein (CtBP) . Positive_regulation ID1 BMP3 14656483 1177180 Furthermore , recent studies reveal an important effector function for [Id1] in various *induced* biological responses . Positive_regulation ID1 BMP3 17592024 1764596 In accordance with the effects on cell mitosis , pioglitazone but not fenofibric acid significantly decreased *induced* [Id-1-Luc] activation . Positive_regulation ID1 BMP3 20181926 2242791 Inhibition of signaling in injured skeletal muscle by Noggin injection *reduced* pSmad1/5/8 , [Id1] , and Id3 protein levels . Positive_regulation ID1 BMP3 20181926 2242826 These data suggest a model in which signaling *regulates* [Id1] and Id3 in muscle satellite cells , which directs their proper proliferation before terminal myogenic differentiation after skeletal muscle injury in postnatal animals . Positive_regulation ID1 BMP3 20434519 2282506 Interestingly , FGF-8 enhanced *induced* Smad1/5/8 and [Id-1-promoter] activities with decreased expression of Smad6/7 . Positive_regulation ID1 BMP3 20739564 2313563 Increased signaling *induces* the expression of [Id1-3] along with the inhibition of Atoh1 . Positive_regulation ID1 BMP3 23771884 2828472 The stimulated *induction* of [Id1] and Id3 was markedly reduced in BMPR-II mutant PASMCs and in control PASMCs following siRNA silencing of BMPR-II . Positive_regulation ID1 BMP3 23880664 2849524 It was also revealed that *induced* Smad1/5/8 phosphorylation and [Id-1] expression were suppressed and inhibitory Smad6/7 was induced by kisspeptin . Positive_regulation ID1 BMP4 10391928 626867 Besides Id3 , also the [Id1] and Id2 genes were *activated* by in both ES cells and a range of different cell lines . Positive_regulation ID1 BMP4 11729207 904366 , but not TGF-beta , strongly *activates* the [Id1] promoter in an Smad dependent manner . Positive_regulation ID1 BMP4 11729207 904455 Whereas SBEs and GGCGCC sequence are critically important , the CAGC and CGCC motifs are needed for efficient induced [Id1] promoter *activation* . Positive_regulation ID1 BMP4 12390958 1001497 *Stimulation* of [Id1] expression by is sufficient and necessary for bone morphogenetic protein induced activation of endothelial cells . Positive_regulation ID1 BMP4 12390958 1001650 [Id1] expression is strongly *induced* by in ECs . Positive_regulation ID1 BMP4 14645520 1172188 Here , we present compelling evidence demonstrating that Smad6 repressed *induced* [Id1] transcription through recruiting transcriptional corepressor C-terminal binding protein (CtBP) . Positive_regulation ID1 BMP4 14656483 1177181 Furthermore , recent studies reveal an important effector function for [Id1] in various *induced* biological responses . Positive_regulation ID1 BMP4 17592024 1764597 In accordance with the effects on cell mitosis , pioglitazone but not fenofibric acid significantly decreased induced [Id-1-Luc] *activation* . Positive_regulation ID1 BMP4 18372242 1888331 BRC , but not OCT , inhibited *induced* activation of Smad1 ,5,8 phosphorylation and [Id-1] transcription and decreased ALK-3 expression . Positive_regulation ID1 BMP4 18436795 1915406 Mutant cells demonstrated a marked deficiency in *stimulated* [Id1] and Id2 gene and protein expression compared with control cells . Positive_regulation ID1 BMP4 18436795 1915407 Thus , *induced* [Id1] expression was negatively regulated by ERK1/2 activation . Positive_regulation ID1 BMP4 18436795 1915414 Furthermore , activation of ERK1/2 by platelet derived growth factor BB also caused Smad1 linker region phosphorylation and inhibited *induced* [Id1] gene expression . Positive_regulation ID1 BMP4 19422419 2135768 In C2C12 cells , only DRAGON suppressed ALP and [Id1] promoter activities *induced* by or by constitutively activated BMP type I receptors . Positive_regulation ID1 BMP4 20181926 2242792 Inhibition of signaling in injured skeletal muscle by Noggin injection *reduced* pSmad1/5/8 , [Id1] , and Id3 protein levels . Positive_regulation ID1 BMP4 20181926 2242827 These data suggest a model in which signaling *regulates* [Id1] and Id3 in muscle satellite cells , which directs their proper proliferation before terminal myogenic differentiation after skeletal muscle injury in postnatal animals . Positive_regulation ID1 BMP4 20434519 2282507 Interestingly , FGF-8 enhanced *induced* Smad1/5/8 and [Id-1-promoter] activities with decreased expression of Smad6/7 . Positive_regulation ID1 BMP4 20739564 2313564 Increased signaling *induces* the expression of [Id1-3] along with the inhibition of Atoh1 . Positive_regulation ID1 BMP4 21062988 2344906 Similarly , IGF-I suppressed *induced* transcription of the [Id1] , Id2 , and Id3 genes that are crucially involved in prostate tumor progression through PI3K dependent and mTORC1/2 dependent mechanisms . Positive_regulation ID1 BMP4 23701823 2806105 Among the MT1R signaling pathways including AKT , ERK and JNK pathways , inhibition of AKT signaling functionally reversed the MT1R effects on both CRH induced POMC transcription and *induced* [Id-1] transcription . Positive_regulation ID1 BMP4 23771884 2828473 The *stimulated* induction of [Id1] and Id3 was markedly reduced in BMPR-II mutant PASMCs and in control PASMCs following siRNA silencing of BMPR-II . Positive_regulation ID1 BMP4 23880664 2849525 It was also revealed that *induced* Smad1/5/8 phosphorylation and [Id-1] expression were suppressed and inhibitory Smad6/7 was induced by kisspeptin . Positive_regulation ID1 BMP5 11729207 904367 , but not TGF-beta , strongly *activates* the [Id1] promoter in an Smad dependent manner . Positive_regulation ID1 BMP5 11729207 904456 Whereas SBEs and GGCGCC sequence are critically important , the CAGC and CGCC motifs are needed for efficient *induced* [Id1] promoter activation . Positive_regulation ID1 BMP5 12390958 1001498 *Stimulation* of [Id1] expression by is sufficient and necessary for bone morphogenetic protein induced activation of endothelial cells . Positive_regulation ID1 BMP5 12390958 1001651 [Id1] expression is strongly *induced* by in ECs . Positive_regulation ID1 BMP5 14645520 1172189 Here , we present compelling evidence demonstrating that Smad6 repressed *induced* [Id1] transcription through recruiting transcriptional corepressor C-terminal binding protein (CtBP) . Positive_regulation ID1 BMP5 14656483 1177182 Furthermore , recent studies reveal an important effector function for [Id1] in various *induced* biological responses . Positive_regulation ID1 BMP5 17592024 1764598 In accordance with the effects on cell mitosis , pioglitazone but not fenofibric acid significantly decreased *induced* [Id-1-Luc] activation . Positive_regulation ID1 BMP5 20181926 2242793 Inhibition of signaling in injured skeletal muscle by Noggin injection *reduced* pSmad1/5/8 , [Id1] , and Id3 protein levels . Positive_regulation ID1 BMP5 20181926 2242828 These data suggest a model in which signaling *regulates* [Id1] and Id3 in muscle satellite cells , which directs their proper proliferation before terminal myogenic differentiation after skeletal muscle injury in postnatal animals . Positive_regulation ID1 BMP5 20434519 2282508 Interestingly , FGF-8 enhanced *induced* Smad1/5/8 and [Id-1-promoter] activities with decreased expression of Smad6/7 . Positive_regulation ID1 BMP5 20739564 2313565 Increased signaling *induces* the expression of [Id1-3] along with the inhibition of Atoh1 . Positive_regulation ID1 BMP5 23771884 2828474 The stimulated *induction* of [Id1] and Id3 was markedly reduced in BMPR-II mutant PASMCs and in control PASMCs following siRNA silencing of BMPR-II . Positive_regulation ID1 BMP5 23880664 2849526 It was also revealed that *induced* Smad1/5/8 phosphorylation and [Id-1] expression were suppressed and inhibitory Smad6/7 was induced by kisspeptin . Positive_regulation ID1 BMP6 11729207 904368 , but not TGF-beta , strongly *activates* the [Id1] promoter in an Smad dependent manner . Positive_regulation ID1 BMP6 11729207 904457 Whereas SBEs and GGCGCC sequence are critically important , the CAGC and CGCC motifs are needed for efficient induced [Id1] promoter *activation* . Positive_regulation ID1 BMP6 12390958 1001499 *Stimulation* of [Id1] expression by is sufficient and necessary for bone morphogenetic protein induced activation of endothelial cells . Positive_regulation ID1 BMP6 12390958 1001652 [Id1] expression is strongly *induced* by in ECs . Positive_regulation ID1 BMP6 14645520 1172190 Here , we present compelling evidence demonstrating that Smad6 repressed *induced* [Id1] transcription through recruiting transcriptional corepressor C-terminal binding protein (CtBP) . Positive_regulation ID1 BMP6 14656483 1177183 Furthermore , recent studies reveal an important effector function for [Id1] in various *induced* biological responses . Positive_regulation ID1 BMP6 17592024 1764599 In accordance with the effects on cell mitosis , pioglitazone but not fenofibric acid significantly decreased induced [Id-1-Luc] *activation* . Positive_regulation ID1 BMP6 20181926 2242794 Inhibition of signaling in injured skeletal muscle by Noggin injection *reduced* pSmad1/5/8 , [Id1] , and Id3 protein levels . Positive_regulation ID1 BMP6 20181926 2242829 These data suggest a model in which signaling *regulates* [Id1] and Id3 in muscle satellite cells , which directs their proper proliferation before terminal myogenic differentiation after skeletal muscle injury in postnatal animals . Positive_regulation ID1 BMP6 20434519 2282509 Interestingly , FGF-8 enhanced *induced* Smad1/5/8 and [Id-1-promoter] activities with decreased expression of Smad6/7 . Positive_regulation ID1 BMP6 20739564 2313566 Increased signaling *induces* the expression of [Id1-3] along with the inhibition of Atoh1 . Positive_regulation ID1 BMP6 23771884 2828475 The *stimulated* induction of [Id1] and Id3 was markedly reduced in BMPR-II mutant PASMCs and in control PASMCs following siRNA silencing of BMPR-II . Positive_regulation ID1 BMP6 23880664 2849527 It was also revealed that *induced* Smad1/5/8 phosphorylation and [Id-1] expression were suppressed and inhibitory Smad6/7 was induced by kisspeptin . Positive_regulation ID1 BMP7 11729207 904369 , but not TGF-beta , strongly *activates* the [Id1] promoter in an Smad dependent manner . Positive_regulation ID1 BMP7 11729207 904458 Whereas SBEs and GGCGCC sequence are critically important , the CAGC and CGCC motifs are needed for efficient *induced* [Id1] promoter activation . Positive_regulation ID1 BMP7 12390958 1001500 *Stimulation* of [Id1] expression by is sufficient and necessary for bone morphogenetic protein induced activation of endothelial cells . Positive_regulation ID1 BMP7 12390958 1001653 [Id1] expression is strongly *induced* by in ECs . Positive_regulation ID1 BMP7 14645520 1172191 Here , we present compelling evidence demonstrating that Smad6 repressed *induced* [Id1] transcription through recruiting transcriptional corepressor C-terminal binding protein (CtBP) . Positive_regulation ID1 BMP7 14656483 1177184 Furthermore , recent studies reveal an important effector function for [Id1] in various *induced* biological responses . Positive_regulation ID1 BMP7 17592024 1764600 In accordance with the effects on cell mitosis , pioglitazone but not fenofibric acid significantly decreased *induced* [Id-1-Luc] activation . Positive_regulation ID1 BMP7 20181926 2242795 Inhibition of signaling in injured skeletal muscle by Noggin injection *reduced* pSmad1/5/8 , [Id1] , and Id3 protein levels . Positive_regulation ID1 BMP7 20181926 2242830 These data suggest a model in which signaling *regulates* [Id1] and Id3 in muscle satellite cells , which directs their proper proliferation before terminal myogenic differentiation after skeletal muscle injury in postnatal animals . Positive_regulation ID1 BMP7 20434519 2282510 Interestingly , FGF-8 enhanced *induced* Smad1/5/8 and [Id-1-promoter] activities with decreased expression of Smad6/7 . Positive_regulation ID1 BMP7 20739564 2313567 Increased signaling *induces* the expression of [Id1-3] along with the inhibition of Atoh1 . Positive_regulation ID1 BMP7 23771884 2828476 The stimulated *induction* of [Id1] and Id3 was markedly reduced in BMPR-II mutant PASMCs and in control PASMCs following siRNA silencing of BMPR-II . Positive_regulation ID1 BMP7 23880664 2849528 It was also revealed that *induced* Smad1/5/8 phosphorylation and [Id-1] expression were suppressed and inhibitory Smad6/7 was induced by kisspeptin . Positive_regulation ID1 BMPR1A 19726563 2146943 In contrast , TbetaRIII specifically enhanced *mediated* up-regulation of the early response gene [ID-1] . Positive_regulation ID1 BMPR2 20919447 2326930 Tetracycline induced expression significantly *enhanced* the induction of [Id1] , Id3 , and Smad6 mRNA expression in FT293-BMPRII cells treated with BMP2 . Positive_regulation ID1 BMPR2 23771884 2828487 Loss of function *reduces* the induction of Id genes in PASMCs , [Id1] , and Id3 regulate the proliferation of PASMCs via cell cycle inhibition , an effect that may be exacerbated by inflammatory stimuli . Positive_regulation ID1 BRE 23948603 2840885 The Id1 is *necessary* and sufficient for the serum regulation of [Id1] . Positive_regulation ID1 CCND1 15489884 1359460 These data indicate that in mammary epithelial cells , Id1 has cell cycle regulatory functions that are similar to those of c-Myc , and suggest that may be *involved* in [Id1] regulation of cell cycle progression . Positive_regulation ID1 CCND1 18413773 1894194 Id1 overexpression was unable to increase the volume of cyclin D1 ( -/- ) acini , indicating that [Id1] is *dependent* on for its proliferative effects . Positive_regulation ID1 CD79A 16618731 1551059 We show here that expression of the helix-loop-helix transcription factor [Id1] is *enhanced* by in a signal transducer and activator of transcription 5 ( STAT5 ) -dependent manner . Positive_regulation ID1 CD79A 17132628 1686702 Inhibition of by the chemical inhibitor STI571 *resulted* in activation of FOXO3a and down-regulation of [Id1] expression . Positive_regulation ID1 CD79B 16618731 1551060 We show here that expression of the helix-loop-helix transcription factor [Id1] is *enhanced* by in a signal transducer and activator of transcription 5 ( STAT5 ) -dependent manner . Positive_regulation ID1 CD79B 17132628 1686703 Inhibition of by the chemical inhibitor STI571 *resulted* in activation of FOXO3a and down-regulation of [Id1] expression . Positive_regulation ID1 CDC20 20195072 2222856 In turn , *triggers* the degradation of the centrosomally localized protein [Id1] and thereby promotes dendrite growth and elaboration . Positive_regulation ID1 CDKN1A 12016143 942189 We found that [Id-1] expression *induced* phosphorylation of RB and down-regulation of p16(INK4a) but not ( Waf1 ) or p27 ( Kip1 ) . Positive_regulation ID1 CEBPA 22568493 2619210 We have shown that *regulates* [ID1] expression . Positive_regulation ID1 CEBPB 12574125 1057781 The interleukin-3 (IL-3) dependent expression of the [Id-1] gene , encoding a helix-loop-helix ( HLH ) transcriptional inhibitor , is *activated* by both and STAT5 transcription factors bound to its pro-B-cell enhancer (PBE) , but is inhibited by HDAC inhibitors in Ba/F3 cells . Positive_regulation ID1 CEBPB 12574125 1057788 Consistently , expression of an acetylation-resistant mutant of *results* in IL-3 independent expression of the [Id-1] gene . Positive_regulation ID1 CRH 23701823 2806106 Among the MT1R signaling pathways including AKT , ERK and JNK pathways , inhibition of AKT signaling functionally reversed the MT1R effects on both *induced* POMC transcription and BMP-4 induced [Id-1] transcription . Positive_regulation ID1 EGF 21740235 2591551 also *induced* changes in the expression of Id genes [Id1] , Id2 , and Id4 in the SVZ . Positive_regulation ID1 EGFR 21606196 2445807 Here we show that [ID1] is *induced* by nicotinic acetylcholine receptor ( nAChR ) and signaling in a panel of NSCLC cell lines and primary cells from the lung . Positive_regulation ID1 EGR1 17878368 1796992 Id3 is presumably essential for traversal of the beta-selection checkpoint in this context because of the inability of other inhibitor of DNA binding family members to compensate , since transgenic does not *induce* expression of [inhibitor of DNA binding 1 (Id1)] or 2 ( Id2 ) . Positive_regulation ID1 EGR1 21506108 2418461 Induction of [Id-1] by FGF-2 *involves* activity of and sensitizes neuroblastoma cells to cell death . Positive_regulation ID1 ELSPBP1 9235903 445550 S5a thus appears to promote the positive regulation of myogenic genes through ubiquitin independent mechanisms involving inhibition of [Id1] and the *enhancement* of DNA binding by MyoD and . Positive_regulation ID1 FGF2 19477940 2120416 *induced* Id2 , while down regulating [Id1] and Id3 . Positive_regulation ID1 FGF2 21506108 2418462 *Induction* of [Id-1] by involves activity of EGR-1 and sensitizes neuroblastoma cells to cell death . Positive_regulation ID1 FGF2 21506108 2418465 Although regulation of Id-1 protein by several mitogenic factors is well established , little is known about the *role* of in the regulation of [Id-1] . Positive_regulation ID1 FGF8 20434519 2282512 Interestingly , *enhanced* BMP induced Smad1/5/8 and [Id-1-promoter] activities with decreased expression of Smad6/7 . Positive_regulation ID1 GDF2 17068149 1693040 also *activates* the [ID1] promoter derived BMP response element (BRE) in a dose dependent manner ( EC50 = 45 +/- 27 pg/mL ) , and this activation is abolished by silencing ALK1 expression or addition of ALK1 extracellular domain . Positive_regulation ID1 GDF2 22622516 2632466 *induces* both [ID1] and ID3 , and both are necessary for full induction of EphrinB2 . Positive_regulation ID1 GDF2 23807047 2828680 We further investigated the expression of a panel of cancer related genes and found that overexpression increased the phosphorylation of Smad1/5/8 proteins , *increased* the expression of [ID1] , and reduced the expression and activity of matrix metalloproteinase 9 (MMP9) in OS cells . Positive_regulation ID1 GDF5 16716349 1575843 Our results indicate that *induces* [ID1] and ID3 in HUVSMC by a smad dependent , MAPK independent pathway . Positive_regulation ID1 HDAC1 12574125 1057782 The interleukin-3 (IL-3) dependent expression of the [Id-1] gene , encoding a helix-loop-helix ( HLH ) transcriptional inhibitor , is activated by both C/EBPbeta and STAT5 transcription factors bound to its pro-B-cell enhancer (PBE) , but is *inhibited* by inhibitors in Ba/F3 cells . Positive_regulation ID1 HDAC2 12574125 1057783 The interleukin-3 (IL-3) dependent expression of the [Id-1] gene , encoding a helix-loop-helix ( HLH ) transcriptional inhibitor , is activated by both C/EBPbeta and STAT5 transcription factors bound to its pro-B-cell enhancer (PBE) , but is *inhibited* by inhibitors in Ba/F3 cells . Positive_regulation ID1 HGF 15370294 1297358 [Id1] was *up-regulated* by fluvastatin and serum , but not by VEGF and . Positive_regulation ID1 ID2 11316735 806527 In contrast , serum *induces* the expression of [Id1] , , and Id3 . Positive_regulation ID1 ID2 23397264 2809609 This study shows that [Id1] expression in endothelial cells may contribute to angiogenic processes and that increased expression of and Id3 in medulloblastoma is potentially *involved* in tumor cell proliferation and survival . Positive_regulation ID1 ID2 8922523 397168 In the latter , [Id1] and Id3 signals are *detected* in the mesenchyme surrounding the epithelium , whereas is expressed within the epithelium . Positive_regulation ID1 ID2 9779825 540439 Differential expression of Id genes in multipotent myeloid progenitor cells : [Id-1] is *induced* by early-and late acting cytokines while is selectively induced by cytokines that drive terminal granulocytic differentiation . Positive_regulation ID1 ID2 9779825 540440 These data support a cell-cycle regulatory role for [Id-1] in multipotent myeloid progenitor cells and a *role* for during terminal granulocytic differentiation . Positive_regulation ID1 ID3 20881097 2353343 There is selective induction of ID1 and expression in hypoxic pulmonary vascular smooth muscle cells ( VSMCs ) in vivo , and [ID1] and ID3 expression are *increased* by hypoxia in cultured pulmonary VSMCs in a BMP dependent fashion . Positive_regulation ID1 ID3 23397264 2809610 This study shows that [Id1] expression in endothelial cells may contribute to angiogenic processes and that increased expression of Id2 and in medulloblastoma is potentially *involved* in tumor cell proliferation and survival . Positive_regulation ID1 IGF1 12061821 952929 The activated type 1 ( IGF-IR ) *increases* the expression of [Id1] proteins in mouse embryo fibroblasts (MEF) . Positive_regulation ID1 IGF2 12061821 952930 The activated type 1 insulin-like growth factor ( ) *increases* the expression of [Id1] proteins in mouse embryo fibroblasts (MEF) . Positive_regulation ID1 IL3 12574125 1057784 The *dependent* expression of the [Id-1] gene , encoding a helix-loop-helix ( HLH ) transcriptional inhibitor , is activated by both C/EBPbeta and STAT5 transcription factors bound to its pro-B-cell enhancer (PBE) , but is inhibited by HDAC inhibitors in Ba/F3 cells . Positive_regulation ID1 IL3 15905544 1409381 [Id1] expression can be *induced* by in HSC during myeloid differentiation , but not by growth factors that promote erythroid and B cell development . Positive_regulation ID1 IL3 21732357 2538869 Importantly , *induced* inhibitor of DNA binding/differentiation ( [Id)1] in hBMMs , while Id2 were sustained during osteoclast differentiation of mBMMs treated with IL-3 . Positive_regulation ID1 IL6 17322283 1747758 We also found that in vivo *caused* a twofold increase in expression of the BMP signaling target [Id1] and caused increased BMP activity in a luciferase-reporter assay in PA SMC . Positive_regulation ID1 IL6 19224760 2072023 stimulation *caused* uncommitted progenitors to express the [Id1] transcription factor , which is known to inhibit lymphopoiesis and elevate myelopoiesis , and its expression was MAPK dependent . Positive_regulation ID1 MAPK3 18436795 1915408 Thus , BMP4 induced [Id1] expression was negatively *regulated* by activation . Positive_regulation ID1 MCAM 21467165 2428091 Expression of [Id-1] is *regulated* by : a missing link in melanoma progression . Positive_regulation ID1 ME2 16585173 1544119 We further show that [Id-1] expression is negatively *regulated* by <2ME(2)> , which may be an additional mechanism for the antiangiogenic effect of 2ME(2) . Positive_regulation ID1 MYC 15489884 1359459 Inhibition of function by siRNA , antisense oligonucleotides or a dominant repressor *resulted* in downregulation of [Id1] , while ectopic expression of c-Myc resulted in rapid induction of Id1 , suggesting that Id1 may be downstream of c-Myc . Positive_regulation ID1 MYC 22249264 2668240 Saracatinib and dasatinib decreased c-Myc transcriptional repression on miR-29b and led to increased ID1 protein levels , whereas forced expression of repressed miR-29b and *induced* [ID1] . Positive_regulation ID1 MYOG 15322112 1323171 Our findings indicate that induction of [Id1] not only blocks transcriptional activity but also *induces* degradation by blocking formation of myogenin-E47 protein complexes . Positive_regulation ID1 NGF 15361847 1304021 Finally , the treatment of PC12 cells with recombinant Tat also enhanced the *induced* [Id1] expression , further pointing to Id1 as a target for Tat . Positive_regulation ID1 PDLIM7 15064751 1251579 Epstein-Barr virus *upregulates* [Id1] expression in nasopharyngeal epithelial cells . Positive_regulation ID1 PDLIM7 15064751 1251580 With the combination of both specific chemical inhibitors and genetic inhibitors of cell signaling , we showed that *induction* of [Id1] by was dependent on its NF-kappaB activation domain at the carboxy-terminal region , CTAR1 and CTAR2 . Positive_regulation ID1 PDLIM7 15064751 1251581 *Induction* of [Id1] by may facilitate clonal expansion of premalignant nasopharyngeal epithelial cells infected with EBV and may promote their malignant transformation . Positive_regulation ID1 PIK3CA 20796276 2318185 Importantly , Inhibition of *inhibited* [Id1] and integrin a4 expression , resulting in the decreasing biological function of EPCs . Positive_regulation ID1 PIK3R1 20796276 2318186 Importantly , Inhibition of *inhibited* [Id1] and integrin a4 expression , resulting in the decreasing biological function of EPCs . Positive_regulation ID1 PML 18025157 1860583 We show that the [ID1] and ID2 promoters are *activated* by but , unexpectedly , not by wild-type RARalpha/RXR . Positive_regulation ID1 PRDX2 12479699 1024079 also *caused* a decrease in the helix-loop-helix inhibitor of differentiation/DNA binding protein [Id1] , with no change in Id2 levels . Positive_regulation ID1 PRDX2 12479699 1024081 In conclusion , the observed *induced* changes in p21 , Rb , and [Id1] are consistent with cell cycle senescence and differentiation of A2780 ovarian cancer cells . Positive_regulation ID1 RARA 18025157 1860584 We show that the [ID1] and ID2 promoters are *activated* by but , unexpectedly , not by wild-type RARalpha/RXR . Positive_regulation ID1 RBBP4 12574125 1057785 The interleukin-3 (IL-3) dependent expression of the [Id-1] gene , encoding a helix-loop-helix ( HLH ) transcriptional inhibitor , is activated by both C/EBPbeta and STAT5 transcription factors bound to its pro-B-cell enhancer (PBE) , but is *inhibited* by inhibitors in Ba/F3 cells . Positive_regulation ID1 RBBP7 12574125 1057786 The interleukin-3 (IL-3) dependent expression of the [Id-1] gene , encoding a helix-loop-helix ( HLH ) transcriptional inhibitor , is activated by both C/EBPbeta and STAT5 transcription factors bound to its pro-B-cell enhancer (PBE) , but is *inhibited* by inhibitors in Ba/F3 cells . Positive_regulation ID1 SMAD1 11700304 903893 Direct binding of and Smad4 to two distinct motifs *mediates* bone morphogenetic protein-specific transcriptional activation of [Id1] gene . Positive_regulation ID1 SMAD1 12296825 990977 Over-expression of Smad4 , but not , *stimulated* the [Id1] reporter activity and the expression of endogenous Id1 mRNA in Smad4-deficient cells . Positive_regulation ID1 SMAD1 17376778 1735406 Although the ALK-5/Smad3 signaling pathway mediated collagen I expression , signaling *mediated* a transient [Id1] up-regulation . Positive_regulation ID1 SMAD1 17579118 1763955 *dependent* [inhibitor of DNA binding 1] expression and Smad2/3 dependent plasminogen activator inhibitor I expression both were decreased and were accompanied by decreased cell proliferation . Positive_regulation ID1 SMAD1 20830741 2346341 Laser irradiation enhanced *induced* [Id1] reporter activity as well as expression of bone morphogenetic protein (BMP) induced transcription factors such as Id1 , Osterix , and Runx2 . Positive_regulation ID1 SMAD2 19079362 2018272 Our results demonstrate that Smad3 , but not , *mediates* TGF-beta1 dependent early transcriptional induction of [Id1] . Positive_regulation ID1 SMAD2 20830741 2346342 Laser irradiation enhanced *induced* [Id1] reporter activity as well as expression of bone morphogenetic protein (BMP) induced transcription factors such as Id1 , Osterix , and Runx2 . Positive_regulation ID1 SMAD3 19079362 2018273 Our results demonstrate that , but not Smad2 , *mediates* TGF-beta1 dependent early transcriptional induction of [Id1] . Positive_regulation ID1 SMAD3 20830741 2346343 Laser irradiation enhanced *induced* [Id1] reporter activity as well as expression of bone morphogenetic protein (BMP) induced transcription factors such as Id1 , Osterix , and Runx2 . Positive_regulation ID1 SMAD4 11700304 903894 Direct binding of Smad1 and to two distinct motifs *mediates* bone morphogenetic protein-specific transcriptional activation of [Id1] gene . Positive_regulation ID1 SMAD4 12296825 990978 Over-expression of , but not Smad1 , *stimulated* the [Id1] reporter activity and the expression of endogenous Id1 mRNA in Smad4-deficient cells . Positive_regulation ID1 SMAD4 20830741 2346344 Laser irradiation enhanced *induced* [Id1] reporter activity as well as expression of bone morphogenetic protein (BMP) induced transcription factors such as Id1 , Osterix , and Runx2 . Positive_regulation ID1 SMAD5 17376778 1735407 Although the ALK-5/Smad3 signaling pathway mediated collagen I expression , signaling *mediated* a transient [Id1] up-regulation . Positive_regulation ID1 SMAD5 17579118 1763956 *dependent* [inhibitor of DNA binding 1] expression and Smad2/3 dependent plasminogen activator inhibitor I expression both were decreased and were accompanied by decreased cell proliferation . Positive_regulation ID1 SMAD5 20830741 2346345 Laser irradiation enhanced *induced* [Id1] reporter activity as well as expression of bone morphogenetic protein (BMP) induced transcription factors such as Id1 , Osterix , and Runx2 . Positive_regulation ID1 SMAD6 20830741 2346346 Laser irradiation enhanced *induced* [Id1] reporter activity as well as expression of bone morphogenetic protein (BMP) induced transcription factors such as Id1 , Osterix , and Runx2 . Positive_regulation ID1 SMAD6 23880664 2849530 It was also revealed that BMP induced Smad1/5/8 phosphorylation and [Id-1] expression were suppressed and inhibitory was *induced* by kisspeptin . Positive_regulation ID1 SMAD7 20830741 2346347 Laser irradiation enhanced *induced* [Id1] reporter activity as well as expression of bone morphogenetic protein (BMP) induced transcription factors such as Id1 , Osterix , and Runx2 . Positive_regulation ID1 SMAD7 23880664 2849531 It was also revealed that BMP induced Smad1/5/8 phosphorylation and [Id-1] expression were suppressed and inhibitory was *induced* by kisspeptin . Positive_regulation ID1 SMAD9 20830741 2346348 Laser irradiation enhanced *induced* [Id1] reporter activity as well as expression of bone morphogenetic protein (BMP) induced transcription factors such as Id1 , Osterix , and Runx2 . Positive_regulation ID1 SP1 17490644 1750738 Small interfering RNA directed against Sp1 reduced Id-1 expression and the upregulation of the promoter , indicating that is *required* for [Id-1] induction in E47- and Snail expressing cells . Positive_regulation ID1 SRC 18381431 1892886 was also *required* for bone morphogenetic protein-2 (BMP-2) induced [Id1] expression and promoter activity , was moderately activated by BMP-2 , and complexed with Smad1/5 . Positive_regulation ID1 SRC 20709421 2388909 As shown recently , [ID1] is positively *regulated* by the tyrosine kinase in lung carcinoma cell lines and with that appears as a potential new therapeutic target in non-small cell carcinoma ( NSCLC ) . Positive_regulation ID1 SRC 23948603 2840887 Given reports that inhibitors can *block* [Id1] expression , we tested the SRC inhibitor , AZD0530 , and found that it inhibits the serum activation of Id1 . Positive_regulation ID1 SRC 24457967 2907507 Our results show that both the ectopic expression of Cx43 and the inhibition of *reduced* [Id1] , Sox2 expression and promoted the switch from N- to E-cadherin , suggesting that Cx43 , by inhibiting c-Src , downregulates Id1 with the subsequent changes in stem cell phenotype . Positive_regulation ID1 STAT5A 12574125 1057776 *induced* [Id-1] transcription involves recruitment of HDAC1 and deacetylation of C/EBPbeta . Positive_regulation ID1 STAT5A 12574125 1057780 The interleukin-3 (IL-3) dependent expression of the [Id-1] gene , encoding a helix-loop-helix ( HLH ) transcriptional inhibitor , is *activated* by both C/EBPbeta and transcription factors bound to its pro-B-cell enhancer (PBE) , but is inhibited by HDAC inhibitors in Ba/F3 cells . Positive_regulation ID1 TGFB1 17202424 1688833 Overexpression of ILK or inhibition of ILK activity had no effect on [Id1] *induction* by , suggesting that Id1 and ILK have independent roles in epithelial dedifferentiation and EMT . Positive_regulation ID1 TGFB1 19079362 2018269 During our study of the biological function of TGF-beta1 , we found that [Id1] can be strongly *up-regulated* by in the human mammary gland epithelial cell line MCF10A . Positive_regulation ID1 TGFB1 19079362 2018271 Our results demonstrate that Smad3 , but not Smad2 , mediates *dependent* early transcriptional induction of [Id1] . Positive_regulation ID1 TGM2 23877317 2844467 inhibition *attenuates* [ID1] expression in CD44-high glioma initiating cells . Positive_regulation ID1 TGM2 23877317 2844468 Further studies indicated that expression of [inhibitor of DNA binding 1 protein (ID1)] is *regulated* by and might be an important mediator for TGM2 regulated cell proliferation in CD44-high glioma initiating cell lines . Positive_regulation ID1 TGM2 23877317 2844470 *regulates* [ID1] expression in glioma initiating cell lines high in CD44 . Positive_regulation ID1 TMED7 12016143 942190 We found that [Id-1] expression *induced* phosphorylation of RB and down-regulation of p16(INK4a) but not p21 ( Waf1 ) or ( Kip1 ) . Positive_regulation ID1 TP53 16966095 1616072 promotes mitotic exit and *leads* to more extensive [ID1] induction by arsenite . Positive_regulation ID1 TP53 18556654 1946104 Taken together , our study suggests that p53 trans-repressional activity can be mediated by its own target DEC1 and [ID1] is an effector of the *dependent* DNA damage response pathway . Positive_regulation ID1 UBE2V2 17068200 1683980 Furthermore , increased expression *mediates* the [inhibitor of DNA binding 1] proteolysis and promotes DNA repair . Positive_regulation ID1 VEGFA 15370294 1297357 [Id1] was *up-regulated* by fluvastatin and serum , but not by and HGF . Positive_regulation ID1 VEGFA 15494533 1321913 ( VEGF ) and TGFbeta *induced* the expression of [Id1] and Id3 in HUVECs . Positive_regulation ID1 VEGFA 17426247 1723969 Although both the transcript and proteins levels of were *induced* by [Id-1] , only the protein expression of HIF-1alpha was induced without transcriptional changes in both human umbilical endothelial cells and MCF7 breast cancer cells . Positive_regulation ID1 VEGFA 21880603 2486787 Both and BMP2 could *induce* the overexpression of [inhibitor of DNA binding 1(Id1)] gene which significantly promoted tube formation in vitro and increase the amount of blood vessels in the Ad-BMP2-BMSC + Ad-VEGF-EPC group after implantation . Positive_regulation ID1 VEGFA 22139302 2557863 [Id1] was presented at low levels in EPCs , and was rapidly *up-regulated* by stimulation with . Positive_regulation ID1 YY1 12808092 1102307 *represses* the induction of immediate-early genes to TGF-beta and BMP , such as the plasminogen activator inhibitor 1 gene ( PAI-1 ) and the inhibitor of [differentiation/inhibitor of DNA binding 1 gene (Id-1)] . Positive_regulation ID2 CCND1 17559421 1762836 [HSC-T6-Id2-GFP] *increased* cell proliferation with expression . Positive_regulation ID2 ID1 19248835 2079616 Id gene expression was investigated and showed that ( 1 ) [Id2] mRNA expression was upregulated during SMC differentiation without change of Id1 mRNA and ( 2 ) gene expression highly *increased* concomitantly with a decrease of SMC markers while Id2 mRNA was slightly modulated . Positive_regulation ID2 ID1 9779825 540441 These data support a cell-cycle regulatory role for in multipotent myeloid progenitor cells and a *role* for [Id-2] during terminal granulocytic differentiation . Positive_regulation ID2 IL1B 17631285 1787493 *induced* [Id2] gene expression is mediated by Egr-1 in vascular smooth muscle cells . Positive_regulation ID2 IL1B 17631285 1787494 Using Northern- and Western-blot analyses , we documented that *induced* [Id2] gene expression in VSMC in a time- and dose dependent manner . Positive_regulation ID2 IL1B 17631285 1787501 Overexpression of early growth response-1 (Egr-1) in VSMC induced Id2 expression while *induced* [Id2] expression was abrogated in VSMC by the Egr-1 repressor , NGFI-A binding protein 2 (NAB2) , expressed from an adenovirus . Positive_regulation ID2 IL1B 17631285 1787504 Our data demonstrate that *induced* [Id2] expression in VSMC is mediated by the transcription factor Egr-1 in VSMC . Positive_regulation ID2 NES 18287524 1896547 of p204 is *required* for the p204 enhanced cytoplasmic translocation and degradation of [Id2] , because a p204 mutant lacking NES lost these activities . Positive_regulation ID2 TNF 10384879 624984 Significant increases in *induced* [Id2] and Id3 mRNA were observed in the ventricular/subventricular zone , cingulum and corpus callosum . Positive_regulation ID2 TNF 10384879 624985 also *increased* [Id2] mRNA expression in the caudate putamen and hippocampus at the injection site . Positive_regulation ID3 ID1 20881097 2353344 There is selective induction of and ID3 expression in hypoxic pulmonary vascular smooth muscle cells ( VSMCs ) in vivo , and ID1 and [ID3] expression are *increased* by hypoxia in cultured pulmonary VSMCs in a BMP dependent fashion . Positive_regulation IDDM10 CFI 3266138 103084 CH50 , C3 , C4 and significantly *increased* in both [IDDM] and NIDDM compared with non-diabetic healthy controls . Positive_regulation IDDM10 FAS 11321233 807007 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Positive_regulation IDDM10 TNF 10436260 634526 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Positive_regulation IDDM10 TNF 9685802 521719 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Positive_regulation IDDM11 CFI 3266138 103085 CH50 , C3 , C4 and significantly *increased* in both [IDDM] and NIDDM compared with non-diabetic healthy controls . Positive_regulation IDDM11 FAS 11321233 807009 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Positive_regulation IDDM11 TNF 10436260 634527 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Positive_regulation IDDM11 TNF 9685802 521720 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Positive_regulation IDDM12 CFI 3266138 103086 CH50 , C3 , C4 and significantly *increased* in both [IDDM] and NIDDM compared with non-diabetic healthy controls . Positive_regulation IDDM12 FAS 11321233 807011 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Positive_regulation IDDM12 TNF 10436260 634528 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Positive_regulation IDDM12 TNF 9685802 521721 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Positive_regulation IDDM13 CFI 3266138 103087 CH50 , C3 , C4 and significantly *increased* in both [IDDM] and NIDDM compared with non-diabetic healthy controls . Positive_regulation IDDM13 FAS 11321233 807013 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Positive_regulation IDDM13 TNF 10436260 634529 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Positive_regulation IDDM13 TNF 9685802 521722 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Positive_regulation IDDM14 CFI 3266138 103088 CH50 , C3 , C4 and significantly *increased* in both [IDDM] and NIDDM compared with non-diabetic healthy controls . Positive_regulation IDDM14 FAS 11321233 807015 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Positive_regulation IDDM14 TNF 10436260 634530 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Positive_regulation IDDM14 TNF 9685802 521723 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Positive_regulation IDDM15 CFI 3266138 103089 CH50 , C3 , C4 and significantly *increased* in both [IDDM] and NIDDM compared with non-diabetic healthy controls . Positive_regulation IDDM15 FAS 11321233 807017 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Positive_regulation IDDM15 TNF 10436260 634531 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Positive_regulation IDDM15 TNF 9685802 521724 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Positive_regulation IDDM16 CFI 3266138 103090 CH50 , C3 , C4 and significantly *increased* in both [IDDM] and NIDDM compared with non-diabetic healthy controls . Positive_regulation IDDM16 FAS 11321233 807019 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Positive_regulation IDDM16 TNF 10436260 634532 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Positive_regulation IDDM16 TNF 9685802 521725 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Positive_regulation IDDM17 CFI 3266138 103091 CH50 , C3 , C4 and significantly *increased* in both [IDDM] and NIDDM compared with non-diabetic healthy controls . Positive_regulation IDDM17 FAS 11321233 807021 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Positive_regulation IDDM17 TNF 10436260 634533 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Positive_regulation IDDM17 TNF 9685802 521726 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Positive_regulation IDDM18 CFI 3266138 103092 CH50 , C3 , C4 and significantly *increased* in both [IDDM] and NIDDM compared with non-diabetic healthy controls . Positive_regulation IDDM18 FAS 11321233 807023 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Positive_regulation IDDM18 TNF 10436260 634534 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Positive_regulation IDDM18 TNF 9685802 521727 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Positive_regulation IDDM2 CFI 3266138 103093 CH50 , C3 , C4 and significantly *increased* in both [IDDM] and NIDDM compared with non-diabetic healthy controls . Positive_regulation IDDM2 FAS 11321233 807025 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Positive_regulation IDDM2 TNF 10436260 634535 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Positive_regulation IDDM2 TNF 9685802 521728 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Positive_regulation IDDM3 CFI 3266138 103094 CH50 , C3 , C4 and significantly *increased* in both [IDDM] and NIDDM compared with non-diabetic healthy controls . Positive_regulation IDDM3 FAS 11321233 807027 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Positive_regulation IDDM3 TNF 10436260 634536 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Positive_regulation IDDM3 TNF 9685802 521729 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Positive_regulation IDDM4 CFI 3266138 103095 CH50 , C3 , C4 and significantly *increased* in both [IDDM] and NIDDM compared with non-diabetic healthy controls . Positive_regulation IDDM4 FAS 11321233 807029 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Positive_regulation IDDM4 TNF 10436260 634537 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Positive_regulation IDDM4 TNF 9685802 521730 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Positive_regulation IDDM5 CFI 3266138 103096 CH50 , C3 , C4 and significantly *increased* in both [IDDM] and NIDDM compared with non-diabetic healthy controls . Positive_regulation IDDM5 FAS 11321233 807031 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Positive_regulation IDDM5 TNF 10436260 634538 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Positive_regulation IDDM5 TNF 9685802 521731 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Positive_regulation IDDM6 CFI 3266138 103097 CH50 , C3 , C4 and significantly *increased* in both [IDDM] and NIDDM compared with non-diabetic healthy controls . Positive_regulation IDDM6 FAS 11321233 807033 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Positive_regulation IDDM6 TNF 10436260 634539 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Positive_regulation IDDM6 TNF 9685802 521732 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Positive_regulation IDDM7 CFI 3266138 103098 CH50 , C3 , C4 and significantly *increased* in both [IDDM] and NIDDM compared with non-diabetic healthy controls . Positive_regulation IDDM7 FAS 11321233 807035 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Positive_regulation IDDM7 TNF 10436260 634540 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Positive_regulation IDDM7 TNF 9685802 521733 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Positive_regulation IDDM8 CFI 3266138 103099 CH50 , C3 , C4 and significantly *increased* in both [IDDM] and NIDDM compared with non-diabetic healthy controls . Positive_regulation IDDM8 FAS 11321233 807037 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Positive_regulation IDDM8 TNF 10436260 634541 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Positive_regulation IDDM8 TNF 9685802 521734 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Positive_regulation IDDM9 CFI 3266138 103100 CH50 , C3 , C4 and significantly *increased* in both [IDDM] and NIDDM compared with non-diabetic healthy controls . Positive_regulation IDDM9 FAS 11321233 807039 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Positive_regulation IDDM9 TNF 10436260 634542 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Positive_regulation IDDM9 TNF 9685802 521735 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Positive_regulation IDE NES 19584300 2149733 The binding of IDE to either or phosphorylated vimentin *regulates* [IDE] activity differently , depending on the substrate . Positive_regulation IDH2 IL1B 15945434 1416458 *induces* neurological symptoms in [intervertebral disc herniation (IDH)] . Positive_regulation IDO1 IL1B 17030574 1648960 Gamma interferon ( IFN-gamma ) -induced [indoleamine dioxygenase (IDO)] , which inhibits chlamydial replication by reducing the availability of tryptophan , is *up-regulated* by and tumor necrosis factor alpha (TNF-alpha) . Positive_regulation IDO1 TLR7 17725606 1848791 Here we show that the activation of with isRNAs or R848 , a specific ligand for TLR7/8 , can *induce* [IDO] expression in human monocytes , but not in monocyte derived dendritic cells ( moDC ) . Positive_regulation IDO1 TLR7 19353519 2064832 *Induction* of [IDO1] by involved an autocrine interferon (IFN)-beta signaling loop , which was dependent on protein kinase R (PKR) , but independent of IFN-gamma . Positive_regulation IDO1 TLR7 23679126 2805797 stimulation significantly *increased* [IDO] protein level in CD14 ( + ) , CD56 ( + ) , CD1c ( + ) , CD11c ( + ) , and CD123 ( + ) myeloid cells . Positive_regulation IDO1 TNF 10721095 579370 For example we have found that *enhances* IFN-gamma induced [IDO] activity and antimicrobial effect in human glioblastoma cells whereas both IFN-gamma mediated effects were blocked by TNF-alpha as well as by IL-1 in a human uroepithelial cell line . Positive_regulation IDO1 TNF 10805371 691964 Both LPS and *enhanced* [IDO] activity and IDO mRNA expression , with maximal IDO induction at 100 ng/ml LPS or 5 ng/ml TNF-alpha . Positive_regulation IDO1 TNF 10843733 700280 Interferon (IFN)-gamma induced [indoleamine 2,3-dioxygenase (IDO)] activity is *enhanced* synergistically by interleukin (IL-)1 , and LPS in IFN treated macrophages by increasing IDO mRNA concentration . Positive_regulation IDO1 TNF 10843733 700282 These studies demonstrate that IFN treated HeLa cells also exhibit dose dependent enhancement of [IDO] *induction* by and IL-1 , with maximal effects at concentrations of 5 ng/ml and 3 ng/ml , respectively . Positive_regulation IDO1 TNF 11477543 842018 The present study used IFN-gamma or TNF-alpha gene disrupted mice and IFN-gamma antibody treated mice to demonstrate that lipopolysaccharide (LPS) induced systemic [IDO] is largely *dependent* on rather than IFN-gamma . Positive_regulation IDO1 TNF 13678429 1140130 synergistically *enhances* the [IDO] activity induced by IFN-gamma at the level of transcription in human epithelial cells . Positive_regulation IDO1 TNF 15374002 1297908 We found that IFN-gamma induces a strong activation of the tryptophan degrading enzyme indoleamine 2,3-dioxygenase (IDO) and in addition , that the IFN-gamma induced [IDO] activity was enhanced in the *presence* of . Positive_regulation IDO1 TNF 1548034 183784 [INDO] *induced* an approx. two-fold increase in release , but had no effect on IL-1 beta release . Positive_regulation IDO1 TNF 15684619 1370962 In human epithelial cells , interferon-gamma (IFN-gamma) induced [IDO] expression is transcriptionally *enhanced* by . Positive_regulation IDO1 TNF 16426148 1515714 Furthermore , and interleukin-1 (IL-1) synergistically *increase* IFN induced [IDO] activity . Positive_regulation IDO1 TNF 16894392 1632638 The increased production of proinflammatory cytokines such as IL-1beta , or IL-18 resulting from stroke may *lead* to an amplification of the inflammatory process , particularly in limbic areas , and widespread activation of [indoleamine 2,3-dioxygenase (IDO)] and subsequently to depletion of serotonin in paralimbic regions such as the ventral lateral frontal cortex , polar temporal cortex and basal ganglia . Positive_regulation IDO1 TNF 16931033 1627257 Interferon (IFN)-gamma induced expression of [indoleamine 2,3-dioxygenase (IDO)] , an enzyme that inhibits some pathogens by limiting tryptophan availability , is transcriptionally *enhanced* by . Positive_regulation IDO1 TNF 17030574 1648959 Gamma interferon ( IFN-gamma ) -induced [indoleamine dioxygenase (IDO)] , which inhibits chlamydial replication by reducing the availability of tryptophan , is *up-regulated* by interleukin-1beta (IL-1beta) and . Positive_regulation IDO1 TNF 18077563 1834378 Although IDO is strictly an IFN-gamma induced gene product , can synergistically *increase* the transcriptional activation of the [IDO] gene in response to IFN-gamma . Positive_regulation IDO1 TNF 19339614 2056695 Interferon-gamma and *mediate* the upregulation of [indoleamine 2,3-dioxygenase] and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin . Positive_regulation IDO1 TNF 24696473 2949412 These findings indicate that EBV induced [IDO] expression in MDMs is substantially *mediated* by IL-6- and dependent mechanisms via the p38/MAPK and NF-?B pathways , suggesting that a possible role of EBV mediated IDO expression in tumor stroma of NPC may be to create a microenvironment of suppressed T cell immune responses . Positive_regulation IDO1 TNF 24696473 2949414 Instead , EBV induced [IDO] expression in MDMs is substantially *mediated* by IL-6- and dependent mechanisms via the p38/MAPK and NF-?B pathways , which suppressed the proliferation of T cells and impaired the cytotoxic activity of CD8 ( + ) T cells . Positive_regulation IDO2 TNF 19339614 2056694 Interferon-gamma and *mediate* the upregulation of [indoleamine 2,3-dioxygenase] and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin . Positive_regulation IER3 SLC38A3 17704804 1866004 Quantitative real-time PCR and conventional RT-PCR confirmed this *dependent* increase of [IEX-1] expression in Colo320wt cells . Positive_regulation IER3 SLC38A3 17704804 1866008 These observations indicate that the proapoptotic effect of on human colon cancer cells expressing the wild-type CCK2 receptor is *mediated* by [IEX-1] , which modulates NF-kappaB dependent antiapoptotic protection and thereby exerts tumor-suppressive potential . Positive_regulation IER3 TNF 11244505 792324 Here , we show that in HeLa cells *induces* expression of [p22PRG1/IEX-1] in an NF-kappaB dependent fashion . Positive_regulation IER3 TNF 11244505 792327 Blockade of NF-kappaB activation by various NF-kappaB inhibitors abolished *induced* [p22PRG1/IEX-1] expression and increased the sensitivity to apoptosis induced by TNFalpha , an activating Fas-antibody or the anti-cancer drug etoposide . Positive_regulation IER3 TNF 12682234 1077596 LY 294002 , an inhibitor of PI3K , increased [IEX-1S] expression *induced* by and accelerated TNF-alpha induced apoptosis in IkappaB treated Hc cells . Positive_regulation IER3 TNF 12682234 1077600 Overexpression of the dominant negative Akt enhanced , but the constitutively active Akt suppressed , *induced* [IEX-1S] expression , suggesting that PI3K/Akt negatively regulated IEX-1S expression . Positive_regulation IER3 TNF 22417305 2572669 CD4+ CD26- lymphocytes from the peripheral blood of patients with SzS and healthy controls were negatively selected using CD4 and CD26 magnetic beads and analysed for expression of TNFR1 , TNFR2 , [IER3] expression , and ROS production in *response* to at an apoptotic dose . Positive_regulation IER3 TNF 9703517 525444 In support , overexpression of antisense IEX-1L partially blocked *induced* expression of [IEX-1L] and sensitized normal cells to killing . Positive_regulation IFI27 ABL1 11780326 891048 In this model , we showed that the presence of *leads* to elevated levels of [p27kip] in p210BCR/ABL expressing CD34+ cells . Positive_regulation IFI27 ABL1 20200561 2237032 Role of *mediated* [p27kip1] phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors . Positive_regulation IFI27 AHR 15077192 1251855 As shown for TCDD ( dioxin ) , this effect appears to be mediated through the *dependent* expression of [p27] ( KIP1 ) . Positive_regulation IFI27 AKT1 11470779 860345 Expression of dominant negative *increased* [p27] ( kip1 ) protein and resulted in inhibition of CDK2 activity . Positive_regulation IFI27 AKT1 12768542 1094565 Second , ACTH-R triggers cAMP/PKA mediated antimitogenic mechanisms comprised of dephosphorylation/deactivation , c-Myc protein degradation , and [p27] ( Kip1 ) protein *induction* . Positive_regulation IFI27 AKT1 15930366 1414548 Furthermore , ABT-100 inhibited *dependent* [p27] ( Kip1 ) phosphorylation and this event was associated with increased levels of p27 ( Kip1 ) in the nucleus and reduced activity of the cyclin dependent kinase 2 . Positive_regulation IFI27 AKT1 16425184 1540270 signaling *regulates* [p27] ( kip1 ) expression via Skp2 in PC3 and DU145 prostate cancer cells , but is not a major factor in p27 ( kip1 ) regulation in LNCaP and PC346 cells . Positive_regulation IFI27 AKT2 11470779 860346 Expression of dominant negative *increased* [p27] ( kip1 ) protein and resulted in inhibition of CDK2 activity . Positive_regulation IFI27 AKT2 12768542 1094566 Second , ACTH-R triggers cAMP/PKA mediated antimitogenic mechanisms comprised of dephosphorylation/deactivation , c-Myc protein degradation , and [p27] ( Kip1 ) protein *induction* . Positive_regulation IFI27 AKT2 15930366 1414549 Furthermore , ABT-100 inhibited *dependent* [p27] ( Kip1 ) phosphorylation and this event was associated with increased levels of p27 ( Kip1 ) in the nucleus and reduced activity of the cyclin dependent kinase 2 . Positive_regulation IFI27 AKT2 16425184 1540271 signaling *regulates* [p27] ( kip1 ) expression via Skp2 in PC3 and DU145 prostate cancer cells , but is not a major factor in p27 ( kip1 ) regulation in LNCaP and PC346 cells . Positive_regulation IFI27 AKT3 11470779 860347 Expression of dominant negative *increased* [p27] ( kip1 ) protein and resulted in inhibition of CDK2 activity . Positive_regulation IFI27 AKT3 12768542 1094567 Second , ACTH-R triggers cAMP/PKA mediated antimitogenic mechanisms comprised of dephosphorylation/deactivation , c-Myc protein degradation , and [p27] ( Kip1 ) protein *induction* . Positive_regulation IFI27 AKT3 15930366 1414550 Furthermore , ABT-100 inhibited *dependent* [p27] ( Kip1 ) phosphorylation and this event was associated with increased levels of p27 ( Kip1 ) in the nucleus and reduced activity of the cyclin dependent kinase 2 . Positive_regulation IFI27 AKT3 16425184 1540272 signaling *regulates* [p27] ( kip1 ) expression via Skp2 in PC3 and DU145 prostate cancer cells , but is not a major factor in p27 ( kip1 ) regulation in LNCaP and PC346 cells . Positive_regulation IFI27 ANGPT2 11715452 581251 *had* no effect on [P27] expression in both VSMCs and CMs . Positive_regulation IFI27 ARF1 15273726 1296392 We found that antagonized protein kinase B (PKB)/Akt mediated p27Kip1 phosphorylation and *increased* [p27] stability in HER2/neu overexpressing cells . Positive_regulation IFI27 ARF3 15273726 1296393 We found that antagonized protein kinase B (PKB)/Akt mediated p27Kip1 phosphorylation and *increased* [p27] stability in HER2/neu overexpressing cells . Positive_regulation IFI27 ARF4 15273726 1296394 We found that antagonized protein kinase B (PKB)/Akt mediated p27Kip1 phosphorylation and *increased* [p27] stability in HER2/neu overexpressing cells . Positive_regulation IFI27 ARF5 15273726 1296395 We found that antagonized protein kinase B (PKB)/Akt mediated p27Kip1 phosphorylation and *increased* [p27] stability in HER2/neu overexpressing cells . Positive_regulation IFI27 ARF6 15273726 1296396 We found that antagonized protein kinase B (PKB)/Akt mediated p27Kip1 phosphorylation and *increased* [p27] stability in HER2/neu overexpressing cells . Positive_regulation IFI27 BCL10 16467204 1561409 These findings indicate that a Cul4A positively regulates proliferation by targeting p27 for degradation and that Cul4A down-regulation during terminal erythroid differentiation *allows* [p27] to accumulate and signal cell cycle exit . Positive_regulation IFI27 BCL10 18818203 1993558 G0 function of BCL2 and *requires* BAX , BAK , and [p27] phosphorylation by Mirk , revealing a novel role of BAX and BAK in quiescence regulation . Positive_regulation IFI27 BCL2 18818203 1993559 G0 function of BCL2 and *requires* BAX , BAK , and [p27] phosphorylation by Mirk , revealing a novel role of BAX and BAK in quiescence regulation . Positive_regulation IFI27 BCL3 18818203 1993560 G0 function of BCL2 and *requires* BAX , BAK , and [p27] phosphorylation by Mirk , revealing a novel role of BAX and BAK in quiescence regulation . Positive_regulation IFI27 BCL5 18818203 1993555 G0 function of BCL2 and *requires* BAX , BAK , and [p27] phosphorylation by Mirk , revealing a novel role of BAX and BAK in quiescence regulation . Positive_regulation IFI27 BCL6 18818203 1993556 G0 function of BCL2 and *requires* BAX , BAK , and [p27] phosphorylation by Mirk , revealing a novel role of BAX and BAK in quiescence regulation . Positive_regulation IFI27 BCL9 18818203 1993557 G0 function of BCL2 and *requires* BAX , BAK , and [p27] phosphorylation by Mirk , revealing a novel role of BAX and BAK in quiescence regulation . Positive_regulation IFI27 BCR 11704865 879403 We show that stimulation of WEHI 231 cells *results* in down-regulation of cyclin D2 and up-regulation of [p27] ( Kip1 ) , which are associated with pocket protein hypophosphorylation and E2F inactivation . Positive_regulation IFI27 BCR 11780326 891044 In this model , we showed that the presence of *leads* to elevated levels of [p27kip] in p210BCR/ABL expressing CD34+ cells . Positive_regulation IFI27 BCR 20200561 2237029 Role of *mediated* [p27kip1] phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors . Positive_regulation IFI27 BMP1 17114283 1651342 Primary epidermal keratinocytes ( KC ) from TG mice exhibit significantly increased proliferation and decreased p27 ( Kip1 ) expression , compared with WT KC. Alternatively , activation of signaling in HaCaT KC induces growth arrest , *stimulates* [p27] ( Kip1 ) expression , and positively regulates p27 ( Kip1 ) promoter activity , thus further supporting a role of p27 ( Kip1 ) in mediating the effects of BMP signaling on HF size . Positive_regulation IFI27 BMP10 17114283 1651350 Primary epidermal keratinocytes ( KC ) from TG mice exhibit significantly increased proliferation and decreased p27 ( Kip1 ) expression , compared with WT KC. Alternatively , activation of signaling in HaCaT KC induces growth arrest , *stimulates* [p27] ( Kip1 ) expression , and positively regulates p27 ( Kip1 ) promoter activity , thus further supporting a role of p27 ( Kip1 ) in mediating the effects of BMP signaling on HF size . Positive_regulation IFI27 BMP15 17114283 1651343 Primary epidermal keratinocytes ( KC ) from TG mice exhibit significantly increased proliferation and decreased p27 ( Kip1 ) expression , compared with WT KC. Alternatively , activation of signaling in HaCaT KC induces growth arrest , *stimulates* [p27] ( Kip1 ) expression , and positively regulates p27 ( Kip1 ) promoter activity , thus further supporting a role of p27 ( Kip1 ) in mediating the effects of BMP signaling on HF size . Positive_regulation IFI27 BMP2 12850001 1109213 We found a significant accumulation of [p27] ( KIP1 ) in *response* to , whereas the expression level of Skp2 , which is required for ubiquitin dependent p27 ( KIP1 ) degradation , was decreased during this differentiation process . Positive_regulation IFI27 BMP2 17114283 1651344 Primary epidermal keratinocytes ( KC ) from TG mice exhibit significantly increased proliferation and decreased p27 ( Kip1 ) expression , compared with WT KC. Alternatively , activation of signaling in HaCaT KC induces growth arrest , *stimulates* [p27] ( Kip1 ) expression , and positively regulates p27 ( Kip1 ) promoter activity , thus further supporting a role of p27 ( Kip1 ) in mediating the effects of BMP signaling on HF size . Positive_regulation IFI27 BMP3 17114283 1651345 Primary epidermal keratinocytes ( KC ) from TG mice exhibit significantly increased proliferation and decreased p27 ( Kip1 ) expression , compared with WT KC. Alternatively , activation of signaling in HaCaT KC induces growth arrest , *stimulates* [p27] ( Kip1 ) expression , and positively regulates p27 ( Kip1 ) promoter activity , thus further supporting a role of p27 ( Kip1 ) in mediating the effects of BMP signaling on HF size . Positive_regulation IFI27 BMP4 17114283 1651346 Primary epidermal keratinocytes ( KC ) from TG mice exhibit significantly increased proliferation and decreased p27 ( Kip1 ) expression , compared with WT KC. Alternatively , activation of signaling in HaCaT KC induces growth arrest , *stimulates* [p27] ( Kip1 ) expression , and positively regulates p27 ( Kip1 ) promoter activity , thus further supporting a role of p27 ( Kip1 ) in mediating the effects of BMP signaling on HF size . Positive_regulation IFI27 BMP4 19819988 2154606 *induction* of arrest and differentiation of osteoblast-like cells via p21 CIP1 and [p27] KIP1 regulation . Positive_regulation IFI27 BMP5 17114283 1651347 Primary epidermal keratinocytes ( KC ) from TG mice exhibit significantly increased proliferation and decreased p27 ( Kip1 ) expression , compared with WT KC. Alternatively , activation of signaling in HaCaT KC induces growth arrest , *stimulates* [p27] ( Kip1 ) expression , and positively regulates p27 ( Kip1 ) promoter activity , thus further supporting a role of p27 ( Kip1 ) in mediating the effects of BMP signaling on HF size . Positive_regulation IFI27 BMP6 17114283 1651348 Primary epidermal keratinocytes ( KC ) from TG mice exhibit significantly increased proliferation and decreased p27 ( Kip1 ) expression , compared with WT KC. Alternatively , activation of signaling in HaCaT KC induces growth arrest , *stimulates* [p27] ( Kip1 ) expression , and positively regulates p27 ( Kip1 ) promoter activity , thus further supporting a role of p27 ( Kip1 ) in mediating the effects of BMP signaling on HF size . Positive_regulation IFI27 BMP7 17114283 1651349 Primary epidermal keratinocytes ( KC ) from TG mice exhibit significantly increased proliferation and decreased p27 ( Kip1 ) expression , compared with WT KC. Alternatively , activation of signaling in HaCaT KC induces growth arrest , *stimulates* [p27] ( Kip1 ) expression , and positively regulates p27 ( Kip1 ) promoter activity , thus further supporting a role of p27 ( Kip1 ) in mediating the effects of BMP signaling on HF size . Positive_regulation IFI27 CACNA2D3 18588891 1946850 Exogenous expression strongly inhibited cell growth and adhesion and *up-regulated* p21 and [p27] expression in HEK-293T and NUGC4 cells . Positive_regulation IFI27 CAPN1 10749891 698685 Inhibition of by either ALLN or by overexpression of calpastatin *blocks* the degradation of [p27] . Positive_regulation IFI27 CAPN10 10749891 698686 Inhibition of by either ALLN or by overexpression of calpastatin *blocks* the degradation of [p27] . Positive_regulation IFI27 CAPN11 10749891 698687 Inhibition of by either ALLN or by overexpression of calpastatin *blocks* the degradation of [p27] . Positive_regulation IFI27 CAPN12 10749891 698684 Inhibition of by either ALLN or by overexpression of calpastatin *blocks* the degradation of [p27] . Positive_regulation IFI27 CAPN13 10749891 698695 Inhibition of by either ALLN or by overexpression of calpastatin *blocks* the degradation of [p27] . Positive_regulation IFI27 CAPN14 10749891 698696 Inhibition of by either ALLN or by overexpression of calpastatin *blocks* the degradation of [p27] . Positive_regulation IFI27 CAPN15 10749891 698683 Inhibition of by either ALLN or by overexpression of calpastatin *blocks* the degradation of [p27] . Positive_regulation IFI27 CAPN2 10749891 698688 Inhibition of by either ALLN or by overexpression of calpastatin *blocks* the degradation of [p27] . Positive_regulation IFI27 CAPN3 10749891 698689 Inhibition of by either ALLN or by overexpression of calpastatin *blocks* the degradation of [p27] . Positive_regulation IFI27 CAPN5 10749891 698690 Inhibition of by either ALLN or by overexpression of calpastatin *blocks* the degradation of [p27] . Positive_regulation IFI27 CAPN6 10749891 698691 Inhibition of by either ALLN or by overexpression of calpastatin *blocks* the degradation of [p27] . Positive_regulation IFI27 CAPN7 10749891 698692 Inhibition of by either ALLN or by overexpression of calpastatin *blocks* the degradation of [p27] . Positive_regulation IFI27 CAPN8 10749891 698693 Inhibition of by either ALLN or by overexpression of calpastatin *blocks* the degradation of [p27] . Positive_regulation IFI27 CAPN9 10749891 698694 Inhibition of by either ALLN or by overexpression of calpastatin *blocks* the degradation of [p27] . Positive_regulation IFI27 CASP1 12429803 1015055 These findings suggest that ( SKP2 ) is *involved* in Kaposi 's sarcoma progression , not only by promoting the degradation of [p27] ( KIP1 ) but also through other mechanisms still unknown . Positive_regulation IFI27 CASP1 18339899 1904988 These effects are mediated by nuclear accumulation of the [p27] ( Kip1 ) inhibitor *induced* by down-regulation of the ( Skp2 ) and Cks1 proteins , which target p27 ( Kip1 ) for degradation . Positive_regulation IFI27 CASP3 17653085 1858043 This correlates with the HU-induced degradation of the cyclin dependent kinase inhibitors ( CDKI ) p21 and [p27] , *mediated* by the proteasome or . Positive_regulation IFI27 CASP3 23948278 2845348 In parallel , the I/R of CMECs induced G1-phase arrest through [p27] ( Kip1 ) up-regulation and significant *activation* of . Positive_regulation IFI27 CASP9 18652763 1942579 Carnosic acid also augmented these effects when induced by a low ( physiological ) concentration of arsenic trioxide , which was associated with upregulation of [p27] and *activation* of . Positive_regulation IFI27 CAST 12529328 1071063 In good accordance , ectopic expression of the cellular calpain inhibitor *led* to an increase of endogenous [p27] ( Kip1 ) expression . Positive_regulation IFI27 CCL5 21130742 2372795 Cxcl10 , Mx1 , Ifi44 , [Ifi203] , Iigp2 and Rtp4 were dominantly *regulated* by IPS-1 , by TLR3 , and Rsad2 , Mx2 and Cmpk2 were regulated by TLR3 and IPS-1 . Positive_regulation IFI27 CCND1 18710949 1968229 Thus , while PKB dependent p27 phosphorylation appears to increase cyclin D1-Cdk4-p27 assembly or stabilize these complexes in vitro , activation *requires* the tyrosine phosphorylation of [p27] . Positive_regulation IFI27 CCND1 19304953 2064354 Moreover , we demonstrated that the upregulation of AEG-1 could reduce the expression of [p27] ( Kip1 ) and *induce* the expression of through the AKT/FOXO3a pathway . Positive_regulation IFI27 CCND1 20837141 2363746 *regulates* [p27] ( Kip1 ) stability in B cells . Positive_regulation IFI27 CCND1 21312237 2398691 WIN 55,212-2 also upregulated phospho-ERK1/2 , *induced* [Kip1/p27] and Cip1/WAF1/p21 expression , decreased and cyclin E expression , decreased Cdk 2 , Cdk 4 , and Cdk 6 expression levels , and decreased phospho-Rb and E2F-1 expression . Positive_regulation IFI27 CCND1 22460505 2637150 Cell cycle analysis indicated thioridazine induced the down-regulation of , cyclin A and CDK4 , and the *induction* of p21 and [p27] , a cyclin dependent kinase inhibitor . Positive_regulation IFI27 CCNE1 16229012 1517951 Cell cycle progression is facilitated by *dependent* phosphorylation of [p27] on threonine 187 ( T187 ) during late G1 . Positive_regulation IFI27 CCNE1 17144523 1653830 [ Expression of *dependent* kinase [p27] in the low differentiated gastric adenocarcinoma ] . Positive_regulation IFI27 CCNE2 17144523 1653831 [ Expression of *dependent* kinase [p27] in the low differentiated gastric adenocarcinoma ] . Positive_regulation IFI27 CD79A 11704865 879404 We show that stimulation of WEHI 231 cells *results* in down-regulation of cyclin D2 and up-regulation of [p27] ( Kip1 ) , which are associated with pocket protein hypophosphorylation and E2F inactivation . Positive_regulation IFI27 CD79A 11780326 891045 In this model , we showed that the presence of *leads* to elevated levels of [p27kip] in p210BCR/ABL expressing CD34+ cells . Positive_regulation IFI27 CD79A 20200561 2237030 Role of *mediated* [p27kip1] phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors . Positive_regulation IFI27 CD79B 11704865 879405 We show that stimulation of WEHI 231 cells *results* in down-regulation of cyclin D2 and up-regulation of [p27] ( Kip1 ) , which are associated with pocket protein hypophosphorylation and E2F inactivation . Positive_regulation IFI27 CD79B 11780326 891046 In this model , we showed that the presence of *leads* to elevated levels of [p27kip] in p210BCR/ABL expressing CD34+ cells . Positive_regulation IFI27 CD79B 20200561 2237031 Role of *mediated* [p27kip1] phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors . Positive_regulation IFI27 CD8A 21326316 2453078 In vitro polyclonal activation of tolerized ( + ) T cells significantly *increased* [Ifi202b] mRNA expression . Positive_regulation IFI27 CDC7 24511319 2914431 Western blotting showed that there were no apparent changes of protein levels of Cyclin E1 , while [P27] expression significantly declined and the levels of and CDK7 obviously *increased* . Positive_regulation IFI27 CDH1 10023662 590634 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDH10 10023662 590635 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDH11 10023662 590636 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDH12 10023662 590637 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDH13 10023662 590638 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDH15 10023662 590639 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDH16 10023662 590640 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDH17 10023662 590641 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDH18 10023662 590642 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDH19 10023662 590643 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDH2 10023662 590644 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDH20 10023662 590645 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDH22 10023662 590630 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDH23 10023662 590631 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDH24 10023662 590632 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDH26 10023662 590633 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDH3 10023662 590646 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDH4 10023662 590647 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDH5 10023662 590648 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDH6 10023662 590649 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDH7 10023662 590650 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDH8 10023662 590651 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDH9 10023662 590652 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Positive_regulation IFI27 CDK2 16229012 1517952 Cell cycle progression is facilitated by *dependent* phosphorylation of [p27] on threonine 187 ( T187 ) during late G1 . Positive_regulation IFI27 CDK2 16303599 1485513 Recent studies have shown that PGI2 dependent activation of its receptor , IP , inhibits G1 phase progression by blocking the degradation of [p27] and the *activation* of . Positive_regulation IFI27 CDK2 17671428 1780566 Our studies provide evidence that Spy1 expression enhances *dependent* [p27] degradation during late G1 and throughout S-phase . Positive_regulation IFI27 CDK2 21033368 2338890 When the programme decreases the bioenergetics level below certain value the cyclin becomes the *target* for [p27] . Positive_regulation IFI27 CDK2 21312237 2398692 WIN 55,212-2 also upregulated phospho-ERK1/2 , *induced* [Kip1/p27] and Cip1/WAF1/p21 expression , decreased cyclin D1 and cyclin E expression , decreased , Cdk 4 , and Cdk 6 expression levels , and decreased phospho-Rb and E2F-1 expression . Positive_regulation IFI27 CDK2 8822197 384798 These data are consistent with a model wherein cyclin D/CDK complexes sequester the *dependent* kinase inhibitory activity of [p27] . Positive_regulation IFI27 CDK2 9399644 469207 *dependent* phosphorylation of [p27] facilitates its Myc induced release from cyclin E/cdk2 complexes . Positive_regulation IFI27 CDK4 18710949 1968230 Thus , while PKB dependent p27 phosphorylation appears to increase cyclin D1-Cdk4-p27 assembly or stabilize these complexes in vitro , cyclin activation *requires* the tyrosine phosphorylation of [p27] . Positive_regulation IFI27 CDK4 21312237 2398693 WIN 55,212-2 also upregulated phospho-ERK1/2 , *induced* [Kip1/p27] and Cip1/WAF1/p21 expression , decreased cyclin D1 and cyclin E expression , decreased Cdk 2 , , and Cdk 6 expression levels , and decreased phospho-Rb and E2F-1 expression . Positive_regulation IFI27 CDK6 20686221 2299212 Moreover , curcumin *induced* the expression of cyclin dependent kinase inhibitor genes p21 and [p27] , while it inhibited the expression of numerous genes , including Bcl-2 , cyclin D1 , CDK2 , CDK4 and . Positive_regulation IFI27 CDK6 21312237 2398694 WIN 55,212-2 also upregulated phospho-ERK1/2 , *induced* [Kip1/p27] and Cip1/WAF1/p21 expression , decreased cyclin D1 and cyclin E expression , decreased Cdk 2 , Cdk 4 , and expression levels , and decreased phospho-Rb and E2F-1 expression . Positive_regulation IFI27 CDK7 24511319 2914432 Western blotting showed that there were no apparent changes of protein levels of Cyclin E1 , while [P27] expression significantly declined and the levels of CDC7 and obviously *increased* . Positive_regulation IFI27 CDKN1A 20828312 2325254 MeOH extracts reduced the level of topoisomerase IIa but *increased* the level of [p27] ( Kip1 ) , with no significant effect on ( Cip1/waf1 ) . Positive_regulation IFI27 CEBPD 17562792 1762983 Forced expression of inhibits the growth of limbal colonies and *increases* the cell cycle length of primary limbal cells through the activity of [p27] ( Kip1 ) and p57(Kip2) . Positive_regulation IFI27 CEP104 11245420 792547 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP112 11245420 792559 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP120 11245420 792557 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP128 11245420 792545 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP135 11245420 792563 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP152 11245420 792565 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP164 11245420 792564 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP170 11245420 792560 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP19 11245420 792558 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP192 11245420 792550 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP250 11245420 792544 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP290 11245420 792561 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP350 11245420 792546 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP41 11245420 792543 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP44 11245420 792566 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP55 11245420 792542 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP57 11245420 792568 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP63 11245420 792554 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP68 11245420 792562 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP70 11245420 792567 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP72 11245420 792551 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP76 11245420 792552 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP78 11245420 792553 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP85 11245420 792549 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP89 11245420 792555 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP95 11245420 792548 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CEP97 11245420 792556 , a dipeptidyl proteasome inhibitor , *induces* p21WAF1 and [p27KIP1] expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice . Positive_regulation IFI27 CIB1 10995887 733653 These data indicate that the cytoplasmic localization of [p27KIP1] in the process of differentiation is *due* to upregulation of synthesis and subsequent degradation and suggest a role of p27KIP1 in differentiation of neuroblastoma . Positive_regulation IFI27 CIB1 18319192 1886144 Taken together , we hypothesized spinal cord injury stimulated mitogenic signals to *induce* a serine-threonine kinase KIS ( kinase interacting stathmin ) to phosphorylate [p27kip1] on Serine-10 , so that could bind to CRM1 and be exported from nuclei for degradation . Positive_regulation IFI27 CISH 10738115 679645 Interestingly , <9-cis-RA> *induced* transiently the expression of p21 ( Waf1/Cip1 ) , [p27] ( Kip1 ) , p300 , CBP , BAX , Bak and bcl-2 proteins , respectively . Positive_regulation IFI27 CKS1B 11231585 789568 Human , but not other members of the family , reconstitutes ubiquitin ligation of p27 in a completely purified system , binds to Skp2 and greatly *increases* binding of T187 phosphorylated [p27] to Skp2 . Positive_regulation IFI27 CKS1B 14654553 1173924 These findings indicate that , as well as Skp2 , *regulates* the expression level of [p27] protein in gastric carcinomas . Positive_regulation IFI27 COPS5 22350412 2576574 negatively *regulates* [p27] and plays a role in the pathogenesis of nasopharyngeal carcinoma . Positive_regulation IFI27 CTGF 16790529 1590935 *stimulated* the phosphorylation and cytoplasmic translocation of [p27] ( Kip-1 ) on serine 10 . Positive_regulation IFI27 CTGF 16790529 1590936 moreover , addition of the Akt/PKB inhibitor interleukin (IL)-6-hydroxymethyl-chiro-inositol-2 ( R ) -2-methyl-3-O-octadecylcarbonate prevented [p27] ( Kip-1 ) phosphorylation in *response* to . Positive_regulation IFI27 CTTN 20805359 2330624 *regulated* expression of p21 ( WAF1/Cip1 ) and [p27] ( Kip1 ) at the transcriptional and posttranscriptional levels , respectively . Positive_regulation IFI27 CUX2 18223201 1864150 Furthermore , overexpression *induces* high levels of Neurod and [p27] ( Kip1 ) . Positive_regulation IFI27 CXCL10 15988033 1429269 In the characterization of the IP10 induced apoptotic pathway , we found that overexpression of upregulated p53 and *resulted* in altered expression of p53-responsive genes such as the p21Cip1 , [p27kip1] , NF-kappaB , Bax , and PUMA genes and the mitochondrial translocation of Bax . Positive_regulation IFI27 DND1 23890083 2821730 We found that while human *inhibits* miRNA mediated inhibition of [P27] , human APOBEC3G is able to counteract this repression and restore miRNA activity . Positive_regulation IFI27 DNMT1 19037990 2023052 Methylation-specific polymerase chain reaction and bisulfite sequencing showed that the promoter of p16INK4A was methylated in RAF transformed cells , treatment with 5-aza-dC or PD98059 restored the expression of p16INK4A , *increased* p21WAF1 and [p27KIP1] partially , associated with upregulation of the activity of in RAF transformed cell GES-1 , and also decreased the hypermethylation status of p16INK4A , but not all CpG islands of p21WAF1 and p27KIP1 . Positive_regulation IFI27 E2F1 21312237 2398695 WIN 55,212-2 also upregulated phospho-ERK1/2 , *induced* [Kip1/p27] and Cip1/WAF1/p21 expression , decreased cyclin D1 and cyclin E expression , decreased Cdk 2 , Cdk 4 , and Cdk 6 expression levels , and decreased phospho-Rb and expression . Positive_regulation IFI27 E2F1 9096690 422582 Although HL-AS5 and HL-60/V2 cells did not exhibit obvious differences in the phosphorylation status of the retinoblastoma protein ( pRB ) , in complex formation , or in [p27klp1] *induction* following PMA exposure , inhibition of activity of cyclin dependent kinase-2 was attenuated in the antisense expressing line . Positive_regulation IFI27 E2F2 9096690 422583 Although HL-AS5 and HL-60/V2 cells did not exhibit obvious differences in the phosphorylation status of the retinoblastoma protein ( pRB ) , in complex formation , or in [p27klp1] *induction* following PMA exposure , inhibition of activity of cyclin dependent kinase-2 was attenuated in the antisense expressing line . Positive_regulation IFI27 E2F3 9096690 422584 Although HL-AS5 and HL-60/V2 cells did not exhibit obvious differences in the phosphorylation status of the retinoblastoma protein ( pRB ) , in complex formation , or in [p27klp1] *induction* following PMA exposure , inhibition of activity of cyclin dependent kinase-2 was attenuated in the antisense expressing line . Positive_regulation IFI27 E2F4 9096690 422585 Although HL-AS5 and HL-60/V2 cells did not exhibit obvious differences in the phosphorylation status of the retinoblastoma protein ( pRB ) , in complex formation , or in [p27klp1] *induction* following PMA exposure , inhibition of activity of cyclin dependent kinase-2 was attenuated in the antisense expressing line . Positive_regulation IFI27 E2F5 9096690 422586 Although HL-AS5 and HL-60/V2 cells did not exhibit obvious differences in the phosphorylation status of the retinoblastoma protein ( pRB ) , in complex formation , or in [p27klp1] *induction* following PMA exposure , inhibition of activity of cyclin dependent kinase-2 was attenuated in the antisense expressing line . Positive_regulation IFI27 E2F6 9096690 422587 Although HL-AS5 and HL-60/V2 cells did not exhibit obvious differences in the phosphorylation status of the retinoblastoma protein ( pRB ) , in complex formation , or in [p27klp1] *induction* following PMA exposure , inhibition of activity of cyclin dependent kinase-2 was attenuated in the antisense expressing line . Positive_regulation IFI27 E2F7 9096690 422580 Although HL-AS5 and HL-60/V2 cells did not exhibit obvious differences in the phosphorylation status of the retinoblastoma protein ( pRB ) , in complex formation , or in [p27klp1] *induction* following PMA exposure , inhibition of activity of cyclin dependent kinase-2 was attenuated in the antisense expressing line . Positive_regulation IFI27 E2F8 9096690 422581 Although HL-AS5 and HL-60/V2 cells did not exhibit obvious differences in the phosphorylation status of the retinoblastoma protein ( pRB ) , in complex formation , or in [p27klp1] *induction* following PMA exposure , inhibition of activity of cyclin dependent kinase-2 was attenuated in the antisense expressing line . Positive_regulation IFI27 EFS 12551844 1064192 Western blot showed that decreased G1-specific cyclin E expression and *increased* cyclin/cyclin dependent kinase complex inhibitor [p27kipl] expression . Positive_regulation IFI27 EGFR 18575749 1930261 These results suggest that E-cadherin mediated adhesion may be involved in the contact stimulation for cell proliferation in part through the downregulation of [p27] and the *activation* of in human cancers . Positive_regulation IFI27 EGR2 16872830 1613630 Furthermore , mutant *upregulates* cyclin D1 and reduces levels of the cell cycle inhibitor , [p27] . Positive_regulation IFI27 EIF3A 23437357 2744605 Additionally , eIF3a positively regulated proliferation , but negatively regulated cell motility and invasion , which may be due to the *dependent* changes in expression of NDRG1 and [p27] ( kip1 ) observed under these conditions . Positive_regulation IFI27 EPHB2 19538337 2103592 Taken together , these results suggest that melatonin exerts the inhibitory effect of the proliferation of RA-FLSs through the activation of P21 and [P27] *mediated* by . Positive_regulation IFI27 ERBB2 20522955 2271264 In this study , CRA dramatically inhibited expression in a dose- and time dependent manner , effectively inhibited cell proliferation , and *induced* G ( 0 ) /G ( 1 ) arrest through the induction of [p27] ( kip1 ) and cyclin D(1) down-regulation . Positive_regulation IFI27 ESR2 14729654 1198604 inhibits proliferation by repressing c-myc , cyclin D1 , and cyclin A gene transcription , and *increasing* the expression of p21 ( Cip1 ) and [p27] ( Kip1 ) , which leads to a G ( 2 ) cell cycle arrest . Positive_regulation IFI27 EVPL 11780326 891047 In this model , we showed that the presence of *leads* to elevated levels of [p27kip] in p210BCR/ABL expressing CD34+ cells . Positive_regulation IFI27 FGF2 11726615 884483 When the expression level of p27 ( Kip1 ) was determined using immunoblot analysis in the cells treated either with FGF-2 alone or with a concomitant treatment with FGF-2 and cAMP for 24 hours , markedly decreased the p27 ( Kip1 ) level , and cAMP *prevented* the decrease in [p27] ( Kip1 ) level induced by FGF-2 . Positive_regulation IFI27 FGF2 21948550 2497691 Using immunoblotting , the authors showed that *induced* phosphorylation of [p27] at both serine 10 ( Ser10 ) and threonine 187 ( Thr187 ) sites . Positive_regulation IFI27 FLI1 18271016 1911579 In this report , we show that depletion of in Ewing 's cell lines *results* in a senescence phenotype , a marked increase in expression of the G1/S regulatory proteins [p27] ( kip1 ) and p57(kip2) , and a significant decrease in cyclin D1 and CDK2 . Positive_regulation IFI27 FOXA1 17163418 1687962 We have recently identified transcriptional *activation* of [p27] by . Positive_regulation IFI27 FOXO1 15087469 1258119 These studies demonstrate for the first time that can *regulate* [p27kip] nuclear localization . Positive_regulation IFI27 FOXO1 18787071 1986179 Deletion of a 253-bp portion of the 5'-untranslated region ( UTR ) resulted in a significant decrease in *induced* [p27] ( Kip1 ) promoter expression . Positive_regulation IFI27 FOXO1 23077062 2690086 Cdk2 activation was essential for the regenerative OPC response after hypoxia and was accompanied by reduced *dependent* [p27] ( Kip1 ) expression . Positive_regulation IFI27 FOXO3 18256550 1877305 Induced expression of an active form of *resulted* in increased [p27] ( Kip1 ) expression in this cell line . Positive_regulation IFI27 FOXO3 18363870 1951242 Additionally we revealed that activation of could *induce* the accumulation of [p27] ( kip1 ) at protein levels when cell cycle was arrested . Positive_regulation IFI27 FOXO3 18393360 1938293 The inhibition of *mediated* activation of the [p27] gene by the high aberrant expression of c-Myc in many tumor cells likely contributes to their uncontrolled proliferation and invasive phenotype . Positive_regulation IFI27 FOXO3 18787071 1986180 Deletion of a 253-bp portion of the 5'-untranslated region ( UTR ) resulted in a significant decrease in *induced* [p27] ( Kip1 ) promoter expression . Positive_regulation IFI27 FOXO3 18787071 1986186 These data suggest that a putative FOXO regulatory element located in the 5'-UTR of the rat p27 ( Kip1 ) gene plays a role in the age dependent differences in *dependent* [p27] ( Kip1 ) promoter expression . Positive_regulation IFI27 FOXO3 21639915 2450953 Thus , the ( mut ) complex *leads* to elevated [p27kip1] expression and promotes cell cycle arrest . Positive_regulation IFI27 FOXO3 24441545 2922811 Mechanisms in cardiac fibroblast growth : an obligate *role* for Skp2 and in ERK1/2 MAPK dependent regulation of [p27kip1] . Positive_regulation IFI27 FOXO4 18787071 1986181 Deletion of a 253-bp portion of the 5'-untranslated region ( UTR ) resulted in a significant decrease in *induced* [p27] ( Kip1 ) promoter expression . Positive_regulation IFI27 FOXO6 18787071 1986178 Deletion of a 253-bp portion of the 5'-untranslated region ( UTR ) resulted in a significant decrease in *induced* [p27] ( Kip1 ) promoter expression . Positive_regulation IFI27 GATA2 12393444 1007905 These results suggest that may *regulate* expression levels of p21 ( WAF1 ) and [p27] ( Kip1 ) , thereby contributing to the quiescence of hematopoietic stem/progenitor cells . Positive_regulation IFI27 GEM 21477582 2434016 The induction of UBE2M by Gem was accompanied by a reduction in p27 ( Kip1 ) protein levels , which could be restored by silencing UBE2M expression with siRNA or by treating cells with the proteasome inhibitor MG132 , indicating that UBE2M mediates *induced* [p27] ( Kip1 ) protein degradation . Positive_regulation IFI27 GJA1 23313578 2742319 In vitro assays showed that overexpression *increases* the [p27] level with an associated marked decrease of Rb phosphorylation , consistent with the observed blockade of the cell cycle in G0/G1 phase . Positive_regulation IFI27 GRAP2 18022818 1860518 Our study demonstrated that both the functional DRE and the phosphorylation of are *essential* for the induction of p21 and [p27] , resulting in the antiproliferative action of 3MC in HUVECs . Positive_regulation IFI27 HGF 19797611 2183908 Treatment with 1,4-diamino-2,3-dicyano-1,4-bis ( methylthio ) butadiene ( U0126 ) ( an extracellular signal regulated kinase inhibitor ) suppressed the *induced* expression of UGT1A1 and CYP2B6 , as well as p16 , p21 , and [p27] in HepG2 cells . Positive_regulation IFI27 HINT1 19112177 2036811 Increased expression of *increases* cellular levels of [p27] ( KIP1 ) , and HINT1 knockdown with small hairpin RNA leads to decreased cellular levels of p27 ( KIP1 ) . Positive_regulation IFI27 ID3 17404577 1777804 Apart from its effect on the early p27 diminution , appears also *involved* in the control of the steady-state level of [p27] at the G1/S boundary . Positive_regulation IFI27 IFIT3 17050680 1641988 Interestingly , alters JAB1 cellular distribution through interacting with this protein and *increases* the intracellular level of [p27] by preventing it from the JAB-1 dependent and ubiquitin/proteasome mediated degradation . Positive_regulation IFI27 IFNA1 8358738 227636 We demonstrate here that the [p27] gene , which is located in band q32 of human chromosome 14 , is also *induced* by in human cell lines of different origin and that expression is independent of the presence of estradiol receptor in the cells . Positive_regulation IFI27 IFNA10 8358738 227637 We demonstrate here that the [p27] gene , which is located in band q32 of human chromosome 14 , is also *induced* by in human cell lines of different origin and that expression is independent of the presence of estradiol receptor in the cells . Positive_regulation IFI27 IFNA13 8358738 227638 We demonstrate here that the [p27] gene , which is located in band q32 of human chromosome 14 , is also *induced* by in human cell lines of different origin and that expression is independent of the presence of estradiol receptor in the cells . Positive_regulation IFI27 IFNA14 8358738 227639 We demonstrate here that the [p27] gene , which is located in band q32 of human chromosome 14 , is also *induced* by in human cell lines of different origin and that expression is independent of the presence of estradiol receptor in the cells . Positive_regulation IFI27 IFNA16 8358738 227640 We demonstrate here that the [p27] gene , which is located in band q32 of human chromosome 14 , is also *induced* by in human cell lines of different origin and that expression is independent of the presence of estradiol receptor in the cells . Positive_regulation IFI27 IFNA17 8358738 227641 We demonstrate here that the [p27] gene , which is located in band q32 of human chromosome 14 , is also *induced* by in human cell lines of different origin and that expression is independent of the presence of estradiol receptor in the cells . Positive_regulation IFI27 IFNA2 10694472 671333 *Activation* of the human [p27] ( Kip1 ) promoter by . Positive_regulation IFI27 IFNA2 8358738 227642 We demonstrate here that the [p27] gene , which is located in band q32 of human chromosome 14 , is also *induced* by in human cell lines of different origin and that expression is independent of the presence of estradiol receptor in the cells . Positive_regulation IFI27 IFNA21 8358738 227643 We demonstrate here that the [p27] gene , which is located in band q32 of human chromosome 14 , is also *induced* by in human cell lines of different origin and that expression is independent of the presence of estradiol receptor in the cells . Positive_regulation IFI27 IFNA4 8358738 227644 We demonstrate here that the [p27] gene , which is located in band q32 of human chromosome 14 , is also *induced* by in human cell lines of different origin and that expression is independent of the presence of estradiol receptor in the cells . Positive_regulation IFI27 IFNA5 8358738 227645 We demonstrate here that the [p27] gene , which is located in band q32 of human chromosome 14 , is also *induced* by in human cell lines of different origin and that expression is independent of the presence of estradiol receptor in the cells . Positive_regulation IFI27 IFNA6 8358738 227646 We demonstrate here that the [p27] gene , which is located in band q32 of human chromosome 14 , is also *induced* by in human cell lines of different origin and that expression is independent of the presence of estradiol receptor in the cells . Positive_regulation IFI27 IFNA7 8358738 227647 We demonstrate here that the [p27] gene , which is located in band q32 of human chromosome 14 , is also *induced* by in human cell lines of different origin and that expression is independent of the presence of estradiol receptor in the cells . Positive_regulation IFI27 IFNA8 8358738 227648 We demonstrate here that the [p27] gene , which is located in band q32 of human chromosome 14 , is also *induced* by in human cell lines of different origin and that expression is independent of the presence of estradiol receptor in the cells . Positive_regulation IFI27 IGF1 18403485 1925963 In contrast , dependent PI 3-kinase activation was *required* for the increase in cyclin D1 mRNA levels and degradation of [p27] ( Kip1 ) . Positive_regulation IFI27 IL2 20736080 2381294 Similar to the effect of MPA on T cells , MPA inhibited the down-regulation of [p27] on NK cells induced by the incubation of NK cells in the *presence* of . Positive_regulation IFI27 IL3 21423214 2463544 Activation of endogenous JAK2 by *induces* Y88 phosphorylation of [p27] ( Kip1 ) , thus unveiling a novel link between cytokine signaling and cell cycle control in non transformed cells . Positive_regulation IFI27 IL4 10698511 671840 *increased* p21 ( waf1/cip1 ) but not [p27] ( kip1 ) mRNA levels , and stimulated luciferase activity of a p21 ( waf1/cip1 ) promoter-luciferase reporter . Positive_regulation IFI27 IL4 8760794 378145 Stimulation of low density B cells with anti-Ig + *caused* rapid down regulation of the [p27] inhibitor , however this protein was reexpressed at 54-96 h after stimulation . Positive_regulation IFI27 IL6 10198259 605153 *induces* G1 arrest through induction of [p27] ( Kip1 ) , a cyclin dependent kinase inhibitor , and neuron-like morphology in LNCaP prostate tumor cells . Positive_regulation IFI27 IL6 10951574 723752 Inhibition of MEK activation completely abrogated OSM and IL-6 induced p27kip1 accumulation , while expression of dominant negative STAT5 decreased the OSM and mediated inhibition of DNA-synthesis and partially *inhibited* [p27kip1] accumulation . Positive_regulation IFI27 IL6 14764608 1227365 *induces* expression of [Ifi202] , an interferon-inducible candidate gene for lupus susceptibility . Positive_regulation IFI27 IL6 14764608 1227377 We now report that *induces* expression of the [Ifi202] gene . Positive_regulation IFI27 IL7 8847892 386315 Moreover , the growth of JKB2 cells was partially inhibited by TGF beta or , accompanied by decreased CDK4 and CDK6 expression , increased p2l and p27 expression , decreased p27 binding to CDK4/CDK6 , and *increased* binding of [p27] to CDK2 . Positive_regulation IFI27 ILK 12642872 1069477 Inhibition of by a pharmacological inhibitor *results* in inhibition of cell proliferation , PKB/Akt phosphorylation and increase of [p27] ( Kip1 ) . Positive_regulation IFI27 INHBA 17016599 1629957 We report herein that *induced* the expression of [p27KIP1] in CML cells along with the induction of cellular differentiation and apoptosis . Positive_regulation IFI27 IRF5 22116829 2529886 We found that an deficiency in mice decreased the expression of Blimp-1 and *reduced* the expression of the [Ifi202] . Positive_regulation IFI27 JAK2 21423214 2463545 Activation of endogenous by interleukin-3 (IL-3) *induces* Y88 phosphorylation of [p27] ( Kip1 ) , thus unveiling a novel link between cytokine signaling and cell cycle control in non transformed cells . Positive_regulation IFI27 JUN 18374989 1912860 Consistent with the activation of JNK/c-Jun pathway by T cell stimulation , forced expression of in 2B4 T cells and in mouse embryonic fibroblasts ( MEFs ) also *up-regulated* the [Ifi202] expression . Positive_regulation IFI27 JUND 12894219 1117915 Together , our observations support the idea that the transcriptional *activation* of [Ifi202] gene by may be important for the regulation of cell growth and survival . Positive_regulation IFI27 KANK2 21734459 2471770 *regulates* [p27] ( kip1 ) stability and cell migration under metabolic stress . Positive_regulation IFI27 KAT2B 22547391 2637468 We also observed that knockdown of skp2 did not affect the *induced* degradation of [p27] . Positive_regulation IFI27 KHSRP 17603629 1765190 Upregulation of *led* to downregulation of cyclin A , cyclin D1 , cyclin E , cyclin dependent kinase 2 , p-Rb , and PCNA , but to upregulation of Rb and [p27] expressions . Positive_regulation IFI27 KLF4 18559508 1923991 Overexpression of KLF4 also led to significant induction of p27 ( Kip1 ) expression , at both the RNA and protein levels , in a dose- and time dependent manner , indicating that transcriptionally *regulates* the expression of [p27] ( Kip1 ) . Positive_regulation IFI27 KLF4 18559508 1923993 Promoter deletion and point mutation analyses indicated that a region between nucleotides -435 and -60 of the p27 ( Kip1 ) promoter and intact of the three KLF4 binding sites within that region were required for the full *induction* of [p27] ( Kip1 ) promoter activity by . Positive_regulation IFI27 MALT1 16467204 1561408 These findings indicate that a Cul4A positively regulates proliferation by targeting p27 for degradation and that Cul4A down-regulation during terminal erythroid differentiation *allows* [p27] to accumulate and signal cell cycle exit . Positive_regulation IFI27 MAPK1 16020276 1432106 These findings suggest that degradation of [p27] ( KIP1 ) *mediated* by phosphorylation of is correlated with proliferation of the epithelial cells after the extraction of the lens fiber cells . Positive_regulation IFI27 MAPK1 16159599 1455981 In addition , JTT-705 also induced the upregulation of [p27] ( kip1 ) , and this effect was *blocked* by p38 inhibitor . Positive_regulation IFI27 MAPK1 16953232 1682552 RET2A mediated regulation of p18 and [p27] , but not of cyclins D1 and D2 , *requires* functional signaling . Positive_regulation IFI27 MAPK1 18022818 1860519 Our study demonstrated that both the functional DRE and the phosphorylation of are *essential* for the induction of p21 and [p27] , resulting in the antiproliferative action of 3MC in HUVECs . Positive_regulation IFI27 MAPK1 21420505 2427207 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Positive_regulation IFI27 MAPK1 24441545 2922812 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 *dependent* regulation of [p27kip1] . Positive_regulation IFI27 MAPK10 16159599 1455982 In addition , JTT-705 also induced the upregulation of [p27] ( kip1 ) , and this effect was *blocked* by p38 inhibitor . Positive_regulation IFI27 MAPK10 16953232 1682553 RET2A mediated regulation of p18 and [p27] , but not of cyclins D1 and D2 , *requires* functional signaling . Positive_regulation IFI27 MAPK10 18022818 1860520 Our study demonstrated that both the functional DRE and the phosphorylation of are *essential* for the induction of p21 and [p27] , resulting in the antiproliferative action of 3MC in HUVECs . Positive_regulation IFI27 MAPK10 21420505 2427208 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Positive_regulation IFI27 MAPK10 24441545 2922813 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 *dependent* regulation of [p27kip1] . Positive_regulation IFI27 MAPK11 16159599 1455983 In addition , JTT-705 also induced the upregulation of [p27] ( kip1 ) , and this effect was *blocked* by p38 inhibitor . Positive_regulation IFI27 MAPK11 16953232 1682554 RET2A mediated regulation of p18 and [p27] , but not of cyclins D1 and D2 , *requires* functional signaling . Positive_regulation IFI27 MAPK11 18022818 1860521 Our study demonstrated that both the functional DRE and the phosphorylation of are *essential* for the induction of p21 and [p27] , resulting in the antiproliferative action of 3MC in HUVECs . Positive_regulation IFI27 MAPK11 21420505 2427209 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Positive_regulation IFI27 MAPK11 24441545 2922814 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 *dependent* regulation of [p27kip1] . Positive_regulation IFI27 MAPK12 16159599 1455984 In addition , JTT-705 also induced the upregulation of [p27] ( kip1 ) , and this effect was *blocked* by p38 inhibitor . Positive_regulation IFI27 MAPK12 16953232 1682555 RET2A mediated regulation of p18 and [p27] , but not of cyclins D1 and D2 , *requires* functional signaling . Positive_regulation IFI27 MAPK12 18022818 1860522 Our study demonstrated that both the functional DRE and the phosphorylation of are *essential* for the induction of p21 and [p27] , resulting in the antiproliferative action of 3MC in HUVECs . Positive_regulation IFI27 MAPK12 21420505 2427210 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Positive_regulation IFI27 MAPK12 24441545 2922815 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 *dependent* regulation of [p27kip1] . Positive_regulation IFI27 MAPK13 16159599 1455985 In addition , JTT-705 also induced the upregulation of [p27] ( kip1 ) , and this effect was *blocked* by p38 inhibitor . Positive_regulation IFI27 MAPK13 16953232 1682556 RET2A mediated regulation of p18 and [p27] , but not of cyclins D1 and D2 , *requires* functional signaling . Positive_regulation IFI27 MAPK13 18022818 1860523 Our study demonstrated that both the functional DRE and the phosphorylation of are *essential* for the induction of p21 and [p27] , resulting in the antiproliferative action of 3MC in HUVECs . Positive_regulation IFI27 MAPK13 21420505 2427211 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Positive_regulation IFI27 MAPK13 24441545 2922816 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 *dependent* regulation of [p27kip1] . Positive_regulation IFI27 MAPK14 16159599 1455986 In addition , JTT-705 also induced the upregulation of [p27] ( kip1 ) , and this effect was *blocked* by p38 inhibitor . Positive_regulation IFI27 MAPK14 16953232 1682557 RET2A mediated regulation of p18 and [p27] , but not of cyclins D1 and D2 , *requires* functional signaling . Positive_regulation IFI27 MAPK14 18022818 1860524 Our study demonstrated that both the functional DRE and the phosphorylation of are *essential* for the induction of p21 and [p27] , resulting in the antiproliferative action of 3MC in HUVECs . Positive_regulation IFI27 MAPK14 21420505 2427212 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Positive_regulation IFI27 MAPK14 24441545 2922817 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 *dependent* regulation of [p27kip1] . Positive_regulation IFI27 MAPK15 16159599 1455980 In addition , JTT-705 also induced the upregulation of [p27] ( kip1 ) , and this effect was *blocked* by p38 inhibitor . Positive_regulation IFI27 MAPK15 16953232 1682551 RET2A mediated regulation of p18 and [p27] , but not of cyclins D1 and D2 , *requires* functional signaling . Positive_regulation IFI27 MAPK15 18022818 1860517 Our study demonstrated that both the functional DRE and the phosphorylation of are *essential* for the induction of p21 and [p27] , resulting in the antiproliferative action of 3MC in HUVECs . Positive_regulation IFI27 MAPK15 21420505 2427206 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Positive_regulation IFI27 MAPK15 24441545 2922810 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 *dependent* regulation of [p27kip1] . Positive_regulation IFI27 MAPK3 16020276 1432107 These findings suggest that degradation of [p27] ( KIP1 ) *mediated* by phosphorylation of is correlated with proliferation of the epithelial cells after the extraction of the lens fiber cells . Positive_regulation IFI27 MAPK3 16159599 1455987 In addition , JTT-705 also induced the upregulation of [p27] ( kip1 ) , and this effect was *blocked* by p38 inhibitor . Positive_regulation IFI27 MAPK3 16953232 1682558 RET2A mediated regulation of p18 and [p27] , but not of cyclins D1 and D2 , *requires* functional signaling . Positive_regulation IFI27 MAPK3 18022818 1860525 Our study demonstrated that both the functional DRE and the phosphorylation of are *essential* for the induction of p21 and [p27] , resulting in the antiproliferative action of 3MC in HUVECs . Positive_regulation IFI27 MAPK3 18057711 1833791 OR-heparin also inhibited high glucose activated phosphorylation , *induced* [p27] ( Kip1 ) expression , and suppressed reactive oxygen species ( ROS ) accumulation in a dose dependent manner . Positive_regulation IFI27 MAPK3 21312237 2398696 WIN 55,212-2 also upregulated , *induced* [Kip1/p27] and Cip1/WAF1/p21 expression , decreased cyclin D1 and cyclin E expression , decreased Cdk 2 , Cdk 4 , and Cdk 6 expression levels , and decreased phospho-Rb and E2F-1 expression . Positive_regulation IFI27 MAPK3 21420505 2427213 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Positive_regulation IFI27 MAPK3 24441545 2922818 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 *dependent* regulation of [p27kip1] . Positive_regulation IFI27 MAPK3 24441545 2922854 This study sought to probe the mechanisms underlying *mediated* [p27] ( Kip1 ) regulation in mitogenically stimulated cardiac fibroblasts . Positive_regulation IFI27 MAPK4 16159599 1455988 In addition , JTT-705 also induced the upregulation of [p27] ( kip1 ) , and this effect was *blocked* by p38 inhibitor . Positive_regulation IFI27 MAPK4 16953232 1682559 RET2A mediated regulation of p18 and [p27] , but not of cyclins D1 and D2 , *requires* functional signaling . Positive_regulation IFI27 MAPK4 18022818 1860526 Our study demonstrated that both the functional DRE and the phosphorylation of are *essential* for the induction of p21 and [p27] , resulting in the antiproliferative action of 3MC in HUVECs . Positive_regulation IFI27 MAPK4 21420505 2427214 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Positive_regulation IFI27 MAPK4 24441545 2922819 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 *dependent* regulation of [p27kip1] . Positive_regulation IFI27 MAPK6 16159599 1455989 In addition , JTT-705 also induced the upregulation of [p27] ( kip1 ) , and this effect was *blocked* by p38 inhibitor . Positive_regulation IFI27 MAPK6 16953232 1682560 RET2A mediated regulation of p18 and [p27] , but not of cyclins D1 and D2 , *requires* functional signaling . Positive_regulation IFI27 MAPK6 18022818 1860527 Our study demonstrated that both the functional DRE and the phosphorylation of are *essential* for the induction of p21 and [p27] , resulting in the antiproliferative action of 3MC in HUVECs . Positive_regulation IFI27 MAPK6 21420505 2427215 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Positive_regulation IFI27 MAPK6 24441545 2922820 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 *dependent* regulation of [p27kip1] . Positive_regulation IFI27 MAPK7 16159599 1455990 In addition , JTT-705 also induced the upregulation of [p27] ( kip1 ) , and this effect was *blocked* by p38 inhibitor . Positive_regulation IFI27 MAPK7 16953232 1682561 RET2A mediated regulation of p18 and [p27] , but not of cyclins D1 and D2 , *requires* functional signaling . Positive_regulation IFI27 MAPK7 18022818 1860528 Our study demonstrated that both the functional DRE and the phosphorylation of are *essential* for the induction of p21 and [p27] , resulting in the antiproliferative action of 3MC in HUVECs . Positive_regulation IFI27 MAPK7 21420505 2427216 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Positive_regulation IFI27 MAPK7 24441545 2922821 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 *dependent* regulation of [p27kip1] . Positive_regulation IFI27 MAPK8 16159599 1455991 In addition , JTT-705 also induced the upregulation of [p27] ( kip1 ) , and this effect was *blocked* by p38 inhibitor . Positive_regulation IFI27 MAPK8 16953232 1682562 RET2A mediated regulation of p18 and [p27] , but not of cyclins D1 and D2 , *requires* functional signaling . Positive_regulation IFI27 MAPK8 18022818 1860529 Our study demonstrated that both the functional DRE and the phosphorylation of are *essential* for the induction of p21 and [p27] , resulting in the antiproliferative action of 3MC in HUVECs . Positive_regulation IFI27 MAPK8 21420505 2427217 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Positive_regulation IFI27 MAPK8 24441545 2922822 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 *dependent* regulation of [p27kip1] . Positive_regulation IFI27 MAPK9 16159599 1455992 In addition , JTT-705 also induced the upregulation of [p27] ( kip1 ) , and this effect was *blocked* by p38 inhibitor . Positive_regulation IFI27 MAPK9 16953232 1682563 RET2A mediated regulation of p18 and [p27] , but not of cyclins D1 and D2 , *requires* functional signaling . Positive_regulation IFI27 MAPK9 18022818 1860530 Our study demonstrated that both the functional DRE and the phosphorylation of are *essential* for the induction of p21 and [p27] , resulting in the antiproliferative action of 3MC in HUVECs . Positive_regulation IFI27 MAPK9 21420505 2427218 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Positive_regulation IFI27 MAPK9 24441545 2922823 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 *dependent* regulation of [p27kip1] . Positive_regulation IFI27 MAVS 21130742 2372797 Cxcl10 , Mx1 , Ifi44 , [Ifi203] , Iigp2 and Rtp4 were dominantly regulated by IPS-1 , Ccl5 by TLR3 , and Rsad2 , Mx2 and Cmpk2 were *regulated* by TLR3 and . Positive_regulation IFI27 MCL1 23824576 2815886 Changes in expression within NPCs *caused* concomitant changes in the levels of [p27] ( Kip1 ) protein , a key regulator of NPC differentiation . Positive_regulation IFI27 MPC1 24097312 2888732 Inhibitors of MPC , Cytochalasin D and amiloride , decreased P27 mediated uptake of soluble dextran and inhibited P27 induced virus uptake by > 60 % , which provides further evidence that [P27] *induces* . Positive_regulation IFI27 MPC2 24097312 2888733 Inhibitors of MPC , Cytochalasin D and amiloride , decreased P27 mediated uptake of soluble dextran and inhibited P27 induced virus uptake by > 60 % , which provides further evidence that [P27] *induces* . Positive_regulation IFI27 MTOR 20876733 2332020 The molecular basis for the increased brainstem-specific Akt activation in brainstem NSCs is the consequence of differential rictor expression , leading to region-specific *mediated* Akt phosphorylation and Akt regulated [p27] phosphorylation . Positive_regulation IFI27 MUC4 23370366 2754564 expression attenuated Akt activation and decreased the expression of Cyclins D1 and E , but *increased* the expression of p21 and [p27] . Positive_regulation IFI27 MYC 11307151 804392 In culture , activation of *induces* both sequestration of [p27] ( kip1 ) by cyclin D complexes and its subsequent proteolytic degradation . Positive_regulation IFI27 MYC 12768542 1094568 Second , ACTH-R triggers cAMP/PKA mediated antimitogenic mechanisms comprised of Akt/PKB dephosphorylation/deactivation , protein degradation , and [p27] ( Kip1 ) protein *induction* . Positive_regulation IFI27 MYC 15367678 1294783 Adhesion of epithelial cells to the ECM failed to efficiently induce degradation of [p27] , to induce cdk2 activity , or to *induce* and cyclin A synthesis ; Positive_regulation IFI27 MYC 18393360 1938294 The inhibition of FOXO3a mediated *activation* of the [p27] gene by the high aberrant expression of in many tumor cells likely contributes to their uncontrolled proliferation and invasive phenotype . Positive_regulation IFI27 MYC 21245140 2397911 Our data show that SKP2 is a direct MYC target gene and that mediated SKP2 induction *leads* to reduced [p27] levels . Positive_regulation IFI27 MYC 9399644 469211 Activation of *triggers* a rapid induction of cyclin E/cdk2 kinase activity and degradation of [p27] . Positive_regulation IFI27 MYCN 12700651 1082057 *regulates* [p27] levels through an increase in targeting of p27 to the proteasome via cyclin E kinase dependent phosphorylation of p27 and its ubiquitination . Positive_regulation IFI27 MYLIP 21355095 2415654 Furthermore , we provide evidence that indirectly *regulated* [p27] ( kip1 ) protein level by targeting Kip1 ubiquitination promoting complex 1 . Positive_regulation IFI27 MYLIP 24955159 2947292 [P27] expression , other than p57 , was negatively *regulated* by overexpression at post-transcriptional level in HepG2 cells . Positive_regulation IFI27 OPN1MW 15297432 1283404 *induced* [p27] and p53 ( LNCaP only ) protein expression within 6 h and suppressed phosphorylated Akt in both cell lines . Positive_regulation IFI27 OSM 10951574 723753 Inhibition of MEK activation completely abrogated OSM and IL-6 induced p27kip1 accumulation , while expression of dominant negative STAT5 decreased the and IL-6 mediated inhibition of DNA-synthesis and partially *inhibited* [p27kip1] accumulation . Positive_regulation IFI27 PARP2 20393011 2240455 The compound was also able to sensitize U937 cells to TRAIL induced apoptosis through multiple mechanisms : ( i ) activation of caspase-3 and cleavage of *induction* of p21 and [p27] ; Positive_regulation IFI27 PCNA 11063125 746748 Retinoic acid induces neuronal differentiation of embryonal carcinoma cells by reducing proteasome dependent proteolysis of the *dependent* inhibitor [p27] . Positive_regulation IFI27 PCNA 15073847 1232825 The essential *role* of in Skp2 dependent [p27] degradation was recently discovered , but its role in human malignancies is unknown . Positive_regulation IFI27 PCNA 15367678 1294784 Adhesion of epithelial cells to the ECM failed to efficiently induce degradation of [p27] , to induce cdk2 activity , or to *induce* Myc and A synthesis ; Positive_regulation IFI27 PCNA 15924242 1445835 Effect of the *dependent* kinases inhibitor [p27] on resistance of ovarian cancer multicellular spheroids to anticancer chemotherapy . Positive_regulation IFI27 PCNA 20186868 2222774 Western blot analysis on DU145 cells treated with compounds 7 and 9 demonstrated that 7-azaisoindigo derivatives could decrease the level of CDK2 activity ( phosphorylation ) and the expression of cyclin D1 , and increase the expression of endogenous *dependent* inhibitor [p27] . Positive_regulation IFI27 PCNA 21312237 2398697 WIN 55,212-2 also upregulated phospho-ERK1/2 , *induced* [Kip1/p27] and Cip1/WAF1/p21 expression , decreased cyclin D1 and E expression , decreased Cdk 2 , Cdk 4 , and Cdk 6 expression levels , and decreased phospho-Rb and E2F-1 expression . Positive_regulation IFI27 PDGFB 12171790 974228 Our data suggest that IL-1beta may promote SMC proliferation after vascular injury and in atherogenesis by suppression of *induced* p21 and [p27] . Positive_regulation IFI27 PHOX2A 19564421 2122048 Employing serine-to-alanine and serine-to-aspartic acid Phox2a substitution mutants expressed in inducible CAD cell lines , we demonstrated that the transcriptional activity of Phox2a is regulated by two sequential cAMP dependent events : first , cAMP signaling promotes dephosphorylation of Phox2a in at least one site , Ser206 , thereby allowing to bind DNA and *initiate* [p27] ( Kip1 ) transcription ; Positive_regulation IFI27 PI3 18403485 1925964 In contrast , IGF-I dependent activation was *required* for the increase in cyclin D1 mRNA levels and degradation of [p27] ( Kip1 ) . Positive_regulation IFI27 PIK3CA 11593401 869841 This was because reduced activity *lead* to proteolytic degradation of [p27] . Positive_regulation IFI27 PIK3CA 16425184 1540273 signaling *regulates* [p27] ( kip1 ) expression via Skp2 in PC3 and DU145 prostate cancer cells , but is not a major factor in p27 ( kip1 ) regulation in LNCaP and PC346 cells . Positive_regulation IFI27 PIK3R1 11593401 869842 This was because reduced activity *lead* to proteolytic degradation of [p27] . Positive_regulation IFI27 PIK3R1 16425184 1540274 signaling *regulates* [p27] ( kip1 ) expression via Skp2 in PC3 and DU145 prostate cancer cells , but is not a major factor in p27 ( kip1 ) regulation in LNCaP and PC346 cells . Positive_regulation IFI27 PIM1 20639905 2329285 The lower level of *induces* an increase in the cell cycle inhibitor [p27] ( Kip1 ) and blocks cell proliferation even in the absence of p53 . Positive_regulation IFI27 POLDIP2 16159599 1455979 In addition , JTT-705 also induced the upregulation of [p27] ( kip1 ) , and this effect was *blocked* by MAPK inhibitor . Positive_regulation IFI27 PPARD 19587222 2111800 mediated [p21/p27] *induction* via increased CREB binding protein nuclear translocation in beraprost induced antiproliferation of murine aortic smooth muscle cells . Positive_regulation IFI27 PPARD 19587222 2111805 Herein , we demonstrate for the first time that BPS mediated activation *enhances* transcriptional activation of [p21/p27] by increasing CBP nuclear translocation , which contributes to the vasoprotective action of BPS . Positive_regulation IFI27 PPARG 12694805 1080890 Mitogen induced downregulation of the cyclin dependent kinase (CDK) inhibitor [p27] ( kip1 ) , and induction of the G1 cyclins cyclin D1 , cyclin A , and cyclin E were also *attenuated* by the non-thiazolidinedione partial agonist . Positive_regulation IFI27 PPARG 16374840 1505309 Troglitazone mediated activation also suppressed COX-2 expression and *induced* [p27] in HCC cells . Positive_regulation IFI27 PPP2CA 20954073 2333478 In addition , ceramide stimulated binding of the PP2A catalytic subunit PP2A-Caß to Akt as assessed by immunoprecipitation experiments , indicating that is *involved* in the induction of [p27] ( kip1 ) via inhibition of Akt pathway . Positive_regulation IFI27 PPP2R1A 20954073 2333479 In addition , ceramide stimulated binding of the PP2A catalytic subunit PP2A-Caß to Akt as assessed by immunoprecipitation experiments , indicating that is *involved* in the induction of [p27] ( kip1 ) via inhibition of Akt pathway . Positive_regulation IFI27 PPP2R2B 20954073 2333480 In addition , ceramide stimulated binding of the PP2A catalytic subunit PP2A-Caß to Akt as assessed by immunoprecipitation experiments , indicating that is *involved* in the induction of [p27] ( kip1 ) via inhibition of Akt pathway . Positive_regulation IFI27 PRDM1 22116829 2529893 Moreover , expression *increased* the expression of [Ifi202] , whereas it reduced the expression of Aim2 . Positive_regulation IFI27 PRDX2 12508652 1027495 Expression patterns of accumulation of highly acetylated histone H3 , H4; p53 and cell cycle associated p21waf , [p27] which were *induced* by were determined by using Western blot analysis . Positive_regulation IFI27 PRKAA1 18701472 1950381 Cytoplasmic localization of p27 in Tsc2-null cells was reversible pharmacologically using inhibitors of the LKB1/AMPK pathway , and localization of [p27] to the cytoplasm could be *induced* directly by activating AMPK physiologically ( glucose deprivation ) or genetically ( constitutively active ) in Tsc2-proficient cells . Positive_regulation IFI27 PRKAA1 18927218 2028673 The chemical activator of AMPK ( 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside , 0.5 mm ) increased the cell cycle inhibitor p27 kip expression significantly , whereas the inhibitor ( compound C , 20 microm ) and FSH *reduced* [p27kip] expression significantly compared with control . Positive_regulation IFI27 PRKAA1 20146253 2242347 *mediated* phosphorylation of murine [p27] at T197 promotes binding of 14-3-3 proteins and increases p27 stability . Positive_regulation IFI27 PRKAA2 18701472 1950382 Cytoplasmic localization of p27 in Tsc2-null cells was reversible pharmacologically using inhibitors of the LKB1/AMPK pathway , and localization of [p27] to the cytoplasm could be *induced* directly by activating AMPK physiologically ( glucose deprivation ) or genetically ( constitutively active ) in Tsc2-proficient cells . Positive_regulation IFI27 PRKAA2 18927218 2028674 The chemical activator of AMPK ( 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside , 0.5 mm ) increased the cell cycle inhibitor p27 kip expression significantly , whereas the inhibitor ( compound C , 20 microm ) and FSH *reduced* [p27kip] expression significantly compared with control . Positive_regulation IFI27 PRKAA2 20146253 2242348 *mediated* phosphorylation of murine [p27] at T197 promotes binding of 14-3-3 proteins and increases p27 stability . Positive_regulation IFI27 PRKAB1 18701472 1950383 Cytoplasmic localization of p27 in Tsc2-null cells was reversible pharmacologically using inhibitors of the LKB1/AMPK pathway , and localization of [p27] to the cytoplasm could be *induced* directly by activating AMPK physiologically ( glucose deprivation ) or genetically ( constitutively active ) in Tsc2-proficient cells . Positive_regulation IFI27 PRKAB1 18927218 2028675 The chemical activator of AMPK ( 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside , 0.5 mm ) increased the cell cycle inhibitor p27 kip expression significantly , whereas the inhibitor ( compound C , 20 microm ) and FSH *reduced* [p27kip] expression significantly compared with control . Positive_regulation IFI27 PRKAB1 20146253 2242349 *mediated* phosphorylation of murine [p27] at T197 promotes binding of 14-3-3 proteins and increases p27 stability . Positive_regulation IFI27 PRKAB2 18701472 1950384 Cytoplasmic localization of p27 in Tsc2-null cells was reversible pharmacologically using inhibitors of the LKB1/AMPK pathway , and localization of [p27] to the cytoplasm could be *induced* directly by activating AMPK physiologically ( glucose deprivation ) or genetically ( constitutively active ) in Tsc2-proficient cells . Positive_regulation IFI27 PRKAB2 18927218 2028676 The chemical activator of AMPK ( 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside , 0.5 mm ) increased the cell cycle inhibitor p27 kip expression significantly , whereas the inhibitor ( compound C , 20 microm ) and FSH *reduced* [p27kip] expression significantly compared with control . Positive_regulation IFI27 PRKAB2 20146253 2242350 *mediated* phosphorylation of murine [p27] at T197 promotes binding of 14-3-3 proteins and increases p27 stability . Positive_regulation IFI27 PRKACB 12146978 969846 ACTH promotion of [p27] ( Kip1 ) induction in mouse Y1 adrenocortical tumor cells is *dependent* on both activation and Akt/PKB inactivation . Positive_regulation IFI27 PRKACG 12146978 969847 ACTH promotion of [p27] ( Kip1 ) induction in mouse Y1 adrenocortical tumor cells is *dependent* on both activation and Akt/PKB inactivation . Positive_regulation IFI27 PRKAG1 18701472 1950385 Cytoplasmic localization of p27 in Tsc2-null cells was reversible pharmacologically using inhibitors of the LKB1/AMPK pathway , and localization of [p27] to the cytoplasm could be *induced* directly by activating AMPK physiologically ( glucose deprivation ) or genetically ( constitutively active ) in Tsc2-proficient cells . Positive_regulation IFI27 PRKAG1 18927218 2028677 The chemical activator of AMPK ( 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside , 0.5 mm ) increased the cell cycle inhibitor p27 kip expression significantly , whereas the inhibitor ( compound C , 20 microm ) and FSH *reduced* [p27kip] expression significantly compared with control . Positive_regulation IFI27 PRKAG1 20146253 2242351 *mediated* phosphorylation of murine [p27] at T197 promotes binding of 14-3-3 proteins and increases p27 stability . Positive_regulation IFI27 PRKAG2 18701472 1950386 Cytoplasmic localization of p27 in Tsc2-null cells was reversible pharmacologically using inhibitors of the LKB1/AMPK pathway , and localization of [p27] to the cytoplasm could be *induced* directly by activating AMPK physiologically ( glucose deprivation ) or genetically ( constitutively active ) in Tsc2-proficient cells . Positive_regulation IFI27 PRKAG2 18927218 2028678 The chemical activator of AMPK ( 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside , 0.5 mm ) increased the cell cycle inhibitor p27 kip expression significantly , whereas the inhibitor ( compound C , 20 microm ) and FSH *reduced* [p27kip] expression significantly compared with control . Positive_regulation IFI27 PRKAG2 20146253 2242352 *mediated* phosphorylation of murine [p27] at T197 promotes binding of 14-3-3 proteins and increases p27 stability . Positive_regulation IFI27 PRKAR1A 12146978 969848 ACTH promotion of [p27] ( Kip1 ) induction in mouse Y1 adrenocortical tumor cells is *dependent* on both activation and Akt/PKB inactivation . Positive_regulation IFI27 PRKAR1B 12146978 969849 ACTH promotion of [p27] ( Kip1 ) induction in mouse Y1 adrenocortical tumor cells is *dependent* on both activation and Akt/PKB inactivation . Positive_regulation IFI27 PRKAR2A 12146978 969850 ACTH promotion of [p27] ( Kip1 ) induction in mouse Y1 adrenocortical tumor cells is *dependent* on both activation and Akt/PKB inactivation . Positive_regulation IFI27 PRKAR2B 12146978 969851 ACTH promotion of [p27] ( Kip1 ) induction in mouse Y1 adrenocortical tumor cells is *dependent* on both activation and Akt/PKB inactivation . Positive_regulation IFI27 PTBP1 15684381 1370896 12-O-Tetradecanoylphorbol-13-acetate ( TPA ) -induced differentiation in HL60 cells was used to examine *induced* modulation of [p27] ( Kip1 ) protein synthesis during differentiation . Positive_regulation IFI27 PTGS2 21553651 2429327 PDE4 inhibitor suppresses PGE2 induced osteoclast formation via *mediated* [p27] ( KIP1 ) expression in RAW264.7 cells . Positive_regulation IFI27 PTGS2 21553651 2429328 Taken together , our data demonstrate that the PDE4 inhibitor enhances PGE2 induced growth arrest of osteoclast precursors via *mediated* [p27] ( KIP1 ) expression , which in turn negatively regulates osteoclast formation . Positive_regulation IFI27 QKI 21768773 2472429 As a gene expression regulator , overexpression *increased* [p27] , while it decreased cyclin D1 and c-fos expression . Positive_regulation IFI27 RAC1 15213258 1262504 Simvastatin modulates angiotensin II signaling pathway by preventing *mediated* upregulation of [p27] . Positive_regulation IFI27 RALA 11162603 782271 These results suggest that is *involved* in the Ras dependent anchorage independent growth of HT1080 cells by regulating [p27] ( Kip1 ) . Positive_regulation IFI27 RALA 17875936 1818360 Furthermore , farnesylated RalB , but not , *inhibits* the ability of GGTI-2417 to suppress survivin and induce [p27] ( Kip1 ) protein levels . Positive_regulation IFI27 RALB 17875936 1818361 Furthermore , farnesylated , but not RalA , *inhibits* the ability of GGTI-2417 to suppress survivin and induce [p27] ( Kip1 ) protein levels . Positive_regulation IFI27 RET 16953232 1682564 *mediated* regulation of p18 and [p27] , but not of cyclins D1 and D2 , requires functional mitogen activated protein kinase signaling . Positive_regulation IFI27 RHOA 11557735 861444 Wortmannin ( 10 nmol/L ) fully inhibited the decrease in [p27] ( Kip1 ) *induced* by , and a membrane targeted catalytic subunit of phosphatidylinositol-3 kinase ( PI3K [ p110 ( CAAX ) ] ) decreased p27 ( Kip1 ) expression , suggesting that RhoA signals through PI3K . Positive_regulation IFI27 RHOA 9407076 470805 Ras stimulated extracellular signal related kinase 1 and activities coordinate platelet derived growth factor *induced* G1 progression through the independent regulation of cyclin D1 and [p27] . Positive_regulation IFI27 RHOA 9920882 588081 *stimulates* [p27] ( Kip ) degradation through its regulation of cyclin E/CDK2 activity . Positive_regulation IFI27 SF3B1 23594796 2810355 [P27Kip1] ( CDKN1B ) arrests cells in G1 , and ( SF3B1 ) , a subunit of the essential splicing factor 3b (SF3b) subcomplex of the spliceosome , is *required* for proper P27 pre-mRNA splicing . Positive_regulation IFI27 SFN 20642839 2297566 *induced* the expression of p21/CIP1 and [p27/KIP1] , and inhibited the expression of cyclin D1 . Positive_regulation IFI27 SIAH1 21734459 2471769 *regulates* [p27] ( kip1 ) stability and cell migration under metabolic stress . Positive_regulation IFI27 SKP2 10559916 566829 is *required* for ubiquitin mediated degradation of the CDK inhibitor [p27] . Positive_regulation IFI27 SKP2 10790373 689142 Targeted disruption of *results* in accumulation of cyclin E and [p27] ( Kip1 ) , polyploidy and centrosome overduplication . Positive_regulation IFI27 SKP2 11861371 917137 Lack of *results* in [p27] ( Kip1 ) accumulation as well as enlargement and polyploidy of hepatocytes . Positive_regulation IFI27 SKP2 12208864 983930 The S-phase kinase associated protein is *required* for the ubiquitin mediated degradation of the cdk-inhibitor [p27] and is a bona fide proto-oncoprotein . Positive_regulation IFI27 SKP2 14586067 1159422 These results suggest that *regulates* [p27] expression in Merkel cell carcinomas . Positive_regulation IFI27 SKP2 14960249 1208515 Expression of protein may *lead* to decrease [p27] ( kip1 ) level in human prostatic carcinoma , indicating its involvement in the development of human prostatic carcinoma . Positive_regulation IFI27 SKP2 15073847 1232824 The essential role of cyclin kinase subunit 1 (Cks1) in *dependent* [p27] degradation was recently discovered , but its role in human malignancies is unknown . Positive_regulation IFI27 SKP2 15130491 1245413 *mediated* degradation of [p27] regulates progression into mitosis . Positive_regulation IFI27 SKP2 15363035 1293885 Thus , and Jab1 *regulate* [P27] degradation , and might contribute to the development and progression of lung AD through P27 mediated and -unmediated mechanisms . Positive_regulation IFI27 SKP2 15371458 1334530 Evidence for impaired *dependent* degradation of [p27] in terminal differentiation . Positive_regulation IFI27 SKP2 15371458 1334532 These data altogether indicate that the impaired *dependent* [p27] degradation is causally related to the loss of proliferation in cardiomyocytes . Positive_regulation IFI27 SKP2 16024059 1447446 The S-phase kinase associated protein is *required* for the ubiquitin mediated degradation of the cdk-inhibitor [p27] and is a bona fide proto-oncoprotein . Positive_regulation IFI27 SKP2 17372849 1791642 LXR agonists appear to cause G1 cell cycle arrest in cells by reducing expression of and *inducing* the accumulation of [p27] ( Kip ) . Positive_regulation IFI27 SKP2 17407140 1797749 Overexpression of integrin beta1 inhibits proliferation of hepatocellular carcinoma cell SMMC-7721 through preventing *dependent* degradation of [p27] via PI3K pathway . Positive_regulation IFI27 SKP2 19160095 2032396 Taken together , our data indicate that EB1089 inhibitory activity is associated with alteration of cell cycle checkpoints through *dependent* [p27] induction in Hep-G2 cells . Positive_regulation IFI27 SKP2 20924167 2343313 These results suggested that MZR induced [p27] ( kip1 ) accumulation was at least partly *mediated* by , and that Skp2 might be a novel target of MZR inhibiting MC proliferation . Positive_regulation IFI27 SKP2 21245140 2397910 Our data show that is a direct MYC target gene and that MYC mediated SKP2 induction *leads* to reduced [p27] levels . Positive_regulation IFI27 SKP2 22937180 2666956 The ubiquitin-ligase negatively *regulates* [p27] ( Kip1 ) and , during TIS , is translocated to the cytoplasm before its expression is decreased in senescent cells . Positive_regulation IFI27 SKP2 23255047 2827368 *mediated* degradation of [p27] , a cyclin dependent kinase inhibitor , is involved in cell cycle regulation . Positive_regulation IFI27 SKP2 24441545 2922809 Mechanisms in cardiac fibroblast growth : an obligate *role* for and FOXO3a in ERK1/2 MAPK dependent regulation of [p27kip1] . Positive_regulation IFI27 SLC25A16 15252113 1274275 Furthermore , both and BDM suppressed expression of MyoD and myogenin , *induced* [p27] ( kip1 ) but not p21 ( cip1 ) , and inhibited differentiation . Positive_regulation IFI27 SLC9A3R1 22622406 2681567 Additionally , the loss of accentuated ß-catenin activity , increased cyclin E and phosphorylated Rb expression , and *attenuated* [p27] expression compared to control cells . Positive_regulation IFI27 SMAD1 24161934 2864117 TGF-ß2 induced dormancy *required* TGF-ß receptor-I ( TGF-ß-RI ) , TGF-ß-RIII and activation to induce [p27] . Positive_regulation IFI27 SMAD2 25023446 2953164 overexpression *up-regulated* the mRNA expression of P15 by 2.3-fold and that of [P27] by 5.5-fold in the K14-Smad2 mice . Positive_regulation IFI27 SMAD3 17013388 1634077 Thus , [p27] ( Kip1 ) is required during induction of tolerance and *regulates* T cell responses ` downstream ' of p27 ( Kip1 ) . Positive_regulation IFI27 SMAD3 18783370 1969246 This , in turn , prompts enhanced neuronal differentiation via translocation to the nucleus and subsequent [p27] ( kip1 ) *activation* in NPCs . Positive_regulation IFI27 SMARCA4 12244326 992801 *enhances* the IFN-alpha induced expression of 9-27 and [IFI27] but not that of four other target genes tested , showing that the activation of different target genes by STAT2 may involve alternative chromatin modifiers . Positive_regulation IFI27 SNX6 20228253 2293708 We therefore conclude that , in addition to the proteasome dependent pathway , *mediated* endolysosomal degradation of [p27] also contributes to cell cycle progression in mammalian cells . Positive_regulation IFI27 SOCS1 11818334 908168 was initially identified as a co-activator of c-Jun , and it also *induces* degradation of cell cycle inhibitor [p27] and tumor suppressor p53 . Positive_regulation IFI27 SOCS1 12631617 1067797 These findings suggest that *mediated* degradation of [p27] , allowing cell cycle progression , may play a role in the pathogenesis of ALCL . Positive_regulation IFI27 SOCS1 15363035 1293886 Thus , Skp2 and *regulate* [P27] degradation , and might contribute to the development and progression of lung AD through P27 mediated and -unmediated mechanisms . Positive_regulation IFI27 SOCS1 15930262 1414438 In this process , VDUP1 blocked the *mediated* translocation of [p27] ( kip1 ) from the nucleus to the cytoplasm . Positive_regulation IFI27 SOCS1 16951171 1610389 These findings suggest that JAB1 overexpression is involved in the pathogenesis of pancreatic cancer through *mediated* [p27] degradation and that control of JAB1 expression is a novel therapeutic target in patients with pancreatic adenocarcinomas . Positive_regulation IFI27 SOCS1 19349901 2094416 Overexpression of in ECA109 cells *resulted* in decreased [p27] level and this decrease was sensitive to 26S proteasome inhibitors . Positive_regulation IFI27 SOCS1 21935931 2487483 , a co-activator of AP-1 transcription factor and the fifth subunit of the COP9 signalosome , *mediates* degradation of the tumor suppressor p53 and [p27] ( Kip1 ) and functions as a tumor promoter in different types of human cancer . Positive_regulation IFI27 SOCS1 22350412 2576573 negatively *regulates* [p27] and plays a role in the pathogenesis of nasopharyngeal carcinoma . Positive_regulation IFI27 SP1 11231912 789654 Collectively , these results demonstrate that Sp1 is essential for maximum p27 promoter activity in VSMCs and suggest that posttranslational induction of DNA binding activity *contributes* to the induction of [p27] expression and VSMC growth arrest at late time points after balloon angioplasty . Positive_regulation IFI27 SP1 19433067 2101295 Promoter deletion studies with p27 ( Kip1 ) reporter gene constructs showed that this DIM mediated increase in [p27] ( Kip1 ) was *dependent* on the . Positive_regulation IFI27 SPDYA 17671428 1780567 Our studies provide evidence that expression *enhances* CDK2 dependent [p27] degradation during late G1 and throughout S-phase . Positive_regulation IFI27 SRC 17254967 1691044 Here , we present data indicating that the oncogenic kinase *regulates* [p27] stability through phosphorylation of p27 at tyrosine 74 and tyrosine 88 . Positive_regulation IFI27 TAB2 16467204 1561407 These findings indicate that a Cul4A positively regulates proliferation by targeting p27 for degradation and that Cul4A down-regulation during terminal erythroid differentiation *allows* [p27] to accumulate and signal cell cycle exit . Positive_regulation IFI27 TCEAL1 20216467 2319581 Several exercise mediated responses were found to occur independent of condition : 1 ) muscle [ DNA ] increased at 6 h ( +40 % , P < 0.05 ) , 2 ) CDK4 expression increased at 6 h ( +86 % , P < 0.05 ) , 3 ) MYOD expression increased at 6 h ( +98 % , P < 0.05 ) , 4 ) [P27] ( KIP1 ) expression decreased at 2 h ( j35 % , P < 0.05 ) and 6 h ( -59 % , P < 0.001 ) , and 5 ) ( CIP1 ) expression substantially *increased* 2 and 6 h postexercise ( +1.250 % and +4.670 % , respectively , P < 0.001 ) . Positive_regulation IFI27 TFPT 11259850 796041 Conversely , *induced* expression of CDK inhibitors , p21 ( Waf1/Cip1 ) , [p27] ( Kip1 ) , and p57(Kip2) in monkey kidney cells ( CV-1 ) . Positive_regulation IFI27 TGFB1 10613355 575593 *Up-regulation* of [p27] protein expression by either or EB1089 was reduced by anti-TGF-beta1 . Positive_regulation IFI27 TGFB1 10942583 722590 We show here that *induces* the accumulation of a form of [p27] ( Kip1 ) representing a subpopulation of total p27 ( Kip1 ) in growth arrested Mv1Lu epithelial cells . Positive_regulation IFI27 TGFB1 11281653 798975 inhibited cyclin D2 expression and *up-regulated* [p27] ( KIP1 ) levels only when acting as inhibitor of MPA induced proliferation of C4HD cells . Positive_regulation IFI27 TGFB1 15811853 1410625 By contrast , Smad7 overexpression interfered with *mediated* attenuation of cyclin A and B levels , inhibition of cdc2 dephosphorylation and CDK2 inactivation , up-regulation of [p27] , and the maintenance of the retinoblastoma protein ( RB ) in a hypophosphorylated state . Positive_regulation IFI27 TGFB1 15899124 1408715 treatment *induced* [P27] to congregate around nucleus . Positive_regulation IFI27 TGFB1 18418730 2052948 did not *increase* [p27] expression in Tca8113 cells , but p27 expression was increased in Tb cells . Positive_regulation IFI27 TGFB2 10942583 722591 We show here that *induces* the accumulation of a form of [p27] ( Kip1 ) representing a subpopulation of total p27 ( Kip1 ) in growth arrested Mv1Lu epithelial cells . Positive_regulation IFI27 TGFB3 10942583 722592 We show here that *induces* the accumulation of a form of [p27] ( Kip1 ) representing a subpopulation of total p27 ( Kip1 ) in growth arrested Mv1Lu epithelial cells . Positive_regulation IFI27 TLR3 21130742 2372796 Cxcl10 , Mx1 , Ifi44 , [Ifi203] , Iigp2 and Rtp4 were dominantly *regulated* by IPS-1 , Ccl5 by , and Rsad2 , Mx2 and Cmpk2 were regulated by TLR3 and IPS-1 . Positive_regulation IFI27 TM4SF5 22014979 2527001 These observations suggest involvement of JNKs in *mediated* [p27] ( Kip1 ) Ser10 phosphorylation and localization during epithelial-mesenchymal transition . Positive_regulation IFI27 TMED7 10995887 733654 These data indicate that the cytoplasmic localization of [p27KIP1] in the process of differentiation is *due* to upregulation of synthesis and subsequent degradation and suggest a role of p27KIP1 in differentiation of neuroblastoma . Positive_regulation IFI27 TMED7 17237771 1690422 Thus LKB1-AMPK pathway dependent phosphorylation of at Thr 198 *stabilizes* [p27] and permits cells to survive growth factor withdrawal and metabolic stress through autophagy . Positive_regulation IFI27 TMED7 18319192 1886145 Taken together , we hypothesized spinal cord injury stimulated mitogenic signals to *induce* a serine-threonine kinase KIS ( kinase interacting stathmin ) to phosphorylate [p27kip1] on Serine-10 , so that could bind to CRM1 and be exported from nuclei for degradation . Positive_regulation IFI27 TMED7 18701472 1950380 Cytoplasmic localization of in Tsc2-null cells was reversible pharmacologically using inhibitors of the LKB1/AMPK pathway , and localization of [p27] to the cytoplasm could be *induced* directly by activating AMPK physiologically ( glucose deprivation ) or genetically ( constitutively active AMPK ) in Tsc2-proficient cells . Positive_regulation IFI27 TMED7 21818355 2462925 Our results show that expression of ( kip ) was lost in the IRF4 ( +/- ) Myc leukemic cells and reconstitution of IRF4 expression in those cells *induced* [p27] ( kip ) and inhibited their expansion . Positive_regulation IFI27 TNF 21075101 2371462 *regulates* [p27] kip expression and apoptosis in smooth muscle cells of human carotid plaques via forkhead transcription factor O1 . Positive_regulation IFI27 TNFSF12 19887380 2203400 Stimulation of neonatal rat cardiomyocytes with *resulted* in increased DNA synthesis , increased expression of the proliferative markers Cyclin D2 and Ki67 , and downregulation of the cell cycle inhibitor [p27KIP1] . Positive_regulation IFI27 TP53 17143939 1653820 Troglitazone may induce p53 independent apoptosis and *dependent* expression of p21 and [p27] . Positive_regulation IFI27 TP53 21639915 2450952 Thus , the ( mut ) complex *leads* to elevated [p27kip1] expression and promotes cell cycle arrest . Positive_regulation IFI27 TRAF6 16467204 1561405 These findings indicate that a Cul4A positively regulates proliferation by targeting p27 for degradation and that Cul4A down-regulation during terminal erythroid differentiation *allows* [p27] to accumulate and signal cell cycle exit . Positive_regulation IFI27 TXNIP 15930262 1414415 Tumor suppressor *increases* [p27] ( kip1 ) stability by inhibiting JAB1 . Positive_regulation IFI27 UBE2M 21477582 2434015 The induction of UBE2M by Gem was accompanied by a reduction in p27 ( Kip1 ) protein levels , which could be restored by silencing UBE2M expression with siRNA or by treating cells with the proteasome inhibitor MG132 , indicating that *mediates* Gem induced [p27] ( Kip1 ) protein degradation . Positive_regulation IFI27 UBE2V1 16467204 1561406 These findings indicate that a Cul4A positively regulates proliferation by targeting p27 for degradation and that Cul4A down-regulation during terminal erythroid differentiation *allows* [p27] to accumulate and signal cell cycle exit . Positive_regulation IFI27 UBE3A 19591933 2130612 Our result suggests that not only enhances the degradation but also *regulates* the expression of [p27] and its loss of function in Angelman syndrome might cause cell cycle alteration leading to disease pathogenesis . Positive_regulation IFI27 UCN 9108451 424753 also *increased* the expression of the CDK inhibitor [p27] protein after 24 h exposure at 260 and 520 nM . Positive_regulation IFI27 XPO1 18319192 1886143 Taken together , we hypothesized spinal cord injury stimulated mitogenic signals to *induce* a serine-threonine kinase KIS ( kinase interacting stathmin ) to phosphorylate [p27kip1] on Serine-10 , so that p27kip1 could bind to and be exported from nuclei for degradation . Positive_regulation IFI27 XPO1 23494640 2823012 There is increasing evidence that *mediated* [P27] ( Kip1 ) , which is a potent inhibitor of G1 cyclin dependent kinases complexes , nuclear export dependent or -independent Jab1/CSN5 , and cytoplasmic degradation in cells . Positive_regulation IFI27 YY1 22440256 2588391 plays an essential role in breast cancer and negatively *regulates* [p27] . Positive_regulation IFI27 ZNF23 17137575 1678027 Ectopic expression of *led* to enhancement of [p27] ( kip-1 ) expression , growth inhibition and cell cycle arrest in G ( 1 ) phase . Positive_regulation IFI44 ADRB2 10196213 604409 However , endocytosis does not appear to be required for alpha2-adrenergic , epidermal growth factor , lysophosphatidic acid , or *mediated* [p42/p44] MAP kinase activation in COS-1 cells . Positive_regulation IFI44 CD14 7521366 269322 *dependent* activation of protein kinase C and mitogen activated protein kinases ( p42 and [p44] ) in human monocytes treated with bacterial lipopolysaccharide . Positive_regulation IFI44 CTGF 16408113 1513527 P-PI3-K blockade downregulated the *stimulated* expression of P-PI3-K , P-Akt , and NF-kappaB but not [P-p42/44] MAPK , and partially decreased the release of the above chemokines . Positive_regulation IFI44 CTGF 16408113 1513536 LXA ( 4 ) dose-dependently inhibited the *stimulated* mRNA expression and protein release of the above chemokines , and the expression of [P-p42/44MAPK] , P-PI3-K , P-Akt , and NF-kappaB . Positive_regulation IFI44 EFNB1 15502157 1347552 Further downstream of the signaling pathway , stimulation *led* to increased LAT ( linker for activation of T-cells ) phosphorylation and [p44/42] and p38 MAPK activation . Positive_regulation IFI44 EPHB2 21518868 2428889 EGF activates NF-?B and stimulates phosphorylation of FER , EGF receptor (EGFR) , and ERK [p42/p44] , and decreased expression of FER or inhibition of phosphorylation *inhibits* the EGF induced activation of NF-?B . Positive_regulation IFI44 F2R 11841573 912180 Activation of the microglial *induces* a rapid cytosolic free [ Ca2+ ] i increase and transient activation of both p38 and [p44/42] mitogen activated protein kinases . Positive_regulation IFI44 F2R 19360302 2058254 We found that stimulation of HCC cells with thrombin , the activating peptide , TFLLRN-NH2 , and the PAR4-selective activating peptide , AYPGKF-NH2 , increased cell invasion across a Matrigel coated membrane barrier and *stimulated* activation of [p42/p44] MAPKinase phosphorylation . Positive_regulation IFI44 F2R 21252088 2402878 In the present study , we show that FVIIa , upon binding to EPCR on endothelial cells , activates endogenous protease activated receptor-1 (PAR1) and induces mediated [p44/42] mitogen activated protein kinase (MAPK) *activation* . Positive_regulation IFI44 FAS 16024776 1435370 In contrast , *mediated* activation of JNK , p38 , and [p42/44] occurred essentially independent from IFN-gamma sensitization , indicating that the apoptosis- and NF-kappaB related FasL-IFN-gamma cross talk was not due to a simple global enhancement of Fas signaling . Positive_regulation IFI44 IL1B 11455208 837910 TNF-alpha and *activated* [p44/42] and p38 mitogen activated protein kinases ( MAPKs ) in HUVECs ; Positive_regulation IFI44 IL1B 11777983 899891 Furthermore , IL-17 , , and TNF-alpha *induced* a rapid activation of extracellular signal related kinase [p42/44] and p38 MAPKs , and specific MAPK inhibitors ( SB203580 , PD98059 , and U0216 ) significantly reduced IL-17- , IL-1beta- , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Positive_regulation IFI44 IL1B 12356282 993769 *induced* [p44/42] mitogen activated protein kinase (MAPK) activation was inhibited by the MAPK/extracellular signal regulated protein kinase ( MEK ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation IFI44 IL1B 12760902 1119667 and TGF-beta1 *induced* an activation of ERK [p42/44] and p38 MAP kinases , and the MAP kinase inhibitors ( SB-202190 , PD-98059 , and U-0216 ) significantly reduced the IL-1beta- and TGF-beta1 induced IL-11 secretion . Positive_regulation IFI44 IL1B 15067222 1231907 This hypothesis was further supported by the transient activation of [p42/p44] and p38 MAPKs *induced* by . Positive_regulation IFI44 IL1B 16141635 1454861 DHA stimulated both rapid and prolonged activation of [p44/42] , but not p38 , mitogen activated protein kinase (MAPK) *induced* by and PMA . Positive_regulation IFI44 IL1B 16521184 1531270 *activates* [p44/42] and p38 mitogen activated protein kinases via different pathways in cat esophageal smooth muscle cells . Positive_regulation IFI44 IL1B 16521184 1531272 Phosphokinase C ( PKC ) was found to play a mediating role in the *induced* [p44/42] MAP kinase activity . Positive_regulation IFI44 IL1B 16521184 1531274 Based on these results , *induced* [p44/42] MAP kinase activation is mediated by the Gi protein , tyrosine kinase , phospholipase C (PLC) and PKC . Positive_regulation IFI44 IL1B 19446813 2141901 Furthermore , digitoxin prevented the *induced* activation of [p44/42-MAPK] and NF-kappaB without affecting activation of JNK and p38-MAPK . Positive_regulation IFI44 LBP 11134043 794920 Here we show that secretion of tumor necrosis factor-alpha induced by Treponema culture supernatants and extracted LTA was paralleled by an *dependent* phosphorylation of mitogen activated protein kinases ( MAPKs ) p42 and [p44] , and p38 , as well as the stress activated protein kinases c-Jun N-terminal kinases 1 and 2 . Positive_regulation IFI44 MAP2K6 11462762 839157 These injury conditions led to a rapid phosphorylation of [p44/42] that was *blocked* by inhibitors . Positive_regulation IFI44 MAP2K6 11479233 842199 Inhibitors of ( U0126 ) and PI3K ( LY294002 ) *blocked* [p42/p44] ( erk ) and Akt , respectively , and partially blocked HGF induced production of IL-8 and VEGF , whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A . Positive_regulation IFI44 MAP2K6 12356282 993775 IL-1beta induced [p44/42] mitogen activated protein kinase (MAPK) activation was *inhibited* by the MAPK/extracellular signal regulated protein kinase ( ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation IFI44 MAP2K6 9626658 511838 These results indicate that *mediates* the IGF-I/insulin induced p42/ [p44] MAPK activation . Positive_regulation IFI44 PLAU 15031204 1257162 In HeLa cells the dominant negative form of JNK interferes with the [p42/p44] MAPK *activation* of the . Positive_regulation IFI44 TNF 11043572 742367 These activation kinetics suggest a mechanism of p42/44 action more complicated than a direct phosphorylation of IRS-1 triggered by the early spike of *induced* [p42/44] activity . Positive_regulation IFI44 TNF 11435466 832521 However , the cytotoxic responses to daunorubicin and exogenous ceramide remain unaltered , as do the *induced* [p42/p44] MAPK activation and CD54 expression . Positive_regulation IFI44 TNF 11438547 843387 *activated* p38 MAPK and [p44/p42] MAPK in wild-type but not in p60 ( -/- ) , p80 ( -/- ) , or p60 ( -/- ) p80 ( -/- ) macrophages . Positive_regulation IFI44 TNF 11455208 837909 and IL-1beta *activated* [p44/42] and p38 mitogen activated protein kinases ( MAPKs ) in HUVECs ; Positive_regulation IFI44 TNF 11495721 846378 Furthermore , overexpression of dominant negative mutants , H-Ras-15A and Raf-N4 , significantly suppressed [p42/p44] mitogen activated protein kinase (MAPK) activation *induced* by and PDGF-BB and attenuated the effect of TNF-alpha on BK-induced IP response , indicating that Ras and Raf may be required for activation of these kinases . Positive_regulation IFI44 TNF 11777983 899888 Furthermore , IL-17 , IL-1beta , and *induced* a rapid activation of extracellular signal related kinase [p42/44] and p38 MAPKs , and specific MAPK inhibitors ( SB203580 , PD98059 , and U0216 ) significantly reduced IL-17- , IL-1beta- , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Positive_regulation IFI44 TNF 11930247 927412 The [p44/42] MAPK activity was significantly *enhanced* by and the TNF-alpha effect was opposed by rhIL-10 . Positive_regulation IFI44 TNF 12160518 971794 *activated* [p44/42] and p38 MAP kinases , which was inhibited by the specific inhibitors of these kinases , PD98059 or SB202190 , respectively . Positive_regulation IFI44 TNF 14751545 1205478 This hypothesis was further supported by that *induced* a transient activation of [p42/p44] and p38 MAPKs in a time-and concentration dependent manner . Positive_regulation IFI44 TNF 15240695 1270311 Jurkat cells that did not express Syk ( JCaM1 , JCaM1/lck ) showed lack of *induced* Syk , JNK , p38 MAPK , and [p44/p42] MAPK activation , as well as TNF induced IkappaBalpha phosphorylation , IkappaBalpha degradation , and NF-kappaB activation . Positive_regulation IFI44 TNF 15365619 1334202 Rosiglitazone ameliorates insulin resistance in brown adipocytes of Wistar rats by impairing *induction* of p38 and [p42/p44] mitogen activated protein kinases . Positive_regulation IFI44 TNF 15452110 1341984 In contrast , *induced* [p42/p44] MAPK activation and CD54 expression remained unaltered . Positive_regulation IFI44 TNF 16682409 1584049 Further , the deletion of NQO1 abolished *induced* c-Jun N-terminal kinase , Akt , p38 , and [p44/p42] mitogen activated protein kinase activation . Positive_regulation IFI44 TNF 17161959 1694530 Upon examination of the signaling components , we found that was a potent *activator* of p38 , [p44/42] , p54/46 MAPK , and IkappaBalpha ( IkappaBalpha ) . Positive_regulation IFI44 TNF 17942934 1814206 Deletion of NQO2 also abolished induced c-Jun NH2-terminal kinase , Akt , p38 , and [p44/p42] mitogen activated protein kinase *activation* . Positive_regulation IFI44 TNF 18258304 1884774 *induces* [p42/p44] , p54 and p38 MAPK kinase ; Positive_regulation IFI44 TNF 18258304 1884789 However , over-expression of a dominant negative form of Rac strongly inhibited *induced* [p42/44] MAPK kinase activation , but had little effect upon JNK and no effect upon p38 MAPK activity . Positive_regulation IFI44 TNF 19441104 2101425 D10 supplementation did not suppress activation of hepatocyte growth factor (HGF) , induction of transforming growth factor alpha ( TGF-alpha ) expression , or alpha-interleukin-6 cytokine signaling , [p42/44] extracellular signal regulated kinase ( ERK ) *activation* , immediate early gene expression , or expression of CCAAT/enhancer binding protein beta ( C/EBPbeta ) , but did augment expression of the mito-inhibitory factors C/EBPalpha , p21 ( Waf1/Cip1 ) , and p27 ( Kip1 ) . Positive_regulation IFI44 TNF 20372827 2238933 VIP markedly up-regulated the *induced* [p44/p42] MAP kinase phosphorylation . Positive_regulation IFI44 TNF 24441870 2922922 We showed that markedly *stimulated* Jak2 , PDGFR , Akt , and [p42/p44] MAPK phosphorylation , which were attenuated by their respective inhibitors . Positive_regulation IFI44 TNF 24441870 2922944 In addition , *induced* [p42/p44] MAPK phosphorylation was reduced by AG1296 or LY294002 . Positive_regulation IFI44 TNF 24441870 2922977 On the other hand , could *induce* Akt and [p42/p44] MAPK translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation IFI44 TNF 7726846 302073 Since we recently found that stimulation of neutrophils does not *increase* the tyrosine phosphorylation or activation of the p42erk2 and [p44erk1] mitogen activated protein kinases ( MAPKs ) , the present studies demonstrate the involvement of a MAPK independent pathway in the phosphorylation and activation of cPLA2 . Positive_regulation IFI44 TNF 8626494 360269 Inhibition of *induced* [p42/p44] mitogen activated protein kinase activation by sodium salicylate . Positive_regulation IFI44 TNF 8626494 360311 We now show that neither phorbol ester-sensitive protein kinase C nor Gialpha link TNF to p42/p44 MAPK activation , because pretreatment of FS-4 cells with phorbol ester to down-regulate protein kinase C or pretreatment with pertussis toxin to block Gialpha does not inhibit [p42/p44] MAPK *activation* by . Positive_regulation IFI44 TNF 8626494 360326 To further analyze MAPK activation in FS-4 cells , we compared [p42/p44] MAPK *activation* by and epidermal growth factor (EGF) . Positive_regulation IFI44 TNF 8626494 360356 Elucidation of the mechanism whereby sodium salicylate blocks *induced* [p42/p44] MAPK activation may help to clarify TNF activated signaling pathways . Positive_regulation IFI44 TNF 9096313 422377 In a previous study , we demonstrated that sodium salicylate ( NaSal ) selectively inhibits induced *activation* of the p42 and [p44] mitogen activated protein kinases ( MAPKs ) ( known as extracellular signal regulated kinases ) . Positive_regulation IFI44 TNF 9885438 558289 On the other hand , selectively induced tyrosine phosphorylation of p42 , and PMA selectively *induced* that of [p44] and p42 . Positive_regulation IFI44 TNFSF10 19895579 2176165 Preceding cell death , *activated* nuclear factor kappaB , c-Jun N-terminal kinase , p38 and [p42/44] . Positive_regulation IFIT3 F2R 8780738 380220 Both thrombin and *activated* p72syk and [p60c-src] with similar magnitudes . Positive_regulation IFIT3 IL1B 14622206 1168657 The hypothesis that the synthesis of SP in and secretion from the primary sensory ganglia are regulated by the activation of [p60c-src] kinase *induced* by was tested . Positive_regulation IFIT3 IL1B 14622206 1168661 SB 203580 [ a p38 mitogen activated protein kinase ( p38 MAPK ) inhibitor ] and PD 98059 ( a p44/42 MAPK kinase inhibitor ) were ineffective in modulating *induced* SP synthesis and secretion , and [p60c-src] kinase activity in DRG neurons . Positive_regulation IFIT3 IL1B 14622206 1168662 In view of the role of SP as an immunomodulator , these studies provide a new insight into neural-immune intercommunication in pain regulation in the sensory ganglia through the *induced* [p60c-src] activation . Positive_regulation IFIT3 TNF 12055072 951598 In adherent neutrophils , *triggers* association of both protein kinase C (PKC)-delta and phosphatidylinositol (PI) 3-kinase with the [p60TNFR] . Positive_regulation IFIT3 TNF 8182064 256461 By using receptor blocking antibodies we found that both p60 and p80 forms of TNF receptors were functional for NBT reducing activity , but dependent NF-kappa B activation *required* only the [p60] receptor . Positive_regulation IFITM1 EPHB2 20847954 2319262 CD147 induced expression of [IFITM1] was *blocked* by inhibitors of , PI3K , or NF-?B , but not by inhibitors of p38 , JNK , or PKC . Positive_regulation IFN1@ TLR7 19047436 2001649 Collectively , the data demonstrate that TMPD stimulated [IFN-I] production *requires* signaling and is independent of autoantibody mediated uptake of ribonucleoproteins by FcgammaRs . Positive_regulation IFN1@ TLR7 22227568 2544658 TLR2 also inhibited *induction* of [IFN-I] by , another MyD88 dependent IFN-I inducing receptor , but did not inhibit IFN-I induction by TLR3 or TLR4 ( both Toll/IL-1R domain containing adapter inducing IFN-ß dependent , MyD88 independent ) . Positive_regulation IFN1@ TLR7 22227568 2544661 Because IRAK1 is required for *induced* [IFN-I] production , we propose that TLR2 signaling induces rapid depletion of IRAK1 , which impairs IFN-I induction by TLR7/9 . Positive_regulation IFN1@ TLR7 24042114 2866867 is also *required* for induction of [IFN-I] by other species and strains of Plasmodium , including an etiological agent of human disease , P. falciparum , suggesting that malaria parasites harbor a common pathogen associated molecular pattern ( PAMP ) recognized by TLR7 . Positive_regulation IFN1@ TLR7 24814238 2939970 We have identified a clinically correlated significant decrease of the *induced* [IFN-alfa (IFNa)] secretion by pDCs from MS patients . Positive_regulation IFN1@ TNF 14991436 1215462 The low virus titres within brains of resistant mice coincided with a very mild inflammation , low counts of infiltrating inflammatory cells , and lower [IFN I/II] and gene *induction* than in susceptible mice . Positive_regulation IFNA1 TLR7 12045249 950100 [Interferon-alpha] and interleukin-12 are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IFNA1 TLR7 15297396 1283350 Via interaction with on immune cells , imiquimod *induces* local production of cytokines , such as [interferon (IFN)-alpha] . Positive_regulation IFNA1 TLR7 15767370 1384064 Interleukin-1 receptor associated kinase-1 plays an essential role for and TLR9 mediated [interferon-{alpha] } *induction* . Positive_regulation IFNA1 TLR7 18806803 1969807 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Positive_regulation IFNA1 TLR7 19597505 2117973 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Positive_regulation IFNA1 TLR7 20684157 2299107 This drug elicits its immunological response by binding to on dendritic cells *inducing* the production of [interferon alpha (IFN-alpha)] and other inflammatory cytokines . Positive_regulation IFNA1 TLR7 24855048 2940670 By blocking the and 9 in plasmacytoid dendritic cells , HCQ *inhibits* [interferon-alpha] production which plays a crucial role in SLE pathogenesis . Positive_regulation IFNA1 TNF 1696166 137194 Both and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , [interferon (IFN)-alpha] , or IFN-gamma . Positive_regulation IFNA1 TNF 18050196 1833223 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Positive_regulation IFNA1 TNF 20304804 2266016 Moreover , we have evidenced that ( 1 ) nanometric particles *induce* production of [interferon-alpha] , whereas ( 2 ) micrometric particles mainly induce production of in human immune cells . Positive_regulation IFNA1 TNFSF10 17617740 1815964 [Interferon-alpha] *induces* expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation IFNA1 TNFSF10 20663526 2305202 [Interferon-alpha] did not *induce* changes in or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation IFNA10 TLR7 12045249 950101 [Interferon-alpha] and interleukin-12 are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IFNA10 TLR7 15297396 1283351 Via interaction with on immune cells , imiquimod *induces* local production of cytokines , such as [interferon (IFN)-alpha] . Positive_regulation IFNA10 TLR7 15767370 1384066 Interleukin-1 receptor associated kinase-1 plays an essential role for and TLR9 mediated [interferon-{alpha] } *induction* . Positive_regulation IFNA10 TLR7 18806803 1969808 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Positive_regulation IFNA10 TLR7 19597505 2117974 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Positive_regulation IFNA10 TLR7 20684157 2299108 This drug elicits its immunological response by binding to on dendritic cells *inducing* the production of [interferon alpha (IFN-alpha)] and other inflammatory cytokines . Positive_regulation IFNA10 TLR7 24855048 2940671 By blocking the and 9 in plasmacytoid dendritic cells , HCQ *inhibits* [interferon-alpha] production which plays a crucial role in SLE pathogenesis . Positive_regulation IFNA10 TNF 1696166 137195 Both and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , [interferon (IFN)-alpha] , or IFN-gamma . Positive_regulation IFNA10 TNF 18050196 1833224 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Positive_regulation IFNA10 TNF 20304804 2266017 Moreover , we have evidenced that ( 1 ) nanometric particles *induce* production of [interferon-alpha] , whereas ( 2 ) micrometric particles mainly induce production of in human immune cells . Positive_regulation IFNA10 TNFSF10 17617740 1815965 [Interferon-alpha] *induces* expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation IFNA10 TNFSF10 20663526 2305203 [Interferon-alpha] did not *induce* changes in or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation IFNA13 TLR7 12045249 950102 [Interferon-alpha] and interleukin-12 are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IFNA13 TLR7 15297396 1283352 Via interaction with on immune cells , imiquimod *induces* local production of cytokines , such as [interferon (IFN)-alpha] . Positive_regulation IFNA13 TLR7 15767370 1384068 Interleukin-1 receptor associated kinase-1 plays an essential role for and TLR9 mediated [interferon-{alpha] } *induction* . Positive_regulation IFNA13 TLR7 18806803 1969809 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Positive_regulation IFNA13 TLR7 19597505 2117975 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Positive_regulation IFNA13 TLR7 20684157 2299109 This drug elicits its immunological response by binding to on dendritic cells *inducing* the production of [interferon alpha (IFN-alpha)] and other inflammatory cytokines . Positive_regulation IFNA13 TLR7 24855048 2940672 By blocking the and 9 in plasmacytoid dendritic cells , HCQ *inhibits* [interferon-alpha] production which plays a crucial role in SLE pathogenesis . Positive_regulation IFNA13 TNF 1696166 137196 Both and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , [interferon (IFN)-alpha] , or IFN-gamma . Positive_regulation IFNA13 TNF 18050196 1833225 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Positive_regulation IFNA13 TNF 20304804 2266018 Moreover , we have evidenced that ( 1 ) nanometric particles *induce* production of [interferon-alpha] , whereas ( 2 ) micrometric particles mainly induce production of in human immune cells . Positive_regulation IFNA13 TNFSF10 17617740 1815966 [Interferon-alpha] *induces* expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation IFNA13 TNFSF10 20663526 2305204 [Interferon-alpha] did not *induce* changes in or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation IFNA14 TLR7 12045249 950103 [Interferon-alpha] and interleukin-12 are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IFNA14 TLR7 15297396 1283353 Via interaction with on immune cells , imiquimod *induces* local production of cytokines , such as [interferon (IFN)-alpha] . Positive_regulation IFNA14 TLR7 15767370 1384070 Interleukin-1 receptor associated kinase-1 plays an essential role for and TLR9 mediated [interferon-{alpha] } *induction* . Positive_regulation IFNA14 TLR7 18806803 1969810 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Positive_regulation IFNA14 TLR7 19597505 2117976 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Positive_regulation IFNA14 TLR7 20684157 2299110 This drug elicits its immunological response by binding to on dendritic cells *inducing* the production of [interferon alpha (IFN-alpha)] and other inflammatory cytokines . Positive_regulation IFNA14 TLR7 24855048 2940673 By blocking the and 9 in plasmacytoid dendritic cells , HCQ *inhibits* [interferon-alpha] production which plays a crucial role in SLE pathogenesis . Positive_regulation IFNA14 TNF 1696166 137197 Both and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , [interferon (IFN)-alpha] , or IFN-gamma . Positive_regulation IFNA14 TNF 18050196 1833226 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Positive_regulation IFNA14 TNF 20304804 2266019 Moreover , we have evidenced that ( 1 ) nanometric particles *induce* production of [interferon-alpha] , whereas ( 2 ) micrometric particles mainly induce production of in human immune cells . Positive_regulation IFNA14 TNFSF10 17617740 1815967 [Interferon-alpha] *induces* expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation IFNA14 TNFSF10 20663526 2305205 [Interferon-alpha] did not *induce* changes in or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation IFNA16 TLR7 12045249 950104 [Interferon-alpha] and interleukin-12 are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IFNA16 TLR7 15297396 1283354 Via interaction with on immune cells , imiquimod *induces* local production of cytokines , such as [interferon (IFN)-alpha] . Positive_regulation IFNA16 TLR7 15767370 1384072 Interleukin-1 receptor associated kinase-1 plays an essential role for and TLR9 mediated [interferon-{alpha] } *induction* . Positive_regulation IFNA16 TLR7 18806803 1969811 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Positive_regulation IFNA16 TLR7 19597505 2117977 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Positive_regulation IFNA16 TLR7 20684157 2299111 This drug elicits its immunological response by binding to on dendritic cells *inducing* the production of [interferon alpha (IFN-alpha)] and other inflammatory cytokines . Positive_regulation IFNA16 TLR7 24855048 2940674 By blocking the and 9 in plasmacytoid dendritic cells , HCQ *inhibits* [interferon-alpha] production which plays a crucial role in SLE pathogenesis . Positive_regulation IFNA16 TNF 1696166 137198 Both and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , [interferon (IFN)-alpha] , or IFN-gamma . Positive_regulation IFNA16 TNF 18050196 1833227 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Positive_regulation IFNA16 TNF 20304804 2266020 Moreover , we have evidenced that ( 1 ) nanometric particles *induce* production of [interferon-alpha] , whereas ( 2 ) micrometric particles mainly induce production of in human immune cells . Positive_regulation IFNA16 TNFSF10 17617740 1815968 [Interferon-alpha] *induces* expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation IFNA16 TNFSF10 20663526 2305206 [Interferon-alpha] did not *induce* changes in or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation IFNA17 TLR7 12045249 950105 [Interferon-alpha] and interleukin-12 are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IFNA17 TLR7 15297396 1283355 Via interaction with on immune cells , imiquimod *induces* local production of cytokines , such as [interferon (IFN)-alpha] . Positive_regulation IFNA17 TLR7 15767370 1384074 Interleukin-1 receptor associated kinase-1 plays an essential role for and TLR9 mediated [interferon-{alpha] } *induction* . Positive_regulation IFNA17 TLR7 18806803 1969812 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Positive_regulation IFNA17 TLR7 19597505 2117978 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Positive_regulation IFNA17 TLR7 20684157 2299112 This drug elicits its immunological response by binding to on dendritic cells *inducing* the production of [interferon alpha (IFN-alpha)] and other inflammatory cytokines . Positive_regulation IFNA17 TLR7 24855048 2940675 By blocking the and 9 in plasmacytoid dendritic cells , HCQ *inhibits* [interferon-alpha] production which plays a crucial role in SLE pathogenesis . Positive_regulation IFNA17 TNF 1696166 137199 Both and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , [interferon (IFN)-alpha] , or IFN-gamma . Positive_regulation IFNA17 TNF 18050196 1833228 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Positive_regulation IFNA17 TNF 20304804 2266021 Moreover , we have evidenced that ( 1 ) nanometric particles *induce* production of [interferon-alpha] , whereas ( 2 ) micrometric particles mainly induce production of in human immune cells . Positive_regulation IFNA17 TNFSF10 17617740 1815969 [Interferon-alpha] *induces* expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation IFNA17 TNFSF10 20663526 2305207 [Interferon-alpha] did not *induce* changes in or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation IFNA2 TLR7 12045249 950106 [Interferon-alpha] and interleukin-12 are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IFNA2 TLR7 15297396 1283356 Via interaction with on immune cells , imiquimod *induces* local production of cytokines , such as [interferon (IFN)-alpha] . Positive_regulation IFNA2 TLR7 15767370 1384076 Interleukin-1 receptor associated kinase-1 plays an essential role for and TLR9 mediated [interferon-{alpha] } *induction* . Positive_regulation IFNA2 TLR7 18806803 1969813 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Positive_regulation IFNA2 TLR7 19597505 2117979 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Positive_regulation IFNA2 TLR7 20684157 2299113 This drug elicits its immunological response by binding to on dendritic cells *inducing* the production of [interferon alpha (IFN-alpha)] and other inflammatory cytokines . Positive_regulation IFNA2 TLR7 24855048 2940676 By blocking the and 9 in plasmacytoid dendritic cells , HCQ *inhibits* [interferon-alpha] production which plays a crucial role in SLE pathogenesis . Positive_regulation IFNA2 TNF 1696166 137200 Both and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , [interferon (IFN)-alpha] , or IFN-gamma . Positive_regulation IFNA2 TNF 18050196 1833229 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Positive_regulation IFNA2 TNF 20304804 2266022 Moreover , we have evidenced that ( 1 ) nanometric particles *induce* production of [interferon-alpha] , whereas ( 2 ) micrometric particles mainly induce production of in human immune cells . Positive_regulation IFNA2 TNFSF10 17617740 1815970 [Interferon-alpha] *induces* expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation IFNA2 TNFSF10 20663526 2305208 [Interferon-alpha] did not *induce* changes in or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation IFNA21 TLR7 12045249 950107 [Interferon-alpha] and interleukin-12 are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IFNA21 TLR7 15297396 1283357 Via interaction with on immune cells , imiquimod *induces* local production of cytokines , such as [interferon (IFN)-alpha] . Positive_regulation IFNA21 TLR7 15767370 1384078 Interleukin-1 receptor associated kinase-1 plays an essential role for and TLR9 mediated [interferon-{alpha] } *induction* . Positive_regulation IFNA21 TLR7 18806803 1969814 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Positive_regulation IFNA21 TLR7 19597505 2117980 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Positive_regulation IFNA21 TLR7 20684157 2299114 This drug elicits its immunological response by binding to on dendritic cells *inducing* the production of [interferon alpha (IFN-alpha)] and other inflammatory cytokines . Positive_regulation IFNA21 TLR7 24855048 2940677 By blocking the and 9 in plasmacytoid dendritic cells , HCQ *inhibits* [interferon-alpha] production which plays a crucial role in SLE pathogenesis . Positive_regulation IFNA21 TNF 1696166 137201 Both and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , [interferon (IFN)-alpha] , or IFN-gamma . Positive_regulation IFNA21 TNF 18050196 1833230 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Positive_regulation IFNA21 TNF 20304804 2266023 Moreover , we have evidenced that ( 1 ) nanometric particles *induce* production of [interferon-alpha] , whereas ( 2 ) micrometric particles mainly induce production of in human immune cells . Positive_regulation IFNA21 TNFSF10 17617740 1815971 [Interferon-alpha] *induces* expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation IFNA21 TNFSF10 20663526 2305209 [Interferon-alpha] did not *induce* changes in or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation IFNA4 TLR7 12045249 950108 [Interferon-alpha] and interleukin-12 are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IFNA4 TLR7 15297396 1283358 Via interaction with on immune cells , imiquimod *induces* local production of cytokines , such as [interferon (IFN)-alpha] . Positive_regulation IFNA4 TLR7 15767370 1384080 Interleukin-1 receptor associated kinase-1 plays an essential role for and TLR9 mediated [interferon-{alpha] } *induction* . Positive_regulation IFNA4 TLR7 18806803 1969815 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Positive_regulation IFNA4 TLR7 19597505 2117981 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Positive_regulation IFNA4 TLR7 20684157 2299115 This drug elicits its immunological response by binding to on dendritic cells *inducing* the production of [interferon alpha (IFN-alpha)] and other inflammatory cytokines . Positive_regulation IFNA4 TLR7 24855048 2940678 By blocking the and 9 in plasmacytoid dendritic cells , HCQ *inhibits* [interferon-alpha] production which plays a crucial role in SLE pathogenesis . Positive_regulation IFNA4 TNF 1696166 137202 Both and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , [interferon (IFN)-alpha] , or IFN-gamma . Positive_regulation IFNA4 TNF 18050196 1833231 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Positive_regulation IFNA4 TNF 20304804 2266024 Moreover , we have evidenced that ( 1 ) nanometric particles *induce* production of [interferon-alpha] , whereas ( 2 ) micrometric particles mainly induce production of in human immune cells . Positive_regulation IFNA4 TNFSF10 17617740 1815972 [Interferon-alpha] *induces* expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation IFNA4 TNFSF10 20663526 2305210 [Interferon-alpha] did not *induce* changes in or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation IFNA5 TLR7 12045249 950109 [Interferon-alpha] and interleukin-12 are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IFNA5 TLR7 15297396 1283359 Via interaction with on immune cells , imiquimod *induces* local production of cytokines , such as [interferon (IFN)-alpha] . Positive_regulation IFNA5 TLR7 15767370 1384082 Interleukin-1 receptor associated kinase-1 plays an essential role for and TLR9 mediated [interferon-{alpha] } *induction* . Positive_regulation IFNA5 TLR7 18806803 1969816 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Positive_regulation IFNA5 TLR7 19597505 2117982 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Positive_regulation IFNA5 TLR7 20684157 2299116 This drug elicits its immunological response by binding to on dendritic cells *inducing* the production of [interferon alpha (IFN-alpha)] and other inflammatory cytokines . Positive_regulation IFNA5 TLR7 24855048 2940679 By blocking the and 9 in plasmacytoid dendritic cells , HCQ *inhibits* [interferon-alpha] production which plays a crucial role in SLE pathogenesis . Positive_regulation IFNA5 TNF 1696166 137203 Both and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , [interferon (IFN)-alpha] , or IFN-gamma . Positive_regulation IFNA5 TNF 18050196 1833232 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Positive_regulation IFNA5 TNF 20304804 2266025 Moreover , we have evidenced that ( 1 ) nanometric particles *induce* production of [interferon-alpha] , whereas ( 2 ) micrometric particles mainly induce production of in human immune cells . Positive_regulation IFNA5 TNFSF10 17617740 1815973 [Interferon-alpha] *induces* expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation IFNA5 TNFSF10 20663526 2305211 [Interferon-alpha] did not *induce* changes in or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation IFNA6 TLR7 12045249 950110 [Interferon-alpha] and interleukin-12 are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IFNA6 TLR7 15297396 1283360 Via interaction with on immune cells , imiquimod *induces* local production of cytokines , such as [interferon (IFN)-alpha] . Positive_regulation IFNA6 TLR7 15767370 1384084 Interleukin-1 receptor associated kinase-1 plays an essential role for and TLR9 mediated [interferon-{alpha] } *induction* . Positive_regulation IFNA6 TLR7 18806803 1969817 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Positive_regulation IFNA6 TLR7 19597505 2117983 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Positive_regulation IFNA6 TLR7 20684157 2299117 This drug elicits its immunological response by binding to on dendritic cells *inducing* the production of [interferon alpha (IFN-alpha)] and other inflammatory cytokines . Positive_regulation IFNA6 TLR7 24855048 2940680 By blocking the and 9 in plasmacytoid dendritic cells , HCQ *inhibits* [interferon-alpha] production which plays a crucial role in SLE pathogenesis . Positive_regulation IFNA6 TNF 1696166 137204 Both and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , [interferon (IFN)-alpha] , or IFN-gamma . Positive_regulation IFNA6 TNF 18050196 1833233 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Positive_regulation IFNA6 TNF 20304804 2266026 Moreover , we have evidenced that ( 1 ) nanometric particles *induce* production of [interferon-alpha] , whereas ( 2 ) micrometric particles mainly induce production of in human immune cells . Positive_regulation IFNA6 TNFSF10 17617740 1815974 [Interferon-alpha] *induces* expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation IFNA6 TNFSF10 20663526 2305212 [Interferon-alpha] did not *induce* changes in or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation IFNA7 TLR7 12045249 950111 [Interferon-alpha] and interleukin-12 are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IFNA7 TLR7 15297396 1283361 Via interaction with on immune cells , imiquimod *induces* local production of cytokines , such as [interferon (IFN)-alpha] . Positive_regulation IFNA7 TLR7 15767370 1384086 Interleukin-1 receptor associated kinase-1 plays an essential role for and TLR9 mediated [interferon-{alpha] } *induction* . Positive_regulation IFNA7 TLR7 18806803 1969818 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Positive_regulation IFNA7 TLR7 19597505 2117984 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Positive_regulation IFNA7 TLR7 20684157 2299118 This drug elicits its immunological response by binding to on dendritic cells *inducing* the production of [interferon alpha (IFN-alpha)] and other inflammatory cytokines . Positive_regulation IFNA7 TLR7 24855048 2940681 By blocking the and 9 in plasmacytoid dendritic cells , HCQ *inhibits* [interferon-alpha] production which plays a crucial role in SLE pathogenesis . Positive_regulation IFNA7 TNF 1696166 137205 Both and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , [interferon (IFN)-alpha] , or IFN-gamma . Positive_regulation IFNA7 TNF 18050196 1833234 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Positive_regulation IFNA7 TNF 20304804 2266027 Moreover , we have evidenced that ( 1 ) nanometric particles *induce* production of [interferon-alpha] , whereas ( 2 ) micrometric particles mainly induce production of in human immune cells . Positive_regulation IFNA7 TNFSF10 17617740 1815975 [Interferon-alpha] *induces* expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation IFNA7 TNFSF10 20663526 2305213 [Interferon-alpha] did not *induce* changes in or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation IFNA8 TLR7 12045249 950112 [Interferon-alpha] and interleukin-12 are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IFNA8 TLR7 15297396 1283362 Via interaction with on immune cells , imiquimod *induces* local production of cytokines , such as [interferon (IFN)-alpha] . Positive_regulation IFNA8 TLR7 15767370 1384088 Interleukin-1 receptor associated kinase-1 plays an essential role for and TLR9 mediated [interferon-{alpha] } *induction* . Positive_regulation IFNA8 TLR7 18806803 1969819 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Positive_regulation IFNA8 TLR7 19597505 2117985 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Positive_regulation IFNA8 TLR7 20684157 2299119 This drug elicits its immunological response by binding to on dendritic cells *inducing* the production of [interferon alpha (IFN-alpha)] and other inflammatory cytokines . Positive_regulation IFNA8 TLR7 24855048 2940682 By blocking the and 9 in plasmacytoid dendritic cells , HCQ *inhibits* [interferon-alpha] production which plays a crucial role in SLE pathogenesis . Positive_regulation IFNA8 TNF 1696166 137206 Both and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , [interferon (IFN)-alpha] , or IFN-gamma . Positive_regulation IFNA8 TNF 18050196 1833235 To address the hypothesis that blockade can *result* in increased levels of [interferon-alpha (IFNalpha)] and BAFF , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Positive_regulation IFNA8 TNF 20304804 2266028 Moreover , we have evidenced that ( 1 ) nanometric particles *induce* production of [interferon-alpha] , whereas ( 2 ) micrometric particles mainly induce production of in human immune cells . Positive_regulation IFNA8 TNFSF10 17617740 1815976 [Interferon-alpha] *induces* expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation IFNA8 TNFSF10 20663526 2305214 [Interferon-alpha] did not *induce* changes in or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation IFNAR1 TLR7 18083102 1834555 *induction* of [IFNAR-STAT1] signaling upregulates the TAM system , which in turn usurps the IFNAR-STAT1 cassette to induce the cytokine and TLR suppressors SOCS1 and SOCS3 . Positive_regulation IFNB1 CD14 10601848 655178 Important *role* of membrane associated in the induction of [IFN-beta] and subsequent nitric oxide production by murine macrophages in response to bacterial lipopolysaccharide . Positive_regulation IFNB1 CD14 19461481 2084816 We hypothesized that the TLR4 coreceptor , the intracellular adaptor proteins myeloid differentiation factor 88 ( MyD88 ) and TIR domain-containing-adaptor *inducing* [IFNbeta] ( TRIF ) would be required for cold I/R induced inflammation . Positive_regulation IFNB1 IL1B 15749911 1379787 We now show , using real-time PCR , that in astrocytes *induces* the expression of [IFN-beta] , IRF7 , CXCL10/IFN-gamma-inducible protein-10 , and CCL5/RANTES . Positive_regulation IFNB1 MMP28 12764058 1093932 Furthermore , the tetracycline minocycline , which has a known blocking effect in experimental autoimmune encephalomyelitis , an in vivo model of acute inflammation in multiple sclerosis , and other inhibitors *prevent* the in vitro degradation of [IFN-beta] by gelatinase B . Positive_regulation IFNB1 MMP7 12764058 1093947 Furthermore , the tetracycline minocycline , which has a known blocking effect in experimental autoimmune encephalomyelitis , an in vivo model of acute inflammation in multiple sclerosis , and other inhibitors *prevent* the in vitro degradation of [IFN-beta] by gelatinase B . Positive_regulation IFNB1 NT5E 18034430 1832564 [IFN-beta] also *induced* the expression and activity of and concurrently decreased vascular permeability in cultured human pulmonary endothelial cells . Positive_regulation IFNB1 NT5E 24503265 2914099 In ex-vivo studies , we first established that [IFN-beta-1a] *induced* up-regulation in cultured human lung tissue samples . Positive_regulation IFNB1 PECAM1 18025177 1827644 In this study , we demonstrate that ligation with CD38-Fc fusion protein negatively *regulates* LPS induced proinflammatory cytokine TNF-alpha , IL-6 , and [IFN-beta] production by inhibiting JNK , NF-kappaB , and IFN regulatory factor 3 activation in macrophages . Positive_regulation IFNB1 SMN2 11147573 760985 Here we show that both [IFN-beta] and IFN-gamma rapidly *induced* and SMNc mRNA and protein expression in various cell lines . Positive_regulation IFNB1 TLR7 12776992 1095481 Meanwhile , TLR3 , , and TLR9 can *induce* both IFN-alpha and [IFN-beta] . Positive_regulation IFNB1 TLR7 15699120 1372416 IFN-alpha regulates *dependent* gene expression of IFN-alpha , [IFN-beta] , IL-28 , and IL-29 . Positive_regulation IFNB1 TLR7 15699120 1372436 IFN-alpha also enhanced the expression of signaling molecules MyD88 , TIR domain containing adaptor *inducing* [IFN-beta] , IkappaB kinase-epsilon , receptor interacting protein 1 , and IFN regulatory factor 7 . Positive_regulation IFNB1 TLR7 16052631 1442001 Cytosolic components of NADPH oxidase suppressed mediated NF-kappaB activation as well as [IFN-beta] promoter *activation* . Positive_regulation IFNB1 TLR7 17082622 1643281 dependent *induction* of [IFN-beta] mediates host defense against Trypanosoma cruzi . Positive_regulation IFNB1 TLR7 17082622 1643301 These findings suggest that *dependent* expression of [IFN-beta] is involved in resistance to T. cruzi infection through the induction of IRG47 . Positive_regulation IFNB1 TLR7 17273997 1697138 These results demonstrate that *induce* IFN-alpha or [IFN-beta] responses by activating distinct IRF , depending on the TLR ligand and the cell type . Positive_regulation IFNB1 TLR7 17513736 1745693 Unexpectedly , however , IRF5 plays a critical role in IFN-alpha and [IFN-beta] production *induced* not only by RNA containing immune complexes but also by conventional and TLR9 ligands . Positive_regulation IFNB1 TLR7 17897860 1811289 TLR3 and TLR7 are involved in expression of IL-23 subunits while TLR3 but not is *involved* in expression of [IFN-beta] by Theiler 's virus infected RAW264.7 cells . Positive_regulation IFNB1 TLR7 18025224 1827724 However , the unique induction of [IFN-beta] by P. gingivalis LPS *requires* and IFNalphabetaR cosignaling , and the induction of ISRE containing gene is dependent on the activation of IFN-beta autocrine loop . Positive_regulation IFNB1 TLR7 18523265 1922813 CD45 regulates *induced* proinflammatory cytokine and [IFN-beta] secretion in dendritic cells . Positive_regulation IFNB1 TLR7 18758466 1962302 Thus , mTOR signaling is crucial in *mediated* [IFN-alpha/beta] responses by pDCs . Positive_regulation IFNB1 TLR7 19524994 2103207 We further demonstrate that the HCMV derived interleukin 10 (IL-10) homolog functions similar to cellular IL-10 and broadly inhibits induced transcriptional *activation* of [IFN-alpha/beta] genes in plasmacytoid dendritic cells ( PDCs ) , a major type I IFN-producer in vivo that is highly resistant to HCMV infection in vitro . Positive_regulation IFNB1 TLR7 19637227 2143058 Neonatal myeloid DC were shown to be deficient in [IFN-beta] and IL-12 synthesis in *response* to triggering . Positive_regulation IFNB1 TLR7 19667062 2132724 Here , we investigated the role of the TPL-2 signaling pathway in *induction* of [interferon-beta (IFN-beta)] and interleukin-10 (IL-10) in these cell types . Positive_regulation IFNB1 TLR7 20100929 2213015 SHIP-1-deficient macrophages display enhanced *induced* [IFN-beta] production , and overexpression of SHIP-1 negatively regulates the ability of TLR3 and its adaptor , Toll/IL-1 receptor domain containing adaptor inducing IFN-beta , to induce IFN-beta promoter activity , indicating that SHIP-1 negatively regulates TLR induced IFN-beta production . Positive_regulation IFNB1 TLR7 20200270 2229548 In *response* to signaling , conventional DCs can also produce [IFN-beta] but not IFN-alpha in a type I IFN independent manner . Positive_regulation IFNB1 TLR7 23234343 2757765 Stimulation of thyrocytes with ligands *resulted* in activation of the [interferon-beta] ( IFN-ß ) promoter and the nuclear factor kappa-light-chain-enhancer of activated B cells ( NF?B ) -dependent promoter . Positive_regulation IFNB1 TLR7 24956889 2947320 mediated mast cell stimulation *resulted* in cysteinyl leukotriene ( cysLT ) and [interferon (IFN)-beta] synthesis , whereas no histamine and CXCL8 secretion was stated . Positive_regulation IFNB1 TNF 11137135 769927 The differential effect of IFN-beta and TGF-b on IL-12 bioactivity was most pronounced upon IFN-gamma synthesis , since [IFN-beta] *induced* only marginal amounts of IL-10 and IL-12 and TGF-beta diminished constitutive IL-10 production , while neither had a significant effect on production . Positive_regulation IFNB1 TNF 1292634 207777 Since also *induces* [IFN-beta] in these cells and the latter cytokine itself has the capacity to upregulate HLA class I expression , we investigated the role of autocrine IFN-beta in the induction of HLA-B7 by TNF . Positive_regulation IFNB1 TNF 1292634 207779 The latter findings support the idea that induction of HLA class I by TNF is not mediated solely by autocrine [IFN-beta] produced in *response* to . Positive_regulation IFNB1 TNF 14519761 1174278 Using neutralizing antibodies to IFNbeta and TNFalpha receptor 1 , we show that *induced* secretion of [IFNbeta] mediated gamma activated site dependent gene expression via activation of TNFalpha receptor 1 . Positive_regulation IFNB1 TNF 17172979 1679426 Vascular dysfunction induced by E. coli requires TLR4 but has no requirement for TLR2 , TLR1 , TLR6 , or , and a partial but incomplete requirement of MyD88 and TIR domain containing adapter *inducing* [interferon-beta] . Positive_regulation IFNB1 TNF 17266037 1718158 However , regarding cancer as a non-linear system , which may , even in the absence of an apparent selection pressure , fluctuate between different `` metastable '' phenotypes , we demonstrate that *mediated* [IFN-beta] induction is not irreversibly disturbed in all cells . Positive_regulation IFNB1 TNF 18345002 1886673 *induced* [interferon-beta] production depended on interferon-response factor 1 , and downstream gene expression was mediated by synergy between small amounts of interferon-beta and canonical TNF induced signals . Positive_regulation IFNB1 TNF 1846503 151690 Our results are in accordance with the idea that *induces* [IFN beta] 1 and that both cytokines must be present in the culture medium to synergize with IFN gamma in order to inhibit HSV-1 replication . Positive_regulation IFNB1 TNF 2167923 140247 Furthermore functions to *enhance* the existing [IFN-beta] activity . Positive_regulation IFNB1 TNF 2448553 82347 This suggested the *induction* of [IFN-beta] by . Positive_regulation IFNB1 TNF 2474237 103989 *induced* transcription of [IFN-beta] 2 in resistant variants , indicating that this cytokine does not contribute to the antiviral activity of TNF . Positive_regulation IFNB1 TNF 2550437 117573 Our results support the conclusion that autocrine [IFN-beta] is secreted by untreated normal fibroblasts and that can *enhance* the production of autocrine IFN-beta by increasing the level of IFN-beta mRNA . Positive_regulation IFNB1 TNF 2852914 102516 Synergy of antiviral actions of TNF and IFN-gamma : evidence for a major role of *induced* [IFN-beta] . Positive_regulation IFNB1 TNF 2871942 59231 We also show that antiserum to IFN-beta enhanced the mitogenic effect of TNF in confluent , serum starved human fibroblasts , suggesting that *induction* of [IFN-beta] by represents a physiological negative feedback mechanism regulating cell proliferation . Positive_regulation IFNB1 TNF 3108877 73540 The *enhancement* of [IFN-beta] 2 gene expression by diC8 , interleukin 1 , or was not prevented by H8 , a preferential inhibitor of cAMP- and cGMP dependent protein kinases , but was blocked by H7 , an inhibitor of protein kinase C as well as of cyclic nucleotide dependent protein kinases . Positive_regulation IFNB1 TNF 3538015 66151 Polyclonal and monoclonal anti-IFN-beta antibodies inhibit the increase in class I HLA gene expression ( HLA-B7 mRNA ) in TNF treated FS-4 cells suggesting that *induced* [IFN-beta] 2 mediates the enhancing effect of TNF on HLA gene expression in human fibroblasts . Positive_regulation IFNB1 TNF 7729535 302161 [Interferon-beta (IFN-beta)] at concentrations of 10 , 100 , and 1000 IU/ml in the *presence* of significantly increased the ICAM-1 expression of fibroblasts in a dose dependent manner . Positive_regulation IFNB1 TNFSF10 11410525 826447 In resistant A375 cells , [IFN-beta] did not *induce* expression . Positive_regulation IFNB1 TNFSF10 11677236 896116 Interestingly , while we observed interferon mediated up-regulation of TRAIL , we also demonstrated a concomitant *mediated* induction of [interferon-beta] . Positive_regulation IFNB1 TNFSF10 11896621 922819 [IFN-beta] , but not gamma-irradiation , *induced* in NIH-OVCAR-3 cells . Positive_regulation IFNB1 TNFSF10 17892398 1802558 was not *induced* by [IFN-beta] in mutant cell lines U2A , U3A , U4A , U5A , and U6A , which lack , respectively , IFN regulatory factor-9 (IRF-9) , Stat1 , Jak1 , IFNAR-2 .2 , and Stat2 , indicating transcription factor IFN stimulated gene factor 3 (ISGF3) was essential for the induction of this gene . Positive_regulation IFNE TNF 17878351 1796912 Our findings support a sequential mechanism whereby *leads* to stabilization of IFN-epsilon mRNA , increased [IFN-epsilon] synthesis , engagement of type I IFNRs , increased STAT1 expression and phosphorylation , and up-regulation of RIG-I expression . Positive_regulation IFNG ABCA4 11809739 906512 Interestingly , [IFN-gamma] *induced* and augmented NO generation with decreased production of IL-6 , whilst IL-4 induced OMp and augmented IL-6 production . Positive_regulation IFNG CAPN8 11119528 768415 Considering our observation of elevated expression of inducible nitric oxide synthase mRNA in immunized mice , *induced* [IFN-gamma] seemed to upregulate the production of nitric oxide by macrophages and subsequently mediated the killing of schistosomulae in the lung . Positive_regulation IFNG CAPN8 18211896 1895473 [IFNgamma] *induced* expression and activation and increased the phosphorylation and degradation of the calpain substrate ABCA1 in 1542CP3TX cancer cells . Positive_regulation IFNG CCL17 20022349 2241202 In this study , we investigated whether and CCL28 transcription in cultured keratinocytes is *induced* by TNF-alpha , IL-1beta , or [IFN-gamma] . Positive_regulation IFNG CHI3L1 16357325 1539700 In contrast , expression of was *induced* by [IFNgamma] and suppressed by dexamethasone . Positive_regulation IFNG EDN2 9536126 497472 In addition , when pMO were stimulated by [interferon-gamma (IFN-gamma)] in the *presence* of , a significant inhibition of IL-6 and IL-1 production was observed compared with the effects of the same doses of IFN-gamma or ET-2 used separately . Positive_regulation IFNG EGLN3 19574556 2122220 [IFNgamma] and , to a lesser extent , IFNalpha significantly *induced* , but not PHD1 or 2 , mRNA , and protein expression selectively in ECs directly via a JAK/STAT1 pathway as demonstrated by pharmacological inhibition , siRNA knockdown , and chromatin immunoprecipitation . Positive_regulation IFNG EGLN3 19574556 2122222 [IFNgamma] *induces* through a JAK/STAT1 dependent mechanism in human ECs . Positive_regulation IFNG EPHB2 10601128 574187 Tumor necrosis factor-alpha (TNF-alpha) alone can induce extracellular signal regulated kinase ( ERK ) , p38 MAPK , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas [interferon-gamma (IFN-gamma)] can *induce* only . Positive_regulation IFNG EPHB2 16785500 1577081 In macrophages , LPS inhibited IFN-gamma-inducible CIITA and MHC class II expression without affecting expression of IFN regulatory factor-1 and MHC class I. Blocking and p38 by MAPK inhibitors not only rescued LPS mediated inhibition , but also *augmented* [IFN-gamma] induction of CIITA . Positive_regulation IFNG EPHB2 16951314 1610456 Experiments with ERK-1/2 inhibitors demonstrated that bryostatin-1 induction of [IFN- gamma] and T-bet was *dependent* and IL-12 independent . Positive_regulation IFNG EPHB2 17804388 1791122 Also , secretion of [IFN-gamma] was *dependent* on , p38 MAPK , p70 ( S6 ) kinase , and NF-kappaB , but not on calcineurin . Positive_regulation IFNG EPHB2 18174382 1889895 Studies with specific chemical inhibitors revealed that the activation of was dependent on the activation of PI3-K , whose activation was dependent on Syk , and that sequential activation of these molecules was *required* for NK cell [IFN-gamma] production in response to FcR and IL-12 stimulation . Positive_regulation IFNG EPHB2 9233612 445084 The *requirement* for signaling for maximal [IFN-gamma] synthesis could nevertheless be demonstrated in both populations by blockade with the inhibitor PD98509 . Positive_regulation IFNG EPHB2 9763606 537141 Integrin mediated signaling *regulates* [interferon gamma] production in human natural killer cells . Positive_regulation IFNG FAS 10070035 594256 [IFN-gamma] *increases* expression of on HT-29 cells . Positive_regulation IFNG FAS 10200533 561155 [IFN-gamma] *induced* an upregulation of receptor expression and pre-treatment of cells with IFN-gamma led to enhanced anti-Fas mediated cell death . Positive_regulation IFNG FAS 10845905 700697 [IFN-gamma] *induced* expression of the cells without the activation of caspase8 or caspase3 during 16 hours of incubation , while deprivation of EPO induced expression of Fas and the activation of both caspase8 and caspase3 . Positive_regulation IFNG FAS 10895367 711571 Our findings suggest that [IFN-gamma] or TNF-alpha secreted by infiltrating lymphocytes *induces* ductal expression and ductal apoptosis in sialoadenitis associated with SS . Positive_regulation IFNG FAS 11104808 756537 engagement *induces* the maturation of dendritic cells (DCs) , the release of interleukin (IL)-1beta , and the production of [interferon gamma] in the absence of IL-12 during DC-T cell cognate interaction : a new role for Fas ligand in inflammatory responses . Positive_regulation IFNG FAS 12480581 1024223 [IFN-gamma] *induced* expression up-regulation and tumor cell apoptosis in a time dependent manner . Positive_regulation IFNG FAS 12700648 1082040 Blocking TRAIL and significantly *enhance* [IFN-gamma] production in vitro . Positive_regulation IFNG FAS 15123769 1272993 [IFN-gamma] *induced* an increase in the expression of and FasL by allergen stimulated CD4+ T cells from asthmatic patients and caused the apoptosis of these cells . Positive_regulation IFNG FAS 15331352 1287886 This difference in IL-10 KO mice was associated with an *increase* in serum tumor necrosis factor-alpha and [interferon-gamma] levels and with an increase in expression on fresh , isolated , small intestinal epithelial cells . Positive_regulation IFNG FAS 18567840 1946408 Neutrophil depletion prevented tumor regression as well as enhanced [IFN-gamma] production *induced* by . Positive_regulation IFNG FAS 19002429 2022198 In INS-1 cells , IL-1beta + [IFN-gamma] *induced* a tenfold and eightfold increase of mRNA expression after 6 and 24 h , respectively . Positive_regulation IFNG FAS 7538820 306902 antigen expression on CD34+ human marrow cells is *induced* by [interferon gamma] and tumor necrosis factor alpha and potentiates cytokine mediated hematopoietic suppression in vitro . Positive_regulation IFNG FAS 7542501 314116 However , [IFN-gamma] and/or TNF-alpha *induced* the expression of both the mRNA of Fas and itself in a dose dependent fashion on the surface of CD34+ cells after 48 hours of serum-free culture . Positive_regulation IFNG FAS 7542501 314127 These observations indicate that [IFN-gamma] and/or TNF-alpha , well known as negative hematopoietic regulators , *induce* functional on hematopoietic progenitor cells . Positive_regulation IFNG FAS 7693996 234257 Expression of was *induced* in phytohemagglutinin activated T cells and in a mammary carcinoma cell line by [interferon-gamma] alone and in combination with tumor necrosis factor alpha . Positive_regulation IFNG FAS 8741668 377115 However , [interferon-gamma(IFN-gamma)] and/or tumor necrosis factor-alpha (TNF-alpha) *induced* the expression of after 48 hours of serum-free culture . Positive_regulation IFNG FAS 9028327 413476 We have previously shown that [IFN-gamma] *induces* expression on CD34+ cells ; Positive_regulation IFNG FAS 9049961 406022 However , [interferon-gamma (IFN-gamma)] and/or tumor necrosis factor-alpha (TNF-alpha) *induced* dose dependent expression of both Fas mRNA and protein on the surface of CD34+ cells after 48 hours of serum-free culture . Positive_regulation IFNG FAS 9389691 467163 [IFN-gamma] both inhibits cell cycling and *induces* expression of the , resulting in subsequent apoptosis of hematopoietic progenitor cells . Positive_regulation IFNG FAS 9661898 518181 [IFN-gamma] induces cell growth inhibition by Fas mediated apoptosis : *requirement* of STAT1 protein for up-regulation of and FasL expression . Positive_regulation IFNG FAS 9743345 532390 Differential expression of and Fas ligand in acute and chronic graft-versus-host disease : up-regulation of Fas and Fas ligand *requires* CD8+ T cell activation and [IFN-gamma] production . Positive_regulation IFNG GPNMB 17475886 1738533 is *induced* in macrophages by [IFN-gamma] and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses . Positive_regulation IFNG HRH1 15021962 1221740 Depletion of the *resulted* in decreases in the release of IL-2 and IL-10 from both CD4+ and CD8+ cells and increases in the release of IL-4 from CD4+ T cells and [IFN-gamma] from CD8+ cells . Positive_regulation IFNG HRH1 17965772 1820334 is *required* for TCR mediated p38 MAPK activation and optimal [IFN-gamma] production in mice . Positive_regulation IFNG HRH1 17965772 1820347 Here we showed that expression of in naive CD4+ T cells was *required* for maximal [IFN-gamma] production but was dispensable for proliferation . Positive_regulation IFNG ID1 17012234 1641404 Consistently , c-rel deficiency diminishes tumor necrosis factor alpha and [interferon-gamma] expression *induced* by and TCR signaling . Positive_regulation IFNG IL1B 10584410 570975 The spontaneous or [IFN-gamma] +TNF-alpha <+IL-1 beta> *induced* IL-8 release was significantly augmented after the addition of neutrophils . Positive_regulation IFNG IL1B 10653850 663315 Here we show that IL-12 and synergistically *induce* T cells to proliferate and produce [IFN-gamma] without their TCR engagement . Positive_regulation IFNG IL1B 10653850 663317 We also show that T(h)1 cells but not T ( h ) 2 cells have increased expression of IL-18R and IL-1R , and produce [IFN-gamma] in *response* to IL-18 and/or . Positive_regulation IFNG IL1B 10681439 669149 Consistent with these observations , IL-12 , a known inducer of IFN-gamma , augmented *induced* [IFN-gamma] but suppressed IL-1beta induced PGE ( 2 ) by 75 % . Positive_regulation IFNG IL1B 11735275 885762 MIN6 cells were cultured in the *presence* of , TNFalpha , and/or [IFN gamma] . Positive_regulation IFNG IL1B 11920321 926087 The *role* of endogenous interleukin (IL)-18 , IL-12 , , and tumor necrosis factor-alpha in the production of [interferon-gamma] induced by Candida albicans in human whole-blood cultures . Positive_regulation IFNG IL1B 11971025 933509 We found that PPAR alpha ligands ( clofibrate and WY14643 ) enhanced IL-1 beta induced COX-2 expression in human astrocytes and microglia , while inhibiting plus [IFN-gamma] *induction* of iNOS in astrocytes . Positive_regulation IFNG IL1B 1444189 205130 GM-CSF as well as D3 and [IFN-gamma] *induced* production by the HL-60 cells , clearly indicating their importance in differentiation of these cells . Positive_regulation IFNG IL1B 14630716 1210047 In the present study , we show that an octamer motif located 20 bp downstream of the proximal NF-kappa B binding site in the rat iNOS promoter is critical for and [interferon-gamma] *induction* of promoter activity in rat primary beta-cells and insulin producing RINm5F cells . Positive_regulation IFNG IL1B 14632664 1170695 Mitogen stimulation of embryonic day 18 and day 1 post-hatch thymocytes *induced* up-regulation of [IFN-gamma] , IL-1beta and TGF-beta transcripts , and down-regulation of IFN-alpha , IFN-beta and IL-2 transcripts , with a higher induction of IFN-gamma , and TGF-beta transcripts in more immature T-cell-receptor negative ( TCR- ) than TCR+ ( TCR1+ , TCR2+ , or TCR3+ ) subsets . Positive_regulation IFNG IL1B 1517568 196856 In THP-1 cells , [IFN-gamma] *induces* cell surface expression of HLA-DR and CD54 and production of , TNF-alpha , and IL-6 . Positive_regulation IFNG IL1B 15597792 1346558 TNF augments inflammation , TNF and [IFN-gamma] induce coagulation , and *induces* coagulation and fibrinolysis . Positive_regulation IFNG IL1B 16426148 1515716 Furthermore , increases in [IFN-gamma receptors (IFNGR)] *induced* by were found to be dependent on NF-kappaB transactivation . Positive_regulation IFNG IL1B 16544114 1611830 Statistically increased levels of TNF-alpha and were detected in the experimental vitreous with maximum levels observed at 12 h . [IFN-gamma] was also *detected* in the experimental vitreous and reached maximum levels at 48 h . Positive_regulation IFNG IL1B 17058806 1636896 alone significantly *induced* IL-12 production in DCs , whereas TNF-alpha or [IFN-gamma] induced modest levels of IL-12 production . Positive_regulation IFNG IL1B 17484771 1778189 LPS induced production of tumour necrosis factor-alpha (TNF-alpha) , interleukin-6 (IL-6) , IL-10 and [interferon-gamma-inducible] protein-10 (IP-10); SA *induced* TNF-alpha , and production ; Positive_regulation IFNG IL1B 17641013 1771220 Recombinant trout IL-15 preferentially stimulated splenic leukocytes from healthy fish , where it *induced* a large increase in [IFN-gamma] expression , with little , if any , effect on expression . Positive_regulation IFNG IL1B 18239058 1877024 Human pancreatic periacinar myofibroblasts expressed IL-32alpha in *response* to , TNF-alpha , and [IFN-gamma] . Positive_regulation IFNG IL1B 18805021 1987117 A synergistic *role* for and TNFalpha in monocyte derived [IFNgamma] inducing activity . Positive_regulation IFNG IL1B 18805021 1987120 Moreover , size-fractionation of the monocyte conditioned media dramatically reduced the [IFNgamma] *inducing* activity of , suggesting that IL-1beta requires a cofactor to induce IFNgamma production in KG-1 cells . Positive_regulation IFNG IL1B 18805021 1987121 Furthermore , rTNFalpha restored the [IFNgamma] *inducing* activity of the size fractionated . Positive_regulation IFNG IL1B 19117633 2025034 ONO-1714 significantly reduced cytokine mediated cytotoxicity and NO production in both MIN6N9a cells and C57BL/6 islets in the *presence* of , TNF-alpha , and [IFN-gamma] . Positive_regulation IFNG IL1B 19700144 2133274 Also , the presence of exogenous [IFN-gamma] in the growth medium significantly *induced* IL-6 , but not or TNF-alpha , in D1 and D2 cells . Positive_regulation IFNG IL1B 19707556 2127274 NFkappaB inhibition resulted in decreased *stimulated* [IFNgamma] release . Positive_regulation IFNG IL1B 20027291 2175569 Supernatants of Salmonella infected Mphi1 contained more IL-18 and as compared with supernatants of Mphi1 stimulated with isolated TLR agonists , and *induced* [IFN-gamma] production in human CD56 ( + ) cells in an IL-23 and IL-1beta dependent but IL-12 independent manner . Positive_regulation IFNG IL1B 2111375 132927 Recombinant [interferon-gamma] ( rIFN gamma ) alone did not *induce* secretion and did not significantly increase secretion by LPS- and silica stimulated cells . Positive_regulation IFNG IL1B 7506700 244435 These findings suggest that [interferon gamma] directly *induces* the expression of the inducible nitric oxide synthase gene , whereas tumor necrosis factor-alpha and induce it , at least in part , via the induction of intermediary protein ( s ) , and that transforming growth factor-beta 1 inhibits cytokine induced nitric oxide production by blocking the posttranscriptional synthesis of inducible nitric oxide synthase . Positive_regulation IFNG IL1B 7594594 325883 is *required* for IL-12 to induce production of [IFN-gamma] by NK cells . Positive_regulation IFNG IL1B 7594594 325886 In this report we demonstrate that is *required* for IL-12 to stimulate production of [IFN-gamma] by NK cells , and that IL-1 is important in IL-12 mediated resistance to T. gondii in vivo . Positive_regulation IFNG IL1B 7594594 325892 Stimulation of SCID mouse splenocytes with or IL-1 alpha did not *result* in production of [IFN-gamma] but enhanced remarkably the ability of T. gondii or IL-12 to stimulate production of IFN-gamma . Positive_regulation IFNG IL1B 8093434 210051 Furthermore , *synergized* with IL-2 by increasing intracellular as well as cell-free levels of [IFN-gamma] in cultures of unfractionated tonsillar MNC . Positive_regulation IFNG IL1B 8638287 342967 IL-2 , IL-6 , IL-8 , TNF-alpha , TNF-beta and [IFN-gamma] , but not IL-1 alpha , were *detected* in the monkey using human reagents . Positive_regulation IFNG IL1B 9178691 434230 ISMCs were analyzed for class II major histocompatibility complex ( MHC ) , intercellular adhesion molecule 1 ( ICAM-1 ) , and B7 before and after exposure to [interferon gamma] ( IFN-gamma ; 100 or 1000 U/ mL ) in the *presence* or absence of ( 10 ng/mL ) or TNF-alpha ( 5 ng/mL ) for 72 hours . Positive_regulation IFNG IL1B 9213252 441572 C4 secretion was *induced* by [IFN-gamma] , whereas factor B secretion was induced by , TNF-alpha , or IFN-gamma . Positive_regulation IFNG IL1B 9244174 407976 Quantitative reverse transcription-polymerase chain reaction indicated that the m-RNA level was not increased by [interferon-gamma] but was synergistically *increased* by interferon-gamma plus . Positive_regulation IFNG IL1B 9500699 490949 In a system of rat hepatocytes in primary culture , *induced* production of both NO and [IFN-gamma] . Positive_regulation IFNG ITGAL 11882913 919657 Essential *role* of interaction in synergistic effect of IL-18 and IL-12 on [IFN-gamma] production in human PBMC . Positive_regulation IFNG ITGAL 1358968 200425 Anti-CD3 plus stimulation consistently *induced* the highest secretion of IL-2 and [IFN-gamma] , whereas variation in secretion of TNF-alpha and IL-4 between different donors was noted . Positive_regulation IFNG ITGB2 16455966 1522315 Abrogation of HuR function by use of inhibitory peptides , or marked reduction of HuR levels by RNA interference , prevents engagement *mediated* stabilization of T cell TNF-alpha or [IFN-gamma] transcripts , respectively . Positive_regulation IFNG ITGB2 3923098 49075 Specifically , macrophage activating factor (MAF) , [interferon-gamma (IFN-gamma)] , or picogram amounts of endotoxin ( LPS ) *induced* on TG-elicited macrophages following overnight incubation . Positive_regulation IFNG JAG1 11390498 822550 [IFN-gamma] secretion in *response* to H. pylori was correlated with gastritis , although splenocytes from all groups of mice secreted some IFN-gamma . Positive_regulation IFNG JAG1 15067068 1231789 Moreover , the production of [IFN-gamma] in *response* to parasite was significantly increased in spleen cells from anti-CTLA-4 treated infected mice when compared with the production found in cells from IgG treated infected mice . Positive_regulation IFNG JAG1 16818743 1581291 In contrast , Delta1 knockdown in CD4 ( + ) T cells selectively *enhanced* production of [IFN-gamma] , IL-2 , and IL-5 in response to polyclonal stimulation , while or Jagged2 knockdown had no effect . Positive_regulation IFNG JAG1 17475837 1738420 CD8+ T cells from rejector mice did not produce [IFN-gamma] in *response* to Ad5E1 tumor or use FasL to mediate intraocular tumor rejection . Positive_regulation IFNG JAG1 17785869 1790839 As a result , the production of [IFN-gamma] *induced* in T cells by both was seven to eight times greater in very old than in young subjects . Positive_regulation IFNG JAG1 9233629 445110 gamma delta T cells were found to rapidly expand and produce [IFN-gamma] in *response* to nonpeptide . Positive_regulation IFNG JAG1 9233629 445116 In contrast , gamma delta T cells from the majority of HIV+ donors did not expand or express [IFN-gamma] in *response* to nonpeptide , even in the presence of IL-12 . Positive_regulation IFNG JAG1 9574535 502518 Human gamma delta T cells have the ability to rapidly expand and produce [IFN-gamma] in *response* to nonpeptide of microbial pathogens , in particular a class of compounds known as the prenyl phosphates . Positive_regulation IFNG KLF9 10605024 655612 The *role* of Sp family members , basic , and E box factors in the basal and [IFN-gamma] regulated expression of the human complement C4 promoter . Positive_regulation IFNG MAP2K6 9582275 503819 In contrast , activation of the p38 MAP kinase pathway by the expression of constitutivelyactivated in transgenic mice *caused* increased production of [IFNgamma] during the differentiation and activation of Th1 cells . Positive_regulation IFNG MUC16 8812537 383378 [IFN-gamma] , on the other hand , *induced* a highly significant increase in secretion in ovarian cancer cells , but did not influence the shedding of CA-125 in HPMCs . Positive_regulation IFNG PLA2G2A 10811652 714639 [Interferon-gamma] *induces* secretory in human arterial smooth muscle cells . Positive_regulation IFNG RGS16 14566449 1165127 IL-1beta ( 1.75-fold ) and TNFalpha ( 1.62-fold ) but not IL-6 and [IFNgamma] *induced* protein expression . Positive_regulation IFNG SELL 10529600 561976 [Interferon-gamma] *increases* expression on human eosinophils . Positive_regulation IFNG SMN2 11147573 760992 Here we show that both IFN-beta and [IFN-gamma] rapidly *induced* and SMNc mRNA and protein expression in various cell lines . Positive_regulation IFNG SPHK1 11936187 894672 Apparently , activity is also *involved* in [IFN-gamma] induced calcium signals . Positive_regulation IFNG SPHK1 18602364 1941485 In this study , to elucidate whether is *involved* in IL-18 induced [IFN-gamma] production , we measured IL-18 induced IFN-gamma production after pre-treatment with SPHK inhibitor (SKI) in NK-92MI cells . Positive_regulation IFNG SPHK1 18602364 1941520 Inhibition of by SKI also *inhibited* IL-18 induced [IFN-gamma] production in human primary NK cells . Positive_regulation IFNG SPRR1B 18172072 1855836 IL1alpha , IL1beta , IL6 , [IFNgamma] , and TNFalpha *induced* expression in vitro and the local expression of IL1beta and IFNgamma was elevated in ocular tissues of patients with SS and aire-deficient mice . Positive_regulation IFNG SRGN 15450130 1300672 Stimulation with *induced* the secretion of both IL-13 and [IFN-gamma] , influenced by time and dose in neonates , adults , and mice . Positive_regulation IFNG STAT4 10903740 713057 We and others have demonstrated that the is *critical* for [IFN-gamma] production by activated T cells and Th1 cells . Positive_regulation IFNG STAT4 10946290 722941 However , other signaling pathways can be used to bypass *dependent* production of [IFN-gamma] and enhance innate resistance to T. gondii . Positive_regulation IFNG STAT4 11034424 740759 These findings demonstrate that the activation of alone is not *sufficient* for IL-12 induced [IFN-gamma] production and proliferation and suggest that other STATs play a role in these responses to IL-12 . Positive_regulation IFNG STAT4 11120802 758227 Since the precise *role* of in [IFN-gamma] induction has not been established , experiments were conducted to examine Stat4 activation of IFN-gamma and other genes required for cytokine induced expression of IFN-gamma . Positive_regulation IFNG STAT4 11207258 786865 The production of [IFN-gamma] by IL-12/IL-18 activated macrophages *requires* signaling and is inhibited by IL-4 . Positive_regulation IFNG STAT4 11466347 839906 An absolute requirement for and a *role* for [IFN-gamma] as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex . Positive_regulation IFNG STAT4 12213961 985802 We demonstrated that expression of wild-type , but not the S721A mutant , *restored* normal T(H)1 differentiation and [IFN-gamma] synthesis . Positive_regulation IFNG STAT4 12242445 989980 Here we show that IFN-alpha/beta activate directly ( STAT , signal transducers and activators of transcription ) and that this is *required* for [IFN-gamma] production during viral infections of mice , in concert with T cell receptor derived signals . Positive_regulation IFNG STAT4 12370359 995878 was *critical* for NK cell [IFN-gamma] expression , whereas IFN-alphabeta/STAT1 were required for induction of cytotoxicity . Positive_regulation IFNG STAT4 12925694 1131491 An immune response also induced in the brain of the GIFN/STAT2-/- mice was associated with [IFN-gamma] gene expression by CD3+ T cells and the *activation* of the STAT1 , STAT3 , , and STAT5 molecules . Positive_regulation IFNG STAT4 14734615 1199399 A mechanism underlying *mediated* up-regulation of [IFN-gamma] induction inTCR triggered T cells . Positive_regulation IFNG STAT4 15307169 1284812 In summary , these results suggest that in contrast to IL-12 , IFN-alphaA does not play a functionally significant role in meditating the *dependent* induction of Th1 development or [IFN-gamma] production in CD4+ T cells . Positive_regulation IFNG STAT4 15728489 1377239 The IL-2-plus-IL-18 or IL-12-plus-IL-18 effect on [IFN-gamma] and IL-13 expression is *dependent* on and NF-kappaB but independent of Stat6 , T-bet , or NFAT . Positive_regulation IFNG STAT4 15817683 1432430 [IFN-gamma] production in response to IL-12 plus IL-18 did not *require* increased expression of but was dependent on the activity of p38 mitogen activated protein kinase (MAPK) . Positive_regulation IFNG STAT4 15879087 1406002 Conversely , enforced expression of partly *prevented* TGF-beta1 's inhibition of [IFN-gamma] expression during priming , but did not prevent TGF-beta1 's inhibition of Th1 development . Positive_regulation IFNG STAT4 16301617 1485127 , which plays a pivotal role in Th1 immune responses , *enhances* [IFN-gamma] transcription in response to the interaction of IL-12 with the IL-12R . Positive_regulation IFNG STAT4 16949558 1654169 We have previously reported that IL-12Rbeta1 signaling increases CVB3 induced myocarditis and IL-1beta/IL-18 levels in males , while IL-12 ( p35 ) *induced* [IFN-gamma] does not alter the severity of acute disease . Positive_regulation IFNG STAT4 17015705 1629844 However , in differentiated Th1 cells , IFN-alpha can induce transient , but not sustained , phosphorylation and , in synergy with IL-18 , can *induce* transient , but not sustained , [IFN-gamma] production in Th1 cells , in contrast to the sustained actions of IL-12 . Positive_regulation IFNG STAT4 9558063 499988 These data suggest that both AP-1 and are *required* for IL-12 dependent [IFN-gamma] promoter activity , whereas IL-18 causes direct activation via AP-1 . Positive_regulation IFNG TGM2 12162878 972253 [IFN-gamma] *induces* expression in rat small intestinal cells . Positive_regulation IFNG TLR7 16034103 1436345 mediated activation of human NK cells *results* in accessory cell dependent [IFN-gamma] production . Positive_regulation IFNG TLR7 16439962 1534180 Similarly , activation of on XS52 before UV-light exposure also *prevented* the UV-induced loss of [IFN-gamma] triggering in T cells during an allogeneic mixed lymphocyte reaction . Positive_regulation IFNG TLR7 16670332 1558537 However , purified uNK cells did not respond directly to TLR agonists , but [IFN-gamma] was produced by uNK cells in *response* to stimulation when cocultured with APCs . Positive_regulation IFNG TLR7 17289654 1698479 The tlr2 ( -/- ) or tlr7 ( -/- ) NK cells could not produce [IFN-gamma] in *response* to IL-12 plus TLR2 or ligands , respectively , indicating requirement of the corresponding TLRs . Positive_regulation IFNG TLR7 17570328 1753761 like TLR4-TLR7/8 synergistically *up-regulated* [IFN-gamma] but not IL-12 . Positive_regulation IFNG TLR7 17804388 1791116 Engagement of TLR3 , , and NKG2D *regulate* [IFN-gamma] secretion but not NKG2D mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12 . Positive_regulation IFNG TLR7 17918201 1819370 In this study , we investigated which mouse B cell subsets are the most potent cytokine producers , and examined the *role* of in the control of secretion of IL-6 , IL-10 , IL-12 and [IFN-gamma] by B cells . Positive_regulation IFNG TLR7 17918201 1819450 Thus , in *response* to combined stimulation , or via phorbol esters , [IFN-gamma] was secreted . Positive_regulation IFNG TLR7 18782351 2012115 Thus , MyD88 dependent innate immune responses induced by L. pneumophila involve both *dependent* responses and IL-18R dependent production of [IFN-gamma] by natural killer cells , and these MyD88 dependent pathways can function independently to provide host protection against an intracellular pathogen . Positive_regulation IFNG TLR7 19436711 2078009 [IFN-gamma] production by NKT cells *requires* the presence of CD1d and simultaneously receptor signalling through MyD88 and secretion of IL-12 . Positive_regulation IFNG TLR7 19710464 2133441 Moreover *induced* Vgamma9Vdelta2 [IFN-gamma] noncytolytic response led to efficient DC polarization into IL-12p70 producing cells . Positive_regulation IFNG TLR7 19954299 2172425 Increased expression of in CD8 ( + ) T cells *leads* to TLR7 mediated activation and accessory cell dependent [IFN-gamma] production in HIV type 1 infection . Positive_regulation IFNG TLR7 20709948 2312817 AMWAP transcription was rapidly induced in BV-2 microglia upon *stimulation* with multiple ligands and [IFN-gamma] . Positive_regulation IFNG TLR7 21487893 2463683 To clarify the functional characteristics of cord blood ( CB ) NK cells , we examined the capacity of CB NK cells to produce [interferon gamma] ( IFN-? ) in *response* to the ligands . Positive_regulation IFNG TLR7 22968409 2673556 The results demonstrated that chicken CD4+ and CD8+ T-cells express and that the various isolates of lactobacilli differentially *induces* the expression of interleukin 10 , [interferon-gamma] and transforming growth factor beta . Positive_regulation IFNG TNF 10207167 606795 In this study , we demonstrate that activated T cells from patients with XHIM produce markedly reduced levels of [IFN-gamma] , fail to induce antigen presenting cells to synthesize IL-12 , and *induce* greatly reduced levels of . Positive_regulation IFNG TNF 10332965 614911 IL-10 exerted inhibitory effects on both CD40 ligation induced and CD40 ligation plus [IFN-gamma] *induced* production by ST cells . Positive_regulation IFNG TNF 10374812 623135 The T helper 1-type cytokine [interferon-gamma (IFN-gamma)] *induced* TNF transcripts , but not secretion , and suppressed LPS induced IL-10 mRNA and secretion by microglia . Positive_regulation IFNG TNF 10548204 564846 Unstimulated HUVECs did not produce detectable amounts of TNF-alpha , but [IFN-gamma] , IL-1beta , and LPS when added together *induced* production of HUVECs in a time dependent manner . Positive_regulation IFNG TNF 10548204 564850 [IFN-gamma] , IL-1beta , or LPS alone did not *induce* production , whereas IFN-gamma and IL-1beta in combination were able to induce TNF-alpha production to some extent , and the production could be further increased with LPS . Positive_regulation IFNG TNF 10721095 579369 For example we have found that *enhances* [IFN-gamma] induced IDO activity and antimicrobial effect in human glioblastoma cells whereas both IFN-gamma mediated effects were blocked by TNF-alpha as well as by IL-1 in a human uroepithelial cell line . Positive_regulation IFNG TNF 10843686 700140 [IFN-gamma] induction of murine I-TAC is markedly *enhanced* by costimulation with LPS or IL-1beta in RAW cells and by in both RAW cells and Swiss 3T3 fibroblasts . Positive_regulation IFNG TNF 11001546 734539 Human recombinant ( 25 ng/mL ) added during the activation culture *resulted* in a two-fold increase in [interferon-gamma] release ( type 1 response ) and a significant reduction of interleukin-10 ( type 2 response ) after tumor antigen stimulation . Positive_regulation IFNG TNF 11062761 746745 In this study , [IFN gamma] *induced* a marked increase in Tf synthesis by macrophages , while IL-1 , IL-6 and produced a more modest increase . Positive_regulation IFNG TNF 11157054 780714 Initial comparisons indicated that alpha induction of epithelial intercellular adhesion molecule 1 *required* sequential induction of interleukin (IL)-12 ( p70 ) and [interferon gamma] , and unexpectedly localized IL-12 production to airway epithelial cells . Positive_regulation IFNG TNF 11447182 835538 SEB induced IFN-gamma was significantly inhibited only by anti-IL-12 antibodies , indicating that endogenous IL-18 , IL-1 , and are not *required* for SEB induced [IFN-gamma] . Positive_regulation IFNG TNF 11678640 873676 PECAM-1 was also constitutively expressed on microvascular endothelial cells MvE and GEC , but at lower levels than on HUVEC , and expression by these cells also decreased in *response* to and [IFN-gamma] . Positive_regulation IFNG TNF 11777537 899646 However , while merozoites plus [IFN-gamma] *induced* mRNA expression in MDM , NO was not produced . Positive_regulation IFNG TNF 11920321 926085 The *role* of endogenous interleukin (IL)-18 , IL-12 , IL-1beta , and in the production of [interferon-gamma] induced by Candida albicans in human whole-blood cultures . Positive_regulation IFNG TNF 11943316 928691 The objectives of this study were to determine interleukin (IL)-1 beta , IL-2 , IL-4 , IL-5 , IL-6 , IL-8 , IL-10 , [interferon (IFN)-gamma] and *induction* in bronchoalveolar lavage (BAL) of control horses and horses with heaves both during remission and exacerbation of the disease , and to determine the effect of therapy with inhaled fluticasone propionate on the cytokine profile of horses with heaves . Positive_regulation IFNG TNF 12010985 941365 These findings demonstrate that afferent-phase production is *essential* for the induction of IL-12 and [IFN-gamma] and neutralization of early TNF-alpha results in a T2 shift of the T1/T2 balance of antifungal immunity . Positive_regulation IFNG TNF 12114316 964024 and OSM , only when applied together , *increased* ALP activities and in vitro calcification in HVSMCs in the presence of [IFN-gamma] and 1,25 ( OH ) 2D3 . Positive_regulation IFNG TNF 12115630 964241 Colonic expression of IFN-gamma and was elevated ( 200- and 150-fold , respectively ) and [IFN-gamma] and IL-12 secretion from lymph node cells was *increased* 5,000- and 8-fold , respectively , compared to GpG-ODN treated controls . Positive_regulation IFNG TNF 12233883 988787 [Interferon-gamma (IFN-gamma)] *induced* the cultured salivary gland epithelial cells to express HLA class I antigens , HLA-DR antigens , CD80 , and ICAM-1 , while induced the expression of HLA class I antigens , CD80 , CD86 , and VCAM . Positive_regulation IFNG TNF 12396716 1008692 In both cell lines , increased the expression of PLA(2) IVA and IVC , and [IFN-gamma] *increased* the expression of PLA(2) IIA and IID . Positive_regulation IFNG TNF 12513829 1027774 Viable cells and CFU-C numbers were 31.9 +/- 11.2 and 43 +/- 2.0 respectively , the rate of apoptosis was 42.9 +/- 12.4 in the *presence* of anti-CD95 McAb and or [IFN-gamma] . Positive_regulation IFNG TNF 12670445 1076011 moreover , IL-1 and may also *augment* [IFN-gamma] synthesis . Positive_regulation IFNG TNF 12734353 1087313 *enhances* CD4+ T cell alloproliferation , [IFN-gamma] responses , and intestinal graft-versus-host disease by IL-12 independent mechanisms . Positive_regulation IFNG TNF 12734353 1087317 inhibition *reduced* T cell proliferation and [IFN-gamma] production in supernatants of MLC using either B6 . Positive_regulation IFNG TNF 12734353 1087319 These findings indicate that *promotes* CD4 ( + ) T cell alloproliferation , [IFN-gamma] responses , and intestinal GVHD by IL-12 independent mechanisms . Positive_regulation IFNG TNF 12838506 1108038 T-cell cytotoxicity of human Schwann cells : *promotes* fasL mediated apoptosis and [IFN gamma] perforin mediated lysis . Positive_regulation IFNG TNF 12948914 1137052 We examined the effect of UVA irradiation on the basal and the [IFN-gamma-and] *induced* production of thymus-and activation regulated chemokine ( TARC/CCL17 ) using HaCaT cells . Positive_regulation IFNG TNF 12960156 1158204 Thus [IFNgamma] in the *presence* of GM-CSF and/or differentially regulates monocyte MMPs through induction of TNFalpha and a novel mechanism involving caspase 8 that is independent of apoptosis . Positive_regulation IFNG TNF 1310901 178691 [IFN-gamma] *induced* production in RAW 264.7 cells and this induction was regulated at the transcriptional level . Positive_regulation IFNG TNF 1330686 200203 Our results indicate that [IFN-gamma] *induces* receptors on both myeloid ( e.g. HL-60 ) and epithelial cells ( e.g. HeLa ) . Positive_regulation IFNG TNF 1349767 185995 Taken together we show in this paper that IL-4 decreases [IFN-gamma] but not *induced* up-regulation of ICAM-1 expression on EA.hy 926 cells . Positive_regulation IFNG TNF 13678668 1140184 alone caused robust NO ( 2 ) ( - ) flux , while IL6 had a lesser effect and neither [IFNgamma] nor IL1beta was *active* when applied singly . Positive_regulation IFNG TNF 15149503 1248387 is the main *inducer* of IP-10 by skin fibroblasts , but not [IFN-gamma] or IL-4 . Positive_regulation IFNG TNF 15207784 1261689 The analysis performed during and after PCI revealed that [IFN-gamma] levels increased 15 min after stent implantation in both chronic and ACS patients and that levels *increased* in chronic patients only compared to basal values . Positive_regulation IFNG TNF 15351034 1292532 These results suggested that is involved in pathogenesis of gastritis induced by H. felis infection as IFN-gamma and that an interaction between TNF-alpha and [IFN-gamma] might be *required* in pathogenesis of gastritis induced by Helicobacter infection . Positive_regulation IFNG TNF 1541908 180876 Amo phi s incubated with 10 ( 3 ) ng/ml LPS produced 50 times more TNF than RPm phi s and 5 times more than TGPm phi s , and LPS alone induced maximum TNF production by Am phi s. Stimulated cell supernatant or recombinant [IFN-gamma] alone did not *induce* production . Positive_regulation IFNG TNF 15479886 1319915 IL18 , IL1 beta , and did not *induce* M-CSF , GM-CSF , [IFN gamma] , or OPG production in PHA prestimulated T cells or RA synovial T cells . Positive_regulation IFNG TNF 15604419 1369076 In the presence of [IFN-gamma] , *increased* GTPCH I mRNA in a manner dependent on nuclear factor-kappaB (NF-kappaB) , as this effect was abrogated by overexpression of a dominant negative IkappaB construct . Positive_regulation IFNG TNF 15749890 1379736 In the absence of WSX-1 , an increased production of the proinflammatory cytokines and IL-12p40 *resulted* in elevated CD4+ T cell activation and [IFN-gamma] production , which enhanced macrophage effector functions and reduced bacterial loads . Positive_regulation IFNG TNF 15948973 1421197 Beside its apoptosis inducing capacity in HaCaT cells , rIFN-gamma also induced autocrine [IFN-gamma] production , and combined treatment with IFN-gamma and TNF-alpha *induced* autocrine production . Positive_regulation IFNG TNF 15963988 1428209 More importantly , *induced* LC to produce both [IFN-gamma-inducible-protein] IP-10/CXCL10 , a Th1 attracting chemokine and IL-12 p40 . Positive_regulation IFNG TNF 16279537 1480576 In culture medium with ripe DC the levels of such cytokines as IL-1b , IL-6 , IL-12 , [IFN-gamma] , significantly *increased* and the production of IL-4 decreased . Positive_regulation IFNG TNF 16332515 1503706 RT-PCR analysis revealed external *induced* [IFN-gamma] gene expression in macrophages from tumor environment . Positive_regulation IFNG TNF 16396246 1494541 By using specific cytokine inhibitors we were able to show that endogenous IL-1 , but not IL-18 and was *required* for [IFNgamma] and IL-10 release upon stimulation with A. fumigatus hyphae , whereas conidia induced IFNgamma stimulation is independent of these cytokines . Positive_regulation IFNG TNF 16410312 1513710 Here we show that a mouse lymph node ( LN ) -derived FRC cell line , BLS4 , expresses a transmembrane chemokine , CXC chemokine ligand (CXCL) 16 , in *response* to and [IFNgamma] . Positive_regulation IFNG TNF 16436136 1516393 Either SCF or TNF-alpha could induce release from HMC-1 cells of interleukin (IL)-8 , monocyte chemoattractant protein (MCP)-1 , regulated upon activation normal T-cell expressed and secreted ( RANTES ) , and I-309 , while SCF and *induced* release of macrophage inflammatory protein (MIP)-1beta and [interferon-gamma-inducible] protein-10 (IP-10) , respectively . Positive_regulation IFNG TNF 16544114 1611829 Statistically increased levels of and IL-1beta were detected in the experimental vitreous with maximum levels observed at 12 h . [IFN-gamma] was also *detected* in the experimental vitreous and reached maximum levels at 48 h . Positive_regulation IFNG TNF 16580738 1562456 NPCs ' gelatinase activities of MMP-2 and MMP-9 , as determined by zymography , were *increased* by , and to a lesser extent by [IFN-gamma] . Positive_regulation IFNG TNF 1696166 137207 Both and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , interferon (IFN)-alpha , or [IFN-gamma] . Positive_regulation IFNG TNF 17035338 1674523 It is interesting that we found that [IFN-gamma] *induced* secretion , and the induction of iNOS expression by IFN-gamma was abolished in primary peritoneal macrophages from TNF-alpha-deficient (TNF-alpha-/-) mice or in RAW 264.7 cells treated with anti-TNF-alpha neutralizing antibodies . Positive_regulation IFNG TNF 17045486 1641816 [IFN-gamma] was predominantly *detected* in CD3 ( + ) CD8 ( + ) T cells , whereas IL-2 and were mainly expressed in CD3 ( + ) CD4 ( + ) cells . Positive_regulation IFNG TNF 17068344 1654791 Dibutyryl cAMP and [interferon-gamma] *induce* up-regulation of this receptor on myeloblastic cell lines ( U937 and HL-60 ) , whereas has no effect . Positive_regulation IFNG TNF 17196665 1732434 Meanwhile , 24h after poly I:C injection , expression of TLR3 was markedly elevated within decidua basalis ( DB ) , and endometrial *increased* 2.7-fold but [IFN-gamma] remained unchanged in homogenized endometrium . Positive_regulation IFNG TNF 17266742 1691571 However , LTalpha , but not , was *necessary* for early [IFNgamma] production and the regulation of IFNgamma production later in infection . Positive_regulation IFNG TNF 17484771 1778188 LPS induced production of tumour necrosis factor-alpha (TNF-alpha) , interleukin-6 (IL-6) , IL-10 and [interferon-gamma-inducible] protein-10 (IP-10); SA *induced* , and IL-1beta production ; Positive_regulation IFNG TNF 17709600 1848758 These results suggest that , in the *presence* of , IL-4 and [IFN-gamma] reciprocally regulate tube formation by HMVEC-Ls through autocrine synthesis of CXCR2 and CXCR3 chemokines , respectively . Positive_regulation IFNG TNF 17911406 1803661 MMI decreased cytokine induced CXCL10 secretion by reducing *induced* upregulation of the [IFNgamma] receptor . Positive_regulation IFNG TNF 17928893 1858632 Insights into gene modulation by therapeutic TNF and IFNgamma antibodies : *regulates* [IFNgamma] production by T cells and TNF regulated genes linked to psoriasis transcriptome . Positive_regulation IFNG TNF 17944748 1814248 does *increase* transcription of both [IFN-gamma] and IL-13 in vitro but can also act synergistically with IL-13 in vitro to promote production of RELMbeta , which has also been shown to play a role in resistance to T. muris . Positive_regulation IFNG TNF 1796655 176327 It will focus on interleukin-1 (IL-1) , IL-1 *inhibitors* , , TNF inhibitors , Interleukin-6 (IL-6) , colony stimulating factors (CSF's) , [Interferon-gamma (IFN-gamma)] , growth factors , eicosanoids and prostaglandins , all of which are important in the effector phase of tissue destruction . Positive_regulation IFNG TNF 17994120 1860082 In addition , fludarabine inhibited *stimulated* production of IL-2 and [IFN-gamma] , which play important roles in the onset of GVHD , in Jurkat cells . Positive_regulation IFNG TNF 18239149 1884617 and IFNgamma , mainly when combined , *stimulate* [IFNgamma-inducible] protein of 10 kDa (IP10) and fractalkine production evaluated by ELISA and TaqMan analyses . Positive_regulation IFNG TNF 1829652 161354 Whilst *had* no significant effect on [IFN-gamma] release by NK cells , a 6-hr exposure to IL-2 or PMA stimulated an increase in the amount secreted per single cell . Positive_regulation IFNG TNF 18507686 1958428 In cultured BEC , TNF-alpha , interleukin (IL)-1beta , IL-6 , and [interferon-gamma] *induced* the expression of CDX2 mRNA , though only additionally induced the expression of MUC2 mRNA . Positive_regulation IFNG TNF 18703234 2000459 Importantly , [IFN-gamma] induced NF-kappa B binding to DNA was totally *dependent* on the endogenous released via MEK/ERK signalling pathway . Positive_regulation IFNG TNF 18805021 1987116 A synergistic *role* for IL-1beta and in monocyte derived [IFNgamma] inducing activity . Positive_regulation IFNG TNF 18929641 1994581 Interleukin-1beta , flagellin , [interferon-gamma] , and tumor necrosis factor alpha (TNF-alpha) similarly *induced* Nox1 in a colon cancer cell line ( T84 ) , whereas only fully induced NOXO1 and upregulated superoxide producing activity by ninefold . Positive_regulation IFNG TNF 1902846 156096 On the other hand , plus IFN gamma induced TEC HLA-DR expression on both types of thyroid xenografts at death , although IL-2 alone did not induce HLA-DR expression , and [IFN gamma] *induced* TEC significantly only on normal thyroid xenografts ( but not on Graves ' xenografts ) . Positive_regulation IFNG TNF 1904900 159463 Some of these proteins are *induced* uniquely by [IFN-gamma] , whereas others are also induced by IFN-alpha , , or IL-1 . Positive_regulation IFNG TNF 1918966 168434 *triggers* antitoxoplasmal activity of [IFN-gamma] primed macrophages . Positive_regulation IFNG TNF 19291774 2086831 Both [IFNgamma] and TNFalpha are important in this injury process , but *acts* as an autocrine amplifier of Kupffer cell function , rather than as a direct effector of hepatocellular damage . Positive_regulation IFNG TNF 19472212 2102253 These results suggest that induces CXCL10 production by activating NF-kappaB through ERK and that [IFN-gamma] *induces* CXCL10 production by increasing the activation of STAT1 through JAKs pathways . Positive_regulation IFNG TNF 19501915 2103004 *stimulated* IL-6 , [IFN-gamma] and its own expression more than 3-fold over controls ( P < 0.05 ) . Positive_regulation IFNG TNF 19514423 2092705 Patients with highly active hepatitis and maximal morphological changes in the liver had significant lowering of NDV induced production of IFN-alpha , [IFN-gamma] , TNF-alpha , IL-6 and PGA *induced* production of . Positive_regulation IFNG TNF 19559672 2110578 also *increased* [IFN-gamma] production in NK cells in the presence of IL-15 . Positive_regulation IFNG TNF 19691969 2183054 The results also suggest that expression of [IFN-gamma] is *stimulated* by IL-12p40 and , but not by IFN-alpha . Positive_regulation IFNG TNF 19700144 2133273 Also , the presence of exogenous [IFN-gamma] in the growth medium significantly *induced* IL-6 , but not IL-1beta or , in D1 and D2 cells . Positive_regulation IFNG TNF 19707556 2127265 We recently reported that the IL-1 family cytokines , IL-1beta and IL-18 , strongly *synergize* with for [IFNgamma] production in KG-1 cells , whereas the same cytokines alone have minimal effects on IFNgamma production . Positive_regulation IFNG TNF 19707556 2127272 NFkappaB inhibition resulted in decreased *stimulated* [IFNgamma] release . Positive_regulation IFNG TNF 19879772 2203351 In this study , we demonstrate that in the dendritic precursor-like cell line KG-1 , [IFNgamma] production induced by IL-18 is *potentiated* ( > 5-fold ) by and completely suppressed by TGF-beta1 . Positive_regulation IFNG TNF 19879772 2203355 The mechanism through which *enhances* IL-18 induced [IFNgamma] production is by promoting IL-18 receptor alpha-chain expression which results in higher levels of p38 activation and induces expression of T-bet , a transcriptional regulator of the IFNG gene . Positive_regulation IFNG TNF 20178622 2229057 , though inactive by itself , significantly *augmented* the radiosensitizing activity of [IFN-gamma] . Positive_regulation IFNG TNF 2107144 128708 [IFN-gamma] *induced* the production of and the anti-toxoplasmic effect provided by IFN-gamma seemed to be dependent partly on the production of TNF . Positive_regulation IFNG TNF 2109008 131123 [IFN-gamma] and IL-1 beta alone do not *induce* production , however , the combined treatment of IFN-gamma and IL-1 beta results in a striking synergistic effect on astrocyte TNF-alpha production . Positive_regulation IFNG TNF 2111772 132941 synergistically *enhanced* the antiproliferative activity of [interferon-gamma (IFN-gamma)] in both TNF-sensitive and TNF-resistant variants of the cervical carcinoma line , ME-180 . Positive_regulation IFNG TNF 2117640 139818 Co-infection of macrophages modulates [interferon gamma] and induced *activation* against intracellular pathogens . Positive_regulation IFNG TNF 2129500 150647 In contrast , [interferon-gamma (IFN-gamma)] , which induced major histocompatibility complex ( MHC) class II expression , did not *induce* IL-1 or production . Positive_regulation IFNG TNF 2143488 140004 Although neither IFN-gamma nor alone induce class II molecules on islet cells , synergistic interaction of [IFN-gamma] ( 200 U/ml ) and TNF ( 200 U/ml ) may *induce* class II expression on approximately 50 % of islet cells . Positive_regulation IFNG TNF 22492973 2613139 In late CL cells , and TNF+IFNG+FASL reduced VEGFR2 mRNA , but [TNF+IFNG+FASL] *increased* TSP1 and CD36 mRNA . Positive_regulation IFNG TNF 22526394 2595903 The human colon cell line , HT-29 , increased interleukin (IL)-8 expression in *response* to recombinant human , but not in response to bacterial ligands and [interferon (IFN)-gamma] . Positive_regulation IFNG TNF 2474236 103985 Whereas [IFN-gamma] *induces* secretion of protein , protein secretion of IL-1 by monocytes failed to occur in response to an IFN-gamma stimulus . Positive_regulation IFNG TNF 2497195 109743 significantly *increased* the antiviral activity of [IFN-gamma] , although TNF by itself had no antiviral activity . Positive_regulation IFNG TNF 2826339 81063 On the other hand , only and not retinoic acid was able to *increase* the [IFN-gamma] induced expression of HLA-DR on the cell surface . Positive_regulation IFNG TNF 3026955 66890 In a priori HLA negative cells , a strong *mediated* enhancement of the [Interferon gamma (IFN-gamma)] induced expression of HLA genes was revealed by Northern blot and immunofluorescence analysis . Positive_regulation IFNG TNF 3098851 69070 Our data show that is an important mediator of the cytotoxicity of human monocytes for tumor cells and that [IFN-gamma] can *increase* monocyte cytotoxicity by sensitizing target cells to the lytic action of TNF . Positive_regulation IFNG TNF 7506700 244434 These findings suggest that [interferon gamma] directly *induces* the expression of the inducible nitric oxide synthase gene , whereas and interleukin-1 beta induce it , at least in part , via the induction of intermediary protein ( s ) , and that transforming growth factor-beta 1 inhibits cytokine induced nitric oxide production by blocking the posttranscriptional synthesis of inducible nitric oxide synthase . Positive_regulation IFNG TNF 7545567 318590 [IFN-gamma] stimulation *induced* surface human leukocyte antigen ( HLA ) -DR in both SVRPE and HRPE , while treatment induced surface expression of intercellular adhesion molecule (ICAM)-1 on SVRPE and upregulated ICAM from basal levels on HRPE . Positive_regulation IFNG TNF 7576690 329082 When cells were exposed to a higher number of silica particles , cell activation was attained at shorter times but a substantial number of cells were damaged at 48 h . [Interferon gamma (IFN gamma)] alone *induced* an increased production of in RAW 264.7 cells , not further augmented by a subsequent exposure to silica of the IFN gamma treated cells . Positive_regulation IFNG TNF 7599458 311442 Recombinant , when added to rIL-2 supplemented cultures of LD lymphocytes , *enhanced* the rIL-2 induced generation of [IFN-gamma] in a dose dependent manner . Positive_regulation IFNG TNF 7680009 211340 These results suggest that [IFN gamma] directly *induces* the expression of the iNOS gene whereas mainly induces it via the induction of an intermediary protein in cultured VSMC . Positive_regulation IFNG TNF 7683323 216430 MIF and IFN-gamma synergize with lipid A to mediate migration inhibition but only [IFN-gamma] *induces* production of and nitric oxide . Positive_regulation IFNG TNF 7784700 309913 TNF-alpha , LT , [IFN-gamma] and IL-6 mRNAs were *detected* in patients with active multiple sclerosis , whereas , IL-6 , and endothelin-1 mRNA expression was found frequently in patients with HIV encephalitis . Positive_regulation IFNG TNF 7876546 298762 this means that *induced* [IFN-gamma] does not play a role in mTNF induced lethality . Positive_regulation IFNG TNF 7911785 257850 Further analysis revealed that interleukin 10 (IL-10) inhibited , whereas and IL-12 *enhanced* , [IFN-gamma] production by spleen cells from infected or uninfected mice . Positive_regulation IFNG TNF 7963527 279419 We have previously described two factors , [IFN-gamma enhanced factor X (IFNEX)] and TNF-alpha induced complex X (TIC-X) , whose expression is *induced* by IFN-gamma and , respectively , which interacted with the X box of the DRA promoter . Positive_regulation IFNG TNF 8046224 266987 A single application of 30,000 U nIL-2 *induced* selective and long lasting expression of IL-2 , [IFN-gamma] , and GM-CSF genes , which was not accompanied by accumulation of and IL-6 mRNAs . Positive_regulation IFNG TNF 8097322 217608 We demonstrate that [IFN-gamma] production from SCID splenocytes is *stimulated* by interleukin (IL) 12 , , and IL-2 but is inhibited by IL-10 , IL-10 , IL-12 , and TNF are induced by heat killed Listeria monocytogenes ( hk-LM ) from SCID splenocytes and peritoneal macrophages . Positive_regulation IFNG TNF 8102388 225879 Because and IL-1 are not efficient *inducers* of [IFN-gamma] , the mechanism by which IL-10 inhibits IFN-gamma production is not clear . Positive_regulation IFNG TNF 8136945 251826 With low doses of MLA ( < 5 micrograms ) , [IFN-gamma] induction was *dependent* upon exogenous administered either in advance of or with MLA . Positive_regulation IFNG TNF 8136945 251827 In this case , endogenous TNF-alpha appeared to be a cofactor in the response , since suppression of production with dexamethasone *inhibited* [IFN-gamma] induction , and this inhibition was overcome by administration of exogenous TNF-alpha with MLA . Positive_regulation IFNG TNF 8144873 252538 Stimulation with vaccinia virus constructs encoding IFN-gamma or TNF altered the levels of cytokines produced , in that IFN-gamma expression by stimulator cells led to increased IFN-gamma production , whereas expression by stimulator cells *augmented* both TNF and [IFN-gamma] production by responder cells . Positive_regulation IFNG TNF 8218597 231769 [IFN-gamma] also *induced* increased expression of cell membrane measured by binding of 125I labeled TNF . Positive_regulation IFNG TNF 8218597 231772 These data suggest that [IFN-gamma] selectively *induced* release and expression of 75-kDa . Positive_regulation IFNG TNF 8320887 223168 [IFN-gamma] and IL-beta production by the LAK cells was *enhanced* by stimulation with the Caki-1 , ACHN and K-562 tumor cell lines , while production was stimulated by Caki-1 and K-562 cells . Positive_regulation IFNG TNF 8366291 229321 Cyclosporin A inhibits nitric oxide production by L929 cells in *response* to and [interferon-gamma] . Positive_regulation IFNG TNF 8380280 210137 Porins at 1 microgram/ml induce the greatest release of , IL-1 alpha , and IL-6 by monocytes and of IL-4 by lymphocytes , while porins at 5 micrograms/ml *induce* the greatest release of [IFN-gamma] by lymphocytes . Positive_regulation IFNG TNF 8387619 218051 nIL-1 , [IFN gamma] and TNF alpha could not differentiate between any of the cell lines but IFN gamma and *induced* monocytic surface antigens . Positive_regulation IFNG TNF 8419083 210507 Since it is known that [interferon-gamma (IFN-gamma)] may *induce* the production of , the secretion of this cytokine was examined . Positive_regulation IFNG TNF 8425199 210950 In this cell line , *increases* [IFN-gamma] binding . Positive_regulation IFNG TNF 8432976 212931 Stimulation of human blood monocytes ( adherent mononuclear cells ) and the monocytic cell line , THP-1 , by IL-1 or *leads* to the up-regulation of [IFN-gamma] receptors . Positive_regulation IFNG TNF 8432976 212935 The data suggest that the immunopotentiating effects of IL-1 and are *mediated* in part by enhancing [IFN-gamma] receptor expression on monocytes and macrophages . Positive_regulation IFNG TNF 8445328 213769 N = O synthesis by KC. Treatment with LPS and [IFN-gamma] also *induced* significant production of prostaglandin E2 ( PGE2 ) , thromboxane B2 (TBX2) , , interleukin-1 (IL-1) , and IL-6 . Positive_regulation IFNG TNF 8445328 213775 N = O synthesis by KC. Treatment with LPS and [IFN-gamma] also *induced* significant production of prostaglandin E2 ( PGE2 ) , thromboxane B2 (TBX2) , , interleukin-1 (IL-1) , and IL-6 . Positive_regulation IFNG TNF 8473744 216326 Optimal [IFN-gamma] production was *dependent* on the presence of , inasmuch as addition of antibody to TNF-alpha to spleen cell or NWNA cell cultures significantly reduced IFN-gamma production . Positive_regulation IFNG TNF 8473745 216327 Nevertheless , alone is not *sufficient* to trigger [IFN-gamma] production from purified NK cell populations . Positive_regulation IFNG TNF 8519088 222111 IL-1 and *induced* 6- and 7-fold increases in the synthesis of C3 and factor B . [IFN-gamma] induced increases in the synthesis of all seven proteins , the most pronounced effects being on the synthesis of C4 and C1 inhibitor -- 15- and 44-fold , respectively . Positive_regulation IFNG TNF 8548847 346453 Taken together , these results indicate that the stimulation of [IFN-gamma] production by bacterial DNA is *mediated* by IL-12 and and point to macrophages/monocytes as targets of action of this macromolecule . Positive_regulation IFNG TNF 8700134 375433 NOS induction by was dose dependent from concentrations of 0.06 to 60 nM and was *increased* 2-3-fold by [IFN gamma] . Positive_regulation IFNG TNF 8746784 343504 We demonstrated here that induced binding of NF kappa B p50 and p65 to the NF kappa B-like element of the MHC class I promoter termed region I and [IFN-gamma] *induced* binding of IRF-1 to the adjacent interferon consensus sequence ( ICS ) . Positive_regulation IFNG TNF 8778035 371419 Induction of [IFN-gamma] by IL-12 was *potentiated* by following stimulation of intact spleen cells and purified CD4+ or CD8+ T cells , as well as negatively selected CD4-8- cells from infected B6 mice . Positive_regulation IFNG TNF 8943722 400157 Skin cytokine patterns revealed that in normal mice , interleukin (IL)-2 , [interferon (IFN)-gamma] and mRNA levels *increased* at 12 hr sensitization , whereas these cytokines were below the level of detection in CD4- mice . Positive_regulation IFNG TNF 8997393 404606 Lipopolysaccharides (LPS) , interleukin-1 beta , [interferon-gamma (IFN-gamma)] , and *increase* the levels of Fas mRNA in cultured mesangial and tubular cells . Positive_regulation IFNG TNF 9002955 410529 and IL-6 *enhanced* [IFN-gamma] production , but suppressed IL-4 production in the cultures . Positive_regulation IFNG TNF 9038291 415442 The production of [IFN-gamma] is *induced* by IL-12 with as a costimulator and inhibited by IL-10 . Positive_regulation IFNG TNF 9038291 415449 We suggest that IL-12- and *induced* [IFN-gamma] production may contribute to the natural immunity against microorganisms in the CSF compartment during the acute phase of bacterial meningitis . Positive_regulation IFNG TNF 9178691 434229 ISMCs were analyzed for class II major histocompatibility complex ( MHC ) , intercellular adhesion molecule 1 ( ICAM-1 ) , and B7 before and after exposure to [interferon gamma] ( IFN-gamma ; 100 or 1000 U/ mL ) in the *presence* or absence of IL-1beta ( 10 ng/mL ) or ( 5 ng/mL ) for 72 hours . Positive_regulation IFNG TNF 9213252 441571 C4 secretion was *induced* by [IFN-gamma] , whereas factor B secretion was induced by IL-1 beta , , or IFN-gamma . Positive_regulation IFNG TNF 9285295 451890 At nine months Con A-induced secretion decreased significantly below baseline but [IFN-gamma] secretion *increased* above baseline . Positive_regulation IFNG TNF 9334850 457923 Interestingly , maximal production of [IFN-gamma] by NK cells stimulated with IL-2 plus IFN-alpha/beta was *dependent* on endogenous . Positive_regulation IFNG TNF 9506551 491428 The activation of these pathways , one *activated* by [IFNgamma] and the other by the combination , is independent from myelin antigens and precedes by 2 weeks phases of disease activity ( eg , clinical relapses and/or appearance of gadolinium enhancing lesions on brain magnetic resonance imaging scans during 1 year of follow-up ) . Positive_regulation IFNG TNF 9543699 498244 Blocking of phospholipase D (PLD) derived diacylglycerol ( DAG ) formation by propranolol abrogated IFN-gamma increased HLA class II expression and IL-1 beta secretion , but had little effect on [IFN-gamma] *induced* production . Positive_regulation IFNG TNF 9568729 501355 Bacterial DNA has been shown to induce [IFN-gamma] production in vivo as an indirect *consequence* of interleukin-12 (IL-12) and production from macrophages . Positive_regulation IFNG TNF 9631453 512546 The data suggest that astrocyte derived [IFN-gamma] *induced* by may participate in local immune reactions of the brain in an autocrine and paracrine fashion . Positive_regulation IFNG TNF 9651816 515610 These results indicate that the stimulation of Fas antigen or receptor *increases* Mn-SOD activity of SVHK cells in the presence of [IFN-gamma] and that TPA augments the process through the activation of protein kinase C . Positive_regulation IFNG TNF 9732234 530581 Our results show that 1,000 U/ml [IFN-gamma] *induced* a substantial increase in the expression of both ICAM-1 molecules and HLA-DR on the cell surface , while the effect of on the expression of these molecules was substantially less prominent . Positive_regulation IFNG TNF 9758167 535977 The existence of a synergism between IFN-gamma and TNF-alpha in stimulating IRF-1 expression at the transcriptional level was supported by IRF-1 promoter analysis : [IFN-gamma] directly *induced* the binding of STAT-1 homodimers to the GAS element , while NF-kappaB binding to the kappaB sequence was activated by only after IFN-gamma treatment . Positive_regulation IFNG TNF 9820155 547468 HSV-2 infection and [IFN-gamma] stimulation of macrophages synergistically *induced* secretion and nuclear translocation of NF-kappaB , which bound to a sequence corresponding to a kappaB site in the iNOS promoter . Positive_regulation IFNG TNF 9822292 548723 PHIG greatly reduced the production of IL-12 , interferon-gamma (IFN-gamma) and other cytokines from SPE-A stimulated PBMC , while exogenous IL-12 , but neither IL-1 nor , *restored* [IFN-gamma] production inhibited by PHIG . Positive_regulation IFNG TNF 9825772 549220 VCAM-1 expression on SK-N-SH was *induced* by IL-1alpha and TNF alpha and [IFN gamma] synergized with in this respect on both NB cell lines . Positive_regulation IFNG TNF 9848688 554048 [IFN-gamma] itself also *induced* NO , and IL-6 production from RAW 264.7 cells . Positive_regulation IFNG TNF 9927530 588643 We investigated the *role* of in the regulation of MHC class II antigens and cytokine mRNA expression of TNF , [interferon-gamma (IFN)] , IL-2 , IL-4 , and IL-10 in cardiac allografts to elucidate its immunological mechanism . Positive_regulation IFNG TNFSF10 11466352 839929 Cross linking of by plate bound rTRAIL receptor , death receptor 4-Fc fusion protein *enhanced* T cell proliferation and increased [IFN-gamma] production in conjunction with immobilized suboptimal anti-CD3 stimulation in mouse splenocytes . Positive_regulation IFNG TNFSF10 12615731 1065501 [IFN-gamma] also *induces* expression in NB cell lines . Positive_regulation IFNG TNFSF10 12700648 1082041 Blocking and CD95L significantly *enhance* [IFN-gamma] production in vitro . Positive_regulation IFNG TNFSF10 14872508 1208506 engagement selectively *activated* human CD4 , rather than CD8 , T cells and augmented [IFNgamma] production . Positive_regulation IFNG TNFSF10 15996036 1430138 These findings suggest that upregulation of expression may be *induced* by virus antigen and inflammatory cytokine [IFN-gamma] . Positive_regulation IFNG TNFSF10 16762619 1572177 [Interferon-gamma] and TNF-alpha potently *induced* in IEC . Positive_regulation IFNG TNFSF10 16807984 1580436 In particular , [IFN-gamma] *induced* the highest levels of in cultured astrocytes . Positive_regulation IFNG TNFSF10 18004565 1882802 [IFN-gamma] *induced* expression by DC and LC , and inhibition of TRAIL partially blocked cytotoxic effects . Positive_regulation IFNG TNFSF10 18768829 1957061 Interestingly , TRAIL appears to play a role in tumor recognition by HC/2G-1 in that reactivity was blocked by anti-TRAIL Ab , and soluble could *enhance* [IFN-gamma] secretion by HC/2G-1 in response to renal tumors . Positive_regulation IFNGR2 NR2F1 12093745 960397 Formation of an hER complex *enhances* hER alpha [AF-1] through Ser118 phosphorylation by MAPK . Positive_regulation IFNL1 STAT4 15166220 1273395 Here , we show that activation of this receptor by [IFN-lambda 1] can also inhibit cell proliferation and *induce* phosphorylation , further extending functional similarities with type I IFNs . Positive_regulation IFNL1 TLR7 15699120 1372406 IFN-alpha regulates *dependent* gene expression of IFN-alpha , IFN-beta , IL-28 , and [IL-29] . Positive_regulation IGF1 ALDH2 20731752 2452701 Our data further depicted a likely *role* of Caspase-3 , and AMPK activation in [IGF-1] deficiency induced ` desensitization ' of alcoholic cardiomyopathy . Positive_regulation IGF1 CCND1 1379514 193037 [Insulin-like growth factor 1] by itself does not *induce* expression , and an antisense oligodeoxynucleotide to the insulin-like growth factor 1 receptor RNA does not affect the growth regulated levels of cyclin D1 mRNA . Positive_regulation IGF1 CEACAM6 15208677 1273913 Using inhibitory anti-IGF-IR antibody , a requirement for IGF-IR signaling in the enhanced invasiveness towards [IGF-I] *induced* by overexpression was confirmed . Positive_regulation IGF1 CLU 23051594 2702797 FOXL2 directly stimulates the Clu gene promoter , and we show that PTTG triggers ataxia telangiectasia mutated [kinase/IGF-I/p38MAPK] DNA damage/chromosomal instability signaling , which in turn also *induces* expression . Positive_regulation IGF1 CTGF 14710346 1181247 [IGF-I] *increases* expression of VEGF-A , TGFbeta , and Cyr61 mRNA . Positive_regulation IGF1 CTGF 23555635 2767366 Cartilage-specific over-expression of tissue growth factor ( CCN2/CTGF ) *stimulates* [insulin-like growth factor] expression and bone growth . Positive_regulation IGF1 EPHB2 10347117 616721 Insulin and [IGF-1] *induced* 70-kd S6 kinase phosphorylation in HSC , whereas IGF-1 only induced phosphorylation . Positive_regulation IGF1 EPHB2 10766192 684375 These findings indicate that the antiapoptotic function of [IGF-I] in HT29-D4 cells is based on the enhancement of the survival pathways initiated by TNF , but not Fas , and *mediated* by MAPK/p38 , , and NF-kappaB , which act in concert to suppress the proapoptotic signals . Positive_regulation IGF1 EPHB2 10872812 707121 While the IGF-I induced activation of PKB/Akt was inhibited by PI3-K inhibitor LY294002 but not by MEK inhibitor PD98059 , the *activation* of both MEK and by [IGF-I] was inhibited by both . Positive_regulation IGF1 EPHB2 11517177 851261 To determine whether activation *contributes* to GH-induced [IGF-I] gene expression , hepatocytes were treated for 12 h without or with 50 ng/ml GH and 50 microM PD98059 , an inhibitor of MAPK kinase-1 and -2 . Positive_regulation IGF1 EPHB2 12947030 1157988 and 4 ) [IGF-1] through IGF1R *requires* both and PI3K signaling for proliferation of near-term fetal sheep cardiomyocytes in vitro . Positive_regulation IGF1 EPHB2 15271882 1302452 In this report we provide evidence for the existence in this cell line of a novel mechanism by which [IGF-I] *induces* activation in a manner that is dependent on the basal level of EGFR-TK activity , but is independent of receptor transactivation . Positive_regulation IGF1 EPHB2 15590974 1346135 [IGF-I] potently *induced* activation in proliferating cells , but minimal ERK response was seen in hypertrophic cells . Positive_regulation IGF1 EPHB2 16985260 1673937 In the mitochondria depleted cells , overexpression of HSP60 with adenoviral vector increased the abundance of IGF-I receptor , enhanced IGF-I activated receptor phosphorylation , and augmented [IGF-I] *activation* of Akt and . Positive_regulation IGF1 EPHB2 17303558 1718937 Beta-arrestin and Mdm2 *mediate* [IGF-1] receptor stimulated activation and cell cycle progression . Positive_regulation IGF1 EPHB2 19254730 2072497 [IGF-1] *induced* phosphorylation of , MAP or ERK kinase (MEK)1/2 , and Akt , expression of cyclin D1 , and MC proliferation in cultured human MCs . Positive_regulation IGF1 EPHB2 20371701 2261674 Inhibition of phosphorylation with U0126 [ 1,4-diamino-2,3-dicyano-1,4-bis ( o-aminophenylmercapto ) butadiene ] *blocked* [IGF-I] induction of IGF response element reporter gene activity . Positive_regulation IGF1 EPHB2 21490369 2448474 Growth hormone stimulated [insulin-like growth factor-1] expression in rainbow trout ( Oncorhynchus mykiss ) hepatocytes is *mediated* by , PI3K-AKT , and JAK-STAT . Positive_regulation IGF1 FAS 20356977 2260917 Abundance of was higher in malignant cells than in non-malignant cells , and was *up-regulated* by [IGF1] in both cell types . Positive_regulation IGF1 FOXO1 10358076 618746 Reporter gene studies in HepG2 hepatoma cells show that *stimulates* [insulin-like growth factor] binding protein-1 promoter activity through an IRS , and introduction of IRSs confers this effect on a heterologous promoter . Positive_regulation IGF1 FOXO1 11735247 885716 was able to *transactivate* the [IGF-I-R] promoter in sarcoma derived cell lines , whereas PAX3 exhibited a reduced potency in comparison to the fusion protein . Positive_regulation IGF1 FOXO1 12891709 1117767 However , [IGF-I] did not *induce* phosphorylation of on residues Thr24 and Ser316 . Positive_regulation IGF1 FOXO1 16133873 1450262 [IGF-I] *induced* phosphorylation of Erks ( p42/p44 ) , ( FOXO1a ) ( Ser 253 ) , FKHRL1 ( FOXO3a ) ( Ser 256 ) , and Akt ( Ser 473 ) . Positive_regulation IGF1 FOXO1 18282106 1896454 Long lived daf-2 [insulin/IGF-1] receptor mutants *require* both autophagy and the transcription factor for their longevity , but we find that autophagy takes place in the absence of DAF-16 . Positive_regulation IGF1 FOXO1 21490365 2448470 We found that [IGF-I] *induced* the phosphorylation of and FoxO4 . Positive_regulation IGF1 GLP1R 20621380 2310036 In vitro , *induced* increases in VEGF and [IGF-1] mRNA expression were blunted in cells with PDX-1 siRNA . Positive_regulation IGF1 IGFBP1 10423295 632577 These results suggest that the testicular over-expression of [IGF-I] *induces* increased localization in this tissue . Positive_regulation IGF1 IGFBP1 10596723 573227 Recently , we have shown that [IGF] 's *induce* the secretion of cortisol and 's in adult human adrenocortical cells . Positive_regulation IGF1 IGFBP1 11147791 770290 Human undergoes serine phosphorylation , and this *enhances* both its affinity for [IGF-1] by six- to eightfold and its capacity to inhibit IGF-1 actions . Positive_regulation IGF1 IGFBP1 11994678 939110 Peripheral GH hypersensitivity due to increased GH receptor status , hyperinsulinism and reduced levels likely explain almost normal total IGF-I and *increased* free [IGF-I] levels which , in turn , probably exert an increased negative feedback action on somatotroph cells . Positive_regulation IGF1 IGFBP1 12145180 969722 Posttranslational phosphorylation of significantly *increases* its affinity for [IGF-I] and therefore represents a further mechanism for controlling IGF bioavailability . Positive_regulation IGF1 IGFBP1 1695626 137127 These studies utilized IGF-I analogs that have reduced binding affinity for either the type 1 IGF receptor or binding proteins to study the ligand specificity of and the *role* of IGF-BP-1 in modulating the biological activity of [IGF-I] . Positive_regulation IGF1 IGFBP1 1700662 143337 We conclude that the [IGF-I-like] activity in CM from human breast cancer cell cultures is predominantly *due* to the presence of . Positive_regulation IGF1 IGFBP1 18583428 1946742 Stromal cells were cultured for up to 4 weeks with estradiol ( E ( 2 ) ) and/or medroxy progesterone acetate ( MPA ) in the *presence* or the absence of and , [LR(3)-IGF-I] ( an IGF-I analogue ) that binds to the IGF-I receptor but has reduced affinity for IGFBPs . Positive_regulation IGF1 IGFBP1 23354097 2743146 Our results provide novel demonstration that phosphorylation at S119 can *enhance* affinity for [IGF-I] possibly through stabilization of the IGF-IGFBP-1 complex . Positive_regulation IGF1 IGFBP1 7512318 250295 These results suggested that *regulates* [IGF-I] activity in pregnancy in a similar manner to that in the non-pregnant state . Positive_regulation IGF1 IGFBP1 7538843 287899 This suggested that [IGF] binding to LMH was *due* mainly to membrane bound rather than to type 1 IGF receptors . Positive_regulation IGF1 IGFBP1 7589849 334102 By contrast , [IGF-I] and IGFBP-3 were unaltered by corticosterone in the 30 STZ Ax rats , and *increased* in proportion with the dose of corticosterone . Positive_regulation IGF1 IGFBP1 8958208 401684 We have determined previously that [IGF-I] is *dependent* on the presence of to act as a wound healing agent . Positive_regulation IGF1 IGFBP1 9071988 419843 The decrease in IGFBP-3 and increase in lower molecular weight may have *contributed* to the reduction in serum [IGF-I] by increasing IGF-I clearance from the circulation . Positive_regulation IGF1 IGFBP1 9307161 454440 According to multiple regression analysis free [IGF-I] levels were only *dependent* upon total IGF-I , IGFBP-2 and , whereas IGFBP-3 levels did not contribute to the variance of free IGF-I concentrations in venous cord blood . Positive_regulation IGF1 IGFBP1 9356040 461781 Both human and rat mesangial cells grown on BSA-AGE showed increased IGF-I and total and bioactive TGF-beta medium levels and *enhanced* [IGF-I] , IGF-II , and TGF-beta1 gene expression , compared with cells grown on BSA , whereas total and IGFBP-3 medium content , IGF receptor density and affinity , and IGF-I receptor transcripts were unchanged . Positive_regulation IGF1 IGFBP1 9773839 539465 [IGF] effects are *mediated* by and receptor interactions , hence dietary induced changes in intestinal IGF-II receptor patterns and IGFBP-3 message levels were investigated . Positive_regulation IGF1 IGFBP1 9853082 554844 Elevated levels may *contribute* to a reduced [IGF] activity , especially in dialysed patients . Positive_regulation IGF1 IL1B 1425428 202278 IL-1 alpha and stimulated resorption and *increased* the release of [IGF-I] into the medium during 6 days of culture . Positive_regulation IGF1 IL1B 19834007 2164906 released by stretch is at a low level unable to induce IL-6 but *sufficient* to stimulate [IGF-1] production . Positive_regulation IGF1 IL1B 7510466 249921 *induced* the secretion of [IGF-I] and IGF binding protein in chondrocytes ; Positive_regulation IGF1 IL1B 8780229 380074 Pretreatment of rats with the glucocorticoid receptor antagonist RU-486 prevented the *induced* decrease in plasma and liver IGF-I concentration and the reduction in hepatic [IGF-I] mRNA expression . Positive_regulation IGF1 IRS4 3048247 97185 Whereas remains maximally phosphorylated on tyrosine for up to 60 min in the presence of 100 nM-insulin , [IGF-1] at the same concentration *induces* only a transient response that is maximally 50 % of that observed with insulin . Positive_regulation IGF1 LBP 22500431 2522531 Daily oral ( 60,40,20 mg/kg body weight ) for 30 days significantly recovered uterine atrophy and *restored* serum [IGF-I] level , estrone and progesterone levels that were decreased in elder rats , reduced the expressing of IGFBP-1 in ovarian tissue that were increased in elder rats . Positive_regulation IGF1 MAP2K6 10872812 707127 While the IGF-I induced activation of PKB/Akt was inhibited by PI3-K inhibitor LY294002 but not by MEK inhibitor PD98059 , the *activation* of both and ERK by [IGF-I] was inhibited by both . Positive_regulation IGF1 MAP2K6 12930919 1164062 These effects are mediated through both and PI 3-kinase pathways but not through the [IGF-I] *induction* of TNF-alpha production by the DC . Positive_regulation IGF1 MAP2K6 20642578 2292335 inhibitors and the Raf1 kinase inhibitor significantly *inhibited* [IGF-I] production , and the combination of PD98059 and Raf1 kinase inhibitor showed further inhibition . Positive_regulation IGF1 PGC 23217713 2707903 Rather , it specifically induces [IGF1] and represses myostatin , and expression of in vitro and in vivo *induces* robust skeletal muscle hypertrophy . Positive_regulation IGF1 PLAU 15849510 1399154 [IGF-I] and HGF cooperate to induce migration and invasion of CRC cells , and c-Met and are *required* for IGF-I mediated migration and invasion . Positive_regulation IGF1 PLAU 16140945 1450930 We investigated the hypotheses that ( a ) [insulin-like growth factor-I (IGF-I)-] and hepatocyte growth factor (HGF) mediated migration and invasion of human pancreatic carcinoma cells *require* and uPAR function and ( b ) inhibition of uPAR inhibits tumor growth , retroperitoneal invasion , and hepatic metastasis of human pancreatic carcinomas in mice . Positive_regulation IGF1 PLAU 16140945 1450936 In addition , [IGF-I] and HGF *induced* and uPAR expression in L3.6pl cells . Positive_regulation IGF1 PLAU 16787142 1577467 Herein , the molecular evidence documenting that bone metastasis microenvironment survival factors ( mainly the paracrine growth hormone independent , mediated *increase* of [IGF-1] and the endocrine production of growth hormone dependent IGF-1 , mainly liver derived IGF-1 production ) produce an epigenetic form of prostate cancer cells that are resistant to proapoptotic therapies is reviewed . Positive_regulation IGF1 RARB 10498893 647743 In this study we show that [insulin-like growth factor 1 (IGF-1)] and tetradecanoyl phorbol acetate ( TPA ) *induce* gene expression in neuroblastoma SH-SY5Y cells . Positive_regulation IGF1 SMN2 22669976 2632878 dependent *induction* of CCL2 and [IGF1] mRNAs resulted in increased intracellular levels and secretion of the respective protein products . Positive_regulation IGF1 SPHK1 9395290 468330 In contrast , epidermal growth factor and [insulin-like growth factor-1] , which stimulate proliferation of PC12 cells , *induced* only small and transient increases in activity . Positive_regulation IGF1 TF 8488821 219222 During 6 weeks of IDPN , resulting in an additional 18 +/- 4 kcal and 0.69 +/- 0.03 g of protein/kg body weight per dialysis session , albumin concentration increased to 3.5 +/- 0.14 g/dL ( compared with baseline , P = NS ) , *increased* to 279 +/- 36 mg/dL ( P < 0.002 ) , [IGF-1] increased to 152 +/- 32 ng/mL ( P = NS ) , and PCR increased to 0.81 +/- 0.04 g/kg/d ( P = NS ) . Positive_regulation IGF1 TNF 11889017 920116 *regulates* [insulin-like growth factor-1] and insulin-like growth factor binding protein-3 expression in vascular smooth muscle . Positive_regulation IGF1 TNF 16728464 1612354 Human progenitor cells from bone marrow or adipose tissue produce VEGF , HGF , and [IGF-I] in *response* to by a p38 MAPK dependent mechanism . Positive_regulation IGF1 TNF 16728464 1612360 We hypothesized that *stimulated* progenitor cell secretion of vascular endothelial growth factor ( VEGF ) , hepatocyte growth factor (HGF) , and [insulin-like growth factor I (IGF-I)] by a p38 mitogen activated protein kinase (MAPK) dependent mechanism . Positive_regulation IGF1 TNF 16728464 1612363 Secretion of VEGF , HGF , and [IGF-I] in hMSCs and hAPCs was significantly *increased* by stimulation with and was associated with increased activation of p38 MAPK . Positive_regulation IGF1 TNF 16728464 1612366 The p38 MAPK inhibitor decreased production of *stimulated* VEGF , HGF , and [IGF-I] in hMSCs and hAPCs . Positive_regulation IGF1 TNF 18234850 1876844 , LPS , and hypoxia significantly *increased* human MSC VEGF , FGF2 , HGF , and [IGF-1] production versus controls . Positive_regulation IGF1 TNF 22194466 2549566 Mechanistic investigations in vitro revealed that [IGF-IR] overexpression increased cell survival in the *presence* of high levels of , in a manner associated with increased autocrine production of interleukin-6 (IL)-6 . Positive_regulation IGF1 TNF 22492039 2583488 Furthermore , astrocytes in culture express high levels of FGF-2 in response to IL-1ß , and [IGF-1] in *response* to stimulation . Positive_regulation IGF1 TNF 23677929 2801114 Thereby , IGF-II or *induced* IRA and IGF-I receptor (IGF-IR) overexpression as well as an increase of [IRA/IGF-IR] hybrid receptors in VSMCs . Positive_regulation IGF1 TNF 23677929 2801125 Finally , our data suggest that the IRA isoform and its association with TNF-R1 or [IGF-IR] confers proliferative advantage to VSMCs , mainly in *response* to or IGF-II , which might be of significance in the early atherosclerotic process . Positive_regulation IGF1 TNF 7636260 317445 did not *increase* [IGF-I] synthesis by first inducing PGE2 synthesis , because indomethacin was unable to block the effect of TNF-alpha . Positive_regulation IGF1 TNF 8514850 221965 Furthermore , [IGF-1] induction was *dependent* on endogenous production since IGF-1 protein synthesis was inhibited in the presence of anti-TNF alpha antiserum . Positive_regulation IGF1 TNF 8514850 221967 These results indicate that hyaluronate activation of CD44 induces cytokine expression and macrophage derived [IGF-1] production is *dependent* on expression . Positive_regulation IGF1 TNFSF10 18178561 1875736 At 1 ng/ml , *stimulates* IGF1R mRNA expression greater than [insulin-like growth factor-1] and also activates the IGF1R promoter 7-fold . Positive_regulation IGF1R CTGF 18586434 1935269 Despite being an IGF binding protein , CTGF did not affect IGF1 induced phosphorylation of IGF1 receptor (IGF1R) or IGF1R expression in MAC-T cells , indicating that the attenuating effect of on IGF1 stimulated proliferation of MAC-T cells was not *mediated* by decreasing IGF1 's ability to bind to [IGF1R] or by decreasing IGF1R expression . Positive_regulation IGF1R EPHB2 14657000 1202045 We investigated this crosstalk under different conditions and found that both Akt and activation induced by S1P , but not lysophosphatidic acid (LPA) , in HEY ovarian cancer cells *required* PDGFR but not epidermal growth factor receptor (EGFR) or [insulin-like growth factor-I receptor] ( IGFR ) . Positive_regulation IGF1R EPHB2 18070930 1868050 The PPP induced activation *requires* [IGF-1R] because PPP is not able to induce ERK phosphorylation in IGF-1R negative cells or in cells in which the receptor is knocked down by small interfering RNA . Positive_regulation IGF1R EPHB2 22419550 2606585 Trop-2 could attenuate [IGF-1R] signalling *mediated* AKT/ß-catenin and activation through a direct binding of IGF1 . Positive_regulation IGF1R EPHB2 22871572 2671690 KRAS ( G12D ) - and BRAF ( V600E ) -induced transformation of murine pancreatic epithelial cells requires *stimulated* [IGF1R] signaling . Positive_regulation IGF1R EPHB2 23248036 2757914 Klotho is a tumor suppressor that , through the regulation of [IGF-1R] phosphorylation and subsequent *activation* of downstream Akt-p70S6K and signaling , regulates HCC tumor cell proliferation , apoptosis , autophagy and invasion . Positive_regulation IGF1R FOXO1 24933099 2952252 While Akt and were strongly phosphorylated in copper- and insulin treated cells at all time points studied , only faint tyrosine phosphorylation of [IR/IGF1R] was *detected* in cells exposed to Cu ( II ) by either immunoprecipitation/immunoblot or by immunoblotting using phospho-specific antibodies , whereas insulin triggered strong phosphorylation at these sites . Positive_regulation IGF1R MAP2K6 22871572 2671697 KRAS ( G12D ) - and BRAF ( V600E ) -induced transformation of murine pancreatic epithelial cells requires *stimulated* [IGF1R] signaling . Positive_regulation IGF1R MMP7 21099348 2377290 , produced by colorectal cancer cells , also can *activate* [IGF-1R] by degrading IGFBP-3 and releasing IGF-I . Positive_regulation IGF1R MMP7 21099348 2377291 Our study suggests that concomitant expression of and *activation* of [p-IGF-1R] ( DP ) correlates with poor prognosis in WT KRAS pts treated with anti-EGFR . Positive_regulation IGF1R TNF 12584730 1058773 Histological analysis and immunocytochemical staining confirmed that specifically *increases* IGFBP-3 and IGFBP-4 immunoreactivity , as well as that of the [IGF1R] , in radial glial and Purkinje cells . Positive_regulation IGF1R TNFSF10 18178561 1875735 is *required* for serum-inducible [IGF1R] expression , and antisense IGF1R inhibits TRAIL induced VSMC proliferation . Positive_regulation IGF1R TNFSF10 18178561 1875737 At 1 ng/ml , stimulates IGF1R mRNA expression greater than insulin-like growth factor-1 and also *activates* the [IGF1R] promoter 7-fold . Positive_regulation IGF1R TNFSF10 18178561 1875746 Consistent with this , ammonium pyrrolidine dithiocarbamate , a pharmacological inhibitor of NF-kappaB , blocks *induced* [IGF1R] expression , and p65 overexpression increases IGF1R protein levels . Positive_regulation IGF1R TNFSF10 24161672 2868209 In human gastric cancer MGC803 and BGC823 cells , *induces* [insulin-like growth factor-1 receptor] ( IGF-1R ) pathway activation . Positive_regulation IGF1R TNFSF10 24161672 2868210 The *induced* [IGF-1R] pathway activation is promoted by IGF-1R translocation into lipid rafts . Positive_regulation IGF1R TNFSF10 24161672 2868213 Taken together , *induced* [IGF-1R] activation antagonizes TRAIL induced apoptosis by Cbl-b regulated distribution of IGF-1R in lipid rafts . Positive_regulation IGF2 EPHB2 20371701 2261676 Inhibition of phosphorylation with U0126 [ 1,4-diamino-2,3-dicyano-1,4-bis ( o-aminophenylmercapto ) butadiene ] *blocked* IGF-I induction of [IGF] response element reporter gene activity . Positive_regulation IGF2 FOXO1 20622751 2321773 The expression of [insulin-like growth factor-II] was significantly down-regulated , but the expression of Foxo1 was simultaneously inversely increased , and the translocation of from the cytoplasm to the nucleus was *induced* by rapamycin treatment . Positive_regulation IGF2 IGFBP1 10596723 573234 Recently , we have shown that [IGF] 's *induce* the secretion of cortisol and 's in adult human adrenocortical cells . Positive_regulation IGF2 IGFBP1 1691698 130496 In the IGF-II RRA , purified competed for [ 125I ] IGF-II binding to H-35 cells in a dose dependent manner and , thus , *increased* the apparent value for [IGF-II] in the medium . Positive_regulation IGF2 IGFBP1 2164919 137772 These results indicate that IGF-I and [IGF-II] *induce* an that is different from previously characterized human IGFBPs . Positive_regulation IGF2 IGFBP1 7538843 287906 This suggested that [IGF] binding to LMH was *due* mainly to membrane bound rather than to type 1 IGF receptors . Positive_regulation IGF2 IGFBP1 9356040 461789 Both human and rat mesangial cells grown on BSA-AGE showed increased IGF-I and total and bioactive TGF-beta medium levels and *enhanced* IGF-I , [IGF-II] , and TGF-beta1 gene expression , compared with cells grown on BSA , whereas total and IGFBP-3 medium content , IGF receptor density and affinity , and IGF-I receptor transcripts were unchanged . Positive_regulation IGF2 IGFBP1 9773839 539472 [IGF] effects are *mediated* by and receptor interactions , hence dietary induced changes in intestinal IGF-II receptor patterns and IGFBP-3 message levels were investigated . Positive_regulation IGF2 IGFBP1 9853082 554851 Elevated levels may *contribute* to a reduced [IGF] activity , especially in dialysed patients . Positive_regulation IGF2 SPHK1 22016563 2513604 Phospholipase C and protein kinase C-ß 2 *mediate* [insulin-like growth factor II-dependent] activation . Positive_regulation IGF2 TNF 22194466 2549567 Mechanistic investigations in vitro revealed that [IGF-IR] overexpression increased cell survival in the *presence* of high levels of , in a manner associated with increased autocrine production of interleukin-6 (IL)-6 . Positive_regulation IGF2 TNF 23677929 2801116 Thereby , IGF-II or *induced* IRA and IGF-I receptor (IGF-IR) overexpression as well as an increase of [IRA/IGF-IR] hybrid receptors in VSMCs . Positive_regulation IGF2 TNF 23677929 2801127 Finally , our data suggest that the IRA isoform and its association with TNF-R1 or [IGF-IR] confers proliferative advantage to VSMCs , mainly in *response* to or IGF-II , which might be of significance in the early atherosclerotic process . Positive_regulation IGFBP1 ARG1 21642764 2599078 Our findings also show that *stimulates* [IGFBP-1] despite marked increase in insulin secretion ; Positive_regulation IGFBP1 ARG2 21642764 2599079 Our findings also show that *stimulates* [IGFBP-1] despite marked increase in insulin secretion ; Positive_regulation IGFBP1 BMP2 10950824 723475 Parathyroid hormone decreased , whereas transforming growth factor-beta and , to a lesser extent , *increased* [CTGF/IGFBP-rP2] mRNA levels , but other hormones and growth factors had no effect . Positive_regulation IGFBP1 CGA 7522203 269570 Immunoreactive IGFBP-1 released into the medium was inhibited by both IGF-I and follicle stimulating hormone dose-dependently with an IC50 of 0.14 and 0.13 nM , respectively , while human chorionic *stimulated* [IGFBP-1] release with a 50 % effective dose ( ED50 ) of 0.6 nM . Positive_regulation IGFBP1 CGB8 7522203 269569 Immunoreactive IGFBP-1 released into the medium was inhibited by both IGF-I and follicle stimulating hormone dose-dependently with an IC50 of 0.14 and 0.13 nM , respectively , while human chorionic *stimulated* [IGFBP-1] release with a 50 % effective dose ( ED50 ) of 0.6 nM . Positive_regulation IGFBP1 CRK 17109117 1732106 However this induction ratio was smaller than that of rubratoxin B-induced secretion , suggesting that *regulate* [IGFBP-1] secretion both transcriptionally and post-transcriptionally . Positive_regulation IGFBP1 DES 8536631 346124 Ligand blotting indicated changes in mammary gland secretion of [IGFBP] in *response* to expression . Positive_regulation IGFBP1 ECM1 12960035 1164226 Thus , our data imply that IL-1beta induced MMPs and particularly MMP-3 may up-regulate [IGFBP-1] by disrupting the actin cytoskeleton as a *result* of degradation . Positive_regulation IGFBP1 ECM2 12960035 1164227 Thus , our data imply that IL-1beta induced MMPs and particularly MMP-3 may up-regulate [IGFBP-1] by disrupting the actin cytoskeleton as a *result* of degradation . Positive_regulation IGFBP1 EGF 1379161 192748 However , in the *presence* of ( which was without independent effect on the 30-kDa IGFBP ) , insulin also induced this 30-kDa [IGFBP] . Positive_regulation IGFBP1 EGF 1379198 192788 The *stimulation* of IGF-I and [IGFBP] secretion by appears to be dose dependent with a significant increment already evident at 5 nM . Positive_regulation IGFBP1 EGF 1380055 193137 These results suggest that *regulates* [IGFBP-1] secretion in human granulosa-luteal cells . Positive_regulation IGFBP1 EGF 1703479 151369 Production of this [IGFBP] by Swiss 3T3 cells was *stimulated* by 50-150 % by the mitogens bombesin , vasopressin , platelet derived growth factor , , and 12-O-tetradecanoylphorbol 13-acetate and also by IGF-I . Positive_regulation IGFBP1 EGF 7686479 222146 Although EGF lowered circulating insulin levels , *stimulated* [IGFBP-1] secretion in the presence of exogenously administered insulin . Positive_regulation IGFBP1 EPAS1 16166214 1482700 Transfection experiments demonstrated that especially HIF-3alpha and , and to a lesser extent HIF-1alpha , *contribute* to the induction of [IGFBP-1] mRNA expression in isolated hepatocytes , whereas experiments with vectors for the HIF prolyl hydroxylases (PHD) indicated a major role of PHD-2 in destabilization of HIFs , attenuating the induction of IGFBP-1 under venous pO ( 2 ) . Positive_regulation IGFBP1 FGF1 9757886 535921 The TGF-beta had no apparent effect , and did not consistently *stimulate* [IGFBP-1] secretion . Positive_regulation IGFBP1 FGF10 9757886 535922 The TGF-beta had no apparent effect , and did not consistently *stimulate* [IGFBP-1] secretion . Positive_regulation IGFBP1 FGF11 9757886 535923 The TGF-beta had no apparent effect , and did not consistently *stimulate* [IGFBP-1] secretion . Positive_regulation IGFBP1 FGF12 9757886 535924 The TGF-beta had no apparent effect , and did not consistently *stimulate* [IGFBP-1] secretion . Positive_regulation IGFBP1 FGF13 9757886 535925 The TGF-beta had no apparent effect , and did not consistently *stimulate* [IGFBP-1] secretion . Positive_regulation IGFBP1 FGF14 9757886 535926 The TGF-beta had no apparent effect , and did not consistently *stimulate* [IGFBP-1] secretion . Positive_regulation IGFBP1 FGF16 9757886 535927 The TGF-beta had no apparent effect , and did not consistently *stimulate* [IGFBP-1] secretion . Positive_regulation IGFBP1 FGF17 9757886 535928 The TGF-beta had no apparent effect , and did not consistently *stimulate* [IGFBP-1] secretion . Positive_regulation IGFBP1 FGF18 9757886 535929 The TGF-beta had no apparent effect , and did not consistently *stimulate* [IGFBP-1] secretion . Positive_regulation IGFBP1 FGF19 9757886 535930 The TGF-beta had no apparent effect , and did not consistently *stimulate* [IGFBP-1] secretion . Positive_regulation IGFBP1 FGF2 10737893 679605 Neither growth hormone (GH) , , nor thyroxine ( T ( 4 ) ) *had* any effect on [IGFBP] expression or release . Positive_regulation IGFBP1 FGF2 1385099 200682 While [IGFBP] levels in neuronal cultures were greatly *increased* by , their production by glial cells was inhibited . Positive_regulation IGFBP1 FGF2 7505278 244332 Forskolin and a group of candidate growth factors , including platelet derived growth factor , epidermal growth factor , and acidic and , modestly *increased* [IGFBP] secretion when compared to untreated cells , but these effects were small when compared to IGF-I treatment . Positive_regulation IGFBP1 FGF2 9757886 535931 The TGF-beta had no apparent effect , and did not consistently *stimulate* [IGFBP-1] secretion . Positive_regulation IGFBP1 FGF20 9757886 535932 The TGF-beta had no apparent effect , and did not consistently *stimulate* [IGFBP-1] secretion . Positive_regulation IGFBP1 FGF21 9757886 535933 The TGF-beta had no apparent effect , and did not consistently *stimulate* [IGFBP-1] secretion . Positive_regulation IGFBP1 FGF22 9757886 535934 The TGF-beta had no apparent effect , and did not consistently *stimulate* [IGFBP-1] secretion . Positive_regulation IGFBP1 FGF23 9757886 535935 The TGF-beta had no apparent effect , and did not consistently *stimulate* [IGFBP-1] secretion . Positive_regulation IGFBP1 FGF3 9757886 535936 The TGF-beta had no apparent effect , and did not consistently *stimulate* [IGFBP-1] secretion . Positive_regulation IGFBP1 FGF4 9757886 535937 The TGF-beta had no apparent effect , and did not consistently *stimulate* [IGFBP-1] secretion . Positive_regulation IGFBP1 FGF5 9757886 535938 The TGF-beta had no apparent effect , and did not consistently *stimulate* [IGFBP-1] secretion . Positive_regulation IGFBP1 FGF6 9757886 535939 The TGF-beta had no apparent effect , and did not consistently *stimulate* [IGFBP-1] secretion . Positive_regulation IGFBP1 FGF7 9757886 535940 The TGF-beta had no apparent effect , and did not consistently *stimulate* [IGFBP-1] secretion . Positive_regulation IGFBP1 FGF8 9757886 535941 The TGF-beta had no apparent effect , and did not consistently *stimulate* [IGFBP-1] secretion . Positive_regulation IGFBP1 FGF9 9757886 535942 The TGF-beta had no apparent effect , and did not consistently *stimulate* [IGFBP-1] secretion . Positive_regulation IGFBP1 FOXO1 10385407 625440 When HEP G2 cells were cotransfected with FKHR expression vectors and with IGFBP-1 promoter plasmids containing either native or mutant IREs , expression *induced* a 5-fold increase in activity of the native [IGFBP-1] promoter but no increase in activity of promoter constructs containing insulin unresponsive IRE mutants . Positive_regulation IGFBP1 FOXO1 11733864 885548 All FKHR forms stimulated IGFBP-1 promoter activity , and mutating any of the three FKHR PKB sites impaired the ability of insulin both to inhibit FKHR stimulated [IGFBP-1] promoter activity and to *induce* accumulation in cytoplasm . Positive_regulation IGFBP1 FOXO1 12163409 972366 In HepG2 cells , Hoxa5 has little effect by itself but inhibits the *dependent* activation of the [IGFBP1] promoter . Positive_regulation IGFBP1 FOXO1 15200677 1267933 Subsequent studies in vitro established that [IGFBP-1] is transcriptionally *regulated* by and HOXA10 which together upregulate the IGFBP-1 promoter activity . Positive_regulation IGFBP1 FOXO1 15890677 1445585 In this report , we show that the coactivator p300 directly acetylates lysines in the carboxyl-terminal region of Foxo1 in vivo and in vitro , and potently stimulates *induced* transcription of [IGF binding protein-1] in transient transfection experiments . Positive_regulation IGFBP1 FOXO1 15987820 1452613 Furthermore , in HEC-1B cells , *increased* [IGFBP1] promoter activity , and coexpression of PGRA or PGRB further increased the promoter activity in a cooperative manner . Positive_regulation IGFBP1 GBA 8995239 409362 Insulin suppressed *stimulated* [IGFBP-1] but not IGFBP-4 mRNA levels . Positive_regulation IGFBP1 GCG 16455781 1547957 The expression of [IGF binding protein-1 (IGFBP-1)] is *induced* in rat liver by dexamethasone and and is completely inhibited by 100 nM insulin . Positive_regulation IGFBP1 GCG 1706258 153010 To study the *role* of GH and in the regulation of IGF-I and [IGF-BP] production , we examined IGF-I and IGF-BPs secreted by primary rat hepatocytes cultured in a serum-free medium . Positive_regulation IGFBP1 GCG 1706258 153026 ( 1 x 10 ( -8 ) M ) *stimulated* IGF-I secretion and [IGF-BP] secretion . Positive_regulation IGFBP1 GCG 7521339 243687 Thereafter , blood samples for determination of serum glucose , insulin , insulin-like growth factor binding protein-1 ( IGFBP-1 ) , GH , and insulin-like growth factor-I (IGF-I) concentrations were collected for 180 min . [IGFBP-1] concentrations increased significantly in *response* to , with maximal values observed at 90 min [ in healthy subjects from 36 +/- 6 to 58 +/- 10 micrograms/L ( P < 0.05 ) , in GH-deficient patients from 36 +/- 4 to 54 +/- 6 micrograms/L ( P < 0.001 ) , and in IDDM patients from 115 +/- 18 to 167 +/- 27 micrograms/L ( P < 0.05 ) ] . Positive_regulation IGFBP1 GH1 10737893 679606 Neither , fibroblast growth factor-2 , nor thyroxine ( T ( 4 ) ) *had* any effect on [IGFBP] expression or release . Positive_regulation IGFBP1 GH1 2467308 107788 These findings demonstrate the inhibitory effects of a highly purified porcine serum IGFBP on the biologic effects of IGF-I in vitro , and provide evidence that the *dependent* [IGFBP] blocks the acute insulin-like actions of IGF-I in vivo . Positive_regulation IGFBP1 GPI 22517622 2624731 Expression levels of endometrial GRP , [IGFBP1] , and LGALS15 , whose products stimulate trophectoderm cell migration and attachment , were *increased* by PGE2 , , and IFNT . Positive_regulation IGFBP1 HCG11 10655460 663734 *had* no synergistic effect on SOD and [IGFBP-1] expression . Positive_regulation IGFBP1 HCG14 10655460 663735 *had* no synergistic effect on SOD and [IGFBP-1] expression . Positive_regulation IGFBP1 HCG15 10655460 663736 *had* no synergistic effect on SOD and [IGFBP-1] expression . Positive_regulation IGFBP1 HCG16 10655460 663739 *had* no synergistic effect on SOD and [IGFBP-1] expression . Positive_regulation IGFBP1 HCG17 10655460 663750 *had* no synergistic effect on SOD and [IGFBP-1] expression . Positive_regulation IGFBP1 HCG18 10655460 663749 *had* no synergistic effect on SOD and [IGFBP-1] expression . Positive_regulation IGFBP1 HCG20 10655460 663747 *had* no synergistic effect on SOD and [IGFBP-1] expression . Positive_regulation IGFBP1 HCG21 10655460 663748 *had* no synergistic effect on SOD and [IGFBP-1] expression . Positive_regulation IGFBP1 HCG22 10655460 663745 *had* no synergistic effect on SOD and [IGFBP-1] expression . Positive_regulation IGFBP1 HCG23 10655460 663737 *had* no synergistic effect on SOD and [IGFBP-1] expression . Positive_regulation IGFBP1 HCG24 10655460 663743 *had* no synergistic effect on SOD and [IGFBP-1] expression . Positive_regulation IGFBP1 HCG25 10655460 663738 *had* no synergistic effect on SOD and [IGFBP-1] expression . Positive_regulation IGFBP1 HCG26 10655460 663746 *had* no synergistic effect on SOD and [IGFBP-1] expression . Positive_regulation IGFBP1 HCG27 10655460 663744 *had* no synergistic effect on SOD and [IGFBP-1] expression . Positive_regulation IGFBP1 HCG4 10655460 663740 *had* no synergistic effect on SOD and [IGFBP-1] expression . Positive_regulation IGFBP1 HCG8 10655460 663741 *had* no synergistic effect on SOD and [IGFBP-1] expression . Positive_regulation IGFBP1 HCG9 10655460 663742 *had* no synergistic effect on SOD and [IGFBP-1] expression . Positive_regulation IGFBP1 HIF1A 16428465 1516030 Hypoxia increased the HIF-1 activity , and overexpression or CoCl2 treatment *resulted* in elevated [IGFBP-1] expression in zebra fish embryos . Positive_regulation IGFBP1 HIF3A 16166214 1482699 Transfection experiments demonstrated that especially and HIF-2alpha , and to a lesser extent HIF-1alpha , *contribute* to the induction of [IGFBP-1] mRNA expression in isolated hepatocytes , whereas experiments with vectors for the HIF prolyl hydroxylases (PHD) indicated a major role of PHD-2 in destabilization of HIFs , attenuating the induction of IGFBP-1 under venous pO ( 2 ) . Positive_regulation IGFBP1 HMGA1 22745191 2659702 Using chromatin immunoprecipitation combined with protein-protein interaction studies of nuclear proteins in vivo , and transient transcription assays in living cells , we show that is *required* for gene activation of the [IGF binding proteins 1 (IGFBP1)] and 3 ( IGFBP3 ) , two major members of the IGF binding protein superfamily . Positive_regulation IGFBP1 HNF1A 7684229 216617 To test whether *activates* [IGFBP-1] transcription , HEP G2 cells and HeLa cells were cotransfected transiently with HNF1 expression vectors and with IGFBP-1 promoter/chloramphenicol acetyltransferase reporter gene constructs . Positive_regulation IGFBP1 HNF1A 7684229 216618 *increased* [IGFBP-1] promoter activity in both HEP G2 and HeLa cells . Positive_regulation IGFBP1 HOXA10 15200677 1267934 Subsequent studies in vitro established that [IGFBP-1] is transcriptionally *regulated* by FOXO1 and which together upregulate the IGFBP-1 promoter activity . Positive_regulation IGFBP1 HOXA10 17350963 1727205 The functional *role* of in [IGFBP1] expression was further explored using human endometrial stromal cells (HSC) . Positive_regulation IGFBP1 IGF1 10423295 632584 These results suggest that the testicular over-expression of *induces* increased [IGFBP] localization in this tissue . Positive_regulation IGFBP1 IGF1 10474130 642350 Clinical studies suggest that circulating concentrations of insulin-like growth factor binding protein-3 ( IGFBP-3 ) are decreased or unaffected by IGF-I administration , whereas acute increases in may *increase* serum [IGFBP-1] . Positive_regulation IGFBP1 IGF1 10596723 573241 Recently , we have shown that 's *induce* the secretion of cortisol and [IGF-BP] 's in adult human adrenocortical cells . Positive_regulation IGFBP1 IGF1 10801263 691438 Antagonists of the IGF-I receptor , IGF-I Analog or monoclonal antibody 1H7 , elicited concentration dependent inhibition of growth and decrease in IGFBP-3 , IGFBP-4 , and IGFBP-5 production , implying that endogenous *stimulated* growth and [IGFBP] production . Positive_regulation IGFBP1 IGF1 1281161 205618 Unlike cell associated IGFBP-30K , secretion of [IGFBP] was *stimulated* ( 6.8 +/- 0.5-fold , n = 2 ) by , whereas IGFBP secretion was inhibited 54 % by insulin . Positive_regulation IGFBP1 IGF1 1377704 190521 In addition , markedly *increased* levels of the 29/32/34 kDa [IGFBP] triplet in U-2 cells , but had little or no effect in the other human and rat osteosarcoma cell lines . Positive_regulation IGFBP1 IGF1 1381377 196069 A significant correlation was found between the increase in E2 and inhibition of [IGFBP-1] secretion in *response* to . Positive_regulation IGFBP1 IGF1 1711459 161050 The decrease in peptide and *induction* of [IGFBP-1] and -2 may provide protective mechanisms by inhibiting growth during malnutrition . Positive_regulation IGFBP1 IGF1 1723834 175425 Subcutaneous injection of IGF-I , 40 micrograms/kg , provoked an increase in serum IGF-I levels to close to the lower limits of the normal range and a small increase in IGFBP-3 , suggesting that IGF-I has a direct effect on the synthesis of this *dependent* [IGFBP] . Positive_regulation IGFBP1 IGF1 7525256 276883 The presence of a larger isoform of IGFBP-2 in a differentiation dependent manner and a potentially novel [IGFBP] in *response* to suggests that these IGFBPs may be important in modulating IGF-I action in adipogenesis . Positive_regulation IGFBP1 IGF1 7589849 334103 By contrast , and IGFBP-3 were unaltered by corticosterone in the 30 STZ Ax rats , and [IGFBP-1] *increased* in proportion with the dose of corticosterone . Positive_regulation IGFBP1 IGF1 7684393 217570 These data indicate that [IGFBP-1] and E2 are differentially *regulated* by in the human ovary . Positive_regulation IGFBP1 IGF1 7687577 222459 Equimolar levels of or insulin *stimulated* [IGFBP] release , however , at levels lower than that induced by IGF-II . Positive_regulation IGFBP1 IGF1 8056933 268037 In control animals , a striking *increase* ( 143 % ) in the predominant 39-45 kDa serum [IGFBP] ( BP-3 ) , with little change in serum , accompanied the marked deceleration of growth which occurred between 2 and 8 months ; the levels of IGF-I and its BPs declined by 15 % and 34 % , respectively , later in life . Positive_regulation IGFBP1 IGF1 8691111 372679 Since may *regulate* [IGFBP] production , the effect of IGF-I on IGFBPs expressed by TC-1 cells was determined . Positive_regulation IGFBP1 IGF1 9141538 428423 P < 0.01 ) , but not young , men , indicating that low GH secretion and/or production may *contribute* to the elevation of [IGFBP-1] levels in aging . Positive_regulation IGFBP1 IGF1 9462691 485202 [IGFBP] secretion by L6 cells is *stimulated* by both and cAMP dependent pathways , whereas IGFBP-5 secretion by BC3H-1 cells is stimulated only by the insulin/IGF pathway . Positive_regulation IGFBP1 IGF1 9654167 516106 alone *resulted* in a significant dose dependent increase in medium estradiol ( E2 ) ( p < 0.05 ) and progesterone ( P ) ( p < 0.001 ) and suppression of [IGF binding protein-1 (IGFBP-1)] ( p < 0.001 ) , without any increase in [ 3H ] -thymidine incorporation ( P=0.10 ) . Positive_regulation IGFBP1 IGF1 9814485 546353 To better understand how estradiol and IGF-I affect the IGF-I axis , a series of three studies was conducted to examine how estradiol and GH interact to affect the IGF-I axis and how *regulates* [IGFBP-1] and -3 during GH inhibition or receptor antagonism in adult female rhesus monkeys . Positive_regulation IGFBP1 IGF1R 7540432 310044 After ARF renal mRNA for IGF-1 was decreased , was unchanged and [IGFBP-1] was *increased* . Positive_regulation IGFBP1 IGF2 10596723 573242 Recently , we have shown that 's *induce* the secretion of cortisol and [IGF-BP] 's in adult human adrenocortical cells . Positive_regulation IGFBP1 IGF2 1711459 161051 The decrease in peptide and *induction* of [IGFBP-1] and -2 may provide protective mechanisms by inhibiting growth during malnutrition . Positive_regulation IGFBP1 IGF2 2164919 137779 These results indicate that IGF-I and *induce* an [IGFBP] that is different from previously characterized human IGFBPs . Positive_regulation IGFBP1 IGF2 7505466 237662 In contrast , [ Leu-27 ] , which interacts with the type II but not type I IGF receptor , *had* no effect on [IGFBP-1] protein levels or promoter activity . Positive_regulation IGFBP1 IGFBP1 15692833 1376311 Decreased renal filtration and increased hepatic production of and -2 both *contribute* to high levels of serum [IGFBP] . Positive_regulation IGFBP1 IGFBP2 12933651 1132567 IGF-I and IGF binding protein 3 (IGFBP-3) levels were significantly reduced , but by different degrees , in both mouse lines , but [IGFBP-1] and -4 levels were reduced and levels *increased* in GHR -/- mice but unaltered in GHA mice . Positive_regulation IGFBP1 IGFBP2 15692833 1376312 Decreased renal filtration and increased hepatic production of both *contribute* to high levels of serum [IGFBP] . Positive_regulation IGFBP1 IGFBP3 10470776 641399 The carrier protein increased from 126 to 283 mg/L at the end of the study period , and the inhibiting [IGF-BP1] decreased initially from 19 to 14 mg/L and then increased until the end of the study to 31 mg/L. Nitrogen balance *increased* initially from 4.6 to 13.6 g/24 hrs and thereafter decreased until the end of rHGH treatment to 8.3 g/24 hrs . Positive_regulation IGFBP1 IGFBP3 15549410 1374883 In general , [IGFBP-1] , -2 , -4 , and -6 inhibit and and -5 *stimulate* osteoblast function . Positive_regulation IGFBP1 IGFBP3 1719017 169485 With advancing age and pubertal status , [IGFBP-1] declined and *increased* significantly in the control , but not the diabetic group . Positive_regulation IGFBP1 IGFBP3 7549102 327103 Secretion of [IGFBP-1] was *increased* by Bu2cAMP in the medium , that of by IGF-I , and that of IGFBP-4 by both IGF-I and Bu2cAMP . Positive_regulation IGFBP1 IGFBP3 7589849 334104 By contrast , IGF-I and were unaltered by corticosterone in the 30 STZ Ax rats , and [IGFBP-1] *increased* in proportion with the dose of corticosterone . Positive_regulation IGFBP1 IGFBP3 8781981 380409 When conditioned media from skin , liver , lung and kidney explants were analyzed , phosphorylated [IGFBP-1] was only *detected* in liver samples whereas was found in all media . Positive_regulation IGFBP1 IGFBP3 9124573 424034 Both peptides enhanced expression of [IGF binding proteins (IGFBP) 1] and 2 and *induced* in the older rats . Positive_regulation IGFBP1 IGFBP4 12376561 996890 Cell attachment to a general ECM gel was unaffected by [IGFBP-1] and -6 but was significantly *increased* by and -5 and decreased by IGFBP-2 and -3 . Positive_regulation IGFBP1 IGFBP4 7549102 327104 Secretion of [IGFBP-1] was *increased* by Bu2cAMP in the medium , that of IGFBP-3 by IGF-I , and that of by both IGF-I and Bu2cAMP . Positive_regulation IGFBP1 IGFBP5 11344214 814141 Both glycosylated and nonglycosylated IGFBP-3 bound to FN with a K ( d ) of approximately 0.3 nmol/L . IGF-I and [IGFBP-1] had no effect on IGFBP-3 binding to FN. Competitive inhibition of IGFBP-3 binding to FN was observed in the *presence* of and heparin . Positive_regulation IGFBP1 IGFBP5 12376561 996891 Cell attachment to a general ECM gel was unaffected by [IGFBP-1] and -6 but was significantly *increased* by and decreased by IGFBP-2 and -3 . Positive_regulation IGFBP1 IGFBP5 15549410 1374884 In general , [IGFBP-1] , -2 , -4 , and -6 inhibit and *stimulate* osteoblast function . Positive_regulation IGFBP1 IL1A 10070049 594264 Finally , preincubating cells with pyrrolidinedithiocarbamate ( PDTC ) but not SN50 ( inhibitors of nuclear factor-kappaB activation and nuclear translocation , respectively ) attenuated increases in [IGFBP-1] *induced* by . Positive_regulation IGFBP1 IL1B 10965886 728056 The ability of to *stimulate* the expression of [IGFBP-1] and the phosphorylation of the above kinases was specifically inhibited by PD98059 , a MEK-1 inhibitor . Positive_regulation IGFBP1 IL1B 10965886 728063 Conversely , a PKA inhibitor ( H-89 ) inhibited the ability of cAMP , but not to *stimulate* [IGFBP-1] synthesis . Positive_regulation IGFBP1 IL1B 11108281 756836 Both dbcAMP and , in the presence of hormones , can independently *induce* [IGFBP-1] gene expression and decidualization . Positive_regulation IGFBP1 IL1B 12062820 953284 In addition , as a possible conceptus mediated factor , can *induce* [IGFBP-1] expression in the presence of hormones following 3 days of incubation . Positive_regulation IGFBP1 IL1B 12062820 953286 Inhibition of induced pathways *leads* to reduction of [IGFBP-1] expression , suggesting that IL-1beta may be involved in the events leading to decidualization in baboons . Positive_regulation IGFBP1 IL1B 12960035 1164224 We reported that ( 10 ng/ml ) with steroid hormones [ 36 nm estradiol-17beta , 1 microm medroxyprogesterone acetate ( P ) , and 100 ng/ml relaxin ] *induces* in vitro [IGFBP-1] synthesis . Positive_regulation IGFBP1 IL1B 17645865 1775766 Employment of c-Jun N-terminal kinase (JNK) inhibitor SP600125 resulted in 3-fold reduction of IGFBP-1 mRNA and protein levels , indicating that *induced* [IGFBP-1] production is mediated through JNK activation . Positive_regulation IGFBP1 IL1B 17645865 1775767 Moreover , glutathione depletion in hepatocytes from young rats potently activated JNK , as well as increased *induced* [IGFBP-1] mRNA levels , suggesting that age related oxidative stress underlies the upregulated JNK activation and IGFBP-1 expression . Positive_regulation IGFBP1 IL6 22104117 2529702 In vitro studies showed that IL-1ß , and TNFa *stimulated* [IGFBP-1] mRNA expression in SMCs . Positive_regulation IGFBP1 IL6 22198242 2563579 In adjusted mixed linear models , decreasing BMI was significantly associated with lower levels of soluble E-selectin and and *increases* in GH , adiponectin , and [IGFBP-1] . Positive_regulation IGFBP1 IL6 8920958 396653 Moreover , produced dose- and time dependent *increases* in [IGFBP-1] production by HepG2 cells . Positive_regulation IGFBP1 IL6 8920958 396654 The maximal *induced* increase in [IGFBP-1] was comparable to that observed with dexamethasone , and this increase was attenuated by diltiazem or dantrolene , both of which are known to reduce the cytosolic Ca2+ concentration . Positive_regulation IGFBP1 INHBA 9435438 482556 similarly *promotes* [IGFBP] accumulation , but it does not promote apoptosis . Positive_regulation IGFBP1 INS 10973497 730946 negatively *regulates* expression of the insulin-like growth factor binding protein 1 ( [IGFBP-1] ) gene by means of an insulin-responsive element (IRE) that also contributes to glucocorticoid stimulation of this gene . Positive_regulation IGFBP1 INS 11344207 814137 *inhibition* of endometrial stromal cell tissue inhibitor of metalloproteinase-3 and [IGF binding protein-1] suggests paracrine interactions at the decidua : trophoblast interface during human implantation . Positive_regulation IGFBP1 INS 12176668 977198 Since [IGFBP-1] is acutely *regulated* by , this could have important consequences in hyperinsulinaemic and insulin-resistant states . Positive_regulation IGFBP1 INS 1379161 192741 IGF-I , IGF-II , and the IGF-I analogs , but not , also *induced* production of an unidentified 30-kDa [IGFBP] not normally detectable in these cultures . Positive_regulation IGFBP1 INS 1379161 192749 However , in the presence of epidermal growth factor ( which was without independent effect on the 30-kDa IGFBP ) , also *induced* this 30-kDa [IGFBP] . Positive_regulation IGFBP1 INS 1383070 198357 Since insulin-like growth factor I (IGF-I) has been shown to stimulate nerve regeneration , and [IGF binding protein-1] is acutely *regulated* by plasma we have investigated the relationships between plasma IGF-I , IGFBP-1 , glucose and insulin in Type 1 ( insulin dependent ) diabetic patients with peripheral polyneuropathy . Positive_regulation IGFBP1 INS 1384818 200659 These results show that the gene expression of IGF-I and [IGFBP-1] is differently *regulated* by glucocorticoids and in primary cultures of rat hepatocytes . Positive_regulation IGFBP1 INS 1385468 200774 Since insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) are believed to be involved in endometrial differentiation , and *regulates* [IGFBP] production in a variety of cells , we have investigated the modulatory roles of EGF , progesterone , and insulin on IGFBP secretion by long term cultures of human endometrial stromal cells . Positive_regulation IGFBP1 INS 1385468 200790 In the nondecidualized state , *increased* the secretion of IGFBP-3 , IGFBP-2 , and the 24-kDa [IGFBP] , which were slightly inhibited by EGF and relatively unaffected by progesterone alone . Positive_regulation IGFBP1 INS 15496506 1359585 These data suggest that the xenobiotic-hormonal regulatory region of the IGFBP-1 promoter mediates an up-regulation of [IGFBP-1] expression by TCDD even in the *presence* of . Positive_regulation IGFBP1 INS 16002526 1452879 These studies indicate that glucocorticoids and IRS associated factors function together to mediate effects of insulin and glucocorticoids on promoter activity and that glucocorticoid treatment creates a complex environment in which *regulates* [IGFBP-1] expression through both IRS dependent and IRS independent mechanisms . Positive_regulation IGFBP1 INS 16200845 1463861 On the other hand , both and leptin *cause* decreased levels of [IGFBP-1] in girls with PA , even if they are lean . Positive_regulation IGFBP1 INS 16801575 1579402 [IGF binding protein (IGFBP)-1] is negatively *regulated* by . Positive_regulation IGFBP1 INS 1698676 141602 Previous studies showed that levels of [IGFBP-1] are *regulated* by . Positive_regulation IGFBP1 INS 17088407 1644080 inhibits and glucocorticoids *stimulate* hepatocyte [IGFBP-1] gene expression and production . Positive_regulation IGFBP1 INS 17088407 1644082 This study suggests that the major inhibitory *role* of in the regulation of liver [IGFBP-1] production in mammals is not found in salmon . Positive_regulation IGFBP1 INS 1710998 158292 The production was inhibited by clomiphene and progesterone , whereas estrogen , cortisol and *had* no effect on [IGFBP-1] secretion . Positive_regulation IGFBP1 INS 18234122 1871292 differentially *regulates* endometrial [IGFBP-1] and IGFBP-2 secretion in the baboon . Positive_regulation IGFBP1 INS 2475566 116895 IGF-I and -II were approximately equipotent with a fourfold increase in IGF-BP release at 19.7 nmol/l . *caused* a release of [IGF-BP] and IGF-I and -II from fibroblasts at supraphysiological concentrations ( 16.7 nmol/l ) which again was maximal on sparse cell cultures . Positive_regulation IGFBP1 INS 2542098 112193 The authors evaluated the *role* of in the regulation of serum levels of 34K [IGF-BP] in patients with polycystic ovarian disease ( PCOD ) . Positive_regulation IGFBP1 INS 7505463 237655 These data indicate that endometrial stromal cell [IGFBP-1] is *regulated* by , at concentrations that are compatible with insulin acting via its own receptor , while the effects of IGF-I and IGF-II on IGFBP-1 secretion , are suggestive of their acting probably through the type I IGF receptor . Positive_regulation IGFBP1 INS 7513781 253905 We studied basal and *stimulated* serum levels of IGF-I and -II and [IGFBP-1] , -2 , and -3 in six acromegalic patients before and 2 months after successful adenomectomy compared with a group of sex- and age matched healthy , untreated subjects . Positive_regulation IGFBP1 INS 7514335 241715 Hepatic expression of [IGFBP-1] is *regulated* at the level of gene transcription by in a dominant negative fashion , while glucocorticoids and cAMP analogues exert positive effects on hepatocellular IGFBP-1 mRNA . Positive_regulation IGFBP1 INS 7537614 300936 These data suggest that strongly *regulates* pre- and post-translational renal [IGF BP1] gene expression and implicate BP1 as an important determinant of IGF-I activity in diabetic kidney . Positive_regulation IGFBP1 INS 7686479 222147 Although EGF lowered circulating insulin levels , EGF stimulated [IGFBP-1] secretion in the *presence* of exogenously administered . Positive_regulation IGFBP1 INS 7686479 222148 Thus , the increase in [IGFBP-1] did not appear to be *mediated* by changes in serum . Positive_regulation IGFBP1 INS 7687525 222451 In-vitro studies have shown that both and glucose independently *regulate* [IGFBP-1] secretion in an inverse manner . Positive_regulation IGFBP1 INS 7687577 222460 Equimolar levels of IGF-I or *stimulated* [IGFBP] release , however , at levels lower than that induced by IGF-II . Positive_regulation IGFBP1 INS 9420884 345300 Octreotide treatment also did not change serum IGF-I levels in either group , but serum levels decreased significantly and [IGFBP-1] levels *increased* significantly in both groups ; Positive_regulation IGFBP1 INS 9462691 485203 [IGFBP] secretion by L6 cells is *stimulated* by both and cAMP dependent pathways , whereas IGFBP-5 secretion by BC3H-1 cells is stimulated only by the insulin/IGF pathway . Positive_regulation IGFBP1 INS 9814485 546360 Although overall serum concentrations of IGFBP-1 are elevated by estradiol and may be differentially affected by IGF-I treatment , acute changes in [IGFBP-1] are more a *consequence* of changes in serum in response to food intake . Positive_regulation IGFBP1 INTS2 21051252 2349350 The fasting mean levels of [IGFBP-1] were *increased* in both T1D with normal renal function ( geometric mean : 216 µg/l , range 169-275 µg/l ) and with CKD5D ( geometric mean : 112 µg/l , range 78-162 µg/l , p=0.15 compared with T1D patients ) in spite of a high mean insulin level ( 32±5 mU/l ) . Positive_regulation IGFBP1 LEFTY1 20056823 2211950 Overexpression of in decidualized HuF cells with an adenovirus that transduced LEFTY caused a marked decrease in IGFBP1 secretion , and withdrawal of medroxyprogesterone acetate from decidualized cells *resulted* in a decrease in [IGFBP1] secretion and an increase in LEFTY expression . Positive_regulation IGFBP1 LEFTY2 20056823 2211949 Overexpression of in decidualized HuF cells with an adenovirus that transduced LEFTY caused a marked decrease in IGFBP1 secretion , and withdrawal of medroxyprogesterone acetate from decidualized cells *resulted* in a decrease in [IGFBP1] secretion and an increase in LEFTY expression . Positive_regulation IGFBP1 LEP 16200845 1463862 On the other hand , both insulin and *cause* decreased levels of [IGFBP-1] in girls with PA , even if they are lean . Positive_regulation IGFBP1 MSC 16499939 1581826 also *enhanced* the [IGFBP-1] gene expression in a dose dependent manner . Positive_regulation IGFBP1 NOS2 23790320 2824224 Both cyclooxygenase-2 and *mediated* LPA effect on [IGFBP-1] and IL-10 expression . Positive_regulation IGFBP1 NOS3 22357965 2572185 [hIGFBP1] *induced* vasodilatation independently of IGF and increased activity in arterial segments ex vivo , while in endothelial cells , hIGFBP1 increased eNOS Ser ( 1177 ) phosphorylation via phosphatidylinositol 3-kinase signaling . Positive_regulation IGFBP1 PGR 10459849 639623 The purpose of this study is to investigate whether directly *activates* the [IGFBP-1] gene promoter . Positive_regulation IGFBP1 PGR 15987820 1452611 In the present study , we investigated the *role* of two transcription factors , and a member of the forkhead box class O family of transcription factors ( FOXO1A ) , in the regulation of the [IGFBP1] gene in endometrial cells . Positive_regulation IGFBP1 PI3 17032741 1630815 In contrast , the activation of is *required* for insulin regulation of [IGFBP1] under all conditions tested . Positive_regulation IGFBP1 PLD1 17065600 1683947 Moreover , knockdown of PLD1 by siRNA and blockage of PLD by treatment with 0.3 % 1-butanol decreased PRL/IGFBP1 mRNA expression , whereas overexpression *increased* [PRL/IGFBP1] mRNA expression . Positive_regulation IGFBP1 PLG 10750042 681357 Finally , cell treatment with plasminogen (PLG) markedly enhanced neuroblast migration ( by over 200 % , P < 0.01 ) , whereas incubation with the PLG inhibitor 4- ( 2-aminoethyl ) -benzenesulphonyl fluoride reduced cell motility ( by 80 % , P < 0.01 ) , thus suggesting an involvement of *dependent* [IGFBP] proteolysis in the regulation of neuroblast motility . Positive_regulation IGFBP1 PRKAA1 11302732 803415 The *role* of , an important signaling system in lipid and carbohydrate metabolism , in regulating [IGFBP-1] was studied in H4-II-E rat hepatoma cells . Positive_regulation IGFBP1 PRKAA1 15236799 1269753 can also directly *stimulate* [IGFBP-1] synthesis in hepatocytes , and interfere with the ras/raf/erk pathway of IGF-I signaling . Positive_regulation IGFBP1 PRKAA2 11302732 803416 The *role* of , an important signaling system in lipid and carbohydrate metabolism , in regulating [IGFBP-1] was studied in H4-II-E rat hepatoma cells . Positive_regulation IGFBP1 PRKAA2 15236799 1269754 can also directly *stimulate* [IGFBP-1] synthesis in hepatocytes , and interfere with the ras/raf/erk pathway of IGF-I signaling . Positive_regulation IGFBP1 PRKAB1 11302732 803417 The *role* of , an important signaling system in lipid and carbohydrate metabolism , in regulating [IGFBP-1] was studied in H4-II-E rat hepatoma cells . Positive_regulation IGFBP1 PRKAB1 15236799 1269755 can also directly *stimulate* [IGFBP-1] synthesis in hepatocytes , and interfere with the ras/raf/erk pathway of IGF-I signaling . Positive_regulation IGFBP1 PRKAB2 11302732 803418 The *role* of , an important signaling system in lipid and carbohydrate metabolism , in regulating [IGFBP-1] was studied in H4-II-E rat hepatoma cells . Positive_regulation IGFBP1 PRKAB2 15236799 1269756 can also directly *stimulate* [IGFBP-1] synthesis in hepatocytes , and interfere with the ras/raf/erk pathway of IGF-I signaling . Positive_regulation IGFBP1 PRKACB 15722441 1389603 RLX enhanced [IGFBP-1] promoter activity was *inhibited* by cAMP dependent inhibitor , H-89 . Positive_regulation IGFBP1 PRKACB 7683658 216542 In addition , cotransfection of the catalytic subunit of cAMP dependent protein kinase A (PKA) with the native 1205-bp IGFBP-1 promoter construct stimulated IGFBP-1 promoter activity 3.9-fold , but the TAGCA mutation decreased by 73 % the ability of to *stimulate* [IGFBP-1] promoter activity above control levels . Positive_regulation IGFBP1 PRKACG 15722441 1389604 RLX enhanced [IGFBP-1] promoter activity was *inhibited* by cAMP dependent inhibitor , H-89 . Positive_regulation IGFBP1 PRKACG 7683658 216543 In addition , cotransfection of the catalytic subunit of cAMP dependent protein kinase A (PKA) with the native 1205-bp IGFBP-1 promoter construct stimulated IGFBP-1 promoter activity 3.9-fold , but the TAGCA mutation decreased by 73 % the ability of to *stimulate* [IGFBP-1] promoter activity above control levels . Positive_regulation IGFBP1 PRKAG1 11302732 803419 The *role* of , an important signaling system in lipid and carbohydrate metabolism , in regulating [IGFBP-1] was studied in H4-II-E rat hepatoma cells . Positive_regulation IGFBP1 PRKAG1 15236799 1269757 can also directly *stimulate* [IGFBP-1] synthesis in hepatocytes , and interfere with the ras/raf/erk pathway of IGF-I signaling . Positive_regulation IGFBP1 PRKAG2 11302732 803420 The *role* of , an important signaling system in lipid and carbohydrate metabolism , in regulating [IGFBP-1] was studied in H4-II-E rat hepatoma cells . Positive_regulation IGFBP1 PRKAG2 15236799 1269758 can also directly *stimulate* [IGFBP-1] synthesis in hepatocytes , and interfere with the ras/raf/erk pathway of IGF-I signaling . Positive_regulation IGFBP1 PRKAR1A 15722441 1389605 RLX enhanced [IGFBP-1] promoter activity was *inhibited* by cAMP dependent inhibitor , H-89 . Positive_regulation IGFBP1 PRKAR1A 7683658 216544 In addition , cotransfection of the catalytic subunit of cAMP dependent protein kinase A (PKA) with the native 1205-bp IGFBP-1 promoter construct stimulated IGFBP-1 promoter activity 3.9-fold , but the TAGCA mutation decreased by 73 % the ability of to *stimulate* [IGFBP-1] promoter activity above control levels . Positive_regulation IGFBP1 PRKAR1B 15722441 1389606 RLX enhanced [IGFBP-1] promoter activity was *inhibited* by cAMP dependent inhibitor , H-89 . Positive_regulation IGFBP1 PRKAR1B 7683658 216545 In addition , cotransfection of the catalytic subunit of cAMP dependent protein kinase A (PKA) with the native 1205-bp IGFBP-1 promoter construct stimulated IGFBP-1 promoter activity 3.9-fold , but the TAGCA mutation decreased by 73 % the ability of to *stimulate* [IGFBP-1] promoter activity above control levels . Positive_regulation IGFBP1 PRKAR2A 15722441 1389607 RLX enhanced [IGFBP-1] promoter activity was *inhibited* by cAMP dependent inhibitor , H-89 . Positive_regulation IGFBP1 PRKAR2A 7683658 216546 In addition , cotransfection of the catalytic subunit of cAMP dependent protein kinase A (PKA) with the native 1205-bp IGFBP-1 promoter construct stimulated IGFBP-1 promoter activity 3.9-fold , but the TAGCA mutation decreased by 73 % the ability of to *stimulate* [IGFBP-1] promoter activity above control levels . Positive_regulation IGFBP1 PRKAR2B 15722441 1389608 RLX enhanced [IGFBP-1] promoter activity was *inhibited* by cAMP dependent inhibitor , H-89 . Positive_regulation IGFBP1 PRKAR2B 7683658 216547 In addition , cotransfection of the catalytic subunit of cAMP dependent protein kinase A (PKA) with the native 1205-bp IGFBP-1 promoter construct stimulated IGFBP-1 promoter activity 3.9-fold , but the TAGCA mutation decreased by 73 % the ability of to *stimulate* [IGFBP-1] promoter activity above control levels . Positive_regulation IGFBP1 PTGS2 11108281 756835 A specific inhibitor , NS 398 ( 10 nM ) , partially *inhibited* [IGFBP-1] protein synthesis . Positive_regulation IGFBP1 PTH 1370164 179245 Based on previous work , we speculate that production of the 24/25-kDa [IGFBP] , which in vitro is known to inhibit IGF-I- and IGF-II mediated osteoblast function , may be *stimulated* by in patients with the syndrome of age related osteoporosis . Positive_regulation IGFBP1 PTH 1377704 190528 *increased* a 29-kDa [IGFBP] apparent only in UMR 106-01 cell conditioned medium , whereas GH had no direct effect on IGFBP secretion in any of the osteoblast-like cells tested . Positive_regulation IGFBP1 PTH 1703477 151360 In comparison , did not *stimulate* [IGFBP] production in fibroblasts and ROS 17/2.8 cells , which secrete IGFBPs of 42,000 , 38,000 , 34,000 , 28,000 , and 24,000 Mr , but not of 29,000 Mr. The PTH-responsive IGFBPs from UMR cells were nonglycosylated proteins with preferential affinity for IGF-I over IGF-II . Positive_regulation IGFBP1 RLN1 1697605 139591 Both IGF-I and insulin also blocked the *mediated* increase in [IGF-BP-1] . Positive_regulation IGFBP1 RLN1 7529731 284216 *Activation* of the human [IGFBP-1] gene promoter by progestin and in primary culture of human endometrial stromal cells . Positive_regulation IGFBP1 RLN2 1697605 139592 Both IGF-I and insulin also blocked the mediated *increase* in [IGF-BP-1] . Positive_regulation IGFBP1 RLN2 7529731 284217 *Activation* of the human [IGFBP-1] gene promoter by progestin and in primary culture of human endometrial stromal cells . Positive_regulation IGFBP1 RLN3 1697605 139593 Both IGF-I and insulin also blocked the *mediated* increase in [IGF-BP-1] . Positive_regulation IGFBP1 RLN3 7529731 284218 *Activation* of the human [IGFBP-1] gene promoter by progestin and in primary culture of human endometrial stromal cells . Positive_regulation IGFBP1 SELE 22198242 2563578 In adjusted mixed linear models , decreasing BMI was significantly associated with lower levels of soluble and IL-6 and *increases* in GH , adiponectin , and [IGFBP-1] . Positive_regulation IGFBP1 SETD2 16428465 1516033 These results suggest that *mediates* hypoxia induced [IGFBP-1] gene expression in early development by selectively interacting with the -1090/-1086 HRE and its adjacent HAS . Positive_regulation IGFBP1 SETD2 16990490 1673989 In contrast , *mediates* [IGFBP-1] transcription only in mice and in M. oeconomus ( subjected to severe hypoxia ) ; Positive_regulation IGFBP1 SETD2 23034716 2702601 Expression of a stabilized form of in zebrafish embryos *increased* the expression of [igfbp-1a] , a Hif-1 target gene , whereas it did not change hif-3a mRNA levels , suggesting that hif-3a is not a Hif-1a target . Positive_regulation IGFBP1 SLC25A3 10593604 572699 Treatment of B16F1 cells with inhibitors , sodium orthovanadate ( Na3VO4 ) and phenylarsine oxide ( PAO ) , or [PP-1/2A] *inhibitor* , okadaic acid ( OA ) , abolished cell movement . Positive_regulation IGFBP1 SP3 9329821 457481 The major difference of IGFBP-1 gene activation in endometrium and the hepatic system lies in the distal promoter region , between -2.6 and -3.4 kb , which mediates 95 % of the total promoter activity derived from -3.3 kb to +68 bp. Functional and binding analysis in the distal promoter region showed that multiple Sp1 elements interacting with a novel *activates* the [hIGFBP-1] gene promoter . Positive_regulation IGFBP1 SST 7683739 216563 Conversely , a 3-hour ( SRIF ) infusion *caused* a 4.5-fold increase in plasma [IGFBP-1] levels . Positive_regulation IGFBP1 STS 1379255 192990 , a potent PKC inhibitor , *stimulated* [IGFBP-1] production 2- to 4-fold and augmented the stimulatory effect of PMA . Positive_regulation IGFBP1 TEAD4 22843786 2676996 Furthermore , we demonstrated that *upregulates* [IGFBP-1] through selective binding and promotion of transcription from the insulin response element site . Positive_regulation IGFBP1 TFPI 9253353 447640 The findings suggest that , at plasma concentrations similar to those reached during physical stress , *stimulates* the production of [IGFBP-1] in humans . Positive_regulation IGFBP1 TGFB1 10366413 621173 Our results demonstrate that TGF-alpha and significantly *stimulate* IGF-I and [IGFBP] secretion by cultured hepatocytes but no change in the abundance of IGF-I and IGFBP mRNAs was observed with respect to controls . Positive_regulation IGFBP1 TGFB1 10830291 697396 In conclusion , vascular endothelial growth factor and *regulate* [IGFBP] expression in bovine aortic endothelial cells . Positive_regulation IGFBP1 TGFB1 7541944 310591 Utilizing Western ligand blot analysis , we found that at concentrations of 0.5 , 1.0 , and 2 ng/ml significantly *increased* levels of 32-kDa [IGFBP] in the conditioned medium ( CM ) of IEC-6 cells in a dose dependent fashion and that low doses of insulin ( 1.0 and 5.0 microgram/ml ) also increased IGFBP levels in the CM of IEC-6 cells , but a high dose of insulin ( 10 micrograms/ml ) depressed IGFBP release in the CM. Immunoblotting has shown that the IGFBP of 32 kDa was IGFBP-2 and further confirmed the above results . Positive_regulation IGFBP1 TNF 10226804 610457 We conclude that IL-1 alpha and *increase* circulating levels of [IGFBP-1] , reflecting direct effects on hepatic IGFBP-1 mRNA abundance . Positive_regulation IGFBP1 TNF 11735242 885712 also *increased* [IGFBP-1] in the blood ( 4-fold ) and this response was associated with an increase in IGFBP-1 mRNA expression in both liver ( 3-fold ) and kidney ( 9-fold ) . Positive_regulation IGFBP1 TP53 18056423 1833551 Here we show that transcriptional activation *leads* to enhanced expression of hepatic [IGFBP1] ( insulin-like growth factor binding protein-1 ) . Positive_regulation IGFBP1 TRNAI1 7680863 214164 dose-dependently *enhanced* [IGFBP-1] secretion in serum-free HepG2 cell cultures after 24-48 h of exposure , as measured by a specific immunofluorometric assay . Positive_regulation IGFBP1 VEGFA 10830291 697397 In conclusion , and transforming growth factor-beta1 *regulate* [IGFBP] expression in bovine aortic endothelial cells . Positive_regulation IGFBP2 IGFBP1 1370941 179562 In CM , [IGFBP-2] and IGFBP-3 were *detected* , as was a unique 24-kd , although IGFBP-1 was not observed . Positive_regulation IGFBP2 IGFBP1 15692833 1376313 Decreased renal filtration and increased hepatic production of and -2 both *contribute* to high levels of serum [IGFBP] . Positive_regulation IGFBP2 IGFBP1 7508947 244969 Although benign cysts contained almost no , high [IGFBP-2] levels were *detected* in malignant cysts regardless of histological type . Positive_regulation IGFBP3 IGFBP1 10470776 641400 The carrier protein [IGF-BP3] increased from 126 to 283 mg/L at the end of the study period , and the inhibiting decreased initially from 19 to 14 mg/L and then increased until the end of the study to 31 mg/L. Nitrogen balance *increased* initially from 4.6 to 13.6 g/24 hrs and thereafter decreased until the end of rHGH treatment to 8.3 g/24 hrs . Positive_regulation IGFBP3 IGFBP1 1370941 179569 In CM , IGFBP-2 and [IGFBP-3] were *detected* , as was a unique 24-kd , although IGFBP-1 was not observed . Positive_regulation IGFBP3 IGFBP1 1377124 190460 Basal expression was very low , but the addition of mPL-I , or mPL-II *stimulated* a marked increase in the amount of 29K IGFBP that was released into the CM and a lesser increase in the release of [IGFBP-3] . Positive_regulation IGFBP3 IGFBP1 15692833 1376315 Decreased renal filtration and increased hepatic production of and -2 both *contribute* to high levels of serum [IGFBP] . Positive_regulation IGFBP3 IGFBP1 1719017 169486 With advancing age and pubertal status , declined and [IGFBP-3] *increased* significantly in the control , but not the diabetic group . Positive_regulation IGFBP3 IGFBP1 7520318 266282 Mean serum levels were normal , but mean serum [IGFBP-3] levels were significantly *increased* , while a significant negative correlation was found between the GFR and serum IGFBP-3 levels . Positive_regulation IGFBP3 IGFBP1 7589849 334105 By contrast , IGF-I and [IGFBP-3] were unaltered by corticosterone in the 30 STZ Ax rats , and *increased* in proportion with the dose of corticosterone . Positive_regulation IGFBP3 IGFBP1 7691864 231019 Plasma immunoreactive IGF-I and IGF-II , and serum levels were normal , but serum levels of [IGFBP-3] were *increased* . Positive_regulation IGFBP3 IGFBP1 9124573 424035 Both peptides enhanced expression of and 2 and *induced* [IGFBP-3] in the older rats . Positive_regulation IGFBP3 IL1B 7544275 318243 *increased* the average transcription rate of [IGFBP-3] by 3.3-fold . Positive_regulation IGFBP3 IL1B 7544275 318244 The immunoblot of cell conditioned media showed that the basal level of IGFBP-3 protein was low and *caused* a dose dependent increase in the production of [IGFBP-3] . Positive_regulation IGFBP3 IL1B 7544275 318245 The addition of cycloheximide markedly inhibited *induced* [IGFBP-3] mRNA levels . Positive_regulation IGFBP3 IL1B 7544275 318247 In conclusion , inhibits IGF-I but *increases* [IGFBP-3] expression in Leydig cells , and this may contribute to the inhibitory effects of IL-1 beta on Leydig cell steroidogenesis . Positive_regulation IGFBP3 PLAT 9714057 527625 The increased [IGFBP-3] proteolysis most probably *resulted* from amplified expression of and depression of its inhibitor ( PAI-I ) observed in IGFBP-2 expressing xenografts . Positive_regulation IGFBP3 PLAU 17121915 1652266 The specific *role* of in anti-invasive activity of [IGFBP-3] was further confirmed in NSCLC cells , in which uPA expression/activity was suppressed by the transfection with synthetic small interfering RNA or by the treatment with uPA inhibitor or induced by the infection with an adenoviral vector . Positive_regulation IGFBP3 TNF 12584730 1058774 Histological analysis and immunocytochemical staining confirmed that specifically *increases* [IGFBP-3] and IGFBP-4 immunoreactivity , as well as that of the IGF1R , in radial glial and Purkinje cells . Positive_regulation IGFBP3 TNF 17029675 1797569 increased basal and *augmented* F-mediated [IGFBP-3] gene expression . Positive_regulation IGFBP3 TNF 17029675 1797570 In the presence of PI and high BSA , media [IGFBP-3] levels were shown to be *increased* by consistent with the gene expression data . Positive_regulation IGFBP3 TNF 19259947 2062928 Here we show that *requires* the SAPK pathway p38 , but not JNK , to induce [IGFBP-3] expression . Positive_regulation IGFBP3 TNF 21383009 2426708 Using human epithelial cells , we demonstrated the following : 1 ) [IGFBP-3] blocks *induced* expression of proinflammatory molecules ; Positive_regulation IGFBP3 TNF 7561640 328323 Interleukin-1 and *increase* insulin-like growth factor binding protein-3 ( IGFBP-3 ) production and [IGFBP-3] protease activity in human articular chondrocytes . Positive_regulation IGFBP3 TNF 7561640 328338 Both IL-1 alpha and *increased* chondrocyte production of [IGFBP-3] , but did not alter IGFBP-4 production . Positive_regulation IGFBP3 TNF 8536626 346055 *stimulated* predominantly [IGFBP-3] ( about 4-fold ) both in terms of mRNA ( a 2.6-kilobase transcript , measured by Northern blotting analysis ) , and protein ( a doublet of 40-44 kDa , assessed by ligand blotting analysis ) . Positive_regulation IGFBP3 TNF 9735418 531238 The increased [IGFBP-3] accumulation *induced* by is correlated with increased IGFBP-3 mRNA abundance . Positive_regulation IGFBP3 TNF 9735418 531239 Finally , we demonstrate that an IGFBP-3 antisense oligodeoxynucleotide antagonizes *induced* inhibition of cell proliferation and TNF-alpha induced [IGFBP-3] accumulation . Positive_regulation IGFBP3 TP63 15713654 1373992 In addition , we identified that histone deacetylase activity , not p53 DNA binding ability , governs the regulation of IGFBP3 by full-length p53 family proteins , as inhibition of histone deacetylases restores the *induction* of [IGFBP3] by exogenous full-length p53 , , and p73 proteins . Positive_regulation IGFBP4 IGFBP1 12376561 996892 Cell attachment to a general ECM gel was unaffected by and -6 but was significantly *increased* by [IGFBP-4] and -5 and decreased by IGFBP-2 and -3 . Positive_regulation IGFBP4 IGFBP1 15692833 1376317 Decreased renal filtration and increased hepatic production of and -2 both *contribute* to high levels of serum [IGFBP] . Positive_regulation IGFBP4 TNF 10192430 603652 In contrast , [IGFBP4] was not regulated in *response* to IL-6 , , PDGF BB , bFGF , TGF-beta or the cAMP agonist , forskolin . Positive_regulation IGFBP4 TNF 12584730 1058775 Histological analysis and immunocytochemical staining confirmed that specifically *increases* IGFBP-3 and [IGFBP-4] immunoreactivity , as well as that of the IGF1R , in radial glial and Purkinje cells . Positive_regulation IGFBP5 ANO1 23576565 2799906 *regulates* growth and [IGFBP5] in gastrointestinal stromal tumors . Positive_regulation IGFBP5 IGFBP1 10792618 689453 The IGFBP-5 stimulatory pathway is mediated by the serine/threonine kinase [IGFBP-5] receptor , which is *activated* by the carboxy-terminal peptide . Positive_regulation IGFBP5 IGFBP1 12376561 996894 Cell attachment to a general ECM gel was unaffected by and -6 but was significantly *increased* by [IGFBP-4 and -5] and decreased by IGFBP-2 and -3 . Positive_regulation IGFBP5 IGFBP1 15692833 1376319 Decreased renal filtration and increased hepatic production of and -2 both *contribute* to high levels of serum [IGFBP] . Positive_regulation IGFBP5 MAP2K6 20127863 2248427 Furthermore , expression *activated* p38 and C/EBPalpha , increasing [IGFBP-5] promoter activity and expression . Positive_regulation IGFBP6 IGFBP1 15692833 1376321 Decreased renal filtration and increased hepatic production of and -2 both *contribute* to high levels of serum [IGFBP] . Positive_regulation IGFBP7 FOXO1 24983498 2952611 [SET/TAF-Iß] interacted with FoxO1 and *activated* transcription of target gene , p21 . Positive_regulation IGFBP7 IGFBP1 15692833 1376323 Decreased renal filtration and increased hepatic production of and -2 both *contribute* to high levels of serum [IGFBP] . Positive_regulation IGKV1-17 IL1B 9394732 468151 [A 30-fold] *induction* of collagenase mRNA and collagenase protein secretion by was completely abrogated by dexamethasone . Positive_regulation IGKV1-27 TNF 11009421 735892 dramatically *increases* [A20] messenger RNA expression in all tissues . Positive_regulation IGKV1-27 TNF 15862966 1401048 [A20] gene expression is *regulated* by , Vitamin D and androgen in prostate cancer cells . Positive_regulation IGKV1-27 TNF 15862966 1401051 *induced* [A20] gene expression in both cell lines , but with different effect . Positive_regulation IKBKAP EPHB2 9689078 522749 We have previously shown that mitogen activated protein kinase kinase 1 ( MEKK1 ) can *induce* both this site-specific phosphorylation of IkappaB alpha at Ser-32 and Ser-36 in vivo and the activity of a high molecular weight [IkappaB kinase complex] in vitro . Positive_regulation IKBKAP IL1B 15550384 1360967 Iron mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha induced but not *induced* [IkappaB kinase complex/nuclear] factor-kappaB activation . Positive_regulation IKBKAP TNF 12867425 1141845 A role for NF-kappaB essential modifier/IkappaB kinase-gamma ( NEMO/IKKgamma ) ubiquitination in the *activation* of the [IkappaB kinase complex] by . Positive_regulation IKBKB CST6 21182083 2373770 plus IFN-? *activated* the [IKK complex] to induce phosphorylation mediated degradation of p105 , the physiological partner and inhibitor of the MEK kinase , tumor progression locus 2 (Tpl-2) . Positive_regulation IKBKB CTGF 19301259 2064252 Stimulation of JJ012 cells with also *induced* [IkappaB kinase alpha/beta] ( IKK alpha/beta ) phosphorylation , IkappaBalpha phosphorylation , p65 Ser ( 536 ) phosphorylation , and kappaB-luciferase activity . Positive_regulation IKBKB EPHB2 23563696 2794502 Induction in gastric mucosal prostaglandin and nitric oxide by Helicobacter pylori is dependent on *mediated* activation of [IKK-ß] and cPLA2 : modulatory effect of ghrelin . Positive_regulation IKBKB EPHB2 9689078 522763 We have previously shown that mitogen activated protein kinase kinase 1 ( MEKK1 ) can *induce* both this site-specific phosphorylation of IkappaB alpha at Ser-32 and Ser-36 in vivo and the activity of a high molecular weight [IkappaB kinase complex] in vitro . Positive_regulation IKBKB FAS 20212524 2223117 We validated experimentally that stimulation *resulted* in an interaction of p43-FLIP with the [IKK complex] followed by its activation . Positive_regulation IKBKB IL1B 10391945 626981 However , [IKK] activity was strongly *induced* by TNF-alpha but not by . Positive_regulation IKBKB IL1B 11976320 953948 Under these conditions or upon overexpression of wild type Akt , *induced* [IKKbeta] activity is diminished . Positive_regulation IKBKB IL1B 11976320 953959 Furthermore , a dominant negative mutant of Akt abolishes IKKbeta inhibition by CaMKKc and ionomycin , suggesting that Akt acts as a mediator of CaMKK signaling to inhibit *induced* [IKK] activity at an upstream target site . Positive_regulation IKBKB IL1B 15077173 1265810 Short-time inhibition of Hsp90 resulted in impaired [IKK] kinase *activation* by TNFalpha , or phorbolester PMA . Positive_regulation IKBKB IL1B 15304320 1284622 15-Deoxy-delta ( 12,14 ) -prostaglandin J ( 2 ) inhibits *induced* [IKK] enzymatic activity and IkappaBalpha degradation in rat chondrocytes through a PPARgamma independent pathway . Positive_regulation IKBKB IL1B 15550384 1360968 Iron mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha induced but not *induced* [IkappaB kinase complex/nuclear] factor-kappaB activation . Positive_regulation IKBKB IL1B 15550384 1360978 Cleavage and degradation of TNF pathway components TNFR1 , RIP , and Hsp90 were observed in l-mimosine and H ( 2 ) O ( 2 ) treated cells indicating a putative mechanism for selective inhibition of TNF but not *induced* [IKK] activation . Positive_regulation IKBKB IL1B 16354686 1504429 Clearance of both superoxide and H2O2 from within the endosomal compartment significantly abrogated *dependent* [IKK] and NF-kappaB activation . Positive_regulation IKBKB IL1B 19369446 2081692 PD-98059 blocked *induced* phosphorylation of [IKK2] , degradation of IkappaB-alpha , and phosphorylation and nuclear translocation of NF-kappaB subunit p65 , whereas SB-203580 had a marginal effect , implying that the effect of ERK1/2 is exerted on the canonical IKK2/IkappaB-alpha/p65 pathway of NF-kappaB activation but that the effect of p38 MAPK may not predominantly involve NF-kappaB signaling . Positive_regulation IKBKB IL1B 19369446 2081721 Inhibition of GSK3beta abolished *induced* phosphorylation of [IKK2/p65] . Positive_regulation IKBKB IL1B 19854138 2155749 A ubiquitin replacement strategy in human cells reveals distinct mechanisms of [IKK] *activation* by TNFalpha and . Positive_regulation IKBKB IL1B 19854138 2155758 We demonstrate that K63 of ubiquitin and the catalytic activity of Ubc13 , an E2 that catalyzes K63 polyubiquitination , are required for [IKK] *activation* by , but surprisingly , not by TNFalpha . Positive_regulation IKBKB IL1B 20038579 2205269 Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and *induced* [IKK/NF-kappaB] and JNK/AP-1 activation . Positive_regulation IKBKB MAP2K6 16584774 1665813 Together , we interpret these data as demonstrating that the activation caused by loss of Gimap5 is a cell intrinsic phenomenon caused , in part , by a *dependent* activation of [IKK] . Positive_regulation IKBKB MAP2K6 24466036 2907709 In addition , activation of NF?B via the MAPK pathway is regulated through *induced* activation of [IKK] . Positive_regulation IKBKB NEDD9 11297557 819955 By using a specific anti-phosphopeptide antibody , it was confirmed that [IKK2] overexpression *induces* serine 927 phosphorylation of co-transfected and that endogenous p105 is also rapidly phosphorylated on this residue after TNFalpha or IL-1alpha stimulation . Positive_regulation IKBKB NEDD9 19754427 2153297 In these cells IL-1 does not activate [IKKbeta] or *induce* the phosphorylation of , and nor does the IKKbeta inhibitor PS1145 prevent the IL-1 induced activation of transfected Tpl2 . Positive_regulation IKBKB TGM2 16987813 1640586 Recently we reported that *activates* nuclear factor-kappaB (NF-kappaB) [independently of I-kappaB kinase (IKK)] activation , by inducing cross linking and protein polymer formation of inhibitor of nuclear factor-kappaBalpha ( I-kappaBalpha ) . Positive_regulation IKBKB TLR7 22473004 2589057 NLRC5 ablation reduces MHC class I expression , and enhances [IKK] and IRF3 phosphorylation in *response* to stimulation or viral infection . Positive_regulation IKBKB TNF 10022904 590580 In contrast , the inhibition of alphaPKC does not affect the *activation* of [IKKbeta] by . Positive_regulation IKBKB TNF 10195894 604018 In mammalian cells , phosphorylation of two sites at the activation loop of IKKbeta was essential for *activation* of [IKK] by and interleukin-1 . Positive_regulation IKBKB TNF 10384145 624795 [IKK] activity in both RA and osteoarthritis FLS was strongly *induced* by and IL-1 in a concentration dependent manner . Positive_regulation IKBKB TNF 10391945 626980 However , [IKK] activity was strongly *induced* by but not by IL-1beta . Positive_regulation IKBKB TNF 10553091 565540 This study shows that the sesquiterpene lactone parthenolide inhibits a common step in NF-kappa B activation by preventing the *induced* [induction of I kappa B kinase (IKK)] and IKK beta , without affecting the activation of p38 and c-Jun N-terminal kinase . Positive_regulation IKBKB TNF 10788610 688951 NAC also suppressed the induced *activation* of IKKalpha and [IKKbeta] , phosphorylation and degradation of IkappaB , and nuclear translocation of NF-kappaB . Positive_regulation IKBKB TNF 10820281 694439 Auranofin also blocked [IKK] activation *induced* by and PMA/ionomycin , suggesting that the target of auranofin action is common among these diverse signal pathways . Positive_regulation IKBKB TNF 10946303 722956 [IKK] activity was *stimulated* by both and TPA , and these effects were inhibited by staurosporine or herbimycin . Positive_regulation IKBKB TNF 11096064 802170 Thus , OFF inhibits induced [IKK] *activation* , leading to a decrease in phosphorylation and degradation of inhibitory IkappaBalpha , which in turn results in the decrease of TNF-alpha induced NF-kappaB activation and potentially the transcription of target genes . Positive_regulation IKBKB TNF 11133741 769358 However , D609 and the specific p38 inhibitor SB202190 did not affect NiCl ( 2 ) - and *induced* [IKKbeta] activation , NF-kappaB DNA binding activity , or transcriptional activity of a Gal4p65 fusion protein . Positive_regulation IKBKB TNF 11179444 784698 [IKK] activity was *stimulated* by either or C2-ceramide , and these effects were inhibited by PD98059 or SB203580 . Positive_regulation IKBKB TNF 11356844 834415 Activation of phosphatidylinositol (PI) 3-kinase/Akt signaling by *activates* [IKK] and NF-kappaB . Positive_regulation IKBKB TNF 11359906 816586 The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2 dependent [IKK] recruitment to tumor necrosis factor (TNF) receptor 1 in *response* to . Positive_regulation IKBKB TNF 11359906 816592 In *response* to the proinflammatory cytokine , [IKK] is activated after being recruited to the TNF receptor 1 (TNF-R1) complex via TNF receptor associated factor 2 (TRAF2) . Positive_regulation IKBKB TNF 11359906 816599 Importantly , IKKgamma is not essential for *induced* [IKK] recruitment to TNF-R1 , as this occurs efficiently in IKKgamma-deficient cells . Positive_regulation IKBKB TNF 11429546 831657 The molecular mechanism that underlies [IKK] activation in *response* to is still unknown . Positive_regulation IKBKB TNF 11479295 860526 Since oxidants have been implicated in the regulation of NF-kappaB , the focus of the present study was the *activation* of [IKK] by in the presence or absence of hydrogen peroxide ( H ( 2 ) O ( 2 ) ) . Positive_regulation IKBKB TNF 11479295 860544 In contrast , *induced* [IKK] activity rapidly and transiently resulting in IkappaBalpha degradation and NF-kappaB activation . Positive_regulation IKBKB TNF 11479295 860547 Importantly , in the presence of H ( 2 ) O ( 2 ) , the ability of to *induce* [IKK] activity was markedly decreased and resulted in prevention of IkappaBalpha degradation and NF-kappaB activation . Positive_regulation IKBKB TNF 11483407 844326 [IKK] activity was *stimulated* by both and TPA , and these effects were inhibited by Ro 31-8220 or tyrphostin 23 . Positive_regulation IKBKB TNF 11799112 922268 PTEN failed to block induced [IKK] *activation* , IkappaBalpha degradation , p105 processing , p65 ( RelA ) nuclear translocation , and DNA binding of NF-kappaB . Positive_regulation IKBKB TNF 11864612 917602 *induced* recruitment and activation of the [IKK complex] require Cdc37 and Hsp90 . Positive_regulation IKBKB TNF 11864612 917624 Geldanamycin ( GA ) , an antitumor agent that disrupts the formation of this heterocomplex , prevents induced *activation* of [IKK] and NF-kappaB . Positive_regulation IKBKB TNF 11954826 930701 Hyperoxia alone did not induce IkappaB kinase (IKK) activity , but significantly prolonged mediated *activation* of [IKK] activity . Positive_regulation IKBKB TNF 11967992 938073 Binding of to its receptor *activates* [IKK complex] , which leads to inducement of NF-kappaB activity . Positive_regulation IKBKB TNF 12023051 943493 stimulation *increased* [IKK] activity within 10 min , and then IKK activity decreased gradually within 30 min in HeLa cells . Positive_regulation IKBKB TNF 12121873 965122 mediated [IKK] *activation* leads to IkappaBalpha and IkappaBbeta degradation . Positive_regulation IKBKB TNF 12181188 977498 In conclusion , Fe2+ serves as a direct agonist to activate [IKK] , NF-kappaB , and TNF-alpha promoter activity and to *induce* the release of protein by cultured Kupffer cells in a redox status dependent manner . Positive_regulation IKBKB TNF 12192055 980844 Substitution of two leucines within a C-terminal leucine zipper motif markedly reduced [IKK] *activation* by and IL-1 . Positive_regulation IKBKB TNF 12192055 980850 Another point mutation resulting in a cysteine-to-serine substitution within the putative Zn finger motif affected [IKK] *activation* by but not by IL-1 . Positive_regulation IKBKB TNF 12645577 1069708 Substitution of these residues with phenylalanines abolished ICAM-1 promoter activity and c-Src dependent phosphorylation of [IKKbeta] *induced* by or TPA . Positive_regulation IKBKB TNF 12692090 1093272 Only at high concentrations , cPG enhanced TNF-alpha induced cell death and inhibited *induced* [IkappaB-alpha kinase (IKK)] activation , IkappaB-alpha degradation , and NF-kappaB/p65 translocation , while promoting AP-1/c-jun phosphorylation . Positive_regulation IKBKB TNF 12707358 1082858 Substitution of these residues with phenylalanines attenuated COX-2 promoter activity and c-Src dependent phosphorylation of [IKKbeta] *induced* by or TPA . Positive_regulation IKBKB TNF 12842894 1134793 induced [IKK] phosphorylation of NF-kappaB p65 on serine 536 is *mediated* through the TRAF2 , TRAF5 , and TAK1 signaling pathway . Positive_regulation IKBKB TNF 12867425 1141846 A role for NF-kappaB essential modifier/IkappaB kinase-gamma ( NEMO/IKKgamma ) ubiquitination in the *activation* of the [IkappaB kinase complex] by . Positive_regulation IKBKB TNF 12867425 1141852 Mutations of the zinc finger are found in patients with hypohidrotic ectodermal dysplasia with immunodeficiency ( HED-ID ) and lead to the impairment of *stimulated* [IKK] phosphorylation and activation . Positive_regulation IKBKB TNF 12867425 1141858 Thus , the ubiquitination of NEMO mediated by c-IAP1 likely plays an important role in the *activation* of [IKK] by . Positive_regulation IKBKB TNF 12934647 1132833 IL-1beta and can *induce* extracellular signal regulated kinase ( ERK ) , [IKK] , IkappaB degradation and NF-kappaB activation . Positive_regulation IKBKB TNF 12939259 1157878 However , expression of the adaptor protein RIP , which is essential for [IKK] *activation* by , was decreased in cells exposed to H2O2 , and its chaperone Hsp90 was cleaved . Positive_regulation IKBKB TNF 14764716 1207363 The *activation* of the [I-kappaB kinase (IKK)] complex by or LPS stimulates phosphorylation and degradation of I-kappaBalpha , leading to the nuclear translocation of NF-kappaB . Positive_regulation IKBKB TNF 15106733 1240545 plus IFN-gamma can *induce* extracellular signal regulated kinase ( ERK ) , [IKK] , IkappaB degradation and NF-kappaB activation . Positive_regulation IKBKB TNF 15175328 1273489 *induced* [Ikk] and p38 MAP kinase activation is normal , and the Rip1D138N cells are resistant to TNF-alpha induced cell death , indicating that the kinase activity of Rip1 is not required to mediate its antiapoptotic functions . Positive_regulation IKBKB TNF 15302572 1283880 *induced* activation of [IKK] was suppressed by HS in human bronchial epithelial cells , and this was associated with the absence of IKK in the immunoprecipitates . Positive_regulation IKBKB TNF 15302572 1283883 Overexpression of NIK resumed induced *activation* of [IKK] in thermotolerant cells . Positive_regulation IKBKB TNF 15310755 1303551 At the same time , the binding of AIP1 to TRAF2 inhibits *induced* [IKK-NF-kappaB] signaling . Positive_regulation IKBKB TNF 15550384 1360973 Here we show that l-mimosine , a toxic non-protein amino acid that has been shown to reduce serum TNFalpha levels and affect inflammatory responses , specifically inhibits *induced* [IKK] but not JNK in a cell type-specific manner . Positive_regulation IKBKB TNF 15647756 1363640 In this study , we have compared *induced* activation of NF-kappaB , phosphorylation of IkappaBalpha , and the expression of [IKKbeta] between lymphocytes from young and aged humans . Positive_regulation IKBKB TNF 15710601 1395743 Evodiamine also inhibited *induced* Akt activation and its association with [IKK] . Positive_regulation IKBKB TNF 16126728 1467075 This pathway is initiated by *dependent* phosphorylation of T loop serines in [IKKbeta] , which greatly stimulates IkappaB kinase activity . Positive_regulation IKBKB TNF 16166517 1456570 Although *induced* [IKK] activity was rapidly attenuated by negative feedback , lipopolysaccharide (LPS) signaling and LPS-specific gene expression programs were dependent on a cytokine mediated positive feedback mechanism . Positive_regulation IKBKB TNF 16246929 1471541 We found that both and LPS *activated* the [I-kappa B kinase complex (IKK)] in DPSCs to induce the phosphorylation and degradation of IkappaBalpha , resulting in the nuclear translocation of NF-kappaB . Positive_regulation IKBKB TNF 16490171 1528586 NAC inhibited the phosphorylation of [IKKbeta] , IKK alpha , and IkappaB alpha *induced* by , but had no effect on the phosphorylation of IKKbeta , IKK alpha and IkappaB alpha induced by IL-1 . Positive_regulation IKBKB TNF 16490171 1528604 NAC can inhibit the processes upstream of [IKK] activation *induced* by , which results in the decline of NF-kappaB activity . Positive_regulation IKBKB TNF 16603398 1550699 *Activation* of [IKK] by requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO . Positive_regulation IKBKB TNF 16611882 1545336 Similarly , IKKgamma-delta mediates [IKK] kinase activity and downstream NF-kappaB dependent transcription in *response* to and the NF-kappaB inducing kinase-IKKalpha signaling pathway . Positive_regulation IKBKB TNF 16723255 1570412 *induces* chromosomal abnormalities independent of ROS through [IKK] , JNK , p38 and caspase pathways . Positive_regulation IKBKB TNF 16774932 1672081 The use of Ro-318220 and GO-6983 , general PKC inhibitors as well as MG-132 , a proteasome-specific inhibitor , abrogated PMA induced degradation of IKK-gamma and recovered the *activation* of [IKK] by , suggesting that IKK complex is predominantly degraded by the proteasome pathway in a PKC dependent manner . Positive_regulation IKBKB TNF 16872805 1672442 Ad.IKKbeta+/- treatment completely inhibited *stimulated* [IKK] kinase activity , IkappaB alpha degradation and NFkappaB DNA binding in addition to completely blocking TNFalpha stimulated ICAM-1 and VCAM-1 expression . Positive_regulation IKBKB TNF 16916935 1608532 Conversely , GRX1 knockdown sensitizes cells to oxidative inactivation of IKK-beta and dampens *induced* [IKK] and NF-kappaB activation . Positive_regulation IKBKB TNF 16987412 1628287 *mediated* activation of [IKK-beta] resulted in activation of NF-kappaB and was followed by up-regulation of the bona-fide target gene cyclin D1 . Positive_regulation IKBKB TNF 17079781 1708983 Nox1 expression and activation inhibited *induced* [inhibitor of kappaB kinase (IKK)] , and NF-kappaB while promoting JNK activation and cell death . Positive_regulation IKBKB TNF 17110449 1732121 Recent studies indicate that induced [IKK] *activation* requires activation of TAK1 , and we indeed found that celastrol inhibited the TAK1 induced NF-kappaB activation . Positive_regulation IKBKB TNF 17158449 1694236 A green fluorescent protein fusion protein containing the last 100 residues of TAK1 ( TAK1-C100 ) abolished the interaction of endogenous TAB2/TAB3 with TAK1 , the phosphorylation of TAK1 , and prevented the activation of [IKK] and MAPK *induced* by IL-1 , , and RANKL . Positive_regulation IKBKB TNF 17240450 1696455 Mechanistically , a non-radioactive IkappaB kinases (IKK) assay using immunoprecipitated IKKs protein demonstrated that magnolol inhibited both intrinsic and *stimulated* [IKK] activity , thus suggesting a critical role of magnolol in abrogating the phosphorylation and degradation of IkappaBalpha . Positive_regulation IKBKB TNF 17244613 1710248 Our results therefore demonstrate that NEMO and IKKalpha can form a functional [IKK complex] that activates the classical NF-kappaB pathway in *response* to IL-1 but not . Positive_regulation IKBKB TNF 17544371 1751872 Stable expression of TRIP or a RING mutant did not affect [IKK] activation *induced* by or IL-1 and had no affect on TNF induced apoptosis . Positive_regulation IKBKB TNF 17690092 1800498 With moderate GSH depletion ( approximately 50 % ) , the down-regulation is IkappaB kinase (IKK) independent and likely acts on NF-kappaB transcriptional activity because induced [IKK] *activation* , IkappaBalpha phosphorylation and degradation , NF-kappaB nuclear translocation , NF-kappaB DNA binding in vitro , and NF-kappaB subunit RelA ( p65 ) recruitment to kappaB sites of target gene promoters all appear unaltered . Positive_regulation IKBKB TNF 17940218 1830561 The present study demonstrates that the globular domain of adiponectin ( gAd ) potently suppresses the *activation* of [IKKbeta] by either or high glucose in human umbilical vein endothelial cells and ameliorates the associated loss of IkappaBalpha protein . Positive_regulation IKBKB TNF 17940218 1830562 Interestingly , activation of AMP kinase was substantially more effective than cAMP signaling in suppressing high glucose induced IKKbeta activity , whereas both pathways were comparably active in suppressing the *induced* increase in [IKKbeta] . Positive_regulation IKBKB TNF 18037881 1832654 Studies in non-malignant epithelial cells show that MUC1 is recruited to the TNF-R1 complex and interacts with [IKKbeta-IKKgamma] in *response* to stimulation . Positive_regulation IKBKB TNF 18411264 1914323 *Activation* of [IKKbeta] by gamma radiation or led to increased TAp63gamma protein levels in cells . Positive_regulation IKBKB TNF 18644347 1947739 however , Celecoxib had no effect on *induced* [IKK] activation and degradation of IkappaBalpha and IkappaBbeta , suggesting that it inhibited NF-kappaB activation via suppressing downstream of IKK activation and IkappaBs degradation . Positive_regulation IKBKB TNF 18930133 2013548 PPM1A and PPM1B act as IKKbeta phosphatases to terminate *induced* [IKKbeta-NF-kappaB] activation . Positive_regulation IKBKB TNF 18930133 2013559 PPM1A and PPM1B associate with the phosphorylated form of IKKbeta , and the interaction between PPM1A/PPM1B and [IKKbeta] is *induced* by in a transient fashion in the cells . Positive_regulation IKBKB TNF 18930133 2013568 Furthermore , knockdown of PPM1A and PPM1B expression enhances *induced* [IKKbeta] phosphorylation , NF-kappaB nuclear translocation and NF-kappaB dependent gene expression . Positive_regulation IKBKB TNF 18957422 2001134 Expressing a constitutively active Plk1 in mammalian cells reduced induced [IKK] *activation* , resulting in decreased phosphorylation of endogenous IkappaBalpha and reduced NF-kappaB activation . Positive_regulation IKBKB TNF 18957422 2001139 To activate endogenous Plk1 , cells were treated with nocodazole , which reduced induced [IKK] *activation* , and increased the phosphorylation of gammaBD . Positive_regulation IKBKB TNF 18957422 2001143 Knocking down Plk1 in mammalian cells restored induced [IKK] *activation* in nocodazole treated cells . Positive_regulation IKBKB TNF 18957422 2001151 Moreover , we identify Plk1 as a gammaBD kinase , which negatively regulates *induced* [IKK] activation and cyclin D1 expression , thereby affecting cell cycle regulation . Positive_regulation IKBKB TNF 18981220 2015201 These results unveil a new , finely tuned mechanism for induced [IKK] *activation* modulated by TRAF2 phosphorylation and suggest that TRAF2 phosphorylation contributes to elevated levels of basal NF-kappaB activity in certain human cancers . Positive_regulation IKBKB TNF 19010928 1991634 Therefore , inhibition of *induced* [IKK] activity with specific IKK inhibitor represents an attractive strategy to treat cancer patients . Positive_regulation IKBKB TNF 19010928 1991643 This study reveals IKI-1 as a potent small molecule inhibitor of IKKalpha and IKKbeta , which effectively blocked mediated [IKK] *activation* and subsequent NF-kappaB activity . Positive_regulation IKBKB TNF 19091594 2031055 Moreover , the reintroduction of exogenous TRAF6 into TRAF6-deficient MEFs clearly suppressed induced [IKK] *activation* , NF-kappaB activation and subsequent cytokine expression . Positive_regulation IKBKB TNF 19091594 2031060 In contrast , both the deletion mutant ( DeltaN ) and the point mutant ( C70A ) of TRAF6 , which is defective in its ubiquitin ligase activity , failed to repress induced [IKK] *activation* , NF-kappaB activation and cytokine production . Positive_regulation IKBKB TNF 19181934 2043862 Inhibition of ERK 1/2 MAPK with PD98059 attenuated the protective role of IL-10 against induced *activation* of [IKK] and NF kappaB as well as cardiomyocyte apoptosis . Positive_regulation IKBKB TNF 19202066 2044209 We also found that high glucose induced the O-GlcNAcylation of IKKbeta and sustained the *dependent* [IKKbeta] activity . Positive_regulation IKBKB TNF 19336568 2056510 Although many serine/threonine kinases have been implicated in induced [IKK] *activation* and NF-kappaB dependent gene expression , most of them do not directly activate IKK . Positive_regulation IKBKB TNF 19336568 2056515 These results reveal a new level of complexity in induced [IKK] *activation* modulated by TRAF2 phosphorylation and suggest that TRAF2 phosphorylation is one of the events that are responsible for elevated basal NF-kappaB activity in certain human cancers . Positive_regulation IKBKB TNF 19409903 2082510 TRAF2 suppresses basal IKK activity in resting cells and can *activate* [IKK] in TRAF2 and TRAF5 double knockout cells . Positive_regulation IKBKB TNF 19409903 2082517 Although TNFalpha induced receptor interacting protein 1 ubiquitination is indeed impaired in T2/5 DKO cells , stimulation further *increases* [IKK] activity in these cells , resulting in significantly elevated expression of NF-kappaB target genes to a level higher than that in wild-type cells . Positive_regulation IKBKB TNF 19409903 2082520 Inhibition of NIK in T2/5 DKO cells attenuates basal IKK activity and restores robust induced [IKK] *activation* to a level comparable with that seen in wild-type cells . Positive_regulation IKBKB TNF 19409903 2082523 This suggests that can *activate* [IKK] in the absence of TRAF2 and TRAF5 expression and receptor interacting protein 1 ubiquitination . Positive_regulation IKBKB TNF 19591457 2122801 TPCK inhibited *induced* [IKK] activation and directly blocked IKK activity in vitro . Positive_regulation IKBKB TNF 19592502 2137141 In contrast , a structurally related compound , echinatin , failed to inhibit induced [IKK] *activation* and NF-kappaB activation , suggesting that the 1,1-dimethy-2-propenyl group in licochalcone A is important for the inhibition of NF-kappaB . Positive_regulation IKBKB TNF 19766100 2147413 *induces* HIF-1alpha expression through activation of [IKKbeta] . Positive_regulation IKBKB TNF 19854138 2155748 A ubiquitin replacement strategy in human cells reveals distinct mechanisms of [IKK] *activation* by and IL-1beta . Positive_regulation IKBKB TNF 19854138 2155756 We demonstrate that K63 of ubiquitin and the catalytic activity of Ubc13 , an E2 that catalyzes K63 polyubiquitination , are required for [IKK] *activation* by IL-1beta , but surprisingly , not by . Positive_regulation IKBKB TNF 19854138 2155770 We further show that [IKK] *activation* by requires Ubc5 , which functions with the E3 cIAP1 to catalyze polyubiquitination of RIP1 not restricted to K63 of ubiquitin . Positive_regulation IKBKB TNF 19877072 2160722 In sharp contrast , DEX did not affect *induced* [IKK] phosphorylation , IkappaBalpha degradation , p65 nuclear translocation , or MAPK activation in RA FLS . Positive_regulation IKBKB TNF 20064526 2205520 The TRAF2 RING domain mediated polyubiquitination of RIP1 is believed to be essential for induced [IKK] *activation* , and the RING-domain deleted TRAF2 ( TRAF2-DeltaR ) has been widely used as a dominant negative in transient overexpression systems to block TNFalpha induced JNK and IKK activation . Positive_regulation IKBKB TNF 20064526 2205524 Here , we report that stable expression of TRAF2-DeltaR at a physiological level in TRAF2 and TRAF5 double knockout ( TRAF2/5 DKO ) cells almost completely restores normal *induced* [IKK] activation , but not RIP1 polyubiquitination . Positive_regulation IKBKB TNF 20064526 2205529 ( ii ) RIP1 polyubiquitination is not essential for *induced* [IKK activation; and (iii)] prolonged JNK activation has no obligate role in TNFalpha induced cell death . Positive_regulation IKBKB TNF 20082310 2212588 Stimulation of myoblasts with *activated* [IkappaB kinase alpha/beta] ( IKKalpha/beta ) , IkappaBalpha phosphorylation , p65 phosphorylation , and kappaB-luciferase activity . Positive_regulation IKBKB TNF 20153843 2236127 Whereas Licochalcone A potently inhibited *induced* [IKK] activation , IkappaBalpha degradation , nuclear localization of NF-kappaB and its DNA binding activity , no inhibitory effect was observed by reduced Licochalcone A . Positive_regulation IKBKB TNF 20463356 2301064 By Western blot analysis , we found that rapidly and significantly *increased* phosphorylation of [IKBKB] , MAPK1/3 , and MAPK8/9/10 and that the phosphorylation of these kinases by TNF was reduced significantly by TNFRSF1A neutralizing antibody , but not by TNFRSF1B neutralizing antibody . Positive_regulation IKBKB TNF 20484576 2288709 We describe a new regulatory mechanism for PLK1 : PLK1 negatively regulates induced [IKK] *activation* by inhibiting the ubiquitination of NEMO . Positive_regulation IKBKB TNF 20724805 2306882 The results showed that ruscogenin significantly suppressed p65 phosphorylation , IkappaB-alpha phosphorylation and degradation , and inhibited IkappaB kinase alpha (IKKalpha) and [IKKbeta] activation *induced* by . Positive_regulation IKBKB TNF 21138840 2384296 Conversely , overexpression of spliced XBP1 attenuated *induced* phosphorylation of [IKK] , I?Ba , and NF-?B p65 , accompanied by decreased NF-?B activity and reduced adhesion molecule expression . Positive_regulation IKBKB TNF 21232017 2397648 In fact , it seems that most , if not all , proteins relevant for this process have been identified and extensive biochemical and genetic data are available for the role of these factors in *induced* [IKK] activation . Positive_regulation IKBKB TNF 21924245 2501747 For inhibition of induced [IKK] *activation* , DBA was most active . Positive_regulation IKBKB TNF 22231395 2544703 Western blotting was used to assess the expression of both NF-?B regulated gene products and *induced* activation of p65 , I?Ba , and [IKK] . Positive_regulation IKBKB TNF 22231395 2544707 In addition to inhibition of NF-?B p65 nuclear translocation , the compound also suppressed *induced* phosphorylation of p65 and [IKK] , and the degradation of I?Ba . Positive_regulation IKBKB TNF 23125156 2729384 Pretreatment with GG-52 suppressed *induced* activation of I?B kinase ( [IKK] ) and NF-?B signaling in MKN-45 cells . Positive_regulation IKBKB TNF 23266860 2741455 Inhibition of protein kinase C ( PKC ) -a activity by Go6976 and PKC-a siRNA prevented *induced* [IKK] activity , I?B-a phosphorylation/degradation and NF-?B activation . Positive_regulation IKBKB TNF 23530055 2777445 [IKK] can be *activated* by growth factor stimulation or alpha engagement . Positive_regulation IKBKB TNF 23935096 2840751 Additionally , we find that SK1 is not required for *induced* [IKK] phosphorylation , I?B degradation , nuclear translocation of NF-?B subunits , and transcriptional NF-?B activity . Positive_regulation IKBKB TNF 24345501 2880905 *stimulated* significantly phosphorylation on Ser536 of NF-?B/p65 , Ser473 of Akt at 5-15 min , and activations of [IKK-ß] and ERK at 15-30 min. Diosgenin ( 1 µmol · Positive_regulation IKBKB TNF 9710600 526820 Our studies now demonstrate that HTLV-1 Tax activates the recently identified cellular kinases IkappaB kinase alpha (IKKalpha) and [IKKbeta] , which normally phosphorylate IkappaB alpha on both of its N-terminal regulatory serines in *response* to and interleukin-1 (IL-1) stimulation . Positive_regulation IKBKB TNFSF10 10958661 724876 We found that ectopic expression of the dominant negative mutant RIP , RIP ( 559-671 ) , blocks *induced* [IKK] and JNK activation . Positive_regulation IKBKB TNFSF10 10958661 724880 In addition , we also demonstrated that the TNF receptor associated factor 2 (TRAF2) plays little role in induced [IKK] *activation* although it is required for TRAIL mediated JNK activation . Positive_regulation IKBKB TNFSF10 10958661 724888 These results indicated that the death domain kinase RIP , a key factor in TNF signaling , also plays a pivotal role in *induced* [IKK] and JNK activation . Positive_regulation IKBKB TNFSF10 19372584 2058982 PRMT5 contributed to *induced* activation of [inhibitor of kappaB kinase (IKK)] and nuclear factor-kappaB (NF-kappaB) , leading to induction of several NF-kappaB target genes . Positive_regulation IKBKB TNFSF10 22932446 2706169 On the other hand , kurarinone significantly inhibited induced [IKK] *activation* , I?B degradation and nuclear translocation of NF-?B , as well as effectively suppressed cellular FLICE-inhibitory protein long form ( cFLIPL ) expression . Positive_regulation IKBKE TNF 15939554 1420825 We have found that the [IKKi] expression was constitutive in human chondrocytes from OA cartilage and a human chondrocytic cell line C28/I2 but was *up-regulated* by the inflammatory cytokines or IL-1betain an NFkappaB dependent manner . Positive_regulation IKBKE TNF 15939554 1420826 Over-expression of NFkappaB p65 mimics the *induced* activation of the [IKKi] promoter . Positive_regulation IKBKE TNF 17259348 1691266 Furthermore , we found that *induced* [IKKepsilon] expression is inhibited by an androgen analogue ( R1881 ) in androgen-sensitive prostate cancer cells and that this inhibition correlates with the modulation of IkappaBalpha expression by R1881 . Positive_regulation IKBKE TNF 17328045 1711880 Poly ( I-C ) , lipopolysaccharide , and *activated* phosphorylation of [IKKepsilon] and IRF-3 in FLS . Positive_regulation IKBKE TNF 20507904 2327476 Specification of the NF-kappaB transcriptional response by p65 phosphorylation and *induced* nuclear translocation of [IKK epsilon] . Positive_regulation IKBKG CST6 21182083 2373780 plus IFN-? *activated* the [IKK complex] to induce phosphorylation mediated degradation of p105 , the physiological partner and inhibitor of the MEK kinase , tumor progression locus 2 (Tpl-2) . Positive_regulation IKBKG EPHB2 23563696 2794516 Induction in gastric mucosal prostaglandin and nitric oxide by Helicobacter pylori is dependent on mediated *activation* of [IKK-ß] and cPLA2 : modulatory effect of ghrelin . Positive_regulation IKBKG FAS 20212524 2223118 We validated experimentally that stimulation *resulted* in an interaction of p43-FLIP with the [IKK complex] followed by its activation . Positive_regulation IKBKG IL1B 10391945 626983 However , [IKK] activity was strongly *induced* by TNF-alpha but not by . Positive_regulation IKBKG IL1B 11976320 953960 Furthermore , a dominant negative mutant of Akt abolishes IKKbeta inhibition by CaMKKc and ionomycin , suggesting that Akt acts as a mediator of CaMKK signaling to inhibit *induced* [IKK] activity at an upstream target site . Positive_regulation IKBKG IL1B 15077173 1265812 Short-time inhibition of Hsp90 resulted in impaired [IKK] kinase *activation* by TNFalpha , or phorbolester PMA . Positive_regulation IKBKG IL1B 15304320 1284623 15-Deoxy-delta ( 12,14 ) -prostaglandin J ( 2 ) inhibits *induced* [IKK] enzymatic activity and IkappaBalpha degradation in rat chondrocytes through a PPARgamma independent pathway . Positive_regulation IKBKG IL1B 15550384 1360979 Cleavage and degradation of TNF pathway components TNFR1 , RIP , and Hsp90 were observed in l-mimosine and H ( 2 ) O ( 2 ) treated cells indicating a putative mechanism for selective inhibition of TNF but not *induced* [IKK] activation . Positive_regulation IKBKG IL1B 16354686 1504430 Clearance of both superoxide and H2O2 from within the endosomal compartment significantly abrogated *dependent* [IKK] and NF-kappaB activation . Positive_regulation IKBKG IL1B 17009010 1765509 In this report , we show an enhanced activation of CK2 bound to [IKKgamma] or the p65 subunit of the NF-kappaB in *response* to stimulation of intestinal epithelial cells . Positive_regulation IKBKG IL1B 19854138 2155751 A ubiquitin replacement strategy in human cells reveals distinct mechanisms of [IKK] *activation* by TNFalpha and . Positive_regulation IKBKG IL1B 19854138 2155761 We demonstrate that K63 of ubiquitin and the catalytic activity of Ubc13 , an E2 that catalyzes K63 polyubiquitination , are required for [IKK] *activation* by , but surprisingly , not by TNFalpha . Positive_regulation IKBKG IL1B 20038579 2205270 Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and *induced* [IKK/NF-kappaB] and JNK/AP-1 activation . Positive_regulation IKBKG MAP2K6 16584774 1665820 Together , we interpret these data as demonstrating that the activation caused by loss of Gimap5 is a cell intrinsic phenomenon caused , in part , by a dependent *activation* of [IKK] . Positive_regulation IKBKG MAP2K6 24466036 2907716 In addition , activation of NF?B via the MAPK pathway is regulated through *induced* activation of [IKK] . Positive_regulation IKBKG TGM2 16987813 1640587 Recently we reported that *activates* nuclear factor-kappaB (NF-kappaB) [independently of I-kappaB kinase (IKK)] activation , by inducing cross linking and protein polymer formation of inhibitor of nuclear factor-kappaBalpha ( I-kappaBalpha ) . Positive_regulation IKBKG TLR7 22473004 2589067 NLRC5 ablation reduces MHC class I expression , and enhances [IKK] and IRF3 phosphorylation in *response* to stimulation or viral infection . Positive_regulation IKBKG TNF 10195894 604046 In mammalian cells , phosphorylation of two sites at the activation loop of IKKbeta was essential for *activation* of [IKK] by and interleukin-1 . Positive_regulation IKBKG TNF 10384145 624797 [IKK] activity in both RA and osteoarthritis FLS was strongly *induced* by and IL-1 in a concentration dependent manner . Positive_regulation IKBKG TNF 10391945 626982 However , [IKK] activity was strongly *induced* by but not by IL-1beta . Positive_regulation IKBKG TNF 10553091 565541 This study shows that the sesquiterpene lactone parthenolide inhibits a common step in NF-kappa B activation by preventing the *induced* [induction of I kappa B kinase (IKK)] and IKK beta , without affecting the activation of p38 and c-Jun N-terminal kinase . Positive_regulation IKBKG TNF 10820281 694440 Auranofin also blocked [IKK] activation *induced* by and PMA/ionomycin , suggesting that the target of auranofin action is common among these diverse signal pathways . Positive_regulation IKBKG TNF 10946303 722957 [IKK] activity was *stimulated* by both and TPA , and these effects were inhibited by staurosporine or herbimycin . Positive_regulation IKBKG TNF 11096064 802171 Thus , OFF inhibits *induced* [IKK] activation , leading to a decrease in phosphorylation and degradation of inhibitory IkappaBalpha , which in turn results in the decrease of TNF-alpha induced NF-kappaB activation and potentially the transcription of target genes . Positive_regulation IKBKG TNF 11179444 784699 [IKK] activity was *stimulated* by either or C2-ceramide , and these effects were inhibited by PD98059 or SB203580 . Positive_regulation IKBKG TNF 11356844 834421 Activation of phosphatidylinositol (PI) 3-kinase/Akt signaling by *activates* [IKK] and NF-kappaB . Positive_regulation IKBKG TNF 11359906 816587 The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2 dependent [IKK] recruitment to tumor necrosis factor (TNF) receptor 1 in *response* to . Positive_regulation IKBKG TNF 11359906 816593 In *response* to the proinflammatory cytokine , [IKK] is activated after being recruited to the TNF receptor 1 (TNF-R1) complex via TNF receptor associated factor 2 (TRAF2) . Positive_regulation IKBKG TNF 11359906 816601 Importantly , IKKgamma is not essential for *induced* [IKK] recruitment to TNF-R1 , as this occurs efficiently in IKKgamma-deficient cells . Positive_regulation IKBKG TNF 11359906 816603 Using TRAF2 ( -/- ) cells , we demonstrated that the *induced* interaction between [IKKgamma] and the death domain kinase RIP is TRAF2 dependent and that one possible function of this interaction is to stabilize the IKK complex when it interacts with TRAF2 . Positive_regulation IKBKG TNF 11429546 831658 The molecular mechanism that underlies [IKK] activation in *response* to is still unknown . Positive_regulation IKBKG TNF 11479295 860527 Since oxidants have been implicated in the regulation of NF-kappaB , the focus of the present study was the *activation* of [IKK] by in the presence or absence of hydrogen peroxide ( H ( 2 ) O ( 2 ) ) . Positive_regulation IKBKG TNF 11479295 860545 In contrast , *induced* [IKK] activity rapidly and transiently resulting in IkappaBalpha degradation and NF-kappaB activation . Positive_regulation IKBKG TNF 11479295 860548 Importantly , in the presence of H ( 2 ) O ( 2 ) , the ability of to *induce* [IKK] activity was markedly decreased and resulted in prevention of IkappaBalpha degradation and NF-kappaB activation . Positive_regulation IKBKG TNF 11483407 844327 [IKK] activity was *stimulated* by both and TPA , and these effects were inhibited by Ro 31-8220 or tyrphostin 23 . Positive_regulation IKBKG TNF 11799112 922271 PTEN failed to block induced [IKK] *activation* , IkappaBalpha degradation , p105 processing , p65 ( RelA ) nuclear translocation , and DNA binding of NF-kappaB . Positive_regulation IKBKG TNF 11864612 917605 induced recruitment and *activation* of the [IKK complex] require Cdc37 and Hsp90 . Positive_regulation IKBKG TNF 11864612 917625 Geldanamycin ( GA ) , an antitumor agent that disrupts the formation of this heterocomplex , prevents *induced* activation of [IKK] and NF-kappaB . Positive_regulation IKBKG TNF 11954826 930702 Hyperoxia alone did not induce IkappaB kinase (IKK) activity , but significantly prolonged mediated *activation* of [IKK] activity . Positive_regulation IKBKG TNF 11967992 938074 Binding of to its receptor *activates* [IKK complex] , which leads to inducement of NF-kappaB activity . Positive_regulation IKBKG TNF 12023051 943494 stimulation *increased* [IKK] activity within 10 min , and then IKK activity decreased gradually within 30 min in HeLa cells . Positive_regulation IKBKG TNF 12121873 965123 mediated [IKK] *activation* leads to IkappaBalpha and IkappaBbeta degradation . Positive_regulation IKBKG TNF 12181188 977499 In conclusion , Fe2+ serves as a direct agonist to activate [IKK] , NF-kappaB , and TNF-alpha promoter activity and to *induce* the release of protein by cultured Kupffer cells in a redox status dependent manner . Positive_regulation IKBKG TNF 12192055 980846 Substitution of two leucines within a C-terminal leucine zipper motif markedly reduced [IKK] *activation* by and IL-1 . Positive_regulation IKBKG TNF 12192055 980852 Another point mutation resulting in a cysteine-to-serine substitution within the putative Zn finger motif affected [IKK] *activation* by but not by IL-1 . Positive_regulation IKBKG TNF 12692090 1093273 Only at high concentrations , cPG enhanced TNF-alpha induced cell death and inhibited induced [IkappaB-alpha kinase (IKK)] *activation* , IkappaB-alpha degradation , and NF-kappaB/p65 translocation , while promoting AP-1/c-jun phosphorylation . Positive_regulation IKBKG TNF 12842894 1134794 induced [IKK] phosphorylation of NF-kappaB p65 on serine 536 is *mediated* through the TRAF2 , TRAF5 , and TAK1 signaling pathway . Positive_regulation IKBKG TNF 12867425 1141853 Mutations of the zinc finger are found in patients with hypohidrotic ectodermal dysplasia with immunodeficiency ( HED-ID ) and lead to the impairment of *stimulated* [IKK] phosphorylation and activation . Positive_regulation IKBKG TNF 12867425 1141859 Thus , the ubiquitination of NEMO mediated by c-IAP1 likely plays an important role in the *activation* of [IKK] by . Positive_regulation IKBKG TNF 12934647 1132834 IL-1beta and can *induce* extracellular signal regulated kinase ( ERK ) , [IKK] , IkappaB degradation and NF-kappaB activation . Positive_regulation IKBKG TNF 12939259 1157879 However , expression of the adaptor protein RIP , which is essential for [IKK] *activation* by , was decreased in cells exposed to H2O2 , and its chaperone Hsp90 was cleaved . Positive_regulation IKBKG TNF 14764716 1207364 The *activation* of the [I-kappaB kinase (IKK)] complex by or LPS stimulates phosphorylation and degradation of I-kappaBalpha , leading to the nuclear translocation of NF-kappaB . Positive_regulation IKBKG TNF 15106733 1240547 plus IFN-gamma can *induce* extracellular signal regulated kinase ( ERK ) , [IKK] , IkappaB degradation and NF-kappaB activation . Positive_regulation IKBKG TNF 15175328 1273490 *induced* [Ikk] and p38 MAP kinase activation is normal , and the Rip1D138N cells are resistant to TNF-alpha induced cell death , indicating that the kinase activity of Rip1 is not required to mediate its antiapoptotic functions . Positive_regulation IKBKG TNF 15302572 1283881 induced *activation* of [IKK] was suppressed by HS in human bronchial epithelial cells , and this was associated with the absence of IKK in the immunoprecipitates . Positive_regulation IKBKG TNF 15302572 1283884 Overexpression of NIK resumed *induced* activation of [IKK] in thermotolerant cells . Positive_regulation IKBKG TNF 15310755 1303552 At the same time , the binding of AIP1 to TRAF2 inhibits *induced* [IKK-NF-kappaB] signaling . Positive_regulation IKBKG TNF 15550384 1360974 Here we show that l-mimosine , a toxic non-protein amino acid that has been shown to reduce serum TNFalpha levels and affect inflammatory responses , specifically inhibits *induced* [IKK] but not JNK in a cell type-specific manner . Positive_regulation IKBKG TNF 15710601 1395744 Evodiamine also inhibited *induced* Akt activation and its association with [IKK] . Positive_regulation IKBKG TNF 16166517 1456571 Although *induced* [IKK] activity was rapidly attenuated by negative feedback , lipopolysaccharide (LPS) signaling and LPS-specific gene expression programs were dependent on a cytokine mediated positive feedback mechanism . Positive_regulation IKBKG TNF 16246929 1471542 We found that both and LPS *activated* the [I-kappa B kinase complex (IKK)] in DPSCs to induce the phosphorylation and degradation of IkappaBalpha , resulting in the nuclear translocation of NF-kappaB . Positive_regulation IKBKG TNF 16490171 1528605 NAC can inhibit the processes upstream of [IKK] activation *induced* by , which results in the decline of NF-kappaB activity . Positive_regulation IKBKG TNF 16603398 1550700 *Activation* of [IKK] by requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO . Positive_regulation IKBKG TNF 16611882 1545338 Similarly , IKKgamma-delta mediates [IKK] kinase activity and downstream NF-kappaB dependent transcription in *response* to and the NF-kappaB inducing kinase-IKKalpha signaling pathway . Positive_regulation IKBKG TNF 16723255 1570413 *induces* chromosomal abnormalities independent of ROS through [IKK] , JNK , p38 and caspase pathways . Positive_regulation IKBKG TNF 16774932 1672082 The use of Ro-318220 and GO-6983 , general PKC inhibitors as well as MG-132 , a proteasome-specific inhibitor , abrogated PMA induced degradation of IKK-gamma and recovered the *activation* of [IKK] by , suggesting that IKK complex is predominantly degraded by the proteasome pathway in a PKC dependent manner . Positive_regulation IKBKG TNF 16872805 1672443 Ad.IKKbeta+/- treatment completely inhibited *stimulated* [IKK] kinase activity , IkappaB alpha degradation and NFkappaB DNA binding in addition to completely blocking TNFalpha stimulated ICAM-1 and VCAM-1 expression . Positive_regulation IKBKG TNF 16916935 1608533 Conversely , GRX1 knockdown sensitizes cells to oxidative inactivation of IKK-beta and dampens *induced* [IKK] and NF-kappaB activation . Positive_regulation IKBKG TNF 17079781 1708984 Nox1 expression and activation inhibited *induced* [inhibitor of kappaB kinase (IKK)] , and NF-kappaB while promoting JNK activation and cell death . Positive_regulation IKBKG TNF 17095620 1693151 SDX-308 effectively suppressed *induced* [IKK-gamma] and IkappaB-alpha phosphorylation and degradation and subsequent NF-kappaB activation in human multiple myeloma cells . Positive_regulation IKBKG TNF 17110449 1732124 Recent studies indicate that *induced* [IKK] activation requires activation of TAK1 , and we indeed found that celastrol inhibited the TAK1 induced NF-kappaB activation . Positive_regulation IKBKG TNF 17158449 1694239 A green fluorescent protein fusion protein containing the last 100 residues of TAK1 ( TAK1-C100 ) abolished the interaction of endogenous TAB2/TAB3 with TAK1 , the phosphorylation of TAK1 , and prevented the activation of [IKK] and MAPK *induced* by IL-1 , , and RANKL . Positive_regulation IKBKG TNF 17240450 1696456 Mechanistically , a non-radioactive IkappaB kinases (IKK) assay using immunoprecipitated IKKs protein demonstrated that magnolol inhibited both intrinsic and *stimulated* [IKK] activity , thus suggesting a critical role of magnolol in abrogating the phosphorylation and degradation of IkappaBalpha . Positive_regulation IKBKG TNF 17244613 1710250 Our results therefore demonstrate that NEMO and IKKalpha can form a functional [IKK complex] that activates the classical NF-kappaB pathway in *response* to IL-1 but not . Positive_regulation IKBKG TNF 17544371 1751874 Stable expression of TRIP or a RING mutant did not affect [IKK] activation *induced* by or IL-1 and had no affect on TNF induced apoptosis . Positive_regulation IKBKG TNF 17690092 1800499 With moderate GSH depletion ( approximately 50 % ) , the down-regulation is IkappaB kinase (IKK) independent and likely acts on NF-kappaB transcriptional activity because *induced* [IKK] activation , IkappaBalpha phosphorylation and degradation , NF-kappaB nuclear translocation , NF-kappaB DNA binding in vitro , and NF-kappaB subunit RelA ( p65 ) recruitment to kappaB sites of target gene promoters all appear unaltered . Positive_regulation IKBKG TNF 18037881 1832655 Studies in non-malignant epithelial cells show that MUC1 is recruited to the TNF-R1 complex and interacts with [IKKbeta-IKKgamma] in *response* to stimulation . Positive_regulation IKBKG TNF 18644347 1947740 however , Celecoxib had no effect on induced [IKK] *activation* and degradation of IkappaBalpha and IkappaBbeta , suggesting that it inhibited NF-kappaB activation via suppressing downstream of IKK activation and IkappaBs degradation . Positive_regulation IKBKG TNF 18957422 2001135 Expressing a constitutively active Plk1 in mammalian cells reduced *induced* [IKK] activation , resulting in decreased phosphorylation of endogenous IkappaBalpha and reduced NF-kappaB activation . Positive_regulation IKBKG TNF 18957422 2001140 To activate endogenous Plk1 , cells were treated with nocodazole , which reduced *induced* [IKK] activation , and increased the phosphorylation of gammaBD . Positive_regulation IKBKG TNF 18957422 2001145 Knocking down Plk1 in mammalian cells restored *induced* [IKK] activation in nocodazole treated cells . Positive_regulation IKBKG TNF 18957422 2001152 Moreover , we identify Plk1 as a gammaBD kinase , which negatively regulates induced [IKK] *activation* and cyclin D1 expression , thereby affecting cell cycle regulation . Positive_regulation IKBKG TNF 18981220 2015202 These results unveil a new , finely tuned mechanism for induced [IKK] *activation* modulated by TRAF2 phosphorylation and suggest that TRAF2 phosphorylation contributes to elevated levels of basal NF-kappaB activity in certain human cancers . Positive_regulation IKBKG TNF 19010928 1991635 Therefore , inhibition of *induced* [IKK] activity with specific IKK inhibitor represents an attractive strategy to treat cancer patients . Positive_regulation IKBKG TNF 19010928 1991644 This study reveals IKI-1 as a potent small molecule inhibitor of IKKalpha and IKKbeta , which effectively blocked mediated [IKK] *activation* and subsequent NF-kappaB activity . Positive_regulation IKBKG TNF 19091594 2031056 Moreover , the reintroduction of exogenous TRAF6 into TRAF6-deficient MEFs clearly suppressed *induced* [IKK] activation , NF-kappaB activation and subsequent cytokine expression . Positive_regulation IKBKG TNF 19091594 2031061 In contrast , both the deletion mutant ( DeltaN ) and the point mutant ( C70A ) of TRAF6 , which is defective in its ubiquitin ligase activity , failed to repress *induced* [IKK] activation , NF-kappaB activation and cytokine production . Positive_regulation IKBKG TNF 19181934 2043863 Inhibition of ERK 1/2 MAPK with PD98059 attenuated the protective role of IL-10 against *induced* activation of [IKK] and NF kappaB as well as cardiomyocyte apoptosis . Positive_regulation IKBKG TNF 19336568 2056511 Although many serine/threonine kinases have been implicated in *induced* [IKK] activation and NF-kappaB dependent gene expression , most of them do not directly activate IKK . Positive_regulation IKBKG TNF 19336568 2056516 These results reveal a new level of complexity in *induced* [IKK] activation modulated by TRAF2 phosphorylation and suggest that TRAF2 phosphorylation is one of the events that are responsible for elevated basal NF-kappaB activity in certain human cancers . Positive_regulation IKBKG TNF 19409903 2082511 TRAF2 suppresses basal IKK activity in resting cells and can *activate* [IKK] in TRAF2 and TRAF5 double knockout cells . Positive_regulation IKBKG TNF 19409903 2082518 Although TNFalpha induced receptor interacting protein 1 ubiquitination is indeed impaired in T2/5 DKO cells , stimulation further *increases* [IKK] activity in these cells , resulting in significantly elevated expression of NF-kappaB target genes to a level higher than that in wild-type cells . Positive_regulation IKBKG TNF 19409903 2082521 Inhibition of NIK in T2/5 DKO cells attenuates basal IKK activity and restores robust *induced* [IKK] activation to a level comparable with that seen in wild-type cells . Positive_regulation IKBKG TNF 19409903 2082524 This suggests that can *activate* [IKK] in the absence of TRAF2 and TRAF5 expression and receptor interacting protein 1 ubiquitination . Positive_regulation IKBKG TNF 19591457 2122802 TPCK inhibited *induced* [IKK] activation and directly blocked IKK activity in vitro . Positive_regulation IKBKG TNF 19592502 2137142 In contrast , a structurally related compound , echinatin , failed to inhibit *induced* [IKK] activation and NF-kappaB activation , suggesting that the 1,1-dimethy-2-propenyl group in licochalcone A is important for the inhibition of NF-kappaB . Positive_regulation IKBKG TNF 19854138 2155750 A ubiquitin replacement strategy in human cells reveals distinct mechanisms of [IKK] *activation* by and IL-1beta . Positive_regulation IKBKG TNF 19854138 2155759 We demonstrate that K63 of ubiquitin and the catalytic activity of Ubc13 , an E2 that catalyzes K63 polyubiquitination , are required for [IKK] *activation* by IL-1beta , but surprisingly , not by . Positive_regulation IKBKG TNF 19854138 2155772 We further show that [IKK] *activation* by requires Ubc5 , which functions with the E3 cIAP1 to catalyze polyubiquitination of RIP1 not restricted to K63 of ubiquitin . Positive_regulation IKBKG TNF 19877072 2160723 In sharp contrast , DEX did not affect *induced* [IKK] phosphorylation , IkappaBalpha degradation , p65 nuclear translocation , or MAPK activation in RA FLS . Positive_regulation IKBKG TNF 20064526 2205521 The TRAF2 RING domain mediated polyubiquitination of RIP1 is believed to be essential for TNFalpha induced IKK activation , and the RING-domain deleted TRAF2 ( TRAF2-DeltaR ) has been widely used as a dominant negative in transient overexpression systems to block *induced* JNK and [IKK] activation . Positive_regulation IKBKG TNF 20064526 2205526 Here , we report that stable expression of TRAF2-DeltaR at a physiological level in TRAF2 and TRAF5 double knockout ( TRAF2/5 DKO ) cells almost completely restores normal *induced* [IKK] activation , but not RIP1 polyubiquitination . Positive_regulation IKBKG TNF 20064526 2205530 ( ii ) RIP1 polyubiquitination is not essential for *induced* [IKK activation; and (iii)] prolonged JNK activation has no obligate role in TNFalpha induced cell death . Positive_regulation IKBKG TNF 20153843 2236128 Whereas Licochalcone A potently inhibited induced [IKK] *activation* , IkappaBalpha degradation , nuclear localization of NF-kappaB and its DNA binding activity , no inhibitory effect was observed by reduced Licochalcone A . Positive_regulation IKBKG TNF 20484576 2288711 We describe a new regulatory mechanism for PLK1 : PLK1 negatively regulates induced [IKK] *activation* by inhibiting the ubiquitination of NEMO . Positive_regulation IKBKG TNF 21138840 2384298 Conversely , overexpression of spliced XBP1 attenuated *induced* phosphorylation of [IKK] , I?Ba , and NF-?B p65 , accompanied by decreased NF-?B activity and reduced adhesion molecule expression . Positive_regulation IKBKG TNF 21232017 2397649 In fact , it seems that most , if not all , proteins relevant for this process have been identified and extensive biochemical and genetic data are available for the role of these factors in induced [IKK] *activation* . Positive_regulation IKBKG TNF 21924245 2501748 For inhibition of *induced* [IKK] activation , DBA was most active . Positive_regulation IKBKG TNF 22231395 2544704 Western blotting was used to assess the expression of both NF-?B regulated gene products and induced *activation* of p65 , I?Ba , and [IKK] . Positive_regulation IKBKG TNF 22231395 2544708 In addition to inhibition of NF-?B p65 nuclear translocation , the compound also suppressed *induced* phosphorylation of p65 and [IKK] , and the degradation of I?Ba . Positive_regulation IKBKG TNF 23032186 2681075 Both A20 and ZF7 can form a complex with NEMO and LUBAC , and are able to prevent the *induced* binding of [NEMO] to LUBAC . Positive_regulation IKBKG TNF 23032186 2681077 We thus propose a model in which A20 inhibits TNF- and LUBAC induced NF-?B signalling by binding to linear polyubiquitin chains via its seventh zinc finger , which prevents the *induced* interaction between LUBAC and [NEMO] . Positive_regulation IKBKG TNF 23125156 2729385 Pretreatment with GG-52 suppressed *induced* activation of I?B kinase ( [IKK] ) and NF-?B signaling in MKN-45 cells . Positive_regulation IKBKG TNF 23266860 2741456 Inhibition of protein kinase C ( PKC ) -a activity by Go6976 and PKC-a siRNA prevented *induced* [IKK] activity , I?B-a phosphorylation/degradation and NF-?B activation . Positive_regulation IKBKG TNF 23530055 2777446 [IKK] can be *activated* by growth factor stimulation or alpha engagement . Positive_regulation IKBKG TNF 23935096 2840753 Additionally , we find that SK1 is not required for *induced* [IKK] phosphorylation , I?B degradation , nuclear translocation of NF-?B subunits , and transcriptional NF-?B activity . Positive_regulation IKBKG TNF 24345501 2880910 *stimulated* significantly phosphorylation on Ser536 of NF-?B/p65 , Ser473 of Akt at 5-15 min , and activations of [IKK-ß] and ERK at 15-30 min. Diosgenin ( 1 µmol · Positive_regulation IKBKG TNFSF10 10958661 724877 We found that ectopic expression of the dominant negative mutant RIP , RIP ( 559-671 ) , blocks *induced* [IKK] and JNK activation . Positive_regulation IKBKG TNFSF10 10958661 724882 In addition , we also demonstrated that the TNF receptor associated factor 2 (TRAF2) plays little role in induced [IKK] *activation* although it is required for TRAIL mediated JNK activation . Positive_regulation IKBKG TNFSF10 10958661 724889 These results indicated that the death domain kinase RIP , a key factor in TNF signaling , also plays a pivotal role in *induced* [IKK] and JNK activation . Positive_regulation IKBKG TNFSF10 19372584 2058984 PRMT5 contributed to *induced* activation of [inhibitor of kappaB kinase (IKK)] and nuclear factor-kappaB (NF-kappaB) , leading to induction of several NF-kappaB target genes . Positive_regulation IKBKG TNFSF10 22932446 2706170 On the other hand , kurarinone significantly inhibited *induced* [IKK] activation , I?B degradation and nuclear translocation of NF-?B , as well as effectively suppressed cellular FLICE-inhibitory protein long form ( cFLIPL ) expression . Positive_regulation IL10 ABCG2 20846001 2375394 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL10 ARSA 21584653 2531914 Moreover , *increased* the production of the anti-inflammatory cytokines transforming growth factor beta-1 and [interleukin-10] in neuron-glia cultures after stimulation with LPS . Positive_regulation IL10 CCL17 22057112 2540313 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL10 CD14 10417128 631456 The objective of the present study was to investigate whether the production of tumor necrosis factor alpha (TNF) and [interleukin-10 (IL-10)] by human monocytes stimulated by intact heat killed or live Haemophilus influenzae or Streptococcus pneumoniae is *mediated* by . Positive_regulation IL10 CD14 15937058 1427473 Taken together , HIV-1 binding to ( + ) monocytes can *induce* CD4 independent [IL-10] production at both mRNA and protein levels . Positive_regulation IL10 CD14 20946675 2337943 The activation of , TLR4 , and TLR2 by mmLDL *induces* IL-1ß , IL-6 , and [IL-10] secretion in human monocytes and macrophages . Positive_regulation IL10 CD14 7520002 266257 This was functional in that lipopolysaccharide stimulation *induced* interleukin (IL)-6 and [IL-10] in clones 1 and 2 but not in clone 3 . Positive_regulation IL10 CEACAM6 23554642 2367180 In the presence of IFN-? , significantly *promoted* IL-6 , [IL-10] and PGE2 secretion from RAW 264.7 cells . Positive_regulation IL10 CEACAM6 23554642 2367181 can significantly suppress IFN-? induced MHC II expression and significantly *promote* IL-6 , [IL-10] and PGE2 secretion from RAW 264.7 cells compared with UVACA . Positive_regulation IL10 DAPK1 24220855 2897410 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL10 EPHB2 11971021 933498 Studies using rIL-10 and IL-10 gene-deficient mice demonstrated that the inhibitory effect of ERK on CpG DNA mediated IL-12 production is indirect , due to the *role* of in mediating [IL-10] production . Positive_regulation IL10 EPHB2 12609986 1085289 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL10 EPHB2 12797541 1098689 Using highly specific inhibitors of p38 ( SB203580 ) and of MAPK kinase-1 ( U0126 and PD98059 ) , we found that both p38 and ERK were essential for M. tuberculosis H37Rv induced TNF-alpha production , whereas activation of the p38 pathway , but not that of , was *essential* for M. tuberculosis H37Rv induced [IL-10] production . Positive_regulation IL10 EPHB2 12828555 1104987 In addition , inhibition of by PD98059 significantly *suppressed* [IL-10] and increased the IL-12 production . Positive_regulation IL10 EPHB2 12913253 1129636 In addition , [IL-10] *induced* tyrosine (Tyr) phosphorylation of , as well as serine ( Ser ) and Tyr phosphorylation of STAT-3 . Positive_regulation IL10 EPHB2 15972681 1424219 The inhibition of either or p38 *prevented* [IL-10] induction , indicating that both MAPKs were required for IL-10 synthesis . Positive_regulation IL10 EPHB2 16160917 1456081 The analysis of cytokine production using specific inhibitors of the MAPK pathway revealed that both p38 and ERK activation are essential for PPD induced TNF-alpha production , whereas p38 , but not , activation is *essential* for [IL-10] secretion . Positive_regulation IL10 EPHB2 16210601 1464418 Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through mediated [IL-10] *induction* . Positive_regulation IL10 EPHB2 16824602 1666071 These results suggest that PI3K positively and negatively regulates the production of CpG-ODN induced IL-10 and IL-12 p70 , respectively , and negatively regulates IL-12 p70 production in macrophages through mediated [IL-10] *induction* . Positive_regulation IL10 EPHB2 17458858 1743180 Syk dependent activation *regulates* IL-2 and [IL-10] production by DC stimulated with zymosan . Positive_regulation IL10 EPHB2 18310510 1904075 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL10 EPHB2 19646904 2125352 [Interleukin-10] production by Th1 cells *requires* interleukin-12 induced STAT4 transcription factor and MAP kinase activation by high antigen dose . Positive_regulation IL10 EPHB2 20537708 2279367 Inhibition of *down-regulated* [IL-10] production and restored DC stimulatory capacity , showing the importance of this pathway in the DC modulation . Positive_regulation IL10 EPHB2 23667643 2785005 Further , overexpression *increased* [IL-10] promoter activity stimulated by wild-type human GR but not by its mutant defective in serine 203 , whereas ERK knockdown abolished NDV/DEX cooperation on IL-10 mRNA and phosphorylation of the mouse GR at serine 213 . Positive_regulation IL10 EPHB2 24191131 2864321 Enhanced signaling *contributed* to enhanced [IL-10] production , and suppression of NF- ? B signaling contributed to the low production of TNF- a . Positive_regulation IL10 EPHB2 24737107 2943070 We demonstrate that the activation of STAT3 and is *required* for TLR induced [IL-10] production by B cells , since inhibition of STAT3 or ERK activation abrogates TLR induced IL-10 production . Positive_regulation IL10 F3 7635444 317246 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL10 FAS 11069082 747697 Here we demonstrate that receptor engagement *results* in the induction of the [IL-10] gene in monocytes , but not in lymphocytes or dendritic cells . Positive_regulation IL10 FAS 14530312 1149174 Cross linking of with the agonistic Ab , CH-11 , triggered apoptosis and *enhanced* the expression of [IL-10] in Jurkat cells at the transcriptional and translational levels . Positive_regulation IL10 FAS 24431281 2901344 Taken together , our findings indicate that impaired signaling *results* in enhanced expression of antiinflammatory [IL-10] and reduced expression of gp96 , and these effects are associated with accelerated resolution of inflammation during the chronic phase of arthritis . Positive_regulation IL10 HRH1 15021962 1221741 Depletion of the *resulted* in decreases in the release of IL-2 and [IL-10] from both CD4+ and CD8+ cells and increases in the release of IL-4 from CD4+ T cells and IFN-gamma from CD8+ cells . Positive_regulation IL10 IL1B 11069732 747856 At the doses of 10 and 100 U/ml , IFN gamma markedly inhibited the constitutive and *stimulated* IL-8 , [IL-10] and stromelysin productions . Positive_regulation IL10 IL1B 11437211 832736 Low magnitude of tensile strain inhibits dependent induction of pro-inflammatory cytokines and *induces* synthesis of [IL-10] in human periodontal ligament cells in vitro . Positive_regulation IL10 IL1B 11437211 832739 Additionally , as an anti-inflammatory signal , TENS induces [IL-10] synthesis in the *presence* and absence of . Positive_regulation IL10 IL1B 11570587 864278 Our studies on the regulation of IL-10 secretion in OVCAR-3 revealed that ( 1 ) proinflammatory stimuli IL-1beta and TNF-alpha , but not LPS , enhance IL-10 secretion , ( 2 ) IL-6 has no influence on the release of IL-10 , ( 3 ) prostaglandin E2 influences neither the spontaneous nor the TNF-alpha- or *stimulated* [IL-10] production and ( 4 ) interferon-gamma inhibits IL-10 secretion . Positive_regulation IL10 IL1B 12466379 1022357 , but not gonadal steroid hormones , was able to directly *increase* endometrial/decidual [IL-10] production . Positive_regulation IL10 IL1B 12548226 1051365 An inverse relationship was noted between amniotic fluid [interleukin-10] concentrations and *induced* uterine activity ( r = -0.74 , P < .05 ) . Positive_regulation IL10 IL1B 12569227 1057236 Plasma interleukin (IL)-6 , IL-8 , [IL-10] , granulocyte colony stimulating factor ( G-CSF ) , macrophage CSF (M-CSF) , and monocyte chemotactic protein 1 (MCP-1) increased significantly after the race , and urine , IL-6 , G-CSF , M-CSF , and MCP-1 *increased* significantly . Positive_regulation IL10 IL1B 12711326 1083267 To investigate whether TGZ acts by affecting the ICAM-1/LFA-1 pathway and/or the Th1/Th2 cytokine balance in NOD mice , we analysed the *induced* ICAM-1 expression on islet-cells and the LFA-1 , CD25 , IL-2 , IFN-gamma , IL-4 , and [IL-10] expression on splenocytes . Positive_regulation IL10 IL1B 14617515 1200634 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL10 IL1B 15103492 1258350 Our results showed that *induced* an 11-fold increase in [IL-10] production in pediatric PMs ( 659+/-103 vs. 60+/-25 control , P < 0.05 ) . Positive_regulation IL10 IL1B 15103492 1258359 Furthermore , pediatric PMs had an 11-fold increase in *induced* [IL-10] production , while adult PMs did not produce IL-10 . Positive_regulation IL10 IL1B 16375968 1547123 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL10 IL1B 16499573 1528907 When infected HeLa cells were co-cultured with THP-1 cells , IL-6 and IL-8 secretion was sustained , expression followed a bell shaped curve and [IL-10] , IL-12p70 and TNF-alpha synthesis was down *regulated* . Positive_regulation IL10 IL1B 17022949 1641522 Relative to saline administration , increased IL1beta , TNFalpha and IL6 mRNAs in the nucleus tractus solitarius (NTS) , hypothalamus , hippocampus and somatosensory cortex ( SSctx ) , but did not *induce* any changes in [IL10] . Positive_regulation IL10 IL1B 17484771 1778191 LPS induced production of tumour necrosis factor-alpha (TNF-alpha) , interleukin-6 (IL-6) , [IL-10] and interferon-gamma-inducible protein-10 (IP-10); SA *induced* TNF-alpha , and production ; Positive_regulation IL10 IL1B 20114085 2219601 Amelioration of arthritis in B7-1 deficient mice was accompanied by a lower local production of and IL-18 , and *increase* in IL-4 and [IL-10] secretion . Positive_regulation IL10 IL1B 8258695 238787 These studies concerning IL-10 mRNA induction by TNF-alpha were corroborated by studies of IL-10 protein secretion : TNF-alpha alone , but not IL-1 alpha , , or IL-6 *induces* substantial [IL-10] secretion . Positive_regulation IL10 IL1B 8926090 393280 Viable E. chaffeensis organisms were not required for IO , IL-8 , and [IL-10] mRNA *induction* , since heat killed E. chaffeensis induced identical time course responses . Positive_regulation IL10 IL1B 9360229 462326 Decidual cells in culture produced [IL-10] in *response* to , but chorion and amnion cells produced no IL-10 protein . Positive_regulation IL10 IL1R2 8387521 218016 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL10 ITGAL 12847222 1108854 Increased resistance of LFA-1-deficient mice to lipopolysaccharide induced shock/liver injury in the presence of TNF-alpha and IL-12 is *mediated* by [IL-10] : a novel role for in the regulation of the proinflammatory and anti-inflammatory cytokine balance . Positive_regulation IL10 JAG1 15749897 1379751 Membrane also *induce* purified macrophages from noninfected individuals to secrete [IL-10] and TNF-alpha , but have no effect on IL-1alpha or IL-12 secretion . Positive_regulation IL10 JAG1 21490151 2422911 In this article , we demonstrate that LT acts as a highly effective adjuvant when administered parenterally , promoting Ag-specific IL-17 , as well as IFN-? , IL-4 , and [IL-10] production in *response* to coadministered . Positive_regulation IL10 JAG1 23630352 2784436 Adoptive transfer of only OX40L ( + ) ( + ) BMDCs *led* to Treg expansion , increased production of IL-4 and [IL-10] , and suppression of EAT in the recipient mice . Positive_regulation IL10 MAP2K6 18401006 1925777 CyaA enhanced LPS induced phosphorylation of p38 MAPK and ERK in DC , and inhibitors of p38 MAPK , , or NF-kappaB *suppressed* [IL-10] production in response to LPS and CyaA . Positive_regulation IL10 MMP28 15667587 1365765 We hypothesized that previously reported defective synthesis of [IL-10] by immunocompetent cells exposed to a uraemic milieu may be *due* to impaired mitochondrial . Positive_regulation IL10 MMP7 15667587 1365780 We hypothesized that previously reported defective synthesis of [IL-10] by immunocompetent cells exposed to a uraemic milieu may be *due* to impaired mitochondrial . Positive_regulation IL10 NT5E 21057730 2344655 *dependent* regulation of interferon aA and [interleukin-10] in the inflamed mucosa . Positive_regulation IL10 PGC 22117073 2535008 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL10 SRGN 16551363 1542054 stimulation *induced* primarily [IL-10] cytokine production , in addition to IFN-gamma , IL-13 and TNF-alpha secretion . Positive_regulation IL10 SRGN 16551363 1542056 *induced* [IL-10] production and induction of Foxp3 were higher in CBMC without , than with maternal atopy ( p = 0.04 , p = 0.049 ) . Positive_regulation IL10 SRGN 16551363 1542062 TLR2 stimulation with *induces* [IL-10] and genes associated with T regulatory cells , influenced by maternal atopy . Positive_regulation IL10 STAT4 18401353 1920315 We determined that much like IFN-gamma , is largely *required* for IL-12 induced [IL-10] . Positive_regulation IL10 STAT4 19646904 2125331 [Interleukin-10] production by Th1 cells *requires* interleukin-12 induced transcription factor and ERK MAP kinase activation by high antigen dose . Positive_regulation IL10 STAT4 7638186 317673 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL10 TLR7 12045249 950113 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL10 TLR7 15998638 1447165 A52R mediated enhancement of *induced* [IL-10] may be important to virulence , given the role of IL-10 in immunoregulation . Positive_regulation IL10 TLR7 16461743 1540895 Moreover , they lack MDP induced enhancement of *mediated* tumor necrosis factor alpha , interleukin (IL)-12 , and [IL-10] production , which is observed in control DC with intact NOD2 . Positive_regulation IL10 TLR7 16461893 1522709 In *response* to signals , MKP-1-deficient macrophages produced 5- to 10-fold higher [IL-10] , which could be blocked by a p38 MAPK inhibitor . Positive_regulation IL10 TLR7 17082638 1643394 Bruton 's tyrosine kinase is required for *induced* [IL-10] production . Positive_regulation IL10 TLR7 17082638 1643406 We demonstrate that Btk is activated by TLR4 in primary macrophages and is required for normal *induced* [IL-10] production in multiple macrophage populations . Positive_regulation IL10 TLR7 17114424 1651398 Macrophages and myeloid dendritic cells , but not plasmacytoid dendritic cells , produce [IL-10] in *response* to MyD88- and TRIF dependent signals , and TLR independent signals . Positive_regulation IL10 TLR7 17238832 1664290 *stimulated* [IL-10] production may regulate DC maturation steps , thereby influencing the ensuing immune responses . Positive_regulation IL10 TLR7 17404311 1722021 However , *induced* production of [IL-10] was increased and that of IFN-gamma-inducible protein decreased by Alum cotreatment . Positive_regulation IL10 TLR7 17579043 1763722 Role of phosphatidylinositol-3 kinase in transcriptional regulation of *induced* IL-12 and [IL-10] by Fc gamma receptor ligation in murine macrophages . Positive_regulation IL10 TLR7 17579043 1763784 This increase was blocked by PI3K inhibitors , wortmannin or LY294002 , as was the effect of FcgammaR ligation on *induced* IL-12 and [IL-10] . Positive_regulation IL10 TLR7 17652449 1793649 *induced* TNF-alpha , IL-1beta , and [IL-10] production is mediated through MyD88 , whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta . Positive_regulation IL10 TLR7 17948265 1819976 Several studies have linked the activation of extracellular signal regulated kinases with [IL-10] *induction* by . Positive_regulation IL10 TLR7 18292228 1878588 Dendritic cells ( DC ) selectively acquire Delta-like 4 expression upon *stimulation* with various ligands and concomitantly induce [IL-10] production by Th1 cells in vitro and in vivo . Positive_regulation IL10 TLR7 18312842 1879298 Toxoplasma profilin is essential for host cell invasion and dependent *induction* of an [interleukin-12] response . Positive_regulation IL10 TLR7 18322186 1881192 Inhibition of p38 suppressed *induced* [IL-10] and PGE ( 2 ) and enhanced IL-12 production in DC . Positive_regulation IL10 TLR7 18424756 1900000 Strikingly , IL-27 strongly suppressed *induced* [IL-10] production in human monocytes . Positive_regulation IL10 TLR7 19265114 2045458 Both TLR7 and TLR8 play a central role in this phenomenon : TLR4 triggering with LPS up-regulates TLR7 expression on human MoDCs from high responders , silencing of either TLR7 or TLR8 mRNAs inhibits cytokine production in LPS plus R848 treated MoDCs , and plasmacytoid DCs constitutively expressing high levels of *induce* the production of [IL-10] , IFN-gamma , and IL-17A by naive T cells when stimulated with R848 alone . Positive_regulation IL10 TLR7 19667062 2132734 Here , we investigated the role of the TPL-2 signaling pathway in *induction* of interferon-beta (IFN-beta) and [interleukin-10 (IL-10)] in these cell types . Positive_regulation IL10 TLR7 20332525 2230798 Peripheral blood mononuclear cells ( PBMCs ) isolated from this patient exhibited enhanced production of IgG4 and [interleukin-10] upon *stimulation* with ligands as compared with those from a healthy control . Positive_regulation IL10 TLR7 20384871 2239990 We found that CD25 ( + ) B cells secreted higher levels of IL-6 , [IL-10] and INFgamma in *response* to different , and were better at presenting alloantigen to CD4 ( + ) T cells . Positive_regulation IL10 TLR7 20625435 2291772 Here we discovered that peritoneal B-1 ( B-1P ) cells produce high levels of [IL-10] upon *stimulation* with several ligands . Positive_regulation IL10 TLR7 20632067 2367991 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in mediated *activation* of caspase 1 and [interleukin-1ß] . Positive_regulation IL10 TLR7 20979991 2365441 stimulation *induced* substantial level of [IL-10] production by WT DCs , but significantly low level of IL-10 production by TNF-a ( -/- ) DCs . Positive_regulation IL10 TLR7 21106540 2389811 C5a controls *induced* [IL-10] and IL-12 production independent of phosphoinositide 3-kinase . Positive_regulation IL10 TLR7 21106540 2389821 Mouse macrophages produce IL-12 and [IL-10] in *response* to ligands such as LPS , CpG , Poly I:C and Malp2 . Positive_regulation IL10 TLR7 21398611 2411912 Mal mediates *induced* activation of CREB and expression of [IL-10] . Positive_regulation IL10 TLR7 21689906 2505134 As a result , IVIg suppresses *induced* production of the proinflammatory IL-6 , but not that of the anti-inflammatory [IL-10] . Positive_regulation IL10 TLR7 21971520 2512673 In marked contrast , TRAF3 ( -/- ) B cells made elevated amounts of TNF and IL-6 protein , as well as [IL-10] and IP-10 mRNA , in *response* to ligands . Positive_regulation IL10 TLR7 22521509 2613489 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL10 TLR7 22556042 2625000 Oxidized LDLs inhibit *induced* [IL-10] production by monocytes : a new aspect of pathogen accelerated atherosclerosis . Positive_regulation IL10 TLR7 22563430 2596168 In particular , HAGGs consistently enhanced the *induced* [IL-10] production in both classically and alternatively polarized macrophages ( M1 and M2 ) . Positive_regulation IL10 TLR7 22685319 2676005 Interestingly , despite expression of TLR mRNA on Kupffer cells , ligation of TLR4 , , and TLR9 *resulted* in a weak induction of [IL-10] , low or undetectable levels of IL-12p40 and TNF , and up-regulation of CD40 on the surface . Positive_regulation IL10 TLR7 22795952 2645450 Even though *induced* TNFa , [IL-10] and IL-6 production , only recombinant TNFa was able to downregulate CD36 . Positive_regulation IL10 TLR7 23074227 2706673 However , Okazaki et al. ( C5a controls *induced* [IL-10] and IL-12 production independent of phosphoinositide 3-kinase . Positive_regulation IL10 TLR7 23080298 2745162 KCs lacking Tpl2 display defects with *induction* of cytokines interleukin (IL)-1ß , [IL-10] , and IL-23 . Positive_regulation IL10 TLR7 23246311 2731993 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL10 TLR7 23616654 2795388 By infecting TLR7-deficient mice with a retroviral pathogen , Friend virus ( FV ) , I determined that potently inhibits retroviral replication during the first 5 days of infection and is *required* for rapid secretion of virus-specific IgM and [interleukin-10 (IL-10)] in response to infection . Positive_regulation IL10 TLR7 23878196 2835412 Additionally , [IL-10] , TGF-ß1 , peroxisome proliferator activated receptor ? , LIGHT ( TNF superfamily 14 ) , and sphingosine kinase-1 were up-regulated , and such M2 polarization was *dependent* on ligation . Positive_regulation IL10 TLR7 23883517 2870755 Macrophages and DCs generated from AMPKa1-deficient mice produced higher levels of proinflammatory cytokines and decreased production of the anti-inflammatory cytokine [IL-10] in *response* to and CD40 stimulation as compared with WT cells . Positive_regulation IL10 TLR7 23968562 2855733 Rapamycin inhibited the ability of both activated and TLR-9 activated PDC to *stimulate* production of IFN-? and [interleukin (IL)-10] by allogeneic T cells . Positive_regulation IL10 TLR7 24737107 2943054 Here , we show that signaling , but not BCR activation or CD40 ligation , *induces* potent production of [IL-10] in human B cells . Positive_regulation IL10 TLR7 24737107 2943065 We demonstrate that the activation of STAT3 and ERK is required for TLR induced IL-10 production by B cells , since inhibition of STAT3 or ERK activation abrogates *induced* [IL-10] production . Positive_regulation IL10 TLR7 24737107 2943077 These results yield insights into the mechanisms by which signaling *regulates* [IL-10] production in B cells and how type I IFN modulates TLR mediated IL-10 production by B cells , therefore providing potential targets to modulate the function of IL-10 producing B cells . Positive_regulation IL10 TLR7 24771857 2937077 At the cellular level , Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower TNF-a and higher [IL-10] in *response* to ligands than did their WT counterparts . Positive_regulation IL10 TNF 10332965 614913 [IL-10] exerted inhibitory effects on both CD40 ligation induced and CD40 ligation plus IFN-gamma *induced* production by ST cells . Positive_regulation IL10 TNF 10417618 631631 Neutralization of tumor necrosis factor-alpha reduced by 54 % the interleukin-10 production that was induced by monocytes binding to cellular fibronectin , indicating that [interleukin-10] induction is at least in part *dependent* upon concomitant autocrine release . Positive_regulation IL10 TNF 11001546 734540 Human recombinant ( 25 ng/mL ) added during the activation culture *resulted* in a two-fold increase in interferon-gamma release ( type 1 response ) and a significant reduction of [interleukin-10] ( type 2 response ) after tumor antigen stimulation . Positive_regulation IL10 TNF 11008105 735746 An early production of by exposed monocytes was *followed* by the production of [IL-10] and a reduced expression of HLA-DR and the costimulatory molecules B7-1 and B7-2 , while other adhesion receptors remained unaffected . Positive_regulation IL10 TNF 11023664 738347 M-CSF primed monocyte [IL-10] production was *dependent* on endogenous and , to a lesser extent , IL-1 , whereas IFN-gamma primed monocytes were partially dependent on endogenous IL-1 . Positive_regulation IL10 TNF 11069082 747698 In contrast , *stimulated* [IL-10] production in dendritic cells but not monocytes . Positive_regulation IL10 TNF 11108135 756677 The anti-inflammatory cytokine [IL-10] is up-regulated in *response* to suggesting a control mechanism of inflammation . Positive_regulation IL10 TNF 11290804 800682 Cycloheximide had no effect on *induced* [IL-10] binding , strongly suggesting the release of a pre existing pool of IL-10R rather than de novo receptor synthesis by PMN . Positive_regulation IL10 TNF 11290804 800683 Furthermore , the kinetics of *induced* up-regulation of [IL-10] binding to PMN ran parallel to the kinetics of the inhibitory effect of IL-10 on the oxidative burst , suggesting a key role of IL-10R mobilization from specific granules to the membranes in optimal regulation of inflammatory responses . Positive_regulation IL10 TNF 11518190 851508 ( ii ) In contrast , *had* no effect on [IL-10] and only a modest effect on IL-1beta and IL-6 levels in these cells . Positive_regulation IL10 TNF 11741746 897691 Similarly , also *caused* a moderate increased expression of different anti-inflammatory cytokines such as IL-9 ( 104 % ) , [IL-10] ( 24 % ) and IL-15 ( 47 % ) . Positive_regulation IL10 TNF 11750868 889867 The pathogenic microorganisms *induced* a dose- and time dependent release of IL-1beta , IL-6 , IL-8 , and [IL-10] , whereas secretion was not elevated . Positive_regulation IL10 TNF 11753547 890126 After a slight decrease in week +1 , significantly *increased* from week +2 and peaked at week +3 , whereas , [IL-10] values started to rise in week +2 and peaked during week +4 . Positive_regulation IL10 TNF 11801671 902592 The underlying mechanism of TNF-alpha suppression could be assigned to LcrV mediated IL ( IL)-10 production , because 1 ) LcrV *induces* [IL-10] release in macrophages , 2 ) anti-IL-10 Ab treatment completely abrogated suppression , and 3 ) TNF-alpha suppression was absent in LcrV treated macrophages of IL-10-deficient (IL-10-/-) mice . Positive_regulation IL10 TNF 11895951 920815 *increased* the production of [IL-10] , as elicited by lipoproteins . Positive_regulation IL10 TNF 11943316 928692 The objectives of this study were to determine interleukin (IL)-1 beta , IL-2 , IL-4 , IL-5 , IL-6 , IL-8 , [IL-10] , interferon (IFN)-gamma and *induction* in bronchoalveolar lavage (BAL) of control horses and horses with heaves both during remission and exacerbation of the disease , and to determine the effect of therapy with inhaled fluticasone propionate on the cytokine profile of horses with heaves . Positive_regulation IL10 TNF 11997699 939516 [IL-10] release was *suppressed* by an inhibitor of p38 MAPK , SB203580 but not by an inhibitor of ERK pathway , PD98059 , whereas both SB203580 and PD98059 inhibited release . Positive_regulation IL10 TNF 11998908 939566 We speculated that is related to demyelination and that [IL-10] is *induced* to modulate TNF-alpha induced inflammation in ADEM . Positive_regulation IL10 TNF 12411792 1010931 Stored allogeneic whole blood resulted in a significant depression ( -61 % ) and [IL-10] *induction* ( +221 % ) . Positive_regulation IL10 TNF 12414777 1011166 During the acute phase , IFN-gamma and *induced* increases in IL-2 , sIL-2R , [IL-10] , and sCD30 levels in serum , which allowed the development of immunity characterized by the nonreactivity of the HBV surface antigen , the onset of antibodies to the HBV surface antigen ( anti-HBs ) , and normal alanine aminotransferase levels during the convalescent phase . Positive_regulation IL10 TNF 12479648 1024075 The reduction in DSS induced inflammation noted with PPARgamma ligand treatment was associated with decreased interferon-gamma and and *increased* interleukin (IL)-4 and [IL- 10] levels as assessed by quantitative reverse transcriptase-polymerase chain reaction . Positive_regulation IL10 TNF 12738469 1087958 L. casei DN-114 056 or E. coli increased [IL-10] release in the *presence* of neutralizing . Positive_regulation IL10 TNF 12956861 1137850 Besides a suppression of the pro-inflammatory cytokines IFN-gamma and , IgG *enhances* the anti-inflammatory cytokine [IL-10] . Positive_regulation IL10 TNF 12974750 1139759 Analysis of mRNA expression of cytokines in the spleen revealed no alterations in , transforming growth factor (TGF)-beta , interleukin (IL)-12 and interferon (IFN)-gamma and *induction* of [IL-10] and IL-4 . Positive_regulation IL10 TNF 1463043 206746 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL10 TNF 14726820 1198269 Increased IFNgamma , , and IL-6 expressions were present , but [IL-10] expression only *increased* in later stages . Positive_regulation IL10 TNF 15034082 1223631 Recombinant IL-6 , but not IL-10 , , and IFN-alpha , *stimulated* the secretion of [IL-10] by colon tumor cells . Positive_regulation IL10 TNF 15220936 1295700 The IFNgamma produced by PMN was biologically active , as demonstrated by its ability to induce synthesis by PMN themselves or to *induce* [IL-10] synthesis by peripheral blood mononuclear cells . Positive_regulation IL10 TNF 15300176 1283631 This dysregulated signaling was associated with attenuated production of , but *increased* production of [interleukin-10] . Positive_regulation IL10 TNF 15319486 1303769 These results show that DEP , through eDEP mediated ROS , *induce* HO-1 expression and [IL-10] production and at the same time inhibit AM production of and IL-12 to dampen the host immune responses . Positive_regulation IL10 TNF 15749027 1379457 We demonstrate here for the first time that the antiinflammatory cytokine [IL-10] is secreted by human WAT explants and that it is *up-regulated* by LPS and in vitro , as well as in obesity in humans ( 2- and 6-fold increase in subcutaneous and visceral WAT , respectively ) and rodents ( 4-fold increase ) . Positive_regulation IL10 TNF 15761496 1397163 This was followed by a significant increase in levels of [IL-10] , whereas IFN-gamma gene upregulation was more transient , and levels of and MIP-1alpha/beta transcripts did not *increase* in either blood or tissues . Positive_regulation IL10 TNF 15809201 1391982 Cultured alveolar macrophages from patients with idiopathic pulmonary fibrosis ( IPF ) show dysregulation of lipopolysaccharide induced and [interleukin-10 (IL-10)] *inductions* . Positive_regulation IL10 TNF 16396246 1494544 By using specific cytokine inhibitors we were able to show that endogenous IL-1 , but not IL-18 and was *required* for IFNgamma and [IL-10] release upon stimulation with A. fumigatus hyphae , whereas conidia induced IFNgamma stimulation is independent of these cytokines . Positive_regulation IL10 TNF 17022949 1641521 Relative to saline administration , IL1beta increased IL1beta , and IL6 mRNAs in the nucleus tractus solitarius (NTS) , hypothalamus , hippocampus and somatosensory cortex ( SSctx ) , but did not *induce* any changes in [IL10] . Positive_regulation IL10 TNF 17022949 1641528 *increased* TNFalpha , IL1beta and [IL10] mRNAs in the NTS , but did not induce any changes in IL-6 mRNA . Positive_regulation IL10 TNF 17082598 1643229 The FcgammaRIIB blockade inhibits GXM induced [IL-10] production and *induces* secretion . Positive_regulation IL10 TNF 17241871 1690654 Molecular protective mechanisms of IL-10 were characterized in *stimulated* [IL-10 receptor (IL-10R)] reconstituted epithelial cells . Positive_regulation IL10 TNF 17444956 1729834 OPN increased CD69 and CD25 expression and enhanced T-cell IFN-gamma and production in a dose dependent fashion with higher levels in CD than in healthy controls ( HC ) , but *induced* a concomitant higher [IL-10] production in HC than CD . Positive_regulation IL10 TNF 17471309 1731989 In the in vitro culture experiments , [IL-10] induced CX3CR1 expression on the surface of monocytes , and *induced* membrane bound FKN as well as soluble FKN expression in synovial fibroblasts . Positive_regulation IL10 TNF 17484771 1778190 LPS induced production of tumour necrosis factor-alpha (TNF-alpha) , interleukin-6 (IL-6) , [IL-10] and interferon-gamma-inducible protein-10 (IP-10); SA *induced* , and IL-1beta production ; Positive_regulation IL10 TNF 17537727 1767284 Short-term treatment of RAW264.7 macrophages with adiponectin increases tumor necrosis factor-alpha (TNF-alpha) expression via ERK1/2 activation and Egr-1 expression : *role* of in adiponectin stimulated [interleukin-10] production . Positive_regulation IL10 TNF 17537727 1767288 this then *contributed* to increased expression of [interleukin-10] , which in turn was required for the development of tolerance to subsequent LPS exposure . Positive_regulation IL10 TNF 17537727 1767295 these increases in in turn *lead* to increased expression of [interleukin-10] and an eventual dampening of LPS mediated cytokine production in macrophages . Positive_regulation IL10 TNF 17565907 1753567 Ctx suppressed secretion by MoDC , but *induced* [IL-10] production . Positive_regulation IL10 TNF 17854477 1795885 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving dependent [interleukin-12] *induction* . Positive_regulation IL10 TNF 18023359 1832155 Stimulation with or TNF-alpha and IL-10 significantly inhibited collagen type II and *increased* [IL-10] and TNF-alpha mRNA expression . Positive_regulation IL10 TNF 18336664 1881647 this then *contributed* to increased expression of [IL-10] . Positive_regulation IL10 TNF 18392950 1938289 Thus , these results lend support to the hypothesis that Hsp70 is actively released from FLSs in response to heat shock or and Hsp70 may be a major paracrine/autocrine *inducer* of [IL-10] production in FLSs via TLR4 . Positive_regulation IL10 TNF 18649083 1954756 This was accompanied by reduced and *increased* [IL-10] and TGF-beta secretion from intestinal and splenic lymphocytes . Positive_regulation IL10 TNF 18793216 2053055 Similar suppression and [IL-10] *induction* by PCERA-1 were observed in macrophages when activated by Toll-like receptor 4 (TLR4) , TLR2 and TLR7 agonists . Positive_regulation IL10 TNF 18793216 2053057 In conclusion , the anti-inflammatory activity of PCERA-1 seems to be mediated by a cell membrane receptor , upstream of cAMP production , and eventually suppression and [IL-10] *induction* . Positive_regulation IL10 TNF 19026560 2001497 [IL-10] overexpression differentially affects cartilage matrix gene expression in *response* to in human articular chondrocytes in vitro . Positive_regulation IL10 TNF 19181914 2033238 Iloprost induced [IL-10] expression , but suppressed CpG oligodeoxynucleotide- ( or imiquimod- ) *induced* and IFN-alpha production in pDCs . Positive_regulation IL10 TNF 19278729 2063561 Synergistic [IL-10] *induction* by S. gordonii and was not observed in TLR-2 ( -/- ) BM-DCs , and TNF was found to cause TLR-2 upregulation , providing at least a partial mechanism for the observed synergy . Positive_regulation IL10 TNF 19410299 2128210 Zymosan *enhanced* dectin-1/TLR2/TLR4 expression and [TNF-alpha/IL-10] production in all of three types of cell , whereas p-beta-glucan increased dectin-1/TLR4 and production in AMs but inhibited IL-10 in mDCs . Positive_regulation IL10 TNF 19769639 2140939 Additionally , [IL-10] was *increased* by 10-fold ( p < 0.001 ) and decreased by 57 % ( p < 0.05 ) when compared with that of the day 185 of pregnancy . Positive_regulation IL10 TNF 19898617 2161706 Maternal protozoan infections was independently associated with reduced infant [IL10] in *response* to PHA and to LPS as well as reduced and IFN-gamma in response to PHA . Positive_regulation IL10 TNF 19922425 2240900 Our results suggest that PCERA-1 activates a G ( s ) protein coupled receptor , leading to elevation of cAMP , which acts via the PKA-CREB pathway to promote suppression and [IL-10] *induction* in LPS stimulated macrophages . Positive_regulation IL10 TNF 20159741 2208563 Tylosin at 500 mg/kg had no effect on or IL1beta production , but it *induced* [IL10] production in healthy mice . Positive_regulation IL10 TNF 20303596 2230526 Our results thus indicate that PKA mediated phosphorylation of CREB promotes suppression and [IL-10] *induction* , whereas the same phosphorylation event initiated by LPS and mediated by MSK1 is non-functional for transcriptional modulation . Positive_regulation IL10 TNF 20587320 2285683 Treatment with astilbin decreases expression but *induces* [IL-10] expression in liver during warm ischemia-reperfusion injury . Positive_regulation IL10 TNF 20734355 2335896 Mechanistically , GMSC treatment mitigated local inflammation *mediated* by a suppressed infiltration of inflammatory cells and production of IL-6 and , and an increased expression of [IL-10] . Positive_regulation IL10 TNF 20937337 2369086 In addition , exogenous could *enhance* [IL-10] secretion from normal monocytes in a dose-response manner . Positive_regulation IL10 TNF 20979991 2365421 The *role* of for [interleukin-10] production by murine dendritic cells . Positive_regulation IL10 TNF 20979991 2365424 In the present study , we examined the *role* of in [interleukin (IL)-10] production by dendritic cells (DCs) using bone-marrow derived DCs from wild type ( WT ) and TNF-a knockout ( TNF-a ( -/- ) ) mice . Positive_regulation IL10 TNF 2113076 135540 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL10 TNF 21265078 2359744 It is established that the level of cytokines IL-1beta , IL-6 , considerably *increases* in patients with acute inflammatory process ( phlegmonous appendicitis ) and the level of interleukines IL-2 , [IL-10] considerably increases in patients with chronic inflammatory process ( abdominal tuberculoses ) . Positive_regulation IL10 TNF 21324485 2415011 EP 40 and 60 mg/kg attenuated plasma levels of and IL-6 caused by LPS , and further *increased* [IL-10] levels compared with the LPS group . Positive_regulation IL10 TNF 21344139 2399512 Prevalence analysis showed that the [IL-10] expression *followed* expression , showing a balance between them . Positive_regulation IL10 TNF 21392091 2416206 We evaluated the effect of melatonin , a versatile molecule synthesized in the pineal gland and in many organs , in heatstroke rats and showed that melatonin ( 0.2-5.0 mg/kg of body weight , i.v. , immediately after the start of heat stress ) significantly ( i ) attenuated hyperthermia , hypotension and hypothalamic ischemia and hypoxia , ( ii ) reduced plasma index of the toxic oxidizing radicals like nitric oxide metabolites and hydroxyl radicals , ( iii ) diminished plasma index of hepatic and renal dysfunction like creatinine , blood urea nitrogen , alanine aminotransferase , aspartate aminotransferase , alkaline phosphatase , and lactate dehydrogenase , ( iv ) attenuated plasma systemic inflammation response molecules like soluble intercellular and lesion molecule-1 , E-selectin , , interleukin (IL)-1ß , and IL-6 , ( v ) *promoted* plasma levels of an anti-inflammatory cytokine [IL-10] , ( vi ) reduced an index of infiltration of polymorphonuclear neutrophils in the lung like myeloperoxidase activity , and ( vii ) promoted the survival time to fourfold compared with the heatstroke alone group . Positive_regulation IL10 TNF 21411099 2438315 The angiotensin converting enzyme (ACE) inhibitors , imidaprilat and perindoprilat , enhanced the secretion of endogenous HGF , augmented the *induced* [IL-10] secretion and suppressed MCP-1 secretion from AAA tissue . Positive_regulation IL10 TNF 21745554 2471903 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL10 TNF 22103848 2514323 IL- 19 is upregulated in macrophages after infection and lessens inflammation by suppressing the production of , IL-6 and IL-12 , but not by *inducing* [IL-10] . Positive_regulation IL10 TNF 23107698 2695284 Furthermore , pre- and post treated FOs ( 0.1-100 µg/ml ) dose-dependently suppressed , IL-1ß , IL-6 and NO production , and *induced* [IL-10] production in lipopolysaccharide (LPS) stimulated RAW264.7 cells without exerting cytotoxicity . Positive_regulation IL10 TNF 23474315 2766478 In children without MN , BCG was associated with reduced response in the early sample group ( p=0.006 ) , and *increased* [IL-10] in the late sample group ( p=0.03 ) . Positive_regulation IL10 TNF 23708964 2806393 Patient whole blood cells failed to secrete IL-6 in response to IL-1ß , Pam2CSK4 , showed reduced responses to LPS and PMA/Ionomycin , and lacked [IL-10] production in *response* to . Positive_regulation IL10 TNF 2370931 138343 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL10 TNF 24165011 2879129 In this work we showed that Tat protein : i ) by its N-terminal domain induces production of both IL-10 and in a TLR4-MD2 dependent manner , ii ) interacts specifically with TLR4-MD2 and MD2 with high affinity but not with CD14 , iii ) *induces* in vivo TNF-a and [IL-10] in a TLR4 dependent manner . Positive_regulation IL10 TNF 24749687 2943429 FICZ or ITE significantly inhibited the production of IL-1ß , IL-6 , IL-23 and , but *induced* [IL-10] production by DCs derived from active BD patients and normal controls . Positive_regulation IL10 TNF 3011946 59752 Tumor necrosis interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL10 TNF 3486658 59951 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL10 TNF 3486658 60005 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL10 TNF 3486936 60094 Tumor necrosis factor ( ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL10 TNF 3500495 80703 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL10 TNF 3526909 62644 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL10 TNF 7506142 237740 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL10 TNF 7547677 327049 *Up-regulation* of monocytic [IL-10] by and cAMP elevating drugs . Positive_regulation IL10 TNF 7547677 327050 On the basis of these results , we conclude that is *involved* in the up-regulation of its antagonist [IL-10] . Positive_regulation IL10 TNF 7547677 327052 The lack of a NF-kappa B-like binding site in the human sequence suggests a NF-kappa B-independent mechanism of *induced* [IL-10] gene activation . Positive_regulation IL10 TNF 7589088 333987 Lipopolysaccharide induced [interleukin-10] in mice : *role* of endogenous . Positive_regulation IL10 TNF 7737374 305512 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL10 TNF 7964475 279563 To assess the *role* of in the induction of [IL-10] in endotoxemia , four healthy men were studied after a bolus intravenous injection of recombinant human TNF ( 50 micrograms/m2 ) . Positive_regulation IL10 TNF 7964475 279565 These results indicate that , in part , *mediates* the induction of [IL-10] in endotoxemia , resulting in an autoregulatory feedback loop . Positive_regulation IL10 TNF 8097322 217612 We demonstrate that IFN-gamma production from SCID splenocytes is stimulated by interleukin (IL) 12 , tumor necrosis factor alpha (TNF-alpha) , and IL-2 but is inhibited by [IL-10] , IL-10 , IL-12 , and are *induced* by heat killed Listeria monocytogenes ( hk-LM ) from SCID splenocytes and peritoneal macrophages . Positive_regulation IL10 TNF 8132326 251518 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL10 TNF 8258695 238783 Predominant *role* of in human monocyte [IL-10] synthesis . Positive_regulation IL10 TNF 8258695 238785 These studies concerning [IL-10] mRNA *induction* by were corroborated by studies of IL-10 protein secretion : TNF-alpha alone , but not IL-1 alpha , IL-1 beta , or IL-6 induces substantial IL-10 secretion . Positive_regulation IL10 TNF 8258695 238789 Finally , *augments* LPS induced [IL-10] secretion . Positive_regulation IL10 TNF 8548541 337100 These findings suggest that during inflammation within the brain , acute release of and IL-6 by activated microglia could *promote* subsequent release of [IL-10] , which functions to minimize the potential neurotoxic effects of proinflammatory cytokines . Positive_regulation IL10 TNF 8592105 341908 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL10 TNF 8592105 341963 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL10 TNF 8656685 364761 IL-3 , [IL-10] , IL-11 , insulin-like growth factor-I and also *stimulated* DNA synthesis in all three cell lines ; Positive_regulation IL10 TNF 8683105 370231 IL-12 and/or IL-6 can induce the expression of IL-10 by PHA stimulated T cells , whereas *induces* [IL-10] production by monocytes . Positive_regulation IL10 TNF 8910536 395205 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL10 TNF 9160997 431829 They also indicate that the *induced* [IL-10] and then down-regulates the monocytes from further TNF-alpha secretion . Positive_regulation IL10 TNF 9394829 468228 In summary , IC inhibit IL-12 secretion via *induced* [IL-10] and PG synthesis . Positive_regulation IL10 TNF 9679667 520850 Transgenic expression of cytokines in beta-cells of non-diabetes-prone mice and NOD mice has suggested pathogenic roles for IFN alpha , IFN gamma , IL-2 and [IL-10] in insulin dependent diabetes mellitus ( IDDM ) development , and protective *roles* for IL-4 , IL-6 and . Positive_regulation IL10 TNF 9927530 588644 We investigated the *role* of in the regulation of MHC class II antigens and cytokine mRNA expression of TNF , interferon-gamma (IFN) , IL-2 , IL-4 , and [IL-10] in cardiac allografts to elucidate its immunological mechanism . Positive_regulation IL10 TNFSF10 11695989 877173 These results indicate that the elevated expression of [IL-10] at the involution stage recruits lymphocytes and *induces* the expression of and DR4 . Positive_regulation IL11 ABCG2 20846001 2375395 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL11 CCL17 22057112 2540314 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL11 DAPK1 24220855 2897413 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL11 EPHB2 12609986 1085290 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL11 EPHB2 18310510 1904081 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL11 F3 7635444 317249 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL11 IL1B 12760902 1119658 [IL-11] secretion was *induced* by and transforming growth factor (TGF)-beta1 . Positive_regulation IL11 IL1B 12760902 1119672 Intestinal SEMFs secreted [IL-11] in *response* to and TGF-beta1 . Positive_regulation IL11 IL1B 14617515 1200635 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL11 IL1B 15998775 1452731 Progestin suppresses thrombin- and *induced* [interleukin-11] production in term decidual cells : implications for preterm delivery . Positive_regulation IL11 IL1B 16375968 1547124 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL11 IL1B 16616208 1582989 The expression of IL-6 and [IL-11] increased greatly in the *presence* of on day 1 and after day 14 of culture . Positive_regulation IL11 IL1B 16860880 1682243 is *induced* by [interleukin 11] during decidualization of human endometrial stromal cells , but is not released in a bioactive form . Positive_regulation IL11 IL1B 20668109 2322496 TNF and *enhanced* levels of IL11 mRNA and secreted [IL11] in cultured decidual cells . Positive_regulation IL11 IL1B 9626137 511765 Exogenous *stimulated* secretion of IL-6 and [IL-11] in a saturable , dose dependent manner . Positive_regulation IL11 IL1R2 8387521 218018 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL11 MAP2K6 19251839 2062806 inhibitors PD-98059 , U0126 , and Raf1 kinase inhibitor I , significantly *inhibited* [IL-11] production , whereas overexpression of a Raf1 dominant negative mutant inhibited its expression . Positive_regulation IL11 PGC 22117073 2535009 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL11 STAT4 7638186 317674 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL11 TLR7 12045249 950114 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL11 TLR7 18312842 1879312 Toxoplasma profilin is essential for host cell invasion and dependent *induction* of an [interleukin-12] response . Positive_regulation IL11 TLR7 20632067 2367993 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in mediated *activation* of caspase 1 and [interleukin-1ß] . Positive_regulation IL11 TLR7 22521509 2613499 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL11 TLR7 23246311 2732007 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL11 TNF 10407498 629755 IL-1 alpha and synergistically augmented TGF beta *stimulated* [IL-11] production by VSMC . Positive_regulation IL11 TNF 10407498 629758 Furthermore , IL-1 alpha , TGF beta , and *induced* [IL-11] gene expression in VSMC . Positive_regulation IL11 TNF 11254938 794199 IL-1alpha , and TGFbeta ( 0.1-10 ng/ml ) all *caused* a concentration dependent increase in [IL-11] production by both epithelial and stromal cells , but stimulated : basal values were greater for stromal than epithelial cells for all three cytokines . Positive_regulation IL11 TNF 1463043 206748 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL11 TNF 15854322 1353047 also significantly *augmented* [IL-11] production in HGFs , and synergistically stimulated HGFs to produce IL-11 when combined with IL-1alpha . Positive_regulation IL11 TNF 17854477 1795886 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving *dependent* [interleukin-12] induction . Positive_regulation IL11 TNF 20668109 2322495 and IL1B *enhanced* levels of IL11 mRNA and secreted [IL11] in cultured decidual cells . Positive_regulation IL11 TNF 2113076 135541 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL11 TNF 21593768 2454128 GW9508 further suppressed expression of [IL-11] , IL-24 , and IL-33 *induced* in HaCaT cells by and IFN-? . Positive_regulation IL11 TNF 21745554 2471905 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL11 TNF 2370931 138344 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL11 TNF 3011946 59753 interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL11 TNF 3486658 59952 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL11 TNF 3486658 60006 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL11 TNF 3486936 60095 ( cachectin ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL11 TNF 3500495 80704 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL11 TNF 3526909 62645 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL11 TNF 7506142 237741 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL11 TNF 7737374 305513 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL11 TNF 8132326 251519 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL11 TNF 8592105 341909 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL11 TNF 8592105 341964 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL11 TNF 8676079 369834 IL-1 , , PGE2 , parathyroid hormone (PTH) and 1 alpha,25-dihydroxyvitamin D3 ( 1 alpha,25 ( OH ) 2D3 ) similarly *induced* production of [IL-11] by osteoblasts , but IL-6 , IL-4 , and TGF beta did not . Positive_regulation IL11 TNF 8910536 395206 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL11 TNF 9811056 545534 The synergistic *induction* of] [IL-1alpha by and IL-11 was completely inhibited by a potent inhibitor of all isoforms of PKC , GF109203X . Positive_regulation IL12A CD14 15456540 1301188 there were also synergistic effects on inhibiting [IL-12P40] production and *inducing* and CD64 expressions by monocytes . Positive_regulation IL12A CEACAM6 25050114 2948665 and ACA *stimulated* RAW264.7 express significantly higher levels of [IL-12] while significantly higher levels of IL-10 were detected after soluble egg antigen (SEA) stimulation . Positive_regulation IL12A CST6 11238649 790904 mRNA expression and flow cytometric analysis of infected spleen cells suggested that and IFN-gamma treatment , in addition to greatly reducing parasite numbers , *resulted* in reduced levels of IL-4 but increased levels of [IL-12] and inducible NO synthase . Positive_regulation IL12A EPHB2 14556972 1153376 It seems that *roles* of and p38 MAPK for [IL-12] production are developmentally changed in murine DC . Positive_regulation IL12A EPHB2 19688743 2175827 *Activation* of p38 MAP kinase , but not or JNK , by either TCR-stimuli or [IL-12] and IL-18 is diminished in Gadd45b ( -/- ) CD8 ( + ) T cells , resulting in reduced production of IFN-gamma . Positive_regulation IL12A EPHB2 20121399 2206952 In THP-1 cells , p38 , , and JNK inhibition *increased* NF-kappaB and Sp1 binding to the [IL-12p40] promoter , while inhibiting AP-1 binding . Positive_regulation IL12A EPHB2 24434636 2922584 While p38 and JNK did not seem to play a role in the modulation properties of S1P on cytokine production , is at least partially *involved* in the S1P mediated modulation of [IL-12] and IL-27 . Positive_regulation IL12A IFI27 17702989 1788730 Thus , we hypothesized that is *involved* in elevated [IL-12] production from BWF1 BMDCs . Positive_regulation IL12A IL1B 11470775 841056 *induces* dendritic cells to produce [IL-12] . Positive_regulation IL12A IL1B 11470775 841061 Either or IFN-gamma co-induced IL-12 with CD40L but conjointly , IL-1 beta , CD40L and IFN-gamma synergized , *inducing* very high levels of [IL-12] . Positive_regulation IL12A IL1B 15730393 1377487 However , , but not IFN-gamma , *induced* [IL-12] p40 production by DCs without enhancing phenotypic maturation . Positive_regulation IL12A IL1B 16307851 1526147 PGE ( 2 ) is synergistic with and TNF-alpha in the induction of functional and phenotypic maturation of DC and *induce* [IL12] p40 production . Positive_regulation IL12A IL1B 16499573 1528908 When infected HeLa cells were co-cultured with THP-1 cells , IL-6 and IL-8 secretion was sustained , expression followed a bell shaped curve and IL-10 , [IL-12p70] and TNF-alpha synthesis was down *regulated* . Positive_regulation IL12A IL1B 17058806 1636899 alone significantly *induced* IL-12 production in DCs , whereas TNF-alpha or IFN-gamma induced modest levels of [IL-12] production . Positive_regulation IL12A IL1B 17058806 1636903 When low-dose LPS ( 1 ng/ml ) , which only slightly induced IL-12 production , was added to the culture , only an additive effect was seen on *induced* [IL-12] production . Positive_regulation IL12A IL1B 20589530 2296352 Engagement of SIGNR1 on PEMs with an anti-SIGNR1-specific rat IgM antibody , ERTR9 , *induced* production of [IL-12] and tumor necrosis factor (TNF)-alpha from PEMs , while secretion of IL-6 and was not detected with the same treatment . Positive_regulation IL12A JAG1 10861095 705280 [IL-12] is a proinflammatory cytokine secreted by dendritic cells in *response* to microbial and mitogens . Positive_regulation IL12A JAG1 16823915 1581678 also *induced* the production of [IL-12] and nitric oxide ( NO ) in the U937 human histiocyte and J774 mouse macrophage cell lines , respectively . Positive_regulation IL12A PECAM1 15114667 1241420 Activation via agonistic anti-CD38 mAb induces up-regulation of CD83 expression and IL-12 secretion , whereas disruption of interaction *inhibits* CD83 expression , [IL-12] secretion and MDDC induced allogeneic T cell proliferation . Positive_regulation IL12A PTGER2 15486065 1366918 Interestingly , the reciprocal regulation of [IL-12/IL-27] and IL-23 by ATP was mediated by 2 distinct P2 receptors and was also *induced* by prostaglandin E ( 2 ) by cyclic adenosine monophosphate ( cAMP ) -elevating receptors . Positive_regulation IL12A SPHK1 21435724 2416926 To investigate the immune modulatory *role* of as opposed to SphK2 specifically for the Th1 propagating [IL-12p70] we compared WT and SphK1 ( -/- ) splenocytes and Flt3-ligand differentiated BMCs of WT and SphK1 ( -/- ) , representing dendritic cells as major producers of IL-12p70 , incubated with LPS . Positive_regulation IL12A SPHK1 21435724 2416938 To further characterize *dependent* [IL-12p70] regulation we exogenously applied S1P , SEW2871 and the new potent S1P1 agonist CYM5442 . Positive_regulation IL12A STAT4 10820390 694508 [IL-12] *induces* sustained activation and nuclear translocation of and this regulatory process is coupled to both tyrosine and serine phosphorylation of this molecule . Positive_regulation IL12A STAT4 10820390 694519 Moreover , [IL-12] *activation* of in human peripheral blood derived T cells is not accompanied by stimulation of the Ras guanine nucleotide binding cycle or stimulation of MAPK Erk1 ,2 or initiation of the PI3K signaling pathways . Positive_regulation IL12A STAT4 11739505 886526 A mandatory *role* for in [IL-12] induction of mouse T cell CCR5 . Positive_regulation IL12A STAT4 12165484 972834 This pathway is based on a synergism of IFN-alphabeta and IL-18 , and is independent of [IL-12] signaling yet *dependent* on . Positive_regulation IL12A STAT4 15153495 1250069 In addition to [IL-12] signaling *mediated* by , STAT4 independent induction of a number of genes was observed immediately in response to Th1 induction . Positive_regulation IL12A STAT4 19710469 2133476 Although many STAT4 target genes display *dependent* [IL-12-inducible] expression , other genes displayed IL-12 induced histone modifications but lack induction , possibly due to high relative basal expression . Positive_regulation IL12A STAT4 24958858 2947368 Interrogation of mechanism showed that testosterone regulates T-helper 1 (Th1) differentiation by inhibiting IL-12 induced phosphorylation : in murine models , we determined that androgen receptor binds a conserved region within the phosphatase , Ptpn1 , and consequent up-regulation of Ptpn1 then *inhibits* [IL-12] signaling in CD4 T cells . Positive_regulation IL12A STAT4 7638186 317692 In this report we demonstrate that [IL-12] *induces* tyrosine phosphorylation of a recently identified STAT family member , , and show that STAT4 expression is regulated by T-cell activation . Positive_regulation IL12A STAT4 8700208 373000 To determine the function of and its *role* in [IL-12] signalling , we have produced mice that lack Stat4 by gene targeting . Positive_regulation IL12A STAT4 8943379 399998 *Activation* of by [IL-12] and IFN-alpha : evidence for the involvement of ligand induced tyrosine and serine phosphorylation . Positive_regulation IL12A STAT4 8943379 400005 Thus , activation was not IL-12 specific , and [IL-12] and IFN-alpha *activated* STAT4 through both tyrosine and serine phosphorylation . Positive_regulation IL12A STAT4 9574535 502530 Moreover , we showed that this increase in IFN-gamma could be explained by the dual *activation* of STAT1 and by IL-15 and [IL-12] , respectively . Positive_regulation IL12A TLR7 15153515 1250083 Although we identify TLR2 as the receptor triggering CCL2 production , parasite induced [IL-12] release did not *involve* this . Positive_regulation IL12A TLR7 15851485 1399476 Dendritic cells ( DC ) produce [interleukin-12 (IL-12)] in *response* to activation . Positive_regulation IL12A TLR7 15851485 1399516 Moreover , analysis of interferon regulatory factors (IRF) regulation in moDC suggests a role for IRF7/8 in mediating IRF3 independent type I IFN and possibly [IL-12p35] synthesis in *response* to . Positive_regulation IL12A TLR7 15860593 1418971 Moreover , is *required* in vivo for parasite induced [IL-12] production and optimal resistance to infection , thereby establishing a role for the receptor in host recognition of protozoan pathogens . Positive_regulation IL12A TLR7 16009271 1431441 However , [IL-12p70] production in *response* to stimulating agents plus IFN-gamma was consistently lower in AIMV medium although also under serumfree culture conditions , nanogram quantities of IL-12 were produced . Positive_regulation IL12A TLR7 16239426 1518088 Of interest , DCAL-2 ligation had the opposite effects on TLR versus CD40L signaling : anti-DCAL-2 suppressed *induced* [IL-12] expression , but significantly enhanced CD40L induced IL-12 production . Positive_regulation IL12A TLR7 16413922 1514408 IkappaBNS-deficient macrophages and dendritic cells show increased *mediated* expression of genes such as IL-6 and [IL-12p40] , which are induced late after TLR stimulation . Positive_regulation IL12A TLR7 16461743 1540905 Moreover , they lack MDP induced enhancement of *mediated* tumor necrosis factor alpha , [interleukin (IL)-12] , and IL-10 production , which is observed in control DC with intact NOD2 . Positive_regulation IL12A TLR7 16751389 1571005 T cell independent , *induced* [IL-12p70] production in primary human monocytes . Positive_regulation IL12A TLR7 16751389 1571030 [IL-12p70] production in peripheral blood myeloid dendritic cells *required* combined stimulation of ligands together with TLR4 or with TLR3 ligands . Positive_regulation IL12A TLR7 16751389 1571034 In the presence of T cell derived IL-4 , but not IFN-gamma , stimulation with ligands was *sufficient* to stimulate [IL-12p70] production . Positive_regulation IL12A TLR7 17579043 1763734 Role of phosphatidylinositol-3 kinase in transcriptional regulation of *induced* [IL-12] and IL-10 by Fc gamma receptor ligation in murine macrophages . Positive_regulation IL12A TLR7 17579043 1763764 Because PI3K deficiency has been associated with increased IL-12 , we hypothesized that PI3K was central to the anti-inflammatory effect of FcgammaR ligation on *induced* [IL-12] . Positive_regulation IL12A TLR7 17579043 1763794 This increase was blocked by PI3K inhibitors , wortmannin or LY294002 , as was the effect of FcgammaR ligation on *induced* [IL-12] and IL-10 . Positive_regulation IL12A TLR7 17785797 1790708 In primary macrophages from mice with a targeted deletion of the atf3 gene ( ATF3-knockout ( KO ) ) , *stimulated* levels of [IL-12] and IL-6 were elevated relative to responses in wild-type macrophages . Positive_regulation IL12A TLR7 17881511 1823698 Herein , ligation of gC1qR on human monocyte derived DCs ( MDDCs ) with HCV core or anti-gC1qR agonist antibody was shown to inhibit *induced* [IL-12] production but not the production of other TLR stimulated cytokines . Positive_regulation IL12A TLR7 17918201 1819380 In this study , we investigated which mouse B cell subsets are the most potent cytokine producers , and examined the *role* of in the control of secretion of IL-6 , IL-10 , [IL-12] and IFN-gamma by B cells . Positive_regulation IL12A TLR7 18209037 1857697 Exposure of bone marrow derived dendritic cells to E2 also enhanced production of [IL-12] in *response* to the ligands , CpG and LPS . Positive_regulation IL12A TLR7 18271077 1865818 Stimulation with TLR2 , TLR4 and ligands , as well as TLR3 ligand , *resulted* in significantly lower production of TNF-alpha , but neither IL-6 nor [IL-12p70] , by DCs from XLA patients in comparison to normal controls . Positive_regulation IL12A TLR7 18461564 1916431 However , there was little induction of [IL-12] by either subset in *response* to ligation . Positive_regulation IL12A TLR7 18713972 1950772 A number of recent studies show that activation of CR3 on dendritic cells (DCs) suppresses *induced* TNF-alpha and [IL-12] production and inhibits effective Ag presentation . Positive_regulation IL12A TLR7 18713972 1950802 *induced* TNF-alpha and [IL-12] production by bone marrow derived DCs occurs heterogeneously , with apoptotic cells inhibiting only certain populations depending on the TLR agonist . Positive_regulation IL12A TLR7 19201871 2033869 Kinetic of RelA activation controls magnitude of mediated [IL-12p40] *induction* . Positive_regulation IL12A TLR7 19322177 2064466 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and [IL-12p40] ( also known as IL12b ) , but not TNF , in *response* to ligands . Positive_regulation IL12A TLR7 19430534 2077868 Moreover , *dependent* IL6 and [IL12P40] production induced by lipopolysaccharide (LPS) , R837 or CpG ODN 1826 was reduced in IRF-5 ( P68 ) expressing cells as compared to the control cells . Positive_regulation IL12A TLR7 19637227 2143068 Neonatal myeloid DC were shown to be deficient in IFN-beta and [IL-12] synthesis in *response* to triggering . Positive_regulation IL12A TLR7 19917677 2166670 In *response* to most ligands , neonatal innate immune cells , including monocytes and conventional and plasmacytoid dendritic cells produced less [IL-12p70] and IFN-alpha ( and consequently induced less IFN-gamma ) , moderately less TNF-alpha , but as much or even more IL-1beta , IL-6 , IL-23 , and IL-10 than adult cells . Positive_regulation IL12A TLR7 19933865 2172055 Tpl2 ( -/- ) macrophages have abrogated TNF production but overproduce [IL-12] in *response* to ligands . Positive_regulation IL12A TLR7 20112371 2219498 Sigirr-deficient dendritic cells expressed higher TLR7 mRNA levels and activation *resulted* in increased [IL-12] production in vitro . Positive_regulation IL12A TLR7 20408896 2300616 In the present study , we examined the effect of prostaglandin E ( 2 ) ( PGE ( 2 ) ) treatment of DCs during differentiation on [IL-12] and IL-23 production in *response* to stimulation . Positive_regulation IL12A TLR7 20822377 2375332 Furthermore , the MDSC inhibited *induced* [IL-12] production of DC by IL-10 production and suppressed T cell stimulatory activity of DC . Positive_regulation IL12A TLR7 20840632 2363797 ligation by small chemical molecules will still *induce* interleukin-6 (IL-6) and tumour necrosis factor-a secretion , but not interferon-a or [IL-12] . Positive_regulation IL12A TLR7 20851125 2331461 Substitution of the acidic loop in TgPRF with the homologous loop from the apicomplexan parasite Cryptosporidium parvum does not affect *dependent* [IL-12] secretion , while substitution with the acidic loop from Plasmodium falciparum results in reduced but significant IL-12 secretion . Positive_regulation IL12A TLR7 21097503 2383190 A deficiency in functional UNC93B1 protein abolished *dependent* [IL-12] secretion by dendritic cells , attenuated Th1 responses against T. gondii , and dramatically enhanced susceptibility to the parasite . Positive_regulation IL12A TLR7 21106540 2389831 Mouse macrophages produce [IL-12] and IL-10 in *response* to ligands such as LPS , CpG , Poly I:C and Malp2 . Positive_regulation IL12A TLR7 21106540 2389881 The *induced* [IL-12] production was decreased , while that of IL-10 was increased by concurrent stimulation with a complement fragment C5a . Positive_regulation IL12A TLR7 21190998 2391266 In the present study , we show for the first time that IL-29 can increase *induced* [IL-12p40] production by human monocyte derived macrophages . Positive_regulation IL12A TLR7 21263070 2392651 PD-1 and SOCS-1 were found to associate by coimmunoprecipitation studies , and blocking PD-1 or silencing SOCS-1 in M/M ( F ) led to activation of STAT-1 during *stimulated* [IL-12] production . Positive_regulation IL12A TLR7 21741305 2490032 ligands of Lactobacillus sakei LK-117 isolated from seed mash for brewing sake are potent *inducers* of [IL-12] . Positive_regulation IL12A TLR7 22345668 2572028 Knockdown of hnRNP U expression greatly attenuated *induced* expression of TNF-a , IL-6 , and IL-1ß , but not [IL-12] , whereas hnRNP U overexpression greatly increased TLR induced expression of TNF-a , IL-6 , and IL-1ß . Positive_regulation IL12A TLR7 22440523 2600821 The expression of *induced* production of TNF-a , IFN-a , IL-6 , and [IL-12] were measured by multicolor flow cytometry . Positive_regulation IL12A TLR7 22536449 2590107 Here , we examine the *role* of and reactive oxygen species ( ROS ) in [IL-12] production by LAB stimulated peritoneal macrophages . Positive_regulation IL12A TLR7 22536449 2590147 Our results indicate that a is not *necessary* for [IL-12] induction by LAB , whilst the universal adaptor protein , MyD88 , is essential . Positive_regulation IL12A TLR7 22685028 2659127 Type I and III interferons enhance IL-10R expression on human monocytes and macrophages , resulting in IL-10 mediated suppression of *induced* [IL-12] . Positive_regulation IL12A TLR7 22685028 2659159 This indicates that IFN-a increased the sensitivity of monocytes to IL-10 , and as a result , *induced* [IL-12p70] by IFN pretreated cells was suppressed . Positive_regulation IL12A TLR7 22685028 2659189 In summary , we demonstrate that one of the consequences of priming human APCs with IFN is to promote the cells ' sensitivity to IL-10 , which leads to the inhibition of *induced* [IL-12p70] production . Positive_regulation IL12A TLR7 22685319 2676008 Interestingly , despite expression of TLR mRNA on Kupffer cells , ligation of TLR4 , , and TLR9 *resulted* in a weak induction of IL-10 , low or undetectable levels of [IL-12p40] and TNF , and up-regulation of CD40 on the surface . Positive_regulation IL12A TLR7 22777843 2682022 We found here that was partially *required* for the induction of [IL-12] ( IL-12p70 ) by Candida albicans or Saccharomyces cerevisiae . Positive_regulation IL12A TLR7 22896020 2677822 The combination of ligands for and TLR3 *led* to synergistic secretion of both IL-23 and [IL-12p70] from all subjects ; Positive_regulation IL12A TLR7 22896633 2666483 p38 MAPK activation and IL-12p70 production was more robust from TFF2 ( -/- ) CD8+ DC compared with WT CD8+ DC and treatment of WT DC with rTFF2 suppressed *induced* [IL-12/23p40] production . Positive_regulation IL12A TLR7 23074227 2706653 Notably , the phosphoinositide 3-kinase (PI3K) pathway suppresses *induced* [IL-12] production as an auto-inhibitory regulator in dendritic cells . Positive_regulation IL12A TLR7 23074227 2706683 However , Okazaki et al. ( C5a controls *induced* IL-10 and [IL-12] production independent of phosphoinositide 3-kinase . Positive_regulation IL12A TLR7 23074227 2706703 2011 ; 149 : 265-274 ) recently indicated that PI3K activated downstream of C5a anaphylatoxin does not affect the *induction* of [IL-12] by , although C5a efficiently inhibits the induction , in macrophages . Positive_regulation IL12A TLR7 23246311 2732231 dependent *induction* of [IL-12] and IFN-a in pDCs led to production of IFN-? by NK cells . Positive_regulation IL12A TLR7 23504259 2809787 Adenosine signaling suppresses the *dependent* expression of TNF-a , [IL-12] , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Positive_regulation IL12A TLR7 23750720 2834114 In contrast to humans , pDC in rhesus macaques expressed the [interleukin (IL)-12p40] subunit in *response* to as well as TLR-9 stimulation . Positive_regulation IL12A TLR7 23755218 2797767 The aim of our study was to define the relative contribution of age and clinical status on *induced* [interleukin (IL)-12p70] and IL-23 production as these cytokines play an important role in the protection against intracellular and extracellular pathogens , respectively . Positive_regulation IL12A TLR7 23966630 2836163 Whereas TLR9 induced TNF-a secretion of bone marrow derived macrophages and conventional dendritic cells was equally inhibited by INH-ODN 2088 and G-modified INH-ODNs such as INH-ODN 24888 , *induced* TNF-a release and TLR7- and TLR9 induced [IL-12p40] release were significantly more impaired by G-modified INH-ODNs . Positive_regulation IL12A TLR7 24078692 2857902 In this study , we establish that , in addition to TLR11 , recognizes the profilin protein of the protozoan parasite Toxoplasma gondii and *regulates* [IL-12] production by DCs in response to the parasite . Positive_regulation IL12A TLR7 24078692 2857942 We also establish that the transcription factor IFN regulatory factor 8 , not NF-?B , plays a central role in the regulation of the TLR11- and *dependent* [IL-12] response of DCs . Positive_regulation IL12A TNF 10513808 651493 *restored* LPS stimulated [IL-12] production that had been inhibited by rolipram . Positive_regulation IL12A TNF 11013010 736265 In vitro [IL-12] production by Th1 type granuloma macrophages was *enhanced* by and IFNgamma , whereas lymphocyte IL-12 responsiveness was boosted only by TNF-alpha . Positive_regulation IL12A TNF 11157054 780716 Initial comparisons indicated that alpha induction of epithelial intercellular adhesion molecule 1 *required* sequential induction of [interleukin (IL)-12] ( p70 ) and interferon gamma , and unexpectedly localized IL-12 production to airway epithelial cells . Positive_regulation IL12A TNF 12010985 941366 These findings demonstrate that afferent-phase production is *essential* for the induction of [IL-12] and IFN-gamma and neutralization of early TNF-alpha results in a T2 shift of the T1/T2 balance of antifungal immunity . Positive_regulation IL12A TNF 12115630 964242 Colonic expression of IFN-gamma and was elevated ( 200- and 150-fold , respectively ) and IFN-gamma and [IL-12] secretion from lymph node cells was *increased* 5,000- and 8-fold , respectively , compared to GpG-ODN treated controls . Positive_regulation IL12A TNF 12207325 983554 We observed that ATPgammaS potentiated the [IL-12p40] release *induced* by , but also by lipopolysaccharides (LPS) and soluble CD40 ligand ( sCD40L ) . Positive_regulation IL12A TNF 12574344 1057856 TNF-alpha and RANKL cooperated with CD40L via differing mechanisms , i.e. , *enhanced* [IL-12] production , whereas RANKL enhanced survival of CD40L stimulated DCs . Positive_regulation IL12A TNF 1373169 183256 Thus , [IL-12] can directly influence NK cell activities in purified CD56+ cells , and endogenously produced is *involved* in mediating the effects of both IL-12 and IL-7 . Positive_regulation IL12A TNF 14670333 1188955 In an attempt to determine the *role* of IFN-gamma and in [IL-12] induced immunity , IFN-gamma and TNFR-p55 knockout mice were immunized with rSm14/IL-12 and no protection was achieved . Positive_regulation IL12A TNF 15683451 1370615 Polyriboinosinic polyribocytidylic acid ( Poly I:C ) + *induced* significant [IL-12] p70 secretion , which was increased after addition of a decoy IL-10 receptor . Positive_regulation IL12A TNF 16279537 1480577 In culture medium with ripe DC the levels of such cytokines as IL-1b , IL-6 , [IL-12] , IFN-gamma , significantly *increased* and the production of IL-4 decreased . Positive_regulation IL12A TNF 16307851 1526146 PGE ( 2 ) is synergistic with IL-1beta and in the induction of functional and phenotypic maturation of DC and *induce* [IL12] p40 production . Positive_regulation IL12A TNF 16522779 1531513 Interestingly , we found that when weakly IL-12- and TNF-alpha inducing LAB and strong IL-12- and TNF-alpha inducing LAB were mixed , the weakly IL-12- and TNF-alpha inducing LAB efficiently inhibited otherwise strong [IL-12-] and TNF-alpha inducing LAB , yet when weakly IL-12- and TNF-alpha inducing LAB were mixed with G- bacteria , they synergistically *induced* IL-12 and . Positive_regulation IL12A TNF 17058806 1636897 IL-1beta alone significantly induced IL-12 production in DCs , whereas or IFN-gamma *induced* modest levels of [IL-12] production . Positive_regulation IL12A TNF 17058806 1636907 These findings suggest that the p38 MAPK pathway is essential for the synergistic [IL-12] production *induced* by or IFN-gamma in combination with low-dose LPS in DC . Positive_regulation IL12A TNF 17854477 1795902 These data indicate that CpG-ODN protects animals against lethal C. albicans challenge via a pathway that involves the *dependent* induction of [IL-12] . Positive_regulation IL12A TNF 18760623 1975405 *stimulated* secretion of [IL-12p40] was significantly increased by 30 min ; Positive_regulation IL12A TNF 19273561 2063314 YGPs stimulated secretion of the proinflammatory cytokine in wild-type murine bone marrow derived myeloid dendritic cells ( BMDCs ) but did not *stimulate* [interleukin-12p70 (IL-12p70)] production . Positive_regulation IL12A TNF 19607809 2123911 Both OA-NO ( 2 ) and LNO ( 2 ) prevented *stimulated* release of the cytokines , IL-6 , IL-8 , [IL-12/p40] , IFNgamma , MCP-1 , and IP-10 , and inhibited NF-kappaB activation . Positive_regulation IL12A TNF 19702865 2247682 rhamnosus *induced* higher levels of TNF-alpha , IL-6 and [IL-12] but inhibited IL-10 production , whereas its mucous variant induced low or no and IL-6 . Positive_regulation IL12A TNF 20822815 2346069 On day 12 , induction in monocyte derived macrophages and [IL-12] p40 *induction* in BAL macrophages infected with R. equi was significantly higher in foals treated with PPVO than in controls . Positive_regulation IL12A TNF 8097322 217613 We demonstrate that IFN-gamma production from SCID splenocytes is stimulated by [interleukin (IL) 12] , tumor necrosis factor alpha (TNF-alpha) , and IL-2 but is inhibited by IL-10 , IL-10 , IL-12 , and are *induced* by heat killed Listeria monocytogenes ( hk-LM ) from SCID splenocytes and peritoneal macrophages . Positive_regulation IL12A TNF 8683105 370235 [IL-12] and/or IL-6 can *induce* the expression of IL-10 by PHA stimulated T cells , whereas induces IL-10 production by monocytes . Positive_regulation IL12A TNF 8876217 390348 Interferon gamma , IL-10 , and could be *induced* throughout the treatment period by [IL-12] , indicating that repeated injections of IL-12 do not induce a state of tachyphylaxis . Positive_regulation IL12A TNF 8977306 403215 Furthermore , [IL-12] up-regulated TNF receptors on gammadelta T cells in vitro : binding to its receptor *induced* CD25 expression on the gammadelta T cells in an autocrine or paracrine fashion , or perhaps both . Positive_regulation IL12A TNF 9038291 415445 The production of IFN-gamma is *induced* by [IL-12] with as a costimulator and inhibited by IL-10 . Positive_regulation IL12A TNF 9573060 501924 The number of bacteria in the macrophages infected with 103- and HK decreased progressively , whereas the 103+ numbers remained constant over 48 h . Interleukin 1beta (IL-1beta) , IL-6 , IL-10 , [IL-12] p40 , and mRNA *induction* peaked at 4 h and returned to baseline between 12 and 48 h postinfection . Positive_regulation IL12A TNF 9647251 514990 The expression of both [IL-12] protein and mRNAs for the p35 and p40 IL-12 subunits was strongly induced in all donors by the Th2-like cytokines IL-4 and granulocyte-macrophage CSF and was also moderately *induced* by and IL-1alpha . Positive_regulation IL12A TNF 9806041 544745 protein expression occurred earlier than IL-12 p40 protein but was not *required* for [IL-12] induction . Positive_regulation IL12A TNF 9848688 554041 Whether these lipid A-common Re595 LPS preparations differed in activities , we investigated their effects on nitric oxide ( NO ) , , IL-6 , and [IL-12] *induction* from murine macrophage cell line RAW 264.7 . Positive_regulation IL12A TNF 9916686 587477 Based on previous work that suggests that the production of [IL-12] by activated human central nervous system derived microglia is *regulated* by autocrine , we wanted to determine whether inhibition of TNF could induce a reduction of Th1 responses by its impact on systemic APCs . Positive_regulation IL12A TNFSF10 11774735 890601 Consisting with this finding , [IL-12] and NKT cell specific ligand , alpha-Galactosylceramide ( alpha-GalCer ) , *induced* TRAIL mediated cytotoxcity and anti-tumor effect , and which was mediated by expressed on IFN-gamma activated NK cells . Positive_regulation IL12A TP63 16249388 1518250 Hydrogen peroxide inhibits [IL-12] *induction* in macrophages by inhibiting c-rel translocation to the nucleus through activation of calmodulin protein . Positive_regulation IL12B ANGPT1 24404127 2900498 While TNF enhanced expression of a common restricted set of genes involved in angiogenesis and inflammation in GM-CSF , IFN-? and IL-10 -differentiated macrophages , expression of multiple chemokines and cytokines , including CXCL3 , CXCL5 , CXCL8 , IL6 , and [IL12B] was further augmented in the *presence* of and Ang-2 , via Tie2 activation of JAK/STAT signaling . Positive_regulation IL12B CD14 15456540 1301190 there were also synergistic effects on inhibiting [IL-12P40] production and *inducing* and CD64 expressions by monocytes . Positive_regulation IL12B CD14 15516327 1328551 LPS induced increase of [IL-23] and IL-12 subunits expression was *dependent* , while CD14 was not involved in SAC induced p19 transcription . Positive_regulation IL12B CEACAM6 25050114 2948666 and ACA *stimulated* RAW264.7 express significantly higher levels of [IL-12] while significantly higher levels of IL-10 were detected after soluble egg antigen (SEA) stimulation . Positive_regulation IL12B CST6 11238649 790914 mRNA expression and flow cytometric analysis of infected spleen cells suggested that and IFN-gamma treatment , in addition to greatly reducing parasite numbers , *resulted* in reduced levels of IL-4 but increased levels of [IL-12] and inducible NO synthase . Positive_regulation IL12B EPHB2 14556972 1153390 It seems that *roles* of and p38 MAPK for [IL-12] production are developmentally changed in murine DC . Positive_regulation IL12B EPHB2 19688743 2175828 *Activation* of p38 MAP kinase , but not or JNK , by either TCR-stimuli or [IL-12] and IL-18 is diminished in Gadd45b ( -/- ) CD8 ( + ) T cells , resulting in reduced production of IFN-gamma . Positive_regulation IL12B EPHB2 20121399 2206954 In THP-1 cells , p38 , , and JNK inhibition *increased* NF-kappaB and Sp1 binding to the [IL-12p40] promoter , while inhibiting AP-1 binding . Positive_regulation IL12B EPHB2 24434636 2922585 While p38 and JNK did not seem to play a role in the modulation properties of S1P on cytokine production , is at least partially *involved* in the S1P mediated modulation of [IL-12] and IL-27 . Positive_regulation IL12B IFI27 17702989 1788736 Thus , we hypothesized that is *involved* in elevated [IL-12] production from BWF1 BMDCs . Positive_regulation IL12B IL1B 11470775 841057 *induces* dendritic cells to produce [IL-12] . Positive_regulation IL12B IL1B 11470775 841063 Either or IFN-gamma co-induced IL-12 with CD40L but conjointly , IL-1 beta , CD40L and IFN-gamma synergized , *inducing* very high levels of [IL-12] . Positive_regulation IL12B IL1B 15730393 1377489 However , , but not IFN-gamma , *induced* [IL-12] p40 production by DCs without enhancing phenotypic maturation . Positive_regulation IL12B IL1B 16307851 1526149 PGE ( 2 ) is synergistic with and TNF-alpha in the induction of functional and phenotypic maturation of DC and *induce* [IL12] p40 production . Positive_regulation IL12B IL1B 16499573 1528909 When infected HeLa cells were co-cultured with THP-1 cells , IL-6 and IL-8 secretion was sustained , expression followed a bell shaped curve and IL-10 , [IL-12p70] and TNF-alpha synthesis was down *regulated* . Positive_regulation IL12B IL1B 16622035 1551581 further *increased* the production of [IL-23] , which induced IL-17 production and OX40 expression in splenic CD4 ( + ) T cells of IL-1Ra ( -/- ) mice . Positive_regulation IL12B IL1B 17058806 1636902 alone significantly *induced* IL-12 production in DCs , whereas TNF-alpha or IFN-gamma induced modest levels of [IL-12] production . Positive_regulation IL12B IL1B 17058806 1636904 When low-dose LPS ( 1 ng/ml ) , which only slightly induced IL-12 production , was added to the culture , only an additive effect was seen on *induced* [IL-12] production . Positive_regulation IL12B IL1B 18390747 1893327 IL-17A , IL-17F , and [IL-23] could *induce* the release of chemokines GRO-alpha/CXCL1 , IL-8/CXCL8 , and MIP-1beta/CCL4 from eosinophils , while IL-17F and IL-23 could also increase the production of proinflammatory cytokines and IL-6 . Positive_regulation IL12B IL1B 18802048 1964477 Moreover , alone *triggered* [IL-23] secretion and the IL-1R antagonist inhibited this response in PBMC and purified monocytes . Positive_regulation IL12B IL1B 20589530 2296354 Engagement of SIGNR1 on PEMs with an anti-SIGNR1-specific rat IgM antibody , ERTR9 , *induced* production of [IL-12] and tumor necrosis factor (TNF)-alpha from PEMs , while secretion of IL-6 and was not detected with the same treatment . Positive_regulation IL12B JAG1 10861095 705281 [IL-12] is a proinflammatory cytokine secreted by dendritic cells in *response* to microbial and mitogens . Positive_regulation IL12B JAG1 16823915 1581679 also *induced* the production of [IL-12] and nitric oxide ( NO ) in the U937 human histiocyte and J774 mouse macrophage cell lines , respectively . Positive_regulation IL12B PECAM1 15114667 1241422 Activation via agonistic anti-CD38 mAb induces up-regulation of CD83 expression and IL-12 secretion , whereas disruption of interaction *inhibits* CD83 expression , [IL-12] secretion and MDDC induced allogeneic T cell proliferation . Positive_regulation IL12B PTGER2 15486065 1366920 Interestingly , the reciprocal regulation of [IL-12/IL-27] and IL-23 by ATP was mediated by 2 distinct P2 receptors and was also *induced* by prostaglandin E ( 2 ) by cyclic adenosine monophosphate ( cAMP ) -elevating receptors . Positive_regulation IL12B SPHK1 21435724 2416927 To investigate the immune modulatory *role* of as opposed to SphK2 specifically for the Th1 propagating [IL-12p70] we compared WT and SphK1 ( -/- ) splenocytes and Flt3-ligand differentiated BMCs of WT and SphK1 ( -/- ) , representing dendritic cells as major producers of IL-12p70 , incubated with LPS . Positive_regulation IL12B SPHK1 21435724 2416939 To further characterize *dependent* [IL-12p70] regulation we exogenously applied S1P , SEW2871 and the new potent S1P1 agonist CYM5442 . Positive_regulation IL12B STAT4 10820390 694509 [IL-12] *induces* sustained activation and nuclear translocation of and this regulatory process is coupled to both tyrosine and serine phosphorylation of this molecule . Positive_regulation IL12B STAT4 10820390 694520 Moreover , [IL-12] *activation* of in human peripheral blood derived T cells is not accompanied by stimulation of the Ras guanine nucleotide binding cycle or stimulation of MAPK Erk1 ,2 or initiation of the PI3K signaling pathways . Positive_regulation IL12B STAT4 11739505 886527 A mandatory *role* for in [IL-12] induction of mouse T cell CCR5 . Positive_regulation IL12B STAT4 12165484 972835 This pathway is based on a synergism of IFN-alphabeta and IL-18 , and is independent of [IL-12] signaling yet *dependent* on . Positive_regulation IL12B STAT4 15153495 1250070 In addition to [IL-12] signaling *mediated* by , STAT4 independent induction of a number of genes was observed immediately in response to Th1 induction . Positive_regulation IL12B STAT4 19710469 2133477 Although many STAT4 target genes display *dependent* [IL-12-inducible] expression , other genes displayed IL-12 induced histone modifications but lack induction , possibly due to high relative basal expression . Positive_regulation IL12B STAT4 24958858 2947369 Interrogation of mechanism showed that testosterone regulates T-helper 1 (Th1) differentiation by inhibiting IL-12 induced phosphorylation : in murine models , we determined that androgen receptor binds a conserved region within the phosphatase , Ptpn1 , and consequent up-regulation of Ptpn1 then *inhibits* [IL-12] signaling in CD4 T cells . Positive_regulation IL12B STAT4 7638186 317693 In this report we demonstrate that [IL-12] *induces* tyrosine phosphorylation of a recently identified STAT family member , , and show that STAT4 expression is regulated by T-cell activation . Positive_regulation IL12B STAT4 8700208 373001 To determine the function of and its *role* in [IL-12] signalling , we have produced mice that lack Stat4 by gene targeting . Positive_regulation IL12B STAT4 8943379 399999 *Activation* of by [IL-12] and IFN-alpha : evidence for the involvement of ligand induced tyrosine and serine phosphorylation . Positive_regulation IL12B STAT4 8943379 400006 Thus , activation was not IL-12 specific , and [IL-12] and IFN-alpha *activated* STAT4 through both tyrosine and serine phosphorylation . Positive_regulation IL12B STAT4 9574535 502532 Moreover , we showed that this increase in IFN-gamma could be explained by the dual *activation* of STAT1 and by IL-15 and [IL-12] , respectively . Positive_regulation IL12B TLR7 15153515 1250093 Although we identify TLR2 as the receptor triggering CCL2 production , parasite induced [IL-12] release did not *involve* this . Positive_regulation IL12B TLR7 15851485 1399486 Dendritic cells ( DC ) produce [interleukin-12 (IL-12)] in *response* to activation . Positive_regulation IL12B TLR7 15851485 1399518 Moreover , analysis of interferon regulatory factors (IRF) regulation in moDC suggests a role for IRF7/8 in mediating IRF3 independent type I IFN and possibly [IL-12p35] synthesis in *response* to . Positive_regulation IL12B TLR7 15860593 1418981 Moreover , is *required* in vivo for parasite induced [IL-12] production and optimal resistance to infection , thereby establishing a role for the receptor in host recognition of protozoan pathogens . Positive_regulation IL12B TLR7 16009271 1431451 However , [IL-12p70] production in *response* to stimulating agents plus IFN-gamma was consistently lower in AIMV medium although also under serumfree culture conditions , nanogram quantities of IL-12 were produced . Positive_regulation IL12B TLR7 16239426 1518100 Of interest , DCAL-2 ligation had the opposite effects on TLR versus CD40L signaling : anti-DCAL-2 suppressed *induced* [IL-12] expression , but significantly enhanced CD40L induced IL-12 production . Positive_regulation IL12B TLR7 16413922 1514418 IkappaBNS-deficient macrophages and dendritic cells show increased *mediated* expression of genes such as IL-6 and [IL-12p40] , which are induced late after TLR stimulation . Positive_regulation IL12B TLR7 16461743 1540915 Moreover , they lack MDP induced enhancement of *mediated* tumor necrosis factor alpha , [interleukin (IL)-12] , and IL-10 production , which is observed in control DC with intact NOD2 . Positive_regulation IL12B TLR7 16751389 1571015 T cell independent , *induced* [IL-12p70] production in primary human monocytes . Positive_regulation IL12B TLR7 16751389 1571031 [IL-12p70] production in peripheral blood myeloid dendritic cells *required* combined stimulation of ligands together with TLR4 or with TLR3 ligands . Positive_regulation IL12B TLR7 16751389 1571036 In the presence of T cell derived IL-4 , but not IFN-gamma , stimulation with ligands was *sufficient* to stimulate [IL-12p70] production . Positive_regulation IL12B TLR7 17475882 1738486 MyD88-/- mice were used to assess E. faecalis/E. coli induced *dependent* signaling and [IL-23] gene expression . Positive_regulation IL12B TLR7 17579043 1763746 Role of phosphatidylinositol-3 kinase in transcriptional regulation of *induced* [IL-12] and IL-10 by Fc gamma receptor ligation in murine macrophages . Positive_regulation IL12B TLR7 17579043 1763774 Because PI3K deficiency has been associated with increased IL-12 , we hypothesized that PI3K was central to the anti-inflammatory effect of FcgammaR ligation on *induced* [IL-12] . Positive_regulation IL12B TLR7 17579043 1763804 This increase was blocked by PI3K inhibitors , wortmannin or LY294002 , as was the effect of FcgammaR ligation on *induced* [IL-12] and IL-10 . Positive_regulation IL12B TLR7 17785797 1790718 In primary macrophages from mice with a targeted deletion of the atf3 gene ( ATF3-knockout ( KO ) ) , *stimulated* levels of [IL-12] and IL-6 were elevated relative to responses in wild-type macrophages . Positive_regulation IL12B TLR7 17881511 1823708 Herein , ligation of gC1qR on human monocyte derived DCs ( MDDCs ) with HCV core or anti-gC1qR agonist antibody was shown to inhibit *induced* [IL-12] production but not the production of other TLR stimulated cytokines . Positive_regulation IL12B TLR7 17897860 1811291 TLR3 and are *involved* in expression of [IL-23] subunits while TLR3 but not TLR7 is involved in expression of IFN-beta by Theiler 's virus infected RAW264.7 cells . Positive_regulation IL12B TLR7 17918201 1819390 In this study , we investigated which mouse B cell subsets are the most potent cytokine producers , and examined the *role* of in the control of secretion of IL-6 , IL-10 , [IL-12] and IFN-gamma by B cells . Positive_regulation IL12B TLR7 17919942 1819506 MDP enhanced obligate bacterial agonist *induction* of [IL-23] and IL-1 , which promoted IL-17 expression in T cells . Positive_regulation IL12B TLR7 18209037 1857707 Exposure of bone marrow derived dendritic cells to E2 also enhanced production of [IL-12] in *response* to the ligands , CpG and LPS . Positive_regulation IL12B TLR7 18271077 1865820 Stimulation with TLR2 , TLR4 and ligands , as well as TLR3 ligand , *resulted* in significantly lower production of TNF-alpha , but neither IL-6 nor [IL-12p70] , by DCs from XLA patients in comparison to normal controls . Positive_regulation IL12B TLR7 18276743 2010198 *dependent* induction of p19 , p40 and bioactive [IL23] was determined in RA synovial fibroblasts ( RASF ) , monocytes and monocyte derived dendritic cells ( MDDCs ) by real-time PCR and reverse transcriptase ( RT ) -PCR , Western blot and functional assays . Positive_regulation IL12B TLR7 18461564 1916441 However , there was little induction of [IL-12] by either subset in *response* to ligation . Positive_regulation IL12B TLR7 18713972 1950782 A number of recent studies show that activation of CR3 on dendritic cells (DCs) suppresses *induced* TNF-alpha and [IL-12] production and inhibits effective Ag presentation . Positive_regulation IL12B TLR7 18713972 1950812 *induced* TNF-alpha and [IL-12] production by bone marrow derived DCs occurs heterogeneously , with apoptotic cells inhibiting only certain populations depending on the TLR agonist . Positive_regulation IL12B TLR7 18802116 1964980 Notably , [IL-23] production in *response* to single ligands was inhibited by IL-4 . Positive_regulation IL12B TLR7 19201871 2033879 Kinetic of RelA activation controls magnitude of mediated [IL-12p40] *induction* . Positive_regulation IL12B TLR7 19322177 2064476 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and [IL-12p40] ( also known as IL12b ) , but not TNF , in *response* to ligands . Positive_regulation IL12B TLR7 19430534 2077878 Moreover , *dependent* IL6 and [IL12P40] production induced by lipopolysaccharide (LPS) , R837 or CpG ODN 1826 was reduced in IRF-5 ( P68 ) expressing cells as compared to the control cells . Positive_regulation IL12B TLR7 19637227 2143078 Neonatal myeloid DC were shown to be deficient in IFN-beta and [IL-12] synthesis in *response* to triggering . Positive_regulation IL12B TLR7 19917677 2166680 In *response* to most ligands , neonatal innate immune cells , including monocytes and conventional and plasmacytoid dendritic cells produced less [IL-12p70] and IFN-alpha ( and consequently induced less IFN-gamma ) , moderately less TNF-alpha , but as much or even more IL-1beta , IL-6 , IL-23 , and IL-10 than adult cells . Positive_regulation IL12B TLR7 19933865 2172065 Tpl2 ( -/- ) macrophages have abrogated TNF production but overproduce [IL-12] in *response* to ligands . Positive_regulation IL12B TLR7 20112371 2219499 Sigirr-deficient dendritic cells expressed higher TLR7 mRNA levels and activation *resulted* in increased [IL-12] production in vitro . Positive_regulation IL12B TLR7 20408896 2300626 In the present study , we examined the effect of prostaglandin E ( 2 ) ( PGE ( 2 ) ) treatment of DCs during differentiation on [IL-12] and IL-23 production in *response* to stimulation . Positive_regulation IL12B TLR7 20483758 2270103 Human intestinal lamina propria CD1c+ dendritic cells display an activated phenotype at steady state and produce [IL-23] in *response* to stimulation . Positive_regulation IL12B TLR7 20822377 2375342 Furthermore , the MDSC inhibited *induced* [IL-12] production of DC by IL-10 production and suppressed T cell stimulatory activity of DC . Positive_regulation IL12B TLR7 20840632 2363798 ligation by small chemical molecules will still *induce* interleukin-6 (IL-6) and tumour necrosis factor-a secretion , but not interferon-a or [IL-12] . Positive_regulation IL12B TLR7 20851125 2331471 Substitution of the acidic loop in TgPRF with the homologous loop from the apicomplexan parasite Cryptosporidium parvum does not affect *dependent* [IL-12] secretion , while substitution with the acidic loop from Plasmodium falciparum results in reduced but significant IL-12 secretion . Positive_regulation IL12B TLR7 21097503 2383200 A deficiency in functional UNC93B1 protein abolished *dependent* [IL-12] secretion by dendritic cells , attenuated Th1 responses against T. gondii , and dramatically enhanced susceptibility to the parasite . Positive_regulation IL12B TLR7 21106540 2389841 Mouse macrophages produce [IL-12] and IL-10 in *response* to ligands such as LPS , CpG , Poly I:C and Malp2 . Positive_regulation IL12B TLR7 21106540 2389891 The *induced* [IL-12] production was decreased , while that of IL-10 was increased by concurrent stimulation with a complement fragment C5a . Positive_regulation IL12B TLR7 21190998 2391277 In the present study , we show for the first time that IL-29 can increase *induced* [IL-12p40] production by human monocyte derived macrophages . Positive_regulation IL12B TLR7 21263070 2392661 PD-1 and SOCS-1 were found to associate by coimmunoprecipitation studies , and blocking PD-1 or silencing SOCS-1 in M/M ( F ) led to activation of STAT-1 during *stimulated* [IL-12] production . Positive_regulation IL12B TLR7 21741305 2490042 ligands of Lactobacillus sakei LK-117 isolated from seed mash for brewing sake are potent *inducers* of [IL-12] . Positive_regulation IL12B TLR7 22345668 2572038 Knockdown of hnRNP U expression greatly attenuated *induced* expression of TNF-a , IL-6 , and IL-1ß , but not [IL-12] , whereas hnRNP U overexpression greatly increased TLR induced expression of TNF-a , IL-6 , and IL-1ß . Positive_regulation IL12B TLR7 22440523 2600831 The expression of *induced* production of TNF-a , IFN-a , IL-6 , and [IL-12] were measured by multicolor flow cytometry . Positive_regulation IL12B TLR7 22536449 2590117 Here , we examine the *role* of and reactive oxygen species ( ROS ) in [IL-12] production by LAB stimulated peritoneal macrophages . Positive_regulation IL12B TLR7 22536449 2590157 Our results indicate that a is not *necessary* for [IL-12] induction by LAB , whilst the universal adaptor protein , MyD88 , is essential . Positive_regulation IL12B TLR7 22559913 2719171 While C5a indeed enhanced cytokine production of immature DCs , the addition of C5a inhibited production of IL-12 , [IL-23] and TNFa *induced* by various ligands such as LPS , R848 and Pam ( 3 ) CSK ( 4 ) . Positive_regulation IL12B TLR7 22685028 2659137 Type I and III interferons enhance IL-10R expression on human monocytes and macrophages , resulting in IL-10 mediated suppression of *induced* [IL-12] . Positive_regulation IL12B TLR7 22685028 2659169 This indicates that IFN-a increased the sensitivity of monocytes to IL-10 , and as a result , *induced* [IL-12p70] by IFN pretreated cells was suppressed . Positive_regulation IL12B TLR7 22685028 2659199 In summary , we demonstrate that one of the consequences of priming human APCs with IFN is to promote the cells ' sensitivity to IL-10 , which leads to the inhibition of *induced* [IL-12p70] production . Positive_regulation IL12B TLR7 22685319 2676011 Interestingly , despite expression of TLR mRNA on Kupffer cells , ligation of TLR4 , , and TLR9 *resulted* in a weak induction of IL-10 , low or undetectable levels of [IL-12p40] and TNF , and up-regulation of CD40 on the surface . Positive_regulation IL12B TLR7 22777843 2682023 We found here that was partially *required* for the induction of [IL-12] ( IL-12p70 ) by Candida albicans or Saccharomyces cerevisiae . Positive_regulation IL12B TLR7 22777843 2682026 Although RNA could also induce moderate *dependent* [IL-23] and tumor necrosis factor-alpha ( TNF-a ) secretion , TLR7 and other endosomal TLRs were redundant for IL-23 or TNF-a induction by whole fungi . Positive_regulation IL12B TLR7 22896020 2677825 The combination of ligands for and TLR3 *led* to synergistic secretion of both IL-23 and [IL-12p70] from all subjects ; Positive_regulation IL12B TLR7 22896633 2666493 p38 MAPK activation and IL-12p70 production was more robust from TFF2 ( -/- ) CD8+ DC compared with WT CD8+ DC and treatment of WT DC with rTFF2 suppressed *induced* [IL-12/23p40] production . Positive_regulation IL12B TLR7 23074227 2706663 Notably , the phosphoinositide 3-kinase (PI3K) pathway suppresses *induced* [IL-12] production as an auto-inhibitory regulator in dendritic cells . Positive_regulation IL12B TLR7 23074227 2706693 However , Okazaki et al. ( C5a controls *induced* IL-10 and [IL-12] production independent of phosphoinositide 3-kinase . Positive_regulation IL12B TLR7 23074227 2706713 2011 ; 149 : 265-274 ) recently indicated that PI3K activated downstream of C5a anaphylatoxin does not affect the *induction* of [IL-12] by , although C5a efficiently inhibits the induction , in macrophages . Positive_regulation IL12B TLR7 23080298 2745172 KCs lacking Tpl2 display defects with *induction* of cytokines interleukin (IL)-1ß , IL-10 , and [IL-23] . Positive_regulation IL12B TLR7 23246311 2732241 dependent *induction* of [IL-12] and IFN-a in pDCs led to production of IFN-? by NK cells . Positive_regulation IL12B TLR7 23504259 2809798 Adenosine signaling suppresses the *dependent* expression of TNF-a , [IL-12] , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Positive_regulation IL12B TLR7 23750720 2834117 In contrast to humans , pDC in rhesus macaques expressed the [interleukin (IL)-12p40] subunit in *response* to as well as TLR-9 stimulation . Positive_regulation IL12B TLR7 23755218 2797777 The aim of our study was to define the relative contribution of age and clinical status on *induced* [interleukin (IL)-12p70] and IL-23 production as these cytokines play an important role in the protection against intracellular and extracellular pathogens , respectively . Positive_regulation IL12B TLR7 23966630 2836165 Whereas TLR9 induced TNF-a secretion of bone marrow derived macrophages and conventional dendritic cells was equally inhibited by INH-ODN 2088 and G-modified INH-ODNs such as INH-ODN 24888 , *induced* TNF-a release and TLR7- and TLR9 induced [IL-12p40] release were significantly more impaired by G-modified INH-ODNs . Positive_regulation IL12B TLR7 24078692 2857912 In this study , we establish that , in addition to TLR11 , recognizes the profilin protein of the protozoan parasite Toxoplasma gondii and *regulates* [IL-12] production by DCs in response to the parasite . Positive_regulation IL12B TLR7 24078692 2857952 We also establish that the transcription factor IFN regulatory factor 8 , not NF-?B , plays a central role in the regulation of the TLR11- and *dependent* [IL-12] response of DCs . Positive_regulation IL12B TNF 10513808 651494 *restored* LPS stimulated [IL-12] production that had been inhibited by rolipram . Positive_regulation IL12B TNF 11013010 736267 In vitro [IL-12] production by Th1 type granuloma macrophages was *enhanced* by and IFNgamma , whereas lymphocyte IL-12 responsiveness was boosted only by TNF-alpha . Positive_regulation IL12B TNF 11157054 780718 Initial comparisons indicated that alpha induction of epithelial intercellular adhesion molecule 1 *required* sequential induction of [interleukin (IL)-12] ( p70 ) and interferon gamma , and unexpectedly localized IL-12 production to airway epithelial cells . Positive_regulation IL12B TNF 12010985 941367 These findings demonstrate that afferent-phase production is *essential* for the induction of [IL-12] and IFN-gamma and neutralization of early TNF-alpha results in a T2 shift of the T1/T2 balance of antifungal immunity . Positive_regulation IL12B TNF 12115630 964244 Colonic expression of IFN-gamma and was elevated ( 200- and 150-fold , respectively ) and IFN-gamma and [IL-12] secretion from lymph node cells was *increased* 5,000- and 8-fold , respectively , compared to GpG-ODN treated controls . Positive_regulation IL12B TNF 12207325 983556 We observed that ATPgammaS potentiated the [IL-12p40] release *induced* by , but also by lipopolysaccharides (LPS) and soluble CD40 ligand ( sCD40L ) . Positive_regulation IL12B TNF 12574344 1057858 TNF-alpha and RANKL cooperated with CD40L via differing mechanisms , i.e. , *enhanced* [IL-12] production , whereas RANKL enhanced survival of CD40L stimulated DCs . Positive_regulation IL12B TNF 1373169 183257 Thus , [IL-12] can directly influence NK cell activities in purified CD56+ cells , and endogenously produced is *involved* in mediating the effects of both IL-12 and IL-7 . Positive_regulation IL12B TNF 14670333 1188957 In an attempt to determine the *role* of IFN-gamma and in [IL-12] induced immunity , IFN-gamma and TNFR-p55 knockout mice were immunized with rSm14/IL-12 and no protection was achieved . Positive_regulation IL12B TNF 15683451 1370616 Polyriboinosinic polyribocytidylic acid ( Poly I:C ) + *induced* significant [IL-12] p70 secretion , which was increased after addition of a decoy IL-10 receptor . Positive_regulation IL12B TNF 16279537 1480578 In culture medium with ripe DC the levels of such cytokines as IL-1b , IL-6 , [IL-12] , IFN-gamma , significantly *increased* and the production of IL-4 decreased . Positive_regulation IL12B TNF 16307851 1526148 PGE ( 2 ) is synergistic with IL-1beta and in the induction of functional and phenotypic maturation of DC and *induce* [IL12] p40 production . Positive_regulation IL12B TNF 16522779 1531514 Interestingly , we found that when weakly IL-12- and *inducing* LAB and strong [IL-12-] and TNF-alpha inducing LAB were mixed , the weakly IL-12- and TNF-alpha inducing LAB efficiently inhibited otherwise strong IL-12- and TNF-alpha inducing LAB , yet when weakly IL-12- and TNF-alpha inducing LAB were mixed with G- bacteria , they synergistically induced IL-12 and TNF-alpha . Positive_regulation IL12B TNF 17058806 1636900 IL-1beta alone significantly induced IL-12 production in DCs , whereas or IFN-gamma *induced* modest levels of [IL-12] production . Positive_regulation IL12B TNF 17058806 1636909 These findings suggest that the p38 MAPK pathway is essential for the synergistic [IL-12] production *induced* by or IFN-gamma in combination with low-dose LPS in DC . Positive_regulation IL12B TNF 17619881 1815992 *induced* MIP-3alpha but not [IL-23] production in cultured synovial cells from RA patients . Positive_regulation IL12B TNF 17854477 1795903 These data indicate that CpG-ODN protects animals against lethal C. albicans challenge via a pathway that involves the dependent *induction* of [IL-12] . Positive_regulation IL12B TNF 18760623 1975406 *stimulated* secretion of [IL-12p40] was significantly increased by 30 min ; Positive_regulation IL12B TNF 19273561 2063315 YGPs stimulated secretion of the proinflammatory cytokine in wild-type murine bone marrow derived myeloid dendritic cells ( BMDCs ) but did not *stimulate* [interleukin-12p70 (IL-12p70)] production . Positive_regulation IL12B TNF 19607809 2123912 Both OA-NO ( 2 ) and LNO ( 2 ) prevented *stimulated* release of the cytokines , IL-6 , IL-8 , [IL-12/p40] , IFNgamma , MCP-1 , and IP-10 , and inhibited NF-kappaB activation . Positive_regulation IL12B TNF 19702865 2247683 rhamnosus *induced* higher levels of TNF-alpha , IL-6 and [IL-12] but inhibited IL-10 production , whereas its mucous variant induced low or no and IL-6 . Positive_regulation IL12B TNF 20428758 2247272 [IL-23] , which constitutively expressed in oral cancer , was *enhanced* by and IL-23 . Positive_regulation IL12B TNF 20822815 2346071 On day 12 , induction in monocyte derived macrophages and [IL-12] p40 *induction* in BAL macrophages infected with R. equi was significantly higher in foals treated with PPVO than in controls . Positive_regulation IL12B TNF 21472205 2361545 [IL-23] and its receptor mRNAs and proteins were spontaneously expressed , and IL-23 was *increased* by stimulation in the oral cancer cells . Positive_regulation IL12B TNF 21682792 2524003 Release of IL-6 and [IL-23] was *enhanced* less than twofold by the addition of AF while production was unchanged . Positive_regulation IL12B TNF 8097322 217614 We demonstrate that IFN-gamma production from SCID splenocytes is stimulated by [interleukin (IL) 12] , tumor necrosis factor alpha (TNF-alpha) , and IL-2 but is inhibited by IL-10 , IL-10 , IL-12 , and are *induced* by heat killed Listeria monocytogenes ( hk-LM ) from SCID splenocytes and peritoneal macrophages . Positive_regulation IL12B TNF 8683105 370237 [IL-12] and/or IL-6 can *induce* the expression of IL-10 by PHA stimulated T cells , whereas induces IL-10 production by monocytes . Positive_regulation IL12B TNF 8876217 390349 Interferon gamma , IL-10 , and could be *induced* throughout the treatment period by [IL-12] , indicating that repeated injections of IL-12 do not induce a state of tachyphylaxis . Positive_regulation IL12B TNF 8977306 403217 Furthermore , [IL-12] up-regulated TNF receptors on gammadelta T cells in vitro : binding to its receptor *induced* CD25 expression on the gammadelta T cells in an autocrine or paracrine fashion , or perhaps both . Positive_regulation IL12B TNF 9038291 415447 The production of IFN-gamma is *induced* by [IL-12] with as a costimulator and inhibited by IL-10 . Positive_regulation IL12B TNF 9573060 501925 The number of bacteria in the macrophages infected with 103- and HK decreased progressively , whereas the 103+ numbers remained constant over 48 h . Interleukin 1beta (IL-1beta) , IL-6 , IL-10 , [IL-12] p40 , and mRNA *induction* peaked at 4 h and returned to baseline between 12 and 48 h postinfection . Positive_regulation IL12B TNF 9647251 514993 The expression of both [IL-12] protein and mRNAs for the p35 and p40 IL-12 subunits was strongly induced in all donors by the Th2-like cytokines IL-4 and granulocyte-macrophage CSF and was also moderately *induced* by and IL-1alpha . Positive_regulation IL12B TNF 9806041 544746 protein expression occurred earlier than IL-12 p40 protein but was not *required* for [IL-12] induction . Positive_regulation IL12B TNF 9848688 554042 Whether these lipid A-common Re595 LPS preparations differed in activities , we investigated their effects on nitric oxide ( NO ) , , IL-6 , and [IL-12] *induction* from murine macrophage cell line RAW 264.7 . Positive_regulation IL12B TNF 9916686 587478 Based on previous work that suggests that the production of [IL-12] by activated human central nervous system derived microglia is *regulated* by autocrine , we wanted to determine whether inhibition of TNF could induce a reduction of Th1 responses by its impact on systemic APCs . Positive_regulation IL12B TNFSF10 11774735 890602 Consisting with this finding , [IL-12] and NKT cell specific ligand , alpha-Galactosylceramide ( alpha-GalCer ) , *induced* TRAIL mediated cytotoxcity and anti-tumor effect , and which was mediated by expressed on IFN-gamma activated NK cells . Positive_regulation IL12B TP63 16249388 1518251 Hydrogen peroxide inhibits [IL-12] *induction* in macrophages by inhibiting c-rel translocation to the nucleus through activation of calmodulin protein . Positive_regulation IL13 ABCG2 20846001 2375396 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL13 CCL17 15219001 1263900 In peripheral mononuclear cells from atopic donors , CCL22 and were *induced* by IL-4 and [IL-13] , further supporting the relationship between CCL22/CCL17 and Th2 cytokines . Positive_regulation IL13 CCL17 22057112 2540315 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL13 CCL17 24704819 2938796 Both [IL-13] and IL-4 dose-dependently *induce* production from J774 mouse monocytic cells and CCL11 production from NIH3T3 mouse fibroblasts in the presence of TNFa . Positive_regulation IL13 CTGF 21804025 2467674 [IL-13] *induces* in rat hepatic stellate cells via TGF-ß independent Smad signaling . Positive_regulation IL13 CTGF 22593760 2598996 In vitro , [IL-13] directly *induces* expression of fibrosis associated genes , e.g. , collagens or , in hepatic stellate cells . Positive_regulation IL13 DAPK1 24220855 2897416 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL13 EPHB2 11880312 919369 [IL-13] and IL-4 cause eotaxin release in human airway smooth muscle cells : a *role* for . Positive_regulation IL13 EPHB2 12609986 1085291 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL13 EPHB2 18310510 1904087 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL13 EPHB2 19135025 2037660 The EGCG induced mRNA up-regulation of IL-2 and IL-5 was predominantly affected by the extracellular signal regulated protein kinase ( ERK ) signalling , whereas [IL-13] gene expression , the most responsive to the EGCG treatment , was *dependent* on neither nor c-jun NH ( 2 ) -terminal kinase ( JNK ) signalling . Positive_regulation IL13 F3 7635444 317252 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL13 IL1B 14617515 1200636 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL13 IL1B 15191916 1280935 The *induction* of [IL-13] and MCP-1 gene expression by was accompanied by the activation of IL-1 receptor associated kinase and translocation of the transcription factor , nuclear factor (NF) kappaB into the nucleus . Positive_regulation IL13 IL1B 15191916 1280937 Accordingly , Bay-11 7082 , an inhibitor of NF-kappaB activation , inhibited *induced* [IL-13] and MCP-1 expression . Positive_regulation IL13 IL1B 15191916 1280938 also *induced* [IL-13] promoter activity while enhancing the stability of IL-13 messenger RNA transcripts . Positive_regulation IL13 IL1B 15383152 1304179 However , IL-6 , IL-8 , and [IL-13] production *induced* by were significantly enhanced by addition of epinephrine . Positive_regulation IL13 IL1B 16375968 1547125 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL13 IL1B 17700564 1794525 IL-33 or also *induced* IL-8 and [IL-13] production in naïve HUCBMCs , and enhanced production of these cytokines in IgE/anti-IgE stimulated HUCBMCs , without enhancing secretion of either PGD ( 2 ) or histamine . Positive_regulation IL13 IL1B 17881510 1823676 We found that IL-33 , but not or IL-18 , *induced* [IL-13] and IL-6 production by mouse bone marrow derived , cultured mast cells ( BMCMCs ) independently of IgE . Positive_regulation IL13 IL1B 17881510 1823689 In BMCMCs incubated with the potently cytokinergic SPE-7 IgE without specific antigen , IL-33 , , and IL-18 each *promoted* [IL-13] and IL-6 production , but the effects of IL-33 were more potent than those of IL-1beta or IL-18 . Positive_regulation IL13 IL1B 8874201 389946 Furthermore , although some [IL-13] is produced in response to C5a in the *presence* of IL-5 , GM-CSF , IGF-1 or , IL-3 is by far the most effective . Positive_regulation IL13 IL1B 9550283 477746 For this purpose rat pancreatic islets were cultured in medium RPMI 1640 + 10 % fetal calf serum and exposed for 42 h to human [IL-13] ( 0. 0.1 , 1 and 10 ng/ml ) in the *presence* or absence of human ( 25 U/ml ) during the last 24 h of culture . Positive_regulation IL13 IL1R2 8387521 218020 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL13 MUC16 11133503 769162 [IL-13] *induces* production by stimulating epidermal growth factor receptors and by activating neutrophils . Positive_regulation IL13 PGC 22117073 2535010 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL13 SRGN 15450130 1300673 Stimulation with *induced* the secretion of both [IL-13] and IFN-gamma , influenced by time and dose in neonates , adults , and mice . Positive_regulation IL13 STAT4 15728489 1377242 The IL-2-plus-IL-18 or IL-12-plus-IL-18 effect on IFN-gamma and [IL-13] expression is *dependent* on and NF-kappaB but independent of Stat6 , T-bet , or NFAT . Positive_regulation IL13 STAT4 7638186 317675 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL13 TLR7 12045249 950115 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL13 TLR7 18312842 1879326 Toxoplasma profilin is essential for host cell invasion and dependent *induction* of an [interleukin-12] response . Positive_regulation IL13 TLR7 20632067 2367995 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in mediated *activation* of caspase 1 and [interleukin-1ß] . Positive_regulation IL13 TLR7 22521509 2613509 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL13 TLR7 23246311 2732021 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL13 TNF 10030846 591967 However , eosinophil viability and CD69 expression increased synergistically when eosinophils were incubated with [IL-13] or IL-4 in the *presence* of . Positive_regulation IL13 TNF 10820380 694464 We show that [IL-13] in the *presence* of effected an equal or greater antiviral activity against a dual-tropic HIV-1 ( R5X4 ) in macrophages . Positive_regulation IL13 TNF 11880312 919375 U-0126 also inhibited [IL-13] , and *induced* mRNA expression . Positive_regulation IL13 TNF 1463043 206750 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL13 TNF 17854477 1795887 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving dependent [interleukin-12] *induction* . Positive_regulation IL13 TNF 17944748 1814249 does *increase* transcription of both IFN-gamma and [IL-13] in vitro but can also act synergistically with IL-13 in vitro to promote production of RELMbeta , which has also been shown to play a role in resistance to T. muris . Positive_regulation IL13 TNF 18554706 1959087 , elicited either by allergen exposure or pulmonary overexpression , *induced* SP-D , [IL-13] , and mononuclear cell influx in the lung . Positive_regulation IL13 TNF 2113076 135542 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL13 TNF 21745554 2471907 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL13 TNF 21893119 2506520 Conversely , activation of caspase by exogenous *required* [IL-13] , TWEAK , and Fn14 . Positive_regulation IL13 TNF 2370931 138345 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL13 TNF 24879793 2945828 IL-13Ra2 expression can be *induced* in lung fibroblasts by IL-4 or [IL-13] via a STAT6 dependent mechanism , or by via a STAT6 independent mechanism . Positive_regulation IL13 TNF 3011946 59754 Tumor necrosis interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL13 TNF 3486658 59953 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL13 TNF 3486658 60007 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL13 TNF 3486936 60096 Tumor necrosis factor ( ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL13 TNF 3500495 80705 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL13 TNF 3526909 62646 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL13 TNF 7506142 237742 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL13 TNF 7737374 305514 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL13 TNF 8132326 251520 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL13 TNF 8592105 341910 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL13 TNF 8592105 341965 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL13 TNF 8910536 395207 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL13 TNF 9162077 431917 Whereas LPS induced TNF-alpha production is strongly suppressed by both cytokines , mRNA accumulation is not significantly affected , indicating that IL-4 and [IL-13] *induce* a translational repression of TNF-alpha mRNA . Positive_regulation IL13RA2 TNF 18451175 1902917 Furthermore , acting on prior studies showing that [IL-13R alpha(2)] expression is *induced* ( in part ) by , we show that receptor expression and TGF-beta(1) production is inhibited by administration of a TNF-alpha neutralizing substance , TNF-alpha R-Fc ( etanercept ) . Positive_regulation IL15 ABCG2 20846001 2375397 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL15 CCL17 22057112 2540316 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL15 DAPK1 24220855 2897419 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL15 EPHB2 12609986 1085292 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL15 EPHB2 18310510 1904093 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL15 F3 7635444 317255 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL15 IL1B 11219394 763951 and TNF-alpha also *induce* [IL-15] in fibroblast like synoviocytes , which induces the production of IL-17 which in turn potentiates IL-1beta and TNF-alpha production in monocyte-macrophages . Positive_regulation IL15 IL1B 11817607 908161 In a semiquantitative PCR , CSA increased IL-10 mRNA expression but strongly suppressed *induced* [IL-15] and TNFalpha mRNA expression , indicating that the production of these cytokines by CSA was regulated at the transcriptional level . Positive_regulation IL15 IL1B 12627325 1066908 and IFN-gamma *induce* the expression of diverse chemokines and [IL-15] in human and rat pancreatic islet cells , and in islets from pre-diabetic NOD mice . Positive_regulation IL15 IL1B 14617515 1200637 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL15 IL1B 14967219 1209136 These results suggest that ovarian steroid hormones and *regulate* [IL-15] mRNA expression and protein production in long-term culture , and that IL-1beta plays a role as a negative regulator of IL-15 production during decidualization in human endometrium . Positive_regulation IL15 IL1B 16375968 1547126 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL15 IL1B 9717664 528115 [IL-15] protein was detected in cellular lysates of unstimulated cells and was *increased* by stimulation with TNF-alpha or . Positive_regulation IL15 IL1R2 8387521 218022 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL15 ITGB2 11449367 836568 Furthermore , we also demonstrated that IL-2 , IL-7 and [IL-15] could *induce* de novo the synthesis of and CD2 . Positive_regulation IL15 PGC 22117073 2535011 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL15 STAT4 7638186 317676 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL15 STAT4 9574535 502534 Moreover , we showed that this increase in IFN-gamma could be explained by the dual *activation* of STAT1 and by [IL-15] and IL-12 , respectively . Positive_regulation IL15 TLR7 12045249 950116 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL15 TLR7 15880118 1411387 DC-SIGN+ phagocytic macrophages were expanded by *mediated* upregulation of [interleukin (IL)-15] and IL-15 receptor . Positive_regulation IL15 TLR7 18312842 1879340 Toxoplasma profilin is essential for host cell invasion and dependent *induction* of an [interleukin-12] response . Positive_regulation IL15 TLR7 20632067 2367997 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in mediated *activation* of caspase 1 and [interleukin-1ß] . Positive_regulation IL15 TLR7 22521509 2613519 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL15 TLR7 23246311 2732035 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL15 TNF 10725717 677633 Moreover , lamina propria T cells ( LP-T ) from IBD patients were more responsive to IL-15 as compared with controls , and [IL-15] alone without a primary T cell stimulus *induced* IFN-gamma and production by isolated IBD LP-T cells , especially by LP-T cells from patients with Crohn 's disease . Positive_regulation IL15 TNF 10969796 728398 IL-10 decreased the production of IL-6 and the expression of IL-12 in the *presence* of or sCD40L , but it had no effect on [IL-15] , IL-18 , and TNF-alpha secretion . Positive_regulation IL15 TNF 11219394 763950 IL-1beta and also *induce* [IL-15] in fibroblast like synoviocytes , which induces the production of IL-17 which in turn potentiates IL-1beta and TNF-alpha production in monocyte-macrophages . Positive_regulation IL15 TNF 11741746 897692 Similarly , also *caused* a moderate increased expression of different anti-inflammatory cytokines such as IL-9 ( 104 % ) , IL-10 ( 24 % ) and [IL-15] ( 47 % ) . Positive_regulation IL15 TNF 12147628 970073 Myoblasts constitutively produced a low level of [IL-15] and the production was *augmented* by stimulation with IFN-gamma , IL-1alpha , IL-1beta , or lipopolysaccharide (LPS) in a dose dependent manner . Positive_regulation IL15 TNF 12928391 1132003 [IL-15] strongly *induces* production in SOCS1-deficient CD8+ T cells , indicating that SOCS1 is also a critical regulator of CD8+ T cell activation by IL-15 . Positive_regulation IL15 TNF 1463043 206752 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL15 TNF 15735428 1378427 [IL-15] , in the absence of Io + PMA , did not *induce* the expression of IFN-gamma , , or IL-2R alpha . Positive_regulation IL15 TNF 17854477 1795888 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving *dependent* [interleukin-12] induction . Positive_regulation IL15 TNF 19559672 2110574 augmented the IL-15 induced expression of NK1 .1 and CD122 in mature NK cells , and TNF-alpha alone also *induced* NK cell maturation as well as [IL-15] . Positive_regulation IL15 TNF 19559672 2110580 also *increased* IFN-gamma production in NK cells in the presence of [IL-15] . Positive_regulation IL15 TNF 20062995 2225446 *induced* production of IP-10 , but not [IL-15] in cultured synovial cells from RA patients . Positive_regulation IL15 TNF 2113076 135543 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL15 TNF 21745554 2471909 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL15 TNF 2370931 138346 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL15 TNF 23950892 2831596 *stimulates* nuclear export and secretion of [IL-15] by acting on CRM1 and ARF6 . Positive_regulation IL15 TNF 23950892 2831598 In the *presence* of , LMB co-treatment led to accumulation of both [IL-15Ra] and IL-15 in the nucleus of HeLa cells , suggesting that CRM1 facilitates nuclear export and that TNF enhances CRM1 activity . Positive_regulation IL15 TNF 23950892 2831599 The *induced* secretion of [IL-15] was attenuated by pretreatment of cells by brefeldin A that inhibits ER-to-Golgi transport , or by use of domain negative ADP-ribosylation factor 6 (ARF6) that interferes with exocytotic sorting . Positive_regulation IL15 TNF 3011946 59755 interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL15 TNF 3486658 59954 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL15 TNF 3486658 60008 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL15 TNF 3486936 60097 ( cachectin ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL15 TNF 3500495 80706 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL15 TNF 3526909 62647 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL15 TNF 7506142 237743 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL15 TNF 7737374 305515 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL15 TNF 8132326 251521 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL15 TNF 8592105 341911 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL15 TNF 8592105 341966 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL15 TNF 8910536 395208 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL15 TNF 8921231 396776 Both non transformed and SV-40 transformed human fetal RPE cells express [IL-15] , a T cell growth factor which has similar biological activities to IL-2 , and the expression of IL-15 is *enhanced* by interferon-gamma (IFN-gamma) or stimulation . Positive_regulation IL15 TNF 9018238 412193 We now report that [interleukin-15 (IL-15)] can *induce* production in RA through activation of synovial T cells . Positive_regulation IL15 TNF 9376592 465508 [IL-15] also significantly *induced* interferon-gamma (IFN-gamma) and protein production ( days 1 , 3 , and 6 , P < .05 , n = 3 ) in CB MNCs . Positive_regulation IL15 TNF 9717664 528114 [IL-15] protein was detected in cellular lysates of unstimulated cells and was *increased* by stimulation with or IL-1 beta . Positive_regulation IL15RA JAG1 9574535 502520 We therefore studied the [IL-15R alpha] chain expression in human gamma delta T cells in the *presence* or absence of nonpeptide . Positive_regulation IL15RA TLR7 19369481 2089027 Porcine NK cells express both and TLR8 mRNAs , and treatment with these TLR agonists *induced* higher mRNA expression levels of TRAIL and [IL-15Ralpha] , which may contribute to the activity of NK cells . Positive_regulation IL16 ABCG2 20846001 2375398 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL16 CCL17 22057112 2540317 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL16 DAPK1 24220855 2897422 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL16 EPHB2 12609986 1085293 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL16 EPHB2 18310510 1904099 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL16 F3 7635444 317258 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL16 IL1B 10725741 677646 The *induction* of [IL-16] protein by can be attenuated with specific inhibition of caspase-3 , which could be detected in IL-1beta treated fibroblasts . Positive_regulation IL16 IL1B 11509331 848303 [IL-16] release was increased in a concentration dependent manner by *stimulation* with or TNF-alpha . Positive_regulation IL16 IL1B 14617515 1200638 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL16 IL1B 15560757 1341036 Stimulation of day 8 DCs from AD patients with TNF-alpha and enhanced the expression of CD83 and CD86 and *restored* the production of [IL-16] . Positive_regulation IL16 IL1B 16375968 1547127 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL16 IL1R2 8387521 218024 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL16 PGC 22117073 2535012 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL16 STAT4 7638186 317677 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL16 TLR7 12045249 950117 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL16 TLR7 18312842 1879354 Toxoplasma profilin is essential for host cell invasion and dependent *induction* of an [interleukin-12] response . Positive_regulation IL16 TLR7 20632067 2367999 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in mediated *activation* of caspase 1 and [interleukin-1ß] . Positive_regulation IL16 TLR7 22521509 2613529 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL16 TLR7 23246311 2732049 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL16 TNF 10572065 568674 IL-16 expression was significantly upregulated in a concentration dependent manner within 24 h by stimulation with histamine , IL-1beta , or whereas interferon-gamma did not significantly *increase* [IL-16] . Positive_regulation IL16 TNF 11509331 848302 [IL-16] release was *increased* in a concentration dependent manner by stimulation with IL-1 beta or . Positive_regulation IL16 TNF 12594062 1060730 *induced* synthesis of [interleukin-16] in airway epithelial cells : priming for serotonin stimulation . Positive_regulation IL16 TNF 1463043 206754 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL16 TNF 15560757 1341032 Stimulation of day 8 DCs from AD patients with and IL-1beta enhanced the expression of CD83 and CD86 and *restored* the production of [IL-16] . Positive_regulation IL16 TNF 17854477 1795889 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving dependent [interleukin-12] *induction* . Positive_regulation IL16 TNF 2113076 135544 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL16 TNF 21745554 2471911 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL16 TNF 2370931 138347 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL16 TNF 3011946 59756 Tumor necrosis interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL16 TNF 3486658 59955 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL16 TNF 3486658 60009 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL16 TNF 3486936 60098 Tumor necrosis factor ( ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL16 TNF 3500495 80707 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL16 TNF 3526909 62648 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL16 TNF 7506142 237744 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL16 TNF 7737374 305516 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL16 TNF 8132326 251522 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL16 TNF 8592105 341912 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL16 TNF 8592105 341967 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL16 TNF 8910536 395209 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL16 TP63 19100623 2031202 IL-12 homodimer , but not IL-12 p70 , *induces* the expression of [IL-16] in microglia and macrophages . Positive_regulation IL17A ADAMTS1 23977238 2832977 Moreover , in cultured cardiac fibroblasts , [IL-17A] *induced* the expression of , MMP-2 , and collagen subtypes I and III and increased the proliferation of fibroblasts . Positive_regulation IL17A CAPN8 22046434 2503855 We found that the calpastatin-calpain balance varied during Th1 , Th2 , and Th17 development , and that overexpression of a minimal domain of calpastatin ( by retroviral gene transduction ) or the inhibition of by E-64-d *suppressed* the production of IL-6 and [IL-17] by Th cells and the production of IL-6 by fibroblasts . Positive_regulation IL17A EPHB2 10833473 697762 Inhibition of activation with the MEK inhibitor PD98059 *blocked* [IL-17] as well as basal development of tight junctions in T84 cells . Positive_regulation IL17A EPHB2 18310510 1904187 HG induces phosphoinositide 3- kinase [ PI3K ; inhibited by adenoviral ( Ad ) .dominant negative ( dn ) PI3Kp85 ] , Akt ( inhibited by Ad.dnAkt1 ) , and ( inhibited by PD-98059 ) activation and *induces* [IL-17] expression via PI3K -- > Akt -- > ERK dependent signaling . Positive_regulation IL17A EPHB2 18310510 1904191 Pretreatment with the phytoalexin resveratrol blocks HG-induced PI3K- , Akt- , and *dependent* [IL-17] expression . Positive_regulation IL17A EPHB2 20299682 2293743 The MAPK , known to mediate transcription of IL-1beta mRNA , was strongly *involved* in the [IL-17A] production induced by MTB . Positive_regulation IL17A HES2 20876311 2337321 *induced* [IL-17] in the presence of IL-6 but did not promote Th1 or Th2 development under any conditions . Positive_regulation IL17A IL1B 12064845 953424 [Interleukin 17 (IL-17)] *induces* collagenase-3 production in human osteoarthritic chondrocytes via AP-1 dependent activation : differential activation of AP-1 members by IL-17 and . Positive_regulation IL17A IL1B 16818675 1586238 IL-23 alone did not induce IL-17 production by T cells from IL-1RI ( -/- ) mice , and IL-23 induced [IL-17] production was substantially *enhanced* by IL-1alpha or , even in the absence of T cell receptor stimulation . Positive_regulation IL17A IL1B 17384030 1715805 [IL-17] was less potent as a direct MMP inducer than IL-1beta and TNF-alpha , but it *induced* and TNF-alpha production from macrophages , and IL-6 and IL-8 from gingival fibroblasts . Positive_regulation IL17A IL1B 18454151 1915995 We show here that TGF-beta , and IL-6 , IL-21 or IL-23 in serum-free conditions were necessary and *sufficient* to induce [IL-17] expression in naive human CD4+ T cells from cord blood . Positive_regulation IL17A IL1B 18469800 1933218 Here we confirm that whereas and IL-6 *induce* [IL-17A] secretion from human central memory CD4 ( + ) T cells , TGF-beta and IL-21 uniquely promote the differentiation of human naive CD4 ( + ) T cells into T ( H ) 17 cells accompanied by expression of the transcription factor RORC2 . Positive_regulation IL17A IL1B 18512782 1922474 and IL-6 independently induced IL-21 secretion , but the presence of IL-21 alone was not *sufficient* for [IL-17] production . Positive_regulation IL17A IL1B 18523258 1922795 alone or in association with IL-23 and IL-6 markedly increase IL-17 ( + ) CCR6 ( + ) memory T cells and *induce* [IL-17] production in CCR6 ( - ) memory T cells . Positive_regulation IL17A IL1B 18786965 1976028 On the other hand , TNF-alpha and [IL-17] did not *induce* RANKL expression , although TNF-alpha , IL-17 or stimulated cell growth and IL-6 production . Positive_regulation IL17A IL1B 18958872 1982868 Furthermore , IL-1alpha or in synergy with IL-23 can *promote* [IL-17] secretion from memory T cells . Positive_regulation IL17A IL1B 19056110 2023923 [IL-17] secretion was not *enhanced* by IL-23 , , or IL-6 but was enhanced by the S aureus derived superantigen staphylococcal enterotoxin B . Positive_regulation IL17A IL1B 19161420 2007014 IL-23 , IL-6 , transforming growth factor ( TGF-beta1 ) , and in supernatants from activated human DCs *induce* human naive CD4 ( + ) T cells to produce [IL-17] . Positive_regulation IL17A IL1B 19535637 2098915 In addition , gammadelta T cells are also targets of this cytokine , contributing to *mediated* production of [IL-17] . Positive_regulation IL17A IL1B 19644886 2118684 Furthermore , [IL-17] production by gamma/delta T cells was *induced* by plus IL-23 independently of T cell receptor . Positive_regulation IL17A IL1B 19666510 2125975 Similarly , Th17 cells produce [IL-17A] in *response* to and a STAT3 activator and Th1 cells produce IFNgamma in response to IL-18 and a STAT4 inducer . Positive_regulation IL17A IL1B 19682929 2126268 Here , we show that gammadelta T cells express IL-23R and the transcription factor RORgammat and produce [IL-17] , IL-21 , and IL-22 in *response* to and IL-23 , without T cell receptor engagement . Positive_regulation IL17A IL1B 19740775 2163252 IL23 and plus IL6 *had* no effect on IBD LPMC production of [IL17] ; Positive_regulation IL17A IL1B 19965648 2199546 Furthermore , [IL-17] production from the cytokine treated naive CD4 ( + ) T cells was *induced* by and this induction was blocked by IL-1R antagonist . Positive_regulation IL17A IL1B 20479237 2269538 Furthermore , [IL-17] is involved in the induction of serum and mucosal antibody responses by CT. Th17 cells induced by CT have a unique cytokine profile compared with those induced by IL-6 and TGF-beta , and their induction by CT *requires* cAMP dependent secretion of and beta-calcitonin gene related peptide by dendritic cells . Positive_regulation IL17A IL1B 20534450 2279262 promoted constitutive IL-22 secretion rather than acute IL-22 production in response to IL-23 and *induced* [IL-17] in some cells . Positive_regulation IL17A JAG1 20083670 2206015 Splenocytes isolated from mice infected by the transurethral route robustly expressed [IL-17A] in *response* to in vitro stimulation with uropathogenic E. coli . Positive_regulation IL17A JAG1 21490151 2422912 In this article , we demonstrate that LT acts as a highly effective adjuvant when administered parenterally , promoting Ag-specific [IL-17] , as well as IFN-? , IL-4 , and IL-10 production in *response* to coadministered . Positive_regulation IL17A JAG1 21918192 2491974 tumor rejection requires [IL-17] , which is produced by IFN-?-deficient CD4 ( + ) T cells in *response* to tumor ( TAs ) . Positive_regulation IL17A MAP2K6 10555036 565689 Within minutes , [IL-17] *induced* the phosphorylation of ( MEK-1/2 ) , -3/6 ( MKK-3/6 ) , p44/42 , p38 , and inhibitor of nuclear factor kappaB ( I kappaB)-alpha , as well as the activation of mitogen activated protein kinase activated protein kinase-1 and -2 ( MAPKAPK-1 and -2 ) . Positive_regulation IL17A MIP 20957005 2333528 [IL-17] was produced early in airway upon Chlamydia trachomatis , and rmIL-17could *induce* IL-6 and production in L929 cells after infection with MoPn . Positive_regulation IL17A MIP 23614243 2774774 The production of Th17 associated cytokines/chemokines such as IL-6 , [IL-17] , KCand *increased* , which peaked on day 7 post-infection , then gradually reduced . Positive_regulation IL17A MMP28 18203309 1876448 Increased [IL-17] levels in ERA SF correlate with disease activity and this may be *due* to increased production of and cytokines by IL-17 . Positive_regulation IL17A MMP7 18203309 1876463 Increased [IL-17] levels in ERA SF correlate with disease activity and this may be *due* to increased production of and cytokines by IL-17 . Positive_regulation IL17A PTGER2 21059767 2349511 Stimulation with PGE2 or agonists *restored* [IL-17] production . Positive_regulation IL17A RNASE7 23555696 2767382 [IL-17A] and IFN-? synergistically *induce* expression via STAT3 in primary keratinocytes . Positive_regulation IL17A RNASE7 23555696 2767384 Therefore we investigated the influence of STAT3 on the [IL-17A/IFN-?] -mediated *induction* . Positive_regulation IL17A RNASE7 23555696 2767386 The use of a STAT3 inhibitor as well as siRNA mediated downregulation of STAT3 resulted in a diminished [IL-17A/IFN-?] -mediated *induction* in keratinocytes indicating that STAT3 is involved in this process . Positive_regulation IL17A RORC 20200272 2229573 Furthermore , we demonstrated in vitro that mast cells produced *dependent* [IL-17A] upon stimulation with TNF-alpha , IgG complexes , C5a , and LPS . Positive_regulation IL17A STAT4 17404271 1721930 We further show that is partially required for the development of IL-23- , but not TGFbeta1 plus IL-6 primed IL-17 secreting cells , and is absolutely *required* for [IL-17] production in response to IL-23 plus IL-18 . Positive_regulation IL17A STAT4 23001997 2702213 Consistent with the idea that *regulates* the production of [interleukin-17 (IL-17)] and interferon-? , IL17 messenger RNA and protein levels were increased in individuals carrying the rs897200 risk genotype AA . Positive_regulation IL17A TLR7 17919942 1819517 MDP enhanced obligate bacterial agonist induction of IL-23 and IL-1 , which *promoted* [IL-17] expression in T cells . Positive_regulation IL17A TNF 17384030 1715804 [IL-17] was less potent as a direct MMP inducer than IL-1beta and TNF-alpha , but it *induced* IL-1beta and production from macrophages , and IL-6 and IL-8 from gingival fibroblasts . Positive_regulation IL17A TNF 17982105 1821082 In vitro , [IL-17A] , IL-17B , IL-17C , and IL-17F *induced* production in mouse peritoneal exudate cells . Positive_regulation IL17A TNF 19487306 2115723 Blocking of activity *inhibits* TCR mediated activation and [IL-17] production . Positive_regulation IL17A TNF 20200272 2229574 Furthermore , we demonstrated in vitro that mast cells produced RORC dependent [IL-17A] upon *stimulation* with , IgG complexes , C5a , and LPS . Positive_regulation IL17A TNF 20630498 2304575 The expression of COX-2 , IL-1alpha , IL-6 , IL-8 , IL-11 , and , as well as PGE ( 2 ) production *increased* in the presence of [IL-17A] , whereas COX-1 expression did not change . Positive_regulation IL17A TNF 21402950 2411941 from inflammatory dendritic cells (DCs) *regulates* lung [IL-17A/IL-5] levels and neutrophilia versus eosinophilia during persistent fungal infection . Positive_regulation IL17A TNF 21507574 2453728 [IL-17] was found to induce hyperalgesia , but this was *dependent* on neutrophil migration and binding to TNF receptor 1 (TNFR1) . Positive_regulation IL17A TNF 22136309 2557846 In terms of local cytokine network in the skin , [IL-17A] dramatically *induced* IL-1ß , IL-6 , and production in skin-resident cells such as keratinocytes and fibroblasts . Positive_regulation IL17A TNF 22219138 2563806 These data show that blockade does not *suppress* [IL-17A] and IL-22 , which can be overcome by 1,25 ( OH ) ( 2 ) D ( 3 ) . Positive_regulation IL17A TNF 22582749 2614284 and antiseptic therapies prevented the development and exacerbation of infectious-PD. Anti-TNF-a therapy also *resulted* in reduced expression of IFN-? , TNF-a and [IL-17] in maxillae . Positive_regulation IL17A TNF 23627571 2810510 We evaluated IL-17 using immunolocalization in herniated and non herniated human discs , IL-17 gene expression , and the production of [IL-17] by annulus cells cultured in three dimensions in the *presence* of IL-1ß or . Positive_regulation IL17A TNF 24927559 2946762 is not *required* for [IL-17A] secretion by ILCs in vitro but synergizes with IL-17A to induce the expression of neutrophil attracting chemokines . Positive_regulation IL17C TNF 17982105 1821083 In vitro , IL-17A , IL-17B , [IL-17C] , and IL-17F *induced* production in mouse peritoneal exudate cells . Positive_regulation IL17D EPHB2 24434636 2922586 While p38 and JNK did not seem to play a role in the modulation properties of S1P on cytokine production , is at least partially *involved* in the S1P mediated modulation of IL-12 and [IL-27] . Positive_regulation IL17D PTGER2 15486065 1366922 Interestingly , the reciprocal regulation of [IL-12/IL-27] and IL-23 by ATP was mediated by 2 distinct P2 receptors and was also *induced* by prostaglandin E ( 2 ) by cyclic adenosine monophosphate ( cAMP ) -elevating receptors . Positive_regulation IL17D TLR7 17548596 1752129 [IL-27] synthesis *induced* by ligation critically depends on IFN regulatory factor 3 . Positive_regulation IL17D TLR7 17684041 1805572 We report that *dependent* expression of [IL-27] in human macrophages is mediated by IFN-alpha . Positive_regulation IL17D TLR7 19265172 2045536 expression was also *necessary* for the IFN-beta1a induced inhibition of IL-1beta and IL-23 and the induction of [IL-27] secretion by DCs . Positive_regulation IL17D TLR7 20083668 2205996 Critical role of the IFN stimulated gene factor 3 complex in *mediated* [IL-27p28] gene expression revealing a two-step activation process . Positive_regulation IL17D TNF 20971923 2348631 In this study , we found that [IL-27] production is *induced* by in human macrophages ( MF ) and investigated the effects of IL-27 on the responses of primary human MF to the endogenous inflammatory cytokines TNF-a and IL-1 . Positive_regulation IL17F IL1B 19170127 2049005 Concomitant administration of Dex , a known NF-kappaB inhibitor , resulted in significantly down-regulated *induced* NF-kappaB/p65 activity , as well as reduced expression of chemokine receptors and [IL-17F] in mouse prostate tissue . Positive_regulation IL17F TNF 17982105 1821081 In vitro , IL-17A , IL-17B , IL-17C , and [IL-17F] *induced* production in mouse peritoneal exudate cells . Positive_regulation IL17F TNF 18411338 1907781 We show that like IL-17 , [IL-17F] regulates proinflammatory gene expression in vitro , and this *requires* IL-17 receptor A , receptor associated factor 6 , and Act1 . Positive_regulation IL17RA TLR7 25076485 2956791 Taken together , we concluded that signaling can directly *stimulate* the expression of [IL-17RA] , but not IL-17RC , in neuroglial cells , which functionally respond to IL-17A by secreting chemokines , accelerating CD4 cell migration , and contributing to the pathogenesis of encephalomyelitis . Positive_regulation IL17RB TNF 16428271 1554352 Our data indicate that *upregulates* [IL-17BR] mainly through nuclear factor-kappaB as assessed with the IkappaB kinase 2 inhibitor AS-602868 . Positive_regulation IL17RB TNF 16428271 1554353 In addition , both IFN-gamma and dexamethasone are able to antagonize a *induced* [IL-17BR] increase in mRNA expression . Positive_regulation IL17RC TLR7 25076485 2956781 Taken together , we concluded that signaling can directly *stimulate* the expression of IL-17RA , but not [IL-17RC] , in neuroglial cells , which functionally respond to IL-17A by secreting chemokines , accelerating CD4 cell migration , and contributing to the pathogenesis of encephalomyelitis . Positive_regulation IL17RC TNF 23648353 2779702 Methylprednisolone caused a marked attenuation of *induced* [IL-17RC] expression ( 0.333 ± 0.031 vs 0.660 ± 0.026 , F = 89.637 , P < 0.05 ) . Positive_regulation IL17RD EPHB2 21663947 2459792 We found that the [hSef] expression was positively *regulated* by FGF2 induced signaling and inversely , hSef expression efficiently inhibited the activity of FGF2 induced MAPK/ERK signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Positive_regulation IL18 ABCG2 20846001 2375399 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL18 CCL17 22057112 2540318 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL18 CD14 11097749 755797 LPS mediated [IL-18] gene expression and secretion was *dependent* and significantly inhibited by co-incubation of PBMC with neutralizing CD14 antibody ( P < 0.01 ) . Positive_regulation IL18 DAPK1 24220855 2897425 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL18 EPHB2 12609986 1085294 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL18 EPHB2 18310510 1904105 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL18 EPHB2 19688743 2175829 *Activation* of p38 MAP kinase , but not or JNK , by either TCR-stimuli or IL-12 and [IL-18] is diminished in Gadd45b ( -/- ) CD8 ( + ) T cells , resulting in reduced production of IFN-gamma . Positive_regulation IL18 F3 7635444 317261 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL18 FAS 10514014 651524 Caspase-1 independent , ligand *mediated* [IL-18] secretion from macrophages causes acute liver injury in mice . Positive_regulation IL18 FAS 11464579 839439 [IL-18] *induces* expression , whereas FADD is a constitutively expressed gene in human fetal membranes . Positive_regulation IL18 FAS 23509366 2766917 However , the role of *mediated* production of proinflammatory cytokines such as [IL-18] and IL-1ß in bacterial infection is unclear . Positive_regulation IL18 IL1B 12022703 943288 The results obtained indicate that recombinant human [IL-18] ( rhIL-18 ) *induces* and , to a lesser extent , sIL-1RII production by human neutrophil isolated from peripheral blood . Positive_regulation IL18 IL1B 14617515 1200639 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL18 IL1B 16375968 1547128 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL18 IL1B 24453428 2884403 We found that Nlrp3 ( -/- ) mice have more severe liver injury with higher plasma alanine aminotransferase ( ALT ) levels , increased *activation* of [IL-18] , and reduced activation of . Positive_regulation IL18 IL1B 9449707 483951 [Interleukin-18] ( IFNgamma inducing factor ) *induces* IL-8 and via TNFalpha production from non-CD14+ human blood mononuclear cells . Positive_regulation IL18 IL1R2 8387521 218026 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL18 MAP2K6 17274000 1697242 Inhibitors of PI3 K , p38 MAPK , and *suppressed* [IL-18] plus IFN-gamma induced CXCL9 , CXCL10 , and CXCL11 production and NF-kappaB , STAT1 , and IRF-1 activities . Positive_regulation IL18 PGC 22117073 2535013 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL18 STAT4 11120802 758231 This is due to defective IL-18 signaling , which results from the lack of IL-12 induced , and *dependent* , expression of the [IL-18R] . Positive_regulation IL18 STAT4 7638186 317678 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL18 TF 18835036 2012811 *induces* [interleukin-18] expression in chronic myeloid leukemia cell line , K-562 . Positive_regulation IL18 TF 18835036 2012812 In conclusion , *regulates* [IL-18] expression and we suggest that it is involved in cytokine production . Positive_regulation IL18 TF 19535202 2162476 [Interleukin-18] *induces* expression in breast cancer cell line MCF-7 . Positive_regulation IL18 TLR7 12045249 950118 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL18 TLR7 17404311 1722001 Alum induced IL-1beta and [IL-18] production was not *due* to enhancement of signaling but rather reflected caspase-1 activation and in mouse dendritic cells occurred in a MyD88 independent fashion . Positive_regulation IL18 TLR7 18312842 1879368 Toxoplasma profilin is essential for host cell invasion and dependent *induction* of an [interleukin-12] response . Positive_regulation IL18 TLR7 20632067 2368001 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in mediated *activation* of caspase 1 and [interleukin-1ß] . Positive_regulation IL18 TLR7 22521509 2613539 signaling *triggers* the transcriptional activation of pro-interleukin-1ß ( pro-IL-1ß ) and [pro-IL-18] that are processed into their active forms by the inflammasome . Positive_regulation IL18 TLR7 23246311 2732063 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL18 TNF 10969796 728400 IL-10 decreased the production of IL-6 and the expression of IL-12 in the *presence* of or sCD40L , but it had no effect on IL-15 , [IL-18] , and TNF-alpha secretion . Positive_regulation IL18 TNF 11859116 914756 In contrast , IL-1alpha , IL-1beta , , IFN-gamma-inducible protein-10 , and Th2 cytokines such as IL-4 and IL-10 did not *induce* [IL-18BPa] . Positive_regulation IL18 TNF 12023376 943787 Because disease severity was increased in IFN-gamma ( -/- ) vs IL-18 neutralized mice , and since [IL-18] also *induces* production of , we tested for TNF-alpha in both groups . Positive_regulation IL18 TNF 12684057 1077873 Both and H ( 2 ) O ( 2 ) *induced* IL-18 mRNA and precursor protein in cardiomyocytes , and [IL-18] release into culture supernatants . Positive_regulation IL18 TNF 1463043 206756 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL18 TNF 15207779 1261683 Previously , we reported that production could be detected in human peripheral blood mononuclear cells ( PBMCs ) treated with relatively low concentration of LPS ( 1 ng/ml ) , but that same concentration of LPS could not *induce* [IL-18] production . Positive_regulation IL18 TNF 15894108 1407799 Tissue culture model of renal epithelial cells expressed IL-18 mRNA constitutively and released mature [IL-18] in *response* to and IFN-gamma . Positive_regulation IL18 TNF 15949134 1421202 [IL-18] is a pro-inflammatory cytokine of the IL-1 family and it *induces* IL-1 , , and IL-6 , all of which are endogenous pyrogens . Positive_regulation IL18 TNF 16464907 1567563 *induced* [IL-18] gene expression in muscle tissue , but not in adipose tissue , whereas IL-6 infusion had no effect on IL-18 gene expression in either tissue . Positive_regulation IL18 TNF 16502344 1496234 Both cell lines upregulated IL-18R mRNA and [IL-18R] membrane expression in *response* to and other proinflammatory cytokines . Positive_regulation IL18 TNF 17854477 1795890 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving *dependent* [interleukin-12] induction . Positive_regulation IL18 TNF 19285156 2127934 In CLE but not normal keratinocytes [IL-18] strongly *induces* release , which then results in apoptosis . Positive_regulation IL18 TNF 19879772 2203361 TGF-beta1 experience by cells leads to sustained long-term inactivation of mediated cell activation but not [IL-18] induced p38 *activation* suggesting transcriptional silencing of the T-BET and/or IFNG promoter independent of MAPK signalling . Positive_regulation IL18 TNF 19907017 2209844 *causes* release of cytosolic [interleukin-18] from human neutrophils . Positive_regulation IL18 TNF 19907017 2209846 In turn , stimulation disrupted the association of IL-18 with F-actin , *induced* a FRET+ interaction of [IL-18] with lipid rafts , and elicited IL-18 release . Positive_regulation IL18 TNF 19907017 2209847 We conclude that human PMNs contain [IL-18] associated with F-actin in the cytoplasm and stimulation *causes* dissociation of IL-18 from F-actin , association with lipid rafts , and extracellular release . Positive_regulation IL18 TNF 20131228 2219908 *induced* RA synovial fibroblast [IL-18BPa] and IL-18 in a time dependent manner ( P < 0.05 ) . Positive_regulation IL18 TNF 20131228 2219912 Evaluation of signaling pathways suggested that *induced* [IL-18] production through the ERK-1/2 , protein kinase Cdelta (PKCdelta) , and Src pathways , whereas IL-18BPa synthesis was mediated through the NFkappaB , PKC , Src , and JNK pathways . Positive_regulation IL18 TNF 20586818 2339857 TFCs were major cell types expressing IL-18 in the thyroid tissues of HT . [IL-18] was constitutively expressed in isolated human TFCs , and the expression was significantly *up-regulated* by IFN-? rather than or IL-1ß . Positive_regulation IL18 TNF 2113076 135545 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL18 TNF 21745554 2471913 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL18 TNF 22198666 2629424 [IL-18] *induces* IFN-? , IL-17 , and , which may play an important pathogenic role in AOSD . Positive_regulation IL18 TNF 2370931 138348 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL18 TNF 24687687 2942941 Importantly , NKT cells were found to act as regulators of NLRP3 inflammasome signaling , as NKT-cell derived was *required* for optimal IL-1ß and [IL-18] production by myeloid cells in response to a-galactosylceramide , by acting on the NLRP3 inflammasome priming step . Positive_regulation IL18 TNF 3011946 59757 interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL18 TNF 3486658 59956 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL18 TNF 3486658 60010 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL18 TNF 3486936 60099 ( cachectin ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL18 TNF 3500495 80708 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL18 TNF 3526909 62649 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL18 TNF 7506142 237745 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL18 TNF 7737374 305517 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL18 TNF 8132326 251523 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL18 TNF 8592105 341913 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL18 TNF 8592105 341968 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL18 TNF 8910536 395210 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL18 TNF 9893178 586786 [IL-18] *induces* gene expression and synthesis of , IL-1 , Fas ligand , and several chemokines . Positive_regulation IL18BP TNF 12684057 1077874 and H ( 2 ) O ( 2 ) *induced* delayed expression of [IL-18 BP] . Positive_regulation IL18BP TNF 20878981 2452789 IFN-? induced secretion of [IL-18BP] was *enhanced* by added , IFN-a and IFN-ß . Positive_regulation IL18BP TNF 21834067 2495729 To examine the role of interferon regulatory factor 1 (IRF-1) in *induced* [interleukin-18 binding protein] a ( IL-18BPa ) expression in rheumatoid arthritis synovial fibroblasts ( RASFs ) . Positive_regulation IL19 ABCG2 20846001 2375400 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL19 CCL17 22057112 2540319 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL19 DAPK1 24220855 2897428 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL19 EPHB2 12609986 1085295 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL19 EPHB2 18310510 1904111 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL19 F3 7635444 317264 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL19 IL1B 14617515 1200640 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL19 IL1B 16375968 1547129 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL19 IL1B 18246602 1865212 [IL-19] also promoted neutrophil chemotaxis , reduced neutrophil apoptosis , and *induced* the production of proinflammatory cytokines and chemokines ( ] , IL-6 , IL-8 , CCL5 , and CXCL9 ) in lung epithelial cells . Positive_regulation IL19 IL1B 20001767 2225093 *increased* [IL-19] levels in PBMCs , suggesting that elevated levels of IL-1 in RA joints may contribute to upregulated IL-19 expression . Positive_regulation IL19 IL1R2 8387521 218028 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL19 PGC 22117073 2535014 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL19 STAT4 7638186 317679 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL19 TLR7 12045249 950119 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL19 TLR7 18312842 1879382 Toxoplasma profilin is essential for host cell invasion and dependent *induction* of an [interleukin-12] response . Positive_regulation IL19 TLR7 20632067 2368003 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in mediated *activation* of caspase 1 and [interleukin-1ß] . Positive_regulation IL19 TLR7 22521509 2613549 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL19 TLR7 23246311 2732077 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL19 TNF 12370360 995883 [IL-19] *induces* production of IL-6 and and results in cell apoptosis through TNF-alpha . Positive_regulation IL19 TNF 1463043 206758 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL19 TNF 17854477 1795891 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving dependent [interleukin-12] *induction* . Positive_regulation IL19 TNF 2113076 135546 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL19 TNF 21745554 2471915 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL19 TNF 2370931 138349 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL19 TNF 3011946 59758 Tumor necrosis interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL19 TNF 3486658 59957 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL19 TNF 3486658 60011 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL19 TNF 3486936 60100 Tumor necrosis factor ( ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL19 TNF 3500495 80709 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL19 TNF 3526909 62650 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL19 TNF 7506142 237746 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL19 TNF 7737374 305518 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL19 TNF 8132326 251524 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL19 TNF 8592105 341914 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL19 TNF 8592105 341969 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL19 TNF 8910536 395211 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL1A ABCG2 22750628 2659714 In conclusion , [IL-1ß] and TNF-a *induced* and PXR expression and NF-?B activity in some breast cancer and normal cell lines . Positive_regulation IL1A ALOX5 8722494 373709 Leukotriene B4 ( 1-100 ng/mL-1 ) added to MK-886 ( 5 microM ) -treated cultures reversed the inhibitory effects of the latter on IL-1 , confirming the *role* of <5-lipoxygenase> products in the regulation of [IL-1] production . Positive_regulation IL1A ANGPT1 24563688 2919348 We observed that ( 10 ( -8 ) M ) , but not Ang2 , *increased* mRNA expression of prominent pro-inflammatory cytokine [IL-1ß] and its natural antagonist IL-1RA , by up to 32.6- and 10.0-fold respectively , compared to PBS-control . Positive_regulation IL1A ANGPT1 24563688 2919352 The effects of extended to the proteins , as Ang1 *increased* intracellular levels of precursor and mature [IL-1ß] , and extracellular levels of IL-1RA proteins , by up to 4.2- , 5.0- and 4.4-fold respectively , compared to PBS-control . Positive_regulation IL1A CAPN8 18498295 1928067 However , genotype also had no effect on inhibition of IL-1alpha release by pretreatment with calpain inhibitors , and inhibitors *reduced* [IL-1alpha] and tumor necrosis factor alpha mRNA levels . Positive_regulation IL1A CD14 15863460 1439682 Low concentrations ( ng/ml ) of Escherichia coli LPS , the prototypical TLR4 agonist , markedly stimulated extracellular regulated kinase 1/2 ( ERK1/2 ) activity , induced release of monocyte-chemoattractant protein-1 ( MCP-1 ) and interleukin (IL)-6 , and stimulated [IL-1alpha] expression in human aortic SMC , and exogenous *enhanced* these effects . Positive_regulation IL1A CD14 20946675 2337946 The activation of , TLR4 , and TLR2 by mmLDL *induces* [IL-1ß] , IL-6 , and IL-10 secretion in human monocytes and macrophages . Positive_regulation IL1A DAPK1 21041719 2376305 Tumor suppressor is *required* for full [IL-1ß] production . Positive_regulation IL1A DAPK1 21041719 2376308 Here we show that tumor suppressor deficiency *impaired* [IL-1ß] production in macrophages . Positive_regulation IL1A EGLN3 22948157 2697698 Here , we show that in NP cells , TNF-a and [IL-1ß] *induce* expression through NF-?B . Positive_regulation IL1A EPHB2 10648566 662084 [Interleukin 1alpha (IL-1alpha)] strongly *induced* activation as well as NF-kappaB activation . Positive_regulation IL1A EPHB2 11402003 824763 When cells were stimulated by SAC , inhibition of the p38 pathway did not affect cytokine production , whereas only [IL-1alpha] production was decreased in the *presence* of kinase inhibitor . Positive_regulation IL1A EPHB2 12009331 941001 [IL-1] rapidly *induced* the activation of extracellular-signal regulated kinase ( ) , protein 38 (p38) and c-Jun N-terminal kinase (JNK) MAPKs in the first-passage human femoral head OA chondrocytes . Positive_regulation IL1A EPHB2 12322783 991431 Previous studies using various stimuli have shown *dependent* [IL-1] induction . Positive_regulation IL1A EPHB2 12609986 1085306 Inhibitors of activation *prevent* dsRNA induced ERK phosphorylation and [IL-1] expression by macrophages . Positive_regulation IL1A EPHB2 12654926 1092228 Inhibition of in transgenic keratinocytes *reduced* basal [IL-1alpha] levels and the stimulation of IL-1alpha production by serum or phorbol ester , demonstrating that Erk could regulate IL-1alpha expression . Positive_regulation IL1A EPHB2 12654926 1092231 Inhibition of transactivation blocked basal and TPA or [IL-1alpha] *induced* activation , but not IkappaBalpha degradation , and abolished increased IL-1alpha production in transgenic cells . Positive_regulation IL1A EPHB2 20854249 2346741 In cultures of primary mouse brain endothelium and the rat brain endothelial GPNT cell line , interleukin-1ß ( [IL-1ß] *induced* a rapid ( within 5 minutes ) and transient activation of p38 and JNK ( but not ) MAP kinases . Positive_regulation IL1A EPHB2 21354239 2431664 Pharmacological studies revealed that the integrity of lipid raft and the activation of Src , Ras , Raf , , and NF-?B all *contributed* to JEV induced TNF-a and [IL-1ß] expression . Positive_regulation IL1A EPHB2 21571370 2441386 Surprisingly though , inhibition of the and JNK non-Smad pathways also completely *blocked* the induction of [IL-1ß] by BMP-6 in macrophages . Positive_regulation IL1A EPHB2 21600652 2449875 [IL-1ß] production was *suppressed* by inhibitors of lipid rafts , , JNK , and p38 kinases . Positive_regulation IL1A EPHB2 21719512 2483865 Focal adhesions and Ras are functionally and spatially integrated to mediate [IL-1] *activation* of . Positive_regulation IL1A EPHB2 22237943 2591935 We assessed production of NO , synthesis of [IL1ß] and *activation* of , JNK and NF-?B signaling pathways by Western blot , in primary rat glial cultures exposed to SR ligands ( fucoidan and Poly I ) , LPS + IFN? (LI) , and Aß . Positive_regulation IL1A EPHB2 24339030 2905324 In addition , ROS , MAPK , and NF-?B activities increased , while inhibitors of ROS , , and NF-?B *reduced* [IL-1ß] production . Positive_regulation IL1A F3 3502509 83798 [IL-1] *induces* synthesis of prostacyclin , platelet activating factor , and plasminogen activator inhibitor . Positive_regulation IL1A FAS 12946945 1143238 These data suggest that calpains play a dominant role in *induced* [IL-1alpha] release and MCP-1 upregulation and that caspase activation may function to amplify the effects of calpain activation . Positive_regulation IL1A FAS 23144495 2707413 However , the mechanisms by which *regulates* [IL-1ß] activation remain unresolved . Positive_regulation IL1A FAS 23509366 2766918 However , the role of *mediated* production of proinflammatory cytokines such as IL-18 and [IL-1ß] in bacterial infection is unclear . Positive_regulation IL1A FOXO1 19651810 2150055 selectively *promoted* [IL-1ß] production in cultured macrophages . Positive_regulation IL1A FOXO1 19651810 2150056 Mutations of the FoxO1 binding site within the IL-1ß promoter abolished *induction* of [IL-1ß] expression . Positive_regulation IL1A FUT4 21365246 2411512 The *activation* of FUT1 , FUT2 and by [IL-1ß] is through the NF-?B pathway and the down-regulation of FUT3 and FUT5 by IL-6 is through the gp130/STAT-3 pathway , since they are inhibited specifically by panepoxydone and AG490 , respectively . Positive_regulation IL1A GLP1R 24048027 2846352 induced suppression of food intake , and body weight is *mediated* by central [IL-1] and IL-6 . Positive_regulation IL1A HBEGF 22911722 2648574 These results suggest that contact with fibroblasts stimulates the migration and proliferation of keratinocytes during wound healing , and that plays a central role in this process and can be *up-regulated* by [IL-1a] and TGF-ß1 , which also regulate keratinocyte proliferation differently during the early and late stage . Positive_regulation IL1A IL1B 10209072 607366 [IL-1alpha] but not *induced* prostaglandin synthesis is inhibited by corticotropin releasing factor . Positive_regulation IL1A IL1B 10326728 612844 Recombinant human ( rh ) *stimulated* membrane [IL-1] activity , which was mainly attributed to IL-1 alpha . Positive_regulation IL1A IL1B 10381547 624238 In both young and old rats , *induced* a significant up-regulation of cerebellar IL-1Ra , [IL-1RI] , and TGF-beta1 mRNAs ; Positive_regulation IL1A IL1B 11091227 754812 This study demonstrated for the first time the presence of [IL-1] receptors on megakaryocytic cells and the *induction* of NF-E2 by . Positive_regulation IL1A IL1B 11526216 853141 Furthermore , a bacterial mutant that does not induce [IL-1 alpha] expression but *induces* normal levels of , TNF-alpha , and IFN-gamma , causes greatly reduced intestinal inflammation and is attenuated by LD ( 50 ) analysis in the C57BL/6 mouse model . Positive_regulation IL1A IL1B 11723165 884122 Using RT-PCR , we first showed that the expression of [IL-1RI] and IL-1RII , but not IL-1RacP , mRNAs are *up-regulated* by in a time dependent manner . Positive_regulation IL1A IL1B 1378763 192679 [IL-1 alpha] activity was *detected* only intracellularly and not in the supernatant , while was not produced at all . Positive_regulation IL1A IL1B 1533322 186460 A 10-fold molar excess of IL-1ra over IL-1 beta reduced *induced* [IL-1 alpha] by 95 % ( P = .01 ) and IL-1 alpha induced IL-1 beta by 73 % ( P less than .01 ) . Positive_regulation IL1A IL1B 1533322 186462 A similar reduction in *induced* [IL-1 alpha] was observed when IL-1 beta was removed from the cultures after 8 hours of stimulation ( P less than .05 ) , suggesting a prolonged presence of IL-1 or restimulation of IL-1 receptors on monocytes is required for the induction of cytokines . Positive_regulation IL1A IL1B 1533322 186463 In elutriated monocytes , a 10-fold molar excess of IL-1ra reduced *induced* [IL-1 alpha] by 82 % ( P less than .05 ) , TNF alpha by 64 % ( P = .05 ) , and IL-6 by 47 % ( P less than .05 ) . Positive_regulation IL1A IL1B 15684062 1370853 We show that incubating murine hepatocytes with IL-6 , [IL-1alpha] , and strongly *stimulates* hepcidin transcription . Positive_regulation IL1A IL1B 15774504 1397280 CXCL8 and CXCL1 production by human astrocytes at both the RNA and protein levels could be *induced* by [interleukin (IL)-1beta] , while CXCL10 was induced by both and interferon-gamma . Positive_regulation IL1A IL1B 16912431 1602078 The results show that LPS and IL-1alpha increase intracellular and Diacerein inhibited LPS induced and [IL-1alpha] *induced* IL-1beta production by articular chondrocytes . Positive_regulation IL1A IL1B 1715791 165017 In this study , we investigated the *role* of in the malignant evolution of chronic myelogenous leukemia ( CML ) and the functional activity of [IL-1] inhibitors . Positive_regulation IL1A IL1B 18419766 1944473 Here we show that stimulation of astrocytes with , lipopolysaccharide or ethanol ( 10 and 50 mM ) , *triggers* the translocation of [IL-1RI] and/or TLR4 into lipid rafts caveolae enriched fractions , promoting the recruitment of signalling molecules ( phospho-IL-1R associated kinase and phospho-extracellular regulated-kinase ) into these microdomains . Positive_regulation IL1A IL1B 18609176 1972346 Cultures of human primary hepatocytes showed that [IL-1sRII] is *induced* by , but not IL-6 . Positive_regulation IL1A IL1B 1918980 168438 We have previously demonstrated that [Il-1] and TNF could rapidly , but transiently , *induce* gene expression of in human polymorphonuclear leukocytes ( PMN ) at both the protein and mRNA level . Positive_regulation IL1A IL1B 1918980 168442 Using nuclear run-on transcription analysis , we found that within 1 h Il-1 , TNF , and TNF plus [Il-1] *induced* the transcription of the gene by 33- , 61- , and 99-fold , respectively . Positive_regulation IL1A IL1B 1954872 172415 *induces* [interleukin-1 alpha] messenger ribonucleic acid expression in primary cultures of Leydig cells . Positive_regulation IL1A IL1B 1954872 172417 In the present study we found that human recombinant ( 1-100 ng/ml ) *caused* dose dependent increases in [IL-1 alpha] mRNA expression in Leydig cells . Positive_regulation IL1A IL1B 19592492 2130634 Stable lines of IL-18Ralpha depleted human A549 cells were generated using shRNA , resulting in an increase of *induced* [IL-1alpha] , IL-6 , and IL-8 compared to scrambled small hairpin RNA . Positive_regulation IL1A IL1B 20034811 2205175 High glucose and also *enhance* the translocation of [IL-1RI] to the nucleus . Positive_regulation IL1A IL1B 2032514 159576 Using the thymocyte proliferation assay , sera from the same patients contained significantly increased inhibitory activity against [interleukin-1 alpha] ( P = 0.025 ) and induced cell *activation* ( P = 0.00005 ) as compared with controls . Positive_regulation IL1A IL1B 2036955 159759 [IL-1 alpha] and ( 0.04-25 ng/ml ) significantly *increased* IL-6 release 3- to 4-fold in a concentration related manner during 6-h incubations ; Positive_regulation IL1A IL1B 2047762 160333 LPS *induced* production of high levels of both [IL-1 alpha] and IL-1 beta protein ( quantitated with type-specific ELISA assays ) , while after PMA stimulation only protein could be detected . Positive_regulation IL1A IL1B 2062178 162253 Recombinant human and TNF-alpha *stimulate* production of [IL-1 alpha] and IL-1 beta by vascular smooth muscle cells and IL-1 alpha by vascular endothelial cells . Positive_regulation IL1A IL1B 21219853 2392109 In the presence of BAY , [IL-1ß] *induced* mRNA levels were decreased by 6-fold . Positive_regulation IL1A IL1B 22572995 2638062 Collectively , the results indicated that *regulates* expression of IL1R1 and [IL1RAP] and stimulates expression of PTGS1 and PTGS2 that are considered to be the most rate limiting enzymes for endometrial synthesis of PGs during the peri-implantation period of pregnancy in pigs . Positive_regulation IL1A IL1B 2646146 108710 BSF-2/IL-6 , GM-CSF and mRNAs were *induced* by recombinant [IL-1] in human astrocytoma cell line U373MG . Positive_regulation IL1A IL1B 3131429 92709 IFN-gamma inhibited *induced* [IL-1 alpha] as well as IL-1 alpha induced IL-1 beta production ; Positive_regulation IL1A IL1B 3259964 92898 [IL-1 alpha] was not *detected* in the total RNA extracted from freshly excised kidney , whereas transcripts were detected in both the renal cortex of MRL-lpr as well as MRL-++ animals . Positive_regulation IL1A IL1B 3497982 77894 The results of these neutralizations showed that recombinant human [IL-1-alpha] *induces* the synthesis of in human MNC in vitro . Positive_regulation IL1A IL1B 3497982 77896 These results demonstrate that [IL-1-alpha] *induces* biologically active and immunoreactive from MNC in vitro and that the same concentrations of IL-1-alpha induce gene expression for both forms of IL-1 . Positive_regulation IL1A IL1B 7485466 326839 *induced* production of both IL-1Ra and [IL-1 alpha] at each time point and concentration tested . Positive_regulation IL1A IL1B 7686496 222173 Intracellular [IL-1 alpha] and IL-1 beta levels were markedly *enhanced* by and TNF alpha . Positive_regulation IL1A IL1B 7687636 222485 *induced* [IL-1 alpha] and TNF-alpha were reduced by 84 % ( p = 0.01 ) and 68 % ( p < 0.001 ) , respectively . Positive_regulation IL1A IL1B 7720088 301426 While neither IL-1 alpha or was detected in culture supernatants from macrophages treated with either LPS or MTP ( alone or in combination with IFN ) , [IL-1 alpha] was *detected* in cell lysates of macrophages treated with these upregulators . Positive_regulation IL1A IL1B 7853198 294794 *Stimulation* of cell associated [IL-1 alpha] production by or lipopolysaccharide was also inhibited by pretreatment with the PKC activator TPA , aplysiatoxin or teleocidin . Positive_regulation IL1A IL1B 8243265 236513 We conclude that 1 ) [IL-1] receptors are involved in the ACTH and IL-6 *responses* to rat ; Positive_regulation IL1A IL1B 8243804 236688 also *induced* [IL-1 alpha] mRNA accumulation ; Positive_regulation IL1A IL1B 8341137 226203 The metabolite , p-HPPH ( 1.2-2.4 micrograms/ml ) , did not induce PGE2 formation itself but potentiated [IL-1 alpha] and *induced* PGE2 formation in the gingival fibroblasts in a manner dependent on the concentration of both IL-1 and p-HPPH . Positive_regulation IL1A IL1B 8580368 337503 Captopril dose-dependently suppressed the *induced* synthesis of TNF by 74 % ( P < 0.01 ) and the IL-1 beta induced synthesis of [IL-1 alpha] by 60 % ( P < 0.01 ) . Positive_regulation IL1A IL1B 8591999 350632 Several lines of evidence suggest that the biologic effects of are *mediated* by activation of type I [IL-1] receptors ( IL-1RI ) and induction of GM-CSF production . Positive_regulation IL1A IL1B 8638287 342968 IL-2 , IL-6 , IL-8 , TNF-alpha , TNF-beta and IFN-gamma , but not [IL-1 alpha] , were *detected* in the monkey using human reagents . Positive_regulation IL1A IL1B 8780161 380047 After 24 hours , contact allergens not only increased the expression of but also *induced* the expression of [IL-1 alpha] , TNF-alpha , GM-CSF , and IL-6 proteins mainly by suprabasal keratinocytes . Positive_regulation IL1A IL1B 8941673 399296 By semiquantitative reverse transcriptase PCR , we demonstrated that IL-1alpha and *stimulated* the expression of KGF , HGF , IL-1alpha , IL-1beta , [IL-1RI] , and IL-8 in fibroblasts regardless of their physiologic condition , whereas that of TGF-beta remained unaffected . Positive_regulation IL1A IL1B 9384305 466258 [IL-1RI] mRNA levels were *up-regulated* in PBMCs by recombinant bovine ( rBoIL-1beta ) , recombinant bovine granulocyte-macrophage colony stimulating factor ( rBoGM-CSF ) , rBoIL-4 , recombinant bovine gamma interferon ( rBoIFN-gamma ) , and dexamethasone . Positive_regulation IL1A IL1B 9389745 467401 Northern blot analyses demonstrate that bFGF strongly potentiates the formation of *induced* [IL-1] type I receptor mRNA levels , whereas PDGF-BB has no effect . Positive_regulation IL1A IL1B 9530240 496739 Brain type I but not type II [IL-1] receptors *mediate* the effects of on behavior in mice . Positive_regulation IL1A IL1B 9659156 517167 Stimulation of HIMEC and HUVEC with recombinant human ( rh ) or rhTNF-alpha *induced* cell associated bioactive [IL-1 alpha] but not IL-1 beta , as well as enhanced secretion of both IL-6 and IL-8 . Positive_regulation IL1A IL1B 9663558 518381 The hypothesis states that following infection and the release of cytokines such as IL-1beta into local tissue or microvasculature , *stimulates* [IL-1] receptors on vagal afferent terminals , or more likely on cells of vagal paraganglia . Positive_regulation IL1A IL1B 9719938 528495 This study suggested that the patients with bladder cancer renal cell carcinoma and prostatic cancer did not spontaneously produce [IL-1 alpha] or IL-1 beta , but that the ability to produce IL-1 alpha and in response to LPS stimulation was not significantly *impaired* . Positive_regulation IL1A IL1R2 19026558 2017057 Ectopic expression of specifically blocked exogenous IL-1beta signaling but *increased* expression of the precursor form of [IL-1alpha] ( pIL-1alpha ) and its downstream targets , including interleukin 6 (IL-6) , interleukin 8 (IL-8) , and type I collagen alpha1 ( COL1A1 ) . Positive_regulation IL1A IL1R2 22811570 2676701 Overexpression of using cell transfection *inhibited* [IL1] and hCG/IL1B mediated MCP1 secretion . Positive_regulation IL1A IL1R2 23999049 2851285 Importantly , the stimulatory effect of rgcIL-1ß on its own mRNA expression was blocked by rgcIL-1R2 in a dose dependent manner in grass carp HKLs , providing the evidence for a functional *role* of in [IL-1ß] signaling in teleost . Positive_regulation IL1A MAP2K6 10606930 655858 The results showed that TNF alpha , [IL-1 alpha] and PAF *induced* serine phosphorylation of MKK3 and , and p38 MAP kinase activation in BECs . Positive_regulation IL1A MMP7 9162049 431897 expression in LNCaP cells was also *induced* by recombinant [interleukin (IL)-1] ( 50 pM ) , but not by equimolar concentrations of recombinant tumor necrosis factor-alpha or IL-6 . Positive_regulation IL1A NEDD9 19754427 2153300 In these cells [IL-1] does not activate IKKbeta or *induce* the phosphorylation of , and nor does the IKKbeta inhibitor PS1145 prevent the IL-1 induced activation of transfected Tpl2 . Positive_regulation IL1A PLAT 23707980 2819588 is also *sufficient* to induce [IL-1ß] and pERK expression in astrocyte cultures . Positive_regulation IL1A PLAU 16504015 1529142 Based on these findings , we conclude that [IL-1alpha] can *induce* selective upregulation of alpha6beta1-integrin and in pancreatic cancer cells and these changes may modulate the aggressive functions of pancreatic cancer . Positive_regulation IL1A PLAU 1905804 161647 Transcription of the human ( uPA ) gene in HeLa cells is *induced* by phorbol myristate acetate ( PMA ) , [interleukin-1 (IL-1)] and tumor necrosis factor alpha (TNF alpha) . Positive_regulation IL1A PLAU 8772229 344232 These results suggest that both [IL-1 alpha] and IL-1 beta cause a rapid activation of uPA gene transcription in which de novo protein synthesis is not required and that LPS *induces* gene expression independently of the IL-1 pathway . Positive_regulation IL1A PPBP 24335961 2905205 promoted cell proliferation in vivo and in vitro , in which expression of CXCL7 was *induced* by the central proinflammatory cytokine [interleukin (IL)-1ß] . Positive_regulation IL1A SELL 1680022 166506 The [IL-1] present in melanoma conditioned medium *induced* the expression of vascular cell adhesion molecule 1 , , and ICAM-1 on human umbilical vein endothelial cells ( ECs ) in culture and increased the rate at which melanoma cells and ECs adhered to each other . Positive_regulation IL1A SPHK1 19074142 2030486 *Activation* of expression by [IL-1] occurs on the level of transcription and is mediated via a novel AP-1 element located within the first intron of the sphk1 gene . Positive_regulation IL1A STK39 8027056 263434 Genistein , at an unsaturating dose , plus a inhibitor , H7 , completely *blocked* the autocrine induction of [IL-1 alpha] suggesting that expression of this gene is regulated by tyrosine kinase ( s ) in combination or independently with serine/threonine kinase ( s ) . Positive_regulation IL1A TCN1 23973554 2873379 *increased* the expression of TLR4 and the EphB1 receptor , the activation of astrocytes and microglial cells , and increased levels of [interleukin-1ß (IL-1ß)] and tumor necrosis factor-a (TNF-a) . Positive_regulation IL1A TCN1 23973554 2873383 The induced *activation* of astrocytes and microglial cells , as well as the increased levels of [IL-1ß] and TNF-a , were inhibited by intrathecal administration of TLR4 targeting siRNA2 and the EphB receptor antagonist EphB2-Fc , respectively . Positive_regulation IL1A TGM2 24265865 2869848 All together , OPG and is *induced* by [IL-1ß] or TPA in MG-63 cells and Tgase-2 is involved in OPG expression in MG-63 cells . Positive_regulation IL1A TLR7 11909531 923638 MyD88 is an adaptor protein that is involved in [interleukin-1 receptor (IL-1R)-] and induced *activation* of NF-kappaB . Positive_regulation IL1A TLR7 15241416 1270541 Transcription of IkappaBzeta is rapidly induced by *stimulation* with ligands and [interleukin-1 (IL-1)] . Positive_regulation IL1A TLR7 16538507 1574474 binding *results* in cell signal transduction and subsequent production of various proinflammatory cytokines such as [IL-1] and TNF-alpha . Positive_regulation IL1A TLR7 17919942 1819529 MDP enhanced obligate bacterial agonist *induction* of IL-23 and [IL-1] , which promoted IL-17 expression in T cells . Positive_regulation IL1A TLR7 18806225 1969758 *induced* TNF and [IL-1] production are normal in macrophages derived from spin mice . Positive_regulation IL1A TLR7 19819943 2164551 We conclude that FFA and stimulation induce proinflammatory factors in islets and that [IL-1RI] engagement *results* in signal amplification . Positive_regulation IL1A TLR7 20632067 2368055 Specific inhibition of the XOD activity attenuates mediated *activation* of caspase 1 and [IL-1ß] release . Positive_regulation IL1A TLR7 21628463 2459304 Human myeloid cells activate the NLRP3 inflammasome and secrete [interleukin (IL)-1ß] in *response* to various ligands , but the rate of secretion is much higher in primary human monocytes than in cultured macrophages or THP-1 cells . Positive_regulation IL1A TLR7 21957307 2502644 By using small interfering RNA screening , we further demonstrated that , among the RIG-I-like receptors (RLRs) and Toll-like receptors ( TLRs ) , only TLR2 , TLR6 , , and TLR9 *contribute* to the NF-?B dependent secretion of TNF and the inflammasome dependent secretion of [IL-1ß] in response to vMyxM013-KO virus infection . Positive_regulation IL1A TLR7 21968712 2617047 In this report , we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages , leading to incapability for the production of inflammatory cytokines like tumor necrosis factor (TNF)-a and [interleukin (IL)-1ß] in *response* to stimulation . Positive_regulation IL1A TLR7 22006336 2503280 Production of proinflammatory ( pro ) [-IL-1a] and pro-IL-1ß is *induced* by mediated NF-?B activation . Positive_regulation IL1A TLR7 22206014 2519064 R-848 activation of dependent signaling in cDCs *led* to a rapid upregulation of [pro-IL-1a] and pro-IL-1ß production compared to poly I:C activation of MyD88 independent signaling pathways . Positive_regulation IL1A TLR7 22345668 2572048 Knockdown of hnRNP U expression greatly attenuated TLR induced expression of TNF-a , IL-6 , and IL-1ß , but not IL-12 , whereas hnRNP U overexpression greatly increased *induced* expression of TNF-a , IL-6 , and [IL-1ß] . Positive_regulation IL1A TLR7 22649103 2620324 First , costimulation strongly *increased* transcription of [pro-IL-1ß] and IL-23p19 . Positive_regulation IL1A TLR7 22751696 2670311 To do so , we analyzed *induced* [interleukin (IL)-1ß] and IL-6 responses in freshly isolated peripheral blood mononuclear cells ( PBMNCs ) from seropositive compared with seronegative subjects . Positive_regulation IL1A TLR7 22751696 2670373 The dysregulated *induced* [IL-1ß] and IL-6 pathways were more readily detectable in children aged < 11 years and from 11 to < 21 years , respectively , and did not involve altered HbA ( 1c ) or the presence of one or more autoantibodies . Positive_regulation IL1A TLR7 23080298 2745182 KCs lacking Tpl2 display defects with *induction* of cytokines [interleukin (IL)-1ß] , IL-10 , and IL-23 . Positive_regulation IL1A TLR7 23225887 2718539 The first signal is provided by stimulation and *triggers* the synthesis of the [IL-1ß] precursor and Nlrp3 . Positive_regulation IL1A TLR7 23225887 2718549 In this article , we show that unlike macrophages , murine bone marrow derived and splenic dendritic cells (DCs) can secrete substantial amounts of mature [IL-1ß] upon *stimulation* with ligands in the absence of ATP stimulation . Positive_regulation IL1A TLR7 23225887 2718559 Furthermore , they challenge the idea that the ATP-P2X7 axis is critical for *induced* [IL-1ß] production via the Nlrp3 inflammasome in vivo . Positive_regulation IL1A TLR7 23878142 2865958 [IL-1ß] production by these cells *requires* and adenosine triphosphate ( ATP ) -mediated P2X purinoceptor 7 (P2X7) signals , which together activate the inflammasome . Positive_regulation IL1A TLR7 24126516 2889243 [IL-1ß] synthesis , maturation , and secretion are tightly *regulated* by signaling and inflammasome activation . Positive_regulation IL1A TLR7 24205068 2864725 We compared *induced* production of [pro-interleukin (IL)-1ß] , IL-6 , and tumor necrosis factor (TNF)-a between 2-month-old infants and adults . Positive_regulation IL1A TLR7 24205068 2864740 *induced* production of [pro-IL-1ß] and IL-6 in monocytes was lower in 2-month-old infants compared to adults . Positive_regulation IL1A TLR7 24205068 2864751 Lower *induced* production of [pro-IL-1ß] and IL-6 in innate immune cells during early infancy likely contributes to suboptimal vaccine responses and infectious diseases susceptibility . Positive_regulation IL1A TLR7 24439266 2901529 MyD88 relayed signals of *induced* [IL-1] , which became dispensable for Th1 cell responses in the absence of T regulatory ( Treg ) cells . Positive_regulation IL1A TLR7 24527714 2948932 PATIENTS were monitored for adverse effects of AAT therapy , C-peptide responses to a mixed-meal tolerance test , and *induced* cellular [IL-1ß] in monocytes and myeloid dendritic cells ( mDCs ) . Positive_regulation IL1A TLR7 24771848 2937048 In this article , we show that single engagement *induces* [IL-1ß] and , with a little delay , IL-1Ra . Positive_regulation IL1A TNF 10226804 610458 We conclude that [IL-1 alpha] and *increase* circulating levels of IGFBP-1 , reflecting direct effects on hepatic IGFBP-1 mRNA abundance . Positive_regulation IL1A TNF 10362047 619824 Monocyte chemotactic factors released from type II pneumocyte-like cells in *response* to and [IL-1alpha] . Positive_regulation IL1A TNF 10469279 641080 In addition , IL-17 increased *induced* [IL-1alpha] , IL-1beta , and IL-6 mRNA expression in fetal mouse metatarsals and IL-1alpha and IL-6 mRNA expression in MC3T3-E1 cells . Positive_regulation IL1A TNF 10498310 647568 These results suggest that the inhibitory effects of on cutaneous tissue repair are *mediated* in part by [IL-1] . Positive_regulation IL1A TNF 10643716 660982 In response to stimulation , messenger RNA ( mRNA ) levels for the IL-1 receptor I (IL-1RI) , [IL-1RII] , TNF receptor II (TNFR II) , and IL-6 receptor as well as the level of proinflammatory cytokines , such as IL-1alpha , IL-1beta , lymphotoxin beta , TNFalpha , and IL-6 , also *increased* . Positive_regulation IL1A TNF 10669637 665836 [IL-1alpha] induced expression and secretion of TNF-alpha protein , but LPS did not *induce* production of protein . Positive_regulation IL1A TNF 10768935 685065 IL-8 , [IL-1alpha] , IL-1beta , MCP-1 , GM-CSF , and mRNA expression *increased* within 1 h postinfection , reached a maximum after 3 to 4 h , and then declined to preinfection levels within 3 h . IL-8 , MCP-1 , and GM-CSF were secreted by HeLa cells , whereas IL-1alpha and IL-1beta were not secreted and thus were found exclusively intracellularly . Positive_regulation IL1A TNF 10918504 717002 Therefore , we examined the effect of NFkappaB decoy ODN transfection on *induced* endogenous [interleukin (IL)-1alpha] , IL-1beta , IL-6 , ICAM-1 and VCAM-1 gene expression as assessed by RT-PCR and Northern blotting . Positive_regulation IL1A TNF 11023661 738332 Although both IL-1 and activate NF-kappaB in these cells , only [IL-1] *induces* collagenase-1 transcription . Positive_regulation IL1A TNF 11027208 738602 The 5 ' NF-kB high-affinity binding site and AP-1 element contribute most to the enhancement of gene transcription in *response* to and [IL-1] . Positive_regulation IL1A TNF 11238627 790807 Likewise , SB203580 partially prevented the up-regulation of [IL-1alpha] , IL-1beta , IL-lRa , and TNF-alpha mRNA upon *stimulation* with LPS and , as well as the release of bioactive TNF-alpha induced by LPS . Positive_regulation IL1A TNF 11526216 853139 Furthermore , a bacterial mutant that does not induce [IL-1 alpha] expression but *induces* normal levels of IL-1 beta , , and IFN-gamma , causes greatly reduced intestinal inflammation and is attenuated by LD ( 50 ) analysis in the C57BL/6 mouse model . Positive_regulation IL1A TNF 11562770 862899 [IL-1alpha] *induced* the production of IL-6 , GM-CSF and from immortalized chondrocytes . Positive_regulation IL1A TNF 11743653 897868 iii ) In transformed clones of BALB/3T3 cells induced by TNF-alpha alone , [IL-1alpha] gene expression was *induced* after transformation by had occurred , which did not occur in parental cells . Positive_regulation IL1A TNF 11856640 914385 In addition , *induces* [IL-1] release by synovial fibroblasts and macrophages , and IL-1 , together with RANKL , is a major survival and activation signal for nascent osteoclasts . Positive_regulation IL1A TNF 12228766 988127 Thus captopril reduced *induced* IL-1beta and [IL-1betamRNA] synthesis in monocytes , in vitro , probably through interference with NF-kappaB activation of the IL-1beta gene . Positive_regulation IL1A TNF 12236623 989120 [IL-1] also augments osteoclast activation , and *induces* differentiation of early osteoclast precursors . Positive_regulation IL1A TNF 12356823 994047 The current study was undertaken to examine in immortalized human corneal epithelial cells whether NaOCl alters *induced* increases in expression of [IL-1alpha] gene and protein . Positive_regulation IL1A TNF 12370796 1034769 [IL-1] increased by 140 % in osteoclasts by day 3 and *increased* in osteoclasts by 120 % and 500 % in megakaryocytes on day 12 . Positive_regulation IL1A TNF 12402173 1009434 In addition , , but not [interleukin-1 (IL-1)] or lipopolysaccharide (LPS) , stimulation *resulted* in IkappaBalpha phosphorylation and degradation in two neuronal cell lines . Positive_regulation IL1A TNF 12709026 1083028 The expression of TLR2 protein by hepatocytes was also remarkably *up-regulated* by [IL-1alpha] and , to a lesser extent , by as well , but not by LPS or BLP . Positive_regulation IL1A TNF 1279199 202970 As can *increase* the production of [IL-1] and IL-6 and these inflammatory cytokines all enhance HIV-1 gene expression and affect the immune , vascular , and central nervous systems , the activation of TNF by Tat may be part of a complex pathway in which HIV-1 uses viral products and host factors to increase its own expression and infectivity and to induce disease . Positive_regulation IL1A TNF 1386144 193205 Its in vivo effect on C3 secretion might be secondary to the *induced* release of [IL-1] and/or IL-6 . Positive_regulation IL1A TNF 1479760 208182 Additional [IL-1 alpha] to the culture medium *induced* 3-4 times higher concentration of IL-6 in the culture supernatant compared with that of non stimulating cells , while exogenous did not stimulate IL-6 production . Positive_regulation IL1A TNF 15036245 1223858 We compared the production of [IL-1alpha] , IL-1beta , and of IL-1Ra isoforms by cultured human dermal ( HDF ) and synovial fibroblasts ( HSF ) in *response* to IL-1alpha , , or direct T cell membrane contact . Positive_regulation IL1A TNF 15162534 1253059 Time course studies revealed an increased production of TNF-alpha preceding the IL-1 production , suggesting that increased levels could be *involved* in the increase of [IL-1] production . Positive_regulation IL1A TNF 15230810 1269177 Adhesion molecules are upregulated by , e.g . [IL-1] , IL-4 , and IFN-gamma and the same cytokines may also *increase* the affinity of adhesion molecules both on eosinophils and endothelial cells . Positive_regulation IL1A TNF 15379215 1298203 Time course studies revealed an increased production of TNF-a preceding the IL-1 production , suggesting that increased levels could be *involved* in the increased [IL-1] production . Positive_regulation IL1A TNF 15668736 1369641 Reflecting sequential signaling of the cytokines TNF and IL-1 , *induces* stromal cell expression of [IL-1] and IL-1RI . Positive_regulation IL1A TNF 15672633 1350773 [IL-1alpha] and IL-1beta mRNA expression increased significantly ( p < 0.05 vs. sham-injury ) after severe TBI and IL-6 and mRNA expression *increased* significant ( p < 0.05 vs. sham-injury ) after both moderate and severe TBI . Positive_regulation IL1A TNF 1586593 187730 Analysis of peritoneal fluid and tumour xenografts showed that *induced* murine [IL-1] in the tumour bearing mice . Positive_regulation IL1A TNF 1639487 194648 *Induction* of tumor necrosis factor (TNF) and [interleukin-1 (IL-1)] by Pseudomonas aeruginosa and exotoxin A-induced suppression of lymphoproliferation and , lymphotoxin , gamma interferon , and IL-1 production in human leukocytes . Positive_regulation IL1A TNF 16888805 1672717 In hepatocytes or human hepatoma cells is expressed at extremely low levels but TNFalpha biosynthesis can be *induced* by [interleukin (IL)-1beta] or 12-O-tetradecanoylphorbol-13-acetate ( TPA ) . Positive_regulation IL1A TNF 1696166 137208 Both and LT mRNA were minimally *induced* by [IL-1 alpha] , IL-3 , interferon (IFN)-alpha , or IFN-gamma . Positive_regulation IL1A TNF 17100775 1644815 LPS , [interleukin (IL)-1] , IL-6 and *increased* and IL-10 reduced CRP expression in PBMC . Positive_regulation IL1A TNF 17525194 1746107 significantly *increased* [IL-1] RI levels . Positive_regulation IL1A TNF 17541168 1746933 We found that a potent androgen , 5alpha-dihydrotestosterone ( DHT ) inhibits [IL-1alpha] mRNA expression *induced* by and the DHT effect was inhibited by an androgen receptor antagonist , hydroxyflutamide ( OHF ) . Positive_regulation IL1A TNF 17541168 1746936 These results suggest that DHT inhibits the *induced* [IL-1alpha] mRNA expression by inhibiting NF-kappaB activation , and contributes to the gender differences of the disease . Positive_regulation IL1A TNF 17612514 1786756 Mechanism of *induced* [IL-1alpha] , IL-1beta and IL-6 expression in human cardiac fibroblasts : effects of statins and thiazolidinediones . Positive_regulation IL1A TNF 17612514 1786759 ( 0.1-10 ng/ml ) *stimulated* IL-6 , [IL-1alpha] and IL-1beta mRNA expression in cardiac fibroblasts in a concentration dependent manner . Positive_regulation IL1A TNF 17612514 1786762 In contrast , *induced* [IL-1alpha] expression required both TNFRI and TNFRII subtypes and p38 MAPK and PI3K/Akt pathways , but was negatively regulated by the NF-kappaB pathway . Positive_regulation IL1A TNF 17612514 1786763 Neither statins ( simvastatin , fluvastatin ) nor TZDs ( ciglitazone , rosiglitazone , troglitazone ) had inhibitory effects on *induced* IL-6 secretion or [IL-1alpha/beta] mRNA expression ; Positive_regulation IL1A TNF 17612514 1786765 Our data provide important insights into the regulation of pro-inflammatory cytokine expression in human cardiac fibroblasts and suggest that the myocardial anti-inflammatory effects of statins and TZDs are not due to inhibition of *induced* [IL-1] or IL-6 expression by cardiac fibroblasts . Positive_regulation IL1A TNF 1774433 175458 These results suggest that plays a major role in the pathogenesis of galactosamine/LPS hepatitis in mice and that [IL-1 alpha] *acts* synergistically with TNF in this hepatitis model . Positive_regulation IL1A TNF 1779975 175870 Secretion of by these cells is *induced* by exogenous TNF , but not by [IL-1] . Positive_regulation IL1A TNF 1796655 176328 It will focus on [interleukin-1 (IL-1)] , IL-1 *inhibitors* , , TNF inhibitors , Interleukin-6 (IL-6) , colony stimulating factors (CSF's) , Interferon-gamma (IFN-gamma) , growth factors , eicosanoids and prostaglandins , all of which are important in the effector phase of tissue destruction . Positive_regulation IL1A TNF 17967442 1826505 Peripheral TNFalpha , but not peripheral [IL-1] , *requires* endogenous IL-1 or induction in the brain for the febrile response . Positive_regulation IL1A TNF 18250170 1890710 *induces* [IL-1] expression and activates c-Fos , a transcription factor required in OCPs for osteoclast formation . Positive_regulation IL1A TNF 1906383 161716 GM-CSF , IL-2 and directly *induced* the production of cell associated IL-1 but little or no [IL-1] or TNF-alpha secretion . Positive_regulation IL1A TNF 1916153 168242 These results strongly suggest that [IL-1] has a inhibitory effect on hepatocytes in terms of DNA synthesis and that indirectly *induces* hepatocellular damage through the serine proteases which are possibly activated by the cytokine in vivo . Positive_regulation IL1A TNF 19196726 2182385 To determine whether directly triggers bone loss or *requires* [IL1] , human TNFalpha mice ( hTNFtg ) were crossed with mice lacking IL1alpha and IL1beta ( IL1 ( -/- ) hTNFtg ) . Positive_regulation IL1A TNF 1976521 141720 Although constitutive production was low , *stimulated* 5-20-fold increases in [IL 1] production in Thy-1- fibroblasts . Positive_regulation IL1A TNF 19827118 2271961 LMP1 mediated [IL-1alpha] and IL-1beta production could be *enhanced* by , determined by enzyme linked immunosorbent assay ( ELISA ) . Positive_regulation IL1A TNF 19924133 2217242 Furthermore , IL-27 alone greatly induced in vitro CXCL9 , CXCL10 , and CXCL11 production and tyrosine phosphorylation of signal transducer and activator of transcription 1 in normal human keratinocytes , while it suppressed the *induced* production of [IL-1alpha] and CCL20 . Positive_regulation IL1A TNF 20220144 2249414 We demonstrated previously that the gene encoding NGAL ( LCN2 ) is strongly *up-regulated* by [interleukin (IL)-1beta] in an NF-kappaB dependent manner but not by , another potent activator of NF-kappaB . Positive_regulation IL1A TNF 2062178 162252 Recombinant human IL-1 beta and *stimulate* production of [IL-1 alpha] and IL-1 beta by vascular smooth muscle cells and IL-1 alpha by vascular endothelial cells . Positive_regulation IL1A TNF 2069802 162593 E. coli , GBS and *had* no significant effect on the production of [IL-1] . Positive_regulation IL1A TNF 20704555 2357000 Moreover RHAs secrete IL-1ß and , only after the Aß1-42 treatment , *promotes* RCEC release of [IL-1ß] , IL-6 and TNF-a . Positive_regulation IL1A TNF 20943792 2347874 Quercetin , and to a lesser extent trans-RSV , attenuated the *induced* expression of inflammatory genes such as interleukin (IL)-6 , [IL-1ß] , IL-8 , and monocyte chemoattractant protein-1 ( MCP-1 ) and the secretion of IL-6 , IL-8 , and MCP-1 . Positive_regulation IL1A TNF 2115419 137419 preferentially *augmented* the production of cell associated [IL-1] in LPS stimulated cultures . Positive_regulation IL1A TNF 2115419 137421 induced a significant amount of IL-1 ( mainly cell associated ) directly but could also *induce* [IL-1] secretion when combined with IL-2 or IFN-gamma , or when in the presence of serum . Positive_regulation IL1A TNF 21251215 2509659 Nox2 and Nox4 siRNA were used to determine whether or not Nox2 and Nox4 mediated *induced* ROS and upregulation of [IL-1ß] and IL-6 in adult human cardiomyocytes . Positive_regulation IL1A TNF 21251215 2509665 Nox2 and Nox4 siRNA significantly attenuated *induced* ROS and upregulation of [IL-1ß] and IL-6 in cardiomyocytes . Positive_regulation IL1A TNF 21290470 2359938 Moreover , expression of E-selectin , IL-6 , and IL-8 was *induced* most efficiently by [IL-1ß] , while LPS and had less effect , whereas we did not find such a difference in ICAM-1 and MCP-1 expression . Positive_regulation IL1A TNF 21415860 2475454 More interestingly , the restoration of Prdx6 expression with wild-type Prdx6 , but not PLA(2)-mutant Prdx6 ( S32A ) , in Prdx6 ( KD ) cells dramatically induces the recovery of *induced* apoptosis , AA release , and [IL-1ß] production , indicating specific roles for the PLA(2) activity of Prdx6 . Positive_regulation IL1A TNF 2156928 129521 Two human hepatoma cell lines ( SK-Hep and Hep-G2 ) displayed a time- and dose dependent increase in steady state levels of NCF/IL-8 mRNA and secretion of chemotactic activity in *response* to and [IL-1] . Positive_regulation IL1A TNF 22353423 2586876 In vitro , results based on cultured DRG neurons showed that siRNA mediated inhibition of NOV enhanced [IL-1ß-] and TNF-a induced MMP-2 , MMP-9 and CCL2 expression whereas NOV addition inhibited *induced* MMP-9 expression through ß1 integrin engagement . Positive_regulation IL1A TNF 22569251 2596924 While uses IKK complexes containing both IKKa and IKKß , [IL-1ß] *induces* complexes with IKKa only ; Positive_regulation IL1A TNF 22714807 2659491 In the PS group , increased at 1 , 3 , and 5 weeks and [IL-1ß] *increased* significantly after 1 and 3 weeks of stress , and then decreased to normal levels by 5 weeks . Positive_regulation IL1A TNF 22730040 2639075 PANSS scores and plasma [IL-1ß] levels significantly decreased , but plasma and BDNF levels significantly *increased* after 11 weeks of Risp treatment . Positive_regulation IL1A TNF 22819042 2634988 Unlike normal cells , MCs expressing mutant Nlrp3 produced [IL-1ß] in *response* to lipopolysaccharide or . Positive_regulation IL1A TNF 22865690 2687454 Accompanying *induced* cyclic AMP reductions , but not [IL-1ß] , was increased cyclic AMP-PDE activity . Positive_regulation IL1A TNF 22954523 2688248 *increased* the secretion of lipase , [IL-1ß] , and IL-6 . Positive_regulation IL1A TNF 22954523 2688249 Pterostilbene treatment inhibited *induced* secretion of lipase ( P < 0.01 and P < 0.001 ) , [IL-1ß] ( P < 0.05 ) , and IL-6 ( P < 0.05 and P < 0.01 ) . Positive_regulation IL1A TNF 22985554 2674274 [IL-1ß] , IL-6 , and MDA levels in the BALF , W/D , lung injury scores , and iNOS mRNA and protein expressions *increased* and SOD in the BALF decreased significantly after intratracheal LPS injection . Positive_regulation IL1A TNF 23046548 2706512 Unopsonized IE *induced* secretion of IL-6 ( median= 622 pg/ml [ IQR=1,250-240 ] , n=9 ) but no [IL-1ß] or TNF , whereas PPS opsonized IE induced secretion of IL-1ß ( 18.6 pg/mL [ 34.2-14.4 ] ) and ( 113 pg/ml [ 421-17.0 ] ) and increased IL-6 secretion ( 2,195 pg/ml [ 4,658-1,095 ] ) . Positive_regulation IL1A TNF 23071098 2720894 Mixed-effects modeling analysis of our data was vital for ascertaining that [IL-1a] and TGF-a treatment increased the activities of more pathways than IL-6 and TNF-a and that TGF-a and *increased* p38 MAPK and c-Jun N-terminal kinase (JNK) phospho-protein levels in a synergistic manner . Positive_regulation IL1A TNF 23208413 2705386 Gene expression analyses showed that and IL-1ß *stimulate* the adipocyte expression of TNF-a , [IL-1ß] and IL-6 . Positive_regulation IL1A TNF 23223441 2736597 BCG enhanced production of MCP-1 , RANTES , IL-12 , and IL-6 in DCs , while M. bovis *promoted* secretion of [IL-1ß] , IL-10 and IL-23 . Positive_regulation IL1A TNF 23233723 2724503 Specific inhibition of miR-31 suppressed NF-?B-driven promoter luciferase activity and the basal and *induced* production of [IL-1ß] , CXCL1/growth related oncogene-a , CXCL5/epithelial derived neutrophil activating peptide 78 , and CXCL8/IL-8 in human primary keratinocytes . Positive_regulation IL1A TNF 23328930 2798701 Resveratrol inhibits *induced* [IL-1ß] , MMP-3 production in human rheumatoid arthritis fibroblast-like synoviocytes via modulation of PI3kinase/Akt pathway . Positive_regulation IL1A TNF 23328930 2798702 The present study was designed to investigate the effects of resveratrol on *induced* inflammatory cytokines production of [IL-1ß] and MMP3 in Rheumatoid arthritis ( RA ) Fibroblast-like synoviocytes ( FLS ) and further to explore the role of PI3K/Akt signaling pathway by which resveratrol modulates those cytokines production . Positive_regulation IL1A TNF 23328930 2798704 Activation of PI3K/Akt signaling pathway exists in *induced* production of [IL-1ß] and MMP3 on RA FLS , which is hampered by PI3K inhibitor LY294002 . Positive_regulation IL1A TNF 23328930 2798709 Resveratrol attenuates *induced* production of [IL-1ß] and MMP-3 via inhibition of PI3K-Akt signaling pathway in RA FLS , suggesting that resveratrol plays an anti-inflammatory role and might have beneficial effects in preventing and treating RA . Positive_regulation IL1A TNF 23365744 2712924 stimulation *caused* similar [IL-1ß] , IL-6 , and IL-8 release in all groups . Positive_regulation IL1A TNF 23435685 2760185 Vitamin D ( vitD ) and analogs have been shown to suppress *induced* [IL-1a] in human keratinocytes (KCs) . Positive_regulation IL1A TNF 23474372 2766489 The analgesic mechanisms of piracetam were related to inhibition of carrageenin- and *induced* production of [IL-1ß] as well as prevention of carrageenin induced decrease of reduced glutathione , ferric reducing ability and free radical scavenging ability in the paw . Positive_regulation IL1A TNF 23583898 2772898 Here , we show that thalidomide suppressed *induced* NF-?B activation and ATP induced [IL-1ß] secretion , but did not interrupt the production of IL-1ß , IL-6 , IL-8 , and TNF-a in response to lipopolysaccharide in CGD monocytes . Positive_regulation IL1A TNF 2363934 136627 *Induction* of fibroblast [IL-1 alpha] by IL-1 and/or may be an important mechanism amplifying IL-1 mediated biologic events at sites of local inflammation . Positive_regulation IL1A TNF 2370931 138361 The *induced* [IL-1] activity was significantly higher in rats with NTSN than those in normal controls and the other control group , consisting of preimmunized rats ( rabbit IgG ) , then given normal rabbit globulin instead of NTS . Positive_regulation IL1A TNF 2370931 138362 This cyclooxygenase inhibitor augmented *induced* [IL-1] production . Positive_regulation IL1A TNF 23840908 2816431 Systemic IL-1ß could not induce significant blood TNF-a , but induced CNS TNF-a mRNA , while systemic could *induce* [IL-1ß] in blood and brain . Positive_regulation IL1A TNF 24225954 2879500 We observed that exosomes were internalized by THP-1 cells and *induced* the production of [IL-1ß] , , and IL-6 . Positive_regulation IL1A TNF 24583856 2920144 The CA treatment also significantly reduced the mRNA and protein levels of tumor necrosis factor alpha ( TNF-a ) , interleukin-6 (IL-6) and IL-1ß at the application site , and the TNF-a production , the *induced* IL-6 and [IL-1ß] production , and TNF-a induced nuclear factor-kappa B ( NF-?B ) activation in human keratinocytes in vitro . Positive_regulation IL1A TNF 2460533 98575 and tumor necrosis factor-beta ( lymphotoxin ) *stimulate* the production of granulocyte-macrophage colony stimulating factor , macrophage colony stimulating factor , and [IL-1] in vivo . Positive_regulation IL1A TNF 2460533 98580 Using Northern blot analysis to detect tissue levels of hematopoietic growth factor-specific transcripts , and specific biologic and immunologic assays to detect the presence of colony stimulating factors in the serum , we have found that and TNF-beta *induce* the transcription and production of granulocyte-macrophage-CSF , macrophage-CSF , and [IL-1] . Positive_regulation IL1A TNF 24687687 2942942 Importantly , NKT cells were found to act as regulators of NLRP3 inflammasome signaling , as NKT-cell derived was *required* for optimal [IL-1ß] and IL-18 production by myeloid cells in response to a-galactosylceramide , by acting on the NLRP3 inflammasome priming step . Positive_regulation IL1A TNF 2469651 109548 [IL-1] was also without effect , but *increased* the proportion of HLA-DR+ cells in both CB and adult peripheral blood ( PBL ) -derived T lymphoblasts . Positive_regulation IL1A TNF 24699803 2938770 In ARPE-19 cells , *induced* proinflammatory gene expression of [interleukin (IL)-1ß] , IL-6 , and monocyte chemotactic protein-1 was decreased by 35.0 % , 68.8 % , and 62.5 % , respectively , with MGP pretreatment , which was primarily due to the diminished mitogen activated protein kinase activation and subsequent reduction of nuclear factor ?-B activation . Positive_regulation IL1A TNF 24928389 2946778 however , [IL-1ß] does not *induce* secretion . Positive_regulation IL1A TNF 2493383 107975 , which is a potent inducer of IL 1 , also *enhanced* [IL 1] production following stimulation with suboptimal doses of the immune complex . Positive_regulation IL1A TNF 2496917 109704 There was no evidence , however , that the production of [IL-1] was *required* for macrophage activation by in combination with rMu-IFN-gamma . Positive_regulation IL1A TNF 2511244 121757 [IL-1 alpha] and IL-1 beta mRNA were *induced* with LPS or . Positive_regulation IL1A TNF 2511244 121758 If added simultaneously CHX blocked *induced* [IL-1] gene transcription , suggesting that TNF may induce factors required for IL-1 gene transcription . Positive_regulation IL1A TNF 2523925 109921 Although IL-4 or did not *induce* significant B cell [IL-1] expression , they both caused a modest , but reproducible enhancement when added in combination with IL-2 . Positive_regulation IL1A TNF 2523936 109933 Because *induces* membrane [IL-1] in fibroblasts , it is possible to speculate that the effects of TNF on fibroblasts are due to induction of IL-1 . Positive_regulation IL1A TNF 2569055 115918 In rheumatoid arthritis , may be the main *inducer* of [IL-1] , and anti-TNF alpha agents may be useful in treatment . Positive_regulation IL1A TNF 2788206 116831 Pretreatment of mice with DEX protected against the depression of liver cytochrome P-450 by LPS or TNF but not by IL-1 , suggesting that IL-1 directly depresses cytochrome P-450 and that DEX acts by inhibiting [IL-1] synthesis in vivo *induced* by LPS or . Positive_regulation IL1A TNF 2961377 84138 Recombinant [IL-1] had no effect on receptor expression , but recombinant *increased* CR1 and CR3 expression with kinetics similar to the supernatants . Positive_regulation IL1A TNF 3056398 100793 Since , the effect of TNF was not inhibited by neutralization with antibody to IL-1 alpha and IL-1 beta , it seems that the mechanism is not mediated by endogenous [IL-1] *induced* by . Positive_regulation IL1A TNF 3116078 79153 Endothelial cell membrane [IL-1] activity was *induced* within 24 hr of culture with or lipopolysaccharide , and increased up to 72 hr of incubation . Positive_regulation IL1A TNF 3261295 96021 This suggests that PAF is synthesized by the same pathway in *response* to or [IL-1] . Positive_regulation IL1A TNF 3262629 97887 The [IL 1] and *induction* of EC adhesivity was both concentration ( threshold concentration 1 U/ml ) and time dependent ( peak 4-6 h ) , reversible within 24 h , and blocked by a protein synthesis inhibitor . Positive_regulation IL1A TNF 3283235 92037 We found that aerosolized murine rIFN-gamma or recombinant human *increased* [IL-1] production by both alveolar macrophages and blood monocytes for at least 5 days after administration . Positive_regulation IL1A TNF 3494060 72242 FS-4 cells did not secrete soluble [IL 1] in *response* to . Positive_regulation IL1A TNF 3494060 72244 Dexamethasone suppressed the synthesis of *induced* [MA-IL 1] . Positive_regulation IL1A TNF 3494060 72245 The ability of to *induce* [IL 1] synthesis in FS-4 fibroblasts at the transcriptional level was confirmed by S1 nuclease protection assay . Positive_regulation IL1A TNF 3494060 72248 Induction with TNF resulted in the appearance of IL 1-alpha mRNA and a very significant increase in IL 1-beta mRNA , indicating that *induces* the synthesis of both [IL 1-alpha] and IL 1-beta in FS-4 cells . Positive_regulation IL1A TNF 3497981 77891 Recombinant *caused* [IL-1] release by 4 hr with maximal levels of 17 U/ml by 24 hr ; Positive_regulation IL1A TNF 7473001 331452 The results indicate that *induces* production of cell associated [IL-1] in gingival fibroblasts , which can be upregulated by a PKC dependent pathway . Positive_regulation IL1A TNF 7532161 292025 [IL-1 alpha] production by PCI cells was *up-regulated* by . Positive_regulation IL1A TNF 7534264 296902 Immunocytochemistry of frozen sections from sponges showed that E-selectin expression was *up-regulated* markedly by and PHA at 5 hr , only moderately by [IL-1 alpha] at 5 hr , and not at all by PMA at 5 hr . Positive_regulation IL1A TNF 7583580 333553 We show that physiological concentrations of HDLs inhibit or [interleukin-1 (IL-1)] *induction* of these leukocyte adhesion molecules in a concentration dependent manner . Positive_regulation IL1A TNF 7621586 315616 Similarly , TGF-alpha , interferon-gamma (IFN-gamma) , IL-6 , and substantially *increased* HaCAT cell [IL-1 alpha] , but had no effect on the IL-1Ra , with a concomitant reduction in the icIL-1Ra : IL-1 alpha ratio . Positive_regulation IL1A TNF 7681061 214197 These results indicate that the *mediated* induction of [IL-1] can be entirely accounted for by stabilization of this mRNA . Positive_regulation IL1A TNF 7686496 222172 Intracellular [IL-1 alpha] and IL-1 beta levels were markedly *enhanced* by IL-1 beta and . Positive_regulation IL1A TNF 7693807 234227 Furthermore , although , preincubation of bEND.3 cells with IFN-gamma modestly increases the induction of ICAM-1 and VCAM-1 in *response* to and [IL-1] , it dramatically reduces the TNF-alpha , IL-1 , and LPS induced expression of MAdCAM-1 . Positive_regulation IL1A TNF 7775269 308915 Cytogenin *enhanced* productions of [IL-1 alpha] by macrophages and IFN gamma and GM-CSF by spleen cells although it did not enhanced production of by macrophages and IL-6 by macrophages and spleen cells . Positive_regulation IL1A TNF 7797621 314049 [IL-1 alpha] , IL-6 and mRNA levels in the hippocampus *increased* within 6 h and remained elevated for 8 days . Positive_regulation IL1A TNF 7843904 294080 These results demonstrate that both IL-1 alpha and could *induce* keratocytes to produce nanogram levels of IL-6 but [IL-1 alpha] was a 30-fold more effective inducer . Positive_regulation IL1A TNF 7851026 294334 also *up-regulated* production of [IL-1 alpha] , IL-1 beta , IL-1Ra and IL-6 by monocytes , but the variability in the results of cells cultured from the same individuals on different occasions was greater . Positive_regulation IL1A TNF 7853198 294791 Combined treatment of human umbilical endothelial cells with TNF-alpha and the protein kinase C ( PKC ) activator 12-O-tetradecanoylphorbol 13-acetate ( TPA ) suppressed the *induced* production of [IL-1 alpha] . Positive_regulation IL1A TNF 7853198 294792 Pretreatment with TPA for 15 min was enough to suppress the *induced* [IL-1 alpha] production . Positive_regulation IL1A TNF 7853198 294793 Pretreatment for 15 min with other PKC activators such as aplysiatoxin or teleocidin , also inhibited the *induced* [IL-1 alpha] production . Positive_regulation IL1A TNF 7879702 287698 Human recombinant and the calcium ionophores A23187 and ionomycin *induced* a concentration dependent increase of cell associated [IL-1] but failed to cause release of IL-1 at concentrations producing maximal stimulation of cell associated IL-1 . Positive_regulation IL1A TNF 7962270 279365 Expression of E-selectin on endothelial cells was *induced* only by [IL-1 alpha] , not by IFN gamma or . Positive_regulation IL1A TNF 8175024 255499 Recombinant [interleukin-1 (IL-1)] and tumor necrosis factor-alpha (TNF-alpha) can *induce* endogenous mRNA expression and stimulate proliferation of epithelial ovarian cancer cells . Positive_regulation IL1A TNF 8186322 256683 Regulation of IL-1 alpha expression in human keratinocytes : transcriptional *activation* of the [IL-1 alpha] gene by , LPS , and IL-1 alpha . Positive_regulation IL1A TNF 8190839 258665 To test the possibility of central *induction* of [IL-1] by , mice pretreated with IL-1 receptor antagonist ( IL-1ra , 1.8 micrograms/mouse , ICV ) were injected with 90 ng TNF alpha . Positive_regulation IL1A TNF 8283056 247450 In vivo , decreased the binding of TNF ( > 88 % ) , G-CSF ( > 89 % ) , and IL-1 ( > 73 % ) within 30 min , but *increased* [IL-1] binding ( > 4.8-fold ) after 10 h . Positive_regulation IL1A TNF 8322145 223208 The present results suggest that TNF and [IL-1] may regulate amino acid transport in skeletal muscle and that the effect of , but not that of IL-1 , is at least partly *mediated* by glucocorticoids . Positive_regulation IL1A TNF 8331299 223599 *induces* [interleukin-1 alpha] and interleukin-1 receptor antagonist production by cultured human keratinocytes . Positive_regulation IL1A TNF 8331299 223601 Only *induced* IL-1ra and [IL-1 alpha] production . Positive_regulation IL1A TNF 8334682 223771 These data indicate that the up-regulation of [IL-1] seen in monocytes following L-MTP-PE exposure may be *due* in part to the production of . Positive_regulation IL1A TNF 8387093 217935 In cells of the fibroblastoid line SV-80 , rapid down-modulation of TNF binding in *response* to itself , or to [IL-1] , was followed by a gradual recovery of binding , which occurred even in the continuous presence of the cytokines . Positive_regulation IL1A TNF 8394516 228330 These data indicate that [IL-1 alpha] induced HLA class II ( DR ) antigen up-regulation in ZR-75-1 cells is partially *mediated* by and that IL-1 alpha induced HLA class I and class II ( DR ) antigen up-regulation in ZR-75-1 human breast cancer cells in vitro are mediated by different mechanisms . Positive_regulation IL1A TNF 8454591 215288 Deletion analysis of the 5'-flanking region of the TSG6 DNA linked to the chloramphenicol acetyltransferase reporter gene revealed that a construct containing TSG6 DNA from positions -165 to +78 could be transcriptionally *activated* by [interleukin(IL)-1] , and to a lesser extent by , upon transfection into FS-4 fibroblasts . Positive_regulation IL1A TNF 8589269 342385 There was an early increase in IL-6 , soluble receptors of , and in IL-1 receptor antagonist in both groups , but no detectable *increase* in plasma [IL-1] or TNF . Positive_regulation IL1A TNF 8592105 341984 Furthermore , TNF-alpha induced LIF mRNA is blocked by the IL-1 receptor antagonist , whereas IL-1 induced LIF mRNA is not affected by TNF-alpha antibodies , suggesting that first induces IL-1 , and [IL-1] subsequently *induces* LIF . Positive_regulation IL1A TNF 8592105 341988 These data suggest that *induces* SP in sympathetic ganglia through the sequential inductions of [IL-1] and LIF . Positive_regulation IL1A TNF 8649201 366471 [IL-1 alpha] and *increase* EC-adhesiveness for leukocytes by stimulating surface expression of ICAM-1 ( intercellular adhesion molecule 1 , CD54 ) , VCAM-1 ( vascular cell adhesion molecule 1 , CD106 ) and E-selectin ( CD62E ) . Positive_regulation IL1A TNF 8702551 375486 The *induction* of [IL-1alpha] by can also be decreased by growth in 3 % oxygen as compared to growth in 21 % O2 ; Positive_regulation IL1A TNF 8702551 375490 These findings indicate that both Mn-SOD and O2 may regulate the levels of a cellular oxidant involved in both basal and *induced* [IL-1alpha] expression , presumably superoxide . Positive_regulation IL1A TNF 8809683 383149 stimulation *increased* [IL-1 alpha] production by both cell types and exhibited synergy with interferon gamma (IFN gamma) , although the latter had no effect by itself . Positive_regulation IL1A TNF 8979262 403700 The relationship between altered membrane composition , eicosanoids and *induced* [IL1] and IL6 production in macrophages of rats fed fats of different unsaturated fatty acid composition . Positive_regulation IL1A TNF 9046030 416700 The effects of different dietary fats on peritoneal macrophage plasma membrane fluidity , intracellular cyclic AMP ( cAMP ) production , GTP hydrolysis and TNF binding and *induced* [IL1] and IL6 production was investigated . Positive_regulation IL1A TNF 9209508 441110 The IL-6 response of parasitized astroglia was up-regulated by external tumor necrosis factor (TNF)-alpha and transforming growth factor (TGF)-beta 1 , with only *enhancing* simultaneous release of [IL-1] . Positive_regulation IL1A TNF 9282830 451532 [Interleukin-1 (IL-1)] and IL-6 were *induced* in monocytes by all superantigens , whereas was induced in T cells and by some superantigens , also in monocytes . Positive_regulation IL1A TNF 9375973 465366 In contrast approximately three fold more IL-8 was *induced* by [IL-1alpha] than by TNFalpha whereas significant RANTES production was induced only by . Positive_regulation IL1A TNF 9439980 475064 Curcumin inhibits [IL1 alpha] and *induction* of AP-1 and NF-kB DNA binding activity in bone marrow stromal cells . Positive_regulation IL1A TNF 9439980 475068 Since both AP-1 ( TRE ) and NF-kB ( kB ) binding motifs are present in the promoter of MCP-1/JE gene , we examined the effect of curcumin on [IL1 alpha-] and induced *activation* of ubiquitous transcription factors AP-1 and NF-kB by electrophoretic mobility shift assay and Western blotting . Positive_regulation IL1A TNF 9448041 483773 The level in the supernatants significantly increased at 120 min after allergen stimulation , and the [interleukin (IL)-1beta] level *increased* in 4 of 15 samples . Positive_regulation IL1A TNF 9558730 500201 that *induced* [IL1] and IL6 production relate in a positive curvilinear fashion to linoleic acid intake ; Positive_regulation IL1A TNF 9575340 502657 The results suggest that brain [IL-1] *induces* peripheral production of IL-6 , but not of , through autonomic nervous system activation . Positive_regulation IL1A TNF 9691088 523117 Reverse transcriptase polymerase chain reaction was used to confirm that + LPS + IFN-gamma *stimulates* the expression of both [IL-1alpha] and IL-1beta in human islets . Positive_regulation IL1A TNF 9770330 538826 However , in vivo neutralization of TNF-alpha did not result in decreased IL-1 bioactivity or immunoreactivity , suggesting that there is no dominant *dependent* [IL-1] release in this model . Positive_regulation IL1A TNF 9811056 545535 The synergistic *induction* of [IL-1alpha] by and IL-11 was completely inhibited by a potent inhibitor of all isoforms of PKC , GF109203X . Positive_regulation IL1A TNF 9825772 549222 VCAM-1 expression on SK-N-SH was *induced* by [IL-1alpha] and TNF alpha and IFN gamma synergized with in this respect on both NB cell lines . Positive_regulation IL1B ABCA1 15578659 1361373 ATP binding cassette transporter is *required* for the release of [interleukin-1beta] by P2X7 stimulated and lipopolysaccharide primed mouse Schwann cells . Positive_regulation IL1B ABCD1 15793118 1386919 In protein measurement studies , DAMB and *up-regulated* production of [IL-1beta] ( P < 0.05 ) , decreased the IL-1ra/IL-1beta ratio , and up-regulated the production of MCP-1 and MIP-1beta . Positive_regulation IL1B ABCD2 15793118 1386920 In protein measurement studies , DAMB and *up-regulated* production of [IL-1beta] ( P < 0.05 ) , decreased the IL-1ra/IL-1beta ratio , and up-regulated the production of MCP-1 and MIP-1beta . Positive_regulation IL1B ABCD3 15793118 1386921 In protein measurement studies , DAMB and *up-regulated* production of [IL-1beta] ( P < 0.05 ) , decreased the IL-1ra/IL-1beta ratio , and up-regulated the production of MCP-1 and MIP-1beta . Positive_regulation IL1B ABCD4 15793118 1386922 In protein measurement studies , DAMB and *up-regulated* production of [IL-1beta] ( P < 0.05 ) , decreased the IL-1ra/IL-1beta ratio , and up-regulated the production of MCP-1 and MIP-1beta . Positive_regulation IL1B ACAN 11174072 763234 [Interleukin-1beta] *induces* different gene expression of stromelysin , and tumor-necrosis-factor stimulated gene 6 in human osteoarthritic chondrocytes in vitro . Positive_regulation IL1B ACD 9234597 445306 In addition , circulating TNF alpha is elevated in rheumatoid arthritis ( RA ) , [IL-1 beta] serum levels are significantly *increased* in RA with and RA patients treated in vivo with antibodies ( Abs ) to TNF alpha show disease improvement , including an increase in Hb values . Positive_regulation IL1B ACD 9386984 466438 These findings suggest that systemic TNF alpha or [IL-1 beta] are not involved in the erythropoietin *response* to . Positive_regulation IL1B ACE 12228766 988126 LPS induced [IL-1beta] generation was not *reduced* by the inhibitor . Positive_regulation IL1B ACE 12626369 1066716 Furthermore , the inhibitor *reduced* the LPS induced increase in the hepatic concentration of [IL-1beta] protein . Positive_regulation IL1B ACE2 19411314 2095744 Phorbol ester , ionomycin , endotoxin , and [IL-1beta] and TNFalpha acutely *induced* release , further supporting that ADAM17 and ADAM10 regulate ACE2 cleavage . Positive_regulation IL1B ACSM3 15159698 1252753 Increase of the [IL-1 beta] and IL-6 levels in CSF in patients with vasospasm *following* aneurysmal . Positive_regulation IL1B ADA 16860713 1588838 These drugs caused a marked reduction in MPO activity , as well as [IL-1beta] and TNFalpha levels ( P < 0.01 ) , but only Tacrolimus *inhibited* activity ( P < 0.01 ) . Positive_regulation IL1B ADAM10 22792188 2628340 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B ADAM11 22792188 2628341 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B ADAM12 22792188 2628342 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B ADAM15 22792188 2628343 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B ADAM17 15641051 1362980 [IL-1beta-] and TNFalpha mediated induction of IL-6R shedding in osteoblast-like cells is at least partly *dependent* on activation . Positive_regulation IL1B ADAM17 22792188 2628344 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B ADAM18 22792188 2628345 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B ADAM19 22792188 2628346 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B ADAM2 22792188 2628347 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B ADAM20 22792188 2628348 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B ADAM21 22792188 2628349 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B ADAM22 22792188 2628350 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B ADAM23 22792188 2628351 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B ADAM28 22792188 2628352 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B ADAM29 22792188 2628353 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B ADAM30 22792188 2628354 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B ADAM32 22792188 2628339 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B ADAM33 22792188 2628338 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B ADAM5 22792188 2628355 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B ADAM6 22792188 2628356 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B ADAM7 22792188 2628357 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B ADAM8 22792188 2628358 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B ADAM9 22792188 2628359 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B ADCYAP1 16095565 1448116 Furthermore , [IL-1beta] stimulated IL-6 promoter activity in the osteoblastic cell line MC3T3-E1 stably transfected with a human IL-6 promoter/luciferase construct , and both VIP , and the related neuropeptide , *increased* the effect of IL-1beta in a synergistic manner . Positive_regulation IL1B ADIPOQ 15905315 1426882 however , leptin at 100 ng/ml and at 0.1 and/or 0.5 microg/ml significantly *increased* the release of [IL-1beta] , IL-6 , TNFalpha , and PGE2 from human placenta and adipose tissue . Positive_regulation IL1B ADIPOQ 17148740 1661564 More specifically , we demonstrate that *induces* [IL-1beta] and IL-8 from THP-1 macrophage cell line . Positive_regulation IL1B ADM 15576460 1368461 *increased* initial secretion of MIF and [IL-1beta] from both nonstimulated and LPS stimulated cells , and it also increased basal and LPS induced IL-6 secretion of the cells by 2- to 15-fold . Positive_regulation IL1B ADM 15930287 1414463 The proinflammatory cytokine [interleukin 1beta] and hypoxia cooperatively *induce* the expression of in ovarian carcinoma cells through hypoxia inducible factor 1 activation . Positive_regulation IL1B AGK 16651715 1558231 Mouse *up-regulated* pro-matrix-metalloproteinase-9 , vascular endothelial growth factor , transforming growth factor-beta , IL-6 , and [IL-1beta] production in the early stage of wound tissue . Positive_regulation IL1B AGO2 9691696 523131 A combination of the high production of *induced* [IL-1 beta] and PGA stimulated IL-2 is more specific to patients with infiltrative pulmonary tuberculosis . Positive_regulation IL1B AGTR2 17884764 1797364 receptors are *involved* in alpha-TNF and [IL1 beta] secretions in cardiac fibroblasts . Positive_regulation IL1B AHR 14725856 1198186 Nuclear run-on experiments were performed in SCC-12 cells to determine if the *dependent* increases in [IL-1beta] expression were due to transcriptional activation of the IL-1beta gene . Positive_regulation IL1B AHR 15019843 1221014 We have previously shown that TCDD stimulated *dependent* [IL-1beta] expression in human keratinocytes is due to posttranscriptional regulation involving mRNA stabilization . Positive_regulation IL1B AHSA1 16297883 1502769 Dioscorin also stimulated multiple signaling molecules ( NF-kappaB , ERK , JNK , and ) and *induced* the expression of cytokines ( TNF-alpha , [IL-1beta] , and IL-6 ) in murine RAW 264.7 macrophages . Positive_regulation IL1B AHSA1 17395477 1728134 In the present study the quantitative *role* of p42/44 and in the production of TNF-alpha , [IL-1beta] and IL-12 by murine peritoneal macrophages , in vitro , on treatment with Concanavalin A ( ConA ) has been investigated . Positive_regulation IL1B AHSA1 20590569 2285780 Cisplatin significantly increased endocannabinoid anandamide content , activation of and JNK mitogen *activated* protein kinases ( MAPKs ) , apoptotic and poly ( ADP-ribose ) polymerase dependent cell death , enhanced inflammation ( leucocyte infiltration , tumour necrosis factor-alpha and [interleukin-1beta] ) and promoted oxidative/nitrosative stress [ increased expressions of superoxide generating enzymes ( NOX2 ( gp91phox ) , NOX4 ) , inducible nitric oxide synthase and tissue 4-hydroxynonenal and nitrotyrosine levels ] in the kidneys of mice , accompanied by marked histopathological damage and impaired renal function ( elevated creatinine and serum blood urea nitrogen ) 3 days following its administration . Positive_regulation IL1B AHSG 18335040 1881506 treatment *induced* TNF and [IL1B] mRNA expression in THP1 cells ( p < 0.05 ) . Positive_regulation IL1B AKT1 12483539 1024813 Exogenous expression of either SHPS-1 mutants that lack SHP-2 binding function or a dominant negative mutant of SHP-2 markedly inhibited the *activation* of Erk 1/2 and by [IL-1beta] , whereas wild type SHPS-1 did not . Positive_regulation IL1B AKT1 16038626 1437396 SF significantly prevented Abeta induced increases in [IL-1beta] and p38 MAPK *activation* and also Abeta induced changes in phospho-ERK and expression levels . Positive_regulation IL1B AKT1 18684863 1973556 Simvastatin treatment was found to activate protein kinase B (PKB)/c-akt , a primary effector of PI3K , and ectopic expression of constitutively active was *sufficient* to induce [IL-1beta] release . Positive_regulation IL1B AKT2 12483539 1024814 Exogenous expression of either SHPS-1 mutants that lack SHP-2 binding function or a dominant negative mutant of SHP-2 markedly inhibited the *activation* of Erk 1/2 and by [IL-1beta] , whereas wild type SHPS-1 did not . Positive_regulation IL1B AKT2 16038626 1437397 SF significantly prevented Abeta induced increases in [IL-1beta] and p38 MAPK *activation* and also Abeta induced changes in phospho-ERK and expression levels . Positive_regulation IL1B AKT3 12483539 1024815 Exogenous expression of either SHPS-1 mutants that lack SHP-2 binding function or a dominant negative mutant of SHP-2 markedly inhibited the *activation* of Erk 1/2 and by [IL-1beta] , whereas wild type SHPS-1 did not . Positive_regulation IL1B AKT3 16038626 1437398 SF significantly prevented Abeta induced increases in [IL-1beta] and p38 MAPK *activation* and also Abeta induced changes in phospho-ERK and expression levels . Positive_regulation IL1B ALB 8793554 381088 Human modified with 1-2 methylglyoxal residues per molecule of protein ( MGmin-HSA ) *stimulated* the synthesis and secretion of [interleukin 1 beta (IL-1 beta)] from human monocytic THP-1 cells in vitro . Positive_regulation IL1B ALDH3A2 10906442 715337 In contrast , treatment did not *induce* [IL-1beta] mRNA expression in any of the donors investigated . Positive_regulation IL1B ALOX5 10022882 590389 Reactive oxygen intermediate dependent NF-kappaB activation by [interleukin-1beta] *requires* <5-lipoxygenase> or NADPH oxidase activity . Positive_regulation IL1B ALOX5 8273590 239506 As previously reported , the <5-lipoxygenase/cyclooxygenase (5-LO/CO)> inhibitor , SKF86002 ( 30 microM ) , significantly *inhibited* both [IL-1 beta] and TNF-alpha release using either stimulus . Positive_regulation IL1B ALOX5 9187965 437092 Differential effects of cell density on <5-lipoxygenase (5-LO)> , five-lipoxygenase *activating* protein ( FLAP ) and [interleukin-1 beta (IL-1 beta)] expression in human neutrophils . Positive_regulation IL1B ANG 10999742 734345 In an in vitro study , [interleukin-1beta] and tumor necrosis factor-alpha *induced* mRNA expression in colon cancer cells in a dose- and time dependent manner , and these cytokines significantly upregulated the expression of angiogenin mRNA , especially in colon cancer cells rather than in other cells in the stroma of tumor tissues ( fibroblasts , tumor infiltrating lymphocytes , macrophages ) . Positive_regulation IL1B ANG 12802423 1101308 isolated from cow milk *induces* the production of cytokines [IL-1beta] , IL-6 , and TNF-alpha in human leukocytes ; Positive_regulation IL1B ANGPT2 14617687 1209980 The present study was performed to investigate whether brain *contributes* to the fever and [IL-1beta] production in the rat brain induced by i.c.v . Positive_regulation IL1B ANGPT2 14766380 1207577 Since *contributes* to the LPS induced production of cytokines such as [IL-1beta] , as described above , it is possible that the generation of TNF by LPS involves an action of ANG II , too , and that this TNF production leads to the LPS induced hypothermia . Positive_regulation IL1B ANGPT2 18827978 2012764 In addition , synergistically *stimulated* the induction of COX-2 by pro-inflammatory cytokines , [IL-1beta] , or TNF-alpha . Positive_regulation IL1B APLN 20664951 2298194 stimulated the proliferation of chondrocytes and significantly *increased* mRNA levels of MMP-1 , -3 , -9 and [IL-1beta] in vitro . Positive_regulation IL1B APOB 11583711 865798 VK-19911 ( Pyridine , 4- [ 4- ( 4-fluorophenyl ) -1- ( 4-piperidinyl ) -1H-imidazol-5-yl ] -dihydrochloride ) , a specific inhibitor of p38 alpha , prevented the *induction* of TNFalpha and [IL-1 beta] by oxidized in a dose dependent manner . Positive_regulation IL1B APOB 1558837 184570 Oxidized also *stimulated* the release of [interleukin-1 beta] from monocytes . Positive_regulation IL1B APOB 16087165 1443234 Very low-density *induces* [interleukin-1beta] expression in macrophages . Positive_regulation IL1B APOB 1629217 191849 The purpose of the present study was to determine whether modified could also *induce* macrophage release of [interleukin 1 beta (IL-1 beta)] , a cytokine which enhances vascular smooth muscle cell proliferation , another feature of the atherosclerotic process . Positive_regulation IL1B APOB 16505590 1529426 Neither native nor oxidized LDL ( OxLDL ) significantly *increased* [IL-1beta] release . Positive_regulation IL1B APOB 1816321 177440 , acetylated-LDL , or malondialdehyde-LDL did not *induce* [IL-1 beta] mRNA expression or affect the expression in response to lipopolysaccharide (LPS) . Positive_regulation IL1B APOB 18167199 1838735 However , [interleukin 1 beta (IL-1 beta)] further increased intracellular cholesterol level in the *presence* of by increasing both LDL receptor mRNA and protein expression in HepG2 . Positive_regulation IL1B APOB 7704977 297595 In conclusion , human macrophages are efficiently *activated* by , as reflected by the release of [IL-1 beta] and TNF alpha and by the release of oxygen active radicals . Positive_regulation IL1B APOB 8014577 262525 Oxidized *induce* the release of [interleukin-1 beta (IL-1 beta)] from human peripheral blood mononuclear cells , a process that may contribute to atherogenesis . Positive_regulation IL1B APOB 8014577 262528 High Cu2+ to LDL ratios promoted extensive TBARS formation and these were the most potent *activators* of [IL-1 beta] release , although LDL with TBARS greater than 50 nmol/mg protein were cytotoxic and IL-1 beta release was diminished . Positive_regulation IL1B APOB 8014577 262529 Accordingly , dialysis of oxidized LDL removed nearly all aldehydes and rendered the unable to *induce* [IL-1 beta] release . Positive_regulation IL1B APOB 8274477 247107 Marked IL-8 induction by did not *require* [IL-1 beta] generation in THP-1 cells . Positive_regulation IL1B APOE 15181248 1255686 However , exogenous in the absence of Abeta *stimulated* production of the pro-inflammatory cytokine [interleukin-1beta] in an isoform dependent manner , with apoE4 inducing a significantly greater response than apoE3 . Positive_regulation IL1B APP 20302643 2238043 Moreover , divergent dependent signaling is *required* for increased secretion of both [IL-1beta] and Abeta1-40 as a component of the adhesion dependent change in phenotype . Positive_regulation IL1B APP 7693853 234250 This study was undertaken to determine whether *induce* the synthesis of [interleukin 1 beta (IL-1 beta)] and its specific antagonist , IL-1 receptor antagonist (IL-1Ra) , in human peripheral blood mononuclear cells ( PBMC ) . Positive_regulation IL1B AQP4 16987239 1617783 [Interleukin-1beta] *induces* the expression of through a nuclear factor-kappaB pathway in rat astrocytes . Positive_regulation IL1B AREG 17670913 1780546 The bioinformatic data were validated in experiments which showed that , but not epidermal growth factor , *results* in transcriptional up-regulation of IL-1alpha and [IL-1beta] . Positive_regulation IL1B AREGB 15685553 1370981 expression is *induced* in isolated hepatocytes by [interleukin 1beta] and prostaglandin E ( 2 ) , but not by hepatocyte growth factor , interleukin 6 , or tumor necrosis factor alpha . Positive_regulation IL1B ARG1 19052845 2029723 The [IL-1 beta] inducible ADAMTS9 expression was *inhibited* by NFAT inhibitors , FK506 and <11Arg> ( 11R ) -VIVIT . Positive_regulation IL1B ARG2 19052845 2029724 The [IL-1 beta] inducible ADAMTS9 expression was *inhibited* by NFAT inhibitors , FK506 and <11Arg> ( 11R ) -VIVIT . Positive_regulation IL1B ARSA 15024038 1257102 The area of *induced* gastric lesions , gastric blood flow ( GBF ) , expression of mRNA and protein of leptin and plasma leptin , gastrin , [interleukin-1beta] , and tumor necrosis factor-alpha levels were examined . Positive_regulation IL1B ASIP 1919001 168463 Cleavage at *results* in the generation of mature , biologically active [IL-1 beta] . Positive_regulation IL1B ASS1 15820746 1393731 In the present study , using Caco-2 cells , a human enterocyte line , we demonstrate that [IL-1beta] rapidly *induces* the expression of the gene at a transcriptional level through NF-kappaB activation . Positive_regulation IL1B ATF4 19648113 2143237 Injury induced platelet derived growth factor receptor-alpha expression mediated by [interleukin-1beta (IL-1beta)] release and cooperative *transactivation* by NF-kappaB and : IL-1beta facilitates HDAC-1/2 dissociation from promoter . Positive_regulation IL1B ATP5O 17295899 1698786 The N-terminus domain of the a2 isoform of vacuolar can *regulate* [interleukin-1beta] production from mononuclear cells in co-culture with JEG-3 choriocarcinoma cells . Positive_regulation IL1B ATP5O 20206126 2229797 We show here that endogenous and plant derived inhibitors of the Na ( + ) /K ( + ) <-ATPase> , i.e. the cardiac glycosides ouabain and digitoxin , *inhibit* [IL-1beta-] and IL-6 induced APP expression in human hepatoma cells and primary human hepatocytes ( PHH ) at nanomolar concentrations . Positive_regulation IL1B ATP8A2 9257931 448558 Submaximal stimuli used for further experiments were IFNgamma 100 u ml(-1) , IL-1beta 1 u and LPS 10 microg ml(-1) to *induce* both the iNOS and COX-2 pathways , and [IL-1beta] 3 u ml(-1) to induce COX-2 without iNOS activity . Positive_regulation IL1B AVP 8646561 343010 These results suggest that not only CRH but also may *mediate* the [IL-1 beta] stimulation of ACTH secretion in the rat . Positive_regulation IL1B BAI1 18039391 1836183 Furthermore , *increased* cytoplasmic IkappaBalpha proteins in [IL-1beta-] and TNF-alpha activated HMC-1 . Positive_regulation IL1B BAI2 18039391 1836184 Furthermore , *increased* cytoplasmic IkappaBalpha proteins in [IL-1beta-] and TNF-alpha activated HMC-1 . Positive_regulation IL1B BAI3 18039391 1836185 Furthermore , *increased* cytoplasmic IkappaBalpha proteins in [IL-1beta-] and TNF-alpha activated HMC-1 . Positive_regulation IL1B BCL2 15818317 1393431 Overexpression of human in syngeneic rat donor lungs preserves posttransplant function and *reduces* intragraft caspase activity and [interleukin-1beta] production . Positive_regulation IL1B BCL3 12483727 1024846 Endogenous expression was *required* for [IL-1beta] induction of MMP-1 gene expression . Positive_regulation IL1B BGN 19605353 2123843 The objective of this study was to define the *role* of in the synthesis and activation of [IL-1beta] . Positive_regulation IL1B BGN 19605353 2123848 Here we show that in macrophages , soluble *induces* the NLRP3/ASC inflammasome , activating caspase-1 and releasing mature [IL-1beta] without the need for additional costimulatory factors . Positive_regulation IL1B BLM 19218193 2071854 Reduction of uric acid levels using the inhibitor of uric acid synthesis allopurinol or uricase leads to a decrease in *induced* [IL-1beta] production , lung inflammation , repair , and fibrosis . Positive_regulation IL1B BMP7 12233782 988754 Our results demonstrate that expression is *induced* by [IL-1beta] and suggest that this expression , like that of HAS-2 , may play a role as a protective mechanism against inflammatory cytokines . Positive_regulation IL1B BSG 19509148 2098344 In addition , we provide evidence that suppression *results* in decreased [interleukin 1beta (IL-1beta)] , IL-6 , and IL-8 cytokine production , in vitro and in vivo . Positive_regulation IL1B BTK 16517732 1530891 In this study , we have investigated the *role* of both in signaling via another TLR ( TLR2 ) and in the production of other proinflammatory cytokines such as [IL-1beta] , IL-6 , and IL-8 . Positive_regulation IL1B C3 19684087 2132985 The mechanism leading to the development of these symptoms may correlate with the recruitment of neutrophils and/or the production of [IL-1beta] *induced* by . Positive_regulation IL1B C3 8617973 353949 Neither nor C3a desArg alone *induced* detectable protein or mRNA levels for TNF-alpha and [IL-1 beta] . Positive_regulation IL1B C3 8617973 353955 In contrast , in adherent PBMC , at 5 to 20 microgram/ml *enhanced* LPS induced TNF-alpha ( 75-188 % increase , p less than 0.001 ) and [IL-1 beta] ( 119-274 % increase , p less than 0.001 ) synthesis . Positive_regulation IL1B C5 10927032 719243 However , in the presence of low concentrations of LPS ( 50 ng/mL ) , both [IL-1beta] and TNF-alpha were *stimulated* by 1 nM . Positive_regulation IL1B C5 12562384 1053788 In this study , we used a primary human RPE cell line ( RPE43 ) and found that *induces* increased expression of [IL-1beta] , IL-6 , MCP-1 and GM-CSF mRNAs as well as IL-8 mRNA . Positive_regulation IL1B C5 12567272 1057138 Finally , piperlactam S inhibited the *stimulated* release of tumor necrosis factor-alpha and [interleukin-1beta] . Positive_regulation IL1B C5 1769685 174859 The transcription of [IL-1 beta] , however , can be *induced* by alone . Positive_regulation IL1B CA2 10857757 704521 We investigated the *role* of protein kinase C ( PKC ) and in the induction of PMN [IL-1beta] gene expression by GM-CSF . Positive_regulation IL1B CA2 12660148 1105968 We clarify an essential *role* for in ATP induced [IL-1beta] secretion and indicate an additional role of P2X7 receptors as enhancers of the secretory apparatus by which IL-1beta is released . Positive_regulation IL1B CADM1 9409229 471437 In cultured human smooth muscle cells from coronary arteries and saphenous veins , tumor necrosis factor-alpha (TNF-alpha) and [interleukin-1 beta (IL-1 beta)] *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation IL1B CADM2 9409229 471429 In cultured human smooth muscle cells from coronary arteries and saphenous veins , tumor necrosis factor-alpha (TNF-alpha) and [interleukin-1 beta (IL-1 beta)] *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation IL1B CADM3 9409229 471428 In cultured human smooth muscle cells from coronary arteries and saphenous veins , tumor necrosis factor-alpha (TNF-alpha) and [interleukin-1 beta (IL-1 beta)] *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation IL1B CADM4 9409229 471430 In cultured human smooth muscle cells from coronary arteries and saphenous veins , tumor necrosis factor-alpha (TNF-alpha) and [interleukin-1 beta (IL-1 beta)] *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation IL1B CALM3 10479156 643432 Thus , amphotericin B acts as an ionophore to increase [ Ca++]i and activates *mediated* expression of [IL-1beta] in human monocytes . Positive_regulation IL1B CALM3 1411792 201440 In the intracellular signal transduction mechanism for the production of [IL-1 beta] by these cells following IFN-gamma stimulation , protein kinase C and may be *involved* as second messengers . Positive_regulation IL1B CALM3 7687235 222428 Though the inhibitor *inhibits* the mRNA expression and the active molecule production of [IL-1 beta] , it does not affect those of TNF-alpha . Positive_regulation IL1B CALM3 8383862 214668 Activation of either protein kinase C or also *induced* early expression of both [IL-1 beta] and c-fos . Positive_regulation IL1B CALML3 20720515 2381269 Treatment with TAK-242 ( 10 mg/kg i.v. ) in combination with imipenem ( 1 mg/kg s.c. ) 1 h after CLP significantly increased the survival rates of mice from 17 % to 50 % ( P = 0.01 ) and suppressed *induced* increases in serum levels of [IL-1[beta] ] , IL-6 , IL-10 , and macrophage inflammatory protein 2 by 64 % , 73 % , 79 % , and 81 % , respectively ( P = 0.025 ) . Positive_regulation IL1B CAMP 15067080 1231811 In this study , we report that stimulation of LPS primed monocytes *leads* to maturation and release of [IL-1 beta] via the P2X(7) receptor . Positive_regulation IL1B CAMP 16723446 1565402 *induced* HCEC migration ( n=5 ) and secretion of IL-8 , IL-6 , [IL-1beta] , and TNF-alpha ( 2- to 23-fold , n=4-7 ) . Positive_regulation IL1B CAPN1 7499244 332645 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Positive_regulation IL1B CAPN10 7499244 332646 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Positive_regulation IL1B CAPN11 7499244 332647 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Positive_regulation IL1B CAPN12 7499244 332644 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Positive_regulation IL1B CAPN13 7499244 332655 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Positive_regulation IL1B CAPN14 7499244 332656 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Positive_regulation IL1B CAPN15 7499244 332643 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Positive_regulation IL1B CAPN2 7499244 332648 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Positive_regulation IL1B CAPN3 7499244 332649 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Positive_regulation IL1B CAPN5 7499244 332650 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Positive_regulation IL1B CAPN6 7499244 332651 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Positive_regulation IL1B CAPN7 7499244 332652 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Positive_regulation IL1B CAPN8 7499244 332653 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Positive_regulation IL1B CAPN9 7499244 332654 However , the activation of in P388D1 cells that were transiently transfected with a cDNA expression vector encoding the precursor form of IL-1 beta did not *result* in the degradation of precursor [IL-1 beta] , but did result in the processing and secretion of IL-1 alpha , implying that precursor IL-1 beta is protected from calpain degradation in vivo . Positive_regulation IL1B CARD8 11821383 928882 We demonstrate that interacts physically with caspase-1 and negatively *regulates* caspase-1 dependent [IL-1beta] generation in the THP-1 monocytic cell line . Positive_regulation IL1B CASP1 10358182 618927 Furthermore , the virus induced activation of is *required* for the efficient production of biologically active [IL-1 beta] and IL-18 . Positive_regulation IL1B CASP1 10578176 569565 In addition to the well established *role* of in the production of active [IL-1beta] and IL-18 in inflammation,4 an increasing number of reports has recently suggested that caspases may have a function outside of apoptosis . Positive_regulation IL1B CASP1 10806046 692071 Diacerhein and rhein reduce the *induced* [IL-1beta] and IL-18 activation in human osteoarthritic cartilage . Positive_regulation IL1B CASP1 11028539 739354 Inhibition of activity by Z-VAD significantly *reduced* lipopolysaccharide (LPS) and Staphylococcus aureus ( SAC ) induced release of mature [IL-1beta] in septic patients and controls . Positive_regulation IL1B CASP1 11056157 809684 Neither [IL-1beta] nor IL-18 release was *prevented* by inhibition , and IL-18 release was not induced by ICE activation itself . Positive_regulation IL1B CASP1 11246703 793283 [IL-1beta] secretion was *blocked* by the inhibitor , Z-VAD-FMK , indicating that caspase-1 is involved in not only the induction of apoptosis but also the IL-1beta secretion from A. actinomycetemcomitans infected J774.1 cells . Positive_regulation IL1B CASP1 11432859 850287 The production of bio-active [interleukin-1beta (IL-1beta)] , a pro-inflammatory cytokine , is *mediated* by activated . Positive_regulation IL1B CASP1 11821383 928881 We demonstrate that CARD-8 interacts physically with caspase-1 and negatively regulates *dependent* [IL-1beta] generation in the THP-1 monocytic cell line . Positive_regulation IL1B CASP1 12237341 989188 Because activity is *essential* for the endogenous synthesis of active [IL-1beta] , ICE overexpression represents the key signal in the AmB induced and IL-1beta mediated effects on iNOS activity . Positive_regulation IL1B CASP1 12404229 1009765 In peripheral blood mononuclear cells , inhibition of *reduced* [interleukin-1beta] secretion , whereas blockade of phagocytosis inhibited calcium induced apoptosis and interleukin-1beta release . Positive_regulation IL1B CASP1 12444148 1017335 We conclude that modulates apoptosis of both peripheral blood and inflammatory neutrophils , but is not *essential* for [IL-1beta] production in the lung . Positive_regulation IL1B CASP1 12459189 1021689 The production of bioactive [interleukin-1beta (IL-1beta)] , a pro-inflammatory cytokine , is *mediated* by activated . Positive_regulation IL1B CASP1 12459189 1021710 Nod1 enhances *induced* [IL-1beta] secretion , as well as lipopolysaccharide (LPS) induced IL-1beta secretion in transfected cells . Positive_regulation IL1B CASP1 12540519 1050544 8. This study demonstrates that injection of a selective caspase-1 inhibitor after myocardial ischaemia markedly reduced the detrimental effect conferred by hypercholesterolaemia on myocardial ischaemia-reperfusion injury by attenuating both necrotic as well as apoptotic cell death pathways through inhibition of [IL-1beta] production and *activation* of and caspase-3 . Positive_regulation IL1B CASP1 12670445 1076014 Inhibition of *reduced* IFN-gamma and [IL-1beta] levels ( by 80 and 67 % , respectively ) when heat killed S. epidermidis was added to whole human blood cultures . Positive_regulation IL1B CASP1 12704141 1082318 In addition , only the piliated wild-type strains induced *mediated* activation of [interleukin-1 beta] . Positive_regulation IL1B CASP1 12775719 1119760 In contrast to its effects on Nod1- and Cardiak dependent NF-kappa B activation , CARD6 did not interfere with *dependent* [interleukin-1 beta] secretion induced by Cardiak or Nod1 . Positive_regulation IL1B CASP1 14599623 1161292 inhibition significantly *reduced* [IL-1beta] production by SmT- and SmD infected monocytes ( P < 0.05 , n = 4 ) . Positive_regulation IL1B CASP1 15010463 1243387 The extracellular release of [IL-1beta] and IL-18 in response to anthrax LT is *dependent* , as an ICE-specific inhibitor blocks this process . Positive_regulation IL1B CASP1 15389634 1366720 Our data have evidenced the following : ( i ) addition of Efaroxan to islet cultures inhibited [IL-1beta] *activation* of ( cysteine protease IL-1beta converting enzyme ) while addition of 1400W did not ; Positive_regulation IL1B CASP1 16305880 1485995 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , [interleukin-1beta] and interleukin-6 , and *activation* of caspase-1 , caspase-3 and . Positive_regulation IL1B CASP1 16394010 1506051 A potent adjuvant monophosphoryl lipid A triggers various immune responses , but not secretion of [IL-1beta] or *activation* of . Positive_regulation IL1B CASP1 16423834 1533932 By incubation with mK13 , but not with mK1 , mK9 , or mK22 , the 35-kDa [pro-IL-1beta] was cleaved into two major products with molecular masses of 17.5 and 22 kDa , and production was *inhibited* by phenylmethylsulfonyl fluoride , a serine protease inhibitor , but not by inhibitors . Positive_regulation IL1B CASP1 16677166 1558946 Enhancement of [IL-1beta] protein release induced by hyperosmotic stress was significantly *attenuated* by an inhibitor , Z-YVAD-FMK . Positive_regulation IL1B CASP1 16861683 1588943 *mediated* activation of [interleukin-1beta (IL-1beta)] and IL-18 contributes to innate immune defenses against Salmonella enterica serovar Typhimurium infection . Positive_regulation IL1B CASP1 16886979 1596652 inhibition *reduced* the release of [IL-1beta] in organotypic slices exposed to LPS+ATP . Positive_regulation IL1B CASP1 17336692 1707647 [IL-1beta] and IL-18 are related closely , and both *require* the intracellular cysteine protease for biological activity . Positive_regulation IL1B CASP1 17404266 1721903 The release of UA-induced [IL-1beta] was significantly *inhibited* by the inhibitors of p38 MAPK , MEK1/2 , ATP binding cassette transporter , and . Positive_regulation IL1B CASP1 17404311 1721993 Aluminum hydroxide adjuvants activate and *induce* [IL-1beta] and IL-18 release . Positive_regulation IL1B CASP1 17404311 1721995 In this study , we show that Alum activates and *induce* secretion of mature [IL-1beta] and IL-18 . Positive_regulation IL1B CASP1 17459804 1731515 Secretion of the proinflammatory cytokine [IL-1beta] *requires* and Toll-like receptor (TLR) signaling . Positive_regulation IL1B CASP1 17551224 1752641 However , leptin treatment increased monocyte/macrophages production of [IL-1beta] as well as TNF-alpha , and *induced* the mRNA expression of , which is shown to mediate the conversion of latent pro-IL-1beta and pro-IL-18 to active forms . Positive_regulation IL1B CASP1 17768231 1790467 Addition of CCCP 15 min after infection blocked macrophage cell death , the *activation* of and the maturation of [IL-1beta] , without affecting uptake or escape of S. flexneri from the phagosome . Positive_regulation IL1B CASP1 1781424 175890 Probing the *role* of in [interleukin-1 beta] secretion . Positive_regulation IL1B CASP1 18081695 1983973 Altogether , these data demonstrate a dual role for the P. aeruginosa T3SS in the regulation of *mediated* [IL-1beta] production and provide new insights into the mechanisms of immune evasion by this pathogen . Positive_regulation IL1B CASP1 18242710 1877072 Taken together , these results demonstrate that simvastatin *augments* LPS induced [IL-1beta] release post-translationally , by inducing activity . Positive_regulation IL1B CASP1 18256184 1871783 We demonstrate here that Pseudomonas aeruginosa activates and *induces* [IL-1beta] secretion in infected macrophages . Positive_regulation IL1B CASP1 18362138 1912705 The activation of by the detection of bacterial products through Nod-like receptors *leads* to the secretion of mature [interleukin-1beta (IL-1beta)] and IL-18 and the induction of rapid host cell death ( pyroptosis ) . Positive_regulation IL1B CASP1 18398369 1893724 Ischemia induced increased expressions of TNF-alpha ( P < or= 0.012 ) , [IL-1beta] ( P < or= 0.017 ) , ICAM-1 ( P < or= 0.025 ) , and IL-6 ( P = 0.012 ) , and diabetes *induced* increased expression of ( P < or= 0.046 ) , VCAM-1 ( P < or= 0.027 ) , ICAM-1 ( P < or= 0.016 ) , IL-1beta ( P = 0.016 ) , and IL-6 ( P = 0.041 ) . Positive_regulation IL1B CASP1 18490713 1916918 We delineated two distinct release pathways : the well-known caspase-1 cascade mediating release of processed [IL-1beta] that was selectively *blocked* by inhibition of or panx1 , and a calcium independent , caspase-1/panx1 independent release of pro-IL-1beta that was selectively blocked by glycine . Positive_regulation IL1B CASP1 18511561 1922434 A NOD2-NALP1 complex mediates *dependent* [IL-1beta] secretion in response to Bacillus anthracis infection and muramyl dipeptide . Positive_regulation IL1B CASP1 18541743 1923578 Apoptosis associated speck-like protein containing a caspase recruitment domain (ASC) is an adaptor protein that regulates *dependent* [IL-1 beta] and IL-18 generation ; Positive_regulation IL1B CASP1 18566365 1929591 We have recently shown that alum activates and *induces* secretion of mature [IL-1beta] and IL-18 . Positive_regulation IL1B CASP1 18684863 1973559 [IL-1beta] release is *mediated* by , and simvastatin treatment resulted in increased caspase-1 activity in a Rac1/PI3K dependent manner . Positive_regulation IL1B CASP1 19063908 2030119 Furthermore , caspase-1 , a promoter of IL-1beta production , was activated by treatment with alendronate , and inhibitor *reduced* the production of [IL-1beta] induced by alendronate and P. gingivalis . Positive_regulation IL1B CASP1 19105226 2086169 We hypothesized that metal implant debris can activate the inflammasome pathway in macrophages that causes *induced* cleavage of intracellular [pro-IL-1beta] into its mature form , resulting in IL-1beta secretion and induction of a broader proinflammatory response . Positive_regulation IL1B CASP1 19299628 2064136 Mitochondrial membrane potential , release of apoptogenic mitochondrial factors , [pro-IL-1beta] processing , and *activation* of and -3 were evaluated . Positive_regulation IL1B CASP1 19299628 2064138 Methazolamide and melatonin inhibit oxygen/glucose deprivation induced cell death , loss of mitochondrial membrane potential , release of mitochondrial factors , [pro-IL-1beta] processing , and *activation* of and -3 in primary cerebrocortical neurons . Positive_regulation IL1B CASP1 19454352 2084485 The known fungal pattern recognition receptors TLR2 and Dectin-1 regulate IL-1beta gene transcription , whereas the NLRP3 containing proinflammatory multiprotein complex , the NLRP3 inflammasome , controls *mediated* cleavage of [pro-IL-1beta] . Positive_regulation IL1B CASP1 19454703 2084565 In direct correlation with the increased viral internalization , antiviral Abs amplified the innate immune response to adenovirus as determined by the expression of NF-kappaB dependent genes , type I IFNs , and *dependent* [IL-1beta] maturation . Positive_regulation IL1B CASP1 19717510 2133533 In this study , we show that the ability of Staphylococcus aureus , a leading cause of infection in humans , to activate and *induce* [IL-1beta] secretion resides in culture supernatants of growing bacteria . Positive_regulation IL1B CASP1 19737897 2186518 Bacillus anthracis capsule activates and *induces* [interleukin-1beta] release from differentiated THP-1 and human monocyte derived dendritic cells . Positive_regulation IL1B CASP1 19833722 2169975 Rab39a binds and is *required* for caspase-1 dependent [interleukin-1beta] secretion . Positive_regulation IL1B CASP1 19997504 2174727 However , was *required* for secretion of the inflammatory cytokine [IL-1beta] in response to T3SS positive Y. pseudotuberculosis . Positive_regulation IL1B CASP1 20008285 2191233 RNA interference and inhibitor experiments in human PBMCs as well as experiments in Nlrp3 and Rip2 knockout bone marrow derived macrophages demonstrated that the Listeria induced [IL-1beta] release was *dependent* on ASC , , and NLRP3 , whereas NOD2 , Rip2 , NLRP1 , NLRP6 , NLRP12 , NLRC4 , and AIM2 appeared to be dispensable . Positive_regulation IL1B CASP1 20038581 2211132 The spontaneous secretion of [IL-1beta] from melanoma cells was *reduced* by inhibition of or the use of small interfering RNA directed against ASC . Positive_regulation IL1B CASP1 20477603 1506554 [IL-1beta] and IL-18 are closely related , and both *require* the intracellular cysteine protease for biologic activity . Positive_regulation IL1B CASP1 20588114 2285742 is *required* for [IL-1beta] activity and the release of free fatty acids from the adipocyte . Positive_regulation IL1B CASP1 21178113 2391032 Burkholderia cenocepacia O polysaccharide chain contributes to *dependent* [IL-1beta] production in macrophages . Positive_regulation IL1B CASP1 22198227 2518890 Activated *leads* to the secretion of proinflammatory cytokines , including [IL-1b] and IL-18 , and the promotion of pyroptosis , a form of phagocyte cell death induced by bacterial pathogens , in an inflamed tissue . Positive_regulation IL1B CASP1 24312444 2877978 Whereas caspase-1 activation is independent of caspase-11 in the canonical pathway of inflammasome activation , caspase-11 was found to trigger *dependent* [IL-1b] and IL-18 in response to non-canonical inflammasome activators . Positive_regulation IL1B CASP1 8228247 235725 Conversely , the inhibitor , Ac-Tyr-Val-Ala-Asp-CHO ( L-709,049 ) and the anti-inflammatory agent [ 5- ( 4-pyridyl ) 6 ( 4-fluorophenyl ) -2,3-dihydroimidazo ( 2,1-b ) thiazole ] ( SK & F 86002 ) *inhibited* [IL-1 beta] release in both the standard and staged release assays with IC50 of 1 microM . Positive_regulation IL1B CASP1 8541550 338739 The inhibitor *suppressed* OCI/AML3 growth in a dose dependent manner ( at 0.4 to 4 mumol/L ) and downregulated mature [IL-1 beta] production , as assessed by Western immunoblotting . Positive_regulation IL1B CASP1 9009343 410976 In double labeling experiments , we show that IpaB and ICE colocalize in the cytoplasm of the macrophage , suggesting that soon after secretion , IpaB binds to to initiate apoptosis and to *promote* the cleavage of [IL-1 beta] . Positive_regulation IL1B CASP1 9086432 421541 It was therefore hypothesized that may either *augment* the production of mature [IL-1 beta] and stimulate the proliferation of cells , in which IL-1 beta acts as an autocrine growth factor , or induce apoptosis . Positive_regulation IL1B CASP1 9086432 421542 Because IL-1 beta serves as either an autocrine or paracrine growth factor in AML , we recently investigated the effect of ICE inhibition on AML colony growth and found that inhibition *reduced* the production of mature [IL-1 beta] and suppressed AML progenitor proliferation . Positive_regulation IL1B CASP1 9121587 423879 A selective inhibitor *blocks* both lipopolysaccharide induced [IL-1beta] and IFN-gamma production from human mononuclear cells . Positive_regulation IL1B CASP1 9235962 445557 We report here that stimulation of human vascular SMC and endothelial cells ( EC ) through CD40 ligand , a mediator recently localized in human atheroma , induced elaboration of the [IL-1beta] precursor as well as *activation* of cell associated . Positive_regulation IL1B CASP1 9384684 408091 We found that inhibition of *reduced* the production of mature [IL-1 beta] and suppressed the proliferation of AML colony forming units , confirming the central role of IL-1 beta in AML progenitor proliferation . Positive_regulation IL1B CASP1 9427712 481726 Taken together , these results show that LPS moderately activates caspase-1 and that activation *contributes* to LPS induction of [IL-1 beta] secretion . Positive_regulation IL1B CASP1 9670975 519741 The *dependent* activation of [IL-1 beta] may represent a common autocrine pathway for the divergent stimuli that inhibit the constitutive expression of neutrophil programmed cell death during inflammation . Positive_regulation IL1B CASP1 9756994 535901 However , the pattern of mRNA expression is consistent with a requirement for *mediated* [IL-1beta] production in chicken immune tissues . Positive_regulation IL1B CASP10 11028539 739355 Inhibition of activity by Z-VAD significantly *reduced* lipopolysaccharide (LPS) and Staphylococcus aureus ( SAC ) induced release of mature [IL-1beta] in septic patients and controls . Positive_regulation IL1B CASP10 16305880 1485996 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , [interleukin-1beta] and interleukin-6 , and *activation* of caspase-1 , caspase-3 and . Positive_regulation IL1B CASP10 19454703 2084566 In direct correlation with the increased viral internalization , antiviral Abs amplified the innate immune response to adenovirus as determined by the expression of NF-kappaB dependent genes , type I IFNs , and *dependent* [IL-1beta] maturation . Positive_regulation IL1B CASP12 11028539 739365 Inhibition of activity by Z-VAD significantly *reduced* lipopolysaccharide (LPS) and Staphylococcus aureus ( SAC ) induced release of mature [IL-1beta] in septic patients and controls . Positive_regulation IL1B CASP12 16305880 1486006 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , [interleukin-1beta] and interleukin-6 , and *activation* of caspase-1 , caspase-3 and . Positive_regulation IL1B CASP12 19454703 2084576 In direct correlation with the increased viral internalization , antiviral Abs amplified the innate immune response to adenovirus as determined by the expression of NF-kappaB dependent genes , type I IFNs , and *dependent* [IL-1beta] maturation . Positive_regulation IL1B CASP14 11028539 739356 Inhibition of activity by Z-VAD significantly *reduced* lipopolysaccharide (LPS) and Staphylococcus aureus ( SAC ) induced release of mature [IL-1beta] in septic patients and controls . Positive_regulation IL1B CASP14 16305880 1485997 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , [interleukin-1beta] and interleukin-6 , and *activation* of caspase-1 , caspase-3 and . Positive_regulation IL1B CASP14 19454703 2084567 In direct correlation with the increased viral internalization , antiviral Abs amplified the innate immune response to adenovirus as determined by the expression of NF-kappaB dependent genes , type I IFNs , and *dependent* [IL-1beta] maturation . Positive_regulation IL1B CASP16 11028539 739366 Inhibition of activity by Z-VAD significantly *reduced* lipopolysaccharide (LPS) and Staphylococcus aureus ( SAC ) induced release of mature [IL-1beta] in septic patients and controls . Positive_regulation IL1B CASP16 16305880 1486007 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , [interleukin-1beta] and interleukin-6 , and *activation* of caspase-1 , caspase-3 and . Positive_regulation IL1B CASP16 19454703 2084577 In direct correlation with the increased viral internalization , antiviral Abs amplified the innate immune response to adenovirus as determined by the expression of NF-kappaB dependent genes , type I IFNs , and *dependent* [IL-1beta] maturation . Positive_regulation IL1B CASP2 11028539 739357 Inhibition of activity by Z-VAD significantly *reduced* lipopolysaccharide (LPS) and Staphylococcus aureus ( SAC ) induced release of mature [IL-1beta] in septic patients and controls . Positive_regulation IL1B CASP2 16305880 1485998 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , [interleukin-1beta] and interleukin-6 , and *activation* of caspase-1 , caspase-3 and . Positive_regulation IL1B CASP2 19454703 2084568 In direct correlation with the increased viral internalization , antiviral Abs amplified the innate immune response to adenovirus as determined by the expression of NF-kappaB dependent genes , type I IFNs , and *dependent* [IL-1beta] maturation . Positive_regulation IL1B CASP3 11028539 739358 Inhibition of activity by Z-VAD significantly *reduced* lipopolysaccharide (LPS) and Staphylococcus aureus ( SAC ) induced release of mature [IL-1beta] in septic patients and controls . Positive_regulation IL1B CASP3 12540519 1050545 8. This study demonstrates that injection of a selective caspase-1 inhibitor after myocardial ischaemia markedly reduced the detrimental effect conferred by hypercholesterolaemia on myocardial ischaemia-reperfusion injury by attenuating both necrotic as well as apoptotic cell death pathways through inhibition of [IL-1beta] production and *activation* of caspase-1 and . Positive_regulation IL1B CASP3 16153910 1455399 The kidney was analyzed for expression of tumor necrosis factor alpha , [interleukin 1beta] , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 mitogen activated protein kinase , , and caspase 8 ( Western blot ) . Positive_regulation IL1B CASP3 16305880 1485999 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , [interleukin-1beta] and interleukin-6 , and *activation* of caspase-1 , caspase-3 and . Positive_regulation IL1B CASP3 16310170 1502952 The permeable exogenous C ( 2 ) -ceramide reproduces [IL-1beta effects on: (i)] inhibition of adenylyl cyclase activity , ( ii ) down-regulation of ERK1/2 phosphorylation , ( iii ) *activation* of , and ( iv ) apoptosis in pig thyroid cells . Positive_regulation IL1B CASP3 19299628 2064137 Mitochondrial membrane potential , release of apoptogenic mitochondrial factors , [pro-IL-1beta] processing , and *activation* of were evaluated . Positive_regulation IL1B CASP3 19299628 2064139 Methazolamide and melatonin inhibit oxygen/glucose deprivation induced cell death , loss of mitochondrial membrane potential , release of mitochondrial factors , [pro-IL-1beta] processing , and *activation* of in primary cerebrocortical neurons . Positive_regulation IL1B CASP3 19454703 2084569 In direct correlation with the increased viral internalization , antiviral Abs amplified the innate immune response to adenovirus as determined by the expression of NF-kappaB dependent genes , type I IFNs , and *dependent* [IL-1beta] maturation . Positive_regulation IL1B CASP3 19996917 2185061 Myocardial [IL-1beta] and TNF-alpha production and *activation* of were significantly decreased after infusion of both cell groups . Positive_regulation IL1B CASP4 11028539 739359 Inhibition of activity by Z-VAD significantly *reduced* lipopolysaccharide (LPS) and Staphylococcus aureus ( SAC ) induced release of mature [IL-1beta] in septic patients and controls . Positive_regulation IL1B CASP4 16305880 1486000 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , [interleukin-1beta] and interleukin-6 , and *activation* of caspase-1 , caspase-3 and . Positive_regulation IL1B CASP4 19454703 2084570 In direct correlation with the increased viral internalization , antiviral Abs amplified the innate immune response to adenovirus as determined by the expression of NF-kappaB dependent genes , type I IFNs , and *dependent* [IL-1beta] maturation . Positive_regulation IL1B CASP5 11028539 739360 Inhibition of activity by Z-VAD significantly *reduced* lipopolysaccharide (LPS) and Staphylococcus aureus ( SAC ) induced release of mature [IL-1beta] in septic patients and controls . Positive_regulation IL1B CASP5 16305880 1486001 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , [interleukin-1beta] and interleukin-6 , and *activation* of caspase-1 , caspase-3 and . Positive_regulation IL1B CASP5 19454703 2084571 In direct correlation with the increased viral internalization , antiviral Abs amplified the innate immune response to adenovirus as determined by the expression of NF-kappaB dependent genes , type I IFNs , and *dependent* [IL-1beta] maturation . Positive_regulation IL1B CASP6 11028539 739361 Inhibition of activity by Z-VAD significantly *reduced* lipopolysaccharide (LPS) and Staphylococcus aureus ( SAC ) induced release of mature [IL-1beta] in septic patients and controls . Positive_regulation IL1B CASP6 16305880 1486002 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , [interleukin-1beta] and interleukin-6 , and *activation* of caspase-1 , caspase-3 and . Positive_regulation IL1B CASP6 19454703 2084572 In direct correlation with the increased viral internalization , antiviral Abs amplified the innate immune response to adenovirus as determined by the expression of NF-kappaB dependent genes , type I IFNs , and *dependent* [IL-1beta] maturation . Positive_regulation IL1B CASP7 11028539 739362 Inhibition of activity by Z-VAD significantly *reduced* lipopolysaccharide (LPS) and Staphylococcus aureus ( SAC ) induced release of mature [IL-1beta] in septic patients and controls . Positive_regulation IL1B CASP7 16305880 1486003 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , [interleukin-1beta] and interleukin-6 , and *activation* of caspase-1 , caspase-3 and . Positive_regulation IL1B CASP7 19454703 2084573 In direct correlation with the increased viral internalization , antiviral Abs amplified the innate immune response to adenovirus as determined by the expression of NF-kappaB dependent genes , type I IFNs , and *dependent* [IL-1beta] maturation . Positive_regulation IL1B CASP8 11028539 739363 Inhibition of activity by Z-VAD significantly *reduced* lipopolysaccharide (LPS) and Staphylococcus aureus ( SAC ) induced release of mature [IL-1beta] in septic patients and controls . Positive_regulation IL1B CASP8 16153910 1455400 The kidney was analyzed for expression of tumor necrosis factor alpha , [interleukin 1beta] , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 mitogen activated protein kinase , caspase 3 , and ( Western blot ) . Positive_regulation IL1B CASP8 16305880 1486004 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , [interleukin-1beta] and interleukin-6 , and *activation* of caspase-1 , caspase-3 and . Positive_regulation IL1B CASP8 18054255 1918834 Western blot studies indicated that [IL-1beta+Ro] did not *induce* the time dependent activation of , -7 and -3 as seen with TNF-alpha+Ro . Positive_regulation IL1B CASP8 19454703 2084574 In direct correlation with the increased viral internalization , antiviral Abs amplified the innate immune response to adenovirus as determined by the expression of NF-kappaB dependent genes , type I IFNs , and *dependent* [IL-1beta] maturation . Positive_regulation IL1B CASP9 11028539 739364 Inhibition of activity by Z-VAD significantly *reduced* lipopolysaccharide (LPS) and Staphylococcus aureus ( SAC ) induced release of mature [IL-1beta] in septic patients and controls . Positive_regulation IL1B CASP9 16305880 1486005 Myocardial tissue was then assessed for products of p38 MAPK activation , expression of tumor necrosis factor , [interleukin-1beta] and interleukin-6 , and *activation* of caspase-1 , caspase-3 and . Positive_regulation IL1B CASP9 19454703 2084575 In direct correlation with the increased viral internalization , antiviral Abs amplified the innate immune response to adenovirus as determined by the expression of NF-kappaB dependent genes , type I IFNs , and *dependent* [IL-1beta] maturation . Positive_regulation IL1B CAT 10195945 604251 Although AT decreased superoxide release from activated monocytes , superoxide dismutase and *had* no effect on [IL-1 beta] release . Positive_regulation IL1B CCL1 9079810 420760 Thus , neutralization of endogenous IL-1alpha using an anti-IL-1alpha antiserum inhibits the induction of I-309 transcripts in response to stimulation with immobilized IgG and LPS , and exogenous IL-1alpha or [IL-1beta] *induces* transcripts in monocytes stimulated with immobilized IgG . Positive_regulation IL1B CCL11 19494504 2091691 *induced* production of [IL-1beta] , IL-6 , and MIP-1beta was significantly reduced by the MEK inhibitor PD98059 , p38 MAPK inhibitor SB203580 , or PI3K inhibitor LY294002 . Positive_regulation IL1B CCL13 10934112 720414 In support of our in situ findings demonstrating MCP-4 expression in epithelial cells and mononuclear cells in vivo , we have found that expression can be *induced* in these cells in vitro by tumor necrosis factor-alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] . Positive_regulation IL1B CCL17 20022349 2241204 In this study , we investigated whether and CCL28 transcription in cultured keratinocytes is *induced* by TNF-alpha , [IL-1beta] , or IFN-gamma . Positive_regulation IL1B CCL2 10372996 622134 [IL-1beta] and TNF-alpha *induced* dose dependent increases in HRPE IL-8 and secretion with maximal stimulation observed at 2-5 ng/ml . IL-4 alone ( 100 ng/ml ) resulted in a slight increase of MCP-1 and IL-8 secretion . Positive_regulation IL1B CCL2 10413089 630925 In human vascular endothelial cells , [interleukin-1beta] and tumor necrosis factor-alpha *induced* endogenous protein secretion , mRNA expression and promoter activity . Positive_regulation IL1B CCL2 10540157 563257 In contrast , [IL-1beta] strongly *induced* secretion preferentially into the basal compartment of all RPE monolayers tested . Positive_regulation IL1B CCL2 10580798 570121 However , 100 u/ml [IL-1beta] *induced* greater stimulation of both IL-8 and secretion in HCEC ( 50 and 20 times above controls , respectively ) than in FHAS ( three and two times above controls , respectively ) . Positive_regulation IL1B CCL2 10741905 680026 Both IL-1alpha and [IL-1beta] *induced* ICAM-1 expression and IL-8 and production at lower doses than TNF alpha or TNF beta . Positive_regulation IL1B CCL2 10889171 710419 IL-8 and secretion was rapidly *induced* by both [IL-1beta] and tumor necrosis factor (TNF)-alpha . Positive_regulation IL1B CCL2 11317664 806663 [Interleukin-1 beta] *induced* mRNA expression in rat beta cells , with a maximum induction after 6 h . Positive_regulation IL1B CCL2 11317664 806665 [IL-1 beta] *induced* both MCP-1 mRNA expression and a threefold increase in medium protein accumulation in human islet cells . Positive_regulation IL1B CCL2 11886171 919896 We found that the serum content of inflammatory cytokines IL-8 , [IL-1beta] , TNF-alpha and ( MCP-1 ) are *increased* during AP. Injection of IT9302 or mon . IL-8 antibody , diminish the concentration of these cytokines in the serum , with the exception that mon . IL-8 antibody actually increased the circulating level of MCP-1 . Positive_regulation IL1B CCL2 11989790 936374 [IL-1 beta] *induced* the maximum release of IL-8 ( 800-fold ) and ( 164-fold ) , as compared to the controls . Positive_regulation IL1B CCL2 12569227 1057238 Plasma interleukin (IL)-6 , IL-8 , IL-10 , granulocyte colony stimulating factor ( G-CSF ) , macrophage CSF (M-CSF) , and increased significantly after the race , and urine [IL-1beta] , IL-6 , G-CSF , M-CSF , and MCP-1 *increased* significantly . Positive_regulation IL1B CCL2 15361371 1293702 Sulprostone , an EP(1)/EP(3) agonist , had no effect on [IL1beta] *induced* expression . Positive_regulation IL1B CCL2 17015748 1629889 [IL-1beta] *induced* increased mRNA levels of MIP-2 , , RANTES , inducible NO synthase (iNOS) , and cyclooxygenase-2 (COX-2) in the IEC-18 cell line . Positive_regulation IL1B CCL2 19002429 2022193 [IL-1beta] *induced* a time dependent increase in and Mip-2 ( also known as Cxcl2 ) mRNA expression after 6 h of stimulation in insulinoma (INS)-1 and neonatal rat islet cells . Positive_regulation IL1B CCL2 19117935 2060756 [IL-1beta] also *induced* , IL-6 , and IL-8 more vigorously in TAO derived fibroblasts . Positive_regulation IL1B CCL2 20478455 2263041 [IL-1beta] and IL-6 simultaneously *induced* IL-8 and secretion in PDL cells , whereas SOCS-3 overexpression suppressed secretion of these chemokines through inhibition of phosphorylation in downstream signaling . Positive_regulation IL1B CCL2 21544387 407753 We compared the in vitro effects of various cytokines on the expression of monocyte chemoattractant protein-1 ( MCP-1 ) in glioma cell lines and found that expression was highly *induced* by tumor necrosis factor-alpha (TNF alpha) and [interleukin-1 beta] . Positive_regulation IL1B CCL2 7942160 276335 At the mRNA level , [IL-1 beta] and TNF-alpha strongly *induced* expression ; Positive_regulation IL1B CCL2 9610617 508782 [IL-1beta] *induced* , CINC , RANTES and ICAM-1 gene expression in a time dependent manner . Positive_regulation IL1B CCL2 9657919 516882 [IL-1beta] and TNF-alpha synergistically *induced* IL-6 and GM-CSF and additively induced IL-8 and production , while IL-2 , IL-10 , IFN-alpha , and IFN-gamma had little or no additional effects . Positive_regulation IL1B CCL20 19428685 2077102 In turn , *stimulated* [IL-1beta] and inducible nitric oxide synthase expressions in rat microglia and rat brains . Positive_regulation IL1B CCL23 9187369 437041 mRNA transcripts were *induced* in monocytes by [IL-1beta] and , to a lesser extent , by IFNgamma , and were detected in RNA extracted from normal human liver and gastrointestinal tract . Positive_regulation IL1B CCL26 20059579 2241574 Tumour necrosis factor-alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] alone did not *induce* expression , yet these pro-inflammatory cytokines synergized with IL-4 to increase CCL26 protein expression . Positive_regulation IL1B CCL28 16581045 1496455 [IL-1beta] and TNF-alpha *induce* increased expression of by airway epithelial cells via an NFkappaB dependent pathway . Positive_regulation IL1B CCL28 20022349 2241205 In this study , we investigated whether CCL17 and transcription in cultured keratinocytes is *induced* by TNF-alpha , [IL-1beta] , or IFN-gamma . Positive_regulation IL1B CCL3 17668983 1776973 expression in PMNs and gingival epithelial cells was *induced* by [IL-1beta] and LPS , but neither induced MIP-1alpha expression in gingival fibroblasts or osteoblastic cells . Positive_regulation IL1B CCL4L2 14746807 1182109 [Interleukin-1beta] *induces* expression in human hepatocytes . Positive_regulation IL1B CCL5 15749911 1379788 We now show , using real-time PCR , that in astrocytes [IL-1beta] *induces* the expression of IFN-beta , IRF7 , CXCL10/IFN-gamma-inducible protein-10 , and . Positive_regulation IL1B CCL8 19224633 2044675 chemokine ligand 8 (CCL8) was *induced* at only suboptimal levels in fibroblasts and endothelial cells by [IL-1beta] or IFN-gamma , unless these cytokines were combined . Positive_regulation IL1B CCR6 18698005 1973933 In the *presence* of compared with CXCR3+ Th cells , monocytes/macrophages produced much higher levels of matrix metalloproteinase-1 , -3 , and -9 but similar levels of CXCL10 and [IL-1beta] . Positive_regulation IL1B CD14 19010986 2029051 IL-6 , [IL-1beta] and cigarette smoke condensate *induced* the expression of LBP and by airway epithelial cells . Positive_regulation IL1B CD14 9369942 464081 These observations suggest a functional *role* of endogenous in LPS stimulated expression of the [IL-1 beta] gene in the cells . Positive_regulation IL1B CD14 9525321 494622 Recombinant murine [interleukin-1beta (IL-1beta)] *induced* a transient increase in plasma levels of with a peak at 8 h , and this increase in plasma CD14 antigen was accompanied by increased levels of CD14 messenger ribonucleic acid ( mRNA ) in all organs examined . Positive_regulation IL1B CD160 18976941 2113869 In addition , our data show that peripheral receptors *mediate* the production of both TNFalpha and [IL-1beta] in the TMJ as well as some of the inflammatory signs , such as plasma extravasation and leukocyte influx , but not the nociceptive component . Positive_regulation IL1B CD28 10928971 719642 FK506 inhibited *induced* TNF-alpha and [IL-1beta] production at concentrations less than 1 ng ml(-1) . Positive_regulation IL1B CD28 15597149 1346493 LEF inhibited *induced* production of TNF-alpha , [IL-1beta] and IL-6 , with IC50 values of 27 , 21 and 21 microg/ml , respectively . Positive_regulation IL1B CD4 19161420 2007015 IL-23 , IL-6 , transforming growth factor ( TGF-beta1 ) , and [IL-1beta] in supernatants from activated human DCs *induce* human naive ( + ) T cells to produce IL-17 . Positive_regulation IL1B CD4 19359475 2074543 These results indicate that [IL-1beta] signaling in T cells markedly *induces* robust and durable primary and secondary responses . Positive_regulation IL1B CD40 10026206 591305 Together , the data demonstrate that mediated *induction* of [IL-1beta] and tumor necrosis factor-alpha synthesis is dependent on a MEK/ERK pathway which is obstructed by signals generated through the action of IL-4 and IL-10 . Positive_regulation IL1B CD40 10535333 562762 Furthermore , ligation of endothelial and simultaneous treatment of human endothelial cells with IFN-gamma or Abeta peptides *leads* to a significant release of [interleukin-1beta (IL-1beta)] , a marker for endothelial cell activation . Positive_regulation IL1B CD40 12039918 949559 IL-6 , IL-8 , tumor necrosis factor (TNF)-alpha , IL-12 and [IL-1 beta] were *induced* upon CD40 ligation and IFN-gamma stimulation , while IL-10 could be induced by ligation alone and was reduced again by the addition of IFN-gamma . Positive_regulation IL1B CD40 15240722 1270435 The production of TNF and [IL-1beta] was *induced* by membranes of stimulated T cells in the three types of target cells , whereas induced TNF production in IFN-gamma-macrophages only . Positive_regulation IL1B CD40 15240722 1270437 *induced* neither transcript nor protein of cytokines in monocytes , whereas in IFN-gamma-macrophages , [IL-1beta] and TNF mRNA were observed , but only TNF was measured in cell supernatants . Positive_regulation IL1B CD40 9218603 442279 Both IL-4 and IL-10 decreased *dependent* [IL-1beta] synthesis in a dose dependent manner individually and synergized in this effect when used concurrently , with minimal effect on CD40 surface expression . Positive_regulation IL1B CD40LG 10950771 723455 ELISA and cytofluorometric analysis demonstrated that stimulation of HIV-1 infected macrophages *resulted* in substantial production of [IL-1beta] and IL-6 . Positive_regulation IL1B CD40LG 11160202 781495 On the other hand , ATP markedly and dose-dependently inhibited LPS- and soluble *dependent* production of IL-1alpha , [IL-1beta] , TNF-alpha , IL-6 , and IL-12 , whereas IL-1 receptor antagonist and IL-10 production was not affected . Positive_regulation IL1B CD40LG 12884872 1116612 When added to GM-CSF , IL-4 and TGF-beta1 containing-cultures , LPS or [IL-1beta] also *induced* significant numbers of Langerin+CD83- immature cells displaying a low allostimulatory activity , while largely promoted highly allostimulatory Langerin-CD83+ cells . Positive_regulation IL1B CD44 14872494 1208465 The action of HA on [IL-1beta] may *involve* direct interaction between HA and on chondrocytes . Positive_regulation IL1B CD44 16219515 1469085 It is concluded from the present study that human cervical mRNA expression is *induced* by [interleukin-1beta] . Positive_regulation IL1B CD46 16249450 1471737 Expression of the NF-kappaB dependent genes IkappaB-alpha and was *induced* in human islets by [IL-1beta] but not by high glucose . Positive_regulation IL1B CD58 8525920 326447 In preliminary experiments with fluorescence microscopy we found that neither TNF-alpha nor [IL-1 beta] *induce* in the same fashion as IFN-gamma . Positive_regulation IL1B CD69 8660807 365002 These results indicate that CD2 is required for T cell induction of IL-1 beta mRNA through interaction with LFA-3 on the monocyte and that the generation of soluble [IL-1 beta] is *regulated* by . Positive_regulation IL1B CD79A 15932509 1414632 On the other hand , we also found an IgA induced pro-inflammatory activity , namely *mediated* up-regulation of the release of pro-inflammatory [IL-1beta] as well as down-regulation of the anti-inflammatory cytokines IL-10 and IL-12p40 from LPS stimulated monocytes and PBMC and a down-regulation of transforming growth factor (TGF)-beta from resting and LPS stimulated PBMC . Positive_regulation IL1B CD79A 8262556 239181 Both and IgG immune complexes also *increased* monocyte [interleukin-1 beta (IL-1 beta)] production . Positive_regulation IL1B CD86 18761792 1956703 Chemical sensitizer DNCB could induce the high expression of on DC membrane , and NiSO4 and HCA could *induce* DC to release [IL-1 beta] and IL-6 . Positive_regulation IL1B CD8A 10845914 700714 Interleukin-1beta converting enzyme ( ICE ) inhibitors do not prevent the recovery of IL-1beta bioactivity after allorecognition , indicating that allospecific ( + ) T cells may *induce* the release of bioactive [IL-1beta] via mechanism ( s ) other than ICE activation . Positive_regulation IL1B CD8B 10845914 700715 Interleukin-1beta converting enzyme ( ICE ) inhibitors do not prevent the recovery of IL-1beta bioactivity after allorecognition , indicating that allospecific ( + ) T cells may *induce* the release of bioactive [IL-1beta] via mechanism ( s ) other than ICE activation . Positive_regulation IL1B CDC123 19675207 2150736 These results further elucidate a mechanism of *induced* [IL-1beta] release and suggest a novel , immune evasion strategy in which IL-1beta containing macrophages might release primarily inactive cytokine following exposure to high doses of these toxins . Positive_regulation IL1B CDC16 19675207 2150737 These results further elucidate a mechanism of *induced* [IL-1beta] release and suggest a novel , immune evasion strategy in which IL-1beta containing macrophages might release primarily inactive cytokine following exposure to high doses of these toxins . Positive_regulation IL1B CDC20 19675207 2150738 These results further elucidate a mechanism of *induced* [IL-1beta] release and suggest a novel , immune evasion strategy in which IL-1beta containing macrophages might release primarily inactive cytokine following exposure to high doses of these toxins . Positive_regulation IL1B CDC23 19675207 2150739 These results further elucidate a mechanism of *induced* [IL-1beta] release and suggest a novel , immune evasion strategy in which IL-1beta containing macrophages might release primarily inactive cytokine following exposure to high doses of these toxins . Positive_regulation IL1B CDC26 19675207 2150748 These results further elucidate a mechanism of *induced* [IL-1beta] release and suggest a novel , immune evasion strategy in which IL-1beta containing macrophages might release primarily inactive cytokine following exposure to high doses of these toxins . Positive_regulation IL1B CDC27 19675207 2150740 These results further elucidate a mechanism of *induced* [IL-1beta] release and suggest a novel , immune evasion strategy in which IL-1beta containing macrophages might release primarily inactive cytokine following exposure to high doses of these toxins . Positive_regulation IL1B CDC34 19675207 2150741 These results further elucidate a mechanism of *induced* [IL-1beta] release and suggest a novel , immune evasion strategy in which IL-1beta containing macrophages might release primarily inactive cytokine following exposure to high doses of these toxins . Positive_regulation IL1B CDC37 19675207 2150742 These results further elucidate a mechanism of *induced* [IL-1beta] release and suggest a novel , immune evasion strategy in which IL-1beta containing macrophages might release primarily inactive cytokine following exposure to high doses of these toxins . Positive_regulation IL1B CDC40 19675207 2150743 These results further elucidate a mechanism of *induced* [IL-1beta] release and suggest a novel , immune evasion strategy in which IL-1beta containing macrophages might release primarily inactive cytokine following exposure to high doses of these toxins . Positive_regulation IL1B CDC42 19675207 2150744 These results further elucidate a mechanism of *induced* [IL-1beta] release and suggest a novel , immune evasion strategy in which IL-1beta containing macrophages might release primarily inactive cytokine following exposure to high doses of these toxins . Positive_regulation IL1B CDC45 19675207 2150745 These results further elucidate a mechanism of *induced* [IL-1beta] release and suggest a novel , immune evasion strategy in which IL-1beta containing macrophages might release primarily inactive cytokine following exposure to high doses of these toxins . Positive_regulation IL1B CDC6 19675207 2150746 These results further elucidate a mechanism of *induced* [IL-1beta] release and suggest a novel , immune evasion strategy in which IL-1beta containing macrophages might release primarily inactive cytokine following exposure to high doses of these toxins . Positive_regulation IL1B CDC7 19675207 2150747 These results further elucidate a mechanism of *induced* [IL-1beta] release and suggest a novel , immune evasion strategy in which IL-1beta containing macrophages might release primarily inactive cytokine following exposure to high doses of these toxins . Positive_regulation IL1B CDC73 10447739 577419 We conclude that CRH and can *induce* the expression of [IL-1beta] , but this is not obligatory for increased PGE2 release , and the effect of these stimuli on COX-2 expression is a direct , IL-1beta independent effect . Positive_regulation IL1B CDC73 16025141 1453420 TNF-alpha was necessary for the local *induced* [IL-1beta] production . Positive_regulation IL1B CDC73 16439466 1554558 H ( 2 ) O ( 2 ) causes formation of [IL-1beta] that may *induce* production of in the muscle , possibly closing a self sustaining cycle of production of inflammatory mediators . Positive_regulation IL1B CDC73 16829183 1591459 Both TNF-alpha and [IL-1beta] induced HUVEC platelet activating factor (PAF) production and was *required* for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine ) . Positive_regulation IL1B CDC73 1710753 158263 , alone and in combination with endotoxin , *caused* an increase in mRNA levels for [IL-1 beta] . Positive_regulation IL1B CDC73 19675207 2150735 These results further elucidate a mechanism of *induced* [IL-1beta] release and suggest a novel , immune evasion strategy in which IL-1beta containing macrophages might release primarily inactive cytokine following exposure to high doses of these toxins . Positive_regulation IL1B CDC73 8080039 270827 [Interleukin-1 beta] and tumor necrosis factor-alpha *induce* production by endothelium , and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist . Positive_regulation IL1B CDKN1A 15187102 1256324 [IL-1beta] *induces* ( Cip1/Waf1 ) , which may contribute to its inhibition of IGF-I activated Cdk2 . Positive_regulation IL1B CDKN1A 17454300 1730135 Overexpression of *blocked* [IL-1beta-] or CDK6 induced suppression of type II collagen expression . Positive_regulation IL1B CEBPA 14766209 1207531 In addition , forced expression of C/EBPbeta could mimic the IL-1beta effect on the promoter activity , but subsequent mutation analysis of the C/EBP binding sites indicated that direct binding to the promoter is not *required* for the [IL-1beta] response . Positive_regulation IL1B CEBPA 9134219 427384 Moreover , staurosporine significantly augmented the *activation* of by [IL-1 beta] and forskolin . Positive_regulation IL1B CEBPB 10594926 655134 Here we show that lipopolysaccharides (LPS) , [IL-1beta] , and TNFalpha *induce* the expression of the and -delta genes in mouse primary astrocytes . Positive_regulation IL1B CEBPB 11035101 741058 These findings suggest that [IL-1beta] induces nuclear translocation of p50 containing dimers and that p50 interacts with *activated* by both IL-6 and IL-1beta to induce CRP expression . Positive_regulation IL1B CEBPB 11474579 841782 ( LAP and LIP isoforms ) was constitutively present in PVEC and was *induced* ( approximately 2-fold ) by [IL-1beta] , whereas C/EBPdelta was not constitutively expressed but was strongly induced by IL-1beta . Positive_regulation IL1B CEBPB 15383601 1298977 Because [IL-1beta] can *induce* expression , the role of C/EBPbeta isoforms in IL-1beta regulation of alpha-SMA gene expression was investigated in rat lung myofibroblasts . Positive_regulation IL1B CEBPB 16453302 1540711 [Interleukin-1 beta] induction of matrix metalloproteinase-1 transcription in chondrocytes *requires* ERK dependent activation of . Positive_regulation IL1B CEBPB 16453302 1540719 Here we show that [IL-1beta] stimulation of chondrocytes *induced* phosphorylation of on threonine 235 , and that the ERK pathway inhibitor PD98059 reduced this phosphorylation . Positive_regulation IL1B CEBPB 8207231 261393 These data are consistent with the *requirement* for ( NFIL-6 ) and C/EBP delta ( NFIL-6 beta ) in the activation of murine [IL-1 beta] gene expression by endotoxin . Positive_regulation IL1B CEBPD 11474579 841783 C/EBPbeta ( LAP and LIP isoforms ) was constitutively present in PVEC and was *induced* ( approximately 2-fold ) by [IL-1beta] , whereas was not constitutively expressed but was strongly induced by IL-1beta . Positive_regulation IL1B CEBPD 8207231 261394 These data are consistent with the *requirement* for C/EBP beta ( NFIL-6 ) and ( NFIL-6 beta ) in the activation of murine [IL-1 beta] gene expression by endotoxin . Positive_regulation IL1B CFD 15518718 1328728 Primary cultures of rat hepatocytes were treated with [IL-1beta] in the *presence* and absence of . Positive_regulation IL1B CFL1 15467300 1335174 These novel observations in PASMCs indicate that LIMK2 and expression can be *induced* by PDGF or [IL-1beta] . Positive_regulation IL1B CFL2 15467300 1335175 These novel observations in PASMCs indicate that LIMK2 and expression can be *induced* by PDGF or [IL-1beta] . Positive_regulation IL1B CGA 1572315 187224 These observations along with the demonstration of the *dependent* preovulatory induction of ovarian [IL-1 beta] gene expression provide strong support for the view that IL-1 may be the centerpiece of an intraovarian regulatory loop concerned with the promotion of the preovulatory cascade . Positive_regulation IL1B CGB8 1572315 187223 These observations along with the demonstration of the dependent preovulatory *induction* of ovarian [IL-1 beta] gene expression provide strong support for the view that IL-1 may be the centerpiece of an intraovarian regulatory loop concerned with the promotion of the preovulatory cascade . Positive_regulation IL1B CHGA 12948843 1136988 In the TNBS group , and PG-KII *increased* scores for the severity of colonic damage , stimulated the production of [IL-1beta] and increased granulocyte infiltration into the colon ( MPO activity ) . Positive_regulation IL1B CHUK 16286467 1509591 In the present report , we describe a mechanism whereby [interleukin-1beta (IL-1beta)] stimulation of NFkappaB is partially *regulated* by H2O2 mediated activation of NIK and subsequent NIK mediated phosphorylation of . Positive_regulation IL1B CISH 10969179 728341 In tonsillar cells , expression was increased and SOCS-2 was *induced* by [IL-1beta] , IL-6 , PRL and GH . Positive_regulation IL1B CISH 11014223 736330 Although [IL-1/beta] and TNFalpha alone *induced* only weakly the expression of SOCS-3 and , these cytokines strongly potentiated the induction of these two SOCS by GH . Positive_regulation IL1B CLEC7A 20421639 2262537 Moreover , receptor associated Syk tyrosine kinase was *essential* for beta-glucan induced [IL-1beta] mRNA expression . Positive_regulation IL1B CNR1 18393970 1958043 The immunosuppressive effect of AM404 on [IL-1beta] levels is *mediated* by the cannabinoid receptor . Positive_regulation IL1B CNTF 11771938 899295 RT-PCR analysis demonstrated that increased levels of FGF-2 and nerve growth factor (NGF) mRNA and that [IL-1beta] *increased* NGF and hepatocyte growth factor mRNA levels . Positive_regulation IL1B CNTF 9753298 533903 potentiated IL-1beta mediated NO synthesis from RIN-5AH cells by 83 % , and [IL-1beta] *induced* islet inducible NO-synthase (iNOS) mRNA expression fourfold . Positive_regulation IL1B COL2A1 16736518 1570650 Surface bound containing immune complexes *induce* production of tumor necrosis factor alpha , [interleukin-1beta] , and interleukin-8 from peripheral blood monocytes via Fc gamma receptor IIA : a potential pathophysiologic mechanism for humoral anti-type II collagen immunity in arthritis . Positive_regulation IL1B COL2A1 7622181 315728 In the other RA patients with lower SF monocyte count , *induced* significantly higher [IL-1 beta] than the medium control levels by SF MNC ( P < 0.01 ) or that of the other diseases ( P < 0.01 ) . Positive_regulation IL1B COP 11432859 850292 Our data indicate that can *regulate* [IL-1beta] secretion , implying that COP may play a role in down regulating inflammatory responses analogous to the CARD protein ICEBERG . Positive_regulation IL1B CPA1 8931762 397881 In the *presence* of LPS and , however , [IL-1 beta] and IL-6 mRNA levels gradually increased up to 24 h reaching 2.5 and 29-fold higher than controls , respectively . Positive_regulation IL1B CPB1 19923057 2166985 *resulted* in increased TNF-alpha and [IL-1beta] production in the lung tissues . Positive_regulation IL1B CPB2 19923057 2166986 *resulted* in increased TNF-alpha and [IL-1beta] production in the lung tissues . Positive_regulation IL1B CPOX 12031964 947866 Sodium salicylate also prevented IL-1beta from inducing EP3 and gene expression in islets and thereby *prevented* [IL-1beta] from inhibiting glucose induced insulin secretion . Positive_regulation IL1B CPOX 12881225 1157240 Whether the effects of IL-1beta were mediated through a prostaglandin pathway and whether [IL-1beta] *induced* the expression of was also examined . Positive_regulation IL1B CPOX 15111866 1241218 Our data suggest that [IL-1beta] is inhibitory and that this effect is *mediated* by . Positive_regulation IL1B CPOX 15862289 1400883 The inhibitors indomethacin and NS398 *inhibited* [IL-1beta] but not TGFbeta mediated VEGF-A production . Positive_regulation IL1B CPOX 9705828 526080 [IL-1 beta] *induced* ICAM-1 , and activity , while it had no affect on VCAM-1 . Positive_regulation IL1B CR2 10593868 572832 This induction of [IL-1beta] production was accompanied by increased steady-state levels of its mRNA in gp350 treated AMM , and was *dependent* on the specific binding of rgp350 to the EBV receptor . Positive_regulation IL1B CREB1 10397405 627822 This was demonstrated by showing that coexpression of stimulated native but not CRE mutant promoter and that [IL-1beta] and PMA *induced* less activity with the mutant promoter as compared to the native promoter . Positive_regulation IL1B CREB1 14999073 1216751 Using CREB antisense to determine the causal relationship between V1 agonist induced CREB activation and suppression of IL-1beta and TNF-alpha , we demonstrated that decreased [IL-1beta] and TNF-alpha gene expression was *dependent* on upstream activation . Positive_regulation IL1B CREB3 10397405 627823 This was demonstrated by showing that coexpression of stimulated native but not CRE mutant promoter and that [IL-1beta] and PMA *induced* less activity with the mutant promoter as compared to the native promoter . Positive_regulation IL1B CREB3 14999073 1216752 Using CREB antisense to determine the causal relationship between V1 agonist induced CREB activation and suppression of IL-1beta and TNF-alpha , we demonstrated that decreased [IL-1beta] and TNF-alpha gene expression was *dependent* on upstream activation . Positive_regulation IL1B CREB5 10397405 627821 This was demonstrated by showing that coexpression of stimulated native but not CRE mutant promoter and that [IL-1beta] and PMA *induced* less activity with the mutant promoter as compared to the native promoter . Positive_regulation IL1B CREB5 14999073 1216750 Using CREB antisense to determine the causal relationship between V1 agonist induced CREB activation and suppression of IL-1beta and TNF-alpha , we demonstrated that decreased [IL-1beta] and TNF-alpha gene expression was *dependent* on upstream activation . Positive_regulation IL1B CRH 11852909 913323 Indomethacin or dipyrone reduced LPS , [IL-1beta] , IL-6 or TNF-alpha *induced* fever and release from rat hypothalamus . Positive_regulation IL1B CRH 12379683 997308 We have found that *enhanced* lipopolysaccharide (LPS) induced tumor necrosis factor alpha (TNF-alpha) , [interleukin-1beta (IL-1beta)] , and IL-6 production . Positive_regulation IL1B CRH 1517398 196849 [Interleukin-1 beta] *induces* release from cultured hypothalamic cells through protein kinase C and cAMP dependent protein kinase pathways . Positive_regulation IL1B CRH 17326013 1706515 However , *had* no effect on interleukin-1alpha and [interleukin-1beta] production in these cells . Positive_regulation IL1B CRH 7588301 333844 In the absence of LPS , *up-regulated* IL-1ra and [IL-1 beta] messenger RNA expression as well as protein synthesis . Positive_regulation IL1B CRH 8646561 343009 These results suggest that not only but also AVP may *mediate* the [IL-1 beta] stimulation of ACTH secretion in the rat . Positive_regulation IL1B CRK 12421347 1013460 In comparison , [IL-1beta] *induced* the release of PGE2 , IL-6 and activated NF-kappaB , , JNK and ERK1/2 in mixed glial cultures , but failed to induce any of these responses in microglial cell cultures . Positive_regulation IL1B CRK 12649265 1080005 [Interleukin-1beta] *induced* the phosphorylation of and p38beta2 MAPK in cardiomyocytes and stimulated RNA polymerase II binding to the COX-2 promoter , COX-2 transcription , COX-2 protein synthesis , and prostaglandin E2 ( PGE2 ) release . Positive_regulation IL1B CRK 16269458 1509288 On the other hand , TNFalpha and [IL-1beta] *induced* , c-Jun N-terminal kinase (JNK) , and nuclear factor (NF)kappaB activation , pathways more closely related to stress response . Positive_regulation IL1B CRK 17920124 1844015 Moreover , the rIL-1beta induced [IL-1beta] and COX-2 expression were *reduced* by MAPK inhibitor ( SB203580 ) and JNK inhibitor ( SP600125 ) , respectively . Positive_regulation IL1B CROT 16806191 1580410 Here , we show that COT activation also requires catalytic subunit phosphorylation , since [IL-1beta] *induced* a 5-10-fold activation of a mutant unable to bind p105 . Positive_regulation IL1B CRP 20434119 2256596 We have previously reported that lupus monocytes display distinctively differing patterns of *inducing* cytokine interleukin (IL)-6 , [IL-1beta] , and tumor necrosis factor (TNF)-alpha secretion when stimulated with either immune complexes ( ICs ) or lipopolysaccharide (LPS) . Positive_regulation IL1B CRP 2454996 93469 These results indicate that human SAA and are *induced* in Hep 3B cells by products of activated monocytes but not by [IL-1 beta] , TNF-alpha , or some hepatocyte stimulating factor preparations and that a group of heterogeneous mechanisms are involved in the induction of the various human APP . Positive_regulation IL1B CRP 9256609 448380 [IL-1 beta] *induced* both and SAA production but only in the co-presence of IL-6 . Positive_regulation IL1B CSF1 12569227 1057239 Plasma interleukin (IL)-6 , IL-8 , IL-10 , granulocyte colony stimulating factor ( G-CSF ) , , and monocyte chemotactic protein 1 (MCP-1) increased significantly after the race , and urine [IL-1beta] , IL-6 , G-CSF , M-CSF , and MCP-1 *increased* significantly . Positive_regulation IL1B CSF1 1536949 180492 [Interleukin-1 beta (IL-1 beta)] expression in human blood mononuclear phagocytes is differentially *regulated* by granulocyte-macrophage colony stimulating factor ( GM-CSF ) , , and IL-3 . Positive_regulation IL1B CSF1 1536949 180498 Regulation of GM- and *induced* [IL-1 beta] mRNA expression involves transcriptional and posttranscriptional mechanisms . Positive_regulation IL1B CSF1 17666255 1776758 [IL-1beta] stimulation of nasal polyp fibroblasts *induced* expression of RANKL mRNA and secretion of . Positive_regulation IL1B CSF1 1790636 176093 neither stimulated the proliferation of synovial cells nor *induced* production of [IL-1 beta] by synovial cells . Positive_regulation IL1B CSF1 18159995 1838575 Among cytokines analyzed in the present study , [IL-1beta] , IL-5 , IL-6 , IL-12 p40 , G-CSF , IFN-gamma , KC , LIF , MIP2 , and PDGF BB increased during the early phase of cerebral wound healing , and *increased* during the middle phase , while IL-15 , IL-18 , and MIG increased during the late phase . Positive_regulation IL1B CSF1 18313744 1879830 Experiments employing neutralising antibodies indicate that exposure of co-cultured macrophages to both Ti-based particles *induces* the release of , GM-CSF , IL-6 and PGE2 through up-regulation of [IL-1beta] and TNF-alpha . Positive_regulation IL1B CSF1 8315354 222823 We demonstrate with elutriation purified human monocytes that , in contrast to lipopolysaccharide , recombinant human does not *induce* secretion of prostaglandin E2 , interleukin-6 (IL-6) , [IL-1 beta] , or tumor necrosis factor alpha , as measured by immunoassay ; Positive_regulation IL1B CSF2 10857757 704519 The role of protein kinase C and calcium in *induction* of human polymorphonuclear leukocyte [IL-1 beta] gene expression by . Positive_regulation IL1B CSF2 10903772 713210 TNF-alpha , [IL-1beta] , and PMA *induced* the release of in HBECs . Positive_regulation IL1B CSF2 11266094 796700 added to cell cultures 24 h before induction significantly *enhanced* the production of IL-1alpha , IL-1beta and TNF-alpha in controls , but only IL-1alpha and [IL-1beta] in the blood cell cultures of patients with ALL . Positive_regulation IL1B CSF2 12233876 988783 DHT exerts a suppressive effect on [IL-1beta] *induced* IL-6 , , and granulocyte-CSF production by synoviocytes . Positive_regulation IL1B CSF2 1444189 205131 as well as D3 and IFN-gamma *induced* [interleukin-1 beta (IL-1 beta)] production by the HL-60 cells , clearly indicating their importance in differentiation of these cells . Positive_regulation IL1B CSF2 14579275 1156773 Furthermore , in LC and the XS106 cell line , PACAP inhibited the *induced* stimulation of [IL-1beta] secretion and augmented IL-10 production . Positive_regulation IL1B CSF2 1536949 180493 [Interleukin-1 beta (IL-1 beta)] expression in human blood mononuclear phagocytes is differentially *regulated* by granulocyte-macrophage ( GM-CSF ) , M-CSF , and IL-3 . Positive_regulation IL1B CSF2 1790636 176092 But did not *induce* the production of [IL-1 beta] . Positive_regulation IL1B CSF2 18701168 1973941 Granulocyte-macrophage *increased* IL-8 and [IL-1beta] secretion , and CD11b-upregulation induced by single stranded bacterial DNA . Positive_regulation IL1B CSF2 19103778 2036449 The induction of TNF-alpha and [IL-1beta] was largely *due* to granulocyte-macrophage produced by infected osteoblasts , as demonstrated by inhibition with a specific neutralizing antibody . Positive_regulation IL1B CSF2 2012180 156680 In addition , [IL-1 beta] and TNF-alpha *induced* high levels of granulocyte-macrophage colony stimulating factor ( GM-CSF ) and macrophage ( M-CSF ) mRNAs . Positive_regulation IL1B CSF2 2026869 157469 Both [IL-1 beta] and TNF-alpha *induced* mRNA accumulation , with a maximum effect after 4 h of stimulation . Positive_regulation IL1B CSF2 2212667 142731 Although recently polymorphonuclear leukocytes ( PMN ) have been identified as producers of [IL-1 beta] in *response* to LPS and granulocyte/monocyte , little is known regarding the ability of other cytokines to induce the production of IL-1 beta in the PMN . Positive_regulation IL1B CSF2 2545332 114179 Monocyte [interleukin 1 beta] secretion was not *enhanced* by ; Positive_regulation IL1B CSF2 7530789 291758 IL-3 and granulocyte/macrophage *increased* secretion of IL-1 alpha , [IL-1 beta] and TNF-alpha for a majority of AML patients , whereas IL-4 decreased cytokine secretion . Positive_regulation IL1B CSF2 8228234 235720 In virus infected monocytes , induced a more rapid IFN-alpha release and *potentiated* production of TNF-alpha , [IL-1 beta] , and IL-6 . Positive_regulation IL1B CSF2 8396850 230337 There was no significant change in the basal release of tumor necrosis factor alpha (TNF-alpha) or [interleukin 1 beta (IL-1 beta)] *induced* by . Positive_regulation IL1B CSF2 8613710 353567 Transcriptional and post-transcriptional regulation of *induced* [IL-1 beta] gene expression in PMN . Positive_regulation IL1B CSF2 8613710 353568 Nuclear run-on analysis indicated that , like TNF , *increases* [IL-1 beta] transcription . Positive_regulation IL1B CSF2 8613710 353570 Thus , *increases* [IL-1 beta] message accumulation in PMN at both the transcriptional and post-transcriptional levels by mechanisms that are different from TNF induction of IL-1 beta gene expression . Positive_regulation IL1B CSF2 8780161 380048 After 24 hours , contact allergens not only increased the expression of [IL-1 beta] but also *induced* the expression of IL-1 alpha , TNF-alpha , , and IL-6 proteins mainly by suprabasal keratinocytes . Positive_regulation IL1B CSF2 9389931 467442 *stimulated* the secretion of IL-1 alpha , [IL-1 beta] and TNF gamma , but had no influence on the secretion of IL-2 , IFN alpha and IFN gamma . Positive_regulation IL1B CSF3 10320640 612200 Intravenous *increases* the release of tumour necrosis factor and [interleukin-1beta] into the cerebrospinal fluid , but does not inhibit the growth of Streptococcus pneumoniae in experimental meningitis . Positive_regulation IL1B CSF3 11011119 752636 TNF-alpha or [IL-1beta] *induced* both and PTHrP production in the conditioned medium . Positive_regulation IL1B CSF3 12569227 1057240 Plasma interleukin (IL)-6 , IL-8 , IL-10 , ( G-CSF ) , macrophage CSF (M-CSF) , and monocyte chemotactic protein 1 (MCP-1) increased significantly after the race , and urine [IL-1beta] , IL-6 , G-CSF , M-CSF , and MCP-1 *increased* significantly . Positive_regulation IL1B CSF3 2203522 140650 However , expression could be *induced* by recombinant human [IL-1 beta] ; Positive_regulation IL1B CSF3 8639772 362562 [Interleukin-1 beta] *induces* production of in human hepatoma cells . Positive_regulation IL1B CSH2 1453299 205532 Human choriogonadotropin ( hCG ) and ( hPL ) inhibit interleukin-2 (IL-2) and *increase* [interleukin-1 beta (IL-1 beta)] , -6 ( IL-6 ) and tumor necrosis factor ( TNF-alpha ) expression in monocyte cell cultures . Positive_regulation IL1B CSN2 8872182 389644 While had no significant effects on IFN gamma production by ovine blood lymphocytes , and TNF alpha production and MCH Class II antigen expression by ovine bronchoalveolar macrophages , it *enhanced* [IL-1 beta] production by the macrophages , beta-casein also had no influence on bovine NK cell activity against a virally infected cell line . Positive_regulation IL1B CSRP1 11035101 741055 In the presence of overexpressed p50 , [IL-1beta] *induced* a 3-fold increase in expression , and responses to IL-6 and to IL-6 plus IL-1beta were 4-fold greater than seen in cells without p50 overexpression . Positive_regulation IL1B CSRP1 16751406 1571067 dramatically *increased* the production of TNF-alpha and [IL-1beta] in response to S. pneumoniae . Positive_regulation IL1B CSRP1 17362204 1748276 A univariate analysis showed that the level of [IL-1beta] and IL-6 , obtained after 24 h of incubation of whole blood with LPS , *increased* significantly with increasing levels of and , after adjusting for potential confounders , IL-1beta still remained statistically significant . Positive_regulation IL1B CSRP1 17531242 1848338 In human mononuclear cells , *induced* production of tumor necrosis factor-alpha (TNF-alpha) , [interleukin-1 beta (IL-1 beta)] , and matrix metalloproteinase-9 (MMP-9) in a concentration dependent manner . Positive_regulation IL1B CSRP1 18327405 1881364 *increased* significantly the expression of the cytokines interleukin (IL)-1alpha , [IL-1beta] and IL-6 , and the chemokines GRO-alpha , GRO-beta and IL-8 . Positive_regulation IL1B CTLA4 7561084 324184 [IL-1 beta] secretion was *triggered* in a T cell independent manner by either or anti-Ia mAb in immobilized forms . Positive_regulation IL1B CTNNB1 12147254 970003 We investigated in this study the *role* of in the [IL-1beta] regulation of COX-2 expression in articular chondrocytes . Positive_regulation IL1B CTNNB1 19701245 2158070 Constitutive activation of signal transducer and activator of transcription ( STAT ) 1 in THP1 macrophages was essential for the induction of [IL-1beta] and thus for the *activation* of signaling in tumor cells . Positive_regulation IL1B CTR9 10447739 577420 We conclude that CRH and can *induce* the expression of [IL-1beta] , but this is not obligatory for increased PGE2 release , and the effect of these stimuli on COX-2 expression is a direct , IL-1beta independent effect . Positive_regulation IL1B CTR9 16025141 1453421 TNF-alpha was necessary for the local *induced* [IL-1beta] production . Positive_regulation IL1B CTR9 16439466 1554559 H ( 2 ) O ( 2 ) causes formation of [IL-1beta] that may *induce* production of in the muscle , possibly closing a self sustaining cycle of production of inflammatory mediators . Positive_regulation IL1B CTR9 16829183 1591460 Both TNF-alpha and [IL-1beta] induced HUVEC platelet activating factor (PAF) production and was *required* for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine ) . Positive_regulation IL1B CTR9 1710753 158264 , alone and in combination with endotoxin , *caused* an increase in mRNA levels for [IL-1 beta] . Positive_regulation IL1B CTR9 8080039 270828 [Interleukin-1 beta] and tumor necrosis factor-alpha *induce* production by endothelium , and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist . Positive_regulation IL1B CTSB 12726991 1086349 Results show that in normal conditions and in the presence of [IL-1beta] , is *involved* in the activation of PA . Positive_regulation IL1B CTSB 18464888 1910140 Furthermore , pre-treatment with IL-4 ( 10 ng/ml ) suppressed both MMP-13 and *induction* by mechanical stress , as well as CTS induced [IL-1beta] expression . Positive_regulation IL1B CTSB 19139407 2025655 Uptake of microparticles induced lysosomal damage , whereas particle mediated enhancement of [IL-1beta] secretion *required* phagosomal acidification and the lysosomal cysteine protease , suggesting a role for lysosomal damage in inflammasome activation . Positive_regulation IL1B CTSB 20008285 2191236 In addition , an LLO dependent but NLRP3 activation might *contribute* to some extent to the [IL-1beta] production in L. monocytogenes infected cells . Positive_regulation IL1B CTSB 20442201 2307477 Moreover , [IL-1beta] secretion was *dependent* on phagocytosis , lysosomal maturation , and L , and reactive oxygen species ( ROS ) . Positive_regulation IL1B CTSB 9366717 463334 Expression of [IL-1 beta] and TNF-alpha mRNA could not be *induced* by trypsin , chymotrypsin , or . Positive_regulation IL1B CX3CL1 18768878 1957146 Furthermore , *enhanced* the gene expression of [IL-1beta] , TNF-alpha , IFN-gamma , and IL-12 by WT macrophages with NF-kappaB activation . Positive_regulation IL1B CXCL10 10092813 600794 We found that IFN-gamma , but not TNF-alpha or [IL-1 beta] , strongly *induced* , Mig , and I-TAC mRNA accumulation mainly in NHBEC and that TNF-alpha and IL-1 beta synergized with IFN-gamma induction in all three cell types . Positive_regulation IL1B CXCL10 15774504 1397281 CXCL8 and CXCL1 production by human astrocytes at both the RNA and protein levels could be induced by interleukin (IL)-1beta , while was *induced* by both [IL-1beta] and interferon-gamma . Positive_regulation IL1B CXCL10 17484771 1778192 LPS induced production of tumour necrosis factor-alpha (TNF-alpha) , interleukin-6 (IL-6) , IL-10 and SA *induced* TNF-alpha , and [IL-1beta] production ; Positive_regulation IL1B CXCL10 18370870 1888248 blockade alleviated chronic colitis and *attenuated* the associated increase in serum amyloid A (SAA) , interleukin-12 (IL-12)p40 , tumor necrosis factor-alpha (TNF-alpha) , interferon-gamma (IFN-gamma) , IL-1 alpha , and [IL-1 beta] levels as well as in the number of CD4+ T , NKT , and NK cells that express CXCL10 and CXCR3 , compared with groups treated with control antibody ( Ab ) . Positive_regulation IL1B CXCL10 19929594 2171906 In contrast to IFN-gamma , [IL-1beta] *induces* expression rapidly but transiently , by activating classical NF-kappaB and increasing the synthesis of IRF1 . Positive_regulation IL1B CXCL10 19929594 2171910 Together , [IL-1beta] and IFN-gamma *induce* synergistically . Positive_regulation IL1B CXCL10 3136567 95906 These included c-myc and [Il-1 alpha/beta] mRNAs , *induced* by PMA plus Con A , as well as HLA-DR alpha and mRNAs in monocytes treated with IFN-gamma . Positive_regulation IL1B CXCL11 10092813 600795 We found that IFN-gamma , but not TNF-alpha or [IL-1 beta] , strongly *induced* IP-10 , Mig , and mRNA accumulation mainly in NHBEC and that TNF-alpha and IL-1 beta synergized with IFN-gamma induction in all three cell types . Positive_regulation IL1B CXCL11 16847431 1600271 In analogy with TLR ligands , tumor necrosis factor-alpha (TNF-alpha) or [interleukin-1beta (IL-1beta)] , in combination with IFN-gamma , synergistically *induced* CXCL9 and in HMVEC and human fibroblasts , two fundamental cell types delineating the joint cavity . Positive_regulation IL1B CXCL12 11489936 845472 TNF-alpha treatment mimicked alpha *induction* of NF-kappa B , [IL-1 alpha/beta] , and RANTES , as well as cell death ; Positive_regulation IL1B CXCL12 16782208 1590853 Experiments in vitro demonstrated that [IL-1beta] and myelin basic protein (MBP) *induced* in astrocytes by signaling pathways involving ERK and PI3-K . Positive_regulation IL1B CXCL16 18344492 1892187 Finally , we found that both [interleukin-1beta] and tumor necrosis factor alpha significantly *induced* production by prostate epithelial cells , thereby indicating that inflammatory cytokines may play a role in the CXCL16 induction . Positive_regulation IL1B CXCL5 9164944 432140 GCP-2 is *induced* in MG-63 , but not A549 cells by TNF-alpha , [IL-1beta] , and LPS , while is expressed in both cell types . Positive_regulation IL1B CXCL6 9164944 432141 is *induced* in MG-63 , but not A549 cells by TNF-alpha , [IL-1beta] , and LPS , while ENA-78 is expressed in both cell types . Positive_regulation IL1B CXCL9 10092813 600796 We found that IFN-gamma , but not TNF-alpha or [IL-1 beta] , strongly *induced* IP-10 , , and I-TAC mRNA accumulation mainly in NHBEC and that TNF-alpha and IL-1 beta synergized with IFN-gamma induction in all three cell types . Positive_regulation IL1B CXCL9 16847431 1600272 In analogy with TLR ligands , tumor necrosis factor-alpha (TNF-alpha) or [interleukin-1beta (IL-1beta)] , in combination with IFN-gamma , synergistically *induced* and CXCL11 in HMVEC and human fibroblasts , two fundamental cell types delineating the joint cavity . Positive_regulation IL1B CYP19A1 10715546 676439 TGF-beta1 increased [IL-1beta+DEX-] *induced* activity in osteoblast-like cells , while it inhibited activity in skin fibroblasts . Positive_regulation IL1B CYP4F11 19812349 2184075 Proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha) and [interleukin 1beta] , which can activate the AP-1 complex , *induce* transcription in HaCaT cells . Positive_regulation IL1B DDX58 17064399 1637368 We previously reported that [interleukin 1beta (IL-1beta)] *induced* expression in gingival fibroblasts . Positive_regulation IL1B DDX58 18209072 1857819 In this study , we have studied the *role* of membrane associated TLRs and cytoplasmic receptors ( RLR ) in regulation of IFN-beta , IL-29 , [IL-1beta] , and IL-18 production and caspases 1 and 3 activation in human macrophages . Positive_regulation IL1B DEFB103B 11223260 787871 Furthermore , in fetal lung explants and gingival keratinocytes , mRNA expression was *induced* by [IL-1beta] . Positive_regulation IL1B DEFB4B 10837369 699396 Mucoid Pseudomonas aeruginosa , TNF-alpha , and [IL-1beta] , but not IL-6 , *induce* human in respiratory epithelia . Positive_regulation IL1B DEFB4B 20006664 2199894 Transforming growth factor beta1 ( TGF beta 1 ) and [IL-1 beta] , two well-known tumorigenic inflammatory mediators , *induce* transcript and peptide expression in HUVECs . Positive_regulation IL1B DKC1 12732209 1087106 *upregulates* expression levels of interleukin (IL)-1alpha , [IL-1beta] , IL-6 , IL-8 , and granulocyte-macrophage colony stimulating factor in normal human fibroblasts . Positive_regulation IL1B DLL1 19639214 2113245 One possible mechanism for the indirect effects was the observed *induction* of [IL-1beta] expression by stimulation . Positive_regulation IL1B DUSP1 15485842 1347352 Our results reveal that critically *regulates* the expression of TNF-alpha and [interleukin-1 beta] in RAW264.7 cells and further suggest a central role for this phosphatase in controlling the inflammatory responses of primary macrophages to Gram positive bacterial infection . Positive_regulation IL1B DUSP1 24692548 2935238 [IL1B] rapidly *induced* expression and RNA silencing revealed a transient role in feedback inhibition of MAPKs and inflammatory gene expression . Positive_regulation IL1B DUSP1 24692548 2935239 With dexamethasone , which *induced* expression , plus [IL1B] ( co-treatment ) , DUSP1 expression was further enhanced . Positive_regulation IL1B ECM1 10540221 563349 In this study , we explored the intracellular mechanisms responsible for *induction* of [IL-1beta] using human promonocytic U937 cells transfected with the full-length human IL-1beta gene promoter connected to a reporter gene . Positive_regulation IL1B ECM1 10540221 563351 These studies suggest that the signalling pathways which mediate *induction* of [IL-1beta] expression in human monocytic cells converge at the level of PKC activation . Positive_regulation IL1B ECM2 10540221 563350 In this study , we explored the intracellular mechanisms responsible for *induction* of [IL-1beta] using human promonocytic U937 cells transfected with the full-length human IL-1beta gene promoter connected to a reporter gene . Positive_regulation IL1B ECM2 10540221 563352 These studies suggest that the signalling pathways which mediate *induction* of [IL-1beta] expression in human monocytic cells converge at the level of PKC activation . Positive_regulation IL1B EDN1 20051644 2177409 We determined the protein levels of ET-1 and IL-1beta in gingival tissues from patients and examined whether could *regulate* the expression of the [IL-1beta] gene and protein in oral epithelial cells and fibroblasts in vitro . Positive_regulation IL1B EDN1 8792802 381026 In addition , *enhanced* significantly the [IL-1 beta] mediated upregulation of VCAM-1 expression , whereas TNF-alpha mediated expression of VCAM-1 was downregulated by Et-1 . Positive_regulation IL1B EDN1 9042668 416113 We conclude that [IL-1 beta] is a stimulant of airway epithelial cell growth , and its mitogenic effects are *mediated* , in part , by endogenous production . Positive_regulation IL1B EDN1 9336394 458164 *potentiated* [interleukin-1beta] induction of nitric oxide , which might be mediated by endogenous parathyroid hormone related protein . Positive_regulation IL1B EDN1 9687319 522191 Also , TNFalpha and [IL-1beta] *induced* further release of stimulated by LH ( p < 0.05 ) . Positive_regulation IL1B EEF1A2 16942919 1673114 Increased macrophage lipid content did not block *induced* [IL-1beta] and IL-8 secretion . Positive_regulation IL1B EFS 16675961 1583968 However , these pathways were not associated with [IL-1beta] mRNA *upregulation* by . Positive_regulation IL1B EGF 10537052 562960 Among interleukin-1beta (IL-1beta) , fibroblast growth factor-2 , epidermal growth factor (EGF) , amyloid beta1-42 , and 50 % O2 , only EGF and [IL-1beta] altered the level of GIF in confluent astrocytes : *increased* both GIF mRNA and protein , and IL-1beta decreased GIF mRNA , but did not alter GIF protein . Positive_regulation IL1B EGF 11179516 784779 receptor kinase inhibitor PD153035 and AG1478 and MEK inhibitor PD98059 also *blocked* [IL-1 beta] induction of MMP-1 in cultured human keratinocytes . Positive_regulation IL1B EGF 17670913 1780545 The bioinformatic data were validated in experiments which showed that amphiregulin , but not , *results* in transcriptional up-regulation of IL-1alpha and [IL-1beta] . Positive_regulation IL1B EGF 1940795 170628 Neither nor TGF-alpha *increased* transcription rates of IL-1 alpha , [IL-1 beta] , and IL-6 genes , but rather both EGF and TGF-alpha increased cytokine mRNA stability . Positive_regulation IL1B EGF 2605216 123671 In addition , using chimeric constructs of the stromelysin promoter linked to the bacterial gene chloramphenicol acetyltransferase (CAT) , we show that the elements required for the tumor promoter phorbol myristate acetate ( PMA ) , , and [interleukin 1 beta (IL-1 beta)] *induction* are contained on a 307 base pair fragment which includes approximately 270 base pairs ( bp ) of 5'-flanking DNA . Positive_regulation IL1B EGF 9058804 417707 TGF-beta differentially modulates *mediated* increases in leukemia-inhibitory factor , IL-6 , IL-1 alpha , and [IL-1 beta] in human thymic epithelial cells . Positive_regulation IL1B EGF 9284956 451875 Expression of KGF transcript was down-regulated by , TGF-alpha , and PDGF-BB , was markedly *up-regulated* by [IL-1 beta] , and was more pronounced in limbal than in corneal fibroblasts . Positive_regulation IL1B EGFR 15266025 1275922 However , neither inhibition of activation with the tyrosine kinase inhibitor 4- ( 3-chloroanilino ) -6,7-dimethoxyquinazoline HCl ( AG-1478 ) or EGFR blocking antibody nor inhibition of extracellular signal regulated kinase/P-38 mitogen activated protein kinases with specific inhibitors *blocked* [IL-1beta] stimulation of MUC5AC mucin production . Positive_regulation IL1B EGR1 12734378 1087358 Our results indicate that A beta induced expression of cytokines ( TNF-alpha and [IL-1 beta] ) and chemokines ( MCP-1 , IL-8 , and MIP-1 beta ) in THP-1 monocytes *involves* activation of ERK-1/ERK-2 and downstream activation of . Positive_regulation IL1B ELF3 12746898 1088811 mRNA expression could be *induced* by [IL-1beta] and TNFalpha in cells such as synovial fibroblasts , chondrocytes , osteoblasts , and monocytes . Positive_regulation IL1B ENTPD1 20201036 2248975 Consistent with these observations , *regulated* P2X7 associated [IL-1beta] release after synthesis , and this process occurred independently of , and prior to , cytokine maturation by caspase-1 . Positive_regulation IL1B EPHB2 11382751 834999 The specific inhibition of either or p38 ( MAPK ) *attenuated* the [IL-1 beta-] or LIF stimulated ANF expression by up to 70 % . Positive_regulation IL1B EPHB2 11742864 887446 These data suggest that activity is *required* for persistent NF-kappaB activation by [IL-1beta] that is necessary for iNOS gene expression . Positive_regulation IL1B EPHB2 15019843 1221016 Thus , both the and JNK MAPK pathways are *necessary* for [IL-1beta] expression in TCDD stimulated human keratinocytes , however , they act at different levels to modulate IL-1beta expression . Positive_regulation IL1B EPHB2 16038626 1437395 SF significantly prevented Abeta induced increases in [IL-1beta] and p38 MAPK *activation* and also Abeta induced changes in and phospho-Akt/PKB expression levels . Positive_regulation IL1B EPHB2 16250012 1508401 [IL-1beta] also *induced* activation of and recruitment of phospho-ERK to focal complexes/adhesions . Positive_regulation IL1B EPHB2 16297883 1502770 Dioscorin also stimulated multiple signaling molecules ( NF-kappaB , , JNK , and p38 ) and *induced* the expression of cytokines ( TNF-alpha , [IL-1beta] , and IL-6 ) in murine RAW 264.7 macrophages . Positive_regulation IL1B EPHB2 16453302 1540712 [Interleukin-1 beta] induction of matrix metalloproteinase-1 transcription in chondrocytes *requires* dependent activation of CCAAT enhancer binding protein-beta . Positive_regulation IL1B EPHB2 16543474 1574615 Interestingly , whereas IL-6 production required activation of both PI3K and Ras/Erk pathways , [IL-1beta] production was *dependent* only on activation , suggesting that SHIP may also regulate the Ras/Erk pathway in macrophages . Positive_regulation IL1B EPHB2 19299480 2106075 In the present study , we demonstrate that CGRP is involved in morphine tolerance by differentially regulating the *dependent* up-regulation of [IL-1beta] , TNF-alpha , and microsomal prostaglandin E synthase-1 ( mPGES-1 ) in astrocytes and p38 dependent up-regulation of IL-6 in microglia in the rat spinal cord . Positive_regulation IL1B EPHB2 20138154 2227170 Hirsutenone , dexamethasone , inhibitor or Bay 11-7085 ( an inhibitor of NF-kappaB activation ) *reduced* the lipopolysaccharide induced production of cytokines [IL-1beta] and IL-8 , and the chemokine CCL17 . Positive_regulation IL1B ERVK-6 10615006 575782 On the other hand , the 45 kDa did not *stimulate* the production of PGE2 , [IL-1beta] , and TNF-alpha from the macrophages . Positive_regulation IL1B ESAT 20148899 2287358 , an ESX-1 substrate implicated in membrane damage , is both *necessary* and sufficient for caspase-1 activation and [IL-1beta] secretion . Positive_regulation IL1B ESR1 10568836 567947 Evidence for transcriptional *activation* of by [IL-1beta] in breast cancer cells . Positive_regulation IL1B ESR1 10568836 567950 These results provide compelling evidence for direct transcriptional *activation* of by [IL-1beta] . Positive_regulation IL1B ESX1 18503637 1958402 Collectively , these results reveal a *role* for in triggering secretion of lysosomes , as well as release of [IL-1beta] and IL-18 during mycobacteria infection . Positive_regulation IL1B ETS1 12960175 1164264 [Interleukin-1beta] *induced* the formation of complexes without affecting expression of CITED2 . Positive_regulation IL1B F2RL1 19247167 2040708 significantly *increased* the release of [IL-1beta] into the medium . Positive_regulation IL1B FARP2 19529994 2098795 Among 506 births ( GA 23-42 weeks ) , [IL-1 beta] *increased* with among preterm subgroups ( P = 0.0001 for < 32 weeks ; Positive_regulation IL1B FAS 10678925 668324 Of various inflammatory cytokines tested , only [interleukin 1beta] and tumor necrosis factor alpha *induced* Ag expression , and removal of either of these from the conditioned medium abrogated the response . Positive_regulation IL1B FAS 10924745 718411 Flow cytometric analyses demonstrated that TGF-beta1 , [IL-1beta] , and EGF did not *induce* expression on the cell surface . Positive_regulation IL1B FAS 11104808 756539 engagement *induces* the maturation of dendritic cells (DCs) , the release of [interleukin (IL)-1beta] , and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction : a new role for Fas ligand in inflammatory responses . Positive_regulation IL1B FAS 12365794 995284 [Interleukin-1beta] in intra-islet macrophages may *induce* and inducible nitric oxide synthase expression in an autocrine and paracrine manner and mediate beta cell destruction or even death of some macrophages and T cells . Positive_regulation IL1B FAS 16691186 1570036 High glucose concentrations *induce* [IL-1beta] production in human beta-cells , expression and concomitant apoptosis owing to a constitutive expression of FasL . Positive_regulation IL1B FAS 16785543 1577116 We additionally determined that [IL-1beta] and TNF-alpha secretion by beta-glucan stimulated DCs was partially *regulated* by . Positive_regulation IL1B FAS 19002429 2022199 In INS-1 cells , [IL-1beta] + IFN-gamma *induced* a tenfold and eightfold increase of mRNA expression after 6 and 24 h , respectively . Positive_regulation IL1B FAS 9396343 468792 expression was *induced* by [IL-1 beta] stimulation . Positive_regulation IL1B FASLG 11104808 756540 Fas engagement *induces* the maturation of dendritic cells (DCs) , the release of [interleukin (IL)-1beta] , and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction : a new role for in inflammatory responses . Positive_regulation IL1B FASLG 11500835 847109 We previously demonstrated that uncleavable membrane bound of mice *induces* [IL-1 beta] release from inflammatory cells , and suggested that the IL-1 beta enhances neutrophil infiltration . Positive_regulation IL1B FASLG 11500835 847110 [IL-1 beta] release from inflammatory peritoneal exudate and acceleration of tumor rejection were also *mediated* by membrane bound but not soluble . Positive_regulation IL1B FASLG 12902488 1118954 Pathogen associated molecular patterns sensitize macrophages to *induced* apoptosis and [IL-1 beta] release . Positive_regulation IL1B FASLG 16785543 1577117 We additionally determined that [IL-1beta] and TNF-alpha secretion by beta-glucan stimulated DCs was partially *regulated* by . Positive_regulation IL1B FASLG 16858424 1625428 In HaCaT cells and in reconstructed human epidermis ( RHE ) , *triggered* a NF-kappaB dependent mRNA accumulation of inflammatory cytokines ( tumor necrosis factor-alpha , IL-6 , and [IL-1beta] ) , chemokines ( CCL2/MCP-1 , CXCL1/GROalpha , CXCL3/GROgamma , and CXCL8/IL-8 ) , and the adhesion molecule ICAM-1 . Positive_regulation IL1B FCER2 11500085 846947 Cell surface stimulation of expressed by astrocytes *induced* production of nitric oxide ( NO ) and [IL-1beta] which was inhibited by a specific inducible NO-synthase (iNOS) inhibitor ( aminoguanidine ) , indicating the implication of this receptor in the astrocyte inflammatory reaction . Positive_regulation IL1B FCER2 1334783 205923 This expression *leads* to the IgE dependent production of the potent pro-inflammatory cytokines [IL-1 beta] and TNF-alpha . Positive_regulation IL1B FCGR1A 1837029 175083 Interleukin-6 induction by FcRI stimulation is not mediated solely by *induced* M phi tumor necrosis factor alpha , IL-1 alpha , or [IL-1 beta] production and is independent of M phi prostaglandin E2 levels . Positive_regulation IL1B FGB 10226077 610369 The purpose of the current work was to extend our previous observations by characterizing the transcriptional regulation of *induced* [IL-1beta] expression . Positive_regulation IL1B FGB 10226077 610370 We found that *induced* the [IL-1beta] promoter and that induction could be blocked by anti-CD18 antibody . Positive_regulation IL1B FGB 10226077 610371 This study begins to define the molecular mechanisms by which promotes and *regulates* expression of the [IL-1beta] gene and further substantiates a role for fibrin(ogen) in tissue injury and inflammation . Positive_regulation IL1B FGB 16123330 1461114 Endothelial cell activation by [IL-1beta] in the *presence* of requires alphavbeta3 . Positive_regulation IL1B FGB 8525785 331125 In conclusion , subcutaneous [interleukin-1 beta] ( probably by stimulation of interleukin-6 ) strongly *induces* and orosomucoid expression in rat liver , and suppresses immunohistochemically stainable albumin in a heterogenous way , mainly in the periportal zone . Positive_regulation IL1B FGF1 7662960 321808 To address the direct effects of FGF , we investigated whether *induced* production of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation IL1B FGF1 9389745 467225 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Positive_regulation IL1B FGF1 9555020 499579 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Positive_regulation IL1B FGF10 7662960 321809 To address the direct effects of FGF , we investigated whether *induced* production of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation IL1B FGF10 9389745 467226 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Positive_regulation IL1B FGF10 9555020 499580 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Positive_regulation IL1B FGF11 7662960 321810 To address the direct effects of FGF , we investigated whether *induced* production of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation IL1B FGF11 9389745 467227 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Positive_regulation IL1B FGF11 9555020 499581 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Positive_regulation IL1B FGF12 7662960 321811 To address the direct effects of FGF , we investigated whether *induced* production of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation IL1B FGF12 9389745 467228 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Positive_regulation IL1B FGF12 9555020 499582 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Positive_regulation IL1B FGF13 7662960 321812 To address the direct effects of FGF , we investigated whether *induced* production of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation IL1B FGF13 9389745 467229 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Positive_regulation IL1B FGF13 9555020 499583 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Positive_regulation IL1B FGF14 7662960 321813 To address the direct effects of FGF , we investigated whether *induced* production of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation IL1B FGF14 9389745 467230 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Positive_regulation IL1B FGF14 9555020 499584 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Positive_regulation IL1B FGF16 7662960 321814 To address the direct effects of FGF , we investigated whether *induced* production of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation IL1B FGF16 9389745 467231 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Positive_regulation IL1B FGF16 9555020 499585 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Positive_regulation IL1B FGF17 7662960 321815 To address the direct effects of FGF , we investigated whether *induced* production of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation IL1B FGF17 9389745 467232 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Positive_regulation IL1B FGF17 9555020 499586 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Positive_regulation IL1B FGF18 18565769 1984270 In the presence of [IL-1beta] , *increased* expression of ADAMTS-4 , aggrecan , BMP-2 , COL2A1 , CCL3 , CCL4 , CCL20 , CXCL1 , CXCL3 , CXCL6 , IL-1beta , IL-6 , and IL-8 and decreased ADAMTS-5 , MMP-13 , CCL2 , and CCL8 . Positive_regulation IL1B FGF18 7662960 321816 To address the direct effects of FGF , we investigated whether *induced* production of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation IL1B FGF18 9389745 467233 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Positive_regulation IL1B FGF18 9555020 499587 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Positive_regulation IL1B FGF19 7662960 321817 To address the direct effects of FGF , we investigated whether *induced* production of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation IL1B FGF19 9389745 467234 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Positive_regulation IL1B FGF19 9555020 499588 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Positive_regulation IL1B FGF2 10892857 711311 Both [IL-1beta] and TNF-alpha *induced* a significant decrease in uPA expression in PBF , whereas induced a slight increase in both HJF and PBF . Positive_regulation IL1B FGF2 17717918 1789482 The [IL-1beta] mRNA expression level decreased and that of *increased* in both groups after treatment significantly ( P < 0.01 ) , but showed insignificant difference between the two groups . Positive_regulation IL1B FGF2 20374325 2181242 Chondrocytes were stimulated with or without [IL-1beta] ( 10 ng/mL ) in the *presence* or absence of vascular endothelial growth factor , or hepatocyte growth factor ( 20 ng/mL ) . Positive_regulation IL1B FGF2 7662960 321818 To address the direct effects of FGF , we investigated whether *induced* production of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation IL1B FGF2 9389745 467235 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Positive_regulation IL1B FGF2 9555020 499589 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Positive_regulation IL1B FGF20 7662960 321819 To address the direct effects of FGF , we investigated whether *induced* production of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation IL1B FGF20 9389745 467236 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Positive_regulation IL1B FGF20 9555020 499590 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Positive_regulation IL1B FGF21 7662960 321820 To address the direct effects of FGF , we investigated whether *induced* production of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation IL1B FGF21 9389745 467237 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Positive_regulation IL1B FGF21 9555020 499591 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Positive_regulation IL1B FGF22 7662960 321821 To address the direct effects of FGF , we investigated whether *induced* production of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation IL1B FGF22 9389745 467238 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Positive_regulation IL1B FGF22 9555020 499592 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Positive_regulation IL1B FGF23 7662960 321822 To address the direct effects of FGF , we investigated whether *induced* production of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation IL1B FGF23 9389745 467239 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Positive_regulation IL1B FGF23 9555020 499593 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Positive_regulation IL1B FGF3 7662960 321823 To address the direct effects of FGF , we investigated whether *induced* production of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation IL1B FGF3 9389745 467240 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Positive_regulation IL1B FGF3 9555020 499594 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Positive_regulation IL1B FGF4 7662960 321824 To address the direct effects of FGF , we investigated whether *induced* production of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation IL1B FGF4 9389745 467241 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Positive_regulation IL1B FGF4 9555020 499595 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Positive_regulation IL1B FGF5 7662960 321825 To address the direct effects of FGF , we investigated whether *induced* production of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation IL1B FGF5 9389745 467242 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Positive_regulation IL1B FGF5 9555020 499596 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Positive_regulation IL1B FGF6 7662960 321826 To address the direct effects of FGF , we investigated whether *induced* production of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation IL1B FGF6 9389745 467243 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Positive_regulation IL1B FGF6 9555020 499597 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Positive_regulation IL1B FGF7 7662960 321827 To address the direct effects of FGF , we investigated whether *induced* production of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation IL1B FGF7 9389745 467244 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Positive_regulation IL1B FGF7 9555020 499598 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Positive_regulation IL1B FGF8 7662960 321828 To address the direct effects of FGF , we investigated whether *induced* production of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation IL1B FGF8 9389745 467245 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Positive_regulation IL1B FGF8 9555020 499599 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Positive_regulation IL1B FGF9 7662960 321829 To address the direct effects of FGF , we investigated whether *induced* production of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor alpha , IL-6 , granulocyte colony stimulating factor , or granulocyte-macrophage colony stimulating factor by two types of accessory cells , bone marrow ( BM ) fibroblasts and macrophages . Positive_regulation IL1B FGF9 9389745 467246 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Positive_regulation IL1B FGF9 9555020 499600 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Positive_regulation IL1B FGFR2 16827730 1586670 In cell culture serum , lipopolysaccharide and pro-inflammatory cytokines , [interleukin-1beta] and tumour necrosis factor-alpha significantly *induced* protein receptor expression , but HGFR expression was only induced by serum . Positive_regulation IL1B FN1 12081561 958397 [Interleukin-1beta] *induces* human proximal tubule cell injury , alpha-smooth muscle actin expression and production . Positive_regulation IL1B FN1 8705396 366016 Experiments were performed with PMN stimulated with either interleukin (IL)-8 , tumor necrosis factor (TNF)-alpha , or [IL-1 beta] in the *presence* or absence of . Positive_regulation IL1B FOS 7668153 322223 Chronic treatment with morphine and ethanol , but not cocaine , attenuates [IL-1 beta] *activation* of expression in the rat hypothalamic paraventricular nucleus . Positive_regulation IL1B FOS 9058778 417690 [IL-1beta] *induced* expression in corticotrophin releasing factor (CRF) neurons of paraventricular nucleus ( PVN ) of the hypothalamus , and anterior pituitary gland . Positive_regulation IL1B FPR2 19381066 2128131 Lysophosphatidylglycerol inhibits *stimulated* chemotactic migration and [IL-1beta] production from human phagocytes . Positive_regulation IL1B FUT4 11698472 878075 [IL-1beta] also *induced* O ( 2 ) ( - ) release and up-regulation of CD11b and , and both responses were inhibited by SB203580 ( p38 MAPK inhibitor ) , suggesting that p38 MAPK activation mediates IL-1beta induced O ( 2 ) ( - ) release and up-regulation of CD11b and CD15 . Positive_regulation IL1B FXYD1 7805182 292496 In vitro , *up-regulated* the release of [interleukin-1 beta] , interleukin-6 , tumor necrosis factor alpha , and granulocyte-macrophage colony stimulating factor both from human cells and from RAM and pulmonary fibroblasts . Positive_regulation IL1B GAB1 20435932 2262609 In this study , we demonstrated that significantly *enhances* TLR4- , TLR3- , and RIG-I triggered IL-6 , [IL-1beta] , and IFN-alpha/beta production in macrophages . Positive_regulation IL1B GBP1 17266443 1691427 IFN-gamma , tumor necrosis factor-alpha (TNF-alpha) , and [interleukin-1beta (IL-1beta)] *induced* the expression of , HuGBP-2 , and HuGBP-3 at similar high levels . Positive_regulation IL1B GBP2 17266443 1691428 IFN-gamma , tumor necrosis factor-alpha (TNF-alpha) , and [interleukin-1beta (IL-1beta)] *induced* the expression of HuGBP-1 , , and HuGBP-3 at similar high levels . Positive_regulation IL1B GCH1 10435048 634267 The simplest explanation of these results is that [IL-1 beta] *induces* expression of which leads to increased generation of BH4 and activation of eNOS . Positive_regulation IL1B GIF 7561114 324197 In vitro studies demonstrate that IL-6 , [IL-1 beta] , and *increase* the levels of both C4BP alpha- and C4BP beta-mRNAs , whereas TNF-alpha down-regulates these mRNAs . Positive_regulation IL1B GIF 9409229 471431 In cultured human smooth muscle cells from coronary arteries and saphenous veins , tumor necrosis factor-alpha (TNF-alpha) and [interleukin-1 beta (IL-1 beta)] *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ) , whereas selectively stimulated the expression of ICAM-1 . Positive_regulation IL1B GLMN 19747910 2158479 Through paracrine signaling molecules , TGF-beta and [IL-1beta] , cancer cells activate stromal fibroblasts and *induce* the expression of . Positive_regulation IL1B GNA13 16778360 1576824 [IL-1beta] mRNA *induction* by was suppressed by diphenyleneiodonium ( DPI ) , an NADPH oxidase inhibitor , but not by BAPTA-AM , an intracellular Ca2+ chelator . Positive_regulation IL1B GNA13 16778360 1576831 These results suggest that *regulates* [IL-1beta] mRNA induction through the reactive oxygen species-NF-kappaB pathway , while it regulates IL-6 mRNA induction through the Ca2+-NF-kappaB pathway . Positive_regulation IL1B GP2 11052809 743458 Fibronectin (FN) , a matrix highly expressed in injured tissues , can *induce* expression of [IL-1beta] in human blood monocytic cells . Positive_regulation IL1B GP5 11052809 743459 Fibronectin (FN) , a matrix highly expressed in injured tissues , can *induce* expression of [IL-1beta] in human blood monocytic cells . Positive_regulation IL1B GP6 11052809 743457 Fibronectin (FN) , a matrix highly expressed in injured tissues , can *induce* expression of [IL-1beta] in human blood monocytic cells . Positive_regulation IL1B GP9 11052809 743460 Fibronectin (FN) , a matrix highly expressed in injured tissues , can *induce* expression of [IL-1beta] in human blood monocytic cells . Positive_regulation IL1B GPI 10623445 658045 In contrast , [IL-1beta] and IL-6 production by Mbeta from young males was suppressed and IL-10 production *enhanced* following trauma-haemorrhage , whereas Mstraight from aged males produced elevated levels of IL-1beta and IL-6 and suppressed levels of IL-10 following trauma-haemorrhage . Positive_regulation IL1B GPI 19135800 2037694 The also induced a prominent *increase* in [IL-1beta] and TNF-alpha levels in the DRG and of cyclooxygenase-2 (COX-2) expression in neurons and satellite cells . Positive_regulation IL1B GPI 19308263 2052255 Plasmodium falciparum ( pfGPI ) enhanced C5a receptor expression ( CD88 ) on monocytes , and the co-incubation of monocytes with C5a and pfGPI *resulted* in the synergistic induction of cytokines ( IL-6 , TNF , [IL-1beta] , and IL-10 ) , chemokines ( IL-8 , MCP-1 , MIP1alpha , MIP1beta ) and the anti-angiogenic factor sFlt-1 in a time and dose dependent manner . Positive_regulation IL1B GRAP2 10601882 574642 iNOS induction involves activation by phosphorylation of the MAP kinase and can be *induced* in cultured astrocytes by [IL-1beta] or H2O2 . Positive_regulation IL1B GRAP2 10991908 732886 The kinase inhibitor , SB 203580 *inhibits* TNF-alpha and [IL-1beta] production in vitro and in vivo . Positive_regulation IL1B GRAP2 11032891 740437 [IL-1beta] *induces* MAPK phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation IL1B GRAP2 11259436 818715 Furthermore , the ability of IL-1beta to activate NF-kappaB is known to involve Akt , and we show here that [IL-1beta] *induces* activity in manner dependent on Akt and IkappaB kinase activation . Positive_regulation IL1B GRAP2 11382751 835000 The specific inhibition of either ERK or ( MAPK ) *attenuated* the [IL-1 beta-] or LIF stimulated ANF expression by up to 70 % . Positive_regulation IL1B GRAP2 12464556 1022199 kinase inhibitor SB 203580 *inhibits* [IL-1beta-] and TNF-alpha-synthesis ( IC ( 50 ) sof 0.052 microM and 0.46 microM ) in the same degree as p38-MAP kinase activity ( IC ( 50 ) : 0.34 microM ) . Positive_regulation IL1B GRAP2 12637577 1099338 This strategy established the *requirement* for activity for the lipopolysaccharide stimulated production of IL-10 , [IL-1beta] , and IL-6 by the monocytic cell WEHI 274 and the production of IL-6 and TNFalpha stimulated by ligation of the Fc-gamma receptor of the mast cell MC/9 . Positive_regulation IL1B GRAP2 14998552 1216644 Results indicated that both and ERK pathways are *involved* in LPS stimulated NO synthesis and the expression of [IL-1beta] and IL-6 . Positive_regulation IL1B GRAP2 15145599 1247715 Lipopolysaccharide (LPS) has a negative impact on long-term potentiation ( LTP ) in the rat hippocampus , which has been correlated with increased concentration of [interleukin-1 beta (IL-1 beta)] and *activation* of and c-Jun N-terminal kinase (JNK) . Positive_regulation IL1B GRAP2 15240007 1269935 EGF stimulated comparable or lower Erk1/2 , p38 and Akt phosphorylation while [IL-1beta] *induced* phosphorylation in the fibroblast cell lines . Positive_regulation IL1B GRAP2 15266025 1275923 However , neither inhibition of epidermal growth factor receptor (EGFR) activation with the tyrosine kinase inhibitor 4- ( 3-chloroanilino ) -6,7-dimethoxyquinazoline HCl ( AG-1478 ) or EGFR blocking antibody nor inhibition of extracellular signal regulated mitogen activated protein kinases with specific inhibitors *blocked* [IL-1beta] stimulation of MUC5AC mucin production . Positive_regulation IL1B GRAP2 15749024 1379448 Recombinant mouse [IL-1beta] *induced* strong activation of ERK1/2 , , JNK and NFkappa B , and significant release of IL-6 and PGE2 , which was blocked by IL-1ra . Positive_regulation IL1B GRAP2 15778394 1385089 [IL-1beta] rapidly *induced* phosphorylation in cells transfected with empty vector ( pcDNA3.1 ) , but was inhibited by 25 % in cells expressing DN MKK3 or DN MKK6 . Positive_regulation IL1B GRAP2 16399630 1513042 These results suggest that CHL *inhibits* [IL-1beta] production in macrophages stimulated with LPS at transcriptional level by blocking the phosphorylation of and by suppressing the activation of transcription factors , NF-kappaB , NF-IL6 , and AP-1 . Positive_regulation IL1B GRAP2 17032166 1630732 MAPK signaling is *required* for [IL-1beta] and TNF-alpha induced RANKL expression in bone marrow stromal cells . Positive_regulation IL1B GRAP2 17178391 1679714 Selective inhibitors of ( mapk ) ( SB203580 ) or of MEK1/2 , the direct upstream activator of ERK1/2 ( PD98059 ) , *reduced* the synthesis of [IL-1beta] , TNFalpha , IL-6 and IL-8 induced by either the chaperonins or LPS . Positive_regulation IL1B GRAP2 17391766 1727755 Furthermore , lipopolysaccharide , CpG oligonucleotides and recombinant trout [IL-1beta] *induced* endogenous phosphorylation of in salmon head kidney macrophages in a dose dependent manner . Positive_regulation IL1B GRAP2 17395477 1728154 The expression of TNF-alpha , IL-1beta and IL-12 was down regulated in the presence of PD98059 and SB202190 in a dose dependent manner , suggesting the involvement of p42/44 and in ConA *induced* production of TNF-alpha , [IL-1beta] and IL-12 by macrophages . Positive_regulation IL1B GRAP2 17456758 1730220 Vitamin administration or pathway inhibition also *reduced* cyclooxygenase-2 expression , tumor necrosis factor-alpha and [interleukin-1 beta] secretion , and the levels of apoptosis . Positive_regulation IL1B GRAP2 17530716 1751477 Blocking of , but not ERK-1/2 , *resulted* in inhibition of both LPS mediated [IL-1beta] gene expression and the negative effects of LPS on matrix biosynthesis . Positive_regulation IL1B GRAP2 17628610 1775164 [IL-1 beta] release and caspase-1 activity induced by DSS were significantly *inhibited* by a MAPK kinase 1/2 inhibitor , a MAPK inhibitor , and NAC , however , not by JNK1/2 or a protein kinase C inhibitor . Positive_regulation IL1B GRAP2 17983423 1850426 The effect of chondroitin sulfate on [IL-1beta] *activation* of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and was documented by immunoblot . Positive_regulation IL1B GRAP2 18296636 1878868 Whereas the induction of TNFalpha , [IL-1beta] , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation IL1B GRAP2 20302643 2238041 Increased secretion of IL-1beta was dependent upon p38 MAP kinase activity while Abeta1-40 secretion required Src family kinase activity since the specific inhibitor , SB202190 , and the Src family kinase inhibitor , PP2 , *attenuated* [IL-1beta] and Abeta1-40 secretion , respectively . Positive_regulation IL1B GSK3B 19473116 2107550 We provide evidence that the effect of Akt on [IL-1beta] activation is *mediated* by the inhibition of ( glycogen synthase kinase 3beta ) . Positive_regulation IL1B GTPBP1 20231290 2254559 PTX increased the expression of [IL-1beta] and AT1R through NF-kappaB , and a small , Rac , *mediated* PTX induced NF-kappaB activation through NADPH oxidase dependent production of reactive oxygen species . Positive_regulation IL1B GTPBP10 20231290 2254557 PTX increased the expression of [IL-1beta] and AT1R through NF-kappaB , and a small , Rac , *mediated* PTX induced NF-kappaB activation through NADPH oxidase dependent production of reactive oxygen species . Positive_regulation IL1B GTPBP2 20231290 2254560 PTX increased the expression of [IL-1beta] and AT1R through NF-kappaB , and a small , Rac , *mediated* PTX induced NF-kappaB activation through NADPH oxidase dependent production of reactive oxygen species . Positive_regulation IL1B GTPBP3 20231290 2254554 PTX increased the expression of [IL-1beta] and AT1R through NF-kappaB , and a small , Rac , *mediated* PTX induced NF-kappaB activation through NADPH oxidase dependent production of reactive oxygen species . Positive_regulation IL1B GTPBP4 20231290 2254555 PTX increased the expression of [IL-1beta] and AT1R through NF-kappaB , and a small , Rac , *mediated* PTX induced NF-kappaB activation through NADPH oxidase dependent production of reactive oxygen species . Positive_regulation IL1B GTPBP6 20231290 2254558 PTX increased the expression of [IL-1beta] and AT1R through NF-kappaB , and a small , Rac , *mediated* PTX induced NF-kappaB activation through NADPH oxidase dependent production of reactive oxygen species . Positive_regulation IL1B GTPBP8 20231290 2254556 PTX increased the expression of [IL-1beta] and AT1R through NF-kappaB , and a small , Rac , *mediated* PTX induced NF-kappaB activation through NADPH oxidase dependent production of reactive oxygen species . Positive_regulation IL1B GZMA 18951048 1989236 Moreover , murine and GzmA ( + ) cytotoxic T lymphocytes ( CTLs ) *induce* [IL-1beta] from primary mouse macrophages , and GzmA ( -/- ) mice resist lipopolysaccharide induced toxicity . Positive_regulation IL1B HAS1 15677552 1439198 Ribonuclease protection analysis revealed that steady-state transcript levels for were present at very low levels in untreated cells but *increased* as much as 18-fold in the presence of [IL-1beta] . Positive_regulation IL1B HAS1 16723203 1570379 Stimulating such cells with [IL-1beta] results in a dose and time dependent *activation* of . Positive_regulation IL1B HAS1 16904269 1672815 A series of COX inhibitors blocked [IL-1beta] *induced* activation . Positive_regulation IL1B HAS1 18444484 1900659 [IL-1beta] and TNF-alpha *induced* each other and synergistically increased and HAS-2 expression . Positive_regulation IL1B HAS1 20384487 2255765 [IL-1beta] slightly induced cAMP production , but *induced* mRNA expression of all three isoforms and HA secretion . Positive_regulation IL1B HAS2 18444484 1900660 [IL-1beta] and TNF-alpha *induced* each other and synergistically increased HAS-1 and expression . Positive_regulation IL1B HBD 10338476 615838 HBD-1 expression was constitutive , while expression was *induced* by [IL-1beta] and LPS . Positive_regulation IL1B HBD 15557089 1367891 The results showed that treatment of HBECs with HNP-1 , but not , *increased* IL-8 and [IL-1beta] mRNA expression in a dose dependent manner and also enhanced IL-8 protein secretion and NF-kappaB DNA binding activity . Positive_regulation IL1B HBD 17390080 1716122 We have previously demonstrated that [IL-1beta] *induced* mRNA expression in A549 cells through activation of nuclear factor-kappaB (NF-kappaB) transcriptional factor as well as p38 mitogen activated protein kinase (MAPK) , c-Jun N-terminal kinase (JNK) , or phosphatidylinositol-3-kinase (PI3K) . Positive_regulation IL1B HGF 16460250 1522592 After labeling with these maghemite nanoparticles , *increased* secretion of [IL-1beta] at D1 , probably inducing the increase of MMP-1 , -2 , and -3 and TIMP-2 . Positive_regulation IL1B HGF 20374325 2181243 Chondrocytes were stimulated with or without [IL-1beta] ( 10 ng/mL ) in the *presence* or absence of vascular endothelial growth factor , basic fibroblast growth factor or ( 20 ng/mL ) . Positive_regulation IL1B HGF 20726333 2306938 In cocultures , [IL-1beta] *induced* release , while CPT-11 alone or combined with IL-1beta decreased HGF secretion . Positive_regulation IL1B HGF 8698619 375309 Thus , GB-d1 cell derived [IL-1 beta] stimulates HGF production in stromal fibroblasts and up-regulated in the fibroblasts *induces* invasion of GB-d1 cells . Positive_regulation IL1B HGF 8814069 383459 [Interleukin-1 beta] *induced* expression of rheumatoid synovial tissue fibroblast antigenic HGF and activity . Positive_regulation IL1B HGF 9038658 405977 Messenger RNA levels of , but not TGF alpha , were increased , and release of HGF and [IL 1 beta] was *increased* . Positive_regulation IL1B HGF 9617441 509629 Recombinant human [IL-1 beta] *induced* release . Positive_regulation IL1B HIF1A 12101082 962456 Recombinant human [IL-1 beta] *induced* , in a time dependent manner , the nuclear translocation of , an effect associated with up-regulating the activity of this transcription factor under normoxic conditions . Positive_regulation IL1B HIF1A 17015745 1629872 Suggesting functional significance , we found that expression of [IL-1beta] in the brain *induced* astrocytic expression of , VEGF-A , and BBB permeability . Positive_regulation IL1B HIF1A 17474992 1743993 We have recently shown that hypoxia induced expression of [IL-1beta] in astrocytes is *mediated* by . Positive_regulation IL1B HIST4H4 16174862 1507565 Chromatin immunoprecipitation assays revealed that , under basal conditions , acetylated associated with the region -978 to -710 of the iNOS promoter , a region rich in gene control elements and that [IL-1beta] significantly *increased* this binding , which was further accentuated by cotreatment with TSA . Positive_regulation IL1B HLA-DRA 2005400 154739 Transcriptional *activation* of [IL-1 beta] and tumor necrosis factor-alpha genes by ligands . Positive_regulation IL1B HLA-DRB1 2005400 154740 Transcriptional *activation* of [IL-1 beta] and tumor necrosis factor-alpha genes by ligands . Positive_regulation IL1B HMGB1 10975801 729381 In the present studies , given intratracheally produced acute inflammatory injury to the lungs , with neutrophil accumulation , the development of lung edema , and *increased* pulmonary production of [IL-1beta] , TNF-alpha , and macrophage-inflammatory protein-2 . Positive_regulation IL1B HMGB1 12687539 1078780 SFMs expressed RAGE and released TNFalpha , [interleukin-1beta (IL-1beta)] , and IL-6 upon *stimulation* with . Positive_regulation IL1B HMGB1 17895302 1802744 can *induce* expression of TNF-alpha and [IL-1beta] , and formation of a pro-inflammatory loop between HMGB1 , TNF-alpha , and IL-1beta may be responsible for the prolonged and sustained inflammation in CLE . Positive_regulation IL1B HMGB1 18173740 1856040 Intracellular *transactivates* the human [IL1B] gene promoter through association with an Ets transcription factor PU.1 . Positive_regulation IL1B HMGB1 20222144 2243573 Western blots confirmed that [IL-1beta] *induced* a release of into astrocyte conditioned media . Positive_regulation IL1B HMGCR 10946846 721627 All inhibitors significantly *reduced* [interleukin-1beta] and -6 mRNA expression and their protein levels in the culture medium , and also inhibited cyclooxygenase-2 mRNA expression and their protein levels . Positive_regulation IL1B HMGCR 18684863 1973552 Here we show that inhibition of by simvastatin treatment , mimicking MKD , *results* in increased [IL-1beta] secretion in a Rac1/PI3K dependent manner . Positive_regulation IL1B HMOX1 18981090 1983358 Additionally , overexpression of NQO1 and/or *inhibited* LPS induced TNF and [IL-1beta] expression . Positive_regulation IL1B HMOX1 9751495 533558 After a 20-h culture , there was a small increase in in control islets , and [interleukin-1beta (IL-1beta)] *induced* HO-1 expression above control levels . Positive_regulation IL1B HNF4A 15550563 1380578 A dominant negative inhibited CYP8B1 gene transcription and ectopically expressed HNF4alpha *blocked* [IL-1beta] inhibition . Positive_regulation IL1B HNF4A 15550563 1380581 JNK1 phosphorylated and a JNK-specific inhibitor *blocked* the [IL-1beta] inhibition of HNF4alpha expression . Positive_regulation IL1B HNRNPF 10570261 568265 , unlike B cells , were *induced* to increase expression of [IL-1beta] , IL-1Ra , IL-8 , IL-12 p40 , RANTES , macrophage inflammatory protein-1alpha , and monocyte chemoattractant protein-1 after CD40 ligation . Positive_regulation IL1B HNRNPF 10845914 700717 Altogether , these findings suggest that CD4 ( + ) and CD8 ( + ) T-lymphocyte subsets have distinct roles in the *induction* of [IL-1beta] secretion by and support the hypothesis that IL-1beta plays a role in cell mediated immune responses . Positive_regulation IL1B HNRNPF 10861035 705057 The ligation of as well as Con A blasts by IL-12 *induced* the production of GM-CSF , [IL-1beta] , IL-6 , TNF-alpha , and IFN-gamma at the transcription levels . Positive_regulation IL1B HNRNPF 14666382 1242536 Monocyte derived were generated in a culture of monocyte with interleukin 4 (IL-4) and granulocyte-macrophage colony stimulating factor , and the maturation of DCs was *induced* by either lipopolysaccharide (LPS) or a proinflammatory cytokine cocktail : tumor-necrosis factor alpha , prostaglandin E2 , IL-6 , and [IL-1beta] . Positive_regulation IL1B HNRNPF 16622206 1551623 In addition , Campylobacter infected triggered activation of NF-kappaB and significantly *stimulated* production of [interleukin-1beta (IL-1beta)] , IL-6 , IL-8 , IL-10 , IL-12 , gamma interferon , and tumor necrosis factor alpha (TNF-alpha) compared to uninfected DCs . Positive_regulation IL1B HNRNPF 20386470 2245272 LPS stimulation of *induced* IL-10 , IL-12p70 , TNFalpha and [IL-1beta] secretion , and taxol pretreatment modified this response by down regulating IL-1beta secretion whereas colchicine induced a proinflammatory cytokine profile with reduced IL-10 and increased IL-12p70 and TNFalpha secretion . Positive_regulation IL1B HNRNPH1 10570261 568266 , unlike B cells , were *induced* to increase expression of [IL-1beta] , IL-1Ra , IL-8 , IL-12 p40 , RANTES , macrophage inflammatory protein-1alpha , and monocyte chemoattractant protein-1 after CD40 ligation . Positive_regulation IL1B HNRNPH1 10845914 700718 Altogether , these findings suggest that CD4 ( + ) and CD8 ( + ) T-lymphocyte subsets have distinct roles in the *induction* of [IL-1beta] secretion by and support the hypothesis that IL-1beta plays a role in cell mediated immune responses . Positive_regulation IL1B HNRNPH1 10861035 705058 The ligation of as well as Con A blasts by IL-12 *induced* the production of GM-CSF , [IL-1beta] , IL-6 , TNF-alpha , and IFN-gamma at the transcription levels . Positive_regulation IL1B HNRNPH1 14666382 1242537 Monocyte derived were generated in a culture of monocyte with interleukin 4 (IL-4) and granulocyte-macrophage colony stimulating factor , and the maturation of DCs was *induced* by either lipopolysaccharide (LPS) or a proinflammatory cytokine cocktail : tumor-necrosis factor alpha , prostaglandin E2 , IL-6 , and [IL-1beta] . Positive_regulation IL1B HNRNPH1 16622206 1551624 In addition , Campylobacter infected triggered activation of NF-kappaB and significantly *stimulated* production of [interleukin-1beta (IL-1beta)] , IL-6 , IL-8 , IL-10 , IL-12 , gamma interferon , and tumor necrosis factor alpha (TNF-alpha) compared to uninfected DCs . Positive_regulation IL1B HNRNPH1 20386470 2245273 LPS stimulation of *induced* IL-10 , IL-12p70 , TNFalpha and [IL-1beta] secretion , and taxol pretreatment modified this response by down regulating IL-1beta secretion whereas colchicine induced a proinflammatory cytokine profile with reduced IL-10 and increased IL-12p70 and TNFalpha secretion . Positive_regulation IL1B HRAS 14563479 1154847 Depletion of membrane bound cholesterol using methyl-beta-cyclodextrin , which also disrupts caveolar organization within the plasma membrane , abolished IL-1 beta induced NO release suggesting that [IL-1 beta] mediated *dependent* signaling in these cells involves the intermediacy of caveolae and their key constituents ( e.g. caveolin-1 ) in isolated beta cells . Positive_regulation IL1B HRAS 16543474 1574616 Interestingly , whereas IL-6 production required activation of both PI3K and Ras/Erk pathways , [IL-1beta] production was *dependent* only on activation , suggesting that SHIP may also regulate the Ras/Erk pathway in macrophages . Positive_regulation IL1B HSD17B4 9225994 443096 , like LPS , was an active *inducer* of interleukin-8 (IL-8) , tumor necrosis factor alpha (TNF-alpha) , IL-6 , and [IL-1 beta] production by PMN and monocytes from all subjects . Positive_regulation IL1B HSP90AA1 12732209 1087107 *upregulates* expression levels of interleukin (IL)-1alpha , [IL-1beta] , IL-6 , IL-8 , and granulocyte-macrophage colony stimulating factor in normal human fibroblasts . Positive_regulation IL1B HSP90AA1 15077173 1265813 Short-time inhibition of *resulted* in impaired IKK kinase activation by TNFalpha , [IL-1beta] or phorbolester PMA . Positive_regulation IL1B HSP90AA1 17599753 1774579 The aim of this study was to investigate the *roles* of age and in insulin-like growth factor 1 (IGF-1) and [interleukin-1beta (IL-1beta)] signaling in chondrocytes . Positive_regulation IL1B HSPA8 10867521 706487 We suggest that the increased expression of MC during peritonitis is in part *induced* by TNF-alpha and [IL-1beta] and may exert a cell-protective function , lessening MC damage during peritonitis . Positive_regulation IL1B HSPB1 18950704 2014399 Furthermore , co-transfection study shows that HSP27 S78/82A , two phosphorylated serine site deficient mutants , but not wild-type ( HSP27 WT ) and HSP27 S15A mutant increases TRAF6 ubiquitination and thereby *mediates* [IL-1beta] triggered IKK phosphorylation . Positive_regulation IL1B HSPD1 10814778 693365 expression was found to be *enhanced* in response to cytokines as diverse as [IL-1beta] , TNF-alpha , IL-4 , IL-6 and IL-10 . Positive_regulation IL1B HSPD1 15996195 1430197 Blocking of the p44/42 pathway decreased *induced* [IL-1beta] gene expression and protein secretion . Positive_regulation IL1B HSPD1 9686605 521796 Homogeneous Escherichia coli *induces* [IL-1 beta] and IL-6 gene expression in human monocytes by a mechanism independent of protein conformation . Positive_regulation IL1B HSPG2 17158358 1716899 In this study we investigated the *role* of phosphatidylcholine-specific phospholipase C ( ) in silica stimulated induction of TNF-alpha and [IL-1beta] and how PC-PLC activity is regulated by silica in a rat alveolar macrophage model . Positive_regulation IL1B HSPG2 17158358 1716903 We demonstrated that inhibition of , which was achieved with tricychodecan-9-yl-xanthate ( D609 ) , *blocked* the silica stimulated induction of TNF-alpha and [IL-1beta] in alveolar macrophage , suggesting that PC-PLC is involved in the silica associated inflammatory response . Positive_regulation IL1B HTR7 15128784 1245225 Functional studies indicated that activation of 5-HTR(4) and <5-HTR(7)> *enhanced* the release of the cytokines [IL-1beta] and IL-8 , while reducing the secretion of IL-12 and TNF-alpha in mature DC . Positive_regulation IL1B HYAL1 18390475 1944180 We found that activity is present in the apical and basolateral secretions from HBE cells where Hyals 1 , 2 , and 3 are expressed , and that [IL-1beta] *acts* synergistically with TNF-alpha to increase gene expression and activity . Positive_regulation IL1B HYAL2 18390475 1944181 We found that activity is present in the apical and basolateral secretions from HBE cells where Hyals 1 , 2 , and 3 are expressed , and that [IL-1beta] *acts* synergistically with TNF-alpha to increase gene expression and activity . Positive_regulation IL1B HYAL3 18390475 1944182 We found that activity is present in the apical and basolateral secretions from HBE cells where Hyals 1 , 2 , and 3 are expressed , and that [IL-1beta] *acts* synergistically with TNF-alpha to increase gene expression and activity . Positive_regulation IL1B HYAL4 18390475 1944183 We found that activity is present in the apical and basolateral secretions from HBE cells where Hyals 1 , 2 , and 3 are expressed , and that [IL-1beta] *acts* synergistically with TNF-alpha to increase gene expression and activity . Positive_regulation IL1B IAPP 10693932 671262 Both lipopolysaccharide treated THP-1 monocytes and mouse microglia showed significant increases in mature interleukin-1beta release 48 h following amyloid beta or human amylin treatment , whereas nonfibrillar rat *had* no effect on [interleukin-1beta] production by THP-1 cells . Positive_regulation IL1B ICAM1 10207838 606919 [IL-1 beta] potently *induced* expression in HGF and indomethacin , a cyclooxygenase inhibitor , enhanced ICAM-1 expression in the cells . Positive_regulation IL1B ICAM1 10741905 680027 Both IL-1alpha and [IL-1beta] *induced* expression and IL-8 and MCP-1 production at lower doses than TNF alpha or TNF beta . Positive_regulation IL1B ICAM1 11311334 804956 Membrane and mRNA expression are absent under basal conditions , but can be *induced* by IFN-gamma , [IL-1beta] , IL-4 , LPS and IL-6 with different efficiencies and time-courses . Positive_regulation IL1B ICAM1 12124212 965700 Because IL-18 is a proinflammatory cytokine known to mediate the production of TNF-alpha and [IL-1beta] and to *induce* the expression of ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) , we hypothesized that neutralization of IL-18 would attenuate lipopolysaccharide (LPS) induced cardiac dysfunction . Positive_regulation IL1B ICAM1 1357985 200320 The ( ICAM-1 ) is *induced* on endothelial cells by tumor necrosis factor-alpha (TNF-alpha) , [interleukin-1 beta (IL-1 beta)] , and lipopolysaccharide (LPS) . Positive_regulation IL1B ICAM1 1673988 155037 IFN-alpha and [IL-1 beta] , however , *induced* only small increases in expression and enhanced the lysis of the A375 cells but not the HT-29 cells by monocytes . Positive_regulation IL1B ICAM1 17332440 1747955 Peptidoglycan ( PGN ) ( TLR2 ligand ) , flagellin ( TLR5 ligand ) , and Imiquimod R837 ( TLR7 ligand ) could significantly upregulate cell surface expression of and CD18 , and *induce* the release of [IL-1beta] , IL-6 , IL-8 , growth related oncogene ( GRO ) -alpha , and superoxides of eosinophils . Positive_regulation IL1B ICAM1 20432452 2268142 [Interleukin-1beta] *induces* expression enhancing leukocyte adhesion in human rheumatoid arthritis synovial fibroblasts : involvement of ERK , JNK , AP-1 , and NF-kappaB . Positive_regulation IL1B ICAM1 20432452 2268144 Here , we demonstrated that [IL-1beta] *induces* gene expression via the de novo protein synthesis through transcription and translation , which is attenuated by pretreatment with actinomycin D and cycloheximide , respectively . Positive_regulation IL1B ICAM1 7523818 272286 These findings suggest that [IL-1 beta] , one of mediators in chronic sinusitis , is produced by PMNs , *induces* the expression of and ELAM-1 on endothelial cells , and , thereby , stimulates PMN infiltration in chronic sinusitis . Positive_regulation IL1B ICAM1 7915999 269789 [IL-1 beta] and TNF-alpha *induced* a parallel increase of both the ICAM-1 expression on EC and sICAM-1 production by EC , while IFN-gamma induced only the dose dependent enhancement of expression , but not the production of sICAM-1 , IL-4 and IL-6 did not show any effects on the ICAM-1 expression nor on the sICAM-1 production . Positive_regulation IL1B ICAM1 8639172 362516 We found that AECA IgG from WG patients do not display any significant cytotoxicity but are able to up-regulate the expression of E-selectin , and vascular cell adhesion molecule 1 and to *induce* the secretion of [IL-1 beta] , IL-6 , IL-8 , and MCP-1 . Positive_regulation IL1B ICAM1 8932586 398015 Human keratinocytes derived from skin obtained during plastic surgery were cultured in defined medium ( MCDB 153 ) and were stimulated by SP. Flow cytometry analysis showed that SP ( 10 ( -7 ) and 10 ( -5 ) M ) as well as the specific NK1 agonist Sar9Met ( O2 ) 11SP ( Sar Met ) induced a slight but significant expression of at the cell surface during treatment periods of 24 h and 48 h. SP ( 10 ( -5 ) M ) also induced a significant but transient *increase* in the production of IL-1alpha , [IL-1beta] , IL-1 receptor antagonist and IL-8 which was detectable by ELISA techniques 6 h after stimulation . Positive_regulation IL1B ICAM1 8943419 400033 Cross linking of ( CD54 ) *induces* AP-1 activation and [IL-1beta] transcription . Positive_regulation IL1B ICAM1 8943419 400037 In this study , we provide the first evidence that engagement *induces* activation of the transcription factor AP-1 and transcription of the [IL-1beta] gene using a specific Ab to cross-link ICAM-1 on a rheumatoid synovial cell line ( E11 cells ) . Positive_regulation IL1B ICAM1 9409229 471432 In cultured human smooth muscle cells from coronary arteries and saphenous veins , tumor necrosis factor-alpha (TNF-alpha) and [interleukin-1 beta (IL-1 beta)] *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of . Positive_regulation IL1B ICAM1 9610617 508783 [IL-1beta] *induced* MCP-1 , CINC , RANTES and gene expression in a time dependent manner . Positive_regulation IL1B ICAM1 9705828 526081 [IL-1 beta] *induced* , and COX activity , while it had no affect on VCAM-1 . Positive_regulation IL1B ICAM2 9409229 471433 In cultured human smooth muscle cells from coronary arteries and saphenous veins , tumor necrosis factor-alpha (TNF-alpha) and [interleukin-1 beta (IL-1 beta)] *induced* the expression of ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation IL1B ICAM3 9409229 471434 In cultured human smooth muscle cells from coronary arteries and saphenous veins , tumor necrosis factor-alpha (TNF-alpha) and [interleukin-1 beta (IL-1 beta)] *induced* the expression of ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation IL1B ICAM4 9409229 471435 In cultured human smooth muscle cells from coronary arteries and saphenous veins , tumor necrosis factor-alpha (TNF-alpha) and [interleukin-1 beta (IL-1 beta)] *induced* the expression of ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation IL1B ICAM5 9409229 471436 In cultured human smooth muscle cells from coronary arteries and saphenous veins , tumor necrosis factor-alpha (TNF-alpha) and [interleukin-1 beta (IL-1 beta)] *induced* the expression of ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation IL1B ID2 17631285 1787495 Using Northern- and Western-blot analyses , we documented that [interleukin-1beta (IL-1beta)] *induced* gene expression in VSMC in a time- and dose dependent manner . Positive_regulation IL1B IFI44 10775561 686668 These observations , combined with previous results , indicate that MAPK activation is *required* for [interleukin-1beta] induction of iNOS and that N-acetyl-L-cysteine may act as a reducing agent and facilitate interleukin-1beta induced iNOS expression through a reduction/oxidation related mechanism involving potentiation of cytokine activation of the p44/42 MAPK signaling pathway . Positive_regulation IL1B IFI44 11777983 899935 Furthermore , IL-17 , [IL-1beta] , and TNF-alpha *induced* a rapid activation of extracellular signal related kinase and p38 MAPKs , and specific MAPK inhibitors ( SB203580 , PD98059 , and U0216 ) significantly reduced IL-17- , IL-1beta- , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Positive_regulation IL1B IFI44 17395477 1728135 In the present study the quantitative *role* of and p38 in the production of TNF-alpha , [IL-1beta] and IL-12 by murine peritoneal macrophages , in vitro , on treatment with Concanavalin A ( ConA ) has been investigated . Positive_regulation IL1B IFI44 17395477 1728152 The expression of TNF-alpha , IL-1beta and IL-12 was down regulated in the presence of PD98059 and SB202190 in a dose dependent manner , suggesting the involvement of and p38 in ConA *induced* production of TNF-alpha , [IL-1beta] and IL-12 by macrophages . Positive_regulation IL1B IFNA2 10022737 590137 BCG and/or differentially *increased* [IL-1beta] , IL-6 , IL-8 , GM-CSF and TNF-alpha production in the bladder cancer cells . Positive_regulation IL1B IFNB1 11444907 834152 *inhibits* the ability of T lymphocytes to induce TNF-alpha and [IL-1beta] production in monocytes upon direct cell-cell contact . Positive_regulation IL1B IFNB1 15749911 1379789 We now show , using real-time PCR , that in astrocytes [IL-1beta] *induces* the expression of , IRF7 , CXCL10/IFN-gamma-inducible protein-10 , and CCL5/RANTES . Positive_regulation IL1B IFNB1 19783688 2147678 We propose that mediated up-regulation of the suppressor of cytokine signaling 3 expression , induced via STAT3 phosphorylation , *mediates* [IL-1beta] and IL-23 down-regulation , while IFN-beta-1a induced STAT1 phosphorylation induces IL-27p28 expression . Positive_regulation IL1B IFNB1 3533071 64902 Homogeneous *inducing* 25K factor ( [IL-1 beta] ) has connective tissue cell stimulating activities . Positive_regulation IL1B IFNG 10719060 676923 Similarly , IL-6 and potently *enhanced* [IL-1beta-] or TNF-alpha induced C3 and factor B secretion , respectively . Positive_regulation IL1B IFNG 11254616 794042 Moreover , in the chicken macrophage cell line HD-11 , CC chemokines , MGF , [IL-1beta] , and iNOS were *inducible* by , suggesting that macrophages may be one of the cell populations involved in the upregulation of these cytokines observed in vivo during infection with Eimeria . Positive_regulation IL1B IFNG 11470775 841064 Either [IL-1 beta] or IFN-gamma co-induced IL-12 with CD40L but conjointly , IL-1 beta , CD40L and synergized , *inducing* very high levels of IL-12 . Positive_regulation IL1B IFNG 11684335 875752 stimulation *increased* [IL-1beta] secretion 16-fold from THP-1 cells . Positive_regulation IL1B IFNG 11813247 907441 Zaprinast also enhanced NO production induced by LPS or IFN-gamma ( 100 U/ml ) , and in microglial cell cultures , but not in astrocyte cultures , zaprinast enhanced the basal and the *induced* production of the cytokines , TNF-alpha and [IL-1beta] , and of NO . Positive_regulation IL1B IFNG 11937564 928220 *dependent* induction of IL-6 , [IL-1beta] , TNF-alpha , inducible NO synthase , and plasminogen activator inhibitor-1 mRNAs was variably impaired , while IL-12 p40 , RANTES and macrophage inflammatory protein-1beta mRNAs were up-regulated in the absence of C/EBPbeta . Positive_regulation IL1B IFNG 11971025 933510 We found that PPAR alpha ligands ( clofibrate and WY14643 ) enhanced IL-1 beta induced COX-2 expression in human astrocytes and microglia , while inhibiting [IL-1 beta] plus *induction* of iNOS in astrocytes . Positive_regulation IL1B IFNG 12417884 1013127 TNF- alpha , [IL-1 beta] , and significantly *increased* HMVEC-L permeability . Positive_regulation IL1B IFNG 1444189 205132 GM-CSF as well as D3 and *induced* [interleukin-1 beta (IL-1 beta)] production by the HL-60 cells , clearly indicating their importance in differentiation of these cells . Positive_regulation IL1B IFNG 14630716 1210048 In the present study , we show that an octamer motif located 20 bp downstream of the proximal NF-kappa B binding site in the rat iNOS promoter is critical for [IL-1 beta] and *induction* of promoter activity in rat primary beta-cells and insulin producing RINm5F cells . Positive_regulation IL1B IFNG 1517568 196857 In THP-1 cells , *induces* cell surface expression of HLA-DR and CD54 and production of [IL-1 beta] , TNF-alpha , and IL-6 . Positive_regulation IL1B IFNG 15194876 1260124 Pretreatment of the cells with PACAP resulted in a significant decrease in LPS- or *induced* NO production as well as iNOS and [IL-1beta] mRNA levels . Positive_regulation IL1B IFNG 15229242 1269002 Silencing of GalT-2 gene with the use of antisense oligonucleotides resulted in decreased *induced* iNOS , TNF-alpha , and [IL-1beta] gene expression . Positive_regulation IL1B IFNG 15236748 1269733 In contrast , NOD macrophages failed to up-regulate [IL1beta] and IL12p40 in *response* to . Positive_regulation IL1B IFNG 15294346 1283116 In the present study we investigated the ability of macrophages from mice exposed to isobutyl nitrite to produce the inflammatory cytokine [IL-1beta] , upon *stimulation* with and LPS . Positive_regulation IL1B IFNG 15597792 1346560 TNF augments inflammation , TNF and induce coagulation , and [IL-1beta] *induces* coagulation and fibrinolysis . Positive_regulation IL1B IFNG 16371322 1493409 In hippocampal cultures exposed to LPS+IFN-gamma , TGF-beta1 was induced whereas in microglial cell cultures *induced* the secretion of [IL-1beta] . Positive_regulation IL1B IFNG 16604358 1556587 [IL-1beta] alone *induced* endoplasmic reticulum stress but failed to induce beta cell death , while alone neither caused endoplasmic reticulum stress nor induced beta cell death . Positive_regulation IL1B IFNG 16905232 1632718 OVA administration significantly decreased both spontaneous and *stimulated* [IL-1beta] and IL-6 levels in peritoneal macrophage cultures from experimental mice . Positive_regulation IL1B IFNG 17484771 1778194 LPS induced production of tumour necrosis factor-alpha (TNF-alpha) , interleukin-6 (IL-6) , IL-10 and protein-10 (IP-10); SA *induced* TNF-alpha , and [IL-1beta] production ; Positive_regulation IL1B IFNG 18586252 2019912 Results showed that high glucose and *had* a synergistic effect on the expression of MMP-1 , MMP-9 and [IL-1 beta] . Positive_regulation IL1B IFNG 19700144 2133276 Also , the presence of exogenous in the growth medium significantly *induced* IL-6 , but not [IL-1beta] or TNF-alpha , in D1 and D2 cells . Positive_regulation IL1B IFNG 20027291 2175571 Supernatants of Salmonella infected Mphi1 contained more IL-18 and [IL-1beta] as compared with supernatants of Mphi1 stimulated with isolated TLR agonists , and *induced* production in human CD56 ( + ) cells in an IL-23 and IL-1beta dependent but IL-12 independent manner . Positive_regulation IL1B IFNG 20596075 2296443 In human cells , *increased* [IL-1beta] production , and this might explain why IFNgamma is detrimental for multiple sclerosis . Positive_regulation IL1B IFNG 2111375 132928 Recombinant ( rIFN gamma ) alone did not *induce* [IL-1 beta] secretion and did not significantly increase secretion by LPS- and silica stimulated cells . Positive_regulation IL1B IFNG 2111375 132929 The *role* of in stimulating [IL-1 beta] secretion was not related to an enhancement of viability or an increase in the proportion of mezerein treated cells synthesizing DNA . Positive_regulation IL1B IFNG 2509610 120475 ( 40-100 U/ml ) *increased* the amount of IL-1 alpha and decreased [IL-1 beta] and non-IL-1 activity released , resulting in no overall change in the total amount of thymocyte mitogenic activity . Positive_regulation IL1B IFNG 2524582 112018 did not affect the LPS stimulated release of PGE2 but significantly *enhanced* the release of [IL-1 beta] . Positive_regulation IL1B IFNG 7631820 316934 In addition , the Th1 cytokine , , but not the Th2 cytokines , IL-4 and IL-10 , upregulated IL-1 beta mRNA and *increased* the release of [IL-1 beta] protein . Positive_regulation IL1B IFNG 7706742 297827 Infection induced the production of [IL-1 beta] , -6 , and -8 mRNAs , and this effect was *potentiated* by . Positive_regulation IL1B IFNG 7743669 306076 LPS , or TNF-alpha had no effect on spontaneous IL-6 production , and neither *resulted* in the secretion of [IL-1 beta] or TNF-alpha . Positive_regulation IL1B IFNG 7915999 269790 [IL-1 beta] and TNF-alpha *induced* a parallel increase of both the ICAM-1 expression on EC and sICAM-1 production by EC , while induced only the dose dependent enhancement of ICAM-1 expression , but not the production of sICAM-1 , IL-4 and IL-6 did not show any effects on the ICAM-1 expression nor on the sICAM-1 production . Positive_regulation IL1B IFNG 8069925 269992 Spontaneous and *induced* [IL-1 beta] secretion was greater in MS than in NL Mo . IFN-beta did not inhibit IFN-gamma induced secretion of monokines , which contrasts with IFN-beta 's inhibitory effect on IFN-gamma induced MHC class II expression . Positive_regulation IL1B IFNG 8069926 270000 Unlike IL-8 , the LPS stimulated production of TNF and [IL-1 beta] , as well as the TNF stimulated production of IL-1 beta , was markedly *enhanced* by over the entire incubation period ( up to 18 hr ) . Positive_regulation IL1B IFNG 8224636 234779 The restitution promoting cytokines TGF-alpha , EGF , [IL-1 beta] , and *increase* the production of bioactive TGF-beta 1 peptide in wounded IEC-6 cell monolayer . Positive_regulation IL1B IFNG 8872182 389645 While beta-casein had no significant effects on production by ovine blood lymphocytes , and TNF alpha production and MCH Class II antigen expression by ovine bronchoalveolar macrophages , it *enhanced* [IL-1 beta] production by the macrophages , beta-casein also had no influence on bovine NK cell activity against a virally infected cell line . Positive_regulation IL1B IFNG 9040478 415876 IFN-gamma induced dose dependent increases in HRPE MCP-1 , but not IL-8 , *potentiated* [IL-1 beta] and TNF-alpha induced MCP-1 production , but showed little modulation of IL-1 beta and TNF-alpha induced IL-8 production . Positive_regulation IL1B IFNG 9106231 424386 Cultures of human fetal astrocytes and microglia produce inducible nitric oxide synthase and nitric oxide in *response* to and [Interleukin 1 beta] . Positive_regulation IL1B IFNG 9244174 407977 Quantitative reverse transcription-polymerase chain reaction indicated that the m-RNA level was not increased by but was synergistically *increased* by interferon-gamma plus [interleukin-1beta] . Positive_regulation IL1B IFNG 9341739 458748 We show that gene expression of IL-1 alpha , [IL-1 beta] , IL-6 , granulocyte-colony stimulating factor , and IL-10 was *induced* in both cell fractions , whereas increased mRNA levels of and the inducible nitric oxide synthase were exclusively detected in the patients ' nonadherent MNCs . Positive_regulation IL1B IFNG 9500699 490950 In a system of rat hepatocytes in primary culture , [IL-1beta] *induced* production of both NO and . Positive_regulation IL1B IFNG 9520166 493475 In contrast , release of [IL-1beta] and IL-1ra ( IL-1 receptor antagonist ) in *response* to LPS , or LPS plus , was found to be lower in PMN from HIV positive patients than in PMN from controls , but was significant only in the case of IL-1ra . Positive_regulation IL1B IFNG 9657919 516883 [IL-1beta] and TNF-alpha synergistically *induced* IL-6 and GM-CSF and additively induced IL-8 and MCP-1 production , while IL-2 , IL-10 , IFN-alpha , and had little or no additional effects . Positive_regulation IL1B IFNG 9669207 479293 Lipopolysaccharide (LPS) and *stimulated* release of nitrite , lactate dehydrogenase ( LDH ) , TNF alpha , [IL-1 beta] and IL-8 from rat peritoneal macrophages , all of which were significantly reduced by ITU . Positive_regulation IL1B IFNG 9691088 523120 Reverse transcriptase polymerase chain reaction was used to confirm that TNF + LPS + *stimulates* the expression of both IL-1alpha and [IL-1beta] in human islets . Positive_regulation IL1B IGF1 15187154 1256442 In the absence of exogenous , [IL-1beta] ( 1 ng/ml ) did not *impair* muscle cell development . Positive_regulation IL1B IGF1 7510466 249922 [IL-1 beta] *induced* the secretion of and IGF binding protein in chondrocytes ; Positive_regulation IL1B IGFBP1 11108281 756837 Both dbcAMP and [IL-1beta] , in the presence of hormones , can independently *induce* gene expression and decidualization . Positive_regulation IL1B IGFBP1 12062820 953285 In addition [IL-1beta] , as a possible conceptus mediated factor , can *induce* expression in the presence of hormones following 3 days of incubation . Positive_regulation IL1B IGFBP1 12960035 1164225 We reported that [IL-1beta] ( 10 ng/ml ) with steroid hormones [ 36 nm estradiol-17beta , 1 microm medroxyprogesterone acetate ( P ) , and 100 ng/ml relaxin ] *induces* in vitro synthesis . Positive_regulation IL1B IGFBP7 1702762 151305 Neutralization assays using antisera to human interleukin-1 alpha ( HuIL-1 alpha ) , HuIL-1 beta , and HuIL-6 revealed that cell-free was attributable mainly to IL-1 beta and that IL-6 *augmented* the TAF activity of [IL-1 beta] in the culture supernatant . Positive_regulation IL1B IKBKB 12847684 1109052 In RA synovial membrane cells , inhibition had no effect on spontaneous TNFalpha production but significantly *reduced* [IL-1beta] , IL-6 , IL-8 , VEGF , and MMPs 1 , 2 , 3 , and 13 . Positive_regulation IL1B IKBKB 19278584 2046338 The inhibitor , SC-514 , inhibited IL-1beta induced IKappaBalpha protein activity , blocked p65 nuclear translocation , *caused* a significant reduction in [IL-1beta] induced DNA binding activity for p65 and ICAM-1 mRNA expression , and suppressed ICAM-1 expression on A549 cell surface ( all P < 0.01 ) . Positive_regulation IL1B IL10 10088668 599957 Interleukin-4 and *regulate* [IL1-beta] induced mouse primary astrocyte activation : a comparative study . Positive_regulation IL1B IL10 10452106 637586 Both endogenous and exogenous nitric oxide and *had* inhibitory effects on the LPS induced TNF alpha , [IL-1 beta] , and IL-6 secretions in mouse AM . Positive_regulation IL1B IL10 10623445 658046 In contrast , [IL-1beta] and IL-6 production by Mbeta from young males was suppressed and production *enhanced* following trauma-haemorrhage , whereas Mstraight phi from aged males produced elevated levels of IL-1beta and IL-6 and suppressed levels of IL-10 following trauma-haemorrhage . Positive_regulation IL1B IL10 11052826 743475 High plasma levels at diagnosis of ALL *had* no effect on the ex vivo TNF-alpha and [IL-1beta] production of monocytes in LPS stimulated MNC cultures . Positive_regulation IL1B IL10 11083779 750526 The inhibition of endogenous function by anti-IL-10 antibody *reduced* the production of IL-12 and IL-6 but not that of [IL-1beta] and TNF-alpha . Positive_regulation IL1B IL10 12039918 949560 IL-6 , IL-8 , tumor necrosis factor (TNF)-alpha , IL-12 and [IL-1 beta] were *induced* upon CD40 ligation and IFN-gamma stimulation , while could be induced by CD40 ligation alone and was reduced again by the addition of IFN-gamma . Positive_regulation IL1B IL10 12569227 1057241 Plasma interleukin (IL)-6 , IL-8 , , granulocyte colony stimulating factor ( G-CSF ) , macrophage CSF (M-CSF) , and monocyte chemotactic protein 1 (MCP-1) increased significantly after the race , and urine [IL-1beta] , IL-6 , G-CSF , M-CSF , and MCP-1 *increased* significantly . Positive_regulation IL1B IL10 15103492 1258351 Our results showed that [IL-1beta] *induced* an 11-fold increase in production in pediatric PMs ( 659+/-103 vs. 60+/-25 control , P < 0.05 ) . Positive_regulation IL1B IL10 15304296 1284580 [IL-1beta] was *detected* in 382 out of 384 samples , while was detected in 337 out of 384 samples . Positive_regulation IL1B IL10 15566949 1343547 Hz phagocytosed monocyte/macrophages ( MO/MQ ) secreted high levels of IL-10 , [IL-1beta] and TNF-alpha , but inhibition of proliferation was *mediated* by alone which was reversed by neutralization of the cytokine . Positive_regulation IL1B IL10 16141532 1451039 Treatment of CKBM alone *induced* the release of IL-10 and IFNgamma , but not [IL-1beta] , IL-4 , IL-6 and TNFbeta , while increase of intracellular Ca2+ concentration by A23187 triggered the release of only . Positive_regulation IL1B IL10 16375968 1547140 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL10 17022949 1641524 Relative to saline administration , [IL1beta] increased IL1beta , TNFalpha and IL6 mRNAs in the nucleus tractus solitarius (NTS) , hypothalamus , hippocampus and somatosensory cortex ( SSctx ) , but did not *induce* any changes in . Positive_regulation IL1B IL10 17484771 1778195 LPS induced production of tumour necrosis factor-alpha (TNF-alpha) , interleukin-6 (IL-6) , and interferon-gamma-inducible protein-10 (IP-10); SA *induced* TNF-alpha , and [IL-1beta] production ; Positive_regulation IL1B IL10 18050733 1833248 When the cells were pretreated with GbE ( 0.1 , 1 , and 10 microg x L ( -1 ) ) , the increases of [IL-1beta] and TNF-alpha in U937 foam cells were remarkably inhibited , but expression *increased* greatly . Positive_regulation IL1B IL10 18384650 1925542 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL10 3263855 101279 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL10 7540642 310121 Seven-day cultured monocytes/macrophages showed ( 1 ) diminished TNF-alpha production in response to IL-10 but not IL-4 ( 2 ) , diminished [IL-1 beta] production in *response* to both IL-4 and , and compared with fresh monocytes ( 3 ) , diminished CD14 expression in response to IL-4 , and ( 4 ) a lesser increase in CD23 expression in response to IL-4 . Positive_regulation IL1B IL10 8613550 353558 Whereas the in vivo regulatory effects of IL-1R appear to be limited to IL-1beta , *regulates* both [IL-1beta] and TNF-alpha in this model , reflected by a 48 % increase in BAL IL-1beta in rats treated with anti-IL-10 . Positive_regulation IL1B IL10 8835203 386088 While IL-6 , TNF-alpha , and *increased* transiently , increased levels of [IL-1 beta] mRNA expression were sustained over 44 days in most monkeys . Positive_regulation IL1B IL10 8926090 393281 Viable E. chaffeensis organisms were not required for [IL-1beta] IO , IL-8 , and mRNA *induction* , since heat killed E. chaffeensis induced identical time course responses . Positive_regulation IL1B IL10 9067646 418635 Taken together , these are the first studies that demonstrate that the depletion of endogenous via anti-IL-10 antibody results in a very significantly enhanced BCG induced IL-1 beta secretion and that the addition of exogenous IL-10 to human mononuclear cells stimulated with BCG *inhibits* [IL-1 beta] production . Positive_regulation IL1B IL10 9605267 507590 The production of tumor necrosis factor-alpha and [IL-1beta] by cultured colonic tissues was inhibited by addition of IL-10 , and conversely , it was *enhanced* by . Positive_regulation IL1B IL10 9657919 516884 [IL-1beta] and TNF-alpha synergistically *induced* IL-6 and GM-CSF and additively induced IL-8 and MCP-1 production , while IL-2 , , IFN-alpha , and IFN-gamma had little or no additional effects . Positive_regulation IL1B IL10 9681388 521060 *mediated* febrile responses in mice and [interleukin-1 beta] activation of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL11 12760902 1119659 secretion was *induced* by [IL-1beta] and transforming growth factor (TGF)-beta1 . Positive_regulation IL1B IL11 16375968 1547141 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL11 16616208 1582990 The expression of IL-6 and *increased* greatly in the presence of [IL-1beta] on day 1 and after day 14 of culture . Positive_regulation IL1B IL11 16860880 1682244 [Interleukin 1 beta] is *induced* by during decidualization of human endometrial stromal cells , but is not released in a bioactive form . Positive_regulation IL1B IL11 16860880 1682245 Exogenous increased by 28-fold the abundance of IL1B mRNA in decidualizing ESC , and total immunoreactive [IL1B] was also *increased* . Positive_regulation IL1B IL11 18384650 1925543 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL11 3263855 101280 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL11 9681388 521061 mediated febrile responses in mice and [interleukin-1 beta] *activation* of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL12A 11470775 841065 Either [IL-1 beta] or IFN-gamma co-induced IL-12 with CD40L but conjointly , IL-1 beta , CD40L and IFN-gamma synergized , *inducing* very high levels of . Positive_regulation IL1B IL12A 15730393 1377490 However , [IL-1beta] , but not IFN-gamma , *induced* p40 production by DCs without enhancing phenotypic maturation . Positive_regulation IL1B IL12A 19592492 2130643 In addition , we silenced IL-18Ralpha with small interfering RNA in primary human blood cells and observed up to 4-fold increases in the secretion of lipopolysaccharide- and *induced* [IL-1beta] , IL-6 , interferon-gamma , and CD40L . Positive_regulation IL1B IL12A 7594594 325895 Furthermore , stimulation of SCID mouse splenocytes with , in the presence of anti-IFN-gamma , *resulted* in an increase in detectable levels of [IL-1 beta] . Positive_regulation IL1B IL12A 8814267 383527 In contrast , *stimulated* the production of [IL-1 beta] and MCP-1 in TNF-alpha stimulated MNC and inhibited IL-1ra synthesis in cytokine stimulated cells . Positive_regulation IL1B IL12B 11470775 841066 Either [IL-1 beta] or IFN-gamma co-induced IL-12 with CD40L but conjointly , IL-1 beta , CD40L and IFN-gamma synergized , *inducing* very high levels of . Positive_regulation IL1B IL12B 15730393 1377491 However , [IL-1beta] , but not IFN-gamma , *induced* p40 production by DCs without enhancing phenotypic maturation . Positive_regulation IL1B IL12B 18164424 1875362 We also found that IL-17 was produced by microglia in *response* to or [IL-1beta] . Positive_regulation IL1B IL12B 18390747 1893331 IL-17A , IL-17F , and IL-23 could induce the release of chemokines GRO-alpha/CXCL1 , IL-8/CXCL8 , and MIP-1beta/CCL4 from eosinophils , while IL-17F and could also *increase* the production of proinflammatory cytokines [IL-1beta] and IL-6 . Positive_regulation IL1B IL12B 19592492 2130644 In addition , we silenced IL-18Ralpha with small interfering RNA in primary human blood cells and observed up to 4-fold increases in the secretion of lipopolysaccharide- and *induced* [IL-1beta] , IL-6 , interferon-gamma , and CD40L . Positive_regulation IL1B IL12B 7594594 325896 Furthermore , stimulation of SCID mouse splenocytes with , in the presence of anti-IFN-gamma , *resulted* in an increase in detectable levels of [IL-1 beta] . Positive_regulation IL1B IL12B 8814267 383528 In contrast , *stimulated* the production of [IL-1 beta] and MCP-1 in TNF-alpha stimulated MNC and inhibited IL-1ra synthesis in cytokine stimulated cells . Positive_regulation IL1B IL12RB1 16949558 1654171 We have previously reported that signaling *increases* CVB3 induced myocarditis and [IL-1beta/IL-18] levels in males , while IL-12 ( p35 ) /STAT4 induced IFN-gamma does not alter the severity of acute disease . Positive_regulation IL1B IL13 15191916 1280939 [IL-1beta] also *induced* promoter activity while enhancing the stability of IL-13 messenger RNA transcripts . Positive_regulation IL1B IL13 16375968 1547142 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL13 17700564 1794526 IL-33 or [IL-1beta] also *induced* IL-8 and production in naïve HUCBMCs , and enhanced production of these cytokines in IgE/anti-IgE stimulated HUCBMCs , without enhancing secretion of either PGD ( 2 ) or histamine . Positive_regulation IL1B IL13 17881510 1823679 We found that IL-33 , but not [IL-1beta] or IL-18 , *induced* and IL-6 production by mouse bone marrow derived , cultured mast cells ( BMCMCs ) independently of IgE . Positive_regulation IL1B IL13 18384650 1925544 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL13 19061890 2035539 Leishmania major : *increases* the infection induced hyperalgesia and the levels of [interleukin-1beta] and interleukin-12 in rats . Positive_regulation IL1B IL13 3263855 101281 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL13 7909801 254203 *augmented* the binding of radiolabeled [IL-1 beta] on the PMN surface with an increased number of IL-1 receptors and no change in Kd values . Positive_regulation IL1B IL13 8894439 392370 IL-4 and *increased* also [IL-1 beta] production by human microglial cells . Positive_regulation IL1B IL13 9200476 439617 *potentiated* [IL-1beta] ( 100 ng/mouse , i.v . ) Positive_regulation IL1B IL13 9550283 477747 In conclusion , the present study showed that could partially *prevent* [IL-1beta] induced inhibition of the glucose metabolism , and this effect appeared to be unrelated to NO levels . Positive_regulation IL1B IL13 9681388 521062 *mediated* febrile responses in mice and [interleukin-1 beta] activation of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL15 10692048 670699 Under these conditions [IL-1beta] production was induced almost exclusively by Th1 cells and was *dependent* on the presence and dose of IL-2 or , and on cell-cell contact , as demonstrated by double-chamber cultures . Positive_regulation IL1B IL15 10692048 670706 Preferential expression on Th1 cells of CD11b correlated with their capacity to induce [IL-1beta] production by THP-1 cells in the *presence* of IL-2 or , but anti-CD11b monoclonal antibody could not inhibit this activity . Positive_regulation IL1B IL15 11219394 763952 [IL-1beta] and TNF-alpha also *induce* in fibroblast like synoviocytes , which induces the production of IL-17 which in turn potentiates IL-1beta and TNF-alpha production in monocyte-macrophages . Positive_regulation IL1B IL15 12627325 1066909 [IL-1beta] and IFN-gamma *induce* the expression of diverse chemokines and in human and rat pancreatic islet cells , and in islets from pre-diabetic NOD mice . Positive_regulation IL1B IL15 14982947 1236573 We quantified IL-1Ra , IL-1alpha , and IL-1beta concentrations by enzyme linked immunosorbent assay in intracellular and extracellular fractions from IL-15 induced neutrophils and found that does not *increase* IL-1alpha or [IL-1beta] production but induces IL-1Ra release . Positive_regulation IL1B IL15 16375968 1547143 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL15 18384650 1925545 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL15 20620944 2286635 IL-1R1 ( hi ) iNK cells required continuous exposure to IL-1beta to retain AHR and IL-22 expression , and they proliferate in direct *response* to cDC derived and [IL-1beta] . Positive_regulation IL1B IL15 3263855 101282 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL15 9681388 521063 mediated febrile responses in mice and [interleukin-1 beta] *activation* of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL16 11171821 784103 Moreover , *activates* expression and production of proinflammatory cytokines such as [IL-1beta] , IL-6 , IL-15 , and tumour necrosis factor alpha (TNF-alpha) in human monocytes . Positive_regulation IL1B IL16 16375968 1547144 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL16 18384650 1925546 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL16 18446062 1902770 Moreover , mRNA expression of by RA-FLS *increased* after treatment with IL-17 but not with IL-15 , [IL-1beta] , and IFN-gamma . Positive_regulation IL1B IL16 3263855 101283 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL16 9681388 521064 *mediated* febrile responses in mice and [interleukin-1 beta] activation of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL17A 10469279 641083 In addition , *increased* TNF-alpha induced IL-1alpha , [IL-1beta] , and IL-6 mRNA expression in fetal mouse metatarsals and IL-1alpha and IL-6 mRNA expression in MC3T3-E1 cells . Positive_regulation IL1B IL17A 11585620 866110 While *stimulated* both [IL-1beta] and IL-6 production in astrocytes , only IL-1 was partly responsible for IL-17 induced NO release . Positive_regulation IL1B IL17A 11588011 866562 Moreover , overexpression of in the pulmonary compartment using a recombinant adenovirus encoding murine IL-17 ( AdIL-17 ) *resulted* in the local induction of tumor necrosis factor-alpha , [IL-1beta] , macrophage inflammatory protein-2 , and granulocyte colony stimulating factor ( G-CSF ) ; Positive_regulation IL1B IL17A 11777983 899871 IL-6 secretion was rapidly *induced* by , [IL-1beta] , and TNF-alpha . Positive_regulation IL1B IL17A 12064845 953425 *induces* collagenase-3 production in human osteoarthritic chondrocytes via AP-1 dependent activation : differential activation of AP-1 members by IL-17 and [IL-1beta] . Positive_regulation IL1B IL17A 12359166 994628 and TNF-alpha *stimulated* [IL-1beta] release in few subjects . Positive_regulation IL1B IL17A 17384030 1715806 was less potent as a direct MMP inducer than IL-1beta and TNF-alpha , but it *induced* [IL-1beta] and TNF-alpha production from macrophages , and IL-6 and IL-8 from gingival fibroblasts . Positive_regulation IL1B IL17A 18469800 1933220 Here we confirm that whereas [IL-1beta] and IL-6 *induce* secretion from human central memory CD4 ( + ) T cells , TGF-beta and IL-21 uniquely promote the differentiation of human naive CD4 ( + ) T cells into T ( H ) 17 cells accompanied by expression of the transcription factor RORC2 . Positive_regulation IL1B IL17A 18523258 1922796 [IL-1beta] alone or in association with IL-23 and IL-6 markedly increase IL-17 ( + ) CCR6 ( + ) memory T cells and *induce* production in CCR6 ( - ) memory T cells . Positive_regulation IL1B IL17A 19644886 2118685 Furthermore , production by gamma/delta T cells was *induced* by [IL-1beta] plus IL-23 independently of T cell receptor . Positive_regulation IL1B IL17A 19815670 2164502 IL-17A protein was detected in approximately 40 % of the supernatants and blockade , in IL-17A producing cultures , resulted in a small but significant *inhibition* of TNF-alpha ( 38 % ) , [IL-1beta] ( 23 % ) and IL-6 ( 22 % ) . Positive_regulation IL1B IL17A 19965648 2199547 Furthermore , production from the cytokine treated naive CD4 ( + ) T cells was *induced* by [IL-1beta] and this induction was blocked by IL-1R antagonist . Positive_regulation IL1B IL17A 20479237 2269539 Furthermore , is involved in the induction of serum and mucosal antibody responses by CT. Th17 cells induced by CT have a unique cytokine profile compared with those induced by IL-6 and TGF-beta , and their induction by CT *requires* cAMP dependent secretion of [IL-1beta] and beta-calcitonin gene related peptide by dendritic cells . Positive_regulation IL1B IL17A 20534450 2279263 [IL-1beta] promoted constitutive IL-22 secretion rather than acute IL-22 production in response to IL-23 and *induced* in some cells . Positive_regulation IL1B IL17A 20881253 2337377 Recruitment of CCR6 expressing Th17 cells by CCL 20 secreted from [IL-1 beta-] , TNF-alpha- , and *stimulated* endometriotic stromal cells . Positive_regulation IL1B IL17B 10639155 660422 In a survey of cytokine induction , and IL-17C *stimulate* the release of tumor necrosis factor alpha and [IL-1beta] from the monocytic cell line , THP-1 , whereas IL-17 has only a weak effect in this system . Positive_regulation IL1B IL17C 10639155 660423 In a survey of cytokine induction , IL-17B and *stimulate* the release of tumor necrosis factor alpha and [IL-1beta] from the monocytic cell line , THP-1 , whereas IL-17 has only a weak effect in this system . Positive_regulation IL1B IL17D 20416175 2246565 However , *up-regulated* the mRNA expression of fMLP-R and [IL-1beta] , and increased the release of IL-1beta ( p < 0.05 ) . Positive_regulation IL1B IL17D 20416175 2246566 It is concluded that the may *regulate* the expression of Mac-1 , fMLP-R and [IL-1beta] in human neutrophils through p38 MAPK and PI3K signal pathways . Positive_regulation IL1B IL17F 18390747 1893330 IL-17A , IL-17F , and IL-23 could induce the release of chemokines GRO-alpha/CXCL1 , IL-8/CXCL8 , and MIP-1beta/CCL4 from eosinophils , while and IL-23 could also *increase* the production of proinflammatory cytokines [IL-1beta] and IL-6 . Positive_regulation IL1B IL18 11570642 864281 *Role* of in the secretion of [Il-1beta] , sIL-1RII , and IL-1Ra by human neutrophils . Positive_regulation IL1B IL18 12022703 943289 The results obtained indicate that recombinant human ( rhIL-18 ) *induces* [IL-1beta] and , to a lesser extent , sIL-1RII production by human neutrophil isolated from peripheral blood . Positive_regulation IL1B IL18 12056480 951856 In the ileum , IFN-gamma , TNF-alpha , and [IL-1beta] were *induced* mainly by the virulent strain , whereas was induced in highest quantity by non-virulent Salmonella . Positive_regulation IL1B IL18 12438367 1016599 At 75 micro g , LPS *induced* a transient increase in [IL-1beta] and IL-18 levels in serum , whereas at 500 micro g it induced a 1.5-fold-higher level in serum , which increased till death . Positive_regulation IL1B IL18 14872485 1208426 *enhances* monocyte tumor necrosis factor alpha and [interleukin-1beta] production induced by direct contact with T lymphocytes : implications in rheumatoid arthritis . Positive_regulation IL1B IL18 14872485 1208430 dose-dependently *enhanced* the production of [IL-1beta] and TNFalpha , but not IL-10 , by monocytes following contact with RA synovial T cells or PHA prestimulated T cells . Positive_regulation IL1B IL18 16375968 1547145 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL18 18384650 1925547 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL18 19592492 2130645 In addition , we silenced IL-18Ralpha with small interfering RNA in primary human blood cells and observed up to 4-fold increases in the secretion of lipopolysaccharide- and *induced* [IL-1beta] , IL-6 , interferon-gamma , and CD40L . Positive_regulation IL1B IL18 24453428 2884404 We found that Nlrp3 ( -/- ) mice have more severe liver injury with higher plasma alanine aminotransferase ( ALT ) levels , increased activation of , and reduced *activation* of [IL-1B] . Positive_regulation IL1B IL18 3263855 101284 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL18 9449707 483953 ( IFNgamma inducing factor ) *induces* IL-8 and [IL-1beta] via TNFalpha production from non-CD14+ human blood mononuclear cells . Positive_regulation IL1B IL18 9449707 483962 In purified CD14+ cells but not CD3+/CD4+ , *induced* gene expression and synthesis of IL-8 and [IL-1beta] . Positive_regulation IL1B IL18 9681388 521065 mediated febrile responses in mice and [interleukin-1 beta] *activation* of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL19 16375968 1547146 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL19 18246602 1865215 also promoted neutrophil chemotaxis , reduced neutrophil apoptosis , and *induced* the production of proinflammatory cytokines and chemokines ( [IL-1[beta] ] , IL-6 , IL-8 , CCL5 , and CXCL9 ) in lung epithelial cells . Positive_regulation IL1B IL19 18384650 1925548 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL19 3263855 101285 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL19 9681388 521066 *mediated* febrile responses in mice and [interleukin-1 beta] activation of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL1A 10381547 624239 In both young and old rats , [IL-1beta] *induced* a significant up-regulation of cerebellar IL-1Ra , , and TGF-beta1 mRNAs ; Positive_regulation IL1B IL1A 10401634 628880 Following cholinergic lesion neither [IL-1 beta] nor IL-6 expression could be *detected* in any of the activated glial cell types , whereas was found to be expressed in astroglial cells only . Positive_regulation IL1B IL1A 11007768 752580 Human chondrocytes that overexpressed IL-1RII were resistant to induced [IL-1beta] mRNA *accumulation* and inhibition of proteoglycan synthesis . Positive_regulation IL1B IL1A 11108714 794763 The viral replicative intermediate dsRNA stimulates beta-cell production of [pro-IL-1beta] , and following cleavage to its mature form by IFN-gamma activated ICE , then *initiates* beta-cell damage in a nitric oxide dependent fashion . Positive_regulation IL1B IL1A 11526216 853142 Furthermore , a bacterial mutant that does not induce expression but *induces* normal levels of [IL-1 beta] , TNF-alpha , and IFN-gamma , causes greatly reduced intestinal inflammation and is attenuated by LD ( 50 ) analysis in the C57BL/6 mouse model . Positive_regulation IL1B IL1A 11998897 939561 LPS induced IL-1beta release is followed by *induced* [IL-1beta] release , an amplification process termed `` autoinduction . '' Positive_regulation IL1B IL1A 1292636 207781 NMRI/KI thymocytes showed the most prominent proliferation in *response* to and [IL-1 beta] . Positive_regulation IL1B IL1A 1427978 202483 Moreover , we report that the block of mRNA transcription consequently *leads* to the inhibition of IL-1 alpha and [IL-1 beta] secretion in human PBMC , as measured by ELISA method . Positive_regulation IL1B IL1A 15036245 1223860 We compared the production of IL-1alpha , [IL-1beta] , and of IL-1Ra isoforms by cultured human dermal ( HDF ) and synovial fibroblasts ( HSF ) in *response* to , TNF-alpha , or direct T cell membrane contact . Positive_regulation IL1B IL1A 1533322 186461 A 10-fold molar excess of IL-1ra over IL-1 beta reduced IL-1 beta induced IL-1 alpha by 95 % ( P = .01 ) and *induced* [IL-1 beta] by 73 % ( P less than .01 ) . Positive_regulation IL1B IL1A 15942912 1415774 Gammalinolenic acid suppresses inflammation by acting as a competitive inhibitor of prostaglandin E2 and leukotrienes ( LTs ) and by reducing the auto-induction of *induced* [pro-IL-1beta] gene expression . Positive_regulation IL1B IL1A 16000387 1447306 In the present study , incubation of AM with unopsonized Pneumocystis organisms was not associated with release of , IL-6 , or tumor necrosis factor (TNF)-alpha ( important cytokines in the host response to Pneumocystis ) and did not *induce* [IL-1beta] , IL-6 , or TNF-alpha mRNA transcripts . Positive_regulation IL1B IL1A 1661739 172709 *Induction* of [interleukin-1 beta] production in human dermal fibroblasts by and tumor necrosis factor-alpha . Positive_regulation IL1B IL1A 16912431 1602079 The results show that LPS and IL-1alpha increase intracellular [IL-1beta] and Diacerein inhibited LPS induced and *induced* IL-1beta production by articular chondrocytes . Positive_regulation IL1B IL1A 18516292 1918512 Recruitment of myeloid cells requires [IL-1beta] but is *regulated* by , because inflammatory chemokine and cytokine expression is stronger in IL-1alpha ( -/- ) beta ( comp ) than in IL-1 ( wt ) lines . Positive_regulation IL1B IL1A 18609176 1972348 Cultures of human primary hepatocytes showed that is *induced* by [IL-1beta] , but not IL-6 . Positive_regulation IL1B IL1A 1918980 168440 We have previously demonstrated that and TNF could rapidly , but transiently , *induce* gene expression of [Il-1 beta] in human polymorphonuclear leukocytes ( PMN ) at both the protein and mRNA level . Positive_regulation IL1B IL1A 1918980 168444 Using nuclear run-on transcription analysis , we found that within 1 h Il-1 , TNF , and TNF plus *induced* the transcription of the [Il-1 beta] gene by 33- , 61- , and 99-fold , respectively . Positive_regulation IL1B IL1A 1918980 168447 Thus , we report that and TNF *regulate* [IL-1 beta] gene expression via both transcriptional and post-transcriptional mechanisms in vitro . Positive_regulation IL1B IL1A 1920018 168476 As determined by ELISA of tissue extracts , [IL-1 beta] and TNF alpha were *detected* in all diseased sites , whereas was present in 8/22 sites , IL-1 beta was present in highest concentration ( mean +/- SEM : 11,695 +/- 2,888 pg/ml ; 672 pM ) , followed by TNF alpha ( 434 +/- 135 pg/ml ; 26 pM ) , and IL-1 alpha ( 342 +/- 160 pg/ml ; 20 pM ) . Positive_regulation IL1B IL1A 1954872 172416 [Interleukin-1 beta] *induces* messenger ribonucleic acid expression in primary cultures of Leydig cells . Positive_regulation IL1B IL1A 19569215 2208819 We added both lipopolysaccharide (LPS)-free and endotoxin associated xUHMWPE and PCU particles to a human monocyte cell line ( TH1 ) in culture and measured cell viability and tumor necrosis factor (TNF)alpha , , and prostaglandin E ( 2 ) ( PGE ( 2 ) ) in the medium after 24 h. Results indicate that particles ( both xUHMWPE and PCU ) free of endotoxin did not significantly *induce* secretion of TNFalpha , [IL-1beta] , or PGE ( 2 ) above basal levels . Positive_regulation IL1B IL1A 19648252 2125414 ( 0.001-10 ng/ml , 0-6 h ) *stimulated* [IL-1beta] , TNF-alpha , and IL-6 mRNA expression with distinct temporal and concentration profiles , resulting in increased cytokine secretion . Positive_regulation IL1B IL1A 2113076 135558 *stimulated* both [IL-1 beta] and TNF-alpha , but there was no correlation in the amount of TNF-alpha or IL-1 beta synthesized in the PBMC of 29 individuals . Positive_regulation IL1B IL1A 21219853 2392110 In the presence of BAY , *induced* [IL1B] mRNA levels were decreased by 6-fold . Positive_regulation IL1B IL1A 2484299 125197 The results indicate that human corneal E- and FLE-type cells can produce and release and that FLE cells can be *induced* by inflammatory mediators to increase production of [IL-1 beta] . Positive_regulation IL1B IL1A 2528591 117369 This response to plus IL-2 could be *induced* by IL-1 alpha or [IL-1 beta] and by membrane bound IL-1 on macrophages . Positive_regulation IL1B IL1A 2646146 108711 BSF-2/IL-6 , GM-CSF and [IL-1 beta] mRNAs were *induced* by recombinant in human astrocytoma cell line U373MG . Positive_regulation IL1B IL1A 2788284 116862 Recombinant ( alpha and beta ) *stimulated* fibroblast [IL-1 beta] mRNA accumulation , whereas recombinant TNF did not . Positive_regulation IL1B IL1A 2788284 116866 In addition , simultaneous stimulation with recombinant ( alpha or beta ) and recombinant TNF *resulted* in a synergistic increase in [IL-1 beta] mRNA levels . Positive_regulation IL1B IL1A 3131429 92710 IFN-gamma inhibited IL-1 beta induced IL-1 alpha as well as *induced* [IL-1 beta] production ; Positive_regulation IL1B IL1A 3263855 101296 Both recombinant and IL-1 beta *caused* a dramatic increase in [IL-1 beta] mRNA levels , IL-1 alpha being more efficient than IL-1 beta . Positive_regulation IL1B IL1A 3266187 103880 We have demonstrated that recombinant *induces* IL-1 alpha and [IL-1 beta] production by human vascular endothelial cells ( EC ) in vitro . Positive_regulation IL1B IL1A 3497982 77895 The results of these neutralizations showed that recombinant human *induces* the synthesis of [IL-1-beta] in human MNC in vitro . Positive_regulation IL1B IL1A 3497982 77897 These results demonstrate that *induces* biologically active and immunoreactive [IL-1-beta] from MNC in vitro and that the same concentrations of IL-1-alpha induce gene expression for both forms of IL-1 . Positive_regulation IL1B IL1A 7473001 331450 Addition of BK , in the presence of TNF alpha , for 1 h and 6 h , respectively , synergistically *enhanced* the TNF alpha induced [IL-1 beta] production , whereas BK alone did not induce production . Positive_regulation IL1B IL1A 7485466 326840 [IL-1 beta] *induced* production of both IL-1Ra and at each time point and concentration tested . Positive_regulation IL1B IL1A 7994029 283054 Production of granulocyte-macrophage colony stimulating factor ( GM-CSF ) , granulocyte-CSF (G-CSF) , and [interleukin-1 beta (IL-1 beta)] in stromal cell layers was *induced* by incubation with , tumor necrosis factor (TNF) , or lipopolysaccharide (LPS) . Positive_regulation IL1B IL1A 8048540 267132 For mononuclear cells , IL-1ra inhibited 6-h LPS- and *induced* [IL-1 beta] release to 66 +/- 4 % ( P = 0.001 by paired t test ) and 39 +/- 7 % ( P = 0.0005 by paired t test ) of control , respectively . Positive_regulation IL1B IL1A 8048540 267134 In addition , IL-1ra reduced both LPS- and *stimulated* [IL-1 beta] mRNA levels to 78 and 37 % of control , respectively . Positive_regulation IL1B IL1A 8234146 235986 PAL significantly inhibited the [IL-1 beta] production *induced* by or PMA without inhibition of total protein synthesis and cytotoxicity . Positive_regulation IL1B IL1A 8234146 235987 A protein kinase C ( PKC ) inhibitor , staurosporine , also suppressed the [IL-1 beta] production *induced* by or PMA , suggesting that the PKC pathway plays an important role in IL-1 alpha induced IL-1 beta production . Positive_regulation IL1B IL1A 8234146 235988 The calcium ionophore A23187 ( A23187 ) potentiated the [IL-1 beta] production *induced* by . Positive_regulation IL1B IL1A 8325995 223381 IL-1 alpha induced IL-1 beta synthesis was enhanced two to threefold by histamine concentrations from 10 ( -6 ) -10 ( -4 ) M. Cimetidine , an H2 receptor antagonist , reversed the histamine ( 10 ( -5 ) M ) -mediated increase in *induced* [IL-1 beta] synthesis . Positive_regulation IL1B IL1A 8325995 223382 Indomethacin , a cyclooxygenase inhibitor , significantly reduced *induced* [IL-1 beta] synthesis , but had no effect on the histamine mediated increase in IL-1 alpha induced IL-1 beta synthesis . Positive_regulation IL1B IL1A 8325995 223383 However , histamine reduced IL-1 beta mRNA half-life ( 2.4 vs 1.2 h ) , suggesting that histamine enhances *induced* [IL-1 beta] synthesis at the level of transcriptional activation . Positive_regulation IL1B IL1A 8489769 219330 Radioimmunoassay showed that after stimulation by RA , the [IL-1 beta] intracellular level is predominantly *increased* , with no significant modification of expression . Positive_regulation IL1B IL1A 8541550 338738 We found that these cells produce [IL-1 beta] and bind the biotinylated cytokine and that inhibitors , such as IL-1 neutralizing antibodies , IL-1 receptor antagonist , and soluble IL-1 receptors , specifically *inhibit* OCI/AML3 proliferation , indicating that IL-1 beta is an autocrine growth factor for OCI/AML3 cells . Positive_regulation IL1B IL1A 8698389 365857 Three weeks after ending aspirin medication , ex vivo [IL-1 beta] and TNF synthesis *induced* by exogenous was elevated threefold compared to the pre-aspirin value ( P = 0.01 and P = 0.005 , respectively ) . Positive_regulation IL1B IL1A 8698389 365858 However , *induced* synthesis of [IL-1 beta] was elevated to a mean individual increase of 538 % ( P < 0.001 ) and synthesis of TNF was elevated to 270 % ( P < 0.001 ) at the end of ibuprofen medication and 2 weeks after discontinuation of ibuprofen . Positive_regulation IL1B IL1A 8780161 380049 After 24 hours , contact allergens not only increased the expression of [IL-1 beta] but also *induced* the expression of , TNF-alpha , GM-CSF , and IL-6 proteins mainly by suprabasal keratinocytes . Positive_regulation IL1B IL1A 8941673 399297 By semiquantitative reverse transcriptase PCR , we demonstrated that and IL-1beta *stimulated* the expression of KGF , HGF , IL-1alpha , [IL-1beta] , IL-1RI , and IL-8 in fibroblasts regardless of their physiologic condition , whereas that of TGF-beta remained unaffected . Positive_regulation IL1B IL1A 9249578 446839 To evaluate the *role* of residual production in [IL-1 beta] -/- mice , we used IL-1-receptor antagonist (IL-1ra) . Positive_regulation IL1B IL1A 9712071 527176 Like IFN-beta , IFN-gamma suppresses the expression of both LPS and *induced* [IL-1beta] . Positive_regulation IL1B IL1A 9719938 528496 This study suggested that the patients with bladder cancer renal cell carcinoma and prostatic cancer did not spontaneously produce IL-1 alpha or [IL-1 beta] , but that the ability to produce and IL-1 beta in response to LPS stimulation was not significantly *impaired* . Positive_regulation IL1B IL1R1 10593617 572719 Treatment with IL-1ra blocked IL-1beta induced increases in [ Ca2+ ] i , indicating that [IL-1beta] *acts* through the . Positive_regulation IL1B IL1R1 10704249 672796 Activation of neutral sphingomyelinase by [IL-1beta] *requires* the type 1 . Positive_regulation IL1B IL1R1 7524717 276845 agonists , recombinant murine IL-1 alpha ( rmIL-1 alpha , 10 ng/ml ) and recombinant rat [IL-1 beta] ( rrIL-1 beta , 100 pg/ml or 10 ng/ml ) *induce* the upregulation of mRNA expression for both types of IL-1 receptors (IL-1Rs) . Positive_regulation IL1B IL1R2 10704249 672797 Activation of neutral sphingomyelinase by [IL-1beta] *requires* the type 1 . Positive_regulation IL1B IL1RAP 9681388 521067 Interleukin-1 mediated febrile responses in mice and [interleukin-1 beta] activation of NFkappaB in mouse primary astrocytes , *involves* the . Positive_regulation IL1B IL1RN 10381547 624240 In both young and old rats , [IL-1beta] *induced* a significant up-regulation of cerebellar , IL-1RI , and TGF-beta1 mRNAs ; Positive_regulation IL1B IL1RN 10704249 672807 In the *presence* of an , [IL-1beta] did not activate nSMase either in the cortex of wild-type or knock-out mice . Positive_regulation IL1B IL1RN 12010575 941238 The levels of were undetectable in culture supernatants of untreated cells , but were significantly *increased* by [IL-1beta] . Positive_regulation IL1B IL1RN 12690937 1030516 Plasma [IL-1 beta] rose significantly 2 h after exercise , but plasma *increased* more rapidly and markedly than IL-1 beta , thus IL-1 bioactivity should be blocked at least in the circulation . Positive_regulation IL1B IL1RN 14672890 1189148 Consistently , [IL1beta] and IFNbeta *induced* sIL1Ra mRNA expression in chondrocytes , while expression of was not detectable . Positive_regulation IL1B IL1RN 14982947 1236574 We quantified IL-1Ra , IL-1alpha , and IL-1beta concentrations by enzyme linked immunosorbent assay in intracellular and extracellular fractions from IL-15 induced neutrophils and found that IL-15 does not increase IL-1alpha or [IL-1beta] production but *induces* release . Positive_regulation IL1B IL1RN 15300797 1283746 Furthermore , constitutive [IL-1beta] secretion by AML blasts was *detected* only for a subset of patients , whereas relatively high levels of were observed for all patients ; Positive_regulation IL1B IL1RN 17003335 1618371 Low [IL-1beta] also *induced* the , suppression of which by RNA interference abrogated the beneficial effects of low IL-1beta . Positive_regulation IL1B IL1RN 17429083 1724058 The expression of is reduced in pancreatic islets of patients with type 2 diabetes mellitus , and high glucose concentrations *induce* the production of [interleukin-1beta] in human pancreatic beta cells , leading to impaired insulin secretion , decreased cell proliferation , and apoptosis . Positive_regulation IL1B IL1RN 17689191 1873856 The data showed that : ( 1 ) astrocytes produce [IL-1beta] , ( 2 ) IL-1RI is localized in Fos- and NR1-immunoreactive neurons within the spinal dorsal horn , and ( 3 ) at 0.01mg/rat significantly *increased* PWL ( P < 0.05 ) and inhibited NR1 phosphorylation compared to saline control . Positive_regulation IL1B IL1RN 1831680 165086 In the presence of 1 % AB serum , there was no increase in [IL-1 beta] ( 0.25 +/- 0.13 ng/mL ) but production *increased* sevenfold to 3.4 +/- 0.5 ng/mL . Positive_regulation IL1B IL1RN 19087877 2060558 Expression of may represent an endogenous mechanism of down regulating the effects of epithelial- and tear *derived* IL-1alpha and [IL-1beta] on the intact epithelium in the unwounded cornea and stromal cells after injury . Positive_regulation IL1B IL1RN 19428986 2077191 Immunohistochemically we could *detect* [IL-1beta] and IL-1R t1 protein in all proliferative and secretory phase samples with maximum intensity in secretory phase samples whereas was expressed in secretory phase samples only . Positive_regulation IL1B IL1RN 3262586 97880 The more strongly *suppressed* human recombinant [IL-1 beta] than human recombinant IL-1 alpha . Positive_regulation IL1B IL1RN 7485466 326841 [IL-1 beta] *induced* production of both and IL-1 alpha at each time point and concentration tested . Positive_regulation IL1B IL1RN 7485466 326850 These results are suggestive of an autocrine *role* for cell associated , as well as for IL-1 alpha and [IL-1 beta] , in the regulation of VSMC function . Positive_regulation IL1B IL1RN 8179914 256096 In contrast to mononuclear phagocytes , IL-1 alpha , [IL-1 beta] , and TNF-alpha did not *induce* further production in alveolar macrophages . Positive_regulation IL1B IL1RN 8395334 228482 [Interleukin-1 beta] *induces* and tumor necrosis factor binding protein in humans . Positive_regulation IL1B IL1RN 8604710 352370 [IL-1-beta] was *detected* in 8 % of the episodes and , although was found in 92 % of the patients , the dialysate levels were more than 15 times higher . Positive_regulation IL1B IL1RN 8613550 353561 These findings suggest that is an intrinsic regulator of inflammatory injury after deposition of IgG immune complexes and that it *regulates* production of [IL-1beta] . Positive_regulation IL1B IL1RN 9572400 501800 On the other hand , there was no change in serum levels of [IL-1beta] and IL-8 , and the serum levels of and IL-6 even *increased* at the end of a single PE , in spite of high levels of all cytokines and adhesion molecules in the plasma filtrate . Positive_regulation IL1B IL1RN 9629245 512200 We conclude that IL-1 alpha and [IL-1 beta] production in the brain is *induced* in the same cell types , whereas is expressed constitutively by a different cell type -- probably neurons . Positive_regulation IL1B IL2 10692048 670700 Under these conditions [IL-1beta] production was induced almost exclusively by Th1 cells and was *dependent* on the presence and dose of or IL-15 , and on cell-cell contact , as demonstrated by double-chamber cultures . Positive_regulation IL1B IL2 10692048 670707 Preferential expression on Th1 cells of CD11b correlated with their capacity to induce [IL-1beta] production by THP-1 cells in the *presence* of or IL-15 , but anti-CD11b monoclonal antibody could not inhibit this activity . Positive_regulation IL1B IL2 10779760 687475 Furthermore , HA markedly suppressed the ability of to *induce* [IL-1 beta] , TNF-alpha , IL-6 , and IL-8 mRNA expression and protein secretion by monocytes . Positive_regulation IL1B IL2 11521964 852609 CLA supplementation did not alter the in vitro secretion of prostaglandin E2 , leukotriene B4 , [interleukin-1beta (IL-1beta)] , or tumor necrosis factor alpha (TNFalpha) by PBMC simulated with lipopolysaccharide , and the secretion of by PBMC *stimulated* with phytohemagglutinin . Positive_regulation IL1B IL2 16375968 1547147 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL2 18384650 1925549 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL2 19762486 2168301 Stimulation of CD56+ cells containing both DCs and abundant gammadelta T cells with zoledronate and *resulted* in the rapid expansion of gammadelta T cells as well as in IFN-gamma , TNF-alpha , and [IL-1beta] but not in IL-4 , IL-10 , or IL-17 production . Positive_regulation IL1B IL2 2144468 140064 [Pro-interleukin-1 beta] production by a subpopulation of human T cells , but not NK cells , in *response* to . Positive_regulation IL1B IL2 2144468 140067 We examined cytokine production by IL-2 treated , nonmonocytic PBMC and found that a population of nonadherent low-density cells ( NLDC ) produced both [IL-1 beta] and TNF alpha in *response* to . Positive_regulation IL1B IL2 2146033 144011 Herein we present evidence that this subset of lymphocytes can synthesize IL-1 beta mRNA constitutively and that the cytoplasmic mRNA levels of [IL-1 beta] can be *increased* rapidly by . Positive_regulation IL1B IL2 2146033 144013 In addition , MAb to the p75 IL-2 receptor on LGL abrogated IL-2 induction of IL-1 beta mRNA , suggesting that signaling via the p75 IL-2 receptor *induced* [IL-1 beta] gene expression in LGL . Positive_regulation IL1B IL2 2440951 75824 These results indicate that the indirect effect of on hepatic acute phase protein synthesis is *mediated* by [IL 1-beta] . Positive_regulation IL1B IL2 2528591 117370 This response to IL-1 plus could be *induced* by IL-1 alpha or [IL-1 beta] and by membrane bound IL-1 on macrophages . Positive_regulation IL1B IL2 2584705 122232 *induction* of [IL-1 beta] mRNA expression in monocytes . Positive_regulation IL1B IL2 2584705 122233 In contrast , *induction* of [IL-1 beta] mRNA expression is blocked only by 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperazine , suggesting that PKc , and not CaM kinase , is activated by IL-2 . Positive_regulation IL1B IL2 3143761 101040 *stimulates* the production of IL-1 alpha and [IL-1 beta] by human peripheral blood mononuclear cells . Positive_regulation IL1B IL2 3143761 101044 In addition , Leu M3+ monocytes obtained through FACS , but not CD16+ NK cells , produced both IL-1 alpha and [IL-1 beta] in *response* to . Positive_regulation IL1B IL2 3263855 101286 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL2 7612386 312935 Immediately after PP , PBM production decreased and PBM [IL-1 beta] production *increased* . Positive_regulation IL1B IL2 7635420 317113 At 24 months , *induced* [IL-1 beta] synthesis was increased in patients treated with methotrexate , whereas S epidermidis induced IL-1 beta was enhanced in colchicine treated patients . Positive_regulation IL1B IL2 8495422 219509 These data suggest the interaction of and the high-affinity IL-2 receptor on human PBMC or peripheral blood lymphocyte is *required* for maximal secretion of [IL-1 beta] , TNF-alpha , TNF-beta , and IFN-gamma . Positive_regulation IL1B IL2 9300716 453881 Furthermore , anti-CD14 mAbs effectively inhibited the secretion of IL-8 and [IL-1beta] in *response* to . Positive_regulation IL1B IL2 9300716 453885 Expression of [IL-1beta] was also *augmented* by in U937/CD14 cells . Positive_regulation IL1B IL2 9351662 461190 [Interleukin-1beta (IL-1beta)] and interferon-gamma (IFN-gamma) *induced* similar effects on GDNF production , whereas and IL-6 had no significant effects . Positive_regulation IL1B IL2 9607578 508527 however , no effect on *induced* IL-8 induction , or on the [IL-1beta-] or IL-2 induced tumor necrosis factor production , was observed . Positive_regulation IL1B IL2 9657919 516885 [IL-1beta] and TNF-alpha synergistically *induced* IL-6 and GM-CSF and additively induced IL-8 and MCP-1 production , while , IL-10 , IFN-alpha , and IFN-gamma had little or no additional effects . Positive_regulation IL1B IL2 9681388 521068 mediated febrile responses in mice and [interleukin-1 beta] *activation* of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL20 16375968 1547148 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL20 17255956 1732950 gene expression is *induced* by [IL-1beta] through mitogen activated protein kinase and NF-kappaB dependent mechanisms . Positive_regulation IL1B IL20 18384650 1925550 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL20 18758357 1956627 In vitro , [IL-1beta] *induced* the expression of . Positive_regulation IL1B IL20 19342680 2056812 also *induced* production of [IL-1beta] , IL-8 , and MCP-1 in GBM8901 cells . Positive_regulation IL1B IL20 3263855 101287 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL20 9681388 521069 *mediated* febrile responses in mice and [interleukin-1 beta] activation of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL21 16375968 1547149 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL21 18384650 1925551 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL21 18512782 1922477 [IL-1beta] and IL-6 independently *induced* secretion , but the presence of IL-21 alone was not sufficient for IL-17 production . Positive_regulation IL1B IL21 3263855 101288 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL21 9681388 521070 mediated febrile responses in mice and [interleukin-1 beta] *activation* of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL22 16375968 1547132 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL22 18384650 1925534 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL22 3263855 101271 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL22 9681388 521052 *mediated* febrile responses in mice and [interleukin-1 beta] activation of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL23A 18164424 1875361 We also found that IL-17 was produced by microglia in *response* to or [IL-1beta] . Positive_regulation IL1B IL23A 18390747 1893329 IL-17A , IL-17F , and IL-23 could induce the release of chemokines GRO-alpha/CXCL1 , IL-8/CXCL8 , and MIP-1beta/CCL4 from eosinophils , while IL-17F and could also *increase* the production of proinflammatory cytokines [IL-1beta] and IL-6 . Positive_regulation IL1B IL24 16375968 1547130 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL24 18384650 1925532 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL24 3263855 101269 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL24 9681388 521050 *mediated* febrile responses in mice and [interleukin-1 beta] activation of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL25 16375968 1547131 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL25 18384650 1925533 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL25 3263855 101270 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL25 9681388 521051 mediated febrile responses in mice and [interleukin-1 beta] *activation* of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL26 16375968 1547136 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL26 18384650 1925538 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL26 23055831 2685185 Results show that *induces* the production of the proinflammatory cytokines [IL-1-beta] , IL-6 , and tumor necrosis factor (TNF)-alpha by human monocytes and also upregulates the expression of numerous chemokines ( mainly CCL20 ) . Positive_regulation IL1B IL26 3263855 101275 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL26 9681388 521056 *mediated* febrile responses in mice and [interleukin-1 beta] activation of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL27 16375968 1547137 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL27 18384650 1925539 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL27 3263855 101276 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL27 9681388 521057 mediated febrile responses in mice and [interleukin-1 beta] *activation* of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL3 1531845 180407 In particular , [IL-1 (-alpha and -beta)] , IL-2 , TNF (-alpha and -beta) , and IFN-gamma mRNA were readily *detected* , whereas , IL-4 , IL-5 , IL-6 , IL-7 , and granulocyte-macrophage colony stimulating factor mRNA were not detected , or were detectable only at very low levels . Positive_regulation IL1B IL3 1536949 180494 [Interleukin-1 beta (IL-1 beta)] expression in human blood mononuclear phagocytes is differentially *regulated* by granulocyte-macrophage colony stimulating factor ( GM-CSF ) , M-CSF , and . Positive_regulation IL1B IL3 16375968 1547150 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL3 18384650 1925552 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL3 3263855 101289 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL3 8862438 388667 Furthermore , [LIF+SCF+IL-1 beta] *induced* increased and GM-CSF mRNA expression in hematopoietic cells but induced decreased macrophage inflammatory protein 1 alpha ( MIP1 alpha ) mRNA expression as compared with SCF+IL-1 beta +IL-3 . Positive_regulation IL1B IL3 9681388 521071 *mediated* febrile responses in mice and [interleukin-1 beta] activation of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL31 16375968 1547138 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL31 18384650 1925540 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL31 3263855 101277 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL31 9681388 521058 *mediated* febrile responses in mice and [interleukin-1 beta] activation of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL32 16375968 1547135 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL32 18384650 1925537 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL32 3263855 101274 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL32 9681388 521055 mediated febrile responses in mice and [interleukin-1 beta] *activation* of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL33 16375968 1547134 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL33 18023358 1832123 In addition , also *induced* [IL-1beta] , TNF-alpha , MCP-1 , and PGD2 production in BMMC . Positive_regulation IL1B IL33 18023358 1832125 By RNase protection assay , we demonstrated that *increased* IL-6 and [IL-1beta] mRNA expression . Positive_regulation IL1B IL33 18384650 1925536 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL33 3263855 101273 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL33 9681388 521054 *mediated* febrile responses in mice and [interleukin-1 beta] activation of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL34 16375968 1547139 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL34 18384650 1925541 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL34 3263855 101278 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL34 9681388 521059 mediated febrile responses in mice and [interleukin-1 beta] *activation* of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL37 16375968 1547133 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL37 18384650 1925535 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL37 3263855 101272 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL37 9681388 521053 mediated febrile responses in mice and [interleukin-1 beta] *activation* of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL4 10088668 599958 and interleukin-10 *regulate* [IL1-beta] induced mouse primary astrocyte activation : a comparative study . Positive_regulation IL1B IL4 10692048 670704 In addition , and IL-10 neutralization did not *result* in enhanced [IL-1beta] production in Th2/monocyte co-cultures . Positive_regulation IL1B IL4 10720061 676805 IFNgamma , TNFalpha , [IL-1beta] , and IL-6 messenger RNA ( mRNA ) were mainly *detected* in EM tissue , whereas and IL-10 mRNA were detected in only one patient . Positive_regulation IL1B IL4 11477201 841981 thus , to further clarify the differences of monocyte function and differentiation between neonates and adults , we investigated their CD14 ( + ) CD4 ( + ) and CD14 ( + ) CD16 ( + ) monocyte subpopulations , production of [IL-1beta] and tumor necrosis factor-alpha induced by lipopolysaccharide , and their CD14 and CD1a phenotypic changes in *response* to and granulocyte-macrophage colony stimulating factor . Positive_regulation IL1B IL4 1533284 186441 alone ( 0.01-100 ng/ml ) did not *stimulate* [IL-1 beta] synthesis but rather induced IL-1ra ( 4.82 +/- 0.94 ng/ml ) . Positive_regulation IL1B IL4 16375968 1547151 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL4 18384650 1925553 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL4 2119829 141852 The reduced secretion of [IL-1 beta] and TNF alpha was specifically *induced* by because anti-IL-4 antiserum completely restored normal monokine production . Positive_regulation IL1B IL4 3263855 101290 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL4 7540642 310122 Seven-day cultured monocytes/macrophages showed ( 1 ) diminished TNF-alpha production in response to IL-10 but not IL-4 ( 2 ) , diminished [IL-1 beta] production in *response* to both and IL-10 , and compared with fresh monocytes ( 3 ) , diminished CD14 expression in response to IL-4 , and ( 4 ) a lesser increase in CD23 expression in response to IL-4 . Positive_regulation IL1B IL4 7882591 298877 The effect of is not *mediated* by quantitative modifications of class II and B7 molecule expression or of [IL-1 beta] production . Positive_regulation IL1B IL4 8260535 238829 In this study we investigated the effect of the T cell product interferon-gamma (IFN-gamma) on the glucocorticoid mediated and on the *mediated* inhibition of IL-1 beta mRNA and [IL-1 beta] protein synthesis in highly purified human monocytes . Positive_regulation IL1B IL4 8894439 392371 and IL-13 *increased* also [IL-1 beta] production by human microglial cells . Positive_regulation IL1B IL4 9505146 491287 [IL-1 beta] , and to a lesser extent , TNF-alpha and *increased* NEP activity and expression , whereas IFN-gamma decreased NEP . Positive_regulation IL1B IL4 9681388 521072 mediated febrile responses in mice and [interleukin-1 beta] *activation* of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL5 10725746 677671 *Activation* of HUVEC by [IL-1beta] or TNF-alpha or priming of eosinophils by both promote CCR3 dependent migration of eosinophils from the vasculature in conjunction with CCR3-active chemokines . Positive_regulation IL1B IL5 11988651 936346 Variances were noted depending on the type of fluid : HTD and LR solution did not induce expression of , and HTD also did not *induce* [IL-1beta] expression . Positive_regulation IL1B IL5 1531845 180408 In particular , [IL-1 (-alpha and -beta)] , IL-2 , TNF (-alpha and -beta) , and IFN-gamma mRNA were readily *detected* , whereas IL-3 , IL-4 , , IL-6 , IL-7 , and granulocyte-macrophage colony stimulating factor mRNA were not detected , or were detectable only at very low levels . Positive_regulation IL1B IL5 16375968 1547152 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL5 18384650 1925554 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL5 3263855 101291 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL5 9681388 521073 *mediated* febrile responses in mice and [interleukin-1 beta] activation of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL6 10391095 626198 In the conditioned medium , marked secretion was *induced* from WI-38 cells by [IL-1beta] or TNF-alpha . Positive_regulation IL1B IL6 10467171 640687 [Interleukin-1beta] *induces* production through the production of prostaglandin E ( 2 ) in human osteoblasts , MG-63 cells . Positive_regulation IL1B IL6 10564140 567134 The experiments demonstrate that LPS , TNF-alpha , [IL-1beta] , and IL-6 *induce* lowering of P ( if ) when given intravenously or intra-arterially , whereas only TNF-alpha , IL-1beta , and induce lowering of P ( if ) when given subdermally . Positive_regulation IL1B IL6 10623445 658047 In contrast , [IL-1beta] and IL-6 production by Mbeta from young males was suppressed and IL-10 production *enhanced* following trauma-haemorrhage , whereas Mstraight phi from aged males produced elevated levels of IL-1beta and and suppressed levels of IL-10 following trauma-haemorrhage . Positive_regulation IL1B IL6 10626139 576253 [Interleukin-1 beta] has potent OAF activity , can increase the expression of adhesion molecules , and can *induce* paracrine production ( see Fig. 1 ) . Positive_regulation IL1B IL6 10679106 668792 [IL-1 beta] *induced* the synthesis of , IL-8 , and matrix metalloproteinases (MMP)-1 and -3 . Positive_regulation IL1B IL6 10719060 676924 Similarly , and IFN-gamma potently *enhanced* [IL-1beta-] or TNF-alpha induced C3 and factor B secretion , respectively . Positive_regulation IL1B IL6 10807012 692156 [Interleukin-1beta] *induces* complement component C3 and production at the basolateral and apical membranes in a human intestinal epithelial cell line . Positive_regulation IL1B IL6 10821806 694645 In myocardium from control animals , neither TNF-alpha nor [IL-1beta] were *detected* , whereas was present at very low levels . Positive_regulation IL1B IL6 10878380 708975 Also , LPS induced both the [IL-1beta] and IL-6 genes in normocomplementemic mice , but in complement-deficient mice it significantly *induced* only . Positive_regulation IL1B IL6 11241162 791938 Lipopolysaccharide , [interleukin (IL)-1beta] , tumour necrosis factor (TNF)alpha and all significantly *increased* the expression of PBEF in 4 h of treatment . Positive_regulation IL1B IL6 11250916 793778 We hypothesized that [IL-1beta] and IL-6 induce OT receptor gene expression in human myometrial cells , and this is *mediated* by and cognate response elements in the 5'-flanking region of the OT receptor gene . Positive_regulation IL1B IL6 11268342 764499 [IL-1 beta] depresses peripheral immune responses , *induces* the production of plasma , and stimulates the HPA axis . Positive_regulation IL1B IL6 11554696 859899 [IL-1beta] significantly *induced* mRNA expression and protein secretion , which did not further enhance IL-1beta induced OT secretion . Positive_regulation IL1B IL6 11872267 918547 The production of TNF-alpha and was *induced* by [IL-1beta] and Abeta [ 25-35 ] and synergistically amplified by the co-stimulation of IL-1beta and Abeta [ 25-35 ] . Positive_regulation IL1B IL6 12188027 979948 TNF-alpha mRNA induction was maximum within 3 h , IL-6 mRNA was gradually induced up to 24 h , and [IL-1beta] and IL-12 mRNA were highly induced at 24 h . IL-1beta and protein levels also *increased* within 24 h in a dose dependent manner and reached a maximum with 100 microg/ml ginsan . Positive_regulation IL1B IL6 12190816 980013 [Interleukin-1 beta] *induces* mRNA expression and protein production in synovial cells from human temporomandibular joint . Positive_regulation IL1B IL6 12233876 988781 Androgen receptors in human synoviocytes and androgen regulation of [interleukin 1beta (IL-1beta)] *induced* production : a link between hypoandrogenicity and rheumatoid arthritis ? Positive_regulation IL1B IL6 12233876 988784 DHT exerts a suppressive effect on [IL-1beta] *induced* , macrophage-colony stimulating factor (CSF) , and granulocyte-CSF production by synoviocytes . Positive_regulation IL1B IL6 12421347 1013461 In comparison , [IL-1beta] *induced* the release of PGE2 , and activated NF-kappaB , p38 , JNK and ERK1/2 in mixed glial cultures , but failed to induce any of these responses in microglial cell cultures . Positive_regulation IL1B IL6 12568957 1057190 [IL-1 beta] *induces* COX2 , MMP-1 , -3 and -13 , ADAMTS-4 , IL-1 beta and in human tendon cells . Positive_regulation IL1B IL6 12569227 1057242 Plasma , IL-8 , IL-10 , granulocyte colony stimulating factor ( G-CSF ) , macrophage CSF (M-CSF) , and monocyte chemotactic protein 1 (MCP-1) increased significantly after the race , and urine [IL-1beta] , IL-6 , G-CSF , M-CSF , and MCP-1 *increased* significantly . Positive_regulation IL1B IL6 12668157 1075709 [IL-1beta] , however , *induced* a substantial increase in release in adipocytes and PBC ( all p < 0.05 ) . Positive_regulation IL1B IL6 12799018 1100964 [IL-1beta] *induced* release of and activated NFkappaB , p38 , JNK and ERK1/2 in mixed glial cultures , which was completely abolished in the presence of IL-1 receptor antagonist (IL-1ra) . Positive_regulation IL1B IL6 14572514 1155820 Infection *induced* [interleukin-1beta] gene expression in the hypothalamus , while and migration inhibitory factor mRNAs were induced only in the pituitary and adrenal glands . Positive_regulation IL1B IL6 14630536 1170466 Six hours after irradiation , [IL-1beta] levels had increased in the hypothalamus , thalamus and hippocampus , and TNFalpha and levels had *increased* significantly in the hypothalamus . Positive_regulation IL1B IL6 14659542 1177383 Pretreatment with anti-Toll-like receptor 2 (TLR2) antibody significantly inhibited [IL-1beta] , TNF-alpha and *induction* ( P < 0.05 ) in mouse macrophages and pit forming activity of osteoclast precursor cells stimulated with P. gingivalis 67-kDa minor fimbriae . Positive_regulation IL1B IL6 14662866 1177634 [IL-1beta] *induces* a > 10-fold up-regulation of NGAL expression in the type II pneumocyte derived cell line A549 cells , whereas TNF-alpha , , and LPS had no effect . Positive_regulation IL1B IL6 15076648 1233020 Twenty-four hours after exposure to 500 microg/m3 , nasal secretion levels of [IL-1beta] increased 72.3 % ( 0-150.2 % , P=0.002 ) , levels of *increased* 42.2 % ( -28-161.9 % , P=0.01 ) , and levels of IL-8 increased 19.7 % ( -20.3-60.5 % , P=0.03 ; median and 95 % confidence interval ) . Positive_regulation IL1B IL6 1527383 197553 Finally , [IL-1 beta] plus TNF-alpha *induced* the production of , but not of Ig , by adherent BM cells . Positive_regulation IL1B IL6 1527383 197557 These results suggest that [IL-1 beta] and TNF-alpha produced by adherent BM cells synergistically *induce* early generation , which , in turn , drives BM B cell producers into the high rate Ig-secreting state . Positive_regulation IL1B IL6 15455248 1374729 In the CSF , the [IL-1beta] level increased from 55.71+/-72.79 pg/ml at T1 to 106.10+/-142.12 pg/ml at T2 and the level *increased* from 405.43+/-280.28 pg/ml at T1 to 631.57+/-385.35 pg/ml at T2 ; Positive_regulation IL1B IL6 15655672 1375889 VSMCs were exposed to 44 degrees C for 15-60 min , and subjected to [interleukin-1beta (IL-1beta)] or tumor necrosis factor alpha (TNFalpha) , which *induced* production . Positive_regulation IL1B IL6 15731288 1439206 TNFalpha and [IL1beta] *induced* production by normal muscle samples and myoblasts , the action of TNFalpha being more potent on muscle samples . Positive_regulation IL1B IL6 15749024 1379449 Recombinant mouse [IL-1beta] *induced* strong activation of ERK1/2 , p38 , JNK and NFkappa B , and significant release of and PGE2 , which was blocked by IL-1ra . Positive_regulation IL1B IL6 15908350 1409453 In aortic valves and surrounding tissues , was detected by Western blots and immunostaining 24 h after GS-5 infection , was maintained over 72 h , and was *followed* by production of tumor necrosis factor alpha but not [IL-1beta] . Positive_regulation IL1B IL6 16000387 1447307 In the present study , incubation of AM with unopsonized Pneumocystis organisms was not associated with release of interleukin (IL)-1beta , , or tumor necrosis factor (TNF)-alpha ( important cytokines in the host response to Pneumocystis ) and did not *induce* [IL-1beta] , IL-6 , or TNF-alpha mRNA transcripts . Positive_regulation IL1B IL6 16002736 1431017 [IL-1 beta] *induces* expression in human orbital fibroblasts : identification of an anatomic-site specific phenotypic attribute relevant to thyroid associated ophthalmopathy . Positive_regulation IL1B IL6 16175346 1461822 TNF-alpha and [IL-1beta] are early regulators of the immune response and both *induce* the release of secondary cytokines , such as and IL-8 . Positive_regulation IL1B IL6 16198622 1496326 Although [IL-1beta] *induces* production in hepatocytes , our data indicate that the effect of IL-1beta on hepcidin expression is independent from that of IL-6 . Positive_regulation IL1B IL6 16375968 1547153 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL6 16399630 1513043 These results suggest that CHL *inhibits* [IL-1beta] production in macrophages stimulated with LPS at transcriptional level by blocking the phosphorylation of p38 and by suppressing the activation of transcription factors , NF-kappaB , , and AP-1 . Positive_regulation IL1B IL6 16413378 1513956 TNF-alpha and [IL-1beta] ( 0.01 to 100 ng/mL ) *induced* secretion of IL-8 , , and RANTES in a dose and time dependent manner . Positive_regulation IL1B IL6 16616208 1582991 The expression of and IL-11 *increased* greatly in the presence of [IL-1beta] on day 1 and after day 14 of culture . Positive_regulation IL1B IL6 1675538 158018 These results demonstrate that enhancement of keratinocyte bound does not *induce* TNF alpha , [IL-1 alpha/beta] or IL-6 expression by LC during APR or IPR , and that enhanced keratinocyte expression of IL-6 fails to distinguish between these two reactions . Positive_regulation IL1B IL6 17005253 1666312 In contrast , both [IL-1beta] and TNFalpha highly *induced* secretion in chorion derived cells , demonstrating the overall responsiveness of these cells to these stimuli . Positive_regulation IL1B IL6 17024100 1674280 Induction of IL-6 by [IL-1beta] peptide and *stimulation* by peptide in NFs , or inhibition of IL-6 or IL-6R alpha in KFs cultures demonstrated a dose dependent increase or decrease in procollagen I synthesis , respectively . Positive_regulation IL1B IL6 1702762 151306 Neutralization assays using antisera to human interleukin-1 alpha ( HuIL-1 alpha ) , HuIL-1 beta , and HuIL-6 revealed that cell-free TAF was attributable mainly to IL-1 beta and that *augmented* the TAF activity of [IL-1 beta] in the culture supernatant . Positive_regulation IL1B IL6 17201586 1663170 Exogenous [IL-1beta] *induces* its own expression , but not that of in the hypothalamus and activates HPA axis and prolactin release . Positive_regulation IL1B IL6 17320940 1719785 FCAS monocytes respond to mild hypothermia with [IL-1beta] release , which in turn *induces* autocrine transcription and secretion of and TNF-alpha as well as stimulation of further IL-1beta production . Positive_regulation IL1B IL6 17881510 1823680 We found that IL-33 , but not [IL-1beta] or IL-18 , *induced* IL-13 and production by mouse bone marrow derived , cultured mast cells ( BMCMCs ) independently of IgE . Positive_regulation IL1B IL6 18214991 1895512 We show that CNTF reduces COX-2 levels , whereas *increases* the expression of [IL-1beta] , TNFalpha , and Cox-2 . Positive_regulation IL1B IL6 18313744 1879831 Experiments employing neutralising antibodies indicate that exposure of co-cultured macrophages to both Ti-based particles *induces* the release of M-CSF , GM-CSF , and PGE2 through up-regulation of [IL-1beta] and TNF-alpha . Positive_regulation IL1B IL6 18384650 1925555 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL6 18434191 1920800 Here we demonstrate that , whilst [IL-1beta] *induced* significant synthesis of in neurones , IL-1alpha had no effect . Positive_regulation IL1B IL6 19012188 1991683 Tumor necrosis factor-alpha , [interleukin (IL)- 1beta] , and *increased* significantly in both groups . Positive_regulation IL1B IL6 19117935 2060757 [IL-1beta] also *induced* MCP-1 , , and IL-8 more vigorously in TAO derived fibroblasts . Positive_regulation IL1B IL6 2012180 156668 [Interleukin-1 beta] and tumor necrosis factor-alpha *induce* gene expression and production of leukocyte chemotactic factors , colony stimulating factors , and in human mesangial cells . Positive_regulation IL1B IL6 20403707 2282297 [IL-1beta] as well as IL-6+sIL-6R *induced* production . Positive_regulation IL1B IL6 20419825 2246675 On day 1 after infection , the secretion of both TNF-alpha and decreased significantly in the bronchoalveolar lavage fluid prepared from RSV infected offspring exposed to DBDE perinatally , but [IL-1beta] *increased* . Positive_regulation IL1B IL6 21398280 2431940 [Interleukin-1beta] *increases* baseline expression and secretion of by human uveal melanocytes in vitro via the p38 MAPK/NF-kappaB pathway . Positive_regulation IL1B IL6 2203522 140652 while could be *induced* by both [IL-1 beta] and tumor necrosis factor-alpha . Positive_regulation IL1B IL6 2265243 147224 We found that [IL-1 beta] *induced* messenger RNA expression in elutriated monocytes and IL-6 secretion in the supernatant . Positive_regulation IL1B IL6 2294996 127514 did not *stimulate* [IL-1 beta] or TNF production , but suppressed IL-1 beta and TNF production induced by LPS or PHA by 30 % ( P less than .01 ) . Positive_regulation IL1B IL6 24279177 2876956 In non-gravid pigs [IL1beta] , and TNFalpha *increased* endometrial E1 release only on days 12 to 13 of the estrous cycle . Positive_regulation IL1B IL6 2805453 121246 The ability of Escherichia coli derived lipopolysaccharide (LPS) , recombinant ( r ) [interleukin 1-beta] ( rIL-1 beta ) , and r murine tumor necrosis factor-alpha ( rMuTNF-alpha ) to *induce* production in vivo was investigated . Positive_regulation IL1B IL6 3263855 101292 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL6 7597700 311306 The abundance of mRNAs for several cytokines was increased in VT-exposed mice with maximal effects occurring in the 25 mg/kg group at 2 hr. Specifically , [IL-1 beta] and mRNA levels *increased* in spleen and PP following exposure to VT . Positive_regulation IL1B IL6 7751003 306741 Both TGF-beta and [IL-1 beta] alone *induce* IL-6 mRNA and production in human RPE cells and synergize to enhance IL-6 mRNA levels and IL-6 production over a range of TGF-beta ( 0.1-10 ng/ml ) and IL-1 beta concentrations ( 5-500 U/ml ) . Positive_regulation IL1B IL6 7814800 285249 Furthermore , lipopolysaccharide , tumor necrosis factor-alpha , interferon-gamma , [interleukin-1 beta] and phorbol ester *induced* production and , at the same time , suppressed the level of interleukin-6 receptor mRNA . Positive_regulation IL1B IL6 7962300 279368 Plasma IL-1 beta and tumor necrosis factor-alpha concentrations , assayed by specific enzyme linked immunosorbent assays during the 4 h after the first IL-6 injection , were either within the normal range or undetectable , confirming in vitro observations that does not *stimulate* [IL-1 beta] or tumor necrosis factor-alpha secretion and suggesting that it exerts its effect on the HPA axis and AVP secretion independently of them . Positive_regulation IL1B IL6 8008165 258480 [Interleukin-1 beta] has been shown to be synthesized in small amounts by astrocytes and can *induce* the expression of . Positive_regulation IL1B IL6 8040328 266672 gene expression and IL-6 secretion by A549 cells was *induced* by [IL-1 beta] , TNF alpha , and by human alveolar macrophages and THP1 cells CM. Induction was abolished when CM were preincubated with anti-IL-1 beta and anti-TNF alpha antibody . Positive_regulation IL1B IL6 8413826 233940 secretion was *induced* by [IL-1 beta] in a concentration as low as 1 x 10 ( -10 ) M ( p = 0.0008 ) ; Positive_regulation IL1B IL6 8543919 338856 However , when added to the cells during days 6-9 of culture , when most of the cells were syncytiotrophoblast cells , *stimulated* IL-1 alpha and [IL-1 beta] mRNA expression . Positive_regulation IL1B IL6 8609408 352813 Moreover , in agonist activated macrophages , supernatants from Brucella cultures promoted an inhibition of the induction of both TNF-alpha expression and release , without affecting [IL-1 beta] or *induction* . Positive_regulation IL1B IL6 8780161 380050 After 24 hours , contact allergens not only increased the expression of [IL-1 beta] but also *induced* the expression of IL-1 alpha , TNF-alpha , GM-CSF , and proteins mainly by suprabasal keratinocytes . Positive_regulation IL1B IL6 8931762 397882 In the presence of LPS and CPA , however , [IL-1 beta] and mRNA levels gradually *increased* up to 24 h reaching 2.5 and 29-fold higher than controls , respectively . Positive_regulation IL1B IL6 8980876 403750 If added to cells activated by interferon gamma and lipopolysaccharide , radicicol analogue A not only inhibited the secretion of [IL-1 beta] but also *induced* an extremely rapid degradation of IL-1 beta , and TNF-alpha mRNA to undetectable levels within 5-8 h . Positive_regulation IL1B IL6 9013944 411823 Thus , IFN-gamma and [IL-1beta] levels were *increased* 13-fold and 30-fold , respectively , with more modest increases in levels ( 5-fold ) and TNF levels ( 2-fold ) . Positive_regulation IL1B IL6 9309381 454743 release and resorption ( 45Ca release ) were *induced* by [IL 1 beta] in neonatal mouse calvaria bones in culture . Positive_regulation IL1B IL6 9316474 456176 In addition , [IL-1 beta] , IL-6 , and TNF-alpha mRNAs were rapidly ( 7 h ) upregulated in the pancreas , and intrapancreatic IL-1 beta and protein levels rapidly *increased* ( 3-fold and 6.4-fold , respectively ) during acute pancreatitis . Positive_regulation IL1B IL6 9329125 457453 Treatment of the Caco-2 cells with [IL-1 beta] *induced* expression of IL-6 mRNA with a response noticed after 30 min . TNF-alpha and did not influence the production of IL-6 in the Caco-2 cells . Positive_regulation IL1B IL6 9351662 461191 [Interleukin-1beta (IL-1beta)] and interferon-gamma (IFN-gamma) *induced* similar effects on GDNF production , whereas IL-2 and had no significant effects . Positive_regulation IL1B IL6 9572400 501801 On the other hand , there was no change in serum levels of [IL-1beta] and IL-8 , and the serum levels of IL-1ra and even *increased* at the end of a single PE , in spite of high levels of all cytokines and adhesion molecules in the plasma filtrate . Positive_regulation IL1B IL6 9626137 511768 did not *stimulate* secretion of [IL-1 beta] in the 7 cultures tested . Positive_regulation IL1B IL6 9681388 521074 *mediated* febrile responses in mice and [interleukin-1 beta] activation of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL6 9792466 542540 We observed that ( 1 ) [IL-1beta] and TNFalpha *induced* in a dose and time dependent fashion , ( 2 ) TGFbeta 1 and 2 enhanced basal and IL-1beta and TNFalpha induced IL-6 expression , ( 3 ) ET-1 elicited a dose dependent stimulatory effect on IL-6 expression . Positive_regulation IL1B IL6 9873234 583484 Moreover Am-80 inhibited [IL-1beta] *induced* production and IL-6 mRNA expression in human osteoblast-like cells ( MG-63 ) . Positive_regulation IL1B IL6 9878816 583804 The *role* of in the activation of the hypothalamo-pituitary-adrenocortical axis and brain indoleamines by endotoxin and [interleukin-1 beta] . Positive_regulation IL1B IL7 1531845 180409 In particular , [IL-1 (-alpha and -beta)] , IL-2 , TNF (-alpha and -beta) , and IFN-gamma mRNA were readily *detected* , whereas IL-3 , IL-4 , IL-5 , IL-6 , , and granulocyte-macrophage colony stimulating factor mRNA were not detected , or were detectable only at very low levels . Positive_regulation IL1B IL7 16375968 1547154 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL7 18384650 1925556 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL7 2007858 154855 In addition to promoting IL-6 production , *induced* the secretion of immunoreactive IL-1 alpha , [IL-1 beta] , and tumor necrosis factor alpha (TNF-alpha) by monocytes . Positive_regulation IL1B IL7 3263855 101293 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL7 9681388 521075 mediated febrile responses in mice and [interleukin-1 beta] *activation* of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL8 10226066 610333 Release of [IL-1beta] in the airway microenvironment *induces* the production of proinflammatory factors from parenchymal airway cells , including . Positive_regulation IL1B IL8 10372996 622135 [IL-1beta] and TNF-alpha *induced* dose dependent increases in HRPE and MCP-1 secretion with maximal stimulation observed at 2-5 ng/ml . IL-4 alone ( 100 ng/ml ) resulted in a slight increase of MCP-1 and IL-8 secretion . Positive_regulation IL1B IL8 10580798 570122 However , 100 u/ml [IL-1beta] *induced* greater stimulation of both and MCP-1 secretion in HCEC ( 50 and 20 times above controls , respectively ) than in FHAS ( three and two times above controls , respectively ) . Positive_regulation IL1B IL8 10707928 673448 [IL-1beta] and tumor necrosis factor (TNF)-alpha both *induced* a marked increase in C3 and secretion . Positive_regulation IL1B IL8 10741905 680028 Both IL-1alpha and [IL-1beta] *induced* ICAM-1 expression and and MCP-1 production at lower doses than TNF alpha or TNF beta . Positive_regulation IL1B IL8 11285034 799724 Further , the treatment of endometrial carcinoma cells with inflammatory cytokines , IL-1beta and tumor necrosis factor-alpha (TNF-alpha) , demonstrated that [IL-1beta] and TNF-alpha *induced* expression in endometrial cancer cells . Positive_regulation IL1B IL8 11676825 873538 In interleukin-1beta transfected human dermal fibroblasts , was *induced* through an autocrine activity of [interleukin-1beta] . Positive_regulation IL1B IL8 11989790 936375 [IL-1 beta] *induced* the maximum release of ( 800-fold ) and MCP-1 ( 164-fold ) , as compared to the controls . Positive_regulation IL1B IL8 12379764 997315 GROalpha does not seem to initiate TNFalpha , [IL-1beta] , and IL-8 in an early phase , but *induces* IL-1beta and in a late phase . Positive_regulation IL1B IL8 12753503 1090313 Tumour necrosis factor-alpha (TNF-alpha) and [IL-1beta] *induced* mesothelial cell mRNA expression , and neutralizing anti-TNF-alpha antibody and IL-1 receptor antagonist nearly completely obliterated CoMTB induced mesothelial cell IL-8 mRNA expression and protein secretion . Positive_regulation IL1B IL8 12792762 1097868 Conversely , IL-1alpha and [IL-1beta] , *induced* a 5- to 104-fold stimulation of BEC and a 330 to 1,138-fold increase in expression in estrogen independent BCC . Positive_regulation IL1B IL8 12912854 1129489 Comparable secretory responses ( approximately 1700 ng/ml ) measured by ELISA were *induced* by 2.0 ng/ml [IL-1beta] and by H pylori at a multiplicity of infection ( MOI ) of 50 . Positive_regulation IL1B IL8 15001224 1217049 [IL-1beta] and TNF-alpha mRNA , but not protein , were increased , and secretion *increased* without an observed increase in mRNA . Positive_regulation IL1B IL8 15076648 1233021 Twenty-four hours after exposure to 500 microg/m3 , nasal secretion levels of [IL-1beta] increased 72.3 % ( 0-150.2 % , P=0.002 ) , levels of IL-6 increased 42.2 % ( -28-161.9 % , P=0.01 ) , and levels of *increased* 19.7 % ( -20.3-60.5 % , P=0.03 ; median and 95 % confidence interval ) . Positive_regulation IL1B IL8 15939312 1415504 [IL-1beta] *induces* in bronchial cells via NF-kappaB and NF-IL6 transcription factors and can be suppressed by glucocorticoids . Positive_regulation IL1B IL8 16175346 1461823 TNF-alpha and [IL-1beta] are early regulators of the immune response and both *induce* the release of secondary cytokines , such as IL-6 and . Positive_regulation IL1B IL8 16375968 1547155 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL8 16413378 1513957 TNF-alpha and [IL-1beta] ( 0.01 to 100 ng/mL ) *induced* secretion of , IL-6 , and RANTES in a dose and time dependent manner . Positive_regulation IL1B IL8 16616208 1582987 The expression of IL-1beta , , and TNF-alpha markedly *increased* in the presence of [IL-1beta] after day 14 of culture . Positive_regulation IL1B IL8 17122965 1652783 HPE and [IL-1beta] *induced* a significant increase in production by MKN45 and HUVEC , respectively , along with NFkappaB activation , which was significantly inhibited by PPI . Positive_regulation IL1B IL8 1729366 180969 By using a specific RIA , we demonstrate that not only [IL-1 beta] , but also TNF-alpha and LPS can *induce* abundant secretion from chondrocytes . Positive_regulation IL1B IL8 17700564 1794527 IL-33 or [IL-1beta] also *induced* and IL-13 production in naïve HUCBMCs , and enhanced production of these cytokines in IgE/anti-IgE stimulated HUCBMCs , without enhancing secretion of either PGD ( 2 ) or histamine . Positive_regulation IL1B IL8 18354287 1887637 *increased* sharply in the first 6.5 hours postexposure ( P < .001 ) , and [IL-1beta] in the first 6.1 hours ( P < .001 ) . Positive_regulation IL1B IL8 18384650 1925557 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL8 18547319 1952256 In vitro , both leptin and resistin could induce and tumour necrosis factor-alpha production by blood monocytes , and leptin could additionally *induce* [IL-1beta] and IL-1 receptor antagonist production . Positive_regulation IL1B IL8 18787030 2012208 We previously reported that [IL-1beta] *induced* production in human endometrial stromal cells ( ESCs ) and that induction was regulated by substances implicated in implantation . Positive_regulation IL1B IL8 19117935 2060758 [IL-1beta] also *induced* MCP-1 , IL-6 , and more vigorously in TAO derived fibroblasts . Positive_regulation IL1B IL8 19594487 2105405 TNF-alpha seems to induce preferably the expression of RANTES , MCP-1 , interferon-inducible protein ( IP-10 ) and Interferon-Inducible T-cell Alpha Chemoattractant ( I-TAC ) , while [IL-1beta] *induces* mainly and epithelial neutrophil activating peptide 78 ( ENA-78 ) . Positive_regulation IL1B IL8 20478455 2263042 [IL-1beta] and IL-6 simultaneously *induced* and monocyte chemoattractant protein-1 secretion in PDL cells , whereas SOCS-3 overexpression suppressed secretion of these chemokines through inhibition of phosphorylation in downstream signaling . Positive_regulation IL1B IL8 3263855 101294 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL8 7875467 298279 TNF-alpha and [IL-1 beta] dose-dependently *induced* production in HT-29 cells . Positive_regulation IL1B IL8 8274477 247106 Marked induction by Ox-LDL did not *require* [IL-1 beta] generation in THP-1 cells . Positive_regulation IL1B IL8 8544101 338863 IL-1 beta activation of GF cells showed that [IL-1 beta] non only *induces* the expression of IL-6 , and TNF-alpha , but also acts in an autocrine manner of GF cells and induces IL-1 beta expression . Positive_regulation IL1B IL8 8987336 404127 Interleukin-1 alpha , [interleukin-1 beta] and levels rose significantly as the concentrations of granulocyte elastase *increased* . Positive_regulation IL1B IL8 9165668 432292 Similar to what was observed during normoxia , TNF-alpha , [IL-1 beta] , and *increased* PMN bactericidal activity during hypoxia compared with buffer control PMN for S. aureus but not E. coli after 4 h of hypoxia . Positive_regulation IL1B IL8 9166282 432339 These results provide new evidence that as well as TNF alpha are the most proximal cytokines and *induce* subsequent production of [IL-1 beta] and IL-1Ra . Positive_regulation IL1B IL8 9427069 472691 Administration of TNF alpha or [IL-1 beta] *induced* production ; Positive_regulation IL1B IL8 9558101 500048 These data suggest that targeted deposits of IgG can stimulate FcgammaRIII bearing lymphocytes to produce [IL-1beta] , which *induces* parenchymal cell release . Positive_regulation IL1B IL8 9586676 504543 As anticipated , [IL-1beta] *induced* a marked release of collagenase , stromelysin , IL-6 , and PGE2 . Positive_regulation IL1B IL8 9611001 508911 [Interleukin-1beta] *induced* a significant increase in secretion by fibroblasts in vitro , from 0.8 ng/10 ( 6 ) cells to 35.6 ng/10 ( 6 ) cells . Positive_regulation IL1B IL8 9657919 516886 [IL-1beta] and TNF-alpha synergistically *induced* IL-6 and GM-CSF and additively induced and MCP-1 production , while IL-2 , IL-10 , IFN-alpha , and IFN-gamma had little or no additional effects . Positive_regulation IL1B IL8 9681388 521076 *mediated* febrile responses in mice and [interleukin-1 beta] activation of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B IL8 9893037 558644 [IL-1beta] and TNF-alpha *induced* the synthesis of at 24 hr , but partially inhibited the synthesis at 48 hr . Positive_regulation IL1B IL9 16375968 1547156 These results suggest that the central *activation* of receptors by [IL-1beta] is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL1B IL9 18384650 1925558 Potentiation of AMPA toxicity was prevented when [IL-1beta] production or its receptor signaling were *blocked* by an inhibitor of or IL-1 receptor antagonist during application of LPS + ATP . Positive_regulation IL1B IL9 3263855 101295 The ability of the two forms of , IL-1 alpha and IL-1 beta , to *induce* [IL-1 beta] gene expression in human skin fibroblasts was studied in vitro , using Northern blot hybridization . Positive_regulation IL1B IL9 9681388 521077 mediated febrile responses in mice and [interleukin-1 beta] *activation* of NFkappaB in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B INHBA 1417851 201706 In a human bone marrow derived stromal cell line , KM-102 , phorbol myristate acetate , tumor necrosis factor-alpha and [interleukin-1 beta] *induced* great increases in beta A chain mRNA levels and production of activities . Positive_regulation IL1B INHBA 19403063 2070395 Our data revealed that could not only *increase* [IL-1 beta] and IL-6 production from RAW264.7 cells , but also promote pinocytic and phagocytic activities of RAW264.7 cells . Positive_regulation IL1B INHBA 19887052 2161251 In the present study , the results showed that not only *increased* NO and [IL-1beta] release , but also promoted phagocytic abilities of mouse peritoneal macrophages in vitro and in vivo , whereas it did not influence MHC I and MHC II expression . Positive_regulation IL1B INHBA 9712365 527255 *regulates* the production of mature [interleukin-1beta] and interleukin-1 receptor antagonist in human monocytic cells . Positive_regulation IL1B INHBA 9712365 527262 Northern blot analysis revealed that activin A had no effect on mRNA accumulation of IL-1beta and IL-1ra , indicating that *regulates* [IL-1beta] and IL-1ra production at a posttranscriptional level . Positive_regulation IL1B INMT 19134459 2025399 Compared with the blank control group , [IL-1beta] might *induce* , which was showed in increasing expression of alpha-SMA , increasing secreting of FN and decreasing expression of E-cadherin , and at the same time the expressions of TGF-beta1 and ILK were enhanced ( P < 0.05 ) . Positive_regulation IL1B INS 1487310 208358 Selective *enhancement* of [interleukin 1 beta] production in myelomonocytic cell lines by and its related cytokines . Positive_regulation IL1B INS 1487310 208359 itself did not *stimulate* [IL-1 beta] production directly , but increased it in the mitogen activated cells . Positive_regulation IL1B INS 16023781 1441612 In iNOS-/- islets , [IL-1beta] at high glucose *induced* a delayed and prolonged stimulation of secretion , and this was followed by an increase in phospholipase D mRNA expression . Positive_regulation IL1B INS 2137789 128803 In the short-term , [IL-1 beta] *induced* a dosage dependent stimulation of release . Positive_regulation IL1B INS 2687062 122638 Human [interleukin-1 beta] *induced* stimulation of release from rat pancreatic islets is accompanied by an increase in mitochondrial oxidative events . Positive_regulation IL1B INS 7531672 286087 Hsp 73 concentrations also increased following treatment with conditioned media and [IL-1 beta] in the *presence* or absence of . Positive_regulation IL1B IRAK1 11583588 865686 To study the *role* of in [IL-1 beta] signalling , we have generated a set of IRAK-1 variants that express distinct domains of IRAK-1 either alone or in combination and have examined their effects on an NF-kappa B-responsive reporter in HeLa cells . Positive_regulation IL1B IRAK1 11698503 878207 However , neither TNF-alpha nor [IL-1beta] *induced* degradation or stimulated TNF-alpha or TxB2 production in naive cells . Positive_regulation IL1B IRAK1 19342688 2056848 The *role* and relative contribution of MyD88 , , and TRAF6 adaptor proteins in [IL-1beta] regulation of aggrecanase-1 ( ADAMTS-4 ) is unknown . Positive_regulation IL1B IRAK2 11698503 878208 However , neither TNF-alpha nor [IL-1beta] *induced* degradation or stimulated TNF-alpha or TxB2 production in naive cells . Positive_regulation IL1B IRAK3 11698503 878205 However , neither TNF-alpha nor [IL-1beta] *induced* degradation or stimulated TNF-alpha or TxB2 production in naive cells . Positive_regulation IL1B IRAK4 11277982 798049 In summary , we demonstrate that [IL-1beta] induction of NPY expression in astrocytes is species- and cytokine-specific and that is *involved* . Positive_regulation IL1B IRAK4 11698503 878206 However , neither TNF-alpha nor [IL-1beta] *induced* degradation or stimulated TNF-alpha or TxB2 production in naive cells . Positive_regulation IL1B IRAK4 15483191 1354717 TNF receptor p55 (TNFRp55) and type I ( IL-1RI ) *mediate* the biological functions of TNF-alpha and [IL-1beta] , respectively . Positive_regulation IL1B IRAK4 19853379 2165443 Using this model we observed that : ( 1 ) inflammasome components and products NALP1 , caspase-1 , IL-1beta and IL-18 were present in low levels in normal skin , but expression of all these was strongly up-regulated after fracture , ( 2 ) NALP1 , caspase-1 and IL-1beta were co-expressed in keratinocytes , and the number of NALP1 , caspase-1 , and IL-1beta positive cells dramatically increased at 4 weeks post-fracture , ( 3 ) LY303870 , an NK1 receptor antagonist , effectively blocked fracture induced up-regulation of activated inflammasome components and cytokines , ( 4 ) [IL-1beta] and IL-18 intraplantar injection *induced* mechanical allodynia in normal rats , and ( 5 ) both a selective caspase-1 inhibitor and an antagonist attenuated fracture induced hindpaw mechanical allodynia . Positive_regulation IL1B IRAK4 7878046 298811 These observations suggest that the type II sIL-1R *inhibits* [IL-1 beta] at two steps , by preventing processing of propeptide and by blocking the interaction of mature IL-1 beta with type I . Positive_regulation IL1B IRF1 11742807 897778 Conversely , IFN-gamma , but not [IL-1 beta] , *induced* signal transducer and activator of transcription ( STAT ) 1 and binding . Positive_regulation IL1B IRF1 19843519 2170105 is also *induced* by [IL-1beta] and binds to a different element upstream in the promoter . Positive_regulation IL1B IRF1 9202213 439969 [IL-1beta] alone *induced* a marginal and transient increase in . Positive_regulation IL1B IRF4 10453013 637883 Furthermore , both and ICSBP *activated* transcription of the [IL-1beta] promoter in both cell types . Positive_regulation IL1B IRF4 11359842 816411 In macrophages , synergistic activation of [IL-1beta] reporter gene expression was preferentially *mediated* by , whereas IRF-4 and ICSBP were equally capable of synergizing with PU.1 when coexpressed in fibroblasts . Positive_regulation IL1B IRF4 11359842 816417 Furthermore , coexpression of IRF-1 and IRF-2 dramatically increased the capacity of both and PU.1/ICSBP to *induce* [IL-1beta] reporter gene expression in fibroblasts . Positive_regulation IL1B IRF7 15749911 1379790 We now show , using real-time PCR , that in astrocytes [IL-1beta] *induces* the expression of IFN-beta , , CXCL10/IFN-gamma-inducible protein-10 , and CCL5/RANTES . Positive_regulation IL1B IRF8 10453013 637882 Furthermore , both IRF4 and *activated* transcription of the [IL-1beta] promoter in both cell types . Positive_regulation IL1B IRF8 11359842 816416 Furthermore , coexpression of IRF-1 and IRF-2 dramatically increased the capacity of both PU.1/IRF-4 and to *induce* [IL-1beta] reporter gene expression in fibroblasts . Positive_regulation IL1B IRF8 17386941 1735543 Phosphorylation of in a pre associated complex with Spi-1/PU.1 and non phosphorylated Stat1 is *critical* for LPS induction of the [IL1B] gene . Positive_regulation IL1B ISG15 20660068 2311011 We hypothesized that ISG15 depletion ( Isg15 ( -/- ) ) alters decidual tissue gene expression and that [IL-1beta] *induces* expression and isgylation in cultured murine decidual explants and human uterine fibroblasts ( HuFs ) . Positive_regulation IL1B ITGA4 10669630 665773 Experiments with blocking antibodies demonstrated that binding of monocyte to endothelial vascular cell adhesion molecule-1 ( VCAM-1 ) was *necessary* for the induction of [IL-1beta] in monocytes . Positive_regulation IL1B ITGAM 10845922 700724 Engagement of and CD11c beta2 integrin by antibodies or soluble CD23 *induces* [IL-1beta] production on primary human monocytes through mitogen activated protein kinase dependent pathways . Positive_regulation IL1B ITGAM 11698472 878076 [IL-1beta] also *induced* O ( 2 ) ( - ) release and up-regulation of and CD15 , and both responses were inhibited by SB203580 ( p38 MAPK inhibitor ) , suggesting that p38 MAPK activation mediates IL-1beta induced O ( 2 ) ( - ) release and up-regulation of CD11b and CD15 . Positive_regulation IL1B ITGAM 7836771 293746 We show that induction of [IL-1 beta] by fibrin is *mediated* partly by the integrin receptor and modulated by cytoskeletal rearrangement . Positive_regulation IL1B ITGAX 10845922 700725 Engagement of CD11b and beta2 integrin by antibodies or soluble CD23 *induces* [IL-1beta] production on primary human monocytes through mitogen activated protein kinase dependent pathways . Positive_regulation IL1B ITGB1 10669630 665774 Experiments with blocking antibodies demonstrated that binding of monocyte to endothelial vascular cell adhesion molecule-1 ( VCAM-1 ) was *necessary* for the induction of [IL-1beta] in monocytes . Positive_regulation IL1B ITGB2 17332440 1747956 Peptidoglycan ( PGN ) ( TLR2 ligand ) , flagellin ( TLR5 ligand ) , and Imiquimod R837 ( TLR7 ligand ) could significantly upregulate cell surface expression of intercellular adhesion molecule (ICAM)-1 and , and *induce* the release of [IL-1beta] , IL-6 , IL-8 , growth related oncogene ( GRO ) -alpha , and superoxides of eosinophils . Positive_regulation IL1B ITGB2 7836771 293747 We show that induction of [IL-1 beta] by fibrin is *mediated* partly by the integrin receptor and modulated by cytoskeletal rearrangement . Positive_regulation IL1B ITIH4 10751560 681628 This is because activates brain microglial cells and astrocytes , and in vivo activation of glia *leads* to the release of the proinflammatory cytokine [interleukin-1 beta (IL-1beta)] . Positive_regulation IL1B ITIH4 11704656 879375 HIV-1 coat protein *stimulates* [interleukin-1beta] secretion from human neuroblastoma cells : evidence for a role in the mechanism of cell death . Positive_regulation IL1B ITIH4 16989980 1746970 These studies demonstrate that : ( a ) intrathecal upregulates meningeal gene expression of proinflammatory signals , including tumor necrosis factor-alpha (TNF-alpha) , interleukin-1beta (IL-1beta) , interleukin 6 (IL-6) , and inducible nitric oxide synthase (iNOS) , and ( b ) intrathecal gp120 *induces* meningeal release of TNF-alpha , [IL-1beta] , and IL-6 . Positive_regulation IL1B ITIH4 16989980 1746973 In addition , stimulation of isolated meninges in vitro with *induced* the release of TNF-alpha and [IL-1beta] , indicating that the resident cells of the meninges are able to respond without immune cell recruitment . Positive_regulation IL1B ITIH4 18453587 1909116 In this study we showed that *induces* [IL-1beta] release from macrophages in a time- and concentration dependent manner through binding to the chemokine receptor CCR5 and coupling to G ( i ) alpha protein . Positive_regulation IL1B ITIH4 18453587 1909117 Using pharmacological inhibitors and small interfering RNA gene knockdown , we demonstrated that concomitant activation of Lyn , Pyk2 , and class IA PI3K are required for *induced* [IL-1beta] production . Positive_regulation IL1B ITIH4 20353818 2281954 A second alpha7nAchR agonist , GTS-21 , also significantly reversed *induced* mechanical allodynia and lumbar spinal cord levels of pro-inflammatory cytokine mRNAs and [IL-1beta] protein . Positive_regulation IL1B ITIH4 2335821 133762 Our studies indicate that , in the absence of endotoxin , HIV-1 , HIV-2 , and HIV do not *induce* production of [IL-1 beta] , IL-6 , or TNF-alpha by peripheral blood mononuclear cells . Positive_regulation IL1B ITIH4 9070311 419203 *increased* [IL-1 beta] , IL-1Ra , TNF-alpha , and TGF-beta 1 mRNAs . Positive_regulation IL1B ITIH4 9700761 525259 In separate experiments on normal peripheral blood mononuclear cells ( PBMC ) , alpha-MSH ( 1-13 ) inhibited production of [IL-1 beta] and TNF alpha *induced* by HIV envelope glycoprotein . Positive_regulation IL1B JAG1 12912854 1129491 The same [IL-1beta] and H pylori concentrations *induced* comparable increases in cell caseinolytic activity at 60 kDa . Positive_regulation IL1B JAK1 16934228 1639079 In the present study , we investigated whether the activation of signaling *mediates* [IL-1beta] expression in pancreatic acinar AR42J cells stimulated with cerulein in vitro as well as the rats with cerulein pancreatitis in vivo using AG490 , the Jak2 inhibitor . Positive_regulation IL1B JAK2 12686512 1106067 Finally , we show that is *involved* in the production of [IL-1beta] and IL-6 . Positive_regulation IL1B JAK2 16934228 1639080 In the present study , we investigated whether the activation of signaling *mediates* [IL-1beta] expression in pancreatic acinar AR42J cells stimulated with cerulein in vitro as well as the rats with cerulein pancreatitis in vivo using AG490 , the Jak2 inhibitor . Positive_regulation IL1B JAK3 16934228 1639081 In the present study , we investigated whether the activation of signaling *mediates* [IL-1beta] expression in pancreatic acinar AR42J cells stimulated with cerulein in vitro as well as the rats with cerulein pancreatitis in vivo using AG490 , the Jak2 inhibitor . Positive_regulation IL1B JUN 10884313 709537 However , pretreatment with oATP downregulated *activation* of NF-kappaB and by [IL-1beta] or TNFalpha . Positive_regulation IL1B JUN 10936515 720686 Dexamethasone *inhibits* [IL-1 beta] gene expression in LPS stimulated RAW 264.7 cells by blocking NF-kappa B/Rel and activation . Positive_regulation IL1B JUN 11052809 743450 Transcriptional regulation of the human [interleukin 1beta] gene by fibronectin : *role* of protein kinase C and . Positive_regulation IL1B JUN 11274229 797582 These data suggested that ( 1 ) constitutive and [IL-1beta-inducible] expression of MCP-1 was differently *regulated* by and NF-kappaB and ( 2 ) t-RA inhibited selectively the constitutive expression of MCP-1 via intervention in the AP-1 pathway . Positive_regulation IL1B JUN 11739520 886552 [IL-1beta] regulation of glucose transport in chondrocytes depends on protein kinase C and p38 signal transduction pathways , and does not *require* phosphoinositide 3-kinase , extracellular signal related kinase , or N-terminal kinase activation . Positive_regulation IL1B JUN 11930628 894637 Enhancement of activity of NF kappa B and may positively *regulate* the production of IL-8 and [IL-1 beta] in the airflow obstruction . Positive_regulation IL1B JUN 12825130 1104486 A protein-1 (AP-1) inhibitor , curcumin , *reduced* the IL-17- , [IL-1beta-] , and TNF-alpha induced MMP-3 mRNA expression , and mitogen activated protein (MAP) kinase inhibitors ( U0126 , PD098059 , and SB203580 ) also blocked MMP-3 secretion . Positive_regulation IL1B JUN 15145599 1247716 Lipopolysaccharide (LPS) has a negative impact on long-term potentiation ( LTP ) in the rat hippocampus , which has been correlated with increased concentration of [interleukin-1 beta (IL-1 beta)] and *activation* of p38 and . Positive_regulation IL1B JUN 15683721 1370660 Although [IL-1beta] and IFN-gamma alone *induced* the activation of , the combination of these two cytokines ( IL-IF ) markedly inhibited the activation of AP-1 . Positive_regulation IL1B JUN 16106402 1498850 Ursodeoxycholic acid inhibits [interleukin 1 beta] [ corrected ] and deoxycholic acid induced *activation* of NF-kappaB and in human colon cancer cells . Positive_regulation IL1B JUN 16269458 1509289 On the other hand , TNFalpha and [IL-1beta] *induced* p38 , , and nuclear factor (NF)kappaB activation , pathways more closely related to stress response . Positive_regulation IL1B JUN 16399630 1513044 These results suggest that CHL *inhibits* [IL-1beta] production in macrophages stimulated with LPS at transcriptional level by blocking the phosphorylation of p38 and by suppressing the activation of transcription factors , NF-kappaB , NF-IL6 , and . Positive_regulation IL1B JUN 16729332 1565825 In conclusion , [IL-1 beta] and CDCA inhibit HNF4 alpha but *induce* , which in turn blocks HNF 4 alpha recruitment of PGC-1 alpha to the CYP7A1 chromatin and results in inhibition of CYP7A1 gene transcription . Positive_regulation IL1B JUN 17481780 1750509 In the present study , we found that [IL-1beta] stimulation *induced* activity within 15min in A549 cells . Positive_regulation IL1B JUN 18599158 2208596 and ( 3 ) S100B/RAGE induced upregulation of COX-2 , [IL-1beta] and TNF-alpha expression *requires* the concurrent activation of NF-kappaB and . Positive_regulation IL1B JUN 8386622 217820 We have now examined the *role* of in the regulation of the [IL-1 beta] gene expression by PKC and cAMP in THP-1 cells . Positive_regulation IL1B KITLG 7691319 228850 [Interleukin 1 beta (IL-1 beta)] *induced* a significant increase of soluble from both normal and DBA BMEF . Positive_regulation IL1B KRAS 14563479 1154848 Depletion of membrane bound cholesterol using methyl-beta-cyclodextrin , which also disrupts caveolar organization within the plasma membrane , abolished IL-1 beta induced NO release suggesting that [IL-1 beta] mediated *dependent* signaling in these cells involves the intermediacy of caveolae and their key constituents ( e.g. caveolin-1 ) in isolated beta cells . Positive_regulation IL1B KRAS 16543474 1574617 Interestingly , whereas IL-6 production required activation of both PI3K and Ras/Erk pathways , [IL-1beta] production was *dependent* only on activation , suggesting that SHIP may also regulate the Ras/Erk pathway in macrophages . Positive_regulation IL1B LAMA1 18434122 1926369 [IL-1beta] or TNF-alpha alone *induced* increased secretion of type IV collagen , , and nidogen-1/entactin , all of which contributed to this upregulation . Positive_regulation IL1B LAMB1 18434122 1926370 [IL-1beta] or TNF-alpha alone *induced* increased secretion of type IV collagen , , and nidogen-1/entactin , all of which contributed to this upregulation . Positive_regulation IL1B LAMC1 18434122 1926371 [IL-1beta] or TNF-alpha alone *induced* increased secretion of type IV collagen , , and nidogen-1/entactin , all of which contributed to this upregulation . Positive_regulation IL1B LANCL1 15730393 1377492 However , [IL-1beta] , but not IFN-gamma , *induced* IL-12 production by DCs without enhancing phenotypic maturation . Positive_regulation IL1B LBP 19010986 2029052 IL-6 , [IL-1beta] and cigarette smoke condensate *induced* the expression of and CD14 by airway epithelial cells . Positive_regulation IL1B LCN2 14662866 1177635 [IL-1beta] *induces* a > 10-fold up-regulation of expression in the type II pneumocyte derived cell line A549 cells , whereas TNF-alpha , IL-6 , and LPS had no effect . Positive_regulation IL1B LCN2 19009554 2016519 is *induced* by [interleukin-1beta] in murine adipocytes in vitro . Positive_regulation IL1B LEO1 10447739 577423 We conclude that CRH and can *induce* the expression of [IL-1beta] , but this is not obligatory for increased PGE2 release , and the effect of these stimuli on COX-2 expression is a direct , IL-1beta independent effect . Positive_regulation IL1B LEO1 16025141 1453424 TNF-alpha was necessary for the local *induced* [IL-1beta] production . Positive_regulation IL1B LEO1 16439466 1554562 H ( 2 ) O ( 2 ) causes formation of [IL-1beta] that may *induce* production of in the muscle , possibly closing a self sustaining cycle of production of inflammatory mediators . Positive_regulation IL1B LEO1 16829183 1591463 Both TNF-alpha and [IL-1beta] induced HUVEC platelet activating factor (PAF) production and was *required* for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine ) . Positive_regulation IL1B LEO1 1710753 158267 , alone and in combination with endotoxin , *caused* an increase in mRNA levels for [IL-1 beta] . Positive_regulation IL1B LEO1 8080039 270831 [Interleukin-1 beta] and tumor necrosis factor-alpha *induce* production by endothelium , and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist . Positive_regulation IL1B LEP 11792675 901930 Subdiaphragmatic vagotomy fails to inhibit intravenous *induced* [IL-1beta] expression in the hypothalamus . Positive_regulation IL1B LEP 11792675 901931 In the present study , we investigated whether intravenous *induced* [IL-1beta] expression in the hypothalamus is mediated via afferent vagus nerve . Positive_regulation IL1B LEP 11792675 901932 Subdiaphragmatic vagotomy did not significantly modify intravenous *induced* [IL-1beta] expression in the hypothalamus compared with that in sham treated mice . Positive_regulation IL1B LEP 11997182 939271 This could suggest that [IL-1beta] through a post-translational pathway *induced* an acute increase in , perhaps through the release of leptin from a pre formed pool within the adipose tissue . Positive_regulation IL1B LEP 12213309 985345 *regulates* [interleukin-1beta] expression in the brain via the STAT3 independent mechanisms . Positive_regulation IL1B LEP 12213309 985349 Although leptin did not induce STAT3 activation or suppressor of cytokine signaling3 ( SOCS3 ) expression in the hypothalamus of the db/db mice , which lack a functional Ob-Rb receptor , *increased* the [IL-1beta] levels to similar extents as normal mice . Positive_regulation IL1B LEP 12606591 1062923 *stimulated* IL-1 antagonist ( IL-1Ra ) , [IL-1beta] secretion and expression of IL-1 receptor type I (IL-1R tI) in both cell types . Positive_regulation IL1B LEP 12676369 1076767 Inhibition of *induced* [IL-1beta] expression by glucocorticoids in the brain . Positive_regulation IL1B LEP 12676369 1076769 In the present study , we examined whether these neuroendocrine effects of glucocorticoids are linked to changes in the *induced* expression of [IL-1beta] and STAT3 activation in the brain . Positive_regulation IL1B LEP 12676369 1076770 Pretreatment with dexamethasone dose dependently inhibited *induced* [IL-1beta] expression in the hypothalamus . Positive_regulation IL1B LEP 12676369 1076771 Moreover , dexamethasone inhibited *induced* [IL-1beta] expression in the primary cultured glial cells . Positive_regulation IL1B LEP 12676369 1076773 Therefore , it is suggested that glucocorticoid negatively regulates *induced* [IL-1beta] expression in the brain . Positive_regulation IL1B LEP 15905315 1426883 however , at 100 ng/ml and adiponectin at 0.1 and/or 0.5 microg/ml significantly *increased* the release of [IL-1beta] , IL-6 , TNFalpha , and PGE2 from human placenta and adipose tissue . Positive_regulation IL1B LEP 17350295 1777643 Also , had a detrimental effect on chondrocyte proliferation and *induced* [IL-1beta] production and MMP-9 and MMP-13 protein expression . Positive_regulation IL1B LEP 17419800 1766225 *induces* [interleukin-1beta] release from rat microglial cells through a caspase 1 independent mechanism . Positive_regulation IL1B LEP 17419800 1766228 In addition *induced* [IL-1beta] release occurs via a signal transducer and activator of transcription 3 ( STAT3 ) -dependent mechanism . Positive_regulation IL1B LEP 17419800 1766229 Western blot analysis demonstrated that *induced* the synthesis of [pro-IL-1beta] in microglial cells and the release of mature 17 kDa isoform into the culture medium . Positive_regulation IL1B LEP 17419800 1766231 *induced* [IL-1beta] release was neither inhibited by the pan-caspase inhibitor BOC-D-FMK , nor by the caspase 1 inhibitor Ac-YVAD-CHO indicating that IL-1 cleavage is independent of caspase activity . Positive_regulation IL1B LEP 17419800 1766232 These results confirm our earlier observations in vivo and demonstrate that microglia are an important source of [IL-1beta] in the brain in *response* to . Positive_regulation IL1B LEP 18263705 1911474 Chronic high glucose concentrations and *induce* [interleukin-1beta (IL-1beta)] secretion from pancreatic islets , an event that is possibly causal in promoting beta-cell dysfunction and death . Positive_regulation IL1B LEP 18547319 1952257 In vitro , both leptin and resistin could induce CXCL8 and tumour necrosis factor-alpha production by blood monocytes , and could additionally *induce* [IL-1beta] and IL-1 receptor antagonist production . Positive_regulation IL1B LEP 18798554 2000672 However , [IL-1beta] was only *increased* by in benign primary-EEC . Positive_regulation IL1B LEP 20560877 2296025 GOSD induced [IL-1beta] was further *enhanced* by in Akt/ERK dependent manner . Positive_regulation IL1B LIF 15613280 1357432 This activation of STAT3 could be abrogated by treatment with anti-LIF neutralizing antibody or anti-gp130 blocking antibody , indicating that induction of expression is *sufficient* and essential for STAT3 activation by [IL-1beta] . Positive_regulation IL1B LIF 8473500 216302 Recombinant human *increases* levels of [IL-1 beta] , IL-6 , and IL-8 mRNA in human articular chondrocytes as demonstrated by Northern blotting . Positive_regulation IL1B LIF 8473500 216307 In synoviocytes and neuronal as well as epithelial cell lines , *increases* [IL-1 beta] and IL-6 gene expression . Positive_regulation IL1B LIF 8895217 392431 Using neutralizing antibodies against IL-1 , we demonstrated that the effects of LIF were secondary to the *stimulation* by of [IL-1 beta] production by the chondrocytes . Positive_regulation IL1B LPA 16087165 1443235 Very low-density *induces* [interleukin-1beta] expression in macrophages . Positive_regulation IL1B LPA 18038269 1894661 In addition , [IL-1 beta] *induction* by was also observed in human primary macrophages . Positive_regulation IL1B LTA 12055225 951735 In this report , we demonstrate that LPS tolerized human promonocytic THP-1 cells develop cross-tolerance and no longer respond to *induced* [IL-1beta/TNF-alpha] production , indicating that disruption of common intracellular signaling is responsible for the decreased IL-1beta/TNF-alpha production . Positive_regulation IL1B LTA 12691617 1080371 LPS-TLR4 adapted human THP-1 promonocytic cells cross-adapt to *induced* [IL-1beta/TNF-alpha] production , suggesting disruption of a common intracellular signaling event ( s ) . Positive_regulation IL1B LTA 18501625 1928142 We found that ApoA-I could attenuate LTA induced acute lung injury and inflammation and significantly inhibit *induced* [IL-1beta] and TNF-alpha accumulation in the serum ( P < 0.01 and P < 0.05 , respectively ) , as well as in bronchoalveolar lavage (BAL) fluid ( P < 0.01 and P < 0.05 , respectively ) . Positive_regulation IL1B LTA 19124206 2060811 Infection of pigs with PRRSV also resulted in an increased secretion of [IL-1beta] by AMs in *response* to stimulation , and IL-6 by PBMCs in response to lipopolysaccharide (LPS) and LTA stimulation . Positive_regulation IL1B LTA 19250704 2182420 These data indicate that dependent TLR2 activation in odontoblasts and pulp fibroblasts , in contrast to immature DCs , does not *lead* to significant TNF-alpha and [IL-1beta] production , but that all three cell types influence the pulp inflammatory/immune response through CXCL8 synthesis and secretion . Positive_regulation IL1B LTA 19448156 2202596 In vivo LPS exposed alveolar macrophages were primed , as reflected by increased ex vivo LPS- and *induced* [IL-1 beta] and IL-6 gene expression and production compared with in vivo saline exposed alveolar macrophages . Positive_regulation IL1B LTA 19720398 2145314 Interestingly , LT showed a minimal change in *induced* [IL-1beta] expression while LT highly enhanced the LPS induced IL-1beta expression . Positive_regulation IL1B LTB 11908571 923610 *stimulated* [IL-1beta] and TNF-alpha synthesis with an EC50 of 190 +/- 35 and 45 +/- 9 nmol/l , respectively . Positive_regulation IL1B LTB 15320881 1286565 16-phe-LXA4 , LPS and , but not LXA4 , *induced* gene expression of [IL-1beta] in MO . IL-1beta protein synthesis increased by LPS ( 1500-fold ) , LTB4 ( 280-fold ) and 16-phe-LXA4 ( 30-fold ) . Positive_regulation IL1B LTB 15320881 1286566 Prior exposure of MO to 16-phe-LXA4 , but not LXA4 , reduced *induced* synthesis of [IL-1beta] with 66 % , IL-6 with 20 % and IL-1Ra with 29 % . Positive_regulation IL1B LTB 17068631 1637601 Bestatin ( 100 mg/L ) could also remarkably diminish *induced* mRNA expressions of TNF-alpha ( 86 % ) and [IL-1beta] ( 79 % ) . Positive_regulation IL1B LTB 17068631 1637603 of synovial membrance cells in rheumatoid arthritis could *induce* expressions of TNF-alpha and [IL-1beta] at mRNA level , and their expression at mRNA level had been quantified successfully . Positive_regulation IL1B LTB 18472956 289998 However , neither TNFalpha nor [IL-1beta] *induced* a significant ( 4 ) production in SMC alone or AM alone after 24 h of incubation . Positive_regulation IL1B LTB 19809821 2271949 Exogenous remarkably *increased* the expression of TNFalpha and [IL1beta] at both the mRNA level and the protein level . Positive_regulation IL1B LTB 8016588 262663 We examined the *role* of in the production of [Interleukin-1 beta (IL-1 beta)] by rheumatoid synovial cells since a substantial amount of LTB4 has been detected in the synovial fluid from patients with rheumatoid arthritis . Positive_regulation IL1B LTB 8016588 262665 The production of [IL-1 beta] was *augmented* by at concentrations of 10 ( -9 ) to 10 ( -8 ) M . Positive_regulation IL1B LTB 9777883 540269 In conclusion , beta2-agonists exhibited only minor effects on IL-1beta secretion from blood monocytes and no effect on from either cell type , and budesonide effectively *inhibited* the [IL-1beta] release in blood monocytes , but not in alveolar macrophages . Positive_regulation IL1B LTF 11779159 900033 Human *activates* transcription of [IL-1beta] gene in mammalian cells . Positive_regulation IL1B LYN 18453587 1909118 Using pharmacological inhibitors and small interfering RNA gene knockdown , we demonstrated that concomitant activation of , Pyk2 , and class IA PI3K are *required* for gp120 induced [IL-1beta] production . Positive_regulation IL1B MALT1 12174794 974530 The blockade of IFN-gamma and TNF-alpha did not inhibit the protective effect of MLT but when IL-1 beta was neutralized , 100 % of the infected mice died suggesting that [IL-1 beta] *induced* by treatment is a target cytokine to generate an immune response against the viral infection . Positive_regulation IL1B MAP2K1 11179516 784780 EGF receptor kinase inhibitor PD153035 and AG1478 and inhibitor PD98059 also *blocked* [IL-1 beta] induction of MMP-1 in cultured human keratinocytes . Positive_regulation IL1B MAP2K1 11527379 853352 These data suggest that the neuroprotective effect of inhibition may be *mediated* by suppression of [IL-1beta] . Positive_regulation IL1B MAP2K1 15613280 1357425 These changes are blocked by the MEK1/2 specific inhibitor U0126 , indicating that is *essential* for [IL-1beta] signaling in TT cells . Positive_regulation IL1B MAP2K1 15665520 1365600 The study shows that PI3K but not inhibition resulted in the *loss* of hypoxic and [IL-1beta] induced HIF-1alpha accumulation , whereas VEGF synthesis was reduced by either intervention . Positive_regulation IL1B MAP2K1 17178391 1679715 Selective inhibitors of p38 ( mapk ) ( SB203580 ) or of , the direct upstream activator of ERK1/2 ( PD98059 ) , *reduced* the synthesis of [IL-1beta] , TNFalpha , IL-6 and IL-8 induced by either the chaperonins or LPS . Positive_regulation IL1B MAP2K1 17404266 1721905 The release of UA-induced [IL-1beta] was significantly *inhibited* by the inhibitors of p38 MAPK , , ATP binding cassette transporter , and caspase-1 . Positive_regulation IL1B MAP2K2 11179516 784781 EGF receptor kinase inhibitor PD153035 and AG1478 and inhibitor PD98059 also *blocked* [IL-1 beta] induction of MMP-1 in cultured human keratinocytes . Positive_regulation IL1B MAP2K3 11179516 784782 EGF receptor kinase inhibitor PD153035 and AG1478 and inhibitor PD98059 also *blocked* [IL-1 beta] induction of MMP-1 in cultured human keratinocytes . Positive_regulation IL1B MAP2K3 17032166 1630733 MAPK signaling is *required* for [IL-1beta] and TNF-alpha induced RANKL expression in bone marrow stromal cells . Positive_regulation IL1B MAP2K4 11179516 784783 EGF receptor kinase inhibitor PD153035 and AG1478 and inhibitor PD98059 also *blocked* [IL-1 beta] induction of MMP-1 in cultured human keratinocytes . Positive_regulation IL1B MAP2K5 11179516 784784 EGF receptor kinase inhibitor PD153035 and AG1478 and inhibitor PD98059 also *blocked* [IL-1 beta] induction of MMP-1 in cultured human keratinocytes . Positive_regulation IL1B MAP2K6 11179516 784785 EGF receptor kinase inhibitor PD153035 and AG1478 and inhibitor PD98059 also *blocked* [IL-1 beta] induction of MMP-1 in cultured human keratinocytes . Positive_regulation IL1B MAP2K7 11179516 784786 EGF receptor kinase inhibitor PD153035 and AG1478 and inhibitor PD98059 also *blocked* [IL-1 beta] induction of MMP-1 in cultured human keratinocytes . Positive_regulation IL1B MAP3K7 15917296 1433613 [IL-1beta] transiently *induces* association between and the MAD homology 2 domain of SMAD3 , resulting in SMAD3 phosphorylation . Positive_regulation IL1B MAP3K7 17348859 1733938 We also show that MDP activates ERK1 ( extracellular-signal regulated kinase 1 ) /ERK2 and p38alpha MAPK in human peripheral-blood mononuclear cells and that the activity of both MAPKs and are *required* for MDP induced signalling and production of [IL-1beta] and TNFalpha in these cells . Positive_regulation IL1B MAP3K8 19933865 2172049 ( Map3k8 ) is *critical* for host defense against Listeria monocytogenes and [IL-1 beta] production . Positive_regulation IL1B MAP3K8 19933865 2172091 In contrast to the cell-type- and receptor-specific regulation of TNF , we found that is *essential* for [IL-1beta] production from both macrophages and dendritic cells . Positive_regulation IL1B MAPK1 10089132 600019 In contrast , does not *mediate* [IL-1beta] induced MCP-1 gene expression . Positive_regulation IL1B MAPK1 10228013 610605 The *role* of p38 in [IL-1 beta] transcription . Positive_regulation IL1B MAPK1 10228013 610644 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Positive_regulation IL1B MAPK1 10228013 610698 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Positive_regulation IL1B MAPK1 10775561 686671 These observations , combined with previous results , indicate that p44/42 activation is *required* for [interleukin-1beta] induction of iNOS and that N-acetyl-L-cysteine may act as a reducing agent and facilitate interleukin-1beta induced iNOS expression through a reduction/oxidation related mechanism involving potentiation of cytokine activation of the p44/42 MAPK signaling pathway . Positive_regulation IL1B MAPK1 10845922 700736 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Positive_regulation IL1B MAPK1 11032891 740438 [IL-1beta] *induces* p38 phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation IL1B MAPK1 11153597 761148 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as tumour necrosis factor-alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] , in vitro and in vivo by inhibiting p38 . Positive_regulation IL1B MAPK1 11281731 764730 *Activation* of by IGF1 and [IL1beta] was studied using a phosphorylation-specific antibody . Positive_regulation IL1B MAPK1 11698472 878036 [IL-1beta] *induced* phosphorylation and activation of p38 and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation IL1B MAPK1 11728947 884766 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Positive_regulation IL1B MAPK1 11777983 899938 Furthermore , IL-17 , IL-1beta , and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs , and specific inhibitors ( SB203580 , PD98059 , and U0216 ) significantly *reduced* IL-17- , [IL-1beta-] , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Positive_regulation IL1B MAPK1 12117921 964649 [IL-1beta] mRNA expression by neutrophils was not *dependent* on p38 , and p38 MAPK was not activated in neutrophils incubated with A. phagocytophila . Positive_regulation IL1B MAPK1 12483539 1024816 Exogenous expression of either SHPS-1 mutants that lack SHP-2 binding function or a dominant negative mutant of SHP-2 markedly inhibited the *activation* of and Akt by [IL-1beta] , whereas wild type SHPS-1 did not . Positive_regulation IL1B MAPK1 12676746 1076835 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Positive_regulation IL1B MAPK1 12734378 1087359 Our results indicate that A beta induced expression of cytokines ( TNF-alpha and [IL-1 beta] ) and chemokines ( MCP-1 , IL-8 , and MIP-1 beta ) in THP-1 monocytes *involves* activation of and downstream activation of Egr-1 . Positive_regulation IL1B MAPK1 12825130 1104487 A c-Jun/activating protein-1 (AP-1) inhibitor , curcumin , reduced the IL-17- , [IL-1beta-] , and TNF-alpha induced MMP-3 mRNA expression , and inhibitors ( U0126 , PD098059 , and SB203580 ) also *blocked* MMP-3 secretion . Positive_regulation IL1B MAPK1 12826666 1134596 Studies with specific inhibitors of MAPKs showed that p38 activation was *necessary* for both [IL-1 beta] and MMP-1 induction , but Erk activation was required only for MMP-1 induction . Positive_regulation IL1B MAPK1 15039421 1251212 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of [pro-IL-1beta] , and RIP2 dependent *activation* of NF-kappaB and p38 mediated by the caspase recruitment domain . Positive_regulation IL1B MAPK1 15111866 1241223 We further demonstrated that p38 MAPK is activated by [IL-1beta] and PDGF with different kinetics and that p38 is *required* for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation IL1B MAPK1 15195698 1260152 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Positive_regulation IL1B MAPK1 15208668 1281327 [IL-1beta] *induced* the activation of extracellular signal regulated kinases-1/2 and P38 , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation IL1B MAPK1 15248214 1271218 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of TNFalpha and [IL-1beta] by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation IL1B MAPK1 15597323 1361725 Simultaneous addition of both inhibitors resulted in low levels of IL-1 beta , suggesting that CD33 exerts an inhibitory role mediated by PI3K , while p38 signaling is *required* for [IL-1 beta] production . Positive_regulation IL1B MAPK1 16153910 1455402 The kidney was analyzed for expression of tumor necrosis factor alpha , [interleukin 1beta] , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation IL1B MAPK1 16271232 1479214 Similarly , the increased gene expression of proinflammatory cytokines TNF-alpha and [IL-1beta] in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation IL1B MAPK1 16305880 1486373 The p38 MAPK pathway indeed mediates the following important events in myocardial apoptosis and functional depression : *activated* protein kinase 2 , caspase-1 , caspase-3 and caspase-11 activation , and tumor necrosis factor , [interleukin-1beta] , interleukin-6 production after myocardial ischemia . Positive_regulation IL1B MAPK1 17032166 1630734 MKK3/6-p38 signaling is *required* for [IL-1beta] and TNF-alpha induced RANKL expression in bone marrow stromal cells . Positive_regulation IL1B MAPK1 17404266 1721906 The release of UA-induced [IL-1beta] was significantly *inhibited* by the inhibitors of p38 , MEK1/2 , ATP binding cassette transporter , and caspase-1 . Positive_regulation IL1B MAPK1 17438131 1742753 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by TNF-alpha and [interleukin-1beta] , but not by ansiomycin or sorbitol . Positive_regulation IL1B MAPK1 17453826 1730089 Beta-endorphin regulation of MAPKs in cultured human articular chondrocytes : inhibitors *prevent* the increase of [IL-1 beta] protein levels during beta-endorphin stimulation . Positive_regulation IL1B MAPK1 17530716 1751478 Blocking of p38 , but not , *resulted* in inhibition of both LPS mediated [IL-1beta] gene expression and the negative effects of LPS on matrix biosynthesis . Positive_regulation IL1B MAPK1 17628610 1775165 [IL-1 beta] release and caspase-1 activity induced by DSS were significantly *inhibited* by a kinase 1/2 inhibitor , a p38 MAPK inhibitor , and NAC , however , not by JNK1/2 or a protein kinase C inhibitor . Positive_regulation IL1B MAPK1 17920124 1844017 Moreover , the rIL-1beta induced [IL-1beta] and COX-2 expression were *reduced* by p38 inhibitor ( SB203580 ) and JNK inhibitor ( SP600125 ) , respectively . Positive_regulation IL1B MAPK1 17983423 1850427 The effect of chondroitin sulfate on [IL-1beta] *activation* of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and was documented by immunoblot . Positive_regulation IL1B MAPK1 18296636 1878869 Whereas the induction of TNFalpha , [IL-1beta] , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation IL1B MAPK1 18300858 1873447 However , the high concentration of D-glucose did increase iNOS expression in response to low concentrations of [IL-1beta] ( 2.5 and 5 ng/ml ) , as well as the IL-1beta induced *activation* of both and NF-kappaB . Positive_regulation IL1B MAPK1 18348730 1925299 The *activation* or inhibition of p38 by [IL-1beta] and/or SB203580 was analyzed by western blotting . Positive_regulation IL1B MAPK1 19362079 2081443 [IL-1beta] *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation IL1B MAPK1 19570828 2111273 In this study , we show that inhibition of ERK *suppressed* IL-23 and [IL-1beta] production by dendritic cells stimulated with TLR or dectin-1 agonists but did not affect IL-12p70 production . Positive_regulation IL1B MAPK1 20353947 2266431 In model 1 , a differentiation model , CLA *activation* of and induction of interleukin-8 (IL-8) , IL-6 , [IL-1beta] , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation IL1B MAPK1 20398663 2293919 In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6 , [interleukin-1beta] , and tumor necrosis factor alpha ) and *activation* of and NF-kappaB in Pirb-/- macrophages following bacterial activation . Positive_regulation IL1B MAPK1 21659536 2455178 Distinct roles for Nod2 protein and autocrine [interleukin-1beta] in muramyl dipeptide *induced* activation and cytokine secretion in human macrophages . Positive_regulation IL1B MAPK1 9551930 499102 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , [IL-1beta] , and TNF-alpha , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation IL1B MAPK10 10228013 610606 The *role* of p38 in [IL-1 beta] transcription . Positive_regulation IL1B MAPK10 10228013 610645 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Positive_regulation IL1B MAPK10 10228013 610699 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Positive_regulation IL1B MAPK10 10775561 686672 These observations , combined with previous results , indicate that p44/42 activation is *required* for [interleukin-1beta] induction of iNOS and that N-acetyl-L-cysteine may act as a reducing agent and facilitate interleukin-1beta induced iNOS expression through a reduction/oxidation related mechanism involving potentiation of cytokine activation of the p44/42 MAPK signaling pathway . Positive_regulation IL1B MAPK10 10845922 700737 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Positive_regulation IL1B MAPK10 11032891 740439 [IL-1beta] *induces* p38 phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation IL1B MAPK10 11153597 761149 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as tumour necrosis factor-alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] , in vitro and in vivo by inhibiting p38 . Positive_regulation IL1B MAPK10 11698472 878037 [IL-1beta] *induced* phosphorylation and activation of p38 and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation IL1B MAPK10 11728947 884767 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Positive_regulation IL1B MAPK10 11777983 899939 Furthermore , IL-17 , IL-1beta , and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs , and specific inhibitors ( SB203580 , PD98059 , and U0216 ) significantly *reduced* IL-17- , [IL-1beta-] , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Positive_regulation IL1B MAPK10 12117921 964650 [IL-1beta] mRNA expression by neutrophils was not *dependent* on p38 , and p38 MAPK was not activated in neutrophils incubated with A. phagocytophila . Positive_regulation IL1B MAPK10 12676746 1076836 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Positive_regulation IL1B MAPK10 12825130 1104488 A c-Jun/activating protein-1 (AP-1) inhibitor , curcumin , reduced the IL-17- , [IL-1beta-] , and TNF-alpha induced MMP-3 mRNA expression , and inhibitors ( U0126 , PD098059 , and SB203580 ) also *blocked* MMP-3 secretion . Positive_regulation IL1B MAPK10 12826666 1134597 Studies with specific inhibitors of MAPKs showed that p38 activation was *necessary* for both [IL-1 beta] and MMP-1 induction , but Erk activation was required only for MMP-1 induction . Positive_regulation IL1B MAPK10 15039421 1251213 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of [pro-IL-1beta] , and RIP2 dependent *activation* of NF-kappaB and p38 mediated by the caspase recruitment domain . Positive_regulation IL1B MAPK10 15111866 1241224 We further demonstrated that p38 MAPK is activated by [IL-1beta] and PDGF with different kinetics and that p38 is *required* for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation IL1B MAPK10 15195698 1260153 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Positive_regulation IL1B MAPK10 15208668 1281328 [IL-1beta] *induced* the activation of extracellular signal regulated kinases-1/2 and P38 , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation IL1B MAPK10 15248214 1271219 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of TNFalpha and [IL-1beta] by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation IL1B MAPK10 15597323 1361726 Simultaneous addition of both inhibitors resulted in low levels of IL-1 beta , suggesting that CD33 exerts an inhibitory role mediated by PI3K , while p38 signaling is *required* for [IL-1 beta] production . Positive_regulation IL1B MAPK10 16153910 1455403 The kidney was analyzed for expression of tumor necrosis factor alpha , [interleukin 1beta] , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation IL1B MAPK10 16271232 1479215 Similarly , the increased gene expression of proinflammatory cytokines TNF-alpha and [IL-1beta] in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation IL1B MAPK10 16305880 1486374 The p38 MAPK pathway indeed mediates the following important events in myocardial apoptosis and functional depression : *activated* protein kinase 2 , caspase-1 , caspase-3 and caspase-11 activation , and tumor necrosis factor , [interleukin-1beta] , interleukin-6 production after myocardial ischemia . Positive_regulation IL1B MAPK10 17032166 1630735 MKK3/6-p38 signaling is *required* for [IL-1beta] and TNF-alpha induced RANKL expression in bone marrow stromal cells . Positive_regulation IL1B MAPK10 17404266 1721907 The release of UA-induced [IL-1beta] was significantly *inhibited* by the inhibitors of p38 , MEK1/2 , ATP binding cassette transporter , and caspase-1 . Positive_regulation IL1B MAPK10 17438131 1742754 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by TNF-alpha and [interleukin-1beta] , but not by ansiomycin or sorbitol . Positive_regulation IL1B MAPK10 17453826 1730090 Beta-endorphin regulation of MAPKs in cultured human articular chondrocytes : inhibitors *prevent* the increase of [IL-1 beta] protein levels during beta-endorphin stimulation . Positive_regulation IL1B MAPK10 17628610 1775166 [IL-1 beta] release and caspase-1 activity induced by DSS were significantly *inhibited* by a MAPK kinase 1/2 inhibitor , a p38 inhibitor , and NAC , however , not by JNK1/2 or a protein kinase C inhibitor . Positive_regulation IL1B MAPK10 17920124 1844018 Moreover , the rIL-1beta induced [IL-1beta] and COX-2 expression were *reduced* by p38 inhibitor ( SB203580 ) and JNK inhibitor ( SP600125 ) , respectively . Positive_regulation IL1B MAPK10 17983423 1850428 The effect of chondroitin sulfate on [IL-1beta] *activation* of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and was documented by immunoblot . Positive_regulation IL1B MAPK10 18296636 1878870 Whereas the induction of TNFalpha , [IL-1beta] , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation IL1B MAPK10 18348730 1925300 The *activation* or inhibition of p38 by [IL-1beta] and/or SB203580 was analyzed by western blotting . Positive_regulation IL1B MAPK10 19362079 2081444 [IL-1beta] *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation IL1B MAPK10 19570828 2111274 In this study , we show that inhibition of ERK *suppressed* IL-23 and [IL-1beta] production by dendritic cells stimulated with TLR or dectin-1 agonists but did not affect IL-12p70 production . Positive_regulation IL1B MAPK10 20353947 2266432 In model 1 , a differentiation model , CLA *activation* of and induction of interleukin-8 (IL-8) , IL-6 , [IL-1beta] , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation IL1B MAPK10 20398663 2293920 In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6 , [interleukin-1beta] , and tumor necrosis factor alpha ) and *activation* of and NF-kappaB in Pirb-/- macrophages following bacterial activation . Positive_regulation IL1B MAPK10 21659536 2455179 Distinct roles for Nod2 protein and autocrine [interleukin-1beta] in muramyl dipeptide *induced* activation and cytokine secretion in human macrophages . Positive_regulation IL1B MAPK10 9551930 499103 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , [IL-1beta] , and TNF-alpha , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation IL1B MAPK11 10228013 610607 The *role* of p38 in [IL-1 beta] transcription . Positive_regulation IL1B MAPK11 10228013 610646 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Positive_regulation IL1B MAPK11 10228013 610700 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Positive_regulation IL1B MAPK11 10775561 686673 These observations , combined with previous results , indicate that p44/42 activation is *required* for [interleukin-1beta] induction of iNOS and that N-acetyl-L-cysteine may act as a reducing agent and facilitate interleukin-1beta induced iNOS expression through a reduction/oxidation related mechanism involving potentiation of cytokine activation of the p44/42 MAPK signaling pathway . Positive_regulation IL1B MAPK11 10845922 700738 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Positive_regulation IL1B MAPK11 11032891 740440 [IL-1beta] *induces* p38 phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation IL1B MAPK11 11153597 761150 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as tumour necrosis factor-alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] , in vitro and in vivo by inhibiting p38 . Positive_regulation IL1B MAPK11 11698472 878038 [IL-1beta] *induced* phosphorylation and activation of p38 and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation IL1B MAPK11 11728947 884768 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Positive_regulation IL1B MAPK11 11777983 899940 Furthermore , IL-17 , IL-1beta , and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs , and specific inhibitors ( SB203580 , PD98059 , and U0216 ) significantly *reduced* IL-17- , [IL-1beta-] , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Positive_regulation IL1B MAPK11 12117921 964651 [IL-1beta] mRNA expression by neutrophils was not *dependent* on p38 , and p38 MAPK was not activated in neutrophils incubated with A. phagocytophila . Positive_regulation IL1B MAPK11 12676746 1076837 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Positive_regulation IL1B MAPK11 12825130 1104489 A c-Jun/activating protein-1 (AP-1) inhibitor , curcumin , reduced the IL-17- , [IL-1beta-] , and TNF-alpha induced MMP-3 mRNA expression , and inhibitors ( U0126 , PD098059 , and SB203580 ) also *blocked* MMP-3 secretion . Positive_regulation IL1B MAPK11 12826666 1134598 Studies with specific inhibitors of MAPKs showed that p38 activation was *necessary* for both [IL-1 beta] and MMP-1 induction , but Erk activation was required only for MMP-1 induction . Positive_regulation IL1B MAPK11 15039421 1251214 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of [pro-IL-1beta] , and RIP2 dependent *activation* of NF-kappaB and p38 mediated by the caspase recruitment domain . Positive_regulation IL1B MAPK11 15111866 1241225 We further demonstrated that p38 MAPK is activated by [IL-1beta] and PDGF with different kinetics and that p38 is *required* for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation IL1B MAPK11 15195698 1260154 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Positive_regulation IL1B MAPK11 15208668 1281329 [IL-1beta] *induced* the activation of extracellular signal regulated kinases-1/2 and P38 , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation IL1B MAPK11 15248214 1271220 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of TNFalpha and [IL-1beta] by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation IL1B MAPK11 15597323 1361727 Simultaneous addition of both inhibitors resulted in low levels of IL-1 beta , suggesting that CD33 exerts an inhibitory role mediated by PI3K , while p38 signaling is *required* for [IL-1 beta] production . Positive_regulation IL1B MAPK11 16153910 1455404 The kidney was analyzed for expression of tumor necrosis factor alpha , [interleukin 1beta] , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation IL1B MAPK11 16271232 1479216 Similarly , the increased gene expression of proinflammatory cytokines TNF-alpha and [IL-1beta] in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation IL1B MAPK11 16305880 1486375 The p38 MAPK pathway indeed mediates the following important events in myocardial apoptosis and functional depression : *activated* protein kinase 2 , caspase-1 , caspase-3 and caspase-11 activation , and tumor necrosis factor , [interleukin-1beta] , interleukin-6 production after myocardial ischemia . Positive_regulation IL1B MAPK11 17032166 1630736 MKK3/6-p38 signaling is *required* for [IL-1beta] and TNF-alpha induced RANKL expression in bone marrow stromal cells . Positive_regulation IL1B MAPK11 17404266 1721908 The release of UA-induced [IL-1beta] was significantly *inhibited* by the inhibitors of p38 , MEK1/2 , ATP binding cassette transporter , and caspase-1 . Positive_regulation IL1B MAPK11 17438131 1742755 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by TNF-alpha and [interleukin-1beta] , but not by ansiomycin or sorbitol . Positive_regulation IL1B MAPK11 17453826 1730091 Beta-endorphin regulation of MAPKs in cultured human articular chondrocytes : inhibitors *prevent* the increase of [IL-1 beta] protein levels during beta-endorphin stimulation . Positive_regulation IL1B MAPK11 17628610 1775167 [IL-1 beta] release and caspase-1 activity induced by DSS were significantly *inhibited* by a kinase 1/2 inhibitor , a p38 MAPK inhibitor , and NAC , however , not by JNK1/2 or a protein kinase C inhibitor . Positive_regulation IL1B MAPK11 17920124 1844019 Moreover , the rIL-1beta induced [IL-1beta] and COX-2 expression were *reduced* by p38 inhibitor ( SB203580 ) and JNK inhibitor ( SP600125 ) , respectively . Positive_regulation IL1B MAPK11 17983423 1850429 The effect of chondroitin sulfate on [IL-1beta] *activation* of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and was documented by immunoblot . Positive_regulation IL1B MAPK11 18296636 1878871 Whereas the induction of TNFalpha , [IL-1beta] , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation IL1B MAPK11 18348730 1925301 The *activation* or inhibition of p38 by [IL-1beta] and/or SB203580 was analyzed by western blotting . Positive_regulation IL1B MAPK11 19362079 2081445 [IL-1beta] *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation IL1B MAPK11 19570828 2111275 In this study , we show that inhibition of ERK *suppressed* IL-23 and [IL-1beta] production by dendritic cells stimulated with TLR or dectin-1 agonists but did not affect IL-12p70 production . Positive_regulation IL1B MAPK11 20353947 2266433 In model 1 , a differentiation model , CLA *activation* of and induction of interleukin-8 (IL-8) , IL-6 , [IL-1beta] , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation IL1B MAPK11 20398663 2293921 In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6 , [interleukin-1beta] , and tumor necrosis factor alpha ) and *activation* of and NF-kappaB in Pirb-/- macrophages following bacterial activation . Positive_regulation IL1B MAPK11 21659536 2455180 Distinct roles for Nod2 protein and autocrine [interleukin-1beta] in muramyl dipeptide *induced* activation and cytokine secretion in human macrophages . Positive_regulation IL1B MAPK11 9551930 499104 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , [IL-1beta] , and TNF-alpha , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation IL1B MAPK12 10228013 610608 The *role* of p38 in [IL-1 beta] transcription . Positive_regulation IL1B MAPK12 10228013 610647 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Positive_regulation IL1B MAPK12 10228013 610701 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Positive_regulation IL1B MAPK12 10775561 686674 These observations , combined with previous results , indicate that p44/42 activation is *required* for [interleukin-1beta] induction of iNOS and that N-acetyl-L-cysteine may act as a reducing agent and facilitate interleukin-1beta induced iNOS expression through a reduction/oxidation related mechanism involving potentiation of cytokine activation of the p44/42 MAPK signaling pathway . Positive_regulation IL1B MAPK12 10845922 700739 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Positive_regulation IL1B MAPK12 11032891 740441 [IL-1beta] *induces* p38 phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation IL1B MAPK12 11153597 761151 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as tumour necrosis factor-alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] , in vitro and in vivo by inhibiting p38 . Positive_regulation IL1B MAPK12 11698472 878039 [IL-1beta] *induced* phosphorylation and activation of p38 and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation IL1B MAPK12 11728947 884769 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Positive_regulation IL1B MAPK12 11777983 899941 Furthermore , IL-17 , IL-1beta , and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs , and specific inhibitors ( SB203580 , PD98059 , and U0216 ) significantly *reduced* IL-17- , [IL-1beta-] , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Positive_regulation IL1B MAPK12 12117921 964652 [IL-1beta] mRNA expression by neutrophils was not *dependent* on p38 , and p38 MAPK was not activated in neutrophils incubated with A. phagocytophila . Positive_regulation IL1B MAPK12 12676746 1076838 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Positive_regulation IL1B MAPK12 12825130 1104490 A c-Jun/activating protein-1 (AP-1) inhibitor , curcumin , reduced the IL-17- , [IL-1beta-] , and TNF-alpha induced MMP-3 mRNA expression , and inhibitors ( U0126 , PD098059 , and SB203580 ) also *blocked* MMP-3 secretion . Positive_regulation IL1B MAPK12 12826666 1134599 Studies with specific inhibitors of MAPKs showed that p38 activation was *necessary* for both [IL-1 beta] and MMP-1 induction , but Erk activation was required only for MMP-1 induction . Positive_regulation IL1B MAPK12 15039421 1251215 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of [pro-IL-1beta] , and RIP2 dependent *activation* of NF-kappaB and p38 mediated by the caspase recruitment domain . Positive_regulation IL1B MAPK12 15111866 1241226 We further demonstrated that p38 MAPK is activated by [IL-1beta] and PDGF with different kinetics and that p38 is *required* for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation IL1B MAPK12 15195698 1260155 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Positive_regulation IL1B MAPK12 15208668 1281330 [IL-1beta] *induced* the activation of extracellular signal regulated kinases-1/2 and P38 , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation IL1B MAPK12 15248214 1271221 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of TNFalpha and [IL-1beta] by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation IL1B MAPK12 15597323 1361728 Simultaneous addition of both inhibitors resulted in low levels of IL-1 beta , suggesting that CD33 exerts an inhibitory role mediated by PI3K , while p38 signaling is *required* for [IL-1 beta] production . Positive_regulation IL1B MAPK12 16153910 1455405 The kidney was analyzed for expression of tumor necrosis factor alpha , [interleukin 1beta] , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation IL1B MAPK12 16271232 1479217 Similarly , the increased gene expression of proinflammatory cytokines TNF-alpha and [IL-1beta] in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation IL1B MAPK12 16305880 1486376 The p38 MAPK pathway indeed mediates the following important events in myocardial apoptosis and functional depression : *activated* protein kinase 2 , caspase-1 , caspase-3 and caspase-11 activation , and tumor necrosis factor , [interleukin-1beta] , interleukin-6 production after myocardial ischemia . Positive_regulation IL1B MAPK12 17032166 1630737 MKK3/6-p38 signaling is *required* for [IL-1beta] and TNF-alpha induced RANKL expression in bone marrow stromal cells . Positive_regulation IL1B MAPK12 17404266 1721909 The release of UA-induced [IL-1beta] was significantly *inhibited* by the inhibitors of p38 , MEK1/2 , ATP binding cassette transporter , and caspase-1 . Positive_regulation IL1B MAPK12 17438131 1742756 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by TNF-alpha and [interleukin-1beta] , but not by ansiomycin or sorbitol . Positive_regulation IL1B MAPK12 17453826 1730092 Beta-endorphin regulation of MAPKs in cultured human articular chondrocytes : inhibitors *prevent* the increase of [IL-1 beta] protein levels during beta-endorphin stimulation . Positive_regulation IL1B MAPK12 17628610 1775168 [IL-1 beta] release and caspase-1 activity induced by DSS were significantly *inhibited* by a MAPK kinase 1/2 inhibitor , a p38 inhibitor , and NAC , however , not by JNK1/2 or a protein kinase C inhibitor . Positive_regulation IL1B MAPK12 17920124 1844020 Moreover , the rIL-1beta induced [IL-1beta] and COX-2 expression were *reduced* by p38 inhibitor ( SB203580 ) and JNK inhibitor ( SP600125 ) , respectively . Positive_regulation IL1B MAPK12 17983423 1850430 The effect of chondroitin sulfate on [IL-1beta] *activation* of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and was documented by immunoblot . Positive_regulation IL1B MAPK12 18296636 1878872 Whereas the induction of TNFalpha , [IL-1beta] , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation IL1B MAPK12 18348730 1925302 The *activation* or inhibition of p38 by [IL-1beta] and/or SB203580 was analyzed by western blotting . Positive_regulation IL1B MAPK12 19362079 2081446 [IL-1beta] *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation IL1B MAPK12 19570828 2111276 In this study , we show that inhibition of ERK *suppressed* IL-23 and [IL-1beta] production by dendritic cells stimulated with TLR or dectin-1 agonists but did not affect IL-12p70 production . Positive_regulation IL1B MAPK12 20353947 2266434 In model 1 , a differentiation model , CLA *activation* of and induction of interleukin-8 (IL-8) , IL-6 , [IL-1beta] , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation IL1B MAPK12 20398663 2293922 In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6 , [interleukin-1beta] , and tumor necrosis factor alpha ) and *activation* of and NF-kappaB in Pirb-/- macrophages following bacterial activation . Positive_regulation IL1B MAPK12 21659536 2455181 Distinct roles for Nod2 protein and autocrine [interleukin-1beta] in muramyl dipeptide *induced* activation and cytokine secretion in human macrophages . Positive_regulation IL1B MAPK12 9551930 499105 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , [IL-1beta] , and TNF-alpha , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation IL1B MAPK13 10228013 610609 The *role* of p38 in [IL-1 beta] transcription . Positive_regulation IL1B MAPK13 10228013 610648 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Positive_regulation IL1B MAPK13 10228013 610702 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Positive_regulation IL1B MAPK13 10775561 686675 These observations , combined with previous results , indicate that p44/42 activation is *required* for [interleukin-1beta] induction of iNOS and that N-acetyl-L-cysteine may act as a reducing agent and facilitate interleukin-1beta induced iNOS expression through a reduction/oxidation related mechanism involving potentiation of cytokine activation of the p44/42 MAPK signaling pathway . Positive_regulation IL1B MAPK13 10845922 700740 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Positive_regulation IL1B MAPK13 11032891 740442 [IL-1beta] *induces* p38 phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation IL1B MAPK13 11153597 761152 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as tumour necrosis factor-alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] , in vitro and in vivo by inhibiting p38 . Positive_regulation IL1B MAPK13 11698472 878040 [IL-1beta] *induced* phosphorylation and activation of p38 and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation IL1B MAPK13 11728947 884770 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Positive_regulation IL1B MAPK13 11777983 899942 Furthermore , IL-17 , IL-1beta , and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs , and specific inhibitors ( SB203580 , PD98059 , and U0216 ) significantly *reduced* IL-17- , [IL-1beta-] , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Positive_regulation IL1B MAPK13 12117921 964653 [IL-1beta] mRNA expression by neutrophils was not *dependent* on p38 , and p38 MAPK was not activated in neutrophils incubated with A. phagocytophila . Positive_regulation IL1B MAPK13 12676746 1076839 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Positive_regulation IL1B MAPK13 12825130 1104491 A c-Jun/activating protein-1 (AP-1) inhibitor , curcumin , reduced the IL-17- , [IL-1beta-] , and TNF-alpha induced MMP-3 mRNA expression , and inhibitors ( U0126 , PD098059 , and SB203580 ) also *blocked* MMP-3 secretion . Positive_regulation IL1B MAPK13 12826666 1134600 Studies with specific inhibitors of MAPKs showed that p38 activation was *necessary* for both [IL-1 beta] and MMP-1 induction , but Erk activation was required only for MMP-1 induction . Positive_regulation IL1B MAPK13 15039421 1251216 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of [pro-IL-1beta] , and RIP2 dependent *activation* of NF-kappaB and p38 mediated by the caspase recruitment domain . Positive_regulation IL1B MAPK13 15111866 1241227 We further demonstrated that p38 MAPK is activated by [IL-1beta] and PDGF with different kinetics and that p38 is *required* for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation IL1B MAPK13 15195698 1260156 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Positive_regulation IL1B MAPK13 15208668 1281331 [IL-1beta] *induced* the activation of extracellular signal regulated kinases-1/2 and P38 , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation IL1B MAPK13 15248214 1271222 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of TNFalpha and [IL-1beta] by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation IL1B MAPK13 15597323 1361729 Simultaneous addition of both inhibitors resulted in low levels of IL-1 beta , suggesting that CD33 exerts an inhibitory role mediated by PI3K , while p38 signaling is *required* for [IL-1 beta] production . Positive_regulation IL1B MAPK13 16153910 1455406 The kidney was analyzed for expression of tumor necrosis factor alpha , [interleukin 1beta] , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation IL1B MAPK13 16271232 1479218 Similarly , the increased gene expression of proinflammatory cytokines TNF-alpha and [IL-1beta] in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation IL1B MAPK13 16305880 1486377 The p38 MAPK pathway indeed mediates the following important events in myocardial apoptosis and functional depression : *activated* protein kinase 2 , caspase-1 , caspase-3 and caspase-11 activation , and tumor necrosis factor , [interleukin-1beta] , interleukin-6 production after myocardial ischemia . Positive_regulation IL1B MAPK13 17032166 1630738 MKK3/6-p38 signaling is *required* for [IL-1beta] and TNF-alpha induced RANKL expression in bone marrow stromal cells . Positive_regulation IL1B MAPK13 17404266 1721910 The release of UA-induced [IL-1beta] was significantly *inhibited* by the inhibitors of p38 , MEK1/2 , ATP binding cassette transporter , and caspase-1 . Positive_regulation IL1B MAPK13 17438131 1742757 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by TNF-alpha and [interleukin-1beta] , but not by ansiomycin or sorbitol . Positive_regulation IL1B MAPK13 17453826 1730093 Beta-endorphin regulation of MAPKs in cultured human articular chondrocytes : inhibitors *prevent* the increase of [IL-1 beta] protein levels during beta-endorphin stimulation . Positive_regulation IL1B MAPK13 17628610 1775169 [IL-1 beta] release and caspase-1 activity induced by DSS were significantly *inhibited* by a kinase 1/2 inhibitor , a p38 MAPK inhibitor , and NAC , however , not by JNK1/2 or a protein kinase C inhibitor . Positive_regulation IL1B MAPK13 17920124 1844021 Moreover , the rIL-1beta induced [IL-1beta] and COX-2 expression were *reduced* by p38 inhibitor ( SB203580 ) and JNK inhibitor ( SP600125 ) , respectively . Positive_regulation IL1B MAPK13 17983423 1850431 The effect of chondroitin sulfate on [IL-1beta] *activation* of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and was documented by immunoblot . Positive_regulation IL1B MAPK13 18296636 1878873 Whereas the induction of TNFalpha , [IL-1beta] , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation IL1B MAPK13 18348730 1925303 The *activation* or inhibition of p38 by [IL-1beta] and/or SB203580 was analyzed by western blotting . Positive_regulation IL1B MAPK13 19362079 2081447 [IL-1beta] *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation IL1B MAPK13 19570828 2111277 In this study , we show that inhibition of ERK *suppressed* IL-23 and [IL-1beta] production by dendritic cells stimulated with TLR or dectin-1 agonists but did not affect IL-12p70 production . Positive_regulation IL1B MAPK13 20353947 2266435 In model 1 , a differentiation model , CLA *activation* of and induction of interleukin-8 (IL-8) , IL-6 , [IL-1beta] , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation IL1B MAPK13 20398663 2293923 In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6 , [interleukin-1beta] , and tumor necrosis factor alpha ) and *activation* of and NF-kappaB in Pirb-/- macrophages following bacterial activation . Positive_regulation IL1B MAPK13 21659536 2455182 Distinct roles for Nod2 protein and autocrine [interleukin-1beta] in muramyl dipeptide *induced* activation and cytokine secretion in human macrophages . Positive_regulation IL1B MAPK13 9551930 499106 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , [IL-1beta] , and TNF-alpha , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation IL1B MAPK14 10228013 610610 The *role* of p38 in [IL-1 beta] transcription . Positive_regulation IL1B MAPK14 10228013 610649 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Positive_regulation IL1B MAPK14 10228013 610703 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Positive_regulation IL1B MAPK14 10775561 686676 These observations , combined with previous results , indicate that p44/42 activation is *required* for [interleukin-1beta] induction of iNOS and that N-acetyl-L-cysteine may act as a reducing agent and facilitate interleukin-1beta induced iNOS expression through a reduction/oxidation related mechanism involving potentiation of cytokine activation of the p44/42 MAPK signaling pathway . Positive_regulation IL1B MAPK14 10845922 700741 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Positive_regulation IL1B MAPK14 11032891 740443 [IL-1beta] *induces* p38 phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation IL1B MAPK14 11153597 761153 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as tumour necrosis factor-alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] , in vitro and in vivo by inhibiting p38 . Positive_regulation IL1B MAPK14 11698472 878041 [IL-1beta] *induced* phosphorylation and activation of p38 and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation IL1B MAPK14 11728947 884771 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Positive_regulation IL1B MAPK14 11777983 899943 Furthermore , IL-17 , IL-1beta , and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs , and specific inhibitors ( SB203580 , PD98059 , and U0216 ) significantly *reduced* IL-17- , [IL-1beta-] , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Positive_regulation IL1B MAPK14 12117921 964654 [IL-1beta] mRNA expression by neutrophils was not *dependent* on p38 , and p38 MAPK was not activated in neutrophils incubated with A. phagocytophila . Positive_regulation IL1B MAPK14 12676746 1076840 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Positive_regulation IL1B MAPK14 12825130 1104492 A c-Jun/activating protein-1 (AP-1) inhibitor , curcumin , reduced the IL-17- , [IL-1beta-] , and TNF-alpha induced MMP-3 mRNA expression , and inhibitors ( U0126 , PD098059 , and SB203580 ) also *blocked* MMP-3 secretion . Positive_regulation IL1B MAPK14 12826666 1134601 Studies with specific inhibitors of MAPKs showed that p38 activation was *necessary* for both [IL-1 beta] and MMP-1 induction , but Erk activation was required only for MMP-1 induction . Positive_regulation IL1B MAPK14 15039421 1251217 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of [pro-IL-1beta] , and RIP2 dependent *activation* of NF-kappaB and p38 mediated by the caspase recruitment domain . Positive_regulation IL1B MAPK14 15111866 1241228 We further demonstrated that p38 MAPK is activated by [IL-1beta] and PDGF with different kinetics and that p38 is *required* for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation IL1B MAPK14 15195698 1260157 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Positive_regulation IL1B MAPK14 15208668 1281332 [IL-1beta] *induced* the activation of extracellular signal regulated kinases-1/2 and P38 , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation IL1B MAPK14 15248214 1271223 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of TNFalpha and [IL-1beta] by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation IL1B MAPK14 15597323 1361730 Simultaneous addition of both inhibitors resulted in low levels of IL-1 beta , suggesting that CD33 exerts an inhibitory role mediated by PI3K , while p38 signaling is *required* for [IL-1 beta] production . Positive_regulation IL1B MAPK14 16153910 1455407 The kidney was analyzed for expression of tumor necrosis factor alpha , [interleukin 1beta] , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation IL1B MAPK14 16271232 1479219 Similarly , the increased gene expression of proinflammatory cytokines TNF-alpha and [IL-1beta] in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation IL1B MAPK14 16305880 1486378 The p38 MAPK pathway indeed mediates the following important events in myocardial apoptosis and functional depression : *activated* protein kinase 2 , caspase-1 , caspase-3 and caspase-11 activation , and tumor necrosis factor , [interleukin-1beta] , interleukin-6 production after myocardial ischemia . Positive_regulation IL1B MAPK14 17032166 1630739 MKK3/6-p38 signaling is *required* for [IL-1beta] and TNF-alpha induced RANKL expression in bone marrow stromal cells . Positive_regulation IL1B MAPK14 17404266 1721911 The release of UA-induced [IL-1beta] was significantly *inhibited* by the inhibitors of p38 , MEK1/2 , ATP binding cassette transporter , and caspase-1 . Positive_regulation IL1B MAPK14 17438131 1742758 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by TNF-alpha and [interleukin-1beta] , but not by ansiomycin or sorbitol . Positive_regulation IL1B MAPK14 17453826 1730094 Beta-endorphin regulation of MAPKs in cultured human articular chondrocytes : inhibitors *prevent* the increase of [IL-1 beta] protein levels during beta-endorphin stimulation . Positive_regulation IL1B MAPK14 17628610 1775170 [IL-1 beta] release and caspase-1 activity induced by DSS were significantly *inhibited* by a MAPK kinase 1/2 inhibitor , a p38 inhibitor , and NAC , however , not by JNK1/2 or a protein kinase C inhibitor . Positive_regulation IL1B MAPK14 17920124 1844022 Moreover , the rIL-1beta induced [IL-1beta] and COX-2 expression were *reduced* by p38 inhibitor ( SB203580 ) and JNK inhibitor ( SP600125 ) , respectively . Positive_regulation IL1B MAPK14 17983423 1850432 The effect of chondroitin sulfate on [IL-1beta] *activation* of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and was documented by immunoblot . Positive_regulation IL1B MAPK14 18296636 1878874 Whereas the induction of TNFalpha , [IL-1beta] , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation IL1B MAPK14 18348730 1925304 The *activation* or inhibition of p38 by [IL-1beta] and/or SB203580 was analyzed by western blotting . Positive_regulation IL1B MAPK14 19362079 2081448 [IL-1beta] *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation IL1B MAPK14 19570828 2111278 In this study , we show that inhibition of ERK *suppressed* IL-23 and [IL-1beta] production by dendritic cells stimulated with TLR or dectin-1 agonists but did not affect IL-12p70 production . Positive_regulation IL1B MAPK14 20353947 2266436 In model 1 , a differentiation model , CLA *activation* of and induction of interleukin-8 (IL-8) , IL-6 , [IL-1beta] , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation IL1B MAPK14 20398663 2293924 In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6 , [interleukin-1beta] , and tumor necrosis factor alpha ) and *activation* of and NF-kappaB in Pirb-/- macrophages following bacterial activation . Positive_regulation IL1B MAPK14 21659536 2455183 Distinct roles for Nod2 protein and autocrine [interleukin-1beta] in muramyl dipeptide *induced* activation and cytokine secretion in human macrophages . Positive_regulation IL1B MAPK14 9551930 499107 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , [IL-1beta] , and TNF-alpha , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation IL1B MAPK15 10228013 610604 The *role* of p38 in [IL-1 beta] transcription . Positive_regulation IL1B MAPK15 10228013 610643 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Positive_regulation IL1B MAPK15 10228013 610697 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Positive_regulation IL1B MAPK15 10775561 686670 These observations , combined with previous results , indicate that p44/42 activation is *required* for [interleukin-1beta] induction of iNOS and that N-acetyl-L-cysteine may act as a reducing agent and facilitate interleukin-1beta induced iNOS expression through a reduction/oxidation related mechanism involving potentiation of cytokine activation of the p44/42 MAPK signaling pathway . Positive_regulation IL1B MAPK15 10845922 700735 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Positive_regulation IL1B MAPK15 11032891 740436 [IL-1beta] *induces* p38 phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation IL1B MAPK15 11153597 761147 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as tumour necrosis factor-alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] , in vitro and in vivo by inhibiting p38 . Positive_regulation IL1B MAPK15 11698472 878035 [IL-1beta] *induced* phosphorylation and activation of p38 and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation IL1B MAPK15 11728947 884765 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Positive_regulation IL1B MAPK15 11777983 899937 Furthermore , IL-17 , IL-1beta , and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs , and specific inhibitors ( SB203580 , PD98059 , and U0216 ) significantly *reduced* IL-17- , [IL-1beta-] , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Positive_regulation IL1B MAPK15 12117921 964648 [IL-1beta] mRNA expression by neutrophils was not *dependent* on p38 , and p38 MAPK was not activated in neutrophils incubated with A. phagocytophila . Positive_regulation IL1B MAPK15 12676746 1076834 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Positive_regulation IL1B MAPK15 12825130 1104485 A c-Jun/activating protein-1 (AP-1) inhibitor , curcumin , reduced the IL-17- , [IL-1beta-] , and TNF-alpha induced MMP-3 mRNA expression , and inhibitors ( U0126 , PD098059 , and SB203580 ) also *blocked* MMP-3 secretion . Positive_regulation IL1B MAPK15 12826666 1134595 Studies with specific inhibitors of MAPKs showed that p38 activation was *necessary* for both [IL-1 beta] and MMP-1 induction , but Erk activation was required only for MMP-1 induction . Positive_regulation IL1B MAPK15 15039421 1251211 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of [pro-IL-1beta] , and RIP2 dependent *activation* of NF-kappaB and p38 mediated by the caspase recruitment domain . Positive_regulation IL1B MAPK15 15111866 1241222 We further demonstrated that p38 MAPK is activated by [IL-1beta] and PDGF with different kinetics and that p38 is *required* for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation IL1B MAPK15 15195698 1260151 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Positive_regulation IL1B MAPK15 15208668 1281326 [IL-1beta] *induced* the activation of extracellular signal regulated kinases-1/2 and P38 , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation IL1B MAPK15 15248214 1271217 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of TNFalpha and [IL-1beta] by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation IL1B MAPK15 15597323 1361724 Simultaneous addition of both inhibitors resulted in low levels of IL-1 beta , suggesting that CD33 exerts an inhibitory role mediated by PI3K , while p38 signaling is *required* for [IL-1 beta] production . Positive_regulation IL1B MAPK15 16153910 1455401 The kidney was analyzed for expression of tumor necrosis factor alpha , [interleukin 1beta] , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation IL1B MAPK15 16271232 1479213 Similarly , the increased gene expression of proinflammatory cytokines TNF-alpha and [IL-1beta] in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation IL1B MAPK15 16305880 1486372 The p38 MAPK pathway indeed mediates the following important events in myocardial apoptosis and functional depression : *activated* protein kinase 2 , caspase-1 , caspase-3 and caspase-11 activation , and tumor necrosis factor , [interleukin-1beta] , interleukin-6 production after myocardial ischemia . Positive_regulation IL1B MAPK15 17032166 1630731 MKK3/6-p38 signaling is *required* for [IL-1beta] and TNF-alpha induced RANKL expression in bone marrow stromal cells . Positive_regulation IL1B MAPK15 17404266 1721904 The release of UA-induced [IL-1beta] was significantly *inhibited* by the inhibitors of p38 , MEK1/2 , ATP binding cassette transporter , and caspase-1 . Positive_regulation IL1B MAPK15 17438131 1742752 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by TNF-alpha and [interleukin-1beta] , but not by ansiomycin or sorbitol . Positive_regulation IL1B MAPK15 17453826 1730088 Beta-endorphin regulation of MAPKs in cultured human articular chondrocytes : inhibitors *prevent* the increase of [IL-1 beta] protein levels during beta-endorphin stimulation . Positive_regulation IL1B MAPK15 17628610 1775163 [IL-1 beta] release and caspase-1 activity induced by DSS were significantly *inhibited* by a kinase 1/2 inhibitor , a p38 MAPK inhibitor , and NAC , however , not by JNK1/2 or a protein kinase C inhibitor . Positive_regulation IL1B MAPK15 17920124 1844016 Moreover , the rIL-1beta induced [IL-1beta] and COX-2 expression were *reduced* by p38 inhibitor ( SB203580 ) and JNK inhibitor ( SP600125 ) , respectively . Positive_regulation IL1B MAPK15 17983423 1850425 The effect of chondroitin sulfate on [IL-1beta] *activation* of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and was documented by immunoblot . Positive_regulation IL1B MAPK15 18296636 1878867 Whereas the induction of TNFalpha , [IL-1beta] , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation IL1B MAPK15 18348730 1925298 The *activation* or inhibition of p38 by [IL-1beta] and/or SB203580 was analyzed by western blotting . Positive_regulation IL1B MAPK15 19362079 2081442 [IL-1beta] *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation IL1B MAPK15 19570828 2111272 In this study , we show that inhibition of ERK *suppressed* IL-23 and [IL-1beta] production by dendritic cells stimulated with TLR or dectin-1 agonists but did not affect IL-12p70 production . Positive_regulation IL1B MAPK15 20353947 2266430 In model 1 , a differentiation model , CLA *activation* of and induction of interleukin-8 (IL-8) , IL-6 , [IL-1beta] , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation IL1B MAPK15 20398663 2293918 In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6 , [interleukin-1beta] , and tumor necrosis factor alpha ) and *activation* of and NF-kappaB in Pirb-/- macrophages following bacterial activation . Positive_regulation IL1B MAPK15 21659536 2455177 Distinct roles for Nod2 protein and autocrine [interleukin-1beta] in muramyl dipeptide *induced* activation and cytokine secretion in human macrophages . Positive_regulation IL1B MAPK15 9551930 499101 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , [IL-1beta] , and TNF-alpha , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation IL1B MAPK3 10228013 610611 The *role* of p38 in [IL-1 beta] transcription . Positive_regulation IL1B MAPK3 10228013 610650 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Positive_regulation IL1B MAPK3 10228013 610704 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Positive_regulation IL1B MAPK3 10775561 686677 These observations , combined with previous results , indicate that p44/42 activation is *required* for [interleukin-1beta] induction of iNOS and that N-acetyl-L-cysteine may act as a reducing agent and facilitate interleukin-1beta induced iNOS expression through a reduction/oxidation related mechanism involving potentiation of cytokine activation of the p44/42 MAPK signaling pathway . Positive_regulation IL1B MAPK3 10845922 700742 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Positive_regulation IL1B MAPK3 10903806 713236 We conclude that [IL-1 beta] *induces* activation of both p38 and , and that ERK1/2 contributes to the pro-apoptotic effects of the cytokine in primary beta-cells . Positive_regulation IL1B MAPK3 11032891 740444 [IL-1beta] *induces* p38 phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation IL1B MAPK3 11153597 761154 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as tumour necrosis factor-alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] , in vitro and in vivo by inhibiting p38 . Positive_regulation IL1B MAPK3 11281731 764731 *Activation* of by IGF1 and [IL1beta] was studied using a phosphorylation-specific antibody . Positive_regulation IL1B MAPK3 11698472 878042 [IL-1beta] *induced* phosphorylation and activation of p38 and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation IL1B MAPK3 11728947 884772 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Positive_regulation IL1B MAPK3 11777983 899944 Furthermore , IL-17 , IL-1beta , and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs , and specific inhibitors ( SB203580 , PD98059 , and U0216 ) significantly *reduced* IL-17- , [IL-1beta-] , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Positive_regulation IL1B MAPK3 12117921 964655 [IL-1beta] mRNA expression by neutrophils was not *dependent* on p38 , and p38 MAPK was not activated in neutrophils incubated with A. phagocytophila . Positive_regulation IL1B MAPK3 12421347 1013462 In comparison , [IL-1beta] *induced* the release of PGE2 , IL-6 and activated NF-kappaB , p38 , JNK and in mixed glial cultures , but failed to induce any of these responses in microglial cell cultures . Positive_regulation IL1B MAPK3 12483539 1024817 Exogenous expression of either SHPS-1 mutants that lack SHP-2 binding function or a dominant negative mutant of SHP-2 markedly inhibited the *activation* of and Akt by [IL-1beta] , whereas wild type SHPS-1 did not . Positive_regulation IL1B MAPK3 12676746 1076841 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Positive_regulation IL1B MAPK3 12734378 1087360 Our results indicate that A beta induced expression of cytokines ( TNF-alpha and [IL-1 beta] ) and chemokines ( MCP-1 , IL-8 , and MIP-1 beta ) in THP-1 monocytes *involves* activation of and downstream activation of Egr-1 . Positive_regulation IL1B MAPK3 12825130 1104493 A c-Jun/activating protein-1 (AP-1) inhibitor , curcumin , reduced the IL-17- , [IL-1beta-] , and TNF-alpha induced MMP-3 mRNA expression , and inhibitors ( U0126 , PD098059 , and SB203580 ) also *blocked* MMP-3 secretion . Positive_regulation IL1B MAPK3 12826666 1134602 Studies with specific inhibitors of MAPKs showed that p38 activation was *necessary* for both [IL-1 beta] and MMP-1 induction , but Erk activation was required only for MMP-1 induction . Positive_regulation IL1B MAPK3 14960485 1242923 These data indicate that , in normal human cytotrophoblast cells , [IL-1 beta] induces HIF- 1 alpha mediated VEGF secretion and that IL-1 beta stimulated activation may be *involved* in this process . Positive_regulation IL1B MAPK3 15039421 1251218 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of [pro-IL-1beta] , and RIP2 dependent *activation* of NF-kappaB and p38 mediated by the caspase recruitment domain . Positive_regulation IL1B MAPK3 15111866 1241229 We further demonstrated that p38 MAPK is activated by [IL-1beta] and PDGF with different kinetics and that p38 is *required* for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation IL1B MAPK3 15195698 1260158 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Positive_regulation IL1B MAPK3 15208668 1281333 [IL-1beta] *induced* the activation of extracellular signal regulated kinases-1/2 and P38 , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation IL1B MAPK3 15248214 1271224 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of TNFalpha and [IL-1beta] by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation IL1B MAPK3 15597323 1361731 Simultaneous addition of both inhibitors resulted in low levels of IL-1 beta , suggesting that CD33 exerts an inhibitory role mediated by PI3K , while p38 signaling is *required* for [IL-1 beta] production . Positive_regulation IL1B MAPK3 15749024 1379450 Recombinant mouse [IL-1beta] *induced* strong activation of , p38 , JNK and NFkappa B , and significant release of IL-6 and PGE2 , which was blocked by IL-1ra . Positive_regulation IL1B MAPK3 16153910 1455408 The kidney was analyzed for expression of tumor necrosis factor alpha , [interleukin 1beta] , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation IL1B MAPK3 16271232 1479220 Similarly , the increased gene expression of proinflammatory cytokines TNF-alpha and [IL-1beta] in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation IL1B MAPK3 16305880 1486379 The p38 MAPK pathway indeed mediates the following important events in myocardial apoptosis and functional depression : *activated* protein kinase 2 , caspase-1 , caspase-3 and caspase-11 activation , and tumor necrosis factor , [interleukin-1beta] , interleukin-6 production after myocardial ischemia . Positive_regulation IL1B MAPK3 17032166 1630740 MKK3/6-p38 signaling is *required* for [IL-1beta] and TNF-alpha induced RANKL expression in bone marrow stromal cells . Positive_regulation IL1B MAPK3 17348859 1733939 We also show that MDP activates ( extracellular-signal regulated kinase 1 ) /ERK2 and p38alpha MAPK in human peripheral-blood mononuclear cells and that the activity of both MAPKs and TAK1 are *required* for MDP induced signalling and production of [IL-1beta] and TNFalpha in these cells . Positive_regulation IL1B MAPK3 17404266 1721912 The release of UA-induced [IL-1beta] was significantly *inhibited* by the inhibitors of p38 , MEK1/2 , ATP binding cassette transporter , and caspase-1 . Positive_regulation IL1B MAPK3 17438131 1742759 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by TNF-alpha and [interleukin-1beta] , but not by ansiomycin or sorbitol . Positive_regulation IL1B MAPK3 17453826 1730095 Beta-endorphin regulation of MAPKs in cultured human articular chondrocytes : inhibitors *prevent* the increase of [IL-1 beta] protein levels during beta-endorphin stimulation . Positive_regulation IL1B MAPK3 17530716 1751479 Blocking of p38 , but not , resulted in *inhibition* of both LPS mediated [IL-1beta] gene expression and the negative effects of LPS on matrix biosynthesis . Positive_regulation IL1B MAPK3 17628610 1775171 [IL-1 beta] release and caspase-1 activity induced by DSS were significantly *inhibited* by a kinase 1/2 inhibitor , a p38 MAPK inhibitor , and NAC , however , not by JNK1/2 or a protein kinase C inhibitor . Positive_regulation IL1B MAPK3 17920124 1844023 Moreover , the rIL-1beta induced [IL-1beta] and COX-2 expression were *reduced* by p38 inhibitor ( SB203580 ) and JNK inhibitor ( SP600125 ) , respectively . Positive_regulation IL1B MAPK3 17983423 1850433 The effect of chondroitin sulfate on [IL-1beta] *activation* of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and was documented by immunoblot . Positive_regulation IL1B MAPK3 18177344 1869953 inhibitor PD98059 *blocked* both TNF-alpha and [IL-1beta] , but not IL-6 production . Positive_regulation IL1B MAPK3 18296636 1878875 Whereas the induction of TNFalpha , [IL-1beta] , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation IL1B MAPK3 18300858 1873448 However , the high concentration of D-glucose did increase iNOS expression in response to low concentrations of [IL-1beta] ( 2.5 and 5 ng/ml ) , as well as the IL-1beta induced *activation* of both and NF-kappaB . Positive_regulation IL1B MAPK3 18348730 1925305 The *activation* or inhibition of p38 by [IL-1beta] and/or SB203580 was analyzed by western blotting . Positive_regulation IL1B MAPK3 19362079 2081449 [IL-1beta] *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation IL1B MAPK3 19570828 2111279 In this study , we show that inhibition of ERK *suppressed* IL-23 and [IL-1beta] production by dendritic cells stimulated with TLR or dectin-1 agonists but did not affect IL-12p70 production . Positive_regulation IL1B MAPK3 19782127 2195664 Cellular release of IL-1alpha , [IL-1beta] and IL-6 was significantly *attenuated* by curcumin and by inhibitors of the MAPKs ( PD98069 ) , p38 ( SB202190 ) and JNK ( SP600125 ) , whereas pyrrolidine dithiocarbamate ( PDTC ) attenuated the release of IL-6 , but not of IL-1alpha and IL-1beta . Positive_regulation IL1B MAPK3 20353947 2266437 In model 1 , a differentiation model , CLA *activation* of and induction of interleukin-8 (IL-8) , IL-6 , [IL-1beta] , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation IL1B MAPK3 20398663 2293925 In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6 , [interleukin-1beta] , and tumor necrosis factor alpha ) and *activation* of and NF-kappaB in Pirb-/- macrophages following bacterial activation . Positive_regulation IL1B MAPK3 21659536 2455184 Distinct roles for Nod2 protein and autocrine [interleukin-1beta] in muramyl dipeptide *induced* activation and cytokine secretion in human macrophages . Positive_regulation IL1B MAPK3 22053092 2557281 Biochemical inhibition of , but not JNK or MAPK14 , *reduced* LPS induced [IL1B] , IL6 , and IL8 expression in endometrial cells . Positive_regulation IL1B MAPK3 9551930 499108 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , [IL-1beta] , and TNF-alpha , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation IL1B MAPK3 9624172 511381 Differential *roles* of and p38 ( MAPK ) in [interleukin-1beta-] and tumor necrosis factor-alpha induced low density lipoprotein receptor expression in HepG2 cells . Positive_regulation IL1B MAPK4 10228013 610612 The *role* of p38 in [IL-1 beta] transcription . Positive_regulation IL1B MAPK4 10228013 610651 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Positive_regulation IL1B MAPK4 10228013 610705 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Positive_regulation IL1B MAPK4 10775561 686678 These observations , combined with previous results , indicate that p44/42 activation is *required* for [interleukin-1beta] induction of iNOS and that N-acetyl-L-cysteine may act as a reducing agent and facilitate interleukin-1beta induced iNOS expression through a reduction/oxidation related mechanism involving potentiation of cytokine activation of the p44/42 MAPK signaling pathway . Positive_regulation IL1B MAPK4 10845922 700743 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Positive_regulation IL1B MAPK4 11032891 740445 [IL-1beta] *induces* p38 phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation IL1B MAPK4 11153597 761155 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as tumour necrosis factor-alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] , in vitro and in vivo by inhibiting p38 . Positive_regulation IL1B MAPK4 11698472 878043 [IL-1beta] *induced* phosphorylation and activation of p38 and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation IL1B MAPK4 11728947 884773 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Positive_regulation IL1B MAPK4 11777983 899945 Furthermore , IL-17 , IL-1beta , and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs , and specific inhibitors ( SB203580 , PD98059 , and U0216 ) significantly *reduced* IL-17- , [IL-1beta-] , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Positive_regulation IL1B MAPK4 12117921 964656 [IL-1beta] mRNA expression by neutrophils was not *dependent* on p38 , and p38 MAPK was not activated in neutrophils incubated with A. phagocytophila . Positive_regulation IL1B MAPK4 12676746 1076842 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Positive_regulation IL1B MAPK4 12825130 1104494 A c-Jun/activating protein-1 (AP-1) inhibitor , curcumin , reduced the IL-17- , [IL-1beta-] , and TNF-alpha induced MMP-3 mRNA expression , and inhibitors ( U0126 , PD098059 , and SB203580 ) also *blocked* MMP-3 secretion . Positive_regulation IL1B MAPK4 12826666 1134603 Studies with specific inhibitors of MAPKs showed that p38 activation was *necessary* for both [IL-1 beta] and MMP-1 induction , but Erk activation was required only for MMP-1 induction . Positive_regulation IL1B MAPK4 15039421 1251219 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of [pro-IL-1beta] , and RIP2 dependent *activation* of NF-kappaB and p38 mediated by the caspase recruitment domain . Positive_regulation IL1B MAPK4 15111866 1241230 We further demonstrated that p38 MAPK is activated by [IL-1beta] and PDGF with different kinetics and that p38 is *required* for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation IL1B MAPK4 15195698 1260159 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Positive_regulation IL1B MAPK4 15208668 1281334 [IL-1beta] *induced* the activation of extracellular signal regulated kinases-1/2 and P38 , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation IL1B MAPK4 15248214 1271225 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of TNFalpha and [IL-1beta] by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation IL1B MAPK4 15597323 1361732 Simultaneous addition of both inhibitors resulted in low levels of IL-1 beta , suggesting that CD33 exerts an inhibitory role mediated by PI3K , while p38 signaling is *required* for [IL-1 beta] production . Positive_regulation IL1B MAPK4 16153910 1455409 The kidney was analyzed for expression of tumor necrosis factor alpha , [interleukin 1beta] , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation IL1B MAPK4 16271232 1479221 Similarly , the increased gene expression of proinflammatory cytokines TNF-alpha and [IL-1beta] in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation IL1B MAPK4 16305880 1486380 The p38 MAPK pathway indeed mediates the following important events in myocardial apoptosis and functional depression : *activated* protein kinase 2 , caspase-1 , caspase-3 and caspase-11 activation , and tumor necrosis factor , [interleukin-1beta] , interleukin-6 production after myocardial ischemia . Positive_regulation IL1B MAPK4 17032166 1630741 MKK3/6-p38 signaling is *required* for [IL-1beta] and TNF-alpha induced RANKL expression in bone marrow stromal cells . Positive_regulation IL1B MAPK4 17404266 1721913 The release of UA-induced [IL-1beta] was significantly *inhibited* by the inhibitors of p38 , MEK1/2 , ATP binding cassette transporter , and caspase-1 . Positive_regulation IL1B MAPK4 17438131 1742760 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by TNF-alpha and [interleukin-1beta] , but not by ansiomycin or sorbitol . Positive_regulation IL1B MAPK4 17453826 1730096 Beta-endorphin regulation of MAPKs in cultured human articular chondrocytes : inhibitors *prevent* the increase of [IL-1 beta] protein levels during beta-endorphin stimulation . Positive_regulation IL1B MAPK4 17628610 1775172 [IL-1 beta] release and caspase-1 activity induced by DSS were significantly *inhibited* by a MAPK kinase 1/2 inhibitor , a p38 inhibitor , and NAC , however , not by JNK1/2 or a protein kinase C inhibitor . Positive_regulation IL1B MAPK4 17920124 1844024 Moreover , the rIL-1beta induced [IL-1beta] and COX-2 expression were *reduced* by p38 inhibitor ( SB203580 ) and JNK inhibitor ( SP600125 ) , respectively . Positive_regulation IL1B MAPK4 17983423 1850434 The effect of chondroitin sulfate on [IL-1beta] *activation* of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and was documented by immunoblot . Positive_regulation IL1B MAPK4 18296636 1878876 Whereas the induction of TNFalpha , [IL-1beta] , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation IL1B MAPK4 18348730 1925306 The *activation* or inhibition of p38 by [IL-1beta] and/or SB203580 was analyzed by western blotting . Positive_regulation IL1B MAPK4 19362079 2081450 [IL-1beta] *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation IL1B MAPK4 19570828 2111280 In this study , we show that inhibition of ERK *suppressed* IL-23 and [IL-1beta] production by dendritic cells stimulated with TLR or dectin-1 agonists but did not affect IL-12p70 production . Positive_regulation IL1B MAPK4 20353947 2266438 In model 1 , a differentiation model , CLA *activation* of and induction of interleukin-8 (IL-8) , IL-6 , [IL-1beta] , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation IL1B MAPK4 20398663 2293926 In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6 , [interleukin-1beta] , and tumor necrosis factor alpha ) and *activation* of and NF-kappaB in Pirb-/- macrophages following bacterial activation . Positive_regulation IL1B MAPK4 21659536 2455185 Distinct roles for Nod2 protein and autocrine [interleukin-1beta] in muramyl dipeptide *induced* activation and cytokine secretion in human macrophages . Positive_regulation IL1B MAPK4 9551930 499109 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , [IL-1beta] , and TNF-alpha , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation IL1B MAPK6 10228013 610613 The *role* of p38 in [IL-1 beta] transcription . Positive_regulation IL1B MAPK6 10228013 610652 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Positive_regulation IL1B MAPK6 10228013 610706 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Positive_regulation IL1B MAPK6 10775561 686679 These observations , combined with previous results , indicate that p44/42 activation is *required* for [interleukin-1beta] induction of iNOS and that N-acetyl-L-cysteine may act as a reducing agent and facilitate interleukin-1beta induced iNOS expression through a reduction/oxidation related mechanism involving potentiation of cytokine activation of the p44/42 MAPK signaling pathway . Positive_regulation IL1B MAPK6 10845922 700744 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Positive_regulation IL1B MAPK6 11032891 740446 [IL-1beta] *induces* p38 phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation IL1B MAPK6 11153597 761156 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as tumour necrosis factor-alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] , in vitro and in vivo by inhibiting p38 . Positive_regulation IL1B MAPK6 11698472 878044 [IL-1beta] *induced* phosphorylation and activation of p38 and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation IL1B MAPK6 11728947 884774 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Positive_regulation IL1B MAPK6 11777983 899946 Furthermore , IL-17 , IL-1beta , and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs , and specific inhibitors ( SB203580 , PD98059 , and U0216 ) significantly *reduced* IL-17- , [IL-1beta-] , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Positive_regulation IL1B MAPK6 12117921 964657 [IL-1beta] mRNA expression by neutrophils was not *dependent* on p38 , and p38 MAPK was not activated in neutrophils incubated with A. phagocytophila . Positive_regulation IL1B MAPK6 12676746 1076843 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Positive_regulation IL1B MAPK6 12825130 1104495 A c-Jun/activating protein-1 (AP-1) inhibitor , curcumin , reduced the IL-17- , [IL-1beta-] , and TNF-alpha induced MMP-3 mRNA expression , and inhibitors ( U0126 , PD098059 , and SB203580 ) also *blocked* MMP-3 secretion . Positive_regulation IL1B MAPK6 12826666 1134604 Studies with specific inhibitors of MAPKs showed that p38 activation was *necessary* for both [IL-1 beta] and MMP-1 induction , but Erk activation was required only for MMP-1 induction . Positive_regulation IL1B MAPK6 15039421 1251220 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of [pro-IL-1beta] , and RIP2 dependent *activation* of NF-kappaB and p38 mediated by the caspase recruitment domain . Positive_regulation IL1B MAPK6 15111866 1241231 We further demonstrated that p38 MAPK is activated by [IL-1beta] and PDGF with different kinetics and that p38 is *required* for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation IL1B MAPK6 15195698 1260160 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Positive_regulation IL1B MAPK6 15208668 1281335 [IL-1beta] *induced* the activation of extracellular signal regulated kinases-1/2 and P38 , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation IL1B MAPK6 15248214 1271226 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of TNFalpha and [IL-1beta] by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation IL1B MAPK6 15597323 1361733 Simultaneous addition of both inhibitors resulted in low levels of IL-1 beta , suggesting that CD33 exerts an inhibitory role mediated by PI3K , while p38 signaling is *required* for [IL-1 beta] production . Positive_regulation IL1B MAPK6 16153910 1455410 The kidney was analyzed for expression of tumor necrosis factor alpha , [interleukin 1beta] , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation IL1B MAPK6 16271232 1479222 Similarly , the increased gene expression of proinflammatory cytokines TNF-alpha and [IL-1beta] in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation IL1B MAPK6 16305880 1486381 The p38 MAPK pathway indeed mediates the following important events in myocardial apoptosis and functional depression : *activated* protein kinase 2 , caspase-1 , caspase-3 and caspase-11 activation , and tumor necrosis factor , [interleukin-1beta] , interleukin-6 production after myocardial ischemia . Positive_regulation IL1B MAPK6 17032166 1630742 MKK3/6-p38 signaling is *required* for [IL-1beta] and TNF-alpha induced RANKL expression in bone marrow stromal cells . Positive_regulation IL1B MAPK6 17404266 1721914 The release of UA-induced [IL-1beta] was significantly *inhibited* by the inhibitors of p38 , MEK1/2 , ATP binding cassette transporter , and caspase-1 . Positive_regulation IL1B MAPK6 17438131 1742761 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by TNF-alpha and [interleukin-1beta] , but not by ansiomycin or sorbitol . Positive_regulation IL1B MAPK6 17453826 1730097 Beta-endorphin regulation of MAPKs in cultured human articular chondrocytes : inhibitors *prevent* the increase of [IL-1 beta] protein levels during beta-endorphin stimulation . Positive_regulation IL1B MAPK6 17628610 1775173 [IL-1 beta] release and caspase-1 activity induced by DSS were significantly *inhibited* by a kinase 1/2 inhibitor , a p38 MAPK inhibitor , and NAC , however , not by JNK1/2 or a protein kinase C inhibitor . Positive_regulation IL1B MAPK6 17920124 1844025 Moreover , the rIL-1beta induced [IL-1beta] and COX-2 expression were *reduced* by p38 inhibitor ( SB203580 ) and JNK inhibitor ( SP600125 ) , respectively . Positive_regulation IL1B MAPK6 17983423 1850435 The effect of chondroitin sulfate on [IL-1beta] *activation* of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and was documented by immunoblot . Positive_regulation IL1B MAPK6 18296636 1878877 Whereas the induction of TNFalpha , [IL-1beta] , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation IL1B MAPK6 18348730 1925307 The *activation* or inhibition of p38 by [IL-1beta] and/or SB203580 was analyzed by western blotting . Positive_regulation IL1B MAPK6 19362079 2081451 [IL-1beta] *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation IL1B MAPK6 19570828 2111281 In this study , we show that inhibition of ERK *suppressed* IL-23 and [IL-1beta] production by dendritic cells stimulated with TLR or dectin-1 agonists but did not affect IL-12p70 production . Positive_regulation IL1B MAPK6 20353947 2266439 In model 1 , a differentiation model , CLA *activation* of and induction of interleukin-8 (IL-8) , IL-6 , [IL-1beta] , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation IL1B MAPK6 20398663 2293927 In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6 , [interleukin-1beta] , and tumor necrosis factor alpha ) and *activation* of and NF-kappaB in Pirb-/- macrophages following bacterial activation . Positive_regulation IL1B MAPK6 21659536 2455186 Distinct roles for Nod2 protein and autocrine [interleukin-1beta] in muramyl dipeptide *induced* activation and cytokine secretion in human macrophages . Positive_regulation IL1B MAPK6 9551930 499110 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , [IL-1beta] , and TNF-alpha , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation IL1B MAPK7 10228013 610614 The *role* of p38 in [IL-1 beta] transcription . Positive_regulation IL1B MAPK7 10228013 610653 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Positive_regulation IL1B MAPK7 10228013 610707 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Positive_regulation IL1B MAPK7 10775561 686680 These observations , combined with previous results , indicate that p44/42 activation is *required* for [interleukin-1beta] induction of iNOS and that N-acetyl-L-cysteine may act as a reducing agent and facilitate interleukin-1beta induced iNOS expression through a reduction/oxidation related mechanism involving potentiation of cytokine activation of the p44/42 MAPK signaling pathway . Positive_regulation IL1B MAPK7 10845922 700745 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Positive_regulation IL1B MAPK7 11032891 740447 [IL-1beta] *induces* p38 phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation IL1B MAPK7 11153597 761157 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as tumour necrosis factor-alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] , in vitro and in vivo by inhibiting p38 . Positive_regulation IL1B MAPK7 11698472 878045 [IL-1beta] *induced* phosphorylation and activation of p38 and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation IL1B MAPK7 11728947 884775 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Positive_regulation IL1B MAPK7 11777983 899947 Furthermore , IL-17 , IL-1beta , and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs , and specific inhibitors ( SB203580 , PD98059 , and U0216 ) significantly *reduced* IL-17- , [IL-1beta-] , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Positive_regulation IL1B MAPK7 12117921 964658 [IL-1beta] mRNA expression by neutrophils was not *dependent* on p38 , and p38 MAPK was not activated in neutrophils incubated with A. phagocytophila . Positive_regulation IL1B MAPK7 12676746 1076844 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Positive_regulation IL1B MAPK7 12825130 1104496 A c-Jun/activating protein-1 (AP-1) inhibitor , curcumin , reduced the IL-17- , [IL-1beta-] , and TNF-alpha induced MMP-3 mRNA expression , and inhibitors ( U0126 , PD098059 , and SB203580 ) also *blocked* MMP-3 secretion . Positive_regulation IL1B MAPK7 12826666 1134605 Studies with specific inhibitors of MAPKs showed that p38 activation was *necessary* for both [IL-1 beta] and MMP-1 induction , but Erk activation was required only for MMP-1 induction . Positive_regulation IL1B MAPK7 15039421 1251221 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of [pro-IL-1beta] , and RIP2 dependent *activation* of NF-kappaB and p38 mediated by the caspase recruitment domain . Positive_regulation IL1B MAPK7 15111866 1241232 We further demonstrated that p38 MAPK is activated by [IL-1beta] and PDGF with different kinetics and that p38 is *required* for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation IL1B MAPK7 15195698 1260161 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Positive_regulation IL1B MAPK7 15208668 1281336 [IL-1beta] *induced* the activation of extracellular signal regulated kinases-1/2 and P38 , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation IL1B MAPK7 15248214 1271227 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of TNFalpha and [IL-1beta] by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation IL1B MAPK7 15597323 1361734 Simultaneous addition of both inhibitors resulted in low levels of IL-1 beta , suggesting that CD33 exerts an inhibitory role mediated by PI3K , while p38 signaling is *required* for [IL-1 beta] production . Positive_regulation IL1B MAPK7 16153910 1455411 The kidney was analyzed for expression of tumor necrosis factor alpha , [interleukin 1beta] , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation IL1B MAPK7 16271232 1479223 Similarly , the increased gene expression of proinflammatory cytokines TNF-alpha and [IL-1beta] in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation IL1B MAPK7 16305880 1486382 The p38 MAPK pathway indeed mediates the following important events in myocardial apoptosis and functional depression : *activated* protein kinase 2 , caspase-1 , caspase-3 and caspase-11 activation , and tumor necrosis factor , [interleukin-1beta] , interleukin-6 production after myocardial ischemia . Positive_regulation IL1B MAPK7 17032166 1630743 MKK3/6-p38 signaling is *required* for [IL-1beta] and TNF-alpha induced RANKL expression in bone marrow stromal cells . Positive_regulation IL1B MAPK7 17404266 1721915 The release of UA-induced [IL-1beta] was significantly *inhibited* by the inhibitors of p38 , MEK1/2 , ATP binding cassette transporter , and caspase-1 . Positive_regulation IL1B MAPK7 17438131 1742762 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by TNF-alpha and [interleukin-1beta] , but not by ansiomycin or sorbitol . Positive_regulation IL1B MAPK7 17453826 1730098 Beta-endorphin regulation of MAPKs in cultured human articular chondrocytes : inhibitors *prevent* the increase of [IL-1 beta] protein levels during beta-endorphin stimulation . Positive_regulation IL1B MAPK7 17628610 1775174 [IL-1 beta] release and caspase-1 activity induced by DSS were significantly *inhibited* by a MAPK kinase 1/2 inhibitor , a p38 inhibitor , and NAC , however , not by JNK1/2 or a protein kinase C inhibitor . Positive_regulation IL1B MAPK7 17920124 1844026 Moreover , the rIL-1beta induced [IL-1beta] and COX-2 expression were *reduced* by p38 inhibitor ( SB203580 ) and JNK inhibitor ( SP600125 ) , respectively . Positive_regulation IL1B MAPK7 17983423 1850436 The effect of chondroitin sulfate on [IL-1beta] *activation* of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and was documented by immunoblot . Positive_regulation IL1B MAPK7 18296636 1878878 Whereas the induction of TNFalpha , [IL-1beta] , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation IL1B MAPK7 18348730 1925308 The *activation* or inhibition of p38 by [IL-1beta] and/or SB203580 was analyzed by western blotting . Positive_regulation IL1B MAPK7 19362079 2081452 [IL-1beta] *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation IL1B MAPK7 19570828 2111282 In this study , we show that inhibition of ERK *suppressed* IL-23 and [IL-1beta] production by dendritic cells stimulated with TLR or dectin-1 agonists but did not affect IL-12p70 production . Positive_regulation IL1B MAPK7 20353947 2266440 In model 1 , a differentiation model , CLA *activation* of and induction of interleukin-8 (IL-8) , IL-6 , [IL-1beta] , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation IL1B MAPK7 20398663 2293928 In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6 , [interleukin-1beta] , and tumor necrosis factor alpha ) and *activation* of and NF-kappaB in Pirb-/- macrophages following bacterial activation . Positive_regulation IL1B MAPK7 21659536 2455187 Distinct roles for Nod2 protein and autocrine [interleukin-1beta] in muramyl dipeptide *induced* activation and cytokine secretion in human macrophages . Positive_regulation IL1B MAPK7 9551930 499111 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , [IL-1beta] , and TNF-alpha , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation IL1B MAPK8 10228013 610615 The *role* of p38 in [IL-1 beta] transcription . Positive_regulation IL1B MAPK8 10228013 610654 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Positive_regulation IL1B MAPK8 10228013 610708 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Positive_regulation IL1B MAPK8 10775561 686681 These observations , combined with previous results , indicate that p44/42 activation is *required* for [interleukin-1beta] induction of iNOS and that N-acetyl-L-cysteine may act as a reducing agent and facilitate interleukin-1beta induced iNOS expression through a reduction/oxidation related mechanism involving potentiation of cytokine activation of the p44/42 MAPK signaling pathway . Positive_regulation IL1B MAPK8 10845922 700746 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Positive_regulation IL1B MAPK8 11032891 740448 [IL-1beta] *induces* p38 phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation IL1B MAPK8 11153597 761158 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as tumour necrosis factor-alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] , in vitro and in vivo by inhibiting p38 . Positive_regulation IL1B MAPK8 11698472 878046 [IL-1beta] *induced* phosphorylation and activation of p38 and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation IL1B MAPK8 11728947 884776 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Positive_regulation IL1B MAPK8 11777983 899948 Furthermore , IL-17 , IL-1beta , and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs , and specific inhibitors ( SB203580 , PD98059 , and U0216 ) significantly *reduced* IL-17- , [IL-1beta-] , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Positive_regulation IL1B MAPK8 12117921 964659 [IL-1beta] mRNA expression by neutrophils was not *dependent* on p38 , and p38 MAPK was not activated in neutrophils incubated with A. phagocytophila . Positive_regulation IL1B MAPK8 12676746 1076845 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Positive_regulation IL1B MAPK8 12825130 1104497 A c-Jun/activating protein-1 (AP-1) inhibitor , curcumin , reduced the IL-17- , [IL-1beta-] , and TNF-alpha induced MMP-3 mRNA expression , and inhibitors ( U0126 , PD098059 , and SB203580 ) also *blocked* MMP-3 secretion . Positive_regulation IL1B MAPK8 12826666 1134606 Studies with specific inhibitors of MAPKs showed that p38 activation was *necessary* for both [IL-1 beta] and MMP-1 induction , but Erk activation was required only for MMP-1 induction . Positive_regulation IL1B MAPK8 15039421 1251222 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of [pro-IL-1beta] , and RIP2 dependent *activation* of NF-kappaB and p38 mediated by the caspase recruitment domain . Positive_regulation IL1B MAPK8 15111866 1241233 We further demonstrated that p38 MAPK is activated by [IL-1beta] and PDGF with different kinetics and that p38 is *required* for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation IL1B MAPK8 15195698 1260162 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Positive_regulation IL1B MAPK8 15208668 1281337 [IL-1beta] *induced* the activation of extracellular signal regulated kinases-1/2 and P38 , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation IL1B MAPK8 15248214 1271228 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of TNFalpha and [IL-1beta] by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation IL1B MAPK8 15597323 1361735 Simultaneous addition of both inhibitors resulted in low levels of IL-1 beta , suggesting that CD33 exerts an inhibitory role mediated by PI3K , while p38 signaling is *required* for [IL-1 beta] production . Positive_regulation IL1B MAPK8 16153910 1455412 The kidney was analyzed for expression of tumor necrosis factor alpha , [interleukin 1beta] , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation IL1B MAPK8 16271232 1479224 Similarly , the increased gene expression of proinflammatory cytokines TNF-alpha and [IL-1beta] in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation IL1B MAPK8 16305880 1486383 The p38 MAPK pathway indeed mediates the following important events in myocardial apoptosis and functional depression : *activated* protein kinase 2 , caspase-1 , caspase-3 and caspase-11 activation , and tumor necrosis factor , [interleukin-1beta] , interleukin-6 production after myocardial ischemia . Positive_regulation IL1B MAPK8 17032166 1630744 MKK3/6-p38 signaling is *required* for [IL-1beta] and TNF-alpha induced RANKL expression in bone marrow stromal cells . Positive_regulation IL1B MAPK8 17404266 1721916 The release of UA-induced [IL-1beta] was significantly *inhibited* by the inhibitors of p38 , MEK1/2 , ATP binding cassette transporter , and caspase-1 . Positive_regulation IL1B MAPK8 17438131 1742763 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by TNF-alpha and [interleukin-1beta] , but not by ansiomycin or sorbitol . Positive_regulation IL1B MAPK8 17453826 1730099 Beta-endorphin regulation of MAPKs in cultured human articular chondrocytes : inhibitors *prevent* the increase of [IL-1 beta] protein levels during beta-endorphin stimulation . Positive_regulation IL1B MAPK8 17628610 1775175 [IL-1 beta] release and caspase-1 activity induced by DSS were significantly *inhibited* by a kinase 1/2 inhibitor , a p38 MAPK inhibitor , and NAC , however , not by JNK1/2 or a protein kinase C inhibitor . Positive_regulation IL1B MAPK8 17920124 1844027 Moreover , the rIL-1beta induced [IL-1beta] and COX-2 expression were *reduced* by p38 inhibitor ( SB203580 ) and JNK inhibitor ( SP600125 ) , respectively . Positive_regulation IL1B MAPK8 17983423 1850437 The effect of chondroitin sulfate on [IL-1beta] *activation* of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and was documented by immunoblot . Positive_regulation IL1B MAPK8 18296636 1878879 Whereas the induction of TNFalpha , [IL-1beta] , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation IL1B MAPK8 18348730 1925309 The *activation* or inhibition of p38 by [IL-1beta] and/or SB203580 was analyzed by western blotting . Positive_regulation IL1B MAPK8 19362079 2081453 [IL-1beta] *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation IL1B MAPK8 19570828 2111283 In this study , we show that inhibition of ERK *suppressed* IL-23 and [IL-1beta] production by dendritic cells stimulated with TLR or dectin-1 agonists but did not affect IL-12p70 production . Positive_regulation IL1B MAPK8 20353947 2266441 In model 1 , a differentiation model , CLA *activation* of and induction of interleukin-8 (IL-8) , IL-6 , [IL-1beta] , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation IL1B MAPK8 20398663 2293929 In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6 , [interleukin-1beta] , and tumor necrosis factor alpha ) and *activation* of and NF-kappaB in Pirb-/- macrophages following bacterial activation . Positive_regulation IL1B MAPK8 21659536 2455188 Distinct roles for Nod2 protein and autocrine [interleukin-1beta] in muramyl dipeptide *induced* activation and cytokine secretion in human macrophages . Positive_regulation IL1B MAPK8 9551930 499112 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , [IL-1beta] , and TNF-alpha , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation IL1B MAPK9 10228013 610616 The *role* of p38 in [IL-1 beta] transcription . Positive_regulation IL1B MAPK9 10228013 610655 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Positive_regulation IL1B MAPK9 10228013 610709 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Positive_regulation IL1B MAPK9 10775561 686682 These observations , combined with previous results , indicate that p44/42 activation is *required* for [interleukin-1beta] induction of iNOS and that N-acetyl-L-cysteine may act as a reducing agent and facilitate interleukin-1beta induced iNOS expression through a reduction/oxidation related mechanism involving potentiation of cytokine activation of the p44/42 MAPK signaling pathway . Positive_regulation IL1B MAPK9 10845922 700747 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Positive_regulation IL1B MAPK9 11032891 740449 [IL-1beta] *induces* p38 phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation IL1B MAPK9 11153597 761159 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as tumour necrosis factor-alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] , in vitro and in vivo by inhibiting p38 . Positive_regulation IL1B MAPK9 11698472 878047 [IL-1beta] *induced* phosphorylation and activation of p38 and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation IL1B MAPK9 11728947 884777 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Positive_regulation IL1B MAPK9 11777983 899949 Furthermore , IL-17 , IL-1beta , and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs , and specific inhibitors ( SB203580 , PD98059 , and U0216 ) significantly *reduced* IL-17- , [IL-1beta-] , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Positive_regulation IL1B MAPK9 12117921 964660 [IL-1beta] mRNA expression by neutrophils was not *dependent* on p38 , and p38 MAPK was not activated in neutrophils incubated with A. phagocytophila . Positive_regulation IL1B MAPK9 12676746 1076846 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Positive_regulation IL1B MAPK9 12825130 1104498 A c-Jun/activating protein-1 (AP-1) inhibitor , curcumin , reduced the IL-17- , [IL-1beta-] , and TNF-alpha induced MMP-3 mRNA expression , and inhibitors ( U0126 , PD098059 , and SB203580 ) also *blocked* MMP-3 secretion . Positive_regulation IL1B MAPK9 12826666 1134607 Studies with specific inhibitors of MAPKs showed that p38 activation was *necessary* for both [IL-1 beta] and MMP-1 induction , but Erk activation was required only for MMP-1 induction . Positive_regulation IL1B MAPK9 15039421 1251223 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of [pro-IL-1beta] , and RIP2 dependent *activation* of NF-kappaB and p38 mediated by the caspase recruitment domain . Positive_regulation IL1B MAPK9 15111866 1241234 We further demonstrated that p38 MAPK is activated by [IL-1beta] and PDGF with different kinetics and that p38 is *required* for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation IL1B MAPK9 15195698 1260163 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Positive_regulation IL1B MAPK9 15208668 1281338 [IL-1beta] *induced* the activation of extracellular signal regulated kinases-1/2 and P38 , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation IL1B MAPK9 15248214 1271229 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of TNFalpha and [IL-1beta] by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation IL1B MAPK9 15597323 1361736 Simultaneous addition of both inhibitors resulted in low levels of IL-1 beta , suggesting that CD33 exerts an inhibitory role mediated by PI3K , while p38 signaling is *required* for [IL-1 beta] production . Positive_regulation IL1B MAPK9 16153910 1455413 The kidney was analyzed for expression of tumor necrosis factor alpha , [interleukin 1beta] , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation IL1B MAPK9 16271232 1479225 Similarly , the increased gene expression of proinflammatory cytokines TNF-alpha and [IL-1beta] in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation IL1B MAPK9 16305880 1486384 The p38 MAPK pathway indeed mediates the following important events in myocardial apoptosis and functional depression : *activated* protein kinase 2 , caspase-1 , caspase-3 and caspase-11 activation , and tumor necrosis factor , [interleukin-1beta] , interleukin-6 production after myocardial ischemia . Positive_regulation IL1B MAPK9 17032166 1630745 MKK3/6-p38 signaling is *required* for [IL-1beta] and TNF-alpha induced RANKL expression in bone marrow stromal cells . Positive_regulation IL1B MAPK9 17404266 1721917 The release of UA-induced [IL-1beta] was significantly *inhibited* by the inhibitors of p38 , MEK1/2 , ATP binding cassette transporter , and caspase-1 . Positive_regulation IL1B MAPK9 17438131 1742764 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by TNF-alpha and [interleukin-1beta] , but not by ansiomycin or sorbitol . Positive_regulation IL1B MAPK9 17453826 1730100 Beta-endorphin regulation of MAPKs in cultured human articular chondrocytes : inhibitors *prevent* the increase of [IL-1 beta] protein levels during beta-endorphin stimulation . Positive_regulation IL1B MAPK9 17628610 1775176 [IL-1 beta] release and caspase-1 activity induced by DSS were significantly *inhibited* by a MAPK kinase 1/2 inhibitor , a p38 inhibitor , and NAC , however , not by JNK1/2 or a protein kinase C inhibitor . Positive_regulation IL1B MAPK9 17920124 1844028 Moreover , the rIL-1beta induced [IL-1beta] and COX-2 expression were *reduced* by p38 inhibitor ( SB203580 ) and JNK inhibitor ( SP600125 ) , respectively . Positive_regulation IL1B MAPK9 17983423 1850438 The effect of chondroitin sulfate on [IL-1beta] *activation* of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and was documented by immunoblot . Positive_regulation IL1B MAPK9 18296636 1878880 Whereas the induction of TNFalpha , [IL-1beta] , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation IL1B MAPK9 18348730 1925310 The *activation* or inhibition of p38 by [IL-1beta] and/or SB203580 was analyzed by western blotting . Positive_regulation IL1B MAPK9 19362079 2081454 [IL-1beta] *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation IL1B MAPK9 19570828 2111284 In this study , we show that inhibition of ERK *suppressed* IL-23 and [IL-1beta] production by dendritic cells stimulated with TLR or dectin-1 agonists but did not affect IL-12p70 production . Positive_regulation IL1B MAPK9 20353947 2266442 In model 1 , a differentiation model , CLA *activation* of and induction of interleukin-8 (IL-8) , IL-6 , [IL-1beta] , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation IL1B MAPK9 20398663 2293930 In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6 , [interleukin-1beta] , and tumor necrosis factor alpha ) and *activation* of and NF-kappaB in Pirb-/- macrophages following bacterial activation . Positive_regulation IL1B MAPK9 21659536 2455189 Distinct roles for Nod2 protein and autocrine [interleukin-1beta] in muramyl dipeptide *induced* activation and cytokine secretion in human macrophages . Positive_regulation IL1B MAPK9 9551930 499113 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , [IL-1beta] , and TNF-alpha , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation IL1B MAST1 17607547 1765389 cell activation *induced* [IL-1beta] expression in particular in nearby CD68 positive synovial macrophages . Positive_regulation IL1B MAST2 17607547 1765390 cell activation *induced* [IL-1beta] expression in particular in nearby CD68 positive synovial macrophages . Positive_regulation IL1B MAST3 17607547 1765391 cell activation *induced* [IL-1beta] expression in particular in nearby CD68 positive synovial macrophages . Positive_regulation IL1B MAST4 17607547 1765392 cell activation *induced* [IL-1beta] expression in particular in nearby CD68 positive synovial macrophages . Positive_regulation IL1B MATN1 19840795 2165248 stimulation *leads* to the induction of MMP1 , MMP3 , MMP13 , COX-2 , iNOS , [IL-1beta] , TNFalpha , IL-6 and IL-8 . Positive_regulation IL1B MATN2 19840795 2165249 stimulation *leads* to the induction of MMP1 , MMP3 , MMP13 , COX-2 , iNOS , [IL-1beta] , TNFalpha , IL-6 and IL-8 . Positive_regulation IL1B MATN3 19840795 2165250 stimulation *leads* to the induction of MMP1 , MMP3 , MMP13 , COX-2 , iNOS , [IL-1beta] , TNFalpha , IL-6 and IL-8 . Positive_regulation IL1B MATN4 19840795 2165251 stimulation *leads* to the induction of MMP1 , MMP3 , MMP13 , COX-2 , iNOS , [IL-1beta] , TNFalpha , IL-6 and IL-8 . Positive_regulation IL1B MBL2 15381182 1298619 *enhances* [IL-1beta] and IL-10 induction by non-lipopolysaccharide (LPS) components of Neisseria meningitidis . Positive_regulation IL1B MBL2 15381182 1298620 Experiments with human mononuclear cells ( PBMCs ) showed that significantly *augmented* [IL-1beta] production after stimulation with LPS+ and LPS- meningococci , in a dose dependent fashion . Positive_regulation IL1B MBP 12911279 1122055 Patients in relapse had significantly increased spontaneous , PHA- and *induced* PBMC [IL-1beta] production compared with remission MS , and was increased compared ( PHA only ) with OND and healthy controls . Positive_regulation IL1B MBP 12911279 1122056 In contrast , MS patients in remission produced significantly less spontaneous and MBP induced TNF-alpha , spontaneous , PHA- and *induced* [IL-1beta] and PHA induced IFN-gamma together with increased production of biologically active TGF-beta1 . Positive_regulation IL1B MCM2 19131350 2079085 Fibronectin and [IL-1beta] levels were enhanced proportionately between the sexes in *response* to stimulation , whilst the increase in TNFalpha levels was greater in MCM stimulated female cells . Positive_regulation IL1B MCM3 19131350 2079086 Fibronectin and [IL-1beta] levels were enhanced proportionately between the sexes in *response* to stimulation , whilst the increase in TNFalpha levels was greater in MCM stimulated female cells . Positive_regulation IL1B MCM4 19131350 2079087 Fibronectin and [IL-1beta] levels were enhanced proportionately between the sexes in *response* to stimulation , whilst the increase in TNFalpha levels was greater in MCM stimulated female cells . Positive_regulation IL1B MCM5 19131350 2079088 Fibronectin and [IL-1beta] levels were enhanced proportionately between the sexes in *response* to stimulation , whilst the increase in TNFalpha levels was greater in MCM stimulated female cells . Positive_regulation IL1B MCM6 19131350 2079089 Fibronectin and [IL-1beta] levels were enhanced proportionately between the sexes in *response* to stimulation , whilst the increase in TNFalpha levels was greater in MCM stimulated female cells . Positive_regulation IL1B MCM7 19131350 2079090 Fibronectin and [IL-1beta] levels were enhanced proportionately between the sexes in *response* to stimulation , whilst the increase in TNFalpha levels was greater in MCM stimulated female cells . Positive_regulation IL1B MED1 16982859 1617263 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED10 16982859 1617258 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED11 16982859 1617261 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED13 16982859 1617245 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED13L 16982859 1617246 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED14 16982859 1617250 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED15 16982859 1617239 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED16 16982859 1617241 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED17 16982859 1617252 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED18 16982859 1617257 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED19 16982859 1617260 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED20 16982859 1617240 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED21 16982859 1617237 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED22 16982859 1617238 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED23 16982859 1617251 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED24 16982859 1617247 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED25 16982859 1617259 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED26 16982859 1617253 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED27 16982859 1617254 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED29 16982859 1617249 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED30 16982859 1617248 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED31 16982859 1617256 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED4 16982859 1617242 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED6 16982859 1617243 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED7 16982859 1617255 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MED8 16982859 1617244 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B MEFV 14634131 1170924 We also show that expression of the family proteins pyrin or cryopyrin/PYPAF1/NALP3 individually inhibits IL-1beta secretion but that coexpression of ASC with these proteins *results* in enhanced [IL-1beta] secretion . Positive_regulation IL1B MIF 15146413 1247758 *induced* IL-8 and [IL-1beta] transcriptional activation was studied in RA synovial fibroblasts by Northern blot analysis , enzyme linked immunosorbent assay , and electromobility shift assay . Positive_regulation IL1B MIF 15146413 1247762 The mRNA *up-regulation* of IL-8 and [IL-1beta] by was inhibited by 2 tyrosine kinase inhibitors , a protein kinase C ( PKC ) inhibitor , an activator protein 1 (AP-1) inhibitor , and by an NF-kappaB inhibitor . Positive_regulation IL1B MIF 19592246 2111939 Of note , compounds 7 , 22 , 23 , 24 , 25 and 27 inhibited the spontaneous secretion/release/recognition of MIF from freshly isolated human peripheral blood mononuclear cells and , more importantly , inhibited the *induced* production of interleukin-6 (IL-6) and/or [interleukin-1beta (IL-1beta)] significantly better than ISO-1 . Positive_regulation IL1B MIP 17015748 1629890 [IL-1beta] *induced* increased mRNA levels of , MCP-1 , RANTES , inducible NO synthase (iNOS) , and cyclooxygenase-2 (COX-2) in the IEC-18 cell line . Positive_regulation IL1B MIPEP 19002429 2022194 [IL-1beta] *induced* a time dependent increase in Mcp-1 and ( also known as Cxcl2 ) mRNA expression after 6 h of stimulation in insulinoma (INS)-1 and neonatal rat islet cells . Positive_regulation IL1B MIPEP 8553267 339970 A study was performed to determine whether [IL-1 beta] could *induce* the expression of in the lungs of Brown-Norway rats . Positive_regulation IL1B MMP1 10727770 678101 [IL-1beta] and TPA alone *induced* activity in HIG-82 cells . Positive_regulation IL1B MMP1 10895370 711584 In support of this result , [IL-1 beta] stimulation *induced* the expression of membrane type matrix-metalloproteinase ( ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation IL1B MMP1 11285378 799852 [rHu-IL-1beta] , but not rHu-IL-18 , *induced* ( MMP-1 ) in FLS . Positive_regulation IL1B MMP1 12568957 1057191 [IL-1 beta] *induces* COX2 , , -3 and -13 , ADAMTS-4 , IL-1 beta and IL-6 in human tendon cells . Positive_regulation IL1B MMP1 12826666 1134608 Studies with specific inhibitors of MAPKs showed that p38 MAPK activation was necessary for both [IL-1 beta] and *induction* , but Erk activation was required only for MMP-1 induction . Positive_regulation IL1B MMP1 14634122 1170895 [IL-1beta] and TNF-alpha *stimulated* FLSC extracellular signal regulated kinase ( ERK ) activation as well as and -13 release . Positive_regulation IL1B MMP1 14996278 1216210 [Interleukin-1beta] *induces* expression in cultured human gingival fibroblasts : role of cyclooxygenase-2 and prostaglandin E2 . Positive_regulation IL1B MMP1 15383690 1299070 Expression of and MMP-3 mRNAs was *induced* by [IL-1beta] . Positive_regulation IL1B MMP1 15979654 1459104 The expression of , -2 , and -3 *increased* markedly in the presence of [IL-1beta] after day 21 of culture . Positive_regulation IL1B MMP1 16399619 1513034 In human primary chondrocytes , the production of ( MMP-13 and -1 ) and prostaglandin E2 ( PGE2 ) was *induced* by [interleukin-1beta] . Positive_regulation IL1B MMP1 16460250 1522593 After labeling with these maghemite nanoparticles , HGF increased secretion of [IL-1beta] at D1 , probably *inducing* the increase of , -2 , and -3 and TIMP-2 . Positive_regulation IL1B MMP1 16549373 1582327 [IL-1beta] and TNFalpha strongly *induced* the expression of and -13 in SW1353 cells and HACs , whereas only TNFalpha was found to induce the expression of these two MMPs in JJ012 cells . Positive_regulation IL1B MMP1 17940116 1849316 We hypothesized that [IL-1beta] and TNF-alpha may *induce* and MMP-3 activity to promote PTD by degrading decidual and fetal membranes and cervical extracellular matrix . Positive_regulation IL1B MMP1 18060744 1846772 [IL-1beta] is involved in the up-regulation of UVA induced MMP-1 in dermal fibroblasts , and IL-1beta and MIF cytokine network *induce* and contribute to the loss of interstitial collagen in skin photoaging . Positive_regulation IL1B MMP1 22792188 2628360 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B MMP1 8041811 266764 From these data we suggest a UV-induced cytokine network consisting of IL-1 alpha , [IL-1 beta] and IL-6 , which via interrelated autocrine loops *induce* and thus may contribute to the loss of interstitial collagen in cutaneous photoaging . Positive_regulation IL1B MMP1 8594877 342043 [Interleukin-1 beta] *induces* gene expression and protein secretion in renal mesangial cells . Positive_regulation IL1B MMP1 9738019 531816 Serotonin mediated production of by uterine smooth muscle cells *requires* interleukin-1alpha , but not [interleukin-1beta] . Positive_regulation IL1B MMP1 9821179 548097 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* or TIMP expression . Positive_regulation IL1B MMP10 10727770 678102 [IL-1beta] and TPA alone *induced* activity in HIG-82 cells . Positive_regulation IL1B MMP10 10895370 711585 In support of this result , [IL-1 beta] stimulation *induced* the expression of membrane type matrix-metalloproteinase ( ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation IL1B MMP10 22792188 2628361 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B MMP10 9821179 548098 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* or TIMP expression . Positive_regulation IL1B MMP11 10727770 678103 [IL-1beta] and TPA alone *induced* activity in HIG-82 cells . Positive_regulation IL1B MMP11 10895370 711586 In support of this result , [IL-1 beta] stimulation *induced* the expression of membrane type matrix-metalloproteinase ( ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation IL1B MMP11 22792188 2628362 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B MMP11 9821179 548099 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* or TIMP expression . Positive_regulation IL1B MMP12 10727770 678104 [IL-1beta] and TPA alone *induced* activity in HIG-82 cells . Positive_regulation IL1B MMP12 10895370 711587 In support of this result , [IL-1 beta] stimulation *induced* the expression of membrane type matrix-metalloproteinase ( ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation IL1B MMP12 18980250 1995274 Our results indicate that [IL-1beta] in chondrocytes *induces* the expression and activation of , which , in turn , augments MMP-9 expression and activation . Positive_regulation IL1B MMP12 22792188 2628363 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B MMP12 9821179 548100 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* or TIMP expression . Positive_regulation IL1B MMP13 10727770 678105 [IL-1beta] and TPA alone *induced* activity in HIG-82 cells . Positive_regulation IL1B MMP13 10895370 711588 In support of this result , [IL-1 beta] stimulation *induced* the expression of membrane type matrix-metalloproteinase ( ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation IL1B MMP13 11883937 919742 In OA chondrocytes , the type of complex discriminated two groups -- the low-OA chondrocytes , showing low basal levels and high *inducibility* of [IL-1beta] stimulation ( complex 1 ) , and the high-OA chondrocytes with high collagenase-3 basal levels and low IL-1beta inducibility ( a faster migrating complex , designated complex 2 ) . Positive_regulation IL1B MMP13 12064845 953433 Of note , in OA chondrocytes , IL-17 and [IL-1beta] *induced* production through AP-1 occurred with differential protein complexes : IL-17 stimulation resulted in FosB activation , while IL-1beta stimulated c-Fos . Positive_regulation IL1B MMP13 12064845 953440 We demonstrated that IL-17 and [IL-1beta] *induced* production in OA chondrocytes mainly through AP-1 mediated transcriptional activity but with differential protein complexes , suggesting that some AP-1 proteins play a pivotal role in the different cytokine responses in terms of collagenase-3 production . Positive_regulation IL1B MMP13 12096844 961154 In primary culture of Cbfa1-/- chondrocytes , transforming growth factor (TGF) beta1 , platelet derived growth factor ( PDGF ) , [interleukin (IL)-1beta] , and thyroid hormone ( T3 ) *induced* osteopontin and expression . Positive_regulation IL1B MMP13 14634122 1170896 [IL-1beta] and TNF-alpha *stimulated* FLSC extracellular signal regulated kinase ( ERK ) activation as well as release . Positive_regulation IL1B MMP13 15950496 1434323 In both cell systems matrix metalloproteinase-1 (MMP-1) , MMP-3 and were strongly *induced* by [IL-1beta] , without significant induction of MMP-2 . Positive_regulation IL1B MMP13 15979654 1459106 expression *increased* markedly in the presence of [IL-1beta] on day 1 of culture , but decreased markedly after day 7 . Positive_regulation IL1B MMP13 16399619 1513035 In human primary chondrocytes , the production of and -1 ( MMP-13 and -1 ) and prostaglandin E2 ( PGE2 ) was *induced* by [interleukin-1beta] . Positive_regulation IL1B MMP13 16549373 1582328 [IL-1beta] and TNFalpha strongly *induced* the expression of in SW1353 cells and HACs , whereas only TNFalpha was found to induce the expression of these two MMPs in JJ012 cells . Positive_regulation IL1B MMP13 18433786 1908056 [Interleukin-1beta] significantly *induced* ( p < 0.01 ) matrix metalloproteinase-1 , 3 , 10 and 13 protein production , endogenous activity ( 12-fold ) and matrix metalloproteinase-13 mRNA expression ( 11.2-fold ) through a Ca ( 2+ ) independent mechanism in cultured fibroblasts . Positive_regulation IL1B MMP13 19248089 2045028 was *induced* by [IL-1beta] in a NF-kappaB dependent manner . Positive_regulation IL1B MMP13 22792188 2628364 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B MMP13 9821179 548101 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* or TIMP expression . Positive_regulation IL1B MMP14 10727770 678106 [IL-1beta] and TPA alone *induced* activity in HIG-82 cells . Positive_regulation IL1B MMP14 10895370 711589 In support of this result , [IL-1 beta] stimulation *induced* the expression of membrane type matrix-metalloproteinase ( ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation IL1B MMP14 22792188 2628365 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B MMP14 9821179 548102 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* or TIMP expression . Positive_regulation IL1B MMP15 10727770 678107 [IL-1beta] and TPA alone *induced* activity in HIG-82 cells . Positive_regulation IL1B MMP15 10895370 711590 In support of this result , [IL-1 beta] stimulation *induced* the expression of membrane type matrix-metalloproteinase ( ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation IL1B MMP15 22792188 2628366 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B MMP15 9821179 548103 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* or TIMP expression . Positive_regulation IL1B MMP16 10727770 678108 [IL-1beta] and TPA alone *induced* activity in HIG-82 cells . Positive_regulation IL1B MMP16 10895370 711591 In support of this result , [IL-1 beta] stimulation *induced* the expression of membrane type matrix-metalloproteinase ( ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation IL1B MMP16 22792188 2628367 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B MMP16 9821179 548104 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* or TIMP expression . Positive_regulation IL1B MMP17 10727770 678109 [IL-1beta] and TPA alone *induced* activity in HIG-82 cells . Positive_regulation IL1B MMP17 10895370 711592 In support of this result , [IL-1 beta] stimulation *induced* the expression of membrane type matrix-metalloproteinase ( ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation IL1B MMP17 22792188 2628368 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B MMP17 9821179 548105 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* or TIMP expression . Positive_regulation IL1B MMP19 10727770 678110 [IL-1beta] and TPA alone *induced* activity in HIG-82 cells . Positive_regulation IL1B MMP19 10895370 711593 In support of this result , [IL-1 beta] stimulation *induced* the expression of membrane type matrix-metalloproteinase ( ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation IL1B MMP19 22792188 2628369 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B MMP19 9821179 548106 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* or TIMP expression . Positive_regulation IL1B MMP2 10727770 678111 [IL-1beta] and TPA alone *induced* activity in HIG-82 cells . Positive_regulation IL1B MMP2 10895370 711572 however , [IL-1 beta] stimulation *induced* the secretion of as an active form from rheumatoid osteoblasts . Positive_regulation IL1B MMP2 10895370 711594 In support of this result , [IL-1 beta] stimulation *induced* the expression of membrane type matrix-metalloproteinase ( ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation IL1B MMP2 10895370 711618 These results suggest that [IL-1 beta] *induces* activation in part by up-regulating MT-MMP expression and represents a new mechanism for cytokine mediated articular destruction in RA . Positive_regulation IL1B MMP2 11480246 843586 TNF-alpha and [IL-1 beta] *induced* increases in the concentrations of MMP-1 , MMP-3 , and MMP-9 , but not in or tissue inhibitor of matrix metalloproteinase ( TIMP ) -1 or -2 . Positive_regulation IL1B MMP2 11811504 892760 As anticipated , [IL-1beta] *induced* a marked release of , MMP-3 , and TIMP-1 , but no variation for TIMP-2 was seen . Positive_regulation IL1B MMP2 16987994 1692462 [Interleukin-1beta] *increases* expression and activity of in cardiac microvascular endothelial cells : role of PKCalpha/beta1 and MAPKs . Positive_regulation IL1B MMP2 22792188 2628370 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B MMP2 9821179 548107 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* or TIMP expression . Positive_regulation IL1B MMP20 10727770 678112 [IL-1beta] and TPA alone *induced* activity in HIG-82 cells . Positive_regulation IL1B MMP20 10895370 711595 In support of this result , [IL-1 beta] stimulation *induced* the expression of membrane type matrix-metalloproteinase ( ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation IL1B MMP20 22792188 2628371 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B MMP20 9821179 548108 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* or TIMP expression . Positive_regulation IL1B MMP21 10727770 678099 [IL-1beta] and TPA alone *induced* activity in HIG-82 cells . Positive_regulation IL1B MMP21 10895370 711582 In support of this result , [IL-1 beta] stimulation *induced* the expression of membrane type matrix-metalloproteinase ( ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation IL1B MMP21 22792188 2628336 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B MMP21 9821179 548095 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* or TIMP expression . Positive_regulation IL1B MMP24 10727770 678113 [IL-1beta] and TPA alone *induced* activity in HIG-82 cells . Positive_regulation IL1B MMP24 10895370 711596 In support of this result , [IL-1 beta] stimulation *induced* the expression of membrane type matrix-metalloproteinase ( ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation IL1B MMP24 22792188 2628372 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B MMP24 9821179 548109 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* or TIMP expression . Positive_regulation IL1B MMP25 10727770 678096 [IL-1beta] and TPA alone *induced* activity in HIG-82 cells . Positive_regulation IL1B MMP25 10895370 711579 In support of this result , [IL-1 beta] stimulation *induced* the expression of membrane type matrix-metalloproteinase ( ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation IL1B MMP25 22792188 2628333 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B MMP25 9821179 548092 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* or TIMP expression . Positive_regulation IL1B MMP26 10727770 678097 [IL-1beta] and TPA alone *induced* activity in HIG-82 cells . Positive_regulation IL1B MMP26 10895370 711580 In support of this result , [IL-1 beta] stimulation *induced* the expression of membrane type matrix-metalloproteinase ( ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation IL1B MMP26 22792188 2628334 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B MMP26 9821179 548093 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* or TIMP expression . Positive_regulation IL1B MMP27 10727770 678098 [IL-1beta] and TPA alone *induced* activity in HIG-82 cells . Positive_regulation IL1B MMP27 10895370 711581 In support of this result , [IL-1 beta] stimulation *induced* the expression of membrane type matrix-metalloproteinase ( ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation IL1B MMP27 22792188 2628335 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B MMP27 9821179 548094 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* or TIMP expression . Positive_regulation IL1B MMP28 10727770 678100 [IL-1beta] and TPA alone *induced* activity in HIG-82 cells . Positive_regulation IL1B MMP28 10895370 711583 In support of this result , [IL-1 beta] stimulation *induced* the expression of membrane type matrix-metalloproteinase ( ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation IL1B MMP28 22792188 2628337 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B MMP28 9821179 548096 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* or TIMP expression . Positive_regulation IL1B MMP3 10727770 678114 [IL-1beta] and TPA alone *induced* activity in HIG-82 cells . Positive_regulation IL1B MMP3 10895370 711597 In support of this result , [IL-1 beta] stimulation *induced* the expression of membrane type matrix-metalloproteinase ( ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation IL1B MMP3 11174072 763237 MMP-3 was found to be the most abundant transcript , [IL-1beta] *induced* a 12-fold upregulation of levels compared to control , and 7-fold of TSG-6 . Positive_regulation IL1B MMP3 12384923 999425 Expression of was higher in vitro than in vivo and was *up-regulated* by [IL-1beta] . Positive_regulation IL1B MMP3 12825130 1104467 In human colonic SEMFs , MMP-3 secretion and mRNA expression were *induced* by IL-17 , [IL-1beta] , and TNF-alpha . Positive_regulation IL1B MMP3 15383690 1299071 Expression of MMP-1 and mRNAs was *induced* by [IL-1beta] . Positive_regulation IL1B MMP3 15950496 1434324 In both cell systems matrix metalloproteinase-1 (MMP-1) , and MMP-13 were strongly *induced* by [IL-1beta] , without significant induction of MMP-2 . Positive_regulation IL1B MMP3 17198194 1680598 In human pancreatic myofibroblasts , secretion and mRNA expression were *induced* by interleukin (IL)-17 , [IL-1beta] , and tumor necrosis factor (TNF) -alpha , respectively . Positive_regulation IL1B MMP3 17940116 1849317 We hypothesized that [IL-1beta] and TNF-alpha may *induce* matrix metalloproteinase (MMP)-1 and activity to promote PTD by degrading decidual and fetal membranes and cervical extracellular matrix . Positive_regulation IL1B MMP3 20511551 2276909 The inhibition of , -8 , or -9 significantly reduced NO and reactive oxygen species levels and *suppressed* the expression of TNF-alpha and [IL-1beta] . Positive_regulation IL1B MMP3 22792188 2628373 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B MMP3 9821179 548110 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* or TIMP expression . Positive_regulation IL1B MMP7 10727770 678115 [IL-1beta] and TPA alone *induced* activity in HIG-82 cells . Positive_regulation IL1B MMP7 10895370 711598 In support of this result , [IL-1 beta] stimulation *induced* the expression of membrane type matrix-metalloproteinase ( ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation IL1B MMP7 22792188 2628374 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B MMP7 9162049 431895 [Interleukin-1beta] secreted from monocytic cells *induces* the expression of in the prostatic cell line LNCaP . Positive_regulation IL1B MMP7 9821179 548111 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* or TIMP expression . Positive_regulation IL1B MMP8 10727770 678116 [IL-1beta] and TPA alone *induced* activity in HIG-82 cells . Positive_regulation IL1B MMP8 10895370 711599 In support of this result , [IL-1 beta] stimulation *induced* the expression of membrane type matrix-metalloproteinase ( ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation IL1B MMP8 22792188 2628375 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B MMP8 9821179 548112 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* or TIMP expression . Positive_regulation IL1B MMP9 10547161 564709 Studies with cycloheximide , a protein synthesis inhibitor , demonstrated that de novo protein synthesis is required for [IL-1beta] *induced* expression . Positive_regulation IL1B MMP9 10727770 678117 [IL-1beta] and TPA alone *induced* activity in HIG-82 cells . Positive_regulation IL1B MMP9 10895370 711600 In support of this result , [IL-1 beta] stimulation *induced* the expression of membrane type matrix-metalloproteinase ( ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation IL1B MMP9 12387824 999852 [IL-1beta] *induces* via reactive oxygen species and NF-kappaB in murine macrophage RAW 264.7 cells . Positive_regulation IL1B MMP9 17311279 1719255 [Interleukin-1beta] *induces* expression via p42/p44 MAPK , p38 MAPK , JNK , and nuclear factor-kappaB signaling pathways in human tracheal smooth muscle cells . Positive_regulation IL1B MMP9 22792188 2628376 Pharmacologic inhibitors and siRNA knockdown prevent [IL-1beta] *induction* of Egr-1 . Positive_regulation IL1B MMP9 8769830 379124 These results suggest that [IL-1 beta] *induced* via the stimulation of NF-kappa B pathway . Positive_regulation IL1B MMP9 8769830 379126 This inhibitor dose dependently suppressed the expression of , as well as the *activation* of the kappa B site by [IL-1 beta] , indicating the involvement of tyrosine kinase in the stimulation of NF-kappa B . Positive_regulation IL1B MMP9 8892653 392141 TNF-alpha and [IL-1beta] selectively *induce* expression of <92-kDa gelatinase> by human macrophages . Positive_regulation IL1B MMP9 9821179 548113 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* or TIMP expression . Positive_regulation IL1B MOK 18599158 2208588 We show here that : ( 1 ) S100B also stimulates AP-1 transcriptional activity in microglia via dependent activation of JNK; (2) S100B *upregulates* [IL-1beta] and TNF-alpha expression in microglia via RAGE engagement ; Positive_regulation IL1B MOK 18599158 2208598 and ( 3 ) *induced* upregulation of COX-2 , [IL-1beta] and TNF-alpha expression requires the concurrent activation of NF-kappaB and AP-1 . Positive_regulation IL1B MPL 16394010 1506053 *enhanced* the secretion of TNF-alpha , but not that of [IL-1beta] , whereas Escherichia coli-type lipid A ( natural source derived and chemically synthesized lipid A ) enhanced the secretion of both cytokines . Positive_regulation IL1B MPL 16394010 1506054 Although *enhanced* the levels of IL-1beta mRNA and [IL-1beta] precursor protein to levels similar to those induced by lipid A , IL-1beta precursor processing in MPL treated cells was much lower than that in E. coli-type lipid A-treated ones . Positive_regulation IL1B MPO 19067146 2024075 The TNBS treatment caused colon shortening , increased activity , *induced* [IL-1beta] , TNF-alpha , and IL-6 expression in the colon , activated NF-kappaB , and potentiated the GAG degrading activities of intestinal microflora . Positive_regulation IL1B MST1 20561679 2285198 Furthermore , we found that unmodified *induced* [IL-1beta] production was depended on the sequence of reactive oxygen species ( ROS ) production , endosomal rupture , and subsequent activation of pro-inflammatory complex NLRP3 inflammasome . Positive_regulation IL1B MT-CO2 15529314 1355144 On the other hand , and Cr3+ ions *had* a weak stimulatory effect or no effect on [IL-1beta] and IL-6 , respectively , in both cultured and suspension cells . Positive_regulation IL1B MT-CO2 20397120 2240589 , but not hypoxia , induced a significant reduction in the release of TNF-alpha and IL-8 as well as a significant *increase* in the release of IL-10 and [IL-1 beta] within the first 4 h after incubation . Positive_regulation IL1B MT2A 10471781 642048 The time and pattern of induction was different , both IL-1alpha and [IL-1beta] *inducing* two peaks of MT-1 and MT-2 , with that of being much larger . Positive_regulation IL1B MTA1 19840651 2155224 Angelus *induced* [IL-1beta] releasing significantly more than the control . Positive_regulation IL1B MTA2 19840651 2155225 Angelus *induced* [IL-1beta] releasing significantly more than the control . Positive_regulation IL1B MTA3 19840651 2155223 Angelus *induced* [IL-1beta] releasing significantly more than the control . Positive_regulation IL1B MTX1 15385641 1300146 These results indicate that the inflammatory macrophage can assemble the necessary signaling components to initiate both regulated and lytic release of [IL-1beta] in *response* to . Positive_regulation IL1B MTX1 19100307 2024637 *activated* [IL-1beta] expression and induced the phosphorylation of various proteins in the p38 MAPK cascade , including TAK1 , MKK3/MKK6 , p38 MAPK , MAPKAPK2 , and HSP27 . Positive_regulation IL1B MUC1 12482999 1024567 [Interleukin-1beta] *induces* MUC2 gene expression and secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation IL1B MUC12 12482999 1024568 [Interleukin-1beta] *induces* MUC2 gene expression and secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation IL1B MUC13 12482999 1024569 [Interleukin-1beta] *induces* MUC2 gene expression and secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation IL1B MUC15 12482999 1024561 [Interleukin-1beta] *induces* MUC2 gene expression and secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation IL1B MUC16 12482999 1024562 [Interleukin-1beta] *induces* MUC2 gene expression and secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation IL1B MUC17 12482999 1024563 [Interleukin-1beta] *induces* MUC2 gene expression and secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation IL1B MUC19 12482999 1024560 [Interleukin-1beta] *induces* MUC2 gene expression and secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation IL1B MUC2 12391274 1007513 [Interleukin-1beta] *induces* and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells . Positive_regulation IL1B MUC2 12482999 1024570 [Interleukin-1beta] *induces* gene expression and mucin secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation IL1B MUC2 20062084 2225435 These differences can be attributed to specific cytokines , because TNF-alpha and [IL-1beta] *induced* but no MUC4 expression in gastric cancer cell lines . Positive_regulation IL1B MUC20 12482999 1024565 [Interleukin-1beta] *induces* MUC2 gene expression and secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation IL1B MUC21 12482999 1024564 [Interleukin-1beta] *induces* MUC2 gene expression and secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation IL1B MUC22 12482999 1024566 [Interleukin-1beta] *induces* MUC2 gene expression and secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation IL1B MUC4 12482999 1024571 [Interleukin-1beta] *induces* MUC2 gene expression and secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation IL1B MUC4 20062084 2225436 These differences can be attributed to specific cytokines , because TNF-alpha and [IL-1beta] *induced* MUC2 but no expression in gastric cancer cell lines . Positive_regulation IL1B MUC5AC 12391274 1007514 [Interleukin-1beta] *induces* MUC2 and synthesis through cyclooxygenase-2 in NCI-H292 cells . Positive_regulation IL1B MUC5AC 12690113 1099949 [Interleukin-1 beta] and tumor necrosis factor-alpha *induce* overexpression through a mechanism involving ERK/p38 mitogen activated protein kinases-MSK1-CREB activation in human airway epithelial cells . Positive_regulation IL1B MUC6 12482999 1024572 [Interleukin-1beta] *induces* MUC2 gene expression and secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation IL1B MUC7 12482999 1024573 [Interleukin-1beta] *induces* MUC2 gene expression and secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation IL1B MUC8 12482999 1024574 [Interleukin-1beta] *induces* MUC2 gene expression and secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation IL1B MVK 12384940 999449 To investigate whether the increased [interleukin-1beta (IL-1beta)] secretion in hyperimmunoglobulinemia D and periodic fever syndrome is *due* to the accumulation of , the substrate of the deficient enzyme , or the lack of its products , the isoprenoid compounds . Positive_regulation IL1B MYC 16980582 1616985 activation in beta cells rapidly *induces* expression and release of the proinflammatory cytokine [interleukin 1beta (IL-1beta)] . Positive_regulation IL1B MYD88 11160328 781695 These results indicate that is *essential* for IL-12 and [IL-1beta] production from Kupffer cells while their IL-18 secretion is mediated via activation of endogenous caspase-1 without de novo protein synthesis in a MyD88 independent fashion after stimulation with LPS . Positive_regulation IL1B MYD88 17032168 1630780 These studies support the hypothesis that the expression of IL-1beta requires both the *dependent* induction of IL-1beta mRNA and [pro-IL-1beta] as well as the MyD88 independent , Stat1 mediated processing of that gene product into active cytokine . Positive_regulation IL1B MYD88 19342688 2056849 The *role* and relative contribution of , IRAK1 , and TRAF6 adaptor proteins in [IL-1beta] regulation of aggrecanase-1 ( ADAMTS-4 ) is unknown . Positive_regulation IL1B MYD88 19783673 2147628 however , neutrophil recruitment , the localized production of [IL-1beta] , and the increase in circulating IL-6 *require* signaling , the IL-1R pathway , and the inflammasome components ICE ( IL-1beta converting enzyme ) , ASC ( apoptosis associated , speck-like protein containing CARD ) , and NALP3 . Positive_regulation IL1B MYD88 19819943 2164535 FFA induced [IL-1beta] and KC expression in mouse islets was completely *dependent* on the IL-1R/Toll-like receptor (TLR) docking protein and partly dependent on TLR2 and -4 . Positive_regulation IL1B MYLIP 19333945 2056487 This study shows that is intensely expressed in low-grade OA cartilage and that its expression is *induced* by stimulation of [IL-1beta] . Positive_regulation IL1B MYLIP 20086228 2226052 We found that [IL-1beta] and TNF-alpha *induce* the expression of , miR-34a , and miR-146a both in MIN6 cells and human pancreatic islets . Positive_regulation IL1B MYLK 18390750 1893375 In conclusion , our data indicate that the [IL-1beta] increase in Caco-2 TJ permeability was *mediated* by an increase in expression and activity . Positive_regulation IL1B NA 11153595 761130 ( 5 mM ) also *enhanced* LPS induced [IL-1beta] release from THP-1 cells ( p < 0.001 ) . Positive_regulation IL1B NA 11153595 761131 In addition , treatment of cells with cycloheximide , an inhibitor of protein synthesis , inhibited the *mediated* [IL-1beta] release . Positive_regulation IL1B NA 12127835 966193 Interestingly , *increased* the [IL-1beta] and iNOS mRNA levels but did not significantly modify COX-2 mRNA expression . Positive_regulation IL1B NA 18096486 1838279 also *resulted* in significantly fewer macrophages , lymphocytes and neutrophils as well as [IL-1 beta] , keratinocyte cytokine ( KC ) , monocyte chemoattractant protein (MCP)-1 and IL-6 levels in BAL taken after reperfusion . Positive_regulation IL1B NAALADL1 15683451 1370624 The lymph node homing chemokine receptor CCR-7 expression was induced by TNF-alpha + [IL-1beta] + IL-6 + prostaglandin E2 but was not *induced* by Poly + TNF-alpha . Positive_regulation IL1B NAMPT 17237424 1690067 In CD14 ( + ) monocytes , *induces* the production of [IL-1beta] , TNF-alpha , and especially IL-6 . Positive_regulation IL1B NANOS2 10779013 687126 The activity , assessed by nitrite accumulation , was absent from untreated cultures but was *induced* by [interleukin-1beta] and interferon-gamma acting synergistically . Positive_regulation IL1B NANOS2 11286988 799900 In monolayers , [interleukin-1beta (IL-1beta)] *induced* COX-2 and expression in a dose- and time dependent manner , to produce high prostaglandin E ( 2 ) ( PGE ( 2 ) ) and nitrite ( NO ( 2 ) ( - ) ) levels in an apparently coordinated fashion . Positive_regulation IL1B NANOS2 12427659 1014768 Myocardial tumor necrosis factor , [interleukin-1beta (IL-1beta)] , and *induction* was measured before and 6 hours after LPS challenge . Positive_regulation IL1B NBL1 7594493 334774 Finally , [IL-1 beta] at high doses also *induced* iNOS mRNA and significant NO2- + production in cultures of primary human hepatocytes . Positive_regulation IL1B NCAM1 16718462 1584928 We suggest that signalling through FGFR is *required* for efficient [IL-1beta] pro-apoptotic signalling by facilitating IL-1beta induced MAPK activation downstream of the NF-kappaB-MAPK branching point . Positive_regulation IL1B NCAM2 16718462 1584929 We suggest that signalling through FGFR is *required* for efficient [IL-1beta] pro-apoptotic signalling by facilitating IL-1beta induced MAPK activation downstream of the NF-kappaB-MAPK branching point . Positive_regulation IL1B NCL 19060367 2000032 [ *Role* of cell-surface in lipopolysaccharide stimulated expression and secretion of TNF-alpha and [IL-1beta] ] . Positive_regulation IL1B NCL 19060367 2000038 To explore the *role* of cell-surface in lipopolysaccharide (LPS) stimulated expression and secretion of TNF-alpha and [IL-1beta] in human THP-1 monocytes . Positive_regulation IL1B NELFCD 20153259 2248510 Using PBMC from healthy individuals , we show that monocytes differentiated with IL-15 ( IL15-DC ) produced [IL-1beta] , IL-6 , IL-15 , IL-23 , TNFalpha and CCL20 in *response* to pepsin-trypsin digested gliadin (PTG) and activated contact dependent Th17 and responses from autologous CD4 ( + ) T cells . Positive_regulation IL1B NF1 15327898 1287572 Site directed mutagenesis and gel shift analyses revealed that PMA and [IL-1beta] strongly *induced* binding to the JC virus enhancer region , increasing transcriptional activity of the viral early promoter . Positive_regulation IL1B NFATC1 19052845 2029720 ADAMTS9 *activation* by [interleukin 1 beta] via in OUMS-27 chondrosarcoma cells and in human chondrocytes . Positive_regulation IL1B NFKB1 10074208 594747 In contrast , infection with EZ did not block *activation* of the transcription factor by [IL-1beta] . Positive_regulation IL1B NFKB1 10089132 600012 PD 098059 , a selective inhibitor of the ERK activating kinase MEK1 , had no effect on IL-1beta induced MCP-1 mRNA or protein levels , or on [IL-1beta] *activation* of . Positive_regulation IL1B NFKB1 10232679 611400 Treatment with N ( G ) -nitro-L-arginine methyl ester ( L-NAME ) did not affect initial *activation* of by [IL-1beta/TNF-alpha] , but unveiled an inhibitory effect of NO generation on NF-kappaB activity after 4 h . Positive_regulation IL1B NFKB1 10484338 643969 On the basis of previous work demonstrating nitric oxide ( NO ) -mediated inhibition of nuclear factor-kappaB (NF-kappaB) DNA binding , we hypothesized that NO downregulates *dependent* [interleukin-1beta (IL-1beta)] production in an ANA-1 macrophage model of lipopolysaccharide (LPS) stimulation . Positive_regulation IL1B NFKB1 10614986 575772 It has been shown that B1-receptor induction during inflammation involves [interleukin-1beta (IL-1beta)] production and *activation* of . Positive_regulation IL1B NFKB1 10619820 657341 Inhibition of by pyrrolidine dithiocarbamate *attenuated* [IL-1beta] and TNF-alpha synthesis . Positive_regulation IL1B NFKB1 10707928 673453 In PANC-1 cells , [IL-1beta] and TNF-alpha *induced* a rapid activation of , and TGF-beta1 enhanced this activation slightly . Positive_regulation IL1B NFKB1 10881930 709229 [IL-1beta] and TNF-alpha *induced* a rapid activation of in PANC-1 cells , and the increase in chemokine mRNA expression correlated with NF-kappaB activation . Positive_regulation IL1B NFKB1 10884313 709538 However , pretreatment with oATP downregulated *activation* of and AP-1 by [IL-1beta] or TNFalpha . Positive_regulation IL1B NFKB1 10936515 720687 Dexamethasone *inhibits* [IL-1 beta] gene expression in LPS stimulated RAW 264.7 cells by blocking and AP-1 activation . Positive_regulation IL1B NFKB1 11020244 737832 The p106 and p112 proteins bound to NF-kappaB , and their levels changed during the transient [interleukin-1beta] *activation* of in HT-29 cells . Positive_regulation IL1B NFKB1 11104703 756499 Taken together , these findings indicate that , by using a proteasome dependent mechanism , [IL-1beta] concomitantly *induces* activation and dephosphorylates IL-6 activated STAT1 ; Positive_regulation IL1B NFKB1 11264769 796660 An inhibition of by pyrrolidine dithiocarbamate *attenuated* [IL-1beta] and TNF-alpha synthesis . Positive_regulation IL1B NFKB1 11274229 797583 These data suggested that ( 1 ) constitutive and [IL-1beta-inducible] expression of MCP-1 was differently *regulated* by AP-1 and and ( 2 ) t-RA inhibited selectively the constitutive expression of MCP-1 via intervention in the AP-1 pathway . Positive_regulation IL1B NFKB1 11466367 839961 Additional data are provided indicating that the *activation* of by [IL-1beta] is also responsible for the inhibition of other IL-6-inducible genes , such as the alpha(1)-antichymotrypsin gene as well as the suppressor of cytokine signaling 3 gene , suggesting a more general relevance of this mechanism for transcriptional regulation . Positive_regulation IL1B NFKB1 11698503 878183 In naive cells , LPS , TNF-alpha , and [IL-1beta] *induced* IkappaBalpha degradation , kinase phosphorylation , and DNA binding . Positive_regulation IL1B NFKB1 11742864 887436 [IL-1beta] *induced* a rapid and transient activation of , followed by a prolonged activation of NF-kappaB that was required to induce iNOS expression . Positive_regulation IL1B NFKB1 11916194 925463 The inhibition of activation markedly *blocked* both [IL-1beta-] and TNF-alpha induced IL-8 and MCP-1 mRNA expression , but did not affect MMP-1 mRNA expression . Positive_regulation IL1B NFKB1 11930628 894638 Enhancement of activity of and AP-1 may positively *regulate* the production of IL-8 and [IL-1 beta] in the airflow obstruction . Positive_regulation IL1B NFKB1 11996950 939209 In addition , [IL-1beta] *induced* activation in VSMC , an effect that was increased by the addition of beta-VLDL . Positive_regulation IL1B NFKB1 12021045 942765 In this study , we investigated the possible *role* of the in [IL-1beta] signaling , leading to the expression of COX-2 in human amnion cell culture . Positive_regulation IL1B NFKB1 12219013 986608 The 2 groups of mice were analyzed for serum levels of interferon-gamma , tumor necrosis factor-alpha , and [interleukin-1beta] as well as *activation* of and STAT1 , 2 proinflammatory transcription factors . Positive_regulation IL1B NFKB1 12421347 1013463 In comparison , [IL-1beta] *induced* the release of PGE2 , IL-6 and activated , p38 , JNK and ERK1/2 in mixed glial cultures , but failed to induce any of these responses in microglial cell cultures . Positive_regulation IL1B NFKB1 12509805 1038770 Finally , [IL-1beta] and TNF-alpha *induced* degradation of 's bound inhibitory protein , IkappaB-alpha , leading to translocation of NF-kappaB into the nucleus . Positive_regulation IL1B NFKB1 12528110 1048602 Activation of was *induced* by [IL-1 beta] , but not by MIF . Positive_regulation IL1B NFKB1 12594338 1064339 To further substantiate that the observed [IL-1 beta] *induction* of the human NK-1R gene is regulated via a transcriptional event through this NF-kappa B site on the NK-1R gene promoter , we transfected THP-1 cells with a luciferase promoter-reporter construct containing the 5 ' promoter region of the human NK-1R gene . Positive_regulation IL1B NFKB1 12676746 1076847 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that mitogen activated protein (MAP) kinase signaling and activation are *involved* in IL-1beta induced IL-6 production . Positive_regulation IL1B NFKB1 12839952 1108184 Supershift assay indicated that the two NF-kappa B subunits , p65 and p50 , were involved in *activation* of complex by [IL-1 beta] stimulation . Positive_regulation IL1B NFKB1 12898518 1118510 Our results suggest that activation in PIMs followed by phagocytizing lipopolysaccharide *resulted* in the up-regulation of TNF-alpha , [IL-1beta] , IL-6 , IL-8 , and COX-2 , which could be alleviated by dexamethasone . Positive_regulation IL1B NFKB1 14527367 1148357 mRNA expression of proinflammatory cytokines ( [IL-1 beta] , IL-6 , TNF-alpha , and MCP-1 ) and *activation* of of HMC were measured using Reverse transcription-polymerase chain reaction ( RT-PCR ) and electrophoretic mobility shift assay ( EMSA ) respectively . Positive_regulation IL1B NFKB1 14581482 1186939 Thus , although activation was *essential* for [interleukin-1beta] induction of each of the proteins studied , gene expression was differentially regulated by ERK and by the duration of NF-kappaB activation . Positive_regulation IL1B NFKB1 14652683 1173705 The analysis of IkappaB degradation and NF-kappaB translocation revealed that hypoxia did not affect [IL-1beta] *activation* of . Positive_regulation IL1B NFKB1 14670622 1188985 These results suggest that AAF *inhibits* [IL-1beta] gene expression by blocking activation . Positive_regulation IL1B NFKB1 14985981 1236664 The *activation* of by [IL-1beta] was maximal at 20 min and declined thereafter . Positive_regulation IL1B NFKB1 15001568 1236969 The inhibitory effect of angiotensin II on iNOS expression was associated with a down-regulation of the sustained *activation* of extracellular signal regulated kinase ( ERK ) and by [interleukin-1beta] , whereas the effect on VCAM-1 was independent of ERK activation . Positive_regulation IL1B NFKB1 15039421 1251224 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of [pro-IL-1beta] , and RIP2 dependent *activation* of and p38 MAPK mediated by the caspase recruitment domain . Positive_regulation IL1B NFKB1 15044702 1228279 Expression of [IL-1beta] in AF macrophages and *activation* of in the maternal uterus increased with the gestational increase in SP-A . Positive_regulation IL1B NFKB1 15063239 1230850 Our results suggest that elevated activation of , at least in part , *contributes* to the dysregulated expression of [IL-1beta] and iNOS in the lungs of senescent animals . Positive_regulation IL1B NFKB1 15146413 1247763 The mRNA up-regulation of IL-8 and [IL-1beta] by MIF was *inhibited* by 2 tyrosine kinase inhibitors , a protein kinase C ( PKC ) inhibitor , an activator protein 1 (AP-1) inhibitor , and by an inhibitor . Positive_regulation IL1B NFKB1 15240151 1270118 Interestingly , [IL-1beta] *induced* activation in A549 cells , which was shown by increased nuclear translocation of p65 NF-kappaB and degradation of IkappaB-alpha . Positive_regulation IL1B NFKB1 15662752 1350342 It became known , that oxidized LDL can inhibit LPS induced binding of the NF-kappaB to DNA and the subsequent expression of TNF-alpha and [interleukin-1beta] in macrophages as well as oxidized LDL modulates *activation* of in mononuclear phagocytes by altering the degradation of I-kappaBs . Positive_regulation IL1B NFKB1 15749024 1379451 Recombinant mouse [IL-1beta] *induced* strong activation of ERK1/2 , p38 , JNK and , and significant release of IL-6 and PGE2 , which was blocked by IL-1ra . Positive_regulation IL1B NFKB1 15980221 1424666 The *activation* of by [IL-1beta] was markedly inhibited by both triptolide and dexamethasone , whereas the activity of AP-1 was not affected by either agent . Positive_regulation IL1B NFKB1 16106402 1498851 Ursodeoxycholic acid inhibits [interleukin 1 beta] [ corrected ] and deoxycholic acid induced *activation* of and AP-1 in human colon cancer cells . Positive_regulation IL1B NFKB1 16148608 1455210 [Interleukin-1beta] *induced* activation in vascular smooth muscle cells , and the addition of GGA further inhibited this NF-kappaB activation . Positive_regulation IL1B NFKB1 16258248 1477784 It also inhibited NF-IL6- and induced *activation* of [IL-1beta] , with IC50 values of 78 nM and 1.6 microM , respectively , revealing a potent inhibitory effect on NF-IL6 . Positive_regulation IL1B NFKB1 16297883 1502771 Dioscorin also stimulated multiple signaling molecules ( , ERK , JNK , and p38 ) and *induced* the expression of cytokines ( TNF-alpha , [IL-1beta] , and IL-6 ) in murine RAW 264.7 macrophages . Positive_regulation IL1B NFKB1 16339279 1539611 Chromatin immunoprecipitation analysis revealed [IL-1beta] *induced* binding of to the PR promoter . Positive_regulation IL1B NFKB1 16399630 1513045 These results suggest that CHL *inhibits* [IL-1beta] production in macrophages stimulated with LPS at transcriptional level by blocking the phosphorylation of p38 and by suppressing the activation of transcription factors , , NF-IL6 , and AP-1 . Positive_regulation IL1B NFKB1 16556731 1589299 Both cytokines induced a prolonged ( up to 48 h ) and stable NF-kappaB activation in INS-1E cells , whereas [IL-1beta] *induced* an oscillatory activation in 208F cells . Positive_regulation IL1B NFKB1 16581045 1496464 Signal transduction studies revealed that [IL-1beta] and TNF-alpha stimulation *induced* phosphorylation in A549 cells , but antagonist inhibition of NFkappaB p50-p65 phosphorylation correlated with marked reduction of IL-1beta or TNF-alpha induced CCL28 expression . Positive_regulation IL1B NFKB1 16778360 1576826 However , both [IL-1beta] and IL-6 mRNA induction was *suppressed* by inhibitors . Positive_regulation IL1B NFKB1 16822942 1638582 In conclusion , in the ERK signaling cascade , RSK1 is a key component that directly phosphorylates IkappaBbeta and contributes to the persistent *activation* of by [IL-1beta] . Positive_regulation IL1B NFKB1 16858424 1625429 In HaCaT cells and in reconstructed human epidermis ( RHE ) , FasL triggered a *dependent* mRNA accumulation of inflammatory cytokines ( tumor necrosis factor-alpha , IL-6 , and [IL-1beta] ) , chemokines ( CCL2/MCP-1 , CXCL1/GROalpha , CXCL3/GROgamma , and CXCL8/IL-8 ) , and the adhesion molecule ICAM-1 . Positive_regulation IL1B NFKB1 17135302 1716730 ROS and but not LXR *mediate* [IL-1beta] signaling for the downregulation of ATP binding cassette transporter A1 . Positive_regulation IL1B NFKB1 17189835 1680273 Compared to wild-type mice , the obese mice exhibited higher levels of phosphorylation of these proteins , greater *activation* of , and higher levels of circulating proinflammatory cytokines , including TNF-alpha , [IL-1beta] and IL-6 , on UVB irradiation . Positive_regulation IL1B NFKB1 17227815 1703849 However , inhibition of the RhoA/Rho-kinase pathway did not attenuate the *activation* of by [IL-1beta] . Positive_regulation IL1B NFKB1 17473513 1738342 Mutations of cyropyrin lead to the persistent production of [IL-1beta] and *activation* of , followed by excessive inflammtory reactions . Positive_regulation IL1B NFKB1 17501665 1783813 In contrast , was not *essential* for [IL-1beta] induction of OPG . Positive_regulation IL1B NFKB1 18300858 1873449 However , the high concentration of D-glucose did increase iNOS expression in response to low concentrations of [IL-1beta] ( 2.5 and 5 ng/ml ) , as well as the IL-1beta induced *activation* of both ERK 1/2 and . Positive_regulation IL1B NFKB1 18433103 1920790 It was previously demonstrated that stevioside attenuates *dependent* TNF-alpha and [IL-1beta] synthesis in LPS stimulated monocytes . Positive_regulation IL1B NFKB1 18456659 1933009 TAB4 mutated at Phe-Pro dominantly interfered with [IL-1beta] *activation* of involving IKK dependent but not p38 MAPK dependent signaling . Positive_regulation IL1B NFKB1 18547651 1940570 The activation of was *followed* by increased mRNA expression of TNF-alpha and [IL-1beta] peaking at about 20 h . Positive_regulation IL1B NFKB1 18599158 2208597 and ( 3 ) S100B/RAGE induced upregulation of COX-2 , [IL-1beta] and TNF-alpha expression *requires* the concurrent activation of and AP-1 . Positive_regulation IL1B NFKB1 19067146 2024076 The TNBS treatment caused colon shortening , increased myeloperoxidase activity , *induced* [IL-1beta] , TNF-alpha , and IL-6 expression in the colon , activated , and potentiated the GAG degrading activities of intestinal microflora . Positive_regulation IL1B NFKB1 19454703 2084578 In direct correlation with the increased viral internalization , antiviral Abs amplified the innate immune response to adenovirus as determined by the expression of *dependent* genes , type I IFNs , and caspase dependent [IL-1beta] maturation . Positive_regulation IL1B NFKB1 19474209 2085592 In addition , the A. fumigatus antigens induced production of [IL-1beta] and IL-10 in supernatants of corneal epithelial cells was also *attenuated* by inhibitor . Positive_regulation IL1B NFKB1 19521662 2108902 Transforming growth factor-beta activated kinase 1 ( TAK1 ) is a serine/threonine protein kinase that is critically involved in the *activation* of by tumor necrosis factor ( TNFalpha ) , [interleukin-1beta (IL-1beta)] and TLR ligands . Positive_regulation IL1B NFKB1 19648113 2143236 Injury induced platelet derived growth factor receptor-alpha expression mediated by [interleukin-1beta (IL-1beta)] release and cooperative *transactivation* by and ATF-4 : IL-1beta facilitates HDAC-1/2 dissociation from promoter . Positive_regulation IL1B NFKB1 19915568 2189965 Its production is tightly controlled by transcription of [Il1b] *dependent* on the transcription factor and subsequent processing of pro-IL-1 beta by an inflammasome . Positive_regulation IL1B NFKB1 19929594 2171913 IFN-gamma does not affect the transient *activation* of classical by [IL-1beta] and synergistic induction of ip-10 expression by IFN-gamma and IL-1beta occurs even after the activation of classical NF-kappaB has returned to basal levels . Positive_regulation IL1B NFKB1 20145375 2280995 [IL-1beta] ( 4 ng/ml , 10 min ) *induced* phosphorylation of , JNK , and ERK . Positive_regulation IL1B NFKB1 20181058 2222748 [IL-1beta] potently *induced* activation in CaCo-2 cells , but did not induce TLR-4 expression . Positive_regulation IL1B NFKB1 20369226 2261619 Saturated-fatty-acid induced activation and endoplasmic reticulum stress may *contribute* to [IL-1beta] production and mild islet inflammation in type 2 diabetes . Positive_regulation IL1B NFKB1 20398663 2293931 In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6 , [interleukin-1beta] , and tumor necrosis factor alpha ) and *activation* of MAPK and in Pirb-/- macrophages following bacterial activation . Positive_regulation IL1B NFKB1 23136298 2729440 As expected , [IL1B] *induced* transcriptional activity . Positive_regulation IL1B NFKB1 24009751 2836893 In this study , the probable pathway by which [IL1B] *induces* and affects gastrin expression has been elucidated . Positive_regulation IL1B NFKB1 7545088 318476 Here we demonstrate that [IL-1 beta] *induces* nuclear translocation of in human umbilical vein endothelial cells , followed by induction of cell surface expression of E-selectin , intercellular adhesion molecule-1 , and vascular adhesion molecule 1 , and subsequently augments adhesion of those cancer cells expressing sialyl Lewis X antigen , a ligand to E-selectin . Positive_regulation IL1B NFKB1 8021507 263078 *regulates* [IL-1 beta] transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site . Positive_regulation IL1B NFKB1 8074713 270567 In human astrocytoma and neuroblastoma cell lines tumour necrosis factor alpha (TNF alpha) and [interleukin 1 beta (IL-1 beta)] *induced* and an additional KB-specific protein of approximately 80 K to bind the HIV-1 enhancer . Positive_regulation IL1B NFKB1 8144314 242474 Therefore , we investigated whether cyclic AMP , protein kinase A and are *involved* in the induction of [IL-1 beta] release by human peripheral blood monocyte derived macrophages ( HPBM ) stimulated with a specific IL-1 beta inducer , 9-hydroxyoctadecadienoic acid ( 9-HODE ) . Positive_regulation IL1B NFKB1 8579596 350558 [IL-1 beta] rapidly *induced* the translocation of in rat mesangial cells . Positive_regulation IL1B NFKB1 8809309 383094 The aim now was to investigate whether recombinant ( r ) [IL-1 beta] *induces* the stimulation of and its inhibitor proteins in human gingival fibroblasts and to understand if inhibition of its activity affects collagenase gene expression . Positive_regulation IL1B NFKB1 8977194 408704 IL-1beta stimulated NF-kappaB nuclear translocation and *dependent* [IL-1beta] and IL-8 expression in both Caco-2 and HT-29 cells as assayed by electrophoretic mobility shift assay , immunofluorescence , kappaB-luciferase transfection , reverse transcriptase-PCR analysis and ELISA . Positive_regulation IL1B NFKB1 9079634 420544 *Role* of in tumor necrosis factor-alpha and [interleukin-1beta] regulation . Positive_regulation IL1B NFKB1 9332715 457648 The oxidative stress responsive transcription factor consists of a p50 ( 50 kDa ) and p65/RelA ( 65 kDa ) component and can be *activated* in vitro by TNF alpha , [IL1 beta] , hydrogen peroxide and oxygen radicals . Positive_regulation IL1B NFKB1 9510209 491887 The *role* of activation in BK-induced [IL-1beta] synthesis was demonstrated by the ability of BK to stimulate increased chloramphenicol acetyltransferase (CAT) activity in A549 cells transfected with a reporter plasmid containing three kappaB enhancers from the IL-1beta gene , while deletion of the kappaB enhancer sequences eliminated BK-stimulated CAT activity . Positive_regulation IL1B NFKB1 9681388 521078 Interleukin-1 mediated febrile responses in mice and [interleukin-1 beta] *activation* of in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B NFKB1 9758209 536001 These results provide convincing evidence that may *mediate* the [IL-1beta] stimulation of PGHS-2 gene expression as well as the dexamethasone inhibition of the IL-1beta induction process in WISH cells . Positive_regulation IL1B NFKB1 9759860 536568 *Activation* of by [IL-1beta] was markedly less sensitive to both cPLA2 and sPLA2 inhibitors . Positive_regulation IL1B NFKB1 9798528 543546 Nuclear factor in myocardium : developmental expression of subunits and *activation* by [interleukin-1 beta] in cardiac myocytes in vitro . Positive_regulation IL1B NFKBIA 10638662 660328 [IL-1beta] stimulation of cultured epithelial cells *induces* the degradation of and the consequent nuclear translocation of NF-lambdaB , a critical proinflammatory transcription factor in the mucosal host immune response . Positive_regulation IL1B NFKBIA 11275558 797836 Western blot analyses involving anti-IkappaB-alpha and anti-phospho IkappaB-alpha antibodies showed that [IL-1beta] *induced* transient degradation of preceded by the rapid appearance of phosphorylated IkappaB-alpha , both of which were markedly blocked by N2733 . Positive_regulation IL1B NFKBIA 11698503 878184 In naive cells , LPS , TNF-alpha , and [IL-1beta] *induced* degradation , kinase phosphorylation , and NF-kappaB DNA binding . Positive_regulation IL1B NFKBIA 16249450 1471738 Expression of the NF-kappaB dependent genes and monocyte chemoattractant protein (MCP)-1 was *induced* in human islets by [IL-1beta] but not by high glucose . Positive_regulation IL1B NFKBIA 19278584 2046339 The IKK-2 inhibitor , SC-514 , inhibited [IL-1beta] *induced* protein activity , blocked p65 nuclear translocation , caused a significant reduction in IL-1beta induced DNA binding activity for p65 and ICAM-1 mRNA expression , and suppressed ICAM-1 expression on A549 cell surface ( all P < 0.01 ) . Positive_regulation IL1B NFKBIA 9812920 545990 Western blot analysis using anti-IkappaB-alpha and anti-phospho-IkappaB-alpha antibodies revealed that [IL-1beta] *induced* a transient degradation of preceded by a rapid appearance of phosphorylated IkappaB-alpha , both of which were completely blocked by NOR3 . Positive_regulation IL1B NFKBIZ 12565889 1054343 , a new negative-regulator of nuclear factor-kappa B (NF-kappa B) , is strongly *induced* by lipopolysaccharide or [interleukin-1 beta] stimulation , but not by tumor necrosis factor-alpha . Positive_regulation IL1B NFKBIZ 19707556 2127269 Our results demonstrated that IL-18 , as well as [IL-1beta] , *induced* moderate expression in KG-1 cells . Positive_regulation IL1B NGF 8572657 349919 The increase in NGF temporally follows the increase in IL-1 beta , suggesting that the [IL-1 beta] up-regulation after trauma directly *induces* the increase in . Positive_regulation IL1B NGF 9833249 552021 Out data showed that [IL-1 beta] , but not TNF-alpha , *induces* an increase in levels , while concomitant injection of both cytokines enhances the effect of IL-1 beta on NGF presence . Positive_regulation IL1B NID1 18434122 1926372 [IL-1beta] or TNF-alpha alone *induced* increased secretion of type IV collagen , laminin-1 , and , all of which contributed to this upregulation . Positive_regulation IL1B NKX2-1 19076932 2024220 [IL-1beta] and IL-10 *induced* expression . Positive_regulation IL1B NLRC4 18566365 1929600 In this study we show that , in human and mouse macrophages , alum induced secretion of [IL-1beta] , IL-18 , and IL-33 is *mediated* by the NLR ( nucleotide binding domain leucine-rich repeat containing ) protein NLRP3 and its adaptor ASC , but not by . Positive_regulation IL1B NLRC4 19120480 2019403 In this review , we focus on the role of Nod1 and Nod2 in host defense and in particular discuss recent finding regarding the *role* of , Nlpr1 , and Nlrp3 inflammasomes in caspase-1 activation and subsequent release of proinflammatory cytokines such as [interleukin-1 beta] . Positive_regulation IL1B NLRP2 15456791 1342087 In gene transfer experiments *enhances* caspase-1 activation and [IL-1beta] secretion in collaboration with ASC . Positive_regulation IL1B NLRP3 14634131 1170923 We also show that expression of the PAAD/PYRIN family proteins pyrin or individually inhibits IL-1beta secretion but that coexpression of ASC with these proteins *results* in enhanced [IL-1beta] secretion . Positive_regulation IL1B NLRP3 15020601 1243434 *induced* [interleukin 1beta] secretion in monocytic cells : enhanced activity of disease associated mutants and requirement for ASC . Positive_regulation IL1B NLRP3 15020601 1243439 The induction of activity by enforced oligomerization in THP-1 cells *resulted* in ASC binding and the secretion of [IL-1beta] , an effect that was abolished by the inhibition of ASC expression with small interfering RNAs . Positive_regulation IL1B NLRP3 16407888 1527483 and ASC are *essential* for caspase-1 activation and [IL-1beta] and IL-18 production in response to bacterial RNA and the imidazoquinoline compounds R837 and R848 . Positive_regulation IL1B NLRP3 16407890 1527496 Macrophages exposed to Gram positive Staphylococcus aureus or Listeria monocytogenes , however , *required* both ASC and to activate caspase-1 and secrete [IL-1beta] . Positive_regulation IL1B NLRP3 17008311 1647460 Finally , was *required* for [IL-1beta] production in response to poly ( I:C ) in vivo . Positive_regulation IL1B NLRP3 17403772 1760728 Using mice bearing selective gene deletions , we provide in vitro and in vivo data showing that MDP induced [IL-1beta] release *requires* Nod2 and as well as receptor interacting protein-2 (Rip2) , apoptosis associated speck-like protein containing a caspase activation and recruitment domain ( ASC ) , and caspase-1 . Positive_regulation IL1B NLRP3 18299853 1885855 Activated *mediates* [interleukin-1b (IL-1b)] generation from its inactive pro-form , resulting in the activation of further cells and an IL-8 mediated neutrophil influx into the joint . Positive_regulation IL1B NLRP3 18566365 1929599 In this study we show that , in human and mouse macrophages , alum induced secretion of [IL-1beta] , IL-18 , and IL-33 is *mediated* by the NLR ( nucleotide binding domain leucine-rich repeat containing ) protein and its adaptor ASC , but not by NLRC4 . Positive_regulation IL1B NLRP3 19258328 2062923 is *necessary* for [interleukin-1beta (IL-1beta)] release in response to hyaluronan , an endogenous trigger of inflammation in response to injury . Positive_regulation IL1B NLRP3 19587006 2111761 Using a pulmonary infection model that reflects human infection , we show that K. pneumonia induced mouse macrophage necrosis , HMGB1 , and [IL-1beta] release are *dependent* on and ASC . Positive_regulation IL1B NLRP3 19812205 2154388 In vivo experiments revealed that was *critical* for the production of [IL-1beta] but was not important for survival in a mouse model of S. pyogenes peritoneal infection . Positive_regulation IL1B NLRP3 20002790 2241031 activation with alum *caused* [interleukin-1beta] secretion and facilitated migration . Positive_regulation IL1B NLRP3 20008285 2191234 RNA interference and inhibitor experiments in human PBMCs as well as experiments in Nlrp3 and Rip2 knockout bone marrow derived macrophages demonstrated that the Listeria induced [IL-1beta] release was *dependent* on ASC , caspase-1 , and , whereas NOD2 , Rip2 , NLRP1 , NLRP6 , NLRP12 , NLRC4 , and AIM2 appeared to be dispensable . Positive_regulation IL1B NLRP3 20008285 2191235 In addition , an LLO dependent but cathepsin B-independent activation might *contribute* to some extent to the [IL-1beta] production in L. monocytogenes infected cells . Positive_regulation IL1B NLRP3 20193001 2216275 Having entered the cell , MSU further triggers inflammasome activation and *induces* the production of [IL-1 beta] , likely inducing a full spectrum of inflammation . Positive_regulation IL1B NLRP3 20393140 2262216 TLR2 was required for induction of pro-IL-1beta , whereas the was *required* for caspase-1 activation and pro-IL-1beta cleavage to produce mature [IL-1beta] . Positive_regulation IL1B NLRP3 20506209 2283824 M299V is an activating mutation in resulting in elevated spontaneous caspase 1 activity and [IL-1beta] *levels* . Positive_regulation IL1B NLRP3 20561679 2285197 The effect of surface modification of amorphous silica particles on inflammasome *mediated* [IL-1beta] production , ROS production and endosomal rupture . Positive_regulation IL1B NM 11114238 757772 Recombinant human interleukin-8 , but not human [interleukin-1beta] , *induces* bovine in an in vitro co-culture system . Positive_regulation IL1B NM 15615881 1357497 Dentin sialoprotein (DSP) and dentin phosphoprotein (DPP) , the major dentin proteins , have been shown to *induce* through release of [IL-1beta] , TNF-alpha , MIP-2 , and KC . Positive_regulation IL1B NOD1 12459189 1021711 *enhances* caspase-1 induced [IL-1beta] secretion , as well as lipopolysaccharide (LPS) induced IL-1beta secretion in transfected cells . Positive_regulation IL1B NOD1 12459189 1021712 Our data indicate that can *regulate* [IL-1beta] secretion , implying that Nod1 may play a role in inflammatory responses to bacterial LPS . Positive_regulation IL1B NOD1 12775719 1119761 In contrast to its effects on Nod1- and Cardiak dependent NF-kappa B activation , CARD6 did not interfere with caspase-1 dependent [interleukin-1 beta] secretion *induced* by Cardiak or . Positive_regulation IL1B NOD1 16021603 1441578 activation by low nanomolar concentrations of the specific muropeptide ligand M-TriDAP *induced* minimal human peripheral blood mononuclear cell TNF-alpha , [IL-1beta] or IL-10 secretion , but synergistically increased Toll-like receptor (TLR) induced responses . Positive_regulation IL1B NOD2 17403772 1760729 Using mice bearing selective gene deletions , we provide in vitro and in vivo data showing that MDP induced [IL-1beta] release *requires* and CIAS1/NALP3 as well as receptor interacting protein-2 (Rip2) , apoptosis associated speck-like protein containing a caspase activation and recruitment domain ( ASC ) , and caspase-1 . Positive_regulation IL1B NOD2 18157816 1847598 Although it is known that NOD2 mediates cytokine responses to muramyl dipeptide ( MDP ) , it is yet unclear whether NOD2 stimulation mediates only transcription of pro-IL-1beta mRNA , or whether is also *involved* in the activation of caspase-1 and release of active [IL-1beta] . Positive_regulation IL1B NOD2 18511561 1922435 Yet , the molecular mechanism by which can *stimulate* [IL-1beta] secretion , and its biological significance were heretofore unknown . Positive_regulation IL1B NOD2 18773284 2028351 Combined TLR2 and stimulation *induced* a four-fold higher secretion of TNFalpha and a 13-fold higher secretion of [IL-1 beta] in patients . Positive_regulation IL1B NOD2 19180500 2033125 Furthermore , functional studies demonstrate that caspase 1-mediated release of [IL-1beta] also *involves* . Positive_regulation IL1B NOS1 10365824 621115 We have previously reported that the inflammatory cytokine [interleukin-1beta (IL-1beta)] *induced* the expression of the inducible gene in primary cultured rat hepatocytes . Positive_regulation IL1B NOS1 10533051 562362 [Interleukin-1 beta] *activates* expression of cyclooxygenase-2 and inducible in primary hippocampal neuronal culture : platelet activating factor as a preferential mediator of cyclooxygenase-2 expression . Positive_regulation IL1B NOS1 11530235 853779 [Interleukin 1beta] *induced* both and cyclooxygenase 2 (COX-2) gene expression in dorsal root ganglion explant culture with increased NOS-2 and COX-2 activities , and corresponding increases in the production of nitric oxide and prostaglandin E ( 2 ) . Positive_regulation IL1B NOS1 12365794 995285 [Interleukin-1beta] in intra-islet macrophages may *induce* Fas and inducible expression in an autocrine and paracrine manner and mediate beta cell destruction or even death of some macrophages and T cells . Positive_regulation IL1B NOS1 12475221 1023534 In rat pancreatic islets and insulin producing cell lines , [IL-1beta] *induces* expression of inducible and NO production leading to impairment of glucose stimulated insulin release and decreased cell survival . Positive_regulation IL1B NOS1 1378360 190617 Balloon injury and [interleukin-1 beta] *induce* activity in rat carotid arteries . Positive_regulation IL1B NOS1 7505613 237675 [IL-1 beta] *induces* the coexpression of both and cyclooxygenase by islets of Langerhans : activation of cyclooxygenase by nitric oxide . Positive_regulation IL1B NOS1 7521071 269270 Cyclic nucleotide regulation of [interleukin-1 beta] *induced* expression in vascular smooth muscle cells . Positive_regulation IL1B NOS1 7686532 222264 These data demonstrate for the first time that [interleukin-1 beta] *induces* gene expression of inducible and its de novo protein synthesis in rat vascular smooth muscle cells , thereby leading to generation of nitric oxide via Ca2+/calmodulin independent and protein kinase C-independent mechanisms . Positive_regulation IL1B NOS1 7689226 225719 [IL-1 beta] resulting from cleavage of pIL-1 beta by SPE B *induced* activity in vascular smooth muscle cells and killed of the human melanoma A375 line . Positive_regulation IL1B NOS1 8737749 376965 Here we show that in cultured bovine chondrocytes and explants of human osteoarthritic cartilage both and cyclooxygenase activities were *induced* by the inflammatory mediators , lipopolysaccharide , and [interleukin-1 beta] or tumor necrosis factor-alpha . Positive_regulation IL1B NOS1 9341739 458749 We show that gene expression of IL-1 alpha , [IL-1 beta] , IL-6 , granulocyte-colony stimulating factor , and IL-10 was *induced* in both cell fractions , whereas increased mRNA levels of interferon-gamma and the inducible were exclusively detected in the patients ' nonadherent MNCs . Positive_regulation IL1B NOS2 10365824 621116 We have previously reported that the inflammatory cytokine [interleukin-1beta (IL-1beta)] *induced* the expression of the inducible gene in primary cultured rat hepatocytes . Positive_regulation IL1B NOS2 10533051 562363 [Interleukin-1 beta] *activates* expression of cyclooxygenase-2 and inducible in primary hippocampal neuronal culture : platelet activating factor as a preferential mediator of cyclooxygenase-2 expression . Positive_regulation IL1B NOS2 10577516 569530 When mouse peritoneal exudate cells ( PEC ) or RAW 264.7 cells were stimulated with lipopolysaccharide (LPS) , concomitant inhibition of *resulted* in an increase of [IL-1beta] and IL-1alpha protein secretion . Positive_regulation IL1B NOS2 10601882 574643 induction involves activation by phosphorylation of the MAP kinase p38 and can be *induced* in cultured astrocytes by [IL-1beta] or H2O2 . Positive_regulation IL1B NOS2 10702213 672498 Using rat hepatocytes in primary culture , gene transcription was *induced* by [IL-1beta] . Positive_regulation IL1B NOS2 11129085 759947 [Interleukin-1beta] ( 100 IU/mL ) , which *induces* in SMC from both control and atherosclerotic aortas causes accumulation of cyclic GMIP in the extracellular medium between 3 and 6 h for control SMC and between 3 and 24 h with atherosclerotic SMC . Positive_regulation IL1B NOS2 11216878 785908 2 ) LIF and IFN-gamma , but not [IL-1beta] , *induce* the mRNA expression in syncytiotrophoblast cells in vitro , suggesting possible similar regulatory mechanisms in vivo . Positive_regulation IL1B NOS2 11730360 884944 We found that both [IL-1beta] and TNF-alpha could independently activate cytosolic NF-kappaB , direct its translocation into the nucleus , and *induce* monomer synthesis . Positive_regulation IL1B NOS2 11872267 918549 The expression of was *induced* by [IL-1beta] and Abeta [ 25-35 ] and was partially inhibited by treatment with WSC . Positive_regulation IL1B NOS2 11880505 919464 In addition , we show that minocycline not only prevents MPTP induced activation of microglia but also the formation of mature [interleukin-1beta] and the *activation* of NADPH-oxidase and , three key microglial derived cytotoxic mediators . Positive_regulation IL1B NOS2 12062366 953183 These data demonstrate that [IL-1beta] , together with the priming effect of gamma-IFN , *induces* expression in skeletal muscle via activation of ERK1/ERK2 and NFkappaB . Positive_regulation IL1B NOS2 12120758 964997 The present study was to investigate the effect of a calcium antagonist amlodipine on nitrite , tumor necrosis factor-alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] formation and *induction* both in lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) treated rat aortic smooth muscle cells ( RASMC ) and in a rat model of endotoxemia . Positive_regulation IL1B NOS2 12365794 995286 [Interleukin-1beta] in intra-islet macrophages may *induce* Fas and inducible expression in an autocrine and paracrine manner and mediate beta cell destruction or even death of some macrophages and T cells . Positive_regulation IL1B NOS2 12384474 998793 In cultured adult rat CFbs , [IL-1beta] ( 5 ng/ml ) , but not interferon-gamma ( 10 ng/ml ) or tumor necrosis factor-alpha ( 10 ng/ml ) , *induced* expression and NO production that was associated with an increase in caspase-3 activity and apoptotic cell death . Positive_regulation IL1B NOS2 12475221 1023535 In rat pancreatic islets and insulin producing cell lines , [IL-1beta] *induces* expression of inducible and NO production leading to impairment of glucose stimulated insulin release and decreased cell survival . Positive_regulation IL1B NOS2 12757853 1090893 We conclude that colloidal-iron phagocytosed by liver Kupffer cells enhanced LPS induced NO production in vivo , *induction* in the liver , and release of IL-6 , [IL-1beta] , and TNF-alpha . Positive_regulation IL1B NOS2 1378360 190618 Balloon injury and [interleukin-1 beta] *induce* activity in rat carotid arteries . Positive_regulation IL1B NOS2 17015748 1629891 [IL-1beta] *induced* increased mRNA levels of MIP-2 , MCP-1 , RANTES , , and cyclooxygenase-2 (COX-2) in the IEC-18 cell line . Positive_regulation IL1B NOS2 17146391 1653978 These results suggest that the pro-inflammatory cytokine [IL-1beta] strongly *induces* expression and NO production in HEI-OC1 cells , and the induction appears to be achieved by increased iNOS transcription and activation of PI3 K signaling pathway . Positive_regulation IL1B NOS2 18077487 1847150 [IL-1beta] stimulation *induced* expression of reverted by 1 and 10 mmol/l GS . Positive_regulation IL1B NOS2 18957328 2014826 [Interleukin-1beta (IL-1beta)] and tumor necrosis factor-alpha (TNF-alpha) *induced* gene expression and NO production , although these actions were inhibited by L-NG-monomethylarginine ( L-NMMA ) and decreased alkaline phosphatase ( ALPase ) activity . Positive_regulation IL1B NOS2 7505613 237676 [IL-1 beta] *induces* the coexpression of both and cyclooxygenase by islets of Langerhans : activation of cyclooxygenase by nitric oxide . Positive_regulation IL1B NOS2 7517798 261753 [IL-1 beta] similarly *induced* mRNA expression in cultured adult rat cardiocytes in a time dependent manner . Positive_regulation IL1B NOS2 7517798 261774 These data demonstrate that [IL-1 beta] *induces* macrophage-type mRNA expression mainly by cardiac myocytes but also by nonmyocytes to a lesser extent , and subsequent de novo protein synthesis of iNOS leads to excessive local production of NO by cardiocytes . Positive_regulation IL1B NOS2 7519400 265581 Both the expression of iNOS and nitrite formation induced by IL-1 beta were prevented by the mRNA transcriptional inhibitor actinomycin D . [IL-1 beta] did not *induce* the expression of by FACS purified alpha-cells , the other major endocrine cell type of the islet . Positive_regulation IL1B NOS2 7520256 266271 However , following *activation* of in astrocytes by [interleukin-1 beta] plus interferon-gamma , NMDA but not kainate neurotoxicity was markedly potentiated . Positive_regulation IL1B NOS2 7521071 269271 Cyclic nucleotide regulation of [interleukin-1 beta] *induced* expression in vascular smooth muscle cells . Positive_regulation IL1B NOS2 7528993 284184 These data indicate that [IL-1 beta] *induces* gene expression and de novo synthesis of iNOS and subsequent NO generation in vascular endothelium and that TGF-beta and glucocorticoid block iNOS gene expression at the transcriptional level . Positive_regulation IL1B NOS2 7686532 222265 These data demonstrate for the first time that [interleukin-1 beta] *induces* gene expression of inducible and its de novo protein synthesis in rat vascular smooth muscle cells , thereby leading to generation of nitric oxide via Ca2+/calmodulin independent and protein kinase C-independent mechanisms . Positive_regulation IL1B NOS2 7689226 225720 [IL-1 beta] resulting from cleavage of pIL-1 beta by SPE B *induced* activity in vascular smooth muscle cells and killed of the human melanoma A375 line . Positive_regulation IL1B NOS2 8737749 376966 Here we show that in cultured bovine chondrocytes and explants of human osteoarthritic cartilage both and cyclooxygenase activities were *induced* by the inflammatory mediators , lipopolysaccharide , and [interleukin-1 beta] or tumor necrosis factor-alpha . Positive_regulation IL1B NOS2 8879343 390741 Thus , IL-1 beta controls gene expression at the transcriptional level , and an intermediate labile protein , whose synthesis is inhibited by cycloheximide , is *required* for [IL-1 beta] stimulated induction of iNOS mRNA transcription in WKY cells but not in SHR . Positive_regulation IL1B NOS2 8981400 403762 We conclude that during systemic inflammation vascular [IL-1 beta] , binding to vascular and perivascular IL-1RI receptors , may *induce* perivascular gene expression , leading to the production of NO and modulation of the effects of IL-1 beta in the brain . Positive_regulation IL1B NOS2 9341739 458750 We show that gene expression of IL-1 alpha , [IL-1 beta] , IL-6 , granulocyte-colony stimulating factor , and IL-10 was *induced* in both cell fractions , whereas increased mRNA levels of interferon-gamma and the inducible were exclusively detected in the patients ' nonadherent MNCs . Positive_regulation IL1B NOS2 9442805 475261 It has been shown that the is *induced* in islets of Langerhans by [interleukin-1 beta (IL-1 beta)] . Positive_regulation IL1B NOS2 9696008 524409 [IL-1beta] also *induced* NO production and gene expression . Positive_regulation IL1B NOS2 9751192 533516 The synergistic neurotoxic activity of hypoxia and [interleukin-1beta] was *dependent* on de novo expression of and on nitric oxide ( NO ) production in astrocytes . Positive_regulation IL1B NOS2 9753298 533904 CNTF potentiated IL-1beta mediated NO synthesis from RIN-5AH cells by 83 % , and [IL-1beta] *induced* islet mRNA expression fourfold . Positive_regulation IL1B NOS3 10365824 621117 We have previously reported that the inflammatory cytokine [interleukin-1beta (IL-1beta)] *induced* the expression of the inducible gene in primary cultured rat hepatocytes . Positive_regulation IL1B NOS3 10533051 562364 [Interleukin-1 beta] *activates* expression of cyclooxygenase-2 and inducible in primary hippocampal neuronal culture : platelet activating factor as a preferential mediator of cyclooxygenase-2 expression . Positive_regulation IL1B NOS3 12365794 995287 [Interleukin-1beta] in intra-islet macrophages may *induce* Fas and inducible expression in an autocrine and paracrine manner and mediate beta cell destruction or even death of some macrophages and T cells . Positive_regulation IL1B NOS3 12475221 1023536 In rat pancreatic islets and insulin producing cell lines , [IL-1beta] *induces* expression of inducible and NO production leading to impairment of glucose stimulated insulin release and decreased cell survival . Positive_regulation IL1B NOS3 1378360 190619 Balloon injury and [interleukin-1 beta] *induce* activity in rat carotid arteries . Positive_regulation IL1B NOS3 7505613 237677 [IL-1 beta] *induces* the coexpression of both and cyclooxygenase by islets of Langerhans : activation of cyclooxygenase by nitric oxide . Positive_regulation IL1B NOS3 7521071 269272 Cyclic nucleotide regulation of [interleukin-1 beta] *induced* expression in vascular smooth muscle cells . Positive_regulation IL1B NOS3 7686532 222266 These data demonstrate for the first time that [interleukin-1 beta] *induces* gene expression of inducible and its de novo protein synthesis in rat vascular smooth muscle cells , thereby leading to generation of nitric oxide via Ca2+/calmodulin independent and protein kinase C-independent mechanisms . Positive_regulation IL1B NOS3 7689226 225721 [IL-1 beta] resulting from cleavage of pIL-1 beta by SPE B *induced* activity in vascular smooth muscle cells and killed of the human melanoma A375 line . Positive_regulation IL1B NOS3 8737749 376967 Here we show that in cultured bovine chondrocytes and explants of human osteoarthritic cartilage both and cyclooxygenase activities were *induced* by the inflammatory mediators , lipopolysaccharide , and [interleukin-1 beta] or tumor necrosis factor-alpha . Positive_regulation IL1B NOS3 9341739 458751 We show that gene expression of IL-1 alpha , [IL-1 beta] , IL-6 , granulocyte-colony stimulating factor , and IL-10 was *induced* in both cell fractions , whereas increased mRNA levels of interferon-gamma and the inducible were exclusively detected in the patients ' nonadherent MNCs . Positive_regulation IL1B NOX1 10022882 590390 Reactive oxygen intermediate dependent NF-kappaB activation by [interleukin-1beta] *requires* 5-lipoxygenase or activity . Positive_regulation IL1B NOX1 11880505 919465 In addition , we show that minocycline not only prevents MPTP induced activation of microglia but also the formation of mature [interleukin-1beta] and the *activation* of and inducible nitric oxide synthase (iNOS) , three key microglial derived cytotoxic mediators . Positive_regulation IL1B NOX1 14967724 1212161 Cilostazol ( 1 to 100 micromol/L ) significantly suppressed not only *dependent* superoxide production but also TNF-alpha and [interleukin-1beta] release and restored viability . Positive_regulation IL1B NOX1 18523309 1922922 Nigericin , a K ( + ) /H ( + ) antiporter , also increases NADPH oxidase activity , leading to [IL-1beta] and caspase-1 processing that is *blocked* by a peroxynitrite scavenger or inhibition of . Positive_regulation IL1B NOX1 18929641 1994586 [Interleukin-1beta] , flagellin , interferon-gamma , and tumor necrosis factor alpha (TNF-alpha) similarly *induced* in a colon cancer cell line ( T84 ) , whereas only TNF-alpha fully induced NOXO1 and upregulated superoxide producing activity by ninefold . Positive_regulation IL1B NOX3 10022882 590391 Reactive oxygen intermediate dependent NF-kappaB activation by [interleukin-1beta] *requires* 5-lipoxygenase or activity . Positive_regulation IL1B NOX3 11880505 919466 In addition , we show that minocycline not only prevents MPTP induced activation of microglia but also the formation of mature [interleukin-1beta] and the *activation* of and inducible nitric oxide synthase (iNOS) , three key microglial derived cytotoxic mediators . Positive_regulation IL1B NOX3 14967724 1212162 Cilostazol ( 1 to 100 micromol/L ) significantly suppressed not only *dependent* superoxide production but also TNF-alpha and [interleukin-1beta] release and restored viability . Positive_regulation IL1B NOX3 18523309 1922923 Nigericin , a K ( + ) /H ( + ) antiporter , also increases NADPH oxidase activity , leading to [IL-1beta] and caspase-1 processing that is *blocked* by a peroxynitrite scavenger or inhibition of . Positive_regulation IL1B NOX4 10022882 590392 Reactive oxygen intermediate dependent NF-kappaB activation by [interleukin-1beta] *requires* 5-lipoxygenase or activity . Positive_regulation IL1B NOX4 11880505 919467 In addition , we show that minocycline not only prevents MPTP induced activation of microglia but also the formation of mature [interleukin-1beta] and the *activation* of and inducible nitric oxide synthase (iNOS) , three key microglial derived cytotoxic mediators . Positive_regulation IL1B NOX4 14967724 1212163 Cilostazol ( 1 to 100 micromol/L ) significantly suppressed not only *dependent* superoxide production but also TNF-alpha and [interleukin-1beta] release and restored viability . Positive_regulation IL1B NOX4 18523309 1922924 Nigericin , a K ( + ) /H ( + ) antiporter , also increases NADPH oxidase activity , leading to [IL-1beta] and caspase-1 processing that is *blocked* by a peroxynitrite scavenger or inhibition of . Positive_regulation IL1B NOX5 10022882 590388 Reactive oxygen intermediate dependent NF-kappaB activation by [interleukin-1beta] *requires* 5-lipoxygenase or activity . Positive_regulation IL1B NOX5 11880505 919463 In addition , we show that minocycline not only prevents MPTP induced activation of microglia but also the formation of mature [interleukin-1beta] and the *activation* of and inducible nitric oxide synthase (iNOS) , three key microglial derived cytotoxic mediators . Positive_regulation IL1B NOX5 14967724 1212160 Cilostazol ( 1 to 100 micromol/L ) significantly suppressed not only *dependent* superoxide production but also TNF-alpha and [interleukin-1beta] release and restored viability . Positive_regulation IL1B NOX5 18523309 1922921 Nigericin , a K ( + ) /H ( + ) antiporter , also increases NADPH oxidase activity , leading to [IL-1beta] and caspase-1 processing that is *blocked* by a peroxynitrite scavenger or inhibition of . Positive_regulation IL1B NOXO1 18929641 1994585 [Interleukin-1beta] , flagellin , interferon-gamma , and tumor necrosis factor alpha (TNF-alpha) similarly *induced* Nox1 in a colon cancer cell line ( T84 ) , whereas only TNF-alpha fully induced and upregulated superoxide producing activity by ninefold . Positive_regulation IL1B NPEPPS 10687142 669917 Significantly less encapsulated into liposomes ( Lipo-OK-PSA ) than OK-PSA alone ( 1/100 or less of OK-PSA alone ) was *required* to induce IFN-gamma , tumor necrosis factor-alpha (TNF-alpha) , TNF-beta , [interleukin-1 beta (IL-1 beta)] , natural killer , and lymphokine activated killer activities by human peripheral blood mononuclear cells and mouse spleen cells . Positive_regulation IL1B NPPA 10591026 572505 This study shows that [IL-1 beta] *induces* unique cardiac hypertrophy and the marked secretion of and BNP , and that NMC is indispensable when treated with IL-1 beta . Positive_regulation IL1B NPS 17301363 1184921 ( sp and CGRP ) *augment* [IL-1 Beta] production in hsv infected macrophages . Positive_regulation IL1B NPS 17301363 1184924 Each neuropeptide separately has upregulated [IL-1 beta] production by HSV- 1 infected macrophages with the greatest effect at the concentrations of 1 09M for both SP and CGRP , but no synergistic effect on IL-1 production has been observed in the *presence* of both at optimal concentrations . Positive_regulation IL1B NPY 11277982 798044 [Interleukin-1beta] *induces* expression of in primary astrocyte cultures in a cytokine-specific manner : induction in human but not rat astrocytes . Positive_regulation IL1B NPY4R 10657625 664083 OX8 ( CD8 alpha ) -induced TNF and [IL-1 beta] production by macrophages was *blocked* by inhibitors of protein tyrosine kinase ( s ) , , and genistein , but not by phosphatidylinositol-3 kinase inhibitor , wortmannin . Positive_regulation IL1B NPY6R 20302643 2238042 Increased secretion of IL-1beta was dependent upon p38 MAP kinase activity while Abeta1-40 secretion required Src family kinase activity since the specific p38 inhibitor , SB202190 , and the Src family kinase inhibitor , , *attenuated* [IL-1beta] and Abeta1-40 secretion , respectively . Positive_regulation IL1B NQO1 18981090 1983354 Silencing expression of alone , or in combination with heme oxygenase-1 (HO-1) silencing , markedly *increased* LPS induced TNF and [IL-1beta] expression . Positive_regulation IL1B NQO1 18981090 1983357 Additionally , overexpression of and/or HO-1 *inhibited* LPS induced TNF and [IL-1beta] expression . Positive_regulation IL1B NR0B1 15630159 1349388 In addition , *induced* increases in colonic mucosal [IL-1beta] , but not TNF-alpha , protein levels were significantly abrogated in 1 % AOB fed mice ( P < 0.05 ) . Positive_regulation IL1B NR0B1 16202978 1468539 First , we found that markedly *induced* [IL-1beta] production in both dose- and time dependent manners ( P < 0.05 and P < 0.01 , respectively ) in murine peritoneal macrophages ( pMphi ) , while that of tumor necrosis factor-alpha was insignificant . Positive_regulation IL1B NR0B1 17628610 1775142 We investigated *induced* [IL-1 beta] production and caspase-1 activities in murine peritoneal macrophages ( pM phi ) . Positive_regulation IL1B NR0B1 17628610 1775177 [IL-1 beta] release and caspase-1 activity *induced* by were significantly inhibited by a MAPK kinase 1/2 inhibitor , a p38 MAPK inhibitor , and NAC , however , not by JNK1/2 or a protein kinase C inhibitor . Positive_regulation IL1B NR0B1 17628610 1775204 Pre-treatment with anti-CXCL16 for 24 h , but not anti-scavenger receptor-A , anti-CD36 , or anti-CD68 antibodies , significantly suppressed *induced* [IL-1 beta] production . Positive_regulation IL1B NR0B1 17628610 1775205 Our results suggest that *triggers* the release of [IL-1 beta] protein from murine pM phi at a post-translational level through binding with CXCL16 , ROS generation , and resultant activation of both p38 MAPK and ERK1/2 pathways , and finally caspase-1 activation . Positive_regulation IL1B NR0B1 20442201 2307474 [IL-1beta] production in *response* to was studied in macrophages of wild-type , caspase-1 ( -/- ) , NLRP3 ( -/- ) , ASC ( -/- ) , cathepsin B ( -/- ) or cathepsin L ( -/- ) mice . Positive_regulation IL1B NRAS 14563479 1154849 Depletion of membrane bound cholesterol using methyl-beta-cyclodextrin , which also disrupts caveolar organization within the plasma membrane , abolished IL-1 beta induced NO release suggesting that [IL-1 beta] mediated *dependent* signaling in these cells involves the intermediacy of caveolae and their key constituents ( e.g. caveolin-1 ) in isolated beta cells . Positive_regulation IL1B NRAS 16543474 1574618 Interestingly , whereas IL-6 production required activation of both PI3K and Ras/Erk pathways , [IL-1beta] production was *dependent* only on activation , suggesting that SHIP may also regulate the Ras/Erk pathway in macrophages . Positive_regulation IL1B NRG1 20392965 2240428 Microglia express the NRG1 receptors erbB2 , 3 , and 4 , and signaling via the erbB2 receptor *stimulated* microglial proliferation , chemotaxis , and survival , as well as [interleukin-1beta] release in vitro . Positive_regulation IL1B NUP43 10775561 686669 These observations , combined with previous results , indicate that MAPK activation is *required* for [interleukin-1beta] induction of iNOS and that N-acetyl-L-cysteine may act as a reducing agent and facilitate interleukin-1beta induced iNOS expression through a reduction/oxidation related mechanism involving potentiation of cytokine activation of the p44/42 MAPK signaling pathway . Positive_regulation IL1B NUP43 11777983 899936 Furthermore , IL-17 , [IL-1beta] , and TNF-alpha *induced* a rapid activation of extracellular signal related kinase and p38 MAPKs , and specific MAPK inhibitors ( SB203580 , PD98059 , and U0216 ) significantly reduced IL-17- , IL-1beta- , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Positive_regulation IL1B NUP43 17395477 1728136 In the present study the quantitative *role* of and p38 in the production of TNF-alpha , [IL-1beta] and IL-12 by murine peritoneal macrophages , in vitro , on treatment with Concanavalin A ( ConA ) has been investigated . Positive_regulation IL1B NUP43 17395477 1728153 The expression of TNF-alpha , IL-1beta and IL-12 was down regulated in the presence of PD98059 and SB202190 in a dose dependent manner , suggesting the involvement of and p38 in ConA *induced* production of TNF-alpha , [IL-1beta] and IL-12 by macrophages . Positive_regulation IL1B ODC1 10623442 658038 [Interleukin-1beta] *induces* activity in insulin producing cells . Positive_regulation IL1B OMP 14622404 1169168 induced inflammatory cytokine responses of interleukin (IL)-8 , IL-6 and tumour necrosis factor (TNF)alpha in epithelial cells , and *induced* [IL-1beta] and TNFalpha production in mouse macrophages . Positive_regulation IL1B OPA1 16982859 1617262 In the present study , we show that osteopontin (OPN) , a proinflammatory involved in tissue repair , *induces* [IL-1beta] up-regulation in human monocytes . Positive_regulation IL1B OPRM1 12002806 939860 Recent work in our laboratory has demonstrated that the is *involved* in [interleukin-1beta (IL-1beta)-] and in lipopolysaccharide (LPS) induced fevers . Positive_regulation IL1B ORM1 8525785 331126 In conclusion , subcutaneous [interleukin-1 beta] ( probably by stimulation of interleukin-6 ) strongly *induces* fibrinogen and expression in rat liver , and suppresses immunohistochemically stainable albumin in a heterogenous way , mainly in the periportal zone . Positive_regulation IL1B ORM2 8525785 331127 In conclusion , subcutaneous [interleukin-1 beta] ( probably by stimulation of interleukin-6 ) strongly *induces* fibrinogen and expression in rat liver , and suppresses immunohistochemically stainable albumin in a heterogenous way , mainly in the periportal zone . Positive_regulation IL1B OXA1L 16450750 1521998 Both AGE modified beta2m and significantly *increased* TNF-alpha and [IL-1beta] secretion by human PMO in a dose dependent manner ( 50-200 microg/ml ) . Positive_regulation IL1B OXTR 16569740 1568497 [IL-1beta] *induces* an increase in OTR mRNA concentrations and ligand binding in myometrial cells , which is maximal at 4 h and decreased after 20 h . IL-1beta activates the transcription factors AP-1 C/EBPbeta , and NF-kappaB . Positive_regulation IL1B P2RX6 9053458 417243 Our data suggest that LPS dependent [IL-1 beta] release *involves* activation of this as it is inhibited by the selective P2Z/P2X7 blocker oxidized ATP and modulated by ATP hydrolyzing enzymes such as apyrase or hexokinase . Positive_regulation IL1B P2RX7 12626557 1066753 Using primary cultured murine peritoneal macrophages , we demonstrate that receptor activation *causes* release of [IL-1 beta] and IL-1 alpha via a common pathway , dependent upon the release of Ca ( 2+ ) from endoplasmic reticulum stores and caspase-1 activity . Positive_regulation IL1B P2RX7 12759456 1091273 To investigate the relationship between the *dependent* changes in plasma membrane organization and the release of [IL-1 beta] , we generated time-lapse movies of ATP stimulated BAC1 murine macrophages in conjunction with biochemical analyses of IL-1 beta release . Positive_regulation IL1B P2RX7 12759456 1091276 Thus , activation signals distinct , novel membrane blebbing events ( dependent on RhoA activation and Rho-effector kinase activity ) and simultaneously *initiates* release of [IL-1 beta] . Positive_regulation IL1B P2RX7 12796490 1120089 Maturation and release of [interleukin-1beta] by lipopolysaccharide primed mouse Schwann cells *require* the stimulation of receptors . Positive_regulation IL1B P2RX7 12796490 1120104 Taken together , these results show that receptor stimulation and associated BK channels , through the activation of ICE , *leads* to the maturation and the release of [IL-1beta] by immune challenged Schwann cells . Positive_regulation IL1B P2RX7 15385641 1300145 We therefore tested whether MTX treatment of lipopolysaccharide primed murine macrophages would mimic the ability of activated to *induce* secretion of the proinflammatory cytokine [interleukin-1beta (IL-1beta)] . Positive_regulation IL1B P2RX7 15883745 1406650 Activation of receptors on RPC *resulted* in [IL-1 beta] secretion , which was inhibited by PPADS . Positive_regulation IL1B P2RX7 16301672 1485265 Inhibitory effects of chloride on the *activation* of caspase-1 , [IL-1beta] secretion , and cytolysis by the receptor . Positive_regulation IL1B P2RX7 16837047 1666088 We used this information to further investigate the mechanisms of [IL-1beta] release *induced* by mammalian and fish receptors . Positive_regulation IL1B P2RX7 16837047 1666089 However , activation of rat receptors ectopically expressed in HEK293 together with human ICE *led* to the specific secretion of unprocessed seabream [IL-1beta] . Positive_regulation IL1B P2RX7 16837047 1666090 In contrast , neither seabream nor zebrafish receptors *induced* the secretion of mammalian or fish [IL-1beta] when expressed in HEK293 , while a chimeric receptor harboring the ATP binding domain of seabream P2X(7) and the intracellular region of its rat counterpart did so . Positive_regulation IL1B P2RX7 16837047 1666093 These findings indicate that receptor mediated activation of ICE and release of [IL-1beta] *result* from different downstream signaling pathways and suggest that although the mechanisms involved in IL-1beta secretion are conserved throughout evolution , distinct inflammatory signals have been selected for the secretion of this cytokine in different vertebrates . Positive_regulation IL1B P2RX7 17036048 1634547 Here , we identify pannexin-1 , a recently described mammalian protein that functions as a hemichannel when ectopically expressed , as this dye-uptake pathway and show that signalling through pannexin-1 is required for processing of caspase-1 and release of mature [IL-1beta] *induced* by receptor activation . Positive_regulation IL1B P2RX7 17351655 1727217 Activation of *resulted* in low-level release of bioactive [IL-1beta] and simultaneous release of IL-1Ra . Positive_regulation IL1B P2RX7 17491021 1761575 However , the *roles* of receptor and intracellular K ( + ) in [IL-1beta] secretion induced by bacterial infection remain unknown . Positive_regulation IL1B P2RX7 17641058 1771325 We compared the contribution of these mechanisms to *stimulated* [IL-1 beta] secretion in primary bone marrow derived macrophages isolated from wild-type , P2X7R knockout , or apoptosis associated speck-like protein containing a C-terminal CARD knockout mice . Positive_regulation IL1B P2RX7 17785807 1790739 However , secretion of [IL-1beta] , which *requires* ligation during infection by other pathogens , was decreased mildly and only at short times of infection . Positive_regulation IL1B P2RX7 17905568 1843822 In vitro and in vivo evidence for a *role* of the receptor in the release of [IL-1 beta] in the murine brain . Positive_regulation IL1B P2RX7 18089587 1868634 [Interleukin-1 beta] secretion from cord blood mononuclear cells in vitro *involves* receptor activation . Positive_regulation IL1B P2RX7 18089587 1868636 The authors examine protein and molecular expression of the receptor and its ability to *stimulate* [interleukin-1 beta] release in cord blood mononuclear cells ( CBMCs ) from placentae of term nonlaboring and laboring women . Positive_regulation IL1B P2RX7 18490713 1916914 Activation of purinergic receptors ( P2X(7)R ) by extracellular ATP is a key physiological *inducer* of rapid [IL-1beta] release from LPS primed macrophage . Positive_regulation IL1B P2RX7 18490713 1916917 We used peritoneal macrophage from P2X(7)R ( -/- ) mice and found that release of IL-1alpha , IL-18 , as well as [IL-1beta] , by ATP *resulted* exclusively from activation of , release of all these IL-1 cytokines involved pannexin-1 (panx1) , and that there was both a panx1 dependent and -independent component to IL-1beta release . Positive_regulation IL1B P2RX7 18523246 1922690 In this study , we determined whether the lysophospholipids , i.e. , LPC and sphingosylphosphorylcholine (SPC) , modulate the ATP induced release and processing of [IL-1beta] *mediated* by in mouse MG6 microglial cells . Positive_regulation IL1B P2RX7 18523309 1922925 These data demonstrate that signaling via NADPH oxidase activity is fundamental for the processing of mature [IL-1beta] *induced* by stimulation . Positive_regulation IL1B P2RX7 18996151 2022161 Activation of receptors *results* in the rapid release of [interleukin-1 beta (IL-1 beta)] . Positive_regulation IL1B P2RX7 19212823 2079418 Inhibition of pannexin-1 blocks *mediated* [IL-1beta] release from macrophage as well as release mediated by other stimuli which couple to activation of capase-1 and additionally inhibits the release of interleukin-1alpha , a member of the IL-1 family whose processing does not require caspase-1 activation . Positive_regulation IL1B P2RX7 19464323 2115559 These data demonstrate that selective blockade of P2X7 receptors in vivo produces significant antinociception in animal models of inflammatory pain and suggest that the antihyperalgesic effects of receptor blockade in an inflammatory pain model in mice are *mediated* by blocking the release of [IL-1beta] . Positive_regulation IL1B P2RX7 19547756 2099370 We have previously shown that [IL-1beta] synthesis in the hippocampus is *dependent* on receptor ( P2X(7)R ) , which is an ionotropic receptor of ATP . Positive_regulation IL1B P2RX7 20071520 2194134 *dependent* release of [interleukin-1beta] and nociception in the spinal cord following lipopolysaccharide . Positive_regulation IL1B P2RX7 20071520 2194137 We observed that lipopolysaccharide (LPS) induced release of [IL-1beta] was *prevented* by pharmacological inhibition of the receptor with A-438079 , and was absent in spinal cord slices taken from P2X7 knock-out mice . Positive_regulation IL1B P2RX7 20071520 2194138 Application of ATP did not evoke release of [IL-1beta] from the dorsal horn unless preceded by an LPS priming stimulus , and this release was *dependent* on receptor activation . Positive_regulation IL1B P2RX7 20185692 2272449 and 3 ) to test whether stimulation in T84 monolayers can *induce* caspase-1 activation and [IL-1beta] release by IEC . Positive_regulation IL1B PAF1 10447739 577421 We conclude that CRH and can *induce* the expression of [IL-1beta] , but this is not obligatory for increased PGE2 release , and the effect of these stimuli on COX-2 expression is a direct , IL-1beta independent effect . Positive_regulation IL1B PAF1 16025141 1453422 TNF-alpha was necessary for the local *induced* [IL-1beta] production . Positive_regulation IL1B PAF1 16439466 1554560 H ( 2 ) O ( 2 ) causes formation of [IL-1beta] that may *induce* production of in the muscle , possibly closing a self sustaining cycle of production of inflammatory mediators . Positive_regulation IL1B PAF1 16829183 1591461 Both TNF-alpha and [IL-1beta] induced HUVEC platelet activating factor (PAF) production and was *required* for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine ) . Positive_regulation IL1B PAF1 1710753 158265 , alone and in combination with endotoxin , *caused* an increase in mRNA levels for [IL-1 beta] . Positive_regulation IL1B PAF1 8080039 270829 [Interleukin-1 beta] and tumor necrosis factor-alpha *induce* production by endothelium , and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist . Positive_regulation IL1B PAH 18830893 1971134 *induced* significant secretion of [IL-1beta] , IL-8 , and IL-12 after 24 or 48 hr of treatment , an effect reinforced by LPS stimulation ; Positive_regulation IL1B PAK1 15561713 1367957 NF-kappaB- and C/EBPbeta-driven [interleukin-1beta] gene expression and mediated caspase-1 *activation* play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide stimulated macrophages . Positive_regulation IL1B PAM 20445007 2268379 In contrast , delayed DEX addition significantly suppressed *induced* [IL-1beta] , IL-6 , or IL-8 and also suppressed LPS induced IL-1beta and IL-8 . Positive_regulation IL1B PANX1 17121814 1686336 couples to maitotoxin- and nigericin *induced* [interleukin-1beta] release through a dye uptake independent pathway . Positive_regulation IL1B PANX1 17121814 1686340 Thus , although is *required* for [IL-1beta] release in response to maitotoxin , nigericin , and ATP , a mechanism distinct from pannexin-1 hemichannel activation must underlie the former two processes . Positive_regulation IL1B PARP1 11403206 825001 inhibition with GPI 6150 *blocked* the [IL-1beta] mediated stimulation of both ICAM-1 and E-selectin expression , and blocked TNF-alpha stimulation of ICAM-1 expression at 24 h . Positive_regulation IL1B PARP1 16356201 1645612 Interestingly , quantitative real-time PCR and ELISA analysis revealed that the absence of *down-regulated* [IL-1beta] and monocyte chemotactic protein 1 expression in arthritic joints whereas tumor necrosis factor-alpha transcription was not impaired . Positive_regulation IL1B PARP10 11403206 824996 inhibition with GPI 6150 *blocked* the [IL-1beta] mediated stimulation of both ICAM-1 and E-selectin expression , and blocked TNF-alpha stimulation of ICAM-1 expression at 24 h . Positive_regulation IL1B PARP11 11403206 824993 inhibition with GPI 6150 *blocked* the [IL-1beta] mediated stimulation of both ICAM-1 and E-selectin expression , and blocked TNF-alpha stimulation of ICAM-1 expression at 24 h . Positive_regulation IL1B PARP12 11403206 824994 inhibition with GPI 6150 *blocked* the [IL-1beta] mediated stimulation of both ICAM-1 and E-selectin expression , and blocked TNF-alpha stimulation of ICAM-1 expression at 24 h . Positive_regulation IL1B PARP14 11403206 825005 inhibition with GPI 6150 *blocked* the [IL-1beta] mediated stimulation of both ICAM-1 and E-selectin expression , and blocked TNF-alpha stimulation of ICAM-1 expression at 24 h . Positive_regulation IL1B PARP15 11403206 824999 inhibition with GPI 6150 *blocked* the [IL-1beta] mediated stimulation of both ICAM-1 and E-selectin expression , and blocked TNF-alpha stimulation of ICAM-1 expression at 24 h . Positive_regulation IL1B PARP16 11403206 824997 inhibition with GPI 6150 *blocked* the [IL-1beta] mediated stimulation of both ICAM-1 and E-selectin expression , and blocked TNF-alpha stimulation of ICAM-1 expression at 24 h . Positive_regulation IL1B PARP2 11403206 825003 inhibition with GPI 6150 *blocked* the [IL-1beta] mediated stimulation of both ICAM-1 and E-selectin expression , and blocked TNF-alpha stimulation of ICAM-1 expression at 24 h . Positive_regulation IL1B PARP3 11403206 825004 inhibition with GPI 6150 *blocked* the [IL-1beta] mediated stimulation of both ICAM-1 and E-selectin expression , and blocked TNF-alpha stimulation of ICAM-1 expression at 24 h . Positive_regulation IL1B PARP4 11403206 825002 inhibition with GPI 6150 *blocked* the [IL-1beta] mediated stimulation of both ICAM-1 and E-selectin expression , and blocked TNF-alpha stimulation of ICAM-1 expression at 24 h . Positive_regulation IL1B PARP6 11403206 825000 inhibition with GPI 6150 *blocked* the [IL-1beta] mediated stimulation of both ICAM-1 and E-selectin expression , and blocked TNF-alpha stimulation of ICAM-1 expression at 24 h . Positive_regulation IL1B PARP8 11403206 824998 inhibition with GPI 6150 *blocked* the [IL-1beta] mediated stimulation of both ICAM-1 and E-selectin expression , and blocked TNF-alpha stimulation of ICAM-1 expression at 24 h . Positive_regulation IL1B PARP9 11403206 824995 inhibition with GPI 6150 *blocked* the [IL-1beta] mediated stimulation of both ICAM-1 and E-selectin expression , and blocked TNF-alpha stimulation of ICAM-1 expression at 24 h . Positive_regulation IL1B PDGFB 9284956 451876 Expression of KGF transcript was down-regulated by EGF , TGF-alpha , and , was markedly *up-regulated* by [IL-1 beta] , and was more pronounced in limbal than in corneal fibroblasts . Positive_regulation IL1B PDGFRB 16477012 1554858 [PDGF-BB/IL-1beta] *induced* a sustained phosphorylation of and its association with IL-1 receptor ( IL-1R1 ) . Positive_regulation IL1B PGA3 19737897 2186519 The extracellular release of [IL-1beta] in *response* to was ICE dependent , since the administration of an ICE inhibitor prior to PGA treatment blocked induction of IL-1beta . Positive_regulation IL1B PGA4 19737897 2186520 The extracellular release of [IL-1beta] in *response* to was ICE dependent , since the administration of an ICE inhibitor prior to PGA treatment blocked induction of IL-1beta . Positive_regulation IL1B PGA5 19737897 2186521 The extracellular release of [IL-1beta] in *response* to was ICE dependent , since the administration of an ICE inhibitor prior to PGA treatment blocked induction of IL-1beta . Positive_regulation IL1B PGD 16423868 1533933 In Sertoli epithelial cells , the [IL-1beta] *induces* prostaglandins ( PG ) PGE ( 2 ) , PGF ( 2alpha ) and PGI ( 2 ) ( 7- , 11- , and 2-fold , respectively ) , but not ( 2 ) , production . Positive_regulation IL1B PGF 14611637 1162785 In rats , ( 2alpha ) and interleukin 1beta (IL-1beta) are *involved* in structural luteolysis , PGF ( 2alpha ) by increasing ovarian lipid peroxidation , and [IL-1beta] by reducing progesterone and increasing PGF ( 2alpha ) concentrations . Positive_regulation IL1B PHKA2 18453587 1909119 Using pharmacological inhibitors and small interfering RNA gene knockdown , we demonstrated that concomitant activation of Lyn , , and class IA PI3K are *required* for gp120 induced [IL-1beta] production . Positive_regulation IL1B PI3 12616480 1065633 The induction of [IL-1beta] , but not of MIP-2 or TNF-alpha , was *blocked* by the inhibitors LY294002 and wortmannin . Positive_regulation IL1B PI3 15266826 1276033 Among the inhibitors of intracellular signaling transduction pathways , mitogen activated protein kinases (MAPK) inhibitor PD98059 ( 40 micromol/L ) and p38 MAPK inhibitor SB203580 ( 5 micromol/L ) completely blocked the stimulatory effect of IL-1beta , and inhibitor LY294002 ( 10 micromol/L ) partly *blocked* the induction of [IL-1beta] . Positive_regulation IL1B PI3 17035941 1649238 SB 203580 , a p38 mitogen activated protein kinase inhibitor , weakly inhibited the induction of VEGF by IL-1beta in a concentration dependent manner , whereas LY 294002 , a inhibitor , and rapamycin , a mammalian target of rapamycin (mTOR) inhibitor , strongly *inhibited* both [IL-1beta-] and tumor necrosis factor-alpha induced VEGF formation in a concentration dependent manner . Positive_regulation IL1B PI3 18471882 1921597 We previously demonstrated that *regulate* differential production of [IL-1beta] and its specific inhibitor secreted IL-1 receptor antagonist ( sIL-1Ra ) by human monocytes . Positive_regulation IL1B PI3 8858138 388413 [Interleukin-1 beta] *activates* in renal mesangial cells . Positive_regulation IL1B PIK3C3 10657625 664081 OX8 ( CD8 alpha ) -induced TNF and [IL-1 beta] production by macrophages was *blocked* by inhibitors of protein tyrosine kinase ( s ) , PP1 , and genistein , but not by inhibitor , wortmannin . Positive_regulation IL1B PIK3C3 15271652 1333118 We hypothesized that EGF stimulates the expression of the inducible NO synthase (iNOS) gene in the graft after SBT , followed by increased production of NO , resulting in the decrease of BT. Intestinal epithelial cells ( IEC ) -6 were treated with EGF and/or [IL-1beta] in the *presence* and absence of ( PI3-kinase ) and EGF receptor kinase inhibitors ( LY-294002 and tyrphostin A25 ) . Positive_regulation IL1B PIK3C3 16359550 1494029 Selective inhibitors of extracellular signal regulated kinase , c-Jun N-terminal kinase and *reduced* the activity of [IL-1beta] on MMP-12 , indicating a role for these kinases in IL-1beta induced induction and release of MMP-12 . Positive_regulation IL1B PIK3C3 18205733 1895391 inhibitors added during the tolerance-induction period markedly *attenuated* the increase in [interleukin-1 beta] secretion but had no effect on tumor necrosis factor-alpha . Positive_regulation IL1B PIK3CA 10593868 572833 We also show that the signaling pathways resulting in the induction of IL-1beta synthesis by rgp350 required protein kinase C and phosphatidylinositol 3,4,5 triphosphate kinase activities and occurred via activation of the NF-kappaB family of transcription factors.-D'Addario , M. , Ahmad , A. , Xu , J. W. , Menezes , J. Epstein-Barr virus envelope glycoprotein gp350 induces NF-kappaB activation and [IL-1beta] synthesis in human monocytes-macrophages *involving* PKC and . Positive_regulation IL1B PIK3CA 11582579 865537 The protein kinase C ( PKC ) inhibitor H7 and the ( PI3-kinase ) inhibitor wortmannin *inhibited* induction of [IL-1beta] and IL-6 expression , which suggests that radiation induced IL-1beta and IL-6 expression is achieved by PKC- and PI3-kinase mediated signaling . Positive_regulation IL1B PIK3CA 14688354 1190720 Inhibition of *resulted* in increased serum levels of [IL1-beta] , IL-2 , IL-6 , IL-10 , IL-12 , and TNF-alpha in septic mice . Positive_regulation IL1B PIK3CA 15665520 1365601 The study shows that but not MAPKK-1 inhibition *resulted* in the loss of hypoxic and [IL-1beta] induced HIF-1alpha accumulation , whereas VEGF synthesis was reduced by either intervention . Positive_regulation IL1B PIK3CA 17132626 1686685 In parallel , ATP mediated ROS dependent is *required* for activation of caspase-1 and secretion of [IL-1beta] and IL-18 . Positive_regulation IL1B PIK3CA 17442978 1729728 In addition , inhibition *resulted* in strongly elevated TLR-4 mediated generation of [IL-1beta] and IL-8 in neutrophils when these cells were co-stimulated with C5a . Positive_regulation IL1B PIK3CA 18239058 1877016 An inhibitor of ( LY294002 ) significantly *suppressed* [IL-1beta-] , IFN-gamma- , and TNF-alpha induced IL-32alpha mRNA expression , although MAPK inhibitors had no effect . Positive_regulation IL1B PIK3CA 18453587 1909120 Using pharmacological inhibitors and small interfering RNA gene knockdown , we demonstrated that concomitant activation of Lyn , Pyk2 , and class IA are *required* for gp120 induced [IL-1beta] production . Positive_regulation IL1B PIK3CA 19494504 2091692 Eotaxin induced production of [IL-1beta] , IL-6 , and MIP-1beta was significantly *reduced* by the MEK inhibitor PD98059 , p38 MAPK inhibitor SB203580 , or inhibitor LY294002 . Positive_regulation IL1B PIK3R1 10593868 572834 We also show that the signaling pathways resulting in the induction of IL-1beta synthesis by rgp350 required protein kinase C and phosphatidylinositol 3,4,5 triphosphate kinase activities and occurred via activation of the NF-kappaB family of transcription factors.-D'Addario , M. , Ahmad , A. , Xu , J. W. , Menezes , J. Epstein-Barr virus envelope glycoprotein gp350 induces NF-kappaB activation and [IL-1beta] synthesis in human monocytes-macrophages *involving* PKC and . Positive_regulation IL1B PIK3R1 11582579 865538 The protein kinase C ( PKC ) inhibitor H7 and the ( PI3-kinase ) inhibitor wortmannin *inhibited* induction of [IL-1beta] and IL-6 expression , which suggests that radiation induced IL-1beta and IL-6 expression is achieved by PKC- and PI3-kinase mediated signaling . Positive_regulation IL1B PIK3R1 14688354 1190721 Inhibition of *resulted* in increased serum levels of [IL1-beta] , IL-2 , IL-6 , IL-10 , IL-12 , and TNF-alpha in septic mice . Positive_regulation IL1B PIK3R1 15665520 1365602 The study shows that but not MAPKK-1 inhibition *resulted* in the loss of hypoxic and [IL-1beta] induced HIF-1alpha accumulation , whereas VEGF synthesis was reduced by either intervention . Positive_regulation IL1B PIK3R1 17132626 1686686 In parallel , ATP mediated ROS dependent is *required* for activation of caspase-1 and secretion of [IL-1beta] and IL-18 . Positive_regulation IL1B PIK3R1 17442978 1729729 In addition , inhibition *resulted* in strongly elevated TLR-4 mediated generation of [IL-1beta] and IL-8 in neutrophils when these cells were co-stimulated with C5a . Positive_regulation IL1B PIK3R1 18239058 1877017 An inhibitor of ( LY294002 ) significantly *suppressed* [IL-1beta-] , IFN-gamma- , and TNF-alpha induced IL-32alpha mRNA expression , although MAPK inhibitors had no effect . Positive_regulation IL1B PIK3R1 18453587 1909121 Using pharmacological inhibitors and small interfering RNA gene knockdown , we demonstrated that concomitant activation of Lyn , Pyk2 , and class IA are *required* for gp120 induced [IL-1beta] production . Positive_regulation IL1B PIK3R1 19494504 2091693 Eotaxin induced production of [IL-1beta] , IL-6 , and MIP-1beta was significantly *reduced* by the MEK inhibitor PD98059 , p38 MAPK inhibitor SB203580 , or inhibitor LY294002 . Positive_regulation IL1B PIK3R4 10657625 664082 OX8 ( CD8 alpha ) -induced TNF and [IL-1 beta] production by macrophages was *blocked* by inhibitors of protein tyrosine kinase ( s ) , PP1 , and genistein , but not by inhibitor , wortmannin . Positive_regulation IL1B PIK3R4 15271652 1333119 We hypothesized that EGF stimulates the expression of the inducible NO synthase (iNOS) gene in the graft after SBT , followed by increased production of NO , resulting in the decrease of BT. Intestinal epithelial cells ( IEC ) -6 were treated with EGF and/or [IL-1beta] in the *presence* and absence of ( PI3-kinase ) and EGF receptor kinase inhibitors ( LY-294002 and tyrphostin A25 ) . Positive_regulation IL1B PIK3R4 16359550 1494030 Selective inhibitors of extracellular signal regulated kinase , c-Jun N-terminal kinase and *reduced* the activity of [IL-1beta] on MMP-12 , indicating a role for these kinases in IL-1beta induced induction and release of MMP-12 . Positive_regulation IL1B PIK3R4 18205733 1895392 inhibitors added during the tolerance-induction period markedly *attenuated* the increase in [interleukin-1 beta] secretion but had no effect on tumor necrosis factor-alpha . Positive_regulation IL1B PLA2G1B 10675243 667695 The 85 kDa was *induced* by [interleukin-1beta] , whereas there was no apparent change in secretory phospholipase A2 enzyme concentrations . Positive_regulation IL1B PLA2G1B 1577722 187475 [Interleukin-1 beta] and forskolin *induce* prostaglandin E2 release as well as 14-kDa group II gene expression and secretion of the enzyme from rat glomerular mesangial cells . Positive_regulation IL1B PLA2G1B 16741924 1612416 As indicated by pharmacological studies , the full PGE2 dependent potentiation of [IL-1beta] *induced* secretion is associated with a change of regulation exerted by the subtypes 3 G ( i ) -coupled PGE2 receptors toward adenylyl cyclase ( s ) activated by the subtype 4 G ( s ) -linked PGE2 receptor . Positive_regulation IL1B PLA2G1B 19675207 2150733 [IL-1beta] release at a low TLO dose *requires* potassium efflux , calcium influx , and the activities of calcium independent , caspase-1 , and cathepsin B . Positive_regulation IL1B PLA2G1B 2129785 150664 Recombinant [Interleukin-1 beta] ( rIL-1 beta ) induced dose dependent synthesis of PGE2 and *activation* of both cell associated and soluble in cultured mouse peritoneal macrophages . Positive_regulation IL1B PLA2G1B 8224206 234765 [Interleukin-1 beta] *induces* gene expression and secretion of the secretory ( sPLA2 ) and prostaglandin E2 ( PGE2 ) release from rat mesangial cells . Positive_regulation IL1B PLA2G1B 8273584 239503 [Interleukin-1 beta] *induces* cytosolic in parallel with prostaglandin E2 in rheumatoid synovial fibroblasts . Positive_regulation IL1B PLA2G1B 8832976 385870 The *role* of the cytosolic 85 kDa in [IL-1beta] induced human rheumatoid synovial fibroblast PGE2 formation was directly evaluated using an antisense phosphorothioate oligonucleotide to the initiation site of the 85 kDa PLA2 mRNA . Positive_regulation IL1B PLA2G1B 9109430 424828 The present study showed that [IL-1beta] *induced* the sustained synthesis of prostaglandin E2 and a parallel increase in type II sPLA2 gene expression ( assessed by enzymatic activity and Northern blot analysis ) , but no increase in cytosolic PLA2 gene expression ( assessed by Northern and Western blot analysis ) or cytosolic activity in rabbit articular chondrocytes . Positive_regulation IL1B PLA2G1B 9510087 491809 Antimalarial drugs inhibit activation and *induction* of [interleukin 1beta] and tumor necrosis factor alpha in macrophages : implications for their mode of action in rheumatoid arthritis . Positive_regulation IL1B PLA2G1B 9555020 499668 Platelet derived growth factor (PDGF)-BB potently inhibits secretion of [IL-1beta-] and forskolin *induced* group II activity . Positive_regulation IL1B PLA2G4A 10225377 610244 We have shown previously that trifluoromethylketone inhibitors of *suppressed* [interleukin-1beta] protein and steady-state mRNA levels in human lipopolysaccharide stimulated peripheral blood mononuclear leukocytes . Positive_regulation IL1B PLA2G4A 11863390 917485 We have shown that [IL-1 beta] *induces* the in vitro expression of genes believed to play important role in ovulation ( IL-1 beta itself , its receptors , IL-1 beta receptor antagonist , glucose transporters 1 and 3 , secretory and , prostaglandin endoperoxide synthase 1 and 2 ) . Positive_regulation IL1B PLA2G4A 15950779 1421564 We report that [IL-1beta] *induced* and COX-2 mRNA and protein expression and subsequent prostaglandin E2 ( PGE2 ) release in a time dependent manner in H4 neuroglioma cells . Positive_regulation IL1B PLA2G4A 18457971 1909369 p38 MAPK inhibitor SB203580 suppressed [interleukin-1beta (IL-1beta)] and interleukin-6 (IL-6) release , as well as the *activation* of . Positive_regulation IL1B PLA2G4A 7480804 326817 [Interleukin-1 beta] *induces* the synthesis and activity of and the release of prostaglandin E2 in human amnion derived WISH cells . Positive_regulation IL1B PLA2G4A 7480804 326821 The parallel increase in total cellular cPLA2 activity and cPLA2 protein level indicates that [IL-1 beta] may *induce* the synthesis of . Positive_regulation IL1B PLA2G4A 9196277 438473 In vitro , inhibitors of diminished surface expression of Mac-1 ( CD11b/CD18 ) beta2-integrin on calcium ionophore stimulated human blood granulocytes and *suppressed* synthesis of [interleukin-1beta] in lipopolysaccharide stimulated human blood monocytes and U937 cells by reducing mRNA levels . Positive_regulation IL1B PLAA 9227468 443231 [IL-1 beta] *induces* synthesis of in rabbit distal colon . Positive_regulation IL1B PLAU 11519039 851878 We previously reported that both [IL-1beta] and LPS *induce* in RC-K8 human lymphoma cells . Positive_regulation IL1B PLAU 8772229 344233 These results suggest that both IL-1 alpha and [IL-1 beta] cause a rapid activation of uPA gene transcription in which de novo protein synthesis is not required and that LPS *induces* gene expression independently of the IL-1 pathway . Positive_regulation IL1B PLG 14651966 1173618 *induced* [IL-1beta] and TNF-alpha production in microglia is regulated by reactive oxygen species . Positive_regulation IL1B PLG 14651966 1173619 Serine protease inhibitors suppressed both plasminogen- and *induced* [IL-1beta] and TNF-alpha expression , indicating the importance of serine protease activity in plasminogen/plasmin activation of microglia . Positive_regulation IL1B PLSCR1 17590392 1792431 These results indicate that maximal stimulation of by LPS in liver *required* TNFalpha and/or [IL-1beta] , whereas the stimulation of PLSCR1 in adipose tissue is not dependent on TNFalpha and/or IL-1beta . Positive_regulation IL1B PMPCB 23898995 2822155 The results showed that VacA overexpression *induced* the production of tumor necrosis factor alpha ( TNF-a ) , [interleukin-1 beta] ( IL-1ß ) , nitric oxide , and reactive oxygen species in THP-1 cells in a time dependent manner . Positive_regulation IL1B PMPS 11583705 865781 *induced* interleukin-8 (IL-8) , [interleukin-1 beta (IL-1 beta)] , and tumor necrosis factor alpha (TNF alpha) production by THP-1 . Positive_regulation IL1B PMPS 11583705 865786 also *induced* IL-8 , [IL-1 beta] , and interleukin-6 (IL-6) production by ECs . Positive_regulation IL1B PMS1 15103492 1258360 Therefore , [IL-1beta] *induces* both a pro- and an anti-inflammatory response in pediatric PMs , whereas adult produce only pro-inflammatory cytokines in response to IL-1beta . Positive_regulation IL1B PMS2 15103492 1258361 Therefore , [IL-1beta] *induces* both a pro- and an anti-inflammatory response in pediatric PMs , whereas adult produce only pro-inflammatory cytokines in response to IL-1beta . Positive_regulation IL1B PNMA1 22053092 2557282 Biochemical inhibition of , but not JNK or MAPK14 , *reduced* LPS induced [IL1B] , IL6 , and IL8 expression in endometrial cells . Positive_regulation IL1B POLDIP2 10903806 713235 We conclude that [IL-1 beta] *induces* activation of both and ERK1/2 , and that ERK1/2 contributes to the pro-apoptotic effects of the cytokine in primary beta-cells . Positive_regulation IL1B POLDIP2 12649265 1080006 [Interleukin-1beta] *induced* the phosphorylation of p38alpha and MAPK in cardiomyocytes and stimulated RNA polymerase II binding to the COX-2 promoter , COX-2 transcription , COX-2 protein synthesis , and prostaglandin E2 ( PGE2 ) release . Positive_regulation IL1B POLDIP2 12826666 1134594 Studies with specific inhibitors of MAPKs showed that MAPK activation was *necessary* for both [IL-1 beta] and MMP-1 induction , but Erk activation was required only for MMP-1 induction . Positive_regulation IL1B POLDIP2 15597323 1361723 Simultaneous addition of both inhibitors resulted in low levels of IL-1 beta , suggesting that CD33 exerts an inhibitory role mediated by PI3K , while MAPK signaling is *required* for [IL-1 beta] production . Positive_regulation IL1B POLDIP2 16271232 1479212 Similarly , the increased gene expression of proinflammatory cytokines TNF-alpha and [IL-1beta] in gastric mucosa induced by WIR stress were significantly *diminished* by MAPK inhibition . Positive_regulation IL1B PON1 19034653 2093269 ROS in the colon , the level of [interleukin 1 beta (IL-1 beta)] in colonic mucosa , serum tumor necrosis factor a ( TNF-alpha ) , MPO , and MDA were significantly *increased* in DSS treated animals ( P < 0.01 ) , with decreased activity ( P < 0.01 ) . Positive_regulation IL1B POU2F1 9575225 502646 Transcriptional regulation of [interleukin-1beta] gene by interleukin-1beta itself is *mediated* in part by in thymic stromal cells . Positive_regulation IL1B PPP1R3B 20153259 2248509 Using PBMC from healthy individuals , we show that monocytes differentiated with IL-15 ( IL15-DC ) produced [IL-1beta] , IL-6 , IL-15 , IL-23 , TNFalpha and CCL20 in *response* to and activated contact dependent Th17 and Th1 responses from autologous CD4 ( + ) T cells . Positive_regulation IL1B PRKAA1 19853624 2196676 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( [IL-1 beta] , TNF-alpha ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Positive_regulation IL1B PRKAA2 19853624 2196677 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( [IL-1 beta] , TNF-alpha ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Positive_regulation IL1B PRKAB1 19853624 2196678 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( [IL-1 beta] , TNF-alpha ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Positive_regulation IL1B PRKAB2 19853624 2196679 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( [IL-1 beta] , TNF-alpha ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Positive_regulation IL1B PRKAG1 19853624 2196680 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( [IL-1 beta] , TNF-alpha ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Positive_regulation IL1B PRKAG2 19853624 2196681 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( [IL-1 beta] , TNF-alpha ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Positive_regulation IL1B PRKCA 11478844 842090 PTH , tumor necrosis factor-alpha (TNF-alpha) , and [interleukin-1 beta (IL-1 beta)] *induced* translocation of and -beta ( I ) to the plasma membrane in UMR-106 cells within 5 min . Positive_regulation IL1B PRKCA 17426109 1766238 Data from inhibitor and small interfering RNA experiments indicate that [IL-1beta] release under HG is *mediated* by , via phosphorylation of p38 MAPK , and ERK1/2 leading to NF-kappaB activation , resulting in increased mRNA and protein for IL-1beta . Positive_regulation IL1B PRKCB 11478844 842091 PTH , tumor necrosis factor-alpha (TNF-alpha) , and [interleukin-1 beta (IL-1 beta)] *induced* translocation of ( I ) to the plasma membrane in UMR-106 cells within 5 min . Positive_regulation IL1B PRKCD 11549843 856885 [Interleukin-1 beta] *induced* synthesis of and protein kinase C-epsilon in EL4 thymoma cells : possible involvement of phosphatidylinositol 3-kinase . Positive_regulation IL1B PRKCE 11549843 856886 [Interleukin-1 beta] *induced* synthesis of protein kinase C-delta and in EL4 thymoma cells : possible involvement of phosphatidylinositol 3-kinase . Positive_regulation IL1B PRKCZ 18973186 2078971 Furthermore , UA suppressed the [IL-1beta] or TNF-alpha induced *activation* of . Positive_regulation IL1B PRL 18187558 1870163 AG490 , inhibitor of JAK2 , down-regulated transcription factors c-jun and STAT1 and inhibited the *induced* IFN-gamma , TNF-alpha , [IL-1 beta] and IL-12p40 production in macrophages . Positive_regulation IL1B PRL 8963751 343709 The absence of a comparable change in the progesterone release rate of males infused with IL-1 beta , and the presence of marked surges of prolactin (PRL) in the females , suggests that [IL-1 beta] altered ovarian function , and that the persistence of large corpora lutea *induced* release . Positive_regulation IL1B PROK2 18957080 1989369 When added in vitro to Con-A stimulated splenocytes , significantly *increased* [IL-1beta] and decreased IL-4 and IL-10 ; Positive_regulation IL1B PRPS1 17590158 1792412 Activation of with calcium and thrombin *triggered* an immediate release of VEGF , PDGF-BB and TGF-beta and a delayed release of [IL-1beta] in PRP supernatants . Positive_regulation IL1B PRPS2 17590158 1792413 Activation of with calcium and thrombin *triggered* an immediate release of VEGF , PDGF-BB and TGF-beta and a delayed release of [IL-1beta] in PRP supernatants . Positive_regulation IL1B PTBP1 10570261 568267 , unlike B cells , were *induced* to increase expression of [IL-1beta] , IL-1Ra , IL-8 , IL-12 p40 , RANTES , macrophage inflammatory protein-1alpha , and monocyte chemoattractant protein-1 after CD40 ligation . Positive_regulation IL1B PTBP1 10845914 700719 Altogether , these findings suggest that CD4 ( + ) and CD8 ( + ) T-lymphocyte subsets have distinct roles in the *induction* of [IL-1beta] secretion by and support the hypothesis that IL-1beta plays a role in cell mediated immune responses . Positive_regulation IL1B PTBP1 10861035 705059 The ligation of as well as Con A blasts by IL-12 *induced* the production of GM-CSF , [IL-1beta] , IL-6 , TNF-alpha , and IFN-gamma at the transcription levels . Positive_regulation IL1B PTBP1 14666382 1242538 Monocyte derived were generated in a culture of monocyte with interleukin 4 (IL-4) and granulocyte-macrophage colony stimulating factor , and the maturation of DCs was *induced* by either lipopolysaccharide (LPS) or a proinflammatory cytokine cocktail : tumor-necrosis factor alpha , prostaglandin E2 , IL-6 , and [IL-1beta] . Positive_regulation IL1B PTBP1 16622206 1551625 In addition , Campylobacter infected triggered activation of NF-kappaB and significantly *stimulated* production of [interleukin-1beta (IL-1beta)] , IL-6 , IL-8 , IL-10 , IL-12 , gamma interferon , and tumor necrosis factor alpha (TNF-alpha) compared to uninfected DCs . Positive_regulation IL1B PTBP1 20386470 2245274 LPS stimulation of *induced* IL-10 , IL-12p70 , TNFalpha and [IL-1beta] secretion , and taxol pretreatment modified this response by down regulating IL-1beta secretion whereas colchicine induced a proinflammatory cytokine profile with reduced IL-10 and increased IL-12p70 and TNFalpha secretion . Positive_regulation IL1B PTBP2 10570261 568264 , unlike B cells , were *induced* to increase expression of [IL-1beta] , IL-1Ra , IL-8 , IL-12 p40 , RANTES , macrophage inflammatory protein-1alpha , and monocyte chemoattractant protein-1 after CD40 ligation . Positive_regulation IL1B PTBP2 10845914 700716 Altogether , these findings suggest that CD4 ( + ) and CD8 ( + ) T-lymphocyte subsets have distinct roles in the *induction* of [IL-1beta] secretion by and support the hypothesis that IL-1beta plays a role in cell mediated immune responses . Positive_regulation IL1B PTBP2 10861035 705056 The ligation of as well as Con A blasts by IL-12 *induced* the production of GM-CSF , [IL-1beta] , IL-6 , TNF-alpha , and IFN-gamma at the transcription levels . Positive_regulation IL1B PTBP2 14666382 1242535 Monocyte derived were generated in a culture of monocyte with interleukin 4 (IL-4) and granulocyte-macrophage colony stimulating factor , and the maturation of DCs was *induced* by either lipopolysaccharide (LPS) or a proinflammatory cytokine cocktail : tumor-necrosis factor alpha , prostaglandin E2 , IL-6 , and [IL-1beta] . Positive_regulation IL1B PTBP2 16622206 1551622 In addition , Campylobacter infected triggered activation of NF-kappaB and significantly *stimulated* production of [interleukin-1beta (IL-1beta)] , IL-6 , IL-8 , IL-10 , IL-12 , gamma interferon , and tumor necrosis factor alpha (TNF-alpha) compared to uninfected DCs . Positive_regulation IL1B PTBP2 20386470 2245271 LPS stimulation of *induced* IL-10 , IL-12p70 , TNFalpha and [IL-1beta] secretion , and taxol pretreatment modified this response by down regulating IL-1beta secretion whereas colchicine induced a proinflammatory cytokine profile with reduced IL-10 and increased IL-12p70 and TNFalpha secretion . Positive_regulation IL1B PTGER3 12031964 947867 Sodium salicylate also prevented IL-1beta from inducing and cyclooxygenase (COX)-2 gene expression in islets and thereby *prevented* [IL-1beta] from inhibiting glucose induced insulin secretion . Positive_regulation IL1B PTGES 12512699 1027684 [Interleukin 1beta] *induces* functional in cultured human umbilical vein endothelial cells . Positive_regulation IL1B PTGES 16766159 1654010 The results showed that [IL-1beta] and TNFalpha *induce* the expression of without inducing the expression of early growth response factor-1 (Egr-1) . Positive_regulation IL1B PTGES3 12732209 1087105 *upregulates* expression levels of interleukin (IL)-1alpha , [IL-1beta] , IL-6 , IL-8 , and granulocyte-macrophage colony stimulating factor in normal human fibroblasts . Positive_regulation IL1B PTGS1 11108281 756831 After 4 h of stimulation , [IL-1beta] *induced* gene expression of cyclooxygenase-2 (COX-2) but not . Positive_regulation IL1B PTGS1 11863390 917486 We have shown that [IL-1 beta] *induces* the in vitro expression of genes believed to play important role in ovulation ( IL-1 beta itself , its receptors , IL-1 beta receptor antagonist , glucose transporters 1 and 3 , secretory and cytosolic phospholipase A(2) , and 2 ) . Positive_regulation IL1B PTGS1 7873203 296657 These results indicate that [IL-1 beta] *induces* cyclooxygenase-2 rather than in IMR-90 cells and this induction is responsible for the augmentation of PGE2 production stimulated with IL-1 beta . Positive_regulation IL1B PTGS2 10082276 597718 [Interleukin-1beta] *induced* but not cyclooxygenase-1 protein . Positive_regulation IL1B PTGS2 10383598 624629 Pretreatment with dexamethasone abolished [IL-1beta-] and BK-stimulated *induction* in all cells studied . Positive_regulation IL1B PTGS2 10383598 624631 Both [IL-1beta] and BK *induced* expression in all cells studied and this induction was blocked by dexamethasone . Positive_regulation IL1B PTGS2 10999850 734383 Cultured myometrial cells expressed low levels of Cox-2 mRNA under baseline conditions , but interleukin-1beta (IL-1beta) caused a 17-fold induction of expression of the transcript after incubation for 6 h . [IL-1beta] also *induced* expression of biologically active Cox-2 protein , as detected by immunofluorescence , Western blot analysis , and measuring the conversion of arachidonic acid to prostanoids in the presence and absence of a Cox-2-selective inhibitor , NS-398 . Positive_regulation IL1B PTGS2 11032891 740418 [Interleukin-1beta] *induces* and prostaglandin E ( 2 ) synthesis in human neuroblastoma cells : involvement of p38 mitogen activated protein kinase and nuclear factor-kappaB . Positive_regulation IL1B PTGS2 11053030 745145 These results are consistent with the hypothesis that p38 is involved in the signal transduction pathway through which [IL-1 beta] *induces* expression , PGE ( 2 ) release , and beta-adrenergic hyporesponsiveness . Positive_regulation IL1B PTGS2 11108281 756832 After 4 h of stimulation , [IL-1beta] *induced* gene expression of but not cyclooxygenase-1 (COX-1) . Positive_regulation IL1B PTGS2 11250126 793698 [Interleukin-1beta] *induced* expression and prostaglandin E2 secretion by human neuroblastoma cells : implications for Alzheimer 's disease . Positive_regulation IL1B PTGS2 11286988 799901 In monolayers , [interleukin-1beta (IL-1beta)] *induced* and NOS II expression in a dose- and time dependent manner , to produce high prostaglandin E ( 2 ) ( PGE ( 2 ) ) and nitrite ( NO ( 2 ) ( - ) ) levels in an apparently coordinated fashion . Positive_regulation IL1B PTGS2 11286988 799905 These results show that in chondrocytes : ( i ) and NOS II genes are *induced* sequentially and distinctly by [IL-1beta] ; Positive_regulation IL1B PTGS2 11530235 853780 [Interleukin 1beta] *induced* both nitric oxide synthase 2 (NOS-2) and gene expression in dorsal root ganglion explant culture with increased NOS-2 and COX-2 activities , and corresponding increases in the production of nitric oxide and prostaglandin E ( 2 ) . Positive_regulation IL1B PTGS2 11686835 875878 [Interleukin-1beta] *induces* expression in gastric cancer cells by the p38 and p44/42 mitogen activated protein kinase signaling pathways . Positive_regulation IL1B PTGS2 11853544 913350 Moreover , [IL-1beta] *induced* expression at 0.01 ng/ml in ( alg+ ) cells , whereas a 100-fold higher dose of cytokine was necessary for stimulation in ( alg- ) cells . Positive_regulation IL1B PTGS2 11854442 913963 The results of this study indicate that in human amnion cells , [IL-1 beta] might activate PLD through an upstream protein kinase C to elicit p38 and finally *induce* expression . Positive_regulation IL1B PTGS2 12124863 965847 [IL-1 beta] *induced* robust expression of and PGE ( 2 ) in OA meniscus , synovial membrane , and osteophytic fibrocartilage explants , whereas low levels were produced in OA articular cartilage . Positive_regulation IL1B PTGS2 12435328 1015841 Data showed that , as expected , [IL-1beta] *induced* both and PGE ( 2 ) production . Positive_regulation IL1B PTGS2 12529415 1048782 [IL-1beta] ( 1 ng/ml ) *induced* the expression of protein 6 h after treatment , accompanied by a 7.5-fold increase in PGE ( 2 ) production . Positive_regulation IL1B PTGS2 12568957 1057192 [IL-1 beta] *induces* , MMP-1 , -3 and -13 , ADAMTS-4 , IL-1 beta and IL-6 in human tendon cells . Positive_regulation IL1B PTGS2 12839952 1108188 These data demonstrate that [IL-1 beta] *induces* expression in HT-29 cells through multiple signaling pathways and NF-kappa B . Positive_regulation IL1B PTGS2 12892443 1117788 The results showed that lipopolysaccharide and tumor necrosis factor alpha , or TNF-alpha , induced COX-2 in macrophages , while [IL-1beta] and TNF-alpha *induced* in oral epithelial cells . Positive_regulation IL1B PTGS2 14645533 1173019 Bradykinin and [interleukin-1beta (IL-1beta)] *induce* in human airway smooth muscle cells . Positive_regulation IL1B PTGS2 14684367 1225379 In estrogen-deficient rats , [IL-1beta] *induced* cerebrovascular protein expression ; a peak response occurred 3 h after injection . Positive_regulation IL1B PTGS2 14749287 1204479 Given that hyperglycemia has been reported to increase human beta-cell production of [interleukin-1beta] and that this cytokine can *induce* expression , our observations of glucose induced induction of COX-2 in human islets suggest that this is one route through which hyperglycemia may contribute to beta-cell dysfunction . Positive_regulation IL1B PTGS2 14996278 1216219 [IL-1beta] also *induced* expression in gingival fibroblasts , and PGE2 , a major COX-2 product , was found to enhance MMP-1 expression . Positive_regulation IL1B PTGS2 15621371 1358431 These results indicate that TNFalpha and [IL-1beta] *induce* the functional expression of but not EP receptors in DRG cells in culture and suggest that cytokine induced sensitization of sensory neurons is secondary to prostaglandin production and not alterations in EP receptors . Positive_regulation IL1B PTGS2 15727891 1377056 In addition , [IL-1beta] *induced* expression by the cultured cells , as shown by Western blotting . Positive_regulation IL1B PTGS2 16123165 1482287 Inhibition of JNK or activities *prevents* [IL-1beta] induction of IL and StARD5 mRNAs and subsequent increases in StARD1 mRNA ( 24 h ) , indicating that these effects depend on the activation of both enzymes . Positive_regulation IL1B PTGS2 16277686 1480509 Real-time PCR analysis showed that [IL-1beta] *induced* expression maximally ( 37-fold ) at 12 hours and mPGES-1 expression maximally ( 68-fold ) at 24 hours . Positive_regulation IL1B PTGS2 16428068 1515852 Moreover , NS-398 suppressed the anti-apoptotic activity of IL-8 and [IL-1beta] , but did not *induce* ; Positive_regulation IL1B PTGS2 17015748 1629892 [IL-1beta] *induced* increased mRNA levels of MIP-2 , MCP-1 , RANTES , inducible NO synthase (iNOS) , and in the IEC-18 cell line . Positive_regulation IL1B PTGS2 17074047 1638008 [IL-1beta] protein expression was *induced* in macrophages in the meningis and perivascular space after leptin treatment , whereas induction was observed in endothelial cells , indicating the roles for these non-neuronal cells in mediating inflammatory actions of leptin . Positive_regulation IL1B PTGS2 17328065 1711911 PGE ( 2 ) formation and protein expression were *induced* by [IL-1beta] and potentiated by kinins with affinity for the B1 or B2 receptors , resulting in PGE ( 2 ) -dependent enhancement of RANKL . Positive_regulation IL1B PTGS2 18174279 1883130 [IL-1beta] similarly *induced* expression of , but the cyclooxygenase-2 expression was , in contrast , further enhanced by IL-1 receptor antagonist . Positive_regulation IL1B PTGS2 19452719 2084477 Hypoxia and/or [IL-1beta] effectively *induce* expression and PGE2 release in HNE . Positive_regulation IL1B PTGS2 19580863 2142580 Inhibition of markedly *reduced* both [IL-1 beta] and IL-6 release . Positive_regulation IL1B PTGS2 20424388 2262548 Thus , [IL-1beta] *induces* through the ERK mediated pathway in adventitial fibroblasts and macrophages of healthy aortae ; Positive_regulation IL1B PTGS2 20582811 2280521 PBMCs were treated with various concentrations of curcumin , resveratrol and parthenolide and tested for the abilities of these natural products to protect against the LPS induced expression , secretion of the pro-inflammatory cytokines TNFalpha , [IL-1beta] and IL-6 and *activation* of the pro-inflammatory . Positive_regulation IL1B PTGS2 7873203 296658 These results indicate that [IL-1 beta] *induces* rather than cyclooxygenase-1 in IMR-90 cells and this induction is responsible for the augmentation of PGE2 production stimulated with IL-1 beta . Positive_regulation IL1B PTGS2 8526991 336631 [Interleukin-1 beta] *induces* in cultured human decidual cells . Positive_regulation IL1B PTGS2 8543370 331245 The study indicates that the [IL-1 beta] induced PGE2 formation is *mediated* by an enhanced gene expression of in gingival fibroblasts suggesting that the enzyme COX-2 may play an important role in the regulation of prostanoid formation at inflammatory lesions in gingival tissue . Positive_regulation IL1B PTGS2 8606975 342722 For example , in amnion cells [interleukin-1 beta] *induces* a rapid increase in mRNA levels followed by a decrease to undetectable levels within 4 h of treatment ; Positive_regulation IL1B PTGS2 8632179 361553 [Interleukin-1 beta] *induces* ( cyclooxygenase-2 ) in primary murine astrocyte cultures . Positive_regulation IL1B PTGS2 9452008 475514 Both platelet activating factor and [interleukin-1beta] , potent mediators of the inflammatory and immune response , strongly *induce* transcription of the gene in brain cells . Positive_regulation IL1B PTGS2 9467571 485620 [Interleukin-1 beta] *induces* gene expression in cultured endometrial stromal cells . Positive_regulation IL1B PTGS2 9467571 485623 activity was *induced* by [IL-1 beta] ( 1 ng/mL ) ; Positive_regulation IL1B PTGS2 9515807 492236 Consistent with these findings , [IL-1beta] *induced* mRNA expression and protein production in A549 cells . Positive_regulation IL1B PTGS2 9571196 501689 [IL-1 beta] *induced* but not COX-1 protein . Positive_regulation IL1B PTGS2 9728043 530013 In summary , our results indicate that [IL-1beta] significantly increases prostanoid release by HASM cells as a *result* of increased expression . Positive_regulation IL1B PTGS2 9863663 556124 *Role* of induction in [interleukin-1beta] induced attenuation of cultured human airway smooth muscle cell cyclic AMP generation in response to isoprenaline . Positive_regulation IL1B PTGS2 9863663 556128 We investigated the *role* of induction and prostanoid release ( measured as PGE2 ) in [IL-1beta] induced attenuation of cyclic AMP generation in response to the beta-adrenoceptor agonist isoprenaline ( ISO ) . Positive_regulation IL1B PTHLH 11011119 752637 TNF-alpha or [IL-1beta] *induced* both G-CSF and production in the conditioned medium . Positive_regulation IL1B PTK2 10657625 664084 OX8 ( CD8 alpha ) -induced TNF and [IL-1 beta] production by macrophages was *blocked* by inhibitors of ( s ) , PP1 , and genistein , but not by phosphatidylinositol-3 kinase inhibitor , wortmannin . Positive_regulation IL1B PTK2 11775830 766430 *Role* of in [IL-1 beta] induced activation of mitogen activated protein kinase in fibroblast-like synoviocytes of rheumatoid arthritis . Positive_regulation IL1B PTK2 7519214 265512 The results suggest that TNF-alpha and [IL-1 beta] secretion after LPS stimulation of human monocytes *requires* the activation of and PKC , upstream to the activation of gene transcription . Positive_regulation IL1B PTK2 8188366 256771 Finally , our results , obtained with protein tyrosine kinase inhibitors and antiphosphotyrosine Western blotting ( immunoblotting ) , indicate that is *involved* in MAM induced [IL-1 beta] and TNF-alpha gene expression in the THP-1 monocytic cell line . Positive_regulation IL1B PTK2 8299229 248442 PTK and PKC activation plays a role in the induction of monokine gene transcription by SE because inhibitors of and PKC *reduced* TSST-1 stimulated [IL-1 beta] and TNF-alpha gene expression . Positive_regulation IL1B PTK2 9230816 444766 Modulation of [IL-1 beta] and TNF-alpha receptors by VLA-5 and VLA-6 *required* activation as herbimycin A ( 10 micrograms/mL ) blocked the affect of Fn and Ln . Positive_regulation IL1B PTK6 10657625 664085 OX8 ( CD8 alpha ) -induced TNF and [IL-1 beta] production by macrophages was *blocked* by inhibitors of ( s ) , PP1 , and genistein , but not by phosphatidylinositol-3 kinase inhibitor , wortmannin . Positive_regulation IL1B PTK6 11775830 766431 *Role* of in [IL-1 beta] induced activation of mitogen activated protein kinase in fibroblast-like synoviocytes of rheumatoid arthritis . Positive_regulation IL1B PTK6 7519214 265513 The results suggest that TNF-alpha and [IL-1 beta] secretion after LPS stimulation of human monocytes *requires* the activation of and PKC , upstream to the activation of gene transcription . Positive_regulation IL1B PTK6 8188366 256772 Finally , our results , obtained with protein tyrosine kinase inhibitors and antiphosphotyrosine Western blotting ( immunoblotting ) , indicate that is *involved* in MAM induced [IL-1 beta] and TNF-alpha gene expression in the THP-1 monocytic cell line . Positive_regulation IL1B PTK6 8299229 248443 PTK and PKC activation plays a role in the induction of monokine gene transcription by SE because inhibitors of and PKC *reduced* TSST-1 stimulated [IL-1 beta] and TNF-alpha gene expression . Positive_regulation IL1B PTK6 9230816 444767 Modulation of [IL-1 beta] and TNF-alpha receptors by VLA-5 and VLA-6 *required* activation as herbimycin A ( 10 micrograms/mL ) blocked the affect of Fn and Ln . Positive_regulation IL1B PTK7 10657625 664086 OX8 ( CD8 alpha ) -induced TNF and [IL-1 beta] production by macrophages was *blocked* by inhibitors of ( s ) , PP1 , and genistein , but not by phosphatidylinositol-3 kinase inhibitor , wortmannin . Positive_regulation IL1B PTK7 11775830 766432 *Role* of in [IL-1 beta] induced activation of mitogen activated protein kinase in fibroblast-like synoviocytes of rheumatoid arthritis . Positive_regulation IL1B PTK7 7519214 265514 The results suggest that TNF-alpha and [IL-1 beta] secretion after LPS stimulation of human monocytes *requires* the activation of and PKC , upstream to the activation of gene transcription . Positive_regulation IL1B PTK7 8188366 256773 Finally , our results , obtained with protein tyrosine kinase inhibitors and antiphosphotyrosine Western blotting ( immunoblotting ) , indicate that is *involved* in MAM induced [IL-1 beta] and TNF-alpha gene expression in the THP-1 monocytic cell line . Positive_regulation IL1B PTK7 8299229 248444 PTK and PKC activation plays a role in the induction of monokine gene transcription by SE because inhibitors of and PKC *reduced* TSST-1 stimulated [IL-1 beta] and TNF-alpha gene expression . Positive_regulation IL1B PTK7 9230816 444768 Modulation of [IL-1 beta] and TNF-alpha receptors by VLA-5 and VLA-6 *required* activation as herbimycin A ( 10 micrograms/mL ) blocked the affect of Fn and Ln . Positive_regulation IL1B PTPN22 17114487 1651625 Both in vitro and in mice , *induced* MIP-2/IL-8 , TNF-alpha , and [IL-1beta] , all mediators of neutrophil recruitment and activation . Positive_regulation IL1B PTTG1IP 10892857 711310 Both [IL-1beta] and TNF-alpha *induced* a significant decrease in uPA expression in PBF , whereas bFGF induced a slight increase in both HJF and . Positive_regulation IL1B PTX3 17082642 1643422 also *up-regulated* expression of proinflammatory cytokines [IL-1beta] and TNF-alpha mRNA in Tg CNS . Positive_regulation IL1B PTX3 20231290 2254561 *increased* the expression of [IL-1beta] and AT1R through NF-kappaB , and a small GTP binding protein , Rac , mediated PTX induced NF-kappaB activation through NADPH oxidase dependent production of reactive oxygen species . Positive_regulation IL1B PTX4 17082642 1643421 also *up-regulated* expression of proinflammatory cytokines [IL-1beta] and TNF-alpha mRNA in Tg CNS . Positive_regulation IL1B PTX4 20231290 2254553 *increased* the expression of [IL-1beta] and AT1R through NF-kappaB , and a small GTP binding protein , Rac , mediated PTX induced NF-kappaB activation through NADPH oxidase dependent production of reactive oxygen species . Positive_regulation IL1B RAB39A 19833722 2169976 binds caspase-1 and is *required* for caspase-1 dependent [interleukin-1beta] secretion . Positive_regulation IL1B RAB39A 19833722 2169978 Finally , overexpression of *results* in an increase in [IL-1beta] secretion , and furthermore , overexpression of a Rab39a construct lacking the caspase-1 cleavage site leads to an additional increase in IL-1beta secretion . Positive_regulation IL1B RAC1 18684863 1973558 The small GTPase was activated by simvastatin , and this was *required* for both PKB activation and [IL-1beta] secretion . Positive_regulation IL1B RAC1 18684863 1973564 Importantly , inhibition of in peripheral blood mononuclear cells isolated from MKD patients *resulted* in a dramatic reduction in [IL-1beta] release . Positive_regulation IL1B REL 10936515 720688 Dexamethasone *inhibits* [IL-1 beta] gene expression in LPS stimulated RAW 264.7 cells by blocking NF-kappa and AP-1 activation . Positive_regulation IL1B REL 14670622 1188986 These results suggest that AAF *inhibits* [IL-1beta] gene expression by blocking activation . Positive_regulation IL1B RELA 10074208 594748 In contrast , infection with EZ did not block *activation* of the transcription factor by [IL-1beta] . Positive_regulation IL1B RELA 10089132 600013 PD 098059 , a selective inhibitor of the ERK activating kinase MEK1 , had no effect on IL-1beta induced MCP-1 mRNA or protein levels , or on [IL-1beta] *activation* of . Positive_regulation IL1B RELA 10232679 611401 Treatment with N ( G ) -nitro-L-arginine methyl ester ( L-NAME ) did not affect initial *activation* of by [IL-1beta/TNF-alpha] , but unveiled an inhibitory effect of NO generation on NF-kappaB activity after 4 h . Positive_regulation IL1B RELA 10484338 643970 On the basis of previous work demonstrating nitric oxide ( NO ) -mediated inhibition of nuclear factor-kappaB (NF-kappaB) DNA binding , we hypothesized that NO downregulates *dependent* [interleukin-1beta (IL-1beta)] production in an ANA-1 macrophage model of lipopolysaccharide (LPS) stimulation . Positive_regulation IL1B RELA 10614986 575773 It has been shown that B1-receptor induction during inflammation involves [interleukin-1beta (IL-1beta)] production and *activation* of . Positive_regulation IL1B RELA 10619820 657342 Inhibition of by pyrrolidine dithiocarbamate *attenuated* [IL-1beta] and TNF-alpha synthesis . Positive_regulation IL1B RELA 10707928 673454 In PANC-1 cells , [IL-1beta] and TNF-alpha *induced* a rapid activation of , and TGF-beta1 enhanced this activation slightly . Positive_regulation IL1B RELA 10881930 709230 [IL-1beta] and TNF-alpha *induced* a rapid activation of in PANC-1 cells , and the increase in chemokine mRNA expression correlated with NF-kappaB activation . Positive_regulation IL1B RELA 10884313 709539 However , pretreatment with oATP downregulated *activation* of and AP-1 by [IL-1beta] or TNFalpha . Positive_regulation IL1B RELA 10936515 720689 Dexamethasone *inhibits* [IL-1 beta] gene expression in LPS stimulated RAW 264.7 cells by blocking and AP-1 activation . Positive_regulation IL1B RELA 11020244 737833 The p106 and p112 proteins bound to NF-kappaB , and their levels changed during the transient [interleukin-1beta] *activation* of in HT-29 cells . Positive_regulation IL1B RELA 11104703 756500 Taken together , these findings indicate that , by using a proteasome dependent mechanism , [IL-1beta] concomitantly *induces* activation and dephosphorylates IL-6 activated STAT1 ; Positive_regulation IL1B RELA 11264769 796661 An inhibition of by pyrrolidine dithiocarbamate *attenuated* [IL-1beta] and TNF-alpha synthesis . Positive_regulation IL1B RELA 11274229 797584 These data suggested that ( 1 ) constitutive and [IL-1beta-inducible] expression of MCP-1 was differently *regulated* by AP-1 and and ( 2 ) t-RA inhibited selectively the constitutive expression of MCP-1 via intervention in the AP-1 pathway . Positive_regulation IL1B RELA 11466367 839962 Additional data are provided indicating that the *activation* of by [IL-1beta] is also responsible for the inhibition of other IL-6-inducible genes , such as the alpha(1)-antichymotrypsin gene as well as the suppressor of cytokine signaling 3 gene , suggesting a more general relevance of this mechanism for transcriptional regulation . Positive_regulation IL1B RELA 11698503 878185 In naive cells , LPS , TNF-alpha , and [IL-1beta] *induced* IkappaBalpha degradation , kinase phosphorylation , and DNA binding . Positive_regulation IL1B RELA 11742864 887437 [IL-1beta] *induced* a rapid and transient activation of , followed by a prolonged activation of NF-kappaB that was required to induce iNOS expression . Positive_regulation IL1B RELA 11916194 925464 The inhibition of activation markedly *blocked* both [IL-1beta-] and TNF-alpha induced IL-8 and MCP-1 mRNA expression , but did not affect MMP-1 mRNA expression . Positive_regulation IL1B RELA 11930628 894639 Enhancement of activity of and AP-1 may positively *regulate* the production of IL-8 and [IL-1 beta] in the airflow obstruction . Positive_regulation IL1B RELA 11996950 939210 In addition , [IL-1beta] *induced* activation in VSMC , an effect that was increased by the addition of beta-VLDL . Positive_regulation IL1B RELA 12021045 942766 In this study , we investigated the possible *role* of the in [IL-1beta] signaling , leading to the expression of COX-2 in human amnion cell culture . Positive_regulation IL1B RELA 12219013 986609 The 2 groups of mice were analyzed for serum levels of interferon-gamma , tumor necrosis factor-alpha , and [interleukin-1beta] as well as *activation* of and STAT1 , 2 proinflammatory transcription factors . Positive_regulation IL1B RELA 12421347 1013464 In comparison , [IL-1beta] *induced* the release of PGE2 , IL-6 and activated , p38 , JNK and ERK1/2 in mixed glial cultures , but failed to induce any of these responses in microglial cell cultures . Positive_regulation IL1B RELA 12509805 1038771 Finally , [IL-1beta] and TNF-alpha *induced* degradation of 's bound inhibitory protein , IkappaB-alpha , leading to translocation of NF-kappaB into the nucleus . Positive_regulation IL1B RELA 12528110 1048603 Activation of was *induced* by [IL-1 beta] , but not by MIF . Positive_regulation IL1B RELA 12594338 1064340 To further substantiate that the observed [IL-1 beta] *induction* of the human NK-1R gene is regulated via a transcriptional event through this NF-kappa B site on the NK-1R gene promoter , we transfected THP-1 cells with a luciferase promoter-reporter construct containing the 5 ' promoter region of the human NK-1R gene . Positive_regulation IL1B RELA 12676746 1076848 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that mitogen activated protein (MAP) kinase signaling and activation are *involved* in IL-1beta induced IL-6 production . Positive_regulation IL1B RELA 12839952 1108185 Supershift assay indicated that the two NF-kappa B subunits , p65 and p50 , were involved in *activation* of complex by [IL-1 beta] stimulation . Positive_regulation IL1B RELA 12898518 1118511 Our results suggest that activation in PIMs followed by phagocytizing lipopolysaccharide *resulted* in the up-regulation of TNF-alpha , [IL-1beta] , IL-6 , IL-8 , and COX-2 , which could be alleviated by dexamethasone . Positive_regulation IL1B RELA 14527367 1148358 mRNA expression of proinflammatory cytokines ( [IL-1 beta] , IL-6 , TNF-alpha , and MCP-1 ) and *activation* of of HMC were measured using Reverse transcription-polymerase chain reaction ( RT-PCR ) and electrophoretic mobility shift assay ( EMSA ) respectively . Positive_regulation IL1B RELA 14581482 1186940 Thus , although activation was *essential* for [interleukin-1beta] induction of each of the proteins studied , gene expression was differentially regulated by ERK and by the duration of NF-kappaB activation . Positive_regulation IL1B RELA 14652683 1173706 The analysis of IkappaB degradation and NF-kappaB translocation revealed that hypoxia did not affect [IL-1beta] *activation* of . Positive_regulation IL1B RELA 14670622 1188987 These results suggest that AAF *inhibits* [IL-1beta] gene expression by blocking activation . Positive_regulation IL1B RELA 14985981 1236665 The *activation* of by [IL-1beta] was maximal at 20 min and declined thereafter . Positive_regulation IL1B RELA 15001568 1236970 The inhibitory effect of angiotensin II on iNOS expression was associated with a down-regulation of the sustained *activation* of extracellular signal regulated kinase ( ERK ) and by [interleukin-1beta] , whereas the effect on VCAM-1 was independent of ERK activation . Positive_regulation IL1B RELA 15039421 1251225 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of [pro-IL-1beta] , and RIP2 dependent *activation* of and p38 MAPK mediated by the caspase recruitment domain . Positive_regulation IL1B RELA 15044702 1228280 Expression of [IL-1beta] in AF macrophages and *activation* of in the maternal uterus increased with the gestational increase in SP-A . Positive_regulation IL1B RELA 15063239 1230851 Our results suggest that elevated activation of , at least in part , *contributes* to the dysregulated expression of [IL-1beta] and iNOS in the lungs of senescent animals . Positive_regulation IL1B RELA 15146413 1247764 The mRNA up-regulation of IL-8 and [IL-1beta] by MIF was *inhibited* by 2 tyrosine kinase inhibitors , a protein kinase C ( PKC ) inhibitor , an activator protein 1 (AP-1) inhibitor , and by an inhibitor . Positive_regulation IL1B RELA 15240151 1270119 Interestingly , [IL-1beta] *induced* activation in A549 cells , which was shown by increased nuclear translocation of p65 NF-kappaB and degradation of IkappaB-alpha . Positive_regulation IL1B RELA 15662752 1350343 It became known , that oxidized LDL can inhibit LPS induced binding of the NF-kappaB to DNA and the subsequent expression of TNF-alpha and [interleukin-1beta] in macrophages as well as oxidized LDL modulates *activation* of in mononuclear phagocytes by altering the degradation of I-kappaBs . Positive_regulation IL1B RELA 15749024 1379452 Recombinant mouse [IL-1beta] *induced* strong activation of ERK1/2 , p38 , JNK and , and significant release of IL-6 and PGE2 , which was blocked by IL-1ra . Positive_regulation IL1B RELA 15980221 1424667 The *activation* of by [IL-1beta] was markedly inhibited by both triptolide and dexamethasone , whereas the activity of AP-1 was not affected by either agent . Positive_regulation IL1B RELA 16106402 1498852 Ursodeoxycholic acid inhibits [interleukin 1 beta] [ corrected ] and deoxycholic acid induced *activation* of and AP-1 in human colon cancer cells . Positive_regulation IL1B RELA 16148608 1455211 [Interleukin-1beta] *induced* activation in vascular smooth muscle cells , and the addition of GGA further inhibited this NF-kappaB activation . Positive_regulation IL1B RELA 16258248 1477785 It also inhibited NF-IL6- and induced *activation* of [IL-1beta] , with IC50 values of 78 nM and 1.6 microM , respectively , revealing a potent inhibitory effect on NF-IL6 . Positive_regulation IL1B RELA 16297883 1502772 Dioscorin also stimulated multiple signaling molecules ( , ERK , JNK , and p38 ) and *induced* the expression of cytokines ( TNF-alpha , [IL-1beta] , and IL-6 ) in murine RAW 264.7 macrophages . Positive_regulation IL1B RELA 16339279 1539612 Chromatin immunoprecipitation analysis revealed [IL-1beta] *induced* binding of to the PR promoter . Positive_regulation IL1B RELA 16399630 1513046 These results suggest that CHL *inhibits* [IL-1beta] production in macrophages stimulated with LPS at transcriptional level by blocking the phosphorylation of p38 and by suppressing the activation of transcription factors , , NF-IL6 , and AP-1 . Positive_regulation IL1B RELA 16556731 1589300 Both cytokines induced a prolonged ( up to 48 h ) and stable NF-kappaB activation in INS-1E cells , whereas [IL-1beta] *induced* an oscillatory activation in 208F cells . Positive_regulation IL1B RELA 16581045 1496465 Signal transduction studies revealed that [IL-1beta] and TNF-alpha stimulation *induced* phosphorylation in A549 cells , but antagonist inhibition of NFkappaB p50-p65 phosphorylation correlated with marked reduction of IL-1beta or TNF-alpha induced CCL28 expression . Positive_regulation IL1B RELA 16778360 1576827 However , both [IL-1beta] and IL-6 mRNA induction was *suppressed* by inhibitors . Positive_regulation IL1B RELA 16822942 1638583 In conclusion , in the ERK signaling cascade , RSK1 is a key component that directly phosphorylates IkappaBbeta and contributes to the persistent *activation* of by [IL-1beta] . Positive_regulation IL1B RELA 16858424 1625430 In HaCaT cells and in reconstructed human epidermis ( RHE ) , FasL triggered a *dependent* mRNA accumulation of inflammatory cytokines ( tumor necrosis factor-alpha , IL-6 , and [IL-1beta] ) , chemokines ( CCL2/MCP-1 , CXCL1/GROalpha , CXCL3/GROgamma , and CXCL8/IL-8 ) , and the adhesion molecule ICAM-1 . Positive_regulation IL1B RELA 17097317 1709064 is *required* for [IL-1beta] stimulation of Matrix Metalloproteinase-1 expression in chondrocytes . Positive_regulation IL1B RELA 17135302 1716731 ROS and but not LXR *mediate* [IL-1beta] signaling for the downregulation of ATP binding cassette transporter A1 . Positive_regulation IL1B RELA 17189835 1680274 Compared to wild-type mice , the obese mice exhibited higher levels of phosphorylation of these proteins , greater *activation* of , and higher levels of circulating proinflammatory cytokines , including TNF-alpha , [IL-1beta] and IL-6 , on UVB irradiation . Positive_regulation IL1B RELA 17227815 1703850 However , inhibition of the RhoA/Rho-kinase pathway did not attenuate the *activation* of by [IL-1beta] . Positive_regulation IL1B RELA 17473513 1738343 Mutations of cyropyrin lead to the persistent production of [IL-1beta] and *activation* of , followed by excessive inflammtory reactions . Positive_regulation IL1B RELA 17501665 1783814 In contrast , was not *essential* for [IL-1beta] induction of OPG . Positive_regulation IL1B RELA 18300858 1873450 However , the high concentration of D-glucose did increase iNOS expression in response to low concentrations of [IL-1beta] ( 2.5 and 5 ng/ml ) , as well as the IL-1beta induced *activation* of both ERK 1/2 and . Positive_regulation IL1B RELA 18433103 1920791 It was previously demonstrated that stevioside attenuates *dependent* TNF-alpha and [IL-1beta] synthesis in LPS stimulated monocytes . Positive_regulation IL1B RELA 18456659 1933010 TAB4 mutated at Phe-Pro dominantly interfered with [IL-1beta] *activation* of involving IKK dependent but not p38 MAPK dependent signaling . Positive_regulation IL1B RELA 18547651 1940571 The activation of was *followed* by increased mRNA expression of TNF-alpha and [IL-1beta] peaking at about 20 h . Positive_regulation IL1B RELA 18599158 2208599 and ( 3 ) S100B/RAGE induced upregulation of COX-2 , [IL-1beta] and TNF-alpha expression *requires* the concurrent activation of and AP-1 . Positive_regulation IL1B RELA 19067146 2024077 The TNBS treatment caused colon shortening , increased myeloperoxidase activity , *induced* [IL-1beta] , TNF-alpha , and IL-6 expression in the colon , activated , and potentiated the GAG degrading activities of intestinal microflora . Positive_regulation IL1B RELA 19454703 2084579 In direct correlation with the increased viral internalization , antiviral Abs amplified the innate immune response to adenovirus as determined by the expression of *dependent* genes , type I IFNs , and caspase dependent [IL-1beta] maturation . Positive_regulation IL1B RELA 19474209 2085593 In addition , the A. fumigatus antigens induced production of [IL-1beta] and IL-10 in supernatants of corneal epithelial cells was also *attenuated* by inhibitor . Positive_regulation IL1B RELA 19521662 2108903 Transforming growth factor-beta activated kinase 1 ( TAK1 ) is a serine/threonine protein kinase that is critically involved in the *activation* of by tumor necrosis factor ( TNFalpha ) , [interleukin-1beta (IL-1beta)] and TLR ligands . Positive_regulation IL1B RELA 19648113 2143238 Injury induced platelet derived growth factor receptor-alpha expression mediated by [interleukin-1beta (IL-1beta)] release and cooperative *transactivation* by and ATF-4 : IL-1beta facilitates HDAC-1/2 dissociation from promoter . Positive_regulation IL1B RELA 19915568 2189966 Its production is tightly controlled by transcription of [Il1b] *dependent* on the transcription factor and subsequent processing of pro-IL-1 beta by an inflammasome . Positive_regulation IL1B RELA 19929594 2171914 IFN-gamma does not affect the transient *activation* of classical by [IL-1beta] and synergistic induction of ip-10 expression by IFN-gamma and IL-1beta occurs even after the activation of classical NF-kappaB has returned to basal levels . Positive_regulation IL1B RELA 20145375 2280996 [IL-1beta] ( 4 ng/ml , 10 min ) *induced* phosphorylation of , JNK , and ERK . Positive_regulation IL1B RELA 20181058 2222749 [IL-1beta] potently *induced* activation in CaCo-2 cells , but did not induce TLR-4 expression . Positive_regulation IL1B RELA 20369226 2261620 Saturated-fatty-acid induced activation and endoplasmic reticulum stress may *contribute* to [IL-1beta] production and mild islet inflammation in type 2 diabetes . Positive_regulation IL1B RELA 20398663 2293932 In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6 , [interleukin-1beta] , and tumor necrosis factor alpha ) and *activation* of MAPK and in Pirb-/- macrophages following bacterial activation . Positive_regulation IL1B RELA 23136298 2729441 As expected , [IL1B] *induced* transcriptional activity . Positive_regulation IL1B RELA 24009751 2836894 In this study , the probable pathway by which [IL1B] *induces* and affects gastrin expression has been elucidated . Positive_regulation IL1B RELA 7545088 318477 Here we demonstrate that [IL-1 beta] *induces* nuclear translocation of in human umbilical vein endothelial cells , followed by induction of cell surface expression of E-selectin , intercellular adhesion molecule-1 , and vascular adhesion molecule 1 , and subsequently augments adhesion of those cancer cells expressing sialyl Lewis X antigen , a ligand to E-selectin . Positive_regulation IL1B RELA 8021507 263079 *regulates* [IL-1 beta] transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site . Positive_regulation IL1B RELA 8074713 270568 In human astrocytoma and neuroblastoma cell lines tumour necrosis factor alpha (TNF alpha) and [interleukin 1 beta (IL-1 beta)] *induced* and an additional KB-specific protein of approximately 80 K to bind the HIV-1 enhancer . Positive_regulation IL1B RELA 8144314 242475 Therefore , we investigated whether cyclic AMP , protein kinase A and are *involved* in the induction of [IL-1 beta] release by human peripheral blood monocyte derived macrophages ( HPBM ) stimulated with a specific IL-1 beta inducer , 9-hydroxyoctadecadienoic acid ( 9-HODE ) . Positive_regulation IL1B RELA 8579596 350559 [IL-1 beta] rapidly *induced* the translocation of in rat mesangial cells . Positive_regulation IL1B RELA 8809309 383095 The aim now was to investigate whether recombinant ( r ) [IL-1 beta] *induces* the stimulation of and its inhibitor proteins in human gingival fibroblasts and to understand if inhibition of its activity affects collagenase gene expression . Positive_regulation IL1B RELA 8977194 408705 IL-1beta stimulated NF-kappaB nuclear translocation and *dependent* [IL-1beta] and IL-8 expression in both Caco-2 and HT-29 cells as assayed by electrophoretic mobility shift assay , immunofluorescence , kappaB-luciferase transfection , reverse transcriptase-PCR analysis and ELISA . Positive_regulation IL1B RELA 9079634 420545 *Role* of in tumor necrosis factor-alpha and [interleukin-1beta] regulation . Positive_regulation IL1B RELA 9332715 457649 The oxidative stress responsive transcription factor consists of a p50 ( 50 kDa ) and p65/RelA ( 65 kDa ) component and can be *activated* in vitro by TNF alpha , [IL1 beta] , hydrogen peroxide and oxygen radicals . Positive_regulation IL1B RELA 9510209 491888 The *role* of activation in BK-induced [IL-1beta] synthesis was demonstrated by the ability of BK to stimulate increased chloramphenicol acetyltransferase (CAT) activity in A549 cells transfected with a reporter plasmid containing three kappaB enhancers from the IL-1beta gene , while deletion of the kappaB enhancer sequences eliminated BK-stimulated CAT activity . Positive_regulation IL1B RELA 9681388 521079 Interleukin-1 mediated febrile responses in mice and [interleukin-1 beta] *activation* of in mouse primary astrocytes , involves the interleukin-1 receptor accessory protein . Positive_regulation IL1B RELA 9758209 536002 These results provide convincing evidence that may *mediate* the [IL-1beta] stimulation of PGHS-2 gene expression as well as the dexamethasone inhibition of the IL-1beta induction process in WISH cells . Positive_regulation IL1B RELA 9759860 536569 *Activation* of by [IL-1beta] was markedly less sensitive to both cPLA2 and sPLA2 inhibitors . Positive_regulation IL1B RELA 9798528 543547 Nuclear factor in myocardium : developmental expression of subunits and *activation* by [interleukin-1 beta] in cardiac myocytes in vitro . Positive_regulation IL1B REN 7538649 306856 [Interleukin-1 beta] *induces* the formation of nitric oxide in isolated juxtaglomerular cells : influence on secretion . Positive_regulation IL1B RENBP 16450750 1521999 Both AGE modified beta2m and significantly *increased* TNF-alpha and [IL-1beta] secretion by human PMO in a dose dependent manner ( 50-200 microg/ml ) . Positive_regulation IL1B RETN 18547319 1952255 In vitro , both leptin and could induce CXCL8 and tumour necrosis factor-alpha production by blood monocytes , and leptin could additionally *induce* [IL-1beta] and IL-1 receptor antagonist production . Positive_regulation IL1B RFX1 12558194 1029109 Treatment of animals with CLX or RFX did not alter the content of pro-inflammatory cytokines IL-1beta or TNF-alpha in the pleural exudate , but CLX reduced [IL-1beta] levels in the rat paw tissue and *increased* TNF-alpha in this tissue . Positive_regulation IL1B RGS16 14566449 1165128 [IL-1beta] ( 1.75-fold ) and TNFalpha ( 1.62-fold ) but not IL-6 and IFNgamma *induced* protein expression . Positive_regulation IL1B RHO 18038269 1894659 By using pharmacological inhibitors , it was suggested that G ( i ) activation and subsequent reactive oxygen species ( ROS ) production were *involved* in [IL-1 beta] induction . Positive_regulation IL1B RIPK2 11051551 743438 ICEBERG is a novel protein that *inhibits* generation of [IL-1beta] by interacting with caspase-1 and preventing its association with . Positive_regulation IL1B RIPK2 15039421 1251210 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of [pro-IL-1beta] , and dependent *activation* of NF-kappaB and p38 MAPK mediated by the caspase recruitment domain . Positive_regulation IL1B RIPK2 17348859 1733932 Thus pharmacological inhibition of RIP2 kinase with either SB 203580 [ a p38 MAPK ( mitogen activated protein kinase ) inhibitor ] or the Src family kinase inhibitor PP2 induces a rapid and drastic decrease in the level of the RIP2 protein , which may explain why these inhibitors *block* MDP stimulated downstream signalling and the production of [IL-1beta] ( interleukin-1beta ) and TNFalpha ( tumour necrosis factor-alpha ) . Positive_regulation IL1B RIPK2 17403772 1760727 Using mice bearing selective gene deletions , we provide in vitro and in vivo data showing that MDP induced [IL-1beta] release *requires* Nod2 and CIAS1/NALP3 as well as , apoptosis associated speck-like protein containing a caspase activation and recruitment domain ( ASC ) , and caspase-1 . Positive_regulation IL1B RNF19A 9624172 511380 Differential *roles* of extracellular signal regulated kinase-1/2 and ( MAPK ) in [interleukin-1beta-] and tumor necrosis factor-alpha induced low density lipoprotein receptor expression in HepG2 cells . Positive_regulation IL1B RPS15A 18950704 2014398 Furthermore , co-transfection study shows that HSP27 S78/82A , two phosphorylated serine site deficient mutants , but not wild-type HSP27 ( HSP27 WT ) and HSP27 mutant increases TRAF6 ubiquitination and thereby *mediates* [IL-1beta] triggered IKK phosphorylation . Positive_regulation IL1B RPS6KA1 16822942 1638581 In conclusion , in the ERK signaling cascade , is a key component that directly phosphorylates IkappaBbeta and *contributes* to the persistent activation of NF-kappaB by [IL-1beta] . Positive_regulation IL1B RUNX2 16549373 1582335 Furthermore , [IL-1beta] *induced* the phosphorylation of , and this effect was blocked by a p38 kinase inhibitor . Positive_regulation IL1B S100A12 11792459 901889 We found that substance P ( SP ) and ( 0.3-1 microM ) *increased* , in a concentration dependent manner , the basal secretion of [interleukin-1 beta (IL-1 beta)] , interleukin-6 (IL-6) , and tumor necrosis factor alpha (TNF alpha) from cultured lymphocyte enriched mononuclear cells isolated from human peripheral blood . Positive_regulation IL1B S100A12 12836161 1107900 The results showed that [IL-1beta] ( 1 ng/ml ) could directly *induce* release following prolonged incubation ( 24 hr ) with these neurons . Positive_regulation IL1B S100A12 12836161 1107921 These results indicate that [IL-1beta] may activate PKC , which in turn initiates JNK MAPK and activates NF-kappaB and finally *induces* gene expression and release from these sensory neurons . Positive_regulation IL1B S100A12 15319367 1303742 Proinflammatory factor [IL-1beta] *induces* release from neuron derived sources . Positive_regulation IL1B S100A12 15319367 1303744 However , whether [IL-1beta] can *induce* secretion from a nonneural source , AEII cells , is not known . Positive_regulation IL1B S100A12 17481780 1750507 In a previous study , we found that could be *induced* by proinflammatory factor [IL-1beta] in A549 human type II alveolar ( AEII ) epithelial cells . Positive_regulation IL1B S100A9 17237603 1690126 Further , *induced* [IL-1beta] production from neutrophils and the SW982 cells . Positive_regulation IL1B S100A9 19248102 2045038 in serum of patients with systemic-onset JIA was a strong *inducer* of [IL-1beta] expression in phagocytes . Positive_regulation IL1B S100B 11578775 865298 also *stimulated* both iNOS and [IL-1 beta] , although S100B83stop was significantly less effective than wild-type S100B in inducing iNOS . Positive_regulation IL1B S100B 15659225 1364821 We examined the gene-regulatory events through which *induces* [IL-1beta] expression . Positive_regulation IL1B S100B 15659225 1364822 But in primary cortical neurons , decoy and siRNA experiments indicated that the [IL-1beta] *induction* by was mediated by Sp1 without evidence of a role for NFkappaB . Positive_regulation IL1B S100B 18599158 2208587 We show here that : ( 1 ) S100B also stimulates AP-1 transcriptional activity in microglia via RAGE dependent activation of JNK; (2) *upregulates* [IL-1beta] and TNF-alpha expression in microglia via RAGE engagement ; Positive_regulation IL1B S100B 18599158 2208595 and ( 3 ) induced *upregulation* of COX-2 , [IL-1beta] and TNF-alpha expression requires the concurrent activation of NF-kappaB and AP-1 . Positive_regulation IL1B S100B 19042033 2023199 secretion was *induced* by [IL-1beta] in all preparations , involving MAPK pathway and , apparently , NF-small ka , CyrillicB signaling . Positive_regulation IL1B SAA1 10886778 709864 These findings are in contrast to the results obtained from hepatoma cell line HepG2 , in which [IL-1beta] alone could *induce* secretion , while dexamethasone supplemented FCS could not . Positive_regulation IL1B SAA1 11160347 781713 In the human experimental system , [IL-1beta] *induced* transcription of acute-phase ( A-SSA ; encoded by SAA1/SAA2 ) in primary chondrocytes . Positive_regulation IL1B SAA1 16483749 1534805 *induced* dose dependent production of TNF-alpha and [IL-1 beta] in HMC-1 cells . Positive_regulation IL1B SAA1 19223523 2071994 [IL-1beta] , TNF-alpha , and human AT macrophage conditioned medium significantly *induced* secretion ( from 2.6 to 7.6 fold ) in hMADS cells . Positive_regulation IL1B SAA1 19850938 2187500 Interestingly , *activated* smooth muscle cell [IL-1beta] mRNA expression , however , blocking IL-1 receptors had no effect on SAA mediated activation of sPLA ( 2 ) expression . Positive_regulation IL1B SAA1 21508263 2428611 Blocking TLR2 and TLR4 attenuated *induced* expression of [IL1B] , whereas inhibition of caspase-1 and the ATP receptor P2X(7) abrogated the release of mature IL-1ß . Positive_regulation IL1B SAA1 2454996 93468 These results indicate that human and CRP are *induced* in Hep 3B cells by products of activated monocytes but not by [IL-1 beta] , TNF-alpha , or some hepatocyte stimulating factor preparations and that a group of heterogeneous mechanisms are involved in the induction of the various human APP . Positive_regulation IL1B SAA1 9256609 448379 [IL-1 beta] *induced* both CRP and production but only in the co-presence of IL-6 . Positive_regulation IL1B SAA2 9149805 430074 The IL-1 receptor antagonist , hIL-1ra , can specifically block the [IL-1 beta] driven transcriptional *activation* of , but not that driven by TNF-alpha or IL-6 . Positive_regulation IL1B SAA3P 18452164 1938763 Furthermore , [IL-1beta] significantly *induced* mRNA expression dose-dependently with maximal 36.4-fold upregulation seen at 2 ng/ml effector . Positive_regulation IL1B SCN8A 15115299 1241496 On the contrary , a single significantly *enhanced* mRNA levels of interleukin-1alpha (IL-1alpha) , [IL-1beta] ( P < 0.02 ) and plasminogen activator inhibitor-1 ( P < 0.05 ) . Positive_regulation IL1B SCNN1A 19136575 2037706 was *induced* by [IL-1beta] at GD61 and increased late during gestation . Positive_regulation IL1B SEA 8003022 257885 Unlike MAM induced IL-1 beta mRNA , *induced* [IL-1 beta] mRNA was adequately translated into protein . Positive_regulation IL1B SELE 14505317 1144691 We have successfully applied the assays to evaluate ( a ) *activation* of ( CD62E ) expression by [interleukin-1beta] in human umbilical vein endothelial cells ( HUVECs ) , ( b ) induction of CD3 by phorbol-12-myristate-13-acetate in freshly prepared human peripheral blood lymphocytes , and ( c ) staurosporine induced apoptosis in HUVEC and normal human dermal fibroblasts . Positive_regulation IL1B SELE 15148373 1252284 When was *induced* by [IL-1beta] , or lipopolysaccharide , human umbilical vein endothelial cells and human dermal microvascular endothelial cells each became markedly more sensitive to inhibition by endostatin in a vascular endothelial growth factor induced cell migration assay . Positive_regulation IL1B SELE 20070238 2201286 In vitro activation of Toll-like receptor 2 (TLR2) , up-regulated in ENL lesions , triggered induction of [IL-1beta] , which together with interferon gamma *induced* expression on and neutrophil adhesion to endothelial cells . Positive_regulation IL1B SELE 7523818 272285 These findings suggest that [IL-1 beta] , one of mediators in chronic sinusitis , is produced by PMNs , *induces* the expression of ICAM-1 and on endothelial cells , and , thereby , stimulates PMN infiltration in chronic sinusitis . Positive_regulation IL1B SELE 7523851 272289 Transcription of the endothelial leukocyte adhesion molecule 1 ( or ELAM-1 ) gene is *induced* by the inflammatory cytokines [interleukin-1 beta] and tumor necrosis factor alpha (TNF-alpha) . Positive_regulation IL1B SELE 9188871 437504 Whereas incubation mixtures with pro-IL-1 beta which had been incubated in the absence of SCCE , or with SCCE , which had been incubated in the absence of pro-Il-1 beta , did not induce expression above baseline levels of E-Selectin , [pro-Il1 beta] which had been incubated with SCCE *induced* a significant increase in expression . Positive_regulation IL1B SELL 7523851 272290 Transcription of the endothelial ( E-selectin or ELAM-1 ) gene is *induced* by the inflammatory cytokines [interleukin-1 beta] and tumor necrosis factor alpha (TNF-alpha) . Positive_regulation IL1B SERPINA1 9445306 483337 and protease complexation is *induced* by lipopolysaccharide , [interleukin-1beta] , and tumor necrosis factor-alpha in monocytes . Positive_regulation IL1B SERPINA3 8747137 343523 [IL-1 beta] and TNF alpha , but not IL-6 , *induce* expression in the human astrocytoma cell line U373 MG . Positive_regulation IL1B SERPINE1 10102472 602253 The *activation* of expression by [IL-1beta] is attenuated by estrogen in hepatoblastoma HepG2 cells expressing estrogen receptor alpha . Positive_regulation IL1B SERPINH1 11994473 939054 In the present study , using human embryonic lung fibroblast cells , we first disclosed that both TGF-beta and [IL-1beta] *induced* synthesis . Positive_regulation IL1B SETBP1 7665990 322106 Furthermore , ethanol treatment ( 25-100 mM ) significantly inhibited SEA- or *induced* production of tumor necrosis factor-alpha (TNF-alpha) , [interleukin-1 beta (IL-1 beta)] , and IL-6 in monocytes . Positive_regulation IL1B SETBP1 7665990 322108 Furthermore , experiments using cycloheximide indicate that de novo protein synthesis is required for the inhibitory effect of ethanol on *induced* [IL-1 beta] mRNA production . Positive_regulation IL1B SETBP1 8258334 238642 Monoclonal antibodies directed against HLA-DR and -DQ abolished the *induced* expression of both the [IL-1 beta] and TNF-alpha genes , suggesting that the HLA class II molecules mediated the gene expression . Positive_regulation IL1B SETBP1 8960643 402280 In *response* to , patients with sepsis and patient with septic shock demonstrated significantly decreased release of TNF-alpha and [IL-1beta] . Positive_regulation IL1B SETBP1 9267623 449678 Culture supernatants were assayed for cytokines IL-1 beta , IL-6 and chemotactic agents IL-8 and LTB4 *induced* the production of [IL-1 beta] and IL-8 . Positive_regulation IL1B SETD1A 10899837 712403 Recombinant *stimulated* the production of [interleukin-1beta] , interleukin-6 , and tumor necrosis factor alpha by human peripheral blood mononuclear cells . Positive_regulation IL1B SFTPC 18523246 1922692 LPC or alone *induced* the release of precursor ( pro-IL-1beta ) and mature [IL-1beta] ( mIL-1beta ) from LPS primed MG6 cells , possibly due to lytic functions . Positive_regulation IL1B SFTPC 18523246 1922693 Conversely , ATP inhibited the release of [pro-IL-1beta] and mIL-1beta *induced* by . Positive_regulation IL1B SGCG 7927746 273964 Both agents contributed to the downregulation of *induced* [IL-1 beta] and TNF-alpha gene expression . Positive_regulation IL1B SGCG 8188366 256770 Finally , our results , obtained with protein tyrosine kinase inhibitors and antiphosphotyrosine Western blotting ( immunoblotting ) , indicate that protein tyrosine kinase is involved in *induced* [IL-1 beta] and TNF-alpha gene expression in the THP-1 monocytic cell line . Positive_regulation IL1B SIRPA 12483539 1024778 A *role* for in [IL-1beta-] and TNFalpha dependent signaling . Positive_regulation IL1B SIRPA 12483539 1024781 We investigated the *role* of in [IL-1beta-] and TNFalpha dependent signaling that leads to the activation of Erk 1/2 and Akt . Positive_regulation IL1B SIRPA 12483539 1024821 Moreover , [IL-1beta-stimulation] *induced* association of with IL-1RAcP , a second subunit of IL-1 receptor , whereas expression of SHPS-1 mutant that lack SHP-2 binding function clearly blocked the association and tyrosine phosphorylation of endogenous SHPS-1 . Positive_regulation IL1B SLC33A1 14617687 1209981 These results suggest that in rats , brain ANG II and receptors are *involved* in the LPS induced production of brain [IL-1beta] , thus contributing to the fever induced by the presence of LPS within the brain . Positive_regulation IL1B SLPI 7946401 276755 In addition , we show that [interleukin-1 beta] and tumor necrosis factor *induce* significant expression and are major inducers of elafin/pre-elafin expression . Positive_regulation IL1B SMAD7 15752249 1379941 Real-time polymerase chain reaction ( PCR ) and immunohistochemistry revealed that gene transfer of *resulted* in a substantial inhibition of [interleukin-1beta (IL-1beta)] and tumor necrosis factor alpha (TNFalpha) expression ( all P < 0.01 vs. control ) . Positive_regulation IL1B SMAD7 21445336 2412249 [IL1B] *induced* negatively regulates gastrin expression . Positive_regulation IL1B SMAD7 21445336 2412252 In this study , we report that [IL1B] *induces* expression by about 4.5 fold in gastric carcinoma cell line , AGS . Positive_regulation IL1B SMC2 9235962 445563 Stimulation of vascular and EC through rCD40L *resulted* in the release of biologically active [IL-1beta] , indicating processing of the native IL-1beta precursor induced by the ligand . Positive_regulation IL1B SMC3 9235962 445567 Stimulation of vascular and EC through rCD40L *resulted* in the release of biologically active [IL-1beta] , indicating processing of the native IL-1beta precursor induced by the ligand . Positive_regulation IL1B SMC4 9235962 445564 Stimulation of vascular and EC through rCD40L *resulted* in the release of biologically active [IL-1beta] , indicating processing of the native IL-1beta precursor induced by the ligand . Positive_regulation IL1B SMC5 9235962 445565 Stimulation of vascular and EC through rCD40L *resulted* in the release of biologically active [IL-1beta] , indicating processing of the native IL-1beta precursor induced by the ligand . Positive_regulation IL1B SMC6 9235962 445566 Stimulation of vascular and EC through rCD40L *resulted* in the release of biologically active [IL-1beta] , indicating processing of the native IL-1beta precursor induced by the ligand . Positive_regulation IL1B SMPD1 19300439 2064192 ATP induced shedding and [IL-1beta] release are markedly *reduced* by the inhibition of , and completely blocked in glial cultures from acid sphingomyelinase knockout mice . Positive_regulation IL1B SMPD2 10704249 672795 *Activation* of by [IL-1beta] requires the type 1 interleukin 1 receptor . Positive_regulation IL1B SMPD2 10704249 672803 The cytokine interleukin 1beta (IL-1beta) plays an important role in host defence reactions and neuro-immune interactions but it is still not clear which of the two interleukin 1 receptor subtypes is coupled to *activation* of by [IL-1beta] . Positive_regulation IL1B SMPD2 10704249 672808 These data suggest that , a key enzyme of the sphingomyelin signal transduction pathway , might be *involved* in [IL-1beta] signalling in the brain and that activation of the enzyme requires the IL-1 receptor type 1 . Positive_regulation IL1B SNORD1A 8495422 219507 The secretions of [IL-1 beta] , TNF-alpha , and -beta , and IFN-gamma *induced* by either or F42K were markedly reduced compared with secretions produced in response to recombinant wild-type IL-2 . Positive_regulation IL1B SOAT1 16934228 1639078 In the present study , we investigated whether the activation of signaling *mediates* [IL-1beta] expression in pancreatic acinar AR42J cells stimulated with cerulein in vitro as well as the rats with cerulein pancreatitis in vivo using AG490 , the Jak2 inhibitor . Positive_regulation IL1B SOCS2 10969179 728340 In tonsillar cells , CIS expression was increased and was *induced* by [IL-1beta] , IL-6 , PRL and GH . Positive_regulation IL1B SOCS3 11014223 736329 Although [IL-1/beta] and TNFalpha alone *induced* only weakly the expression of and CIS , these cytokines strongly potentiated the induction of these two SOCS by GH . Positive_regulation IL1B SOCS3 15308667 1303467 In hepatocytes [IL-1beta] alone does not *induce* expression , but it counteracts SOCS3-promoter activation in long term studies . Positive_regulation IL1B SOCS3 15561930 1341215 We show that [IL-1beta] increases SOCS-3 expression and *induces* complex formation in RINm5F cells . Positive_regulation IL1B SOCS3 19783688 2147677 We propose that IFN-beta-1a mediated up-regulation of the expression , induced via STAT3 phosphorylation , *mediates* [IL-1beta] and IL-23 down-regulation , while IFN-beta-1a induced STAT1 phosphorylation induces IL-27p28 expression . Positive_regulation IL1B SOD1 10195945 604248 Although AT decreased superoxide release from activated monocytes , and catalase *had* no effect on [IL-1 beta] release . Positive_regulation IL1B SOD1 19561107 2104176 Not only silencing of thioredoxin , but also of the ROS scavenger *results* in inhibition of [IL-1beta] secretion . Positive_regulation IL1B SOD1 20616033 2290995 We report that ALS linked mutant *activates* caspase-1 and [IL-1beta] in microglia . Positive_regulation IL1B SOD1 20616033 2290996 Notably , mutant *induced* [IL-1beta] correlated with amyloid-like misfolding and was independent of dismutase activity . Positive_regulation IL1B SOD1 8643629 363029 down-regulation *results* in an increase in [interleukin 1beta (IL- 1beta)] production by the cells , and cell death under these conditions can be prevented by either blocking antibodies against IL-1beta or the IL-1 receptor antagonist ( IL-1Ralpha ) . Positive_regulation IL1B SOD1 8719114 343865 [Interleukin-1 beta] *induces* the expression of hsp70 , heme oxygenase and in FACS purified rat islet beta-cells , but not in alpha-cells . Positive_regulation IL1B SOD2 10195945 604249 Although AT decreased superoxide release from activated monocytes , and catalase *had* no effect on [IL-1 beta] release . Positive_regulation IL1B SOD2 8719114 343866 [Interleukin-1 beta] *induces* the expression of hsp70 , heme oxygenase and in FACS purified rat islet beta-cells , but not in alpha-cells . Positive_regulation IL1B SOD3 10195945 604250 Although AT decreased superoxide release from activated monocytes , and catalase *had* no effect on [IL-1 beta] release . Positive_regulation IL1B SOD3 8719114 343867 [Interleukin-1 beta] *induces* the expression of hsp70 , heme oxygenase and in FACS purified rat islet beta-cells , but not in alpha-cells . Positive_regulation IL1B SP1 15659225 1364823 But in primary cortical neurons , decoy and siRNA experiments indicated that the [IL-1beta] induction by S100B was *mediated* by without evidence of a role for NFkappaB . Positive_regulation IL1B SP1 18772363 1985852 The *role* of in [IL-1beta] and H. pylori mediated regulation of H , K-ATPase gene transcription . Positive_regulation IL1B SPAG11B 11297615 801648 Our data suggest that [IL-1 beta] *induces* expression of and EP4 receptors in human GL cells , and that EP2 receptor is expressed in both human and murine luteal glands . Positive_regulation IL1B SPHK1 10944534 744122 *Activation* of endogenous SK activity by tumor necrosis factor-alpha (TNFalpha) , [interleukin-1beta] , and phorbol esters in HEK293T cells was blocked by expression of this inactive ( hSK ( G82D ) ) . Positive_regulation IL1B SPHK1 15855330 1400113 Compared with basal values , [IL-1beta] and TNF-alpha *induced* increases in mRNA levels relative to 18S ribosomal RNA in INS-1 cells within 1 h ; Positive_regulation IL1B SPHK1 15855330 1400119 [IL-1beta] , but not TNF-alpha , *induced* relative mRNA expression levels within 1 h in islets , whereas SPHK2 mRNA levels were unchanged . Positive_regulation IL1B SPHK1 15855330 1400127 Thus , [IL-1beta] and TNF-alpha *induced* an early and sustained increase in activity in INS-1 cells and isolated islets , suggesting that S1P plays a role in the pathological response of pancreatic beta-cells to cytokines . Positive_regulation IL1B SPHK1 20036321 2200445 Suppression of by its inhibitor , N , N Dimethylsphingosine ( DMS ) , or siRNA *resulted* in decreased mRNA expression of TNF-alpha , [IL-1beta] , and iNOS and release of TNF-alpha and nitric oxide ( NO ) in LPS activated microglia . Positive_regulation IL1B SPHK2 10944534 744123 *Activation* of endogenous SK activity by tumor necrosis factor-alpha (TNFalpha) , [interleukin-1beta] , and phorbol esters in HEK293T cells was blocked by expression of this inactive ( hSK ( G82D ) ) . Positive_regulation IL1B SPHK2 15855330 1400120 [IL-1beta] , but not TNF-alpha , *induced* relative SPHK1a mRNA expression levels within 1 h in islets , whereas mRNA levels were unchanged . Positive_regulation IL1B SPHK2 15855330 1400128 Thus , [IL-1beta] and TNF-alpha *induced* an early and sustained increase in activity in INS-1 cells and isolated islets , suggesting that S1P plays a role in the pathological response of pancreatic beta-cells to cytokines . Positive_regulation IL1B SPI1 11823535 909325 EMSAs using THP-1 cell nuclear extracts indicated that [IL-1beta] significantly *induced* binding to its target site within the IL1B promoter that was maximal at 1 h after stimulation , correlating with the kinetics of IL-1beta induction . Positive_regulation IL1B SPI1 12061786 952911 We now show a distinct mechanism by which IE1 and IE2 mediate both weak Spi-1 independent and vigorous *dependent* [IL1B] transcription from the -59 to +12 IL1B core promoter . Positive_regulation IL1B SPI1 7799967 292485 Finally , the [IL1B] promoter , which is inactive in Spi-1-deficient HeLa cells , is *activated* in these cells by cotransfection with a expression vector . Positive_regulation IL1B SPP1 12096844 961153 In primary culture of Cbfa1-/- chondrocytes , transforming growth factor (TGF) beta1 , platelet derived growth factor ( PDGF ) , [interleukin (IL)-1beta] , and thyroid hormone ( T3 ) *induced* and MMP-13 expression . Positive_regulation IL1B SPP1 16211580 1507908 [Interleukin-1beta] *induces* expression in pulmonary fibroblasts . Positive_regulation IL1B SPP1 19076536 2024213 On the contrary , *induced* IFN-gamma , IL-4 , IL-5 , IL-13 , [IL-1beta] , and TNF-alpha production in sinonasal mucosa . Positive_regulation IL1B SPRR1B 18172072 1855837 IL1alpha , [IL1beta] , IL6 , IFNgamma , and TNFalpha *induced* expression in vitro and the local expression of IL1beta and IFNgamma was elevated in ocular tissues of patients with SS and aire-deficient mice . Positive_regulation IL1B SRC 15117678 1279474 Expression of [IL-1beta] , IL-6 , IL-8 , and COX-2 mRNA was *reduced* by 30 microM PP1 , an family tyrosine kinase inhibitor , and by 25 microM SB-203580 , a p38 MAPK inhibitor . Positive_regulation IL1B SRC 20006737 2210541 In addition , overexpression of DN *blocked* both VEGF-and [IL-1beta-stimulation] of permeability , proliferation and migration , while overexpression of CA Src overpowers the inhibitory action of PEDF on permeability , proliferation and migration . Positive_regulation IL1B SRC 20302643 2238040 Increased secretion of IL-1beta was dependent upon p38 MAP kinase activity while Abeta1-40 secretion required Src family kinase activity since the specific p38 inhibitor , SB202190 , and the family kinase inhibitor , PP2 , *attenuated* [IL-1beta] and Abeta1-40 secretion , respectively . Positive_regulation IL1B SST 10727753 678089 Although *had* no effect on lung TNF-alpha or [IL-1beta] level , it increased IL-6 . Positive_regulation IL1B SST 8982099 403802 We have found that GRP , NPY , and VIP *stimulated* the production of [IL-1 beta] in old subjects , and NPY , somatostatin and VIP in young ones . Positive_regulation IL1B ST3GAL4 10773364 686410 *induced* a low production of interleukin (IL)-2 mRNAs , a mild increase in IL-1alpha and IL-6 mRNAs production , and a dramatic increase in IFN-gamma , [IL-1beta] , TNF-alpha , IL-12 and IL-2 receptor mRNAs , which correlated with positive PLN responses . Positive_regulation IL1B ST8SIA2 12384353 998632 In Stx injected mice , azithromycin significantly suppressed *induced* TNF-alpha , [IL-1beta] , and IL-6 levels in serum and improved the outcome as assessed by survival rate . Positive_regulation IL1B STAT1 12219013 986607 The 2 groups of mice were analyzed for serum levels of interferon-gamma , tumor necrosis factor-alpha , and [interleukin-1beta] as well as *activation* of NFkappaB and , 2 proinflammatory transcription factors . Positive_regulation IL1B STAT3 12057007 984319 Overexpression of dramatically *inhibited* [IL-1beta-] or LPS+IFN-gamma mediated induction of iNOS promoter-luciferase constructs that contained the wild-type iNOS promoter or ones harbouring mutated STAT binding elements . Positive_regulation IL1B STAT3 19299019 2064072 tyrosine phosphorylation is *critical* for [interleukin 1 beta] and interleukin-6 production in response to lipopolysaccharide and live bacteria . Positive_regulation IL1B STAT3 19299019 2064075 A newly developed specific inhibitor ( stattic ) blocked LPS mediated STAT3 tyrosine phosphorylation and *led* to inhibition of LPS mediated [IL-1beta] and IL-6 production but not TNF-alpha production . Positive_regulation IL1B STAT3 19299019 2064079 These results highlight the complex *role* of in cytokine production and the key role of STAT3 tyrosine phosphorylation in [IL-1beta] and IL-6 production in response to inflammation . Positive_regulation IL1B STEAP4 19289123 2051594 Moreover , both mRNA synthesis and protein expression were *induced* by [IL-1beta] in fully differentiated human mesenchymal stem cell derived adipocytes ( hMSC-Ad ) . Positive_regulation IL1B STK10 9641167 514128 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Positive_regulation IL1B STK11 9641167 514129 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Positive_regulation IL1B STK16 9641167 514130 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Positive_regulation IL1B STK19 9641167 514131 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Positive_regulation IL1B STK24 9641167 514132 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Positive_regulation IL1B STK25 9641167 514133 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Positive_regulation IL1B STK3 9641167 514134 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Positive_regulation IL1B STK31 9641167 514135 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Positive_regulation IL1B STK33 9641167 514137 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Positive_regulation IL1B STK35 9641167 514138 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Positive_regulation IL1B STK36 9641167 514139 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Positive_regulation IL1B STK38 9641167 514141 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Positive_regulation IL1B STK39 9641167 514140 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Positive_regulation IL1B STK4 9641167 514136 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Positive_regulation IL1B STK40 9641167 514142 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Positive_regulation IL1B STS 14634131 1170915 *enhances* [IL-1beta] secretion into the cell culture supernatants , at low concentrations , while suppressing at high concentrations . Positive_regulation IL1B STS 14634131 1170922 We also show that expression of the PAAD/PYRIN family proteins pyrin or cryopyrin/PYPAF1/NALP3 individually inhibits IL-1beta secretion but that coexpression of with these proteins *results* in enhanced [IL-1beta] secretion . Positive_regulation IL1B STS 15020601 1243441 Thus , cryopyrin mediated [IL-1beta] secretion *requires* in monocytic cells . Positive_regulation IL1B STS 16407888 1527482 Cryopyrin and are *essential* for caspase-1 activation and [IL-1beta] and IL-18 production in response to bacterial RNA and the imidazoquinoline compounds R837 and R848 . Positive_regulation IL1B STS 16407890 1527495 Macrophages exposed to Gram positive Staphylococcus aureus or Listeria monocytogenes , however , *required* both and cryopyrin to activate caspase-1 and secrete [IL-1beta] . Positive_regulation IL1B STS 16547271 1537795 Distinct *roles* of TLR2 and the adaptor in [IL-1beta/IL-18] secretion in response to Listeria monocytogenes . Positive_regulation IL1B STS 16547271 1537801 Analysis of Listeria mutants revealed that cytosolic invasion was required for *dependent* [IL-1beta] secretion , consistent with a critical role for cytosolic signaling in the activation of caspase-1 . Positive_regulation IL1B STS 16547271 1537802 These results demonstrate that TLR2 and *regulate* the secretion of [IL-1beta] via distinct mechanisms in response to Listeria . Positive_regulation IL1B STS 18566365 1929598 In this study we show that , in human and mouse macrophages , alum induced secretion of [IL-1beta] , IL-18 , and IL-33 is *mediated* by the NLR ( nucleotide binding domain leucine-rich repeat containing ) protein NLRP3 and its adaptor , but not by NLRC4 . Positive_regulation IL1B STS 19587006 2111760 Using a pulmonary infection model that reflects human infection , we show that K. pneumonia induced mouse macrophage necrosis , HMGB1 , and [IL-1beta] release are *dependent* on NLRP3 and . Positive_regulation IL1B STS 20008285 2191232 RNA interference and inhibitor experiments in human PBMCs as well as experiments in Nlrp3 and Rip2 knockout bone marrow derived macrophages demonstrated that the Listeria induced [IL-1beta] release was *dependent* on , caspase-1 , and NLRP3 , whereas NOD2 , Rip2 , NLRP1 , NLRP6 , NLRP12 , NLRC4 , and AIM2 appeared to be dispensable . Positive_regulation IL1B STS 20393140 2262214 TLR2 was required for induction of pro-IL-1beta , whereas the was *required* for caspase-1 activation and pro-IL-1beta cleavage to produce mature [IL-1beta] . Positive_regulation IL1B STX1A 15102770 1239920 Compared to LPS , was a poor *inducer* of [IL-1beta] protein expression , although levels of soluble IL-1beta induced by all treatments continually increased over 72 h . IL-1beta transcripts were not induced by Stx1 B-subunits . Positive_regulation IL1B STX1A 19596774 2122941 PI3K , Akt , and mTOR inhibitors and small interfering RNA knockdown of Akt expression all increased , whereas a GSK-3alpha/beta inhibitor decreased , *induced* soluble tumor necrosis factor alpha and [interleukin-1beta] production . Positive_regulation IL1B STX1B 15102770 1239921 Compared to LPS , Stx1 was a poor inducer of IL-1beta protein expression , although levels of soluble IL-1beta induced by all treatments continually increased over 72 h . [IL-1beta] transcripts were not *induced* by . Positive_regulation IL1B STX2 11395932 823375 In contrast to TNF-alpha mRNA , anisodamine at concentrations as high as 400 micrograms/ml did not decrease *induced* [IL-1 beta] and IL-8 mRNA levels . Positive_regulation IL1B SULT1E1 9643476 514463 We found that at low concentrations *enhanced* the production of both TNF-alpha and [IL-1beta] . Positive_regulation IL1B SYK 20401456 2282155 Recent work has uncovered essential *roles* for the and the cytosolic NLRP3 inflammasome for [Interleukin-1beta (IL-1beta)] production in innate antifungal immunity . Positive_regulation IL1B SYT1 17189835 1680272 Compared to wild-type mice , the obese mice exhibited higher levels of phosphorylation of these proteins , greater *activation* of , and higher levels of circulating proinflammatory cytokines , including TNF-alpha , [IL-1beta] and IL-6 , on UVB irradiation . Positive_regulation IL1B TAB1 17348859 1733937 We also show that MDP activates ERK1 ( extracellular-signal regulated kinase 1 ) /ERK2 and p38alpha MAPK in human peripheral-blood mononuclear cells and that the activity of both MAPKs and are *required* for MDP induced signalling and production of [IL-1beta] and TNFalpha in these cells . Positive_regulation IL1B TANK 10201981 605777 In addition , our data suggest that is *involved* in [IL-1 beta] signaling in HT-29 cells . Positive_regulation IL1B TAT 15194470 1259993 In addition , 17beta-estradiol selectively inhibited the *induced* expression of [IL-1beta] . Positive_regulation IL1B TAT 20336759 2230975 Mechanism of *induction* of [interleukin-1beta] from human monocytes : Involvement of the phospholipase C/protein kinase C signaling cascade . Positive_regulation IL1B TAT 20336759 2230976 Previous reports have shown that extracellular *stimulates* [IL-1beta] expression in monocytes/macrophages . Positive_regulation IL1B TAT 20336759 2230977 The present study shows that *increases* the production of [IL-1beta] in human monocytes ; Positive_regulation IL1B TAT 20336759 2230978 PLC-PKC pathway dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in [IL-1beta] *induction* by ; Positive_regulation IL1B TAT 9378998 465791 Therefore , the mechanism by which HIV-Tat activates monocyte function is dependent on *induced* production of cytokines ( [IL-1 beta] and TNF-alpha ) . Positive_regulation IL1B TBCA 15278864 1277269 *increased* swelling ( P < .05 ) , chromodaccryorrhea ( P < .05 ) , meal duration at 24 and 48 hours , and TMJ retrodiscal tissue [interleukin-1beta] ( P < 0.01 ) in group 3 , but treatment with the COX-2-I attenuated these effects in group 4 , ( CFA + COX-2-I ) . Positive_regulation IL1B TBCA 17689191 1873853 IL-1ra was given ( i.t. ) 24h before CFA to block the action of basal IL-1beta and 2h prior to each of two PWL tests to block *induced* [IL-1beta] . Positive_regulation IL1B TBCA 18721668 1955881 ( 3 ) Repeated EA stimulation of ipsilateral ` Huan-Tiao ' ( GB30 ) and ` Yang-Ling-Quan ' ( GB34 ) acupoints significantly suppressed CFA induced hyperalgesia , and markedly inhibited the *induced* increase of the level of PGE ( 2 ) as well as [IL-1beta] , IL-6 , and TNF-alpha in the spinal cord ; Positive_regulation IL1B TBCA 9651226 515488 Conversely , local injection of low doses of recombinant LIF diminishes mechanical and thermal hypersensitivity as well as the [IL-1beta] and NGF expression *induced* by . Positive_regulation IL1B TCF12 8798568 381659 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by [interleukin-1beta] plus tumor necrosis factor-alpha , and its full induction *requires* the presence of the , c-FOS . Positive_regulation IL1B TCF15 8798568 381660 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by [interleukin-1beta] plus tumor necrosis factor-alpha , and its full induction *requires* the presence of the , c-FOS . Positive_regulation IL1B TCF19 8798568 381661 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by [interleukin-1beta] plus tumor necrosis factor-alpha , and its full induction *requires* the presence of the , c-FOS . Positive_regulation IL1B TCF20 8798568 381662 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by [interleukin-1beta] plus tumor necrosis factor-alpha , and its full induction *requires* the presence of the , c-FOS . Positive_regulation IL1B TCF21 8798568 381663 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by [interleukin-1beta] plus tumor necrosis factor-alpha , and its full induction *requires* the presence of the , c-FOS . Positive_regulation IL1B TCF23 8798568 381667 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by [interleukin-1beta] plus tumor necrosis factor-alpha , and its full induction *requires* the presence of the , c-FOS . Positive_regulation IL1B TCF24 8798568 381669 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by [interleukin-1beta] plus tumor necrosis factor-alpha , and its full induction *requires* the presence of the , c-FOS . Positive_regulation IL1B TCF25 8798568 381668 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by [interleukin-1beta] plus tumor necrosis factor-alpha , and its full induction *requires* the presence of the , c-FOS . Positive_regulation IL1B TCF3 8798568 381664 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by [interleukin-1beta] plus tumor necrosis factor-alpha , and its full induction *requires* the presence of the , c-FOS . Positive_regulation IL1B TCF4 8798568 381665 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by [interleukin-1beta] plus tumor necrosis factor-alpha , and its full induction *requires* the presence of the , c-FOS . Positive_regulation IL1B TCF7 8798568 381666 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by [interleukin-1beta] plus tumor necrosis factor-alpha , and its full induction *requires* the presence of the , c-FOS . Positive_regulation IL1B TEC 19393603 2082055 Furthermore , LPS induced actin polymerization as well as MCP-1 , tumor necrosis factor-alpha , interleukin-6 , and [interleukin-1beta] expression are *dependent* on kinase activity . Positive_regulation IL1B TERT 12732209 1087104 *upregulates* expression levels of interleukin (IL)-1alpha , [IL-1beta] , IL-6 , IL-8 , and granulocyte-macrophage colony stimulating factor in normal human fibroblasts . Positive_regulation IL1B TGFB1 10433158 633935 However , TNFalpha induced increase in TGFbeta1 mRNA expression was not translated intoTGFbeta1 protein secretion , while [IL-1beta] stimulation *induced* a significant increase in TGFbeta1 protein secretion as well as mRNA expression . Positive_regulation IL1B TGFB1 14749204 1242763 Although both IL-1beta and enhance glucose transport in chondrocytes to a similar magnitude , [IL-1beta] *induces* significantly higher levels of lactate . Positive_regulation IL1B TGFB1 15336943 1291310 [Interleukin-1beta] *induces* a predominantly pro-inflammatory profile while can be linked to proliferative and matrix changes . Positive_regulation IL1B TGFB1 16211580 1507914 Our results demonstrate a potent and dramatic increase in osteopontin expression *induced* by [interleukin-1beta (IL-1beta)] , whereas tumor necrosis factor-alpha , , and angiotensin II had minimal effect . Positive_regulation IL1B TGFB1 16226884 1483583 However HAS2 transcription increased 10-fold in *response* to and [IL-1beta] . Positive_regulation IL1B TGFB1 1717497 166799 the production by leukemic cells of [IL-1 beta] and TNF-alpha was significantly *promoted* by . Positive_regulation IL1B TGFB1 18163503 1855445 Human articular chondrocytes were treated with [IL-1beta] in the *presence* of , pyrrolidine dithiocarbamate ( a repressor of the NF-kappaB pathway ) , or cycloheximide . Positive_regulation IL1B TGFB1 19278421 2046321 treatment , which augmented E-cadherin and down-regulated dendritic cell-specific ICAM3 grabbing non-integrin on MoDCs , significantly suppressed their CD86 expression and hapten *induced* expression of [IL-1beta] and TNF-alpha mRNA and protein . Positive_regulation IL1B TGFB1 2240083 144732 On the basis of these findings , we suggest that the increase in decidual [interleukin-1 beta] and human leukocyte antigen HLA-DR alpha during pregnancy may be involved in maternal recognition of the fetal semiallograft and that production may *regulate* the local maternal immune response and prevent rejection of the fetus . Positive_regulation IL1B TGFB1 7980594 281362 [Interleukin-1 beta (IL-1 beta)] *induces* , ( TGF-beta 1 ) production by rat aortic smooth muscle cells . Positive_regulation IL1B TGFB1 8135772 251758 In the cell line CAKI-2 , [interleukin 1 beta] , Platelet derived growth factor BB and all *increased* mRNA splice variants where the CS1 and CS5 regions were removed . Positive_regulation IL1B TGFB1 8408003 233209 IL-11 mRNA was induced in chondrocytes in *response* to and [IL-1 beta] . Positive_regulation IL1B TGFB1 8889469 391654 did not affect IL-1 beta mRNA levels but *caused* variable increases in [IL-1 beta] protein levels . Positive_regulation IL1B TGFB1 9186223 436773 Titanium , cobalt , and chromium at concentrations ranging from 0.01 to 100 ng/ml significantly *enhanced* the release of [interleukin-1 beta] and tumor necrosis factor-alpha by lipopolysaccharide stimulated human osteogenic sarcoma cells , whereas they did not alter the release of . Positive_regulation IL1B TGFB2 11519483 851887 We hypothesized that [IL1-beta] , IL6 , transforming growth factor ( and platelet activating factor could *increase* macrophage QUIN production . Positive_regulation IL1B TGFB2 16211580 1507915 Our results demonstrate a potent and dramatic increase in osteopontin expression *induced* by [interleukin-1beta (IL-1beta)] , whereas tumor necrosis factor-alpha , , and angiotensin II had minimal effect . Positive_regulation IL1B TGFB2 2240083 144733 On the basis of these findings , we suggest that the increase in decidual [interleukin-1 beta] and human leukocyte antigen HLA-DR alpha during pregnancy may be involved in maternal recognition of the fetal semiallograft and that production may *regulate* the local maternal immune response and prevent rejection of the fetus . Positive_regulation IL1B TGFB2 7980594 281363 [Interleukin-1 beta (IL-1 beta)] *induces* , ( TGF-beta 1 ) production by rat aortic smooth muscle cells . Positive_regulation IL1B TGFB2 9704780 525623 In the medium containing lipopolysaccharide plus transforming growth factor-beta2 , also decreased the lipopolysaccharide induced prostaglandin E2 production significantly at the concentrations of 1 ng/mL and 10 ng/mL ( P < .05 ) but *increased* the lipopolysaccharide induced [interleukin-1beta] production significantly at the concentration of 1 ng/mL ( P < .05 ) . Positive_regulation IL1B TGFB3 16211580 1507916 Our results demonstrate a potent and dramatic increase in osteopontin expression *induced* by [interleukin-1beta (IL-1beta)] , whereas tumor necrosis factor-alpha , , and angiotensin II had minimal effect . Positive_regulation IL1B TGFB3 2240083 144734 On the basis of these findings , we suggest that the increase in decidual [interleukin-1 beta] and human leukocyte antigen HLA-DR alpha during pregnancy may be involved in maternal recognition of the fetal semiallograft and that production may *regulate* the local maternal immune response and prevent rejection of the fetus . Positive_regulation IL1B TGFB3 7980594 281364 [Interleukin-1 beta (IL-1 beta)] *induces* , ( TGF-beta 1 ) production by rat aortic smooth muscle cells . Positive_regulation IL1B TGFB3 8376781 229966 [IL-1 beta] selectively *induced* protein synthesis but reduced synthesis of the TGF-beta 1 and TGF-beta 2 isoforms . Positive_regulation IL1B TGM4 2787383 114843 In this study we show that *induces* human PBL and adherent cells to produce IL-1 alpha and [IL-1 beta] . Positive_regulation IL1B TH 19309436 2073461 Moreover , [IL-1beta] regulates catecholamine synthesis as the inhibition of tyrosine hydroxylase decreases IL-1beta evoked catecholamine release and the cytokine *induces* Ser40 phosphorylation . Positive_regulation IL1B TH 19544469 2128850 We showed that [IL-1beta] *induced* a rapid induction of mRNA of dopaminergic key fate determining transcription factors , such as Nurr1 and Pitx3 , and a subsequent increase of protein as an early marker for dopaminergic neurons in vitro . Positive_regulation IL1B TIMP1 18577571 1930285 Thus , [IL-1 beta] *induced* secretion in a dose dependent manner with maximal 3.5-fold upregulation seen at 0.67 ng/ml IL-1 beta relative to untreated cells . Positive_regulation IL1B TIMP1 8898888 393143 We found that transforming growth factor beta 1 as well as [interleukin-1 beta] *induce* gene expression of both and TIMP-3 . Positive_regulation IL1B TIMP1 9821179 548091 The inflammatory cytokine [interleukin-1 beta (IL-1 beta)] did not *induce* MMP or expression . Positive_regulation IL1B TIMP3 8898888 393144 We found that transforming growth factor beta 1 as well as [interleukin-1 beta] *induce* gene expression of both TIMP-1 and . Positive_regulation IL1B TLR1 17404311 1722006 Alum induced [IL-1beta] and IL-18 production was not *due* to enhancement of signaling but rather reflected caspase-1 activation and in mouse dendritic cells occurred in a MyD88 independent fashion . Positive_regulation IL1B TLR1 17459804 1731510 Secretion of the proinflammatory cytokine [IL-1beta] *requires* caspase-1 and signaling . Positive_regulation IL1B TLR1 17467812 1737413 stimulation of RA-FLS also *induced* the production of [IL-1beta] and TNF-alpha to a lesser extent ; Positive_regulation IL1B TLR1 17652449 1793654 *induced* TNF-alpha , [IL-1beta] , and IL-10 production is mediated through MyD88 , whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta . Positive_regulation IL1B TLR1 18990074 1983827 Monocytes can release active [IL-1 beta] upon *stimulation* with ligands alone . Positive_regulation IL1B TLR1 19249118 2105975 Determination of expression-levels using real-time RT-PCR showed significantly augmented *dependent* [IL-1beta] and caspase-1 expression . Positive_regulation IL1B TLR1 19544485 2103835 In contrast , TLR4 , TLR9 and receptors are not *involved* in [IL-1beta] induction . Positive_regulation IL1B TLR1 20200276 2229586 Caspase-1 independent [IL-1beta] production is critical for host resistance to mycobacterium tuberculosis and does not *require* signaling in vivo . Positive_regulation IL1B TLR1 20495003 2289001 *induced* [IL-1beta] production and release were investigated for dependence upon caspase-1 , P2X7 receptor activation , and loss of membrane asymmetry associated with microvesicle shedding . Positive_regulation IL1B TLR10 17404311 1722014 Alum induced [IL-1beta] and IL-18 production was not *due* to enhancement of signaling but rather reflected caspase-1 activation and in mouse dendritic cells occurred in a MyD88 independent fashion . Positive_regulation IL1B TLR10 17459804 1731519 Secretion of the proinflammatory cytokine [IL-1beta] *requires* caspase-1 and signaling . Positive_regulation IL1B TLR10 17467812 1737421 stimulation of RA-FLS also *induced* the production of [IL-1beta] and TNF-alpha to a lesser extent ; Positive_regulation IL1B TLR10 17652449 1793662 *induced* TNF-alpha , [IL-1beta] , and IL-10 production is mediated through MyD88 , whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta . Positive_regulation IL1B TLR10 18990074 1983835 Monocytes can release active [IL-1 beta] upon *stimulation* with ligands alone . Positive_regulation IL1B TLR10 19249118 2105983 Determination of expression-levels using real-time RT-PCR showed significantly augmented *dependent* [IL-1beta] and caspase-1 expression . Positive_regulation IL1B TLR10 20200276 2229594 Caspase-1 independent [IL-1beta] production is critical for host resistance to mycobacterium tuberculosis and does not *require* signaling in vivo . Positive_regulation IL1B TLR10 20495003 2289009 *induced* [IL-1beta] production and release were investigated for dependence upon caspase-1 , P2X7 receptor activation , and loss of membrane asymmetry associated with microvesicle shedding . Positive_regulation IL1B TLR2 12691617 1080370 LPS-TLR4 adapted human THP-1 promonocytic cells cross-adapt to lipoteichoic acid <(LTA)-TLR2> *induced* [IL-1beta/TNF-alpha] production , suggesting disruption of a common intracellular signaling event ( s ) . Positive_regulation IL1B TLR2 16547271 1537796 Distinct *roles* of and the adaptor ASC in [IL-1beta/IL-18] secretion in response to Listeria monocytogenes . Positive_regulation IL1B TLR2 16982856 1617233 Using short hairpin RNA , we demonstrate an essential role for ASC in *induction* of [IL-1beta] by , 4 , and 5 agonists , live Escherichia coli , and Pg. Induction of IL-6 , IL-8 , IL-10 , and TNF also requires ASC , but this induction is not inhibited by IL-1 receptor antagonist or caspase-1 inhibitor . Positive_regulation IL1B TLR2 17404311 1722007 Alum induced [IL-1beta] and IL-18 production was not *due* to enhancement of signaling but rather reflected caspase-1 activation and in mouse dendritic cells occurred in a MyD88 independent fashion . Positive_regulation IL1B TLR2 17459804 1731511 Secretion of the proinflammatory cytokine [IL-1beta] *requires* caspase-1 and signaling . Positive_regulation IL1B TLR2 17467812 1737414 stimulation of RA-FLS also *induced* the production of [IL-1beta] and TNF-alpha to a lesser extent ; Positive_regulation IL1B TLR2 17652449 1793655 *induced* TNF-alpha , [IL-1beta] , and IL-10 production is mediated through MyD88 , whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta . Positive_regulation IL1B TLR2 18773284 2028350 Combined and NOD2 stimulation *induced* a four-fold higher secretion of TNFalpha and a 13-fold higher secretion of [IL-1 beta] in patients . Positive_regulation IL1B TLR2 18990074 1983828 Monocytes can release active [IL-1 beta] upon *stimulation* with ligands alone . Positive_regulation IL1B TLR2 19249118 2105976 Determination of expression-levels using real-time RT-PCR showed significantly augmented *dependent* [IL-1beta] and caspase-1 expression . Positive_regulation IL1B TLR2 19250704 2182419 These data indicate that LTA dependent activation in odontoblasts and pulp fibroblasts , in contrast to immature DCs , does not *lead* to significant TNF-alpha and [IL-1beta] production , but that all three cell types influence the pulp inflammatory/immune response through CXCL8 synthesis and secretion . Positive_regulation IL1B TLR2 19474209 2085600 Aspergillus fumigatus keratitis developed in Wistar rats , as evidenced by high SLE scores , influx of polymorphonuclear leukocytes ( PMNs ) , *activation* of and TLR4 , and production of [IL-1beta] and IL-10 over controls . Positive_regulation IL1B TLR2 19503839 2091974 activation *triggered* [IL-1beta] activity , involving the upregulation of both IL-1beta and IL-1 receptor , and downregulation of the IL-1 receptor antagonist . Positive_regulation IL1B TLR2 19503839 2091977 *induction* of [IL-1beta] was required for upregulation of DEFB4 , but not cathelicidin , whereas VDR activation was required for expression of both antimicrobial genes . Positive_regulation IL1B TLR2 19819943 2164534 FFA induced [IL-1beta] and KC expression in mouse islets was completely dependent on the IL-1R/Toll-like receptor (TLR) docking protein Myd88 and partly *dependent* on and -4 . Positive_regulation IL1B TLR2 20200276 2229587 Caspase-1 independent [IL-1beta] production is critical for host resistance to mycobacterium tuberculosis and does not *require* signaling in vivo . Positive_regulation IL1B TLR2 20393140 2262215 was *required* for induction of [pro-IL-1beta] , whereas the NLRP3/ASC was required for caspase-1 activation and pro-IL-1beta cleavage to produce mature IL-1beta . Positive_regulation IL1B TLR2 20495003 2289002 *induced* [IL-1beta] production and release were investigated for dependence upon caspase-1 , P2X7 receptor activation , and loss of membrane asymmetry associated with microvesicle shedding . Positive_regulation IL1B TLR3 17404311 1722008 Alum induced [IL-1beta] and IL-18 production was not *due* to enhancement of signaling but rather reflected caspase-1 activation and in mouse dendritic cells occurred in a MyD88 independent fashion . Positive_regulation IL1B TLR3 17459804 1731512 Secretion of the proinflammatory cytokine [IL-1beta] *requires* caspase-1 and signaling . Positive_regulation IL1B TLR3 17467812 1737415 stimulation of RA-FLS also *induced* the production of [IL-1beta] and TNF-alpha to a lesser extent ; Positive_regulation IL1B TLR3 17652449 1793656 *induced* TNF-alpha , [IL-1beta] , and IL-10 production is mediated through MyD88 , whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta . Positive_regulation IL1B TLR3 18725521 1955977 These results implicate a novel role for caspase-8 in the production of biologically active [IL-1beta] in *response* to and TLR4 stimulation . Positive_regulation IL1B TLR3 18990074 1983829 Monocytes can release active [IL-1 beta] upon *stimulation* with ligands alone . Positive_regulation IL1B TLR3 19249118 2105977 Determination of expression-levels using real-time RT-PCR showed significantly augmented *dependent* [IL-1beta] and caspase-1 expression . Positive_regulation IL1B TLR3 20200276 2229588 Caspase-1 independent [IL-1beta] production is critical for host resistance to mycobacterium tuberculosis and does not *require* signaling in vivo . Positive_regulation IL1B TLR3 20495003 2289003 *induced* [IL-1beta] production and release were investigated for dependence upon caspase-1 , P2X7 receptor activation , and loss of membrane asymmetry associated with microvesicle shedding . Positive_regulation IL1B TLR4 12874240 1114984 Using an in vivo injury model , we demonstrate that injury significantly increased TLR2- and *induced* [IL-1beta] , IL-6 , and TNF-alpha production by spleen cells . Positive_regulation IL1B TLR4 16622195 1551603 Functional is *essential* for an efficient [IL-1-beta] , TNF-alpha , and IFN-gamma response ; Positive_regulation IL1B TLR4 17404311 1722009 Alum induced [IL-1beta] and IL-18 production was not *due* to enhancement of signaling but rather reflected caspase-1 activation and in mouse dendritic cells occurred in a MyD88 independent fashion . Positive_regulation IL1B TLR4 17442978 1729727 In addition , PI3K inhibition resulted in strongly elevated *mediated* generation of [IL-1beta] and IL-8 in neutrophils when these cells were co-stimulated with C5a . Positive_regulation IL1B TLR4 17459804 1731513 Secretion of the proinflammatory cytokine [IL-1beta] *requires* caspase-1 and signaling . Positive_regulation IL1B TLR4 17467812 1737416 stimulation of RA-FLS also *induced* the production of [IL-1beta] and TNF-alpha to a lesser extent ; Positive_regulation IL1B TLR4 17530716 1751472 [IL-1beta] mRNA expression was *increased* by activation , whereas expression of aggrecan and type II collagen was significantly decreased . Positive_regulation IL1B TLR4 17652449 1793657 *induced* TNF-alpha , [IL-1beta] , and IL-10 production is mediated through MyD88 , whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta . Positive_regulation IL1B TLR4 18442564 1900518 signaling *mediates* the production of TNF-alpha and [IL-1beta] peptides , and these two cytokines link TLR4 signaling to postischemic cardiac dysfunction . Positive_regulation IL1B TLR4 18725521 1955978 These results implicate a novel role for caspase-8 in the production of biologically active [IL-1beta] in *response* to TLR3 and stimulation . Positive_regulation IL1B TLR4 18990074 1983830 Monocytes can release active [IL-1 beta] upon *stimulation* with ligands alone . Positive_regulation IL1B TLR4 19028791 2022898 FXR activation by natural and synthetic ligands in these cell types attenuated [IL-1beta] , IL-6 , and TNF-alpha gene induction in *response* to activation by LPS . Positive_regulation IL1B TLR4 19249118 2105978 Determination of expression-levels using real-time RT-PCR showed significantly augmented *dependent* [IL-1beta] and caspase-1 expression . Positive_regulation IL1B TLR4 19474209 2085601 Aspergillus fumigatus keratitis developed in Wistar rats , as evidenced by high SLE scores , influx of polymorphonuclear leukocytes ( PMNs ) , *activation* of TLR2 and , and production of [IL-1beta] and IL-10 over controls . Positive_regulation IL1B TLR4 19689736 2126548 TLR4 induced [IL-1beta] production by monocytes was *increased* by dependent endothelial activation in coculture , and was associated with increased monocyte CD14 expression . Positive_regulation IL1B TLR4 19735705 2163206 This study used RNA interference techniques to show that can *mediate* LPS induced macrophage activations of [IL-1beta] and IL-6 gene expression , chemotaxis , phagocytosis , and oxidative ability . Positive_regulation IL1B TLR4 20181058 2222747 [IL-1beta] potently induced NF-kappaB activation in CaCo-2 cells , but did not *induce* expression . Positive_regulation IL1B TLR4 20200276 2229589 Caspase-1 independent [IL-1beta] production is critical for host resistance to mycobacterium tuberculosis and does not *require* signaling in vivo . Positive_regulation IL1B TLR4 20495003 2289004 *induced* [IL-1beta] production and release were investigated for dependence upon caspase-1 , P2X7 receptor activation , and loss of membrane asymmetry associated with microvesicle shedding . Positive_regulation IL1B TLR4 24657625 2938541 In macrophages and monocytes , increasing concentrations of lactate reduced *mediated* induction of [Il1B] , Nlrp3 , and Casp1 ; Positive_regulation IL1B TLR5 17404311 1722010 Alum induced [IL-1beta] and IL-18 production was not *due* to enhancement of signaling but rather reflected caspase-1 activation and in mouse dendritic cells occurred in a MyD88 independent fashion . Positive_regulation IL1B TLR5 17459804 1731514 Secretion of the proinflammatory cytokine [IL-1beta] *requires* caspase-1 and signaling . Positive_regulation IL1B TLR5 17467812 1737417 stimulation of RA-FLS also *induced* the production of [IL-1beta] and TNF-alpha to a lesser extent ; Positive_regulation IL1B TLR5 17652449 1793658 *induced* TNF-alpha , [IL-1beta] , and IL-10 production is mediated through MyD88 , whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta . Positive_regulation IL1B TLR5 18990074 1983831 Monocytes can release active [IL-1 beta] upon *stimulation* with ligands alone . Positive_regulation IL1B TLR5 19249118 2105979 Determination of expression-levels using real-time RT-PCR showed significantly augmented *dependent* [IL-1beta] and caspase-1 expression . Positive_regulation IL1B TLR5 20200276 2229590 Caspase-1 independent [IL-1beta] production is critical for host resistance to mycobacterium tuberculosis and does not *require* signaling in vivo . Positive_regulation IL1B TLR5 20495003 2289005 *induced* [IL-1beta] production and release were investigated for dependence upon caspase-1 , P2X7 receptor activation , and loss of membrane asymmetry associated with microvesicle shedding . Positive_regulation IL1B TLR6 17404311 1722015 Alum induced [IL-1beta] and IL-18 production was not *due* to enhancement of signaling but rather reflected caspase-1 activation and in mouse dendritic cells occurred in a MyD88 independent fashion . Positive_regulation IL1B TLR6 17459804 1731520 Secretion of the proinflammatory cytokine [IL-1beta] *requires* caspase-1 and signaling . Positive_regulation IL1B TLR6 17467812 1737422 stimulation of RA-FLS also *induced* the production of [IL-1beta] and TNF-alpha to a lesser extent ; Positive_regulation IL1B TLR6 17652449 1793663 *induced* TNF-alpha , [IL-1beta] , and IL-10 production is mediated through MyD88 , whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta . Positive_regulation IL1B TLR6 18990074 1983836 Monocytes can release active [IL-1 beta] upon *stimulation* with ligands alone . Positive_regulation IL1B TLR6 19249118 2105984 Determination of expression-levels using real-time RT-PCR showed significantly augmented *dependent* [IL-1beta] and caspase-1 expression . Positive_regulation IL1B TLR6 19428561 2077085 These data show that TLR2 , TLR4 , and ligation synergistically *stimulates* the production of TNF-alpha and [IL-1beta] in IL-1Ra-deficient mice and suggest that TLRs contribute to the perpetuation of spontaneous arthritis in this animal model . Positive_regulation IL1B TLR6 20200276 2229595 Caspase-1 independent [IL-1beta] production is critical for host resistance to mycobacterium tuberculosis and does not *require* signaling in vivo . Positive_regulation IL1B TLR6 20495003 2289010 *induced* [IL-1beta] production and release were investigated for dependence upon caspase-1 , P2X7 receptor activation , and loss of membrane asymmetry associated with microvesicle shedding . Positive_regulation IL1B TLR7 17404311 1722011 Alum induced [IL-1beta] and IL-18 production was not *due* to enhancement of signaling but rather reflected caspase-1 activation and in mouse dendritic cells occurred in a MyD88 independent fashion . Positive_regulation IL1B TLR7 17459804 1731516 Secretion of the proinflammatory cytokine [IL-1beta] *requires* caspase-1 and signaling . Positive_regulation IL1B TLR7 17467812 1737418 stimulation of RA-FLS also *induced* the production of [IL-1beta] and TNF-alpha to a lesser extent ; Positive_regulation IL1B TLR7 17652449 1793659 *induced* TNF-alpha , [IL-1beta] , and IL-10 production is mediated through MyD88 , whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta . Positive_regulation IL1B TLR7 18990074 1983832 Monocytes can release active [IL-1 beta] upon *stimulation* with ligands alone . Positive_regulation IL1B TLR7 19249118 2105980 Determination of expression-levels using real-time RT-PCR showed significantly augmented *dependent* [IL-1beta] and caspase-1 expression . Positive_regulation IL1B TLR7 20200276 2229591 Caspase-1 independent [IL-1beta] production is critical for host resistance to mycobacterium tuberculosis and does not *require* signaling in vivo . Positive_regulation IL1B TLR7 20495003 2289006 *induced* [IL-1beta] production and release were investigated for dependence upon caspase-1 , P2X7 receptor activation , and loss of membrane asymmetry associated with microvesicle shedding . Positive_regulation IL1B TLR8 17404311 1722012 Alum induced [IL-1beta] and IL-18 production was not *due* to enhancement of signaling but rather reflected caspase-1 activation and in mouse dendritic cells occurred in a MyD88 independent fashion . Positive_regulation IL1B TLR8 17459804 1731517 Secretion of the proinflammatory cytokine [IL-1beta] *requires* caspase-1 and signaling . Positive_regulation IL1B TLR8 17467812 1737419 stimulation of RA-FLS also *induced* the production of [IL-1beta] and TNF-alpha to a lesser extent ; Positive_regulation IL1B TLR8 17652449 1793660 *induced* TNF-alpha , [IL-1beta] , and IL-10 production is mediated through MyD88 , whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta . Positive_regulation IL1B TLR8 18990074 1983833 Monocytes can release active [IL-1 beta] upon *stimulation* with ligands alone . Positive_regulation IL1B TLR8 19249118 2105981 Determination of expression-levels using real-time RT-PCR showed significantly augmented *dependent* [IL-1beta] and caspase-1 expression . Positive_regulation IL1B TLR8 20200276 2229592 Caspase-1 independent [IL-1beta] production is critical for host resistance to mycobacterium tuberculosis and does not *require* signaling in vivo . Positive_regulation IL1B TLR8 20495003 2289007 *induced* [IL-1beta] production and release were investigated for dependence upon caspase-1 , P2X7 receptor activation , and loss of membrane asymmetry associated with microvesicle shedding . Positive_regulation IL1B TLR9 17404311 1722013 Alum induced [IL-1beta] and IL-18 production was not *due* to enhancement of signaling but rather reflected caspase-1 activation and in mouse dendritic cells occurred in a MyD88 independent fashion . Positive_regulation IL1B TLR9 17459804 1731518 Secretion of the proinflammatory cytokine [IL-1beta] *requires* caspase-1 and signaling . Positive_regulation IL1B TLR9 17467812 1737420 stimulation of RA-FLS also *induced* the production of [IL-1beta] and TNF-alpha to a lesser extent ; Positive_regulation IL1B TLR9 17652449 1793661 *induced* TNF-alpha , [IL-1beta] , and IL-10 production is mediated through MyD88 , whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta . Positive_regulation IL1B TLR9 18990074 1983834 Monocytes can release active [IL-1 beta] upon *stimulation* with ligands alone . Positive_regulation IL1B TLR9 19249118 2105982 Determination of expression-levels using real-time RT-PCR showed significantly augmented *dependent* [IL-1beta] and caspase-1 expression . Positive_regulation IL1B TLR9 19401392 2114620 We found that stimulation with CpG ODN *induces* [IL-1beta] , TNF-alpha , IL-10 , and IL-6 production . Positive_regulation IL1B TLR9 19544485 2103836 In contrast , TLR4 , and TLR1 receptors are not *involved* in [IL-1beta] induction . Positive_regulation IL1B TLR9 20200276 2229593 Caspase-1 independent [IL-1beta] production is critical for host resistance to mycobacterium tuberculosis and does not *require* signaling in vivo . Positive_regulation IL1B TLR9 20347818 2281739 In a mouse model of NASH , signaling *induces* production of [IL-1beta] by Kupffer cells , leading to steatosis , inflammation , and fibrosis . Positive_regulation IL1B TLR9 20495003 2289008 *induced* [IL-1beta] production and release were investigated for dependence upon caspase-1 , P2X7 receptor activation , and loss of membrane asymmetry associated with microvesicle shedding . Positive_regulation IL1B TNF 10377187 623617 At concentrations as low as 1-10 nM , the LXA4 and ATL analogues each inhibited *stimulated* superoxide anion generation and [IL-1beta] release by human polymorphonuclear leukocytes . Positive_regulation IL1B TNF 10377187 623618 *induced* [IL-1beta] gene expression was also regulated by both anti-LXA4 receptor antibodies and LXA4-ATL analogues . Positive_regulation IL1B TNF 10452106 637582 SMT inhibited LPS induced nitric oxide release and *increased* [IL-1 beta] and IL-6 secretions in AM , but the levels remained unchanged . Positive_regulation IL1B TNF 10469279 641082 In addition , IL-17 increased *induced* IL-1alpha , [IL-1beta] , and IL-6 mRNA expression in fetal mouse metatarsals and IL-1alpha and IL-6 mRNA expression in MC3T3-E1 cells . Positive_regulation IL1B TNF 10548204 564847 Unstimulated HUVECs did not produce detectable amounts of TNF-alpha , but IFN-gamma , [IL-1beta] , and LPS when added together *induced* production of HUVECs in a time dependent manner . Positive_regulation IL1B TNF 10548204 564851 IFN-gamma , [IL-1beta] , or LPS alone did not *induce* production , whereas IFN-gamma and IL-1beta in combination were able to induce TNF-alpha production to some extent , and the production could be further increased with LPS . Positive_regulation IL1B TNF 10564140 567133 The experiments demonstrate that LPS , TNF-alpha , [IL-1beta] , and IL-6 *induce* lowering of P ( if ) when given intravenously or intra-arterially , whereas only , IL-1beta , and IL-6 induce lowering of P ( if ) when given subdermally . Positive_regulation IL1B TNF 10685363 578865 At nanomolar levels , the LXA4 and ATL analog 15 R/S-methyl-LXA4 each blocked *stimulated* [IL-1 beta] release by isolated human PMN in vitro . Positive_regulation IL1B TNF 10685363 578866 The *induced* [IL-1 beta] gene expression was also regulated by 15 R/S-methyl-LXA4 . Positive_regulation IL1B TNF 10718111 579353 A rapid increase in PGHS-2 ( but not PGHS-1 ) mRNA expression was observed in *response* to and [IL-1beta] . Positive_regulation IL1B TNF 10843739 700316 In contrast with MO , purified LY and non fractionated PBMC expressed IL-8 in *response* to exogenous , similar to exogenous IL-1alpha and [IL-1beta] . Positive_regulation IL1B TNF 10857767 704541 In conclusion the pro-inflammatory molecule *stimulates* bone marrow stromal cell associated [IL-1beta] levels while the anti-inflammatory cytokine IL-4 reduces the TNF-alpha induced effect . Positive_regulation IL1B TNF 11034223 740625 Pulmonary interleukin (IL)-6 , [IL-1beta] , and levels *increased* significantly postinfection . Positive_regulation IL1B TNF 11115778 757916 In reaggregate cultures of rat anterior pituitaries [IL-1 beta] stimulated D1 and D2 dose-dependently and D2 activity was *increased* by . Positive_regulation IL1B TNF 11159885 781413 Spontaneous and *stimulated* interleukin (IL)-8 and [IL-1 beta] secretion and mRNA expression were assessed in HT-29 and Caco-2 intestinal epithelial cell lines in the presence of a panel of heparin and heparan sulfate disaccharides . Positive_regulation IL1B TNF 11238627 790808 Likewise , SB203580 partially prevented the up-regulation of IL-1alpha , [IL-1beta] , IL-lRa , and TNF-alpha mRNA upon *stimulation* with LPS and , as well as the release of bioactive TNF-alpha induced by LPS . Positive_regulation IL1B TNF 11241162 791937 Lipopolysaccharide , [interleukin (IL)-1beta] , and IL-6 all significantly *increased* the expression of PBEF in 4 h of treatment . Positive_regulation IL1B TNF 11243098 408408 The results were : 1. expression of TNF alpha , IL-1 beta , IL-6 mRNA in vital organs successively increased after hemorrhagic shock and resuscitation , and expression was the first to appear *followed* by [IL-1 beta] . Positive_regulation IL1B TNF 11340302 812465 Of importance , NFkappaB , but not scrambled decoy ODN , significantly attenuated the increase in RNA and protein levels of IL-1alpha , [IL-1beta] , IL-6 , ICAM-1 and VCAM-1 *induced* by assessed by RT-PCR . Positive_regulation IL1B TNF 11397893 823858 Dexamethasone inhibits *induced* apoptosis and [interleukin-1 beta] release in human subcutaneous adipocytes and preadipocytes . Positive_regulation IL1B TNF 11592383 869692 IL-17 ( 10 ng/ml ) stimulated the expression of IL-6 mRNA by 1.3-fold , while ( 1 ng/ml ) increased it by 3.7-fold , and [IL-1beta] ( 0.1 ng/ml ) *increased* it by > 30-fold . Positive_regulation IL1B TNF 11726403 884403 These pro-asthmatic- like changes in ASM responsiveness were associated with [IL-1beta/] *induced* mRNA expression of a host of proinflammatory genes that regulate transcription , cytokines and chemokines , cellular adhesion molecules , and various signal transduction molecules that regulate ASM responsiveness . Positive_regulation IL1B TNF 11750868 889868 The pathogenic microorganisms *induced* a dose- and time dependent release of [IL-1beta] , IL-6 , IL-8 , and IL-10 , whereas secretion was not elevated . Positive_regulation IL1B TNF 11786084 901239 BMP-7 represses the basal and *stimulated* expression of the pro-inflammatory cytokines IL-6 and [IL-1beta] , the chemokines MCP-1 and IL-8 , and the vasoconstrictor ET-2 in PTEC . Positive_regulation IL1B TNF 11856644 914386 Furthermore , both compounds were able to inhibit *induced* [IL-1beta] , but not IL-6 , increase . Positive_regulation IL1B TNF 11872267 918546 The production of and IL-6 was *induced* by [IL-1beta] and Abeta [ 25-35 ] and synergistically amplified by the co-stimulation of IL-1beta and Abeta [ 25-35 ] . Positive_regulation IL1B TNF 11886171 919897 We found that the serum content of inflammatory cytokines IL-8 , [IL-1beta] , and monocyte chemoattractant protein 1 ( MCP-1 ) are *increased* during AP. Injection of IT9302 or mon . IL-8 antibody , diminish the concentration of these cytokines in the serum , with the exception that mon . IL-8 antibody actually increased the circulating level of MCP-1 . Positive_regulation IL1B TNF 11943316 928693 The objectives of this study were to determine [interleukin (IL)-1 beta] , IL-2 , IL-4 , IL-5 , IL-6 , IL-8 , IL-10 , interferon (IFN)-gamma and *induction* in bronchoalveolar lavage (BAL) of control horses and horses with heaves both during remission and exacerbation of the disease , and to determine the effect of therapy with inhaled fluticasone propionate on the cytokine profile of horses with heaves . Positive_regulation IL1B TNF 12056510 951861 did not affect TNFR-1 expression in the liver and *resulted* in time dependent up-regulation of iNOS , [IL-1beta] and HO-1 . Positive_regulation IL1B TNF 12137744 969020 The inhibitors SB203580 , PD98059 , SN50 , cycloheximide and D-ribofuranosylbenzimidazole each reduced the basal and *stimulated* secretion of [IL-1beta] and also reduced IL-6 secretion with the exception of SN50 . Positive_regulation IL1B TNF 12228766 988125 Captopril impaired production of *induced* [interleukin-1beta] in human monocytes is associated with altered intracellular distribution of nuclear factor-kappaB . Positive_regulation IL1B TNF 12228766 988128 Thus captopril reduced *induced* [IL-1beta] and IL-1betamRNA synthesis in monocytes , in vitro , probably through interference with NF-kappaB activation of the IL-1beta gene . Positive_regulation IL1B TNF 12359166 994627 IL-17 and *stimulated* [IL-1beta] release in few subjects . Positive_regulation IL1B TNF 12468033 1022524 We found that IL-1beta induces de novo synthesis of additional IL-1beta but not , as determined by RT-PCR and ELISA , and TNFalpha does not *induce* either itself or [IL-1beta] . Positive_regulation IL1B TNF 12571133 1057367 Before antioxidants , *increased* by 60 % , [IL-1beta] by threefold , and IL-6 by sixfold secondary to exercise ( P < 0.05 ) . Positive_regulation IL1B TNF 12576959 1058169 Endogenous nitric oxide may be an important endogenous inhibitor of hyperoxia + *induced* leukocyte recruitment and subsequently tumor necrosis factor-alpha , [interleukin-1 beta] , and GRO/CINC-1 release . Positive_regulation IL1B TNF 12595589 1061695 Fetal human enterocytes have an exaggerated IL-8 secretion in *response* to and [IL-1beta] . Positive_regulation IL1B TNF 12807444 1102034 Concomitantly , *induced* [IL-1beta] mRNA expression by astrocytes in co-culture and this effect was partially prevented by ET-1 antibody neutralization . Positive_regulation IL1B TNF 13678668 1140185 alone caused robust NO ( 2 ) ( - ) flux , while IL6 had a lesser effect and neither IFNgamma nor [IL1beta] was *active* when applied singly . Positive_regulation IL1B TNF 1421015 202097 Similarly recombinant alone *induced* [IL-1 beta] synthesis only in a few U-937 cells . Positive_regulation IL1B TNF 14630536 1170465 Six hours after irradiation , [IL-1beta] levels had increased in the hypothalamus , thalamus and hippocampus , and and IL-6 levels had *increased* significantly in the hypothalamus . Positive_regulation IL1B TNF 14631304 1170545 PAP and [IL-1B] mRNA levels in the pancreas were significantly *increased* but the increase in mRNA level did not reach statistical significance ( P=0.06 ) . Positive_regulation IL1B TNF 14662866 1177633 [IL-1beta] *induces* a > 10-fold up-regulation of NGAL expression in the type II pneumocyte derived cell line A549 cells , whereas , IL-6 , and LPS had no effect . Positive_regulation IL1B TNF 14710107 1181239 Uterine and cervical [interleukin-1beta] and interleukin-6 were decreased , and uterine *increased* in celecoxib-B . Positive_regulation IL1B TNF 15031635 1183855 These data demonstrate that CQ *inhibits* [IL-1 beta] release from monocytes by interfering with pretranscriptional signaling and release by posttranslational events whereas GST downregulates IL-1 beta secretion by interfering with posttranslational IL-1 beta processing . Positive_regulation IL1B TNF 15036245 1223859 We compared the production of IL-1alpha , [IL-1beta] , and of IL-1Ra isoforms by cultured human dermal ( HDF ) and synovial fibroblasts ( HSF ) in *response* to IL-1alpha , , or direct T cell membrane contact . Positive_regulation IL1B TNF 15194461 1259937 *induced* production of [interleukin-1beta] and monocyte chemoattractant protein-1 from cultured cardiomyocytes was reduced significantly by IMD-0354 . Positive_regulation IL1B TNF 15198989 1273879 In wild-type healthy control , CD and ulcerative colitis individuals , low-dose MDP and alone *results* in only modest [IL-1beta] protein induction . Positive_regulation IL1B TNF 15201199 1295548 The was secreted by amnion and choriodecidua in the presence of LPS or GBS , and stimulation with GBS *induced* a greater synthesis of [IL-1beta] than did stimulation with LPS . Positive_regulation IL1B TNF 15240722 1270434 The production of TNF and [IL-1beta] was *induced* by membranes of stimulated T cells in the three types of target cells , whereas CD40LT induced production in IFN-gamma-macrophages only . Positive_regulation IL1B TNF 15358691 1293568 In order to better understand the control of IL-1beta activity in the airway mucosa , the *role* ( s ) of , cyclic adenosine monophosphate ( cAMP ) and cyclic guanosine monophosphate ( cGMP ) in the release of [IL-1beta] and its inhibitors by cultured HAECs were examined . Positive_regulation IL1B TNF 15358691 1293570 cAMP increased constitutive and *stimulated* [IL-1beta] release but reduced that of sIL-1RII . Positive_regulation IL1B TNF 15380914 1298563 The spontaneous and *stimulated* secretion of [IL-1beta] , IL-8 , IP-10 and MIG from HT-29 and Caco-2 cells was tested with , or without pretreatment with allicin . Positive_regulation IL1B TNF 15483191 1354716 and type I IL-1 receptor ( IL-1RI ) *mediate* the biological functions of TNF-alpha and [IL-1beta] , respectively . Positive_regulation IL1B TNF 15539457 1360648 Blockade of alpha6 integrin inhibits [IL-1beta-] but not *induced* neutrophil transmigration in vivo . Positive_regulation IL1B TNF 15597792 1346559 augments inflammation , TNF and IFN-gamma induce coagulation , and [IL-1beta] *induces* coagulation and fibrinolysis . Positive_regulation IL1B TNF 15672633 1350774 IL-1alpha and [IL-1beta] mRNA expression increased significantly ( p < 0.05 vs. sham-injury ) after severe TBI and IL-6 and mRNA expression *increased* significant ( p < 0.05 vs. sham-injury ) after both moderate and severe TBI . Positive_regulation IL1B TNF 15683451 1370623 The lymph node homing chemokine receptor CCR-7 expression was induced by TNF-alpha + [IL-1beta] + IL-6 + prostaglandin E2 but was not *induced* by Poly I:C + . Positive_regulation IL1B TNF 15708442 1372975 IFN-gamma with interleukin (IL) 1alpha or [IL-1beta] in the *presence* of ; Positive_regulation IL1B TNF 15804596 1390935 A. actinomycetemcomitans clearly *induced* interleukin (IL)-6 , [IL-1beta] , and to a minimal extent , mRNA expression . Positive_regulation IL1B TNF 15917841 1440332 *increased* the mRNA levels of TNFalpha itself as well as IL-6 , IL-8 , [IL-1beta] and PAI-1 , but not leptin . Positive_regulation IL1B TNF 16000387 1447305 In the present study , incubation of AM with unopsonized Pneumocystis organisms was not associated with release of interleukin (IL)-1beta , IL-6 , or ( important cytokines in the host response to Pneumocystis ) and did not *induce* [IL-1beta] , IL-6 , or TNF-alpha mRNA transcripts . Positive_regulation IL1B TNF 16025141 1453419 was *necessary* for the local PAF induced [IL-1beta] production . Positive_regulation IL1B TNF 16211580 1507917 Our results demonstrate a potent and dramatic increase in osteopontin expression *induced* by [interleukin-1beta (IL-1beta)] , whereas , transforming growth factor-beta , and angiotensin II had minimal effect . Positive_regulation IL1B TNF 1639861 194753 Taken together , these data demonstrate that [IL-1 beta] *induces* gene expression in CH235-MG cells in a PKC dependent manner . Positive_regulation IL1B TNF 16549373 1582326 [IL-1beta] and TNFalpha strongly *induced* the expression of MMP-1 and -13 in SW1353 cells and HACs , whereas only was found to induce the expression of these two MMPs in JJ012 cells . Positive_regulation IL1B TNF 1660018 171371 Twenty-four-hour conditioned medium from lipopolysaccharide stimulated peripheral blood monocytes and nonparenchymal human liver cells enriched for Kupffer cells induced a time dependent increase in interleukin-8 messenger RNA levels in SK-hepatoma cells over a 24-hr period , similar to that seen for or [interleukin-1 beta] *induction* of interleukin-8 in primary hepatocytes . Positive_regulation IL1B TNF 16610017 1545260 VacA alone *induced* expression of TNF-alpha , IL-8 and [IL-1beta] , while NaCl alone induced expression of and IL-1beta . Positive_regulation IL1B TNF 16616208 1582986 The expression of IL-1beta , IL-8 , and markedly *increased* in the presence of [IL-1beta] after day 14 of culture . Positive_regulation IL1B TNF 1661739 172708 *Induction* of [interleukin-1 beta] production in human dermal fibroblasts by interleukin-1 alpha and . Positive_regulation IL1B TNF 16859503 1663413 Adhered monocytes , after 3-day preincubation with IL-10 and M-CSF , could produce more [IL-1beta] and IL-6 in *response* to in the presence of dibutyryl cAMP , as compared with the cells preincubated with or without IL-10 or M-CSF alone . Positive_regulation IL1B TNF 1693528 132756 Nuclear run-on analyses showed that IL-1 alpha transcriptionally activated the genes for IL-6 , GM-CSF , and IL-1 beta , while transcriptionally *induced* expression of IL-6 and [IL-1 beta] . Positive_regulation IL1B TNF 17022949 1641527 also *increased* TNFalpha and [IL1beta] mRNAs in the hypothalamus , hippocampus and SSctx . Positive_regulation IL1B TNF 17022949 1641529 *increased* TNFalpha , [IL1beta] and IL10 mRNAs in the NTS , but did not induce any changes in IL-6 mRNA . Positive_regulation IL1B TNF 17075836 1649906 SMV prevented the increase in NF-kappaB activation and rise in [IL-1beta] and IL-6 levels *induced* by , whereas mevalonate and geranylgeranyl pyrophosphate reversed the inhibitory effects of SMV on activation of NF-kappaB and RhoA . Positive_regulation IL1B TNF 1713637 163463 In contrast , IL-1 beta , , and TPA equally *stimulated* increased levels of M-CSF , GM-CSF , [IL-1 beta] and IL-6 RNAs . Positive_regulation IL1B TNF 17203472 1688869 Systemic and LPS administration activated microglia and *increased* expression of brain pro-inflammatory factors ( i.e. , TNFalpha , MCP-1 , [IL-1beta] , and NF-kappaB p65 ) in wild-type mice , but not in TNF R1/R2 ( -/- ) mice . Positive_regulation IL1B TNF 17273796 1691775 However , it was unknown whether curcumin , showing inhibitory effects on NF-kappaB and MAPKs , attenuates the expression of *induced* [IL-1beta] , IL-6 , IL-8 , and TNF-alpha as well as cyclin E expression in HaCaT cells . Positive_regulation IL1B TNF 17273796 1691777 We found that curcumin inhibited the expression of *induced* [IL-1beta] , IL-6 , and TNF-alpha , but not IL-8 , in TNF-alpha treated HaCaT cells as well as the TNF-alpha induced cyclin E expression . Positive_regulation IL1B TNF 17286914 1698371 The combination of TBP and TRBP was able to obviously inhibit both respiratory burst of monocytes induced by TNF-alpha and IFN-gamma and transcription level of [IL-1beta] and IL-8 mRNA *induced* by . Positive_regulation IL1B TNF 17295604 1725899 The data are consistent with a *role* for , and possibly for [IL-1 beta] , in mediating increased bone resorption during estrogen deficiency in women . Positive_regulation IL1B TNF 17320940 1719784 FCAS monocytes respond to mild hypothermia with [IL-1beta] release , which in turn *induces* autocrine transcription and secretion of IL-6 and as well as stimulation of further IL-1beta production . Positive_regulation IL1B TNF 17484771 1778193 LPS induced production of , interleukin-6 (IL-6) , IL-10 and interferon-gamma-inducible protein-10 (IP-10); SA *induced* TNF-alpha , and [IL-1beta] production ; Positive_regulation IL1B TNF 17612514 1786757 Mechanism of *induced* IL-1alpha , [IL-1beta] and IL-6 expression in human cardiac fibroblasts : effects of statins and thiazolidinediones . Positive_regulation IL1B TNF 17612514 1786760 Pharmacological inhibitors and receptor neutralizing antibodies established that both *induced* IL-6 and [IL-1beta] expression was mediated via the TNFRI receptor and p38 mitogen activated protein kinase (MAPK) , phosphoinositide 3-kinase (PI3K)/Akt and nuclear factor (NF)-kappaB pathways . Positive_regulation IL1B TNF 17650656 1775973 No [IL-1beta] and TNF-alpha were *detected* in the synovia in control group , while in the other 3 groups , synovia IL-1beta and levels increased significantly . Positive_regulation IL1B TNF 17706606 1789078 *augmented* [IL-1beta] stimulated release of MMP-9 , but not MMP-2 or -3 . Positive_regulation IL1B TNF 17763959 1866098 Ghrelin caused a decrease in *induced* COX-2 and [IL-1beta] expression in OE-19 cells . Positive_regulation IL1B TNF 17854800 1795916 We further demonstrated that proteasome inhibition augmented [interleukin-1 beta-] and induced *activation* of the IkappaBalpha kinase and MKK4/JNK/c-Jun pathway along with TAK1 activation . Positive_regulation IL1B TNF 17907382 1803277 while in comparison with model group , PGE2 and IL-1beta levels in EA-post-treatment group , [IL-1beta] level in IND group decreased significantly ( P < 0.05 ) , and level in IND group *increased* significantly. No significant differences were found between model group and Rofecoxib and EA-pre-treatment groups in most time-courses of the hind-paw-volume , between model and IND , Rofecoxib and EA-pre-treatment groups in PGE2 , between model and EA-pre-treatment groups in IL-1beta , and between model and Rofecoxib , EA-pre-treatment and EA-post-treatment groups in TNF-alpha contents ( P > 0.05 ) . Positive_regulation IL1B TNF 17940116 1849340 Compared with basal outputs by DCs incubated with E2 , enhanced MMP-1 and MMP-3 secretion by 14 +/- 3- and 9 +/- 2-fold , respectively , and [IL-1beta] *increased* MMP-1 and MMP-3 secretion by 13 +/- 3- and 19 +/- 2-fold , respectively ( P < 0.05 ) . Positive_regulation IL1B TNF 17996674 1821721 Moreover , *induced* expression of cytokines , such as TNF-alpha and [IL-1beta] , and a chemokine , IL-8 , were suppressed by silymarin treatment in human keratinocyte cell line , HaCaT . Positive_regulation IL1B TNF 18372240 1888328 Caspase-3 activity was *increased* by [IL-1beta] and the pro-inflammatory cytokine combination , and to a lesser extent by . Positive_regulation IL1B TNF 18475493 209558 The PDE-IV inhibitors caused a concentration dependent inhibition of production , but only partially *inhibited* [IL-1beta] at high concentrations . Positive_regulation IL1B TNF 18549505 1929271 also *activated* [IL-1beta] gene expression in differentiated adipocytes , but had no effect on endogenous TNF-alpha mRNA levels . Positive_regulation IL1B TNF 18629644 2028054 Propionate and butyrate did not modulate [IL-1 beta-] and induced *activation* of mitogen activated protein kinases ( MAPKs ) , which play a crucial role in MMP induction . Positive_regulation IL1B TNF 18700232 1967916 In lung cell cultures both particle types *induced* release of IL-6 and [IL-1beta] , whereas was only detected upon exposure to St Louis particles . Positive_regulation IL1B TNF 18760623 1975411 After 48 h , also *induced* a significant increase in [IL-1beta] , IL-3 , and IP-10 secretion . Positive_regulation IL1B TNF 18929641 1994584 [Interleukin-1beta] , flagellin , interferon-gamma , and tumor necrosis factor alpha (TNF-alpha) similarly *induced* Nox1 in a colon cancer cell line ( T84 ) , whereas only fully induced NOXO1 and upregulated superoxide producing activity by ninefold . Positive_regulation IL1B TNF 19008124 2041477 Over-expression of miR-9 , miR-98 or miR-146 in isolated human chondrocytes reduced [interleukin-1 beta (IL-1 beta)] *induced* production . Positive_regulation IL1B TNF 19170891 2113947 [IL-1beta] was *detected* in the frontal white matter of all 11 cases where microglial nodules were observed to varying degrees , whereas was detected in seven cases . Positive_regulation IL1B TNF 1918980 168439 We have previously demonstrated that Il-1 and could rapidly , but transiently , *induce* gene expression of [Il-1 beta] in human polymorphonuclear leukocytes ( PMN ) at both the protein and mRNA level . Positive_regulation IL1B TNF 1918980 168443 Using nuclear run-on transcription analysis , we found that within 1 h Il-1 , , and TNF plus Il-1 *induced* the transcription of the [Il-1 beta] gene by 33- , 61- , and 99-fold , respectively . Positive_regulation IL1B TNF 1918980 168445 This abrogation of Il-1 beta mRNA accumulation was not caused by inhibition of induction of Il-1 beta transcription because *induction* of transcription of [Il-1 beta] was not affected by simultaneous treatment with cycloheximide . Positive_regulation IL1B TNF 1918980 168446 Thus , we report that Il-1 and *regulate* [IL-1 beta] gene expression via both transcriptional and post-transcriptional mechanisms in vitro . Positive_regulation IL1B TNF 19231080 2044782 However , *induced* [IL-1beta] generation in both paws and the presence of local IL-1beta in the contralateral paw were essential for the development of bilateral hyperalgesia . Positive_regulation IL1B TNF 19503841 2091979 Secretion of IL-8 from Hela cells infected with C. trachomatis was not dependent on [IL-1 beta] and *induction* . Positive_regulation IL1B TNF 19535263 2109675 IL-1beta vigorously induced the production of CCL20 from FLSs of human RA and the production of CCL20 induced by TNF-alpha was partially attributed to a trace amount of [IL-1beta] *induced* by . Positive_regulation IL1B TNF 19569215 2208818 We added both lipopolysaccharide (LPS)-free and endotoxin associated xUHMWPE and PCU particles to a human monocyte cell line ( TH1 ) in culture and measured cell viability and , interleukin (IL)-1beta , and prostaglandin E ( 2 ) ( PGE ( 2 ) ) in the medium after 24 h. Results indicate that particles ( both xUHMWPE and PCU ) free of endotoxin did not significantly *induce* secretion of TNFalpha , [IL-1beta] , or PGE ( 2 ) above basal levels . Positive_regulation IL1B TNF 19712723 2158131 Interestingly , treatment with EP2 antagonist AH-6809 resulted in suppression of hypoxia *induced* EP2 , [IL-1beta] and iNOS mRNA and protein expression , protein expression and intracellular cAMP level in BV-2 cells . Positive_regulation IL1B TNF 19827118 2271962 LMP1 mediated IL-1alpha and [IL-1beta] production could be *enhanced* by , determined by enzyme linked immunosorbent assay ( ELISA ) . Positive_regulation IL1B TNF 19877072 2160704 Quantitative polymerase chain reaction was performed to detect the *induced* cytokine gene expression of [interleukin-1beta (IL-1beta)] and to investigate the effects of DEX and CpdA in RA fibroblast-like synoviocytes ( FLS ) transfected with small interfering RNA ( siRNA ) against GR ( siGR ) compared with nontransfected cells . Positive_regulation IL1B TNF 20419825 2246674 On day 1 after infection , the secretion of both and IL-6 decreased significantly in the bronchoalveolar lavage fluid prepared from RSV infected offspring exposed to DBDE perinatally , but [IL-1beta] *increased* . Positive_regulation IL1B TNF 2062178 162254 Recombinant human IL-1 beta and *stimulate* production of IL-1 alpha and [IL-1 beta] by vascular smooth muscle cells and IL-1 alpha by vascular endothelial cells . Positive_regulation IL1B TNF 2107353 128724 Stimulation with interleukin-1 beta (IL-1 beta) or *induced* up to 18-fold ( [IL-1 beta] ) or up to fourfold ( TNF alpha ) increases of prostanoid release . Positive_regulation IL1B TNF 2109008 131124 IFN-gamma and [IL-1 beta] alone do not *induce* production , however , the combined treatment of IFN-gamma and IL-1 beta results in a striking synergistic effect on astrocyte TNF-alpha production . Positive_regulation IL1B TNF 2171355 142458 The TNF infusions did not produce detectable circulating [IL-1 beta] nor did they *induce* significant production of or IL-1 beta by circulating blood monocytes . Positive_regulation IL1B TNF 21804481 2462464 We measured gradual increase of levels of [IL-1b] and TXB2 during cross clamping and during reperfusion in group A ( P < 0.05 ) . The levels of *increased* only during reperfusion ( P < 0.05 ) . The concentration of IL-1b and TNFa remained almost stable in group B , whereas the concentration of TXB2 reduced but not significantly ( P > 0.05 ) . Positive_regulation IL1B TNF 2212667 142735 Thus , these studies represent the first demonstration of IL-1 and *induction* of [IL-1 beta] gene expression in the PMN . Positive_regulation IL1B TNF 2221137 142842 These data support the hypotheses that [IL-1 beta] is responsible for a significant part of LPS fever and that *acts* as an endogenous antipyretic to limit the magnitude of LPS fever in the rat . Positive_regulation IL1B TNF 22651847 2643591 Furthermore , we observed rapid and [IL-1b] gene *induction* in conventional primary astrocyte cultures after IL-6 stimulation , which was due to the activation of the Janus kinase/signal transducer and activator of the transcription pathway in contaminating microglia . Positive_regulation IL1B TNF 23077171 2706753 A 48 h , LPS time course study showed that *increased* first at 1 h , followed by peak expression of [IL1B] at 6 h , and those of S100A8 , S100A12 , and LAP at 12 h . Positive_regulation IL1B TNF 24279177 2876955 In non-gravid pigs [IL1beta] , IL6 and *increased* endometrial E1 release only on days 12 to 13 of the estrous cycle . Positive_regulation IL1B TNF 2542408 112266 TGF-beta inhibited in a dose dependent manner the *induction* of [IL-1 beta] by LPS or but not by PHA and PMA . Positive_regulation IL1B TNF 2788284 116865 In addition , simultaneous stimulation with recombinant IL-1 ( alpha or beta ) and recombinant *resulted* in a synergistic increase in [IL-1 beta] mRNA levels . Positive_regulation IL1B TNF 3494060 72249 Induction with TNF resulted in the appearance of IL 1-alpha mRNA and a very significant increase in IL 1-beta mRNA , indicating that *induces* the synthesis of both IL 1-alpha and [IL 1-beta] in FS-4 cells . Positive_regulation IL1B TNF 7473001 331449 Addition of BK , in the *presence* of , for 1 h and 6 h , respectively , synergistically enhanced the TNF alpha induced [IL-1 beta] production , whereas BK alone did not induce IL-1 production . Positive_regulation IL1B TNF 7540572 310058 Furthermore , in the *presence* of , large amounts of NO were produced by [IL-1 beta] and DNA cleavage occurred more noticeably , although TNF-alpha alone did not generate NO . Positive_regulation IL1B TNF 7608561 311946 A cyclic adenosine 3',5'-monophosphate signal is required for the *induction* of [IL-1 beta] by in human monocytes . Positive_regulation IL1B TNF 7640431 317852 [Interleukin 1 beta] and interleukin 6 could not be *detected* at all , whereas alpha levels were marginally elevated before and after HD with both membranes . Positive_regulation IL1B TNF 7649354 319121 Testosterone and *increased* [IL-1 beta] protein release ( P < 0.05 ) while 17 beta-estradiol had little effect on release . Positive_regulation IL1B TNF 7680648 211624 In unstimulated synovial fibroblasts , the expression of mRNA for both chemokines was undetectable , but was increased in both a time- and dose dependent manner upon *stimulation* with the monokines and [interleukin-1 beta (IL-1 beta)] . Positive_regulation IL1B TNF 7686496 222174 Intracellular IL-1 alpha and [IL-1 beta] levels were markedly *enhanced* by IL-1 beta and . Positive_regulation IL1B TNF 7743669 306075 LPS , IFN-gamma or had no effect on spontaneous IL-6 production , and neither *resulted* in the secretion of [IL-1 beta] or TNF-alpha . Positive_regulation IL1B TNF 7786295 309933 The pleiotropic cytokine *induces* the production of [interleukin-1 beta (IL-1)] , and , together , they play significant roles in many acute and chronic inflammatory diseases . Positive_regulation IL1B TNF 7831192 285955 The [IL-1 beta-] and induced *activation* of 5-LO pathway did not appear to be triggered by phospholipase A2 . Positive_regulation IL1B TNF 7994029 283053 Production of granulocyte-macrophage colony stimulating factor ( GM-CSF ) , granulocyte-CSF (G-CSF) , and [interleukin-1 beta (IL-1 beta)] in stromal cell layers was *induced* by incubation with IL-1 alpha , , or lipopolysaccharide (LPS) . Positive_regulation IL1B TNF 8069926 269999 Unlike IL-8 , the LPS stimulated production of TNF and IL-1 beta , as well as the *stimulated* production of [IL-1 beta] , was markedly enhanced by IFN-gamma over the entire incubation period ( up to 18 hr ) . Positive_regulation IL1B TNF 8093640 210078 Furthermore , in U-87 cells , *enhanced* both ICAM-1 and [interleukin-1 beta (IL-1 beta)] expression , and decreased immunoreactivity for transforming growth factor-beta ( TGF-beta ) protein . Positive_regulation IL1B TNF 8162947 254460 The [interleukin-1 beta-] and induced *activation* of 5-lipoxygenase pathway did not appear to be triggered by phospholipase A2 . Positive_regulation IL1B TNF 8273592 239507 Zaprinast *stimulated* [IL-1 beta] and to a lesser extent production . Positive_regulation IL1B TNF 8391053 224155 There was a significant increase of [IL-1 beta] mRNA levels ( unstimulated cells ) on days 1 and 7 , but mRNA levels *increased* significantly on day 1 only . Positive_regulation IL1B TNF 8544101 338862 IL-1 beta activation of GF cells showed that [IL-1 beta] non only *induces* the expression of IL-6 , IL-8 and , but also acts in an autocrine manner of GF cells and induces IL-1 beta expression . Positive_regulation IL1B TNF 8613710 353569 Thus , GM-CSF increases IL-1 beta message accumulation in PMN at both the transcriptional and post-transcriptional levels by mechanisms that are different from *induction* of [IL-1 beta] gene expression . Positive_regulation IL1B TNF 8640449 362652 Neither [IL-1 beta] protein nor message was detected at any point , and synthesis never *increased* above constituted levels . Positive_regulation IL1B TNF 8653494 366577 , in contrast to PHT , dose-dependently *stimulated* the production of cell associated [IL-1 beta] . Positive_regulation IL1B TNF 8653494 366580 The production of [IL-1 beta] *induced* by and the combination of TNF alpha and PHT was further enhanced in the presence of the prostaglandin endoperoxide ( PGH ) synthase inhibitors , indomethacin and flurbiprofen . Positive_regulation IL1B TNF 8653494 366581 The PHT mediated enhancement of *induced* [IL-1 beta] production and PGE2 formation in gingival fibroblasts may be an important link in the pathogenesis of gingival overgrowth induced by PHT . Positive_regulation IL1B TNF 8682145 372535 Our results indicate that the leukocyte derived production of IL-6 and [IL-1 beta] in whole blood is stimulated directly by endotoxin and is not *mediated* by . Positive_regulation IL1B TNF 8840155 386691 The data provide evidence for an in vivo *role* for epidermal IL-1 alpha , IL-1 beta and transcription in the regulation of [IL-1 beta] and TNF-alpha polypeptide levels in the epidermis in response to this common contact allergen . Positive_regulation IL1B TNF 8872182 389643 While beta-casein had no significant effects on IFN gamma production by ovine blood lymphocytes , and production and MCH Class II antigen expression by ovine bronchoalveolar macrophages , it *enhanced* [IL-1 beta] production by the macrophages , beta-casein also had no influence on bovine NK cell activity against a virally infected cell line . Positive_regulation IL1B TNF 8918573 396316 They have been shown previously to produce the cytokine [IL-1 beta] in *response* to stimulation with . Positive_regulation IL1B TNF 8973628 403053 During normoxia , LPS was the most potent stimulus , inducing the release of each cytokine , while fMLP showed a less pronounced effect on IL-8 and [IL-1 beta] production and markedly *inhibited* production . Positive_regulation IL1B TNF 8997393 404607 Lipopolysaccharides (LPS) , [interleukin-1 beta] , interferon-gamma (IFN-gamma) , and *increase* the levels of Fas mRNA in cultured mesangial and tubular cells . Positive_regulation IL1B TNF 9013629 411738 Here we show that a tissue-type TGase is expressed in rat brain astrocytes in vitro , and is *induced* by the inflammation associated cytokines [interleukin-1beta] and to a lesser extent by . Positive_regulation IL1B TNF 9013944 411822 Thus , IFN-gamma and [IL-1beta] levels were *increased* 13-fold and 30-fold , respectively , with more modest increases in IL-6 levels ( 5-fold ) and levels ( 2-fold ) . Positive_regulation IL1B TNF 9029130 413588 Production and release of bFGF is *induced* in a synergistic fashion by , [IL-1beta] , and IFN-gamma , and its release is further promoted by low cell density and by the serine proteases plasmin and thrombin . Positive_regulation IL1B TNF 9166282 432338 These results provide new evidence that IL-8 as well as are the most proximal cytokines and *induce* subsequent production of [IL-1 beta] and IL-1Ra . Positive_regulation IL1B TNF 9329125 457452 Treatment of the Caco-2 cells with [IL-1 beta] *induced* expression of IL-6 mRNA with a response noticed after 30 min . and IL-6 did not influence the production of IL-6 in the Caco-2 cells . Positive_regulation IL1B TNF 9366717 463332 [Interleukin 1 beta] and gene *induction* was assessed by quantitative competitive reverse-transcription polymerase chain reaction and cytokine protein production was determined by enzyme linked immunosorbent assay . Positive_regulation IL1B TNF 9435641 474752 and 3 ) inhibition of and enhancement of IL-10 both *contributed* to epinephrine induced inhibition of [IL-1 beta] production . Positive_regulation IL1B TNF 9505146 491286 [IL-1 beta] , and to a lesser extent , and IL-4 *increased* NEP activity and expression , whereas IFN-gamma decreased NEP . Positive_regulation IL1B TNF 9506955 491502 Two closely related IkappaBalpha kinases as well as the upstream kinase , NIK , which integrates [interleukin-1beta (IL-1beta)-] and dependent *activation* of the transcription factor NF-kappaB have recently been described . Positive_regulation IL1B TNF 9551998 499167 *Induction* of inducible nitric-oxide synthase (iNOS) , [IL-1beta] , and IL-8 genes by IL-1beta , , or PMA was blocked in Ad5 IkappaB infected cells but not in Ad5 LacZ controls as assayed by RT-PCR and ELISA . Positive_regulation IL1B TNF 9691088 523119 Reverse transcriptase polymerase chain reaction was used to confirm that + LPS + IFN-gamma *stimulates* the expression of both IL-1alpha and [IL-1beta] in human islets . Positive_regulation IL1B TNF 9712064 527153 Reverse-transcription PCR analysis indicated up-regulation of mRNA for IL-8 as well as for [IL-1 beta] in *response* to tryptase or . Positive_regulation IL1B TNFRSF11B 19301089 2094040 In group 1 ( risedronate plus calcium/vitamin D-treated patients ) , serum levels of RANKL and [IL-1beta] significantly decreased and the level of significantly *increased* after three and 6 months , but no significant difference was found in TNF-alpha level . Positive_regulation IL1B TNFRSF11B 20204061 2181005 These results suggest that [IL-1beta] suppresses the formation of osteoclast-like cells via increased OPG production and decreased M-CSF production in chondrocytes , and production may *increase* through an autocrine mechanism involving celecoxib related PGs . Positive_regulation IL1B TNFRSF1B 11950256 930296 TNFalpha-antagonists infliximab and inhibited TNFalpha induced NO production in a dose dependent manner but they *had* no effect on [IL-1beta-] , IL-17- and LPS stimulated NO synthesis . Positive_regulation IL1B TNFRSF1B 18515164 1934180 To summarize , presence of [IL-1beta] increases the expression of IL-1 R1 and TNF RI and *induces* expression of in the airway wall . Positive_regulation IL1B TNFRSF9 19676073 2132866 Cross linking of , a member of the TNF family , with recombinant CD137-Fc ( rCD137-Fc ) protein enhanced adherence of bone marrow derived macrophages , and *increased* the expression of ICAM-1 , [IL-1beta] , IL-6 , M-CSF and phosphotyrosine proteins . Positive_regulation IL1B TNFSF10 17476690 1772258 On the other hand , recombinant *up-regulated* the expression of several cytokines ( [IL-1beta] , IL-1alpha , IL-8 ) , which have been involved in promoting B-CLL cell survival . Positive_regulation IL1B TNFSF10 17476690 1772259 In particular , selectively *up-regulated* [IL-1beta] in Zap-70 ( low ) B-CLL samples , while it markedly and selectively up-regulated its own mRNA and that of cyclooxigenase-2 (COX-2) in Zap-70 ( high ) . Positive_regulation IL1B TNFSF11 17559635 1753256 [Interleukin-1beta] *induced* expression at the mRNA and protein levels , as well as RANKL activity in human periodontal ligament cells . Positive_regulation IL1B TNFSF11 17586708 1764343 These findings indicate that [IL-1beta] is an autocrine factor regulating compressive force induced RANKL expression in PDL cells , and that intermittent force can effectively *induce* in PDL cells with less cell damage . Positive_regulation IL1B TNFSF11 18786965 1976017 expression was *induced* by IL-6/sIL-6R ( but not IL-6 alone ) and by [IL-1beta] . Positive_regulation IL1B TNIP1 15722346 1396013 This is associated with an *induced* decrease in allergen-specific immunoglobulin E levels in serum , as well as a significant reduction of eotaxin , interleukin-4 , and [interleukin-1beta] in bronchoalveolar lavage fluid . Positive_regulation IL1B TRPV1 19584302 2149739 In contrast , TRPV1 sensitization caused by bradykinin , [IL-1beta] , and artemin was insensitive to inhibition of SNARE dependent vesicular fusion and was not *due* to an increase in surface expression . Positive_regulation IL1B TSPAN31 9343751 459044 also *induced* the release of TNF-alpha and [IL-1 beta] by human monocytes . Positive_regulation IL1B TSPAN7 17620096 1769841 In cultured keratinocytes , [IL-1beta] and Th1 cytokines significantly *induced* compared with hS100A15-S . Positive_regulation IL1B TXN 16207716 1483382 Extracellular human inhibits lipopolysaccharide *induced* [interleukin-1beta] expression in human monocyte derived macrophages . Positive_regulation IL1B TXN 19561107 2104177 Not only silencing of , but also of the ROS scavenger superoxide dismutase 1 results in *inhibition* of [IL-1beta] secretion . Positive_regulation IL1B TYR 8176258 255788 We have now also shown that [interleukin-1 beta] *induces* an inhibiting effect on neonatal melanocyte activity with little effect on melanocyte proliferation . Positive_regulation IL1B UBE2N 19854138 2155762 We demonstrate that K63 of ubiquitin and the catalytic activity of , an E2 that catalyzes K63 polyubiquitination , are *required* for IKK activation by [IL-1beta] , but surprisingly , not by TNFalpha . Positive_regulation IL1B VCAM1 10669630 665772 Experiments with blocking antibodies demonstrated that binding of monocyte very late antigen-4 (VLA-4) to endothelial ( VCAM-1 ) was *necessary* for the induction of [IL-1beta] in monocytes . Positive_regulation IL1B VCAM1 12124212 965699 Because IL-18 is a proinflammatory cytokine known to mediate the production of TNF-alpha and [IL-1beta] and to *induce* the expression of intercellular adhesion molecule-1 ( ICAM-1 ) and ( VCAM-1 ) , we hypothesized that neutralization of IL-18 would attenuate lipopolysaccharide (LPS) induced cardiac dysfunction . Positive_regulation IL1B VCAM1 15707597 1372899 Trophoblast interactions with endothelial cells are increased by [interleukin-1beta] and tumour necrosis factor alpha and *involve* and alpha4beta1 . Positive_regulation IL1B VCAM1 19281832 2072889 These findings suggested that [IL-1beta] *induced* expression via these multiple signaling pathways in HTSMCs . Positive_regulation IL1B VCAM1 7529998 291552 Here , we demonstrate that TNF-alpha and [IL-1 beta] transiently *induced* mRNA expression in a time dependent manner . Positive_regulation IL1B VCAM1 7537041 300339 Tumor necrosis factor alpha and [interleukin-1 beta] but not interferon gamma *induce* expression on primary cultured murine hepatocytes . Positive_regulation IL1B VCAM1 7556162 327624 Although is also *induced* by the cytokine [interleukin 1 beta (IL-1 beta)] , activation of the dsRNA activated protein kinase ( PKR ) occurs only in response to incubation with dsRNA but not with IL-1 beta . Positive_regulation IL1B VCAM1 8605994 352520 A benzothiophene-carboxamide is a potent inhibitor of [IL-1beta] *induced* gene expression in human endothelial cells . Positive_regulation IL1B VCAM1 8639172 362515 We found that AECA IgG from WG patients do not display any significant cytotoxicity but are able to up-regulate the expression of E-selectin , intercellular adhesion molecule 1 and and to *induce* the secretion of [IL-1 beta] , IL-6 , IL-8 , and MCP-1 . Positive_regulation IL1B VCAM1 9409229 471427 In cultured human smooth muscle cells from coronary arteries and saphenous veins , tumor necrosis factor-alpha (TNF-alpha) and [interleukin-1 beta (IL-1 beta)] *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular cell adhesion molecule ( ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation IL1B VCAM1 9537837 492368 Astroglioma cell lines as well as primary human fetal astrocytes expressed low levels of constitutively , and the proinflammatory cytokines *induced* marked increases in VCAM-1 expression , particularly TNF-alpha and [IL-1beta] . Positive_regulation IL1B VCAM1 9663488 518380 [Interleukin-1beta (IL-1beta)] and tumor necrosis factor alpha (TNFalpha) further *induced* and ICAM-1 messenger RNA and protein expression . Positive_regulation IL1B VEGFA 11023800 762616 [IL-1beta] , expressed by the blastocyst , *induces* ( VEGF ) which , in turn , promotes angiogenesis and integrin expression in endometrial cells . Positive_regulation IL1B VEGFA 11040101 741914 Together , these results indicate that [IL-1 beta] *induces* gene expression at both transcriptional and post-transcriptional levels , and IL-1 beta evokes p38 MAPK and JNK signalings , which in turn stimulate the transcription of the VEGF gene through Sp1 binding sites . Positive_regulation IL1B VEGFA 11806247 892602 As pericytes play a role in regulating EC function , we hypothesized that [IL-1 beta] may *mediate* EC survival by induction of in a paracrine manner . Positive_regulation IL1B VEGFA 11806247 892605 These data demonstrate that [IL-1 beta] may *induce* in hVSMCs , and suggest that this paracrine signaling pathway , may prevent , in part , apoptosis of ECs . Positive_regulation IL1B VEGFA 14960485 1242920 Meanwhile , [IL-1 beta] also *induced* the secretion of in normal human cytotrophoblast cells . Positive_regulation IL1B VEGFA 14960485 1242922 These data indicate that , in normal human cytotrophoblast cells , [IL-1 beta] *induces* HIF- 1 alpha mediated secretion and that IL-1 beta stimulated ERK1/2 activation may be involved in this process . Positive_regulation IL1B VEGFA 14991903 1215655 Furthermore , *induced* [IL-1beta] , IL-6 , TNF-alpha , and nitric oxide expression to a small extent and stimulated the proliferation of immortalized chondrocytes . Positive_regulation IL1B VEGFA 17015745 1629871 Suggesting functional significance , we found that expression of [IL-1beta] in the brain *induced* astrocytic expression of HIF-1alpha , , and BBB permeability . Positive_regulation IL1B VEGFA 17035941 1649228 [IL-1beta] *induces* , independently of PGE2 induction , mainly through the PI3-K/mTOR pathway in renal mesangial cells . Positive_regulation IL1B VEGFA 7814392 292632 Together these data indicate that [IL-1 beta] *induces* gene expression in smooth muscle cells . Positive_regulation IL1B VIP 16095565 1448115 Furthermore , [IL-1beta] stimulated IL-6 promoter activity in the osteoblastic cell line MC3T3-E1 stably transfected with a human IL-6 promoter/luciferase construct , and both , and the related neuropeptide PACAP-38 , *increased* the effect of IL-1beta in a synergistic manner . Positive_regulation IL1B VIP 2036955 159767 In the *presence* of and PGE2 , IL-1 alpha and [IL-1 beta] increased IL-6 release without any apparent further change in extracellular or intracellular cAMP . Positive_regulation IL1B VIP 7572275 328880 [Interleukin-1 beta (IL-1 beta)] was also *increased* ( EC 50 : 1 nM ) in the medium by but without depleting IL-1 beta in the cytosol . Positive_regulation IL1B VIP 8982099 403803 We have found that GRP , NPY , somatostatin and *stimulated* the production of [IL-1 beta] in old subjects , and NPY , somatostatin and VIP in young ones . Positive_regulation IL1B WDR34 19521662 2108935 Overexpression of *inhibited* [IL-1beta-] , polyI : C- and lipopolysaccharide (LPS) induced but not TNFalpha induced NF-kappaB activation , whereas knockdown of WDR34 by a RNA-interference construct potentiated NF-kappaB activation by these ligands . Positive_regulation IL1B WDR61 10447739 577422 We conclude that CRH and can *induce* the expression of [IL-1beta] , but this is not obligatory for increased PGE2 release , and the effect of these stimuli on COX-2 expression is a direct , IL-1beta independent effect . Positive_regulation IL1B WDR61 16025141 1453423 TNF-alpha was necessary for the local *induced* [IL-1beta] production . Positive_regulation IL1B WDR61 16439466 1554561 H ( 2 ) O ( 2 ) causes formation of [IL-1beta] that may *induce* production of in the muscle , possibly closing a self sustaining cycle of production of inflammatory mediators . Positive_regulation IL1B WDR61 16829183 1591462 Both TNF-alpha and [IL-1beta] induced HUVEC platelet activating factor (PAF) production and was *required* for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine ) . Positive_regulation IL1B WDR61 1710753 158266 , alone and in combination with endotoxin , *caused* an increase in mRNA levels for [IL-1 beta] . Positive_regulation IL1B WDR61 8080039 270830 [Interleukin-1 beta] and tumor necrosis factor-alpha *induce* production by endothelium , and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist . Positive_regulation IL1B WNK1 17320050 1711695 NMDA induced [interleukin-1beta] expression is *mediated* by nuclear factor-kappa B in the retina . Positive_regulation IL1B WNK1 24009751 2836902 Ectopic expression of NFkB in AGS cells *resulted* in about nine-fold transcriptional repression of gastrin both in the presence and absence of [IL1B] . Positive_regulation IL1B WNT11 16754689 1590189 Opposing *roles* of WNT-5A and in [interleukin-1beta] regulation of type II collagen expression in articular chondrocytes . Positive_regulation IL1B WNT5A 16754689 1590190 Opposing *roles* of and WNT-11 in [interleukin-1beta] regulation of type II collagen expression in articular chondrocytes . Positive_regulation IL1B WNT5A 24840810 2950973 Furthermore , exogenous *induced* ( P < .05 ) IL-6 , [IL1B] , MMP2 , MMP9 , and SSP1 mRNA expression in human adipocyte cultures . Positive_regulation IL1B YME1L1 20011701 2175192 A such as lipopolysaccharide can *induce* production of intracellular [pro-IL-1beta] and pro-IL-18 , but not their secretion . Positive_regulation IL1B YY1 10860774 704874 [IL-1 beta] *increases* abundance and activity of the negative transcriptional regulator in neonatal rat cardiac myocytes . Positive_regulation IL1B ZP2 9053458 417241 In the present report we investigated the *role* of microglial receptor in [IL-1 beta] release triggered by LPS . Positive_regulation IL1F10 TNF 20870894 2447331 Messenger ( m ) RNAs for IL-1F6 and IL-1F9 , but not IL-1F5 , IL-1F8 or [IL-1F10] , were significantly *up-regulated* by , IL-1ß , IL-17 and the Toll-like receptor (TLR)3 ligand double stranded ( ds ) RNA . Positive_regulation IL1R1 FAS 15004557 1228058 ligation on macrophages *enhances* [IL-1R1-Toll-like] receptor 4 signaling and promotes chronic inflammation . Positive_regulation IL1R1 IL1B 10704249 672799 Activation of neutral sphingomyelinase by *requires* the type 1 [interleukin 1 receptor] . Positive_regulation IL1R1 IL1B 10925153 718681 *induced* changes in hypothalamic [IL-1R1] and IL-1R2 mRNA expression in the rat . Positive_regulation IL1R1 IL1B 15030977 1223199 markedly *stimulated* the induction of [IL-1R1] , which preceded the induction of iNOS . Positive_regulation IL1R1 IL1B 18515164 1934182 To summarize , presence of *increases* the expression of [IL-1 R1] and TNF RI and induces expression of TNF RII in the airway wall . Positive_regulation IL1R1 IL1B 18566370 1929603 Interestingly , production *promotes* overexpression of the transmembrane form of the IL-1R family member , [IL-1R-like] 1 , also know as ST2 on RAPA conditioned DC ( RAPA-DC ) . Positive_regulation IL1R1 IL1B 22572995 2638063 Collectively , the results indicated that *regulates* expression of [IL1R1] and IL1RAP and stimulates expression of PTGS1 and PTGS2 that are considered to be the most rate limiting enzymes for endometrial synthesis of PGs during the peri-implantation period of pregnancy in pigs . Positive_regulation IL1R1 IL1B 23351058 2809583 *up-regulated* both the signaling [IL1R1] and the inhibitory IL1R2 , while adding hCG further increased IL1R1 and significantly downregulated IL1R2 . Positive_regulation IL1R1 IL1B 8422241 210703 [Interleukin 1 receptor] on fibroblasts from systemic sclerosis patients *induces* excessive functional responses to . Positive_regulation IL1R1 IL1B 9314581 455677 *regulates* Vero cell [interleukin-1 receptor type I] messenger ribonucleic acid expression . Positive_regulation IL1R1 TNF 11170718 783679 As in astrocytes , IL-1 and *induced* expression of [IL-1R1] . Positive_regulation IL1R2 BACE1 17307738 1719151 Surprisingly , the beta-secretase and its homolog BACE2 *increased* [IL-1R2] secretion resulting in C-terminal fragments nearly identical to the ones generated by the alpha-secretase-like cleavage . Positive_regulation IL1R2 BACE2 17307738 1719152 Surprisingly , the beta-secretase BACE1 and its homolog *increased* [IL-1R2] secretion resulting in C-terminal fragments nearly identical to the ones generated by the alpha-secretase-like cleavage . Positive_regulation IL1R2 CASP1 22898816 2682867 Toll or [interleukin-1 receptor] ( TIR ) domain containing adaptor *inducing* interferon-ß ( TRIF ) -mediated protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome mediated host defense against enteropathogens . Positive_regulation IL1R2 CASP10 22898816 2682868 Toll or [interleukin-1 receptor] ( TIR ) domain containing adaptor *inducing* interferon-ß ( TRIF ) -mediated protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome mediated host defense against enteropathogens . Positive_regulation IL1R2 CASP12 22898816 2682879 Toll or [interleukin-1 receptor] ( TIR ) domain containing adaptor *inducing* interferon-ß ( TRIF ) -mediated protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome mediated host defense against enteropathogens . Positive_regulation IL1R2 CASP14 22898816 2682869 Toll or [interleukin-1 receptor] ( TIR ) domain containing adaptor *inducing* interferon-ß ( TRIF ) -mediated protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome mediated host defense against enteropathogens . Positive_regulation IL1R2 CASP16 22898816 2682880 Toll or [interleukin-1 receptor] ( TIR ) domain containing adaptor *inducing* interferon-ß ( TRIF ) -mediated protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome mediated host defense against enteropathogens . Positive_regulation IL1R2 CASP2 22898816 2682870 Toll or [interleukin-1 receptor] ( TIR ) domain containing adaptor *inducing* interferon-ß ( TRIF ) -mediated protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome mediated host defense against enteropathogens . Positive_regulation IL1R2 CASP3 22898816 2682871 Toll or [interleukin-1 receptor] ( TIR ) domain containing adaptor *inducing* interferon-ß ( TRIF ) -mediated protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome mediated host defense against enteropathogens . Positive_regulation IL1R2 CASP4 22898816 2682872 Toll or [interleukin-1 receptor] ( TIR ) domain containing adaptor *inducing* interferon-ß ( TRIF ) -mediated protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome mediated host defense against enteropathogens . Positive_regulation IL1R2 CASP5 22898816 2682873 Toll or [interleukin-1 receptor] ( TIR ) domain containing adaptor *inducing* interferon-ß ( TRIF ) -mediated protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome mediated host defense against enteropathogens . Positive_regulation IL1R2 CASP6 22898816 2682874 Toll or [interleukin-1 receptor] ( TIR ) domain containing adaptor *inducing* interferon-ß ( TRIF ) -mediated protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome mediated host defense against enteropathogens . Positive_regulation IL1R2 CASP7 22898816 2682875 Toll or [interleukin-1 receptor] ( TIR ) domain containing adaptor *inducing* interferon-ß ( TRIF ) -mediated protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome mediated host defense against enteropathogens . Positive_regulation IL1R2 CASP8 22898816 2682876 Toll or [interleukin-1 receptor] ( TIR ) domain containing adaptor *inducing* interferon-ß ( TRIF ) -mediated protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome mediated host defense against enteropathogens . Positive_regulation IL1R2 CASP9 22898816 2682877 Toll or [interleukin-1 receptor] ( TIR ) domain containing adaptor *inducing* interferon-ß ( TRIF ) -mediated protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome mediated host defense against enteropathogens . Positive_regulation IL1R2 IFNB1 19741489 2168236 Mechanical ventilation induces a [Toll/interleukin-1 receptor] domain containing adapter inducing *dependent* inflammatory response in healthy mice . Positive_regulation IL1R2 IFNB1 21926109 2506930 However , the expression of [toll-interleukin1 receptor] domain containing adapter *inducing* ( TRIF ) and TRAF 3 , which act via the TRIF dependent pathway of TLR signaling , were found to be unaffected in TAM . Positive_regulation IL1R2 IL1B 10704249 672801 Activation of neutral sphingomyelinase by *requires* the type 1 [interleukin 1 receptor] . Positive_regulation IL1R2 IL1B 10925153 718682 *induced* changes in hypothalamic IL-1R1 and [IL-1R2] mRNA expression in the rat . Positive_regulation IL1R2 IL1B 23351058 2809584 *up-regulated* both the signaling IL1R1 and the inhibitory [IL1R2] , while adding hCG further increased IL1R1 and significantly downregulated IL1R2 . Positive_regulation IL1R2 IL1B 8422241 210704 [Interleukin 1 receptor] on fibroblasts from systemic sclerosis patients *induces* excessive functional responses to . Positive_regulation IL1R2 IRAK4 12538665 1050240 Inhibition of [interleukin 1 receptor/Toll-like] receptor signaling through the alternatively spliced , short form of MyD88 is *due* to its failure to recruit . Positive_regulation IL1R2 IRF3 23717062 2523068 In HEK293 cells G-Rp1 did not suppress TANK binding kinase 1- , [Toll-interleukin-1 receptor-domain] containing adapter inducing interferon-ß ( TRIF ) - , TRIFrelated adaptor molecule (TRAM)- , or *activation* of and nuclear factor ( NF ) -?B by the myeloid differentiation primary response gene ( MyD88 ) -induced . Positive_regulation IL1R2 JUN 10383449 624588 Because it has been shown that members of the TRAF family are involved in *activation* of NF-kappaB and the by the [interleukin-1 receptor] and members of the TNF receptor superfamily , a role of TRAF1 in receptor cross-talk and/or feedback regulation of activated receptor signaling complexes can be suggested . Positive_regulation IL1R2 MAP3K7 18794297 1986454 The kinase activity of IL-1 receptor associated kinase 4 is required for [interleukin-1 receptor/toll-like] receptor *induced* dependent NFkappaB activation . Positive_regulation IL1R2 MYD88 16412507 1581705 The [interleukin-1 receptor/toll-like] receptor ( IL-1R/TLR ) superfamily signaling *involves* myeloid differentiation factor 88 ( ) that acts as an important adapter protein . Positive_regulation IL1R2 MYD88 22505629 2613184 ISIS 147420 toxicity was independent of Toll-like receptors , because there was no decrease in IFN-ß in [Toll/interleukin-1 receptor-domain] containing adapter *inducing* IFN-ß or mice . Positive_regulation IL1R2 NFKB1 10383449 624589 Because it has been shown that members of the TRAF family are involved in *activation* of and the c-Jun N-terminal kinase (JNK) by the [interleukin-1 receptor] and members of the TNF receptor superfamily , a role of TRAF1 in receptor cross-talk and/or feedback regulation of activated receptor signaling complexes can be suggested . Positive_regulation IL1R2 NFKB1 18794297 1986455 The kinase activity of IL-1 receptor associated kinase 4 is required for [interleukin-1 receptor/toll-like] receptor *induced* TAK1 dependent activation . Positive_regulation IL1R2 NLRP3 22898816 2682878 Toll or [interleukin-1 receptor] ( TIR ) domain containing adaptor inducing interferon-ß ( TRIF ) -mediated caspase-11 protease production integrates Toll-like receptor 4 (TLR4) protein- and inflammasome *mediated* host defense against enteropathogens . Positive_regulation IL1R2 RELA 10383449 624590 Because it has been shown that members of the TRAF family are involved in *activation* of and the c-Jun N-terminal kinase (JNK) by the [interleukin-1 receptor] and members of the TNF receptor superfamily , a role of TRAF1 in receptor cross-talk and/or feedback regulation of activated receptor signaling complexes can be suggested . Positive_regulation IL1R2 RELA 18794297 1986456 The kinase activity of IL-1 receptor associated kinase 4 is required for [interleukin-1 receptor/toll-like] receptor *induced* TAK1 dependent activation . Positive_regulation IL1R2 SMAD6 16951688 1615669 negatively *regulates* [interleukin 1-receptor-Toll-like] receptor signaling through direct interaction with the adaptor Pellino-1 . Positive_regulation IL1R2 SMPD2 10704249 672800 Activation of by IL-1beta *requires* the type 1 [interleukin 1 receptor] . Positive_regulation IL1R2 SOD2 21045076 2443091 Inhibition of *reduced* the PMA induced respiratory burst and IL1A , IL-1R1 , [IL-1R2] and IL8RA gene expression in neutrophil differentiated HL60 cells . Positive_regulation IL1R2 ST2 15004556 1228052 We show here that the membrane bound form of negatively *regulated* type I [interleukin 1 receptor] ( IL-1RI ) and Toll-like receptor 4 (TLR4) but not TLR3 signaling by sequestrating the adaptors MyD88 and Mal . Positive_regulation IL1R2 TAB1 18794297 1986453 The kinase activity of IL-1 receptor associated kinase 4 is required for [interleukin-1 receptor/toll-like] receptor *induced* dependent NFkappaB activation . Positive_regulation IL1R2 TNF 21862654 2486521 Among inflammatory cytokine related genes , blockade *reduced* expression of [interleukin (IL)-1 receptor type 2] , interferon-? receptors , IL6 , IL6 receptor , gp130 , and IL17 receptors . Positive_regulation IL1R2 TRAF3 21926109 2506929 However , the expression of [toll-interleukin1 receptor] domain containing adapter *inducing* interferon beta ( TRIF ) and , which act via the TRIF dependent pathway of TLR signaling , were found to be unaffected in TAM . Positive_regulation IL1R2 TRAF6 16378096 1512546 Association of beta-arrestin and negatively *regulates* Toll-like [receptor-interleukin 1 receptor] signaling . Positive_regulation IL1RAP IL1B 11723165 884123 Using RT-PCR , we first showed that the expression of IL-1RI and IL-1RII , but not [IL-1RacP] , mRNAs are *up-regulated* by in a time dependent manner . Positive_regulation IL1RL1 FOS 8131748 251460 Here we show that [Fit-1] is directly *regulated* by the estrogen-inducible transcription factor and that it belongs to the family of delayed early genes . Positive_regulation IL1RL1 GATA1 22865859 2677391 GATA2 is a critical transactivator for the human IL1RL1/ST2 promoter in mast cells/basophils : opposing *roles* for GATA2 and in human [IL1RL1/ST2] gene expression . Positive_regulation IL1RL1 GATA2 22865859 2677392 GATA2 is a critical transactivator for the human IL1RL1/ST2 promoter in mast cells/basophils : opposing *roles* for and GATA1 in human [IL1RL1/ST2] gene expression . Positive_regulation IL1RN ANGPT1 24563688 2919350 We observed that ( 10 ( -8 ) M ) , but not Ang2 , *increased* mRNA expression of prominent pro-inflammatory cytokine IL-1ß and its natural antagonist [IL-1RA] , by up to 32.6- and 10.0-fold respectively , compared to PBS-control . Positive_regulation IL1RN ANGPT1 24563688 2919353 The effects of extended to the proteins , as Ang1 *increased* intracellular levels of precursor and mature IL-1ß , and extracellular levels of [IL-1RA] proteins , by up to 4.2- , 5.0- and 4.4-fold respectively , compared to PBS-control . Positive_regulation IL1RN IL1B 10381547 624241 In both young and old rats , *induced* a significant up-regulation of cerebellar [IL-1Ra] , IL-1RI , and TGF-beta1 mRNAs ; Positive_regulation IL1RN IL1B 11069732 747852 As expected , highly *stimulated* NO , IL-6 , IL-8 , IL-10 , [IL-1ra] , PGE ( 2 ) and stromelysin synthesis , but dramatically decreased PG production . Positive_regulation IL1RN IL1B 12010575 941239 The levels of [IL-1Ra] were undetectable in culture supernatants of untreated cells , but were significantly *increased* by . Positive_regulation IL1RN IL1B 12548226 1051363 Dexamethasone and interleukin-10 treatment significantly reduced *induced* uterine contractility ( P < .05 ) and amniotic fluid prostaglandins ( P < .05 ) but not interleukin-8 or [interleukin-1 receptor antagonist] . Positive_regulation IL1RN IL1B 12690937 1030517 Plasma rose significantly 2 h after exercise , but plasma [IL-1 ra] *increased* more rapidly and markedly than IL-1 beta , thus IL-1 bioactivity should be blocked at least in the circulation . Positive_regulation IL1RN IL1B 14672890 1189146 In chondrocytes , IFNbeta alone had no effect , but dose dependently enhanced the secretion of [IL1Ra] *induced* by . Positive_regulation IL1RN IL1B 14672890 1189152 In synovial cell lysates , IFNbeta and also *increased* [IL1Ra] levels . Positive_regulation IL1RN IL1B 14982947 1236577 We quantified IL-1Ra , IL-1alpha , and IL-1beta concentrations by enzyme linked immunosorbent assay in intracellular and extracellular fractions from IL-15 induced neutrophils and found that IL-15 does not increase IL-1alpha or production but *induces* [IL-1Ra] release . Positive_regulation IL1RN IL1B 1533284 186442 IL-4 alone ( 0.01-100 ng/ml ) did not stimulate synthesis but rather *induced* [IL-1ra] ( 4.82 +/- 0.94 ng/ml ) . Positive_regulation IL1RN IL1B 15539764 1367531 While the early ( day 1 ) IL-1 antagonist/agonist molar balance offered protection , by days 5 and 7 , a threshold for [IL-1Ra] in the *presence* of increasing expression favored pro-inflammation in the BPD group . Positive_regulation IL1RN IL1B 15751073 1379929 *induced* [IL-1Ra] production was increased by 10 microM rosiglitazone but was reduced dose-dependently by 15-deoxy-PGJ ( 2 ) . Positive_regulation IL1RN IL1B 15751073 1379930 Enhancement of *induced* [IL-1Ra] production by rosiglitazone was not affected by PPARgamma overexpression or by its inhibition with dominant negative PPARgamma or GW-9662 . Positive_regulation IL1RN IL1B 17003335 1618372 Low also *induced* the [IL-1 receptor antagonist (IL-1Ra)] , suppression of which by RNA interference abrogated the beneficial effects of low IL-1beta . Positive_regulation IL1RN IL1B 17429083 1724059 The expression of [interleukin-1-receptor antagonist] is reduced in pancreatic islets of patients with type 2 diabetes mellitus , and high glucose concentrations *induce* the production of in human pancreatic beta cells , leading to impaired insulin secretion , decreased cell proliferation , and apoptosis . Positive_regulation IL1RN IL1B 1831680 165087 In the presence of 1 % AB serum , there was no increase in ( 0.25 +/- 0.13 ng/mL ) but [IL-1ra] production *increased* sevenfold to 3.4 +/- 0.5 ng/mL . Positive_regulation IL1RN IL1B 1831680 165090 GM-CSF or at concentrations that elicited submaximal production of IL-1ra *potentiated* IgG induced [IL-1ra] production . Positive_regulation IL1RN IL1B 19346005 2064709 Depressive symptomatology is associated with decreased and *increased* [interleukin-1 receptor antagonist] levels in males . Positive_regulation IL1RN IL1B 2668014 116177 IL 4 inhibited the generation of IL 1 activity and that of IL 1 alpha and antigens indicating that IL 4 interfered with IL 1 transcription and/or processing rather than *induced* the synthesis of an [IL 1 inhibitor] . Positive_regulation IL1RN IL1B 7485466 326842 *induced* production of both [IL-1Ra] and IL-1 alpha at each time point and concentration tested . Positive_regulation IL1RN IL1B 7485466 326852 These results are suggestive of an autocrine *role* for cell associated [IL-1Ra] , as well as for IL-1 alpha and , in the regulation of VSMC function . Positive_regulation IL1RN IL1B 7802085 284460 Intraamniotic infection or the appearance of in the amniotic fluid *results* in increased production of [interleukin-1 receptor antagonist] . Positive_regulation IL1RN IL1B 8179914 256090 Given that mononuclear phagocytes can produce both the proinflammatory cytokines IL-1 alpha , , and TNF-alpha as well as the suppressive cytokine IL-1ra , we proposed that IL-1 alpha , IL-1 beta , and TNF-alpha may *induce* [IL-1ra] from mononuclear phagocytes . Positive_regulation IL1RN IL1B 8179914 256092 However , IL-1 alpha and were better *inducers* of [IL-1ra] than was TNF-alpha . Positive_regulation IL1RN IL1B 8179914 256093 Furthermore , for *induced* [IL-1ra] , immunoprecipitation of IL-1 beta with an anti-IL-1 beta antibody , but not a preimmune antibody , blocked the induction of IL-1ra . Positive_regulation IL1RN IL1B 8179914 256099 In contrast to mononuclear phagocytes , IL-1 alpha , , and TNF-alpha did not *induce* further [IL-1ra] production in alveolar macrophages . Positive_regulation IL1RN IL1B 8395334 228483 *induces* [interleukin-1 receptor antagonist] and tumor necrosis factor binding protein in humans . Positive_regulation IL1RN IL1B 8698137 372884 IL1 alpha and *caused* a similar increase in AML blast release of [IL1RA] , and addition of anti-IL1 antibodies decreased IL1RA release . Positive_regulation IL1RN IL1B 9572400 501802 On the other hand , there was no change in serum levels of and IL-8 , and the serum levels of [IL-1ra] and IL-6 even *increased* at the end of a single PE , in spite of high levels of all cytokines and adhesion molecules in the plasma filtrate . Positive_regulation IL1RN IL1B 9661623 518148 The regulation of IL-1ra in somatotroph adenoma cells is different from human cultured monocytes , in which significantly *stimulated* [IL-1ra] secretion into the culture supernatants , and no change of intracellular IL-1ra content was observed . Positive_regulation IL1RN IL1B 9692875 523276 We demonstrate that IL-1 contributes to LPS induced IL-1 Ra expression as shown by IL-1 blockade in LPS stimulated monocytes using a specific anti-IL-1beta antibody or recombinant IL-1Ra . Glucocorticoids inhibited *stimulated* [IL-1Ra] mRNA expression and protein production . Positive_regulation IL1RN PGC 22117073 2535039 *Induction* of [IL1Rn] by and AMPK may be involved in the beneficial effects of exercise and caloric restriction and putative anti-inflammatory effects of metformin . Positive_regulation IL1RN TNF 1533322 186451 [IL-1ra] alone at concentrations as high as 1 microgram/mL did not *induce* IL-1 alpha , IL-1 beta , , or IL-6 synthesis . Positive_regulation IL1RN TNF 15627643 1349326 Generally , Co nanoparticles had an overall pro-inflammatory effect on naive macrophages , by reducing anti-inflammatory [IL-1Ra] and *inducing* inflammatory . Positive_regulation IL1RN TNF 16006772 1447360 The levels of circulating interleukin (IL)-6 , IL-8 , macrophage colony stimulating factor ( M-CSF ) and interleukin 1 receptor antagonist ( IL-1ra ) significantly *increased* with the clinical stage of CRC , and the levels of IL-6 , soluble tumor necrosis factor ( sTNF ) receptor type I ( RI ) , soluble interleukin 2 receptor alpha and with tumor grade , while IL-6 , IL-8 , M-CSF , [IL-1ra] and sTNF RI levels significantly rose with bowel wall invasion . Positive_regulation IL1RN TNF 22886741 2719754 Interestingly , [IL-1ra] levels remained always significantly lower than normally reported levels , and levels did not *increase* after trauma . Positive_regulation IL1RN TNF 7851026 294335 also *up-regulated* production of IL-1 alpha , IL-1 beta , [IL-1Ra] and IL-6 by monocytes , but the variability in the results of cells cultured from the same individuals on different occasions was greater . Positive_regulation IL1RN TNF 8158047 253429 is *involved* in the appearance of [interleukin-1 receptor antagonist] in endotoxemia . Positive_regulation IL1RN TNF 8158047 253432 To assess the *role* of in the appearance of [interleukin-1 receptor antagonist] ( IL-1RA ) in endotoxemia , 4 healthy humans were studied after a bolus intravenous injection of recombinant human TNF ( 50 micrograms/m2 ) . Positive_regulation IL1RN TNF 8179914 256088 Given that mononuclear phagocytes can produce both the proinflammatory cytokines IL-1 alpha , IL-1 beta , and TNF-alpha as well as the suppressive cytokine IL-1ra , we proposed that IL-1 alpha , IL-1 beta , and may *induce* [IL-1ra] from mononuclear phagocytes . Positive_regulation IL1RN TNF 8179914 256097 In contrast to mononuclear phagocytes , IL-1 alpha , IL-1 beta , and did not *induce* further [IL-1ra] production in alveolar macrophages . Positive_regulation IL1RN TNF 8331299 223600 *induces* interleukin-1 alpha and [interleukin-1 receptor antagonist] production by cultured human keratinocytes . Positive_regulation IL1RN TNF 8331299 223602 Only *induced* [IL-1ra] and IL-1 alpha production . Positive_regulation IL1RN TNF 8529133 336705 These effects are blocked by [IL-1Ra] and partially *mediated* by . Positive_regulation IL1RN TNF 8698137 372885 [IL1RA] release from AML blasts was also *increased* by stem cell factor , , granulocyte-macrophage colony stimulating factor and macrophage colony stimulating factor , whereas interleukin 3 , interleukin 6 , leukaemia inhibitory factor and granulocyte colony stimulating factor did not significantly alter IL1RA release . Positive_regulation IL1RN TNF 8777273 366027 IL-13 and TGF-beta did not further modulate LPS- and *induced* [IL-1ra] production by PMN . Positive_regulation IL1RN TNF 8786311 358917 In vivo depletion of IL-4 , IL-10 , IL-12 , IFN-gamma , or TNF-alpha with 5 mg of cytokine-specific neutralizing rabbit IgG revealed that IFN-gamma and were *required* for maximal [IL-1ra] production by Mphi . Positive_regulation IL1RN TNF 9166282 432340 These results provide new evidence that IL-8 as well as are the most proximal cytokines and *induce* subsequent production of IL-1 beta and [IL-1Ra] . Positive_regulation IL2 ABCG2 20846001 2375401 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL2 CCL17 22057112 2540320 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL2 CD14 9300716 453879 Functional *role* for the myeloid differentiation antigen in the activation of human monocytes by [IL-2] . Positive_regulation IL2 DAPK1 24220855 2897431 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL2 EPHB2 10843677 700107 [IL-2] *induced* activation within 5 min. Treatment of NK cells with a specific inhibitor of MKK1/2 , PD98059 , during the IL-2 stimulation blocked in a dose dependent manner each of four sequelae , with inhibition of lymphokine activated killing induction being least sensitive to MKK/ERK pathway blockade . Positive_regulation IL2 EPHB2 11489986 845560 Together these results demonstrate that activation of at least and p38 is *essential* for [IL-2] production by CD8 T cells and that up-regulation of these mitogen activated protein kinases , along with Janus kinase , is defective in AINR cells . Positive_regulation IL2 EPHB2 12609986 1085296 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL2 EPHB2 12681450 1077444 This report shows that the PI3K inhibitors LY294002 and wortmannin block *activation* of MEK and by [IL-2] in primary human T cells . Positive_regulation IL2 EPHB2 12946447 1136796 Collectively , these studies suggest that cannabinoid induced inhibition of [IL-2] in PMA/Io stimulated splenocytes might be *due* , in part , to inhibition of MAPK activation . Positive_regulation IL2 EPHB2 15339934 1333559 The inhibition of sustained activation by either expression of a dominant negative B-Raf or treatment with a MEK inhibitor *resulted* in a decrease of the TCR stimulated nuclear factor of activated T cells ( NFAT ) activity and [IL-2] production . Positive_regulation IL2 EPHB2 17458858 1743182 Syk dependent activation *regulates* [IL-2] and IL-10 production by DC stimulated with zymosan . Positive_regulation IL2 EPHB2 18310510 1904117 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL2 EPHB2 20061405 2205503 [IL-2] , which suppresses Th17 differentiation via STAT5 activation , also *acts* through signaling to inhibit Th17 generation . Positive_regulation IL2 EPHB2 21893096 2496542 Furthermore , the activation of phosphorylation and the NFAT promoter by SEP *promoted* the transcription and expression of downstream gene [IL-2] . Positive_regulation IL2 EPHB2 22123847 2542183 Instead , Nef triggers Lck dependent activation of TGN associated signaling to *promote* the production of the T lymphocyte survival factor [IL-2] and to enhance virus spread . Positive_regulation IL2 EPHB2 22753939 2627353 Modulation required de novo protein synthesis , and PI3K , JNK , and activity were *necessary* for enhanced [IL-2] expression , whereas modulation of IL-10 required only PI3K activity . Positive_regulation IL2 EPHB2 23851689 2825153 Ndfip1 and IL-2 have a similar expression pattern , and , following TCR stimulation , expression of both Ndfip1 and [IL-2] *requires* the activity of NFAT and . Positive_regulation IL2 EPHB2 7903276 237855 These observations suggest that concurrent tyrosine phosphorylation of the 42,000 MW and a 100,000 MW protein may be *required* for [IL-2] production . Positive_regulation IL2 EPHB2 8557975 347693 Therefore , we sought to determine whether MEK1 and activities also *stimulate* [IL-2] gene transcription . Positive_regulation IL2 EPHB2 8642312 362946 Our results suggest that defects in both JNK and may *result* in the decreased AP-1 activity and the reduced [IL-2] transcription observed in anergic T cells . Positive_regulation IL2 F2R 7510689 249938 Thrombin and agonist peptide induce early events of T cell activation and *synergize* with TCR cross linking for CD69 expression and [interleukin 2] production . Positive_regulation IL2 F3 7635444 317267 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL2 FAS 17447415 1665563 Stimulation of by agonistic antibodies ( 7C11 ) *resulted* in expression of [IL-2] in primary T cells , which was further enhanced when caspase activity was blocked by ZVAD . Positive_regulation IL2 FAS 22429591 2582802 Consequently , lowered expression of IL-2 and genes *resulted* in decreased [IL-2] secretion and CD95L dependent AICD . Positive_regulation IL2 HRH1 15021962 1221742 Depletion of the *resulted* in decreases in the release of [IL-2] and IL-10 from both CD4+ and CD8+ cells and increases in the release of IL-4 from CD4+ T cells and IFN-gamma from CD8+ cells . Positive_regulation IL2 IL1B 10075017 594822 Using specific enzyme inhibitors of protein kinases ( PK ) C and A , mitogen activated protein kinase (MAPK) , phospholipase A2 (PLA2) , phosphatidylinositol dependent ( PI ) -PLC and PC-PLC , we showed that *induced* [IL-2] synthesis was dependent on all investigated kinases and phospholipases , except PC-PLC . Positive_regulation IL2 IL1B 10656874 578328 NO inhibits *induced* [IL-2] mRNA expression in EL4-6.1 cells . Positive_regulation IL2 IL1B 10836375 697952 *enhanced* [IL-2] production and proliferation of allostimulated resting T cells but its presence was not essential . Positive_regulation IL2 IL1B 11827101 892937 Cell surface phenotype and cytokine secretion in Caco-2 cell cultures : increased RANTES production and [IL-2] transcription upon *stimulation* with . Positive_regulation IL2 IL1B 12711326 1083268 To investigate whether TGZ acts by affecting the ICAM-1/LFA-1 pathway and/or the Th1/Th2 cytokine balance in NOD mice , we analysed the *induced* ICAM-1 expression on islet-cells and the LFA-1 , CD25 , [IL-2] , IFN-gamma , IL-4 , and IL-10 expression on splenocytes . Positive_regulation IL2 IL1B 14617515 1200641 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL2 IL1B 16375968 1547157 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL2 IL1B 2146033 144014 In addition , MAb to the p75 IL-2 receptor on LGL abrogated IL-2 induction of IL-1 beta mRNA , suggesting that [IL-2] signaling via the p75 IL-2 receptor *induced* gene expression in LGL . Positive_regulation IL2 IL1B 2573432 120967 Additional T4 cells require IL1 beta , TNF alpha , IL6 , or AC to become IL2 responsive , whereas only and AC can *promote* [IL2] production . Positive_regulation IL2 IL1B 2965728 91656 Whereas TNF-alpha had little effect , *augmented* [IL-2] mRNA expression and IL-2 production by mitogen stimulated cells . Positive_regulation IL2 IL1B 7540102 290824 Although the expressions of , IL-4 , IL-5 , IL-6 , TNF-alpha and IFN-gamma mRNA were detected in all the embryos tested , the expressions of [IL-2] , IL-3 , IFN-alpha and IFN-beta mRNA were not *detected* at all . Positive_regulation IL2 IL1B 7612386 312936 Immediately after PP , PBM [IL-2] production decreased and PBM production *increased* . Positive_regulation IL2 IL1B 7768308 308381 Based on the utilization of neutralizing antibodies , IL-1 alpha , , and IFN-gamma were not *involved* as soluble mediators during the activation of tumoricidal splenic macrophages by [IL-2] with or without TNF-alpha . Positive_regulation IL2 IL1B 8268417 239402 In the presence of PWM-RBC ( but not of soluble PWM ) , T cell proliferation and [IL-2] production could strongly and consistently be *enhanced* by recombinant and IL-6 . Positive_regulation IL2 IL1B 9029133 413593 in contrast , their levels of , IL-4 , and IFN-gamma were normal and their levels of [IL-2] and TNF-alpha were marginally *increased* . Positive_regulation IL2 IL1R2 8387521 218030 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL2 ITGAL 1358968 200426 Anti-CD3 plus stimulation consistently *induced* the highest secretion of [IL-2] and IFN-gamma , whereas variation in secretion of TNF-alpha and IL-4 between different donors was noted . Positive_regulation IL2 ITGAL 19617540 2118142 In this study , we demonstrate that ADAP and SLP-76-ADAP binding are coupled to *costimulation* of [IL-2] production , F-actin clustering , cell polarization , and T cell motility . Positive_regulation IL2 ITGAL 9531282 496797 These data suggest that engagement of can provide sufficient costimulatory signals to *induce* T cell activation and [IL-2] gene expression , but can not protect against anergy induction or provide for T cell survival . Positive_regulation IL2 ITGB2 11673532 872852 In addition to its well-known role as an adhesion molecule , can *contribute* to T cell activation and up-regulation of [IL-2] gene expression . Positive_regulation IL2 ITGB2 19617540 2118145 A mutant lacking SLP-76 binding sites ( M12 ) blocked *costimulation* of [IL-2] production , polarization , and motility . Positive_regulation IL2 JAG1 11313400 805450 Proliferating gammadelta T cell cultures produced enhanced levels of IFN-gamma and TGF-beta , but not [IL-2] in *response* to the more immunodominant mycobacterial : Depletion of gammadelta T cells from PBMC resulted in an increased Ag-specific proliferation in half the animals tested , indicating a suppressive effect of gammadelta T cells upon other ( alphabeta ) T cell responses . Positive_regulation IL2 JAG1 16818743 1581292 In contrast , Delta1 knockdown in CD4 ( + ) T cells selectively *enhanced* production of IFN-gamma , [IL-2] , and IL-5 in response to polyclonal stimulation , while or Jagged2 knockdown had no effect . Positive_regulation IL2 JAG1 23319735 2738327 Finally , IVE-TB *induced* strong IFN-? ( + ) /TNF-a ( + ) CD8 ( + ) and TNF-a ( + ) [/IL-2] ( + ) CD154 ( + ) /CD4 ( + ) T cell responses in PBMC from long-term latently M. tuberculosis infected individuals . Positive_regulation IL2 MAP2K6 10545489 564539 Suppression of activation of both and p38 MAPK *resulted* in significant inhibition of [IL-2] gene expression . Positive_regulation IL2 MAP2K6 11936754 927954 The specific inhibitor , PD98059 , did not block T-cell adhesion to the various substrates , but it did *block* [IL-2] synthesis . Positive_regulation IL2 MAP2K6 12681450 1077450 This report shows that the PI3K inhibitors LY294002 and wortmannin block *activation* of and ERK by [IL-2] in primary human T cells . Positive_regulation IL2 MAP2K6 15563472 1368148 Pharmacological inhibition of specifically *blocks* [IL-2-] and IL-15 induced translation , whereas p38 , phosphatidylinositol 3-kinase , and mTOR inhibitors had no effect on Ets1 levels . Positive_regulation IL2 MMP28 20639459 2418921 Intracellular calcium flux was augmented in *response* to inhibition or deficiency in the same cells , and [IL-2] production was reduced in CD4 ( + ) and CD8 ( + ) MMP9 ( -/- ) T cells . Positive_regulation IL2 MMP7 20639459 2418936 Intracellular calcium flux was augmented in *response* to inhibition or deficiency in the same cells , and [IL-2] production was reduced in CD4 ( + ) and CD8 ( + ) MMP9 ( -/- ) T cells . Positive_regulation IL2 NEDD9 7905283 240312 Partial inhibition of p50 and expression by NF-kappa B1 antisense oligonucleotides significantly *reduced* T-cell proliferation and [CD25/IL-2R] alpha cell surface expression . Positive_regulation IL2 PCSK9 17996668 1821714 *had* no effect on concanavalin A-induced proliferation , [interleukin (IL)-2] secretion and IL-4 secretion in mouse splenocytes . Positive_regulation IL2 PGC 22117073 2535015 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL2 RAB31 22022086 2499030 Thirty-seven of 92 ( 40.2 % ) patients in the MMF group and 70/113 ( 61.9 % ) patients in the AZA group received [IL-2] *induction* ( P=0.002 ) . 32 patients ( 15.6 % ) developed AR within a year . Positive_regulation IL2 STAT4 17038663 1692800 [IL-2] and IL-18 attenuation of airway hyperresponsiveness *requires* , IFN-gamma , and natural killer cells . Positive_regulation IL2 STAT4 7638186 317680 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL2 STAT4 7760829 308014 In contrast , [IL-2] , IL-3 , and erythropoietin *induce* the tyrosine phosphorylation of Stat5 while IL-12 uniquely induces the tyrosine phosphorylation of . Positive_regulation IL2 STAT4 9886399 584676 [IL-2] *induces* activation in primary NK cells and NK cell lines , but not in T cells . Positive_regulation IL2 STAT4 9886399 584682 In this study , we show that in primary NK cells and NK cell lines , in addition to the activation of STAT1 and STAT5 , [IL-2] *induces* tyrosine phosphorylation of , a STAT previously reported to be activated only in response to IL-12 and IFN-alpha . Positive_regulation IL2 TF 8288726 240796 However , SAC + [IL-2] *induced* receptors normally in low-responders , showing that some early activation steps occur in these cells . Positive_regulation IL2 TLR7 12045249 950120 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL2 TLR7 18312842 1879396 Toxoplasma profilin is essential for host cell invasion and dependent *induction* of an [interleukin-12] response . Positive_regulation IL2 TLR7 20632067 2368005 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in mediated *activation* of caspase 1 and [interleukin-1ß] . Positive_regulation IL2 TLR7 22521509 2613559 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL2 TLR7 23246311 2732091 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL2 TNF 10683986 478639 As compared with pre-operative values , [IL-2] levels in both groups decreased significantly ( P < 0.05 ) , and the levels of sIL-2R , IL-6 , , and IL-10 in both groups *increased* significantly at multiple time points post-operative ( P < 0.01 ) . Positive_regulation IL2 TNF 10706460 579325 Our results indicated that [IL-2] given subcutaneously at a low dose of 100 microg/day for 3 weeks *induced* IFN-gamma and in plasma ( measured 24 hrs after the last dose of IL-2 ) and affected the ability of blood leukocytes to produce cytokines . Positive_regulation IL2 TNF 11089907 751504 Moreover , LPS- or IL-2-stimulation increased the levels of TNF-alpha and NOx in the supernatants of AH-130 cell and macrophage co-culture , although LPS and [IL-2] did not *induce* and NOx production by AH-130 cells incubated without macrophages . Positive_regulation IL2 TNF 12414777 1011168 During the acute phase , IFN-gamma and induced *increases* in [IL-2] , sIL-2R , IL-10 , and sCD30 levels in serum , which allowed the development of immunity characterized by the nonreactivity of the HBV surface antigen , the onset of antibodies to the HBV surface antigen ( anti-HBs ) , and normal alanine aminotransferase levels during the convalescent phase . Positive_regulation IL2 TNF 1353987 192645 [Interleukin-2] *induces* production by activated human T cells via a cyclosporin-sensitive pathway . Positive_regulation IL2 TNF 1420600 202059 Furthermore , [IL-2] production by PHA stimulated MOLT 16 cells was also *augmented* by human in a dose dependent manner . Positive_regulation IL2 TNF 1463043 206760 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL2 TNF 1477494 207487 The data indicate that IFN-gamma and production may be *required* for [IL-2] induction of NK activity , and are consistent with the hypothesis that NK generation involves collaboration between IL-2 and other bone marrow microenvironmental growth factors . Positive_regulation IL2 TNF 1526653 197243 Furthermore , was able to *increase* [IL-2R] alpha mRNA levels on SP thymocytes . Positive_regulation IL2 TNF 15381112 1298607 ERBA did not affect [IL-2-] , IL-3- , and GCSF dependent cell growth , or alpha *induced* growth suppression , nor did ERBA affect osteoclast formation induced by IL-11 , leukemia inhibitory factor , and 1alpha,25-dihydroxyvitamin D ( 3 ) . Positive_regulation IL2 TNF 1651781 164356 This study shows the in vitro effect of LiCl on the *induced* or interleukin 1 (IL-1) induced expression of IL-6 , granulocyte-macrophage colony stimulating factor ( GM-CSF ) , IL-3 , [IL-2] , and the IL-2 receptor-alpha ( IL-2R alpha ) . Positive_regulation IL2 TNF 1661312 172698 These results , combined with the known ability of to *induce* [IL-2R] expression , indicate that TNF and IL-2 form a reciprocating receptor amplification circuit . Positive_regulation IL2 TNF 1667651 176616 In contrast to the effects on IFN , IL-1 and , both cannabinoids , *had* no effect on [IL-2] secretion . Positive_regulation IL2 TNF 1700275 143305 We have previously reported that expression is *induced* by [interleukin-2 (IL-2)] in the murine lymphocytic T-cell line CTLL-2 . Positive_regulation IL2 TNF 1705566 152963 The effect does not occur at 0 degrees C and can not be *induced* by [IL-2] , IL-6 , or GM-CSF . Positive_regulation IL2 TNF 17854477 1795892 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving *dependent* [interleukin-12] induction . Positive_regulation IL2 TNF 17994120 1860083 In addition , fludarabine inhibited *stimulated* production of [IL-2] and IFN-gamma , which play important roles in the onset of GVHD , in Jurkat cells . Positive_regulation IL2 TNF 19019091 2079040 but not IL-12 *increases* the expression of [IL-2Rbeta] on CB Vgamma9 T cells . Positive_regulation IL2 TNF 1906383 161718 GM-CSF , [IL-2] and TNF-alpha directly *induced* the production of cell associated IL-1 but little or no IL-1 or secretion . Positive_regulation IL2 TNF 1937586 170359 [Interleukin 2] *induces* gene expression in vivo . Positive_regulation IL2 TNF 19568710 2104601 The level of CD3 ( + ) , CD4 ( + ) , the ratio of CD4 and CD8 ( + ) , IgA , IgM , IgG and [IL-2] decreased in patients with NSCLC on day 1 after operation , and the level of CD8 and *increased* compared to pre-operation . Positive_regulation IL2 TNF 1972165 135333 IL-2 and IL-4 were both growth promoting for human T cells but only [IL-2] could efficiently *induce* production . Positive_regulation IL2 TNF 20699131 2323225 Functional activation was proved by increased cytokine production of IL-12 , IL-1ß , , and IFN-a/ß , *enhanced* [IL-2] production and proliferation of allogenic T cells , and decreased endocytosis . Positive_regulation IL2 TNF 2108965 131114 [IL-2] alone did not *induce* the expression of either gene while IFN gamma or IFN beta had a modest inductive effect on IP-10 but no effect on expression . Positive_regulation IL2 TNF 2113076 135547 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL2 TNF 21745554 2471917 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL2 TNF 2230118 144602 IL-1 , but not , also *stimulates* transient secretion of [IL-2] . Positive_regulation IL2 TNF 2370931 138350 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL2 TNF 2442261 76936 *Induction* of [interleukin 2] receptor ( TAC ) by in YT cells . Positive_regulation IL2 TNF 2442261 76940 , like IL-1 beta , *induced* increased levels of [IL-2R] expression on YT cells with similar kinetics of induction . Positive_regulation IL2 TNF 2785134 111495 *induces* the expression of [IL-2R] and promotes the proliferation and differentiation of T and B cells . Positive_regulation IL2 TNF 2785134 111496 These findings suggest that *stimulated* expression of the [IL-2R] alpha gene involves the induction of specific DNA binding proteins that in turn interact with a kappa B-like promoter element and facilitate activation of this transcription unit . Positive_regulation IL2 TNF 2793231 119678 We show that the generation of optimal LAK activity by low doses of [IL-2] in the *presence* of involves the induction of high-affinity IL2 receptors on LGL and occurs without promoting significant proliferation , suggesting a functional activation rather than a proliferative expansion of LAK precursors . Positive_regulation IL2 TNF 3011946 59759 Tumor necrosis interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL2 TNF 3075075 104122 It was shown that *induced* [Il-2] receptor expression on CD16 ( + ) cells alone and even more in combination with Il-2 . Positive_regulation IL2 TNF 3121359 81610 Recombinant can *induce* [interleukin 2] receptor expression and cytolytic activity in a rat x mouse T cell hybrid . Positive_regulation IL2 TNF 3121359 81612 Here we show that highly purified recombinant , in combination with interleukin 2 (IL2) , can *induce* [IL2] receptor expression and cytolytic activity in a rat x mouse T cell hybrid ( PC60 ) . Positive_regulation IL2 TNF 3486658 59958 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL2 TNF 3486658 60012 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL2 TNF 3486936 60101 Tumor necrosis factor ( ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL2 TNF 3500495 80710 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL2 TNF 3526909 62651 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL2 TNF 7506142 237747 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL2 TNF 7540102 290823 Although the expressions of IL-1 beta , IL-4 , IL-5 , IL-6 , and IFN-gamma mRNA were detected in all the embryos tested , the expressions of [IL-2] , IL-3 , IFN-alpha and IFN-beta mRNA were not *detected* at all . Positive_regulation IL2 TNF 7583927 333592 In LPL , there was no SEE induced [IL-2] or IL-4 production , but IL-6 , , and gamma interferon were *induced* . Positive_regulation IL2 TNF 7583927 333610 In IEL , SEE *induced* no [IL-2] , IL-4 , or gamma interferon but produced IL-6 and TNF , while SEB stimulation resulted in no IL-2 or gamma interferon but did result in detectable IL-4 , IL-6 , and . Positive_regulation IL2 TNF 7737374 305519 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL2 TNF 7929104 274043 The addition of either or IL-2 partially *recovered* cyclosporin A-induced [IL-2R] alpha inhibition , but only TNF alpha completely recovered NF.kappa B activation . Positive_regulation IL2 TNF 8046224 266989 A single application of 30,000 U nIL-2 *induced* selective and long lasting expression of [IL-2] , IFN-gamma , and GM-CSF genes , which was not accompanied by accumulation of and IL-6 mRNAs . Positive_regulation IL2 TNF 8097322 217615 We demonstrate that IFN-gamma production from SCID splenocytes is stimulated by interleukin (IL) 12 , tumor necrosis factor alpha (TNF-alpha) , and [IL-2] but is inhibited by IL-10 , IL-10 , IL-12 , and are *induced* by heat killed Listeria monocytogenes ( hk-LM ) from SCID splenocytes and peritoneal macrophages . Positive_regulation IL2 TNF 8132326 251525 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL2 TNF 8132735 251607 Activation by [IL-2] is *dependent* on endogenous secretion of by the free cells . Positive_regulation IL2 TNF 8170078 255083 Thus , the present study failed to demonstrate the involvement of a direct action of , *activation* of immunological cells by [IL-2] or its direct action as an anti-tumor effect of intravesical instillation of BCG . Positive_regulation IL2 TNF 8207202 261384 Those results indicate that the autocrine secretion of and IL-2 , and not the primary stimulus itself , *contribute* mostly to the regulation of [IL-2R] ; Positive_regulation IL2 TNF 8230465 235830 We have recently demonstrated that tumor necrosis factor alpha (TNF-alpha) and [interleukin-2 (IL-2)] downregulate the hepatic steady-state content of hepatitis B virus ( HBV ) mRNA in vivo in HBV-transgenic mice and that the IL-2 effect is *mediated* by . Positive_regulation IL2 TNF 8302298 248786 In these transfectants , CD28 mAbs , similarly to CD3 mAbs , were able to induce Ca2+ mobilization , [IL-2] promoter *induction* ( measured as beta-galactosidase activity in T cells hybridomas pre transfected with the IL-2-lac Z reporter gene ) , IL-2 secretion , production and apoptosis ( observed as growth arrest and genome fragmentation ) . Positive_regulation IL2 TNF 8370177 229445 We show in this system that exogenously added IL-1 beta , IL-6 and *induces* IL-2 receptor (R) up-regulation and [IL-2] production , and proliferation by both CD4+ and CD8+ cells . Positive_regulation IL2 TNF 8370177 229454 These findings suggest that IL-6 and will *induce* [IL-2R] up-regulation/IL-2 secretion via the induction of IL-1 beta production . Positive_regulation IL2 TNF 8402935 230883 Pivotal *role* of endogenous in the [IL-2-driven] activation and proliferation of the functionally immature NK free subset . Positive_regulation IL2 TNF 8402948 230885 In addition , the [IL-2] production by PHA stimulated MOLT-13 and MOLT-14 cells was also *augmented* by human natural in a dose dependent manner but was inhibited by IFN-alpha even at low concentrations ( 10 IU/ml ) . Positive_regulation IL2 TNF 8409382 233333 3 ) *induces* direct thymocyte apoptosis ( a property not shared by IL-1 beta , [IL-2] , IL-4 , IL-6 and IL-7 ) . Positive_regulation IL2 TNF 8436829 213070 *Activation* of production from human neutrophils by [IL-2] via IL-2-R beta . Positive_regulation IL2 TNF 8592105 341915 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL2 TNF 8592105 341970 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL2 TNF 8910536 395212 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL2 TNF 8943722 400158 Skin cytokine patterns revealed that in normal mice , [interleukin (IL)-2] , interferon (IFN)-gamma and mRNA levels *increased* at 12 hr sensitization , whereas these cytokines were below the level of detection in CD4- mice . Positive_regulation IL2 TNF 9018238 412196 In contrast , [IL-2] *induced* significantly lower production in either cell-contact dependent or direct culture , and IL-8 and MIP-1 alpha were ineffective . Positive_regulation IL2 TNF 9346915 459567 In this cell line ( EL4D6/76 ) , *induced* ligand/receptor internalization , NFkappaB nuclear translocation , [IL-2] production , and the activation of neutral (N)-SMase and acid ( A ) -SMase . Positive_regulation IL2 TNF 9679667 520852 Transgenic expression of cytokines in beta-cells of non-diabetes-prone mice and NOD mice has suggested pathogenic roles for IFN alpha , IFN gamma , [IL-2] and IL-10 in insulin dependent diabetes mellitus ( IDDM ) development , and protective *roles* for IL-4 , IL-6 and . Positive_regulation IL2 TP63 3024966 65806 *Induction* of [interleukin 2] receptor gene expression by encoded by human T-cell leukemia virus type 1 . Positive_regulation IL20 ABCG2 20846001 2375402 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL20 CCL17 22057112 2540321 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL20 DAPK1 24220855 2897434 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL20 EPHB2 12609986 1085297 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL20 EPHB2 18310510 1904123 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL20 F3 7635444 317270 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL20 IL1B 14617515 1200642 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL20 IL1B 16375968 1547158 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL20 IL1B 17255956 1732951 [IL-20] gene expression is *induced* by through mitogen activated protein kinase and NF-kappaB dependent mechanisms . Positive_regulation IL20 IL1B 18758357 1956628 In vitro , *induced* the expression of [IL-20] . Positive_regulation IL20 IL1R2 8387521 218032 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL20 PGC 22117073 2535016 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL20 STAT4 7638186 317681 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL20 TLR7 12045249 950121 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL20 TLR7 18312842 1879410 Toxoplasma profilin is essential for host cell invasion and dependent *induction* of an [interleukin-12] response . Positive_regulation IL20 TLR7 20632067 2368007 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in mediated *activation* of caspase 1 and [interleukin-1ß] . Positive_regulation IL20 TLR7 22521509 2613569 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL20 TLR7 23246311 2732105 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL20 TNF 1463043 206762 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL20 TNF 17854477 1795893 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving dependent [interleukin-12] *induction* . Positive_regulation IL20 TNF 19830738 2168903 Like IL-22 , IL-17A and *induced* [IL-20] in keratinocytes , whereas IFN-gamma and IL-20 itself did not . Positive_regulation IL20 TNF 2113076 135548 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL20 TNF 21745554 2471919 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL20 TNF 2370931 138351 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL20 TNF 3011946 59760 interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL20 TNF 3486658 59959 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL20 TNF 3486658 60013 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL20 TNF 3486936 60102 Tumor necrosis factor ( ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL20 TNF 3500495 80711 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL20 TNF 3526909 62652 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL20 TNF 7506142 237748 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL20 TNF 7737374 305520 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL20 TNF 8132326 251526 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL20 TNF 8592105 341916 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL20 TNF 8592105 341971 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL20 TNF 8910536 395213 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL21 ABCG2 20846001 2375403 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL21 CCL17 22057112 2540322 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL21 DAPK1 24220855 2897437 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL21 EPHB2 12609986 1085298 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL21 EPHB2 18310510 1904129 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL21 F3 7635444 317273 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL21 IL1B 14617515 1200643 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL21 IL1B 16375968 1547159 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL21 IL1B 18512782 1922478 and IL-6 independently *induced* [IL-21] secretion , but the presence of IL-21 alone was not sufficient for IL-17 production . Positive_regulation IL21 IL1B 19682929 2126271 Here , we show that gammadelta T cells express IL-23R and the transcription factor RORgammat and produce IL-17 , [IL-21] , and IL-22 in *response* to and IL-23 , without T cell receptor engagement . Positive_regulation IL21 IL1R2 8387521 218034 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL21 PGC 22117073 2535017 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL21 STAT4 17548600 1752297 Here , we show that [IL-21] does not *require* to stimulate development of cytolytic activity . Positive_regulation IL21 STAT4 7638186 317682 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL21 TLR7 12045249 950122 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL21 TLR7 18312842 1879424 Toxoplasma profilin is essential for host cell invasion and dependent *induction* of an [interleukin-12] response . Positive_regulation IL21 TLR7 20632067 2368009 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in mediated *activation* of caspase 1 and [interleukin-1ß] . Positive_regulation IL21 TLR7 22521509 2613579 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL21 TLR7 23246311 2732119 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL21 TNF 1463043 206764 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL21 TNF 17854477 1795894 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving *dependent* [interleukin-12] induction . Positive_regulation IL21 TNF 2113076 135549 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL21 TNF 21745554 2471921 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL21 TNF 2370931 138352 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL21 TNF 3011946 59761 Tumor necrosis interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL21 TNF 3486658 59960 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL21 TNF 3486658 60014 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL21 TNF 3486936 60103 ( cachectin ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL21 TNF 3500495 80712 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL21 TNF 3526909 62653 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL21 TNF 7506142 237749 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL21 TNF 7737374 305521 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL21 TNF 8132326 251527 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL21 TNF 8592105 341917 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL21 TNF 8592105 341972 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL21 TNF 8910536 395214 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL21R TLR7 22530560 2686591 activation of B cells in vitro *resulted* in [IL-21R] up-regulation . Positive_regulation IL22 ABCG2 20846001 2375386 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL22 CCL17 22057112 2540305 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL22 DAPK1 24220855 2897383 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL22 EPHB2 12609986 1085281 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL22 EPHB2 18310510 1904027 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL22 F3 7635444 317136 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL22 IL1B 14617515 1200626 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL22 IL1B 16375968 1547115 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL22 IL1B 19682929 2126265 Here , we show that gammadelta T cells express IL-23R and the transcription factor RORgammat and produce IL-17 , IL-21 , and [IL-22] in *response* to and IL-23 , without T cell receptor engagement . Positive_regulation IL22 IL1B 20534450 2279258 *promoted* constitutive IL-22 secretion rather than acute [IL-22] production in response to IL-23 and induced IL-17 in some cells . Positive_regulation IL22 IL1R2 8387521 218000 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL22 JAG1 23630362 2784448 Moreover , IL-22 producing T cells were isolated from mice with experimental autoimmune uveitis , an animal model of Behçet 's disease , and the intraocular T cells from uveitis models produced large amounts of [IL-22] in the *presence* of retinal . Positive_regulation IL22 PGC 22117073 2535000 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL22 RORC 19449310 2090757 Expression of *induced* production of IL-17A , [IL-22] , IL-6 and TNF-alpha , a Th17-cell associated chemokine receptor profile and upregulation of CD161 . Positive_regulation IL22 STAT4 7638186 317665 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL22 TLR7 12045249 950052 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL22 TLR7 18312842 1879186 Toxoplasma profilin is essential for host cell invasion and dependent *induction* of an [interleukin-12] response . Positive_regulation IL22 TLR7 20632067 2367973 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in *mediated* activation of caspase 1 and [interleukin-1ß] . Positive_regulation IL22 TLR7 22306017 2560420 Flagellin induced RegIII? expression is IL-22 dependent , but how signaling *leads* to [IL-22] expression is incompletely defined . Positive_regulation IL22 TLR7 22521509 2613409 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL22 TLR7 23246311 2731881 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL22 TNF 1463043 206730 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL22 TNF 17854477 1795877 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving *dependent* [interleukin-12] induction . Positive_regulation IL22 TNF 2113076 135532 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL22 TNF 21393631 2401081 T ( h ) 22 cells produce [IL-22] in *response* to IL-6 and , particularly in the skin , whereas ?d T cells produce IL-22 in response to IL-23 , particularly in the lung . Positive_regulation IL22 TNF 21745554 2471887 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL22 TNF 22219138 2563805 These data show that blockade does not *suppress* IL-17A and [IL-22] , which can be overcome by 1,25 ( OH ) ( 2 ) D ( 3 ) . Positive_regulation IL22 TNF 2370931 138335 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL22 TNF 23781104 2820427 Freshly isolated colon infiltrating neutrophils produced IL-22 contingent upon IL-23 signaling , and [IL-22] production was *augmented* by . Positive_regulation IL22 TNF 3011946 59744 Tumor necrosis interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL22 TNF 3486658 59943 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL22 TNF 3486658 59997 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL22 TNF 3486936 60086 Tumor necrosis factor ( ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL22 TNF 3500495 80695 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL22 TNF 3526909 62636 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL22 TNF 7506142 237732 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL22 TNF 7737374 305504 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL22 TNF 8132326 251510 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL22 TNF 8592105 341900 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL22 TNF 8592105 341955 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL22 TNF 8910536 395196 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL23A CD14 15516327 1328550 LPS induced increase of [IL-23] and IL-12 subunits expression was *dependent* , while CD14 was not involved in SAC induced p19 transcription . Positive_regulation IL23A EPHB2 15626475 1362098 differentially *regulate* expression of [IL-23 p19] compared with p40 and IFN-beta in Theiler 's virus infected RAW264.7 cells . Positive_regulation IL23A IL1B 16622035 1551578 further *increased* the production of [IL-23] , which induced IL-17 production and OX40 expression in splenic CD4 ( + ) T cells of IL-1Ra ( -/- ) mice . Positive_regulation IL23A IL1B 17569750 1774230 *regulates* [IL-23 p19] expression via NF-kappaB and AP-1 pathways . Positive_regulation IL23A IL1B 18390747 1893324 IL-17A , IL-17F , and [IL-23] could *induce* the release of chemokines GRO-alpha/CXCL1 , IL-8/CXCL8 , and MIP-1beta/CCL4 from eosinophils , while IL-17F and IL-23 could also increase the production of proinflammatory cytokines and IL-6 . Positive_regulation IL23A IL1B 18802048 1964476 Moreover , alone *triggered* [IL-23] secretion and the IL-1R antagonist inhibited this response in PBMC and purified monocytes . Positive_regulation IL23A IL1B 19201028 2061370 In contrast , *mediated* induction of [IL-23 p19] expression was cell-specific . Positive_regulation IL23A IL1B 19201028 2061371 *Induction* of [IL-23 p19] expression by was present in FLS but almost absent in the DF derived from the same patients . Positive_regulation IL23A PTGER2 15486065 1366916 Interestingly , the reciprocal regulation of IL-12/IL-27 and [IL-23] by ATP was mediated by 2 distinct P2 receptors and was also *induced* by prostaglandin E ( 2 ) by cyclic adenosine monophosphate ( cAMP ) -elevating receptors . Positive_regulation IL23A TLR7 17182554 1679773 Essential roles of c-Rel in *induced* [IL-23 p19] gene expression in dendritic cells . Positive_regulation IL23A TLR7 17475882 1738476 MyD88-/- mice were used to assess E. faecalis/E. coli induced *dependent* signaling and [IL-23] gene expression . Positive_regulation IL23A TLR7 17897860 1811287 TLR3 and are *involved* in expression of [IL-23] subunits while TLR3 but not TLR7 is involved in expression of IFN-beta by Theiler 's virus infected RAW264.7 cells . Positive_regulation IL23A TLR7 17897860 1811299 Thus TLR3 and *contribute* to TMEV induced [IL-23 p19] and p40 , while TLR3 contributes to TMEV induced IFN-beta . Positive_regulation IL23A TLR7 17919942 1819496 MDP enhanced obligate bacterial agonist *induction* of [IL-23] and IL-1 , which promoted IL-17 expression in T cells . Positive_regulation IL23A TLR7 18276743 2010178 *dependent* induction of p19 , p40 and bioactive [IL23] was determined in RA synovial fibroblasts ( RASF ) , monocytes and monocyte derived dendritic cells ( MDDCs ) by real-time PCR and reverse transcriptase ( RT ) -PCR , Western blot and functional assays . Positive_regulation IL23A TLR7 18802116 1964970 Notably , [IL-23] production in *response* to single ligands was inhibited by IL-4 . Positive_regulation IL23A TLR7 20408896 2300606 In the present study , we examined the effect of prostaglandin E ( 2 ) ( PGE ( 2 ) ) treatment of DCs during differentiation on IL-12 and [IL-23] production in *response* to stimulation . Positive_regulation IL23A TLR7 20483758 2270102 Human intestinal lamina propria CD1c+ dendritic cells display an activated phenotype at steady state and produce [IL-23] in *response* to stimulation . Positive_regulation IL23A TLR7 22559913 2719158 While C5a indeed enhanced cytokine production of immature DCs , the addition of C5a inhibited production of IL-12 , [IL-23] and TNFa *induced* by various ligands such as LPS , R848 and Pam ( 3 ) CSK ( 4 ) . Positive_regulation IL23A TLR7 22649103 2620314 First , costimulation strongly *increased* transcription of pro-IL-1ß and [IL-23p19] . Positive_regulation IL23A TLR7 22777843 2682025 Although RNA could also induce moderate *dependent* [IL-23] and tumor necrosis factor-alpha ( TNF-a ) secretion , TLR7 and other endosomal TLRs were redundant for IL-23 or TNF-a induction by whole fungi . Positive_regulation IL23A TLR7 22896020 2677816 The combination of ligands for and TLR3 *led* to synergistic secretion of both [IL-23] and IL-12p70 from all subjects ; Positive_regulation IL23A TLR7 22896633 2666463 p38 MAPK activation and IL-12p70 production was more robust from TFF2 ( -/- ) CD8+ DC compared with WT CD8+ DC and treatment of WT DC with rTFF2 suppressed *induced* [IL-12/23p40] production . Positive_regulation IL23A TLR7 23080298 2745152 KCs lacking Tpl2 display defects with *induction* of cytokines interleukin (IL)-1ß , IL-10 , and [IL-23] . Positive_regulation IL23A TLR7 23755218 2797747 The aim of our study was to define the relative contribution of age and clinical status on *induced* interleukin (IL)-12p70 and [IL-23] production as these cytokines play an important role in the protection against intracellular and extracellular pathogens , respectively . Positive_regulation IL23A TNF 17619881 1815991 *induced* MIP-3alpha but not [IL-23] production in cultured synovial cells from RA patients . Positive_regulation IL23A TNF 20428758 2247271 [IL-23] , which constitutively expressed in oral cancer , was *enhanced* by and IL-23 . Positive_regulation IL23A TNF 21472205 2361544 IL-23 and its receptor mRNAs and proteins were spontaneously expressed , and [IL-23] was *increased* by stimulation in the oral cancer cells . Positive_regulation IL23A TNF 21682792 2524002 Release of IL-6 and [IL-23] was *enhanced* less than twofold by the addition of AF while production was unchanged . Positive_regulation IL24 ABCG2 20846001 2375383 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL24 CCL17 22057112 2540303 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL24 DAPK1 24220855 2897377 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL24 EPHB2 12609986 1085279 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL24 EPHB2 18310510 1904015 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL24 F3 7635444 317130 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL24 FAS 19417161 2179818 Our data show that in kidney cancer cells [GST-MDA-7] *induces* ceramide dependent activation of , which is causal in promoting an endoplasmic reticulum stress response that activates multiple proapoptotic pathways to decrease survival . Positive_regulation IL24 IL1B 14617515 1200624 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL24 IL1B 16375968 1547113 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL24 IL1B 19535621 2098898 The *induced* [IL-24] mRNA expression was mediated by the activation of the transcription factors , AP-1 and C/EBP-beta . Positive_regulation IL24 IL1R2 8387521 217996 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL24 MMP7 24270662 2926661 [IL-24] *induced* the expression of in SCC cells in culture . Positive_regulation IL24 PGC 22117073 2534998 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL24 STAT4 7638186 317636 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL24 TLR7 12045249 950050 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL24 TLR7 18312842 1879158 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Positive_regulation IL24 TLR7 20632067 2367969 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in *mediated* activation of caspase 1 and [interleukin-1ß] . Positive_regulation IL24 TLR7 22521509 2613389 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL24 TLR7 23246311 2731853 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL24 TNF 1463043 206726 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL24 TNF 17854477 1795875 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving *dependent* [interleukin-12] induction . Positive_regulation IL24 TNF 2113076 135503 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL24 TNF 21593768 2454126 GW9508 further suppressed expression of IL-11 , [IL-24] , and IL-33 *induced* in HaCaT cells by and IFN-? . Positive_regulation IL24 TNF 21745554 2471882 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL24 TNF 2370931 138333 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL24 TNF 24211183 2868571 Here we report that the development of psoriasis-like skin inflammation in mice with epidermis-specific inhibition of the transcription factor NF-?B was triggered by *dependent* upregulation of [interleukin-24 (IL-24)] and activation of signal transducer and activator of transcription 3 ( STAT3 ) signaling in keratinocytes . Positive_regulation IL24 TNF 3011946 59715 interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL24 TNF 3486658 59941 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL24 TNF 3486658 59995 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL24 TNF 3486936 60057 ( cachectin ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL24 TNF 3500495 80693 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL24 TNF 3526909 62607 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL24 TNF 7506142 237730 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL24 TNF 7737374 305502 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL24 TNF 8132326 251481 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL24 TNF 8592105 341898 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL24 TNF 8592105 341926 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL24 TNF 8910536 395194 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL25 ABCG2 20846001 2375385 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL25 CCL17 22057112 2540304 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL25 DAPK1 24220855 2897380 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL25 EPHB2 12609986 1085280 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL25 EPHB2 18310510 1904021 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL25 F3 7635444 317133 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL25 IL1B 14617515 1200625 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL25 IL1B 16375968 1547114 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL25 IL1R2 8387521 217998 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL25 PGC 22117073 2534999 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL25 STAT4 7638186 317664 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL25 TLR7 12045249 950051 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL25 TLR7 18312842 1879172 Toxoplasma profilin is essential for host cell invasion and dependent *induction* of an [interleukin-12] response . Positive_regulation IL25 TLR7 20632067 2367971 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in *mediated* activation of caspase 1 and [interleukin-1ß] . Positive_regulation IL25 TLR7 22521509 2613399 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL25 TLR7 23246311 2731867 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL25 TNF 1463043 206728 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL25 TNF 17854477 1795876 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving dependent [interleukin-12] *induction* . Positive_regulation IL25 TNF 20944558 2389298 [Interleukin-25] production is differently *regulated* by and TGF-ß1 in the human gut . Positive_regulation IL25 TNF 20944558 2389302 Consistently , [IL-25] production was *enhanced* by both in vitro and in vivo . Positive_regulation IL25 TNF 20944558 2389304 Data show that [IL-25] production is differently *regulated* by and TGF-ß1 in the human gut . Positive_regulation IL25 TNF 2113076 135531 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL25 TNF 21745554 2471885 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL25 TNF 2370931 138334 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL25 TNF 3011946 59743 interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL25 TNF 3486658 59942 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL25 TNF 3486658 59996 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL25 TNF 3486936 60085 ( cachectin ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL25 TNF 3500495 80694 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL25 TNF 3526909 62635 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL25 TNF 7506142 237731 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL25 TNF 7737374 305503 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL25 TNF 8132326 251509 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL25 TNF 8592105 341899 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL25 TNF 8592105 341954 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL25 TNF 8910536 395195 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL26 ABCG2 20846001 2375390 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL26 CCL17 22057112 2540309 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL26 DAPK1 24220855 2897398 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL26 EPHB2 12609986 1085285 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL26 EPHB2 18310510 1904051 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL26 F3 7635444 317176 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL26 IL1B 14617515 1200630 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL26 IL1B 16375968 1547119 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL26 IL1R2 8387521 218008 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL26 PGC 22117073 2535004 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL26 STAT4 7638186 317669 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL26 TLR7 12045249 950096 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL26 TLR7 18312842 1879242 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Positive_regulation IL26 TLR7 20632067 2367983 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in mediated *activation* of caspase 1 and [interleukin-1ß] . Positive_regulation IL26 TLR7 22521509 2613449 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL26 TLR7 23246311 2731937 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL26 TNF 1463043 206738 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL26 TNF 17854477 1795881 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving dependent [interleukin-12] *induction* . Positive_regulation IL26 TNF 2113076 135536 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL26 TNF 21745554 2471895 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL26 TNF 2370931 138339 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL26 TNF 3011946 59748 Tumor necrosis interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL26 TNF 3486658 59947 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL26 TNF 3486658 60001 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL26 TNF 3486936 60090 Tumor necrosis factor ( ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL26 TNF 3500495 80699 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL26 TNF 3526909 62640 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL26 TNF 7506142 237736 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL26 TNF 7737374 305508 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL26 TNF 8132326 251514 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL26 TNF 8592105 341904 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL26 TNF 8592105 341959 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL26 TNF 8910536 395200 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL27 ABCG2 20846001 2375391 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL27 CCL17 22057112 2540310 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL27 DAPK1 24220855 2897401 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL27 EPHB2 12609986 1085286 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL27 EPHB2 18310510 1904057 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL27 F3 7635444 317179 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL27 IL1B 14617515 1200631 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL27 IL1B 16375968 1547120 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL27 IL1R2 8387521 218010 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL27 PGC 22117073 2535005 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL27 STAT4 7638186 317670 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL27 TLR7 12045249 950097 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL27 TLR7 18312842 1879256 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Positive_regulation IL27 TLR7 20632067 2367985 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in mediated *activation* of caspase 1 and [interleukin-1ß] . Positive_regulation IL27 TLR7 22521509 2613459 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL27 TLR7 23246311 2731951 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL27 TNF 1463043 206740 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL27 TNF 17854477 1795882 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving *dependent* [interleukin-12] induction . Positive_regulation IL27 TNF 2113076 135537 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL27 TNF 21745554 2471897 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL27 TNF 2370931 138340 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL27 TNF 2813400 121480 *stimulated* the phosphorylation of a 28-kDa protein ( [p28] ) in the ME-180 line of human cervical carcinoma cells . Positive_regulation IL27 TNF 2813400 121481 The specific binding of 125I labeled TNF-alpha to cell-surface binding sites , the *stimulation* of [p28] phosphorylation by , and the inhibition of cell proliferation by TNF-alpha occurred with nearly identical dose-response relationships . Positive_regulation IL27 TNF 3011946 59749 interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL27 TNF 3486658 59948 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL27 TNF 3486658 60002 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL27 TNF 3486936 60091 ( cachectin ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL27 TNF 3500495 80700 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL27 TNF 3526909 62641 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL27 TNF 7506142 237737 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL27 TNF 7737374 305509 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL27 TNF 8132326 251515 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL27 TNF 8592105 341905 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL27 TNF 8592105 341960 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL27 TNF 8910536 395201 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL27RA TNF 15749890 1379732 In the absence of [WSX-1] , an increased production of the proinflammatory cytokines and IL-12p40 *resulted* in elevated CD4+ T cell activation and IFN-gamma production , which enhanced macrophage effector functions and reduced bacterial loads . Positive_regulation IL2RA EPHB2 23586039 2768727 Either using PD98059 ( a specific inhibitor for p-ERK ) or depletion of with small interfering RNA ( siRNA ) *reduced* the expression of [CD25] . Positive_regulation IL2RA IL1B 9402849 469567 Thus , circulating could be *involved* in the expression of [CD25] on CD4+ T-PBL and favors the generation of memory CD4+ T-PBL . Positive_regulation IL2RA IL6R 16540526 1537058 Differential expression of and CD130 *mediates* different STAT-3 phosphorylation in [CD4+CD25-] and CD25high regulatory T cells . Positive_regulation IL2RA NEDD9 7905283 240313 Partial inhibition of p50 and expression by NF-kappa B1 antisense oligonucleotides significantly *reduced* T-cell proliferation and [CD25/IL-2R] alpha cell surface expression . Positive_regulation IL2RA STAT4 14660657 1202293 Thus , these results provide a model for *dependent* gene induction and a mechanism for cytokine induced expression of the [CD25] gene . Positive_regulation IL2RA STAT4 22888135 2666238 The cytokines act ex vivo to increase [CD25] levels , and IL-12 , IL-12R , and , but not the NK activating receptor Ly49H , are *required* for peak induction in vivo . Positive_regulation IL2RA TCN1 21092462 2350040 to study the change of airway inflammation *induced* by and the expression of CD4 ( + ) [CD25] ( + ) regulatory T cells ( Treg ) in smoking cessation rats . Positive_regulation IL2RA TLR7 15096475 1244274 Both and inflammatory cytokines *induced* the expression of [CD25] , CD69 , CD80 and , surprisingly , also of CD83 , commonly regarded as an activation marker for mature dendritic cells ( DC ) . Positive_regulation IL2RA TNF 12014650 941640 In contrast , during the 18- to 36-hours interval , *induced* significantly higher ( p < 0.05 ) leukoctyte , T cell , and NK cell numbers , basal leukocyte proliferation , and [CD25+] activation marker expression ; Positive_regulation IL2RA TNF 16647464 1553187 stimulation and TCR/CD28 co-stimulation significantly *increased* EC ICAM-1/VCAM-1-expression and LC [CD25] surface expression , respectively . Positive_regulation IL2RA TNF 2318252 130248 By contrast , strongly *increased* the membrane level of [CD25] and to a lesser extent that of the activation antigen , 4F2 , over the levels already induced by phorbol esters on T cells . Positive_regulation IL2RA TNF 2407536 130397 In accordance with these observations , IL6 and to a lesser extent were found to *enhance* [IL2R] expression by CD8 cells . Positive_regulation IL2RA TNF 3045826 97126 Immunofluorescence analysis revealed that selectively *up-regulated* [Tac antigen] expression on LAK precursors . Positive_regulation IL2RA TNF 8370177 229447 We show in this system that exogenously added IL-1 beta , IL-6 and *induces* [IL-2 receptor (R)] up-regulation and IL-2 production , and proliferation by both CD4+ and CD8+ cells . Positive_regulation IL2RA TNF 8977306 403219 Furthermore , IL-12 up-regulated TNF receptors on gammadelta T cells in vitro : binding to its receptor *induced* [CD25] expression on the gammadelta T cells in an autocrine or paracrine fashion , or perhaps both . Positive_regulation IL2RB EPHB2 24026251 2846122 These data suggest that ethanol increases p75NTR expression , and CK2 and signaling inversely *regulate* Sp1 mediated [p75NTR] expression in ethanol treated neuroblastoma cells . Positive_regulation IL2RB TNF 10414455 631052 Human binds to and *activates* the murine p55 receptor , but not the [p75] receptor . Positive_regulation IL2RB TNF 19559672 2110575 *augmented* the IL-15 induced expression of NK1 .1 and [CD122] in mature NK cells , and TNF-alpha alone also induced NK cell maturation as well as IL-15 . Positive_regulation IL2RB TNF 8370177 229449 We show in this system that exogenously added IL-1 beta , IL-6 and *induces* [IL-2 receptor (R)] up-regulation and IL-2 production , and proliferation by both CD4+ and CD8+ cells . Positive_regulation IL2RG CAPN8 9326644 457215 Together , these data suggest that *mediated* cleavage of [gammac] represents a mechanism by which gammac dependent signaling can be controlled . Positive_regulation IL2RG IL1B 11394690 823250 Low levels of [gammaC] transcript were detectable in unstimulated macrophage cultures and expression was *increased* by stimulation of the cells with recombinant trout or LPS . Positive_regulation IL2RG IL1B 11394690 823251 Similarly , in the RTG cell line which exhibited even lower level constitutive expression , stimulation with *increased* [gammaC] transcript levels but LPS had no effect . Positive_regulation IL2RG TGM2 16382148 1505651 Here , we report that the Ca2+ dependent protein cross linking enzyme is *involved* in THG induced p40 and [p64] formation by catalyzing caspase 3 cross linking reactions , thereby inactivating caspase 3 and apoptosis in Bax-deficient cells . Positive_regulation IL2RG TNF 8370177 229451 We show in this system that exogenously added IL-1 beta , IL-6 and *induces* [IL-2 receptor (R)] up-regulation and IL-2 production , and proliferation by both CD4+ and CD8+ cells . Positive_regulation IL3 ABCG2 20846001 2375404 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL3 CCL17 22057112 2540323 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL3 DAPK1 24220855 2897440 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL3 EPHB2 10586114 571866 Despite the fact that [IL-3] did *induce* p38 and kinase activity , it was not able to enhance IL-6 protein secretion , which coincided with the inability of IL-3 to induce NFkappaB ( nuclear factor kappaB ) activation and IkappaB ( inhibitory protein kappaB ) degradation . Positive_regulation IL3 EPHB2 10702314 672663 Granulocyte/macrophage colony stimulating factor , [interleukin 3] , and TPA , all of which induced macrophage proliferation , also *induced* activity , which was maximal at 5 min poststimulation . Positive_regulation IL3 EPHB2 12609986 1085299 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL3 EPHB2 18310510 1904135 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL3 EPHB2 9533450 496954 However , the production of [IL-3] and IL-4 was only partially *dependent* upon activation , whereas IL-5 , IL-10 , IFN-gamma and GM-CSF production was severely affected by diminished ERK activation . Positive_regulation IL3 F3 7635444 317276 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL3 ID1 15905544 1409382 expression can be *induced* by [IL-3] in HSC during myeloid differentiation , but not by growth factors that promote erythroid and B cell development . Positive_regulation IL3 ID1 21732357 2538870 Importantly , [IL-3] *induced* inhibitor of DNA binding/differentiation ( in hBMMs , while Id2 were sustained during osteoclast differentiation of mBMMs treated with IL-3 . Positive_regulation IL3 IL1B 10607313 575172 No [IL-3] was *detected* , while , IL-2 , IL-4 , IL-10 and GM-CSF were variably expressed . Positive_regulation IL3 IL1B 14617515 1200644 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL3 IL1B 16375968 1547160 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL3 IL1B 7540102 290827 Although the expressions of , IL-4 , IL-5 , IL-6 , TNF-alpha and IFN-gamma mRNA were detected in all the embryos tested , the expressions of IL-2 , [IL-3] , IFN-alpha and IFN-beta mRNA were not *detected* at all . Positive_regulation IL3 IL1B 8862438 388671 Furthermore , *induced* increased [IL-3] and GM-CSF mRNA expression in hematopoietic cells but induced decreased macrophage inflammatory protein 1 alpha ( MIP1 alpha ) mRNA expression as compared with SCF+IL-1 beta +IL-3 . Positive_regulation IL3 IL1B 9053967 345089 Although and IFN-gamma mRNA were detected in most specimens , IL-2 , [IL-3] , IL-4 , IL-5 , IL-9 , TNF-alpha , and IFN-beta mRNA were not *detected* at all . Positive_regulation IL3 IL1R2 8387521 218036 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL3 PECAM1 12935294 1157805 We have identified the inhibitory immunoreceptor PECAM-1 ( platelet endothelial cell adhesion molecule-1 ) /CD31 ( cluster determinant 31 ) as a component of this 135 kDa substrate and also show that [IL-3] can *induce* tyrosine phosphorylation of . Positive_regulation IL3 PGC 22117073 2535018 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL3 STAT4 7638186 317683 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL3 STAT4 7760829 308018 In contrast , IL-2 , [IL-3] , and erythropoietin *induce* the tyrosine phosphorylation of Stat5 while IL-12 uniquely induces the tyrosine phosphorylation of . Positive_regulation IL3 TLR7 12045249 950123 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL3 TLR7 18312842 1879438 Toxoplasma profilin is essential for host cell invasion and dependent *induction* of an [interleukin-12] response . Positive_regulation IL3 TLR7 20632067 2368011 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in mediated *activation* of caspase 1 and [interleukin-1ß] . Positive_regulation IL3 TLR7 22521509 2613589 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL3 TLR7 23246311 2732133 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL3 TNF 1463043 206766 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL3 TNF 1531845 180413 again , IL-1 , IL-2 , , and IFN-gamma mRNA were abundant , but in addition , [IL-3] , IL-6 , and granulocyte-macrophage colony stimulating factor mRNA were greatly *increased* , suggesting an important role in the recall response . Positive_regulation IL3 TNF 15381112 1298608 ERBA did not affect IL-2- , [IL-3-] , and GCSF dependent cell growth , or alpha *induced* growth suppression , nor did ERBA affect osteoclast formation induced by IL-11 , leukemia inhibitory factor , and 1alpha,25-dihydroxyvitamin D ( 3 ) . Positive_regulation IL3 TNF 16455967 1522317 We have found that [IL-3] stimulation of bone marrow cells *induces* the production of via a PI3K- and MAPK kinase/ERK dependent pathway . Positive_regulation IL3 TNF 17854477 1795895 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving dependent [interleukin-12] *induction* . Positive_regulation IL3 TNF 18760623 1975412 After 48 h , also induced a significant *increase* in IL-1beta , [IL-3] , and IP-10 secretion . Positive_regulation IL3 TNF 1885210 165699 [Interleukin-3] at the concentration used ( i.e. , 100 U/ml ) did not *induce* the production of any cytokines , whereas it enhanced significantly the secretion of IL-1 , IL-6 and by LPS stimulated macrophages . Positive_regulation IL3 TNF 2113076 135550 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL3 TNF 21745554 2471923 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL3 TNF 2364439 136668 Kinetic studies of IL-1 induced IL-3 production indicated that 4-6 days of culture were required for optimal production , whereas 1-2 days were sufficient in cultures stimulated with concanavalin A. Recombinant IL-6 failed to induce significant amounts of IL-3 , and *induced* only weak [IL-3] production . Positive_regulation IL3 TNF 2370931 138353 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL3 TNF 3011946 59762 Tumor necrosis interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL3 TNF 3486658 59961 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL3 TNF 3486658 60015 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL3 TNF 3486936 60104 Tumor necrosis factor ( ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL3 TNF 3500495 80713 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL3 TNF 3526909 62654 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL3 TNF 7506142 237750 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL3 TNF 7540102 290826 Although the expressions of IL-1 beta , IL-4 , IL-5 , IL-6 , and IFN-gamma mRNA were detected in all the embryos tested , the expressions of IL-2 , [IL-3] , IFN-alpha and IFN-beta mRNA were not *detected* at all . Positive_regulation IL3 TNF 7545455 318547 alpha *induced* up-regulation of [interleukin-3] receptor mRNA expression in a CD34 positive hematopoietic cell line . Positive_regulation IL3 TNF 7737374 305522 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL3 TNF 8132326 251528 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL3 TNF 8592105 341918 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL3 TNF 8592105 341973 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL3 TNF 8656685 364763 [IL-3] , IL-10 , IL-11 , insulin-like growth factor-I and also *stimulated* DNA synthesis in all three cell lines ; Positive_regulation IL3 TNF 8910536 395215 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL3 TNF 9122614 423986 *regulates* GM-CSF- , [IL-3-] or M-CSF induced Fc epsilon RII/CD23 gene expression and soluble Fc epsilon RII release by human monocytes . Positive_regulation IL3 TNS1 7566975 328512 [IL-3] *induced* a transient association between paxillin and vinculin , while in BCR/ABL transformed cells , several proteins coimmunoprecipitated with paxillin , including vinculin , p125FAK , talin and . Positive_regulation IL31 ABCG2 20846001 2375392 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL31 CCL17 22057112 2540311 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL31 DAPK1 24220855 2897404 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL31 EPHB2 12609986 1085287 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL31 EPHB2 18310510 1904063 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL31 F3 7635444 317182 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL31 IL1B 14617515 1200632 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL31 IL1B 16375968 1547121 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL31 IL1R2 8387521 218012 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL31 PGC 22117073 2535006 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL31 STAT4 7638186 317671 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL31 TLR7 12045249 950098 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL31 TLR7 18312842 1879270 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Positive_regulation IL31 TLR7 20632067 2367987 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in mediated *activation* of caspase 1 and [interleukin-1ß] . Positive_regulation IL31 TLR7 22521509 2613469 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL31 TLR7 23246311 2731965 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL31 TNF 1463043 206742 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL31 TNF 17854477 1795883 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving dependent [interleukin-12] *induction* . Positive_regulation IL31 TNF 2113076 135538 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL31 TNF 21745554 2471899 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL31 TNF 2370931 138341 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL31 TNF 3011946 59750 Tumor necrosis interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL31 TNF 3486658 59949 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL31 TNF 3486658 60003 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL31 TNF 3486936 60092 Tumor necrosis factor ( ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL31 TNF 3500495 80701 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL31 TNF 3526909 62642 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL31 TNF 7506142 237738 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL31 TNF 7737374 305510 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL31 TNF 8132326 251516 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL31 TNF 8592105 341906 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL31 TNF 8592105 341961 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL31 TNF 8910536 395202 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL32 ABCG2 20846001 2375389 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL32 CCL17 22057112 2540308 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL32 DAPK1 24220855 2897395 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL32 EPHB2 12609986 1085284 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL32 EPHB2 18310510 1904045 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL32 F3 7635444 317173 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL32 IL1B 14617515 1200629 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL32 IL1B 16375968 1547118 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL32 IL1B 17590175 1779197 [IL-32alpha] *induction* by and/or TNF-alpha was mediated by NF-kappaB activation . Positive_regulation IL32 IL1B 18239058 1877010 , IFN-gamma , and TNF-alpha *enhanced* intracellular accumulation of [IL-32alpha] protein , but IL-32alpha was not detected in supernatants . Positive_regulation IL32 IL1B 18239058 1877023 Human pancreatic periacinar myofibroblasts expressed [IL-32alpha] in *response* to , TNF-alpha , and IFN-gamma . Positive_regulation IL32 IL1B 19228941 2044729 At concentrations as low as 0.1 ng/ml , *stimulated* [IL-32] up to 15-fold over constitutive levels , whereas 10 ng/ml of TNFalpha or 100 ng/ml of lipopolysaccharide (LPS) were required to induce similar quantities of IL-32 . Positive_regulation IL32 IL1B 19228941 2044730 *induced* [IL-32] was reduced by inhibition of the IkappaB kinase-beta/NF-kappaB and ERK pathways . Positive_regulation IL32 IL1B 20480520 2263256 Butyrate also up-regulated *induced* [IL-32alpha] mRNA expression . Positive_regulation IL32 IL1B 20480520 2263257 Like butyrate , trichostatin A , a histone deacetylase inhibitor , also enhanced *induced* [IL-32alpha] mRNA expression . Positive_regulation IL32 IL1R2 8387521 218006 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL32 ITGB2 24295830 2926693 Moreover , [IL-32?] and iE-DAP or MDP *induced* the significant up-regulation of the cell-surface expression of adhesion molecule and ICAM-1 on eosinophils . Positive_regulation IL32 MAP2K6 22413812 2600517 The H2O2 augmented IFN? induced [IL-32] mRNA expression was *suppressed* by a JNK inhibitor , but not by inhibitor , p38 inhibitor , and JAK inhibitor I. Significant binding of c-Jun and CREB to the IL-32 promoter was observed in the IFN? + H2O2 stimulated HBE cells . Positive_regulation IL32 PGC 22117073 2535003 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL32 STAT4 7638186 317668 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL32 TLR7 12045249 950095 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL32 TLR7 18312842 1879228 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Positive_regulation IL32 TLR7 20632067 2367981 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in mediated *activation* of caspase 1 and [interleukin-1ß] . Positive_regulation IL32 TLR7 22521509 2613439 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL32 TLR7 23246311 2731923 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL32 TLR7 23534905 2777571 *mediated* induction of proinflammatory cytokine [IL-32] in corneal epithelium . Positive_regulation IL32 TLR7 23534905 2777581 This study was to explore mediated *induction* of [IL-32] and the inflammatory effects of IL-32 in corneal epithelium . Positive_regulation IL32 TNF 1463043 206736 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL32 TNF 15664165 1365195 Although IL-32 does not share sequence homology with known cytokine families , [IL-32] *induces* various cytokines , human , and IL-8 in THP-1 monocytic cells as well as mouse TNFalpha and MIP-2 in Raw macrophage cells . Positive_regulation IL32 TNF 17078892 1663553 Interestingly , reciprocally *induced* [IL-32] mRNA expression in T cells , monocyte derived dendritic cells , and synovial fibroblasts . Positive_regulation IL32 TNF 17590175 1779196 [IL-32alpha] *induction* by IL-1beta and/or was mediated by NF-kappaB activation . Positive_regulation IL32 TNF 17854477 1795880 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving *dependent* [interleukin-12] induction . Positive_regulation IL32 TNF 18239058 1877008 IL-1beta , IFN-gamma , and *enhanced* intracellular accumulation of [IL-32alpha] protein , but IL-32alpha was not detected in supernatants . Positive_regulation IL32 TNF 18239058 1877011 An inhibitor of phosphatidylinositol 3-kinase ( LY294002 ) significantly suppressed IL-1beta- , IFN-gamma- , and *induced* [IL-32alpha] mRNA expression , although MAPK inhibitors had no effect . Positive_regulation IL32 TNF 18239058 1877021 Blockade of NF-kappaB and AP-1 activation by an adenovirus expressing a stable mutant form of IkappaBalpha and a dominant negative mutant of c-Jun markedly suppressed IL-1beta- , IFN-gamma- , and/or *induced* [IL-32alpha] mRNA expression . Positive_regulation IL32 TNF 19248119 2045074 *induced* expression of [IL-32] was significantly suppressed , in a dose dependent manner , by inhibitors of Syk , protein kinase Cdelta (PKCdelta) , and JNK and by knockdown of these kinases and c-Jun with siRNA . Positive_regulation IL32 TNF 19386602 2094833 An inhibitor of phosphatidylinositol 3-kinase ( LY294002 ) significantly suppressed the IL-1beta- , IFN-gamma- and *induced* [IL-32] mRNA expression . Positive_regulation IL32 TNF 19386602 2094838 The blockade of NF-kappaB and activated protein-1 activation markedly suppressed the IL-1beta- , IFN-gamma- , and/or *induced* [IL-32] mRNA expression . Positive_regulation IL32 TNF 20541181 2284782 In this study , we elucidated the role of human *inducing* factor , [Interleukin-32 (IL-32)] , in porcine kidney cells ( PK-15 ) during cell mediated rejection by examining host cell responses . Positive_regulation IL32 TNF 20615213 2321724 The [IL-32a] isoform was expressed intracellularly in *response* to and poly I:C and not released in culture supernatants . Positive_regulation IL32 TNF 20615213 2321728 Stimulation of FLS with , BLP , lipopolysaccharide , or poly I:C concomitant with IFN-? *increased* [IL-32] expression compared with stimulation with IFN-? alone . Positive_regulation IL32 TNF 20615213 2321731 Thus , IFN-? , double-strand RNA , hyaluronic acid , or other damage associated molecular patterns ( DAMPs ) , highly secreted in synovial tissues of RA patients , might *trigger* [IL-32] secretion by FLSs . Positive_regulation IL32 TNF 2113076 135535 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL32 TNF 21152864 2373362 An inhibitor of phosphatidylinositol 3-kinase ( LY294002 ) significantly suppressed IL-1ß- and *induced* [IL-32a] mRNA expression , although MAPK inhibitors had no effect . Positive_regulation IL32 TNF 21152864 2373367 Blockade of NF-?B activation by an adenovirus expressing a stable mutant form of I?Ba markedly suppressed IL-1ß- and *induced* [IL-32a] mRNA expression . Positive_regulation IL32 TNF 21152864 2373368 Human colonic SEMFs expressed [IL-32a] in *response* to IL-1ß and . Positive_regulation IL32 TNF 21346229 2404111 Several studies have documented a proinflammatory role for [IL-32] , which *induces* IL-1a , IL-1ß , IL-6 , , and chemokines via NF-?B , p38MAPK , and AP-1 . Positive_regulation IL32 TNF 21381070 2431811 In vitro , IL-1ß and significantly *induced* [IL-32] expression in human Huh-7.5 cells . Positive_regulation IL32 TNF 21381070 2431827 However , IFN-a exerted a significant additive effect on *induced* but not IL-1ß induced [IL-32] expression , particularly in CD14+ monocytes . Positive_regulation IL32 TNF 21745554 2471893 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL32 TNF 21899560 2524732 Production of [IL-32] was *induced* by IFN-? , , and dsRNA in primary airway epithelial cells . Positive_regulation IL32 TNF 22336080 2576429 [IL-32] is *induced* by IFN-? , , T(H)1 cells , and rhinovirus in bronchial epithelial cells . Positive_regulation IL32 TNF 22486709 2595431 The *induction* of [IL-32] by , IFN-? and Th1 cells as well as its increased expression in sinus tissues from CRS patients with nasal polyps demonstrated a potential role for IL-32 in the pathogenesis of CRS . Positive_regulation IL32 TNF 23242112 2718616 [IL-32] was *induced* by IFN-? , , dsRNA , and incubation with Th1 cells in primary nasal epithelial cells . Positive_regulation IL32 TNF 2370931 138338 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL32 TNF 3011946 59747 interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL32 TNF 3486658 59946 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL32 TNF 3486658 60000 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL32 TNF 3486936 60089 ( cachectin ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL32 TNF 3500495 80698 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL32 TNF 3526909 62639 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL32 TNF 7506142 237735 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL32 TNF 7737374 305507 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL32 TNF 8132326 251513 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL32 TNF 8592105 341903 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL32 TNF 8592105 341958 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL32 TNF 8910536 395199 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL33 ABCG2 20846001 2375388 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL33 CCL17 22057112 2540307 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL33 DAPK1 24220855 2897389 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL33 EPHB2 12609986 1085283 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL33 EPHB2 18310510 1904039 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL33 F3 7635444 317170 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL33 IL1B 14617515 1200628 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL33 IL1B 16375968 1547117 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL33 IL1B 18023358 1832121 In addition , [IL-33] also *induced* , TNF-alpha , MCP-1 , and PGD2 production in BMMC . Positive_regulation IL33 IL1B 19248109 2045069 In cultured synovial fibroblasts , [IL-33] expression was strongly *induced* by and/or tumor necrosis factor alpha . Positive_regulation IL33 IL1R2 8387521 218004 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL33 PGC 22117073 2535002 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL33 STAT4 7638186 317667 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL33 TLR7 12045249 950094 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL33 TLR7 18312842 1879214 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Positive_regulation IL33 TLR7 20632067 2367979 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in mediated *activation* of caspase 1 and [interleukin-1ß] . Positive_regulation IL33 TLR7 21684348 2460344 *mediated* induction of pro-allergic cytokine [IL-33] in ocular mucosal epithelium . Positive_regulation IL33 TLR7 22521509 2613429 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL33 TLR7 23246311 2731909 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL33 TNF 1463043 206734 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL33 TNF 17854477 1795879 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving dependent [interleukin-12] *induction* . Positive_regulation IL33 TNF 19801525 2148159 Dexamethasone fails to abolish induced [IL-33] *up-regulation* . Positive_regulation IL33 TNF 19996325 2225082 In human pancreatic myofibroblasts , [IL33] was weakly immunoexpressed without any stimuli , and this was markedly *enhanced* by IL1beta , and lipopolysaccharide (LPS) via the mitogen activated protein kinase (MAPK) dependent AP-1 activation pathway . Positive_regulation IL33 TNF 20405148 2327222 This IL-1ß- and *induced* [IL-33] mRNA expression was mediated by p42/44 mitogen activated protein kinase (MAPK) pathway dependent activation of nuclear factor ( NF ) -?B and activator protein (AP)-1 . Positive_regulation IL33 TNF 20689058 2322869 Activated PSCs expressed [IL-33] in the nucleus , and the expression was *increased* by IL-1ß , , PDGF-BB , and IFN-? , but not TGF-ß1 . Positive_regulation IL33 TNF 2113076 135534 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL33 TNF 21190867 2386072 Moreover , [IL-33] levels are *increased* by and IL-1ß in human bone marrow stromal cells , osteoblasts and adipocytes obtained from three healthy donors . Positive_regulation IL33 TNF 21593768 2454127 GW9508 further suppressed expression of IL-11 , IL-24 , and [IL-33] *induced* in HaCaT cells by and IFN-? . Positive_regulation IL33 TNF 21745554 2471891 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL33 TNF 22277940 2580172 In addition , skin fibroblasts , HaCaT keratinocytes , primary macrophages , and HUVEC endothelial cells efficiently produced [IL-33] in *response* to the combined stimulation of and IFN-? , which was further enhanced by a mimetic of double stranded RNA . Positive_regulation IL33 TNF 23397250 2787077 [IL-33] *induces* CCL2 , and nitric oxide release through phosphorylation of ERK in mouse astrocytes . Positive_regulation IL33 TNF 23567618 2794559 , interferon ( IFN ) -? and IL-1ß significantly *increased* both [IL-33] protein and IL-33 mRNA expression in HACF and HACM as well as in human coronary artery smooth muscle cells ( HCASMC ) . Positive_regulation IL33 TNF 2370931 138337 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL33 TNF 24459820 2884549 and IFN-gamma *induce* expression of [IL-33] , and IL-33 produced by keratinocytes contributes to allergic contact dermatitis . Positive_regulation IL33 TNF 24522896 2924170 [IL-33] is *regulated* by in normal and psoriatic skin . Positive_regulation IL33 TNF 24522896 2924172 Similarly , significantly *increased* [IL-33] mRNA expression in normal human epidermal sheets . Positive_regulation IL33 TNF 24522896 2924173 In particular , we can assess that [IL-33] is *regulated* by in normal and psoriatic skin . Positive_regulation IL33 TNF 3011946 59746 Tumor necrosis interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL33 TNF 3486658 59945 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL33 TNF 3486658 59999 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL33 TNF 3486936 60088 Tumor necrosis factor ( ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL33 TNF 3500495 80697 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL33 TNF 3526909 62638 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL33 TNF 7506142 237734 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL33 TNF 7737374 305506 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL33 TNF 8132326 251512 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL33 TNF 8592105 341902 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL33 TNF 8592105 341957 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL33 TNF 8910536 395198 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL33 TNFSF10 22961755 2701849 but not FasL and TNFa , *regulates* [IL-33] expression in murine hepatocytes during acute hepatitis . Positive_regulation IL33 TNFSF10 22961755 2701854 The expression of [IL-33] during acute hepatitis is *dependent* on , but not on FasL or TNFa . Positive_regulation IL34 ABCG2 20846001 2375393 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL34 CCL17 22057112 2540312 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL34 DAPK1 24220855 2897407 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL34 EPHB2 12609986 1085288 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL34 EPHB2 18310510 1904069 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL34 F3 7635444 317215 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL34 IL1B 14617515 1200633 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL34 IL1B 16375968 1547122 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL34 IL1R2 8387521 218014 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL34 PGC 22117073 2535007 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL34 STAT4 7638186 317672 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL34 TLR7 12045249 950099 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL34 TLR7 18312842 1879284 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Positive_regulation IL34 TLR7 20632067 2367989 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in mediated *activation* of caspase 1 and [interleukin-1ß] . Positive_regulation IL34 TLR7 22521509 2613479 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL34 TLR7 23246311 2731979 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL34 TNF 1463043 206744 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL34 TNF 17854477 1795884 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving *dependent* [interleukin-12] induction . Positive_regulation IL34 TNF 2113076 135539 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL34 TNF 21181166 2499592 Among four inflammatory cytokines [ ( IL-1ß , IL-6 , IL-17 , and tumor necrosis factor-a (TNF-a) ] , [IL-34] mRNA expression level was dramatically *induced* by IL-1ß ( 17-fold ) and ( 74-fold ) . Positive_regulation IL34 TNF 21181166 2499625 IL-1ß- and mediated *induction* of [IL-34] mRNA expression was decreased by JNK inhibitor . Positive_regulation IL34 TNF 21745554 2471901 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL34 TNF 2370931 138342 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL34 TNF 3011946 59751 interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL34 TNF 3486658 59950 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL34 TNF 3486658 60004 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL34 TNF 3486936 60093 ( cachectin ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL34 TNF 3500495 80702 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL34 TNF 3526909 62643 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL34 TNF 7506142 237739 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL34 TNF 7737374 305511 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL34 TNF 8132326 251517 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL34 TNF 8592105 341907 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL34 TNF 8592105 341962 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL34 TNF 8910536 395204 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL36B TNF 20870894 2447334 Messenger ( m ) RNAs for IL-1F6 and IL-1F9 , but not IL-1F5 , [IL-1F8] or IL-1F10 , were significantly *up-regulated* by , IL-1ß , IL-17 and the Toll-like receptor (TLR)3 ligand double stranded ( ds ) RNA . Positive_regulation IL36G TNF 10744718 680704 However , [IL-1H1] could be *induced* in vitro in keratinocytes by interferon-gamma and and in vivo via a contact hypersensitivity reaction or herpes simplex virus infection . Positive_regulation IL37 ABCG2 20846001 2375387 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL37 CCL17 22057112 2540306 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL37 DAPK1 24220855 2897386 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL37 EPHB2 12609986 1085282 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL37 EPHB2 18310510 1904033 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL37 F3 7635444 317139 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL37 IL1B 14617515 1200627 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL37 IL1B 16375968 1547116 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL37 IL1R2 8387521 218002 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL37 PGC 22117073 2535001 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL37 STAT4 7638186 317666 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL37 TLR7 12045249 950053 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL37 TLR7 18312842 1879200 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Positive_regulation IL37 TLR7 19239899 2040528 In this issue of Immunity , Town et al. ( 2009 ) show the interplay between Toll-like receptors ( TLRs ) and cytokines during West Nile virus infection and define a role for *mediated* production of [interleukin-23] in immune cell homing and pathogenesis . Positive_regulation IL37 TLR7 20632067 2367977 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in *mediated* activation of caspase 1 and [interleukin-1ß] . Positive_regulation IL37 TLR7 22521509 2613419 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL37 TLR7 23246311 2731895 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL37 TNF 1463043 206732 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL37 TNF 17854477 1795878 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving dependent [interleukin-12] *induction* . Positive_regulation IL37 TNF 2113076 135533 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL37 TNF 21745554 2471889 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL37 TNF 23600829 2774470 This [IL-37b] *induction* by was mediated by nuclear factor ( NF ) -?B and activator protein (AP)-1 activation . Positive_regulation IL37 TNF 2370931 138336 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL37 TNF 3011946 59745 interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL37 TNF 3486658 59944 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL37 TNF 3486658 59998 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL37 TNF 3486936 60087 ( cachectin ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL37 TNF 3500495 80696 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL37 TNF 3526909 62637 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL37 TNF 7506142 237733 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL37 TNF 7737374 305505 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL37 TNF 8132326 251511 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL37 TNF 8592105 341901 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL37 TNF 8592105 341956 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL37 TNF 8910536 395197 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL3RA TLR7 23679126 2805787 stimulation significantly *increased* IDO protein level in CD14 ( + ) , CD56 ( + ) , CD1c ( + ) , CD11c ( + ) , and [CD123] ( + ) myeloid cells . Positive_regulation IL4 ABCG2 20846001 2375405 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL4 ARSG 24324328 2880248 *regulates* the expression of CaBP9k and [IL-4] receptor genes , and ORZ regulates the expression of the CaBP9k gene , while GABA at 100 mg/kg regulates the expression of the HSP70 gene . Positive_regulation IL4 CAPN8 11119528 768429 On the other hand , spleen cells of immunized mice showed only faint [interleukin-4] production in *response* to in vitro , suggesting that immunization with r-calpain alters the Th1-Th2 balance in murine hosts even during a Th2 promoting S. japonicum infection . Positive_regulation IL4 CCL17 15219001 1263902 In peripheral mononuclear cells from atopic donors , CCL22 and were *induced* by [IL-4] and IL-13 , further supporting the relationship between CCL22/CCL17 and Th2 cytokines . Positive_regulation IL4 CCL17 16810739 1591317 [IL-4] *induces* expression of via two STAT6 binding sites . Positive_regulation IL4 CCL17 22057112 2540324 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL4 CCL17 23686488 2796687 We found that [IL-4] and CD40L are expressed by intratumoral TFH and *induce* production of and CCL22 by FL tumor cells . Positive_regulation IL4 CCL17 23686488 2796690 [IL-4] alone *induces* only but enhances stimulation by CD40L of both CCL17 and CCL22 . Positive_regulation IL4 CCL17 24704819 2938798 Both IL-13 and [IL-4] dose-dependently *induce* production from J774 mouse monocytic cells and CCL11 production from NIH3T3 mouse fibroblasts in the presence of TNFa . Positive_regulation IL4 CD14 9715264 527774 Thus , [IL-4] or CD40 ligation *induced* CD1a+CD14- and DC precursors to differentiate into phenotypically close but functionally different DC populations , suggesting that DC function is primarily determined by their origin . Positive_regulation IL4 COL17A1 17973812 1820559 The degree of improvement in the clinical symptoms , serum [interleukin (IL)-4] , IL-5 , and plasma RANTES concentrations , as well as the *results* of indirect immunofluorescence and enzyme linked immunosorbent assay index values , were compared before and after the 7-day drug administration . Positive_regulation IL4 CST6 11238649 790924 mRNA expression and flow cytometric analysis of infected spleen cells suggested that and IFN-gamma treatment , in addition to greatly reducing parasite numbers , *resulted* in reduced levels of [IL-4] but increased levels of IL-12 and inducible NO synthase . Positive_regulation IL4 DAPK1 24220855 2897443 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL4 EPHB2 11880312 919370 IL-13 and [IL-4] cause eotaxin release in human airway smooth muscle cells : a *role* for . Positive_regulation IL4 EPHB2 12609986 1085300 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL4 EPHB2 16792687 1578839 Inhibition of p38 MAPK , and JAK-2 activities by pretreating the cells with their corresponding inhibitors SB203580 , PD98059 and AG490 , respectively , significantly *suppressed* [IL-4-] and IL-13 induced MCP-1 production in BEAS-2B cells . Positive_regulation IL4 EPHB2 17433443 1736817 In cytokine producing Jurkat T cells , we have found that [IL-4] induces activation of Erk and Akt , and the IL-4 induced STAT6 activity is *suppressed* by inhibitors of and PI3K . Positive_regulation IL4 EPHB2 17433443 1736836 The Ras induced increase of both STAT6 activity and [IL-4] mRNA level was effectively *blocked* by a inhibitor , suggesting that Ras/Erk pathway positively regulates STAT6 activity and IL-4 transcription . Positive_regulation IL4 EPHB2 18310510 1904141 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL4 EPHB2 18682601 1973408 [IL-4] protein expression and basal *activation* of in vivo in follicular lymphoma . Positive_regulation IL4 EPHB2 21989417 2636384 A novel mechanism for *dependent* regulation of [IL4] transcription during human Th2-cell differentiation . Positive_regulation IL4 EPHB2 9533450 496955 However , the production of IL-3 and [IL-4] was only partially *dependent* upon activation , whereas IL-5 , IL-10 , IFN-gamma and GM-CSF production was severely affected by diminished ERK activation . Positive_regulation IL4 F3 7635444 317279 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL4 FAS 17447415 1665564 Moreover , *triggered* expression of [IL-4] and IL-8 when caspase activity was inhibited , but not in the absence of ZVAD . Positive_regulation IL4 HRH1 15021962 1221743 Depletion of the *resulted* in decreases in the release of IL-2 and IL-10 from both CD4+ and CD8+ cells and increases in the release of [IL-4] from CD4+ T cells and IFN-gamma from CD8+ cells . Positive_regulation IL4 IL1B 10088668 599964 The delayed time dependent effect of IL-4 might be partially explained by the *induction* of [IL-4] receptor alpha-chain mRNA expression by . Positive_regulation IL4 IL1B 10861753 705324 After 4 weeks of treatment with E ( 2 ) + DHT , a significant increase in transcript levels of [IL-4] , IL-5 , IL-6 , MIP-2 , eotaxin , and iNOS was *detected* , while and TNF-alpha transcript levels only increased slightly . Positive_regulation IL4 IL1B 12711326 1083269 To investigate whether TGZ acts by affecting the ICAM-1/LFA-1 pathway and/or the Th1/Th2 cytokine balance in NOD mice , we analysed the *induced* ICAM-1 expression on islet-cells and the LFA-1 , CD25 , IL-2 , IFN-gamma , [IL-4] , and IL-10 expression on splenocytes . Positive_regulation IL4 IL1B 14617515 1200645 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL4 IL1B 16375968 1547161 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL4 IL1B 17485153 1744271 Inhibition of and IL-18 secretion by DCs via inhibition of caspase-1 also *led* to a marked decrease of [IL-4] and IL-5 by CD4 ( + ) T cells . Positive_regulation IL4 IL1B 18576346 1935081 Using articular chondrocytes , we showed that our COX-2 promoter construct expressed [IL-4] only in the *presence* of and TNFalpha . Positive_regulation IL4 IL1B 18576346 1935084 [IL-4] expressed in the *presence* of and TNFalpha down-regulated a series of inflammation mediators , prostaglandins , and matrix metalloproteinases . Positive_regulation IL4 IL1B 20114085 2219603 Amelioration of arthritis in B7-1 deficient mice was accompanied by a lower local production of and IL-18 , and *increase* in [IL-4] and IL-10 secretion . Positive_regulation IL4 IL1R2 8387521 218038 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL4 ITGAL 21541792 2463959 Anti-CD11a and anti-CD70 both significantly suppressed the secretion of IFN-? , while significantly *promoted* the secretion of [IL-4] . Positive_regulation IL4 ITGB2 1901520 155820 LFA-1 is upregulated by IFN-gamma in Thyoglicolate- and bone marrow derived M phi and P388D1 cells , while [IL-4] does not *induce* on these cells . Positive_regulation IL4 JAG1 21490151 2422913 In this article , we demonstrate that LT acts as a highly effective adjuvant when administered parenterally , promoting Ag-specific IL-17 , as well as IFN-? , [IL-4] , and IL-10 production in *response* to coadministered . Positive_regulation IL4 JAG1 23630352 2784437 Adoptive transfer of only OX40L ( + ) ( + ) BMDCs *led* to Treg expansion , increased production of [IL-4] and IL-10 , and suppression of EAT in the recipient mice . Positive_regulation IL4 MAP2K6 11305324 803781 While [IL-4] alone does not *induce* activation of , a MEK1 inhibitor suppressed the IL-4 induced proliferative response of LPS activated B cell blasts . Positive_regulation IL4 MAP2K6 17433443 1736844 The Ras induced increase of both STAT6 activity and [IL-4] mRNA level was effectively *blocked* by a inhibitor , suggesting that Ras/Erk pathway positively regulates STAT6 activity and IL-4 transcription . Positive_regulation IL4 MUC16 10229869 611206 [IL-4] *induces* gene expression and goblet cell metaplasia in vitro and in vivo . Positive_regulation IL4 MUC16 20220086 2237293 T cell Ig domain and domain 1 engagement on invariant NKT cells in the presence of TCR stimulation *enhances* [IL-4] production but inhibits IFN-gamma production . Positive_regulation IL4 PCSK9 17996668 1821715 *had* no effect on concanavalin A-induced proliferation , interleukin (IL)-2 secretion and [IL-4] secretion in mouse splenocytes . Positive_regulation IL4 PGC 22117073 2535019 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL4 RORC 24211040 2879427 The limited expansion of human Th17 cells is related to the *dependent* up-regulation of the [interleukin (IL)-4] induced gene 1 ( IL4I1 ) , which encodes for a l-phenylalanine oxidase , that has been shown to down-regulate CD3? expression in T cells . Positive_regulation IL4 SELL 16461740 1540830 Following Con A treatment , deficiency reduced liver mRNA expression of tumor necrosis factor-alpha , and ICAM-1 deficiency *reduced* expression of [interleukin-4] . Positive_regulation IL4 SELL 19004789 1991350 Finally , after anti-CD3/CD28 stimulation , CD4 ( + ) transgenic T cells showed reduced IL-2 and IFNgamma production but increased [IL-4] secretion as a *result* of enhanced IL-4 production of the CD44 ( hi ) ( + ) subset . Positive_regulation IL4 STAT4 16237058 1470737 Moreover , [IL-4] *induced* expression in PDCs through a Stat6 dependent mechanism , and only the Stat4 expressing PDCs produced IFN-gamma . Positive_regulation IL4 STAT4 7638186 317684 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL4 STK39 8258686 238734 Taken together , our data demonstrate that activation of both a and a tyrosine kinase is *involved* in the IL-2 , [IL-4] , and IL-6-stimulation of IgM secretion by SKW6.4 cells and activation of the same or a similar serine/threonine protein kinase is an early step in the signal transduction pathway used by these cytokines . Positive_regulation IL4 TLR7 12045249 950124 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL4 TLR7 16272291 1479293 *dependent* [IL-4] production by invariant Valpha14+Jalpha18+ NKT cells to initiate contact sensitivity in vivo . Positive_regulation IL4 TLR7 18312842 1879452 Toxoplasma profilin is essential for host cell invasion and dependent *induction* of an [interleukin-12] response . Positive_regulation IL4 TLR7 20632067 2368013 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in mediated *activation* of caspase 1 and [interleukin-1ß] . Positive_regulation IL4 TLR7 22521509 2613599 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL4 TLR7 23246311 2732147 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL4 TNF 10030846 591968 However , eosinophil viability and CD69 expression increased synergistically when eosinophils were incubated with IL-13 or [IL-4] in the *presence* of . Positive_regulation IL4 TNF 10861753 705323 After 4 weeks of treatment with E ( 2 ) + DHT , a significant increase in transcript levels of [IL-4] , IL-5 , IL-6 , MIP-2 , eotaxin , and iNOS was *detected* , while IL-1beta and transcript levels only increased slightly . Positive_regulation IL4 TNF 11943316 928694 The objectives of this study were to determine interleukin (IL)-1 beta , IL-2 , [IL-4] , IL-5 , IL-6 , IL-8 , IL-10 , interferon (IFN)-gamma and *induction* in bronchoalveolar lavage (BAL) of control horses and horses with heaves both during remission and exacerbation of the disease , and to determine the effect of therapy with inhaled fluticasone propionate on the cytokine profile of horses with heaves . Positive_regulation IL4 TNF 12037401 949223 No changes in VCAM-1 expression were *induced* by TNF-alpha , [IL-4] or bFGF , whereas both and IL-4 increased eotaxin release ( p < 0.05 ) . Positive_regulation IL4 TNF 12479648 1024077 The reduction in DSS induced inflammation noted with PPARgamma ligand treatment was associated with decreased interferon-gamma and and *increased* [interleukin (IL)-4] and IL- 10 levels as assessed by quantitative reverse transcriptase-polymerase chain reaction . Positive_regulation IL4 TNF 12974750 1139766 Analysis of mRNA expression of cytokines in the spleen revealed no alterations in , transforming growth factor (TGF)-beta , interleukin (IL)-12 and interferon (IFN)-gamma and *induction* of IL-10 and [IL-4] . Positive_regulation IL4 TNF 1315359 185446 [IL-4] together with IL-1 induced IgE secretion , and the IgE secretion was further *increased* by . Positive_regulation IL4 TNF 1373645 186064 IL-5 , IL-6 , and TNF-alpha enhance IL-4 dependent IgE synthesis , but only *enhanced* [IL-4] induced germline epsilon RNA synthesis . Positive_regulation IL4 TNF 1463043 206768 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL4 TNF 15149503 1248388 is the main *inducer* of IP-10 by skin fibroblasts , but not IFN-gamma or [IL-4] . Positive_regulation IL4 TNF 15634596 1349534 In recovery SAA patients , the serum levels of significantly decreased to ( 1.46 +/- 1.41 ) microg/L ( P < 0.01 ) , and the levels of [IL-4] *increased* markedly to ( 3.05 +/- 1.94 ) microg/L . Positive_regulation IL4 TNF 15866472 1402047 On the other hand , neutrophil depletion of susceptible BALB/c mice did not affect the expression of and monocyte derived chemokine (MDC) in peritoneal macrophages but *induced* the early stage expression of [IL-4] in draining lymph node cells and exacerbated the footpad lesions and increased the parasite burden . Positive_regulation IL4 TNF 1690777 128487 IFN-gamma and were essential to the killing mechanism whereas Il-1 , Il-2 , and [Il-4] were not *required* . Positive_regulation IL4 TNF 17709600 1848759 These results suggest that , in the *presence* of , [IL-4] and IFN-gamma reciprocally regulate tube formation by HMVEC-Ls through autocrine synthesis of CXCR2 and CXCR3 chemokines , respectively . Positive_regulation IL4 TNF 17854477 1795896 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving *dependent* [interleukin-12] induction . Positive_regulation IL4 TNF 18576346 1935080 Using articular chondrocytes , we showed that our COX-2 promoter construct expressed [IL-4] only in the *presence* of IL-1beta and . Positive_regulation IL4 TNF 18576346 1935083 [IL-4] expressed in the *presence* of IL-1beta and down-regulated a series of inflammation mediators , prostaglandins , and matrix metalloproteinases . Positive_regulation IL4 TNF 1972165 135335 IL-2 and [IL-4] were both growth promoting for human T cells but only IL-2 could efficiently *induce* production . Positive_regulation IL4 TNF 20347489 2307335 IL-8 , IL-6 and *increased* , and [IL-4] decreased during the challenge in both groups . Positive_regulation IL4 TNF 20798517 2313710 The results showed that TNF induced up to 2.7-fold increase in IL-4 , but not IL-12 release from P815 cells , and PAR-2 antagonist peptide FSLLRY-NH ( 2 ) and PAR-4 antagonist peptide trans-cinnamoyl ( tc ) -YPGKF-NH ( 2 ) did not affect *induced* [IL-4] release . Positive_regulation IL4 TNF 20798517 2313712 In conclusion , can *stimulate* [IL-4] release from mast cells through an Akt cell signalling pathway dependent , but PAR independent mechanism . Positive_regulation IL4 TNF 2113076 135551 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL4 TNF 21745554 2471925 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL4 TNF 22765163 2639496 In terms of T-cell response , the production of [IL-4] from lung T cells after OVA challenge was enhanced by airway sensitization with OVA plus low-dose poly [ I:C ] in WT mice , and this phenotype was *inhibited* by the absence of . Positive_regulation IL4 TNF 22946308 2667107 IHT sharply lowered pro-inflammatory cytokine in both groups , significantly *increased* [IL-4] in RT subjects ; Positive_regulation IL4 TNF 23171464 2700405 ( iv ) decreased secretion of , IL-12 , interferon-? and IL-2 and ( v ) but *up-regulated* [IL-4] and transforming growth factor beta ( TGF-ß ) in the lymph nodes . Positive_regulation IL4 TNF 2370931 138354 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL4 TNF 24879793 2945830 IL-13Ra2 expression can be *induced* in lung fibroblasts by [IL-4] or IL-13 via a STAT6 dependent mechanism , or by via a STAT6 independent mechanism . Positive_regulation IL4 TNF 2677211 119479 Although B cells generally also produced and TNF-beta upon stimulation , [IL-4] did not *induce* TNF secretion and seemingly had a specific effect on IL-6 production . Positive_regulation IL4 TNF 2785566 111569 RNA hybridization studies demonstrated that [IL-4] does not *induce* transcription of IL-1 or . Positive_regulation IL4 TNF 3011946 59763 interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL4 TNF 3486658 59962 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL4 TNF 3486658 60016 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL4 TNF 3486936 60105 ( cachectin ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL4 TNF 3500495 80714 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL4 TNF 3526909 62655 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL4 TNF 7506142 237751 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL4 TNF 7583927 333594 In LPL , there was no SEE induced IL-2 or [IL-4] production , but IL-6 , , and gamma interferon were *induced* . Positive_regulation IL4 TNF 7583927 333613 In IEL , SEE *induced* no IL-2 , [IL-4] , or gamma interferon but produced IL-6 and TNF , while SEB stimulation resulted in no IL-2 or gamma interferon but did result in detectable IL-4 , IL-6 , and . Positive_regulation IL4 TNF 7737374 305523 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL4 TNF 8132326 251529 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL4 TNF 8280160 240559 *upregulates* [interleukin-4] receptors on murine sarcoma cells . Positive_regulation IL4 TNF 8592105 341919 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL4 TNF 8592105 341974 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL4 TNF 8834369 386019 [Interleukin-4] prevents mortality from acute but not chronic murine peritonitis and *induces* an accelerated response . Positive_regulation IL4 TNF 8871669 389627 Addition of an Ab to IL-10 suggested that the stimulatory effects of LPS on p75 receptor expression were due , at least in part , to LPS stimulation of IL-10 production and that [IL-4] *acted* , in part , by decreasing IL-10 production . Positive_regulation IL4 TNF 8910536 395216 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL4 TNF 9927530 588645 We investigated the *role* of in the regulation of MHC class II antigens and cytokine mRNA expression of TNF , interferon-gamma (IFN) , IL-2 , [IL-4] , and IL-10 in cardiac allografts to elucidate its immunological mechanism . Positive_regulation IL4R TNF 9038152 415341 By flow cytofluorometry and receptor binding analysis of iodinated IL-4 and IL-13 , stimulation with *induced* a 2-3-fold increase of the [IL-4Ralpha] expression . Positive_regulation IL5 ABCG2 20846001 2375406 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL5 CCL17 22057112 2540325 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL5 COL17A1 17973812 1820560 The degree of improvement in the clinical symptoms , serum interleukin (IL)-4 , [IL-5] , and plasma RANTES concentrations , as well as the *results* of indirect immunofluorescence and enzyme linked immunosorbent assay index values , were compared before and after the 7-day drug administration . Positive_regulation IL5 DAPK1 24220855 2897446 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL5 EPHB2 12609986 1085301 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL5 EPHB2 18310510 1904147 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL5 F3 7635444 317282 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL5 IL1B 10489836 645369 These findings suggest that the role of alveolar macrophages from atopic asthmatics in enhancing [interleukin-5] production by allergen-specific CD4+ T-cells is *due* , at least partly , to their aberrant production of , interleukin-6 , and particularly of interleukin-12 . Positive_regulation IL5 IL1B 10725746 677673 *Activation* of HUVEC by or TNF-alpha or priming of eosinophils by [IL-5] both promote CCR3 dependent migration of eosinophils from the vasculature in conjunction with CCR3-active chemokines . Positive_regulation IL5 IL1B 11988651 936347 Variances were noted depending on the type of fluid : HTD and LR solution did not induce expression of [IL-5] , and HTD also did not *induce* expression . Positive_regulation IL5 IL1B 14617515 1200646 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL5 IL1B 15544852 1355255 We addressed whether 5-HT is affected during *induced* anorexia in obese Zucker rats and the influence of the central NO system on this [IL-1beta/5-HT] interaction . Positive_regulation IL5 IL1B 16375968 1547162 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL5 IL1B 17485153 1744273 Inhibition of and IL-18 secretion by DCs via inhibition of caspase-1 also *led* to a marked decrease of IL-4 and [IL-5] by CD4 ( + ) T cells . Positive_regulation IL5 IL1B 9053967 345090 Although and IFN-gamma mRNA were detected in most specimens , IL-2 , IL-3 , IL-4 , [IL-5] , IL-9 , TNF-alpha , and IFN-beta mRNA were not *detected* at all . Positive_regulation IL5 IL1R2 8387521 218040 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL5 JAG1 16818743 1581293 In contrast , Delta1 knockdown in CD4 ( + ) T cells selectively *enhanced* production of IFN-gamma , IL-2 , and [IL-5] in response to polyclonal stimulation , while or Jagged2 knockdown had no effect . Positive_regulation IL5 PGC 22117073 2535020 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL5 STAT4 7638186 317685 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL5 TLR7 12045249 950125 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL5 TLR7 18312842 1879466 Toxoplasma profilin is essential for host cell invasion and dependent *induction* of an [interleukin-12] response . Positive_regulation IL5 TLR7 18377768 1888580 signals in mast cells *increase* their release of [IL-5] , and TLR signals in airway epithelial cells enhance airway generation of proallergic cytokines . Positive_regulation IL5 TLR7 20632067 2368015 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in mediated *activation* of caspase 1 and [interleukin-1ß] . Positive_regulation IL5 TLR7 21624504 2481062 signaling in mast cells *increases* the release of [IL-5] , and TLR activation of airway epithelial cells forces the generation of proallergic Th2 type of cytokines . Positive_regulation IL5 TLR7 22521509 2613609 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL5 TLR7 23246311 2732161 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL5 TNF 10725746 677672 *Activation* of HUVEC by IL-1beta or or priming of eosinophils by [IL-5] both promote CCR3 dependent migration of eosinophils from the vasculature in conjunction with CCR3-active chemokines . Positive_regulation IL5 TNF 1463043 206770 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL5 TNF 17854477 1795897 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving dependent [interleukin-12] *induction* . Positive_regulation IL5 TNF 2113076 135552 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL5 TNF 21402950 2411942 from inflammatory dendritic cells (DCs) *regulates* lung [IL-17A/IL-5] levels and neutrophilia versus eosinophilia during persistent fungal infection . Positive_regulation IL5 TNF 21745554 2471927 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL5 TNF 2370931 138355 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL5 TNF 3011946 59764 interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL5 TNF 3486658 59963 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL5 TNF 3486658 60017 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL5 TNF 3486936 60106 Tumor necrosis factor ( ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL5 TNF 3500495 80715 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL5 TNF 3526909 62656 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL5 TNF 7506142 237752 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL5 TNF 7737374 305524 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL5 TNF 8132326 251530 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL5 TNF 8592105 341920 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL5 TNF 8592105 341975 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL5 TNF 8910536 395217 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL6 ABCA4 18591233 1946946 However , contrarily to nMP65 , did not *induce* tumor necrosis factor alpha and [interleukin-6] release from these cells . Positive_regulation IL6 ABCG2 20846001 2375407 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL6 ADRB2 11096136 755711 activation *regulates* tumour necrosis factor (TNF)-alpha and [interleukin-6 (IL-6)] production in cultured renal cells . Positive_regulation IL6 ALOX5 1954875 172451 In contrast , the general lipoxygenase inhibitor nordihydroguaiaretic acid ( 10 microM ) and the more specific <5-lipoxygenase> inhibitors AA861 and RHC5901 ( both 10 microM ) reduced basal and *blocked* IL-1 beta induced [IL-6-release] . Positive_regulation IL6 ANGPT1 24404127 2900500 While TNF enhanced expression of a common restricted set of genes involved in angiogenesis and inflammation in GM-CSF , IFN-? and IL-10 -differentiated macrophages , expression of multiple chemokines and cytokines , including CXCL3 , CXCL5 , CXCL8 , [IL6] , and IL12B was further augmented in the *presence* of and Ang-2 , via Tie2 activation of JAK/STAT signaling . Positive_regulation IL6 BPI 9366436 463315 Confirming earlier published studies , inhibited , and LBP enhanced , the ability of LPS to *stimulate* PBMC production of the cytokines TNF-alpha and [IL-6] . Positive_regulation IL6 CAPN8 15985533 1428595 We observed a smoke extract induced , *dependent* degradation of the intracellular form of platelet-endothelial cell adhesion molecule 1/CD31 , as well as a release of P-selectin/CD62P , [IL-6] , and IL-8 from endothelial cells into the supernatant . Positive_regulation IL6 CAPN8 22046434 2503869 We found that the calpastatin-calpain balance varied during Th1 , Th2 , and Th17 development , and that overexpression of a minimal domain of calpastatin ( by retroviral gene transduction ) or the inhibition of by E-64-d *suppressed* the production of [IL-6] and IL-17 by Th cells and the production of IL-6 by fibroblasts . Positive_regulation IL6 CCL17 22057112 2540326 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL6 CCND1 12730884 1086818 Leptin replacement corrected these defects in ob/ob mice by restoring TNF and [IL-6] release and *inducing* . Positive_regulation IL6 CD14 11485266 844852 These results suggest the [IL-6] expression by pulp cell cultures is *dependent* and regulated at the transcriptional level , and a combined treatment with immunoregulatory cytokines may be effective for control of pulpal inflammation due to P. intermedia LPS . Positive_regulation IL6 CD14 15661814 1381990 Furthermore , the *upregulation* of CD80 , CD86 , MHC class II and [interleukin-6] by ( + ) monocytes following activation with specific TLR ligands was decreased ( P < 0.05 ) in samples obtained following exercise compared with at rest . Positive_regulation IL6 CD14 15863460 1439683 Low concentrations ( ng/ml ) of Escherichia coli LPS , the prototypical TLR4 agonist , markedly stimulated extracellular regulated kinase 1/2 ( ERK1/2 ) activity , induced release of monocyte-chemoattractant protein-1 ( MCP-1 ) and [interleukin (IL)-6] , and stimulated IL-1alpha expression in human aortic SMC , and exogenous *enhanced* these effects . Positive_regulation IL6 CD14 16249503 1471751 In a dose-dependant manner , tear and LBP *mediated* the secretion of [interleukin (IL)-6] and IL-8 by corneal epithelia cells when challenged with LPS . Positive_regulation IL6 CD14 1724578 175451 These findings suggest that the expression of on the surface of U937 cells cultured with formalin killed Gram negative bacteria is *induced* by [interleukin-6] and can be explained on the basis of the autocrine mechanism of interleukin-6 . Positive_regulation IL6 CD14 20946675 2337949 The activation of , TLR4 , and TLR2 by mmLDL *induces* IL-1ß , [IL-6] , and IL-10 secretion in human monocytes and macrophages . Positive_regulation IL6 CD14 7520002 266258 This was functional in that lipopolysaccharide stimulation *induced* [interleukin (IL)-6] and IL-10 in clones 1 and 2 but not in clone 3 . Positive_regulation IL6 CD14 7681082 214210 We conclude that is *involved* in LPS induced release of TNF-alpha , [IL-6] , and IL-8 by monocytes and alveolar macrophages and that this receptor appears to be able to recognize LPS directly in the absence of serum . Positive_regulation IL6 CLU 12499214 1033649 Although decreased the intracellular expression levels of tumor necrosis factor alpha and interleukin 1beta (IL-1beta) and *increased* [IL-6] expression in macrophages , cytokine mRNA expression levels were similar in CLI treated and untreated groups . Positive_regulation IL6 CLU 15519757 1328973 In contrast to adult glia , neonatal secretion did not respond to IL-1 beta , IL-6 , or TNFalpha , and ApoE secretion from neonatal glia was slightly *increased* by [IL-6] . Positive_regulation IL6 CTGF 18639630 1954656 CTGF stimulated binding of NF-kappaB to the IL-6 promoter , and siRNA targeting the NF-kappaB subunit RelA interfered with *induced* [IL-6] expression , implicating the NF-kappaB pathway in the mediation of the CTGF effect . Positive_regulation IL6 CTGF 23227240 2708233 OASFs stimulation with *induced* concentration dependent increases in [IL-6] expression . Positive_regulation IL6 CTGF 23227240 2708237 Our results suggest that *increased* [IL-6] production in OASFs via the avß5 integrin , ASK1 , p38/JNK , and AP-1/NF-?B signaling pathways . Positive_regulation IL6 CTGF 23827951 2820814 stimulation *resulted* in the significant production of [IL-6] , IL-8 , C-C motif ligand 2 (CCL2) , CCL20 , MMP-1 and MMP-3 in FLSs in the presence , but not in the absence , of IL-1ß . Positive_regulation IL6 DAPK1 24220855 2897449 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL6 EDN2 7919371 272787 *Stimulation* of [interleukin-6] production by in rat bone marrow derived stromal cells . Positive_regulation IL6 EDN2 9124553 424019 *stimulates* osteoblastic production of [IL-6] but not macrophage colony stimulating factor . Positive_regulation IL6 EPHB2 11231289 789508 Pharmacologic inhibition of either the or the p38 MAPK pathway , using U0126 and SB203580 , respectively , *reduced* [interleukin-6] protein induction by at least 70 % , and combined inhibition of both pathways fully blocked interleukin-6 protein expression and reduced interleukin-6 mRNA induction by more than 80 % . Positive_regulation IL6 EPHB2 12582006 1084901 Inhibitors of , JNK , and p38 *reduced* LC-induced [IL-6] and MCP-1 production . Positive_regulation IL6 EPHB2 12609986 1085302 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL6 EPHB2 14579272 1156759 However , pharmacological blockade of p38 or ERK demonstrated that p38 inhibition abrogated both basal and beta4 integrin induced production of IL-6 preventing NF-kappaB and NF-IL6 activation , whereas inhibition *reduced* [IL-6] production , hampering only NF-kappaB activation . Positive_regulation IL6 EPHB2 15913932 1451837 Increased [IL-6] by DFX was significantly *inhibited* by p38 inhibitor , SB203580 ( about 72 % inhibition , P=0.027 ) but not inhibitor , PD98059 or JNK inhibitor , SP600125 . Positive_regulation IL6 EPHB2 16005185 1452945 VEGF and TIMP-2 expression in PC3 cells are dependent on AKT activation and activation in LNCaP and LNCaP C4-2B cells *leads* to [IL-6] or IL-8 secretion . Positive_regulation IL6 EPHB2 16297883 1502774 Dioscorin also stimulated multiple signaling molecules ( NF-kappaB , , JNK , and p38 ) and *induced* the expression of cytokines ( TNF-alpha , IL-1beta , and [IL-6] ) in murine RAW 264.7 macrophages . Positive_regulation IL6 EPHB2 16543474 1574623 Inhibition of or PI3K *suppressed* the enhanced production of [IL-6] in SHIP-deficient macrophages . Positive_regulation IL6 EPHB2 17761160 1801739 These results suggest that and calcineurin are cooperatively *involved* in UTP induced [IL-6] production . Positive_regulation IL6 EPHB2 18310510 1904153 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL6 EPHB2 19211730 2054271 Finally , the CRH-R antagonists alpha-helical ( 9-41 ) CRH and astressin-2B completely inhibit Ucn induced [IL-6] release , as well as *activation* of , p38 , and NF-kappaB . Positive_regulation IL6 EPHB2 19211919 2061568 Exogenous angiotensin II induced [IL-6] expression , *activation* of 1/2 , and superoxide generation in pancreatic acinar cell line AR42J , which were reversed by the angiotensin II type 1 ( AT(1) ) receptor antagonist , losartan ( 2-butyl-4-chloro-1- [ p- ( o-1H-tetrazol-5-ylphenyl ) benzyl ] imidazole-5-methanol monopotassium salt , C ( 22 ) H ( 23 ) ClN(6)O ) . Positive_regulation IL6 EPHB2 19299480 2106076 In the present study , we demonstrate that CGRP is involved in morphine tolerance by differentially regulating the *dependent* up-regulation of IL-1beta , TNF-alpha , and microsomal prostaglandin E synthase-1 ( mPGES-1 ) in astrocytes and p38 dependent up-regulation of [IL-6] in microglia in the rat spinal cord . Positive_regulation IL6 EPHB2 19479862 2097673 The MAPKs p38 , JNK , and were *necessary* for [IL-6] production , but phosphatidylinositol 3-kinase ( PI 3-kinase ) was required for selective CCL5 induction . Positive_regulation IL6 EPHB2 19632320 2124499 Interestingly , the ability of cAMP elevation to inhibit [IL-6] signalling was *blocked* by inhibition . Positive_regulation IL6 EPHB2 19756962 2195451 IL-33 scarcely affected the growth and tube formation of the endothelial cells , but *induced* [IL-6] and IL-8 secretion from endothelial cells with the rapid activation of extracellular signal regulated kinase ( ) 1/2 , so IL-33 is supposed to involve in inflammatory reaction of vascular endothelial cells through its receptor , ST2L . Positive_regulation IL6 EPHB2 20107167 2258749 The zymosan induced release of [IL-6] and IL-8 was *attenuated* by inhibitors of , p38 , JNK , and NF-kappaB signaling . Positive_regulation IL6 EPHB2 20204057 2180982 *Upregulation* of Salmonella induced [IL-6] production in Caco-2 cells by PJ-34 , PARP-1 inhibitor : involvement of PI3K , p38 MAPK , , JNK , and NF-kappaB . Positive_regulation IL6 EPHB2 21054880 2349384 signalling is *necessary* for synergistic induction of [IL-6] by palmitate and insulin . Positive_regulation IL6 EPHB2 21263382 2414444 [IL-6] *induced* phosphorylation of , JNK , and PI3K , and inhibition of each suppressed IL-6 induced VEGF production . Positive_regulation IL6 EPHB2 23541910 2788868 Further examination indicated that , although IL6 was able to activate Erk in sparsely growing cells , [IL6] could not *induce* an increase in activity levels in densely growing cultures . Positive_regulation IL6 EPHB2 23619565 2804769 Further studies revealed that PL suppressed the production of tumor necrosis factor-a (TNF-a) or [Interleukin (IL)-6] and *activation* of nuclear factor-?B ( NF-?B ) or 1/2 by LPS . Positive_regulation IL6 EPHB2 23677697 2805656 [IL-6] also *induces* a temporary and significant activation of , but not sustained activation , and change sustained activation in MPP ( + ) -treated group into temporary activation . Positive_regulation IL6 EPHB2 23734186 2796936 Bla g 2 can stimulate up-regulation of inflammatory cytokines including TNF-alpha and [IL-6] and *activation* of nuclear factor kappa B ( NF-kB/p65 ) , p38 mitogen activated protein kinase ( p38 ) , , and JNK in cultured fibrocytes . Positive_regulation IL6 EPHB2 23734186 2796954 This increased secretion of TNF-alpha and [IL-6] and *activation* of NF-kB , , and JNK was significantly inhibited by the addition of either mannan or mannose . Positive_regulation IL6 EPHB2 24262867 2898245 Further studies revealed that PT suppressed the production of tumor necrosis factor-a (TNF-a) or [Interleukin (IL)-6] and *activation* of nuclear factor-?B ( NF-?B ) or 1/2 by LPS . Positive_regulation IL6 EPHB2 24557363 2919284 NF-?B inhibitor and inhibitor significantly *inhibited* [IL-6] and CCL20 productions from IL-1ß stimulated HPDLCs . Positive_regulation IL6 F2R 10343541 616590 mediated signals *induce* expressions of [interleukin 6] and granulocyte colony stimulating factor via NF-kappa B activation in synovial fibroblasts . Positive_regulation IL6 F2R 11104585 756427 Thrombin induces IL-6 but not TNFalpha secretion by mouse mast cells : threshold-level and very low level FcepsilonRI signaling synergistically *enhance* [IL-6] secretion . Positive_regulation IL6 F2R 11907122 923286 , PAR-2 , or PAR-4 , in combination , *caused* additive [IL-6] release , but only the PAR-1 and PAR-2 combination resulted in an additive IL-8 response . Positive_regulation IL6 F2R 12506061 1038280 HCE-T expression of cytokines ( [IL-6] , IL-8 , and TNFalpha ) in *response* to activation of and -2 was measured by quantitative RT-PCR and ELISA . Positive_regulation IL6 F2R 14719142 1197732 mediated signaling *stimulated* PKC and NF-kappaB dependent [IL-6] and IL-8 gene expression via phosphoinositide 3-kinase and further downstream via p42/44 and p38 MAPKs . Positive_regulation IL6 F2R 14719142 1197736 Thus , *mediated* [IL-6/IL-8] gene expression is uncoupled from Sp1 inhibition and may support proinflammatory pathomechanisms probably involved in hemorrhage/HCMV retinitis progression . Positive_regulation IL6 F2R 16869943 1607362 *Induction* of [IL-6] release from human T cells by and PAR-2 agonists . Positive_regulation IL6 F2R 18062909 1867672 Thrombin induced [IL-6] production in human synovial fibroblasts is *mediated* by , phospholipase C , protein kinase C alpha , c-Src , NF-kappa B and p300 pathway . Positive_regulation IL6 F2R 18062909 1867676 By using pharmacological inhibitors or activators or genetic inhibition by the protease activated receptor (PAR) , siRNA revealed that the receptor but not other PAR receptors is *involved* in thrombin mediated up-regulation of [IL-6] . Positive_regulation IL6 F2R 21760880 2456286 Through the use of PAR-1 and PAR-2 neutralizing antibodies , it was determined that is *essential* for GrK induced [IL-6] , IL-8 and MCP-1 release . Positive_regulation IL6 F2R 23352962 2754150 MAb 8E8 or agonist peptide *stimulated* [IL-6] and IL-8 production and VCAM-1 expression in HPMEC-ST1.6R cells . Positive_regulation IL6 F3 7635444 317285 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL6 FAS 11949822 930263 engagement *increases* expression of [interleukin-6] in human glioma cells . Positive_regulation IL6 FAS 23967134 2832633 E3330 treatment prevented the functional activation of NF-?B via the alteration of APE1 subcellular trafficking and reduced [IL-6] and IL-8 expression *induced* by TNF-a and accumulation through blockage of the redox mediated activation of NF-?B . Positive_regulation IL6 FAS 8597871 342618 In this cell line mobilizes the p50/p65 heterodimeric form of NF-kappa B and *induces* [interleukin-6 (IL-6)] production . Positive_regulation IL6 FLG 18669607 1943236 Taken together these data demonstrate that and LPS *stimulate* the up-regulation of expression of [IL-6] and CXCLi2 through an ERK1/2 dependent activation of both NF-kappaB and AP-1 . Positive_regulation IL6 GLP1R 24048027 2846353 induced suppression of food intake , and body weight is *mediated* by central IL-1 and [IL-6] . Positive_regulation IL6 GLP1R 24048027 2846359 activation in the mouse neuronal Neuro2A cell line also *resulted* in increased [IL-6] expression . Positive_regulation IL6 GPR132 19063986 2127658 In human epidermal keratinocytes , *mediates* the secretion of cytokines including [interleukin-6] and -8 , and blocks cell cycle progression at the G1 phase in response to ligands . Positive_regulation IL6 HBEGF 17822789 1817479 According to our data , *increased* transcription of [IL-6] , cardiotrophin-1 (CT-1) , leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) . Positive_regulation IL6 HBEGF 17822789 1817481 The secretion of [IL-6] was also *increased* by . Positive_regulation IL6 HBEGF 17822789 1817482 Furthermore , these *mediated* up-regulation of [IL-6] mRNA expression and secretion were inhibited by NF-kappaB inhibitor Bay117082 ( 2.5 microM ) treatment suggesting involvement of NF-kappaB pathway . Positive_regulation IL6 HES2 23245375 2711191 improved liver microcirculation , cardiac index and DO ( 2 ) -I , but significantly *increased* IL-1ß , [IL-6] and TNF-a levels and resulted in a mortality rate of 33 % . Positive_regulation IL6 IFI27 14764608 1227371 [Interleukin-6] *induces* expression of , an interferon-inducible candidate gene for lupus susceptibility . Positive_regulation IL6 IL1B 10074208 594746 *Induction* of [interleukin-6 (IL-6)] and ICAM-1 by was not suppressed by infection with EZ , suggesting that the inhibition of IFN signaling is specific . Positive_regulation IL6 IL1B 10088668 599961 In this report , we describe the sequential effects of IL-4 and IL-10 on the production of [interleukin-6 (IL-6)] *induced* by in mouse primary astrocytes and compare these effects to those of the synthetic glucocorticoid agonist , dexamethasone . Positive_regulation IL6 IL1B 10342040 616478 Furthermore , both nimesulide and diclofenac at therapeutic concentrations significantly decreased spontaneous and *stimulated* [IL-6] production by human chondrocytes , but did not modify IL-8 production . Positive_regulation IL6 IL1B 10349852 616985 Whereas , tumor necrosis factor-alpha , and transforming growth factor-beta mRNA levels remained unchanged , stimulation of astrocytoma cells ( T98G , CB193 , U118MG ) by C3a , C5a , and peptidic C3aR and C5aR agonists *induced* an increase in the [IL-6] mRNA level . Positive_regulation IL6 IL1B 10391095 626200 In the conditioned medium , marked [IL-6] secretion was *induced* from WI-38 cells by or TNF-alpha . Positive_regulation IL6 IL1B 10405202 629292 Stimulation with lipopolysaccharide and *resulted* in the full induction of [IL-6] expression only if the cells were coincubated with cAMP agonists ; Positive_regulation IL6 IL1B 10457265 639288 In addition , testosterone also suppressed *stimulated* [IL-6] mRNA levels by 57 % , while the adrenal androgen dehydroepiandrosterone had no effect . Positive_regulation IL6 IL1B 10467171 640688 *induces* [interleukin-6] production through the production of prostaglandin E ( 2 ) in human osteoblasts , MG-63 cells . Positive_regulation IL6 IL1B 10467171 640689 This study was conducted to investigate the mechanism of *induced* [IL-6] production in human osteoblasts ( MG-63 cells ) . Positive_regulation IL6 IL1B 10467171 640691 Stimulation with *resulted* in the production of [IL-6] and prostaglandin E ( 2 ) ( PGE ( 2 ) ) . Positive_regulation IL6 IL1B 10467171 640693 These findings indicate that *induced* [IL-6] production in MG-63 cells involves the following sequence of steps : IL-1beta induced COX-2 activation , PGE ( 2 ) production , and EP-1 receptor signaling prior to IL-6 production . Positive_regulation IL6 IL1B 10471086 641459 We found that tepoxalin markedly inhibits *induced* [IL-6] and ACT synthesis in astrocytes and the synthesis of IL-1beta and IL-6 in lipopolysaccharide (LPS) stimulated microglial cells . Positive_regulation IL6 IL1B 10478575 643374 Adrenaline and *increased* the release of [interleukin-6] from the cells in a concentration dependent manner . Positive_regulation IL6 IL1B 10516225 652310 Interleukin (IL)-1alpha , , and tumor necrosis factor-alpha showed increased mRNA by 30 min after IT LPS instillation , but [IL-6-] and cytokine induced neutrophil chemoattractant mRNAs were not substantially *increased* until 2 h after IT LPS instillation . Positive_regulation IL6 IL1B 10559516 566645 However , IL-1beta induced productions of both MCP-1 and IL-8 were dose-dependently suppressed by enrichment of cells with vitamin E. Vitamin E , at the doses used , did not significantly change the spontaneous production but dose-dependently inhibited the *induced* production of inflammatory cytokine [IL-6] . Positive_regulation IL6 IL1B 10564140 567136 The experiments demonstrate that LPS , TNF-alpha , IL-1beta , and [IL-6] *induce* lowering of P ( if ) when given intravenously or intra-arterially , whereas only TNF-alpha , , and IL-6 induce lowering of P ( if ) when given subdermally . Positive_regulation IL6 IL1B 10579318 569623 Sustained levels of in blood over time *contribute* to the high peripheral [IL-6] response . Positive_regulation IL6 IL1B 10615257 575796 Production rates of [interleukin 6] and prostaglandin E2 were significantly *increased* by , tumour necrosis factor alpha and lipopolysaccharide in explants from tissues taken during and before labour , while the responsiveness of interleukin 10 production to these treatments was inconsistent . Positive_regulation IL6 IL1B 10620700 657678 We examined the role of p38 mitogen activated protein (MAP) kinase in the tumor necrosis factor alpha (TNF-alpha)- or *induced* production of [interleukin-6 (IL-6)] and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Positive_regulation IL6 IL1B 10623445 658050 In contrast , IL-1beta and [IL-6] production by Mbeta from young males was suppressed and IL-10 production *enhanced* following trauma-haemorrhage , whereas Mstraight phi from aged males produced elevated levels of and IL-6 and suppressed levels of IL-10 following trauma-haemorrhage . Positive_regulation IL6 IL1B 10626139 576255 has potent OAF activity , can increase the expression of adhesion molecules , and can *induce* paracrine [IL-6] production ( see Fig. 1 ) . Positive_regulation IL6 IL1B 10632674 659819 and TNF-alpha strongly *stimulated* [IL-6-type] cytokine release ( except for OSM ) by both OB and BMSC . Positive_regulation IL6 IL1B 10669630 665766 Adhesion of monocyte very late antigen-4 to endothelial vascular cell adhesion molecule-1 induces *dependent* expression of [interleukin-6] in endothelial cells . Positive_regulation IL6 IL1B 10679106 668789 Lipoxin A4 inhibits *induced* [IL-6] , IL-8 , and matrix metalloproteinase-3 production in human synovial fibroblasts and enhances synthesis of tissue inhibitors of metalloproteinases . Positive_regulation IL6 IL1B 10679106 668793 *induced* the synthesis of [IL-6] , IL-8 , and matrix metalloproteinases (MMP)-1 and -3 . Positive_regulation IL6 IL1B 10699574 672118 The induced anti-IL-1alpha aAb inhibited binding of IL-1alpha to the murine T-cell line NOB-1 by simple competition and neutralised IL-1alpha , but not *induced* [IL-6] in vivo . Positive_regulation IL6 IL1B 10712813 674189 Tumor necrosis factor-alpha , although ineffective alone , increased *induced* [interleukin-6] release in a concentration dependent manner when co-incubated with interleukin-1betafor 18 hr . Positive_regulation IL6 IL1B 10712813 674191 However , tumor necrosis factor-alphadid not enhance *induced* [interleukin-6] release if co-incubated with interleukin-1betafor a shorter time ( 6 hr ) . Positive_regulation IL6 IL1B 10712813 674192 However , neither the adenyl cyclase activator , forskolin or the adenosine 3 ' , 5'-cyclic monophosphate-mimetic , dibutyryl 3',5'-cyclic monophosphate enhanced *induced* release of [interleukin-6] . Positive_regulation IL6 IL1B 10712813 674193 Although agents that activate the adenyl cyclase/adenosine 3 ' , 5'-cyclic monophosphate system through cell surface G-protein transduced receptors increased *induced* release of [interleukin-6] , the ineffectiveness of forskolin and dibutryl 3 ' , 5'-cyclic monophosphate suggest that simply increasing intracellular 3',5'-cyclic monophosphate is not sufficient to augment interleukin-1beta induced release of interleukin-6 . Positive_regulation IL6 IL1B 10716623 676488 These results give further support to the observation that can *increase* the [IL-6] secretion from PDL cells . Positive_regulation IL6 IL1B 10728932 579487 alone or a combination of TNF-alpha and IL-1beta comparably *increased* [IL-6] and IL-8 mRNA levels slightly . Positive_regulation IL6 IL1B 10731686 678283 Moreover , exogenous *stimulated* [IL-6] mRNA expression in hepatocytes . Positive_regulation IL6 IL1B 10732314 678307 U46619 augmented *stimulated* [IL-6] and IL-8 mRNA expression within 2 hours of treatment . Positive_regulation IL6 IL1B 10752532 681650 Exposure of HPMC to acetaldehyde , formaldehyde , glyoxal , methylglyoxal , furaldehyde , but not to 5-hydroxymethyl-furfural , resulted in dose dependent inhibition of cell growth , viability , and *stimulated* [IL-6] release ; Positive_regulation IL6 IL1B 10775502 707645 Acute [IL-6] secretion from osteosarcoma cells induced by the PI-linked hormones PTH ( 1-34 ) and endothelin-1 is *potentiated* by . Positive_regulation IL6 IL1B 10807012 692157 *induces* complement component C3 and [IL-6] production at the basolateral and apical membranes in a human intestinal epithelial cell line . Positive_regulation IL6 IL1B 10807012 692158 We tested the hypothesis that *induced* C3 and [IL-6] production is differentially regulated at the apical and basolateral membranes of the enterocyte . Positive_regulation IL6 IL1B 10807012 692160 Stimulation of the Caco-2 cells with *resulted* in increased mRNA levels for C3 and [IL-6] with no major differences noted when the cells were treated at the apical or basolateral membrane . Positive_regulation IL6 IL1B 10833370 697684 [IL-6] transcription and secretion were dose-dependently enhanced by *stimulation* with , tumour necrosis factor (TNF)-alpha , transforming growth factor (TGF)-beta1 and 12-O-tetradecanoyl phorbol-13-acetate ( TPA ) . Positive_regulation IL6 IL1B 10861753 705326 After 4 weeks of treatment with E ( 2 ) + DHT , a significant increase in transcript levels of IL-4 , IL-5 , [IL-6] , MIP-2 , eotaxin , and iNOS was *detected* , while and TNF-alpha transcript levels only increased slightly . Positive_regulation IL6 IL1B 10878380 708976 Also , LPS induced both the and IL-6 genes in normocomplementemic mice , but in complement-deficient mice it significantly *induced* only [IL-6] . Positive_regulation IL6 IL1B 10880263 709117 Blocking protein tyrosine kinase (PTK) activation by herbimycin A or genistein , or blocking NF-kappaB activation by pyrrolidinedithiocarbamate , reduced the [IL-6] expression *induced* by TNF-alpha , and OSM . Positive_regulation IL6 IL1B 10884313 709533 Pretreatment of astrocytes with P2 receptor antagonists , including suramin and periodate oxidized ATP ( oATP ) , resulted in a significant downregulation of *stimulated* expression of nitric oxide , tumor necrosis factor ( TNFalpha ) , and [IL-6] at both the protein and mRNA levels , without affecting cell viability . Positive_regulation IL6 IL1B 10890565 710565 The release of [IL-6] and TNF from the ZG , ZF , ZR , and medulla was *increased* by PDB , IL-1alpha , , and LPS . Positive_regulation IL6 IL1B 10929868 719757 C5a modulation of *induced* [interleukin-6] production by human osteoblast-like cells . Positive_regulation IL6 IL1B 11028561 739588 Geldanamycin , which has been shown in studies to inhibit AP-1 activation , blocked *induced* AP-1 luciferase gene activation and [IL-6] production . Positive_regulation IL6 IL1B 11028561 739590 These results suggest that the AP-1 family of transcription factors is activated by in human enterocytes and that AP-1 may at least in part *regulate* [IL-6] production in these cells . Positive_regulation IL6 IL1B 11048965 743161 The stimulatory effect of PHT on *induced* [IL-6] production was strongly reduced by the specific cyclooxygenase-2 inhibitor NS-398 ( 1 microM ) . Positive_regulation IL6 IL1B 11063815 746835 Incubation with human recombinant IL-1beta ( 100 ng/ml ) also stimulated NO and [IL-6] release to a similar extent to LPS , but ( 1 or 100 ng/ml ) *caused* only modest increases ( approximately seven-fold ) in PGE ( 2 ) release . Positive_regulation IL6 IL1B 11063815 746836 These results indicate that exogenous *induces* release of NO , PGE ( 2 ) and [IL-6] in mixed glial cultures , and that endogenous IL-1beta mediates inflammatory actions of LPS on NO and to a lesser extent IL-6 , but not on PGE ( 2 ) release in mixed glial cultures . Positive_regulation IL6 IL1B 11093146 754950 IL-1L1 did not stimulate IL-6 production from primary human fibroblasts or human umbilical vein endothelial cells nor did it block the IL-1alpha or *dependent* activation of [IL-6] expression . Positive_regulation IL6 IL1B 11109968 757085 significantly *stimulated* trophoblast release of [IL-6] in a dose dependent manner ( 3.3- , 5.5- , 10.3- and 22.4-fold higher compared to the control at 10 , 50 , 100 , 500 U IL-1 beta/ml respectively , p < 0.05 ) . Positive_regulation IL6 IL1B 11120852 758245 Inhibition of C/EBPbeta modestly reduced constitutive and *induced* [IL-6] by RA FLS , but not by human dermal fibroblasts , and had no effect on IL-8 . Positive_regulation IL6 IL1B 11138340 760353 However , E2 increased *induced* [IL-6] production in a dose dependent manner , with a mean 12.5 % increase with 10 ( -8 ) M of E2 ( p = 0.048 ) and 33.4 % with 10 ( -6 ) M ( p < 0.0001 ) versus the control . Positive_regulation IL6 IL1B 11138340 760354 Estrogen up-regulates *induced* [IL-6] production in cultured fibroblast-like synoviocytes , possibly contributing to the enhancement of rheumatoid inflammation in synovial tissues . Positive_regulation IL6 IL1B 11170066 783611 Moreover , recombinant markedly *enhanced* [IL-6] production in glioma cells with a concomitant elevation of its mRNA level . Positive_regulation IL6 IL1B 11170066 783612 Taken together , the results suggest that in HSV1-infection of the CNS , enhancement of [IL-6] production in glial cells is *mediated* not by direct infection to glial cells but rather by released from HSV1 stimulated MNC . Positive_regulation IL6 IL1B 11250916 793779 We hypothesized that and IL-6 induce OT receptor gene expression in human myometrial cells , and this is *mediated* by [NF-IL6] and cognate response elements in the 5'-flanking region of the OT receptor gene . Positive_regulation IL6 IL1B 11268342 764500 depresses peripheral immune responses , *induces* the production of plasma [IL-6] , and stimulates the HPA axis . Positive_regulation IL6 IL1B 11268388 764523 In the rat C6 glioma cell line , synergistically *stimulates* [IL-6] release in the presence of increased intracellular cAMP concentrations . Positive_regulation IL6 IL1B 11268388 764524 The catecholamines and serotonin also synergistically stimulate [IL-6] release in the *presence* of . Positive_regulation IL6 IL1B 11268388 764525 LPC 18 : 0 synergistically increases [IL-6] release in the presence of norepinephrine , and transiently *increases* LPC 18 : 0 formation in C6 cells . Positive_regulation IL6 IL1B 11268388 764526 Therefore , induction of LPC 18 : 0 may *lead* to increases in [IL-6] production via activation of a kinase cascade . Positive_regulation IL6 IL1B 11289656 800570 NS-398 exhibited an inhibition of *induced* [IL-6] production as well as PGE2 production . Positive_regulation IL6 IL1B 11290798 800681 In addition , N-acetylglucosamine also suppresses the production of *induced* cyclooxygenase-2 and [IL-6] . Positive_regulation IL6 IL1B 11327082 807518 IL-1beta and tumor necrosis factor alpha (TNFalpha) , proinflammatory cytokines , induced IL-6 production in a time dependent manner , and PGF2alpha synergistically enhanced [IL-6] production *induced* by and TNFalpha . Positive_regulation IL6 IL1B 11327082 807522 IL-6 mRNA was expressed in PGF2alpha stimulated HGF , and PGF2alpha increased [IL-6] mRNA levels *induced* by and TNFalpha . Positive_regulation IL6 IL1B 11437211 832737 TENS inhibits *induced* synthesis of IL-1beta , [IL-6] , and IL-8 by inhibiting their mRNA expression , and thus significantly suppresses the amplification of IL-1beta induced inflammatory responses in PDL cells . Positive_regulation IL6 IL1B 11446462 835393 Regulatory *role* of in the expression of [IL-6] and IL-8 in human corneal epithelial cells during Pseudomonas aeruginosa colonization . Positive_regulation IL6 IL1B 11478844 842102 These results indicate that PKC-beta ( I ) is a component of the signaling pathway that mediates PTH- , TNF-alpha- , and *stimulated* [IL-6] expression and PTH stimulated bone resorption . Positive_regulation IL6 IL1B 11509008 848231 We examined the effects of physiological and supraphysiological concentrations of 17beta-estradiol ( E2 ) and cortisol on basal and *induced* [IL-6] release in the medium . Positive_regulation IL6 IL1B 11509008 848232 In MG-63 cells , cortisol treatment for 20 h decreased both basal and *induced* [IL-6] release in a dose dependent manner ; Positive_regulation IL6 IL1B 11554696 859900 significantly *induced* [IL-6] mRNA expression and protein secretion , which did not further enhance IL-1beta induced OT secretion . Positive_regulation IL6 IL1B 11576893 865181 Regarding *stimulated* [IL-6] release , there was a small , but not significantly better , response for Bic . Positive_regulation IL6 IL1B 11642733 872252 TGF-beta1 and [IL-6] expression in rat pineal gland is *regulated* by norepinephrine and . Positive_regulation IL6 IL1B 11694623 877129 Furthermore , treatment with long-chain fatty acids significantly enhanced the GRO/CINC-1 and [IL-6] expression that was *induced* by or TGF-beta . Positive_regulation IL6 IL1B 11717194 881914 Ligation of adenosine receptors by adenosine or its related analogue , 2-chloroadenosine ( 2-CADO ) , N ( 6 ) -cyclopentyladenosine (CPA) or CGS21680 synergistically increased *induced* [IL-6] and IL-8 production . Positive_regulation IL6 IL1B 11777983 899873 [IL-6] secretion was rapidly *induced* by IL-17 , , and TNF-alpha . Positive_regulation IL6 IL1B 11792368 901855 We conclude that , unlike *induced* [IL-6] synthesis in astrocytes , the PrP induced IL-6 synthesis in human adult microglia is not PGE2 mediated . Positive_regulation IL6 IL1B 11842936 912366 Indomethacin , a cyclooxygenase inhibitor , significantly enhanced *induced* [IL-6] production by HGF , although it completely inhibited IL-1beta induced PGE2 production . Positive_regulation IL6 IL1B 11842936 912367 Exogenous PGE2 suppressed the *induced* [IL-6] production . Positive_regulation IL6 IL1B 11842936 912369 11-deoxy-PGE1 , a selective EP2/EP3/EP4 agonist , and butaprost , a selective EP2 agonist , inhibited *induced* [IL-6] production , although butaprost was less potent than 11-deoxy-PGE1 . Positive_regulation IL6 IL1B 11842936 912370 17-phenyl-omega-trinor PGE2 , an EP1 agonist , enhanced *induced* [IL-6] production . Positive_regulation IL6 IL1B 11842936 912373 Based on these data , we suggest that PGE2 can up- or downregulate *induced* [IL-6] production via EP1 receptors or via EP2/EP4 receptors in HGF , respectively . Positive_regulation IL6 IL1B 11872267 918548 The production of TNF-alpha and [IL-6] was *induced* by and Abeta [ 25-35 ] and synergistically amplified by the co-stimulation of IL-1beta and Abeta [ 25-35 ] . Positive_regulation IL6 IL1B 11950021 930275 CELE and IBUP only inhibited *stimulated* [IL-6] production ; Positive_regulation IL6 IL1B 12010575 941240 Reporter gene assays in immortalized chondrocytes , C-20/A4 , consistently showed increased sIL-1Ra promoter activity in *response* to and [IL-6] . Positive_regulation IL6 IL1B 12034569 948783 However , *induced* proliferation and expression of [IL-6] are significantly higher in Thy-1- fibroblasts . Positive_regulation IL6 IL1B 12045890 895169 The *role* of in the regulation of IL-8 and [IL-6] in human corneal epithelial cells during Pseudomonas aeruginosa colonization . Positive_regulation IL6 IL1B 12045890 895173 The purpose of this study was to investigate whether *regulates* the expression of [IL-6] and IL-8 in human corneal epithelial cells during Pseudomonas aeruginosa colonization . Positive_regulation IL6 IL1B 12130681 966603 Similar to dexamethasone , A276575 exhibited high affinity for GR and potently repressed *stimulated* [IL-6] production in human skin fibroblasts , prostaglandin ( PG ) E ( 2 ) production in A549 human lung epithelial cells , and concanavalin A-induced monocyte proliferation . Positive_regulation IL6 IL1B 12190816 980014 *induces* [interleukin-6] mRNA expression and protein production in synovial cells from human temporomandibular joint . Positive_regulation IL6 IL1B 12190816 980015 *increased* [IL-6] production in HTS cells . Positive_regulation IL6 IL1B 12190816 980016 also *stimulated* [IL-6] mRNA expression . Positive_regulation IL6 IL1B 12190816 980017 *increased* [IL-6] production in synovial cells resulting from an increase in IL-6 mRNA expression . Positive_regulation IL6 IL1B 12215492 986079 On the other hand , PPAR-gamma ligands troglitazone , pioglitazone , and 15-deoxy-Delta ( 12,14 ) -prostaglandin J ( 2 ) inhibited *induced* [IL-6] expression at a transcriptional revel in VSMCs . Positive_regulation IL6 IL1B 12219016 986621 IL-10 potentiated *induced* [IL-6] promoter activity . Positive_regulation IL6 IL1B 12233876 988782 Androgen receptors in human synoviocytes and androgen regulation of *induced* [IL-6] production : a link between hypoandrogenicity and rheumatoid arthritis ? Positive_regulation IL6 IL1B 12241537 989693 *increased* NF-kappaB DNA binding activity , [IL-6] mRNA levels and IL-6 production . Positive_regulation IL6 IL1B 12421347 1013465 In comparison , *induced* the release of PGE2 , [IL-6] and activated NF-kappaB , p38 , JNK and ERK1/2 in mixed glial cultures , but failed to induce any of these responses in microglial cell cultures . Positive_regulation IL6 IL1B 12421347 1013469 Interestingly , a neutralizing antibody to IL-1RII significantly increased the concentration of IL-1beta in the medium of LPS treated microglia and exacerbated the *induced* [IL-6] release in mixed glia , providing the first evidence that microglial IL-1RII regulates IL-1beta actions by binding excess levels of this cytokine during brain inflammation . Positive_regulation IL6 IL1B 12424420 1014182 The *induced* [IL-6/IL-8] release of HPMC from healthy donors and from patients with end-stage renal disease ( ESRD ) were measured before the start of chronic peritoneal dialysis ( PD ) and during PD therapy . Positive_regulation IL6 IL1B 12527330 1048282 *increased* [IL-6] , IL-8 , MIP-1beta , NO , PGE ( 2 ) and MMP-3 productions , but inhibited AGG and TIMP-1 synthesis . Positive_regulation IL6 IL1B 12568957 1057193 *induces* COX2 , MMP-1 , -3 and -13 , ADAMTS-4 , IL-1 beta and [IL-6] in human tendon cells . Positive_regulation IL6 IL1B 12569227 1057247 Plasma [interleukin (IL)-6] , IL-8 , IL-10 , granulocyte colony stimulating factor ( G-CSF ) , macrophage CSF (M-CSF) , and monocyte chemotactic protein 1 (MCP-1) increased significantly after the race , and urine , IL-6 , G-CSF , M-CSF , and MCP-1 *increased* significantly . Positive_regulation IL6 IL1B 12667656 1075627 Both IL-17 and *induced* [IL-6] production by normal myoblasts and muscle samples . Positive_regulation IL6 IL1B 12668157 1075704 *Stimulation* of [interleukin-6] release by from isolated human adipocytes . Positive_regulation IL6 IL1B 12668157 1075710 , however , *induced* a substantial increase in [IL-6] release in adipocytes and PBC ( all p < 0.05 ) . Positive_regulation IL6 IL1B 12676746 1076833 *stimulates* [IL-6] production in cultured skeletal muscle cells through activation of MAP kinase signaling pathway and NF-kappa B . Positive_regulation IL6 IL1B 12676746 1076850 We tested the hypothesis that [IL-6] production in muscle cells is *regulated* by and that mitogen activated protein (MAP) kinase signaling and NF-kappaB activation are involved in IL-1beta induced IL-6 production . Positive_regulation IL6 IL1B 12727980 1086549 Whereas *increased* the production of [IL-6] , IL-8 , and monocyte chemotactic protein-1 , and expression of cyclooxygenase-2 mRNA in ESC cultured without treatment , the stimulatory effects of IL-1 beta were reduced in the decidualized cells . Positive_regulation IL6 IL1B 12746307 1088757 *induced* a moderate increase in plasma levels of [IL-6] that was suppressed by ovarian hormone replacement . Positive_regulation IL6 IL1B 12774928 1095361 Levels of [IL-6] and G-CSF were elevated during the active phase , but the level of did not *increase* . Positive_regulation IL6 IL1B 12781209 1095635 This study determined myrrh oil ( MO ) cytotoxicity to human gingival fibroblasts and epithelial cells and its effect , measured by ELISA , on *stimulated* [IL-6] and IL-8 production . Positive_regulation IL6 IL1B 12781209 1095637 There was little or no detectable *stimulated* production of [IL-6] or IL-8 by cells exposed to > /=0.0025 % MO , probably reflective of loss of viability . Positive_regulation IL6 IL1B 12781209 1095639 At subtoxic MO levels ( 0.00001-0.001 % ) , there was a significant reduction of *stimulated* [IL-6] and IL-8 production by fibroblasts , but not by epithelial cells . Positive_regulation IL6 IL1B 12799018 1100965 *induced* release of [IL-6] and activated NFkappaB , p38 , JNK and ERK1/2 in mixed glial cultures , which was completely abolished in the presence of IL-1 receptor antagonist (IL-1ra) . Positive_regulation IL6 IL1B 12824917 1104405 Exogenous *enhanced* expression of various cytokines ( [IL-6] , IL-8 , and vascular endothelial growth factor ( VEGF ) ) and intracellular adhesion molecule-1 ( ICAM-1 ) by A549 , PC14 , RERF-LC-AI , and SBC-3 cells expressing IL-1 receptors . Positive_regulation IL6 IL1B 12873439 1114297 *increased* [IL-6] when combined with TNF-alpha ( P < 0.05 ) . Positive_regulation IL6 IL1B 12873450 1114303 The objective of the study was to investigate the effects of baicalin , baicalein , and wogonin ( plant flavonoids ) on [interleukin-6 (IL-6)] and interleukin-8 (IL-8) protein production , mRNA expression , and nuclear factor-kappaB (NF-kappaB) binding activities *induced* by in human retinal pigment epithelial cell line ( ARPE-19 ) cells . Positive_regulation IL6 IL1B 12873450 1114330 Baicalin did not suppress *induced* [IL-6] and IL-8 production , but dexamethasone , baicalein , and wogonin , significantly suppressed IL-6 and IL-8 production . Positive_regulation IL6 IL1B 12873450 1114332 Wogonin and baicalein inhibited *induced* [IL-6] and IL-8 mRNA and protein production in ARPE-19 cells . Positive_regulation IL6 IL1B 12880609 1115757 stimulation *increased* [IL-6] and IL-8 , but did not affect IL-4 and IL-10 production . Positive_regulation IL6 IL1B 1311232 178762 Similarly , *potentiated* [IL-6] release stimulated by forskolin and ( Bu ) 2cAMP . Positive_regulation IL6 IL1B 1311232 178764 Thus , the adrenal may be an important convergence point between the immune and endocrine systems , and because [IL-6] release is *regulated* by IL-1 alpha , , ACTH , and angiotensin II , and this cytokine stimulates corticosterone release , IL-6 may play an important paracrine role in integrating the signals derived from these systems . Positive_regulation IL6 IL1B 1330001 200112 In these cell lines the degree of tumorigenicity was inversely correlated with [IL-6] *induction* by . Positive_regulation IL6 IL1B 1330001 200113 The less transformed cell lines produced lower yields of *induced* [IL-6] , dependent on their degrees of transformation and tumorigenicity . Positive_regulation IL6 IL1B 1335554 206052 Some of the peripheral effects of IL-1 beta appear to be related to the secretion of [IL-6] *induced* by . Positive_regulation IL6 IL1B 1386759 193389 Recombinant interleukin-1 receptor antagonist blocked the interleukin-1 mRNA as well as [interleukin-6] and interleukin-8 mRNA accumulation *induced* by . Positive_regulation IL6 IL1B 1402392 199579 Tumor cell [IL-6] gene expression is *regulated* by and TNF alpha : proposed feedback mechanisms induced by the interaction of tumor cells and macrophages . Positive_regulation IL6 IL1B 1417523 201632 The finding that [IL-6] is produced by PDL cells and is *regulated* by has revealed a potentially important mechanism for controlling alveolar bone resorption . Positive_regulation IL6 IL1B 1431212 202866 Unstimulated HDMEC did not produce significant amounts of IL-6 , whereas lipopolysaccharide (LPS) , TNF , and were potent *inducers* of HDMEC derived [IL-6] production . Positive_regulation IL6 IL1B 1431212 202868 stimulation *resulted* in pronounced [IL-6] production after 4 h , followed by complete downregulation at the transcriptional level after 24 h . Positive_regulation IL6 IL1B 1431212 202871 The effects of hydrocortisone , dexamethasone , calcitriol , acitretin , and cyclosporin A on TNF- or *induced* [IL-6] production by HDMEC were determined by ELISA . Positive_regulation IL6 IL1B 14563491 1154853 Our previous studies indicated that non-antimicrobial chemically modified tetracyclines ( CMTs ) can dose-dependently inhibit *induced* [IL-6] secretion in osteoblastic cells . Positive_regulation IL6 IL1B 14563491 1154854 CMT-8 regulation of *induced* [IL-6] gene expression was further explored . Positive_regulation IL6 IL1B 14563491 1154881 These data suggest that CMT-8 can modulate inhibit *induced* [IL-6] expression in MC3T3-E1 cells at the post-transcriptional level affecting IL-6 mRNA stability . Positive_regulation IL6 IL1B 14585831 1187143 Instead , *induced* [IL-6] gene expression was greatly suppressed in sek1 ( -/- ) mkk7 ( -/- ) fibroblasts . Positive_regulation IL6 IL1B 14617515 1200647 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL6 IL1B 14630536 1170467 Six hours after irradiation , levels had increased in the hypothalamus , thalamus and hippocampus , and TNFalpha and [IL-6] levels had *increased* significantly in the hypothalamus . Positive_regulation IL6 IL1B 14659542 1177384 Pretreatment with anti-Toll-like receptor 2 (TLR2) antibody significantly inhibited , TNF-alpha and [IL-6] *induction* ( P < 0.05 ) in mouse macrophages and pit forming activity of osteoclast precursor cells stimulated with P. gingivalis 67-kDa minor fimbriae . Positive_regulation IL6 IL1B 14659593 1177388 The stress mediated induction of , interleukin-6 , and interleukin-10 ( IL-1beta , IL-6 , and IL-10 ) in the circulating blood tended to be higher with aging in both CLP and LPS models , and in particular , the induction of [IL-6] was significantly *augmented* with aging . Positive_regulation IL6 IL1B 14670800 1210948 Constitutive or *induced* IL-8 or [IL-6] secretion or nuclear factor-kappaB activity was not significantly different between non-CF and CF cells . Positive_regulation IL6 IL1B 14730602 1198944 However , Rb overexpression had no effect on spontaneous or *induced* production of [IL-6] or MMP-1 in non-RA synovial fibroblasts . Positive_regulation IL6 IL1B 14764742 1207410 Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through *induced* [IL-6] expression . Positive_regulation IL6 IL1B 14764742 1207411 These novel findings indicate that soluble IL-1beta bioactivity and autocrine *dependent* [IL-6] up-regulation are critical initiators of fibroblast activation and proliferation and that they likely play a role in the fibroproliferative response seen in human acute lung injury . Positive_regulation IL6 IL1B 1478679 207507 Expression and generation of interleukin-8 , [IL-6] and granulocyte-macrophage colony stimulating factor by bronchial epithelial cells and *enhancement* by and tumour necrosis factor-alpha . Positive_regulation IL6 IL1B 14974816 1182741 Cyclooxygenase-2 inhibitors decrease *stimulated* prostaglandin E2 and [IL-6] production by human gingival fibroblasts . Positive_regulation IL6 IL1B 14974816 1182742 The selective COX-2 inhibitors , but not indomethacin , caused partial ( generally up to approximately 60 % ) , dose dependent decreases in *stimulated* [IL-6] in all cell lines ( P < or = 0.003 ) . Positive_regulation IL6 IL1B 15000862 1216964 Lipoxin A4 ( LXA4 ) and transforming growth factor beta 2 ( TGF-beta 2 ) , mediators with potential anti-inflammatory activities , were tested to determine how they affect *dependent* release of [IL-6] and MMPs in human fibroblast like synoviocytes . Positive_regulation IL6 IL1B 15076648 1233022 Twenty-four hours after exposure to 500 microg/m3 , nasal secretion levels of *increased* 72.3 % ( 0-150.2 % , P=0.002 ) , levels of [IL-6] increased 42.2 % ( -28-161.9 % , P=0.01 ) , and levels of IL-8 increased 19.7 % ( -20.3-60.5 % , P=0.03 ; median and 95 % confidence interval ) . Positive_regulation IL6 IL1B 15103492 1258355 Similarly , *induced* [IL-6] production was greater in pediatric PMs compared with adults ( 532+/-3 vs. 444+/-52 , P < 0.05 ) . Positive_regulation IL6 IL1B 15103492 1258358 In conclusion , *induced* [IL-6] and TNFalpha production were greater in pediatric than adult PMs . Positive_regulation IL6 IL1B 15186945 1256278 Pre-incubation of HAEC with AEM at 20 and 40 microg/ml , but not at 4 microg/ml , for 24h significantly suppressed *stimulated* expressions of intracellular adhesion molecule-1 ( ICAM-1 ) , vascular cell adhesion molecule-1 ( VCAM-1 ) , and E-selectin and the secretion of proinflammatory cytokines [IL-6] , chemokines IL-8 and monocyte chemoattractant protein (MCP)-1 . Positive_regulation IL6 IL1B 15195698 1260165 p38 MAPK regulates *induced* [IL-6] expression through mRNA stability in osteoblasts . Positive_regulation IL6 IL1B 15195698 1260234 These results indicate that p38 MAPK regulates *stimulated* [IL-6] at a post transcriptional mechanism and one of the primary targets of IL-6 gene regulation is the 3'UTR of IL-6 . Positive_regulation IL6 IL1B 1527383 197555 Finally , plus TNF-alpha *induced* the production of [IL-6] , but not of Ig , by adherent BM cells . Positive_regulation IL6 IL1B 1527383 197559 These results suggest that and TNF-alpha produced by adherent BM cells synergistically *induce* early [IL-6] generation , which , in turn , drives BM B cell producers into the high rate Ig-secreting state . Positive_regulation IL6 IL1B 15316244 1286184 Somatostatin and gamma-aminobutyric acid inhibit *stimulated* release of [interleukin-6] from rat C6 glioma cells . Positive_regulation IL6 IL1B 15316244 1286185 We investigated the ability of inhibitory neurotransmitters to alter the *stimulated* release of [interleukin-6 (IL-6)] from cultured glial tumor cells . Positive_regulation IL6 IL1B 15316244 1286186 *promoted* the release of [IL-6] with a maximally effective concentration of 25 ng/ml . Positive_regulation IL6 IL1B 15316244 1286187 and LPC synergistically *enhanced* release of [IL-6] in the presence of the beta-adrenergic receptor agonist isoproterenol ( ISO ) ; Positive_regulation IL6 IL1B 15373762 1297875 *induced* expression of [IL-6] and production of human chorionic gonadotropin in human trophoblast cells via nuclear factor-kappaB activation . Positive_regulation IL6 IL1B 15373762 1297876 The purpose of this study was to examine the role of nuclear factor-kappaB (NF-kappaB) during the *induction* of [IL-6] by in human trophoblast cells . Positive_regulation IL6 IL1B 15373762 1297880 The addition of TPCK reduced the *induced* [IL-6] expression . Positive_regulation IL6 IL1B 15383152 1304180 However , [IL-6] , IL-8 , and IL-13 production *induced* by were significantly enhanced by addition of epinephrine . Positive_regulation IL6 IL1B 15450530 1300743 highly *stimulated* *NO , IL-8 , [IL-6] , MIP-1beta and PGE ( 2 ) synthesis but decreased AGG and TGF-beta1 production . Positive_regulation IL6 IL1B 15455248 1374730 In the CSF , the level increased from 55.71+/-72.79 pg/ml at T1 to 106.10+/-142.12 pg/ml at T2 and the [IL-6] level *increased* from 405.43+/-280.28 pg/ml at T1 to 631.57+/-385.35 pg/ml at T2 ; Positive_regulation IL6 IL1B 15550066 1338537 Effects of PD98059 , SB202190 and SP600125 ( inhibitors of ERK , p38 and JNK , respectively ) on *induced* secretion of [IL-6] and IL-8 , and on IL-1beta induced expression of cyclo-oxygenase-2 (COX-2) in endometriotic cells were studied . Positive_regulation IL6 IL1B 15550066 1338541 Both SB202190 and SP600125 suppressed *induced* secretion of [IL-6] and IL-8 , and PD98059 suppressed IL-1beta induced secretion of IL-8 . Positive_regulation IL6 IL1B 15618163 1357616 Expression of proinflammatory cytokines , such as [interleukin-6 (IL-6)] and IL-8 , was also *induced* significantly in both cell types by the Msps , as determined by reverse transcription-PCR and an enzyme linked immunosorbent assay , whereas synthesis could be detected only in the THP-1 cells . Positive_regulation IL6 IL1B 15652448 1364225 We comprehensively investigated the involvement of mitogen activated protein kinases ( MAPKs ) /activator protein-1 (AP-1) and IkappaB kinases ( IKKs ) /IkappaBs/nuclear factor-kappaB (NF-kappaB) in *stimulated* [IL-6] , IL-8 , prostaglandin E ( 2 ) ( PGE ( 2 ) ) and matrix metalloproteinase-1 (MMP-1) production by human gingival fibroblasts (HGF) . Positive_regulation IL6 IL1B 15652990 1364384 Activation of metabotropic glutamate receptor 3 enhances *stimulated* release of [IL-6] in cultured human astrocytes . Positive_regulation IL6 IL1B 15652990 1364386 Activation of mGluR3 with DCG-IV ( but not of mGluR5 with DHPG ) enhanced , in the *presence* of , the release of [IL-6] in a dose dependent manner in astrocytes cultured under conditions ( +EGF ) in which the mGluR expression is known to be upregulated . Positive_regulation IL6 IL1B 15652990 1364388 The capacity of mGluR3 to modulate the release of [IL-6] in the *presence* of supports the possible involvement of this receptor subtype in the regulation of the inflammatory and immune response under pathological conditions associated with glial cell activation . Positive_regulation IL6 IL1B 15655672 1375890 Although treatment with Hsp72 or Hsp60 alone did not significantly affect basal IL-6 release into culture medium statistically , cotreatment with IL-1beta and Hsp72 , but not Hsp60 or boiled Hsp72 , decreased *induced* [IL-6] production in culture medium . Positive_regulation IL6 IL1B 15655672 1375891 Introduction of Hsp72 , but not Hsp60 , into VSMCs decreased *induced* [IL-6] production in culture medium . Positive_regulation IL6 IL1B 15665043 1402417 Consistent with the increase in IL-1R1 expression , OSM markedly augmented *induced* VEGF , MCP-1 , and [IL-6] release . Positive_regulation IL6 IL1B 15731288 1439208 TNFalpha and *induced* [IL6] production by normal muscle samples and myoblasts , the action of TNFalpha being more potent on muscle samples . Positive_regulation IL6 IL1B 15749024 1379453 Recombinant mouse *induced* strong activation of ERK1/2 , p38 , JNK and NFkappa B , and significant release of [IL-6] and PGE2 , which was blocked by IL-1ra . Positive_regulation IL6 IL1B 15762036 1352560 After 24 h incubation with 10 ( -8 ) M concentration of these compounds , there was no decrease in : a ) the constitutive or *induced* levels of [IL-6] protein released to culture medium ; Positive_regulation IL6 IL1B 15778394 1385090 Furthermore , *induced* IL-8 , [IL-6] , and matrix metalloproteinase-3 protein production was significantly inhibited in DN MKK3/DN MKK6 transfected cells . Positive_regulation IL6 IL1B 15828923 1394271 *induced* IL-8 and [IL-6] secretion was significantly decreased after granulocyte/monocyte adsorptive apheresis . Positive_regulation IL6 IL1B 15889405 1426619 Finally , we confirmed that LPS dramatically increased IL-1beta , and *dependent* [IL-6] levels in the culture medium for 2 days before returning to baseline . Positive_regulation IL6 IL1B 15896421 1407980 *increased* the production of IL-8 and [IL-6] ( P < 0.01 ) . Positive_regulation IL6 IL1B 15905624 1409398 Only the highest concentration of inhibin B ( 10 ( -8 ) M ) reduced IL-6 secretion by EEC , but did not modulate *induced* stimulation of [IL-6] secretion . Positive_regulation IL6 IL1B 16002736 1431018 *induces* [IL-6] expression in human orbital fibroblasts : identification of an anatomic-site specific phenotypic attribute relevant to thyroid associated ophthalmopathy . Positive_regulation IL6 IL1B 16024789 1435413 Overexpression of IRAK1c suppressed NF-kappaB activation and blocked *induced* [IL-6] as well as lipopolysaccharide- and CpG induced tumor necrosis factor alpha production in multiple cellular systems . Positive_regulation IL6 IL1B 16095565 1448119 Furthermore , *stimulated* [IL-6] promoter activity in the osteoblastic cell line MC3T3-E1 stably transfected with a human IL-6 promoter/luciferase construct , and both VIP , and the related neuropeptide PACAP-38 , increased the effect of IL-1beta in a synergistic manner . Positive_regulation IL6 IL1B 16109400 1448474 Use of the nitric oxide releaser DETA/NO ( 2,2'- ( hydroxynitrosohydrazono ) bis-ethanimine ) demonstrated that nitric oxide does not inhibit *induced* [interleukin-6] secretion . Positive_regulation IL6 IL1B 16112536 1507296 The data suggest that gingival epithelial cells and fibroblasts may differ in the magnitude of NF-kappaB activation after IL-1beta stimulation , and that MO inhibition of *stimulated* [IL-6] production in fibroblasts is due in part to inhibition of PGE ( 2 ) , but not NF-kappaB activation . Positive_regulation IL6 IL1B 16175346 1461825 TNF-alpha and are early regulators of the immune response and both *induce* the release of secondary cytokines , such as [IL-6] and IL-8 . Positive_regulation IL6 IL1B 16198622 1496327 Although *induces* [IL-6] production in hepatocytes , our data indicate that the effect of IL-1beta on hepcidin expression is independent from that of IL-6 . Positive_regulation IL6 IL1B 16214025 1464759 *activates* [IL-6] , and both cytokines are produced by peripheral blood mononuclear cells . Positive_regulation IL6 IL1B 16354624 1492630 *stimulated* [IL-6] , IL-8 , and MCP-1 mRNA expression and protein levels . Positive_regulation IL6 IL1B 16375968 1547163 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL6 IL1B 16377203 1494051 The mechanism by which *promoted* [IL-6] expression in CB-MSCs was studied . Positive_regulation IL6 IL1B 16407046 1513301 We investigated whether HDSMCs are capable of expressing and releasing MCP-1 , [IL-6] and SCF in *response* to IL-4 , IL-13 , and tumor necrosis factor-alpha . Positive_regulation IL6 IL1B 16413378 1513959 TNF-alpha and ( 0.01 to 100 ng/mL ) *induced* secretion of IL-8 , [IL-6] , and RANTES in a dose and time dependent manner . Positive_regulation IL6 IL1B 16435581 1495237 When added to HGFs , *had* a stimulatory effect on the production of [IL-6] , and this effect was significantly reduced by SB203580 , a specific p38 MAPK inhibitor . Positive_regulation IL6 IL1B 16435581 1495296 These results strongly suggest that both p38 MAPK and NF-kappaB are required in *induced* [IL-6] synthesis and that these two IL-1beta activated pathways can be primarily dissociated . Positive_regulation IL6 IL1B 1644898 194906 These results suggest that TNF-alpha and *activate* [IL-6] gene expression in astrocytes by a mechanism ( s ) involving activation of an NF-kappa B-like protein . Positive_regulation IL6 IL1B 1649133 160901 These results suggest that IL-1 has differing effects on the release of mediators by synovial cells and chondrocytes and that these cells also vary in their *responses* to and [IL-6] . Positive_regulation IL6 IL1B 16507601 1581852 consistently , *induction* of [IL-6] by TNF-alpha or was much more robust in VDR-/- than in VDR+/- cells , indicating that VDR-/- cells are more susceptible to inflammatory stimulation . Positive_regulation IL6 IL1B 16601113 1568700 Overexpression of GSK-3beta in endothelial cells , in contrast , significantly inhibited ( by 70 % , p < 0.01 ) both TNF-alpha and *induced* expression of [IL-6] , MCP-1 , and vascular cell adhesion molecule-1 . Positive_regulation IL6 IL1B 16601138 1568719 The effects of adiponectin on *induced* secretion of [IL-6] , IL-8 , and monocyte chemoattractant protein 1 from cultured ESCs were determined using specific ELISAs . Positive_regulation IL6 IL1B 16601138 1568725 Adiponectin decreased *induced* secretion of [IL-6] , IL-8 , and monocyte chemoattractant protein 1 from ESCs . Positive_regulation IL6 IL1B 16616208 1582992 The expression of [IL-6] and IL-11 increased greatly in the *presence* of on day 1 and after day 14 of culture . Positive_regulation IL6 IL1B 1675538 158020 These results demonstrate that enhancement of keratinocyte bound [IL-6] does not *induce* TNF alpha , or IL-6 expression by LC during APR or IPR , and that enhanced keratinocyte expression of IL-6 fails to distinguish between these two reactions . Positive_regulation IL6 IL1B 16807360 1612761 In circular muscle , exogenous PAF *induced* sequential formation of [IL-6] , H ( 2 ) O ( 2 ) , , and PAF . Positive_regulation IL6 IL1B 16936090 1608915 Lipopolysaccharide (LPS) *induced* the release of the proinflammatory cytokine [IL-6] and that of the chemokines G-CSF , MCP-1 , MIP-1beta , and IL-8 as well as surface expression of ICAM-1 by corneal fibroblasts , whereas , TNF-alpha , and GM-CSF were not detected in the culture supernatants of cells incubated with or without LPS . Positive_regulation IL6 IL1B 17005253 1666314 In contrast , both and TNFalpha highly *induced* [IL-6] secretion in chorion derived cells , demonstrating the overall responsiveness of these cells to these stimuli . Positive_regulation IL6 IL1B 17012372 1674160 TNF-alpha and *increased* [IL-6] and IL-8 12- to 67-fold with higher levels in IB3 than C38 cells post-TNF-alpha ( P < 0.05 ) . Positive_regulation IL6 IL1B 17022949 1641526 Relative to saline administration , *increased* IL1beta , TNFalpha and [IL6] mRNAs in the nucleus tractus solitarius (NTS) , hypothalamus , hippocampus and somatosensory cortex ( SSctx ) , but did not induce any changes in IL10 . Positive_regulation IL6 IL1B 17024100 1674281 *Induction* of [IL-6] by peptide and stimulation by IL-6 peptide in NFs , or inhibition of IL-6 or IL-6R alpha in KFs cultures demonstrated a dose dependent increase or decrease in procollagen I synthesis , respectively . Positive_regulation IL6 IL1B 17077666 1642384 In contrast , Dex treatment inhibited the *induced* production of GM-CSF , [IL-6] , IL-8 , MCP-3 , and RANTES , but not MCP-1 . Positive_regulation IL6 IL1B 17201586 1663171 Exogenous *induces* its own expression , but not that of [IL-6] in the hypothalamus and activates HPA axis and prolactin release . Positive_regulation IL6 IL1B 17298882 1711216 Consistently , *induction* of [IL-6] by TNFalpha or was much more robust in VDR ( -/- ) than in VDR ( +/- ) cells , indicating that VDR ( -/- ) cells are more susceptible to inflammatory stimulation . Positive_regulation IL6 IL1B 1730872 181325 By using mAb alpha-IL-1 beta we showed that IL-2 induced [IL-6] production is not *mediated* by the autocrine stimulation of elicited by IL-2 . Positive_regulation IL6 IL1B 1730872 181329 In contrast , IFN-gamma could completely abrogate the *induction* of [IL-6] expression by but did not affect the levels of mRNA and the secretion of IL-2 elicited IL-6 . Positive_regulation IL6 IL1B 17335379 1707615 PGE ( 2 ) and the transcription factor nuclear factor-kappa B (NF-kappaB) regulate *stimulated* [IL-6] production . Positive_regulation IL6 IL1B 17395587 1741884 Salmeterol and salbutamol enhanced rhinovirus- and *induced* [IL-6] production ; Positive_regulation IL6 IL1B 17395587 1741885 Combined activity of salmeterol and fluticasone at equimolar concentrations had no effect on rhinovirus or *induction* of [IL-6] . Positive_regulation IL6 IL1B 17482186 1848297 Addition of soluble IL-1RII ( 2.0 microg/mL ) significantly inhibited *induced* [IL-6] and IL-8 secretion by endometrial cells in vitro . Positive_regulation IL6 IL1B 17669273 1776997 An anti-peptide-4 antibody which targets domain III inhibited 70 % of *induced* productions of [IL-6] and PGE ( 2 ) from 3T3-L1 cells . Positive_regulation IL6 IL1B 17881510 1823683 We found that IL-33 , but not or IL-18 , *induced* IL-13 and [IL-6] production by mouse bone marrow derived , cultured mast cells ( BMCMCs ) independently of IgE . Positive_regulation IL6 IL1B 17881510 1823692 In BMCMCs incubated with the potently cytokinergic SPE-7 IgE without specific antigen , IL-33 , , and IL-18 each *promoted* IL-13 and [IL-6] production , but the effects of IL-33 were more potent than those of IL-1beta or IL-18 . Positive_regulation IL6 IL1B 17920534 1804179 While SA981 partially inhibited IL-1beta induced VEGF production at concentrations of 10 to 100 microM ( 10.1 % and 14.2 % inhibition of total VEGF production under IL-1beta coexistence condition , respectively ) , it failed to inhibit *induced* [IL-6] production at the same concentrations . Positive_regulation IL6 IL1B 1792940 176132 *increased* [IL-6] mRNA levels , maximally 40-fold at 12 h . IL-1 beta increased IL-6 secretion to 0.13 nM , more than 80-fold that of untreated controls at 12 h . IL-1 beta also increased IL-1 beta mRNA levels , maximally 9-fold at 12 h , but did not increase cellular levels or secretion of IL-1 beta protein . Positive_regulation IL6 IL1B 18025214 1827701 In this study , it was demonstrated that LL-37 synergistically enhanced the *induced* production of cytokines ( [IL-6] , IL-10 ) and chemokines such as macrophage chemoattractant proteins ( MCP-1 , MCP-3 ) in human PBMC , indicating a role in enhancing certain innate immune responses . Positive_regulation IL6 IL1B 18262272 1884937 *induced* [IL-6-synthesis] in PHH but not in Hep3B-cells . Positive_regulation IL6 IL1B 18262272 1884939 C/EBPbeta-overexpression in Hep3B-cells reconstituted mediated [IL-6/CRP] *inducibility* . Positive_regulation IL6 IL1B 1837029 175086 [Interleukin-6] induction by FcRI stimulation is not *mediated* solely by FcRI induced M phi tumor necrosis factor alpha , IL-1 alpha , or production and is independent of M phi prostaglandin E2 levels . Positive_regulation IL6 IL1B 18400310 1913499 the addition of sIL-6R , binding to *induced* [IL-6] , greatly increases IL-6 production . Positive_regulation IL6 IL1B 18434191 1920801 Here we demonstrate that , whilst *induced* significant synthesis of [IL-6] in neurones , IL-1alpha had no effect . Positive_regulation IL6 IL1B 18434191 1920802 Whilst *induced* [IL-6] synthesis was dependent on the nSMase/Src kinase signalling cascade , specific inhibitors of nSMase ( 3-OMS ) and Src kinase ( PP2 ) failed to inhibit IL-1alpha- and IL-1beta induced chemokines synthesis , suggesting the existence of alternative signalling pathway ( s ) in neurones . Positive_regulation IL6 IL1B 18502965 1917763 Constitutive mRNA expression of IL-6 , IL-11 , and leukemia inhibitory factor (LIF) , but not of oncostatin M (OSM) , was demonstrated , as was concentration dependent *stimulation* of [IL-6] and LIF mRNA and of protein by and TNF-alpha . Positive_regulation IL6 IL1B 18565769 1984272 In the *presence* of , FGF-18 increased expression of ADAMTS-4 , aggrecan , BMP-2 , COL2A1 , CCL3 , CCL4 , CCL20 , CXCL1 , CXCL3 , CXCL6 , IL-1beta , [IL-6] , and IL-8 and decreased ADAMTS-5 , MMP-13 , CCL2 , and CCL8 . Positive_regulation IL6 IL1B 18586957 1953588 This finding is consistent with the observation that *induced* expression of [IL-6] , a known NF-kappaB dependent gene in ASM , was also unaffected by beta(2)-adrenoceptor agonists , forskolin , PGE ( 2 ) , 8-bromo-cAMP , or rolipram . Positive_regulation IL6 IL1B 18784630 1969248 In addition , IL-6 secretion from AF cells in response to TNF-alpha was up-regulated by coculture , however , [IL-6] secretion in *response* to was downregulated in a dose dependent manner . Positive_regulation IL6 IL1B 18786965 1976031 On the other hand , TNF-alpha and IL-17 did not induce RANKL expression , although TNF-alpha , IL-17 or *stimulated* cell growth and [IL-6] production . Positive_regulation IL6 IL1B 18796608 1969435 We found that epigallocatechin-3-gallate ( EGCG ) , an anti-inflammatory compound found in green tea , inhibits *induced* [IL-6] production and transsignaling in RA synovial fibroblasts by inducing alternative splicing of gp130 mRNA , resulting in enhanced sgp130 production . Positive_regulation IL6 IL1B 19117935 2060759 also *induced* MCP-1 , [IL-6] , and IL-8 more vigorously in TAO derived fibroblasts . Positive_regulation IL6 IL1B 1918169 168386 In the present study , we show that [IL-6] production by AML blasts is *up-regulated* by endogenously produced . Positive_regulation IL6 IL1B 1940439 170606 Moreover , an anti-rhIL-6 antibody , which effectively neutralized the fibroblast stimulating activities of rhIL-6 , only fractionally blocked the fibroblast stimulating actions of rhIL-1 beta , suggesting autocrine [IL-6] only partially *mediates* the effects of on fibroblasts . Positive_regulation IL6 IL1B 19406240 2095654 In PC-3 cells , *stimulated* [IL-6] and OPG release , and dexamethasone dose-dependently inhibited IL-1beta-inducible IL-6 release , and constitutive and IL-1beta-inducible OPG release . Positive_regulation IL6 IL1B 19523846 2109025 Scabies inhibited the IL-1alpha and *induced* secretion of [IL-6] , while a combination of scabies and histamine or LTB4 reduced the TNFalpha induced secretion of IL-6 . Positive_regulation IL6 IL1B 1954875 172448 The PLA2 inhibitor aristolochic acid ( 10 microM ) blocked *induced* [IL-6] release and the release of IL-6 caused by Pyrularia pubera thionin ( 5 micrograms/ml ) , a stimulator of PLA2 activity . Positive_regulation IL6 IL1B 1954875 172450 The cyclooxygenase inhibitor indomethacin ( 10 microM ) did not inhibit *induced* [IL-6] release . Positive_regulation IL6 IL1B 1954875 172452 In contrast , the general lipoxygenase inhibitor nordihydroguaiaretic acid ( 10 microM ) and the more specific 5-lipoxygenase inhibitors AA861 and RHC5901 ( both 10 microM ) reduced basal and blocked *induced* [IL-6-release] . Positive_regulation IL6 IL1B 19580863 2142569 *Role* of and COX2 in silica induced [IL-6] release and loss of pneumocytes in co-cultures . Positive_regulation IL6 IL1B 19592492 2130633 Unexpectedly , we observed a paradoxical 10-fold increase in *induced* [IL-6] production in MEF cells from mice deficient in the IL-18R alpha-chain ( IL-18Ralpha ) compared with wild type MEF . Positive_regulation IL6 IL1B 19592492 2130635 Stable lines of IL-18Ralpha depleted human A549 cells were generated using shRNA , resulting in an increase of *induced* IL-1alpha , [IL-6] , and IL-8 compared to scrambled small hairpin RNA . Positive_regulation IL6 IL1B 19697035 2258167 The level of [IL-6] expression was strongly increased in both FLSs and THP-1 macrophages in *response* to and TNF-alpha , but the level by TNF-alpha was less than that by IL-1beta . Positive_regulation IL6 IL1B 19834007 2164907 released by stretch is at a low level unable to *induce* [IL-6] but sufficient to stimulate IGF-1 production . Positive_regulation IL6 IL1B 19912845 209730 During short-term incubations of U87MG cells ( 6 h ) in the presence of IL 1beta and dexamethasone ( DEX ) , DEX inhibited *stimulated* [IL 6] production over the entire range of the dose-response curve . Positive_regulation IL6 IL1B 19912845 209731 In fact , the ED ( 50 ) for *stimulated* [IL 6] production was about 1.3 pM in cells not preincubated with DEX , but was reduced to 0.25 pM in cells that were preincubated with DEX . Positive_regulation IL6 IL1B 20067446 2232540 Data provided prove that , in FLSs , constitutive as well as *induced* expression of [IL-6] is transiently and partially down-regulated by the short treatment of cells with low concentrations of NaHS . Positive_regulation IL6 IL1B 20107610 2178642 The *induced* [IL-6] levels were dose dependent with highest responses seen in HCAEC . Positive_regulation IL6 IL1B 2012180 156670 and tumor necrosis factor-alpha *induce* gene expression and production of leukocyte chemotactic factors , colony stimulating factors , and [interleukin-6] in human mesangial cells . Positive_regulation IL6 IL1B 2012180 156682 Similarly and TNF-alpha *induced* the [interleukin-6 (IL-6)] gene and active secretion of its mature protein . Positive_regulation IL6 IL1B 20206126 2229800 Qualified specificity of oubain for hepatocellular APP synthesis inhibition is demonstrated by lack of effectivity on *induced* [IL-6] release from primary human coronary artery smooth muscle cells . Positive_regulation IL6 IL1B 2036955 159760 IL-1 alpha and ( 0.04-25 ng/ml ) significantly *increased* [IL-6] release 3- to 4-fold in a concentration related manner during 6-h incubations ; Positive_regulation IL6 IL1B 2036955 159763 IL-1 alpha and ( 10 ng/ml ) , vasoactive intestinal peptide ( VIP , 500 nM ) , prostaglandin E2 ( PGE2 , 1 microM ) , and LPS ( 1 ng/ml ) *stimulated* [IL-6] release to a similar degree . Positive_regulation IL6 IL1B 2036955 159770 In the presence of VIP and PGE2 , IL-1 alpha and *increased* [IL-6] release without any apparent further change in extracellular or intracellular cAMP . Positive_regulation IL6 IL1B 2036955 159773 however , the ability of IL-1 alpha , , PGE2 , or LPS to *stimulate* [IL-6] release was not altered . Positive_regulation IL6 IL1B 2036955 159775 In addition , IL-1 alpha and *stimulated* [IL-6] release in the presence of maximally stimulative concentrations of PMA . Positive_regulation IL6 IL1B 2036955 159777 The synthetic glucocorticoid dexamethasone ( 10 nM ) significantly inhibited [IL-6] release *induced* by IL-1 alpha , , or LPS . Positive_regulation IL6 IL1B 20403707 2282298 as well as IL-6+sIL-6R *induced* [IL-6] production . Positive_regulation IL6 IL1B 20419825 2246676 On day 1 after infection , the secretion of both TNF-alpha and [IL-6] decreased significantly in the bronchoalveolar lavage fluid prepared from RSV infected offspring exposed to DBDE perinatally , but *increased* . Positive_regulation IL6 IL1B 20423350 2247130 Pre-incubation with beta(2)-adrenoceptor agonists ( salbutamol , salmeterol , formoterol ) augmented the release and mRNA expression of [IL-6] and IL-8 *induced* by and IL-1beta plus histamine , whereas NF-kappaB dependent transcription was significantly repressed , and AP-1 dependent transcription was unaffected . Positive_regulation IL6 IL1B 20525168 2284199 We have therefore examined the role of miR-146a during the *stimulated* [IL-6] and IL-8 release and proliferation in primary human airway smooth muscle ( HASM ) cells . Positive_regulation IL6 IL1B 20525168 2284203 Functional studies indicated that induced miR-146a expression does not negatively *regulate* [IL-6] and IL-8 release or basal proliferation . Positive_regulation IL6 IL1B 20525168 2284210 However , inhibition of *induced* [IL-6] and IL-8 release was observed at the super-maximal intracellular miR-146a levels obtained by transfection with miR-146a mimics and indicates that studies using miRNA mimics can produce false positive results . Positive_regulation IL6 IL1B 20538267 2284712 This study was conducted to evaluate the efficacy of hesperetin in regulating *induced* production of the matrix metalloproteinase (MMP)-3 and [IL-6] in human synovial cell line , SW982 . Positive_regulation IL6 IL1B 20538267 2284714 Treatment with hesperetin at 1 or 10 microM significantly ( P < 0.05 ) inhibited *induced* MMP-3 and [IL-6] production when measured by enzyme linked immunosorbent assay ( ELISA ) . Positive_regulation IL6 IL1B 20600535 2316082 This study was conducted to evaluate the efficacy of luteolin in regulating *induced* production of MMPs ( MMP-1 and -3 ) and cytokines ( tumor necrosis factor (TNF)-alpha and [IL-6] ) in human synovial cell line , SW982 . Positive_regulation IL6 IL1B 20610647 2296855 KdPT potently suppressed *induced* [IL-6] and IL-8 expression . Positive_regulation IL6 IL1B 20631892 2292048 IFNgamma and *cause* an increase of released [IL-6] protein level in a time dependent manner . Positive_regulation IL6 IL1B 2107652 128740 [Interleukin 6] possibly *induced* by in the pituitary gland stimulates the release of gonadotropins and prolactin . Positive_regulation IL6 IL1B 2121800 143907 IL-6 induction by LPS/Ca2+ ionophore is more sensitive to the suppressive effects of dexamethasone than is [IL-6] *induction* by . Positive_regulation IL6 IL1B 2203522 140654 while [IL-6] could be *induced* by both and tumor necrosis factor-alpha . Positive_regulation IL6 IL1B 2239094 144722 and tumour necrosis factor alpha *stimulate* the release of gonadotropin releasing hormone and [interleukin 6] by primary cultured rat hypothalamic cells . Positive_regulation IL6 IL1B 2239094 144724 The abilities of recombinant human and tumour necrosis factor alpha to *induce* release of GnRH and [interleukin 6] from primary culture of rat hypothalamic cells were examined . Positive_regulation IL6 IL1B 2239094 144727 These results suggest that and tumour necrosis factor alpha *stimulate* the secretions of GnRH and [interleukin 6] in the hypothalamus , and that these cytokines may be involved in the mechanism of GnRH secretion in the hypothalamus . Positive_regulation IL6 IL1B 2265243 147220 We investigated the effects of transforming growth factor beta ( TGF beta ) on the *induction* by of [IL-6] in human monocytes . Positive_regulation IL6 IL1B 2265243 147225 We found that *induced* [IL-6] messenger RNA expression in elutriated monocytes and IL-6 secretion in the supernatant . Positive_regulation IL6 IL1B 2265245 147229 Heated *caused* an increase of neither [IL-6] nor CSF activities . Positive_regulation IL6 IL1B 2310829 130064 In addition , monocyte production of [IL-6] , *induced* by , was specifically neutralized by anti-IL-1 beta antibodies , demonstrating that IL-1 , rather than a contaminant in the IL-1 preparation , was responsible for IL-6 induction . Positive_regulation IL6 IL1B 2335234 132668 Here we show that human *induces* [IL-6] synthesis and secretion in differentiated human chondrocytes . Positive_regulation IL6 IL1B 2335234 132669 The *induction* of [IL-6] synthesis by was also shown at the mRNA level . Positive_regulation IL6 IL1B 2346722 134851 This study investigates the capacity of interleukin-1 alpha (IL-1 alpha) , and tumour necrosis factor-alpha (TNF-alpha) to *induce* [interleukin-6 (IL-6)] production in freshly isolated myeloma cells ( MC ) and bone marrow derived stromal cells (MSC) . Positive_regulation IL6 IL1B 2346722 134853 Recombinant human ( rh ) IL-1 alpha , and TNF-alpha *augmented* production of [IL-6] in human MC . IL-6 was determined on a factor dependent Cess cell line . Positive_regulation IL6 IL1B 23636809 2800392 We found that the loss of FOXO3 in myometrial cells was associated with a significant decrease in *induced* [IL6] and IL8 expression and production , cyclooxygenase ( [ COX]-2 , official symbol PTGS2 ) expression and subsequent prostaglandin ( PGE2 and PGF2alpha ) release , and matrix metalloproteinase 9 (MMP9) and mRNA expression and activity . Positive_regulation IL6 IL1B 24279177 2876957 On days 12 to 13 of pregnancy myometrial release of E1 was markedly increased in *response* to and [IL6] . Positive_regulation IL6 IL1B 2786697 114805 Connective tissue type cells ( synoviocytes ) cultured from RA synovial tissue produce [IL-6] in *response* to , and IL-6 formation is increased by TGF-beta . Positive_regulation IL6 IL1B 2805453 121248 The ability of Escherichia coli derived lipopolysaccharide (LPS) , recombinant ( r ) ( rIL-1 beta ) , and r murine tumor necrosis factor-alpha ( rMuTNF-alpha ) to *induce* [interleukin 6 (IL-6)] production in vivo was investigated . Positive_regulation IL6 IL1B 2805453 121251 These data demonstrate the abilities of and TNF-alpha to *induce* [IL-6] production in vivo and indicate that LPS induction of IL-6 may be mediated , at least partially , through TNF-alpha action . Positive_regulation IL6 IL1B 7502703 327014 Inhibition of IL-1 beta with 1 muM interleukin-1 receptor antagonist ( IL-1ra ) abrogated the potentiating effects of T3 on *stimulated* [IL-6] production and blocked the combined effect of T3 and IL-1 beta on 45Ca release . Positive_regulation IL6 IL1B 7506738 244452 Signal transduction pathways *mediating* astrocyte [IL-6] induction by and tumor necrosis factor-alpha . Positive_regulation IL6 IL1B 7506738 244456 We have focused on signal transduction related to the *stimulation* of [IL-6] gene expression by and TNF-alpha . Positive_regulation IL6 IL1B 7506738 244458 Our results indicate that stimuli related to protein kinase C ( PKC ) , such as PMA and calcium ionophore A23187 , increase IL-6 expression , whereas pharmacologic inhibitors of PKC inhibit [IL-6] *induction* by and TNF-alpha . Positive_regulation IL6 IL1B 7506738 244460 However , inhibition of the cAMP pathway effector , protein kinase A , did not reduce the induction of astrocyte [IL-6] gene expression in *response* to or TNF-alpha , and an ELISA for cAMP detected only very small increases in cAMP synthesis in response to these cytokines . Positive_regulation IL6 IL1B 7506738 244464 These data suggest that although cAMP does activate astrocyte IL-6 gene expression , it is the PKC pathway that plays a primary role in the *stimulation* of astrocyte [IL-6] gene expression by and TNF-alpha . Positive_regulation IL6 IL1B 7519668 266178 Histamine ( 1-100 microM ) , substance P ( SP; 1-100 nM ) , and human ( IL-1 beta ; 1-30 pM ) *stimulated* the release of [IL-6] in a time- and concentration dependent manner , with EC50 values of 4.5 microM , 8 nM , and 4.5 pM , respectively . Positive_regulation IL6 IL1B 7529912 284281 We also found that , although did not activate phosphatidy-linositol turnover , it *induced* , a robust release of [IL-6] . Positive_regulation IL6 IL1B 7529912 284282 Other possible signal transduction mechanisms involved in *induced* [IL-6] release are discussed . Positive_regulation IL6 IL1B 7578850 290864 However , the nitrite production was unrelated to the *induced* inhibition of thyroglobulin (Tg) and cyclic AMP ( cAMP ) and the IL-1 beta induced [IL-6] production . Positive_regulation IL6 IL1B 7590883 336355 Although the IEC-6 cells are known to produce TGF-beta , autocrine secreted TGF-beta was found to have no effect on the elevated [IL-6] secretion *induced* by both TNF-alpha plus . Positive_regulation IL6 IL1B 7595543 334848 We have investigated the roles of tyrosine kinase and protein kinase C activity in *induced* [interleukin-6] production , using the U373 human astrocytoma cell line as a model system for astrocytes . Positive_regulation IL6 IL1B 7595543 334849 Complete to nearly complete inhibition of *induced* [interleukin-6] production was observed with the flavonoids genistein and quercetin , the bisindole alkaloids staurosporine and K-252a , or the tyrphostin AG879 . Positive_regulation IL6 IL1B 7629516 316734 Compared with *induced* [IL-6] production , cells treated with ceramide or exogenous sphingomyelinase induced 82 and 50 % of maximal IL-1 beta induced IL-6 levels by 6 h , respectively ; Positive_regulation IL6 IL1B 7671321 322631 *induced* [IL-6] production was maintained by CGRP after removal of IL1 beta . Positive_regulation IL6 IL1B 7686496 222171 [IL-6] production by HEC was significantly increased only in the *presence* of , TNF alpha , or MECIF activity . Positive_regulation IL6 IL1B 7743669 306081 However , *up-regulated* [IL-6] synthesis by 6-7-fold . Positive_regulation IL6 IL1B 7751003 306734 We investigated the effect of transforming growth factor-beta ( TGF-beta ) on *induction* of [IL-6] and IL-8 mRNA levels and protein production by human RPE cells . Positive_regulation IL6 IL1B 7751003 306742 Both TGF-beta and alone *induce* IL-6 mRNA and [IL-6] production in human RPE cells and synergize to enhance IL-6 mRNA levels and IL-6 production over a range of TGF-beta ( 0.1-10 ng/ml ) and IL-1 beta concentrations ( 5-500 U/ml ) . Positive_regulation IL6 IL1B 7768376 308389 *induces* the expression of [interleukin 6] in rat intestinal smooth muscle cells . Positive_regulation IL6 IL1B 7780037 309436 This induction was not due to a passive release of pre synthesized IL-6 , since IL-4 increased the level of [IL-6] mRNA expression *induced* by . Positive_regulation IL6 IL1B 7814800 285250 Furthermore , lipopolysaccharide , tumor necrosis factor-alpha , interferon-gamma , and phorbol ester *induced* [interleukin-6] production and , at the same time , suppressed the level of interleukin-6 receptor mRNA . Positive_regulation IL6 IL1B 7840168 293835 ZG cells released [IL-6] and TNF , and this release was *stimulated* by lipopolysaccharide , interleukin-1 alpha , , a protein kinase C activator , and a calcium ionophore without affecting intracellular adenosine 3 ' , 5'-cyclic monophosphate ( cAMP ) content . Positive_regulation IL6 IL1B 7910101 254235 Co-addition of the specific IL-1 receptor antagonist (IL-1ra) completely inhibited *induced* [IL-6] secretion but did not affect LPS stimulated IL-6 production during a 6 h incubation period . Positive_regulation IL6 IL1B 8008165 258481 has been shown to be synthesized in small amounts by astrocytes and can *induce* the expression of [interleukin-6] . Positive_regulation IL6 IL1B 8033802 264125 The endotoxin lipopolysaccharide ( LPS ; 100 ng/ml ) and ( 100 ng/ml ) *stimulated* [IL-6] release at 25 and 50 x 10 ( 3 ) cells/well . Positive_regulation IL6 IL1B 8040328 266673 [IL-6] gene expression and IL-6 secretion by A549 cells was *induced* by , TNF alpha , and by human alveolar macrophages and THP1 cells CM. Induction was abolished when CM were preincubated with anti-IL-1 beta and anti-TNF alpha antibody . Positive_regulation IL6 IL1B 8047839 267081 [IL-6] was detected in the culture supernatants of human GEC and its production was *enhanced* in time and dose dependent manner by lipopolysaccharide (LPS) , and tumour necrosis alpha ( TNF-alpha ) . Positive_regulation IL6 IL1B 8057147 268046 [Interleukin-6] secretion was remarkably *stimulated* by tumor necrosis factor-alpha , , and IL-4 , and was also influenced by a combination of epidermal growth factor and bromocriptine . Positive_regulation IL6 IL1B 8061104 268519 Cell populations from various sites including peripheral blood , bone marrow , lymph nodes , and osteolytic bone lesions were cultured and tested for spontaneous or alpha *induced* [IL-6] production in a sensitive bioassay . Positive_regulation IL6 IL1B 8100098 220149 C8 cell line , which formed abundant osteoid or bone and was accompanied by no osteoclasts in the xenografted tumors , produced no detectable levels of IL-6 without stimulation , and the production of [IL-6] in *response* to was slower . Positive_regulation IL6 IL1B 8205350 261164 *had* a stimulatory effect on [IL-6] production by HAT . Positive_regulation IL6 IL1B 8267048 239331 Primary cultures of amnion , chorion , and decidual cells were incubated in the *presence* and absence of , tumor necrosis factor-alpha , and [interleukin-6] . Positive_regulation IL6 IL1B 8275959 247189 *stimulates* [interleukin-6] production in placental villous core mesenchymal cells . Positive_regulation IL6 IL1B 8275959 247190 Because IL-1 beta is known to induce IL-6 production in nonplacental mesenchymal cells and is locally produced by maternal decidua , this study was designed to determine whether could *regulate* [IL-6] production by second trimester placental villous core mesenchymal cells ( VCMC ) in vitro . Positive_regulation IL6 IL1B 8275959 247192 In dose-response experiments , a specific dose-response *induction* of [IL-6] mRNA expression and IL-6-immunoreactive protein production by was demonstrated ; Positive_regulation IL6 IL1B 8275959 247193 In summary , *stimulates* VCMC [IL-6] production in a specific dose- and time dependent manner . Positive_regulation IL6 IL1B 8283061 247453 Both and the synthetic dsRNA , poly ( I:C ) , induced high levels of IL-6 mRNA and protein expression , whereas LPS and TNF-alpha *led* to only modest increases in [IL-6] protein and mRNA . Positive_regulation IL6 IL1B 8335922 223882 RT-PCR analysis of IL-1 beta treated cells showed an enhanced level of IL-6 mRNA at 4 h , suggesting that *enhanced* [IL-6] gene expression . Positive_regulation IL6 IL1B 8411809 233540 In this report , we demonstrated that [Interleukin-6 (IL-6)] production could be *induced* by stimulating renal cell carcinoma cell lines , namely ACHN , Caki-1 and TC-1 cells with . Positive_regulation IL6 IL1B 8413826 233941 [IL-6] secretion was *induced* by in a concentration as low as 1 x 10 ( -10 ) M ( p = 0.0008 ) ; Positive_regulation IL6 IL1B 8559475 337260 Secretion of [IL-6] by GECs was *increased* by transforming growth factor beta but not by . Positive_regulation IL6 IL1B 8576941 340903 Vesnarinone [ OPC-8212 ; 3,4-dihydro-6- ( 4- ( 3,4-dimethoxybenzoil ) -1-piperazinyl ) -2 ( 1H ) - quinolinone ] at 26 mumol/l significantly suppressed the production of [IL-6] , granulocyte macrophage colony stimulating factor ( GM-CSF ) and granulocyte colony stimulating factor ( G-CSF ) *induced* by . Positive_regulation IL6 IL1B 8580370 337506 Similarly , *induced* [IL-6] levels were 102-fold higher in HPMC ( median 288,800 pg/1 x 10 ( 5 ) cells ; range 93,125-552,800 ) than in OVCA . Positive_regulation IL6 IL1B 8598489 350732 does not cause neutrophil degranulation but does *lead* to [IL-6] , IL-8 , and nitrite/nitrate release when used in patients with cancer . Positive_regulation IL6 IL1B 8604711 352371 In addition , *induced* [interleukin-6] production by human mesothelial cells was measured in the presence of concentrations of calcium increasing from 0 to 3.0 mmol/L. Fc receptor- mediated uptake of S epidermidis by PMO in the complete absence of Ca++ was comparable to that by PMO incubated in GHBSS with calcium . Positive_regulation IL6 IL1B 8609408 352814 Moreover , in agonist activated macrophages , supernatants from Brucella cultures promoted an inhibition of the induction of both TNF-alpha expression and release , without affecting or [IL-6] *induction* . Positive_regulation IL6 IL1B 8627304 355868 Whereas activation of protein kinase A was able to induce expression of the IL-6 gene , it did not induce TNF alpha gene expression and was not involved in *induced* [IL-6] and TNF alpha gene expression . Positive_regulation IL6 IL1B 8638287 342969 IL-2 , [IL-6] , IL-8 , TNF-alpha , TNF-beta and IFN-gamma , but not IL-1 alpha , were *detected* in the monkey using human reagents . Positive_regulation IL6 IL1B 8706333 376299 However , IL-4 did not induce IL-6 secretion by the IEC-6 cells , nor did it alter *induced* [IL-6] secretion . Positive_regulation IL6 IL1B 8772585 379564 Stimulation of the various cultures with dramatically *augmented* stromal cell production of [IL-6] . Positive_regulation IL6 IL1B 8774705 379639 The levels of both secreted [IL-6] and IL-6 mRNA are significantly higher in *response* to in spite of the fact that stimulation by TNF-alpha alone enhances the half life of IL-6 mRNA . Positive_regulation IL6 IL1B 8780161 380051 After 24 hours , contact allergens not only increased the expression of but also *induced* the expression of IL-1 alpha , TNF-alpha , GM-CSF , and [IL-6] proteins mainly by suprabasal keratinocytes . Positive_regulation IL6 IL1B 8785390 371455 Similarly , *induced* [IL-6] synthesis by HPMC was also only significantly reduced by the pH 5.2 lactate solution . Positive_regulation IL6 IL1B 8817528 384601 Moreover , morphine potentiated the [IL-6] response *induced* by ( 400 ng , i.p. or i.c.v. ) . Positive_regulation IL6 IL1B 8817534 384602 In the present study , the effects of seven non-steroidal anti-inflammatory drugs ( NSAIDs ) on *induced* [IL-6] mRNA expression and protein synthesis in a human astrocytoma cell line were investigated . Positive_regulation IL6 IL1B 8817534 384603 Tenidap , naproxen and meloxicam inhibited the *induced* synthesis of [IL-6] , whereas ibuprofen , piroxicam , diclofenac and indomethacin had no effect . Positive_regulation IL6 IL1B 8828503 385434 We have previously reported that *enhances* [IL-6] release and phospholipase A2 (PLA2) mediated hydrolysis of phosphatidylcholine ( PC ) in AP cells . Positive_regulation IL6 IL1B 8828503 385436 In addition , H7 ( 20 microM ) abolished the *stimulation* of [IL-6] release by ( 0.16-100 ng/mL ) . Positive_regulation IL6 IL1B 8893677 392334 *stimulated* endometrial [IL-6] protein production in time- and dose dependent manners . Positive_regulation IL6 IL1B 8895322 392457 Finally , and tumor necrosis factor-alpha ( 1-1000 pM ) *stimulated* dose dependent increases in the secretion of [interleukin-6] and monocyte chemoattractant protein-1 at 34 C and 40C . Positive_regulation IL6 IL1B 8959581 401936 The samples are incubated with or without and the subsequent ex vivo *induction* of [IL-6] determined . Positive_regulation IL6 IL1B 8980876 403751 If added to cells activated by interferon gamma and lipopolysaccharide , radicicol analogue A not only inhibited the secretion of but also *induced* an extremely rapid degradation of IL-1 beta , [IL-6] and TNF-alpha mRNA to undetectable levels within 5-8 h . Positive_regulation IL6 IL1B 9003059 410606 Furthermore , PGE2 potentiated *induced* [IL-6] mRNA synthesis . Positive_regulation IL6 IL1B 9115637 423514 This increase in CDS activity also leads to increased secretion of tumor necrosis factor-alpha and [interleukin-6] from endothelial ECV304 cells upon *stimulation* with , suggesting that CDS overexpression may amplify cellular signaling responses from cytokines . Positive_regulation IL6 IL1B 9160463 431714 Normal , control disc specimens significantly increased their production of matrix metalloproteinases , nitric oxide , [interleukin-6] , and prostaglandin E2 in *response* to . Positive_regulation IL6 IL1B 9160463 431716 Herniated lumbar and cervical discs , which were spontaneously releasing increased levels of these biochemical agents , further increased their production of nitric oxide , [interleukin-6] , and prostaglandin E2 in *response* to . Positive_regulation IL6 IL1B 9162522 389374 [IL-6] expression in transformed swine testicular (TST) fibroblasts was *enhanced* by TNF and and to a lesser extent by poly ( I ) . Positive_regulation IL6 IL1B 9202660 440054 PDTC , TLCK , and genistein each inhibited *induced* [IL-6] production by the Caco-2 cells in a dose dependent fashion . Positive_regulation IL6 IL1B 9202660 440055 The results suggest that *induced* [IL-6] production in the enterocyte is associated with activation of NF-kappa B . Positive_regulation IL6 IL1B 9256609 448385 A cytokine [IL-6] induced the CRP production in the *presence* of , but did not affect the constitutive production of SAA . Positive_regulation IL6 IL1B 9277562 450796 The role of the central noradrenergic system in systemic [interleukin-6 (IL-6)] production *induced* by intravenously administered recombinant human was examined in rats . Positive_regulation IL6 IL1B 9277562 450797 A modest inhibition of the *induced* plasma [IL-6] production was observed following pretreatment with prazosin ( 20 micrograms/rat i.c.v. ) but not after administration of idazoxan or propranolol . Positive_regulation IL6 IL1B 9277562 450798 Adrenalectomy produced an augmented plasma IL-6 response to intravenous IL-1 beta , whereas chemical sympathectomy with intraperitoneal injection of 6-OHDA ( 50 or 100 mg/kg ) decreased the *induced* plasma [IL-6] levels . Positive_regulation IL6 IL1B 9309381 454744 [IL6] release and resorption ( 45Ca release ) were *induced* by in neonatal mouse calvaria bones in culture . Positive_regulation IL6 IL1B 9316474 456177 In addition , IL-1 beta , [IL-6] , and TNF-alpha mRNAs were rapidly ( 7 h ) upregulated in the pancreas , and intrapancreatic and IL-6 protein levels rapidly *increased* ( 3-fold and 6.4-fold , respectively ) during acute pancreatitis . Positive_regulation IL6 IL1B 9321873 456326 Moreover the three antagonists affect [IL-6] *induction* by central and peripheral with a similar pattern , indicating that the brain endogenous opioid system plays a general role in the regulation of this cytokine . Positive_regulation IL6 IL1B 9326296 457100 These results demonstrate that expression of the genes encoding [IL-6] , IL-6R , and gp130 can be up-regulated in selective regions of the brain in *response* to the bacterial endotoxin LPS and the proinflammatory cytokine ( only for IL-6R expression ) . Positive_regulation IL6 IL1B 9329125 457449 and interferon-gamma *regulate* [interleukin-6] production in cultured human intestinal epithelial cells . Positive_regulation IL6 IL1B 9329125 457455 The results suggest that enterocyte [IL-6] production is *stimulated* by and that this effect is potentiated by IFN-gamma . Positive_regulation IL6 IL1B 9365094 463084 However , the secretion of [IL-6] , IL-8 , and GM-CSF stimulated by the complexes was not completely *dependent* upon the secretion of . Positive_regulation IL6 IL1B 9387960 466484 Furthermore , pre-exposure of cells to persisting and nonpersisting isolates did not block subsequent *induced* [IL-6] production . Positive_regulation IL6 IL1B 9393919 468016 Both and TNFalpha *stimulated* [IL-6] and PGE2 release from the osteoblast-like cells . Positive_regulation IL6 IL1B 9449430 475371 NSAIDS inhibit the *induced* [IL-6] release from human post-mortem astrocytes : the involvement of prostaglandin E2 . Positive_regulation IL6 IL1B 9449430 475372 The glucocorticoid dexamethasone inhibited the *activated* release of [IL-6] from the postmortem astrocyte cultures A157 and A295 and from the astroglioma cell lines . Positive_regulation IL6 IL1B 9449430 475374 Addition of exogenous PGE2 prevented the inhibitory effect of indomethacin and BF389 on the *activated* [IL-6] release from A157 astrocytes and largely potentiated the IL-1 induced release of IL-6 from all astrocytes/astroglioma cells tested . Positive_regulation IL6 IL1B 9449430 475375 Dexamethasone also inhibited the PGE2 release from the astrocytes and astroglioma cells , however the inhibitory effect of dexamethasone on the *activated* [IL-6] release could not be prevented by the addition of PGE2 . Positive_regulation IL6 IL1B 9516466 493094 Transcriptional roles of CCAAT/enhancer binding protein-beta , nuclear factor-kappaB , and C-promoter binding factor 1 in *induced* [IL-6] synthesis by human rheumatoid fibroblast-like synoviocytes . Positive_regulation IL6 IL1B 9516466 493152 Site-specific mutagenesis analysis demonstrated that the NF-kappaB and CBF1 binding elements regulated inducible activity of the [IL-6] promoter in *response* to stimulation , whereas the C/EBPbeta binding element mainly regulated basal activity . Positive_regulation IL6 IL1B 9523575 493929 Whereas the antioxidant pyrrolidinedithiocarbamate was only able to inhibit *induced* [IL-6] expression , inhibition of protein kinase C prevented IL-6 expression induced by all three substances . Positive_regulation IL6 IL1B 9523575 493930 Promoter deletion analysis revealed that *induced* [IL-6] expression required the transcription factor nuclear factor-kappaB (NF-kappaB) , whereas SP- and histamine induced IL-6 synthesis was essentially controlled by NF-IL-6 . Positive_regulation IL6 IL1B 9557955 499971 The biological activities of IL-1 receptor antagonist (IL-1ra) or IL-1ra-like molecule were measured by its ability to suppress the *mediated* induction of adhesion molecules ( ICAM and ELAM ) on EC and of [IL-6] secretion by these cells . Positive_regulation IL6 IL1B 9572400 501804 On the other hand , there was no change in serum levels of and IL-8 , and the serum levels of IL-1ra and [IL-6] even *increased* at the end of a single PE , in spite of high levels of all cytokines and adhesion molecules in the plasma filtrate . Positive_regulation IL6 IL1B 9610742 508847 ( 18 and 180 pM ) *stimulated* bone resorption and increased [IL-6] . Positive_regulation IL6 IL1B 9610742 508848 Since bone cultures contain multiple cell types , further experiments were carried out to determine whether alendronate could increase *stimulated* [IL-6] production in an osteoblast cell line , UMR-106 . Positive_regulation IL6 IL1B 9626137 511766 Exogenous *stimulated* secretion of [IL-6] and IL-11 in a saturable , dose dependent manner . Positive_regulation IL6 IL1B 9632526 512704 It is concluded that induced ACTH , cort and [IL-6] production is *mediated* by interleukin 1 type I receptors . Positive_regulation IL6 IL1B 9637162 513632 TNF-alpha , IL-1alpha , and *increased* [IL-6] production in normal skin ( p < 0.05 ) . Positive_regulation IL6 IL1B 9659156 517168 Stimulation of HIMEC and HUVEC with recombinant human ( rh ) or rhTNF-alpha *induced* cell associated bioactive IL-1 alpha but not IL-1 beta , as well as enhanced secretion of both [IL-6] and IL-8 . Positive_regulation IL6 IL1B 9695734 524376 Endotoxemia and *stimulate* mucosal [IL-6] production in different parts of the gastrointestinal tract . Positive_regulation IL6 IL1B 9695734 524379 Treatment of mice with TNF alpha reduced IL-6 levels in gastric mucosa whereas *increased* [IL-6] levels in mucosa of small intestine . Positive_regulation IL6 IL1B 9698530 524942 In recent studies , *stimulated* the production of [IL-6] in human enterocytes . Positive_regulation IL6 IL1B 9698530 524943 We tested the hypothesis that heat shock regulates *induced* [IL-6] production in human intestinal epithelial cells . Positive_regulation IL6 IL1B 9698530 524944 Heat shock resulted in the production of HSP-70 and potentiated *induced* [IL-6] production . Positive_regulation IL6 IL1B 9698530 524945 The results suggest that *induced* [IL-6] production in human enterocytes is increased in association with the heat shock response . Positive_regulation IL6 IL1B 9712363 527253 Estrogen inhibits *induced* [interleukin-6] production by human osteoblast-like cells . Positive_regulation IL6 IL1B 9712363 527254 Using enzyme linked immunosorbent assay ( ELISA ) , we demonstrate that significantly *enhances* [IL-6] secretion into culture supernatants in a dose dependent and time dependent manner . Positive_regulation IL6 IL1B 9733787 531041 Regulation of *induced* [interleukin-6] gene expression in human fibroblast-like synoviocytes by p38 mitogen activated protein kinase . Positive_regulation IL6 IL1B 9733787 531068 Here , we provide evidence that p38 MAP kinase is activated in *response* to in human FLSs and is involved in [IL-6] synthesis by stabilizing IL-6 mRNA . Positive_regulation IL6 IL1B 9769153 538705 We have determined that the human colonic carcinoma cell line Caco-2 is capable of secreting IL-6 when stimulated by the inflammatory cytokines IL-1beta or tumor necrosis factor-alpha (TNF-alpha) , and stimulation of these cells with plus TNF-alpha *induced* a synergistic enhancement of [IL-6] secretion . Positive_regulation IL6 IL1B 9792466 542542 We observed that ( 1 ) and TNFalpha *induced* [IL-6] in a dose and time dependent fashion , ( 2 ) TGFbeta 1 and 2 enhanced basal and IL-1beta and TNFalpha induced IL-6 expression , ( 3 ) ET-1 elicited a dose dependent stimulatory effect on IL-6 expression . Positive_regulation IL6 IL1B 9818659 546923 *increased* the production of [IL-6] and GMCSF by mock infected and infected cells . Positive_regulation IL6 IL1B 9832618 551977 Regulation of *induced* [interleukin-6] gene expression in human fibroblast-like synoviocytes by glucocorticoids . Positive_regulation IL6 IL1B 9832620 551979 *enhanced* the production of [IL-6] and stromelysin-1 , and the surface expression of ICAM-1 , in a manner similar to that in the parental FLSs . Positive_regulation IL6 IL1B 9832620 551981 SB203580 , a specific inhibitor of p38 MAP kinase , significantly inhibited *induced* [IL-6] and stromelysin-1 production by both parental FLSs and MH7A cells ; Positive_regulation IL6 IL1B 9850935 554328 Furthermore , PGE2 potentiated *induced* [IL-6] mRNA synthesis . Positive_regulation IL6 IL1B 9853285 554906 *stimulated* [IL-6] release from HPMC and HPFB was used as the cell functional parameter . Positive_regulation IL6 IL1B 9853285 554907 While short ( 30 min ) pre-exposure to lactate buffered PDF significantly reduced the *stimulated* [IL-6] release from HPMC during a subsequent recovery period ( 24 hr ) , a significant decrease in HPMC IL-6 secretion with bicarbonate buffered PDF was only observed after prolonged ( > or = 60 min ) exposure . Positive_regulation IL6 IL1B 9886419 584720 Since C3a has been shown to induce PGE2 production by monocytes , and PGE2 has been shown to influence cytokine production , we investigated the potential role of PGE2 in C3a mediated enhancement of LPS- and *induced* [IL-6] production . Positive_regulation IL6 IL1B 9888463 585168 Second , application of SP or neurokinin A ( NKA ) to NK1R+ glioma cell lines increased the secretion of interleukin 6 (IL-6) and potentiated [IL-6] secretion *induced* by . Positive_regulation IL6 IL1B 9922315 588227 These agents each increased cyclic adenosine monophosphate activity in muscle substance P , and the neurokinin 1 agonist Ac- [ Arg6,Sar9,Met ( O2 ) 11 ] substance P ( 6-11 ) inhibited the *induced* [IL-6] release . Positive_regulation IL6 IL1B 9922315 588228 This study shows neuropeptide and sympathetic modulation of *induced* [IL-6] production by intestinal smooth muscle . Positive_regulation IL6 IL1B 9927320 588535 and catecholamines synergistically *stimulate* [interleukin-6] release from rat C6 glioma cells in vitro : a potential role for lysophosphatidylcholine . Positive_regulation IL6 IL1B 9927320 588536 Forty ng/ml *induced* a maximal 30-fold stimulation of [IL-6] release ( P < 0.01 ) ; Positive_regulation IL6 IL1B 9927320 588537 We have demonstrated that *stimulates* [IL-6] release from rat C6 glioma cells via a noncAMP mediated mechanism that may involve LPC . Positive_regulation IL6 IL1R2 8387521 218042 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL6 IL6R 10633884 576675 *Role* of soluble in inflamed gingiva for binding of [interleukin-6] to gingival fibroblasts . Positive_regulation IL6 IL6R 11502067 847428 The association of gp130 with IL-6 and *leads* to the formation of the high-affinity [IL-6] receptor complex , to the linkage of two gp130 subunits and to signal transduction . Positive_regulation IL6 IL6R 11902263 921973 In endotoxin treated rats , there was significant inhibition of [interleukin-6] *activation* of janus kinase-1 , gp 130 , the , STAT1 , and STAT3 . Positive_regulation IL6 IL6R 1321736 192044 We studied the *role* of in binding , internalization and down-regulation of the hepatic [IL6-receptor (IL6R)] by its ligand in human hepatoma cells ( HepG2 ) . Positive_regulation IL6 IL6R 16645023 1553164 Soluble ( sIL-6Ralpha ) *enhances* , while sgp130 inhibits [IL-6] signalling . Positive_regulation IL6 IL6R 23372742 2739188 These elevated levels may *contribute* to increased [interleukin-6] activity through the trans signaling pathway . Positive_regulation IL6 IL6R 8477802 218579 Serum soluble in MRL/lpr mice is elevated with age and *mediates* the [interleukin-6] signal . Positive_regulation IL6 IL6R 8878515 390665 In this study the ability of soluble ( sIL-6R ) to *stimulate* [interleukin-6 (IL-6)] synthesis in human fibroblasts is described . Positive_regulation IL6 IL6R 9641793 511039 also *increased* [IL-6] levels measured in medium probably due to a decrease in the metabolization induced by the blockage of the receptors and the consequent accumulation of IL-6 in the media . Positive_regulation IL6 JAG1 20870935 2337222 Jagged1 induction was augmented by IFN-? , was partially dependent on canonical TLR activated NF-?B and MAPK signaling pathways , and elevated expression *augmented* TLR induced [IL-6] production . Positive_regulation IL6 KRT38 17213200 1702696 [Interleukin-6] *induces* expression in intestinal epithelial cells : potential role of keratin-8 in interleukin-6 induced barrier function alterations . Positive_regulation IL6 LBP 16249503 1471752 In a dose-dependant manner , tear CD14 and *mediated* the secretion of [interleukin (IL)-6] and IL-8 by corneal epithelia cells when challenged with LPS . Positive_regulation IL6 MAP2K6 15867183 1404213 In cultured cardiac myocytes , specific activation of stress activated mitogen activated protein kinase , p38 , by upstream activator *led* to significant induction of tumor necrosis factor-alpha and [interleukin-6] secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation IL6 MAP2K6 16432158 1516244 We conclude that SOCS-1 methylation status can differentially affect STAT3 *activation* by [IL-6R] and EGFR through JAK or in different HNSCC and response to pharmacologic antagonists . Positive_regulation IL6 MAP2K6 17130674 1661384 PD98059 , a ( mitogen activated protein kinase kinase ) inhibitor , and BAPTA-AM [ O , O'-bis ( 2-aminophenyl ) ethyleneglycol-N , N,N ' , N'-tetraacetic acid , tetraacetoxymethyl ester ] , an intracellular Ca ( 2+ ) chelator , *reduced* UTP induced ERK phosphorylation and [IL-6] mRNA expression . Positive_regulation IL6 MAP2K6 18500674 1965709 PD98059 , an inhibitor of , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase , *suppressed* FGF-2 stimulated [IL-6] synthesis . Positive_regulation IL6 MAP2K6 18771907 1962561 The PGD2 stimulated [IL-6] synthesis was *reduced* by PD98059 , a inhibitor , and SB203580 , an inhibitor of p38 mitogen activated protein (MAP) kinase , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation IL6 MAP2K6 19103208 2036309 Inhibitors of STAT1 , ( MEK ) ( PD98059 ) , and phosphatidyl inositol 3 kinase (PI3K) ( LY294002 ) , blocked gp120 induced STAT1 activation and significantly *diminished* IL-8- , [IL-6-] , and gp120 induced monocyte adhesion and migration across in vitro BBB models . Positive_regulation IL6 MAP2K6 21054880 2349390 signalling is *necessary* for synergistic induction of [IL-6] by palmitate and insulin . Positive_regulation IL6 MAP2K6 8557683 347554 While expression of CD45 was associated with a decrease in the responsiveness of early insulin receptor signaling , [interleukin 6-dependent] *activation* of and mitogen activated protein kinase was equivalent between CD45- and CD45+ cells . Positive_regulation IL6 MAP2K6 9625314 511674 The inhibitor PD 098059 abolished phosphorylation of the extracellular signal regulated kinases-1 and -2 in response to lipopolysaccharide , irrespective of the medium osmolarity , and *diminished* lipopolysaccharide induced interleukin-6 mRNA expression and [interleukin-6] production under normo- and hypoosmotic conditions by about 50 % ; Positive_regulation IL6 MATN2 19840795 2165253 stimulation *leads* to the induction of MMP1 , MMP3 , MMP13 , COX-2 , iNOS , IL-1beta , TNFalpha , [IL-6] and IL-8 . Positive_regulation IL6 MIP 23614243 2774775 The production of Th17 associated cytokines/chemokines such as [IL-6] , IL-17 , KCand *increased* , which peaked on day 7 post-infection , then gradually reduced . Positive_regulation IL6 MMP28 15996070 1430150 [IL-6/sIL-6R] markedly *induced* activation of STAT and extracellular signal related kinase ( ERK1/2 ) and the subsequent expression of the collagenases MMP-1 and MMP-13 as well as MMP-3 , an aggrecan degrading enzyme and activator of . Positive_regulation IL6 MMP7 15996070 1430166 [IL-6/sIL-6R] markedly *induced* activation of STAT and extracellular signal related kinase ( ERK1/2 ) and the subsequent expression of the collagenases MMP-1 and MMP-13 as well as MMP-3 , an aggrecan degrading enzyme and activator of . Positive_regulation IL6 PECAM1 18025177 1827645 In this study , we demonstrate that ligation with CD38-Fc fusion protein negatively *regulates* LPS induced proinflammatory cytokine TNF-alpha , [IL-6] , and IFN-beta production by inhibiting JNK , NF-kappaB , and IFN regulatory factor 3 activation in macrophages . Positive_regulation IL6 PGC 22117073 2535021 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL6 PTGER2 11071876 748652 Using neutrophils from EP2- and EP4-deficient mice in combination with EP2- and EP4-selective agonists , it was found that the augmentation of [IL-6] was *mediated* mainly by the EP2 receptor and the suppression of TNF-alpha by the EP4 receptor and partially by the receptor . Positive_regulation IL6 RGS16 14566449 1165129 IL-1beta ( 1.75-fold ) and TNFalpha ( 1.62-fold ) but not [IL-6] and IFNgamma *induced* protein expression . Positive_regulation IL6 RGS2 11996904 939170 Finally , we tested the effect of overexpression on PTH- and fluprostenol *induced* [interleukin (IL)-6] promoter activity in MOB cells . Positive_regulation IL6 S100B 10617115 656429 *induction* of the proinflammatory cytokine [interleukin-6] in neurons . Positive_regulation IL6 S100B 10617115 656430 We used RT-PCR and electrophoretic mobility shift assay to assess *induction* of [IL-6] expression and the role of kappaB dependent transcription in this induction in neuron enriched cultures and in neuron-glia mixed cultures from fetal rat cortex . Positive_regulation IL6 S100B 10617115 656431 ( 10 or 100 ng/ml x 24 h ) *increased* [IL-6] mRNA levels two- and fivefold , respectively ( p < 0.05 in each case ) , and S100beta ( 100-1,000 ng/ml ) induced increases in medium levels of biologically active IL-6 ( 30-80 % ) . Positive_regulation IL6 S100B 10617115 656432 *induction* of [IL-6] expression correlated with an increase in DNA binding activity specific for a KB element and was inhibited ( 75 % ) by suppression of kappaB binding with double stranded `` decoy '' oligonucleotides . Positive_regulation IL6 S100B 16551628 1555609 An inhibitor of Src kinase , PP2 , significantly blocked *induced* activation of Src kinase , mitogen activated protein kinases , transcription factors NF-kappaB and STAT3 , superoxide production , tyrosine phosphorylation of Cav-1 , VSMC migration , and expression of the pro-inflammatory genes monocyte chemotactic protein-1 and [interleukin-6] . Positive_regulation IL6 S100B 17604861 1786625 In the *presence* of hypothermia induced [IL-6] release in primary astrocytes was significantly increased but reduced in BV-2 microglial cells and primary neurons . Positive_regulation IL6 S100B 23755753 2797805 Soluble RAGE ( sRAGE ) reduced S100B dependent secretion of TNF-alpha but did not decrease *dependent* secretion of [IL-6] . Positive_regulation IL6 S1PR3 23766515 2823910 PAL treatment induced the proinflammatory cytokine [interleukin (IL)-6] in a manner dependent on SphK1 , and this was *attenuated* by inhibition of the ( S1PR3 ) . Positive_regulation IL6 SELL 22977256 2688595 These results show that GdA interacts with to *induce* [IL-6] production in monocytes/macrophages by activating the ERK signaling pathway . Positive_regulation IL6 SLC28A1 15464233 1305049 TNF-alpha and [IL-6] independently *induced* protein expression in cultured liver parenchymal and FAO hepatoma cells by PI-3 kinase- and ERK dependent mechanisms , respectively . Positive_regulation IL6 SPHK1 17686057 1781488 Although sphingosine kinase (SPHK) signalling is known to play important roles in the regulation of cell proliferation and apoptosis , the *role* of activation in [IL-6] signalling and in the pathology of MM remains unclear . Positive_regulation IL6 SPHK1 23933064 2845042 Furthermore , deficiency *attenuated* hyperoxia induced accumulation of [IL-6] in bronchoalveolar lavage fluids and NADPH oxidase (NOX) 2 and NOX4 protein expression in lung tissue . Positive_regulation IL6 STAT4 7638186 317686 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL6 STK39 10360689 619715 These data suggest that particle induced macrophage release of TNF-alpha and [IL-6] does not require phagocytosis but is *dependent* on tyrosine and activity culminating in activation of Positive_regulation IL6 STK39 8258686 238719 Our study demonstrated that IL-2 , IL-4 , and [IL-6-stimulation] of IgM secretion by SKW6.4 cells was *inhibited* by either the inhibitor , 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperizine dihydrochloride ( H7 ) or the tyrosine kinase inhibitor , genistein . Positive_regulation IL6 STK39 8258686 238749 Taken together , our data demonstrate that activation of both a and a tyrosine kinase is *involved* in the IL-2 , IL-4 , and [IL-6-stimulation] of IgM secretion by SKW6.4 cells and activation of the same or a similar serine/threonine protein kinase is an early step in the signal transduction pathway used by these cytokines . Positive_regulation IL6 TLR7 12045249 950126 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL6 TLR7 15588425 1345924 MEFs were highly responsive to TLR-ligand activation and secreted high levels of both [IL-6] and MCP-1 in *response* to ligands . Positive_regulation IL6 TLR7 15611271 1357370 Furthermore , different ligands *stimulated* [IL-6] and TNF-alpha production via signaling pathways , which showed unique characteristics . Positive_regulation IL6 TLR7 15994412 1446983 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for tumor necrosis factor ( TNF-alpha ) , [interleukin 6] , nitric oxide synthase-II ( iNOS ) , and NADPH oxidase 2 (Nox2) . Positive_regulation IL6 TLR7 16362041 1512387 We found that the serine phosphorylation was crucial for *induced* [interleukin 6] production and this process is regulated by TRAF6 , a key adaptor molecule for the TLR pathway . Positive_regulation IL6 TLR7 16368889 1539747 The induction of IFN-alpha and [IL-6] by U1snRNPs in murine bone marrow derived PDCs required the presence of intact U1RNA and was largely *dependent* on but independent of Tlr3 . Positive_regulation IL6 TLR7 16413922 1514428 IkappaBNS-deficient macrophages and dendritic cells show increased *mediated* expression of genes such as [IL-6] and IL-12p40 , which are induced late after TLR stimulation . Positive_regulation IL6 TLR7 17054926 1642074 Ligand activation of TLR2 , TLR4 and TLR5 , but not TLR3 , or TLR9 , *resulted* in cardiomyocyte expression of the inflammatory cytokine [IL-6] , the chemokines KC and MIP-2 , and the cell surface adhesion molecule ICAM-1 . Positive_regulation IL6 TLR7 17507094 1751007 In contrast , both TLR4- and *induced* [IL6] mRNA are significantly blocked by TRAF6 knockdown . Positive_regulation IL6 TLR7 17521321 1767162 natural killer (NK)1.1 ( - ) CD11c ( + ) liver DC subsets ( conventional DCs , T cell receptor ( TcR ) beta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( - ) and plasmacytoid DCs , TcRbeta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( + ) ) efficiently endocytose dextran and produce significant levels of tumour necrosis factor (TNF)-alpha , [interleukin (IL)-6] and IL-12 p40 in *response* to ligands , with responses higher than splenic DCs . Positive_regulation IL6 TLR7 17785797 1790728 In primary macrophages from mice with a targeted deletion of the atf3 gene ( ATF3-knockout ( KO ) ) , *stimulated* levels of IL-12 and [IL-6] were elevated relative to responses in wild-type macrophages . Positive_regulation IL6 TLR7 17918201 1819400 In this study , we investigated which mouse B cell subsets are the most potent cytokine producers , and examined the *role* of in the control of secretion of [IL-6] , IL-10 , IL-12 and IFN-gamma by B cells . Positive_regulation IL6 TLR7 18271077 1865822 Stimulation with TLR2 , TLR4 and ligands , as well as TLR3 ligand , *resulted* in significantly lower production of TNF-alpha , but neither [IL-6] nor IL-12p70 , by DCs from XLA patients in comparison to normal controls . Positive_regulation IL6 TLR7 18312842 1879480 Toxoplasma profilin is essential for host cell invasion and dependent *induction* of an [interleukin-12] response . Positive_regulation IL6 TLR7 19322177 2064486 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of [interleukin (IL)-6] and IL-12p40 ( also known as IL12b ) , but not TNF , in *response* to ligands . Positive_regulation IL6 TLR7 19430534 2077888 Moreover , *dependent* [IL6] and IL12P40 production induced by lipopolysaccharide (LPS) , R837 or CpG ODN 1826 was reduced in IRF-5 ( P68 ) expressing cells as compared to the control cells . Positive_regulation IL6 TLR7 19564352 2104272 In a phenotypic screen of the wild derived mouse strain MOLF/Ei , we describe an earlier and more potent mediated *induction* of [IL-6] transcription compared with the classical inbred strain C57BL/6J . Positive_regulation IL6 TLR7 19886804 2258369 This failure to catabolize trp is not due to defective TLR signaling as demonstrated by *induction* of [interleukin 6 (IL-6)] by activation . Positive_regulation IL6 TLR7 19890037 2165889 MAPKs are crucial for TNF-alpha and [IL-6] production by innate immune cells in *response* to ligands . Positive_regulation IL6 TLR7 19897783 2166036 In human gingival fibroblasts , cyclosporin alone did not induce evident inflammatory responses , but augmented the expression of CD54 and the production of [interleukin (IL)-6] and IL-8 *induced* by ligands , whereas phenytoin attenuated those responses . Positive_regulation IL6 TLR7 20337718 2273186 WNV infection or agonist treatment of gammadelta T cells *induced* the production of IFN-gamma , tumor necrosis factor-alpha and [IL-6] , which are known to promote DC maturation . Positive_regulation IL6 TLR7 20632067 2368017 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in *mediated* activation of caspase 1 and [interleukin-1ß] . Positive_regulation IL6 TLR7 20840632 2363799 ligation by small chemical molecules will still *induce* [interleukin-6 (IL-6)] and tumour necrosis factor-a secretion , but not interferon-a or IL-12 . Positive_regulation IL6 TLR7 20870935 2337217 Jagged1 induction was augmented by IFN-? , was partially dependent on canonical TLR activated NF-?B and MAPK signaling pathways , and elevated Jagged1 expression augmented *induced* [IL-6] production . Positive_regulation IL6 TLR7 20977341 2344177 Preterm neonates had globally attenuated *stimulated* [interleukin (IL)-6] , interferon-a , and , to a lesser extent , tumor necrosis factor-a responses but demonstrated relative preservation of anti-inflammatory IL-10 responses in monocytes and dendritic cell subtypes . Positive_regulation IL6 TLR7 21039603 2382364 PDCs matured under Th1-like conditions showed a higher expression of antigens involved in T-cell co-stimulation and antigen presentation like CD40 , CD80 , CD83 and HLA-DR as well as a higher secretion of [IL-6] and IFN-a in *response* to compared to Th2-pDCs . Positive_regulation IL6 TLR7 21223583 2493944 The ability of IFNa2 to regulate *induced* [interleukin (IL)-6] and CC chemokine ligand 2 production was also assessed . Positive_regulation IL6 TLR7 21689906 2505144 As a result , IVIg suppresses *induced* production of the proinflammatory [IL-6] , but not that of the anti-inflammatory IL-10 . Positive_regulation IL6 TLR7 21737940 2456114 The effects of two types of chondroitin sulphate ( CS ) , CS-A and CS-C , their oligosaccharides ( oligo-CSs ) , and disaccharides ( Di-CSs ) on *mediated* secretion of [interleukin (IL)-6] were compared using macrophage-like cell line J774.1 . Positive_regulation IL6 TLR7 21914077 2479393 We previously showed that chronic exposure to the core antigen induces hyporesponsiveness to TLR ligands in antigen presenting cells via activation of TLR2 and that stimulation with ligands *results* in impaired [IL-6] production by peripheral blood monocytes from HCV infected patients . Positive_regulation IL6 TLR7 22042224 2540128 Activation of *leads* to activation of NF-?B and release of proinflammatory cytokines , such as [IL-6] and TNF-a . Positive_regulation IL6 TLR7 22345668 2572059 Knockdown of hnRNP U expression greatly attenuated TLR induced expression of TNF-a , IL-6 , and IL-1ß , but not IL-12 , whereas hnRNP U overexpression greatly increased *induced* expression of TNF-a , [IL-6] , and IL-1ß . Positive_regulation IL6 TLR7 22440523 2600841 The expression of *induced* production of TNF-a , IFN-a , [IL-6] , and IL-12 were measured by multicolor flow cytometry . Positive_regulation IL6 TLR7 22521509 2613619 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL6 TLR7 22546503 2631904 In conclusion , the present study has demonstrated that progesterone suppresses TLRs triggered immune response by regulating miR-155 , and the decreased miR-155 contributes to inhibit *induced* [IL-6] and IFN-ß via increased SOCS1 expression . Positive_regulation IL6 TLR7 22550345 2613989 Neither the missense nor the null allele affected *induced* secretion of [IL-6] . Positive_regulation IL6 TLR7 22751696 2670321 To do so , we analyzed *induced* interleukin (IL)-1ß and [IL-6] responses in freshly isolated peripheral blood mononuclear cells ( PBMNCs ) from seropositive compared with seronegative subjects . Positive_regulation IL6 TLR7 22751696 2670353 ligation also *resulted* in a diminished [IL-6] response in seropositive individuals as lower frequencies of IL-6 expressing monocytes and mDCs were induced . Positive_regulation IL6 TLR7 22795952 2645460 Even though *induced* TNFa , IL-10 and [IL-6] production , only recombinant TNFa was able to downregulate CD36 . Positive_regulation IL6 TLR7 23246311 2732175 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL6 TLR7 23636665 2805045 Furthermore , in MS-derived PBMCs , *mediated* production of [IL-6] and the ex vivo expression of B-cell activating factor of the TNF family , two crucial cytokines for B-cell differentiation and survival , were induced by IFN-ß . Positive_regulation IL6 TLR7 23843519 2816470 In cultured neurons , activation *induced* [IL-6] and TNF-a expression through Myd88 . Positive_regulation IL6 TLR7 24043893 2851715 In this study , we show that IL-21 enhances TLR induced IgG production , whereas it has no effect on *induced* [IL-6] production by human B cell cultures . Positive_regulation IL6 TLR7 24205068 2864735 We compared *induced* production of pro-interleukin (IL)-1ß , [IL-6] , and tumor necrosis factor (TNF)-a between 2-month-old infants and adults . Positive_regulation IL6 TLR7 24205068 2864742 *induced* production of pro-IL-1ß and [IL-6] in monocytes was lower in 2-month-old infants compared to adults . Positive_regulation IL6 TLR7 24205068 2864761 Lower *induced* production of pro-IL-1ß and [IL-6] in innate immune cells during early infancy likely contributes to suboptimal vaccine responses and infectious diseases susceptibility . Positive_regulation IL6 TLR7 25044064 2956709 Unlike what is seen under hypertonic conditions , XO-derived ROS were selectively required for the *induced* NFAT5 activation and NFAT5 binding to the [IL-6] promoter in RAW 264.7 macrophages under isotonic conditions . Positive_regulation IL6 TNF 10022508 590097 In osteoblast-like MC3T3-E1 cells , we have recently reported that sphingosine 1-phosphate among sphingomyelin metabolites acts as a second messenger for *induced* [interleukin-6 (IL-6)] synthesis . Positive_regulation IL6 TNF 10027341 591440 Both basal and *induced* [IL-6] mRNA levels were dose-dependently lowered by MPA . Positive_regulation IL6 TNF 10037006 557544 However , the role of monoclonal antibodies , directed against these factors , confirmed the *role* of in the [IL-6] production by stromal cells , while any IL-1beta intervention was not shown in our co-culture system . Positive_regulation IL6 TNF 10049519 557562 Generation of inflammatory cytokines in zymosan induced pleurisy in rats : *induces* [IL-6] and cytokine induced neutrophil chemoattractant ( CINC ) in vivo . Positive_regulation IL6 TNF 10049519 557563 These results suggest that CINC produced in the pleural exudate may participate in neutrophil infiltration , that IL-6 induced in the plasma stimulates T-kininogen production , and that endogenous may be partly *involved* in the induction of CINC and [IL-6] in this zymosan inflammation . Positive_regulation IL6 TNF 10049582 592660 Quantitative trait-loci analysis of *induced* induction of [IL-6] and of hypothermia also points to the importance of this locus ( P < 0.0002 and P = 0.017 , respectively ) , more particularly the Cbg and Spi2 loci , in the resistance to TNF . Positive_regulation IL6 TNF 10068127 594064 MIF-A3 does induce secretion of [IL-6] , but does not *induce* secretion of , IL-1beta , and GM-CSF . Positive_regulation IL6 TNF 10329406 613182 The results showed that *induced* p38 MAP kinase activation and [interleukin-6 (IL-6)] production by TRX 14 were less than those by the parental L cells and the control transfected L cells ( Neo-1 ) . Positive_regulation IL6 TNF 10329406 613183 SB 203580 as the specific inhibitor for p38 MAP kinase activity inhibited *induced* [IL-6] production by the parental L cells , indicating that TNF-alpha activated p38 MAP kinase regulates IL-6 production by the cell lines used in this study . Positive_regulation IL6 TNF 10349852 616981 Whereas IL-1beta , , and transforming growth factor-beta mRNA levels remained unchanged , stimulation of astrocytoma cells ( T98G , CB193 , U118MG ) by C3a , C5a , and peptidic C3aR and C5aR agonists *induced* an increase in the [IL-6] mRNA level . Positive_regulation IL6 TNF 10362713 620138 In contrast , ( 200 U/ml ) *induced* [IL-6] at the protein and mRNA levels in both airway epithelial cells and lung fibroblasts . Positive_regulation IL6 TNF 10362713 620139 In WI-38-40 cells , DMSO was not able to suppress [IL-6] production *induced* by . Positive_regulation IL6 TNF 10384135 624765 Involvement of thioredoxin in rheumatoid arthritis : its costimulatory roles in the *induced* production of [IL-6] and IL-8 from cultured synovial fibroblasts . Positive_regulation IL6 TNF 10384135 624767 We thus examined the effect of TRX on the *induced* [IL-6] and IL-8 production using rheumatoid synovial fibroblast cultures . Positive_regulation IL6 TNF 10384135 624771 The extents of [IL-6] and IL-8 production in *response* to were greatly augmented by TRX as compared with TNF-alpha alone . Positive_regulation IL6 TNF 10385526 625568 We show that A20 does not inhibit TNF- induced nuclear translocation and DNA binding of NF-kappaB , although it completely prevents the TNF- induced activation of an NF-kappaB dependent reporter gene , as well as *induced* [IL-6] and granulocyte macrophage-colony stimulating factor gene expression . Positive_regulation IL6 TNF 10391095 626199 In the conditioned medium , marked [IL-6] secretion was *induced* from WI-38 cells by IL-1beta or . Positive_regulation IL6 TNF 10400316 628099 In other studies , we demonstrated that thrombin stimulates [IL-6] synthesis , which depends on intracellular Ca2+ mobilisation in these cells and that *induces* IL-6 synthesis through sphingosine 1-phosphate , a product of sphingomyelin turnover . Positive_regulation IL6 TNF 10400316 628128 On the contrary , C2-ceramide enhanced the *induced* [IL-6] synthesis . Positive_regulation IL6 TNF 10412737 630860 Exposure to VLDL , IDL , LDL , or a high concentration of HDL *enhanced* the secretion of [IL-6] , PDGF-AB , and TGF-beta by mesangial cells , whereas secretion was stimulated by oxidized LDL . Positive_regulation IL6 TNF 10416510 631405 Serum *increased* ( P < 0.0001 ) by 1.37 ( 95 % CI 0.75 , 2.00 ) % x y ( -1 ) , [IL-6] by 2.63 ( 1.75 , 3.52 ) ( P < 0.0005 ) . Positive_regulation IL6 TNF 10452106 637583 SMT inhibited LPS induced nitric oxide release and *increased* IL-1 beta and [IL-6] secretions in AM , but the levels remained unchanged . Positive_regulation IL6 TNF 10454827 626320 These data indicate that produced early after liver I/R *triggers* both its own secretion as well as [IL-6] release by KC during reperfusion while the release of IL-1alpha occurs independent from TNF-alpha . Positive_regulation IL6 TNF 10457265 639287 In addition , testosterone also suppressed *stimulated* [IL-6] mRNA levels by 57 % , while the adrenal androgen dehydroepiandrosterone had no effect . Positive_regulation IL6 TNF 10469279 641084 In addition , IL-17 increased *induced* IL-1alpha , IL-1beta , and [IL-6] mRNA expression in fetal mouse metatarsals and IL-1alpha and IL-6 mRNA expression in MC3T3-E1 cells . Positive_regulation IL6 TNF 10475301 642715 Therefore , in this study , we investigated the efficacy of ketamine on LPS induced TNF-alpha , IL-6 , and IL-8 production and recombinant human ( rh ) *induced* [IL-6] and IL-8 production in human whole blood . Positive_regulation IL6 TNF 10475301 642716 We found that ketamine suppressed lipopolysaccharide induced tumor necrosis factor alpha , interleukin (IL)-6 , and IL-8 production and recombinant human *induced* [IL-6] and IL-8 production in human whole blood . Positive_regulation IL6 TNF 10496964 647242 We show that dissociated GCs repress *induced* [interleukin-6] gene expression by an NF-kappaB dependent mechanism , without changing the expression level of inhibitor kappaB . Positive_regulation IL6 TNF 10504489 648961 ( 0.1 to 100 ng/ml ) *stimulated* a dose dependent increase in [IL-6] production in both renal cell types . Positive_regulation IL6 TNF 10504489 648962 The role of these activations in IL-6 production was confirmed by the ability of both inhibitors SB203580 ( 1 to 30 microM ) and PD98059 ( 0.01 to 10 microM ) to inhibit basal and *stimulated* [IL-6] production in both cell types . Positive_regulation IL6 TNF 10504489 648990 In *response* to , the activation of both pathways leads to [IL-6] production . Positive_regulation IL6 TNF 10516225 652308 Interleukin (IL)-1alpha , IL-1beta , and showed increased mRNA by 30 min after IT LPS instillation , but [IL-6-] and cytokine induced neutrophil chemoattractant mRNAs were not substantially *increased* until 2 h after IT LPS instillation . Positive_regulation IL6 TNF 10542243 563832 We conclude that , within an `` enhanceosome-like '' structure , NF-kappaB is the central mediator of *induced* [IL-6] gene expression , involving CBP/p300 and requiring histone acetyltransferase activity . Positive_regulation IL6 TNF 10549987 565027 Alcohol also affected the paracrine/autocrine induction of cytokine transcripts in neuronal cell cultures , which included enhancing the ability of to *stimulate* [IL-6] transcripts . Positive_regulation IL6 TNF 10552211 565430 The production of [IL-6] in the fibroblast cultures was *stimulated* by ( 0.01-10 nm/ml medium ) in a dose dependent way . Positive_regulation IL6 TNF 10564140 567135 The experiments demonstrate that LPS , TNF-alpha , IL-1beta , and [IL-6] *induce* lowering of P ( if ) when given intravenously or intra-arterially , whereas only , IL-1beta , and IL-6 induce lowering of P ( if ) when given subdermally . Positive_regulation IL6 TNF 10611258 656250 The proteasome inhibitor MG132 ( 0.3 and 3 micromol/l ) also caused a dose dependent decrease in IL-1alpha and *stimulated* [IL-6] ( P < 0.001 and P < 0.001 respectively ) and leukaemia inhibitory factor (LIF) ( P < 0. 001 and P < 0.001 respectively ) production by endometrial epithelial cells . Positive_regulation IL6 TNF 10632674 659818 IL-1beta and strongly *stimulated* [IL-6-type] cytokine release ( except for OSM ) by both OB and BMSC . Positive_regulation IL6 TNF 10653854 663328 It is well known that *induces* [IL-6] production from synovial cells as well as their proliferation . Positive_regulation IL6 TNF 10653854 663331 In addition , the IL-6-sIL-6R complex reduced the TNF-alpha induced proliferation of synovial cells while *induced* their [IL-6] production . Positive_regulation IL6 TNF 10712813 674188 , although ineffective alone , *increased* interleukin-1beta induced [interleukin-6] release in a concentration dependent manner when co-incubated with interleukin-1betafor 18 hr . Positive_regulation IL6 TNF 10712813 674190 However , not *enhance* interleukin-1beta induced [interleukin-6] release if co-incubated with interleukin-1betafor a shorter time ( 6 hr ) . Positive_regulation IL6 TNF 10760263 683514 Previously , we have shown that GCs repress *induced* [IL-6] gene expression by an NF-kappaB dependent nuclear mechanism without changing the DNA binding capacity of NF-kappaB or the expression levels of the cytoplasmic inhibitor of NF-kappaB ( IkappaB-alpha ) . Positive_regulation IL6 TNF 10781614 714395 Like IL-6 , , which activates both NF-kappaB and p38 , also *induced* p38 dependent [IL-6] expression and release and protected myocytes from apoptotis . Positive_regulation IL6 TNF 10781614 714398 mediated [IL-6] *induction* was inhibited by a kinase-inactive form of the MAPKKK , TGF-beta activated protein kinase ( Tak1 ) , which is known to activate p38 and NF-kappaB in other cell types . Positive_regulation IL6 TNF 10795756 689765 CAPAN-1 cells had concentration dependent production of [IL-6] and IL-8 in *response* to both endotoxin and . Positive_regulation IL6 TNF 10795756 689769 CAPAN-2 cells had concentration dependent production of [IL-6] and IL-8 in *response* to . Positive_regulation IL6 TNF 10833370 697685 The *induced* secretion of [IL-6] was inhibited by dexamethasone . Positive_regulation IL6 TNF 10851266 701594 EMSAs indicated that trichostatin A weakly suppressed *induced* NF-kappaB and [NF-IL6] activation . Positive_regulation IL6 TNF 10861753 705325 After 4 weeks of treatment with E ( 2 ) + DHT , a significant increase in transcript levels of IL-4 , IL-5 , [IL-6] , MIP-2 , eotaxin , and iNOS was *detected* , while IL-1beta and transcript levels only increased slightly . Positive_regulation IL6 TNF 10873159 708360 *enhances* mRNA expression and secretion of [interleukin-6] in cultured human airway smooth muscle cells . Positive_regulation IL6 TNF 10878380 708972 The acute-phase response ( APR ) is regulated by , IL-1beta , and [IL-6] *acting* alone , in combination , or in concert with hormones . Positive_regulation IL6 TNF 10903137 712881 Analyses of secreted IL-6 by ELISA and of IL-6 mRNA by reverse transcription-PCR revealed that , whereas HeLa cells produced high levels of [IL-6] in *response* to and IL-1beta , the HTM-29 cell line failed to produce both IL-6 protein and mRNA . Positive_regulation IL6 TNF 10918504 717003 Therefore , we examined the effect of NFkappaB decoy ODN transfection on *induced* endogenous interleukin (IL)-1alpha , IL-1beta , [IL-6] , ICAM-1 and VCAM-1 gene expression as assessed by RT-PCR and Northern blotting . Positive_regulation IL6 TNF 10930297 719780 Since PGE2 has an opposite effect on TNF and IL-6 production , inhibiting that of but *inducing* that of [IL-6] , we investigated the effect of S-KPF on TNF and IL-6 production in vivo following LPS injection . Positive_regulation IL6 TNF 10946312 723056 Reperfusion of the ischemic myocardium is associated with a dramatic inflammatory response leading to release , [IL-6] *induction* , and subsequent neutrophil mediated cytotoxic injury . Positive_regulation IL6 TNF 10954018 724490 In contrast , cellular preenrichment with 18 : 0 , 18 : 1 , or 18 : 3 had no effect on *mediated* production of [IL-6] . Positive_regulation IL6 TNF 11007957 735666 NF-kappa B is the exclusive transcription factor for induction of the [IL-6] gene in *response* to and functions as the final trigger to activate a multiprotein complex , a so-called ` enhanceosome ' , at the level of the IL-6 promoter . Positive_regulation IL6 TNF 11007957 735670 However , activation of NF-kappa B alone is not sufficient for [IL-6] gene induction in *response* to , as inhibition of the coactivated extracellular signal regulated kinase and p38 MAPK pathways blocks TNF mediated gene expression . Positive_regulation IL6 TNF 11034223 740626 Pulmonary [interleukin (IL)-6] , IL-1beta , and levels *increased* significantly postinfection . Positive_regulation IL6 TNF 11104733 756507 *induced* secretion of RANTES and [interleukin-6] from human airway smooth-muscle cells . Positive_regulation IL6 TNF 11104733 756508 Pretreatment of HASM with prostaglandin ( PG ) E ( 2 ) , forskolin , or dibutyryl cAMP inhibited TNF-alpha induced RANTES secretion but increased *induced* [IL-6] secretion . Positive_regulation IL6 TNF 11104733 756518 Together , our data suggest that *induced* [IL-6] and RANTES secretion may be associated with NF-kappaB activation , and that inhibition of TNF-alpha stimulated RANTES secretion and augmentation of IL-6 secretion by increased [ cAMP ] ( i ) in HASM cells occurs via an NF-kappaB independent mechanism . Positive_regulation IL6 TNF 11109968 757086 also *stimulated* release of [IL-6] by these cells . Positive_regulation IL6 TNF 11136824 769867 Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the *induction* of [interleukin (IL)-6] by IL-1 or . Positive_regulation IL6 TNF 11136824 769869 Production of [interleukin (IL)-6] in *response* to IL-1 alpha or was nearly abolished in homozygous mutant ( Shp-2 ( -/ ) - ) fibroblast cells . Positive_regulation IL6 TNF 11165942 782829 The p38 mitogen activated protein kinase pathway regulates [interleukin-6] synthesis in *response* to in osteoblasts . Positive_regulation IL6 TNF 11165942 782831 When added to MG-63 cells , *had* a stimulatory effect on the production of [IL-6] , and this elevation was significantly reduced by SB203580 , a specific p38 MAPK inhibitor . Positive_regulation IL6 TNF 11165942 782906 These results strongly suggest that both p38 MAPK and NF-kappaB are required in *induced* [IL-6] synthesis and that these two TNF-alpha activated pathways can be primarily dissociated . Positive_regulation IL6 TNF 11200059 779755 Inclusion of IL-10 neutralizing antibody in the culture medium significantly ( p < 0.05 ) enhanced *induced* [IL-6] and MIP-2 production by both corneal cell types . Positive_regulation IL6 TNF 11216681 785859 Exogenous also *enhanced* the release of [interleukin-6] ( p < 0.01 ) and transforming growth factor-beta1 ( p < 0.05 ) , whereas the secretion of transforming growth factor-beta1 was increased by insulin-like growth factor-I and prostaglandin E2 as well . Positive_regulation IL6 TNF 11237861 790418 We have recently demonstrated that nuclear factor kappaB (NF-kappaB) mediates the *dependent* expression of the gene encoding [interleukin 6 (IL-6)] in rat thyroid FRTL-5 cells cultured in the presence of thyrotropin ( TSH ) . Positive_regulation IL6 TNF 11237861 790426 Accordingly , *activated* the expression of the [IL-6] gene in the presence of TSH but not in its absence . Positive_regulation IL6 TNF 11244034 792274 Clinical investigations in which the activity of TNF alpha in RA patients was blocked with intravenously administered infliximab , a chimeric anti-TNF alpha monoclonal antibody ( mAB ) , has provided evidence that *regulates* [IL-6] , IL-8 , MCP-1 , and VEGF production , recruitment of immune and inflammatory cells into joints , angiogenesis , and reduction of blood levels of matrix metalloproteinases-1 and -3 . Positive_regulation IL6 TNF 11252722 793972 We demonstrated that ROR alpha is expressed in human primary smooth-muscle cells and that ectopic expression of ROR alpha1 inhibits *induced* [IL-6] , IL-8 and COX-2 expression in these cells . Positive_regulation IL6 TNF 11272279 786000 The results revealed that *up-regulated* NO , PGE2 , and [IL-6] synthesis ; Positive_regulation IL6 TNF 11285305 799845 In addition , Salmonella typhimurium , , and forskolin , known inducers of IL-6 secretion in intestinal epithelial cells , also *stimulate* [IL-6] secretion into the apical compartment . Positive_regulation IL6 TNF 11319753 806834 SB 203580 , a selective inhibitor of p38 MAPK , inhibited IL-1 and *induced* p38 MAPK activity and [IL-6] production ( IC ( 50 ) s 0.3 -- 0.5 microM ) in osteoblasts and chondrocytes . Positive_regulation IL6 TNF 11327082 807517 IL-1beta and , proinflammatory cytokines , induced IL-6 production in a time dependent manner , and PGF2alpha synergistically *enhanced* [IL-6] production induced by IL-1beta and TNFalpha . Positive_regulation IL6 TNF 11327082 807521 IL-6 mRNA was expressed in PGF2alpha stimulated HGF , and PGF2alpha increased [IL-6] mRNA levels *induced* by IL-1beta and . Positive_regulation IL6 TNF 11327386 807613 Our data show that and TGF-beta are able to stimulate the proliferation of human lung fibroblasts in culture , to increase the collagen production of the cells and are both able to *increase* [IL-6] production by lung fibroblasts of patients with silicosis . Positive_regulation IL6 TNF 11336164 809287 IL-8 and [IL-6] secretion could be *stimulated* by IL-1alpha , IL-1beta , , PMA and LPS within 6 h of incubation . Positive_regulation IL6 TNF 11403205 824896 Finally , when CF cells were grown at 27 degrees C ( a culture condition which results in transport of CF transmembrane conductance regulator , CFTR , to the cell membrane and normalization of chloride conductance ) *stimulated* production of [IL-6] and IL-8 reverted to normal . Positive_regulation IL6 TNF 11459775 838700 We therefore examined the effects of the PPARalpha activator fenofibrate and the GR activator dexamethasone on *stimulated* expression of [IL-6] and vascular cell adhesion molecule-1 in vascular endothelial cells . Positive_regulation IL6 TNF 11459775 838704 Both fenofibrate and dexamethasone reduced *induced* [IL-6] production in human vascular endothelial cells , but only fenofibrate reduced TNFalpha stimulated vascular cell adhesion molecule-1 expression in these cells . Positive_regulation IL6 TNF 11494147 846183 also *activates* NF-kappaB and markedly upregulates ( fivefold ) secretion of [interleukin-6 (IL-6)] , a myeloma growth and survival factor , in bone marrow stromal cells ( BMSCs ) . Positive_regulation IL6 TNF 11494331 846206 The [IL-6] secretion of HPEC was *stimulated* by VEGF and , but not by ATP and bradykinin . Positive_regulation IL6 TNF 11554784 859927 *induced* the release of IL-8 ( P < 0.01 ) and [IL-6] ( P < 0.05 ) from the duodenal explants . Positive_regulation IL6 TNF 11562425 862781 Tumor necrosis factor receptor (TNFR) 1 , but not TNFR2 , mediates *induced* [interleukin-6] and RANTES in human airway smooth muscle cells : role of p38 and p42/44 mitogen activated protein kinases . Positive_regulation IL6 TNF 11562425 862792 Using receptor-specific blocking antibodies , we found that TNFR1 primarily regulates *induced* [IL-6] and RANTES secretion and activation of p38 and p42/44 MAPK pathways . Positive_regulation IL6 TNF 11606029 871562 The drug increased the levels of TNF-alpha regulators such as IL-10 and corticosteroids , whereas it inhibited *dependent* [IL-6] production . Positive_regulation IL6 TNF 11696251 894915 [IL6] increased at 7 weeks and *increased* in unstimulated cultures at 3 and 7 weeks but decreased at these times in LPS and SAC stimulated cultures . Positive_regulation IL6 TNF 11728452 884658 Further , IkappaB-alphaM suppressed *stimulated* release of [interleukin-6] and -8 ( IL-6 and IL-8 ) . Positive_regulation IL6 TNF 11764202 887904 T-614 suppressed *induced* production of [IL-6] , IL-8 , and monocyte chemoattractant protein 1 , and also reduced the accumulation of IL-6 and IL-8 mRNA in a concentration dependent manner . Positive_regulation IL6 TNF 11777983 899876 EMSAs demonstrated that IL-17 , IL-1beta , and TNF-alpha induced NF-kappaB activation within 1.5 h after stimulation , and a blockade of NF-kappaB activation by the pyrrolidine derivative of dithiocarbamate and tosyl-phe-chloromethylketone markedly reduced the IL-17- , IL-1beta- , or *induced* [IL-6] gene expression . Positive_regulation IL6 TNF 11777983 899950 Furthermore , IL-17 , IL-1beta , and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs , and specific MAPK inhibitors ( SB203580 , PD98059 , and U0216 ) significantly reduced IL-17- , IL-1beta- , or *induced* [IL-6] secretion , indicating the role of MAPKs in the induction of IL-6 . Positive_regulation IL6 TNF 11786084 901240 BMP-7 represses the basal and *stimulated* expression of the pro-inflammatory cytokines [IL-6] and IL-1beta , the chemokines MCP-1 and IL-8 , and the vasoconstrictor ET-2 in PTEC . Positive_regulation IL6 TNF 11820362 908731 Regulation of *induced* [IL-6] production in MG-63 human osteoblast-like cells . Positive_regulation IL6 TNF 11820362 908732 Therefore , we tested the hypothesis that *induced* [IL-6] production in MG-63 osteosarcoma cells occurs via the p38 mitogen activated protein kinase (MAPK) pathway . Positive_regulation IL6 TNF 11820362 908734 activated p38 MAPK and *stimulated* [IL-6] secretion by MG-63 cells , and pre-incubation of cells with the p38 MAPK inhibitor abrogated TNF-alpha dependent IL-6 secretion . Positive_regulation IL6 TNF 11820362 908749 Transfection of IL-6 full-length and 5-deletion gene promoter reporter constructs indicated that p38 MAPK activation by *enhanced* [IL-6] gene expression , and that the p38 MAPK-responsive region resided in the proximal 260-bp segment . Positive_regulation IL6 TNF 11820362 908785 In conclusion , although p38 MAPK activation by *stimulates* [IL-6] secretion by MG-63 cells , it has opposing effects on c/EBPbeta and NFkappaB activity . Positive_regulation IL6 TNF 11834488 911048 After 20 min , whereas expression further *increased* , [IL-6] and IGF-1 levels progressively reduced to values lower than those observed under moderate stretch and in unstretched ( 5 mmHg ) control myocardium ( IL-6 ) . Positive_regulation IL6 TNF 11853880 913403 Previous studies from our laboratory have shown that *induces* [IL-6] mRNA expression in cultured skeletal muscle cells . Positive_regulation IL6 TNF 11853880 913404 These findings indicate that the effects of on muscle protein synthesis are *mediated* by [IL-6] , but that TNF exerts IL-6 independent effects on proliferation of murine skeletal myoblasts . Positive_regulation IL6 TNF 11856644 914387 Furthermore , both compounds were able to inhibit *induced* IL-1beta , but not [IL-6] , increase . Positive_regulation IL6 TNF 11919083 926008 *induced* secretion of RANTES and [interleukin-6] from human airway smooth muscle cells : modulation by glucocorticoids and beta-agonists . Positive_regulation IL6 TNF 11919083 926010 We found that *induced* [IL-6] gene expression in ASM cells via a nuclear factor (NF)-kappaB dependent pathway , whereas RANTES gene expression was mediated via activation of activator protein (AP)-1 and nuclear factor of activated T cells ( NF-AT ) . Positive_regulation IL6 TNF 11919083 926011 *induced* [IL-6] secretion was only partially inhibited by dexamethasone , yet TNF-alpha induced RANTES secretion was abolished . Positive_regulation IL6 TNF 11919083 926012 beta-Agonists augmented *induced* [IL-6] secretion , reflecting an additive effect of NF-kappaB and CRE response elements on IL-6 gene expression . Positive_regulation IL6 TNF 11919083 926015 Collectively , these data elucidate transcriptional mechanisms mediating *induced* [IL-6] and RANTES secretion from ASM cells , and identify the specific cis- or trans acting elements that determine the differential effects of glucocorticoids and cAMP elevating agents on the expression of these genes . Positive_regulation IL6 TNF 11934972 927928 In addition , *regulates* [IL-6] production . Positive_regulation IL6 TNF 11943316 928695 The objectives of this study were to determine interleukin (IL)-1 beta , IL-2 , IL-4 , IL-5 , [IL-6] , IL-8 , IL-10 , interferon (IFN)-gamma and *induction* in bronchoalveolar lavage (BAL) of control horses and horses with heaves both during remission and exacerbation of the disease , and to determine the effect of therapy with inhaled fluticasone propionate on the cytokine profile of horses with heaves . Positive_regulation IL6 TNF 11959686 931420 PGJ treatment markedly blunted the *induced* increase in leptin , TNF-alpha , and [interleukin-6] gene expression in epididymal adipose tissue . Positive_regulation IL6 TNF 11970911 933278 In addition , pretreatment of cells with N-acetyl-cysteine blocked *induced* [IL-6] release , suggesting that endogenously produced ROS participate in IL-6 production . Positive_regulation IL6 TNF 12008042 940733 The expression of MCP-1 , [IL-6] and MMPs in both DA3-high and CSML-high cells was *up-regulated* by . Positive_regulation IL6 TNF 12039561 949523 This compound is orally active in two acute models of cytokine release ( *induced* [IL-6] and LPS induced TNF ) and a chronic model of arthritis ( 20-day murine collagen induced arthritis ) . Positive_regulation IL6 TNF 12054913 951565 It has recently been reported that *induced* [IL-6] synthesis is amplified by IL-17 in these cells . Positive_regulation IL6 TNF 12060857 952834 Inhibitory effects of somatostatin on *induced* [interleukin-6] secretion in human pancreatic periacinar myofibroblasts . Positive_regulation IL6 TNF 12060857 952836 To elucidate the mechanisms mediating the therapeutic actions of somatostatin on acute pancreatitis , we investigated how somatostatin affects the *induced* [interleukin (IL)-6] and IL-8 secretion from pancreatic myofibroblasts . Positive_regulation IL6 TNF 12060857 952841 Somatostatin dose-dependently inhibited the *induced* [IL-6] secretion . Positive_regulation IL6 TNF 12060857 952843 Northern blot analysis demonstrated that somatostatin decreased the *induced* [IL-6] mRNA expression , and that this effect was completely blocked by the somatostatin antagonist cyclo-somatostatin . Positive_regulation IL6 TNF 12060857 952849 Somatostatin down-regulated the *induced* [IL-6] secretion in human pancreatic periacinar myofibroblasts . Positive_regulation IL6 TNF 12137803 969041 In this investigation , we showed that RU486 , already proved to be an active anti-glucocorticoid and anti-progesterone agent , blocked the inhibition of *stimulated* [interleukin-6 (IL-6)] production by the PPARalpha activator fenofibrate in human umbilical vein ECs . Positive_regulation IL6 TNF 12137803 969042 Transient transfection of bovine aortic ECs with an IL-6 promoter construct demonstrated that RU486 blocked the inhibitory effect of fenofibrate on *induced* [IL-6] promoter activity . Positive_regulation IL6 TNF 12165487 972836 IL-17 enhances the *induced* [IL-6] and IL-8 secretion in human colonic subepithelial myofibroblasts . Positive_regulation IL6 TNF 12183057 977931 In human pancreatic myofibroblasts , interleukin (IL)-17 markedly enhances *induced* [IL-6] secretion through the induction of IL-6 mRNA stabilization . Positive_regulation IL6 TNF 12184542 978131 This study assessed a role for [IL-6] , IL-8 , and in H. pylori *induced* endothelial cytostasis . Positive_regulation IL6 TNF 12184911 978153 Transcription factor [NF-IL6] ( C/EBPbeta ) activates the expression of the mouse MHC class I H2-Kb gene in *response* to via the intragenic downstream regulatory element . Positive_regulation IL6 TNF 12188027 979949 mRNA induction was maximum within 3 h , IL-6 mRNA was gradually induced up to 24 h , and IL-1beta and IL-12 mRNA were highly induced at 24 h . IL-1beta and [IL-6] protein levels also *increased* within 24 h in a dose dependent manner and reached a maximum with 100 microg/ml ginsan . Positive_regulation IL6 TNF 12393542 1035651 *induced* [IL-6] secretion in BMSCs is also inhibited by VX-745 . Positive_regulation IL6 TNF 12475184 1023528 The solution of Abeta ( 5 microM ) formed by 2-h incubation at room temperature *induced* tumour necrosis factor-alpha (TNF-alpha) and [interleukin (IL)-6] levels by 55 and 45 % , respectively , and increased gelatinase B activity by 67 % , while exposure of cells to the ACT/Abeta1-42 mixture ( 1 : 10 molar ratio ACT : Abeta1-42 ) under the same experimental conditions showed no effect on IL-6 levels or gelatinase B activity , but strongly induced ( by 190 % ) , compared to the controls . Positive_regulation IL6 TNF 12557750 1029083 The Saa1 and Saa2 promoters are strongly *induced* by [IL-6] , with synergistic upregulation of Saa2 , but not of Saa1 , by IL-1 or . Positive_regulation IL6 TNF 12591236 1060210 Further , elevating cyclic AMP inhibited *induced* release of [IL-6] , and migration of VSMC . Positive_regulation IL6 TNF 12626436 1079881 Exercise and [IL-6] infusion inhibit endotoxin *induced* production in humans . Positive_regulation IL6 TNF 12668157 1075706 and insulin *induced* [IL-6] production from PBC , but had no effect on adipocytes . Positive_regulation IL6 TNF 12711143 1083225 Soybean isoflavones inhibit *induced* apoptosis and the production of [interleukin-6] and prostaglandin E2 in osteoblastic cells . Positive_regulation IL6 TNF 12740672 1088200 In FMF patients [IL-6] , , sIL-2r , ESR , CRP and fibrinogen levels *increased* with the acute-phase reaction , especially in the attack period . Positive_regulation IL6 TNF 12748169 1113004 Interestingly , *induced* [interleukin (IL)-6] production was nearly abolished in FAK-/- fibroblasts , whereas a normal level of production was obtained in FAK+/- or FAK+/+ fibroblasts . Positive_regulation IL6 TNF 12748169 1113005 Similarly , induced *activation* of activator protein 1 or [NF-IL-6] was not impaired in FAK-/- cells . Positive_regulation IL6 TNF 1279199 202971 As can *increase* the production of IL-1 and [IL-6] and these inflammatory cytokines all enhance HIV-1 gene expression and affect the immune , vascular , and central nervous systems , the activation of TNF by Tat may be part of a complex pathway in which HIV-1 uses viral products and host factors to increase its own expression and infectivity and to induce disease . Positive_regulation IL6 TNF 12823853 1104334 Among these genes we identified the following : *stimulated* gene-6 ( TSG-6 ) , [IL-6] , IL-8 , GRO-beta , and bone morphogenetic protein-6 with an expression 3.6-10.6-fold that in the unstimulated control . Positive_regulation IL6 TNF 12875587 1115135 Addition of RXM at a concentration of 10.0 mg/ml to cell cultures caused reduction of the mRNA expressions of both [IL-6] and RANTES , which were *enhanced* by stimulation in vitro . Positive_regulation IL6 TNF 12889600 1117207 *induces* [interleukin-6] production via extracellular regulated kinase 1 activation in breast cancer cells . Positive_regulation IL6 TNF 12889600 1117210 In conclusion , induced [IL-6] production is *mediated* via ERK1 activation in MDA-MB-231 cells . Positive_regulation IL6 TNF 12911858 1122179 The in plasma may partially *induce* transcription of [IL-6] and IL-8 , which contribute to the CD14 independent increase in level of mRNA for IL-6 and IL 8 . Positive_regulation IL6 TNF 12913922 1129686 stimulation *induced* [IL-6] secretion by RA SFB ( 3-fold ) and OA SFB ( 4-fold ) , as well as MMP-1 secretion ( RA , 85-fold ; Positive_regulation IL6 TNF 12928393 1132008 Decreased production of [IL-6] and KC in *response* to exogenous , in addition to protection from TNF-alpha , suggested that adenoviral infection results in TNF-alpha tolerance . Positive_regulation IL6 TNF 12969251 1139144 NO and , but not IL-6 production appear to be regulated independently , since NOS inhibitors did not decrease TNF-alpha secretion and a neutralizing TNF-alpha antibody did not *reduce* NO production , while employment of NOS inhibitors reduced significantly the secretion of [IL-6] . Positive_regulation IL6 TNF 1311016 178700 Thus , it is difficult to identify the cytokine primarily responsible for a particular biologic effect , since IL-1 and stimulate one another , and both IL-1 and TNF *stimulate* [IL-6] . Positive_regulation IL6 TNF 1314865 185357 PFN failed to inhibit constitutive or *induced* [IL-6] hybridoma proliferative activity , IL-6 protein , or IL-6-specific m-RNA levels . Positive_regulation IL6 TNF 1318227 187977 *mediated* [IL6] gene expression and cytotoxicity are co-inducible in TNF-resistant L929 cells . Positive_regulation IL6 TNF 1318227 187978 These results confirm our earlier conclusions regarding the close relationship between *mediated* [IL6] gene expression and the pathway leading to cytotoxicity . Positive_regulation IL6 TNF 1322305 192133 Synergistic *induction* of [interleukin-6] by and lithium chloride in mice : possible role in the triggering and exacerbation of psoriasis by lithium treatment . Positive_regulation IL6 TNF 1323220 192386 [IL-6] secretion is *stimulated* in a dose dependent manner by IL-1 alpha , , and PDGF . Positive_regulation IL6 TNF 1334048 205816 Both IL-1 and *induced* PCA , reduced TM , and induced [IL-6] production in a dose dependent manner . Positive_regulation IL6 TNF 1334048 205820 INF-gamma inhibited the PCA expression and enhanced the reduction of TM and the production of [IL-6] , which were *induced* by either IL-1 or . Positive_regulation IL6 TNF 13680554 1140809 [Interleukin-6 (IL-6)] and levels *increase* after acute myocardial infarction ( AMI ) in humans . Positive_regulation IL6 TNF 1376041 188247 The secondary rise in [IL-6] production is *dependent* upon the prior production of . Positive_regulation IL6 TNF 1376339 188261 HIV *induced* [IL-6] production ( 500 to 1500 pg ) in the presence of IL-4 , with a slight production of . Positive_regulation IL6 TNF 1386144 193206 Its in vivo effect on C3 secretion might be secondary to the *induced* release of IL-1 and/or [IL-6] . Positive_regulation IL6 TNF 1402392 199577 Tumor cell [IL-6] gene expression is *regulated* by IL-1 alpha/beta and : proposed feedback mechanisms induced by the interaction of tumor cells and macrophages . Positive_regulation IL6 TNF 1402392 199583 It was shown that macrophage products IL-1 alpha , IL-1 beta , and to a lesser extent , , *induced* the tumor cells in vitro to transcribe the [IL-6] gene and release the gene product . Positive_regulation IL6 TNF 1427594 202452 at a low dose ( 10 U/ml ) *stimulated* production of prostaglandin E2 , Mn-superoxide dismutase , [interleukin (IL)-6] and IL-8 by glioblastoma cells . Positive_regulation IL6 TNF 1431212 202865 Unstimulated HDMEC did not produce significant amounts of IL-6 , whereas lipopolysaccharide (LPS) , , and IL-1 beta were potent *inducers* of HDMEC derived [IL-6] production . Positive_regulation IL6 TNF 1431212 202870 In contrast , LPS and induced prolonged stimulation of IL-6 production by HDMEC as IL-6 mRNA transcripts were still detected after 24 h treatment and [IL-6] protein was markedly *increased* at this timepoint . Positive_regulation IL6 TNF 14519761 1174280 Secreted IFNbeta acted as a negative regulator of *induced* [interleukin-6] expression , while IFNbeta augmented TNFalpha induced RANTES ( regulated on activation normal T cell expressed and secreted ) secretion but had little effect on TNFalpha induced intercellular adhesion molecule-1 expression . Positive_regulation IL6 TNF 14551261 1185975 Overexpression of a GR-interacting coactivator peptide blocked transactivation but did not affect transrepression of p65 or *induced* [IL-6] promoter activity . Positive_regulation IL6 TNF 14572152 1155745 In contrast , no difference in LPS- or *induced* production of [interleukin-6] was found . Positive_regulation IL6 TNF 14585994 1159353 We found *induced* p38 MAP kinase activation and [interleukin-6 (IL-6)] production impaired in rip1 ( -/- ) murine embryonic fibroblasts (MEF) but unaffected in traf2 ( -/- ) MEF . Positive_regulation IL6 TNF 14600152 1187498 Because C/EBP family members are known to control IL-6 , we examined whether enhanced C/EBPdelta expression is involved in the cooperative *up-regulation* of [IL-6] by IL-17 and . Positive_regulation IL6 TNF 14607246 1162053 *induced* an increase of [IL-6 receptor (IL-6R)] expression in PC12 cells at 4-6 hr . Positive_regulation IL6 TNF 1463043 206772 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL6 TNF 14657510 1218752 The effects of VIP on basal or *stimulated* production of CCL2 ( MCP-1 , monocyte chemotactic protein 1 ) , CXCL8 [ interleukin (IL)-8 ] , [IL-6] and TNF-alpha were studied by specific ELISAs ( enzyme linked immunosorbent assays ) . Positive_regulation IL6 TNF 14710107 1181240 Uterine and cervical interleukin-1beta and [interleukin-6] were decreased , and uterine *increased* in celecoxib-B . Positive_regulation IL6 TNF 1479760 208184 Additional IL-1 alpha to the culture medium induced 3-4 times higher concentration of IL-6 in the culture supernatant compared with that of non stimulating cells , while exogenous did not *stimulate* [IL-6] production . Positive_regulation IL6 TNF 15003809 1217310 NZM2410 was found to be resistant to endotoxicosis and to produce significantly less *induced* [IL-6] and IL-10 . Positive_regulation IL6 TNF 15034939 1223745 Interleukin (IL)-17 enhances *stimulated* [IL-6] synthesis via p38 mitogen activated protein kinase in osteoblasts . Positive_regulation IL6 TNF 15034939 1223747 It has been reported that IL-17 enhances *stimulated* [IL-6] synthesis in osteoblast-like MC3T3-E1 cells . Positive_regulation IL6 TNF 15034939 1223749 We previously showed that sphingosine 1-phosphate (S1-P) mediates *stimulated* [IL-6] synthesis in these cells . Positive_regulation IL6 TNF 15034939 1223777 SB203580 and PD169316 , specific inhibitors of p38 MAP kinase , significantly reduced the enhancement by IL-17 of *stimulated* [IL-6] synthesis . Positive_regulation IL6 TNF 15034939 1223779 SB203580 and PD169316 inhibited the amplification by anisomycin of the *induced* [IL-6] synthesis . Positive_regulation IL6 TNF 15034939 1223780 Taken together , our results strongly suggest that IL-17 enhances *stimulated* [IL-6] synthesis via p38 MAP kinase activation in osteoblasts . Positive_regulation IL6 TNF 1504836 193904 *induces* [IL-6] production by astrocytes but not by microglia . Positive_regulation IL6 TNF 15102517 1239878 Our findings suggest that elevated plasma levels of might *enhance* LPS stimulated [IL-6] release from circulating monocytes . Positive_regulation IL6 TNF 1516257 196786 Peripheral blood mononuclear cells ( PBMC ) from untreated patients produced IL-1 beta , tumour necrosis factor-alpha (TNF-alpha) and [IL-6] in *response* to mitogenic stimulation with phytohaemagglutinin ( PHA ) , only low levels of IL-1 beta , IL-2 and in response to OvAg , but higher amounts of IL-4 and interferon-gamma (IFN-gamma) in response to OvAg than control individuals . Positive_regulation IL6 TNF 15167972 1253504 Moreover , the inhibitory effects of IVIG on IkappaBalpha degradation , [interleukin-6 (IL-6)] production , and E-selectin expression *induced* by were evaluated by Western blot analysis , ELISA , and flow cytometry , respectively . Positive_regulation IL6 TNF 15167972 1253509 Moreover , IVIG inhibited IkappaBalpha degradation , [IL-6] production , and E-selectin expression *induced* by in CAEC . Positive_regulation IL6 TNF 15211029 1262155 We observed constitutive expression of [interleukin (IL)-6] , IL-8 , granulocyte macrophage colony stimulating factor ( GM-CSF ) , and monocyte chemoattractant protein (MCP)-1 in both human and baboon endothelial cells , and these cytokines were further *induced* by and LPS . Positive_regulation IL6 TNF 15223134 1264755 We show that MPA , like dexamethasone ( dex ) , significantly represses *stimulated* [interleukin-6 (IL-6)] protein production in mouse fibroblast ( L929sA ) cells . Positive_regulation IL6 TNF 15266023 1275866 8-Bromo-cADPr , a cADPr antagonist , significantly augmented *induced* [interleukin-6] secretion , whereas regulated on activation normal T cell expressed and secreted secretion was suppressed . Positive_regulation IL6 TNF 1527383 197554 Finally , IL-1 beta plus *induced* the production of [IL-6] , but not of Ig , by adherent BM cells . Positive_regulation IL6 TNF 1527383 197558 These results suggest that IL-1 beta and produced by adherent BM cells synergistically *induce* early [IL-6] generation , which , in turn , drives BM B cell producers into the high rate Ig-secreting state . Positive_regulation IL6 TNF 15276019 1276756 Pigment epithelium derived factor inhibits *induced* [interleukin-6] expression in endothelial cells by suppressing NADPH oxidase mediated reactive oxygen species generation . Positive_regulation IL6 TNF 15276019 1276775 PEDF inhibited *induced* expression of [IL-6] at both mRNA and protein levels . Positive_regulation IL6 TNF 15276019 1276779 The results demonstrated that PEDF inhibited *induced* NF-kappaB activation and subsequent [IL-6] overexpression in HUVEC by suppressing NADPH oxidase mediated ROS generation . Positive_regulation IL6 TNF 15316669 1286290 IL-1 , but not , can *induce* [IL-6] , bone morphogenic protein 2 (BMP-2) , and cyclooxygenase ( COX-2 ) expression in SW1353 cells . Positive_regulation IL6 TNF 1531845 180415 again , IL-1 , IL-2 , , and IFN-gamma mRNA were abundant , but in addition , IL-3 , [IL-6] , and granulocyte-macrophage colony stimulating factor mRNA were greatly *increased* , suggesting an important role in the recall response . Positive_regulation IL6 TNF 15383283 1298859 Different combinations of site-specific phosphorylations of SRC-3 are required for *induction* of [IL-6] gene expression by as compared to oncogenic transformation of MEFs . Positive_regulation IL6 TNF 1541679 180861 Addition of 17 beta-estradiol in the cultures exerted a dose dependent inhibition of IL-1- , TNF- , and IL-1 + *induced* production of bioassayable [IL-6] . Positive_regulation IL6 TNF 1541679 180862 In addition , estradiol inhibited both *induced* [IL-6] production and osteoclast development in primary bone cell cultures derived from neonatal murine calvaria . Positive_regulation IL6 TNF 15474068 1318824 *induced* the release of [interleukin-6] from endometriotic stromal cells by the nuclear factor-kappaB and mitogen activated protein kinase pathways . Positive_regulation IL6 TNF 15474068 1318825 To examine the involvement of nuclear factor-kappaB (NF-kappaB) and mitogen activated protein kinase (MAPK) in the *induction* of [interleukin-6 (IL-6)] by in endometriotic stromal cells ( ESC ) . Positive_regulation IL6 TNF 15474068 1318842 The NF-kappaB inhibitor ( TPCK ) and MAPK inhibitor ( U0126 ) blocked the *induced* [IL-6] expression . Positive_regulation IL6 TNF 15474068 1318859 These findings demonstrate that NF-kappaB and AP-1 activation is critical for *induced* [IL-6] expression in endometriotic stromal cells . Positive_regulation IL6 TNF 1548355 183812 Interleukin 1 ( alpha and beta ) and all *induced* a significant concentration dependent stimulation of [IL-6] production by decidual cells . Positive_regulation IL6 TNF 15516323 1328540 ( 10ng/ml ) *increased* BSP , [IL-6] and COX-2 mRNA levels after 3h , reaching maximal levels at 12 h . Cbfa1 mRNA levels increased after 3 h , but decreased by 24 h. Osterix , cathepsin B , cathepsin L and TIMP-1 mRNA levels did not change after stimulation with TNF-alpha . Positive_regulation IL6 TNF 15531521 1336086 Stimulation of placenta , adipose tissue , and skeletal muscle with LPS and *resulted* in greater release of [IL-6] and IL-8 , whereas only LPS increased TNF-alpha release from all three tissues . Positive_regulation IL6 TNF 15622478 1349034 IL-1beta- and *induced* IL-8 and [IL-6] secretion was significantly decreased after the first and second LCAP treatments . Positive_regulation IL6 TNF 15642135 1363111 *induced* [IL-6] and OPG production by synoviocytes , which was further increased with patient plasma dilutions and inhibited by infliximab . Positive_regulation IL6 TNF 15665514 1365452 The antidiabetic agent rosiglitazone upregulates SERCA2 and enhances TNF-alpha- and LPS induced NF-kappaB dependent transcription and *induced* [IL-6] secretion in ventricular myocytes . Positive_regulation IL6 TNF 15665514 1365455 Since NF-kappaB dependent pathways , including the upregulation of IL-6 secretion , were shown to protect neonatal rat ventricular myocytes from apoptosis upon TNFalpha stimulation , additional experiments were designed to determine whether rosiglitazone enhances *induced* NF-kappaB dependent transcription and [IL-6] secretion . Positive_regulation IL6 TNF 15665514 1365464 Treatment of neonatal rat ventricular myocytes with 10 micromol/L rosiglitazone enhanced TNF-alpha- and lipopolysaccharide induced NF-kappaB dependent transcription by approximately 1.8- and approximately 1.4-fold respectively , and *induced* [IL-6] secretion by n1.5-fold . Positive_regulation IL6 TNF 15683451 1370625 The lymph node homing chemokine receptor CCR-7 expression was induced by TNF-alpha + IL-1beta + [IL-6] + prostaglandin E2 but was not *induced* by Poly I:C + . Positive_regulation IL6 TNF 15693092 1371525 *induced* increases in [IL-6] , IL-8 , and COX-2 mRNA were suppressed by dexamethasone in both fd-FLS and td-FLS . Positive_regulation IL6 TNF 15731288 1439207 and IL1beta *induced* [IL6] production by normal muscle samples and myoblasts , the action of TNFalpha being more potent on muscle samples . Positive_regulation IL6 TNF 15804596 1390936 A. actinomycetemcomitans clearly *induced* [interleukin (IL)-6] , IL-1beta , and to a minimal extent , mRNA expression . Positive_regulation IL6 TNF 15818692 1393483 Nevertheless , the C43S TRAPS fibroblasts were capable of producing [interleukin-6 (IL-6)] and IL-8 in *response* to . Positive_regulation IL6 TNF 15828923 1394273 TNF-alpha induced IL-8 secretion was also significantly decreased after apheresis , but there was no significant difference in *induced* [IL-6] secretion ( P = 0.052 ) . Positive_regulation IL6 TNF 15829418 1394329 MPA markedly inhibited tumor necrosis factor-alpha (TNFalpha) induced intercellular adhesion molecule-1 ( ICAM-1 ) mRNA and surface expression , suppressed TNFalpha induced neutrophils adhesion to endothelial cells , and reduced *induced* [interleukin-6 (IL-6)] secretion . Positive_regulation IL6 TNF 1582974 187614 IFN-alpha and *induce* an autocrine production of [IL-6] in myeloma-cell lines and make possible the autonomous growth of these cell lines . Positive_regulation IL6 TNF 15843470 1411003 [IL-6] production *induced* by IL-1 , , and IL-17 was specifically inhibited by the c-jun NH ( 2 ) -terminal kinase ( JNK ) inhibitor SP600125 , but not by a selective inhibitor of p38 MAPK , and was moderately increased when the ERK1/2 pathway was inhibited . Positive_regulation IL6 TNF 15868610 1402188 In addition , MTX significantly inhibited the enhancement by IL-17 of *stimulated* [IL-6] synthesis . Positive_regulation IL6 TNF 1596939 188773 also significantly *stimulated* the production of biologically active [IL-6] ( P less than 0.01 ) . Positive_regulation IL6 TNF 15975820 1434696 This inhibitory activity of IL-17 ( IC50=0.2 ng/ml ) was 6-fold more potent than its stimulatory activity on *induced* [IL-6] secretion ( ED50=1.2 ng/ml ) , measured in the same cells . Positive_regulation IL6 TNF 15989427 1429348 The *induced* release of [interleukin-6 (IL-6)] and IL-8 was significantly inhibited by the application of siRNA . p65 . Positive_regulation IL6 TNF 16000387 1447308 In the present study , incubation of AM with unopsonized Pneumocystis organisms was not associated with release of interleukin (IL)-1beta , IL-6 , or ( important cytokines in the host response to Pneumocystis ) and did not *induce* IL-1beta , [IL-6] , or TNF-alpha mRNA transcripts . Positive_regulation IL6 TNF 16006772 1447365 The levels of circulating [interleukin (IL)-6] , IL-8 , macrophage colony stimulating factor ( M-CSF ) and interleukin 1 receptor antagonist ( IL-1ra ) significantly *increased* with the clinical stage of CRC , and the levels of IL-6 , soluble tumor necrosis factor ( sTNF ) receptor type I ( RI ) , soluble interleukin 2 receptor alpha and with tumor grade , while IL-6 , IL-8 , M-CSF , IL-1ra and sTNF RI levels significantly rose with bowel wall invasion . Positive_regulation IL6 TNF 16135414 1454504 Human plasma HDL caused a concentration dependent inhibition of *induced* [IL-6] production in human endothelial cells ( by 58.5+/-1.5 % at 2 mg of HDL-protein/ml ) . Positive_regulation IL6 TNF 16155367 1467440 The two new PPAR-gamma agonists and 15d-PGJ2 also inhibited *induced* [interleukin-6 (IL-6)] and monocyte chemoattractant protein-1 ( MCP-1 ) production in supernatants of TNF-alpha stimulated ECs , whereas ciglitazone and DIM-C-pPhCH ( 3 ) did not decrease TNF-alpha induced expression of these two proteins . Positive_regulation IL6 TNF 16175346 1461824 and IL-1beta are early regulators of the immune response and both *induce* the release of secondary cytokines , such as [IL-6] and IL-8 . Positive_regulation IL6 TNF 1618817 191372 We have previously reported that *enhances* expression of [interleukin-6] , collagenase , plasminogen activator inhibitor-1 , and basic fibroblast growth factor genes in human omental microvascular endothelial ( HOME ) cells in culture . Positive_regulation IL6 TNF 16210331 1468668 Finally , SMl decreases *induced* production of the inflammatory cytokine [IL-6] . Positive_regulation IL6 TNF 16228299 1476727 G-protein coupled receptor agonists differentially regulate basal or *stimulated* activation of [interleukin-6] and RANTES in human airway smooth muscle cells . Positive_regulation IL6 TNF 16228299 1476728 More importantly , such calcium mobilizing agents significantly enhanced *induced* [IL-6] secretion while RANTES secretion was abrogated . Positive_regulation IL6 TNF 16243974 1476848 We demonstrate that CpdA exerts an antiinflammatory potential by down modulating *induced* proinflammatory gene expression , such as [IL-6] and E-selectin , but , interestingly , does not at all enhance glucocorticoid response element-driven genes or induce GR binding to glucocorticoid response element dependent genes in vivo . Positive_regulation IL6 TNF 16279537 1480579 In culture medium with ripe DC the levels of such cytokines as IL-1b , [IL-6] , IL-12 , IFN-gamma , significantly *increased* and the production of IL-4 decreased . Positive_regulation IL6 TNF 1629700 191887 In addition , based on a thymidine incorporation assay , inhibited , but [IL-6] strongly *increased* , the DNA synthesis in SK-N-MC cells , whereas in the SH-SY5Y cell line no such differences were seen . Positive_regulation IL6 TNF 1638523 194446 Since *increases* circulating [IL-6] , some of its effects may be mediated or potentiated by IL-6 . Positive_regulation IL6 TNF 16407046 1513300 We investigated whether HDSMCs are capable of expressing and releasing MCP-1 , [IL-6] and SCF in *response* to IL-4 , IL-13 , IL-1beta and . Positive_regulation IL6 TNF 16413378 1513958 and IL-1beta ( 0.01 to 100 ng/mL ) *induced* secretion of IL-8 , [IL-6] , and RANTES in a dose and time dependent manner . Positive_regulation IL6 TNF 1644898 194905 These results suggest that and IL-1 beta *activate* [IL-6] gene expression in astrocytes by a mechanism ( s ) involving activation of an NF-kappa B-like protein . Positive_regulation IL6 TNF 16499908 1554950 Disruption of microtubule structure with vinblastin and of actin with cytochalasin D did not affect *induced* [IL-6] and IL-8 gene transcription but stabilized IL-8 and IL-6 mRNA . Positive_regulation IL6 TNF 16507601 1581851 consistently , *induction* of [IL-6] by or IL-1beta was much more robust in VDR-/- than in VDR+/- cells , indicating that VDR-/- cells are more susceptible to inflammatory stimulation . Positive_regulation IL6 TNF 1651781 164358 This study shows the in vitro effect of LiCl on the *induced* or interleukin 1 (IL-1) induced expression of [IL-6] , granulocyte-macrophage colony stimulating factor ( GM-CSF ) , IL-3 , IL-2 , and the IL-2 receptor-alpha ( IL-2R alpha ) . Positive_regulation IL6 TNF 1655776 166370 In the present study , we have examined whether the *induced* synthesis of [IL-6] or collagenase in HOME cells is mediated by an inducible growth factor . Positive_regulation IL6 TNF 1657127 168899 Nevertheless , GalN had no influence on clearance or [IL-6] *induction* after mTNF injection ; Positive_regulation IL6 TNF 1657127 168900 Indomethacin and dexamethasone , either of which shows a clear protection against TNF/LPS lethality in normal mice , did not change the clearance of injected mTNF , but both reduced the *induced* [IL-6] levels . Positive_regulation IL6 TNF 16586095 1574803 In contrast , *induced* rapid and substantial increases in expression of the genes encoding [IL-6] , MCP-1 , NGF and TNF-alpha itself ; Positive_regulation IL6 TNF 16586095 1574806 [IL-6] ( transiently ) , MCP-1 , NGF and VEGF release were *stimulated* by , with an accelerating rate of MCP-1 secretion over 24 h . TNF-alpha has rapid and substantial effects on the synthesis of key inflammation related adipokines in human adipocytes , with highly gene-specific responses . Positive_regulation IL6 TNF 16595893 1544730 These results suggest that pitavastatin at a low dose ( 0.1 microM ) inhibits NF-kappaB activation and decreases [IL-6] production *induced* by , and is therefore expected to be a new strategy for treating HCC . Positive_regulation IL6 TNF 16601113 1568693 Interestingly , inhibition of GSK-3beta by antisense oligonucleotides or pharmacological agent ( 10 mm lithium ) potentiated *induced* expression of [IL-6] and MCP-1 by 2-6-fold suggesting that inhibition of GSK-3beta under inflammatory conditions ( exposure to TNF-alpha and IL-1beta ) may contribute to enhanced cytokine expression . Positive_regulation IL6 TNF 1667942 176642 Interleukin 1 and synergistically *increase* the production of [interleukin 6] in human synovial fibroblast . Positive_regulation IL6 TNF 1667942 176672 Both IL-1 and *induced* [IL-6] production by synovial fibroblasts in a dose dependent manner . Positive_regulation IL6 TNF 16684367 1663363 In addition , the NBD peptide decreased *induced* [IL-6] production by human RA synovial tissue biopsies by approximately 42 % ( p < 0.01 ) . Positive_regulation IL6 TNF 16708078 1598861 Moreover , we also demonstrated that blockade via antibody or huTNFR : Fc pretreatment *attenuates* both thrombocytopenia ( > 40 % increase in platelet count ) and [IL-6] expression ( > 80 % reduction ) without affecting interleukin 12 , liver enzymes , hematological indices or vector transduction in a murine model . Positive_regulation IL6 TNF 16750176 1570661 In MC3T3-E1 cells , apigenin dose-dependently ( from 5 to 20 microM ) inhibits *induced* production of the osteoclastogenic cytokines , [IL-6] ( interleukin-6 ) , RANTES ( regulated upon activation , normal T cell expressed and -secreted ) , monocyte chemoattractant protein-1 ( MCP-1 ) and MCP-3 . Positive_regulation IL6 TNF 16803639 1579432 RGD targeted adenovirus delivered the dnIkappaB via alphavbeta3 to become functionally expressed , leading to complete abolishment of *induced* up-regulation of E-selectin , ICAM-1 , VCAM-1 , [IL-6] , IL-8 , VEGF-A and Tie-2 . Positive_regulation IL6 TNF 16859503 1663414 Adhered monocytes , after 3-day preincubation with IL-10 and M-CSF , could produce more IL-1beta and [IL-6] in *response* to in the presence of dibutyryl cAMP , as compared with the cells preincubated with or without IL-10 or M-CSF alone . Positive_regulation IL6 TNF 16871769 1593202 In the treatment of rheumatic diseases are currently used inhibitors and blockade of the IL-1 , in phase of clinical trials or actual registration are agents *blocking* [IL-6] , the antibodies against B cell and inhibition of activation of T-cells by costimulating blockade with CTLA4Ig . Positive_regulation IL6 TNF 1693528 132757 Nuclear run-on analyses showed that IL-1 alpha transcriptionally activated the genes for IL-6 , GM-CSF , and IL-1 beta , while transcriptionally *induced* expression of [IL-6] and IL-1 beta . Positive_regulation IL6 TNF 16936090 1608913 Lipopolysaccharide (LPS) *induced* the release of the proinflammatory cytokine [IL-6] and that of the chemokines G-CSF , MCP-1 , MIP-1beta , and IL-8 as well as surface expression of ICAM-1 by corneal fibroblasts , whereas IL-1beta , , and GM-CSF were not detected in the culture supernatants of cells incubated with or without LPS . Positive_regulation IL6 TNF 16952378 1639506 ( 1-10 ng/ml ) dose-dependently *increased* [interleukin (IL)-6] and plasminogen activator inhibitor-1 ( PAI-1 ) secretion from 3T3-L1 adipocytes , while decreased adiponectin secretion . Positive_regulation IL6 TNF 16954173 1627626 and IFN-gamma *enhanced* ligand induced [IL-6] production in both cell types irrespective of their modulatory effect on respective TLR mRNA levels . Positive_regulation IL6 TNF 16981137 1617023 Phosphatidylinositol 3-kinase/Akt plays a part in *induced* [interleukin-6] synthesis in osteoblasts . Positive_regulation IL6 TNF 16981137 1617024 In the present study , we investigated whether phosphatidylinositol 3-kinase ( PI3-kinase ) /protein kinase B ( Akt ) is involved in *stimulated* [IL-6] synthesis in MC3T3-E1 cells . Positive_regulation IL6 TNF 16981137 1617033 Akt inhibitor , 1L-6-hydroxymethyl-CHIRO-inositol 2- ( R ) -2- O-methyl-3-O-octadecylcarbonate , significantly suppressed the *stimulated* [IL-6] synthesis , but the inhibitory effect was partial . Positive_regulation IL6 TNF 16981137 1617040 Wortmannin and LY294002 significantly reduce the *induced* [IL-6] synthesis . Positive_regulation IL6 TNF 16981137 1617044 A combination of Akt inhibitor and PD98059 suppressed the *induced* [IL-6] synthesis in an additive manner . Positive_regulation IL6 TNF 16981137 1617045 These results strongly suggest that PI3-kinase/Akt plays a role in the *stimulated* [IL-6] synthesis mainly independent of p44/p42 MAP kinase in osteoblasts . Positive_regulation IL6 TNF 17005253 1666313 In contrast , both IL-1beta and highly *induced* [IL-6] secretion in chorion derived cells , demonstrating the overall responsiveness of these cells to these stimuli . Positive_regulation IL6 TNF 17012372 1674159 and IL-1beta *increased* [IL-6] and IL-8 12- to 67-fold with higher levels in IB3 than C38 cells post-TNF-alpha ( P < 0.05 ) . Positive_regulation IL6 TNF 17014668 1629394 [IL-6] levels peaked on POD 1 decreasing to POD 7 , and levels *increased* from PODs 1 to 7 . Positive_regulation IL6 TNF 17035350 1649194 Interestingly , our data suggest that *contributes* , through lectin-saccharide interaction , to the secretion of [IL-6] and NO induced by CCF . Positive_regulation IL6 TNF 17042956 1663522 HNE dose-dependently decreased basal and *induced* [IL-6] expression while inducing COX-2 expression and prostaglandin E2 ( PGE2 ) release . Positive_regulation IL6 TNF 17042956 1663524 Overexpression of IKKalpha increased *induced* [IL-6] production . Positive_regulation IL6 TNF 1705566 152964 The effect does not occur at 0 degrees C and can not be *induced* by IL-2 , [IL-6] , or GM-CSF . Positive_regulation IL6 TNF 17075836 1649907 SMV prevented the increase in NF-kappaB activation and rise in IL-1beta and [IL-6] levels *induced* by , whereas mevalonate and geranylgeranyl pyrophosphate reversed the inhibitory effects of SMV on activation of NF-kappaB and RhoA . Positive_regulation IL6 TNF 17108260 1686000 In contrast to these studies , we found that IFNgamma ( 1000 U/ml ) markedly inhibited *induced* expression of [interleukin (IL)-6] , IL-8 , and eotaxin by 66.29+/-3.33 , 43.86+/-7.11 , and 63.25+/-6.46 % , respectively . Positive_regulation IL6 TNF 17108260 1686002 These genes were also found to be NF-kappaB dependent in that *induced* expression of [IL-6] , IL-8 , and eotaxin was dose-dependently inhibited by the selective IKKbeta inhibitor 4- ( 2'-aminoethyl ) amino-1,8-dimethylimidazo [ 1,2-a ] quinoxaline ( BMS-345541 ) ( 1-30 microM ) . Positive_regulation IL6 TNF 1714729 164892 Under conditions where TNF mediated cytotoxicity was either increased or decreased , depending on addition of activators or inhibitors , we found that the *induced* [IL6] gene expression was likewise enhanced or repressed . Positive_regulation IL6 TNF 1714833 164906 The mRNA was constitutively expressed , and IL-1 ( 10 ( -11 ) M ) and ( 10 ( -7 ) M ) *induced* further mRNA expression within 2 h , which was sustained over 24 h. 1,25 ( OH ) 2D3 ( 10 ( -7 ) M ) , [IL-6] ( 2000 pg/ml ) , and PTH ( 10 ( -9 ) M ) exerted no effects at any time point . Positive_regulation IL6 TNF 17204394 1747177 While the literature predominantly documents the cascade of pro-inflammatory cytokines as beginning with TNF , followed by the stimulation of IL-1 , and finally plus IL-1 *stimulating* the release of [IL-6] , the present findings indicate that a blockade of IL-6 inhibits the gp120 induced elevations of TNF , IL-1 , and IL-6 mRNA in dorsal spinal cord , elevation of IL-1 protein in lumbar dorsal spinal cord , and TNF and IL-1 protein release into the surrounding lumbosacral cerebrospinal fluid . Positive_regulation IL6 TNF 17273796 1691778 We found that curcumin inhibited the expression of *induced* IL-1beta , [IL-6] , and TNF-alpha , but not IL-8 , in TNF-alpha treated HaCaT cells as well as the TNF-alpha induced cyclin E expression . Positive_regulation IL6 TNF 1727819 180934 These results suggest that trophoblast derived *induced* [IL-6] release and then activated the IL-6-R system in trophoblasts to release hCG . Positive_regulation IL6 TNF 1727819 180937 Collectively , trophoblast derived and IL-1 synergistically *regulated* the level of [IL-6] secreted by trophoblasts , the magnitude of which determined the level of hCG released by activating the IL-6-R system in trophoblasts . Positive_regulation IL6 TNF 17298882 1711215 Consistently , *induction* of [IL-6] by or IL-1beta was much more robust in VDR ( -/- ) than in VDR ( +/- ) cells , indicating that VDR ( -/- ) cells are more susceptible to inflammatory stimulation . Positive_regulation IL6 TNF 17314215 1740839 The production of IL-1beta , [IL-6] and IL-8 *induced* by was decreased by pyrrolidine dithiocarbamate ( PDTC ) , a chemical inhibitor of NF-kappaB . Positive_regulation IL6 TNF 17314215 1740841 *induced* production of IL-1beta , [IL-6] and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002 , suggesting that inhibition of Akt activation might inhibit IL-1beta , IL-6 and IL-8 production induced by TNF-alpha . Positive_regulation IL6 TNF 17319110 1497168 At admission , [IL-6] was *detected* in 50 % of the ACS patients and 5 % of the SA patients or control subjects , while was detected in 35 % of the ACS and SA patients but only in 5 % of control subjects . Positive_regulation IL6 TNF 17322026 1726306 Similarly , IL-1beta- and *induced* expression of [IL-6] , IL-8 , granulocyte macrophage-colony stimulating factor ( GM-CSF ) , regulated and activation normal T cell expressed and secreted ( RANTES ) , growth related oncogene alpha , and monocyte chemotactic protein-1 (MCP-1) was also significantly repressed . Positive_regulation IL6 TNF 17390058 1716115 These results suggest that pitavastatin at low dose ( 1 microM ) inhibits NF-kappaB activation and decreases [IL-6] production *induced* by . Positive_regulation IL6 TNF 17404287 1721954 We previously demonstrated that genistein suppresses *induced* NF-kappaB dependent [IL-6] gene expression in cancer cells by interfering with the mitogen- and stress activated protein kinase 1 activation pathway . Positive_regulation IL6 TNF 17413040 1742227 Inhibitors of JAK , p38 , and NF-kappaB revealed that these signaling pathways are indispensable for the plasmin mediated and [IL-6] *induction* . Positive_regulation IL6 TNF 17416199 1722588 Apigenin increases osteoblastic differentiation and inhibits *induced* production of [interleukin-6] and nitric oxide in osteoblastic MC3T3-E1 cells . Positive_regulation IL6 TNF 17416199 1722589 The effect of apigenin on the *induced* production of [IL-6] and nitric oxide ( NO ) in osteoblasts was examined . Positive_regulation IL6 TNF 17416199 1722590 Treatment with apigenin ( 10 microM ) decreased the *induced* production of [IL-6] and NO in osteoblasts . Positive_regulation IL6 TNF 17438336 1749084 *stimulated* FAK catalytic activation and [IL-6] production were inhibited by FAK N-terminal but not FAK C-terminal domain overexpression . Positive_regulation IL6 TNF 17438336 1749111 Constitutively activated MAPK kinase-1 ( MEK1 ) expression in FAK ( -/- ) and A549 FAK short hairpin RNA expressing cells rescued *stimulated* [IL-6] production . Positive_regulation IL6 TNF 17438336 1749115 Inhibition of Src protein-tyrosine kinase activity or mutation of Src phosphorylation sites on FAK ( Tyr-861 or Tyr-925 ) did not affect *stimulated* [IL-6] expression . Positive_regulation IL6 TNF 17438336 1749120 Moreover , analyses of Src ( -/- ) , Yes ( -/- ) , and Fyn ( -/- ) fibroblasts showed that Src expression was inhibitory to *stimulated* [IL-6] production . Positive_regulation IL6 TNF 17502871 1739970 This study investigated the effects of murine p75-Fc , a soluble TNF receptor protein , on *induced* [IL-6] production in mice . Positive_regulation IL6 TNF 17502871 1739972 Mice treated with 5 and 15 mg/kg murine p75-Fc demonstrated complete inhibition of *induced* [IL-6] production . Positive_regulation IL6 TNF 17502871 1739974 Murine p75-Fc ( 1.5 mg/kg ) resulted in a partial but significant reduction of *induced* [IL-6] production . Positive_regulation IL6 TNF 17502871 1739976 In conclusion , murine p75-Fc completely inhibits *induced* [IL-6] production in mice . Positive_regulation IL6 TNF 17513458 1772844 Recombinant *induced* [IL-6] production by lung monocytic cells exposed to intra-amniotic endotoxin but not in control cells . Positive_regulation IL6 TNF 17572510 1774273 This protection occurs without decreasing global activity of TNF receptors since IL-10 does not impair *induced* [IL-6] synthesis or ERK1/2 phosphorylation . Positive_regulation IL6 TNF 17612514 1786758 Mechanism of *induced* IL-1alpha , IL-1beta and [IL-6] expression in human cardiac fibroblasts : effects of statins and thiazolidinediones . Positive_regulation IL6 TNF 17612514 1786761 Pharmacological inhibitors and receptor neutralizing antibodies established that both *induced* [IL-6] and IL-1beta expression was mediated via the TNFRI receptor and p38 mitogen activated protein kinase (MAPK) , phosphoinositide 3-kinase (PI3K)/Akt and nuclear factor (NF)-kappaB pathways . Positive_regulation IL6 TNF 17612514 1786764 Neither statins ( simvastatin , fluvastatin ) nor TZDs ( ciglitazone , rosiglitazone , troglitazone ) had inhibitory effects on *induced* [IL-6] secretion or IL-1alpha/beta mRNA expression ; Positive_regulation IL6 TNF 17612514 1786766 Our data provide important insights into the regulation of pro-inflammatory cytokine expression in human cardiac fibroblasts and suggest that the myocardial anti-inflammatory effects of statins and TZDs are not due to inhibition of *induced* IL-1 or [IL-6] expression by cardiac fibroblasts . Positive_regulation IL6 TNF 17854477 1795898 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving *dependent* [interleukin-12] induction . Positive_regulation IL6 TNF 17891168 1818797 Similarly , H ( 3 ) and H ( 4 ) receptor agonists did not affect *induced* NF-kappaB dependent transcription , or [IL-6] and IL-8 release at concentrations below 10 microM . Positive_regulation IL6 TNF 17947492 1814264 Low nanomolar concentrations of 4204 blocked the ability of lipopolysaccharide and to *induce* the release of nitric oxide and [interleukin 6] and the degradation of IKBalpha in RAW264.7 macrophage-like cells . Positive_regulation IL6 TNF 1796655 176329 It will focus on interleukin-1 (IL-1) , IL-1 *inhibitors* , , TNF inhibitors , [Interleukin-6 (IL-6)] , colony stimulating factors (CSF's) , Interferon-gamma (IFN-gamma) , growth factors , eicosanoids and prostaglandins , all of which are important in the effector phase of tissue destruction . Positive_regulation IL6 TNF 17967442 1826508 Only IL-1alpha , but not , *induced* [IL-6] in the IL-1alpha/beta/TNFalpha KO mouse brain , while both cytokines induced cyclooxygenase (Cox)-2 . Positive_regulation IL6 TNF 18029463 1860725 Plasma levels increased from 0.7 +/- 0.04 to 16.7 +/- 1.8 pg/ml , and plasma [IL-6] *increased* from 1.0 +/- 0.2 to 9.2 +/- 1.0 pg/ml ( P < 0.05 ) after 4-h rhTNF-alpha infusion . Positive_regulation IL6 TNF 18070744 1834096 Recombinant and LPS synergistically *up-regulated* [IL-6] production in adipocytes . Positive_regulation IL6 TNF 18097057 1847509 Activation of Rho kinase was required for JNK dependent [IL-6] secretion *induced* by . Positive_regulation IL6 TNF 1812993 177392 Both also *augmented* [interleukin-6] production , but less potently than interleukin-1 . Positive_regulation IL6 TNF 18162526 1883101 Furthermore , although TNFalpha increased IL-6 mRNA and protein expression , [IL-6] did not *mediate* the effects of on cell surface GLUT4 levels , which also did not require de novo protein synthesis . Positive_regulation IL6 TNF 18187550 1883644 furthermore strongly *enhanced* expression and/or synthesis of other inflammatory molecules , namely [IL-6] and cyclooxygenase-2 . Positive_regulation IL6 TNF 18195163 1863347 *induced* complement C3 and [interleukin-6] expression in VSMCs . Positive_regulation IL6 TNF 18236210 1839463 Mechanism of crosstalk inhibition of [IL-6] signaling in *response* to LPS and . Positive_regulation IL6 TNF 18236210 1839466 Analysis of suppressor of cytokine signalling 3 ( SOCS3 ) -deficient macrophages reveal that SOCS3 is necessary but surprisingly , not sufficient for the complete crosstalk inhibition of [IL-6] signaling *induced* by LPS and . Positive_regulation IL6 TNF 18252806 1895864 Interestingly , MEK , p38 , and IKK inhibitors block *induced* IL-8 , [IL-6] , and GM-CSF secretion and 12z invasion , whereas the PI3K inhibitors do not . Positive_regulation IL6 TNF 18291623 1878550 The plaa ( high ) cells produced significantly more PGE ( 2 ) and [interleukin (IL)-6] compared to plaa ( low ) cells in *response* to . Positive_regulation IL6 TNF 18314542 1931898 We have found that corticosteroids do not act at the transcriptional level to reduce *induced* [IL-6] gene expression . Positive_regulation IL6 TNF 18314542 1931899 Rather , corticosteroids inhibit *induced* [IL-6] secretion by reducing the stability of the IL-6 mRNA transcript . Positive_regulation IL6 TNF 18314542 1931916 SB203580 + TNF-alpha , t(1/2) = 1.5 h ) , exogenous expression of MKP-1 significantly inhibits *induced* [IL-6] secretion and MKP-1 siRNA reverses the inhibition of TNF-alpha induced IL-6 secretion by dexamethasone . Positive_regulation IL6 TNF 1849793 155474 *induced* the secretion of [interleukin 6] in these cells , additionally showing that functional TNF signaling in these cells indeed takes place , but does not lead to cell lysis under normal conditions . Positive_regulation IL6 TNF 1849935 155486 In addition , we demonstrate that the IL-1 induced desensitization was only observed when a functioning liver was present , that IL-1 pretreated animals did not show decreased numbers of hepatocyte TNF receptors , and that the amount of *induced* [IL-6] was not reduced . Positive_regulation IL6 TNF 18502965 1917762 Constitutive mRNA expression of IL-6 , IL-11 , and leukemia inhibitory factor (LIF) , but not of oncostatin M (OSM) , was demonstrated , as was concentration dependent *stimulation* of [IL-6] and LIF mRNA and of protein by IL-1beta and . Positive_regulation IL6 TNF 18507686 1958429 In cultured BEC , TNF-alpha , interleukin (IL)-1beta , [IL-6] , and interferon-gamma *induced* the expression of CDX2 mRNA , though only additionally induced the expression of MUC2 mRNA . Positive_regulation IL6 TNF 18515973 2010432 Whereas *activated* [IL-6] promoter , which was impaired by p38 MAPK inhibitors or by mutation in the NF-kappaB binding site within the promoter region , 7-ketocholesterol did not affect IL-6 promoter activity . Positive_regulation IL6 TNF 18552402 1945962 Expression of [IL-6] and leukemia inhibitory factor (LIF) was *induced* by in wild-type and JNK2-null myoblasts . Positive_regulation IL6 TNF 18565117 1959177 In contrast , PP DC produced [IL-6] only in *response* to E. coli , little IL-10 and no , and this low cytokine production was not due to inhibition by IL-10 or TGF-beta . Positive_regulation IL6 TNF 18597869 2059259 Metformin inhibits *induced* IkappaB kinase phosphorylation , IkappaB-alpha degradation and [IL-6] production in endothelial cells through PI3K dependent AMPK phosphorylation . Positive_regulation IL6 TNF 18597869 2059273 The effects of metformin on *induced* [IL-6] production were investigated . Positive_regulation IL6 TNF 18597869 2059274 TNF-alpha increased IL-6 secretion by HUVEC in a dose dependent manner but inhibitors of NF-kappaB abolished the *induced* [IL-6] production . Positive_regulation IL6 TNF 18597869 2059275 Pre-treatment with metformin ( 100-1000 micromol/L ) also inhibited *induced* [IL-6] production , phosphorylation of IkappaB kinase (IKK) alpha/beta and IkappaB-alpha degradation . Positive_regulation IL6 TNF 18597869 2059278 AICAR , a direct AMPK activator , had inhibitory effects on *induced* [IL-6] production , similar to that of metformin . Positive_regulation IL6 TNF 18597869 2059279 Transfection of siRNA against alpha1-AMPK eradicated the inhibitory effects of metformin on *induced* [IL-6] , implying the essential role of AMPK . Positive_regulation IL6 TNF 18597869 2059281 Metformin had anti-inflammatory effects on endothelial cells and inhibited *induced* IKKalpha/beta phosphorylation , IkappaB-alpha degradation and [IL-6] production in HUVEC . Positive_regulation IL6 TNF 18611594 290016 IL-1alpha and *induce* the secretion of [IL-6] and IL-8 and the upregulation of mRNAs for IL-1alpha , IL-1beta , IL-6 and IL-8 . Positive_regulation IL6 TNF 18615474 2010592 Analyzing functional properties of cells directly adhered to biomaterial revealed nonproliferative cells , which were capable of inflammatory stimulation in terms of *induced* increase in [interleukin-6] secretion and adhesion of inflammatory cells . Positive_regulation IL6 TNF 1863822 164003 induced no detectable amounts of IL-1 ( less than 0.01 U ) in young or old cartilage but did *induce* [IL-6] production . Positive_regulation IL6 TNF 18663129 1942895 Serum levels of *induced* [IL-6] and nitric oxide metabolites were significantly reduced in mice deficient in the IL-17R . Positive_regulation IL6 TNF 18684450 2059328 Interleukin-10 attenuates *induced* [interleukin-6] production in endometriotic stromal cells . Positive_regulation IL6 TNF 18684450 2059333 Addition of IL-10 suppressed the expressions of [IL-6] *induced* by and IL-10 induced the phosphorylation of STAT3 in endometriotic stromal cells . Positive_regulation IL6 TNF 18684450 2059335 Interleukin-10 attenuates *induced* [IL-6] synthesis via NF-kappaB and MAPK pathways in endometriotic cells.. Positive_regulation IL6 TNF 18700232 1967917 In lung cell cultures both particle types *induced* release of [IL-6] and IL-1beta , whereas was only detected upon exposure to St Louis particles . Positive_regulation IL6 TNF 1873476 165283 IL-1 alpha and markedly *induced* steady state levels of [IL-6] at 20 h in serum-free conditions , whereas transforming growth factor-beta ( TGF-beta ) , epidermal growth factor , and 10 % fetal calf serum did not . Positive_regulation IL6 TNF 18755151 1975283 In addition , we found that IFNgamma and also increased IL-6 expression by BMSCs , and [anti-IL-6] further *increased* the killing of tumor cells by BMSCs . Positive_regulation IL6 TNF 18792875 1963747 *induces* production of [IL-6] and it has been suggested that a causal relationship exists between endothelial dysfunction and these cytokines . Positive_regulation IL6 TNF 19026986 2017156 Furthermore , knockdown of Foxo1 as well as C/EBPbeta inhibits *induced* expression of MCP-1 and [IL-6] in 3T3-L1 adipocytes . Positive_regulation IL6 TNF 1905495 161573 Cytokines such as interleukin 1 (IL-1) , , and [interleukin 6 (IL-6)] *mediate* a variety of host responses to trauma and infection , including skeletal muscle proteolysis . Positive_regulation IL6 TNF 19090831 2003807 Exposure to one or more of the oils at concentrations of < or=0.002 % v/v resulted in a dose responsive reduction in the production of proinflammatory cytokines [IL-6] and , regulatory cytokine IL-10 , Th1 cytokine IFN-gamma and Th2 cytokines IL-5 and IL-13 by PHA *stimulated* mononuclear cells . Positive_regulation IL6 TNF 19107859 2060669 We then examined the effect of PE on the *induced* production of [interleukin-6 (IL-6)] and nitric oxide ( NO ) in osteoblasts . Positive_regulation IL6 TNF 1918953 168431 IL-1 alpha and are also potent *inducers* of [IL-6] production in these cells , the order of potency being IL-1 alpha greater than Onco M greater than TNF-alpha . Positive_regulation IL6 TNF 1918983 168451 Sequential stimulation of THP-1 cells by IFN-gamma and subsequently by did not *allow* [IL-6] gene induction , suggesting that IFN-gamma and TNF-alpha induced or activated different signaling factors which should act together to trigger IL-6 gene transcription . Positive_regulation IL6 TNF 19201813 2049776 Whereas *enhanced* basal secretion of [IL-6] ( 57 +/- 3 % ) , ozone exposure at 0.6 ppm for 6 h augmented IL-6 levels in basal ( 41 +/- 3 % ) and TNF- ( 50 +/- 5 % ) primed cocultures compared with that derived from NHBE or ASM monolayers alone . Positive_regulation IL6 TNF 19273239 2045828 released from ischemic heart after acute MI *increases* the production of other cytokines such as interleukin-1 (IL-1) , [interleukin-6 (IL-6)] and adhesion molecules such as intercellular adhesion molecule-1 ( ICAM-1 ) . Positive_regulation IL6 TNF 19296424 2051768 A reduction of *induced* [IL-6] release after treatment with hyaluronic acid and chondroitin sulfate was observed , indicating the anti-inflammatory action of the preparation . Positive_regulation IL6 TNF 19326443 2100470 The adult injured striatum exhibited a rapid induction of all cytokines analyzed , but the aged injured striatum showed a weak induction of cytokine expression : IL-1beta showed no injury induced changes at any time , presented a late induction at 5 days after lesioning , and [IL-6] was only *induced* at 6 hr after lesioning . Positive_regulation IL6 TNF 19404936 2075166 Specific alpha7nAChR agonists reduced alpha *induced* [IL-6] and IL-8 production by FLS . Positive_regulation IL6 TNF 19410630 2089690 By transfection of TAK1 siRNA , *induced* phosphorylation of IkappaBalpha , JNK1/2 , and p38MAPK , as well as [IL-6] or IL-8 expression , were repressed . Positive_regulation IL6 TNF 19427347 2106768 Involvement of Rho-kinase in *induced* [interleukin-6] release from C6 glioma cells . Positive_regulation IL6 TNF 19427347 2106771 *stimulated* [interleukin (IL)-6] release and induced the phosphorylation of myosin phosphatase targeting subunit ( MYPT)-1 , a Rho-kinase substrate . Positive_regulation IL6 TNF 19427347 2106775 Although IkappaB inhibitor suppressed the *induced* [IL-6] release , the Rho-kinase inhibitors did not affect the TNF-alpha induced IkappaB phosphorylation . Positive_regulation IL6 TNF 19427347 2106802 The *induced* [IL-6] release was suppressed by SB203580 , a p38 MAPK inhibitor , or SP600125 , a SAPK/JNK inhibitor , but not by PD98059 , a MAP kinase/extracellular signal regulated kinase kinase inhibitor . Positive_regulation IL6 TNF 19427347 2106803 Therefore , we investigated the involvement of Rho-kinase in the *induced* [IL-6] release from rat C6 glioma cells . Positive_regulation IL6 TNF 19427347 2106806 These results strongly suggest that Rho-kinase regulates the *induced* [IL-6] release at a point upstream from p38 MAPK and SAPK/JNK in C6 glioma cells . Positive_regulation IL6 TNF 19465513 2107379 *induced* eotaxin , RANTES , and [IL-6] as well as PDGF-BB induced IL-6 expression was inhibited by DMF and by dexamethasone from asthmatic and nonasthmatic ASMC , but the combination of both drugs showed no glucocorticoid sparing effect in either of the two groups . Positive_regulation IL6 TNF 19472186 2085576 , but not TPA , *increased* [IL-6] and MCP-1 mRNA levels , Next , we investigated the effects of ligands which activate c/nPKC . Positive_regulation IL6 TNF 19489038 2128380 We first determined that the C/EBPbeta-C overexpression or siRNA mediated C/EBPbeta depletion decreased *induced* promoter activities of Bfl-1 , [IL-6] , and IL-8 genes . Positive_regulation IL6 TNF 19489038 2128386 Conversely , overexpression of C/EBPbeta-A in LNCaP cells increased resistance to TNF induced cell death and *induced* promoter activities of [IL-6] and Bfl-1 . Positive_regulation IL6 TNF 19514423 2092706 Patients with highly active hepatitis and maximal morphological changes in the liver had significant lowering of NDV induced production of IFN-alpha , IFN-gamma , TNF-alpha , [IL-6] and PGA *induced* production of . Positive_regulation IL6 TNF 19523846 2109024 Scabies inhibited the IL-1alpha and IL-1beta induced secretion of IL-6 , while a combination of scabies and histamine or LTB4 reduced the *induced* secretion of [IL-6] . Positive_regulation IL6 TNF 19535263 2109677 Although IL-6 failed to induce CCL20 , *induced* [IL-6] enhanced the production of CCL20 in an autocrine/paracrine manner . Positive_regulation IL6 TNF 19542367 2103689 In conclusion , PGE ( 2 ) differentially affects *induced* mRNA expression of proinflammatory [IL-6] and prodestructive MMP-1 regarding the usage of EP receptors and the dependency on cAMP . Positive_regulation IL6 TNF 19575800 2111553 For both NCI-H292 and NHBE cells , low arginine concentrations enhanced basal epithelial IL-6 and IL-8 production and synergized with *induced* [IL-6] and IL-8 production . Positive_regulation IL6 TNF 19580863 2142575 In this study we investigated the *role* of IL-1 beta , and COX2 in silica induced regulation of [IL-6] release and pneumocyte loss in various mono- and co-cultures of monocytes , pneumocytes and endothelial cells . Positive_regulation IL6 TNF 19655312 2132522 All three studied classes of HBA blocked the *induced* production of the cytokine [IL6] , and inhibited the transactivation of the pro-inflammatory transcription factors nuclear factor kappa B (NF-kappaB) , activator protein-1 (AP-1) , and cAMP-response element binding protein ( CREB ) . Positive_regulation IL6 TNF 19671412 2119502 ( 1 microg/L ) strongly *induced* the production of [IL-6] and IL-8 as compared with the control serum in A549 cells , and the induced cytokine production was significantly suppressed by 15 % serum containing Feiyanning Decoction ( P < 0.01 ) . Positive_regulation IL6 TNF 19671412 2119504 Feiyanning Decoction can inhibit [IL-6] and IL-8 production *induced* by . Positive_regulation IL6 TNF 19686583 2138961 IL-17 and synergistically *induced* granulocyte chemotactic protein-2 ( GCP-2 ) , [IL-6] and receptor activator of NFkappaB ligand ( RANKL ) in MEF . Positive_regulation IL6 TNF 19697035 2258166 The level of [IL-6] expression was strongly increased in both FLSs and THP-1 macrophages in *response* to IL-1beta and , but the level by TNF-alpha was less than that by IL-1beta . Positive_regulation IL6 TNF 19702865 2247684 rhamnosus *induced* higher levels of TNF-alpha , [IL-6] and IL-12 but inhibited IL-10 production , whereas its mucous variant induced low or no and IL-6 . Positive_regulation IL6 TNF 19710092 2319435 Removal of from the THP-1 culture supernatant prior to HUVEC stimulation *resulted* in a decrease in NF-?B activity , expression of adhesion molecules , as well as [IL-6] secretion . Positive_regulation IL6 TNF 19726342 2134030 induced the activation of NF-kappaB and *increased* the expressions of [IL-6] and sICAM-1 in HUVECs . Positive_regulation IL6 TNF 19726342 2134033 Astragalus Membranaceus Injection can inhibit the *induced* expression of [IL-6] and sICAM-1 by suppressing NF-kappabeta activation , suggesting its protective effect on the endothelial function . Positive_regulation IL6 TNF 19734209 2139528 In vitro , Tir8 ( -/- ) dendritic cell precursors acquired higher allostimulatory activity and released more [IL-6] upon *stimulation* with a TLR4 ligand and than Tir8 ( +/+ ) cells , which may explain the increased frequency of antidonor-reactive T cells and the block of regulatory T cell formation in recipients of a Tir8 ( -/- ) kidney . Positive_regulation IL6 TNF 19776225 2232018 In contrast , overexpression of 11 beta-HSD1 further augmented *induced* iNOS , [IL-6] , and MCP-1 expression . Positive_regulation IL6 TNF 19779981 2141182 In all groups , the serum creatinine and blood urea nitrogen ( BUN ) levels were observed to be within normal limits , while the lactate dehydrogenase and alpha-1 microglobulin levels statistically significantly increased when time points were compared with beginning values ( p < 0.05 ) . Furthermore , cystatin-C levels were observed to be increased after the HS ( p < 0.05 ) , but returned to the normal level after resuscitation in all the study groups . [Interleukin (IL)-6] and levels were *increased* in all the rabbits after HS ( p < 0.05 ) , and there were no significant differences among the study groups after resuscitation ( p > 0.05 ) . Positive_regulation IL6 TNF 19786552 2147706 Of particular interest , *induced* expression of cytokines/chemokines , such as [IL-6] and CXCL-2 , was impaired in FAN-deficient cells . Positive_regulation IL6 TNF 19810018 2168617 Furthermore , naringin suppressed *mediated* release of [interleukin-6] and -8 ( IL-6 and IL-8 ) . Positive_regulation IL6 TNF 1984481 152099 The rise in was *followed* by a rise in plasma [IL-6] ( 27 +/- 12.8 ng/ml ) , peaking 30-90 min thereafter . Positive_regulation IL6 TNF 19879324 2197030 p70 S6 kinase limits *induced* [interleukin-6] synthesis in osteoblast-like cells . Positive_regulation IL6 TNF 19879324 2197031 In the present study , we investigated whether p70 S6 kinase is involved in *stimulated* [IL-6] synthesis in MC3T3-E1 cells . Positive_regulation IL6 TNF 19879324 2197032 Rapamycin , an inhibitor of p70 S6 kinase , which attenuated the phosphorylation of p70 S6 kinase induced by TNF-alpha , significantly amplified the *stimulated* [IL-6] synthesis . Positive_regulation IL6 TNF 19879324 2197033 The amplification by rapamycin of *induced* [IL-6] synthesis was reduced by PD98059 , a specific inhibitor of MEK1/2 , or Akt inhibitor . Positive_regulation IL6 TNF 19879324 2197037 Taken together , these results strongly suggest that p70 S6 kinase limits the *stimulated* [IL-6] synthesis at a point upstream from p44/p42 MAP kinase and Akt in osteoblast-like cells . Positive_regulation IL6 TNF 20007578 2174980 In human pulmonary microvascular ECs , AR activity was required for *induced* activation of the Rho kinase/MKK4/JNK pathway and [IL-6] production , but not p38 activation or ICAM-1 expression . Positive_regulation IL6 TNF 20053934 2225389 stimulation *induced* production of inflammatory cytokines such as [IL-6] and IL-8 in RSF , and the extent of IL-6 and IL-8 induction was dramatically reduced by CHPD under noncytotoxic concentrations . Positive_regulation IL6 TNF 20082310 2212574 FAK activation is required for *induced* [IL-6] production in myoblasts . Positive_regulation IL6 TNF 20082310 2212575 *caused* concentration dependent increases in [IL-6] production . Positive_regulation IL6 TNF 20082310 2212590 Our results suggest that *increased* [IL-6] production in myoblasts via the FAK/PI3K/Akt and NF-kappaB signaling pathway . Positive_regulation IL6 TNF 20100571 2213004 We have observed that treatment of human 1321N1 astrocytes with the beta-adrenergic agonist isoproterenol synergistically enhanced *induced* expression of the cytokine [IL-6] . Positive_regulation IL6 TNF 2012180 156669 Interleukin-1 beta and *induce* gene expression and production of leukocyte chemotactic factors , colony stimulating factors , and [interleukin-6] in human mesangial cells . Positive_regulation IL6 TNF 2012180 156681 Similarly IL-1 beta and *induced* the [interleukin-6 (IL-6)] gene and active secretion of its mature protein . Positive_regulation IL6 TNF 20157051 2221863 C21 dose-dependently ( 1 nM to 1 micromol/L ) reduced *induced* [interleukin 6] levels in primary human and murine dermal fibroblasts . Positive_regulation IL6 TNF 20188080 2242932 It was also observed that polyphenolic acetates inhibit *mediated* release of [IL-6] from peripheral blood mononuclear cells . Positive_regulation IL6 TNF 20205746 2229734 Mechanisms of *induced* [interleukin-6] synthesis in glioma cells . Positive_regulation IL6 TNF 20205746 2229735 *induces* [IL-6] release from rat C6 glioma cells through the inhibitory kappa B ( IkappaB ) -nuclear factor kappa B (NFkappaB) pathway , p38 mitogen activated protein (MAP) kinase and stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) . Positive_regulation IL6 TNF 20205746 2229736 The present study investigated the mechanism of *induced* [IL-6] release in more detail than has previously been reported . Positive_regulation IL6 TNF 20205746 2229751 The Janus family of tyrosine kinase (JAK) inhibitor I , an inhibitor of JAK 1 , 2 and 3 , attenuated TNF-alpha induced phosphorylation of STAT3 and significantly reduced *stimulated* [IL-6] release . Positive_regulation IL6 TNF 20205746 2229760 Apocynin , an inhibitor of NADPH oxidase that suppresses intracellular reactive oxygen species , significantly suppressed *induced* [IL-6] release and mRNA expression . Positive_regulation IL6 TNF 20205746 2229768 These results strongly suggest that *induces* [IL-6] synthesis through the JAK/STAT3 pathway in addition to p38 MAP kinase and SAPK/JNK in C6 glioma cells , and that phosphorylation of NFkappaB at Ser 536 and Ser 468 , and NADPH oxidase are involved in TNF-alpha stimulated IL-6 synthesis . Positive_regulation IL6 TNF 20226180 2243968 We compare and contrast the ability of the p38 MAPK inhibitors to repress *induced* [interleukin 6 (IL-6)] and interleukin 8 (IL-8) mRNA expression and protein secretion from airway smooth muscle cells . Positive_regulation IL6 TNF 20234193 2360240 In vitro , PND-1186 reduced *triggered* [interleukin-6] cytokine expression , indicating that FAK inhibition may impact tumor progression via effects on both tumor and stromal cells . Positive_regulation IL6 TNF 2026875 157479 In addition , it was shown that IL-6 production by in vitro activated B cells was partially blocked by an anti-TNF-alpha antibody suggesting that *regulates* [IL-6] production in normal B cells via an autocrine pathway . Positive_regulation IL6 TNF 2027138 157485 [IL-6] production was *induced* by IL-1 alpha and . Positive_regulation IL6 TNF 20301193 2238028 Although IL-27 did not alter the basal IL-6 secretion from bronchial epithelial cells , it could significantly augment *induced* [IL-6] release . Positive_regulation IL6 TNF 20347984 2281912 In human macrophages THP-1 , treatment with different cytokines was able to stimulate by about 3-folds the release of IL-6 and Manidipine 1 microM showed a 25 % inhibition on *induced* [IL-6] secretion . Positive_regulation IL6 TNF 20372827 2238923 Synergistic effect of vasoactive intestinal peptides on *induced* [IL-6] synthesis in osteoblasts : amplification of p44/p42 MAP kinase activation . Positive_regulation IL6 TNF 20372827 2238924 We previously showed that *stimulates* synthesis of [interleukin-6 (IL-6)] , a potent bone resorptive agent , via p44/p42 mitogen activated protein (MAP) kinase and phosphatidylinositol 3-kinase/Akt in osteoblast-like MC3T3-E1 cells . Positive_regulation IL6 TNF 20372827 2238925 In the present study , we investigated the effect of vasoactive intestinal peptide (VIP) on *induced* [IL-6] synthesis in these cells . Positive_regulation IL6 TNF 20372827 2238927 VIP , which by itself slightly stimulated IL-6 synthesis , synergistically enhanced the *induced* [IL-6] synthesis in MC3T3-E1 cells . Positive_regulation IL6 TNF 20372827 2238929 The synergistic effect of VIP on the *induced* [IL-6] synthesis was concentration dependent in the range between 1 and 70 nM . Positive_regulation IL6 TNF 20372827 2238932 Forskolin , a direct activator of adenylyl cyclase , or 8-bromoadenosine-3',5'-cyclic monophosphate ( 8bromo-cAMP ) , a plasma membrane-permeable cAMP analogue , markedly enhanced the *induced* [IL-6] synthesis as well as VIP . Positive_regulation IL6 TNF 20372827 2238940 PD98059 , a specific inhibitor of MEK1/2 , significantly suppressed the enhancement of *induced* [IL-6] synthesis by VIP . Positive_regulation IL6 TNF 20372827 2238941 These results strongly suggest that VIP synergistically enhances *stimulated* [IL-6] synthesis via up-regulating p44/p42 MAP kinase through the adenylyl cyclase-cAMP system in osteoblasts . Positive_regulation IL6 TNF 20388003 2245287 Endotoxin , , and dust *stimulated* the release of [IL-6] and IL-8 in a time dependent manner . Positive_regulation IL6 TNF 20435921 2288106 TBP and TNF-SHARC dose-dependently inhibited *induced* secretion of [interleukin (IL)-6] , IL-8 , granulocyte macrophage-colony stimulating factor , and monocyte chemoattractant protein-1 in immortalized human endometriotic cells . Positive_regulation IL6 TNF 20505949 2424456 The release of ENA-78 , IL-8 and [IL-6] by the isolated and monolayer cultured stromal cell fraction in the *presence* of IL-1ß ( 0.08 to 50 ng/mL ) , , and interferon-? ( both 20 to 500 ng/mL ) was determined . Positive_regulation IL6 TNF 20506163 2289316 In this study , we show that HK-2 cells express endothelial protein C receptor (EPCR) and that the occupancy of this receptor by protein C switches the signaling specificity of thrombin so that the activation of PAR-1 by thrombin inhibits the *mediated* synthesis of [IL-6] and IL-8 and down-regulates the TGF-beta mediated expression of ECM proteins . Positive_regulation IL6 TNF 20515643 2327484 In differentiating 3T3-F442A adipocytes , fucoxanthinol , which is a fucoxanthin metabolite found in WAT , attenuated *induced* MCP-1 and [IL-6] mRNA overexpression and protein secretion into the culture medium . Positive_regulation IL6 TNF 20557886 2308778 Q-real-time PCR and protein array approaches confirmed that *induced* ICAM-1 , VCAM-1 and ELAM-1 as well as MCP-1 and [IL-6] induction was affected upon 3beta-Adiol pre-incubation . Positive_regulation IL6 TNF 20609399 2321711 In contrast , dual inhibition with both p38/JNK inhibitors almost completely abolished *induced* [IL-6] production from these cells . Positive_regulation IL6 TNF 20609399 2321712 Ablation of ASK1 expression in RASF using siRNA for ASK1 resulted in inhibition of *induced* [IL-6] and PGE ( 2 ) production . Positive_regulation IL6 TNF 20665032 2531491 Nicotine inhibits *induced* [IL-6] and IL-8 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis . Positive_regulation IL6 TNF 20665032 2531493 Nicotine at concentrations of 0.1-10 µM dose reduced the protein and mRNA expression of [IL-6] and IL-8 *induced* by . Positive_regulation IL6 TNF 20673622 2305321 ( ii ) AREG gene silencing has a potent inhibitory effect on *induced* [IL-6] and IL-8 secretion in healthy SGEC treated with anti-Ro/SSA Abs . Positive_regulation IL6 TNF 20673622 2305323 These findings indicate that TACE mediated AREG shedding plays a critical role in *induced* [IL-6] and IL-8 secretion by the human healthy salivary gland epithelial cells , suggesting that this may be one of the possible intracellular mechanisms involved in the salivary glands inflammatory response in Sjögren 's syndrome . Positive_regulation IL6 TNF 20704555 2357001 Moreover RHAs secrete IL-1ß and , only after the Aß1-42 treatment , *promotes* RCEC release of IL-1ß , [IL-6] and TNF-a . Positive_regulation IL6 TNF 20732383 2363465 Wnt3a regulates *stimulated* [interleukin-6] release in osteoblasts . Positive_regulation IL6 TNF 20732383 2363468 In the present study , we investigated the effect of Wnt3a on *stimulated* [IL-6] synthesis in these cells . Positive_regulation IL6 TNF 20732383 2363471 Wnt3a , which alone did not affect the IL-6 levels , significantly suppressed the *stimulated* [IL-6] release . Positive_regulation IL6 TNF 20732383 2363472 Lithium Chloride ( LiCl ) , which is an inhibitor of GSK3ß , markedly reduced the *stimulated* [IL-6] release , similar to the results with Wnt3a . Positive_regulation IL6 TNF 20732383 2363476 Lactacystin , a proteasome inhibitor , and bafilomycin A1 , a lysosomal protease inhibitor , significantly restored the suppressive effect of Wnt3a on *stimulated* [IL-6] release . Positive_regulation IL6 TNF 20943792 2347875 Quercetin , and to a lesser extent trans-RSV , attenuated the *induced* expression of inflammatory genes such as [interleukin (IL)-6] , IL-1ß , IL-8 , and monocyte chemoattractant protein-1 ( MCP-1 ) and the secretion of IL-6 , IL-8 , and MCP-1 . Positive_regulation IL6 TNF 20953204 2343680 *induced* [IL-6] production was measured by ELISA and effects on related signaling pathways were investigated by immunoblot analysis . Positive_regulation IL6 TNF 21036166 2365495 Intracellular transfer of an inhibitory anti-Cx32 monoclonal antibody significantly enhanced *induced* monocyte chemotactic protein (MCP)-1 and [IL-6] expression , but overexpression of Cx32 abrogated TNF-a induced MCP-1 and IL-6 expression . Positive_regulation IL6 TNF 2104896 126860 The inflammatory cytokines IL-1 , and , to a lesser extent , and IFN-gamma *increased* [IL-6] production . Positive_regulation IL6 TNF 2113076 135553 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL6 TNF 2113431 135576 Thus even though production precedes that of IL-1 and IL-6 , and *stimulates* [IL-6] production in fibroblasts , there is no evidence that TNF-alpha acts to amplify the production of IL-6 or IL-1 by murine macrophage cell lines . Positive_regulation IL6 TNF 21136335 2355908 PDGF-BB and *induced* [IL-6] secretion by lung fibroblasts and this was inhibited by DMF in a dose dependent manner . Positive_regulation IL6 TNF 21136335 2355913 Our data suggest that DMF down-regulates *induced* [IL-6] secretion and proliferation by inhibiting NF-?B and AP-1 activity , indicating its potential beneficial use for the treatment of inflammatory lung diseases . Positive_regulation IL6 TNF 21186817 2378855 The results showed that p-coumaric acid , quercetin , and resveratrol have greater inhibition ( p < 0.05 ) of a *induced* increase in the production of [interleukin-6 (IL-6)] among 21 tested polyphenolic compounds . Positive_regulation IL6 TNF 21190512 2396792 We have shown that up-regulates CUNS and *increases* [interleukin 6 expression (IL-6)] within hours of administration . Positive_regulation IL6 TNF 21191629 2425303 *induces* expression and release of [interleukin-6] by human urothelial cells . Positive_regulation IL6 TNF 21191629 2425306 The effects of selective blockers of MAPK pathways on *induced* [IL-6] expression and release were determined . Positive_regulation IL6 TNF 21191629 2425307 *increased* [IL-6] mRNA expression and stimulated release of IL-6 in a concentration- and time dependent manner . Positive_regulation IL6 TNF 21191629 2425310 *induced* phosphorylation of ERK1/2 and JNK , and TNF-a induced [IL-6] expression and release were inhibited by selective ERK1/2 and JNK blockers . Positive_regulation IL6 TNF 21191629 2425314 These results demonstrate that TNF-a increases expression and release of [IL-6] by HUCs and that the effects of are *mediated* by TNFR1 . Positive_regulation IL6 TNF 21191629 2425316 Also , the ERK1/2 and JNK pathways are involved in *induced* expression and release of [IL-6] in HUCs and may represent therapeutic targets in inflammatory urinary tract diseases . Positive_regulation IL6 TNF 2121800 143906 IL-6 induction by LPS/Ca2+ ionophore is more sensitive to the suppressive effects of dexamethasone than is [IL-6] *induction* by beta . Positive_regulation IL6 TNF 21251215 2509660 Nox2 and Nox4 siRNA were used to determine whether or not Nox2 and Nox4 mediated induced ROS and *upregulation* of IL-1ß and [IL-6] in adult human cardiomyocytes . Positive_regulation IL6 TNF 21251215 2509666 Nox2 and Nox4 siRNA significantly attenuated *induced* ROS and upregulation of IL-1ß and [IL-6] in cardiomyocytes . Positive_regulation IL6 TNF 21290470 2359941 Moreover , expression of E-selectin , [IL-6] , and IL-8 was *induced* most efficiently by IL-1ß , while LPS and had less effect , whereas we did not find such a difference in ICAM-1 and MCP-1 expression . Positive_regulation IL6 TNF 21294864 2493977 Exogenous addition of IL-17 dramatically *enhanced* the spontaneous production of [IL-6] and prostaglandin E2 ( PGE2 ) by the ST-derived inflammatory cells , while it had no effect on the production of and macrophage colony stimulating factor ( M-CSF ) . Positive_regulation IL6 TNF 21300032 2403522 Combined ß-adrenergic and triggering *induces* synergistic [IL-6] expression in 1321N1 cells via a transcriptional enhancer mechanism . Positive_regulation IL6 TNF 21349589 2399584 Stimulation of endothelial monolayers with *resulted* in significant increase of toll-like receptor 4 , [interleukin-6] and -8 , and intercellular adhesion molecule-1 and vascular cellular adhesion molecule-1 gene expression in a time dependent manner . Positive_regulation IL6 TNF 21474440 2433934 Glucocorticoid independent repression of *stimulated* [interleukin (IL)-6] expression by the glucocorticoid receptor : a potential mechanism for protection against an excessive inflammatory response . Positive_regulation IL6 TNF 21492875 2438890 Enzyme linked immunoassay ( ELISA ) was used to evaluate [interleukin-6 (IL-6)] expression in *response* to IL-1ß and stimulation in vitro to validate MK2 kinase inhibition . Positive_regulation IL6 TNF 21595635 2441544 Pre-eclampsia was associated with increased between the 26th and 29th week ( p=0.0421 ) and *increased* [IL-6] after the 36th week ( p=0.0044 ) . Positive_regulation IL6 TNF 21682792 2524004 Release of [IL-6] and IL-23 was *enhanced* less than twofold by the addition of AF while production was unchanged . Positive_regulation IL6 TNF 21722069 2515911 IFN-? and *induce* a different modulation of [interleukin-6] in systemic sclerosis fibroblasts compared to healthy controls . Positive_regulation IL6 TNF 21745554 2471929 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL6 TNF 21806874 2462485 [ Signal transduction pathway for *induced* [IL-6] release from mast cells ] . Positive_regulation IL6 TNF 21806874 2462488 Pretreatment of PD98059 or U0126 inhibited *induced* [IL-6] release and ERK phosphorylation in P815 cells ( P < 0.05 ) , whereas pretreatment of SB203580 or AG490 hardly affect IL-6 release , with little effect on phosphorylation of p38 and STAT3 respectively . Positive_regulation IL6 TNF 21810609 2467809 Using small interfering RNA mediated KAP1 knockdown , we found that endogenous KAP1 negatively regulated *induced* [IL-6] production in HeLa cells . Positive_regulation IL6 TNF 21811758 2472789 Role of HSP27 in *stimulated* [interleukin-6] synthesis in osteoblasts . Positive_regulation IL6 TNF 21811758 2472793 In the present study , we investigated the role of HSP27 in *stimulated* [interleukin-6 (IL-6)] synthesis in MC3T3-E1 cells . Positive_regulation IL6 TNF 21811758 2472796 Therefore , these results strongly suggest that HSP27 enhances *stimulated* [IL-6] synthesis , and that the phosphorylation status of HSP27 is related to IL-6 synthesis in osteoblasts . Positive_regulation IL6 TNF 21862654 2486522 Among inflammatory cytokine related genes , blockade *reduced* expression of interleukin (IL)-1 receptor type 2 , interferon-? receptors , [IL6] , IL6 receptor , gp130 , and IL17 receptors . Positive_regulation IL6 TNF 21895661 2532521 The results obtained in the present study show that P. gingivalis extract induces TNF-a and [IL-6] in an in vitro liver model and that macrophage derived *mediates* the induction of TNF-a in hepatocytes . Positive_regulation IL6 TNF 2192263 136199 [Interleukin-6] *induction* by and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence . Positive_regulation IL6 TNF 2192263 136226 On the basis of these and other experiments , we conclude that and IL-1 apparently *activate* [IL-6] gene expression by closely related mechanisms involving activation of a NF-kappa B-like factor , whereas the pathway of IL-6 induction by forskolin is , in part , different . Positive_regulation IL6 TNF 21995333 2507618 Moreover induction of [IL-6] and IL-8 was primarily *regulated* by MC-derived . Positive_regulation IL6 TNF 2203522 140653 while [IL-6] could be *induced* by both IL-1 beta and . Positive_regulation IL6 TNF 22055894 2527914 Inhibition of *induced* [IL-6] by the TWEAK-Fn14 interaction in rheumatoid arthritis fibroblast like synoviocytes . Positive_regulation IL6 TNF 22190977 2531310 Notch signaling mediates *induced* [IL-6] production in cultured fibroblast-like synoviocytes from rheumatoid arthritis . Positive_regulation IL6 TNF 22190977 2531318 stimulation also *induced* [IL-6] secretion in OA FLSs ; Positive_regulation IL6 TNF 22207455 2585931 Vasoactive intestinal peptide enhances *induced* [IL-6] and IL-8 synthesis in human proximal renal tubular epithelial cells by NF-?B dependent mechanism . Positive_regulation IL6 TNF 22207455 2585937 We report here that *increased* [IL-6] and IL-8 production , and that these effects were potentiated by VIP at 10 nM in HK-2 cells . Positive_regulation IL6 TNF 22207455 2585941 These results strongly suggest that VIP synergistically enhances *stimulated* [IL-6] and IL-8 synthesis via activating the NF-?B pathway in HK-2 cells . Positive_regulation IL6 TNF 22226857 2559200 Moreover , we found that DEM pretreatment enhanced the production of [IL-6] *induced* by . Positive_regulation IL6 TNF 22226857 2559201 Knockdown of ASMase attenuated the enhancement of *dependent* [IL-6] production . Positive_regulation IL6 TNF 22226857 2559203 On the other hand , enhancement of *induced* [IL-6] production was observed in ASMase overexpressing cells without DEM. Fractionation of the lipid raft revealed that the TNF receptor 1 (TNFR1) was migrated into the lipid raft in DEM treated cells or ASMase overexpressing cells . Positive_regulation IL6 TNF 22226857 2559204 The *induced* [IL-6] expression required the clustering of TNFR1 since IL-6 expression were decreased by the destruction of the lipid raft with filipin . Positive_regulation IL6 TNF 22226857 2559205 These results demonstrated a new role for ASMase in the acceleration of the production of *induced* [IL-6] as a pro-inflammatory cytokine and indicated that electrophiles could potentiate inflammation response by up-regulating of ASMase expression following formation of lipid rafts . Positive_regulation IL6 TNF 22265273 2559735 For groups categorized by the extent and severity of carotid artery plaques , Th17 cell frequencies , common carotid artery intima-media thickness ( CCA-IMT ) , and Crouse scores were significantly increased in higher level groups ( Levels 3 and 4 ) than in lower level groups ( Levels 1 and 2 ) , and plasma concentrations of IL-17 , [IL-6] , and *increased* with increased levels of plaque severity . Positive_regulation IL6 TNF 2226778 144488 The *induction* of [IL-6] transcripts by and LT was not inhibited by the isoquinoline sulfonamide derivative H7 . Positive_regulation IL6 TNF 2226778 144489 Similarly , depletion of protein kinase C ( PKC ) by 12-O-tetradecanoyl-phorbol 13-acetate ( TPA ) did not change the ability of and LT to *induce* [IL-6] transcripts , demonstrating that stimulation by these agents may not be mediated by activation of PKC . Positive_regulation IL6 TNF 22293775 2551794 ?-Tocotrienol attenuates *induced* changes in secretion and gene expression of MCP-1 , [IL-6] and adiponectin in 3T3-L1 adipocytes . Positive_regulation IL6 TNF 22293775 2551797 ?-tocotrienol effectively improved the *induced* adverse changes in MCP-1 , [IL-6] and adiponectin secretion , and in MCP-1 , IL-6 , adiponectin and PPAR? mRNA expression . Positive_regulation IL6 TNF 22391344 2612498 Circulating levels of endotoxin , [interleukin (IL)-6] , and *increase* with intestinal bacterial overgrowth and translocation , and are believed to be involved in the pathogenesis of hyperdynamic circulatory syndrome and functional renal failure in patients with advanced cirrhosis . Positive_regulation IL6 TNF 22396222 2593219 In addition to the interference of artemisinic acid with adipogenesis , artemisinic acid significantly attenuated *induced* secretion of [interleukin-6] by undifferentiated hAMSCs , thus influencing insulin resistance and the inflammatory state characterizing obesity . Positive_regulation IL6 TNF 22426177 2588154 HuR post-transcriptionally regulates *induced* [IL-6] expression in human pulmonary microvascular endothelial cells mainly via tristetraprolin . Positive_regulation IL6 TNF 22426177 2588157 Our previous study showed that HuR upregulated *induced* [interleukin-6 (IL-6)] expression by stabilizing its mRNA in human pulmonary microvascular endothelial cells ( HPMECs ) . Positive_regulation IL6 TNF 22426177 2588159 Considering IL-6 mRNA has AREs , we decided to examine whether TTP was also involved in the regulation of *induced* [IL-6] expression in HPMECs and whether HuR and TTP influenced each other at protein and mRNA level . Positive_regulation IL6 TNF 22427564 2588226 significantly *increased* the expression of [IL-6] , IL-8 , and MCP-1 in ARPE-19 cells at both the protein and mRNA levels . Positive_regulation IL6 TNF 22427566 2588231 *increased* the expression and secretion of [IL-6] and Ccl2 in ARPE-19 cells . Positive_regulation IL6 TNF 22427566 2588233 In contrast , GPR109A ligands failed to suppress *induced* expression and secretion of [IL-6] and Ccl2 in primary RPE cells from Gpr109a ( -/- ) mice , confirming that the observed anti-inflammatory effects were mediated specifically by Gpr109a . Positive_regulation IL6 TNF 22498762 2601796 Curcumin also inhibited the *induced* production of [IL-6/IL-8] in HaCaT cells . Positive_regulation IL6 TNF 22637477 2625552 With cultured vascular smooth muscle cell , angiotensin II , arachidonic acid , and markedly *induce* increased expression of [IL-6] and TNF-a mRNAs , all of which were suppressed by inhibiting iPLA(2)ß activity or expression with bromoenol lactone , antisense oligonucleotides , and genetic deletion , respectively . Positive_regulation IL6 TNF 2265482 147236 Several studies have shown that the cytokine [interleukin-6 (IL-6)] is produced in *response* to in vitro . Positive_regulation IL6 TNF 2265482 147238 These findings suggest that the very high levels of [IL-6] found in certain disease states are not purely the *result* of circulating . Positive_regulation IL6 TNF 22777765 2715526 Silencing constitutive AnxA1 expression in NLF using small interfering RNA ( siRNA ) was associated with moderate but significant increases in *induced* proliferation and [interleukin (IL)-6] production , accompanied by reduction of ERK and NF-?B activity . Positive_regulation IL6 TNF 2290028 149506 The secretion of [IL-6] could also be *induced* by interleukin (IL)-1 beta and ( TNF-alpha ) . Positive_regulation IL6 TNF 22922824 2672501 [IL-6-synthesis] was *augmented* by trauma , and combined treatment . Positive_regulation IL6 TNF 22954523 2688250 Pterostilbene treatment inhibited *induced* secretion of lipase ( P < 0.01 and P < 0.001 ) , IL-1ß ( P < 0.05 ) , and [IL-6] ( P < 0.05 and P < 0.01 ) . Positive_regulation IL6 TNF 2297793 127608 The protective effect of and IL-1 alpha is not *mediated* by the induction of IFN-beta [2/IL-6] . Positive_regulation IL6 TNF 23028840 2680699 Furthermore , prior remifentanil incubation prevented *induced* [IL-6] release of HepG2 cells , and attenuated fragmentation of pro-caspase-3 into cleaved active caspase 3 ( an early marker of apoptosis ) . Positive_regulation IL6 TNF 23046548 2706514 Unopsonized IE *induced* secretion of [IL-6] ( median= 622 pg/ml [ IQR=1,250-240 ] , n=9 ) but no IL-1ß or TNF , whereas PPS opsonized IE induced secretion of IL-1ß ( 18.6 pg/mL [ 34.2-14.4 ] ) and ( 113 pg/ml [ 421-17.0 ] ) and increased IL-6 secretion ( 2,195 pg/ml [ 4,658-1,095 ] ) . Positive_regulation IL6 TNF 23132229 2696479 Exogenous H ( 2 ) S inhibited the *mediated* upregulation of NO , [IL-6] and IL-8 in a dose dependent manner . Positive_regulation IL6 TNF 23133751 2696604 In RA , primarily *contributes* to the arthritis effector phase and [IL-6] contributes to the arthritis priming phase . Positive_regulation IL6 TNF 23159491 2729677 Finally , we demonstrate that the transmembrane forms of wild-type and palmitoylation-defective interact differently with TNFR1 and *regulate* NF?B activity , Erk1/2 phosphorylation and [interleukin-6] synthesis differently , strongly suggesting that palmitoylation of TNF is involved in the regulation of TNFR1 signalling . Positive_regulation IL6 TNF 23208413 2705387 Gene expression analyses showed that and IL-1ß *stimulate* the adipocyte expression of TNF-a , IL-1ß and [IL-6] . Positive_regulation IL6 TNF 23211566 2752105 Unfractionated heparin significantly suppressed the *induced* and NF-?B mediated secretion and expression of [IL-8 and -6] as well as other molecules in decidualized and undifferentiated human ESCs . Positive_regulation IL6 TNF 23246159 2780527 Despite necessary for IL-6 , NF-?B activation by or other cytokines is not *sufficient* for [IL-6] induction with exception of LPS . Positive_regulation IL6 TNF 23261764 2737327 Furthermore , inhibition of synthesis by intraperitoneal thalidomide *prevented* both mechanical allodynia and the up-regulation of [IL-6] in DRGs following L5-VRT . Positive_regulation IL6 TNF 23275623 2741922 We hypothesized that Trek-1 regulates *induced* [IL-6] release via NF-?B- , p38- , and PKC dependent pathways . Positive_regulation IL6 TNF 23281820 2775379 Rapamycin enhances *induced* secretion of [IL-6] and IL-8 through suppressing PDCD4 degradation in orbital fibroblasts . Positive_regulation IL6 TNF 23281820 2775381 To investigate the effects of rapamycin on the *induced* secretion of [interleukin-6 (IL-6)] and IL-8 in orbital fibroblasts and its possible mechanism . Positive_regulation IL6 TNF 23281820 2775383 Rapamycin significantly enhanced *induced* [IL-6] and IL-8 secretion from orbital fibroblasts . Positive_regulation IL6 TNF 23281820 2775385 Down-regulation of PDCD4 by PDCD4 siRNA transfection reduced *induced* [IL-6] and IL-8 secretion from orbital fibroblasts . Positive_regulation IL6 TNF 23281820 2775390 Rapamycin enhances the *induced* secretion of [IL-6] and IL-8 by suppressing PDCD4 degradation in orbital fibroblasts . Positive_regulation IL6 TNF 23285694 2711896 Effect of Gly-Gly-His , Gly-His-Lys and their copper complexes on *dependent* [IL-6] secretion in normal human dermal fibroblasts . Positive_regulation IL6 TNF 23285694 2711897 GGH , GHK , CuCl2 and their copper complexes decreased *dependent* [IL-6] secretion in fibroblasts . Positive_regulation IL6 TNF 23285697 2711898 After 24 h incubation *dependent* [IL-6] secretion was determined with ELISA kit ( RandD Systems ) . Positive_regulation IL6 TNF 23285697 2711900 It was shown that SMF inhibited *dependent* [IL-6] secretion . Positive_regulation IL6 TNF 23295714 2752460 Sevoflurane suppressed *induced* [IL-6] , IL-8 , and MCP-1 gene expression and the production of IL-6 and IL-8 in SAEC under anoxia/reoxygenation conditions . Positive_regulation IL6 TNF 23300158 2843255 Ribavirin decreased the virus load and dose-dependently inhibited the accumulation of RANTES messenger RNA in Andes-virus ( ANDV ) -infected human endothelial cells , but failed to suppress *induced* activation of RANTES and [interleukin-6] in ANDV inoculated cultures . Positive_regulation IL6 TNF 2335239 132670 We show that the capacity of and LT to *induce* [IL-6] mRNA accumulation increases as monocytic differentiation proceeds with TNF alpha being more potent than LT , suggesting that alternate pathways may be used by differentiating cells to control expression of IL-6 . Positive_regulation IL6 TNF 2335239 132671 In these cells *enhanced* steady state levels of [IL-6] transcripts due to mRNA stabilization , whereas LT shortened IL-6 mRNA half-life , most likely due to induction of a RNA destabilizer since LT-mediated downregulation of levels of IL-6 mRNA in monocytes could be prevented by inhibition of protein synthesis . Positive_regulation IL6 TNF 23365744 2712925 stimulation *caused* similar IL-1ß , [IL-6] , and IL-8 release in all groups . Positive_regulation IL6 TNF 23396138 2775965 *mediated* [IL-6] induction in MCF-7 cells was counteracted by silencing aryl hydrocarbon receptor (AhR) , known to mediates most of PAH effects . Positive_regulation IL6 TNF 2346722 134850 This study investigates the capacity of interleukin-1 alpha (IL-1 alpha) , interleukin-1 beta (IL-1 beta) and to *induce* [interleukin-6 (IL-6)] production in freshly isolated myeloma cells ( MC ) and bone marrow derived stromal cells (MSC) . Positive_regulation IL6 TNF 2346722 134852 Recombinant human ( rh ) IL-1 alpha , IL-1 beta and *augmented* production of [IL-6] in human MC . IL-6 was determined on a factor dependent Cess cell line . Positive_regulation IL6 TNF 23552726 2789060 Recombinant AAT-Fc protein was tested for antiinflammatory function and AAT-Fc sufficiently suppressed *induced* [interleukin (IL)-6] in human peripheral blood mononuclear cells ( PBMCs ) and inhibited cytokine induced TNFa by different cytokines in mouse macrophage Raw 264.7 cells . Positive_regulation IL6 TNF 2358670 136520 IL-1 and synergistically *stimulate* fibroblast [IL-6] production and stabilize IL-6 messenger RNA . Positive_regulation IL6 TNF 23609474 2838194 These results provide evidence that attenuation of the iNOS pathway and suppression of the inflammatory response *mediated* by , and [IL-6] could be implicated in the antitumor effect of NSEE . Positive_regulation IL6 TNF 2364381 136637 These data suggest that [interleukin 6] , but not platelet activating factor , prostaglandins , or catecholamines , could potentially *mediate* the lipogenic effects of . Positive_regulation IL6 TNF 23659985 2819243 Finally , metformin dose-dependently reduced *induced* [IL-6] and I?Ba levels in cultured placental JAR cells . Positive_regulation IL6 TNF 23659985 2819244 Similarly , metformin treatment of a placental cell line suppressed *induced* [IL-6] levels by NF?B inhibitor . Positive_regulation IL6 TNF 23675187 2367227 We have studied the expression of [interleukin-6] *induced* by interleukin-1 ß and a in the osteoblast-like cell line MG-63 , derived from a human osteosarcoma . Positive_regulation IL6 TNF 2370931 138356 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL6 TNF 23712050 2838439 Remnant livers of Ldlr ( - ) ( / ) ( - ) showed a time shifted expression of [interleukin-6 (IL6)] and a defective *activation* of and hepatocyte growth factor (HGF) expression in early phases of liver regeneration . Positive_regulation IL6 TNF 23740089 2878216 The pro-inflammatory cytokine [IL-6] was *up-regulated* more than 1.6-fold by 0.1 ng/mL . Positive_regulation IL6 TNF 23760613 2887306 In addition , 6-MSITC reduced *induced* [interleukin-6] and monocyte chemoattractant protein-1 expression . Positive_regulation IL6 TNF 23799152 2802843 Knocking down WWP1 enhanced the TNF-a and IL-6 production induced by LPS , and over-expression of WWP1 inhibited the TNF-a and [IL-6] production *induced* by LPS , but not by . Positive_regulation IL6 TNF 23810685 2834476 THC *inhibited* the production of TNF-a and [IL-6] by down regulating LPS induced IL-6 and mRNA expression . Positive_regulation IL6 TNF 23817415 2815763 In this study , we showed that endogenous Y14 positively regulated *induced* [IL-6] expression in HeLa cells . Positive_regulation IL6 TNF 23817415 2815769 However , our manipulation of Y14 expression indicated that it is involved in *induced* [IL-6] expression via both STAT3 dependent and -independent mechanisms . Positive_regulation IL6 TNF 23817415 2815772 Therefore , Y14 positively regulates signals for *induced* [IL-6] production at multiple steps beyond an exon junction complex protein . Positive_regulation IL6 TNF 23835341 2865819 Direct effects of on local fuel metabolism and cytokine levels in the placebo controlled , bilaterally infused human leg : increased insulin sensitivity , increased net protein breakdown , and *increased* [IL-6] release . Positive_regulation IL6 TNF 23862224 2817454 + CAPE *induced* statistically lower expressions of [IL-6] and p-STAT3 than TNF-alpha alone ( P < 0.05 ) . Positive_regulation IL6 TNF 23862224 2817455 CAPE can inhibit [IL-6] secretion *induced* by in PC-3 cells and thus suppress STAT3 translocation . Positive_regulation IL6 TNF 23967134 2832632 E3330 treatment prevented the functional activation of NF-?B via the alteration of APE1 subcellular trafficking and reduced [IL-6] and IL-8 expression *induced* by and FAs accumulation through blockage of the redox mediated activation of NF-?B . Positive_regulation IL6 TNF 2405250 128049 We demonstrate that a common IL-6 promoter element , termed inflammatory lymphokine-responsive element ( ILRE ) , is important for *induction* of [IL-6] gene expression by IL-1 and despite possible differences in the mechanisms of action of these lymphokines . Positive_regulation IL6 TNF 2405250 128051 In addition , mutations of the ILRE sequence which impair the binding of this nuclear factor abolished the *induction* of [IL-6] gene expression by IL-1 and in vivo . Positive_regulation IL6 TNF 2405250 128053 These results indicate that a nuclear factor indistinguishable from NF-kappa B is involved in the transcriptional *activation* of the [IL-6] gene by IL-1 and . Positive_regulation IL6 TNF 2407539 130398 [IL 6] and secretion *increased* from day 6 to day 20 whereas IL 1 secretion increased until day 13 and decreased on day 20 . Positive_regulation IL6 TNF 24098382 2852219 Further , systemic ( R ) -DOI also prevents the *induced* increase of circulating [IL-6] . Positive_regulation IL6 TNF 24129565 2875071 Chromatin immunoprecipitation ( ChIP ) assays demonstrated decreased NF-?B binding to the promoters of [IL-6] , IL-8 , and I?Ba in *response* to with TGF-ß1 pretreatment . Positive_regulation IL6 TNF 24238522 2868879 Mitogen activated protein kinase activated protein kinase 2 regulates *induced* [interleukin-6] expression via human antigen R . Positive_regulation IL6 TNF 24238522 2868893 In this study , we investigated whether mitogen activated protein kinase (MAPK) activated protein kinase 2 ( MK2 ) and HuR participate in the *induced* expression of [interleukin-6 (IL-6)] . Positive_regulation IL6 TNF 24238522 2868894 MK2 regulates the *induced* expression of [IL-6] by influencing the cytoplasmic levels of HuR . Positive_regulation IL6 TNF 24244348 2869108 We demonstrate that induced activation of NF-?B is *sufficient* to induce [IL-6] expression , activate STAT3 , and elevate STAT3 target gene expression in GBM cell lines and human GBM xenografts in vitro . Positive_regulation IL6 TNF 24290899 2904686 Elevated [IL-6] levels and neutrophil counts also reduced the risk of abnormal FEV1 but in contrast to CRS , increased did not *increase* the risk of abnormal FEV1 . Positive_regulation IL6 TNF 2452159 91103 Synthesis of [IL-6] is *stimulated* by interleukin 1 (IL-1) , , or platelet derived growth factor . Positive_regulation IL6 TNF 2452159 91105 IL-1 and too *increased* [IL-6] mRNA levels by a protein kinase C-independent mechanism . Positive_regulation IL6 TNF 2452159 91107 Our results suggest a role for the cAMP dependent pathway ( s ) in [IL-6] gene *activation* by and IL-1 . Positive_regulation IL6 TNF 24583856 2920145 The CA treatment also significantly reduced the mRNA and protein levels of tumor necrosis factor alpha ( TNF-a ) , interleukin-6 (IL-6) and IL-1ß at the application site , and the TNF-a production , the *induced* [IL-6] and IL-1ß production , and TNF-a induced nuclear factor-kappa B ( NF-?B ) activation in human keratinocytes in vitro . Positive_regulation IL6 TNF 24620386 2886418 The preoperative levels of tumor necrosis factor-a (TNF -a) and interleukin-6 OL-6 ) were both less than 1.0 ng/L , and the postoperative levels of showed no significant change , and [IL-6] was *increased* to 485.10 ( 104.00-837.50 ) ng/L and 193.26 ( 95.10-385.20 ) ng/L in control and Xuebijing groups respectively ( P < 0.01 ) . Positive_regulation IL6 TNF 24699803 2938771 In ARPE-19 cells , *induced* proinflammatory gene expression of interleukin (IL)-1ß , [IL-6] , and monocyte chemotactic protein-1 was decreased by 35.0 % , 68.8 % , and 62.5 % , respectively , with MGP pretreatment , which was primarily due to the diminished mitogen activated protein kinase activation and subsequent reduction of nuclear factor ?-B activation . Positive_regulation IL6 TNF 2496589 109664 Further experiments , such as the study of [IL-6] *induction* by in mice , allowed us to distinguish two types of TNF effects : those that can equally well be exerted by human rTNF and by murine rTNF ( type I effects ) and those that can only be exerted by murine rTNF ( type II effects ) . Positive_regulation IL6 TNF 25066751 2953738 While significant alterations were observed in all cytokines during the monitoring period , [IL-6] levels remained consistently higher in fatal cases and levels *increased* in both in fatal and non-fatal CCHF cases . Positive_regulation IL6 TNF 2523936 109927 IL-1 and *induced* concentration related increases in the synthesis of factor B , C3 , and IFN-beta [2/IL-6] in human skin fibroblasts . Positive_regulation IL6 TNF 2523936 109934 An autocrine action of TNF through IL-1 is possible for *induced* synthesis of IFN-beta [2/IL-6] , but the effects of TNF on synthesis of factor B , C3 , and factor H indicated that TNF has effects on fibroblasts separate from IL-1 . Positive_regulation IL6 TNF 2788520 118172 LPS , lipid A , and *increased* [IL6] release modestly ( 5 to 20-fold ) , while recombinant IL1s ( rIL1s ) stimulated this process 100 to 400-fold . Positive_regulation IL6 TNF 2805453 121215 Endotoxin , and interleukin 1 *induce* [interleukin 6] production in vivo . Positive_regulation IL6 TNF 2805453 121247 The ability of Escherichia coli derived lipopolysaccharide (LPS) , recombinant ( r ) interleukin 1-beta ( rIL-1 beta ) , and r murine ( rMuTNF-alpha ) to *induce* [interleukin 6 (IL-6)] production in vivo was investigated . Positive_regulation IL6 TNF 2805453 121250 These data demonstrate the abilities of IL-1 beta and to *induce* [IL-6] production in vivo and indicate that LPS induction of IL-6 may be mediated , at least partially , through TNF-alpha action . Positive_regulation IL6 TNF 2842790 96558 In addition , our data on [IL-6] *induction* by and IL-1 suggest that other , yet unidentified , signal transduction mechanisms contribute to TNF and IL-1 actions on gene expression in human fibroblasts . Positive_regulation IL6 TNF 3011946 59765 Tumor necrosis interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL6 TNF 3486658 59964 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL6 TNF 3486658 60018 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL6 TNF 3486936 60107 ( cachectin ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL6 TNF 3500495 80716 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL6 TNF 3526909 62657 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL6 TNF 7506142 237753 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL6 TNF 7506738 244451 Signal transduction pathways *mediating* astrocyte [IL-6] induction by IL-1 beta and . Positive_regulation IL6 TNF 7506738 244455 We have focused on signal transduction related to the *stimulation* of [IL-6] gene expression by IL-1 beta and . Positive_regulation IL6 TNF 7506738 244457 Our results indicate that stimuli related to protein kinase C ( PKC ) , such as PMA and calcium ionophore A23187 , increase IL-6 expression , whereas pharmacologic inhibitors of PKC inhibit [IL-6] *induction* by IL-1 beta and . Positive_regulation IL6 TNF 7506738 244459 However , inhibition of the cAMP pathway effector , protein kinase A , did not reduce the induction of astrocyte [IL-6] gene expression in *response* to IL-1 beta or , and an ELISA for cAMP detected only very small increases in cAMP synthesis in response to these cytokines . Positive_regulation IL6 TNF 7506738 244463 These data suggest that although cAMP does activate astrocyte IL-6 gene expression , it is the PKC pathway that plays a primary role in the *stimulation* of astrocyte [IL-6] gene expression by IL-1 beta and . Positive_regulation IL6 TNF 7519403 265588 Dexamethasone blocks the *induction* of [IL-6] and IL-8 by IL-1 or . Positive_regulation IL6 TNF 7519403 265593 Both IL-1 and *increased* release of [IL-6] and IL-8 from the cells in a dose dependent manner and dexamethasone inhibited this effect . Positive_regulation IL6 TNF 7536422 297248 [IL-6] could also be *induced* by added to brain cultures . Positive_regulation IL6 TNF 7538333 301273 cA2 inhibited TNF induced mitogenesis and [IL-6] secretion by human fibroblasts , TNF priming of human neutrophils , and the *stimulation* of human umbilical vein endothelial cells by as measured by the expression of E-selectin , ICAM-1 and procoagulant activity . Positive_regulation IL6 TNF 7538467 301321 The difference in the signaling was further evident from our observation that *induced* the expression of [interleukin-6] but anti-Fas did not . Positive_regulation IL6 TNF 7543732 314370 Apigenin also inhibited IL-1 alpha induced prostaglandin synthesis and *induced* [IL-6] and IL-8 production , suggesting that the hydroxyflavones may act as general inhibitors of cytokine induced gene expression . Positive_regulation IL6 TNF 7590883 336353 was found to *enhance* both [IL-6] mRNA expression and protein secretion by the IEC-6 cells . Positive_regulation IL6 TNF 7590883 336354 Although the IEC-6 cells are known to produce TGF-beta , autocrine secreted TGF-beta was found to have no effect on the elevated [IL-6] secretion *induced* by both plus IL-1 beta . Positive_regulation IL6 TNF 7594457 334727 A striking similarity to the requirements for *induced* [IL-6] production , which is mediated by the p55TNF receptor in SV80 cells , was observed . Positive_regulation IL6 TNF 7640431 317853 Interleukin 1 beta and [interleukin 6] could not be *detected* at all , whereas alpha levels were marginally elevated before and after HD with both membranes . Positive_regulation IL6 TNF 7649114 319065 To investigate this hypothesis in a human model , we have examined 12 separate strains of normal human osteoblasts ( HOB ) and 11 separate strains of human bone marrow stromal cells ( HBMSC ) and determined whether ovarian steroids regulate the *induction* of [IL-6] by interleukin-1 beta (IL-1 beta) , or IL-1 + TNF . Positive_regulation IL6 TNF 7686496 222170 [IL-6] production by HEC was significantly increased only in the *presence* of IL-1 beta , , or MECIF activity . Positive_regulation IL6 TNF 7691110 228741 Both IL-1 and *induced* a dose dependent release of [IL-6] ( 5 to 10 ng/10 ( 6 ) cells ) and GM-CSF ( 2 to 3 ng/10 ( 6 ) cells ) by primary epithelial cells from eight normal volunteers . Positive_regulation IL6 TNF 7694480 234309 In particular , we assessed whether dexamethasone was capable of inhibiting the *mediated* secretion of [interleukin-6 (IL-6)] , interleukin-8 (IL-8) , and granulocyte colony stimulating factor ( G-CSF ) by a human bronchial epithelial cell line ( BEAS-2B ) . Positive_regulation IL6 TNF 7737374 305525 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL6 TNF 7743669 306077 LPS , IFN-gamma or *had* no effect on spontaneous [IL-6] production , and neither resulted in the secretion of IL-1 beta or TNF-alpha . Positive_regulation IL6 TNF 7782537 309685 However , most Den-Fb produced more GM-CSF and [IL-6] in the *presence* of . Positive_regulation IL6 TNF 7784700 309915 TNF-alpha , LT , IFN-gamma and [IL-6] mRNAs were *detected* in patients with active multiple sclerosis , whereas , IL-6 , and endothelin-1 mRNA expression was found frequently in patients with HIV encephalitis . Positive_regulation IL6 TNF 7843904 294081 These results demonstrate that both IL-1 alpha and could *induce* keratocytes to produce nanogram levels of [IL-6] but IL-1 alpha was a 30-fold more effective inducer . Positive_regulation IL6 TNF 7851026 294336 also *up-regulated* production of IL-1 alpha , IL-1 beta , IL-1Ra and [IL-6] by monocytes , but the variability in the results of cells cultured from the same individuals on different occasions was greater . Positive_regulation IL6 TNF 7884319 298992 It was found that LPS or [IL-6] alone *induced* moderate levels of CAT expression , whereas IFN-gamma or had no significant effect . Positive_regulation IL6 TNF 7890313 289752 The secretion of [IL-6] was greatly *increased* by ; Positive_regulation IL6 TNF 7926024 273551 We found that : ( i ) *increased* [IL-6] mRNA levels and this increase was inhibited by N-acetyl-L-cysteine (NAC) , a scavenger of reactive oxygen species . Positive_regulation IL6 TNF 7934096 275455 A local production of these cytokines can not be excluded , because [interleukin-6] and interleukin-8 are produced by stimulated macrophages and monocytes in *response* to and interleukin-1 beta . Positive_regulation IL6 TNF 7948751 277308 D-factor and *increased* [IL-6] production in 3T3-L1 cells . Positive_regulation IL6 TNF 7955543 277816 *induced* [IL-6] production was also potentiated in a dose dependent manner by histamine , without modification of the time course of IL-6 secretion . Positive_regulation IL6 TNF 7970084 280015 No significant [IL-6] production by PTEC could be *induced* by , IL-2 , IFN gamma , or LPS over a broad dosage range . Positive_regulation IL6 TNF 8034659 264309 Differential *induction* of the [interleukin-6] gene by and interleukin-1 . Positive_regulation IL6 TNF 8034659 264555 IL-1 induces IL-6 gene expression after 30 min of IL-1 treatment , reaching a maximum level by 7 h , and is sustained for up to 14 h . also *induces* the [IL-6] gene expression at 30 min but the induction was low . Positive_regulation IL6 TNF 8034659 264557 These results suggest that the *induction* of the [IL-6] gene expression in primary human fibroblasts by and IL-1 is differentially regulated at the transcriptional as well as at the post-transcriptional level . Positive_regulation IL6 TNF 8057147 268045 [Interleukin-6] secretion was remarkably *stimulated* by , IL-1 beta , and IL-4 , and was also influenced by a combination of epidermal growth factor and bromocriptine . Positive_regulation IL6 TNF 8061104 268518 Cell populations from various sites including peripheral blood , bone marrow , lymph nodes , and osteolytic bone lesions were cultured and tested for spontaneous or IL-1 *induced* [IL-6] production in a sensitive bioassay . Positive_regulation IL6 TNF 8069430 269948 The [IL-6] secretion by skin explants was significantly *enhanced* either by or interleukin-1 , while it was inhibited by corticosteroids . Positive_regulation IL6 TNF 8089606 271813 IL-1 and synergistically *augmented* [IL-6] production to stimulate hCG production . Positive_regulation IL6 TNF 8108469 246181 Both IL-1 and can *induce* the synthesis of [IL-6] by a variety of cells . Positive_regulation IL6 TNF 8123700 242018 Activation of the nuclear factor kappa B is not sufficient for regulation of *induced* [interleukin-6] gene expression . Positive_regulation IL6 TNF 8123700 242019 Also activation of NF-kappa B as a function of time following TNF treatment did not reveal a correlation between the abundance of the protein/DNA complex and the *induced* [IL-6] mRNA levels . Positive_regulation IL6 TNF 8132326 251531 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL6 TNF 8176222 255775 However , the *induction* of high levels of circulating [IL-6] by murine was not affected , although IL-1ra almost completely blocked the induction of IL-6 by exogenously administered IL-1 . Positive_regulation IL6 TNF 8199531 259487 Prompted by this evidence , we have now examined whether and/or IL-1 are produced by murine calvarial cells , and whether these cytokines are *involved* in [IL-6] production and osteoclast formation . Positive_regulation IL6 TNF 8199531 259496 These findings suggest that TNF , but not IL-1 , is produced by murine bone cells and that endogenous *induces* the [IL-6] production , osteoclast formation , and bone resorption exhibited by these cultures under basal conditions . Positive_regulation IL6 TNF 8227350 235648 In addition , [IL-6] secretion by HCs was markedly *augmented* by . Positive_regulation IL6 TNF 8227350 235649 Finally , although neither IL-6 nor anti-IL-6 antibody altered TNF induced DNA synthesis by HCs , IL-6 antisense oligonucleotide inhibited *induced* DNA synthesis and [IL-6] secretion by HCs . Positive_regulation IL6 TNF 8231032 235888 Bioactive [IL-6] was *detected* in all culture supernatants while bioactive was not detected . Positive_regulation IL6 TNF 8344250 226432 This depletion of the mitochondrial oxidative metabolism resulted in resistance towards TNF cytotoxicity , as well as in inhibition of NF kappa B activation and [interleukin-6] gene *induction* by . Positive_regulation IL6 TNF 8344757 226488 LPS , IL-1 alpha , and strongly *enhanced* the release of [IL-6] by RCC cells , but only marginally affected IL-10 production in colon-carcinoma cells . Positive_regulation IL6 TNF 8386026 215059 Because *induces* production of [interleukin-6 (IL-6)] , which has been shown to be a growth factor for myeloma and other transformed B cells , we examined the possibility that IL-6 mediates the growth-stimulatory effect of TNF on B-CLL cells . Positive_regulation IL6 TNF 8388171 218236 On the other hand , co-injection of sTNFrI and LPS decreased IL-6 levels in BAL fluid , most likely by interfering with the *induction* of [IL-6] by . Positive_regulation IL6 TNF 8409382 233334 3 ) *induces* direct thymocyte apoptosis ( a property not shared by IL-1 beta , IL-2 , IL-4 , [IL-6] and IL-7 ) . Positive_regulation IL6 TNF 8476629 218511 *induction* of [IL-6] and GM-CSF was amplified synergistically in infected cultures . Positive_regulation IL6 TNF 8495426 219512 In the L929 fibrosarcoma cell line , staurosporine also enhanced the transcriptional *activation* of [interleukin 6] synthesis by ( 500-fold stimulation at 56 nM ) . Positive_regulation IL6 TNF 8579900 326537 Even though these observations establish that IL-6 is an essential pathogenetic factor in the bone loss caused by gonadal deficiency , it remains unclear whether [IL-6] is the sole pathogenetic factor or whether IL-1 , , and IL-11 may also be *involved* . Positive_regulation IL6 TNF 8585654 341361 *mediated* [IL-6] , lactate , and prostacyclin responses , without affecting thromboxane production in horses given LPS . Positive_regulation IL6 TNF 8589669 341857 Five high molecular weight glycolipids capable of stimulating human peripheral whole-blood cell cultures to cause [interleukin 6 (IL-6)] and *induction* were isolated from one of the lipoteichoic acid fractions ( LTA-2 ) extracted from Enterococcus hirae ATCC 9790 ( Tsutsui et al. , ( 1991 ) FEMS Microbiol . Positive_regulation IL6 TNF 8592105 341921 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL6 TNF 8592105 341976 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL6 TNF 8624246 360188 In the same cultures , induced marked *increases* in release of both IL-8 and [IL-6] at 24 and 48 h after stimulation . Positive_regulation IL6 TNF 8627304 355867 Whereas activation of protein kinase A was able to induce expression of the IL-6 gene , it did not induce gene expression and was not *involved* in IL-1 beta induced [IL-6] and TNF alpha gene expression . Positive_regulation IL6 TNF 8635282 362046 and interleukin-1 (IL-1) *enhanced* [IL-6] secretion and IL-6 mRNA transcription in AFb of SA patients . Positive_regulation IL6 TNF 8666148 369073 The results of this study demonstrate that hyperglycemia stimulated IL-6 and TNF synthesis and secretion by human peripheral monocytes in vitro and that the [IL-6] response to hyperglycemia may be *mediated* by . Positive_regulation IL6 TNF 8682145 372536 Our results indicate that the leukocyte derived production of [IL-6] and IL-1 beta in whole blood is stimulated directly by endotoxin and is not *mediated* by . Positive_regulation IL6 TNF 8683105 370239 IL-12 and/or [IL-6] can *induce* the expression of IL-10 by PHA stimulated T cells , whereas induces IL-10 production by monocytes . Positive_regulation IL6 TNF 8724532 376737 Spontaneous [IL-6] protein release was enhanced in the *presence* of ( 100 U/ml and 250 U/ml ) by CLL cells at 48 hours of culture 143.6 % and 172 % ( p < 0.05 , n = 6 ) . Positive_regulation IL6 TNF 8724991 373819 Given that IL-1 and , monokines derived from microglia , *induce* [IL-6] production in astrocytes , but not in microglia , results indicate that astrocytes and microglia may mutually regulate IL-6 production by different cytokines . Positive_regulation IL6 TNF 8770299 379289 4JK tumor was further tested to determine if IL-1 , , or cocultivation with RAW 264 cells *augmented* [IL-6] or LIF production . Positive_regulation IL6 TNF 8805054 382205 In contrast , stimulation of the cells with *resulted* in an equal level of [IL-6] secretion to the apical and basal surfaces , regardless of whether the cells were stimulated by the apical or basal route . Positive_regulation IL6 TNF 8810592 383330 The degree of PMN activation *increased* with the degree of lung injury and with the levels of , [interleukin-6 (IL-6)] , and interleukin-8 (IL-8) . Positive_regulation IL6 TNF 8890233 391894 P < 0.05 ) , the TNF-alpha and [IL-6] concentrations decreased , and the time-to-peak expression *increased* . Positive_regulation IL6 TNF 8895322 392456 Finally , interleukin-1 beta and ( 1-1000 pM ) *stimulated* dose dependent increases in the secretion of [interleukin-6] and monocyte chemoattractant protein-1 at 34 C and 40C . Positive_regulation IL6 TNF 8910536 395218 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL6 TNF 8950209 400737 The [IL-6] production was greatly *enhanced* by IL-1 alpha , but not by IL-6 , or interferon-gamma . Positive_regulation IL6 TNF 8955207 401352 Finally , we investigated the role of p55 and p75 in [IL-6] *induction* by in a murine brain endothelioma . Positive_regulation IL6 TNF 8955207 401357 These data indicate that p55 plays a major role in TNF activation of the hypothalamus-pituitary-adrenal axis and in the centrally mediated *induction* of peripheral [IL-6] by , but p75 , despite having little IL-6 inductive properties by itself , seems to potentiate p55 induction of IL-6 . Positive_regulation IL6 TNF 8979262 403701 The relationship between altered membrane composition , eicosanoids and *induced* IL1 and [IL6] production in macrophages of rats fed fats of different unsaturated fatty acid composition . Positive_regulation IL6 TNF 9046030 416701 The effects of different dietary fats on peritoneal macrophage plasma membrane fluidity , intracellular cyclic AMP ( cAMP ) production , GTP hydrolysis and TNF binding and *induced* IL1 and [IL6] production was investigated . Positive_regulation IL6 TNF 9058758 417685 In particular , promotes oligodendrocyte and myelin pathology , and [IL-6] expression is *induced* in astrocyte and microglial cultures that have been incubated with TNFalpha or myelin debris , respectively . Positive_regulation IL6 TNF 9087647 421677 The data indicate that IL-1 and *act* locally at the site of inflammation and that locally induced [IL-6] is the important systemic mediator of the response . Positive_regulation IL6 TNF 9089655 421878 Hence , [IL-6] is *induced* by via activation of PTK . Positive_regulation IL6 TNF 9162522 389373 [IL-6] expression in transformed swine testicular (TST) fibroblasts was *enhanced* by and IL-1 beta and to a lesser extent by poly ( I ) . Positive_regulation IL6 TNF 9186079 436770 Exposure to VLDL , IDL , LDL , or a high concentration of HDL *enhanced* the secretion of [interleukin-6] , platelet derived growth factor , and transforming growth factor-beta by mesangial cells , whereas secretion was stimulated by oxidized LDL . Positive_regulation IL6 TNF 9203532 440292 Third , TNF stimulates ACTH synthesis in AtT-20 cells , while *increases* immunoreactive [interleukin (IL)-6] release from TtT/GF cells . Positive_regulation IL6 TNF 9209275 441019 TBP I completely abolished *induced* [IL-6] production and E-selectin induction , while it partially inhibited TNF induced IL-8 production and up-regulation of ICAM-1 and VCAM-1 . Positive_regulation IL6 TNF 9209508 441112 The [IL-6] response of parasitized astroglia was *up-regulated* by external and transforming growth factor (TGF)-beta 1 , with only TNF-alpha enhancing simultaneous release of IL-1 . Positive_regulation IL6 TNF 9245870 446312 There was little change in levels between preoperative and recovery samples but [IL-6] concentrations *increased* three-fold , particularly in those with large recent burns or bacteraemia , and were correlated with poor clinical outcome . Positive_regulation IL6 TNF 9282830 451533 Interleukin-1 (IL-1) and [IL-6] were *induced* in monocytes by all superantigens , whereas was induced in T cells and by some superantigens , also in monocytes . Positive_regulation IL6 TNF 9309381 454745 In human osteoblastic cells ( SaOS2 ) both basal and *stimulated* [IL6] production were inhibited in a concentration related manner by SK & F 86002 but not by indomethacin . Positive_regulation IL6 TNF 9312119 455423 We investigated the mechanism of [interleukin-6 (IL-6)] synthesis *induced* by in osteoblast-like MC3T3-E1 cells . Positive_regulation IL6 TNF 9312119 455424 stimulated the synthesis of IL-6 dose dependently in the range between 1 and 30 ng/ml. Staurosporine and calphostin C , inhibitors of protein kinase C ( PKC ) , significantly *enhanced* the TNF induced synthesis of [IL-6] . Positive_regulation IL6 TNF 9312119 455425 1-Oleoyl-2-acetylglycerol , a specific activator of PKC , inhibited the *induced* [IL-6] synthesis . Positive_regulation IL6 TNF 9312119 455426 The *induced* [IL-6] synthesis was significantly enhanced by D-609 . Positive_regulation IL6 TNF 9312119 455427 These results strongly suggest that sphingosine 1-phosphate may act as a second messenger for *induced* [IL-6] synthesis and that TNF autoregulates IL-6 synthesis due to PKC activation via phosphatidylcholine-specific phospholipase C in osteoblast-like cells . Positive_regulation IL6 TNF 9329125 457456 The regulation of IL-6 production in the enterocyte may be specific for IL-1 beta , since neither nor IL-6 *stimulated* [IL-6] production . Positive_regulation IL6 TNF 9368513 463836 The secretion of [IL-6] can be *stimulated* by interleukin-1 (IL-1) , , serum , TSH and agents which increase intracellular cyclic AMP levels . Positive_regulation IL6 TNF 9369355 464012 The results demonstrate that is a much stronger *inducer* of fever and [interleukin-6] production or of HPA-axis activation than TNF-beta in so far as all the investigated responses can be measured for prolonged time in response to TNF-alpha . Positive_regulation IL6 TNF 9391055 467720 Upon investigating DEX mediated repression of [interleukin-6] expression *induced* by , DEX treatment was found to act directly on NF-kappaB dependent transcription , without changing the expression level of IkappaB . Positive_regulation IL6 TNF 9393813 467926 In addition , dexamethasone was found to stimulate [IL-6] and IL-8 secretion ( in the presence or absence of LPS ) but did not *induce* any secretion of . Positive_regulation IL6 TNF 9393919 468015 Both IL-1beta and *stimulated* [IL-6] and PGE2 release from the osteoblast-like cells . Positive_regulation IL6 TNF 9401927 469520 This result suggests that endogenous prostaglandin E2 ( PGE2 ) partially inhibits IL-1 or *induced* [IL-6] production and that the enhancement of IL-6 production by IL-1 or TNF-alpha may not be caused through endogenous PGE2 induced cAMP dependent pathway . Positive_regulation IL6 TNF 9401927 469522 Dexamethasone ( DEX ) , a glucocorticoid which is a inhibitor of nuclear factor kappa B ( NF-kappa B activation , markedly inhibited IL-1 ( alpha or beta ) or *induced* [IL-6] production ; so this production may be partially mediated through NF-kappa B . IL-1 ( alpha or beta ) and TNF-alpha enhanced IL-6 production synergistically . Positive_regulation IL6 TNF 9452444 484111 In the mouse fibrosarcoma cell line L929 , the nuclear factor (NF)-kappaB plays a crucial role in [IL-6] gene expression *mediated* by . Positive_regulation IL6 TNF 9452444 484114 We observed that the p38 mitogen activated protein kinase (MAPK) inhibitor SB203580 was able to repress *stimulated* expression of the [IL-6] gene , as well as of a kappaB dependent reporter gene construct , without affecting the levels of NF-kappaB binding to DNA . Positive_regulation IL6 TNF 9452444 484115 Therefore , we conclude that , in addition to cytoplasmic activation and DNA binding of NF-kappaB , the p38 and extracellular signal regulated kinase MAPK pathways act as necessary cooperative mechanisms to regulate *induced* [IL-6] gene expression by modulating the transactivation machinery . Positive_regulation IL6 TNF 9453616 484279 Although *stimulated* [IL-6] production by HGF , > 10-fold-larger amounts were induced with IL-1alpha and IL-1beta . Positive_regulation IL6 TNF 9469441 485884 The vasoactive peptide maxadilan from sand fly saliva inhibits and *induces* [IL-6] by mouse macrophages through interaction with the pituitary adenylate cyclase activating polypeptide ( PACAP ) receptor . Positive_regulation IL6 TNF 9528954 496221 These results strongly suggest that TNF-alpha increases the IL-6 gene expression through the activation of NF-kappaB in the thyroid cells , and that antioxidants suppress the *dependent* [IL-6] expression by inhibiting the activation of the transcriptionally active NF-kappaB . Positive_regulation IL6 TNF 9558730 500202 that *induced* IL1 and [IL6] production relate in a positive curvilinear fashion to linoleic acid intake ; Positive_regulation IL6 TNF 9576614 502836 We found that IL-1beta , and lipopolysaccharide (LPS) *stimulated* myoblast [IL-6] secretion in a dose- and time dependent manner , whereas forskolin and cholera toxin did not . Positive_regulation IL6 TNF 9576614 502837 HA1004 at 10 microM did not significantly affect the IL-1beta- and *induced* [IL-6] secretion , suggesting that cAMP and protein kinase A are not sufficient to stimulate this process . Positive_regulation IL6 TNF 9584910 504450 In contrast to its effect on IL-1beta , triclosan did not influence the mRNA expression or the production of [IL-6] *induced* by . Positive_regulation IL6 TNF 9593700 505730 Given the high levels of soluble receptor in synovial fluid and the marked *induction* of [IL-6] by IL-1 or , it is likely that IL-6 and its soluble receptor are critical in controlling the catabolic effects of pro-inflammatory cytokines . Positive_regulation IL6 TNF 9607578 508530 Suppression of IL-2 mediated alpha and [IL-6] *induction* in vivo during the first 24 h after IL-2 administration was observed , and the neutrophil chemotactic defect normally seen with IL-2 was not observed . Positive_regulation IL6 TNF 9631748 512580 Finally , *increased* the levels of [IL-6] and NO in the supernatants of synoviocytes ; Positive_regulation IL6 TNF 9649471 516468 After 24 hours of EtOH exposure , the release of IL-1 alpha doubled , that of [IL-6] increased 10 times , and that of *increased* 3.5 times . Positive_regulation IL6 TNF 9660992 518032 Inhibition of *contributed* to erythromycin induced inhibition of [IL-6] synthesis . Positive_regulation IL6 TNF 9675546 520356 KE-298 significantly suppressed *induced* production of promatrix metalloproteinase-1 and [IL-6] , in a dose dependent manner , but not that of tissue inhibitor-1 of metalloproteinases . Positive_regulation IL6 TNF 9706871 526303 In addition , we have shown that basic fibroblast growth factor (bFGF) elicits IL-6 synthesis through intracellular Ca2+ mobilization in these cells and that *induces* [IL-6] synthesis through sphingosine 1-phosphate produced by sphingomyelin hydrolysis . Positive_regulation IL6 TNF 9706871 526333 On the contrary , sphingosine enhanced the *induced* [IL-6] synthesis . Positive_regulation IL6 TNF 9718198 528190 also *increased* the mRNA levels of [interleukin-6 (IL-6)] and intercellular adhesion molecule-1 ( ICAM-1 ) . Positive_regulation IL6 TNF 9718198 528194 An antioxidant , N-acetyl-L-cysteine , significantly attenuated the TNF-alpha dependent increase in these mRNAs , and simultaneously reduced the activation of NF-kappaB by TNF-alpha , indicating that NF-kappaB mediates the *dependent* expression of [IL-6] and ICAM-1 in ROS17/2.8 cells . Positive_regulation IL6 TNF 9728802 530069 The synthesis of [IL-6] was significantly *enhanced* by in BMMC and ALL-T while the presence of TNF-alpha had no effect on IL-6 synthesis in the culture of cALL leukemic cells . Positive_regulation IL6 TNF 9740146 531991 Interleukin-1beta , ( 100 pmol/L ) , ( 1 nmol/L ) , and lipopolysaccharide ( 1 microg/mL ) each *increased* the release of [IL-6] , IL-8 , and monocyte chemoattractant protein-1 by MaMi cells . Positive_regulation IL6 TNF 9769153 538704 We have determined that the human colonic carcinoma cell line Caco-2 is capable of secreting IL-6 when stimulated by the inflammatory cytokines IL-1beta or tumor necrosis factor-alpha (TNF-alpha) , and stimulation of these cells with IL-1beta plus *induced* a synergistic enhancement of [IL-6] secretion . Positive_regulation IL6 TNF 9777287 540246 The other proinflammatory cytokines IL-1 beta , and remained unchanged , and the increased serum [IL-6] did not *induce* production of c-reactive protein . Positive_regulation IL6 TNF 9792466 542541 We observed that ( 1 ) IL-1beta and *induced* [IL-6] in a dose and time dependent fashion , ( 2 ) TGFbeta 1 and 2 enhanced basal and IL-1beta and TNFalpha induced IL-6 expression , ( 3 ) ET-1 elicited a dose dependent stimulatory effect on IL-6 expression . Positive_regulation IL6 TNF 9792645 542611 Underscoring the physiological significance of c-Src activation of NF-kappaB , *induction* of [IL-6] , which is an NF-kappaB mediated event , is substantially diminished in c-src-/- BMMs . Positive_regulation IL6 TNF 9794740 543097 Transcription factor decoy for nuclear factor-kappaB inhibits *induced* expression of [interleukin-6] and intracellular adhesion molecule-1 in endothelial cells . Positive_regulation IL6 TNF 9794740 543120 Also nuclear factor-kappaB decoy oligodeoxynucleotides but not scrambled oligodeoxynucleotides inhibited *induced* expression of [interleukin-6] and intracellular adhesion molecule-1 both at the messenger RNA and at protein level ( assessed by reverse transcription-polymerase chain reaction and enzyme linked immunosorbent assay ) . Positive_regulation IL6 TNF 9988429 560278 It also increases *induced* [IL-6] production and expression of adhesion molecules . Positive_regulation IL6 TNFSF10 10807904 736593 Moreover , in these cell lines [interleukin-6] secretion and NF-kappaB activation were *induced* by cross linked or non-cross linked , as well as by both receptor-specific IgGs . Positive_regulation IL6 TNNT2 15269990 1276198 In both groups serum [IL-6] , IL-8 , CK-MB and levels *increased* significantly after aorta declamping ( especially from 2 h after aorta declamping ) compared with preoperative levels ( P < 0.05 ) . Positive_regulation IL6 TP63 15126418 1244845 These findings suggest that would *regulate* the cell adhesive property through ICAM-1/LFA-1 interaction and the production of [IL-6] and IL-8 , probably in all TEC subtypes . Positive_regulation IL6R ADAM10 20026129 2217741 The release of the [IL6R] is *mediated* by the disintegrin and metalloproteinases and ADAM17 . Positive_regulation IL6R ANXA6 7907329 250403 These findings demonstrate that nascent unfolded is tethered to calnexin during normal protein maturation , including the formation and editing of disulfide bonds and that ATP is *required* for the productive interaction of [gp80] and calnexin . Positive_regulation IL6R CEBPA 14960573 1227729 is *required* for [interleukin-6 receptor] alpha signaling in newborn hepatocytes . Positive_regulation IL6R EGFR 24047696 2862781 Cellular senescence or signaling *induces* [Interleukin 6 (IL-6) receptor] expression controlled by mammalian target of rapamycin (mTOR) . Positive_regulation IL6R IL3RA 9389693 467185 Although peripheral blood derived CD34 ( + ) cells ubiquitously expressed gp130 and ( IL-3Ralpha ) , [IL-6Ralpha] was only *detected* on 80 % of these CD34 ( + ) cells . Positive_regulation IL6R IL6 18942191 1978238 In one of three experiments , *induced* CCL2 secretion , whereas interleukin-6 plus soluble [interleukin-6 receptor] induced CCL2 secretion in all three experiments , suggesting that both direct interleukin-6 signaling and interleukin-6 trans signaling may be involved . Positive_regulation IL6R IL6 19006119 2016433 ( 10 ng/ml ) *increased* the level of [IL-6Ralpha] and glycoprotein (gp) 130 ( IL-6Rbeta ) protein expressions . Positive_regulation IL6R IL6 19088449 2003718 ( 10 ng/ml ) *increased* the level of [IL-6Ralpha] and glycoprotein (gp) 130 ( IL-6Rbeta ) protein expression , Janus Kinase (JAK) 2 , signal transducer and activator of transcription ( STAT ) 3 , PKC , p44/42 MAPKs phosphorylation , and PPARdelta protein expression . Positive_regulation IL6R IL6 8898888 393150 Interleukin-6 itself had no effect on synovial lining cells but a complex of and the soluble [interleukin-6 receptor] induced *activation* of signal transducer and activator of transcription ( STAT ) factors in these cells and regulated TIMP-1 and TIMP-3 expression in a similar fashion as oncostatin M . Positive_regulation IL6R IL6 9714910 527748 Expression of [interleukin-6 (IL-6) receptor] gene in acute myeloblastic leukemia and *response* of leukemic cells to exogenous . Positive_regulation IL6R LRPPRC 9389693 467184 Although peripheral blood derived CD34 ( + ) cells ubiquitously expressed and interleukin-3 receptor alpha ( IL-3Ralpha ) , [IL-6Ralpha] was only *detected* on 80 % of these CD34 ( + ) cells . Positive_regulation IL6R NGF 8858917 388465 also *induced* expression of the [gp80] subunit of the IL-6 receptor , providing another potential mechanism of cooperativity between NGF and IL-6 signaling . Positive_regulation IL6ST CCND1 21847632 2524277 We found that , in lung cancer cell lines and in nude mice , Interleukin-7/Interleukin-7 receptor increased the expression of and phosphorylation of c-Fos/c-Jun , *induce* c-Fos and c-Jun [heterodimer] formation , and enhanced c-Fos/c-Jun DNA binding activity to regulate cyclin D1 . Positive_regulation IL6ST PLAU 10446176 636381 This new *induced* Stat2-Stat1 [heterodimer] binds to GAS ( the interferon-gamma activation site ) distinct from the interferon stimulated response element to which the p48 protein containing complexes generally bind . Positive_regulation IL6ST TNF 1378269 190593 *Enhancement* of IL-6 receptor beta chain ( [gp130] ) expression by IL-6 , IL-1 and in human epithelial cells . Positive_regulation IL6ST TNF 15677444 1395382 We identified importin alpha3 and importin alpha4 as the main importin alpha isoforms mediating *stimulated* NF-kappaB p50/p65 [heterodimer] translocation into the nucleus . Positive_regulation IL6ST TNF 16604092 1562647 In accordance with this result , rosmarinic acid also inhibited TNF-alpha induced phosphorylation and degradation of IkappaB-alpha , as well as nuclear translocation of NF-kappaB [heterodimer] *induced* by . Positive_regulation IL6ST TNF 17675290 1794080 By electrophoretic mobility shift assay analyses , and lipopolysaccharide *induce* strong p65/p50 and p65/c-Rel [heterodimer] binding to both NF-kappaB and TF-kappaB probes . Positive_regulation IL6ST TNF 18684959 1949169 Correspondingly , in vitro infected GFAP-Cre gp130 ( fl/fl ) astrocytes inhibited the growth of T. gondii efficiently after stimulation with IFN-gamma , whereas neighboring noninfected and *stimulated* GFAP-Cre [gp130] ( fl/fl ) astrocytes became apoptotic . Positive_regulation IL6ST TNF 21484152 2428309 Western blot analysis allowed assessing the inhibitory effect of the neem extract on *induced* degradation of inhibitor of ?B ( I?B ) and nuclear translocation of the NF-?B p50/p65 [heterodimer] . Positive_regulation IL6ST TNF 22334708 2580727 Knockdown analysis using 293FT reporter cells that endogenously express these five proteins at low levels clearly showed that DPF3a and DPF3b , which are produced from the DPF3 gene by alternative splicing , are the most critical for the RelA/p50 NF-?B [heterodimer] transactivation *induced* by stimulation . Positive_regulation IL6ST TNF 9528954 496216 The treatment with the antioxidants 20 mM N-acetyl-L-cysteine (NAC) and 10 microM pyrrolidine dithiocarbamate ( PDTC ) inhibited the *dependent* activation of p65-p50 [heterodimer] but not the p50-p50 homodimer , indicating that generation of oxidants is required for the activation of the heterodimer NF-kappaB . Positive_regulation IL6ST TP63 9614940 509535 In order to elucidate the *role* of in the [heterodimer] , chimeric HIV-1/FIV RT heterodimers were constructed and characterized . Positive_regulation IL7 ABCG2 20846001 2375408 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL7 CCL17 22057112 2540327 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL7 CCND1 21847632 2524298 Taken together , our results provided evidence that [Interleukin-7/Interleukin-7] receptor *induced* up-regulation via c-Fos/c-Jun pathway to promote proliferation of cells in lung cancer . Positive_regulation IL7 DAPK1 24220855 2897452 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL7 EPHB2 12609986 1085303 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL7 EPHB2 18310510 1904159 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL7 F3 7635444 317288 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL7 FAS 17404319 1722060 IL-7 treatment primed T cells for *induced* apoptosis in vitro and serum [IL-7] levels correlated with the sensitivity of T cells to Fas induced apoptosis in HIV infected individuals . Positive_regulation IL7 IL1B 14617515 1200648 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL7 IL1B 16375968 1547164 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL7 IL1B 2007858 154858 In addition to promoting IL-6 production , [IL-7] *induced* the secretion of immunoreactive IL-1 alpha , , and tumor necrosis factor alpha (TNF-alpha) by monocytes . Positive_regulation IL7 IL1B 20497296 2289066 The *role* of in reduced [IL-7] production by stromal and epithelial cells : a model for impaired T-cell numbers in the gut during HIV-1 infection . Positive_regulation IL7 IL1R2 8387521 218044 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL7 ITGB2 11449367 836570 Furthermore , we also demonstrated that IL-2 , [IL-7] and IL-15 could *induce* de novo the synthesis of and CD2 . Positive_regulation IL7 PECAM1 10804726 691943 [Interleukin-7] preserved the population of CD4+CD31- T cells in cord blood and *induced* their IL-4 producing ability without T cell receptor ( TCR ) stimulation , while IL-4 induced on CD31- T cells and could not induce their IL-4 producing ability . Positive_regulation IL7 PGC 22117073 2535022 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL7 STAT4 7638186 317687 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL7 TLR7 12045249 950127 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL7 TLR7 18312842 1879494 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Positive_regulation IL7 TLR7 19285437 2051532 Thus , T cell responses are regulated by hepatocyte derived [IL-7] , which is expressed in *response* to signaling in vivo . Positive_regulation IL7 TLR7 19285437 2051552 We suggested that *induced* [IL-7] expression in the liver , which is an acute-phase response , may be a good diagnostic and therapeutic target for efficient vaccine developments and for conditions characterized by TLR mediated T cell dysregulation , including autoimmune diseases . Positive_regulation IL7 TLR7 20632067 2368019 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in mediated *activation* of caspase 1 and [interleukin-1ß] . Positive_regulation IL7 TLR7 22521509 2613629 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL7 TLR7 23246311 2732189 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL7 TNF 10961889 726607 We now show that interleukin-1 (IL-1) and , cytokines typically produced in inflammatory conditions , *increase* the stromal cell production of [IL-7] . Positive_regulation IL7 TNF 10961889 726609 On the basis of our data , we propose a novel mechanism for inflammatory bone loss in which *induction* of [IL-7] from stromal cells by IL-1 and leads to the production of soluble osteoclastogenic cytokines by T cells . Positive_regulation IL7 TNF 1463043 206774 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL7 TNF 17854477 1795899 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving dependent [interleukin-12] *induction* . Positive_regulation IL7 TNF 2007858 154856 In addition to promoting IL-6 production , [IL-7] *induced* the secretion of immunoreactive IL-1 alpha , IL-1 beta , and by monocytes . Positive_regulation IL7 TNF 2113076 135554 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL7 TNF 21745554 2471931 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL7 TNF 2370931 138357 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL7 TNF 3011946 59766 interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL7 TNF 3486658 59965 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL7 TNF 3486658 60019 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL7 TNF 3486936 60108 Tumor necrosis factor ( ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL7 TNF 3500495 80717 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL7 TNF 3526909 62658 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL7 TNF 7506142 237754 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL7 TNF 7737374 305526 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL7 TNF 8132326 251532 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL7 TNF 8409382 233335 3 ) *induces* direct thymocyte apoptosis ( a property not shared by IL-1 beta , IL-2 , IL-4 , IL-6 and [IL-7] ) . Positive_regulation IL7 TNF 8592105 341922 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL7 TNF 8592105 341977 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL7 TNF 8910536 395219 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL7R CCND1 21847632 2524299 Taken together , our results provided evidence that [Interleukin-7/Interleukin-7 receptor] *induced* up-regulation via c-Fos/c-Jun pathway to promote proliferation of cells in lung cancer . Positive_regulation IL7R FOXO1 19136962 2025519 Furthermore , deficiency *resulted* in a severe defect in interleukin 7 receptor alpha-chain ( [IL-7Ralpha] ) expression associated with its ability to bind an Il7r enhancer . Positive_regulation IL7R FOXO1 19136962 2025520 Finally , growth factor withdrawal induced a *dependent* increase in Sell , Klf2 and [Il7r] expression . Positive_regulation IL7R TLR7 20566828 2285313 These data define that induced *activation* of CD3 ( neg ) [CD127] ( + ) cells and production of Th17 related cytokines may be crucial for the early defenses against pathogen invasion of host tissues . Positive_regulation IL7R TNF 10779425 687448 The effect *resulted* in an up-regulation of [CD127] ( ie , the IL-7 receptor alpha-chain ) in a small subset of the CD34+ cells . Positive_regulation IL8 ABCG2 20846001 2375409 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL8 ALOX5 15028114 1243979 The data indicate that ML 3000 affects acid-secretory mechanisms downstream of cAMP mobilization induced by histamine H2 receptor activation , that it directly inhibits H , K-ATPase specific activity , and that baseline gastric epithelial cell [IL-8] secretory inhibition may be *mediated* by ML 3000 inhibition of <5-lipoxygenase> activity . Positive_regulation IL8 ANGPT1 18252863 1890744 Upstream from the AP-1 complex , *up-regulation* of [IL-8] transcription by was mediated through the Erk1/2 , SAPK/JNK , and PI-3 kinase pathways , which triggered c-Jun phosphorylation on Ser63 and Ser73 . Positive_regulation IL8 ANGPT1 22015631 2585098 but not angiopoietin-2 *induces* [IL-8] synthesis and release by human neutrophils . Positive_regulation IL8 ANGPT1 22015631 2585100 ( 10 ( -8 ) M ) induced a significant and maximal increase of IL-8 mRNA ( 4.7-fold ) within 1 h , and *promoted* maximal [IL-8] protein synthesis ( 3.6-fold ) and release ( 5.5-fold ) within 2 h as compared to control PBS treated neutrophils . Positive_regulation IL8 ANGPT1 22015631 2585101 Neutrophil pretreatment with a protein synthesis inhibitor ( CHX ) increased IL-8 mRNA synthesis by 18-fold , and reduced *mediated* [IL-8] protein synthesis and release by 96 % and 92 % , respectively . Positive_regulation IL8 ANGPT1 22198097 2549647 We also observed that , but not Ang2 can *promote* [IL-8] release and that a pretreatment of the neutrophils with blocking anti-IL-8 antibodies inhibited the anti-apoptotic effect of IL-8 and Ang1 by 92 and 81 % respectively . Positive_regulation IL8 CAPN8 15985533 1428609 We observed a smoke extract induced , *dependent* degradation of the intracellular form of platelet-endothelial cell adhesion molecule 1/CD31 , as well as a release of P-selectin/CD62P , IL-6 , and [IL-8] from endothelial cells into the supernatant . Positive_regulation IL8 CCL17 22057112 2540328 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL8 CD14 12410798 1010659 mediated *induction* of [interleukin-8] and monocyte chemoattractant protein-1 by a heat-resistant constituent of Porphyromonas gingivalis in endothelial cells . Positive_regulation IL8 CD14 12458377 1032172 However , was not *required* for LPS mediated induction of [IL-8] in HT-29/p cells since neutralizing anti-CD14 antibodies left IL-8 levels unchanged . Positive_regulation IL8 CD14 14500479 1143933 Augmentation of Actinobacillus actinomycetemcomitans invasion of human oral epithelial cells and *up-regulation* of [interleukin-8] production by saliva . Positive_regulation IL8 CD14 14500479 1143934 The internalization of A. actinomycetemcomitans Y4 into HSC-2 cells was inhibited by cytochalasin B , indicating that the process was actin dependent , and depletion of from parotid saliva inhibited the invasion and , as a consequence , *inhibited* production of [IL-8] . Positive_regulation IL8 CD14 14500479 1143935 Furthermore , human recombinant *augmented* invasion and [IL-8] production . Positive_regulation IL8 CD14 14500479 1143936 These results suggest that saliva promoted the invasion of oral epithelial cells by A. actinomycetemcomitans and consequently *augmented* the production of [IL-8] , playing an important role in innate immunity in the oral cavity . Positive_regulation IL8 CD14 16249503 1471753 In a dose-dependant manner , tear and LBP *mediated* the secretion of interleukin (IL)-6 and [IL-8] by corneal epithelia cells when challenged with LPS . Positive_regulation IL8 CD14 20019359 2247965 [CXCL8] secretion by LPS treated IPE was *dependent* on and TLR4 . Positive_regulation IL8 CD14 23720457 2811580 [IL-8] release induced by Re-LPS , which does not *require* to activate TLR4 , was insensitive to both bosentan and BQ788 . Positive_regulation IL8 CD14 7681082 214211 We conclude that is *involved* in LPS induced release of TNF-alpha , IL-6 , and [IL-8] by monocytes and alveolar macrophages and that this receptor appears to be able to recognize LPS directly in the absence of serum . Positive_regulation IL8 CHI3L1 21546314 2463962 Downstream , *enhanced* the secretion of [IL-8] and TNFa in a dose dependent manner . Positive_regulation IL8 CHI3L1 21763261 2466932 Purified efficiently activated the NF-?B signaling pathway and *enhanced* the secretion of [IL-8] and TNF-a in SW480 human colon cancer cells . Positive_regulation IL8 CHI3L1 23197259 2718271 *induces* [IL-8] expression from bronchial epithelium via MAPK ( JNK and ERK ) and NF-?B pathways , causing bronchial smooth muscle proliferation and migration . Positive_regulation IL8 CHI3L1 23197259 2718272 *induced* [IL-8] was found to further stimulate proliferation and migration of BSMCs , and the effects were inhibited after neutralizing IL-8 . Positive_regulation IL8 DAPK1 24220855 2897455 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL8 EPHB2 12055070 951588 In contrast , ERK and p38 inhibition resulted in the accelerated degradation of the IL-8 mRNA , suggesting that in HT-29 cells , p38 and *contribute* to TNF-alpha stimulated [IL-8] secretion by intestinal epithelial cells via a posttranscriptional mechanism that involves stabilization of the IL-8 transcript . Positive_regulation IL8 EPHB2 12388360 1035041 Finally , although activation was *required* for maximal asialoGM1 mediated [IL-8] expression , inhibition of ERK signaling had no effect on IKK or NF-kappaB activation , suggesting that ERK regulates IL-8 expression in an NF-kappaB independent manner . Positive_regulation IL8 EPHB2 12609986 1085304 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL8 EPHB2 12832293 1105572 Exposure to E. coli DNA resulted in phosphorylation of ERK 1/2 MAPK and inhibitors of activity ( PD98059 , UO126 ) significantly *reduced* the evoked [IL-8] production . Positive_regulation IL8 EPHB2 14730209 1198881 A specific inhibitor of p38 MAPK ( SB203580 ) and an NF-kappaB inhibitor ( pyrrolidine dithiocarbamate ) , but not an inhibitor ( PD 98059 ) , significantly *inhibited* neutrophil elastase induced [IL-8] release and mRNA expression . Positive_regulation IL8 EPHB2 14984736 1214718 The and p38 MAPKs can also *stimulate* the expression of both cyclooxygenase-2 (Cox-2) and [interleukin-8 (IL-8)] . Positive_regulation IL8 EPHB2 15047831 1225125 Adenovirus type 7 induces [interleukin-8] in a lung slice model and *requires* activation of . Positive_regulation IL8 EPHB2 15724247 1376873 SAA dependent [IL-8] gene expression *required* activation of the MAPK , p38 and JNK in HT-29 cells . Positive_regulation IL8 EPHB2 15731050 1377568 In contrast , inhibition of JNK and/or *resulted* in substantially less [IL-8] secretion from infected cells , independent of TLR2 or TLR5 expression . Positive_regulation IL8 EPHB2 16005185 1452948 VEGF and TIMP-2 expression in PC3 cells are dependent on AKT activation and activation in LNCaP and LNCaP C4-2B cells *leads* to IL-6 or [IL-8] secretion . Positive_regulation IL8 EPHB2 16373669 1539791 Zn2+ induced [IL-8] expression *involves* AP-1 , JNK , and activities in human airway epithelial cells . Positive_regulation IL8 EPHB2 16436136 1516417 Using various selective inhibitors for signaling molecules , we found that the inductions of [IL-8] , MCP-1 , and I-309 were *mediated* by either SCF activated or TNF-alpha activated p38 MAPK , while the induction of IP-10 by TNF-alpha was mediated by both activated p38 MAPK and NF-kappaB . Positive_regulation IL8 EPHB2 16530725 1536435 Inhibitors of either extracellular signal regulating kinase ( ERK ) or phosphatidylinositol 3-kinase (PI3K) partly reversed the thrombin induced cytokine expression , suggesting that both and PI3K kinase pathways may be *involved* in [IL-8] and VEGF expression . Positive_regulation IL8 EPHB2 16846747 1592271 We previously established that stimulation by IGF-I of [interleukin (IL)-8] expression in leukocytes *required* activation of and basal activity of c-Jun N-terminal kinase (JNK) . Positive_regulation IL8 EPHB2 17306937 1705228 Pharmacological inhibitors of and p38 but not JNK partly *inhibited* S1-P induction of [IL-8] mRNA levels . Positive_regulation IL8 EPHB2 17460254 1731571 The MMC related [IL-8] and MCP-1 expression was *inhibited* by both a p38 inhibitor ( SB203580 ) and an inhibitor ( PD98059 ) . Positive_regulation IL8 EPHB2 17517062 1791887 At acidic pH H. pylori *induced* augmentation of [IL-8] production involved markedly upregulated the NF-kappaB pathways and the -- > c-Fos -- > AP-1 pathways . Positive_regulation IL8 EPHB2 17761353 1790151 HPE induced [IL-8] expression was *inhibited* by a selective inhibitor of JNK/SAPK , but not by inhibitors of p38 kinase or . Positive_regulation IL8 EPHB2 17893134 1823894 We concluded that [IL-8] induced during infection of epithelial cells is *dependent* on continual activation of by C. trachomatis . Positive_regulation IL8 EPHB2 17941093 1849361 [IL-8] release was *mediated* by and p38 mitogen activated protein kinase (MAPK) and inhibited by mesalamine , but not hydrocortisone , at therapeutic concentrations . Positive_regulation IL8 EPHB2 18310510 1904165 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL8 EPHB2 18403779 1944236 The extracellular signal regulated kinase ( ) mitogen activated protein kinase inhibitor also *blocked* [IL-8] release , implicating Erk as a key mediator of EGFR signaling . Positive_regulation IL8 EPHB2 18442745 1900622 Furthermore , inhibition of the , p38 , and NF-kappaB pathways *blocked* SNP induced [IL-8] secretion . Positive_regulation IL8 EPHB2 18640260 1947674 In accordance , the release of [IL-8] was *attenuated* by inhibitors of the and JNK-pathways . Positive_regulation IL8 EPHB2 19756962 2195452 IL-33 scarcely affected the growth and tube formation of the endothelial cells , but *induced* IL-6 and [IL-8] secretion from endothelial cells with the rapid activation of extracellular signal regulated kinase ( ) 1/2 , so IL-33 is supposed to involve in inflammatory reaction of vascular endothelial cells through its receptor , ST2L . Positive_regulation IL8 EPHB2 20007577 2174937 Pharmacological inhibition of p38 and activity significantly *reduced* [IL-8] production in response to H. pylori , further emphasizing the importance of MAPKs in innate immune responses to the pathogen . Positive_regulation IL8 EPHB2 20107167 2258753 The zymosan induced release of IL-6 and [IL-8] was *attenuated* by inhibitors of , p38 , JNK , and NF-kappaB signaling . Positive_regulation IL8 EPHB2 20138154 2227171 Hirsutenone , dexamethasone , inhibitor or Bay 11-7085 ( an inhibitor of NF-kappaB activation ) *reduced* the lipopolysaccharide induced production of cytokines IL-1beta and [IL-8] , and the chemokine CCL17 . Positive_regulation IL8 EPHB2 20307528 2244592 Using the inhibitors of the MAP kinases and NFkappaB , it was revealed that p38 , JNK and , as well as NFkappaB , are all *involved* in LPS induced [IL-8] secretion ; Positive_regulation IL8 EPHB2 20460732 2262910 However , PD98059 ( a MEK1/2 inhibitor ) dramatically down-regulated this cytokine , suggesting *dependent* [IL-8] production . Positive_regulation IL8 EPHB2 20591071 2285894 Through ERK inhibitor ( U0126 ) and NF-kB inhibitor ( caffeine acid phenethyl ester ) treatment , it was proven that and NF-kB *regulated* chitinase induced [IL-8] expression . Positive_regulation IL8 EPHB2 20926795 2343341 p38 MAPK was required for the IL-33 mediated responses of endothelial cells , whereas was *required* for IL-33 mediated [IL-8] production by epithelial cells . Positive_regulation IL8 EPHB2 22233535 2564013 The IL-33 induced production of [IL-8] and GM-CSF from HNECs in vitro was significantly *suppressed* by corticosteroid treatment and distinct signal transduction inhibitors of , p38 MAPK , JNK , NF-?B and epidermal growth factor receptor . Positive_regulation IL8 EPHB2 22411631 2630608 The specific mitogen activated protein kinase inhibitor , U0126 , *blocks* N. fowleri mediated AP-1 activation and subsequent [IL-8] induction . Positive_regulation IL8 EPHB2 22411631 2630627 N. fowleri induced [IL-8] expression *requires* activation of in human astroglial cells . Positive_regulation IL8 EPHB2 23779254 2807689 The pharmacologic inhibitors of , U0126 and PD98059 , effectively *reduced* [IL-8] expression and the active forms of ERK signaling molecules , as detected by anti phosphorylated p44/42 antibody . Positive_regulation IL8 EPHB2 24647471 2925841 Additionally , we reveal that S1P induced [IL-8] secretion is p38 MAPK and *dependent* and that these key phosphoproteins act on the downstream effector mitogen- and stress activated kinase 1 ( MSK1 ) to control secretion of the neutrophil chemoattractant cytokine IL-8 . Positive_regulation IL8 F2R 11468165 840838 In addition , SB203580 decreased [IL-8] and MCP-1 production *induced* by the agonist peptide ( TRAP ) , suggesting functional links between the thrombin G protein coupled receptor and the p38 MAPK pathway . Positive_regulation IL8 F2R 11907122 923289 , PAR-2 , or PAR-4 , in combination , caused additive IL-6 release , but only the PAR-1 and PAR-2 combination *resulted* in an additive [IL-8] response . Positive_regulation IL8 F2R 12506061 1038282 HCE-T expression of cytokines ( IL-6 , [IL-8] , and TNFalpha ) in *response* to activation of and -2 was measured by quantitative RT-PCR and ELISA . Positive_regulation IL8 F2R 14719142 1197735 mediated signaling *stimulated* PKC and NF-kappaB dependent IL-6 and [IL-8] gene expression via phosphoinositide 3-kinase and further downstream via p42/44 and p38 MAPKs . Positive_regulation IL8 F2R 14719142 1197737 Thus , *mediated* [IL-6/IL-8] gene expression is uncoupled from Sp1 inhibition and may support proinflammatory pathomechanisms probably involved in hemorrhage/HCMV retinitis progression . Positive_regulation IL8 F2R 16697690 1563822 It was found that HDFs express and PAR-3 , and thrombin *induces* approximately 7.4-fold increase in [IL-8] secretion from HDFs . Positive_regulation IL8 F2R 18657231 2175653 Target-specific siRNA induced PAR-1 knockdown , and fully inhibited *induced* [IL-8] synthesis . Positive_regulation IL8 F2R 18657231 2175655 In conclusion , activation *induces* [IL-8] synthesis by late EPC . Positive_regulation IL8 F2R 19622587 2185668 As such , , endostatin ( ES ) and [interleukin-8 (IL-8)] *mediate* the regulation of early-onset angiogenesis and in turn impact the process of tumor-growth and disease progression . Positive_regulation IL8 F2R 20570895 2290457 We found that activation *induces* the secretion of several angiogenic factors from ovarian carcinoma cells , most prominently [interleukin (IL)-8] , growth regulated oncogene-alpha ( GRO-alpha ) , and monocyte chemoattractant protein-1 . Positive_regulation IL8 F2R 21760880 2456292 Through the use of PAR-1 and PAR-2 neutralizing antibodies , it was determined that is *essential* for GrK induced IL-6 , [IL-8] and MCP-1 release . Positive_regulation IL8 F2R 23352962 2754151 MAb 8E8 or agonist peptide *stimulated* IL-6 and [IL-8] production and VCAM-1 expression in HPMEC-ST1.6R cells . Positive_regulation IL8 F2R 8707354 371197 These results strongly suggest that catalytic activation of by thrombin *results* in PKC dependent [IL-8] production accompanied by an increase in IL-8 mRNA level . Positive_regulation IL8 F3 21472232 2361559 VIIa *regulates* [interleukin-8] , tissue factor and caspase-7 expression in SW620 cells through protease activated receptor-2 activation . Positive_regulation IL8 F3 7635444 317291 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL8 FAS 11500086 846949 TNF and *promote* [IL-8] gene transactivation via independent elements in colon carcinoma cells . Positive_regulation IL8 FAS 11500086 846950 While the IL-8 promotor elements activated by TNF are well characterised , those responsible for *induction* of [IL-8] by are unknown . Positive_regulation IL8 FAS 11500086 846951 We examined the pathway for *induced* [IL-8] secretion using two luciferase reporter constructs ; Positive_regulation IL8 FAS 11500086 846954 Nevertheless , [IL-8] *induction* by resulted primarily from increased transcription and not from an increase in IL-8 mRNA stability . Positive_regulation IL8 FAS 11500086 846955 These results suggest that promoter elements/enhancers involved in *mediated* [IL-8] induction are distinct from those used by TNF and not contained within the 1.6 kb region immediately upstream of the initiation codon . Positive_regulation IL8 FAS 11595074 870104 IFN-gamma pretreatment and Ag stimulation synergistically *induced* not only apoptosis but also [IL-8] and MCP-1 secretion . Positive_regulation IL8 FAS 12402381 1009527 Conclusively , TGF-beta2 , [IL-8] and MCP-1 were overexpressed in HBV associated hepatoma cells , and the expressions of chemokines were not *increased* by ligation in human hepatoma cells . Positive_regulation IL8 FAS 12485855 1025134 Activation of the p38 MAPK and ERK1/2 pathways is required for *induced* [IL-8] production in colonic epithelial cells . Positive_regulation IL8 FAS 12485855 1025135 This paper aims to examine the contribution of all three of the MAP kinase signaling pathways to *induced* [IL-8] up-regulation in HT29 colon epithelial cells . Positive_regulation IL8 FAS 12629330 1067355 Fas neutralizing agent ( Fas-Fc ) suppressed the *mediated* secretions of [IL-8] and MCP-1 ( P < 0.01 ) both as well as the Fas mediated apoptosis . Positive_regulation IL8 FAS 12629330 1067357 On the other hand , whereas Z-IETD-FMK suppressed apoptosis , the inhibitor enhanced the *mediated* secretions of both [IL-8] and MCP-1 beyond the value of the Fas stimulation alone ( P < 0.01 ) , suggesting an enhanced signalling for the chemokine expression . Positive_regulation IL8 FAS 15831231 1394443 In addition to hypoxia/anoxia stimulation , increased [IL-8] in gliomas occurs in *response* to ligation , death receptor activation , cytosolic Ca ( 2+ ) , TNF-alpha , IL-1 , and other cytokines and various cellular stresses . Positive_regulation IL8 FAS 16955241 1611102 Both and A23187 *caused* significant [IL-8] expression and cell death in A549 cells . Positive_regulation IL8 FAS 17447415 1665565 Moreover , *triggered* expression of IL-4 and [IL-8] when caspase activity was inhibited , but not in the absence of ZVAD . Positive_regulation IL8 FAS 19855073 2156419 Taken together , the production of [IL-8] by SPE B in A549 cells is *mediated* by , and followed by the activation of FADD , caspase 8 , MEKK1 , ERK and NF-kappaB . Positive_regulation IL8 FAS 23434371 2760124 *induced* production of MCP-1 and [IL-8] promoted chemotaxis of phagocytes toward apoptotic cells , suggesting that these factors serve as `` find-me '' signals in this context . Positive_regulation IL8 FAS 23967134 2832635 E3330 treatment prevented the functional activation of NF-?B via the alteration of APE1 subcellular trafficking and reduced IL-6 and [IL-8] expression *induced* by TNF-a and accumulation through blockage of the redox mediated activation of NF-?B . Positive_regulation IL8 FAS 7594569 325863 The experiments presented here demonstrate that Ag ligation alone *led* to production of [IL-8] by colonic epithelial cells and represented another function mediated by Fas Ag in addition to apoptosis . Positive_regulation IL8 FAS 7594569 325865 This study shows that the pathways leading to cell death and [IL-8] production in *response* to Ag ligation and TNF-alpha were similar with regard to their requirements for new gene expression , protein synthesis , and protein kinase activity . Positive_regulation IL8 FAS 8912630 395406 mediated stimulation *induces* [IL-8] secretion by rheumatoid arthritis synoviocytes independently of CPP32 mediated apoptosis . Positive_regulation IL8 FAS 8912630 395413 We also demonstrated that stimulation of RA synoviocytes *leads* to [IL-8] secretion independently of the CPP32 mediated apoptosis , which would accelerate inflammation . Positive_regulation IL8 FOXO1 23204226 2736357 These effects were associated with *mediated* inhibition of transcription of the antiapoptosis gene survivin ( BIRC5 ) and the CSC associated cytokine [interleukin-8] . Positive_regulation IL8 GPR115 11590141 882756 Constitutive activation of NF-kappa B and secretion of [interleukin-8] *induced* by the of Kaposi 's sarcoma associated herpesvirus involve G alpha(13) and RhoA . Positive_regulation IL8 GPR115 16690053 1563667 The chymase induced IL-8 release was inhibited by pertussis toxin as well as U0126 ( an inhibitor for extracellular signal regulated kinase pathway ) and SB203580 ( p38 inhibitor ) , suggesting that the chymase induced [IL-8] production is *mediated* by and mitogen activated protein kinases . Positive_regulation IL8 GPR132 11590141 882745 Constitutive activation of NF-kappa B and secretion of [interleukin-8] *induced* by the of Kaposi 's sarcoma associated herpesvirus involve G alpha(13) and RhoA . Positive_regulation IL8 GPR132 16690053 1563656 The chymase induced IL-8 release was inhibited by pertussis toxin as well as U0126 ( an inhibitor for extracellular signal regulated kinase pathway ) and SB203580 ( p38 inhibitor ) , suggesting that the chymase induced [IL-8] production is *mediated* by and mitogen activated protein kinases . Positive_regulation IL8 GPR132 19063986 2127659 In human epidermal keratinocytes , *mediates* the secretion of cytokines including [interleukin-6 and -8] , and blocks cell cycle progression at the G1 phase in response to ligands . Positive_regulation IL8 GPR87 11590141 882825 Constitutive activation of NF-kappa B and secretion of [interleukin-8] *induced* by the of Kaposi 's sarcoma associated herpesvirus involve G alpha(13) and RhoA . Positive_regulation IL8 GPR87 16690053 1563736 The chymase induced IL-8 release was inhibited by pertussis toxin as well as U0126 ( an inhibitor for extracellular signal regulated kinase pathway ) and SB203580 ( p38 inhibitor ) , suggesting that the chymase induced [IL-8] production is *mediated* by and mitogen activated protein kinases . Positive_regulation IL8 HBEGF 20889674 2353416 LTD4 induces *dependent* [CXCL8] release through EGFR activation in human bronchial epithelial cells . Positive_regulation IL8 HRH1 16491014 1541266 *stimulated* [interleukin 8] and granulocyte macrophage colony stimulating factor production by bronchial epithelial cells requires extracellular signal regulated kinase signaling via protein kinase C . Positive_regulation IL8 IL1B 10063910 593325 N-Acetylcysteine (NAC) or dimethylsulfoxide inhibited [IL-8] expression *induced* by tumor necrosis factor-alpha (TNF-alpha) or . Positive_regulation IL8 IL1B 10201981 605774 Surprisingly , *mediated* [IL-8] gene expression was also inhibited in HT-29 cells as measured by Northern blot and ELISA . Positive_regulation IL8 IL1B 10226066 610334 Release of in the airway microenvironment *induces* the production of proinflammatory factors from parenchymal airway cells , including [IL-8] . Positive_regulation IL8 IL1B 10353264 617599 Up-regulation of *stimulated* [interleukin-8] in human keratinocytes by nitric oxide . Positive_regulation IL8 IL1B 10353264 617600 Despite small variations in the response to NO by the three cell types , these results demonstrate that NO can up-regulate *stimulated* [IL-8] expression in human keratinocytes . Positive_regulation IL8 IL1B 10372996 622126 It has been shown in this and other laboratories that and tumor necrosis factor-alpha (TNF-alpha) are potent *inducers* of HRPE [IL-8] and MCP-1 secretion . Positive_regulation IL8 IL1B 10372996 622137 and TNF-alpha *induced* dose dependent increases in HRPE [IL-8] and MCP-1 secretion with maximal stimulation observed at 2-5 ng/ml . IL-4 alone ( 100 ng/ml ) resulted in a slight increase of MCP-1 and IL-8 secretion . Positive_regulation IL8 IL1B 10372996 622142 HRPE [IL-8] and MCP-1 gene expression and protein production are *stimulated* by or TNF-alpha through pathways differentially modulated by IL-4 and GM-CSF . Positive_regulation IL8 IL1B 10559516 566646 However , *induced* productions of both MCP-1 and [IL-8] were dose-dependently suppressed by enrichment of cells with vitamin E. Vitamin E , at the doses used , did not significantly change the spontaneous production but dose-dependently inhibited the IL-1beta induced production of inflammatory cytokine IL-6 . Positive_regulation IL8 IL1B 10580798 570123 However , 100 u/ml *induced* greater stimulation of both [IL-8] and MCP-1 secretion in HCEC ( 50 and 20 times above controls , respectively ) than in FHAS ( three and two times above controls , respectively ) . Positive_regulation IL8 IL1B 10584410 570973 Stimulation of epithelial cells with IFN-gamma +TNF-alpha <+IL-1 beta> significantly *increased* [IL-8] release and neutrophil adherence . Positive_regulation IL8 IL1B 10584410 570976 The spontaneous or IFN-gamma +TNF-alpha <+IL-1 beta> *induced* [IL-8] release was significantly augmented after the addition of neutrophils . Positive_regulation IL8 IL1B 10619828 657345 In addition , tumor necrosis factor-alpha (TNF-alpha) plus plus interferon-gamma (IFN-gamma) *increased* [IL-8] in culture supernatant of epithelial cells ; Positive_regulation IL8 IL1B 10620700 657692 We examined the role of p38 mitogen activated protein (MAP) kinase in the tumor necrosis factor alpha (TNF-alpha)- or *induced* production of interleukin-6 (IL-6) and [interleukin-8 (IL-8)] in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Positive_regulation IL8 IL1B 10641976 660756 Both and NE *led* to a significant increase in [IL-8] : 12.8 +/- 2.8 ng/ml and 0.8 +/- 0.3 ng/ml , respectively . Positive_regulation IL8 IL1B 10677576 668275 We then investigated the effects of transfection of monocytes with these oligonucleotides on *stimulated* [IL-8] production , IL-8 mRNA expression , and NF-kappaB binding activity . Positive_regulation IL8 IL1B 10679106 668790 Lipoxin A4 inhibits *induced* IL-6 , [IL-8] , and matrix metalloproteinase-3 production in human synovial fibroblasts and enhances synthesis of tissue inhibitors of metalloproteinases . Positive_regulation IL8 IL1B 10681439 669147 Although *induced* [IL-8] synthesis was augmented 3-fold by IL-18 , IL-18 suppressed IL-1beta induced PGE ( 2 ) production by 40 % . Positive_regulation IL8 IL1B 10707928 673450 and tumor necrosis factor (TNF)-alpha both induced a marked *increase* in C3 and [IL-8] secretion . Positive_regulation IL8 IL1B 10728932 579488 alone or a combination of TNF-alpha and IL-1beta comparably *increased* IL-6 and [IL-8] mRNA levels slightly . Positive_regulation IL8 IL1B 10732314 678308 U46619 augmented *stimulated* IL-6 and [IL-8] mRNA expression within 2 hours of treatment . Positive_regulation IL8 IL1B 10741905 680030 Both IL-1alpha and *induced* ICAM-1 expression and [IL-8] and MCP-1 production at lower doses than TNF alpha or TNF beta . Positive_regulation IL8 IL1B 10867834 706497 When cells were preincubated with 10 ( -4 ) M CAM for 7 days , the *induced* secretion of [IL-8] decreased significantly . Positive_regulation IL8 IL1B 10881930 709226 The addition of and tumor necrosis factor (TNF)-alpha strongly *enhanced* [IL-8] , MCP-1 , and RANTES secretion ; Positive_regulation IL8 IL1B 10958731 726185 In vitro studies demonstrated that SK-N-MC and SK-N-SH cells express low levels of [IL-8] under normal conditions and that and tumor necrosis factor-alpha significantly *increased* expression of IL-8 at 24 and 48 hours . Positive_regulation IL8 IL1B 11053499 745207 The addition of MCFA ( 5 mmol/L ) induced a 40 % increase in *induced* [IL-8] secretion and a 35 % increase in tumor necrosis factor (TNF)-alpha induced IL-8 secretion , respectively . Positive_regulation IL8 IL1B 11053499 745209 The addition of LCFA ( 5 mmol/L ) induced a 140 % increase in *induced* [IL-8] secretion and a 110 % increase in TNF-alpha induced IL-8 secretion , respectively . Positive_regulation IL8 IL1B 11064286 746872 Secretion of IL-1alpha was dose- and time dependent , with a maximal level of 600 pg/ml detectable upon 2-h stimulation with 20 microg of LPS per ml . IL-1ra and the neutralizing antibody significantly blocked the ability of to *stimulate* secretion of [IL-8] by MAC-T cells . Positive_regulation IL8 IL1B 11069732 747853 As expected , highly *stimulated* NO , IL-6 , [IL-8] , IL-10 , IL-1ra , PGE ( 2 ) and stromelysin synthesis , but dramatically decreased PG production . Positive_regulation IL8 IL1B 11125305 762813 TNF-alpha increased both IL-8 mRNA expression and protein production , whereas slightly *increased* [IL-8] release but did not change mRNA expression in AEC-II . Positive_regulation IL8 IL1B 11159726 781264 3. The cyclic AMP elevating agents , dibutyryl cyclic AMP ( approximately EC ( 50 ) 135 microM ) , forskolin ( approximately EC ( 50 ) 530 nM ) and cholera toxin ( approximately EC ( 50 ) 575 pg ml(-1) ) abolished *induced* release of GM-CSF , RANTES and eotaxin , but not [IL-8] . Positive_regulation IL8 IL1B 11238519 790731 In adipose tissue fragments , IL-1beta ( 3 nM ) and tumor necrosis factor alpha ( 0.6 nM ) were able to stimulate IL-8 production by 12-fold and 5-fold , respectively ( P < 0.001 ) , when incubated for 48 h. Incubations with isolated adipocytes were performed up to 6 h , and and tumor necrosis factor alpha significantly *increased* [IL-8] production by 50-60 % ( P < 0.05 ) . Positive_regulation IL8 IL1B 11285034 799726 Further , the treatment of endometrial carcinoma cells with inflammatory cytokines , IL-1beta and tumor necrosis factor-alpha (TNF-alpha) , demonstrated that and TNF-alpha *induced* [IL-8] expression in endometrial cancer cells . Positive_regulation IL8 IL1B 11285034 799727 was a more potent *inducer* of [IL-8] expression than TNF-alpha in our studies . Positive_regulation IL8 IL1B 11339502 812220 TGF-beta did not significantly affect constitutive interleukin (IL)-8 secretion or *induced* [IL-8] secretion from suspended cells . Positive_regulation IL8 IL1B 11339502 812221 In contrast , TGF-beta stimulated IL-8 secretion as well as augmented *induced* [IL-8] secretion from adherent cells . Positive_regulation IL8 IL1B 11381071 820593 IL-4 also enhanced *induced* HRPE [IL-8] . Positive_regulation IL8 IL1B 11437211 832738 TENS inhibits *induced* synthesis of IL-1beta , IL-6 , and [IL-8] by inhibiting their mRNA expression , and thus significantly suppresses the amplification of IL-1beta induced inflammatory responses in PDL cells . Positive_regulation IL8 IL1B 11446462 835394 Regulatory *role* of in the expression of IL-6 and [IL-8] in human corneal epithelial cells during Pseudomonas aeruginosa colonization . Positive_regulation IL8 IL1B 11555581 859956 The inflammatory cytokine *up-regulated* [IL-8] expression in a time- and concentration dependent manner in KS cell lines . Positive_regulation IL8 IL1B 11717194 881915 Ligation of adenosine receptors by adenosine or its related analogue , 2-chloroadenosine ( 2-CADO ) , N ( 6 ) -cyclopentyladenosine (CPA) or CGS21680 synergistically increased *induced* IL-6 and [IL-8] production . Positive_regulation IL8 IL1B 11767276 890360 We aimed to : 1 ) characterize the expression of interleukin (IL)- Ialpha and IL-Ibeta in human gingiva and cultured GEC : 2 ) demonstrate the ability of A. actinomycetemcomitans extracts to upregulate IL-1alpha , IL-1beta and IL-8 expression in GEC in vitro : and 3 ) characterize the *role* of IL-1alpha and in the induction of [IL-8] expression in GEC in vitro . Positive_regulation IL8 IL1B 11767276 890364 although they inhibited [IL-8] *induced* by IL-1alpha or . Positive_regulation IL8 IL1B 11910356 924164 Toxin A did not increase IL-8 levels in EB-treated cells , whereas [IL-8] release in *response* to was not affected . Positive_regulation IL8 IL1B 11911801 924218 In addition , the specificity of this inhibition was demonstrated by the inability of herbimycin-A to block in a significant manner *induction* of [CXCL-8] . Positive_regulation IL8 IL1B 11936905 927960 and TNF-alpha *stimulated* the secretion of [IL-8] in HT29-MTX goblet cells . Positive_regulation IL8 IL1B 11950021 930276 No NSAID showed significant effects on basal and *stimulated* [IL-8] production , except CELE and IBUP , which slightly increased basal IL-8 production . Positive_regulation IL8 IL1B 11989790 936372 Our results show that pleural fluid isolated human fibroblasts release [IL-8] and MCP-1 upon *stimulation* with , TNF-alpha , and LPS in both a concentration- and time dependent manner . Positive_regulation IL8 IL1B 11989790 936376 *induced* the maximum release of [IL-8] ( 800-fold ) and MCP-1 ( 164-fold ) , as compared to the controls . Positive_regulation IL8 IL1B 12011471 941474 CRH was biologically active on human sebocytes : it induced biphasic increase in synthesis of sebaceous lipids with a maximum stimulation at 10 ( -7 ) M and up-regulated mRNA levels of 3 beta- hydroxysteroid dehydrogenase/Delta ( 5-4 ) isomerase , although it did not affect cell viability , cell proliferation , or *induced* [IL-8] release . Positive_regulation IL8 IL1B 12022438 943269 1 alpha,25-dihydroxyvitamin D3 suppresses *induced* [interleukin-8] production in human whole blood : an involvement of erythrocytes in the inhibition . Positive_regulation IL8 IL1B 12022438 943271 Although monocytes were found to be mainly responsible for *induced* [IL-8] production in whole blood , 1,25 ( OH ) 2D3 inhibited IL-8 production by isolated mononuclear cells only marginally . Positive_regulation IL8 IL1B 12034025 948186 Addition of capsaicin ( 8-methyl-N-vanillyl-6-nonenamide ) , a known inhibitor of NF-kappaB , resulted in the inhibition of constitutive as well as *induced* and TNF-alpha induced [IL-8] expression in melanoma cells . Positive_regulation IL8 IL1B 12045890 895170 The *role* of in the regulation of [IL-8] and IL-6 in human corneal epithelial cells during Pseudomonas aeruginosa colonization . Positive_regulation IL8 IL1B 12045890 895174 The purpose of this study was to investigate whether *regulates* the expression of IL-6 and [IL-8] in human corneal epithelial cells during Pseudomonas aeruginosa colonization . Positive_regulation IL8 IL1B 12089685 959743 *stimulates* [interleukin-8] production and gene expression in synovial cells from human temporomandibular joint . Positive_regulation IL8 IL1B 12089685 959745 Furthermore , *enhanced* [IL-8] production in HTS cells in a time- and dose dependent manner and stimulated IL-8 gene expression . Positive_regulation IL8 IL1B 12089685 959746 In addition , we found that *stimulated* [IL-8] production through an increase in IL-8 gene expression in HTS cells , which may be associated with the increase of infiltrating inflammatory cells seen in the synovial membrane of TMJ disorders . Positive_regulation IL8 IL1B 12126643 966019 Role of P38 MAPK , AP-1 , and NF-kappaB in *induced* [IL-8] expression in human vascular smooth muscle cells . Positive_regulation IL8 IL1B 12126643 966039 Our data demonstrate that AP-1 and NF-kappaB are essential transcription factors for *induced* [IL-8] gene expression in hVSMCs . Positive_regulation IL8 IL1B 12165085 972744 IL-6 and [IL-8] production was *stimulated* by recombinant human ( hIL-1beta ) or human tumour necrosis factor-alpha ( hTNF-alpha ) alone in a dose dependent manner . Positive_regulation IL8 IL1B 12379764 997316 GROalpha does not seem to initiate TNFalpha , IL-1beta , and [IL-8] in an early phase , but *induces* and IL-8 in a late phase . Positive_regulation IL8 IL1B 12406856 1031643 and CSM *increased* [IL-8] and GM-CSF release by macrophages from both smokers and patients with COPD . Positive_regulation IL8 IL1B 12424420 1014183 The *induced* [IL-6/IL-8] release of HPMC from healthy donors and from patients with end-stage renal disease ( ESRD ) were measured before the start of chronic peritoneal dialysis ( PD ) and during PD therapy . Positive_regulation IL8 IL1B 12505195 1037856 In the present paper we investigated the effect of pharmacological inhibition of NF-kappaB with pyrrolidinedithiocarbamate ( PDTC ) on *induced* [IL-8] production by the human intestinal epithelial cell line HT-29 . Positive_regulation IL8 IL1B 12507564 1038409 The results indicate a primary role for IL-8 in the recruitment of neutrophils into the gland , and suggest that and TNF-alpha are not *necessary* for [IL-8] production and release in response to endotoxin . Positive_regulation IL8 IL1B 12507912 1038461 Compared to non-CF cells , CF bronchial epithelial cells were characterized by a higher susceptibility to produce elevated [IL-8] and RANTES production in an hypertonic NaCl milieu in *response* to activation . Positive_regulation IL8 IL1B 12519386 1047729 Pointing to the potentially underlying mechanism of increased *stimulated* [IL-8] secretion in HT-29 cells , butyrate up-regulated IL-1RI mRNA but not IL-1RII . Positive_regulation IL8 IL1B 12519386 1047730 Pharmacological inhibition of protein tyrosine phosphatases or treatment with mesalamine or sulphasalazine diminished *stimulated* [IL-8] secretion by butyrate exposed HT-29 cells substantially . Positive_regulation IL8 IL1B 12524080 1047848 [Interleukin 8] *induced* by via activation of NF-kappaB in granulosa cells may have a role in the periovulatory period of follicular maturation . Positive_regulation IL8 IL1B 12548226 1051364 Dexamethasone and interleukin-10 treatment significantly reduced *induced* uterine contractility ( P < .05 ) and amniotic fluid prostaglandins ( P < .05 ) but not [interleukin-8] or interleukin-1 receptor antagonist . Positive_regulation IL8 IL1B 12550108 1028896 Moreover , IFN-gamma reduced *stimulated* [IL-8] production but significantly increased both MCP-1 and RANTES . Positive_regulation IL8 IL1B 12595589 1061694 *stimulated* [IL-8] secretion was inhibited 25 % by TGF-beta1 in Caco2 cells and in H4 cells was inhibited by TGF-beta1 , Epo , and TGF-beta2 . Positive_regulation IL8 IL1B 12667212 1075404 The p38 mitogen activated protein kinase regulates *induced* [IL-8] expression via an effect on the IL-8 promoter in intestinal epithelial cells . Positive_regulation IL8 IL1B 12672669 1099640 In LSF cells , significantly *increased* [IL-8] and PGE2 synthesis and COX-2 and IL-8 mRNA expression , but progesterone significantly attenuated these effects . Positive_regulation IL8 IL1B 12672669 1099642 In prelabor amnion cells , also *increased* [IL-8] and PGE2 synthesis and both COX-2 and IL-8 mRNA and promoter expression ; Positive_regulation IL8 IL1B 12672669 1099645 In postlabor amnion cells , *increased* [IL-8] and PGE2 synthesis and COX-2 expression , but progesterone did not attenuate the effect of IL-1beta upon IL-8 synthesis . Positive_regulation IL8 IL1B 12688521 1030515 After addition of to MKN45 cells , a gastric cancer cell line , or human umbilical vein endothelial cells ( HUVECs ) , [IL-8] production was *detected* in supernatants . Positive_regulation IL8 IL1B 12706459 1082646 In the present study , we determined that Caco-2 cells express the kappa-opioid receptor and its activation by trans- ( +/- ) -3,4-dichloro-N-methyl-N [ 2- ( 1-pyrolidinyl ) cyclohexyl ] benzeneacetamide methanesulfonate ( U-50488 ) leads to decreased [interleukin-8] secretion in the *presence* of . Positive_regulation IL8 IL1B 12727980 1086550 Whereas *increased* the production of IL-6 , [IL-8] , and monocyte chemotactic protein-1 , and expression of cyclooxygenase-2 mRNA in ESC cultured without treatment , the stimulatory effects of IL-1 beta were reduced in the decidualized cells . Positive_regulation IL8 IL1B 12748056 1140863 Tumor necrosis factor-alpha , , and lipopolysaccharide *stimulated* [IL-8] production from epithelial cells in a dose- and time dependent manner , and these effects were abrogated by specific antibodies or inhibitors . Positive_regulation IL8 IL1B 12753503 1090315 Tumour necrosis factor-alpha (TNF-alpha) and *induced* mesothelial cell [IL-8] mRNA expression , and neutralizing anti-TNF-alpha antibody and IL-1 receptor antagonist nearly completely obliterated CoMTB induced mesothelial cell IL-8 mRNA expression and protein secretion . Positive_regulation IL8 IL1B 12755375 1090496 LPS and *stimulated* IL-1beta , IL-6 , [IL-8] , iNOS and COX-2 gene expression . Positive_regulation IL8 IL1B 12781209 1095636 This study determined myrrh oil ( MO ) cytotoxicity to human gingival fibroblasts and epithelial cells and its effect , measured by ELISA , on *stimulated* IL-6 and [IL-8] production . Positive_regulation IL8 IL1B 12781209 1095638 There was little or no detectable *stimulated* production of IL-6 or [IL-8] by cells exposed to > /=0.0025 % MO , probably reflective of loss of viability . Positive_regulation IL8 IL1B 12781209 1095640 At subtoxic MO levels ( 0.00001-0.001 % ) , there was a significant reduction of *stimulated* IL-6 and [IL-8] production by fibroblasts , but not by epithelial cells . Positive_regulation IL8 IL1B 12792762 1097870 Conversely , IL-1alpha and , induced a 5- to 104-fold stimulation of BEC and a 330 to 1,138-fold *increase* in [IL-8] expression in estrogen independent BCC . Positive_regulation IL8 IL1B 12797546 1098723 IL-8 release from fibroblasts was significantly increased when cultured with RBC or RBC-CM and both tumor necrosis factor-alpha (TNF-alpha) and further *stimulated* this [IL-8] secretion . Positive_regulation IL8 IL1B 12824917 1104406 Exogenous *enhanced* expression of various cytokines ( IL-6 , [IL-8] , and vascular endothelial growth factor ( VEGF ) ) and intracellular adhesion molecule-1 ( ICAM-1 ) by A549 , PC14 , RERF-LC-AI , and SBC-3 cells expressing IL-1 receptors . Positive_regulation IL8 IL1B 12865660 1111900 HUVEC IL-8 induction by copper was higher than by 50 pg/mL tumor necrosis factor-alpha , whereas 50 pg/mL and 1 ng/mL platelet activating factor did not *stimulate* [IL-8] production or release . Positive_regulation IL8 IL1B 12873450 1114304 The objective of the study was to investigate the effects of baicalin , baicalein , and wogonin ( plant flavonoids ) on interleukin-6 (IL-6) and [interleukin-8 (IL-8)] protein production , mRNA expression , and nuclear factor-kappaB (NF-kappaB) binding activities *induced* by in human retinal pigment epithelial cell line ( ARPE-19 ) cells . Positive_regulation IL8 IL1B 12873450 1114329 IL-6 and [IL-8] in the culture media of ARPE-19 cells were *increased* by in a dose dependent manner . Positive_regulation IL8 IL1B 12873450 1114331 Baicalin did not suppress *induced* IL-6 and [IL-8] production , but dexamethasone , baicalein , and wogonin , significantly suppressed IL-6 and IL-8 production . Positive_regulation IL8 IL1B 12880609 1115758 stimulation *increased* IL-6 and [IL-8] , but did not affect IL-4 and IL-10 production . Positive_regulation IL8 IL1B 12897563 1118471 The expression of both [IL-8] protein and messenger RNA in adenoidal fibroblasts was *enhanced* by Haemophilus influenzae endotoxin and and was positively correlated with increases in NF-kappa B activity . Positive_regulation IL8 IL1B 12912854 1129490 Comparable [IL-8] secretory responses ( approximately 1700 ng/ml ) measured by ELISA were *induced* by 2.0 ng/ml and by H pylori at a multiplicity of infection ( MOI ) of 50 . Positive_regulation IL8 IL1B 12948934 1185436 In response to hrHRF , these cells *induced* [IL-8] mRNA expression within 4 h. H2O2 , but not or tumor necrosis factor-alpha , stimulated secretion of HRF p23 by BEAS-2B cells , suggesting that oxidative stress may trigger the release of HRF p23 from bronchial epithelial cells . Positive_regulation IL8 IL1B 13129857 1185628 Dexamethasone ( 50 nM ) attenuated [IL-8] production by 50 % ( P < 0.05 ) , and ( 2 microg/l ) *increased* IL-8 production up to 15-fold ( P < 0.001 ) . Positive_regulation IL8 IL1B 1386759 193390 Recombinant interleukin-1 receptor antagonist blocked the interleukin-1 mRNA as well as interleukin-6 and [interleukin-8] mRNA accumulation *induced* by . Positive_regulation IL8 IL1B 14580366 1156927 15d-PGJ ( 2 ) inhibited the *induced* expression of ENA-78 , but not the expression of [IL-8] or GRO-alpha in response to IL-1 . Positive_regulation IL8 IL1B 14586044 1159421 Resveratrol reduced *stimulated* [IL-8] and GM-CSF release in both smokers and COPD patients to below basal levels . Positive_regulation IL8 IL1B 14617515 1200649 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL8 IL1B 14643170 1188212 Pre-treatment with beclomethasone , budesonide or fluticasone reduced TNFalpha- and *stimulated* [IL-8] and RANTES release from HASMC in a dose dependent manner . Positive_regulation IL8 IL1B 14670800 1210949 Constitutive or *induced* [IL-8] or IL-6 secretion or nuclear factor-kappaB activity was not significantly different between non-CF and CF cells . Positive_regulation IL8 IL1B 14967219 1209134 By enzyme linked immunosorbent assay ( ELISA ) , IL-1beta had no effect on IL-15 production from ESCs in short-term culture ( for 24 h ) , whereas *stimulated* production of [IL-8] . Positive_regulation IL8 IL1B 15001224 1217050 and TNF-alpha mRNA , but not protein , were increased , and [IL-8] secretion *increased* without an observed increase in mRNA . Positive_regulation IL8 IL1B 15028114 1243978 Lastly , in human gastric adenocarcinoma ( AGS ) cells , ML 3000 dose-dependently inhibited both baseline and *stimulated* ( 20 ng/ml ) [IL-8] secretion with IC50s of 0.46 microM and 1.1 microM respectively . Positive_regulation IL8 IL1B 15076648 1233024 Twenty-four hours after exposure to 500 microg/m3 , nasal secretion levels of increased 72.3 % ( 0-150.2 % , P=0.002 ) , levels of IL-6 increased 42.2 % ( -28-161.9 % , P=0.01 ) , and levels of [IL-8] *increased* 19.7 % ( -20.3-60.5 % , P=0.03 ; median and 95 % confidence interval ) . Positive_regulation IL8 IL1B 15086593 1237652 Both TNF-alpha and *induced* [IL-8] releases , conversely , were little affected by lafutidine up to a concentration of 10 ( -5 ) M . Positive_regulation IL8 IL1B 15100312 1239741 Moreover , when complexed with IL-6 , both isoforms specifically inhibited the *induced* secretion of [CXCL8] . Positive_regulation IL8 IL1B 15103492 1258356 There was no difference in *induced* [IL-8] production in children compared with adults . Positive_regulation IL8 IL1B 15208668 1281322 *stimulates* [IL-8] expression through MAP kinase and ROS signaling in human gastric carcinoma cells . Positive_regulation IL8 IL1B 15208668 1281324 *induced* the [IL-8] expression in a time- and concentration dependent manner . Positive_regulation IL8 IL1B 15208668 1281352 N-acetyl cysteine (NAC) prevented the *induced* ROS production and [IL-8] expression . Positive_regulation IL8 IL1B 15208668 1281353 Deletional and site directed mutagenesis studies on the IL-8 promoter revealed that activator protein-1 (AP-1) and nuclear factor (NF)-kappaB sites were required for the *induced* [IL-8] transcription . Positive_regulation IL8 IL1B 15208668 1281360 The above results suggest that MAPK-AP-1 and ROS-NF-kappaB signaling pathways are involved in the *induced* [IL-8] expression and that these paracrine signaling pathways induce endothelial cell proliferation . Positive_regulation IL8 IL1B 15229109 1301848 In this study , we show that human breast milk dramatically suppressed the *induced* activation of the [IL-8] gene promoter by inhibiting the activation pathway of NF-kappaB . Positive_regulation IL8 IL1B 1532945 183374 Significant inhibition of the *induced* [IL-8] synthesis was observed when IRAP was added 60 or 90 min after IL-1 beta ; Positive_regulation IL8 IL1B 15349048 1292335 Conjunctival epithelial cells release [interleukin-8] in *response* to and tumor necrosis factor alpha but not interferon-gamma . Positive_regulation IL8 IL1B 15383152 1304181 However , IL-6 , [IL-8] , and IL-13 production *induced* by were significantly enhanced by addition of epinephrine . Positive_regulation IL8 IL1B 15450530 1300746 At 1-10ng/ml , OSM significantly decreased *stimulated* [IL-8] , MIP-1beta , PGE ( 2 ) and *NO production but amplified IL-1beta stimulating effect on IL-6 production . Positive_regulation IL8 IL1B 15456740 1342013 However , H2O2 , tumor necrosis factor-alpha (TNF-alpha) , and significantly *increased* NF-kappaB activation and expression of [IL-8] compared with control cells . Positive_regulation IL8 IL1B 15550066 1338538 Effects of PD98059 , SB202190 and SP600125 ( inhibitors of ERK , p38 and JNK , respectively ) on *induced* secretion of IL-6 and [IL-8] , and on IL-1beta induced expression of cyclo-oxygenase-2 (COX-2) in endometriotic cells were studied . Positive_regulation IL8 IL1B 15550066 1338542 Both SB202190 and SP600125 suppressed *induced* secretion of IL-6 and [IL-8] , and PD98059 suppressed IL-1beta induced secretion of IL-8 . Positive_regulation IL8 IL1B 15618163 1357617 Expression of proinflammatory cytokines , such as interleukin-6 (IL-6) and [IL-8] , was also *induced* significantly in both cell types by the Msps , as determined by reverse transcription-PCR and an enzyme linked immunosorbent assay , whereas synthesis could be detected only in the THP-1 cells . Positive_regulation IL8 IL1B 15652448 1364226 We comprehensively investigated the involvement of mitogen activated protein kinases ( MAPKs ) /activator protein-1 (AP-1) and IkappaB kinases ( IKKs ) /IkappaBs/nuclear factor-kappaB (NF-kappaB) in *stimulated* IL-6 , [IL-8] , prostaglandin E ( 2 ) ( PGE ( 2 ) ) and matrix metalloproteinase-1 (MMP-1) production by human gingival fibroblasts (HGF) . Positive_regulation IL8 IL1B 15664665 1365302 The specific p38 mitogen activated protein kinase (MAPK) inhibitor SB 203580 reduced IL-8 production stimulated by the combination of BK and IL-1beta as well as the *stimulated* [IL-8] production . Positive_regulation IL8 IL1B 15699159 1372499 Furthermore , functional potentiation of glucocorticoid activity in hypoxia was observed as an enhancement of dexamethasone induced glucocorticoid response element promoter activity and enhanced dexamethasone mediated inhibition of *stimulated* [IL-8] expression and hypoxia induced vascular endothelial growth factor expression . Positive_regulation IL8 IL1B 15778394 1385091 Furthermore , *induced* [IL-8] , IL-6 , and matrix metalloproteinase-3 protein production was significantly inhibited in DN MKK3/DN MKK6 transfected cells . Positive_regulation IL8 IL1B 15784717 1410099 plays a key role in infection induced preterm labor and *increases* prostaglandin H synthase 2 (PGHS-2) and [IL-8] expression . Positive_regulation IL8 IL1B 15784717 1410101 In this study , we tested the hypotheses that both and mechanical stretch *increase* the myometrial expression of PGHS-2 and [IL-8] via MAPK activation and that their effects are synergistic . Positive_regulation IL8 IL1B 15828923 1394272 *induced* [IL-8] and IL-6 secretion was significantly decreased after granulocyte/monocyte adsorptive apheresis . Positive_regulation IL8 IL1B 15896421 1407981 *increased* the production of [IL-8] and IL-6 ( P < 0.01 ) . Positive_regulation IL8 IL1B 15939312 1415505 *induces* [IL-8] in bronchial cells via NF-kappaB and NF-IL6 transcription factors and can be suppressed by glucocorticoids . Positive_regulation IL8 IL1B 16095910 1448142 Inhibition of p38 MAPK led to decreased [IL-8] following *stimulation* with and/or activating peptide . Positive_regulation IL8 IL1B 16118510 1454362 *stimulated* [IL-8] and MCP-1 mRNA at 6 h . TNF-alpha stimulated IL-8 and MCP-1 mRNA expression at 1 .5 and 3 h. alpha-MSH ( 10 ( -14 ) to 10 ( -10 ) M ) inhibited IL-8 and MCP-1 mRNA expression in the cells stimulated with IL-1beta or TNF-alpha . Positive_regulation IL8 IL1B 16175346 1461827 TNF-alpha and are early regulators of the immune response and both *induce* the release of secondary cytokines , such as IL-6 and [IL-8] . Positive_regulation IL8 IL1B 16309465 1486631 also *increased* IL-8 secretion and [IL-8] mRNA expression in human neuronal cell lines ( NT2-N and SH-SY5Y ) , through p38 and ERK1/2 MAP kinase dependent pathways . Positive_regulation IL8 IL1B 16354624 1492631 *stimulated* IL-6 , [IL-8] , and MCP-1 mRNA expression and protein levels . Positive_regulation IL8 IL1B 16375968 1547165 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL8 IL1B 16391493 1560933 These findings indicate that berberine dose-dependently inhibited the expression of [IL-8] and MCP-1 *induced* by or TNF-alpha . Positive_regulation IL8 IL1B 16413378 1513961 TNF-alpha and ( 0.01 to 100 ng/mL ) *induced* secretion of [IL-8] , IL-6 , and RANTES in a dose and time dependent manner . Positive_regulation IL8 IL1B 16529829 1555149 Globular adiponectin doubled *stimulated* [IL-8] and GM-CSF secretion . Positive_regulation IL8 IL1B 16564702 1549835 We investigated whether ATP and/or over-expression of the P2X7 receptor caused icIL-1ra1 inhibition of *mediated* [IL-8] reporter activation , by permitting its release . Positive_regulation IL8 IL1B 1660018 171372 Twenty-four-hour conditioned medium from lipopolysaccharide stimulated peripheral blood monocytes and nonparenchymal human liver cells enriched for Kupffer cells induced a time dependent increase in interleukin-8 messenger RNA levels in SK-hepatoma cells over a 24-hr period , similar to that seen for tumor necrosis factor-alpha or *induction* of [interleukin-8] in primary hepatocytes . Positive_regulation IL8 IL1B 16601138 1568720 The effects of adiponectin on *induced* secretion of IL-6 , [IL-8] , and monocyte chemoattractant protein 1 from cultured ESCs were determined using specific ELISAs . Positive_regulation IL8 IL1B 16601138 1568726 Adiponectin decreased *induced* secretion of IL-6 , [IL-8] , and monocyte chemoattractant protein 1 from ESCs . Positive_regulation IL8 IL1B 16610017 1545262 VacA alone *induced* expression of TNF-alpha , [IL-8] and IL-1beta , while NaCl alone induced expression of TNF-alpha and . Positive_regulation IL8 IL1B 16616208 1582988 The expression of IL-1beta , [IL-8] , and TNF-alpha markedly increased in the *presence* of after day 14 of culture . Positive_regulation IL8 IL1B 16619004 1569172 These findings suggest that TNF-alpha or primed HSCs *enhance* the production of [IL-8] in response to PGN and LTA through augmentation of the TLR2 system . Positive_regulation IL8 IL1B 16678783 1612122 The stimulatory effect of EGF on *induced* [IL-8] production was completely abolished by the broad range tyrosine kinase inhibitor Herbimycin A , and considerably reduced by the receptor tyrosine kinase specific inhibitor PD 153035 . Positive_regulation IL8 IL1B 16678783 1612124 Herbimycin A abolished [IL-8] production *induced* by , whereas PD 153035 had no effect on the cytokine induced IL-8 production . Positive_regulation IL8 IL1B 16678783 1612128 Furthermore , the p38 mitogen activated protein (MAP) kinase inhibitor SB 203580 reduced [IL-8] production *induced* by as well as by the combination of EGF and IL-1beta but had no effect on EGF induced IL-8 production . Positive_regulation IL8 IL1B 16678783 1612142 In conclusion , the study demonstrates that EGF synergistically stimulates [IL-8] production in the *presence* of and that tyrosine kinase ( s ) seem to be involved in the signalling pathway of IL-1beta and EGF . Positive_regulation IL8 IL1B 16723032 1589948 markedly up-regulated the hBD-2 promoter activity , and the subsequent DEP exposure *increased* dose-dependently the expression of hBD-2 and inflammatory cytokine [IL-8] at the transcriptional level . Positive_regulation IL8 IL1B 16739069 1576368 In this study , we investigated the effects of a defined green tea extract ( GTE ) or EGCG on basal or *induced* [IL-8] expression and secretion in the human gastrointestinal epithelial cell line Caco-2 . Positive_regulation IL8 IL1B 16739069 1576369 The mediated *increase* of [IL-8] secretion was significantly inhibited by GTE in a dose dependent manner . Positive_regulation IL8 IL1B 16739069 1576370 At the highest concentration , GTE inhibited *induced* [IL-8] secretion to a similar extent as found for brefeldin A , an inhibitor of vesicular transport . Positive_regulation IL8 IL1B 16740161 1585305 CpG DNA modulates *induced* [interleukin-8] expression in human bronchial epithelial ( 16HBE14o- ) cells . Positive_regulation IL8 IL1B 16740161 1585308 CpC ( a control ODN ) had no effect on *induced* [IL-8] levels . Positive_regulation IL8 IL1B 16740161 1585310 Silencing TLR9 using siRNA or pretreatment of cells with chloroquine had little effect on *induced* [IL-8] levels , but abolished CpG induced synergy . Positive_regulation IL8 IL1B 16816386 1600109 In this study , we found that Sb culture supernatant ( SbS ) inhibits [interleukin-8] production *induced* by C. difficile toxin A or in human colonocyte NCM460 cells in a dose dependent fashion . Positive_regulation IL8 IL1B 1681733 169052 In keeping with these biological activities and protein data , Northern blot analysis of total cellular RNA extracted from keratinocyte monolayers hybridized with a 32P labelled 1-kb cDNA to IL-8 mRNA , revealed induction of the [IL-8] gene in the *presence* of TNF-alpha and , but not IFN-gamma . Positive_regulation IL8 IL1B 16879867 1716309 [IL-8] production is correlated with active disease and is *dependent* upon and NF-kappaB signaling . Positive_regulation IL8 IL1B 17007741 1629009 Calcitonin gene related peptide inhibits *induced* [interleukin-8] secretion in human type II alveolar epithelial cells . Positive_regulation IL8 IL1B 17007741 1629011 In the present study , we investigated the effect of endogenous and exogenous CGRP on *induced* chemokine [interleukin-8 (IL-8)] secretion . Positive_regulation IL8 IL1B 17007741 1629013 CGRP-1 receptor antagonist hCGRP8-37 ( 0.1-1 nmol/L ) greatly amplified *induced* [IL-8] production . Positive_regulation IL8 IL1B 17007741 1629015 However , cell clones stably transfected with CGRP showed significantly inhibited mRNA and protein levels of [IL-8] *induced* by . Positive_regulation IL8 IL1B 17007741 1629017 These data imply that AEII cell derived CGRP suppress *induced* [IL-8] secretion in an autocrine/paracrine mode . Positive_regulation IL8 IL1B 17012372 1674162 TNF-alpha and *increased* IL-6 and [IL-8] 12- to 67-fold with higher levels in IB3 than C38 cells post-TNF-alpha ( P < 0.05 ) . Positive_regulation IL8 IL1B 17072061 1637717 NAC inhibited the *stimulated* ICAM-1 expression and [IL-8] release from both cell lines in a concentration dependent manner . Positive_regulation IL8 IL1B 17077666 1642380 *enhanced* the mRNA and/or protein levels of granulocyte-macrophage colony stimulating factor ( GM-CSF ) , [IL-8] , and monocyte chemotactic protein (MCP)-1 in HCE and IL-6 , IL-8 , MCP-3 , and regulated on T-cell activation expressed secreted ( RANTES ) in HCFs . Positive_regulation IL8 IL1B 17086498 1496985 *promotes* [IL-8] production , which can be modulated by a number of factors , including oxidative stress . Positive_regulation IL8 IL1B 17086498 1496986 Thus , we investigated the effect of oxysterols , including 25-hydroxycholesterol and 7beta-hydroxycholesterol , on *induced* [IL-8] production in Caco-2 cells ( a human colon carcinoma cell line ) . Positive_regulation IL8 IL1B 17100776 1644823 The [IL-8] and VEGF production induced by TWEAK was *augmented* synergistically by simultaneous stimulation with transforming growth factor (TGF)-beta1 or . Positive_regulation IL8 IL1B 17122965 1652784 HPE and *induced* a significant increase in [IL-8] production by MKN45 and HUVEC , respectively , along with NFkappaB activation , which was significantly inhibited by PPI . Positive_regulation IL8 IL1B 17126080 1677627 We investigated *induced* [CXCL8] and CCL5 secretion from primary normal human bronchial and small airway epithelial cells , and the alveolar cell line A549 . Positive_regulation IL8 IL1B 17126080 1677631 The IL-1 related cytokine IL-18 did not drive or modulate *induced* [CXCL8] or CCL5 secretion . Positive_regulation IL8 IL1B 17141217 1693753 We have further identified that interleukin-6 (IL-6) and from PMN-melanoma co-cultures synergistically *contribute* to IkappaB-alpha degradation and [IL-8] synthesis in PMNs . Positive_regulation IL8 IL1B 17227815 1703845 Lipopolysaccharide (LPS) and *stimulated* [IL-8] production by cervical stromal cells in a dose dependent manner . Positive_regulation IL8 IL1B 17227815 1703846 In contrast , *induced* [IL-8] production was significantly blocked by BAY11-7082 , but not by C3 transferase exoenzyme or Y-27632 . Positive_regulation IL8 IL1B 17227815 1703848 Transfection of the cervical stromal cells with RhoA small interfering RNA ( siRNA ) inhibited LPS stimulated IL-8 production , whereas *induced* [IL-8] production was not significantly inhibited by knockdown of RhoA with siRNA . Positive_regulation IL8 IL1B 1729366 180971 By using a specific RIA , we demonstrate that not only , but also TNF-alpha and LPS can *induce* abundant [IL-8] secretion from chondrocytes . Positive_regulation IL8 IL1B 17420005 1728714 Enhanced *induced* [IL-8] production in cystic fibrosis lung epithelial cells is dependent of both mitogen activated protein kinases and NF-kappaB signaling . Positive_regulation IL8 IL1B 17420005 1728715 To test whether other signaling pathways such as that of mitogen activated protein kinases ( MAPKs ) could be involved in *induced* [IL-8] production of CF cells , we investigated ERK1/2 , JNK , and p38MAP signaling compared to NF-kappaB . Positive_regulation IL8 IL1B 17420005 1728716 However , when used together , these inhibitors caused a blockade in *induced* [IL-8] production in CF cells . Positive_regulation IL8 IL1B 17482186 1848298 Addition of soluble IL-1RII ( 2.0 microg/mL ) significantly inhibited *induced* IL-6 and [IL-8] secretion by endometrial cells in vitro . Positive_regulation IL8 IL1B 17482186 1848299 Infection of endometrial cells with rAd-RII significantly decreased *induced* [IL-8] secretion , compared with the PBS and rAd-LacZ controls but had no significant effect on IL-6 secretion . Positive_regulation IL8 IL1B 17504902 1772684 Metformin suppresses *induced* [IL-8] production , aromatase activation , and proliferation of endometriotic stromal cells . Positive_regulation IL8 IL1B 17504902 1772686 Metformin dose-dependently suppressed *induced* [IL-8] production , cAMP induced mRNA expression and aromatase activity , and 5-bromo-2'-deoxyuridine incorporation in ESCs . Positive_regulation IL8 IL1B 17586709 1764344 Interestingly , neutralization of IL-1beta abolished IL-8 induction by mechanical stresses , indicating that is *essential* for [IL-8] induction , presumably though autocrine or paracrine mechanisms . Positive_regulation IL8 IL1B 17693924 1882324 Lastly , inhibition of exportin 1 attenuates monocyte chemoattractant protein , [IL-8] , and intercellular adhesion molecule expression in *response* to stimulation . Positive_regulation IL8 IL1B 17700564 1794529 IL-33 or also *induced* [IL-8] and IL-13 production in naïve HUCBMCs , and enhanced production of these cytokines in IgE/anti-IgE stimulated HUCBMCs , without enhancing secretion of either PGD ( 2 ) or histamine . Positive_regulation IL8 IL1B 17875325 1843374 This pattern was particularly marked in spleen , where also [IL-8] *followed* the expression pattern of . Positive_regulation IL8 IL1B 17876544 1796330 Both IL-17A and IL-17F augmented *induced* secretion of IL-6 , [IL-8] , LIF , MMP-1 , and MMP-3 . Positive_regulation IL8 IL1B 18026701 1827814 Glucosamine significantly suppressed the *induced* [IL-8] production as well as its mRNA expression ( p < 0.05 ) at 1 mM . Positive_regulation IL8 IL1B 18065201 1853646 stimulated activation of ERK1/2 and p38alpha MAPK *mediates* the transcriptional up-regulation of IL-6 , [IL-8] and GRO-alpha in HeLa cells . Positive_regulation IL8 IL1B 18184040 1838886 ZnCl ( 2 ) also amplified IFN-gamma production under the influence of IL-12 or IL-18 , whereas *induced* [IL-8] expression was not enhanced by the addition of ZnCl ( 2 ) , indicating that the effect observed on cytokine induced IFN-gamma is not of a general and unspecific nature . Positive_regulation IL8 IL1B 18344608 1886569 GL , as well as dexamethasone ( DEX ) inhibited both tumor necrosis factor (TNF)-alpha- and *induced* [IL-8] production , mRNA expression , and promoter activity in A549 cells . Positive_regulation IL8 IL1B 18377686 1944119 Ellagic acid , genistein and epigallocatechin gallate reduced ( 4- to 8-fold ) *induced* [IL-8] secretion , while resveratrol promoted ( 1.7-fold ) the secretion . Positive_regulation IL8 IL1B 18515093 1939686 LCA significantly decreased [IL-8] secretion *induced* by . Positive_regulation IL8 IL1B 18547319 1952260 In vitro , both leptin and resistin could induce [CXCL8] and tumour necrosis factor-alpha production by blood monocytes , and leptin could additionally *induce* and IL-1 receptor antagonist production . Positive_regulation IL8 IL1B 18565769 1984274 In the *presence* of , FGF-18 increased expression of ADAMTS-4 , aggrecan , BMP-2 , COL2A1 , CCL3 , CCL4 , CCL20 , CXCL1 , CXCL3 , CXCL6 , IL-1beta , IL-6 , and [IL-8] and decreased ADAMTS-5 , MMP-13 , CCL2 , and CCL8 . Positive_regulation IL8 IL1B 18586957 1953581 *induced* [IL-8] release was also repressed by PGE ( 2 ) and forskolin , whereas the beta(2)-adrenoceptor agonists were ineffective . Positive_regulation IL8 IL1B 18607537 1959552 *induced* both the [IL-8] and p53 mRNA expression and protein production of IL-8 , but not p53 . Positive_regulation IL8 IL1B 18653246 1954841 This [CXCL8] production was *dependent* on MDM and TNF-alpha production following viral and immune activation . Positive_regulation IL8 IL1B 18658272 1967183 Neither flagellin nor altered transepithelial fluxes of membrane-impermeant dextran ( 10 kDa ) or lucifer yellow ( mol wt = 457 ) , but both *activated* p38 , NF-kappaB , and [IL-8] secretion . Positive_regulation IL8 IL1B 18658272 1967187 It is concluded that : 1 ) flagellin and *activated* p38 , NF-kappaB , [IL-8] , and CFTR dependent anion secretion without altering tight junction permeability ; Positive_regulation IL8 IL1B 18787030 2012209 We previously reported that *induced* [IL-8] production in human endometrial stromal cells ( ESCs ) and that induction was regulated by substances implicated in implantation . Positive_regulation IL8 IL1B 18787030 2012210 Both basal and *induced* [IL-8] levels of cell supernatants were much higher in EECs than ESCs . Positive_regulation IL8 IL1B 18978040 2015149 CF and non-CF cell lines produced similar levels of IL-8 at baseline and equally increased [IL-8] secretion in *response* to , TNF-alpha , and the Toll-like receptor 2 agonist Pam3Cys . Positive_regulation IL8 IL1B 18996492 2016038 The knockdown of PBEF expression significantly inhibited *stimulated* [IL-8] secretion and mRNA level by 60 % and 70 % , respectively , and the knockdown of PBEF expression also significantly attenuated IL-1beta induced cell permeability by 29 % in epithelial cells and 24 % in endothelial cells . Positive_regulation IL8 IL1B 19086277 2000193 Effect of Lactobacillus GG and conditioned media on *induced* [IL-8] production in Caco-2 cells . Positive_regulation IL8 IL1B 19086277 2000194 We demonstrated that the pretreatment of Caco-2 cells with LGG significantly inhibited *induced* [IL-8] production . Positive_regulation IL8 IL1B 19086277 2000195 Furthermore , LGG attenuated the *induced* transcriptional activation of the [IL-8] gene and the NF-kappaB-responsive gene , and attenuated the IL-1beta induced IkappaBalpha degradation . Positive_regulation IL8 IL1B 19086277 2000199 LGG-CM attenuated *induced* [IL-8] production . Positive_regulation IL8 IL1B 19086277 2000200 LGG inhibited *induced* [IL-8] production in Caco-2 and this effect occurred at the transcriptional level , at least in part , by inhibition of the NF-kappaB signaling pathway . Positive_regulation IL8 IL1B 19086277 2000201 Both the structural material of LGG and the soluble factor secreted from LGG inhibited the *induced* [IL-8] production , and thus different substances may cause the effects . Positive_regulation IL8 IL1B 19117935 2060760 also *induced* MCP-1 , IL-6 , and [IL-8] more vigorously in TAO derived fibroblasts . Positive_regulation IL8 IL1B 19135383 2037666 We also found that *induced* release of [IL-8] from MH7A cells was completely blocked by pretreatment with the ( IL-8 ) inhibitor Bay11-7085 , indicating that activation of NF-kappaB signaling plays an important role in the secretion of IL-8 . Positive_regulation IL8 IL1B 19345267 2080902 Expression levels of both and IL-8 increased significantly after stimulation with live cells , but heat killed cells only *caused* increased [IL-8] expression . Positive_regulation IL8 IL1B 19345795 2057461 and PGF ( 2alpha ) ( 0.5-10 mumol/L ) also *induced* [IL-8] production and mRNA expression in pulp cells . Positive_regulation IL8 IL1B 19345795 2057463 Aspirin inhibited *induced* PGF ( 2alpha ) , but not [IL-8] production . Positive_regulation IL8 IL1B 19345795 2057472 These results indicate that *induced* [IL-8] production in pulp cells is not mainly via direct activation of cyclooxygenase and PGF ( 2alpha ) generation . Positive_regulation IL8 IL1B 19357230 2081166 Lipoxin A4 inhibits *induced* [IL-8] and ICAM-1 expression in 1321N1 human astrocytoma cells . Positive_regulation IL8 IL1B 19357230 2081168 As shown by quantitative RT-PCR , LXA ( 4 ) ( 10 nM ) significantly inhibited ( P < 0.05 ) the *induced* stimulation of [IL-8] and ICAM-1 expression in these cells . Positive_regulation IL8 IL1B 19357230 2081169 Furthermore , LXA ( 4 ) ( 10 nM ) decreased the expression of *induced* [IL-8] protein levels ( P < 0.05 ) . Positive_regulation IL8 IL1B 19410980 2075261 Bovine colostrum significantly inhibited *induced* [IL-8] and intracellar adhesion molecule-1 mRNA expression . Positive_regulation IL8 IL1B 19435930 2107013 Knockdown of TTP protein by siRNA elevated *induced* expression of granulocyte macrophage-colony stimulating factor ( GM-CSF ) and [IL-8] , demonstrating a role for TTP in feedback control . Positive_regulation IL8 IL1B 19503841 2091981 Secretion of [IL-8] from Hela cells infected with C. trachomatis was not *dependent* on and TNF- alpha induction . Positive_regulation IL8 IL1B 19592492 2130636 Stable lines of IL-18Ralpha depleted human A549 cells were generated using shRNA , resulting in an increase of *induced* IL-1alpha , IL-6 , and [IL-8] compared to scrambled small hairpin RNA . Positive_regulation IL8 IL1B 19594487 2105406 TNF-alpha seems to induce preferably the expression of RANTES , MCP-1 , interferon-inducible protein ( IP-10 ) and Interferon-Inducible T-cell Alpha Chemoattractant ( I-TAC ) , while *induces* mainly [IL-8] and epithelial neutrophil activating peptide 78 ( ENA-78 ) . Positive_regulation IL8 IL1B 19626664 2137607 however , it is not clear whether *regulates* [IL-8] expression in prostate cancer cells . Positive_regulation IL8 IL1B 19626664 2137609 Glucosamine is widely regarded as an anti-inflammatory agent and thus we hypothesized that if *activated* [IL-8] production in prostate cancer cells , then glucosamine ought to blunt such an effect . Positive_regulation IL8 IL1B 19626664 2137611 Glucosamine significantly inhibited *induced* [IL-8] secretion . Positive_regulation IL8 IL1B 19697035 2258173 In contrast , the expression of [IL-8] in both cell types was strongly *stimulated* by both and TNF-alpha . Positive_regulation IL8 IL1B 19728558 2134071 Stimulation of the cells with *induced* a series of proinflammatory genes ( IL1alpha , IL1beta , TNFalpha , [IL8] , monocyte chemoattractant peptide-1 and COX-2 ) , but if the cells were treated with hyperthermia prior to IL1beta expression , gene expressions were significantly decreased up to 8 h. Treatment with sulfur alone induced expression of observed genes up to 12 h . Positive_regulation IL8 IL1B 19777241 2271933 Effects of ( - ) -epigallocatechin-3-gallate on cyclooxygenase 2 , PGE ( 2 ) , and [IL-8] expression *induced* by in human synovial fibroblasts . Positive_regulation IL8 IL1B 19777241 2271935 The objective of this study was to examine the effects of ( - ) -epigallocatechin-3-gallate ( EGCG ) on cyclooxygenase 2 (COX-2) , prostaglandin E ( 2 ) ( PGE ( 2 ) ) , and [interleukin 8 (IL-8)] expression *induced* by in human synovial fibroblasts . Positive_regulation IL8 IL1B 19777241 2271936 PGE ( 2 ) and [IL-8] secretion was also *induced* by stimulation and significantly suppressed by EGCG . Positive_regulation IL8 IL1B 19786024 2153711 Subsequent pharmacological studies show that *induced* miR-146a , [IL-8] and RANTES production was regulated via NF-kappaB and JNK-1/2 whilst miR-146b expression was mediated via MEK-1/2 and JNK-1/2 . Positive_regulation IL8 IL1B 19880520 2171321 Hypoxia enhanced *induced* [interleukin-8] ( CXCL8 ) production in A549 cells and decreased the ability of dexamethasone to suppress the CXCL8 production . Positive_regulation IL8 IL1B 19887769 2197286 Both TNF-alpha and activated NF-kappaB and *stimulated* [IL-8] production . Positive_regulation IL8 IL1B 19887769 2197292 The present data do not support the hypothesis that ibuprofen down-regulates [IL-8] production in *response* to TNF-alpha and in CF respiratory epithelium . Positive_regulation IL8 IL1B 19921217 2203713 Influence of NFkappaB inhibitors on *induced* chemokine [CXCL8] and -10 expression levels in intestinal epithelial cell lines : glucocorticoid ineffectiveness and paradoxical effect of PDTC . Positive_regulation IL8 IL1B 19921217 2203716 *stimulated* [CXCL8] and CXCL10 mRNA and protein expression and was studied in Caco-2 and HT29 cells in the presence and absence of the NFkappaB inhibitors by quantitative real-time polymerase chain reaction and enzyme linked immunosorbent serologic assay , respectively . Positive_regulation IL8 IL1B 19926933 2167184 The [IL-8] secretion *induced* by hydrogen peroxide and by was not suppressed by IFF , suggesting that the inhibitory effect of isoflavone was specific for the TNF-alpha induced regulation of IL-8 . Positive_regulation IL8 IL1B 20029461 2192298 and IL-18 also significantly enhanced eosinophil survival , and *induced* the release of IL-6 and chemokines [CXCL8] and CCL2 via the activation of the NF-kappaB , p38 MAPK and ERK pathways . Positive_regulation IL8 IL1B 20032224 2205116 GTE ( 2.5-40 microg/ml ) inhibited *induced* MCP-1/CCL2 ( 10 ng/ml ) , RANTES/CCL5 , GROalpha/CXCL1 and [IL-8/CXCL8] production in human RA synovial fibroblasts ( P < 0.05 ) . Positive_regulation IL8 IL1B 20182449 2272433 IL-1alpha and *increased* mRNA production and protein secretion of the neutrophil chemotactic CXCL1 , CXCL2 , and [IL-8] in keratinocytes . Positive_regulation IL8 IL1B 20194723 2229327 Proinflammatory cytokine *stimulates* [IL-8] synthesis in mast cells via a leukotriene B4 receptor 2-linked pathway , contributing to angiogenesis . Positive_regulation IL8 IL1B 20194723 2229328 In this study , we showed that the proinflammatory cytokine *induces* the synthesis of [IL-8] , a potent angiogenic factor , in human mast cells via the leukotriene B(4) receptor (BLT)2 . Positive_regulation IL8 IL1B 20194723 2229335 For instance , knockdown of BLT2 and Nox1 with specific small interfering RNA , treatment with a specific BLT2 antagonist , LY255283 , or treatment with a potential Nox inhibitor , diphenylene iodonium , suppressed *induced* [IL-8] synthesis . Positive_regulation IL8 IL1B 20194723 2229336 Taken together , our results suggest that BLT2-Nox1-reactive oxygen species dependent pathway plays a role in promoting the secretion of [IL-8] from human mast cells in *response* to the proinflammatory cytokine , thus contributing to angiogenesis . Positive_regulation IL8 IL1B 20334899 2273157 In HCT 116 and HCT-8 colorectal adenocarcinoma cells , the production of [IL-8] immunoreactivity was *up-regulated* by , tumor necrosis factor (TNF)-alpha , the toll-like receptor (TLR) ligands double stranded RNA and peptidoglycan and phorbol ester . Positive_regulation IL8 IL1B 20423350 2247131 Pre-incubation with beta(2)-adrenoceptor agonists ( salbutamol , salmeterol , formoterol ) augmented the release and mRNA expression of IL-6 and [IL-8] *induced* by and IL-1beta plus histamine , whereas NF-kappaB dependent transcription was significantly repressed , and AP-1 dependent transcription was unaffected . Positive_regulation IL8 IL1B 20478455 2263045 and IL-6 simultaneously *induced* [IL-8] and monocyte chemoattractant protein-1 secretion in PDL cells , whereas SOCS-3 overexpression suppressed secretion of these chemokines through inhibition of phosphorylation in downstream signaling . Positive_regulation IL8 IL1B 20525168 2284200 We have therefore examined the role of miR-146a during the *stimulated* IL-6 and [IL-8] release and proliferation in primary human airway smooth muscle ( HASM ) cells . Positive_regulation IL8 IL1B 20525168 2284205 Functional studies indicated that induced miR-146a expression does not negatively *regulate* IL-6 and [IL-8] release or basal proliferation . Positive_regulation IL8 IL1B 20525168 2284211 However , inhibition of *induced* IL-6 and [IL-8] release was observed at the super-maximal intracellular miR-146a levels obtained by transfection with miR-146a mimics and indicates that studies using miRNA mimics can produce false positive results . Positive_regulation IL8 IL1B 20610647 2296856 KdPT potently suppressed *induced* IL-6 and [IL-8] expression . Positive_regulation IL8 IL1B 22517618 2618473 Here we demonstrate that significantly *increased* the expression and release of [interleukin-8] ( CXCL8 ) , monocyte chemotactic protein-1 ( CCL2 ) , and granulocyte macrophage colony stimulating factor ( CSF2 ) by primary human myometrial cells . Positive_regulation IL8 IL1B 22517618 2618476 Using selective EP receptor agonists and a selective EP(4) antagonist , we show that PGE ( 2 ) mediates the repression of *induced* release of [CXCL8] , CCL2 , and CSF2 via activation of the EP(2) and EP(4) receptors . Positive_regulation IL8 IL1B 23610962 2774603 IP6 had suppressive effect on basal and *stimulated* [IL-8] secretion by cells . Positive_regulation IL8 IL1B 23636809 2800393 We found that the loss of FOXO3 in myometrial cells was associated with a significant decrease in *induced* IL6 and [IL8] expression and production , cyclooxygenase ( [ COX]-2 , official symbol PTGS2 ) expression and subsequent prostaglandin ( PGE2 and PGF2alpha ) release , and matrix metalloproteinase 9 (MMP9) and mRNA expression and activity . Positive_regulation IL8 IL1B 7670776 322594 In addition , clinical improvement was associated with decreased synthesis of IL-1 beta , TNF-alpha and [IL-8] *induced* by bacterial lipopolysaccharide , IL-1 alpha and in PBMC in vitro . Positive_regulation IL8 IL1B 7751003 306743 TGF-beta was also found to enhance *induction* of [IL-8] mRNA levels at lower IL-1 beta concentrations ( 50 U/ml ) but had no effect at higher IL-1 beta concentrations ( 500 U/ml ) . Positive_regulation IL8 IL1B 7751003 306744 However , TGF-beta had no synergistic effect on *induction* of [IL-8] secretion . Positive_regulation IL8 IL1B 7875467 298281 TNF-alpha and dose-dependently *induced* [IL-8] production in HT-29 cells . Positive_regulation IL8 IL1B 7875467 298283 However , *induction* of [IL-8] by or TNF-alpha was reduced by the PTK inhibitors herbimycin ( by 79 % or 89 % , respectively ) and genistein ( by > 95 % ) . Positive_regulation IL8 IL1B 7875467 298288 The synthesis of [IL-8] is *stimulated* in HT-29 cells by or TNF-alpha . Positive_regulation IL8 IL1B 8052491 267767 TNF-alpha and significantly *augmented* the levels of mRNA expression for [IL-8] and its production . Positive_regulation IL8 IL1B 8069926 270002 Addition of anti-TNF and anti-IL-1 beta antibodies to IFN-gamma plus LPS treated PMN indicated that the LPS induced production of endogenous TNF and , which was further potentiated by IFN-gamma pretreatment , *mediated* in autocrine fashion the enhanced LPS induced [IL-8] accumulation observed at 18 hr . Positive_regulation IL8 IL1B 8112434 241834 Local production of [IL-8] in *response* to elastase and , together with the inactivation of the anti-inflammatory protein IL-6 , may result in a significant upregulation of airway inflammation in cystic fibrosis . Positive_regulation IL8 IL1B 8206512 261195 We demonstrated that [IL-8] was expressed by primary cultured HAEC and that this was *enhanced* by and tumour necrosis factor-alpha stimulation , but not by IL-6 or lipopolysaccharide . Positive_regulation IL8 IL1B 8216423 231663 TNF alpha and *induced* a time- and dose dependent release of immunoreactive [IL-8] . Positive_regulation IL8 IL1B 8274477 247108 Marked [IL-8] induction by Ox-LDL did not *require* generation in THP-1 cells . Positive_regulation IL8 IL1B 8360592 227786 While phorbol myristate acetate induced IL-1 beta and IL-8 mRNA expression was increased by RA ( IL-6 could not be induced by this pathway in monocytes ) , *induced* expression of IL-1 beta and [IL-8] was markedly reduced and IL-6 gene expression was almost completely suppressed . Positive_regulation IL8 IL1B 8432783 212835 Northern blot analysis confirmed that stimulation of chorion and decidual cells *resulted* in increased [IL-8] messenger RNA expression . Positive_regulation IL8 IL1B 8506955 221477 Stimulation of HPMC with or TNF-alpha *resulted* in a time- and dose dependent [IL-8] generation ; Positive_regulation IL8 IL1B 8544101 338864 IL-1 beta activation of GF cells showed that non only *induces* the expression of IL-6 , [IL-8] and TNF-alpha , but also acts in an autocrine manner of GF cells and induces IL-1 beta expression . Positive_regulation IL8 IL1B 8572249 340729 We hypothesized that RSV directly *induces* [interleukin (IL)-8] gene expression in airway epithelial cells , independent of and tumor necrosis factor-alpha (TNF-alpha) production . Positive_regulation IL8 IL1B 8598489 350733 does not cause neutrophil degranulation but does *lead* to IL-6 , [IL-8] , and nitrite/nitrate release when used in patients with cancer . Positive_regulation IL8 IL1B 8663179 368395 Both synthetic and natural glucocorticoids dexamethasone ( 10 ( -7 ) -10 ( -10 ) M ) and hydrocortisone ( 10 ( -6 ) -10 ( -8 ) M ) inhibited *stimulated* [IL-8] mRNA expression . Positive_regulation IL8 IL1B 8663179 368396 Furthermore , as determined by nuclear run-on analysis , IL-1beta increased the rate of transcription of IL-8 gene and dexamethasone did not affect the *induced* transcription of [IL-8] . Positive_regulation IL8 IL1B 8663179 368398 1- ( 5-Isoquinolinesulfonyl ) -2-methylpiperazine , HCl ( 50 microM ) and staurosporine ( 1 microM ) , potent inhibitors of protein kinase C , and genistein ( 100 microM ) , a specific protein tyrosine kinase inhibitor blocked *induced* [IL-8] gene expression . Positive_regulation IL8 IL1B 8663179 368399 Because curcumin ( 20 microM ) , an inhibitor of c-jun/AP-1 and protein kinases , also blocked *stimulated* [IL-8] gene expression implicating c-JUN/AP-1 and protein phosphorylation in the induction of IL-8 gene expression by IL-1beta , we conclude that the regulation of IL-8 mRNA by IL-1beta is mediated via protein kinase dependent signal transduction pathways . Positive_regulation IL8 IL1B 8941673 399299 By semiquantitative reverse transcriptase PCR , we demonstrated that IL-1alpha and *stimulated* the expression of KGF , HGF , IL-1alpha , IL-1beta , IL-1RI , and [IL-8] in fibroblasts regardless of their physiologic condition , whereas that of TGF-beta remained unaffected . Positive_regulation IL8 IL1B 8943702 400126 RPE monocyte chemotactic protein-1 mRNA peaked at 2 hr and decreased over 8 hr and 24 hr. Whereas , RPE interleukin-8 mRNA was perceptible at 2 hr , maximal at 8 hr , and reduced by 24 hr . Interleukin-7 potentiated *induced* monocyte chemotactic protein-1 and [interleukin-8] steady-state mRNA expression at all interleukin-7 concentrations . Positive_regulation IL8 IL1B 8955503 401397 Similarly , also *caused* chorion cells to produce more [IL-8] than MIP-1 alpha . Positive_regulation IL8 IL1B 8977194 408706 *stimulated* NF-kappaB nuclear translocation and NF-kappaB dependent IL-1beta and [IL-8] expression in both Caco-2 and HT-29 cells as assayed by electrophoretic mobility shift assay , immunofluorescence , kappaB-luciferase transfection , reverse transcriptase-PCR analysis and ELISA . Positive_regulation IL8 IL1B 8999951 409997 Although the nuclear factor-kappaB (NFkappaB) element regulates only inducible activity of the [IL-8] promoter in *response* to stimulation with , the AP-1 and CCAAT/Enhancer binding transcription factorein (C/EBP) elements influence both basal and inducible activities . Positive_regulation IL8 IL1B 9040477 415867 Although DEX ( 10 ( -8 ) to 10 ( -6 ) M ) inhibited *stimulated* MCP-1 and [IL-8] production , it did not inhibit TNF-alpha stimulated chemokine secretion . Positive_regulation IL8 IL1B 9077472 420393 Upon *stimulation* with and tumor necrosis factor-alpha (TNF-alpha) , both HDMECs and HMEC-1 expressed high levels of [IL-8] , GRO , and monocyte chemoattractant protein-1 ( MCP-1 ) . Positive_regulation IL8 IL1B 9166282 432334 Maximum levels of TNF alpha and [IL-8] were *detected* at 2 hours after LPS-injection , whereas and IL-1 receptor antagonist (IL-1Ra) were detected at 6 and 9 hours , respectively . Positive_regulation IL8 IL1B 9166282 432342 These results provide new evidence that [IL-8] as well as TNF alpha are the most proximal cytokines and *induce* subsequent production of and IL-1Ra . Positive_regulation IL8 IL1B 9211547 441376 Analysis of covariance including all subjects showed that the presence of acute inflammation was associated with increased mRNA levels in mucosa ( P = .035 ) and *increased* [IL-8] in full-thickness sections ( P = .005 ) and mucosa ( P = .01 ) . Positive_regulation IL8 IL1B 9237814 445740 *Stimulation* of [IL-8] production in human gastric epithelial cells by Helicobacter pylori , and TNF-alpha requires tyrosine kinase activity , but not protein kinase C . Positive_regulation IL8 IL1B 9237814 445768 Helicobacter pylori , tumour necrosis factor alpha and produced a dose dependent *increase* in [IL-8] production . Positive_regulation IL8 IL1B 9349985 460807 CsA ( 1 , 5 , and 10ng/ml ) significantly reduced *induced* [IL-8] production ( by 32 % , 41 % , and 48 % , respectively ) , and reduced TNF alpha induced IL-8 production ( by 21 % , 42 % , and 50 % , respectively ) . Positive_regulation IL8 IL1B 9365094 463085 However , the secretion of IL-6 , [IL-8] , and GM-CSF stimulated by the complexes was not completely *dependent* upon the secretion of . Positive_regulation IL8 IL1B 9405662 470078 These are : ( i ) inhibition of *induced* [IL-8] production by peripheral blood mononuclear cell , ( ii ) inhibition of spontaneous IL-8 production by cultured human monocytes , ( iii ) induction of IL-1 receptor antagonistic protein production by human monocytes , ( iv ) induction of chemotactic migration of CD8+ human T lymphocytes in vitro , ( v ) desensitization of human CD8+ T cells resulting in an unresponsiveness toward rhIL-10 induced chemotaxis , ( vi ) suppression of the chemotactic response of CD4+ T human lymphocytes toward IL-8 , ( vii ) induction of IL-4 production by cultured normal human CD4+ T cells , ( viii ) down-regulation of tumor necrosis factor-alpha production by CD8+ T cells , and ( ix ) inhibition of class II major histocompatibility complex antigen expression on IFN-gamma stimulated human monocytes . Positive_regulation IL8 IL1B 9427069 472693 Administration of TNF alpha or *induced* [IL-8] production ; Positive_regulation IL8 IL1B 9441701 475946 Substantial dose- and time dependent RPE secretion of [IL-8] was *observed* following stimulation with or TNF-alpha , but cell associated IL-8 was detectable only after high dose ( 20 ng ml-1 ) IL-1 beta stimulation and comprised less than 1 % of the total IL-8 induced . Positive_regulation IL8 IL1B 9520946 493671 In the present study , we further examined the effects of GHSA on TNF-alpha- and *induced* HRPE [IL-8] and monocyte chemoattractant protein (MCP)-1 gene expression and protein secretion in HRPE . Positive_regulation IL8 IL1B 9520946 493674 Moreover , potentiation of HRPE IL-8 generation by GHSA appeared to be selective for TNF-alpha because , under similar conditions , GHSA was unable to enhance the *stimulated* [IL-8] gene expression and protein secretion . Positive_regulation IL8 IL1B 9551998 499169 *Induction* of inducible nitric-oxide synthase (iNOS) , IL-1beta , and [IL-8] genes by , TNF-alpha , or PMA was blocked in Ad5 IkappaB infected cells but not in Ad5 LacZ controls as assayed by RT-PCR and ELISA . Positive_regulation IL8 IL1B 9551998 499172 In addition , *induced* [IL-8] secretion was totally inhibited by Ad5 IkappaB in primary colonic IEC . Positive_regulation IL8 IL1B 9561561 500524 IL4 enhanced *induced* HIV1 and [IL8] expression in promonocytic U1 cells , whereas it suppressed their expression induced by cytokines IL6 , GM-CSF and to a small extent , TNF alpha . Positive_regulation IL8 IL1B 9586676 504544 As anticipated , *induced* a marked release of collagenase , stromelysin , IL-6 , [IL-8] and PGE2 . Positive_regulation IL8 IL1B 9611001 508912 *induced* a significant increase in [interleukin-8] secretion by fibroblasts in vitro , from 0.8 ng/10 ( 6 ) cells to 35.6 ng/10 ( 6 ) cells . Positive_regulation IL8 IL1B 9636165 513342 In the presence of a specific p38 MAPK inhibitor (p38 inh) , IL-1beta induced HIV production was suppressed by more than 90 % and *induced* [IL-8] production was suppressed completely , both with IC50 of 0.01 microM . Positive_regulation IL8 IL1B 9657919 516890 and TNF-alpha synergistically *induced* IL-6 and GM-CSF and additively induced [IL-8] and MCP-1 production , while IL-2 , IL-10 , IFN-alpha , and IFN-gamma had little or no additional effects . Positive_regulation IL8 IL1B 9659156 517169 Stimulation of HIMEC and HUVEC with recombinant human ( rh ) or rhTNF-alpha *induced* cell associated bioactive IL-1 alpha but not IL-1 beta , as well as enhanced secretion of both IL-6 and [IL-8] . Positive_regulation IL8 IL1B 9665590 518470 Immunohistochemical staining demonstrated that IL-10 markedly suppressed lipopolysaccharide (LPS)- and *stimulated* [IL-8] expression . Positive_regulation IL8 IL1B 9665590 518471 NF-kappaB involvement was suggested by the finding that pyrrolidinedithiocarbamate , a known inhibitor of NF-kappaB activation , blocked LPS- and *induced* [IL-8] production . Positive_regulation IL8 IL1B 9809626 545440 A significant suppression ( 75 % , p < 0.001 ) of *induced* [IL-8] production 3 and 6 h after IFN-alpha2b compared with control subjects was observed . Positive_regulation IL8 IL1B 9831176 551449 and interferon-gamma differentially *regulate* release of monocyte chemotactic protein-1 and [interleukin-8] by human bronchial epithelial cells . Positive_regulation IL8 IL1B 9831176 551462 *increased* both MCP-1 and [IL-8] release , and increased the expression of ICAM-1 and CD40 , but not HLA class II molecules . Positive_regulation IL8 IL1B 9831176 551466 Our results indicate that IFN-gamma and differentially *regulate* the MCP-1 and [IL-8] release by human bronchial epithelial cells . Positive_regulation IL8 IL1B 9893037 558646 and TNF-alpha *induced* the synthesis of [IL-8] at 24 hr , but partially inhibited the synthesis at 48 hr . Positive_regulation IL8 IL1R2 8387521 218046 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL8 ITGB2 10590045 572277 As evident from antibody blocking experiments , PF-4 induced adhesion involved PMN expressed L-selectin as well as leukocyte function associated molecule-1 ( LFA-1 ) , whereas [IL-8] *involved* . Positive_regulation IL8 ITGB2 1356557 198028 The *role* of in [IL-8] induced dermal and synovial inflammation . Positive_regulation IL8 ITGB2 14613935 1187973 Co-stimulating and CD11b with activating antibodies *resulted* in NF-kappaB activation by GM-CSF and [IL-8] in suspended cells . Positive_regulation IL8 ITGB2 17332440 1747958 Peptidoglycan ( PGN ) ( TLR2 ligand ) , flagellin ( TLR5 ligand ) , and Imiquimod R837 ( TLR7 ligand ) could significantly upregulate cell surface expression of intercellular adhesion molecule (ICAM)-1 and , and *induce* the release of IL-1beta , IL-6 , [IL-8] , growth related oncogene ( GRO ) -alpha , and superoxides of eosinophils . Positive_regulation IL8 ITGB2 7514637 254114 Zymosan induced [IL-8] release from human neutrophils *involves* activation via the receptor and endogenous platelet activating factor as an autocrine modulator . Positive_regulation IL8 LBP 16249503 1471754 In a dose-dependant manner , tear CD14 and *mediated* the secretion of interleukin (IL)-6 and [IL-8] by corneal epithelia cells when challenged with LPS . Positive_regulation IL8 MAP2K6 11234901 789759 Basal and tumor necrosis factor-alpha-inducible phosphorylation of ERK1/2 and secretion of [IL-8] and VEGF could be specifically *inhibited* by a inhibitor , U0126 . Positive_regulation IL8 MAP2K6 11381075 820617 Combined inhibition of MEK by U0126 , p38 by SB202190 , and Janus kinase (jak) by AG490 revealed that GHSA stimulation of [IL-8] production was predominately *mediated* by and to a lesser extent by p38 pathways , whereas activation of MEK , p38 , and jak was required for maximal MCP-1 induction . Positive_regulation IL8 MAP2K6 11413312 828910 The inhibitors PD98059 and U0126 *blocked* Erk activation and release of [IL-8] following infection with Ad7 . Positive_regulation IL8 MAP2K6 11413312 828920 The expression of a mutated form of Ras in A549 epithelial cells blocked the induction of [IL-8] promoter activity , and inhibitor *blocked* induction of IL-8 mRNA . Positive_regulation IL8 MAP2K6 15894298 1440151 In addition , we found that a second and more potent inhibitor ( U0126 ) significantly *blocked* [CXCL8] release in epithelial cells by M. bovis BCG . Positive_regulation IL8 MAP2K6 15894298 1440158 Collectively , the findings reported in the present study suggest that signaling is *essential* for the induction of [CXCL8] in epithelial cells in response to M. bovis BCG . Positive_regulation IL8 MAP2K6 16197369 1500866 The LPA induced secretion of [IL-8] was *blocked* by the p38 MAPK inhibitor SB203580 , by p38 MAPK siRNA ( small interfering RNA ) , and by the JNK inhibitor JNK(i) II , but not by the ( MAPK/ERK kinase ) inhibitor , PD98059 . Positive_regulation IL8 MAP2K6 18390828 1913317 Selective inhibitors ( U0126 and PD-98059 ) *blocked* both [IL-8/CXCL8] release and ERK1/2 phosphorylation . Positive_regulation IL8 MAP2K6 18830271 2028482 Next , we confirmed that selective inhibitors significantly *inhibited* IL-17F induced [IL-8] production . Positive_regulation IL8 MAP2K6 19103208 2036318 Inhibitors of STAT1 , ( MEK ) ( PD98059 ) , and phosphatidyl inositol 3 kinase (PI3K) ( LY294002 ) , blocked gp120 induced STAT1 activation and significantly *diminished* [IL-8-] , IL-6- , and gp120 induced monocyte adhesion and migration across in vitro BBB models . Positive_regulation IL8 MAP2K6 20460732 2262916 However , PD98059 ( a MEK1/2 inhibitor ) dramatically down-regulated this cytokine , suggesting *dependent* [IL-8] production . Positive_regulation IL8 MAP2K6 22411631 2630615 The specific inhibitor , U0126 , *blocks* N. fowleri mediated AP-1 activation and subsequent [IL-8] induction . Positive_regulation IL8 MATN2 19840795 2165257 stimulation *leads* to the induction of MMP1 , MMP3 , MMP13 , COX-2 , iNOS , IL-1beta , TNFalpha , IL-6 and [IL-8] . Positive_regulation IL8 MMP28 18390828 1913294 In A549 cells , synthetic inhibitors *prevented* rhMMP-12 induced [IL-8/CXCL8] release . Positive_regulation IL8 MMP7 18390828 1913309 In A549 cells , synthetic inhibitors *prevented* rhMMP-12 induced [IL-8/CXCL8] release . Positive_regulation IL8 PGC 22117073 2535023 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL8 RCAN1 19348862 2094414 A modulatory role for RCAN1-4 is demonstrated by RCAN1-4 overexpression which results in the inhibition of PROK1 induced IL-8 expression whereas reduction in endogenous expression *results* in an increase in PROK1 induced [IL-8] production . Positive_regulation IL8 RCAN1 19716405 2158163 also *stimulated* IL-1R mediated signaling pathways , TAK1 activation , NF-kappaB transactivation , and [IL-8] production , all downstream consequences of IL-1R activation . Positive_regulation IL8 RNASE1 8594414 335322 The effect of L-RNA was dependent of the integrity of the polynucleotide chain and was not due to LPS contamination since its ability to induce MNCF and [IL-8] release was strongly *reduced* by but was not affected by DNase or polymyxin B . Positive_regulation IL8 RNASE7 8594414 335330 The effect of L-RNA was dependent of the integrity of the polynucleotide chain and was not due to LPS contamination since its ability to induce MNCF and [IL-8] release was strongly *reduced* by but was not affected by DNase or polymyxin B . Positive_regulation IL8 SLC38A3 15623601 1349049 *mediated* release of [interleukin (IL)-8] from HUVECs and G17 induced modifications in nuclear factor-kappaB DNA binding activity were characterized by means of specific enzyme linked immunosorbent assays . Positive_regulation IL8 SPHK1 17306937 1705220 Dimethylsphingosine , an inhibitor of , partially *inhibited* TNF-alpha induction of [IL-8] mRNA levels indicating the importance of intracellular increases in S1-P in the IL-8 induction . Positive_regulation IL8 STAT4 7638186 317688 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL8 TF 11967015 933026 *up-regulated* monocyte chemoattractant peptide-1 , [interleukin-8] , and macrophage migration inhibitory factor expression in a time- and dose dependent fashion , but had no effect on RANTES expression by PTEC . Positive_regulation IL8 TLR7 12045249 950128 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL8 TLR7 15804290 1390889 The ligands peptidoglycan , Pam3Cys and flagellin which bind to TLR2 , TLR1/TLR2 heterodimer , and TLR5 , respectively , also *induced* IL-8 secretion , whereas no [IL-8] was induced by LPS , R-848 , loxoribine and cytosine guanine dinucleotide containing oligodeoxynucleotide . Positive_regulation IL8 TLR7 15908363 1409462 Collectively , these data suggest that the scarcity of neutrophils in intestinal infiltrates of typhoid fever patients is due to a capsule mediated reduction of *dependent* [IL-8] production in the intestinal mucosa . Positive_regulation IL8 TLR7 17452051 1743116 Anti-RP3 Abs markedly promoted the release of [IL-8] *induced* by chemically synthesized and NOD ligands mimicking bacterial components : TLR2-agonistic lipopeptide ( FSL-1 ) , TLR3-agonistic poly I:C , TLR4-agonistic lipid A ( LA-15-PP ) , TLR7/8-agonistic single stranded RNA ( ssPolyU ) , TLR9-agonistic bacterial CpG DNA , NOD1-agonistic FK156/565 and NOD2-agonistic muramyldipeptide ( MDP ) in THP-1 cells and human peripheral blood mononuclear cells , although sole incubation with anti-PR3 Abs induced only a low level of IL-8 . Positive_regulation IL8 TLR7 17578764 1763646 The aim of this study was to clarify the *role* of different ligands in [IL8] production in NCI-H295R cells . Positive_regulation IL8 TLR7 18312842 1879508 Toxoplasma profilin is essential for host cell invasion and dependent *induction* of an [interleukin-12] response . Positive_regulation IL8 TLR7 18375743 1912959 We conclude that multiple ligands *induce* airway epithelial cell production of [IL-8] and VEGF via a Duox1 -- > ROS -- > TACE -- > TGF-alpha -- > EGFR phosphorylation pathway . Positive_regulation IL8 TLR7 18544685 1952230 We and others have reported that Toll-like receptor (TLR) proteins are present on human neutrophils and that granulocyte-macrophage colony stimulating factor ( GM-CSF ) treatment enhances [IL-8] ( CXCL8 ) secretion in *response* to stimulation with ligands . Positive_regulation IL8 TLR7 19129482 2047928 Priming with the allergic mediators histamine , IL-4 , and most prominently IL-5 , augmented the *induced* [IL-8] and EDN secretion , revealing an ability to sensitize eosinophils for TLR7 and TLR9 activation . Positive_regulation IL8 TLR7 19527497 2103254 Activation of TLR8 , but not , *augmented* [IL-8] release . Positive_regulation IL8 TLR7 19786303 2163904 Collectively , these results suggest that flagellin induced [IL-8] expression *requires* formation of lipid rafts , intracellular activation , and subsequent activation of PKC and MAP kinases leading to the activation of the transcription factors NF-kappaB and NF-IL6 in human alveolar type II epithelial cells . Positive_regulation IL8 TLR7 19897783 2166046 In human gingival fibroblasts , cyclosporin alone did not induce evident inflammatory responses , but augmented the expression of CD54 and the production of interleukin (IL)-6 and [IL-8] *induced* by ligands , whereas phenytoin attenuated those responses . Positive_regulation IL8 TLR7 20334899 2273152 In HCT 116 and HCT-8 colorectal adenocarcinoma cells , the production of [IL-8] immunoreactivity was *up-regulated* by IL-1beta , tumor necrosis factor (TNF)-alpha , the ligands double stranded RNA and peptidoglycan and phorbol ester . Positive_regulation IL8 TLR7 20354173 2266511 The increase in IL-8 release occurred despite reduced IL-8 mRNA levels in the donor granulocytes after in vivo G-CSF/dexa treatment , indicating that the enhanced *induced* [IL-8] production was largely determined by posttranscriptional regulation . Positive_regulation IL8 TLR7 20632067 2368021 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in mediated *activation* of caspase 1 and [interleukin-1ß] . Positive_regulation IL8 TLR7 21453321 2412647 In addition , enhanced TLR2 induced TNFa release , TLR3 induced IL-8 release , TLR4 induced IL1ß and TNFa release , TLR5 induced IL1ß and TNFa release and *induced* [IL-8] release were also observed in IBS patients . Positive_regulation IL8 TLR7 22188581 2549502 *induced* [IL-8] production before myocardial stress induction was not associated with the results of SPECT-MPI . Positive_regulation IL8 TLR7 22521509 2613639 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL8 TLR7 23246311 2732203 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL8 TNF 10063910 593324 N-Acetylcysteine (NAC) or dimethylsulfoxide inhibited [IL-8] expression *induced* by or interleukin-1beta (IL-1beta) . Positive_regulation IL8 TNF 10201981 605767 We characterized the effect of a dominant negative TRAF-2 delivered by an adenoviral vector ( Ad5dnTRAF-2 ) on the cytokine signaling cascade in several IEC and also investigated whether inhibiting the TRAF-2 transmitting signal blocked *induced* NF-kappa B and [IL-8] gene expression . Positive_regulation IL8 TNF 10201981 605773 *Induction* of [IL-8] gene expression by was partially inhibited in Ad5dnTRAF-2 transfected HT-29 , but not in control Ad5LacZ infected , cells . Positive_regulation IL8 TNF 10372996 622122 IL-4 potentiates IL-1beta- and *stimulated* [IL-8] and MCP-1 protein production in human retinal pigment epithelial cells . Positive_regulation IL8 TNF 10372996 622125 It has been shown in this and other laboratories that interleukin-1 beta (IL-1beta) and are potent *inducers* of HRPE [IL-8] and MCP-1 secretion . Positive_regulation IL8 TNF 10372996 622136 IL-1beta and *induced* dose dependent increases in HRPE [IL-8] and MCP-1 secretion with maximal stimulation observed at 2-5 ng/ml . IL-4 alone ( 100 ng/ml ) resulted in a slight increase of MCP-1 and IL-8 secretion . Positive_regulation IL8 TNF 10372996 622141 HRPE [IL-8] and MCP-1 gene expression and protein production are *stimulated* by IL-1beta or through pathways differentially modulated by IL-4 and GM-CSF . Positive_regulation IL8 TNF 10376933 623523 These data suggest that extracellular tat , especially in the *presence* of , may be responsible for the local production of [IL-8] . Positive_regulation IL8 TNF 10384135 624766 Involvement of thioredoxin in rheumatoid arthritis : its costimulatory roles in the *induced* production of IL-6 and [IL-8] from cultured synovial fibroblasts . Positive_regulation IL8 TNF 10384135 624768 We thus examined the effect of TRX on the *induced* IL-6 and [IL-8] production using rheumatoid synovial fibroblast cultures . Positive_regulation IL8 TNF 10384135 624772 The extents of IL-6 and [IL-8] production in *response* to were greatly augmented by TRX as compared with TNF-alpha alone . Positive_regulation IL8 TNF 10417153 631476 [IL-8] gene transcription in L5F11 cells could also be *induced* by the cytokine without exposure to H. pylori . Positive_regulation IL8 TNF 10417153 631477 This *induced* [IL-8] transcription was inhibited by the protein kinase A inhibitor H7 , which had no significant effect on H. pylori induced IL-8 transcription . Positive_regulation IL8 TNF 10418175 631656 Subsequently , and IL-1 , together with endotoxin , *stimulate* circulating and local [IL-8] in ALD . Positive_regulation IL8 TNF 10425270 632807 In contrast , the pro-inflammatory cytokine , whose activity is dependent on the generation of intracellular ROS , *induces* [IL-8] and ICAM-1 in both cell types . Positive_regulation IL8 TNF 10445612 636207 and IL-1alpha- *induced* phosphorylation and activation of p38 MAP kinase and [IL-8] expression in human pulmonary endothelial cells . Positive_regulation IL8 TNF 10445612 636213 Inhibition of and IL-1alpha induced p38 MAP kinase activity by SB 203580 *inhibited* TNF-alpha- and IL-1alpha induced [IL-8] protein production as well as IL-8 messenger ribonucleic acid ( mRNA ) expression , indicating that SB 203580 was effective at the transcriptional level . Positive_regulation IL8 TNF 10460229 639652 Human placental cells show enhanced production of [interleukin (IL)-8] in *response* to lipopolysaccharide (LPS) , IL-1 and , but not to IL-6 . Positive_regulation IL8 TNF 10460229 639656 The placental cells also release [IL-8] in a dose dependent manner , in *response* to r- ( recombinant ) IL-1alpha and , but not rIL-6 . Positive_regulation IL8 TNF 10462040 639924 [IL-8] *induction* by was redox sensitive , as indicated by electron spin resonance analysis and inhibition with membrane permeable hydroxyl scavengers . Positive_regulation IL8 TNF 10462040 639925 Furthermore using cell transfection and mobility shift assays , it was found that transcriptional activation of the [IL-8] gene *required* induced activation and binding of nuclear factor-kappaB (NF-kappaB)- and NF-IL-6 , nuclear transcription factors to regulatory elements in the IL-8 promoter . Positive_regulation IL8 TNF 10464065 640269 The short-chain fatty acids , acetate , propionate , butyrate and valerate , the activator of protein kinase C ( phorbol-12-myristate-13-acetate ) and all *stimulated* the secretion of [IL-8] . Positive_regulation IL8 TNF 10475301 642717 We found that ketamine suppressed lipopolysaccharide induced tumor necrosis factor alpha , interleukin (IL)-6 , and IL-8 production and recombinant human *induced* IL-6 and [IL-8] production in human whole blood . Positive_regulation IL8 TNF 10477716 643258 is a rapid *activator* of [IL-8] gene expression by U937 , producing a 50-fold induction of mRNA within 1 hour of treatment . Positive_regulation IL8 TNF 10483900 643912 In the in vitro experiment , sodium butyrate dose-dependently inhibited *induced* [IL-8] secretion in HT-29 cells . Positive_regulation IL8 TNF 10540155 563249 In the intestinal epithelial cell lines HT-29 , T84 and Caco-2 , sodium butyrate enhanced TNF-alpha induced C3 secretion , but suppressed *induced* factor B and [IL-8] secretion . Positive_regulation IL8 TNF 10565568 567378 IL-13 did not affect the release of [IL-8] *induced* by ( 111 +/- 9 pM ) . Positive_regulation IL8 TNF 10592469 572818 In that regard , the transcription factor , nuclear factor , Kappa B ( NF-kappaB ) , is an important activator of *induced* [IL-8] gene expression in monocytes , lymphocytes and neutrophils . Positive_regulation IL8 TNF 10592469 572822 Stimulation of eosinophils with GM-CSF + *induced* significant increases in the synthesis and secretion of [IL-8] which were associated with translocation of NF-kappaB p50 into the nucleus . Positive_regulation IL8 TNF 10615065 656327 Northern blot analyses showed that CAM inhibited *induced* [IL-8] gene expression in a dose- and incubation time dependent manner . Positive_regulation IL8 TNF 10617974 657250 Consumption of the n-3 fatty acid docosahexaenoic acid ( DHA ; 22 : 6n-3 ) reduced endothelial expression of vascular cell adhesion molecule 1 ( VCAM-1 ) , E-selectin , intercellular adhesion molecule 1 ( ICAM-1 ) , interleukin 6 (IL-6) , and [IL-8] in *response* to IL-1 , IL-4 , , or bacterial endotoxin , with a half-maximal inhibitory concentration ( IC ( 50 ) ) of 1-25 micromol , ie , in the range of nutritionally achievable plasma concentrations . Positive_regulation IL8 TNF 10619828 657343 In addition , plus IL-1beta plus interferon-gamma (IFN-gamma) *increased* [IL-8] in culture supernatant of epithelial cells ; Positive_regulation IL8 TNF 10619864 657388 [IL-8] secretion *induced* by both the prototypical proinflammatory cytokine and S. typhimurium was NF-kappaB dependent . Positive_regulation IL8 TNF 10619864 657391 However , NF-kappaB activation and [IL-8] secretion *induced* by S. typhimurium , but not by , was preceded by and required an increase in intracellular [ Ca ( 2+ ) ] . Positive_regulation IL8 TNF 10629462 659540 Both IL-4 and IL-13 synergistically enhanced TNF-alpha induced eotaxin production , whereas [IL-8] production *induced* by was significantly down-regulated by the T ( H ) 2-derived cytokines . Positive_regulation IL8 TNF 10666108 665370 Hyperoxia synergistically increases *induced* [interleukin-8] gene expression in A549 cells . Positive_regulation IL8 TNF 10666108 665371 Hyperoxia alone had a minimal effect on [IL-8] gene expression , and alone *increased* IL-8 gene expression in a time dependent manner . Positive_regulation IL8 TNF 10666108 665372 Experiments involving IL-8 promoter-reporter assays , electromobility shift assays , and Western blot analyses demonstrated that hyperoxia augmented *mediated* activation of the [IL-8] promoter by a nuclear factor (NF)-kappaB dependent mechanism and increased the duration of NF-kappaB nuclear translocation after concomitant treatment with TNF-alpha . Positive_regulation IL8 TNF 10666108 665373 We conclude that hyperoxia alone has a minimal effect on IL-8 gene expression but synergistically increases [IL-8] gene expression in the *presence* of by a mechanism involving cooperative interaction between the transcription factors NF-kappaB and NF-IL-6 . Positive_regulation IL8 TNF 10670836 666664 Grepafloxacin inhibits *induced* [interleukin-8] expression in human airway epithelial cells . Positive_regulation IL8 TNF 10671210 666691 Neutralization of TNF by TNF binding protein and blockade of IL-1 receptors by IL-1 receptor antagonist revealed that TNF , IL-1 and IL-6 production was independent from each other , whereas [IL-8] synthesis was strongly *dependent* on endogenous and IL-1 . Positive_regulation IL8 TNF 10683319 707331 Besides TPA , also distinctively *enhanced* [IL-8] and MCP-1 production . Positive_regulation IL8 TNF 10690897 670462 *induced* the gene and protein expression of [IL-8] in endometriotic stromal cells in a dose dependent fashion . Positive_regulation IL8 TNF 10704251 672814 Pretreatment with either isohelenin or parthenolide inhibited *mediated* [IL-8] gene expression in a concentration dependent manner . Positive_regulation IL8 TNF 10704251 672815 Pretreatment with either compound inhibited *mediated* activation of the [IL-8] promoter and TNF-alpha mediated nuclear translocation of NF-kappaB . Positive_regulation IL8 TNF 10707928 673449 IL-1beta and both *induced* a marked increase in C3 and [IL-8] secretion . Positive_regulation IL8 TNF 10766192 684371 We further report that *induced* [IL-8] production was indeed strongly enhanced upon IGF-I addition , and this effect was totally abrogated by both MAPK and NF-kappaB inhibitors . Positive_regulation IL8 TNF 10768935 685068 [IL-8] , IL-1alpha , IL-1beta , MCP-1 , GM-CSF , and mRNA expression *increased* within 1 h postinfection , reached a maximum after 3 to 4 h , and then declined to preinfection levels within 3 h . IL-8 , MCP-1 , and GM-CSF were secreted by HeLa cells , whereas IL-1alpha and IL-1beta were not secreted and thus were found exclusively intracellularly . Positive_regulation IL8 TNF 10775461 686622 Here , we investigated whether arsenic , which has been shown to inhibit the ubiquitin-proteasome pathway , could inhibit *mediated* increases in [IL-8] expression . Positive_regulation IL8 TNF 10795756 689766 CAPAN-1 cells had concentration dependent production of IL-6 and [IL-8] in *response* to both endotoxin and . Positive_regulation IL8 TNF 10795756 689770 CAPAN-2 cells had concentration dependent production of IL-6 and [IL-8] in *response* to . Positive_regulation IL8 TNF 10805216 691954 IFNs may have a general modulating effect , since IFN-alpha also inhibited the *induced* [IL-8] secretion . Positive_regulation IL8 TNF 10809292 692520 Perfluorocarbon blocks *induced* [interleukin-8] release from alveolar epithelial cells in vitro . Positive_regulation IL8 TNF 10809292 692522 To determine whether *induced* [interleukin (IL)-8] production by pulmonary alveolar epithelial cells is blocked by perfluorocarbon (PFC) . Positive_regulation IL8 TNF 10809292 692523 To determine *induced* [IL-8] production , IL-8 was measured by using a human IL-8 kit in both control and experimental groups . Positive_regulation IL8 TNF 10809292 692525 stimulation *induced* a large increase in [IL-8] . Positive_regulation IL8 TNF 10809292 692528 When added to the lower chamber , also *induced* [IL-8] production unaffected by the addition of PFC to the upper chamber . Positive_regulation IL8 TNF 10809292 692529 The decrease in *induced* [IL-8] production depended on the time of PFC administration after the initiation of TNF-alpha stimulation . Positive_regulation IL8 TNF 10820277 694429 Promoter deletion and mutagenesis experiments indicate that although the region from -99 to -54 nt is sufficient for *induced* [IL-8] transcription , this region alone is not sufficient for RSV induced IL-8 transcription . Positive_regulation IL8 TNF 10822085 694698 *induced* expression of both [IL-8] and GM-CSF , without detectable production of RANTES . Positive_regulation IL8 TNF 10843739 700314 Our analysis revealed that purified human MO did not respond to exogenous TNF-alpha with the induction of IL-8 mRNA or protein , nor *require* endogenous for [IL-8] expression . Positive_regulation IL8 TNF 10843739 700317 In contrast with MO , purified LY and non fractionated PBMC expressed [IL-8] in *response* to exogenous , similar to exogenous IL-1alpha and IL-1beta . Positive_regulation IL8 TNF 10873156 708352 Synergistic inhibition by beta ( 2 ) -agonists and corticosteroids on *induced* [interleukin-8] release from cultured human airway smooth-muscle cells . Positive_regulation IL8 TNF 10873156 708353 Here , we tested the effects of the beta ( 2 ) -agonists salbutamol ( Salbu ) and salmeterol ( Salme ) on IL-8 release and *induced* [IL-8] release from ASM cells . Positive_regulation IL8 TNF 10873156 708354 We found that strongly *enhanced* [IL-8] release in a time- and concentration dependent manner , whereas Salbu , Salme , the direct adenylyl cyclase activator forskolin ( FSK ) , and the cyclic monophosphate ( cAMP ) analogue 8-bromoadenosine 3',5'-cAMP ( 8-Br-cAMP ) alone weakly stimulated IL-8 release . Positive_regulation IL8 TNF 10881930 709225 The addition of IL-1beta and strongly *enhanced* [IL-8] , MCP-1 , and RANTES secretion ; Positive_regulation IL8 TNF 10919504 717240 Phenotypic features of alveolar monocytes/macrophages and [IL-8] gene *activation* by IL-1 and in asthmatic patients . Positive_regulation IL8 TNF 10958731 726184 In vitro studies demonstrated that SK-N-MC and SK-N-SH cells express low levels of [IL-8] under normal conditions and that IL-1beta and significantly *increased* expression of IL-8 at 24 and 48 hours . Positive_regulation IL8 TNF 10970832 728836 To determine whether altered signal transduction through the nuclear factor (NF)-kappaB pathway occurs in CF epithelial cells and results in excessive generation of inflammatory cytokines , we evaluated *induced* production of the NF-kappaB dependent cytokine [interleukin (IL)-8] and activation of NF-kappaB in three different human bronchial epithelial cell lines : ( 1 ) BEAS cells that express wild-type CF transmembrane conductance regulator ( CFTR ) , ( 2 ) IB3 cells with mutant CFTR , and ( 3 ) C38 cells , which are `` corrected '' IB3 cells complemented with wild-type CFTR . Positive_regulation IL8 TNF 10979965 729853 In purified eosinophils primed with granulocyte-macrophage colony stimulating factor , both and HrHRF *induced* increased secretion of [interleukin (IL) 8] . Positive_regulation IL8 TNF 11028544 739572 An enzyme linked immunoassay was used to measure levels of the anti-apoptotic cytokine [IL-8] , *induced* by . Positive_regulation IL8 TNF 11053499 745206 The addition of MCFA ( 5 mmol/L ) induced a 40 % increase in IL-1beta induced IL-8 secretion and a 35 % increase in *induced* [IL-8] secretion , respectively . Positive_regulation IL8 TNF 11053499 745208 The addition of LCFA ( 5 mmol/L ) induced a 140 % increase in IL-1beta induced IL-8 secretion and a 110 % increase in *induced* [IL-8] secretion , respectively . Positive_regulation IL8 TNF 11069245 747804 *induced* [interleukin-8] in human blood cultures discriminates neutralization by the p55 and p75 TNF soluble receptors . Positive_regulation IL8 TNF 11069245 747806 In this study , neutralization of *induced* [interleukin (IL)-8] by p75-Fc in whole human blood exhibited a U-shaped inhibition curve , whereas the TNF-soluble p55 receptor , linked to polyethylene glycol ( p55-PEG ) , exhibited a dose dependent inhibition . Positive_regulation IL8 TNF 11069245 747807 Native soluble p75 increased *induced* [IL-8] , versus a 61 % reduction by native p55 . Positive_regulation IL8 TNF 11125305 762812 *increased* both [IL-8] mRNA expression and protein production , whereas IL-1 beta slightly increased IL-8 release but did not change mRNA expression in AEC-II . Positive_regulation IL8 TNF 11156586 780624 However , the effect of N-acetylcysteine (NAC) , which acts as a precursor of glutathione ( GSH ) synthesis , on *induced* activation of p38 MAP kinase pathway and p38 MAP kinase mediated [IL-8] production by human pulmonary vascular endothelial cells has not been determined . Positive_regulation IL8 TNF 11156586 780628 To clarify these issues , we examined the effect of NAC on *induced* activation of p38 MAP kinase , MAP kinase kinase (MKK) 3 and MKK6 which are upstream regulators of p38 MAP kinase , and p38 MAP kinase mediated [IL-8] production . Positive_regulation IL8 TNF 11156586 780636 6. These results indicate that the cellular reduction and oxidation ( redox ) regulated by intracellular GSH is critical for *induced* activation of p38 MAP kinase pathway and p38 MAP kinase mediated [IL-8] production by human pulmonary vascular endothelial cells , and we emphasize that anti-oxidant therapy is an important strategy for the treatment of acute lung injury . Positive_regulation IL8 TNF 11159885 781414 Spontaneous and *stimulated* [interleukin (IL)-8] and IL-1 beta secretion and mRNA expression were assessed in HT-29 and Caco-2 intestinal epithelial cell lines in the presence of a panel of heparin and heparan sulfate disaccharides . Positive_regulation IL8 TNF 11191284 761403 [IL-8] levels in cell supernatants were *increased* by + IFNgamma , supporting the role of the epithelium in signalling between luminal factors and mucosal immune cells . Positive_regulation IL8 TNF 11252722 793973 We demonstrated that ROR alpha is expressed in human primary smooth-muscle cells and that ectopic expression of ROR alpha1 inhibits *induced* IL-6 , [IL-8] and COX-2 expression in these cells . Positive_regulation IL8 TNF 11285034 799725 Further , the treatment of endometrial carcinoma cells with inflammatory cytokines , IL-1beta and tumor necrosis factor-alpha (TNF-alpha) , demonstrated that IL-1beta and *induced* [IL-8] expression in endometrial cancer cells . Positive_regulation IL8 TNF 11321363 807079 Whereas IL-1alpha and significantly *increased* the levels of [IL-8] , C5a decreased the IL-8 production after 48 h . Positive_regulation IL8 TNF 11332087 809052 and Their time courses were similar , thus suggesting that the *induction* of [IL-8] gene expression by is probably due to the activation of NF-kappa B . Positive_regulation IL8 TNF 11342652 813846 IL-1RA and sTNFRs , accumulating under these circumstances , seem to be centrally involved in this regulatory mechanism by interfering with the IL-1beta- and *dependent* [IL-8] generation . Positive_regulation IL8 TNF 11381071 820600 IL-13 potentiated *induced* MCP-1 , but not [IL-8] secretion by cocultures . Positive_regulation IL8 TNF 11399048 823918 The role of activator protein-1 (AP-1) in *induced* [interleukin-8 (IL-8)] gene expression was evaluated . Positive_regulation IL8 TNF 11399048 823923 Overexpression of dominant negative mutants of c-Jun suppressed AP-1-driven transcription of the IL-8 promoter following stimulation by TNF-alpha , suggesting that cooperative interaction between AP-1 and NF-kappaB is essential for [IL-8] transcription in the *presence* of . Positive_regulation IL8 TNF 11403205 824897 Finally , when CF cells were grown at 27 degrees C ( a culture condition which results in transport of CF transmembrane conductance regulator , CFTR , to the cell membrane and normalization of chloride conductance ) *stimulated* production of IL-6 and [IL-8] reverted to normal . Positive_regulation IL8 TNF 11428868 831561 In this study , the roles of p38 kinase and extracellular signal regulated kinase ( ERK ) signaling pathways were investigated for IL-1beta- or *induced* [IL-8] and MCP-1 secretion by hRPE cells . Positive_regulation IL8 TNF 11441112 833438 In contrast , IFN-gamma inhibited basal and IL-1beta- , and *induced* production of [IL-8] . Positive_regulation IL8 TNF 11472980 841551 Geldanamycin inhibited *mediated* [IL-8] gene expression in A549 human respiratory epithelial cells as measured by enzyme linked immunosorbent assay and Northern blot analyses . Positive_regulation IL8 TNF 11472980 841555 These results demonstrate that geldanamycin inhibits *mediated* [IL-8] gene expression in A549 cells by inhibiting activation of the IL-8 promoter . Positive_regulation IL8 TNF 11500086 846948 and CD95 *promote* [IL-8] gene transactivation via independent elements in colon carcinoma cells . Positive_regulation IL8 TNF 11500086 846952 the first comprising approximately 500 bp of the IL-8 promotor that includes the nuclear factor kappa B (NFkappaB) , C/EBP and AP-1 sites known to be involved in *mediated* [IL-8] induction ; Positive_regulation IL8 TNF 11509622 848619 In parallel experiments involving human colonic mucosa ex vivo , LXA ( 4 ) potently attenuated *stimulated* release of the C-X-C chemokine [IL-8] , and the C-C chemokines monocyte-chemoattractant protein-1 ( MCP-1 ) and RANTES . Positive_regulation IL8 TNF 11554784 859928 *induced* the release of [IL-8] ( P < 0.01 ) and IL-6 ( P < 0.05 ) from the duodenal explants . Positive_regulation IL8 TNF 11564889 863775 Finally , we show that inhibition of HDAC activity with TSA causes an increase in both basal and *induced* expression of the NF-kappaB regulated [interleukin-8 (IL-8)] gene . Positive_regulation IL8 TNF 11597930 870320 Increased transcription of [IL-8] in endothelial cells is differentially *regulated* by and oxidized phospholipids . Positive_regulation IL8 TNF 11597930 870323 In contrast , *induced* [IL-8] mRNA synthesis was elevated at 30 minutes , peaked at 2 hours , and reached basal/undetectable levels by 6 hours . Positive_regulation IL8 TNF 11597930 870324 Actinomycin D experiments suggested that both Ox-PAPC and *regulate* the expression of [IL-8] at the transcriptional level . Positive_regulation IL8 TNF 11698246 877786 This resulted in a marked inhibition of *induced* expression of mRNA and protein for the immunoglobulin molecules intracellular adhesion molecule-1 and vascular cell adhesion molecule-1 and the chemokines growth related oncogene-alpha , monocyte chemoattractant protein-1 , [interleukin-8] , or fractalkine in MC . Positive_regulation IL8 TNF 11706938 879512 Combined application of tumor necrosis factor (TNF)-alpha and OSM synergistically enhanced IL-6 and MCP-1 production , but downregulated *induced* [IL-8] . Positive_regulation IL8 TNF 11728452 884659 Further , IkappaB-alphaM suppressed *stimulated* release of [interleukin-6 and -8] ( IL-6 and IL-8 ) . Positive_regulation IL8 TNF 11750868 889869 The pathogenic microorganisms *induced* a dose- and time dependent release of IL-1beta , IL-6 , [IL-8] , and IL-10 , whereas secretion was not elevated . Positive_regulation IL8 TNF 11764202 887905 T-614 suppressed *induced* production of IL-6 , [IL-8] , and monocyte chemoattractant protein 1 , and also reduced the accumulation of IL-6 and IL-8 mRNA in a concentration dependent manner . Positive_regulation IL8 TNF 11813164 907434 Prior to morphological signs of apoptosis , *induced* [IL-8] synthesis is abrogated by inhibition of NF-kappaB . Positive_regulation IL8 TNF 11876523 918935 Chemokines are produced in a coordinated and sequential manner , with [IL-8] and RANTES *induced* by during early stages , and MCP-1 , IP-10 , Mig , I-TAC , I-309 and MDC induced by IFN-gamma during later stages . Positive_regulation IL8 TNF 11916194 925465 The inhibition of NF-kappaB activation markedly blocked both IL-1beta- and *induced* [IL-8] and MCP-1 mRNA expression , but did not affect MMP-1 mRNA expression . Positive_regulation IL8 TNF 11936905 927959 IL-1beta and *stimulated* the secretion of [IL-8] in HT29-MTX goblet cells . Positive_regulation IL8 TNF 11989790 936371 Our results show that pleural fluid isolated human fibroblasts release [IL-8] and MCP-1 upon *stimulation* with IL-1 beta , , and LPS in both a concentration- and time dependent manner . Positive_regulation IL8 TNF 11989790 936380 *induced* a 95-fold increase in [IL-8] and an 84-fold increase in MCP-1 levels , as compared to the controls . Positive_regulation IL8 TNF 12034575 948791 In addition , IL-17 was found to synergistically enhance *induced* production of [IL-8] , Groalpha , and G-CSF . Positive_regulation IL8 TNF 12055070 951587 In contrast , ERK and p38 inhibition resulted in the accelerated degradation of the IL-8 mRNA , suggesting that in HT-29 cells , p38 and ERK contribute to *stimulated* [IL-8] secretion by intestinal epithelial cells via a posttranscriptional mechanism that involves stabilization of the IL-8 transcript . Positive_regulation IL8 TNF 12058282 952594 Correspondingly , IGF-I markedly enhanced the TNF- and *induced* NF-kappaB dependent [interleukin-8] production . Positive_regulation IL8 TNF 12060857 952837 To elucidate the mechanisms mediating the therapeutic actions of somatostatin on acute pancreatitis , we investigated how somatostatin affects the *induced* interleukin (IL)-6 and [IL-8] secretion from pancreatic myofibroblasts . Positive_regulation IL8 TNF 12126654 966059 In turn , the inhibitory influence of PDTC on radiation induced and IL-6 expression is much lower and in contrast to curcumin , it *stimulated* [IL-8] . Positive_regulation IL8 TNF 12151344 971273 Here we report that pyrrolidine dithiocarbamate ( PDTC ) not only augmented *induced* release of [IL-8] , but also mediated IL-8 expression as a single stimulus . Positive_regulation IL8 TNF 12162440 972004 Both H2O2 and significantly *increased* [IL-8] release , which was further enhanced by pre-treatment of A549 cells with TSA compared to the individual treatments . Positive_regulation IL8 TNF 12165487 972838 IL-17 enhances the *induced* IL-6 and [IL-8] secretion in human colonic subepithelial myofibroblasts . Positive_regulation IL8 TNF 12192111 980864 However , *induced* [IL-8] mRNA expression , and co-culture of TNF-alpha treated HT-29 cells with L. plantarum 299v significantly increased IL-8 mRNA expression above levels induced by TNF-alpha alone in an adhesion dependent manner . Positive_regulation IL8 TNF 12225945 987881 We examined the requirements of NF-kappaB , ERK , JNK , and p38 for *induced* transcription from the [IL-8] promoter in a human bronchial epithelial cell line . Positive_regulation IL8 TNF 12225945 987882 Using a combination of chemical and dominant negative inhibitors , we found that inhibition of NF-kappaB , ERK , and JNK , but not p38 , each decreased *induced* transcription from the [IL-8] promoter . Positive_regulation IL8 TNF 12238566 989269 Herein we determined the effects of epigallocatechin-3-gallate ( EGCG ) , a green tea derived polyphenol , on *mediated* expression of the [IL-8] gene in A549 cells . Positive_regulation IL8 TNF 12238566 989270 EGCG inhibited *mediated* [IL-8] gene expression in a dose response manner , as measured by ELISA and Northern blot analysis . Positive_regulation IL8 TNF 12238566 989271 This effect appears to primarily involve inhibition of IL-8 transcription because EGCG inhibited *mediated* activation of the [IL-8] promoter in cells transiently transfected with an IL-8 promoter-luciferase reporter plasmid . Positive_regulation IL8 TNF 12297837 991426 The increase of [interleukin 8 (IL-8)] production *induced* by in Huh 7 cells was suppressed by the coexistence of JAG1 protein . Positive_regulation IL8 TNF 12388281 1012748 10,11-Epoxy-16 : 2 also potently inhibited *induced* production of [IL-8] , a proinflammatory cytokine , by HCEC . Positive_regulation IL8 TNF 12498928 1033612 We have investigated the effects of cannabinoid agonists and antagonists on *induced* secretion of [interleukin-8] from the colonic epithelial cell line , HT-29 . Positive_regulation IL8 TNF 12498928 1033613 The less active enantiomer of WIN55212-2 , [ S(-)-[2,3-dihydro-5-methyl-3- [ ( morpholinyl ) methyl ] pyrrolo [ 1,2,3-de ] 1,4-benzoxazin-6-yl ] ( 1-naphthyl ) methanone mesylate ( WIN55212-3 ) , and the cannabinoid CB(1) receptor agonist arachidonoyl-2-chloroethylamide ( ACEA ) had no significant effect on *induced* release of [interleukin-8] . Positive_regulation IL8 TNF 12498928 1033614 We conclude that in HT-29 cells , *induced* [interleukin-8] release is inhibited by cannabinoids through activation of cannabinoid CB(2) receptors . Positive_regulation IL8 TNF 12507564 1038408 The results indicate a primary role for IL-8 in the recruitment of neutrophils into the gland , and suggest that IL-1beta and are not *necessary* for [IL-8] production and release in response to endotoxin . Positive_regulation IL8 TNF 12542924 1034158 Stimulation with *led* to a time dependent increase of [IL-8] secretion to the apical compartment resulting in a gradient between both chambers , as well as to a time dependent increase of PMN transmigration and expression of adhesion molecules . Positive_regulation IL8 TNF 12574206 1057806 We hypothesize that may *induce* [IL-8] production in endometriotic cells through nuclear factor-kappa B (NF-kappa B) activation . Positive_regulation IL8 TNF 12574206 1057811 These findings demonstrate that NF-kappa B activation is critical for *induced* [IL-8] expression in endometriotic stromal cells . Positive_regulation IL8 TNF 12585121 895569 L-1 inhibited [IL-8] mRNA expression in HSC *induced* with ( 0.25 U.mL-1 ) . Positive_regulation IL8 TNF 12585121 895570 *promoted* [IL-8] production and mRNA expression in HSC . Positive_regulation IL8 TNF 12585121 895571 Iso inhibited [IL-8] production and mRNA expression *induced* by ( 0.25 U.mL-1 ) . Positive_regulation IL8 TNF 12588703 1084943 IL-9 alone had no effect on IL-8 release , but at concentrations of > or =30 ng/ml , IL-9 significantly increased [IL-8] release *induced* by . Positive_regulation IL8 TNF 12595589 1061683 In HT29-cl19A cells , IL-10 inhibited *stimulated* [IL-8] secretion by 52 % , and EGF increased secretion by 144 % . Positive_regulation IL8 TNF 12595589 1061691 In H4 cells , TGF-beta1 and Epo inhibited *stimulated* [IL-8] secretion to control levels , and EGF increased secretion by 29 % . Positive_regulation IL8 TNF 12600818 1085041 In 16HBE14o- human bronchial epithelial cells , maximal *induced* [interleukin (IL)-8] expression depends on the activation of two distinct signaling pathways , one constituted in part by activator protein (AP)-1 and the other by nuclear factor (NF)-kappaB . Positive_regulation IL8 TNF 12628462 1067090 Nicotine significantly inhibited *induced* [IL-8] release in a concentration related manner with peak inhibition occurring at 10 ( -7 ) M ( 2.39 +/- 0.78 ng ml(-1) , n = 5 ) . Positive_regulation IL8 TNF 12634636 1068366 Interleukin-1alpha and treatments *induced* a concentration dependent increase in [interleukin-8] messenger RNA expression in both epithelial and stromal cells . Positive_regulation IL8 TNF 12646250 1069979 Ergothioneine inhibits oxidative stress- and induced NF-kappa B *activation* and [interleukin-8] release in alveolar epithelial cells . Positive_regulation IL8 TNF 12646250 1069982 The aim of this study was to determine whether ergothioneine can inhibit the hydrogen peroxide ( H ( 2 ) O ( 2 ) ) - and *mediated* activation of NF-kappa B and the release of [IL-8] in human alveolar epithelial cells ( A549 ) . Positive_regulation IL8 TNF 12646250 1069987 Both H ( 2 ) O ( 2 ) and significantly *increased* [IL-8] release , which was inhibited by pre-treatment of A549 cells with ergothioneine compared to the control untreated cells . Positive_regulation IL8 TNF 12677171 1076932 inhibition *reduces* [CXCL-8] levels but fails to prevent fibrin generation and does not improve outcome in a rabbit model of endotoxic shock . Positive_regulation IL8 TNF 12707271 1100379 Pretreatment of monocytic cells for 72 h with low TNF doses inhibited *induced* ( restimulation with a high dose ) IL-8 promoter dependent transcription as well as [IL-8] production . Positive_regulation IL8 TNF 12707271 1100384 Finally , overexpression of C/EBPbeta , but not p65 or Oct-1 , markedly prevented *induced* [IL-8] promoter dependent transcription . Positive_regulation IL8 TNF 12748056 1140862 , IL-1beta , and lipopolysaccharide *stimulated* [IL-8] production from epithelial cells in a dose- and time dependent manner , and these effects were abrogated by specific antibodies or inhibitors . Positive_regulation IL8 TNF 12753503 1090314 and IL-1beta *induced* mesothelial cell [IL-8] mRNA expression , and neutralizing anti-TNF-alpha antibody and IL-1 receptor antagonist nearly completely obliterated CoMTB induced mesothelial cell IL-8 mRNA expression and protein secretion . Positive_regulation IL8 TNF 12754109 1090427 Relative and competitive RT-PCR analysis verified downregulation of *mediated* expression of CD40L and [IL-8] by Dexa and Dexa-Ab ( hEsel ) , respectively . Positive_regulation IL8 TNF 12780691 1095581 In addition , we highlight the *role* of in [IL-8] secretion in MDR-TB patients . Positive_regulation IL8 TNF 12792762 1097836 In vitro demonstration of breast cancer tumor cell sub-populations based on *induction* of [interleukin-8] expression . Positive_regulation IL8 TNF 12792762 1097864 and TNF-beta *induced* a 3- to 24-fold increase in [IL-8] protein expression of BEC , and a 2- to 8-fold increased IL-8 expression in estrogen independent BCC cell lines and no significant IL-8 expression in estrogen dependent cell lines . Positive_regulation IL8 TNF 12797546 1098722 IL-8 release from fibroblasts was significantly increased when cultured with RBC or RBC-CM and both and interleukin-1beta (IL-1beta) further *stimulated* this [IL-8] secretion . Positive_regulation IL8 TNF 12911858 1122180 The in plasma may partially *induce* transcription of IL-6 and [IL-8] , which contribute to the CD14 independent increase in level of mRNA for IL-6 and IL 8 . Positive_regulation IL8 TNF 12919942 1157689 activation of HEMEC *resulted* in upregulation of the cell adhesion molecules (CAM) ICAM-1 , VCAM-1 , E-selectin , and mucosal addressin CAM-1 (MAdCAM-1) , increased [IL-8] production , and enhanced leukocyte binding . Positive_regulation IL8 TNF 12948934 1185434 In response to hrHRF , these cells induced [IL-8] mRNA expression within 4 h. H2O2 , but not IL-1 beta or , *stimulated* secretion of HRF p23 by BEAS-2B cells , suggesting that oxidative stress may trigger the release of HRF p23 from bronchial epithelial cells . Positive_regulation IL8 TNF 1331059 200234 These results indicated that IFN gamma synergistically enhanced *induced* [IL-8] production in a human gastric cancer cell line through synergistic activation of transcription factors without up-regulating TNF alpha receptor . Positive_regulation IL8 TNF 1409601 201411 and IL-1 are potent *inducers* of [IL-8] expression . Positive_regulation IL8 TNF 1409601 201415 Earlier we showed that *induced* stimulation of [IL-8] mRNA accumulation in human FS-4 fibroblasts was inhibited by interferon beta (IFN-beta) or IFN-gamma . Positive_regulation IL8 TNF 1409601 201418 Treatment with IFN-beta also decreased *induced* [IL-8] protein accumulation . Positive_regulation IL8 TNF 1409601 201420 Nuclear run-on assays demonstrated that IFN-beta caused a marked inhibition of *induced* [IL-8] gene transcription ; Positive_regulation IL8 TNF 1416405 201580 Because is a strong *inducer* of [IL-8] , we also asked whether TNF-alpha was present . Positive_regulation IL8 TNF 1427594 202453 at a low dose ( 10 U/ml ) *stimulated* production of prostaglandin E2 , Mn-superoxide dismutase , interleukin (IL)-6 and [IL-8] by glioblastoma cells . Positive_regulation IL8 TNF 1434539 204646 However , alpha-thrombin synergistically enhanced the PMNL infiltration *induced* by IL-1 alpha , , but not that induced by zymosan activated plasma ( C5a ) or [IL-8] ( neutrophil activating peptide-1 ) . Positive_regulation IL8 TNF 14509560 1146404 HBECs , freshly isolated from resected bronchi at the time of surgery in ex-smokers with lung cancer , constitutively expressed over 3 times more ICAM-1 than VCAM-1 ( P < 0.05 ) and secreted greater amounts of IL-8 than of GM-CSF or RANTES ( P < 0.001 ) . Stimulation of HBECs with IL-4 , TNF-alpha or IL-4 plus TNF-alpha upregulated ICAM-1 expression ( P < 0.05 ) and increased GM-CSF and [IL-8] secretion ( P < 0.05 ) . Similarly , VCAM-1 expression was significantly *increased* by IL-4 plus , while RANTES release was significantly enhanced by IL-4 or by IL-4 plus TNF-alpha ( P < 0.05 ) , but not by TNF-alpha alone ( P > 0.05 ) . Positive_regulation IL8 TNF 14522842 1148247 Attenuation of *stimulated* [IL-8] secretion by oATP was similar in wild-type HEK cells or HEK cells stably expressing recombinant P2X7R . Positive_regulation IL8 TNF 14522842 1148248 However , inhibition of P2Y1 receptors with the specific antagonist MRS2216 did not mimic the effects of oATP on *stimulated* [IL-8] secretion . Positive_regulation IL8 TNF 14596794 1160339 LPC did not augment *induction* of MCP-1 or [IL-8] . Positive_regulation IL8 TNF 1463043 206776 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL8 TNF 14657510 1218753 The effects of VIP on basal or *stimulated* production of CCL2 ( MCP-1 , monocyte chemotactic protein 1 ) , [CXCL8] [ interleukin (IL)-8 ] , IL-6 and TNF-alpha were studied by specific ELISAs ( enzyme linked immunosorbent assays ) . Positive_regulation IL8 TNF 14657869 1177342 We have shown that serine proteases in German cockroach extract increase *induced* expression of [IL-8] in human bronchial epithelial cells . Positive_regulation IL8 TNF 14657869 1177344 Cockroach proteases and PAR-2 activation synergistically increase *induced* [IL-8] transcription via activation of ERK . Positive_regulation IL8 TNF 14871353 1208156 However , type II P. gingivalis infection showed statistically higher levels of IL-1beta , [IL-8] , IL-12 and mRNA *induction* than those of control at 24 h postinfection , whereas type I P. gingivalis and A. naeslundii showed no significant induction of these cytokines . Positive_regulation IL8 TNF 15005855 1217520 Ion/PMA and *induced* [IL-8] mRNA expression . Positive_regulation IL8 TNF 15026281 1222664 Acanthoic acid suppressed *induced* [IL-8] production in a dose dependent manner . Positive_regulation IL8 TNF 15071361 1232524 Azelnidipine , a newly developed long acting calcium antagonist , inhibits *induced* [interleukin-8] expression in endothelial cells through its anti-oxidative properties . Positive_regulation IL8 TNF 15071361 1232525 In this study , we investigated whether and how azelnidipine , a newly developed long acting calcium antagonist , could inhibit *induced* [IL-8] expression in human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation IL8 TNF 15071361 1232530 An inhibitor of AP-1 , curcumin , or an anti-oxidant , N-acetylcysteine , also inhibited the *induced* [IL-8] expression in HUVEC . Positive_regulation IL8 TNF 15071361 1232532 These results demonstrated that azelnidipine inhibited *induced* [IL-8] expression in HUVEC by blocking NADPH oxidase mediated ROS generation and subsequent AP-1 activation . Positive_regulation IL8 TNF 15081568 1234162 [IL-8] release by PMN was much more strongly *induced* by , increasing by 1050 % in the presence of 10 ng/ml TNF-alpha ( P < 0.005 ) , whereas MNC or MNC/PMN subjected to this stimulus alone did not significantly enhance their IL-8 release . Positive_regulation IL8 TNF 15211029 1262156 We observed constitutive expression of interleukin (IL)-6 , [IL-8] , granulocyte macrophage colony stimulating factor ( GM-CSF ) , and monocyte chemoattractant protein (MCP)-1 in both human and baboon endothelial cells , and these cytokines were further *induced* by and LPS . Positive_regulation IL8 TNF 15322027 1286730 Epithelial cells were cultured for various times with live and killed L. reuteri and examined by reverse transcription-PCR for NGF , IL-10 , and *induced* [IL-8] expression . Positive_regulation IL8 TNF 15322027 1286731 Neither cellular lysates nor media supernatants had any effect on *induced* [IL-8] . Positive_regulation IL8 TNF 15350531 1292411 Using a novel model of EMT in colon carcinoma in which the inflammatory cytokine TNF-alpha accelerates this TGF-beta directed process , we report that stimulation *upregulates* expression of the chemokine [IL-8] , and that this upregulation is dependent on the transcription factor NF-kappaB . Positive_regulation IL8 TNF 15379213 1298200 Our study indicated that both , dexamethasone and IFN inhibit *induced* upregulation of [IL-8] at the mRNA level . Positive_regulation IL8 TNF 1545121 183476 The early , local production of and IL-1 may therefore *contribute* to the subsequent expression of [IL-8] . Positive_regulation IL8 TNF 15472211 1317964 Using ELISA , significantly *enhanced* the production of [IL-8] , growth related oncogene alpha , and epithelial neutrophil activating peptide-78 in all cases of ECSC ( n = 10 ) , ESCwE ( n = 6 ) , and , NESC ( n = 10 ) . Positive_regulation IL8 TNF 15483420 1320510 We determined the effects of theaflavin , a black tea derived polyphenol , on *mediated* expression of the [interleukin-8] gene in A549 cells . Positive_regulation IL8 TNF 15483420 1320511 A549 cells were exposed to varying concentrations of theaflavin and analyzed for *mediated* [interleukin-8] gene expression . Positive_regulation IL8 TNF 15483420 1320512 Theaflavin inhibited *mediated* [interleukin-8] gene expression , as measured by luciferase assay and Northern blot analysis , at concentrations of 10 and 30 microg/mL . Positive_regulation IL8 TNF 15483420 1320513 This effect appears to primarily involve inhibition of interleukin-8 transcription because theaflavin inhibited *mediated* activation of the [interleukin-8] promoter in cells transiently transfected with an interleukin-8 promoter-luciferase reporter plasmid . Positive_regulation IL8 TNF 15531521 1336087 Stimulation of placenta , adipose tissue , and skeletal muscle with LPS and *resulted* in greater release of IL-6 and [IL-8] , whereas only LPS increased TNF-alpha release from all three tissues . Positive_regulation IL8 TNF 15531761 1360348 We reported here that the PPARgamma agonists 15-deoxy-Delta ( 12,14 ) -PGJ ( 2 ) ( 15d-PGJ ( 2 ) ) and troglitazone , but not PPARalpha agonist WY-14643 , inhibited *induced* production of eotaxin and monocyte chemotactic protein-1 (MCP-1) but not [IL-8] . Positive_regulation IL8 TNF 1556187 184429 As expected , also *led* to the appearance of [IL-8] in the rabbit pleural space and stimulated cultured pleural mesothelial cells to synthesize and release IL-8 . Positive_regulation IL8 TNF 15576670 1368485 German cockroach extract synergistically regulates *induced* [interleukin (IL)-8] expression in human airway epithelial cells . Positive_regulation IL8 TNF 15576670 1368486 We conclude that proteases in German cockroach extract regulate PAR-2 and ERK to increase NF-IL6 activity and synergistically regulate *induced* [IL-8] promoter activity in human airway epithelium . Positive_regulation IL8 TNF 15589482 1356190 Inhibitory effect of luteolin on *induced* [IL-8] production in human colon epithelial cells . Positive_regulation IL8 TNF 15589482 1356191 In this study , we investigated the role of luteolin , a major flavonoid of Lonicera japonica , on *induced* [IL-8] production in human colonic epithelial cells . Positive_regulation IL8 TNF 15589482 1356192 Luteolin suppressed *induced* [IL-8] production in dose dependent manner . Positive_regulation IL8 TNF 15589482 1356250 These results suggest that luteolin has the inhibitory effects on *induced* [IL-8] production in the intestinal epithelial cells through blockade in the phosphorylation of MAPKs , following IkappaB degradation and NF-kappaB activation . Positive_regulation IL8 TNF 15622447 1349023 IL-8 induction by hyperforin required the activation of AP-1 but not the NF-kappaB transcription factor , thereby distinguishing it from the NF-kappaB dependent [IL-8] induction *mediated* by . Positive_regulation IL8 TNF 15622478 1349035 IL-1beta- and *induced* [IL-8] and IL-6 secretion was significantly decreased after the first and second LCAP treatments . Positive_regulation IL8 TNF 15650393 1364030 To investigate how acrolein affects respiratory tract cell activation , we exposed either primary ( NHBE ) or immortalized human bronchial epithelial cells ( HBE1 ) to 0-25 microM acrolein , and determined effects on basal and *induced* production of the chemokine [interleukin (IL)-8] . Positive_regulation IL8 TNF 15650394 1364035 Curcumin inhibited both H2O2- and mediated *activation* of NF-kappaB and AP-1 , and [IL-8] release . Positive_regulation IL8 TNF 15652492 1364239 *induces* [interleukin-8] and endothelin-1 expression in human endothelial cells with different redox pathways . Positive_regulation IL8 TNF 15652492 1364243 By Northern blot analysis , at 50 , 100 , 200 , and 400 U/ml significantly *induced* [IL-8] mRNA expression by 206 % , 252 % , 211 % , and 158 % , respectively , as compared to controls ( p < 0.05 ) . Positive_regulation IL8 TNF 15652492 1364247 Overexpression of human superoxide dismutase (SOD) by adenovirus mediated gene transfer or addition of exogenous hydrogen peroxide ( H ( 2 ) O ( 2 ) ) significantly enhanced *induced* [IL-8] mRNA expression . Positive_regulation IL8 TNF 15652492 1364255 Thus , significantly *induces* both [IL-8] and ET-1 gene expression in HMECs possibly through different redox signaling pathways . Positive_regulation IL8 TNF 15652492 1364261 H ( 2 ) O ( 2 ) enhances *induced* [IL-8] expression , but inhibits TNF-alpha induced ET-1 expression . Positive_regulation IL8 TNF 15654981 1364578 Eicosapentaenoic acid and docosahexaenoic acid reduce UVB- and *induced* [IL-8] secretion in keratinocytes and UVB induced IL-8 in fibroblasts . Positive_regulation IL8 TNF 15654981 1364579 We also explored the ability of n-3 PUFA to protect against *induction* of [IL-8] , and assessed relative potencies of the principal dietary n-3 PUFA , eicosapentaenoic acid ( EPA ) and docosahexaenoic acid ( DHA ) . Positive_regulation IL8 TNF 15654981 1364580 In addition , *induced* [IL-8] secretion by keratinocytes was reduced by 54 % and 42 % , respectively , by EPA and DHA ( p < 0.001 ) . Positive_regulation IL8 TNF 15654981 1364581 Hence both n-3 PUFA inhibit production of UVB- and *induced* [IL-8] in skin cells ; Positive_regulation IL8 TNF 15664665 1365286 The stimulatory effect of BK on the IL-1beta- or *stimulated* [IL-8] production was reduced in the presence of BK B2 receptor antagonist HOE 140 , whereas the B1 receptor antagonist Lys- ( des-arg9 , Leu8 ) -BK had no effect . Positive_regulation IL8 TNF 15664665 1365303 In conclusion , this study shows that BK upregulates IL-1beta- and *stimulated* [IL-8] production via BK B2 receptor and that PKC signal pathway seems to be involved in the upregulation of the cytokine induced IL-8 production in gingival fibroblasts . Positive_regulation IL8 TNF 15687330 1402542 Thalidomide inhibits *induced* [interleukin-8] expression in endometriotic stromal cells , possibly through suppression of nuclear factor-kappaB activation . Positive_regulation IL8 TNF 15687330 1402543 *induces* [IL-8] production in endometriotic cells through nuclear factor-kappaB (NF-kappaB) activation . Positive_regulation IL8 TNF 15687330 1402544 We examined whether Thal abrogates *induced* up-regulation of [IL-8] expression in endometriotic stromal cells . Positive_regulation IL8 TNF 15687330 1402548 and 4 ) Pretreatment with Thal reduced *induced* [IL-8] protein production as well as mRNA expression . Positive_regulation IL8 TNF 15723090 1396081 Similarly , IKK beta ( KA ) and I kappa B alpha delta N overexpression also inhibited IL-1beta- and *dependent* increases in ICAM-1 , [IL-8] and GM-CSF in addition to IL-1beta mediated increases in cyclooxygenase-2 expression , whereas IKK alpha ( KM ) overexpression had little effect on these outputs . Positive_regulation IL8 TNF 15746434 1403266 Human recombinant and IL-1alpha could *induce* [IL-8] expression in lung cancer cells in a dose dependent manner . Positive_regulation IL8 TNF 15818692 1393484 Nevertheless , the C43S TRAPS fibroblasts were capable of producing interleukin-6 (IL-6) and [IL-8] in *response* to . Positive_regulation IL8 TNF 15828923 1394274 *induced* [IL-8] secretion was also significantly decreased after apheresis , but there was no significant difference in TNF-alpha induced IL-6 secretion ( P = 0.052 ) . Positive_regulation IL8 TNF 15866594 1402055 To investigate whether and how P , dienogest ( synthetic progestin ) , and danazol affected *induced* [interleukin-8 (IL-8)] expression in endometriotic stromal cells . Positive_regulation IL8 TNF 15870903 1405526 We investigated the role of 18 beta-glycyrrhetinic acid ( GA ) , a saponin isolated from licorice roots , on *induced* [IL-8] production in human colonic epithelial cells . Positive_regulation IL8 TNF 15870903 1405527 GA suppressed *induced* [IL-8] production in a concentration dependent manner . Positive_regulation IL8 TNF 15870903 1405586 These results suggest that GA has the inhibitory effects on *induced* [IL-8] production in the intestinal epithelial cells through blockade in the phosphorylation of MAPKs , following I kappa B alpha degradation and NF-kappa B activation . Positive_regulation IL8 TNF 15893134 1407514 In the process of the search for such a unique anti-hypertensive drug , we have recently found that azelnidipine , a newly developed and commercially used long acting dihydropyridine based calcium antagonist ( DHP ) , inhibited *induced* activator protein-1 activation and [interleukin-8] expression in human umbilical vein endothelial cells by suppressing NADPH oxidase mediated reactive oxygen species generation . Positive_regulation IL8 TNF 15917841 1440333 *increased* the mRNA levels of TNFalpha itself as well as IL-6 , [IL-8] , IL-1beta and PAI-1 , but not leptin . Positive_regulation IL8 TNF 1598496 188926 Both interleukin 1 alpha (IL-1 alpha) and *stimulated* the production of [interleukin 8 (IL-8)] by synovial cells in time and dose dependent manners . Positive_regulation IL8 TNF 15987860 1429152 Alive and dead Lactobacillus rhamnosus GG decrease *induced* [interleukin-8] production in Caco-2 cells . Positive_regulation IL8 TNF 15987860 1429153 We hypothesized that Lactobacillus rhamnosus GG ( LGG ) are capable of downregulating *induced* [interleukin (IL)-8] production under all 3 of these conditions , and that LGG act through the nuclear factor kappaB (NFkappaB)/inhibitor of kappaB ( IkappaB ) pathway . Positive_regulation IL8 TNF 15987860 1429154 *induced* production of [IL-8] by Caco-2 cells was modulated by LGG under all 3 conditions . Positive_regulation IL8 TNF 15987860 1429155 Heat killed LGG also blunted the *induced* [IL-8] production ( P < 0.01 ) , but by itself did not increase IL-8 production at higher doses as markedly as live LGG ( P < 0.05 ) . Positive_regulation IL8 TNF 15987860 1429158 LGG reduced *induced* [IL-8] production by affecting the NFkappaB/IkappaB pathway in Caco-2 cells . Positive_regulation IL8 TNF 15989427 1429349 The *induced* release of interleukin-6 (IL-6) and [IL-8] was significantly inhibited by the application of siRNA . p65 . Positive_regulation IL8 TNF 16004996 1431181 Interleukin-4 downregulates *induced* [IL-8] production in keratinocytes . Positive_regulation IL8 TNF 16004996 1431182 IL-4 regulation of *induced* [IL-8] expression is cell-type specific . Positive_regulation IL8 TNF 16004996 1431184 In this study , we show that in the keratinocyte cell line HaCaT , IL-4 decreases *induced* [IL-8] mRNA expression . Positive_regulation IL8 TNF 16004996 1431185 We then investigated the mechanism of IL-4 effect and showed that IL-4 downregulates *induced* [IL-8] promoter activity in luciferase reporter assays . Positive_regulation IL8 TNF 16004996 1431188 Overall our results suggest that IL-4 regulates *induced* [IL-8] expression at a transcriptional level and this mechanism involves STAT6 and NF-kappaB transcription factors . Positive_regulation IL8 TNF 16006772 1447367 The levels of circulating interleukin (IL)-6 , [IL-8] , macrophage colony stimulating factor ( M-CSF ) and interleukin 1 receptor antagonist ( IL-1ra ) significantly *increased* with the clinical stage of CRC , and the levels of IL-6 , soluble tumor necrosis factor ( sTNF ) receptor type I ( RI ) , soluble interleukin 2 receptor alpha and with tumor grade , while IL-6 , IL-8 , M-CSF , IL-1ra and sTNF RI levels significantly rose with bowel wall invasion . Positive_regulation IL8 TNF 16029496 1441668 *enhanced* CSE induced [IL-8] release and expression . Positive_regulation IL8 TNF 16107255 1448393 Histidine inhibits oxidative stress- and *induced* [interleukin-8] secretion in intestinal epithelial cells . Positive_regulation IL8 TNF 16107255 1448394 We investigated the effect of several amino acids on the secretion of such inflammatory cytokines as [interleukin-8 (IL-8)] *induced* by hydrogen peroxide or in intestinal epithelial-like Caco-2 and HT-29 cells . Positive_regulation IL8 TNF 16107255 1448395 We found that histidine , one of the conditionally essential amino acids , significantly inhibited both hydrogen peroxide- and *induced* [IL-8] secretion and mRNA expression in Caco-2 cells and HT-29 cells . Positive_regulation IL8 TNF 16107255 1448396 *increased* the transcriptional activity of the [IL-8] promoter which was significantly inhibited by treating Caco-2 cells with histidine . Positive_regulation IL8 TNF 16107255 1448401 These results indicate that histidine inhibited the hydrogen peroxide- and *induced* [IL-8] secretion at the transcriptional level in intestinal epithelial cells , suggesting that histidine has the potential to attenuate intestinal inflammation . Positive_regulation IL8 TNF 16118510 1454378 alpha-MSH inhibited IL-1beta or *stimulated* [IL-8] and MCP-1 protein levels in the media . Positive_regulation IL8 TNF 16175346 1461826 and IL-1beta are early regulators of the immune response and both *induce* the release of secondary cytokines , such as IL-6 and [IL-8] . Positive_regulation IL8 TNF 16269654 1490067 Adiponectin also inhibited [IL-8] mRNA expression *induced* by . Positive_regulation IL8 TNF 16269654 1490068 The inhibitory effect of adiponectin on *induced* [IL-8] synthesis was inhibited by pretreatment with Rp-cAMP , a PKA inhibitor . Positive_regulation IL8 TNF 16269654 1490077 The inhibitory effect of adiponectin on TNF-alpha induced IL-8 synthesis was abrogated in part by pretreatment with the PI3 kinase inhibitor LY294002 or by Akt siRNA transfection , suggesting that Akt activation might inhibit [IL-8] synthesis *induced* by . Positive_regulation IL8 TNF 16276968 1480447 Inhibitory effect on *induced* [IL-8] production in the HT29 cell of constituents from the leaf and stem of Weigela subsessilis . Positive_regulation IL8 TNF 1628417 191785 The cytokine [IL-8] -- predominantly an activator and chemotactic factor for circulating polymorphonuclear neutrophil leucocytes -- is produced in *response* to in vitro , and high circulating levels of IL-8 are found in septic primates . Positive_regulation IL8 TNF 16326999 1503507 [IL-8] production in *response* to activation by unrelated and PMA signaling pathways is also inhibited , indicating a broad spanning tolerance . Positive_regulation IL8 TNF 16353157 1526378 We show that phenoxodiol inhibits hallmarks of endothelial cell activation , namely or IL-1 *induced* E-selectin and VCAM-1 expression and [IL-8] secretion . Positive_regulation IL8 TNF 16384711 1520058 Neutrophils from healthy volunteers ( NAC naïve ) were pre incubated with NAC for 30 min and the effects on the release of elastase and [IL-8] , the respiratory burst in response to fMLP and PMA , on induced NFkappaB *activation* and on the migration across an endothelial-epithelial bilayer were investigated . Positive_regulation IL8 TNF 16391493 1560932 These findings indicate that berberine dose-dependently inhibited the expression of [IL-8] and MCP-1 *induced* by IL-1beta or . Positive_regulation IL8 TNF 16413378 1513960 and IL-1beta ( 0.01 to 100 ng/mL ) *induced* secretion of [IL-8] , IL-6 , and RANTES in a dose and time dependent manner . Positive_regulation IL8 TNF 16427093 1554286 Metalloprotease dependent amphiregulin release mediates *induced* [IL-8] secretion in the human airway epithelial cell line NCI-H292 . Positive_regulation IL8 TNF 16427093 1554289 Since recent studies demonstrated that the stimulation of epidermal growth factor receptor (EGFR) could induce IL-8 secretion , the involvement of EGFR in *induced* [IL-8] secretion in airway epithelium-like NCI-H292 cells was investigated in this study . Positive_regulation IL8 TNF 16427093 1554292 and epidermal growth factor (EGF) *stimulated* [IL-8] secretion in a time- and concentration dependent manner . Positive_regulation IL8 TNF 16427093 1554294 Inhibition of the EGFR by either an anti-EGFR neutralizing antibody or by its specific inhibitor AG1478 ( 1 microM ) blocked *induced* [IL-8] secretion . Positive_regulation IL8 TNF 16427093 1554297 Further , *induced* [IL-8] secretion was completely inhibited by the neutralizing antibody against amphiregulin (AR) , an EGFR ligand , suggesting that TNF-alpha induced IL-8 secretion was mediated by the AR-EGFR pathway . Positive_regulation IL8 TNF 16427093 1554298 Finally , both AR and [IL-8] release *induced* by were eliminated by pretreatment with either GM6001 , a broad-spectrum inhibitor for metalloprotease , or TAPI-1 , relatively selective inhibitor for TNF-alpha converting enzyme (TACE) . Positive_regulation IL8 TNF 16427093 1554299 These findings indicate that metalloprotease mediated AR shedding and subsequent activation of EGFR play a critical role in *induced* [IL-8] secretion from the human airway epithelium-like NCI-H292 cells , and that TACE is one of the most possible candidates for metalloprotease responsible for TNF-alpha induced AR shedding . Positive_regulation IL8 TNF 16499908 1554951 Disruption of microtubule structure with vinblastin and of actin with cytochalasin D did not affect *induced* IL-6 and [IL-8] gene transcription but stabilized IL-8 and IL-6 mRNA . Positive_regulation IL8 TNF 16610017 1545261 VacA alone *induced* expression of TNF-alpha , [IL-8] and IL-1beta , while NaCl alone induced expression of and IL-1beta . Positive_regulation IL8 TNF 16619004 1569171 These findings suggest that or IL-1beta primed HSCs *enhance* the production of [IL-8] in response to PGN and LTA through augmentation of the TLR2 system . Positive_regulation IL8 TNF 16684953 1560078 Here , we perform an in vitro study to show that although IL-17A did not induce secretion of the CXC chemokine IL-8 from ASM cells , IL-17A significantly potentiates *induced* [IL-8] protein secretion and gene expression in a concentration- and time dependent manner ( P < 0.05 ) . Positive_regulation IL8 TNF 16684953 1560086 We found that IL-17A significantly augmented *induced* [IL-8] mRNA stability . Positive_regulation IL8 TNF 16684953 1560088 Collectively , these results demonstrate that IL-17A amplifies the synthetic function of ASM cells , acting via a p38 MAPK dependent posttranscriptional pathway to augment *induced* secretion of the potent neutrophil chemoattractant [IL-8] from ASM cells . Positive_regulation IL8 TNF 16740161 1585309 In addition , CpG synergistically upregulated *induced* [IL-8] expression . Positive_regulation IL8 TNF 16776679 1573094 IL-6 , [IL-8] , MCP-1 , RANTES and eotaxin were detected from fibroblasts cultures , and were all *up-regulated* by . Positive_regulation IL8 TNF 16794257 1631620 Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced *induced* [IL-8] and monocyte chemoattractant protein (MCP)-1 ( also called CCL2 ) expression in cultured human airway epithelial cells . Positive_regulation IL8 TNF 16794257 1631648 Quercetin also inhibited *induced* PI 3-kinase activity , Akt phosphorylation , intracellular H ( 2 ) O ( 2 ) production , NF-kappaB transactivation , [IL-8] promoter activity , and steady-state mRNA levels , consistent with the notion that quercetin inhibits chemokine expression by attenuating NF-kappaB transactivation via a PI 3-kinase/Akt dependent pathway . Positive_regulation IL8 TNF 16806476 1666031 *induced* [IL-8] promoter activation that is inhibited by saxatilin treatment was dependent on activating protein-1 (AP-1) instead of nuclear factor-kappa B (NF-kappaB) . Positive_regulation IL8 TNF 1681733 169050 In keeping with these biological activities and protein data , Northern blot analysis of total cellular RNA extracted from keratinocyte monolayers hybridized with a 32P labelled 1-kb cDNA to IL-8 mRNA , revealed induction of the [IL-8] gene in the *presence* of and IL-1 beta , but not IFN-gamma . Positive_regulation IL8 TNF 16871430 1613626 Pharmacologic inhibition of NF-kappaB activity significantly reduced basal IL-8 expression and *induced* [IL-8] expression ( P < 0.05 for both ) , yet NF-kappaB activity was not dependent on Src . Positive_regulation IL8 TNF 16937467 1609115 DA-9601 , a standardized extract of Artemisia asiatica , blocks *induced* [IL-8] and CCL20 production by inhibiting p38 kinase and NF-kappaB pathways in human gastric epithelial cells . Positive_regulation IL8 TNF 16937467 1609118 Treatment of AGS cells with DA-9601 reduced *induced* [IL-8] and CCL20 promoter activities , as well as their gene expression and protein release . Positive_regulation IL8 TNF 16979119 1616910 Clinically relevant concentrations of fenretinide ( 1.25 , 2.5 and 5 microM ) inhibited *induced* [IL-8] production of CF cells by up to 73 % but had no effect or increased the IL-8 production in non-CF cells . Positive_regulation IL8 TNF 17012372 1674161 and IL-1beta *increased* IL-6 and [IL-8] 12- to 67-fold with higher levels in IB3 than C38 cells post-TNF-alpha ( P < 0.05 ) . Positive_regulation IL8 TNF 17072061 1637716 NAC inhibited the beta *stimulated* ICAM-1 expression and [IL-8] release from both cell lines in a concentration dependent manner . Positive_regulation IL8 TNF 17082637 1643372 We found that short interfering RNA mediated silencing of FRA-1 enhances *induced* [IL-8] expression , whereas overexpression causes an opposite effect . Positive_regulation IL8 TNF 17108260 1686001 In contrast to these studies , we found that IFNgamma ( 1000 U/ml ) markedly inhibited *induced* expression of interleukin (IL)-6 , [IL-8] , and eotaxin by 66.29+/-3.33 , 43.86+/-7.11 , and 63.25+/-6.46 % , respectively . Positive_regulation IL8 TNF 17108260 1686003 These genes were also found to be NF-kappaB dependent in that *induced* expression of IL-6 , [IL-8] , and eotaxin was dose-dependently inhibited by the selective IKKbeta inhibitor 4- ( 2'-aminoethyl ) amino-1,8-dimethylimidazo [ 1,2-a ] quinoxaline ( BMS-345541 ) ( 1-30 microM ) . Positive_regulation IL8 TNF 17177974 1679696 This factor ( s ) in the bacterial culture supernatant inhibited both basal and *induced* [IL-8] production . Positive_regulation IL8 TNF 17178392 1679720 Simvastatin ( 50 micro M ) significantly inhibited *induced* [IL-8] gene expression in COLO 205 cells . Positive_regulation IL8 TNF 17207890 1724698 An AP-1 and a NF-kappaB recognition sites were necessary for full *induction* of [IL-8] promoter activity by and TPA . Positive_regulation IL8 TNF 17273796 1691776 However , it was unknown whether curcumin , showing inhibitory effects on NF-kappaB and MAPKs , attenuates the expression of *induced* IL-1beta , IL-6 , [IL-8] , and TNF-alpha as well as cyclin E expression in HaCaT cells . Positive_regulation IL8 TNF 17273796 1691779 We found that curcumin inhibited the expression of *induced* IL-1beta , IL-6 , and TNF-alpha , but not [IL-8] , in TNF-alpha treated HaCaT cells as well as the TNF-alpha induced cyclin E expression . Positive_regulation IL8 TNF 1729366 180970 By using a specific RIA , we demonstrate that not only IL-1 beta , but also and LPS can *induce* abundant [IL-8] secretion from chondrocytes . Positive_regulation IL8 TNF 17295217 1718763 Furthermore , UTP had no effect on interleukin-(IL)-8 release and reduced the release of both CCL20 and [IL-8] *induced* by and LPS . Positive_regulation IL8 TNF 17306937 1705210 The role of sphingosine 1-phosphate in the *induction* of [IL-8] gene expression in lung epithelial cells . Positive_regulation IL8 TNF 17306937 1705212 [Interleukin-8 (IL-8)] , a C-X-C chemokine , is *induced* by and initiates injury by acting as a chemoattractant for neutrophils and other immune cells . Positive_regulation IL8 TNF 17306937 1705213 Although sphingolipids such as ceramide and sphingosine 1-phosphate (S1-P) have been shown to serve as signaling molecules in the TNF-alpha inflammatory response , their role in the *induction* of [IL-8] gene expression in lung epithelial cells is not known . Positive_regulation IL8 TNF 17306937 1705214 We investigated the role of sphingolipids in the *induction* of [IL-8] gene expression in H441 lung epithelial cells . Positive_regulation IL8 TNF 17306937 1705216 We found that *induced* [IL-8] mRNA levels by increasing gene transcription , and the stability of IL-8 mRNA was not affected . Positive_regulation IL8 TNF 17306937 1705221 Dimethylsphingosine , an inhibitor of sphingosine kinase , partially inhibited *induction* of [IL-8] mRNA levels indicating the importance of intracellular increases in S1-P in the IL-8 induction . Positive_regulation IL8 TNF 17306937 1705231 These data show that increases in the intracellular S1-P partly mediate *induction* of [IL-8] gene expression in H441 lung epithelial cells via ERK and p38 MAPK signaling pathways and increased AP-1 DNA binding . Positive_regulation IL8 TNF 17307163 1705289 Synergistic effect of PGD2 via prostanoid DP receptor on *induced* production of MCP-1 and [IL-8] in human monocytic THP-1 cells . Positive_regulation IL8 TNF 17307163 1705296 In addition , the selective prostanoid DP receptor antagonist , pinagladin ( ( Z ) -7- [ ( 1R,2R,3S,5S ) -2- ( benzothiophen-3-ylcarbonylamide ) -10-norpinan-3-yl ] hept-5-enoic acid ) inhibited the production of MCP-1 and [IL-8] upon combined *stimulation* with PGD2 and . Positive_regulation IL8 TNF 17307163 1705312 Our findings suggest that activation of the prostanoid DP receptor on THP-1 cells enhances *induced* MCP-1 and [IL-8] production via the cAMP/PKA signaling pathway . Positive_regulation IL8 TNF 17314215 1740840 The production of IL-1beta , IL-6 and [IL-8] *induced* by was decreased by pyrrolidine dithiocarbamate ( PDTC ) , a chemical inhibitor of NF-kappaB . Positive_regulation IL8 TNF 17314215 1740845 *induced* production of IL-1beta , IL-6 and [IL-8] was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002 , suggesting that inhibition of Akt activation might inhibit IL-1beta , IL-6 and IL-8 production induced by TNF-alpha . Positive_regulation IL8 TNF 17317104 1747545 Consistently , a site mutation of Rel A ( Ser ( 276 ) to Ala ) in RelA-deficient embryonic fibroblasts failed to activate [IL-8] Luciferase activity in *response* to . Positive_regulation IL8 TNF 17317104 1747549 These results indicate that the ROS mediated *induced* [IL-8] transcription is regulated by NF-kappaB/RelA phosphorylation at the critical Ser ( 276 ) residue by PKAc , resulting in stable enhanceosome formation on target genes . Positive_regulation IL8 TNF 17389616 1748471 Additionally , t10 , c12-CLA and tt-CLA inhibited *induced* [IL-8] from 11 669 +/- 1692 pg/ng protein in control cells to 5540 +/- 191 ( P < 0.001 ) and 8082 +/- 1298 pg/ng ( P < 0.01 ) protein , respectively . Positive_regulation IL8 TNF 17418999 1748777 Exogenous LXA ( 4 ) significantly inhibited *induced* [interleukin-8 (IL-8)] release in the different epithelial cell types and the potency of inhibition was dependent of the accessibility of the specific LXA(4) receptor , formyl-peptide receptor like-1 (FPRL-1) expressed by all these cells . Positive_regulation IL8 TNF 17448181 1729941 The anti-inflammatory activities of adiponectin include inhibition of IL-6 and *induced* [IL-8] formation , as well as induction of the anti-inflammatory cytokines IL-10 and IL-1 receptor antagonist . Positive_regulation IL8 TNF 17461497 1731612 Lactobacillus plantarum inhibits epithelial barrier dysfunction and [interleukin-8] secretion *induced* by . Positive_regulation IL8 TNF 17461497 1731614 *Induction* of epithelial barrier dysfunction and [IL-8] secretion by is inhibited by L. plantarum . Positive_regulation IL8 TNF 17555752 1865874 Peroxisome proliferator activated receptor-gamma ligand reduced *induced* [interleukin-8] production and growth in endometriotic stromal cells . Positive_regulation IL8 TNF 17555752 1865875 To evaluate the influence of peroxisome proliferator activated receptor-gamma ( PPAR gamma ) ligand ( pioglitazone ) on *induced* [interleukin-8 (IL-8)] expression in endometriotic stromal cells ( ESCs ) and on proliferation of ESCs . Positive_regulation IL8 TNF 17555752 1865876 Measurement of IL-8 protein by ELISA showed that adding ( 100 pg/mL ) significantly *increased* [IL-8] protein . Positive_regulation IL8 TNF 17555752 1865877 Treating ESCs with 0.1-10 microM of pioglitazone significantly reduced the *induced* [IL-8] production . Positive_regulation IL8 TNF 17558435 1773938 In the absence of agonist , SR144528 by itself reduced *induced* [IL-8] release . Positive_regulation IL8 TNF 17558435 1773939 Stimulation of the dominant CB(2) receptor signalling pathway diminished cAMP accumulation and *induced* [IL-8] release . Positive_regulation IL8 TNF 17671691 1777123 *Induction* of [interleukin-8] ( CXCL-8 ) by and leukemia inhibitory factor in pancreatic carcinoma cells : Impact of CXCL-8 as an autocrine growth factor . Positive_regulation IL8 TNF 17678632 1781204 Pretreatment of human intestinal epithelial HT-29 cells with TMMC also significantly inhibited the [IL-8] and extracellular matrix metalloproteinase-7 levels *induced* by . Positive_regulation IL8 TNF 17711487 1794621 To investigate this , we studied the effect of two glucocorticoids ( dexamethasone and triamcinolone acetonide ) on reducing lipopolysaccharide (LPS)- and *induced* [interleukin (IL)-8] release in a monocytic cell line and two lymphocytic cell lines ( HUT-78 and Jurkat ) . Positive_regulation IL8 TNF 17711487 1794622 The effect of the histone deacetylase inhibitor trichostatin A (TSA) on LPS- and *induced* [IL-8] release and its repression by glucocorticoids was also examined . Positive_regulation IL8 TNF 17711487 1794625 LPS and *induced* [IL-8] release in all three cell lines and this induction was inhibited by both dexamethasone and triamcinolone . Positive_regulation IL8 TNF 17784835 1790514 In agreement with this observation , induction of [interleukin-8 (IL-8)] in *response* to was seen only in differentiated SNUhES3 cells . Positive_regulation IL8 TNF 17784835 1790516 On the basis of an IkappaB kinase (IKK) inhibitor study , expression of [IL-8] *induced* by was dependent on NF-kappaB activity . Positive_regulation IL8 TNF 17854477 1795900 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving *dependent* [interleukin-12] induction . Positive_regulation IL8 TNF 17891168 1818800 Similarly , H ( 3 ) and H ( 4 ) receptor agonists did not affect *induced* NF-kappaB dependent transcription , or IL-6 and [IL-8] release at concentrations below 10 microM . Positive_regulation IL8 TNF 17916596 1819307 In vitro analyses revealed a striking *induction* of [IL-8] expression in CAFs and LFs by . Positive_regulation IL8 TNF 17916596 1819308 *induced* up-regulation of [IL-8] via nuclear factor-kappaB in CAFs is an inflammatory pathway , potentially permissive for cancer invasion that may represent a novel therapeutic target . Positive_regulation IL8 TNF 17959901 1814994 Stimulation of gingival fibroblasts with , IL-1alpha , and lipopolysaccharide markedly induced IL-8 production , and the [IL-8] production was synergistically *augmented* in the presence of or pre-treatment with histamine . Positive_regulation IL8 TNF 17967864 1844843 To determine the effect of E. coli Nissle 1917 , the human colonic epithelial cell line HCT15 was incubated with or without E. coli Nissle 1917 or another nonpathogenic E. coli strain , K-12 , and then *induced* [interleukin-8 (IL-8)] production from HCT15 cells was assessed . Positive_regulation IL8 TNF 17967864 1844844 Enzyme linked immunosorbent assays and real-time quantitative PCR showed that Nissle 1917 treatment suppressed *induced* [IL-8] transcription and production . Positive_regulation IL8 TNF 17967864 1844845 In conclusion , these data indicate that the nonpathogenic E. coli strain Nissle 1917 expresses a direct anti-inflammatory activity on human epithelial cells via a secreted factor which suppresses *induced* [IL-8] transactivation through mechanisms different from NF-kappaB inhibition . Positive_regulation IL8 TNF 17996674 1821722 Moreover , *induced* expression of cytokines , such as TNF-alpha and IL-1beta , and a chemokine , [IL-8] , were suppressed by silymarin treatment in human keratinocyte cell line , HaCaT . Positive_regulation IL8 TNF 18080320 1894778 These effects were mirrored by enhancement of c-Fos and inhibition of [IL-8] *induction* by . Positive_regulation IL8 TNF 18202320 1883812 FIR radiation also inhibited *mediated* expression of E-selectin , vascular cell adhesion molecule-1 , intercellular cell adhesion molecule-1 , monocyte chemoattractant protein-1 , [interleukin-8] , and the cytokine mediated adhesion of monocytes to ECs . Positive_regulation IL8 TNF 18252806 1895868 Interestingly , MEK , p38 , and IKK inhibitors block *induced* [IL-8] , IL-6 , and GM-CSF secretion and 12z invasion , whereas the PI3K inhibitors do not . Positive_regulation IL8 TNF 18255343 1877296 *induced* upregulation of the expression of inflammatory genes [interleukin (IL)-8] and intracellular adhesion molecule (ICAM)-1 was attenuated by incubation with DHEAS . Positive_regulation IL8 TNF 18325031 1898025 We examined the inhibitory effects of montelukast on *induced* [IL-8] production in PMA differentiated U-937 cells . Positive_regulation IL8 TNF 18325031 1898026 The effect of signalling pathways on *induced* [IL-8] release was examined pharmacologically using selective NF-kappaB/IKK2 ( AS602868 , 3 microm ) , ( PD98059 , 10 microm ) and p38 mitogen activated protein kinase (MAPK) ( SB203580 , 1 microm ) inhibitors . Positive_regulation IL8 TNF 18325031 1898027 Montelukast induced a concentration dependent inhibition of *induced* [IL-8] release and mRNA expression that reached a plateau at 0.1 microm without affecting cell viability . Positive_regulation IL8 TNF 18325031 1898028 Montelukast inhibits *stimulated* [IL-8] expression through changes in NF-kappaB p65 associated HAT activity . Positive_regulation IL8 TNF 18359891 1906374 Overexpression of SP-D by adenoviral mediated gene transfer in HCASMCs inhibited both LPS- and *induced* [IL-8] release . Positive_regulation IL8 TNF 18367728 1932143 HS markedly enhanced *induced* [IL-8] secretion in human A549 respiratory epithelial-like cells and in primary human small airway epithelial cells . Positive_regulation IL8 TNF 18367728 1932144 Furthermore , depletion of HSF-1 using siRNA also reduced the effects HS on *induced* [IL-8] expression , demonstrating that HSF-1 could also act to regulate IL-8 gene transcription . Positive_regulation IL8 TNF 18433103 1920792 However , steviol ( 0.01-0.2 mM ) significantly suppressed *induced* [IL-8] release in all three cell lines . Positive_regulation IL8 TNF 18433103 1920793 Two biological effects of steviol in the colon are demonstrated for the first time : stimulation of Cl ( - ) secretion and attenuation of *stimulated* [IL-8] production . Positive_regulation IL8 TNF 18444659 1915670 5-caffeoylquinic acid and caffeic acid down-regulate the oxidative stress- and *induced* secretion of [interleukin-8] from Caco-2 cells . Positive_regulation IL8 TNF 18444659 1915671 We investigated in this study the down-regulative effects of 5-caffeoylquinic acid ( CQA ) , the predominant isomer of CHA , on the H ( 2 ) O ( 2- ) or *induced* secretion of [interleukin (IL)-8] , a central pro-inflammatory chemokine involved in the pathogenesis of inflammatory bowel diseases , in human intestinal epithelial Caco-2 cells . Positive_regulation IL8 TNF 18444659 1915672 Both CQA and CA suppressed the *induced* [IL-8] secretion as well . Positive_regulation IL8 TNF 18444659 1915673 However , CQA and CA did not suppress the *induced* increase in the [IL-8] mRNA expression , indicating that the suppressive mechanisms are different between TNF-alpha induced and H ( 2 ) O ( 2 ) -induced IL-8 production models . Positive_regulation IL8 TNF 18475720 407268 Initial studies demonstrated that *induced* the upregulation of [IL-8] and MCP-1 mRNA and protein . Positive_regulation IL8 TNF 18475727 407269 [IL-8] *induction* by was , unlike its induction by LPS , resistant to the inhibitory effects of IL-10 , IL-4 , IL-13 and TGFbeta . Positive_regulation IL8 TNF 18475727 407273 Despite the capacity of IL-4 , IL-10 , and IL-13 to limit the production of *induced* [IL-8] in a whole blood assay , none was able to inhibit this production when studying isolated human polymorphonuclear cells . Positive_regulation IL8 TNF 18486623 1927688 Post-transcriptional regulation of *induced* expression of ICAM-1 and [IL-8] in human lung microvascular endothelial cells : an obligatory role for the p38 MAPK-MK2 pathway dissociated with HSP27 . Positive_regulation IL8 TNF 18486623 1927720 We evaluated the role of p38 MAPK , MK2 and HSP27 in regulating the *induced* expression of ICAM-1 and [IL-8] in human lung MVECs . Positive_regulation IL8 TNF 18486623 1927836 Our study demonstrates for the first time that MK2 mediates post-transcriptional regulation by p38 MAPK of the *induced* expression of ICAM-1 and [IL-8] in human lung MVECs , and that this regulation by the p38 MAPK/MK2 pathway is dissociated from HSP27 phosphorylation . Positive_regulation IL8 TNF 18544909 1923584 Production of [IL-8] in THP-1 cells *following* contact allergen stimulation via mitogen activated protein kinase activation or production . Positive_regulation IL8 TNF 18544909 1923598 In conclusion , IL-8 production was predominantly induced in THP-1 cells following allergen stimulation , and MAPK pathways and were *involved* in the [IL-8] production induced by DNCB and NiSO ( 4 ) . Positive_regulation IL8 TNF 18571457 1940833 Systematic analysis highlights the key *role* of kinase signaling for [IL-8] induction by macrophage-like THP-1 cells under influence of Borrelia burgdorferi lysates . Positive_regulation IL8 TNF 18611594 290018 IL-1alpha and *induce* the secretion of IL-6 and [IL-8] and the upregulation of mRNAs for IL-1alpha , IL-1beta , IL-6 and IL-8 . Positive_regulation IL8 TNF 18653246 1954840 This [CXCL8] production was *dependent* on MDM IL-1beta and production following viral and immune activation . Positive_regulation IL8 TNF 18728240 1975256 In a cellular model of colitis using tumor necrosis factor (TNF)-alpha stimulated HT29 colon epithelial cells , treatment with CLT significantly suppressed mediated [IL-8] *induction* and NF-kappaB transcriptional activity revealed by a luciferase reporter gene assay . Positive_regulation IL8 TNF 18789311 1980746 In the present study , we demonstrated that reorganization of actin cytoskeleton induced by Cytochalasin D ( CytD ) , an actin-polymerization inhibitor , enhanced [il-8] gene expression *induced* by and LPS in HL-60 monocyte-like cells . Positive_regulation IL8 TNF 18808711 1969869 Our results demonstrated that , in human pulmonary alveolar epithelial cells , the overexpression of PBEF significantly augmented basal and *stimulated* [IL-8] secretion by more than 5 to 10-fold and increased cell permeability by > 30 % ; Positive_regulation IL8 TNF 18808711 1969870 the knockdown of PBEF expression with siRNA significantly inhibited basal and *stimulated* IL-8 secretion by 70 % and [IL-8] mRNA levels by 74 % . Positive_regulation IL8 TNF 18978040 2015148 CF and non-CF cell lines produced similar levels of IL-8 at baseline and equally increased [IL-8] secretion in *response* to IL-1beta , , and the Toll-like receptor 2 agonist Pam3Cys . Positive_regulation IL8 TNF 19000754 2016055 CA , but not Michael-inactive derivatives , inhibited NF-kappaB transcriptional activity and *induced* [IL-8] production in A375 cells . Positive_regulation IL8 TNF 19029040 2035155 *induction* of [IL-8] secretion was also increased by ATPgammaS , UTP , and UDP . Positive_regulation IL8 TNF 19029040 2035162 ATPgammaS , UTP , and UDP stimulate both basal and *induced* [IL-8] secretion in RPE cells through an ERK 1/2 dependent pathway . Positive_regulation IL8 TNF 19032233 1998451 *induced* GRO-alpha and [IL-8] were slightly attenuated by DEX treatment ( reaches to 89 % and 79 % , respectively ) , whereas expressions of IP-10 , ICAM-1 and VCAM-1 were significantly enhanced by the same treatment ( up to 172 % , 152 % and 139 % , respectively ) . Positive_regulation IL8 TNF 1906912 164263 Thus , in primate bacteremia , early release is *followed* by a concomitant increase of [NAP-1/IL-8] with plasma kinetics similar to those of IL-6 and IL-1 and accompanied by massive activation of neutrophils . Positive_regulation IL8 TNF 19109405 2042209 Although both and IFN-gamma *increased* [IL-8] synthesis and CD58 expression by the HT-29 cells , only IFN-gamma reduced IL-8 production by IELs . Positive_regulation IL8 TNF 19170965 2027674 *induced* significantly increased levels of [IL-8] and TNF-alpha itself in both cell lines suggesting recruitment and activation of immune cells in the underlying mucosa in vivo . Positive_regulation IL8 TNF 1918068 168363 As in other epithelium , markedly *increased* the level of the 1.8-kilobase [IL-8] mRNA transcripts in both bronchial epithelial cell lines . Positive_regulation IL8 TNF 1918068 168364 The half-life of IL-8 mRNA transcripts in these cells was approximately 40 min and did not change after TNF stimulation , suggesting that *up-regulated* [IL-8] gene expression mainly at the transcriptional level . Positive_regulation IL8 TNF 19185976 2194753 Two-way ANOVA analysis showed that alone ( p < 0.001 ) or Mox-LDL alone ( p < 0.001 ) *increased* [IL-8] production . Positive_regulation IL8 TNF 19225413 2039890 strongly *increased* the production of CCL2 , CCL5 , and [CXCL8] ; Positive_regulation IL8 TNF 19239157 2040500 Taurine also inhibited the *induced* secretion of [IL-8] ( a human homologue of MIP-2 ) from human intestinal epithelial Caco-2 cells . Positive_regulation IL8 TNF 19258275 2062903 The *induced* production of [IL-8] was synergistically augmented by SLIGKIV-NH ( 2 ) , and that synergistic increase in the production of IL-8 was suppressed by 100 nM PAR2-specific small interfering RNA . Positive_regulation IL8 TNF 19265173 2157096 A P2X ion channel triggered NF-kappaB pathway enhances *induced* [IL-8] expression in airway epithelial cells . Positive_regulation IL8 TNF 19286927 2063853 Ceramide dependent PP2A regulation of *induced* [IL-8] production in respiratory epithelial cells . Positive_regulation IL8 TNF 19286927 2063857 *stimulates* [IL-8] production in respiratory epithelial cells by activating both the NF-kappaB and MAP kinase pathways . Positive_regulation IL8 TNF 19286927 2063861 Inhibition of PP2A using okadaic acid or gene knockdown using siRNA resulted in an augmentation of *induced* [IL-8] production . Positive_regulation IL8 TNF 19307749 2086979 Repression of *induced* [IL-8] expression by the glucocorticoid receptor-beta involves inhibition of histone H4 acetylation . Positive_regulation IL8 TNF 19307749 2086980 We investigated the functional role of GRbeta expression in the suppressive effect of glucocorticoids on *induced* [IL-8] release in an airway epithelial cell line . Positive_regulation IL8 TNF 19307749 2086981 The suppressive effect of dexamethasone on TNF-alpha induced IL-8 transcription was not affected by GRbeta overexpression , rather GRbeta had its own weak suppressive activity on *induced* [IL-8] expression . Positive_regulation IL8 TNF 1931078 169955 PF-derived [IL-8] expression was *dependent* upon stimulation by either or IL-1 but not lipopolysaccharide (LPS) . Positive_regulation IL8 TNF 19360326 2058304 We demonstrated inhibition of *induced* gene expression and release of [IL-8] and HO-1 in human monocytic THP-1 cells exposed to both volatile anesthetics . Positive_regulation IL8 TNF 1937574 170349 IL-1 and *induction* of [IL-8] and monocyte chemotactic and activating factor ( MCAF ) mRNA expression in a human astrocytoma cell line . Positive_regulation IL8 TNF 1937574 170350 Several human astrocytoma and glioblastoma cell lines expressed high levels of [IL-8] and MCAF mRNA in vitro upon *stimulation* with IL-1 and . Positive_regulation IL8 TNF 1937574 170356 These data suggest that IL-1 and *induce* astrocytes to produce [IL-8] and MCAF transcriptionally and post-transcriptionally , both of which may be responsible for leucocytosis seen in inflammation of the CNS . Positive_regulation IL8 TNF 19376732 2081865 *induced* [IL-8] expression in gastric epithelial cells : role of reactive oxygen species and AP endonuclease-1/redox factor (Ref)-1 . Positive_regulation IL8 TNF 19376732 2081866 As redox factor-1 (Ref-1) , is an important mediator of redox regulated gene expression we investigated whether ROS and Ref-1 modulate *induced* [IL-8] expression in human gastric epithelial cells . Positive_regulation IL8 TNF 19376732 2081869 Overexpression of Ref-1 enhanced IL-8 gene transcription at baseline and after TNF-alpha treatment whereas Ref-1 suppression and antioxidant treatment inhibited *stimulated* [IL-8] expression . Positive_regulation IL8 TNF 19404936 2075167 Specific alpha7nAChR agonists reduced alpha *induced* IL-6 and [IL-8] production by FLS . Positive_regulation IL8 TNF 19434061 2096507 Endogenous and *induced* expressions of IL-6 , [IL-8] , p38 , p65 and C/EBP-beta were also downregulated by genistein , showing its anti-inflammatory properties . Positive_regulation IL8 TNF 19447972 2078705 Among the 4 lactobacilli studied , Lactobacillus rhamnosus OLL2838 most effectively suppressed barrier impairment and increased [IL-8] secretion *induced* by in Caco-2 cells ; Positive_regulation IL8 TNF 19464389 2101874 Hirsutenone attenuated the *induced* production of cytokine [IL-8] , prostaglandin E ( 2 ) and chemokine CCL27 , and the formation of reactive oxygen/nitrogen species in keratinocytes . Positive_regulation IL8 TNF 19470239 2085324 Inhibitory effects of flavonoids on *induced* [IL-8] gene expression in HEK 293 cells . Positive_regulation IL8 TNF 19489038 2128381 We first determined that the C/EBPbeta-C overexpression or siRNA mediated C/EBPbeta depletion decreased *induced* promoter activities of Bfl-1 , IL-6 , and [IL-8] genes . Positive_regulation IL8 TNF 19503841 2091980 Secretion of [IL-8] from Hela cells infected with C. trachomatis was not *dependent* on IL-1 beta and induction . Positive_regulation IL8 TNF 19559500 2216626 Lidocaine inhibited spontaneous and *induced* secretion of [IL-8] and IP-10 . Positive_regulation IL8 TNF 19574047 2111376 These inhibitors were evaluated for their ability to inhibit the p38alpha enzyme , the secretion of TNFalpha in a LPS challenged THP1 cell line and *induced* production of [IL-8] in 50 % human whole blood . Positive_regulation IL8 TNF 19575800 2111554 For both NCI-H292 and NHBE cells , low arginine concentrations enhanced basal epithelial IL-6 and IL-8 production and synergized with *induced* IL-6 and [IL-8] production . Positive_regulation IL8 TNF 19607809 2123913 Both OA-NO ( 2 ) and LNO ( 2 ) prevented *stimulated* release of the cytokines , IL-6 , [IL-8] , IL-12/p40 , IFNgamma , MCP-1 , and IP-10 , and inhibited NF-kappaB activation . Positive_regulation IL8 TNF 19636295 2124547 In FOXO3 silenced HT-29 cells , *induced* [IL-8] expression is increased approximately 83 % . Positive_regulation IL8 TNF 19636295 2124548 In summary , inactivates FOXO3 in intestinal epithelia through the PI3K and IKK pathways and FOXO3 inactivation *leads* to the upregulation of [IL-8] in vitro ; Positive_regulation IL8 TNF 19648110 2138341 Repression of *induced* p38 MAPK phosphorylation , NF-kappaB dependent transcription , and [IL-8] expression by dexamethasone are sensitive to transcriptional or translational inhibitors . Positive_regulation IL8 TNF 19648110 2138410 Thus , MKP-1 attenuates *dependent* activation of p38 MAPK , induction of [IL-8] expression , and NF-kappaB dependent transcription . Positive_regulation IL8 TNF 19671412 2119503 ( 1 microg/L ) strongly *induced* the production of IL-6 and [IL-8] as compared with the control serum in A549 cells , and the induced cytokine production was significantly suppressed by 15 % serum containing Feiyanning Decoction ( P < 0.01 ) . Positive_regulation IL8 TNF 19671412 2119505 Feiyanning Decoction can inhibit IL-6 and [IL-8] production *induced* by . Positive_regulation IL8 TNF 19697035 2258172 In contrast , the expression of [IL-8] in both cell types was strongly *stimulated* by both IL-1beta and . Positive_regulation IL8 TNF 19714766 2202730 Our study indicates that TLR9 signaling mediates , at least in part , the anti-inflammatory effects of natural commensal-origin DNA on the gut because TLR9 silencing abolished the inhibitory effect of natural commensal-origin DNA on *induced* [IL-8] secretion in polarized IECs . Positive_regulation IL8 TNF 19732956 2147096 Ectopic expression of NR4A2 leads to robust changes in endogenous IL-8 mRNA levels and co-treatment with *results* in significant ( p < 0.001 ) secretion of [IL-8] protein . Positive_regulation IL8 TNF 19732956 2147098 Transcriptional effects of NR4A2 on the human [IL-8] promoter are enhanced in the *presence* of , suggesting molecular crosstalk between TNF-alpha signalling and NR4A2 . Positive_regulation IL8 TNF 19734226 2139627 Here , we investigated the transcriptional mechanism involved in [CXCL8] *induction* by in cultured human airway smooth muscle ( HASM ) cells and compared these in cells from nonasthmatic and asthmatic individuals . Positive_regulation IL8 TNF 19734226 2139669 Furthermore , chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and RNA polymerase II to the [CXCL8] promoter of asthmatic HASM cells both in the *presence* and absence of stimulation . Positive_regulation IL8 TNF 19765578 2153527 *induced* mRNA induction of the chemokines , monocyte chemoattractant protein (MCP)-1 and [interleukin (IL)-8] , and the intercellular cell adhesion molecule ( ICAM)-1 , which are involved in adhesion between leukocytes and epithelial cells , was suppressed by M1-M4 , and M1 was the most efficacious . Positive_regulation IL8 TNF 19810018 2168618 Furthermore , naringin suppressed *mediated* release of [interleukin-6 and -8] ( IL-6 and IL-8 ) . Positive_regulation IL8 TNF 19874800 2196912 CSM and *induce* a dose- and time dependent increase in [IL-8] production . Positive_regulation IL8 TNF 19887769 2197285 Both and IL-1beta activated NF-kappaB and *stimulated* [IL-8] production . Positive_regulation IL8 TNF 19887769 2197291 The present data do not support the hypothesis that ibuprofen down-regulates [IL-8] production in *response* to and IL-1beta in CF respiratory epithelium . Positive_regulation IL8 TNF 19926933 2167180 Suppressive effect of an isoflavone fraction on *induced* [interleukin-8] production in human intestinal epithelial Caco-2 cells . Positive_regulation IL8 TNF 19926933 2167181 This study demonstrates the effect of soybean components on the *induced* production of [interleukin-8 (IL-8)] , one of the major inflammatory chemokines , in intestinal epithelial-like Caco-2 cells . Positive_regulation IL8 TNF 19926933 2167182 Among the soybean components , an isoflavone fraction ( IFF ) suppressed the *induced* [IL-8] secretion by Caco-2 cells in a dose dependent manner , whereas a soyasaponin fraction and soypeptide fraction had no significant effect on TNF-alpha induced IL-8 secretion . Positive_regulation IL8 TNF 19926933 2167183 The IL-8 secretion induced by hydrogen peroxide and by IL-1beta was not suppressed by IFF , suggesting that the inhibitory effect of isoflavone was specific for the *induced* regulation of [IL-8] . Positive_regulation IL8 TNF 19926933 2167186 These results indicate that IFF suppressed *induced* [IL-8] production at the transcriptional level in human intestinal Caco-2 cells , suggesting IFF of soybean as a promising food component for preventing intestinal inflammation such as inflammatory bowel disease . Positive_regulation IL8 TNF 19966295 2190824 Indole also decreased *mediated* activation of NF-kappaB , expression of the proinflammatory chemokine [IL-8] , and the attachment of pathogenic E. coli to HCT-8 cells , as well as increased expression of the antiinflammatory cytokine IL-10 . Positive_regulation IL8 TNF 19969371 2199623 Interestingly , *induced* [IL-8] secretion was enhanced by IL-17 in a dose dependent manner in HAM cells . Positive_regulation IL8 TNF 20042671 2200546 stimulated ChTRase release only from alveolar macrophages from smokers with COPD , and exposure of these cells to ChTRase *promoted* the release of [IL-8] , monocyte-chemoattractant protein-1 , and metalloproteinase-9 . Positive_regulation IL8 TNF 20053934 2225390 stimulation *induced* production of inflammatory cytokines such as IL-6 and [IL-8] in RSF , and the extent of IL-6 and IL-8 induction was dramatically reduced by CHPD under noncytotoxic concentrations . Positive_regulation IL8 TNF 20069129 2177871 In this study , we found that ticlopidine dose-dependently decreased the mRNA and protein levels of *stimulated* MCP-1 , [IL-8] , and vascular cell adhesion molecule-1 ( VCAM-1 ) in human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation IL8 TNF 20069129 2177877 These results suggest that ticlopidine decreased *induced* MCP-1 , [IL-8] , and VCAM-1 levels in HUVECs , and monocyte adhesion . Positive_regulation IL8 TNF 20138761 2213703 A structure activity relationship ( SAR ) investigation was conducted driven by the ability of these compounds to inhibit the p38alpha enzyme , the secretion of TNFalpha in a LPS challenged THP1 cell line and *induced* production of [IL-8] in the presence of 50 % human whole blood ( hWB ) . Positive_regulation IL8 TNF 20161853 2179373 Furthermore , *induced* secretion of IL-6 , [IL-8] , EGF , HGF , TGF-alpha , epiregulin , and amphiregulin were compared among these keratinocytes . Positive_regulation IL8 TNF 20161853 2179377 The significant induction of *increased* IL-6 , [IL-8] , EGF , HGF , TGF-alpha , epiregulin , and amphiregulin , but the increase in these cytokines and growth factors were not different among normal skin , uninvolved , and involved psoriasis . Positive_regulation IL8 TNF 20334899 2273151 In HCT 116 and HCT-8 colorectal adenocarcinoma cells , the production of [IL-8] immunoreactivity was *up-regulated* by IL-1beta , , the toll-like receptor (TLR) ligands double stranded RNA and peptidoglycan and phorbol ester . Positive_regulation IL8 TNF 20378831 2273550 The *induction* of the chemokine [interleukin-8] and the antiapoptotic protein cFLIP by were markedly less in HCT116 cells lacking DNMT than in parental cells . Positive_regulation IL8 TNF 20388003 2245288 Endotoxin , , and dust *stimulated* the release of IL-6 and [IL-8] in a time dependent manner . Positive_regulation IL8 TNF 20435921 2288107 TBP and TNF-SHARC dose-dependently inhibited *induced* secretion of interleukin (IL)-6 , [IL-8] , granulocyte macrophage-colony stimulating factor , and monocyte chemoattractant protein-1 in immortalized human endometriotic cells . Positive_regulation IL8 TNF 20463927 2257863 Expression of downstream TLR signalling pathways was demonstrated in hESC , and IL-1beta , and INFgamma , which bypass the TLRs , *stimulated* [CXCL8] release . Positive_regulation IL8 TNF 20478392 2307656 Conditioned medium from infected monocytes induced the secretion of [IL-8] and/or MCP-1 by A549 and Calu-6 cells , and these effects were mainly *mediated* by IL-1 ( in A549 cells ) or ( in Calu-6 cells ) . Positive_regulation IL8 TNF 20505949 2424458 The release of ENA-78 , [IL-8] and IL-6 by the isolated and monolayer cultured stromal cell fraction in the *presence* of IL-1ß ( 0.08 to 50 ng/mL ) , , and interferon-? ( both 20 to 500 ng/mL ) was determined . Positive_regulation IL8 TNF 20506163 2289317 In this study , we show that HK-2 cells express endothelial protein C receptor (EPCR) and that the occupancy of this receptor by protein C switches the signaling specificity of thrombin so that the activation of PAR-1 by thrombin inhibits the *mediated* synthesis of IL-6 and [IL-8] and down-regulates the TGF-beta mediated expression of ECM proteins . Positive_regulation IL8 TNF 20508179 2289417 In cultured human monocytes , Dll4 induces the transcription of Notch target gene Hes-1 and inhibits the basal and *stimulated* production of [interleukin-8] , the human functional homolog of murine CXCL1 . Positive_regulation IL8 TNF 20607584 2340396 Rebamipide inhibits *induced* [interleukin-8] expression by suppressing the NF-?B signal pathway in human umbilical vein endothelial cells . Positive_regulation IL8 TNF 20607584 2340397 This study was designed to identify the inhibitory effect of rebamipide on *induced* [interleukin-8 (IL-8)] production and nuclear factor-?B ( NF-?B ) activation in human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation IL8 TNF 20607584 2340398 *induced* [IL-8] expression was determined by enzyme linked immunosorbent assay ( ELISA ) and quantitative real-time polymerase chain reaction ( RT-PCR ) . Positive_regulation IL8 TNF 20607584 2340401 Rebamipide suppresses *induced* [IL-8] production through ( 1 ) inhibition of I?B-a phosphorylation in the cytoplasm and ( 2 ) blockage of NF-?B p65 protein transport into the nucleus . Positive_regulation IL8 TNF 20657842 2293428 *induced* a robust activation of MMP-9 , ICAM-1 , and the [IL-8] promoter driven reporter in Thy-1- MEFs , in contrast to only a modest increase in Thy-1+ counterparts . Positive_regulation IL8 TNF 20665032 2531492 Nicotine inhibits *induced* IL-6 and [IL-8] secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis . Positive_regulation IL8 TNF 20665032 2531494 Nicotine at concentrations of 0.1-10 µM dose reduced the protein and mRNA expression of IL-6 and [IL-8] *induced* by . Positive_regulation IL8 TNF 20673622 2305322 ( ii ) AREG gene silencing has a potent inhibitory effect on *induced* IL-6 and [IL-8] secretion in healthy SGEC treated with anti-Ro/SSA Abs . Positive_regulation IL8 TNF 20673622 2305324 These findings indicate that TACE mediated AREG shedding plays a critical role in *induced* IL-6 and [IL-8] secretion by the human healthy salivary gland epithelial cells , suggesting that this may be one of the possible intracellular mechanisms involved in the salivary glands inflammatory response in Sjögren 's syndrome . Positive_regulation IL8 TNF 20827577 2325247 *induces* vectorial secretion of [IL-8] in Caco-2 cells . Positive_regulation IL8 TNF 20827577 2325249 Basolateral stimulation with *resulted* in increased apical and basolateral [IL-8] production . Positive_regulation IL8 TNF 20827577 2325251 Apical stimulation *resulted* in increased apical , but not basolateral [IL-8] production . Positive_regulation IL8 TNF 20845069 2474770 The [IL-8] production ( secretion , mRNA expression , and transcriptional activity ) *induced* by both and H ( 2 ) O ( 2 ) was significantly higher than that by single stimulation . Positive_regulation IL8 TNF 20845069 2474771 Oxidative stress and may cooperatively *enhance* [IL-8] production via NF-?B in Caco-2 cells . Positive_regulation IL8 TNF 20857415 2375597 We therefore focused on the mechanism of OFSS regulation of TNF-receptor 1 (TNFR1) signaling and found that OFSS ( 1 ) reduced the amount of receptor on the cell surface , ( 2 ) prevented the association of ubiquitinated RIP in TNFR1 complexes with TRADD and TRAF2 , and ( 3 ) reduced *induced* [IL-8] promoter activity in the nucleus . Positive_regulation IL8 TNF 20943792 2347876 Quercetin , and to a lesser extent trans-RSV , attenuated the *induced* expression of inflammatory genes such as interleukin (IL)-6 , IL-1ß , [IL-8] , and monocyte chemoattractant protein-1 ( MCP-1 ) and the secretion of IL-6 , IL-8 , and MCP-1 . Positive_regulation IL8 TNF 2113076 135555 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL8 TNF 21172306 2378721 *induced* the expression of IL-6 , [IL-8] and sICAM in ECs . Positive_regulation IL8 TNF 21271591 2380807 [Interleukin-8] production in *response* to by cholesteatoma keratinocytes in cell culture . Positive_regulation IL8 TNF 21271591 2380809 Keratinocytes harvested from acquired cholesteatoma and grown in cell culture will demonstrate increased [interleukin-8 (IL-8)] production in *response* to as compared with a control keratinocyte cell line . Positive_regulation IL8 TNF 21271591 2380811 *stimulates* [IL-8] production in healthy epidermal keratinocyte cell lines . Positive_regulation IL8 TNF 21271591 2380812 It is not known whether *stimulates* [IL-8] production in cultured cholesteatoma keratinocytes . Positive_regulation IL8 TNF 21290470 2359943 Moreover , expression of E-selectin , IL-6 , and [IL-8] was *induced* most efficiently by IL-1ß , while LPS and had less effect , whereas we did not find such a difference in ICAM-1 and MCP-1 expression . Positive_regulation IL8 TNF 21300705 2414650 Corticosteroid sensitivity was evaluated by the inhibition of *induced* [interleukin 8 (IL-8)] production by budesonide . Positive_regulation IL8 TNF 21343177 2431547 Thymosin beta4 inhibits *induced* NF-kappaB activation , [IL-8] expression , and the sensitizing effects by its partners PINCH-1 and ILK . Positive_regulation IL8 TNF 21343177 2431550 We find that enforced expression of Tß ( 4 ) interferes with *mediated* NF-?B activation , as well as downstream [IL-8] gene transcription . Positive_regulation IL8 TNF 21349589 2399585 Stimulation of endothelial monolayers with *resulted* in significant increase of toll-like receptor 4 , [interleukin-6 and -8] , and intercellular adhesion molecule-1 and vascular cellular adhesion molecule-1 gene expression in a time dependent manner . Positive_regulation IL8 TNF 21468596 2413166 Stable transfection of this new isoform significantly decreased *induced* [IL-8] mRNA expression in HT-29 cells , but the expression of the IL-32a gene had no effect . Positive_regulation IL8 TNF 21468920 2413235 Polyozellin significantly inhibited *induced* [interleukin-8] secretion and mRNA expression . Positive_regulation IL8 TNF 21493783 2499816 In contrast to epithelial and endothelial cells , *stimulated* [CXCL8] synthesis was dependent on ERK1/ERK2 but not on p38 MAPK . Positive_regulation IL8 TNF 21576089 2430356 Depletion of RelA or ?Np63 by small interfering RNA ( siRNA ) significantly inhibited NF-?B-specific , or *induced* [IL-8] reporter activation . Positive_regulation IL8 TNF 21594484 407820 Stimulation of cells with both and IFN-gamma *increased* the biosynthesis of [IL-8] or endothelins significantly ( p < 0.05 ) . Positive_regulation IL8 TNF 21601196 2449978 synergistically *enhanced* IL-17F induced increase in [IL-8] secretion from ESCs . Positive_regulation IL8 TNF 21673103 2455410 Visfatin enhanced *induced* [CXC chemokine ligand (CXCL) 8] , CXCL10 , and CC chemokine ligand (CCL) 20 secretion and mRNA expression in keratinocytes , although visfatin alone was ineffective . Positive_regulation IL8 TNF 21673619 2538693 Prior macrophage exposure increased the secretion of [IL-8] and VEGF in *response* to stimulation whereas IL-6 production was increased in response to IL-1ß . Positive_regulation IL8 TNF 21719737 2471311 IL-18 did not enhance *induced* expression of intercellular adhesion molecule-1 or [IL-8] in LS174T . Positive_regulation IL8 TNF 21745554 2471933 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL8 TNF 2182081 131852 The *induction* of AMO derived [IL-8] by , lipopolysaccharide (LPS) , and interleukin-1 ( IL-1 beta ) was shown to be both dose and time dependent . Positive_regulation IL8 TNF 21827134 2472902 After searching for natural substances that regulate innate immunity using an ex vivo Drosophila culture system , we identified a novel dimeric chromanone , gonytolide A , as an innate immune promoter from the fungus Gonytrichum sp. along with gonytolides B and C. Gonytolide A also increased *stimulated* production of [IL-8] in human umbilical vein endothelial cells . Positive_regulation IL8 TNF 21828034 2539012 We investigated whether interleukin (IL)-17A induces GC insensitivity in airway epithelium by studying its effects on responsiveness of *induced* [IL-8] production to budesonide in human bronchial epithelial 16HBE cells . Positive_regulation IL8 TNF 21828034 2539013 We demonstrated that IL-17A induced IL-8 production is normally sensitive to GCs , while IL-17A pre-treatment significantly reduced the sensitivity of *induced* [IL-8] production to budesonide . Positive_regulation IL8 TNF 2185985 132002 and LPS , unlike the inflammatory monokine IL-6 , also *induced* [IL-8] expression . Positive_regulation IL8 TNF 21917909 2506792 Corticosteroid ( dexamethasone ) sensitivity was determined on *induced* [interleukin (IL)-8] production . Positive_regulation IL8 TNF 21917909 2506793 In vitro corticosteroid sensitivity on *induced* [IL-8] production was significantly lower in patients with severe asthma than in healthy volunteers and patients with mild asthma . Positive_regulation IL8 TNF 21969293 2502891 Caspase-5 knockdown reduced caspase-1 protein expression and activation and inhibited *induced* [IL-8] and MCP-1 . Positive_regulation IL8 TNF 21995333 2507619 Moreover induction of IL-6 and [IL-8] was primarily *regulated* by MC-derived . Positive_regulation IL8 TNF 21997704 2599359 Inhibition of *reduced* the spontaneous release of [CXCL-8] and CCL-3 . Positive_regulation IL8 TNF 22056837 2528068 More , our data showed no effect of azithromycin on IL-1ß- or *induced* [IL-8] secretion and NF-?B pathway activation . Positive_regulation IL8 TNF 22066831 2557333 Furthermore , intracellular ROS induced by tumor necrosis factor-a (TNF-a) were quantified , and expression of *induced* [interleukin-8] expression , which increases due to inflammatory reactions , was measured by ELISA and real-time RT-PCR . Positive_regulation IL8 TNF 22183741 2617280 In addition , treatment of endometriotic stromal cells with curcumin markedly inhibited *induced* secretion of IL-6 , [IL-8] and MCP-1 . Positive_regulation IL8 TNF 22207455 2585933 Vasoactive intestinal peptide enhances *induced* IL-6 and [IL-8] synthesis in human proximal renal tubular epithelial cells by NF-?B dependent mechanism . Positive_regulation IL8 TNF 22207455 2585939 We report here that *increased* IL-6 and [IL-8] production , and that these effects were potentiated by VIP at 10 nM in HK-2 cells . Positive_regulation IL8 TNF 22207455 2585943 These results strongly suggest that VIP synergistically enhances *stimulated* IL-6 and [IL-8] synthesis via activating the NF-?B pathway in HK-2 cells . Positive_regulation IL8 TNF 22268119 2580097 MK2 posttranscriptionally regulates *induced* expression of ICAM-1 and [IL-8] via tristetraprolin in human pulmonary microvascular endothelial cells . Positive_regulation IL8 TNF 22268119 2580103 A previous study by our group showed that MK2 regulates *induced* expression of intercellular adhesion molecule-1 ( ICAM-1 ) and [interleukin-8 (IL-8)] in human lung microvascular endothelial cells ; Positive_regulation IL8 TNF 22268119 2580109 In the present study , we performed experiments to determine whether MK2 regulates *induced* expression of ICAM-1 and [IL-8] via TTP in human pulmonary microvascular endothelial cells ( HPMECs ) . Positive_regulation IL8 TNF 22268119 2580115 These results , together with our previous study and others , suggest that MK2 , in HPMECs , regulates *induced* expression of ICAM-1 and [IL-8] via TTP at the mRNA decay level . Positive_regulation IL8 TNF 22427564 2588227 significantly *increased* the expression of IL-6 , [IL-8] , and MCP-1 in ARPE-19 cells at both the protein and mRNA levels . Positive_regulation IL8 TNF 22498762 2601797 Curcumin also inhibited the *induced* production of [IL-6/IL-8] in HaCaT cells . Positive_regulation IL8 TNF 2250017 146055 Among cytokines , only IL-1 and can *induce* [IL-8] gene expression at the transcriptional level . Positive_regulation IL8 TNF 2250017 146057 Transfection of a human fibrosarcoma cell line with chloramphenicol acetyltransferase expression plasmids linked to a 5'-flanking deletion mutants of the IL-8 gene demonstrated that the nucleotides between -94 and -71 base pairs from the start of the first exon are essential and sufficient for the [IL-8] *induction* by either IL-1 , , or phorbol 12-myristate 13-acetate . Positive_regulation IL8 TNF 22510965 2584225 We also demonstrated that pretreatment of cells with this compound prevented *induced* expression of NF-?B target genes , such as interleukin 6 , [interleukin 8] , monocyte chemotactic protein 1 , cyclooxygenase-2 and inducible nitric oxide . Positive_regulation IL8 TNF 22523282 2630952 In various cell types , transforming growth factor-ß activated kinase 1 ( TAK1 ) plays a crucial role in MAP kinase and NF-?B activation , as well as [IL-8] release *induced* by IL-1ß , , and lipopolysaccharide . Positive_regulation IL8 TNF 22525504 2522642 could *increase* the production of [IL-8] in MHCC-97H cells and p38 MAPK- NF-kB pathways seem to play a central role in the regulation of IL-8 production . Positive_regulation IL8 TNF 22526394 2595904 The human colon cell line , HT-29 , increased [interleukin (IL)-8] expression in *response* to recombinant human , but not in response to bacterial ligands and interferon (IFN)-gamma . Positive_regulation IL8 TNF 2254454 146314 This interaction appears to occur via the ability of human alveolar macrophage ( AM ) -derived monokines , , and interleukin-1 (IL-1) to *induce* gene expression of [IL-8] from pulmonary type II-like epithelial cells ( A549 ) . Positive_regulation IL8 TNF 22561123 2608701 Corilagin is a potent inhibitor of NF-kappaB activity and downregulates *induced* expression of [IL-8] gene in cystic fibrosis IB3-1 cells . Positive_regulation IL8 TNF 22616553 2632448 Stimulation with *increased* [IL-8] and eotaxin secretion , with increased IL-8 secretion by allergen exposed compared with naive control ASMC , post-TNF-a stimulation ( P = 0.001 ) . Positive_regulation IL8 TNF 22675954 2611443 Regulation of interleukin-1alpha and *induced* [interleukin-8] production by amnion derived ( WISH ) cells . Positive_regulation IL8 TNF 22675954 2611451 The production of [IL-8] was significantly *increased* by IL-1alpha or , and the increase of IL-8 stimulated by IL-1alpha was suppressed by IL-1 ra in a dose dependent manner . Positive_regulation IL8 TNF 22675954 2611453 The results of this study demonstrate that the production of [IL-8] *induced* by IL-1alpha and is enhanced by C2-ceramide , and suppressed by MEK inhibitor or P38 MAP kinase inhibitor . Positive_regulation IL8 TNF 22715179 2659493 In patients who developed TB-IRIS ( not on CTC ) IL-6 , [IL-8] , IL-12p40 , IL-18 , IP-10 , and *increased* during 2 weeks ( P = .04 ) of ART . Positive_regulation IL8 TNF 22754320 2623000 AP also effectively reduced *induced* mRNA expressions of monocyte chemoattractant protein (MCP)-1 and [interleukin (IL)-8] in a dose dependent manner . Positive_regulation IL8 TNF 22841897 2682360 Pretreatment with 1a,25- ( OH ) ( 2 ) D ( 3 ) significantly inhibited *induced* VCAM-1 expression and [IL-8] production in HCAECs . Positive_regulation IL8 TNF 22876745 2692263 miRNA-146a expression positively regulates *induced* [interleukin-8] production in mesenchymal stem cells and differentiated lung epithelial-like cells . Positive_regulation IL8 TNF 22876745 2692264 Overexpression of miRNA-146a , which positively regulates *induced* [IL-8] release , may enhance the inflammatory response in both BM-MSC and MSC-EC . Positive_regulation IL8 TNF 22895248 2647156 For example , activation of endothelial cells with cytokines like *results* in increased E-selectin and [IL-8] expression . Positive_regulation IL8 TNF 22911818 2657413 Corticosteroid sensitivity was determined by measuring dexamethasone inhibition of CD3/28 and *induced* [IL-8] production in PBMCs by using ELISA . Positive_regulation IL8 TNF 22926119 2657903 Pretreatment of HT-29 cells with LGG significantly blocked , and LPS *induced* [IL-8] activation at both mRNA and protein level ( p < 0.05 ) . Positive_regulation IL8 TNF 22988345 2674350 The EGF receptor and HER2 participate in *dependent* MAPK activation and [IL-8] secretion in intestinal epithelial cells . Positive_regulation IL8 TNF 22988345 2674378 As the epidermal growth factor receptor (EGFR) is a known transducer of proliferative signals and a potent activator of MAPKs , we hypothesized that the EGFR participates in *dependent* MAPK activation and [IL-8] secretion by intestinal epithelial cells ( IECs ) . Positive_regulation IL8 TNF 22988345 2674393 TNF-a treatment of IECs resulted in an association between EGFR and HER2 and inhibition of HER2 using a specific inhibitor AG879 in combination with AG1478 suppressed *dependent* ERK phosphorylation and [IL-8] release . Positive_regulation IL8 TNF 23009365 2843211 All NMs significantly *increased* [IL-8] production , with no change in levels of and IL-6 . Positive_regulation IL8 TNF 23132229 2696480 Exogenous H ( 2 ) S inhibited the *mediated* upregulation of NO , IL-6 and [IL-8] in a dose dependent manner . Positive_regulation IL8 TNF 23142559 2722762 *induced* [CXCL8] production by A549 cells : involvement of the non-neuronal cholinergic system . Positive_regulation IL8 TNF 23142559 2722764 In A549 cells , *increased* the release of [CXCL8] and ACh and the expression of the subtype 3 MR ( M3R ) . Positive_regulation IL8 TNF 23142559 2722765 Furthermore , *induced* [CXCL8] secretion was ( i ) inhibited by the MR antagonist tiotropium and the M3R antagonist 4-DAMP and ( ii ) enhanced by the M1/M3R agonist pilocarpine and the cholinesterase inhibitor physostigmine . Positive_regulation IL8 TNF 23142559 2722766 Taken as a whole , these results suggest that ACh release by A549 cells enhances *induced* [CXCL8] secretion through activation of the M3R . Positive_regulation IL8 TNF 23142559 2722794 Our results suggest that the *induced* secretion of [CXCL8] in A549 cells is regulated by the release of ACh , the latter 's binding to the M3R and the downstream activation of NF-?B and the ERK1/2 and p38 MAPK signaling pathways . Positive_regulation IL8 TNF 23147672 2729601 GnRH agonists or antagonists did not repress *induced* [IL-8] production in endometriotic stromal cells . Positive_regulation IL8 TNF 23211566 2752106 Unfractionated heparin significantly suppressed the *induced* and NF-?B mediated secretion and expression of [IL-8] and -6 as well as other molecules in decidualized and undifferentiated human ESCs . Positive_regulation IL8 TNF 23233723 2724505 Specific inhibition of miR-31 suppressed NF-?B-driven promoter luciferase activity and the basal and *induced* production of IL-1ß , CXCL1/growth related oncogene-a , CXCL5/epithelial derived neutrophil activating peptide 78 , and [CXCL8/IL-8] in human primary keratinocytes . Positive_regulation IL8 TNF 23263807 2709307 Inhibitory effect on *induced* [IL-8] secretion in HT-29 cell line by glyceroglycolipids from the leaves of Ficus microcarpa . Positive_regulation IL8 TNF 23263807 2709308 The antiinflammatory effect of these compounds on *induced* [IL-8] secretion in the HT-29 cell line was evaluated . Positive_regulation IL8 TNF 23278752 2752359 Moreover , TLR agonists differentially regulated *induced* [IL-8] and CXCL10 production by the tested cell types . Positive_regulation IL8 TNF 23281820 2775380 Rapamycin enhances *induced* secretion of IL-6 and [IL-8] through suppressing PDCD4 degradation in orbital fibroblasts . Positive_regulation IL8 TNF 23281820 2775382 To investigate the effects of rapamycin on the *induced* secretion of interleukin-6 (IL-6) and [IL-8] in orbital fibroblasts and its possible mechanism . Positive_regulation IL8 TNF 23281820 2775384 Rapamycin significantly enhanced *induced* IL-6 and [IL-8] secretion from orbital fibroblasts . Positive_regulation IL8 TNF 23281820 2775387 Down-regulation of PDCD4 by PDCD4 siRNA transfection reduced *induced* IL-6 and [IL-8] secretion from orbital fibroblasts . Positive_regulation IL8 TNF 23281820 2775391 Rapamycin enhances the *induced* secretion of IL-6 and [IL-8] by suppressing PDCD4 degradation in orbital fibroblasts . Positive_regulation IL8 TNF 23286514 2793658 Neither hydrolysate suppressed [IL-8] production *induced* by or IL-1ß , suggesting an effect on the Toll-like receptor (TLR) 4 pathway , the cellular sensor for LPS . Positive_regulation IL8 TNF 23295714 2752461 Sevoflurane suppressed *induced* IL-6 , [IL-8] , and MCP-1 gene expression and the production of IL-6 and IL-8 in SAEC under anoxia/reoxygenation conditions . Positive_regulation IL8 TNF 23364439 2754517 Hyperosmolarity alone had no effect on either basal IL-8 release or ICAM-1 surface expression but did lead to concentration dependent decreases in *induced* [IL-8] release , ICAM-1 surface expression , and PMN-HMVEC adhesion . Positive_regulation IL8 TNF 23364439 2754532 Despite this basal activation , hyperosmolar incubation attenuated *stimulated* [IL-8] release and ICAM-1 surface expression and subsequent PMN adherence , while p38 MAPK inhibition did not further influence the effects of hyperosmolar conditions on ICAM-1 surface expression . Positive_regulation IL8 TNF 23365744 2712926 stimulation *caused* similar IL-1ß , IL-6 , and [IL-8] release in all groups . Positive_regulation IL8 TNF 23390497 2739715 Three lipopeptides *induced* high levels of [IL-8] production , above that of equivalent concentrations of cathelicidin LL-37 , while no compound induced production of the pro-inflammatory cytokine at or below 100 µM . Positive_regulation IL8 TNF 23621293 2804778 induced NF?B activation in rat and human conjunctival fibroblasts and epithelial cells , and *caused* production and release of cytokines [IL-8] and RANTES . Positive_regulation IL8 TNF 23675779 2833791 Type I and type II interferons inhibit both basal and *induced* [CXCL8] secretion in primary cultures of human thyrocytes . Positive_regulation IL8 TNF 23675779 2833792 This study demonstrates that type I and type II IFNs downregulate both basal and *induced* [CXCL8] secretion by human thyrocytes , IFN-? being the most powerful inhibitor . Positive_regulation IL8 TNF 2370931 138358 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL8 TNF 23800251 2808003 Finally , CCL20 and [CXCL8] responded synergistically in *response* to EGF and in OVCAR-3 and SKOV-3 cells . Positive_regulation IL8 TNF 23845509 2829379 Moreover , GTN down-regulated translocation of the p50/p65 heterodimer to the nucleus , prevented binding of NF-?B to its DNA response element and reduced *activated* [interleukin-8 (IL-8)] expression . Positive_regulation IL8 TNF 23940786 2827126 ETs inhibited [IL-8] secretion *induced* by and IL-1ß at low concentrations ( IC50 range of 0.7-4 µg/mL ) . Positive_regulation IL8 TNF 23967134 2832634 E3330 treatment prevented the functional activation of NF-?B via the alteration of APE1 subcellular trafficking and reduced IL-6 and [IL-8] expression *induced* by and FAs accumulation through blockage of the redox mediated activation of NF-?B . Positive_regulation IL8 TNF 24030221 2902156 Furthermore , passive smoke exposure reduced the inhibitory effects of dexamethasone on *induced* [CXCL8] release in AMs . Positive_regulation IL8 TNF 24129565 2875072 Chromatin immunoprecipitation ( ChIP ) assays demonstrated decreased NF-?B binding to the promoters of IL-6 , [IL-8] , and I?Ba in *response* to with TGF-ß1 pretreatment . Positive_regulation IL8 TNF 24226202 2921148 Hierarchical analysis of genes using RNA interference showed that both and IL-1ß *regulate* the expression of [IL-8] through independent pathways in response to reduced hydration . Positive_regulation IL8 TNF 24349530 2881288 Inhibitors of cPLA2a enzyme activity ( AVX002 , ATK ) significantly reduced *induced* cellular release of AA , PGE2 , [IL8] and MMP3 . Positive_regulation IL8 TNF 24534785 2942605 AKF-PD significantly inhibited *induced* expression of interleukin-6 , monocyte chemoattractant protein-1 and [interleukin-8] and nuclear translocation of p65 in HK-2 cells . Positive_regulation IL8 TNF 24659790 2949104 HCV protein expression in Huh7 hepatocytes also induced SOCS3 and directly inhibited *mediated* [IL-8] production . Positive_regulation IL8 TNF 24905701 2952083 Furthermore , HMGB1 and IL-1ß and/or a ( but not HMGI/Y ) also significantly *induced* inducible nitric oxide synthase , NO , and [interleukin (IL)-8] production in human cartilage and chondrocytes . Positive_regulation IL8 TNF 3011946 59767 Tumor necrosis interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL8 TNF 3486658 59966 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL8 TNF 3486658 60020 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL8 TNF 3486936 60109 ( cachectin ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL8 TNF 3500495 80718 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL8 TNF 3526909 62659 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL8 TNF 7500047 336176 Both and GM-CSF *stimulated* [IL-8] production ; Positive_regulation IL8 TNF 7500047 336180 [IL-8] production *induced* by and GM-CSF was synergistically enhanced in the presence of MSU or CPPD , whereas MIP-1 alpha secretion induced by TNF was completely inhibited in the presence of either MSU or CPPD . Positive_regulation IL8 TNF 7506142 237755 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL8 TNF 7519403 265590 Dexamethasone blocks the *induction* of IL-6 and [IL-8] by IL-1 or . Positive_regulation IL8 TNF 7519403 265595 Both IL-1 and *increased* release of IL-6 and [IL-8] from the cells in a dose dependent manner and dexamethasone inhibited this effect . Positive_regulation IL8 TNF 7543732 314372 Apigenin also inhibited IL-1 alpha induced prostaglandin synthesis and *induced* IL-6 and [IL-8] production , suggesting that the hydroxyflavones may act as general inhibitors of cytokine induced gene expression . Positive_regulation IL8 TNF 7545393 318530 We show that pyrrolidine dithiocarbamate strongly reduces the mediated *induction* of E-selectin , VCAM-1 , ICAM-1 , PAI-1 , tissue factor , [IL-8] and I kappa B-alpha . Positive_regulation IL8 TNF 7575485 325130 Calyculin A also acted synergistically with IL-1 or TNF alpha to cause a 2-fold potentiation of IL-1- or *induced* [IL-8] mRNA and peptide and RANTES mRNA expression . Positive_regulation IL8 TNF 7575568 325143 The nitric oxide synthase inhibitor , NG-amino-L-homoarginine ( NAHA ) , inhibited *stimulated* [IL-8] promoter activity by 60 % . Positive_regulation IL8 TNF 7594569 325864 This study shows that the pathways leading to cell death and [IL-8] production in *response* to Fas Ag ligation and were similar with regard to their requirements for new gene expression , protein synthesis , and protein kinase activity . Positive_regulation IL8 TNF 7600258 311520 However , PMA and *induced* [IL-8] production that coincided with significant cell cycle inhibition . Positive_regulation IL8 TNF 7600258 311523 At all concentrations tested , reduced the mitotic index by approximately 45 % , slowed cell cycle progression by approximately 3.5 h , and *induced* a flat , albeit large , [IL-8] response at concentrations > or = 12.5 ng/ml . Positive_regulation IL8 TNF 7694480 234310 In particular , we assessed whether dexamethasone was capable of inhibiting the *mediated* secretion of interleukin-6 (IL-6) , [interleukin-8 (IL-8)] , and granulocyte colony stimulating factor ( G-CSF ) by a human bronchial epithelial cell line ( BEAS-2B ) . Positive_regulation IL8 TNF 7737374 305527 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL8 TNF 7794282 313540 The NO synthase inhibitor , ( L ) -NG-nitroarginine methyl ester ( L-NAME ) , inhibited the *stimulated* [IL-8] production in the human endothelial cell line , ECV304 , in a dose dependent manner without affecting cellular viability ( TNF alone , 5.5 +/- 0.9 ng/ml ; TNF + 5 mM L-NAME , 2.4 +/- 0.5 ng/ml ) . Positive_regulation IL8 TNF 7810274 284968 The potent neutrophil activator and chemotaxin [interleukin-8 (IL-8)] is released in *response* to and recent interest has focussed on its possible role in producing the characteristic peripheral blood neutrophilia and liver neutrophil infiltrate in alcoholic hepatitis . Positive_regulation IL8 TNF 7875467 298280 and IL-1 beta dose-dependently *induced* [IL-8] production in HT-29 cells . Positive_regulation IL8 TNF 7875467 298282 However , *induction* of [IL-8] by IL-1 beta or was reduced by the PTK inhibitors herbimycin ( by 79 % or 89 % , respectively ) and genistein ( by > 95 % ) . Positive_regulation IL8 TNF 7875467 298287 The synthesis of [IL-8] is *stimulated* in HT-29 cells by IL-1 beta or . Positive_regulation IL8 TNF 7880974 289091 *stimulated* synovial fibroblast DNA synthesis and the release of IL-6 , [IL-8] and PGE2 was inhibited by antagonist monoclonal antibodies against either the p55 or the p75 TNF receptor , although the blockade of the p55 TNF receptor had a more potent effect than inhibition of the p75 TNF receptor alone . Positive_regulation IL8 TNF 7880974 289094 Both p55 and p75 TNF receptors on dermal and gingival fibroblasts were also involved in *mediated* DNA synthesis and IL-6 , [IL-8] and PGE2 release , although differences in the levels of DNA synthesis and release of inflammatory cytokines and PGE2 were observed between the three fibroblast types . Positive_regulation IL8 TNF 7922784 272998 Dexamethasone regulates IL-1 beta and *induced* [interleukin-8] production in human bone marrow stromal and osteoblast-like cells . Positive_regulation IL8 TNF 7934096 275456 A local production of these cytokines can not be excluded , because interleukin-6 and [interleukin-8] are produced by stimulated macrophages and monocytes in *response* to and interleukin-1 beta . Positive_regulation IL8 TNF 7943343 276425 *induced* [interleukin-8] expression in cultured human airway epithelial cells . Positive_regulation IL8 TNF 7943343 276427 There was no change in the stability of IL-8 mRNA , and a nuclear run-on assay confirmed that *increased* [IL-8] gene transcription . Positive_regulation IL8 TNF 7981153 281389 Unexpectedly , IL-1 alpha and efficiently *induced* [IL-8] production and IL-8 mRNA in NPD type A fibroblasts as in normal fibroblasts . Positive_regulation IL8 TNF 8035808 265130 Earlier we demonstrated that beta interferon ( IFN-beta ) can inhibit *induced* [IL-8] gene expression at the transcriptional level , apparently by a novel mechanism . Positive_regulation IL8 TNF 8052491 267766 and IL-1 beta significantly *augmented* the levels of mRNA expression for [IL-8] and its production . Positive_regulation IL8 TNF 8069926 270001 Addition of anti-TNF and anti-IL-1 beta antibodies to IFN-gamma plus LPS treated PMN indicated that the LPS induced production of endogenous and IL-1 beta , which was further potentiated by IFN-gamma pretreatment , *mediated* in autocrine fashion the enhanced LPS induced [IL-8] accumulation observed at 18 hr . Positive_regulation IL8 TNF 8117936 241884 When various immunosuppressive drugs were tested , glucocorticoids but not other immunosuppressive drugs markedly inhibited the IL-1 or *induced* [IL-8] and MCAF mRNA accumulation , suggesting that glucocorticoid is a potent regulator of these inflammatory cytokine production in the neural tissues . Positive_regulation IL8 TNF 8132326 251533 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL8 TNF 8166294 254872 This facilitation is dependent on *stimulated* production of [IL-8] . Positive_regulation IL8 TNF 8188354 256764 IL-1 alpha and *induced* significantly higher levels of [IL-8] secretion than did E. coli Hu734 . Positive_regulation IL8 TNF 8216423 231662 and IL-1 beta *induced* a time- and dose dependent release of immunoreactive [IL-8] . Positive_regulation IL8 TNF 8244994 236722 In the human hepatoma cell line Hep-G2 , Me2SO dose-dependently inhibited *stimulated* [IL-8] production , with a 74 +/- 1 % reduction observed at a Me2SO concentration of 1 % . Positive_regulation IL8 TNF 8410139 233491 The [IL-8] secretion *increased* with the stimulation by . Positive_regulation IL8 TNF 8421182 210669 Endotoxin and *induced* [interleukin-8] release in humans . Positive_regulation IL8 TNF 8421182 210670 These data indicate that IL-8 is released in humans after injection of endotoxin and TNF alpha and suggest that endotoxin induced [IL-8] release is *mediated* by . Positive_regulation IL8 TNF 8501341 220941 The *role* of in [interleukin (IL)-8] release in septicemia in the baboon ( 2-h infusion of live Escherichia coli , 5 x 10 ( 8 ) cfu/kg ) was investigated . Positive_regulation IL8 TNF 8506955 221476 Stimulation of HPMC with IL-1 beta or *resulted* in a time- and dose dependent [IL-8] generation ; Positive_regulation IL8 TNF 8534611 331219 NHEK cells spontaneously secrete [IL-8] ( 243.4 +/- 55.5 pg/ml ) , and this baseline level was *augmented* by TNF-alpha alone , or synergistically by and IFN-gamma , which are thought to be secreted by T cells . Positive_regulation IL8 TNF 8572249 340728 We hypothesized that RSV directly *induces* [interleukin (IL)-8] gene expression in airway epithelial cells , independent of IL-1 beta and production . Positive_regulation IL8 TNF 8592105 341923 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL8 TNF 8592105 341978 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL8 TNF 8624246 360189 In the same cultures , induced marked *increases* in release of both [IL-8] and IL-6 at 24 and 48 h after stimulation . Positive_regulation IL8 TNF 8647994 343036 On the other hand , it enhanced IL-1 alpha- and *induced* [IL-8] secretion in NHKs . Positive_regulation IL8 TNF 8673632 343150 alone *induces* the endothelial release of [Interleukin-8 (Il-8)] as well as the expression of P- and E-selectin . Positive_regulation IL8 TNF 8683138 370277 TGF-beta 1 treatment did not significantly alter the *induced* [IL-8] mRNA stability , suggesting that the mechanism of action of TGF-beta 1 is on gene transcription . Positive_regulation IL8 TNF 8820249 344541 Spontaneous and *induced* GM-CSF or [IL-8] released levels increased significantly with time . Positive_regulation IL8 TNF 8820249 344543 *potentiated* GM-CSF and IL-8 release in control subjects and only the [IL-8] production in asthmatics . Positive_regulation IL8 TNF 8820249 344545 Nedocromil sodium , at the concentration of 10 ( -6 ) M , reduced the *induced* increase in GM-CSF but not the [IL-8] release . Positive_regulation IL8 TNF 8832978 385874 Antioxidants inhibit *mediated* stimulation of [interleukin-8] , monocyte chemoattractant protein-1 , and collagenase expression in cultured human synovial cells . Positive_regulation IL8 TNF 8832978 385876 *increased* the expression of [IL-8] , MCP-1 , and collagenase mRNA in human synovial cells . Positive_regulation IL8 TNF 8832978 385882 Our data suggest that *induces* expression of proinflammatory cytokines such as [IL-8] and MCP-1 through generation of reactive oxygen intermediates and subsequent activation of NF-kappa B in human synovial cells , and the antioxidants may inhibit , at least in part , the activation of NF-kappa B by TNF-alpha . Positive_regulation IL8 TNF 8873050 389814 A pronounced increase of [IL-8] mRNA expression and protein production was *induced* by . Positive_regulation IL8 TNF 8873050 389816 Interferon-gamma (IFN gamma) partially inhibited *induced* [IL-8] secretion , whereas no influence on IL-8 mRNA levels was detected . Positive_regulation IL8 TNF 8886420 391173 5 . IL-13 was found to up-regulate significantly ( P < 0.01 ) the IL-1 alpha but not the *induced* [IL-8] generation by HT-29 cells . Positive_regulation IL8 TNF 8886420 391175 In contrast , IL-10 had no effect on either IL-1 alpha or *induced* [IL-8] production . Positive_regulation IL8 TNF 8886420 391181 7. These findings suggest that colonic epithelial cells have a functional IL-13 receptor , which is coupled to an up-regulation of IL-1 alpha , but not *induced* [IL-8] generation . Positive_regulation IL8 TNF 8895217 392426 IL-beta and highly *stimulated* IL-6 , LIF and [IL-8] productions . Positive_regulation IL8 TNF 8900181 393437 Synergistic *activation* of [interleukin-8] gene transcription by all-trans-retinoic acid and involves the transcription factor NF-kappaB . Positive_regulation IL8 TNF 8900181 393444 *Induction* of [interleukin-8 (IL-8)] by IL-1 or , and repression by interferons or glucocorticoids have been shown to involve sequences between nucleotides -94 and -71 of the 5'-flanking region , and the transcription factors NF-IL-6 and NF-kappaB . Positive_regulation IL8 TNF 8910536 395220 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation IL8 TNF 8943702 400119 In this study , we examined the ability of interleukin-7 to induce RPE derived monocyte chemotactic protein-1 and interleukin-8 and assessed the potentiating effects of interleukin-7 on interleukin-1 beta- and *induced* RPE monocyte chemotactic protein-1 and [interleukin-8] production . Positive_regulation IL8 TNF 8943702 400131 Interleukin-7 potentiated tumor necrosis factor-alpha induced RPE monocyte chemotactic protein-1 steady-state mRNA expression at all doses of interleukin-7 while only high dose interleukin-7 ( 100 ng ml-1 ) enhanced *induced* RPE [interleukin-8] steady-state gene expression . Positive_regulation IL8 TNF 8943702 400136 These studies suggest that interleukin-7 potentiation of interleukin-1 beta and *induced* RPE monocyte chemotactic protein-1 and [IL-8] may be important for the elicitation of leukocyte chemotaxins in diseased retinal tissue when only low ambient levels of individual pro-inflammatory cytokines are present . Positive_regulation IL8 TNF 8977311 403227 Inhibitors of *diminished* ( < or = 45 % ) , but did not abolish the expression of cell adhesion molecules and IL-6 induced by S-PM , [IL-8] production being insignificantly affected ( < or = 10 % ) . Positive_regulation IL8 TNF 9018013 412174 We investigated the production of [interleukin-8 (IL-8)] and chemotactic activity released from Chang liver cells subjected to long-term treatment with ethanol ( Et ) and subsequent *stimulation* with . Positive_regulation IL8 TNF 9040477 415869 In contrast , CSA significantly inhibited *stimulated* , but not IL-1 beta stimulated , HRPE MCP-1 and [IL-8] secretion . Positive_regulation IL8 TNF 9040477 415871 IL-1 beta induced chemokine secretion is sensitive to DEX , whereas MCP-1 and [IL-8] *induced* by are inhibited by CSA . Positive_regulation IL8 TNF 9040478 415877 IFN-gamma induced dose dependent increases in HRPE MCP-1 , but not IL-8 , IFN-gamma potentiated IL-1 beta and TNF-alpha induced MCP-1 production , but showed little modulation of IL-1 beta and *induced* [IL-8] production . Positive_regulation IL8 TNF 9077472 420392 Upon *stimulation* with interleukin-1beta (IL-1beta) and , both HDMECs and HMEC-1 expressed high levels of [IL-8] , GRO , and monocyte chemoattractant protein-1 ( MCP-1 ) . Positive_regulation IL8 TNF 9164965 432162 Although IL-1 and also *induce* [IL-8] and E-selectin , the thrombin effects in these experiments were not mediated by those cytokines , since neither IL-1 receptor antagonist nor anti-TNF-alpha Ab inhibited the effects of thrombin . Positive_regulation IL8 TNF 9199336 438915 Administration of a NF-kappaB antisense oligonucleotide almost completely inhibited *dependent* [IL-8] production and partially abrogated TNF-alpha dependent VEGF production , and an Sp1 antisense sequence partially inhibited TNF-alpha dependent production of VEGF . Positive_regulation IL8 TNF 9209275 441020 TBP I completely abolished TNF induced IL-6 production and E-selectin induction , while it partially inhibited *induced* [IL-8] production and up-regulation of ICAM-1 and VCAM-1 . Positive_regulation IL8 TNF 9223588 442887 Investigation into the mechanism of action of hymenialdisine showed that it was not due to inhibition of protein kinase C because the selective protein kinase C inhibitor RO 32-0432 was inactive against *stimulated* luciferase and [IL-8] production . Positive_regulation IL8 TNF 9237814 445739 *Stimulation* of [IL-8] production in human gastric epithelial cells by Helicobacter pylori , IL-1beta and requires tyrosine kinase activity , but not protein kinase C . Positive_regulation IL8 TNF 9292787 452839 Quercetin , a bioflavonoid , inhibits the *induction* of [interleukin 8] and monocyte chemoattractant protein-1 expression by in cultured human synovial cells . Positive_regulation IL8 TNF 9292787 452841 Quercetin suppresses *mediated* stimulation of [IL-8] and MCP-1 expression , at least in part , by inhibiting the activation of NF-kappa B . Positive_regulation IL8 TNF 9316507 456180 In contrast , TGF-beta had a modest inconsistent stimulatory effect on IL-8 release by itself and had no effect on the [IL-8] release *induced* by . Positive_regulation IL8 TNF 9349985 460806 CsA ( 1 , 5 , and 10ng/ml ) significantly reduced IL-1 beta induced IL-8 production ( by 32 % , 41 % , and 48 % , respectively ) , and reduced *induced* [IL-8] production ( by 21 % , 42 % , and 50 % , respectively ) . Positive_regulation IL8 TNF 9349985 460808 FK506 or DEX had no effect on IL-1 beta- or *induced* [IL-8] production . Positive_regulation IL8 TNF 9375973 465371 IL-13 , but not IL-10 , significantly enhanced [IL-8] and MCP-1 release in *response* to IL-1alpha or . Positive_regulation IL8 TNF 9393813 467927 In addition , dexamethasone was found to stimulate IL-6 and [IL-8] secretion ( in the presence or absence of LPS ) but did not *induce* any secretion of . Positive_regulation IL8 TNF 9407069 470799 Northern blot analysis revealed that *induced* both ICAM-1 and [IL-8] expression in either the A549 lung epithelial cell line or the human microvessel endothelial cell line ( HMEC-1 ) . Positive_regulation IL8 TNF 9407069 470801 *induced* greater [IL-8] gene expression as compared with H2O2 , but the kinetics of induction were similar . Positive_regulation IL8 TNF 9427069 472692 Administration of or IL-1 beta *induced* [IL-8] production ; Positive_regulation IL8 TNF 9441701 475945 Substantial dose- and time dependent RPE secretion of [IL-8] was *observed* following stimulation with IL-1 beta or , but cell associated IL-8 was detectable only after high dose ( 20 ng ml-1 ) IL-1 beta stimulation and comprised less than 1 % of the total IL-8 induced . Positive_regulation IL8 TNF 9448049 483781 *stimulated* [IL-8] mRNA expression and protein release in a time- and dose dependent manner , whereas IFN-gamma alone had no effect . Positive_regulation IL8 TNF 9448049 483782 [IL-8] release *induced* by and IFN-gamma was partly inhibited by the Th-2 derived cytokines IL-4 , IL-10 , and IL-13 , as well as by dexamethasone . Positive_regulation IL8 TNF 9452482 484154 A promoter recruitment mechanism for *induced* [interleukin-8] transcription in type II pulmonary epithelial cells . Positive_regulation IL8 TNF 9520946 493676 Collectively , these results suggest specific potentiation of *induced* HRPE [IL-8] by human serum albumin that has been glycated either during circulation or locally within tissue . Positive_regulation IL8 TNF 9547339 499277 When lipoxins and LXA4 stable analogs were evaluated for enterocyte functional as well as immune responses , lipoxins sharply inhibited *induced* [IL-8] release but did not alter either barrier function or agonist stimulated chloride secretion . Positive_regulation IL8 TNF 9551998 499168 *Induction* of inducible nitric-oxide synthase (iNOS) , IL-1beta , and [IL-8] genes by IL-1beta , , or PMA was blocked in Ad5 IkappaB infected cells but not in Ad5 LacZ controls as assayed by RT-PCR and ELISA . Positive_regulation IL8 TNF 9552003 499173 In contrast , while [IL-8] production in response to S. cerevisiae and zymosan was enhanced in the *presence* of , no MIP-1alpha was produced . Positive_regulation IL8 TNF 9581802 503504 These results indicate important roles of IL-8 in LPS induced delayed VP and that *causes* the delayed VP through the production of [IL-8] . Positive_regulation IL8 TNF 9594359 505925 Activation by *induced* [interleukin-8] production by B lymphocytes . Positive_regulation IL8 TNF 9657919 516887 IL-1beta and synergistically *induced* IL-6 and GM-CSF and additively induced [IL-8] and MCP-1 production , while IL-2 , IL-10 , IFN-alpha , and IFN-gamma had little or no additional effects . Positive_regulation IL8 TNF 9660302 517296 Inactivation of the NF-kappaB and 3'NF-IL-6 DNA binding sites decreased IL-8 gene transcriptional activation in response to TNF while inactivation of the 5'NF-IL-6 binding site increased [IL-8] gene transcriptional activity in *response* to . Positive_regulation IL8 TNF 9660302 517298 This system may be useful to assess the effects of ethanol on *induced* hepatocyte [IL-8] production . Positive_regulation IL8 TNF 9698592 524955 Again , *stimulated* [IL-8] production did not differ significantly between cell lines with and without functioning CFTR . Positive_regulation IL8 TNF 9698598 524957 Inhibition of *induced* NF-kappaB activation and [IL-8] release in A549 cells with the proteasome inhibitor MG-132 . Positive_regulation IL8 TNF 9698598 524960 The working hypothesis of the studies described herein was that inhibition of proteasome mediated IkappaB degradation would inhibit *induced* nuclear factor-kappaB (NF-kappaB) activation , interleukin-8 (IL-8) gene transcription , and [IL-8] protein release in A549 cells . Positive_regulation IL8 TNF 9698598 524963 Mutational analysis of the 5 ' flanking region of the IL-8 gene confirmed that an intact NF-kappaB site is necessary for *induced* [IL-8] gene transcription . Positive_regulation IL8 TNF 9698598 524965 These studies show that inhibition of proteasome mediated IkappaB degradation results in inhibition of *induced* [IL-8] production in A549 cells by limiting NF-kappaB mediated gene transcription . Positive_regulation IL8 TNF 9712752 527385 Our findings support a *role* for P. haemolytica LPS and in the induction of [IL-8] from bovine alveolar macrophages . Positive_regulation IL8 TNF 9726445 529769 Using human Hep G2 cells , it was demonstrated that , in contrast to lipopolysaccharides (LPS) , both ( TNF-beta ) and H2O2 are potent *inducers* of [IL-8] , presumably acting via protein kinase C ( PKC ) -dependent pathways . Positive_regulation IL8 TNF 9726445 529770 Furthermore , in vitro TNF-alpha neutralization experiments and transfection of Hep G2 cells with an IL-8 construct confirmed that and H2O2 directly *stimulate* [IL-8] secretion . Positive_regulation IL8 TNF 9738669 531834 In contrast , TNF-alpha and LPS both induced [IL-8] mRNA , and *induction* by either or LPS was blocked by SB202190 . Positive_regulation IL8 TNF 9740146 531992 Interleukin-1beta , ( 100 pmol/L ) , ( 1 nmol/L ) , and lipopolysaccharide ( 1 microg/mL ) each *increased* the release of IL-6 , [IL-8] , and monocyte chemoattractant protein-1 by MaMi cells . Positive_regulation IL8 TNF 9820542 547565 Staphylococcal enterotoxin A-induced injury of human lung endothelial cells and [IL-8] accumulation are *mediated* by . Positive_regulation IL8 TNF 9830008 551249 H2O2 and *induce* differential binding of the redox-responsive transcription factors AP-1 and NF-kappaB to the [interleukin-8] promoter in endothelial and epithelial cells . Positive_regulation IL8 TNF 9830008 551258 We previously demonstrated that and H2O2 differentially *regulate* [interleukin-8 (IL-8)] and intercellular adhesion molecule ( ICAM-1 ) gene expression in endothelial and epithelial cells . Positive_regulation IL8 TNF 9830008 551268 Unlike H2O2 , the proinflammatory cytokine *induced* [IL-8] and ICAM-1 in both cell types . Positive_regulation IL8 TNF 9830008 551290 These data indicate that the cell type-specific *induction* of [IL-8] gene expression by H2O2 and in HMEC-1 and A549 cells can be explained by the differential binding of AP-1 and NF-kappaB to the IL-8 promoter . Positive_regulation IL8 TNF 9893037 558645 IL-1beta and *induced* the synthesis of [IL-8] at 24 hr , but partially inhibited the synthesis at 48 hr . Positive_regulation IL8 TNF 9918428 559144 These findings suggest that bile acids inhibit *induced* [IL-8] production by the colonic cells . Positive_regulation IL8 TNF 9950270 589756 Upon *stimulation* with or LPS , HUVEC produced [IL-8] and PTX affected this process in opposing fashions , with inhibition of the effects of TNF and augmentation of those of LPS . Positive_regulation IL8 TNFSF10 11784850 901104 We demonstrate that DR5 ligation by either or TRA-8 *induces* two functional outcomes , apoptosis and expression of the chemokine [interleukin-8 (IL-8)] ; Positive_regulation IL8 TNFSF10 11784850 901106 the caspase 3-specific inhibitor z-DEVD-Fmk suppresses *mediated* apoptosis but not [IL-8] induction ; Positive_regulation IL8 TNFSF10 12874246 1115005 In surviving cells , activates NF-kappaB , *induces* expression of E-selectin , ICAM-1 , and [IL-8] , and promotes adhesion of leukocytes . Positive_regulation IL8 TNFSF10 16227629 1483596 *induced* secretion of [interleukin-8] and monocyte chemoattractant protein-1 , augmenting macrophage migration . Positive_regulation IL8 TNFSF10 16751802 1645925 Here , we show that strongly *induces* the expression of the proinflammatory cytokines [interleukin-8] and monocyte chemoattractant protein 1 and enhances the invasion of apoptosis-resistant pancreatic ductal adenocarcinoma cells in vitro by upregulation of the urokinase-type plasminogen activator expression . Positive_regulation IL8 TNFSF10 18313665 1886032 *stimulated* production of several cytokines , [IL-8] , RANTES , MCP-1 and bFGF , and activation of caspases 1 and 8 was essential for this effect . Positive_regulation IL8 TNFSF10 18790747 1963700 We conclude that endogenous and *induced* [IL-8] signaling can modulate the extrinsic apoptosis pathway in prostate cancer cells through direct transcriptional regulation of c-FLIP . Positive_regulation IL8 TNFSF10 19349211 2088725 Functionally , did not induce apoptosis but rather enhanced the proliferation of PTEC through activation of PI3 kinase/AKT and ERK1/2 , *increased* [IL-8] production and upregulated ICAM-1 expression . Positive_regulation IL8 TNFSF10 23392805 2739919 *induced* expression of uPA and [IL-8] strongly enhanced by overexpression of TRAF2 and Bcl-xL in pancreatic ductal adenocarcinoma cells . Positive_regulation IL8 TNFSF10 23392805 2739921 The purpose of this study was to investigate the roles of the pro-apoptotic TRAIL receptors , TRAIL-R1 and TRAIL-R2 , as well as Bcl-xL and TRAF2 in *induced* expression of the pro-inflammatory cytokine [IL-8] and the invasion promoting protein urokinase ( uPA ) in pancreatic ductal adenocarcinoma ( PDAC ) cells . Positive_regulation IL8 TNFSF10 23392805 2739936 Overexpression of TRAF2 or Bcl-xL strongly increased *mediated* upregulation of uPA and [IL-8] . Positive_regulation IL8 TNFSF10 23392805 2739940 In PDAC cells , strongly *induced* uPA and [IL-8] via TRAIL-R1 . Positive_regulation IL8 TP63 15126418 1244846 These findings suggest that would *regulate* the cell adhesive property through ICAM-1/LFA-1 interaction and the production of IL-6 and [IL-8] , probably in all TEC subtypes . Positive_regulation IL9 ABCG2 20846001 2375410 In conclusion , [interleukin-1ß] and tumor necrosis factor-a *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation IL9 CCL17 22057112 2540329 *promoted* Toll-like receptor induced secretion of [interleukin-12] and interleukin-23 by DCs in an autocrine manner , promoted differentiation of Th1 and Th17 cells , and reduced induction of Foxp3 ( + ) Treg cells . Positive_regulation IL9 CD14 15456540 1301192 there were also synergistic effects on inhibiting [IL-12P40] production and *inducing* and CD64 expressions by monocytes . Positive_regulation IL9 DAPK1 24220855 2897458 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein NLRP3 , to promote glycolysis , influence microtubule dynamics , and enhance [interleukin-1ß] production , respectively . Positive_regulation IL9 EPHB2 12609986 1085305 activation is *required* for double stranded RNA- and virus induced [interleukin-1] expression by macrophages . Positive_regulation IL9 EPHB2 18310510 1904171 Resveratrol inhibits high glucose induced *dependent* [interleukin-17] expression in primary mouse cardiac fibroblasts . Positive_regulation IL9 F3 7635444 317294 [Interleukin-1] also upregulates expression and processing of beta-amyloid precursor proteins ( beta-APPs ) ( thus favoring beta-amyloid deposition ) and *induces* expression of alpha 1-antichymotrypsin , , the complement protein C3 , and apolipoprotein E , all of which are present in neuritic plaques . Positive_regulation IL9 IL1B 10984364 732178 We also investigated the *role* of and TNF-alpha in the release of [IL-9] from human peripheral blood eosinophils . Positive_regulation IL9 IL1B 14617515 1200650 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Positive_regulation IL9 IL1B 16375968 1547166 These results suggest that the central *activation* of [interleukin-1] receptors by is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration , hyperosmolarity and hypovolemia . Positive_regulation IL9 IL1R2 8387521 218048 A chimeric type II/type I can *mediate* [interleukin-1] induction of gene expression in T cells . Positive_regulation IL9 PGC 22117073 2535024 Overexpression of , at least partially through IL1Rn , *suppressed* [interleukin] 1ß-induced expression of acute phase proteins , C-reactive protein , and haptoglobin . Positive_regulation IL9 SCIN 9671468 519922 Murine ( D5 ) , a novel member of the gelsolin family , and murine adseverin are *induced* by [interleukin-9] in T-helper lymphocytes . Positive_regulation IL9 STAT4 7638186 317689 [Interleukin] 12 *induces* tyrosine phosphorylation and activation of in human lymphocytes . Positive_regulation IL9 TLR7 12045249 950129 Interferon-alpha and [interleukin-12] are *induced* differentially by ligands in human blood dendritic cell subsets . Positive_regulation IL9 TLR7 18312842 1879522 Toxoplasma profilin is essential for host cell invasion and dependent *induction* of an [interleukin-12] response . Positive_regulation IL9 TLR7 19430534 2077898 Moreover , *dependent* IL6 and [IL12P40] production induced by lipopolysaccharide (LPS) , R837 or CpG ODN 1826 was reduced in IRF-5 ( P68 ) expressing cells as compared to the control cells . Positive_regulation IL9 TLR7 20632067 2368023 Involvement of xanthine oxidase and hypoxia-inducible factor 1 in mediated *activation* of caspase 1 and [interleukin-1ß] . Positive_regulation IL9 TLR7 22521509 2613649 signaling *triggers* the transcriptional activation of [pro-interleukin-1ß] ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome . Positive_regulation IL9 TLR7 23246311 2732217 recognizes T. gondii profilin ( TgPRF ) and is *required* for [interleukin-12] production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice . Positive_regulation IL9 TNF 10984364 732177 We also investigated the *role* of IL-1beta and in the release of [IL-9] from human peripheral blood eosinophils . Positive_regulation IL9 TNF 11741746 897693 Similarly , also *caused* a moderate increased expression of different anti-inflammatory cytokines such as [IL-9] ( 104 % ) , IL-10 ( 24 % ) and IL-15 ( 47 % ) . Positive_regulation IL9 TNF 1463043 206778 [Interleukin-1] was *detected* in seven of 16 vitreous samples ( 44 % ) and in four of ten aqueous humor samples ( 40 % ) , whereas and interferon-gamma were never detected in vitreous or aqueous fluid . Positive_regulation IL9 TNF 17854477 1795901 CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving dependent [interleukin-12] *induction* . Positive_regulation IL9 TNF 2113076 135556 [Interleukin-1] *induces* in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation IL9 TNF 21745554 2471935 Importantly , BaP and acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as TNF-a , [interleukin-1ß] and interleukin-6 . Positive_regulation IL9 TNF 2370931 138359 Recombinant *stimulates* [interleukin-1] production in glomerular cultures from rats with nephrotoxic serum nephritis . Positive_regulation IL9 TNF 3011946 59768 interacts with endothelial cell receptors to *induce* release of [interleukin] 1 . Positive_regulation IL9 TNF 3486658 59967 *stimulates* [interleukin-1] and prostaglandin E2 production in resting macrophages . Positive_regulation IL9 TNF 3486658 60021 *causes* an increase in the production of [interleukin-1] and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M . Positive_regulation IL9 TNF 3486936 60110 Tumor necrosis factor ( ) is an endogenous pyrogen and *induces* production of [interleukin] 1 . Positive_regulation IL9 TNF 3500495 80719 No *induced* production of [interleukin] 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures . Positive_regulation IL9 TNF 3526909 62660 Endotoxin and *induce* [interleukin-1] gene expression in adult human vascular endothelial cells . Positive_regulation IL9 TNF 7506142 237756 The release of *initiates* the release of [interleukin-1] and interleukin-8 , which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines , respectively . Positive_regulation IL9 TNF 7737374 305528 Diminished responsiveness of senescent normal human fibroblasts to *dependent* proliferation and [interleukin] production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B . Positive_regulation IL9 TNF 8132326 251534 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances and *induces* [interleukin-1] production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation IL9 TNF 8592105 341924 *induces* substance P in sympathetic ganglia through sequential induction of [interleukin-1] and leukemia inhibitory factor . Positive_regulation IL9 TNF 8592105 341979 The present study establishes that induction of sympathetic substance P ( SP ) *requires* sequential induction of both [interleukin] ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation IL9 TNF 8910536 395221 Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an [interleukin-1and] *mediated* stimulation of macrophage colony stimulating factor production . Positive_regulation ILK ANGPT1 18502941 1939397 *increased* [integrin linked kinase] , a key regulator of integrin signaling and cardiac health . Positive_regulation ILK ANKRD1 15872073 1426162 Overexpression of the PINCH-1 binding of ILK but not that of a PINCH-1 binding defective mutant form of the ankyrin domain effectively *inhibited* the formation of the [PINCH-1-ILK-alpha-parvin] complex . Positive_regulation ILK CTGF 17498677 1744473 Role of ERK1/2 and PI3-K in the regulation of *induced* [ILK] expression in HK-2 cells . Positive_regulation ILK CTGF 17498677 1744484 Induction of [ILK] in *response* to was studied at the mRNA level by real-time PCR and protein by immunoblotting . Positive_regulation ILK CTGF 17498677 1744509 Chemical inhibitors were used to assess the role of MEK/ERK1/2 , PI3-K , and P38 MAPK signaling pathways in *induction* of [ILK] by . Positive_regulation ILK CTGF 17498677 1744554 *induced* [ILK] protein expression in HK-2 cells in a time- and dose dependent manner . Positive_regulation ILK CTGF 17498677 1744555 *induced* [ILK] expression was partially reduced by inhibiting ERK1/2 and PI3-K activation . Positive_regulation ILK CTGF 17498677 1744560 *induces* the expression of [ILK] protein in HK-2 cells . Positive_regulation ILK CTGF 21913214 2524872 Of note , the upregulation of [ILK] induced by high glucose was partially *blocked* by the inhibition of . Positive_regulation ILK EPHB2 23511142 2757022 AngII increased the activity of protein kinase C-dependent phosphatase inhibitor of 17-kD ( CPI17 ) , integrin linked kinase (ILK) , and zipper interacting protein kinase (ZIPK) , The effect of AngII on CPI17 was blocked by ERK and p38 MAPK inhibitor , while the effect of AngII on [ILK] and ZIPK was only *blocked* by inhibitor . Positive_regulation ILK IL1B 19134459 2025400 Compared with the blank control group , might induce TEMT , which was showed in increasing expression of alpha-SMA , increasing secreting of FN and decreasing expression of E-cadherin , and at the same time the expressions of TGF-beta1 and [ILK] were *enhanced* ( P < 0.05 ) . Positive_regulation ILK MAP2K6 17498677 1744515 Chemical inhibitors were used to assess the *role* of , PI3-K , and P38 MAPK signaling pathways in induction of [ILK] by CTGF . Positive_regulation ILK TNF 20135642 2235884 Stimulation of cells with *increased* [ILK] kinase activity . Positive_regulation ILK TNS1 15030759 1223167 The localization of *requires* integrins , talin , and [integrin linked kinase] . Positive_regulation ILKAP CCND1 23329845 2747066 We also found that nuclear [ILKAP] interacts with ribosomal protein S6 kinase-2 (RSK2) and *induces* apoptosis by inhibiting RSK2 activity and down regulating the expression level of the RSK2 downstream substrate . Positive_regulation IMPA1 S100B 19593677 2122892 IMPA1 is regulated by another calcium binding protein calbindin-D28k (CaB) , since we reported earlier that the CaB levels are reduced in SCA1 PCs , the *activation* of [IMPA1] by may modulate CaB dependent inositol signaling . Positive_regulation INCENP STK39 18083840 1837287 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation ING4 CCND1 18399550 1893746 Overexpression of [ING4] can induce growth inhibition in A549 cells both in vitro and in vivo , and also *induce* up-regulation of p27 , down-regulation of , SKP2 , and Cox2 , and inactivation of the Wnt-1/beta-catenin pathway . Positive_regulation INHBA EPHB2 17016599 1629958 In addition , ERK protein was rapidly and transiently activated with activin A in both types of CML cells , suggesting that phosphorylation of is *required* for [activin A] signaling in CML cells . Positive_regulation INHBA EPHB2 21828177 2485436 A p38 MAPK inhibitor , SB202190 , a kinase inhibitor , U0126 , and an nuclear factor ?B pathway inhibitor , SC-514 , significantly *suppressed* the IL-1ß stimulated [INHBA] and FST mRNA expression . Positive_regulation INHBA IL1B 11035281 741071 In amnion explants , [activin A] production was *stimulated* by and TNF-alpha to 450 +/- 155.4 % and 531 +/- 170.8 % of control , respectively ( mean +/- standard error of the mean ; Positive_regulation INHBA IL1B 11581011 865480 [Activin A] secretion was *increased* in culture in a dose dependent manner by ( approximately 150 % , P < 0.05 ) , TNF-alpha ( approximately 35 % , P=0.02 ) and GMCSF ( approximately 100 % , P < 0.01 ) . Positive_regulation INHBA IL1B 11678900 873731 Here we show that bone marrow derived stromal fibroblasts are the major source of activin A and FS in the bone marrow , and that the production of [activin A] is *enhanced* by and lipopolysaccharide (LPS) , whereas interferon-gamma (IFN-gamma) inhibits the secretion of activin A by stromal fibroblasts . Positive_regulation INHBA IL1B 1417851 201708 In a human bone marrow derived stromal cell line , KM-102 , phorbol myristate acetate , tumor necrosis factor-alpha and induced great *increases* in beta A chain mRNA levels and production of [activin A] activities . Positive_regulation INHBA IL1B 15941932 1415648 In the secretion study , [activin A] secretion at 8-10 weeks was significantly *stimulated* by and EGF . Positive_regulation INHBA IL1B 9699965 525173 Both and TNF-alpha *stimulated* [activin-A] production in a concentration dependent fashion in all cultures ; Positive_regulation INHBA TF 7867593 296462 In the *presence* of insulin and , [activin-A] increased both granulosa cell number and thymidine incorporation more than 2-fold . Positive_regulation INHBA TNF 11035281 741070 In amnion explants , [activin A] production was *stimulated* by IL-1 beta and to 450 +/- 155.4 % and 531 +/- 170.8 % of control , respectively ( mean +/- standard error of the mean ; Positive_regulation INHBA TNF 11581011 865478 [Activin A] secretion was *increased* in culture in a dose dependent manner by IL-1beta ( approximately 150 % , P < 0.05 ) , ( approximately 35 % , P=0.02 ) and GMCSF ( approximately 100 % , P < 0.01 ) . Positive_regulation INHBA TNF 1417851 201678 and interleukin-1 *induce* [activin A] gene expression in a human bone marrow stromal cell line . Positive_regulation INHBA TNF 1417851 201707 In a human bone marrow derived stromal cell line , KM-102 , phorbol myristate acetate , and interleukin-1 beta *induced* great increases in beta A chain mRNA levels and production of [activin A] activities . Positive_regulation INHBA TNF 14671202 1178361 Both endotoxin and *stimulated* [activin A] secretion by PBMCs from nonpregnant , preeclamptic , and matched normal pregnant women ( P < 0.05 ) . Positive_regulation INHBA TNF 15893868 1481295 On the other hand , secretion significantly *increased* in presence of [activin A] but not of inhibin A . Positive_regulation INHBA TNF 21640344 2450994 [Activin-A] is *induced* by interleukin-1ß and and enhances the mRNA expression of interleukin-6 and protease activated receptor-2 and proliferation of stromal cells from endometrioma . Positive_regulation INHBA TNF 21640344 2451024 An in vitro study revealed that [activin-A] , which is *induced* by IL-1ß or , might promote endometriosis by stimulating IL-6 and PAR-2 mRNA expression and increasing the proliferation of EoSC . Positive_regulation INHBA TNF 23116663 2717434 Release of [activin A] from isolated BMNPs was *stimulated* by , but this was not due to increased activin A production . Positive_regulation INHBA TNF 23385491 2818516 [Activin A] is *stimulated* by and modulates collagen gene expression in human amniotic cells . Positive_regulation INHBA TNF 23385491 2818518 and lipopolysaccharide *stimulated* [activin A] production in amniotic epithelial cells , and activin A modulated expression of collagen mRNA in amniotic mesenchymal cells . Positive_regulation INHBA TNF 9699965 525172 Both IL-1beta and *stimulated* [activin-A] production in a concentration dependent fashion in all cultures ; Positive_regulation INHBB INHBA 17649814 1775862 [Inhibin-alpha and -betaB] were not *detected* , while was expressed in all adenosquamous carcinomas . Positive_regulation INHBB INS 19491194 2136179 In differentiated 3T3-L1 adipocytes , where receptors to activin have been previously reported , *increases* the expression of [INHBB] , while dexamethasone decreases the expression of INHBB when compared with untreated control cells . Positive_regulation INHBB MIR34A 21655280 2442315 *mediated* regulation of [INHBB] and Met may collectively contribute to the suppression of hepatocyte proliferation . Positive_regulation INMT IL1B 19134459 2025395 To study the effects of transforming growth factor-beta1/integrin linked kinase ( TGF-beta1/ILK ) signal way in interleukin-1beta (IL-1beta) induced rat tubular epithelial-myofibroblast transdifferentiation ( TEMT ) , and to investigate whether emodin inhibits *induced* [TEMT] through the TGF-beta1/ILK signal way dependent mechanism . Positive_regulation INMT IL1B 19134459 2025401 Compared with the blank control group , might *induce* [TEMT] , which was showed in increasing expression of alpha-SMA , increasing secreting of FN and decreasing expression of E-cadherin , and at the same time the expressions of TGF-beta1 and ILK were enhanced ( P < 0.05 ) . Positive_regulation INMT IL1B 19134459 2025402 Compared with emodin inhibited group , emodin-pretreatment could not prevent IL-1beta induced-TEMT in a certain extent , but emodin could not revert *induced* [TEMT] . Positive_regulation INMT IL1B 19134459 2025403 IL-1beta induces TEMT partly depending on TGF-beta1/ILK signal way , partly via which emodin inhibits the [TEMT] *induced* by . Positive_regulation INPP1 CAPN8 22673904 2611358 Allergic airway inflammation in mice led to *mediated* degradation of [inositol polyphosphate-4-phosphatase] . Positive_regulation INPP3 CAPN8 22673904 2611372 Allergic airway inflammation in mice led to *mediated* degradation of [inositol polyphosphate-4-phosphatase] . Positive_regulation INPP4B AR 21224358 2379457 Optimal *induction* of [INPP4B] by an required the expression of the transcriptional coactivator NCoR . Positive_regulation INPP4B CORO2A 21224358 2379453 Optimal induction of [INPP4B] by an androgen receptor *required* the expression of the transcriptional coactivator . Positive_regulation INPP4B EPHB2 22895072 2692355 Taken together , our data suggest that dependent *induction* of [INPP4B] triggers the development of a tumor-resistance phenotype via Akt signaling and identify INPP4B as a potentially important target molecule for resolving the radioresistance of cancer cells . Positive_regulation INPP4B GPS2 21224358 2379455 Optimal induction of [INPP4B] by an androgen receptor *required* the expression of the transcriptional coactivator . Positive_regulation INPP4B HDAC3 21224358 2379456 Optimal induction of [INPP4B] by an androgen receptor *required* the expression of the transcriptional coactivator . Positive_regulation INPP4B NCOR1 21224358 2379458 Optimal induction of [INPP4B] by an androgen receptor *required* the expression of the transcriptional coactivator . Positive_regulation INPP4B TBL1X 21224358 2379452 Optimal induction of [INPP4B] by an androgen receptor *required* the expression of the transcriptional coactivator . Positive_regulation INPP4B TBL1XR1 21224358 2379454 Optimal induction of [INPP4B] by an androgen receptor *required* the expression of the transcriptional coactivator . Positive_regulation INS ADRB2 1337737 208043 It might also exhibit a negative feedback inhibition on *induced* [insulin] secretion , but has little influence on glucose induced insulin release . Positive_regulation INS ADRB2 14693408 1194883 Further studies of the expression of the allelic receptor in islet cells may help to resolve the *role* of in [insulin] secretion . Positive_regulation INS ADRB2 3030608 67851 *induced* increase of plasma [insulin] levels in man : evidence of direct and indirect B-cell stimulation and liver effects . Positive_regulation INS ARSA 3905478 53640 When in healthy subjects arterial plasma glucose was acutely raised and maintained at +7 mmol/l above fasting level , the plasma [insulin] response was *enhanced* by ( 70 +/- 7 vs. 52 +/- 7 mU/l ) , whereas the plasma C-peptide response was identical . Positive_regulation INS ARSA 6349864 30413 Thus , *enhances* glucose induced secretion of [insulin] in type II diabetics but fails to potentiate the glucose dependent suppression of arginine stimulated growth hormone release . Positive_regulation INS ARSA 6757082 24100 The prostaglandin synthesis inhibitor *increases* acute [insulin] response to glucose and improves glucose tolerance in man . Positive_regulation INS CA12 9733757 530996 Expression of carbonic anhydrase V in pancreatic beta cells suggests *role* for mitochondrial in [insulin] secretion . Positive_regulation INS CABP4 8119959 250690 The Ca ( 2+ ) -stimulated [insulin] release was *enhanced* by calcyclin , in a dose dependent manner , whereas this had no effect on insulin release from islets in low Ca2+ buffer or from the islets not subjected to the streptolysin-O treatment . Positive_regulation INS CAPN8 12759879 1091297 In summary , long-term inhibition of islet activity *attenuates* [insulin] secretion possibly by limiting the rate of glucose metabolism . Positive_regulation INS CAPN8 15877869 1405871 Lactacystin and calpain inhibitor I , but not isovaleryl-L-carnitine , raised insulin secretion in control islets , indicating that proteasome and cysteinyl cathepsin(s) , but not , are *involved* in fetal [insulin] secretion . Positive_regulation INS CCND1 24870244 2945655 [Insulin/GSK-3ß] ( glycogen synthase kinase 3-beta ) signalling *induces* protein stability by sequestering cyclin D1 in the nucleus . Positive_regulation INS CLU 23515283 2772224 Adenovirus mediated overexpression of *inhibited* [insulin-] or LXR agonist stimulated SREBP-1c expression in cultured liver cells . Positive_regulation INS EDN2 1559985 184651 Thus the selective interactions within the G protein system that couples the endothelin receptor to phospholipase C are potential sites at which the v-src transformation process may act to amplify *dependent* [Ins] ( 1,4,5 ) P3 production . Positive_regulation INS EDN2 8412756 233695 [Insulin] at a concentration of 80 microU/mL did not *induce* a significant increase of spontaneous immunoreactive release , but significantly increased the effects of arginine vasopressin ( P < .05 ) . Positive_regulation INS EDN2 8425673 211039 [Insulin] *stimulates* production and secretion of from bovine endothelial cells . Positive_regulation INS EPHB2 10347117 616723 [Insulin] and IGF-1 *induced* 70-kd S6 kinase phosphorylation in HSC , whereas IGF-1 only induced phosphorylation . Positive_regulation INS EPHB2 12887130 1116905 [Insulin] *induced* phosphorylation in a dose dependent manner in VSMC . Positive_regulation INS EPHB2 15344880 1292100 In these R- cells , PI3K inhibition by LY294002 enhanced insulin stimulation of phosphorylation whereas LY294002 *inhibited* [insulin] stimulation of Akt phosphorylation . Positive_regulation INS EPHB2 16210359 1501022 These results suggest that both and PI3 kinase signaling are *involved* in [insulin] stimulated granulosa cell proliferation . Positive_regulation INS EPHB2 19429364 2077615 Specific inhibitor PD98059 *inhibited* the increase of [insulin] secretion by Angelica hirsutiflora extract in HIT-T15 cells and isolated mouse islets . Positive_regulation INS EPHB2 19502797 2098142 Concomitantly , [insulin] stimulation *induced* Raf-1 and activation , followed by thymidine uptake . Positive_regulation INS EPHB2 20517899 2271049 To explore the mechanisms of action of insulin on osteoblast growth and differentiation , human osteoblastic cell line-MG-63 was used and stimulated by [insulin] in the *presence* or absence of inhibitor PD98059 , PI3-K inhibitor LY294002 , or inhibitor PD98059 + LY294002 . Positive_regulation INS EPHB2 20709750 2335572 Adiponectin induced and Akt phosphorylation protects against pancreatic beta cell apoptosis and *increases* [insulin] gene expression and secretion . Positive_regulation INS EPHB2 21673097 2455363 [Insulin] secretion in response to estradiol and G-1 was *dependent* on epidermal growth factor receptor and activation and further modulated by phosphatidylinositol 3-kinase activity . Positive_regulation INS EPHB2 21998735 2493821 [Insulin] release was *dependent* upon nutrient induced activation of calcium/calmodulin dependent protein kinase II ( CaMKII ) and extracellular signal regulated kinase ( ) as their pharmacological inhibition suppressed GSIS/AASIS significantly . Positive_regulation INS EPHB2 21998735 2493822 Our results exclude changes in ceramide content or mitochondrial fatty acid handling as factors initiating palmitate induced defects in insulin release from MIN6 ß cells , but suggest that reduced CaMKII and activation associated with palmitate overload may *contribute* to impaired stimulus induced [insulin] secretion . Positive_regulation INS EPHB2 22194983 2518674 [Insulin] *induced* the activation of extracellular signal regulated kinase ( ) 1/2 , mitogen activated protein kinase (MAPK) and RAC-alpha serine/threonine-protein kinase ( Akt ) . Positive_regulation INS EPHB2 23948373 2861842 We compared the [insulin] *activation* of PI3K-Akt ( glucose uptake ) and ( pro-inflammation ) signaling pathways , intracellular and mitochondrial oxidative stress ( DCF and MitoSOX Red ) , and their responses to the antioxidant N-acetylcysteine (NAC) . Positive_regulation INS EPHB2 24575365 2919979 Insulin stimulated glucose transport and [insulin] *activation* of in adipocytes of wild-type mice were similarly inhibited by acute inhibition of PKC-? with a highly-specific chemical inhibitor . Positive_regulation INS EPHB2 8940056 398804 The temporal relationship between the activation of ERK , JNK , p38 and the downstream elements p90 ( rsk ) and PP-1 in vivo suggest that JNK , but neither nor p38 MAPKs , *mediates* [insulin] activation of glycogen synthase in vivo . Positive_regulation INS FAS 10744693 680673 This study demonstrates that the sequence requirement for gene regulation employing an in vitro culture system does not reflect the in vivo situation and that two 5'-flanking regions are *required* for proper nutritional and [insulin] regulation of the FAS gene . Positive_regulation INS FAS 17130640 1653048 For the pancreatic beta-cell , while the presence of some is *essential* for glucose stimulated [insulin] secretion , FAs have enormous capacity to amplify glucose stimulated insulin secretion , which is particularly operative in situations of beta-cell compensation for insulin resistance . Positive_regulation INS FAS 19843871 2299417 These data demonstrate that differently *regulate* amylin and [insulin] expression and induce both amylin and insulin release . Positive_regulation INS FAS 21098489 2377285 [Insulin] *induced* in endothelial cells freshly isolated from humans , and eNOS palmitoylation was decreased in mice with insulin-deficient or insulin-resistant diabetes . Positive_regulation INS FOXA1 19445897 2090617 *Role* of in mitochondrial citrate carrier gene expression and [insulin] secretion . Positive_regulation INS FOXO1 11696581 877505 These findings are consistent with the possibility that is *involved* in [insulin] regulation of glucose production by mediating the ability of insulin to decrease the glucocorticoid/cAMP response of G6p . Positive_regulation INS FOXO1 15934941 1414680 , a member of the FoxO subfamily of forkhead transcription factors , is an important *target* for [insulin] and growth factor signaling in the regulation of metabolism , cell cycle and proliferation , and survival in peripheral tissues . Positive_regulation INS FOXO1 16870142 1593047 Adenoviral mediated overexpression of forkhead transcription factor increased angptl4 mRNA expression , and [insulin] significantly *suppressed* its effect . Positive_regulation INS FOXO1 16885156 1613822 [Insulin] regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes : *roles* of and sterol regulatory element binding protein 1c . Positive_regulation INS FOXO1 17408630 1728353 Platelet derived growth factor ( PDGF ) or [insulin] phosphorylates FoxO1 and *induces* translocation from the nuclei to the cytosol via the PI3K/AKT pathway in HSCs . Positive_regulation INS FOXO1 18282106 1896459 Long lived daf-2 [insulin/IGF-1] receptor mutants *require* both autophagy and the transcription factor for their longevity , but we find that autophagy takes place in the absence of DAF-16 . Positive_regulation INS FOXO1 19246449 2062623 [Insulin] *induces* phosphorylation and nuclear exportation , which prevents FoxO1-PPARgamma interactions and rescues transrepression . Positive_regulation INS FOXO1 20501674 2294828 Increased activity *augments* the expression of [insulin receptor (IR)] and IR substrate (IRS)2 , which in turn inhibits FoxO1 activity in response to reduced insulin action . Positive_regulation INS FOXO1 21298325 2425820 [Insulin] *induced* nuclear exit and Thr24 phosphorylation of , thus , inhibiting STAT3 mediated transcription . Positive_regulation INS FOXO1 21335550 2411095 Nucleo-cytosolic shuttling of directly *regulates* mouse [Ins2] but not Ins1 gene expression in pancreatic beta cells ( MIN6 ) . Positive_regulation INS FOXO1 21518241 2449086 Although extensively studied in Caenorhabditis elegans , no work has yet demonstrated for Drosophila melanogaster whether reduced [insulin/IGF signaling (IIS)] *requires* the to extend lifespan . Positive_regulation INS FOXO1 23147115 2803360 The aim of this study was to evaluate whether dysregulation of molecules involved in *dependent* [insulin] signaling in the liver is associated with de novo lipogenesis (DNL) and altered lipid metabolism in severely obese subjects . Positive_regulation INS FUT4 1731959 181423 Thyroxine and [insulin] , injected into suckling rats , did not *induce* significant modifications of the activity , under the conditions used , whereas this enzyme activity was highly enhanced after administration of glucocorticoids ( cortisone and hydrocortisone ) . Positive_regulation INS GLP1R 20690636 2311970 Activation of the ( GLP-1R ) upon ligand binding *leads* to the release of [insulin] from pancreatic cells . Positive_regulation INS GLP1R 21771891 2467188 However , loss of *impaired* first-phase [insulin] secretion in mice with or without liver-specific G ( s ) a deficiency . Positive_regulation INS GLP1R 21820006 2495540 However , despites of plethora of rigorous studies , molecular mechanisms underlying how GIPR and activation *leads* to enhancement of glucose dependent [insulin] secretion are still largely unknown . Positive_regulation INS GLP1R 22101168 2541014 To explore the *role* of the ( GLP-1R ) in geniposide regulated [insulin] secretion in rat INS-1 insulinoma cells . Positive_regulation INS GLP1R 22776039 2715524 *activated* [insulin] secretion from pancreatic ß-cells : mechanism and glucose dependence . Positive_regulation INS GLP1R 22776039 2715525 This review aims to discuss the current understanding of the mechanisms by which signalling *promotes* [insulin] secretion from pancreatic ß-cells via a glucose dependent process . Positive_regulation INS GLP1R 24326362 2894891 would be a diagnostic marker of insulinoma and might become a molecular *target* for treatment of metastatic PNETs and hormonal regulation of [insulin] . Positive_regulation INS GPR115 12475788 1023646 Glucagon-like peptide-1 (GLP-1) acts through its to *enhance* glucose stimulated [insulin] secretion from pancreatic beta-cells . Positive_regulation INS GPR115 23211512 2730919 Pancreatic ß-cells regulate glucose homeostasis by secreting [insulin] in *response* to glucose elevation and activation . Positive_regulation INS GPR115 23331570 2775487 fatty acid receptor 1 ( GPR40/FFAR1 ) *regulates* free fatty acid induced [insulin] secretion . Positive_regulation INS GPR115 24666736 2930643 GPR40 is a regulating free fatty acid induced and also glucose *induced* [insulin] secretion . Positive_regulation INS GPR132 12475788 1023635 Glucagon-like peptide-1 (GLP-1) acts through its to *enhance* glucose stimulated [insulin] secretion from pancreatic beta-cells . Positive_regulation INS GPR132 23211512 2730908 Pancreatic ß-cells regulate glucose homeostasis by secreting [insulin] in *response* to glucose elevation and activation . Positive_regulation INS GPR132 23331570 2775476 fatty acid receptor 1 ( GPR40/FFAR1 ) *regulates* free fatty acid induced [insulin] secretion . Positive_regulation INS GPR132 24666736 2930632 GPR40 is a regulating free fatty acid induced and also glucose *induced* [insulin] secretion . Positive_regulation INS GPR87 12475788 1023715 Glucagon-like peptide-1 (GLP-1) acts through its to *enhance* glucose stimulated [insulin] secretion from pancreatic beta-cells . Positive_regulation INS GPR87 23211512 2730988 Pancreatic ß-cells regulate glucose homeostasis by secreting [insulin] in *response* to glucose elevation and activation . Positive_regulation INS GPR87 23331570 2775557 fatty acid receptor 1 ( GPR40/FFAR1 ) *regulates* free fatty acid induced [insulin] secretion . Positive_regulation INS GPR87 24666736 2930712 GPR40 is a regulating free fatty acid induced and also glucose *induced* [insulin] secretion . Positive_regulation INS HBEGF 17274952 1697427 [Insulin] *induces* a transcriptional activation of epiregulin , and amphiregulin , by a PI3K dependent mechanism : identification of a specific insulin-responsive promoter element . Positive_regulation INS HBEGF 17472728 1738295 These findings demonstrate that amino-terminally truncated , membrane bound form of HB-EGF stimulates cell proliferation but lacks insulin-like signalling , suggesting that [insulin-like] signalling is *mediated* by soluble , mature binding to EGF receptors . Positive_regulation INS HRH1 8708938 371233 These results indicate that activation of *induces* the accumulation of [Ins] ( 1,4,5 ) P3 and the following transient increase in [Ca2+ ] i , and elicits the release of PGE2 which may be coupled with Ca2+ influx . Positive_regulation INS HSD11B2 9399631 469190 It is being concluded , that both glucocorticoids and mineralocorticoids but not [insulin] or triiodothyronine *induce* intestinal <11betaHSD> activity . Positive_regulation INS ID1 21940780 2487659 Here , we investigated the *role* of in [insulin] secretion and glucose homeostasis . Positive_regulation INS IGFBP1 12042554 949816 If intrauterine growth is related to the risk of developing adult diseases , IGF-I , , and leptin may be *involved* in the underlying processes.1131-1135 [insulin] like growth factors , leptin , umbilical cord plasma , birth weight . Positive_regulation INS IGFBP1 1379161 192763 However , in the presence of epidermal growth factor ( which was without independent effect on the 30-kDa IGFBP ) , [insulin] also *induced* this 30-kDa . Positive_regulation INS IGFBP1 17693389 1788583 In contrast , *augmented* glucose stimulated [insulin] secretion in intact islets , associated with a reduced somatostatin secretion . Positive_regulation INS IGFBP1 9420884 345301 Octreotide treatment also did not change serum IGF-I levels in either group , but serum [insulin] levels decreased significantly and levels *increased* significantly in both groups ; Positive_regulation INS IL1B 10967106 751783 The decrease in glucose stimulated [insulin] secretion *induced* by and IFN-gamma was however not prevented . Positive_regulation INS IL1B 1535517 190959 Furthermore , cycloheximide , an inhibitor of protein synthesis , could also prevent the early *induced* stimulation of [insulin] release . Positive_regulation INS IL1B 15831571 1417983 Finally , a chelator of intracellular free Ca ( 2+ ) [ bis- ( o-aminophenoxy ) -N , N,N ' , N'-tetraacetic acid-acetoxymethyl ] , an inhibitor of calmodulin ( W7 ) , and inhibitors of Ca ( 2+ ) /calmodulin dependent kinase ( KN62 and KN93 ) partially reduced *stimulated* c-jun phosphorylation in [INS-1] or betaTC3 cells . Positive_regulation INS IL1B 16023781 1441613 In iNOS-/- islets , at high glucose *induced* a delayed and prolonged stimulation of [insulin] secretion , and this was followed by an increase in phospholipase D mRNA expression . Positive_regulation INS IL1B 16441241 1540534 *caused* an enhancement of islet intracellular [insulin] degradation and an increase in the lysosomal incorporation of beta-cell secretory granules . Positive_regulation INS IL1B 1720090 171635 Moreover , the nitric oxide synthase inhibitor NG-monomethyl-L-arginine ( Meth-arg ; 5 mM ) failed to prevent the initial ( 90 min ) *induced* increase in islet [insulin] release . Positive_regulation INS IL1B 1720090 171637 The presence of actinomycin-D during the 1-h IL-1 beta incubation period prevented the IL-1 beta induced rise in nitrite production and the *induced* inhibition of aconitase activity and [insulin] release . Positive_regulation INS IL1B 19763396 2158874 We demonstrate that SOCS-1 does not prevent increase in NO production and decrease in glucose stimulated [insulin] secretion in the *presence* of , IFNgamma , TNFalpha . Positive_regulation INS IL1B 2035711 159711 These results indicate that , although sleep is disturbed in diabetic rats , pancreatic [insulin] might not have a decisive role in the regulation of sleep in rats , and it does not *mediate* the effects of on sleep-wake activity . Positive_regulation INS IL1B 21158055 2182029 *induced* a significant decrease of cell activity and [insulin] release , flow cytometry analysis showed that apoptotic percentage of islet cells remarkably increased following the addition of IL-1beta , FDP obviously improved the islets cellular activity damaged by IL-1beta , and basic amount of insulin secretion and stimulated by high glucose were improved ( P < 0.01 ) . Positive_regulation INS IL1B 2137789 128804 In the short-term , *induced* a dosage dependent stimulation of [insulin] release . Positive_regulation INS IL1B 2199215 138238 In the short-term ( 1 h ) , 25 U/ml significantly *increased* the rates of [insulin] release and glucose utilisation , but not glucose oxidation . Positive_regulation INS IL1B 2406177 128065 *stimulated* [insulin] secretion at 11 and 20 mmol/l D-glucose and potentiated first as well as second phase insulin release in a dose dependent fashion , with decreasing effect at higher concentrations . Positive_regulation INS IL1B 2687062 122639 Human *induced* stimulation of [insulin] release from rat pancreatic islets is accompanied by an increase in mitochondrial oxidative events . Positive_regulation INS IL1B 7556877 323432 *induced* stimulation of [insulin] release in mouse pancreatic islets is related to diacylglycerol production and protein kinase C activation . Positive_regulation INS IL1B 8070306 270025 Pretreatment of the islets by human lysozyme does not prevent the reduction of the [insulin] secretion *induced* by . Positive_regulation INS IL1B 8922366 397138 Therefore , the INS-1 cells were still able to respond to glucose stimulation with a 1.8-2.0-fold increase in [insulin] release in either the *presence* or absence of . Positive_regulation INS IRS4 1712770 161254 These results provide further evidence for a *role* of in [insulin] signaling . Positive_regulation INS ITGB2 24915517 2952162 [Insulin] *induced* surface expression of , and neutralization of Mac-1 blocked insulin induced adhesion of THP-1 as well as BDMCs . Positive_regulation INS JAG1 9338087 345210 *had* no effect on resting plasma levels of hGH , [insulin] or cortisol . Positive_regulation INS KCP 16316644 1490859 In isolated islets , also *enhanced* [insulin] secretion in a dose- and a glucose-concentration dependent manner . Positive_regulation INS KCP 16316644 1490860 Plasma levels of insulin after glucose challenge in KCP256 administrated rats were higher than those in vehicle administrated animals , indicating that can *enhance* [insulin] secretion in vivo . Positive_regulation INS MAP2K6 10229678 611065 We found that this transcription is regulated in the MIN6 cells in the same range of glucose concentration as in primary islets , and that specific inhibition of , the direct activator of ERK , *impaired* the response of the [insulin] gene to glucose . Positive_regulation INS MAP2K6 16542348 1537195 Besides , *repression* of [insulin] signalling by either PI-3K or inhibitor diminished expression of selected subunits of the mitochondrial oxidative phosphorylation enzymes ( OXPHOS ) . Positive_regulation INS MAP2K6 22521266 2630836 Mutation of two ERK phosphorylation sites on MKP-3 rendered it resistant to [insulin] and constitutively active *induced* MKP-3 protein degradation . Positive_regulation INS MAP2K6 23217386 2707864 This study was to investigate the *roles* of ( MEK) 1 and 2 in the regulation of human [insulin-] and insulin glargine induced proliferation of human bladder cancer T24 cells . Positive_regulation INS MAP2K6 7706312 297734 The first activator has an apparent M ( r ) of 40,000-50,000 , was immunologically distinct from A-Raf , B-Raf , c-Raf-1 , c-MEKK , c-Mos , MEK1 , and MEK2 , and was rapidly *activated* by serum , platelet derived growth factor ( PDGF ) , [insulin] , thrombin , and phorbol ester . Positive_regulation INS MAP2K6 8995239 409394 The specific inhibitor , PD98059 , *inhibited* [insulin] but not bpV ( phen ) -stimulated MAP kinase activity , suggesting that MAP kinases can be activated in a MEK independent fashion . Positive_regulation INS MAP2K6 9645686 514752 [Insulin] induction of protein kinase C alpha expression is independent of insulin receptor Tyr1162/1163 residues and *involves* 1 and sustained activation of nuclear p44MAPK . Positive_regulation INS MAP2K6 9843380 553036 [Insulin] *induced* phosphorylation and activation of p38 MAP kinase whose activity was inhibited with SB203580 . Positive_regulation INS MSX1 8620859 354108 Neither IGF-I , [insulin] nor FGFs *induce* expression of the homeobox containing gene in the subapical mesoderm of wl or ll limb buds , although FGFs , but not IGF-I or insulin , maintain Msx-1 expression in normal ( non-mutant ) limb bud explants lacking an AER . Positive_regulation INS NES 19224238 2050334 Using double staining , we demonstrated that Oct4 was not co-expressed with Chromogranin A ( a peptide expressed in endocrine cells ) , but partially co-expressed with Ngn3 ( a transcription factor expressed in pancreatic endocrine precursor cells ) and ( a intermediate filament , Nestin positive cells isolated from islets can be *induced* to express [insulin] ) in human fetal pancreases . Positive_regulation INS PCSK9 19878649 2165776 However , did not alter cholesterol content nor glucose *stimulated* [insulin] secretion in mouse islets . Positive_regulation INS PKP1 23444369 2781135 [Insulin] stimulation *induced* the phosphorylation of , which correlated with reduced intercellular adhesion and an increased activity of plakophilin 1 in the stimulation of translation . Positive_regulation INS RAB31 15159548 1252724 Accordingly , Noc2 positively regulates [insulin] secretion from endocrine pancreas by inhibiting Gi/o signaling , and the interaction of Noc2 and is *required* for the effect . Positive_regulation INS RASA3 9560326 500474 We conclude that the increase in [Ins] ( 2,4,5 ) P3-stimulated Ca2+ mobilization by Ins ( 1,3,4 , 5 ) P4 may be *mediated* by or a closely related protein ( such as GAP1 ( m ) ) , and if so , the action of the GAP1 is not solely to regulate GTP loading of a G-protein , but rather it acts with a G-protein to cause its effect . Positive_regulation INS RGS2 9794454 543055 These results suggest a potential *role* for in modulating GIP mediated [insulin] secretion in pancreatic islet cells . Positive_regulation INS SCIN 10973622 729067 These data suggest that might be important for controlling cortical actin network dynamics in mouse pancreatic beta-cells and that scinderin induced cortical filamentous actin disassembly is *required* for [insulin] secretion . Positive_regulation INS SPHK1 17265031 1704157 is *involved* in [insulin] signalling and plays an important role in the regulation of glucose and fat metabolism ; Positive_regulation INS SPHK1 22155656 2542800 To evaluate the *role* of in [insulin] secretion , we used stable transfection to knock down the expression of the Sphk1 gene in the rat insulinoma INS-1 832/13 cell line . Positive_regulation INS SPHK1 24376889 2883455 In contrast , prolonged inhibition of intensified the effect of PA on insulin stimulated glucose uptake and *attenuated* further the activity of [insulin] signaling proteins ( pGSK3ß/GSK3ß ratio ) in L6 myotubes . Positive_regulation INS SRGN 14559722 1186100 These data provide evidence that PRL and to a lesser extent , which increase in early pregnancy , enhance basal and glucose *stimulated* [insulin] secretion in part by increasing GK activity and amplifying cAMP levels . Positive_regulation INS TF 17912456 1803861 *increased* binding of [insulin growth factor (IGF)-1] to the activated IGF-1 receptor , and IGF-1 mimicked the invasive and adhesive effects of transferrin . Positive_regulation INS TGM2 12205028 983428 Here we show that targeted disruption of *impairs* glucose stimulated [insulin] secretion . Positive_regulation INS TGM2 1707691 147818 Ca ( 2+ ) -Induced [insulin] release from electropermeabilised islets is *inhibited* by the inhibitors monodansylcadaverine , glycine methylester , methylamine and cystamine but not by the control compounds dimethyl monodansylcadaverine and sarcosine methylester which lack the primary amine group . Positive_regulation INS TGM2 2408879 48603 *Role* of in [insulin] release . Positive_regulation INS TLR7 23568555 2783181 Recent evidence suggests that activation of signaling induces peripheral insulin resistance and *mediates* central [insulin] and leptin resistance . Positive_regulation INS TNF 10455187 638616 To investigate whether H ( 2 ) O ( 2 ) is involved in hyperglycemia- and/or *induced* [insulin] resistance , we preincubated the cells with the H ( 2 ) O ( 2 ) scavenger catalase prior to incubation with 25 mM glucose , 25 mM 2-deoxyglucose , 5.7 nM TNFalpha , or 500 microM H ( 2 ) O ( 2 ) , respectively , and subsequent insulin stimulation . Positive_regulation INS TNF 11443501 833860 significantly suppressed basal and glucose *stimulated* [insulin] secretion and proinsulin mRNA transcription in a dose dependent manner , an effect that was more powerful in the presence of high glucose . Positive_regulation INS TNF 11779863 916532 Transactivation of ErbB2 and ErbB3 by and anisomycin *leads* to impaired [insulin] signaling through serine/threonine phosphorylation of IRS proteins . Positive_regulation INS TNF 12200753 982941 In nondiabetic rats , *increased* plasma [insulin] ( P =.016 ) and prevented the fasting induced decrease of circulating leptin ( P =.004 ) over the initial 12 hours compared with vehicle . Positive_regulation INS TNF 12475383 1023615 SOCS ( suppressor of cytokine signaling ) -3 has recently been shown to be an insulin- and *induced* negative regulator of [insulin] signaling . Positive_regulation INS TNF 14764603 1235133 In this study we demonstrate that pretreatment with PD169316 or SB203580 , inhibitors of p38 MAPK , restored [insulin] signaling and normalized insulin induced glucose uptake in the *presence* of . Positive_regulation INS TNF 14764603 1235134 Moreover , produced inhibitor kappaB kinase (IKK)-beta activation and inhibitor kappaB-beta and -alpha degradation in a p38 MAPK dependent manner , and treatment with salicylate ( an inhibitor of IKK ) completely *restored* [insulin] signaling . Positive_regulation INS TNF 15306563 1353540 *induced* [insulin] resistance in adipocytes as a membrane microdomain disorder : involvement of ganglioside GM3 . Positive_regulation INS TNF 15365619 1334205 Pretreatment with PD98059 or PD169316 , which inhibit p42/p44MAPK and p38MAPK respectively , restored [insulin] signalling and insulin induced glucose uptake in the *presence* of . Positive_regulation INS TNF 16080843 1442758 The synergistic effect of and leptin may *induce* [insulin] secretion , which in turn leads to insulin resistance . Positive_regulation INS TNF 16170397 1457161 Multiple regression analysis demonstrated the important *role* of in the regulation of both the insulin resistance and in the secretion of [insulin] in women . Positive_regulation INS TNF 16322532 1511623 Although insulin or alone did not affect arterial diameter , [insulin] *induced* dose dependent vasoconstriction of cremaster resistance arteries in the presence of TNF-alpha , ( -12+/-1 % at 272 microU/mL ) . Positive_regulation INS TNF 16539824 1537000 Since insulin resistance can promote endothelial dysfunction and anti-TNF-alpha blockade yield a rapid improvement of endothelial function , we have sought to assess whether blockade may also *result* in a reduction of [insulin] serum levels and improvement of insulin resistance in RA patients who require this therapy because of severe and refractory disease . Positive_regulation INS TNF 16644673 1553108 Here , we examined roles of mitochondrial ROS and ASK1 in *induced* impaired [insulin] signaling in cultured human hepatoma ( Huh7 ) cells . Positive_regulation INS TNF 16644673 1553124 These results suggest that increases mitochondrial ROS and activates ASK1 in Huh7 cells and that these TNF-alpha induced phenomena *contribute* , at least in part , to impaired [insulin] signaling . Positive_regulation INS TNF 18179781 1875779 Cyanidin 3-glucoside protects 3T3-L1 adipocytes against H2O2- or *induced* [insulin] resistance by inhibiting c-Jun NH2-terminal kinase activation . Positive_regulation INS TNF 18179781 1875780 Pretreatment of cells with Cy-3-G reduced the intracellular production of reactive oxygen species , the activation of JNK , and attenuated H ( 2 ) O ( 2 ) - or *induced* [insulin] resistance in a dose dependent manner . Positive_regulation INS TNF 18179781 1875781 Taken together , these results indicated that Cy-3-G exerts a protective role against H ( 2 ) O ( 2 ) - or *induced* [insulin] resistance in 3T3-L1 adipocytes by inhibiting the JNK signal pathway . Positive_regulation INS TNF 18385532 1907115 DHMEQ also partially ameliorated decreased cell viability and [insulin] mRNA level *induced* by . Positive_regulation INS TNF 1932101 169992 It is concluded that PAF and can *increase* hepatic lipogenesis in vivo in the absence of adrenal hormones and in the presence of a low plasma [insulin] . Positive_regulation INS TNF 20576518 2285475 Modulation of hypothalamic PTP1B in the *induced* [insulin] and leptin resistance . Positive_regulation INS TNF 21813649 2476918 Cyclin dependent kinase-5 is a key molecule in *induced* [insulin] resistance . Positive_regulation INS TNF 24323581 2899484 For example , *contributes* to the inability of cells to respond to insulin and to the increase in levels of [insulin] . Positive_regulation INS TNF 8130898 251424 Low-dose interleukin 1 and individually *stimulate* [insulin] release but in combination cause suppression . Positive_regulation INS TNF 8617880 353907 The different effects on FAK125 regulation allow the speculation that long-term cell effects related to FAK125 activity might develop in a different way in hyperglycemia- and *dependent* [insulin] resistance . Positive_regulation INS TNF 9545516 499269 Glycophosphatidyl inositol membrane anchors of parasite proteins possess [insulin] like activity and *induce* synthesis . Positive_regulation INS TUB 22966070 2716057 These results indicate that Tub has a key role in the control of insulin and leptin effects on food intake , and the modulation of may *contribute* to [insulin] and leptin resistance in DIO mice . Positive_regulation INSIG1 EPHB2 15731359 1403000 We report that : 1 ) insulin induced transcription of ATF-3 , Pip92 , and [Insig-1] *required* activation ; Positive_regulation INSIG1 MAP2K6 15731359 1403007 We report that : 1 ) insulin induced transcription of ATF-3 , Pip92 , and [Insig-1] *required* activation ; Positive_regulation INSR EPHB2 18079194 1868210 Augmentation of basal IGF-I receptor phosphorylation was associated with coordinate increases in basal tyrosine phosphorylation of [insulin receptor substrate (IRS)-2] and *activation* of , which were also minimally responsive to IGF-I stimulation . Positive_regulation INSR TNF 16644673 1553116 significantly activated ASK1 , *increased* serine phosphorylation of [insulin receptor substrate (IRS)-1] , and decreased insulin stimulated tyrosine phosphorylation of IRS-1 and serine phosphorylation of Akt , and all of these effects were inhibited by overexpression of either UCP-1 or MnSOD . Positive_regulation INSR TNF 17227768 1703821 We tested whether mitogenic activated protein kinase kinase kinase kinase isoform 4 ( MAP4K4 ) causes the *induced* negative regulation of extracellular signal regulated kinase-1/2 ( ERK-1/2 ) , c-Jun NH2-terminal kinase (JNK) , and the [insulin receptor substrate-1 (IRS-1)] on the insulin signaling pathway governing glucose metabolism . Positive_regulation INSR TNF 24648009 2934637 This event is thought to be mediated via interference of *induced* interaction of ß1-integrin with [insulin receptor substrate-1 (IRS-1)] . Positive_regulation INSR TNF 7559552 323941 alpha *induced* phosphorylation of [insulin receptor substrate-1 (IRS-1)] . Positive_regulation INTS3 TNF 2229314 144599 Compared with the control experiment , *induced* significant decreases [in T3] ( -36 +/- 2 % ; saline , -20 +/- 3 % ; Positive_regulation IQGAP1 ANGPT1 21885850 2496453 Further , our data show that *requires* [IQGAP1] as an indispensable activator of Rac1 . Positive_regulation IRAK1 IL1B 11257459 794481 However , *induced* [IRAK] activation was not affected by PD153035 . Positive_regulation IRAK1 IL1B 11698503 878210 However , neither TNF-alpha nor *induced* [IRAK] degradation or stimulated TNF-alpha or TxB2 production in naive cells . Positive_regulation IRAK1 IL1B 17668873 1816288 These age related changes in JNK phosphorylation correlated with diminished *induced* degradation of [interleukin-1 receptor associated kinase-1] ( IRAK-1 ) . Positive_regulation IRAK1 IL1B 19342688 2056861 By small interfering RNAs mediated knockdown , we show that induced up-regulation of ADAMTS-4 in chondrocytes *requires* MyD88 , [IRAK1] , and TRAF6 adaptor proteins . Positive_regulation IRAK1 TLR7 12616494 1065667 PP2 , an inhibitor of Src family tyrosine kinases , prevented the TLR induced phosphorylation of paxillin and Pyk2 without affecting *induced* [IRAK] activation . Positive_regulation IRAK1 TLR7 18079163 1874565 Stimulation of these cells with ligands did not *cause* the degradation of [IRAK-1] , which was clearly observed in the parent cells . Positive_regulation IRAK1 TLR7 19166926 2038467 Phosphorylation of [IRAK-1] by IRAK-4 in *response* to activation may then release IRAK-1 from the inhibitory constraint exerted by its C-terminal domain . Positive_regulation IRAK1 TNF 11698503 878209 However , neither nor IL-1beta *induced* [IRAK] degradation or stimulated TNF-alpha or TxB2 production in naive cells . Positive_regulation IRAK2 IL1B 11257459 794482 However , induced [IRAK] *activation* was not affected by PD153035 . Positive_regulation IRAK2 IL1B 11698503 878212 However , neither TNF-alpha nor *induced* [IRAK] degradation or stimulated TNF-alpha or TxB2 production in naive cells . Positive_regulation IRAK2 IL1B 17668873 1816289 These age related changes in JNK phosphorylation correlated with diminished *induced* degradation of [interleukin-1 receptor associated kinase-1] ( IRAK-1 ) . Positive_regulation IRAK2 TLR7 12616494 1065677 PP2 , an inhibitor of Src family tyrosine kinases , prevented the TLR induced phosphorylation of paxillin and Pyk2 without affecting *induced* [IRAK] activation . Positive_regulation IRAK2 TLR7 19913487 2166483 Both proteins interact with [IRAK2] and TRAF6 and suppress dependent NF-kappaB *activation* . Positive_regulation IRAK2 TLR7 21606490 2450228 Collectively , these data demonstrate for the first time an essential *role* for [IRAK-2] in primary human cells for both transcriptional and post-transcriptional responses . Positive_regulation IRAK2 TNF 11698503 878211 However , neither nor IL-1beta *induced* [IRAK] degradation or stimulated TNF-alpha or TxB2 production in naive cells . Positive_regulation IRAK3 IL1B 11257459 794479 However , *induced* [IRAK] activation was not affected by PD153035 . Positive_regulation IRAK3 IL1B 11698503 878202 However , neither TNF-alpha nor *induced* [IRAK] degradation or stimulated TNF-alpha or TxB2 production in naive cells . Positive_regulation IRAK3 IL1B 17668873 1816286 These age related changes in JNK phosphorylation correlated with diminished *induced* degradation of [interleukin-1 receptor associated kinase-1] ( IRAK-1 ) . Positive_regulation IRAK3 TLR7 12616494 1065647 PP2 , an inhibitor of Src family tyrosine kinases , prevented the TLR induced phosphorylation of paxillin and Pyk2 without affecting induced [IRAK] *activation* . Positive_regulation IRAK3 TLR7 20817880 2325112 We found that [IRAK-M] is *induced* in DCs by ligation and that its absence from these cells leads to increased activation of the p38-MAPK and NF-?B pathways , which , in turn , improves DC migration to lymph nodes , increases their longevity , and augments their secretion of Th1 skewing cytokines and chemokines . Positive_regulation IRAK3 TLR7 21875872 2501131 These data identify a previously unknown function of IRAK-M-namely , suppression of *mediated* autoimmunity-and mutant [IRAK-M] as a previously unknown genetic risk for murine SLE . Positive_regulation IRAK3 TNF 11698503 878201 However , neither nor IL-1beta *induced* [IRAK] degradation or stimulated TNF-alpha or TxB2 production in naive cells . Positive_regulation IRAK3 TNF 15275867 1276742 It is known that NO induces the expression of TNF-alpha in monocytes and we found that exposure to *induced* [IRAK-M] mRNA expression in human monocytes within 2 h of stimulation . Positive_regulation IRAK3 TNF 21098228 2372039 Without CASP-6 expression , PMN stimulation fails to cleave [IRAK-M] , degrade I?Ba , or *induce* . Positive_regulation IRAK4 IL1B 10076187 597386 The addition of TGFbeta1 also suppressed the steady-state levels of *stimulated* IL-1beta , type I [IL-1 receptor] and IL-1 receptor antagonist transcripts ( 98 , 67 and 83 % inhibition respectively ) . Positive_regulation IRAK4 IL1B 11257459 794480 However , induced [IRAK] *activation* was not affected by PD153035 . Positive_regulation IRAK4 IL1B 11698503 878204 However , neither TNF-alpha nor *induced* [IRAK] degradation or stimulated TNF-alpha or TxB2 production in naive cells . Positive_regulation IRAK4 IL1B 14622206 1168653 *Stimulation* of [IL-1 receptor] by may induce the phosphorylation of tyrosine residues in many effector proteins through the activation of p60c-src kinase . Positive_regulation IRAK4 IL1B 17668873 1816287 These age related changes in JNK phosphorylation correlated with diminished *induced* degradation of [interleukin-1 receptor associated kinase-1] ( IRAK-1 ) . Positive_regulation IRAK4 IL1B 20680966 2311869 OSM increased type 1 [IL-1 receptor] ( IL-1R1 ) expression , and *enhanced* OSMRbeta expression on HGFs . Positive_regulation IRAK4 IL1B 8536851 346145 ( 50 % effective concentration [ EC50 ] , 5.3 +/- 0.4 ng/mL ) and tumor necrosis factor (TNF) alpha ( EC50 , 5.5 +/- 0.5 ng/mL ) *stimulated* gastrin release to 50 % of the maximal response to 10 ( -9 ) mol/L neuromedin C. Stimulation by the maximally effective concentration of IL-1 beta ( 10 ng/mL ) was inhibited by the human [IL-1 receptor] antagonist ( 100 ng/mL ; inhibitory constant , 23.0 ng/mL ) , which prefers type I over type II IL-1 receptors . Positive_regulation IRAK4 TLR7 12616494 1065657 PP2 , an inhibitor of Src family tyrosine kinases , prevented the TLR induced phosphorylation of paxillin and Pyk2 without affecting *induced* [IRAK] activation . Positive_regulation IRAK4 TNF 10643716 660981 In *response* to stimulation , messenger RNA ( mRNA ) levels for the [IL-1 receptor I (IL-1RI)] , IL-1RII , TNF receptor II (TNFR II) , and IL-6 receptor as well as the level of proinflammatory cytokines , such as IL-1alpha , IL-1beta , lymphotoxin beta , TNFalpha , and IL-6 , also increased . Positive_regulation IRAK4 TNF 11698503 878203 However , neither nor IL-1beta *induced* [IRAK] degradation or stimulated TNF-alpha or TxB2 production in naive cells . Positive_regulation IRF1 EPHB2 15063806 1231055 The use of inhibitors selective for ERK ( PD98059 ) and p38 ( SB203580 ) mitogen activated protein (MAP) kinase pathway showed that preincubation of cells with either SB203580 or PD98059 did not affect the binding activity of IRF-E , suggesting that both p38 and MAP kinase activation are not *necessary* for [IRF-E] activation . Positive_regulation IRF1 FAS 11801659 902585 Ectopic [IRF-1] expression *induces* promoter activity . Positive_regulation IRF1 IL1B 11742807 897780 Conversely , IFN-gamma , but not , *induced* signal transducer and activator of transcription ( STAT ) 1 and [interferon regulatory factor (IRF)-1] binding . Positive_regulation IRF1 IL1B 16140971 1451008 We found that *regulated* [IRF-1] gene expression through stimulation of p38 mitogen activated protein kinase (MAPK) , which mediated signal transducer and activator of transcription 1 ( Stat1 ) serine phosphorylation and Stat1 nuclear translocation to activate the IRF-1 promoter . Positive_regulation IRF1 IL1B 19843519 2170099 Histone deacetylase-1 is enriched at the platelet derived growth factor-D promoter in *response* to and forms a cytokine-inducible gene silencing complex with NF-kappab p65 and [interferon regulatory factor-1] . Positive_regulation IRF1 IL1B 19843519 2170106 [Interferon regulatory factor-1 (IRF-1)] is also *induced* by and binds to a different element upstream in the promoter . Positive_regulation IRF1 IL1B 19843519 2170109 Immunoprecipitation and chromatin immunoprecipitation experiments showed that *stimulates* p65 interaction with [IRF-1] and the accumulation of both factors at the PDGF-D promoter . Positive_regulation IRF1 IL1B 9202213 439970 alone *induced* a marginal and transient increase in [IRF-1] . Positive_regulation IRF1 IL1B 9202213 439971 It has been previously reported that nicotinamide prevents *induced* [IRF-1] expression in rat pancreatic islets . Positive_regulation IRF1 IL1B 9973374 596008 We now report that levels of [IRF-1] and pIgR mRNA are coordinately *regulated* in HT-29 cells by TNF-alpha , IFN-gamma , and . Positive_regulation IRF1 MAP2K6 17274000 1697264 Inhibitors of PI3 K , p38 MAPK , and *suppressed* IL-18 plus IFN-gamma induced CXCL9 , CXCL10 , and CXCL11 production and NF-kappaB , STAT1 , and [IRF-1] activities . Positive_regulation IRF1 TLR7 18401006 1925735 Adenylate cycalse toxin of Bordetella pertussis inhibits *induced* [IRF-1] and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells . Positive_regulation IRF1 TLR7 20829348 2342053 Overexpression of hCactin suppresses *induced* activation of NF-?B and [interferon-regulatory factor] transcription factors and induction of TLR-responsive genes , whereas knockdown of endogenous hCactin augments TLR induction of these responses . Positive_regulation IRF1 TNF 10363677 620193 stimulation *enhanced* [IRF-1] mRNA levels in infected cells and was required to detect IRF-1 protein by immunoblotting . Positive_regulation IRF1 TNF 10404391 629260 *Induction* of transcription factor [interferon regulatory factor-1] by interferon-gamma (IFN gamma) and in FRTL-5 cells . Positive_regulation IRF1 TNF 11319155 806774 Furthermore , IFNgamma and TNFalpha treatment elevated levels of IRF-1 within 2 h. *induced* increases in the levels of [IRF-1] were transient , whereas the levels of IRF-1 in response to IFNgamma treatment remained elevated at 48 h . Positive_regulation IRF1 TNF 12115600 964181 Hyperosmotic medium also inhibited the expression of [IRF-1] *induced* by or IFN-gamma . Positive_regulation IRF1 TNF 14519761 1174277 In this study , in a time dependent manner activated both janus tyrosine kinase 1 and Tyk2 tyrosine kinase and *increased* the nuclear translocation of [interferon-regulatory factor-1] , STAT1 , and STAT2 in human airway smooth muscle cells . Positive_regulation IRF1 TNF 14708625 1181173 *Induction* of [interferon regulatory factor 1] expression in human dermal endothelial cells by interferon-gamma and is transcriptionally regulated and requires iron . Positive_regulation IRF1 TNF 15265939 1275744 and 4 ) reduces *induced* [IRF-1] expression in HAEC . Positive_regulation IRF1 TNF 16228299 1476729 Interestingly , *induced* [interferon regulatory factor (IRF)-1] activation was significantly inhibited by all calcium mobilizing agents , BK , Thr and Tg . Positive_regulation IRF1 TNF 16861340 1588893 Thus , knock-down of RAX expression by 80 % using small interfering RNA ( siRNA ) prevents *induced* PKR activation and eIF2alpha phosphorylation , IkappaB degradation , [IRF-1] expression , and STAT1 phosphorylation , resulting in enhanced murine embryonic fibroblast (MEF) cell survival . Positive_regulation IRF1 TNF 16978650 1633548 Peptide YY reverses *induced* transcription factor binding of [interferon regulatory factor-1] and p53 in pancreatic acinar cells . Positive_regulation IRF1 TNF 16978650 1633555 We hypothesized that would *induce* [IRF-1] and p53 protein binding in pancreatic acinar cells and that PYY would attenuate the effect . Positive_regulation IRF1 TNF 17947510 1882593 Interestingly , the capacity of fluticasone to completely inhibit *induced* IRF-1 expression , [IRF-1] DNA binding , and transactivation activities was completely lost in cells exposed to TNF-alpha and IFN-gamma in combination . Positive_regulation IRF1 TNF 18678606 1973299 Instead , and PGE2 increased Stat1 serine phosphorylation and Stat4 tyrosine phosphorylation and *activated* expression of the NF-kappaB and Stat1 target gene [IFN regulatory factor 1 (IRF1)] , which contributes to IFN responses . Positive_regulation IRF1 TNF 19627149 2180267 Moreover , pretreatment with a Jak/STAT inhibitor decreased *induced* VCAM-1 expression and nuclear GATA-4 , GATA-6 , and [IRF-1] levels . Positive_regulation IRF1 TNF 20861350 2331701 Interestingly , LPA inhibited IFN-? and *induced* [IRF-1] activation by blocking the binding of IRF-1 to its DNA consensus sequence without changing IRF-1 induction and its nuclear translocation . Positive_regulation IRF1 TNF 24516119 2924106 Increased ERK1/2 activity antagonizes VCAM-1 expression by repressing *induction* of the transcription factor [IRF-1] . Positive_regulation IRF1 TNF 24657155 2938535 We also found that GA is able to attenuate the upregulation of [IRF-1] *induced* by . Positive_regulation IRF1 TNF 8746784 343507 We demonstrated here that induced binding of NF kappa B p50 and p65 to the NF kappa B-like element of the MHC class I promoter termed region I and IFN-gamma *induced* binding of [IRF-1] to the adjacent interferon consensus sequence ( ICS ) . Positive_regulation IRF1 TNF 9973374 596004 We previously reported that IFN-gamma and *induce* production of the transcription factor [IFN regulatory factor-1 (IRF-1)] in HT-29 cells and that IRF-1 binds to an element in exon 1 of the PIGR gene . Positive_regulation IRF1 TNF 9973374 596006 We now report that levels of [IRF-1] and pIgR mRNA are coordinately *regulated* in HT-29 cells by , IFN-gamma , and IL-1beta . Positive_regulation IRF1 TNFSF10 15241475 1274126 Our results identify a novel *mediated* tumor suppressor activity of [IRF-1] and suggest a mechanistic basis for the synergistic antitumor activities of certain retinoids and interferons . Positive_regulation IRF2 EPHB2 15063806 1231057 The use of inhibitors selective for ERK ( PD98059 ) and p38 ( SB203580 ) mitogen activated protein (MAP) kinase pathway showed that preincubation of cells with either SB203580 or PD98059 did not affect the binding activity of IRF-E , suggesting that both p38 and MAP kinase activation are not *necessary* for [IRF-E] activation . Positive_regulation IRF2 TLR7 20829348 2342063 Overexpression of hCactin suppresses induced *activation* of NF-?B and [interferon-regulatory factor] transcription factors and induction of TLR-responsive genes , whereas knockdown of endogenous hCactin augments TLR induction of these responses . Positive_regulation IRF3 EPHB2 15063806 1231059 The use of inhibitors selective for ERK ( PD98059 ) and p38 ( SB203580 ) mitogen activated protein (MAP) kinase pathway showed that preincubation of cells with either SB203580 or PD98059 did not affect the binding activity of IRF-E , suggesting that both p38 and MAP kinase activation are not *necessary* for [IRF-E] activation . Positive_regulation IRF3 FOXO1 23532851 2777562 interacted with IRF3 in a viral infection dependent manner and *promoted* K48 linked polyubiquitination and degradation of [IRF3] in the cytosol . Positive_regulation IRF3 FOXO1 23532851 2777563 Furthermore , *mediated* degradation of [IRF3] was independent of the known E3 ubiquitin ligases for IRF3 , including RBCK1 and RAUL . Positive_regulation IRF3 IL1B 15749911 1379793 We also show that *induces* phosphorylation and nuclear translocation of [IRF3] and delayed phosphorylation of STAT1 . Positive_regulation IRF3 ITGB2 23209319 2718411 First , facilitated poly I:C internalization through the activation of PI3K signaling and *enhanced* TLR3 dependent activation of [IRF3] in macrophages . Positive_regulation IRF3 TLR7 14555995 1158580 Transcription factor [IRF-3] is post-translationally *activated* by signaling and has critical roles in the regulation of innate immunity . Positive_regulation IRF3 TLR7 19005481 2041451 IL-10 was found to downregulate MyD88 , IRAK1 ( IL-1 receptor associated kinase ) and tumor necrosis factor receptor associated factor 6 , essential adaptor molecules for TLR signaling , and to decrease *induced* nuclear expression of the nuclear factor-kappaB transcription factors c-Rel and Rel-B as well as [interferon regulatory factor (IRF)-3] and IRF-8 . Positive_regulation IRF3 TLR7 20351107 2260698 In this study , we show that c-Src has distinct roles in mediated *activation* of IRF-5 and [IRF-3] . Positive_regulation IRF3 TLR7 20829348 2342073 Overexpression of hCactin suppresses induced *activation* of NF-?B and [interferon-regulatory factor] transcription factors and induction of TLR-responsive genes , whereas knockdown of endogenous hCactin augments TLR induction of these responses . Positive_regulation IRF3 TLR7 22473004 2589077 NLRC5 ablation reduces MHC class I expression , and enhances IKK and [IRF3] phosphorylation in *response* to stimulation or viral infection . Positive_regulation IRF3 TLR7 24244017 2879596 Its functions are controversial , with in vitro studies finding that optineurin suppressed TNF mediated NF-?B activation and virus induced activation of IFN regulatory factor 3 (IRF3) , whereas bone marrow derived macrophages ( BMDMs ) from mice carrying an optineurin Ub-binding point mutation had normal mediated NF-?B activation and diminished [IRF3] *activation* . Positive_regulation IRF3 TNF 12388374 1012756 stimulation *induces* nuclear translocation of [interferon regulatory factor (IRF)-3] , which in viral infection binds the RANTES ISRE and is necessary for activation of RANTES transcription . Positive_regulation IRF3 TNF 12388374 1012757 However , *induced* [IRF-3] translocation does not result in IRF-3 binding to the RANTES ISRE . Positive_regulation IRF3 TNF 17328045 1711881 Poly ( I-C ) , lipopolysaccharide , and *activated* phosphorylation of IKKepsilon and [IRF-3] in FLS . Positive_regulation IRF3 TNF 24244017 2879595 Its functions are controversial , with in vitro studies finding that optineurin suppressed mediated NF-?B activation and virus induced *activation* of [IFN regulatory factor 3 (IRF3)] , whereas bone marrow derived macrophages ( BMDMs ) from mice carrying an optineurin Ub-binding point mutation had normal TLR mediated NF-?B activation and diminished IRF3 activation . Positive_regulation IRF4 EPHB2 15063806 1231061 The use of inhibitors selective for ERK ( PD98059 ) and p38 ( SB203580 ) mitogen activated protein (MAP) kinase pathway showed that preincubation of cells with either SB203580 or PD98059 did not affect the binding activity of IRF-E , suggesting that both p38 and MAP kinase activation are not *necessary* for [IRF-E] activation . Positive_regulation IRF4 TLR7 16243976 1476854 Here , we demonstrate that [IRF-4] negatively regulates the production of proinflammatory cytokines by macrophages in *response* to stimulation . Positive_regulation IRF4 TLR7 20829348 2342083 Overexpression of hCactin suppresses *induced* activation of NF-?B and [interferon-regulatory factor] transcription factors and induction of TLR-responsive genes , whereas knockdown of endogenous hCactin augments TLR induction of these responses . Positive_regulation IRF5 EPHB2 15063806 1231063 The use of inhibitors selective for ERK ( PD98059 ) and p38 ( SB203580 ) mitogen activated protein (MAP) kinase pathway showed that preincubation of cells with either SB203580 or PD98059 did not affect the binding activity of IRF-E , suggesting that both p38 and MAP kinase activation are not *necessary* for [IRF-E] activation . Positive_regulation IRF5 TLR7 15695821 1395586 Here we show that in contrast to IRF3 and IRF7 , [IRF5] is not a target of the TLR3 signaling pathway but is *activated* by or TLR8 signaling . Positive_regulation IRF5 TLR7 18824541 1987877 [IRF-5] is *activated* by and TLR9 via the MyD88 pathway , where it interacts with both MyD88 and the E3 ubiquitin ligase , TRAF6 . Positive_regulation IRF5 TLR7 20351107 2260708 In this study , we show that c-Src has distinct roles in *mediated* activation of [IRF-5] and IRF-3 . Positive_regulation IRF5 TLR7 20829348 2342093 Overexpression of hCactin suppresses *induced* activation of NF-?B and [interferon-regulatory factor] transcription factors and induction of TLR-responsive genes , whereas knockdown of endogenous hCactin augments TLR induction of these responses . Positive_regulation IRF5 TLR7 21253574 2380244 We show that *mediated* activation of [IRF-5] is essential for the development of Th1 responses to L. donovani in the spleen during chronic infection . Positive_regulation IRF5 TLR7 22535200 2637433 [IRF-5] is a transcription factor *activated* by and TLR9 during innate immune responses . Positive_regulation IRF5 TLR7 23154183 2723123 We show here that the Il12b enhancer contains functional ISREs for recognition by interferon regulatory factors ( IRFs ) , and provide evidence that *activated* [IRF5] mediates cooperativity of the enhancer with the promoter which also contains ISREs . Positive_regulation IRF5 TNF 15695821 1395588 We also demonstrate that MyD88 , interleukin 1 receptor associated kinase 1 , and receptor associated factor 6 are *required* for the activation of [IRF5] and IRF7 in the TLR7 signaling pathway . Positive_regulation IRF5 TNFSF10 19028697 2022888 The results presented here identify IRF-5 as a new mediator of DR signaling and provides molecular insight into the mechanism of *induced* [IRF-5] signaling . Positive_regulation IRF6 EPHB2 15063806 1231065 The use of inhibitors selective for ERK ( PD98059 ) and p38 ( SB203580 ) mitogen activated protein (MAP) kinase pathway showed that preincubation of cells with either SB203580 or PD98059 did not affect the binding activity of IRF-E , suggesting that both p38 and MAP kinase activation are not *necessary* for [IRF-E] activation . Positive_regulation IRF6 TLR7 20829348 2342103 Overexpression of hCactin suppresses *induced* activation of NF-?B and [interferon-regulatory factor] transcription factors and induction of TLR-responsive genes , whereas knockdown of endogenous hCactin augments TLR induction of these responses . Positive_regulation IRF7 EPHB2 15063806 1231067 The use of inhibitors selective for ERK ( PD98059 ) and p38 ( SB203580 ) mitogen activated protein (MAP) kinase pathway showed that preincubation of cells with either SB203580 or PD98059 did not affect the binding activity of IRF-E , suggesting that both p38 and MAP kinase activation are not *necessary* for [IRF-E] activation . Positive_regulation IRF7 IL1B 15749911 1379791 We now show , using real-time PCR , that in astrocytes *induces* the expression of IFN-beta , [IRF7] , CXCL10/IFN-gamma-inducible protein-10 , and CCL5/RANTES . Positive_regulation IRF7 TLR7 20829348 2342113 Overexpression of hCactin suppresses induced *activation* of NF-?B and [interferon-regulatory factor] transcription factors and induction of TLR-responsive genes , whereas knockdown of endogenous hCactin augments TLR induction of these responses . Positive_regulation IRF7 TLR7 21435390 2438426 These data provide evidence that cigarette smoke suppresses key pDC functions upon viral infection by a mechanism that involves downregulation of expression and decreased *activation* of [IRF-7] . Positive_regulation IRF7 TNF 11877397 937090 Using promoter analysis in combination with electrophoretic mobility shift assays , we have demonstrated that an NFkappaB site located next to the TATA box , binds p50 and p65 heterodimer and is required for the *induction* of the [IRF-7] gene by TPA and . Positive_regulation IRF7 TNF 15256426 1322060 Although [IRF-7] was *up-regulated* by and RA in all cells tested , expression of c-jun and PU.1 correlated with monocytic differentiation . Positive_regulation IRF7 TNF 15695821 1395594 We also demonstrate that MyD88 , interleukin 1 receptor associated kinase 1 , and receptor associated factor 6 are *required* for the activation of IRF5 and [IRF7] in the TLR7 signaling pathway . Positive_regulation IRF7 TNF 16537619 1536819 IFN-alpha and *induced* the expression of the RIG-I , TLR3 , MyD88 , TRIF , and [IRF7] genes , whereas no detectable TLR7 and TLR8 was seen in A549 cells . Positive_regulation IRF8 CAPN8 15837792 1418051 IRF-8 induced in peritoneal macrophages by interferon-gamma and lipopolysaccharide was degraded rapidly , and degradation of [IRF-8] was *blocked* by MG132 , the proteasome inhibitor , but inhibitors of and lysosomal enzymes had no effect . Positive_regulation IRF8 EPHB2 15063806 1231053 The use of inhibitors selective for ERK ( PD98059 ) and p38 ( SB203580 ) mitogen activated protein (MAP) kinase pathway showed that preincubation of cells with either SB203580 or PD98059 did not affect the binding activity of IRF-E , suggesting that both p38 and MAP kinase activation are not *necessary* for [IRF-E] activation . Positive_regulation IRF8 FAS 21487040 2417732 Consequently , restoration of [IRF8] expression suppressed CML development in vivo at least partially through a *dependent* mechanism . Positive_regulation IRF8 TLR7 18401006 1925725 Adenylate cycalse toxin of Bordetella pertussis inhibits *induced* IRF-1 and [IRF-8] activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells . Positive_regulation IRF8 TLR7 19005481 2041441 IL-10 was found to downregulate MyD88 , IRAK1 ( IL-1 receptor associated kinase ) and tumor necrosis factor receptor associated factor 6 , essential adaptor molecules for TLR signaling , and to decrease *induced* nuclear expression of the nuclear factor-kappaB transcription factors c-Rel and Rel-B as well as interferon regulatory factor (IRF)-3 and [IRF-8] . Positive_regulation IRF8 TLR7 20829348 2342043 Overexpression of hCactin suppresses *induced* activation of NF-?B and [interferon-regulatory factor] transcription factors and induction of TLR-responsive genes , whereas knockdown of endogenous hCactin augments TLR induction of these responses . Positive_regulation IRF9 EPHB2 15063806 1231069 The use of inhibitors selective for ERK ( PD98059 ) and p38 ( SB203580 ) mitogen activated protein (MAP) kinase pathway showed that preincubation of cells with either SB203580 or PD98059 did not affect the binding activity of IRF-E , suggesting that both p38 and MAP kinase activation are not *necessary* for [IRF-E] activation . Positive_regulation IRF9 TLR7 20829348 2342123 Overexpression of hCactin suppresses induced *activation* of NF-?B and [interferon-regulatory factor] transcription factors and induction of TLR-responsive genes , whereas knockdown of endogenous hCactin augments TLR induction of these responses . Positive_regulation IRF9 TNFSF10 19752753 2168281 In IFN-alpha treated OVCAR3 cells , IRF9-RNAi inhibited transcription of TRAIL whereas Stat1-RNAi did not , suggesting that the transcription of induced by IFN-alpha predominantly *required* [IRF9] . Positive_regulation IRG1 CAPN8 22580607 2757117 Spheroidgenesis and lymphovascular emboli formation are the direct result of *mediated* cleavage of E-cad and the generation of [E-cad/NTF1] from membrane associated E-cad rather than the de novo presence of either E-cad/NTF1 or E-cad/CTF1 . Positive_regulation IRG1 MAP2K6 21557297 2464070 Pharmacologic inhibition of EGFR , , and PI3K kinase activity in SCC10A *reduced* phosphorylated levels of ERK-1/2 and AKT , production of MMP-9 and [sE-cad] , cell migration and invasion , and expressional changes of EMT markers ( E-cadherin and N-cadherin ) induced by EGF , indicating that EGFR activation promotes cell migration and invasion via ERK-1/2 and PI3K regulated MMP-9/E-cadherin signaling pathways . Positive_regulation IRS1 CCND1 17332342 1707482 The increased transformed phenotype is characterized by occupancy of the rDNA and cyclin D1 promoters by [IRS-1] and the *activation* of the , c-myc , and rDNA promoters . Positive_regulation IRS1 CCND1 17700539 1848733 Transcriptional *activation* of c-myc and promoters by nuclear [IRS-1] does not occur with a mutant , inactive IRS-1 protein ( deletion of the phosphotyrosine binding domain , PTB ) and does not require PI3-kinase activity . Positive_regulation IRS1 EPHB2 19834495 2216953 Increased Akt activity in p110 beta-deficient myoblasts was associated with diminished extracellular signal regulated kinase ( ERK ) activation as well as *dependent* [IRS-1] 636/639 phosphorylation , findings we show to be independent of p110 beta catalytic function , but associated with insulin-like growth factor-I receptor ( IGF-IR ) endocytosis . Positive_regulation IRS1 MAP2K6 10847581 700869 PI 3-kinase inhibitors or rapamycin , but not the inhibitor , *blocked* both the insulin induced electrophoretic mobility shift and degradation of [IRS-1] . Positive_regulation IRS1 MAP2K6 21119656 2372366 Importantly , inhibition of and mTOR *resulted* in increased levels of pAKT and [IRS-1] , and a-TEA blocked them . Positive_regulation IRS1 TNF 11043572 742363 However , little is known about which signaling molecules are involved in this process in adipocytes and about the temporal sequence of events that ultimately leads to *stimulated* [IRS-1] serine phosphorylation . Positive_regulation IRS1 TNF 11043572 742364 Additional experiments show that MEK1/2 activity is required for *induced* [IRS-1] serine phosphorylation , thereby suggesting a mechanism by which these inhibitors restore insulin signaling . Positive_regulation IRS1 TNF 11160134 781475 Insulin/IGF-1 and *stimulate* phosphorylation of [IRS-1] at inhibitory Ser307 via distinct pathways . Positive_regulation IRS1 TNF 11160134 781480 This antibody revealed that , IGF-1 , or insulin *stimulated* phosphorylation of [IRS-1] at Ser307 in 3T3-L1 preadipocytes and adipocytes . Positive_regulation IRS1 TNF 11707432 903901 Pharmacological depletion of GM3 in adipocytes by an inhibitor of glucosylceramide synthase prevented the TNF-alpha induced defect in insulin dependent tyrosine phosphorylation of IRS-1 and also counteracted the *induced* serine phosphorylation of [IRS-1] . Positive_regulation IRS1 TNF 11717189 881904 Moreover , *had* no effect on the activation of [IRS-1] induced by IL-4 . Positive_regulation IRS1 TNF 12351658 1018869 In this study , using phosphospecific antibodies against rat IRS-1 phosphorylated at Ser ( 307 ) ( equivalent to Ser ( 312 ) in human IRS-1 ) , we observed serine phosphorylation of [IRS-1] in *response* to or calyculin A treatment that paralleled surrogate markers for IKK activation . Positive_regulation IRS1 TNF 12714600 1100545 Taken together , these data suggest that serine phosphorylation of [IRS-1] in *response* to is mediated , in part , by JNK and IKK . Positive_regulation IRS1 TNF 12887130 1116901 *had* no effect on either [IRS-1] phosphorylation or ERK in VSMC . Positive_regulation IRS1 TNF 15181014 1280564 The ameliorated insulin signaling in SOCS3-deficient adipocytes is mainly due to the suppression of *induced* [IRS1] and IRS2 protein degradation . Positive_regulation IRS1 TNF 16267124 1502066 Furthermore , both fasudil and Y-27632 prevented the serine phosphorylation of [IRS-1] *induced* by insulin and/or in skeletal muscle cells . Positive_regulation IRS1 TNF 16754954 1571566 Myosin motor Myo1c and its receptor NEMO/IKK-gamma promote *induced* serine307 phosphorylation of [IRS-1] . Positive_regulation IRS1 TNF 16754954 1571573 NEMO expression also enhanced *induced* [Ser307-IRS-1] phosphorylation and inhibited glucose uptake . Positive_regulation IRS1 TNF 16777978 1599350 Consistent with these results , *induces* JNK binding to [insulin receptor substrate 1 (IRS-1)] but is unable to inhibit IGF-I induced IRS-1 tyrosine phosphorylation in myoblasts that are treated with the JNK peptide inhibitor . Positive_regulation IRS1 TNF 17379643 1741523 transiently *stimulated* serine phosphorylation of [IRS-1] from 10 min to 1 h , whereas insulin stimulated IRS-1 tyrosine phosphorylation was inhibited only after TNFalpha treatment longer than 4 h . Positive_regulation IRS1 TNF 17379643 1741525 Interestingly , when [IRS-1] serine phosphorylation was *enhanced* by or anisomycin in the presence of low-level SOCS3 , IRS-1 degradation was remarkably enhanced . Positive_regulation IRS1 TNF 17446186 1749505 increased p38 MAPK phosphorylation , potently *stimulated* [IRS-1] serine phosphorylation , and blunted insulin stimulated IRS-1 tyrosine and Akt phosphorylation and eNOS activity . Positive_regulation IRS1 TNF 17481767 1778114 Here we demonstrate that increases mitochondrial ROS production and ASK1 activity , and that these TNF-alpha induced phenomena associate with JNK activation , *increase* in Ser ( 307 ) phosphorylation of [IRS-1] and decrease in insulin stimulated tyrosine phosphorylation of IRS-1 , all of which are believed to be the molecular basis of TNF-alpha induced insulin resistance . Positive_regulation IRS1 TNF 17593555 1774525 Because *triggers* phosphorylation of [insulin receptor substrate 1 (IRS-1)] on serine residues ( pS-IRS-1 ; Positive_regulation IRS1 TNF 17593555 1774527 IGF-I counteracts *mediated* accumulation of [pS-IRS-1-beta1-integrin] complexes supporting the stability of neuronal processes . Positive_regulation IRS1 TNF 18187553 1895248 Exogenous infusion *increased* c-Jun N-terminal kinase phosphorylation and [insulin receptor substrate-1] serine 307 phosphorylation , and inhibited insulin induced signaling in liver . Positive_regulation IRS1 TNF 18443205 1938521 Conversely , *induced* increases in [insulin receptor substrate-1] serine phosphorylation ( Ser ( 312 ) ) , Jun NH ( 2 ) -terminal kinase phosphorylation , and extracellular signal related kinase-1/2 mitogen activated protein kinase (MAPK) phosphorylation were unaltered by siRNA mediated IKKbeta reduction . Positive_regulation IRS1 TNF 18952604 2001053 Expression of a dominant negative S6K1 mutant prevented *induced* Ser-270 phosphorylation and [IRS-1] protein degradation . Positive_regulation IRS1 TNF 20219981 2243567 When cells were pretreated with exendin-4 , *induced* JNK and [IRS-1/2] serine phosphorylation was markedly reduced , Akt phosphorylation was increased , caspase-3 and Bcl-2 protein levels were restored to normal , and TNFalpha induced apoptosis was inhibited by 50 % . Positive_regulation IRS1 TNF 21386087 2411807 When cells were incubated with specific ErbB receptors antagonists or in cells lacking ErbB receptors , anisomycin- and *induced* [IRS-1] serine phosphorylation was attenuated , despite intact p38MAPK activation . Positive_regulation IRS1 TNF 23698110 2801435 Inhibition of the *induced* serine phosphorylation of [IRS-1] at 636/639 by AICAR . Positive_regulation IRS1 TNF 23698110 2801456 Here we investigated the role of AMPK in serine phosphorylation of [IRS-1] at 636/639 and 307 , which is *induced* by in 3T3L1 adipocytes . Positive_regulation IRS1 TNF 23698110 2801475 We demonstrated that the AMPK activator 5-aminoimidazole-4-carboxamide-1-d-ribofuranoside ( AICAR ) significantly inhibited the *induced* serine phosphorylation of [IRS-1] at 636/639 and 307 by suppression of extracellular signal regulated kinase ( ERK ) phosphorylation but not c-Jun-NH2-terminal kinase (JNK) phosphorylation . Positive_regulation IRS1 TNF 23698110 2801478 In conclusion , we propose a new mechanism in which AICAR suppresses *induced* serine phosphorylation of [IRS-1] at 636/639 and 307 by enhancing the interaction between ERK and DUSP9/MKP-4 . Positive_regulation IRS1 TNF 7559552 323946 In contrast , *increased* [IRS-1] phosphorylation on serine residues , leading to a decrease in its electrophoretic mobility . Positive_regulation IRS1 TNF 7559552 323949 Our data suggest that *induces* serine phosphorylation of [IRS-1] through inhibition of serine phosphatases or activation of serine kinases other than protein kinase C . Positive_regulation IRS1 TNF 8557661 347516 Human , which binds to the murine type 1 TNF receptor selectively , also *promotes* IRS-1 phosphorylation and binding of [IRS-1] to PI 3-kinase . Positive_regulation IRS2 EPHB2 19755487 2186638 IRS2 promoter activity rose even more after additional inhibition of p38MAPK indicating an inhibitory effect of p38MAPK on *mediated* [IRS2] transcription . Positive_regulation IRS2 FOXO1 17279346 1733258 Taken together , and SREBP-1c reciprocally *regulate* [IRS-2] expression and insulin sensitivity in the liver . Positive_regulation IRS2 FOXO1 20501674 2294833 We show that hepatic production *resulted* in significant induction of IR and [IRS2] expression . Positive_regulation IRS2 FOXO1 20685959 2322813 In contrast , PKR regulates [IRS2] , another major IRS family protein in the liver , at the transcriptional rather than the posttranslational level , and this effect is *mediated* by the transcription factor , , which has been previously shown to be regulated by insulin and plays a significant role in glucose homeostasis and energy metabolism . Positive_regulation IRS2 IL1B 20067833 2212262 These results indicated that glucose induced endogenous expression *increased* betaTC-6 cells apoptosis by inhibiting , at least in part , [IRS-2/Akt] mediated signalling through SOCS-1 upregulation . Positive_regulation IRS2 TNF 15181014 1280565 The ameliorated insulin signaling in SOCS3-deficient adipocytes is mainly due to the suppression of *induced* IRS1 and [IRS2] protein degradation . Positive_regulation IRS2 TNF 17940160 1888990 Conversely , Ser phosphorylation of [IRS-2] *mediated* by activation of mitogen activated protein kinase was the mechanism found in brown adipocytes . Positive_regulation IRS2 TNF 18629684 1936819 The mechanism found in brown adipocytes involves Ser phosphorylation of [IRS-2] *mediated* by activation of MAPKs . Positive_regulation IRS2 TNF 20219981 2243568 When cells were pretreated with exendin-4 , *induced* JNK and [IRS-1/2] serine phosphorylation was markedly reduced , Akt phosphorylation was increased , caspase-3 and Bcl-2 protein levels were restored to normal , and TNFalpha induced apoptosis was inhibited by 50 % . Positive_regulation IRS4 ASB4 21955513 2492633 The interaction of with IRS4 in cell lines *mediates* the degradation of [IRS4] and decreases insulin signaling . Positive_regulation IRS4 EGF 3048247 97187 [pp160] is not phosphorylated on tyrosine in *response* to platelet derived growth factor or . Positive_regulation IRS4 IGF1 12639902 1068748 In human skeletal muscle cells , both IRS-1 and IRS-2 are rapidly phosphorylated on tyrosine in response to insulin , whereas essentially no tyrosine phosphorylation of [IRS-4] was observed in *response* to both insulin and . Positive_regulation IRS4 IGF1R 11316748 806589 The *induced* interaction of [insulin receptor substrate-4] and Crk-II . Positive_regulation IRS4 IL4 7492780 332453 IL-13 and stimulation of murine L cell fibroblasts , which endogenously express the IL-4 receptor ( IL-4R alpha ) and lack expression of the IL-2 receptor gamma subunit ( IL-2R gamma ) , *resulted* in tyrosine phosphorylation of [insulin receptor substrate-1 (IRS-1)/4PS] . Positive_regulation IRS4 IL4 7492780 332455 Enhanced tyrosine phosphorylation of [IRS-1/4PS] was observed in *response* to , but not IL-13 treatment of L cells transfected with the IL-2R gamma chain . Positive_regulation IRS4 IL4 7492780 332459 These results indicate that IL-13 does not use the IL-2R gamma subunit in its receptor complex and that expression of IL-2R gamma enhances , but is not absolutely required for mediating *induced* tyrosine phosphorylation of [IRS-1/4PS] . Positive_regulation IRS4 INS 11912194 944610 The results from the overexpression of IRAS , where its amount was about the same as that of IRS-4 , indicated that IRAS associated directly with IRS-4 and showed that the increased complexation of IRS-4 with IRAS did not alter the *stimulated* tyrosine phosphorylation of IRS-4 or the association of [IRS-4] with phosphatidylinositol 3-kinase or Grb2 . Positive_regulation IRS4 INS 12639902 1068749 In human skeletal muscle cells , both IRS-1 and IRS-2 are rapidly phosphorylated on tyrosine in response to insulin , whereas essentially no tyrosine phosphorylation of [IRS-4] was observed in *response* to both and IGF-I . Positive_regulation IRS4 INS 1321133 190194 Zn2+ at 100 microM , Ni2+ at 1 mM , and Co2+ at 1 or 5 mM increased *dependent* phosphorylation of [pp160] at least 5-fold and autophosphorylation 2-fold . Positive_regulation IRS4 INS 1321133 190196 Vanadate ( 1 mM ) and molybdate ( 100 microM ) increased *dependent* phosphorylation of [pp160] by 3-fold when tested separately and 7-fold in combination . Positive_regulation IRS4 INS 1374400 186297 These results demonstrate that [pp160] is expressed in 3T3-L1 adipocytes during the time when insulin receptors are expressed in large numbers and that the maintenance of pp160 concentrations in adipocytes can be *regulated* by , Mix , and Dex . Positive_regulation IRS4 INS 16933034 1646434 Okadaic acid , the PP1A and PP2A Ser/Thr phosphatase inhibitor , increases [pp160] phosphorylation *induced* by and prevents the inhibitory effect of Ang II pre-stimulation . Positive_regulation IRS4 INS 20079766 2225641 The present data provide novel evidence of [IRS-4] phosphorylation *mediated* by , an effect modulated by Ang II . Positive_regulation IRS4 INS 3048247 97186 Whereas [pp160] remains maximally phosphorylated on tyrosine for up to 60 min in the *presence* of 100 , IGF-1 at the same concentration induces only a transient response that is maximally 50 % of that observed with insulin . Positive_regulation ISG15 IL1B 14976045 1243017 Dietary treatment with statins or PPARalpha activators decreased basal and *induced* plasma [huCRP] levels independently of cholesterol lowering . Positive_regulation ISG15 IL1B 20660068 2311010 We hypothesized that ISG15 depletion ( Isg15 ( -/- ) ) alters decidual tissue gene expression and that *induces* [ISG15] expression and isgylation in cultured murine decidual explants and human uterine fibroblasts ( HuFs ) . Positive_regulation ISG15 TNF 22729740 2634189 *Induction* of [ISG15] and its conjugates by was dose dependent and required mediation of p38 MAP kinase and Jak1 through up-regulation of endogenous type I interferon expression . Positive_regulation ISG15 TNF 22729740 2634191 SB202190 ( p38 MAPK inhibitor ) and Jak1 inhibitor suppressed *induced* expression of [ISG15] and its conjugates . Positive_regulation ISG15 TNF 22729740 2634220 Although B18R , a soluble type I interferon receptor , totally abolished the effect of exogenous IFN-ß , it was unable to inhibit completely the *induced* [ISG15] production . Positive_regulation ISM2 VEGFA 19874420 2488982 Furthermore , [ISM] induced EC apoptosis in the *presence* of through a caspase dependent pathway . Positive_regulation ITGA2 C1QTNF1 16195328 1507785 *had* no effects on [alpha(2)beta(1) integrin] I-domain binding to collagen . Positive_regulation ITGA2 EPHB2 12657625 1092238 Treatment of cells with selective mitogen activated protein kinase kinase ( MEK ) inhibitors PD098059 and U0126 showed that [integrin alpha2] expression , cell adhesion , and *activation* of are inhibited in a parallel concentration dependent fashion . Positive_regulation ITGA2 EPHB2 12657625 1092239 Using a real time electric cell impedance sensing technique , it was shown that *dependent* [integrin alpha2] mediated cell micromotion signaling is controlled by autocrine TGF-alpha . Positive_regulation ITGA2 TNF 16079290 1442667 Collectively , these results demonstrate an essential role for MMPs and [alpha2beta1 integrin] in the invasive *response* of 31EG4-2A4 cells to . Positive_regulation ITGA2 TNF 8476430 218503 *increased* the [integrin alpha 2] beta 1 expression and cell attachment to type I collagen in human dermal fibroblasts . Positive_regulation ITGA2B F2R 10624968 658496 Aprotinin at 50 to 200 kallikrein inhibiting units/mL decreased the expression of activated [GP IIb-IIIa] complex in *response* to adenosine diphosphate or activator peptide 6 in a dose dependent manner in both citrated and heparinized whole blood experiments . Positive_regulation ITGA2B F2R 23340049 2769786 The vasodilator stimulated phosphoprotein ( VASP ) phosphorylation assay , multiple electrode aggregometry (MEA) with adenosine diphosphate ( ADP ) , and surface expressions of P-selectin and activated [glycoprotein (GP) IIb/IIIa] in *response* to ADP and activating peptide ( TRAP ) -6 were assessed in 71 obese and 245 nonobese patients . Positive_regulation ITGA2B HES2 17683357 1781389 but not NB-HES *increases* the expression of activated platelet [GP IIb/IIIa] induced by ADP or TRAP . Positive_regulation ITGA2B MAP2K6 11522789 874691 Here we show that GPIb-IX mediated activation of [integrin alpha(IIb)beta] ( 3 ) is inhibited by dominant negative mutants of Raf-1 and MEK1 in a reconstituted integrin activation model in Chinese hamster ovary ( CHO ) cells and that the integrin dependent platelet aggregation induced by either vWF or low dose thrombin is *inhibited* by inhibitors PD98059 and U0126 . Positive_regulation ITGA2B TNF 9878125 557717 In combination , IFN-gamma and *induce* a maximal level of [CD41] and CD42 expression which is also accompanied by an increase in cell size and DNA ploidy level . Positive_regulation ITGA4 ITGB2 11261794 794549 Thus , mediates TEM under most conditions , but [VLA-4] can also *mediate* TEM , although , in contrast to LFA-1 , this requires exogenous chemokines and EC activation . Positive_regulation ITGA4 ITGB2 7532681 292163 LFA-1 alone or [VLA-4] alone is sufficient to mediate most of this migration , and either or VLA-4 is *required* for monocyte migration to joint inflammation . Positive_regulation ITGA4 ITGB2 7759886 307846 3 ) Mac-1 plays a less important role than LFA-1 , as appears to substitute for Mac-1 , and [VLA-4] and LFA-1 can *mediate* much of the adhesion and migration . Positive_regulation ITGA4 TNF 14525968 1185828 stimulation also produced a similar *increase* in [CD49d] mediated adhesion of neutrophils to a vascular cell adhesion molecule-1 ( VCAM-1 ) -coated surface . Positive_regulation ITGA5 CEACAM6 18159236 1838559 The colonocyte surface level of [integrin alpha5] and the activation of AKT *increased* progressively with the expression levels of . Positive_regulation ITGA5 CTGF 18481209 1840585 Moreover , can bind to integrin alpha5beta1 in chondrocytes and can *stimulate* increased expression of [integrin alpha5] . Positive_regulation ITGA5 EPHB2 15825163 1432486 Overall , these findings suggest that COX-2 inhibitors suppress alpha5beta1 integrin expression in NSCLC through effects on [integrin alpha5] gene transcription *mediated* by activation , increased Sp1 , decreased AP-1 DNA binding and inactivation of SAPK/JNK signals . Positive_regulation ITGA5 EPHB2 20558745 2302490 rHSP90alpha induced the activities of , PI3K/Akt , and NF-kappaB p65 , but only NF-kappaB activation was *involved* in HSP90alpha induced [integrin alpha(V)] expression . Positive_regulation ITGA5 PECAM1 16551678 1568189 We now report that homophilic interactions between phagocyte and target cells *lead* to activation of phagocyte [alpha5beta1 integrin] and the engulfment of apoptotic Jurkat T lymphocytes via a fibronectin (Fn) `` bridge . '' Positive_regulation ITGA5 PLAU 12124174 965670 receptor ( uPAR ) *activates* [alpha5beta1 integrin] and ERK signaling , inducing in vivo proliferation of HEp3 human carcinoma . Positive_regulation ITGA5 SPHK1 20522645 2284187 Tumor necrosis factor induced neutrophil adhesion occurs via *dependent* activation of endothelial { [alpha}5{beta}1 integrin] . Positive_regulation ITGA5 TNF 20522645 2284191 Herein we demonstrate that *activates* the [integrin alpha(5)beta] ( 1 ) without altering total expression levels of beta ( 1 ) integrin on human umbilical vein endothelial cells . Positive_regulation ITGA9 ADAM12 16061220 1453993 We demonstrated that phosphoinositide-3-kinase appears to be central in regulating [alpha9beta1 integrin] cell spreading activity in *response* to . Positive_regulation ITGAL ACD 12171996 974320 These findings indicate that available levels of GTP bound are *required* for the direct activation of [LFA-1] and VLA-4 . Positive_regulation ITGAL AKT1 18209096 1857850 CD28 ( - ) T cells , which are overrepresented in RA patients , have high [CD11a] cell surface expression and *induce* phosphorylation in FLS more potently than their CD28 ( + ) counterparts . Positive_regulation ITGAL AKT2 18209096 1857851 CD28 ( - ) T cells , which are overrepresented in RA patients , have high [CD11a] cell surface expression and *induce* phosphorylation in FLS more potently than their CD28 ( + ) counterparts . Positive_regulation ITGAL AKT3 18209096 1857852 CD28 ( - ) T cells , which are overrepresented in RA patients , have high [CD11a] cell surface expression and *induce* phosphorylation in FLS more potently than their CD28 ( + ) counterparts . Positive_regulation ITGAL CALM3 20683899 2311920 Importantly , binding of calmodulin to LPL was required for the maintenance of LPL in the IS and consequently inhibition of also *prevented* stable accumulation of [LFA-1] and Talin , but not CD3 , in the IS . Positive_regulation ITGAL CBFB 10882733 722471 *transactivated* the [CD11a] promoter , with AML1B/CBFbeta mediated transactivation being completely dependent on the integrity of the CD11a-110 element . Positive_regulation ITGAL CCL2 11779737 900103 In *response* to plus E. coli LPS , we observed additional engagement of [CD11a] and CD106 for enhanced alveolar monocyte transmigration . Positive_regulation ITGAL CCR5 11527992 853485 These results indicate that IL-12 plays a critical role in CCR5 expression on Th1 cells and consequently contributes to *mediated* activation of [LFA-1] molecules . Positive_regulation ITGAL CD160 10421651 632328 Activation of liver NK-type cells was also supported by the fact that liver NK cells proportionally increased and ( + ) T cells *augmented* their [CD11a] expressions after SEB injection . Positive_regulation ITGAL CD2 2574829 123419 We postulate that and CD3 can differentially *regulate* the affinity of [LFA-1] for its ligands by modulating its molecular conformation through PKC dependent mechanisms . Positive_regulation ITGAL CD209 15752559 1379956 Surprisingly , initial binding of gp120 to did not *result* in increased adhesion levels of [LFA-1] to its ligand ICAM-1 in both immature DC and Raji-DC-SIGN cells . Positive_regulation ITGAL CD226 10591186 572559 These results indicate that is *involved* in the [LFA-1] mediated intracellular signals . Positive_regulation ITGAL CD226 14676297 1178916 These results suggest that is *involved* in [LFA-1] mediated costimulatory signals for triggering naive T cell differentiation and proliferation . Positive_regulation ITGAL CD3D 1431107 202785 It has been suggested that negative selection involves not only *mediated* signals but also [LFA-1] mediated signals . Positive_regulation ITGAL CD3E 1431107 202786 It has been suggested that negative selection involves not only *mediated* signals but also [LFA-1] mediated signals . Positive_regulation ITGAL CD3G 1431107 202787 It has been suggested that negative selection involves not only *mediated* signals but also [LFA-1] mediated signals . Positive_regulation ITGAL CD44 15631666 1349442 The expression of CD49d , and CD61L on Sca-1 ( + ) cells were similar to that befor expression ( P < 0.05 ) , but the expression of CD49e and [CD11a] on Sca-1 ( + ) cells were remarkably *increased* ( P < 0.05 ) . Positive_regulation ITGAL CD44 15707579 1372857 This shows that cross linking *induces* [LFA-1] and VLA-4 expression in MDA-MB-435S cells and increases integrin mediated adhesion to endothelial cells , resulting in the transendothelial migration of breast cancer cells . Positive_regulation ITGAL CD58 7686816 222319 [CD11a] and CD2 were not *detected* on melanoma cells while CD54 and were coexpressed on the majority of the melanoma cell populations investigated . Positive_regulation ITGAL CD58 7686816 222322 gamma-Interferon and/or tumor necrosis factor alpha upregulated the expression of CD54 by melanoma cells , but neither modulated that of nor *induced* that of [CD11a] and CD2 . Positive_regulation ITGAL CD99 9278313 450942 ( MIC2 ) *regulates* the [LFA-1/ICAM-1] mediated adhesion of lymphocytes , and its gene encodes both positive and negative regulators of cellular adhesion . Positive_regulation ITGAL CPB1 12205934 581468 *caused* a sustained increase in the leukocyte [CD11a] , CD18 , CD11a/CD18 , CD11b/CD18 expression and the plasma sICAM-1 , sE-selectin levels in patients ( P < 0.05 ) . Positive_regulation ITGAL CPB2 12205934 581469 *caused* a sustained increase in the leukocyte [CD11a] , CD18 , CD11a/CD18 , CD11b/CD18 expression and the plasma sICAM-1 , sE-selectin levels in patients ( P < 0.05 ) . Positive_regulation ITGAL CRKL 12697763 1100087 Thus , Cbl-b plays a negative role in mediated Rap1 and [LFA-1] *activation* in T cells . Positive_regulation ITGAL CSF2 10556811 566010 The results indicate that : ( 1 ) GM-CSF can prime monocytes for increased TEM , ( 2 ) enhances LFA-1 mediated monocyte TEM and ( 3 ) this effect is in part *mediated* by increasing [LFA-1] expression and activation . Positive_regulation ITGAL CXCR4 15235585 1281983 Invasion and metastasis of these cells requires *activation* of the integrin [LFA-1] by the chemokine receptor . Positive_regulation ITGAL CXCR4 19812192 2154337 Src homology 2-domain containing leukocyte-specific phosphoprotein of 76 kDa is mandatory for TCR mediated inside-out signaling , but dispensable for mediated [LFA-1] *activation* , adhesion , and migration of T cells . Positive_regulation ITGAL DNMT1 23418509 2744105 Inhibition of ornithine decarboxylase , which is required for polyamine synthesis , in Jurkat cells by 3 mM D , L-alpha-difluoromethylornithine hydrochloride ( DFMO ) significantly decreased spermine and spermidine concentrations and was associated with decreased activity , enhanced demethylation of the LFA-1 gene ( ITGAL ) promoter area , and *increased* [CD11a] expression . Positive_regulation ITGAL DOCK2 12871644 1112538 is *essential* for antigen induced translocation of TCR and lipid rafts , but not PKC-theta and [LFA-1] , in T cells . Positive_regulation ITGAL FCGR1A 10979209 729816 Cross linking of neither [CD11a] nor CD11c *induced* expression . Positive_regulation ITGAL FERMT3 21536861 2449180 is *required* for the stabilization of TCR stimulated [LFA-1] : ICAM-1 bonds critical for lymphocyte arrest and spreading on dendritic cells . Positive_regulation ITGAL HRAS 10688643 670056 and Rac *activated* [LFA-1] in a PI 3-kinase dependent manner , whereas Rho and R-Ras had little effect . Positive_regulation ITGAL ICAM1 1348028 182734 These studies provide evidence that and ICAM-2 are not important *target* cell ligands for NK effector cell [LFA-1] and that other target cell ICAM may exist . Positive_regulation ITGAL ICAM1 15356110 1293161 Expression of on insect cells was *sufficient* to induce lysis by NK cells through [LFA-1] . Positive_regulation ITGAL ICAM1 19557182 2099547 Applying the findings that primary resting T cells absorb nanometric membrane vesicles derived from antigen presenting cells (APC) via dual receptor/ligand interactions of T cell receptor ( TCR ) with cognate peptide-major histocompatibility complex ( MHC ) complex ( pMHC ) and LFA-1 with its ligand , intercellular adhesion molecule-1 ( ICAM-1 ) , and that signaling cascades triggered by TCR/pMHC interaction take a part in the vesicle-absorption , we established a cell based high throughput assay for systematic investigation , via isolation of small molecules modulating the level of vesicle-absorption , of molecular mechanisms underlying the T cell absorption of APC derived vesicles , i.e. , structural basis of TCR/pMHC and interactions and TCR mediated [LFA-1] *activation* . Positive_regulation ITGAL ICAM1 7686816 222320 [CD11a] and CD2 were not *detected* on melanoma cells while and CD58 were coexpressed on the majority of the melanoma cell populations investigated . Positive_regulation ITGAL ICAM2 1348028 182735 These studies provide evidence that ICAM-1 and are not important *target* cell ligands for NK effector cell [LFA-1] and that other target cell ICAM may exist . Positive_regulation ITGAL ICAM3 10639327 660464 Low-affinity interactions *augment* [LFA-1/ICAM-1] mediated T cell adhesion and signaling by redistribution of LFA-1 . Positive_regulation ITGAL IFIT1 16670319 1558525 Previous reports show that ( lck ) activation is *required* for TCR initiated [LFA-1] avidity up-regulation , raising the question : is low LFA-1 avidity the basis of reduced TIL conjugation frequency ? Positive_regulation ITGAL IFNA1 1352710 190378 [CD11a] expression was *induced* by incubation with or interleukin-4 . Positive_regulation ITGAL IFNA10 1352710 190379 [CD11a] expression was *induced* by incubation with or interleukin-4 . Positive_regulation ITGAL IFNA13 1352710 190380 [CD11a] expression was *induced* by incubation with or interleukin-4 . Positive_regulation ITGAL IFNA14 1352710 190381 [CD11a] expression was *induced* by incubation with or interleukin-4 . Positive_regulation ITGAL IFNA16 1352710 190382 [CD11a] expression was *induced* by incubation with or interleukin-4 . Positive_regulation ITGAL IFNA17 1352710 190383 [CD11a] expression was *induced* by incubation with or interleukin-4 . Positive_regulation ITGAL IFNA2 1352710 190384 [CD11a] expression was *induced* by incubation with or interleukin-4 . Positive_regulation ITGAL IFNA21 1352710 190385 [CD11a] expression was *induced* by incubation with or interleukin-4 . Positive_regulation ITGAL IFNA4 1352710 190386 [CD11a] expression was *induced* by incubation with or interleukin-4 . Positive_regulation ITGAL IFNA5 1352710 190387 [CD11a] expression was *induced* by incubation with or interleukin-4 . Positive_regulation ITGAL IFNA6 1352710 190388 [CD11a] expression was *induced* by incubation with or interleukin-4 . Positive_regulation ITGAL IFNA7 1352710 190389 [CD11a] expression was *induced* by incubation with or interleukin-4 . Positive_regulation ITGAL IFNA8 1352710 190390 [CD11a] expression was *induced* by incubation with or interleukin-4 . Positive_regulation ITGAL IFNG 10198263 605155 [CD11a] *induction* by conversely is sensitive to inhibition of Na+/H+ exchange and insensitive to inhibition of protein kinase C . Positive_regulation ITGAL IFNG 11132183 760217 This decrease in both HDL binding and uptake was reversed by the peroxisome proliferator activated receptor gamma ( PPARgamma ) agonist , 15-deoxy-delta12,4-prostaglandin J2 ( 15d-PGJ2 ) , which also inhibited the *induction* of the beta2 integrin [CD11a] . Positive_regulation ITGAL IFNG 12056591 951886 LY465608 inhibited , in a concentration dependent manner , *induction* of both nitric oxide synthesis and the beta 2 integrin [CD11a] in elicited peritoneal macrophages from apoE knockout mice . Positive_regulation ITGAL IFNG 1355014 195695 *enhanced* ICAM-1 expression but not [LFA-1] expression , and PMA augmented both LFA-1 and ICAM-1 expression . Positive_regulation ITGAL IFNG 1358968 200427 Anti-CD3 plus [anti-CD11a] stimulation consistently *induced* the highest secretion of IL-2 and , whereas variation in secretion of TNF-alpha and IL-4 between different donors was noted . Positive_regulation ITGAL IFNG 8542246 331240 The ability of to *induce* the expression of adhesion molecules such [LFA 1] and ICAM 1 on peripheral blood leukaemic cell surfaces may suggest its use in the induction therapy of CML patients . Positive_regulation ITGAL IL10 16313368 1486931 IL-15 and IL-18 increased CD69 receptor expression , while *up-regulated* CD16 and [CD11a] expression in TB . Positive_regulation ITGAL IL12A 11527992 853486 These results indicate that plays a critical role in CCR5 expression on Th1 cells and consequently *contributes* to CCR5 mediated activation of [LFA-1] molecules . Positive_regulation ITGAL IL12A 7903063 237829 Among the beta 2 integrins , selectively *increased* expression of [CD11a] on NK cells , although to a significantly lower level than that induced by IL2 . Positive_regulation ITGAL IL12B 11527992 853487 These results indicate that plays a critical role in CCR5 expression on Th1 cells and consequently *contributes* to CCR5 mediated activation of [LFA-1] molecules . Positive_regulation ITGAL IL12B 7903063 237830 Among the beta 2 integrins , selectively *increased* expression of [CD11a] on NK cells , although to a significantly lower level than that induced by IL2 . Positive_regulation ITGAL IL15 12847234 1108946 *mediated* induction of [LFA-1] is a late step required for cytotoxic differentiation of human NK cells from CD34+Lin- bone marrow cells . Positive_regulation ITGAL IL15 12847234 1108947 IL-2 or also *induced* [LFA-1] . Positive_regulation ITGAL IL1A 8446777 213926 Stimulation of microglial cells with and tumour necrosis factor-alpha , the main cytokines detected in HIV1 infected central nervous system ( CNS ) , *increased* the microglial expression of alpha 1-VLA , intercellular adhesion molecule-1 , vascular cell adhesion molecule-1 and beta [2-LFA-1] ( leukocyte-function associated molecule-1 ) but not of alpha L-LFA-1 . Positive_regulation ITGAL IL1B 15621305 1358426 These findings suggest that BHV-1 infection , and the resulting release of and perhaps other inflammatory cytokines , can *stimulate* activation of [LFA-1] in bystander bovine PMNs , thus enhancing the binding and biological effects of LKT . Positive_regulation ITGAL IL2 12847234 1108948 or IL-15 also *induced* [LFA-1] . Positive_regulation ITGAL IL2 1358968 200428 Anti-CD3 plus [anti-CD11a] stimulation consistently *induced* the highest secretion of and IFN-gamma , whereas variation in secretion of TNF-alpha and IL-4 between different donors was noted . Positive_regulation ITGAL IL2 3074999 104120 The dominant utilization of CD11a did not appear to depend on *induction* of [CD11a] surface expression . Positive_regulation ITGAL IL4 1352710 190391 [CD11a] expression was *induced* by incubation with interferon-alpha (IFN-alpha) or . Positive_regulation ITGAL IL4 2547869 115652 *induces* [LFA-1] and LFA-3 expression on Burkitt 's lymphoma cell lines . Positive_regulation ITGAL IL4 7931169 275230 Monocyte expression of ICAM-1 but not [LFA-1] was significantly *enhanced* by although substrate adherence was a more potent stimulus . Positive_regulation ITGAL IL5 12046991 950173 Olopatadine dose-dependently repressed the *induced* expressions of [CD11a/CD18] ( LFA-1 ) and CD11b/CD18 ( Mac-1 ) on rat peritoneal eosinophils . Positive_regulation ITGAL IL7 9420139 472426 A new *role* for in the induction of [LFA-1] and VLA-4 adhesion molecules in Phorbol 12myristate 13acetate activated CD4+ CD23+ T-cell subset . Positive_regulation ITGAL IL8 9124560 424027 Detailed studies with IFN-gamma stimulated ( 100 U/ml ) C3A cells revealed that this adhesion involved [CD11a/CD18] [ lymphocyte function associated antigen-1 ( LFA-1 ) ] and CD54 and was *dependent* on low levels of produced by the stimulated hepatocytes . Positive_regulation ITGAL ITGA4 10623819 658380 interaction *activates* [alpha L beta 2 integrin] mediated adhesion to ICAM-1 in human T cells . Positive_regulation ITGAL ITGAM 9242371 446008 In vitro , both immunoglobulin A and immunoglobulin G2a CD3 mAbs *induce* immediate activation of [CD11a/CD18] , with concomitant up-regulation of on T cells , each of which is shown to be involved in the concurrent adhesion of T cells to endothelium . Positive_regulation ITGAL ITGB1 10623819 658381 interaction *activates* [alpha L beta 2 integrin] mediated adhesion to ICAM-1 in human T cells . Positive_regulation ITGAL ITGB2 19557182 2099548 Applying the findings that primary resting T cells absorb nanometric membrane vesicles derived from antigen presenting cells (APC) via dual receptor/ligand interactions of T cell receptor ( TCR ) with cognate peptide-major histocompatibility complex ( MHC ) complex ( pMHC ) and LFA-1 with its ligand , intercellular adhesion molecule-1 ( ICAM-1 ) , and that signaling cascades triggered by TCR/pMHC interaction take a part in the vesicle-absorption , we established a cell based high throughput assay for systematic investigation , via isolation of small molecules modulating the level of vesicle-absorption , of molecular mechanisms underlying the T cell absorption of APC derived vesicles , i.e. , structural basis of TCR/pMHC and interactions and TCR mediated [LFA-1] *activation* . Positive_regulation ITGAL ITGB2 1976304 141699 Retroviral mediated gene transfer of into LAD EBV B-cells *resulted* in low , but readily measurable , levels of surface expression of the [CD11a/CD18] complex in these previously deficient lymphocytes . Positive_regulation ITGAL ITGB2 2978519 104115 mediates the binding of killer T cells to targets , CR3 mediates binding of phagocytes to iC3b coated surfaces and to endothelial cells , and [LFA-1] , CR3 , and p150 ,95 each *mediate* the binding of bacterial lipopolysaccharide . Positive_regulation ITGAL ITGB2 7759886 307847 3 ) Mac-1 plays a less important role than LFA-1 , as appears to substitute for Mac-1 , and VLA-4 and [LFA-1] can *mediate* much of the adhesion and migration . Positive_regulation ITGAL ITGB2 9242371 446009 In vitro , both immunoglobulin A and immunoglobulin G2a CD3 mAbs *induce* immediate activation of [CD11a/CD18] , with concomitant up-regulation of on T cells , each of which is shown to be involved in the concurrent adhesion of T cells to endothelium . Positive_regulation ITGAL ITGB3 15631666 1349443 The expression of CD49d , Cd44 and on Sca-1 ( + ) cells were similar to that befor expression ( P < 0.05 ) , but the expression of CD49e and [CD11a] on Sca-1 ( + ) cells were remarkably *increased* ( P < 0.05 ) . Positive_regulation ITGAL ITIH4 15752559 1379957 Surprisingly , initial binding of to DC-SIGN did not *result* in increased adhesion levels of [LFA-1] to its ligand ICAM-1 in both immature DC and Raji-DC-SIGN cells . Positive_regulation ITGAL ITIH4 21284901 2387900 interactions *mediate* the activation of the adhesion associated integrin [LFA-1] . Positive_regulation ITGAL ITIH4 9257821 448510 Cocapping experiments showed that *induced* CD4 association with CD38 , CD29 , CD49d , and [CD11a] in peripheral blood CD4+ T cells . Positive_regulation ITGAL LCK 11698443 878013 We find that conjugate formation between Jurkat T cells and EBV-B cells presenting superantigen is mediated by [LFA-1] and absolutely *requires* . Positive_regulation ITGAL MAP4K1 23682030 2785487 Gim me a brake : *regulates* [LFA-1] and neutrophil traction . Positive_regulation ITGAL MBP 8409119 233327 *stimulated* minimal increases in [LFA-1] expression . Positive_regulation ITGAL MRAS 17538012 1773202 Finally , we demonstrated that and RA-GEF-2 were indeed *involved* in TNF-alpha stimulated and Rap1 mediated [LFA-1] activation in splenocytes by using mice deficient in RA-GEF-2 . Positive_regulation ITGAL NAPA 11259095 795660 *induced* also an increased expression of both [Lymphocyte Function-Associated-1 (LFA-1)] and Intercellular Adhesion Molecule-1 ( ICAM-1 ) , which was obvious from 18 hour incubation with NaPa for the MDA-MB-231 cells , but was delayed ( 3 days ) for MCF-7 and MCF-7 ras . Positive_regulation ITGAL PARP1 8871630 389565 Modification of [LFA-1] *requires* expression of the cell surface and causes the loss of epitopes recognized by alpha- and beta-chain-specific Abs. Concomitantly , the generation of inositol phosphates induced by Ab cross linking of LFA-1 is significantly inhibited . Positive_regulation ITGAL PIK3CA 16339552 1491641 Although activity is *required* for optimal [LFA-1] mediated adhesion and cell spreading , this most likely does not account for its full contribution to degranulation . Positive_regulation ITGAL PIK3R1 16339552 1491642 Although activity is *required* for optimal [LFA-1] mediated adhesion and cell spreading , this most likely does not account for its full contribution to degranulation . Positive_regulation ITGAL POT1 12171996 974318 These findings indicate that available levels of GTP bound are *required* for the direct activation of [LFA-1] and VLA-4 . Positive_regulation ITGAL PTPRC 7908233 250475 We conclude that cross linking the on T cells *induces* [LFA-1] -- /ICAM-1 -- dependent T-cell -- monocyte aggregation through a unique signaling pathway independent of PKC , which involves instead cAMP-/cGMP dependent protein kinases . Positive_regulation ITGAL PXN 22274710 2520565 Central *role* of phosphorylation in regulation of [LFA-1] integrins activity and lymphocyte migration . Positive_regulation ITGAL RAC1 10688643 670057 H-Ras and *activated* [LFA-1] in a PI 3-kinase dependent manner , whereas Rho and R-Ras had little effect . Positive_regulation ITGAL RAC1 19136961 2025511 We found that the small GTPase *mediated* chemokine induced [LFA-1] affinity triggering and lymphocyte arrest in high endothelial venules . Positive_regulation ITGAL RAC2 10688643 670058 H-Ras and *activated* [LFA-1] in a PI 3-kinase dependent manner , whereas Rho and R-Ras had little effect . Positive_regulation ITGAL RAC3 10688643 670059 H-Ras and *activated* [LFA-1] in a PI 3-kinase dependent manner , whereas Rho and R-Ras had little effect . Positive_regulation ITGAL RAD50 12171996 974321 These findings indicate that available levels of GTP bound are *required* for the direct activation of [LFA-1] and VLA-4 . Positive_regulation ITGAL RAPGEF1 12697763 1100088 Thus , Cbl-b plays a negative role in mediated Rap1 and [LFA-1] *activation* in T cells . Positive_regulation ITGAL RAPGEF2 17538012 1773201 Finally , we demonstrated that M-Ras and were indeed *involved* in TNF-alpha stimulated and Rap1 mediated [LFA-1] activation in splenocytes by using mice deficient in RA-GEF-2 . Positive_regulation ITGAL RFX1 21192791 2360643 *regulates* CD70 and [CD11a] expression in lupus T cells by recruiting the histone methyltransferase SUV39H1 . Positive_regulation ITGAL RUNX1 10882733 722470 *transactivated* the [CD11a] promoter , with AML1B/CBFbeta mediated transactivation being completely dependent on the integrity of the CD11a-110 element . Positive_regulation ITGAL RUNX1 12855590 1149915 and C/EBP factors *regulate* [CD11a] integrin expression in myeloid cells through overlapping regulatory elements . Positive_regulation ITGAL RUNX2 12855590 1149916 and C/EBP factors *regulate* [CD11a] integrin expression in myeloid cells through overlapping regulatory elements . Positive_regulation ITGAL RUNX3 12855590 1149917 and C/EBP factors *regulate* [CD11a] integrin expression in myeloid cells through overlapping regulatory elements . Positive_regulation ITGAL RUNX3 16164020 1456207 *regulates* the activity of the [CD11a] and CD49d integrin gene promoters . Positive_regulation ITGAL RUNX3 16164020 1456210 The functional relevance of these elements are illustrated by the fact that overexpression *leads* to enhanced [CD11a/CD18] levels , whereas RUNX1-ETO expressing cells exhibit a weak/absent CD11a/CD18 integrin cell surface expression . Positive_regulation ITGAL SLC25A3 9723775 529263 Results suggest that protein phosphatase 2A (PP2A) is not involved in these processes whereas negatively *regulate* [LFA-1] expression and tumour-cell binding of cisplatin treated macrophages . Positive_regulation ITGAL SPN 17996943 1866779 These results indicate that triggering CD43 and the underlying signaling pathways enhance LFA-1 adhesiveness while also negatively *regulates* [LFA-1] induction via other receptors by dynamic interaction with either LFA-1 or CD147 . Positive_regulation ITGAL TERF1 12171996 974315 These findings indicate that available levels of GTP bound are *required* for the direct activation of [LFA-1] and VLA-4 . Positive_regulation ITGAL TERF2 12171996 974316 These findings indicate that available levels of GTP bound are *required* for the direct activation of [LFA-1] and VLA-4 . Positive_regulation ITGAL TERF2IP 12171996 974319 These findings indicate that available levels of GTP bound are *required* for the direct activation of [LFA-1] and VLA-4 . Positive_regulation ITGAL THY1 1676986 161013 This indicates that , unlike treatment with PMA , anti-CD2 mAb or anti-CD3 mAb , mAb treatment of T lymphocytes does not *induce* [LFA-1] activation for cell adhesion . Positive_regulation ITGAL TINF2 12171996 974317 These findings indicate that available levels of GTP bound are *required* for the direct activation of [LFA-1] and VLA-4 . Positive_regulation ITGAL TLN1 17114441 1651459 In this study , we show that the cytoskeletal protein is *required* for TCR mediated activation of [LFA-1] through regulation of LFA-1 affinity and clustering . Positive_regulation ITGAL TLN1 19124737 2019559 A dual role for in NK cell cytotoxicity : *activation* of [LFA-1] mediated cell adhesion and polarization of NK cells . Positive_regulation ITGAL TLN2 19124737 2019560 A dual role for in NK cell cytotoxicity : *activation* of [LFA-1] mediated cell adhesion and polarization of NK cells . Positive_regulation ITGAL TNF 12615677 1065479 Moreover , simvastatin , atorvastatin , and cerivastatin were found to downregulate *induced* expression of CD54 and [CD18/CD11a] in isolated PBMCs obtained from normal donors as well as TNF-alpha dependent expression of these CAMs in cultured human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation ITGAL TNF 14688105 1190342 Northern and Western blotting analyses showed that *enhanced* the expression of [CD11a] in the cells at both the mRNA and protein levels but did not do so for CD18 expression . Positive_regulation ITGAL VAV1 12616499 1065711 Furthermore we demonstrate that is *required* for TCR induced activation of the integrin [LFA-1] , which is likely to explain the defect in conjugate formation . Positive_regulation ITGAL VCAM1 10623819 658379 Alpha 4 beta 1 interaction *activates* [alpha L beta 2 integrin] mediated adhesion to ICAM-1 in human T cells . Positive_regulation ITGAM ALOX5 15006623 1217627 The increase in the expression of [Mac-1] was not *inhibited* by <5-lipoxygenase> inhibitor ( AA861 ) . Positive_regulation ITGAM CD14 12747235 1088830 LPS induced [CD11b] expression was *dependent* on binding of LPS to the surface protein as CD14 antibodies inhibited LPS dependent CD11b upregulation . Positive_regulation ITGAM F3 21070799 2376535 *contributes* to neutrophil [CD11b] expression in alpha-naphthylisothiocyanate treated mice . Positive_regulation ITGAM IL1B 10845922 700726 Engagement of [CD11b] and CD11c beta2 integrin by antibodies or soluble CD23 *induces* production on primary human monocytes through mitogen activated protein kinase dependent pathways . Positive_regulation ITGAM IL1B 11698472 878079 also *induced* O ( 2 ) ( - ) release and up-regulation of [CD11b] and CD15 , and both responses were inhibited by SB203580 ( p38 MAPK inhibitor ) , suggesting that p38 MAPK activation mediates IL-1beta induced O ( 2 ) ( - ) release and up-regulation of CD11b and CD15 . Positive_regulation ITGAM IL1B 11698472 878107 These findings suggest that 1 ) in human neutrophils the MKK3/6-p38 MAPK cascade is selectively activated by and activation of this cascade *mediates* IL-1beta induced O ( 2 ) ( - ) release and up-regulation of [CD11b] and CD15 , and 2 ) the IL-1R-p38 MAPK pathway and the G-CSF receptor-ERK pathway work independently for activation of neutrophils . Positive_regulation ITGAM IL1B 9523024 493889 Coincubation of neutrophils with alpha-Toc and pretreatment of HUVEC with alpha-Toc significantly reduced PAF induced [CD11b/CD18] expression and induced *upregulation* of ICAM-1 and VCAM-1 , respectively . Positive_regulation ITGAM ITGAL 23250325 2724668 TNF-a also induced neutrophil and [Mac-1] *activation* , but this activation was not blocked by simvastatin . Positive_regulation ITGAM ITGB2 11287316 800028 Phosphorylation of p92 was inducible when [Mac-1] was *activated* by phorbol 12-myristate 13-acetate , the beta ( 2 ) -specific activating antibody CBR , or interleukin-8 ( 77 amino acids ) . Positive_regulation ITGAM ITGB2 22017400 2539836 Depletion of by RNA interference *leads* to parallel down-regulation of [CD11b] and CD11c , as well as of paxillin , and the disappearance of the adhesion-like coats . Positive_regulation ITGAM NGFR 20566383 2290326 K252a , the inhibitor , *inhibits* fMLP or EGF associated ROS production , [CD11b] expression and EGF induced EGFR phosphorylation ; Positive_regulation ITGAM PLAU 23060546 2685563 MDSC can be recruited by , and uPAR but not [CD11b] are *required* for such recruitment . Positive_regulation ITGAM SELL 8831236 385725 EM down-regulated expression , and *inhibited* up regulation of [Mac-1] expression on peripheral blood neutrophils . Positive_regulation ITGAM TLR7 19708080 2158103 *activated* [CD11b] ( + ) Ly6C ( hi ) Ly6G ( - ) cells also enhance liver natural killer T cell ( NKT ) death in an Fas dependent manner . Positive_regulation ITGAM TLR7 23573259 2768094 *induced* [CD11b] and L-selectin response in patients with coronary artery disease . Positive_regulation ITGAM TM4SF19 10529602 561987 Cross linking of some surface molecules *induced* significant eosinophil homotypic aggregation , upregulation of [CD11b] expression , or CD62L shedding , consistent with activation of eosinophils . Positive_regulation ITGAM TNF 10843415 700076 TNF-alpha caused a significant increase in PMNL CD 11b/CD18 expression after 30 min of incubation at 37 degrees C . added simultaneously with the bacteria *induced* a significant increase in PMNL [CD11b/CD18] in both strains . Positive_regulation ITGAM TNF 11813158 907411 in contrast *caused* a small decrease in cell deformability only after 30 min , and shedding of L-selectin , but no change in [CD11b] levels . Positive_regulation ITGAM TNF 12577469 1029625 Progesterone inhibited *stimulated* CD54 and [CD11b] expression on the granulocytes and CD69 expression on lymphocytes by reducing partly the density of these molecules on the surface of cells , and in such way it partly blocked the proinflammatory activity of this cytokine . Positive_regulation ITGAM TNF 1356917 198071 The mean fluorescence intensity ( MFI ) of monocyte CD11a was enhanced by interleukin-2 (IL-2) , TNF-alpha and TNF-beta , and that of [CD11b] , CD11c and CD18 was *increased* by IL-2 , IL-4 , and TNF-beta . Positive_regulation ITGAM TNF 15046557 1224953 Conversely , , IL-6 , and IL-8 *increased* reactive oxygen species production and the expression of [CD11b] and CD15 on both neutrophils and monocytes and decreased the expression of CD62L . Positive_regulation ITGAM TNF 1686023 175347 The mean fluorescence intensity of granulocyte CD18 was also increased by the above cytokines , whilst that of [CD11b] was only *increased* by . Positive_regulation ITGAM TNF 17197441 1702259 Additionally , *induced* the association of [CD11b/CD18] with the NADPH oxidase subunit Nox2 ( gp91(phox) ) and phosphorylation of p47(phox) , indicating the CD11b/CD18 dependence of NADPH oxidase activation . Positive_regulation ITGAM TNF 18164590 1855575 *induces* integrin [CD11b/CD18] ( Mac-1 ) up-regulation and migration to the CC chemokine CCL3 ( MIP-1alpha ) on human neutrophils through defined signalling pathways . Positive_regulation ITGAM TNF 18164590 1855577 TNF-alpha induced migration was a consequence of the induced *up-regulation* of integrin [CD11b/CD18] ( Mac-1 ) on neutrophil surface . Positive_regulation ITGAM TNF 18256785 1877315 *enhanced* [CD11b] expression and percent of cell population in the G1 phase induced by DMSO , which are hallmarks for HL-60 cell differentiation . Positive_regulation ITGAM TNF 19162037 2053978 Furthermore , JWH-133 inhibited the *induced* chemotaxis and integrin [CD18/CD11b] ( Mac-1 ) upregulation on human neutrophils . Positive_regulation ITGAM TNF 22086659 2718859 In 38 subjects ( mean age 85 years ) , consecutively enrolled from Belfast Elderly Longitudinal Free Living Aging Study ( BELFAST ) , baseline and *stimulated* [CD11b/CD18] expression on separated monocytes and neutrophils increased with systolic blood pressure > 120 mmHg ( p = 0.05 ) and for lymphocytes , with diastolic blood pressure > 80 mmHg ( p < 0.05 ) . Positive_regulation ITGAM TNF 23110133 2695336 The combination of TNF-a , TGF-ß , and M-CSF induced Kat1 ( + ) [CD11b] ( + ) cells , but these cells were also *induced* by alone . Positive_regulation ITGAM TNF 23250325 2724666 Neutrophil surface expression of the [Mac-1] integrin subunit , CD11b , was *augmented* by , and this increased expression was also inhibited by simvastatin . Positive_regulation ITGAM TNF 23250325 2724667 also *induced* neutrophil LFA-1 and [Mac-1] activation , but this activation was not blocked by simvastatin . Positive_regulation ITGAM TNF 23462755 2760707 *induced* ICAM-1 expression , eNOS dephosphorylation , cytoskeletal changes , and [CD11b/18] expression in neutrophils were significantly suppressed by fasudil as well as ROCK-specific siRNA . Positive_regulation ITGAM TNF 7578989 333405 PTX reduced [CD11b] upregulation *induced* by . Positive_regulation ITGAM TNF 8283134 247454 Complement and *contribute* to [Mac-1] ( CD11b/CD18 ) up-regulation and systemic neutrophil activation during endotoxemia in vivo . Positive_regulation ITGAM TNF 8959153 401904 Stimulation of AM with *increased* H2O2 production and [CD11b/CD18] expression . Positive_regulation ITGAM TNF 9008610 410851 Pretreatment of neutrophils with either NSAID prevented the changes in L-selectin and [CD11b] expression *induced* by , GM-CSF , and FMLP , but not those induced by PMA or A23187 . Positive_regulation ITGAM TNF 9854504 555016 *induced* [CD11b/CD18] expression on leukocytes and interferon-gamma (IFN-gamma) induced ICAM-1 expression on tumor cells may play an important role in leukocyte mediated tumor destruction . Positive_regulation ITGAV CCND1 9314544 455531 Hox D3 antisense *blocked* the ability of bFGF to induce uPA and [integrin alphavbeta3] expression , yet had no effect on EC cell proliferation or bFGF mediated expression . Positive_regulation ITGAV EPHB2 19581046 2194855 Taken together , the data suggest that VEGF is critical to the invasive process in human gastric cancer and that this occurs via up-regulation of [integrin alphavbeta6] expression and *activation* of . Positive_regulation ITGAV MMP28 16230401 1470107 Here , we have investigated the dependency of in vitro angiogenesis on *mediated* extracellular proteolysis and [integrin alpha(v)beta3] mediated cell adhesion in a three-dimensional collagen I model . Positive_regulation ITGAV MMP7 16230401 1470122 Here , we have investigated the dependency of in vitro angiogenesis on *mediated* extracellular proteolysis and [integrin alpha(v)beta3] mediated cell adhesion in a three-dimensional collagen I model . Positive_regulation ITGAV PECAM1 10438720 634990 CD31 stimulation of HUVECs increased the adhesive function of alphavbeta3 integrin to its ligand RGD peptide , the binding of which reached a maximum at 10 minutes after the stimulation , and the induced [alphavbeta3 integrin] *activation* on HUVECs was inhibited by inhibitors of protein kinase C and phosphatidylinositol 3 kinase ( PI3-kinase ) . Positive_regulation ITGAV PECAM1 10438720 634998 These results indicate that mediated inside-out signaling *activates* [alphavbeta3 integrin] on endothelial cells , that the heterophilic alphavbeta3 integrin/CD31 interaction induces beta1 integrin mediated adhesion of eosinophils to endothelial cells , and that the heterophilic interaction itself is not significantly involved in firm adhesion of eosinophils to endothelial cells . Positive_regulation ITGAV TNF 15273742 1296415 *regulates* epithelial expression of MMP-9 and [integrin alphavbeta6] during tumour promotion . Positive_regulation ITGAX ANGPT1 21129919 2372688 Interestingly , combined keratinocyte derived overexpression *reduced* significantly the number of F4/80 ( + ) and [Cd11c] ( + ) cells compared to mice overexpressing epidermal Ang1 alone . Positive_regulation ITGAX IL1B 10845922 700727 Engagement of CD11b and [CD11c] beta2 integrin by antibodies or soluble CD23 *induces* production on primary human monocytes through mitogen activated protein kinase dependent pathways . Positive_regulation ITGAX ITGB2 22017400 2539837 Depletion of by RNA interference *leads* to parallel down-regulation of CD11b and [CD11c] , as well as of paxillin , and the disappearance of the adhesion-like coats . Positive_regulation ITGAX TLR7 23679126 2805807 stimulation significantly *increased* IDO protein level in CD14 ( + ) , CD56 ( + ) , CD1c ( + ) , [CD11c] ( + ) , and CD123 ( + ) myeloid cells . Positive_regulation ITGAX TNF 1356917 198069 The percentage of monocytes bearing CD11b molecules was enhanced by tumour necrosis factor-beta (TNF-beta) , whilst that of [CD11c] was *increased* by both and TNF-beta . Positive_regulation ITGAX TNF 1356917 198074 The mean fluorescence intensity ( MFI ) of monocyte CD11a was enhanced by interleukin-2 (IL-2) , TNF-alpha and TNF-beta , and that of CD11b , [CD11c] and CD18 was *increased* by IL-2 , IL-4 , and TNF-beta . Positive_regulation ITGAX TNF 18484240 1933500 There was a difference in the expression of CD80 , CD83 and CD86 among [CD11c] ( + ) cells *induced* by G-CSF plus and those generated by interleukin-3 , stem cell factor , and erythropoietin plus TNF-alpha . Positive_regulation ITGAX TNF 23353170 2734189 The DCs were then co-cultured with UC-MSCs in the *presence* of for 2 days , and the expressions of [CD11c] and CD86 on DCs and IL-12 level in the culture medium was detected using flow cytometry and ELISA , respectively . Positive_regulation ITGB1 ANGPT1 19916173 2166597 Transfection of into human gastric cancer cell line BGC-823 can significantly *increase* expression of [integrin beta1] and CD44V6 , by which cell adhesion and metastasis to the ECM are promoted . Positive_regulation ITGB1 C1QTNF1 16195328 1507786 *had* no effects on [alpha(2)beta(1) integrin] I-domain binding to collagen . Positive_regulation ITGB1 ITGB2 11261794 794550 Thus , mediates TEM under most conditions , but [VLA-4] can also *mediate* TEM , although , in contrast to LFA-1 , this requires exogenous chemokines and EC activation . Positive_regulation ITGB1 ITGB2 7532681 292164 alone or VLA-4 alone is sufficient to mediate most of this migration , and either LFA-1 or [VLA-4] is *required* for monocyte migration to joint inflammation . Positive_regulation ITGB1 ITGB2 7759886 307848 3 ) Mac-1 plays a less important role than LFA-1 , as appears to substitute for Mac-1 , and [VLA-4] and LFA-1 can *mediate* much of the adhesion and migration . Positive_regulation ITGB1 PECAM1 16551678 1568190 We now report that homophilic interactions between phagocyte and target cells *lead* to activation of phagocyte [alpha5beta1 integrin] and the engulfment of apoptotic Jurkat T lymphocytes via a fibronectin (Fn) `` bridge . '' Positive_regulation ITGB1 PLAU 12124174 965671 receptor ( uPAR ) *activates* [alpha5beta1 integrin] and ERK signaling , inducing in vivo proliferation of HEp3 human carcinoma . Positive_regulation ITGB1 SPHK1 20522645 2284188 Tumor necrosis factor induced neutrophil adhesion occurs via dependent *activation* of endothelial { [alpha}5{beta}1 integrin] . Positive_regulation ITGB1 TNF 16079290 1442668 Collectively , these results demonstrate an essential role for MMPs and [alpha2beta1 integrin] in the invasive *response* of 31EG4-2A4 cells to . Positive_regulation ITGB2 ACD 20957749 2343702 Active , via its binding to RapL ( regulator for cell adhesion and polarization enriched in lymphoid tissues ) , *mediates* [LFA-1] integrin activation . Positive_regulation ITGB2 AKT1 14960575 1227755 We have identified Vav , a guanine nucleotide exchange factor for Rac-1 , and PI3K/Akt , as regulators of the activation and inactivation phases of the activity of Rac-1 , respectively , in the context of LFA-1 signaling based on the following experimental evidence : ( i ) [LFA-1] induced *activation* of Vav and with kinetics consistent with a regulatory role for these molecules on Rac-1 , ( ii ) overexpression of a constitutively active Vav mutant induces activation of Rac independently of LFA-1 stimulation whereas overexpression of a dominant negative Vav mutant blocks LFA-1 mediated Rac activation , ( iii ) pharmacological inhibition of PI3K/Akt prevented the fall in the activity of Rac-1 after its initial activation but had no effect on Vav activity , and ( iv ) overexpression of a dominant negative or a constitutively active Akt-1 induced or inhibited , respectively , Rac-1 activity . Positive_regulation ITGB2 AKT1 23935932 2826749 Adiponectin inhibits neutrophil phagocytosis of Escherichia coli by inhibition of and ERK 1/2 MAPK signalling and [Mac-1] *activation* . Positive_regulation ITGB2 AKT2 14960575 1227756 We have identified Vav , a guanine nucleotide exchange factor for Rac-1 , and PI3K/Akt , as regulators of the activation and inactivation phases of the activity of Rac-1 , respectively , in the context of LFA-1 signaling based on the following experimental evidence : ( i ) [LFA-1] induced *activation* of Vav and with kinetics consistent with a regulatory role for these molecules on Rac-1 , ( ii ) overexpression of a constitutively active Vav mutant induces activation of Rac independently of LFA-1 stimulation whereas overexpression of a dominant negative Vav mutant blocks LFA-1 mediated Rac activation , ( iii ) pharmacological inhibition of PI3K/Akt prevented the fall in the activity of Rac-1 after its initial activation but had no effect on Vav activity , and ( iv ) overexpression of a dominant negative or a constitutively active Akt-1 induced or inhibited , respectively , Rac-1 activity . Positive_regulation ITGB2 AKT3 14960575 1227757 We have identified Vav , a guanine nucleotide exchange factor for Rac-1 , and PI3K/Akt , as regulators of the activation and inactivation phases of the activity of Rac-1 , respectively , in the context of LFA-1 signaling based on the following experimental evidence : ( i ) [LFA-1] induced *activation* of Vav and with kinetics consistent with a regulatory role for these molecules on Rac-1 , ( ii ) overexpression of a constitutively active Vav mutant induces activation of Rac independently of LFA-1 stimulation whereas overexpression of a dominant negative Vav mutant blocks LFA-1 mediated Rac activation , ( iii ) pharmacological inhibition of PI3K/Akt prevented the fall in the activity of Rac-1 after its initial activation but had no effect on Vav activity , and ( iv ) overexpression of a dominant negative or a constitutively active Akt-1 induced or inhibited , respectively , Rac-1 activity . Positive_regulation ITGB2 ALOX5 8773578 379616 However , the [Mac-1] induction by PLA2-II was not *inhibited* by a <5-lipoxygenase> , cyclooxygenase inhibitor , or a platelet activating factor antagonist . Positive_regulation ITGB2 ANPEP 9683105 521408 The expression of ( CD13 ) , C3bi receptor ( CD11b ) , and the neutrophil beta2 integrin unit ( CD18 ) did not change during the administration of G-CSF , but that of both CD13 and [CD18] *increased* 3 days after the last dose . Positive_regulation ITGB2 APOB 11849649 912861 Our results showed that : ( 1 ) oxidized ( and MCP-1 ) *induced* both [LFA-1] mediated adhesion of monocytes to endothelial cells and transendothelial migration of monocytes ; Positive_regulation ITGB2 APOB 7531948 291974 Incubation ( 30 minutes at 37 C ) of whole blood ( diluted with buffered saline to 1 x 10 ( 6 ) leukocytes/ml ) with oxLDL ( 0.85 mg LDL cholesterol/ml ; oxidized by 7.5 mumol/L Cu2+ for 18 hours ) but not native *stimulated* the upregulation of [CD11b/CD18] adhesion receptors on neutrophils ( anti-leu-15 binding : 178 +/- 16 % of baseline , P < 0.01 , means +/- SD of n = 10 experiments ) and on monocytes ( 169 +/- 34 % of baseline , P < 0.01 ) . Positive_regulation ITGB2 APOB 8782841 380481 Oxidized *induces* cell adhesion molecule [Mac-1] ( CD 11b ) and enhances adhesion of the monocytic cell line U937 to cultured endothelial cells . Positive_regulation ITGB2 BDKRB2 23275384 2737585 stimulation *induced* [CD18] activation in early outgrowth cells of healthy subjects , but not in early outgrowth cells of CAD patients . Positive_regulation ITGB2 C3 9916743 587540 *induced* selective shedding of L-selectin and an increase in [alphaMbeta2 integrin] expression on eosinophils but not neutrophils , while C5a induced shedding of L-selectin and up-regulation of alphaMbeta2 integrin on both eosinophils and neutrophils . Positive_regulation ITGB2 C5 1956719 172509 Platelet activating factor and recombinant produced modest *increases* in eosinophil [Mac-1] expression , while N-formyl-met-leu-phe and leukotriene B4 had minimal effects . Positive_regulation ITGB2 C5 19789912 2180556 In vitro PMN *dependent* chemotactic response ( 7 patients ) as well as L-selectin shedding and [Mac-1] expression ( 3 patients ) was determined . Positive_regulation ITGB2 C5 3924634 49110 Stimulation of normal granulocytes with f-Met-Leu-Phe , , or calcium ionophore resulted in increased expression of Mo1 and Leu M5 antigens on the cell surface , but did not significantly *increase* expression of [LFA-1] antigen . Positive_regulation ITGB2 C5 7514872 257084 In contrast , similar to previous studies , recombinant , recombinant IL-8 and FMLP all *stimulated* increased expression of [CD11b/CD18] ( 170-260 % of basal , P < 0.001 , n = 5 ) and shedding of L-selectin ( 56-75 % reduction from basal , P < 0.001 , n = 5 ) at similar concentrations and with similar potencies ( EC50 = 2 , 5 , and 3 nM respectively ) . Positive_regulation ITGB2 C5 7537984 301111 *increased* the expression of [CD18] ( the common subunit of beta 2 integrins ) on PMN by nearly twofold and decreased levels of L-selectin by 50 % within 15 minutes after administration . Positive_regulation ITGB2 C5 8167155 254945 Multiple signalling pathways in the *induced* expression of adhesion receptor [Mac-1] . Positive_regulation ITGB2 C5 8864548 388970 PGE1 ( 10 ( -7 ) M ) decreased PAF- and *induced* upregulation of [CD18] by 93 % and 62 % , respectively . Positive_regulation ITGB2 C5 8926043 386321 We demonstrate in this report that *upregulates* [CD11b/CD18] in human neutrophils . Positive_regulation ITGB2 C5 9916743 587541 C3a induced selective shedding of L-selectin and an increase in alphaMbeta2 integrin expression on eosinophils but not neutrophils , while *induced* shedding of L-selectin and up-regulation of [alphaMbeta2 integrin] on both eosinophils and neutrophils . Positive_regulation ITGB2 CA2 1702813 151311 Together these data suggest a *dependent* conformational change in [Mac-1] , which allows distinction of the roles of Mac-1 in phagocytosis and adhesion . Positive_regulation ITGB2 CA2 7510713 249992 We conclude that is *involved* in avidity regulation of [LFA-1] by clustering of LFA-1 molecules at the cell surface , whereas Mg2+ is important in regulation of the affinity of LFA-1 for its ligands . Positive_regulation ITGB2 CA2 7525820 277016 Cross linking of [CD18] in human neutrophils *induces* an increase of intracellular free , exocytosis of azurophilic granules , quantitative up-regulation of CD18 , shedding of L-selectin , and actin polymerization . Positive_regulation ITGB2 CA2 9560195 500340 CBRM1/20 binds to [Mac-1] in the *presence* of or Sr2+ with an EC50 of 0.2 mM . Positive_regulation ITGB2 CALM3 9723775 529265 Inhibitors of protein phosphatase 1 (PP1) , protein kinase C ( PKC ) , protein tyrosine kinase (PTK) , and calmodulin dependent kinase-II (CamK II) *prevented* [LFA-1] expression on cisplatin treated macrophages . Positive_regulation ITGB2 CALML3 19242347 2050689 Furthermore , *up-regulated* [Mac-1] expression on neutrophils and increased the number of neutrophils binding platelets in the circulation . Positive_regulation ITGB2 CALML3 21330348 2420246 Inhibition of CD40L reduced *induced* up-regulation of [Mac-1] on neutrophils . Positive_regulation ITGB2 CAPN1 20479866 2263180 Our findings demonstrate that 4 is not *necessary* for [LFA-1] mediated adhesion , conjugation or migration . Positive_regulation ITGB2 CAPN10 20479866 2263181 Our findings demonstrate that 4 is not *necessary* for [LFA-1] mediated adhesion , conjugation or migration . Positive_regulation ITGB2 CAPN11 20479866 2263182 Our findings demonstrate that 4 is not *necessary* for [LFA-1] mediated adhesion , conjugation or migration . Positive_regulation ITGB2 CAPN12 20479866 2263179 Our findings demonstrate that 4 is not *necessary* for [LFA-1] mediated adhesion , conjugation or migration . Positive_regulation ITGB2 CAPN13 20479866 2263190 Our findings demonstrate that 4 is not *necessary* for [LFA-1] mediated adhesion , conjugation or migration . Positive_regulation ITGB2 CAPN14 20479866 2263191 Our findings demonstrate that 4 is not *necessary* for [LFA-1] mediated adhesion , conjugation or migration . Positive_regulation ITGB2 CAPN15 20479866 2263178 Our findings demonstrate that 4 is not *necessary* for [LFA-1] mediated adhesion , conjugation or migration . Positive_regulation ITGB2 CAPN2 20479866 2263183 Our findings demonstrate that 4 is not *necessary* for [LFA-1] mediated adhesion , conjugation or migration . Positive_regulation ITGB2 CAPN3 20479866 2263184 Our findings demonstrate that 4 is not *necessary* for [LFA-1] mediated adhesion , conjugation or migration . Positive_regulation ITGB2 CAPN5 20479866 2263185 Our findings demonstrate that 4 is not *necessary* for [LFA-1] mediated adhesion , conjugation or migration . Positive_regulation ITGB2 CAPN6 20479866 2263186 Our findings demonstrate that 4 is not *necessary* for [LFA-1] mediated adhesion , conjugation or migration . Positive_regulation ITGB2 CAPN7 20479866 2263187 Our findings demonstrate that 4 is not *necessary* for [LFA-1] mediated adhesion , conjugation or migration . Positive_regulation ITGB2 CAPN8 20479866 2263188 Our findings demonstrate that 4 is not *necessary* for [LFA-1] mediated adhesion , conjugation or migration . Positive_regulation ITGB2 CAPN9 20479866 2263189 Our findings demonstrate that 4 is not *necessary* for [LFA-1] mediated adhesion , conjugation or migration . Positive_regulation ITGB2 CCL1 21976223 2512769 Importantly , directly *regulated* the expression of [CD18] and CD49b and hence influenced the adhesion capacity of human macrophages . Positive_regulation ITGB2 CCL11 9561923 500538 *increases* the expression of [CD11b/CD18] and adhesion properties in IL5 , but not fMLP prestimulated human peripheral blood eosinophils . Positive_regulation ITGB2 CCL2 10198043 605001 In contrast , staining for an activation epitope revealed a rapid and transient *up-regulation* of [LFA-1] activity by in monocytes and Jurkat CCR2 chemokine receptor transfectants or by stromal derived factor-1alpha in Jurkat cells . Positive_regulation ITGB2 CCNC 9152024 430996 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 CCR7 22117043 2541379 Hence , 2 independent ADAP/SKAP55 modules are essential components of the signaling machinery that regulates affinity and avidity of [LFA-1] in *response* to . Positive_regulation ITGB2 CD2 3093887 63416 and ( 2 ) suggest that and LFA-3 are *involved* in one pathway and [LFA-1] in another . Positive_regulation ITGB2 CD2 7608563 311950 Stimulation of neutrophils with CBR *induces* binding to ICAM-1 through activation of both [LFA-1] and Mac-1 . Positive_regulation ITGB2 CD2 7608563 311953 *Activation* of [Mac-1] by CBR was further confirmed by stimulation of neutrophil binding to fibrinogen , a ligand for Mac-1 . Positive_regulation ITGB2 CD2 7915956 243848 Moreover , entry of extracellular Ca2+ via Ca-channels is involved in both the CD3- and MHC class II , as well as part of the *induced* [LFA-1] activation . Positive_regulation ITGB2 CD2 8603434 352182 Analysis of expression of other adhesion molecules demonstrated that CD11a , [CD18] , CD44 , CD45 , CD48 , CD54 , and CD62L were significantly *increased* by either or anti-CD3 mAbs while the combination was not synergistic . Positive_regulation ITGB2 CD2 8821628 344560 Expression of other integrin , selectin , or immunoglobulin superfamily molecules ( CD11a , [CD18] , CD44 , CD45 , CD48 , CD54 and CD62L ) were all significantly *increased* by or anti-CD3 mAbs . Positive_regulation ITGB2 CD2 9574521 502481 Our results demonstrate that *activation* of [LFA-1] binding to ICAM-1 by CBR , in contrast to inside-out signaling mechanisms , does not require protein kinase C activation or protein phosphatase 2A activity nor is it affected by agents that interfere with reorganization of the cytoskeleton . Positive_regulation ITGB2 CD4 8207199 261369 [LFA-1] mediated antigen independent T cell adhesion is *regulated* by and p56lck tyrosine kinase . Positive_regulation ITGB2 CD4 8943387 400016 It was also shown , using different inhibitors of the PI3-kinase ( wortmannin , Ly294002 , and antisense oligonucleotides ) , that this lipid kinase was necessary for the down-regulation of [LFA-1] mediated adhesion *induced* by binding . Positive_regulation ITGB2 CD40 9550383 477773 In contrast , the expression of the PKA-R ( G324D ) subunit has no effect on *mediated* growth inhibition in M12 cells , nor on CD40 mediated induction of B7-1 , CD23 , Fas , ICAM-1 , or [LFA-1] . Positive_regulation ITGB2 CD40LG 21330348 2420245 Inhibition of *reduced* CLP induced up-regulation of [Mac-1] on neutrophils . Positive_regulation ITGB2 CD44 15749731 1383169 Our data demonstrate that ligation of *induces* phenotypic changes , cytoskeletal rearrangements and redistribution of PKC isoforms beta and delta , resulting in cell migration , as previously described for the cell surface receptor , [LFA-1] . Positive_regulation ITGB2 CD58 3093887 63417 and ( 2 ) suggest that CD2 and are *involved* in one pathway and [LFA-1] in another . Positive_regulation ITGB2 CD63 9824771 549162 CD10 , CD11b , CD11c , CD13 , [CD18] , CD35 , CD45 , CD66acde , and CD66b were upregulated at 15 min and remained upregulated at 180 min . CD61 and *increased* slightly at 15 min and returned to baseline by 180 min . CD16 and CD62L were down regulated at 15 min and normalized by 180 min. CD15s , CDw17 , CD32 , and CD44 were slightly down regulated at 15 min and then returned to baseline by 180 min . CD11a , CD15 , CD24 , CD31 , and CDw65 did not change during dialysis . Positive_regulation ITGB2 CD8A 20805505 2318282 Furthermore , PYK2 is essential for LFA-1 mediated T-cell adhesion and [LFA-1] *costimulation* of CD8 T-cell migration . Positive_regulation ITGB2 CD8B 20805505 2318283 Furthermore , PYK2 is essential for LFA-1 mediated T-cell adhesion and [LFA-1] *costimulation* of CD8 T-cell migration . Positive_regulation ITGB2 CD99 9278313 450945 Overexpression of the minor truncated form of markedly *down-regulated* the expression of [LFA-1] . Positive_regulation ITGB2 CDC42 11254681 794079 Stromal cell derived factor-1 induced [LFA-1] activation during in vivo migration of T cell hybridoma cells *requires* Gq/11 , RhoA , and myosin , as well as Gi and . Positive_regulation ITGB2 CDC42 11254681 794093 We show here that zeta associated protein 70-induced [LFA-1] activation *requires* neither and RhoA nor contraction and is thus quite different from that induced by SDF-1 . Positive_regulation ITGB2 CDC73 1362329 208090 Neither dose of phalloidin altered the upregulation of neutrophil membrane [CD11/CD18] glycoprotein adherence complex *induced* by or LTB4 . Positive_regulation ITGB2 CDC73 7531948 291984 Butanol and PTX also significantly reduced the *upregulation* of [CD11b/CD18] by f-methionyl-leucyl-phenylalanine ( fMLP ) and but not by phorbol myristate acetate ( PMA ) . Positive_regulation ITGB2 CDC73 7686761 222296 ( 10 ( -7 ) M ) *caused* a 42.8 +/- 5.7 % ( mean +/- SEM ) increase in [Mac-1] expression in eosinophils ( P < 0.01 ) and a 34.6 +/- 9.2 % increase in Mac-1 expression in neutrophils ( P < 0.05 ) . Positive_regulation ITGB2 CDC73 8047994 267084 also *enhanced* [CD18] expression ( 6.1 +/- 1.1 mean fluorescence intensity versus 10.3 +/- 2.3 ) , but beta-adrenoreceptor stimulation ( 10.1 +/- 2.1 ) and AC activation ( 9.7 +/- 1.9 ) had no discernible effect . Positive_regulation ITGB2 CDC73 9227560 443316 Pretreatment of neutrophils with SNAP or 8-bromoguanosine 3',5'-cyclic monophosphate did not reduce *induced* [CD11b/CD18] expression determined by flow cytometry , nor did simultaneous treatment of myocytes with IL-1 beta and SNAP decrease IL-1 beta induced intercellular adhesion molecule-1 expression determined by immunofluorescence staining and enzyme linked immunosorbent assay . Positive_regulation ITGB2 CDC73 9335316 457999 *up-regulated* the expression of [CDllb/CD18] , down-regulated L-selectin , and also increased F-actin assembly in eosinophils . Positive_regulation ITGB2 CDC73 9523024 493890 Coincubation of neutrophils with alpha-Toc and pretreatment of HUVEC with alpha-Toc significantly reduced *induced* [CD11b/CD18] expression and IL-1 beta induced upregulation of ICAM-1 and VCAM-1 , respectively . Positive_regulation ITGB2 CDK19 9152024 431001 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 CDK8 9152024 430999 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 CLEC7A 22177564 2518365 The ß-glucan receptor *activates* the [integrin Mac-1] in neutrophils via Vav protein signaling to promote Candida albicans clearance . Positive_regulation ITGB2 CPB1 8105757 231418 *caused* an immediate and sustained increase in the neutrophil CD11b and [CD18] expression in both groups ; Positive_regulation ITGB2 CPB2 8105757 231419 *caused* an immediate and sustained increase in the neutrophil CD11b and [CD18] expression in both groups ; Positive_regulation ITGB2 CR1 16600024 1556431 F-met-leu-phe *increased* CD11b , CD35 and [CD18] and decreased CD62L expression in all groups , with a greater increase in severe asthma . Positive_regulation ITGB2 CRH 16424794 1515682 *induced* a significant time- and concentration dependent increase of cell adhesion as well as monocytic [MAC-1] expression ; Positive_regulation ITGB2 CRK 20421794 2256525 This decrease in MAPK activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Positive_regulation ITGB2 CSDE1 12485937 1032967 We hypothesize that a -- an enhanceosome -- that includes GABP , other transcription factors , and coactivators , dynamically *regulates* [CD18] expression in myeloid cells . Positive_regulation ITGB2 CSF2 10718988 676919 Preincubation of the cells with different concentrations of budesonide was also effective in down regulating the C5a induced ICAM-1 expression on HBECs and the ah-CD23 and *induced* [LFA-1] and Mac-1 expression on eosinophils . Positive_regulation ITGB2 CSF2 12010822 941320 Flow cytometry showed that hu14.18 with or without GM-CSF and hu14.18/GM-CSF all mediated Mac-1 dependent PMN-target cell conjugate formation but that was *required* for the highest expression and activation of [Mac-1] , as evidenced by the mAb24 defined beta ( 2 ) -integrin activation epitope . Positive_regulation ITGB2 CSF2 12600815 1099029 IL-3 , IL-5 , and could enhance p38 MAPK and NF-kappaB activity and *induce* ICAM-1 , CD11b , and [CD18] expressions on eosinophils . Positive_regulation ITGB2 CSF2 1347707 182650 Granulocyte-macrophage ( GM-CSF ) significantly *increased* the expression of CD11b , CD11c , and [CD18] on normal PMN , decreased the expression of Fc receptors ( FcR ) , and enhanced ADCC by normal but not by LAD PMN . Positive_regulation ITGB2 CSF2 1355672 195835 Granulocyte-macrophage colony stimulating factor ( ) *causes* upregulation of neutrophil surface [CD11b/CD18] expression , and enhances the adhesion of neutrophils to cultured human endothelial cells in vitro . Positive_regulation ITGB2 CSF2 15710475 1373505 Using the markers Mac1 ( + ) /CD45 ( low ) and Mac1 ( + ) /CD45 ( high ) to define microglia and macrophages , respectively , we show that [Mac1] ( + ) cells are *induced* by stimulation following neuronal differentiation of mouse ES cells using a five-step method . Positive_regulation ITGB2 CSF2 2428876 62856 stimulation of HL-60 cells *induced* a similar [Mac-1] and p150 ,95 phenotype . Positive_regulation ITGB2 CSF2 7829234 293437 *augmented* the surface expression of ICAM-I and [CD18] in TAM and in blood monocytes . Positive_regulation ITGB2 CSF3 8757506 374706 , like GM-CSF , *increased* surface levels of the adhesive receptor , [CD11b/CD18] , but down-regulated L-selectin expression on neutrophils . Positive_regulation ITGB2 CSK 22496642 2583705 Moreover , coactivation of the Mincle and TLR2 pathways by TDM and treatment synergistically *induced* [CD11b/CD18] surface expression , reactive oxygen species , and TNFa production by neutrophils . Positive_regulation ITGB2 CSRP1 11673552 872866 Furthermore , mCRP , but not , *up-regulated* [CD11b/CD18] expression and stimulated neutrophil extracellular signal regulated kinase activity , which was accompanied by activation of p21(ras) oncoprotein , Raf-1 , and mitogen activated protein kinase kinase . Positive_regulation ITGB2 CTR9 1362329 208091 Neither dose of phalloidin altered the upregulation of neutrophil membrane [CD11/CD18] glycoprotein adherence complex *induced* by or LTB4 . Positive_regulation ITGB2 CTR9 7531948 291985 Butanol and PTX also significantly reduced the *upregulation* of [CD11b/CD18] by f-methionyl-leucyl-phenylalanine ( fMLP ) and but not by phorbol myristate acetate ( PMA ) . Positive_regulation ITGB2 CTR9 7686761 222297 ( 10 ( -7 ) M ) *caused* a 42.8 +/- 5.7 % ( mean +/- SEM ) increase in [Mac-1] expression in eosinophils ( P < 0.01 ) and a 34.6 +/- 9.2 % increase in Mac-1 expression in neutrophils ( P < 0.05 ) . Positive_regulation ITGB2 CTR9 8047994 267085 also *enhanced* [CD18] expression ( 6.1 +/- 1.1 mean fluorescence intensity versus 10.3 +/- 2.3 ) , but beta-adrenoreceptor stimulation ( 10.1 +/- 2.1 ) and AC activation ( 9.7 +/- 1.9 ) had no discernible effect . Positive_regulation ITGB2 CTR9 9227560 443317 Pretreatment of neutrophils with SNAP or 8-bromoguanosine 3',5'-cyclic monophosphate did not reduce *induced* [CD11b/CD18] expression determined by flow cytometry , nor did simultaneous treatment of myocytes with IL-1 beta and SNAP decrease IL-1 beta induced intercellular adhesion molecule-1 expression determined by immunofluorescence staining and enzyme linked immunosorbent assay . Positive_regulation ITGB2 CTR9 9335316 458000 *up-regulated* the expression of [CDllb/CD18] , down-regulated L-selectin , and also increased F-actin assembly in eosinophils . Positive_regulation ITGB2 CTR9 9523024 493891 Coincubation of neutrophils with alpha-Toc and pretreatment of HUVEC with alpha-Toc significantly reduced *induced* [CD11b/CD18] expression and IL-1 beta induced upregulation of ICAM-1 and VCAM-1 , respectively . Positive_regulation ITGB2 CTSB 17676580 1842389 Western blot analysis using a CD18 antibody targeted against the intracellular domain revealed reduced levels of full-length [CD18] after stimulation of neutrophils with either fluid shear stress or with the Ca2+ ionophore phorbol 12-myristate 13-acetate ( PMA ; 100 nM ) in the *presence* of exogenous ( 0.5 U/ml ) . Positive_regulation ITGB2 CTSZ 18194276 1895312 On the other hand , co-localization of cathepsin X and LFA-1 supports the *role* of in regulating [LFA-1] activity , which enhances lymphocyte proliferation . Positive_regulation ITGB2 CTSZ 18194276 1895314 As shown by fluorescence resonance energy transfer , using U-937 and Jurkat cells transfected with alpha ( L ) -mCFP and beta2-mYFP , recombinant directly *activates* [LFA-1] . Positive_regulation ITGB2 CXCL1 23460610 2781860 Accordingly , *mediated* induction of high-affinity [LFA-1] required HPK1 , but macrophage antigen 1 (Mac-1) affinity regulation was independent of HPK1 . Positive_regulation ITGB2 CXCL12 11254681 794078 induced [LFA-1] *activation* during in vivo migration of T cell hybridoma cells requires Gq/11 , RhoA , and myosin , as well as Gi and Cdc42 . Positive_regulation ITGB2 CXCL12 11598192 870527 *triggered* a transient regulation of adhesion to intercellular adhesion molecule-1 ( ICAM-1 ) and vascular cell adhesion molecule-1 mediated by lymphocyte function antigen-1 (LFA-1) and very late antigen-4 (VLA-4) , respectively , and a rapid increase in [LFA-1] binding to soluble ICAM-1 . Positive_regulation ITGB2 CXCL12 18195072 1857046 Here , we show that nonmuscle myosin heavy chain IIA ( MyH9 ) is recruited to LFA-1 at the uropod of migrating T lymphocytes , and inhibition of the association of MyH9 with LFA-1 results in extreme uropod elongation , defective tail detachment , and decreased lymphocyte migration on ICAM-1 , without affecting [LFA-1] *activation* by chemokine . Positive_regulation ITGB2 CXCL12 19934331 2172254 Specifically , RhoA and phospholipase D1 were crucially involved in [LFA-1] affinity *triggering* by in all analyzed patients . Positive_regulation ITGB2 CXCL12 21850266 2468776 These results suggested that HK-2 cells stimulated with TGF-ß ( 1 ) induced conformational *activation* of [LFA-1] on PBMCs by increased . Positive_regulation ITGB2 CXCL9 18292502 1872925 However , the inflammatory chemokine *triggered* robust [LFA-1] mediated T lymphocyte adhesion to ICAM-1 at subsecond contacts independently of the RhoA 23/40 region . Positive_regulation ITGB2 CYTH1 10835351 697835 Thus , is *involved* in the activation of [LFA-1] , most probably through direct interaction with the integrin , and induces cell spreading by its ARF-GEF activity . Positive_regulation ITGB2 DAP 24295830 2926699 Moreover , IL-32? and or MDP *induced* the significant up-regulation of the cell-surface expression of adhesion molecule [CD18] and ICAM-1 on eosinophils . Positive_regulation ITGB2 DST 14555285 1153103 At low concentrations ( 10 ( -10 ) -10 ( -8 ) M ) , significantly increased the superoxide production by differentiated HL-60 cells stimulated with opsonized zymosan ( OZ ) by about 20 % , and expression of [CD18] , a component of the OZ-receptor , was *increased* to a similar extent by 10 ( -9 ) M BPA . Positive_regulation ITGB2 DYNLRB1 11386619 821714 Up-regulation of PMN [Mac-1] in *response* to occurred independently of membrane bound CD14 (mCD14) . Positive_regulation ITGB2 EDN1 11877323 919038 2 . rapidly down-regulated the expression of L-selectin and *up-regulated* the expression of [CD11b/CD18] on the neutrophil surface . Positive_regulation ITGB2 EDN1 8872951 389787 In further in vitro studies , we found that *induced* the expression of the [CD18] antigens on the neutrophil surface . Positive_regulation ITGB2 ELANE 17024574 1647900 The inhibitor significantly *reduces* ICAM-1 expression and [Mac-1] ( + ) cell accumulation in ischemic liver lobes after reperfusion . Positive_regulation ITGB2 EML1 9808058 545021 Similar to HL60 , MPRO and *induce* expression of [CD11b/CD18] and also exhibit downregulation of CD34 on differentiation . Positive_regulation ITGB2 EML2 9808058 545018 Similar to HL60 , MPRO and *induce* expression of [CD11b/CD18] and also exhibit downregulation of CD34 on differentiation . Positive_regulation ITGB2 EML3 9808058 545020 Similar to HL60 , MPRO and *induce* expression of [CD11b/CD18] and also exhibit downregulation of CD34 on differentiation . Positive_regulation ITGB2 EML4 9808058 545017 Similar to HL60 , MPRO and *induce* expression of [CD11b/CD18] and also exhibit downregulation of CD34 on differentiation . Positive_regulation ITGB2 EML5 9808058 545019 Similar to HL60 , MPRO and *induce* expression of [CD11b/CD18] and also exhibit downregulation of CD34 on differentiation . Positive_regulation ITGB2 EML6 9808058 545022 Similar to HL60 , MPRO and *induce* expression of [CD11b/CD18] and also exhibit downregulation of CD34 on differentiation . Positive_regulation ITGB2 EPX 18555090 1923895 [Integrin-beta] was down-regulated and CdK4 expression was *increased* significantly with . Positive_regulation ITGB2 ETS1 15940256 1440473 In correlation with these results , upregulation *increases* [integrinbeta2] expression but not that of other integrins . Positive_regulation ITGB2 FCGR2A 9378982 465714 Engagement of either or Fc gamma RIIIb *leads* to activation , demonstrated by degranulation ( upregulation of CD66b ) , and to increased expression of total [CD11b/CD18] and functional CD11b/CD18 ( I-domain ) . Positive_regulation ITGB2 FCGR3B 9378982 465715 Engagement of either Fc gamma RIIa or *leads* to activation , demonstrated by degranulation ( upregulation of CD66b ) , and to increased expression of total [CD11b/CD18] and functional CD11b/CD18 ( I-domain ) . Positive_regulation ITGB2 FOXP3 12209514 983976 Under the same conditions , 200 of UV light *enhanced* the [MFI 7-fold] . Positive_regulation ITGB2 GAL 11050049 743322 In addition , *caused* up-regulation of [Mac-1] ( CD11b/CD18 ) and shedding of L-selectin from circulating neutrophils . Positive_regulation ITGB2 GAL 7768509 308392 however , only also *caused* upregulation of [Mac-1] on circulating neutrophils and liver injury . Positive_regulation ITGB2 GFAP 18823368 1981535 The expression of [Mac-1] increased 1 day after MDMA treatment and *increased* 3 days post-treatment in the striatum and SN but not in the NAc , in strict anatomical correlation with dopaminergic damage . Positive_regulation ITGB2 GPI 11818440 908178 Cross linking of , a possible regulatory molecule of cell adhesion , *induces* up-regulation of [CD11b/CD18] expression on neutrophil surfaces and shedding of L-selectin . Positive_regulation ITGB2 GPI 11818440 908180 cross linking *induced* up-regulation of [CD11b/CD18] ( Mac-1 ) expression on neutrophil surfaces and shedding of L-selectin , which depends on tyrosine phosphorylation and cytoskeleton remodeling . Positive_regulation ITGB2 HMGB1 17268551 1697072 In vitro , *enhanced* the interaction between [Mac-1] and RAGE . Positive_regulation ITGB2 HMGB1 17268551 1697075 Moreover , induced activation of nuclear factor-kappaB in neutrophils *required* both [Mac-1] and RAGE . Positive_regulation ITGB2 HNRNPD 12485937 1032968 We hypothesize that a -- an enhanceosome -- that includes GABP , other transcription factors , and coactivators , dynamically *regulates* [CD18] expression in myeloid cells . Positive_regulation ITGB2 ICAM1 11442273 833497 The aim of this study is to examine the binding and internalization mechanisms of [LFA-1] peptide [ cLAB.L or cyclo- ( 1,12 ) -PenITDGEATDSGC ] *mediated* by receptors on the surface of lymphocytes . Positive_regulation ITGB2 ICAM1 11466362 839933 Binding of a novel CD18 activation epitope mAb to [LFA-1] in *response* to soluble binding was also blocked by inhibitory and was enhanced by activating IDAS mutations . Positive_regulation ITGB2 ICAM1 1362459 208101 It is modulated both by regulation of expression and by *activation* of [LFA-1] molecules constitutively expressed on leukocyte membranes . Positive_regulation ITGB2 ICAM1 20805842 2401413 We further show that exposure of human DCs to the lymphoid chemokine CCL21 specifically restores the high-affinity form of [LFA-1] and *induces* binding to its ligand under low shear stress . Positive_regulation ITGB2 ICAM1 24314082 2880124 Between the two distinct populations of CD11b/CD18 : ICAM-1 complex that participate in cell adhesion , the cytoskeleton(CSK) anchored elastic elements and the membrane tethers , we found that LA1 *enhanced* binding of [CD11b/CD18] on K562 cells to ICAM-1 via the formation of long membrane tethers , whereas Mn ( 2+ ) additionally increased binding via CSK anchored bonds . Positive_regulation ITGB2 ICAM1 7608563 311951 Stimulation of neutrophils with CBR LFA-1/2 *induces* binding to through activation of both LFA-1 and [Mac-1] . Positive_regulation ITGB2 ICAM1 8450207 214132 In addition to previous defined roles for class II MHC Ag , *stimulation* of [LFA-1] on the T cells by on the keratinocytes also plays an important costimulatory role in this superantigen mediated response . Positive_regulation ITGB2 ICAM1 8829772 371501 These findings suggest that production is induced by endotoxins and cytokines produced in excess by inflammatory reactions and that endotoxins and cytokines are *involved* in qualitative , but not quantitative changes in [LFA-1] ( CD11a/CD18 ) and Mac-1 ( CD11b/CD18 ) . Positive_regulation ITGB2 ICAM1 8986235 404030 The present study further supports that [CD18/] *dependent* leukocyte-endothelial adhesive interactions lead to macromolecular leakage in the postcapillary venules exposed to ethanol . Positive_regulation ITGB2 ICAM1 9130650 426910 We have investigated the *role* of ligands ( and ICAM-3 ) in [LFA-1] activation by using ICAM blocking monoclonal antibodies and a fixation protocol for `` freezing '' LFA-1 on the surface of cells after prior exposure to ICAM-1 and ICAM-3 . Positive_regulation ITGB2 ICAM1 9523024 493871 PAF *induced* upregulation of CD11b and [CD18] on neutrophils and IL-1 beta increased surface expression of and VCAM-1 on HUVEC . Positive_regulation ITGB2 ICAM1 9753946 535186 FACS analysis demonstrated that ICAM-1 and [LFA-1] expression *increased* during EMIU , with expression higher than that of LFA-1 . Positive_regulation ITGB2 ICAM2 11442273 833498 The aim of this study is to examine the binding and internalization mechanisms of [LFA-1] peptide [ cLAB.L or cyclo- ( 1,12 ) -PenITDGEATDSGC ] *mediated* by receptors on the surface of lymphocytes . Positive_regulation ITGB2 ICAM2 7744962 306368 The peptide also *induces* [CD11b/CD18] and CD11c/CD18 mediated binding of THP-1 cells to fibrinogen and iC3b coated on plastic . Positive_regulation ITGB2 ICAM3 11442273 833499 The aim of this study is to examine the binding and internalization mechanisms of [LFA-1] peptide [ cLAB.L or cyclo- ( 1,12 ) -PenITDGEATDSGC ] *mediated* by receptors on the surface of lymphocytes . Positive_regulation ITGB2 ICAM3 9130650 426911 We have investigated the *role* of ligands ( ICAM-1 and ) in [LFA-1] activation by using ICAM blocking monoclonal antibodies and a fixation protocol for `` freezing '' LFA-1 on the surface of cells after prior exposure to ICAM-1 and ICAM-3 . Positive_regulation ITGB2 ICAM4 11442273 833500 The aim of this study is to examine the binding and internalization mechanisms of [LFA-1] peptide [ cLAB.L or cyclo- ( 1,12 ) -PenITDGEATDSGC ] *mediated* by receptors on the surface of lymphocytes . Positive_regulation ITGB2 ICAM5 11442273 833501 The aim of this study is to examine the binding and internalization mechanisms of [LFA-1] peptide [ cLAB.L or cyclo- ( 1,12 ) -PenITDGEATDSGC ] *mediated* by receptors on the surface of lymphocytes . Positive_regulation ITGB2 IFIT1 18056473 1833676 Although CD3 zeta is phosphorylated by conjugation in vitro with cognate tumor cells , showing that TIL are triggered , PLC gamma-1 , LAT , and ZAP70 are not activated and LFA-1 is not affinity matured , and because ( lck ) is *required* for [LFA-1] activation , this implies that the signaling blockade is very proximal . Positive_regulation ITGB2 IFNG 11896209 920863 Because IFN-gamma is an important cytokine during granulocytic ehrlichiosis and is known to activate leukocytes , we investigated the potential *role* of in [CD11b/CD18] up-regulation . Positive_regulation ITGB2 IFNG 1355014 195696 enhanced ICAM-1 expression but not LFA-1 expression , and PMA *augmented* both [LFA-1] and ICAM-1 expression . Positive_regulation ITGB2 IFNG 1355014 195698 These results collectively suggest that expression of [LFA-1] and ICAM-1 is regulated differently and that and PMA *regulate* the expression through different mechanisms . Positive_regulation ITGB2 IFNG 3923098 49076 Specifically , macrophage activating factor (MAF) , , or picogram amounts of endotoxin ( LPS ) *induced* [LFA-1] on TG-elicited macrophages following overnight incubation . Positive_regulation ITGB2 IL10 10536118 562876 Flow cytometric analysis of dispersed lung cells showed that expression of in the airway *reduced* the absolute number of Class II major histocompatibility complex ( MHC ) ( + ) /CD11c ( + ) ( dendritic cells ) and Class II MHC ( + ) [/Mac-1] ( bright ) ( macrophages ) cells expressing the costimulatory molecules B7.1 and B7.2 by 30 % . Positive_regulation ITGB2 IL15 10453029 637894 Pretreatment of T cells with rolipram or cAMP analogues inhibited the *stimulated* increases in proliferation , expression of cell surface molecules CD69 , ICAM-1 , and [LFA-1] , and release of TNF-alpha from macrophages . Positive_regulation ITGB2 IL15 11449367 836571 Furthermore , we also demonstrated that IL-2 , IL-7 and could *induce* de novo the synthesis of [LFA-1] and CD2 . Positive_regulation ITGB2 IL15 15996196 1430200 significantly *increased* neutrophil cell surface expression of CD11b and [CD18] and up-regulated A549 cell surface expression of CD54 . Positive_regulation ITGB2 IL1A 9698257 524881 and TNF-alpha differentially *regulate* CD4 and [Mac-1] expression in mouse microglia . Positive_regulation ITGB2 IL1B 12711326 1083270 To investigate whether TGZ acts by affecting the ICAM-1/LFA-1 pathway and/or the Th1/Th2 cytokine balance in NOD mice , we analysed the *induced* ICAM-1 expression on islet-cells and the [LFA-1] , CD25 , IL-2 , IFN-gamma , IL-4 , and IL-10 expression on splenocytes . Positive_regulation ITGB2 IL1B 17332440 1747959 Peptidoglycan ( PGN ) ( TLR2 ligand ) , flagellin ( TLR5 ligand ) , and Imiquimod R837 ( TLR7 ligand ) could significantly upregulate cell surface expression of intercellular adhesion molecule (ICAM)-1 and [CD18] , and *induce* the release of , IL-6 , IL-8 , growth related oncogene ( GRO ) -alpha , and superoxides of eosinophils . Positive_regulation ITGB2 IL1B 9197378 438551 In addition , pretreatment of infected monocytes with a TNF-alpha synthesis inhibitor , RP 55778 , or with MAbs directed against IL-1beta , confirmed the *role* of TNF-alpha and in the regulation of [CD18] , CD44 , and CD54 expression . Positive_regulation ITGB2 IL1B 9523024 493895 Coincubation of neutrophils with alpha-Toc and pretreatment of HUVEC with alpha-Toc significantly reduced PAF induced [CD11b/CD18] expression and induced *upregulation* of ICAM-1 and VCAM-1 , respectively . Positive_regulation ITGB2 IL2 1356917 198078 The mean fluorescence intensity ( MFI ) of monocyte CD11a was enhanced by interleukin-2 (IL-2) , TNF-alpha and TNF-beta , and that of CD11b , CD11c and [CD18] was *increased* by , IL-4 , TNF-alpha and TNF-beta . Positive_regulation ITGB2 IL2 2646377 108716 In contrast , *induced* cell proliferation , IL-2R expression , and [LFA-1] expression were enhanced by the addition of PMA . Positive_regulation ITGB2 IL2 7723403 301921 *upregulates* [LFA-1] expression on natural killer cells . Positive_regulation ITGB2 IL32 24295830 2926698 Moreover , and iE-DAP or MDP *induced* the significant up-regulation of the cell-surface expression of adhesion molecule [CD18] and ICAM-1 on eosinophils . Positive_regulation ITGB2 IL4 16001979 1447318 Surface expression of very late antigen-4 [ VLA-4 ] and [LFA-1] was decreased and the production of the type 2 cytokines IL-5 and IL-13 was *augmented* by the presence of during stimulation of CD8+ T cells from mild atopic asthmatics . Positive_regulation ITGB2 IL4 1901520 155821 LFA-1 is upregulated by IFN-gamma in Thyoglicolate- and bone marrow derived M phi and P388D1 cells , while does not *induce* [LFA-1] on these cells . Positive_regulation ITGB2 IL4 2547869 115654 *Induction* of [LFA-1] expression by was furthermore confirmed at the specific LFA-1 beta-chain mRNA level . Positive_regulation ITGB2 IL4 2547869 115655 was unable to *induce* [LFA-1] expression on EBV transformed lymphoblastoid cell lines of two LFA-1-deficient patients . Positive_regulation ITGB2 IL4 2547869 115657 BL2 grows as single cells , but *induction* of [LFA-1] and LFA-3 expression by was insufficient to induce homotypic cell adhesions and required PMA as a second signal . Positive_regulation ITGB2 IL5 12046991 950175 Olopatadine dose-dependently repressed the *induced* expressions of CD11a/CD18 ( LFA-1 ) and [CD11b/CD18] ( Mac-1 ) on rat peritoneal eosinophils . Positive_regulation ITGB2 IL6 7861762 296083 did not *increase* neutrophil [CD18] adhesion receptor expression . Positive_regulation ITGB2 IL7 11449367 836572 Furthermore , we also demonstrated that IL-2 , and IL-15 could *induce* de novo the synthesis of [LFA-1] and CD2 . Positive_regulation ITGB2 IL8 10095863 560674 Moreover , EM downregulated L-selectin expression and inhibited *induced* upregulation of [Mac-1] on peripheral blood neutrophils . Positive_regulation ITGB2 IL8 12167449 973119 Furthermore , the administration of CAM strongly inhibited the *induced* up-regulation of [Mac-1] expression on neutrophils . Positive_regulation ITGB2 IL8 17332440 1747960 Peptidoglycan ( PGN ) ( TLR2 ligand ) , flagellin ( TLR5 ligand ) , and Imiquimod R837 ( TLR7 ligand ) could significantly upregulate cell surface expression of intercellular adhesion molecule (ICAM)-1 and [CD18] , and *induce* the release of IL-1beta , IL-6 , , growth related oncogene ( GRO ) -alpha , and superoxides of eosinophils . Positive_regulation ITGB2 IL8 19086264 2003588 The objective of this study was to examine the role of protein kinase C zeta (PKCzeta) in *mediated* activation of [Mac-1] ( CD11b/CD18 ) in human neutrophils . Positive_regulation ITGB2 IL8 1969919 130899 *promoted* additional adhesive interactions between [CD11b/CD18] and the biosynthetic precursor of LPS , lipid IVa , fibrinogen , and endothelial cells , suggesting that NAP-1/IL-8 may promote leukocyte adhesion in vivo that could lead to recruitment of PMN to sites of tissue inflammation . Positive_regulation ITGB2 IL8 7514872 257085 In contrast , similar to previous studies , recombinant C5a , recombinant and FMLP all *stimulated* increased expression of [CD11b/CD18] ( 170-260 % of basal , P < 0.001 , n = 5 ) and shedding of L-selectin ( 56-75 % reduction from basal , P < 0.001 , n = 5 ) at similar concentrations and with similar potencies ( EC50 = 2 , 5 , and 3 nM respectively ) . Positive_regulation ITGB2 IL8 8711427 376627 The quantitative levels of [CD11b/CD18] , but not CD29 and CD61 , was *increased* by fMLP , but not RANTES nor . Positive_regulation ITGB2 IL8 9124560 424028 Detailed studies with IFN-gamma stimulated ( 100 U/ml ) C3A cells revealed that this adhesion involved [CD11a/CD18] [ lymphocyte function associated antigen-1 ( LFA-1 ) ] and CD54 and was *dependent* on low levels of produced by the stimulated hepatocytes . Positive_regulation ITGB2 IL8 9383570 466229 *Up-regulation* of neutrophil cell surface [Mac-1] expression by , arachidonic acid or tumour necrosis factor alpha leads to increased cell surface oligodeoxynucleotide binding and internalization . Positive_regulation ITGB2 INS 24915517 2952163 *induced* surface expression of [Mac-1] , and neutralization of Mac-1 blocked insulin induced adhesion of THP-1 as well as BDMCs . Positive_regulation ITGB2 ITGA1 16301335 1485094 Specific and beta chain phosphorylations *regulate* [LFA-1] activation through affinity dependent and -independent mechanisms . Positive_regulation ITGB2 ITGA10 16301335 1485095 Specific and beta chain phosphorylations *regulate* [LFA-1] activation through affinity dependent and -independent mechanisms . Positive_regulation ITGB2 ITGA11 16301335 1485096 Specific and beta chain phosphorylations *regulate* [LFA-1] activation through affinity dependent and -independent mechanisms . Positive_regulation ITGB2 ITGA2 16301335 1485097 Specific and beta chain phosphorylations *regulate* [LFA-1] activation through affinity dependent and -independent mechanisms . Positive_regulation ITGB2 ITGA3 16301335 1485098 Specific and beta chain phosphorylations *regulate* [LFA-1] activation through affinity dependent and -independent mechanisms . Positive_regulation ITGB2 ITGA4 10623819 658383 interaction *activates* [alpha L beta 2 integrin] mediated adhesion to ICAM-1 in human T cells . Positive_regulation ITGB2 ITGA4 11261794 794551 Thus , [LFA-1] mediates TEM under most conditions , but can also *mediate* TEM , although , in contrast to LFA-1 , this requires exogenous chemokines and EC activation . Positive_regulation ITGB2 ITGA4 16301335 1485099 Specific and beta chain phosphorylations *regulate* [LFA-1] activation through affinity dependent and -independent mechanisms . Positive_regulation ITGB2 ITGA4 7532681 292165 LFA-1 alone or alone is sufficient to mediate most of this migration , and either [LFA-1] or VLA-4 is *required* for monocyte migration to joint inflammation . Positive_regulation ITGB2 ITGA4 7759886 307849 3 ) Mac-1 plays a less important role than LFA-1 , as [LFA-1] appears to substitute for Mac-1 , and and LFA-1 can *mediate* much of the adhesion and migration . Positive_regulation ITGB2 ITGA5 16301335 1485100 Specific and beta chain phosphorylations *regulate* [LFA-1] activation through affinity dependent and -independent mechanisms . Positive_regulation ITGB2 ITGA6 16301335 1485101 Specific and beta chain phosphorylations *regulate* [LFA-1] activation through affinity dependent and -independent mechanisms . Positive_regulation ITGB2 ITGA7 16301335 1485102 Specific and beta chain phosphorylations *regulate* [LFA-1] activation through affinity dependent and -independent mechanisms . Positive_regulation ITGB2 ITGA8 16301335 1485103 Specific and beta chain phosphorylations *regulate* [LFA-1] activation through affinity dependent and -independent mechanisms . Positive_regulation ITGB2 ITGA9 16301335 1485104 Specific and beta chain phosphorylations *regulate* [LFA-1] activation through affinity dependent and -independent mechanisms . Positive_regulation ITGB2 ITGAL 12147632 970082 [LFA-1] may enhance co-stimulation , and both and CD62L are *involved* in T cell trafficking . Positive_regulation ITGB2 ITGAL 19750481 2175902 Cathepsin X cleaves the beta2 cytoplasmic tail of [LFA-1] *inducing* the intermediate affinity form of and alpha-actinin-1 binding . Positive_regulation ITGB2 ITGAL 2978519 104117 [LFA-1] mediates the binding of killer T cells to targets , CR3 mediates binding of phagocytes to iC3b coated surfaces and to endothelial cells , and , CR3 , and p150 ,95 each *mediate* the binding of bacterial lipopolysaccharide . Positive_regulation ITGB2 ITGAL 3156928 46756 Intracellularly , and Mo1 ( OKM1 ) were detectable and [LFA-1] expression was *enhanced* on patient T cells stimulated with phytohemagglutinin . Positive_regulation ITGB2 ITGAL 7759886 307850 3 ) Mac-1 plays a less important role than LFA-1 , as [LFA-1] appears to substitute for Mac-1 , and VLA-4 and can *mediate* much of the adhesion and migration . Positive_regulation ITGB2 ITGAL 8620558 359393 Whereas was increased only on monocytes , CD11b , CD11c , and [CD18] were strongly *enhanced* on monocytes and polymorphonuclear cells ( PMNs ) after treatment with MDPs . Positive_regulation ITGB2 ITGAM 18055569 1867370 Taken together , these observations suggest that activation *causes* translocation of [CD11b/CD18] into Lyn coupled , LacCer enriched lipid rafts , allowing neutrophils to phagocytose NOZs via CD11b/CD18 . Positive_regulation ITGB2 ITGAM 9242371 446010 In vitro , both immunoglobulin A and immunoglobulin G2a CD3 mAbs *induce* immediate activation of [CD11a/CD18] , with concomitant up-regulation of on T cells , each of which is shown to be involved in the concurrent adhesion of T cells to endothelium . Positive_regulation ITGB2 ITGB1 10623819 658384 interaction *activates* [alpha L beta 2 integrin] mediated adhesion to ICAM-1 in human T cells . Positive_regulation ITGB2 ITGB1 11261794 794552 Thus , [LFA-1] mediates TEM under most conditions , but can also *mediate* TEM , although , in contrast to LFA-1 , this requires exogenous chemokines and EC activation . Positive_regulation ITGB2 ITGB1 7532681 292166 [LFA-1] alone or VLA-4 alone is sufficient to mediate most of this migration , and either LFA-1 or is *required* for monocyte migration to joint inflammation . Positive_regulation ITGB2 ITGB1 7759886 307851 3 ) Mac-1 plays a less important role than LFA-1 , as [LFA-1] appears to substitute for Mac-1 , and and LFA-1 can *mediate* much of the adhesion and migration . Positive_regulation ITGB2 ITGB3 9824771 549163 CD10 , CD11b , CD11c , CD13 , [CD18] , CD35 , CD45 , CD66acde , and CD66b were upregulated at 15 min and remained upregulated at 180 min . and CD63 *increased* slightly at 15 min and returned to baseline by 180 min . CD16 and CD62L were down regulated at 15 min and normalized by 180 min. CD15s , CDw17 , CD32 , and CD44 were slightly down regulated at 15 min and then returned to baseline by 180 min . CD11a , CD15 , CD24 , CD31 , and CDw65 did not change during dialysis . Positive_regulation ITGB2 ITIH4 21850260 2468768 HIV envelope *activates* [LFA-1] on CD4 T-lymphocytes and increases cell susceptibility to LFA-1 targeting leukotoxin ( LtxA ) . Positive_regulation ITGB2 ITIH4 21850260 2468769 The data show that HIV-1 was *sufficient* to trigger [LFA-1] activation in fully quiescent naïve CD4 T cells in a CD4 dependent manner , and these CD4 T cells became more susceptible to killing by LtxA , a bacterial leukotoxin that preferentially targets leukocytes expressing high levels of the active LFA-1 . Positive_regulation ITGB2 KLRAP1 17237371 1689821 Activating receptors *regulate* [LFA-1] mediated adhesion by NK cells . Positive_regulation ITGB2 LCP1 21805466 2495239 Thus , expression of nonphosphorylatable in untransformed human peripheral blood T cells *leads* to reduced accumulation of [LFA-1] in the immune synapse and to a diminished F-actin increase upon T-cell activation . Positive_regulation ITGB2 LDLR 9824512 553523 In conclusion , macrophages stimulated with LPS synthesize more IL-1alpha and IL-1beta than controls and this phenomenon is *mediated* by the [CD11c/CD18] receptor . Positive_regulation ITGB2 LEO1 1362329 208094 Neither dose of phalloidin altered the upregulation of neutrophil membrane [CD11/CD18] glycoprotein adherence complex *induced* by or LTB4 . Positive_regulation ITGB2 LEO1 7531948 291988 Butanol and PTX also significantly reduced the *upregulation* of [CD11b/CD18] by f-methionyl-leucyl-phenylalanine ( fMLP ) and but not by phorbol myristate acetate ( PMA ) . Positive_regulation ITGB2 LEO1 7686761 222300 ( 10 ( -7 ) M ) *caused* a 42.8 +/- 5.7 % ( mean +/- SEM ) increase in [Mac-1] expression in eosinophils ( P < 0.01 ) and a 34.6 +/- 9.2 % increase in Mac-1 expression in neutrophils ( P < 0.05 ) . Positive_regulation ITGB2 LEO1 8047994 267088 also *enhanced* [CD18] expression ( 6.1 +/- 1.1 mean fluorescence intensity versus 10.3 +/- 2.3 ) , but beta-adrenoreceptor stimulation ( 10.1 +/- 2.1 ) and AC activation ( 9.7 +/- 1.9 ) had no discernible effect . Positive_regulation ITGB2 LEO1 9227560 443320 Pretreatment of neutrophils with SNAP or 8-bromoguanosine 3',5'-cyclic monophosphate did not reduce *induced* [CD11b/CD18] expression determined by flow cytometry , nor did simultaneous treatment of myocytes with IL-1 beta and SNAP decrease IL-1 beta induced intercellular adhesion molecule-1 expression determined by immunofluorescence staining and enzyme linked immunosorbent assay . Positive_regulation ITGB2 LEO1 9335316 458003 *up-regulated* the expression of [CDllb/CD18] , down-regulated L-selectin , and also increased F-actin assembly in eosinophils . Positive_regulation ITGB2 LEO1 9523024 493894 Coincubation of neutrophils with alpha-Toc and pretreatment of HUVEC with alpha-Toc significantly reduced *induced* [CD11b/CD18] expression and IL-1 beta induced upregulation of ICAM-1 and VCAM-1 , respectively . Positive_regulation ITGB2 LPA 16403785 1527139 Through its interaction with [Mac-1] , *induced* activation of the proinflammatory transcription factor NFkappaB , as well as the NFkappaB related expression of prothrombotic tissue factor . Positive_regulation ITGB2 LPA 8782841 380482 Oxidized *induces* cell adhesion molecule [Mac-1] ( CD 11b ) and enhances adhesion of the monocytic cell line U937 to cultured endothelial cells . Positive_regulation ITGB2 LTA 1356917 198079 The mean fluorescence intensity ( MFI ) of monocyte CD11a was enhanced by interleukin-2 (IL-2) , TNF-alpha and TNF-beta , and that of CD11b , CD11c and [CD18] was *increased* by IL-2 , IL-4 , TNF-alpha and . Positive_regulation ITGB2 LTB 1362329 208095 Neither dose of phalloidin altered the upregulation of neutrophil membrane [CD11/CD18] glycoprotein adherence complex *induced* by PAF or . Positive_regulation ITGB2 LTB 1677155 163238 The data indicate that Tx-induced diapedesis is mediated by the generation of and the *activation* of neutrophil [CD 18] but not endothelial adhesion proteins . Positive_regulation ITGB2 LTB 9491823 489699 As an indication of LTB4 receptor antagonism following oral administration of CP-105,696 , the inhibiton of *induced* upregulation of the neutrophil cell surface complement receptor ( CR3 ) , [CD11b/CD18] , was monitored at 4 h following drug administration using an ex vivo whole blood flow cytometry assay . Positive_regulation ITGB2 MAF 3923098 49077 Specifically , , interferon-gamma (IFN-gamma) , or picogram amounts of endotoxin ( LPS ) *induced* [LFA-1] on TG-elicited macrophages following overnight incubation . Positive_regulation ITGB2 MAP4K1 23460610 2781861 Accordingly , CXCL1 mediated induction of high-affinity [LFA-1] *required* , but macrophage antigen 1 (Mac-1) affinity regulation was independent of HPK1 . Positive_regulation ITGB2 MAPK1 11121138 758444 Inhibition of the activity *caused* growth inhibition of the [Mac-1] , Mac-2 A , and JK cell lines . Positive_regulation ITGB2 MAPK1 11529937 853710 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Positive_regulation ITGB2 MAPK1 12600815 1099031 IL-3 , IL-5 , and GM-CSF could enhance p38 and NF-kappaB activity and *induce* ICAM-1 , CD11b , and [CD18] expressions on eosinophils . Positive_regulation ITGB2 MAPK1 20421794 2256527 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Positive_regulation ITGB2 MAPK1 23935932 2826750 Adiponectin inhibits neutrophil phagocytosis of Escherichia coli by inhibition of PKB and ERK 1/2 signalling and [Mac-1] *activation* . Positive_regulation ITGB2 MAPK10 11121138 758445 Inhibition of the activity *caused* growth inhibition of the [Mac-1] , Mac-2 A , and JK cell lines . Positive_regulation ITGB2 MAPK10 11529937 853711 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Positive_regulation ITGB2 MAPK10 12600815 1099032 IL-3 , IL-5 , and GM-CSF could enhance p38 and NF-kappaB activity and *induce* ICAM-1 , CD11b , and [CD18] expressions on eosinophils . Positive_regulation ITGB2 MAPK10 20421794 2256528 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Positive_regulation ITGB2 MAPK10 23935932 2826751 Adiponectin inhibits neutrophil phagocytosis of Escherichia coli by inhibition of PKB and ERK 1/2 signalling and [Mac-1] *activation* . Positive_regulation ITGB2 MAPK11 11121138 758446 Inhibition of the activity *caused* growth inhibition of the [Mac-1] , Mac-2 A , and JK cell lines . Positive_regulation ITGB2 MAPK11 11529937 853712 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Positive_regulation ITGB2 MAPK11 12600815 1099033 IL-3 , IL-5 , and GM-CSF could enhance p38 and NF-kappaB activity and *induce* ICAM-1 , CD11b , and [CD18] expressions on eosinophils . Positive_regulation ITGB2 MAPK11 20421794 2256529 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Positive_regulation ITGB2 MAPK11 23935932 2826752 Adiponectin inhibits neutrophil phagocytosis of Escherichia coli by inhibition of PKB and ERK 1/2 signalling and [Mac-1] *activation* . Positive_regulation ITGB2 MAPK12 11121138 758447 Inhibition of the activity *caused* growth inhibition of the [Mac-1] , Mac-2 A , and JK cell lines . Positive_regulation ITGB2 MAPK12 11529937 853713 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Positive_regulation ITGB2 MAPK12 12600815 1099034 IL-3 , IL-5 , and GM-CSF could enhance p38 and NF-kappaB activity and *induce* ICAM-1 , CD11b , and [CD18] expressions on eosinophils . Positive_regulation ITGB2 MAPK12 20421794 2256530 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Positive_regulation ITGB2 MAPK12 23935932 2826753 Adiponectin inhibits neutrophil phagocytosis of Escherichia coli by inhibition of PKB and ERK 1/2 signalling and [Mac-1] *activation* . Positive_regulation ITGB2 MAPK13 11121138 758448 Inhibition of the activity *caused* growth inhibition of the [Mac-1] , Mac-2 A , and JK cell lines . Positive_regulation ITGB2 MAPK13 11529937 853714 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Positive_regulation ITGB2 MAPK13 12600815 1099035 IL-3 , IL-5 , and GM-CSF could enhance p38 and NF-kappaB activity and *induce* ICAM-1 , CD11b , and [CD18] expressions on eosinophils . Positive_regulation ITGB2 MAPK13 20421794 2256531 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Positive_regulation ITGB2 MAPK13 23935932 2826754 Adiponectin inhibits neutrophil phagocytosis of Escherichia coli by inhibition of PKB and ERK 1/2 signalling and [Mac-1] *activation* . Positive_regulation ITGB2 MAPK14 11121138 758449 Inhibition of the activity *caused* growth inhibition of the [Mac-1] , Mac-2 A , and JK cell lines . Positive_regulation ITGB2 MAPK14 11529937 853715 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Positive_regulation ITGB2 MAPK14 12600815 1099036 IL-3 , IL-5 , and GM-CSF could enhance p38 and NF-kappaB activity and *induce* ICAM-1 , CD11b , and [CD18] expressions on eosinophils . Positive_regulation ITGB2 MAPK14 20421794 2256532 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Positive_regulation ITGB2 MAPK14 23935932 2826755 Adiponectin inhibits neutrophil phagocytosis of Escherichia coli by inhibition of PKB and ERK 1/2 signalling and [Mac-1] *activation* . Positive_regulation ITGB2 MAPK15 11121138 758443 Inhibition of the activity *caused* growth inhibition of the [Mac-1] , Mac-2 A , and JK cell lines . Positive_regulation ITGB2 MAPK15 11529937 853709 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Positive_regulation ITGB2 MAPK15 12600815 1099030 IL-3 , IL-5 , and GM-CSF could enhance p38 and NF-kappaB activity and *induce* ICAM-1 , CD11b , and [CD18] expressions on eosinophils . Positive_regulation ITGB2 MAPK15 20421794 2256526 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Positive_regulation ITGB2 MAPK15 23935932 2826748 Adiponectin inhibits neutrophil phagocytosis of Escherichia coli by inhibition of PKB and ERK 1/2 signalling and [Mac-1] *activation* . Positive_regulation ITGB2 MAPK3 11121138 758450 Inhibition of the activity *caused* growth inhibition of the [Mac-1] , Mac-2 A , and JK cell lines . Positive_regulation ITGB2 MAPK3 11529937 853716 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Positive_regulation ITGB2 MAPK3 12600815 1099037 IL-3 , IL-5 , and GM-CSF could enhance p38 and NF-kappaB activity and *induce* ICAM-1 , CD11b , and [CD18] expressions on eosinophils . Positive_regulation ITGB2 MAPK3 20421794 2256533 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Positive_regulation ITGB2 MAPK3 23935932 2826756 Adiponectin inhibits neutrophil phagocytosis of Escherichia coli by inhibition of PKB and ERK 1/2 signalling and [Mac-1] *activation* . Positive_regulation ITGB2 MAPK4 11121138 758451 Inhibition of the activity *caused* growth inhibition of the [Mac-1] , Mac-2 A , and JK cell lines . Positive_regulation ITGB2 MAPK4 11529937 853717 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Positive_regulation ITGB2 MAPK4 12600815 1099038 IL-3 , IL-5 , and GM-CSF could enhance p38 and NF-kappaB activity and *induce* ICAM-1 , CD11b , and [CD18] expressions on eosinophils . Positive_regulation ITGB2 MAPK4 20421794 2256534 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Positive_regulation ITGB2 MAPK4 23935932 2826757 Adiponectin inhibits neutrophil phagocytosis of Escherichia coli by inhibition of PKB and ERK 1/2 signalling and [Mac-1] *activation* . Positive_regulation ITGB2 MAPK6 11121138 758452 Inhibition of the activity *caused* growth inhibition of the [Mac-1] , Mac-2 A , and JK cell lines . Positive_regulation ITGB2 MAPK6 11529937 853718 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Positive_regulation ITGB2 MAPK6 12600815 1099039 IL-3 , IL-5 , and GM-CSF could enhance p38 and NF-kappaB activity and *induce* ICAM-1 , CD11b , and [CD18] expressions on eosinophils . Positive_regulation ITGB2 MAPK6 20421794 2256535 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Positive_regulation ITGB2 MAPK6 23935932 2826758 Adiponectin inhibits neutrophil phagocytosis of Escherichia coli by inhibition of PKB and ERK 1/2 signalling and [Mac-1] *activation* . Positive_regulation ITGB2 MAPK7 11121138 758453 Inhibition of the activity *caused* growth inhibition of the [Mac-1] , Mac-2 A , and JK cell lines . Positive_regulation ITGB2 MAPK7 11529937 853719 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Positive_regulation ITGB2 MAPK7 12600815 1099040 IL-3 , IL-5 , and GM-CSF could enhance p38 and NF-kappaB activity and *induce* ICAM-1 , CD11b , and [CD18] expressions on eosinophils . Positive_regulation ITGB2 MAPK7 20421794 2256536 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Positive_regulation ITGB2 MAPK7 23935932 2826759 Adiponectin inhibits neutrophil phagocytosis of Escherichia coli by inhibition of PKB and ERK 1/2 signalling and [Mac-1] *activation* . Positive_regulation ITGB2 MAPK8 11121138 758454 Inhibition of the activity *caused* growth inhibition of the [Mac-1] , Mac-2 A , and JK cell lines . Positive_regulation ITGB2 MAPK8 11529937 853720 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Positive_regulation ITGB2 MAPK8 12600815 1099041 IL-3 , IL-5 , and GM-CSF could enhance p38 and NF-kappaB activity and *induce* ICAM-1 , CD11b , and [CD18] expressions on eosinophils . Positive_regulation ITGB2 MAPK8 20421794 2256537 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Positive_regulation ITGB2 MAPK8 23935932 2826760 Adiponectin inhibits neutrophil phagocytosis of Escherichia coli by inhibition of PKB and ERK 1/2 signalling and [Mac-1] *activation* . Positive_regulation ITGB2 MAPK9 11121138 758455 Inhibition of the activity *caused* growth inhibition of the [Mac-1] , Mac-2 A , and JK cell lines . Positive_regulation ITGB2 MAPK9 11529937 853721 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Positive_regulation ITGB2 MAPK9 12600815 1099042 IL-3 , IL-5 , and GM-CSF could enhance p38 and NF-kappaB activity and *induce* ICAM-1 , CD11b , and [CD18] expressions on eosinophils . Positive_regulation ITGB2 MAPK9 20421794 2256538 This decrease in p38 activation *results* in decreased neutrophil [CD11b/CD18] molecule expression . Positive_regulation ITGB2 MAPK9 23935932 2826761 Adiponectin inhibits neutrophil phagocytosis of Escherichia coli by inhibition of PKB and ERK 1/2 signalling and [Mac-1] *activation* . Positive_regulation ITGB2 MARCKSL1 10497314 647529 We observed that the expression of the exogenous wild type greatly *enhanced* [LFA-1] mediated cell-cell adhesion in U937 cells treated with phorbol 12-myristate 13-acetate ( PMA ) . Positive_regulation ITGB2 MARCKSL1 10497314 647530 However , phosphorylated alone could not *induce* [LFA-1] mediated cell-cell adhesion unless phorbol esters were added , suggesting that the phosphorylation of other proteins might also be involved . Positive_regulation ITGB2 MCOLN1 1346139 179092 Furthermore , binding of mAb 24 to T cell [LFA-1] in the *presence* of either Mn2+ or was found to be specifically inhibited by Ca2+ , suggestive of a negative regulatory role for Ca2+ in the control of leukocyte integrin function . Positive_regulation ITGB2 MCOLN1 1346139 179093 Analysis of T cell binding to ICAM-1 via [LFA-1] in the *presence* of or Mn2+ , confirmed that Ca2+ exerted inhibitory effects upon LFA-1 function . Positive_regulation ITGB2 MCOLN1 9765268 537960 In this study we show that soluble LFA-1 I domain blocks ICAM-1 binding of the high affinity *induced* form of [LFA-1] but not the phorbol ester induced form . Positive_regulation ITGB2 MCOLN1 9765268 537962 In addition , the binding of *activated* [LFA-1] to ICAM-1 is blocked by peptides covering the alpha4-beta3 loop , the beta3-alpha5 loop , and the alpha5 helix of the I domain , whereas none of the peptides tested blocks phorbol ester mediated adhesion . Positive_regulation ITGB2 MDM1 16705672 1589867 HIV-1 infected induced significant *increases* in [Mac-1] , glial fibrillary acidic protein , ionized calcium binding adapter molecule 1 , and proinflammatory cytokine RNA and/or protein expression when compared with HSV/HIV-1- and HIV-1 infected HFA and sham operated mice . Positive_regulation ITGB2 MDM2 16705672 1589868 HIV-1 infected *induced* significant increases in [Mac-1] , glial fibrillary acidic protein , ionized calcium binding adapter molecule 1 , and proinflammatory cytokine RNA and/or protein expression when compared with HSV/HIV-1- and HIV-1 infected HFA and sham operated mice . Positive_regulation ITGB2 MDM4 16705672 1589869 HIV-1 infected induced significant *increases* in [Mac-1] , glial fibrillary acidic protein , ionized calcium binding adapter molecule 1 , and proinflammatory cytokine RNA and/or protein expression when compared with HSV/HIV-1- and HIV-1 infected HFA and sham operated mice . Positive_regulation ITGB2 MED1 9152024 431023 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED10 9152024 431019 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED11 9152024 431022 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED12 9152024 430994 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED13 9152024 431004 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED13L 9152024 431005 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED14 9152024 431009 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED15 9152024 430995 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED16 9152024 430998 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED17 9152024 431011 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED18 9152024 431018 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED19 9152024 431021 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED20 9152024 430997 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED21 9152024 430992 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED22 9152024 430993 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED23 9152024 431010 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED24 9152024 431006 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED25 9152024 431020 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED26 9152024 431012 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED27 9152024 431013 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED28 9152024 431016 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED29 9152024 431008 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED30 9152024 431007 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED31 9152024 431015 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED4 9152024 431000 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED6 9152024 431002 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED7 9152024 431014 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED8 9152024 431003 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MED9 9152024 431017 *Activation* of the beta2 [integrin Mac-1] ( CD11b/CD18 ) by an endogenous lipid of human neutrophils and HL-60 cells . Positive_regulation ITGB2 MET 11069808 747874 rTFPI also significantly inhibited several *induced* neutrophil functions , as well as increases in the expression of CD11b and [CD18] on the neutrophil cell surface in vitro . Positive_regulation ITGB2 MET 3924634 49111 Stimulation of normal granulocytes with , C5a-desArg , or calcium ionophore resulted in increased expression of Mo1 and Leu M5 antigens on the cell surface , but did not significantly *increase* expression of [LFA-1] antigen . Positive_regulation ITGB2 MME 9682953 521394 The results from the biocompatibility tests demonstrated that the cleaner treated prosthesis *induced* significantly lower [CD18] expression than the scoured control fabric , and was also associated with a milder inflammatory response and a more rapid rate of healing during the 30 day animal trial . Positive_regulation ITGB2 MMP9 9754865 535241 Ligation of selectin L and integrin [CD11b/CD18] ( Mac-1 ) *induces* release of ( MMP-9 ) from human neutrophils . Positive_regulation ITGB2 MRE11A 12171996 974285 The small GTPase is *required* for Mn ( 2+ ) - and antibody induced [LFA-1-] and VLA-4 mediated cell adhesion . Positive_regulation ITGB2 MRE11A 20864093 2337148 In T lymphocytes , *mediates* [LFA-1] activation and LFA-1 mediated adhesion . Positive_regulation ITGB2 MYO10 11254681 794083 Stromal cell derived factor-1 induced [LFA-1] activation during in vivo migration of T cell hybridoma cells *requires* Gq/11 , RhoA , and , as well as Gi and Cdc42 . Positive_regulation ITGB2 MYO16 11254681 794081 Stromal cell derived factor-1 induced [LFA-1] activation during in vivo migration of T cell hybridoma cells *requires* Gq/11 , RhoA , and , as well as Gi and Cdc42 . Positive_regulation ITGB2 MYO19 11254681 794080 Stromal cell derived factor-1 induced [LFA-1] activation during in vivo migration of T cell hybridoma cells *requires* Gq/11 , RhoA , and , as well as Gi and Cdc42 . Positive_regulation ITGB2 MYO6 11254681 794084 Stromal cell derived factor-1 induced [LFA-1] activation during in vivo migration of T cell hybridoma cells *requires* Gq/11 , RhoA , and , as well as Gi and Cdc42 . Positive_regulation ITGB2 NFKB1 12600815 1099043 IL-3 , IL-5 , and GM-CSF could enhance p38 MAPK and activity and *induce* ICAM-1 , CD11b , and [CD18] expressions on eosinophils . Positive_regulation ITGB2 NFKB1 16403785 1527140 Through its interaction with [Mac-1] , Lp(a) *induced* activation of the proinflammatory transcription factor , as well as the NFkappaB related expression of prothrombotic tissue factor . Positive_regulation ITGB2 NFKB1 9024987 405811 The inhibitor , tepoxalin , *suppresses* surface expression of the cell adhesion molecules CD62E , [CD11b/CD18] and CD106 . Positive_regulation ITGB2 NOS1 9218092 442074 Indomethacin induced [Mac-1] upregulation was *prevented* by a inhibitor . Positive_regulation ITGB2 NOS2 9218092 442075 Indomethacin induced [Mac-1] upregulation was *prevented* by a inhibitor . Positive_regulation ITGB2 NOS3 9218092 442076 Indomethacin induced [Mac-1] upregulation was *prevented* by a inhibitor . Positive_regulation ITGB2 NPY4R 9723775 529266 Inhibitors of protein , protein kinase C ( PKC ) , protein tyrosine kinase (PTK) , calmodulin and calmodulin dependent kinase-II (CamK II) *prevented* [LFA-1] expression on cisplatin treated macrophages . Positive_regulation ITGB2 PABPC1 12485937 1032969 We hypothesize that a -- an enhanceosome -- that includes GABP , other transcription factors , and coactivators , dynamically *regulates* [CD18] expression in myeloid cells . Positive_regulation ITGB2 PAF1 1362329 208092 Neither dose of phalloidin altered the upregulation of neutrophil membrane [CD11/CD18] glycoprotein adherence complex *induced* by or LTB4 . Positive_regulation ITGB2 PAF1 7531948 291986 Butanol and PTX also significantly reduced the *upregulation* of [CD11b/CD18] by f-methionyl-leucyl-phenylalanine ( fMLP ) and but not by phorbol myristate acetate ( PMA ) . Positive_regulation ITGB2 PAF1 7686761 222298 ( 10 ( -7 ) M ) *caused* a 42.8 +/- 5.7 % ( mean +/- SEM ) increase in [Mac-1] expression in eosinophils ( P < 0.01 ) and a 34.6 +/- 9.2 % increase in Mac-1 expression in neutrophils ( P < 0.05 ) . Positive_regulation ITGB2 PAF1 8047994 267086 also *enhanced* [CD18] expression ( 6.1 +/- 1.1 mean fluorescence intensity versus 10.3 +/- 2.3 ) , but beta-adrenoreceptor stimulation ( 10.1 +/- 2.1 ) and AC activation ( 9.7 +/- 1.9 ) had no discernible effect . Positive_regulation ITGB2 PAF1 9227560 443318 Pretreatment of neutrophils with SNAP or 8-bromoguanosine 3',5'-cyclic monophosphate did not reduce *induced* [CD11b/CD18] expression determined by flow cytometry , nor did simultaneous treatment of myocytes with IL-1 beta and SNAP decrease IL-1 beta induced intercellular adhesion molecule-1 expression determined by immunofluorescence staining and enzyme linked immunosorbent assay . Positive_regulation ITGB2 PAF1 9335316 458001 *up-regulated* the expression of [CDllb/CD18] , down-regulated L-selectin , and also increased F-actin assembly in eosinophils . Positive_regulation ITGB2 PAF1 9523024 493892 Coincubation of neutrophils with alpha-Toc and pretreatment of HUVEC with alpha-Toc significantly reduced *induced* [CD11b/CD18] expression and IL-1 beta induced upregulation of ICAM-1 and VCAM-1 , respectively . Positive_regulation ITGB2 PAIP1 12485937 1032966 We hypothesize that a -- an enhanceosome -- that includes GABP , other transcription factors , and coactivators , dynamically *regulates* [CD18] expression in myeloid cells . Positive_regulation ITGB2 PAM 22496642 2583706 Moreover , coactivation of the Mincle and TLR2 pathways by TDM and treatment synergistically *induced* [CD11b/CD18] surface expression , reactive oxygen species , and TNFa production by neutrophils . Positive_regulation ITGB2 PARP1 12171996 974283 The small GTPase is *required* for Mn ( 2+ ) - and antibody induced [LFA-1-] and VLA-4 mediated cell adhesion . Positive_regulation ITGB2 PARP1 20864093 2337146 In T lymphocytes , *mediates* [LFA-1] activation and LFA-1 mediated adhesion . Positive_regulation ITGB2 PDLIM7 2157887 131497 expression in all cell lines *induced* growth in large clumps and expression of the cellular adhesion molecules ICAM-1 , [LFA-1] , and LFA-3 in those cell lines which constitutively express low levels . Positive_regulation ITGB2 PDLIM7 8093369 210047 also *induced* increased CD21 , ICAM-1 and [LFA-1] surface expression on transfected primary T-cells , and CD21 and ICAM-1 in four of five B-cell chronic lymphocytic leukemias tested . Positive_regulation ITGB2 PGP 23041749 2716457 most likely *activated* [Mac-1] by initiating a conformational change , since the expression pattern of Mac-1 on the cell surface did not change significantly . Positive_regulation ITGB2 PHKA2 20805505 2318284 Furthermore , is *essential* for LFA-1 mediated CD8 T-cell adhesion and [LFA-1] costimulation of CD8 T-cell migration . Positive_regulation ITGB2 PI3 11165259 782765 Specific inhibitors *suppressed* both [LFA-1] activation and Rap1GTP generation , and abrogation of Rap1GTP by retroviral over-expression of a specific Rap1 GTPase activating protein , SPA-1 , totally inhibited the LFA-1/ICAM-1 mediated cell adhesion . Positive_regulation ITGB2 PIK3CA 14960575 1227758 We have identified Vav , a guanine nucleotide exchange factor for Rac-1 , and PI3K/Akt , as regulators of the activation and inactivation phases of the activity of Rac-1 , respectively , in the context of LFA-1 signaling based on the following experimental evidence : ( i ) [LFA-1] induced *activation* of Vav and with kinetics consistent with a regulatory role for these molecules on Rac-1 , ( ii ) overexpression of a constitutively active Vav mutant induces activation of Rac independently of LFA-1 stimulation whereas overexpression of a dominant negative Vav mutant blocks LFA-1 mediated Rac activation , ( iii ) pharmacological inhibition of PI3K/Akt prevented the fall in the activity of Rac-1 after its initial activation but had no effect on Vav activity , and ( iv ) overexpression of a dominant negative or a constitutively active Akt-1 induced or inhibited , respectively , Rac-1 activity . Positive_regulation ITGB2 PIK3CA 17336925 1712216 Inhibitors of *inhibited* activation of [LFA-1] by ionomycin , but not by PMA , whereas the protein kinase C inhibitor inhibited the effects of PMA , but not ionomycin . Positive_regulation ITGB2 PIK3R1 14960575 1227759 We have identified Vav , a guanine nucleotide exchange factor for Rac-1 , and PI3K/Akt , as regulators of the activation and inactivation phases of the activity of Rac-1 , respectively , in the context of LFA-1 signaling based on the following experimental evidence : ( i ) [LFA-1] induced *activation* of Vav and with kinetics consistent with a regulatory role for these molecules on Rac-1 , ( ii ) overexpression of a constitutively active Vav mutant induces activation of Rac independently of LFA-1 stimulation whereas overexpression of a dominant negative Vav mutant blocks LFA-1 mediated Rac activation , ( iii ) pharmacological inhibition of PI3K/Akt prevented the fall in the activity of Rac-1 after its initial activation but had no effect on Vav activity , and ( iv ) overexpression of a dominant negative or a constitutively active Akt-1 induced or inhibited , respectively , Rac-1 activity . Positive_regulation ITGB2 PIK3R1 17336925 1712217 Inhibitors of *inhibited* activation of [LFA-1] by ionomycin , but not by PMA , whereas the protein kinase C inhibitor inhibited the effects of PMA , but not ionomycin . Positive_regulation ITGB2 PLA2G1B 8773578 379612 at a concentration of 10 microg/mL *increased* the [Mac-1] expression by 150 % compared with unstimulated cells at 30 min and after . Positive_regulation ITGB2 PLA2G1B 8773578 379615 The [Mac-1] induction *mediated* by was inhibited by an anti-PLA2-II antibody , which was able to inhibit the catalytic activity . Positive_regulation ITGB2 PLA2G1B 8773578 379617 However , the [Mac-1] *induction* by was not inhibited by a 5-lipoxygenase , cyclooxygenase inhibitor , or a platelet activating factor antagonist . Positive_regulation ITGB2 PLA2G1B 9529158 496511 However , this [Mac-1] upregulation was significantly *inhibited* by two disparate inhibitors . Positive_regulation ITGB2 PLA2G1B 9590257 504796 Type II ( PLA2-II ) also *induces* translocation of [Mac-1] from secretory vesicles . Positive_regulation ITGB2 PLA2G4A 10477614 643237 However , inhibition neither prevented CBRM1/5 expression nor *blocked* surface [Mac-1] up-regulation caused by IL-5 . Positive_regulation ITGB2 PLAT 16601674 1556487 In vitro analysis shows that *promotes* [Mac-1] mediated adhesion , whereas PAI-1 and LRP facilitate its transition to cell retraction . Positive_regulation ITGB2 PLAUR 18941116 2034663 Thus , either uPA/uPAR interaction , [Mac-1] *activation* , or prevention of its association with triggers a signaling pathway leading to the inefficient release of HIV from monocytic cells . Positive_regulation ITGB2 PLD1 19934331 2172256 Specifically , RhoA and were crucially *involved* in [LFA-1] affinity triggering by CXCL12 in all analyzed patients . Positive_regulation ITGB2 PLD1 8872506 389676 [Anti-CD18-antibodies] bound to protein A-positive Staphylococcus aureus bacteria *induced* a significant activation . Positive_regulation ITGB2 PLD2 8872506 389677 [Anti-CD18-antibodies] bound to protein A-positive Staphylococcus aureus bacteria *induced* a significant activation . Positive_regulation ITGB2 PLD3 8872506 389672 [Anti-CD18-antibodies] bound to protein A-positive Staphylococcus aureus bacteria *induced* a significant activation . Positive_regulation ITGB2 PLD4 8872506 389673 [Anti-CD18-antibodies] bound to protein A-positive Staphylococcus aureus bacteria *induced* a significant activation . Positive_regulation ITGB2 PLD5 8872506 389674 [Anti-CD18-antibodies] bound to protein A-positive Staphylococcus aureus bacteria *induced* a significant activation . Positive_regulation ITGB2 PLD6 8872506 389675 [Anti-CD18-antibodies] bound to protein A-positive Staphylococcus aureus bacteria *induced* a significant activation . Positive_regulation ITGB2 POT1 20957749 2343700 Active , via its binding to RapL ( regulator for cell adhesion and polarization enriched in lymphoid tissues ) , *mediates* [LFA-1] integrin activation . Positive_regulation ITGB2 PRKACB 10380896 623964 A PKC inhibitor , but not a inhibitor , *suppressed* [CD11b/CD18] up-regulation , and alpha-Toc slightly decreased fMLP- and oxLDL induced activation of PKC . Positive_regulation ITGB2 PRKACG 10380896 623965 A PKC inhibitor , but not a inhibitor , *suppressed* [CD11b/CD18] up-regulation , and alpha-Toc slightly decreased fMLP- and oxLDL induced activation of PKC . Positive_regulation ITGB2 PRKAR1A 10380896 623966 A PKC inhibitor , but not a inhibitor , *suppressed* [CD11b/CD18] up-regulation , and alpha-Toc slightly decreased fMLP- and oxLDL induced activation of PKC . Positive_regulation ITGB2 PRKAR1B 10380896 623967 A PKC inhibitor , but not a inhibitor , *suppressed* [CD11b/CD18] up-regulation , and alpha-Toc slightly decreased fMLP- and oxLDL induced activation of PKC . Positive_regulation ITGB2 PRKAR2A 10380896 623968 A PKC inhibitor , but not a inhibitor , *suppressed* [CD11b/CD18] up-regulation , and alpha-Toc slightly decreased fMLP- and oxLDL induced activation of PKC . Positive_regulation ITGB2 PRKAR2B 10380896 623969 A PKC inhibitor , but not a inhibitor , *suppressed* [CD11b/CD18] up-regulation , and alpha-Toc slightly decreased fMLP- and oxLDL induced activation of PKC . Positive_regulation ITGB2 PRKCB 12202398 983062 Moreover , HLA-DR mediated cell death of activated monocytes implicates a regulatory loop between the [HLA-DR/CD18] complex and the downstream *activation* of . Positive_regulation ITGB2 PRKCZ 19086264 2003589 The objective of this study was to examine the *role* of in interleukin (IL)-8 mediated activation of [Mac-1] ( CD11b/CD18 ) in human neutrophils . Positive_regulation ITGB2 PSMD4 9066653 418451 When cells were cultured separately with FCS or ASF , and the adhesion molecules were analysed using flow cytometry , the expression of [LFA-1] molecules on AH66F cells was not changed by eitherv FCS or ASF , but the ICAM-1 molecule on M-cells was *increased* time-dependently by . Positive_regulation ITGB2 PTK2B 10359604 619408 Furthermore , the interaction of the activated integrin [LFA-1] with its ligand intercellular adhesion molecule 1 *induced* the activation of the cytoplasmic tyrosine kinases focal adhesion kinase ( FAK ) and . Positive_regulation ITGB2 PTPRC 8405045 232400 *mediated* regulation of [LFA1] function in human natural killer cells . Positive_regulation ITGB2 PXN 20388733 2245289 Phosphorylation of at threonine 538 by PKCdelta *regulates* [LFA1] mediated adhesion of lymphoid cells . Positive_regulation ITGB2 RAD50 12171996 974286 The small GTPase is *required* for Mn ( 2+ ) - and antibody induced [LFA-1-] and VLA-4 mediated cell adhesion . Positive_regulation ITGB2 RAD50 20864093 2337149 In T lymphocytes , *mediates* [LFA-1] activation and LFA-1 mediated adhesion . Positive_regulation ITGB2 RAD50 20957749 2343703 Active , via its binding to RapL ( regulator for cell adhesion and polarization enriched in lymphoid tissues ) , *mediates* [LFA-1] integrin activation . Positive_regulation ITGB2 RAP1A 11165259 782769 These results suggest that CD98 cross linking activates [LFA-1] via the PI3K signaling pathway and *induces* accumulation of in a LFA-1 dependent manner , which in turn mediates the cytoskeleton dependent cell adhesion process . Positive_regulation ITGB2 RELA 12600815 1099044 IL-3 , IL-5 , and GM-CSF could enhance p38 MAPK and activity and *induce* ICAM-1 , CD11b , and [CD18] expressions on eosinophils . Positive_regulation ITGB2 RELA 16403785 1527141 Through its interaction with [Mac-1] , Lp(a) *induced* activation of the proinflammatory transcription factor , as well as the NFkappaB related expression of prothrombotic tissue factor . Positive_regulation ITGB2 RELA 9024987 405812 The inhibitor , tepoxalin , *suppresses* surface expression of the cell adhesion molecules CD62E , [CD11b/CD18] and CD106 . Positive_regulation ITGB2 RHO 22433673 2618076 Moreover , inhibition *attenuated* M1 protein induced [Mac-1] expression on neutrophils . Positive_regulation ITGB2 RHOA 11254681 794082 Stromal cell derived factor-1 induced [LFA-1] activation during in vivo migration of T cell hybridoma cells *requires* Gq/11 , , and myosin , as well as Gi and Cdc42 . Positive_regulation ITGB2 RHOA 11254681 794091 G ( q/11 ) , , and contraction are specifically *required* for [LFA-1] activation , since 1 ) they are essential for LFA-1 dependent migration toward low SDF-1 concentrations through ICAM-1 coated filters , but not for migration toward high SDF-1 levels , which is LFA-1 independent ; Positive_regulation ITGB2 RHOA 11254681 794094 We show here that zeta associated protein 70-induced [LFA-1] activation *requires* neither Cdc42 and nor contraction and is thus quite different from that induced by SDF-1 . Positive_regulation ITGB2 RHOA 19934331 2172255 Specifically , and phospholipase D1 were crucially *involved* in [LFA-1] affinity triggering by CXCL12 in all analyzed patients . Positive_regulation ITGB2 RRAS 11257001 794324 Finally , in a macrophage cell line , *activates* the [alpha(M)beta(2) integrin] via the small GTPase Rap1 , leading to phagocytosis of opsonized red blood cells , whereas Ras does not . Positive_regulation ITGB2 RUNX3 16164020 1456211 The functional relevance of these elements are illustrated by the fact that overexpression *leads* to enhanced [CD11a/CD18] levels , whereas RUNX1-ETO expressing cells exhibit a weak/absent CD11a/CD18 integrin cell surface expression . Positive_regulation ITGB2 S100A8 12626582 1066812 In this study , we report that S100A8 , S100A9 , and S100A8/A9 caused neutrophil chemotaxis at concentrations of 10 ( -12 ) -10 ( -9 ) M . S100A8 , S100A9 , and stimulated shedding of L-selectin , up-regulated and *activated* [Mac-1] , and induced neutrophil adhesion to fibrinogen in vitro . Positive_regulation ITGB2 S100A9 9570563 501600 The human S100 protein is a novel *activator* of the beta 2 [integrin Mac-1] on neutrophils . Positive_regulation ITGB2 SELE 9218615 442296 We examined whether interaction of PMNs with also *leads* to activation of [CD11b/CD18] ( Mac-1 , alphaMbeta2 ) , an event that can promote firm adhesion . Positive_regulation ITGB2 SELL 11283159 799321 Inhibition of L-selectin shedding potentiated activation of [LFA-1] and Mac-1 *induced* by cross linking as shown by activation epitope expression and binding of ICAM-1 conjugated beads . Positive_regulation ITGB2 SELL 12147632 970081 [LFA-1] may enhance co-stimulation , and both LFA-1 and are *involved* in T cell trafficking . Positive_regulation ITGB2 SELL 1714481 163515 Endothelial *mediated* [CD18] activation . Positive_regulation ITGB2 SELL 24127491 2858989 The complex signals through Src family kinases , ITAM domain containing adaptor proteins , and other kinases to ultimately *result* in [LFA-1] activation . Positive_regulation ITGB2 SELL 7532664 292148 In addition , cross linking of *induced* an up-regulation of surface [Mac-1] expression on neutrophils . Positive_regulation ITGB2 SELL 7543524 314319 Surface expression of [CD18] and an activation dependent epitope , as detected with mAb24 , also increased in *response* to cross linking . Positive_regulation ITGB2 SELP 7543539 314327 did not *stimulate* increased surface expression of integrin [CD11b/CD18] and did not enhance binding of iC3b coated erythrocytes , a CD11b/CD18 mediated functional response . Positive_regulation ITGB2 SELPLG 15661900 1365114 PSGL-1 cross linking induced activation of protein kinase C isoforms , and the increased Th1 cell adhesion observed under flow and also static conditions was strongly inhibited by calphostin C , implicating protein kinase C in the intracellular signaling in mediated [LFA-1] *activation* . Positive_regulation ITGB2 SELPLG 17332469 1747965 T cell associated [CD18] but not CD62L , ICAM-1 , or is *required* for the induction of chronic colitis . Positive_regulation ITGB2 SELPLG 24127491 2858990 The complex signals through Src family kinases , ITAM domain containing adaptor proteins , and other kinases to ultimately *result* in [LFA-1] activation . Positive_regulation ITGB2 SLC3A2 11165259 782750 *induces* [LFA-1] mediated cell adhesion in lymphoid cells via activation of Rap1 . Positive_regulation ITGB2 SLC3A2 11165259 782754 We show that cross linking persistently activates Rap1 GTPase in a LFA-1 dependent manner and *induces* [LFA-1/ICAM-1] mediated cell adhesion in lymphocytes . Positive_regulation ITGB2 SLC3A2 11165259 782768 These results suggest that cross linking *activates* [LFA-1] via the PI3K signaling pathway and induces accumulation of Rap1GTP in a LFA-1 dependent manner , which in turn mediates the cytoskeleton dependent cell adhesion process . Positive_regulation ITGB2 SOCS1 14528303 1158390 Here , intracellular phosphoprotein staining with 13-dimensional flow cytometry showed that [LFA-1] activation *induced* phosphorylation of the beta ( 2 ) integrin chain and release of , and mediated signaling of kinase Erk1/2 through cytohesin-1 . Positive_regulation ITGB2 SP1 9582348 504035 Transfection of into Drosophila Schneider cells , which otherwise lack Sp1 , *activates* the [CD18] promoter dramatically . Positive_regulation ITGB2 SPP1 19454691 2084552 *enhances* phagocytosis through a novel osteopontin receptor , the [alphaXbeta2 integrin] . Positive_regulation ITGB2 STAT3 10858439 722213 Activation of *leads* to homotypic cell aggregation , increased expression of intercellular adhesion molecule 1 ( ICAM-1 ) , [CD18] , and CD11b , and activation of signaling through CD18 containing integrins . Positive_regulation ITGB2 SYK 10222060 609559 Furthermore , [LFA-1beta] costimulation with CD3 *induces* tyrosine phosphorylation of associated with FAK . Positive_regulation ITGB2 SYK 18550846 1952289 However , DeltaCD neutrophils rolling on P-selectin did not trigger *dependent* activation of [LFA-1] to slow rolling on ICAM-1 . Positive_regulation ITGB2 SYNCRIP 12485937 1032965 We hypothesize that a -- an enhanceosome -- that includes GABP , other transcription factors , and coactivators , dynamically *regulates* [CD18] expression in myeloid cells . Positive_regulation ITGB2 TCF12 15886116 1406836 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , activation of the NF-kappaB , inside-out *activation* of the integrin [LFA-1] , TCR clustering , and polarisation of the T cell . Positive_regulation ITGB2 TCF15 15886116 1406837 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , *activation* of the NF-kappaB , inside-out activation of the integrin [LFA-1] , TCR clustering , and polarisation of the T cell . Positive_regulation ITGB2 TCF19 15886116 1406838 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , *activation* of the NF-kappaB , inside-out activation of the integrin [LFA-1] , TCR clustering , and polarisation of the T cell . Positive_regulation ITGB2 TCF20 15886116 1406839 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , activation of the NF-kappaB , inside-out *activation* of the integrin [LFA-1] , TCR clustering , and polarisation of the T cell . Positive_regulation ITGB2 TCF21 15886116 1406840 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , *activation* of the NF-kappaB , inside-out activation of the integrin [LFA-1] , TCR clustering , and polarisation of the T cell . Positive_regulation ITGB2 TCF23 15886116 1406845 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , *activation* of the NF-kappaB , inside-out activation of the integrin [LFA-1] , TCR clustering , and polarisation of the T cell . Positive_regulation ITGB2 TCF24 15886116 1406847 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , *activation* of the NF-kappaB , inside-out activation of the integrin [LFA-1] , TCR clustering , and polarisation of the T cell . Positive_regulation ITGB2 TCF25 15886116 1406846 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , activation of the NF-kappaB , inside-out *activation* of the integrin [LFA-1] , TCR clustering , and polarisation of the T cell . Positive_regulation ITGB2 TCF3 15886116 1406841 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , activation of the NF-kappaB , inside-out *activation* of the integrin [LFA-1] , TCR clustering , and polarisation of the T cell . Positive_regulation ITGB2 TCF4 15886116 1406842 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , *activation* of the NF-kappaB , inside-out activation of the integrin [LFA-1] , TCR clustering , and polarisation of the T cell . Positive_regulation ITGB2 TCF7 15886116 1406843 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , activation of the NF-kappaB , inside-out *activation* of the integrin [LFA-1] , TCR clustering , and polarisation of the T cell . Positive_regulation ITGB2 TDGF1P3 2978519 104116 [LFA-1] mediates the binding of killer T cells to targets , CR3 mediates binding of phagocytes to iC3b coated surfaces and to endothelial cells , and LFA-1 , , and p150 ,95 each *mediate* the binding of bacterial lipopolysaccharide . Positive_regulation ITGB2 TDGF1P3 8757624 377743 Soluble CD16 bound to CR3 ( [CDllb/CD18] ) - and CR4 ( CDllc/CD18 ) - positive leukocytes and cell lines , the labeling was inhibited by anti-CD11b , CD11c or CD18 mAbs , and the up-regulation of and CR4 *led* to an increased fixation of sCD16 . Positive_regulation ITGB2 TDGF1P4 8757624 377744 Soluble CD16 bound to CR3 ( CDllb/CD18 ) - and CR4 ( [CDllc/CD18] ) - positive leukocytes and cell lines , the labeling was inhibited by anti-CD11b , CD11c or CD18 mAbs , and the up-regulation of CR3 and *led* to an increased fixation of sCD16 . Positive_regulation ITGB2 TERF1 20957749 2343697 Active , via its binding to RapL ( regulator for cell adhesion and polarization enriched in lymphoid tissues ) , *mediates* [LFA-1] integrin activation . Positive_regulation ITGB2 TERF2 12171996 974280 The small GTPase is *required* for Mn ( 2+ ) - and antibody induced [LFA-1-] and VLA-4 mediated cell adhesion . Positive_regulation ITGB2 TERF2 20864093 2337143 In T lymphocytes , *mediates* [LFA-1] activation and LFA-1 mediated adhesion . Positive_regulation ITGB2 TERF2 20957749 2343698 Active , via its binding to RapL ( regulator for cell adhesion and polarization enriched in lymphoid tissues ) , *mediates* [LFA-1] integrin activation . Positive_regulation ITGB2 TERF2IP 12171996 974282 The small GTPase is *required* for Mn ( 2+ ) - and antibody induced [LFA-1-] and VLA-4 mediated cell adhesion . Positive_regulation ITGB2 TERF2IP 20864093 2337145 In T lymphocytes , *mediates* [LFA-1] activation and LFA-1 mediated adhesion . Positive_regulation ITGB2 TERF2IP 20957749 2343701 Active , via its binding to RapL ( regulator for cell adhesion and polarization enriched in lymphoid tissues ) , *mediates* [LFA-1] integrin activation . Positive_regulation ITGB2 TGFB1 2462560 104725 The increase in alpha L synthesis and assembly into [LFA-1] complexes *induced* by occurs in parallel with elevated fibronectin receptor synthesis in THP-1 cells . Positive_regulation ITGB2 THBS1 12225809 987852 We therefore propose that may *regulate* [LFA-1/ICAM-1] mediated cell adhesion of monocytes/macrophages by either the inhibitory effect through CD47 or the promoting effect through CD36 depending on which domain/fragment is functional in a given biological setting . Positive_regulation ITGB2 TINF2 20957749 2343699 Active , via its binding to RapL ( regulator for cell adhesion and polarization enriched in lymphoid tissues ) , *mediates* [LFA-1] integrin activation . Positive_regulation ITGB2 TLR1 10863417 580424 The interaction of with FN *increased* expression of ICAM-1 and [LFA-1] on TIL cells as well . Positive_regulation ITGB2 TLR4 19622038 2137543 We found that TLR2 priming downregulates TLR4 transcription , and expression of activation *induced* major histocompatibility complex II ( MHC II ) , adhesion molecule intercellular adhesion molecule-1 ( ICAM-1 ) , phagocytosis marker [CD11b/CD18] , and Fcgamma receptor ( FcgammaR ) expression . Positive_regulation ITGB2 TNF 10843415 700077 TNF-alpha caused a significant increase in PMNL CD 11b/CD18 expression after 30 min of incubation at 37 degrees C . added simultaneously with the bacteria induced a significant *increase* in PMNL [CD11b/CD18] in both strains . Positive_regulation ITGB2 TNF 11318810 806746 Both S. pneumoniae and *caused* increases in [CD18] expression . Positive_regulation ITGB2 TNF 11318810 806747 Live S. pneumoniae stimulates polymorphonuclear leukocytes to produce an oxidative burst and *increases* expression of [CD18] , and these effects are enhanced by . Positive_regulation ITGB2 TNF 12615677 1065480 Moreover , simvastatin , atorvastatin , and cerivastatin were found to downregulate *induced* expression of CD54 and [CD18/CD11a] in isolated PBMCs obtained from normal donors as well as TNF-alpha dependent expression of these CAMs in cultured human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation ITGB2 TNF 1356917 198077 The mean fluorescence intensity ( MFI ) of monocyte CD11a was enhanced by interleukin-2 (IL-2) , TNF-alpha and TNF-beta , and that of CD11b , CD11c and [CD18] was *increased* by IL-2 , IL-4 , and TNF-beta . Positive_regulation ITGB2 TNF 17197441 1702260 Additionally , *induced* the association of [CD11b/CD18] with the NADPH oxidase subunit Nox2 ( gp91(phox) ) and phosphorylation of p47(phox) , indicating the CD11b/CD18 dependence of NADPH oxidase activation . Positive_regulation ITGB2 TNF 18164590 1855576 *induces* integrin [CD11b/CD18] ( Mac-1 ) up-regulation and migration to the CC chemokine CCL3 ( MIP-1alpha ) on human neutrophils through defined signalling pathways . Positive_regulation ITGB2 TNF 18164590 1855578 TNF-alpha induced migration was a consequence of the induced *up-regulation* of integrin [CD11b/CD18] ( Mac-1 ) on neutrophil surface . Positive_regulation ITGB2 TNF 18164590 1855579 *regulates* [Mac-1] up-regulation through signalling pathways , involving various kinases , but not JNK 1/2 . Positive_regulation ITGB2 TNF 19162037 2053979 Furthermore , JWH-133 inhibited the *induced* chemotaxis and integrin [CD18/CD11b] ( Mac-1 ) upregulation on human neutrophils . Positive_regulation ITGB2 TNF 22086659 2718860 In 38 subjects ( mean age 85 years ) , consecutively enrolled from Belfast Elderly Longitudinal Free Living Aging Study ( BELFAST ) , baseline and *stimulated* [CD11b/CD18] expression on separated monocytes and neutrophils increased with systolic blood pressure > 120 mmHg ( p = 0.05 ) and for lymphocytes , with diastolic blood pressure > 80 mmHg ( p < 0.05 ) . Positive_regulation ITGB2 TNF 7537984 301112 In contrast to the response to C5a , did not *cause* upregulation of [CD18] or shedding of L-selectin . Positive_regulation ITGB2 TNF 7768509 308391 however , only also *caused* upregulation of [Mac-1] on circulating neutrophils and liver injury . Positive_regulation ITGB2 TNF 8097206 214645 blockade *prevents* neutrophil [CD18] receptor upregulation and attenuates acute lung injury in porcine sepsis without inhibition of neutrophil oxygen radical generation . Positive_regulation ITGB2 TNF 8959153 401905 Stimulation of AM with *increased* H2O2 production and [CD11b/CD18] expression . Positive_regulation ITGB2 TNF 9197378 438550 In addition , pretreatment of infected monocytes with a TNF-alpha synthesis inhibitor , RP 55778 , or with MAbs directed against IL-1beta , confirmed the *role* of and IL-1beta in the regulation of [CD18] , CD44 , and CD54 expression . Positive_regulation ITGB2 TNF 9401798 469514 These findings suggest that in IPM and HIV-PM , enhanced ICAM-1 and [LFA-1] expression possibly *induced* by , may regulate the homing process of selected lymphocyte clones in muscle tissue . Positive_regulation ITGB2 TNF 9698257 524880 IL-1-alpha and differentially *regulate* CD4 and [Mac-1] expression in mouse microglia . Positive_regulation ITGB2 TNF 9854504 555017 *induced* [CD11b/CD18] expression on leukocytes and interferon-gamma (IFN-gamma) induced ICAM-1 expression on tumor cells may play an important role in leukocyte mediated tumor destruction . Positive_regulation ITGB2 TNFSF11 11167844 783042 These findings indicate that the persistent expression of CD11c and [CD18] is not accounted for by RANKL being presented in a soluble form and that membrane bound is not *required* for the normal integrin expression in resorbing osteoclasts . Positive_regulation ITGB2 TNMD 15664914 1365331 T-cell was *mediated* by [LFA-1-ICAM-1] interactions in accordance with an increased ICAM-1 expression on the endothelial cells after contact with H. pylori . Positive_regulation ITGB2 VAV1 14960575 1227754 We have identified Vav , a guanine nucleotide exchange factor for Rac-1 , and PI3K/Akt , as regulators of the activation and inactivation phases of the activity of Rac-1 , respectively , in the context of LFA-1 signaling based on the following experimental evidence : ( i ) [LFA-1] induced *activation* of and PI3K/Akt with kinetics consistent with a regulatory role for these molecules on Rac-1 , ( ii ) overexpression of a constitutively active Vav mutant induces activation of Rac independently of LFA-1 stimulation whereas overexpression of a dominant negative Vav mutant blocks LFA-1 mediated Rac activation , ( iii ) pharmacological inhibition of PI3K/Akt prevented the fall in the activity of Rac-1 after its initial activation but had no effect on Vav activity , and ( iv ) overexpression of a dominant negative or a constitutively active Akt-1 induced or inhibited , respectively , Rac-1 activity . Positive_regulation ITGB2 VAV1 15886116 1406844 is *required* for TCR induced calcium flux , activation of the ERK MAP kinase pathway , activation of the NF-kappaB transcription factor , inside-out activation of the integrin [LFA-1] , TCR clustering , and polarisation of the T cell . Positive_regulation ITGB2 VAV1 22177564 2518373 Both [Mac-1] activation and Dectin-1- and Mac-1 induced neutrophil effector functions *require* and Vav3 , exchange factors for RhoGTPases . Positive_regulation ITGB2 VAV3 22177564 2518374 Both [Mac-1] activation and Dectin-1- and Mac-1 induced neutrophil effector functions *require* Vav1 and , exchange factors for RhoGTPases . Positive_regulation ITGB2 VCAM1 10623819 658382 Alpha 4 beta 1 interaction *activates* [alpha L beta 2 integrin] mediated adhesion to ICAM-1 in human T cells . Positive_regulation ITGB2 VCAM1 9523024 493870 PAF *induced* upregulation of CD11b and [CD18] on neutrophils and IL-1 beta increased surface expression of ICAM-1 and on HUVEC . Positive_regulation ITGB2 WDR61 1362329 208093 Neither dose of phalloidin altered the upregulation of neutrophil membrane [CD11/CD18] glycoprotein adherence complex *induced* by or LTB4 . Positive_regulation ITGB2 WDR61 7531948 291987 Butanol and PTX also significantly reduced the *upregulation* of [CD11b/CD18] by f-methionyl-leucyl-phenylalanine ( fMLP ) and but not by phorbol myristate acetate ( PMA ) . Positive_regulation ITGB2 WDR61 7686761 222299 ( 10 ( -7 ) M ) *caused* a 42.8 +/- 5.7 % ( mean +/- SEM ) increase in [Mac-1] expression in eosinophils ( P < 0.01 ) and a 34.6 +/- 9.2 % increase in Mac-1 expression in neutrophils ( P < 0.05 ) . Positive_regulation ITGB2 WDR61 8047994 267087 also *enhanced* [CD18] expression ( 6.1 +/- 1.1 mean fluorescence intensity versus 10.3 +/- 2.3 ) , but beta-adrenoreceptor stimulation ( 10.1 +/- 2.1 ) and AC activation ( 9.7 +/- 1.9 ) had no discernible effect . Positive_regulation ITGB2 WDR61 9227560 443319 Pretreatment of neutrophils with SNAP or 8-bromoguanosine 3',5'-cyclic monophosphate did not reduce *induced* [CD11b/CD18] expression determined by flow cytometry , nor did simultaneous treatment of myocytes with IL-1 beta and SNAP decrease IL-1 beta induced intercellular adhesion molecule-1 expression determined by immunofluorescence staining and enzyme linked immunosorbent assay . Positive_regulation ITGB2 WDR61 9335316 458002 *up-regulated* the expression of [CDllb/CD18] , down-regulated L-selectin , and also increased F-actin assembly in eosinophils . Positive_regulation ITGB2 WDR61 9523024 493893 Coincubation of neutrophils with alpha-Toc and pretreatment of HUVEC with alpha-Toc significantly reduced *induced* [CD11b/CD18] expression and IL-1 beta induced upregulation of ICAM-1 and VCAM-1 , respectively . Positive_regulation ITGB2 XRCC5 12171996 974281 The small GTPase is *required* for Mn ( 2+ ) - and antibody induced [LFA-1-] and VLA-4 mediated cell adhesion . Positive_regulation ITGB2 XRCC5 20864093 2337144 In T lymphocytes , *mediates* [LFA-1] activation and LFA-1 mediated adhesion . Positive_regulation ITGB2 XRCC6 12171996 974284 The small GTPase is *required* for Mn ( 2+ ) - and antibody induced [LFA-1-] and VLA-4 mediated cell adhesion . Positive_regulation ITGB2 XRCC6 20864093 2337147 In T lymphocytes , *mediates* [LFA-1] activation and LFA-1 mediated adhesion . Positive_regulation ITGB3 CCND1 9314544 455533 Hox D3 antisense *blocked* the ability of bFGF to induce uPA and [integrin alphavbeta3] expression , yet had no effect on EC cell proliferation or bFGF mediated expression . Positive_regulation ITGB3 MMP28 16230401 1470129 Here , we have investigated the dependency of in vitro angiogenesis on *mediated* extracellular proteolysis and [integrin alpha(v)beta3] mediated cell adhesion in a three-dimensional collagen I model . Positive_regulation ITGB3 MMP7 16230401 1470144 Here , we have investigated the dependency of in vitro angiogenesis on *mediated* extracellular proteolysis and [integrin alpha(v)beta3] mediated cell adhesion in a three-dimensional collagen I model . Positive_regulation ITGB3 PECAM1 10438720 634993 CD31 stimulation of HUVECs increased the adhesive function of alphavbeta3 integrin to its ligand RGD peptide , the binding of which reached a maximum at 10 minutes after the stimulation , and the *induced* [alphavbeta3 integrin] activation on HUVECs was inhibited by inhibitors of protein kinase C and phosphatidylinositol 3 kinase ( PI3-kinase ) . Positive_regulation ITGB3 PECAM1 10438720 634999 These results indicate that mediated inside-out signaling *activates* [alphavbeta3 integrin] on endothelial cells , that the heterophilic alphavbeta3 integrin/CD31 interaction induces beta1 integrin mediated adhesion of eosinophils to endothelial cells , and that the heterophilic interaction itself is not significantly involved in firm adhesion of eosinophils to endothelial cells . Positive_regulation ITGB6 EPHB2 19581046 2194856 Taken together , the data suggest that VEGF is critical to the invasive process in human gastric cancer and that this occurs via up-regulation of [integrin alphavbeta6] expression and *activation* of . Positive_regulation ITGB6 TNF 15273742 1296416 *regulates* epithelial expression of MMP-9 and [integrin alphavbeta6] during tumour promotion . Positive_regulation ITIH4 FAS 9263011 449157 By contrast , CD4 association with was *induced* only by [gp120] ( 451 ) and gp120MN ; Positive_regulation ITIH4 IL1B 2335821 133765 Our studies indicate that , in the absence of endotoxin , HIV-1 , HIV-2 , and HIV [gp120] do not *induce* production of , IL-6 , or TNF-alpha by peripheral blood mononuclear cells . Positive_regulation ITIH4 TNF 16873189 655755 Human immunodeficiency virus type 1 envelope glycoprotein [gp120] *induces* in astrocytes . Positive_regulation ITIH4 TNF 2335821 133764 Our studies indicate that , in the absence of endotoxin , HIV-1 , HIV-2 , and HIV [gp120] do not *induce* production of IL-1 beta , IL-6 , or by peripheral blood mononuclear cells . Positive_regulation ITIH4 TNF 7704970 297591 Hence , FL [gp120] may cause TNF release from lymphocytes by binding to CD4 , while rp120cd interacts with monocytes but not lymphocytes and *induces* production by a mechanism not involving CD4 binding . Positive_regulation ITIH4 TNF 8963198 389345 The purpose of the study was to identify sites of [gp 120] , which are responsible for CD4 binding and *induce* synthesis . Positive_regulation ITK EPHB2 10958690 726176 The PTEN-deficient cells were also hyperresponsive to T-cell receptor ( TCR ) stimulation , as measured by [Itk] kinase activity , tyrosine phosphorylation of phospholipase C-gamma1 , and *activation* of compared to those in PTEN-replete cells . Positive_regulation ITPR1 TNF 18838384 1988263 Herein , we describe a novel neuron-intrinsic pathway in which the expression of the type-1 [inositol 1,4,5-trisphosphate receptor] is *regulated* by the potent pro-inflammatory cytokine . Positive_regulation ITPR1 TNF 19666470 2144028 *mediated* regulation of the [inositol 1,4,5-trisphosphate receptor] promoter . Positive_regulation ITPR1 TNF 22819818 2676766 We found that *increased* the expression of [IP3R1] and promoted osteoclastogenesis in RANKL induced mouse BMMs . Positive_regulation ITPR1 TNF 25215078 2718836 PKCa signaling pathway involves in *induced* [IP3R1] expression in human mesangial cells . Positive_regulation ITPR1 TNF 25215078 2718838 *increased* the expression of [IP3R1] and this was mediated , at least in part , through the PC-PLC/PKCa signaling pathways in HMCs . Positive_regulation ITPR2 TNF 18838384 1988264 Herein , we describe a novel neuron-intrinsic pathway in which the expression of the type-1 [inositol 1,4,5-trisphosphate receptor] is *regulated* by the potent pro-inflammatory cytokine . Positive_regulation ITPR2 TNF 19666470 2144029 *mediated* regulation of the [inositol 1,4,5-trisphosphate receptor] promoter . Positive_regulation ITPR3 TNF 18838384 1988265 Herein , we describe a novel neuron-intrinsic pathway in which the expression of the type-1 [inositol 1,4,5-trisphosphate receptor] is *regulated* by the potent pro-inflammatory cytokine . Positive_regulation ITPR3 TNF 19666470 2144030 *mediated* regulation of the [inositol 1,4,5-trisphosphate receptor] promoter . Positive_regulation IVL MAP2K6 11454875 837846 *regulates* human [involucrin] gene expression via a p38alpha - and p38delta -dependent mechanism . Positive_regulation IVL MAP2K6 15025563 1257111 CBP and P/CAF inductions of the [involucrin] expression were not *dependent* on ( mitogen activated protein kinase/extracellular-signal regulated kinase kinase ) , p38 , protein kinase C or CaM kinase ( calcium/calmodulin dependent kinase ) signalling . Positive_regulation IVL MAP2K6 17092913 1660986 Conversely , U0126 , a inhibitor , and SAHA or SBHA , 2 histone deacetylase inhibitors , *reduced* the expression of [involucrin] during calcium induced stratification . Positive_regulation IVL TGM2 8844461 387556 Immunohistochemistry of [involucrin] and *activation* of activity provided further evidence for the increase in corneocyte envelope formation observed ultrastructurally . Positive_regulation IVL TNF 23283814 2818374 IL-13 , IL-17A , ET-1 , , and IFN-? could *increase* [involucrin] protein levels in psoriatic and normal keratinocytes . Positive_regulation IVL TP63 17498688 1821955 Inhibition of with siRNA *caused* the down-regulation of jag1 expression , but not of [involucrin] , or keratin 6 and 14 . Positive_regulation JAG1 ADAM11 20974985 2348717 *Upregulation* of OX40L and [Jagged-1] by resulted in mDC-driven Th2 responses . Positive_regulation JAG1 AIRE 17202386 1681045 Work using Aire ( -/- ) mice suggests that *induces* ectopic expression of peripheral [Ags] and promotes their presentation in the thymus . Positive_regulation JAG1 AIRE 23585674 2778520 The nuclear protein expressed by mTECs *contributes* to the promiscuous expression of [self-Ags] , whereas CCR7-ligand (CCR7L) chemokines expressed by mTECs are responsible for the attraction of positively selected thymocytes . Positive_regulation JAG1 AKT1 25009698 2948404 Taken together , these findings indicate that the apoptotic activity of ß-lapachone is probably regulated by a caspase dependent cascade through activation of both intrinsic and extrinsic signaling pathways , and that inhibition of the signaling may *contribute* to ß-lapachone mediated [AGS] cell growth inhibition and apoptosis induction . Positive_regulation JAG1 AKT2 25009698 2948405 Taken together , these findings indicate that the apoptotic activity of ß-lapachone is probably regulated by a caspase dependent cascade through activation of both intrinsic and extrinsic signaling pathways , and that inhibition of the signaling may *contribute* to ß-lapachone mediated [AGS] cell growth inhibition and apoptosis induction . Positive_regulation JAG1 AKT3 25009698 2948406 Taken together , these findings indicate that the apoptotic activity of ß-lapachone is probably regulated by a caspase dependent cascade through activation of both intrinsic and extrinsic signaling pathways , and that inhibition of the signaling may *contribute* to ß-lapachone mediated [AGS] cell growth inhibition and apoptosis induction . Positive_regulation JAG1 ANXA1 22610094 2625259 Genomic responses were also assessed with domain-specific effects emerging , so the N-terminal region is required for *induction* of [JAG1] and JAM3 , whereas it is dispensable for modulation of SGPP2 . Positive_regulation JAG1 APLN 23924696 2840620 The increased expression of [Jagged-1] and Notch3 *induced* by could be abolished by extracellular signal regulated protein kinase ( ERK ) blockade . Positive_regulation JAG1 APLN 23924696 2840622 PD98059 ( ERK inhibitor ) can inhibit the activation of [Jagged-1/Notch3] *induced* by . Positive_regulation JAG1 BACE1 23831026 2815969 Here , we reveal that directly *regulates* the level of membrane anchored full-length [Jagged1 (Jag1)] , a signaling molecule important for the control of neurogenesis and astrogenesis , via interaction with its cognate Notch receptor . Positive_regulation JAG1 BRCA1 23863842 2849480 We propose that this *mediated* induction of [JAG1] may be important the regulation of breast stem/precursor cells , as knockdown of all three proteins resulted in increased tumoursphere growth and increased activity of stem cell markers such as Aldehyde Dehydrogenase 1 (ALDH1) . Positive_regulation JAG1 BTRC 10342559 616494 However , in the *presence* of alone , [Jagged1] increased erythroid colony formation twofold . Positive_regulation JAG1 CD276 8617964 353937 Expression of the B7-1 ( CD80 ) in a variety of tumor cell lines *leads* to an enhanced CD8+ T cell response to tumor [Ags] . Positive_regulation JAG1 CD4 17947638 1814308 When naive ( + ) Th cells encounter cognate pathogen *derived* [Ags] they expand and develop the capacity to express the appropriate effector cytokines for neutralizing the pathogen . Positive_regulation JAG1 CD4 23319735 2738330 Finally , IVE-TB [Ags] *induced* strong IFN-? ( + ) /TNF-a ( + ) CD8 ( + ) and TNF-a ( + ) /IL-2 ( + ) CD154 ( + ) ( + ) T cell responses in PBMC from long-term latently M. tuberculosis infected individuals . Positive_regulation JAG1 CD40 12183567 978088 A mediated signaling in M. leprae infected DCs *up-regulated* the expression of HLA [Ags] , CD86 , and CD83 but did not enhance T-cell stimulating ability . Positive_regulation JAG1 CD40LG 11466399 839988 We suggest that these mechanisms comprise an autostimulatory loop , maintaining the cascade of autoimmunity by DC presentation of [self-Ags] derived from apoptotic cells and mediated *costimulation* . Positive_regulation JAG1 CD40LG 23319735 2738329 Finally , IVE-TB [Ags] *induced* strong IFN-? ( + ) /TNF-a ( + ) CD8 ( + ) and TNF-a ( + ) /IL-2 ( + ) ( + ) /CD4 ( + ) T cell responses in PBMC from long-term latently M. tuberculosis infected individuals . Positive_regulation JAG1 CD69 20304829 2244573 The interaction with endogenous [Ags] transiently *induces* expression on T cells , which prolongs retention in the lymphoid organs . Positive_regulation JAG1 CD69 9780185 540505 We examined lymphocyte cell cycle kinetics , migration , expression of *activation* [Ags] ( and IL-2R ) , cytokine production ( IL-2 , IL-4 , IFN-gamma ) , and apoptosis . Positive_regulation JAG1 CD80 8617964 353936 Expression of the ( CD80 ) costimulatory molecule in a variety of tumor cell lines *leads* to an enhanced CD8+ T cell response to tumor [Ags] . Positive_regulation JAG1 CD8A 23319735 2738331 Finally , IVE-TB [Ags] *induced* strong IFN-? ( + ) /TNF-a ( + ) ( + ) and TNF-a ( + ) /IL-2 ( + ) CD154 ( + ) /CD4 ( + ) T cell responses in PBMC from long-term latently M. tuberculosis infected individuals . Positive_regulation JAG1 CD8A 23636062 2784479 Activation markers , cross-presentation of exogenous [Ags] , and *activation* of ( + ) T cells are much increased in Swap-70 ( -/- ) DCs . Positive_regulation JAG1 CD8B 23319735 2738332 Finally , IVE-TB [Ags] *induced* strong IFN-? ( + ) /TNF-a ( + ) ( + ) and TNF-a ( + ) /IL-2 ( + ) CD154 ( + ) /CD4 ( + ) T cell responses in PBMC from long-term latently M. tuberculosis infected individuals . Positive_regulation JAG1 CD8B 23636062 2784480 Activation markers , cross-presentation of exogenous [Ags] , and *activation* of ( + ) T cells are much increased in Swap-70 ( -/- ) DCs . Positive_regulation JAG1 CTNNB1 17474126 1743988 *induced* up-regulation of [Jagged1] precedes induction of other Notch target genes . Positive_regulation JAG1 CTNNB1 17568183 1815755 signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , [JAG1] and DKK1 genes . Positive_regulation JAG1 CTNNB1 19325125 2056335 We demonstrate that Notch is downstream of Wnt in colorectal cancer cells through *mediated* transcriptional activation of the Notch-ligand [Jagged1] . Positive_regulation JAG1 CTNNB1 19325125 2056336 We conclude that Notch activation , accomplished by *mediated* up-regulation of [Jagged1] , is required for tumorigenesis in the intestine . Positive_regulation JAG1 CUL1 10342559 616495 However , in the *presence* of alone , [Jagged1] increased erythroid colony formation twofold . Positive_regulation JAG1 DLL1 10607588 575183 On the other hand , high levels of expressed in the N2a cells themselves *stimulated* neurite extension , increased numbers of primary neurites and induced expression of [Jagged1] and Notch1 . Positive_regulation JAG1 DLL4 19816565 2148768 Expression of KSHV encoded vFLIP *induces* [JAG1] through an NFkappaB dependent mechanism , while vGPCR upregulates through a mechanism dependent on ERK . Positive_regulation JAG1 EFNB2 16430858 1521534 In co-culture experiments using EC and either Dll4- or Jagged1 expressing cells , we found that Dll4 stimulation but not [Jagged1] markedly *induced* expression . Positive_regulation JAG1 EGFR 19398556 2095064 [JAG1] expression was *dependent* upon activation in HCC827 cells , which require EGFR for survival , whereas JAG2 expression was EGFR independent in these cells . Positive_regulation JAG1 EPHB2 19019093 2093243 Selective induction of the Notch ligand [Jagged-1] in macrophages by soluble egg antigen from Schistosoma mansoni *involves* signalling . Positive_regulation JAG1 EPHB2 19019093 2093252 Taken together , our data suggest that [Jagged-1] is an *dependent* target of TLR signalling that has a macrophage-specific function in the response to SEA . Positive_regulation JAG1 F2RL1 21270400 2392765 We have shown that ( PAR(2) ) activation in the airways *leads* to allergic sensitization to concomitantly inhaled [Ags] , thus implicating PAR(2) in the pathogenesis of asthma . Positive_regulation JAG1 F9 20417219 2267810 These results indicate that maintenance of [AGS] kindling *mediated* in GEPR-9s may involve activation of AC . Positive_regulation JAG1 FGF1 19481073 2102483 *induced* [Jag1] expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation JAG1 FGF1 19481073 2102541 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Positive_regulation JAG1 FGF10 19481073 2102484 *induced* [Jag1] expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation JAG1 FGF10 19481073 2102542 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Positive_regulation JAG1 FGF11 19481073 2102485 *induced* [Jag1] expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation JAG1 FGF11 19481073 2102543 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Positive_regulation JAG1 FGF12 19481073 2102486 *induced* [Jag1] expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation JAG1 FGF12 19481073 2102544 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Positive_regulation JAG1 FGF13 19481073 2102487 *induced* [Jag1] expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation JAG1 FGF13 19481073 2102545 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Positive_regulation JAG1 FGF14 19481073 2102488 *induced* [Jag1] expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation JAG1 FGF14 19481073 2102546 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Positive_regulation JAG1 FGF16 19481073 2102489 *induced* [Jag1] expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation JAG1 FGF16 19481073 2102547 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Positive_regulation JAG1 FGF17 19481073 2102490 *induced* [Jag1] expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation JAG1 FGF17 19481073 2102548 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Positive_regulation JAG1 FGF18 19481073 2102491 *induced* [Jag1] expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation JAG1 FGF18 19481073 2102549 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Positive_regulation JAG1 FGF19 19481073 2102492 *induced* [Jag1] expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation JAG1 FGF19 19481073 2102550 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Positive_regulation JAG1 FGF2 19481073 2102493 *induced* [Jag1] expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation JAG1 FGF2 19481073 2102551 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Positive_regulation JAG1 FGF20 19481073 2102494 *induced* [Jag1] expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation JAG1 FGF20 19481073 2102552 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Positive_regulation JAG1 FGF21 19481073 2102495 *induced* [Jag1] expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation JAG1 FGF21 19481073 2102553 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Positive_regulation JAG1 FGF22 19481073 2102496 *induced* [Jag1] expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation JAG1 FGF22 19481073 2102554 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Positive_regulation JAG1 FGF23 19481073 2102497 *induced* [Jag1] expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation JAG1 FGF23 19481073 2102555 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Positive_regulation JAG1 FGF3 19481073 2102498 *induced* [Jag1] expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation JAG1 FGF3 19481073 2102556 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Positive_regulation JAG1 FGF4 19481073 2102499 *induced* [Jag1] expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation JAG1 FGF4 19481073 2102557 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Positive_regulation JAG1 FGF4 24651014 2925930 Here , we show that produced by B cell lymphoma cells ( LCs ) through activating FGFR1 *upregulates* the Notch ligand [Jagged1 (Jag1)] on neighboring ECs . Positive_regulation JAG1 FGF5 19481073 2102500 *induced* [Jag1] expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation JAG1 FGF5 19481073 2102558 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Positive_regulation JAG1 FGF6 19481073 2102501 *induced* [Jag1] expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation JAG1 FGF6 19481073 2102559 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Positive_regulation JAG1 FGF7 19481073 2102502 *induced* [Jag1] expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation JAG1 FGF7 19481073 2102560 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Positive_regulation JAG1 FGF8 19481073 2102503 *induced* [Jag1] expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation JAG1 FGF8 19481073 2102561 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Positive_regulation JAG1 FGF9 19481073 2102504 *induced* [Jag1] expression and Notch2 signaling ( as judged by the appearance of activated Notch2 Intracellular Domain (N2ICD) ) within 12-24 h . Positive_regulation JAG1 FGF9 19481073 2102562 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Positive_regulation JAG1 GAST 15109306 1258467 EMSAs ( electrophoretic-mobility-shift assays ) using nuclear extracts of control and *stimulated* [AGS-G] ( R ) cells and a probe spanning -86 to -64 bp revealed multiple binding proteins . Positive_regulation JAG1 GAST 21193525 2469661 In Boyden chamber assays , recombinant PAI-1 inhibited *stimulated* [AGS-G] ( R ) cell migration and invasion , and small interfering RNA treatment increased responses to gastrin . Positive_regulation JAG1 HES5 12357247 994174 During mammalian central nervous system ( CNS ) development , contact mediated activation of Notch1 receptors on oligodendrocyte precursors by the ligand [Jagged1] *induces* , which inhibits maturation of these cells . Positive_regulation JAG1 HEY1 14976548 1213142 Here we report that expression of the hairy/enhancer-of-split related transcriptional repressor , and the Notch-ligand [Jagged1 (Jag1)] , was *induced* by TGF-beta at the onset of EMT in epithelial cells from mammary gland , kidney tubules , and epidermis . Positive_regulation JAG1 HEY1 14976548 1213147 The EMT phenotype , biphasic *activation* of , and delayed expression of [Jag1] were induced by TGF-beta in wild-type , but not in Smad3-deficient , primary mouse kidney tubular epithelial cells . Positive_regulation JAG1 HEY1 24651014 2925932 In turn , upregulation of [Jag1] on ECs reciprocally *induces* in LCs . Positive_regulation JAG1 HEY2 15389319 1300394 To clarify the *role* of in human CHD and [AGS] , we screened by direct sequencing 23 children with CHD and 38 patients diagnosed with AGS , which lack mutations in the JAG1 gene . Positive_regulation JAG1 HNRNPF 12798309 1098745 Immature internalized and processed the cell membrane components , and expressed M. leprae *derived* [antigens (Ags)] on their surface . Positive_regulation JAG1 HNRNPH1 12798309 1098746 Immature internalized and processed the cell membrane components , and expressed M. leprae *derived* [antigens (Ags)] on their surface . Positive_regulation JAG1 HOXD3 12836255 895752 *regulates* expression of [JAGGED1] , a ligand for Notch receptors . Positive_regulation JAG1 HOXD3 12836255 895754 Consequently , *promoted* expression of [JAGGED1] , a ligand for Notch receptors , in both the transfectants , suggesting that the JAGGED1 gene is a downstream target of HOXD3 . Positive_regulation JAG1 IFNA1 18461501 1840382 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Positive_regulation JAG1 IFNA10 18461501 1840383 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Positive_regulation JAG1 IFNA13 18461501 1840384 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Positive_regulation JAG1 IFNA14 18461501 1840385 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Positive_regulation JAG1 IFNA16 18461501 1840386 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Positive_regulation JAG1 IFNA17 18461501 1840387 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Positive_regulation JAG1 IFNA2 18461501 1840388 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Positive_regulation JAG1 IFNA21 18461501 1840389 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Positive_regulation JAG1 IFNA4 18461501 1840390 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Positive_regulation JAG1 IFNA5 18461501 1840391 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Positive_regulation JAG1 IFNA6 18461501 1840392 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Positive_regulation JAG1 IFNA7 18461501 1840393 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Positive_regulation JAG1 IFNA8 18461501 1840394 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Positive_regulation JAG1 IFNG 7963527 279417 is a potent *inducer* of class II MHC [Ags] on different cell types , including the astrocyte . Positive_regulation JAG1 IL12A 16823915 1581680 [AGs] also *induced* the production of and nitric oxide ( NO ) in the U937 human histiocyte and J774 mouse macrophage cell lines , respectively . Positive_regulation JAG1 IL12B 16823915 1581681 [AGs] also *induced* the production of and nitric oxide ( NO ) in the U937 human histiocyte and J774 mouse macrophage cell lines , respectively . Positive_regulation JAG1 IL1A 7963516 279403 Thus , our study shows that L. major infected M phi present [Ags] in a manner that augments Th2 T cell proliferation and IL-4 synthesis , and that the phenomenon is at least in part *mediated* by secreted by the infected M phi . Positive_regulation JAG1 IL1B 12912854 1129492 The same and H pylori concentrations induced comparable *increases* in [AGS] cell caseinolytic activity at 60 kDa . Positive_regulation JAG1 IL2 23319735 2738333 Finally , IVE-TB [Ags] *induced* strong IFN-? ( + ) /TNF-a ( + ) CD8 ( + ) and TNF-a ( + ) ( + ) CD154 ( + ) /CD4 ( + ) T cell responses in PBMC from long-term latently M. tuberculosis infected individuals . Positive_regulation JAG1 IL2 9780185 540506 We examined lymphocyte cell cycle kinetics , migration , expression of *activation* [Ags] ( CD69 and ) , cytokine production ( IL-2 , IL-4 , IFN-gamma ) , and apoptosis . Positive_regulation JAG1 IL2RA 8051398 267715 When cultured in the presence of previously activated T cells , up to 30 % of resting T cells are activated , as indicated by lymphoblastic morphology , formation of cell aggregates , expression of *activation* [Ags] ( and HLA-DR ) , and a proliferative response . Positive_regulation JAG1 IQGAP1 21537845 2440212 The transwell migration assay revealed that both and RhoC *stimulated* the migration activity of the gastric cancer cell line [AGS] . Positive_regulation JAG1 JAG2 21305512 2420043 In the annulus fibrosus , mRNA expression of the Notch ligand [Jagged1] was *induced* by hypoxia , while mRNA expression was highly sensitive to hypoxia in both tissues . Positive_regulation JAG1 LEP 21731759 2452118 Remarkably , *up-regulated* [Notch1-4/JAG1/Dll-4] , Notch target genes : Hey2 and survivin , together with IL-1 and VEGF/VEGFR-2 . Positive_regulation JAG1 MYLIP 21685392 2465433 Using miR-143/145 interfering oligonucleotides , we demonstrate that [Jag-1/Notch] signaling *requires* induction of both miR-143 and to promote the VSMC contractile phenotype . Positive_regulation JAG1 NELFCD 12218103 986437 Virgin T cells being primed to Th2 inducing or *inducing* [Ags] , respectively , start to synthesize IL-4 or IFN-gamma as they begin to proliferate . Positive_regulation JAG1 NELFCD 18354157 1887138 When the expression of different Notch ligands on DCs was analyzed , we found increased expression of Th2 promoting Jagged2 in TNF-DCs , whereas LPS+CD40-DCs up-regulated the *inducing* Delta4 and [Jagged1] molecules . Positive_regulation JAG1 NEURL 18077452 1862011 targeted to the plasma membrane by N-myristoylation *regulates* the Notch ligand [Jagged1] . Positive_regulation JAG1 NFKB1 10329626 613622 can trigger the Notch signaling pathway by *inducing* the expression of [Jagged1] , a ligand for Notch receptors . Positive_regulation JAG1 NFKB1 10329626 613632 Consistent with its *dependent* induction , [Jagged1] was found to be highly expressed in splenic B cells where c-Rel is expressed constitutively . Positive_regulation JAG1 NFKB1 19393188 2070142 These results indicate that canonical signaling is *required* for TNF induction of the notch ligand [jagged-1] in EC . Positive_regulation JAG1 NOTCH1 12357247 994175 During mammalian central nervous system ( CNS ) development , contact mediated *activation* of receptors on oligodendrocyte precursors by the ligand [Jagged1] induces Hes5 , which inhibits maturation of these cells . Positive_regulation JAG1 NOTCH1 12370358 995870 Our data suggest that *activation* of by [Jagged-1] plays an important role in maturation of human DCs . Positive_regulation JAG1 NOTCH1 17259973 1696709 Conversely , *activation* of by a soluble [jagged1] peptide leads to fewer tip cells and vessel branches . Positive_regulation JAG1 NOTCH1 17652726 1776197 The *activation* of by [Jagged1] resulted in the upregulation of active forms of Notch1 and 2 proteins ( P < 0.05 ) , with a concurrent increase in Ki67 ( P < 0.05 ) and a decrease in CK3 ( P < 0.05 ) expression . Positive_regulation JAG1 NOTCH1 18084619 1834605 Levels of erythropoietin receptor (EpoR) , CD24 , CD44 , [Jagged-1] expression , and *activation* of were assessed by flow cytometry . Positive_regulation JAG1 NOTCH1 18665263 1943069 Although both ligands were efficient in inducing Notch2 cleavage and activation in CD4 ( + ) T or reporter cells , the presence of Lunatic Fringe in CD4 ( + ) T cells inhibited [Jag1] *activation* of receptor . Positive_regulation JAG1 NOTCH1 19481073 2102435 signaling is *required* for lateral induction of [Jagged1] during FGF induced lens fiber differentiation . Positive_regulation JAG1 NOTCH1 19481073 2102589 These results demonstrate that *mediated* lateral induction of [Jag1] is an essential component of FGF dependent lens fiber cell differentiation . Positive_regulation JAG1 NOTCH1 20798046 2318193 Activation of in isolated nonsensory cells *results* in lateral induction of [Jag1] expression in neighboring cells and spreading of prosensory specification to the adjacent cells through an intercellular mechanism . Positive_regulation JAG1 NOTCH1 20870935 2337235 Strikingly , TLR induced [Jagged1] expression was strongly *dependent* on the Notch master transcriptional regulator RBP-J and also on upstream components of the Notch pathway ?-secretase and and Notch2 receptors . Positive_regulation JAG1 NOTCH1 20940224 2332856 Adult epidermal activity *induces* dermal accumulation of T cells and neural crest derivatives through upregulation of [jagged 1] . Positive_regulation JAG1 NOTCH1 20940224 2332864 Epidermal activation *resulted* in upregulation of [jagged 1] in both epidermis and dermis . Positive_regulation JAG1 NOTCH1 21078360 2376697 In addition , AMSCs expressed a high level of [Jagged-1] , which *induced* activation of signaling in T lymphocytes , thus reducing NF-?B activity . Positive_regulation JAG1 NOTCH1 21134038 2377824 ?-secretase inhibition of Notch resulted in increased epithelial cell layers , with recombinant [Jagged1] *activation* of leading to a reduction in epithelial cell layers during corneal wound healing . Positive_regulation JAG1 NOTCH1 21151194 2463377 Epithelial and stromal cell populations in the thymus express the Notch DSL ( Delta , Serrate and Lag2 ) ligands Delta-like 1 (Dll1) , Delta-like 4 (Dll4) , [Jagged 1] and Jagged 2 , and *induce* signalling in thymocytes that express the Notch receptor . Positive_regulation JAG1 NOTCH1 21266409 2380572 hJag1 activates , *induces* Hes/Hey genes and endogenous [Jag1] in a non-cell-autonomous manner , which is consistent with lateral induction . Positive_regulation JAG1 NOTCH1 21685392 2465397 *Activation* of signaling by [Jagged-1 (Jag-1)] in vascular smooth muscle cells ( VSMC ) promotes a differentiated phenotype characterized by increased expression of contractile proteins . Positive_regulation JAG1 NOTCH1 21685392 2465413 *Activation* of receptors by [Jag-1] caused CBF1 dependent up-regulation of miR-143/145 , increased differentiation , and decreased proliferation . Positive_regulation JAG1 NOTCH1 21712044 2460737 We also showed that the proliferative response of the neonatal cardiomyocytes involved the *activation* of receptor by its ligand [Jagged-1] expressed by the adjacent MSCs . Positive_regulation JAG1 NOTCH1 22147907 2536477 In vivo , we show that inhibition in cardiac neural crest *impairs* [Jagged1] messenger RNA expression and results in deficient smooth muscle differentiation and resultant aortic arch artery defects . Positive_regulation JAG1 NOTCH1 22330899 2576373 Constitutive activation of signaling was *sufficient* for the induction of Snai1 as well as Notch ligand [Jagged1] . Positive_regulation JAG1 NOTCH1 23752887 2801930 Renal involvement and the *role* of signalling in [Alagille syndrome] . Positive_regulation JAG1 NOTCH1 23965337 2845522 [Jag-1] *activation* of resulted in increased phosphorylation on serine 10 , decreased ubiquitination , and prolonged half-life of p27 ( kip1 ) . Positive_regulation JAG1 NOTCH1 23989801 2836401 In addition , *activation* of by [Jagged1] or administration of peroxynitrite scavenger reduced production of peroxynitrite and attenuated MI/R injury . Positive_regulation JAG1 NOTCH1 24140644 2868112 In conclusion , it seems that HCs fine-tune liver inflammation by upregulation of [Jagged1] and *activation* of signaling in Th1 cells . Positive_regulation JAG1 NOTCH1 25100656 2954306 We also tested *mediated* regulation of [Jag1] and Pax6 in the distal retina , to establish the appropriate context for Neurog2 patterning . Positive_regulation JAG1 NOTCH2 10958687 726166 Binding of Delta1 , [Jagged1] , and Jagged2 to Notch2 rapidly *induces* cleavage , nuclear translocation , and hyperphosphorylation of . Positive_regulation JAG1 NOTCH2 12370358 995871 Our data suggest that *activation* of by [Jagged-1] plays an important role in maturation of human DCs . Positive_regulation JAG1 NOTCH2 17259973 1696710 Conversely , *activation* of by a soluble [jagged1] peptide leads to fewer tip cells and vessel branches . Positive_regulation JAG1 NOTCH2 17652726 1776198 The *activation* of by [Jagged1] resulted in the upregulation of active forms of Notch1 and 2 proteins ( P < 0.05 ) , with a concurrent increase in Ki67 ( P < 0.05 ) and a decrease in CK3 ( P < 0.05 ) expression . Positive_regulation JAG1 NOTCH2 19481073 2102436 signaling is *required* for lateral induction of [Jagged1] during FGF induced lens fiber differentiation . Positive_regulation JAG1 NOTCH2 19481073 2102590 These results demonstrate that *mediated* lateral induction of [Jag1] is an essential component of FGF dependent lens fiber cell differentiation . Positive_regulation JAG1 NOTCH2 20798046 2318194 Activation of in isolated nonsensory cells *results* in lateral induction of [Jag1] expression in neighboring cells and spreading of prosensory specification to the adjacent cells through an intercellular mechanism . Positive_regulation JAG1 NOTCH2 20870935 2337236 Strikingly , TLR induced [Jagged1] expression was strongly *dependent* on the Notch master transcriptional regulator RBP-J and also on upstream components of the Notch pathway ?-secretase and Notch1 and receptors . Positive_regulation JAG1 NOTCH2 20940224 2332857 Adult epidermal activity *induces* dermal accumulation of T cells and neural crest derivatives through upregulation of [jagged 1] . Positive_regulation JAG1 NOTCH2 20940224 2332865 Epidermal activation *resulted* in upregulation of [jagged 1] in both epidermis and dermis . Positive_regulation JAG1 NOTCH2 21078360 2376698 In addition , AMSCs expressed a high level of [Jagged-1] , which *induced* activation of signaling in T lymphocytes , thus reducing NF-?B activity . Positive_regulation JAG1 NOTCH2 21134038 2377825 ?-secretase inhibition of Notch resulted in increased epithelial cell layers , with recombinant [Jagged1] *activation* of leading to a reduction in epithelial cell layers during corneal wound healing . Positive_regulation JAG1 NOTCH2 21151194 2463378 Epithelial and stromal cell populations in the thymus express the Notch DSL ( Delta , Serrate and Lag2 ) ligands Delta-like 1 (Dll1) , Delta-like 4 (Dll4) , [Jagged 1] and Jagged 2 , and *induce* signalling in thymocytes that express the Notch receptor . Positive_regulation JAG1 NOTCH2 21266409 2380573 hJag1 activates , *induces* Hes/Hey genes and endogenous [Jag1] in a non-cell-autonomous manner , which is consistent with lateral induction . Positive_regulation JAG1 NOTCH2 21685392 2465398 *Activation* of signaling by [Jagged-1 (Jag-1)] in vascular smooth muscle cells ( VSMC ) promotes a differentiated phenotype characterized by increased expression of contractile proteins . Positive_regulation JAG1 NOTCH2 21685392 2465414 *Activation* of receptors by [Jag-1] caused CBF1 dependent up-regulation of miR-143/145 , increased differentiation , and decreased proliferation . Positive_regulation JAG1 NOTCH2 22147907 2536478 In vivo , we show that inhibition in cardiac neural crest *impairs* [Jagged1] messenger RNA expression and results in deficient smooth muscle differentiation and resultant aortic arch artery defects . Positive_regulation JAG1 NOTCH2 22330899 2576374 Constitutive activation of signaling was *sufficient* for the induction of Snai1 as well as Notch ligand [Jagged1] . Positive_regulation JAG1 NOTCH2 23752887 2801931 Renal involvement and the *role* of signalling in [Alagille syndrome] . Positive_regulation JAG1 NOTCH2 23965337 2845523 [Jag-1] *activation* of resulted in increased phosphorylation on serine 10 , decreased ubiquitination , and prolonged half-life of p27 ( kip1 ) . Positive_regulation JAG1 NOTCH2 24140644 2868113 In conclusion , it seems that HCs fine-tune liver inflammation by upregulation of [Jagged1] and *activation* of signaling in Th1 cells . Positive_regulation JAG1 NOTCH2 24651014 2925933 In turn , upregulation of [Jag1] on ECs reciprocally *induces* in LCs . Positive_regulation JAG1 NOTCH2 25100656 2954307 We also tested *mediated* regulation of [Jag1] and Pax6 in the distal retina , to establish the appropriate context for Neurog2 patterning . Positive_regulation JAG1 NOTCH3 12370358 995872 Our data suggest that *activation* of by [Jagged-1] plays an important role in maturation of human DCs . Positive_regulation JAG1 NOTCH3 17259973 1696711 Conversely , *activation* of by a soluble [jagged1] peptide leads to fewer tip cells and vessel branches . Positive_regulation JAG1 NOTCH3 17652726 1776199 The *activation* of by [Jagged1] resulted in the upregulation of active forms of Notch1 and 2 proteins ( P < 0.05 ) , with a concurrent increase in Ki67 ( P < 0.05 ) and a decrease in CK3 ( P < 0.05 ) expression . Positive_regulation JAG1 NOTCH3 18060036 1833877 IL-6 treatment triggered *dependent* upregulation of the Notch ligand [Jagged-1] and promotion of MS and MCF-7 derived spheroid growth . Positive_regulation JAG1 NOTCH3 19150886 2038047 Furthermore , in mural cells , a dominant negative Mastermind-like1 construct inhibited expression , and endothelial expressed [JAGGED1] was *required* for its induction . Positive_regulation JAG1 NOTCH3 19150886 2038049 Additionally , we demonstrated that could *promote* its own expression and that of [JAGGED1] in mural cells . Positive_regulation JAG1 NOTCH3 19481073 2102437 signaling is *required* for lateral induction of [Jagged1] during FGF induced lens fiber differentiation . Positive_regulation JAG1 NOTCH3 19481073 2102591 These results demonstrate that mediated lateral *induction* of [Jag1] is an essential component of FGF dependent lens fiber cell differentiation . Positive_regulation JAG1 NOTCH3 20798046 2318195 Activation of in isolated nonsensory cells *results* in lateral induction of [Jag1] expression in neighboring cells and spreading of prosensory specification to the adjacent cells through an intercellular mechanism . Positive_regulation JAG1 NOTCH3 20940224 2332858 Adult epidermal activity *induces* dermal accumulation of T cells and neural crest derivatives through upregulation of [jagged 1] . Positive_regulation JAG1 NOTCH3 20940224 2332866 Epidermal activation *resulted* in upregulation of [jagged 1] in both epidermis and dermis . Positive_regulation JAG1 NOTCH3 21078360 2376699 In addition , AMSCs expressed a high level of [Jagged-1] , which *induced* activation of signaling in T lymphocytes , thus reducing NF-?B activity . Positive_regulation JAG1 NOTCH3 21134038 2377826 ?-secretase inhibition of Notch resulted in increased epithelial cell layers , with recombinant [Jagged1] *activation* of leading to a reduction in epithelial cell layers during corneal wound healing . Positive_regulation JAG1 NOTCH3 21151194 2463379 Epithelial and stromal cell populations in the thymus express the Notch DSL ( Delta , Serrate and Lag2 ) ligands Delta-like 1 (Dll1) , Delta-like 4 (Dll4) , [Jagged 1] and Jagged 2 , and *induce* signalling in thymocytes that express the Notch receptor . Positive_regulation JAG1 NOTCH3 21266409 2380574 hJag1 activates , *induces* Hes/Hey genes and endogenous [Jag1] in a non-cell-autonomous manner , which is consistent with lateral induction . Positive_regulation JAG1 NOTCH3 21685392 2465399 *Activation* of signaling by [Jagged-1 (Jag-1)] in vascular smooth muscle cells ( VSMC ) promotes a differentiated phenotype characterized by increased expression of contractile proteins . Positive_regulation JAG1 NOTCH3 21685392 2465415 *Activation* of receptors by [Jag-1] caused CBF1 dependent up-regulation of miR-143/145 , increased differentiation , and decreased proliferation . Positive_regulation JAG1 NOTCH3 22147907 2536479 In vivo , we show that inhibition in cardiac neural crest *impairs* [Jagged1] messenger RNA expression and results in deficient smooth muscle differentiation and resultant aortic arch artery defects . Positive_regulation JAG1 NOTCH3 22330899 2576375 Constitutive activation of signaling was *sufficient* for the induction of Snai1 as well as Notch ligand [Jagged1] . Positive_regulation JAG1 NOTCH3 23752887 2801932 Renal involvement and the *role* of signalling in [Alagille syndrome] . Positive_regulation JAG1 NOTCH3 23965337 2845524 [Jag-1] *activation* of resulted in increased phosphorylation on serine 10 , decreased ubiquitination , and prolonged half-life of p27 ( kip1 ) . Positive_regulation JAG1 NOTCH3 24140644 2868114 In conclusion , it seems that HCs fine-tune liver inflammation by upregulation of [Jagged1] and *activation* of signaling in Th1 cells . Positive_regulation JAG1 NOTCH3 25100656 2954308 We also tested *mediated* regulation of [Jag1] and Pax6 in the distal retina , to establish the appropriate context for Neurog2 patterning . Positive_regulation JAG1 NOTCH4 12370358 995873 Our data suggest that *activation* of by [Jagged-1] plays an important role in maturation of human DCs . Positive_regulation JAG1 NOTCH4 17259973 1696712 Conversely , *activation* of by a soluble [jagged1] peptide leads to fewer tip cells and vessel branches . Positive_regulation JAG1 NOTCH4 17652726 1776200 The *activation* of by [Jagged1] resulted in the upregulation of active forms of Notch1 and 2 proteins ( P < 0.05 ) , with a concurrent increase in Ki67 ( P < 0.05 ) and a decrease in CK3 ( P < 0.05 ) expression . Positive_regulation JAG1 NOTCH4 19481073 2102438 signaling is *required* for lateral induction of [Jagged1] during FGF induced lens fiber differentiation . Positive_regulation JAG1 NOTCH4 19481073 2102592 These results demonstrate that *mediated* lateral induction of [Jag1] is an essential component of FGF dependent lens fiber cell differentiation . Positive_regulation JAG1 NOTCH4 20798046 2318196 Activation of in isolated nonsensory cells *results* in lateral induction of [Jag1] expression in neighboring cells and spreading of prosensory specification to the adjacent cells through an intercellular mechanism . Positive_regulation JAG1 NOTCH4 20940224 2332859 Adult epidermal activity *induces* dermal accumulation of T cells and neural crest derivatives through upregulation of [jagged 1] . Positive_regulation JAG1 NOTCH4 20940224 2332867 Epidermal activation *resulted* in upregulation of [jagged 1] in both epidermis and dermis . Positive_regulation JAG1 NOTCH4 21078360 2376700 In addition , AMSCs expressed a high level of [Jagged-1] , which *induced* activation of signaling in T lymphocytes , thus reducing NF-?B activity . Positive_regulation JAG1 NOTCH4 21134038 2377827 ?-secretase inhibition of Notch resulted in increased epithelial cell layers , with recombinant [Jagged1] *activation* of leading to a reduction in epithelial cell layers during corneal wound healing . Positive_regulation JAG1 NOTCH4 21151194 2463380 Epithelial and stromal cell populations in the thymus express the Notch DSL ( Delta , Serrate and Lag2 ) ligands Delta-like 1 (Dll1) , Delta-like 4 (Dll4) , [Jagged 1] and Jagged 2 , and *induce* signalling in thymocytes that express the Notch receptor . Positive_regulation JAG1 NOTCH4 21266409 2380575 hJag1 activates , *induces* Hes/Hey genes and endogenous [Jag1] in a non-cell-autonomous manner , which is consistent with lateral induction . Positive_regulation JAG1 NOTCH4 21685392 2465400 *Activation* of signaling by [Jagged-1 (Jag-1)] in vascular smooth muscle cells ( VSMC ) promotes a differentiated phenotype characterized by increased expression of contractile proteins . Positive_regulation JAG1 NOTCH4 21685392 2465416 *Activation* of receptors by [Jag-1] caused CBF1 dependent up-regulation of miR-143/145 , increased differentiation , and decreased proliferation . Positive_regulation JAG1 NOTCH4 22147907 2536480 In vivo , we show that inhibition in cardiac neural crest *impairs* [Jagged1] messenger RNA expression and results in deficient smooth muscle differentiation and resultant aortic arch artery defects . Positive_regulation JAG1 NOTCH4 22330899 2576376 Constitutive activation of signaling was *sufficient* for the induction of Snai1 as well as Notch ligand [Jagged1] . Positive_regulation JAG1 NOTCH4 23752887 2801933 Renal involvement and the *role* of signalling in [Alagille syndrome] . Positive_regulation JAG1 NOTCH4 23965337 2845525 [Jag-1] *activation* of resulted in increased phosphorylation on serine 10 , decreased ubiquitination , and prolonged half-life of p27 ( kip1 ) . Positive_regulation JAG1 NOTCH4 24140644 2868115 In conclusion , it seems that HCs fine-tune liver inflammation by upregulation of [Jagged1] and *activation* of signaling in Th1 cells . Positive_regulation JAG1 NOTCH4 25100656 2954309 We also tested *mediated* regulation of [Jag1] and Pax6 in the distal retina , to establish the appropriate context for Neurog2 patterning . Positive_regulation JAG1 PIK3CA 25009698 2948407 Taken together , these findings indicate that the apoptotic activity of ß-lapachone is probably regulated by a caspase dependent cascade through activation of both intrinsic and extrinsic signaling pathways , and that inhibition of the signaling may *contribute* to ß-lapachone mediated [AGS] cell growth inhibition and apoptosis induction . Positive_regulation JAG1 PIK3R1 25009698 2948408 Taken together , these findings indicate that the apoptotic activity of ß-lapachone is probably regulated by a caspase dependent cascade through activation of both intrinsic and extrinsic signaling pathways , and that inhibition of the signaling may *contribute* to ß-lapachone mediated [AGS] cell growth inhibition and apoptosis induction . Positive_regulation JAG1 PRH1 15919063 1420404 These neurophysiological and microinjection findings support a critical *role* of in generation of this [AGS] kindling induced convulsive behavior . Positive_regulation JAG1 PRH2 15919063 1420405 These neurophysiological and microinjection findings support a critical *role* of in generation of this [AGS] kindling induced convulsive behavior . Positive_regulation JAG1 PTBP1 12798309 1098747 Immature internalized and processed the cell membrane components , and expressed M. leprae *derived* [antigens (Ags)] on their surface . Positive_regulation JAG1 PTBP2 12798309 1098744 Immature internalized and processed the cell membrane components , and expressed M. leprae *derived* [antigens (Ags)] on their surface . Positive_regulation JAG1 PTHLH 19587161 2105238 We found that *increased* Notch1 ligand [Jagged1] expression in human PDL cells in a dose- and time dependent manner . Positive_regulation JAG1 PTHLH 19587161 2105240 These results demonstrate that *induces* [Jagged1] expression in PDL cells , leading to osteo- and odontoclastogenesis , and thus likely promoting tooth and alveolar bone resorption . Positive_regulation JAG1 RBPJ 20870935 2337211 Autoamplification of Notch signaling in macrophages by TLR induced and dependent *induction* of [Jagged1] . Positive_regulation JAG1 RBPJ 20870935 2337234 Strikingly , TLR induced [Jagged1] expression was strongly *dependent* on the Notch master transcriptional regulator and also on upstream components of the Notch pathway ?-secretase and Notch1 and Notch2 receptors . Positive_regulation JAG1 REL 10329626 613623 can trigger the Notch signaling pathway by *inducing* the expression of [Jagged1] , a ligand for Notch receptors . Positive_regulation JAG1 REL 10329626 613625 Both and RelA *induced* [jagged1] gene expression , whereas a mutant defective for transactivation did not . Positive_regulation JAG1 REL 10329626 613633 Consistent with its *dependent* induction , [Jagged1] was found to be highly expressed in splenic B cells where c-Rel is expressed constitutively . Positive_regulation JAG1 REL 10329626 613638 These results demonstrate that can trigger the Notch signaling pathway in neighboring cells by *inducing* [jagged1] gene expression , and suggest a role for Jagged1 in B-cell activation , differentiation or function . Positive_regulation JAG1 RELA 10329626 613624 can trigger the Notch signaling pathway by *inducing* the expression of [Jagged1] , a ligand for Notch receptors . Positive_regulation JAG1 RELA 10329626 613626 Both c-Rel and *induced* [jagged1] gene expression , whereas a mutant defective for transactivation did not . Positive_regulation JAG1 RELA 10329626 613634 Consistent with its *dependent* induction , [Jagged1] was found to be highly expressed in splenic B cells where c-Rel is expressed constitutively . Positive_regulation JAG1 RELA 19393188 2070143 These results indicate that canonical signaling is *required* for TNF induction of the notch ligand [jagged-1] in EC . Positive_regulation JAG1 RHOC 21537845 2440213 The transwell migration assay revealed that both IQGAP1 and *stimulated* the migration activity of the gastric cancer cell line [AGS] . Positive_regulation JAG1 SEA 19019093 2093251 Inducible gene expression was modified by the presence of the macrophage growth factor colony stimulating factor (CSF)-1 , which inhibited [Jagged-1] *induction* by and LPS , but enhanced LPS induced IL-12p40 expression . Positive_regulation JAG1 SHH 17505514 1750940 Furthermore , overexpression *increased* the growth rate of the gastric cancer cell line , [AGS] . Positive_regulation JAG1 SKP1 10342559 616493 However , in the *presence* of alone , [Jagged1] increased erythroid colony formation twofold . Positive_regulation JAG1 SMAD3 20833210 2330853 Increased [Jagged1] expression upon TGFß1 exposure *required* signalling , and was also regulated by PI3K and ERK . Positive_regulation JAG1 TCF12 17568183 1815739 signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , [JAG1] and DKK1 genes . Positive_regulation JAG1 TCF15 17568183 1815740 signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , [JAG1] and DKK1 genes . Positive_regulation JAG1 TCF19 17568183 1815741 signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , [JAG1] and DKK1 genes . Positive_regulation JAG1 TCF20 17568183 1815742 signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , [JAG1] and DKK1 genes . Positive_regulation JAG1 TCF21 17568183 1815743 signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , [JAG1] and DKK1 genes . Positive_regulation JAG1 TCF23 17568183 1815754 signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , [JAG1] and DKK1 genes . Positive_regulation JAG1 TCF24 17568183 1815757 signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , [JAG1] and DKK1 genes . Positive_regulation JAG1 TCF25 17568183 1815756 signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , [JAG1] and DKK1 genes . Positive_regulation JAG1 TCF3 17568183 1815744 signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , [JAG1] and DKK1 genes . Positive_regulation JAG1 TCF4 17568183 1815745 signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , [JAG1] and DKK1 genes . Positive_regulation JAG1 TCF7 17568183 1815746 signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , [JAG1] and DKK1 genes . Positive_regulation JAG1 TGFB1 12039979 949577 *induces* renal epithelial [jagged-1] expression in fibrotic disease . Positive_regulation JAG1 TGFB1 12039979 949580 Recombinant human *increased* [jagged-1] mRNA levels at concentrations between 10 ( -11 ) and 10 ( -10 ) M . Positive_regulation JAG1 TGFB1 17980714 1874297 This led us to discover that ( TGFbeta1 ) , a primary driver of cellular changes in the kidney during nephropathy , *increased* Gremlin , [Jagged1] and Hes1 expression in human kidney epithelial cells . Positive_regulation JAG1 TGFB1 20169621 2242614 *induces* [Jagged1] expression in astrocytes via ALK5 and Smad3 and regulates the balance between oligodendrocyte progenitor proliferation and differentiation . Positive_regulation JAG1 TGFB1 20169621 2242615 In human astrocyte cultures , the cytokine *induced* [Jagged1] expression and blockade of the TGFbeta1 receptor kinase ALK5 abrogated Jagged1 induction . Positive_regulation JAG1 TGFB1 20169621 2242617 Collectively , these data illustrate the mechanisms underlying Jagged1 induction in human astrocytes , and suggest that *induced* activation of [Jagged1-Notch1] signaling may impact the size and differentiation of the OPC pool in the human CNS . Positive_regulation JAG1 TGFB2 12039979 949578 *induces* renal epithelial [jagged-1] expression in fibrotic disease . Positive_regulation JAG1 TGFB2 17980714 1874298 This led us to discover that ( TGFbeta1 ) , a primary driver of cellular changes in the kidney during nephropathy , *increased* Gremlin , [Jagged1] and Hes1 expression in human kidney epithelial cells . Positive_regulation JAG1 TGFB3 12039979 949579 *induces* renal epithelial [jagged-1] expression in fibrotic disease . Positive_regulation JAG1 TGFB3 17980714 1874299 This led us to discover that ( TGFbeta1 ) , a primary driver of cellular changes in the kidney during nephropathy , *increased* Gremlin , [Jagged1] and Hes1 expression in human kidney epithelial cells . Positive_regulation JAG1 THBS2 19147503 2043064 however , only *augments* the interaction between Notch3 and [Jagged1] . Positive_regulation JAG1 TLR1 18523256 1922783 Conversely , [Jagged1] expression is markedly *induced* by ligation . Positive_regulation JAG1 TLR1 20870935 2337224 Strikingly , *induced* [Jagged1] expression was strongly dependent on the Notch master transcriptional regulator RBP-J and also on upstream components of the Notch pathway ?-secretase and Notch1 and Notch2 receptors . Positive_regulation JAG1 TLR10 18523256 1922791 Conversely , [Jagged1] expression is markedly *induced* by ligation . Positive_regulation JAG1 TLR10 20870935 2337232 Strikingly , *induced* [Jagged1] expression was strongly dependent on the Notch master transcriptional regulator RBP-J and also on upstream components of the Notch pathway ?-secretase and Notch1 and Notch2 receptors . Positive_regulation JAG1 TLR2 18523256 1922784 Conversely , [Jagged1] expression is markedly *induced* by ligation . Positive_regulation JAG1 TLR2 20870935 2337225 Strikingly , *induced* [Jagged1] expression was strongly dependent on the Notch master transcriptional regulator RBP-J and also on upstream components of the Notch pathway ?-secretase and Notch1 and Notch2 receptors . Positive_regulation JAG1 TLR2 22467654 2583245 Thus , NK cells stimulated by *activating* HSV [Ags] can present Ag alone or augment the role of DCs in vitro and perhaps in herpetic lesions or draining lymph nodes . Positive_regulation JAG1 TLR3 18523256 1922785 Conversely , [Jagged1] expression is markedly *induced* by ligation . Positive_regulation JAG1 TLR3 20870935 2337226 Strikingly , *induced* [Jagged1] expression was strongly dependent on the Notch master transcriptional regulator RBP-J and also on upstream components of the Notch pathway ?-secretase and Notch1 and Notch2 receptors . Positive_regulation JAG1 TLR4 18523256 1922786 Conversely , [Jagged1] expression is markedly *induced* by ligation . Positive_regulation JAG1 TLR4 20870935 2337227 Strikingly , *induced* [Jagged1] expression was strongly dependent on the Notch master transcriptional regulator RBP-J and also on upstream components of the Notch pathway ?-secretase and Notch1 and Notch2 receptors . Positive_regulation JAG1 TLR5 18523256 1922787 Conversely , [Jagged1] expression is markedly *induced* by ligation . Positive_regulation JAG1 TLR5 20870935 2337228 Strikingly , *induced* [Jagged1] expression was strongly dependent on the Notch master transcriptional regulator RBP-J and also on upstream components of the Notch pathway ?-secretase and Notch1 and Notch2 receptors . Positive_regulation JAG1 TLR6 18523256 1922792 Conversely , [Jagged1] expression is markedly *induced* by ligation . Positive_regulation JAG1 TLR6 20870935 2337233 Strikingly , *induced* [Jagged1] expression was strongly dependent on the Notch master transcriptional regulator RBP-J and also on upstream components of the Notch pathway ?-secretase and Notch1 and Notch2 receptors . Positive_regulation JAG1 TLR7 18523256 1922788 Conversely , [Jagged1] expression is markedly *induced* by ligation . Positive_regulation JAG1 TLR7 20870935 2337229 Strikingly , *induced* [Jagged1] expression was strongly dependent on the Notch master transcriptional regulator RBP-J and also on upstream components of the Notch pathway ?-secretase and Notch1 and Notch2 receptors . Positive_regulation JAG1 TLR8 18523256 1922789 Conversely , [Jagged1] expression is markedly *induced* by ligation . Positive_regulation JAG1 TLR8 20870935 2337230 Strikingly , *induced* [Jagged1] expression was strongly dependent on the Notch master transcriptional regulator RBP-J and also on upstream components of the Notch pathway ?-secretase and Notch1 and Notch2 receptors . Positive_regulation JAG1 TLR9 18523256 1922790 Conversely , [Jagged1] expression is markedly *induced* by ligation . Positive_regulation JAG1 TLR9 20870935 2337231 Strikingly , *induced* [Jagged1] expression was strongly dependent on the Notch master transcriptional regulator RBP-J and also on upstream components of the Notch pathway ?-secretase and Notch1 and Notch2 receptors . Positive_regulation JAG1 TNF 11587542 866535 In TSU-Pr1 and T24 ( oncogenic Ras cell lines ) , TNF-alpha suppresses cell cycle progression without induction of apoptosis , whereas [AGS] ( wild-type Ras ) is *stimulated* in its cell cycle by coupled with activation of Erk . Positive_regulation JAG1 TNF 18337563 1904878 Notch signaling regulates tip cell function , and we find that also *induces* the notch ligand [jagged-1] , through an NFkappaB dependent mechanism . Positive_regulation JAG1 TNF 19393188 2070137 *induction* of [jagged-1] in endothelial cells is NFkappaB dependent . Positive_regulation JAG1 TNF 19393188 2070138 Here we demonstrate that *induction* of [jagged-1] in human EC is rapid and dependent upon signaling through TNFR1 , but not TNFR2 . Positive_regulation JAG1 TNF 19393188 2070141 These results indicate that canonical NFkappaB signaling is required for *induction* of the notch ligand [jagged-1] in EC . Positive_regulation JAG1 TNF 23319735 2738328 Finally , IVE-TB [Ags] *induced* strong IFN-? ( + ) ( + ) CD8 ( + ) and TNF-a ( + ) /IL-2 ( + ) CD154 ( + ) /CD4 ( + ) T cell responses in PBMC from long-term latently M. tuberculosis infected individuals . Positive_regulation JAG1 TNFRSF8 8568238 350952 In short-term culture , expression could be *induced* on T cells by [Ags] that elicit Th2-type responses ( Schistosoma haematobium , adult worm Ag , and Toxocaria canis , excretory/secretory Ag ) and Th0-type responses ( tetanus toxoid ) , as well as Th1-type responses ( tuberculin purified protein derivative ) . Positive_regulation JAG1 TNFSF11 18710934 1968156 In the present study , we show that *induces* expression of [Jagged1] and Notch2 in bone marrow macrophages during osteoclast differentiation . Positive_regulation JAG1 WNT1 17143565 1668164 Canonical signaling to intestinal progenitor cells *leads* to transcriptional activation of the [JAG1] gene , encoding Serrate-type Notch ligand . Positive_regulation JAG1 WNT1 17568183 1815747 signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , [JAG1] and DKK1 genes . Positive_regulation JAG1 WNT1 20953350 2357227 We also found that inhibition of signaling *reduced* [Jagged1] expression , and co-administration of shRNAs targeting both Notch3 and ß-catenin reduced Jagged1 expression much more than targeting either individual gene . Positive_regulation JAG1 WNT1 20953350 2357234 In addition , pathway activation also *up-regulated* [Jagged1] . Positive_regulation JAG1 WNT11 17143565 1668165 Canonical signaling to intestinal progenitor cells *leads* to transcriptional activation of the [JAG1] gene , encoding Serrate-type Notch ligand . Positive_regulation JAG1 WNT11 17568183 1815748 signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , [JAG1] and DKK1 genes . Positive_regulation JAG1 WNT11 20953350 2357228 We also found that inhibition of signaling *reduced* [Jagged1] expression , and co-administration of shRNAs targeting both Notch3 and ß-catenin reduced Jagged1 expression much more than targeting either individual gene . Positive_regulation JAG1 WNT11 20953350 2357235 In addition , pathway activation also *up-regulated* [Jagged1] . Positive_regulation JAG1 WNT16 17143565 1668170 Canonical signaling to intestinal progenitor cells *leads* to transcriptional activation of the [JAG1] gene , encoding Serrate-type Notch ligand . Positive_regulation JAG1 WNT16 17568183 1815753 signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , [JAG1] and DKK1 genes . Positive_regulation JAG1 WNT16 20953350 2357233 We also found that inhibition of signaling *reduced* [Jagged1] expression , and co-administration of shRNAs targeting both Notch3 and ß-catenin reduced Jagged1 expression much more than targeting either individual gene . Positive_regulation JAG1 WNT16 20953350 2357240 In addition , pathway activation also *up-regulated* [Jagged1] . Positive_regulation JAG1 WNT2 17143565 1668166 Canonical signaling to intestinal progenitor cells *leads* to transcriptional activation of the [JAG1] gene , encoding Serrate-type Notch ligand . Positive_regulation JAG1 WNT2 17568183 1815749 signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , [JAG1] and DKK1 genes . Positive_regulation JAG1 WNT2 20953350 2357229 We also found that inhibition of signaling *reduced* [Jagged1] expression , and co-administration of shRNAs targeting both Notch3 and ß-catenin reduced Jagged1 expression much more than targeting either individual gene . Positive_regulation JAG1 WNT2 20953350 2357236 In addition , pathway activation also *up-regulated* [Jagged1] . Positive_regulation JAG1 WNT3 17143565 1668167 Canonical signaling to intestinal progenitor cells *leads* to transcriptional activation of the [JAG1] gene , encoding Serrate-type Notch ligand . Positive_regulation JAG1 WNT3 17568183 1815750 signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , [JAG1] and DKK1 genes . Positive_regulation JAG1 WNT3 20953350 2357230 We also found that inhibition of signaling *reduced* [Jagged1] expression , and co-administration of shRNAs targeting both Notch3 and ß-catenin reduced Jagged1 expression much more than targeting either individual gene . Positive_regulation JAG1 WNT3 20953350 2357237 In addition , pathway activation also *up-regulated* [Jagged1] . Positive_regulation JAG1 WNT4 17143565 1668168 Canonical signaling to intestinal progenitor cells *leads* to transcriptional activation of the [JAG1] gene , encoding Serrate-type Notch ligand . Positive_regulation JAG1 WNT4 17568183 1815751 signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , [JAG1] and DKK1 genes . Positive_regulation JAG1 WNT4 20953350 2357231 We also found that inhibition of signaling *reduced* [Jagged1] expression , and co-administration of shRNAs targeting both Notch3 and ß-catenin reduced Jagged1 expression much more than targeting either individual gene . Positive_regulation JAG1 WNT4 20953350 2357238 In addition , pathway activation also *up-regulated* [Jagged1] . Positive_regulation JAG1 WNT4 23560082 2767611 These results demonstrate that [Jagged1-Notch1] signaling in endocardial cells *induces* the expression of , which subsequently acts as a paracrine factor to upregulate Bmp2 expression in the adjacent AVC myocardium to signal EMT . Positive_regulation JAG1 WNT6 17143565 1668169 Canonical signaling to intestinal progenitor cells *leads* to transcriptional activation of the [JAG1] gene , encoding Serrate-type Notch ligand . Positive_regulation JAG1 WNT6 17568183 1815752 signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , [JAG1] and DKK1 genes . Positive_regulation JAG1 WNT6 20953350 2357232 We also found that inhibition of signaling *reduced* [Jagged1] expression , and co-administration of shRNAs targeting both Notch3 and ß-catenin reduced Jagged1 expression much more than targeting either individual gene . Positive_regulation JAG1 WNT6 20953350 2357239 In addition , pathway activation also *up-regulated* [Jagged1] . Positive_regulation JAG2 TNF 14586405 1159560 We found that *induced* the expression of Notch-1 , Notch-4 , and [Jagged-2] in RSF . Positive_regulation JAK1 EPHB2 12955078 1137684 Further biochemical analyses revealed that IL-3 *induced* [Jak/Stat] , , and PI3 kinase pathways in SHP-2 ( -/- ) cells were impaired and reintroduction of WT SHP-2 into mutant cells partially restored IL-3 signaling . Positive_regulation JAK1 EPHB2 19508391 2108579 Effects of tripterine were investigated on endothelial barrier function , inducible nitric oxide synthase (iNOS) expression , nicotinamide adenine dinucleotide phasphate ( NADPH) oxidase activity , 3-nitrotyrosine formation , protein phosphatase type 2A (PP2A) activity , *activation* of , c-Jun terminal kinase (JNK) and [Janus kinase] ( Jak2 ) , and degradation of IkappaB in microvascular endothelial cells exposed to pro-inflammatory stimulus [ lipopolysaccharide (LPS) + interferon gamma (IFNgamma) ] and on vascular permeability in air pouches of mice injected with LPS + IFNgamma . Positive_regulation JAK1 IL1B 19834007 2164909 Promoter analysis showed that stretch mediated *activates* [JAK/STAT] to transcriptionally regulate the IGF-1 gene . Positive_regulation JAK1 JAG1 24115357 2896441 We show that the transplantation of hESC derived OPC and MP promotes astrogliosis , through activation of *dependent* Notch and [Jak/STAT] signaling that support axonal survival . Positive_regulation JAK1 TNF 10347215 616825 Herein , we demonstrate that the ability of IL-10 to inhibit production in lipopolysaccharide stimulated macrophages *requires* the presence of Stat3 , [Jak1] , and two distinct regions of the IL-10 receptor intracellular domain . Positive_regulation JAK1 TNF 11801527 902544 *activates* [Jak1/Stat3-Stat5B] signaling through TNFR-1 in human B cells . Positive_regulation JAK1 TNF 11801527 902548 Here we present evidence that *induces* the activation of the cytoplasmic Janus tyrosine kinases [Jak1] and Tyk2 in both human healthy peripheral and lymphoma B cells . Positive_regulation JAK1 TNF 15087472 1258131 Stimulatory effects of on neuropeptide gene expression and release appeared to be mediated through the type 2 TNF-alpha receptor , and *required* activation of ERK 1/2 and p38 , but not [Janus kinase] , MAPKs . Positive_regulation JAK1 TNF 23170143 2700356 Recent studies have shown that cerulein activated nicotinamide adenine dinucleotide phosphate oxidase elicits reactive oxygen species , which trigger the phosphorylation of the [JAK1] , STAT1 , and STAT3 proteins and *induce* the production of inflammatory cytokines , such as , interleukin (IL)-1ß , and IL-6 , in pancreatic acinar cells . Positive_regulation JAK1 TNF 9510175 491841 *Induction* of [Jak/STAT] signaling by activation of the type 1 receptor . Positive_regulation JAK1 TNF 9510175 491848 In this study , we show that murine *induces* the tyrosine phosphorylation and activation of the intracellular Janus tyrosine kinases [Jak1] , Jak2 , and Tyk2 in murine 3T3-L1 adipocytes . Positive_regulation JAK1 TNF 9510175 491851 Phosphorylation of [Jak] proteins was also *induced* by human , which selectively binds to TNFR1 on murine cells . Positive_regulation JAK2 CTGF 23108098 2721410 Taken together , these results indicate that thrombin might activate c-Src to induce [JAK2] activation , which in turn , causes STAT3 activation , and finally *induces* expression in human lung fibroblasts . Positive_regulation JAK2 EPHB2 12955078 1137686 Further biochemical analyses revealed that IL-3 *induced* [Jak/Stat] , , and PI3 kinase pathways in SHP-2 ( -/- ) cells were impaired and reintroduction of WT SHP-2 into mutant cells partially restored IL-3 signaling . Positive_regulation JAK2 EPHB2 19508391 2108580 Effects of tripterine were investigated on endothelial barrier function , inducible nitric oxide synthase (iNOS) expression , nicotinamide adenine dinucleotide phasphate ( NADPH) oxidase activity , 3-nitrotyrosine formation , protein phosphatase type 2A (PP2A) activity , *activation* of , c-Jun terminal kinase (JNK) and [Janus kinase] ( Jak2 ) , and degradation of IkappaB in microvascular endothelial cells exposed to pro-inflammatory stimulus [ lipopolysaccharide (LPS) + interferon gamma (IFNgamma) ] and on vascular permeability in air pouches of mice injected with LPS + IFNgamma . Positive_regulation JAK2 FOXO1 22941110 2678496 Leptin promoted the physical interaction of JAK2 and ROCK1 , thereby increasing phosphorylation of [JAK2] and downstream *activation* of Stat3 and . Positive_regulation JAK2 IL1B 19834007 2164910 Promoter analysis showed that stretch mediated *activates* [JAK/STAT] to transcriptionally regulate the IGF-1 gene . Positive_regulation JAK2 JAG1 24115357 2896442 We show that the transplantation of hESC derived OPC and MP promotes astrogliosis , through activation of *dependent* Notch and [Jak/STAT] signaling that support axonal survival . Positive_regulation JAK2 S100B 12941779 1133506 *mediated* augmentation of angiotensin II-induced activation of [JAK2] in vascular smooth muscle cells is dependent on PLD2 . Positive_regulation JAK2 S100B 12941779 1133508 We also found that interaction *triggered* intracellular generation of reactive oxygen species ( ROS ) , VSMC proliferation , and [JAK2] tyrosine phosphorylation via activation of phospholipase D (PLD)2 . Positive_regulation JAK2 S100B 12941779 1133510 These results provide direct evidence for linkages between PLD2 , ROS production , and *induced* enhancement of Ang II-induced cell proliferation and activation of [JAK2] in VSMCs . Positive_regulation JAK2 TNF 10454343 637716 In TNF-alpha treated cells , IFN-gamma induced phosphorylation of Jak2 kinase is increased , Jak2 kinase activity is enhanced , and genetic studies indicate that *requires* [Jak2] kinase activity to enhance Stat1alpha tyrosine phosphorylation . Positive_regulation JAK2 TNF 15087472 1258132 Stimulatory effects of on neuropeptide gene expression and release appeared to be mediated through the type 2 TNF-alpha receptor , and *required* activation of ERK 1/2 and p38 , but not [Janus kinase] , MAPKs . Positive_regulation JAK2 TNF 24441870 2922928 We showed that markedly *stimulated* [Jak2] , PDGFR , Akt , and p42/p44 MAPK phosphorylation , which were attenuated by their respective inhibitors . Positive_regulation JAK2 TNF 9510175 491842 *Induction* of [Jak/STAT] signaling by activation of the type 1 receptor . Positive_regulation JAK2 TNF 9510175 491849 In this study , we show that murine *induces* the tyrosine phosphorylation and activation of the intracellular Janus tyrosine kinases Jak1 , [Jak2] , and Tyk2 in murine 3T3-L1 adipocytes . Positive_regulation JAK2 TNF 9510175 491852 Phosphorylation of [Jak] proteins was also *induced* by human , which selectively binds to TNFR1 on murine cells . Positive_regulation JAK3 EPHB2 12955078 1137688 Further biochemical analyses revealed that IL-3 *induced* [Jak/Stat] , , and PI3 kinase pathways in SHP-2 ( -/- ) cells were impaired and reintroduction of WT SHP-2 into mutant cells partially restored IL-3 signaling . Positive_regulation JAK3 EPHB2 19508391 2108581 Effects of tripterine were investigated on endothelial barrier function , inducible nitric oxide synthase (iNOS) expression , nicotinamide adenine dinucleotide phasphate ( NADPH) oxidase activity , 3-nitrotyrosine formation , protein phosphatase type 2A (PP2A) activity , *activation* of , c-Jun terminal kinase (JNK) and [Janus kinase] ( Jak2 ) , and degradation of IkappaB in microvascular endothelial cells exposed to pro-inflammatory stimulus [ lipopolysaccharide (LPS) + interferon gamma (IFNgamma) ] and on vascular permeability in air pouches of mice injected with LPS + IFNgamma . Positive_regulation JAK3 IL1B 19834007 2164911 Promoter analysis showed that stretch mediated *activates* [JAK/STAT] to transcriptionally regulate the IGF-1 gene . Positive_regulation JAK3 JAG1 24115357 2896443 We show that the transplantation of hESC derived OPC and MP promotes astrogliosis , through activation of *dependent* Notch and [Jak/STAT] signaling that support axonal survival . Positive_regulation JAK3 TNF 15087472 1258133 Stimulatory effects of on neuropeptide gene expression and release appeared to be mediated through the type 2 TNF-alpha receptor , and *required* activation of ERK 1/2 and p38 , but not [Janus kinase] , MAPKs . Positive_regulation JAK3 TNF 9510175 491843 *Induction* of [Jak/STAT] signaling by activation of the type 1 receptor . Positive_regulation JAK3 TNF 9510175 491853 Phosphorylation of [Jak] proteins was also *induced* by human , which selectively binds to TNFR1 on murine cells . Positive_regulation JUN AGR2 15879121 1406020 Phosphorylation of Y775 did not depend on the other tyrosines , and point mutation of PLCgamma1 Y775 , or the previously described Y783 , substantially reduced induced calcium , NF-AT , and [AP-1] *activation* . Positive_regulation JUN AXIN2 12192039 980770 The overexpression of HIC but not I-mfa decreased the inhibitory effects of Axin on beta-catenin regulated reporter constructs , while both HIC and I-mfa decreased mediated [c-Jun N-terminal kinase (JNK)] *activation* . Positive_regulation JUN CCND1 10340380 616153 This suggests that both early and late [AP-1] gene expression is regulated by the same Gi-mediated , MEK dependent MAPK signalling pathway but that expression of late AP-1 genes and *requires* that this pathway be persistently activated . Positive_regulation JUN CCND1 11984522 935674 Accordingly , we found that S-adenosylmethionine inhibits hepatocyte growth factor induced and D2 expression , [activator protein 1] *induction* , and hepatocyte proliferation . Positive_regulation JUN CCND1 16393119 1494455 We concluded that the inhibitory effect of eupatilin on p21waf1/Cip1 expression is likely to be associated with the downregulation of expression and [AP-1] *activation* , which play an important role in the cell cycle arrest of ras transformed breast epithelial cells . Positive_regulation JUN CCND1 21847632 2524290 We found that , in lung cancer cell lines and in nude mice , Interleukin-7/Interleukin-7 receptor increased the expression of and phosphorylation of c-Fos/c-Jun , *induce* c-Fos and [c-Jun] heterodimer formation , and enhanced c-Fos/c-Jun DNA binding activity to regulate cyclin D1 . Positive_regulation JUN CTGF 18836231 1971259 When a human chondrocytic cell line , HCS-2/8 was exposed to uni-axial cyclic mechanical force ( 6 % elongation , 10 times/min ) only for 30 min , the expression level of ( CCN2 ) increased , and [c-Jun N-terminal protein kinase (JNK)] was *activated* . Positive_regulation JUN CTGF 19820199 2164611 The expression of profibrotic factors , transforming growth factor-beta ( TGF-beta1 ) , , and matrix proteins was increased , and the TGF-beta1 linked transcription factors phospho-Smad3/4 and [activator protein-1] were *activated* in the DM1 myocardium . Positive_regulation JUN CTGF 22212430 2531474 Thrombin acts on PAR-1 to activate the JNK signaling pathway , which in turn initiates [AP-1] activation and ultimately *induces* expression in VSMCs . Positive_regulation JUN CTGF 23227240 2708236 *mediated* increase of NF-?B and [AP-1] luciferase activity was inhibited by SB203580 and SP600125 or ASK1 shRNA or p38 and JNK mutant . Positive_regulation JUN CTGF 23274856 2758059 mediated *increase* of NF-?B and [AP-1] luciferase activity was inhibited by FAK , MEK , and ERK inhibitors or mutants . Positive_regulation JUN CTGF 23681229 2785474 Our studies are the first to demonstrate that reduced as an unfavorable prognosis factor *mediates* the activation of miR-18b , an oncomir directly suppresses CTGF expression , by [PI3K/AKT/C-Jun] and C-Myc and promotes cell growth of NPC . Positive_regulation JUN CTGF 23906792 2866078 *caused* increases in [c-Jun] phosphorylation and the recruitment of c-Jun and c-Fos to the collagen I promoter . Positive_regulation JUN CTGF 23906792 2866080 Furthermore , stimulation of cells with the *resulted* in increases in [AP-1-luciferase] activity ; Positive_regulation JUN EDN2 10187821 602960 several exhibited greatly decreased AP-1 activity , relative to wild type ETB , whereas others displayed augmented *stimulated* [AP-1] transcriptional activity relative to wild type ETB . Positive_regulation JUN EPHB2 10585423 571346 This AP-1 activation was completely blocked by PD 098059 , a specific mitogen activated protein kinase/ERK kinase inhibitor , as well as by a dominant negative JNK or a dominant negative Jun , indicating that the [AP-1] activation induced by 1,25 ( OH ) ( 2 ) D ( 3 ) was *mediated* by and JNK . Positive_regulation JUN EPHB2 10601128 574189 Tumor necrosis factor-alpha (TNF-alpha) alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 MAPK , and [c-Jun] N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only . Positive_regulation JUN EPHB2 10748108 690857 Inhibition of by the mitogen activated protein kinase/ERK kinase inhibitor PD 98059 or by expression of a dominant negative mutant ERK *suppressed* [AP-1] activation . Positive_regulation JUN EPHB2 10862759 722252 [AP-1] binding was *dependent* on activation , since the MEK-1 ( mitogen activated protein kinase kinase ) inhibitor PD98059 inhibited TGF-beta1 induced binding . Positive_regulation JUN EPHB2 10984494 752151 Strain increased *dependent* [AP-1] nuclear protein binding , which was attenuated by cytochalasin D and 8-Br-cGMP . Positive_regulation JUN EPHB2 11695993 877175 The [AP-1] stimulation appeared to be *mediated* by but not JNK or p38 signalling pathways , because all NAEs stimulated ERK1/ERK2 phosphorylation without having any effect on JNK or p38 kinases . Positive_regulation JUN EPHB2 11756554 899157 These observations suggest that dependent activation of Fra-1 is *required* for [AP-1] transactivation in JB6 cells . Positive_regulation JUN EPHB2 11884386 929816 JNK is involved in c-Jun phosphorylation , whereas and p38 activities are *essential* for maximal c-Jun and Fra-2 expression , and [AP-1] DNA binding activity . Positive_regulation JUN EPHB2 11914583 925224 These results indicate that PMA treatment *induced* activation mainly through the Raf-MEK-ERK signaling pathway following induction of c-Jun expression , and the formation of the [c-Jun-Sp1] complex . Positive_regulation JUN EPHB2 12057768 952192 Together these data suggest that C5a mediated [AP-1] activation *requires* both the activation of the and JNK pathways , whereas activation of the JNK pathway is sufficient to increase AP-1 binding with ADP . Positive_regulation JUN EPHB2 12070163 975852 Overexpression studies in Jurkat T cells indicate that DGKzeta interferes with TCR induced Ras and activation , [AP-1] *induction* , and expression of the activation marker CD69 . Positive_regulation JUN EPHB2 12186939 979744 The phosphorylation could be inhibited by the ERK pathway inhibitor PD98059 , indicating that may *contribute* to the phosphorylation of [c-Jun] in LMP2A expressing cells . Positive_regulation JUN EPHB2 12424250 1036493 ATP failed to stimulate the phosphorylation of and c-Jun N-terminal kinase and *activation* of [AP-1] in the p56 ( lck ) -deficient isogenic T cell line JCaM1 , suggesting a critical role for p56 ( lck ) kinase in downstream signaling . Positive_regulation JUN EPHB2 12514175 1063809 activation *induced* [c-Jun] , a member of the AP-1 transcription factor family . Positive_regulation JUN EPHB2 12594266 1060837 Interestingly , transient activation *resulted* in altered [AP-1] DNA binding activity and the induction of an AP-1 complex that was devoid of Fos protein and consisted of Jun-Jun dimers . Positive_regulation JUN EPHB2 14625389 1170182 We show that [c-JUN] and FRA-1 expression is *dependent* on activity and that different thresholds of ERK activity control the expression of FRA-1 . Positive_regulation JUN EPHB2 14729583 1235006 In order to clarify the *roles* of p38 and in TPA induced [AP-1] activation , we utilized the pharmacologic inhibitors of these enzymes . Positive_regulation JUN EPHB2 15005710 1217477 In contrast , concomitant stimulation of the STAT3 signal and a markedly *increased* [AP-1] activity with enhanced c-Fos expression . Positive_regulation JUN EPHB2 15063796 1231000 These studies show that in mouse keratinocytes MMP-13 gene expression can be induced through a Runx independent pathway that involves the *dependent* modulation of [AP-1] . Positive_regulation JUN EPHB2 15129224 1258685 HQ also induces *dependent* [AP-1] activation with concomitant increased transcriptional activity of AP-1 reporter gene . Positive_regulation JUN EPHB2 15253728 1271691 *induces* increases in [activator protein-1 (AP-1)] transcription factor activity which may augment mesangial cell proliferation and ECM protein production . Positive_regulation JUN EPHB2 15886210 1433046 The [AP-1] stimulation appeared to be *mediated* by but not JNK or p38 kinase . Positive_regulation JUN EPHB2 16051824 1438639 Several MAPK regulated host transcription factors such as c-Jun , STAT1alpha , MEF2 , c-Myc , ATF-2 and c-Fos were induced early during infection , and inhibition significantly *blocked* the c-Fos , [c-Jun] , c-Myc , and STAT1alpha activation in the infected cells . Positive_regulation JUN EPHB2 17111371 1667729 Here we studied the activation of [AP-1] proteins in *response* to , JNK , and p38 signaling upon NGF , EGF and anisomycin exposures . Positive_regulation JUN EPHB2 17111371 1667750 While inhibition of the , JNK , and p38 activities partially *prevented* [AP-1] activity and suppressed differentiation , none of them was required for anisomycin induced apoptosis . Positive_regulation JUN EPHB2 17116726 1724520 Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the *dependent* [c-Jun/AP-1] induction of MMP-2 . Positive_regulation JUN EPHB2 17921324 1830337 Our data indicate that IL-17 induces MMP-1 in human cardiac fibroblasts directly via p38 MAPK- and *dependent* [AP-1] , NF-kappaB , and C/EBP-beta activation and suggest that IL-17 may play a critical role in myocardial remodeling . Positive_regulation JUN EPHB2 18093576 1868707 We observed that and JNK , but not p38 MAP kinase , are *involved* in BPDE induced [AP-1] activation . Positive_regulation JUN EPHB2 18435914 1908199 signaling regulates tumor promoter *induced* [c-Jun] recruitment at the Fra-1 promoter . Positive_regulation JUN EPHB2 18982426 2105742 These inhibitory effects were partially inhibited by SB203580 , a specific inhibitor of p38 MAPK , but not by PD98059 , a specific *inhibitors* of extracellular signal regulated kinase ( ) , and SP600125 , a specific inhibitor of [c-Jun-N-terminal kinase (JNK)] . Positive_regulation JUN EPHB2 19190345 2039002 signaling *induces* [JUN/activator] protein 1 activation , which is essential for oncogenic transformation , in combination with the GLI activator forms GLI1 and GLI2 . Positive_regulation JUN EPHB2 19508391 2108582 Effects of tripterine were investigated on endothelial barrier function , inducible nitric oxide synthase (iNOS) expression , nicotinamide adenine dinucleotide phasphate ( NADPH) oxidase activity , 3-nitrotyrosine formation , protein phosphatase type 2A (PP2A) activity , *activation* of , [c-Jun terminal kinase (JNK)] and Janus kinase ( Jak2 ) , and degradation of IkappaB in microvascular endothelial cells exposed to pro-inflammatory stimulus [ lipopolysaccharide (LPS) + interferon gamma (IFNgamma) ] and on vascular permeability in air pouches of mice injected with LPS + IFNgamma . Positive_regulation JUN EPHB2 19627209 2112771 Moreover , inhibition of phosphorylated , JNK , and p38 by K. pandurata extract *resulted* in decreased c-Fos expression and [c-Jun] phosphorylation induced by UV light . Positive_regulation JUN EPHB2 19798549 2195757 Further , inhibitor *inhibited* significantly OPN expression , Elk1 phosphorylation , and [activator protein-1 (AP-1)-DNA] binding activation , but not FAK phosphorylation , in the force applied cells . Positive_regulation JUN EPHB2 19935718 2210117 In addition , OHT induced *dependent* expression of c-Fos and transactivation of an [AP-1-responsive] promoter . Positive_regulation JUN EPHB2 20331627 2299866 Moreover , c-Fos and [c-Jun] , the major downstream components of MAPKs , were *up-regulated* by and JNK , respectively . Positive_regulation JUN EPHB2 20458747 2307552 Activation of extracellular signal regulated kinase ( ERK ) and [c-Jun-N-terminal kinase (JNK)] by TPA was identified , and TPA induced migration and MMP-9 activity was significantly *blocked* by inhibitor PD98059 and U0126 , but not JNK inhibitor SP600125 . Positive_regulation JUN EPHB2 20693392 2322964 Finally , the IL-18 induction of MMP-9 was mediated in part via EMMPRIN and through JNK- and *dependent* [AP-1] activation and p38 MAPK dependent NF-?B activation . Positive_regulation JUN EPHB2 21047770 2349295 CADPE inhibits PMA stimulated gastric carcinoma cell invasion and matrix metalloproteinase-9 expression by *mediated* [AP-1] activation . Positive_regulation JUN EPHB2 21311105 2388662 To clarify the signal transduction pathways related to the regulation of the viral genes by alloferon , we confirmed that the calcium influx into BCBL-1 was apparently inhibited by alloferon , which preceded the suppression of the phosphorylation of and the *activation* of [AP-1] by TPA . Positive_regulation JUN EPHB2 21317295 2410672 The results showed that formation of reactive oxygen species and subsequent *activation* of and P38 , but not [Jun] NH2-terminal kinase , are molecular events underpinning retinal microglial TNF-a release during AGA treatment . Positive_regulation JUN EPHB2 21862593 2490914 The increased expression of [c-JUN] was *dependent* on ATF2 and on activation of the and JNK arms of the MAPK signaling pathways . Positive_regulation JUN EPHB2 22411631 2630617 The specific mitogen activated protein kinase inhibitor , U0126 , *blocks* N. fowleri mediated [AP-1] activation and subsequent IL-8 induction . Positive_regulation JUN EPHB2 22644739 2675873 Gastric mucosal cell proliferation induced by exposure to high transmural pressure may be related to early activation of , the induction of c-fos and c-myc , and the *activation* of [AP-1] . Positive_regulation JUN EPHB2 23166329 2723316 only the inhibition of significantly *suppressed* the [AP-1] activity . Positive_regulation JUN EPHB2 23274856 2758060 CTGF mediated increase of NF-?B and [AP-1] luciferase activity was *inhibited* by FAK , MEK , and inhibitors or mutants . Positive_regulation JUN EPHB2 23490067 2766607 Furthermore , activation of extracellular regulated kinase (ERK) and [c-Jun N-terminal kinase (JNK)] by TPA+AA was identified in HL-60 cells , and the inhibitor , PD98059 , but not the JNK inhibitor , SP600125 , *inhibited* TPA+AA induced NBT positive cells . Positive_regulation JUN EPHB2 24220687 2892199 Subsequent studies revealed that sanguinarine suppressed TPA induced NF-?B and [AP-1] *activation* , as well as the phosphorylation of Akt and . Positive_regulation JUN EPHB2 24239652 2897704 Specifically , HA-induced NF-?B activation was mediated by ROS and AKT , and that HA-induced [AP-1] activation was *mediated* by JNK and . Positive_regulation JUN EPHB2 24447911 2923051 Ang II induced miR-21 expression in primary mouse cardiac fibroblasts ( CFs ) via *dependent* [AP-1] and STAT3 activation , and while a miR-21 inhibitor reversed Ang II-induced RECK suppression , a miR-21 mimic inhibited both RECK expression and Ang II-induced CF migration . Positive_regulation JUN EPHB2 8642312 362947 Our results suggest that defects in both JNK and may *result* in the decreased [AP-1] activity and the reduced IL-2 transcription observed in anergic T cells . Positive_regulation JUN EPHB2 9573527 502459 These results indicate that ANP is able to *inhibit* ET-1 induced activation of [AP-1] by inhibiting both and JNK , suggesting that ANP might be able to counteract the expression of AP-1 dependent genes induced by ET-1 . Positive_regulation JUN EPHB2 9591768 505378 JNK and activations were *followed* by a 3.9-fold increase in arterial [AP-1] DNA binding activity , which contained c-Jun and c-Fos proteins . Positive_regulation JUN EPHB2 9687508 522243 Consistently , MEK induced activation in PC12 cells *induces* [c-Jun] expression , while JNK signalling does not . Positive_regulation JUN FAS 10070035 594258 Signaling through *results* in activation of JNK and [AP-1] binding activity that is increased in the presence of IFN-gamma . Positive_regulation JUN FAS 10391681 626725 ligation in the presence of cycloheximide *induced* [Jun N-terminal kinase 1 (JNK1)] and JNK2 phosphorylation , caspase activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation JUN FAS 10602493 574842 *Activation* of [c-Jun N-terminal kinase (JNK)] by ligation is caspase dependent , suggesting that caspases may regulate activators of the JNK pathway . Positive_regulation JUN FAS 11400169 824377 Cross linking of CD95 enhanced [AP-1] DNA binding activity and AP-1 dependent *transactivation* , which were both significantly reduced by different NO-donors compounds . Positive_regulation JUN FAS 11483955 844631 Here we have used a screen for proteins that interact physically with the cytoplasmic domain of the type II TGF-beta receptor to isolate the gene encoding Daxx - a protein associated with the Fas receptor that mediates activation of [Jun amino-terminal kinase (JNK)] and programmed cell death *induced* by . Positive_regulation JUN FAS 11689460 876268 CD40 activation induced , *dependent* apoptosis and [NF-kappaB/AP-1] signaling in human intrahepatic biliary epithelial cells . Positive_regulation JUN FAS 12556535 1071634 Apoptosis signal regulating kinase 1 ( ASK1 ) is a MAP kinase kinase kinase ( MAPKKK ) that is required for [c-Jun N-terminal kinase (JNK)] and p38 activation in *response* to and tumor necrosis factor (TNF) receptor stimulation , and for oxidative stress- and TNFalpha induced apoptosis . Positive_regulation JUN FAS 12681512 1077497 AP20187 mediated dimerization *induced* not only apoptosis but also [Jun N-terminal kinase (JNK)] activation . Positive_regulation JUN FAS 16646028 1557228 stimulation *activated* NF-kappaB and [AP-1] , and this response required caspase activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation JUN FAS 17208988 1732443 Ten days post-MI , apoptosis among granulation tissue cells was significantly suppressed in the olmesartan treated hearts , where expression of , Bax , procaspase-3 , and Daxx and *activation* of caspase-3 , c-Jun NH ( 2 ) -terminal kinase , and [c-Jun] were all significantly attenuated . Positive_regulation JUN FAS 21257927 2469708 activation *resulted* in phosphorylation of the mitogen activated kinases extracellular signal regulated kinase ( ERK ) and [c-Jun-N-terminal kinase (JNK)] , and pharmacologic inhibition of ERK and JNK attenuated KC release in a dose-response manner . Positive_regulation JUN FAS 8562955 349057 ligation *induces* apoptosis and [Jun] kinase activation independently of CD45 and Lck in human T cells . Positive_regulation JUN FAS 8562955 349059 Further , in normal and CD45- or Lck-deficient cell lines , stimulation *results* in activation of [Jun kinase (JNK)] , a proposed mediator of stress activation pathways . Positive_regulation JUN FAS 8647190 363436 Rather , ligation strongly *activates* [Jun kinase (JNK)] . Positive_regulation JUN GRIK2 19449206 2136072 As result , the inhibition of JNK activation caused by *diminishes* the phosphorylation of the transcription factor [c-Jun] , down-regulates FasL expression and attenuates bax translocation , release of cytochrome c and the activation of caspase-3 . Positive_regulation JUN IL1B 10564178 567159 However , Dex did not inhibit *induced* nuclear translocation of nuclear factor-kappaB or [activator protein-1] in HASM cells . Positive_regulation JUN IL1B 10640438 577520 The transcription factors , c-Jun and ATF2 , are phosphorylated by the MAPKs and are implicated in the upregulation of c-Jun . and TNF alpha *stimulated* the phosphorylation of [c-Jun] and ATF2 . Positive_regulation JUN IL1B 10640438 577523 However , *induced* a greater increase in [c-Jun] protein . Positive_regulation JUN IL1B 10640438 577524 Inhibitors of protein kinase C ( PKC ) ( Ro318220 , GF109203X ) and the ERK cascade ( PD98059 ) attenuated the increase in [c-Jun] *induced* by , but LY294002 ( an inhibitor of phosphatidylinositol 3' kinase ) and SB203580 ( an inhibitor of p38-MAPK , which also inhibits certain JNK isoforms ) had no effect . Positive_regulation JUN IL1B 10640438 577525 These data illustrate that some of the pathological effects of IL-1 beta and TNF alpha may be mediated through the MAPK cascades , and that the ERK cascade , rather than JNKs or p38-MAPKs , are implicated in the *upregulation* of [c-Jun] by . Positive_regulation JUN IL1B 10807411 692193 To investigate whether *activates* MAP kinases [ extracellular signal regulated kinases ( ERKs ) , [c-Jun NH2-terminal kinases (JNKs)] and p38 MAP kinase (p38 MAPK) ] and nuclear factor (NF)-kappaB . Positive_regulation JUN IL1B 10884313 709541 However , pretreatment with oATP downregulated *activation* of NF-kappaB and [AP-1] by or TNFalpha . Positive_regulation JUN IL1B 11028561 739589 Geldanamycin , which has been shown in studies to inhibit AP-1 activation , blocked induced [AP-1] luciferase gene *activation* and IL-6 production . Positive_regulation JUN IL1B 11052811 743467 The *stimulated* the collagenase-CAT and [AP-1-CAT] activities in a dose dependent manner with respect to the amount of DNA used in transfections . Positive_regulation JUN IL1B 11404398 825492 Using reporter constructs and electromobility shift assays , we found that cotreatment of astrocyte cultures with ATP ( 1-100 microm ) significantly potentiated mediated *activation* of NF-kappaB and [AP-1] and that ATP alone activated AP-1 . Positive_regulation JUN IL1B 11557268 861285 *induced* [Jun N-terminal kinase (JNK)] activation was also suppressed selectively by tranilast . Positive_regulation JUN IL1B 11739520 886553 regulation of glucose transport in chondrocytes depends on protein kinase C and p38 signal transduction pathways , and does not *require* phosphoinositide 3-kinase , extracellular signal related kinase , or [c-Jun] N-terminal kinase activation . Positive_regulation JUN IL1B 12028436 947485 rapidly *activated* extracellular signal regulated kinase ( ERK ) and [c-Jun NH2-terminal kinase (JNK)] , which were involved in the up-regulation of COX-2 induction , but 15d-PGJ2 inhibited the activation of these kinases . Positive_regulation JUN IL1B 12064845 953435 Of note , in OA chondrocytes , IL-17 and *induced* collagenase-3 production through [AP-1] occurred with differential protein complexes : IL-17 stimulation resulted in FosB activation , while IL-1beta stimulated c-Fos . Positive_regulation JUN IL1B 12064845 953442 We demonstrated that IL-17 and *induced* collagenase-3 production in OA chondrocytes mainly through [AP-1] mediated transcriptional activity but with differential protein complexes , suggesting that some AP-1 proteins play a pivotal role in the different cytokine responses in terms of collagenase-3 production . Positive_regulation JUN IL1B 12126643 966027 Electrophoretic mobility shift assays confirmed that *increased* [AP-1] and NF-kappaB DNA binding activities in a time dependent manner . Positive_regulation JUN IL1B 12131776 966843 and TNF-alpha *increased* the nuclear factor-kappa B (NF-kappa B)-specific and [activator protein-1-specific] DNA binding activity , whereas the NF-IL6 activity was not altered . Positive_regulation JUN IL1B 12498315 1026315 *activated* nuclear factor-kappaB , [activator protein-1] , and three classes of mitogen activated protein ( MAP ) kinases : extracellular signal regulated kinase1/2 , c-Jun N-terminal kinase , and p38 MAP kinase . Positive_regulation JUN IL1B 12507586 1038430 We discovered that EGCG inhibited the *induced* phosphorylation of c-Jun N-terminal kinase (JNK) isoforms , accumulation of [phospho-c-Jun] and DNA binding activity of AP-1 in osteoarthritis ( OA ) chondrocytes . Positive_regulation JUN IL1B 12594282 1060897 BMP-7 inhibited *induced* [AP-1] activity in a concentration dependent manner . Positive_regulation JUN IL1B 12760902 1119662 The EMSAs demonstrated that both and TGF-beta1 *induced* [AP-1] activation within 2 h after stimulation , and a blockade of AP-1 activation by the recombinant adenovirus containing a dominant negative c-Jun markedly reduced the IL-1beta- and TGF-beta1 induced IL-11 mRNA expression . Positive_regulation JUN IL1B 14527176 1148350 Rhein inhibits *induced* activation of MEK/ERK pathway and DNA binding of NF-kappa B and [AP-1] in chondrocytes cultured in hypoxia : a potential mechanism for its disease modifying effect in osteoarthritis . Positive_regulation JUN IL1B 14669327 1178233 *activated* nuclear factor-kappaB , [activator protein-1] , and MAP kinases . Positive_regulation JUN IL1B 14686613 1179400 Hydrogen peroxide mediates *induced* [AP-1] activation in articular chondrocytes : implications for the regulation of iNOS expression . Positive_regulation JUN IL1B 15056867 1230151 It was found that overexpression of Tom1 suppresses activation of transcription factors , NF-kappaB and [AP-1] , *induced* by either or tumor necrosis factor (TNF)-alpha and that the VHS domain of Tom1 is indispensable for its suppressive activity . Positive_regulation JUN IL1B 15059969 1251496 The effect of NSMase-2 expression on *induced* activation of [c-Jun N-terminal kinase (JNK)] was tested . Positive_regulation JUN IL1B 15145599 1247717 Lipopolysaccharide (LPS) has a negative impact on long-term potentiation ( LTP ) in the rat hippocampus , which has been correlated with increased concentration of and *activation* of p38 and [c-Jun N-terminal kinase (JNK)] . Positive_regulation JUN IL1B 15161854 1252955 Blockade of PI3K/Akt abolished *induced* nuclear translocation of [AP-1] , whereas the induction of IkappaB degradation was unchanged . Positive_regulation JUN IL1B 15208668 1281356 Electrophoretic mobility shift assay confirmed that *increased* the DNA binding activity of [AP-1] and NF-kappaB . Positive_regulation JUN IL1B 15326113 1287293 Dexamethasone also inhibited the *induced* phosphorylation of the MAPKs extracellular signal regulated kinase ( ERK ) and [c-Jun N-terminal kinase (JNK)] , but not that of p38 . Positive_regulation JUN IL1B 15341531 1291756 In accordance with these findings , *stimulated* phosphorylation of p42/p44 MAPK , p38 , and [c-Jun N-terminal kinase (JNK)] , which was attenuated by U0126 , SB202190 , or SP600125 , respectively . Positive_regulation JUN IL1B 15529381 1335747 *induced* DNA binding of NF-kappaB and [AP-1] was significantly higher in hypoxic and reoxygenated cultures than in normoxia . Positive_regulation JUN IL1B 15615726 1375501 The evidence indicates that IL-4 modulates expression of IL-1beta mRNA and protein and that it attenuates *induced* impairment of LTP and phosphorylation of JNK and [c-Jun] . Positive_regulation JUN IL1B 15677771 1395416 In fibroblasts from control subjects , *increased* c-Jun expression , [c-Jun] activation , and KGF secretion . Positive_regulation JUN IL1B 15677771 1395417 By contrast , in IPF fibroblasts , did not *increase* c-Jun expression and [c-Jun] activation , and weakly increased KGF secretion , whereas SP600125 had no effect . Positive_regulation JUN IL1B 15683721 1370662 Although and IFN-gamma alone *induced* the activation of [AP-1] , the combination of these two cytokines ( IL-IF ) markedly inhibited the activation of AP-1 . Positive_regulation JUN IL1B 15683721 1370665 Consistently , JNK-I , a specific inhibitor of JNK , inhibited *mediated* activation of [AP-1] and expression of iNOS . Positive_regulation JUN IL1B 15860218 1400800 FK506 also prevented *stimulated* JNK activation and transcriptional activation of [AP-1] in these cells . Positive_regulation JUN IL1B 15908470 1451831 In addition , EtOH significantly reduced NF-kappaB and [AP-1] binding activity *induced* by and inhibited MCP-1 gene transcription . Positive_regulation JUN IL1B 15961395 1440753 *induced* expression and transient phosphorylation of [c-Jun] in primary cultured chondrocytes . Positive_regulation JUN IL1B 15961395 1440758 Consistent with its ability to induce phosphorylation of c-Jun , *caused* transient activation of [AP-1] , which is necessary for IL-1beta induced dedifferentiation . Positive_regulation JUN IL1B 16269458 1509291 On the other hand , TNFalpha and *induced* p38 , [c-Jun N-terminal kinase (JNK)] , and nuclear factor (NF)kappaB activation , pathways more closely related to stress response . Positive_regulation JUN IL1B 16359550 1494032 IL-1beta induced MMP-12 activity and gene expression was down-regulated by the corticosteroid dexamethasone but up-regulated by the inflammatory cytokine tumour necrosis factor (TNF)-alpha through enhancing [activator protein-1] *activation* by . Positive_regulation JUN IL1B 16528573 1549409 *activates* beta cell [c-Jun N-terminal kinase (JNK)] , extracellular signal regulated kinase ( ERK ) and p38 , all of which are members of the mitogen activated protein kinase (MAPK) family . Positive_regulation JUN IL1B 16569740 1568493 OTR promoter contains putative transcription factor binding sites for [activating protein-1 (AP-1)] , CCAAT/enhancer binding protein (C/EBP) , and nuclear factor-kappaB (NF-kappaB) , which may be *activated* by , whose concentrations increase with labor . Positive_regulation JUN IL1B 16729332 1565833 In conclusion , and CDCA inhibit HNF4 alpha but *induce* [c-Jun] , which in turn blocks HNF 4 alpha recruitment of PGC-1 alpha to the CYP7A1 chromatin and results in inhibition of CYP7A1 gene transcription . Positive_regulation JUN IL1B 16802349 1599715 *induced* [AP-1] binding activity and AP-1-driven gene expression were strictly MKK-7 dependent . Positive_regulation JUN IL1B 16912429 1602075 Inhibition of *induced* activation of MEK/ERK pathway and DNA binding of NF-kappaB and [AP-1] : potential mechanism for Diacerein effects in osteoarthritis . Positive_regulation JUN IL1B 17191021 1688464 While resveratrol had no effect on MCP-1 mRNA degradation , it inhibited MCP-1 promoter activity and reduced nuclear factor kappaB and [activator protein-1] binding activity *induced* by . Positive_regulation JUN IL1B 17218407 1709702 In contrast , *increased* both [AP-1] and NF-kappaB DNA binding at 1 h only . Positive_regulation JUN IL1B 17390080 1716124 We have previously demonstrated that *induced* HBD-2 mRNA expression in A549 cells through activation of nuclear factor-kappaB (NF-kappaB) transcriptional factor as well as p38 mitogen activated protein kinase (MAPK) , [c-Jun N-terminal kinase (JNK)] , or phosphatidylinositol-3-kinase (PI3K) . Positive_regulation JUN IL1B 17481780 1750510 In the present study , we found that stimulation *induced* [c-Jun N-terminal kinase (JNK)] activity within 15min in A549 cells . Positive_regulation JUN IL1B 17481780 1750513 In investigating whether JNK was involved in IL-1beta induced CGRP secretion , the JNK II inhibitor SP600125 was used and it significantly attenuated *induced* CGRP secretion and [c-Jun] activity , which was elevated after IL-1beta stimulation from mRNA to protein level . Positive_regulation JUN IL1B 17888210 1797464 The drug reduced *induced* NF-kappaB and [AP-1] DNA binding , as well as the phosphorylation of ERK and JNK . Positive_regulation JUN IL1B 17983423 1850439 Chondroitin sulfate reduced *induced* NF-kappaB nuclear translocation , but not [AP-1] translocation , it decreased IL-1beta induced phosphorylation of Erk1/2 and abrogated p38MAPK phosphorylation , but did not prevent IL-1beta induced increase in nitrite . Positive_regulation JUN IL1B 18337234 1898215 Since *activates* NFkappaB , [AP-1] and C/EBP , we over expressed these transcription factors alone and in combination and found that only NFkappaB alone increased FP mRNA expression . Positive_regulation JUN IL1B 18340449 1932042 A slightly synergistic effect on the activation of [AP-1] *induced* by was shown in the presence of GLN . Positive_regulation JUN IL1B 18467203 1921434 EMSA showed that and TNF-alpha *activated* NF-kappaB and [AP-1] in MG-63 cells . Positive_regulation JUN IL1B 18599158 2208602 and ( 3 ) S100B/RAGE induced upregulation of COX-2 , and TNF-alpha expression *requires* the concurrent activation of NF-kappaB and [AP-1] . Positive_regulation JUN IL1B 19056796 2017701 Moreover , cordycepin significantly inhibited *induced* p38/JNK and [AP-1] activation , but not extracellular signal regulated kinase ( ERK ) and NF-kappaB activation . Positive_regulation JUN IL1B 19228941 2044728 Increasing evidence demonstrates that interleukin (IL)-32 is a pro-inflammatory cytokine , *inducing* IL-1alpha , , IL-6 , tumor necrosis factor (TNF)-alpha , and chemokines via nuclear factor (NF)-kappaB , p38 mitogen activated protein kinase (MAPK) , and [activating protein (AP)-1] activation . Positive_regulation JUN IL1B 19544469 2128851 Surprisingly , did not *activate* the NF-kappaB pathway or the transcription factor [activating protein 1 (AP-1)] , but inhibition of nuclear translocation of NF-kappaB by SN50 facilitated IL-1beta induced Nurr1 expression and dopaminergic differentiation of mdNPCs . Positive_regulation JUN IL1B 19616091 2124143 In addition , the *induced* [c-Jun] phosphorylation was reduced by pretreatment with U0126 or SP600125 . Positive_regulation JUN IL1B 19836480 2203150 Curcumin blocks *induced* proteoglycan degradation , [AP-1/NF-kappaB] signalling , chondrocyte apoptosis and activation of caspase-3 . Positive_regulation JUN IL1B 19839866 2155212 Under high glucose conditions , significantly *increased* expression of [c-Jun] and decreased the expression of glutamine synthetase . Positive_regulation JUN IL1B 20038579 2205271 Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and induced IKK/NF-kappaB and [JNK/AP-1] *activation* . Positive_regulation JUN IL1B 20432452 2268152 *stimulated* [AP-1] activation was blocked by U0126 or SP600125 , revealing that ERK and JNK linked to AP-1 on these responses . Positive_regulation JUN IL1B 20600535 2316083 Moreover , *induced* [activator protein-1 (AP-1)] and nuclear factor-kappaB (NF-kappaB) activation were inhibited by luteolin . Positive_regulation JUN IL1B 7950978 277367 These cells also possess bradykinin B2 receptors coupled to phospholipase C and consequent increases in intracellular calcium and protein kinase C . *causes* an increase in c-fos , [AP-1] transcriptional activity and an increased expression of several genes including NGF , but the initial signalling events are unknown . Positive_regulation JUN IL1B 8430810 212757 In addition , IL-6 , tumor necrosis factor-alpha , and , cytokine regulators of the acute phase response , *stimulated* expression of an [AP-1] responsive reporter gene introduced by DNA mediated transfection into adult rat hepatocytes in primary culture . Positive_regulation JUN IL1B 8627304 355870 Activation of the transcription factor nuclear factor-kappa B by IL-1 beta involved ROIs , whereas the *induced* activation of the [transcription factor AP-1] was mediated via protein kinase C . Positive_regulation JUN IL1B 9573527 502457 Finally , ANP was able to inhibit ET-1- , but not *induced* increase in DNA binding activity of [AP-1] by gel shift assay . Positive_regulation JUN IL1R2 10383449 624592 Because it has been shown that members of the TRAF family are involved in *activation* of NF-kappaB and the [c-Jun N-terminal kinase (JNK)] by the and members of the TNF receptor superfamily , a role of TRAF1 in receptor cross-talk and/or feedback regulation of activated receptor signaling complexes can be suggested . Positive_regulation JUN MAP2K6 10484455 644118 Elk-1 and [activator protein-1] reporter activation by mitogens was similarly *inhibited* by inhibition of , suggesting a linkage between p42/p44 activation , transcription factor activation , and HASM proliferation . Positive_regulation JUN MAP2K6 11267996 797293 Extracellular signal regulated kinases ( ERK1 and ERK2 ) are also involved as the inhibitor , PD98059 , *reduced* both ATP evoked ( 3 ) H-thymidine incorporation and c-Fos and [c-Jun] expression . Positive_regulation JUN MAP2K6 11408617 826076 Interestingly , resveratrol had little effect on the *induction* of [AP-1] reporter gene by active Raf-1 , MEKK1 , or , suggesting that it inhibited MAPK pathways by targeting the signaling molecules upstream of Raf-1 or MEKK1 . Positive_regulation JUN MAP2K6 11716547 881766 Both point mutations in this motif and the expression of a c-jun protein lacking its transactivation domain and therefore acting as a dominant negative [AP-1] mutant abrogated *dependent* promoter stimulation . Positive_regulation JUN MAP2K6 12057768 952187 The inhibitor , PD98059 , partially *blocked* the C5a mediated increase in [AP-1] binding . Positive_regulation JUN MAP2K6 12648218 1070360 The 1alpha,25-dihydroxyvitamin D3-induced [activator protein 1] DNA binding activity was completely *blocked* by the inhibitor PD 98059 indicating that the MEK/extracellular signal regulated kinase pathway is involved in the activation of activator protein 1 . Positive_regulation JUN MAP2K6 15005710 1217483 In contrast , concomitant stimulation of the STAT3 signal and a markedly *increased* [AP-1] activity with enhanced c-Fos expression . Positive_regulation JUN MAP2K6 15238218 1269805 Induction of COX-2 and [c-Jun] by EGF was completely *suppressed* by inhibitor combined with JNK inhibitor . Positive_regulation JUN MAP2K6 15844632 1353017 The effects on transglutaminase-1 and [AP-1] were *dependent* on protein kinase C and . Positive_regulation JUN MAP2K6 16442502 1521650 7 ( MKK7 ) is a direct *activator* of the mitogen activated protein kinase family member [c-Jun N-terminal kinase (JNK)] . Positive_regulation JUN MAP2K6 17079470 1642909 DNA binding and transcriptional activities of [AP-1] were *increased* by or H-Ras as evidenced by electrophoretic mobility shift assay and luciferase assay using an AP-1-driven plasmid . Positive_regulation JUN MAP2K6 17537724 1767281 The reduction in caerulein induced pancreatic inflammation is dependent upon Tpl2 ablation in non-myeloid cells and is associated with both in vivo and in vitro inhibition of , JNK , and [AP-1] *activation* and the expression of MCP-1 , MIP-2 , and interleukin-6 . Positive_regulation JUN MAP2K6 19190345 2039008 signaling *induces* [JUN/activator] protein 1 activation , which is essential for oncogenic transformation , in combination with the GLI activator forms GLI1 and GLI2 . Positive_regulation JUN MAP2K6 21047770 2349301 CADPE inhibits PMA stimulated gastric carcinoma cell invasion and matrix metalloproteinase-9 expression by mediated [AP-1] *activation* . Positive_regulation JUN MAP2K6 21278800 2398230 Here , we show that RASSF7 interacts with N-Ras and 7 ( MKK7 ) to negatively *regulate* [c-Jun N-terminal kinase (JNK)] signaling . Positive_regulation JUN MAP2K6 21862593 2490920 The increased expression of [c-JUN] was *dependent* on ATF2 and on activation of the and JNK arms of the MAPK signaling pathways . Positive_regulation JUN MAP2K6 22411631 2630624 The specific inhibitor , U0126 , *blocks* N. fowleri mediated [AP-1] activation and subsequent IL-8 induction . Positive_regulation JUN MAP2K6 8637721 362421 The over-expression of MUK or in NIH3T3 or COS1 cells *results* in the activation of JNK1 and the accumulation of a hyper phosphorylated form of [c-Jun] . Positive_regulation JUN MAP2K6 9687508 522249 Consistently , induced ERK activation in PC12 cells *induces* [c-Jun] expression , while JNK signalling does not . Positive_regulation JUN MAP2K6 9858557 582169 In cells expressing a conditionally active form of Raf-1 ( DeltaRaf-1 : ER ) , we observed that selective , sustained activation of was sufficient to induce expression of Fra-1 , Fra-2 , and JunB but , interestingly , *induced* little or no c-Fos or [c-Jun] . Positive_regulation JUN MUC16 15262961 1290129 Tobacco smoke control of production in lung cells *requires* oxygen radicals [AP-1] and JNK . Positive_regulation JUN NEDD9 10866674 706091 Finally , the induction of expression also *increases* [Jun N-terminal protein kinase (JNK)] activation , and activated JNK colocalizes with HEF1 , implicating this pathway in HEF1 action . Positive_regulation JUN PLAU 15558021 1361106 Both FGF-2 and phorbol ester-inducible ( uPA ) expression *requires* [AP-1] binding to an enhancer element in the uPA promoter , and we have previously shown that FGF-2 or PMA induction of uPA expression is strongly dependent on MEKK1 . Positive_regulation JUN PLAU 9037208 415309 Since transcription factors bound to AP-1 recognition sequences within the PAI-2 gene promoter play a role in basal and phorbol ester mediated induction of PAI-2 gene expression , we hypothesised that *mediated* modulation of [AP-1] activity would in turn influence constitutive and inducible PAI-2 gene expression . Positive_regulation JUN RARB 12123542 965450 is *required* for [anti-activator protein-1] activity by retinoic acid in gastric cancer cells . Positive_regulation JUN RARB 12123542 965452 might be *required* for [anti-AP-1] activity , and contribute to growth inhibition of gastric cancer cells by ATRA . Positive_regulation JUN RARB 15308638 1322574 Because AP-1 activity was not irreversibly disturbed , but could be switched on through activation of the Jun N-terminal kinase pathway , a model for the transient activation of [AP-1] even in the *presence* of as repressor is suggested . Positive_regulation JUN S100A7 18194266 1918940 Furthermore , *induces* phosphorylation of mitogen activated protein kinase p38 and extracellular signal regulated kinase ( ERK ) , but not [c-Jun N-terminal kinase (JNK)] , both of which are required for the production of cytokines and chemokines as evidenced by the inhibitory effects of p38 and ERK inhibitors on psoriasin mediated neutrophil activation . Positive_regulation JUN S100B 18599158 2208600 and ( 3 ) induced upregulation of COX-2 , IL-1beta and TNF-alpha expression *requires* the concurrent activation of NF-kappaB and [AP-1] . Positive_regulation JUN SELL 9415029 471872 In the present study we demonstrate that stimulation of Jurkat T lymphocytes via *results* in an activation of [Jun N-terminal kinase (JNK)] but not of p38-K . Positive_regulation JUN SLC38A3 20150185 2214733 Knockdown of endogenous JNK1 expression via small interference RNA ( JNK1-siRNA ) inhibited *induced* phosphorylation of [c-Jun] and migration , and overexpression of wild-type JNK1 or constitutive active JNK1 promoted G17 induced migration . Positive_regulation JUN SPHK1 15485866 1347367 Mechanistically , experiments utilizing TIMP-1 promoter constructs demonstrated that the action of SphK1 on the TIMP-1 promoter is through the AP1-response element , consistent with the *mediated* up-regulation of [phospho-c-Jun] levels , a key component of AP1 . Positive_regulation JUN SPHK1 8206962 261262 Furthermore , an inhibitor of , DL-threo-dihydrosphingosine , which inhibits sphingosine induced DNA synthesis and the formation of sphingosine 1-phosphate , also *inhibited* sphingosine stimulated [AP-1] DNA binding activity . Positive_regulation JUN TFPI2 15218033 1281878 Overexpression of , but not the PP2A catalytic subunit , *blocked* rapamycin induced phosphorylation of [c-Jun] , and protected cells from rapamycin induced apoptosis . Positive_regulation JUN TGM2 23290789 2764007 Suppression of Tgase-2 or the [c-Jun-N-terminal kinase (JNK)] inhibitor , SP600125 , significantly reduced and over-expression of *increased* the expression of N-cadherin . Positive_regulation JUN TLR7 15998638 1447154 Here , we show that A52R does not inhibit *induced* p38 or [c-Jun amino N-terminal kinase (JNK)] mitogen activating protein ( MAP ) kinase activation . Positive_regulation JUN TLR7 17502339 1772669 IFN-gamma suppression of *induced* activation of [AP-1] and downstream target genes challenges current concepts about the inflammatory role of AP-1 proteins in macrophage activation and is consistent with a role for AP-1 in the generation of noninflammatory osteoclasts . Positive_regulation JUN TLR7 20218969 2243522 The mechanism was related to apoE suppression of *induced* phosphorylation of JNK ( c-Jun N-terminal kinase ) and [c-Jun] . Positive_regulation JUN TLR7 21098092 2357776 Rac1 activation is accompanied by JNK ( c-Jun N-terminal kinase ) and NF-?B activation , culminating in *induced* binding of NF-?B and [AP-1] to the promoters of inflammatory cytokines . Positive_regulation JUN TNF 10075082 594850 Suppression of *activated* nuclear transcription factor-kappaB , [activator protein-1] , c-Jun N-terminal kinase , and apoptosis by beta-lapachone . Positive_regulation JUN TNF 10075082 594851 Beta-lapachone also abolished *induced* activation of [AP-1] , c-Jun N-terminal kinase , and mitogen activated protein kinase kinase ( MAPKK or MEK ) . Positive_regulation JUN TNF 10359524 619080 Conversion of HPV 18 positive non-tumorigenic HeLa-fibroblast hybrids to invasive growth involves loss of *mediated* repression of viral transcription and modification of the [AP-1] transcription complex . Positive_regulation JUN TNF 10439045 635220 In the present report we investigated the effect of gamma-GCS overexpression on the *induced* activation of nuclear transcription factors NF-kappa B and AP-1 , stress activated protein [kinase/c-Jun amino-terminal kinase (JNK)] and apoptosis . Positive_regulation JUN TNF 10439045 635248 gamma-GCS also abolished the activation of [AP-1] *induced* by and inhibited TNF induced activation of JNK and mitogen activated protein kinase kinase . Positive_regulation JUN TNF 10521481 653107 The study presented here shows that autoregulation of gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 mitogen activated protein (MAP) kinase activity and the binding of the transcription factors ATF-2 and [Jun] to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation JUN TNF 10540155 563252 The EMSAs indicated that sodium butyrate suppressed *induced* nuclear factor (NF)-kappaB- and [activation protein (AP)-1-DNA] binding activity , but enhanced TNF-alpha induced activation of CCAAT/enhancer binding protein ( C/EBP)beta (NF-IL-6 ) -DNA binding activity . Positive_regulation JUN TNF 10601128 574188 alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 MAPK , and [c-Jun] N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation JUN TNF 10615065 656332 however , *induced* both [AP-1] and NF-kappaB binding activities in BET-1A cells . Positive_regulation JUN TNF 10615072 656335 We tested the hypothesis that protein kinase ( PK ) G activation in response to nitric oxide ( ( * ) NO ) mediates *induced* activation of the transcription factor [activating protein-1 (AP-1)] in pulmonary microvessel endothelial monolayers ( PEM ) . Positive_regulation JUN TNF 10615072 656336 treatment ( 1,000 U/ml ) for 4 h *induced* a significant increase in DNA binding of [AP-1] . Positive_regulation JUN TNF 10617615 657104 TRAF2 is required for *induced* activation of [c-Jun] N-terminal kinase/stress activated protein kinase ( JNK/SAPK ) , and TRAF2 can also mediate activation of NF-kappaB . Positive_regulation JUN TNF 10640438 577519 The transcription factors , c-Jun and ATF2 , are phosphorylated by the MAPKs and are implicated in the upregulation of c-Jun . IL-1 beta and *stimulated* the phosphorylation of [c-Jun] and ATF2 . Positive_regulation JUN TNF 10754482 682701 The binding activity of [AP-1] was found to be stimulated by the growth inhibitory cytokines , TGF-beta1 and TNF-alpha , and the binding of NF-kappaB was *stimulated* by . Positive_regulation JUN TNF 10764744 698805 TNF-alpha signaling was not altered by the overexpression of catalase , as *activation* of nuclear factor kappaB and [AP-1] by was similar in the three cell lines . Positive_regulation JUN TNF 10788437 688681 [AP-1] activation *induced* by and ceramide was also suppressed by hCG . Positive_regulation JUN TNF 10799874 691387 p56lck was also found to be required for HIV-tat induced but not *induced* [AP-1] activation . Positive_regulation JUN TNF 10815802 693544 The increase in TNF receptors sensitized H596 cells to *induced* activation of NF-kappaB , [AP-1] and apoptosis . Positive_regulation JUN TNF 10815802 693545 A549 cells , however , were completely resistant to *induced* activation of NF-kappaB , [AP-1] and apoptosis . Positive_regulation JUN TNF 10820260 694384 Vesnarinone also blocked NF-kappa B activation induced by several other inflammatory agents , inhibited the *induced* activation of [transcription factor AP-1] , and suppressed the TNF induced activation of c-Jun N-terminal kinase and mitogen activated protein kinase kinase . Positive_regulation JUN TNF 10871845 708295 Besides NF-kappaB , anethole also suppressed *induced* activation of the [transcription factor AP-1] , c-jun N-terminal kinase and MAPK-kinase . Positive_regulation JUN TNF 10884313 709540 However , pretreatment with oATP downregulated *activation* of NF-kappaB and [AP-1] by IL-1beta or . Positive_regulation JUN TNF 10903915 713437 We demonstrated here that intracellular localization of these redox molecules differ from each other and that the redox molecules differentially regulate NF-kappaB , [AP-1] , and CREB activation *induced* by , PMA , and forskolin and by expression of signaling intermediate kinases , NIK , MEKK , and PKA in HEK293 cells . Positive_regulation JUN TNF 10919658 717269 Oleandrin also blocked [AP-1] activation *induced* by and other agents and inhibited the TNF induced activation of c-Jun NH2-terminal kinase . Positive_regulation JUN TNF 10954916 724651 Besides NF-kappaB , the *activation* of [AP-1] by also was blocked by Bcl-x ( L ) . Positive_regulation JUN TNF 10974006 729128 Our results show that glucocorticoids antagonize the *induced* activation of [AP-1] by causing the accumulation of inactive JNK without affecting its subcellular distribution . Positive_regulation JUN TNF 11007940 735629 The promoter regions of the human gamma-GCS subunits contain [AP-1] , NF-kappa B , and antioxidant response elements and are *regulated* by oxidants , growth factors , inflammatory cytokine , and anti-inflammatory agent ( dexamethasone ) in lung cells . Positive_regulation JUN TNF 11007940 735640 also *induces* the activation of NF-kappa B and [AP-1] and the subsequent increase in gamma-GCS heavy subunit transcription in these cells . Positive_regulation JUN TNF 11046018 742740 Because the nuclear transcription factors NF-kappaB and AP-1 have recently been reported to mediate anti-apoptosis and cell survival , we hypothesized that IFN-alpha potentiates the cytotoxic effects of TNF by suppressing *induced* activation of NF-kappaB and [AP-1] . Positive_regulation JUN TNF 11046018 742743 We tested this hypothesis by pretreating human Jurkat T cells with IFN-alpha , which blocked induced *activation* of NF-kappaB and [AP-1] in a time- and dose dependent manner as determined by EMSA . Positive_regulation JUN TNF 11067959 747614 Leflunomide also inhibited *induced* activation of [AP-1] and the c-Jun N-terminal protein kinase activation . Positive_regulation JUN TNF 11083876 810015 Inhibition of TLR2 had no effect on alpha *induced* NF-kappaB or [AP-1] activation , on the DNA binding of the basal transcription factor Oct-1 , or on hydrogen peroxide induced phosphorylation of p38 MAP kinase . Positive_regulation JUN TNF 11085968 750831 Electrophoretic mobility shift assay demonstrated that *enhanced* DNA binding of osteoblast specific factor ( Osf2 ) , [AP1] , and CREB , transcription factors that are important for osteoblastic differentiation . Positive_regulation JUN TNF 11108246 756736 Thus , *induced* [c-Jun] messenger RNA expression requires ERKs activation , whereas p38MAPK inhibition enhances its expression . Positive_regulation JUN TNF 11108246 756776 Finally , although *induces* [c-Jun N-terminal kinase (JNK)] activation , transfection of a dominant negative of either JNK1 or JNK2 had no effect on TNFalpha induced apoptosis . Positive_regulation JUN TNF 11228746 581001 In contrast , none of the radical quenchers had any significant effect on *induced* [AP-1] activation . Positive_regulation JUN TNF 11228746 581015 Overall , these results suggest that hydroxyl radicals mediate *induced* apoptosis but not activation of NF-kappa B , [AP-1] , and JNK ; Positive_regulation JUN TNF 11298454 803094 The interaction of Nef with ASK1 inhibits both Fas- and mediated apoptosis , as well as the *activation* of the downstream [c-Jun] amino-terminal kinase . Positive_regulation JUN TNF 11466617 840722 The [c-Jun N-terminal kinases (JNK)] have been shown to participate in death signaling triggered by certain stimuli and are *activated* by . Positive_regulation JUN TNF 11672426 872377 KYM-1 human rhabdomyosarcoma cells and HeLa human cervical epithelial cells , engineered to overexpress TNFR2 , displayed [c-Jun N-terminal kinase (JNK)] *activation* by wild-type TNF , a TNFR1-specific TNF mutant and a TNFR2-specific mutant in combination with an agonistic TNFR2-specific monoclonal antiserum . Positive_regulation JUN TNF 11750919 898167 Biochemical and immunocytochemical analysis showed that *activated* p38 mitogen activated protein kinase ( p38MAPK ) and [c-Jun N-terminal kinase (JNK)] but not p42/p44 MAPK . Positive_regulation JUN TNF 11753501 890123 Among these we identified two oncogene products ( [Jun] and Fos ) which were *activated* by or phorbol esters and which promoted the synthesis of MMP-9 . Positive_regulation JUN TNF 11753638 890161 *induced* NF-kappaB activation but not [AP-1] activation in LNCaP cells . Positive_regulation JUN TNF 11880365 937207 also *induced* a transient activation of [c-Jun N-terminal kinase (JNK)] , which upon addition of CDDO was converted to a sustained activation . Positive_regulation JUN TNF 11907583 923597 TRAF2 is required for *mediated* activation of [c-Jun N-terminal kinase (JNK)] , contributes to activation of NF-kappaB , and mediates anti-apoptotic signals , . Positive_regulation JUN TNF 11958820 931303 IGF-2 inhibits *induced* [c-Jun kinase (JNK)] activation of the CG4 cell line . Positive_regulation JUN TNF 12003776 939875 Enalapril protects mice from pulmonary hypertension by inhibiting mediated *activation* of NF-kappaB and [AP-1] . Positive_regulation JUN TNF 12048203 968537 The activation of AKT2 inhibits UV- and *induced* [c-Jun N-terminal kinase (JNK)] and p38 activities that have been shown to be required for stress- and TNF alpha induced programmed cell death . Positive_regulation JUN TNF 12058867 952623 The present study suggests a regulatory interference by 1alpha25 ( OH ) 2D3 for RA inhibition of *induced* [AP-1] activity in osteoblasts . Positive_regulation JUN TNF 12065326 954366 Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells : role of Gab1 and MEKK3 in *induced* [c-Jun] and NF-kappaB activation and adhesion molecule expression . Positive_regulation JUN TNF 12065326 954393 Gab1 associated with MEKK3 , and a catalytically inactive form of MEKK3 inhibited *induced* [c-Jun] and NF-kappaB transcriptional activation , suggesting a critical role for Gab1 and MEKK3 in TNF-alpha signaling . Positive_regulation JUN TNF 12131776 966842 IL-1 beta and *increased* the nuclear factor-kappa B (NF-kappa B)-specific and [activator protein-1-specific] DNA binding activity , whereas the NF-IL6 activity was not altered . Positive_regulation JUN TNF 12162440 971989 Oxidative stress and *induce* histone acetylation and [NF-kappaB/AP-1] activation in alveolar epithelial cells : potential mechanism in gene transcription in lung inflammation . Positive_regulation JUN TNF 12162440 971998 H2O2 , and , and TSA all *increased* NF-kappaB and [AP-1] DNA binding to their consensus sites assessed by the electrophoretic mobility shift assay . Positive_regulation JUN TNF 12168567 973643 or endotoxin *induce* the activation of two major transcription factors , NF-kappa B ( nuclear factor-kappaB ) and [AP-1] ( activating protein-1 ) , which in turn induce genes involved in chronic and acute inflammatory responses . Positive_regulation JUN TNF 12206715 1018750 EGCG as well as VP16 and *induced* activation of two apoptosis regulating mitogen activated protein ( MAP ) kinases , namely [c-Jun N-terminal kinase (JNK)] and p38 MAP kinase , in both human leukaemic U937 and OCI-AML1a cells . Positive_regulation JUN TNF 12297293 991239 *increased* extracellular regulated kinase and [Jun-N-terminal] kinase phosphorylation , but these effects were not related to its inhibitory effect on alpha1 ( I ) procollagen ( col1a1 ) mRNA levels . Positive_regulation JUN TNF 12361763 995019 alone can *induce* MCMV IE-1 gene expression and activation of NFkappaB and [AP-1] in some tissues . Positive_regulation JUN TNF 12473383 1032605 Modulation by caspases of *stimulated* [c-Jun] N-terminal kinase activation but not nuclear factor-kappaB signaling . Positive_regulation JUN TNF 12573143 1029607 Additionally , *induced* activation of NF-kappaB and [AP-1] observed in ML-1a was greatly reduced in clone 19 . Positive_regulation JUN TNF 12573143 1029610 These results indicate that mitochondrial respiratory function regulates induced and constitutive *activation* of NF-kappaB and [AP-1] . Positive_regulation JUN TNF 12631113 1067608 In contrast , curcumin , an [activating protein (AP)-1] inhibitor , attenuated *stimulated* phospho-c-Jun levels and fractalkine expression without discernible effects on TNF-alpha induced degradation of I-kappaBalpha or NF-kappaB nuclear translocation . Positive_regulation JUN TNF 12631113 1067611 Additional experiments examining the role of cAMP on MC fractalkine expression showed that the incubation of MCs with TNF-alpha and either db-cAMP or forskolin attenuated TNF-alpha stimulated fractalkine mRNA and protein expression , preceded by attenuation of *activated* phosphorylation of p42/44 MAPK , and [c-Jun] , but not phosphorylation of PKCzeta/iota or nuclear translocation of NF-kappaB . Positive_regulation JUN TNF 12697682 1081354 *stimulated* the phosphorylation of [c-Jun] and specific inhibition of the Jun N-terminal kinase pathway , but not other MAPK pathways , completely prevented the TNF alpha induced drop in IGF-I mRNA . Positive_regulation JUN TNF 12748169 1113006 Similarly , induced *activation* of [activator protein 1] or NF-IL-6 was not impaired in FAK-/- cells . Positive_regulation JUN TNF 12748303 1089045 TNF induced activation of NF-kappaB is accelerated in SODD-deficient cells , but *induced* [c-Jun] N-terminal kinase activity is slightly repressed . Positive_regulation JUN TNF 12768019 1094507 The reduction appeared to be due to relocalization of TNFRI from the cell surface and was reflected in the elimination of *induced* [Jun] kinase activity . Positive_regulation JUN TNF 12817708 1030724 Moreover , in ECs either presheared or remained in a static condition prior to stimulation by TNF-alpha while under shear flow , the ability of to *induce* [AP-1-DNA] binding activity in the nucleus was reduced . Positive_regulation JUN TNF 12881424 1116112 NF-kappaB downregulates *induced* [c-Jun N-terminal kinase (JNK)] activation that promotes cell death , but the mechanism is not yet fully understood . Positive_regulation JUN TNF 12893683 1135207 Electrophoretic mobility shift assay demonstrated that both GBE and probucol inhibited transcription factor nuclear factor-kappaB activation in TNF-alpha stimulated HAECs ( 55.2 % and 65.6 % inhibitions , respectively ) but only GBE could inhibit the *stimulated* [activator protein 1] activation ( 45.1 % inhibition , P < 0.05 ) . Positive_regulation JUN TNF 12947019 1151614 Because MEKK3 and Gab1 are critical for *induced* [c-Jun] and NF-kappaB activation , we determined the role of SHP-2 phosphatase activity in MEKK3 signaling . Positive_regulation JUN TNF 1331059 200232 Moreover , gel retardation analyses revealed that and IFN gamma synergistically *induced* the binding of NF-kB like as well as [AP-1] like proteins bound to these sites . Positive_regulation JUN TNF 14512437 1185702 *induced* a 3-fold increased activity of [c-JUN-N-terminal kinase (JNK)] 1 in d PC12 cells within 20 min that could be increased 5- to 8-fold by P together with TNFalpha . Positive_regulation JUN TNF 14530285 1174842 , which *activates* both NF-kappa B and [AP-1] , increased MAT2A expression in a dose- and time dependent manner , binding of both NF-kappa B and AP-1 to the MAT2A promoter and MAT2A promoter activity , with the latter effect blocked by site directed mutagenesis of the NF-kappa B and AP-1 binding sites . Positive_regulation JUN TNF 14607843 1200410 The induced *activation* of [c-Jun N-terminal kinase (JNK)] and p38 mitogen activated protein kinases ( MAPKs ) , however , was promoted by depletion of TRP14 but not by that of Trx1 . Positive_regulation JUN TNF 14617571 1209937 In vitro did not *increase* [c-Jun] and proliferation in granulosa cells from TNFR1 knockout mice . Positive_regulation JUN TNF 14617571 1209938 The time course of *induced* [c-Jun] revealed biphasic patterns of short-term ( 3 h ) and long-term ( 24 h ) induction . Positive_regulation JUN TNF 14617571 1209940 In conclusion , the above results demonstrate that increased c-Jun by activating stress activated protein kinase/c-Jun-NH ( 2 ) -teminal kinase signaling via TNFR1 in mouse granulosa cells , and the induced [c-Jun] *resulted* in increased cell proliferation . Positive_regulation JUN TNF 14661063 1218763 Keratinocyte derived acts as an endogenous tumour promoter and can also *regulate* [AP-1] activity in mouse epidermis . Positive_regulation JUN TNF 14711835 1225498 PTD-p65-P1 had no effect on *induced* [AP-1] activation . Positive_regulation JUN TNF 14720501 1197827 Ebselen inhibits *induced* [c-Jun] N-terminal kinase activation and adhesion molecule expression in endothelial cells . Positive_regulation JUN TNF 14720501 1197829 Extracellular signal regulated kinase ( ERK1/2 ) , [c-Jun N-terminal kinase (JNK)] and p38 were rapidly and significantly *activated* by in HUVEC . Positive_regulation JUN TNF 14720501 1197833 Finally , *induced* [activator protein-1 (AP-1)] and nuclear factor-kappaB (NF-kappaB) activation and resultant intracellular adhesion molecule-1 ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) expressions were inhibited by ebselen . Positive_regulation JUN TNF 14755547 1205633 Furthermore , the transactivation of *stimulated* NF-kappaB and [AP-1] was inhibited by U0126 treatment . Positive_regulation JUN TNF 14755547 1205641 Overexpression of RasN17 also abolished the *stimulated* NF-kappaB and [AP-1] activity . Positive_regulation JUN TNF 15044447 1251314 hCG treatment prevented the *dependent* NF-kappaB and [AP-1] activation , which paralleled a decrease in the phosphorylation and degradation of IkappaBalpha . Positive_regulation JUN TNF 15056867 1230150 It was found that overexpression of Tom1 suppresses activation of transcription factors , NF-kappaB and [AP-1] , *induced* by either IL-1beta or and that the VHS domain of Tom1 is indispensable for its suppressive activity . Positive_regulation JUN TNF 15087472 1258142 In addition , *increased* the binding activity of [activator protein-1 (AP-1)] and stimulated transcription of a reporter gene containing AP-1-responsive elements in chromaffin cells . Positive_regulation JUN TNF 15149634 1248420 IL-1 and *induced* egr-1 and all [AP-1] member expression , except fosB and junD . Positive_regulation JUN TNF 15226458 1268832 However , if zinc was added back , all PPAR agonists significantly downregulated the *mediated* induction of inflammatory transcription factors NF-kappaB and [AP-1] and significantly reduced the expression of their target genes , VCAM-1 and IL-6 . Positive_regulation JUN TNF 15322261 1286991 [AP-1-specific] DNA-protein binding activity was *increased* by , and the supershift assay identified the components of c-fos and c-jun. Extracellular signal regulated kinase ( ERK ) and p38 were involved in the c-fos mRNA expression , and c-Jun NH ( 2 ) -terminal kinase ( JNK ) was involved in the c-jun mRNA expression . Positive_regulation JUN TNF 15334063 1303807 In addition , inhibition of NF-kappaB by luteolin led to augmentation and prolongation of [c-Jun N-terminal kinase (JNK)] activation *induced* by . Positive_regulation JUN TNF 15454113 1301137 PA and *increased* the phosphorylation of extracellular signal regulated kinase ( ERK)-1/2 , p38-kinase , and [c-Jun N-terminal kinase (JNK)] by Western blotting . Positive_regulation JUN TNF 15474068 1318858 Electrophoretic mobility shift assay revealed that U0126 attenuated [activator protein-1 (AP-1)] activation *induced* by . Positive_regulation JUN TNF 15483420 1320515 Theaflavin also significantly reduced *mediated* DNA binding of [activator protein-1] . Positive_regulation JUN TNF 15492857 1321721 The *induced* activation of [c-Jun N-terminal kinase (JNK)] , p38 , and NF-kappaB was not affected by Delta-1 stimulation . Positive_regulation JUN TNF 15572687 1344375 Here we report that JNK1 , but not JNK2 , is essential for *induced* [c-Jun] kinase activation , c-Jun expression , and apoptosis . Positive_regulation JUN TNF 15616312 1357501 Within 6 h of exposure , and N-9 *triggered* NF-kappaB and [AP-1/cFos] activation and upregulated interleukins and an array of chemokines by vaginal and polarized cervical epithelial cells . Positive_regulation JUN TNF 15650394 1364036 Curcumin inhibited both H2O2- and mediated *activation* of NF-kappaB and [AP-1] , and IL-8 release . Positive_regulation JUN TNF 15683721 1370650 All three cytokines alone induced the activation of [AP-1] while IL-1beta and but not IFN-gamma *induced* the activation of NF-kappaB . Positive_regulation JUN TNF 15818692 1393480 *induced* activation of NF-kappaB and [AP-1] was decreased in the primary dermal fibroblasts with the C43S TNFRSF1A mutation . Positive_regulation JUN TNF 15881228 1406418 Sphingosine 1-phosphate acts as a signal molecule in ceramide signal transduction of *induced* [activator protein-1] in osteoblastic cell line MC3T3-E1 cells . Positive_regulation JUN TNF 15881228 1406419 We previously demonstrated that *stimulated* the production of [activation protein (AP)-1] , a transcriptional factor , in mouse osteoblastic MC3T3-E1 cells . Positive_regulation JUN TNF 15881228 1406428 The present study thus suggests that SPP acts as a signal molecule in ceramide dependent signal transduction in *induced* [AP-1] in osteoblastic MC3T3-E1 cells . Positive_regulation JUN TNF 15893134 1407515 In the process of the search for such a unique anti-hypertensive drug , we have recently found that azelnidipine , a newly developed and commercially used long acting dihydropyridine based calcium antagonist ( DHP ) , inhibited induced [activator protein-1] *activation* and interleukin-8 expression in human umbilical vein endothelial cells by suppressing NADPH oxidase mediated reactive oxygen species generation . Positive_regulation JUN TNF 16011481 1459394 *induces* NF-kappaB ( nuclear factor kappaB ) and [AP-1] ( activator protein 1 ) nuclear binding activities . Positive_regulation JUN TNF 16011481 1459400 Blocking NF-kappaB also lowered basal c-Jun expression and blunted the mediated *increase* in [c-Jun] mRNA levels . Positive_regulation JUN TNF 16023081 1441583 Ellagic acid inhibited IL-1beta- and *induced* activation of [activator protein-1] and mitogen activated protein kinases ( extracellular signal regulated kinase , c-Jun N-terminal kinase and p38 mitogen activated protein kinase ) , but not of nuclear factor-kappaB . Positive_regulation JUN TNF 16094077 1443623 also *activated* NF-kappaB , [AP-1] and ERK1/2 . Positive_regulation JUN TNF 16140265 1454785 We also found that SM-7368 strongly inhibits *induced* NF-kappaB activity but not [AP-1] activity . Positive_regulation JUN TNF 16141211 1467203 Differences in *induced* STAT3/DNA binding activity and not NFkappaB and [AP-1] transcriptional activation correlated with impaired collagen accumulation/TIMP-1 induction in TNFR2 ( -/- ) cells . Positive_regulation JUN TNF 16269458 1509290 On the other hand , and IL-1beta *induced* p38 , [c-Jun N-terminal kinase (JNK)] , and nuclear factor (NF)kappaB activation , pathways more closely related to stress response . Positive_regulation JUN TNF 16294327 1532384 Curcumin inhibited interleukin-1beta- and induced *activation* of activator protein-1 (AP-1) and mitogen activated protein ( MAP ) kinases ( ERK , [c-Jun N-terminal kinase (JNK)] , and p38 MAP kinase ) , but not of nuclear factor-kappaB (NF-kappaB) . Positive_regulation JUN TNF 16352630 1504291 We have previously reported that tumor necrosis factor receptor associated factor 1 ( TRAF1 ) , an intracellular protein , which binds to a range of molecules , including tumor necrosis factor (TNF) receptor family members , regulates *induced* NF-kappaB and [AP-1] signaling as well as TCR triggered proliferative responses in T cells . Positive_regulation JUN TNF 16358608 1492987 The electrophoretic mobility shift assay revealed that *triggered* [AP-1] and DNA binding and again , NS-398 and meloxicam inhibited this reaction via reducing c-Fos synthesis . Positive_regulation JUN TNF 16420740 1514808 In contrast , the broad-spectrum tyrosine kinase inhibitor genistein and the MEK-1 inhibitor ( PD98059 ) abrogated GM-CSF priming of release and *activation* of both NF-kappaB and [AP-1] . Positive_regulation JUN TNF 16424045 1515409 The other components of the TNF receptor I signaling cascade were not altered , whereas *induced* [c-Jun] NH ( 2 ) -terminal kinase activation and apoptosis were potentiated . Positive_regulation JUN TNF 16452391 1547910 Western blot analysis demonstrated that Syk inhibition by R406 markedly suppressed *induced* [c-Jun N-terminal kinase (JNK)] phosphorylation in FLS , with a modest decrease in extracellular signal regulated kinase phosphorylation . Positive_regulation JUN TNF 16581780 1543835 We recently reported that NS5A protein interacts with TRAF2 and modulates *induced* NF-kappaB and [Jun N-terminal protein kinase (JNK)] . Positive_regulation JUN TNF 16645635 1671987 *stimulated* both NF-kappaB and [c-Jun NH2-terminal kinase (JNK)] activities , which had opposite action on cell survival . Positive_regulation JUN TNF 16783201 1573688 Thermal injury also induces *dependent* delay apoptosis and TNF-alpha independent [AP-1] activation of neutrophil at 3 h after thermal injury . Positive_regulation JUN TNF 16835238 1606490 Analysis of differentiating epithelia showed that only well differentiated enterocytes activated the 4-kb long MLCK promoter in response to TNF , and consensus promoter reporters demonstrated that TNF induced NFkappaB activation decreased during differentiation while *induced* [AP-1] activation increased . Positive_regulation JUN TNF 16876162 1600871 Further , a dominant-inhibitory mutant of TRUSS inhibited *induced* [AP-1] activation . Positive_regulation JUN TNF 16876162 1600872 These findings suggest that TRUSS activates JNK in a TRAF2 dependent fashion and is involved in *induced* [AP-1] activation via JNK kinases . Positive_regulation JUN TNF 16895791 1597326 In agreement with these findings , EMSA shows a *induced* increase in [AP-1] and a decrease in Sp1 DNA binding . Positive_regulation JUN TNF 16924232 1692181 Among the MAPKs , it was interesting that whereas *induced* [c-Jun N-terminal kinase (JNK)] activation was abolished , activation of p44/p42 MAPK and p38 MAPK was potentiated in PKR deleted cells . Positive_regulation JUN TNF 16934229 1627285 However , during the past few years it has become clear that NF-kappaB mediated inhibition of cell death also involves attenuating *induced* activation of [c-Jun activating kinase (JNK)] . Positive_regulation JUN TNF 16959273 1646612 Emodin was determined to inhibit *induced* activation of [AP-1] promoter , an important nuclear transcription factor in MMP-1 expression . Positive_regulation JUN TNF 17028035 1654289 It was concluded that *activates* NF-kappaB and [AP-1] and induces PGE ( 2 ) release which alters dose-dependently the activity of the pump by activating different EP receptors with different affinities for PGE ( 2 ) . Positive_regulation JUN TNF 17082637 1643353 Although *stimulates* phosphorylation of [c-Jun] , the inhibition of JNK activity had no significant effect on FRA-1 induction . Positive_regulation JUN TNF 17110930 1651029 Inhibition of NF-kappaB activation increases susceptibility to *induced* cell death , concurrent with caspases and prolonged [c-Jun N-terminal kinase (JNK)] activation , and reactive oxygen species ( ROS ) accumulation . Positive_regulation JUN TNF 17126899 1677668 Stimulation of ECs with *induced* rapid increases in the phosphorylation of their mitogen activated protein kinases ( MAPKs ) [ extracellular signal regulated kinase ( ERK ) , [c-Jun-NH2-terminal kinase (JNK)] , and p38 MAPK ] ; Positive_regulation JUN TNF 17189827 1680092 while *increased* the activities of both NF-kappaB and [AP-1] . Positive_regulation JUN TNF 17189827 1680142 Stimulation of cells with *resulted* in the activation of mitogen activated protein kinases (MAPK) such as [c-Jun N-terminal kinase (JNK)] and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Positive_regulation JUN TNF 17214640 1681834 Roxithromycin significantly inhibited *induced* [c-Jun] N-terminal kinase activation ( JNP ) and marginally inhibited extracellular signal regulated kinase ( ERK ) 1/2 activation , but not p38 mitogen activated protein kinase activation . Positive_regulation JUN TNF 17227768 1703822 We tested whether mitogenic activated protein kinase kinase kinase kinase isoform 4 ( MAP4K4 ) causes the *induced* negative regulation of extracellular signal regulated kinase-1/2 ( ERK-1/2 ) , [c-Jun NH2-terminal kinase (JNK)] , and the insulin receptor substrate-1 (IRS-1) on the insulin signaling pathway governing glucose metabolism . Positive_regulation JUN TNF 17241124 1696460 Combined and NMDA stimulation *results* in a transient increase in activity of extracellular signal regulated kinases ( ERKs ) and [c-Jun N-terminal kinases (JNKs)] . Positive_regulation JUN TNF 17322278 1747579 *induced* CD38 expression in human airway smooth muscle cells : role of MAP kinases and transcription factors NF-kappaB and [AP-1] . Positive_regulation JUN TNF 17401435 1741964 1,25 ( OH ) ( 2 ) D ( 3 ) inhibited *induced* phosphorylation of [c-Jun] without affecting phosphorylation of the other pathways . Positive_regulation JUN TNF 17424890 1723877 c-Fos and [c-Jun] mRNAs were *induced* by , and PD98059 ( MEK inhibitor ) and SB203580 ( p38 inhibitor ) abolished the up-regulation of c-Fos . Positive_regulation JUN TNF 17424890 1723878 EMSA revealed that *increased* [AP-1/DNA] binding , and PD98059 and SB203580 attenuated this reaction , possibly via reducing c-Fos synthesis . Positive_regulation JUN TNF 17438336 1749083 FAK was not required for *mediated* nuclear factor-kappaB or [c-Jun] N-terminal kinase activation . Positive_regulation JUN TNF 17467021 1743421 We also demonstrated that intracellular glutathione does not modulate the activation of MAPKs and/or their downstream [AP-1] *induced* by lower . Positive_regulation JUN TNF 17467021 1743422 Although [AP-1] *activation* by the lower was not detected in our systems , we could not rule out the possible involvement of transiently activated MAPKs/AP-1 in the regulation of TNF-alpha induced adhesion molecule expression . Positive_regulation JUN TNF 17635674 1798716 However , both cocaine and independently *increased* [phospho-c-Jun] NH ( 2 ) -terminal kinase and Bax levels at concurrent time periods ( 30 min and 1 h ) , and this elevation was attenuated in the presence of nTNF-alpha . Positive_regulation JUN TNF 17640567 1771204 The suppression of *induced* [AP-1] activation by curcumin was also reversed by glutathione . Positive_regulation JUN TNF 17786542 1842684 Here we show ( i ) that fluorescently labeled MIF is internalized by NIH 3T3 cells within minutes , ( ii ) compromises the *induction* of [phospho-c-Jun] levels by and PMA and , hence , is biologically active , but ( iii ) is not able to interfere with co-activation by Jab1/CSN5 of the androgen receptor . Positive_regulation JUN TNF 17895408 1823960 IA did not interfere with induced *activation* of [c-Jun N-terminal kinase (JNK)] and p38 mitogen activated protein kinase . Positive_regulation JUN TNF 17897957 1824018 Furthermore , overexpression of a dominant negative mutant of TAK1 blocked the *induced* expression of MMP-9 and activation of NF-kappaB and [AP-1] . Positive_regulation JUN TNF 18187553 1895249 Exogenous infusion *increased* [c-Jun] N-terminal kinase phosphorylation and insulin receptor substrate-1 serine 307 phosphorylation , and inhibited insulin induced signaling in liver . Positive_regulation JUN TNF 18274729 1891259 binding *induces* receptor trimerization , activation of [c-Jun N-terminal kinase (JNK)] , and induction of downstream transcription factors . Positive_regulation JUN TNF 18287248 1896520 Flavopiridol suppresses induced *activation* of [activator protein-1] , c-Jun N-terminal kinase , p38 mitogen activated protein kinase (MAPK) , p44/p42 MAPK , and Akt , inhibits expression of antiapoptotic gene products , and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells . Positive_regulation JUN TNF 18287248 1896535 is a potent *inducer* of [activator protein-1 (AP-1)] , and flavopiridol abrogated this activation in a dose- and time dependent manner . Positive_regulation JUN TNF 18336259 1881558 Since *activates* NF-kappaB and [AP-1] , we investigated the role of exogenous Nef protein in TNFalpha stimulated U937 cells and primary macrophages . Positive_regulation JUN TNF 18336259 1881561 We observed that exogenous Nef and synergistically *activate* NF-kappaB and [AP-1] in U937 cells and primary macrophages resulting in enhanced stimulation of the HIV-1 long terminal repeat ( LTR ) , and subsequently in enhanced viral replication in both chronically infected promonocytic U1 cells and acutely HIV-1 infected primary macrophages . Positive_regulation JUN TNF 18357389 1887724 The transactivation of *stimulated* NF-kappaB , [AP-1] and Sp-1 were inhibited by U0126 and SB203580 treatment . Positive_regulation JUN TNF 18467203 1921433 EMSA showed that IL-1beta and *activated* NF-kappaB and [AP-1] in MG-63 cells . Positive_regulation JUN TNF 18599158 2208601 and ( 3 ) S100B/RAGE induced upregulation of COX-2 , IL-1beta and expression *requires* the concurrent activation of NF-kappaB and [AP-1] . Positive_regulation JUN TNF 18675330 1960770 *induces* [activating protein 1 (AP-1)] activation via phosphorylation of mitogen activated protein kinases ( MAPKs ) . Positive_regulation JUN TNF 18720042 1961610 We were able to show that IFN-gamma , TGF-beta(1) and all *increased* the binding activity of transcription factor AP-1 ( [AP-1] ) . Positive_regulation JUN TNF 19013539 2071198 Furthermore , Western blot analysis indicated that the *induced* phosphorylation of extracellular signal regulated kinase 1 and 2 ( ERK1/2 ) , p38 and [c-Jun N-terminal kinase (JNK)] were strongly inhibited by DPT . Positive_regulation JUN TNF 19026990 2022784 The *activation* of [activator protein-1] by was inhibited by myricetin in a dose dependent manner . Positive_regulation JUN TNF 19052522 1999725 Therefore , we further examined the effects of BBR on *induced* [AP-1] DNA binding activity which is a downstream target of ERK and p38 . Positive_regulation JUN TNF 19052522 1999726 Our data showed that *induced* [AP-1] DNA binding activity was inhibited by BBR . Positive_regulation JUN TNF 19166983 2038537 3 h after resuscitation , pulmonary capillary leakage and wet/dry weight ratio , levels of , interleukin (IL)-6 , malondialdehyde ( MDA ) , oxidized and reduced glutathione ( GSH and GSSG ) , myeloperoxidase (MPO) activity , nuclear factor (NF)-kappaB , [activator protein (AP)-1] *activation* , and lung microscopic and ultrastructural histological changes were measured . Positive_regulation JUN TNF 19228941 2044727 Increasing evidence demonstrates that interleukin (IL)-32 is a pro-inflammatory cytokine , *inducing* IL-1alpha , IL-1beta , IL-6 , , and chemokines via nuclear factor (NF)-kappaB , p38 mitogen activated protein kinase (MAPK) , and [activating protein (AP)-1] activation . Positive_regulation JUN TNF 19235541 2079546 Exposure to cigarette smoke upregulates [AP-1] activity and *induces* overexpression in mouse lungs . Positive_regulation JUN TNF 19243468 2240655 We report here that HSP70 over-expression in human colon cancer cells can inhibit TNFalpha induced NFkappaB activation but promote *induced* activation of [c-Jun N-terminal kinase (JNK)] through interaction with TNF receptor (TNFR) associated factor 2 ( TRAF2 ) . Positive_regulation JUN TNF 19376732 2081871 Although *increased* DNA binding activity of Ref-1 regulated transcription factors , [AP-1] and NF-kappaB , to the IL-8 promoter , promoter activity was mainly mediated by NF-kappaB binding . Positive_regulation JUN TNF 19376732 2081879 Silencing of Ref-1 in AGS cells inhibited basal and *induced* [AP-1] and NF-kappaB DNA binding activity , but not their nuclear accumulation . Positive_regulation JUN TNF 19429670 2106931 Moreover , Ang II enhanced the activation of [AP-1] ( c-fos ) *induced* by . Positive_regulation JUN TNF 19473519 2091165 The gel shift and promoter activity assay showed that TNF-alpha increased AP-1 binding activity and resistin promoter activity , while SP600125 and atorvastatin inhibited the [AP-1] binding activity and resistin promoter activity *induced* by . Positive_regulation JUN TNF 19553068 2104009 Using luciferase reporter assays , we demonstrated that significantly *increased* [activator protein-1 (AP-1)] transcriptional activity in the MCF7 cells . Positive_regulation JUN TNF 19563733 2122003 Finally , EZS inhibited *induced* p38 MAPK and [c-Jun N-terminal kinase (JNK)] phosphorylation . Positive_regulation JUN TNF 19800320 2153888 however , it enhanced *induced* expression of intracellular adhesion molecule (ICAM)-1 as well as activation of [c-Jun N-terminal kinase (JNK)] . Positive_regulation JUN TNF 19838780 2216992 In the present study , production of and MIP-2 and *activation* of extracellular signal regulated kinases ( ERK ) 1/2 , [c-Jun amino terminal kinases (JNK)] and p38 in RAW264.7 cells were measured . Positive_regulation JUN TNF 19918265 2190011 Mixed lineage kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase that is *activated* by and specifically activates [c-Jun N-terminal kinase (JNK)] on TNF-alpha stimulation . Positive_regulation JUN TNF 20138622 2280971 N-acetylcysteine , SP600125 ( JNK inhibitor ) and SB203580 ( p38 MAPK inhibitor ) attenuated *induced* DNA binding activities of both [AP-1] and NF-kappaB . Positive_regulation JUN TNF 20141610 2178971 *induced* increased levels of [c-Jun] and C-Fos in the nucleus accompanied by phosphorylation of c-Jun . Positive_regulation JUN TNF 20141610 2178972 Together , these results suggest that *induces* expression and DNA binding of [AP-1] resulting in increased transcription of the TGF-beta(1) gene . Positive_regulation JUN TNF 20333651 2266140 On the other hand , *stimulated* the phosphorylation of c-Src , EGFR , Akt , JNK1/2 , and [c-Jun] , which were inhibited by pretreatment with Gö6983 . Positive_regulation JUN TNF 20333651 2266153 Pretreatment with the inhibitor of JNK1/2 ( SP600125 ) but not the inhibitor of MEK1/2 ( U0126 ) , p38 MAPK ( SB202190 ) , or PI3K ( LY294002 ) , markedly inhibited *induced* [c-Jun] mRNA levels . Positive_regulation JUN TNF 20837364 2368510 In a cell line of canine epidermal keratinocyte , CPEK , stimulation with *induced* not only the activation of nuclear factor-kappa B ( NF-?B ) but also the phosphorylation of [c-Jun-N-terminal kinase (JNK)] and mitogen activated protein kinase p38 ( p38 ) . Positive_regulation JUN TNF 20943792 2347877 Quercetin and trans-RSV attenuated *mediated* phosphorylation of [c-Jun] and degradation of inhibitory ?B protein . Positive_regulation JUN TNF 21072492 2366054 GM3 synthase gene expression markedly suppressed the *stimulated* transcriptional activity of [activator protein-1 (AP-1)] and nuclear factor-?B ( NF-?B ) , which are the controlling factors of MMP-9 expression . Positive_regulation JUN TNF 21136335 2355911 PDGF-BB and *activated* [AP-1] , which was also inhibited by DMF . Positive_regulation JUN TNF 21181166 2499599 IL-1ß and *activated* the intracellular mitogen activated protein kinases ( MAPKs ) : p44/42 MAPK , p38 , and [c-Jun N-terminal kinase (JNK)] as well as nuclear factor-?B ( NF-?B ) in osteoblasts . Positive_regulation JUN TNF 21334436 2415225 It also diminished *induced* reactive oxygen species ( ROS ) accumulation and subsequent activation of [c-Jun NH2-terminal kinase (JNK)] , which regulates the DNA binding activities of both AP-1 and NF-?B required for ET-1 gene transcription . Positive_regulation JUN TNF 21705614 2465730 Furthermore , luteolin inhibited *induced* phosphorylation of mitogen activated protein kinase/extracellular signal regulated kinase ( ERK ) kinase 1/ERK/p90 ( RSK ) , mitogen activated protein kinase kinase 4/c-Jun N-terminal [kinase/c-Jun] , and Akt/p70 ( S6K ) . Positive_regulation JUN TNF 21777697 2509920 However , ZLJ-6 did not affect *induced* extracellular signal regulated kinases ( ERK1/2 ) , [c-Jun N-terminal kinases (JNK)] and p38 phosphorylation . Positive_regulation JUN TNF 22155163 2568525 Furthermore , sulforaphane inhibited NK-?B and [AP-1] activation *induced* by . Positive_regulation JUN TNF 22198289 2558672 Stimulation of human umbilical vein endothelial cells ( HUVEC ) with IL-1ß or ( CHX ) was found to *enhance* the phosphorylation of p38 and [Jun-N-terminal kinase (JNK)] in a time dependent fashion , but did not affect the time dependent phosphorylation of extracellular signal regulated kinase . Positive_regulation JUN TNF 22198289 2558690 In addition , IL-1ß and *induced* the phosphorylation of activating transcription factor-2 ( ATF-2 ) , but not [c-Jun] . Positive_regulation JUN TNF 22199367 2558743 Aged SOD2+/- SMCs had attenuated insulin-like growth factor-1 induced Akt and Forkhead box O3a phosphorylation and prolonged *induced* [Jun] N-terminal kinase 1 activation . Positive_regulation JUN TNF 22219201 2559056 receptor associated factor 7 is *required* for TNFa induced [Jun] NH2-terminal kinase activation and promotes cell death by regulating polyubiquitination and lysosomal degradation of c-FLIP protein . Positive_regulation JUN TNF 22343222 2617799 Using immunohistological techniques , we showed a higher epithelial expression of , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and [activator protein-1/mitogen] activated protein kinase signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation JUN TNF 22510373 2613329 In rat aortic endothelial cells , relaxin activated protein kinase B ( Akt ) and repressed *induced* nuclear factor-?B and [activator protein-1] . Positive_regulation JUN TNF 22711527 2670038 *mediated* [AP-1-luciferase] activity and c-Jun binding to the AP-1 element were inhibited by TNFR1 Ab , thioredoxin , SP600125 , and SB203580 . Positive_regulation JUN TNF 22773691 2659880 In human ASM ( HASM ) cells , *induces* CD38 expression through activation of MAPKs , NF-?B , and [AP-1] , and its expression is differentially elevated in cells from asthmatic patients compared with cells from nonasthmatic subjects . Positive_regulation JUN TNF 22941947 2678500 In *response* to interleukin-1 , , and toll-like receptor agonists , it mediates the activation of the nuclear factor ?B ( NF-?B ) , [c-Jun N-terminal kinase (JNK)] , and p38 pathways . Positive_regulation JUN TNF 23071098 2720895 Mixed-effects modeling analysis of our data was vital for ascertaining that IL-1a and TGF-a treatment increased the activities of more pathways than IL-6 and TNF-a and that TGF-a and *increased* p38 MAPK and [c-Jun N-terminal kinase (JNK)] phospho-protein levels in a synergistic manner . Positive_regulation JUN TNF 23152905 2699889 It inhibited [c-Jun N-terminal kinase (JNK)] activation *induced* by dexamethasone and/or and increased levels of GR localized to the nucleus . Positive_regulation JUN TNF 23250032 2737200 Baculoviral inhibitors of apoptosis repeat containing ( BIRC ) proteins fine-tune *induced* nuclear factor ?B and [c-Jun] N-terminal kinase signalling in mouse pancreatic beta cells . Positive_regulation JUN TNF 23319318 2733173 *increased* DNA binding activity of [AP-1] and NF-?B , whereas both AP-1 and NF-?B decoy oligodeoxynucleotides downregulated TNF-a induced MCP-1 mRNA expression . Positive_regulation JUN TNF 23319318 2733177 MPA and Syk inhibitor attenuated *induced* DNA binding activity of NF-?B and [AP-1] . Positive_regulation JUN TNF 23353699 2754249 Finally , we showed that , in H9c2 cells , *stimulated* [AP-1] promoter activity , c-Jun mRNA expression , and c-Jun phosphorylation were attenuated by PP1 , AG1478 , AG1296 , LY294002 , SB202190 , SP600125 , or U0126 . Positive_regulation JUN TNF 23558031 2818883 *induced* phosphorylation of JNK and [c-Jun] was sustained by p38 inhibitors in monocytes , primary macrophages and FLS . Positive_regulation JUN TNF 23784308 2887320 Furthermore , in mice we observed that CpdA instigates a strong enhancement of *induced* [AP-1-driven] gene expression . Positive_regulation JUN TNF 24069158 2847001 In addition , also *stimulated* [c-Jun] and ATF2 phosphorylation which were inhibited by pretreatment with SP600125 and SB202190 , respectively , but not PD98059 . Positive_regulation JUN TNF 24225134 2897476 Furthermore , TTM dose-dependently inhibited *induced* activation of NF-?B and [AP-1] , as well as mRNA and protein expression of VCAM-1 , ICAM-1 , and MCP-1 , which was abolished by preincubating the cells with 5 µM TTM and 15 µM cupric sulfate . Positive_regulation JUN TNF 24361597 2911254 *stimulated* [AP-1] activation , including c-Jun and ATF2 phosphorylation and AP-1 transcription activity via MAPK dependent pathways . Positive_regulation JUN TNF 24587316 2920290 induced also an *increase* in [AP-1] DNA binding activity and the antiapoptotic effect of TNF-a was potentiated by inhibitors of AP-1 , SR 11302 and tanshinone IIA and by an inhibitor of c-jun-N-terminal kinase , SP600125 , which is an upstream kinase activating AP-1 . Positive_regulation JUN TNF 7917514 269826 Secretion of IL-2 and TNF-alpha , surface expression of IL-2R , and DNA binding activity of NF-kappa B and [AP-1] ( Fos/Jun ) complex in *response* to phorbol myristate acetate , , or immobilized antibodies to CD3 were monitored . Positive_regulation JUN TNF 7935377 275813 Consistent with this possibility , IL-1 and markedly *increase* the binding of Fos and [Jun] to the AP-1 site , and NF-IL6 activates the native TSG-6 promoter . Positive_regulation JUN TNF 8361227 227852 The mitogenic response of AML blasts to *requires* functional [c-jun/AP-1] . Positive_regulation JUN TNF 8430810 212756 In addition , IL-6 , , and IL-1 beta , cytokine regulators of the acute phase response , *stimulated* expression of an [AP-1] responsive reporter gene introduced by DNA mediated transfection into adult rat hepatocytes in primary culture . Positive_regulation JUN TNF 8923461 397259 These results suggest that , probably acting through ceramide formation , *stimulates* the binding of both c-fos and c-jun to the [AP-1] element upstream of exon 1.4 . Positive_regulation JUN TNF 9006914 410772 stimulation of endothelial cells *induces* transient phosphorylation of both ATF-2 and [c-JUN] and induces marked activation of the c-JUN N-terminal kinase ( JNK1 ) and p38 but not extracellular signal regulated kinase ( ERK1 ) . Positive_regulation JUN TNF 9096313 422376 Sodium salicylate induces apoptosis via p38 mitogen activated protein kinase but inhibits *induced* [c-Jun] N-terminal kinase/stress activated protein kinase activation . Positive_regulation JUN TNF 9149909 430095 Secreted *mediated* the enhancement of nuclear factor kappa B (NF-kappa B) and [activator protein-1 (AP-1)] binding activity ; Positive_regulation JUN TNF 9317150 456270 In human endothelial cells , rapidly *induces* N-terminal domain phosphorylation of both [c-Jun] and ATF2 . Positive_regulation JUN TNF 9368689 463887 *increased* [c-Jun] protein , but only weakly induced FOS proteins ( c-Fos , FosB , Fra-1 , and Fra-2 ) whereas cAMP increased the abundance of several FOS proteins ( c-Fos , FosB , Fra-1 , and Fra-2 ) , with little effect on c-Jun levels . Positive_regulation JUN TNF 9368689 463889 Cyclic AMP alone induced AP-1-responsive reporter ( p3TPLUX ) activity threefold after 2 h with peak effect of 4-fold at 4 hr . AP-1 reporter was not induced by alone but in the presence of cAMP , TNF alpha *induced* [AP-1] reporter activity 12-fold . Positive_regulation JUN TNF 9427646 481711 In addition , GFP-DeltaFADD did not interfere with mediated gene induction or with *activation* of NF-kappaB or [Jun N-terminal kinase (JNK)] , demonstrating that FADD is part of the TNFR60 initiated apoptotic pathway but does not play a role in TNFR60 mediated gene induction . Positive_regulation JUN TNF 9439980 475065 Curcumin inhibits IL1 alpha and *induction* of [AP-1] and NF-kB DNA binding activity in bone marrow stromal cells . Positive_regulation JUN TNF 9439980 475075 IL1 alpha and rapidly *induced* both [AP-1] and NF-kB DNA binding activities in +/+ ( - ) 1.LDA11 stromal cells . Positive_regulation JUN TNF 9481405 487706 *increased* c-jun and junD mRNA and [c-Jun] and JunD protein levels , as well as AP-1 binding activity . Positive_regulation JUN TNF 9481405 487710 *increases* both [c-Jun] and JunD , whereas IL-6 stimulates only c-Jun . Positive_regulation JUN TNF 9531270 496768 Overexpression of the p80 TNF receptor leads to *dependent* apoptosis , nuclear factor-kappa B activation , and [c-Jun] kinase activation . Positive_regulation JUN TNF 9731197 530444 *activates* the expression of [activator protein-1 (AP-1)] responsive genes . Positive_regulation JUN TNF 9731197 530445 We show here that over-expression of TxP-1 blocks *induced* [AP-1] activation in endothelial ECV304 cells , which was demonstrated by three independent experimental protocols : electromobility shift assay with AP-1 oligonucleotide probe ; Positive_regulation JUN TNF 9743347 532413 *induced* activation of another nuclear transcription factor , [AP-1] , was suppressed by IL-13 . Positive_regulation JUN TNF 9743347 532423 Thus , overall , these results demonstrate that IL-13 is a potent inhibitor of *mediated* activation of NF-kappa B , [AP-1] , and apoptosis , which may contribute to its previously described immunosuppressive and anti-inflammatory effects . Positive_regulation JUN TNF 9830008 551250 H2O2 and *induce* differential binding of the redox-responsive transcription factors [AP-1] and NF-kappaB to the interleukin-8 promoter in endothelial and epithelial cells . Positive_regulation JUN TNF 9830008 551271 H2O2 activated AP-1 but not NF-kappaB in A549 , whereas *activated* [AP-1] as well as NF-kappaB . Positive_regulation JUN TNF 9830008 551274 In HMEC-1 , *activated* NF-kappaB but not [AP-1] , while H2O2 did not activate either transcription factor . Positive_regulation JUN TNF 9830008 551279 Supershift analysis revealed H2O2 as well as *induced* [AP-1] complexes containing c-Fos and JunD . Positive_regulation JUN TNFSF10 10811114 692995 Treatment of PC-3 cells with also *activated* [c-Jun NH2-terminal kinase 1 (JNK1)] ; Positive_regulation JUN TNFSF10 10958661 724871 Although it is known that ( Apo2L ) induces apoptosis and *activates* NF-kappaB and [Jun N-terminal kinase (JNK)] through receptors such as TRAIL-R1 ( DR4 ) and TRAIL-R2 ( DR5 ) , the components of its signaling cascade have not been well defined . Positive_regulation JUN TNFSF10 12807432 1101895 rapidly ( from 20 min ) *induced* the phosphorylation of Akt and ERK , but not of [c-Jun NH2-terminal kinase (JNK)] . Positive_regulation JUN TNFSF10 19483299 2085939 A771726 did not increase the expression of TRAIL receptors in LX-2 cells but could inhibit activation of the c-Jun NH2-terminal kinase (JNK) pathway through decreasing *induced* JNK and [c-Jun] phosphorylation . Positive_regulation JUN TNFSF10 21152872 2373383 We found that MEKK1/MEKK4 as opposed to ASK1 , are responsible for *induced* [c-Jun NH2-terminal kinase (JNK)] or p38 activation , and that their catalytic activity is repressed by the caspase-8 inhibitor , suggesting that the caspase-8 activation induced by TRAIL is indispensible for MEKK activation . Positive_regulation JUN TNFSF10 9830064 551396 In this study we show that ( tumor necrosis factor related apoptosis inducing ligand ) , also called Apo2L , *activates* the [c-Jun N-terminal kinase (JNK)] . Positive_regulation JUNB EPHB2 17341624 1665100 In contrast , [JunB] is *activated* by the MAP kinase for the AP-1 subunits c-Jun and JunB to mediate VEGF regulaltion of hypoglycemia . Positive_regulation JUNB IL1B 15677771 1395418 similarly *increased* [JunB] expression in fibroblasts from patients with IPF and control subjects . Positive_regulation JUNB MAP2K6 9858557 582189 In cells expressing a conditionally active form of Raf-1 ( DeltaRaf-1 : ER ) , we observed that selective , sustained activation of was *sufficient* to induce expression of Fra-1 , Fra-2 , and [JunB] but , interestingly , induced little or no c-Fos or c-Jun . Positive_regulation JUNB TNF 10858536 730028 Whilst the expression of JunD was not affected by any of the mediators , the mRNA levels of c-fos and [JunB] were *induced* by LPS , IL-6 , IFN-gamma , PDGF and , and that of c-jun by LPS , IFN-gamma , PDGF and TNF-alpha . Positive_regulation JUND EPHB2 12226747 988035 We show that Menin inhibits *dependent* phosphorylation and activation of both [JunD] and the Ets-domain transcription factor Elk-1 . Positive_regulation JUND EPHB2 14676207 1211130 Here we show that these motifs mediate [JunD] phosphorylation in *response* to either or JNK activation . Positive_regulation JUND TNF 9481405 487707 *increased* c-jun and junD mRNA and c-Jun and [JunD] protein levels , as well as AP-1 binding activity . Positive_regulation JUND TNF 9481405 487711 *increases* both c-Jun and [JunD] , whereas IL-6 stimulates only c-Jun . Positive_regulation KANK2 EPHB2 19723624 2152278 [SIP30] is *regulated* by in peripheral nerve injury induced neuropathic pain . Positive_regulation KANK2 EPHB2 19723624 2152280 In PC12 cells , up-regulation of [SIP30] by nerve growth factor is also *dependent* on activation . Positive_regulation KANK2 TNF 14566398 1155051 ( 3 ) in Balb/c 3T3 cells dexamethasone and TNF-alpha acted synergistically to induce the expression of SIP24/24p3 , whereas in BNL cells dexamethasone and *induced* the expression of [SIP24/24p3] in an additive manner ; Positive_regulation KANK4 EGF 18458160 1909405 The interaction between [Kank] and 14-3-3 is *regulated* by insulin and and is mediated through phosphorylation of Kank by Akt . Positive_regulation KANK4 INS 18458160 1909406 The interaction between [Kank] and 14-3-3 is *regulated* by and EGF and is mediated through phosphorylation of Kank by Akt . Positive_regulation KARS TNF 15851690 1404033 Among them , we found that [lysyl-tRNA synthetase] ( KRS ) was secreted from intact human cells , and its secretion was *induced* by . Positive_regulation KAT2B EPHB2 24409148 2900632 Once activated , can *trigger* [chromatin remodeling] and induce gene expression that permits long-term cellular alterations and drug induced morphological and behavioral changes . Positive_regulation KAT2B FOXA1 19687299 2138972 This *mediated* [chromatin remodeling] does not induce MMTV transcription , as opposed to that of the GR . Positive_regulation KAT2B FOXO1 20041807 2211210 Akt induced phosphorylation of is *required* for its binding to [PCAF] , whereas the binding between FOXO1 and CBP is independent on FOXO1 S253 phosphorylation . Positive_regulation KAT2B MAP2K6 15025563 1257120 CBP and [P/CAF] inductions of the involucrin expression were not *dependent* on ( mitogen activated protein kinase/extracellular-signal regulated kinase kinase ) , p38 , protein kinase C or CaM kinase ( calcium/calmodulin dependent kinase ) signalling . Positive_regulation KAT2B MAP2K6 17077328 1693093 In the *presence* of inhibitors , however , retinoid induced [chromatin remodeling] , target-gene transcription , and granulocytic differentiation are strikingly inhibited and apoptosis induction becomes independent of death inducing ligand/receptor pairs ; Positive_regulation KAT2B STAT4 14660657 1202260 is *required* for interleukin-12 induced [chromatin remodeling] of the CD25 locus . Positive_regulation KAT2B STAT4 14660657 1202289 In this report , we utilize chromatin immunoprecipitation assays to analyze IL-12 stimulated and *dependent* changes in [chromatin remodeling] of the CD25 gene . Positive_regulation KAT2B TLR7 20974955 2344119 Our results suggest that IFN-? overcomes endotoxin tolerance by facilitating *induced* [chromatin remodeling] to allow expression of proinflammatory genes . Positive_regulation KAT2B TNF 14622953 1169200 p300 and its associated factor [PCAF] levels but not Srb7 , Med7 , or TFII ( B ) were *increased* by phorbol ester or alpha stimulation . Positive_regulation KAT7 CCND1 18399550 1893743 Overexpression of [ING4] can induce growth inhibition in A549 cells both in vitro and in vivo , and also *induce* up-regulation of p27 , down-regulation of , SKP2 , and Cox2 , and inactivation of the Wnt-1/beta-catenin pathway . Positive_regulation KAT8 TNF 16386180 1494192 Cytokines are the direct mediators for multiple organ failure (MOF) , and [MOF] is *triggered* by and a cascade of cytokine release , with a prolonged high-expression of IL-6 . Positive_regulation KCNA2 KCNE1 19623261 2112616 Membrane surface biotinylation assays showed that surface expression of [Kv12] .2 was significantly *increased* by and KCNE3 siRNA , whereas total protein expression of Kv12 .2 was not affected . Positive_regulation KCNAB1 TNF 15814698 1393106 Although LPS increased Kv beta1 .3 , reduced Kv beta1 .2 , and maintained Kv beta1 .1 mRNA levels constant , *up-regulated* [Kv beta1] .1 , down-regulated Kv beta1 .2 , and left Kv beta1 .3 expression unchanged . Positive_regulation KCNE1 BACE1 23504710 2787692 Elevated a-secretase or activities *increased* C-terminal fragment (CTF) levels of [KCNE1] and 2 in human embryonic kidney ( HEK293T ) and rat neuroblastoma ( B104 ) cells . Positive_regulation KCNE1 BACE1 23504710 2787694 Together , these results clearly showed that [KCNE1] and KCNE2 cleavages are *regulated* by and PS/?-secretase activities under physiological conditions . Positive_regulation KCNE1 KCNE4 18709386 2028165 was the most abundant ( p < 0.0001 ) , and KCNQ1 , KCNQ5 and [KCNE1] were *up-regulated* in metestrous ( p < 0.0001 ) . Positive_regulation KCNE1 PRKAA1 21231794 2379622 The present study explored whether *regulates* [KCNQ1/KCNE1] . Positive_regulation KCNE1 PRKAA2 21231794 2379623 The present study explored whether *regulates* [KCNQ1/KCNE1] . Positive_regulation KCNE1 PRKAB1 21231794 2379624 The present study explored whether *regulates* [KCNQ1/KCNE1] . Positive_regulation KCNE1 PRKAB2 21231794 2379625 The present study explored whether *regulates* [KCNQ1/KCNE1] . Positive_regulation KCNE1 PRKACB 19077539 2041948 beta-adrenergic receptor mediated IKs upregulation , a functional consequence of phosphorylation of the KCNQ1 amino terminus ( N-T ) , *requires* co-expression of KCNQ1/Yotiao with [KCNE1] . Positive_regulation KCNE1 PRKACG 19077539 2041949 beta-adrenergic receptor mediated IKs upregulation , a functional consequence of phosphorylation of the KCNQ1 amino terminus ( N-T ) , *requires* co-expression of KCNQ1/Yotiao with [KCNE1] . Positive_regulation KCNE1 PRKAG1 21231794 2379626 The present study explored whether *regulates* [KCNQ1/KCNE1] . Positive_regulation KCNE1 PRKAG2 21231794 2379627 The present study explored whether *regulates* [KCNQ1/KCNE1] . Positive_regulation KCNE1 PRKAR1A 19077539 2041950 beta-adrenergic receptor mediated IKs upregulation , a functional consequence of phosphorylation of the KCNQ1 amino terminus ( N-T ) , *requires* co-expression of KCNQ1/Yotiao with [KCNE1] . Positive_regulation KCNE1 PRKAR1B 19077539 2041951 beta-adrenergic receptor mediated IKs upregulation , a functional consequence of phosphorylation of the KCNQ1 amino terminus ( N-T ) , *requires* co-expression of KCNQ1/Yotiao with [KCNE1] . Positive_regulation KCNE1 PRKAR2A 19077539 2041952 beta-adrenergic receptor mediated IKs upregulation , a functional consequence of phosphorylation of the KCNQ1 amino terminus ( N-T ) , *requires* co-expression of KCNQ1/Yotiao with [KCNE1] . Positive_regulation KCNE1 PRKAR2B 19077539 2041953 beta-adrenergic receptor mediated IKs upregulation , a functional consequence of phosphorylation of the KCNQ1 amino terminus ( N-T ) , *requires* co-expression of KCNQ1/Yotiao with [KCNE1] . Positive_regulation KCNE1 SCARB2 16901941 1625775 Although LIMP2 is normally expressed in all cells of the stria vascularis , in the organ of Corti and cochlear neurons , the lack of preferentially *caused* a loss of [KCNQ1/KCNE1] and megalin , and structural changes were only seen months later , indicating that these proteins are highly sensitive to disturbances in the lysosomal pathway . Positive_regulation KCNH2 KCNE1 21856740 2496229 Coexpression of or KCNE2 did not *attenuate* this NS1643 effect on [erg1] channel activation and did thus not mimic the lower drug potency on this parameter observed in oocytes . Positive_regulation KCNH4 EPHB2 10637505 577447 activation *induces* phosphorylation of [Elk-1] at multiple S/T-P motifs to high stoichiometry . Positive_regulation KCNH4 EPHB2 10813377 693232 We used GAL-Elk-1 expression plasmids to detect *dependent* activation of [Elk-1] . Positive_regulation KCNH4 EPHB2 11283246 799354 ( ii ) interfering mutants of Ras and Rap1 both inhibit ERK kinase activity and *dependent* [Elk1] transcriptional activation in response to TPO ; Positive_regulation KCNH4 EPHB2 11756441 916243 In addition , cell-permeable peptides inhibited *mediated* activation of the transcriptional activity of [ELK1] . Positive_regulation KCNH4 EPHB2 11997521 939455 The constitutively active mutant of SHP-2 induces hyper-tyrosyl phosphorylation of FRS-2 alpha but fails to stimulate or potentiate either FGF-2 induced activation or [Elk-1] *transactivation* . Positive_regulation KCNH4 EPHB2 12008033 940714 We compared the BCR *induced* intracellular [ Ca2+ ] transient , protein tyrosine phosphorylation and phosphorylation , furthermore , the activation of [Elk-1] and CREB transcription factors . Positive_regulation KCNH4 EPHB2 12226747 988036 We show that Menin inhibits dependent phosphorylation and *activation* of both JunD and the Ets-domain transcription factor [Elk-1] . Positive_regulation KCNH4 EPHB2 12887893 1116955 pathway activation *leads* to both phosphorylation of [Elk-1] and loss of SUMO conjugation and , hence , to the loss of the repressive activity of the R motif . Positive_regulation KCNH4 EPHB2 15292266 1303137 Taken together these results demonstrate that S1P activates multiple signaling pathways in SMC and regulates proliferation by dependent *activation* of [Elk-1] and differentiation by RhoA dependent activation of MRTF-A . Positive_regulation KCNH4 EPHB2 16440309 1554568 The inhibitor ( PD98059 ) *blocked* [Elk-1] phosphorylation , as well as COL1 and OPN gene expression . Positive_regulation KCNH4 EPHB2 17082637 1643369 inhibition not only *blocked* phosphorylation of [Elk1] , CREB , and ATF1 , which constitutively bind to the FRA-1 promoter , but also suppressed the recruitment of c-Jun to the promoter . Positive_regulation KCNH4 EPHB2 17341847 1720196 Overexpression of Rap1 and B-Raf activated MAPK extracellular dependent kinase (ERK) ERK-2 and *dependent* transcription factor [Elk-1] in neuroendocrine cell lines Bon and INS-1 . Positive_regulation KCNH4 EPHB2 17950909 1820040 Furthermore , ERK2 induced PARP-1 activation dramatically amplifies ERK-signals , enhancing *induced* phosphorylation of the transcription factor [Elk1] and enhancing core histone acetylation and expression of the Elk1 target gene , c-fos . Positive_regulation KCNH4 EPHB2 18160653 1838618 In this study we show that the excitatory neurotransmitter , glutamate , induces an *dependent* [Elk-1] activation and nuclear relocalization . Positive_regulation KCNH4 EPHB2 19218240 2054351 The Ras binding domain fused with a CD8alpha-Igalpha chimeric receptor could *induce* prolonged phosphorylation , transcriptional activation of [Elk1] , as well as the capping of the receptor in BLNK-deficient B cells . Positive_regulation KCNH4 EPHB2 21642427 2454978 Although [ELK-1] was *activated* by , JNK , and p38 MAPK in response to NaASO ( 2 ) , ELK-1 mediated activation of the p21 promoter was largely dependent on ERK . Positive_regulation KCNH4 EPHB2 21791614 2472563 Interference of p300 dependent acetylation of ATF5 or nucleosomal histone H3 or blockade of *dependent* [Elk-1] phosphorylation abrogates ATF5 dependent Egr-1 activation and cell proliferation and survival . Positive_regulation KCNH4 EPHB2 9111305 425571 The , JNK , and p38 groups of mitogen activated protein ( MAP ) kinases phosphorylate and *activate* [Elk-1] in response to a variety of extracellular stimuli . Positive_regulation KCNH4 MAP2K6 10722731 677242 Additionally , expression of N17Ras , but not L61S186Ras , a GTP bound interfering mutant , inhibited *induced* [Elk-1] phosphorylation , suggesting that inhibition of Elk-1 may be unique to GDP bound Ras mutants . Positive_regulation KCNH4 SLC38A3 9950815 595755 *induced* the transcriptional activity of both [Elk-1] and Sap-1a , transcription factors that bind to the E26 transformation specific (Ets) DNA sequence of the SRE , and this effect was inhibited by both GF-109203X and PD-98059 . Positive_regulation KCNH4 TNF 17082637 1643376 Our findings collectively indicate that ERK signaling plays key roles in both [Elk1] , CREB , and ATF-1 activation and the subsequent recruitment of c-Jun to the FRA-1 promoter in *response* to in pulmonary epithelial cells . Positive_regulation KCNH4 TNF 24121020 2867899 In addition , in vivo intestinal perfusion studies also indicated that the induced increase in mouse intestinal permeability *requires* ERK1/2 dependent activation of [Elk-1] . Positive_regulation KCNH4 TNF 24441870 2922995 Finally , we showed that *stimulated* [Elk-1] phosphorylation , which was reduced by LY294002 or PD98059 . Positive_regulation KCNH8 EPHB2 17000106 1640866 Of the 13 compounds tested , 4 compounds strongly inhibited *mediated* phosphorylation of ribosomal S6 kinase-1 (Rsk-1) and/or the transcription factor [Elk-1] and inhibited the proliferation of HeLa cervical carcinoma cells with IC ( 50 ) values in the 2-10 microM range . Positive_regulation KCNH8 EPHB2 19798549 2195756 Further , inhibitor *inhibited* significantly OPN expression , [Elk1] phosphorylation , and activator protein-1 (AP-1)-DNA binding activation , but not FAK phosphorylation , in the force applied cells . Positive_regulation KCNH8 EPHB2 24164897 2889694 The decrease of active in the nucleus *inhibited* the activation of [Elk1] , c-fos , and Fra1 , the ERK nuclear targets , leading to decreased proliferation of HCC1806 cells . Positive_regulation KCNH8 MAP2K6 19835659 2154935 To further investigate the regulation of ERK1/2 signalling , we examined the expression and activation of MEKs , the interaction of MEK with ERKs , mediated *activation* of ERK1/2 , and ERK1/2 mediated activation of nuclear substrate [Elk-1] in the prefrontal cortex and hippocampus of suicide subjects . Positive_regulation KCNK3 DCTN3 19657056 2143646 We also found that is *required* for the NOX4 dependent [TASK-1] regulation . Positive_regulation KCNK3 GABBR1 12949228 1164123 Thus mediated *activation* of [TASK-1] or a related channel provides a presynaptic autoregulatory feedback mechanism that modulates fast synaptic transmission in the rat carotid body . Positive_regulation KCNK3 GABBR1 14637154 1171379 activation *augments* [TASK-1] in MAH cells and mediates autoreceptor feedback during hypoxia . Positive_regulation KCNK3 GABBR2 12949228 1164124 Thus mediated *activation* of [TASK-1] or a related channel provides a presynaptic autoregulatory feedback mechanism that modulates fast synaptic transmission in the rat carotid body . Positive_regulation KCNK3 GABBR2 14637154 1171380 activation *augments* [TASK-1] in MAH cells and mediates autoreceptor feedback during hypoxia . Positive_regulation KCNK3 KCNK5 16718510 1777516 In all experiments , [Task 1] *required* spatially compatible manual responses ( left or right ) to the direction of an arrow , and required saying the name of the auditory letter A or B . Positive_regulation KCNK3 NOX4 19657056 2143647 We also found that p22 is required for the *dependent* [TASK-1] regulation . Positive_regulation KCNK3 PIP 15677683 1382260 Our results demonstrate that all four 2-P channels tested , [TASK1] , TASK3 , TREK1 and TRAAK are *activated* by . Positive_regulation KCNK3 PRKACB 16574908 1550021 This is mediated via *dependent* phosphorylation of [TASK-1] . Positive_regulation KCNK3 PRKACG 16574908 1550022 This is mediated via *dependent* phosphorylation of [TASK-1] . Positive_regulation KCNK3 PRKAR1A 16574908 1550023 This is mediated via *dependent* phosphorylation of [TASK-1] . Positive_regulation KCNK3 PRKAR1B 16574908 1550024 This is mediated via *dependent* phosphorylation of [TASK-1] . Positive_regulation KCNK3 PRKAR2A 16574908 1550025 This is mediated via *dependent* phosphorylation of [TASK-1] . Positive_regulation KCNK3 PRKAR2B 16574908 1550026 This is mediated via *dependent* phosphorylation of [TASK-1] . Positive_regulation KCNK5 KCNK3 16718510 1777517 In all experiments , *required* spatially compatible manual responses ( left or right ) to the direction of an arrow , and [Task 2] required saying the name of the auditory letter A or B . Positive_regulation KCNMA1 FBXO32 22586590 2614344 Reactive oxygen species signaling facilitates *dependent* vascular [BK channel] ß1 subunit degradation in diabetic mice . Positive_regulation KCNQ1 KCNE1 16631607 1556870 These results suggest that KCNE2 can functionally couple to [KCNQ1] even in the *presence* of . Positive_regulation KCNQ1 KCNE1 17161791 1661913 The purpose of this study was to study whether KCNE2 can associate with [KCNQ1] in the *presence* of and modulate its function . Positive_regulation KCNQ1 KCNE1 17161791 1661916 Coimmunoprecipitation suggests that KCNQ1 , KCNE1 , and KCNE2 can form a tripartite complex , indicating that KCNE2 can bind to [KCNQ1] in the *presence* of . Positive_regulation KCNQ1 KCNE1 21576273 2454034 Previous work on the kidney of KCNE1 and KCNQ1 knockout mice has revealed that these animals have different renal phenotypes , suggesting that may not *regulate* [KCNQ1] in the renal system . Positive_regulation KCNQ1OT1 CDKN1C 23243085 2731794 DNA methylation and gene expression analyses showed that the deletion led to an imprinting alteration restricted to the centromeric domain and resulting in silencing of [KCNQ1OT1] and *activation* of and PHLDA2 . Positive_regulation KCTD10 TNF 15982757 1428463 Like PDIP1 , the expression of [KCTD10] gene can be *induced* by in NIH3T3 cells . Positive_regulation KDR ANGPT1 16107612 1448415 These phenotypes depend strongly on p110gamma rather than on p85alpha and were associated with decreased expression of , VCAM-1 , connexin 40 , and ephrinB2 but *increased* expression of Ang-2 , VEGF-A , VEGFR1 , and [VEGFR2] . Positive_regulation KDR EPHB2 12029087 968124 Endostatin blocked VEGF induced tyrosine phosphorylation of [KDR/Flk-1] and *activation* of , p38 MAPK , and p125(FAK) in human umbilical vein endothelial cells . Positive_regulation KDR EPHB2 15541367 1336926 [VEGF-KDR] stimulation did not *induce* phosphorylation in human PKCdelta-knockdown HEK293T cells , but co-expression of rat PKCdelta-GFP recovered the ERK phosphorylation . Positive_regulation KDR EPHB2 16699073 1612193 Our results suggest that VEGF promotes cardiomyocyte differentiation predominantly by mediated [Flk-1] *activation* and , to a lesser extent , by Flt-1 activation . Positive_regulation KDR EPHB2 17644065 1775721 Endostar suppressed the VEGF induced tyrosine phosphorylation of KDR/Flk-1 ( VEGFR-2 ) as well as the overall [VEGFR-2] expression and the *activation* of , p38 MAPK , and AKT in HUVECs . Positive_regulation KDR IL1B 15081307 1234107 We have reported that *upregulates* cardiac expression of vascular endothelial growth factor ( VEGF ) and [VEGF receptor-2 (VEGFR-2)] , raising the possibility that IL-1 beta plays an important role in VEGF mediated neovascularization . Positive_regulation KDR MMP28 22402362 2582135 The mechanisms of cerebral vascular dysfunction and neuroinflammation by *mediated* degradation of [VEGFR-2] in alcohol ingestion . Positive_regulation KDR MMP28 23583373 2783516 Early [VEGFR2] activation in response to flow is VEGF dependent and *mediated* by activity . Positive_regulation KDR MMP28 23583373 2783540 Finally , we show that flow induced [VEGFR2] activation is attenuated in the *presence* of the broad spectrum inhibitor , GM6001 . Positive_regulation KDR MMP7 22402362 2582150 The mechanisms of cerebral vascular dysfunction and neuroinflammation by *mediated* degradation of [VEGFR-2] in alcohol ingestion . Positive_regulation KDR MMP7 23583373 2783531 Early [VEGFR2] activation in response to flow is VEGF dependent and *mediated* by activity . Positive_regulation KDR MMP7 23583373 2783555 Finally , we show that flow induced [VEGFR2] activation is attenuated in the *presence* of the broad spectrum inhibitor , GM6001 . Positive_regulation KDR PECAM1 24625025 2925473 Bevacizumab treatment *induced* significant low expression of mouse Pecam1/Cd31 , Eng/Cd105 , Flt1/Vegfr1 and [Kdr/Vefr2] while the human and VEGFA were upregulated . Positive_regulation KDR RCAN1 20625401 2291757 Our data suggests that RCAN1 .4 expression is induced by [VEGFR-2] activation in a Ca ( 2+ ) and PKC-delta dependent manner and that .4 *acts* to regulate calcineurin activity and gene expression facilitating endothelial cell migration and tubular morphogenesis . Positive_regulation KDR TNF 14532277 1174865 In *response* to , Etk and [VEGFR2] form a complex resulting in a reciprocal activation between the two kinases . Positive_regulation KDR TNF 14532277 1174895 Furthermore , but not VEGF *induced* activation of [VEGFR2] , Akt , and EC migration are blunted in EC genetically deficient with Etk . Positive_regulation KDR TNF 22492973 2613130 In early CL cells , *increased* angiogenic activity ( bovine aortic endothelial cell viability ) and VEGF and [VEGFR2] mRNA levels and decreased CD36 ( real-time PCR relative quantification ) . Positive_regulation KHDRBS1 CCND1 9013542 411639 Transfected [Sam68DeltaKH] inhibits serum *induced* DNA synthesis and expression . Positive_regulation KHDRBS1 TF 2557924 123300 *induced* an increase in [p68] phosphorylation . Positive_regulation KHSRP EPHB2 24026251 2846117 These results suggest that Sp1 mediated [p75NTR] expression is *regulated* at least in part by and CK2 pathways . Positive_regulation KHSRP MAP2K6 11211234 763824 Phosphorylation of [p75NTR] by p38beta2 was *induced* in vitro and in vivo by activation . Positive_regulation KHSRP NGFR 9713922 527622 and ( 3 ) [p75] mediated *induction* of apoptosis . Positive_regulation KHSRP TNF 1688503 126609 Granulocyte colony stimulating factor ( G-CSF ) , granulocyte-macrophage colony stimulating factor ( GM-CSF ) , gamma-interferon ( gamma-IFN ) , or *triggered* the rapid , stable [phosphorylation of a 75-Kd protein (p75)] when incubated with permeabilized HL60 human myeloid leukemia cells in the presence of [ gamma-32P ] ATP . Positive_regulation KHSRP TNF 23861542 2817184 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for [p75-specific] activation of NF-?B and MAPK signaling . Positive_regulation KIAA0226 TLR7 22423966 2572971 Autophagy protein [Rubicon] mediates phagocytic NADPH oxidase activation in *response* to microbial infection or stimulation . Positive_regulation KIDINS220 CAPN8 20943655 2353676 These results provide an explanation for a role for the ARMS/Kidins220 protein in synaptic plasticity events and suggest that the levels of [ARMS/Kidins220] can be *regulated* by neuronal activity and action to influence synaptic function . Positive_regulation KIF18A STK39 18083840 1837227 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation KIF2A STK39 18083840 1837302 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation KIF2B STK39 18083840 1837242 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation KIF2C STK39 18083840 1837317 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation KIRREL2 TNF 21980157 2585040 *increased* nephrin and [Neph3] mRNA expression and this effect was mediated by NF-?B . Positive_regulation KIT ANO1 23576565 2799909 Here , we report that loss of DOG1 expression occurs together with loss of KIT expression in a subset of GIST resistant to KIT inhibitors , and we illustrate the functional *role* of in tumor growth , [KIT] expression , and imatinib response . Positive_regulation KIT TNF 2156927 129520 As shown by Scatchard analysis , the *induced* increase of [ 3H ] [PBt2] binding reflected increments of phorbol ester binding site numbers rather than greater binding affinities . Positive_regulation KITLG IL1B 14563684 1175774 Transcription of [stem cell factor (SCF)] is *potentiated* by glucocorticoids and through concerted regulation of a GRE-like and an NF-kappaB response element . Positive_regulation KITLG IL1B 7691319 228851 *induced* a significant increase of soluble [SCF] from both normal and DBA BMEF . Positive_regulation KLF11 EPHB2 15300592 1283730 *induced* [KLF11] phosphorylation was examined in vitro and in vivo , and its impact on KLF11-mSin3A mediated Smad7 repression was verified in pancreatic cancer cells using site directed mutagenesis . Positive_regulation KLF2 ANGPT1 19106103 2036467 *induces* [Kruppel-like factor 2] expression through a phosphoinositide 3-kinase/AKT dependent activation of myocyte enhancer factor 2 . Positive_regulation KLF2 ANGPT1 19106103 2036474 Here , we investigated the mechanism of how signal *induces* [KLF2] expression to clarify the role of KLF2 in Ang1/Tie2 signal mediated vascular quiescence . Positive_regulation KLF2 ANGPT1 19106103 2036477 Depletion of MEF2 by siRNAs abolished Ang1 induced KLF2 expression , indicating the requirement of MEF2 in [KLF2] *induction* by . Positive_regulation KLF2 ANGPT1 19106103 2036482 Consistently , inhibition of either PI3K or AKT and depletion of AKT abrogated *induced* [KLF2] expression . Positive_regulation KLF2 ANGPT1 19106103 2036483 In addition , we confirmed the dispensability of extracellular signal regulated kinase 5 ( ERK5 ) for *induced* [KLF2] expression . Positive_regulation KLF2 FOXO1 19136962 2025521 Finally , growth factor withdrawal induced a *dependent* increase in Sell , [Klf2] and Il7r expression . Positive_regulation KLF4 TNF 23860374 2844339 *increased* expression of [KLF4] , a known regulator of SMC differentiation . Positive_regulation KLF5 CCND1 20037604 2192551 [KLF5] is a downstream signal of the ERK 1/2 and p38 MAPK pathways , and *activates* the transcription of gene via functional interaction with c-Jun in Ang II-induced VSMC proliferation . Positive_regulation KLF5 EPHB2 19411256 2089716 Finally , the *activation* of by [KLF5] is very likely through the KLF5 direct target gene FGF-BP in breast cells . Positive_regulation KLF5 EPHB2 19628677 2157584 These results suggest that Ang II induces [KLF5] phosphorylation *mediated* by the signalling in VSMCs , which in turn stimulates the interaction of KLF5 with c-Jun , subsequently leads to the suppression of p21 expression . Positive_regulation KLF5 MAP2K6 17430902 1742586 LPA mediated [KLF5] induction was partially *blocked* by inhibition of the and protein kinase C-delta . Positive_regulation KLF5 TNF 16904982 1601530 Stimulation of VSMC with Ang II and *led* to a rapid upregulation of [KLF5] expression , and a later increase in SVV , which was cell-cycle independent . Positive_regulation KLF9 LBH 22144178 2548615 Instead , [KLF9] levels correlated with bortezomib dependent inhibition of histone deacetylases (HDAC) and were *increased* by the HDAC inhibitor ( panobinostat ) . Positive_regulation KLF9 NR2F1 24349493 2881281 Based on this , we performed chromatin-immunoprecipitation followed by qRT-PCR and confirmed that directly binds and *regulates* both miR-140 and [Klf9] in vivo . Positive_regulation KLF9 PDCD5 24173774 2885809 We confirmed that overexpression *stimulated* the promoter activities of [KLF9] by luciferase reporter assays . Positive_regulation KLF9 TET1 24737412 2936308 *inducible* [KLF9] expression was established for the evaluation of the effects of KLF9 on cell proliferation , apoptosis , and xenograft tumor growth in nude mice . Positive_regulation KLF9 TET2 24737412 2936306 *inducible* [KLF9] expression was established for the evaluation of the effects of KLF9 on cell proliferation , apoptosis , and xenograft tumor growth in nude mice . Positive_regulation KLF9 TET3 24737412 2936307 *inducible* [KLF9] expression was established for the evaluation of the effects of KLF9 on cell proliferation , apoptosis , and xenograft tumor growth in nude mice . Positive_regulation KLK3 EPHB2 16282370 1525966 Stress kinase inhibition of PSA transcription is , therefore , dependent on the AR. Similar experiments involving either activation or inhibition of MAPK/ERK kinase : signaling *had* little effect on Ser 650 phosphorylation or [PSA] mRNA levels . Positive_regulation KLK3 MAP2K6 12569372 1057325 The elevation of secreted [PSA] level by the forced expression of ErbB-2 was *inhibited* by an inhibitor , PD98059 . Positive_regulation KLK3 TNF 10953159 724414 *inhibited* the ability of 10-9 M dihydrotestosterone ( DHT ) to induce LNCaP cell proliferation and activation of the [prostate specific antigen (PSA)] gene promoter . Positive_regulation KLK6 PLAU 18697857 1979639 [Pro-KLK6] and 14 can be *activated* by both plasmin and , with plasmin being the best activator of pro-KLK6 identified to date . Positive_regulation KLKB1 ARSA 6418649 33436 However , only and meclofenamate *increased* the [free-plasma kallikrein] levels despite the fact the three COIs used reduced the high molecular weight kininogen . Positive_regulation KLKB1 NR2F1 21266512 2392725 Thyroid hormone and *regulate* [kallikrein binding protein (KBP)] gene expression . Positive_regulation KLKB1 PLAT 10922430 717894 ( 65 +/- 5 U/L ) and alteplase ( 72 +/- 8 U/L ) *caused* significantly elevated [kallikrein] activity at 3 hours after adminstration ( p < 0.01 vs controls 30 +/- 1 U/L ) . Positive_regulation KLKB1 PLAT 3908315 54384 Neither [plasma kallikrein] nor the labile , human extrinsic *induced* activation . Positive_regulation KLKB1 TNF 17015177 1629421 [Kallikrein] *increased* tubular necrosis and inflammatory cell infiltration with generation of more and monocyte chemoattractant protein-1 . Positive_regulation KLRB1 IL1B 20543587 2271740 Human Th17 cells express [CD161] and exclusively originate from CD161 precursors present in umbilical cord blood and newborn thymus in *response* to the combined activity of and IL-23 . Positive_regulation KLRB1 RORC 19449310 2090758 Expression of *induced* production of IL-17A , IL-22 , IL-6 and TNF-alpha , a Th17-cell associated chemokine receptor profile and upregulation of [CD161] . Positive_regulation KLRB1 RORC 20486123 2315530 [CD161] is a marker of all human IL-17 producing T-cell subsets and is *induced* by . Positive_regulation KLRC1 CD14 19200602 2049768 Moreover , ( + ) monocytes *promote* [NKG2D] ( + ) CD4 ( + ) T cells activation through the NKG2D-MIC engagement in the pathogenesis of SLE . Positive_regulation KLRC1 TLR7 17878262 1802310 *Induction* of [NKG2D] ligands on human dendritic cells by ligand stimulation and RNA virus infection . Positive_regulation KLRC1 TNF 18360276 1887781 *Induction* of [NKG2D] ligands by gamma radiation and may participate in the tissue damage during acute graft-versus-host disease . Positive_regulation KMT2A ALOX5 25402609 2960354 Surprisingly , a constitutive *activation* of by [MLL-AF4] was inhibited by class I HDAC inhibitors , by relieving inhibitory functions deriving from MLL . Positive_regulation KMT2A MGAM 24389101 2906825 MM-401 is able to specifically *inhibit* [MLL1] activity by blocking interaction and thus the complex assembly . Positive_regulation KMT2A TNF 16386180 1494194 Cytokines are the direct mediators for multiple organ failure (MOF) , and [MOF] is *triggered* by and a cascade of cytokine release , with a prolonged high-expression of IL-6 . Positive_regulation KMT2D TNF 16386180 1494195 Cytokines are the direct mediators for multiple organ failure (MOF) , and [MOF] is *triggered* by and a cascade of cytokine release , with a prolonged high-expression of IL-6 . Positive_regulation KNG1 EPHB2 16598774 1598236 However , pagetic stromal cells stimulated with [KNG] in the *presence* of activation inhibitor peptide did not significantly affect the levels of phospho-HSP27 . Positive_regulation KNG1 EPHB2 16598774 1598237 [KNG] in the *presence* of an inhibitor peptide did not stimulate pagetic marrow stromal cell proliferation . Positive_regulation KNTC1 ELOVL4 22199362 2617282 Conditional knock-out mice were also found to have abnormal accumulation of lipid droplets and lipofuscin-like granules while demonstrating photoreceptor-specific abnormalities in visual response , indicating the critical *role* of for proper [rod] or cone photoreceptor function . Positive_regulation KRAS AGR2 8021500 263075 These events may be important for *activation* of [Ras] by the . Positive_regulation KRAS ANGPT1 12039842 954275 Accordingly , ephrinB2 inhibited VEGF- and *induced* [Ras-MAPK] activities , whereas ephrinB2 did not alter VEGF induced Flk phosphorylation or Ang1 induced Tie2 phosphorylation . Positive_regulation KRAS CCND1 11223027 787811 Thus , [Ras] activity during G2 phase *induces* expression . Positive_regulation KRAS CCND1 12429909 1015096 These studies were designed to understand how [Ras] could *induce* levels only during G2 phase . Positive_regulation KRAS CTGF 15855807 1425609 TGF-beta1 induced connective tissue growth factor ( ) expression in human renal proximal tubule epithelial cells *requires* [Ras/MEK/ERK] and Smad signalling . Positive_regulation KRAS EDN2 17707940 1800760 Endothelin stimulated protein kinase C ( PKC ) was partially inhibited by both YM-254890 and pertussis toxin , while only pertussis toxin attenuated *induced* [Ras] activation . Positive_regulation KRAS EPHB2 10898494 712066 Here , we analyzed the effects of Vav on three known downstream targets of [Ras] , i. e. *activation* of and NFAT , and up-regulation of the activation antigen CD69 . Positive_regulation KRAS EPHB2 10978313 751957 Whereas the essential *roles* of and JNK in [Ras] signaling has been established , the contribution of p38 remains unclear . Positive_regulation KRAS EPHB2 11018025 752781 Expression of a dominant negative mutant of Ras also did not significantly impair calcium induced ERK activation , indicating that calcium mediated activation does not *require* active [Ras] . Positive_regulation KRAS EPHB2 11088001 764965 We show that the activation of via SSTR1 is mediated by the betagamma subunit of a pertussis toxin-sensitive G-protein and *requires* both the small G protein [Ras] and the serine/threonine kinase Raf-1 . Positive_regulation KRAS EPHB2 11574537 882427 NT-stimulated activity *requires* [Ras] activation because overexpression of the dominant negative Ras mutant Ras-17N almost completely inhibits the Erk activation . Positive_regulation KRAS EPHB2 12364324 1019151 GLP1 stimulated activation of is blocked by inhibitors of MEK , but GLP1 does not *induce* the activation of A-Raf , B-Raf , C-Raf , or [Ras] . Positive_regulation KRAS EPHB2 12902401 1121124 LPA induced chemotaxis is markedly dependent on activation of PTX-sensitive heterotrimeric G-proteins , on *activation* of the small GTPases [Ras] , Rac and RhoA , and on GTPase dependent activation of . Positive_regulation KRAS EPHB2 15205467 1281173 Thus , unlike galectin-1 , which prolongs [Ras] *activation* of and inhibits PI3-K , K-Ras-GTP/galectin-3 interactions promote , in addition to PI3-K and Raf-1 activation , a third inhibitory signal that attenuates active ERK . Positive_regulation KRAS EPHB2 15650750 1364059 Influx of calcium , mediated either by L-type voltage-sensitive calcium channels or glutamate receptors , is associated with the suppression of brain derived neurotrophic factor (BDNF) *activation* of [Ras] and its effectors and Akt . Positive_regulation KRAS EPHB2 16436505 1540515 In addition , we demonstrated that Tat activation of [Ras] , but not of Rac , *induces* phosphorylation . Positive_regulation KRAS EPHB2 20176802 2222130 [Ras] *activation* of restores impaired tonic BCR signaling and rescues immature B cell differentiation . Positive_regulation KRAS EPHB2 20639215 2322044 We found that phosphorylation of this receptor contributed to [Ras] and ERK activation and that inhibition of , PKC , and EGFR *blocked* the mitogenic response induced by sPLA ( 2 ) -IIA . Positive_regulation KRAS EPHB2 21330403 2420301 Measurements of the dephosphorylation of and the *activation* of [Ras] showed that the ROS scavenger prevents the cAMP provoked activation of Ras and that cAMP , with or without a ROS scavenger , has little or no effect on the dephosphorylation of ERK . Positive_regulation KRAS EPHB2 21771815 2456803 [Ras] continues to promote subsequent aspects of duct morphogenesis and differentiation , and *acts* primarily through and the transcriptional effectors LIN-1/Ets and EOR-1 . Positive_regulation KRAS EPHB2 21949793 2488025 Like costimulation via CD28 , active [Ras] *induced* AKT , JNK and phosphorylation . Positive_regulation KRAS EPHB2 22258408 2544913 We observed that loss of mitochondrial genome reversibly *induced* overexpression and activation of proto-oncogenic [Ras] , especially K-Ras 4A , responsible for the activation of AKT and leading to advanced phenotype of prostate and breast cancer . Positive_regulation KRAS EPHB2 22687285 2643697 *activation* of [RAS] signaling to LKB1 and RASGRP3 , via and p90RSK , might be involved in liver carcinogenesis and be used as a prognostic marker . Positive_regulation KRAS EPHB2 22871572 2671699 [KRAS] ( G12D ) - and BRAF ( V600E ) -induced transformation of murine pancreatic epithelial cells *requires* stimulated IGF1R signaling . Positive_regulation KRAS EPHB2 9234703 445395 [Ras] *activation* of was inhibited by both Pak1 ( R299 ) and Pak1 ( L83,L86,R299 ) , while neither mutant inhibited Raf activation of ERK . Positive_regulation KRAS EPHB2 9556628 499867 A dominant negative form of RHAMMv4 inhibits mutant active [Ras] *activation* of and coimmunoprecipitates with both mitogen activated protein kinase kinase and ERK , suggesting that the intracellular RHAMMv4 acts downstream of Ras , possibly at the level of mitogen activated protein kinase kinase-ERK interactions . Positive_regulation KRAS EPHB2 9892010 586566 We show that the activation of via SSTR1 is pertussis toxin sensitive and *requires* the small G protein [Ras] , phosphatidylinositol 3-kinase , the serine/threonine kinase Raf-1 , and the protein tyrosine phosphatase SHP-2 . Positive_regulation KRAS FAS 9240472 445944 Osmotic cell shrinkage did not interfere with *induced* activation of the acidic sphingomyelinase or activation of [Ras] but impaired the formation of O2 suggesting an important function of cell volume in the synthesis of reactive oxygen intermediates upon Fas receptor ligation . Positive_regulation KRAS FHL1 23456229 2781812 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Positive_regulation KRAS GPR115 9020193 412936 A scaffold for mediated [Ras] *activation* . Positive_regulation KRAS GPR132 9020193 412925 A scaffold for mediated [Ras] *activation* . Positive_regulation KRAS GPR87 9020193 413005 A scaffold for mediated [Ras] *activation* . Positive_regulation KRAS ITGB2 17624948 1770114 We have recently shown that Ras is also downstream of LFA-1 engagement : signaling through phospholipase D (PLD) to RasGRP1 was *required* for [Ras] activation on the plasma membrane following stimulation of TCR . Positive_regulation KRAS MAP2K6 10442634 635724 Finally , while Rlf-CAAX does not increase Erk activity , inhibition of *blocks* both [Ras-] as well as Rlf-CAAX induced differentiation , suggesting that RalGEFs induce PrE differentiation in a manner depending on basal MEK or Erk activity . Positive_regulation KRAS MAP2K6 10978313 751987 was *required* for [Ras] stimulation of the p38 pathway . Positive_regulation KRAS MAP2K6 12411397 1010762 PE and ET-1 do not activate protein kinase B but stimulate [Ras] and Erk , and their ability to activate protein synthesis was *blocked* by inhibition of Ras or and by rapamycin , which inhibits mTOR ( mammalian target of rapamycin ) . Positive_regulation KRAS MAP2K6 19022560 2029204 Furthermore , *activation* of Raf-1 , and the ERKs by either EGF or [Ras] ( G12R ) was inhibited by NM23H2 overexpression . Positive_regulation KRAS MAP2K6 22871572 2671706 [KRAS] ( G12D ) - and BRAF ( V600E ) -induced transformation of murine pancreatic epithelial cells *requires* stimulated IGF1R signaling . Positive_regulation KRAS MAP2K6 23546290 2763056 Second , farnesyltransferase inhibitor I , a [Ras] *inhibitor* , and U0126 , a inhibitor , induced an inhibition of the cell proliferation in C6 cells , while the cell proliferation was inhibited by nobiletin as well . Positive_regulation KRAS MAP2K6 8182145 256492 One of these pathways involves the activation of [Ras] , leading to the activation of Raf-1 , and the subsequent *activation* of ( MAPK or ERK kinase ) . Positive_regulation KRAS MAP2K6 9135066 427698 Moreover , inhibition of endogenous by a specific inhibitor , PD 098059 , *suppressed* the activation of p96h2bk by oncogenic [Ras] . Positive_regulation KRAS NGFR 8108130 246106 We have previously shown that nerve growth factor (NGF) induces a rapid and relatively continuous activation of Ras in rat pheochromocytoma PC12 cells while epidermal growth factor (EGF) activates Ras transiently , and that tyrosine kinase activity of the is *essential* for the activation of [Ras] ( Muroya et al. , Oncogene , 7 , 277-281 , 1992 ) . Positive_regulation KRAS S100B 21209080 2391859 The *dependent* activation of diaphanous-1/Rac1/JNK/AP-1 , Ras/Rac1/NF-?B and [Src/Ras/PI3K/RhoA/diaphanous-1] results in the up-regulation of expression of the chemokines , CCL3 , CCL5 , and CXCL12 , whose release and activity are required for S100B to stimulate microglia migration . Positive_regulation KRAS SELL 8986819 404098 Stimulation of the Ras pathway by L-selectin requires functional p56lck , since p56lck-deficient Jurkat cells ( JCaM1.6 ) do not show tyrosine phosphorylation , association of with Grb2/Sos , and *activation* of [Ras] upon L-selectin triggering . Positive_regulation KRAS TNF 12600818 1085043 treatment *induced* both [Ras] and MEKK1 activation . Positive_regulation KRAS TNF 14999690 1216809 In conclusion , these data support the hypotheses that hepatocellular oxidative stress leads to cell death and that *induced* [Ras] activation is important in hepatic proliferation in response to ethanol induced liver injury . Positive_regulation KRAS TNF 17059425 1683926 Zoledronate reduced Ras prenylation , [Ras] and RhoA translocation to the membrane , and sustained ERK1/2 phosphorylation and *induced* JNK phosphorylation . Positive_regulation KRAS TNF 17994109 1851157 triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* [Ras] , p38 MAPK , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation KRAS TNF 18310456 1879062 Simvastatin potently suppressed TNF-alpha induced phosphorylation of ERK1/2 and SAPK/JNK by inhibiting *induced* membrane localization of [Ras] and RhoA . Positive_regulation KRAS TNF 21938476 2532760 With 4-MC pretreatment to hyperglycemic rats the following results were noted : ( i ) Decrease in pancreatic NGF level was blocked , ( ii ) Increase in pancreatic TNF-a level and the number of ( + ) beta cell in the islets were prevented , ( iii ) *Increase* in the number of ß cell synthhesized apoptotic [Ras] effectors that RASSF1 and NORE1 was blocked , ( iv ) While pancreatic lipid peroxidation level decreased , antioxidant molecule glutathione and antioxidant enzymes glutathione peroxidase , catalase and superoxide dismutase activities increased , ( v ) Pancreatic caspase-3 activity and the number of cleaved caspase-3 ( + ) ß cells were decreased . Positive_regulation KRR1 EPHB2 16948396 1610026 Neither JNK nor inhibition *had* a significant effect on cytokine mediated inhibition of [RIP1] activity . Positive_regulation KRR1 TNF 17389591 1735590 Our results demonstrate that RIP1 mediated AIP1 phosphorylation at the 14-3-3 binding site Ser-604 is essential for *induced* [TRAF2-RIP1-AIP1-ASK1] complex formation and for the activation of ASK1-JNK/p38 apoptotic signaling . Positive_regulation KRR1 TNF 18621737 1954359 Therefore , c-IAP1 and c-IAP2 are required for *stimulated* [RIP1] ubiquitination and NF-kappaB activation . Positive_regulation KRR1 TNF 19131965 2042494 RNF11 negatively regulated [RIP1] and TRAF6 ubiquitination upon *stimulation* with and LPS , respectively . Positive_regulation KRR1 TNF 21746883 2471980 FADD was found to mediate formation of the *induced* pronecrotic [RIP1-RIP3] kinase complex , whereas the I?B Kinase ( IKK ) subunit NEMO appears to function downstream of RIP1-RIP3 . Positive_regulation KRR1 TNF 23307752 2786371 Although the increased [RIP1] activity *induced* by a activates mitogen activated protein kinases ( MAPKs ) including ERK and leads to apoptotic or necrotic cell death , it is unclear what is the role of ERK during the process of necroptosis . Positive_regulation KRR1 TNF 24113711 2852672 We show that Pellino3 targets RIP1 , in a TNF dependent manner , to inhibit *induced* complex II formation and caspase 8-mediated cleavage of [RIP1] in response to TNF/cycloheximide co-stimulation . Positive_regulation KRR1 TNF 24735611 2939066 Interestingly , brazilin did not affect the *induced* [RIP1] ubiquitination and the recruitment of RIP1 and TRAF2 to TNFR1 , suggesting that brazilin is effective in selectively suppressing the proximal signaling complex formation of IL-1R , but not that of TNFR1 . Positive_regulation KRT1 ID1 20887552 2326836 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT1 PCSK9 17554144 1778561 In a reconstituted epidermis model , K6PC-4 , K6PC-5 , and significantly *increased* [keratin 1] expression in the suprabasal layer . Positive_regulation KRT10 FLG 7679679 211293 Sr2+ in 0.05 mM Ca2+ medium *induces* the expression of the differentiation-specific keratins , keratin 1 (K1) , [keratin 10 (K10)] , and the granular cell marker , , as determined by both immunoblotting and immunofluorescence . Positive_regulation KRT10 ID1 20887552 2326816 Specific NF-?B inhibitors ( pyrrolidine dithiocarbamate , PDTC ) , or dominant negative inhibitor ( I kappa B alpha mutant , I?BaM ) abrogated the *induced* cell proliferation and [keratin 10] production whereas p65 , a subunit of the NF-?B heterodimer and an enhancer of the NF-?B activity , strengthened the Id1 induced cell proliferation and keratin 10 production . Positive_regulation KRT10 ID1 20887552 2326837 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT12 ID1 20887552 2326838 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT13 ID1 20887552 2326839 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT14 ID1 20887552 2326840 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT14 TNF 9060638 417778 We now report that induces translocation of cPLA2 from the cytosol to membranes in Ad-infected human A549 cells and that [E3-10.4K/14.5K] but not E3-14.7K or E1B-19K is *required* to inhibit TNF induced translocation of cPLA2 . Positive_regulation KRT15 ID1 20887552 2326841 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT16 ID1 20887552 2326842 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT17 ID1 20887552 2326843 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT18 ID1 20887552 2326844 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT19 ID1 20887552 2326845 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT19 MAP2K6 15793288 1386978 [CK19] expression and branching morphogenesis were *inhibited* by dexamethasone , a 1 ( MEK1 ) inhibitor ( PD98059 ) , and a phosphatidyl inositol 3-kinase inhibitor ( LY294002 ) . Positive_regulation KRT2 ID1 20887552 2326847 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT20 ID1 20887552 2326819 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT222 ID1 20887552 2326824 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT23 ID1 20887552 2326846 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT24 ID1 20887552 2326817 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT25 ID1 20887552 2326831 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT26 ID1 20887552 2326832 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT27 ID1 20887552 2326833 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT28 ID1 20887552 2326834 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT3 ID1 20887552 2326848 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT3 JAG1 17652726 1776212 In contrast , activation *resulted* in decreased [CK3] expression ( P < 0.05 ) , though neither Notch activation nor inhibition affected cell proliferation in the 3D tissue equivalent . Positive_regulation KRT31 ID1 20887552 2326854 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT32 ID1 20887552 2326855 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT34 ID1 20887552 2326856 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT35 ID1 20887552 2326857 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT36 ID1 20887552 2326858 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT37 ID1 20887552 2326859 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT38 AP2A1 7517240 243511 Thus , the *role* of in [keratin] gene expression is quantitative rather than qualitative . Positive_regulation KRT38 AP2M1 7517240 243512 Thus , the *role* of in [keratin] gene expression is quantitative rather than qualitative . Positive_regulation KRT38 BMP4 20607477 479008 In addition , inhibits retinoic acid (RA) induced neural differentiation of P19 cells and *induces* [keratin] expression . Positive_regulation KRT38 CD44 16255911 1477465 The expressions of vimentin and [keratin] were respectively *detected* with immunocytochemistry , while the expressions of CD8 , CD34 , , vascular cell adhesion molecule-1 ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ) were determined by flow cytometry . Positive_regulation KRT38 CD8A 16255911 1477466 The expressions of vimentin and [keratin] were respectively *detected* with immunocytochemistry , while the expressions of , CD34 , CD44 , vascular cell adhesion molecule-1 ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ) were determined by flow cytometry . Positive_regulation KRT38 CD8B 16255911 1477467 The expressions of vimentin and [keratin] were respectively *detected* with immunocytochemistry , while the expressions of , CD34 , CD44 , vascular cell adhesion molecule-1 ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ) were determined by flow cytometry . Positive_regulation KRT38 CISH 8996639 404346 Moreover , an inhibitor of the collagen synthesis , , *suppressed* the [keratin] synthesis but had no effect on the pHi recovery . Positive_regulation KRT38 CRK 17535969 1751641 To demonstrate that *dependent* [keratin] phosphorylation determines keratin organization , p38 activity was pharmacologically and genetically modulated : up-regulation induced keratin granule formation , whereas down-regulation prevented keratin filament network disassembly . Positive_regulation KRT38 CRK 17535969 1751691 Furthermore , transient inhibition also *inhibited* [keratin] filament precursor formation and mutant keratin granule dissolution . Positive_regulation KRT38 EGF 2444479 78515 *stimulated* degradation of glucocorticoid induced [alpha-keratin] . Positive_regulation KRT38 EGF 2578529 45302 *stimulates* tyrosine phosphorylation of pig epidermal fibrous [keratin] . Positive_regulation KRT38 EGF 2578529 45352 The analysis of phosphorylated phosphoamino acids revealed that *stimulated* tyrosine phosphorylation of pig epidermal fibrous [keratin] . Positive_regulation KRT38 EGF 6190952 28249 *stimulates* phosphorylation of pig epidermal [keratin] protein . Positive_regulation KRT38 EGF 6190952 28299 *stimulated* phosphorylation of [keratin] proteins ( Mr : 65,000 , 60,000 , 56,000 , and 51,000 ) identified by the Ouchterlony immunodiffusion analysis , a low Mr protein ( 16,000 dalton ) of the urea-SDS-mercaptoethanol soluble fraction , and a 30,000 dalton Tris-HCl soluble protein . Positive_regulation KRT38 EGF 6190952 28352 Anti-EGF serum eliminated the *stimulated* phosphorylation of [keratin] proteins , a low Mr protein , and a 30,000 dalton Tris-HCl soluble protein . Positive_regulation KRT38 EGF 7537080 300625 We have recently shown that and transforming growth factor beta ( TGF beta ) , modulators of keratinocyte proliferation , *regulate* expression of specific [keratin] genes . Positive_regulation KRT38 EGF 8612697 353379 Specifically , while *induces* expression of K6 and K16 [keratin] genes , retinoic acid suppresses their expression , and when both mediators are present simultaneously , the level of expression is intermediate , a product of both signals . Positive_regulation KRT38 FOXN1 10767081 684740 Forkhead/winged-helix transcription factor *regulates* hair [keratin] gene expression : molecular analysis of the nude skin phenotype . Positive_regulation KRT38 FOXN1 11054532 745654 Among other functions , ( formerly known as Whn ) *regulates* the expression of hair [keratin] genes in the hair follicle , which represents an evolutionarily novel organ characteristic of mammals . Positive_regulation KRT38 FOXN1 17938256 1866450 however , how *regulates* hair [keratin] expression and hair formation is largely unknown . Positive_regulation KRT38 HOXC13 16292560 1510713 We previously showed that the homeodomain protein is *involved* in the expression control of the early human hair [keratin] genes hHa5 and hHa2 , which contain specific HOXC13 binding sites in their proximal promoters . Positive_regulation KRT38 HOXC13 22583695 2686754 Among these , is also *involved* in the expression control of the human [keratin] genes hHa5 and hHa2 , and recently it was identified as a member of human DNA replication complexes . Positive_regulation KRT38 ICAM1 16255911 1477468 The expressions of vimentin and [keratin] were respectively *detected* with immunocytochemistry , while the expressions of CD8 , CD34 , CD44 , vascular cell adhesion molecule-1 ( VCAM-1 ) and ( ICAM-1 ) were determined by flow cytometry . Positive_regulation KRT38 ID1 20887552 2326860 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT38 IFNG 1372562 183111 *regulates* expression of a novel [keratin] class I gene . Positive_regulation KRT38 IFNG 3122220 81699 Immunohistochemical staining of these `` tumoroids '' with a differentiation specific , anti-keratin antibody indicated that *enhanced* expression of this [keratin] . Positive_regulation KRT38 IL6 17213200 1702727 *induces* [keratin] expression in intestinal epithelial cells : potential role of keratin-8 in interleukin-6 induced barrier function alterations . Positive_regulation KRT38 JUN 10825196 696369 We conclude that GR suppresses keratin gene expression through two independent mechanisms : directly , through interactions of keratin nGREs with four GR monomers , as well as indirectly , by blocking the *induction* of [keratin] gene expression . Positive_regulation KRT38 KRT10 18219278 1919054 In addition , the unaffected , heterozygous carriers of the mutation indicate that the peptide from one normal allele alone is *sufficient* for [keratin] network formation . Positive_regulation KRT38 KRT6A 17914454 1858529 As predicted for a dominant negative disease , simultaneous expression of both wild-type and mutant *resulted* in defective [keratin] filament formation . Positive_regulation KRT38 MAPK3 16630075 1552018 We have previously demonstrated that mechanical stretching induced proliferative phenotypes in human keratinocytes , as shown in increased 5-bromo-2'-deoxyuridine ( BrdU ) incorporation , activation , and [keratin] K6 *induction* . Positive_regulation KRT38 MYLIP 20522784 2320024 Microarray , qRT-PCR and Western blot analyses revealed that negatively *regulates* expression of Fgf10 , the components of Wnt and BMP signaling pathways Sclerostin and BAMBI , and Dlx3 transcription factor , as well as selected [keratin] genes , both in vitro and in vivo . Positive_regulation KRT38 MYO10 17011064 1641353 In particular , the reduced fluorescent coenzyme NAD ( P ) H , flavoproteins , [keratin] , melanin , and elastin are *detected* by two-photon excited autofluorescence , whereas , tubulin and the ECM protein collagen can be imaged additionally by second harmonic generation ( SHG ) . Positive_regulation KRT38 MYO16 17011064 1641352 In particular , the reduced fluorescent coenzyme NAD ( P ) H , flavoproteins , [keratin] , melanin , and elastin are *detected* by two-photon excited autofluorescence , whereas , tubulin and the ECM protein collagen can be imaged additionally by second harmonic generation ( SHG ) . Positive_regulation KRT38 MYO19 17011064 1641351 In particular , the reduced fluorescent coenzyme NAD ( P ) H , flavoproteins , [keratin] , melanin , and elastin are *detected* by two-photon excited autofluorescence , whereas , tubulin and the ECM protein collagen can be imaged additionally by second harmonic generation ( SHG ) . Positive_regulation KRT38 MYO6 17011064 1641354 In particular , the reduced fluorescent coenzyme NAD ( P ) H , flavoproteins , [keratin] , melanin , and elastin are *detected* by two-photon excited autofluorescence , whereas , tubulin and the ECM protein collagen can be imaged additionally by second harmonic generation ( SHG ) . Positive_regulation KRT38 OCLN 15157238 1250554 IOSE-Ov29 resembled OVCAR3 and differed from IOSE-29 as shown by its unlimited life span , tumorigenicity , epithelial morphology , [keratin] , , E-cadherin and CA125 expression , *increased* expression of kinases of the PI3K pathway , and loss of cGMP dependent protein kinase expression . Positive_regulation KRT38 PTHLH 8170470 255178 inhibition in HPK1A-AS cells *resulted* in reduced high mol wt [keratin] production , as assessed by immunocytochemistry . Positive_regulation KRT38 SFTPC 22344252 2606126 We establish that the MEK-ERK signaling cascade regulates both *induced* [keratin] phosphorylation and reorganization in human pancreatic and gastric cancer cells and identify Ser431 in keratin 8 as the crucial residue whose phosphorylation is required and sufficient to induce keratin reorganization and consequently enhanced migration of human epithelial tumor cells . Positive_regulation KRT38 SOX2 16079156 1442648 Conversely , misexpression of Xfoxi1a suppresses and *induces* [keratin] in the anterior neural plate . Positive_regulation KRT38 TFAP2A 1722450 173400 This paper identifies a new , developmental *role* for transcription factor in the activation of amphibian embryonic epidermal [keratin] gene expression . Positive_regulation KRT38 TFAP2A 1722450 173550 Thus , the study of and its *role* in the regulation of [keratin] gene transcription should enhance our understanding of both amphibian embryonic development and mammalian skin differentiation . Positive_regulation KRT38 TGFB1 7537080 300622 We have recently shown that epidermal growth factor (EGF) and ( TGF beta ) , modulators of keratinocyte proliferation , *regulate* expression of specific [keratin] genes . Positive_regulation KRT38 TGFB2 7537080 300623 We have recently shown that epidermal growth factor (EGF) and ( TGF beta ) , modulators of keratinocyte proliferation , *regulate* expression of specific [keratin] genes . Positive_regulation KRT38 TGFB3 7537080 300624 We have recently shown that epidermal growth factor (EGF) and ( TGF beta ) , modulators of keratinocyte proliferation , *regulate* expression of specific [keratin] genes . Positive_regulation KRT38 TLR3 23233254 2731706 The lead siRNA , with an IC ( 50 ) of thirty picomolar , showed no [keratin] off-target effects or *activation* of in the concentration ranges tested . Positive_regulation KRT38 TRH 23373458 2803657 Preliminary evidence had suggested that may *regulate* [keratin] gene transcription . Positive_regulation KRT38 VCAM1 16255911 1477464 The expressions of vimentin and [keratin] were respectively *detected* with immunocytochemistry , while the expressions of CD8 , CD34 , CD44 , ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ) were determined by flow cytometry . Positive_regulation KRT39 ID1 20887552 2326835 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT4 ID1 20887552 2326849 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT40 ID1 20887552 2326822 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT5 ID1 20887552 2326850 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT6B TNF 10887174 736712 Specifically , *induces* the transcription of the [K6b] gene promoter . Positive_regulation KRT6B TNF 10887174 736713 Both transcription factors are necessary for the *induction* of [K6b] by and act as a complex , although only C/EBPbeta binds the K6b promoter DNA . Positive_regulation KRT7 ID1 20887552 2326851 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT7 RARB 9287985 452416 Furthermore , overexpression *resulted* in induction of cellular differentiation in xenografted tumors as evidenced by increased tumor cell expression of duct cell differentiation markers carcinoembryonic antigen (CEA) , CA19-9 , and [cytokeratin 7] . Positive_regulation KRT71 ID1 20887552 2326826 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT72 ID1 20887552 2326830 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT73 ID1 20887552 2326827 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT74 ID1 20887552 2326828 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT75 ID1 20887552 2326821 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT76 ID1 20887552 2326820 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT77 ID1 20887552 2326818 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT78 ID1 20887552 2326825 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT79 ID1 20887552 2326829 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT8 EPHB2 15763073 1383344 Requirement for activation in acetone extract identified from Bupleurum scorzonerifolium *induced* A549 tumor cell apoptosis and [keratin 8] phosphorylation . Positive_regulation KRT8 ID1 20887552 2326852 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT80 ID1 20887552 2326823 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT81 ID1 20887552 2326861 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT82 ID1 20887552 2326862 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT83 ID1 20887552 2326863 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT84 ID1 20887552 2326864 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT85 ID1 20887552 2326865 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT86 ID1 20887552 2326866 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KRT9 ID1 20887552 2326853 contributed to hyperproliferation of keratinocytes via enhancement of cell cycle progression , removal of cell cycle inhibition , and simultaneously *increased* [keratin] production . Positive_regulation KSR1 TNF 11221891 787473 Furthermore , *induced* Raf-1 threonine phosphorylation , kinase activity toward MEK1 , and association with [KSR] are also inhibited by kiKSR expression . Positive_regulation KSR1 TNF 11221891 787475 Our data also show by sequential in vitro kinase assays that *enhances* [KSR] phosphorylation of Raf-1 on threonine , enhancing Raf-1 kinase activity toward MAP kinase kinase . Positive_regulation LACRT TGM2 23425695 2760027 Exogenous *initiated* [lacritin] cross linking within 1 minute and was complete by 90 minutes-even with as little as 0.1 nM lacritin , and involved the donors lysine 82 and 85 and the acceptor glutamine 106 in the syndecan-1 binding domain . Positive_regulation LACRT TGM2 23769845 2870599 Levels of active monomeric [lacritin] are negatively *regulated* by tear , whose expression is elevated in dry eye with ocular surface inflammation . Positive_regulation LAMA1 IL1B 18434122 1926374 or TNF-alpha alone *induced* increased secretion of type IV collagen , [laminin-1] , and nidogen-1/entactin , all of which contributed to this upregulation . Positive_regulation LAMA1 TNF 18434122 1926373 IL-1beta or alone *induced* increased secretion of type IV collagen , [laminin-1] , and nidogen-1/entactin , all of which contributed to this upregulation . Positive_regulation LAMA3 TNF 15541073 1336871 Although interleukin-1alpha had no effect , transforming growth factor (TGF)-alpha , and TGF-beta1 also *stimulated* [laminin 5] synthesis , and TGF-alpha and TGF-beta1 showed a synergistic effect . Positive_regulation LAMA3 TNF 9366409 463240 TNF-alpha induced hepatocyte spreading was blocked by cytochalasin D , Arg-Gly-Asp peptides , cycloheximide , or anti-integrin beta1 Ab. Results of competitive PCR for ECM proteins demonstrated that *increased* the expression of [laminin alpha3] and gamma1 chains in hepatocytes . Positive_regulation LAMA4 PRKDC 11448237 835687 We present evidence that transcription of the extracellular matrix gene [laminin alpha 4 (Lama4)] is *regulated* by in a radiation independent manner . Positive_regulation LAMA4 XRCC5 11448237 835685 We present evidence that transcription of the extracellular matrix gene [laminin alpha 4 (Lama4)] is *regulated* by in a radiation independent manner . Positive_regulation LAMA4 XRCC6 11448237 835686 We present evidence that transcription of the extracellular matrix gene [laminin alpha 4 (Lama4)] is *regulated* by in a radiation independent manner . Positive_regulation LAMA5 MMP28 12147229 969877 The cell migration promoting activity of [laminin-10/11] was *down-regulated* by an inhibitor . Positive_regulation LAMA5 MMP7 12147229 969892 The cell migration promoting activity of [laminin-10/11] was *down-regulated* by an inhibitor . Positive_regulation LAMA5 PLAU 10791952 714406 Bead immobilized [laminin-5] and collagen I , two major alpha ( 3 ) beta ( 1 ) ligands , also *induced* expression . Positive_regulation LAMA5 TNF 15087281 1279333 However , in combination , and IFN-gamma synergistically *stimulated* the secretion of both [laminin-5] and -10 in HIEC cells . Positive_regulation LAMB1 EPHB2 18701453 1979673 Incubation with selective kinase inhibitors showed that high glucose- and high insulin induced [laminin beta1] synthesis and phosphorylation of GSK3beta were *dependent* on PI 3-kinase , , and mTOR . Positive_regulation LAMB1 IL1B 18434122 1926376 or TNF-alpha alone *induced* increased secretion of type IV collagen , [laminin-1] , and nidogen-1/entactin , all of which contributed to this upregulation . Positive_regulation LAMB1 MMP28 12147229 969899 The cell migration promoting activity of [laminin-10/11] was *down-regulated* by an inhibitor . Positive_regulation LAMB1 MMP7 12147229 969914 The cell migration promoting activity of [laminin-10/11] was *down-regulated* by an inhibitor . Positive_regulation LAMB1 TNF 15087281 1279335 However , in combination , and IFN-gamma synergistically *stimulated* the secretion of both [laminin-5 and -10] in HIEC cells . Positive_regulation LAMB1 TNF 18434122 1926375 IL-1beta or alone *induced* increased secretion of type IV collagen , [laminin-1] , and nidogen-1/entactin , all of which contributed to this upregulation . Positive_regulation LAMB2 MMP28 12147229 969921 The cell migration promoting activity of [laminin-10/11] was *down-regulated* by an inhibitor . Positive_regulation LAMB2 MMP7 12147229 969936 The cell migration promoting activity of [laminin-10/11] was *down-regulated* by an inhibitor . Positive_regulation LAMB2 PLAU 10791952 714407 Bead immobilized [laminin-5] and collagen I , two major alpha ( 3 ) beta ( 1 ) ligands , also *induced* expression . Positive_regulation LAMB2 TNF 15087281 1279337 However , in combination , and IFN-gamma synergistically *stimulated* the secretion of both [laminin-5] and -10 in HIEC cells . Positive_regulation LAMB3 AKT1 22673183 2669811 [Laminin-332] upregulation was also observed in CAFs and NBFs , but at a lower level than in InFs . Laminin-332 *induced* ( Ser473 ) phosphorylation by binding to integrin a3ß1 . Positive_regulation LAMB3 AKT2 22673183 2669812 Laminin-332 upregulation was also observed in CAFs and NBFs , but at a lower level than in InFs . [Laminin-332] *induced* ( Ser473 ) phosphorylation by binding to integrin a3ß1 . Positive_regulation LAMB3 AKT3 22673183 2669813 [Laminin-332] upregulation was also observed in CAFs and NBFs , but at a lower level than in InFs . Laminin-332 *induced* ( Ser473 ) phosphorylation by binding to integrin a3ß1 . Positive_regulation LAMB3 BSG 18243135 1871450 In contrast , type IV collagen and [laminin-332] did not *induce* . Positive_regulation LAMB3 EGF 15541073 1336862 Among growth factors , , insulin-like growth factor-1 , interferon-gamma and keratinocyte growth factor *increased* [laminin 5] production in keratinocytes , while platelet derived growth factor , hepatocyte growth factor and basic fibroblast growth factor were ineffective . Positive_regulation LAMB3 ETS1 15846078 1439536 Together with previous studies showing that laminin-5 is involved in the invasive and malignant phenotype of several tumor types , our data suggest that the oncogenic effect of may be *mediated* in part by upregulation of [LAMB3] expression . Positive_regulation LAMB3 ETS2 15846078 1439537 Together with previous studies showing that laminin-5 is involved in the invasive and malignant phenotype of several tumor types , our data suggest that the oncogenic effect of may be *mediated* in part by upregulation of [LAMB3] expression . Positive_regulation LAMB3 FGF2 16996573 1674006 Down-regulation of during transformation may *contribute* to loss of [laminin 5] expression . Positive_regulation LAMB3 FGF7 15541073 1336863 Among growth factors , epidermal growth factor , insulin-like growth factor-1 , interferon-gamma and *increased* [laminin 5] production in keratinocytes , while platelet derived growth factor , hepatocyte growth factor and basic fibroblast growth factor were ineffective . Positive_regulation LAMB3 IFNG 15541073 1336864 Among growth factors , epidermal growth factor , insulin-like growth factor-1 , and keratinocyte growth factor *increased* [laminin 5] production in keratinocytes , while platelet derived growth factor , hepatocyte growth factor and basic fibroblast growth factor were ineffective . Positive_regulation LAMB3 IGF1 15541073 1336865 Among growth factors , epidermal growth factor , , interferon-gamma and keratinocyte growth factor *increased* [laminin 5] production in keratinocytes , while platelet derived growth factor , hepatocyte growth factor and basic fibroblast growth factor were ineffective . Positive_regulation LAMB3 LGALS1 24503541 2914131 decreased the expression of collagen genes COL3A1 (COL-3) and COL5A1 (COL-5) but *increased* the expression of fibronectin (FN) and [laminin 5 (LM-5)] , that were reversed by ß-lactose . Positive_regulation LAMB3 MYLIP 23159910 2707549 Furthermore , we focused on LAMB3 which has a miR-218 target site and gene expression studies and luciferase reporter assays showed that [LAMB3] was directly *regulated* by . Positive_regulation LAMB3 TCF12 18713836 1955575 HIF1 *regulates* [laminin-332] expression and keratinocyte migration . Positive_regulation LAMB3 TCF15 18713836 1955576 HIF1 *regulates* [laminin-332] expression and keratinocyte migration . Positive_regulation LAMB3 TCF19 18713836 1955577 HIF1 *regulates* [laminin-332] expression and keratinocyte migration . Positive_regulation LAMB3 TCF20 18713836 1955578 HIF1 *regulates* [laminin-332] expression and keratinocyte migration . Positive_regulation LAMB3 TCF21 18713836 1955579 HIF1 *regulates* [laminin-332] expression and keratinocyte migration . Positive_regulation LAMB3 TCF23 18713836 1955583 HIF1 *regulates* [laminin-332] expression and keratinocyte migration . Positive_regulation LAMB3 TCF24 18713836 1955585 HIF1 *regulates* [laminin-332] expression and keratinocyte migration . Positive_regulation LAMB3 TCF25 18713836 1955584 HIF1 *regulates* [laminin-332] expression and keratinocyte migration . Positive_regulation LAMB3 TCF3 18713836 1955580 HIF1 *regulates* [laminin-332] expression and keratinocyte migration . Positive_regulation LAMB3 TCF4 18713836 1955581 HIF1 *regulates* [laminin-332] expression and keratinocyte migration . Positive_regulation LAMB3 TCF7 18713836 1955582 HIF1 *regulates* [laminin-332] expression and keratinocyte migration . Positive_regulation LAMB3 TGFB1 15541073 1336872 Although interleukin-1alpha had no effect , transforming growth factor (TGF)-alpha , tumour necrosis factor (TNF)-alpha and also *stimulated* [laminin 5] synthesis , and TGF-alpha and TGF-beta1 showed a synergistic effect . Positive_regulation LAMB3 TGFB1 15541073 1336877 In line with the increase of laminin 5 synthesis , the expression levels of all three [laminin 5] genes were also *augmented* by TGF-alpha and . Positive_regulation LAMB3 TGFB1 20844080 2336812 Autocrine activation mediated by integrin {alpha}V{beta}3 *regulates* transcriptional expression of [laminin-332] in Madin-Darby canine kidney epithelial cells . Positive_regulation LAMB3 TGFB1 7635220 317072 ( TGF-beta ) *enhanced* LAMA3 , [LAMB3] , and LAMC2 gene expression in human epidermal keratinocytes , as well as in HaCaT and Balb/K cells in culture , although the extent of enhancement was greater for LAMA3 and LAMC2 genes than for LAMB3 . Positive_regulation LAMB3 TGFB2 7635220 317073 ( TGF-beta ) *enhanced* LAMA3 , [LAMB3] , and LAMC2 gene expression in human epidermal keratinocytes , as well as in HaCaT and Balb/K cells in culture , although the extent of enhancement was greater for LAMA3 and LAMC2 genes than for LAMB3 . Positive_regulation LAMB3 TGFB3 7635220 317074 ( TGF-beta ) *enhanced* LAMA3 , [LAMB3] , and LAMC2 gene expression in human epidermal keratinocytes , as well as in HaCaT and Balb/K cells in culture , although the extent of enhancement was greater for LAMA3 and LAMC2 genes than for LAMB3 . Positive_regulation LAMB3 TNF 15541073 1336873 Although interleukin-1alpha had no effect , transforming growth factor (TGF)-alpha , and TGF-beta1 also *stimulated* [laminin 5] synthesis , and TGF-alpha and TGF-beta1 showed a synergistic effect . Positive_regulation LAMB3 ZEB1 20729552 2335772 coordinately *regulates* [laminin-332] and { beta } 4 integrin expression altering the invasive phenotype of prostate cancer cells . Positive_regulation LAMC1 IL1B 18434122 1926378 or TNF-alpha alone *induced* increased secretion of type IV collagen , [laminin-1] , and nidogen-1/entactin , all of which contributed to this upregulation . Positive_regulation LAMC1 IL1B 7864166 296330 *increases* [laminin B2 chain] mRNA levels and activates NF-kappa B in rat glomerular epithelial cells . Positive_regulation LAMC1 KLF9 12034813 949027 Synergistic *activation* of the rat [laminin gamma1] chain promoter by the gut enriched ( GKLF/KLF4 ) and Sp1 . Positive_regulation LAMC1 MMP28 12147229 969943 The cell migration promoting activity of [laminin-10/11] was *down-regulated* by an inhibitor . Positive_regulation LAMC1 MMP7 12147229 969958 The cell migration promoting activity of [laminin-10/11] was *down-regulated* by an inhibitor . Positive_regulation LAMC1 TNF 15087281 1279339 However , in combination , and IFN-gamma synergistically *stimulated* the secretion of both [laminin-5 and -10] in HIEC cells . Positive_regulation LAMC1 TNF 18434122 1926377 IL-1beta or alone *induced* increased secretion of type IV collagen , [laminin-1] , and nidogen-1/entactin , all of which contributed to this upregulation . Positive_regulation LAMC2 TNF 15541073 1336875 Although interleukin-1alpha had no effect , transforming growth factor (TGF)-alpha , and TGF-beta1 also *stimulated* [laminin 5] synthesis , and TGF-alpha and TGF-beta1 showed a synergistic effect . Positive_regulation LAMC2 TNF 20307265 2238077 Loss of Smad4 may lead to uncoupled induction of [laminin-gamma2] in *response* to and may therefore represent one of the mechanisms which underlie accumulation of laminin-gamma2 at the invasive margin of a tumor . Positive_regulation LAMC3 PLAU 10791952 714408 Bead immobilized [laminin-5] and collagen I , two major alpha ( 3 ) beta ( 1 ) ligands , also *induced* expression . Positive_regulation LAMC3 TNF 15087281 1279341 However , in combination , and IFN-gamma synergistically *stimulated* the secretion of both [laminin-5] and -10 in HIEC cells . Positive_regulation LAMTOR5 CCND1 21239735 2379828 We also showed that [HBXIP] *induced* cellular accumulation in the S phase concomitantly with up-regulation of and down-regulation of p21 and p53 levels . Positive_regulation LANCL1 IL1B 15730393 1377494 However , , but not IFN-gamma , *induced* IL-12 [p40] production by DCs without enhancing phenotypic maturation . Positive_regulation LANCL1 IL1B 16307851 1526151 PGE ( 2 ) is synergistic with and TNF-alpha in the induction of functional and phenotypic maturation of DC and *induce* IL12 [p40] production . Positive_regulation LANCL1 TLR7 17897860 1811302 Thus TLR3 and *contribute* to TMEV induced IL-23 p19 and [p40] , while TLR3 contributes to TMEV induced IFN-beta . Positive_regulation LANCL1 TLR7 21190998 2391288 In the present study , we show for the first time that IL-29 can increase *induced* [IL-12p40] production by human monocyte derived macrophages . Positive_regulation LANCL1 TLR7 23750720 2834120 In contrast to humans , pDC in rhesus macaques expressed the interleukin [(IL)-12p40] subunit in *response* to as well as TLR-9 stimulation . Positive_regulation LANCL1 TNF 12207325 983558 We observed that ATPgammaS potentiated the [IL-12p40] release *induced* by , but also by lipopolysaccharides (LPS) and soluble CD40 ligand ( sCD40L ) . Positive_regulation LANCL1 TNF 12871593 1114124 Interestingly , we have found that IL-12 p70 , p402 ( the p40 homodimer ) and [p40] ( the p40 monomer ) dose-dependently *induced* the production of and the expression of TNF-alpha mRNA in BV-2 microglial cells . Positive_regulation LANCL1 TNF 16307851 1526150 PGE ( 2 ) is synergistic with IL-1beta and in the induction of functional and phenotypic maturation of DC and *induce* IL12 [p40] production . Positive_regulation LANCL1 TNF 19607809 2123914 Both OA-NO ( 2 ) and LNO ( 2 ) prevented *stimulated* release of the cytokines , IL-6 , IL-8 , [IL-12/p40] , IFNgamma , MCP-1 , and IP-10 , and inhibited NF-kappaB activation . Positive_regulation LAT EFNB1 15502157 1347553 Further downstream of the signaling pathway , stimulation *led* to increased [LAT] ( linker for activation of T-cells ) phosphorylation and p44/42 and p38 MAPK activation . Positive_regulation LAT EPHB2 17119112 1700613 Although RhoH is not required for TCR induced activation of ZAP70 and ZAP70 mediated activation of p38 , it is crucial for the tyrosine phosphorylation of [LAT] , PLCgamma1 , and Vav1 and for the *activation* of and calcium influx . Positive_regulation LAT EPHB2 19717519 2133535 TCR activation in double positive cells with stabilized beta-catenin triggered signaling associated with negative selection , including sustained overactivation of [Lat] and Jnk and a transient *activation* of . Positive_regulation LAT FAS 23240581 2745580 Consistent with that hypothesis , we show that induction of phosphorylation by pervanadate or H2O2 in Jurkat cells and thymocytes inhibits *mediated* cleavage of [LAT] . Positive_regulation LAT MAP2K6 10779414 687425 The TCR induced increase in [LAT] expression *involved* the activation of the serine/threonine kinases PKC and , because inhibitors of these kinases blocked the increase in LAT . Positive_regulation LAT STK39 8892860 392181 We found that activation of the LAT promoter requires Ras activation and that activation of the , Raf , is *sufficient* to induce [LAT] expression . Positive_regulation LBH KLF9 22144178 2548616 Instead , levels correlated with bortezomib dependent inhibition of histone deacetylases (HDAC) and were *increased* by the HDAC inhibitor [LBH589] ( panobinostat ) . Positive_regulation LBH SMN2 19584083 2129348 [LBH589] *induces* up to 10-fold protein levels by several independent mechanisms and is effective even in cells from SMA patients non-responsive to valproate . Positive_regulation LBH SMN2 19584083 2129382 Notably , [LBH589] also *induces* expression in SMA fibroblasts inert to VPA , in human neural stem cells and in the spinal cord of SMN2-transgenic mice . Positive_regulation LBP ALB 12372833 1019649 Incubation of LOS ( agg ) with LBP and sCD14 promoted LOS ( agg ) disaggregation in an *dependent* fashion to complexes that contain LOS and sCD14 , but no [LBP] , with an apparent M ( r ) approximately 60,000 ( LOS : sCD14 ) as determined by Sephacryl S200 chromatography . Positive_regulation LBP CD14 12117913 964646 [Lipopolysaccharide binding protein-] and dependent *activation* of mitogen activated protein kinase p38 by lipopolysaccharide in human neutrophils is associated with priming of respiratory burst . Positive_regulation LBP CD14 7528733 291385 The human whole-blood system was used as an in vitro model of [lipopolysaccharide (LPS) binding protein] and dependent *activation* of cytokine production . Positive_regulation LBP CPB1 9118690 423665 Also , *induced* a gradual increase of the acute-phase reactant [LBP] , which was identical in the noncoated and heparin coated groups . Positive_regulation LBP CPB2 9118690 423666 Also , induced a gradual *increase* of the acute-phase reactant [LBP] , which was identical in the noncoated and heparin coated groups . Positive_regulation LBP CSF3 23437199 2744544 The *induced* [LBP] upregulation caused LPS hypersensitization in rats as indicated by higher mortality and severer liver damage . Positive_regulation LBP CSRP1 22475270 2643114 SOCS-3 , CRP , and [LBP] were extensively *induced* by IL-6 , with maximal induction observed at 2 ( SOCS-3 ) and 12 hrs ( ; Positive_regulation LBP HMOX1 24400114 2900313 The inhibitor , ZnPP , *diminished* the [LBP] treatment induced protective effects in the retina after I/R. Taken together , these results suggested that LBP partially exerted its beneficial neuroprotective effects via the activation of Nrf2 and an increase in HO-1 protein expression . Positive_regulation LBP IL1A 10919979 717297 These cells produced [LBP] in *response* to , IL-6 , and tumor necrosis factor- alpha , a response that was strongly enhanced by dexamethasone . Positive_regulation LBP IL1A 7510687 249934 To examine this phenomenon in more detail , we evaluated the capacity of IL-6 , , and tumor necrosis factor to *induce* [LBP] synthesis in HepG2 cells in the presence or absence of dexamethasone . Positive_regulation LBP IL1A 7790054 313177 In contrast to IL-6 and LPS , in the presence of 10 ( -6 ) M dexamethasone , and tumor necrosis factor (TNF) *led* to maximal [LBP] mRNA induction levels , 4.7- and 3.8-fold , respectively , suggesting that IL-6 and LPS stimulate LBP expression by mechanisms different from those of IL-1 and TNF . Positive_regulation LBP IL1B 15114678 1241426 We show here that TGF-beta 1 , in a dose dependent fashion , is able to inhibit LBP transcript accumulation and [LBP] protein synthesis *induced* by IL-6 , and dexamethasone in hepatoma cell lines . Positive_regulation LBP IL1B 19010986 2029053 IL-6 , and cigarette smoke condensate *induced* the expression of [LBP] and CD14 by airway epithelial cells . Positive_regulation LBP IL1B 7695925 297283 *Induction* of [lipopolysaccharide binding protein] gene expression in cultured rat pulmonary artery smooth muscle cells by . Positive_regulation LBP IL1B 7695925 297284 Of this mixture , alone was *sufficient* to induce [LBP] mRNA expression in both a time- and dose dependent manner . Positive_regulation LBP IL1B 8668165 369364 We show that induction of [LBP] expression is transcriptionally regulated and is *dependent* on stimulation with , IL-6 , and dexamethasone . Positive_regulation LBP IL22 17442982 1729798 *induces* [lipopolysaccharide binding protein] in hepatocytes : a potential systemic role of IL-22 in Crohn 's disease . Positive_regulation LBP IL22 17442982 1729799 also *enhanced* the secretion of [LBP] in human primary hepatocytes and HepG2 hepatoma cells in vitro . Positive_regulation LBP IL6 10919979 717298 These cells produced [LBP] in *response* to interleukin (IL)-1beta , , and tumor necrosis factor- alpha , a response that was strongly enhanced by dexamethasone . Positive_regulation LBP IL6 22475270 2643115 SOCS-3 , CRP , and [LBP] were extensively *induced* by , with maximal induction observed at 2 ( SOCS-3 ) and 12 hrs ( CRP ; Positive_regulation LBP IL6 7510687 249935 To examine this phenomenon in more detail , we evaluated the capacity of , IL-1 , and tumor necrosis factor to *induce* [LBP] synthesis in HepG2 cells in the presence or absence of dexamethasone . Positive_regulation LBP IL6 7510687 249936 *induced* [LBP] synthesis . Positive_regulation LBP IL6 7790054 313175 The *induction* of [LBP] by or LPS was attenuated by dexamethasone . Positive_regulation LBP IL6 7790054 313178 In contrast to IL-6 and LPS , in the presence of 10 ( -6 ) M dexamethasone , IL-1 and tumor necrosis factor (TNF) led to maximal LBP mRNA induction levels , 4.7- and 3.8-fold , respectively , suggesting that and LPS *stimulate* [LBP] expression by mechanisms different from those of IL-1 and TNF . Positive_regulation LBP IL6 8668165 369365 We show that induction of [LBP] expression is transcriptionally regulated and is *dependent* on stimulation with IL-1beta , , and dexamethasone . Positive_regulation LBP MAPK1 23194012 2752019 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Positive_regulation LBP MAPK1 23194012 2752045 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Positive_regulation LBP MAPK10 23194012 2752020 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Positive_regulation LBP MAPK10 23194012 2752046 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Positive_regulation LBP MAPK11 23194012 2752021 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Positive_regulation LBP MAPK11 23194012 2752047 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Positive_regulation LBP MAPK12 23194012 2752022 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Positive_regulation LBP MAPK12 23194012 2752048 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Positive_regulation LBP MAPK13 23194012 2752023 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Positive_regulation LBP MAPK13 23194012 2752049 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Positive_regulation LBP MAPK14 23194012 2752024 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Positive_regulation LBP MAPK14 23194012 2752050 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Positive_regulation LBP MAPK15 23194012 2752018 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Positive_regulation LBP MAPK15 23194012 2752044 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Positive_regulation LBP MAPK3 23194012 2752025 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Positive_regulation LBP MAPK3 23194012 2752051 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Positive_regulation LBP MAPK4 23194012 2752026 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Positive_regulation LBP MAPK4 23194012 2752052 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Positive_regulation LBP MAPK6 23194012 2752027 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Positive_regulation LBP MAPK6 23194012 2752053 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Positive_regulation LBP MAPK7 23194012 2752028 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Positive_regulation LBP MAPK7 23194012 2752054 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Positive_regulation LBP MAPK8 23194012 2752029 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Positive_regulation LBP MAPK8 23194012 2752055 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Positive_regulation LBP MAPK9 23194012 2752030 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Positive_regulation LBP MAPK9 23194012 2752056 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Positive_regulation LBP TGFB1 15114678 1241425 Inhibition of hepatic transcriptional *induction* of [lipopolysaccharide binding protein] by . Positive_regulation LBP TLR4 10733550 678455 [LBP] plays an important role in mediating Kupffer cell activation by LPS , and these effects are *dependent* on the presence of functioning . Positive_regulation LBP TLR4 11528597 853554 [Lipopolysaccharide binding protein] *increases* activation by nontypeable Haemophilus influenzae . Positive_regulation LBP TNF 12181178 977489 With increasing concentrations of LPS , human Kupffer cell production ( a marker for Kupffer cell activation ) *increased* in a dose dependent manner in the presence and absence of [LBP] . Positive_regulation LBP TNF 7510687 249933 To examine this phenomenon in more detail , we evaluated the capacity of IL-6 , IL-1 , and to *induce* [LBP] synthesis in HepG2 cells in the presence or absence of dexamethasone . Positive_regulation LBP TNF 7790054 313176 In contrast to IL-6 and LPS , in the presence of 10 ( -6 ) M dexamethasone , IL-1 and *led* to maximal [LBP] mRNA induction levels , 4.7- and 3.8-fold , respectively , suggesting that IL-6 and LPS stimulate LBP expression by mechanisms different from those of IL-1 and TNF . Positive_regulation LCAT NPNT 23663413 2791174 APOA1 , DCN and expression was higher in cyclic compared to pregnant heifers , and pregnancy *increased* ( P < 0.05 ) the expression of [LCAT] , NCDN , NMN , PLIN2 and TINAGL1 . Positive_regulation LCAT TNF 7666003 322114 Endotoxin and *lead* to reduced plasma [LCAT] activity and decreased hepatic LCAT mRNA levels in Syrian hamsters . Positive_regulation LCK AGR2 8077654 270694 We show that cross linking the B cell with anti-Ig Abs *activates* [p56lck] ( Lck ) in both the immature B cell line WEHI-231 and mature resting B cells from mouse spleen . Positive_regulation LCK AGR2 8077654 270696 We show that the 60-kDa form of [Lck] *induced* by cross linking in B cells is also phosphorylated at serine 59 . Positive_regulation LCK AGR2 8077654 270698 Thus , in B cells , cross linking *activates* [Lck] and subsequently activates a kinase that phosphorylates Lck at serine 59 , a potential negative regulatory site . Positive_regulation LCK EPHB2 21152094 2356337 TCR stimulation led to the co-precipitation of Lck with the transmembrane adaptor protein LAT ( linker for activation of T cells ) , *mediated* phosphorylation of [Lck] and no detectable dephosphorylation of Lck inhibitory tyrosine . Positive_regulation LCK FAS 11093032 754932 Furthermore , osmotic cell shrinkage blunted the *induced* activation of the Src-like kinase [p56lck] . Positive_regulation LCK FAS 15016553 1220927 Finally , the apoptotic effect of Tip in T cells is mediated by and *requires* the presence of active [Lck] in the cell . Positive_regulation LCK ITGAL 11698443 878014 We find that conjugate formation between Jurkat T cells and EBV-B cells presenting superantigen is mediated by and absolutely *requires* [Lck] . Positive_regulation LCK PLAU 14534291 1174981 Luciferase reporter gene assay indicated that [Lck] *induces* NFkappaB dependent ( uPA ) promoter activity in presence of H/R . Positive_regulation LCK SELL 8986819 404090 In this study we show that triggering of Jurkat cells using different antibodies or glycomimetics *resulted* in activation of the src-tyrosine kinase [p56lck] ; Positive_regulation LCK SELL 8986819 404099 Stimulation of the Ras pathway by *requires* functional [p56lck] , since p56lck-deficient Jurkat cells ( JCaM1.6 ) do not show tyrosine phosphorylation , association of L-selectin with Grb2/Sos , and activation of Ras upon L-selectin triggering . Positive_regulation LCN2 EPHB2 22537847 2608299 inhibition with SL327 fully *prevented* fentanyl induced [p25] upregulation . Positive_regulation LCN2 IL1B 14662866 1177637 *induces* a > 10-fold up-regulation of [NGAL] expression in the type II pneumocyte derived cell line A549 cells , whereas TNF-alpha , IL-6 , and LPS had no effect . Positive_regulation LCN2 IL1B 16622025 1551561 Expression of [NGAL] is *up-regulated* in the lung epithelial cell line A549 by , but not by TNF-alpha , despite an induction of NF-kappaB binding to the NGAL promoter by both cytokines . Positive_regulation LCN2 IL1B 19009554 2016520 [Lipocalin-2] is *induced* by in murine adipocytes in vitro . Positive_regulation LCN2 IL1B 19009554 2016523 Experiments using pharmacological inhibitors indicated that *induced* [Lcn2] expression is mediated via nuclear factor kappaB and janus kinase 2 . Positive_regulation LCN2 IL1B 19009554 2016524 Taken together , our results show an *upregulation* of [Lcn2] by in fat cells implicating a potential role of this adipocyte secreted acute phase reactant in the development of insulin resistance , obesity , and associated disorders including cardiovascular disease . Positive_regulation LCN2 IL1B 19329498 2074149 Our main findings were ( i ) patients with acute post-myocardial infarction ( MI ) HF ( n = 236 ) and chronic HF ( n = 150 ) had elevated serum levels of NGAL ( determined by enzyme immunoassay ) , significantly correlated with clinical and neurohormonal deterioration , ( ii ) in patients with HF following acute MI , elevated NGAL levels of at baseline were associated with adverse outcomes ( median of 27 months follow-up ) , ( iii ) in a rat model of post-MI HF , NGAL/lipocalin-2 gene expression was increased in the non-ischaemic part of the left ventricle primarily located to cardiomyocytes , ( iv ) strong NGAL immunostaining was found in cardiomyocytes within the failing myocardium both in experimental and clinical HF , ( v ) and agonists for toll-like receptors 2 and 4 , representing components of the innate immune system , were potent *inducers* of [NGAL/lipocalin-2] in isolated neonatal cardiomyocytes . Positive_regulation LCN2 MAP2K6 22537847 2608305 inhibition with SL327 fully *prevented* fentanyl induced [p25] upregulation . Positive_regulation LCN2 TNF 14662866 1177636 IL-1beta *induces* a > 10-fold up-regulation of [NGAL] expression in the type II pneumocyte derived cell line A549 cells , whereas , IL-6 , and LPS had no effect . Positive_regulation LCN2 TNF 14662866 1177643 activation of NF-kappaB , in contrast , did not *increase* NGAL synthesis , even though induced binding of NF-kappaB to the [NGAL] promoter was observed in vitro . Positive_regulation LCN2 TNF 16622025 1551560 Expression of [NGAL] is *up-regulated* in the lung epithelial cell line A549 by IL-1beta , but not by , despite an induction of NF-kappaB binding to the NGAL promoter by both cytokines . Positive_regulation LCN2 TNF 20220144 2249422 We demonstrate here that [NGAL] is strongly *induced* by stimulation with in the presence of IL-17 , a pro-inflammatory cytokine produced by the newly discovered subset of CD4 ( + ) T helper cells , T ( H ) -17 . Positive_regulation LCN2 TNF 20220144 2249429 In contrast to the murine NGAL orthologue , 24p3/lipocalin 2 , we found no requirement for C/EBP-beta or C/EBP-delta for [NGAL] *induction* by IL-17 and as neither small interfering RNAs against the two C/EBP mRNAs nor mutation of the C/EBP sites in the LCN2 promoter abolished IL-17- and TNF-alpha induced up-regulation of NGAL . Positive_regulation LCN2 TNF 21403867 2361398 Both IL-1ß and *regulate* [NGAL] expression in polymorphonuclear granulocytes of chronic hemodialysis patients . Positive_regulation LCN2 TNF 21421891 2458139 IL-1ß , , and LPS *stimulated* [NGAL] in cytotrophoblast cells ( not syncytiotrophoblast and decidua ) in vitro . Positive_regulation LCP1 TNF 1966546 149783 and interleukin-1 (IL-1) *enhanced* the phosphorylation of identical cytosolic 65 kDa protein ( P65 or [l-plastin] ) and 74 kDa protein ( P74 ) at serine residues in human peripheral blood mononuclear cells ( PBMC ) . Positive_regulation LDHA TNF 10385397 625420 *stimulates* [lactate dehydrogenase A] expression in porcine cultured sertoli cells : mechanisms of action . Positive_regulation LDHA TNF 10385397 625421 Inhibitors of protein synthesis ( cycloheximide ) , gene transcription ( actinomycin D and dichlorobenzimidazole riboside ) , tyrosine kinase ( genistein ) , and protein kinase C ( bisindolylmaleimide ) abrogated completely ( actinomycin D , dichlorobenzimidazole riboside , cycloheximide , and genistein ) or partially ( bisindolylmaleimide ) *induced* [LDH A] mRNA expression . Positive_regulation LDHA TNF 14586559 1187184 In patients after administration of chemotherapy , in a dose of 100 U/ml *induced* a significant increase ( p < 0.05 ) of [LDH-M] isotype activity , but not of LDH-H . Positive_regulation LDHB TNF 14586559 1187185 In patients after administration of chemotherapy , in a dose of 100 U/ml *induced* a significant increase ( p < 0.05 ) of LDH-M isotype activity , but not of [LDH-H] . Positive_regulation LDLR EPHB2 15531889 1343183 Using human hepatoma cells , we show that BBR upregulates [LDLR] expression independent of sterol regulatory element binding proteins , but *dependent* on activation . Positive_regulation LDLR EPHB2 19007237 2006623 Collectively , these new findings identify gossypin as a new hypocholesterolemic agent that up-regulates [LDLR] expression independent of SREBP-2 but is *dependent* on activation . Positive_regulation LDLR EPHB2 19283084 2046467 however , it was unclear whether activation is *required* for [LDLR] mRNA up-regulation by A. phagocytophilum . Positive_regulation LDLR EPHB2 9392422 467753 Moreover , pretreatment of cells with calphostin C inhibited TPA mediated activation and [LDL receptor] mRNA *induction* in a dose dependent fashion . Positive_regulation LDLR IL1B 16543490 1549712 However , *enhanced* [LDL receptor] expression , overriding the suppression usually induced by a high concentration of LDL and inappropriately increasing LDL uptake . Positive_regulation LDLR IL1B 18752326 1956366 Confocal microscopy showed that *increased* the translocation of SCAP/SREBP-2 complex from endoplasmic reticulum ( ER ) to Golgi in HepG2 cells , thereby activating [LDLr] gene transcription . Positive_regulation LDLR IL1B 19180880 2007105 Rapamycin dose-dependently suppressed the increased expression of [LDLR] *induced* by and up-regulated the suppressed expression of ABCA1 caused by IL-1 beta . Positive_regulation LDLR IL1B 9469590 485912 In addition , *increased* [LDL receptor] mRNA levels as well as protein activity , although IL-6 did not , suggesting that the more marked decrease in apoB accumulation in the medium induced by IL-1beta compared with that induced by IL-6 may reflect an increased uptake of apoB from the medium by IL-1beta . Positive_regulation LDLR IL1B 9624172 511390 Northern analysis demonstrated that or TNF significantly *increased* [LDL receptor] transcript in HepG2 cells , whereas expression of another tightly regulated sterol-responsive squalene synthase gene was unaffected . Positive_regulation LDLR IL1B 9624172 511391 PD98059 , a specific inhibitor of MAPK kinase activity , inhibited *induced* [LDL receptor] expression . Positive_regulation LDLR IL1B 9624172 511393 In contrast , SB202190 , a specific inhibitor of p38 ( MAPK ) , enhanced *induced* [LDL receptor] expression , with a concomitant increase in ERK-1/2 activity . Positive_regulation LDLR IL1B 9641167 514127 TNF alpha , TGF beta , PDGF or did not significantly stimulate HMCL proliferation at the concentrations given above , but maximally *stimulated* [LDLr] mRNA expression and increased LDLr promoter activity by 167.48+/-23.56 % , 150.47+/-24.41 % , 127.71+/-24.65 % and 163.01+/-31.91 % respectively , at 24 h . Positive_regulation LDLR IL1B 9641167 514158 TNF alpha , TGF beta , PDGF and *increased* [LDLr] gene expression by increasing sterol independent and mitogenesis independent gene transcription . Positive_regulation LDLR PCSK9 15677715 1369863 Overexpression of in HepG2 cells *caused* a decrease in whole-cell and cell-surface [LDLR] levels . Positive_regulation LDLR PCSK9 15677715 1369864 overexpression had no effect on LDLR synthesis but *caused* a dramatic increase in the degradation of the mature [LDLR] and a lesser increase in the degradation of the precursor LDLR . Positive_regulation LDLR PCSK9 15677715 1369865 In contrast , overexpression of a catalytically inactive mutant *prevented* the degradation of the mature [LDLR] ; Positive_regulation LDLR PCSK9 15677715 1369866 The *induced* degradation of the [LDLR] was not affected by inhibitors of the proteasome , lysosomal cysteine proteases , aspartic acid proteases , or metalloproteases . Positive_regulation LDLR PCSK9 15677715 1369867 The *induced* degradation of the [LDLR] was shown to require transport out of the endoplasmic reticulum . Positive_regulation LDLR PCSK9 15767856 1384242 The cellular role for PCSK9 and the mechanism behind its mutations are under study , and a *role* for in regulating [LDL receptor] protein levels has been demonstrated . Positive_regulation LDLR PCSK9 15805190 1390954 Missense mutations in PCSK9 cause an autosomal dominant form of hypercholesterolemia in humans , likely due to a gain-of-function mechanism because overexpression of either WT or mutant *reduces* hepatic [LDL receptor protein (LDLR)] in mice . Positive_regulation LDLR PCSK9 17242417 1710111 Moreover , inhibition of expression *resulted* in a 2-fold increase in hepatic [LDLR] protein levels . Positive_regulation LDLR PCSK9 17328821 1706674 Also the *mediated* degradation of the [LDLR] does not take place on the cell surface . Positive_regulation LDLR PCSK9 17328821 1706675 Rather , the *mediated* degradation of the [LDLR] appears to take place intracellularly and occurs even when endocytosis through clathrin coated pits is blocked by hypertonic medium . Positive_regulation LDLR PCSK9 17449864 1760966 Secreted *mediated* cell surface [LDLR] degradation in a concentration- and time dependent manner when added to HEK293 cells . Positive_regulation LDLR PCSK9 17449864 1760970 Together , these results reveal that secreted retains biological activity , is able to bind directly to the LDLR extracellular domain , and undergoes LDLR-ARH mediated endocytosis , *leading* to accelerated intracellular degradation of the [LDLR] . Positive_regulation LDLR PCSK9 17461796 1743216 Herein , we asked whether the subcellular localization of wild-type PCSK9 or mutants of PCSK9 and the LDLR would provide insight into the mechanism of *dependent* [LDLR] degradation . Positive_regulation LDLR PCSK9 17493938 1766634 Effects of pH and low density lipoprotein (LDL) on *dependent* [LDL receptor] regulation . Positive_regulation LDLR PCSK9 18039658 1852244 The proprotein convertase *induces* the degradation of [low density lipoprotein receptor (LDLR)] and its closest family members VLDLR and ApoER2 . Positive_regulation LDLR PCSK9 18052825 1889366 Genetic and cell biology studies have suggested a critical *role* of in regulating [low-density lipoprotein receptor (LDLR)] protein levels and thus modulating plasma LDL cholesterol . Positive_regulation LDLR PCSK9 18631360 1947581 In this study , we have assembled homologs of human PCSK9 from 20 vertebrates , a cephalochordate and mollusks in order to search for conserved regions of PCSK9 that may be important for the *mediated* degradation of [LDLR] . Positive_regulation LDLR PCSK9 18638454 1947619 Thus , inflammation stimulates expression *leading* to increased [LDL receptor] degradation and decreasing LDL receptors thereby increasing serum LDL , which could have beneficial effects on host defense . Positive_regulation LDLR PCSK9 18666258 1943119 *enhances* [LDLR] degradation , resulting in low-density lipoprotein accumulation in plasma . Positive_regulation LDLR PCSK9 18675252 1955157 We show for the first time that an EGF-A peptide inhibits *mediated* degradation of [LDLR] in HepG2 cells . Positive_regulation LDLR PCSK9 18753623 1956407 Structural requirements for *mediated* degradation of the [low-density lipoprotein receptor] . Positive_regulation LDLR PCSK9 18753623 1956409 Thus , domains in both the LDLR and PCSK9 that are not required for binding ( or internalization ) are essential for *mediated* degradation of the [LDLR] . Positive_regulation LDLR PCSK9 18799458 1986857 Several gain-of-function mutations in PCSK9 cause hypercholesterolemia and premature atherosclerosis , and thus , inhibition of *induced* degradation of the [LDLR] may be used to treat this deadly disease . Positive_regulation LDLR PCSK9 19063703 2018000 mRNA silencing or inhibition of *induced* degradation of [LDLR] may be used to treat this disease . Positive_regulation LDLR PCSK9 19081568 2035891 gain-of-function mutants *enhance* [LDLR] degradation . Positive_regulation LDLR PCSK9 19489072 2102870 Interestingly , stable expression of or a more active membrane bound form of the protein ( PCSK9-ACE2 ) *resulted* in a marked reduction in CD81 and [LDLR] expression . Positive_regulation LDLR PCSK9 19635789 2143047 Dissection of the endogenous cellular pathways of *induced* [low density lipoprotein receptor] degradation : evidence for an intracellular route . Positive_regulation LDLR PCSK9 19635789 2143049 Although the mechanism by which *regulates* [LDLR] degradation is not fully resolved , it seems to involve both intracellular and extracellular pathways . Positive_regulation LDLR PCSK9 19635789 2143051 The present data from HepG2 cells and mouse primary hepatocytes favor a model whereby depending on the dose and/or incubation period , endogenous *enhances* the degradation of the [LDLR] both extra- and intracellularly . Positive_regulation LDLR PCSK9 19705336 2127196 ( proprotein convertase subtilisin/kexin type 9 ) *mediates* the post-translational degradation of the [LDL receptor (LDLR)] and , as a result , modulates serum levels of LDL-cholesterol (LDL-C) . Positive_regulation LDLR PCSK9 19705336 2127197 Similarly , mice lacking the expression of PCSK9 exhibit higher levels of LDLR in the liver and reduced serum cholesterol , while the overexpression of *reduces* [LDLR] and results in increased serum cholesterol . Positive_regulation LDLR PCSK9 19828345 2202983 Thus , the mechanism for the *mediated* degradation of the [LDLR] does not appear to involve an interaction between the endosomal sorting machinery and LDLR-specific motifs in the cytoplasmic domain . Positive_regulation LDLR PCSK9 19828345 2202984 Moreover , ubiquitination of lysines in the cytoplasmic domain does not appear to play a critical role in the *mediated* degradation of the [LDLR] . Positive_regulation LDLR PCSK9 19917273 2197783 Cell culture experiments showed that increasing concentrations of low density lipoprotein (LDL) in the media , decreased the amount of PCSK9 internalized and decreased the *mediated* degradation of the [LDLR] . Positive_regulation LDLR PCSK9 20048381 2248054 Thus , the net balance is in favor of *induced* degradation of [LDLR] in the hamster liver , abrogating the effect of rosuvastatin on LDL-C lowering . Positive_regulation LDLR PCSK9 21149300 2384734 Thus , CT domain interaction with the LBD of the LDLR at endosomal pH constitutes a second step in the *mediated* [LDLR] binding that leads to receptor degradation . Positive_regulation LDLR PCSK9 22074827 2513974 Our data suggest that the ubiquitination system is involved in *induced* [LDLR] degradation . Positive_regulation LDLR PCSK9 22108858 2541332 *increases* the degradation of the [LDL receptor] , resulting in high LDL-C in individuals with high PCSK9 activity . Positive_regulation LDLR PCSK9 22176652 2543129 released from SMCs directly *regulated* [LDLR] expression in macrophages as demonstrated by retroviral overexpression or knockdown of PCSK9 with small interfering RNA and by using recombinant PCSK9 . Positive_regulation LDLR PCSK9 22593575 2619803 Similar to in vitro , the increased expression by pioglitazone and/or U0126 did not *result* in decreased [LDLR] expression and function . Positive_regulation LDLR PCSK9 22593575 2619805 Our results indicate that although PPAR? activation increased expression , PPAR? activation *induced* [LDLR] and CYP7A1 expression that enhanced LDL cholesterol metabolism . Positive_regulation LDLR PCSK9 22714699 2621476 *promotes* degradation of the [LDL receptor] , preventing its transport back to the cell surface and thereby increasing circulating LDL-C . Positive_regulation LDLR PCSK9 22848640 2635910 Annexin A2 is a natural extrahepatic inhibitor of the *induced* [LDL receptor] degradation . Positive_regulation LDLR PCSK9 23105118 2707057 *enhances* the cellular degradation of the [LDL receptor (LDLR)] , leading to increased plasma LDL cholesterol . Positive_regulation LDLR PCSK9 23221398 2731345 is *involved* in the degradation of [LDLR] and VLDLR . Positive_regulation LDLR PCSK9 23317404 2769562 A higher activity of *leads* to lower liver [LDLR] levels , resulting in a reduction in LDL-uptake from circulation , and thus in hypercholesterolemia and associated atherosclerosis . Positive_regulation LDLR PCSK9 23509406 2777085 *mediated* degradation of the [LDL receptor] generates a 17 kDa C-terminal LDL receptor fragment . Positive_regulation LDLR PCSK9 23509406 2777086 In this study , we have shown that *mediated* degradation of the full-length 160 kDa [LDLR] generates a 17 kDa C-terminal LDLR fragment . Positive_regulation LDLR PCSK9 23675525 2785378 can also *mediate* the degradation of [LDLR] lacking its cytosolic tail , suggesting the presence of as yet undefined lysosomal targeting factor ( s ) . Positive_regulation LDLR PCSK9 24144304 2889459 A truncated LDLR consisting of the ectodomain ( ED-LDLR ) was used for these studies to avoid *mediated* degradation of the [LDLR] . Positive_regulation LDLR PCSK9 24486405 2918538 Studies were performed to determine whether excess levels of was *sufficient* to induce [PCSK9/LDL receptor] complex formation in human hepatocyte-like C3A cells . Positive_regulation LDLR TNF 1618817 191370 *Induction* of [low density lipoprotein receptor] and a transcription factor SP-1 by in human microvascular endothelial cells . Positive_regulation LDLR TNF 1618817 191374 *induced* enhancement of [LDL receptor] gene expression was not observed when cycloheximide was present . Positive_regulation LDLR TNF 1618817 191375 The *induction* of [LDL receptor] by might be mediated through a transcription factor , SP-1 . Positive_regulation LDLR TNF 7861934 287171 In order to know whether TNF upregulates LDL receptors by depletion of the cellular cholesterol content , the present experiments were designed to study the temporal relationship between *stimulated* expression of [LDL receptor] activity and TNF induced changes in lipid synthesis and secretion in an in vitro setting by using Hep G2 cells ( a highly differentiated human hepatoma cell line ) as a hepatocyte model . Positive_regulation LDLR TNF 8349628 227083 Pretreatment with cycloheximide prevented induction of LDL receptor mRNA by TNF , but not by IL-1 , suggesting *stimulation* of [LDL receptor] transcription by requires protein synthesis . Positive_regulation LDLR TNF 9624172 511382 Differential roles of extracellular signal regulated kinase-1/2 and p38 ( MAPK ) in interleukin-1beta- and *induced* [low density lipoprotein receptor] expression in HepG2 cells . Positive_regulation LDLR TNF 9624172 511389 Northern analysis demonstrated that IL-1beta or significantly *increased* [LDL receptor] transcript in HepG2 cells , whereas expression of another tightly regulated sterol-responsive squalene synthase gene was unaffected . Positive_regulation LDLR TNF 9624172 511395 Similarly , *induced* [LDL receptor] expression also required ERK-1/2 activation . Positive_regulation LDLR TNF 9624172 511396 These results show that IL-1beta- or *induced* [LDL receptor] expression requires ERK-1/2 activation , that the p38 ( MAPK ) pathway negatively regulates LDL receptor expression , and that sterols inhibit induction at a point downstream of ERK-1/2 in HepG2 cells . Positive_regulation LDLR TNF 9840652 552791 Recombinant soluble TNF receptors inhibited the *induced* stimulation of [low-density lipoprotein receptor] in a concentration dependent manner . Positive_regulation LEF1 AXIN2 10428961 633442 To understand the mechanism by which Dvl acts through GSK to regulate LEF-1 , we investigated the *roles* of and Frat1 in Wnt mediated activation of [LEF-1] in mammalian cells . Positive_regulation LEF1 AXIN2 11336703 812114 In contrast , LRP-5 mutants lacking the extracellular domain functioned as constitutively active forms that bind and that *induce* [LEF-1] activation by destabilizing Axin and stabilizing beta-catenin . Positive_regulation LEF1 CCND1 22792274 2628498 We found that during gland development is elevated and localized to the gland buds , and that this *requires* the presence of [Lef1] . Positive_regulation LEF1 IL1B 19783677 2147632 We have previously shown that *induced* [lymphoid enhancer binding factor 1] ( Lef1 ) regulates the transcription of its target genes COX2 and MMP13 in mouse chondrocytes by binding to the Lef1 binding sites located in the 3 ' region . Positive_regulation LEF1 MMP28 12507936 1027423 These inhibitors also *blocked* the cytosolic accumulation of beta-catenin and nuclear formation of [beta-catenin/LEF-1] complex . Positive_regulation LEF1 MMP7 12507936 1027438 These inhibitors also *blocked* the cytosolic accumulation of beta-catenin and nuclear formation of [beta-catenin/LEF-1] complex . Positive_regulation LEF1 MMP7 19360357 2058565 TGFbeta1 dependent , *mediated* up-regulation of [beta-catenin/LEF1] signaling and TGFbeta1 activated HMGA2 pathways consequently converged with Slug overexpression , due to disassembly and further repression of E-cadherin expression , which was reproducible in the epithelial mesenchymal transition process without any manipulation . Positive_regulation LEFTY1 EPHB2 22441145 2612770 Transforming growth factor ß and signaling *regulate* the expression level of a novel tumor suppressor [Lefty] . Positive_regulation LEFTY1 MAP2K6 22441145 2612778 Transforming growth factor ß and signaling *regulate* the expression level of a novel tumor suppressor [Lefty] . Positive_regulation LEFTY2 EPHB2 22441145 2612759 Transforming growth factor ß and signaling *regulate* the expression level of a novel tumor suppressor [Lefty] . Positive_regulation LEFTY2 MAP2K6 22441145 2612767 Transforming growth factor ß and signaling *regulate* the expression level of a novel tumor suppressor [Lefty] . Positive_regulation LEO1 ALOX5 1650153 162977 Taken together , our studies indicate that [PAF] can significantly augment lung NK cell activity and that this effect is *dependent* on PKC , <5-lipoxygenase> , and extracellular calcium . Positive_regulation LEO1 ALOX5 3152458 104198 This suggests that <5-lipoxygenase> *dependent* mediators and [PAF] are involved in allergic contact dermatitis and that these mediators play only a minor role in irritant dermatitis . Positive_regulation LEO1 ALOX5 6089913 41334 The specific <5-lipoxygenase> inhibitor , 6,8-de-epoxy-6,9- ( phenylimino ) delta 6,8-prostaglandin I1 ( U-60257 ) , *inhibits* [PAF-acether] , but not leukotriene B4-mediated chemotaxis . Positive_regulation LEO1 ALOX5 8415804 234045 Although the early pulmonary vascular response ( < 10 min ) to PAF is dependent on cyclooxygenase products , the sustained response ( after 10 min ) can not be explained by either <5-lipoxygenase> or cyclooxygenase products but may be *mediated* directly by [PAF] receptors . Positive_regulation LEO1 ANGPT1 16617006 1624496 *mediated* endothelial [PAF] synthesis requires the activation of the p38 and p42/44 MAPKs , PI3K intracellular signalling pathways , and a secreted phospholipase A(2) ( sPLA ( 2 ) -V ) . Positive_regulation LEO1 CHI3L1 8245706 236930 On the other hand , the release of [platelet activating factor (PAF)] induced by opsonized particles was *enhanced* only by and not by CGP41-251 and CGP44-800 . Positive_regulation LEO1 EDN2 2051719 161797 In addition , *induced* a significant increase in the production of [PAF] by isolated glomeruli ( Basal , 81 +/- 10 pg/mg protein ; endothelin , 10 ( -7 ) M , 140 +/- 18 pg/mg protein ) . Positive_regulation LEO1 EDN2 8898708 393090 *stimulates* phosphoinositide hydrolysis and [PAF] synthesis in brain microvessels . Positive_regulation LEO1 HBEGF 17322418 1747800 Increased alkaline phosphatase ( AP ) activity after PAF treatment in AP-HB-EGF fusion construct transfected SMCs indicated that [PAF] *induced* the release of within 1 min. Gelatin zymography data showed that PAF stimulated MMP-2 activity and MMP-9 activity within 1 min . Positive_regulation LEO1 IL1B 10447739 577418 We conclude that CRH and [PAF] can *induce* the expression of , but this is not obligatory for increased PGE2 release , and the effect of these stimuli on COX-2 expression is a direct , IL-1beta independent effect . Positive_regulation LEO1 IL1B 1519663 196916 Stimulation of isolated mouse alveolar macrophages with recombinant murine or IL-1 alpha *resulted* in rapid , dose dependent , and cell concentration dependent increases in [PAF] secretion . Positive_regulation LEO1 IL1B 16807360 1612755 In circular muscle , exogenous [PAF] *induced* sequential formation of IL-6 , H ( 2 ) O ( 2 ) , , and PAF . Positive_regulation LEO1 IL1B 16829183 1591458 Both TNF-alpha and induced HUVEC platelet activating factor (PAF) production and [PAF] was *required* for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine ) . Positive_regulation LEO1 IL1B 7882558 298866 and IL-6 *stimulate* the production of [platelet activating factor (PAF)] by cultured rabbit synovial cells . Positive_regulation LEO1 IL1B 8080039 270826 and tumor necrosis factor-alpha *induce* [PAF] production by endothelium , and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist . Positive_regulation LEO1 ITGB2 7902855 245064 Ligation of was not *sufficient* for [PAF] synthesis suggesting that an additional receptor was involved . Positive_regulation LEO1 LBP 7541418 310469 Moreover , LeuM3 , 28C5 , and 18E12 mAbs that were themselves unable to stimulate the synthesis of PAF blocked [PAF] synthesis *initiated* by complex . Positive_regulation LEO1 LBP 7541418 310474 was *required* for synthesis of [PAF] by MO . Positive_regulation LEO1 MAP2K6 10606930 655856 The results showed that TNF alpha , IL-1 alpha and [PAF] *induced* serine phosphorylation of MKK3 and , and p38 MAP kinase activation in BECs . Positive_regulation LEO1 MUC16 9620929 510822 In rat tracheas studied by in situ hybridization , [PAF] *induced* MUC5 gene expression in epithelial cells that stained for mucosubstances . Positive_regulation LEO1 PLAT 1521562 196956 Using a perfused rat hindleg system , release of from endothelial cells could be *induced* by [platelet activating factor (PAF)] , bradykinin , substance P , thrombin , carbachol and A23187 , while this release was inhibited by mepacrine and by nor-dihydroguaiaretic acid . Positive_regulation LEO1 TGM2 7679111 211217 The finding that competitive inhibitors of significantly *inhibited* [C-PAF] release , enhancement of MC540 staining , and externalization of phosphatidylserine , strongly suggest a role for this enzyme in the enhancement of phospholipid transbilayer movement . Positive_regulation LEO1 TNF 10409262 630062 Both and interleukin-1 modestly *increased* plasma [PAF-AH] activity and mRNA levels in liver and spleen , suggesting that they may partly mediate the effect of LPS on PAF-AH . Positive_regulation LEO1 TNF 10435033 634218 ( 4 ) the synthesis of [PAF] *induced* by . Positive_regulation LEO1 TNF 11080081 749570 *increased* the production of [PAF] and NO . Positive_regulation LEO1 TNF 12428690 1014874 Synthesis of [PAF] was not *inducible* by in murine F10-M3 melanoma cells . Positive_regulation LEO1 TNF 15702351 1382775 Finally , up to 2 mug/ml , [PAF] did not *induce* the production of pro-inflammatory cytokines such as IL-6 , IL-8 , and . Positive_regulation LEO1 TNF 1668105 176691 [PAF] *induced* maximal synthesis 2-3 hr after monocyte stimulation as assessed by dot blotting of cell associated TNF alpha using polyclonal anti-TNF antibody . Positive_regulation LEO1 TNF 16829183 1591457 Both and IL-1beta induced HUVEC platelet activating factor (PAF) production and [PAF] was *required* for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine ) . Positive_regulation LEO1 TNF 18180165 1863040 *induces* [platelet activating factor (PAF)] synthesis in many inflammatory cells . Positive_regulation LEO1 TNF 18180165 1863045 We found that , although both cultures synthesized PAF at a similar basal rate , *induced* [PAF] synthesis in adipocytes was 7-fold higher than in preadipocytes . Positive_regulation LEO1 TNF 18180165 1863050 Wortmannin enhanced *dependent* [PAF] synthesis in adipocytes but not in preadipocytes , indicating the negative control by PI3K in mature cells . Positive_regulation LEO1 TNF 20016469 2204616 , which is assumed to mediate the interaction between mesangial cells and podocytes , also *induces* the expression of [platelet activating factor (PAF)] . Positive_regulation LEO1 TNF 20423922 2437240 In rats , increased hydraulic conductivity 2.5-fold over baseline and [PAF] *increased* it 5-fold ; Positive_regulation LEO1 TNF 2137857 128815 The peptide HDMNKVLDL ( antiflammin-2 ) inhibits the synthesis of [platelet activating factor (PAF)] *induced* by or phagocytosis in rat macrophages and human neutrophils , and by thrombin in vascular endothelial cells . Positive_regulation LEO1 TNF 2266661 147303 Inhibitors of PAF synthesis , such as plasma alpha 1-proteinase inhibitor and an anti-inflammatory peptide , blocked changes induced by TNF , PAF receptor antagonists inhibited changes *induced* by [PAF] and also by . Positive_regulation LEO1 TNF 2801951 119980 Since *stimulates* [PAF] synthesis in vitro , we tested the hypothesis that PAF mediates TNF induced lung injury in vivo using specific PAF receptor antagonists . Positive_regulation LEO1 TNF 3049910 99313 and IL-1 *stimulate* the synthesis and release of [platelet activating factor (PAF)] by neutrophils and vascular endothelial cells . Positive_regulation LEO1 TNF 3049910 99319 Low concentrations of this antiproteinase and of human plasma alpha 1-antichymotrypsin inhibited *induced* [PAF] synthesis in neutrophils , macrophages , and vascular endothelial cells . Positive_regulation LEO1 TNF 3119758 80239 Synthesis of [PAF] in *response* to was also detected in rat polymorphonuclear neutrophils , but not in human tumor cells and dermal fibroblasts . Positive_regulation LEO1 TNF 3261295 95994 About 30 % of [PAF] produced in *response* to either or IL-1 is released into the medium , whereas approximately 70 % remains cell associated . Positive_regulation LEO1 TNF 3261295 96010 Experiments with labeled precursors show that [PAF] is synthesized de novo in *response* to . Positive_regulation LEO1 TNF 3261295 96020 This suggests that [PAF] is synthesized by the same pathway in *response* to or IL-1 . Positive_regulation LEO1 TNF 3366898 93072 In the present study , we have shown that ( a ) *caused* [PAF] production in bowel tissue ; Positive_regulation LEO1 TNF 7516414 257609 These results suggest that the angiogenic effect of is , at least in part , *mediated* by [PAF] synthesized from monocytes and/or endothelial cells infiltrating the Matrigel plug . Positive_regulation LEO1 TNF 7681399 214261 In conclusion , the *enhancement* of [PAF] responses by , associated with functional characteristics of differentiation in Mono Mac 6 cells , may represent a specific mechanism of cooperative interaction between PAF and TNF in inflammation , sepsis , immunoregulation and atherogenesis . Positive_regulation LEO1 TNF 7821968 285556 We have shown previously that endotoxin , tumour necrosis factor (TNF) and platelet activating factor (PAF) are important in the pathogenesis of bowel injury , and that endotoxin and *induce* [PAF] formation in bowel tissue . Positive_regulation LEO1 TNF 7882905 289173 Because the release of [PAF] is *stimulated* by , this study was designed to measure the effects of polyI : C on TNF induced lung inflammation and injury . Positive_regulation LEO1 TNF 8080039 270825 Interleukin-1 beta and *induce* [PAF] production by endothelium , and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist . Positive_regulation LEO1 TNF 9394802 468198 These data suggest that [PAF] , which is released immediately or shortly after LPS injection , *induces* the expression of through the activation of NF-kappa B . Positive_regulation LEP ADAMTS1 15629898 1362331 Rather , [leptin] *induced* hyperemia and leakage in the follicle , as well as the proteinase ( a disintegrin and metalloproteinase with a thrombospondin-like motif ) , which facilitates extrusion of the follicular content . Positive_regulation LEP ARSA 15024038 1257103 The area of *induced* gastric lesions , gastric blood flow ( GBF ) , expression of mRNA and protein of [leptin] and plasma leptin , gastrin , interleukin-1beta , and tumor necrosis factor-alpha levels were examined . Positive_regulation LEP CCND1 20643953 2297772 We further show that [leptin] can *induce* Bcl-2 and expression by two pathways , including the direct activation of their promoters and suppression of microRNAs ( miRNAs ) that target their putative 3'untranslated regions . Positive_regulation LEP CCND1 23300886 2712447 [Leptin] *induces* expression and proliferation of human nucleus pulposus cells via JAK/STAT , PI3K/Akt and MEK/ERK pathways . Positive_regulation LEP CCND1 23300886 2712475 Taken together , we show that [leptin] *induces* human NP cell expression and proliferation via activation of JAK/STAT3 , PI3K/Akt or MEK/ERK signaling . Positive_regulation LEP EPHB2 15319373 1303756 [Leptin] as a novel profibrogenic cytokine in hepatic stellate cells : mitogenesis and inhibition of apoptosis *mediated* by and Akt phosphorylation . Positive_regulation LEP EPHB2 15319373 1303762 Further , the PI-3 kinase inhibitor LY294002 and MAPK inhibitor PD98059 were found to significantly reduce leptin induced HSC proliferation , thereby indicating that [leptin] induced HSC proliferation is Akt- and *dependent* . Positive_regulation LEP EPHB2 19066310 2035568 Biochemical , pharmacological , and physiological approaches were combined to characterize [leptin] *activation* of in the hypothalamus in rats . Positive_regulation LEP EPHB2 21403648 2447980 Our results suggest that CCL3 effects on [OBs] are *mediated* by activation and subsequent downregulation of the osteogenic transcription factor osterix . Positive_regulation LEP EPHB2 22431513 2588290 Biochemical analyses showed a physical association of Shp2 with estrogen receptor alpha , which is necessary for the synergistic and persistent *activation* of by [leptin] and estrogen . Positive_regulation LEP EPHB2 24063596 2888314 [Leptin] expression was *suppressed* by AngII receptor blockers , an ROS scavenger [ NAC ( N-acetylcysteine ) ] , an ( extracellular-signal regulated kinase ) pathway inhibitor ( PD98059 ) and ERK siRNA . Positive_regulation LEP FAS 15941644 1458641 Despite the decrease of food intake , [leptin] significantly *induced* the expression of in chicken liver . Positive_regulation LEP HSD11B2 22971074 2693533 We hypothesized that CRH might attenuate syncytialisation , *induce* [leptin] , and reduce <11beta-HSD2> expression in primary villous trophoblasts , which are known features of IUGR . Positive_regulation LEP IL1B 10830276 697349 by either the iv or icv route significantly *increased* [leptin] levels in the aorta [ 1.19+/-0.10 vs. 1.92+/-0.15 ng/ml ( P = 0.0002 ) and 1.19+/-0.10 vs. 1.57+/-0.12 ng/ml ( P = 0.022 ) , respectively ] . Positive_regulation LEP IL1B 10830276 697350 These findings demonstrate a net uptake of leptin by the cerebral cortex from peripheral blood in both normal and IL-1beta treated animals and show that peripheral blood levels of [leptin] are *increased* by whether administered icv or iv . Positive_regulation LEP IL1B 11822823 892910 The *upregulation* of beta3-integrin and [leptin/leptin] receptor expression by in EEC cultures indicates that both cytokines may be implicated in embryonic-maternal cross-talk during the early phase of human implantation . Positive_regulation LEP IL1B 11997182 939272 This could suggest that through a post-translational pathway *induced* an acute increase in [leptin-secretion] , perhaps through the release of leptin from a pre formed pool within the adipose tissue . Positive_regulation LEP IL1B 16213747 1476462 However , TNF-alpha , , and TGF-beta1 *stimulated* [leptin] production from preadipocytes in the absence of mature adipocytes ( 20.6+/-5.4 ng/ml , 100.8+/-18.2 ng/ml , and 5.4+/-0.4 ng/ml , respectively , compared to 6.6+/-0.8 ng/ml in control adipocyte cultures on day 21 ; n=4 ) . Positive_regulation LEP IL1B 17283229 1698235 Despite this reduction of lipid-laden adipocytes , TNF-alpha , IL-6/sIL-6R , and *stimulated* [leptin] release . Positive_regulation LEP IL1B 17419800 1766226 [Leptin] *induces* release from rat microglial cells through a caspase 1 independent mechanism . Positive_regulation LEP IL1B 17419800 1766230 Western blot analysis demonstrated that [leptin] *induced* the synthesis of in microglial cells and the release of mature 17 kDa isoform into the culture medium . Positive_regulation LEP IL1B 18263705 1911475 Chronic high glucose concentrations and [leptin] *induce* secretion from pancreatic islets , an event that is possibly causal in promoting beta-cell dysfunction and death . Positive_regulation LEP IL1B 18547319 1952264 In vitro , both leptin and resistin could induce CXCL8 and tumour necrosis factor-alpha production by blood monocytes , and [leptin] could additionally *induce* and IL-1 receptor antagonist production . Positive_regulation LEP IL1B 20506629 2263991 *regulates* metalloproteinase activity and [leptin] secretion in a cytotrophoblast model . Positive_regulation LEP IL1B 20506629 2263994 We found that activates matrix metalloproteinase activity as well as *increases* [leptin] secretion . Positive_regulation LEP IL1B 9458919 484655 *mediates* [leptin] induction during inflammation . Positive_regulation LEP IL1B 9458919 484658 To investigate the *role* of and IL-6 in [leptin] expression during inflammation , we used IL-1 beta-deficient ( -/- ) and IL-6 -/- mice . Positive_regulation LEP IL1B 9458919 484662 We conclude that is *essential* for [leptin] induction by both LPS and turpentine in mice , but IL-6 is not . Positive_regulation LEP MAP2K6 17895242 1823952 [Leptin] *induced* a marked dependent increase in pCREB that was essential for neuroprotection following 6-OHDA toxicity . Positive_regulation LEP MAP2K6 23201486 2736313 Detailed acute and chronic studies with the use of metabolic inhibitors revealed that both JAK/STAT3 and MEK/MAPK but not PI3-K/AKT/GSK-3ß signaling pathways were activated by [leptin] , and that STAT3 ( Y ( 705 ) P-STAT3 ) and ( T ( 202/ ) Y ( 204 ) P-ERK1/2 ) *mediate* these effects . Positive_regulation LEP MMP28 15306556 1333291 Our results suggest that [leptin] may play a role in the establishment of the placenta during early pregnancy and that this function is *dependent* on activity . Positive_regulation LEP MMP7 15306556 1333306 Our results suggest that [leptin] may play a role in the establishment of the placenta during early pregnancy and that this function is *dependent* on activity . Positive_regulation LEP TNF 10526261 654181 The aim of this study was to characterize the *role* of and transforming growth factor (TGF)-beta1 in depot-specific secretion of [leptin] from cultured human adipocytes . Positive_regulation LEP TNF 10666158 665390 *induces* [leptin] production through the p55 TNF receptor . Positive_regulation LEP TNF 10666158 665391 The results using all four strategies show that the *induction* of [leptin] production by requires activation of the p55 TNFR and that although activation of the p75 TNFR alone can not cause leptin production , its presence affects the capability of TNF-alpha to induce leptin production through the p55 TNFR . Positive_regulation LEP TNF 10687854 669928 In contrast , ( 4-8-h treatment ) *resulted* in a 4-fold increase in [leptin] release . Positive_regulation LEP TNF 10687854 669930 We conclude that *stimulates* the release of preformed [leptin] from human mature adipocytes and existing differentiated preadipocytes , which may contribute to obesity/infection linked hyperleptinemia , and that TNF-alpha inhibits leptin synthesis via inhibition of preadipocyte differentiation and induction of adipocyte dedifferentiation . Positive_regulation LEP TNF 10690850 670426 P < 0.05 ) was detected by 24 h . ( 10 ng/mL ) *had* no effect on dexamethasone ( 0.1 micromol/L ) -stimulated [leptin] production in sc adipocytes . Positive_regulation LEP TNF 11758007 887625 The expression of [leptin] , an adipocyte derived protein , is *regulated* by . Positive_regulation LEP TNF 11959686 931419 Both compounds completely abolished *induced* increases in [leptin] production . Positive_regulation LEP TNF 11959686 931421 PGJ treatment markedly blunted the *induced* increase in [leptin] , TNF-alpha , and interleukin-6 gene expression in epididymal adipose tissue . Positive_regulation LEP TNF 11959686 931422 Collectively , these data indicate that acutely *activates* [leptin] expression and that anti-inflammatory agents can abrogate TNF-alpha induced hyperleptinemia . Positive_regulation LEP TNF 12200753 982939 Since TNF-alpha also induces hyperinsulinemia , and because insulin is a potent stimulator of leptin production , we hypothesized that elevated plasma insulin mediates *induced* increases of circulating [leptin] . Positive_regulation LEP TNF 12200753 982942 In nondiabetic rats , increased plasma insulin ( P =.016 ) and *prevented* the fasting induced decrease of circulating [leptin] ( P =.004 ) over the initial 12 hours compared with vehicle . Positive_regulation LEP TNF 14559934 1153945 The objective of this study was to examine whether increased , a pro-inflammatory cytokine , *contributes* to the abnormally elevated [leptin] in IL-2 ( -/- ) mice . Positive_regulation LEP TNF 15114059 1241398 Our data showed that [leptin] *induced* , interleukin-6 , and interleukin-10 production by PBMCs of patients in an acute phase of disease but not in patients in a stable phase or in healthy controls . Positive_regulation LEP TNF 15194576 1260087 [Leptin] is *stimulated* by and is associated with hypoandrogenicity in non-inflammatory conditions . Positive_regulation LEP TNF 15784704 1410093 Pharmacological neutralization of TNFalpha with infliximab offers a unique opportunity to study *mediated* regulation of [leptin] in CD patients . Positive_regulation LEP TNF 15917841 1440334 *increased* the mRNA levels of TNFalpha itself as well as IL-6 , IL-8 , IL-1beta and PAI-1 , but not [leptin] . Positive_regulation LEP TNF 16080843 1442757 Serum levels of TNFalpha and leptin in obese subjects are closely related with insulin resistance , indicating that high level of may *promote* release of [leptin] for the modulation of adipocyte . Positive_regulation LEP TNF 16213747 1476461 However , , IL-1beta , and TGF-beta1 *stimulated* [leptin] production from preadipocytes in the absence of mature adipocytes ( 20.6+/-5.4 ng/ml , 100.8+/-18.2 ng/ml , and 5.4+/-0.4 ng/ml , respectively , compared to 6.6+/-0.8 ng/ml in control adipocyte cultures on day 21 ; n=4 ) . Positive_regulation LEP TNF 16403817 1540149 Synergistic effects of increased local or systemic in combination with glucocorticoids may *contribute* to increased [leptin] expression in response to stress , including infection and obesity . Positive_regulation LEP TNF 17283229 1698234 Despite this reduction of lipid-laden adipocytes , , IL-6/sIL-6R , and IL-1beta *stimulated* [leptin] release . Positive_regulation LEP TNF 18535101 1965733 Adiponectin and [leptin] , and adipocyte-specific genes of adiponectin , leptin , and PPAR-gamma were *detected* in culture assembly , whereas the lipogenesis factor insulin ( 20 mU/ml ) and inflammation related agent ( 2 nm ) increased and decreased , respectively , all of their displays . Positive_regulation LEP TNF 22048440 2700592 was also found to *enhance* synthesis of [leptin] . Positive_regulation LEP TNF 22048440 2700593 It is possible that *induced* [leptin] secretion contributes to body mass reduction in patients with RA . Positive_regulation LEP TNF 8621806 360172 and IL-1 , mediators of the host response to LPS , also induced anorexia and *increased* levels of [leptin] in mRNA in adipose tissue . Positive_regulation LEP TNF 9388486 466979 When considered in the context of animal studies showing that interleukin-1 and *induce* [leptin] and ob mRNA , these results suggest that pro-inflammatory cytokines induce ob gene transcription in vivo via secondary mediators such as transforming growth factor-beta . Positive_regulation LEP TNF 9564834 500794 To examine the *role* of in mediating [leptin] secretion during an immunological challenge , we studied the effects of lipopolysaccharide (LPS) and TNF alpha on leptin secretion in endotoxin-sensitive C3H/HeOuJ ( OuJ ) mice , endotoxin-insensitive C3H/HeJ ( HeJ ) mice , and primary adipocytes cultured from both . Positive_regulation LEP TNF 9564834 500797 To determine whether *induces* [leptin] secretion by acting directly on fat cells , primary adipocytes from OuJ and HeJ mice were cultured in the presence of TNF alpha or LPS . Positive_regulation LEP TNF 9874578 583580 Since also *induces* [leptin] , a hormone secreted by adipocytes that modulates food intake and metabolism , we questioned the role of leptin in TNF induced pathology . Positive_regulation LEPR CLU 23673647 2785258 In *response* to , the low-density lipoprotein receptor related protein-2 binding to long-form [leptin receptor] is greatly enhanced in cultured neuronal cells . Positive_regulation LEPR IL1B 11822823 892911 The *upregulation* of beta3-integrin and [leptin/leptin receptor] expression by in EEC cultures indicates that both cytokines may be implicated in embryonic-maternal cross-talk during the early phase of human implantation . Positive_regulation LEPR TNF 23070544 2703396 We found that in a wide range of concentrations *up-regulated* LEPRb protein level and soluble [LEPR] ( sLEPR ) release via ectodomain shedding of LEPRb in multiple cell types , including neuronal cells . Positive_regulation LGALS1 EPHB2 19048108 1999254 A phospholipase Cgamma (PLCgamma) inhibitor and shRNA , as well as an inhibitor , *reduced* [ST6Gal1] and FUT9 mRNA levels and inhibited effects of L1 on neurite outgrowth and cell survival . Positive_regulation LGALS1 IL1B 8033820 264138 The stimulatory effect of IL-6 on hPL release and hPL mRNA levels was dose dependent , with a minimal effective dose of 50 U/ml . , which is known to stimulate IL-6 production by human trophoblast cells , also *stimulated* dose dependent increases in hPL release and [hPL] mRNA levels . Positive_regulation LGALS1 SLC38A3 3732165 61622 ( diC8 ) and phorbol-12-myristate-13-acetate ( PMA ) , both of which stimulate placental protein kinase C activity , *caused* dose dependent increases in [hPL] release over a 0.5-h period . Positive_regulation LGALS1 SUSD2 23131994 2729435 Interestingly , we found that localization of [Gal-1] on the surface of cells is *dependent* on the presence of . Positive_regulation LGALS3 CCND1 10463621 640213 Interestingly , [galectin-3] *induces* expression ( an early G1 cyclin ) and its associated kinase activity in the absence of cell anchorage . Positive_regulation LGALS3 CCND1 15520318 1335661 Recombinant [galectin-3] *induced* cardiac fibroblast proliferation , collagen production , and expression . Positive_regulation LGALS3 TGM2 7875321 296702 *mediated* cross linking of [galectin 3] to itself or to matrix components may be one mechanism for stabilisation of a multivalent binding form of the lectin in cell secretions or in extracellular matrices . Positive_regulation LGALS3 TGM2 9791724 542502 *mediated* oligomerization of [galectin-3] modulates human melanoma cell interactions with laminin . Positive_regulation LGALS3 TNF 14558084 1153673 The intracellular accumulation of [galectin 3] can be *enhanced* by . Positive_regulation LGALS3 TNF 17259811 1696703 [Galectin-3] expression was *induced* by and interferon (IFN)-gamma in a monocytic cell line U937 . Positive_regulation LGALS3 TNF 17259811 1696707 [Galectin-3] also *induced* mRNA expression and protein production of and interleukin (IL)-8 in a macrophage cell line THP-1 . Positive_regulation LGALS4 EPHB2 15020583 1243428 Further investigation on the effects of the three MAPK pathways on Nrf2 transactivation domain activity demonstrated that both and JNK signaling pathways *stimulated* the [Gal4-Nrf2-] ( 1-370 ) transactivation activity while the p38 pathway played a negative role . Positive_regulation LGALS4 PGC 10669761 666580 also *enhanced* the transactivation activity of a [PPARalpha-Gal4] DNA binding domain fusion protein . Positive_regulation LGALS4 TNF 22691873 2633662 Herein , we show that the pro-inflammatory cytokine *increases* the expression of a2,3-sialyltransferase gene [ST3GAL4] , both in human bronchial mucosa and in A549 lung carcinoma cells . Positive_regulation LGALS4 TNF 24099577 2888776 In the present study , we show that the *induced* up-regulation of the [ST3GAL4] BX transcript is mediated by MSK1/2 ( mitogen- and stress activated kinase 1/2 ) through the ERK ( extracellular-signal regulated kinase ) and p38 MAPK ( mitogen activated protein kinase ) pathways , and increases sLe ( x ) expression on high-molecular-mass glycoproteins in inflamed airway epithelium . Positive_regulation LGALS7 GPI 22517622 2624736 Expression levels of endometrial GRP , IGFBP1 , and [LGALS15] , whose products stimulate trophectoderm cell migration and attachment , were *increased* by PGE2 , , and IFNT . Positive_regulation LGALS7B AGXT 15531585 1360337 Additional analysis suggests that is *required* for cotranscriptional association of the factor Ctr9 , a member of the Paf1 complex , with GAL10 and [GAL7] , and that Ctr9 association with chromatin 3 ' of GAL10 is regulated by the GAL10 polyadenylation signal . Positive_regulation LGALS7B CISH 24134186 2875114 DNA microarray analysis and real-time PCR investigation revealed that , not trans-UCA , *increased* the expression of a gene encoding a ß-galactoside binding lectin , galectin-7 , [LGALS7B] . Positive_regulation LGALS7B JDP2 23530091 2762257 [Galectin-7] accumulation was mediated through JNK inhibition presumably resulting from the observed induction of p53 , and was negatively *regulated* by the AP-1 inhibitor . Positive_regulation LGALS7B PTGS2 22251572 2551256 Finally , we demonstrated that EC-SOD induced [galectin-7] *results* from the production of . Positive_regulation LGALS7B SOD3 22251572 2551252 *induces* apoptosis through COX-2 and [galectin-7] in the epidermis . Positive_regulation LGALS7B SOD3 22251572 2551254 This suggests that *induces* apoptosis through increased [galectin-7] expression . Positive_regulation LGALS7B SOD3 22251572 2551255 Finally , we demonstrated that *induced* [galectin-7] results from the production of COX-2 . Positive_regulation LGALS7B TP53 23967302 2832714 Expression of [galectin-7] is *induced* in breast cancer cells by mutant . Positive_regulation LGALS7B TP53 23967302 2832715 The p53 induced galectin-7 expression in breast cancer cells correlated with increased NF-?B activity and was inhibited by NF-?B inhibitors , indicating that the ability of mutant to *induce* [galectin-7] was dependent on NF-?B activity . Positive_regulation LGALS9 IL1B 11726788 884499 *stimulates* [galectin-9] expression in human astrocytes . Positive_regulation LGALS9 IL1B 11726788 884500 was found to *enhance* the [galectin-9] expression in time- and concentration dependent manners . Positive_regulation LGALS9 IL1B 11726788 884501 We conclude that astrocytes produce [galectin-9] in *response* to the stimulation with , and this may contribute to inflammatory reactions in the CNS . Positive_regulation LGALS9 TNF 23836896 2829270 In contrast , IL-1ß , IFN-? , and particularly *up-regulated* [Gal-9] in astrocytes . Positive_regulation LGALS9 TNF 23836896 2829272 *induced* [Gal-9] expression was dependent on TNF receptor 1 (TNFR1) as TNF failed to induce Gal-9 in TNFR1 ( -/- ) astrocytes . Positive_regulation LGALS9 TNF 23836896 2829273 Blockade of the JNK MAP kinase pathway with the JNK inhibitor SP600125 abrogated *induced* [Gal-9] , whereas p38 and MEK inhibitors had minimal effects . Positive_regulation LGALS9 TNF 23836896 2829275 Furthermore , specific knockdown of c-Jun via siRNA in astrocytes before TNF treatment greatly suppressed Gal-9 transcription , suggesting that *induces* astroglial [Gal-9] through the TNF/TNFR1/JNK/cJun signaling pathway . Positive_regulation LGALS9 TNF 23836896 2829276 Finally , utilizing astrocytes from Lgals9 mutant ( Gal-9 ( -/- ) ) mice as well as a myelin basic protein-specific Tim-3 ( + ) encephalitogenic T-cell clone ( LCN-8 ) , we found that conditioned medium from *stimulated* [Gal-9] ( +/+ ) but not Gal-9 ( -/- ) astrocytes increased the percentage of apoptotic encephalitogenic T-cells . Positive_regulation LGALS9 TNF 23836896 2829277 Together , our results suggest that [Gal-9] is *induced* in astrocytes by via the JNK/c-Jun pathway and that astrocyte derived Gal-9 may function as an immunoregulatory protein in response to ongoing neuroinflammation . Positive_regulation LGMN CST6 20074384 2205643 These results suggest that the level of *regulates* [legumain] activity and hence the invasive potential of human melanoma cells . Positive_regulation LGMN CST6 22902879 2687710 Furthermore , auto-activation of secreted prolegumain was inhibited by cystatin E/M , which for the first time shows a regulatory *role* of in controlling both intra- and extracellular [legumain] activity . Positive_regulation LHCGR FOXO1 23754802 2820132 [Lhcgr] expression in granulosa cells : *roles* for PKA phosphorylated ß-catenin , TCF3 , and . Positive_regulation LHX2 PLAU 23864708 2835154 *regulates* [Lhx2] expression by suppressing expression of miR-124 and p53 expression by repressing its promoter by inactivating HOXA5 . Positive_regulation LHX4 SP1 18053794 1846672 We conclude directly *regulates* [Lhx4] gene expression . Positive_regulation LHX4 TRIM26 21965270 2507362 Using in silico analysis , the evolutionary conserved region within the AFP promoter containing LHX4 binding site was identified , implying that is a putative *target* for [LHX4] . Positive_regulation LHX8 OSR1 23383144 2739520 Ectopic expression of WNK1 , WNK4 or in mammalian cells *induced* the expression of the [Lhx8] . Positive_regulation LIF EPHB2 10217263 608362 These results indicate that [LIF] mRNA levels can be *regulated* by activation via stimulation of PKC in Schwann cells . Positive_regulation LIF EPHB2 20570039 2308967 activation was *sufficient* to induce growth inhibition and [LIF] expression in the human MTC line MZ-CRC-1 . Positive_regulation LIF FAS 20926603 2375721 Caspases were activated upon Fas-stimulation and the *mediated* effects on [LIF] , IL-11 and -8 were reversed by caspase-inhibition . Positive_regulation LIF HBEGF 17822789 1817480 According to our data , *increased* transcription of IL-6 , cardiotrophin-1 (CT-1) , [leukemia inhibitory factor (LIF)] and ciliary neurotrophic factor (CNTF) . Positive_regulation LIF IL1B 10704254 672821 In every case , [LIF] production was *enhanced* by and inhibited by IL-4 or dexamethasone , except in two severe rejection episodes . Positive_regulation LIF IL1B 1522240 197076 Cycloheximide was a potent LIF mRNA inducer and dexamethasone inhibited [LIF] *induced* by PMA or . Positive_regulation LIF IL1B 15613280 1357429 *induces* expression of [leukemia inhibitory factor (LIF)] and activation of STAT3 via the MEK/ERK pathway . Positive_regulation LIF IL1B 18801170 1969502 Stimulation with *increased* [LIF] production . Positive_regulation LIF IL1B 7583237 333545 This suggests that the stimulatory effects of on SPR mRNA in explants is *mediated* by [LIF] release . Positive_regulation LIF IL1B 8913777 395632 *increases* [leukemia inhibitory factor] mRNA levels through transient stimulation of transcription rate . Positive_regulation LIF IL1B 8913777 395633 *induces* [leukemia inhibitor factor (LIF)] expression in a number of cell types including non-neuronal cells of the sympathetic superior cervical ganglion (SCG) . Positive_regulation LIF IL1B 8913777 395635 *increases* [LIF] mRNA levels by interacting with IL-1 receptors in SCG , since this induction could be diminished by inclusion of either soluble IL-1 receptors or IL-1 receptor antagonist . Positive_regulation LIF IL1B 8913777 395636 These results suggest that the *induction* of [LIF] gene expression is at least partially transcriptional , but that LIF mRNA increases to a greater extent than LIF transcription , suggesting the possibility of posttranscriptional regulation as well . Positive_regulation LIF IL1B 9564823 500752 In conclusion , corticotroph [LIF] mRNA expression is specifically *stimulated* by and tumor necrosis factor-alpha . Positive_regulation LIF IL1R2 15142989 1273088 Leptin induced increase in [leukemia inhibitory factor] and its receptor by human endometrium is partially *mediated* by signaling . Positive_regulation LIF MAP2K6 20570039 2308973 activation was *sufficient* to induce growth inhibition and [LIF] expression in the human MTC line MZ-CRC-1 . Positive_regulation LIF NR2F1 18177425 1951111 Specifically , overexpression *increased* mRNA levels of GATA6 by 3.3+/-0.3-fold , GATA4 by 3.6+/-0.1-fold , laminin B1 (LAMB1) by 3.4+/-0.1-fold , LAMC1 by 3.4+/-0.2-fold , Dab2 by 2.4+0.1-fold , and SOX17 by 2.5-fold at 72 hr after RA treatment plus [LIF] , as compared with the increases seen in WT ES cells . Positive_regulation LIF PPBP 18707017 2020379 *Induction* of differentially expressed chemokines CXCL1-3 , CXCL5 , and CXCL6 as well as [LIF] and gp130 in MSC by was verified by real-time polymerase chain reaction . Positive_regulation LIF TNF 10698190 671746 While [LIF] production was greatly enhanced in presence of serum , lipopolysaccharide , and further *increased* this production in peritubular and Sertoli cells , and human CG enhanced Leydig cell LIF production . Positive_regulation LIF TNF 18552402 1945963 Expression of IL-6 and [leukemia inhibitory factor (LIF)] was *induced* by in wild-type and JNK2-null myoblasts . Positive_regulation LIF TNF 18552402 1945964 However , [LIF] expression was not *induced* by in JNK1-null myoblasts . Positive_regulation LIF TNF 20564184 2285228 We determined that TNFalpha treatment induced c-fos transcription , and blocking AP-1 activity resulted in a significant inhibition of *induced* [LIF] expression . Positive_regulation LIF TNF 24387170 1185218 [LIF] production was *promoted* by IL-1ß and stimulation ; Positive_regulation LIF TNF 7775640 309200 On the other hand , we showed that interleukin-1 , , platelet derived growth factor , epidermal growth factor , and transforming growth factor-beta are potent *inducers* of [LIF] expression in endometrial stromal cells in culture in a concentration- and time dependent manner . Positive_regulation LIF TNF 8432990 212941 *Induction* of [leukemia inhibitory factor] in human synovial fibroblasts by IL-1 and . Positive_regulation LIF TNF 8507220 221505 Interleukin-1 (IL-1) and *stimulated* [LIF] production by chondrocyte monolayers and cartilage . Positive_regulation LIF TNF 8592105 341925 *induces* substance P in sympathetic ganglia through sequential induction of interleukin-1 and [leukemia inhibitory factor] . Positive_regulation LIF TNF 8592105 341986 Furthermore , TNF-alpha induced LIF mRNA is blocked by the IL-1 receptor antagonist , whereas IL-1 induced LIF mRNA is not affected by TNF-alpha antibodies , suggesting that first induces IL-1 , and IL-1 subsequently *induces* [LIF] . Positive_regulation LIF TNF 8592105 341989 These data suggest that *induces* SP in sympathetic ganglia through the sequential inductions of IL-1 and [LIF] . Positive_regulation LIF TNF 8666813 369118 In addition , to assess the *role* of in the induction of [LIF] in vivo , seven baboons were studied that had either received a bolus injection of recombinant human TNF-alpha ( 100 micrograms/kg , n=3 ) , or to whom 15 mg/kg of an anti-TNF mAB before lethal E. coli challenge was administered ( n=4 ) . Positive_regulation LIF TNF 8770299 379291 4JK tumor was further tested to determine if IL-1 , , or cocultivation with RAW 264 cells *augmented* IL-6 or [LIF] production . Positive_regulation LIF TNF 8895217 392427 IL-beta and highly *stimulated* IL-6 , [LIF] and IL-8 productions . Positive_regulation LIF TNF 8987949 404136 Yet stromal cells treated with transforming growth factor-beta alone or in combination with epidermal growth factor and platelet derived growth factor , as well as alone or in combination with interleukin-1 alpha *enhanced* secretion of [leukemia inhibitory factor] at or above the levels found with epithelial cells . Positive_regulation LIF TNF 9344507 459119 Interleukin 1alpha (IL-1alpha) , IL-1beta , IL-3 , IL-6 , IL-8 , tumour necrosis factor ( ) and SCF ( both at 10 ng/ml ) *stimulate* [LIF] production . Positive_regulation LIF TNF 9564823 500751 In conclusion , corticotroph [LIF] mRNA expression is specifically *stimulated* by IL-1beta and . Positive_regulation LILRA3 TNF 20595277 2296414 Soluble [LILRA3] , a potential natural antiinflammatory protein , is increased in patients with rheumatoid arthritis and is tightly *regulated* by interleukin 10 , , and interferon-gamma . Positive_regulation LILRB2 TLR7 19860908 2160585 In addition to the high level expression that can render antigen presenting cells tolerogenic , there may be a role for lower level expression and activity of [LILRB2] and LILRB4 in *response* to signalling during an immune response to bacterial infection . Positive_regulation LILRB4 TLR7 19860908 2160595 In addition to the high level expression that can render antigen presenting cells tolerogenic , there may be a role for lower level expression and activity of LILRB2 and [LILRB4] in *response* to signalling during an immune response to bacterial infection . Positive_regulation LIMK1 CDKN1C 21769918 2494979 Further , silence of not only decreased the interaction between p57(kip2) and LIMK-1 assayed by immunoprecipitation but also *reduced* the level of [phospho-LIMK1/2] . Positive_regulation LIMK1 IL1B 12413956 1010994 Similar to exogenously added ceramide , also which is an established activator of the neutral sphingomyelinase that leads to endogenous ceramide formation *upregulates* [LIMK-1] protein expression and activity . Positive_regulation LIMK1 TNF 23702034 2811288 We show that *enhanced* the phosphorylation of [LIMK] at threonine508 and its downstream target cofilin at serine3 ( p-cofilin ( Ser3 ) ) . Positive_regulation LIMK2 IL1B 15467300 1335171 Inhibition of ROCK ( Y-27632 , 10 muM ) reduced only the *stimulated* [LIMK2] and cofilin expression . Positive_regulation LIMK2 TNF 23702034 2811289 We show that *enhanced* the phosphorylation of [LIMK] at threonine508 and its downstream target cofilin at serine3 ( p-cofilin ( Ser3 ) ) . Positive_regulation LIMS1 ANKRD1 15872073 1426203 Overexpression of the PINCH-1 binding of ILK but not that of a PINCH-1 binding defective mutant form of the ankyrin domain effectively *inhibited* the formation of the [PINCH-1-ILK-alpha-parvin] complex . Positive_regulation LIN37 AXIN2 21814488 2462845 Third , [Ppa-LIN-18/Ryk] signaling *involves* and ß-catenin and Ppa-axl-1/Axin is epistatic to Ppa-lin-18/Ryk . Positive_regulation LIN37 EPHB2 23154983 2699984 Furthermore , during vulval induction , the downstream kinase is also *required* for [LIN-45] protein degradation in a negative feedback loop , resulting in degradation of LIN-45 where ERK is highly active . Positive_regulation LIN52 AXIN2 21814488 2462837 Third , [Ppa-LIN-18/Ryk] signaling *involves* and ß-catenin and Ppa-axl-1/Axin is epistatic to Ppa-lin-18/Ryk . Positive_regulation LIN52 EPHB2 23154983 2699981 Furthermore , during vulval induction , the downstream kinase is also *required* for [LIN-45] protein degradation in a negative feedback loop , resulting in degradation of LIN-45 where ERK is highly active . Positive_regulation LIN54 AXIN2 21814488 2462839 Third , [Ppa-LIN-18/Ryk] signaling *involves* and ß-catenin and Ppa-axl-1/Axin is epistatic to Ppa-lin-18/Ryk . Positive_regulation LIN54 EPHB2 23154983 2699982 Furthermore , during vulval induction , the downstream kinase is also *required* for [LIN-45] protein degradation in a negative feedback loop , resulting in degradation of LIN-45 where ERK is highly active . Positive_regulation LIN9 AXIN2 21814488 2462843 Third , [Ppa-LIN-18/Ryk] signaling *involves* and ß-catenin and Ppa-axl-1/Axin is epistatic to Ppa-lin-18/Ryk . Positive_regulation LIN9 EPHB2 23154983 2699983 Furthermore , during vulval induction , the downstream kinase is also *required* for [LIN-45] protein degradation in a negative feedback loop , resulting in degradation of LIN-45 where ERK is highly active . Positive_regulation LINC00284 TP53 19383908 2067999 Here , we show that DNA damage results in the *dependent* binding of p130 and E2F4 to [LINC] and the dissociation of B-MYB from LINC . Positive_regulation LINC00341 TP53 19383908 2067959 Here , we show that DNA damage results in the *dependent* binding of p130 and E2F4 to [LINC] and the dissociation of B-MYB from LINC . Positive_regulation LIPA TNF 11488917 845275 The interaction of hemoglobin ( Hb ) with endotoxins [ i.e. with enterobacterial deep rough mutant lipopolysaccharide (LPS) Re and the `` endotoxic principle '' of LPS , lipid A ] was investigated using a variety of physical techniques and with two biological assays , *induction* in human mononuclear cells and the [Limulus amebocyte lysate (LAL)] assay . Positive_regulation LIPE EPHB2 12794177 1113516 Activated *increased* [HSL] activity in supernatant from basal but not from electrically stimulated muscle . Positive_regulation LIPE EPHB2 21701568 2505182 These findings demonstrate that SAA induced lipolysis is a result of downregulation of perilipin and *activation* of [HSL] via and PKA signaling pathways . Positive_regulation LIPE TNF 11681809 873924 TNF-alpha and IL-6 inhibit lipoprotein lipase , and additionally *stimulates* [hormone-sensitive lipase] and induces uncoupling protein expression . Positive_regulation LIPE TNF 19819972 2154506 Moreover , pretreatment with inhibitors of iNOS and guanylate cyclase , but not an adenylate cyclase inhibitor , abolished *induced* lipolysis and [HSL] phosphorylation . Positive_regulation LIPE TNF 19819972 2154508 In conclusion , short-term treatment induces lipolysis in 3T3-L1 adipocytes by increasing iNOS expression and NO production , which activates the guanylyl cyclase/cGMP dependent pathway and *induces* phosphorylation of [HSL] . Positive_regulation LIPG ATP5O 12805093 1134167 enzyme activity was unchanged with age in GR and GW but *increased* in [EDL] . Positive_regulation LIPG CS 8048475 267116 Relative to controls , cytochrome oxidase and activities *increased* significantly in [EDL] from treated mice , but not in SOL ; Positive_regulation LIPG HAAO 6686132 33610 In contrast with Soleus , CS activity of [EDL] *increased* with age but HK , LDH , and decreased . Positive_regulation LIPG IL4 21668966 2451203 protein levels *increased* in [EDL] at E6 , but the opposite result was observed in the soleus . Positive_regulation LIPG INS 15161746 1252897 *increased* phosphorylation of JNK , p38 MAPK , and ERK1/2 in isolated [extensor digitorum longus (EDL)] and soleus muscle from lean mice in a time- and dose dependent manner . Positive_regulation LIPG INS 3526921 62661 binding to plasma membranes *increased* in S , P , and [EDL] ( P less than 0.05 ) but not in WG ( P = 0.07 ) , RG ( P greater than 0.1 ) , or in liver ( P greater than 0.1 ) . Positive_regulation LIPG LMF1 21447484 2427637 1 is *required* for [endothelial lipase] activity . Positive_regulation LIPG LMF2 21447484 2427638 1 is *required* for [endothelial lipase] activity . Positive_regulation LIPG MSH2 2160650 133354 peptide , administered from day of birth to postnatal day 13 , *had* no effect on [EDL] muscle metabolic activity using the 2,3,5-triphenyltetrazolium chloride indicator . Positive_regulation LIPG MSH3 2160650 133355 peptide , administered from day of birth to postnatal day 13 , *had* no effect on [EDL] muscle metabolic activity using the 2,3,5-triphenyltetrazolium chloride indicator . Positive_regulation LIPG MSH4 2160650 133356 peptide , administered from day of birth to postnatal day 13 , *had* no effect on [EDL] muscle metabolic activity using the 2,3,5-triphenyltetrazolium chloride indicator . Positive_regulation LIPG MSH5 2160650 133357 peptide , administered from day of birth to postnatal day 13 , *had* no effect on [EDL] muscle metabolic activity using the 2,3,5-triphenyltetrazolium chloride indicator . Positive_regulation LIPG MSH6 2160650 133358 peptide , administered from day of birth to postnatal day 13 , *had* no effect on [EDL] muscle metabolic activity using the 2,3,5-triphenyltetrazolium chloride indicator . Positive_regulation LIPG SCARB1 19136670 2037747 [Endothelial lipase (EL)] is a negative regulator of high density lipoprotein ( HDL ) cholesterol plasma levels , and is *involved* in remodeling of HDL . Positive_regulation LITAF TNF 15593122 1361703 In the colons , a *inducing* transcription factor , [LPS induced TNF-alpha factor (LITAF)] , was inhibited by 1,25D3 , but not by calcium . Positive_regulation LITAF TNF 21663590 2464778 In our previous study , we have shown that a transcription factor LPS induced TNF factor ( [LITAF] ) significantly *induces* production . Positive_regulation LITAF TNF 23795761 2828640 Gain- and loss-of-function experiments in different B-cell lymphoma cell lines revealed that , in contrast to its function in monocytes , [LITAF] does not *induce* lipopolysaccharide mediated secretion in B cells . Positive_regulation LMNB1 IL1B 15201138 1288921 N ( G ) -monomethyl-l-arginine , a known inhibitor of inducible nitric oxide synthetase (iNOS) , markedly inhibited IL-1beta induced iNOS gene expression , NO release , caspase-3 and caspase-6 activation , lamin B degradation , and loss of metabolic cell viability , indicating that the observed *induced* effects on nuclear [lamin B] involve the intermediacy of NO . Positive_regulation LMNB1 IL1B 16830232 1586797 Based on these findings , we propose that mediated inhibition of PP4 activity might *result* in the retention of [lamin-B] in its phosphorylated state , which is a requisite for its degradation by caspases leading to the apoptotic demise of the beta cell ( Veluthakal et al. : Am J Physiol Cell Physiol 287 : C1152-C1162 , 2004 ) . Positive_regulation LMNB2 IL1B 15201138 1288922 N ( G ) -monomethyl-l-arginine , a known inhibitor of inducible nitric oxide synthetase (iNOS) , markedly inhibited IL-1beta induced iNOS gene expression , NO release , caspase-3 and caspase-6 activation , lamin B degradation , and loss of metabolic cell viability , indicating that the observed *induced* effects on nuclear [lamin B] involve the intermediacy of NO . Positive_regulation LMNB2 IL1B 16830232 1586799 Based on these findings , we propose that mediated inhibition of PP4 activity might *result* in the retention of [lamin-B] in its phosphorylated state , which is a requisite for its degradation by caspases leading to the apoptotic demise of the beta cell ( Veluthakal et al. : Am J Physiol Cell Physiol 287 : C1152-C1162 , 2004 ) . Positive_regulation LMO1 HOXB2 17676642 1788237 By analysing its expression in Hox knockout mice , we show that [Lmo1] is differentially *regulated* by Hoxa2 and , in specific columns of hindbrain neuronal progenitors . Positive_regulation LMO4 EPHB2 17524392 1772969 ATP signaling through ERK and CREB activated LMO4 promoters and activation *increased* [LMO4] protein stability in F11 cells . Positive_regulation LMO7 TNF 15383598 1298968 Lipidated ( L ) -Omp16 and [L-Omp19] , but not their unlipidated forms , *induced* the secretion of , IL-6 , IL-10 , and IL-12 in a time- and dose dependent fashion . Positive_regulation LMX1A FOXA1 19607821 2123918 Our studies show that and Foxa2 positively *regulate* [Lmx1a] and Lmx1b expression and inhibit Nkx2.2 expression in mesodiencephalic dopaminergic progenitors . Positive_regulation LMX1A WNT7A 7501017 336213 , required for normal development of the dorsoventral axis in mouse limbs , can *induce* ectopic expression of [C-Lmx1] in ventral mesoderm . Positive_regulation LMX1A WNT7A 7585966 333704 *Induction* of the LIM homeobox gene [Lmx1] by establishes dorsoventral pattern in the vertebrate limb . Positive_regulation LMX1A WNT7A 7585966 333705 Thus , the dorsalization of limb mesoderm appears to involve the *mediated* induction of [Lmx1] in limb mesenchymal cells . Positive_regulation LMX1B FOXA1 19607821 2123920 Our studies show that and Foxa2 positively *regulate* Lmx1a and [Lmx1b] expression and inhibit Nkx2.2 expression in mesodiencephalic dopaminergic progenitors . Positive_regulation LMX1B WNT7A 9362463 471989 We find that is *required* for [Lmx-1b] expression in distal limb mesenchyme , and that Lmx-1b activation in the ventral mesenchyme of En-1 mutants requires Wnt-7a . Positive_regulation LMX1B WNT7A 9463360 485263 Analysis of En1/Wnt7a double mutants demonstrates that the dorsalizing gene is *required* for the formation of the ectopic AERs in En1 mutants and for ectopic expression of [Lmx1b] in the ventral mesenchyme . Positive_regulation LOX CTGF 10616214 575829 Exogenous addition of 1 to 50 ng/ml CTGF to gingival fibroblasts stimulates production of [lysyl oxidase] enzyme activity up to 1.5-fold after 48 hours , and 50 ng/ml *stimulated* insoluble collagen accumulation 1.5- to 2.0-fold after 4 , 11 , and 18 days of treatment . Positive_regulation LOX IL1B 8872612 389688 Prostaglandin E2 , transforming growth factor-beta , and variably *regulate* the expression of cyclooxygenase 1 , cyclooxygenase 2 , and [lysyl oxidase] in IMR90 , human embryo lung fibroblasts . Positive_regulation LOX IL1B 9305751 454093 Immunofluorescence data demonstrate that *increases* cellular [12-LOX] protein . Positive_regulation LOX TNF 18174253 1875690 The expression of [p12-LOX] was significantly higher in JB6 P+ cells than in JB6 P- cells that were resistant to transformation , and its expression was further *increased* by . Positive_regulation LOX TNF 18174253 1875692 These results indicate that [p12-LOX] is *induced* by the inflammatory cytokine in the early stage of tumorigenesis , and is required for tumor promotion through enhancing efficient proliferation of a small number of initiated cells . Positive_regulation LOX TNF 20163327 2307262 Curcumin inhibits *induced* [lectin-like oxidised LDL receptor-1 (LOX-1)] expression and suppresses the inflammatory response in human umbilical vein endothelial cells ( HUVECs ) by an antioxidant mechanism . Positive_regulation LPA CAPN8 20420580 2246774 Interestingly , LPA induced down-regulation of MAG was significantly inhibited by calpain inhibitors ( calpain inhibitor X , E-64 and E-64d ) and [LPA] markedly *induced* activation in the DR . Positive_regulation LPA CCND1 20724530 2335653 In vitro studies using HCT116 cells showed that [LPA] *induced* , c-Myc , and HIF-1a expression , which was attenuated by knockdown of LPA ( 2 ) . Positive_regulation LPA CTGF 11518778 851718 [LPA] *induced* a rapid transient increase in mRNA expression , with maximal levels being observed after 1 to 2 h . Positive_regulation LPA CTGF 18003779 1827175 In vitro , [LPA] *induced* a rapid , dose dependent increase in expression that was inhibited by Ki16425 . Positive_regulation LPA CTGF 21545790 2435335 In vitro , [LPA] *induced* both fibroblast proliferation and expression in a dose dependent manner , and both were suppressed by blockade of LPAR1/3 . Positive_regulation LPA CTGF 22422617 2588065 Low-density [lipoprotein] *induced* expression of via transactivation of sphingosine 1-phosphate receptors in mesangial cells . Positive_regulation LPA EDN2 24315856 2904906 Low density [lipoprotein] *induces* upregulation of vasoconstrictive type B receptor expression . Positive_regulation LPA EPHB2 15494214 1354849 *Activation* of by phenylephrine and [LPA] occurs in a dose- and time dependent manner . Positive_regulation LPA EPHB2 15494214 1354856 The data indicate that ERK activation is essential for phenylephrine stimulation of NHE1 , and that and RhoA are *involved* in [LPA] stimulation of NHE1 by more than one mechanism . Positive_regulation LPA EPHB2 15494214 1354869 These studies indicate a direct involvement of ERK in the alpha ( 1 ) -adrenergic activation of NHE1 and a significant *role* for both and RhoA in [LPA] stimulation of NHE1 in CCL39 fibroblasts . Positive_regulation LPA EPHB2 18027882 1894635 [LPA] *induced* activation of through pertussis toxin-sensitive manner , and pretreatment of MSCs with U0126 , a MEK inhibitor , or pertussis toxin attenuated the LPA induced migration . Positive_regulation LPA EPHB2 19077254 2003177 [LPA] and S1P also *induce* p44/42 MAP kinase phosphorylation in these cells and stimulate cell proliferation via G i/o coupled receptors in an Epidermal Growth Factor Receptor (EGFR)- and ERK dependent pathway . Positive_regulation LPA EPHB2 21244430 2397888 However , the IL-1ß treatment had no appreciable effect on [LPA] ( 1 ) receptor mRNA expression and LPA induced *activation* of , Akt , and proliferation . Positive_regulation LPA EPHB2 21890597 2506404 LPA stimulated p21 via [LPA] ( 1 ) and LPA ( 2 ) receptors and dependent *activation* of the CCAAT/enhancer binding protein beta transcription factor independent of p53 . Positive_regulation LPA EPHB2 22314276 2571465 SPK1 mediated activation of the PI3K-AKT-ß-catenin pathway is essential for ATX induction , while SPK1 mediated activation is *required* for [LPA] ( 3 ) up-regulation . Positive_regulation LPA EPHB2 23942151 2840841 [LPA] *induced* phosphorylation of and p38 MAP kinase in R182 cells and pretreatment of cells with the MEK-ERK pathway inhibitor U0126 , but not the p38 MAPK inhibitor SB202190 , resulted in abrogation of LPA induced cell migration . Positive_regulation LPA F2R 21093894 2376977 Furthermore , MMP-1 and were both significantly *induced* by [LPA] ( 20 µM ) , and siRNA silencing of MMP-1 and PAR1 both significantly reduced LPA 's invasion promoting effect in DOV13 cells ( p < 0.05 ) . Positive_regulation LPA F3 7240413 15670 Very low density [lipoprotein] *induced* a maximal 6.7-fold increase in the expression of a activity , which was consistent with tissue factor , in that it was dependent on Factors VII , X , and II . Positive_regulation LPA FAS 12235183 988980 These studies demonstrate that unsaturated drive the esterification reaction and *enhance* [lipoprotein] cholesterol secretion by the liver under conditions where cholesterol balance across this organ is constant . Positive_regulation LPA FAS 15661236 1365063 Our studies suggest that [LPA] *induces* translocation of from the cell membrane to the cytosol , which may provide a mechanism by which ovarian cancer cells evade FasL bearing immune cells . Positive_regulation LPA G0S2 23951308 2831723 Hepatic overexpression *resulted* in an increase in plasma Low-density lipoprotein (LDL)/Very-Low-density ( VLDL ) [lipoprotein] cholesterol level . Positive_regulation LPA GLP1R 19957161 2204072 The is *essential* for postprandial [lipoprotein] synthesis and secretion in hamsters and mice . Positive_regulation LPA GPR115 24504738 2923827 Endothelial barrier function was restored by pharmacological or genetic inhibition of either LPA production by the circulating lysophospholipase D autotaxin or of *dependent* [LPA] signaling . Positive_regulation LPA GPR132 24504738 2923816 Endothelial barrier function was restored by pharmacological or genetic inhibition of either LPA production by the circulating lysophospholipase D autotaxin or of *dependent* [LPA] signaling . Positive_regulation LPA GPR87 24504738 2923896 Endothelial barrier function was restored by pharmacological or genetic inhibition of either LPA production by the circulating lysophospholipase D autotaxin or of *dependent* [LPA] signaling . Positive_regulation LPA HBEGF 10354366 617794 Similar transfection with Edg-3 plus -5 antisense plasmids suppressed Tsup-1 cell levels of immunoreactive Edg-3 and -5 , but not Edg-2 or -4 , and concurrently reduced S1P- , but not [LPA-] , *induced* Tsup-1 cell increases in both and susceptibility to DT . Positive_regulation LPA HBEGF 15149861 1248434 We established that mouse blastocysts indeed express HB-EGF and that [LPA] *induces* the transient accumulation of on the embryo surface , which was blocked by treatment with either BAPTA-AM or the protein trafficking inhibitor , brefeldin A . Positive_regulation LPA HBEGF 15313912 1285688 [LPA] , which is constitutively produced by ovarian cancer cells , *induced* ectodomain shedding in SKOV3 and RMG-1 cells , resulting in the transactivation of EGFR and the downstream kinase extracellular signal regulated kinase/mitogen activated protein kinase . Positive_regulation LPA IL1B 16087165 1443237 Very low-density [lipoprotein] *induces* expression in macrophages . Positive_regulation LPA IL1B 8006515 258094 Nitrone spin trap lipophilicity as a determinant for inhibition of low density [lipoprotein] oxidation and *activation* of release from human monocytes . Positive_regulation LPA LBP 1883513 165627 Compared to *induction* of TNF-alpha , [LPS-lipoprotein] complexes are as much as 10,000-fold less active . Positive_regulation LPA LIPG 17822686 1817467 *enhances* low density [lipoprotein] binding and cell association in THP-1 macrophages . Positive_regulation LPA LIPG 22972429 2706277 *regulates* plasma high-density [lipoprotein-cholesterol] ( HDL-C ) levels by promoting HDL catabolism . Positive_regulation LPA MAP2K6 9889195 585344 [LPA] also *induced* the activation of , but not that of RAF1 , in CHO-DeltaSOS cells . Positive_regulation LPA MIP 21464938 2412918 LPA5 is a bona fide [LPA] receptor on human mast cells responsible for the majority of LPA *induced* release . Positive_regulation LPA MMP7 17114341 1651370 In addition , [LPA] apparently *induced* the activation of in DOV13 cells as detected by gelatin zymography . Positive_regulation LPA MUC16 15485666 1320717 Nontypeable Haemophilus influenzae [lipoprotein] P6 *induces* MUC5AC transcription via TLR2-TAK1 dependent p38 MAPK-AP1 and IKKbeta-IkappaBalpha-NF-kappaB signaling pathways . Positive_regulation LPA PCSK9 23115612 2695873 The *role* of in the regulation of circulating low density [lipoprotein-cholesterol] ( LDL-c ) levels is ascribed to binding of circulating PCSK9 to the LDL receptor (LDLR) and subsequent lysosomal degradation of LDLR . Positive_regulation LPA PCSK9 24509273 2928469 Inhibition of with evolocumab *resulted* in significant dose related reductions in [Lp(a)] . Positive_regulation LPA PLAT 12080650 581438 Plasma [Lp (a)] concentration and *activation* of and plasminogen activator inhibitor-1(PAI-1) were determined in 50 patients with chronic renal failure (CRF) and in 50 healthy subjects . Positive_regulation LPA PLAT 2142106 135746 We confirmed recent reports that [Lp(a)] is not *activated* by streptokinase or to yield plasmin-like activity . Positive_regulation LPA PLAU 10589790 572231 Because LPA stimulates the invasion of both hepatoma and lung cell lines , we investigated whether [LPA] could *induce* secretion by ovarian epithelial cells and whether this process was associated with malignant transformation of ovarian epithelial cells . Positive_regulation LPA PLAU 10589790 572236 [LPA] *induced* a consistent increase in promoter activity and mRNA levels , suggesting that increased uPA production is , at least in part , transcriptional . Positive_regulation LPA PLAU 10818454 693942 [LPA] *increases* cell proliferation , cell survival , resistance to cisplatin , cell shrinkage , and production of vascular endothelial growth factor , , and LPA itself in ovarian cancer cells , but not in normal ovarian surface epithelial cells . Positive_regulation LPA PLAU 17611702 1768697 Finally , [LPA] *induces* secretion from ovarian cancer cells predominantly through the LPA2 receptor , with LPA3 contributing to this process . Positive_regulation LPA PLAU 22249252 2674870 [LPA] *induced* matrix metalloproteinase (MMP)-9 expression in CAOV-3 and PA-1 cells and ( uPA ) expression in SKOV-3 cells . Positive_regulation LPA S1PR3 10354366 617796 Similar transfection with Edg-3 plus -5 antisense plasmids suppressed Tsup-1 cell levels of immunoreactive and -5 , but not Edg-2 or -4 , and concurrently reduced S1P- , but not [LPA-] , *induced* Tsup-1 cell increases in both HB-EGF and susceptibility to DT . Positive_regulation LPA TGM2 12763041 1093835 We have investigated the novel function of intracellular reactive oxygen species ( ROS ) in the *activation* of in situ by [lysophosphatidic acid (LPA)] and transforming growth factor-beta ( TGF-beta ) in Swiss 3T3 fibroblasts . Positive_regulation LPA TNF 15319868 1286503 The 19-kDa [lipoprotein] proapoptotic signal was *mediated* by Toll-like receptor 2 but not by . Positive_regulation LPA TNF 19154986 2027111 The Mtb 19 kDa [lipoprotein] *induced* release of in a manner dependent on both TLR2 and RP105 , and macrophage activation by Mtb lacking mature lipoproteins was not RP105 dependent . Positive_regulation LPA TNF 22493518 2595543 ATX expression from SFs was induced by , and [LPA] *induced* SF activation and effector functions in synergy with TNF . Positive_regulation LPA TNF 8387950 218076 *stimulated* enhancement of low-density [lipoprotein] binding occurred at all stages of cell growth . Positive_regulation LPA TNF 8387950 218078 Competition experiments using unlabeled low-density lipoprotein and blockage experiments with a monoclonal low-density lipoprotein receptor antibody showed that *stimulated* low-density [lipoprotein] binding takes place through stimulation of low-density lipoprotein receptors . Positive_regulation LPA TNF 9840652 552789 In vitro studies with cultured human skin fibroblasts , human umbilical vein endothelial cells , and HepG2 hepatoma cells showed that *increased* the degradation of 125I labeled low-density [lipoprotein] in all the cell lines tested . Positive_regulation LPA UNC5B 23599441 2783863 Indeed , using promoter-luciferase reporter genes , we show that Ntn1- and activities are *induced* by oxidized low-density [lipoprotein] and require HIF-1a . Positive_regulation LPAR1 HBEGF 10354366 617786 Similar transfection with Edg-3 plus -5 antisense plasmids suppressed Tsup-1 cell levels of immunoreactive Edg-3 and -5 , but not [Edg-2] or -4 , and concurrently reduced S1P- , but not LPA- , *induced* Tsup-1 cell increases in both and susceptibility to DT . Positive_regulation LPAR1 TNF 21521824 2439749 *promotes* [LPA1-] and LPA3 mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines . Positive_regulation LPAR2 PLAU 17611702 1768696 Finally , LPA *induces* secretion from ovarian cancer cells predominantly through the [LPA2] receptor , with LPA3 contributing to this process . Positive_regulation LPCAT1 CA2 8906554 394232 The elevation of intracellular levels in postsynaptic neurons , an essential step in the induction of LTP in the hippocampus , can *lead* to activation of the enzyme [acetyl-CoA:lyso-PAF acetyltransferase] that is required for PAF synthesis in neurons . Positive_regulation LPCAT2 TNF 22290395 2617481 Furthermore , and transforming growth factor-ß1 *induced* the expression of [Lpcat2/4] and Abcc1/4 and down-regulated Slc10a1 and Slco1a1 in primary hepatocytes , suggesting an association between the changes in serum LPC and bile acids and proinflammatory cytokines . Positive_regulation LPCAT4 TNF 22290395 2617482 Furthermore , and transforming growth factor-ß1 *induced* the expression of [Lpcat2/4] and Abcc1/4 and down-regulated Slc10a1 and Slco1a1 in primary hepatocytes , suggesting an association between the changes in serum LPC and bile acids and proinflammatory cytokines . Positive_regulation LPIN1 IL1B 18940942 1994814 Importantly , the LPS induced decrease in lipin-1 mRNA levels was significantly but not totally blunted in TNF-alpha/IL-1 receptor-null mice compared with controls , suggesting key *roles* for and other cytokines in mediating LPS induced repression of [lipin-1] . Positive_regulation LPIN1 PGC 21549711 2435368 , ERRa , or ERR? overexpression *increased* [Lpin1] transcription in cultured ventricular myocytes and the ERRs were associated with response elements in the first intron of the Lpin1 gene . Positive_regulation LPIN1 PGC 21549711 2435369 Concomitant RNAi mediated knockdown of ERRa and ERR? abrogated the *induction* of [lipin 1] expression by overexpression . Positive_regulation LPIN1 TNF 18940942 1994813 Importantly , the LPS induced decrease in lipin-1 mRNA levels was significantly but not totally blunted in TNF-alpha/IL-1 receptor-null mice compared with controls , suggesting key *roles* for and other cytokines in mediating LPS induced repression of [lipin-1] . Positive_regulation LPL FAS 11246888 793317 All , with the exception of EPA and OA , *increased* extra- and intracellular [LPL] immunoreactive mass and activity . Positive_regulation LPL FOXO1 12586369 1059064 Ectopic expression of *enhanced* [LPL] gene expression in C2C12 muscle cells in culture . Positive_regulation LPL SORL1 21385844 2404449 *regulates* the activity of [lipoprotein lipase] by intracellular trafficking . Positive_regulation LPL SORL1 21385844 2404452 By analogy , *regulated* the vesicle-like localization of [LPL] in primary neuronal cells . Positive_regulation LPL TNF 11681809 873926 TNF-alpha and IL-6 inhibit [lipoprotein lipase] , and additionally *stimulates* hormone-sensitive lipase and induces uncoupling protein expression . Positive_regulation LPL TNF 20628900 2310246 In the *presence* of , Met and Cys significantly increased the [LPL] activity , and Met also enhanced the LPL mRNA level . Positive_regulation LPL TNF 2111695 132934 *induced* release of endothelial cell [lipoprotein lipase] . Positive_regulation LPL TNF 2575958 124678 3. Inhibition of lipoprotein lipase synthesis in similar experiments in mammals has been attributed to the effects of TNF-alpha and/or IL-1 , but recombinant human and IL-1 *had* no effect on [lipoprotein lipase] activity in chicken adipocytes . Positive_regulation LPL TNF 2917156 107239 It is suggested that the increase in [lipoprotein lipase] activity of heart and diaphragm *resulted* from an indirect effect of . Positive_regulation LPL TNF 3396878 96102 In the liver , *caused* a marked increase in [LPL] mRNA levels , which are normally very low . Positive_regulation LPL TNF 7527452 280744 Overall these data demonstrate that [LPL] *induces* mRNA expression in a PKC dependent manner and that the PKC effect involves transcriptional events as well as posttranscriptional modifications . Positive_regulation LPL TNF 8169531 255043 We further established that [LPL] *induced* the transcription of the gene in macrophages . Positive_regulation LPL TNF 9369379 464024 Nitric oxide mediates down regulation of [lipoprotein lipase] activity *induced* by in brown adipocytes . Positive_regulation LPO HES2 15610895 1357275 We also report here formation of the depurinating 3'-OH-HES-6'-N7Gua and 3'-OH-HES-6'-N3Ade adducts by reaction of HES-3',4'-Q with DNA or by *activation* of <3'-OH-HES> by tyrosinase , [lactoperoxidase] , prostaglandin H synthase or 3-methylcholanthrene induced rat liver microsomes in the presence of DNA . Positive_regulation LPO HES2 20417678 2339423 We observed dramatically increased malonaldehyde ( MDA ) levels after HES , which indicates that *caused* [LPO] through the regulation of oxidative stress and LPO related transcripts , as revealed by microarray . Positive_regulation LPO TNF 17352195 1708505 The synergistic interaction can sharply increase the proapoptotic capacity of each of these factors since *activates* SMase and [LPO] , SMase activity depends on the LPO rate , while ceramide , an SMase produced secondary messenger of apoptosis , can induce oxidative stress . Positive_regulation LPXN FAS 20543562 2360316 Therefore , dynamic [LPXN] tyrosine phosphorylation *requires* translocation to . Positive_regulation LRP1 CTGF 15469966 1342404 CTGF induced tryrosine phosphorylation of the cytoplasmic domain of the low-density lipoprotein receptor associated protein ( LRP ) in fibroblasts , and the LRP-antagonist , receptor associated protein (RAP) inhibited *induced* tryrosine phosphorylation of [LRP] . Positive_regulation LRP1 PLAT 16489109 1589232 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of tPA and inhibit the *mediated* interaction between [LRP] and alphavbeta3 . Positive_regulation LRP1 PLAT 18037995 1832673 In rat kidney fibroblasts , *induced* rapid [LRP-1] tyrosine phosphorylation and enhanced beta1 integrin recruitment by facilitating the LRP-1/beta1 integrin complex formation . Positive_regulation LRP1 PLAT 18037995 1832677 In murine renal interstitium after obstructive injury , tPA and alpha-SMA colocalized with LRP-1 , and deficiency *reduced* [LRP-1/beta1] integrin interaction and myofibroblast activation . Positive_regulation LRP1 PLAT 18037995 1832679 These findings show that *induces* [LRP-1] tyrosine phosphorylation , which in turn facilitates the LRP-1 mediated recruitment of beta1 integrin and downstream ILK signaling , thereby leading to myofibroblast activation . Positive_regulation LRP1 PLAU 9665342 518430 Degradation of in endometrial stromal cells *requires* both the UPA receptor and the low-density lipoprotein receptor related [protein/alpha2-macroglobulin receptor] . Positive_regulation LRP1 TNF 22298529 2546361 These studies indicate that and IL-1ß *regulate* [LRP-1] in PMCs and that LRP-1 thereby contributes to a range of pathophysiologically relevant responses of these cells . Positive_regulation LRP10 CTGF 15469966 1342401 CTGF induced tryrosine phosphorylation of the cytoplasmic domain of the low-density lipoprotein receptor associated protein ( LRP ) in fibroblasts , and the LRP-antagonist , receptor associated protein (RAP) inhibited *induced* tryrosine phosphorylation of [LRP] . Positive_regulation LRP10 PLAT 16489109 1589229 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of tPA and inhibit the *mediated* interaction between [LRP] and alphavbeta3 . Positive_regulation LRP11 CTGF 15469966 1342402 CTGF induced tryrosine phosphorylation of the cytoplasmic domain of the low-density lipoprotein receptor associated protein ( LRP ) in fibroblasts , and the LRP-antagonist , receptor associated protein (RAP) inhibited *induced* tryrosine phosphorylation of [LRP] . Positive_regulation LRP11 PLAT 16489109 1589230 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of tPA and inhibit the *mediated* interaction between [LRP] and alphavbeta3 . Positive_regulation LRP12 CTGF 15469966 1342403 CTGF induced tryrosine phosphorylation of the cytoplasmic domain of the low-density lipoprotein receptor associated protein ( LRP ) in fibroblasts , and the LRP-antagonist , receptor associated protein (RAP) inhibited *induced* tryrosine phosphorylation of [LRP] . Positive_regulation LRP12 PLAT 16489109 1589231 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of tPA and inhibit the *mediated* interaction between [LRP] and alphavbeta3 . Positive_regulation LRP2 CLU 18321852 1904425 Indeed overexpression *up-regulated* the expression of [megalin] and induced its phosphorylation in a dose dependent manner . Positive_regulation LRP2 CTGF 15469966 1342405 CTGF induced tryrosine phosphorylation of the cytoplasmic domain of the low-density lipoprotein receptor associated protein ( LRP ) in fibroblasts , and the LRP-antagonist , receptor associated protein (RAP) inhibited *induced* tryrosine phosphorylation of [LRP] . Positive_regulation LRP2 PLAT 16489109 1589233 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of tPA and inhibit the *mediated* interaction between [LRP] and alphavbeta3 . Positive_regulation LRP2 TNF 21371423 2411527 mRNA expression was increased by LPS treatment , and knockdown of the mRNA with siRNA *inhibited* LPS mediated downregulation of [megalin] mRNA expression at the 24-h time point . Positive_regulation LRP3 CTGF 15469966 1342406 CTGF induced tryrosine phosphorylation of the cytoplasmic domain of the low-density lipoprotein receptor associated protein ( LRP ) in fibroblasts , and the LRP-antagonist , receptor associated protein (RAP) inhibited *induced* tryrosine phosphorylation of [LRP] . Positive_regulation LRP3 PLAT 16489109 1589234 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of tPA and inhibit the *mediated* interaction between [LRP] and alphavbeta3 . Positive_regulation LRP4 CTGF 15469966 1342407 CTGF induced tryrosine phosphorylation of the cytoplasmic domain of the low-density lipoprotein receptor associated protein ( LRP ) in fibroblasts , and the LRP-antagonist , receptor associated protein (RAP) inhibited *induced* tryrosine phosphorylation of [LRP] . Positive_regulation LRP4 PLAT 16489109 1589235 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of tPA and inhibit the *mediated* interaction between [LRP] and alphavbeta3 . Positive_regulation LRP5 CTGF 15469966 1342408 CTGF induced tryrosine phosphorylation of the cytoplasmic domain of the low-density lipoprotein receptor associated protein ( LRP ) in fibroblasts , and the LRP-antagonist , receptor associated protein (RAP) inhibited *induced* tryrosine phosphorylation of [LRP] . Positive_regulation LRP5 IGFBP1 18583428 1946743 Stromal cells were cultured for up to 4 weeks with estradiol ( E ( 2 ) ) and/or medroxy progesterone acetate ( MPA ) in the *presence* or the absence of and , [LR(3)-IGF-I] ( an IGF-I analogue ) that binds to the IGF-I receptor but has reduced affinity for IGFBPs . Positive_regulation LRP5 PLAT 16489109 1589236 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of tPA and inhibit the *mediated* interaction between [LRP] and alphavbeta3 . Positive_regulation LRP6 CTGF 15469966 1342409 CTGF induced tryrosine phosphorylation of the cytoplasmic domain of the low-density lipoprotein receptor associated protein ( LRP ) in fibroblasts , and the LRP-antagonist , receptor associated protein (RAP) inhibited *induced* tryrosine phosphorylation of [LRP] . Positive_regulation LRP6 CTGF 21237163 2386774 *stimulates* phosphorylation of [LRP6] and GSK-3ß resulting in accumulation and nuclear localisation of ß-catenin , TCF/LEF activity and expression of Wnt targets . Positive_regulation LRP6 PLAT 16489109 1589237 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of tPA and inhibit the *mediated* interaction between [LRP] and alphavbeta3 . Positive_regulation LRP8 CTGF 15469966 1342410 CTGF induced tryrosine phosphorylation of the cytoplasmic domain of the low-density lipoprotein receptor associated protein ( LRP ) in fibroblasts , and the LRP-antagonist , receptor associated protein (RAP) inhibited *induced* tryrosine phosphorylation of [LRP] . Positive_regulation LRP8 PLAT 16489109 1589238 PAI-1 and the PAI-1 derived hexapeptide EEIIMD abolish the vasocontractile activity of tPA and inhibit the *mediated* interaction between [LRP] and alphavbeta3 . Positive_regulation LRPAP1 IL1B 22572995 2638064 Collectively , the results indicated that *regulates* expression of IL1R1 and [IL1RAP] and stimulates expression of PTGS1 and PTGS2 that are considered to be the most rate limiting enzymes for endometrial synthesis of PGs during the peri-implantation period of pregnancy in pigs . Positive_regulation LRPPRC EDN2 19330911 2052609 Here , we investigate whether serum soluble gp130 concentrations correlate with blood pressure in humans , whether gp130 expression in the aorta differs between hypertensive and control rats , and whether angiotensin II or *regulate* [gp130] expression in human VSMC . Positive_regulation LRPPRC FAS 18593565 1953614 induced caspase activation *leads* to degradation of [gp130] , thereby suppressing IL-6 induced phosphorylation of STAT3 ( Tyr ( 705 ) ) and of tyrosine phosphatase SHP2 ( Tyr ( 580 ) ) . Positive_regulation LRPPRC GPR115 20226789 2265734 Stimulation of results in uniform cell enlargement in all directions with an increase in skeletal alpha-actin ( alpha-SKA ) gene expression , while stimulation of [gp130] receptor by interleukin-6 (IL-6) related cytokines *induces* longitudinal elongation with no increase in alpha-SKA gene expression . Positive_regulation LRPPRC GPR132 20226789 2265723 Stimulation of results in uniform cell enlargement in all directions with an increase in skeletal alpha-actin ( alpha-SKA ) gene expression , while stimulation of [gp130] receptor by interleukin-6 (IL-6) related cytokines *induces* longitudinal elongation with no increase in alpha-SKA gene expression . Positive_regulation LRPPRC GPR87 20226789 2265803 Stimulation of results in uniform cell enlargement in all directions with an increase in skeletal alpha-actin ( alpha-SKA ) gene expression , while stimulation of [gp130] receptor by interleukin-6 (IL-6) related cytokines *induces* longitudinal elongation with no increase in alpha-SKA gene expression . Positive_regulation LRPPRC IL1B 9326296 457099 These results demonstrate that expression of the genes encoding IL-6 , IL-6R , and [gp130] can be up-regulated in selective regions of the brain in *response* to the bacterial endotoxin LPS and the proinflammatory cytokine ( only for IL-6R expression ) . Positive_regulation LRPPRC PPBP 18707017 2020378 *Induction* of differentially expressed chemokines CXCL1-3 , CXCL5 , and CXCL6 as well as LIF and [gp130] in MSC by was verified by real-time polymerase chain reaction . Positive_regulation LRPPRC TNF 12817006 1103563 In this study we demonstrate that stimulation of macrophages and fibroblast cell lines with causes the recruitment of SHP2 to the gp130 signal transducing subunit and *leads* to tyrosine phosphorylation of SHP2 and [gp130] . Positive_regulation LRPPRC TNF 21862654 2486520 Among inflammatory cytokine related genes , blockade *reduced* expression of interleukin (IL)-1 receptor type 2 , interferon-? receptors , IL6 , IL6 receptor , [gp130] , and IL17 receptors . Positive_regulation LRRC31 GPHA2 15890769 1426688 Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly [leucine-rich repeat containing] G protein coupled receptor-1 ( DLGR1 ) and *stimulation* of human thyrotropin receptors by chimeric fly and human GPB5 . Positive_regulation LRRC31 GPHB5 15890769 1426689 Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly [leucine-rich repeat containing] G protein coupled receptor-1 ( DLGR1 ) and *stimulation* of human thyrotropin receptors by chimeric fly GPA2 and human . Positive_regulation LRRC31 STAT3 24455684 2884461 *upregulates* [leucine-rich repeat containing] g protein coupled receptor 4 expression in osteosarcoma cells . Positive_regulation LRRC55 GPHA2 15890769 1426726 Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly [leucine-rich repeat containing] G protein coupled receptor-1 ( DLGR1 ) and *stimulation* of human thyrotropin receptors by chimeric fly and human GPB5 . Positive_regulation LRRC55 GPHB5 15890769 1426727 Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly [leucine-rich repeat containing] G protein coupled receptor-1 ( DLGR1 ) and *stimulation* of human thyrotropin receptors by chimeric fly GPA2 and human . Positive_regulation LRRC55 STAT3 24455684 2884480 *upregulates* [leucine-rich repeat containing] g protein coupled receptor 4 expression in osteosarcoma cells . Positive_regulation LRRC59 MAP2K6 11466212 839762 Inhibition of phosphatidylinositol 3-kinase or *leads* to suppression of [p34] ( cdc2 ) kinase activity and meiotic progression beyond the meiosis I stage in porcine oocytes surrounded with cumulus cells . Positive_regulation LRRK2 FOXO1 20624856 2316445 *Activation* of by [LRRK2] induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila . Positive_regulation LRRK2 MAP2K6 20067578 2241601 binds and *regulates* expression of Parkinson 's disease related protein [LRRK2] . Positive_regulation LRRK2 MAP2K6 20067578 2241603 The increased expression of [LRRK2] and MKK6 *requires* activity . Positive_regulation LTA BPI 8985203 409075 FMLP , serum treated zymosan (STZ) , and [lipoteichoic acid (LTA)] also *induced* release . Positive_regulation LTA CD14 18458151 1927015 Expression of markedly *enhanced* [LTA] binding to the plasma membrane and also enhanced NF-kappaB activation . Positive_regulation LTA CD14 20713893 2312962 In contrast to human blood cells , TLR2 transfected human embryonic kidney 293 cells could be activated only by wt-LTA , whereas activation of these cells by [Deltalgt-LTA] *required* the additional expression of TLR6 and , suggesting that activation of human embryonic kidney 293 cells expressing solely TLR2 is probably mediated by residual lipoproteins in wt-LTA . Positive_regulation LTA IL1B 8638287 342970 IL-2 , IL-6 , IL-8 , TNF-alpha , [TNF-beta] and IFN-gamma , but not IL-1 alpha , were *detected* in the monkey using human reagents . Positive_regulation LTA TLR7 22235849 2591919 ligands , MALP2 , Pam3CSK4 , [LTA] , and imiquimod induced high epithelial COX-2 expression , while zymosan and poly dI : dC *induced* very low enzyme expression . Positive_regulation LTA TNF 10858210 704663 Both PepG and [LTA] *induced* transient increases in and IL-10 in plasma , with peak values at 6 and 12 h , respectively . Positive_regulation LTA TNF 11828371 909621 All [LTA] *induced* the release of , IL-1beta , IL-6 and IL-10 in human whole blood . Positive_regulation LTA TNF 12906718 1121866 PepG and [LTA] , as well as live S. aureus , *induced* the production of and IL-6 in Kupffer cells from both species in a time- and dose dependent manner . Positive_regulation LTA TNF 16783405 1599407 In contrast , S. aureus ( TLR2/TLR1/TLR6 ) or Pam ( 3 ) CSK4 ( TLR2/TLR1 ) , or FSL-1 and [LTA] ( TLR2/TLR6 ) *induced* without an effect on NO. 3 . Positive_regulation LTA TNF 17420241 1742261 [LTA] purified from the bacteria *induced* and IL-6 production from wild-type DCs but not from TLR2 knockout DCs , and the mutant LTA induced a significantly smaller amount of these two cytokines . Positive_regulation LTA TNF 3261303 96033 Whereas whole Gram positive bacteria had no stimulatory effect on monocytes , [LTA] *induced* IL-1 and production at a concentration range equivalent to that of the LPS . Positive_regulation LTA TNF 3279996 90707 No other cellular components , such as cell wall peptidoglycan , group-specific C-carbohydrate or type-specific M protein , suppressed the growth of Meth A . [LTA] , but not the other cellular components , *induced* in Propionibacterium acnes primed mice . Positive_regulation LTA TNF 3805716 70596 To identify the mechanism of action of these agents , we compared bone resorption by isolated osteoclasts with bone resorption by osteoclasts cocultured with osteoblastic cells , and with bone resorption by osteoclasts incubated with supernatants from osteoblastic cells , in the *presence* and absence of recombinant and [TNF-beta] . Positive_regulation LTA TNF 8945544 400317 III-PS , GB-PS , [LTA] , and PG each *induced* in a time- and concentration dependent manner . Positive_regulation LTA TNF 9551921 499058 The TSST1 N-terminal domain ( TSST ( 1-87 ) ) did not induce proliferation of human PBLs or release of [TNF-beta] , but did *induce* release . Positive_regulation LTB ALOX5 10877525 708907 [LTB4] production is *initiated* by the enzyme <5-lipoxygenase (5-LOX)> . Positive_regulation LTB ALOX5 1314503 184999 To determine whether [LTB4] release by human alveolar macrophages following A23187 stimulation *required* the de novo production of <5-lipoxygenase> , alveolar macrophages were stimulated under conditions that would preclude a role for new enzyme production . Positive_regulation LTB ALOX5 1318548 188005 Furthermore , the <5-lipoxygenase> inhibitors BWA4C , an acetohydroxyamic acid , and BW755C , a phenyl pyrazoline , can readily *inhibit* [LTB4] synthesis in canine PMNs . Positive_regulation LTB ALOX5 1320811 190148 We used a specific 5-lipoxygenase inhibitor , A-63162 , to examine the *role* of <5-lipoxygenase (5-LO)> in equine blood mononuclear cell ( BMC ) proliferation and [leukotriene B4 (LTB4)] synthesis after stimulation with mitogen ( phytohemagglutinin , PHA ) or calcium ionophore ( A23187 ) . Positive_regulation LTB ALOX5 15887113 1407051 Inhibition of the LTB4 biosynthetic enzyme <5-lipoxygenase> *inhibited* toxin A-induced increases in ileal [LTB4] levels and toxin A- but not LTB4 induced ileitis . Positive_regulation LTB ALOX5 1664445 175184 The <5-lipoxygenase> inhibitors *reduced* the PMN infiltration as well as [LTB4] release into aqueous humor . Positive_regulation LTB ALOX5 16733792 1496683 The synthesis of the leukotriene [LTB] ( 4 ) is *initiated* by the enzyme <5-lipoxygenase> and completed by LTA(4) hydrolase . Positive_regulation LTB ALOX5 1846160 151544 2 ) <5-LO> translocation , which may occur independently of increased intracellular Ca2+ , may be *necessary* for [LTB4] generation but is insufficient for its release . Positive_regulation LTB ALOX5 20863006 2325999 A set of 25 derivatives of 3- [ 1- ( 6-substituted-pyridazin-3-yl ) -5- ( 4-substituted-phenyl ) -1H-pyrazol-3-yl ] propanoic acids has been synthesized and evaluated for their in vitro cyclooxygenase-1/2 ( COX-1/ 2 ) inhibitory activity using assays with purified COX-1 and COX-2 enzymes as well as for their <5-lipoxygenase (5-LO)> *mediated* [LTB4] formation inhibitory activity using an assay with activated human polymorphonuclear leukocytes ( PMNL ) . Positive_regulation LTB ALOX5 2545780 114320 Inhibition of <5-lipoxygenase> by nordihydro-guaiaretic acid or AA-861 *blocked* the PAF induced augmentation of both TNF and [LTB4] production . Positive_regulation LTB ALOX5 2559032 123400 The <5-lipoxygenase> inhibitors , SK & F 86002 , SK & F 104493 , and phenidone *inhibited* [LTB4] production in vivo as well as inflammatory cell infiltration induced by arachidonic acid . Positive_regulation LTB ALOX5 3929783 52273 Two well-known inhibitors of <5-lipoxygenase> , nordihydroguaiaretic acid and phenidone , *blocked* [LTB4] synthesis without affecting ATP production . Positive_regulation LTB ALOX5 7701249 297537 LTB4 omega-hydroxylase activity is an important factor in regulating LTB4 level in colonic mucosa , and the increased [LTB4] level in inflamed mucosa with IBD , especially ulcerative colitis , is *caused* by decreased LTB4 omega-hydroxylase activity and increased <5-lipoxygenase> activity . Positive_regulation LTB ALOX5 7840141 293810 The lack of PLA2 activation in Thap stimulated neutrophils results from the inhibition of [LTB4] formation in the *presence* of <5-LO> inhibitors . Positive_regulation LTB ALOX5 8299991 248604 As with other antioxidant compounds , several of the chalcogenides were relatively selective inhibitors of monocyte <5'-lipoxygenase> *dependent* secretion of [LTB4] as compared to their effect on cyclooxygenase dependent secretion of PGE2 ( for example compound 42 had IC50s of 0.6 microM and 10 microM , respectively ) . Positive_regulation LTB EPHB2 16005851 1434976 sPLA ( 2 ) -IB also stimulated mitogen activated protein kinase , but its activity was not *required* for [LTB4] production . Positive_regulation LTB IL1B 11445585 860068 Hence , lambda/iotaPKC regulates snpPLA ( 2 ) [/LTB] ( 4 ) -mediated cPLA(2) activation , cellular arachidonic acid release , and NF-kappaB activation *induced* by TNF-alpha and . Positive_regulation LTB IL1B 15910501 1411996 Hepatic expression of the tumor necrosis factor family member [lymphotoxin-beta] is *regulated* by interleukin (IL)-6 and : transcriptional control mechanisms in oval cells and hepatoma cell lines . Positive_regulation LTB IL1B 17068631 1637599 To investigate quantification of expression of [LTB4] *inducing* and TNF-alpha at mRNA level in synovial membrane cells of rheumatoid arthritis . Positive_regulation LTB IL1B 17068631 1637605 [LTB4] of synovial membrance cells in rheumatoid arthritis could *induce* expressions of TNF-alpha and at mRNA level , and their expression at mRNA level had been quantified successfully . Positive_regulation LTB IL1B 18472956 290000 However , neither TNFalpha nor *induced* a significant [LTB] ( 4 ) production in SMC alone or AM alone after 24 h of incubation . Positive_regulation LTB IL1B 9777883 540270 In conclusion , beta2-agonists exhibited only minor effects on IL-1beta secretion from blood monocytes and no effect on [LTB4-secretion] from either cell type , and budesonide effectively *inhibited* the release in blood monocytes , but not in alveolar macrophages . Positive_regulation LTB ITGB2 1677155 163239 The data indicate that Tx-induced diapedesis is mediated by the generation of [LTB4] and the *activation* of neutrophil but not endothelial adhesion proteins . Positive_regulation LTB TNF 10101740 560904 Moreover , the *induced* stimulation of [LTB4] release that we demonstrated in PMN-HAEC interaction was also inhibited by loratadine . Positive_regulation LTB TNF 11445585 860067 Hence , lambda/iotaPKC regulates snpPLA ( 2 ) [/LTB] ( 4 ) -mediated cPLA(2) activation , cellular arachidonic acid release , and NF-kappaB activation *induced* by and IL-1beta . Positive_regulation LTB TNF 12117933 964677 [LTB] ( 4 ) also *induced* significant production , and blockade of TNF-alpha suppressed LTB ( 4 ) -induced NO release and parasite killing . Positive_regulation LTB TNF 15034048 1223608 and phorbol esters *induce* [lymphotoxin-beta] expression through distinct pathways involving Ets and NF-kappa B family members . Positive_regulation LTB TNF 15034048 1223613 Interestingly , the same mutation had little effect on the ability of to *induce* transcription of the [LT-beta] promoter . Positive_regulation LTB TNF 17068631 1637598 To investigate quantification of expression of [LTB4] *inducing* IL-1beta and at mRNA level in synovial membrane cells of rheumatoid arthritis . Positive_regulation LTB TNF 17068631 1637604 [LTB4] of synovial membrance cells in rheumatoid arthritis could *induce* expressions of and IL-1beta at mRNA level , and their expression at mRNA level had been quantified successfully . Positive_regulation LTB TNF 18472956 289999 However , neither nor IL-1beta *induced* a significant [LTB] ( 4 ) production in SMC alone or AM alone after 24 h of incubation . Positive_regulation LTB TNF 24736410 2949964 Conversely , cathelicidin-deficient ( Cnlp ( -/- ) ) mice produce much less [LTB4] and TXB2 in vivo in *response* to compared with control mice . Positive_regulation LTB TNF 7644564 318764 However , IL-3 or IL-5 lacked this effect when stimulated with exogenous arachidonic acid A at 10 ( -4 ) M . and TGF-alpha *had* no priming effect on [LTB4] synthesis following stimulation with either A23187 ( 5x10 ( -9 ) M ) or AA ( 10 ( -4 ) M ) . Positive_regulation LTB TNF 9561806 500531 Bone marrow stromal cells release PGE2 and [LTB4] in *response* to phorbol myristic acetate ( PMA ) ( 1 microM ) and ( 10 ng/ml ) . Positive_regulation LTBP1 TGM2 9060478 417760 However , only antibodies to the amino-terminal region of LTBP-1 block *dependent* cross linking of large latent complex or [LTBP-1] . Positive_regulation LTF EDN2 8476633 218522 In mucosal explant cultures , ET-1 and *stimulated* [lactoferrin] and mucous glycoprotein release from serous and mucous cells , but ET-3 was inactive . Positive_regulation LTF EPHB2 18521934 1958861 An Aplysia Trk-like receptor ( ApTrkl ) was previously shown to be involved in cell wide [long-term facilitation (LTF)] and *activation* of when serotonin ( 5-HT ) is applied to the cell soma . Positive_regulation LTF MAP2K6 11559949 862507 Forced expression of activated *resulted* in a three- to five-fold decrease in differentiated , [lactoferrin] containing neutrophilic cells resultant from G-CSF induction , and a commensurate increase in cell proliferation . Positive_regulation LTF TF 24376607 2882139 level in serum and tumor necrosis factor-a level in CSF decreased , and the levels of iron , transferrin , [lactoferrin] and prostaglandin E2 in CSF *increased* in PD patients with SD compared with those without SD . Positive_regulation LTF TNF 10580998 570182 [Lactoferrin] itself did not *induce* either production or nitric oxide production , but lipopolysaccharide stimulated tumor necrosis factor-alpha production of macrophages and monocytes were inhibited by lactoferrin treatment combined with stimulant . Positive_regulation LTF TNF 1979172 145135 In the present work we show with a single-cell technique that preincubation of human neutrophils with antibodies to CD18 , the common beta chain of leukocyte adhesion proteins , inhibits *induced* secretion of [lactoferrin] in a time- and concentration dependent manner . Positive_regulation LTF TNF 2117610 139816 In addition , when the cells were incubated at 37 degrees C for 3 h there was a parallel decline in the spontaneous oscillatory activity of cytosolic free [Ca2+ ] and *induced* secretion of [lactoferrin] . Positive_regulation LTF TNF 2670752 117703 *induced* [lactoferrin] release was enhanced by cytochalasin B pretreatment of the granulocytes , while GCP/IL-8 promoted degranulation was not . Positive_regulation LTF TNF 9916742 587529 Human PMN incubated on fibrinogen released [lactoferrin] in *response* to and this response was inhibited by PP1 , a Src family tyrosine kinase inhibitor . Positive_regulation LTF TNF 9916742 587531 Double knockout hck-/- fgr-/- PMN adherent to collagen or fibrinogen failed to release [lactoferrin] in *response* to but responded to PMA as wild-type PMN . Positive_regulation LUM IL1B 22073367 2504486 Expression of [lumican] and fibromodulin *following* stimulation of disc cells of the human temporomandibular joint . Positive_regulation LY6E TNF 1717166 166670 Multiple cytokine interactions regulate Ly-6E antigen expression : cooperative [Ly-6E] *induction* by IFNs , , and IL-1 in a T cell lymphoma and in its induction-deficient variants . Positive_regulation LY75 FAS 12717632 1083901 We investigated the involvement of cytokines , of *induced* apoptosis , and of cytotoxic T [lymphocyte antigen] 4 ( CTLA-4 ) engagement , in the mediation of this phenomenon . Positive_regulation LY75 TLR7 19650904 2125519 Although DNA prime adenoviral vector boost immunizations belong to the strongest inducers of cytotoxic T cell responses in different animal models and humans , the CD8+ T cell responses can be further improved by targeting the DNA encoded antigen to [DEC205] in the *presence* of synergistic ligands CpG and Poly I : Positive_regulation LY75 TLR7 21413003 2404913 We observed that mediated signaling *increases* [DEC-205] expression levels without affecting receptor internalization . Positive_regulation LY86 FAS 12717632 1083899 We investigated the involvement of cytokines , of *induced* apoptosis , and of cytotoxic T [lymphocyte antigen] 4 ( CTLA-4 ) engagement , in the mediation of this phenomenon . Positive_regulation LY9 FAS 12717632 1083902 We investigated the involvement of cytokines , of *induced* apoptosis , and of cytotoxic T [lymphocyte antigen] 4 ( CTLA-4 ) engagement , in the mediation of this phenomenon . Positive_regulation LY96 CD14 14517279 1147333 greatly *enhances* the formation of [LPS-TLR4-MD-2] complexes , but is not coprecipitated with LPS-TLR4-MD-2 complexes , suggesting a role for CD14 in LPS loading onto TLR4-MD-2 but not in the interaction itself between LPS and TLR4-MD-2 . Positive_regulation LY96 EPHB2 18181766 1903387 Both and JNK are *required* for enhancement of [MD-2] gene expression during differentiation of HL-60 cells . Positive_regulation LY96 FAS 12717632 1083900 We investigated the involvement of cytokines , of *induced* apoptosis , and of cytotoxic T [lymphocyte antigen] 4 ( CTLA-4 ) engagement , in the mediation of this phenomenon . Positive_regulation LYN EPHB2 11443118 850437 Overexpression of [Lyn] *induced* constitutive phosphorylation of CrkL and activation of Erk , whereas that of a Lyn mutant lacking the tyrosine kinase domain attenuated the Epo induced phosphorylation of CrkL and activation of . Positive_regulation LYN TNF 8867673 344818 In fact , only in the presence of Mg2+ , but not in the absence of divalent cations or in the presence of Ca2+ alone , *increased* p58c-fgr and [p53/56lyn] kinase activities ; Positive_regulation LYZ TNF 9008610 410853 Piroxicam also decreased the release of gelatinase and [lysozyme] *induced* by , but not by PMA . Positive_regulation MAA PLAU 11853706 913388 We observed that [BSA-MAA] *induces* the increased secretion of , a key component of the plasmin generating system , and that PKC activation is necessary for this enhanced urokinase-type plasminogen activator secretion . Positive_regulation MAD1L1 STK39 18083840 1837332 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation MADCAM1 TNF 10080539 595658 No significant constitutive nor *induced* expression of [MAdCAM-1] was detected in skeletal muscle , brain , or heart . Positive_regulation MADCAM1 TNF 10080539 595659 In IL-10-deficient ( IL-10 k/o ) mice with no clinical or histological evidence of colitis , constitutive and *induced* expression of [MAdCAM-1] in the intestine , cecum , and colon was not different from those values obtained with healthy wild-type controls . Positive_regulation MADCAM1 TNF 10080539 595660 Taken together , these data demonstrate that *enhances* surface expression of [MAdCAM-1] in intestinal and colonic tissues to the same extent in both wild-type and IL-10 k/o mice with no colonic inflammation , whereas IL-10 k/o mice with active colitis exhibited a profound up-regulation of MAdCAM-1 in the colon . Positive_regulation MADCAM1 TNF 11472325 841438 To examine how agents currently used to treat inflammatory bowel disease affect [MAdCAM-1] : *induced* by in an in vitro model of inflammatory bowel disease . Positive_regulation MADCAM1 TNF 11546645 856531 We used two endothelial lines [ bEND.3 ( brain ) and SVEC ( high endothelium ) ] to study the signal paths that regulate [MAdCAM-1] expression in *response* to using RT-PCR , blotting , adhesion , and immunofluorescence . Positive_regulation MADCAM1 TNF 12003644 1011661 Melatonin reduces *induced* expression of [MAdCAM-1] via inhibition of NF-kappaB . Positive_regulation MADCAM1 TNF 12003644 1011662 We examined how different doses of melatonin reduced endothelial [MAdCAM-1] *induced* by in an in vitro model of lymphatic endothelium . Positive_regulation MADCAM1 TNF 12003644 1011664 [MAdCAM-1] was *induced* by . Positive_regulation MADCAM1 TNF 12388057 1034945 We found that in high endothelial venular cells ( SVEC4-10 ) , multiple inhibitors of CYP450 monooxygenases ( SKF-525a , ketoconazole , troleandomycin , itraconazole ) attenuated *induction* of [MAdCAM-1] , whereas NADPH oxidase inhibition ( PR-39 ) did not . Positive_regulation MADCAM1 TNF 12625840 1066715 IL-10 transfected endothelial cells expressed less than half ( 46 +/- 6.6 % ) of the [MAdCAM-1] *induced* by ( set as 100 % ) in non transfected ( control ) cells . Positive_regulation MADCAM1 TNF 12919942 1157690 activation of HEMEC *resulted* in upregulation of the cell adhesion molecules (CAM) ICAM-1 , VCAM-1 , E-selectin , and [mucosal addressin CAM-1 (MAdCAM-1)] , increased IL-8 production , and enhanced leukocyte binding . Positive_regulation MADCAM1 TNF 14742547 1203430 Furthermore , we show that [MAdCAM-1] can be *induced* on human endothelial cells by and gamma interferon . Positive_regulation MADCAM1 TNF 15001427 1217071 We show in this study that two cytochrome p-450 ( CYP450 ) inhibitors from Citrus paradis ( grapefruit ) , bergamottin , and 6',7'-dihydroxybergamottin ( DHB ) block *stimulated* expression of [MAdCAM-1] in cultured endothelial cells and also reduce alpha ( 4 ) beta ( 7 ) -dependent lymphocyte adhesion . Positive_regulation MADCAM1 TNF 15001427 1217072 Bergamottin ( 20-50 microM ) or DHB ( 10-30 microM ) pretreatment dose-dependently reduced *mediated* expression of [MAdCAM-1] and lymphocyte adhesion . Positive_regulation MADCAM1 TNF 15001427 1217073 SKF-525a , a specific CYP450 inhibitor , also blocked the expression of [MAdCAM-1] *mediated* by . Positive_regulation MADCAM1 TNF 15694007 1376333 We found that troglitazone ( 10-40 microM ) , significantly reduced the ( 1 ng/ml ) mediated *induction* of endothelial [MAdCAM-1] in a dose dependent manner , achieving a 34.7 % to 98.4 % reduction in induced MAdCAM-1 . Positive_regulation MADCAM1 TNF 15735432 1378430 *induced* [MAdCAM-1] in a dose dependent manner by 24 hours . Positive_regulation MADCAM1 TNF 15735432 1378432 In vitro , [MAdCAM-1] can be *induced* on colon endothelial cells by stimulation and may represent a useful model to study microvascular injury in the large intestine . Positive_regulation MADCAM1 TNF 16190815 1462613 SV-LEC also expresses [MAdCAM-1] in *response* to , an effect seen in VEC , but not AEC . Positive_regulation MADCAM1 TNF 19940029 2198783 Blockage of angiotensin II type 1 receptor regulates *induced* [MAdCAM-1] expression via inhibition of NF-kappaB translocation to the nucleus and ameliorates colitis . Positive_regulation MADCAM1 TNF 19940029 2198813 AT1R blocker significantly suppressed [MAdCAM-1] expression *induced* by , but did not inhibit phosphorylation of p38 MAPK or of IkappaB that modulate MAdCAM-1 expression . Positive_regulation MADCAM1 TNF 21225644 2379561 In this study , we show that deamination of methylamine ( MA ) by vascular adhesion protein 1 (VAP-1) [ a semicarbazide-sensitive amine oxidase ( SSAO ) expressed in the human liver ] in the *presence* of a induces the expression of functional [MAdCAM-1] in hepatic endothelial cells and in intact human liver tissue ex vivo . Positive_regulation MADCAM1 TNF 21981016 2547162 We investigated how expression of ICAM-1 , VCAM-1 , [MAdCAM-1] , PECAM-1 , E- and P-selectin in *response* to , IL-1ß and IFN-? was altered by aglycemia ( A ) , hypoxia ( H ) or combined oxygen glucose deprivation ( OGD ) . Positive_regulation MADCAM1 TNF 7724598 302012 Expression of [MAdCAM-1] is *induced* in the murine endothelial cell line bEnd.3 by , interleukin 1 , and bacterial lipopolysaccharide . Positive_regulation MADCAM1 TNF 7724598 302039 These findings establish that , as with other endothelial cell adhesion molecules , transcriptional *induction* of [MAdCAM-1] by requires activated NF-kappa B proteins . Positive_regulation MADCAM1 TNF 9678753 520703 Splenic [MAdCAM-1] expression , follicular dendritic cell localization and normal Peyer 's patch development all *require* both surface LT-alphabeta and activity . Positive_regulation MAF CTGF 16343439 1504085 however , the c-Maf could not induce TGF-beta , nor could TGF-beta induce the c-Maf , suggesting that *activation* of by [Maf] is TGF-beta independent . Positive_regulation MAF ITGB2 3923098 49078 Specifically , [macrophage activating factor (MAF)] , interferon-gamma (IFN-gamma) , or picogram amounts of endotoxin ( LPS ) *induced* on TG-elicited macrophages following overnight incubation . Positive_regulation MAF MIP 17262012 1691334 Misexpression of L-Maf and [c-Maf] *induces* ectopic expression of Cx43 and ; Positive_regulation MAF TNF 2150351 149370 Although calcium ionophore A23187 and [macrophage activating factor (MAF)] ( both can activate M phi to mediate tumoricidal activity ) did not *induce* mRNA expression by themselves , they did act synergistically with LPS . Positive_regulation MAFA FOXO1 16154098 1455455 We show that hyperglycemia suppresses MafA expression in vivo and that [MafA] inhibition can be *prevented* by transgenic expression of constitutively nuclear in beta cells . Positive_regulation MAFB EPHB2 15121870 1242202 [MafB/Kreisler] is induced in *response* to and synergizes with GATA and Ets to enhance transcription from the proximal promoter . Positive_regulation MAFB TNF 22820162 2646126 In RA-treated THP-1 human monocytic cells , MafB mRNA and protein levels were up-regulated by RA dose and time-dependently , while , additionally , RA and ( TNF ) a , also known to induce monocyte to macrophage differentiation , *increased* [MafB] expression synergistically . Positive_regulation MAFG EPHB2 25219500 2958293 BRAF ( V600E ) increases signaling resulting in phosphorylation and elevated *levels* of [MAFG] , which drives DNA binding . Positive_regulation MAFG MAP2K6 25219500 2958299 BRAF ( V600E ) increases signaling resulting in phosphorylation and elevated *levels* of [MAFG] , which drives DNA binding . Positive_regulation MAG CAPN8 12558973 1051974 Degraded [myelin associated glycoprotein] ( dMAG ) formation from pure human brain myelin associated glycoprotein (MAG) is not *mediated* by or cathepsin L-like activities . Positive_regulation MAG PLAT 24129569 2875075 LRP1 assembles unique co-receptor systems to initiate cell signaling in *response* to and [myelin associated glycoprotein] . Positive_regulation MAG TNF 2342464 134777 We show here that the level of [NF-GMa] binding is *induced* in embryonic fibroblasts by treatment and that the CK-1 sequence from the G-CSF gene is a TNF-alpha-responsive enhancer in these cells . Positive_regulation MAG TNF 2342464 134780 These results demonstrate that [NF-GMa] is a novel transcription factor *inducible* by and binds to a common element in HGF gene promoters . Positive_regulation MAGEA4 TCN1 23124083 2696273 Both [MAGE-A4-H/K-HELP] and Survivin-H/K-HELP cancer vaccine *induced* cancer-specific Th1 and immune responses and cancer-specific C-fixing antibodies ( IgG1 and IgG3 ) in cancer patients . Positive_regulation MAGI1 TNF 12061424 952854 In agreement , MT-III and [BaP1] did not *induce* the synthesis of by resident peritoneal macrophages in vitro . Positive_regulation MAGI2 TNF 15310755 1303537 binding *induces* release of [AIP1] from TNFR1 , resulting in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD , RIP1 , TRAF2 , and AIPl . Positive_regulation MALT1 ID1 20697353 2335477 *enhances* RING1b E3 [ubiquitin ligase] activity through the Mel-18/Bmi-1 polycomb group complex . Positive_regulation MAMLD1 FN1 11358957 834497 Exogenous also *stimulated* TSP1 dependent binding of [F18] to melanoma cells . Positive_regulation MAMLD1 NR5A1 18987498 1983761 and ( 5 ) [CXorf6] can be *regulated* by . Positive_regulation MAMLD1 SF1 23044878 2684713 and ( 4 ) [MAMLD1] is *regulated* by . Positive_regulation MAMLD1 THBS1 11358957 834489 This conformation was not *induced* by known cell surface receptors , whereas binding of [F18] was stimulated when TSP1 bound to fibronectin but not to heparin or fibrinogen . Positive_regulation MAMLD1 THBS1 11358957 834496 Exogenous fibronectin also stimulated *dependent* binding of [F18] to melanoma cells . Positive_regulation MANF TNF 17158207 1694182 Western blot analysis of L6 cell lysates demonstrated impaired insulin stimulated phosphorylation of Akt , [serine/arginine-rich protein] 40 , and glycogen synthase kinase 3beta in *response* to and the short chain C6 ceramide analog . Positive_regulation MAOA BCL10 23926250 2826565 Rines E3 *regulates* [MAO-A] levels and emotional responses . Positive_regulation MAOA CA2 14735783 1181946 This is the first evidence that ammonia and *regulate* [MAO A] in non-synaptic mitochondria in the forebrain and can contribute to oxidative stress in the neurons via MAO A activation . Positive_regulation MAOA CASP3 17883400 1830015 Increased levels of MAO-A activity were induced by STS , accompanied by increased [MAO-A] protein and *activation* of the initiator of the intrinsic pathway , caspase 9 , and the executioner . Positive_regulation MAOA CASP9 17883400 1830016 Increased levels of MAO-A activity were induced by STS , accompanied by increased [MAO-A] protein and *activation* of the initiator of the intrinsic pathway , , and the executioner caspase 3 . Positive_regulation MAOA COMT 1421124 202099 A new inhibitor , nitecapone ( OR-462 ) or clorgyline , a [MAO-A] *inhibitor* , was infused into the 3rd brain ventricle ( i.c.v. ) of conscious male rats . Positive_regulation MAOA DDC 7874502 287552 Enzyme assays demonstrated that activity was unchanged in the gliotic striatum , but both [MAO-A] and MAO-B activities *increased* by 23 % and 21 % , respectively . Positive_regulation MAOA FOXO1 21775495 2484514 Overexpression of dramatically *repressed* both the basal and VPA induced [MAO A] catalytic and promoter activities to 30 to 60 % . Positive_regulation MAOA GRAP2 19650872 2138480 Over-expression of a constitutively active ( MAPK ) *results* in the phosphorylation of the MAO-A protein and inhibition of [MAO-A] activity . Positive_regulation MAOA IL4 15470022 1317854 [MAO-A] was also *induced* in lung carcinoma A549 cells by in parallel with 15-LOX1 . Positive_regulation MAOA IL4 15470022 1317856 In promyelomonocytic U937 cells , which neither express 15-LOX1 nor [MAO-A] in *response* to stimulation , expression of MAO-A was up-regulated following transfection with 15-LOX1 . Positive_regulation MAOA IL4 16049371 1447794 Our findings also suggest that *induced* upregulation of [MAO-A] expression in human peripheral monocytes may proceed via 15-LOX1 dependent and 15-LOX1 independent pathways . Positive_regulation MAOA MALT1 23926250 2826564 Rines E3 *regulates* [MAO-A] levels and emotional responses . Positive_regulation MAOA MAOB 12007928 940683 The present study examined the contribution of the beta-carbolines norharman , an inhibitor of , and harman , an *inhibitor* of [monoamineoxidase A] , which are present in high concentrations in tobacco smoke to the protective action . Positive_regulation MAOA MAOB 22850464 2757208 The enzymatic degradation of brain 5-HT is mainly *mediated* by [monoamine oxidase (MAO)A] and , in the absence of this enzyme , by its cognate isoenzyme . Positive_regulation MAOA MAOB 2501477 113950 After pretreatment with either clorgyline , a [monoamine oxidase (MAO)-A-selective] *inhibitor* , or pargyline , an inhibitor with less selectivity than l-deprenyl , i.c.v . Positive_regulation MAOA MAOB 2788714 118187 Specific activities of both [MAO-A] and MAO-B *increased* during in vitro development of the cultures , with activity increasing 20-fold between the first and fourth week . Positive_regulation MAOA MAOB 3734795 62692 The inhibition of the A and B forms of monoamine oxidase ( MAO ) inside and outside serotonergic , noradrenergic , and dopaminergic synaptosomes in homogenates of rat hypothalamus or striatum by clorgyline , a selective and irreversible [MAO-A] *inhibitor* , and selegiline , a selective and irreversible inhibitor , was examined . Positive_regulation MAOA MAOB 6428496 39252 The LD50 of pethidine was determined in mice pretreated ( 4 h ) either with the nonselective monoamine oxidase ( MAO ) inhibitor , phenelzine or with clorgyline , a selective *inhibitor* of [MAO A] or deprenyl , a selective inhibitor of . Positive_regulation MAOA MAOB 6435178 42367 Measurement of radioactivity showed that the amount of the metabolite produced in the brain from C-14-MPEA was proportional to the MAO activity remaining after combined treatment with a specific [MAO-A] *inhibitor* , clorgyline and a inhibitor , 1-deprenyl , but not by treatment with either inhibitor alone . Positive_regulation MAOA MAOB 7803985 284661 Since [MAO-A] is an isoform of MAO that preferentially uses norepinephrine and serotonin as substrates and *acts* on phenylethylamine and benzylamine as substrates , our findings suggest that the restoration of sexual behavior after the treatment with estradiol benzoate followed by progesterone may be associated with the differential effect exerted by the hormones on MAO subtypes , rather than to the simple decrease in hypothalamic monoamine concentrations as reported in the literature . Positive_regulation MAOA MAOB 8631685 361298 The homology search and disruption of maoA on the chromosome led to the conclusion that is a transcriptional *activator* of [maoA] but not an amine oxidase . Positive_regulation MAOA NOS2 15490317 1321353 In the course of a screening of plant extracts for potential CNS and anti-inflammatory activities , a dichloromethane extract of Salvia miltiorrhiza showed a pronounced inhibitory effect on recombinant [monoamine oxidase A (MAO A)] and on *induction* in Raw 267.4 cells . Positive_regulation MAOA NR3C1 15946989 1434307 Both the and the Sp1 transcription factor were *required* for dexamethasone induced [MAO-A] mRNA expression , as blockade of the GR with RU 486 or ablation of Sp1 binding with mithramycin abrogated MAO-A mRNA induction . Positive_regulation MAOA NR4A1 10606764 655688 Using a rib5 disrupted strain of Saccharomyces cerevisiae which is auxotrophic for riboflavin , [MAO A] and MAO B were expressed separately under control of a galactose inducible GAL10/CYC1 promoter in the *presence* of as the only available riboflavin analogue . Positive_regulation MAOA SLC22A3 24865426 2945511 Knockdown and overexpression of MAOA in human PCa cell lines indicated that [MAOA] *induces* through activation of VEGF and its coreceptor neuropilin-1 . Positive_regulation MAOA SP1 15946989 1434306 Both the glucocorticoid receptor (GR) and the were *required* for dexamethasone induced [MAO-A] mRNA expression , as blockade of the GR with RU 486 or ablation of Sp1 binding with mithramycin abrogated MAO-A mRNA induction . Positive_regulation MAOA SP1 19661285 2150557 Coimmunoprecipitation and ChIP assays showed that SRY and form a transcriptional complex and synergistically *activate* [MAO A] transcription . Positive_regulation MAOA SRY 19661285 2150555 We demonstrated that *activates* both [MAO A-promoter] and catalytic activities in a human male neuroblastoma BE ( 2 ) C cell line . Positive_regulation MAOA SRY 19661285 2150558 Coimmunoprecipitation and ChIP assays showed that and Sp1 form a transcriptional complex and synergistically *activate* [MAO A] transcription . Positive_regulation MAOA STS 17883400 1830014 Increased levels of [MAO-A] activity were *induced* by , accompanied by increased MAO-A protein and activation of the initiator of the intrinsic pathway , caspase 9 , and the executioner caspase 3 . Positive_regulation MAOA TAB2 23926250 2826563 Rines E3 *regulates* [MAO-A] levels and emotional responses . Positive_regulation MAOA TRAF6 23926250 2826561 Rines E3 *regulates* [MAO-A] levels and emotional responses . Positive_regulation MAOA UBE2V1 23926250 2826562 Rines E3 *regulates* [MAO-A] levels and emotional responses . Positive_regulation MAOB EPHB2 10777699 686942 These results show that [MAO-B] *induces* activation and cell mitogenesis through H ( 2 ) O ( 2 ) production . Positive_regulation MAOB MAOA 12007928 940684 The present study examined the contribution of the beta-carbolines norharman , an *inhibitor* of [monoamineoxidase B] , and harman , an inhibitor of , which are present in high concentrations in tobacco smoke to the protective action . Positive_regulation MAOB MAOA 22850464 2757209 The enzymatic degradation of brain 5-HT is mainly *mediated* by and , in the absence of this enzyme , by its cognate isoenzyme [MAOB] . Positive_regulation MAOB MAOA 22982254 2716121 Striatal tissue activity was unchanged by 6-OHDA lesion but [MAO-B] activity was *increased* by 16 % , together with a 45 % increase in glial cell content . Positive_regulation MAOB MAOA 2501477 113951 After pretreatment with either clorgyline , a inhibitor , or pargyline , an [MAO-B-selective] *inhibitor* with less selectivity than l-deprenyl , i.c.v . Positive_regulation MAOB MAOA 3734795 62693 The inhibition of the A and B forms of monoamine oxidase ( MAO ) inside and outside serotonergic , noradrenergic , and dopaminergic synaptosomes in homogenates of rat hypothalamus or striatum by clorgyline , a selective and irreversible inhibitor , and selegiline , a selective and irreversible [MAO-B] *inhibitor* , was examined . Positive_regulation MAOB MAOA 6428496 39253 The LD50 of pethidine was determined in mice pretreated ( 4 h ) either with the nonselective monoamine oxidase ( MAO ) inhibitor , phenelzine or with clorgyline , a selective inhibitor of or deprenyl , a selective *inhibitor* of [MAO B] . Positive_regulation MAOB MAOA 6435178 42368 Measurement of radioactivity showed that the amount of the metabolite produced in the brain from C-14-MPEA was proportional to the MAO activity remaining after combined treatment with a specific inhibitor , clorgyline and a [MAO-B] *inhibitor* , 1-deprenyl , but not by treatment with either inhibitor alone . Positive_regulation MAOB MAOA 7803985 284662 Since is an isoform of MAO that preferentially uses norepinephrine and serotonin as substrates and [MAO-B] *acts* on phenylethylamine and benzylamine as substrates , our findings suggest that the restoration of sexual behavior after the treatment with estradiol benzoate followed by progesterone may be associated with the differential effect exerted by the hormones on MAO subtypes , rather than to the simple decrease in hypothalamic monoamine concentrations as reported in the literature . Positive_regulation MAP1LC3A EPHB2 24952354 2952353 Pretreatment with NAC ( N-acetyl-l-cysteine ) , a well-known antioxidant , completely blocked the SFN induced increase in [LC3-II] levels and *activation* of . Positive_regulation MAP1LC3A EPHB2 25128814 2957252 can *regulate* cellular levels of [LC3B] and SQSTM1/p62 at expression levels . Positive_regulation MAP1LC3A MAP2K6 25128814 2957258 can *regulate* cellular levels of [LC3B] and SQSTM1/p62 at expression levels . Positive_regulation MAP1LC3A TLR7 23831471 2824921 This suppressive effect of Atg5 may not be associated with autophagic processes because MyD88 itself was not degraded and because stimulation did not *induce* [LC3] punctate formation and LC3 conversion . Positive_regulation MAP1LC3A TNF 11440974 833347 *increased* expression of [light chain 3 (LC-3)] , a protein shown previously to facilitate fibronectin mRNA translation through its interaction with an adenosine-uracil rich element ( ARE ) in the 3'-untranslated region of fibronectin mRNA . Positive_regulation MAP1LC3A TNF 19050324 1999439 Meanwhile , treatment *induced* a significant increase in the expression of [LC3-II] without a significant change in the expression of beclin-1 . Positive_regulation MAP2 CAPN8 16904106 1639017 In addition , it appears that rather than underlying the initial disruption of microtubule structure via MAP2 proteolysis , activity instead may *contribute* to the degradation of irregularly aggregated [MAP2] observed following microtubule depolymerization . Positive_regulation MAP2 CAPN8 18157632 1869241 Both and caspase-3 inhibitors *increased* the levels of [MAP-2] and spectrin in penumbra and core significantly after focal cerebral ischemia-reperfusion . Positive_regulation MAP2 CAPN8 2013758 156721 Among other things , these results suggest a role for the *induced* degradation of [MAP-2] , as well as spectrin , in such physiological processes as alterations in synaptic efficacy , dendritic remodeling , and in pathological processes associated with neurodegeneration . Positive_regulation MAP2 CAPN8 8391085 224184 The effects of cAMP dependent protein kinase ( cAMP-PK ) and Ca2+/calmodulin dependent protein kinase II ( CaMKII ) phosphorylation on the *mediated* degradation of [microtubule associated protein 2 (MAP-2)] were studied . Positive_regulation MAP2 S100B 9751173 533514 also *induced* increased neuronal expression of the microtubule associated protein [MAP2] , an effect that is consistent with trophic effects of S100beta on neurite outgrowth . Positive_regulation MAP2K1 ANGPT1 12890486 1117282 Localization of Tie2 and phospholipase D in endothelial caveolae is involved in *induced* [MEK/ERK] phosphorylation and migration in endothelial cells . Positive_regulation MAP2K1 ANGPT1 12890486 1117406 Ang1 induced MEK/ERK activation was abrogated when PLD was inhibited , suggesting that PLD mediates *induced* [MEK/ERK] activation . Positive_regulation MAP2K1 CCND1 22579115 2609553 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated and Cyclin B1 proteins as well as *activation* of PI3K/Akt and [Raf/MEK/ERK] , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation MAP2K1 CD14 16879219 1593838 Lipopolysaccharide induced decreased protein S expression in liver cells is mediated by [MEK/ERK] signaling and NFkappaB *activation* : involvement of membrane bound and toll-like receptor-4 . Positive_regulation MAP2K1 CD14 16879219 1593857 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by [MEK/ERK] signaling and NFkappaB activation and that membrane bound and TLR-4 are *involved* in this mechanism . Positive_regulation MAP2K1 CLU 15857407 1400244 The [mitogen activated protein kinase kinase] and protein kinase C inhibitors PD98059 and H7 inhibited mediated *induction* of reactive nitrogen intermediate secretion from cultured microglia . Positive_regulation MAP2K1 CLU 19218870 2039532 Exogenous *stimulates* Ras dependent [Raf-1/mitogen activated protein kinase kinase] ( MEK ) /ERK activation . Positive_regulation MAP2K1 CTGF 15855807 1425618 TGF-beta1 induced connective tissue growth factor ( ) expression in human renal proximal tubule epithelial cells *requires* [Ras/MEK/ERK] and Smad signalling . Positive_regulation MAP2K1 EPHB2 10207078 606736 Nevertheless , *activation* of by transient transfection of constitutively active mutant [MAP kinase kinase 1 (MKK1)] enhanced endogenous topoisomerase II activity by fourfold . Positive_regulation MAP2K1 EPHB2 10980611 731551 MEK inhibitor U0126 blocked the induction , while activated [MEK-1] transfected into a rat mammary adenocarcinoma cell line *induced* a sustained activation of and up-regulated SMC/Muc4 expression . Positive_regulation MAP2K1 EPHB2 10996792 733913 As in proliferating cells , activation during G0 *required* the MAPkinase kinase [MEK] and was partially dependent on cell adhesion . Positive_regulation MAP2K1 EPHB2 11304535 819980 However , cyclin E expression is ineffectual in rescuing these effects when ERK activation is blocked by treatment with PD98059 , a selective inhibitor of [MEK] *activation* of . Positive_regulation MAP2K1 EPHB2 12675684 1076704 In contrast , the *activation* of by constitutively active forms of [MAP kinase kinase (MEK)] was not inhibited , suggesting that the actions of SptP were mediated by Raf-1 . Positive_regulation MAP2K1 EPHB2 15304546 1322387 Furthermore , *activation* of by the coexpression of constitutively active [MAPKK/MEK] predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAP2K1 EPHB2 15843535 1398470 As in the classical pathway , BCR induced activation in the new , PI3K independent pathway *required* [MEK] and was reflected in c-Raf . Positive_regulation MAP2K1 EPHB2 15855657 1439592 Activation of ERK was attenuated by drugs that disassemble the actin cytoskeleton ( cytochalasin D , latrunculin B ) , and these compounds interfered with the *activation* of by [mitogen activated protein kinase kinase] ( MEK ) . Positive_regulation MAP2K1 EPHB2 16210650 1464507 phosphorylation and chemokine production in response to LPA *require* IL-4 dependent up-regulation of [MEK-1] expression by a pathway involving PI3K . Positive_regulation MAP2K1 EPHB2 17337598 1765824 A pharmacological inhibitor of MEK activity inhibits LPA stimulated WT Hic-5 cell migration and ERK phosphorylation , suggesting Hic-5 enhances migration via [MEK] *activation* of . Positive_regulation MAP2K1 EPHB2 17879163 1818403 Treatment with V+H- decreased the phosphorylation of extracellular signal regulated kinase ( ERK ) 1 and 2 , and direct *activation* of by constitutively active [MEK1] , an ERK kinase , increased ERK1 and ERK2 phosphorylation and inhibited the increase in apoptosis induced by V+H- . Positive_regulation MAP2K1 EPHB2 18194435 1895319 Although [mitogen activated protein kinase kinase] ( MEK ) and extracellular signal regulated protein kinase ( ERK ) are activated by GW5074 , pharmacological inhibition of signaling by U0126 or PD98059 does not *reduce* neuroprotection suggesting that B-Raf signals through a non-canonical signaling pathway . Positive_regulation MAP2K1 EPHB2 18463290 1910051 Using 293A cells and in vitro experiments , we detail the formation of a ternary complex of , *activation* of [MEK1] and ERK1/2 kinase activities by hBVR , and phosphorylation of hBVR by ERK1/2 . Positive_regulation MAP2K1 EPHB2 19219045 2044430 The Mek heterodimer is negatively regulated by *mediated* phosphorylation of [Mek1] on Thr292 , a residue missing in Mek2 . Positive_regulation MAP2K1 EPHB2 19411256 2089713 Additionally , constitutive *activation* of by constitutively activated [MEK1] rescues the KLF5 depletion induced MKP-1 down-regulation . Positive_regulation MAP2K1 EPHB2 21914493 2506757 Inhibition of GSK-3ß by the kinase-inactive GSK-3ß mutant or *activation* of by the active [MEK-1] mutant abrogated glucocorticoid induced inhibition of osteoblast differentiation . Positive_regulation MAP2K1 EPHB2 22085529 2534362 Mitogen activated protein kinase kinase ( [MEK) 1/2] *inhibitor* , UO126 and inhibitor II , FR180204 blocked the Elk-1 phosphorylation and activation . Positive_regulation MAP2K1 EPHB2 22328534 2642858 PD98059 , [MEK] *inhibitor* , or U0126 , inhibitor , reduced SNU668 cell migration accompanying an increase in p-GSK-3a , ß-catenin and E-cadherin . Positive_regulation MAP2K1 EPHB2 22506069 2583976 Activations of [MEK] , ERK , and NF-?B pathways after CCL5 treatment were demonstrated , and CCL5 induced expression of integrin and migration activity was *inhibited* by the specific inhibitor and mutant of MEK , , and NF-?B cascades . Positive_regulation MAP2K1 EPHB2 22740332 2715445 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Positive_regulation MAP2K1 EPHB2 22785235 2691771 TRH induced CRE promoter was inhibited by mitogen activated protein kinase ( MEK ) inhibitor and was *increased* by overexpression of [MEK kinase (MEKK)] . Positive_regulation MAP2K1 EPHB2 22892241 2666335 However , unlike ( V600E ) Braf , pathway activation was mediated by both Craf and Braf , and ATP-competitive RAF inhibitors *induced* paradoxical [Mek/Erk] pathway activation . Positive_regulation MAP2K1 EPHB2 7838428 286297 The protein expression profiles were almost equivalent , but the MEK expression was slightly advanced , suggesting that the observed up-regulation of [MEK] was not *due* to that of . Positive_regulation MAP2K1 EPHB2 8226933 235472 Phosphorylation of [MEK] is also *stimulated* by . Positive_regulation MAP2K1 HBEGF 22873932 2647089 Phosphoimmunoblotting of PCMOs indicated that both EGF and *activated* [MEK-1/2] and ERK1/2 in a concentration dependent fashion with the effect of EGF being more prominent . Positive_regulation MAP2K1 ID1 14742319 1250766 *induced* [Raf/MEK] pathway activation is essential for its protective role against taxol induced apoptosis in nasopharyngeal carcinoma cells . Positive_regulation MAP2K1 IFI27 10951574 723758 Inhibition of [MEK] activation completely abrogated OSM and IL-6 *induced* p27kip1 accumulation , while expression of dominant negative STAT5 decreased the OSM and IL-6 mediated inhibition of DNA-synthesis and partially inhibited accumulation . Positive_regulation MAP2K1 IL1B 10965886 728047 In addition , the MAP kinase-kinase [MEK-1] and the ribosomal S6-kinase RSK-1 are also phosphorylated in *response* to . Positive_regulation MAP2K1 IL1B 11179516 784772 We found that *induced* ERK phosphorylation , PD153035 and [MEK] inhibitor PD98059 blocked IL-1 beta induced ERK activity . Positive_regulation MAP2K1 IL1B 16043966 1459730 Western blot analysis demonstrated that *increased* the activation of phosphorylated [MEK] and p38 MAPK in GH3 cells . Positive_regulation MAP2K1 IL1B 20525168 2284213 We have shown that *induced* miR-146a expression in HASM and that this was regulated at the transcriptional level by NF-kappaB and at the post-transcriptional level by the [MEK-1/2] and JNK-1/2 . Positive_regulation MAP2K1 MAP2K6 11495722 846413 The inhibitor , PD98059 *attenuated* ERK1/2 and [MEK1/2] phosphorylation , as well as the migration shift of Lck induced by H ( 2 ) O ( 2 ) . Positive_regulation MAP2K1 MAP2K6 18463290 1910057 Using 293A cells and in vitro experiments , we detail the formation of a ternary complex of , *activation* of [MEK1] and ERK1/2 kinase activities by hBVR , and phosphorylation of hBVR by ERK1/2 . Positive_regulation MAP2K1 MAP2K6 7962002 279223 Partially purified activator *stimulated* phosphorylation of [MEK1] on residues tentatively identified as serine 218 and serine 222 . Positive_regulation MAP2K1 PLAU 12493778 1056695 Further , we show that growth factor induced expression *requires* MEKK1 dependent [MKK1] and JNK activity and that transfection of MEKK1 into knockout cells restores inducible uPA expression and activity . Positive_regulation MAP2K1 PLAU 15874933 1405691 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( [MEK1/2] ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Positive_regulation MAP2K1 PLAU 17681345 1822236 These latter effects were mediated by *induced* activation of the mitogen activated protein kinase/extracellular signal regulated kinase ( [MEK] ) . Positive_regulation MAP2K1 PLAU 22155455 2542704 uPA downregulated PON1 gene expression via inactivation of peroxisome proliferator activated receptor-? ( PPAR? ) activity , and this effect was dependent on mediated [mitogen activated protein kinase kinase] *activation* . Positive_regulation MAP2K1 PLAU 22155455 2542726 Mechanistic studies showed that *enhanced* [mitogen activated protein kinase kinase-PPAR?] interaction , resulting in PPAR? nuclear export to the cytosol . Positive_regulation MAP2K1 S100B 22082983 2540801 In RAGE-A10 , *activated* JNK , [MEK-1] and p38 . Positive_regulation MAP2K1 STK39 10924861 718559 Genistein , a tyrosine kinase inhibitor , H7 , a inhibitor , and PD 98059 , a [MEK] *inhibitor* , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation MAP2K1 STK39 7623807 315945 The Raf-1 functions downstream from Ras to *activate* [mitogen activated protein kinase kinase] , but the mechanisms of Raf-1 activation are incompletely understood . Positive_regulation MAP2K1 TNF 10075082 594852 Beta-lapachone also abolished *induced* activation of AP-1 , c-Jun N-terminal kinase , and [mitogen activated protein kinase kinase] ( MAPKK or MEK ) . Positive_regulation MAP2K1 TNF 10439045 635249 gamma-GCS also abolished the activation of AP-1 induced by TNF and inhibited *induced* activation of JNK and [mitogen activated protein kinase kinase] . Positive_regulation MAP2K1 TNF 10586080 571811 Silymarin also inhibited the induced *activation* of [mitogen activated protein kinase kinase] and c-Jun N-terminal kinase and abrogated TNF induced cytotoxicity and caspase activation . Positive_regulation MAP2K1 TNF 10788437 688682 hCG abrogated the *induced* activation of [mitogen activated protein kinase kinase] and c-Jun N-terminal kinase required for NF-kappaB and AP-1 , respectively . Positive_regulation MAP2K1 TNF 10843709 700184 Resveratrol also inhibited the induced *activation* of [mitogen activated protein kinase kinase] and c-Jun N-terminal kinase and abrogated TNF induced cytotoxicity and caspase activation . Positive_regulation MAP2K1 TNF 11149911 780451 mediated *activation* of [MEK/ERK] and EGR-1 can be blocked by adenoviral expression of a dominant negative mutant of IKK2 , whereas the VEGF signaling pathway is unaffected . Positive_regulation MAP2K1 TNF 11546645 856533 We found that [MEK-1/2] is *activated* by within minutes and is dependent on TK and p42/44 MAPKs . Positive_regulation MAP2K1 TNF 14566965 1155099 In both prechondrocytes and articular chondrocytes , *induced* concentration dependent activation of [MEK1/2] and NF-kappaB , but not p38 or JNK . Positive_regulation MAP2K1 TNF 16452391 1547911 The Syk inhibitor also decreased *induced* [mitogen activated protein kinase kinase] ( MKK) 4 phosphorylation but not MKK3 and MKK6 phosphorylation , which is consistent with its selective sparing of p38 . Positive_regulation MAP2K1 TNF 19144181 2079121 Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by *induced* [MEK/ERK] signalling . Positive_regulation MAP2K1 TNF 19144181 2079129 *activates* [mitogen activated kinase kinase (MEK)/extracellular] regulated kinase (ERK) in chondrocytes ; Positive_regulation MAP2K1 TNF 19628074 2112817 and/or TGF-alpha stimulation *increased* [phospho-MEK] and phospho-ERK in cells transfected with TNFR1 siRNA . Positive_regulation MAP2K1 TNF 21320357 2393843 The effects of IL-1ß and on EPCR shedding in DU-145 cells are *mediated* by [MEK/ERK] 1/2 , JNK , and p38 MAPK signalling cascades . Positive_regulation MAP2K1 TNF 24151609 2859755 In our study , we found that a treatments *induce* [MEK] and AKT phosphorylation . Positive_regulation MAP2K1 TNF 8900184 393463 *Activation* of [mitogen activated protein kinase kinase] 6 by osmotic shock , , and H2O2 . Positive_regulation MAP2K1 TNF 9582369 504226 In addition , Mn-SOD blocked the *mediated* activation of activated protein-1 , stress activated c-Jun protein kinase , and [mitogen activated protein kinase kinase] . Positive_regulation MAP2K2 ANGPT1 12890486 1117290 Localization of Tie2 and phospholipase D in endothelial caveolae is involved in *induced* [MEK/ERK] phosphorylation and migration in endothelial cells . Positive_regulation MAP2K2 ANGPT1 12890486 1117413 Ang1 induced MEK/ERK activation was abrogated when PLD was inhibited , suggesting that PLD mediates induced [MEK/ERK] *activation* . Positive_regulation MAP2K2 CCND1 22579115 2609554 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated and Cyclin B1 proteins as well as *activation* of PI3K/Akt and [Raf/MEK/ERK] , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation MAP2K2 CD14 16879219 1593839 Lipopolysaccharide induced decreased protein S expression in liver cells is mediated by [MEK/ERK] signaling and NFkappaB *activation* : involvement of membrane bound and toll-like receptor-4 . Positive_regulation MAP2K2 CD14 16879219 1593859 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by [MEK/ERK] signaling and NFkappaB activation and that membrane bound and TLR-4 are *involved* in this mechanism . Positive_regulation MAP2K2 CLU 15857407 1400245 The [mitogen activated protein kinase kinase] and protein kinase C inhibitors PD98059 and H7 inhibited mediated *induction* of reactive nitrogen intermediate secretion from cultured microglia . Positive_regulation MAP2K2 CLU 19218870 2039536 Exogenous *stimulates* Ras dependent [Raf-1/mitogen activated protein kinase kinase] ( MEK ) /ERK activation . Positive_regulation MAP2K2 CTGF 15855807 1425619 TGF-beta1 induced connective tissue growth factor ( ) expression in human renal proximal tubule epithelial cells *requires* [Ras/MEK/ERK] and Smad signalling . Positive_regulation MAP2K2 EPHB2 10996792 733914 As in proliferating cells , activation during G0 *required* the MAPkinase kinase [MEK] and was partially dependent on cell adhesion . Positive_regulation MAP2K2 EPHB2 11304535 819981 However , cyclin E expression is ineffectual in rescuing these effects when ERK activation is blocked by treatment with PD98059 , a selective inhibitor of [MEK] *activation* of . Positive_regulation MAP2K2 EPHB2 12675684 1076705 In contrast , the *activation* of by constitutively active forms of [MAP kinase kinase (MEK)] was not inhibited , suggesting that the actions of SptP were mediated by Raf-1 . Positive_regulation MAP2K2 EPHB2 15304546 1322401 Furthermore , *activation* of by the coexpression of constitutively active [MAPKK/MEK] predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAP2K2 EPHB2 15843535 1398472 As in the classical pathway , BCR induced activation in the new , PI3K independent pathway *required* [MEK] and was reflected in c-Raf . Positive_regulation MAP2K2 EPHB2 15855657 1439593 Activation of ERK was attenuated by drugs that disassemble the actin cytoskeleton ( cytochalasin D , latrunculin B ) , and these compounds interfered with the *activation* of by [mitogen activated protein kinase kinase] ( MEK ) . Positive_regulation MAP2K2 EPHB2 17337598 1765825 A pharmacological inhibitor of MEK activity inhibits LPA stimulated WT Hic-5 cell migration and ERK phosphorylation , suggesting Hic-5 enhances migration via [MEK] *activation* of . Positive_regulation MAP2K2 EPHB2 18194435 1895320 Although [mitogen activated protein kinase kinase] ( MEK ) and extracellular signal regulated protein kinase ( ERK ) are activated by GW5074 , pharmacological inhibition of signaling by U0126 or PD98059 does not *reduce* neuroprotection suggesting that B-Raf signals through a non-canonical signaling pathway . Positive_regulation MAP2K2 EPHB2 22085529 2534363 Mitogen activated protein kinase kinase ( [MEK) 1/2] *inhibitor* , UO126 and inhibitor II , FR180204 blocked the Elk-1 phosphorylation and activation . Positive_regulation MAP2K2 EPHB2 22328534 2642859 PD98059 , [MEK] *inhibitor* , or U0126 , inhibitor , reduced SNU668 cell migration accompanying an increase in p-GSK-3a , ß-catenin and E-cadherin . Positive_regulation MAP2K2 EPHB2 22506069 2583977 Activations of [MEK] , ERK , and NF-?B pathways after CCL5 treatment were demonstrated , and CCL5 induced expression of integrin and migration activity was *inhibited* by the specific inhibitor and mutant of MEK , , and NF-?B cascades . Positive_regulation MAP2K2 EPHB2 22740332 2715446 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Positive_regulation MAP2K2 EPHB2 22785235 2691785 TRH induced CRE promoter was inhibited by mitogen activated protein kinase ( MEK ) inhibitor and was *increased* by overexpression of [MEK kinase (MEKK)] . Positive_regulation MAP2K2 EPHB2 22892241 2666337 However , unlike ( V600E ) Braf , pathway activation was mediated by both Craf and Braf , and ATP-competitive RAF inhibitors *induced* paradoxical [Mek/Erk] pathway activation . Positive_regulation MAP2K2 EPHB2 7838428 286298 The protein expression profiles were almost equivalent , but the MEK expression was slightly advanced , suggesting that the observed up-regulation of [MEK] was not *due* to that of . Positive_regulation MAP2K2 EPHB2 8226933 235473 Phosphorylation of [MEK] is also *stimulated* by . Positive_regulation MAP2K2 HBEGF 22873932 2647091 Phosphoimmunoblotting of PCMOs indicated that both EGF and *activated* [MEK-1/2] and ERK1/2 in a concentration dependent fashion with the effect of EGF being more prominent . Positive_regulation MAP2K2 ID1 14742319 1250767 *induced* [Raf/MEK] pathway activation is essential for its protective role against taxol induced apoptosis in nasopharyngeal carcinoma cells . Positive_regulation MAP2K2 IFI27 10951574 723761 Inhibition of [MEK] activation completely abrogated OSM and IL-6 *induced* p27kip1 accumulation , while expression of dominant negative STAT5 decreased the OSM and IL-6 mediated inhibition of DNA-synthesis and partially inhibited accumulation . Positive_regulation MAP2K2 IL1B 11179516 784773 We found that *induced* ERK phosphorylation , PD153035 and [MEK] inhibitor PD98059 blocked IL-1 beta induced ERK activity . Positive_regulation MAP2K2 IL1B 16043966 1459731 Western blot analysis demonstrated that *increased* the activation of phosphorylated [MEK] and p38 MAPK in GH3 cells . Positive_regulation MAP2K2 IL1B 20525168 2284214 We have shown that *induced* miR-146a expression in HASM and that this was regulated at the transcriptional level by NF-kappaB and at the post-transcriptional level by the [MEK-1/2] and JNK-1/2 . Positive_regulation MAP2K2 PLAU 17681345 1822237 These latter effects were mediated by induced *activation* of the mitogen activated protein kinase/extracellular signal regulated kinase ( [MEK] ) . Positive_regulation MAP2K2 PLAU 22155455 2542705 uPA downregulated PON1 gene expression via inactivation of peroxisome proliferator activated receptor-? ( PPAR? ) activity , and this effect was dependent on mediated [mitogen activated protein kinase kinase] *activation* . Positive_regulation MAP2K2 PLAU 22155455 2542727 Mechanistic studies showed that *enhanced* [mitogen activated protein kinase kinase-PPAR?] interaction , resulting in PPAR? nuclear export to the cytosol . Positive_regulation MAP2K2 STK39 10924861 718574 Genistein , a tyrosine kinase inhibitor , H7 , a inhibitor , and PD 98059 , a [MEK] *inhibitor* , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation MAP2K2 STK39 7623807 315961 The Raf-1 functions downstream from Ras to *activate* [mitogen activated protein kinase kinase] , but the mechanisms of Raf-1 activation are incompletely understood . Positive_regulation MAP2K2 TNF 10075082 594853 Beta-lapachone also abolished *induced* activation of AP-1 , c-Jun N-terminal kinase , and [mitogen activated protein kinase kinase] ( MAPKK or MEK ) . Positive_regulation MAP2K2 TNF 10439045 635250 gamma-GCS also abolished the activation of AP-1 induced by TNF and inhibited induced *activation* of JNK and [mitogen activated protein kinase kinase] . Positive_regulation MAP2K2 TNF 10586080 571812 Silymarin also inhibited the *induced* activation of [mitogen activated protein kinase kinase] and c-Jun N-terminal kinase and abrogated TNF induced cytotoxicity and caspase activation . Positive_regulation MAP2K2 TNF 10788437 688683 hCG abrogated the induced *activation* of [mitogen activated protein kinase kinase] and c-Jun N-terminal kinase required for NF-kappaB and AP-1 , respectively . Positive_regulation MAP2K2 TNF 10843709 700185 Resveratrol also inhibited the *induced* activation of [mitogen activated protein kinase kinase] and c-Jun N-terminal kinase and abrogated TNF induced cytotoxicity and caspase activation . Positive_regulation MAP2K2 TNF 11149911 780453 mediated *activation* of [MEK/ERK] and EGR-1 can be blocked by adenoviral expression of a dominant negative mutant of IKK2 , whereas the VEGF signaling pathway is unaffected . Positive_regulation MAP2K2 TNF 11546645 856534 We found that [MEK-1/2] is *activated* by within minutes and is dependent on TK and p42/44 MAPKs . Positive_regulation MAP2K2 TNF 16452391 1547912 The Syk inhibitor also decreased *induced* [mitogen activated protein kinase kinase] ( MKK) 4 phosphorylation but not MKK3 and MKK6 phosphorylation , which is consistent with its selective sparing of p38 . Positive_regulation MAP2K2 TNF 19144181 2079122 Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by *induced* [MEK/ERK] signalling . Positive_regulation MAP2K2 TNF 19144181 2079130 *activates* [mitogen activated kinase kinase (MEK)/extracellular] regulated kinase (ERK) in chondrocytes ; Positive_regulation MAP2K2 TNF 19628074 2112818 and/or TGF-alpha stimulation *increased* [phospho-MEK] and phospho-ERK in cells transfected with TNFR1 siRNA . Positive_regulation MAP2K2 TNF 21320357 2393845 The effects of IL-1ß and on EPCR shedding in DU-145 cells are *mediated* by [MEK/ERK] 1/2 , JNK , and p38 MAPK signalling cascades . Positive_regulation MAP2K2 TNF 24151609 2859756 In our study , we found that a treatments *induce* [MEK] and AKT phosphorylation . Positive_regulation MAP2K2 TNF 8900184 393464 *Activation* of [mitogen activated protein kinase kinase] 6 by osmotic shock , , and H2O2 . Positive_regulation MAP2K2 TNF 9582369 504227 In addition , Mn-SOD blocked the mediated *activation* of activated protein-1 , stress activated c-Jun protein kinase , and [mitogen activated protein kinase kinase] . Positive_regulation MAP2K3 ANGPT1 12890486 1117298 Localization of Tie2 and phospholipase D in endothelial caveolae is involved in *induced* [MEK/ERK] phosphorylation and migration in endothelial cells . Positive_regulation MAP2K3 ANGPT1 12890486 1117420 Ang1 induced MEK/ERK activation was abrogated when PLD was inhibited , suggesting that PLD mediates *induced* [MEK/ERK] activation . Positive_regulation MAP2K3 CCND1 22579115 2609555 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated and Cyclin B1 proteins as well as *activation* of PI3K/Akt and [Raf/MEK/ERK] , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation MAP2K3 CD14 16879219 1593840 Lipopolysaccharide induced decreased protein S expression in liver cells is mediated by [MEK/ERK] signaling and NFkappaB *activation* : involvement of membrane bound and toll-like receptor-4 . Positive_regulation MAP2K3 CD14 16879219 1593861 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by [MEK/ERK] signaling and NFkappaB activation and that membrane bound and TLR-4 are *involved* in this mechanism . Positive_regulation MAP2K3 CLU 15857407 1400246 The [mitogen activated protein kinase kinase] and protein kinase C inhibitors PD98059 and H7 inhibited mediated *induction* of reactive nitrogen intermediate secretion from cultured microglia . Positive_regulation MAP2K3 CLU 19218870 2039540 Exogenous *stimulates* Ras dependent [Raf-1/mitogen activated protein kinase kinase] ( MEK ) /ERK activation . Positive_regulation MAP2K3 CTGF 15855807 1425620 TGF-beta1 induced connective tissue growth factor ( ) expression in human renal proximal tubule epithelial cells *requires* [Ras/MEK/ERK] and Smad signalling . Positive_regulation MAP2K3 EPHB2 10996792 733915 As in proliferating cells , activation during G0 *required* the MAPkinase kinase [MEK] and was partially dependent on cell adhesion . Positive_regulation MAP2K3 EPHB2 11304535 819982 However , cyclin E expression is ineffectual in rescuing these effects when ERK activation is blocked by treatment with PD98059 , a selective inhibitor of [MEK] *activation* of . Positive_regulation MAP2K3 EPHB2 12675684 1076706 In contrast , the *activation* of by constitutively active forms of [MAP kinase kinase (MEK)] was not inhibited , suggesting that the actions of SptP were mediated by Raf-1 . Positive_regulation MAP2K3 EPHB2 15304546 1322415 Furthermore , *activation* of by the coexpression of constitutively active [MAPKK/MEK] predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAP2K3 EPHB2 15843535 1398474 As in the classical pathway , BCR induced activation in the new , PI3K independent pathway *required* [MEK] and was reflected in c-Raf . Positive_regulation MAP2K3 EPHB2 15855657 1439594 Activation of ERK was attenuated by drugs that disassemble the actin cytoskeleton ( cytochalasin D , latrunculin B ) , and these compounds interfered with the *activation* of by [mitogen activated protein kinase kinase] ( MEK ) . Positive_regulation MAP2K3 EPHB2 17337598 1765826 A pharmacological inhibitor of MEK activity inhibits LPA stimulated WT Hic-5 cell migration and ERK phosphorylation , suggesting Hic-5 enhances migration via [MEK] *activation* of . Positive_regulation MAP2K3 EPHB2 18194435 1895321 Although [mitogen activated protein kinase kinase] ( MEK ) and extracellular signal regulated protein kinase ( ERK ) are activated by GW5074 , pharmacological inhibition of signaling by U0126 or PD98059 does not *reduce* neuroprotection suggesting that B-Raf signals through a non-canonical signaling pathway . Positive_regulation MAP2K3 EPHB2 22328534 2642860 PD98059 , [MEK] *inhibitor* , or U0126 , inhibitor , reduced SNU668 cell migration accompanying an increase in p-GSK-3a , ß-catenin and E-cadherin . Positive_regulation MAP2K3 EPHB2 22506069 2583978 Activations of [MEK] , ERK , and NF-?B pathways after CCL5 treatment were demonstrated , and CCL5 induced expression of integrin and migration activity was *inhibited* by the specific inhibitor and mutant of MEK , , and NF-?B cascades . Positive_regulation MAP2K3 EPHB2 22740332 2715447 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Positive_regulation MAP2K3 EPHB2 22785235 2691799 TRH induced CRE promoter was inhibited by mitogen activated protein kinase ( MEK ) inhibitor and was *increased* by overexpression of [MEK kinase (MEKK)] . Positive_regulation MAP2K3 EPHB2 22892241 2666339 However , unlike ( V600E ) Braf , pathway activation was mediated by both Craf and Braf , and ATP-competitive RAF inhibitors *induced* paradoxical [Mek/Erk] pathway activation . Positive_regulation MAP2K3 EPHB2 7838428 286299 The protein expression profiles were almost equivalent , but the MEK expression was slightly advanced , suggesting that the observed up-regulation of [MEK] was not *due* to that of . Positive_regulation MAP2K3 EPHB2 8226933 235474 Phosphorylation of [MEK] is also *stimulated* by . Positive_regulation MAP2K3 ID1 14742319 1250768 induced [Raf/MEK] pathway *activation* is essential for its protective role against taxol induced apoptosis in nasopharyngeal carcinoma cells . Positive_regulation MAP2K3 IFI27 10951574 723764 Inhibition of [MEK] activation completely abrogated OSM and IL-6 *induced* p27kip1 accumulation , while expression of dominant negative STAT5 decreased the OSM and IL-6 mediated inhibition of DNA-synthesis and partially inhibited accumulation . Positive_regulation MAP2K3 IL1B 10593906 572873 In previous studies we demonstrated that can *activate* MKK4/SEK1 , [MKK3] , and MKK6 in renal mesangial cells ; Positive_regulation MAP2K3 IL1B 11179516 784774 We found that *induced* ERK phosphorylation , PD153035 and [MEK] inhibitor PD98059 blocked IL-1 beta induced ERK activity . Positive_regulation MAP2K3 IL1B 16043966 1459732 Western blot analysis demonstrated that *increased* the activation of phosphorylated [MEK] and p38 MAPK in GH3 cells . Positive_regulation MAP2K3 IL1B 9786861 540951 Furthermore , our experiments confirm that *activates* MAP kinase kinase-4 (MKK4)/SEK1 , [MKK3] , and MKK6 in renal mesangial cells . Positive_regulation MAP2K3 PLAU 15874933 1405692 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , [MAP kinase kinase (MKK)3/6] , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Positive_regulation MAP2K3 PLAU 17681345 1822238 These latter effects were mediated by *induced* activation of the mitogen activated protein kinase/extracellular signal regulated kinase ( [MEK] ) . Positive_regulation MAP2K3 PLAU 22155455 2542706 uPA downregulated PON1 gene expression via inactivation of peroxisome proliferator activated receptor-? ( PPAR? ) activity , and this effect was dependent on mediated [mitogen activated protein kinase kinase] *activation* . Positive_regulation MAP2K3 PLAU 22155455 2542728 Mechanistic studies showed that *enhanced* [mitogen activated protein kinase kinase-PPAR?] interaction , resulting in PPAR? nuclear export to the cytosol . Positive_regulation MAP2K3 STK39 10924861 718589 Genistein , a tyrosine kinase inhibitor , H7 , a inhibitor , and PD 98059 , a [MEK] *inhibitor* , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation MAP2K3 STK39 7623807 315977 The Raf-1 functions downstream from Ras to *activate* [mitogen activated protein kinase kinase] , but the mechanisms of Raf-1 activation are incompletely understood . Positive_regulation MAP2K3 TNF 10075082 594854 Beta-lapachone also abolished induced *activation* of AP-1 , c-Jun N-terminal kinase , and [mitogen activated protein kinase kinase] ( MAPKK or MEK ) . Positive_regulation MAP2K3 TNF 10439045 635251 gamma-GCS also abolished the activation of AP-1 induced by TNF and inhibited *induced* activation of JNK and [mitogen activated protein kinase kinase] . Positive_regulation MAP2K3 TNF 10586080 571813 Silymarin also inhibited the induced *activation* of [mitogen activated protein kinase kinase] and c-Jun N-terminal kinase and abrogated TNF induced cytotoxicity and caspase activation . Positive_regulation MAP2K3 TNF 10788437 688684 hCG abrogated the *induced* activation of [mitogen activated protein kinase kinase] and c-Jun N-terminal kinase required for NF-kappaB and AP-1 , respectively . Positive_regulation MAP2K3 TNF 10843709 700186 Resveratrol also inhibited the induced *activation* of [mitogen activated protein kinase kinase] and c-Jun N-terminal kinase and abrogated TNF induced cytotoxicity and caspase activation . Positive_regulation MAP2K3 TNF 11149911 780455 mediated *activation* of [MEK/ERK] and EGR-1 can be blocked by adenoviral expression of a dominant negative mutant of IKK2 , whereas the VEGF signaling pathway is unaffected . Positive_regulation MAP2K3 TNF 11156586 780629 To clarify these issues , we examined the effect of NAC on *induced* activation of p38 MAP kinase , [MAP kinase kinase (MKK) 3] and MKK6 which are upstream regulators of p38 MAP kinase , and p38 MAP kinase mediated IL-8 production . Positive_regulation MAP2K3 TNF 14695331 1195163 [Phospho-MKK3] levels were low in medium treated FLS , but were rapidly *increased* by interleukin-1 and , although phospho-MKK6 levels only modestly increased . Positive_regulation MAP2K3 TNF 16452391 1547913 The Syk inhibitor also decreased *induced* [mitogen activated protein kinase kinase] ( MKK) 4 phosphorylation but not MKK3 and MKK6 phosphorylation , which is consistent with its selective sparing of p38 . Positive_regulation MAP2K3 TNF 19144181 2079123 Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by *induced* [MEK/ERK] signalling . Positive_regulation MAP2K3 TNF 19144181 2079131 *activates* [mitogen activated kinase kinase (MEK)/extracellular] regulated kinase (ERK) in chondrocytes ; Positive_regulation MAP2K3 TNF 19628074 2112819 and/or TGF-alpha stimulation *increased* [phospho-MEK] and phospho-ERK in cells transfected with TNFR1 siRNA . Positive_regulation MAP2K3 TNF 21320357 2393847 The effects of IL-1ß and on EPCR shedding in DU-145 cells are *mediated* by [MEK/ERK] 1/2 , JNK , and p38 MAPK signalling cascades . Positive_regulation MAP2K3 TNF 24151609 2859757 In our study , we found that a treatments *induce* [MEK] and AKT phosphorylation . Positive_regulation MAP2K3 TNF 8900184 393465 *Activation* of [mitogen activated protein kinase kinase] 6 by osmotic shock , , and H2O2 . Positive_regulation MAP2K3 TNF 9582369 504228 In addition , Mn-SOD blocked the *mediated* activation of activated protein-1 , stress activated c-Jun protein kinase , and [mitogen activated protein kinase kinase] . Positive_regulation MAP2K4 ANGPT1 12890486 1117306 Localization of Tie2 and phospholipase D in endothelial caveolae is involved in *induced* [MEK/ERK] phosphorylation and migration in endothelial cells . Positive_regulation MAP2K4 ANGPT1 12890486 1117427 Ang1 induced MEK/ERK activation was abrogated when PLD was inhibited , suggesting that PLD mediates induced [MEK/ERK] *activation* . Positive_regulation MAP2K4 ANGPT1 16000309 1452803 In addition , *induced* [SEK1] phosphorylation at Ser80 , suggesting the existence of an additional signal transduction pathway through which Ang1 attenuates JNK phosphorylation . Positive_regulation MAP2K4 CCND1 22579115 2609556 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated and Cyclin B1 proteins as well as *activation* of PI3K/Akt and [Raf/MEK/ERK] , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation MAP2K4 CD14 16879219 1593841 Lipopolysaccharide induced decreased protein S expression in liver cells is mediated by [MEK/ERK] signaling and NFkappaB *activation* : involvement of membrane bound and toll-like receptor-4 . Positive_regulation MAP2K4 CD14 16879219 1593863 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by [MEK/ERK] signaling and NFkappaB activation and that membrane bound and TLR-4 are *involved* in this mechanism . Positive_regulation MAP2K4 CLU 15857407 1400247 The [mitogen activated protein kinase kinase] and protein kinase C inhibitors PD98059 and H7 inhibited mediated *induction* of reactive nitrogen intermediate secretion from cultured microglia . Positive_regulation MAP2K4 CLU 19218870 2039544 Exogenous *stimulates* Ras dependent [Raf-1/mitogen activated protein kinase kinase] ( MEK ) /ERK activation . Positive_regulation MAP2K4 CTGF 15855807 1425621 TGF-beta1 induced connective tissue growth factor ( ) expression in human renal proximal tubule epithelial cells *requires* [Ras/MEK/ERK] and Smad signalling . Positive_regulation MAP2K4 EPHB2 10996792 733916 As in proliferating cells , activation during G0 *required* the MAPkinase kinase [MEK] and was partially dependent on cell adhesion . Positive_regulation MAP2K4 EPHB2 11304535 819983 However , cyclin E expression is ineffectual in rescuing these effects when ERK activation is blocked by treatment with PD98059 , a selective inhibitor of [MEK] *activation* of . Positive_regulation MAP2K4 EPHB2 12675684 1076707 In contrast , the *activation* of by constitutively active forms of [MAP kinase kinase (MEK)] was not inhibited , suggesting that the actions of SptP were mediated by Raf-1 . Positive_regulation MAP2K4 EPHB2 15304546 1322429 Furthermore , *activation* of by the coexpression of constitutively active [MAPKK/MEK] predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAP2K4 EPHB2 15843535 1398476 As in the classical pathway , BCR induced activation in the new , PI3K independent pathway *required* [MEK] and was reflected in c-Raf . Positive_regulation MAP2K4 EPHB2 15855657 1439595 Activation of ERK was attenuated by drugs that disassemble the actin cytoskeleton ( cytochalasin D , latrunculin B ) , and these compounds interfered with the *activation* of by [mitogen activated protein kinase kinase] ( MEK ) . Positive_regulation MAP2K4 EPHB2 17337598 1765827 A pharmacological inhibitor of MEK activity inhibits LPA stimulated WT Hic-5 cell migration and ERK phosphorylation , suggesting Hic-5 enhances migration via [MEK] *activation* of . Positive_regulation MAP2K4 EPHB2 18194435 1895322 Although [mitogen activated protein kinase kinase] ( MEK ) and extracellular signal regulated protein kinase ( ERK ) are activated by GW5074 , pharmacological inhibition of signaling by U0126 or PD98059 does not *reduce* neuroprotection suggesting that B-Raf signals through a non-canonical signaling pathway . Positive_regulation MAP2K4 EPHB2 22328534 2642861 PD98059 , [MEK] *inhibitor* , or U0126 , inhibitor , reduced SNU668 cell migration accompanying an increase in p-GSK-3a , ß-catenin and E-cadherin . Positive_regulation MAP2K4 EPHB2 22506069 2583979 Activations of [MEK] , ERK , and NF-?B pathways after CCL5 treatment were demonstrated , and CCL5 induced expression of integrin and migration activity was *inhibited* by the specific inhibitor and mutant of MEK , , and NF-?B cascades . Positive_regulation MAP2K4 EPHB2 22740332 2715448 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Positive_regulation MAP2K4 EPHB2 22785235 2691813 TRH induced CRE promoter was inhibited by mitogen activated protein kinase ( MEK ) inhibitor and was *increased* by overexpression of [MEK kinase (MEKK)] . Positive_regulation MAP2K4 EPHB2 22892241 2666341 However , unlike ( V600E ) Braf , pathway activation was mediated by both Craf and Braf , and ATP-competitive RAF inhibitors *induced* paradoxical [Mek/Erk] pathway activation . Positive_regulation MAP2K4 EPHB2 7838428 286300 The protein expression profiles were almost equivalent , but the MEK expression was slightly advanced , suggesting that the observed up-regulation of [MEK] was not *due* to that of . Positive_regulation MAP2K4 EPHB2 8226933 235475 Phosphorylation of [MEK] is also *stimulated* by . Positive_regulation MAP2K4 ID1 14742319 1250769 *induced* [Raf/MEK] pathway activation is essential for its protective role against taxol induced apoptosis in nasopharyngeal carcinoma cells . Positive_regulation MAP2K4 IFI27 10951574 723767 Inhibition of [MEK] activation completely abrogated OSM and IL-6 *induced* p27kip1 accumulation , while expression of dominant negative STAT5 decreased the OSM and IL-6 mediated inhibition of DNA-synthesis and partially inhibited accumulation . Positive_regulation MAP2K4 IL1B 10593906 572874 In previous studies we demonstrated that can *activate* [MKK4/SEK1] , MKK3 , and MKK6 in renal mesangial cells ; Positive_regulation MAP2K4 IL1B 11179516 784775 We found that *induced* ERK phosphorylation , PD153035 and [MEK] inhibitor PD98059 blocked IL-1 beta induced ERK activity . Positive_regulation MAP2K4 IL1B 16043966 1459733 Western blot analysis demonstrated that *increased* the activation of phosphorylated [MEK] and p38 MAPK in GH3 cells . Positive_regulation MAP2K4 IL1B 9786861 540952 Furthermore , our experiments confirm that *activates* [MAP kinase kinase-4 (MKK4)/SEK1] , MKK3 , and MKK6 in renal mesangial cells . Positive_regulation MAP2K4 PLAU 17681345 1822239 These latter effects were mediated by induced *activation* of the mitogen activated protein kinase/extracellular signal regulated kinase ( [MEK] ) . Positive_regulation MAP2K4 PLAU 22155455 2542707 uPA downregulated PON1 gene expression via inactivation of peroxisome proliferator activated receptor-? ( PPAR? ) activity , and this effect was dependent on mediated [mitogen activated protein kinase kinase] *activation* . Positive_regulation MAP2K4 PLAU 22155455 2542729 Mechanistic studies showed that *enhanced* [mitogen activated protein kinase kinase-PPAR?] interaction , resulting in PPAR? nuclear export to the cytosol . Positive_regulation MAP2K4 STK39 10924861 718604 Genistein , a tyrosine kinase inhibitor , H7 , a inhibitor , and PD 98059 , a [MEK] *inhibitor* , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation MAP2K4 STK39 7623807 315993 The Raf-1 functions downstream from Ras to *activate* [mitogen activated protein kinase kinase] , but the mechanisms of Raf-1 activation are incompletely understood . Positive_regulation MAP2K4 TNF 10075082 594855 Beta-lapachone also abolished *induced* activation of AP-1 , c-Jun N-terminal kinase , and [mitogen activated protein kinase kinase] ( MAPKK or MEK ) . Positive_regulation MAP2K4 TNF 10439045 635252 gamma-GCS also abolished the activation of AP-1 induced by TNF and inhibited induced *activation* of JNK and [mitogen activated protein kinase kinase] . Positive_regulation MAP2K4 TNF 10586080 571814 Silymarin also inhibited the *induced* activation of [mitogen activated protein kinase kinase] and c-Jun N-terminal kinase and abrogated TNF induced cytotoxicity and caspase activation . Positive_regulation MAP2K4 TNF 10788437 688685 hCG abrogated the *induced* activation of [mitogen activated protein kinase kinase] and c-Jun N-terminal kinase required for NF-kappaB and AP-1 , respectively . Positive_regulation MAP2K4 TNF 10843709 700187 Resveratrol also inhibited the *induced* activation of [mitogen activated protein kinase kinase] and c-Jun N-terminal kinase and abrogated TNF induced cytotoxicity and caspase activation . Positive_regulation MAP2K4 TNF 11149911 780457 mediated *activation* of [MEK/ERK] and EGR-1 can be blocked by adenoviral expression of a dominant negative mutant of IKK2 , whereas the VEGF signaling pathway is unaffected . Positive_regulation MAP2K4 TNF 12186863 997707 Inhibition of p38 MAPK by SB 203580 and M 39 resulted in significant augmentation of *induced* JNK and [MKK4] ( but not MKK7 or MEKK1 ) activation , whereas prior exposure to a p38 activating agent ( platelet activating factor ) diminished the TNFalpha induced JNK response . Positive_regulation MAP2K4 TNF 16452391 1547914 The Syk inhibitor also decreased *induced* [mitogen activated protein kinase kinase] ( MKK) 4 phosphorylation but not MKK3 and MKK6 phosphorylation , which is consistent with its selective sparing of p38 . Positive_regulation MAP2K4 TNF 17548155 1762594 Additionally , the same treatment inhibited *induced* phosphorylation of [MKK4] and the subsequent activation of the JNK-AP-1 pathway . Positive_regulation MAP2K4 TNF 19026990 2022788 Myricetin inhibited *induced* [MKK4] activity and bound glutathione S-transferase-MKK4 directly by competing with ATP . Positive_regulation MAP2K4 TNF 19144181 2079124 Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by *induced* [MEK/ERK] signalling . Positive_regulation MAP2K4 TNF 19144181 2079132 *activates* [mitogen activated kinase kinase (MEK)/extracellular] regulated kinase (ERK) in chondrocytes ; Positive_regulation MAP2K4 TNF 19628074 2112820 and/or TGF-alpha stimulation *increased* [phospho-MEK] and phospho-ERK in cells transfected with TNFR1 siRNA . Positive_regulation MAP2K4 TNF 21320357 2393849 The effects of IL-1ß and on EPCR shedding in DU-145 cells are *mediated* by [MEK/ERK] 1/2 , JNK , and p38 MAPK signalling cascades . Positive_regulation MAP2K4 TNF 24151609 2859758 In our study , we found that a treatments *induce* [MEK] and AKT phosphorylation . Positive_regulation MAP2K4 TNF 8900184 393466 *Activation* of [mitogen activated protein kinase kinase] 6 by osmotic shock , , and H2O2 . Positive_regulation MAP2K4 TNF 9384583 466379 MKK7 is activated strongly by tumour necrosis factor alpha (TNFalpha) as well as by environmental stresses , whereas [SEK1/MKK4] is not *activated* by . Positive_regulation MAP2K4 TNF 9582369 504229 In addition , Mn-SOD blocked the mediated *activation* of activated protein-1 , stress activated c-Jun protein kinase , and [mitogen activated protein kinase kinase] . Positive_regulation MAP2K5 ANGPT1 12890486 1117314 Localization of Tie2 and phospholipase D in endothelial caveolae is involved in *induced* [MEK/ERK] phosphorylation and migration in endothelial cells . Positive_regulation MAP2K5 ANGPT1 12890486 1117434 Ang1 induced MEK/ERK activation was abrogated when PLD was inhibited , suggesting that PLD mediates *induced* [MEK/ERK] activation . Positive_regulation MAP2K5 CCND1 22579115 2609557 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated and Cyclin B1 proteins as well as *activation* of PI3K/Akt and [Raf/MEK/ERK] , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation MAP2K5 CD14 16879219 1593842 Lipopolysaccharide induced decreased protein S expression in liver cells is mediated by [MEK/ERK] signaling and NFkappaB *activation* : involvement of membrane bound and toll-like receptor-4 . Positive_regulation MAP2K5 CD14 16879219 1593865 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by [MEK/ERK] signaling and NFkappaB activation and that membrane bound and TLR-4 are *involved* in this mechanism . Positive_regulation MAP2K5 CLU 15857407 1400248 The [mitogen activated protein kinase kinase] and protein kinase C inhibitors PD98059 and H7 inhibited mediated *induction* of reactive nitrogen intermediate secretion from cultured microglia . Positive_regulation MAP2K5 CLU 19218870 2039548 Exogenous *stimulates* Ras dependent [Raf-1/mitogen activated protein kinase kinase] ( MEK ) /ERK activation . Positive_regulation MAP2K5 CTGF 15855807 1425622 TGF-beta1 induced connective tissue growth factor ( ) expression in human renal proximal tubule epithelial cells *requires* [Ras/MEK/ERK] and Smad signalling . Positive_regulation MAP2K5 EPHB2 10996792 733917 As in proliferating cells , activation during G0 *required* the MAPkinase kinase [MEK] and was partially dependent on cell adhesion . Positive_regulation MAP2K5 EPHB2 11304535 819984 However , cyclin E expression is ineffectual in rescuing these effects when ERK activation is blocked by treatment with PD98059 , a selective inhibitor of [MEK] *activation* of . Positive_regulation MAP2K5 EPHB2 12675684 1076708 In contrast , the *activation* of by constitutively active forms of [MAP kinase kinase (MEK)] was not inhibited , suggesting that the actions of SptP were mediated by Raf-1 . Positive_regulation MAP2K5 EPHB2 15304546 1322443 Furthermore , *activation* of by the coexpression of constitutively active [MAPKK/MEK] predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAP2K5 EPHB2 15843535 1398478 As in the classical pathway , BCR induced activation in the new , PI3K independent pathway *required* [MEK] and was reflected in c-Raf . Positive_regulation MAP2K5 EPHB2 15855657 1439596 Activation of ERK was attenuated by drugs that disassemble the actin cytoskeleton ( cytochalasin D , latrunculin B ) , and these compounds interfered with the *activation* of by [mitogen activated protein kinase kinase] ( MEK ) . Positive_regulation MAP2K5 EPHB2 17337598 1765828 A pharmacological inhibitor of MEK activity inhibits LPA stimulated WT Hic-5 cell migration and ERK phosphorylation , suggesting Hic-5 enhances migration via [MEK] *activation* of . Positive_regulation MAP2K5 EPHB2 18194435 1895323 Although [mitogen activated protein kinase kinase] ( MEK ) and extracellular signal regulated protein kinase ( ERK ) are activated by GW5074 , pharmacological inhibition of signaling by U0126 or PD98059 does not *reduce* neuroprotection suggesting that B-Raf signals through a non-canonical signaling pathway . Positive_regulation MAP2K5 EPHB2 22328534 2642862 PD98059 , [MEK] *inhibitor* , or U0126 , inhibitor , reduced SNU668 cell migration accompanying an increase in p-GSK-3a , ß-catenin and E-cadherin . Positive_regulation MAP2K5 EPHB2 22506069 2583980 Activations of [MEK] , ERK , and NF-?B pathways after CCL5 treatment were demonstrated , and CCL5 induced expression of integrin and migration activity was *inhibited* by the specific inhibitor and mutant of MEK , , and NF-?B cascades . Positive_regulation MAP2K5 EPHB2 22740332 2715449 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Positive_regulation MAP2K5 EPHB2 22785235 2691827 TRH induced CRE promoter was inhibited by mitogen activated protein kinase ( MEK ) inhibitor and was *increased* by overexpression of [MEK kinase (MEKK)] . Positive_regulation MAP2K5 EPHB2 22892241 2666343 However , unlike ( V600E ) Braf , pathway activation was mediated by both Craf and Braf , and ATP-competitive RAF inhibitors *induced* paradoxical [Mek/Erk] pathway activation . Positive_regulation MAP2K5 EPHB2 7838428 286301 The protein expression profiles were almost equivalent , but the MEK expression was slightly advanced , suggesting that the observed up-regulation of [MEK] was not *due* to that of . Positive_regulation MAP2K5 EPHB2 8226933 235476 Phosphorylation of [MEK] is also *stimulated* by . Positive_regulation MAP2K5 ID1 14742319 1250770 induced [Raf/MEK] pathway *activation* is essential for its protective role against taxol induced apoptosis in nasopharyngeal carcinoma cells . Positive_regulation MAP2K5 IFI27 10951574 723770 Inhibition of [MEK] activation completely abrogated OSM and IL-6 *induced* p27kip1 accumulation , while expression of dominant negative STAT5 decreased the OSM and IL-6 mediated inhibition of DNA-synthesis and partially inhibited accumulation . Positive_regulation MAP2K5 IL1B 11179516 784776 We found that *induced* ERK phosphorylation , PD153035 and [MEK] inhibitor PD98059 blocked IL-1 beta induced ERK activity . Positive_regulation MAP2K5 IL1B 16043966 1459734 Western blot analysis demonstrated that *increased* the activation of phosphorylated [MEK] and p38 MAPK in GH3 cells . Positive_regulation MAP2K5 PLAU 17681345 1822240 These latter effects were mediated by *induced* activation of the mitogen activated protein kinase/extracellular signal regulated kinase ( [MEK] ) . Positive_regulation MAP2K5 PLAU 22155455 2542708 uPA downregulated PON1 gene expression via inactivation of peroxisome proliferator activated receptor-? ( PPAR? ) activity , and this effect was dependent on mediated [mitogen activated protein kinase kinase] *activation* . Positive_regulation MAP2K5 PLAU 22155455 2542730 Mechanistic studies showed that *enhanced* [mitogen activated protein kinase kinase-PPAR?] interaction , resulting in PPAR? nuclear export to the cytosol . Positive_regulation MAP2K5 STK39 10924861 718619 Genistein , a tyrosine kinase inhibitor , H7 , a inhibitor , and PD 98059 , a [MEK] *inhibitor* , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation MAP2K5 STK39 7623807 316009 The Raf-1 functions downstream from Ras to *activate* [mitogen activated protein kinase kinase] , but the mechanisms of Raf-1 activation are incompletely understood . Positive_regulation MAP2K5 TNF 10075082 594856 Beta-lapachone also abolished *induced* activation of AP-1 , c-Jun N-terminal kinase , and [mitogen activated protein kinase kinase] ( MAPKK or MEK ) . Positive_regulation MAP2K5 TNF 10439045 635253 gamma-GCS also abolished the activation of AP-1 induced by TNF and inhibited *induced* activation of JNK and [mitogen activated protein kinase kinase] . Positive_regulation MAP2K5 TNF 10586080 571815 Silymarin also inhibited the induced *activation* of [mitogen activated protein kinase kinase] and c-Jun N-terminal kinase and abrogated TNF induced cytotoxicity and caspase activation . Positive_regulation MAP2K5 TNF 10788437 688686 hCG abrogated the induced *activation* of [mitogen activated protein kinase kinase] and c-Jun N-terminal kinase required for NF-kappaB and AP-1 , respectively . Positive_regulation MAP2K5 TNF 10843709 700188 Resveratrol also inhibited the induced *activation* of [mitogen activated protein kinase kinase] and c-Jun N-terminal kinase and abrogated TNF induced cytotoxicity and caspase activation . Positive_regulation MAP2K5 TNF 11149911 780459 mediated *activation* of [MEK/ERK] and EGR-1 can be blocked by adenoviral expression of a dominant negative mutant of IKK2 , whereas the VEGF signaling pathway is unaffected . Positive_regulation MAP2K5 TNF 16452391 1547915 The Syk inhibitor also decreased *induced* [mitogen activated protein kinase kinase] ( MKK) 4 phosphorylation but not MKK3 and MKK6 phosphorylation , which is consistent with its selective sparing of p38 . Positive_regulation MAP2K5 TNF 19144181 2079125 Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by *induced* [MEK/ERK] signalling . Positive_regulation MAP2K5 TNF 19144181 2079133 *activates* [mitogen activated kinase kinase (MEK)/extracellular] regulated kinase (ERK) in chondrocytes ; Positive_regulation MAP2K5 TNF 19628074 2112821 and/or TGF-alpha stimulation *increased* [phospho-MEK] and phospho-ERK in cells transfected with TNFR1 siRNA . Positive_regulation MAP2K5 TNF 21320357 2393851 The effects of IL-1ß and on EPCR shedding in DU-145 cells are *mediated* by [MEK/ERK] 1/2 , JNK , and p38 MAPK signalling cascades . Positive_regulation MAP2K5 TNF 24151609 2859759 In our study , we found that a treatments *induce* [MEK] and AKT phosphorylation . Positive_regulation MAP2K5 TNF 8900184 393467 *Activation* of [mitogen activated protein kinase kinase] 6 by osmotic shock , , and H2O2 . Positive_regulation MAP2K5 TNF 9582369 504230 In addition , Mn-SOD blocked the *mediated* activation of activated protein-1 , stress activated c-Jun protein kinase , and [mitogen activated protein kinase kinase] . Positive_regulation MAP2K6 ABCB1 20236757 2272934 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2 , Bcl-xL and XIAP ) , as well as *activation* of [Ras/MEK/ERK] and PI3K/Akt signaling . Positive_regulation MAP2K6 ABCB1 21742513 2484270 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-8 is associated with increased expression of both multidrug resistance related genes ( ) and apoptosis inhibitory proteins ( Bcl-2 , Bcl-xL , and XIAP ) , as well as *activation* of PI3K/Akt and [Ras/MEK/ERK] signaling . Positive_regulation MAP2K6 ABL1 10570156 568121 Our study suggests that c-Abl is required for DNA damage induced MKK6 and p38 activation , and that *activation* of [MKK6] by is required for c-Abl induced apoptosis but not c-Abl induced cell cycle arrest . Positive_regulation MAP2K6 ADCY1 17877640 1796625 In one clone ( PC47 ) , ICP10PK inhibited caspase-3 activation through up-regulation/stabilization of , *activation* of PKA and [MEK] , and the convergence of the two pathways on extracellular signal regulated kinase activation . Positive_regulation MAP2K6 ADCY10 17877640 1796624 In one clone ( PC47 ) , ICP10PK inhibited caspase-3 activation through up-regulation/stabilization of , *activation* of PKA and [MEK] , and the convergence of the two pathways on extracellular signal regulated kinase activation . Positive_regulation MAP2K6 ADCY2 17877640 1796626 In one clone ( PC47 ) , ICP10PK inhibited caspase-3 activation through up-regulation/stabilization of , *activation* of PKA and [MEK] , and the convergence of the two pathways on extracellular signal regulated kinase activation . Positive_regulation MAP2K6 ADCY3 17877640 1796627 In one clone ( PC47 ) , ICP10PK inhibited caspase-3 activation through up-regulation/stabilization of , *activation* of PKA and [MEK] , and the convergence of the two pathways on extracellular signal regulated kinase activation . Positive_regulation MAP2K6 ADCY4 17877640 1796628 In one clone ( PC47 ) , ICP10PK inhibited caspase-3 activation through up-regulation/stabilization of , *activation* of PKA and [MEK] , and the convergence of the two pathways on extracellular signal regulated kinase activation . Positive_regulation MAP2K6 ADCY5 17877640 1796629 In one clone ( PC47 ) , ICP10PK inhibited caspase-3 activation through up-regulation/stabilization of , *activation* of PKA and [MEK] , and the convergence of the two pathways on extracellular signal regulated kinase activation . Positive_regulation MAP2K6 ADCY6 17877640 1796630 In one clone ( PC47 ) , ICP10PK inhibited caspase-3 activation through up-regulation/stabilization of , *activation* of PKA and [MEK] , and the convergence of the two pathways on extracellular signal regulated kinase activation . Positive_regulation MAP2K6 ADCY7 17877640 1796631 In one clone ( PC47 ) , ICP10PK inhibited caspase-3 activation through up-regulation/stabilization of , *activation* of PKA and [MEK] , and the convergence of the two pathways on extracellular signal regulated kinase activation . Positive_regulation MAP2K6 ADCY8 17877640 1796632 In one clone ( PC47 ) , ICP10PK inhibited caspase-3 activation through up-regulation/stabilization of , *activation* of PKA and [MEK] , and the convergence of the two pathways on extracellular signal regulated kinase activation . Positive_regulation MAP2K6 ADCY9 17877640 1796633 In one clone ( PC47 ) , ICP10PK inhibited caspase-3 activation through up-regulation/stabilization of , *activation* of PKA and [MEK] , and the convergence of the two pathways on extracellular signal regulated kinase activation . Positive_regulation MAP2K6 AFF1 20362031 2261048 We further showed that endogenous MEK is phosphorylated in a MLL-AF4 expressing leukemia cell line , whereas depletion of by small interfering RNA *reduced* the [phospho-MEK] level . Positive_regulation MAP2K6 AKT1 12181443 977680 activation induced by lysophosphatidic acid and sphingosine-1-phosphate *requires* both [mitogen activated protein kinase kinase] and p38 mitogen activated protein kinase and is cell-line specific . Positive_regulation MAP2K6 AKT1 12181443 977790 However , epidermal growth factor , thrombin , and endothelin-1 stimulated S473 phosphorylation *require* p38 but not [MEK] . Positive_regulation MAP2K6 AKT1 12527803 1048380 *dependent* phosphorylation of serine 1179 and [mitogen activated protein kinase kinase/extracellular] signal regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide . Positive_regulation MAP2K6 AKT1 12527803 1048465 In summary , H ( 2 ) O ( 2 ) causes endothelial NO* release mediated by cooperative effects between PI <3-kinase/Akt> dependent eNOS serine 1179 phosphorylation and *activation* of [MEK/ERK1/2] . Positive_regulation MAP2K6 AKT1 15475007 1319169 For example , inhibitors of [MEK] and phosphatidylinositol-3-kinase *induced* p27 expression primarily in G1 phase , while inhibitors of activity stimulated these levels primarily in S phase . Positive_regulation MAP2K6 AKT1 15618457 1387780 The PI3K inhibitors wortmannin and LY-294002 and an inhibitor , 1-L-6-hydroxymethyl-chiro-inositol 2- ( R ) -2-O-methyl-3-O-octadecylcarbonate , but not a [mitogen activated protein kinase kinase] *inhibitor* PD-98059 , blocked isoproterenol mediated eosinophil survival . Positive_regulation MAP2K6 AKT1 18224693 1884251 These results imply that cisplatin induced [MEK/ERK] activation appears to mediate apoptotic cell death , but that constitutively activated and/or ERK pathway may *mediate* resistance to cisplatin in NSCLC cells . Positive_regulation MAP2K6 AKT1 20561929 2290116 The vasoprotective effect of JP05 through the activation of *dependent* eNOS and [MEK/ERK] pathways in brain endothelial cells . Positive_regulation MAP2K6 AKT1 23701950 2806149 In contrast , activity was *sufficient* to induce not only B-Raf phosphorylation but also [MEK/ERK] activation in the hormone refractory LNCaP variant , C4-2 . Positive_regulation MAP2K6 AKT1 24652289 2934725 Nearly all IRS1 Ser(P)/Thr ( P ) residues were stimulated by insulin and significantly suppressed by PI3K inhibition ; fewer were suppressed by or mTOR inhibition , and none were *suppressed* by [MEK] inhibition . Positive_regulation MAP2K6 AKT2 12181443 977681 activation induced by lysophosphatidic acid and sphingosine-1-phosphate *requires* both [mitogen activated protein kinase kinase] and p38 mitogen activated protein kinase and is cell-line specific . Positive_regulation MAP2K6 AKT2 12181443 977791 However , epidermal growth factor , thrombin , and endothelin-1 stimulated S473 phosphorylation *require* p38 but not [MEK] . Positive_regulation MAP2K6 AKT2 12527803 1048381 *dependent* phosphorylation of serine 1179 and [mitogen activated protein kinase kinase/extracellular] signal regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide . Positive_regulation MAP2K6 AKT2 12527803 1048466 In summary , H ( 2 ) O ( 2 ) causes endothelial NO* release mediated by cooperative effects between PI <3-kinase/Akt> *dependent* eNOS serine 1179 phosphorylation and activation of [MEK/ERK1/2] . Positive_regulation MAP2K6 AKT2 15475007 1319170 For example , inhibitors of [MEK] and phosphatidylinositol-3-kinase *induced* p27 expression primarily in G1 phase , while inhibitors of activity stimulated these levels primarily in S phase . Positive_regulation MAP2K6 AKT2 15618457 1387781 The PI3K inhibitors wortmannin and LY-294002 and an inhibitor , 1-L-6-hydroxymethyl-chiro-inositol 2- ( R ) -2-O-methyl-3-O-octadecylcarbonate , but not a [mitogen activated protein kinase kinase] *inhibitor* PD-98059 , blocked isoproterenol mediated eosinophil survival . Positive_regulation MAP2K6 AKT2 20561929 2290117 The vasoprotective effect of JP05 through the activation of *dependent* eNOS and [MEK/ERK] pathways in brain endothelial cells . Positive_regulation MAP2K6 AKT2 23701950 2806150 In contrast , activity was *sufficient* to induce not only B-Raf phosphorylation but also [MEK/ERK] activation in the hormone refractory LNCaP variant , C4-2 . Positive_regulation MAP2K6 AKT2 24652289 2934726 Nearly all IRS1 Ser(P)/Thr ( P ) residues were stimulated by insulin and significantly suppressed by PI3K inhibition ; fewer were suppressed by or mTOR inhibition , and none were *suppressed* by [MEK] inhibition . Positive_regulation MAP2K6 AKT3 12181443 977682 activation induced by lysophosphatidic acid and sphingosine-1-phosphate *requires* both [mitogen activated protein kinase kinase] and p38 mitogen activated protein kinase and is cell-line specific . Positive_regulation MAP2K6 AKT3 12181443 977792 However , epidermal growth factor , thrombin , and endothelin-1 stimulated S473 phosphorylation *require* p38 but not [MEK] . Positive_regulation MAP2K6 AKT3 12527803 1048382 *dependent* phosphorylation of serine 1179 and [mitogen activated protein kinase kinase/extracellular] signal regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide . Positive_regulation MAP2K6 AKT3 12527803 1048467 In summary , H ( 2 ) O ( 2 ) causes endothelial NO* release mediated by cooperative effects between PI <3-kinase/Akt> dependent eNOS serine 1179 phosphorylation and *activation* of [MEK/ERK1/2] . Positive_regulation MAP2K6 AKT3 15475007 1319171 For example , inhibitors of [MEK] and phosphatidylinositol-3-kinase *induced* p27 expression primarily in G1 phase , while inhibitors of activity stimulated these levels primarily in S phase . Positive_regulation MAP2K6 AKT3 15618457 1387782 The PI3K inhibitors wortmannin and LY-294002 and an inhibitor , 1-L-6-hydroxymethyl-chiro-inositol 2- ( R ) -2-O-methyl-3-O-octadecylcarbonate , but not a [mitogen activated protein kinase kinase] *inhibitor* PD-98059 , blocked isoproterenol mediated eosinophil survival . Positive_regulation MAP2K6 AKT3 20561929 2290118 The vasoprotective effect of JP05 through the activation of *dependent* eNOS and [MEK/ERK] pathways in brain endothelial cells . Positive_regulation MAP2K6 AKT3 23701950 2806151 In contrast , activity was *sufficient* to induce not only B-Raf phosphorylation but also [MEK/ERK] activation in the hormone refractory LNCaP variant , C4-2 . Positive_regulation MAP2K6 AKT3 24652289 2934727 Nearly all IRS1 Ser(P)/Thr ( P ) residues were stimulated by insulin and significantly suppressed by PI3K inhibition ; fewer were suppressed by or mTOR inhibition , and none were *suppressed* by [MEK] inhibition . Positive_regulation MAP2K6 AKTIP 22771629 2639579 *induces* the activation of PI3K/AKT and [Raf/MEK/ERK] signaling pathways . Positive_regulation MAP2K6 ALK 16909118 1692155 The *induced* [MEK/ERK] activation is independent of c-Raf as evidenced by the lack of MEK1/2 and ERK1/2 phosphorylation upon c-Raf inactivation by two different inhibitors , RI and ZM336372 , and by its siRNA mediated depletion . Positive_regulation MAP2K6 ANGPT1 12890486 1117322 Localization of Tie2 and phospholipase D in endothelial caveolae is involved in *induced* [MEK/ERK] phosphorylation and migration in endothelial cells . Positive_regulation MAP2K6 ANGPT1 12890486 1117441 induced [MEK/ERK] *activation* was abrogated when PLD was inhibited , suggesting that PLD mediates Ang1 induced MEK/ERK activation . Positive_regulation MAP2K6 ANGPT2 16513650 1555032 The use of pharmacological inhibitors that inhibit the *activation* of [MEK] by revealed that phosphorylation of p65 on serine 536 did not require the MEK-ERK-RSK signaling pathway . Positive_regulation MAP2K6 ANGPT2 16595708 1544622 Furthermore , stimulation of the cells with *increased* both phosphorylation of p38 MAPK and [MAP kinase kinase 3/6] ( MKK3/6 ) . Positive_regulation MAP2K6 ANGPT2 9732408 530638 In cultured rat aortic smooth muscle cells , Ang II ( 0.1-1000 nM ) stimulated concentration dependent tyrosyl-phosphorylation of the extracellular signal regulated kinase ( Erk ) mitogen activated protein kinases ( maximal stimulation , fold basal : Erk-1 = 17-fold , Erk-2 = 3-fold ) , indicating that can *activate* [MEK] . Positive_regulation MAP2K6 ANGPT2 9732408 530645 Thus , while can *stimulate* both [MEK] activation and vascular contraction via interaction with AT1 receptors , stimulation of MEK does not appear to be important for Ang II-induced contraction . Positive_regulation MAP2K6 ANXA6 12629037 1072251 In other groups , L-NAME was also used in combination with a inhibitor ( rapamycin ) , a [MEK] *inhibitor* ( PD98059 ) , and hydralazine . Positive_regulation MAP2K6 APBB1IP 22946047 2710285 Our data suggest that integrin triggered , *dependent* [MEK] activation represents a key feedback event required for efficient FA disassembly , which could help explain the role of RIAM in cell migration and invasion . Positive_regulation MAP2K6 APPL1 17000777 1640947 Reduction of or GIPC1 protein levels *suppressed* nerve growth factor (NGF) dependent [MEK] , extracellular signal regulated kinase , and Akt activation and neurite outgrowth in PC12 cells . Positive_regulation MAP2K6 ARAF 7565795 328441 By contrast , the activation of delta : ER *led* to a weak activation of [MEK] and the p42/p44 MAP kinases . Positive_regulation MAP2K6 ARF6 19642173 2150018 This stimulation was caused by increased transcription of and by *activation* of the [MEK/extracellular] signal regulated kinase 1 and 2 ( ERK1/2 ) and PI3K signaling pathways . Positive_regulation MAP2K6 ATF3 15731359 1403026 We report that : 1 ) insulin induced transcription of , Pip92 , and Insig-1 *required* [MEK-ERK] activation ; Positive_regulation MAP2K6 AVP 17113946 1651178 Radioimmunoassy results showed that *increased* leucine-enkephalin ( L-Ek ) , [methionine-enkephalin (M-Ek)] , beta-endorphin ( beta-Ep ) rather than dynorphin A ( 1-13 ) ( DynA ( 1-13 ) ) concentrations in PAG slice culture liquid , and V ( 2 ) receptor antagonist : d ( CH ( 2 ) ) ( 5 ) [ D-Ile ( 2 ) , Ile ( 4 ) , Ala ( 9 ) -NH ( 2 ) ] AVP decreased L-Ek , M-Ek and beta-Ep , not DynA ( 1-13 ) concentrations in PAG slice culture liquid in a dose dependent manner , but V ( 1 ) receptor antagonist : d ( CH ( 2 ) ) ( 5 ) Tyr ( Me ) AVP did not change these peptide concentrations in PAG slice culture liquid . Positive_regulation MAP2K6 BCL10 20236757 2272936 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2 , and XIAP ) , as well as *activation* of [Ras/MEK/ERK] and PI3K/Akt signaling . Positive_regulation MAP2K6 BCL10 21742513 2484272 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-8 is associated with increased expression of both multidrug resistance related genes ( MDR1 ) and apoptosis inhibitory proteins ( Bcl-2 , , and XIAP ) , as well as *activation* of PI3K/Akt and [Ras/MEK/ERK] signaling . Positive_regulation MAP2K6 BCL2 20236757 2272937 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2 , and XIAP ) , as well as *activation* of [Ras/MEK/ERK] and PI3K/Akt signaling . Positive_regulation MAP2K6 BCL2 21742513 2484273 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-8 is associated with increased expression of both multidrug resistance related genes ( MDR1 ) and apoptosis inhibitory proteins ( Bcl-2 , , and XIAP ) , as well as *activation* of PI3K/Akt and [Ras/MEK/ERK] signaling . Positive_regulation MAP2K6 BCL3 20236757 2272938 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2 , and XIAP ) , as well as *activation* of [Ras/MEK/ERK] and PI3K/Akt signaling . Positive_regulation MAP2K6 BCL3 21742513 2484274 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-8 is associated with increased expression of both multidrug resistance related genes ( MDR1 ) and apoptosis inhibitory proteins ( Bcl-2 , , and XIAP ) , as well as *activation* of PI3K/Akt and [Ras/MEK/ERK] signaling . Positive_regulation MAP2K6 BCL5 20236757 2272931 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2 , and XIAP ) , as well as *activation* of [Ras/MEK/ERK] and PI3K/Akt signaling . Positive_regulation MAP2K6 BCL5 21742513 2484267 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-8 is associated with increased expression of both multidrug resistance related genes ( MDR1 ) and apoptosis inhibitory proteins ( Bcl-2 , , and XIAP ) , as well as *activation* of PI3K/Akt and [Ras/MEK/ERK] signaling . Positive_regulation MAP2K6 BCL6 20236757 2272932 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2 , and XIAP ) , as well as *activation* of [Ras/MEK/ERK] and PI3K/Akt signaling . Positive_regulation MAP2K6 BCL6 21742513 2484268 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-8 is associated with increased expression of both multidrug resistance related genes ( MDR1 ) and apoptosis inhibitory proteins ( Bcl-2 , , and XIAP ) , as well as *activation* of PI3K/Akt and [Ras/MEK/ERK] signaling . Positive_regulation MAP2K6 BCL9 20236757 2272933 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2 , and XIAP ) , as well as *activation* of [Ras/MEK/ERK] and PI3K/Akt signaling . Positive_regulation MAP2K6 BCL9 21742513 2484269 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-8 is associated with increased expression of both multidrug resistance related genes ( MDR1 ) and apoptosis inhibitory proteins ( Bcl-2 , , and XIAP ) , as well as *activation* of PI3K/Akt and [Ras/MEK/ERK] signaling . Positive_regulation MAP2K6 BCR 15843535 1398479 As in the classical pathway , induced ERK activation in the new , PI3K independent pathway *required* [MEK] and was reflected in c-Raf . Positive_regulation MAP2K6 BDNF 10648867 662308 These results thus suggest that both expressions of GABA(A) receptor subunits *require* the activation of [MEK] and the mitogen activated protein kinase (MAPK) pathway . Positive_regulation MAP2K6 BDNF 17306467 1705187 The effects of were *mediated* by receptor tyrosine kinase B (TrkB) and [mitogen activated protein kinase kinase] ( MEK ) activation since culturing neurons with either ( 9S,10R,12R ) -2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo [ 1,2,3-fg : 3',2',1'- kl ] pyrrolo [ 3,4-i ] [ 1,6 ] benzodiazocine-10-carboxylic acid methyl ester ( K252a ) or 2- ( 2-amino-3-methoxyphenyl ) -4H-1-benzopyran-4-one ( PD98059 ) blocked the augmentation in synaptic activity induced by the neurotrophin . Positive_regulation MAP2K6 BDNF 24260264 2869574 Our data indicate that overexpressing SH2B1ß enhances *induced* [MEK-ERK1/2] , and PI3K-AKT signaling pathways . Positive_regulation MAP2K6 BPNT1 15731359 1403024 We report that : 1 ) insulin induced transcription of ATF-3 , , and Insig-1 *required* [MEK-ERK] activation ; Positive_regulation MAP2K6 BRAF 11296228 801478 [MEK/ERK] activation is normal in Raf-1-deficient cells and embryos , and is probably *mediated* by . Positive_regulation MAP2K6 BRAF 16815849 1606068 We and others have previously shown that cyclin D1 is up-regulated in melanoma cells through adhesion independent [MEK-ERK1/2] signaling *initiated* by mutant . Positive_regulation MAP2K6 BRAF 16858395 1600489 Thus , we propose that the hitherto unidentified function of the B-Raf amino-terminal region is to mediate calcium dependent activation of and the following [MEK] *activation* , which may occur in the absence of Ras activation . Positive_regulation MAP2K6 BRAF 19835659 2154958 In addition , in order to investigate whether [MEK] is *regulated* by , we examined the B-Raf and MEK interaction . Positive_regulation MAP2K6 BRAF 21441910 2417154 Furthermore , KSR2-BRAF heterodimerization results in an increase of *induced* [MEK] phosphorylation via the KSR2 mediated relay of a signal from BRAF to release the activation segment of MEK for phosphorylation . Positive_regulation MAP2K6 BRAF 22892241 2666344 However , unlike ( V600E ) Braf , Mek/Erk pathway activation was mediated by both Craf and , and ATP-competitive RAF inhibitors *induced* paradoxical [Mek/Erk] pathway activation . Positive_regulation MAP2K6 BRAF 23020132 2694470 To address this problem , we conducted a phase 1 and 2 trial of combined treatment with dabrafenib , a selective inhibitor , and trametinib , a selective MAPK kinase ( [MEK] ) *inhibitor* . Positive_regulation MAP2K6 BRAF 25037257 2948649 Dermatologic adverse events to chemotherapeutic agents , Part 2 : inhibitors , [MEK] *inhibitors* , and ipilimumab . Positive_regulation MAP2K6 BRAF 25219500 2958306 ( V600E ) *increases* [BRAF/MEK/ERK] signaling resulting in phosphorylation and elevated levels of MAFG , which drives DNA binding . Positive_regulation MAP2K6 BRAF 7565795 328434 The activation of delta : ER consistently *led* to the rapid and robust activation of both [MEK] and p42/p44 MAP kinases . Positive_regulation MAP2K6 BRAF 7962002 279230 Little or no MEK activator was associated with c-Raf-1 in bovine brain or chromaffin cells , although this protein was expressed , suggesting that might be the major [MEK] *activator* in cells of neural origin . Positive_regulation MAP2K6 BRAF 8668348 365619 We show that , consequently , B-Raf interacts with MEK-1 and MEK-2 with a better affinity than does c-Raf-1 , thus strengthening the notion that is a stronger [MEK] *activator* than c-Raf-l . Positive_regulation MAP2K6 BTRC 14592835 1209500 Western blot analyses revealed that was *required* for phosphorylation of [MEK] and p44MAPK in this setting , and quantitative polymerase chain reaction demonstrated a significant increase in gamma-globin mRNA . Positive_regulation MAP2K6 BTRC 22086674 2605279 Signaling analysis with immunoblots revealed that in human melanocytes or human melanoma cells treated with WSE , there was a marked deficiency in *stimulated* phosphorylation of ERK , MITF and CREB , but not of Raf-1 and [MEK] . Positive_regulation MAP2K6 C5 24043889 2851696 [Gai/c-Raf/MEK/ERK] signaling *induced* by was amplified in macrophages but not in monocytes by LPS . Positive_regulation MAP2K6 CA1 21506110 2418482 In addition , ( 2+ ) signaling inhibitors , such as inositol 1,4,5-trisphosphate receptor antagonist ( 2-APB ) , PKC inhibitor ( GF109203 ) , and CaMKII inhibitor ( KN-62 ) , *blocked* phosphorylation of [MEK] activated by IL-3 and GM-CSF , suggesting the participation of Ca ( 2+ ) -dependent kinases in MEK activation . Positive_regulation MAP2K6 CALM3 11953456 930634 Contribution of Ca2+ *dependent* protein kinase II and [mitogen activated protein kinase kinase] to neural activity induced neurite outgrowth and survival of cerebellar granule cells . Positive_regulation MAP2K6 CALM3 11953456 930641 We explored the contribution of two intracellular pathways , Ca2+ *dependent* protein kinase II and [mitogen activated protein kinase kinase] ( MEK1 ) , to the effects of high [ K+ ] e under serum-free conditions . Positive_regulation MAP2K6 CALM3 12788788 1097212 Thrombin induced ERK dependent caldesmon phosphorylation ( Ser789 ) was inhibited by either KN-93 , a specific kinase II inhibitor , or U0126 , an *inhibitor* of [MEK] activation . Positive_regulation MAP2K6 CASP1 12231068 988468 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Positive_regulation MAP2K6 CASP1 19494289 2091608 ASC mediated AP-1 activation was inhibited by chemical or protein inhibitors for caspase-8 , caspase-8 targeting small interfering RNA , and p38 and JNK inhibitors , but not by a inhibitor , caspase-9 or Fas associated death domain protein ( FADD ) dominant negative mutants , FADD- or RICK targeting small interfering RNAs , or a [MEK] *inhibitor* , indicating that the ASC induced AP-1 activation is mediated by caspase-8 , p38 , and JNK , but does not require caspase-1 , caspase-9 , FADD , RICK , or ERK . Positive_regulation MAP2K6 CASP10 12231068 988469 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Positive_regulation MAP2K6 CASP12 12231068 988479 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Positive_regulation MAP2K6 CASP14 12231068 988470 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Positive_regulation MAP2K6 CASP16 12231068 988480 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Positive_regulation MAP2K6 CASP2 12231068 988471 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Positive_regulation MAP2K6 CASP3 12231068 988472 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Positive_regulation MAP2K6 CASP4 12231068 988473 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Positive_regulation MAP2K6 CASP5 12231068 988474 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Positive_regulation MAP2K6 CASP6 12231068 988475 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Positive_regulation MAP2K6 CASP7 12231068 988476 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Positive_regulation MAP2K6 CASP8 12231068 988477 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Positive_regulation MAP2K6 CASP9 12231068 988478 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Positive_regulation MAP2K6 CAV1 20021823 2175452 Western blotting results showed that overexpression of *reduced* the phosphorylation of EGFR , c-Raf , [Mek] and Erk while did not affect the activity of p38 and SAPK/JNK . Positive_regulation MAP2K6 CCK 7611406 312045 *Activation* of [MAP kinase kinase (MEK)] and Ras by in rat pancreatic acini . Positive_regulation MAP2K6 CCND1 22579115 2609558 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated and Cyclin B1 proteins as well as *activation* of PI3K/Akt and [Raf/MEK/ERK] , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation MAP2K6 CD14 16879219 1593843 Lipopolysaccharide induced decreased protein S expression in liver cells is mediated by [MEK/ERK] signaling and NFkappaB *activation* : involvement of membrane bound and toll-like receptor-4 . Positive_regulation MAP2K6 CD14 16879219 1593867 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by [MEK/ERK] signaling and NFkappaB activation and that membrane bound and TLR-4 are *involved* in this mechanism . Positive_regulation MAP2K6 CD209 23378214 2793799 Treatment of the cells with antibody to *results* in inhibition of the E2 binding as well as the E2-induced [MEK] and ERK activation . Positive_regulation MAP2K6 CD44 20956971 2389481 The results raise the novel idea that the EGFR may activate [Raf-MEK-ERK] signaling in *response* to the binding of HA to . Positive_regulation MAP2K6 CD8A 20595932 2303442 These results suggest that the interaction between on veto CTL and the MHC class I alpha3 domain on the effector cell , *leads* to phosphorylation of [MEK/ERK] in the latter cell , associated with a significant reduction of XIAP levels which , in turn , enables potent triggering of Fas-FasL mediated apoptosis on cognate binding of the veto CTLs . Positive_regulation MAP2K6 CD8B 20595932 2303443 These results suggest that the interaction between on veto CTL and the MHC class I alpha3 domain on the effector cell , *leads* to phosphorylation of [MEK/ERK] in the latter cell , associated with a significant reduction of XIAP levels which , in turn , enables potent triggering of Fas-FasL mediated apoptosis on cognate binding of the veto CTLs . Positive_regulation MAP2K6 CDC37 10022854 590233 In this study , we examined the *role* of and its Hsp90 chaperone partner in [Raf/Mek/MAPK] signaling biochemically . Positive_regulation MAP2K6 CDC42 11304531 826858 Galpha ( q ) stimulated MKK3 in a Rac- and *dependent* manner and [MKK6] in a Rho dependent manner . Positive_regulation MAP2K6 CDC73 10606930 655865 The results showed that TNF alpha , IL-1 alpha and *induced* serine phosphorylation of MKK3 and [MKK6] , and p38 MAP kinase activation in BECs . Positive_regulation MAP2K6 CDH13 12832462 1105624 NF-kappaB1 negatively *regulates* TPL-2 [MEK] kinase activity . Positive_regulation MAP2K6 CDH13 12832462 1105655 Binding to the p105 death domain inhibits TPL-2 [MEK] kinase activity in vitro , and this inhibition is significantly *augmented* by concomitant interaction of the TPL-2 C terminus with . Positive_regulation MAP2K6 CDK5R1 22833568 2670914 The inhibition of activity *results* in enhanced [MEK-ERK] signaling , leading to CRNA . Positive_regulation MAP2K6 CIB1 10951574 723772 Inhibition of [MEK] activation completely abrogated OSM and IL-6 *induced* p27kip1 accumulation , while expression of dominant negative STAT5 decreased the OSM and IL-6 mediated inhibition of DNA-synthesis and partially inhibited accumulation . Positive_regulation MAP2K6 CKS1B 20930946 2357118 Over-expression of *activates* both [MEK/ERK] and JAK/STAT3 signaling pathways and promotes myeloma cell drug-resistance . Positive_regulation MAP2K6 CLU 15857407 1400249 The [mitogen activated protein kinase kinase] and protein kinase C inhibitors PD98059 and H7 inhibited mediated *induction* of reactive nitrogen intermediate secretion from cultured microglia . Positive_regulation MAP2K6 CLU 19218870 2039552 Exogenous *stimulates* Ras dependent [Raf-1/mitogen activated protein kinase kinase] ( MEK ) /ERK activation . Positive_regulation MAP2K6 CNKSR3 19567370 2149704 In parallel , expression *led* to decreased [MEK] phosphorylation . Positive_regulation MAP2K6 CNR1 12657697 1073305 Both effects were attributable to stimulation of and *activation* of [MAP kinase/ERK kinase (MEK)] . Positive_regulation MAP2K6 CNR1 16864584 1613482 A functional MEK-ERK pathway is an important requirement for CB1 mediated Krox-24 induction as blockade of [MEK] signaling by UO126 reduces both basal and mediated *activation* of Krox-24 . Positive_regulation MAP2K6 CRK 11085935 750699 Similarly , *activation* of JNK by Ad-MKK7D and by [Ad-MKK3bE/Ad-MKK6bE] resulted in the increased expression of PGHS-2 . Positive_regulation MAP2K6 CRK 15207247 1261427 In this report , we demonstrate , using two potent and selective inhibitors of [MEK] *activation* by Raf-1 ( PD-098059 ) and ( SB-203580 ) , that both ERK1/2 and p38 pathways play a key role in the production of IL-8 by porins and LPS . Positive_regulation MAP2K6 CSF1 18275061 1924727 While M-CSF mediated MEK/ERK activation promotes osteoclast survival , the signaling pathway by which *activates* [MEK/ERK] is unresolved . Positive_regulation MAP2K6 CSF1 7700643 297517 Inhibition of MAPK activation is associated with lack of ERK-2 tyrosine phosphorylation , and is not due to the suppression of mediated [MEK] *activation* . Positive_regulation MAP2K6 CSF1 7799956 292464 Expression of a dominant negative ras mutant reduced , but did not abolish , *mediated* stimulation of [MEK] and MAPK . Positive_regulation MAP2K6 CSF2 19143758 2026077 TGFbeta inhibits *induced* phosphorylation of ERK and [MEK] in human myeloid leukaemia cell lines via inhibition of phosphatidylinositol 3-kinase (PI3-k) . Positive_regulation MAP2K6 CSF2 19143758 2026091 PD98059 , a selective inhibitor of MEK , blocked *induced* phosphorylation of [MEK] and ERK but not p85 . Positive_regulation MAP2K6 CSF2 21506110 2418473 Requirement for PLC?2 in IL-3 and *stimulated* [MEK/ERK] phosphorylation in murine and human hematopoietic stem/progenitor cells . Positive_regulation MAP2K6 CSF3 16164983 1456414 Additionally , interleukin-3 , which inhibits G-CSF induced differentiation of 32 Dc l3 cells , also inhibited the ability of to *stimulate* prolonged [MEK/ERK] activation . Positive_regulation MAP2K6 CSF3 16903868 1632700 These findings are consistent with the fact that selectively *activates* [MEK/ERK] and PI3K , but not p38 , in neutrophils . Positive_regulation MAP2K6 CSRP1 22142512 2536327 Our results showed that markedly *activated* [c-Raf/MEK/ERK] and JAK1/ERK signaling pathways but not JAK1/STAT3 signaling pathway by using the phosphor-specific antibodies against these pathways , and blockages of c-Raf/MEK/ERK and JAK1/ERK signaling pathways by the specific ERK1/2 inhibitor U0126 and JAK1 inhibitor piceatannol could significantly decrease CRP induced MMP-10 expression . Positive_regulation MAP2K6 CTF1 19439412 2101380 *activated* two signaling pathways : signal transducer and activator of transcription 3 ( STAT3 ) , and [mitogen activated protein kinase kinase] ( MEK ) , a component of the extracellular signal regulated MAPK ( ERK ) pathway . Positive_regulation MAP2K6 CTGF 15855807 1425623 TGF-beta1 induced connective tissue growth factor ( ) expression in human renal proximal tubule epithelial cells *requires* [Ras/MEK/ERK] and Smad signalling . Positive_regulation MAP2K6 CTNNB1 16478791 1528384 The *activation* of Raf1 , [MEK] and ERK kinases by was reduced by co-expression of APC . Positive_regulation MAP2K6 CTR9 10606930 655866 The results showed that TNF alpha , IL-1 alpha and *induced* serine phosphorylation of MKK3 and [MKK6] , and p38 MAP kinase activation in BECs . Positive_regulation MAP2K6 CUL1 14592835 1209501 Western blot analyses revealed that was *required* for phosphorylation of [MEK] and p44MAPK in this setting , and quantitative polymerase chain reaction demonstrated a significant increase in gamma-globin mRNA . Positive_regulation MAP2K6 CUL1 22086674 2605280 Signaling analysis with immunoblots revealed that in human melanocytes or human melanoma cells treated with WSE , there was a marked deficiency in *stimulated* phosphorylation of ERK , MITF and CREB , but not of Raf-1 and [MEK] . Positive_regulation MAP2K6 CXCL1 11062239 809817 We show here that either exogenous addition or continuous expression of in immortalized melanocytes *enhances* NF-kappaB activation , as well as mitogen activated protein (MAP) kinase kinase kinase ( MEKK) 1 , [MAP kinase kinase (MEK) 3/6] , and p38 MAP kinase activation . Positive_regulation MAP2K6 CXCL12 15601627 1356721 strongly induced phosphorylation of Raf-1 on S338 , the target site for the Rac effector Paks , and *enhanced* the IL-3 induced activation of Raf-1 and [MEK] . Positive_regulation MAP2K6 CXCL12 19350687 2064776 Impaired MSC migration correlated with decreased levels of phosphorylated STAT3 and ERK1/2 , suggesting that stimulation *activates* Jak2/STAT3 as well as [MEK/ERK1/2] signaling , which in turn promotes migration of MSCs toward tumor cells . Positive_regulation MAP2K6 CXCL12 19496172 2108264 Stimulation of cells with *increased* the phosphorylation of [MEK] and extracellular signal regulating kinase ( ERK ) . Positive_regulation MAP2K6 CXCL12 21079155 2376746 The *induced* phosphorylation of ERK and [MEK] in ZAP-70 ( + ) CLL cells was blocked by sorafenib , a small molecule inhibitor of RAF . Positive_regulation MAP2K6 CYR61 22253074 2599953 stimulation *increased* the phosphorylation of FAK , [MEK] , and extracellular signal regulated kinase ( ERK ) . Positive_regulation MAP2K6 DLK1 17210639 1702600 We conclude that *activates* [MEK/ERK] signaling , which is required for Pref-1 inhibition of adipogenesis . Positive_regulation MAP2K6 DUSP6 19106095 2031525 Intriguingly , we observed that [Mek] is positively *regulated* by , whereas Erk itself is negatively regulated . Positive_regulation MAP2K6 EDN1 10391918 626841 However , only PMA and *increased* Ras associated [mitogen activated protein kinase kinase] 1-activating activity , and this was decreased by PKC inhibition , pertussis toxin , and CPT-cAMP . Positive_regulation MAP2K6 EDN1 21442473 2417181 Signaling analysis with specific inhibitors and immunoblots revealed that in melanoma cells treated with the extract , there was a marked deficiency in the *stimulated* phosphorylation of Raf-1 , [MEK] , ERK , MITF and CREB . Positive_regulation MAP2K6 EDN1 23636431 2870435 Analysis of EDN1 signaling demonstrated that arenarol significantly suppressed the *induced* phosphorylation of [MEK] , ERK , MITF and CREB but not of Raf-1s . Positive_regulation MAP2K6 EGF 11461094 839036 did not *stimulate* PI-3K/Akt , [MEK/MAPK] , or p38 MAPK activity in SiHa cells but did transiently activate the c-Jun NH2-terminal kinase (JNK) . Positive_regulation MAP2K6 EGF 12376555 996886 Here we have investigated how [MEK] *activation* by influences the response of fully differentiated and growth arrested pig thyroid epithelial cells in primary culture to TGF-beta1 . Positive_regulation MAP2K6 EGF 12391290 1007600 They also inhibited Ras induced Raf-1 activation in human embryonic kidney 293 cells , Raf-1 and [mitogen activated protein kinase kinase] 1 activities in HT1080 fibrosarcoma cells , and induced Raf-1 *activation* in A549 lung carcinoma cells . Positive_regulation MAP2K6 EGF 16134968 1499141 rapidly *increased* the levels of phosphorylated [MEK] ( p-MEK ) in detergent-soluble fractions and phosphorylated ERK ( p-ERK ) in detergent-insoluble fractions . Positive_regulation MAP2K6 EGF 16135787 1450377 In addition , both knockdown and overexpression of IQGAP1 reduced *stimulated* activation of [MEK] and ERK . Positive_regulation MAP2K6 EGF 17183546 1695262 In the present study , we demonstrate that [MEK] *activation* by increased Rac1 activation , dissociation of intercellular contacts , and migration in both control and polyamine depleted cells , while U0126 , a specific inhibitor of MEK1 , prevented disruption of junctions as well as EGF induced Rac1 activation . Positive_regulation MAP2K6 EGF 17563371 1763014 We previously documented that IQGAP1 binds ERK and MAPK kinase ( MEK ) and regulates *stimulated* [MEK] and ERK activity . Positive_regulation MAP2K6 EGF 18197253 1857111 PKA activity leads to the phosphorylation of a constitutive mitochondrial MEK1/2 pool with a lower effect in cytosolic MEKs , while *allows* predominant cytosolic [MEK] activation and nuclear pERK1/2 localization . Positive_regulation MAP2K6 EGF 18381200 1907033 Suppression of protein l-isoaspartyl ( d-aspartyl ) methyltransferase results in hyperactivation of *stimulated* [MEK-ERK] signaling in cultured mammalian cells . Positive_regulation MAP2K6 EGF 19022560 2029226 Furthermore , *activation* of Raf-1 , [MEK] and the ERKs by either or Ras ( G12R ) was inhibited by NM23H2 overexpression . Positive_regulation MAP2K6 EGF 20220516 2237352 TLN-4601 prevented *induced* phosphorylation of Raf-1 , [MEK] , and ERK1/2 . Positive_regulation MAP2K6 EGF 20810616 2341750 We found that nanomolar concentrations of Sorafenib reduced the basal activity of ERK , *inhibited* cAMP dependent activation of B-Raf and [MEK/ERK] signaling , and caused a concentration dependent inhibition of cell proliferation induced by cAMP , , or the combination of the two agonists . Positive_regulation MAP2K6 EGF 22538822 2596039 These studies therefore offer insights into ( i ) allosteric inhibition of KGA by BPTES , revealing the dynamic nature of KGA 's active and inhibitory sites , and ( ii ) cross-talk and regulation of KGA activities by *mediated* [Raf-Mek-Erk] signaling . Positive_regulation MAP2K6 EGF 8529659 336781 Activation of two isoforms of [mitogen activated protein kinase kinase] in *response* to and nerve growth factor . Positive_regulation MAP2K6 EGF 9065732 418325 In the two cell lines , tyrphostin modified the time course of *dependent* [MEK] and MAP kinase activation . Positive_regulation MAP2K6 EGF 9671314 519852 Pretreatment of MDCK and TMK1 cells with 2- ( 2-amino-3-methoxyphenyl ) choromone ( AMPC ) , a specific inhibitor of MEK , selectively inhibited the HGF- , PMA- and *stimulated* activities of [MEK] , 41/43 kDa MAP kinases and p90rsk in a dose dependent manner . Positive_regulation MAP2K6 EGF 9688845 522642 [MEK] *stimulation* by either or epinephrine was not altered with aging . Positive_regulation MAP2K6 EGFR 11098053 786429 By contrast , [MEK] activity *required* activation and , as shown by use of the MEK inhibitor PD98059 and a dominant negative MEK construct , was necessary for Bcl-x ( L ) expression and survival . Positive_regulation MAP2K6 EGFR 11098053 786443 In conclusion , our results demonstrate that *dependent* [MEK] activity contributes to both Bcl-x ( L ) expression and survival of normal keratinocytes . Positive_regulation MAP2K6 EGFR 19190345 2038998 Here , we provide evidence that integration of the HH/GLI and epidermal growth factor receptor (EGFR) pathway synergistically induces oncogenic transformation , which depends on mediated *activation* of the [RAS/RAF/MEK/ERK] but not of the PI3K/AKT pathway . Positive_regulation MAP2K6 EGFR 20956971 2389482 The results raise the novel idea that the may *activate* [Raf-MEK-ERK] signaling in response to the binding of HA to CD44 . Positive_regulation MAP2K6 EGFR 21630605 2437060 The skin toxicity profile of inhibitors , [MEK] en Raf *inhibitors* , mTOR inhibitors , VEGF targeting molecules , multikinase inhibitors , the HER2 monoclonal antibody trastuzumab and the CTLA-4 monoclonal antibodies are discussed . Positive_regulation MAP2K6 EGFR 23821363 2838905 PDKZ1 also appeared to interact with the Src/ER-a/epidermal growth factor receptor (EGFR) complex , but not with IGF-1R and enhanced *stimulated* [MEK/ERK1/2] signaling . Positive_regulation MAP2K6 EGFR 24021351 2856994 The inhibitor also *inhibited* the B [ a ] PDE induced [MEK/ERK] and Akt signaling pathways and subsequently , suppressed COX-2 expression and promoter activity , in addition to suppressing the transactivation of AP-1 and NF-?B . Positive_regulation MAP2K6 EGFR 8396128 230253 In contrast , *mediated* activation of Ras , Raf , [MEK] and MAPK was pertussis toxin-insensitive . Positive_regulation MAP2K6 EGFR 9774681 540045 Our results strongly suggest that a key mechanism by which specific ECMs facilitate retinoid induced mucosecretory differentiation of NHBEs is by restricting the level of dependent [MEK/MAPK] *activation* evoked by autocrine and/or paracrine EGFR ligands . Positive_regulation MAP2K6 EGR1 10501181 648261 Cholinergic stimulation of DNA binding activity *requires* protein kinase C and [mitogen activated protein kinase kinase] activation and is inhibited by sodium valproate in SH-SY5Y cells . Positive_regulation MAP2K6 EGR1 16864584 1613483 A functional MEK-ERK pathway is an important requirement for CB1 mediated Krox-24 induction as blockade of [MEK] signaling by UO126 reduces both basal and CB1 mediated *activation* of . Positive_regulation MAP2K6 EGR1 23468876 2750158 EGR-1 siRNA also reduced *induced* [cRaf/MEK/ERK] phosphorylation by 80 % . Positive_regulation MAP2K6 ELK1 11888673 920064 Raf-1 modification and [MEK] activation also occurred after TRO treatment , and dependent trans-reporter gene expression was concomitantly *induced* . Positive_regulation MAP2K6 EPHB2 10996792 733918 As in proliferating cells , activation during G0 *required* the MAPkinase kinase [MEK] and was partially dependent on cell adhesion . Positive_regulation MAP2K6 EPHB2 11304535 819985 However , cyclin E expression is ineffectual in rescuing these effects when ERK activation is blocked by treatment with PD98059 , a selective inhibitor of [MEK] *activation* of . Positive_regulation MAP2K6 EPHB2 12675684 1076709 In contrast , the *activation* of by constitutively active forms of [MAP kinase kinase (MEK)] was not inhibited , suggesting that the actions of SptP were mediated by Raf-1 . Positive_regulation MAP2K6 EPHB2 15304546 1322457 Furthermore , *activation* of by the coexpression of constitutively active [MAPKK/MEK] predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAP2K6 EPHB2 15843535 1398480 As in the classical pathway , BCR induced activation in the new , PI3K independent pathway *required* [MEK] and was reflected in c-Raf . Positive_regulation MAP2K6 EPHB2 15855657 1439597 Activation of ERK was attenuated by drugs that disassemble the actin cytoskeleton ( cytochalasin D , latrunculin B ) , and these compounds interfered with the *activation* of by [mitogen activated protein kinase kinase] ( MEK ) . Positive_regulation MAP2K6 EPHB2 17337598 1765829 A pharmacological inhibitor of MEK activity inhibits LPA stimulated WT Hic-5 cell migration and ERK phosphorylation , suggesting Hic-5 enhances migration via [MEK] *activation* of . Positive_regulation MAP2K6 EPHB2 18194435 1895324 Although [mitogen activated protein kinase kinase] ( MEK ) and extracellular signal regulated protein kinase ( ERK ) are activated by GW5074 , pharmacological inhibition of signaling by U0126 or PD98059 does not *reduce* neuroprotection suggesting that B-Raf signals through a non-canonical signaling pathway . Positive_regulation MAP2K6 EPHB2 22328534 2642863 PD98059 , [MEK] *inhibitor* , or U0126 , inhibitor , reduced SNU668 cell migration accompanying an increase in p-GSK-3a , ß-catenin and E-cadherin . Positive_regulation MAP2K6 EPHB2 22506069 2583981 Activations of [MEK] , ERK , and NF-?B pathways after CCL5 treatment were demonstrated , and CCL5 induced expression of integrin and migration activity was *inhibited* by the specific inhibitor and mutant of MEK , , and NF-?B cascades . Positive_regulation MAP2K6 EPHB2 22740332 2715450 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Positive_regulation MAP2K6 EPHB2 22785235 2691841 TRH induced CRE promoter was inhibited by mitogen activated protein kinase ( MEK ) inhibitor and was *increased* by overexpression of [MEK kinase (MEKK)] . Positive_regulation MAP2K6 EPHB2 22892241 2666345 However , unlike ( V600E ) Braf , pathway activation was mediated by both Craf and Braf , and ATP-competitive RAF inhibitors *induced* paradoxical [Mek/Erk] pathway activation . Positive_regulation MAP2K6 EPHB2 7838428 286302 The protein expression profiles were almost equivalent , but the MEK expression was slightly advanced , suggesting that the observed up-regulation of [MEK] was not *due* to that of . Positive_regulation MAP2K6 EPHB2 8226933 235477 Phosphorylation of [MEK] is also *stimulated* by . Positive_regulation MAP2K6 EPOR 15743794 1378990 in melanoma cells was functional , because exogenous Epo increased melanoma resistance to hypoxic stress , pretreatment of melanoma cells with Epo significantly increased resistance to dacarbazine treatment , and Epo *increased* the phosphorylation of EpoR , RAF , and [MEK] . Positive_regulation MAP2K6 EPX 15743794 1378991 EpoR in melanoma cells was functional , because exogenous Epo increased melanoma resistance to hypoxic stress , pretreatment of melanoma cells with Epo significantly increased resistance to dacarbazine treatment , and *increased* the phosphorylation of EpoR , RAF , and [MEK] . Positive_regulation MAP2K6 EREG 23829318 2815932 Human recombinant protein promoted cell proliferation and *enhanced* Erk1/2 , [MEK] and JNK phosphorylation in SCAPs . Positive_regulation MAP2K6 FADD 19758790 2183433 Marked concomitant increases in the content of ( 48 % ) and the *activation* of [MEK-ERK] ( 46-79 % ) were quantified during the short-term expression of morphine sensitization ( SW 3 , in the absence of morphine challenge ) . Positive_regulation MAP2K6 FCGR3B 19342628 2056783 Also , ERK , but not [MEK] , was constitutively present in the nucleus , and cross linking did not *increase* the levels of nuclear ERK or MEK . Positive_regulation MAP2K6 FGF1 15231676 1269262 Despite a short lived activation of Ras and Raf-1 by all three of the growth factors , both and HRGbeta1 , unlike EGF , *induced* a prolonged activation of [MEK] and ERK1/2 in these cells . Positive_regulation MAP2K6 FGF1 17548887 1778525 SU5402 , an inhibitor of FGF receptor , inhibited *induced* phosphorylation of [MEK] , ERK , and Akt , as well as all the apoE-HDL biogenesis related events in rat astrocytes . Positive_regulation MAP2K6 FGF1 18216067 1903426 Phosphorylation of Akt , ERK and [MEK] were *induced* by in W/W cells but not in W/M cells . Positive_regulation MAP2K6 FGF2 11564685 863256 ACTH and each increased Mek phosphorylation and *stimulated* [Mek] activity in both cell lines and also activated the Erks at concentrations that paralleled their effects on Mek . Positive_regulation MAP2K6 FGF2 15123617 1266640 Conversely , *dependent* [MEK] phosphorylation was not affected , suggesting a direct effect on ERK1/2 . Positive_regulation MAP2K6 FGF2 15217807 1281797 Our data suggest that *induced* [MEK/extracellular] signal regulated kinase signaling plays an antagonistic role in TGFbeta1 induced SMC gene expression through suppression of the SRF function . Positive_regulation MAP2K6 FGF2 15659806 1350183 Since *dependent* [MEK] phosphorylation was not affected by SST , we propose a direct effect of SST activated PTPeta on ERK1/2 phosphorylation . Positive_regulation MAP2K6 FGF2 16234329 1470495 *mediated* activation of both [MEK] and Raf-1 but not Ras or FRS2 was abolished by CNP demonstrating that CNP blocks the Erk pathway at the level of Raf-1 . Positive_regulation MAP2K6 FGF2 17145761 1686993 Bis I inhibited *induced* activation of [MEK] , Raf-1 , and Ras members of Erk signaling module but not the FGF2 induced tyrosine phosphorylation of Frs2 or the kinase activity of FGFR3 , demonstrating that it targets the Erk cascade immediately upstream of Ras . Positive_regulation MAP2K6 FGF2 21351506 2360948 The effect of P7 on *induced* activation of [MEK] and Erk1/2 in MAPK pathway was detected by Western blotting . Positive_regulation MAP2K6 FGF2 21351506 2360957 The results of MAP kinase activation assay indicated that P7 decreased *induced* [MEK] and Erk1/2 phosphorylation in a dose dependent manner . Positive_regulation MAP2K6 FNTA 23546290 2763083 Second , inhibitor I , a Ras inhibitor , and U0126 , a [MEK] *inhibitor* , induced an inhibition of the cell proliferation in C6 cells , while the cell proliferation was inhibited by nobiletin as well . Positive_regulation MAP2K6 FNTB 23546290 2763084 Second , inhibitor I , a Ras inhibitor , and U0126 , a [MEK] *inhibitor* , induced an inhibition of the cell proliferation in C6 cells , while the cell proliferation was inhibited by nobiletin as well . Positive_regulation MAP2K6 FOS 15005710 1217472 Cytoplasmic induced by the YXXQ derived STAT3 signal *requires* the co-operative [MEK/ERK] signal for its nuclear translocation . Positive_regulation MAP2K6 GABRA1 10648867 662309 These results thus suggest that both BDNF dependent and -independent expressions of subunits *require* the activation of [MEK] and the mitogen activated protein kinase (MAPK) pathway . Positive_regulation MAP2K6 GABRB2 10648867 662310 These results thus suggest that both BDNF dependent and -independent expressions of subunits *require* the activation of [MEK] and the mitogen activated protein kinase (MAPK) pathway . Positive_regulation MAP2K6 GABRG2 10648867 662311 These results thus suggest that both BDNF dependent and -independent expressions of subunits *require* the activation of [MEK] and the mitogen activated protein kinase (MAPK) pathway . Positive_regulation MAP2K6 GDF15 12907645 1119276 We also found that the stimulation of human gastric cell lines with recombinant strongly *induced* activation of [mitogen activated protein kinase kinase-1/2] and extracellular signal regulated kinase-1/2 . Positive_regulation MAP2K6 GDF15 18413810 1894231 Forced expression of constitutively active [MKK6] , an upstream kinase for p38 , *induced* an increase in promoter activity , whereas p38 kinase inhibitor blocked MKK6 induced increase in NAG-1 promoter activity . Positive_regulation MAP2K6 GDNF 19399830 2082267 Stimulation of cells with *increased* the phosphorylation of [MEK] and extracellular signal regulating kinase ( ERK ) . Positive_regulation MAP2K6 GDNF 20615395 2309895 Treatment with *induced* [MEK/ERK] and JNK/c-Jun activation and increased AP-1 DNA binding activity in a time dependent manner . Positive_regulation MAP2K6 GDNF 23262364 2763880 stimulation *activates* intracellular PI3K/Akt and [MEK/Erk] signaling cascades as detected by Western blot analysis of cultures prepared from rats at postnatal days 5 ( P5 , before the onset of hearing ) and 20 ( P20 , after the onset of hearing ) . Positive_regulation MAP2K6 GDNF 23468876 2750159 EGR-1 siRNA also reduced *induced* [cRaf/MEK/ERK] phosphorylation by 80 % . Positive_regulation MAP2K6 GPI 23394468 2920604 Finally , we proposed a possible hypothesis for the mechanism of NLK in the growth and survival of SC-induced neurons based on Western blotting results , which is that secreted by SCs *activates* the [Ras/Raf/MEK/Erk] , Jak/Stat , and PI3K/Akt pathways , but not the NF-?B pathway , in neurons resulting in their growth and survival . Positive_regulation MAP2K6 GRAP2 11010976 752631 We also found that the preferential *activation* of by [MKK6] correlated with more efficient binding of MKK6 to p38alpha than to p38gamma . Positive_regulation MAP2K6 GRAP2 11971971 933745 Constitutive *activation* of by active MKK3 or [MKK6] induces senescence . Positive_regulation MAP2K6 GRAP2 12181443 977740 Among 12 cell lines that we tested , 11 respond to LPA and S1P and all of the responsive cell lines *require* but only nine of them require [MEK] . Positive_regulation MAP2K6 GRAP2 12509443 1038610 Finally , the identification of the *dependent* upstream activator [MAP kinase kinase 6] as a member of this group identifies a positive feedback loop regulating macrophage signaling via p38 MAP kinase dependent transcript stabilization . Positive_regulation MAP2K6 GRAP2 14708598 1181098 *Activation* of alone by adenovirally delivered constitutively active MAPK kinase 3b (MKK3b) and [MKK6b] also enhanced MMP-19 production , and the most potent induction of MMP-19 expression was noted when ERK1/2 was activated in combination with p38 . Positive_regulation MAP2K6 GRAP2 15104236 1240250 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a mitogen activated protein kinase (MAPK) inhibitor , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( [MEK] ) *inhibitor* , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAP2K6 GRAP2 15365248 1294515 Treatment of keratinocytes with PD98059 , [MEK] *inhibitor* , and SB20358 , MAPK inhibitor , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAP2K6 GRAP2 16157033 1455707 SB203580 , a inhibitor , and U0126 , a [MEK] *inhibitor* , both completely blocked ADM mediated responses in MsC . Positive_regulation MAP2K6 GRAP2 16352664 1504374 The phosphorylation of induced by NP60 *requires* upstream activity of p38alpha MAP kinase , [MAP kinase kinase 6 (MKK6)] or MKK4 . Positive_regulation MAP2K6 GRAP2 18413810 1894232 Forced expression of constitutively active [MKK6] , an upstream kinase for p38 , *induced* an increase in NAG-1 promoter activity , whereas kinase inhibitor blocked MKK6 induced increase in NAG-1 promoter activity . Positive_regulation MAP2K6 GRAP2 19293637 2056031 To identify the downstream pathways regulated by ROS , we treated cells with PD 98059 , an [MEK] *inhibitor* , and SB 203580 , a inhibitor , after treatment with H ( 2 ) O ( 2 ) , and showed negative control between ERK and p38 kinase activities for uPA regulation . Positive_regulation MAP2K6 GRAP2 20398804 2293962 Adding [MEK] inhibitor in the *presence* of inhibitor further reduced TNFalpha release suggesting that the ERK pathway plays a role in GM-CSF induced reduction of the p38 inhibitor potency . Positive_regulation MAP2K6 GRAP2 21288261 2419834 Using two potent and selective inhibitors of [MEK] *activation* by Raf-1 ( PD-098059 ) and ( SB-203580 ) , it was also demonstrated that both ERK1/2 and p38 pathways play key roles in the production of IL-6 as well as in ICAM-1 , VCAM-1 and E-selectin expression by Hib porin . Positive_regulation MAP2K6 GRAP2 21769916 2494811 In TGW cells , PD98059 , a [MEK] *inhibitor* , but not SB203580 ( a MAPK inhibitor ) and LY294002 ( a PI3K inhibitor ) inhibited GDNF induced GAP43 expression , suggesting the MEK/ERK pathway has a major role in GDNF induced GAP43 transcription . Positive_regulation MAP2K6 GRAP2 22413812 2600531 The H2O2 augmented IFN? induced IL-32 mRNA expression was suppressed by a JNK inhibitor , but not by [MEK] *inhibitor* , inhibitor , and JAK inhibitor I. Significant binding of c-Jun and CREB to the IL-32 promoter was observed in the IFN? + H2O2 stimulated HBE cells . Positive_regulation MAP2K6 GRAP2 8663524 368610 A comparison of events associated with the activation of p38beta and p38 revealed differences , most notably in the preferred *activation* of by [MAP kinase kinase 6 (MKK6)] , whereas p38 was activated nearly equally by MKK3 , MKK4 , and MKK6 . Positive_regulation MAP2K6 GRB2 11230180 789127 PTEN *inhibits* insulin stimulated [MEK/MAPK] activation and cell growth by blocking IRS-1 phosphorylation and complex formation in a breast cancer model . Positive_regulation MAP2K6 GRIP1 20346402 2281730 *increased* the E ( 2 ) -dependent ERE activation in the presence of ERalpha and constitutive-active [MKK6] . Positive_regulation MAP2K6 GRM1 21098662 2360522 The remaining LTD was reduced by anisomycin , an inhibitor of protein synthesis , by U0126 , an inhibitor of MEK1/2 kinases , and by rapamycin , an inhibitor of mammalian target of rapamycin (mTOR) , suggesting mediation by the same mechanisms as in WT. *dependent* activation ( phosphorylation ) of [MEK] and extracellular signal regulated kinase ( ERK1/2 ) was altered in Cav1 ( -/- ) mice ; Positive_regulation MAP2K6 GRM3 21946352 2497674 Biochemical analysis of GRM3 alterations revealed that mutant selectively *regulated* the phosphorylation of [MEK] , leading to increased anchorage independent growth and migration . Positive_regulation MAP2K6 GRM5 21098662 2360523 The remaining LTD was reduced by anisomycin , an inhibitor of protein synthesis , by U0126 , an inhibitor of MEK1/2 kinases , and by rapamycin , an inhibitor of mammalian target of rapamycin (mTOR) , suggesting mediation by the same mechanisms as in WT. *dependent* activation ( phosphorylation ) of [MEK] and extracellular signal regulated kinase ( ERK1/2 ) was altered in Cav1 ( -/- ) mice ; Positive_regulation MAP2K6 HGF 11585709 866137 also *activated* [MEK] , p44/42 MAPK , and p90RSK . Positive_regulation MAP2K6 HGF 12379223 997111 Stimulation with *led* to activation of Met as well as to activation of PI3-K , PKB/Akt , [MEK] , and the MAP kinases Erk1 and -2 . Positive_regulation MAP2K6 HIST1H1C 21712392 2483831 Also , 12- ( S ) <-HETE/12-HETER> interactions *lead* to activation of ERK1/2 , [MEK] , and NF?B . Positive_regulation MAP2K6 HRAS 12391290 1007601 They also inhibited *induced* Raf-1 activation in human embryonic kidney 293 cells , Raf-1 and [mitogen activated protein kinase kinase] 1 activities in HT1080 fibrosarcoma cells , and epidermal growth factor induced Raf-1 activation in A549 lung carcinoma cells . Positive_regulation MAP2K6 HRAS 15308774 1284969 Azido farnesylated proteins maintain the properties of protein farnesylation , including promoting membrane association , dependent [mitogen activated protein kinase kinase] *activation* , and inhibition of lovastatin induced apoptosis . Positive_regulation MAP2K6 HRAS 15677464 1388371 In contrast , [Raf-MEK-ERK] and phosphatidylinositol 3-kinase-Akt pathways , which are fundamental to proliferation and differentiation , are *activated* by both and N-Ras . Positive_regulation MAP2K6 HRAS 16041367 1437740 Prohibitin is required for *induced* [Raf-MEK-ERK] activation and epithelial cell migration . Positive_regulation MAP2K6 HRAS 18275061 1924775 As further support for Ras mediated signaling , constitutively active ( ca ) *promoted* [MEK/ERK] activation and osteoclast survival , which was blocked by inhibition of PI3K or Raf . Positive_regulation MAP2K6 HRAS 19022560 2029227 Furthermore , *activation* of Raf-1 , [MEK] and the ERKs by either EGF or ( G12R ) was inhibited by NM23H2 overexpression . Positive_regulation MAP2K6 HRAS 19218870 2039553 Exogenous clusterin stimulates *dependent* [Raf-1/mitogen activated protein kinase kinase] ( MEK ) /ERK activation . Positive_regulation MAP2K6 HRAS 20676060 2311799 There , *initiates* activation of [MEK] , which in turn inhibits LIM-kinase 1 activity , thereby allowing dephosphorylation of the F-actin remodelling protein cofilin . Positive_regulation MAP2K6 HRAS 21536655 2440186 Thus , the interaction of LOX-PP with Hsp70 and c-Raf inhibits a critical intermediate in *induced* [MEK] signaling and plays an important role in the function of this tumor suppressor . Positive_regulation MAP2K6 HRAS 22847612 2803131 The Bach1-deficient cells showed diminished phosphorylation of [MEK] and ERK1/2 in *response* to ( V12 ) , which was consistent with the alterations in the gene expression profile , including phosphatase genes . Positive_regulation MAP2K6 HRAS 22975374 2673994 Without EGFR activity , active levels are not *sufficient* to induce robust [MEK/ERK] activity , a requirement for epithelial transformation . Positive_regulation MAP2K6 HRAS 23546290 2763085 Second , farnesyltransferase inhibitor I , a inhibitor , and U0126 , a [MEK] *inhibitor* , induced an inhibition of the cell proliferation in C6 cells , while the cell proliferation was inhibited by nobiletin as well . Positive_regulation MAP2K6 HRAS 24327733 2880387 Unexpectedly , we found that in PIK3CA mutant and HER2 amplified breast cancers sensitive to PI3K inhibitors , PI3K inhibition led to a rapid suppression of Rac1/p21 activated kinase (PAK)/protein kinase C-RAF ( C-RAF ) / protein kinase [MEK] ( MEK ) /ERK signaling that did not *involve* . Positive_regulation MAP2K6 HRAS 7611406 312090 In conclusion , the activation of MAP kinase by CCK can be explained by activation of [MEK] and may *involve* the activation of by a protein kinase C-dependent mechanism . Positive_regulation MAP2K6 HRAS 7673108 322673 We report here that the cascade of serine kinases activated directly by *results* in a [mitogen activated protein kinase kinase] ( MEK ) -dependent phosphorylation of SOS and subsequent disassociation of the Grb2-SOS complex , thereby interrupting the ability of SOS to catalyze nucleotide exchange on Ras . Positive_regulation MAP2K6 HRAS 7852306 294417 We have previously identified a protein factor , named REKS ( Ras dependent Extracellular signal regulated kinase/Mitogen activated protein kinase kinase ( MEK ) Stimulator ) , which is necessary for dependent [MEK] *activation* . Positive_regulation MAP2K6 HRAS 8014190 262405 The Raf dependent pathway involves Ras activation , while the Raf independent activation of [MEK] and MAPK does not *involve* . Positive_regulation MAP2K6 HRAS 8182145 256509 One of these pathways involves the activation of , leading to the activation of Raf-1 , and the subsequent *activation* of [MEK] ( MAPK or ERK kinase ) . Positive_regulation MAP2K6 HRAS 8590798 342488 *Activation* of MAPK and [MEK] by Gi2 was blocked by expression of a dominant negative mutant of . Positive_regulation MAP2K6 HRAS 9484798 488170 ERK-2 is activated via a kinase cascade initiated by activation of the G protein followed by phosphorylation and *activation* of Raf-1 and [mitogen activated protein kinase kinase-1] ( MEK-1 ) . Positive_regulation MAP2K6 HRG 9652748 515930 Moreover , these data are compatible with induced *activation* of [MEK] being critical for a mid-G1 transition point and implicate c-myc and cyclin D1 as key targets of the MAP kinase pathway involved in this response . Positive_regulation MAP2K6 HSP90AA1 18281615 1911686 Analysis of the expression of and *activation* of the [MEK/ERK] downstream signaling of B-Raf was performed by Western blot . Positive_regulation MAP2K6 HSP90AA1 18281615 1911694 The inhibition of downregulated B-Raf , decreased cell proliferation , and *reduced* activation of [MEK/ERK] in uveal melanoma cell lines expressing WT B-Raf . Positive_regulation MAP2K6 HTR2A 9435197 482476 Taken together , these studies indicate that stimulation of a vascular <5-HT2A> receptor *activates* Ca++ channels and PLC as well as [MEK] to cause rat aortic contraction and that MEK activation is at least partially independent of the two pathways classically associated with 5-HT2A receptors . Positive_regulation MAP2K6 HTR2A 9928253 559933 *Activation* of a tyrosine [kinase/MEK] via the <5-HT2A> receptor was partially independent of two major signaling pathways typically associated with the 5-HT2A receptor -- activation of L-type voltage gated calcium channels and phospholipase C. Western analyses using antibodies directed against tyrosyl-phosphorylated- , activated Erk MAPK , and MEK proteins from cultured aortic smooth muscle cells demonstrated that 5-HT activated MEK and the Erk MAPKs in a time- , concentration- , receptor- and tyrosine kinase dependent manner . Positive_regulation MAP2K6 ID1 14742319 1250771 *induced* [Raf/MEK] pathway activation is essential for its protective role against taxol induced apoptosis in nasopharyngeal carcinoma cells . Positive_regulation MAP2K6 IFI27 10951574 723773 Inhibition of [MEK] activation completely abrogated OSM and IL-6 *induced* p27kip1 accumulation , while expression of dominant negative STAT5 decreased the OSM and IL-6 mediated inhibition of DNA-synthesis and partially inhibited accumulation . Positive_regulation MAP2K6 IFNG 17363736 1760144 *induced* STAT1 activation , via [MEK/ERK] and MyD88/TRAF6 , and inhibition of STAT1 reduced B7-H1 expression . Positive_regulation MAP2K6 IGF1 10872812 707134 While the IGF-I induced activation of PKB/Akt was inhibited by PI3-K inhibitor LY294002 but not by MEK inhibitor PD98059 , the *activation* of both [MEK] and ERK by was inhibited by both . Positive_regulation MAP2K6 IGF1 12930919 1164070 These effects are mediated through both [MEK] and PI 3-kinase pathways but not through the *induction* of TNF-alpha production by the DC . Positive_regulation MAP2K6 IGF1 17210752 1681630 *stimulated* [MEK] and Akt phosphorylation were augmented byoverexpression of constitutively active FOXO1 . Positive_regulation MAP2K6 IGF2 22514330 2584311 This process depends on *mediated* [MEK/ERK] activation . Positive_regulation MAP2K6 IGF2R 22514330 2584312 This process depends on mediated [MEK/ERK] *activation* . Positive_regulation MAP2K6 IKBKB 11149911 780462 TNF-alpha mediated *activation* of [MEK/ERK] and EGR-1 can be blocked by adenoviral expression of a dominant negative mutant of , whereas the VEGF signaling pathway is unaffected . Positive_regulation MAP2K6 IL10 9010681 405225 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL11 9010681 405226 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL12A 10903740 713074 In this report we demonstrate that *activates* [mitogen activated protein kinase kinase] 3/6 ( MKK ) and p38 mitogen activated protein kinase (MAPK) , but not p44/42 ( ERK ) or stress activated protein kinase/c-Jun N-terminal kinase MAPK . Positive_regulation MAP2K6 IL12B 10903740 713075 In this report we demonstrate that *activates* [mitogen activated protein kinase kinase] 3/6 ( MKK ) and p38 mitogen activated protein kinase (MAPK) , but not p44/42 ( ERK ) or stress activated protein kinase/c-Jun N-terminal kinase MAPK . Positive_regulation MAP2K6 IL13 9010681 405227 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL15 9010681 405228 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL16 9010681 405229 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL17A 10555036 565696 Within minutes , *induced* the phosphorylation of [mitogen activated protein kinase kinase-1/2] ( MEK-1/2 ) , -3/6 ( MKK-3/6 ) , p44/42 , p38 , and inhibitor of nuclear factor kappaB ( I kappaB)-alpha , as well as the activation of mitogen activated protein kinase activated protein kinase-1 and -2 ( MAPKAPK-1 and -2 ) . Positive_regulation MAP2K6 IL18 9010681 405230 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL19 9010681 405231 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL1A 10606930 655870 The results showed that TNF alpha , and PAF *induced* serine phosphorylation of MKK3 and [MKK6] , and p38 MAP kinase activation in BECs . Positive_regulation MAP2K6 IL1A 11546664 856633 SB-203580 treatment enhanced *induced* [MEK] , p42/44(mapk) , and cPLA(2)alpha phosphorylation but reduced thrombin stimulated MEK and p42/44(mapk) activation . Positive_regulation MAP2K6 IL1A 17907188 1812711 A rabbit IL-1alpha induced arthritis model was used to assess the effects of the inhibitor on *induced* [MEK] activity , stromelysin production , and cartilage degradation . Positive_regulation MAP2K6 IL1A 21320357 2393854 The effects of and TNF-a on EPCR shedding in DU-145 cells are *mediated* by [MEK/ERK] 1/2 , JNK , and p38 MAPK signalling cascades . Positive_regulation MAP2K6 IL1A 23891856 2849727 alone *stimulated* cRaf ( Ser338 ) , [MEK] ( Ser221 ) and Erk1/2 ( Thr202/Tyr204 ) phosphorylation . Positive_regulation MAP2K6 IL1B 10593906 572875 In previous studies we demonstrated that can *activate* MKK4/SEK1 , MKK3 , and [MKK6] in renal mesangial cells ; Positive_regulation MAP2K6 IL1B 11179516 784777 We found that *induced* ERK phosphorylation , PD153035 and [MEK] inhibitor PD98059 blocked IL-1 beta induced ERK activity . Positive_regulation MAP2K6 IL1B 16043966 1459735 Western blot analysis demonstrated that *increased* the activation of phosphorylated [MEK] and p38 MAPK in GH3 cells . Positive_regulation MAP2K6 IL1B 9786861 540953 Furthermore , our experiments confirm that *activates* MAP kinase kinase-4 (MKK4)/SEK1 , MKK3 , and [MKK6] in renal mesangial cells . Positive_regulation MAP2K6 IL2 12681450 1077457 This report shows that the PI3K inhibitors LY294002 and wortmannin block *activation* of [MEK] and ERK by in primary human T cells . Positive_regulation MAP2K6 IL2 20461527 2301024 The pharmacological inhibition of *induced* [MEK/ERK] or JAK/STAT cascades suppressed the IL-2 induced proliferation and reduced the functional and protein expressions of Na , K-ATPase . Positive_regulation MAP2K6 IL2 9010681 405232 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL20 9010681 405233 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL21 9010681 405234 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL22 24517997 2938269 *increased* MAP3K8 phosphorylation through IL-22R1 , followed by the induction of [MEK-ERK] , JNK-c-Jun , and STAT3 signaling pathways . Positive_regulation MAP2K6 IL22 24517997 2938295 In addition , Pin1 was identified as a key positive regulator for the phosphorylation dependent [MEK] , c-Jun and STAT3 activity *induced* by . Positive_regulation MAP2K6 IL22 9010681 405217 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL24 9010681 405215 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL25 9010681 405216 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL26 9010681 405221 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL27 9010681 405222 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL3 11335710 827497 Expression of Deltap85 and incubation with LY294002 both inhibited induced *activation* of [Mek] , Erk1 , and Erk2 . Positive_regulation MAP2K6 IL3 15601627 1356722 SDF-1 strongly induced phosphorylation of Raf-1 on S338 , the target site for the Rac effector Paks , and enhanced the *induced* activation of Raf-1 and [MEK] . Positive_regulation MAP2K6 IL3 15982852 1498014 The antioxidant N-acetyl-L-cysteine (NAC) inhibited *induced* tyrosine phosphorylation of Jak2 , IL-3 receptor betac subunit ( IL-3Rbetac ) , and STAT5 as well as activation-specific phosphorylation of Akt , [MEK] , and ERK , while treatment of cells with H2O2 activated these signaling events . Positive_regulation MAP2K6 IL3 16164983 1456415 Additionally , , which inhibits G-CSF induced differentiation of 32 Dc l3 cells , also *inhibited* the ability of G-CSF to stimulate prolonged [MEK/ERK] activation . Positive_regulation MAP2K6 IL3 9010681 405235 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL31 9010681 405223 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL32 9010681 405220 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL33 9010681 405219 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL34 9010681 405224 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL37 9010681 405218 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL4 11305324 803788 While alone does not *induce* activation of [MEK] , a MEK1 inhibitor suppressed the IL-4 induced proliferative response of LPS activated B cell blasts . Positive_regulation MAP2K6 IL4 16210650 1464496 *regulates* [MEK] expression required for lysophosphatidic acid mediated chemokine generation by human mast cells . Positive_regulation MAP2K6 IL4 9010681 405236 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL5 9010681 405237 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL6 16899572 1601220 Western blot analysis demonstrated that indeed *increased* the activation of phosphorylated [MEK] and p38 MAPK in GH3 cells . Positive_regulation MAP2K6 IL6 9010681 405238 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL7 16019476 1432081 *induces* the activation of Jak/STAT , [MEK/Erk] and PI3K/Akt signaling pathways in T-ALL cells . Positive_regulation MAP2K6 IL7 9010681 405239 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL8 9010681 405240 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 IL8 9843397 553044 Our results demonstrate the following in CHO cells stably expressing either IL-8 R1 or R2 receptors : ( a ) *activates* ERK and ERK kinases ( [MEK] ) through R1 . Positive_regulation MAP2K6 IL8 9843397 553052 Both and GROalpha *activate* ERK and [MEK] through R2 , whereas MIP-1alpha , a beta chemokine , does not activate these kinases through either of these receptors . Positive_regulation MAP2K6 IL9 9010681 405241 induced signalling : biphasic *activation* of [mitogen activated protein kinase kinase] and mitogen activated protein kinases in HeLa cells . Positive_regulation MAP2K6 INS 10516133 652262 and 3 ) induced *activation* of [MEK] , the upstream activator of ERK , is dependent on PI 3-kinase , whereas contraction utilizes a different mechanism . Positive_regulation MAP2K6 INS 10801816 714477 Here we report that stimulation of HIRcB fibroblasts *leads* to accumulation of Ras , Raf-1 , phosphorylated [MEK] , phosphorylated MAPK , and PA on endosomal membranes . Positive_regulation MAP2K6 INS 11230180 789128 PTEN inhibits stimulated [MEK/MAPK] *activation* and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model . Positive_regulation MAP2K6 INS 11466321 851011 Cholesterol depletion also blocked *dependent* phosphorylation of [MEK] and mitogen activated protein kinase (MAPK) but had no effects on the translocation and activation of Raf-1 . Positive_regulation MAP2K6 INS 14687662 1190237 DPI increased the insulin stimulated phosphorylation of p42/p44 MAP kinase with no change in basal , and increased *stimulated* [MAP kinase kinase (MEK)] activity by a similar degree . Positive_regulation MAP2K6 INS 17659595 1805166 Differential , age dependent [MEK-ERK] and PI3K-Akt *activation* by acting as a survival factor during embryonic retinal development . Positive_regulation MAP2K6 INS 18952605 2001066 Overexpression of the mutant KSR1 in HIRcB cells inhibited *dependent* [MEK] and ERK phosphorylation . Positive_regulation MAP2K6 INS 19808894 2187075 Pharmacological inhibition or silencing of Tpl2 prevented [MEK/ERK1/2] *activation* by these cytokines but not by , demonstrating its involvement in ERK1/2 activation specifically in response to inflammatory stimuli . Positive_regulation MAP2K6 INS 22811470 2670578 Furthermore , increased ß-catenin phosphorylation , its nuclear translocation , and *enhanced* cAMP response element binding protein ( CREB ) phosphorylation in a phosphatidylinositol 3-kinase and/or [mitogen activated protein kinase kinase/extracellular] signal regulated kinase-sensitive manner . Positive_regulation MAP2K6 INS 7706312 297741 The first [MEK] activator has an apparent M ( r ) of 40,000-50,000 , was immunologically distinct from A-Raf , B-Raf , c-Raf-1 , c-MEKK , c-Mos , MEK1 , and MEK2 , and was rapidly *activated* by serum , platelet derived growth factor ( PDGF ) , , thrombin , and phorbol ester . Positive_regulation MAP2K6 INS 8641187 362814 Reduced phosphorylation of [mitogen activated protein kinase kinase] in *response* to in cells with truncated C-terminal domain of insulin receptor . Positive_regulation MAP2K6 INS 9843380 553038 *induced* [MKK3/MKK6] phosphorylation and activation of p38 MAP kinase whose activity was inhibited with SB203580 . Positive_regulation MAP2K6 INSIG1 15731359 1403025 We report that : 1 ) insulin induced transcription of ATF-3 , Pip92 , and *required* [MEK-ERK] activation ; Positive_regulation MAP2K6 IQGAP1 16135787 1450378 In addition , both knockdown and overexpression of *reduced* EGF stimulated activation of [MEK] and ERK . Positive_regulation MAP2K6 IQGAP1 17563371 1763015 We previously documented that binds ERK and MAPK kinase ( MEK ) and *regulates* EGF stimulated [MEK] and ERK activity . Positive_regulation MAP2K6 IRS1 11230180 789129 PTEN *inhibits* insulin stimulated [MEK/MAPK] activation and cell growth by blocking IRS-1 phosphorylation and complex formation in a breast cancer model . Positive_regulation MAP2K6 JAK2 16061232 1442085 Inhibition of TK or activities *blocked* magnolol induced phosphorylation of [MEK] and ERK , again supporting the upstream role of JAK2 . Positive_regulation MAP2K6 JAK2 17169599 1688012 The OSM stimulated expression of SDF-1 in hATSCs was completely abrogated by pretreatment of the cells with U0126 , an [MEK-specific] *inhibitor* , but not with AG490 , a inhibitor , or WHI-P131 , a JAK3 inhibitor , suggesting that ERK , but not JAK2 and JAK3 , is involved in the OSM induced expression of SDF-1 . Positive_regulation MAP2K6 JAK2 18582595 1959325 Inhibition of *prevented* the adenosine induced steroidogenesis and phosphorylation of [mitogen activated protein kinase kinase] 1/2 and extracellular signal regulated kinase 1/2 , demonstrating that Janus kinase 2 was the upstream effector of the mitogen activated protein kinase kinase pathway . Positive_regulation MAP2K6 KALRN 15923627 1413999 Furthermore , elevated expression resulted in catalytic activation of TrkA , as demonstrated by in vitro kinase assays and *increased* NGF stimulated cellular activation of Rac , [Mek] , and CREB . Positive_regulation MAP2K6 KDR 14704231 1225429 Localization of and PLD2 in endothelial caveolae is *involved* in VEGF induced phosphorylation of [MEK] and ERK . Positive_regulation MAP2K6 KHSRP 11211234 763825 Phosphorylation of by p38beta2 was *induced* in vitro and in vivo by [MAP kinase kinases (MKK) 6] activation . Positive_regulation MAP2K6 KLF5 17158781 1687877 We show that increases proliferation , transcriptionally up-regulates EGFR , and *activates* [MEK/ERK] signaling , as indicated by increased phosphorylation of MEK and ERK . Positive_regulation MAP2K6 KLF5 17158781 1687886 Thus , *regulates* [MEK/ERK] signaling via EGFR and is also downstream of MAPK signaling , providing a novel mechanism for signal amplification or suppression and control of proliferation in basal cells . Positive_regulation MAP2K6 KMT2A 20362031 2261047 We further showed that endogenous MEK is phosphorylated in a MLL-AF4 expressing leukemia cell line , whereas depletion of by small interfering RNA *reduced* the [phospho-MEK] level . Positive_regulation MAP2K6 KRAS 12391290 1007602 They also inhibited *induced* Raf-1 activation in human embryonic kidney 293 cells , Raf-1 and [mitogen activated protein kinase kinase] 1 activities in HT1080 fibrosarcoma cells , and epidermal growth factor induced Raf-1 activation in A549 lung carcinoma cells . Positive_regulation MAP2K6 KRAS 15308774 1284970 Azido farnesylated proteins maintain the properties of protein farnesylation , including promoting membrane association , *dependent* [mitogen activated protein kinase kinase] activation , and inhibition of lovastatin induced apoptosis . Positive_regulation MAP2K6 KRAS 16041367 1437741 Prohibitin is required for induced [Raf-MEK-ERK] *activation* and epithelial cell migration . Positive_regulation MAP2K6 KRAS 18275061 1924776 As further support for Ras mediated signaling , constitutively active ( ca ) *promoted* [MEK/ERK] activation and osteoclast survival , which was blocked by inhibition of PI3K or Raf . Positive_regulation MAP2K6 KRAS 19022560 2029228 Furthermore , *activation* of Raf-1 , [MEK] and the ERKs by either EGF or ( G12R ) was inhibited by NM23H2 overexpression . Positive_regulation MAP2K6 KRAS 19218870 2039554 Exogenous clusterin stimulates *dependent* [Raf-1/mitogen activated protein kinase kinase] ( MEK ) /ERK activation . Positive_regulation MAP2K6 KRAS 19509115 2098340 Western blot analysis revealed that activation *promoted* the phosphorylation of [Raf/mitogen activated protein kinase kinase-1/2] ( MEK1/2 ) and expression of c-Jun. MEK1/2 inhibitors , U0126 and PD98059 , significantly inhibited the secretion of both CXC chemokines and VEGF , whereas the c-Jun NH ( 2 ) -terminal kinase inhibitor SP600125 abrogated only CXC chemokine production . Positive_regulation MAP2K6 KRAS 20676060 2311800 There , *initiates* activation of [MEK] , which in turn inhibits LIM-kinase 1 activity , thereby allowing dephosphorylation of the F-actin remodelling protein cofilin . Positive_regulation MAP2K6 KRAS 21536655 2440187 Thus , the interaction of LOX-PP with Hsp70 and c-Raf inhibits a critical intermediate in *induced* [MEK] signaling and plays an important role in the function of this tumor suppressor . Positive_regulation MAP2K6 KRAS 22975374 2673995 Without EGFR activity , active levels are not *sufficient* to induce robust [MEK/ERK] activity , a requirement for epithelial transformation . Positive_regulation MAP2K6 KRAS 23546290 2763086 Second , farnesyltransferase inhibitor I , a inhibitor , and U0126 , a [MEK] *inhibitor* , induced an inhibition of the cell proliferation in C6 cells , while the cell proliferation was inhibited by nobiletin as well . Positive_regulation MAP2K6 KRAS 24300897 2877628 The presence of the K-Ras ( G12D ) oncoprotein at a similar abundance to that of endogenous wild-type *results* in only minimal phosphorylation and activation of the canonical Raf-mitogen activated or extracellular signal regulated protein kinase kinase ( [MEK] ) -extracellular signal regulated kinase ( ERK ) and phosphoinositide 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling cascades in primary hematopoietic cells , and these pathways remain dependent on growth factors for efficient activation . Positive_regulation MAP2K6 KRAS 24327733 2880388 Unexpectedly , we found that in PIK3CA mutant and HER2 amplified breast cancers sensitive to PI3K inhibitors , PI3K inhibition led to a rapid suppression of Rac1/p21 activated kinase (PAK)/protein kinase C-RAF ( C-RAF ) / protein kinase MEK ( [MEK] ) /ERK signaling that did not *involve* . Positive_regulation MAP2K6 KRAS 7611406 312091 In conclusion , the activation of MAP kinase by CCK can be explained by activation of [MEK] and may *involve* the activation of by a protein kinase C-dependent mechanism . Positive_regulation MAP2K6 KRAS 7673108 322674 We report here that the cascade of serine kinases activated directly by *results* in a [mitogen activated protein kinase kinase] ( MEK ) -dependent phosphorylation of SOS and subsequent disassociation of the Grb2-SOS complex , thereby interrupting the ability of SOS to catalyze nucleotide exchange on Ras . Positive_regulation MAP2K6 KRAS 7744815 306287 We previously purified a protein factor , named REKS ( Ras dependent Extracellular Signal regulated Kinase ( ERK ) /mitogen activated protein kinase Kinase ( MEK ) Stimulator ) , from Xenopus eggs by use of a cell-free assay system in which recombinant GTP gamma S ( guanosine 5'- ( 3-O-thio ) triphosphate ) <-Ki-Ras> *activates* recombinant [MEK] . Positive_regulation MAP2K6 KRAS 7852306 294418 We have previously identified a protein factor , named REKS ( Ras dependent Extracellular signal regulated kinase/Mitogen activated protein kinase kinase ( MEK ) Stimulator ) , which is necessary for *dependent* [MEK] activation . Positive_regulation MAP2K6 KRAS 8014190 262406 The Raf dependent pathway involves Ras activation , while the Raf independent activation of [MEK] and MAPK does not *involve* . Positive_regulation MAP2K6 KRAS 8182145 256510 One of these pathways involves the activation of , leading to the activation of Raf-1 , and the subsequent *activation* of [MEK] ( MAPK or ERK kinase ) . Positive_regulation MAP2K6 KRAS 8590798 342489 *Activation* of MAPK and [MEK] by Gi2 was blocked by expression of a dominant negative mutant of . Positive_regulation MAP2K6 KRT15 20534855 2289672 Through conserved binding motifs , such as Src homology 2 (SH2) and SH3 binding sites , interacts with cellular proteins , *activates* the NF-kappaB , [MEK/Erk] , and Jun N-terminal protein kinase (JNK) pathways , and induces the expression of several inflammatory and angiogenic genes . Positive_regulation MAP2K6 KSR1 18332145 1904756 IMP concentrations are regulated by Ras through induction of autodegradation and can modulate signal/response thresholds by directly limiting the assembly of functional *dependent* Raf . [MEK] complexes . Positive_regulation MAP2K6 KSR1 18952605 2001067 Overexpression of the mutant in HIRcB cells *inhibited* insulin dependent [MEK] and ERK phosphorylation . Positive_regulation MAP2K6 KSR1 19091743 2060567 These observations suggest that IMP functions as a threshold modulator , controlling sensitivity of the cascade to stimulus by directly limiting the assembly of functional *dependent* [Raf-MEK] complexes . Positive_regulation MAP2K6 KSR1 22177953 2536876 Besides functioning as a scaffold , the kinase activity of is also *required* for [MEK] activation . Positive_regulation MAP2K6 KSR1 23221422 2711113 also *enhances* [Raf-1/MEK/ERK] signaling and is involved in a variety of cellular responses , including cell differentiation , proliferation , and apoptosis . Positive_regulation MAP2K6 KSR2 21441910 2417155 Furthermore , heterodimerization *results* in an increase of BRAF induced [MEK] phosphorylation via the KSR2 mediated relay of a signal from BRAF to release the activation segment of MEK for phosphorylation . Positive_regulation MAP2K6 LEO1 10606930 655869 The results showed that TNF alpha , IL-1 alpha and *induced* serine phosphorylation of MKK3 and [MKK6] , and p38 MAP kinase activation in BECs . Positive_regulation MAP2K6 LEP 19038858 2035247 *stimulated* the phosphorylation of [MEK] ( MAP2K1 ) but not signal transducer and activator of transcription 3 ( STAT3 ) in the cultures , increased the concentration of the suppressor of cytokine signaling 3 ( SOCS3 ) protein , and upregulated metalloproteinase activity . Positive_regulation MAP2K6 LEP 23201486 2736320 Detailed acute and chronic studies with the use of metabolic inhibitors revealed that both JAK/STAT3 and MEK/MAPK but not PI3-K/AKT/GSK-3ß signaling pathways were activated by , and that STAT3 ( Y ( 705 ) P-STAT3 ) and [MEK] ( T ( 202/ ) Y ( 204 ) P-ERK1/2 ) *mediate* these effects . Positive_regulation MAP2K6 LGALS1 21364631 2361014 In this study we first show that *initiates* the activation of c-Jun N-terminal kinase (JNK) , [mitogen activated protein kinase kinase] 4 ( MKK4 ) , and MKK7 as upstream JNK activators in Jurkat T cells . Positive_regulation MAP2K6 LPA 12588763 1059630 Phosphorylation of [mitogen activated protein kinase kinase] ( MEK ) and extracellular signaling regulated kinases ( ERK1/2 ) was rapidly and markedly *induced* by . Positive_regulation MAP2K6 LPA 15205333 1261222 In this article , we demonstrate that *activates* [mitogen activated protein kinase kinase] 1 ( MEKK1 ) in a G ( i ) -Ras dependent manner and that MEKK1 activity is essential for LPA stimulated ovarian cancer cell migration . Positive_regulation MAP2K6 LPA 21832242 2495693 However , inhibition of apical EGFR , but not basolateral EGFR , abrogated *induced* regulation of [MEK] and NHE3 , indicating that LPA ( 5 ) selectively activates apical EGFR . Positive_regulation MAP2K6 LPA 9148952 430041 Inhibition of *stimulated* [MEK] and ERK activation with PD98059 and pertussis toxin , a selective inhibitor of Gi-protein coupled signaling pathways , reduced LPA stimulated MKP-1 expression by only 50 % , suggesting the presence of additional MEK- and ERK independent pathways for MKP-1 expression . Positive_regulation MAP2K6 LPA 9889195 585352 also *induced* the activation of [MAP kinase kinase (MEK)] , but not that of RAF1 , in CHO-DeltaSOS cells . Positive_regulation MAP2K6 LRRK2 20067578 2241604 The increased expression of and MKK6 *requires* [MKK6] activity . Positive_regulation MAP2K6 MAP2K1 12738796 1107254 Here we report that MLK3 can phosphorylate and activate directly in vitro and also can *induce* [MEK] phosphorylation on its activation sites in vivo in COS-7 cells . Positive_regulation MAP2K6 MAP2K1 18463290 1910068 Using 293A cells and in vitro experiments , we detail the formation of a ternary complex of [MEK/ERK/hBVR] , *activation* of and ERK1/2 kinase activities by hBVR , and phosphorylation of hBVR by ERK1/2 . Positive_regulation MAP2K6 MAP2K1 19219045 2044436 The [Mek] heterodimer is negatively *regulated* by Erk mediated phosphorylation of on Thr292 , a residue missing in Mek2 . Positive_regulation MAP2K6 MAP2K1 9430728 482421 Coexpression of or MKK2 with MKP-1 *resulted* in 7-10-fold activation of [mitogen activated protein kinase kinase] ( MKK ) , which required the presence of regulatory serine phosphorylation sites . Positive_regulation MAP2K6 MAP2K7 11085935 750701 Similarly , *activation* of JNK by and p38-MAPK by [Ad-MKK3bE/Ad-MKK6bE] resulted in the increased expression of PGHS-2 . Positive_regulation MAP2K6 MAP3K1 12659851 1073456 MAP3Ks are components of a three tiered protein kinase pathway in which a phosphorylates and *activates* a [mitogen activated protein kinase kinase] ( MAP2K ) , which in turn activates a mitogen activated protein kinase (MAPK) . Positive_regulation MAP2K6 MAP3K1 24777975 2939556 Furthermore , analysis of the signaling events in vitro and in vivo revealed that CARD6 mediated protection against cardiac hypertrophy was attributed to the interruption of mitogen activated protein kinase kinase ( *dependent* [MEK-extracellular] signal regulated protein kinase 1/2 ( ERK1/2 ) and c-Jun N-terminal kinase 1/2 ( JNK1/2 ) activation . Positive_regulation MAP2K6 MAP3K1 24777975 2939565 Altogether , these data indicated that CARD6 serves as a novel cardioprotective factor via negative regulation of *dependent* [MEK-ERK1/2] and JNK1/2 signaling . Positive_regulation MAP2K6 MAP3K10 12659851 1073457 MAP3Ks are components of a three tiered protein kinase pathway in which a phosphorylates and *activates* a [mitogen activated protein kinase kinase] ( MAP2K ) , which in turn activates a mitogen activated protein kinase (MAPK) . Positive_regulation MAP2K6 MAP3K11 12659851 1073458 MAP3Ks are components of a three tiered protein kinase pathway in which a phosphorylates and *activates* a [mitogen activated protein kinase kinase] ( MAP2K ) , which in turn activates a mitogen activated protein kinase (MAPK) . Positive_regulation MAP2K6 MAP3K12 12659851 1073459 MAP3Ks are components of a three tiered protein kinase pathway in which a phosphorylates and *activates* a [mitogen activated protein kinase kinase] ( MAP2K ) , which in turn activates a mitogen activated protein kinase (MAPK) . Positive_regulation MAP2K6 MAP3K13 12659851 1073460 MAP3Ks are components of a three tiered protein kinase pathway in which a phosphorylates and *activates* a [mitogen activated protein kinase kinase] ( MAP2K ) , which in turn activates a mitogen activated protein kinase (MAPK) . Positive_regulation MAP2K6 MAP3K14 12659851 1073461 MAP3Ks are components of a three tiered protein kinase pathway in which a phosphorylates and *activates* a [mitogen activated protein kinase kinase] ( MAP2K ) , which in turn activates a mitogen activated protein kinase (MAPK) . Positive_regulation MAP2K6 MAP3K15 12659851 1073455 MAP3Ks are components of a three tiered protein kinase pathway in which a phosphorylates and *activates* a [mitogen activated protein kinase kinase] ( MAP2K ) , which in turn activates a mitogen activated protein kinase (MAPK) . Positive_regulation MAP2K6 MAP3K19 12659851 1073454 MAP3Ks are components of a three tiered protein kinase pathway in which a phosphorylates and *activates* a [mitogen activated protein kinase kinase] ( MAP2K ) , which in turn activates a mitogen activated protein kinase (MAPK) . Positive_regulation MAP2K6 MAP3K2 12659851 1073462 MAP3Ks are components of a three tiered protein kinase pathway in which a phosphorylates and *activates* a [mitogen activated protein kinase kinase] ( MAP2K ) , which in turn activates a mitogen activated protein kinase (MAPK) . Positive_regulation MAP2K6 MAP3K3 10347227 616832 directly *activates* [MKK6] and MKK7 , specific activators of the p38 and c-Jun NH2-terminal kinases . Positive_regulation MAP2K6 MAP3K3 12659851 1073463 MAP3Ks are components of a three tiered protein kinase pathway in which a phosphorylates and *activates* a [mitogen activated protein kinase kinase] ( MAP2K ) , which in turn activates a mitogen activated protein kinase (MAPK) . Positive_regulation MAP2K6 MAP3K3 9006902 410743 We now demonstrate that *activates* SEK and [MEK] , the known kinases targeting SAPK and ERK , respectively . Positive_regulation MAP2K6 MAP3K4 12659851 1073464 MAP3Ks are components of a three tiered protein kinase pathway in which a phosphorylates and *activates* a [mitogen activated protein kinase kinase] ( MAP2K ) , which in turn activates a mitogen activated protein kinase (MAPK) . Positive_regulation MAP2K6 MAP3K4 9305639 454085 Furthermore , phosphorylated and *activated* [MKK6] and SEK1 in vitro . Positive_regulation MAP2K6 MAP3K5 12659851 1073465 MAP3Ks are components of a three tiered protein kinase pathway in which a phosphorylates and *activates* a [mitogen activated protein kinase kinase] ( MAP2K ) , which in turn activates a mitogen activated protein kinase (MAPK) . Positive_regulation MAP2K6 MAP3K5 20550965 2289943 The MAPKKK , ASK1 , was strongly activated late during ischaemia , with a similar time course to that of MKK6 and in ischaemic neonatal cardiac myocytes expression preferentially *activated* [MKK6] rather than MKK3 . Positive_regulation MAP2K6 MAP3K6 12659851 1073466 MAP3Ks are components of a three tiered protein kinase pathway in which a phosphorylates and *activates* a [mitogen activated protein kinase kinase] ( MAP2K ) , which in turn activates a mitogen activated protein kinase (MAPK) . Positive_regulation MAP2K6 MAP3K7 10504490 648996 *stimulated* [MKK6] and p38K activity and inhibited the percentage of the S and G2/M phases . Positive_regulation MAP2K6 MAP3K7 12659851 1073467 MAP3Ks are components of a three tiered protein kinase pathway in which a phosphorylates and *activates* a [mitogen activated protein kinase kinase] ( MAP2K ) , which in turn activates a mitogen activated protein kinase (MAPK) . Positive_regulation MAP2K6 MAP3K8 12659851 1073468 MAP3Ks are components of a three tiered protein kinase pathway in which a phosphorylates and *activates* a [mitogen activated protein kinase kinase] ( MAP2K ) , which in turn activates a mitogen activated protein kinase (MAPK) . Positive_regulation MAP2K6 MAP3K8 17848581 1817818 We have developed a series of highly selective and potent Tpl2 inhibitors , and in the present study we have used these inhibitors to demonstrate that the catalytic activity of is *required* for the LPS induced activation of [MEK] and ERK in primary human monocytes . Positive_regulation MAP2K6 MAP3K8 19808894 2187076 Pharmacological inhibition or silencing of *prevented* [MEK/ERK1/2] activation by these cytokines but not by insulin , demonstrating its involvement in ERK1/2 activation specifically in response to inflammatory stimuli . Positive_regulation MAP2K6 MAP3K9 12659851 1073469 MAP3Ks are components of a three tiered protein kinase pathway in which a phosphorylates and *activates* a [mitogen activated protein kinase kinase] ( MAP2K ) , which in turn activates a mitogen activated protein kinase (MAPK) . Positive_regulation MAP2K6 MAPK1 10050043 592882 In one set of experiments , we *inhibited* the activation of by pretreating cells with PD098059 , a specific inhibitor of [MEK] ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAP2K6 MAPK1 10601295 574394 In addition , *activation* of p38 by constitutively active [MKK6b] or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAP2K6 MAPK1 10884385 736680 We find that at early time points ( up to 3 h ) in nocodazole induction , [Raf/MEK/MAPK] is activated , and inhibition of activation by a MEK inhibitor , PD98059 or U0126 , *reduces* the number of cells entering mitosis by creating a block at G ( 2 ) . Positive_regulation MAP2K6 MAPK1 11085935 750702 Similarly , *activation* of JNK by Ad-MKK7D and by [Ad-MKK3bE/Ad-MKK6bE] resulted in the increased expression of PGHS-2 . Positive_regulation MAP2K6 MAPK1 11822870 909007 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of pathway inhibitors ( [MEK] *inhibitors* PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAP2K6 MAPK1 12808350 1102429 Adenoviral vector mediated expression of a dominant negative form of p38 significantly *reduced* mural cell recruitment , whereas overexpression of a constitutively activated form of [MKK6] , an upstream activator of p38 MAPK , increased mural cell number . Positive_regulation MAP2K6 MAPK1 14530261 1174710 Expression of COX-2 was partially blocked by U0126 , a [MEK] *inhibitor* , and SB 203580 , a p38 inhibitor . Positive_regulation MAP2K6 MAPK1 15104236 1240251 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 inhibitor , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( [MEK] ) *inhibitor* , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAP2K6 MAPK1 15142632 1247231 Multiple pathways are activated with stimulation of the autocrine and paracrine EGFR loop , from the [ras-raf-MEK] *activation* of to the P13K-Akt pathway , each playing an important role in cancer cell survival , invasion , and angiogenesis . Positive_regulation MAP2K6 MAPK1 15271999 1296333 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation MAP2K6 MAPK1 15304546 1322458 Furthermore , *activation* of by the coexpression of constitutively active [MAPKK/MEK] predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAP2K6 MAPK1 15365248 1294516 Treatment of keratinocytes with PD98059 , [MEK] *inhibitor* , and SB20358 , p38 inhibitor , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAP2K6 MAPK1 15867183 1404227 In cultured cardiac myocytes , specific *activation* of stress activated , p38 , by upstream activator [MKK6bE] led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAP2K6 MAPK1 16157033 1455708 SB203580 , a inhibitor , and U0126 , a [MEK] *inhibitor* , both completely blocked ADM mediated responses in MsC . Positive_regulation MAP2K6 MAPK1 18771907 1962630 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a [MEK] *inhibitor* , and SB203580 , an inhibitor of p38 , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAP2K6 MAPK1 20438834 2282688 This was followed by *activation* of [MKK3/MKK6] and MKK4/MKK7 at 4-8 or 12h and then JNK/p38 at 8 to 12h . Positive_regulation MAP2K6 MAPK1 21769916 2494812 In TGW cells , PD98059 , a [MEK] *inhibitor* , but not SB203580 ( a p38 inhibitor ) and LY294002 ( a PI3K inhibitor ) inhibited GDNF induced GAP43 expression , suggesting the MEK/ERK pathway has a major role in GDNF induced GAP43 transcription . Positive_regulation MAP2K6 MAPK1 21892182 2491647 Further , we show that *activation* of p38 by expression of constitutively active [MAP kinase kinase 6] ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAP2K6 MAPK1 22164285 2517895 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of [MKK6] and marked *activation* of p38 . Positive_regulation MAP2K6 MAPK1 22164285 2517921 Our data also demonstrate that the low levels of [MKK6] expressed in resistant cell lines are the *consequence* of high basal activity of p38 mediated by the elevated levels of MKK3 . Positive_regulation MAP2K6 MAPK1 22785235 2691842 TRH induced CRE promoter was inhibited by kinase ( MEK ) inhibitor and was *increased* by overexpression of [MEK kinase (MEKK)] . Positive_regulation MAP2K6 MAPK1 7889302 289391 2. Both nucleotides stimulate phosphorylation and *activation* of and a biphasic phosphorylation of the up-stream [mitogen activated protein kinase kinase] . Positive_regulation MAP2K6 MAPK1 8226933 235362 *Activation* of extracellular signal regulated kinase ( ERK ) or by [MEK] ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAP2K6 MAPK1 8662760 367267 Stimulation of transfected cells with fMLP resulted in the time- and dose dependent increase in tyrosine phosphorylation and activation of ERK1 and and the *activation* of [MEK] , the MAP kinase/ERK kinase . Positive_regulation MAP2K6 MAPK1 9275096 450638 We show here , that in the human neuroblastoma cell line SK-N-SH , the membrane impermeable conjugated 17beta-estradiol ( E2BSA ) activates [mitogen activated protein kinase kinase] ( MAPKK or MEK ) and *induces* the phosphorylation and activation of both ERK-1 and ( mitogen activated protein kinase or MAPK ) . Positive_regulation MAP2K6 MAPK10 10050043 592883 In one set of experiments , we *inhibited* the activation of by pretreating cells with PD098059 , a specific inhibitor of [MEK] ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAP2K6 MAPK10 10601295 574395 In addition , *activation* of p38 by constitutively active [MKK6b] or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAP2K6 MAPK10 10884385 736681 We find that at early time points ( up to 3 h ) in nocodazole induction , [Raf/MEK/MAPK] is activated , and inhibition of activation by a MEK inhibitor , PD98059 or U0126 , *reduces* the number of cells entering mitosis by creating a block at G ( 2 ) . Positive_regulation MAP2K6 MAPK10 11085935 750703 Similarly , *activation* of JNK by Ad-MKK7D and by [Ad-MKK3bE/Ad-MKK6bE] resulted in the increased expression of PGHS-2 . Positive_regulation MAP2K6 MAPK10 11822870 909008 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of pathway inhibitors ( [MEK] *inhibitors* PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAP2K6 MAPK10 12808350 1102430 Adenoviral vector mediated expression of a dominant negative form of p38 significantly *reduced* mural cell recruitment , whereas overexpression of a constitutively activated form of [MKK6] , an upstream activator of p38 MAPK , increased mural cell number . Positive_regulation MAP2K6 MAPK10 14530261 1174711 Expression of COX-2 was partially blocked by U0126 , a [MEK] *inhibitor* , and SB 203580 , a p38 inhibitor . Positive_regulation MAP2K6 MAPK10 15104236 1240252 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 inhibitor , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( [MEK] ) *inhibitor* , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAP2K6 MAPK10 15271999 1296334 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation MAP2K6 MAPK10 15304546 1322459 Furthermore , *activation* of by the coexpression of constitutively active [MAPKK/MEK] predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAP2K6 MAPK10 15365248 1294517 Treatment of keratinocytes with PD98059 , [MEK] *inhibitor* , and SB20358 , p38 inhibitor , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAP2K6 MAPK10 15867183 1404228 In cultured cardiac myocytes , specific *activation* of stress activated , p38 , by upstream activator [MKK6bE] led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAP2K6 MAPK10 16157033 1455709 SB203580 , a inhibitor , and U0126 , a [MEK] *inhibitor* , both completely blocked ADM mediated responses in MsC . Positive_regulation MAP2K6 MAPK10 18771907 1962631 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a [MEK] *inhibitor* , and SB203580 , an inhibitor of p38 , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAP2K6 MAPK10 20438834 2282689 This was followed by *activation* of [MKK3/MKK6] and MKK4/MKK7 at 4-8 or 12h and then JNK/p38 at 8 to 12h . Positive_regulation MAP2K6 MAPK10 21769916 2494813 In TGW cells , PD98059 , a [MEK] *inhibitor* , but not SB203580 ( a p38 inhibitor ) and LY294002 ( a PI3K inhibitor ) inhibited GDNF induced GAP43 expression , suggesting the MEK/ERK pathway has a major role in GDNF induced GAP43 transcription . Positive_regulation MAP2K6 MAPK10 21892182 2491648 Further , we show that *activation* of p38 by expression of constitutively active [MAP kinase kinase 6] ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAP2K6 MAPK10 22164285 2517896 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of [MKK6] and marked *activation* of p38 . Positive_regulation MAP2K6 MAPK10 22164285 2517922 Our data also demonstrate that the low levels of [MKK6] expressed in resistant cell lines are the *consequence* of high basal activity of p38 mediated by the elevated levels of MKK3 . Positive_regulation MAP2K6 MAPK10 22785235 2691843 TRH induced CRE promoter was inhibited by kinase ( MEK ) inhibitor and was *increased* by overexpression of [MEK kinase (MEKK)] . Positive_regulation MAP2K6 MAPK10 7889302 289392 2. Both nucleotides stimulate phosphorylation and *activation* of and a biphasic phosphorylation of the up-stream [mitogen activated protein kinase kinase] . Positive_regulation MAP2K6 MAPK10 8226933 235363 *Activation* of extracellular signal regulated kinase ( ERK ) or by [MEK] ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAP2K6 MAPK11 10050043 592884 In one set of experiments , we *inhibited* the activation of by pretreating cells with PD098059 , a specific inhibitor of [MEK] ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAP2K6 MAPK11 10601295 574396 In addition , *activation* of p38 by constitutively active [MKK6b] or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAP2K6 MAPK11 10884385 736682 We find that at early time points ( up to 3 h ) in nocodazole induction , [Raf/MEK/MAPK] is activated , and inhibition of activation by a MEK inhibitor , PD98059 or U0126 , *reduces* the number of cells entering mitosis by creating a block at G ( 2 ) . Positive_regulation MAP2K6 MAPK11 11085935 750704 Similarly , *activation* of JNK by Ad-MKK7D and by [Ad-MKK3bE/Ad-MKK6bE] resulted in the increased expression of PGHS-2 . Positive_regulation MAP2K6 MAPK11 11822870 909009 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of pathway inhibitors ( [MEK] *inhibitors* PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAP2K6 MAPK11 12808350 1102431 Adenoviral vector mediated expression of a dominant negative form of p38 significantly *reduced* mural cell recruitment , whereas overexpression of a constitutively activated form of [MKK6] , an upstream activator of p38 MAPK , increased mural cell number . Positive_regulation MAP2K6 MAPK11 14530261 1174712 Expression of COX-2 was partially blocked by U0126 , a [MEK] *inhibitor* , and SB 203580 , a p38 inhibitor . Positive_regulation MAP2K6 MAPK11 15104236 1240253 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 inhibitor , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( [MEK] ) *inhibitor* , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAP2K6 MAPK11 15271999 1296335 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation MAP2K6 MAPK11 15304546 1322460 Furthermore , *activation* of by the coexpression of constitutively active [MAPKK/MEK] predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAP2K6 MAPK11 15365248 1294518 Treatment of keratinocytes with PD98059 , [MEK] *inhibitor* , and SB20358 , p38 inhibitor , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAP2K6 MAPK11 15867183 1404229 In cultured cardiac myocytes , specific *activation* of stress activated , p38 , by upstream activator [MKK6bE] led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAP2K6 MAPK11 16157033 1455710 SB203580 , a inhibitor , and U0126 , a [MEK] *inhibitor* , both completely blocked ADM mediated responses in MsC . Positive_regulation MAP2K6 MAPK11 18771907 1962632 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a [MEK] *inhibitor* , and SB203580 , an inhibitor of p38 , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAP2K6 MAPK11 20438834 2282690 This was followed by *activation* of [MKK3/MKK6] and MKK4/MKK7 at 4-8 or 12h and then JNK/p38 at 8 to 12h . Positive_regulation MAP2K6 MAPK11 21769916 2494814 In TGW cells , PD98059 , a [MEK] *inhibitor* , but not SB203580 ( a p38 inhibitor ) and LY294002 ( a PI3K inhibitor ) inhibited GDNF induced GAP43 expression , suggesting the MEK/ERK pathway has a major role in GDNF induced GAP43 transcription . Positive_regulation MAP2K6 MAPK11 21892182 2491649 Further , we show that *activation* of p38 by expression of constitutively active [MAP kinase kinase 6] ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAP2K6 MAPK11 22164285 2517897 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of [MKK6] and marked *activation* of p38 . Positive_regulation MAP2K6 MAPK11 22164285 2517923 Our data also demonstrate that the low levels of [MKK6] expressed in resistant cell lines are the *consequence* of high basal activity of p38 mediated by the elevated levels of MKK3 . Positive_regulation MAP2K6 MAPK11 22785235 2691844 TRH induced CRE promoter was inhibited by kinase ( MEK ) inhibitor and was *increased* by overexpression of [MEK kinase (MEKK)] . Positive_regulation MAP2K6 MAPK11 7889302 289393 2. Both nucleotides stimulate phosphorylation and *activation* of and a biphasic phosphorylation of the up-stream [mitogen activated protein kinase kinase] . Positive_regulation MAP2K6 MAPK11 8226933 235364 *Activation* of extracellular signal regulated kinase ( ERK ) or by [MEK] ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAP2K6 MAPK12 10050043 592885 In one set of experiments , we *inhibited* the activation of by pretreating cells with PD098059 , a specific inhibitor of [MEK] ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAP2K6 MAPK12 10601295 574397 In addition , *activation* of p38 by constitutively active [MKK6b] or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAP2K6 MAPK12 10884385 736683 We find that at early time points ( up to 3 h ) in nocodazole induction , [Raf/MEK/MAPK] is activated , and inhibition of activation by a MEK inhibitor , PD98059 or U0126 , *reduces* the number of cells entering mitosis by creating a block at G ( 2 ) . Positive_regulation MAP2K6 MAPK12 11085935 750705 Similarly , *activation* of JNK by Ad-MKK7D and by [Ad-MKK3bE/Ad-MKK6bE] resulted in the increased expression of PGHS-2 . Positive_regulation MAP2K6 MAPK12 11822870 909010 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of pathway inhibitors ( [MEK] *inhibitors* PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAP2K6 MAPK12 12808350 1102432 Adenoviral vector mediated expression of a dominant negative form of p38 significantly *reduced* mural cell recruitment , whereas overexpression of a constitutively activated form of [MKK6] , an upstream activator of p38 MAPK , increased mural cell number . Positive_regulation MAP2K6 MAPK12 14530261 1174713 Expression of COX-2 was partially blocked by U0126 , a [MEK] *inhibitor* , and SB 203580 , a p38 inhibitor . Positive_regulation MAP2K6 MAPK12 15104236 1240254 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 inhibitor , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( [MEK] ) *inhibitor* , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAP2K6 MAPK12 15271999 1296336 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation MAP2K6 MAPK12 15304546 1322461 Furthermore , *activation* of by the coexpression of constitutively active [MAPKK/MEK] predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAP2K6 MAPK12 15365248 1294519 Treatment of keratinocytes with PD98059 , [MEK] *inhibitor* , and SB20358 , p38 inhibitor , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAP2K6 MAPK12 15867183 1404230 In cultured cardiac myocytes , specific *activation* of stress activated , p38 , by upstream activator [MKK6bE] led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAP2K6 MAPK12 16157033 1455711 SB203580 , a inhibitor , and U0126 , a [MEK] *inhibitor* , both completely blocked ADM mediated responses in MsC . Positive_regulation MAP2K6 MAPK12 18771907 1962633 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a [MEK] *inhibitor* , and SB203580 , an inhibitor of p38 , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAP2K6 MAPK12 20438834 2282691 This was followed by *activation* of [MKK3/MKK6] and MKK4/MKK7 at 4-8 or 12h and then JNK/p38 at 8 to 12h . Positive_regulation MAP2K6 MAPK12 21769916 2494815 In TGW cells , PD98059 , a [MEK] *inhibitor* , but not SB203580 ( a p38 inhibitor ) and LY294002 ( a PI3K inhibitor ) inhibited GDNF induced GAP43 expression , suggesting the MEK/ERK pathway has a major role in GDNF induced GAP43 transcription . Positive_regulation MAP2K6 MAPK12 21892182 2491650 Further , we show that *activation* of p38 by expression of constitutively active [MAP kinase kinase 6] ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAP2K6 MAPK12 22164285 2517898 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of [MKK6] and marked *activation* of p38 . Positive_regulation MAP2K6 MAPK12 22164285 2517924 Our data also demonstrate that the low levels of [MKK6] expressed in resistant cell lines are the *consequence* of high basal activity of p38 mediated by the elevated levels of MKK3 . Positive_regulation MAP2K6 MAPK12 22785235 2691845 TRH induced CRE promoter was inhibited by kinase ( MEK ) inhibitor and was *increased* by overexpression of [MEK kinase (MEKK)] . Positive_regulation MAP2K6 MAPK12 7889302 289394 2. Both nucleotides stimulate phosphorylation and *activation* of and a biphasic phosphorylation of the up-stream [mitogen activated protein kinase kinase] . Positive_regulation MAP2K6 MAPK12 8226933 235365 *Activation* of extracellular signal regulated kinase ( ERK ) or by [MEK] ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAP2K6 MAPK13 10050043 592886 In one set of experiments , we *inhibited* the activation of by pretreating cells with PD098059 , a specific inhibitor of [MEK] ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAP2K6 MAPK13 10601295 574398 In addition , *activation* of p38 by constitutively active [MKK6b] or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAP2K6 MAPK13 10884385 736684 We find that at early time points ( up to 3 h ) in nocodazole induction , [Raf/MEK/MAPK] is activated , and inhibition of activation by a MEK inhibitor , PD98059 or U0126 , *reduces* the number of cells entering mitosis by creating a block at G ( 2 ) . Positive_regulation MAP2K6 MAPK13 11085935 750706 Similarly , *activation* of JNK by Ad-MKK7D and by [Ad-MKK3bE/Ad-MKK6bE] resulted in the increased expression of PGHS-2 . Positive_regulation MAP2K6 MAPK13 11822870 909011 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of pathway inhibitors ( [MEK] *inhibitors* PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAP2K6 MAPK13 12808350 1102433 Adenoviral vector mediated expression of a dominant negative form of p38 significantly *reduced* mural cell recruitment , whereas overexpression of a constitutively activated form of [MKK6] , an upstream activator of p38 MAPK , increased mural cell number . Positive_regulation MAP2K6 MAPK13 14530261 1174714 Expression of COX-2 was partially blocked by U0126 , a [MEK] *inhibitor* , and SB 203580 , a p38 inhibitor . Positive_regulation MAP2K6 MAPK13 15104236 1240255 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 inhibitor , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( [MEK] ) *inhibitor* , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAP2K6 MAPK13 15271999 1296337 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation MAP2K6 MAPK13 15304546 1322462 Furthermore , *activation* of by the coexpression of constitutively active [MAPKK/MEK] predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAP2K6 MAPK13 15365248 1294520 Treatment of keratinocytes with PD98059 , [MEK] *inhibitor* , and SB20358 , p38 inhibitor , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAP2K6 MAPK13 15867183 1404231 In cultured cardiac myocytes , specific *activation* of stress activated , p38 , by upstream activator [MKK6bE] led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAP2K6 MAPK13 16157033 1455712 SB203580 , a inhibitor , and U0126 , a [MEK] *inhibitor* , both completely blocked ADM mediated responses in MsC . Positive_regulation MAP2K6 MAPK13 18771907 1962634 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a [MEK] *inhibitor* , and SB203580 , an inhibitor of p38 , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAP2K6 MAPK13 20438834 2282692 This was followed by *activation* of [MKK3/MKK6] and MKK4/MKK7 at 4-8 or 12h and then JNK/p38 at 8 to 12h . Positive_regulation MAP2K6 MAPK13 21769916 2494816 In TGW cells , PD98059 , a [MEK] *inhibitor* , but not SB203580 ( a p38 inhibitor ) and LY294002 ( a PI3K inhibitor ) inhibited GDNF induced GAP43 expression , suggesting the MEK/ERK pathway has a major role in GDNF induced GAP43 transcription . Positive_regulation MAP2K6 MAPK13 21892182 2491651 Further , we show that *activation* of p38 by expression of constitutively active [MAP kinase kinase 6] ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAP2K6 MAPK13 22164285 2517899 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of [MKK6] and marked *activation* of p38 . Positive_regulation MAP2K6 MAPK13 22164285 2517925 Our data also demonstrate that the low levels of [MKK6] expressed in resistant cell lines are the *consequence* of high basal activity of p38 mediated by the elevated levels of MKK3 . Positive_regulation MAP2K6 MAPK13 22785235 2691846 TRH induced CRE promoter was inhibited by kinase ( MEK ) inhibitor and was *increased* by overexpression of [MEK kinase (MEKK)] . Positive_regulation MAP2K6 MAPK13 7889302 289395 2. Both nucleotides stimulate phosphorylation and *activation* of and a biphasic phosphorylation of the up-stream [mitogen activated protein kinase kinase] . Positive_regulation MAP2K6 MAPK13 8226933 235366 *Activation* of extracellular signal regulated kinase ( ERK ) or by [MEK] ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAP2K6 MAPK14 10050043 592887 In one set of experiments , we *inhibited* the activation of by pretreating cells with PD098059 , a specific inhibitor of [MEK] ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAP2K6 MAPK14 10601295 574399 In addition , *activation* of p38 by constitutively active [MKK6b] or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAP2K6 MAPK14 10884385 736685 We find that at early time points ( up to 3 h ) in nocodazole induction , [Raf/MEK/MAPK] is activated , and inhibition of activation by a MEK inhibitor , PD98059 or U0126 , *reduces* the number of cells entering mitosis by creating a block at G ( 2 ) . Positive_regulation MAP2K6 MAPK14 11085935 750707 Similarly , *activation* of JNK by Ad-MKK7D and by [Ad-MKK3bE/Ad-MKK6bE] resulted in the increased expression of PGHS-2 . Positive_regulation MAP2K6 MAPK14 11822870 909012 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of pathway inhibitors ( [MEK] *inhibitors* PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAP2K6 MAPK14 12808350 1102434 Adenoviral vector mediated expression of a dominant negative form of p38 significantly *reduced* mural cell recruitment , whereas overexpression of a constitutively activated form of [MKK6] , an upstream activator of p38 MAPK , increased mural cell number . Positive_regulation MAP2K6 MAPK14 14530261 1174715 Expression of COX-2 was partially blocked by U0126 , a [MEK] *inhibitor* , and SB 203580 , a p38 inhibitor . Positive_regulation MAP2K6 MAPK14 15104236 1240256 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 inhibitor , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( [MEK] ) *inhibitor* , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAP2K6 MAPK14 15271999 1296338 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation MAP2K6 MAPK14 15304546 1322463 Furthermore , *activation* of by the coexpression of constitutively active [MAPKK/MEK] predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAP2K6 MAPK14 15365248 1294521 Treatment of keratinocytes with PD98059 , [MEK] *inhibitor* , and SB20358 , p38 inhibitor , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAP2K6 MAPK14 15867183 1404232 In cultured cardiac myocytes , specific *activation* of stress activated , p38 , by upstream activator [MKK6bE] led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAP2K6 MAPK14 16157033 1455713 SB203580 , a inhibitor , and U0126 , a [MEK] *inhibitor* , both completely blocked ADM mediated responses in MsC . Positive_regulation MAP2K6 MAPK14 18771907 1962635 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a [MEK] *inhibitor* , and SB203580 , an inhibitor of p38 , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAP2K6 MAPK14 20438834 2282693 This was followed by *activation* of [MKK3/MKK6] and MKK4/MKK7 at 4-8 or 12h and then JNK/p38 at 8 to 12h . Positive_regulation MAP2K6 MAPK14 21769916 2494817 In TGW cells , PD98059 , a [MEK] *inhibitor* , but not SB203580 ( a p38 inhibitor ) and LY294002 ( a PI3K inhibitor ) inhibited GDNF induced GAP43 expression , suggesting the MEK/ERK pathway has a major role in GDNF induced GAP43 transcription . Positive_regulation MAP2K6 MAPK14 21892182 2491652 Further , we show that *activation* of p38 by expression of constitutively active [MAP kinase kinase 6] ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAP2K6 MAPK14 22164285 2517900 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of [MKK6] and marked *activation* of p38 . Positive_regulation MAP2K6 MAPK14 22164285 2517926 Our data also demonstrate that the low levels of [MKK6] expressed in resistant cell lines are the *consequence* of high basal activity of p38 mediated by the elevated levels of MKK3 . Positive_regulation MAP2K6 MAPK14 22785235 2691847 TRH induced CRE promoter was inhibited by kinase ( MEK ) inhibitor and was *increased* by overexpression of [MEK kinase (MEKK)] . Positive_regulation MAP2K6 MAPK14 7889302 289396 2. Both nucleotides stimulate phosphorylation and *activation* of and a biphasic phosphorylation of the up-stream [mitogen activated protein kinase kinase] . Positive_regulation MAP2K6 MAPK14 8226933 235367 *Activation* of extracellular signal regulated kinase ( ERK ) or by [MEK] ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAP2K6 MAPK15 10050043 592881 In one set of experiments , we *inhibited* the activation of by pretreating cells with PD098059 , a specific inhibitor of [MEK] ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAP2K6 MAPK15 10601295 574393 In addition , *activation* of p38 by constitutively active [MKK6b] or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAP2K6 MAPK15 10884385 736679 We find that at early time points ( up to 3 h ) in nocodazole induction , [Raf/MEK/MAPK] is activated , and inhibition of activation by a MEK inhibitor , PD98059 or U0126 , *reduces* the number of cells entering mitosis by creating a block at G ( 2 ) . Positive_regulation MAP2K6 MAPK15 11085935 750700 Similarly , *activation* of JNK by Ad-MKK7D and by [Ad-MKK3bE/Ad-MKK6bE] resulted in the increased expression of PGHS-2 . Positive_regulation MAP2K6 MAPK15 11822870 909006 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of pathway inhibitors ( [MEK] *inhibitors* PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAP2K6 MAPK15 12808350 1102428 Adenoviral vector mediated expression of a dominant negative form of p38 significantly *reduced* mural cell recruitment , whereas overexpression of a constitutively activated form of [MKK6] , an upstream activator of p38 MAPK , increased mural cell number . Positive_regulation MAP2K6 MAPK15 14530261 1174709 Expression of COX-2 was partially blocked by U0126 , a [MEK] *inhibitor* , and SB 203580 , a p38 inhibitor . Positive_regulation MAP2K6 MAPK15 15104236 1240249 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 inhibitor , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( [MEK] ) *inhibitor* , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAP2K6 MAPK15 15271999 1296332 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation MAP2K6 MAPK15 15304546 1322456 Furthermore , *activation* of by the coexpression of constitutively active [MAPKK/MEK] predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAP2K6 MAPK15 15365248 1294514 Treatment of keratinocytes with PD98059 , [MEK] *inhibitor* , and SB20358 , p38 inhibitor , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAP2K6 MAPK15 15867183 1404226 In cultured cardiac myocytes , specific *activation* of stress activated , p38 , by upstream activator [MKK6bE] led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAP2K6 MAPK15 16157033 1455706 SB203580 , a inhibitor , and U0126 , a [MEK] *inhibitor* , both completely blocked ADM mediated responses in MsC . Positive_regulation MAP2K6 MAPK15 18771907 1962629 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a [MEK] *inhibitor* , and SB203580 , an inhibitor of p38 , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAP2K6 MAPK15 20438834 2282687 This was followed by *activation* of [MKK3/MKK6] and MKK4/MKK7 at 4-8 or 12h and then JNK/p38 at 8 to 12h . Positive_regulation MAP2K6 MAPK15 21769916 2494810 In TGW cells , PD98059 , a [MEK] *inhibitor* , but not SB203580 ( a p38 inhibitor ) and LY294002 ( a PI3K inhibitor ) inhibited GDNF induced GAP43 expression , suggesting the MEK/ERK pathway has a major role in GDNF induced GAP43 transcription . Positive_regulation MAP2K6 MAPK15 21892182 2491646 Further , we show that *activation* of p38 by expression of constitutively active [MAP kinase kinase 6] ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAP2K6 MAPK15 22164285 2517894 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of [MKK6] and marked *activation* of p38 . Positive_regulation MAP2K6 MAPK15 22164285 2517920 Our data also demonstrate that the low levels of [MKK6] expressed in resistant cell lines are the *consequence* of high basal activity of p38 mediated by the elevated levels of MKK3 . Positive_regulation MAP2K6 MAPK15 22785235 2691840 TRH induced CRE promoter was inhibited by kinase ( MEK ) inhibitor and was *increased* by overexpression of [MEK kinase (MEKK)] . Positive_regulation MAP2K6 MAPK15 7889302 289390 2. Both nucleotides stimulate phosphorylation and *activation* of and a biphasic phosphorylation of the up-stream [mitogen activated protein kinase kinase] . Positive_regulation MAP2K6 MAPK15 8226933 235361 *Activation* of extracellular signal regulated kinase ( ERK ) or by [MEK] ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAP2K6 MAPK3 10050043 592888 In one set of experiments , we *inhibited* the activation of by pretreating cells with PD098059 , a specific inhibitor of [MEK] ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAP2K6 MAPK3 10601295 574400 In addition , *activation* of p38 by constitutively active [MKK6b] or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAP2K6 MAPK3 10884385 736686 We find that at early time points ( up to 3 h ) in nocodazole induction , [Raf/MEK/MAPK] is activated , and inhibition of activation by a MEK inhibitor , PD98059 or U0126 , *reduces* the number of cells entering mitosis by creating a block at G ( 2 ) . Positive_regulation MAP2K6 MAPK3 11085935 750708 Similarly , *activation* of JNK by Ad-MKK7D and by [Ad-MKK3bE/Ad-MKK6bE] resulted in the increased expression of PGHS-2 . Positive_regulation MAP2K6 MAPK3 11822870 909013 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of pathway inhibitors ( [MEK] *inhibitors* PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAP2K6 MAPK3 12808350 1102435 Adenoviral vector mediated expression of a dominant negative form of p38 significantly *reduced* mural cell recruitment , whereas overexpression of a constitutively activated form of [MKK6] , an upstream activator of p38 MAPK , increased mural cell number . Positive_regulation MAP2K6 MAPK3 14530261 1174716 Expression of COX-2 was partially blocked by U0126 , a [MEK] *inhibitor* , and SB 203580 , a p38 inhibitor . Positive_regulation MAP2K6 MAPK3 15104236 1240257 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 inhibitor , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( [MEK] ) *inhibitor* , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAP2K6 MAPK3 15142632 1247232 Multiple pathways are activated with stimulation of the autocrine and paracrine EGFR loop , from the [ras-raf-MEK] *activation* of to the P13K-Akt pathway , each playing an important role in cancer cell survival , invasion , and angiogenesis . Positive_regulation MAP2K6 MAPK3 15271999 1296339 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation MAP2K6 MAPK3 15304546 1322464 Furthermore , *activation* of by the coexpression of constitutively active [MAPKK/MEK] predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAP2K6 MAPK3 15365248 1294522 Treatment of keratinocytes with PD98059 , [MEK] *inhibitor* , and SB20358 , p38 inhibitor , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAP2K6 MAPK3 15867183 1404233 In cultured cardiac myocytes , specific *activation* of stress activated , p38 , by upstream activator [MKK6bE] led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAP2K6 MAPK3 16135787 1450360 Similarly , *promoted* [MEK] binding to IQGAP1 , but either MEK protein altered the association between IQGAP1 and ERK . Positive_regulation MAP2K6 MAPK3 16157033 1455714 SB203580 , a inhibitor , and U0126 , a [MEK] *inhibitor* , both completely blocked ADM mediated responses in MsC . Positive_regulation MAP2K6 MAPK3 18463290 1910069 Using 293A cells and in vitro experiments , we detail the formation of a ternary complex of [MEK/ERK/hBVR] , *activation* of MEK1 and kinase activities by hBVR , and phosphorylation of hBVR by ERK1/2 . Positive_regulation MAP2K6 MAPK3 18771907 1962636 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a [MEK] *inhibitor* , and SB203580 , an inhibitor of p38 , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAP2K6 MAPK3 20438834 2282694 This was followed by *activation* of [MKK3/MKK6] and MKK4/MKK7 at 4-8 or 12h and then JNK/p38 at 8 to 12h . Positive_regulation MAP2K6 MAPK3 21769916 2494818 In TGW cells , PD98059 , a [MEK] *inhibitor* , but not SB203580 ( a p38 inhibitor ) and LY294002 ( a PI3K inhibitor ) inhibited GDNF induced GAP43 expression , suggesting the MEK/ERK pathway has a major role in GDNF induced GAP43 transcription . Positive_regulation MAP2K6 MAPK3 21892182 2491653 Further , we show that *activation* of p38 by expression of constitutively active [MAP kinase kinase 6] ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAP2K6 MAPK3 22164285 2517901 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of [MKK6] and marked *activation* of p38 . Positive_regulation MAP2K6 MAPK3 22164285 2517927 Our data also demonstrate that the low levels of [MKK6] expressed in resistant cell lines are the *consequence* of high basal activity of p38 mediated by the elevated levels of MKK3 . Positive_regulation MAP2K6 MAPK3 22785235 2691848 TRH induced CRE promoter was inhibited by kinase ( MEK ) inhibitor and was *increased* by overexpression of [MEK kinase (MEKK)] . Positive_regulation MAP2K6 MAPK3 7889302 289397 2. Both nucleotides stimulate phosphorylation and *activation* of and a biphasic phosphorylation of the up-stream [mitogen activated protein kinase kinase] . Positive_regulation MAP2K6 MAPK3 8226933 235368 *Activation* of extracellular signal regulated kinase ( ERK ) or by [MEK] ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAP2K6 MAPK3 8662760 367268 Stimulation of transfected cells with fMLP resulted in the time- and dose dependent increase in tyrosine phosphorylation and activation of and ERK2 and the *activation* of [MEK] , the MAP kinase/ERK kinase . Positive_regulation MAP2K6 MAPK3 9275096 450639 We show here , that in the human neuroblastoma cell line SK-N-SH , the membrane impermeable conjugated 17beta-estradiol ( E2BSA ) activates [mitogen activated protein kinase kinase] ( MAPKK or MEK ) and *induces* the phosphorylation and activation of both and ERK-2 ( mitogen activated protein kinase or MAPK ) . Positive_regulation MAP2K6 MAPK4 10050043 592889 In one set of experiments , we *inhibited* the activation of by pretreating cells with PD098059 , a specific inhibitor of [MEK] ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAP2K6 MAPK4 10601295 574401 In addition , *activation* of p38 by constitutively active [MKK6b] or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAP2K6 MAPK4 10884385 736687 We find that at early time points ( up to 3 h ) in nocodazole induction , [Raf/MEK/MAPK] is activated , and inhibition of activation by a MEK inhibitor , PD98059 or U0126 , *reduces* the number of cells entering mitosis by creating a block at G ( 2 ) . Positive_regulation MAP2K6 MAPK4 11085935 750709 Similarly , *activation* of JNK by Ad-MKK7D and by [Ad-MKK3bE/Ad-MKK6bE] resulted in the increased expression of PGHS-2 . Positive_regulation MAP2K6 MAPK4 11822870 909014 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of pathway inhibitors ( [MEK] *inhibitors* PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAP2K6 MAPK4 12808350 1102436 Adenoviral vector mediated expression of a dominant negative form of p38 significantly *reduced* mural cell recruitment , whereas overexpression of a constitutively activated form of [MKK6] , an upstream activator of p38 MAPK , increased mural cell number . Positive_regulation MAP2K6 MAPK4 14530261 1174717 Expression of COX-2 was partially blocked by U0126 , a [MEK] *inhibitor* , and SB 203580 , a p38 inhibitor . Positive_regulation MAP2K6 MAPK4 15104236 1240258 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 inhibitor , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( [MEK] ) *inhibitor* , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAP2K6 MAPK4 15271999 1296340 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation MAP2K6 MAPK4 15304546 1322465 Furthermore , *activation* of by the coexpression of constitutively active [MAPKK/MEK] predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAP2K6 MAPK4 15365248 1294523 Treatment of keratinocytes with PD98059 , [MEK] *inhibitor* , and SB20358 , p38 inhibitor , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAP2K6 MAPK4 15867183 1404234 In cultured cardiac myocytes , specific *activation* of stress activated , p38 , by upstream activator [MKK6bE] led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAP2K6 MAPK4 16157033 1455715 SB203580 , a inhibitor , and U0126 , a [MEK] *inhibitor* , both completely blocked ADM mediated responses in MsC . Positive_regulation MAP2K6 MAPK4 18771907 1962637 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a [MEK] *inhibitor* , and SB203580 , an inhibitor of p38 , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAP2K6 MAPK4 20438834 2282695 This was followed by *activation* of [MKK3/MKK6] and MKK4/MKK7 at 4-8 or 12h and then JNK/p38 at 8 to 12h . Positive_regulation MAP2K6 MAPK4 21769916 2494819 In TGW cells , PD98059 , a [MEK] *inhibitor* , but not SB203580 ( a p38 inhibitor ) and LY294002 ( a PI3K inhibitor ) inhibited GDNF induced GAP43 expression , suggesting the MEK/ERK pathway has a major role in GDNF induced GAP43 transcription . Positive_regulation MAP2K6 MAPK4 21892182 2491654 Further , we show that *activation* of p38 by expression of constitutively active [MAP kinase kinase 6] ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAP2K6 MAPK4 22164285 2517902 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of [MKK6] and marked *activation* of p38 . Positive_regulation MAP2K6 MAPK4 22164285 2517928 Our data also demonstrate that the low levels of [MKK6] expressed in resistant cell lines are the *consequence* of high basal activity of p38 mediated by the elevated levels of MKK3 . Positive_regulation MAP2K6 MAPK4 22785235 2691849 TRH induced CRE promoter was inhibited by kinase ( MEK ) inhibitor and was *increased* by overexpression of [MEK kinase (MEKK)] . Positive_regulation MAP2K6 MAPK4 7889302 289398 2. Both nucleotides stimulate phosphorylation and *activation* of and a biphasic phosphorylation of the up-stream [mitogen activated protein kinase kinase] . Positive_regulation MAP2K6 MAPK4 8226933 235369 *Activation* of extracellular signal regulated kinase ( ERK ) or by [MEK] ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAP2K6 MAPK6 10050043 592890 In one set of experiments , we *inhibited* the activation of by pretreating cells with PD098059 , a specific inhibitor of [MEK] ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAP2K6 MAPK6 10601295 574402 In addition , *activation* of p38 by constitutively active [MKK6b] or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAP2K6 MAPK6 10884385 736688 We find that at early time points ( up to 3 h ) in nocodazole induction , [Raf/MEK/MAPK] is activated , and inhibition of activation by a MEK inhibitor , PD98059 or U0126 , *reduces* the number of cells entering mitosis by creating a block at G ( 2 ) . Positive_regulation MAP2K6 MAPK6 11085935 750710 Similarly , *activation* of JNK by Ad-MKK7D and by [Ad-MKK3bE/Ad-MKK6bE] resulted in the increased expression of PGHS-2 . Positive_regulation MAP2K6 MAPK6 11822870 909015 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of pathway inhibitors ( [MEK] *inhibitors* PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAP2K6 MAPK6 12808350 1102437 Adenoviral vector mediated expression of a dominant negative form of p38 significantly *reduced* mural cell recruitment , whereas overexpression of a constitutively activated form of [MKK6] , an upstream activator of p38 MAPK , increased mural cell number . Positive_regulation MAP2K6 MAPK6 14530261 1174718 Expression of COX-2 was partially blocked by U0126 , a [MEK] *inhibitor* , and SB 203580 , a p38 inhibitor . Positive_regulation MAP2K6 MAPK6 15104236 1240259 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 inhibitor , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( [MEK] ) *inhibitor* , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAP2K6 MAPK6 15271999 1296341 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation MAP2K6 MAPK6 15304546 1322466 Furthermore , *activation* of by the coexpression of constitutively active [MAPKK/MEK] predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAP2K6 MAPK6 15365248 1294524 Treatment of keratinocytes with PD98059 , [MEK] *inhibitor* , and SB20358 , p38 inhibitor , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAP2K6 MAPK6 15867183 1404235 In cultured cardiac myocytes , specific *activation* of stress activated , p38 , by upstream activator [MKK6bE] led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAP2K6 MAPK6 16157033 1455716 SB203580 , a inhibitor , and U0126 , a [MEK] *inhibitor* , both completely blocked ADM mediated responses in MsC . Positive_regulation MAP2K6 MAPK6 18771907 1962638 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a [MEK] *inhibitor* , and SB203580 , an inhibitor of p38 , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAP2K6 MAPK6 20438834 2282696 This was followed by *activation* of [MKK3/MKK6] and MKK4/MKK7 at 4-8 or 12h and then JNK/p38 at 8 to 12h . Positive_regulation MAP2K6 MAPK6 21769916 2494820 In TGW cells , PD98059 , a [MEK] *inhibitor* , but not SB203580 ( a p38 inhibitor ) and LY294002 ( a PI3K inhibitor ) inhibited GDNF induced GAP43 expression , suggesting the MEK/ERK pathway has a major role in GDNF induced GAP43 transcription . Positive_regulation MAP2K6 MAPK6 21892182 2491655 Further , we show that *activation* of p38 by expression of constitutively active [MAP kinase kinase 6] ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAP2K6 MAPK6 22164285 2517903 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of [MKK6] and marked *activation* of p38 . Positive_regulation MAP2K6 MAPK6 22164285 2517929 Our data also demonstrate that the low levels of [MKK6] expressed in resistant cell lines are the *consequence* of high basal activity of p38 mediated by the elevated levels of MKK3 . Positive_regulation MAP2K6 MAPK6 22785235 2691850 TRH induced CRE promoter was inhibited by kinase ( MEK ) inhibitor and was *increased* by overexpression of [MEK kinase (MEKK)] . Positive_regulation MAP2K6 MAPK6 7889302 289399 2. Both nucleotides stimulate phosphorylation and *activation* of and a biphasic phosphorylation of the up-stream [mitogen activated protein kinase kinase] . Positive_regulation MAP2K6 MAPK6 8226933 235370 *Activation* of extracellular signal regulated kinase ( ERK ) or by [MEK] ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAP2K6 MAPK7 10050043 592891 In one set of experiments , we *inhibited* the activation of by pretreating cells with PD098059 , a specific inhibitor of [MEK] ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAP2K6 MAPK7 10601295 574403 In addition , *activation* of p38 by constitutively active [MKK6b] or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAP2K6 MAPK7 10884385 736689 We find that at early time points ( up to 3 h ) in nocodazole induction , [Raf/MEK/MAPK] is activated , and inhibition of activation by a MEK inhibitor , PD98059 or U0126 , *reduces* the number of cells entering mitosis by creating a block at G ( 2 ) . Positive_regulation MAP2K6 MAPK7 11085935 750711 Similarly , *activation* of JNK by Ad-MKK7D and by [Ad-MKK3bE/Ad-MKK6bE] resulted in the increased expression of PGHS-2 . Positive_regulation MAP2K6 MAPK7 11822870 909016 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of pathway inhibitors ( [MEK] *inhibitors* PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAP2K6 MAPK7 12808350 1102438 Adenoviral vector mediated expression of a dominant negative form of p38 significantly *reduced* mural cell recruitment , whereas overexpression of a constitutively activated form of [MKK6] , an upstream activator of p38 MAPK , increased mural cell number . Positive_regulation MAP2K6 MAPK7 14530261 1174719 Expression of COX-2 was partially blocked by U0126 , a [MEK] *inhibitor* , and SB 203580 , a p38 inhibitor . Positive_regulation MAP2K6 MAPK7 15104236 1240260 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 inhibitor , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( [MEK] ) *inhibitor* , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAP2K6 MAPK7 15271999 1296342 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation MAP2K6 MAPK7 15304546 1322467 Furthermore , *activation* of by the coexpression of constitutively active [MAPKK/MEK] predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAP2K6 MAPK7 15365248 1294525 Treatment of keratinocytes with PD98059 , [MEK] *inhibitor* , and SB20358 , p38 inhibitor , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAP2K6 MAPK7 15867183 1404236 In cultured cardiac myocytes , specific *activation* of stress activated , p38 , by upstream activator [MKK6bE] led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAP2K6 MAPK7 16157033 1455717 SB203580 , a inhibitor , and U0126 , a [MEK] *inhibitor* , both completely blocked ADM mediated responses in MsC . Positive_regulation MAP2K6 MAPK7 18771907 1962639 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a [MEK] *inhibitor* , and SB203580 , an inhibitor of p38 , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAP2K6 MAPK7 20438834 2282697 This was followed by *activation* of [MKK3/MKK6] and MKK4/MKK7 at 4-8 or 12h and then JNK/p38 at 8 to 12h . Positive_regulation MAP2K6 MAPK7 21769916 2494821 In TGW cells , PD98059 , a [MEK] *inhibitor* , but not SB203580 ( a p38 inhibitor ) and LY294002 ( a PI3K inhibitor ) inhibited GDNF induced GAP43 expression , suggesting the MEK/ERK pathway has a major role in GDNF induced GAP43 transcription . Positive_regulation MAP2K6 MAPK7 21892182 2491656 Further , we show that *activation* of p38 by expression of constitutively active [MAP kinase kinase 6] ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAP2K6 MAPK7 22164285 2517904 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of [MKK6] and marked *activation* of p38 . Positive_regulation MAP2K6 MAPK7 22164285 2517930 Our data also demonstrate that the low levels of [MKK6] expressed in resistant cell lines are the *consequence* of high basal activity of p38 mediated by the elevated levels of MKK3 . Positive_regulation MAP2K6 MAPK7 22785235 2691851 TRH induced CRE promoter was inhibited by kinase ( MEK ) inhibitor and was *increased* by overexpression of [MEK kinase (MEKK)] . Positive_regulation MAP2K6 MAPK7 7889302 289400 2. Both nucleotides stimulate phosphorylation and *activation* of and a biphasic phosphorylation of the up-stream [mitogen activated protein kinase kinase] . Positive_regulation MAP2K6 MAPK7 8226933 235371 *Activation* of extracellular signal regulated kinase ( ERK ) or by [MEK] ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAP2K6 MAPK8 10050043 592892 In one set of experiments , we *inhibited* the activation of by pretreating cells with PD098059 , a specific inhibitor of [MEK] ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAP2K6 MAPK8 10601295 574404 In addition , *activation* of p38 by constitutively active [MKK6b] or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAP2K6 MAPK8 10884385 736690 We find that at early time points ( up to 3 h ) in nocodazole induction , [Raf/MEK/MAPK] is activated , and inhibition of activation by a MEK inhibitor , PD98059 or U0126 , *reduces* the number of cells entering mitosis by creating a block at G ( 2 ) . Positive_regulation MAP2K6 MAPK8 11085935 750712 Similarly , *activation* of JNK by Ad-MKK7D and by [Ad-MKK3bE/Ad-MKK6bE] resulted in the increased expression of PGHS-2 . Positive_regulation MAP2K6 MAPK8 11822870 909017 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of pathway inhibitors ( [MEK] *inhibitors* PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAP2K6 MAPK8 12808350 1102439 Adenoviral vector mediated expression of a dominant negative form of p38 significantly *reduced* mural cell recruitment , whereas overexpression of a constitutively activated form of [MKK6] , an upstream activator of p38 MAPK , increased mural cell number . Positive_regulation MAP2K6 MAPK8 14530261 1174720 Expression of COX-2 was partially blocked by U0126 , a [MEK] *inhibitor* , and SB 203580 , a p38 inhibitor . Positive_regulation MAP2K6 MAPK8 15104236 1240261 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 inhibitor , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( [MEK] ) *inhibitor* , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAP2K6 MAPK8 15271999 1296343 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation MAP2K6 MAPK8 15304546 1322468 Furthermore , *activation* of by the coexpression of constitutively active [MAPKK/MEK] predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAP2K6 MAPK8 15365248 1294526 Treatment of keratinocytes with PD98059 , [MEK] *inhibitor* , and SB20358 , p38 inhibitor , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAP2K6 MAPK8 15867183 1404237 In cultured cardiac myocytes , specific *activation* of stress activated , p38 , by upstream activator [MKK6bE] led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAP2K6 MAPK8 16157033 1455718 SB203580 , a inhibitor , and U0126 , a [MEK] *inhibitor* , both completely blocked ADM mediated responses in MsC . Positive_regulation MAP2K6 MAPK8 18771907 1962640 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a [MEK] *inhibitor* , and SB203580 , an inhibitor of p38 , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAP2K6 MAPK8 20438834 2282698 This was followed by *activation* of [MKK3/MKK6] and MKK4/MKK7 at 4-8 or 12h and then JNK/p38 at 8 to 12h . Positive_regulation MAP2K6 MAPK8 21769916 2494822 In TGW cells , PD98059 , a [MEK] *inhibitor* , but not SB203580 ( a p38 inhibitor ) and LY294002 ( a PI3K inhibitor ) inhibited GDNF induced GAP43 expression , suggesting the MEK/ERK pathway has a major role in GDNF induced GAP43 transcription . Positive_regulation MAP2K6 MAPK8 21892182 2491657 Further , we show that *activation* of p38 by expression of constitutively active [MAP kinase kinase 6] ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAP2K6 MAPK8 22164285 2517905 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of [MKK6] and marked *activation* of p38 . Positive_regulation MAP2K6 MAPK8 22164285 2517931 Our data also demonstrate that the low levels of [MKK6] expressed in resistant cell lines are the *consequence* of high basal activity of p38 mediated by the elevated levels of MKK3 . Positive_regulation MAP2K6 MAPK8 22785235 2691852 TRH induced CRE promoter was inhibited by kinase ( MEK ) inhibitor and was *increased* by overexpression of [MEK kinase (MEKK)] . Positive_regulation MAP2K6 MAPK8 7889302 289401 2. Both nucleotides stimulate phosphorylation and *activation* of and a biphasic phosphorylation of the up-stream [mitogen activated protein kinase kinase] . Positive_regulation MAP2K6 MAPK8 8226933 235372 *Activation* of extracellular signal regulated kinase ( ERK ) or by [MEK] ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAP2K6 MAPK9 10050043 592893 In one set of experiments , we *inhibited* the activation of by pretreating cells with PD098059 , a specific inhibitor of [MEK] ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAP2K6 MAPK9 10601295 574405 In addition , *activation* of p38 by constitutively active [MKK6b] or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAP2K6 MAPK9 10884385 736691 We find that at early time points ( up to 3 h ) in nocodazole induction , [Raf/MEK/MAPK] is activated , and inhibition of activation by a MEK inhibitor , PD98059 or U0126 , *reduces* the number of cells entering mitosis by creating a block at G ( 2 ) . Positive_regulation MAP2K6 MAPK9 11085935 750713 Similarly , *activation* of JNK by Ad-MKK7D and by [Ad-MKK3bE/Ad-MKK6bE] resulted in the increased expression of PGHS-2 . Positive_regulation MAP2K6 MAPK9 11822870 909018 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of pathway inhibitors ( [MEK] *inhibitors* PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAP2K6 MAPK9 12808350 1102440 Adenoviral vector mediated expression of a dominant negative form of p38 significantly *reduced* mural cell recruitment , whereas overexpression of a constitutively activated form of [MKK6] , an upstream activator of p38 MAPK , increased mural cell number . Positive_regulation MAP2K6 MAPK9 14530261 1174721 Expression of COX-2 was partially blocked by U0126 , a [MEK] *inhibitor* , and SB 203580 , a p38 inhibitor . Positive_regulation MAP2K6 MAPK9 15104236 1240262 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 inhibitor , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( [MEK] ) *inhibitor* , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAP2K6 MAPK9 15271999 1296344 IL-13 mediated transcriptional activation of alpha2 ( I ) collagen gene or type I collagen protein up-regulation was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor , LY294002 , or STAT6 antisense oligonucleotide , but not by PD98059 , a specific *inhibitor* of [MEK/ERK] , or SB202190 or SB203580 , specific inhibitors of p38 ; Positive_regulation MAP2K6 MAPK9 15304546 1322469 Furthermore , *activation* of by the coexpression of constitutively active [MAPKK/MEK] predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAP2K6 MAPK9 15365248 1294527 Treatment of keratinocytes with PD98059 , [MEK] *inhibitor* , and SB20358 , p38 inhibitor , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAP2K6 MAPK9 15867183 1404238 In cultured cardiac myocytes , specific *activation* of stress activated , p38 , by upstream activator [MKK6bE] led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAP2K6 MAPK9 16157033 1455719 SB203580 , a inhibitor , and U0126 , a [MEK] *inhibitor* , both completely blocked ADM mediated responses in MsC . Positive_regulation MAP2K6 MAPK9 18771907 1962641 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a [MEK] *inhibitor* , and SB203580 , an inhibitor of p38 , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAP2K6 MAPK9 20438834 2282699 This was followed by *activation* of [MKK3/MKK6] and MKK4/MKK7 at 4-8 or 12h and then JNK/p38 at 8 to 12h . Positive_regulation MAP2K6 MAPK9 21769916 2494823 In TGW cells , PD98059 , a [MEK] *inhibitor* , but not SB203580 ( a p38 inhibitor ) and LY294002 ( a PI3K inhibitor ) inhibited GDNF induced GAP43 expression , suggesting the MEK/ERK pathway has a major role in GDNF induced GAP43 transcription . Positive_regulation MAP2K6 MAPK9 21892182 2491658 Further , we show that *activation* of p38 by expression of constitutively active [MAP kinase kinase 6] ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAP2K6 MAPK9 22164285 2517906 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of [MKK6] and marked *activation* of p38 . Positive_regulation MAP2K6 MAPK9 22164285 2517932 Our data also demonstrate that the low levels of [MKK6] expressed in resistant cell lines are the *consequence* of high basal activity of p38 mediated by the elevated levels of MKK3 . Positive_regulation MAP2K6 MAPK9 22785235 2691853 TRH induced CRE promoter was inhibited by kinase ( MEK ) inhibitor and was *increased* by overexpression of [MEK kinase (MEKK)] . Positive_regulation MAP2K6 MAPK9 7889302 289402 2. Both nucleotides stimulate phosphorylation and *activation* of and a biphasic phosphorylation of the up-stream [mitogen activated protein kinase kinase] . Positive_regulation MAP2K6 MAPK9 8226933 235373 *Activation* of extracellular signal regulated kinase ( ERK ) or by [MEK] ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAP2K6 MAPKAPK3 11328854 808017 In contrast , we observed sustained luteal-phase CREB phosphorylation in vivo , consistent with upstream [MKK6/p38] MAPK activation and *induction* . Positive_regulation MAP2K6 MDM2 21957016 2507318 We show that , in stem-like glioblastoma cells , [MEK] inhibition reduced MDM2 expression and that inhibition of either MEK or *resulted* in p53 activation accompanied by p53 dependent downregulation of MGMT expression . Positive_regulation MAP2K6 MET 12379223 997112 Stimulation with HGF led to activation of as well as to *activation* of PI3-K , PKB/Akt , [MEK] , and the MAP kinases Erk1 and -2 . Positive_regulation MAP2K6 MIPEP 15608143 1369094 *activated* extracellular signal regulated kinase ( ERK ) 1/2 and Akt and both the [mitogen activated protein kinase kinase] 1 ( MEK1 ) and phosphatidylinositol 3-kinase (PI3K) inhibitors 2'-amino-3'-methoxyflavone ( PD98059 ) and wortmannin reduced the neuroprotective effect of MIP-2 . Positive_regulation MAP2K6 MMP9 17072348 1716610 Induction of by TGF-beta-ALK5 signaling *requires* [MEK-ERK] but not JNK , p38 MAPK or Smad4 . Positive_regulation MAP2K6 MMP9 19567397 2104435 The results indicated that JOTO1007 inhibited the levels of son of sevenless homolog 1 (SOS-1) , growth factor receptor bound protein 2 ( GRB2 ) , Ras homolog gene family , member A ( RhoA ) , Rho associated , coiled-coil containing protein kinase 1 ( ROCK-1 ) , focal adhesion kinase ( FAK ) , phosphorylated-c-jun (p-c-jun) , nuclear factor kappa B (NF-kappaB) p65 , cyclooxygenase-2 (COX-2) , extracellular signal regulated kinases 1/2 ( ERK1/2 ) , matrix metalloproteinase-2 (MMP-2) , MMP-7 and but *promoted* the levels of protein kinase C ( PKC ) , phosphoinositide 3-kinases (PI3K) , MAP kinase kinase kinase 3 (MEKK3) , [mitogen activated protein kinase kinase] 7 ( MKK7 ) , c-jun and inducible nitric oxide synthases (iNOS) , while not affecting Ras , phosphorylated-ERK ( p-ERK ) , p38 and c-jun N-terminal kinase 1/2 ( JNK1/2 ) , which finally led to the inhibition of migration and invasion of the Ca Ski cells in vitro . Positive_regulation MAP2K6 MMP9 20413683 2267641 An EGF receptor (EGFR) kinase inhibitor , a RasN17 dominant negative construct , MEK and PI3K inhibitors significantly blocked EGF/EGFR stimulated MMP-9 , cell invasion , and colony formation in U1242 MG cells , suggesting that is *involved* in [EGFR/Ras/MEK] and PI3K/AKT signaling pathway mediated cell invasion and anchorage independent growth in U1242 MG cells . Positive_regulation MAP2K6 MOCOS 17579558 1763989 In enucleated oocytes , the level was dramatically decreased , and both [MEK] and MAPK dephosphorylation were also *induced* . Positive_regulation MAP2K6 MOK 21209080 2391817 We show here that high S100B stimulates murine microglia migration in Boyden chambers via dependent *activation* of Src kinase , Ras , PI3K , [MEK/ERK1/2] , RhoA/ROCK , Rac1/JNK/AP-1 , Rac1/NF-?B , and , to a lesser extent , p38 MAPK . Positive_regulation MAP2K6 MRAS 22121046 2599612 Using constitutively active M-Ras ( Q71L ) containing additional mutations within its effector binding loop , we found that *induces* [MEK/ERK] dependent and -independent Elk1 activation as well as phosphatidylinositol 3 kinase (PI3K)/Akt and JNK/cJun activation in human MCF-7 breast cancer cells . Positive_regulation MAP2K6 MT1H 18339124 1882104 The MT1-CHO model is invaluable to mapping out signaling cascades as mediated through MT1 receptors especially because it separates out [MEK/ERK] 1/2 *activation* by receptors from that of receptor tyrosine kinases . Positive_regulation MAP2K6 MTOR 22178087 2543196 We evaluated the effects of RAD001 , inhibitor , and U0126 , [MEK] *inhibitor* , on cell proliferation and migration of these cells . Positive_regulation MAP2K6 MTOR 24442130 2918062 Inhibition of these pathways utilizing PF-04691502 , a PI3K and inhibitor , and PD-0325901 , a [MEK] *inhibitor* , slowed the tumor growth of PDX models of bladder cancer . Positive_regulation MAP2K6 MUC1 24043631 2857352 In studies of breast cancer cells stably silenced for MUC1 or overexpressing the oncogenic MUC1-C subunit , we demonstrate that is *sufficient* for induction of [MEK] ? ERK signaling and that treatment with a MUC1-C inhibitor suppresses ERK activation . Positive_regulation MAP2K6 MYLIP 24631982 2930372 Reciprocally , levels were *induced* by [MEK] or JNK signaling response to T cell receptor ( TCR ) engagement . Positive_regulation MAP2K6 MYLK 10733514 678412 These results are consistent with the interpretation that [MEK] activates ERK , ERK2 then activates MLCK , and *activates* myosin . Positive_regulation MAP2K6 NA 16166589 1499849 Adaphostin/MG-132 lethality as well as mitochondrial damage , down-regulation of [Raf/MEK/ERK] , and activation of JNK were *attenuated* by the free-radical scavenger , suggesting that oxidative damage plays a functional role in antileukemic effects . Positive_regulation MAP2K6 NCK1 24670066 2930815 We found that down-regulation of *impaired* TCR induced phosphorylation of the kinases Erk and [MEK] , activation of the AP-1 and NFAT transcription factors and subsequently , IL-2 and CD69 expression . Positive_regulation MAP2K6 NFE2L2 20806931 2352143 Inhibition of *activating* upstream kinase [MEK/ERK] by PD98059 weakened DEM mediated induction of CBR3 mRNA . Positive_regulation MAP2K6 NGF 14713289 1181628 NOS inhibitors did not affect *mediated* phosphorylation of [MEK] . Positive_regulation MAP2K6 NGF 15923627 1414000 Furthermore , elevated Kalirin expression resulted in catalytic activation of TrkA , as demonstrated by in vitro kinase assays and increased *stimulated* cellular activation of Rac , [Mek] , and CREB . Positive_regulation MAP2K6 NGF 16408304 1540242 PC12 cell lines stably expressing increased levels of Ndrg4 protein display enhanced *induced* phosphorylation of [MEK] and ERK . Positive_regulation MAP2K6 NGF 17000777 1640948 Reduction of APPL1 or GIPC1 protein levels suppressed *dependent* [MEK] , extracellular signal regulated kinase , and Akt activation and neurite outgrowth in PC12 cells . Positive_regulation MAP2K6 NGF 20170684 2424446 released from target cells activates TrkA on axon terminals and *triggers* activation of PI3K/Akt , [MEK/ERK] , and PLC? ( phospholipase C ) signaling pathways . Positive_regulation MAP2K6 NGF 8529659 336782 Activation of two isoforms of [mitogen activated protein kinase kinase] in *response* to epidermal growth factor and . Positive_regulation MAP2K6 NPM1 15872011 1439742 Polyamine depletion stimulated expression primarily by increasing NPM gene transcription and its mRNA stability , and it *induced* NPM nuclear translocation through activation of phosphorylation of [mitogen activated protein kinase kinase] . Positive_regulation MAP2K6 NPM1 16909118 1692156 The induced [MEK/ERK] *activation* is independent of c-Raf as evidenced by the lack of MEK1/2 and ERK1/2 phosphorylation upon c-Raf inactivation by two different inhibitors , RI and ZM336372 , and by its siRNA mediated depletion . Positive_regulation MAP2K6 NPPA 20802223 2330534 Coexpression of HIK and ( another member of the ANP MAPKKK family ) weakly *activated* [MKK6/ANQ] but that of TES and ANP3 did not . Positive_regulation MAP2K6 NPY4R 15287886 1278221 AMPA mediated neuroprotection is blocked by , an *inhibitor* of src family kinases , LY294002 , a PI3-K inhibitor , or U0126 , a MAPK kinase ( [MEK] ) inhibitor . Positive_regulation MAP2K6 NPY6R 15464232 1305043 Purified cholangiocytes from normal rats were treated in vitro with forskolin in the absence or presence of Rp-cAMPs ( a PKA inhibitor ) , ( an Src inhibitor ) or PD98059 ( a [MEK] *inhibitor* ) . Positive_regulation MAP2K6 NPY6R 23775084 2820312 We show that both chemical suppression and siRNA silencing of in T-cells *resulted* in sustained phosphorylation of [MEK] and ERK following stimulation with phorbol 12-myristate 13-acetate and ionomycin . Positive_regulation MAP2K6 NPY6R 23775084 2820330 Similarly , in SLE T-cells , suppression of *resulted* in increased [MEK/ERK] phosphorylation , enhanced DNMT1 expression and suppressed expression of the methylation-sensitive CD70 gene . Positive_regulation MAP2K6 NPY6R 24508028 2928448 For MKN28 cells diDCP-LA-PI induced reduction of [MEK] phosphorylation and cell viability was *prevented* by knocking-down . Positive_regulation MAP2K6 NRAS 12391290 1007603 They also inhibited *induced* Raf-1 activation in human embryonic kidney 293 cells , Raf-1 and [mitogen activated protein kinase kinase] 1 activities in HT1080 fibrosarcoma cells , and epidermal growth factor induced Raf-1 activation in A549 lung carcinoma cells . Positive_regulation MAP2K6 NRAS 15308774 1284971 Azido farnesylated proteins maintain the properties of protein farnesylation , including promoting membrane association , dependent [mitogen activated protein kinase kinase] *activation* , and inhibition of lovastatin induced apoptosis . Positive_regulation MAP2K6 NRAS 15677464 1388372 In contrast , [Raf-MEK-ERK] and phosphatidylinositol 3-kinase-Akt pathways , which are fundamental to proliferation and differentiation , are *activated* by both H-Ras and . Positive_regulation MAP2K6 NRAS 16041367 1437742 Prohibitin is required for *induced* [Raf-MEK-ERK] activation and epithelial cell migration . Positive_regulation MAP2K6 NRAS 18275061 1924777 As further support for Ras mediated signaling , constitutively active ( ca ) *promoted* [MEK/ERK] activation and osteoclast survival , which was blocked by inhibition of PI3K or Raf . Positive_regulation MAP2K6 NRAS 19022560 2029229 Furthermore , *activation* of Raf-1 , [MEK] and the ERKs by either EGF or ( G12R ) was inhibited by NM23H2 overexpression . Positive_regulation MAP2K6 NRAS 19218870 2039555 Exogenous clusterin stimulates *dependent* [Raf-1/mitogen activated protein kinase kinase] ( MEK ) /ERK activation . Positive_regulation MAP2K6 NRAS 20676060 2311801 There , *initiates* activation of [MEK] , which in turn inhibits LIM-kinase 1 activity , thereby allowing dephosphorylation of the F-actin remodelling protein cofilin . Positive_regulation MAP2K6 NRAS 21536655 2440188 Thus , the interaction of LOX-PP with Hsp70 and c-Raf inhibits a critical intermediate in *induced* [MEK] signaling and plays an important role in the function of this tumor suppressor . Positive_regulation MAP2K6 NRAS 22975374 2673996 Without EGFR activity , active levels are not *sufficient* to induce robust [MEK/ERK] activity , a requirement for epithelial transformation . Positive_regulation MAP2K6 NRAS 23546290 2763087 Second , farnesyltransferase inhibitor I , a inhibitor , and U0126 , a [MEK] *inhibitor* , induced an inhibition of the cell proliferation in C6 cells , while the cell proliferation was inhibited by nobiletin as well . Positive_regulation MAP2K6 NRAS 24327733 2880389 Unexpectedly , we found that in PIK3CA mutant and HER2 amplified breast cancers sensitive to PI3K inhibitors , PI3K inhibition led to a rapid suppression of Rac1/p21 activated kinase (PAK)/protein kinase C-RAF ( C-RAF ) / protein kinase [MEK] ( MEK ) /ERK signaling that did not *involve* . Positive_regulation MAP2K6 NRAS 7611406 312092 In conclusion , the activation of MAP kinase by CCK can be explained by activation of [MEK] and may *involve* the activation of by a protein kinase C-dependent mechanism . Positive_regulation MAP2K6 NRAS 7673108 322675 We report here that the cascade of serine kinases activated directly by *results* in a [mitogen activated protein kinase kinase] ( MEK ) -dependent phosphorylation of SOS and subsequent disassociation of the Grb2-SOS complex , thereby interrupting the ability of SOS to catalyze nucleotide exchange on Ras . Positive_regulation MAP2K6 NRAS 7852306 294419 We have previously identified a protein factor , named REKS ( Ras dependent Extracellular signal regulated kinase/Mitogen activated protein kinase kinase ( MEK ) Stimulator ) , which is necessary for dependent [MEK] *activation* . Positive_regulation MAP2K6 NRAS 8014190 262407 The Raf dependent pathway involves Ras activation , while the Raf independent activation of [MEK] and MAPK does not *involve* . Positive_regulation MAP2K6 NRAS 8182145 256511 One of these pathways involves the activation of , leading to the activation of Raf-1 , and the subsequent *activation* of [MEK] ( MAPK or ERK kinase ) . Positive_regulation MAP2K6 NRAS 8590798 342490 *Activation* of MAPK and [MEK] by Gi2 was blocked by expression of a dominant negative mutant of . Positive_regulation MAP2K6 NRG1 10844033 700412 Phosphatidylinositol 3-kinase ( PI 3-kinase ) and [mitogen activated protein kinase kinase] ( MAPK kinase ) are strongly *activated* in Schwann cells by glial growth factor ( GGF ) , a soluble , and by contact with neurite membranes ; Positive_regulation MAP2K6 NRG2 10844033 700413 Phosphatidylinositol 3-kinase ( PI 3-kinase ) and [mitogen activated protein kinase kinase] ( MAPK kinase ) are strongly *activated* in Schwann cells by glial growth factor ( GGF ) , a soluble , and by contact with neurite membranes ; Positive_regulation MAP2K6 NRG3 10844033 700414 Phosphatidylinositol 3-kinase ( PI 3-kinase ) and [mitogen activated protein kinase kinase] ( MAPK kinase ) are strongly *activated* in Schwann cells by glial growth factor ( GGF ) , a soluble , and by contact with neurite membranes ; Positive_regulation MAP2K6 NRG4 10844033 700411 Phosphatidylinositol 3-kinase ( PI 3-kinase ) and [mitogen activated protein kinase kinase] ( MAPK kinase ) are strongly *activated* in Schwann cells by glial growth factor ( GGF ) , a soluble , and by contact with neurite membranes ; Positive_regulation MAP2K6 NTF3 12930799 1132371 Semaphorin 3F antagonizes *induced* phosphatidylinositol 3-kinase and [mitogen activated protein kinase kinase] signaling : a mechanism for growth cone collapse . Positive_regulation MAP2K6 NTF4 12930799 1132372 Semaphorin 3F antagonizes *induced* phosphatidylinositol 3-kinase and [mitogen activated protein kinase kinase] signaling : a mechanism for growth cone collapse . Positive_regulation MAP2K6 NTRK1 10531399 562207 In contrast , inhibition of TrkA by AG879 or of *dependent* mitogen activated protein kinase [mitogen activated protein kinase kinase] with PD98059 blocked PC12 cell differentiation without affecting A ( 2A ) AR down-regulation , suggesting dissociation between these two phenomena . Positive_regulation MAP2K6 NTRK2 17306467 1705188 The effects of BDNF were mediated by receptor and [mitogen activated protein kinase kinase] ( MEK ) *activation* since culturing neurons with either ( 9S,10R,12R ) -2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo [ 1,2,3-fg : 3',2',1'- kl ] pyrrolo [ 3,4-i ] [ 1,6 ] benzodiazocine-10-carboxylic acid methyl ester ( K252a ) or 2- ( 2-amino-3-methoxyphenyl ) -4H-1-benzopyran-4-one ( PD98059 ) blocked the augmentation in synaptic activity induced by the neurotrophin . Positive_regulation MAP2K6 PAF1 10606930 655867 The results showed that TNF alpha , IL-1 alpha and *induced* serine phosphorylation of MKK3 and [MKK6] , and p38 MAP kinase activation in BECs . Positive_regulation MAP2K6 PAK1 23653349 2805325 These data suggest that can *stimulate* [MEK] activity in a kinase independent manner , probably by serving as a scaffold to facilitate interaction of C-RAF . Positive_regulation MAP2K6 PAK6 15550393 1367769 *Activation* of by [MAP kinase kinase 6] and p38 MAP kinase . Positive_regulation MAP2K6 PAK6 15550393 1367776 The *activation* of by both p38 MAP kinase and [MKK6] suggests that PAK6 plays a role in the cellular response to stress related signals . Positive_regulation MAP2K6 PDGFA 15920755 1497515 *induced* a rapid [MEK] activation followed by phosphorylation of the MEK substrates ERK1/2 while FGF-2 showed a less pronounced and delayed activation . Positive_regulation MAP2K6 PDGFB 15920755 1497516 *induced* a rapid [MEK] activation followed by phosphorylation of the MEK substrates ERK1/2 while FGF-2 showed a less pronounced and delayed activation . Positive_regulation MAP2K6 PDGFB 24337009 2905282 AKF-PD also downregulated *induced* [MEK] , ERK , Akt , and p70S6K phosphorylation in HSCs . Positive_regulation MAP2K6 PDK1 15175348 1273594 The small interference RNA mediated down-regulation of *attenuated* maximum [MEK] and MAPK activities but could not prolong MAPK signaling duration . Positive_regulation MAP2K6 PEA15 10982386 731864 expression in Chinese hamster ovary cells *resulted* in an increased [mitogen activated protein kinase kinase] and ERK activity . Positive_regulation MAP2K6 PEBP4 19197339 2044035 Consistent with the properties of a scaffold , *enhances* the RAF1-MEK interaction and the activation of [MEK] at low expression levels , whereas it inhibits these parameters at higher expression levels . Positive_regulation MAP2K6 PHB 16041367 1437743 is *required* for Ras induced [Raf-MEK-ERK] activation and epithelial cell migration . Positive_regulation MAP2K6 PI3 10620708 657779 We concluded that basal , but not induced MAPK activity is mediated by PI 3-kinase and that this *mediated* [MEK/MAPK] activity is essential for cell survival in quiescent cells . Positive_regulation MAP2K6 PI3 12502866 1033860 Examination of viral DNA entry suggests a *role* for in HHV-8 entry into the target cells and a role for PKC-zeta , [MEK] , and ERK at a post-viral entry stage of infection . Positive_regulation MAP2K6 PI3 12527803 1048468 In summary , H ( 2 ) O ( 2 ) causes endothelial NO* release mediated by cooperative effects between *dependent* eNOS serine 1179 phosphorylation and activation of [MEK/ERK1/2] . Positive_regulation MAP2K6 PI3 15934945 1414689 U0126 , a [mitogen activated protein kinase kinase] 1/2 ( MEK1/2 ) *inhibitor* , and LY294002 , a inhibitor , both inhibited FGF2 induced BrdU incorporation , suggesting that the extracellular signal regulated kinase1/2 ( ERK1/2 ) and PI3K pathways are required for FGF2 induced NP cell proliferation . Positive_regulation MAP2K6 PI3 18620900 2028049 In addition , all these effects could be partially blocked by U0126 , a specific *inhibitor* of [mitogen activated protein kinase kinase] ( MEK or MAPKK ) , or LY294002 , a specific inhibitor of . Positive_regulation MAP2K6 PI3 22249904 2605676 The IGF-1 induced osteoblast proliferation was mediated via both MAPK and Akt pathways because the IGF-1 mediated cell proliferation was blocked by U0126 , an [MEK/MAPK] *inhibitor* , or LY294002 , a inhibitor . Positive_regulation MAP2K6 PI3 23837585 2809034 hydroxy-2-naphthalenylmethylphosphonic acid trisacetoxymethyl ester ( HNMPA ( AM ) 3 ) , an insulin receptor tyrosine kinase activity inhibitor , wortmannin , an inhibitor of , RO318220 , an *inhibitor* of protein kinase C , colchicine , a microtubule depolymerizing agent , PD98059 , an inhibitor of [mitogen activated protein kinase kinase] ( MEK ) , and cycloheximide , an inhibitor of protein synthesis on fresh Krebs Ringer-bicarbonate plus [ U-(14) C ] -2-deoxy-d-glucose ( 0.1 µCi/ml ) . Positive_regulation MAP2K6 PI3 9858556 582031 Activated [MEK] stimulates expression of AP-1 components independently of phosphatidylinositol 3-kinase ( PI3-kinase ) but *requires* a signal To stimulate DNA synthesis . Positive_regulation MAP2K6 PIK3CA 10066754 593690 Analysis of the upstream pathway leading to MEK activation revealed that inhibition of did not *block* c-Raf activation , whereas [MEK] activation was effectively blocked under these conditions . Positive_regulation MAP2K6 PIK3CA 11593401 869837 was *required* for v-Src to activate MEK and [MEK] was required for v-Src to increase expression of cyclins D1 and E . Positive_regulation MAP2K6 PIK3CA 15149544 1351036 Surprisingly , three structurally different inhibitors *block* Ras , [MEK] and Erk activation in PEPs by Epo . Positive_regulation MAP2K6 PIK3CA 15618457 1387783 The inhibitors wortmannin and LY-294002 and an Akt inhibitor , 1-L-6-hydroxymethyl-chiro-inositol 2- ( R ) -2-O-methyl-3-O-octadecylcarbonate , but not a [mitogen activated protein kinase kinase] *inhibitor* PD-98059 , blocked isoproterenol mediated eosinophil survival . Positive_regulation MAP2K6 PIK3CA 18275061 1924750 M-CSF activates Ras to coordinate activation of PI3K and [Raf/MEK/ERK] , since Ras inhibition decreased PI3K activation and inhibition did not *block* M-CSF mediated Ras activation . Positive_regulation MAP2K6 PIK3CA 20561929 2290119 The vasoprotective effect of JP05 through the activation of *dependent* eNOS and [MEK/ERK] pathways in brain endothelial cells . Positive_regulation MAP2K6 PIK3CA 21769916 2494824 In TGW cells , PD98059 , a [MEK] *inhibitor* , but not SB203580 ( a p38 MAPK inhibitor ) and LY294002 ( a inhibitor ) inhibited GDNF induced GAP43 expression , suggesting the MEK/ERK pathway has a major role in GDNF induced GAP43 transcription . Positive_regulation MAP2K6 PIK3CA 24327733 2880339 *regulates* [MEK/ERK] signaling in breast cancer via the Rac-GEF , P-Rex1 . Positive_regulation MAP2K6 PIK3CA 24442130 2918063 Inhibition of these pathways utilizing PF-04691502 , a and mTOR inhibitor , and PD-0325901 , a [MEK] *inhibitor* , slowed the tumor growth of PDX models of bladder cancer . Positive_regulation MAP2K6 PIK3CA 9360986 462432 hGrb10gamma phosphorylation was inhibited by PD98059 , a specific *inhibitor* of [mitogen activated protein kinase kinase] , and wortmannin , a specific inhibitor of . Positive_regulation MAP2K6 PIK3CA 9595422 505958 The effect of ET-1 in suppressing apoptosis was unaffected by any of the following reagents : a phospholipase C inhibitor ( U73122 ) , a tyrosine kinase inhibitor ( ST638 ) , an [MEK] *inhibitor* ( PD98059 ) , a inhibitors ( wortmannin , LY294002 ) . Positive_regulation MAP2K6 PIK3CA 9720763 528559 We report that inhibition of by wortmannin or an inhibitory p85 construct , p85deltaiSH2 , *reduced* the TCR induced Syk dependent activation of Erk2 , as well as the appearance of phospho-Erk and [phospho-Mek] . Positive_regulation MAP2K6 PIK3R1 10066754 593691 Analysis of the upstream pathway leading to MEK activation revealed that inhibition of did not *block* c-Raf activation , whereas [MEK] activation was effectively blocked under these conditions . Positive_regulation MAP2K6 PIK3R1 11593401 869838 was *required* for v-Src to activate [MEK] and MEK was required for v-Src to increase expression of cyclins D1 and E . Positive_regulation MAP2K6 PIK3R1 15149544 1351037 Surprisingly , three structurally different inhibitors *block* Ras , [MEK] and Erk activation in PEPs by Epo . Positive_regulation MAP2K6 PIK3R1 15618457 1387784 The inhibitors wortmannin and LY-294002 and an Akt inhibitor , 1-L-6-hydroxymethyl-chiro-inositol 2- ( R ) -2-O-methyl-3-O-octadecylcarbonate , but not a [mitogen activated protein kinase kinase] *inhibitor* PD-98059 , blocked isoproterenol mediated eosinophil survival . Positive_regulation MAP2K6 PIK3R1 18275061 1924751 M-CSF activates Ras to coordinate activation of PI3K and [Raf/MEK/ERK] , since Ras inhibition decreased PI3K activation and inhibition did not *block* M-CSF mediated Ras activation . Positive_regulation MAP2K6 PIK3R1 20561929 2290120 The vasoprotective effect of JP05 through the activation of *dependent* eNOS and [MEK/ERK] pathways in brain endothelial cells . Positive_regulation MAP2K6 PIK3R1 21769916 2494825 In TGW cells , PD98059 , a [MEK] *inhibitor* , but not SB203580 ( a p38 MAPK inhibitor ) and LY294002 ( a inhibitor ) inhibited GDNF induced GAP43 expression , suggesting the MEK/ERK pathway has a major role in GDNF induced GAP43 transcription . Positive_regulation MAP2K6 PIK3R1 24327733 2880340 *regulates* [MEK/ERK] signaling in breast cancer via the Rac-GEF , P-Rex1 . Positive_regulation MAP2K6 PIK3R1 24442130 2918064 Inhibition of these pathways utilizing PF-04691502 , a and mTOR inhibitor , and PD-0325901 , a [MEK] *inhibitor* , slowed the tumor growth of PDX models of bladder cancer . Positive_regulation MAP2K6 PIK3R1 9360986 462433 hGrb10gamma phosphorylation was inhibited by PD98059 , a specific *inhibitor* of [mitogen activated protein kinase kinase] , and wortmannin , a specific inhibitor of . Positive_regulation MAP2K6 PIK3R1 9595422 505959 The effect of ET-1 in suppressing apoptosis was unaffected by any of the following reagents : a phospholipase C inhibitor ( U73122 ) , a tyrosine kinase inhibitor ( ST638 ) , an [MEK] *inhibitor* ( PD98059 ) , a inhibitors ( wortmannin , LY294002 ) . Positive_regulation MAP2K6 PIK3R1 9720763 528560 We report that inhibition of by wortmannin or an inhibitory p85 construct , p85deltaiSH2 , *reduced* the TCR induced Syk dependent activation of Erk2 , as well as the appearance of phospho-Erk and [phospho-Mek] . Positive_regulation MAP2K6 PKN1 20383193 2267079 Activated Rac1 promoted Erk dependent hyperproliferation by mediated [Mek] *activation* independent of Mek1 phosporylation at serine 298 . Positive_regulation MAP2K6 PKN1 20515799 2270982 In addition , inhibition of *resulted* in abnormal localization of [mitogen activated protein kinase kinase] ( MEK ) . Positive_regulation MAP2K6 PLA2G4A 15780766 1385356 Particle induced formation of AA metabolites and ROS was dependent on [mitogen activated protein kinase kinase] 1 *activation* of as shown by inhibitor studies . Positive_regulation MAP2K6 PLAU 15874933 1405693 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , [MAP kinase kinase (MKK)3/6] , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Positive_regulation MAP2K6 PLAU 17681345 1822241 These latter effects were mediated by induced *activation* of the mitogen activated protein kinase/extracellular signal regulated kinase ( [MEK] ) . Positive_regulation MAP2K6 PLAU 22155455 2542709 uPA downregulated PON1 gene expression via inactivation of peroxisome proliferator activated receptor-? ( PPAR? ) activity , and this effect was dependent on mediated [mitogen activated protein kinase kinase] *activation* . Positive_regulation MAP2K6 PLAU 22155455 2542731 Mechanistic studies showed that *enhanced* [mitogen activated protein kinase kinase-PPAR?] interaction , resulting in PPAR? nuclear export to the cytosol . Positive_regulation MAP2K6 PLD1 12890486 1117323 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Positive_regulation MAP2K6 PLD1 12890486 1117442 Ang1 induced MEK/ERK activation was abrogated when PLD was inhibited , suggesting that *mediates* Ang1 induced [MEK/ERK] activation . Positive_regulation MAP2K6 PLD2 12890486 1117324 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Positive_regulation MAP2K6 PLD2 12890486 1117443 Ang1 induced MEK/ERK activation was abrogated when PLD was inhibited , suggesting that *mediates* Ang1 induced [MEK/ERK] activation . Positive_regulation MAP2K6 PLD2 14704231 1225430 Localization of VEGFR-2 and in endothelial caveolae is *involved* in VEGF induced phosphorylation of [MEK] and ERK . Positive_regulation MAP2K6 PLD3 12890486 1117318 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Positive_regulation MAP2K6 PLD3 12890486 1117437 Ang1 induced MEK/ERK activation was abrogated when PLD was inhibited , suggesting that *mediates* Ang1 induced [MEK/ERK] activation . Positive_regulation MAP2K6 PLD4 12890486 1117319 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Positive_regulation MAP2K6 PLD4 12890486 1117438 Ang1 induced MEK/ERK activation was abrogated when PLD was inhibited , suggesting that *mediates* Ang1 induced [MEK/ERK] activation . Positive_regulation MAP2K6 PLD5 12890486 1117320 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Positive_regulation MAP2K6 PLD5 12890486 1117439 Ang1 induced MEK/ERK activation was abrogated when PLD was inhibited , suggesting that *mediates* Ang1 induced [MEK/ERK] activation . Positive_regulation MAP2K6 PLD6 12890486 1117321 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Positive_regulation MAP2K6 PLD6 12890486 1117440 Ang1 induced MEK/ERK activation was abrogated when PLD was inhibited , suggesting that *mediates* Ang1 induced [MEK/ERK] activation . Positive_regulation MAP2K6 PLG 16225843 1469498 Here we show that *activates* the mitogen activated protein kinases [MEK] and ERK which leads to alpha-enolase (alpha-ENO) gene expression not only in fibroblasts , but also in peripheral blood mononuclear cells . Positive_regulation MAP2K6 POLDIP2 10903976 713456 PD098059 , a mitogen activated and extracellular regulated kinase kinase ( MEK) 1 inhibitor , UO126 , a dual MEK1 [& MEK2] *inhibitor* , and SB203580 , a MAP kinase inhibitor in the IL-1beta dependent release of PGE ( 2 ) . Positive_regulation MAP2K6 POLDIP2 12589052 1059833 Transforming growth factor-beta1 ( TGF-beta ) -induced apoptosis of prostate cancer cells involves Smad7 dependent *activation* of by TGF-beta activated kinase 1 and [mitogen activated protein kinase kinase] 3 . Positive_regulation MAP2K6 POLDIP2 14530261 1174708 Expression of COX-2 was partially blocked by U0126 , a [MEK] *inhibitor* , and SB 203580 , a MAPK inhibitor . Positive_regulation MAP2K6 POLDIP2 23867467 2835243 The intracisternal administration of PD98059 ( 1 , 10µg ) , a [MEK] *inhibitor* , and SB203580 ( 1 , 5µg ) , a inhibitor , also attenuated the number of formalin induced scratches in the second phase in the IL-1ß treated rats . Positive_regulation MAP2K6 PPM1L 12556533 1071626 Ectopic expression of a phosphatase negative mutant of PP2Cepsilon , ( D/A ) , which acted as a dominant negative form , *enhanced* both the association between TAK1 and MKK4 or [MKK6] and the TAK1 induced activation of an AP-1 reporter gene . Positive_regulation MAP2K6 PPP1R3A 19298253 2056072 could *induce* MEK protein expression and the phosphorylation level of [MEK] and ERK significantly in a time- and dose dependent manner . Positive_regulation MAP2K6 PPP1R3A 19298253 2056087 *activated* [MEK] phosphorylation in ER-negative HEK293 cells in a time- and dose dependent manner . Positive_regulation MAP2K6 PPP1R3A 22549169 2643233 significantly increased estrogen receptor dependent alkaline phosphatase activity , activated estrogen response element-luciferase activity , and *induced* the phosphorylation of [mitogen activated protein kinase kinase] , extracellular regulated kinase , and estrogen receptor-a in Ishikawa cells . Positive_regulation MAP2K6 PPP2CA 18272021 1911628 Accordingly , *regulates* acute dose- and time dependent changes in [MEK-ERK-p90RSK] phosphorylation after haloperidol treatment . Positive_regulation MAP2K6 PPP2CA 19465001 2097328 Raf independent , dependent [MEK] *activation* in response to ERK silencing . Positive_regulation MAP2K6 PPP2R1A 18272021 1911629 Accordingly , *regulates* acute dose- and time dependent changes in [MEK-ERK-p90RSK] phosphorylation after haloperidol treatment . Positive_regulation MAP2K6 PPP2R1A 19465001 2097329 Raf independent , *dependent* [MEK] activation in response to ERK silencing . Positive_regulation MAP2K6 PPP2R2B 18272021 1911630 Accordingly , *regulates* acute dose- and time dependent changes in [MEK-ERK-p90RSK] phosphorylation after haloperidol treatment . Positive_regulation MAP2K6 PPP2R2B 19465001 2097330 Raf independent , *dependent* [MEK] activation in response to ERK silencing . Positive_regulation MAP2K6 PRKAA1 17728396 1817124 Taken together , our studies identify novel links between the physiological state of the cell , the *activation* of [MEK] -- > ERK1/2 signaling , and the nucleocytoplasmic distribution of . Positive_regulation MAP2K6 PRKAA1 19520853 2116087 *Activation* of [MEK/ERK] by upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation MAP2K6 PRKAA2 17728396 1817125 Taken together , our studies identify novel links between the physiological state of the cell , the *activation* of [MEK] -- > ERK1/2 signaling , and the nucleocytoplasmic distribution of . Positive_regulation MAP2K6 PRKAA2 19520853 2116088 *Activation* of [MEK/ERK] by upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation MAP2K6 PRKAB1 17728396 1817126 Taken together , our studies identify novel links between the physiological state of the cell , the *activation* of [MEK] -- > ERK1/2 signaling , and the nucleocytoplasmic distribution of . Positive_regulation MAP2K6 PRKAB1 19520853 2116089 *Activation* of [MEK/ERK] by upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation MAP2K6 PRKAB2 17728396 1817127 Taken together , our studies identify novel links between the physiological state of the cell , the *activation* of [MEK] -- > ERK1/2 signaling , and the nucleocytoplasmic distribution of . Positive_regulation MAP2K6 PRKAB2 19520853 2116090 *Activation* of [MEK/ERK] by upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation MAP2K6 PRKACB 21988724 2498110 These findings suggest that dorsomorphin has the potential to induce neuritogenesis in PC12 cells , a response that requires the activation of *dependent* [MEK-ERK1/2] signaling . Positive_regulation MAP2K6 PRKACB 22653837 2700884 Cyclic dependent paradoxical *activation* of [Raf/MEK/ERK] signaling in polycystin-2 defective mice treated with sorafenib . Positive_regulation MAP2K6 PRKACG 21988724 2498111 These findings suggest that dorsomorphin has the potential to induce neuritogenesis in PC12 cells , a response that requires the activation of *dependent* [MEK-ERK1/2] signaling . Positive_regulation MAP2K6 PRKACG 22653837 2700885 Cyclic *dependent* paradoxical activation of [Raf/MEK/ERK] signaling in polycystin-2 defective mice treated with sorafenib . Positive_regulation MAP2K6 PRKAG1 17728396 1817128 Taken together , our studies identify novel links between the physiological state of the cell , the *activation* of [MEK] -- > ERK1/2 signaling , and the nucleocytoplasmic distribution of . Positive_regulation MAP2K6 PRKAG1 19520853 2116091 *Activation* of [MEK/ERK] by upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation MAP2K6 PRKAG2 17728396 1817129 Taken together , our studies identify novel links between the physiological state of the cell , the *activation* of [MEK] -- > ERK1/2 signaling , and the nucleocytoplasmic distribution of . Positive_regulation MAP2K6 PRKAG2 19520853 2116092 *Activation* of [MEK/ERK] by upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation MAP2K6 PRKAR1A 21988724 2498112 These findings suggest that dorsomorphin has the potential to induce neuritogenesis in PC12 cells , a response that requires the activation of *dependent* [MEK-ERK1/2] signaling . Positive_regulation MAP2K6 PRKAR1A 22653837 2700886 Cyclic dependent paradoxical *activation* of [Raf/MEK/ERK] signaling in polycystin-2 defective mice treated with sorafenib . Positive_regulation MAP2K6 PRKAR1B 21988724 2498113 These findings suggest that dorsomorphin has the potential to induce neuritogenesis in PC12 cells , a response that requires the activation of *dependent* [MEK-ERK1/2] signaling . Positive_regulation MAP2K6 PRKAR1B 22653837 2700887 Cyclic *dependent* paradoxical activation of [Raf/MEK/ERK] signaling in polycystin-2 defective mice treated with sorafenib . Positive_regulation MAP2K6 PRKAR2A 21988724 2498114 These findings suggest that dorsomorphin has the potential to induce neuritogenesis in PC12 cells , a response that requires the activation of *dependent* [MEK-ERK1/2] signaling . Positive_regulation MAP2K6 PRKAR2A 22653837 2700888 Cyclic dependent paradoxical *activation* of [Raf/MEK/ERK] signaling in polycystin-2 defective mice treated with sorafenib . Positive_regulation MAP2K6 PRKAR2B 21988724 2498115 These findings suggest that dorsomorphin has the potential to induce neuritogenesis in PC12 cells , a response that requires the activation of *dependent* [MEK-ERK1/2] signaling . Positive_regulation MAP2K6 PRKAR2B 22653837 2700889 Cyclic *dependent* paradoxical activation of [Raf/MEK/ERK] signaling in polycystin-2 defective mice treated with sorafenib . Positive_regulation MAP2K6 PTGS2 16696851 1560402 Together , these findings suggest that the molecular mechanisms of SP release by bradykinin involve the activation of [MEK] , and also *require* the de novo protein synthesis of in DRG neurons . Positive_regulation MAP2K6 PTPN11 20004456 2204328 We find that vGPCR activity results in phosphorylation of regulatory tyrosines in Shp2 and that in turn , is *required* for vGPCR mediated activation of [MEK] , NFkappaB , and AP-1 . Positive_regulation MAP2K6 PVR 15213219 1281535 similarly *enhanced* the platelet derived growth factor induced activation of the [Ras-Raf-MEK-ERK] signaling and shortened the period of the G ( 0 ) /G ( 1 ) phase of the cell cycle in NIH3T3 cells . Positive_regulation MAP2K6 RAC1 21620958 2450434 Further , ET-1 increased ß ( 1 ) -integrin mRNA and protein expression via *dependent* [MEK/ERK] and EGF receptor-PI3K/Akt activation as shown by adenoviral dominant negative Rac1 or overexpression of copper/zinc-superoxide dismutase . Positive_regulation MAP2K6 RAC1 22061968 2547675 *regulates* NT3 stimulated [Mek-Erk] signaling , directing marrow isolated adult multilineage inducible ( MIAMI ) cells toward an early neuronal phenotype . Positive_regulation MAP2K6 RAF1 10066754 593728 Experiments with dominant negative mutants of the Raf isoforms showed that overexpression of dominant negative did not *prevent* [MEK] activation . Positive_regulation MAP2K6 RAF1 10757792 682925 RKIP interfered with [MEK] phosphorylation and *activation* by , resulting in the suppression of both Raf-1 induced transformation and AP-1 dependent transcription . Positive_regulation MAP2K6 RAF1 10990531 732735 *activates* [MEK] ( MAPK kinase ) in the MAPK pathway , and the MEK inhibitor U0126 reduced calcium current by 45 % after 10-15 min , whereas the inactive analogue U0124 had no effect . Positive_regulation MAP2K6 RAF1 12417593 1036329 The increase in MAPK activity and tyrosine phosphorylation caused by 1alpha,25 ( OH ) ( 2 ) D ( 3 ) could be abolished by Ras inhibitor peptide , compound PD 98059 , which prevents the *activation* of [MEK] by , or incubation of cell lysates before 1alpha,25 ( OH ) ( 2 ) D ( 3 ) exposure with an anti-Raf-1 antibody . Positive_regulation MAP2K6 RAF1 12851216 1109594 Activation of in BON-raf cells *led* to a marked induction of phosphorylated [MEK] and ERK1/2 within 48 h. Importantly , raf-1 activation resulted in morphological changes accompanied by a marked decrease in neuroendocrine secretory granules by electronmicroscopy . Positive_regulation MAP2K6 RAF1 14668716 1178160 Activation of in the TT-raf cells *resulted* in high levels of phosphorylated [MEK] and ERK1/2 , a morphologic transdifferentiation , and a decrease in chromogranin A and calcitonin levels that are associated with a reduction in hASH1 production . Positive_regulation MAP2K6 RAF1 15207247 1261428 In this report , we demonstrate , using two potent and selective inhibitors of [MEK] *activation* by ( PD-098059 ) and p38 ( SB-203580 ) , that both ERK1/2 and p38 pathways play a key role in the production of IL-8 by porins and LPS . Positive_regulation MAP2K6 RAF1 15313400 1285455 RKIP binds inhibits *mediated* phosphorylation of [MEK] through binding to Raf-1 . Positive_regulation MAP2K6 RAF1 15749869 1379700 Although BCR induced c-Raf phosphorylation was also enhanced by prior CD40L treatment , was not *required* for [MEK/ERK] phosphorylation . Positive_regulation MAP2K6 RAF1 20028985 2210941 Raf kinase inhibitor protein (RKIP) inhibits *activation* of [MEK] by and its downstream signal transduction , resulting in blocking the MAP kinase pathway . Positive_regulation MAP2K6 RAF1 21288261 2419835 Using two potent and selective inhibitors of [MEK] *activation* by ( PD-098059 ) and p38 ( SB-203580 ) , it was also demonstrated that both ERK1/2 and p38 pathways play key roles in the production of IL-6 as well as in ICAM-1 , VCAM-1 and E-selectin expression by Hib porin . Positive_regulation MAP2K6 RAF1 22826437 2670728 Furthermore , kinase activating mutants also *required* heterodimerization to enhance [MEK/ERK] activation . Positive_regulation MAP2K6 RAF1 7623807 316028 The serine/threonine kinase functions downstream from Ras to *activate* [mitogen activated protein kinase kinase] , but the mechanisms of Raf-1 activation are incompletely understood . Positive_regulation MAP2K6 RAF1 8413257 233816 To determine whether or not directly *activates* [MEK] , we developed an in vitro assay with purified recombinant proteins . Positive_regulation MAP2K6 RAF1 8413257 233830 We conclude that MEK is a direct substrate of Raf-1 and that the *activation* of [MEK] by is due to phosphorylation by Raf-1 , which is sufficient for MEK activation . Positive_regulation MAP2K6 RAF1 8808705 382937 phosphorylates and *activates* MAPK/ERK kinase [Mek] ) , thus initiating the Mek -- > MAP kinase cascade , which ultimately results in the phosphorylation and activation of transcription factors by MAP kinase . Positive_regulation MAP2K6 RAF1 9727031 529898 In addition , mitotic activation of does not *lead* to stimulation of the [mitogen activated protein kinase kinase] ( MAPKK or MEK ) and the extracellular signal regulated protein kinase ( ERK ) . Positive_regulation MAP2K6 RAF1 9826444 550616 *activates* the dual-specific kinase [MEK] , which in turn activates ERK . Positive_regulation MAP2K6 RALGDS 10866657 706018 Both Raf- and mediated induction *required* the activation of [mitogen activated protein kinase kinase] ( MEK ) . Positive_regulation MAP2K6 RAPGEF1 17825818 1810381 We hypothesize that *triggers* PP2A activation and binding to [MEK] and ERK at the subcortical actin cytoskeleton , thus favouring ERK dephosphorylation . Positive_regulation MAP2K6 RBM5 17521393 1772959 Pretreatment with N-acetyl-L-cysteine reduced , in a dose dependent manner , M. tuberculosis induced *activation* of [mitogen activated protein kinase kinase] 3/6 and interleukin-6 production in THP-1 cells . Positive_regulation MAP2K6 RHO 18255094 1877273 Thus , two distinct pathways involving the [EGFR/pp60(c-src)/MEK-ERK] pathway and dependent SMAD2 *activation* are required for TGF-beta1 induced PAI-1 expression in VSMC . Positive_regulation MAP2K6 ROCK1 18255094 1877274 Thus , two distinct pathways involving the [EGFR/pp60(c-src)/MEK-ERK] pathway and dependent SMAD2 *activation* are required for TGF-beta1 induced PAI-1 expression in VSMC . Positive_regulation MAP2K6 ROCK2 18255094 1877275 Thus , two distinct pathways involving the [EGFR/pp60(c-src)/MEK-ERK] pathway and dependent SMAD2 *activation* are required for TGF-beta1 induced PAI-1 expression in VSMC . Positive_regulation MAP2K6 RRM1 23922955 2826418 Furthermore , inhibition of by siRNA significantly *reduced* the dNTP pool , Ras/Raf and MMP-9 activities and the levels of [p-MEK] , p-ERK and NF-?B , resulting in growth retardation and reduced invasion in AGS and NCI-N87 cells . Positive_regulation MAP2K6 SCT 7611406 312071 In addition to CCK , bombesin and carbachol , but not or vasoactive intestinal peptide , *enhanced* [MEK] activity . Positive_regulation MAP2K6 SERPINE1 11719557 883715 TGF-beta1 induced gene expression *requires* [MEK] activity and cell-to-substrate adhesion . Positive_regulation MAP2K6 SERPINE1 11719557 883734 mRNA synthesis in response to substrate attachment , like TGF-beta1 mediated induction in adherent cultures , also *required* [MEK] activity as fibronectin stimulated PAI-1 expression was effectively attenuated by the MEK inhibitor PD98059 . Positive_regulation MAP2K6 SET 15703833 1372703 By contrast , knocking down I-2PP2A/SET by siRNA resulted in enhancement of ERK and MEK activations , suggesting that negatively *regulates* [MEK/ERK] . Positive_regulation MAP2K6 SETD2 22771629 2639539 Notoginsenoside Ft1 promotes angiogenesis via *mediated* VEGF secretion and the regulation of PI3K/AKT and [Raf/MEK/ERK] signaling pathways . Positive_regulation MAP2K6 SH2B1 20868529 2331931 Overexpressing the adaptor protein *enhanced* H2O2 induced PI3K-AKT and [MEK-ERK1/2] signaling , reduced nucleus localized FoxOs and the expression of a pro-apoptotic gene , FasL . Positive_regulation MAP2K6 SH2B1 24260264 2869575 Our data indicate that overexpressing *enhances* BDNF induced [MEK-ERK1/2] , and PI3K-AKT signaling pathways . Positive_regulation MAP2K6 SHC1 8033892 264160 We found that the expression of exogenous proteins *results* in an increased basal [MEK] ( MAPK/ERK activating kinase ) activity . Positive_regulation MAP2K6 SKP1 14592835 1209499 Western blot analyses revealed that was *required* for phosphorylation of [MEK] and p44MAPK in this setting , and quantitative polymerase chain reaction demonstrated a significant increase in gamma-globin mRNA . Positive_regulation MAP2K6 SKP1 22086674 2605278 Signaling analysis with immunoblots revealed that in human melanocytes or human melanoma cells treated with WSE , there was a marked deficiency in *stimulated* phosphorylation of ERK , MITF and CREB , but not of Raf-1 and [MEK] . Positive_regulation MAP2K6 SLC4A2 21143204 2425185 We also found that could *induce* the phosphorylation of p38 MAPK ( mitogen activated protein kinase ) , ERK1/2 ( extracellular-signal regulated kinase 1/2 ) , [MEK] ( MAPK/ERK kinase ) and JNK ( c-Jun N-terminal kinase ) , whereas it failed to induce phosphorylation of JAK2 ( Janus kinase 2 ) and STAT1 . Positive_regulation MAP2K6 SMAD7 12589052 1059834 Transforming growth factor-beta1 ( TGF-beta ) -induced apoptosis of prostate cancer cells involves dependent *activation* of p38 by TGF-beta activated kinase 1 and [mitogen activated protein kinase kinase] 3 . Positive_regulation MAP2K6 SOCS1 15707970 1372933 Additionally , *augmented* [MEK] phosphorylation and reduced Akt phosphorylation induced by IGF-I . Positive_regulation MAP2K6 SORT1 22061968 2547674 Rac1b regulates *stimulated* [Mek-Erk] signaling , directing marrow isolated adult multilineage inducible ( MIAMI ) cells toward an early neuronal phenotype . Positive_regulation MAP2K6 SOS1 11230180 789125 PTEN *inhibits* insulin stimulated [MEK/MAPK] activation and cell growth by blocking IRS-1 phosphorylation and complex formation in a breast cancer model . Positive_regulation MAP2K6 SOS2 11230180 789126 PTEN *inhibits* insulin stimulated [MEK/MAPK] activation and cell growth by blocking IRS-1 phosphorylation and complex formation in a breast cancer model . Positive_regulation MAP2K6 SP1 22609358 2609764 Treatment with U0126 , an [MEK] *inhibitor* , or Mithramycin A , an inhibitor , significantly attenuated promoter activity . Positive_regulation MAP2K6 SPP1 19475568 2107637 stimulation *increased* the phosphorylation of focal adhesion kinase ( FAK ) , [MEK] and extracellular signal regulated kinase ( ERK ) . Positive_regulation MAP2K6 SRC 11304531 826857 The MKK3 and [MKK6] activations by Galpha ( q ) , but not by Gbetagamma , were *dependent* on phospholipase C and . Positive_regulation MAP2K6 SRC 18452714 1926925 Moreover , thrombin stimulated activation of NF-kappaB , AP-1 , and COX-2 promoter activity was blocked by the inhibitors of c-Src , PKC , EGFR , MEK1/2 , AP-1 and NF-kappaB , suggesting that thrombin induces COX-2 promoter activity mediated through PKC ( delta ) *dependent* EGFR transactivation , [MEK-ERK1/2] , AP-1 , and NF-kappaB . Positive_regulation MAP2K6 SRC 9234720 445421 Although neither constitutively activated MEK ( MEK-2E ) nor was sufficient individually to differentiate the H19-7 cells , coexpression of constitutively activated [MEK] and v-Src *induced* neurite outgrowth . Positive_regulation MAP2K6 SRP14 11292597 800924 These results suggest that in the rat , [MEK] inhibition of acid stimulated pancreatic secretion and secretin release *involves* suppression of activity release . Positive_regulation MAP2K6 SRP19 11292597 800925 These results suggest that in the rat , [MEK] inhibition of acid stimulated pancreatic secretion and secretin release *involves* suppression of activity release . Positive_regulation MAP2K6 SRP54 11292597 800926 These results suggest that in the rat , [MEK] inhibition of acid stimulated pancreatic secretion and secretin release *involves* suppression of activity release . Positive_regulation MAP2K6 SRP68 11292597 800927 These results suggest that in the rat , [MEK] inhibition of acid stimulated pancreatic secretion and secretin release *involves* suppression of activity release . Positive_regulation MAP2K6 SRP72 11292597 800928 These results suggest that in the rat , [MEK] inhibition of acid stimulated pancreatic secretion and secretin release *involves* suppression of activity release . Positive_regulation MAP2K6 SRP9 11292597 800929 These results suggest that in the rat , [MEK] inhibition of acid stimulated pancreatic secretion and secretin release *involves* suppression of activity release . Positive_regulation MAP2K6 SRSF1 23843040 2854334 [B-Raf-MEK-ERK] *activation* by contributes to transformation as pharmacological inhibition of MEK1 inhibits SRSF1 mediated transformation . Positive_regulation MAP2K6 STAT1 21143204 2425186 We also found that AE2 could *induce* the phosphorylation of p38 MAPK ( mitogen activated protein kinase ) , ERK1/2 ( extracellular-signal regulated kinase 1/2 ) , [MEK] ( MAPK/ERK kinase ) and JNK ( c-Jun N-terminal kinase ) , whereas it failed to induce phosphorylation of JAK2 ( Janus kinase 2 ) and . Positive_regulation MAP2K6 STAT3 15378007 1323961 Our results showed that [mitogen activated protein kinase kinase] 5 ( MEK5 ) was markedly *induced* ( more than 22-fold increase , P < 0.001 ) by expression . Positive_regulation MAP2K6 STAT5A 10951574 723771 Inhibition of [MEK] activation completely abrogated OSM and IL-6 *induced* p27kip1 accumulation , while expression of dominant negative decreased the OSM and IL-6 mediated inhibition of DNA-synthesis and partially inhibited p27kip1 accumulation . Positive_regulation MAP2K6 STK10 10924861 718622 Genistein , a tyrosine kinase inhibitor , H7 , a inhibitor , and PD 98059 , a [MEK] *inhibitor* , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation MAP2K6 STK10 7623807 316013 The Raf-1 functions downstream from Ras to *activate* [mitogen activated protein kinase kinase] , but the mechanisms of Raf-1 activation are incompletely understood . Positive_regulation MAP2K6 STK11 10924861 718623 Genistein , a tyrosine kinase inhibitor , H7 , a inhibitor , and PD 98059 , a [MEK] *inhibitor* , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation MAP2K6 STK11 7623807 316014 The Raf-1 functions downstream from Ras to *activate* [mitogen activated protein kinase kinase] , but the mechanisms of Raf-1 activation are incompletely understood . Positive_regulation MAP2K6 STK16 10924861 718624 Genistein , a tyrosine kinase inhibitor , H7 , a inhibitor , and PD 98059 , a [MEK] *inhibitor* , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation MAP2K6 STK16 7623807 316015 The Raf-1 functions downstream from Ras to *activate* [mitogen activated protein kinase kinase] , but the mechanisms of Raf-1 activation are incompletely understood . Positive_regulation MAP2K6 STK19 10924861 718625 Genistein , a tyrosine kinase inhibitor , H7 , a inhibitor , and PD 98059 , a [MEK] *inhibitor* , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation MAP2K6 STK19 7623807 316016 The Raf-1 functions downstream from Ras to *activate* [mitogen activated protein kinase kinase] , but the mechanisms of Raf-1 activation are incompletely understood . Positive_regulation MAP2K6 STK24 10924861 718626 Genistein , a tyrosine kinase inhibitor , H7 , a inhibitor , and PD 98059 , a [MEK] *inhibitor* , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation MAP2K6 STK24 7623807 316017 The Raf-1 functions downstream from Ras to *activate* [mitogen activated protein kinase kinase] , but the mechanisms of Raf-1 activation are incompletely understood . Positive_regulation MAP2K6 STK25 10924861 718627 Genistein , a tyrosine kinase inhibitor , H7 , a inhibitor , and PD 98059 , a [MEK] *inhibitor* , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation MAP2K6 STK25 7623807 316018 The Raf-1 functions downstream from Ras to *activate* [mitogen activated protein kinase kinase] , but the mechanisms of Raf-1 activation are incompletely understood . Positive_regulation MAP2K6 STK3 10924861 718628 Genistein , a tyrosine kinase inhibitor , H7 , a inhibitor , and PD 98059 , a [MEK] *inhibitor* , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation MAP2K6 STK3 7623807 316019 The Raf-1 functions downstream from Ras to *activate* [mitogen activated protein kinase kinase] , but the mechanisms of Raf-1 activation are incompletely understood . Positive_regulation MAP2K6 STK31 10924861 718629 Genistein , a tyrosine kinase inhibitor , H7 , a inhibitor , and PD 98059 , a [MEK] *inhibitor* , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation MAP2K6 STK31 7623807 316020 The Raf-1 functions downstream from Ras to *activate* [mitogen activated protein kinase kinase] , but the mechanisms of Raf-1 activation are incompletely understood . Positive_regulation MAP2K6 STK33 10924861 718631 Genistein , a tyrosine kinase inhibitor , H7 , a inhibitor , and PD 98059 , a [MEK] *inhibitor* , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation MAP2K6 STK33 7623807 316022 The Raf-1 functions downstream from Ras to *activate* [mitogen activated protein kinase kinase] , but the mechanisms of Raf-1 activation are incompletely understood . Positive_regulation MAP2K6 STK35 10924861 718632 Genistein , a tyrosine kinase inhibitor , H7 , a inhibitor , and PD 98059 , a [MEK] *inhibitor* , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation MAP2K6 STK35 7623807 316023 The Raf-1 functions downstream from Ras to *activate* [mitogen activated protein kinase kinase] , but the mechanisms of Raf-1 activation are incompletely understood . Positive_regulation MAP2K6 STK36 10924861 718633 Genistein , a tyrosine kinase inhibitor , H7 , a inhibitor , and PD 98059 , a [MEK] *inhibitor* , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation MAP2K6 STK36 7623807 316024 The Raf-1 functions downstream from Ras to *activate* [mitogen activated protein kinase kinase] , but the mechanisms of Raf-1 activation are incompletely understood . Positive_regulation MAP2K6 STK38 10924861 718635 Genistein , a tyrosine kinase inhibitor , H7 , a inhibitor , and PD 98059 , a [MEK] *inhibitor* , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation MAP2K6 STK38 7623807 316026 The Raf-1 functions downstream from Ras to *activate* [mitogen activated protein kinase kinase] , but the mechanisms of Raf-1 activation are incompletely understood . Positive_regulation MAP2K6 STK39 10924861 718634 Genistein , a tyrosine kinase inhibitor , H7 , a inhibitor , and PD 98059 , a [MEK] *inhibitor* , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation MAP2K6 STK39 7623807 316025 The Raf-1 functions downstream from Ras to *activate* [mitogen activated protein kinase kinase] , but the mechanisms of Raf-1 activation are incompletely understood . Positive_regulation MAP2K6 STK4 10924861 718630 Genistein , a tyrosine kinase inhibitor , H7 , a inhibitor , and PD 98059 , a [MEK] *inhibitor* , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation MAP2K6 STK4 7623807 316021 The Raf-1 functions downstream from Ras to *activate* [mitogen activated protein kinase kinase] , but the mechanisms of Raf-1 activation are incompletely understood . Positive_regulation MAP2K6 STK4 9545236 498421 *activates* [MKK6] , p38 MAPK , MKK7 and SAPK in co-transfection assays , suggesting that Mst1 may activate these pathways . Positive_regulation MAP2K6 STK40 10924861 718636 Genistein , a tyrosine kinase inhibitor , H7 , a inhibitor , and PD 98059 , a [MEK] *inhibitor* , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation MAP2K6 STK40 7623807 316027 The Raf-1 functions downstream from Ras to *activate* [mitogen activated protein kinase kinase] , but the mechanisms of Raf-1 activation are incompletely understood . Positive_regulation MAP2K6 SYK 9720763 528558 We report that inhibition of PI3K by wortmannin or an inhibitory p85 construct , p85deltaiSH2 , reduced the TCR induced *dependent* activation of Erk2 , as well as the appearance of phospho-Erk and [phospho-Mek] . Positive_regulation MAP2K6 TAB1 10504490 648995 *stimulated* [MKK6] and p38K activity and inhibited the percentage of the S and G2/M phases . Positive_regulation MAP2K6 TAOK2 11279118 811818 Cotransfection experiments suggested that selectively *activates* MEK3 and [MEK6] but not MEKs 1 , 4 , or 7 . Positive_regulation MAP2K6 TAOK2 9786855 540901 *activated* MEK3 but not MEK4 or [MEK6] in transfected cells . Positive_regulation MAP2K6 TCF12 19248765 2050947 We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a [MEK/ERK] independent *activation* of signaling . Positive_regulation MAP2K6 TCF15 19248765 2050948 We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a [MEK/ERK] independent *activation* of signaling . Positive_regulation MAP2K6 TCF19 19248765 2050949 We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a [MEK/ERK] independent *activation* of signaling . Positive_regulation MAP2K6 TCF20 19248765 2050950 We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a [MEK/ERK] independent *activation* of signaling . Positive_regulation MAP2K6 TCF21 19248765 2050951 We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a [MEK/ERK] independent *activation* of signaling . Positive_regulation MAP2K6 TCF23 19248765 2050955 We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a [MEK/ERK] independent *activation* of signaling . Positive_regulation MAP2K6 TCF24 19248765 2050957 We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a [MEK/ERK] independent *activation* of signaling . Positive_regulation MAP2K6 TCF25 19248765 2050956 We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a [MEK/ERK] independent *activation* of signaling . Positive_regulation MAP2K6 TCF3 19248765 2050952 We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a [MEK/ERK] independent *activation* of signaling . Positive_regulation MAP2K6 TCF4 19248765 2050953 We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a [MEK/ERK] independent *activation* of signaling . Positive_regulation MAP2K6 TCF7 19248765 2050954 We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a [MEK/ERK] independent *activation* of signaling . Positive_regulation MAP2K6 TGFA 19823173 2187243 Rho/ROCK and [MEK/ERK] *activation* by induces articular cartilage degradation . Positive_regulation MAP2K6 TGFB1 11719557 883714 induced PAI-1 gene expression *requires* [MEK] activity and cell-to-substrate adhesion . Positive_regulation MAP2K6 TGFB1 19343212 2057365 Specifically , [MEK-ERK] signaling was dose-dependently induced in *response* to in immortalized cells in vitro and in the A. stephensi midgut epithelium in vivo . Positive_regulation MAP2K6 TGFB1 9038360 415495 *induces* activation of Ras , Raf-1 , [MEK] and MAPK in rat hepatic stellate cells . Positive_regulation MAP2K6 TGFB1 9038360 415523 In this paper we show that in cultured hepatic stellate cells *induces* activation of Ras , Raf-1 , [MEK] and MAPK p42 and p44 . Positive_regulation MAP2K6 TGFB2 7957934 278138 In addition , an increased de-novo synthesis of [MAP kinase kinase (MEK)] , the upstream activator of MAP kinase , is observed in *response* to stimulation . Positive_regulation MAP2K6 TGFBR1 17072348 1716609 Induction of MMP-9 by signaling *requires* [MEK-ERK] but not JNK , p38 MAPK or Smad4 . Positive_regulation MAP2K6 TIE1 12890486 1117317 Localization of and phospholipase D in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Positive_regulation MAP2K6 TIMP2 19551841 2185586 binding with cellular MT1-MMP *stimulates* invasion promoting [MEK/ERK] signaling in cancer cells . Positive_regulation MAP2K6 TLN1 21044336 2349280 Our recent studies suggest that inhibits the Ras-ERK MAPK pathway post Ras prenylation and prior to [MEK] *activation* . Positive_regulation MAP2K6 TLR4 16879219 1593866 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by [MEK/ERK] signaling and NFkappaB activation and that membrane bound CD14 and are *involved* in this mechanism . Positive_regulation MAP2K6 TLR4 22189943 2568733 In summary , UA after IRI mediates the acetylation and release of HMGB1 from endothelial cells by mechanisms that involve calcium mobilization , the [MEK/Erk] pathway , and *activation* of . Positive_regulation MAP2K6 TLR5 15069060 1251603 Thus , in non transformed human colonocytes , [MEK] *activation* following engagement is a key modulator for NFkappaB independent , IL-8 and MIP3alpha expression . Positive_regulation MAP2K6 TNF 10075082 594857 Beta-lapachone also abolished induced *activation* of AP-1 , c-Jun N-terminal kinase , and [mitogen activated protein kinase kinase] ( MAPKK or MEK ) . Positive_regulation MAP2K6 TNF 10439045 635254 gamma-GCS also abolished the activation of AP-1 induced by TNF and inhibited induced *activation* of JNK and [mitogen activated protein kinase kinase] . Positive_regulation MAP2K6 TNF 10586080 571816 Silymarin also inhibited the *induced* activation of [mitogen activated protein kinase kinase] and c-Jun N-terminal kinase and abrogated TNF induced cytotoxicity and caspase activation . Positive_regulation MAP2K6 TNF 10788437 688687 hCG abrogated the *induced* activation of [mitogen activated protein kinase kinase] and c-Jun N-terminal kinase required for NF-kappaB and AP-1 , respectively . Positive_regulation MAP2K6 TNF 10843709 700189 Resveratrol also inhibited the *induced* activation of [mitogen activated protein kinase kinase] and c-Jun N-terminal kinase and abrogated TNF induced cytotoxicity and caspase activation . Positive_regulation MAP2K6 TNF 11149911 780461 mediated *activation* of [MEK/ERK] and EGR-1 can be blocked by adenoviral expression of a dominant negative mutant of IKK2 , whereas the VEGF signaling pathway is unaffected . Positive_regulation MAP2K6 TNF 11156586 780630 To clarify these issues , we examined the effect of NAC on induced *activation* of p38 MAP kinase , MAP kinase kinase (MKK) 3 and [MKK6] which are upstream regulators of p38 MAP kinase , and p38 MAP kinase mediated IL-8 production . Positive_regulation MAP2K6 TNF 16452391 1547916 The Syk inhibitor also decreased *induced* [mitogen activated protein kinase kinase] ( MKK) 4 phosphorylation but not MKK3 and MKK6 phosphorylation , which is consistent with its selective sparing of p38 . Positive_regulation MAP2K6 TNF 19144181 2079126 Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by *induced* [MEK/ERK] signalling . Positive_regulation MAP2K6 TNF 19144181 2079134 *activates* [mitogen activated kinase kinase (MEK)/extracellular] regulated kinase (ERK) in chondrocytes ; Positive_regulation MAP2K6 TNF 19628074 2112822 and/or TGF-alpha stimulation *increased* [phospho-MEK] and phospho-ERK in cells transfected with TNFR1 siRNA . Positive_regulation MAP2K6 TNF 21320357 2393853 The effects of IL-1ß and on EPCR shedding in DU-145 cells are *mediated* by [MEK/ERK] 1/2 , JNK , and p38 MAPK signalling cascades . Positive_regulation MAP2K6 TNF 24151609 2859760 In our study , we found that a treatments *induce* [MEK] and AKT phosphorylation . Positive_regulation MAP2K6 TNF 8900184 393468 *Activation* of [mitogen activated protein kinase kinase] 6 by osmotic shock , , and H2O2 . Positive_regulation MAP2K6 TNF 8900184 393470 In addition , [MAPKK6] was *activated* strongly by , H2O2 , and okadaic acid and moderately by cycloheximide in KB cells . Positive_regulation MAP2K6 TNF 9582369 504231 In addition , Mn-SOD blocked the mediated *activation* of activated protein-1 , stress activated c-Jun protein kinase , and [mitogen activated protein kinase kinase] . Positive_regulation MAP2K6 TNFRSF11B 24126801 2858894 increased chondrocyte proliferation with maximal effect at 10 ng/ml , and *induced* the phosphorylation of [MEK] and ERK but not P38MAPK or JNK . Positive_regulation MAP2K6 TNFSF11 14672351 1178464 Assays for NF-kappaB nuclear translocation , NF-kappaB reporter gene activity , protein kinase activity , and Western blotting were used to examine the effects of TPA on *induced* NF-kappaB , c-Jun N-terminal kinase (JNK) , and [MEK/ERK] and p38 signal transduction pathways . Positive_regulation MAP2K6 TNFSF11 20506523 2307970 Stimulation of cells with *increased* the phosphorylation of [MEK] and extracellular signal regulating kinase ( ERK ) . Positive_regulation MAP2K6 TNFSF11 21328467 2394128 Stimulation of cells with *increased* the phosphorylation of [MEK] and extracellular signal regulating kinase ( ERK ) . Positive_regulation MAP2K6 TP53 20223820 2254395 Mutant *induced* up-regulation of [mitogen activated protein kinase kinase] 3 contributes to gain of function . Positive_regulation MAP2K6 TP53 22730327 2639106 We report here that delayed cell cycle progression , Ser-33 phosphorylation , and nuclear accumulation from SEPW1 depletion *require* [mitogen activated protein kinase kinase] 4 ( MKK4 ) . Positive_regulation MAP2K6 TP53 9765203 537543 Constitutive activation of [MEK] ( a component of the MAPK cascade ) *induces* both and p16 , and is required for Ras induced senescence of normal human fibroblasts . Positive_regulation MAP2K6 TPO 16449323 1521745 Inhibition of *induced* [MEK] or mTOR activity induces opposite effects on the ploidy of human differentiating megakaryocytes . Positive_regulation MAP2K6 TPO 9990315 560310 did not activate the mitogen activated protein kinase/ERK kinases , MEK1 and MEK2 , but activated Raf-1 and directly *augmented* the PKC mediated [MEK] activation , suggesting that TPO primarily potentiates the ERK pathway through regulating MEKs or upstream steps of MEKs including Raf-1 . Positive_regulation MAP2K6 TYR 24158441 2879102 in the kinase domain of the murine kinase suppressor of RAS 1 *regulates* binding and activation of the [mitogen activated protein kinase kinase] . Positive_regulation MAP2K6 UCP2 22348126 2561086 Further , *increased* the expression of cell cycle genes and protein levels of phospho-AKT , PKC and [MEK] after ischemia . Positive_regulation MAP2K6 VEGFA 10327068 612912 On the other hand , PKC-specific inhibitors severely reduced *dependent* phosphorylation of [MEK] , activation of MAP kinase and subsequent DNA synthesis . Positive_regulation MAP2K6 VEGFA 11171046 783697 PKC inhibitors blocked *induced* activation of ERK , [MEK] ( mitogen activated protein kinase kinase ) and the cytosolic phospholipase A(2) , but had little effect on ERK activation induced by basic fibroblast growth factor . Positive_regulation MAP2K6 VEGFA 14704231 1225428 Localization of VEGFR-2 and PLD2 in endothelial caveolae is involved in *induced* phosphorylation of [MEK] and ERK . Positive_regulation MAP2K6 VEGFA 19374835 2065485 IGFBP7 treatment suppressed *induced* tube formation , proliferation , and the phosphorylation of [mitogen activated protein kinase kinase] ( MEK ) and extracellular signal regulated kinase ( ERK ) 1/2 in HUVECs . Positive_regulation MAP2K6 VEGFA 22707147 2633938 Moreover , ( 165 ) *induced* phosphorylation of VEGFR-2 , PLC-?1 , PKC-a , [MEK] , and p44/42 MAPK ( ERK1/2 ) in a time dependent manner . Positive_regulation MAP2K6 VIP 7611406 312072 In addition to CCK , bombesin and carbachol , but not secretin or , *enhanced* [MEK] activity . Positive_regulation MAP2K6 WDR61 10606930 655868 The results showed that TNF alpha , IL-1 alpha and *induced* serine phosphorylation of MKK3 and [MKK6] , and p38 MAP kinase activation in BECs . Positive_regulation MAP2K6 WISP1 21453685 2422094 stimulation *increased* the phosphorylation of focal adhesion kinase ( FAK ) , [MEK] and extracellular signal regulated kinase ( ERK ) . Positive_regulation MAP2K6 WISP3 21391218 2521348 stimulation *increased* the phosphorylation of focal adhesion kinase ( FAK ) , [MEK] , and extracellular signal regulated kinase ( ERK ) . Positive_regulation MAP2K6 XIAP 20236757 2272935 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2 , Bcl-xL and ) , as well as *activation* of [Ras/MEK/ERK] and PI3K/Akt signaling . Positive_regulation MAP2K6 XIAP 21742513 2484271 Meanwhile , the further study demonstrates that the chemoresistance caused by IL-8 is associated with increased expression of both multidrug resistance related genes ( MDR1 ) and apoptosis inhibitory proteins ( Bcl-2 , Bcl-xL , and ) , as well as *activation* of PI3K/Akt and [Ras/MEK/ERK] signaling . Positive_regulation MAP2K6 YWHAB 8808705 382936 phosphorylates and *activates* MAPK/ERK kinase [Mek] ) , thus initiating the Mek -- > MAP kinase cascade , which ultimately results in the phosphorylation and activation of transcription factors by MAP kinase . Positive_regulation MAP2K6 ZNF445 16368201 1526455 Furthermore , we found that expression of can *increase* p42/44 MAPK , [MEK] and Raf-1 phosphorylation . Positive_regulation MAP2K7 ANGPT1 12890486 1117330 Localization of Tie2 and phospholipase D in endothelial caveolae is involved in *induced* [MEK/ERK] phosphorylation and migration in endothelial cells . Positive_regulation MAP2K7 ANGPT1 12890486 1117448 Ang1 induced MEK/ERK activation was abrogated when PLD was inhibited , suggesting that PLD mediates *induced* [MEK/ERK] activation . Positive_regulation MAP2K7 CCND1 22579115 2609559 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated and Cyclin B1 proteins as well as *activation* of PI3K/Akt and [Raf/MEK/ERK] , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation MAP2K7 CD14 16879219 1593844 Lipopolysaccharide induced decreased protein S expression in liver cells is mediated by [MEK/ERK] signaling and NFkappaB *activation* : involvement of membrane bound and toll-like receptor-4 . Positive_regulation MAP2K7 CD14 16879219 1593869 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by [MEK/ERK] signaling and NFkappaB activation and that membrane bound and TLR-4 are *involved* in this mechanism . Positive_regulation MAP2K7 CLU 15857407 1400250 The [mitogen activated protein kinase kinase] and protein kinase C inhibitors PD98059 and H7 inhibited mediated *induction* of reactive nitrogen intermediate secretion from cultured microglia . Positive_regulation MAP2K7 CLU 19218870 2039556 Exogenous *stimulates* Ras dependent [Raf-1/mitogen activated protein kinase kinase] ( MEK ) /ERK activation . Positive_regulation MAP2K7 CTGF 15855807 1425624 TGF-beta1 induced connective tissue growth factor ( ) expression in human renal proximal tubule epithelial cells *requires* [Ras/MEK/ERK] and Smad signalling . Positive_regulation MAP2K7 EPHB2 10996792 733919 As in proliferating cells , activation during G0 *required* the MAPkinase kinase [MEK] and was partially dependent on cell adhesion . Positive_regulation MAP2K7 EPHB2 11304535 819986 However , cyclin E expression is ineffectual in rescuing these effects when ERK activation is blocked by treatment with PD98059 , a selective inhibitor of [MEK] *activation* of . Positive_regulation MAP2K7 EPHB2 12675684 1076710 In contrast , the *activation* of by constitutively active forms of [MAP kinase kinase (MEK)] was not inhibited , suggesting that the actions of SptP were mediated by Raf-1 . Positive_regulation MAP2K7 EPHB2 15304546 1322471 Furthermore , *activation* of by the coexpression of constitutively active [MAPKK/MEK] predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAP2K7 EPHB2 15843535 1398482 As in the classical pathway , BCR induced activation in the new , PI3K independent pathway *required* [MEK] and was reflected in c-Raf . Positive_regulation MAP2K7 EPHB2 15855657 1439598 Activation of ERK was attenuated by drugs that disassemble the actin cytoskeleton ( cytochalasin D , latrunculin B ) , and these compounds interfered with the *activation* of by [mitogen activated protein kinase kinase] ( MEK ) . Positive_regulation MAP2K7 EPHB2 17337598 1765830 A pharmacological inhibitor of MEK activity inhibits LPA stimulated WT Hic-5 cell migration and ERK phosphorylation , suggesting Hic-5 enhances migration via [MEK] *activation* of . Positive_regulation MAP2K7 EPHB2 18194435 1895325 Although [mitogen activated protein kinase kinase] ( MEK ) and extracellular signal regulated protein kinase ( ERK ) are activated by GW5074 , pharmacological inhibition of signaling by U0126 or PD98059 does not *reduce* neuroprotection suggesting that B-Raf signals through a non-canonical signaling pathway . Positive_regulation MAP2K7 EPHB2 22328534 2642864 PD98059 , [MEK] *inhibitor* , or U0126 , inhibitor , reduced SNU668 cell migration accompanying an increase in p-GSK-3a , ß-catenin and E-cadherin . Positive_regulation MAP2K7 EPHB2 22506069 2583982 Activations of [MEK] , ERK , and NF-?B pathways after CCL5 treatment were demonstrated , and CCL5 induced expression of integrin and migration activity was *inhibited* by the specific inhibitor and mutant of MEK , , and NF-?B cascades . Positive_regulation MAP2K7 EPHB2 22740332 2715451 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Positive_regulation MAP2K7 EPHB2 22785235 2691855 TRH induced CRE promoter was inhibited by mitogen activated protein kinase ( MEK ) inhibitor and was *increased* by overexpression of [MEK kinase (MEKK)] . Positive_regulation MAP2K7 EPHB2 22892241 2666347 However , unlike ( V600E ) Braf , pathway activation was mediated by both Craf and Braf , and ATP-competitive RAF inhibitors *induced* paradoxical [Mek/Erk] pathway activation . Positive_regulation MAP2K7 EPHB2 7838428 286303 The protein expression profiles were almost equivalent , but the MEK expression was slightly advanced , suggesting that the observed up-regulation of [MEK] was not *due* to that of . Positive_regulation MAP2K7 EPHB2 8226933 235478 Phosphorylation of [MEK] is also *stimulated* by . Positive_regulation MAP2K7 FAS 22509080 2584045 Compared with HepG2 cell group and RNAi group , apoptosis rate , the expression of and FasL proteins , and the *activation* of MLK3 , [MKK7] and JNKs were increased in the pcDNA3.1-X transfected group . Positive_regulation MAP2K7 ID1 14742319 1250772 induced [Raf/MEK] pathway *activation* is essential for its protective role against taxol induced apoptosis in nasopharyngeal carcinoma cells . Positive_regulation MAP2K7 IFI27 10951574 723776 Inhibition of [MEK] activation completely abrogated OSM and IL-6 *induced* p27kip1 accumulation , while expression of dominant negative STAT5 decreased the OSM and IL-6 mediated inhibition of DNA-synthesis and partially inhibited accumulation . Positive_regulation MAP2K7 IL1B 11179516 784778 We found that *induced* ERK phosphorylation , PD153035 and [MEK] inhibitor PD98059 blocked IL-1 beta induced ERK activity . Positive_regulation MAP2K7 IL1B 16043966 1459736 Western blot analysis demonstrated that *increased* the activation of phosphorylated [MEK] and p38 MAPK in GH3 cells . Positive_regulation MAP2K7 MAP2K6 11085935 750715 Similarly , *activation* of JNK by [Ad-MKK7D] and p38-MAPK by resulted in the increased expression of PGHS-2 . Positive_regulation MAP2K7 PLAU 17681345 1822242 These latter effects were mediated by *induced* activation of the mitogen activated protein kinase/extracellular signal regulated kinase ( [MEK] ) . Positive_regulation MAP2K7 PLAU 22155455 2542710 uPA downregulated PON1 gene expression via inactivation of peroxisome proliferator activated receptor-? ( PPAR? ) activity , and this effect was dependent on mediated [mitogen activated protein kinase kinase] *activation* . Positive_regulation MAP2K7 PLAU 22155455 2542732 Mechanistic studies showed that *enhanced* [mitogen activated protein kinase kinase-PPAR?] interaction , resulting in PPAR? nuclear export to the cytosol . Positive_regulation MAP2K7 STK39 10924861 718649 Genistein , a tyrosine kinase inhibitor , H7 , a inhibitor , and PD 98059 , a [MEK] *inhibitor* , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation MAP2K7 STK39 7623807 316041 The Raf-1 functions downstream from Ras to *activate* [mitogen activated protein kinase kinase] , but the mechanisms of Raf-1 activation are incompletely understood . Positive_regulation MAP2K7 TNF 10075082 594858 Beta-lapachone also abolished *induced* activation of AP-1 , c-Jun N-terminal kinase , and [mitogen activated protein kinase kinase] ( MAPKK or MEK ) . Positive_regulation MAP2K7 TNF 10439045 635255 gamma-GCS also abolished the activation of AP-1 induced by TNF and inhibited *induced* activation of JNK and [mitogen activated protein kinase kinase] . Positive_regulation MAP2K7 TNF 10586080 571817 Silymarin also inhibited the induced *activation* of [mitogen activated protein kinase kinase] and c-Jun N-terminal kinase and abrogated TNF induced cytotoxicity and caspase activation . Positive_regulation MAP2K7 TNF 10788437 688688 hCG abrogated the induced *activation* of [mitogen activated protein kinase kinase] and c-Jun N-terminal kinase required for NF-kappaB and AP-1 , respectively . Positive_regulation MAP2K7 TNF 10843709 700190 Resveratrol also inhibited the induced *activation* of [mitogen activated protein kinase kinase] and c-Jun N-terminal kinase and abrogated TNF induced cytotoxicity and caspase activation . Positive_regulation MAP2K7 TNF 11149911 780463 mediated *activation* of [MEK/ERK] and EGR-1 can be blocked by adenoviral expression of a dominant negative mutant of IKK2 , whereas the VEGF signaling pathway is unaffected . Positive_regulation MAP2K7 TNF 16452391 1547917 The Syk inhibitor also decreased *induced* [mitogen activated protein kinase kinase] ( MKK) 4 phosphorylation but not MKK3 and MKK6 phosphorylation , which is consistent with its selective sparing of p38 . Positive_regulation MAP2K7 TNF 18713996 1950849 , peptidoglycan ( PGN ) , and LPS stimulation *led* to higher and more prolonged [MKK7] phosphorylation compared with MKK4 in FLS . Positive_regulation MAP2K7 TNF 19144181 2079127 Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by *induced* [MEK/ERK] signalling . Positive_regulation MAP2K7 TNF 19144181 2079135 *activates* [mitogen activated kinase kinase (MEK)/extracellular] regulated kinase (ERK) in chondrocytes ; Positive_regulation MAP2K7 TNF 19628074 2112823 and/or TGF-alpha stimulation *increased* [phospho-MEK] and phospho-ERK in cells transfected with TNFR1 siRNA . Positive_regulation MAP2K7 TNF 21320357 2393855 The effects of IL-1ß and on EPCR shedding in DU-145 cells are *mediated* by [MEK/ERK] 1/2 , JNK , and p38 MAPK signalling cascades . Positive_regulation MAP2K7 TNF 24151609 2859761 In our study , we found that a treatments *induce* [MEK] and AKT phosphorylation . Positive_regulation MAP2K7 TNF 8900184 393469 *Activation* of [mitogen activated protein kinase kinase] 6 by osmotic shock , , and H2O2 . Positive_regulation MAP2K7 TNF 9384583 466380 [MKK7] is *activated* strongly by as well as by environmental stresses , whereas SEK1/MKK4 is not activated by TNFalpha . Positive_regulation MAP2K7 TNF 9582369 504232 In addition , Mn-SOD blocked the *mediated* activation of activated protein-1 , stress activated c-Jun protein kinase , and [mitogen activated protein kinase kinase] . Positive_regulation MAP3K1 IL1B 16881054 1613797 Transient transfection with MEK kinase 1 (MEKK1) or nuclear factor-kappa B (NF-kappaB) expression plasmids induced iNOS , and further *enhanced* the [MEKK1] response . Positive_regulation MAP3K1 TNF 10346818 616676 also *enhances* the binding of native TRAF2 to [MEKK1] and stimulates the kinase activity of the latter . Positive_regulation MAP3K1 TNF 11369754 834600 We also demonstrated that the *induced* [MEKK1] activation was defective in RIP-deficient Jurkat cells . Positive_regulation MAP3K1 TNF 11369754 834601 Taken together , our results suggest that RIP phosphorylates and activates MEKK1 and that RIP is involved in *induced* [MEKK1] activation . Positive_regulation MAP3K1 TNF 12600818 1085044 treatment *induced* both Ras and [MEKK1] activation . Positive_regulation MAP3K1 TNF 9177222 434132 Expression of activated [MEKK1] ( DeltaMEKK1 ) in MC/9 cells strongly stimulated JNK activity but only weakly stimulated p38 activity , and it *induced* a large activation of promoter regulated luciferase gene expression . Positive_regulation MAP3K1 TNF 9819420 547262 [MEKK1] is *activated* by and interleukin-1 and can potentiate the stimulatory effect of TNF-alpha on IKK and NF-kappaB activation . Positive_regulation MAP3K11 CTGF 23906792 2866077 The *induced* increase in [MLK3] phosphorylation was inhibited by RacN17 . Positive_regulation MAP3K11 EPHB2 16537381 1536581 We show that the activation of and the proliferation of human schwannoma cells bearing a loss-of-function mutation in the neurofibromatosis 2 (NF2) gene *require* [MLK3] . Positive_regulation MAP3K11 GRIK2 15308300 1284885 These results indicate that PSD-95 plays an important role in the formation of the . PSD-95 . MLK3 signaling module and [MLK3] and JNK3 *activation* in postischemic rat hippocampus . Positive_regulation MAP3K11 GRIK2 19477222 2097646 In our previous studies , Tat-GluR6-9c ( a glutamate receptor 6 C-terminus peptide fused the TAT protein transduction sequence ) not only inhibited the *activation* of [MLK3] ( mixed lineage kinase 3 ) and JNK ( c-Jun N-terminal kinase ) via the . PSD-95 ( postsynaptic density protein 95 ) . MLK3 signaling module but also diminished neuronal death induced by kainic acid or transient cerebral ischemia in rat hippocampus . Positive_regulation MAP3K11 GRIK2 20219637 2249321 The released GABA activates postsynaptic GABA ( A ) receptors , which suppress the ischemic depolarization and decrease the association of signaling module [Gluk2-PSD-95-MLK3] *induced* by the activation of postsynaptic receptors . Positive_regulation MAP3K11 IL1B 19586614 2122596 Here we report that both TNF and stimulation rapidly *activate* [MLK3] kinase activity . Positive_regulation MAP3K11 TNF 12504027 1026908 In addition , also *activates* [MLK3] and evidently leads to JNK activation in vivo . Positive_regulation MAP3K11 TNF 19586614 2122595 Here we report that both and interleukin-1 beta (IL-1 beta) stimulation rapidly *activate* [MLK3] kinase activity . Positive_regulation MAP3K11 TNF 19918265 2190009 TRAF2-MLK3 interaction is essential for *induced* [MLK3] activation . Positive_regulation MAP3K11 TNF 19918265 2190019 Hence , our data show that the direct interaction between TRAF2 and MLK3 is required for *induced* activation of [MLK3] and its downstream target , JNK . Positive_regulation MAP3K12 EPHB2 12388555 1020104 K252a and CEP1347 are neuroprotective compounds that inhibit [mixed-lineage kinase-3] and induce *activation* of Akt and . Positive_regulation MAP3K12 TGM2 14739943 1235045 *triggers* oligomerization and activation of [dual leucine zipper bearing kinase] in calphostin C-treated cells to facilitate apoptosis . Positive_regulation MAP3K13 EPHB2 24768141 2939522 Because mixed lineage kinase (MLK) and one of its downstream effectors ( extracellular signal regulated kinases [ ERK ] ) have previously been implicated in some aspects of prostate epithelial differentiation , we conducted further studies in which LNCaP cells were cotreated with dimethyl sulfoxide ( control ) , PD98059 ( inhibitor ) , or [MLK] *inhibitor* during transfection with Ad-SLFN12 for 72 h . Positive_regulation MAP3K14 EPHB2 9689078 522777 We have previously shown that mitogen activated protein kinase kinase 1 ( MEKK1 ) can *induce* both this site-specific phosphorylation of IkappaB alpha at Ser-32 and Ser-36 in vivo and the activity of a high molecular weight [IkappaB kinase complex] in vitro . Positive_regulation MAP3K14 IL1B 15550384 1360969 Iron mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha induced but not *induced* [IkappaB kinase complex/nuclear] factor-kappaB activation . Positive_regulation MAP3K14 TNF 12867425 1141847 A role for NF-kappaB essential modifier/IkappaB kinase-gamma ( NEMO/IKKgamma ) ubiquitination in the *activation* of the [IkappaB kinase complex] by . Positive_regulation MAP3K2 TNF 14978743 1213703 Bacterial lipopolysaccharide (LPS) and neither activate ERK5 nor *require* [MEKK2] for JNK activation , demonstrating specificity of MEKK2 in FGF-2 receptor signaling and control of cytokine gene expression . Positive_regulation MAP3K3 TNF 18206350 1870561 Expression of non phosphorylated TAK1 interferes with [MEKK3] phosphorylation and NF-kappaB reporter activity *induced* by transient MEKK3 expression or stimulation . Positive_regulation MAP3K5 CCND1 21187402 2378867 ASK1 overexpression induced the transcription of cyclin D1 , through AP-1 activation , and [ASK1] levels were *regulated* by , via the Rb-E2F pathway . Positive_regulation MAP3K5 CHI3L1 15015934 1251096 The suppressive effects of were dependent on phosphoinositide 3-kinase activity , and treatment of cells with HC-gp39 *resulted* in AKT mediated serine/threonine phosphorylation of [apoptosis signal regulating kinase 1] . Positive_regulation MAP3K5 EPHB2 10734135 678836 ASK1DeltaN induced neurite outgrowth was strongly inhibited by treatment with the p38 inhibitor SB203580 but not with the MEK inhibitors , suggesting that activation of p38 , rather than of , is *required* for the neurite inducing activity of [ASK1] in PC12 cells . Positive_regulation MAP3K5 EPHB2 15467832 1305799 The expression level and activation of MEK1/2 or showed no difference , but the kinase activity of [apoptosis signal regulating kinase 1] ( ASK1 ) , JNK , or p38 *increased* significantly compared with that in controls . Positive_regulation MAP3K5 FAS 11096076 780067 ligation *activated* [apoptosis signal regulating kinase 1] ( ASK1 ) and c-Jun N-terminal kinase ( JNK ; also known as stress activated protein kinase ( SAPK ) ) in Gln deprived cells but not in normal cells , suggesting that Gln might be involved in the activity control of ASK1 and JNK/SAPK . Positive_regulation MAP3K5 FAS 12132586 966898 In addition , core protein blocked the *mediated* activation of [apoptosis signal regulating kinase 1] ( ASK1 ) , a major upstream MAPKKK of p38 . Positive_regulation MAP3K5 FAS 9743501 532550 activation *induced* Daxx to interact with [ASK1] , which consequently relieved an inhibitory intramolecular interaction between the amino- and carboxyl-termini of ASK1 , activating its kinase activity . Positive_regulation MAP3K5 TNF 10523862 653806 A truncated derivative of TRAF2 , which inhibits SAPK activation by TNF , blocks *induced* [ASK1] activation . Positive_regulation MAP3K5 TNF 10688666 670139 Thus , *activation* of [ASK1] by requires the ROS mediated dissociation of Trx possibly followed by the binding of TRAF2 and consequent ASK1 homo-oligomerization . Positive_regulation MAP3K5 TNF 11285311 799846 Laminar flow inhibits *induced* [ASK1] activation by preventing dissociation of ASK1 from its inhibitor 14-3-3 . Positive_regulation MAP3K5 TNF 12556535 1071641 IGF-IR signaling inhibited ASK1 irrespective of *induced* [ASK1] activation and resulted in decreased ASK1 dependent JNK1 stimulation . Positive_regulation MAP3K5 TNF 12813014 1103088 Evidence now shows that the ASK1 interacting protein , AIP1 , plays an important role in *induced* [ASK1] activation by facilitating dissociation from its inhibitor . Positive_regulation MAP3K5 TNF 12813029 1103097 AIP1 mediates *induced* [ASK1] activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3 . Positive_regulation MAP3K5 TNF 12813029 1103107 Furthermore , *induced* [ASK1/JNK] activation is significantly blunted in cells where AIP1 is knocked down by RNA interference . Positive_regulation MAP3K5 TNF 12813029 1103108 These data suggest that AIP1 mediates induced [ASK1] *activation* by facilitating dissociation of inhibitor 14-3-3 from ASK1 , a novel mechanism by which TNF-alpha activates ASK1 . Positive_regulation MAP3K5 TNF 14720501 1197831 Ebselen inhibited *induced* TNF receptor associated factor 2 [(TRAF2)-ASK1] complex formation and phosphorylation of stress activated protein kinase ERK kinase 1 ( SEK1 ) , which is an upstream signaling molecule of JNK . Positive_regulation MAP3K5 TNF 15701637 1388709 We have recently identified ASK1 interacting protein ( AIP1 ) as novel signal transducer in *induced* [ASK1] activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3 . Positive_regulation MAP3K5 TNF 15701637 1388712 Our study suggests that TNFalpha induced desumoylation and cytoplasmic translocation of HIPK1 are critical in induced [ASK1-JNK/p38] *activation* . Positive_regulation MAP3K5 TNF 16195372 1462897 Wild-type induces TNFR2 and Etk and *activates* both [ASK1] and Etk but does not down-regulate TNFR1 . Positive_regulation MAP3K5 TNF 16407264 1527393 SOCS1 inhibits *induced* activation of [ASK1-JNK] inflammatory signaling by mediating ASK1 degradation . Positive_regulation MAP3K5 TNF 16407264 1527395 We have previously shown that [ASK1] undergoes ubiquitination and degradation in resting endothelial cells ( EC ) and that proinflammatory cytokine *induces* deubiquitination and stabilization , leading to ASK1 activation . Positive_regulation MAP3K5 TNF 16636664 1611884 Conversely , silencing of GSTP1-1 expression through RNA interference ( RNAi ) resulted in increase of *dependent* [TRAF2-ASK1] association followed by hyper-activation of ASK1 and JNK . Positive_regulation MAP3K5 TNF 16644673 1553120 significantly *activated* [ASK1] , increased serine phosphorylation of insulin receptor substrate (IRS)-1 , and decreased insulin stimulated tyrosine phosphorylation of IRS-1 and serine phosphorylation of Akt , and all of these effects were inhibited by overexpression of either UCP-1 or MnSOD . Positive_regulation MAP3K5 TNF 16644673 1553125 These results suggest that increases mitochondrial ROS and *activates* [ASK1] in Huh7 cells and that these TNF-alpha induced phenomena contribute , at least in part , to impaired insulin signaling . Positive_regulation MAP3K5 TNF 17258890 1725476 Otherwise , and FasL stimulation *led* to radical oxygen species ( ROS ) generation and [ASK1] ( Apoptosis-signal-regulating-kinase-1 ) activation . Positive_regulation MAP3K5 TNF 17389591 1735569 RIP1 mediated AIP1 phosphorylation at a 14-3-3 binding site is critical for *induced* [ASK1-JNK/p38] activation . Positive_regulation MAP3K5 TNF 17389591 1735577 Overexpression of AIP1-S604A blocks *induced* [ASK1-JNK] activation . Positive_regulation MAP3K5 TNF 17389591 1735594 Our results demonstrate that RIP1 mediated AIP1 phosphorylation at the 14-3-3 binding site Ser-604 is essential for *induced* TRAF2-RIP1-AIP1-ASK1 complex formation and for the activation of [ASK1-JNK/p38] apoptotic signaling . Positive_regulation MAP3K5 TNF 18219322 1876739 Furthermore , the wild-type form of SENP1 enhances , whereas the catalytic-inactive mutant form or siRNA of SENP1 blocks , *induced* desumoylation and cytoplasmic translocation of HIPK1 as well as TNF induced [ASK1-JNK] activation . Positive_regulation MAP3K5 TNF 18281285 1896427 We have previously shown that ASK1 interacting protein 1 (AIP1) transduces *induced* [ASK1-JNK] signaling . Positive_regulation MAP3K5 TNF 18292600 1891522 AIP1 recruits phosphatase PP2A to ASK1 in *induced* [ASK1-JNK] activation . Positive_regulation MAP3K5 TNF 18292600 1891549 Furthermore , *induced* association of PP2A with [ASK1] was diminished in AIP1-knockdown ECs , suggesting a critical role of AIP1 in recruiting PP2A to ASK1 . Positive_regulation MAP3K5 TNF 18292600 1891571 Taken together , our data support a critical role of PP2A-AIP1 complex in *induced* activation of [ASK1-JNK] apoptotic signaling . Positive_regulation MAP3K5 TNF 18852704 2021384 Furthermore , we present evidence that 6 activities were *essential* for ROS mediated [ASK1] activation by M. bovis BCG . Positive_regulation MAP3K5 TNF 19287004 2072957 SHP2 associated with [ASK1] in *response* to in EC . Positive_regulation MAP3K5 TNF 19788501 2168442 In ( WT ) C57BL/6 myocardium , *activated* both [ASK1] and Etk , and increased both apoptosis and cell cycle entry . Positive_regulation MAP3K5 TNF 19789334 2147756 However , K63 linked Daxx polyubiquitination is required for induced *activation* of [ASK1] . Positive_regulation MAP3K5 TNF 22711527 2670035 Stimulation of cells with *enhanced* [ASK1] , JNK , and p38 activation . Positive_regulation MAP3K5 TNF 24371084 2911652 Phosphorylated [ASK1] increased in wild-type mouse brains , and phosphorylated p38 and expression *increased* in corpus callosum cerebral endothelial cells after BCAS in wild-type mice but not in ASK1 ( -/- ) mice . Positive_regulation MAP3K5 TNF 9651337 515507 *induced* activation of [ASK1] was inhibited by antioxidants . Positive_regulation MAP3K5 TNF 9651337 515508 These results suggest that *induced* activation of [ASK1] is mediated by ROS . Positive_regulation MAP3K5 TNF 9651337 515509 or hydrogen peroxide treatment *increased* the dimeric form of [ASK1] , and pretreatment with N-acetylcysteine decreased it . Positive_regulation MAP3K5 TNF 9651337 515510 These results taken together suggest that *causes* [ASK1] activation via ROS mediated dimerization of ASK1 . Positive_regulation MAP3K5 TNF 9774977 540123 The [apoptosis signal regulating kinase 1] ( ASK1 ) is *activated* by and stimulates JNK activation . Positive_regulation MAP3K5 TNF 9774977 540124 A truncated derivative of TRAF2 , which inhibits JNK activation by TNF , blocks *induced* [ASK1] activation . Positive_regulation MAP3K7 EPHB2 23536866 2762747 Furthermore , our mechanistic studies indicated that NOR obviously suppressed the ubiquitination of TRAF6 , the accumulation of [TRAF6-TAK1] complexes and the *activation* of and p38 MAPK , and reduced the nuclear translocation of NF-?B-p65 and DNA binding activity of NF-?B . Positive_regulation MAP3K7 IL1B 15743758 1396788 Transforming growth factor (TGF)-beta , bone morphogenetic protein (BMP) , and *activate* [TGF-beta activated kinase 1 (TAK1)] , which lies upstream of the p38 MAPK , JNK , and NF-kappaB pathways . Positive_regulation MAP3K7 IL1B 15917296 1433614 transiently *induces* association between [TAK1] and the MAD homology 2 domain of SMAD3 , resulting in SMAD3 phosphorylation . Positive_regulation MAP3K7 IL1B 17559674 1792015 Quantitative PCR showed that [TAK1] deficiency significantly decreased *induced* MMP3 gene expression and IL-6 protein expression . Positive_regulation MAP3K7 IL1B 19232515 2050508 FBXW5 , an F-box family protein , was identified as a previously unknown component of the *induced* [TAK1 complex] . Positive_regulation MAP3K7 IL1B 19232515 2050517 Overexpression of FBXW5 inhibited *induced* activation of JNK/p38 MAPKs and NF-kappaB as well as phosphorylation of [TAK1] on Thr187 . Positive_regulation MAP3K7 RCAN1 19716405 2158167 also *stimulated* IL-1R mediated signaling pathways , [TAK1] activation , NF-kappaB transactivation , and IL-8 production , all downstream consequences of IL-1R activation . Positive_regulation MAP3K7 TLR7 21232528 2392261 Stimulation with LPS also triggered the modification ( phosphorylation and ubiquitination ) and eventually the proteasomal degradation of membrane associated interleukin (IL)-1 receptor associated serine/threonine kinase 1 ( IRAK-1 ) , an essential signaling component to mediated [TAK-1] *activation* . Positive_regulation MAP3K7 TLR7 24277938 2898494 Upon *stimulation* with ligands , S6K1 deficiency causes a marked increase in [TAK1] kinase activity that in turn induces a substantial enhancement of NF-?B dependent gene expression , indicating that S6K1 is negatively involved in the TLR signaling pathway by the inhibition of TAK1 activity . Positive_regulation MAP3K7 TNF 10187861 603061 Furthermore , activated endogenous TAK1 , and the kinase negative [TAK1] *acted* as a dominant negative inhibitor against tumor necrosis factor-alpha induced NF-kappaB activation . Positive_regulation MAP3K7 TNF 14633987 1170871 Cotransfection of siRNAs directed against both TAB2 and TAB3 inhibit both IL-1- and induced *activation* of [TAK1] and NF-kappaB . Positive_regulation MAP3K7 TNF 15590691 1368804 Immunoblotting with a novel phospho-TAK1 antibody revealed that significantly *induced* the phosphorylation of endogenous [TAK1] at Thr-187 , and subsequently the phosphorylated forms of TAK1 rapidly disappeared . Positive_regulation MAP3K7 TNF 15590691 1368822 Furthermore , SB203580 and p38alpha small interfering RNA enhanced *induced* Thr-187 phosphorylation as well as [TAK1] kinase activity , indicating that the phosphorylation is affected by p38alpha/TAB1/TAB2 mediated feedback control of TAK1 . Positive_regulation MAP3K7 TNF 15837794 1432560 We identified 518 genes that were regulated by TNF in both TAK1K63W expressing cells and control cells , 37 genes *induced* by only when [TAK1K63W] was present , and 48 TNF induced genes that were suppressed by TAK1K63W . Positive_regulation MAP3K7 TNF 16385569 1533419 Activation of endogenous [TAK1] , a mitogen activated protein kinase ( MAP3K ) regulating the JNK and p38 MAPK pathways , was *induced* rapidly by , and co-transfection of TAK1 with its activator protein TAB1 stimulated activation of JNK and p38 MAPKs , which led to activation of the transcription factor AP-1 . Positive_regulation MAP3K7 TNF 17110449 1732127 Recent studies indicate that induced IKK activation *requires* activation of [TAK1] , and we indeed found that celastrol inhibited the TAK1 induced NF-kappaB activation . Positive_regulation MAP3K7 TNF 17387141 1741649 Fisetin also inhibited *induced* [TAK1] and receptor interacting protein activation , events that lie upstream of IKK activation . Positive_regulation MAP3K7 TNF 17897957 1824017 *increased* the activity of transforming growth factor-beta activating kinase-1 ( [TAK1] ) . Positive_regulation MAP3K7 TNF 19393267 2094947 Cross interference with induced [TAK1] *activation* via EGFR mediated p38 phosphorylation of TAK1 binding protein 1 . Positive_regulation MAP3K7 TNF 19393267 2094955 The inducible phosphorylation of TAB1 interfered with a response of EGF treated cells to induced [TAK1] *activation* , which led to the reduction of NF-kappaB activation . Positive_regulation MAP3K7 TNF 19393267 2094958 Collectively , these results demonstrated that EGFR activation interfered with induced [TAK1] *activation* via p38 mediated phosphorylation of TAB1 . Positive_regulation MAP3K7 TNF 19410630 2089687 *augmented* the phosphorylation of [TAK1] . Positive_regulation MAP3K7 TNF 22525462 2602286 [TGF-ß activated kinase 1 (TAK1)] is *activated* by both TGF-ß1 and , activating both nuclear factor kappa-light-chain-enhancer of activated B cells and mitogen activated protein kinase signaling pathways . Positive_regulation MAP3K8 CST6 21182083 2373790 plus IFN-? *activated* the IKK complex to induce phosphorylation mediated degradation of p105 , the physiological partner and inhibitor of the MEK kinase , [tumor progression locus 2 (Tpl-2)] . Positive_regulation MAP3K8 IL1B 19808894 2187063 We show that the MAP3K8 called Tpl2 was expressed in adipocytes and that and TNF-alpha *activated* [Tpl2] and regulated its expression through an IKKbeta pathway . Positive_regulation MAP3K8 NEDD9 19754427 2153304 In these cells IL-1 does not activate IKKbeta or *induce* the phosphorylation of , and nor does the IKKbeta inhibitor PS1145 prevent the IL-1 induced activation of transfected [Tpl2] . Positive_regulation MAP3K8 NEDD9 22733995 2639208 *Activation* of [TPL-2/ERK] signaling by IKK induced proteolysis , therefore , induced a negative feedback loop to downregulate NF-?B dependent expression of the proinflammatory cytokine interleukin-12 (IL-12) . Positive_regulation MAP3K8 TLR7 15372110 1297799 We show here that [Cot/Tpl2] is also *activated* by other ligands . Positive_regulation MAP3K8 TLR7 24404585 2884103 Together , our finding shows that in addition to the *mediated* [TPL2] activation of ERK1/ERK2 , an additional pathway contributing to ERK1/ERK2 activation is triggered by infection of CF AECs : the EGFR signaling pathway . Positive_regulation MAP3K8 TNF 10072079 594381 Conversely , expression of kinase-deficient [Cot] inhibits CD3/CD28 but not *induction* of NF-kappaB . Positive_regulation MAP3K8 TNF 15833743 1418005 In addition , we show that the *activation* of [Tpl2] by depends on signals transduced by both TRAF2 and RIP1 . Positive_regulation MAP3K8 TNF 16291755 1510581 Here we showed that [Tpl2] *activation* by signals depends on the integrity of the Tpl2 interacting proteins RIP1 and TRAF2 , which are required for the engagement of the ERK mitogen activated protein kinase pathway . Positive_regulation MAP3K8 TNF 16291755 1510586 We also showed that [Tpl2] *activation* by depends on a tyrosine kinase activity that is detected in TNF-alpha stimulated cells . Positive_regulation MAP3K8 TNF 16806191 1580403 The protein kinase [COT/Tpl2] is *activated* by interleukin-1 (IL-1) , and lipopolysaccharide , and its activation by these agonists involves the IkappaB kinase beta (IKKbeta) catalysed phosphorylation of the p105 regulatory subunit . Positive_regulation MAP3K8 TNF 19808894 2187062 We show that the MAP3K8 called Tpl2 was expressed in adipocytes and that IL-1beta and *activated* [Tpl2] and regulated its expression through an IKKbeta pathway . Positive_regulation MAP4K1 ITGB2 23460610 2781863 Accordingly , CXCL1 mediated induction of high-affinity *required* [HPK1] , but macrophage antigen 1 (Mac-1) affinity regulation was independent of HPK1 . Positive_regulation MAP4K4 TNF 17500068 1761786 signaling decreases peroxisome proliferator activated receptor gamma and glucose transporter isoform 4 (GLUT4) expression in adipocytes , impairing insulin action , and this is *mediated* in part by the yeast Ste20 protein kinase ortholog [Map4k4] . Positive_regulation MAP4K4 TNF 17500068 1761787 Here we show that [Map4k4] expression is selectively *up-regulated* by , whereas the expression of the protein kinases JNK1/2 , ERK1/2 , p38 stress activated protein kinase , and mitogen activated protein kinase kinases 4/7 shows little or no response . Positive_regulation MAP4K4 TNF 22816003 2634916 Our findings suggest that Aah venom induces insulin resistance by mechanisms involving *dependent* [Map4k4] kinase activation in the adipose tissue . Positive_regulation MAP7 F2R 19081075 2003390 is *required* for [ensconsin] localization and directly phosphorylates it at conserved sites . Positive_regulation MAPK1 ADRB2 11018034 752785 induced p38 [MAPK] *activation* is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes . Positive_regulation MAPK1 ADRB2 12509508 1038732 beta-Arrestin 1 is required for internalization and [mitogen activated protein (MAP) kinase] *activation* by the . Positive_regulation MAPK1 ADRB2 19047375 2023479 Hematopoietic protein tyrosine phosphatase mediates *induced* regulation of p38 [mitogen activated protein kinase] in B lymphocytes . Positive_regulation MAPK1 ADRB2 9038193 415360 In the present work , we report that stimulation of the A2A-adenosine receptor and of the *activates* [mitogen activated protein kinase] ( MAP kinase ) in human endothelial cells based on the following criteria : adenosine analogues and beta-adrenergic agonists cause an ( i ) increase in tyrosine phosphorylation of the p42 isoform and to a lesser extent of the p44 isoform of MAP kinase and ( ii ) stimulate the phosphorylation of myelin basic protein by MAP kinase; (iii) this is accompanied by a redistribution of the enzyme to the perinuclear region . Positive_regulation MAPK1 ADRB2 9363896 462903 We show that in HEK293 cells , *stimulation* of [mitogen activated protein (MAP) kinase] by the is mediated by the betagamma subunits of pertussis-toxin-sensitive G proteins through a pathway involving the non-receptor tyrosine kinase c-Src and the G protein Ras . Positive_regulation MAPK1 ADRB2 9924018 588268 beta-Arrestin 1 mutants , impaired either in c-Src binding or in the ability to target receptors to clathrin coated pits , acted as dominant negative inhibitors of *mediated* activation of the MAP kinases Erk1 and [Erk2] . Positive_regulation MAPK1 ALOX5 11807011 903503 In contrast , stress induced product formation and translocation of <5-LO> , as well as *activation* of p38 [MAPK] , occurred also after Ca ( ++ ) depletion . Positive_regulation MAPK1 ALOX5 21200133 2391678 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Positive_regulation MAPK1 ANGPT1 12039842 954276 Accordingly , ephrinB2 inhibited VEGF- and *induced* [Ras-MAPK] activities , whereas ephrinB2 did not alter VEGF induced Flk phosphorylation or Ang1 induced Tie2 phosphorylation . Positive_regulation MAPK1 ANGPT1 12213710 985633 Both VEGF and *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 [MAPK] . Positive_regulation MAPK1 ANGPT1 12213726 985703 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of and Ang-2 as well as the *activation* of [MAPK] , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation MAPK1 ANGPT1 16049136 1459903 Overexpression of antioxidants ( superoxide dismutase and catalase ) and Rac1N17 , as well as preincubation with selective inhibitors of NADPH oxidase augmented basal p38 phosphorylation , inhibited Ang-1 induced PAK-1 phosphorylation and potentiated *induced* [Erk1/2] phosphorylation but had no influence on AKT and SAPK/JNK phosphorylation by Ang-1 . Positive_regulation MAPK1 ANGPT1 16061664 1439064 *activated* [mitogen activated protein kinase (MAPK)] and phosphoinositide 3-kinase (PI3K) in IBE cells and HUVECs . Positive_regulation MAPK1 ANGPT1 16679392 1612148 Pretreatment with either DPI or apocynin also significantly attenuated *induced* Akt and p44/42 [MAPK] phosphorylation . Positive_regulation MAPK1 ANGPT1 16679392 1612164 Using mouse heart microvascular endothelial cells from wild-type ( WT ) mice and mice deficient in the p47(phox) component of NADPH oxidase ( p47 ( phox-/- ) ) , we found that although *stimulated* intracellular ROS , Akt and p42/44 [MAPK] phosphorylation , and cell migration in WT cells , the responses were strikingly suppressed in cells from the p47 ( phox-/- ) mice . Positive_regulation MAPK1 ANGPT1 19615361 2124100 Treatment of HUVECs with the lipid raft disrupting agent methyl-beta-cyclodextrin selectively inhibited *induced* Akt phosphorylation , but not [Erk1/2] phosphorylation . Positive_regulation MAPK1 ANGPT1 20072135 2235282 *promoted* skin cell metabolism/viability , adhesion , and akt and [MAPK] ( p42/44 ) activations . Positive_regulation MAPK1 ANO1 22564524 2619157 *induces* [MAPK] and contributes directly to tumorigenesis and cancer progression . Positive_regulation MAPK1 CAPN8 21543591 2424047 Downstream , an Aß-mediated rise in p38 [mitogen activated protein kinase (MAPK)] activation was followed by downregulation of cAMP response element binding protein , and LTP impairment was *prevented* by inhibitors of p38 MAPK or . Positive_regulation MAPK1 CAPN8 24416390 2900915 Treatment with glutamate leads to early activation of NMDAR , which in turn leads to *mediated* cleavage of striatal enriched protein tyrosine phosphatase ( STEP ) and subsequent activation of p38 [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK1 CCL17 23711854 2792882 IL-33 induced the production of thymus and activation regulated and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 [MAPK] . Positive_regulation MAPK1 CCND1 11004713 735006 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping [ERK-MAPK] activation and c-Fos and *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation MAPK1 CCND1 12654183 1072979 [MAPK] may *induce* overexpression of protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation MAPK1 CCND1 15020686 1221644 Double stranded small RNA interference ( siRNA ) by silencing endogenous p130Cas protein , was sufficient to inhibit estrogen dependent [Erk1/2] MAPKs activity and *induction* , demonstrating the requirement of p130Cas in such events . Positive_regulation MAPK1 CCND1 15634644 1349549 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 [mitogen activated protein kinase] , and down-regulation of . Positive_regulation MAPK1 CCND1 16522728 1531453 We conclude that incretin induced beta-cell replication is dependent on cAMP/PKA , p42 [MAPK] and PI3K activities , which may *involve* transcriptional induction of . Positive_regulation MAPK1 CCND1 19443725 2136034 EGF *induced* increases in paxillin Ser-126 phosphorylation and expression through transient [Erk1/2] phosphorylation . Positive_regulation MAPK1 CCND1 24375433 2917201 While secondary stimulation resulted in strongly decreased replication rate , we did not observe any attenuation of morphological changes , [Erk1/2] phosphorylation and *induction* . Positive_regulation MAPK1 CCND1 9537433 497550 Furthermore , in 25 of 26 cases of HCC which genomic DNA was available , 22 cases without genomic DNA amplification exhibited positive correlation , not only between protein expression of c-Fos and , but also between [MAPK/ERK] *activation* and cyclin D1 expression . Positive_regulation MAPK1 CD14 15625444 1349232 LPS interacts with the cell surface receptor , which generates transmembrane signals through Toll-like protein 4 *leading* to [mitogen activated protein kinase (MAPK)] p38 activation , cytokine synthesis , PMN beta2-integrin expression and oxidative burst . Positive_regulation MAPK1 CD22 10438726 635016 Concurrent ligation of and BCR *enhanced* BCR mediated [ERK-2] activation without appreciably modulating CD22 induced SAPK activation . Positive_regulation MAPK1 CHI3L1 23755018 2797723 In addition , *induces* [FAK-MAPK] signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation MAPK1 CHI3L1 23972995 2836235 We also demonstrate that *activates* macrophage [mitogen activated protein kinase] , protein kinase B/AKT , and Wnt/ß-catenin signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation MAPK1 CLU 23051594 2702800 FOXL2 directly stimulates the Clu gene promoter , and we show that PTTG triggers ataxia telangiectasia mutated [kinase/IGF-I/p38MAPK] DNA damage/chromosomal instability signaling , which in turn also *induces* expression . Positive_regulation MAPK1 CTGF 11732999 885258 *induces* chondrocyte differentiation through a p38 [mitogen activated protein kinase] ( p38MAPK ) , and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase ( ERK ) . Positive_regulation MAPK1 CTGF 11732999 885272 In the proliferation phase , *induced* a approximately fivefold increase in the phosphorylation of p44/42 [MAPK/ERK] and a approximately twofold increase in that of p38 MAPK in an in vivo kinase assay . Positive_regulation MAPK1 CTGF 12218048 1012158 The inhibition of *induced* p42/44 [MAPK] or phosphatidylinositol 3-kinase (PI3K)/protein kinase B pathway activities abrogated the induction of fibronectin expression . Positive_regulation MAPK1 CTGF 16408113 1513473 *enhanced* the mRNA expression and protein release of fractalkine , MCP-1 , and RANTES , the expression of phospho ( P ) -p42/44 [mitogen activated protein kinase (MAPK)] , P-phosphoinositide 3-kinase (PI3-K) , P-Akt , and activity of nuclear factor-kappaB (NF-kappaB) in mesangial cells . Positive_regulation MAPK1 CTGF 16408113 1513493 P-p42/44 MAPK blockade inhibited the *induced* expression of P-p42/44 [MAPK] but not NF-kappaB , and partially decreased the levels of the above chemokines in supernatants . Positive_regulation MAPK1 CTGF 16522717 1531321 ( 3 ) *stimulated* dose dependent HSC adhesion and activity of p42/p44 [mitogen activated protein kinase] , the latter of which was antagonized by blocking the activity of focal adhesion kinase . Positive_regulation MAPK1 CTGF 16938382 1654120 No single module , but a mixture of the 4 modules provoked a significant activation of p38 [MAPK] in HCS-2/8 cells , which was *activated* by the full-length . Positive_regulation MAPK1 CTGF 19038999 2023075 Interestingly , CCN2-BMP-2 did not affect the *induced* phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Positive_regulation MAPK1 CTGF 20213804 2249225 *induced* phosphorylation of p38 , [ERK-1/2] , JNK , and Akt , but not Smad3 , in transgenic mouse fibroblasts compared with wild-type mouse fibroblasts . Positive_regulation MAPK1 CTGF 21645240 2579214 In tibialis anterior muscle overexpressing CTGF using an adenovirus , ARB treatment decreased mediated *increase* of ECM molecules , a-SMA and [ERK-1/2] phosphorylation levels . Positive_regulation MAPK1 CTGF 21760921 2456299 Recombinant *activated* Src and [Erk1/2] signaling , and induced phosphorylation of Fli1 , but was unable to stimulate Smad1 or Smad3 phosphorylation . Positive_regulation MAPK1 EDN2 12193071 980919 The molecular mechanisms of dependent *activation* of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Positive_regulation MAPK1 EDN2 12475899 1037757 *induced* a rapid phosphorylation of the [mitogen activated protein kinase (MAPK)/ERK] and increased collagen I gene activity in freshly isolated aortas . Positive_regulation MAPK1 EDN2 1280103 203024 rapidly *stimulates* [mitogen activated protein kinase] activity in rat mesangial cells . Positive_regulation MAPK1 EDN2 12855582 1149875 also *induced* the activation of p42/44 [mitogen activated protein kinase (MAPK)] in DCs . Positive_regulation MAPK1 EDN2 15662221 1365133 Moreover , did not *enhance* the phosphorylation of [ERK 1/2] in small mesenteric arteries . Positive_regulation MAPK1 EDN2 7509933 241591 *stimulates* [mitogen activated protein kinase] p42 activity through the phosphorylation of the kinase in rat mesangial cells . Positive_regulation MAPK1 EDN2 7849246 286715 *stimulates* [mitogen activated protein kinase] activity in mesangial cells through ETA . Positive_regulation MAPK1 EDN2 7943276 276382 has been shown to *activate* [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK1 EDN2 8836145 386156 In bovine airway smooth-muscle cells platelet derived growth factor ( PDGF ) and ( Et-1 ) *stimulate* sustained and comparable activation of [mitogen activated protein kinase] ( MAP kinase ) but display very different mitogenic efficacies , with PDGF inducing 50 times more DNA synthesis than Et-1 . Positive_regulation MAPK1 EFNB1 15502157 1347556 Further downstream of the signaling pathway , stimulation *led* to increased LAT ( linker for activation of T-cells ) phosphorylation and p44/42 and p38 [MAPK] activation . Positive_regulation MAPK1 EPHB2 10601128 574192 Tumor necrosis factor-alpha (TNF-alpha) alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only . Positive_regulation MAPK1 EPHB2 10872747 707021 Pre-treatment of the cells with PD98059 , a selective pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation MAPK1 EPHB2 10898713 712108 H ( 2 ) O ( 2 ) mediates changes in [ERK1/ERK2] phosphorylation , increases endothelial solute permeability , and alters occludin localization and phosphorylation were all *blocked* by PD-98059 , a specific mitogen activated protein ( MAP ) or kinase 1 inhibitor . Positive_regulation MAPK1 EPHB2 11083274 750487 Tumor necrosis factor alpha , interleukin-1 (IL-1) , and IL-6 were the major inducers of , JNK , and p38 [MAPK] *activation* in cultured human synovial cells . Positive_regulation MAPK1 EPHB2 12220664 987040 The inhibitor of activation PD98059 abolished caspase activation , but caspase inhibition did not *reduce* [ERK 1/2] phosphorylation , suggesting that ERK activation is placed upstream of caspases . Positive_regulation MAPK1 EPHB2 12386816 999759 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 [MAPK] and a biphasic *activation* of . Positive_regulation MAPK1 EPHB2 12403788 1036171 SB203580 , a p38 [MAPK] *inhibitor* , and PD98059 , an inhibitor , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation MAPK1 EPHB2 12435596 1015863 We found that thrombin induced mitogen activated protein kinase ( MEK)1/2 activation was *necessary* for [ERK2] phosphorylation . Positive_regulation MAPK1 EPHB2 12486127 1056304 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain *had* little effect on basal Erk [MAPK] activation . Positive_regulation MAPK1 EPHB2 12511425 1070733 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation MAPK1 EPHB2 12801927 1120228 GE2 stimulation *induced* phosphorylation , whereas it did not alter the phosphorylation of c-Jun N-terminal kinase or p38 [MAPK] . Positive_regulation MAPK1 EPHB2 12832293 1105573 Exposure to E. coli DNA resulted in phosphorylation of ERK 1/2 [MAPK] and inhibitors of activity ( PD98059 , UO126 ) significantly *reduced* the evoked IL-8 production . Positive_regulation MAPK1 EPHB2 12878192 1115515 ( 2 ) the *activation* of JNK and p38 [MAPK] but not in embryonic fibroblasts ( MEFs ) derived from ASK1 knockout mice ( ASK1 ( -/- ) MEFs ) was depressed compared to MEFs derived from wild type mice ( ASK1 ( +/+ ) MEFs ) ; Positive_regulation MAPK1 EPHB2 14973553 1212504 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen activated protein kinase (MAPK)] signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation MAPK1 EPHB2 14998726 1216726 Furthermore , we found that PD98059 , an pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation MAPK1 EPHB2 15659876 1350299 The anabolic effect of TNF-alpha was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an . Positive_regulation MAPK1 EPHB2 16038626 1437399 SF significantly prevented Abeta induced increases in IL-1beta and p38 [MAPK] *activation* and also Abeta induced changes in and phospho-Akt/PKB expression levels . Positive_regulation MAPK1 EPHB2 17056059 1649523 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Positive_regulation MAPK1 EPHB2 17403539 1735930 Trauma-hemorrhage increased the production of IL-6 , IL-10 , IL-12 and TNF-alpha enhanced the expression of TLR4 , MyD88 as well as the *activation* of [MAPK] proteins ( p38 , and JNK ) in epidermal keratinocytes . Positive_regulation MAPK1 EPHB2 17416211 1777847 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK1 EPHB2 17464174 1731741 The mRNA and surface protein up-regulation of CCR1 and CCR2 in 9CRA stimulated cells were weakly blocked by the pretreatment of SB202190 , a p38 [MAPK] *inhibitor* , and PD98059 , an upstream inhibitor . Positive_regulation MAPK1 EPHB2 17879163 1818404 Treatment with V+H- decreased the phosphorylation of extracellular signal regulated kinase ( ERK ) 1 and 2 , and direct activation of by constitutively active MEK1 , an ERK kinase , *increased* ERK1 and [ERK2] phosphorylation and inhibited the increase in apoptosis induced by V+H- . Positive_regulation MAPK1 EPHB2 18164124 1869606 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 [MAPK] , but not by the *activation* of JNK , , and NF-kappaB pathway . Positive_regulation MAPK1 EPHB2 18266967 2000291 VEGF induced activation of p42 also *led* to the nuclear translocation of [MAPK/ERK1/2] . Positive_regulation MAPK1 EPHB2 18285354 1885402 Pre-treatment with the [MAPK] *inhibitors* SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( inhibitor ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation MAPK1 EPHB2 18338254 1938054 Interestingly , inhibition of by U0126 completely *prevented* artepillin C-induced p38 [MAPK] phosphorylation of PC12m3 cells . Positive_regulation MAPK1 EPHB2 18520049 1918669 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of , rather than by the *activation* of p38 [MAPK] , in the spinal cord . Positive_regulation MAPK1 EPHB2 18982426 2105743 These inhibitory effects were partially inhibited by SB203580 , a specific *inhibitor* of p38 [MAPK] , but not by PD98059 , a specific inhibitors of extracellular signal regulated kinase ( ) , and SP600125 , a specific inhibitor of c-Jun-N-terminal kinase (JNK) . Positive_regulation MAPK1 EPHB2 19189219 2113958 Moreover , EM1 treatment resulted in less activation of p38 [MAPK] and more *activation* of signaling in lipopolysaccharide stimulated DCs . Positive_regulation MAPK1 EPHB2 19276187 2051414 Treatment of cells with sphingosine induced suppression of and *activation* of p38 [MAPK] . Positive_regulation MAPK1 EPHB2 19429670 2106917 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either inhibitor , [p38MAPK] *inhibitor* or NF-kappaB inhibitor . Positive_regulation MAPK1 EPHB2 19522739 2103137 Treatment with [MAPK] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation MAPK1 EPHB2 19672126 2168059 A scratch wound assay of healing rates in SV40 immortalized human corneal epithelial cell line ( HCEC ) evaluated the relative contributions by p38 and and JNK [MAPK] signaling *activation* to wound healing . Positive_regulation MAPK1 EPHB2 20025124 2175509 Prior treatment of the cells with PD98059 , an kinase inhibitor or SB203580 , a [p38MAPK] *inhibitor* , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation MAPK1 EPHB2 20554538 2327618 The HNE enhanced Sp1 and NF-?B activities were attenuated by SB203580 , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , and PD98059 , an extracellular signal regulated kinase ( ) inhibitor , respectively . Positive_regulation MAPK1 EPHB2 21126656 2355795 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 [mitogen activated protein kinase] , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by . Positive_regulation MAPK1 EPHB2 21311676 2360030 Treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation MAPK1 EPHB2 21488184 2417969 Dexmedetomidine induced phosphorylation of JNK and p38 [MAPK] in rat aortic SMCs , but did not *induce* phosphorylation of . Positive_regulation MAPK1 EPHB2 21586573 2449662 Incubation of T cells with ESAT-6 induced phosphorylation and increased functional p38 [MAPK] activity , but not *activation* of or JNK . Positive_regulation MAPK1 EPHB2 21599960 2445718 In the present studies , induction of central sensitization as indicated by spinal dorsal horn [MAPK] *activation* , specifically and p38 phosphorylation , was assessed in the MIA-OA model . Positive_regulation MAPK1 EPHB2 23394443 2713228 When compared to hamsters bearing tumors that remained on the control diet , the buccal pouches of hamsters bearing tumors receiving turmeric showed the following results : ( 1 ) decreased cell proliferation ( diminished PCNA , cyclin D1 , and Bcl-2 ) and PCNA labelling index , ( 2 ) enhanced apoptosis ( increased Bax , caspase-3 , caspase-9 , and cytochrome c , and decreased survivin ) and apoptotic index , ( 3 ) decreased inflammation ( decreased Cox-2 ) , and ( 4 ) decreased [MAPK] *activation* ( and p-p38 ) . Positive_regulation MAPK1 EPHB2 23892041 2830331 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three [MAPK] *inhibitors* ( inhibitor PD98059 , JNK inhibitor SP600125 and p38 inhibitor SB203580 ) . Positive_regulation MAPK1 EPHB2 23914844 2840567 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 [MAPK] and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of , JNK , NF-?B . Positive_regulation MAPK1 EPHB2 23917355 2826011 Inhibition of Akt or activity *reduced* phosphorylation of STAT1 in Colon26L5-CUG2 cells whereas inhibition of p38 [MAPK] did not significantly decrease levels of STAT1 phosphorylation , indicating that cell proliferation signals may be involved in CUG2 mediated activation of STAT1 . Positive_regulation MAPK1 EPHB2 24225419 2897491 Therefore , by using the [MAPK] *inhibitors* SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific inhibitor ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation MAPK1 EPHB2 24297112 2894211 Following treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation MAPK1 F2R 16052512 1460021 The p38 and ERK1/2 [MAPK] signaling cascades were also *activated* by stimulation , whereas the SAPK/JNK pathway was unaffected . Positive_regulation MAPK1 F2R 16467309 1548145 and PAR-2 stimulation rapidly *activated* both ERK1/2 and [p38MAPK] , and pharmacological blockade of MEK with either PD98059 or U0126 or of p38MAPK by SB203580 or SB202190 strongly inhibited thrombin- and SLIGKV induced COX-2 expression and 6-keto-PGF1alpha formation . Positive_regulation MAPK1 F2R 19683795 2208952 The EPCR dependent cleavage of by both APC and thrombin *increased* the phosphorylation of [ERK 1/2] . Positive_regulation MAPK1 F2R 21252088 2402881 In the present study , we show that FVIIa , upon binding to EPCR on endothelial cells , activates endogenous protease activated receptor-1 (PAR1) and induces mediated p44/42 [mitogen activated protein kinase (MAPK)] *activation* . Positive_regulation MAPK1 F2R 24052258 2867012 However , the distinct non-canonical tethered ligands unmasked by neutrophil elastase and proteinase-3 , as well as synthetic peptides with sequences derived from these novel exposed tethered ligands , selectively stimulated mediated [mitogen activated protein kinase] *activation* . Positive_regulation MAPK1 F2R 8635212 357837 These results support the notion that the *activates* [MAPK] through PKC dependent pathways and that the incremental activation of MAPK by TRAP over that induced by thrombin is the consequence of enhanced activation through the PKC limb of the phosphoinositide lipid pathway . Positive_regulation MAPK1 FAS 14576831 1156601 A more physiological inhibitor , the intracellular PP2A inhibitor protein I2 ( PP2A ) , protected transfected HeLa cells in a similar way from mediated apoptosis and induced *activation* of [MAPK] in I2 ( PP2A ) transfected cells . Positive_regulation MAPK1 FAS 15280387 1302528 We further demonstrate that this pro-apoptotic effect of CO was independent of reactive oxygen species production and involved inhibition in induced *activation* of the pro-survival ERK [MAPK] . Positive_regulation MAPK1 FAS 16507991 1529627 Here we show that binding of Fas ligand to *activates* p38 [MAPK] in CD8+ T cells and that activation of this pathway is required for Fas mediated CD8+ T-cell death . Positive_regulation MAPK1 FAS 19417161 2179806 GST-MDA-7 killing was , in parallel , dependent on inactivation of extracellular signal regulated kinase 1/2 and on *induced* p38 [mitogen activated protein kinase] and c-jun NH ( 2 ) -terminal kinase-1/2 signaling . Positive_regulation MAPK1 FAS 21613257 2454272 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Positive_regulation MAPK1 FAS 21975294 2492839 Caspase-8 activity has an essential role in *mediated* [MAPK] activation . Positive_regulation MAPK1 FAS 8846779 338011 cross linking *resulted* also in [ERK-2] activation and in phospholipase A2 (PLA2) induction , independently of the PC-PLC/aSMase pathway . Positive_regulation MAPK1 FAS 8977313 403342 IFN-alpha2 did not alter the *induced* activity of [Mitogen activated protein kinase (MAPK)] 1 and did not inhibit the Apo-1/Fas mediated proteolytic cleavage of ADP-ribosyltransferase , a substrate of Interleukin-beta1 converting enzyme ( ICE ) and homologues . Positive_regulation MAPK1 FGFBP1 11509569 868518 Furthermore , *enhances* FGF-1- and FGF-2 dependent proliferation of NIH-3T3 fibroblasts and FGF-2 induced [extracellular signal regulated kinase 2] phosphorylation . Positive_regulation MAPK1 FHL1 23456229 2781813 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Positive_regulation MAPK1 FOXA1 22879989 2641678 An increase in IGFBP-3 , mediated by depletion of , *inhibited* phosphorylation of [MAPK] and Akt , and increased expression of the cell cycle regulators p21 and p27 . Positive_regulation MAPK1 FUT4 20506505 2307951 These data suggested that not only *activates* [MAPK] and PI3K/Akt signals , but also promotes the crosstalk among these signaling pathways . Positive_regulation MAPK1 GLP1R 21356521 2394811 activation by Exendin-4 ( Ex-4 ) *increased* PKA and [MAPK] activity and decreased phosphorylation of AMPK in NTS . Positive_regulation MAPK1 GPR115 10958680 725051 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK1 GPR115 11916960 944803 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK1 GPR115 18211822 1870681 Recent studies have demonstrated that the mitogenic effects of LDL are accompanied by [Erk1/2] *activation* via an unknown . Positive_regulation MAPK1 GPR115 20576526 2302990 In many cell types , *induced* [Erk1/2] MAP kinase activation is mediated via receptor tyrosine kinase ( RTK ) transactivation , in particular via the epidermal growth factor (EGF) receptor . Positive_regulation MAPK1 GPR115 9182581 434997 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK1 GPR115 9826186 549394 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK1 GPR132 10958680 725040 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK1 GPR132 11474113 841734 Activation of by LPC *increased* intracellular calcium concentration , induced receptor internalization , activated ERK [mitogen activated protein kinase] , and modified migratory responses of Jurkat T lymphocytes . Positive_regulation MAPK1 GPR132 11916960 944792 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK1 GPR132 18211822 1870670 Recent studies have demonstrated that the mitogenic effects of LDL are accompanied by [Erk1/2] *activation* via an unknown . Positive_regulation MAPK1 GPR132 20576526 2302979 In many cell types , induced [Erk1/2] MAP kinase *activation* is mediated via receptor tyrosine kinase ( RTK ) transactivation , in particular via the epidermal growth factor (EGF) receptor . Positive_regulation MAPK1 GPR132 9182581 434986 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on mediated *activation* of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK1 GPR132 9826186 549383 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK1 GPR87 10958680 725120 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK1 GPR87 11916960 944872 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK1 GPR87 18211822 1870750 Recent studies have demonstrated that the mitogenic effects of LDL are accompanied by [Erk1/2] *activation* via an unknown . Positive_regulation MAPK1 GPR87 20576526 2303059 In many cell types , induced [Erk1/2] MAP kinase *activation* is mediated via receptor tyrosine kinase ( RTK ) transactivation , in particular via the epidermal growth factor (EGF) receptor . Positive_regulation MAPK1 GPR87 9182581 435066 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK1 GPR87 9826186 549463 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK1 HBEGF 10544013 563919 also rapidly *activated* [MAPK] and induced cyclin D1 in mid-G1 with kinetics similar to TGFalpha . Positive_regulation MAPK1 HBEGF 11171084 783790 Both p42 [MAPK] activation and mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation MAPK1 HBEGF 15380451 1298476 *induced* phosphorylation of ERK , p38 [MAPK] and Akt , which were suppressed by ZD1839 . Positive_regulation MAPK1 HBEGF 17928891 1858620 We report that cellular stress with methyl-beta-cyclodextrin ( MBCD ) , a molecule that extracts membrane cholesterol and thereby disrupts the structure of lipid rafts , strongly *induces* the synthesis of ( HB-EGF ) in keratinocytes through the activation of p38 [mitogen activated protein kinase] . Positive_regulation MAPK1 HBEGF 18990151 2028919 *Activation* of [Erk/MAPK] by was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation MAPK1 HBEGF 19048624 2023712 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked [MAPK] signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 MAPK , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Positive_regulation MAPK1 HBEGF 19559571 2110500 *induced* phosphorylation of p42/p44 [MAPK] in a few minutes . Positive_regulation MAPK1 HBEGF 20739666 2345885 Moreover , *induced* a stronger and more sustained activation of both the [mitogen activated protein kinase] and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation MAPK1 HBEGF 24188029 2921094 Here , we show that *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , [Mapk/Erk] pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation MAPK1 HRH1 11959800 931437 1. Previous studies have shown that the *activates* p42/p44 [mitogen activated protein kinases (MAPK)] in DDT ( 1 ) MF-2 smooth muscle cells via a phosphatidylinositol 3-kinase (PI-3K) dependent pathway . Positive_regulation MAPK1 HRH1 17965772 1820335 is *required* for TCR mediated p38 [MAPK] activation and optimal IFN-gamma production in mice . Positive_regulation MAPK1 HRH1 17965772 1820349 Moreover , signaling at the time of TCR ligation was *required* for activation of p38 [MAPK] , a known regulator of IFN-gamma expression . Positive_regulation MAPK1 IFI27 16953232 1682566 RET2A mediated regulation of p18 and , but not of cyclins D1 and D2 , *requires* functional [mitogen activated protein kinase] signaling . Positive_regulation MAPK1 IL1B 10089132 600009 Our previous work showed that also *activates* the MAP kinase [ERK2] in human mesangial cells . Positive_regulation MAPK1 IL1B 10640438 577496 and TNF alpha also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK1 IL1B 10704772 673001 CPI-1189 inhibits *induced* [p38-mitogen activated protein kinase] phosphorylation : an explanation for its neuroprotective properties ? Positive_regulation MAPK1 IL1B 10775561 686640 *activated* p44/42 [MAPK] , and this activation was enhanced in the presence of N-acetyl-L-cysteine . Positive_regulation MAPK1 IL1B 10864897 705718 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK1 IL1B 10864897 705770 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by TNF-alpha and . Positive_regulation MAPK1 IL1B 10864897 705794 TNF-alpha- and *induced* [ ( 3 ) H ] -thymidine incorporation and phosphorylation of p42/p44 [MAPK] was completely inhibited by PD98059 ( an inhibitor of MEK1/2 ) , indicating that activation of MEK1/2 was required for these responses . Positive_regulation MAPK1 IL1B 10969830 728482 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Positive_regulation MAPK1 IL1B 11032891 740450 *induces* p38 [MAPK] phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation MAPK1 IL1B 11037878 741237 also *stimulated* phosphorylation of p38 [MAPK] , SAPK/JNK , and ATF-2 . Positive_regulation MAPK1 IL1B 11126408 759769 TNFalpha and IFNgamma potentiate *induced* [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK1 IL1B 11126408 759782 [Mitogen activated protein kinase (MAPK)] activity that is *induced* by has been suggested to signal nitric oxide dependent as well as nitric oxide independent beta-cell destructive pathways . Positive_regulation MAPK1 IL1B 11126408 759795 The aim of this study was to investigate if TNFalpha and IFNgamma signal through mitogen activated protein kinases in isolated rat islets of Langerhans and if they potentiate [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK1 IL1B 11126408 759808 Further , TNFalpha and IFNgamma were found to synergistically increase [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK1 IL1B 11281731 764733 *Activation* of [Erk1/Erk2] by IGF1 and was studied using a phosphorylation-specific antibody . Positive_regulation MAPK1 IL1B 11399523 824256 Glucose potentiates *induced* p38 [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK1 IL1B 11509550 848350 Although and TNF-alpha each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK1 IL1B 11557585 861399 *activated* the three [mitogen activated protein kinase] ( extracellular signal regulated kinases 1 and 2 , c-Jun NH2-terminal kinase/stress activated protein kinase , and p38 ) and the Janus kinase (JAK)-signal transducer and activator of transcription pathways . Positive_regulation MAPK1 IL1B 11698472 878048 *induced* phosphorylation and activation of p38 [MAPK] and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation MAPK1 IL1B 11698472 878094 *induced* phosphorylation of ERK and JNK as well as p38 [MAPK] in human endothelial cells . Positive_regulation MAPK1 IL1B 11728947 884805 We showed a dramatic decrease in *induced* phosphorylation of p38 [MAPK] , not extracellular signal regulated kinases 1/2 or jun NH2-terminal kinase , in rat cultured mesangial cells by FR167653 . Positive_regulation MAPK1 IL1B 11775830 766433 Role of protein tyrosine kinase in *induced* activation of [mitogen activated protein kinase] in fibroblast-like synoviocytes of rheumatoid arthritis . Positive_regulation MAPK1 IL1B 11853544 913367 Interestingly , *induced* p38 [MAPK] activity was greatly enhanced in ( alg+ ) compared with ( alg- ) cells . Positive_regulation MAPK1 IL1B 12117921 964661 mRNA expression by neutrophils was not dependent on p38 MAPK , and p38 [MAPK] was not *activated* in neutrophils incubated with A. phagocytophila . Positive_regulation MAPK1 IL1B 12131776 966851 and TNF-alpha *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK1 IL1B 12139924 969392 Regarding intracellular signaling , *activated* the p38 mitogen activated protein kinase (MAPK) but not the p42/p44 [MAPK] and , when combined with growth factors , intensified p38 activation but inhibited the growth-factor induced p42/p44 activation . Positive_regulation MAPK1 IL1B 12356282 993818 induced p44/42 [mitogen activated protein kinase (MAPK)] *activation* was inhibited by the MAPK/extracellular signal regulated protein kinase ( MEK ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK1 IL1B 12417253 1012949 Sphondin ( 50 microM ) did not affect the induced *activations* of p44/42 MAPK , p38 [MAPK] , and JNK . Positive_regulation MAPK1 IL1B 12483539 1024818 Exogenous expression of either SHPS-1 mutants that lack SHP-2 binding function or a dominant negative mutant of SHP-2 markedly inhibited the *activation* of [Erk 1/2] and Akt by , whereas wild type SHPS-1 did not . Positive_regulation MAPK1 IL1B 12498315 1026316 *activated* nuclear factor-kappaB , activator protein-1 , and three classes of mitogen activated protein ( MAP ) kinases : [extracellular signal regulated kinase1/2] , c-Jun N-terminal kinase , and p38 MAP kinase . Positive_regulation MAPK1 IL1B 12500176 1026683 These data suggest that the presence of retinal holes and may *lead* to activation of HGF , [mitogen activated protein kinases (MAPK)] , c-jun and extracellular matrix remodeling , resulting in proliferative and migratory cells in the wounded retina . Positive_regulation MAPK1 IL1B 12507586 1038417 In this study we evaluated the role of epigallocatechin-3-gallate ( EGCG ) , a green tea polyphenol which mimics its anti-inflammatory effects , in modulating the induced *activation* of [MAPK] 's in human chondrocytes . Positive_regulation MAPK1 IL1B 12649265 1080063 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant MKK6 or p38beta2 MAPK inhibited induced p38 [MAPK] *activation* , COX-2 gene expression , and PGE2 release . Positive_regulation MAPK1 IL1B 12727980 1086553 P38 [MAPK] phosphorylation was *increased* by in nondecidualized ESC , whereas the IL-1 beta induced increase was suppressed in the decidualized cells . Positive_regulation MAPK1 IL1B 12727980 1086566 Treatment with 8-bromo-cAMP reduced *induced* phosphorylation of p38 [MAPK] in nondecidualized ESC . Positive_regulation MAPK1 IL1B 12727980 1086580 In contrast , treatment with H89 , a protein kinase A inhibitor , reversed a reduction in *induced* p38 [MAPK] phosphorylation in the decidualized cells . Positive_regulation MAPK1 IL1B 12727980 1086594 The altered property of decidualized cells is thought to be caused by attenuation of *induced* p38 [MAPK] phosphorylation in a way that involves the activation of the cAMP/protein kinase A pathway . Positive_regulation MAPK1 IL1B 12882449 1116285 NAC ( 1 mM ) also decreased the induced *activation* of p38 [MAPK] . Positive_regulation MAPK1 IL1B 12952251 1137413 Using Western-blot analysis , no effect of cAMP was found on the *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK1 IL1B 12952251 1137427 No decrease was observed in *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK1 IL1B 14563491 1154856 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Positive_regulation MAPK1 IL1B 15039421 1251227 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of , and RIP2 dependent *activation* of NF-kappaB and p38 [MAPK] mediated by the caspase recruitment domain . Positive_regulation MAPK1 IL1B 15111866 1241235 We further demonstrated that p38 MAPK is activated by and PDGF with different kinetics and that p38 [MAPK] is *required* for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation MAPK1 IL1B 15208668 1281339 *induced* the activation of extracellular signal regulated kinases-1/2 and P38 [mitogen activated protein kinase (MAPK)] , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation MAPK1 IL1B 15341531 1291757 In accordance with these findings , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) , which was attenuated by U0126 , SB202190 , or SP600125 , respectively . Positive_regulation MAPK1 IL1B 15389584 1354315 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] and JNK which was attenuated by pretreatment with U0126 or SP600125 , respectively . Positive_regulation MAPK1 IL1B 15489374 1359419 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and JNK was attenuated by pretreatment with U0126 , SB-202190 , or SP-600125 , respectively . Positive_regulation MAPK1 IL1B 15755725 1403417 The inhibitory effect of on alpha ENaC expression was *mediated* by the activation of p38 [MAPK] in both rat and human ATII cells and was independent of the activation of alpha v beta6 integrin and transforming growth factor-beta . Positive_regulation MAPK1 IL1B 16002736 1431020 *activates* both p38 and [ERK 1/2] components of the MAPK pathways . Positive_regulation MAPK1 IL1B 16033422 1436161 Intrathecal *leads* to a time dependent up-regulation of phosphorylated p38 ( p-p38 ) [MAPK] protein expression in the spinal cord 30-240 min following IL-1beta injection ( i.t. ) . Positive_regulation MAPK1 IL1B 16033422 1436175 However , pretreatment with a p38 MAPK inhibitor significantly reduced the *induced* p-p38 [MAPK] expression by 38-49 % , and nearly completely blocked the subsequent iNOS expression ( reduction by 86.6 % ) , NO production , and thermal hyperalgesia . Positive_regulation MAPK1 IL1B 16043966 1459737 Western blot analysis demonstrated that *increased* the activation of phosphorylated MEK and p38 [MAPK] in GH3 cells . Positive_regulation MAPK1 IL1B 16140882 1450801 *induced* phosphorylation of [p38-MAPK] , but not that of c-Jun-N-terminal kinase or extracellular regulated kinase , was most susceptible to inhibition by low doses of PFE , and the addition of PFE blocked the activity of p38-MAPK in a kinase activity assay . Positive_regulation MAPK1 IL1B 16141635 1454865 DHA stimulated both rapid and prolonged activation of p44/42 , but not p38 , [mitogen activated protein kinase (MAPK)] *induced* by and PMA . Positive_regulation MAPK1 IL1B 16153910 1455429 The kidney was analyzed for expression of tumor necrosis factor alpha , , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 [mitogen activated protein kinase] , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation MAPK1 IL1B 16258191 1477774 Proinflammatory cytokine *caused* a transient activation of [Erk1/2] , p38 , and JNK in immortalized human T/C28a2 chondrocytes and that was followed by enhanced COX-2 expression and PGE2 production . Positive_regulation MAPK1 IL1B 16452991 1611729 Western blots showed that and TNF-alpha *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK1 IL1B 16528573 1549424 The aim of this study was to investigate if Gadd45b prevents *induced* beta cell [MAPK] signalling and apoptosis . Positive_regulation MAPK1 IL1B 16645161 1604673 significantly *increased* the phosphorylation of p38 [MAPK] and cPLA(2) . Positive_regulation MAPK1 IL1B 16698013 1575650 JST ( 0.01-1 mg/ml ) also attenuated the expression of cyclooxygenase (COX)-2 and activation of p38 [MAPK] *induced* by and A beta ( 1-42 ) . Positive_regulation MAPK1 IL1B 16718462 1584905 A synthetic peptide , C3d , reported to bind NCAM , did not activate MAPK or Akt as reported in neurons but inhibited *induced* [MAPK] activity , thereby mimicking the effect of SU5402 . Positive_regulation MAPK1 IL1B 16718462 1584930 We suggest that NCAM signalling through FGFR is required for efficient IL-1beta pro-apoptotic signalling by facilitating *induced* [MAPK] activation downstream of the NF-kappaB-MAPK branching point . Positive_regulation MAPK1 IL1B 16718462 1584957 Further , these data identify a novel function of C3d as an inhibitor of NCAM induced FGFR activity and of *induced* [MAPK] activation in beta cells . Positive_regulation MAPK1 IL1B 16959849 1639694 *caused* an increase in the phosphorylation of ERK , but not [p38MAPK] or c-Jun N-terminal kinase . Positive_regulation MAPK1 IL1B 16964394 1611550 Inhibitors of p38 [MAPK] and/or JNK significantly suppressed VEGF secretion both in the *presence* and absence of , while inhibitors of COX-2 , ERK1/2 , and PI3-K did not . Positive_regulation MAPK1 IL1B 17208222 1695809 Thalidomide also suppressed *induced* p38 [mitogen activated protein kinase (MAPK)] activation , while a p38 MAPK inhibitor destabilized COX-2 mRNA and the cytoplasmic shuttling of HuR induced by IL-1beta . Positive_regulation MAPK1 IL1B 17311279 1719286 *stimulated* phosphorylation of p42/p44 [MAPK] , p38 MAPK , and JNK was attenuated by pretreatment with U0126 , SB202190 , SP600125 , or transfection with these dominant negative mutants of MEK , ERK , p38 and JNK , respectively . Positive_regulation MAPK1 IL1B 17390080 1716126 We have previously demonstrated that *induced* HBD-2 mRNA expression in A549 cells through activation of nuclear factor-kappaB (NF-kappaB) transcriptional factor as well as p38 [mitogen activated protein kinase (MAPK)] , c-Jun N-terminal kinase (JNK) , or phosphatidylinositol-3-kinase (PI3K) . Positive_regulation MAPK1 IL1B 17390080 1716158 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Positive_regulation MAPK1 IL1B 17390080 1716188 Triptolide inhibited *induced* [MAPK] phosphatase-1 expression at the transcriptional level and resulted in sustained phosphorylation of JNK or p38 MAPK , explaining the little effect of triptolide on IL-1beta induced phosphorylation of these kinases . Positive_regulation MAPK1 IL1B 17438131 1742766 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by TNF-alpha and , but not by ansiomycin or sorbitol . Positive_regulation MAPK1 IL1B 17559635 1753258 also *activated* extracellular signal regulated kinase , p38 [MAPK] , and c-Jun N-terminal kinase . Positive_regulation MAPK1 IL1B 17645739 1793266 Interestingly , Dex attenuated mediated *activation* of p38 [MAPK] and JNK , but not of AKT . Positive_regulation MAPK1 IL1B 17694686 1782099 IL-1beta induced NO levels and thermal hyperalgesia in rats , likely via either inhibiting the mediated p38 [MAPK] *activation* and subsequent iNOS induction , or direct attenuation of the central iNOS activity , which therefore reduces the central sensitization of inflammatory pain . Positive_regulation MAPK1 IL1B 17920534 1804186 SA981 at a concentration of 100 microM partially inhibited *induced* phosphorylation of [p38MAPK] and Akt ( 12.0 % and 36.1 % inhibition of each total amount of phosphoprotein under IL-1beta coexistence condition , respectively ) . Positive_regulation MAPK1 IL1B 17925024 1835150 *stimulated* phosphorylation of c-jun amino-terminal kinase , p38 [MAPK] and extracellular signal regulated kinase-1/2 . Positive_regulation MAPK1 IL1B 17983423 1850440 Chondroitin sulfate reduced IL-1beta induced NF-kappaB nuclear translocation , but not AP-1 translocation , it decreased *induced* phosphorylation of [Erk1/2] and abrogated p38MAPK phosphorylation , but did not prevent IL-1beta induced increase in nitrite . Positive_regulation MAPK1 IL1B 18026701 1827817 Moreover , glucosamine suppressed the *induced* phosphorylation of p38 [MAPK] ( p < 0.05 at > 0.1 mM ) and the IL-1beta binding to its receptors ( p < 0.05 at 1 mM ) . Positive_regulation MAPK1 IL1B 18065201 1853659 *stimulated* activation of ERK1/2 and p38alpha [MAPK] mediates the transcriptional up-regulation of IL-6 , IL-8 and GRO-alpha in HeLa cells . Positive_regulation MAPK1 IL1B 18300858 1873451 However , the high concentration of D-glucose did increase iNOS expression in response to low concentrations of ( 2.5 and 5 ng/ml ) , as well as the IL-1beta induced *activation* of both [ERK 1/2] and NF-kappaB . Positive_regulation MAPK1 IL1B 18348730 1925311 The *activation* or inhibition of p38 [MAPK] by and/or SB203580 was analyzed by western blotting . Positive_regulation MAPK1 IL1B 18348730 1925324 *activated* the phosphorylation of p38 [MAPK] and this effect was abolished by SB203580 . Positive_regulation MAPK1 IL1B 18427719 1920719 Phosphorylated p38 ( Phos-p38 ) [mitogen activated protein kinase] was *stimulated* in SW-1353 cells by but not by HA alone . Positive_regulation MAPK1 IL1B 18556347 1965923 or leptin individually *induced* threonine/tyrosine phosphorylation of p38 [MAPK] , whereas only leptin induced tyrosine phosphorylation of JAK2 , suggesting that leptin may enhance hBD-2 production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with NF-kappaB , which is activated by IL-1beta . Positive_regulation MAPK1 IL1B 18667841 1948048 Furthermore , induced p38 [mitogen activated protein kinase (MAPK)] *activation* and upregulation of VEGF-C mRNA and protein in LLC cells was also suppressed by artemisinin or by the p38 MAPK inhibitor SB-203580 , suggesting that p38 MAPK could serve as a mediator of proinflammatory cytokine induced VEGF-C expression . Positive_regulation MAPK1 IL1B 19362079 2081455 *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 [mitogen activated protein (MAP) kinase] , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation MAPK1 IL1B 19446813 2141902 Furthermore , digitoxin prevented the induced *activation* of [p44/42-MAPK] and NF-kappaB without affecting activation of JNK and p38-MAPK . Positive_regulation MAPK1 IL1B 19522843 2136335 In chondrocytes , CS diminishes *induced* increases in p38 [mitogen activated protein kinase] ( p38MAPK ) and signal regulated kinase 1/2 ( Erk1/2 ) phosphorylation , and decreases nuclear factor-kappaB (NF-kappaB) nuclear translocation and as a consequence , reduces the formation of pro-inflammatory cytokines , IL-1beta and TNF-alpha , and pro-inflammatory enzymes , such as phospholipase A2 (PLA2) , cyclooxygenase 2 (COX-2) and nitric oxide synthase-2 (NOS-2) . Positive_regulation MAPK1 IL1B 19765281 2163519 Treatment with PIP-18 blocked *induced* p38 [MAPK] phosphorylation and resulted in attenuation of sPLA2-IIA and MMP mRNA transcription in RA SF cells . Positive_regulation MAPK1 IL1B 20060906 2218517 In the present study , we demonstrate that *caused* activation of p38 [mitogen activated protein kinase] and that the p38 inhibitor SB203580 significantly blocked the effect of IL-1beta on I ( NMDA-OUT ) in hippocampal CA1 neurons . Positive_regulation MAPK1 IL1B 20353947 2266456 In model 1 , a differentiation model , CLA *activation* of [MAPK] and induction of interleukin-8 (IL-8) , IL-6 , , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation MAPK1 IL1B 21659536 2455190 Distinct roles for Nod2 protein and autocrine in muramyl dipeptide *induced* [mitogen activated protein kinase] activation and cytokine secretion in human macrophages . Positive_regulation MAPK1 IL1B 24692548 2935241 At 1 h , this was responsible for the dexamethasone inhibition of induced [MAPK] *activation* and CXCL1 and CXCL2 mRNA expression , with a similar trend for CSF2 . Positive_regulation MAPK1 IL1B 8557638 347437 The farnesyl transferase inhibitor BZA-5B blocked activation of [ERK1/ERK2] and *induction* of NOS2 by IFN gamma and in myocytes . Positive_regulation MAPK1 IL1B 9475519 486787 Of these , *activated* only [MAPK] . Positive_regulation MAPK1 IL1B 9475519 486800 In cultured rat astrocytes , *caused* activation of [MAPK] without inducing proliferation . Positive_regulation MAPK1 IL1B 9575890 502723 Our data also indicate that both insulin and IGF-I enhance *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation and SAPK activation . Positive_regulation MAPK1 IL1B 9582321 503932 Previously we reported that *induces* activation of JNK/SAPK and p38 [MAPK] with concomitant up-regulation of cyclooxygenase (Cox)-2 expression and prostaglandin E2 ( PGE2 ) synthesis . Positive_regulation MAPK1 IL1B 9614146 509325 By Western blotting with phosphospecific antibodies and by immunocomplex kinase assay , was shown to *activate* extracellular signal regulated kinase ( ERK ) 1/2 and p38 [mitogen activated protein kinase] ( p38 ) in islets and rat insulinoma cells . Positive_regulation MAPK1 IL1B 9759865 536587 An investigation of MAP kinase signaling pathways revealed that or PDTC *activated* [extracellular signal regulated kinase-2] ( ERK-2 ) and c-jun NH2 terminal kinase-1 (JNK-1) phosphorylation of PHAS-1 and c-Jun substrates , respectively . Positive_regulation MAPK1 IL1B 9759865 536589 Pretreatment of cells with the MAP kinase kinase-1 (MEK1) inhibitor PD 98059 blocked *induced* activation of [ERK-2] by more than 90 % but enhanced IL-1beta stimulated induction of PDGF-Ralpha expression fourfold . Positive_regulation MAPK1 IL1B 9786861 540910 We reported previously that rapidly *activates* the c-Jun NH2-terminal/stress activated protein kinases ( JNK/SAPK ) and p38 [mitogen activated protein kinase (MAPK)] and also induces Cox-2 expression and prostaglandin E2 ( PGE2 ) production . Positive_regulation MAPK1 IL1B 9786861 540956 Overexpression of the kinase-dead form of MKK3 or MKK6 demonstrated that either of these two mutant kinases inhibited *induced* p38 [MAPK] phosphorylation and Cox-2 expression but not JNK/SAPK phosphorylation and activation . Positive_regulation MAPK1 ITGB2 12600815 1099048 IL-3 , IL-5 , and GM-CSF could enhance p38 [MAPK] and NF-kappaB activity and *induce* ICAM-1 , CD11b , and expressions on eosinophils . Positive_regulation MAPK1 ITGB2 19502238 2115869 and CD2 *synergize* for the [Erk1/2] activation in the Natural Killer ( NK ) cell immunological synapse . Positive_regulation MAPK1 ITGB2 19843511 2203197 Furthermore , beta2 integrins modulated the capacity of isolated peritoneal macrophages to take up acetylated LDL and native LDL and to phagocytose apoptotic cells , possibly via *dependent* [mitogen activated protein kinase] signalling . Positive_regulation MAPK1 LBP 20615568 2309921 Despite activating NFkappaB , NOD1 ligand did not upregulate hepatocyte production of the acute phase proteins lipopolysaccharide binding protein , serum amyloid A , or soluble CD14 in cell culture supernatants , or upregulate mRNA expression of , serum amyloid A , C-reactive protein , or serum amyloid P . NOD2 ligand ( MDP ) did not *activate* hepatocytes when given alone , but did synergize with Toll-like receptor ligands , lipopolysaccharide (LPS) , and polyI : C to activate NFkappaB and [MAPK] . Positive_regulation MAPK1 MAP2K6 10050043 592912 In one set of experiments , we *inhibited* the activation of [MAPK] by pretreating cells with PD098059 , a specific inhibitor of ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAPK1 MAP2K6 10079106 595470 Although MKK3 , MKK4 , and all *activated* p38 [MAPk] in experimental models , only MKK3 was found to activate recombinant p38 MAPk in LPS treated neutrophils . Positive_regulation MAPK1 MAP2K6 10385412 625458 The inhibitor PD98059 , *blocked* [ERK2] activity induced by epinephrine but had no effect on the stimulation of ALP activity . Positive_regulation MAPK1 MAP2K6 10471331 641588 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Positive_regulation MAPK1 MAP2K6 10601295 574407 In addition , *activation* of p38 [MAPK] by constitutively active or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAPK1 MAP2K6 10713051 674356 Conversely , the inhibitors PD98059 and UO126 could *attenuate* EGF induced [mitogen activated protein kinase] activation , they do not affect the EGF induced mobility shift of caveolin-1 . Positive_regulation MAPK1 MAP2K6 10733514 678419 These results are consistent with the interpretation that *activates* ERK , [ERK2] then activates MLCK , and MLCK activates myosin . Positive_regulation MAPK1 MAP2K6 10759527 683131 These results demonstrate that a plant can phosphorylate and *activate* [MAPK] , and that Tyr phosphorylation is critical for the catalytic activity of MAPK in plants . Positive_regulation MAPK1 MAP2K6 10816593 714743 The MAPK kinase selectively *stimulates* p38 [MAPK] and confers protection against stress induced apoptosis in cardiac myocytes . Positive_regulation MAPK1 MAP2K6 10891559 711175 MAP kinases (MAPK) in both G-1 and G-5 cells were indistinguishably phosphorylated , yet *dependent* [MAPK] activation was observed only in G-5 cells . Positive_regulation MAPK1 MAP2K6 11005808 752402 A inhibitor , PD98059 , *inhibited* heat shock ERK [MAPK] activation by > 75 % . Positive_regulation MAPK1 MAP2K6 11085935 750718 Similarly , *activation* of JNK by Ad-MKK7D and [p38-MAPK] by resulted in the increased expression of PGHS-2 . Positive_regulation MAPK1 MAP2K6 11226259 788068 These data suggest that beta-arrestins function both as scaffolds to enhance cRaf-1 and dependent *activation* of [ERK2] , and as targeting proteins that direct activated ERK to specific subcellular locations . Positive_regulation MAPK1 MAP2K6 11237743 790287 The MAPK kinase ( ) inhibitor , PD98059 , *blocked* GSA stimulated [MAPK] activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Positive_regulation MAPK1 MAP2K6 11254696 794122 However , analysis of the dynamics of ERK2 and MEK suggested that both of them rapidly shuttle between the cytoplasm and the nucleus and that *regulates* the nuclear shuttling of [ERK2] , whereas MEK remains mainly in the cytoplasm . Positive_regulation MAPK1 MAP2K6 11304531 826821 The *activation* of p38 [MAPK] by Galpha ( q ) and Gbetagamma was blocked by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Positive_regulation MAPK1 MAP2K6 11404250 825249 The activation of [ERK2] was completely blocked either by a dominant negative Ras mutant or in the *presence* of a ( MEK ) inhibitor . Positive_regulation MAPK1 MAP2K6 11483651 844472 The inhibitors of 1/2 ( MEK1/2 ) activation , PD98059 ( 0.1-50 microM ) and UO126 ( 0.1-10 microM ) , dose-dependently *inhibited* both [ERK2] and Ser31 phosphorylation on TOH in response to AII , suggesting MEK1/2 involvement . Positive_regulation MAPK1 MAP2K6 11683493 874380 Retinoic acid ( RA ) is known to cause the myeloid differentiation of HL-60 human myeloblastic leukemia cells in a process requiring dependent [ERK2] *activation* . Positive_regulation MAPK1 MAP2K6 11787422 891909 Indeed the MAPK kinase ( = ) inhibitor PD98059 *inhibits* the activation of parasite [MAPK] , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Positive_regulation MAPK1 MAP2K6 11822870 909037 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of [MAPK] pathway *inhibitors* ( inhibitors PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAPK1 MAP2K6 12009309 940795 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Positive_regulation MAPK1 MAP2K6 12197778 981936 Although inhibition *prevented* S-1-P activation of ERK1 and [ERK2] and slightly but significantly inhibited basal Caco-2 proliferation , MEK inhibition did not block the S-1-P mitogenic effect . Positive_regulation MAPK1 MAP2K6 12203369 983201 Furthermore , PKC inhibitors or an inhibitor completely *suppressed* both TPA induced activation of [MAPK] and promotion of anchorage independent growth , but a cPKC-selective inhibitor partially suppressed TPA induced promotion of the growth . Positive_regulation MAPK1 MAP2K6 12356282 993824 IL-1beta induced p44/42 [mitogen activated protein kinase (MAPK)] activation was *inhibited* by the MAPK/extracellular signal regulated protein kinase ( ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK1 MAP2K6 12377770 1019980 These results suggest that MKK3 , rather than , *mediates* alphav integrin induced p38 [MAPK] activation . Positive_regulation MAPK1 MAP2K6 12450322 1018619 ANG II significantly increased aldosterone release , and this effect was inhibited by the LO inhibitor baicalein , as well as a specific p38 [MAPK] *inhibitor* , SB202190 , but not by PD098059 , a specific inhibitor of the ERK activator . Positive_regulation MAPK1 MAP2K6 12637559 1085446 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Positive_regulation MAPK1 MAP2K6 12659851 1073491 MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a ( MAP2K ) , which in turn *activates* a [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK1 MAP2K6 12663469 1074481 Collectively , our study indicates that a glucose induced rise in [ Ca ( 2+ ) ] ( i ) leads to cAMP induced activation of PKA that acts downstream of Ras and upstream of the MAP/Erk kinase , , to *mediate* [Erk-1/2] phosphorylation via phosphorylation activation of Raf-1 . Positive_regulation MAPK1 MAP2K6 12845643 1108571 Finally , both ODQ and UO126 blocked the capacity of L-arginine to restore ERK ( 1/2 ) phosphorylation in L-NAME treated cells , demonstrating that GC and are both *required* for endogenous NO-mediated [MAPK] activation . Positive_regulation MAPK1 MAP2K6 15019950 1221024 Phosphorylation of [Erk2] , induced by NT3 , was *reduced* by inhibition but unaffected by BMP signaling . Positive_regulation MAPK1 MAP2K6 15104236 1240283 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( ) inhibitor , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAPK1 MAP2K6 15172888 1288360 Importantly , the presence of inhibitors only at the time of the transport assay markedly *impaired* both insulin stimulated glucose uptake and [MAPK] signaling . Positive_regulation MAPK1 MAP2K6 15172888 1288462 Conversely , removal of inhibitors before the transport assay *restored* glucose uptake and [MAPK] signaling . Positive_regulation MAPK1 MAP2K6 15304546 1322489 Furthermore , *activation* of [ERK/MAPK] by the coexpression of constitutively active predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAPK1 MAP2K6 15365248 1294547 Treatment of keratinocytes with PD98059 , inhibitor , and SB20358 , p38 [MAPK] *inhibitor* , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAPK1 MAP2K6 15570612 1355543 Although the inhibitors *suppressed* [MAPK] phosphorylation in both OA- and AICAR treated oocytes , meiotic resumption was not causally linked to MAPK phosphorylation in either group . Positive_regulation MAPK1 MAP2K6 15867183 1404239 In cultured cardiac myocytes , specific *activation* of stress activated [mitogen activated protein kinase] , p38 , by upstream activator led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAPK1 MAP2K6 15879307 1411354 Conversely , constitutively active *induced* p38 [MAPK] activation that recapitulated the effects of polyphenols by inducing ERalpha phosphorylation and downstream activation of Akt , and eNOS . Positive_regulation MAPK1 MAP2K6 16157033 1455739 SB203580 , a [P38MAPK] *inhibitor* , and U0126 , a inhibitor , both completely blocked ADM mediated responses in MsC . Positive_regulation MAPK1 MAP2K6 16176063 1457747 The LPA induced phosphorylation of [ERK 1/2] and CREB was *blocked* by inhibition of PI3K , PKC and , but that of Akt was only inhibited by wortmannin , the PI3K inhibitor . Positive_regulation MAPK1 MAP2K6 16892039 1597103 *dependent* Erk1 and [Erk2] ( hereafter referred to as Erk1/2 ) signaling is identified as a downstream target of M. leprae induced ErbB2 activation that mediates demyelination . Positive_regulation MAPK1 MAP2K6 17416211 1777853 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK1 MAP2K6 18212269 1870856 A 1/2 inhibitor *inhibited* both renin and prorenin induced [ERK 1/2] phosphorylation . Positive_regulation MAPK1 MAP2K6 18401006 1925798 CyaA enhanced LPS induced phosphorylation of p38 [MAPK] and ERK in DC , and inhibitors of p38 MAPK , , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation MAPK1 MAP2K6 18754769 1968415 ( MKK) 3 and 6 are the main p38 [mitogen activated protein kinase] *activators* in mammals . Positive_regulation MAPK1 MAP2K6 18771907 1962660 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a inhibitor , and SB203580 , an *inhibitor* of p38 [mitogen activated protein (MAP) kinase] , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAPK1 MAP2K6 21557297 2464110 Pharmacologic inhibition of EGFR , , and PI3K kinase activity in SCC10A *reduced* phosphorylated levels of [ERK-1/2] and AKT , production of MMP-9 and sE-cad , cell migration and invasion , and expressional changes of EMT markers ( E-cadherin and N-cadherin ) induced by EGF , indicating that EGFR activation promotes cell migration and invasion via ERK-1/2 and PI3K regulated MMP-9/E-cadherin signaling pathways . Positive_regulation MAPK1 MAP2K6 21892182 2491659 Further , we show that *activation* of p38 [MAPK] by expression of constitutively active ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAPK1 MAP2K6 22164285 2517907 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of and marked *activation* of p38 [MAPK] . Positive_regulation MAPK1 MAP2K6 22785235 2691873 TRH induced CRE promoter was inhibited by [mitogen activated protein kinase/ERK] kinase ( MEK ) inhibitor and was *increased* by overexpression of . Positive_regulation MAPK1 MAP2K6 7541116 310274 then *activates* [p42mapk] and ( at least in mammals ) p44mapk , members of the mitogen activated protein (MAP) kinase family . Positive_regulation MAPK1 MAP2K6 7644477 318644 Inhibition of by PD 098059 *prevented* activation of [MAPK] and subsequent phosphorylation of MAPK substrates both in vitro and in intact cells . Positive_regulation MAPK1 MAP2K6 7822248 285577 ( MKK ) phosphorylates and *activates* [mitogen activated protein kinase (MAPK)] in response to stimulation of various eukaryotic signaling pathways . Positive_regulation MAPK1 MAP2K6 7889302 289421 2. Both nucleotides stimulate phosphorylation and *activation* of [mitogen activated protein kinase] and a biphasic phosphorylation of the up-stream . Positive_regulation MAPK1 MAP2K6 8180183 256221 This stimulation of the activator was temporally *followed* by increased activities of MEK and [MAPK] . Positive_regulation MAPK1 MAP2K6 8226933 235392 *Activation* of extracellular signal regulated kinase ( ERK ) or [mitogen activated protein kinase] by ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAPK1 MAP2K6 8394352 228222 We show that a similar activity phosphorylates and *activates* [MAPK] in both growth factor stimulated ( epidermal growth factor and thrombin ) and oncogene ( gip2 , v-src , and v-raf ) -transfected cells . Positive_regulation MAPK1 MAP2K6 8550616 346646 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Positive_regulation MAPK1 MAP2K6 8662760 367276 Stimulation of transfected cells with fMLP resulted in the time- and dose dependent increase in tyrosine phosphorylation and activation of ERK1 and [ERK2] and the *activation* of , the MAP kinase/ERK kinase . Positive_regulation MAPK1 MAP2K6 8663100 368139 The [MAPK] and NHE activities induced by PMA were *inhibited* by staurosporine , a potent inhibitor for protein kinase C ( PKC ) , and by MAPK kinase ( ) inhibitor , PD98059 , but were not affected by the tyrosine kinase inhibitor genistein . Positive_regulation MAPK1 MAP2K6 8663100 368231 In contrast , both AVP induced [MAPK] and NHE activities were *inhibited* by genistein and inhibitor but were not affected by staurosporine . Positive_regulation MAPK1 MAP2K6 8816498 384276 *activates* [mitogen activated protein kinase (MAPK)] , which phosphorylates other kinases as well as transcription factors . Positive_regulation MAPK1 MAP2K6 9135064 427593 In addition to *dependent* [MAPK] activation , we provide evidence for MEK independent regulation of the MAPKs . Positive_regulation MAPK1 MAP2K6 9166761 432441 The first step in [MAPK] *activation* by must be the formation of a MEK x MAPK enzyme-substrate complex , followed by phosphorylation producing monophosphorylated MAPK ( pMAPK ) . Positive_regulation MAPK1 MAP2K6 9275096 450647 We show here , that in the human neuroblastoma cell line SK-N-SH , the membrane impermeable conjugated 17beta-estradiol ( E2BSA ) activates ( MAPKK or MEK ) and *induces* the phosphorylation and activation of both ERK-1 and [ERK-2] ( mitogen activated protein kinase or MAPK ) . Positive_regulation MAPK1 MAP2K6 9418190 472300 When PDBu is used as a stimulus , [extracellular regulated kinase 2 (ERK2)] is *activated* by threonine and tyrosine phosphorylation by the dual-specificity kinase . Positive_regulation MAPK1 MAP2K6 9450967 484059 In other experiments , [p42MAPK] *activation* by or by Mos inhibited Cdc2 activation by cyclin B. PD098059 , a specific inhibitor of MEK , blocked the effects of MEK ( QP ) and Mos . Positive_regulation MAPK1 MAP2K6 9626658 511865 These results indicate that *mediates* the IGF-I/insulin induced p42/ p44 [MAPK] activation . Positive_regulation MAPK1 MAP2K6 9679985 520972 G0 growth arrest and RB tumor suppressor protein hypophosphorylation ( which is typically associated with induced differentiation and G0 arrest ) , two putatively RB-regulated processes , also depended on [ERK2] *activation* by . Positive_regulation MAPK1 MAP2K6 9679985 520979 The results thus show that RA augments dependent [ERK2] *activation* that is needed for subsequent RB hypophosphorylation , cell differentiation , and G0 arrest . Positive_regulation MAPK1 MAP2K6 9804770 544422 Furthermore , NE stimulated the expression and secretion of basic fibroblast growth factor (bFGF) , which further promoted the cell survival via dependent *activation* of [Erk1/2] . Positive_regulation MAPK1 MAP2K6 9813041 546111 The inhibitor *blocked* GH-stimulated activation of MEK , phosphorylation of [ERK1/ERK2] , and MAP kinase activity in 3T3-F442A cells . Positive_regulation MAPK1 MAP2K6 9864179 582710 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of ERK , but not p38 [MAPK] , induced by G-CSF , GM-CSF , or TNF . Positive_regulation MAPK1 MMP28 16848631 1588353 However , inhibition of the transient Erk1/2 activity with a specific mitogen activated protein kinase kinase 1 ( MEK-1 ) inhibitor PD 98059 prevented subsequent hypoxia induced proliferation at 18 h. Interestingly , inhibition of general activity , using either doxycycline or GM 6001 , *prevented* both transient [Erk1/2] activity and subsequent proliferation in response to hypoxia . Positive_regulation MAPK1 MMP28 17907155 1812578 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not *prevent* HGF induced [ERK-1/2] phosphorylation and NF-kappaB activity , but significantly restored HGF inhibited collagen and CTGF accumulation . Positive_regulation MAPK1 MMP7 16848631 1588313 and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 [mitogen activated protein kinase] activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MAPK1 MMP7 16848631 1588368 However , inhibition of the transient Erk1/2 activity with a specific mitogen activated protein kinase kinase 1 ( MEK-1 ) inhibitor PD 98059 prevented subsequent hypoxia induced proliferation at 18 h. Interestingly , inhibition of general activity , using either doxycycline or GM 6001 , *prevented* both transient [Erk1/2] activity and subsequent proliferation in response to hypoxia . Positive_regulation MAPK1 MMP7 17907155 1812594 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not *prevent* HGF induced [ERK-1/2] phosphorylation and NF-kappaB activity , but significantly restored HGF inhibited collagen and CTGF accumulation . Positive_regulation MAPK1 MMP7 21999204 2547381 Mesothelin enhances invasion of ovarian cancer by *inducing* through [MAPK/ERK] and JNK pathways . Positive_regulation MAPK1 MUC16 11481474 843804 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a [mitogen activated protein kinase] ( Erk 1/2 ) , and *activation* of transcription . Positive_regulation MAPK1 PECAM1 18029285 1866918 In contrast , expression of Delta15 in PECAM-1-/- bEND cells *had* minimal effects on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Positive_regulation MAPK1 PGC 22105890 2599538 Our studies also revealed that overexpression of in cardiomyocytes *inhibited* basal and T3-induced p38 [MAPK] phosphorylation . Positive_regulation MAPK1 PIGR 20450283 2257144 Induction of expression in HT-29 cells *required* NF-kappaB signaling but not [MAPK] signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation MAPK1 PLAT 15625301 1362091 In a mouse model of focal cerebral ischemia , *induces* eNOS inhibition , [ERK-2] activation , and p38 inhibition , possibly as part of a more complex signaling response exacerbating brain injury . Positive_regulation MAPK1 PLAT 19436314 2107035 cerebrospinal fluid and brain parenchymal ERK [MAPK] was elevated by H/I and this upregulation was *potentiated* by , but blunted by RBC-tPA . Positive_regulation MAPK1 PLAT 21037505 2499491 Red blood blocked c-Jun-N-terminal kinase but *potentiated* p38 [mitogen activated protein kinase] upregulation after photothrombotic injury . Positive_regulation MAPK1 PLAU 10766865 684601 surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha [mitogen activated protein kinase] activity . Positive_regulation MAPK1 PLAU 15031204 1257165 In HeLa cells the dominant negative form of JNK interferes with the p42/p44 [MAPK] *activation* of the . Positive_regulation MAPK1 PLAU 15874933 1405694 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 [MAPK] , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Positive_regulation MAPK1 PLAU 15874933 1405727 Although *induced* phosphorylation of both ERK1/2 and p38 [MAPK] was blocked by Galphai inhibition , inhibition of PI3K and Ras decreased the uPA induced phosphorylation of ERK1/2 but not p38 MAPK . Positive_regulation MAPK1 PLAU 18656457 1960560 Exogenous administered at 4 h post H/I further *stimulated* ERK [MAPK] phosphorylation , which was blocked by RAP . Positive_regulation MAPK1 PLAU 9660790 517495 The receptor *mediates* tyrosine phosphorylation of focal adhesion proteins and activation of [mitogen activated protein kinase] in cultured endothelial cells . Positive_regulation MAPK1 PLAU 9660790 517508 The induced *activation* of [MAPK] was completely inhibited by genistein , but not by 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo [ 3 , 4-d ] pyrimidine , a specific inhibitor of Src family kinases . Positive_regulation MAPK1 PODXL 17616675 1769269 expression also *led* to an increase in [mitogen activated protein kinase (MAPK)] and phosphatidylinositol 3-kinase (PI3K) activity . Positive_regulation MAPK1 PODXL 17616675 1769316 These findings suggest that leads to increased in vitro migration and invasion , increased MMP expression , and *increased* activation of [MAPK] and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MAPK1 PTGER2 19233324 2072055 Further , PGE ( 2 ) , EP2A and EP4A did not increase BMP2/4 mRNA levels in RC cells , and *induced* phosphorylation of p38 [MAPK] was not eliminated by Noggin . Positive_regulation MAPK1 RASD1 11751935 921985 Expression of alone *resulted* in a 1.9- to 4.9-fold increase in [HA-Erk-2] activity ; Positive_regulation MAPK1 RGS2 18398336 1893706 Silencing in BS/GS patients *increased* Ang II-induced Cai2+ release and [ERK 1/2] phosphorylation in silenced cells compared with not silenced cells [ 59.3 +/- 10.8 ( peak-basal ) vs. 40.5 +/- 14.1 nmol/l , P = 0.017 and 0.84 +/- 0.06 vs. 0.64 +/- 0.08 nmol/l , P < 0.03 , respectively ] , whereas they were not different compared with controls ( 60.1 +/- 4.3 and 0.91 +/- 0.03 nmol/l ) . Positive_regulation MAPK1 SLC38A3 15331357 1287997 In contrast , *stimulated* [MAPK] activation was blocked by > 80 % by dominant negative Ras but not by dominant negative Rho and Cdc42 . Positive_regulation MAPK1 SNCAIP 12639553 1068699 In addition , [MAPK] was *activated* by through Edg-1 , Sph-1-P receptor . Positive_regulation MAPK1 SPHK1 18602364 1941496 As a result , inhibition of by SKI *blocked* phosphorylation of p38 [MAPK] , showing that SPHK activation by IL-18 is an upstream signal of p38 MAPK activation . Positive_regulation MAPK1 SPHK1 22684547 2705930 *increased* the constitutive expression of [extracellular signal regulated kinase1/2] ( ERK1/2 ) but reduced the constitutive expression of p38 mitogen activated protein kinase (MAPK) . Positive_regulation MAPK1 STK39 17237610 1690211 The phosphorylation of cytoplasmic p38 [MAPK] in Akata cells was *reduced* by the inhibitor , 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperazine ( H7 ) . Positive_regulation MAPK1 TFPI2 18703135 1961387 Overexpression of PP2A or partially *prevented* Cd-induced activation of [Erk1/2] and JNK , as well as cell death . Positive_regulation MAPK1 TFPI2 22298641 2580282 Overexpression of PP2A or partially *prevented* curcumin induced activation of JNK and [Erk1/2] phosphorylation as well as cell death . Positive_regulation MAPK1 TLR7 16424221 1515525 MKP-1-deficient macrophages also show enhanced constitutive and induced *activation* of p38 [MAPK] . Positive_regulation MAPK1 TLR7 18287072 1872534 However , when coupled with Sema6D , a ligand for Plexin-A1 , limited *resulted* in PDC-TREM mediated DAP12 dependent phosphorylation of phosphoinositide 3-kinase (PI3K) and [extracellular regulated kinase (Erk) 1/2] at 6-9 h , and IFN-alpha was produced . Positive_regulation MAPK1 TLR7 23979601 2850605 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Positive_regulation MAPK1 TLR7 24404585 2884115 Together , our finding shows that in addition to the *mediated* TPL2 activation of [ERK1/ERK2] , an additional pathway contributing to ERK1/ERK2 activation is triggered by infection of CF AECs : the EGFR signaling pathway . Positive_regulation MAPK1 TLR7 24879442 2940956 GIT2 terminates *induced* NF-?B and [MAPK] signaling by recruiting the deubiquitinating enzyme Cylindromatosis to inhibit the ubiquitination of TRAF6 . Positive_regulation MAPK1 TNF 10201904 605669 *induced* tyrosine phosphorylation and enzymatic activation of [ERK2] , SAPK/JNK , and p38mapk , whereas IL-10 did not induce these events . Positive_regulation MAPK1 TNF 10504489 648978 Pretreatment with SB203580 ( 10 microM ) had no effect on basal or TNF-alpha stimulated phosphorylation of p38 MAPK but completely abolished *stimulated* p38 [MAPK] activity . Positive_regulation MAPK1 TNF 10521481 653108 The study presented here shows that autoregulation of gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 [mitogen activated protein (MAP) kinase] activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation MAPK1 TNF 10559258 566515 Kinase-defective point and deletion variants of RIP2 also significantly blocked the *activation* of [ERK2] by but not epidermal growth factor . Positive_regulation MAPK1 TNF 10570180 568156 Furthermore , LPS , UV irradiation , and *caused* activation of p38 [MAPK] whereas IFN-gamma did not . Positive_regulation MAPK1 TNF 10601128 574191 alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation MAPK1 TNF 10640438 577495 IL-1 beta and also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK1 TNF 10669634 665803 In this study , we show that *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation MAPK1 TNF 10753884 682338 Moreover , *stimulated* both the NF-kappaB and [mitogen activated protein (MAP) kinase] ( extracellular signal regulated kinase , c-Jun NH ( 2 ) -terminal kinase , and p38 MAP kinase ) signaling pathways in astrocytes . Positive_regulation MAPK1 TNF 10783388 707845 *dependent* p38 [MAPK] activation was detected in both Mo7e and Hut-78 cells and was blocked by the p38 MAPK inhibitor , SB203580 . Positive_regulation MAPK1 TNF 10783388 707898 SB203580 did not affect TNF-alpha signaled nuclear translocation and DNA binding activity of NF-kappaB , and inhibition of NF-kappaB function did not affect induced p38 [MAPK] *activation* , indicating that these events are not dependent on each other . Positive_regulation MAPK1 TNF 10864897 705717 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK1 TNF 10864897 705769 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by and IL-1beta . Positive_regulation MAPK1 TNF 11067939 747581 CPPD crystals were observed to *induce* a robust and transient activation of ERK1 , [ERK2] , and Akt , whereas produced only a modest and delayed activation of Akt . Positive_regulation MAPK1 TNF 11095634 755295 rapidly *activated* [MAPK] and increased the extent of attachment , spreading and migration on fibronectin and collagen type I ( P < 0.01 ) but not on collagen type IV . Positive_regulation MAPK1 TNF 11108246 756724 *activates* extracellular regulated kinase-1/2 ( ERK1/2 ) and [p38MAPK] . Positive_regulation MAPK1 TNF 11108836 757035 In RAW264 cells which differentiate into osteoclast-like multinucleated cells by TNF treatment alone , activation of p38 [mitogen activated protein (MAP) kinase] *induced* by murine was comparable to and independent of the receptor activator of necrosis factor-kappaB ligand . Positive_regulation MAPK1 TNF 11156586 780611 1. We have previously shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce interleukin-8 (IL-8) by human pulmonary vascular endothelial cells . Positive_regulation MAPK1 TNF 11167962 783062 It has previously been shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce cytokine , including RANTES , that N-acetylcysteine (NAC) attenuates cytokine production by human bronchial epithelial cells ( BECs ) , and that sensitivity to TNFalpha is inversely correlated with cellular redox state . Positive_regulation MAPK1 TNF 11221891 787467 To determine the role of KSR in *induced* [ERK1/ERK2] activation , we studied young adult mouse colon cells expressing a dominant negative , kinase-inactive ( ki ) KSR . Positive_regulation MAPK1 TNF 11221891 787477 We therefore conclude that KSR is an essential upstream regulator of *stimulated* [ERK1/ERK2] activation , most likely mediated via direct phosphorylation of Raf-1 . Positive_regulation MAPK1 TNF 11266661 797165 However , *caused* no activation of p42/p44 [MAPK] or cytosolic phospholipase A(2) activity . Positive_regulation MAPK1 TNF 11277995 798107 *activates* extracellular regulated kinases ( ERKs ) and p38 [mitogen activated protein kinase] ( p38MAPK ) , and inhibits the expression of uncoupling protein-1 (UCP-1) and adipocyte-specific genes in rat fetal brown adipocytes . Positive_regulation MAPK1 TNF 11319753 806835 SB 203580 , a selective inhibitor of p38 MAPK , inhibited IL-1 and *induced* p38 [MAPK] activity and IL-6 production ( IC ( 50 ) s 0.3 -- 0.5 microM ) in osteoblasts and chondrocytes . Positive_regulation MAPK1 TNF 11319753 806850 In addition , IL-1 and also *activated* p38 [MAPK] in fetal rat long bones and p38 MAPK inhibitors inhibited IL-1- and TNF stimulated bone resorption in vitro in a dose dependent manner ( IC ( 50 ) s 0.3 -- 1 microM ) . Positive_regulation MAPK1 TNF 11435466 832525 However , the cytotoxic responses to daunorubicin and exogenous ceramide remain unaltered , as do the *induced* p42/p44 [MAPK] activation and CD54 expression . Positive_regulation MAPK1 TNF 11438547 843390 *activated* p38 [MAPK] and p44/p42 MAPK in wild-type but not in p60 ( -/- ) , p80 ( -/- ) , or p60 ( -/- ) p80 ( -/- ) macrophages . Positive_regulation MAPK1 TNF 11489936 845475 Early [Erk1/2] activation was stimulated directly by SDF-1 alpha and late activation was *mediated* by . Positive_regulation MAPK1 TNF 11494147 846169 In this study we demonstrate that *triggers* only modest proliferation , as well as p44/p42 [mitogen activated protein kinase (MAPK)] and NF-kappaB activation , in MM.1S multiple myeloma ( MM ) cells . Positive_regulation MAPK1 TNF 11495721 846384 Furthermore , overexpression of dominant negative mutants , H-Ras-15A and Raf-N4 , significantly suppressed p42/p44 [mitogen activated protein kinase (MAPK)] activation *induced* by and PDGF-BB and attenuated the effect of TNF-alpha on BK-induced IP response , indicating that Ras and Raf may be required for activation of these kinases . Positive_regulation MAPK1 TNF 11509550 848348 Although IL-1 beta and each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK1 TNF 11592111 869653 Lipopolysaccharide (LPS) treatment of a microglial cell line ( N9 ) *induced* a time dependent activation of both p38 mitogen activated protein kinase ( p38 [MAPK] ) and nuclear factor-kappaB (NFkappaB) , with consequent increases in interleukin-1alpha (IL-1alpha) , , and nitric oxide ( NO ) production . Positive_regulation MAPK1 TNF 11689211 876134 Potential nuclear targets of *activated* [ERK 1/2] include the transcription factors Ets-1 , Egr-1 , and c-fos , which are known to regulate cellular growth , differentiation , and migration . Positive_regulation MAPK1 TNF 11689211 876145 *induced* [ERK 1/2] activation in both cell types . Positive_regulation MAPK1 TNF 11694522 896410 *activated* the three mammalian [MAPK] , p44/42 , JNK , and p38 , in a distinct time- and concentration dependent manner . Positive_regulation MAPK1 TNF 11694522 896436 In conclusion , although *activates* all three known [MAPK] in human preadipocytes , only p44/42 and JNK appear to be involved in the regulation of lipolysis . Positive_regulation MAPK1 TNF 11750919 898168 Biochemical and immunocytochemical analysis showed that *activated* p38 mitogen activated protein kinase ( p38MAPK ) and c-Jun N-terminal kinase (JNK) but not p42/p44 [MAPK] . Positive_regulation MAPK1 TNF 11820362 908735 *activated* p38 [MAPK] and stimulated IL-6 secretion by MG-63 cells , and pre-incubation of cells with the p38 MAPK inhibitor abrogated TNF-alpha dependent IL-6 secretion . Positive_regulation MAPK1 TNF 11820362 908764 Transfection of IL-6 full-length and 5-deletion gene promoter reporter constructs indicated that p38 [MAPK] *activation* by enhanced IL-6 gene expression , and that the p38 MAPK-responsive region resided in the proximal 260-bp segment . Positive_regulation MAPK1 TNF 11820362 908800 In conclusion , although p38 [MAPK] *activation* by stimulates IL-6 secretion by MG-63 cells , it has opposing effects on c/EBPbeta and NFkappaB activity . Positive_regulation MAPK1 TNF 11930247 927415 The p44/42 [MAPK] activity was significantly *enhanced* by and the TNF-alpha effect was opposed by rhIL-10 . Positive_regulation MAPK1 TNF 11930247 927428 It is suggested that rhIL-10 can inhibit *induced* VSMC proliferation and phosphorylation of p44/42 [MAPK] . Positive_regulation MAPK1 TNF 12095140 960561 significantly increased permeability and *induced* p38 and ERK [MAPK] activation compared with controls ( P < 0.05 ) . Positive_regulation MAPK1 TNF 12114204 963991 *increased* the phosphorylation of p38 MAPK within 15 min. Anisomycin , an activator of p38 MAPK , increased p38 [MAPK] phosphorylation and decreased SP-A mRNA levels in a dose dependent manner . Positive_regulation MAPK1 TNF 12130576 966572 Phosphorylation of p38 [MAPK] was *induced* by RANKL , IL-1 , , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation MAPK1 TNF 12131776 966850 IL-1 beta and *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK1 TNF 12297009 991034 In this study , we examined the anti-apoptotic role of p38 [MAPK] that is *activated* by in neuronal PC12 cells . Positive_regulation MAPK1 TNF 12297009 991047 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Positive_regulation MAPK1 TNF 12393915 1025427 This model probiotic also inhibits *activation* of the pro-apoptotic [p38/mitogen activated protein kinase] by , interleukin-1alpha , or gamma-interferon . Positive_regulation MAPK1 TNF 12483539 1024797 In addition , PP1 substantially inhibited the IL-2beta- and dependent *activation* of [Erk 1/2] and Akt . Positive_regulation MAPK1 TNF 12511413 1079025 The treatment of RAW264 cells with TSA and NaB inhibited *induced* nuclear translocation of NF-kappa B and sRANKL induced activation of p38 [mitogen activated protein kinase (MAPK)] signals . Positive_regulation MAPK1 TNF 12526087 1028232 does not *induce* phosphorylation of [ERK1/ERK2] and S727 in ECV304 and smooth muscle cells . Positive_regulation MAPK1 TNF 12631113 1067612 Additional experiments examining the role of cAMP on MC fractalkine expression showed that the incubation of MCs with TNF-alpha and either db-cAMP or forskolin attenuated TNF-alpha stimulated fractalkine mRNA and protein expression , preceded by attenuation of *activated* phosphorylation of p42/44 [MAPK] , and c-Jun , but not phosphorylation of PKCzeta/iota or nuclear translocation of NF-kappaB . Positive_regulation MAPK1 TNF 12637577 1099296 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and *requires* p38 [MAPK] activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation MAPK1 TNF 12665666 1030367 This study was undertaken to examine the relationship between induced cardiomyocyte apoptosis and *activation* of p38 [mitogen activated protein kinase (MAPK)] through oxidative stress . Positive_regulation MAPK1 TNF 12665666 1030380 Corresponding to the apoptotic effect , at 10 ng/mL *caused* rapid phosphorylation of p38 [MAPK] in wild-type cardiomyocytes . Positive_regulation MAPK1 TNF 12694807 1080906 *induced* the phosphorylation of p44/p42 [mitogen activated protein (MAP) kinase] and p38 MAP kinase . Positive_regulation MAPK1 TNF 12731668 1086842 On the other hand , GM-CSF- or *induced* phosphorylation of ERK and p38 [MAPK] was unaffected by these inhibitors at the concentrations effective for the inhibition of O2- release and adherence . Positive_regulation MAPK1 TNF 12829618 1113801 However , *induced* [p38-MAPK] phosphorylation was markedly diminished in mkk3-/- vs mkk3+/+ hearts ( percent basal , 127+/-23 versus 540+/-267 , respectively , P=0.04 ) , suggesting an MKK independent activation mechanism by ischemia . Positive_regulation MAPK1 TNF 12844496 1149725 Rho inhibition decreases *induced* endothelial [MAPK] activation and monolayer permeability . Positive_regulation MAPK1 TNF 12844496 1149738 Because GTP binding proteins have been implicated in MAPK activation , we now hypothesize that the GTP binding protein Rho is a mediator of *induced* [MAPK] activation and increased endothelial permeability . Positive_regulation MAPK1 TNF 12844496 1149752 C3 transferase attenuated induced [MAPK] *activation* and blocked TNF induced endothelial permeability . Positive_regulation MAPK1 TNF 12867430 1141968 Subsequently , mediated p38 [MAPK] *activation* induced sialidase activity and CD44-HA binding . Positive_regulation MAPK1 TNF 12867430 1142102 Taken together , our results suggest that *induced* p38 [MAPK] activation may regulate the induction of functionally active HA-binding form of CD44 by activating sialidase in LPS stimulated human monocytic cells . Positive_regulation MAPK1 TNF 12881424 1116127 Importantly , does not *induce* ROS accumulation or prolonged [MAPK] activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death Positive_regulation MAPK1 TNF 12893778 1121025 We show that MKK3 and MKK6are essential for *stimulated* p38 [MAPK] activation . Positive_regulation MAPK1 TNF 12960255 1158283 To investigate a potential interplay between induced *activation* of p38 [MAPK] and NF-kappaB , the p38 MAPK inhibitor SB203580 and a dominant negative p38 MAPK mutant were used . Positive_regulation MAPK1 TNF 14516792 1147199 [MAPK] pathway *activation* via was confirmed by marked AP-1 activation detected in EMSA . Positive_regulation MAPK1 TNF 14561851 1165101 In cultured human umbilical vein endothelial cells ( HUVECs ) , and lipopolysaccharide *increased* phosphorylation of p38 [MAPK] ( P-p38 MAPK ) and increased ICAM-1 expression . Positive_regulation MAPK1 TNF 14592823 1209460 Analyzing the individual contribution of PF-4 and its costimuli in the control of these functions at the signaling level , we demonstrate that induced *activation* of p38 [mitogen activated protein (MAP) kinase] ( but not extracellular regulated kinase [ Erk ] kinases ) acts as general and essential costimulatory signal in PF-4 dependent neutrophil exocytosis . Positive_regulation MAPK1 TNF 14632659 1170646 *activated* p38 [MAPK] in DCs only at an early time-point ( 15 min ) . Positive_regulation MAPK1 TNF 14654378 1176824 These findings suggest that the pre-ischemic *activation* of [p38-MAPK] by does not contribute to cardioprotection afforded by this agent . Positive_regulation MAPK1 TNF 15002040 1265072 Consistent with the abrogation of osteoclastogenic effect of DcR3 by TNFR-Fc , DcR3 treatment can *induce* osteoclastogenic cytokine release through ERK and p38 [MAPK] signaling pathways . Positive_regulation MAPK1 TNF 15087472 1258134 Stimulatory effects of on neuropeptide gene expression and release appeared to be mediated through the type 2 TNF-alpha receptor , and *required* activation of [ERK 1/2] and p38 , but not Janus kinase , MAPKs . Positive_regulation MAPK1 TNF 15139014 1246953 The increase in release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not [mitogen activated protein kinase (MAPK)] , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation MAPK1 TNF 15191888 1295235 Treatment of endothelial cells with SphK1 siRNA suppressed *induced* increase in MCP-1 mRNA levels , MCP-1 protein secretion , and activation of p38 [MAPK] . Positive_regulation MAPK1 TNF 15212763 1262308 Interestingly , Ad5NIK , but not , *induces* RelA S536 and p38 [mitogen activated protein kinase (MAPK)] phosphorylation in IKKgamma ( -/- ) cells . Positive_regulation MAPK1 TNF 15233873 1269386 A. semen also inhibited the expression of and the *activation* of [mitogen activated protein kinase] , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation MAPK1 TNF 15240695 1270278 TNF activates Syk protein tyrosine kinase leading to induced [MAPK] *activation* , NF-kappaB activation , and apoptosis . Positive_regulation MAPK1 TNF 15240695 1270298 TNF induced Syk activation was abolished by piceatannol ( Syk-selective inhibitor ) , which led to the suppression of induced *activation* of c- JNK , p38 MAPK , and p44/p42 [MAPK] . Positive_regulation MAPK1 TNF 15240695 1270314 Jurkat cells that did not express Syk ( JCaM1 , JCaM1/lck ) showed lack of *induced* Syk , JNK , p38 [MAPK] , and p44/p42 MAPK activation , as well as TNF induced IkappaBalpha phosphorylation , IkappaBalpha degradation , and NF-kappaB activation . Positive_regulation MAPK1 TNF 15240695 1270345 Overall , our results demonstrate that Syk activation plays an essential role in induced *activation* of JNK , p38 [MAPK] , p44/p42 MAPK , NF-kappaB , and apoptosis . Positive_regulation MAPK1 TNF 15240725 1270453 p38 [MAPK] was *activated* by and oxidants in nonadherent conditions i.e. , with 10 mM EDTA . Positive_regulation MAPK1 TNF 15240725 1270467 Finally , p38 [MAPK] *activation* by was blocked by diphenylene iodonium , an inhibitor of flavoprotein oxidoreductase , and by the free radical scavenger N-acetylcystein . Positive_regulation MAPK1 TNF 15265936 1275729 Besides NF-kappa B , celecoxib also suppressed *induced* JNK , p38 [MAPK] , and ERK activation . Positive_regulation MAPK1 TNF 15290420 1278546 Halothane or isoflurane augmented the LPS- and *induced* activation of p38 [MAPK] . Positive_regulation MAPK1 TNF 15304089 1284475 DNCB , NiSO ( 4 ) and *activated* p38 [mitogen activated protein kinases (MAPK)] and c-jun N-terminal kinase ( JNK ) . Positive_regulation MAPK1 TNF 15322069 1333417 We have also investigated the phosphorylation of p42/44 [MAPK] and *upregulation* of RhoA protein by . Positive_regulation MAPK1 TNF 15452110 1341988 In contrast , *induced* p42/p44 [MAPK] activation and CD54 expression remained unaltered . Positive_regulation MAPK1 TNF 15589482 1356208 In addition , luteolin inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , IkappaB degradation , and NF-kappaB activation . Positive_regulation MAPK1 TNF 15659876 1350298 The anabolic effect of was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an extracellular regulated kinases (ERK) . Positive_regulation MAPK1 TNF 15696169 1372152 Using TCPTP-deficient fibroblasts , we show here that TCPTP regulates *induced* [MAPK] but not NF-kappaB signaling . Positive_regulation MAPK1 TNF 15696169 1372197 These results link TCPTP and Src tyrosine kinases to the selective regulation of *induced* [MAPK] signaling and identify a previously unknown mechanism for modulating inflammatory responses mediated by TNF . Positive_regulation MAPK1 TNF 15703956 1497464 *Activation* of p38 [mitogen activated protein (MAP) kinase] and phosphatidylinositol 3-kinase (PI3K) by was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation MAPK1 TNF 15792609 1386790 By stimulation of in AM-1 cells , the phosphorylation of Akt ( Ser473 ) and p44/42 [mitogen activated protein kinase (MAPK)] ( Thr202/Tyr204 ) was markedly *increased* in TNFalpha concentration and time dependent manner . Positive_regulation MAPK1 TNF 15792609 1386803 Pretreatment with U0126 , mitogen activated extracellular regulated kinase ( MEK) 1/2 inhibitor , prior to TNFalpha stimulation , specifically inhibited *induced* phosphorylation of p44/42 [MAPK] ( Thr202/Tyr204 ) in AM-1 cells . Positive_regulation MAPK1 TNF 15792609 1386819 Meanwhile , pretreatment with LY294002 , phosphatidylinositol-3-OH kinase (PI3K) inhibitor , could inhibit both *induced* phosphorylation of Akt ( Ser473 ) and p44/42 [MAPK] ( Thr202/Tyr204 ) . Positive_regulation MAPK1 TNF 15823554 1393908 Furthermore , potently *activated* p38 [MAPK] , JNK , and NF-kappaB . Positive_regulation MAPK1 TNF 15837794 1432545 Expression of this protein inhibited induced *activation* of NFkappaB , JNK , and p38 [MAPK] and sensitized the cells to TNF induced apoptosis . Positive_regulation MAPK1 TNF 15845648 1425543 *induces* a more than tenfold increase in p38 [mitogen activated protein kinase (MAPK)] but not extracellular signal regulated kinase phosphorylation . Positive_regulation MAPK1 TNF 15870903 1405543 In addition , GA inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , I kappa B alpha degradation , and NF-kappa B activation . Positive_regulation MAPK1 TNF 15979106 1459097 The involvement of this nucleoside in the *activation* of [ERK 1/2] by was also investigated . Positive_regulation MAPK1 TNF 16009485 1441395 Moreover , p44/42 [mitogen activated protein kinase] appears to partly *mediate* the negative effect of insulin but not on ATGL . Positive_regulation MAPK1 TNF 16023081 1441584 Ellagic acid inhibited IL-1beta- and induced *activation* of activator protein-1 and mitogen activated protein kinases ( extracellular signal regulated kinase , c-Jun N-terminal kinase and p38 [mitogen activated protein kinase] ) , but not of nuclear factor-kappaB . Positive_regulation MAPK1 TNF 16025396 1435607 *activated* the phosphorylation of p44/42 [MAPK] , p38 MAPK , SAPK/JNK and Akt in mesangial cells . Positive_regulation MAPK1 TNF 16025396 1435623 PGE1 inhibited the *induced* phosphorylation of SAPK/JNK and Akt , but not p44/42 MAPK and p38 [MAPK] . Positive_regulation MAPK1 TNF 16080915 1442763 Comparative gene array analysis of *induced* [MAPK] and NF-kappaB signaling pathways between retinal ganglion cells and glial cells . Positive_regulation MAPK1 TNF 16140562 1499249 These results suggested that TNFalpha induced both cell survival and apoptosis pathways in ameloblastoma and potential of TNFalpha in inducing apoptosis can be improved by inhibiting *induced* Akt and p44/42 [mitogen activated protein kinase (MAPK)] cell survival pathways . Positive_regulation MAPK1 TNF 16275991 1480292 Angiotensin II , , or epidermal growth factor *induced* [MAPK] phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation MAPK1 TNF 16291729 1526066 *Activation* of [MAPK] and Akt by anti-HER2/neu inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation MAPK1 TNF 16314440 1486995 treatment *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation in NPCs , and SB202190 , an inhibitor of p38 MAPK , blocked TNF-alpha induced chemokine production . Positive_regulation MAPK1 TNF 16325162 1511660 Furthermore , APE1/ref-1 overexpression inhibited the *induced* increase in intracellular superoxide and p38 [MAPK] phosphorylation . Positive_regulation MAPK1 TNF 16452991 1611728 Western blots showed that IL-1beta and *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK1 TNF 16517732 1530928 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of , but not IL-6 , *requires* the activity of p38 [MAPK] . Positive_regulation MAPK1 TNF 16573652 1556132 HA-mediated production *required* p38 [MAPK] , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation MAPK1 TNF 16682409 1584053 Further , the deletion of NQO1 abolished *induced* c-Jun N-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] activation . Positive_regulation MAPK1 TNF 16781693 1585611 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and and the *activation* of [MAPK] 's are potentially positive signals for IL-10 production . Positive_regulation MAPK1 TNF 16798728 1638530 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Positive_regulation MAPK1 TNF 16875982 1593558 *activates* [p38-MAPK] , a stress-responsive kinase implicated in contractile depression and cardiac injury . Positive_regulation MAPK1 TNF 16875982 1593572 Under conditions of constant coronary flow , the [p38-MAPK] activation and contractile depression *induced* by , though attenuated , remained sensitive to the absence of MKK3 or the presence of SB203580 . Positive_regulation MAPK1 TNF 16875982 1593586 *activates* [p38-MAPK] in the intact heart and in isolated cardiac myocytes through MKK3 . Positive_regulation MAPK1 TNF 16982923 1617358 Compared with wild-type cells , MIF-deficient cells were hyporesponsive to IL-1- and *induced* [MAPK] activity , AP-1 activity , and cellular proliferation , while NF-kappaB function was preserved . Positive_regulation MAPK1 TNF 17070777 1649824 Inhibition of Syk down-regulated *induced* p38 and p44/42 [MAPK] phosphorylation and nuclear translocation of p65 NF-kappaB . Positive_regulation MAPK1 TNF 17099067 1676196 Importantly , Dex is able to increase the expression of MKP-1 , which causes an inactivation of *induced* p38 [MAPK] and mediates inhibition of E-selectin expression . Positive_regulation MAPK1 TNF 17126899 1677669 Stimulation of ECs with *induced* rapid increases in the phosphorylation of their mitogen activated protein kinases ( MAPKs ) [ extracellular signal regulated kinase ( ERK ) , c-Jun-NH2-terminal kinase (JNK) , and p38 [MAPK] ] ; Positive_regulation MAPK1 TNF 17126905 1686539 Differential regulation of and GM-CSF *induced* activation of P38 [MAPK] in neutrophils and eosinophils . Positive_regulation MAPK1 TNF 17138860 1653542 The role of delta-PKC in mediated *activation* of [MAPK] is not known . Positive_regulation MAPK1 TNF 17138860 1653568 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 MAPK are involved in TNF antiapoptotic signaling and whether delta-PKC is a key regulator of [MAPK] *activation* by . Positive_regulation MAPK1 TNF 17138860 1653594 In human neutrophils , *activated* both p38 [MAPK] and ERK1/2 principally via TNFR-1 . Positive_regulation MAPK1 TNF 17158449 1694242 A green fluorescent protein fusion protein containing the last 100 residues of TAK1 ( TAK1-C100 ) abolished the interaction of endogenous TAB2/TAB3 with TAK1 , the phosphorylation of TAK1 , and prevented the activation of IKK and [MAPK] *induced* by IL-1 , , and RANKL . Positive_regulation MAPK1 TNF 17161959 1694534 Upon examination of the signaling components , we found that was a potent *activator* of p38 , p44/42 , p54/46 [MAPK] , and IkappaBalpha ( IkappaBalpha ) . Positive_regulation MAPK1 TNF 17172975 1679382 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the [MAPK] , and production of . Positive_regulation MAPK1 TNF 17172975 1679408 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the [MAPK] , and production of . Positive_regulation MAPK1 TNF 17189827 1680157 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Positive_regulation MAPK1 TNF 17202326 1680810 Augmented lipopolysaccharide induced production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK1 TNF 17202326 1680836 In this study , we show that augmented LPS induced production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK1 TNF 17218473 1732507 The RhoA inhibitor C3 exoenzyme and the ROCK inhibitor Y-27632 both attenuated induced [MAPK] *activation* and blocked AR expression in HIMEC . Positive_regulation MAPK1 TNF 17220297 1703049 TRAF2 and ASK1 play essential roles in *induced* [mitogen activated protein kinase] signaling . Positive_regulation MAPK1 TNF 17258890 1725444 The effects of and FasL on GrB expression were specifically *mediated* by [p38MAPK] ( Mitogen-activated-protein-kinase ) activation . Positive_regulation MAPK1 TNF 17425653 1748779 The percentage increases in IL-18 induced phosphorylation of extracellular signal regulated kinase ( ERK ) in Th cells of NDN and DN were significantly higher than controls ( P < 0.05 ) , while the percentage increase in *induced* phosphorylation of p38 [MAPK] in monocytes and IL-18 induced phosphorylation of p38 MAPK in Th cells and monocytes were significantly higher in NDN patients than controls . Positive_regulation MAPK1 TNF 17438131 1742765 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation MAPK1 TNF 17438336 1749071 FAK promoted *stimulated* [MAPK] activation needed for maximal IL-6 production . Positive_regulation MAPK1 TNF 17438336 1749087 Analysis of FAK ( -/- ) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity , Tyr-397 phosphorylation , and the Pro-712/713 proline-rich region of FAK were required for *stimulated* [MAPK] activation and IL-6 production . Positive_regulation MAPK1 TNF 17446186 1749506 *increased* p38 [MAPK] phosphorylation , potently stimulated IRS-1 serine phosphorylation , and blunted insulin stimulated IRS-1 tyrosine and Akt phosphorylation and eNOS activity . Positive_regulation MAPK1 TNF 17531219 1762166 On the other hand , aloe emodin did not affect *induced* activation of p38 [mitogen activated protein kinase] or generation of reactive oxygen species . Positive_regulation MAPK1 TNF 17607712 1798185 Although *induced* the activation of p38 [MAPK] , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation MAPK1 TNF 17725582 1801630 MAC inhibited *induced* p38 [mitogen activated protein kinase] activation and cell death in cultured Schwann cells . Positive_regulation MAPK1 TNF 17895408 1823961 IA did not interfere with induced *activation* of c-Jun N-terminal kinase (JNK) and p38 [mitogen activated protein kinase] . Positive_regulation MAPK1 TNF 17906365 1803234 Dexamethasone ( DEX ; 10 ( -12 ) -10 ( -4 ) M ) reduced *induced* phosphorylation of [ERK-1/-2] and prevented TNFalpha induced VEGF generation without differences between non-smokers , smokers with and without COPD . Positive_regulation MAPK1 TNF 17942934 1814210 Deletion of NQO2 also abolished induced c-Jun NH2-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] *activation* . Positive_regulation MAPK1 TNF 17994109 1851158 triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 [MAPK] , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation MAPK1 TNF 18039275 1828524 Further downstream in this axis of signalling , blockade *reduces* only acute bronchoconstriction , while [MAPK] inhibition abrogates completely endotoxin induced inflammation . Positive_regulation MAPK1 TNF 18060043 1853598 In cultures of Schwann cells , astrocytes , and microglia , sLRP-alpha inhibited *induced* activation of p38 MAPK and [ERK/MAPK] . Positive_regulation MAPK1 TNF 18060869 1846778 *stimulated* MMP-9 expression and [Erk1/2] activation were both significantly inhibited by LOX-PP. Immunohistochemistry studies carried out with affinity purified anti-LOX-PP antibody showed that LOX-PP epitopes were expressed at elevated levels in vascular lesions of injured arteries . Positive_regulation MAPK1 TNF 18061162 1861512 We demonstrate that *induced* proliferation of C4HD murine mammary tumor cells and of T47D cells through the activation of p42/p44 [MAPK] , JNK , PI3-K/Akt pathways and nuclear factor-kappa B (NF-kappa B) transcriptional activation . Positive_regulation MAPK1 TNF 18091748 1847363 *induced* phosphorylation of extracellular signal regulated kinase ( ERK ) and Akt , but not p38 [mitogen activated protein kinase (MAPK)] , was attenuated by nicardipine , cilnidipine , benidipine , efonidipine , and azelnidipine . Positive_regulation MAPK1 TNF 18227157 1884356 It was shown that these three proteins could ( i ) induce expression of and tissue factor and ( ii ) *induce* phosphorylation of p44/42 [mitogen activated protein kinases (MAPK)] and activation of early growth response factor 1 (Egr-1) . Positive_regulation MAPK1 TNF 18258304 1884792 However , over-expression of a dominant negative form of Rac strongly inhibited *induced* p42/44 [MAPK] kinase activation , but had little effect upon JNK and no effect upon p38 MAPK activity . Positive_regulation MAPK1 TNF 18287053 1872485 Here , we show that the murine CMV M45 protein binds to RIP1 and inhibits induced *activation* of NF-kappaB , p38 [MAPK] , and caspase independent cell death . Positive_regulation MAPK1 TNF 18287248 1896521 Flavopiridol suppresses *induced* activation of activator protein-1 , c-Jun N-terminal kinase , p38 [mitogen activated protein kinase (MAPK)] , p44/p42 MAPK , and Akt , inhibits expression of antiapoptotic gene products , and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells . Positive_regulation MAPK1 TNF 18314542 1931902 P < 0.05 ) , and MKP-1 up-regulation was temporally related to the inhibition of *induced* p38 [MAPK] phosphorylation . Positive_regulation MAPK1 TNF 18336852 1912236 *stimulated* phosphorylation of p42/p44 [MAPK] and JNK were attenuated by pretreatment with the inhibitors U0126 and SP600125 or transfection with dominant negative mutants of DeltaERK and DeltaJNK . Positive_regulation MAPK1 TNF 18364436 1912764 We , for the first time , demonstrate that binding of staphylococcal enterotoxin B to MHC-II results in activation of TNF-alpha converting enzyme , epidermal growth factor receptor , [p38MAPK] , and NF-kappaB *inducing* biphasic production . Positive_regulation MAPK1 TNF 18443205 1938522 Conversely , *induced* increases in insulin receptor substrate-1 serine phosphorylation ( Ser ( 312 ) ) , Jun NH ( 2 ) -terminal kinase phosphorylation , and extracellular signal related kinase-1/2 [mitogen activated protein kinase (MAPK)] phosphorylation were unaltered by siRNA mediated IKKbeta reduction . Positive_regulation MAPK1 TNF 18518937 1971916 Although Cot/Tpl2 was phosphorylated in IRI and in the cultured tubular epithelial cells (TEC) after stimulation with LPS and hydrogen peroxide , there were no significant differences in terms of production , neutrophil infiltration or [MAPK] *activation* between Cot/Tpl2 ( +/+ ) and Cot/Tpl2 ( -/- ) mice . Positive_regulation MAPK1 TNF 18636175 1937266 Furthermore , glucosamine inhibited the *induced* phosphorylation of [p38MAPK] and NF-kappaB p65 , and the nuclear translocation of NF-kappaB in the cells . Positive_regulation MAPK1 TNF 18653803 1960513 PMA stimulated nSMase2 translocation was independent of p38 MAPK , and neither PKC inhibitors nor small interfering RNA had significant effects on *stimulated* p38 [MAPK] activation , indicating that PKC-delta does not act through p38 MAPK in regulating nSMase2 . Positive_regulation MAPK1 TNF 18710428 2028197 As for the signalling pathway , stimulation *led* to the phosphorylation of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and translocation of nuclear factor kappaB (NF-kappaB) ( p65 ) into the nuclei . Positive_regulation MAPK1 TNF 18710428 2028215 These data suggest that interaction *leads* to the phosphorylation of [Erk1/2] and p38MAPK and nuclear translocation of NF-kappaB , which is closely associated with the production and activation of MMP-9 in cultured CC cells of HuCTT-1 and CCKS-1 . Positive_regulation MAPK1 TNF 18768892 1957207 Consistently , Nod2-null macrophages tolerant to LPS and MDP showed enhanced production of and IL-6 as well as increased NF-kappaB and [MAPK] *activation* in response to the dipeptide KF1B , the Nod1 agonist . Positive_regulation MAPK1 TNF 18948845 2053236 Hypertonic saline did not alter *induced* p38 [mitogen activated protein kinase] phosphorylation or constitutive vascular endothelial growth factor expression , suggesting that the observed inhibition is not a generalized suppression of protein phosphorylation or cellular function . Positive_regulation MAPK1 TNF 19100731 2031217 at 30 ng/ml significantly *increased* phosphorylation of receptor tyrosine kinase ( 175 kDa ) and p42 [mitogen activated protein (MAP) kinase] . Positive_regulation MAPK1 TNF 19130554 2025296 Stimulation of HIMEC with *triggered* phosphorylation of the [MAPK] , and up-regulation of VCAM-1 , FKN and ICAM-1 . Positive_regulation MAPK1 TNF 19234337 2079506 Analysis of downstream signals showed that inhibition of NAD(P)H oxidase partially inhibited NF-kappaB activation but did not reduce CCL2 mRNA stability or prevent *induced* phosphorylation of [p38MAPK] . Positive_regulation MAPK1 TNF 19275968 2072840 *stimulated* the phosphorylation levels of p38 [MAPK] , JNK , ERK1/2 and Akt in vascular endothelial cells . Positive_regulation MAPK1 TNF 19289468 2073034 The requirement for MADD was highly specific for induced *activation* of [MAPK] but not the related JNK and p38 kinases . Positive_regulation MAPK1 TNF 19371952 2081758 Of note , the IFN-gamma plus *stimulated* activation of p38 [MAPK] was suppressed following incubation with forskolin or DBcAMP alone . Positive_regulation MAPK1 TNF 19410630 2089691 By transfection of TAK1 siRNA , *induced* phosphorylation of IkappaBalpha , JNK1/2 , and [p38MAPK] , as well as IL-6 or IL-8 expression , were repressed . Positive_regulation MAPK1 TNF 19427347 2106790 *induced* the phosphorylation of p38 [mitogen activated protein (MAP) kinase] , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation MAPK1 TNF 19429670 2106855 Ang II and clearly *enhanced* ERK and [p38MAPK] phosphorylation . Positive_regulation MAPK1 TNF 19563733 2122004 Finally , EZS inhibited *induced* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phosphorylation . Positive_regulation MAPK1 TNF 19631264 2143005 The treatment of cells with piceatannol inhibited cell proliferation by reducing extracellular signal regulated kinase ( [ERK) 1/2] and JNK activity in cultured VSMC in the *presence* of . Positive_regulation MAPK1 TNF 19648110 2138327 This correlates with reduced *stimulated* p38 [MAPK] phosphorylation . Positive_regulation MAPK1 TNF 19648110 2138342 Repression of *induced* p38 [MAPK] phosphorylation , NF-kappaB dependent transcription , and IL-8 expression by dexamethasone are sensitive to transcriptional or translational inhibitors . Positive_regulation MAPK1 TNF 19648110 2138413 Thus , MKP-1 attenuates *dependent* activation of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Positive_regulation MAPK1 TNF 19648110 2138440 Small interfering RNA knockdown of dexamethasone induced MKP-1 expression partially reverses the repression of *activated* p38 [MAPK] , demonstrating that MKP-1 participates in the dexamethasone dependent repression of this pathway . Positive_regulation MAPK1 TNF 19788916 2163918 ( TNF-alpha ) and H ( 2 ) O ( 2 ) *activate* [mitogen activated protein kinase (MAPK)] in SH-SY5Y cells within 5 min and this activation is completely blocked by DLPC ( 12 microM ) . Positive_regulation MAPK1 TNF 19877072 2160707 CpdA also displayed profound effects on induced [MAPK] *activation* . Positive_regulation MAPK1 TNF 19877072 2160724 In sharp contrast , DEX did not affect *induced* IKK phosphorylation , IkappaBalpha degradation , p65 nuclear translocation , or [MAPK] activation in RA FLS . Positive_regulation MAPK1 TNF 19889458 2197299 Calpain inhibition induces random migration in TNF-alpha stimulated cells and prevents the generation of reactive oxygen species , but does not alter *mediated* activation of p38 [MAPK] and ERK MAPK . Positive_regulation MAPK1 TNF 20131228 2219913 Furthermore , addition of exogenous IL-18BPa-Fc reduced the RA synovial fibroblast phosphorylation of [ERK-1/2] *induced* by . Positive_regulation MAPK1 TNF 20231691 2237854 TNF-alpha treatment resulted in the phosphorylation of p38 MAPK and its downstream target , MAPK activated protein kinase-2 , but IFN-gamma did not affect the levels of [MAPK] and MAPK activated protein kinase-2 phosphorylation *induced* by . Positive_regulation MAPK1 TNF 20463356 2301065 By Western blot analysis , we found that rapidly and significantly *increased* phosphorylation of IKBKB , [MAPK1/3] , and MAPK8/9/10 and that the phosphorylation of these kinases by TNF was reduced significantly by TNFRSF1A neutralizing antibody , but not by TNFRSF1B neutralizing antibody . Positive_regulation MAPK1 TNF 20489729 2327416 induced *activation* of p38 [MAPK] and the production of inducible nitric oxide synthase were suppressed in ASK1-deficient Müller glial cells . Positive_regulation MAPK1 TNF 20646342 2292545 Effects of budesonide on P38 [MAPK] activation , apoptosis and IL-8 secretion , *induced* by and Haemophilus influenzae in human bronchial epithelial cells . Positive_regulation MAPK1 TNF 20646342 2292573 *induced* a significant increase in p38 [MAPK] phosphorylation . Positive_regulation MAPK1 TNF 20693316 2351474 In four of the six donors , basal and *induced* ERK and p38 [MAPK] activation were higher in ASMA than ASMNA cells . Positive_regulation MAPK1 TNF 20696856 2351505 Surprisingly , replenishment with exogenous GSH normalizes both *dependent* NF-?B as well as [MAPK] signaling and rescues hepatocytes from FKB induced death . Positive_regulation MAPK1 TNF 20951126 2364944 Taken together , this study provided first evidence demonstrating that TRAIL- , , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK1 TNF 21123734 2377718 The ability of CO to inhibit *induced* ERK1/2 and p38 [MAPK] activities in an Akt dependent manner appears to be the key element in ROS dependent survival of endothelial cells during TNF-a mediated brain inflammatory disease . Positive_regulation MAPK1 TNF 21181166 2499601 IL-1ß and *activated* the intracellular mitogen activated protein kinases ( MAPKs ) : p44/42 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) as well as nuclear factor-?B ( NF-?B ) in osteoblasts . Positive_regulation MAPK1 TNF 21285293 2425716 Inhibitors of NADPH oxidase and/or p47phox siRNA diminished ROS production and COX-2 expression as well as phosphorylation of p38 [mitogen activated protein kinase] ( p38MAPK ) and Akt *mediated* either by AS serum or by . Positive_regulation MAPK1 TNF 21320357 2393857 The effects of IL-1ß and on EPCR shedding in DU-145 cells are *mediated* by [MEK/ERK 1/2] , JNK , and p38 MAPK signalling cascades . Positive_regulation MAPK1 TNF 21336587 2457985 Effects of preconditioning with sevoflurane on induced permeability and *activation* of p38 [MAPK] in rat pulmonary microvascular endothelial cells . Positive_regulation MAPK1 TNF 21422246 2416764 Interestingly , all PHA-L ( high ) DCs displayed a strongly reduced responsiveness to induced [p38-MAPK] *activation* compared with PHA-L ( low ) DCs , indicating differences in PHA-L binding capacities between DCs with different inflammatory properties . Positive_regulation MAPK1 TNF 21422246 2416778 Moreover , hybrid-type , but not complex-type , N-glycans are required for induced [p38-MAPK] *activation* and subsequent phenotypic maturation of BMDCs ( MHC-II , CD86 , CCR7 upregulation ) . Positive_regulation MAPK1 TNF 21493783 2499814 Moreover , *led* to up-regulation of the [ERK1/ERK2] and p38 MAPKs pathways , with only the latter being sensitive to pretreatment with the glucocorticoid dexamethasone . Positive_regulation MAPK1 TNF 21520062 2423117 Here , we report that *induced* cPLA(2) protein and mRNA expression , PGE ( 2 ) production , and phosphorylation of p42/p44 MAPK , p38 [MAPK] , and JNK1/2 , which were attenuated by pretreatment with a ROS scavenger [ N-acetyl-L-cysteine , ( NAC ) ] and the inhibitors of NADPH oxidase [ apocynin (APO) and diphenyleneiodonium chloride ( DPI ) ] , MEK1/2 ( U0126 ) , p38 MAPK ( SB202190 ) , and JNK1/2 ( SP600125 ) or transfection with siRNA of Nox2 , p47(phox) , MEK1 , p42 , p38 , or JNK2 . Positive_regulation MAPK1 TNF 21545687 2554376 significantly *induced* phosphorylation of p38 [MAPK] , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation MAPK1 TNF 21894146 2510858 Vehicle and untreated NTN exhibited heavy proteinuria and glomerular thrombosis at 24 h with P-selectin and fibrin immunostaining within capillaries , glomerular macrophage and T cell infiltration , *activation* of JNK and p38 [MAPK] signalling , and upregulation of glomerular mRNA levels of pro-inflammatory molecules ( , NOS2 , MMP-12 and CCL2 ) . Positive_regulation MAPK1 TNF 22002864 2526323 These results suggest that H ( 2 ) O ( 2 ) -induced secretion of *increases* apoptosis of cardiac myocytes through ROS dependent activation of p38 [MAPK] . Positive_regulation MAPK1 TNF 22227193 2544572 Casuarinin significantly inhibited induced *activation* of NF-?B , STAT1 , and p38 [MAPK] . Positive_regulation MAPK1 TNF 22230399 2519472 KMUP-1 inhibited *induced* iNOS and U46619 induced PDE-5A and phospho-p38 [MAPK] in normoxia , confirming its anti-proinflammatory action . Positive_regulation MAPK1 TNF 22250084 2551207 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Positive_regulation MAPK1 TNF 22343222 2617802 Using immunohistological techniques , we showed a higher epithelial expression of , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator [protein-1/mitogen activated protein kinase] signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation MAPK1 TNF 22525504 2522568 *up-regulated* the phosphorylation levels of p38 [MAPK] and increased the translocation of NF-kB p65 protein into the nucleus , also proved by immunofluorescence staining . Positive_regulation MAPK1 TNF 22526394 2595909 also *increased* the production of inducible nitric oxide synthase (iNOS) , nitric oxide ( NO ) , and intercellular adhesion molecule 1 ( ICAM-1 ) through activation of p38 [mitogen activated protein kinase (MAPK)] from HT-29 cells . Positive_regulation MAPK1 TNF 22773691 2659898 induced *activation* of p38 [MAPK] and NF-?B was attenuated by miR-140-3p mimic . Positive_regulation MAPK1 TNF 22819264 2646091 CORM-2 inhibited induced *activation* of p38 [MAPK] , ERK1/2 , JNK , and NF-?B signaling pathways in HUVECs . Positive_regulation MAPK1 TNF 22947346 2678657 *induced* phosphorylated p38 [mitogen activated protein kinase] levels were increased in ASMCs from patients with severe asthma compared with those from patients with nonsevere asthma and nonasthmatic subjects , whereas TNF-a induced phosphorylated c-Jun N-terminal kinase and phosphorylated extracellular signal related kinase levels were increased in all asthmatic groups . Positive_regulation MAPK1 TNF 22988345 2674351 The EGF receptor and HER2 participate in dependent [MAPK] *activation* and IL-8 secretion in intestinal epithelial cells . Positive_regulation MAPK1 TNF 22988345 2674379 As the epidermal growth factor receptor (EGFR) is a known transducer of proliferative signals and a potent activator of MAPKs , we hypothesized that the EGFR participates in dependent [MAPK] *activation* and IL-8 secretion by intestinal epithelial cells ( IECs ) . Positive_regulation MAPK1 TNF 23071098 2720897 Mixed-effects modeling analysis of our data was vital for ascertaining that IL-1a and TGF-a treatment increased the activities of more pathways than IL-6 and TNF-a and that TGF-a and *increased* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phospho-protein levels in a synergistic manner . Positive_regulation MAPK1 TNF 23142559 2722782 Western blot analysis revealed that pilocarpine and physostigmine enhanced the *induced* phosphorylation of ERK1/2 and p38 [MAPK] and the degradation of I?Ba . Positive_regulation MAPK1 TNF 23159491 2729678 Finally , we demonstrate that the transmembrane forms of wild-type and palmitoylation-defective interact differently with TNFR1 and *regulate* NF?B activity , [Erk1/2] phosphorylation and interleukin-6 synthesis differently , strongly suggesting that palmitoylation of TNF is involved in the regulation of TNFR1 signalling . Positive_regulation MAPK1 TNF 23333920 2758380 Interestingly , IL-27 promoted the basal and enhanced *induced* phosphorylation of p38 [MAPK] and Akt , but not I?Ba . Positive_regulation MAPK1 TNF 23353699 2754236 We further demonstrated that markedly *stimulated* p38 [MAPK] , p42/p44 MAPK , and JNK1/2 phosphorylation via a c-Src/EGFR , PDGFR/PI3K/Akt pathway . Positive_regulation MAPK1 TNF 23354775 2770331 p38a [mitogen activated protein kinases (MAPK)] may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , , interleukin-1ß , and oxidative stress . Positive_regulation MAPK1 TNF 23664593 2838379 sFGL2 secretion by CD4 ( + ) T cells can be *induced* with and IFN-? stimulation through [MAPK] signaling in renal allograft AR . Positive_regulation MAPK1 TNF 23699531 2792339 Recombinant PGRN or transfection of a cDNA encoding PGRN did not antagonize *dependent* NF?B , Akt , and [Erk1/2] pathway activation ; Positive_regulation MAPK1 TNF 23861542 2817203 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Positive_regulation MAPK1 TNF 23884101 2821464 Furthermore , P. vulgaris extract suppressed *induced* phosphorylation of p38 [mitogen activated protein kinase (MAPK)] and extracellular signal regulated kinase ( ERK ) . Positive_regulation MAPK1 TNF 23935096 2840757 In contrast , loss of SK1 prevented *induced* phosphorylation of p38 [MAPK] , and inhibition of p38 MAPK , like SK1 knockdown , also potentiates RANTES induction . Positive_regulation MAPK1 TNF 24039713 2842343 *induced* nuclear localization of phosphorylated [ERK 1/2] ( p-ERK 1/2 ) correlated with increased apoptosis in TR1- and Trx1-deficient cells , suggesting a pro-apoptotic role for nuclear p-ERK 1/2 in TNF-a induced apoptosis . Positive_regulation MAPK1 TNF 24039713 2842345 In addition , phosphoinositide 3-kinase (PI3K) inhibition dramatically reduced *stimulated* apoptosis and nuclear localization of [p-ERK 1/2] . Positive_regulation MAPK1 TNF 24069158 2846989 We showed that markedly *stimulated* p42/p44 MAPK , p38 [MAPK] , and JNK1/2 phosphorylation which were attenuated by their respective inhibitors . Positive_regulation MAPK1 TNF 24080497 2902535 Consistently , DUSP1 promotes apoptosis and decreases NF-?B activity in cells in which p38 [MAPK] is *induced* by treatment . Positive_regulation MAPK1 TNF 24089494 2848146 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed receptor 1 and *requires* activation of p38 [MAPK] , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation MAPK1 TNF 24361597 2911241 We further demonstrated that *stimulated* ERK1/2 , p38 [MAPK] , and JNK1/2 phosphorylation via a c-Src dependent PDGFR/PI3K/Akt pathway . Positive_regulation MAPK1 TNF 24378531 2911769 TRAF2 has been previously reported to be required for induced *activation* of p38 [MAPK] . Positive_regulation MAPK1 TNF 24441870 2922929 We showed that markedly *stimulated* Jak2 , PDGFR , Akt , and p42/p44 [MAPK] phosphorylation , which were attenuated by their respective inhibitors . Positive_regulation MAPK1 TNF 24441870 2922947 In addition , *induced* p42/p44 [MAPK] phosphorylation was reduced by AG1296 or LY294002 . Positive_regulation MAPK1 TNF 24441870 2922983 On the other hand , could *induce* Akt and p42/p44 [MAPK] translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation MAPK1 TNF 24446489 2912934 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Positive_regulation MAPK1 TNF 24489443 2884788 Finally , by investigating the intracellular pathways involved in promoting the VEC release of cytokines/chemokines , which are targeted by natural anti-inflammatory compounds , we documented that aLipoic acid significantly counteracted *induced* NF-?B and [p38/MAPK] activation while the effects of Ginkgo biloba appeared to be predominantly mediated by Akt . Positive_regulation MAPK1 TNF 24507356 2914241 The results showed that the treatment of macrophages with CS3 could not only increase the nitric oxide ( NO ) release and the cytokines , IL-6 and IL-1ß production significantly , but also *enhance* the inducible NOS (iNOS) expression , NF-?Bp65 nuclear translocation , [Erk1/2] and SAPK/JNK phosphorylation . Positive_regulation MAPK1 TNF 24750790 2936557 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas and NO production *required* all three [MAPK] . Positive_regulation MAPK1 TNF 7499190 332611 Preferential involvement of MEK1 in the *induced* activation of [p42mapk/erk2] in mouse macrophages . Positive_regulation MAPK1 TNF 7636214 317424 To investigate the use of CD120a ( p55 ) and CD120b ( p75 ) in the activation of p42mapk/erk2 in mouse macrophages , we determined the effects of blocking Ab on the activation of [p42mapk/erk2] in *response* to . Positive_regulation MAPK1 TNF 7689564 225760 *induced* activation and increased tyrosine phosphorylation of [mitogen activated protein (MAP) kinase] in human fibroblasts . Positive_regulation MAPK1 TNF 7689564 225773 induced *activation* of [MAPK] was demonstrated by its enhanced ability to phosphorylate myelin basic protein in vitro and by a characteristic shift in the electrophoretic mobility of MAPK proteins . Positive_regulation MAPK1 TNF 7722327 301753 *induces* tyrosine phosphorylation of [mitogen activated protein kinase] in adherent human neutrophils . Positive_regulation MAPK1 TNF 7722327 301779 PMN pretreatment with genistein , a tyrosine kinase inhibitor , inhibited the *induced* increase in tyrosine phosphorylation and [MAPK] activity . Positive_regulation MAPK1 TNF 7726846 302075 Since we recently found that stimulation of neutrophils does not *increase* the tyrosine phosphorylation or activation of the [p42erk2] and p44erk1 mitogen activated protein kinases ( MAPKs ) , the present studies demonstrate the involvement of a MAPK independent pathway in the phosphorylation and activation of cPLA2 . Positive_regulation MAPK1 TNF 8626494 360272 Inhibition of *induced* p42/p44 [mitogen activated protein kinase] activation by sodium salicylate . Positive_regulation MAPK1 TNF 8626494 360286 *activates* both p42 and p44 [mitogen activated protein kinases (MAPK)] in human FS-4 fibroblasts , cells for which TNF is mitogenic . Positive_regulation MAPK1 TNF 8626494 360299 We now show that *activates* p42 [MAPK] in two cell lines whose growth is inhibited by TNF . Positive_regulation MAPK1 TNF 8626494 360314 We now show that neither phorbol ester-sensitive protein kinase C nor Gialpha link TNF to p42/p44 MAPK activation , because pretreatment of FS-4 cells with phorbol ester to down-regulate protein kinase C or pretreatment with pertussis toxin to block Gialpha does not inhibit p42/p44 [MAPK] *activation* by . Positive_regulation MAPK1 TNF 8626494 360332 To further analyze MAPK activation in FS-4 cells , we compared p42/p44 [MAPK] *activation* by and epidermal growth factor (EGF) . Positive_regulation MAPK1 TNF 8626494 360359 Elucidation of the mechanism whereby sodium salicylate blocks induced p42/p44 [MAPK] *activation* may help to clarify TNF activated signaling pathways . Positive_regulation MAPK1 TNF 8662702 367178 additionally *caused* rapid p38 and JNK-1 [mitogen activated protein kinase] activation and efficient NF-kappaB translocation , which could not be achieved even by high levels of ceramide . Positive_regulation MAPK1 TNF 9106254 424405 The increases in [MAPK] *induced* by and IL-1 were similar to the increases induced by PMA and PDGF-AB . Positive_regulation MAPK1 TNF 9106254 424431 Our findings indicate that and IL-1 activate parallel signal transduction pathways in human neuroma fibroblasts , and that they are relatively stronger *activators* of [MAPK] than of SAPK . Positive_regulation MAPK1 TNF 9315666 456096 , an inhibitor of insulin stimulated adipogenesis , *activated* [MAPK] in 3T3-L1 cells . Positive_regulation MAPK1 TNF 9439626 482865 *increased* ERK1 and ERK2 [MAPK] phosphorylation . Positive_regulation MAPK1 TNF 9439626 482891 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic effect of *requires* protein tyrosine phosphorylation and [MAPK] activation . Positive_regulation MAPK1 TNF 9530111 496720 *Activation* of [p42mapk] in human umbilical vein endothelial cells by interleukin-1 alpha and . Positive_regulation MAPK1 TNF 9530111 496724 Genistein , but not Ro-31-8220 , attenuated IL-1 alpha- and *induced* [p42mapk] activation . Positive_regulation MAPK1 TNF 9593119 505481 The CAZ released endotoxin was similar to purified LPS with respect to the following biological activities in LPS-responsive C3H/HeN mice and LPS-hyporesponsive C3H/HeJ mice : lethal toxicity in GalN sensitized mice , in vitro induction of and NO production by macrophages , and [mitogen activated protein kinase] *activation* in macrophages . Positive_regulation MAPK1 TNF 9624172 511399 These results show that IL-1beta- or induced LDL receptor expression *requires* [ERK-1/2] activation , that the p38 ( MAPK ) pathway negatively regulates LDL receptor expression , and that sterols inhibit induction at a point downstream of ERK-1/2 in HepG2 cells . Positive_regulation MAPK1 TNF 9766635 538500 Our data suggest that and GM-CSF *activate* ERKs and p38 [MAPK] by different signal transduction pathways . Positive_regulation MAPK1 TNF 9770326 538798 Furthermore , *induction* of p42/p44 ERK and [p38-MAPK] phosphorylation , c-jun kinase activation , and IkappaBalpha degradation were normal . Positive_regulation MAPK1 TNF 9883899 558204 *Activation* of p42/p44 [mitogen activated protein kinases (MAPK)] and p38 MAPK by is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation MAPK1 TNF 9883899 558219 Here , we demonstrate that is *sufficient* to activate p42/p44 MAPK and p38 [MAPK] . Positive_regulation MAPK1 TNF 9930718 588833 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Positive_regulation MAPK1 TNF 9931102 588900 ( 100 U/mL ) transiently *activated* [MAPK] with a maximal induction 10 minutes after stimulation that returned to baseline levels by 2 hours after treatment . Positive_regulation MAPK1 TNF 9931102 588913 PD98059 also blocked *stimulated* [MAPK] activation in a concentration dependent manner , which is consistent with its inhibition of TNF-alpha directed migration . Positive_regulation MAPK1 TNF 9931102 588926 To identify which TNF-alpha receptor is involved in induced [MAPK] *activation* , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Positive_regulation MAPK1 TNF 9931102 588952 VSMC express both receptors , but *induced* [MAPK] activation was inhibited only by the TNF-R1 antibody . Positive_regulation MAPK1 TNF 9931102 588978 Both TRO and RSG inhibited migration , but neither attenuated induced [MAPK] *activation* , indicating that their antimigration activity was exerted downstream of MAPK . Positive_regulation MAPK1 TNFSF10 12969966 1185567 Among the intracellular pathways investigated , significantly *stimulated* the extracellular signal regulated kinase 1/2 ( ERK1/2 ) but not the [p38/mitogen activated protein kinase (MAPK)] or the c-Jun NH2-terminal kinase (JNK) pathway . Positive_regulation MAPK1 TNFSF10 20951126 2364945 Taken together , this study provided first evidence demonstrating that , TNF-a- , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK1 TNFSF10 21152872 2373389 Taken together , we show herein that the upstream molecule of the induced [MAPK] *activation* is MEKK , as opposed to ASK1 , via the mediation of its signal through JNK/p38 in a caspase-8 dependent manner . Positive_regulation MAPK10 ADRB2 11018034 752786 induced p38 [MAPK] *activation* is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes . Positive_regulation MAPK10 ADRB2 12509508 1038734 beta-Arrestin 1 is required for internalization and [mitogen activated protein (MAP) kinase] *activation* by the . Positive_regulation MAPK10 ADRB2 19047375 2023480 Hematopoietic protein tyrosine phosphatase mediates *induced* regulation of p38 [mitogen activated protein kinase] in B lymphocytes . Positive_regulation MAPK10 ADRB2 9038193 415361 In the present work , we report that stimulation of the A2A-adenosine receptor and of the *activates* [mitogen activated protein kinase] ( MAP kinase ) in human endothelial cells based on the following criteria : adenosine analogues and beta-adrenergic agonists cause an ( i ) increase in tyrosine phosphorylation of the p42 isoform and to a lesser extent of the p44 isoform of MAP kinase and ( ii ) stimulate the phosphorylation of myelin basic protein by MAP kinase; (iii) this is accompanied by a redistribution of the enzyme to the perinuclear region . Positive_regulation MAPK10 ADRB2 9363896 462904 We show that in HEK293 cells , *stimulation* of [mitogen activated protein (MAP) kinase] by the is mediated by the betagamma subunits of pertussis-toxin-sensitive G proteins through a pathway involving the non-receptor tyrosine kinase c-Src and the G protein Ras . Positive_regulation MAPK10 ALOX5 11807011 903504 In contrast , stress induced product formation and translocation of <5-LO> , as well as *activation* of p38 [MAPK] , occurred also after Ca ( ++ ) depletion . Positive_regulation MAPK10 ALOX5 21200133 2391680 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Positive_regulation MAPK10 ANGPT1 12039842 954277 Accordingly , ephrinB2 inhibited VEGF- and *induced* [Ras-MAPK] activities , whereas ephrinB2 did not alter VEGF induced Flk phosphorylation or Ang1 induced Tie2 phosphorylation . Positive_regulation MAPK10 ANGPT1 12213710 985635 Both VEGF and *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 [MAPK] . Positive_regulation MAPK10 ANGPT1 12213726 985705 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of and Ang-2 as well as the *activation* of [MAPK] , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation MAPK10 ANGPT1 16061664 1439065 *activated* [mitogen activated protein kinase (MAPK)] and phosphoinositide 3-kinase (PI3K) in IBE cells and HUVECs . Positive_regulation MAPK10 ANGPT1 16679392 1612149 Pretreatment with either DPI or apocynin also significantly attenuated *induced* Akt and p44/42 [MAPK] phosphorylation . Positive_regulation MAPK10 ANGPT1 16679392 1612165 Using mouse heart microvascular endothelial cells from wild-type ( WT ) mice and mice deficient in the p47(phox) component of NADPH oxidase ( p47 ( phox-/- ) ) , we found that although *stimulated* intracellular ROS , Akt and p42/44 [MAPK] phosphorylation , and cell migration in WT cells , the responses were strikingly suppressed in cells from the p47 ( phox-/- ) mice . Positive_regulation MAPK10 ANGPT1 20072135 2235283 *promoted* skin cell metabolism/viability , adhesion , and akt and [MAPK] ( p42/44 ) activations . Positive_regulation MAPK10 ANO1 22564524 2619158 *induces* [MAPK] and contributes directly to tumorigenesis and cancer progression . Positive_regulation MAPK10 CAPN8 21543591 2424061 Downstream , an Aß-mediated rise in p38 [mitogen activated protein kinase (MAPK)] activation was followed by downregulation of cAMP response element binding protein , and LTP impairment was *prevented* by inhibitors of p38 MAPK or . Positive_regulation MAPK10 CAPN8 24416390 2900929 Treatment with glutamate leads to early activation of NMDAR , which in turn leads to *mediated* cleavage of striatal enriched protein tyrosine phosphatase ( STEP ) and subsequent activation of p38 [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK10 CCL17 23711854 2792885 IL-33 induced the production of thymus and activation regulated and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 [MAPK] . Positive_regulation MAPK10 CCND1 11004713 735008 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping [ERK-MAPK] activation and c-Fos and *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation MAPK10 CCND1 12654183 1072980 [MAPK] may *induce* overexpression of protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation MAPK10 CCND1 15634644 1349550 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 [mitogen activated protein kinase] , and down-regulation of . Positive_regulation MAPK10 CCND1 16522728 1531454 We conclude that incretin induced beta-cell replication is dependent on cAMP/PKA , p42 [MAPK] and PI3K activities , which may *involve* transcriptional induction of . Positive_regulation MAPK10 CCND1 9537433 497552 Furthermore , in 25 of 26 cases of HCC which genomic DNA was available , 22 cases without genomic DNA amplification exhibited positive correlation , not only between protein expression of c-Fos and , but also between [MAPK/ERK] *activation* and cyclin D1 expression . Positive_regulation MAPK10 CD14 15625444 1349233 LPS interacts with the cell surface receptor , which generates transmembrane signals through Toll-like protein 4 *leading* to [mitogen activated protein kinase (MAPK)] p38 activation , cytokine synthesis , PMN beta2-integrin expression and oxidative burst . Positive_regulation MAPK10 CHI3L1 23755018 2797724 In addition , *induces* [FAK-MAPK] signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation MAPK10 CHI3L1 23972995 2836236 We also demonstrate that *activates* macrophage [mitogen activated protein kinase] , protein kinase B/AKT , and Wnt/ß-catenin signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation MAPK10 CLU 23051594 2702803 FOXL2 directly stimulates the Clu gene promoter , and we show that PTTG triggers ataxia telangiectasia mutated [kinase/IGF-I/p38MAPK] DNA damage/chromosomal instability signaling , which in turn also *induces* expression . Positive_regulation MAPK10 CTGF 11732999 885259 *induces* chondrocyte differentiation through a p38 [mitogen activated protein kinase] ( p38MAPK ) , and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase ( ERK ) . Positive_regulation MAPK10 CTGF 11732999 885273 In the proliferation phase , *induced* a approximately fivefold increase in the phosphorylation of p44/42 [MAPK/ERK] and a approximately twofold increase in that of p38 MAPK in an in vivo kinase assay . Positive_regulation MAPK10 CTGF 12218048 1012159 The inhibition of *induced* p42/44 [MAPK] or phosphatidylinositol 3-kinase (PI3K)/protein kinase B pathway activities abrogated the induction of fibronectin expression . Positive_regulation MAPK10 CTGF 16408113 1513474 *enhanced* the mRNA expression and protein release of fractalkine , MCP-1 , and RANTES , the expression of phospho ( P ) -p42/44 [mitogen activated protein kinase (MAPK)] , P-phosphoinositide 3-kinase (PI3-K) , P-Akt , and activity of nuclear factor-kappaB (NF-kappaB) in mesangial cells . Positive_regulation MAPK10 CTGF 16408113 1513496 P-p42/44 MAPK blockade inhibited the *induced* expression of P-p42/44 [MAPK] but not NF-kappaB , and partially decreased the levels of the above chemokines in supernatants . Positive_regulation MAPK10 CTGF 16522717 1531322 ( 3 ) *stimulated* dose dependent HSC adhesion and activity of p42/p44 [mitogen activated protein kinase] , the latter of which was antagonized by blocking the activity of focal adhesion kinase . Positive_regulation MAPK10 CTGF 16938382 1654121 No single module , but a mixture of the 4 modules provoked a significant activation of p38 [MAPK] in HCS-2/8 cells , which was *activated* by the full-length . Positive_regulation MAPK10 CTGF 19038999 2023077 Interestingly , CCN2-BMP-2 did not affect the *induced* phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Positive_regulation MAPK10 EDN2 12193071 980922 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Positive_regulation MAPK10 EDN2 12475899 1037760 *induced* a rapid phosphorylation of the [mitogen activated protein kinase (MAPK)/ERK] and increased collagen I gene activity in freshly isolated aortas . Positive_regulation MAPK10 EDN2 1280103 203027 rapidly *stimulates* [mitogen activated protein kinase] activity in rat mesangial cells . Positive_regulation MAPK10 EDN2 12855582 1149878 also *induced* the activation of p42/44 [mitogen activated protein kinase (MAPK)] in DCs . Positive_regulation MAPK10 EDN2 7509933 241594 *stimulates* [mitogen activated protein kinase] p42 activity through the phosphorylation of the kinase in rat mesangial cells . Positive_regulation MAPK10 EDN2 7849246 286718 *stimulates* [mitogen activated protein kinase] activity in mesangial cells through ETA . Positive_regulation MAPK10 EDN2 7943276 276385 has been shown to *activate* [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK10 EDN2 8836145 386159 In bovine airway smooth-muscle cells platelet derived growth factor ( PDGF ) and ( Et-1 ) *stimulate* sustained and comparable activation of [mitogen activated protein kinase] ( MAP kinase ) but display very different mitogenic efficacies , with PDGF inducing 50 times more DNA synthesis than Et-1 . Positive_regulation MAPK10 EFNB1 15502157 1347557 Further downstream of the signaling pathway , stimulation *led* to increased LAT ( linker for activation of T-cells ) phosphorylation and p44/42 and p38 [MAPK] activation . Positive_regulation MAPK10 EPHB2 10601128 574195 Tumor necrosis factor-alpha (TNF-alpha) alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only . Positive_regulation MAPK10 EPHB2 10872747 707022 Pre-treatment of the cells with PD98059 , a selective pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation MAPK10 EPHB2 11083274 750488 Tumor necrosis factor alpha , interleukin-1 (IL-1) , and IL-6 were the major inducers of , JNK , and p38 [MAPK] *activation* in cultured human synovial cells . Positive_regulation MAPK10 EPHB2 12386816 999760 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 [MAPK] and a biphasic *activation* of . Positive_regulation MAPK10 EPHB2 12403788 1036173 SB203580 , a p38 [MAPK] *inhibitor* , and PD98059 , an inhibitor , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation MAPK10 EPHB2 12486127 1056305 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain *had* little effect on basal Erk [MAPK] activation . Positive_regulation MAPK10 EPHB2 12511425 1070734 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation MAPK10 EPHB2 12801927 1120229 GE2 stimulation *induced* phosphorylation , whereas it did not alter the phosphorylation of c-Jun N-terminal kinase or p38 [MAPK] . Positive_regulation MAPK10 EPHB2 12832293 1105574 Exposure to E. coli DNA resulted in phosphorylation of ERK 1/2 [MAPK] and inhibitors of activity ( PD98059 , UO126 ) significantly *reduced* the evoked IL-8 production . Positive_regulation MAPK10 EPHB2 12878192 1115516 ( 2 ) the *activation* of JNK and p38 [MAPK] but not in embryonic fibroblasts ( MEFs ) derived from ASK1 knockout mice ( ASK1 ( -/- ) MEFs ) was depressed compared to MEFs derived from wild type mice ( ASK1 ( +/+ ) MEFs ) ; Positive_regulation MAPK10 EPHB2 14973553 1212531 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen activated protein kinase (MAPK)] signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation MAPK10 EPHB2 14998726 1216727 Furthermore , we found that PD98059 , an pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation MAPK10 EPHB2 15659876 1350301 The anabolic effect of TNF-alpha was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an . Positive_regulation MAPK10 EPHB2 16038626 1437403 SF significantly prevented Abeta induced increases in IL-1beta and p38 [MAPK] *activation* and also Abeta induced changes in and phospho-Akt/PKB expression levels . Positive_regulation MAPK10 EPHB2 17056059 1649524 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Positive_regulation MAPK10 EPHB2 17403539 1735931 Trauma-hemorrhage increased the production of IL-6 , IL-10 , IL-12 and TNF-alpha enhanced the expression of TLR4 , MyD88 as well as the *activation* of [MAPK] proteins ( p38 , and JNK ) in epidermal keratinocytes . Positive_regulation MAPK10 EPHB2 17416211 1777855 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK10 EPHB2 17464174 1731742 The mRNA and surface protein up-regulation of CCR1 and CCR2 in 9CRA stimulated cells were weakly blocked by the pretreatment of SB202190 , a p38 [MAPK] *inhibitor* , and PD98059 , an upstream inhibitor . Positive_regulation MAPK10 EPHB2 18164124 1869607 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 [MAPK] , but not by the *activation* of JNK , , and NF-kappaB pathway . Positive_regulation MAPK10 EPHB2 18266967 2000293 VEGF induced activation of p42 also *led* to the nuclear translocation of [MAPK/ERK1/2] . Positive_regulation MAPK10 EPHB2 18285354 1885403 Pre-treatment with the [MAPK] *inhibitors* SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( inhibitor ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation MAPK10 EPHB2 18338254 1938055 Interestingly , inhibition of by U0126 completely *prevented* artepillin C-induced p38 [MAPK] phosphorylation of PC12m3 cells . Positive_regulation MAPK10 EPHB2 18520049 1918670 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of , rather than by the *activation* of p38 [MAPK] , in the spinal cord . Positive_regulation MAPK10 EPHB2 18982426 2105744 These inhibitory effects were partially inhibited by SB203580 , a specific *inhibitor* of p38 [MAPK] , but not by PD98059 , a specific inhibitors of extracellular signal regulated kinase ( ) , and SP600125 , a specific inhibitor of c-Jun-N-terminal kinase (JNK) . Positive_regulation MAPK10 EPHB2 19189219 2113959 Moreover , EM1 treatment resulted in less activation of p38 [MAPK] and more *activation* of signaling in lipopolysaccharide stimulated DCs . Positive_regulation MAPK10 EPHB2 19276187 2051415 Treatment of cells with sphingosine induced suppression of and *activation* of p38 [MAPK] . Positive_regulation MAPK10 EPHB2 19429670 2106918 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either inhibitor , [p38MAPK] *inhibitor* or NF-kappaB inhibitor . Positive_regulation MAPK10 EPHB2 19522739 2103138 Treatment with [MAPK] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation MAPK10 EPHB2 19672126 2168061 A scratch wound assay of healing rates in SV40 immortalized human corneal epithelial cell line ( HCEC ) evaluated the relative contributions by p38 and and JNK [MAPK] signaling *activation* to wound healing . Positive_regulation MAPK10 EPHB2 20025124 2175510 Prior treatment of the cells with PD98059 , an kinase inhibitor or SB203580 , a [p38MAPK] *inhibitor* , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation MAPK10 EPHB2 20554538 2327619 The HNE enhanced Sp1 and NF-?B activities were attenuated by SB203580 , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , and PD98059 , an extracellular signal regulated kinase ( ) inhibitor , respectively . Positive_regulation MAPK10 EPHB2 21126656 2355796 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 [mitogen activated protein kinase] , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by . Positive_regulation MAPK10 EPHB2 21311676 2360031 Treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation MAPK10 EPHB2 21488184 2417970 Dexmedetomidine induced phosphorylation of JNK and p38 [MAPK] in rat aortic SMCs , but did not *induce* phosphorylation of . Positive_regulation MAPK10 EPHB2 21586573 2449663 Incubation of T cells with ESAT-6 induced phosphorylation and increased functional p38 [MAPK] activity , but not *activation* of or JNK . Positive_regulation MAPK10 EPHB2 21599960 2445720 In the present studies , induction of central sensitization as indicated by spinal dorsal horn [MAPK] *activation* , specifically and p38 phosphorylation , was assessed in the MIA-OA model . Positive_regulation MAPK10 EPHB2 23394443 2713230 When compared to hamsters bearing tumors that remained on the control diet , the buccal pouches of hamsters bearing tumors receiving turmeric showed the following results : ( 1 ) decreased cell proliferation ( diminished PCNA , cyclin D1 , and Bcl-2 ) and PCNA labelling index , ( 2 ) enhanced apoptosis ( increased Bax , caspase-3 , caspase-9 , and cytochrome c , and decreased survivin ) and apoptotic index , ( 3 ) decreased inflammation ( decreased Cox-2 ) , and ( 4 ) decreased [MAPK] *activation* ( and p-p38 ) . Positive_regulation MAPK10 EPHB2 23892041 2830332 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three [MAPK] *inhibitors* ( inhibitor PD98059 , JNK inhibitor SP600125 and p38 inhibitor SB203580 ) . Positive_regulation MAPK10 EPHB2 23914844 2840568 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 [MAPK] and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of , JNK , NF-?B . Positive_regulation MAPK10 EPHB2 23917355 2826015 Inhibition of Akt or activity *reduced* phosphorylation of STAT1 in Colon26L5-CUG2 cells whereas inhibition of p38 [MAPK] did not significantly decrease levels of STAT1 phosphorylation , indicating that cell proliferation signals may be involved in CUG2 mediated activation of STAT1 . Positive_regulation MAPK10 EPHB2 24225419 2897492 Therefore , by using the [MAPK] *inhibitors* SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific inhibitor ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation MAPK10 EPHB2 24297112 2894213 Following treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation MAPK10 F2R 16052512 1460022 The p38 and ERK1/2 [MAPK] signaling cascades were also *activated* by stimulation , whereas the SAPK/JNK pathway was unaffected . Positive_regulation MAPK10 F2R 16467309 1548147 and PAR-2 stimulation rapidly *activated* both ERK1/2 and [p38MAPK] , and pharmacological blockade of MEK with either PD98059 or U0126 or of p38MAPK by SB203580 or SB202190 strongly inhibited thrombin- and SLIGKV induced COX-2 expression and 6-keto-PGF1alpha formation . Positive_regulation MAPK10 F2R 21252088 2402882 In the present study , we show that FVIIa , upon binding to EPCR on endothelial cells , activates endogenous protease activated receptor-1 (PAR1) and induces mediated p44/42 [mitogen activated protein kinase (MAPK)] *activation* . Positive_regulation MAPK10 F2R 24052258 2867013 However , the distinct non-canonical tethered ligands unmasked by neutrophil elastase and proteinase-3 , as well as synthetic peptides with sequences derived from these novel exposed tethered ligands , selectively stimulated mediated [mitogen activated protein kinase] *activation* . Positive_regulation MAPK10 F2R 8635212 357854 These results support the notion that the *activates* [MAPK] through PKC dependent pathways and that the incremental activation of MAPK by TRAP over that induced by thrombin is the consequence of enhanced activation through the PKC limb of the phosphoinositide lipid pathway . Positive_regulation MAPK10 FAS 14576831 1156602 A more physiological inhibitor , the intracellular PP2A inhibitor protein I2 ( PP2A ) , protected transfected HeLa cells in a similar way from *mediated* apoptosis and induced activation of [MAPK] in I2 ( PP2A ) transfected cells . Positive_regulation MAPK10 FAS 15280387 1302529 We further demonstrate that this pro-apoptotic effect of CO was independent of reactive oxygen species production and involved inhibition in *induced* activation of the pro-survival ERK [MAPK] . Positive_regulation MAPK10 FAS 16507991 1529629 Here we show that binding of Fas ligand to *activates* p38 [MAPK] in CD8+ T cells and that activation of this pathway is required for Fas mediated CD8+ T-cell death . Positive_regulation MAPK10 FAS 19417161 2179807 GST-MDA-7 killing was , in parallel , dependent on inactivation of extracellular signal regulated kinase 1/2 and on *induced* p38 [mitogen activated protein kinase] and c-jun NH ( 2 ) -terminal kinase-1/2 signaling . Positive_regulation MAPK10 FAS 21613257 2454273 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Positive_regulation MAPK10 FAS 21975294 2492840 Caspase-8 activity has an essential role in mediated [MAPK] *activation* . Positive_regulation MAPK10 FAS 8977313 403343 IFN-alpha2 did not alter the *induced* activity of [Mitogen activated protein kinase (MAPK)] 1 and did not inhibit the Apo-1/Fas mediated proteolytic cleavage of ADP-ribosyltransferase , a substrate of Interleukin-beta1 converting enzyme ( ICE ) and homologues . Positive_regulation MAPK10 FHL1 23456229 2781814 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Positive_regulation MAPK10 FOXA1 22879989 2641679 An increase in IGFBP-3 , mediated by depletion of , *inhibited* phosphorylation of [MAPK] and Akt , and increased expression of the cell cycle regulators p21 and p27 . Positive_regulation MAPK10 FUT4 20506505 2307952 These data suggested that not only *activates* [MAPK] and PI3K/Akt signals , but also promotes the crosstalk among these signaling pathways . Positive_regulation MAPK10 GLP1R 21356521 2394812 activation by Exendin-4 ( Ex-4 ) *increased* PKA and [MAPK] activity and decreased phosphorylation of AMPK in NTS . Positive_regulation MAPK10 GPR115 10958680 725144 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK10 GPR115 11916960 944896 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK10 GPR115 9182581 435090 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK10 GPR115 9826186 549487 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK10 GPR132 10958680 725133 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK10 GPR132 11474113 841735 Activation of by LPC *increased* intracellular calcium concentration , induced receptor internalization , activated ERK [mitogen activated protein kinase] , and modified migratory responses of Jurkat T lymphocytes . Positive_regulation MAPK10 GPR132 11916960 944885 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK10 GPR132 9182581 435079 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK10 GPR132 9826186 549476 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK10 GPR87 10958680 725213 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK10 GPR87 11916960 944965 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK10 GPR87 9182581 435159 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK10 GPR87 9826186 549556 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK10 GRIK2 15308300 1284886 These results indicate that PSD-95 plays an important role in the formation of the . PSD-95 . MLK3 signaling module and MLK3 and [JNK3] *activation* in postischemic rat hippocampus . Positive_regulation MAPK10 GRIK2 21757544 2472113 Neuroprotective role of PrPC against kainate induced epileptic seizures and cell death depends on the modulation of [JNK3] *activation* by binding . Positive_regulation MAPK10 HBEGF 10544013 563920 also rapidly *activated* [MAPK] and induced cyclin D1 in mid-G1 with kinetics similar to TGFalpha . Positive_regulation MAPK10 HBEGF 11171084 783791 Both p42 [MAPK] activation and mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation MAPK10 HBEGF 15380451 1298477 *induced* phosphorylation of ERK , p38 [MAPK] and Akt , which were suppressed by ZD1839 . Positive_regulation MAPK10 HBEGF 17928891 1858621 We report that cellular stress with methyl-beta-cyclodextrin ( MBCD ) , a molecule that extracts membrane cholesterol and thereby disrupts the structure of lipid rafts , strongly *induces* the synthesis of ( HB-EGF ) in keratinocytes through the activation of p38 [mitogen activated protein kinase] . Positive_regulation MAPK10 HBEGF 18990151 2028920 *Activation* of [Erk/MAPK] by was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation MAPK10 HBEGF 19048624 2023713 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked MAPK signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 [MAPK] , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Positive_regulation MAPK10 HBEGF 19559571 2110501 *induced* phosphorylation of p42/p44 [MAPK] in a few minutes . Positive_regulation MAPK10 HBEGF 20739666 2345886 Moreover , *induced* a stronger and more sustained activation of both the [mitogen activated protein kinase] and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation MAPK10 HBEGF 24188029 2921096 Here , we show that *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , [Mapk/Erk] pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation MAPK10 HRH1 11959800 931438 1. Previous studies have shown that the *activates* p42/p44 [mitogen activated protein kinases (MAPK)] in DDT ( 1 ) MF-2 smooth muscle cells via a phosphatidylinositol 3-kinase (PI-3K) dependent pathway . Positive_regulation MAPK10 HRH1 17965772 1820336 is *required* for TCR mediated p38 [MAPK] activation and optimal IFN-gamma production in mice . Positive_regulation MAPK10 HRH1 17965772 1820350 Moreover , signaling at the time of TCR ligation was *required* for activation of p38 [MAPK] , a known regulator of IFN-gamma expression . Positive_regulation MAPK10 IFI27 16953232 1682569 RET2A mediated regulation of p18 and , but not of cyclins D1 and D2 , *requires* functional [mitogen activated protein kinase] signaling . Positive_regulation MAPK10 IFI27 18513991 1928406 Growth arrest *induced* the expression of [JNK3] on transcriptional and translational level , whereas the expression of the cell cycle inhibitor was induced on the translational level only . Positive_regulation MAPK10 IL1B 10640438 577498 and TNF alpha also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK10 IL1B 10704772 673002 CPI-1189 inhibits *induced* [p38-mitogen activated protein kinase] phosphorylation : an explanation for its neuroprotective properties ? Positive_regulation MAPK10 IL1B 10775561 686641 *activated* p44/42 [MAPK] , and this activation was enhanced in the presence of N-acetyl-L-cysteine . Positive_regulation MAPK10 IL1B 10864897 705720 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK10 IL1B 10864897 705772 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by TNF-alpha and . Positive_regulation MAPK10 IL1B 10864897 705795 TNF-alpha- and *induced* [ ( 3 ) H ] -thymidine incorporation and phosphorylation of p42/p44 [MAPK] was completely inhibited by PD98059 ( an inhibitor of MEK1/2 ) , indicating that activation of MEK1/2 was required for these responses . Positive_regulation MAPK10 IL1B 10969830 728483 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Positive_regulation MAPK10 IL1B 11032891 740451 *induces* p38 [MAPK] phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation MAPK10 IL1B 11037878 741238 also *stimulated* phosphorylation of p38 [MAPK] , SAPK/JNK , and ATF-2 . Positive_regulation MAPK10 IL1B 11126408 759770 TNFalpha and IFNgamma potentiate *induced* [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK10 IL1B 11126408 759783 [Mitogen activated protein kinase (MAPK)] activity that is *induced* by has been suggested to signal nitric oxide dependent as well as nitric oxide independent beta-cell destructive pathways . Positive_regulation MAPK10 IL1B 11126408 759796 The aim of this study was to investigate if TNFalpha and IFNgamma signal through mitogen activated protein kinases in isolated rat islets of Langerhans and if they potentiate [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK10 IL1B 11126408 759809 Further , TNFalpha and IFNgamma were found to synergistically increase [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK10 IL1B 11399523 824257 Glucose potentiates *induced* p38 [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK10 IL1B 11509550 848353 Although and TNF-alpha each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK10 IL1B 11557585 861400 *activated* the three [mitogen activated protein kinase] ( extracellular signal regulated kinases 1 and 2 , c-Jun NH2-terminal kinase/stress activated protein kinase , and p38 ) and the Janus kinase (JAK)-signal transducer and activator of transcription pathways . Positive_regulation MAPK10 IL1B 11698472 878049 *induced* phosphorylation and activation of p38 [MAPK] and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation MAPK10 IL1B 11698472 878095 *induced* phosphorylation of ERK and JNK as well as p38 [MAPK] in human endothelial cells . Positive_regulation MAPK10 IL1B 11728947 884806 We showed a dramatic decrease in *induced* phosphorylation of p38 [MAPK] , not extracellular signal regulated kinases 1/2 or jun NH2-terminal kinase , in rat cultured mesangial cells by FR167653 . Positive_regulation MAPK10 IL1B 11775830 766434 Role of protein tyrosine kinase in *induced* activation of [mitogen activated protein kinase] in fibroblast-like synoviocytes of rheumatoid arthritis . Positive_regulation MAPK10 IL1B 11853544 913368 Interestingly , *induced* p38 [MAPK] activity was greatly enhanced in ( alg+ ) compared with ( alg- ) cells . Positive_regulation MAPK10 IL1B 12117921 964662 mRNA expression by neutrophils was not dependent on p38 MAPK , and p38 [MAPK] was not *activated* in neutrophils incubated with A. phagocytophila . Positive_regulation MAPK10 IL1B 12131776 966853 and TNF-alpha *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK10 IL1B 12139924 969393 Regarding intracellular signaling , *activated* the p38 [mitogen activated protein kinase (MAPK)] but not the p42/p44 MAPK and , when combined with growth factors , intensified p38 activation but inhibited the growth-factor induced p42/p44 activation . Positive_regulation MAPK10 IL1B 12356282 993826 induced p44/42 [mitogen activated protein kinase (MAPK)] *activation* was inhibited by the MAPK/extracellular signal regulated protein kinase ( MEK ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK10 IL1B 12417253 1012950 Sphondin ( 50 microM ) did not affect the *induced* activations of p44/42 [MAPK] , p38 MAPK , and JNK . Positive_regulation MAPK10 IL1B 12500176 1026684 These data suggest that the presence of retinal holes and may *lead* to activation of HGF , [mitogen activated protein kinases (MAPK)] , c-jun and extracellular matrix remodeling , resulting in proliferative and migratory cells in the wounded retina . Positive_regulation MAPK10 IL1B 12507586 1038418 In this study we evaluated the role of epigallocatechin-3-gallate ( EGCG ) , a green tea polyphenol which mimics its anti-inflammatory effects , in modulating the *induced* activation of [MAPK] 's in human chondrocytes . Positive_regulation MAPK10 IL1B 12649265 1080064 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant MKK6 or p38beta2 MAPK inhibited *induced* p38 [MAPK] activation , COX-2 gene expression , and PGE2 release . Positive_regulation MAPK10 IL1B 12727980 1086554 P38 [MAPK] phosphorylation was *increased* by in nondecidualized ESC , whereas the IL-1 beta induced increase was suppressed in the decidualized cells . Positive_regulation MAPK10 IL1B 12727980 1086567 Treatment with 8-bromo-cAMP reduced *induced* phosphorylation of p38 [MAPK] in nondecidualized ESC . Positive_regulation MAPK10 IL1B 12727980 1086581 In contrast , treatment with H89 , a protein kinase A inhibitor , reversed a reduction in *induced* p38 [MAPK] phosphorylation in the decidualized cells . Positive_regulation MAPK10 IL1B 12727980 1086595 The altered property of decidualized cells is thought to be caused by attenuation of *induced* p38 [MAPK] phosphorylation in a way that involves the activation of the cAMP/protein kinase A pathway . Positive_regulation MAPK10 IL1B 12882449 1116286 NAC ( 1 mM ) also decreased the *induced* activation of p38 [MAPK] . Positive_regulation MAPK10 IL1B 12952251 1137414 Using Western-blot analysis , no effect of cAMP was found on the *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK10 IL1B 12952251 1137428 No decrease was observed in *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK10 IL1B 14563491 1154857 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Positive_regulation MAPK10 IL1B 15039421 1251229 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of , and RIP2 dependent *activation* of NF-kappaB and p38 [MAPK] mediated by the caspase recruitment domain . Positive_regulation MAPK10 IL1B 15111866 1241236 We further demonstrated that p38 [MAPK] is *activated* by and PDGF with different kinetics and that p38 MAPK is required for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation MAPK10 IL1B 15208668 1281340 *induced* the activation of extracellular signal regulated kinases-1/2 and P38 [mitogen activated protein kinase (MAPK)] , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation MAPK10 IL1B 15341531 1291758 In accordance with these findings , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) , which was attenuated by U0126 , SB202190 , or SP600125 , respectively . Positive_regulation MAPK10 IL1B 15389584 1354316 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] and JNK which was attenuated by pretreatment with U0126 or SP600125 , respectively . Positive_regulation MAPK10 IL1B 15489374 1359420 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and JNK was attenuated by pretreatment with U0126 , SB-202190 , or SP-600125 , respectively . Positive_regulation MAPK10 IL1B 15755725 1403418 The inhibitory effect of on alpha ENaC expression was *mediated* by the activation of p38 [MAPK] in both rat and human ATII cells and was independent of the activation of alpha v beta6 integrin and transforming growth factor-beta . Positive_regulation MAPK10 IL1B 16033422 1436162 Intrathecal *leads* to a time dependent up-regulation of phosphorylated p38 ( p-p38 ) [MAPK] protein expression in the spinal cord 30-240 min following IL-1beta injection ( i.t. ) . Positive_regulation MAPK10 IL1B 16033422 1436176 However , pretreatment with a p38 MAPK inhibitor significantly reduced the *induced* p-p38 [MAPK] expression by 38-49 % , and nearly completely blocked the subsequent iNOS expression ( reduction by 86.6 % ) , NO production , and thermal hyperalgesia . Positive_regulation MAPK10 IL1B 16043966 1459738 Western blot analysis demonstrated that *increased* the activation of phosphorylated MEK and p38 [MAPK] in GH3 cells . Positive_regulation MAPK10 IL1B 16140882 1450802 *induced* phosphorylation of [p38-MAPK] , but not that of c-Jun-N-terminal kinase or extracellular regulated kinase , was most susceptible to inhibition by low doses of PFE , and the addition of PFE blocked the activity of p38-MAPK in a kinase activity assay . Positive_regulation MAPK10 IL1B 16141635 1454866 DHA stimulated both rapid and prolonged activation of p44/42 , but not p38 , [mitogen activated protein kinase (MAPK)] *induced* by and PMA . Positive_regulation MAPK10 IL1B 16153910 1455431 The kidney was analyzed for expression of tumor necrosis factor alpha , , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 [mitogen activated protein kinase] , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation MAPK10 IL1B 16452991 1611731 Western blots showed that and TNF-alpha *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK10 IL1B 16528573 1549425 The aim of this study was to investigate if Gadd45b prevents *induced* beta cell [MAPK] signalling and apoptosis . Positive_regulation MAPK10 IL1B 16645161 1604674 significantly *increased* the phosphorylation of p38 [MAPK] and cPLA(2) . Positive_regulation MAPK10 IL1B 16698013 1575651 JST ( 0.01-1 mg/ml ) also attenuated the expression of cyclooxygenase (COX)-2 and activation of p38 [MAPK] *induced* by and A beta ( 1-42 ) . Positive_regulation MAPK10 IL1B 16718462 1584906 A synthetic peptide , C3d , reported to bind NCAM , did not activate MAPK or Akt as reported in neurons but inhibited *induced* [MAPK] activity , thereby mimicking the effect of SU5402 . Positive_regulation MAPK10 IL1B 16718462 1584931 We suggest that NCAM signalling through FGFR is required for efficient IL-1beta pro-apoptotic signalling by facilitating induced [MAPK] *activation* downstream of the NF-kappaB-MAPK branching point . Positive_regulation MAPK10 IL1B 16718462 1584960 Further , these data identify a novel function of C3d as an inhibitor of NCAM induced FGFR activity and of *induced* [MAPK] activation in beta cells . Positive_regulation MAPK10 IL1B 16959849 1639695 *caused* an increase in the phosphorylation of ERK , but not [p38MAPK] or c-Jun N-terminal kinase . Positive_regulation MAPK10 IL1B 16964394 1611551 Inhibitors of p38 [MAPK] and/or JNK significantly suppressed VEGF secretion both in the *presence* and absence of , while inhibitors of COX-2 , ERK1/2 , and PI3-K did not . Positive_regulation MAPK10 IL1B 17208222 1695810 Thalidomide also suppressed induced p38 [mitogen activated protein kinase (MAPK)] *activation* , while a p38 MAPK inhibitor destabilized COX-2 mRNA and the cytoplasmic shuttling of HuR induced by IL-1beta . Positive_regulation MAPK10 IL1B 17311279 1719287 *stimulated* phosphorylation of p42/p44 [MAPK] , p38 MAPK , and JNK was attenuated by pretreatment with U0126 , SB202190 , SP600125 , or transfection with these dominant negative mutants of MEK , ERK , p38 and JNK , respectively . Positive_regulation MAPK10 IL1B 17390080 1716128 We have previously demonstrated that *induced* HBD-2 mRNA expression in A549 cells through activation of nuclear factor-kappaB (NF-kappaB) transcriptional factor as well as p38 [mitogen activated protein kinase (MAPK)] , c-Jun N-terminal kinase (JNK) , or phosphatidylinositol-3-kinase (PI3K) . Positive_regulation MAPK10 IL1B 17390080 1716159 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Positive_regulation MAPK10 IL1B 17390080 1716189 Triptolide inhibited *induced* [MAPK] phosphatase-1 expression at the transcriptional level and resulted in sustained phosphorylation of JNK or p38 MAPK , explaining the little effect of triptolide on IL-1beta induced phosphorylation of these kinases . Positive_regulation MAPK10 IL1B 17438131 1742768 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by TNF-alpha and , but not by ansiomycin or sorbitol . Positive_regulation MAPK10 IL1B 17559635 1753259 also *activated* extracellular signal regulated kinase , p38 [MAPK] , and c-Jun N-terminal kinase . Positive_regulation MAPK10 IL1B 17645739 1793267 Interestingly , Dex attenuated *mediated* activation of p38 [MAPK] and JNK , but not of AKT . Positive_regulation MAPK10 IL1B 17694686 1782101 IL-1beta induced NO levels and thermal hyperalgesia in rats , likely via either inhibiting the mediated p38 [MAPK] *activation* and subsequent iNOS induction , or direct attenuation of the central iNOS activity , which therefore reduces the central sensitization of inflammatory pain . Positive_regulation MAPK10 IL1B 17920534 1804187 SA981 at a concentration of 100 microM partially inhibited *induced* phosphorylation of [p38MAPK] and Akt ( 12.0 % and 36.1 % inhibition of each total amount of phosphoprotein under IL-1beta coexistence condition , respectively ) . Positive_regulation MAPK10 IL1B 17925024 1835151 *stimulated* phosphorylation of c-jun amino-terminal kinase , p38 [MAPK] and extracellular signal regulated kinase-1/2 . Positive_regulation MAPK10 IL1B 18026701 1827818 Moreover , glucosamine suppressed the *induced* phosphorylation of p38 [MAPK] ( p < 0.05 at > 0.1 mM ) and the IL-1beta binding to its receptors ( p < 0.05 at 1 mM ) . Positive_regulation MAPK10 IL1B 18065201 1853660 *stimulated* activation of ERK1/2 and p38alpha [MAPK] mediates the transcriptional up-regulation of IL-6 , IL-8 and GRO-alpha in HeLa cells . Positive_regulation MAPK10 IL1B 18348730 1925312 The *activation* or inhibition of p38 [MAPK] by and/or SB203580 was analyzed by western blotting . Positive_regulation MAPK10 IL1B 18348730 1925325 *activated* the phosphorylation of p38 [MAPK] and this effect was abolished by SB203580 . Positive_regulation MAPK10 IL1B 18427719 1920720 Phosphorylated p38 ( Phos-p38 ) [mitogen activated protein kinase] was *stimulated* in SW-1353 cells by but not by HA alone . Positive_regulation MAPK10 IL1B 18556347 1965925 or leptin individually *induced* threonine/tyrosine phosphorylation of p38 [MAPK] , whereas only leptin induced tyrosine phosphorylation of JAK2 , suggesting that leptin may enhance hBD-2 production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with NF-kappaB , which is activated by IL-1beta . Positive_regulation MAPK10 IL1B 18667841 1948049 Furthermore , *induced* p38 [mitogen activated protein kinase (MAPK)] activation and upregulation of VEGF-C mRNA and protein in LLC cells was also suppressed by artemisinin or by the p38 MAPK inhibitor SB-203580 , suggesting that p38 MAPK could serve as a mediator of proinflammatory cytokine induced VEGF-C expression . Positive_regulation MAPK10 IL1B 19362079 2081456 *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 [mitogen activated protein (MAP) kinase] , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation MAPK10 IL1B 19522843 2136336 In chondrocytes , CS diminishes *induced* increases in p38 [mitogen activated protein kinase] ( p38MAPK ) and signal regulated kinase 1/2 ( Erk1/2 ) phosphorylation , and decreases nuclear factor-kappaB (NF-kappaB) nuclear translocation and as a consequence , reduces the formation of pro-inflammatory cytokines , IL-1beta and TNF-alpha , and pro-inflammatory enzymes , such as phospholipase A2 (PLA2) , cyclooxygenase 2 (COX-2) and nitric oxide synthase-2 (NOS-2) . Positive_regulation MAPK10 IL1B 19765281 2163520 Treatment with PIP-18 blocked *induced* p38 [MAPK] phosphorylation and resulted in attenuation of sPLA2-IIA and MMP mRNA transcription in RA SF cells . Positive_regulation MAPK10 IL1B 20060906 2218518 In the present study , we demonstrate that *caused* activation of p38 [mitogen activated protein kinase] and that the p38 inhibitor SB203580 significantly blocked the effect of IL-1beta on I ( NMDA-OUT ) in hippocampal CA1 neurons . Positive_regulation MAPK10 IL1B 20353947 2266459 In model 1 , a differentiation model , CLA *activation* of [MAPK] and induction of interleukin-8 (IL-8) , IL-6 , , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation MAPK10 IL1B 21659536 2455191 Distinct roles for Nod2 protein and autocrine in muramyl dipeptide *induced* [mitogen activated protein kinase] activation and cytokine secretion in human macrophages . Positive_regulation MAPK10 IL1B 24692548 2935242 At 1 h , this was responsible for the dexamethasone inhibition of *induced* [MAPK] activation and CXCL1 and CXCL2 mRNA expression , with a similar trend for CSF2 . Positive_regulation MAPK10 IL1B 9475519 486788 Of these , *activated* only [MAPK] . Positive_regulation MAPK10 IL1B 9475519 486801 In cultured rat astrocytes , *caused* activation of [MAPK] without inducing proliferation . Positive_regulation MAPK10 IL1B 9575890 502726 Our data also indicate that both insulin and IGF-I enhance *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation and SAPK activation . Positive_regulation MAPK10 IL1B 9582321 503933 Previously we reported that *induces* activation of JNK/SAPK and p38 [MAPK] with concomitant up-regulation of cyclooxygenase (Cox)-2 expression and prostaglandin E2 ( PGE2 ) synthesis . Positive_regulation MAPK10 IL1B 9614146 509326 By Western blotting with phosphospecific antibodies and by immunocomplex kinase assay , was shown to *activate* extracellular signal regulated kinase ( ERK ) 1/2 and p38 [mitogen activated protein kinase] ( p38 ) in islets and rat insulinoma cells . Positive_regulation MAPK10 IL1B 9786861 540911 We reported previously that rapidly *activates* the c-Jun NH2-terminal/stress activated protein kinases ( JNK/SAPK ) and p38 [mitogen activated protein kinase (MAPK)] and also induces Cox-2 expression and prostaglandin E2 ( PGE2 ) production . Positive_regulation MAPK10 IL1B 9786861 540957 Overexpression of the kinase-dead form of MKK3 or MKK6 demonstrated that either of these two mutant kinases inhibited *induced* p38 [MAPK] phosphorylation and Cox-2 expression but not JNK/SAPK phosphorylation and activation . Positive_regulation MAPK10 ITGB2 12600815 1099052 IL-3 , IL-5 , and GM-CSF could enhance p38 [MAPK] and NF-kappaB activity and *induce* ICAM-1 , CD11b , and expressions on eosinophils . Positive_regulation MAPK10 ITGB2 19843511 2203198 Furthermore , beta2 integrins modulated the capacity of isolated peritoneal macrophages to take up acetylated LDL and native LDL and to phagocytose apoptotic cells , possibly via *dependent* [mitogen activated protein kinase] signalling . Positive_regulation MAPK10 LBP 20615568 2309926 Despite activating NFkappaB , NOD1 ligand did not upregulate hepatocyte production of the acute phase proteins lipopolysaccharide binding protein , serum amyloid A , or soluble CD14 in cell culture supernatants , or upregulate mRNA expression of , serum amyloid A , C-reactive protein , or serum amyloid P . NOD2 ligand ( MDP ) did not *activate* hepatocytes when given alone , but did synergize with Toll-like receptor ligands , lipopolysaccharide (LPS) , and polyI : C to activate NFkappaB and [MAPK] . Positive_regulation MAPK10 MAP2K6 10050043 592919 In one set of experiments , we *inhibited* the activation of [MAPK] by pretreating cells with PD098059 , a specific inhibitor of ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAPK10 MAP2K6 10079106 595473 Although MKK3 , MKK4 , and all *activated* p38 [MAPk] in experimental models , only MKK3 was found to activate recombinant p38 MAPk in LPS treated neutrophils . Positive_regulation MAPK10 MAP2K6 10471331 641596 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Positive_regulation MAPK10 MAP2K6 10601295 574409 In addition , *activation* of p38 [MAPK] by constitutively active or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAPK10 MAP2K6 10713051 674364 Conversely , the inhibitors PD98059 and UO126 could *attenuate* EGF induced [mitogen activated protein kinase] activation , they do not affect the EGF induced mobility shift of caveolin-1 . Positive_regulation MAPK10 MAP2K6 10759527 683138 These results demonstrate that a plant can phosphorylate and *activate* [MAPK] , and that Tyr phosphorylation is critical for the catalytic activity of MAPK in plants . Positive_regulation MAPK10 MAP2K6 10816593 714744 The MAPK kinase selectively *stimulates* p38 [MAPK] and confers protection against stress induced apoptosis in cardiac myocytes . Positive_regulation MAPK10 MAP2K6 10891559 711182 MAP kinases (MAPK) in both G-1 and G-5 cells were indistinguishably phosphorylated , yet dependent [MAPK] *activation* was observed only in G-5 cells . Positive_regulation MAPK10 MAP2K6 11005808 752409 A inhibitor , PD98059 , *inhibited* heat shock ERK [MAPK] activation by > 75 % . Positive_regulation MAPK10 MAP2K6 11085935 750721 Similarly , *activation* of JNK by Ad-MKK7D and [p38-MAPK] by resulted in the increased expression of PGHS-2 . Positive_regulation MAPK10 MAP2K6 11237743 790294 The MAPK kinase ( ) inhibitor , PD98059 , *blocked* GSA stimulated [MAPK] activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Positive_regulation MAPK10 MAP2K6 11304531 826824 The *activation* of p38 [MAPK] by Galpha ( q ) and Gbetagamma was blocked by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Positive_regulation MAPK10 MAP2K6 11787422 891916 Indeed the MAPK kinase ( = ) inhibitor PD98059 *inhibits* the activation of parasite [MAPK] , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Positive_regulation MAPK10 MAP2K6 11822870 909044 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of [MAPK] pathway *inhibitors* ( inhibitors PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAPK10 MAP2K6 12009309 940802 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Positive_regulation MAPK10 MAP2K6 12203369 983208 Furthermore , PKC inhibitors or an inhibitor completely *suppressed* both TPA induced activation of [MAPK] and promotion of anchorage independent growth , but a cPKC-selective inhibitor partially suppressed TPA induced promotion of the growth . Positive_regulation MAPK10 MAP2K6 12356282 993832 IL-1beta induced p44/42 [mitogen activated protein kinase (MAPK)] activation was *inhibited* by the MAPK/extracellular signal regulated protein kinase ( ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK10 MAP2K6 12377770 1019982 These results suggest that MKK3 , rather than , *mediates* alphav integrin induced p38 [MAPK] activation . Positive_regulation MAPK10 MAP2K6 12450322 1018626 ANG II significantly increased aldosterone release , and this effect was inhibited by the LO inhibitor baicalein , as well as a specific p38 [MAPK] *inhibitor* , SB202190 , but not by PD098059 , a specific inhibitor of the ERK activator . Positive_regulation MAPK10 MAP2K6 12637559 1085456 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Positive_regulation MAPK10 MAP2K6 12659851 1073498 MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a ( MAP2K ) , which in turn *activates* a [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK10 MAP2K6 12845643 1108578 Finally , both ODQ and UO126 blocked the capacity of L-arginine to restore ERK ( 1/2 ) phosphorylation in L-NAME treated cells , demonstrating that GC and are both *required* for endogenous NO-mediated [MAPK] activation . Positive_regulation MAPK10 MAP2K6 15104236 1240291 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( ) inhibitor , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAPK10 MAP2K6 15172888 1288368 Importantly , the presence of inhibitors only at the time of the transport assay markedly *impaired* both insulin stimulated glucose uptake and [MAPK] signaling . Positive_regulation MAPK10 MAP2K6 15172888 1288469 Conversely , removal of inhibitors before the transport assay *restored* glucose uptake and [MAPK] signaling . Positive_regulation MAPK10 MAP2K6 15304546 1322496 Furthermore , *activation* of [ERK/MAPK] by the coexpression of constitutively active predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAPK10 MAP2K6 15365248 1294554 Treatment of keratinocytes with PD98059 , inhibitor , and SB20358 , p38 [MAPK] *inhibitor* , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAPK10 MAP2K6 15570612 1355550 Although the inhibitors *suppressed* [MAPK] phosphorylation in both OA- and AICAR treated oocytes , meiotic resumption was not causally linked to MAPK phosphorylation in either group . Positive_regulation MAPK10 MAP2K6 15867183 1404240 In cultured cardiac myocytes , specific *activation* of stress activated [mitogen activated protein kinase] , p38 , by upstream activator led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAPK10 MAP2K6 15879307 1411355 Conversely , constitutively active *induced* p38 [MAPK] activation that recapitulated the effects of polyphenols by inducing ERalpha phosphorylation and downstream activation of Akt , and eNOS . Positive_regulation MAPK10 MAP2K6 16157033 1455746 SB203580 , a [P38MAPK] *inhibitor* , and U0126 , a inhibitor , both completely blocked ADM mediated responses in MsC . Positive_regulation MAPK10 MAP2K6 17416211 1777861 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK10 MAP2K6 18401006 1925807 CyaA enhanced LPS induced phosphorylation of p38 [MAPK] and ERK in DC , and inhibitors of p38 MAPK , , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation MAPK10 MAP2K6 18754769 1968422 ( MKK) 3 and 6 are the main p38 [mitogen activated protein kinase] *activators* in mammals . Positive_regulation MAPK10 MAP2K6 18771907 1962667 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a inhibitor , and SB203580 , an *inhibitor* of p38 [mitogen activated protein (MAP) kinase] , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAPK10 MAP2K6 21892182 2491660 Further , we show that *activation* of p38 [MAPK] by expression of constitutively active ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAPK10 MAP2K6 22164285 2517908 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of and marked *activation* of p38 [MAPK] . Positive_regulation MAPK10 MAP2K6 22785235 2691880 TRH induced CRE promoter was inhibited by [mitogen activated protein kinase/ERK] kinase ( MEK ) inhibitor and was *increased* by overexpression of . Positive_regulation MAPK10 MAP2K6 7644477 318651 Inhibition of by PD 098059 *prevented* activation of [MAPK] and subsequent phosphorylation of MAPK substrates both in vitro and in intact cells . Positive_regulation MAPK10 MAP2K6 7822248 285584 ( MKK ) phosphorylates and *activates* [mitogen activated protein kinase (MAPK)] in response to stimulation of various eukaryotic signaling pathways . Positive_regulation MAPK10 MAP2K6 7889302 289428 2. Both nucleotides stimulate phosphorylation and *activation* of [mitogen activated protein kinase] and a biphasic phosphorylation of the up-stream . Positive_regulation MAPK10 MAP2K6 8180183 256228 This stimulation of the activator was temporally *followed* by increased activities of MEK and [MAPK] . Positive_regulation MAPK10 MAP2K6 8226933 235399 *Activation* of extracellular signal regulated kinase ( ERK ) or [mitogen activated protein kinase] by ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAPK10 MAP2K6 8394352 228229 We show that a similar activity phosphorylates and *activates* [MAPK] in both growth factor stimulated ( epidermal growth factor and thrombin ) and oncogene ( gip2 , v-src , and v-raf ) -transfected cells . Positive_regulation MAPK10 MAP2K6 8550616 346654 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Positive_regulation MAPK10 MAP2K6 8663100 368146 The [MAPK] and NHE activities induced by PMA were *inhibited* by staurosporine , a potent inhibitor for protein kinase C ( PKC ) , and by MAPK kinase ( ) inhibitor , PD98059 , but were not affected by the tyrosine kinase inhibitor genistein . Positive_regulation MAPK10 MAP2K6 8663100 368239 In contrast , both AVP induced [MAPK] and NHE activities were *inhibited* by genistein and inhibitor but were not affected by staurosporine . Positive_regulation MAPK10 MAP2K6 8816498 384283 *activates* [mitogen activated protein kinase (MAPK)] , which phosphorylates other kinases as well as transcription factors . Positive_regulation MAPK10 MAP2K6 9135064 427600 In addition to dependent [MAPK] *activation* , we provide evidence for MEK independent regulation of the MAPKs . Positive_regulation MAPK10 MAP2K6 9166761 432448 The first step in [MAPK] *activation* by must be the formation of a MEK x MAPK enzyme-substrate complex , followed by phosphorylation producing monophosphorylated MAPK ( pMAPK ) . Positive_regulation MAPK10 MAP2K6 9626658 511874 These results indicate that *mediates* the IGF-I/insulin induced p42/ p44 [MAPK] activation . Positive_regulation MAPK10 MAP2K6 9864179 582717 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of ERK , but not p38 [MAPK] , induced by G-CSF , GM-CSF , or TNF . Positive_regulation MAPK10 MMP7 16848631 1588315 and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 [mitogen activated protein kinase] activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MAPK10 MMP7 21999204 2547382 Mesothelin enhances invasion of ovarian cancer by *inducing* through [MAPK/ERK] and JNK pathways . Positive_regulation MAPK10 MUC16 11481474 843819 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a [mitogen activated protein kinase] ( Erk 1/2 ) , and *activation* of transcription . Positive_regulation MAPK10 PECAM1 18029285 1866919 In contrast , expression of Delta15 in PECAM-1-/- bEND cells *had* minimal effects on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Positive_regulation MAPK10 PGC 22105890 2599539 Our studies also revealed that overexpression of in cardiomyocytes *inhibited* basal and T3-induced p38 [MAPK] phosphorylation . Positive_regulation MAPK10 PIGR 20450283 2257145 Induction of expression in HT-29 cells *required* NF-kappaB signaling but not [MAPK] signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation MAPK10 PLAT 19436314 2107036 cerebrospinal fluid and brain parenchymal ERK [MAPK] was elevated by H/I and this upregulation was *potentiated* by , but blunted by RBC-tPA . Positive_regulation MAPK10 PLAT 21037505 2499492 Red blood blocked c-Jun-N-terminal kinase but *potentiated* p38 [mitogen activated protein kinase] upregulation after photothrombotic injury . Positive_regulation MAPK10 PLAU 10766865 684602 surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha [mitogen activated protein kinase] activity . Positive_regulation MAPK10 PLAU 15031204 1257166 In HeLa cells the dominant negative form of JNK interferes with the p42/p44 [MAPK] *activation* of the . Positive_regulation MAPK10 PLAU 15874933 1405695 Activation of the [mitogen activated protein kinases (MAPK)] , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Positive_regulation MAPK10 PLAU 15874933 1405728 Although uPA induced phosphorylation of both ERK1/2 and p38 MAPK was blocked by Galphai inhibition , inhibition of PI3K and Ras decreased the *induced* phosphorylation of ERK1/2 but not p38 [MAPK] . Positive_regulation MAPK10 PLAU 18656457 1960561 Exogenous administered at 4 h post H/I further *stimulated* ERK [MAPK] phosphorylation , which was blocked by RAP . Positive_regulation MAPK10 PLAU 9660790 517496 The receptor *mediates* tyrosine phosphorylation of focal adhesion proteins and activation of [mitogen activated protein kinase] in cultured endothelial cells . Positive_regulation MAPK10 PLAU 9660790 517509 The *induced* activation of [MAPK] was completely inhibited by genistein , but not by 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo [ 3 , 4-d ] pyrimidine , a specific inhibitor of Src family kinases . Positive_regulation MAPK10 PODXL 17616675 1769270 expression also *led* to an increase in [mitogen activated protein kinase (MAPK)] and phosphatidylinositol 3-kinase (PI3K) activity . Positive_regulation MAPK10 PODXL 17616675 1769317 These findings suggest that leads to increased in vitro migration and invasion , increased MMP expression , and *increased* activation of [MAPK] and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MAPK10 PTGER2 19233324 2072056 Further , PGE ( 2 ) , EP2A and EP4A did not increase BMP2/4 mRNA levels in RC cells , and *induced* phosphorylation of p38 [MAPK] was not eliminated by Noggin . Positive_regulation MAPK10 SLC38A3 15331357 1288002 In contrast , *stimulated* [MAPK] activation was blocked by > 80 % by dominant negative Ras but not by dominant negative Rho and Cdc42 . Positive_regulation MAPK10 SNCAIP 12639553 1068700 In addition , [MAPK] was *activated* by through Edg-1 , Sph-1-P receptor . Positive_regulation MAPK10 SPHK1 18602364 1941498 As a result , inhibition of by SKI *blocked* phosphorylation of p38 [MAPK] , showing that SPHK activation by IL-18 is an upstream signal of p38 MAPK activation . Positive_regulation MAPK10 STK39 17237610 1690226 The phosphorylation of cytoplasmic p38 [MAPK] in Akata cells was *reduced* by the inhibitor , 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperazine ( H7 ) . Positive_regulation MAPK10 TLR7 16424221 1515535 MKP-1-deficient macrophages also show enhanced constitutive and induced *activation* of p38 [MAPK] . Positive_regulation MAPK10 TLR7 23979601 2850615 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Positive_regulation MAPK10 TLR7 24879442 2940966 GIT2 terminates *induced* NF-?B and [MAPK] signaling by recruiting the deubiquitinating enzyme Cylindromatosis to inhibit the ubiquitination of TRAF6 . Positive_regulation MAPK10 TNF 10504489 648979 Pretreatment with SB203580 ( 10 microM ) had no effect on basal or TNF-alpha stimulated phosphorylation of p38 MAPK but completely abolished *stimulated* p38 [MAPK] activity . Positive_regulation MAPK10 TNF 10521481 653109 The study presented here shows that autoregulation of gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 [mitogen activated protein (MAP) kinase] activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation MAPK10 TNF 10570180 568157 Furthermore , LPS , UV irradiation , and *caused* activation of p38 [MAPK] whereas IFN-gamma did not . Positive_regulation MAPK10 TNF 10601128 574194 alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation MAPK10 TNF 10640438 577497 IL-1 beta and also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK10 TNF 10669634 665804 In this study , we show that *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation MAPK10 TNF 10753884 682339 Moreover , *stimulated* both the NF-kappaB and [mitogen activated protein (MAP) kinase] ( extracellular signal regulated kinase , c-Jun NH ( 2 ) -terminal kinase , and p38 MAP kinase ) signaling pathways in astrocytes . Positive_regulation MAPK10 TNF 10783388 707846 dependent p38 [MAPK] *activation* was detected in both Mo7e and Hut-78 cells and was blocked by the p38 MAPK inhibitor , SB203580 . Positive_regulation MAPK10 TNF 10783388 707899 SB203580 did not affect TNF-alpha signaled nuclear translocation and DNA binding activity of NF-kappaB , and inhibition of NF-kappaB function did not affect *induced* p38 [MAPK] activation , indicating that these events are not dependent on each other . Positive_regulation MAPK10 TNF 10864897 705719 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK10 TNF 10864897 705771 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by and IL-1beta . Positive_regulation MAPK10 TNF 11095634 755296 rapidly *activated* [MAPK] and increased the extent of attachment , spreading and migration on fibronectin and collagen type I ( P < 0.01 ) but not on collagen type IV . Positive_regulation MAPK10 TNF 11108246 756725 *activates* extracellular regulated kinase-1/2 ( ERK1/2 ) and [p38MAPK] . Positive_regulation MAPK10 TNF 11108836 757036 In RAW264 cells which differentiate into osteoclast-like multinucleated cells by TNF treatment alone , activation of p38 [mitogen activated protein (MAP) kinase] *induced* by murine was comparable to and independent of the receptor activator of necrosis factor-kappaB ligand . Positive_regulation MAPK10 TNF 11156586 780612 1. We have previously shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce interleukin-8 (IL-8) by human pulmonary vascular endothelial cells . Positive_regulation MAPK10 TNF 11167962 783063 It has previously been shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce cytokine , including RANTES , that N-acetylcysteine (NAC) attenuates cytokine production by human bronchial epithelial cells ( BECs ) , and that sensitivity to TNFalpha is inversely correlated with cellular redox state . Positive_regulation MAPK10 TNF 11266661 797166 However , *caused* no activation of p42/p44 [MAPK] or cytosolic phospholipase A(2) activity . Positive_regulation MAPK10 TNF 11277995 798108 *activates* extracellular regulated kinases ( ERKs ) and p38 [mitogen activated protein kinase] ( p38MAPK ) , and inhibits the expression of uncoupling protein-1 (UCP-1) and adipocyte-specific genes in rat fetal brown adipocytes . Positive_regulation MAPK10 TNF 11319753 806836 SB 203580 , a selective inhibitor of p38 MAPK , inhibited IL-1 and *induced* p38 [MAPK] activity and IL-6 production ( IC ( 50 ) s 0.3 -- 0.5 microM ) in osteoblasts and chondrocytes . Positive_regulation MAPK10 TNF 11319753 806853 In addition , IL-1 and also *activated* p38 [MAPK] in fetal rat long bones and p38 MAPK inhibitors inhibited IL-1- and TNF stimulated bone resorption in vitro in a dose dependent manner ( IC ( 50 ) s 0.3 -- 1 microM ) . Positive_regulation MAPK10 TNF 11435466 832526 However , the cytotoxic responses to daunorubicin and exogenous ceramide remain unaltered , as do the induced p42/p44 [MAPK] *activation* and CD54 expression . Positive_regulation MAPK10 TNF 11438547 843391 *activated* p38 [MAPK] and p44/p42 MAPK in wild-type but not in p60 ( -/- ) , p80 ( -/- ) , or p60 ( -/- ) p80 ( -/- ) macrophages . Positive_regulation MAPK10 TNF 11494147 846170 In this study we demonstrate that *triggers* only modest proliferation , as well as p44/p42 [mitogen activated protein kinase (MAPK)] and NF-kappaB activation , in MM.1S multiple myeloma ( MM ) cells . Positive_regulation MAPK10 TNF 11495721 846386 Furthermore , overexpression of dominant negative mutants , H-Ras-15A and Raf-N4 , significantly suppressed p42/p44 [mitogen activated protein kinase (MAPK)] activation *induced* by and PDGF-BB and attenuated the effect of TNF-alpha on BK-induced IP response , indicating that Ras and Raf may be required for activation of these kinases . Positive_regulation MAPK10 TNF 11509550 848351 Although IL-1 beta and each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK10 TNF 11592111 869655 Lipopolysaccharide (LPS) treatment of a microglial cell line ( N9 ) *induced* a time dependent activation of both p38 [mitogen activated protein kinase] ( p38 MAPK ) and nuclear factor-kappaB (NFkappaB) , with consequent increases in interleukin-1alpha (IL-1alpha) , , and nitric oxide ( NO ) production . Positive_regulation MAPK10 TNF 11694522 896411 *activated* the three mammalian [MAPK] , p44/42 , JNK , and p38 , in a distinct time- and concentration dependent manner . Positive_regulation MAPK10 TNF 11694522 896437 In conclusion , although *activates* all three known [MAPK] in human preadipocytes , only p44/42 and JNK appear to be involved in the regulation of lipolysis . Positive_regulation MAPK10 TNF 11750919 898169 Biochemical and immunocytochemical analysis showed that *activated* p38 [mitogen activated protein kinase] ( p38MAPK ) and c-Jun N-terminal kinase (JNK) but not p42/p44 MAPK . Positive_regulation MAPK10 TNF 11820362 908736 *activated* p38 [MAPK] and stimulated IL-6 secretion by MG-63 cells , and pre-incubation of cells with the p38 MAPK inhibitor abrogated TNF-alpha dependent IL-6 secretion . Positive_regulation MAPK10 TNF 11820362 908765 Transfection of IL-6 full-length and 5-deletion gene promoter reporter constructs indicated that p38 [MAPK] *activation* by enhanced IL-6 gene expression , and that the p38 MAPK-responsive region resided in the proximal 260-bp segment . Positive_regulation MAPK10 TNF 11820362 908801 In conclusion , although p38 [MAPK] *activation* by stimulates IL-6 secretion by MG-63 cells , it has opposing effects on c/EBPbeta and NFkappaB activity . Positive_regulation MAPK10 TNF 11930247 927416 The p44/42 [MAPK] activity was significantly *enhanced* by and the TNF-alpha effect was opposed by rhIL-10 . Positive_regulation MAPK10 TNF 11930247 927429 It is suggested that rhIL-10 can inhibit *induced* VSMC proliferation and phosphorylation of p44/42 [MAPK] . Positive_regulation MAPK10 TNF 12095140 960562 significantly increased permeability and *induced* p38 and ERK [MAPK] activation compared with controls ( P < 0.05 ) . Positive_regulation MAPK10 TNF 12114204 963992 *increased* the phosphorylation of p38 MAPK within 15 min. Anisomycin , an activator of p38 MAPK , increased p38 [MAPK] phosphorylation and decreased SP-A mRNA levels in a dose dependent manner . Positive_regulation MAPK10 TNF 12130576 966574 Phosphorylation of p38 [MAPK] was *induced* by RANKL , IL-1 , , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation MAPK10 TNF 12131776 966852 IL-1 beta and *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK10 TNF 12297009 991035 In this study , we examined the anti-apoptotic role of p38 [MAPK] that is *activated* by in neuronal PC12 cells . Positive_regulation MAPK10 TNF 12297009 991048 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Positive_regulation MAPK10 TNF 12393915 1025429 This model probiotic also inhibits *activation* of the pro-apoptotic [p38/mitogen activated protein kinase] by , interleukin-1alpha , or gamma-interferon . Positive_regulation MAPK10 TNF 12511413 1079028 The treatment of RAW264 cells with TSA and NaB inhibited induced nuclear translocation of NF-kappa B and sRANKL induced *activation* of p38 [mitogen activated protein kinase (MAPK)] signals . Positive_regulation MAPK10 TNF 12631113 1067613 Additional experiments examining the role of cAMP on MC fractalkine expression showed that the incubation of MCs with TNF-alpha and either db-cAMP or forskolin attenuated TNF-alpha stimulated fractalkine mRNA and protein expression , preceded by attenuation of *activated* phosphorylation of p42/44 [MAPK] , and c-Jun , but not phosphorylation of PKCzeta/iota or nuclear translocation of NF-kappaB . Positive_regulation MAPK10 TNF 12637577 1099299 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and *requires* p38 [MAPK] activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation MAPK10 TNF 12665666 1030368 This study was undertaken to examine the relationship between induced cardiomyocyte apoptosis and *activation* of p38 [mitogen activated protein kinase (MAPK)] through oxidative stress . Positive_regulation MAPK10 TNF 12665666 1030381 Corresponding to the apoptotic effect , at 10 ng/mL *caused* rapid phosphorylation of p38 [MAPK] in wild-type cardiomyocytes . Positive_regulation MAPK10 TNF 12694807 1080907 *induced* the phosphorylation of p44/p42 [mitogen activated protein (MAP) kinase] and p38 MAP kinase . Positive_regulation MAPK10 TNF 12731668 1086843 On the other hand , GM-CSF- or *induced* phosphorylation of ERK and p38 [MAPK] was unaffected by these inhibitors at the concentrations effective for the inhibition of O2- release and adherence . Positive_regulation MAPK10 TNF 12829618 1113802 However , *induced* [p38-MAPK] phosphorylation was markedly diminished in mkk3-/- vs mkk3+/+ hearts ( percent basal , 127+/-23 versus 540+/-267 , respectively , P=0.04 ) , suggesting an MKK independent activation mechanism by ischemia . Positive_regulation MAPK10 TNF 12844496 1149726 Rho inhibition decreases induced endothelial [MAPK] *activation* and monolayer permeability . Positive_regulation MAPK10 TNF 12844496 1149739 Because GTP binding proteins have been implicated in MAPK activation , we now hypothesize that the GTP binding protein Rho is a mediator of *induced* [MAPK] activation and increased endothelial permeability . Positive_regulation MAPK10 TNF 12844496 1149753 C3 transferase attenuated *induced* [MAPK] activation and blocked TNF induced endothelial permeability . Positive_regulation MAPK10 TNF 12867430 1141974 Subsequently , mediated p38 [MAPK] *activation* induced sialidase activity and CD44-HA binding . Positive_regulation MAPK10 TNF 12867430 1142103 Taken together , our results suggest that induced p38 [MAPK] *activation* may regulate the induction of functionally active HA-binding form of CD44 by activating sialidase in LPS stimulated human monocytic cells . Positive_regulation MAPK10 TNF 12881424 1116128 Importantly , does not *induce* ROS accumulation or prolonged [MAPK] activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death Positive_regulation MAPK10 TNF 12893778 1121026 We show that MKK3 and MKK6are essential for *stimulated* p38 [MAPK] activation . Positive_regulation MAPK10 TNF 12960255 1158284 To investigate a potential interplay between *induced* activation of p38 [MAPK] and NF-kappaB , the p38 MAPK inhibitor SB203580 and a dominant negative p38 MAPK mutant were used . Positive_regulation MAPK10 TNF 14516792 1147200 [MAPK] pathway *activation* via was confirmed by marked AP-1 activation detected in EMSA . Positive_regulation MAPK10 TNF 14561851 1165102 In cultured human umbilical vein endothelial cells ( HUVECs ) , and lipopolysaccharide *increased* phosphorylation of p38 [MAPK] ( P-p38 MAPK ) and increased ICAM-1 expression . Positive_regulation MAPK10 TNF 14592823 1209461 Analyzing the individual contribution of PF-4 and its costimuli in the control of these functions at the signaling level , we demonstrate that *induced* activation of p38 [mitogen activated protein (MAP) kinase] ( but not extracellular regulated kinase [ Erk ] kinases ) acts as general and essential costimulatory signal in PF-4 dependent neutrophil exocytosis . Positive_regulation MAPK10 TNF 14632659 1170647 *activated* p38 [MAPK] in DCs only at an early time-point ( 15 min ) . Positive_regulation MAPK10 TNF 14654378 1176825 These findings suggest that the pre-ischemic *activation* of [p38-MAPK] by does not contribute to cardioprotection afforded by this agent . Positive_regulation MAPK10 TNF 15002040 1265074 Consistent with the abrogation of osteoclastogenic effect of DcR3 by TNFR-Fc , DcR3 treatment can *induce* osteoclastogenic cytokine release through ERK and p38 [MAPK] signaling pathways . Positive_regulation MAPK10 TNF 15139014 1246954 The increase in release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not [mitogen activated protein kinase (MAPK)] , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation MAPK10 TNF 15191888 1295236 Treatment of endothelial cells with SphK1 siRNA suppressed *induced* increase in MCP-1 mRNA levels , MCP-1 protein secretion , and activation of p38 [MAPK] . Positive_regulation MAPK10 TNF 15212763 1262310 Interestingly , Ad5NIK , but not , *induces* RelA S536 and p38 [mitogen activated protein kinase (MAPK)] phosphorylation in IKKgamma ( -/- ) cells . Positive_regulation MAPK10 TNF 15233873 1269387 A. semen also inhibited the expression of and the *activation* of [mitogen activated protein kinase] , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation MAPK10 TNF 15240695 1270279 TNF activates Syk protein tyrosine kinase leading to induced [MAPK] *activation* , NF-kappaB activation , and apoptosis . Positive_regulation MAPK10 TNF 15240695 1270299 TNF induced Syk activation was abolished by piceatannol ( Syk-selective inhibitor ) , which led to the suppression of *induced* activation of c- JNK , p38 [MAPK] , and p44/p42 MAPK . Positive_regulation MAPK10 TNF 15240695 1270315 Jurkat cells that did not express Syk ( JCaM1 , JCaM1/lck ) showed lack of *induced* Syk , JNK , p38 MAPK , and p44/p42 [MAPK] activation , as well as TNF induced IkappaBalpha phosphorylation , IkappaBalpha degradation , and NF-kappaB activation . Positive_regulation MAPK10 TNF 15240695 1270346 Overall , our results demonstrate that Syk activation plays an essential role in *induced* activation of JNK , p38 [MAPK] , p44/p42 MAPK , NF-kappaB , and apoptosis . Positive_regulation MAPK10 TNF 15240725 1270454 p38 [MAPK] was *activated* by and oxidants in nonadherent conditions i.e. , with 10 mM EDTA . Positive_regulation MAPK10 TNF 15240725 1270468 Finally , p38 [MAPK] *activation* by was blocked by diphenylene iodonium , an inhibitor of flavoprotein oxidoreductase , and by the free radical scavenger N-acetylcystein . Positive_regulation MAPK10 TNF 15265936 1275730 Besides NF-kappa B , celecoxib also suppressed *induced* JNK , p38 [MAPK] , and ERK activation . Positive_regulation MAPK10 TNF 15290420 1278547 Halothane or isoflurane augmented the LPS- and *induced* activation of p38 [MAPK] . Positive_regulation MAPK10 TNF 15304089 1284476 DNCB , NiSO ( 4 ) and *activated* p38 [mitogen activated protein kinases (MAPK)] and c-jun N-terminal kinase ( JNK ) . Positive_regulation MAPK10 TNF 15322069 1333418 We have also investigated the phosphorylation of p42/44 [MAPK] and *upregulation* of RhoA protein by . Positive_regulation MAPK10 TNF 15452110 1341989 In contrast , induced p42/p44 [MAPK] *activation* and CD54 expression remained unaltered . Positive_regulation MAPK10 TNF 15589482 1356209 In addition , luteolin inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , IkappaB degradation , and NF-kappaB activation . Positive_regulation MAPK10 TNF 15659876 1350300 The anabolic effect of was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an extracellular regulated kinases (ERK) . Positive_regulation MAPK10 TNF 15696169 1372154 Using TCPTP-deficient fibroblasts , we show here that TCPTP regulates *induced* [MAPK] but not NF-kappaB signaling . Positive_regulation MAPK10 TNF 15696169 1372198 These results link TCPTP and Src tyrosine kinases to the selective regulation of *induced* [MAPK] signaling and identify a previously unknown mechanism for modulating inflammatory responses mediated by TNF . Positive_regulation MAPK10 TNF 15703956 1497465 *Activation* of p38 [mitogen activated protein (MAP) kinase] and phosphatidylinositol 3-kinase (PI3K) by was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation MAPK10 TNF 15792609 1386791 By stimulation of in AM-1 cells , the phosphorylation of Akt ( Ser473 ) and p44/42 [mitogen activated protein kinase (MAPK)] ( Thr202/Tyr204 ) was markedly *increased* in TNFalpha concentration and time dependent manner . Positive_regulation MAPK10 TNF 15792609 1386804 Pretreatment with U0126 , mitogen activated extracellular regulated kinase ( MEK) 1/2 inhibitor , prior to TNFalpha stimulation , specifically inhibited *induced* phosphorylation of p44/42 [MAPK] ( Thr202/Tyr204 ) in AM-1 cells . Positive_regulation MAPK10 TNF 15792609 1386820 Meanwhile , pretreatment with LY294002 , phosphatidylinositol-3-OH kinase (PI3K) inhibitor , could inhibit both *induced* phosphorylation of Akt ( Ser473 ) and p44/42 [MAPK] ( Thr202/Tyr204 ) . Positive_regulation MAPK10 TNF 15823554 1393909 Furthermore , potently *activated* p38 [MAPK] , JNK , and NF-kappaB . Positive_regulation MAPK10 TNF 15837794 1432546 Expression of this protein inhibited *induced* activation of NFkappaB , JNK , and p38 [MAPK] and sensitized the cells to TNF induced apoptosis . Positive_regulation MAPK10 TNF 15845648 1425544 *induces* a more than tenfold increase in p38 [mitogen activated protein kinase (MAPK)] but not extracellular signal regulated kinase phosphorylation . Positive_regulation MAPK10 TNF 15870903 1405544 In addition , GA inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , I kappa B alpha degradation , and NF-kappa B activation . Positive_regulation MAPK10 TNF 16009485 1441397 Moreover , p44/42 [mitogen activated protein kinase] appears to partly *mediate* the negative effect of insulin but not on ATGL . Positive_regulation MAPK10 TNF 16023081 1441585 Ellagic acid inhibited IL-1beta- and induced *activation* of activator protein-1 and mitogen activated protein kinases ( extracellular signal regulated kinase , c-Jun N-terminal kinase and p38 [mitogen activated protein kinase] ) , but not of nuclear factor-kappaB . Positive_regulation MAPK10 TNF 16025396 1435608 *activated* the phosphorylation of p44/42 MAPK , p38 [MAPK] , SAPK/JNK and Akt in mesangial cells . Positive_regulation MAPK10 TNF 16025396 1435624 PGE1 inhibited the *induced* phosphorylation of SAPK/JNK and Akt , but not p44/42 [MAPK] and p38 MAPK . Positive_regulation MAPK10 TNF 16080915 1442764 Comparative gene array analysis of *induced* [MAPK] and NF-kappaB signaling pathways between retinal ganglion cells and glial cells . Positive_regulation MAPK10 TNF 16140562 1499250 These results suggested that TNFalpha induced both cell survival and apoptosis pathways in ameloblastoma and potential of TNFalpha in inducing apoptosis can be improved by inhibiting *induced* Akt and p44/42 [mitogen activated protein kinase (MAPK)] cell survival pathways . Positive_regulation MAPK10 TNF 16275991 1480294 Angiotensin II , , or epidermal growth factor *induced* [MAPK] phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation MAPK10 TNF 16291729 1526067 *Activation* of [MAPK] and Akt by anti-HER2/neu inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation MAPK10 TNF 16314440 1486996 treatment *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation in NPCs , and SB202190 , an inhibitor of p38 MAPK , blocked TNF-alpha induced chemokine production . Positive_regulation MAPK10 TNF 16325162 1511661 Furthermore , APE1/ref-1 overexpression inhibited the *induced* increase in intracellular superoxide and p38 [MAPK] phosphorylation . Positive_regulation MAPK10 TNF 16452991 1611730 Western blots showed that IL-1beta and *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK10 TNF 16517732 1530930 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of , but not IL-6 , *requires* the activity of p38 [MAPK] . Positive_regulation MAPK10 TNF 16573652 1556133 HA-mediated production *required* p38 [MAPK] , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation MAPK10 TNF 16682409 1584054 Further , the deletion of NQO1 abolished induced c-Jun N-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] *activation* . Positive_regulation MAPK10 TNF 16781693 1585612 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and and the *activation* of [MAPK] 's are potentially positive signals for IL-10 production . Positive_regulation MAPK10 TNF 16798728 1638531 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Positive_regulation MAPK10 TNF 16875982 1593559 *activates* [p38-MAPK] , a stress-responsive kinase implicated in contractile depression and cardiac injury . Positive_regulation MAPK10 TNF 16875982 1593573 Under conditions of constant coronary flow , the [p38-MAPK] activation and contractile depression *induced* by , though attenuated , remained sensitive to the absence of MKK3 or the presence of SB203580 . Positive_regulation MAPK10 TNF 16875982 1593587 *activates* [p38-MAPK] in the intact heart and in isolated cardiac myocytes through MKK3 . Positive_regulation MAPK10 TNF 16982923 1617359 Compared with wild-type cells , MIF-deficient cells were hyporesponsive to IL-1- and *induced* [MAPK] activity , AP-1 activity , and cellular proliferation , while NF-kappaB function was preserved . Positive_regulation MAPK10 TNF 17070777 1649826 Inhibition of Syk down-regulated *induced* p38 and p44/42 [MAPK] phosphorylation and nuclear translocation of p65 NF-kappaB . Positive_regulation MAPK10 TNF 17099067 1676197 Importantly , Dex is able to increase the expression of MKP-1 , which causes an inactivation of *induced* p38 [MAPK] and mediates inhibition of E-selectin expression . Positive_regulation MAPK10 TNF 17126899 1677670 Stimulation of ECs with *induced* rapid increases in the phosphorylation of their mitogen activated protein kinases ( MAPKs ) [ extracellular signal regulated kinase ( ERK ) , c-Jun-NH2-terminal kinase (JNK) , and p38 [MAPK] ] ; Positive_regulation MAPK10 TNF 17126905 1686541 Differential regulation of and GM-CSF *induced* activation of P38 [MAPK] in neutrophils and eosinophils . Positive_regulation MAPK10 TNF 17138860 1653543 The role of delta-PKC in *mediated* activation of [MAPK] is not known . Positive_regulation MAPK10 TNF 17138860 1653569 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 MAPK are involved in TNF antiapoptotic signaling and whether delta-PKC is a key regulator of [MAPK] *activation* by . Positive_regulation MAPK10 TNF 17138860 1653595 In human neutrophils , *activated* both p38 [MAPK] and ERK1/2 principally via TNFR-1 . Positive_regulation MAPK10 TNF 17158449 1694245 A green fluorescent protein fusion protein containing the last 100 residues of TAK1 ( TAK1-C100 ) abolished the interaction of endogenous TAB2/TAB3 with TAK1 , the phosphorylation of TAK1 , and prevented the activation of IKK and [MAPK] *induced* by IL-1 , , and RANKL . Positive_regulation MAPK10 TNF 17161959 1694535 Upon examination of the signaling components , we found that was a potent *activator* of p38 , p44/42 , p54/46 [MAPK] , and IkappaBalpha ( IkappaBalpha ) . Positive_regulation MAPK10 TNF 17172975 1679383 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the [MAPK] , and production of . Positive_regulation MAPK10 TNF 17172975 1679409 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the [MAPK] , and production of . Positive_regulation MAPK10 TNF 17189827 1680159 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Positive_regulation MAPK10 TNF 17202326 1680811 Augmented lipopolysaccharide induced production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK10 TNF 17202326 1680837 In this study , we show that augmented LPS induced production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK10 TNF 17218473 1732509 The RhoA inhibitor C3 exoenzyme and the ROCK inhibitor Y-27632 both attenuated induced [MAPK] *activation* and blocked AR expression in HIMEC . Positive_regulation MAPK10 TNF 17220297 1703050 TRAF2 and ASK1 play essential roles in *induced* [mitogen activated protein kinase] signaling . Positive_regulation MAPK10 TNF 17258890 1725446 The effects of and FasL on GrB expression were specifically *mediated* by [p38MAPK] ( Mitogen-activated-protein-kinase ) activation . Positive_regulation MAPK10 TNF 17425653 1748780 The percentage increases in IL-18 induced phosphorylation of extracellular signal regulated kinase ( ERK ) in Th cells of NDN and DN were significantly higher than controls ( P < 0.05 ) , while the percentage increase in *induced* phosphorylation of p38 [MAPK] in monocytes and IL-18 induced phosphorylation of p38 MAPK in Th cells and monocytes were significantly higher in NDN patients than controls . Positive_regulation MAPK10 TNF 17438131 1742767 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation MAPK10 TNF 17438336 1749072 FAK promoted *stimulated* [MAPK] activation needed for maximal IL-6 production . Positive_regulation MAPK10 TNF 17438336 1749089 Analysis of FAK ( -/- ) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity , Tyr-397 phosphorylation , and the Pro-712/713 proline-rich region of FAK were required for *stimulated* [MAPK] activation and IL-6 production . Positive_regulation MAPK10 TNF 17446186 1749507 *increased* p38 [MAPK] phosphorylation , potently stimulated IRS-1 serine phosphorylation , and blunted insulin stimulated IRS-1 tyrosine and Akt phosphorylation and eNOS activity . Positive_regulation MAPK10 TNF 17531219 1762167 On the other hand , aloe emodin did not affect induced *activation* of p38 [mitogen activated protein kinase] or generation of reactive oxygen species . Positive_regulation MAPK10 TNF 17607712 1798186 Although *induced* the activation of p38 [MAPK] , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation MAPK10 TNF 17725582 1801631 MAC inhibited induced p38 [mitogen activated protein kinase] *activation* and cell death in cultured Schwann cells . Positive_regulation MAPK10 TNF 17895408 1823962 IA did not interfere with *induced* activation of c-Jun N-terminal kinase (JNK) and p38 [mitogen activated protein kinase] . Positive_regulation MAPK10 TNF 17942934 1814211 Deletion of NQO2 also abolished *induced* c-Jun NH2-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] activation . Positive_regulation MAPK10 TNF 17994109 1851159 triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 [MAPK] , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation MAPK10 TNF 18039275 1828525 Further downstream in this axis of signalling , blockade *reduces* only acute bronchoconstriction , while [MAPK] inhibition abrogates completely endotoxin induced inflammation . Positive_regulation MAPK10 TNF 18060043 1853599 In cultures of Schwann cells , astrocytes , and microglia , sLRP-alpha inhibited induced *activation* of p38 MAPK and [ERK/MAPK] . Positive_regulation MAPK10 TNF 18061162 1861513 We demonstrate that *induced* proliferation of C4HD murine mammary tumor cells and of T47D cells through the activation of p42/p44 [MAPK] , JNK , PI3-K/Akt pathways and nuclear factor-kappa B (NF-kappa B) transcriptional activation . Positive_regulation MAPK10 TNF 18091748 1847364 *induced* phosphorylation of extracellular signal regulated kinase ( ERK ) and Akt , but not p38 [mitogen activated protein kinase (MAPK)] , was attenuated by nicardipine , cilnidipine , benidipine , efonidipine , and azelnidipine . Positive_regulation MAPK10 TNF 18227157 1884358 It was shown that these three proteins could ( i ) induce expression of and tissue factor and ( ii ) *induce* phosphorylation of p44/42 [mitogen activated protein kinases (MAPK)] and activation of early growth response factor 1 (Egr-1) . Positive_regulation MAPK10 TNF 18258304 1884793 However , over-expression of a dominant negative form of Rac strongly inhibited induced p42/44 [MAPK] kinase *activation* , but had little effect upon JNK and no effect upon p38 MAPK activity . Positive_regulation MAPK10 TNF 18287053 1872486 Here , we show that the murine CMV M45 protein binds to RIP1 and inhibits *induced* activation of NF-kappaB , p38 [MAPK] , and caspase independent cell death . Positive_regulation MAPK10 TNF 18287248 1896522 Flavopiridol suppresses induced *activation* of activator protein-1 , c-Jun N-terminal kinase , p38 mitogen activated protein kinase (MAPK) , p44/p42 [MAPK] , and Akt , inhibits expression of antiapoptotic gene products , and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells . Positive_regulation MAPK10 TNF 18314542 1931903 P < 0.05 ) , and MKP-1 up-regulation was temporally related to the inhibition of *induced* p38 [MAPK] phosphorylation . Positive_regulation MAPK10 TNF 18336852 1912237 *stimulated* phosphorylation of p42/p44 [MAPK] and JNK were attenuated by pretreatment with the inhibitors U0126 and SP600125 or transfection with dominant negative mutants of DeltaERK and DeltaJNK . Positive_regulation MAPK10 TNF 18364436 1912765 We , for the first time , demonstrate that binding of staphylococcal enterotoxin B to MHC-II results in activation of TNF-alpha converting enzyme , epidermal growth factor receptor , [p38MAPK] , and NF-kappaB *inducing* biphasic production . Positive_regulation MAPK10 TNF 18443205 1938523 Conversely , *induced* increases in insulin receptor substrate-1 serine phosphorylation ( Ser ( 312 ) ) , Jun NH ( 2 ) -terminal kinase phosphorylation , and extracellular signal related kinase-1/2 [mitogen activated protein kinase (MAPK)] phosphorylation were unaltered by siRNA mediated IKKbeta reduction . Positive_regulation MAPK10 TNF 18518937 1971917 Although Cot/Tpl2 was phosphorylated in IRI and in the cultured tubular epithelial cells (TEC) after stimulation with LPS and hydrogen peroxide , there were no significant differences in terms of production , neutrophil infiltration or [MAPK] *activation* between Cot/Tpl2 ( +/+ ) and Cot/Tpl2 ( -/- ) mice . Positive_regulation MAPK10 TNF 18636175 1937267 Furthermore , glucosamine inhibited the *induced* phosphorylation of [p38MAPK] and NF-kappaB p65 , and the nuclear translocation of NF-kappaB in the cells . Positive_regulation MAPK10 TNF 18653803 1960514 PMA stimulated nSMase2 translocation was independent of p38 MAPK , and neither PKC inhibitors nor small interfering RNA had significant effects on *stimulated* p38 [MAPK] activation , indicating that PKC-delta does not act through p38 MAPK in regulating nSMase2 . Positive_regulation MAPK10 TNF 18710428 2028198 As for the signalling pathway , stimulation *led* to the phosphorylation of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and translocation of nuclear factor kappaB (NF-kappaB) ( p65 ) into the nuclei . Positive_regulation MAPK10 TNF 18710428 2028217 These data suggest that interaction *leads* to the phosphorylation of Erk1/2 and [p38MAPK] and nuclear translocation of NF-kappaB , which is closely associated with the production and activation of MMP-9 in cultured CC cells of HuCTT-1 and CCKS-1 . Positive_regulation MAPK10 TNF 18768892 1957210 Consistently , Nod2-null macrophages tolerant to LPS and MDP showed enhanced production of and IL-6 as well as increased NF-kappaB and [MAPK] *activation* in response to the dipeptide KF1B , the Nod1 agonist . Positive_regulation MAPK10 TNF 18948845 2053237 Hypertonic saline did not alter *induced* p38 [mitogen activated protein kinase] phosphorylation or constitutive vascular endothelial growth factor expression , suggesting that the observed inhibition is not a generalized suppression of protein phosphorylation or cellular function . Positive_regulation MAPK10 TNF 19100731 2031218 at 30 ng/ml significantly *increased* phosphorylation of receptor tyrosine kinase ( 175 kDa ) and p42 [mitogen activated protein (MAP) kinase] . Positive_regulation MAPK10 TNF 19130554 2025297 Stimulation of HIMEC with *triggered* phosphorylation of the [MAPK] , and up-regulation of VCAM-1 , FKN and ICAM-1 . Positive_regulation MAPK10 TNF 19234337 2079507 Analysis of downstream signals showed that inhibition of NAD(P)H oxidase partially inhibited NF-kappaB activation but did not reduce CCL2 mRNA stability or prevent *induced* phosphorylation of [p38MAPK] . Positive_regulation MAPK10 TNF 19275968 2072841 *stimulated* the phosphorylation levels of p38 [MAPK] , JNK , ERK1/2 and Akt in vascular endothelial cells . Positive_regulation MAPK10 TNF 19289468 2073035 The requirement for MADD was highly specific for *induced* activation of [MAPK] but not the related JNK and p38 kinases . Positive_regulation MAPK10 TNF 19371952 2081759 Of note , the IFN-gamma plus *stimulated* activation of p38 [MAPK] was suppressed following incubation with forskolin or DBcAMP alone . Positive_regulation MAPK10 TNF 19410630 2089692 By transfection of TAK1 siRNA , *induced* phosphorylation of IkappaBalpha , JNK1/2 , and [p38MAPK] , as well as IL-6 or IL-8 expression , were repressed . Positive_regulation MAPK10 TNF 19427347 2106791 *induced* the phosphorylation of p38 [mitogen activated protein (MAP) kinase] , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation MAPK10 TNF 19429670 2106857 Ang II and clearly *enhanced* ERK and [p38MAPK] phosphorylation . Positive_regulation MAPK10 TNF 19563733 2122005 Finally , EZS inhibited *induced* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phosphorylation . Positive_regulation MAPK10 TNF 19648110 2138328 This correlates with reduced *stimulated* p38 [MAPK] phosphorylation . Positive_regulation MAPK10 TNF 19648110 2138343 Repression of *induced* p38 [MAPK] phosphorylation , NF-kappaB dependent transcription , and IL-8 expression by dexamethasone are sensitive to transcriptional or translational inhibitors . Positive_regulation MAPK10 TNF 19648110 2138414 Thus , MKP-1 attenuates dependent *activation* of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Positive_regulation MAPK10 TNF 19648110 2138441 Small interfering RNA knockdown of dexamethasone induced MKP-1 expression partially reverses the repression of *activated* p38 [MAPK] , demonstrating that MKP-1 participates in the dexamethasone dependent repression of this pathway . Positive_regulation MAPK10 TNF 19788916 2163919 Tumor necrosis factor ( ) and H ( 2 ) O ( 2 ) *activate* [mitogen activated protein kinase (MAPK)] in SH-SY5Y cells within 5 min and this activation is completely blocked by DLPC ( 12 microM ) . Positive_regulation MAPK10 TNF 19877072 2160708 CpdA also displayed profound effects on *induced* [MAPK] activation . Positive_regulation MAPK10 TNF 19877072 2160725 In sharp contrast , DEX did not affect induced IKK phosphorylation , IkappaBalpha degradation , p65 nuclear translocation , or [MAPK] *activation* in RA FLS . Positive_regulation MAPK10 TNF 19889458 2197300 Calpain inhibition induces random migration in TNF-alpha stimulated cells and prevents the generation of reactive oxygen species , but does not alter *mediated* activation of p38 MAPK and ERK [MAPK] . Positive_regulation MAPK10 TNF 20231691 2237855 TNF-alpha treatment resulted in the phosphorylation of p38 MAPK and its downstream target , MAPK activated protein kinase-2 , but IFN-gamma did not affect the levels of [MAPK] and MAPK activated protein kinase-2 phosphorylation *induced* by . Positive_regulation MAPK10 TNF 20489729 2327417 *induced* activation of p38 [MAPK] and the production of inducible nitric oxide synthase were suppressed in ASK1-deficient Müller glial cells . Positive_regulation MAPK10 TNF 20646342 2292546 Effects of budesonide on P38 [MAPK] activation , apoptosis and IL-8 secretion , *induced* by and Haemophilus influenzae in human bronchial epithelial cells . Positive_regulation MAPK10 TNF 20646342 2292574 induced a significant *increase* in p38 [MAPK] phosphorylation . Positive_regulation MAPK10 TNF 20693316 2351475 In four of the six donors , basal and *induced* ERK and p38 [MAPK] activation were higher in ASMA than ASMNA cells . Positive_regulation MAPK10 TNF 20696856 2351506 Surprisingly , replenishment with exogenous GSH normalizes both *dependent* NF-?B as well as [MAPK] signaling and rescues hepatocytes from FKB induced death . Positive_regulation MAPK10 TNF 20951126 2364947 Taken together , this study provided first evidence demonstrating that TRAIL- , , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK10 TNF 21123734 2377719 The ability of CO to inhibit *induced* ERK1/2 and p38 [MAPK] activities in an Akt dependent manner appears to be the key element in ROS dependent survival of endothelial cells during TNF-a mediated brain inflammatory disease . Positive_regulation MAPK10 TNF 21181166 2499603 IL-1ß and *activated* the intracellular mitogen activated protein kinases ( MAPKs ) : p44/42 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) as well as nuclear factor-?B ( NF-?B ) in osteoblasts . Positive_regulation MAPK10 TNF 21285293 2425718 Inhibitors of NADPH oxidase and/or p47phox siRNA diminished ROS production and COX-2 expression as well as phosphorylation of p38 [mitogen activated protein kinase] ( p38MAPK ) and Akt *mediated* either by AS serum or by . Positive_regulation MAPK10 TNF 21336587 2457986 Effects of preconditioning with sevoflurane on *induced* permeability and activation of p38 [MAPK] in rat pulmonary microvascular endothelial cells . Positive_regulation MAPK10 TNF 21422246 2416765 Interestingly , all PHA-L ( high ) DCs displayed a strongly reduced responsiveness to induced [p38-MAPK] *activation* compared with PHA-L ( low ) DCs , indicating differences in PHA-L binding capacities between DCs with different inflammatory properties . Positive_regulation MAPK10 TNF 21422246 2416779 Moreover , hybrid-type , but not complex-type , N-glycans are required for *induced* [p38-MAPK] activation and subsequent phenotypic maturation of BMDCs ( MHC-II , CD86 , CCR7 upregulation ) . Positive_regulation MAPK10 TNF 21520062 2423118 Here , we report that *induced* cPLA(2) protein and mRNA expression , PGE ( 2 ) production , and phosphorylation of p42/p44 MAPK , p38 [MAPK] , and JNK1/2 , which were attenuated by pretreatment with a ROS scavenger [ N-acetyl-L-cysteine , ( NAC ) ] and the inhibitors of NADPH oxidase [ apocynin (APO) and diphenyleneiodonium chloride ( DPI ) ] , MEK1/2 ( U0126 ) , p38 MAPK ( SB202190 ) , and JNK1/2 ( SP600125 ) or transfection with siRNA of Nox2 , p47(phox) , MEK1 , p42 , p38 , or JNK2 . Positive_regulation MAPK10 TNF 21545687 2554377 significantly *induced* phosphorylation of p38 [MAPK] , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation MAPK10 TNF 21894146 2510861 Vehicle and untreated NTN exhibited heavy proteinuria and glomerular thrombosis at 24 h with P-selectin and fibrin immunostaining within capillaries , glomerular macrophage and T cell infiltration , *activation* of JNK and p38 [MAPK] signalling , and upregulation of glomerular mRNA levels of pro-inflammatory molecules ( , NOS2 , MMP-12 and CCL2 ) . Positive_regulation MAPK10 TNF 22002864 2526324 These results suggest that H ( 2 ) O ( 2 ) -induced secretion of *increases* apoptosis of cardiac myocytes through ROS dependent activation of p38 [MAPK] . Positive_regulation MAPK10 TNF 22227193 2544573 Casuarinin significantly inhibited *induced* activation of NF-?B , STAT1 , and p38 [MAPK] . Positive_regulation MAPK10 TNF 22230399 2519473 KMUP-1 inhibited *induced* iNOS and U46619 induced PDE-5A and phospho-p38 [MAPK] in normoxia , confirming its anti-proinflammatory action . Positive_regulation MAPK10 TNF 22250084 2551208 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Positive_regulation MAPK10 TNF 22343222 2617805 Using immunohistological techniques , we showed a higher epithelial expression of , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator [protein-1/mitogen activated protein kinase] signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation MAPK10 TNF 22525504 2522569 *up-regulated* the phosphorylation levels of p38 [MAPK] and increased the translocation of NF-kB p65 protein into the nucleus , also proved by immunofluorescence staining . Positive_regulation MAPK10 TNF 22526394 2595910 also *increased* the production of inducible nitric oxide synthase (iNOS) , nitric oxide ( NO ) , and intercellular adhesion molecule 1 ( ICAM-1 ) through activation of p38 [mitogen activated protein kinase (MAPK)] from HT-29 cells . Positive_regulation MAPK10 TNF 22773691 2659899 *induced* activation of p38 [MAPK] and NF-?B was attenuated by miR-140-3p mimic . Positive_regulation MAPK10 TNF 22819264 2646092 CORM-2 inhibited *induced* activation of p38 [MAPK] , ERK1/2 , JNK , and NF-?B signaling pathways in HUVECs . Positive_regulation MAPK10 TNF 22947346 2678658 *induced* phosphorylated p38 [mitogen activated protein kinase] levels were increased in ASMCs from patients with severe asthma compared with those from patients with nonsevere asthma and nonasthmatic subjects , whereas TNF-a induced phosphorylated c-Jun N-terminal kinase and phosphorylated extracellular signal related kinase levels were increased in all asthmatic groups . Positive_regulation MAPK10 TNF 22988345 2674352 The EGF receptor and HER2 participate in *dependent* [MAPK] activation and IL-8 secretion in intestinal epithelial cells . Positive_regulation MAPK10 TNF 22988345 2674380 As the epidermal growth factor receptor (EGFR) is a known transducer of proliferative signals and a potent activator of MAPKs , we hypothesized that the EGFR participates in *dependent* [MAPK] activation and IL-8 secretion by intestinal epithelial cells ( IECs ) . Positive_regulation MAPK10 TNF 23071098 2720899 Mixed-effects modeling analysis of our data was vital for ascertaining that IL-1a and TGF-a treatment increased the activities of more pathways than IL-6 and TNF-a and that TGF-a and *increased* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phospho-protein levels in a synergistic manner . Positive_regulation MAPK10 TNF 23142559 2722783 Western blot analysis revealed that pilocarpine and physostigmine enhanced the *induced* phosphorylation of ERK1/2 and p38 [MAPK] and the degradation of I?Ba . Positive_regulation MAPK10 TNF 23333920 2758381 Interestingly , IL-27 promoted the basal and enhanced *induced* phosphorylation of p38 [MAPK] and Akt , but not I?Ba . Positive_regulation MAPK10 TNF 23353699 2754237 We further demonstrated that markedly *stimulated* p38 MAPK , p42/p44 [MAPK] , and JNK1/2 phosphorylation via a c-Src/EGFR , PDGFR/PI3K/Akt pathway . Positive_regulation MAPK10 TNF 23354775 2770359 p38a [mitogen activated protein kinases (MAPK)] may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , , interleukin-1ß , and oxidative stress . Positive_regulation MAPK10 TNF 23664593 2838380 sFGL2 secretion by CD4 ( + ) T cells can be *induced* with and IFN-? stimulation through [MAPK] signaling in renal allograft AR . Positive_regulation MAPK10 TNF 23861542 2817209 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Positive_regulation MAPK10 TNF 23884101 2821465 Furthermore , P. vulgaris extract suppressed *induced* phosphorylation of p38 [mitogen activated protein kinase (MAPK)] and extracellular signal regulated kinase ( ERK ) . Positive_regulation MAPK10 TNF 23935096 2840759 In contrast , loss of SK1 prevented *induced* phosphorylation of p38 [MAPK] , and inhibition of p38 MAPK , like SK1 knockdown , also potentiates RANTES induction . Positive_regulation MAPK10 TNF 24069158 2846990 We showed that markedly *stimulated* p42/p44 [MAPK] , p38 MAPK , and JNK1/2 phosphorylation which were attenuated by their respective inhibitors . Positive_regulation MAPK10 TNF 24080497 2902536 Consistently , DUSP1 promotes apoptosis and decreases NF-?B activity in cells in which p38 [MAPK] is *induced* by treatment . Positive_regulation MAPK10 TNF 24089494 2848147 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed receptor 1 and *requires* activation of p38 [MAPK] , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation MAPK10 TNF 24361597 2911242 We further demonstrated that *stimulated* ERK1/2 , p38 [MAPK] , and JNK1/2 phosphorylation via a c-Src dependent PDGFR/PI3K/Akt pathway . Positive_regulation MAPK10 TNF 24378531 2911770 TRAF2 has been previously reported to be required for *induced* activation of p38 [MAPK] . Positive_regulation MAPK10 TNF 24441870 2922930 We showed that markedly *stimulated* Jak2 , PDGFR , Akt , and p42/p44 [MAPK] phosphorylation , which were attenuated by their respective inhibitors . Positive_regulation MAPK10 TNF 24441870 2922948 In addition , *induced* p42/p44 [MAPK] phosphorylation was reduced by AG1296 or LY294002 . Positive_regulation MAPK10 TNF 24441870 2922984 On the other hand , could *induce* Akt and p42/p44 [MAPK] translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation MAPK10 TNF 24446489 2912935 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Positive_regulation MAPK10 TNF 24489443 2884789 Finally , by investigating the intracellular pathways involved in promoting the VEC release of cytokines/chemokines , which are targeted by natural anti-inflammatory compounds , we documented that aLipoic acid significantly counteracted *induced* NF-?B and [p38/MAPK] activation while the effects of Ginkgo biloba appeared to be predominantly mediated by Akt . Positive_regulation MAPK10 TNF 24750790 2936560 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas and NO production *required* all three [MAPK] . Positive_regulation MAPK10 TNF 7689564 225761 *induced* activation and increased tyrosine phosphorylation of [mitogen activated protein (MAP) kinase] in human fibroblasts . Positive_regulation MAPK10 TNF 7689564 225774 *induced* activation of [MAPK] was demonstrated by its enhanced ability to phosphorylate myelin basic protein in vitro and by a characteristic shift in the electrophoretic mobility of MAPK proteins . Positive_regulation MAPK10 TNF 7722327 301754 *induces* tyrosine phosphorylation of [mitogen activated protein kinase] in adherent human neutrophils . Positive_regulation MAPK10 TNF 7722327 301780 PMN pretreatment with genistein , a tyrosine kinase inhibitor , inhibited the *induced* increase in tyrosine phosphorylation and [MAPK] activity . Positive_regulation MAPK10 TNF 8626494 360273 Inhibition of induced p42/p44 [mitogen activated protein kinase] *activation* by sodium salicylate . Positive_regulation MAPK10 TNF 8626494 360287 *activates* both p42 and p44 [mitogen activated protein kinases (MAPK)] in human FS-4 fibroblasts , cells for which TNF is mitogenic . Positive_regulation MAPK10 TNF 8626494 360300 We now show that *activates* p42 [MAPK] in two cell lines whose growth is inhibited by TNF . Positive_regulation MAPK10 TNF 8626494 360315 We now show that neither phorbol ester-sensitive protein kinase C nor Gialpha link TNF to p42/p44 MAPK activation , because pretreatment of FS-4 cells with phorbol ester to down-regulate protein kinase C or pretreatment with pertussis toxin to block Gialpha does not inhibit p42/p44 [MAPK] *activation* by . Positive_regulation MAPK10 TNF 8626494 360334 To further analyze MAPK activation in FS-4 cells , we compared p42/p44 [MAPK] *activation* by and epidermal growth factor (EGF) . Positive_regulation MAPK10 TNF 8626494 360360 Elucidation of the mechanism whereby sodium salicylate blocks *induced* p42/p44 [MAPK] activation may help to clarify TNF activated signaling pathways . Positive_regulation MAPK10 TNF 8662702 367179 additionally *caused* rapid p38 and JNK-1 [mitogen activated protein kinase] activation and efficient NF-kappaB translocation , which could not be achieved even by high levels of ceramide . Positive_regulation MAPK10 TNF 9106254 424407 The increases in [MAPK] *induced* by and IL-1 were similar to the increases induced by PMA and PDGF-AB . Positive_regulation MAPK10 TNF 9106254 424433 Our findings indicate that and IL-1 activate parallel signal transduction pathways in human neuroma fibroblasts , and that they are relatively stronger *activators* of [MAPK] than of SAPK . Positive_regulation MAPK10 TNF 9315666 456097 , an inhibitor of insulin stimulated adipogenesis , *activated* [MAPK] in 3T3-L1 cells . Positive_regulation MAPK10 TNF 9439626 482866 *increased* ERK1 and ERK2 [MAPK] phosphorylation . Positive_regulation MAPK10 TNF 9439626 482892 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic effect of *requires* protein tyrosine phosphorylation and [MAPK] activation . Positive_regulation MAPK10 TNF 9593119 505482 The CAZ released endotoxin was similar to purified LPS with respect to the following biological activities in LPS-responsive C3H/HeN mice and LPS-hyporesponsive C3H/HeJ mice : lethal toxicity in GalN sensitized mice , in vitro induction of and NO production by macrophages , and [mitogen activated protein kinase] *activation* in macrophages . Positive_regulation MAPK10 TNF 9766635 538502 Our data suggest that and GM-CSF *activate* ERKs and p38 [MAPK] by different signal transduction pathways . Positive_regulation MAPK10 TNF 9770326 538799 Furthermore , *induction* of p42/p44 ERK and [p38-MAPK] phosphorylation , c-jun kinase activation , and IkappaBalpha degradation were normal . Positive_regulation MAPK10 TNF 9883899 558205 *Activation* of p42/p44 mitogen activated protein kinases (MAPK) and p38 [MAPK] by is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation MAPK10 TNF 9883899 558220 Here , we demonstrate that is *sufficient* to activate p42/p44 [MAPK] and p38 MAPK . Positive_regulation MAPK10 TNF 9930718 588834 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Positive_regulation MAPK10 TNF 9931102 588901 ( 100 U/mL ) transiently *activated* [MAPK] with a maximal induction 10 minutes after stimulation that returned to baseline levels by 2 hours after treatment . Positive_regulation MAPK10 TNF 9931102 588914 PD98059 also blocked *stimulated* [MAPK] activation in a concentration dependent manner , which is consistent with its inhibition of TNF-alpha directed migration . Positive_regulation MAPK10 TNF 9931102 588927 To identify which TNF-alpha receptor is involved in *induced* [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Positive_regulation MAPK10 TNF 9931102 588953 VSMC express both receptors , but induced [MAPK] *activation* was inhibited only by the TNF-R1 antibody . Positive_regulation MAPK10 TNF 9931102 588979 Both TRO and RSG inhibited migration , but neither attenuated *induced* [MAPK] activation , indicating that their antimigration activity was exerted downstream of MAPK . Positive_regulation MAPK10 TNFSF10 12969966 1185568 Among the intracellular pathways investigated , significantly *stimulated* the extracellular signal regulated kinase 1/2 ( ERK1/2 ) but not the [p38/mitogen activated protein kinase (MAPK)] or the c-Jun NH2-terminal kinase (JNK) pathway . Positive_regulation MAPK10 TNFSF10 20951126 2364948 Taken together , this study provided first evidence demonstrating that , TNF-a- , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK10 TNFSF10 21152872 2373390 Taken together , we show herein that the upstream molecule of the *induced* [MAPK] activation is MEKK , as opposed to ASK1 , via the mediation of its signal through JNK/p38 in a caspase-8 dependent manner . Positive_regulation MAPK11 ADRB2 11018034 752787 induced p38 [MAPK] *activation* is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes . Positive_regulation MAPK11 ADRB2 12509508 1038736 beta-Arrestin 1 is required for internalization and [mitogen activated protein (MAP) kinase] *activation* by the . Positive_regulation MAPK11 ADRB2 19047375 2023481 Hematopoietic protein tyrosine phosphatase mediates *induced* regulation of p38 [mitogen activated protein kinase] in B lymphocytes . Positive_regulation MAPK11 ADRB2 9038193 415362 In the present work , we report that stimulation of the A2A-adenosine receptor and of the *activates* [mitogen activated protein kinase] ( MAP kinase ) in human endothelial cells based on the following criteria : adenosine analogues and beta-adrenergic agonists cause an ( i ) increase in tyrosine phosphorylation of the p42 isoform and to a lesser extent of the p44 isoform of MAP kinase and ( ii ) stimulate the phosphorylation of myelin basic protein by MAP kinase; (iii) this is accompanied by a redistribution of the enzyme to the perinuclear region . Positive_regulation MAPK11 ADRB2 9363896 462905 We show that in HEK293 cells , *stimulation* of [mitogen activated protein (MAP) kinase] by the is mediated by the betagamma subunits of pertussis-toxin-sensitive G proteins through a pathway involving the non-receptor tyrosine kinase c-Src and the G protein Ras . Positive_regulation MAPK11 ALOX5 11807011 903505 In contrast , stress induced product formation and translocation of <5-LO> , as well as *activation* of p38 [MAPK] , occurred also after Ca ( ++ ) depletion . Positive_regulation MAPK11 ALOX5 21200133 2391682 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Positive_regulation MAPK11 ANGPT1 12039842 954278 Accordingly , ephrinB2 inhibited VEGF- and *induced* [Ras-MAPK] activities , whereas ephrinB2 did not alter VEGF induced Flk phosphorylation or Ang1 induced Tie2 phosphorylation . Positive_regulation MAPK11 ANGPT1 12213710 985637 Both VEGF and *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 [MAPK] . Positive_regulation MAPK11 ANGPT1 12213726 985707 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of and Ang-2 as well as the *activation* of [MAPK] , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation MAPK11 ANGPT1 16061664 1439066 *activated* [mitogen activated protein kinase (MAPK)] and phosphoinositide 3-kinase (PI3K) in IBE cells and HUVECs . Positive_regulation MAPK11 ANGPT1 16679392 1612150 Pretreatment with either DPI or apocynin also significantly attenuated *induced* Akt and p44/42 [MAPK] phosphorylation . Positive_regulation MAPK11 ANGPT1 16679392 1612166 Using mouse heart microvascular endothelial cells from wild-type ( WT ) mice and mice deficient in the p47(phox) component of NADPH oxidase ( p47 ( phox-/- ) ) , we found that although *stimulated* intracellular ROS , Akt and p42/44 [MAPK] phosphorylation , and cell migration in WT cells , the responses were strikingly suppressed in cells from the p47 ( phox-/- ) mice . Positive_regulation MAPK11 ANGPT1 20072135 2235284 *promoted* skin cell metabolism/viability , adhesion , and akt and [MAPK] ( p42/44 ) activations . Positive_regulation MAPK11 ANO1 22564524 2619159 *induces* [MAPK] and contributes directly to tumorigenesis and cancer progression . Positive_regulation MAPK11 CAPN8 21543591 2424075 Downstream , an Aß-mediated rise in p38 [mitogen activated protein kinase (MAPK)] activation was followed by downregulation of cAMP response element binding protein , and LTP impairment was *prevented* by inhibitors of p38 MAPK or . Positive_regulation MAPK11 CAPN8 24416390 2900943 Treatment with glutamate leads to early activation of NMDAR , which in turn leads to *mediated* cleavage of striatal enriched protein tyrosine phosphatase ( STEP ) and subsequent activation of p38 [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK11 CCL17 23711854 2792888 IL-33 induced the production of thymus and activation regulated and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 [MAPK] . Positive_regulation MAPK11 CCND1 11004713 735010 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping [ERK-MAPK] activation and c-Fos and *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation MAPK11 CCND1 12654183 1072981 [MAPK] may *induce* overexpression of protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation MAPK11 CCND1 15634644 1349551 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 [mitogen activated protein kinase] , and down-regulation of . Positive_regulation MAPK11 CCND1 16522728 1531455 We conclude that incretin induced beta-cell replication is dependent on cAMP/PKA , p42 [MAPK] and PI3K activities , which may *involve* transcriptional induction of . Positive_regulation MAPK11 CCND1 9537433 497554 Furthermore , in 25 of 26 cases of HCC which genomic DNA was available , 22 cases without genomic DNA amplification exhibited positive correlation , not only between protein expression of c-Fos and , but also between [MAPK/ERK] *activation* and cyclin D1 expression . Positive_regulation MAPK11 CD14 15625444 1349234 LPS interacts with the cell surface receptor , which generates transmembrane signals through Toll-like protein 4 *leading* to [mitogen activated protein kinase (MAPK)] p38 activation , cytokine synthesis , PMN beta2-integrin expression and oxidative burst . Positive_regulation MAPK11 CHI3L1 23755018 2797725 In addition , *induces* [FAK-MAPK] signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation MAPK11 CHI3L1 23972995 2836237 We also demonstrate that *activates* macrophage [mitogen activated protein kinase] , protein kinase B/AKT , and Wnt/ß-catenin signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation MAPK11 CLU 23051594 2702806 FOXL2 directly stimulates the Clu gene promoter , and we show that PTTG triggers ataxia telangiectasia mutated [kinase/IGF-I/p38MAPK] DNA damage/chromosomal instability signaling , which in turn also *induces* expression . Positive_regulation MAPK11 CTGF 11732999 885260 *induces* chondrocyte differentiation through a p38 [mitogen activated protein kinase] ( p38MAPK ) , and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase ( ERK ) . Positive_regulation MAPK11 CTGF 11732999 885274 In the proliferation phase , *induced* a approximately fivefold increase in the phosphorylation of p44/42 [MAPK/ERK] and a approximately twofold increase in that of p38 MAPK in an in vivo kinase assay . Positive_regulation MAPK11 CTGF 12218048 1012160 The inhibition of *induced* p42/44 [MAPK] or phosphatidylinositol 3-kinase (PI3K)/protein kinase B pathway activities abrogated the induction of fibronectin expression . Positive_regulation MAPK11 CTGF 16408113 1513475 *enhanced* the mRNA expression and protein release of fractalkine , MCP-1 , and RANTES , the expression of phospho ( P ) -p42/44 [mitogen activated protein kinase (MAPK)] , P-phosphoinositide 3-kinase (PI3-K) , P-Akt , and activity of nuclear factor-kappaB (NF-kappaB) in mesangial cells . Positive_regulation MAPK11 CTGF 16408113 1513499 P-p42/44 MAPK blockade inhibited the *induced* expression of P-p42/44 [MAPK] but not NF-kappaB , and partially decreased the levels of the above chemokines in supernatants . Positive_regulation MAPK11 CTGF 16522717 1531323 ( 3 ) *stimulated* dose dependent HSC adhesion and activity of p42/p44 [mitogen activated protein kinase] , the latter of which was antagonized by blocking the activity of focal adhesion kinase . Positive_regulation MAPK11 CTGF 16938382 1654122 No single module , but a mixture of the 4 modules provoked a significant activation of p38 [MAPK] in HCS-2/8 cells , which was *activated* by the full-length . Positive_regulation MAPK11 CTGF 19038999 2023079 Interestingly , CCN2-BMP-2 did not affect the *induced* phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Positive_regulation MAPK11 EDN2 12193071 980925 The molecular mechanisms of dependent *activation* of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Positive_regulation MAPK11 EDN2 12475899 1037763 *induced* a rapid phosphorylation of the [mitogen activated protein kinase (MAPK)/ERK] and increased collagen I gene activity in freshly isolated aortas . Positive_regulation MAPK11 EDN2 1280103 203030 rapidly *stimulates* [mitogen activated protein kinase] activity in rat mesangial cells . Positive_regulation MAPK11 EDN2 12855582 1149881 also *induced* the activation of p42/44 [mitogen activated protein kinase (MAPK)] in DCs . Positive_regulation MAPK11 EDN2 7509933 241597 *stimulates* [mitogen activated protein kinase] p42 activity through the phosphorylation of the kinase in rat mesangial cells . Positive_regulation MAPK11 EDN2 7849246 286721 *stimulates* [mitogen activated protein kinase] activity in mesangial cells through ETA . Positive_regulation MAPK11 EDN2 7943276 276388 has been shown to *activate* [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK11 EDN2 8836145 386162 In bovine airway smooth-muscle cells platelet derived growth factor ( PDGF ) and ( Et-1 ) *stimulate* sustained and comparable activation of [mitogen activated protein kinase] ( MAP kinase ) but display very different mitogenic efficacies , with PDGF inducing 50 times more DNA synthesis than Et-1 . Positive_regulation MAPK11 EFNB1 15502157 1347558 Further downstream of the signaling pathway , stimulation *led* to increased LAT ( linker for activation of T-cells ) phosphorylation and p44/42 and p38 [MAPK] activation . Positive_regulation MAPK11 EPHB2 10601128 574198 Tumor necrosis factor-alpha (TNF-alpha) alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only . Positive_regulation MAPK11 EPHB2 10872747 707023 Pre-treatment of the cells with PD98059 , a selective pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation MAPK11 EPHB2 11083274 750489 Tumor necrosis factor alpha , interleukin-1 (IL-1) , and IL-6 were the major inducers of , JNK , and p38 [MAPK] *activation* in cultured human synovial cells . Positive_regulation MAPK11 EPHB2 12386816 999761 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 [MAPK] and a biphasic *activation* of . Positive_regulation MAPK11 EPHB2 12403788 1036175 SB203580 , a p38 [MAPK] *inhibitor* , and PD98059 , an inhibitor , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation MAPK11 EPHB2 12486127 1056306 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain *had* little effect on basal Erk [MAPK] activation . Positive_regulation MAPK11 EPHB2 12511425 1070735 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation MAPK11 EPHB2 12801927 1120230 GE2 stimulation *induced* phosphorylation , whereas it did not alter the phosphorylation of c-Jun N-terminal kinase or p38 [MAPK] . Positive_regulation MAPK11 EPHB2 12832293 1105575 Exposure to E. coli DNA resulted in phosphorylation of ERK 1/2 [MAPK] and inhibitors of activity ( PD98059 , UO126 ) significantly *reduced* the evoked IL-8 production . Positive_regulation MAPK11 EPHB2 12878192 1115517 ( 2 ) the *activation* of JNK and p38 [MAPK] but not in embryonic fibroblasts ( MEFs ) derived from ASK1 knockout mice ( ASK1 ( -/- ) MEFs ) was depressed compared to MEFs derived from wild type mice ( ASK1 ( +/+ ) MEFs ) ; Positive_regulation MAPK11 EPHB2 14973553 1212558 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen activated protein kinase (MAPK)] signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation MAPK11 EPHB2 14998726 1216728 Furthermore , we found that PD98059 , an pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation MAPK11 EPHB2 15659876 1350303 The anabolic effect of TNF-alpha was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an . Positive_regulation MAPK11 EPHB2 16038626 1437407 SF significantly prevented Abeta induced increases in IL-1beta and p38 [MAPK] *activation* and also Abeta induced changes in and phospho-Akt/PKB expression levels . Positive_regulation MAPK11 EPHB2 17056059 1649525 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Positive_regulation MAPK11 EPHB2 17403539 1735932 Trauma-hemorrhage increased the production of IL-6 , IL-10 , IL-12 and TNF-alpha enhanced the expression of TLR4 , MyD88 as well as the *activation* of [MAPK] proteins ( p38 , and JNK ) in epidermal keratinocytes . Positive_regulation MAPK11 EPHB2 17416211 1777863 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK11 EPHB2 17464174 1731743 The mRNA and surface protein up-regulation of CCR1 and CCR2 in 9CRA stimulated cells were weakly blocked by the pretreatment of SB202190 , a p38 [MAPK] *inhibitor* , and PD98059 , an upstream inhibitor . Positive_regulation MAPK11 EPHB2 18164124 1869608 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 [MAPK] , but not by the *activation* of JNK , , and NF-kappaB pathway . Positive_regulation MAPK11 EPHB2 18266967 2000295 VEGF induced activation of p42 also *led* to the nuclear translocation of [MAPK/ERK1/2] . Positive_regulation MAPK11 EPHB2 18285354 1885404 Pre-treatment with the [MAPK] *inhibitors* SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( inhibitor ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation MAPK11 EPHB2 18338254 1938056 Interestingly , inhibition of by U0126 completely *prevented* artepillin C-induced p38 [MAPK] phosphorylation of PC12m3 cells . Positive_regulation MAPK11 EPHB2 18520049 1918671 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of , rather than by the *activation* of p38 [MAPK] , in the spinal cord . Positive_regulation MAPK11 EPHB2 18982426 2105745 These inhibitory effects were partially inhibited by SB203580 , a specific *inhibitor* of p38 [MAPK] , but not by PD98059 , a specific inhibitors of extracellular signal regulated kinase ( ) , and SP600125 , a specific inhibitor of c-Jun-N-terminal kinase (JNK) . Positive_regulation MAPK11 EPHB2 19189219 2113960 Moreover , EM1 treatment resulted in less activation of p38 [MAPK] and more *activation* of signaling in lipopolysaccharide stimulated DCs . Positive_regulation MAPK11 EPHB2 19276187 2051416 Treatment of cells with sphingosine induced suppression of and *activation* of p38 [MAPK] . Positive_regulation MAPK11 EPHB2 19429670 2106919 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either inhibitor , [p38MAPK] *inhibitor* or NF-kappaB inhibitor . Positive_regulation MAPK11 EPHB2 19522739 2103139 Treatment with [MAPK] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation MAPK11 EPHB2 19672126 2168063 A scratch wound assay of healing rates in SV40 immortalized human corneal epithelial cell line ( HCEC ) evaluated the relative contributions by p38 and and JNK [MAPK] signaling *activation* to wound healing . Positive_regulation MAPK11 EPHB2 20025124 2175511 Prior treatment of the cells with PD98059 , an kinase inhibitor or SB203580 , a [p38MAPK] *inhibitor* , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation MAPK11 EPHB2 20554538 2327620 The HNE enhanced Sp1 and NF-?B activities were attenuated by SB203580 , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , and PD98059 , an extracellular signal regulated kinase ( ) inhibitor , respectively . Positive_regulation MAPK11 EPHB2 21126656 2355797 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 [mitogen activated protein kinase] , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by . Positive_regulation MAPK11 EPHB2 21311676 2360032 Treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation MAPK11 EPHB2 21488184 2417971 Dexmedetomidine induced phosphorylation of JNK and p38 [MAPK] in rat aortic SMCs , but did not *induce* phosphorylation of . Positive_regulation MAPK11 EPHB2 21586573 2449664 Incubation of T cells with ESAT-6 induced phosphorylation and increased functional p38 [MAPK] activity , but not *activation* of or JNK . Positive_regulation MAPK11 EPHB2 21599960 2445722 In the present studies , induction of central sensitization as indicated by spinal dorsal horn [MAPK] *activation* , specifically and p38 phosphorylation , was assessed in the MIA-OA model . Positive_regulation MAPK11 EPHB2 23394443 2713232 When compared to hamsters bearing tumors that remained on the control diet , the buccal pouches of hamsters bearing tumors receiving turmeric showed the following results : ( 1 ) decreased cell proliferation ( diminished PCNA , cyclin D1 , and Bcl-2 ) and PCNA labelling index , ( 2 ) enhanced apoptosis ( increased Bax , caspase-3 , caspase-9 , and cytochrome c , and decreased survivin ) and apoptotic index , ( 3 ) decreased inflammation ( decreased Cox-2 ) , and ( 4 ) decreased [MAPK] *activation* ( and p-p38 ) . Positive_regulation MAPK11 EPHB2 23892041 2830333 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three [MAPK] *inhibitors* ( inhibitor PD98059 , JNK inhibitor SP600125 and p38 inhibitor SB203580 ) . Positive_regulation MAPK11 EPHB2 23914844 2840569 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 [MAPK] and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of , JNK , NF-?B . Positive_regulation MAPK11 EPHB2 23917355 2826019 Inhibition of Akt or activity *reduced* phosphorylation of STAT1 in Colon26L5-CUG2 cells whereas inhibition of p38 [MAPK] did not significantly decrease levels of STAT1 phosphorylation , indicating that cell proliferation signals may be involved in CUG2 mediated activation of STAT1 . Positive_regulation MAPK11 EPHB2 24225419 2897493 Therefore , by using the [MAPK] *inhibitors* SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific inhibitor ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation MAPK11 EPHB2 24297112 2894215 Following treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation MAPK11 EPHB2 9832563 551920 Cis-platinum , which activated [SAPK2] but *induced* little activity , also induced membrane blebbing that was dependent on the expression of HSP27 . Positive_regulation MAPK11 F2R 16052512 1460023 The p38 and ERK1/2 [MAPK] signaling cascades were also *activated* by stimulation , whereas the SAPK/JNK pathway was unaffected . Positive_regulation MAPK11 F2R 16467309 1548149 and PAR-2 stimulation rapidly *activated* both ERK1/2 and [p38MAPK] , and pharmacological blockade of MEK with either PD98059 or U0126 or of p38MAPK by SB203580 or SB202190 strongly inhibited thrombin- and SLIGKV induced COX-2 expression and 6-keto-PGF1alpha formation . Positive_regulation MAPK11 F2R 21252088 2402883 In the present study , we show that FVIIa , upon binding to EPCR on endothelial cells , activates endogenous protease activated receptor-1 (PAR1) and induces mediated p44/42 [mitogen activated protein kinase (MAPK)] *activation* . Positive_regulation MAPK11 F2R 24052258 2867014 However , the distinct non-canonical tethered ligands unmasked by neutrophil elastase and proteinase-3 , as well as synthetic peptides with sequences derived from these novel exposed tethered ligands , selectively stimulated mediated [mitogen activated protein kinase] *activation* . Positive_regulation MAPK11 F2R 8635212 357871 These results support the notion that the *activates* [MAPK] through PKC dependent pathways and that the incremental activation of MAPK by TRAP over that induced by thrombin is the consequence of enhanced activation through the PKC limb of the phosphoinositide lipid pathway . Positive_regulation MAPK11 FAS 14576831 1156603 A more physiological inhibitor , the intracellular PP2A inhibitor protein I2 ( PP2A ) , protected transfected HeLa cells in a similar way from mediated apoptosis and induced *activation* of [MAPK] in I2 ( PP2A ) transfected cells . Positive_regulation MAPK11 FAS 15280387 1302530 We further demonstrate that this pro-apoptotic effect of CO was independent of reactive oxygen species production and involved inhibition in induced *activation* of the pro-survival ERK [MAPK] . Positive_regulation MAPK11 FAS 16507991 1529631 Here we show that binding of Fas ligand to *activates* p38 [MAPK] in CD8+ T cells and that activation of this pathway is required for Fas mediated CD8+ T-cell death . Positive_regulation MAPK11 FAS 19417161 2179808 GST-MDA-7 killing was , in parallel , dependent on inactivation of extracellular signal regulated kinase 1/2 and on *induced* p38 [mitogen activated protein kinase] and c-jun NH ( 2 ) -terminal kinase-1/2 signaling . Positive_regulation MAPK11 FAS 21613257 2454274 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Positive_regulation MAPK11 FAS 21975294 2492841 Caspase-8 activity has an essential role in *mediated* [MAPK] activation . Positive_regulation MAPK11 FAS 8977313 403344 IFN-alpha2 did not alter the *induced* activity of [Mitogen activated protein kinase (MAPK)] 1 and did not inhibit the Apo-1/Fas mediated proteolytic cleavage of ADP-ribosyltransferase , a substrate of Interleukin-beta1 converting enzyme ( ICE ) and homologues . Positive_regulation MAPK11 FHL1 23456229 2781815 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Positive_regulation MAPK11 FOXA1 22879989 2641680 An increase in IGFBP-3 , mediated by depletion of , *inhibited* phosphorylation of [MAPK] and Akt , and increased expression of the cell cycle regulators p21 and p27 . Positive_regulation MAPK11 FUT4 20506505 2307953 These data suggested that not only *activates* [MAPK] and PI3K/Akt signals , but also promotes the crosstalk among these signaling pathways . Positive_regulation MAPK11 GLP1R 21356521 2394813 activation by Exendin-4 ( Ex-4 ) *increased* PKA and [MAPK] activity and decreased phosphorylation of AMPK in NTS . Positive_regulation MAPK11 GPR115 10958680 725237 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK11 GPR115 11916960 944989 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK11 GPR115 9182581 435183 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK11 GPR115 9826186 549580 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK11 GPR132 10958680 725226 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK11 GPR132 11474113 841736 Activation of by LPC *increased* intracellular calcium concentration , induced receptor internalization , activated ERK [mitogen activated protein kinase] , and modified migratory responses of Jurkat T lymphocytes . Positive_regulation MAPK11 GPR132 11916960 944978 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK11 GPR132 9182581 435172 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK11 GPR132 9826186 549569 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK11 GPR87 10958680 725306 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK11 GPR87 11916960 945058 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK11 GPR87 9182581 435252 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK11 GPR87 9826186 549649 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK11 HBEGF 10544013 563921 also rapidly *activated* [MAPK] and induced cyclin D1 in mid-G1 with kinetics similar to TGFalpha . Positive_regulation MAPK11 HBEGF 11171084 783792 Both p42 [MAPK] activation and mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation MAPK11 HBEGF 15380451 1298478 *induced* phosphorylation of ERK , p38 [MAPK] and Akt , which were suppressed by ZD1839 . Positive_regulation MAPK11 HBEGF 17928891 1858622 We report that cellular stress with methyl-beta-cyclodextrin ( MBCD ) , a molecule that extracts membrane cholesterol and thereby disrupts the structure of lipid rafts , strongly *induces* the synthesis of ( HB-EGF ) in keratinocytes through the activation of p38 [mitogen activated protein kinase] . Positive_regulation MAPK11 HBEGF 18990151 2028921 *Activation* of [Erk/MAPK] by was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation MAPK11 HBEGF 19048624 2023714 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked [MAPK] signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 MAPK , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Positive_regulation MAPK11 HBEGF 19559571 2110502 *induced* phosphorylation of p42/p44 [MAPK] in a few minutes . Positive_regulation MAPK11 HBEGF 20739666 2345887 Moreover , *induced* a stronger and more sustained activation of both the [mitogen activated protein kinase] and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation MAPK11 HBEGF 24188029 2921098 Here , we show that *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , [Mapk/Erk] pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation MAPK11 HRH1 11959800 931439 1. Previous studies have shown that the *activates* p42/p44 [mitogen activated protein kinases (MAPK)] in DDT ( 1 ) MF-2 smooth muscle cells via a phosphatidylinositol 3-kinase (PI-3K) dependent pathway . Positive_regulation MAPK11 HRH1 17965772 1820337 is *required* for TCR mediated p38 [MAPK] activation and optimal IFN-gamma production in mice . Positive_regulation MAPK11 HRH1 17965772 1820351 Moreover , signaling at the time of TCR ligation was *required* for activation of p38 [MAPK] , a known regulator of IFN-gamma expression . Positive_regulation MAPK11 IFI27 16953232 1682572 RET2A mediated regulation of p18 and , but not of cyclins D1 and D2 , *requires* functional [mitogen activated protein kinase] signaling . Positive_regulation MAPK11 IL1B 10640438 577500 and TNF alpha also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK11 IL1B 10704772 673003 CPI-1189 inhibits *induced* [p38-mitogen activated protein kinase] phosphorylation : an explanation for its neuroprotective properties ? Positive_regulation MAPK11 IL1B 10775561 686642 *activated* p44/42 [MAPK] , and this activation was enhanced in the presence of N-acetyl-L-cysteine . Positive_regulation MAPK11 IL1B 10864897 705722 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK11 IL1B 10864897 705774 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by TNF-alpha and . Positive_regulation MAPK11 IL1B 10864897 705796 TNF-alpha- and *induced* [ ( 3 ) H ] -thymidine incorporation and phosphorylation of p42/p44 [MAPK] was completely inhibited by PD98059 ( an inhibitor of MEK1/2 ) , indicating that activation of MEK1/2 was required for these responses . Positive_regulation MAPK11 IL1B 10969830 728484 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Positive_regulation MAPK11 IL1B 11032891 740452 *induces* p38 [MAPK] phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation MAPK11 IL1B 11037878 741239 also *stimulated* phosphorylation of p38 [MAPK] , SAPK/JNK , and ATF-2 . Positive_regulation MAPK11 IL1B 11126408 759771 TNFalpha and IFNgamma potentiate *induced* [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK11 IL1B 11126408 759784 [Mitogen activated protein kinase (MAPK)] activity that is *induced* by has been suggested to signal nitric oxide dependent as well as nitric oxide independent beta-cell destructive pathways . Positive_regulation MAPK11 IL1B 11126408 759797 The aim of this study was to investigate if TNFalpha and IFNgamma signal through mitogen activated protein kinases in isolated rat islets of Langerhans and if they potentiate [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK11 IL1B 11126408 759810 Further , TNFalpha and IFNgamma were found to synergistically increase [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK11 IL1B 11399523 824258 Glucose potentiates *induced* p38 [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK11 IL1B 11509550 848356 Although and TNF-alpha each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK11 IL1B 11557585 861401 *activated* the three [mitogen activated protein kinase] ( extracellular signal regulated kinases 1 and 2 , c-Jun NH2-terminal kinase/stress activated protein kinase , and p38 ) and the Janus kinase (JAK)-signal transducer and activator of transcription pathways . Positive_regulation MAPK11 IL1B 11698472 878050 *induced* phosphorylation and activation of p38 [MAPK] and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation MAPK11 IL1B 11698472 878096 *induced* phosphorylation of ERK and JNK as well as p38 [MAPK] in human endothelial cells . Positive_regulation MAPK11 IL1B 11728947 884807 We showed a dramatic decrease in *induced* phosphorylation of p38 [MAPK] , not extracellular signal regulated kinases 1/2 or jun NH2-terminal kinase , in rat cultured mesangial cells by FR167653 . Positive_regulation MAPK11 IL1B 11775830 766435 Role of protein tyrosine kinase in *induced* activation of [mitogen activated protein kinase] in fibroblast-like synoviocytes of rheumatoid arthritis . Positive_regulation MAPK11 IL1B 11853544 913369 Interestingly , *induced* p38 [MAPK] activity was greatly enhanced in ( alg+ ) compared with ( alg- ) cells . Positive_regulation MAPK11 IL1B 12117921 964663 mRNA expression by neutrophils was not dependent on p38 MAPK , and p38 [MAPK] was not *activated* in neutrophils incubated with A. phagocytophila . Positive_regulation MAPK11 IL1B 12131776 966855 and TNF-alpha *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK11 IL1B 12139924 969394 Regarding intracellular signaling , *activated* the p38 mitogen activated protein kinase (MAPK) but not the p42/p44 [MAPK] and , when combined with growth factors , intensified p38 activation but inhibited the growth-factor induced p42/p44 activation . Positive_regulation MAPK11 IL1B 12356282 993834 induced p44/42 [mitogen activated protein kinase (MAPK)] *activation* was inhibited by the MAPK/extracellular signal regulated protein kinase ( MEK ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK11 IL1B 12417253 1012951 Sphondin ( 50 microM ) did not affect the induced *activations* of p44/42 MAPK , p38 [MAPK] , and JNK . Positive_regulation MAPK11 IL1B 12500176 1026685 These data suggest that the presence of retinal holes and may *lead* to activation of HGF , [mitogen activated protein kinases (MAPK)] , c-jun and extracellular matrix remodeling , resulting in proliferative and migratory cells in the wounded retina . Positive_regulation MAPK11 IL1B 12507586 1038419 In this study we evaluated the role of epigallocatechin-3-gallate ( EGCG ) , a green tea polyphenol which mimics its anti-inflammatory effects , in modulating the induced *activation* of [MAPK] 's in human chondrocytes . Positive_regulation MAPK11 IL1B 12649265 1080065 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant MKK6 or p38beta2 MAPK inhibited induced p38 [MAPK] *activation* , COX-2 gene expression , and PGE2 release . Positive_regulation MAPK11 IL1B 12727980 1086555 P38 [MAPK] phosphorylation was *increased* by in nondecidualized ESC , whereas the IL-1 beta induced increase was suppressed in the decidualized cells . Positive_regulation MAPK11 IL1B 12727980 1086568 Treatment with 8-bromo-cAMP reduced *induced* phosphorylation of p38 [MAPK] in nondecidualized ESC . Positive_regulation MAPK11 IL1B 12727980 1086582 In contrast , treatment with H89 , a protein kinase A inhibitor , reversed a reduction in *induced* p38 [MAPK] phosphorylation in the decidualized cells . Positive_regulation MAPK11 IL1B 12727980 1086596 The altered property of decidualized cells is thought to be caused by attenuation of *induced* p38 [MAPK] phosphorylation in a way that involves the activation of the cAMP/protein kinase A pathway . Positive_regulation MAPK11 IL1B 12882449 1116287 NAC ( 1 mM ) also decreased the induced *activation* of p38 [MAPK] . Positive_regulation MAPK11 IL1B 12952251 1137415 Using Western-blot analysis , no effect of cAMP was found on the *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK11 IL1B 12952251 1137429 No decrease was observed in *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK11 IL1B 14563491 1154858 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Positive_regulation MAPK11 IL1B 15039421 1251231 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of , and RIP2 dependent *activation* of NF-kappaB and p38 [MAPK] mediated by the caspase recruitment domain . Positive_regulation MAPK11 IL1B 15048855 1225176 Therefore , , which contributes to stroke induced brain injury and *activates* [p38/SAPK2] , and hyperosmolarity induced by sorbitol , a potent stimulus of p38/SAPK2 in non-neuronal cells , were used to investigate a possible involvement of p38/SAPK2 in GJC modulation in mouse cultured astrocytes . Positive_regulation MAPK11 IL1B 15111866 1241237 We further demonstrated that p38 MAPK is activated by and PDGF with different kinetics and that p38 [MAPK] is *required* for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation MAPK11 IL1B 15208668 1281341 *induced* the activation of extracellular signal regulated kinases-1/2 and P38 [mitogen activated protein kinase (MAPK)] , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation MAPK11 IL1B 15341531 1291759 In accordance with these findings , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) , which was attenuated by U0126 , SB202190 , or SP600125 , respectively . Positive_regulation MAPK11 IL1B 15389584 1354317 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] and JNK which was attenuated by pretreatment with U0126 or SP600125 , respectively . Positive_regulation MAPK11 IL1B 15489374 1359421 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and JNK was attenuated by pretreatment with U0126 , SB-202190 , or SP-600125 , respectively . Positive_regulation MAPK11 IL1B 15755725 1403419 The inhibitory effect of on alpha ENaC expression was *mediated* by the activation of p38 [MAPK] in both rat and human ATII cells and was independent of the activation of alpha v beta6 integrin and transforming growth factor-beta . Positive_regulation MAPK11 IL1B 16033422 1436163 Intrathecal *leads* to a time dependent up-regulation of phosphorylated p38 ( p-p38 ) [MAPK] protein expression in the spinal cord 30-240 min following IL-1beta injection ( i.t. ) . Positive_regulation MAPK11 IL1B 16033422 1436177 However , pretreatment with a p38 MAPK inhibitor significantly reduced the *induced* p-p38 [MAPK] expression by 38-49 % , and nearly completely blocked the subsequent iNOS expression ( reduction by 86.6 % ) , NO production , and thermal hyperalgesia . Positive_regulation MAPK11 IL1B 16043966 1459739 Western blot analysis demonstrated that *increased* the activation of phosphorylated MEK and p38 [MAPK] in GH3 cells . Positive_regulation MAPK11 IL1B 16140882 1450803 *induced* phosphorylation of [p38-MAPK] , but not that of c-Jun-N-terminal kinase or extracellular regulated kinase , was most susceptible to inhibition by low doses of PFE , and the addition of PFE blocked the activity of p38-MAPK in a kinase activity assay . Positive_regulation MAPK11 IL1B 16141635 1454867 DHA stimulated both rapid and prolonged activation of p44/42 , but not p38 , [mitogen activated protein kinase (MAPK)] *induced* by and PMA . Positive_regulation MAPK11 IL1B 16153910 1455433 The kidney was analyzed for expression of tumor necrosis factor alpha , , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 [mitogen activated protein kinase] , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation MAPK11 IL1B 16452991 1611733 Western blots showed that and TNF-alpha *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK11 IL1B 16528573 1549426 The aim of this study was to investigate if Gadd45b prevents *induced* beta cell [MAPK] signalling and apoptosis . Positive_regulation MAPK11 IL1B 16645161 1604675 significantly *increased* the phosphorylation of p38 [MAPK] and cPLA(2) . Positive_regulation MAPK11 IL1B 16698013 1575652 JST ( 0.01-1 mg/ml ) also attenuated the expression of cyclooxygenase (COX)-2 and activation of p38 [MAPK] *induced* by and A beta ( 1-42 ) . Positive_regulation MAPK11 IL1B 16718462 1584907 A synthetic peptide , C3d , reported to bind NCAM , did not activate MAPK or Akt as reported in neurons but inhibited *induced* [MAPK] activity , thereby mimicking the effect of SU5402 . Positive_regulation MAPK11 IL1B 16718462 1584932 We suggest that NCAM signalling through FGFR is required for efficient IL-1beta pro-apoptotic signalling by facilitating induced [MAPK] *activation* downstream of the NF-kappaB-MAPK branching point . Positive_regulation MAPK11 IL1B 16718462 1584963 Further , these data identify a novel function of C3d as an inhibitor of NCAM induced FGFR activity and of *induced* [MAPK] activation in beta cells . Positive_regulation MAPK11 IL1B 16959849 1639696 *caused* an increase in the phosphorylation of ERK , but not [p38MAPK] or c-Jun N-terminal kinase . Positive_regulation MAPK11 IL1B 16964394 1611552 Inhibitors of p38 [MAPK] and/or JNK significantly suppressed VEGF secretion both in the *presence* and absence of , while inhibitors of COX-2 , ERK1/2 , and PI3-K did not . Positive_regulation MAPK11 IL1B 17208222 1695811 Thalidomide also suppressed *induced* p38 [mitogen activated protein kinase (MAPK)] activation , while a p38 MAPK inhibitor destabilized COX-2 mRNA and the cytoplasmic shuttling of HuR induced by IL-1beta . Positive_regulation MAPK11 IL1B 17311279 1719288 *stimulated* phosphorylation of p42/p44 MAPK , p38 [MAPK] , and JNK was attenuated by pretreatment with U0126 , SB202190 , SP600125 , or transfection with these dominant negative mutants of MEK , ERK , p38 and JNK , respectively . Positive_regulation MAPK11 IL1B 17390080 1716130 We have previously demonstrated that *induced* HBD-2 mRNA expression in A549 cells through activation of nuclear factor-kappaB (NF-kappaB) transcriptional factor as well as p38 [mitogen activated protein kinase (MAPK)] , c-Jun N-terminal kinase (JNK) , or phosphatidylinositol-3-kinase (PI3K) . Positive_regulation MAPK11 IL1B 17390080 1716160 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Positive_regulation MAPK11 IL1B 17390080 1716190 Triptolide inhibited *induced* [MAPK] phosphatase-1 expression at the transcriptional level and resulted in sustained phosphorylation of JNK or p38 MAPK , explaining the little effect of triptolide on IL-1beta induced phosphorylation of these kinases . Positive_regulation MAPK11 IL1B 17438131 1742770 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by TNF-alpha and , but not by ansiomycin or sorbitol . Positive_regulation MAPK11 IL1B 17559635 1753260 also *activated* extracellular signal regulated kinase , p38 [MAPK] , and c-Jun N-terminal kinase . Positive_regulation MAPK11 IL1B 17645739 1793268 Interestingly , Dex attenuated mediated *activation* of p38 [MAPK] and JNK , but not of AKT . Positive_regulation MAPK11 IL1B 17694686 1782103 IL-1beta induced NO levels and thermal hyperalgesia in rats , likely via either inhibiting the mediated p38 [MAPK] *activation* and subsequent iNOS induction , or direct attenuation of the central iNOS activity , which therefore reduces the central sensitization of inflammatory pain . Positive_regulation MAPK11 IL1B 17920534 1804188 SA981 at a concentration of 100 microM partially inhibited *induced* phosphorylation of [p38MAPK] and Akt ( 12.0 % and 36.1 % inhibition of each total amount of phosphoprotein under IL-1beta coexistence condition , respectively ) . Positive_regulation MAPK11 IL1B 17925024 1835152 *stimulated* phosphorylation of c-jun amino-terminal kinase , p38 [MAPK] and extracellular signal regulated kinase-1/2 . Positive_regulation MAPK11 IL1B 18026701 1827819 Moreover , glucosamine suppressed the *induced* phosphorylation of p38 [MAPK] ( p < 0.05 at > 0.1 mM ) and the IL-1beta binding to its receptors ( p < 0.05 at 1 mM ) . Positive_regulation MAPK11 IL1B 18065201 1853661 *stimulated* activation of ERK1/2 and p38alpha [MAPK] mediates the transcriptional up-regulation of IL-6 , IL-8 and GRO-alpha in HeLa cells . Positive_regulation MAPK11 IL1B 18348730 1925313 The *activation* or inhibition of p38 [MAPK] by and/or SB203580 was analyzed by western blotting . Positive_regulation MAPK11 IL1B 18348730 1925326 *activated* the phosphorylation of p38 [MAPK] and this effect was abolished by SB203580 . Positive_regulation MAPK11 IL1B 18427719 1920721 Phosphorylated p38 ( Phos-p38 ) [mitogen activated protein kinase] was *stimulated* in SW-1353 cells by but not by HA alone . Positive_regulation MAPK11 IL1B 18556347 1965927 or leptin individually *induced* threonine/tyrosine phosphorylation of p38 [MAPK] , whereas only leptin induced tyrosine phosphorylation of JAK2 , suggesting that leptin may enhance hBD-2 production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with NF-kappaB , which is activated by IL-1beta . Positive_regulation MAPK11 IL1B 18667841 1948050 Furthermore , induced p38 [mitogen activated protein kinase (MAPK)] *activation* and upregulation of VEGF-C mRNA and protein in LLC cells was also suppressed by artemisinin or by the p38 MAPK inhibitor SB-203580 , suggesting that p38 MAPK could serve as a mediator of proinflammatory cytokine induced VEGF-C expression . Positive_regulation MAPK11 IL1B 19362079 2081457 *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 [mitogen activated protein (MAP) kinase] , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation MAPK11 IL1B 19522843 2136337 In chondrocytes , CS diminishes *induced* increases in p38 [mitogen activated protein kinase] ( p38MAPK ) and signal regulated kinase 1/2 ( Erk1/2 ) phosphorylation , and decreases nuclear factor-kappaB (NF-kappaB) nuclear translocation and as a consequence , reduces the formation of pro-inflammatory cytokines , IL-1beta and TNF-alpha , and pro-inflammatory enzymes , such as phospholipase A2 (PLA2) , cyclooxygenase 2 (COX-2) and nitric oxide synthase-2 (NOS-2) . Positive_regulation MAPK11 IL1B 19765281 2163521 Treatment with PIP-18 blocked *induced* p38 [MAPK] phosphorylation and resulted in attenuation of sPLA2-IIA and MMP mRNA transcription in RA SF cells . Positive_regulation MAPK11 IL1B 20060906 2218519 In the present study , we demonstrate that *caused* activation of p38 [mitogen activated protein kinase] and that the p38 inhibitor SB203580 significantly blocked the effect of IL-1beta on I ( NMDA-OUT ) in hippocampal CA1 neurons . Positive_regulation MAPK11 IL1B 20353947 2266462 In model 1 , a differentiation model , CLA *activation* of [MAPK] and induction of interleukin-8 (IL-8) , IL-6 , , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation MAPK11 IL1B 21659536 2455192 Distinct roles for Nod2 protein and autocrine in muramyl dipeptide *induced* [mitogen activated protein kinase] activation and cytokine secretion in human macrophages . Positive_regulation MAPK11 IL1B 24692548 2935243 At 1 h , this was responsible for the dexamethasone inhibition of induced [MAPK] *activation* and CXCL1 and CXCL2 mRNA expression , with a similar trend for CSF2 . Positive_regulation MAPK11 IL1B 9475519 486789 Of these , *activated* only [MAPK] . Positive_regulation MAPK11 IL1B 9475519 486802 In cultured rat astrocytes , *caused* activation of [MAPK] without inducing proliferation . Positive_regulation MAPK11 IL1B 9575890 502729 Our data also indicate that both insulin and IGF-I enhance *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation and SAPK activation . Positive_regulation MAPK11 IL1B 9582321 503934 Previously we reported that *induces* activation of JNK/SAPK and p38 [MAPK] with concomitant up-regulation of cyclooxygenase (Cox)-2 expression and prostaglandin E2 ( PGE2 ) synthesis . Positive_regulation MAPK11 IL1B 9614146 509327 By Western blotting with phosphospecific antibodies and by immunocomplex kinase assay , was shown to *activate* extracellular signal regulated kinase ( ERK ) 1/2 and p38 [mitogen activated protein kinase] ( p38 ) in islets and rat insulinoma cells . Positive_regulation MAPK11 IL1B 9786861 540912 We reported previously that rapidly *activates* the c-Jun NH2-terminal/stress activated protein kinases ( JNK/SAPK ) and p38 [mitogen activated protein kinase (MAPK)] and also induces Cox-2 expression and prostaglandin E2 ( PGE2 ) production . Positive_regulation MAPK11 IL1B 9786861 540958 Overexpression of the kinase-dead form of MKK3 or MKK6 demonstrated that either of these two mutant kinases inhibited *induced* p38 [MAPK] phosphorylation and Cox-2 expression but not JNK/SAPK phosphorylation and activation . Positive_regulation MAPK11 ITGB2 12600815 1099056 IL-3 , IL-5 , and GM-CSF could enhance p38 [MAPK] and NF-kappaB activity and *induce* ICAM-1 , CD11b , and expressions on eosinophils . Positive_regulation MAPK11 ITGB2 19843511 2203199 Furthermore , beta2 integrins modulated the capacity of isolated peritoneal macrophages to take up acetylated LDL and native LDL and to phagocytose apoptotic cells , possibly via *dependent* [mitogen activated protein kinase] signalling . Positive_regulation MAPK11 LBP 20615568 2309931 Despite activating NFkappaB , NOD1 ligand did not upregulate hepatocyte production of the acute phase proteins lipopolysaccharide binding protein , serum amyloid A , or soluble CD14 in cell culture supernatants , or upregulate mRNA expression of , serum amyloid A , C-reactive protein , or serum amyloid P . NOD2 ligand ( MDP ) did not *activate* hepatocytes when given alone , but did synergize with Toll-like receptor ligands , lipopolysaccharide (LPS) , and polyI : C to activate NFkappaB and [MAPK] . Positive_regulation MAPK11 MAP2K6 10050043 592926 In one set of experiments , we *inhibited* the activation of [MAPK] by pretreating cells with PD098059 , a specific inhibitor of ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAPK11 MAP2K6 10079106 595476 Although MKK3 , MKK4 , and all *activated* p38 [MAPk] in experimental models , only MKK3 was found to activate recombinant p38 MAPk in LPS treated neutrophils . Positive_regulation MAPK11 MAP2K6 10471331 641604 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Positive_regulation MAPK11 MAP2K6 10601295 574411 In addition , *activation* of p38 [MAPK] by constitutively active or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAPK11 MAP2K6 10713051 674372 Conversely , the inhibitors PD98059 and UO126 could *attenuate* EGF induced [mitogen activated protein kinase] activation , they do not affect the EGF induced mobility shift of caveolin-1 . Positive_regulation MAPK11 MAP2K6 10759527 683145 These results demonstrate that a plant can phosphorylate and *activate* [MAPK] , and that Tyr phosphorylation is critical for the catalytic activity of MAPK in plants . Positive_regulation MAPK11 MAP2K6 10816593 714745 The MAPK kinase selectively *stimulates* p38 [MAPK] and confers protection against stress induced apoptosis in cardiac myocytes . Positive_regulation MAPK11 MAP2K6 10891559 711189 MAP kinases (MAPK) in both G-1 and G-5 cells were indistinguishably phosphorylated , yet *dependent* [MAPK] activation was observed only in G-5 cells . Positive_regulation MAPK11 MAP2K6 11005808 752416 A inhibitor , PD98059 , *inhibited* heat shock ERK [MAPK] activation by > 75 % . Positive_regulation MAPK11 MAP2K6 11085935 750724 Similarly , *activation* of JNK by Ad-MKK7D and [p38-MAPK] by resulted in the increased expression of PGHS-2 . Positive_regulation MAPK11 MAP2K6 11237743 790301 The MAPK kinase ( ) inhibitor , PD98059 , *blocked* GSA stimulated [MAPK] activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Positive_regulation MAPK11 MAP2K6 11304531 826827 The *activation* of p38 [MAPK] by Galpha ( q ) and Gbetagamma was blocked by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Positive_regulation MAPK11 MAP2K6 11787422 891923 Indeed the MAPK kinase ( = ) inhibitor PD98059 *inhibits* the activation of parasite [MAPK] , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Positive_regulation MAPK11 MAP2K6 11822870 909051 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of [MAPK] pathway *inhibitors* ( inhibitors PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAPK11 MAP2K6 12009309 940809 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Positive_regulation MAPK11 MAP2K6 12203369 983215 Furthermore , PKC inhibitors or an inhibitor completely *suppressed* both TPA induced activation of [MAPK] and promotion of anchorage independent growth , but a cPKC-selective inhibitor partially suppressed TPA induced promotion of the growth . Positive_regulation MAPK11 MAP2K6 12356282 993840 IL-1beta induced p44/42 [mitogen activated protein kinase (MAPK)] activation was *inhibited* by the MAPK/extracellular signal regulated protein kinase ( ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK11 MAP2K6 12377770 1019984 These results suggest that MKK3 , rather than , *mediates* alphav integrin induced p38 [MAPK] activation . Positive_regulation MAPK11 MAP2K6 12450322 1018633 ANG II significantly increased aldosterone release , and this effect was inhibited by the LO inhibitor baicalein , as well as a specific p38 [MAPK] *inhibitor* , SB202190 , but not by PD098059 , a specific inhibitor of the ERK activator . Positive_regulation MAPK11 MAP2K6 12637559 1085466 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Positive_regulation MAPK11 MAP2K6 12659851 1073505 MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a ( MAP2K ) , which in turn *activates* a [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK11 MAP2K6 12845643 1108585 Finally , both ODQ and UO126 blocked the capacity of L-arginine to restore ERK ( 1/2 ) phosphorylation in L-NAME treated cells , demonstrating that GC and are both *required* for endogenous NO-mediated [MAPK] activation . Positive_regulation MAPK11 MAP2K6 15104236 1240299 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( ) inhibitor , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAPK11 MAP2K6 15172888 1288376 Importantly , the presence of inhibitors only at the time of the transport assay markedly *impaired* both insulin stimulated glucose uptake and [MAPK] signaling . Positive_regulation MAPK11 MAP2K6 15172888 1288476 Conversely , removal of inhibitors before the transport assay *restored* glucose uptake and [MAPK] signaling . Positive_regulation MAPK11 MAP2K6 15304546 1322503 Furthermore , *activation* of [ERK/MAPK] by the coexpression of constitutively active predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAPK11 MAP2K6 15365248 1294561 Treatment of keratinocytes with PD98059 , inhibitor , and SB20358 , p38 [MAPK] *inhibitor* , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAPK11 MAP2K6 15570612 1355557 Although the inhibitors *suppressed* [MAPK] phosphorylation in both OA- and AICAR treated oocytes , meiotic resumption was not causally linked to MAPK phosphorylation in either group . Positive_regulation MAPK11 MAP2K6 15867183 1404241 In cultured cardiac myocytes , specific *activation* of stress activated [mitogen activated protein kinase] , p38 , by upstream activator led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAPK11 MAP2K6 15879307 1411356 Conversely , constitutively active *induced* p38 [MAPK] activation that recapitulated the effects of polyphenols by inducing ERalpha phosphorylation and downstream activation of Akt , and eNOS . Positive_regulation MAPK11 MAP2K6 16157033 1455753 SB203580 , a [P38MAPK] *inhibitor* , and U0126 , a inhibitor , both completely blocked ADM mediated responses in MsC . Positive_regulation MAPK11 MAP2K6 17416211 1777869 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK11 MAP2K6 18401006 1925816 CyaA enhanced LPS induced phosphorylation of p38 [MAPK] and ERK in DC , and inhibitors of p38 MAPK , , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation MAPK11 MAP2K6 18754769 1968429 ( MKK) 3 and 6 are the main p38 [mitogen activated protein kinase] *activators* in mammals . Positive_regulation MAPK11 MAP2K6 18771907 1962674 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a inhibitor , and SB203580 , an *inhibitor* of p38 [mitogen activated protein (MAP) kinase] , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAPK11 MAP2K6 21892182 2491661 Further , we show that *activation* of p38 [MAPK] by expression of constitutively active ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAPK11 MAP2K6 22164285 2517909 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of and marked *activation* of p38 [MAPK] . Positive_regulation MAPK11 MAP2K6 22785235 2691887 TRH induced CRE promoter was inhibited by [mitogen activated protein kinase/ERK] kinase ( MEK ) inhibitor and was *increased* by overexpression of . Positive_regulation MAPK11 MAP2K6 7644477 318658 Inhibition of by PD 098059 *prevented* activation of [MAPK] and subsequent phosphorylation of MAPK substrates both in vitro and in intact cells . Positive_regulation MAPK11 MAP2K6 7822248 285591 ( MKK ) phosphorylates and *activates* [mitogen activated protein kinase (MAPK)] in response to stimulation of various eukaryotic signaling pathways . Positive_regulation MAPK11 MAP2K6 7889302 289435 2. Both nucleotides stimulate phosphorylation and *activation* of [mitogen activated protein kinase] and a biphasic phosphorylation of the up-stream . Positive_regulation MAPK11 MAP2K6 8180183 256235 This stimulation of the activator was temporally *followed* by increased activities of MEK and [MAPK] . Positive_regulation MAPK11 MAP2K6 8226933 235406 *Activation* of extracellular signal regulated kinase ( ERK ) or [mitogen activated protein kinase] by ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAPK11 MAP2K6 8394352 228236 We show that a similar activity phosphorylates and *activates* [MAPK] in both growth factor stimulated ( epidermal growth factor and thrombin ) and oncogene ( gip2 , v-src , and v-raf ) -transfected cells . Positive_regulation MAPK11 MAP2K6 8550616 346662 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Positive_regulation MAPK11 MAP2K6 8663100 368153 The [MAPK] and NHE activities induced by PMA were *inhibited* by staurosporine , a potent inhibitor for protein kinase C ( PKC ) , and by MAPK kinase ( ) inhibitor , PD98059 , but were not affected by the tyrosine kinase inhibitor genistein . Positive_regulation MAPK11 MAP2K6 8663100 368247 In contrast , both AVP induced [MAPK] and NHE activities were *inhibited* by genistein and inhibitor but were not affected by staurosporine . Positive_regulation MAPK11 MAP2K6 8816498 384290 *activates* [mitogen activated protein kinase (MAPK)] , which phosphorylates other kinases as well as transcription factors . Positive_regulation MAPK11 MAP2K6 9029150 413631 SAPK3 and [SAPK2] were *activated* at similar rates in vitro by ( also termed MKK6 ) , and SAPKK3 was the only activator of SAPK3 that was induced when KB or 293 cells were exposed to cellular stresses or stimulated with IL-1 or TNF . Positive_regulation MAPK11 MAP2K6 9135064 427607 In addition to *dependent* [MAPK] activation , we provide evidence for MEK independent regulation of the MAPKs . Positive_regulation MAPK11 MAP2K6 9166761 432455 The first step in [MAPK] *activation* by must be the formation of a MEK x MAPK enzyme-substrate complex , followed by phosphorylation producing monophosphorylated MAPK ( pMAPK ) . Positive_regulation MAPK11 MAP2K6 9626658 511883 These results indicate that *mediates* the IGF-I/insulin induced p42/ p44 [MAPK] activation . Positive_regulation MAPK11 MAP2K6 9864179 582724 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of ERK , but not p38 [MAPK] , induced by G-CSF , GM-CSF , or TNF . Positive_regulation MAPK11 MMP7 16848631 1588317 and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 [mitogen activated protein kinase] activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MAPK11 MMP7 21999204 2547383 Mesothelin enhances invasion of ovarian cancer by *inducing* through [MAPK/ERK] and JNK pathways . Positive_regulation MAPK11 MUC16 11481474 843834 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a [mitogen activated protein kinase] ( Erk 1/2 ) , and *activation* of transcription . Positive_regulation MAPK11 PECAM1 18029285 1866920 In contrast , expression of Delta15 in PECAM-1-/- bEND cells *had* minimal effects on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Positive_regulation MAPK11 PGC 22105890 2599540 Our studies also revealed that overexpression of in cardiomyocytes *inhibited* basal and T3-induced p38 [MAPK] phosphorylation . Positive_regulation MAPK11 PIGR 20450283 2257146 Induction of expression in HT-29 cells *required* NF-kappaB signaling but not [MAPK] signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation MAPK11 PLAT 19436314 2107037 cerebrospinal fluid and brain parenchymal ERK [MAPK] was elevated by H/I and this upregulation was *potentiated* by , but blunted by RBC-tPA . Positive_regulation MAPK11 PLAT 21037505 2499493 Red blood blocked c-Jun-N-terminal kinase but *potentiated* p38 [mitogen activated protein kinase] upregulation after photothrombotic injury . Positive_regulation MAPK11 PLAU 10766865 684603 surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha [mitogen activated protein kinase] activity . Positive_regulation MAPK11 PLAU 15031204 1257167 In HeLa cells the dominant negative form of JNK interferes with the p42/p44 [MAPK] *activation* of the . Positive_regulation MAPK11 PLAU 15874933 1405696 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 [MAPK] , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Positive_regulation MAPK11 PLAU 15874933 1405729 Although *induced* phosphorylation of both ERK1/2 and p38 [MAPK] was blocked by Galphai inhibition , inhibition of PI3K and Ras decreased the uPA induced phosphorylation of ERK1/2 but not p38 MAPK . Positive_regulation MAPK11 PLAU 18656457 1960562 Exogenous administered at 4 h post H/I further *stimulated* ERK [MAPK] phosphorylation , which was blocked by RAP . Positive_regulation MAPK11 PLAU 9660790 517497 The receptor *mediates* tyrosine phosphorylation of focal adhesion proteins and activation of [mitogen activated protein kinase] in cultured endothelial cells . Positive_regulation MAPK11 PLAU 9660790 517510 The induced *activation* of [MAPK] was completely inhibited by genistein , but not by 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo [ 3 , 4-d ] pyrimidine , a specific inhibitor of Src family kinases . Positive_regulation MAPK11 PODXL 17616675 1769271 expression also *led* to an increase in [mitogen activated protein kinase (MAPK)] and phosphatidylinositol 3-kinase (PI3K) activity . Positive_regulation MAPK11 PODXL 17616675 1769318 These findings suggest that leads to increased in vitro migration and invasion , increased MMP expression , and *increased* activation of [MAPK] and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MAPK11 PTGER2 19233324 2072057 Further , PGE ( 2 ) , EP2A and EP4A did not increase BMP2/4 mRNA levels in RC cells , and *induced* phosphorylation of p38 [MAPK] was not eliminated by Noggin . Positive_regulation MAPK11 SLC38A3 15331357 1288007 In contrast , *stimulated* [MAPK] activation was blocked by > 80 % by dominant negative Ras but not by dominant negative Rho and Cdc42 . Positive_regulation MAPK11 SNCAIP 12639553 1068701 In addition , [MAPK] was *activated* by through Edg-1 , Sph-1-P receptor . Positive_regulation MAPK11 SPHK1 18602364 1941500 As a result , inhibition of by SKI *blocked* phosphorylation of p38 [MAPK] , showing that SPHK activation by IL-18 is an upstream signal of p38 MAPK activation . Positive_regulation MAPK11 STK39 17237610 1690241 The phosphorylation of cytoplasmic p38 [MAPK] in Akata cells was *reduced* by the inhibitor , 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperazine ( H7 ) . Positive_regulation MAPK11 TLR7 16424221 1515545 MKP-1-deficient macrophages also show enhanced constitutive and *induced* activation of p38 [MAPK] . Positive_regulation MAPK11 TLR7 23979601 2850625 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Positive_regulation MAPK11 TLR7 24879442 2940976 GIT2 terminates *induced* NF-?B and [MAPK] signaling by recruiting the deubiquitinating enzyme Cylindromatosis to inhibit the ubiquitination of TRAF6 . Positive_regulation MAPK11 TNF 10504489 648980 Pretreatment with SB203580 ( 10 microM ) had no effect on basal or TNF-alpha stimulated phosphorylation of p38 MAPK but completely abolished *stimulated* p38 [MAPK] activity . Positive_regulation MAPK11 TNF 10521481 653110 The study presented here shows that autoregulation of gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 [mitogen activated protein (MAP) kinase] activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation MAPK11 TNF 10570180 568158 Furthermore , LPS , UV irradiation , and *caused* activation of p38 [MAPK] whereas IFN-gamma did not . Positive_regulation MAPK11 TNF 10601128 574197 alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation MAPK11 TNF 10640438 577499 IL-1 beta and also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK11 TNF 10669634 665805 In this study , we show that *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation MAPK11 TNF 10753884 682340 Moreover , *stimulated* both the NF-kappaB and [mitogen activated protein (MAP) kinase] ( extracellular signal regulated kinase , c-Jun NH ( 2 ) -terminal kinase , and p38 MAP kinase ) signaling pathways in astrocytes . Positive_regulation MAPK11 TNF 10783388 707847 *dependent* p38 [MAPK] activation was detected in both Mo7e and Hut-78 cells and was blocked by the p38 MAPK inhibitor , SB203580 . Positive_regulation MAPK11 TNF 10783388 707900 SB203580 did not affect TNF-alpha signaled nuclear translocation and DNA binding activity of NF-kappaB , and inhibition of NF-kappaB function did not affect induced p38 [MAPK] *activation* , indicating that these events are not dependent on each other . Positive_regulation MAPK11 TNF 10864897 705721 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK11 TNF 10864897 705773 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by and IL-1beta . Positive_regulation MAPK11 TNF 11095634 755297 rapidly *activated* [MAPK] and increased the extent of attachment , spreading and migration on fibronectin and collagen type I ( P < 0.01 ) but not on collagen type IV . Positive_regulation MAPK11 TNF 11108246 756726 *activates* extracellular regulated kinase-1/2 ( ERK1/2 ) and [p38MAPK] . Positive_regulation MAPK11 TNF 11108836 757037 In RAW264 cells which differentiate into osteoclast-like multinucleated cells by TNF treatment alone , activation of p38 [mitogen activated protein (MAP) kinase] *induced* by murine was comparable to and independent of the receptor activator of necrosis factor-kappaB ligand . Positive_regulation MAPK11 TNF 11156586 780613 1. We have previously shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce interleukin-8 (IL-8) by human pulmonary vascular endothelial cells . Positive_regulation MAPK11 TNF 11167962 783064 It has previously been shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce cytokine , including RANTES , that N-acetylcysteine (NAC) attenuates cytokine production by human bronchial epithelial cells ( BECs ) , and that sensitivity to TNFalpha is inversely correlated with cellular redox state . Positive_regulation MAPK11 TNF 11266661 797167 However , *caused* no activation of p42/p44 [MAPK] or cytosolic phospholipase A(2) activity . Positive_regulation MAPK11 TNF 11277995 798109 *activates* extracellular regulated kinases ( ERKs ) and p38 [mitogen activated protein kinase] ( p38MAPK ) , and inhibits the expression of uncoupling protein-1 (UCP-1) and adipocyte-specific genes in rat fetal brown adipocytes . Positive_regulation MAPK11 TNF 11319753 806837 SB 203580 , a selective inhibitor of p38 MAPK , inhibited IL-1 and *induced* p38 [MAPK] activity and IL-6 production ( IC ( 50 ) s 0.3 -- 0.5 microM ) in osteoblasts and chondrocytes . Positive_regulation MAPK11 TNF 11319753 806856 In addition , IL-1 and also *activated* p38 [MAPK] in fetal rat long bones and p38 MAPK inhibitors inhibited IL-1- and TNF stimulated bone resorption in vitro in a dose dependent manner ( IC ( 50 ) s 0.3 -- 1 microM ) . Positive_regulation MAPK11 TNF 11435466 832527 However , the cytotoxic responses to daunorubicin and exogenous ceramide remain unaltered , as do the *induced* p42/p44 [MAPK] activation and CD54 expression . Positive_regulation MAPK11 TNF 11438547 843392 *activated* p38 [MAPK] and p44/p42 MAPK in wild-type but not in p60 ( -/- ) , p80 ( -/- ) , or p60 ( -/- ) p80 ( -/- ) macrophages . Positive_regulation MAPK11 TNF 11494147 846171 In this study we demonstrate that *triggers* only modest proliferation , as well as p44/p42 [mitogen activated protein kinase (MAPK)] and NF-kappaB activation , in MM.1S multiple myeloma ( MM ) cells . Positive_regulation MAPK11 TNF 11495721 846388 Furthermore , overexpression of dominant negative mutants , H-Ras-15A and Raf-N4 , significantly suppressed p42/p44 [mitogen activated protein kinase (MAPK)] activation *induced* by and PDGF-BB and attenuated the effect of TNF-alpha on BK-induced IP response , indicating that Ras and Raf may be required for activation of these kinases . Positive_regulation MAPK11 TNF 11509550 848354 Although IL-1 beta and each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK11 TNF 11592111 869657 Lipopolysaccharide (LPS) treatment of a microglial cell line ( N9 ) *induced* a time dependent activation of both p38 [mitogen activated protein kinase] ( p38 MAPK ) and nuclear factor-kappaB (NFkappaB) , with consequent increases in interleukin-1alpha (IL-1alpha) , , and nitric oxide ( NO ) production . Positive_regulation MAPK11 TNF 11694522 896412 *activated* the three mammalian [MAPK] , p44/42 , JNK , and p38 , in a distinct time- and concentration dependent manner . Positive_regulation MAPK11 TNF 11694522 896438 In conclusion , although *activates* all three known [MAPK] in human preadipocytes , only p44/42 and JNK appear to be involved in the regulation of lipolysis . Positive_regulation MAPK11 TNF 11750919 898170 Biochemical and immunocytochemical analysis showed that *activated* p38 mitogen activated protein kinase ( p38MAPK ) and c-Jun N-terminal kinase (JNK) but not p42/p44 [MAPK] . Positive_regulation MAPK11 TNF 11820362 908737 *activated* p38 [MAPK] and stimulated IL-6 secretion by MG-63 cells , and pre-incubation of cells with the p38 MAPK inhibitor abrogated TNF-alpha dependent IL-6 secretion . Positive_regulation MAPK11 TNF 11820362 908766 Transfection of IL-6 full-length and 5-deletion gene promoter reporter constructs indicated that p38 [MAPK] *activation* by enhanced IL-6 gene expression , and that the p38 MAPK-responsive region resided in the proximal 260-bp segment . Positive_regulation MAPK11 TNF 11820362 908802 In conclusion , although p38 [MAPK] *activation* by stimulates IL-6 secretion by MG-63 cells , it has opposing effects on c/EBPbeta and NFkappaB activity . Positive_regulation MAPK11 TNF 11930247 927417 The p44/42 [MAPK] activity was significantly *enhanced* by and the TNF-alpha effect was opposed by rhIL-10 . Positive_regulation MAPK11 TNF 11930247 927430 It is suggested that rhIL-10 can inhibit *induced* VSMC proliferation and phosphorylation of p44/42 [MAPK] . Positive_regulation MAPK11 TNF 12095140 960563 significantly increased permeability and *induced* p38 and ERK [MAPK] activation compared with controls ( P < 0.05 ) . Positive_regulation MAPK11 TNF 12114204 963993 *increased* the phosphorylation of p38 [MAPK] within 15 min. Anisomycin , an activator of p38 MAPK , increased p38 MAPK phosphorylation and decreased SP-A mRNA levels in a dose dependent manner . Positive_regulation MAPK11 TNF 12130576 966576 Phosphorylation of p38 [MAPK] was *induced* by RANKL , IL-1 , , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation MAPK11 TNF 12131776 966854 IL-1 beta and *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK11 TNF 12297009 991036 In this study , we examined the anti-apoptotic role of p38 [MAPK] that is *activated* by in neuronal PC12 cells . Positive_regulation MAPK11 TNF 12297009 991049 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Positive_regulation MAPK11 TNF 12393915 1025431 This model probiotic also inhibits *activation* of the pro-apoptotic [p38/mitogen activated protein kinase] by , interleukin-1alpha , or gamma-interferon . Positive_regulation MAPK11 TNF 12511413 1079031 The treatment of RAW264 cells with TSA and NaB inhibited induced nuclear translocation of NF-kappa B and sRANKL induced *activation* of p38 [mitogen activated protein kinase (MAPK)] signals . Positive_regulation MAPK11 TNF 12631113 1067614 Additional experiments examining the role of cAMP on MC fractalkine expression showed that the incubation of MCs with TNF-alpha and either db-cAMP or forskolin attenuated TNF-alpha stimulated fractalkine mRNA and protein expression , preceded by attenuation of *activated* phosphorylation of p42/44 [MAPK] , and c-Jun , but not phosphorylation of PKCzeta/iota or nuclear translocation of NF-kappaB . Positive_regulation MAPK11 TNF 12637577 1099302 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and *requires* p38 [MAPK] activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation MAPK11 TNF 12665666 1030369 This study was undertaken to examine the relationship between *induced* cardiomyocyte apoptosis and activation of p38 [mitogen activated protein kinase (MAPK)] through oxidative stress . Positive_regulation MAPK11 TNF 12665666 1030382 Corresponding to the apoptotic effect , at 10 ng/mL *caused* rapid phosphorylation of p38 [MAPK] in wild-type cardiomyocytes . Positive_regulation MAPK11 TNF 12694807 1080908 *induced* the phosphorylation of p44/p42 [mitogen activated protein (MAP) kinase] and p38 MAP kinase . Positive_regulation MAPK11 TNF 12731668 1086844 On the other hand , GM-CSF- or *induced* phosphorylation of ERK and p38 [MAPK] was unaffected by these inhibitors at the concentrations effective for the inhibition of O2- release and adherence . Positive_regulation MAPK11 TNF 12829618 1113803 However , *induced* [p38-MAPK] phosphorylation was markedly diminished in mkk3-/- vs mkk3+/+ hearts ( percent basal , 127+/-23 versus 540+/-267 , respectively , P=0.04 ) , suggesting an MKK independent activation mechanism by ischemia . Positive_regulation MAPK11 TNF 12844496 1149727 Rho inhibition decreases *induced* endothelial [MAPK] activation and monolayer permeability . Positive_regulation MAPK11 TNF 12844496 1149740 Because GTP binding proteins have been implicated in MAPK activation , we now hypothesize that the GTP binding protein Rho is a mediator of induced [MAPK] *activation* and increased endothelial permeability . Positive_regulation MAPK11 TNF 12844496 1149754 C3 transferase attenuated induced [MAPK] *activation* and blocked TNF induced endothelial permeability . Positive_regulation MAPK11 TNF 12867430 1141980 Subsequently , mediated p38 [MAPK] *activation* induced sialidase activity and CD44-HA binding . Positive_regulation MAPK11 TNF 12867430 1142104 Taken together , our results suggest that *induced* p38 [MAPK] activation may regulate the induction of functionally active HA-binding form of CD44 by activating sialidase in LPS stimulated human monocytic cells . Positive_regulation MAPK11 TNF 12881424 1116129 Importantly , does not *induce* ROS accumulation or prolonged [MAPK] activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death Positive_regulation MAPK11 TNF 12893778 1121027 We show that MKK3 and MKK6are essential for *stimulated* p38 [MAPK] activation . Positive_regulation MAPK11 TNF 12960255 1158285 To investigate a potential interplay between induced *activation* of p38 [MAPK] and NF-kappaB , the p38 MAPK inhibitor SB203580 and a dominant negative p38 MAPK mutant were used . Positive_regulation MAPK11 TNF 14516792 1147201 [MAPK] pathway *activation* via was confirmed by marked AP-1 activation detected in EMSA . Positive_regulation MAPK11 TNF 14561851 1165103 In cultured human umbilical vein endothelial cells ( HUVECs ) , and lipopolysaccharide *increased* phosphorylation of p38 [MAPK] ( P-p38 MAPK ) and increased ICAM-1 expression . Positive_regulation MAPK11 TNF 14592823 1209462 Analyzing the individual contribution of PF-4 and its costimuli in the control of these functions at the signaling level , we demonstrate that induced *activation* of p38 [mitogen activated protein (MAP) kinase] ( but not extracellular regulated kinase [ Erk ] kinases ) acts as general and essential costimulatory signal in PF-4 dependent neutrophil exocytosis . Positive_regulation MAPK11 TNF 14632659 1170648 *activated* p38 [MAPK] in DCs only at an early time-point ( 15 min ) . Positive_regulation MAPK11 TNF 14654378 1176826 These findings suggest that the pre-ischemic *activation* of [p38-MAPK] by does not contribute to cardioprotection afforded by this agent . Positive_regulation MAPK11 TNF 15002040 1265076 Consistent with the abrogation of osteoclastogenic effect of DcR3 by TNFR-Fc , DcR3 treatment can *induce* osteoclastogenic cytokine release through ERK and p38 [MAPK] signaling pathways . Positive_regulation MAPK11 TNF 15139014 1246955 The increase in release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not [mitogen activated protein kinase (MAPK)] , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation MAPK11 TNF 15191888 1295237 Treatment of endothelial cells with SphK1 siRNA suppressed *induced* increase in MCP-1 mRNA levels , MCP-1 protein secretion , and activation of p38 [MAPK] . Positive_regulation MAPK11 TNF 15212763 1262312 Interestingly , Ad5NIK , but not , *induces* RelA S536 and p38 [mitogen activated protein kinase (MAPK)] phosphorylation in IKKgamma ( -/- ) cells . Positive_regulation MAPK11 TNF 15233873 1269388 A. semen also inhibited the expression of and the *activation* of [mitogen activated protein kinase] , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation MAPK11 TNF 15240695 1270280 TNF activates Syk protein tyrosine kinase leading to *induced* [MAPK] activation , NF-kappaB activation , and apoptosis . Positive_regulation MAPK11 TNF 15240695 1270300 TNF induced Syk activation was abolished by piceatannol ( Syk-selective inhibitor ) , which led to the suppression of induced *activation* of c- JNK , p38 MAPK , and p44/p42 [MAPK] . Positive_regulation MAPK11 TNF 15240695 1270316 Jurkat cells that did not express Syk ( JCaM1 , JCaM1/lck ) showed lack of *induced* Syk , JNK , p38 [MAPK] , and p44/p42 MAPK activation , as well as TNF induced IkappaBalpha phosphorylation , IkappaBalpha degradation , and NF-kappaB activation . Positive_regulation MAPK11 TNF 15240695 1270347 Overall , our results demonstrate that Syk activation plays an essential role in induced *activation* of JNK , p38 [MAPK] , p44/p42 MAPK , NF-kappaB , and apoptosis . Positive_regulation MAPK11 TNF 15240725 1270455 p38 [MAPK] was *activated* by and oxidants in nonadherent conditions i.e. , with 10 mM EDTA . Positive_regulation MAPK11 TNF 15240725 1270469 Finally , p38 [MAPK] *activation* by was blocked by diphenylene iodonium , an inhibitor of flavoprotein oxidoreductase , and by the free radical scavenger N-acetylcystein . Positive_regulation MAPK11 TNF 15265936 1275731 Besides NF-kappa B , celecoxib also suppressed *induced* JNK , p38 [MAPK] , and ERK activation . Positive_regulation MAPK11 TNF 15290420 1278548 Halothane or isoflurane augmented the LPS- and *induced* activation of p38 [MAPK] . Positive_regulation MAPK11 TNF 15304089 1284477 DNCB , NiSO ( 4 ) and *activated* p38 [mitogen activated protein kinases (MAPK)] and c-jun N-terminal kinase ( JNK ) . Positive_regulation MAPK11 TNF 15322069 1333419 We have also investigated the phosphorylation of p42/44 [MAPK] and *upregulation* of RhoA protein by . Positive_regulation MAPK11 TNF 15452110 1341990 In contrast , *induced* p42/p44 [MAPK] activation and CD54 expression remained unaltered . Positive_regulation MAPK11 TNF 15589482 1356210 In addition , luteolin inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , IkappaB degradation , and NF-kappaB activation . Positive_regulation MAPK11 TNF 15659876 1350302 The anabolic effect of was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an extracellular regulated kinases (ERK) . Positive_regulation MAPK11 TNF 15696169 1372156 Using TCPTP-deficient fibroblasts , we show here that TCPTP regulates *induced* [MAPK] but not NF-kappaB signaling . Positive_regulation MAPK11 TNF 15696169 1372199 These results link TCPTP and Src tyrosine kinases to the selective regulation of *induced* [MAPK] signaling and identify a previously unknown mechanism for modulating inflammatory responses mediated by TNF . Positive_regulation MAPK11 TNF 15703956 1497466 *Activation* of p38 [mitogen activated protein (MAP) kinase] and phosphatidylinositol 3-kinase (PI3K) by was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation MAPK11 TNF 15792609 1386792 By stimulation of in AM-1 cells , the phosphorylation of Akt ( Ser473 ) and p44/42 [mitogen activated protein kinase (MAPK)] ( Thr202/Tyr204 ) was markedly *increased* in TNFalpha concentration and time dependent manner . Positive_regulation MAPK11 TNF 15792609 1386805 Pretreatment with U0126 , mitogen activated extracellular regulated kinase ( MEK) 1/2 inhibitor , prior to TNFalpha stimulation , specifically inhibited *induced* phosphorylation of p44/42 [MAPK] ( Thr202/Tyr204 ) in AM-1 cells . Positive_regulation MAPK11 TNF 15792609 1386821 Meanwhile , pretreatment with LY294002 , phosphatidylinositol-3-OH kinase (PI3K) inhibitor , could inhibit both *induced* phosphorylation of Akt ( Ser473 ) and p44/42 [MAPK] ( Thr202/Tyr204 ) . Positive_regulation MAPK11 TNF 15823554 1393910 Furthermore , potently *activated* p38 [MAPK] , JNK , and NF-kappaB . Positive_regulation MAPK11 TNF 15837794 1432547 Expression of this protein inhibited induced *activation* of NFkappaB , JNK , and p38 [MAPK] and sensitized the cells to TNF induced apoptosis . Positive_regulation MAPK11 TNF 15845648 1425545 *induces* a more than tenfold increase in p38 [mitogen activated protein kinase (MAPK)] but not extracellular signal regulated kinase phosphorylation . Positive_regulation MAPK11 TNF 15870903 1405545 In addition , GA inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , I kappa B alpha degradation , and NF-kappa B activation . Positive_regulation MAPK11 TNF 16009485 1441399 Moreover , p44/42 [mitogen activated protein kinase] appears to partly *mediate* the negative effect of insulin but not on ATGL . Positive_regulation MAPK11 TNF 16023081 1441586 Ellagic acid inhibited IL-1beta- and induced *activation* of activator protein-1 and mitogen activated protein kinases ( extracellular signal regulated kinase , c-Jun N-terminal kinase and p38 [mitogen activated protein kinase] ) , but not of nuclear factor-kappaB . Positive_regulation MAPK11 TNF 16025396 1435609 *activated* the phosphorylation of p44/42 MAPK , p38 [MAPK] , SAPK/JNK and Akt in mesangial cells . Positive_regulation MAPK11 TNF 16025396 1435625 PGE1 inhibited the *induced* phosphorylation of SAPK/JNK and Akt , but not p44/42 MAPK and p38 [MAPK] . Positive_regulation MAPK11 TNF 16080915 1442765 Comparative gene array analysis of *induced* [MAPK] and NF-kappaB signaling pathways between retinal ganglion cells and glial cells . Positive_regulation MAPK11 TNF 16140562 1499251 These results suggested that TNFalpha induced both cell survival and apoptosis pathways in ameloblastoma and potential of TNFalpha in inducing apoptosis can be improved by inhibiting *induced* Akt and p44/42 [mitogen activated protein kinase (MAPK)] cell survival pathways . Positive_regulation MAPK11 TNF 16275991 1480296 Angiotensin II , , or epidermal growth factor *induced* [MAPK] phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation MAPK11 TNF 16291729 1526068 *Activation* of [MAPK] and Akt by anti-HER2/neu inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation MAPK11 TNF 16314440 1486997 treatment *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation in NPCs , and SB202190 , an inhibitor of p38 MAPK , blocked TNF-alpha induced chemokine production . Positive_regulation MAPK11 TNF 16325162 1511662 Furthermore , APE1/ref-1 overexpression inhibited the *induced* increase in intracellular superoxide and p38 [MAPK] phosphorylation . Positive_regulation MAPK11 TNF 16452991 1611732 Western blots showed that IL-1beta and *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK11 TNF 16517732 1530932 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of , but not IL-6 , *requires* the activity of p38 [MAPK] . Positive_regulation MAPK11 TNF 16573652 1556134 HA-mediated production *required* p38 [MAPK] , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation MAPK11 TNF 16682409 1584055 Further , the deletion of NQO1 abolished *induced* c-Jun N-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] activation . Positive_regulation MAPK11 TNF 16781693 1585613 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and and the *activation* of [MAPK] 's are potentially positive signals for IL-10 production . Positive_regulation MAPK11 TNF 16798728 1638532 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Positive_regulation MAPK11 TNF 16875982 1593560 *activates* [p38-MAPK] , a stress-responsive kinase implicated in contractile depression and cardiac injury . Positive_regulation MAPK11 TNF 16875982 1593574 Under conditions of constant coronary flow , the [p38-MAPK] activation and contractile depression *induced* by , though attenuated , remained sensitive to the absence of MKK3 or the presence of SB203580 . Positive_regulation MAPK11 TNF 16875982 1593588 *activates* [p38-MAPK] in the intact heart and in isolated cardiac myocytes through MKK3 . Positive_regulation MAPK11 TNF 16982923 1617360 Compared with wild-type cells , MIF-deficient cells were hyporesponsive to IL-1- and *induced* [MAPK] activity , AP-1 activity , and cellular proliferation , while NF-kappaB function was preserved . Positive_regulation MAPK11 TNF 17070777 1649828 Inhibition of Syk down-regulated *induced* p38 and p44/42 [MAPK] phosphorylation and nuclear translocation of p65 NF-kappaB . Positive_regulation MAPK11 TNF 17099067 1676198 Importantly , Dex is able to increase the expression of MKP-1 , which causes an inactivation of *induced* p38 [MAPK] and mediates inhibition of E-selectin expression . Positive_regulation MAPK11 TNF 17126899 1677671 Stimulation of ECs with *induced* rapid increases in the phosphorylation of their mitogen activated protein kinases ( MAPKs ) [ extracellular signal regulated kinase ( ERK ) , c-Jun-NH2-terminal kinase (JNK) , and p38 [MAPK] ] ; Positive_regulation MAPK11 TNF 17126905 1686543 Differential regulation of and GM-CSF *induced* activation of P38 [MAPK] in neutrophils and eosinophils . Positive_regulation MAPK11 TNF 17138860 1653544 The role of delta-PKC in *mediated* activation of [MAPK] is not known . Positive_regulation MAPK11 TNF 17138860 1653570 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 MAPK are involved in TNF antiapoptotic signaling and whether delta-PKC is a key regulator of [MAPK] *activation* by . Positive_regulation MAPK11 TNF 17138860 1653596 In human neutrophils , *activated* both p38 [MAPK] and ERK1/2 principally via TNFR-1 . Positive_regulation MAPK11 TNF 17158449 1694248 A green fluorescent protein fusion protein containing the last 100 residues of TAK1 ( TAK1-C100 ) abolished the interaction of endogenous TAB2/TAB3 with TAK1 , the phosphorylation of TAK1 , and prevented the activation of IKK and [MAPK] *induced* by IL-1 , , and RANKL . Positive_regulation MAPK11 TNF 17161959 1694536 Upon examination of the signaling components , we found that was a potent *activator* of p38 , p44/42 , p54/46 [MAPK] , and IkappaBalpha ( IkappaBalpha ) . Positive_regulation MAPK11 TNF 17172975 1679384 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the [MAPK] , and production of . Positive_regulation MAPK11 TNF 17172975 1679410 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the [MAPK] , and production of . Positive_regulation MAPK11 TNF 17189827 1680161 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Positive_regulation MAPK11 TNF 17202326 1680812 Augmented lipopolysaccharide induced production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK11 TNF 17202326 1680838 In this study , we show that augmented LPS induced production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK11 TNF 17218473 1732511 The RhoA inhibitor C3 exoenzyme and the ROCK inhibitor Y-27632 both attenuated induced [MAPK] *activation* and blocked AR expression in HIMEC . Positive_regulation MAPK11 TNF 17220297 1703051 TRAF2 and ASK1 play essential roles in *induced* [mitogen activated protein kinase] signaling . Positive_regulation MAPK11 TNF 17258890 1725448 The effects of and FasL on GrB expression were specifically *mediated* by [p38MAPK] ( Mitogen-activated-protein-kinase ) activation . Positive_regulation MAPK11 TNF 17425653 1748781 The percentage increases in IL-18 induced phosphorylation of extracellular signal regulated kinase ( ERK ) in Th cells of NDN and DN were significantly higher than controls ( P < 0.05 ) , while the percentage increase in *induced* phosphorylation of p38 [MAPK] in monocytes and IL-18 induced phosphorylation of p38 MAPK in Th cells and monocytes were significantly higher in NDN patients than controls . Positive_regulation MAPK11 TNF 17438131 1742769 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation MAPK11 TNF 17438336 1749073 FAK promoted *stimulated* [MAPK] activation needed for maximal IL-6 production . Positive_regulation MAPK11 TNF 17438336 1749091 Analysis of FAK ( -/- ) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity , Tyr-397 phosphorylation , and the Pro-712/713 proline-rich region of FAK were required for *stimulated* [MAPK] activation and IL-6 production . Positive_regulation MAPK11 TNF 17446186 1749508 *increased* p38 [MAPK] phosphorylation , potently stimulated IRS-1 serine phosphorylation , and blunted insulin stimulated IRS-1 tyrosine and Akt phosphorylation and eNOS activity . Positive_regulation MAPK11 TNF 17531219 1762168 On the other hand , aloe emodin did not affect *induced* activation of p38 [mitogen activated protein kinase] or generation of reactive oxygen species . Positive_regulation MAPK11 TNF 17607712 1798187 Although *induced* the activation of p38 [MAPK] , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation MAPK11 TNF 17725582 1801632 MAC inhibited induced p38 [mitogen activated protein kinase] *activation* and cell death in cultured Schwann cells . Positive_regulation MAPK11 TNF 17895408 1823963 IA did not interfere with induced *activation* of c-Jun N-terminal kinase (JNK) and p38 [mitogen activated protein kinase] . Positive_regulation MAPK11 TNF 17942934 1814212 Deletion of NQO2 also abolished induced c-Jun NH2-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] *activation* . Positive_regulation MAPK11 TNF 17994109 1851160 triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 [MAPK] , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation MAPK11 TNF 18039275 1828526 Further downstream in this axis of signalling , blockade *reduces* only acute bronchoconstriction , while [MAPK] inhibition abrogates completely endotoxin induced inflammation . Positive_regulation MAPK11 TNF 18060043 1853600 In cultures of Schwann cells , astrocytes , and microglia , sLRP-alpha inhibited induced *activation* of p38 [MAPK] and ERK/MAPK . Positive_regulation MAPK11 TNF 18061162 1861514 We demonstrate that *induced* proliferation of C4HD murine mammary tumor cells and of T47D cells through the activation of p42/p44 [MAPK] , JNK , PI3-K/Akt pathways and nuclear factor-kappa B (NF-kappa B) transcriptional activation . Positive_regulation MAPK11 TNF 18091748 1847365 *induced* phosphorylation of extracellular signal regulated kinase ( ERK ) and Akt , but not p38 [mitogen activated protein kinase (MAPK)] , was attenuated by nicardipine , cilnidipine , benidipine , efonidipine , and azelnidipine . Positive_regulation MAPK11 TNF 18227157 1884360 It was shown that these three proteins could ( i ) induce expression of and tissue factor and ( ii ) *induce* phosphorylation of p44/42 [mitogen activated protein kinases (MAPK)] and activation of early growth response factor 1 (Egr-1) . Positive_regulation MAPK11 TNF 18258304 1884794 However , over-expression of a dominant negative form of Rac strongly inhibited *induced* p42/44 [MAPK] kinase activation , but had little effect upon JNK and no effect upon p38 MAPK activity . Positive_regulation MAPK11 TNF 18287053 1872487 Here , we show that the murine CMV M45 protein binds to RIP1 and inhibits induced *activation* of NF-kappaB , p38 [MAPK] , and caspase independent cell death . Positive_regulation MAPK11 TNF 18287248 1896523 Flavopiridol suppresses *induced* activation of activator protein-1 , c-Jun N-terminal kinase , p38 [mitogen activated protein kinase (MAPK)] , p44/p42 MAPK , and Akt , inhibits expression of antiapoptotic gene products , and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells . Positive_regulation MAPK11 TNF 18314542 1931904 P < 0.05 ) , and MKP-1 up-regulation was temporally related to the inhibition of *induced* p38 [MAPK] phosphorylation . Positive_regulation MAPK11 TNF 18336852 1912238 *stimulated* phosphorylation of p42/p44 [MAPK] and JNK were attenuated by pretreatment with the inhibitors U0126 and SP600125 or transfection with dominant negative mutants of DeltaERK and DeltaJNK . Positive_regulation MAPK11 TNF 18364436 1912766 We , for the first time , demonstrate that binding of staphylococcal enterotoxin B to MHC-II results in activation of TNF-alpha converting enzyme , epidermal growth factor receptor , [p38MAPK] , and NF-kappaB *inducing* biphasic production . Positive_regulation MAPK11 TNF 18443205 1938524 Conversely , *induced* increases in insulin receptor substrate-1 serine phosphorylation ( Ser ( 312 ) ) , Jun NH ( 2 ) -terminal kinase phosphorylation , and extracellular signal related kinase-1/2 [mitogen activated protein kinase (MAPK)] phosphorylation were unaltered by siRNA mediated IKKbeta reduction . Positive_regulation MAPK11 TNF 18518937 1971918 Although Cot/Tpl2 was phosphorylated in IRI and in the cultured tubular epithelial cells (TEC) after stimulation with LPS and hydrogen peroxide , there were no significant differences in terms of production , neutrophil infiltration or [MAPK] *activation* between Cot/Tpl2 ( +/+ ) and Cot/Tpl2 ( -/- ) mice . Positive_regulation MAPK11 TNF 18636175 1937268 Furthermore , glucosamine inhibited the *induced* phosphorylation of [p38MAPK] and NF-kappaB p65 , and the nuclear translocation of NF-kappaB in the cells . Positive_regulation MAPK11 TNF 18653803 1960515 PMA stimulated nSMase2 translocation was independent of p38 MAPK , and neither PKC inhibitors nor small interfering RNA had significant effects on *stimulated* p38 [MAPK] activation , indicating that PKC-delta does not act through p38 MAPK in regulating nSMase2 . Positive_regulation MAPK11 TNF 18710428 2028199 As for the signalling pathway , stimulation *led* to the phosphorylation of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and translocation of nuclear factor kappaB (NF-kappaB) ( p65 ) into the nuclei . Positive_regulation MAPK11 TNF 18710428 2028219 These data suggest that interaction *leads* to the phosphorylation of Erk1/2 and [p38MAPK] and nuclear translocation of NF-kappaB , which is closely associated with the production and activation of MMP-9 in cultured CC cells of HuCTT-1 and CCKS-1 . Positive_regulation MAPK11 TNF 18768892 1957213 Consistently , Nod2-null macrophages tolerant to LPS and MDP showed enhanced production of and IL-6 as well as increased NF-kappaB and [MAPK] *activation* in response to the dipeptide KF1B , the Nod1 agonist . Positive_regulation MAPK11 TNF 18948845 2053238 Hypertonic saline did not alter *induced* p38 [mitogen activated protein kinase] phosphorylation or constitutive vascular endothelial growth factor expression , suggesting that the observed inhibition is not a generalized suppression of protein phosphorylation or cellular function . Positive_regulation MAPK11 TNF 19100731 2031219 at 30 ng/ml significantly *increased* phosphorylation of receptor tyrosine kinase ( 175 kDa ) and p42 [mitogen activated protein (MAP) kinase] . Positive_regulation MAPK11 TNF 19130554 2025298 Stimulation of HIMEC with *triggered* phosphorylation of the [MAPK] , and up-regulation of VCAM-1 , FKN and ICAM-1 . Positive_regulation MAPK11 TNF 19234337 2079508 Analysis of downstream signals showed that inhibition of NAD(P)H oxidase partially inhibited NF-kappaB activation but did not reduce CCL2 mRNA stability or prevent *induced* phosphorylation of [p38MAPK] . Positive_regulation MAPK11 TNF 19275968 2072842 *stimulated* the phosphorylation levels of p38 [MAPK] , JNK , ERK1/2 and Akt in vascular endothelial cells . Positive_regulation MAPK11 TNF 19289468 2073036 The requirement for MADD was highly specific for induced *activation* of [MAPK] but not the related JNK and p38 kinases . Positive_regulation MAPK11 TNF 19371952 2081760 Of note , the IFN-gamma plus *stimulated* activation of p38 [MAPK] was suppressed following incubation with forskolin or DBcAMP alone . Positive_regulation MAPK11 TNF 19410630 2089693 By transfection of TAK1 siRNA , *induced* phosphorylation of IkappaBalpha , JNK1/2 , and [p38MAPK] , as well as IL-6 or IL-8 expression , were repressed . Positive_regulation MAPK11 TNF 19427347 2106792 *induced* the phosphorylation of p38 [mitogen activated protein (MAP) kinase] , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation MAPK11 TNF 19429670 2106859 Ang II and clearly *enhanced* ERK and [p38MAPK] phosphorylation . Positive_regulation MAPK11 TNF 19563733 2122006 Finally , EZS inhibited *induced* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phosphorylation . Positive_regulation MAPK11 TNF 19648110 2138329 This correlates with reduced *stimulated* p38 [MAPK] phosphorylation . Positive_regulation MAPK11 TNF 19648110 2138344 Repression of *induced* p38 [MAPK] phosphorylation , NF-kappaB dependent transcription , and IL-8 expression by dexamethasone are sensitive to transcriptional or translational inhibitors . Positive_regulation MAPK11 TNF 19648110 2138415 Thus , MKP-1 attenuates *dependent* activation of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Positive_regulation MAPK11 TNF 19648110 2138442 Small interfering RNA knockdown of dexamethasone induced MKP-1 expression partially reverses the repression of *activated* p38 [MAPK] , demonstrating that MKP-1 participates in the dexamethasone dependent repression of this pathway . Positive_regulation MAPK11 TNF 19788916 2163920 ( TNF-alpha ) and H ( 2 ) O ( 2 ) *activate* [mitogen activated protein kinase (MAPK)] in SH-SY5Y cells within 5 min and this activation is completely blocked by DLPC ( 12 microM ) . Positive_regulation MAPK11 TNF 19877072 2160709 CpdA also displayed profound effects on induced [MAPK] *activation* . Positive_regulation MAPK11 TNF 19877072 2160726 In sharp contrast , DEX did not affect *induced* IKK phosphorylation , IkappaBalpha degradation , p65 nuclear translocation , or [MAPK] activation in RA FLS . Positive_regulation MAPK11 TNF 19889458 2197301 Calpain inhibition induces random migration in TNF-alpha stimulated cells and prevents the generation of reactive oxygen species , but does not alter *mediated* activation of p38 [MAPK] and ERK MAPK . Positive_regulation MAPK11 TNF 20231691 2237856 TNF-alpha treatment resulted in the phosphorylation of p38 MAPK and its downstream target , MAPK activated protein kinase-2 , but IFN-gamma did not affect the levels of [MAPK] and MAPK activated protein kinase-2 phosphorylation *induced* by . Positive_regulation MAPK11 TNF 20489729 2327418 induced *activation* of p38 [MAPK] and the production of inducible nitric oxide synthase were suppressed in ASK1-deficient Müller glial cells . Positive_regulation MAPK11 TNF 20646342 2292547 Effects of budesonide on P38 [MAPK] activation , apoptosis and IL-8 secretion , *induced* by and Haemophilus influenzae in human bronchial epithelial cells . Positive_regulation MAPK11 TNF 20646342 2292575 *induced* a significant increase in p38 [MAPK] phosphorylation . Positive_regulation MAPK11 TNF 20693316 2351476 In four of the six donors , basal and *induced* ERK and p38 [MAPK] activation were higher in ASMA than ASMNA cells . Positive_regulation MAPK11 TNF 20696856 2351507 Surprisingly , replenishment with exogenous GSH normalizes both *dependent* NF-?B as well as [MAPK] signaling and rescues hepatocytes from FKB induced death . Positive_regulation MAPK11 TNF 20951126 2364950 Taken together , this study provided first evidence demonstrating that TRAIL- , , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK11 TNF 21123734 2377720 The ability of CO to inhibit *induced* ERK1/2 and p38 [MAPK] activities in an Akt dependent manner appears to be the key element in ROS dependent survival of endothelial cells during TNF-a mediated brain inflammatory disease . Positive_regulation MAPK11 TNF 21181166 2499605 IL-1ß and *activated* the intracellular mitogen activated protein kinases ( MAPKs ) : p44/42 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) as well as nuclear factor-?B ( NF-?B ) in osteoblasts . Positive_regulation MAPK11 TNF 21285293 2425720 Inhibitors of NADPH oxidase and/or p47phox siRNA diminished ROS production and COX-2 expression as well as phosphorylation of p38 [mitogen activated protein kinase] ( p38MAPK ) and Akt *mediated* either by AS serum or by . Positive_regulation MAPK11 TNF 21336587 2457987 Effects of preconditioning with sevoflurane on induced permeability and *activation* of p38 [MAPK] in rat pulmonary microvascular endothelial cells . Positive_regulation MAPK11 TNF 21422246 2416766 Interestingly , all PHA-L ( high ) DCs displayed a strongly reduced responsiveness to *induced* [p38-MAPK] activation compared with PHA-L ( low ) DCs , indicating differences in PHA-L binding capacities between DCs with different inflammatory properties . Positive_regulation MAPK11 TNF 21422246 2416780 Moreover , hybrid-type , but not complex-type , N-glycans are required for *induced* [p38-MAPK] activation and subsequent phenotypic maturation of BMDCs ( MHC-II , CD86 , CCR7 upregulation ) . Positive_regulation MAPK11 TNF 21520062 2423119 Here , we report that *induced* cPLA(2) protein and mRNA expression , PGE ( 2 ) production , and phosphorylation of p42/p44 MAPK , p38 [MAPK] , and JNK1/2 , which were attenuated by pretreatment with a ROS scavenger [ N-acetyl-L-cysteine , ( NAC ) ] and the inhibitors of NADPH oxidase [ apocynin (APO) and diphenyleneiodonium chloride ( DPI ) ] , MEK1/2 ( U0126 ) , p38 MAPK ( SB202190 ) , and JNK1/2 ( SP600125 ) or transfection with siRNA of Nox2 , p47(phox) , MEK1 , p42 , p38 , or JNK2 . Positive_regulation MAPK11 TNF 21545687 2554378 significantly *induced* phosphorylation of p38 [MAPK] , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation MAPK11 TNF 21894146 2510864 Vehicle and untreated NTN exhibited heavy proteinuria and glomerular thrombosis at 24 h with P-selectin and fibrin immunostaining within capillaries , glomerular macrophage and T cell infiltration , *activation* of JNK and p38 [MAPK] signalling , and upregulation of glomerular mRNA levels of pro-inflammatory molecules ( , NOS2 , MMP-12 and CCL2 ) . Positive_regulation MAPK11 TNF 22002864 2526325 These results suggest that H ( 2 ) O ( 2 ) -induced secretion of *increases* apoptosis of cardiac myocytes through ROS dependent activation of p38 [MAPK] . Positive_regulation MAPK11 TNF 22227193 2544574 Casuarinin significantly inhibited induced *activation* of NF-?B , STAT1 , and p38 [MAPK] . Positive_regulation MAPK11 TNF 22230399 2519474 KMUP-1 inhibited *induced* iNOS and U46619 induced PDE-5A and phospho-p38 [MAPK] in normoxia , confirming its anti-proinflammatory action . Positive_regulation MAPK11 TNF 22250084 2551209 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Positive_regulation MAPK11 TNF 22343222 2617808 Using immunohistological techniques , we showed a higher epithelial expression of , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator [protein-1/mitogen activated protein kinase] signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation MAPK11 TNF 22525504 2522570 *up-regulated* the phosphorylation levels of p38 [MAPK] and increased the translocation of NF-kB p65 protein into the nucleus , also proved by immunofluorescence staining . Positive_regulation MAPK11 TNF 22526394 2595911 also *increased* the production of inducible nitric oxide synthase (iNOS) , nitric oxide ( NO ) , and intercellular adhesion molecule 1 ( ICAM-1 ) through activation of p38 [mitogen activated protein kinase (MAPK)] from HT-29 cells . Positive_regulation MAPK11 TNF 22773691 2659900 induced *activation* of p38 [MAPK] and NF-?B was attenuated by miR-140-3p mimic . Positive_regulation MAPK11 TNF 22819264 2646093 CORM-2 inhibited induced *activation* of p38 [MAPK] , ERK1/2 , JNK , and NF-?B signaling pathways in HUVECs . Positive_regulation MAPK11 TNF 22947346 2678659 *induced* phosphorylated p38 [mitogen activated protein kinase] levels were increased in ASMCs from patients with severe asthma compared with those from patients with nonsevere asthma and nonasthmatic subjects , whereas TNF-a induced phosphorylated c-Jun N-terminal kinase and phosphorylated extracellular signal related kinase levels were increased in all asthmatic groups . Positive_regulation MAPK11 TNF 22988345 2674353 The EGF receptor and HER2 participate in dependent [MAPK] *activation* and IL-8 secretion in intestinal epithelial cells . Positive_regulation MAPK11 TNF 22988345 2674381 As the epidermal growth factor receptor (EGFR) is a known transducer of proliferative signals and a potent activator of MAPKs , we hypothesized that the EGFR participates in dependent [MAPK] *activation* and IL-8 secretion by intestinal epithelial cells ( IECs ) . Positive_regulation MAPK11 TNF 23071098 2720901 Mixed-effects modeling analysis of our data was vital for ascertaining that IL-1a and TGF-a treatment increased the activities of more pathways than IL-6 and TNF-a and that TGF-a and *increased* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phospho-protein levels in a synergistic manner . Positive_regulation MAPK11 TNF 23142559 2722784 Western blot analysis revealed that pilocarpine and physostigmine enhanced the *induced* phosphorylation of ERK1/2 and p38 [MAPK] and the degradation of I?Ba . Positive_regulation MAPK11 TNF 23333920 2758382 Interestingly , IL-27 promoted the basal and enhanced *induced* phosphorylation of p38 [MAPK] and Akt , but not I?Ba . Positive_regulation MAPK11 TNF 23353699 2754238 We further demonstrated that markedly *stimulated* p38 [MAPK] , p42/p44 MAPK , and JNK1/2 phosphorylation via a c-Src/EGFR , PDGFR/PI3K/Akt pathway . Positive_regulation MAPK11 TNF 23354775 2770387 p38a [mitogen activated protein kinases (MAPK)] may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , , interleukin-1ß , and oxidative stress . Positive_regulation MAPK11 TNF 23664593 2838381 sFGL2 secretion by CD4 ( + ) T cells can be *induced* with and IFN-? stimulation through [MAPK] signaling in renal allograft AR . Positive_regulation MAPK11 TNF 23861542 2817215 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Positive_regulation MAPK11 TNF 23884101 2821466 Furthermore , P. vulgaris extract suppressed *induced* phosphorylation of p38 [mitogen activated protein kinase (MAPK)] and extracellular signal regulated kinase ( ERK ) . Positive_regulation MAPK11 TNF 23935096 2840761 In contrast , loss of SK1 prevented *induced* phosphorylation of p38 [MAPK] , and inhibition of p38 MAPK , like SK1 knockdown , also potentiates RANTES induction . Positive_regulation MAPK11 TNF 24069158 2846991 We showed that markedly *stimulated* p42/p44 MAPK , p38 [MAPK] , and JNK1/2 phosphorylation which were attenuated by their respective inhibitors . Positive_regulation MAPK11 TNF 24080497 2902537 Consistently , DUSP1 promotes apoptosis and decreases NF-?B activity in cells in which p38 [MAPK] is *induced* by treatment . Positive_regulation MAPK11 TNF 24089494 2848148 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed receptor 1 and *requires* activation of p38 [MAPK] , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation MAPK11 TNF 24361597 2911243 We further demonstrated that *stimulated* ERK1/2 , p38 [MAPK] , and JNK1/2 phosphorylation via a c-Src dependent PDGFR/PI3K/Akt pathway . Positive_regulation MAPK11 TNF 24378531 2911771 TRAF2 has been previously reported to be required for induced *activation* of p38 [MAPK] . Positive_regulation MAPK11 TNF 24441870 2922931 We showed that markedly *stimulated* Jak2 , PDGFR , Akt , and p42/p44 [MAPK] phosphorylation , which were attenuated by their respective inhibitors . Positive_regulation MAPK11 TNF 24441870 2922949 In addition , *induced* p42/p44 [MAPK] phosphorylation was reduced by AG1296 or LY294002 . Positive_regulation MAPK11 TNF 24441870 2922985 On the other hand , could *induce* Akt and p42/p44 [MAPK] translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation MAPK11 TNF 24446489 2912936 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Positive_regulation MAPK11 TNF 24489443 2884790 Finally , by investigating the intracellular pathways involved in promoting the VEC release of cytokines/chemokines , which are targeted by natural anti-inflammatory compounds , we documented that aLipoic acid significantly counteracted *induced* NF-?B and [p38/MAPK] activation while the effects of Ginkgo biloba appeared to be predominantly mediated by Akt . Positive_regulation MAPK11 TNF 24750790 2936563 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas and NO production *required* all three [MAPK] . Positive_regulation MAPK11 TNF 7689564 225762 *induced* activation and increased tyrosine phosphorylation of [mitogen activated protein (MAP) kinase] in human fibroblasts . Positive_regulation MAPK11 TNF 7689564 225775 induced *activation* of [MAPK] was demonstrated by its enhanced ability to phosphorylate myelin basic protein in vitro and by a characteristic shift in the electrophoretic mobility of MAPK proteins . Positive_regulation MAPK11 TNF 7722327 301755 *induces* tyrosine phosphorylation of [mitogen activated protein kinase] in adherent human neutrophils . Positive_regulation MAPK11 TNF 7722327 301781 PMN pretreatment with genistein , a tyrosine kinase inhibitor , inhibited the *induced* increase in tyrosine phosphorylation and [MAPK] activity . Positive_regulation MAPK11 TNF 8626494 360274 Inhibition of *induced* p42/p44 [mitogen activated protein kinase] activation by sodium salicylate . Positive_regulation MAPK11 TNF 8626494 360288 *activates* both p42 and p44 [mitogen activated protein kinases (MAPK)] in human FS-4 fibroblasts , cells for which TNF is mitogenic . Positive_regulation MAPK11 TNF 8626494 360301 We now show that *activates* p42 [MAPK] in two cell lines whose growth is inhibited by TNF . Positive_regulation MAPK11 TNF 8626494 360316 We now show that neither phorbol ester-sensitive protein kinase C nor Gialpha link TNF to p42/p44 MAPK activation , because pretreatment of FS-4 cells with phorbol ester to down-regulate protein kinase C or pretreatment with pertussis toxin to block Gialpha does not inhibit p42/p44 [MAPK] *activation* by . Positive_regulation MAPK11 TNF 8626494 360336 To further analyze MAPK activation in FS-4 cells , we compared p42/p44 [MAPK] *activation* by and epidermal growth factor (EGF) . Positive_regulation MAPK11 TNF 8626494 360361 Elucidation of the mechanism whereby sodium salicylate blocks induced p42/p44 [MAPK] *activation* may help to clarify TNF activated signaling pathways . Positive_regulation MAPK11 TNF 8662702 367180 additionally *caused* rapid p38 and JNK-1 [mitogen activated protein kinase] activation and efficient NF-kappaB translocation , which could not be achieved even by high levels of ceramide . Positive_regulation MAPK11 TNF 9106254 424409 The increases in [MAPK] *induced* by and IL-1 were similar to the increases induced by PMA and PDGF-AB . Positive_regulation MAPK11 TNF 9106254 424435 Our findings indicate that and IL-1 activate parallel signal transduction pathways in human neuroma fibroblasts , and that they are relatively stronger *activators* of [MAPK] than of SAPK . Positive_regulation MAPK11 TNF 9315666 456098 , an inhibitor of insulin stimulated adipogenesis , *activated* [MAPK] in 3T3-L1 cells . Positive_regulation MAPK11 TNF 9439626 482867 *increased* ERK1 and ERK2 [MAPK] phosphorylation . Positive_regulation MAPK11 TNF 9439626 482893 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic effect of *requires* protein tyrosine phosphorylation and [MAPK] activation . Positive_regulation MAPK11 TNF 9593119 505483 The CAZ released endotoxin was similar to purified LPS with respect to the following biological activities in LPS-responsive C3H/HeN mice and LPS-hyporesponsive C3H/HeJ mice : lethal toxicity in GalN sensitized mice , in vitro induction of and NO production by macrophages , and [mitogen activated protein kinase] *activation* in macrophages . Positive_regulation MAPK11 TNF 9766635 538504 Our data suggest that and GM-CSF *activate* ERKs and p38 [MAPK] by different signal transduction pathways . Positive_regulation MAPK11 TNF 9770326 538800 Furthermore , *induction* of p42/p44 ERK and [p38-MAPK] phosphorylation , c-jun kinase activation , and IkappaBalpha degradation were normal . Positive_regulation MAPK11 TNF 9883899 558206 *Activation* of p42/p44 [mitogen activated protein kinases (MAPK)] and p38 MAPK by is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation MAPK11 TNF 9883899 558221 Here , we demonstrate that is *sufficient* to activate p42/p44 MAPK and p38 [MAPK] . Positive_regulation MAPK11 TNF 9930718 588835 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Positive_regulation MAPK11 TNF 9931102 588902 ( 100 U/mL ) transiently *activated* [MAPK] with a maximal induction 10 minutes after stimulation that returned to baseline levels by 2 hours after treatment . Positive_regulation MAPK11 TNF 9931102 588915 PD98059 also blocked *stimulated* [MAPK] activation in a concentration dependent manner , which is consistent with its inhibition of TNF-alpha directed migration . Positive_regulation MAPK11 TNF 9931102 588928 To identify which TNF-alpha receptor is involved in induced [MAPK] *activation* , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Positive_regulation MAPK11 TNF 9931102 588954 VSMC express both receptors , but *induced* [MAPK] activation was inhibited only by the TNF-R1 antibody . Positive_regulation MAPK11 TNF 9931102 588980 Both TRO and RSG inhibited migration , but neither attenuated induced [MAPK] *activation* , indicating that their antimigration activity was exerted downstream of MAPK . Positive_regulation MAPK11 TNFSF10 12969966 1185569 Among the intracellular pathways investigated , significantly *stimulated* the extracellular signal regulated kinase 1/2 ( ERK1/2 ) but not the [p38/mitogen activated protein kinase (MAPK)] or the c-Jun NH2-terminal kinase (JNK) pathway . Positive_regulation MAPK11 TNFSF10 20951126 2364951 Taken together , this study provided first evidence demonstrating that , TNF-a- , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK11 TNFSF10 21152872 2373391 Taken together , we show herein that the upstream molecule of the induced [MAPK] *activation* is MEKK , as opposed to ASK1 , via the mediation of its signal through JNK/p38 in a caspase-8 dependent manner . Positive_regulation MAPK12 ADRB2 11018034 752788 induced p38 [MAPK] *activation* is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes . Positive_regulation MAPK12 ADRB2 12509508 1038738 beta-Arrestin 1 is required for internalization and [mitogen activated protein (MAP) kinase] *activation* by the . Positive_regulation MAPK12 ADRB2 19047375 2023482 Hematopoietic protein tyrosine phosphatase mediates *induced* regulation of p38 [mitogen activated protein kinase] in B lymphocytes . Positive_regulation MAPK12 ADRB2 9038193 415363 In the present work , we report that stimulation of the A2A-adenosine receptor and of the *activates* [mitogen activated protein kinase] ( MAP kinase ) in human endothelial cells based on the following criteria : adenosine analogues and beta-adrenergic agonists cause an ( i ) increase in tyrosine phosphorylation of the p42 isoform and to a lesser extent of the p44 isoform of MAP kinase and ( ii ) stimulate the phosphorylation of myelin basic protein by MAP kinase; (iii) this is accompanied by a redistribution of the enzyme to the perinuclear region . Positive_regulation MAPK12 ADRB2 9363896 462906 We show that in HEK293 cells , *stimulation* of [mitogen activated protein (MAP) kinase] by the is mediated by the betagamma subunits of pertussis-toxin-sensitive G proteins through a pathway involving the non-receptor tyrosine kinase c-Src and the G protein Ras . Positive_regulation MAPK12 ALOX5 11807011 903506 In contrast , stress induced product formation and translocation of <5-LO> , as well as *activation* of p38 [MAPK] , occurred also after Ca ( ++ ) depletion . Positive_regulation MAPK12 ALOX5 21200133 2391684 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Positive_regulation MAPK12 ANGPT1 12039842 954279 Accordingly , ephrinB2 inhibited VEGF- and *induced* [Ras-MAPK] activities , whereas ephrinB2 did not alter VEGF induced Flk phosphorylation or Ang1 induced Tie2 phosphorylation . Positive_regulation MAPK12 ANGPT1 12213710 985639 Both VEGF and *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 [MAPK] . Positive_regulation MAPK12 ANGPT1 12213726 985709 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of and Ang-2 as well as the *activation* of [MAPK] , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation MAPK12 ANGPT1 16061664 1439067 *activated* [mitogen activated protein kinase (MAPK)] and phosphoinositide 3-kinase (PI3K) in IBE cells and HUVECs . Positive_regulation MAPK12 ANGPT1 16679392 1612151 Pretreatment with either DPI or apocynin also significantly attenuated *induced* Akt and p44/42 [MAPK] phosphorylation . Positive_regulation MAPK12 ANGPT1 16679392 1612167 Using mouse heart microvascular endothelial cells from wild-type ( WT ) mice and mice deficient in the p47(phox) component of NADPH oxidase ( p47 ( phox-/- ) ) , we found that although *stimulated* intracellular ROS , Akt and p42/44 [MAPK] phosphorylation , and cell migration in WT cells , the responses were strikingly suppressed in cells from the p47 ( phox-/- ) mice . Positive_regulation MAPK12 ANGPT1 20072135 2235285 *promoted* skin cell metabolism/viability , adhesion , and akt and [MAPK] ( p42/44 ) activations . Positive_regulation MAPK12 ANO1 22564524 2619160 *induces* [MAPK] and contributes directly to tumorigenesis and cancer progression . Positive_regulation MAPK12 CAPN8 21543591 2424089 Downstream , an Aß-mediated rise in p38 [mitogen activated protein kinase (MAPK)] activation was followed by downregulation of cAMP response element binding protein , and LTP impairment was *prevented* by inhibitors of p38 MAPK or . Positive_regulation MAPK12 CAPN8 24416390 2900957 Treatment with glutamate leads to early activation of NMDAR , which in turn leads to *mediated* cleavage of striatal enriched protein tyrosine phosphatase ( STEP ) and subsequent activation of p38 [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK12 CCL17 23711854 2792891 IL-33 induced the production of thymus and activation regulated and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 [MAPK] . Positive_regulation MAPK12 CCND1 11004713 735012 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping [ERK-MAPK] activation and c-Fos and *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation MAPK12 CCND1 12654183 1072982 [MAPK] may *induce* overexpression of protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation MAPK12 CCND1 15634644 1349552 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 [mitogen activated protein kinase] , and down-regulation of . Positive_regulation MAPK12 CCND1 16522728 1531456 We conclude that incretin induced beta-cell replication is dependent on cAMP/PKA , p42 [MAPK] and PI3K activities , which may *involve* transcriptional induction of . Positive_regulation MAPK12 CCND1 9537433 497556 Furthermore , in 25 of 26 cases of HCC which genomic DNA was available , 22 cases without genomic DNA amplification exhibited positive correlation , not only between protein expression of c-Fos and , but also between [MAPK/ERK] *activation* and cyclin D1 expression . Positive_regulation MAPK12 CD14 15625444 1349235 LPS interacts with the cell surface receptor , which generates transmembrane signals through Toll-like protein 4 *leading* to [mitogen activated protein kinase (MAPK)] p38 activation , cytokine synthesis , PMN beta2-integrin expression and oxidative burst . Positive_regulation MAPK12 CHI3L1 23755018 2797726 In addition , *induces* [FAK-MAPK] signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation MAPK12 CHI3L1 23972995 2836238 We also demonstrate that *activates* macrophage [mitogen activated protein kinase] , protein kinase B/AKT , and Wnt/ß-catenin signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation MAPK12 CLU 23051594 2702809 FOXL2 directly stimulates the Clu gene promoter , and we show that PTTG triggers ataxia telangiectasia mutated [kinase/IGF-I/p38MAPK] DNA damage/chromosomal instability signaling , which in turn also *induces* expression . Positive_regulation MAPK12 CTGF 11732999 885261 *induces* chondrocyte differentiation through a p38 [mitogen activated protein kinase] ( p38MAPK ) , and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase ( ERK ) . Positive_regulation MAPK12 CTGF 11732999 885275 In the proliferation phase , *induced* a approximately fivefold increase in the phosphorylation of p44/42 [MAPK/ERK] and a approximately twofold increase in that of p38 MAPK in an in vivo kinase assay . Positive_regulation MAPK12 CTGF 12218048 1012161 The inhibition of *induced* p42/44 [MAPK] or phosphatidylinositol 3-kinase (PI3K)/protein kinase B pathway activities abrogated the induction of fibronectin expression . Positive_regulation MAPK12 CTGF 16408113 1513476 *enhanced* the mRNA expression and protein release of fractalkine , MCP-1 , and RANTES , the expression of phospho ( P ) -p42/44 [mitogen activated protein kinase (MAPK)] , P-phosphoinositide 3-kinase (PI3-K) , P-Akt , and activity of nuclear factor-kappaB (NF-kappaB) in mesangial cells . Positive_regulation MAPK12 CTGF 16408113 1513502 P-p42/44 MAPK blockade inhibited the *induced* expression of P-p42/44 [MAPK] but not NF-kappaB , and partially decreased the levels of the above chemokines in supernatants . Positive_regulation MAPK12 CTGF 16522717 1531324 ( 3 ) *stimulated* dose dependent HSC adhesion and activity of p42/p44 [mitogen activated protein kinase] , the latter of which was antagonized by blocking the activity of focal adhesion kinase . Positive_regulation MAPK12 CTGF 16938382 1654123 No single module , but a mixture of the 4 modules provoked a significant activation of p38 [MAPK] in HCS-2/8 cells , which was *activated* by the full-length . Positive_regulation MAPK12 CTGF 19038999 2023081 Interestingly , CCN2-BMP-2 did not affect the *induced* phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Positive_regulation MAPK12 EDN2 12193071 980928 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Positive_regulation MAPK12 EDN2 12475899 1037766 *induced* a rapid phosphorylation of the [mitogen activated protein kinase (MAPK)/ERK] and increased collagen I gene activity in freshly isolated aortas . Positive_regulation MAPK12 EDN2 1280103 203033 rapidly *stimulates* [mitogen activated protein kinase] activity in rat mesangial cells . Positive_regulation MAPK12 EDN2 12855582 1149884 also *induced* the activation of p42/44 [mitogen activated protein kinase (MAPK)] in DCs . Positive_regulation MAPK12 EDN2 7509933 241600 *stimulates* [mitogen activated protein kinase] p42 activity through the phosphorylation of the kinase in rat mesangial cells . Positive_regulation MAPK12 EDN2 7849246 286724 *stimulates* [mitogen activated protein kinase] activity in mesangial cells through ETA . Positive_regulation MAPK12 EDN2 7943276 276391 has been shown to *activate* [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK12 EDN2 8836145 386165 In bovine airway smooth-muscle cells platelet derived growth factor ( PDGF ) and ( Et-1 ) *stimulate* sustained and comparable activation of [mitogen activated protein kinase] ( MAP kinase ) but display very different mitogenic efficacies , with PDGF inducing 50 times more DNA synthesis than Et-1 . Positive_regulation MAPK12 EFNB1 15502157 1347559 Further downstream of the signaling pathway , stimulation *led* to increased LAT ( linker for activation of T-cells ) phosphorylation and p44/42 and p38 [MAPK] activation . Positive_regulation MAPK12 EPHB2 10601128 574201 Tumor necrosis factor-alpha (TNF-alpha) alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only . Positive_regulation MAPK12 EPHB2 10872747 707024 Pre-treatment of the cells with PD98059 , a selective pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation MAPK12 EPHB2 11083274 750490 Tumor necrosis factor alpha , interleukin-1 (IL-1) , and IL-6 were the major inducers of , JNK , and p38 [MAPK] *activation* in cultured human synovial cells . Positive_regulation MAPK12 EPHB2 12386816 999762 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 [MAPK] and a biphasic *activation* of . Positive_regulation MAPK12 EPHB2 12403788 1036177 SB203580 , a p38 [MAPK] *inhibitor* , and PD98059 , an inhibitor , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation MAPK12 EPHB2 12486127 1056307 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain *had* little effect on basal Erk [MAPK] activation . Positive_regulation MAPK12 EPHB2 12511425 1070736 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation MAPK12 EPHB2 12801927 1120231 GE2 stimulation *induced* phosphorylation , whereas it did not alter the phosphorylation of c-Jun N-terminal kinase or p38 [MAPK] . Positive_regulation MAPK12 EPHB2 12832293 1105576 Exposure to E. coli DNA resulted in phosphorylation of ERK 1/2 [MAPK] and inhibitors of activity ( PD98059 , UO126 ) significantly *reduced* the evoked IL-8 production . Positive_regulation MAPK12 EPHB2 12878192 1115518 ( 2 ) the *activation* of JNK and p38 [MAPK] but not in embryonic fibroblasts ( MEFs ) derived from ASK1 knockout mice ( ASK1 ( -/- ) MEFs ) was depressed compared to MEFs derived from wild type mice ( ASK1 ( +/+ ) MEFs ) ; Positive_regulation MAPK12 EPHB2 14973553 1212585 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen activated protein kinase (MAPK)] signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation MAPK12 EPHB2 14998726 1216729 Furthermore , we found that PD98059 , an pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation MAPK12 EPHB2 15659876 1350305 The anabolic effect of TNF-alpha was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an . Positive_regulation MAPK12 EPHB2 16038626 1437411 SF significantly prevented Abeta induced increases in IL-1beta and p38 [MAPK] *activation* and also Abeta induced changes in and phospho-Akt/PKB expression levels . Positive_regulation MAPK12 EPHB2 17056059 1649526 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Positive_regulation MAPK12 EPHB2 17403539 1735933 Trauma-hemorrhage increased the production of IL-6 , IL-10 , IL-12 and TNF-alpha enhanced the expression of TLR4 , MyD88 as well as the *activation* of [MAPK] proteins ( p38 , and JNK ) in epidermal keratinocytes . Positive_regulation MAPK12 EPHB2 17416211 1777871 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK12 EPHB2 17464174 1731744 The mRNA and surface protein up-regulation of CCR1 and CCR2 in 9CRA stimulated cells were weakly blocked by the pretreatment of SB202190 , a p38 [MAPK] *inhibitor* , and PD98059 , an upstream inhibitor . Positive_regulation MAPK12 EPHB2 18164124 1869609 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 [MAPK] , but not by the *activation* of JNK , , and NF-kappaB pathway . Positive_regulation MAPK12 EPHB2 18266967 2000297 VEGF induced activation of p42 also *led* to the nuclear translocation of [MAPK/ERK1/2] . Positive_regulation MAPK12 EPHB2 18285354 1885405 Pre-treatment with the [MAPK] *inhibitors* SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( inhibitor ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation MAPK12 EPHB2 18338254 1938057 Interestingly , inhibition of by U0126 completely *prevented* artepillin C-induced p38 [MAPK] phosphorylation of PC12m3 cells . Positive_regulation MAPK12 EPHB2 18520049 1918672 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of , rather than by the *activation* of p38 [MAPK] , in the spinal cord . Positive_regulation MAPK12 EPHB2 18982426 2105746 These inhibitory effects were partially inhibited by SB203580 , a specific *inhibitor* of p38 [MAPK] , but not by PD98059 , a specific inhibitors of extracellular signal regulated kinase ( ) , and SP600125 , a specific inhibitor of c-Jun-N-terminal kinase (JNK) . Positive_regulation MAPK12 EPHB2 19189219 2113961 Moreover , EM1 treatment resulted in less activation of p38 [MAPK] and more *activation* of signaling in lipopolysaccharide stimulated DCs . Positive_regulation MAPK12 EPHB2 19276187 2051417 Treatment of cells with sphingosine induced suppression of and *activation* of p38 [MAPK] . Positive_regulation MAPK12 EPHB2 19429670 2106920 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either inhibitor , [p38MAPK] *inhibitor* or NF-kappaB inhibitor . Positive_regulation MAPK12 EPHB2 19522739 2103140 Treatment with [MAPK] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation MAPK12 EPHB2 19672126 2168065 A scratch wound assay of healing rates in SV40 immortalized human corneal epithelial cell line ( HCEC ) evaluated the relative contributions by p38 and and JNK [MAPK] signaling *activation* to wound healing . Positive_regulation MAPK12 EPHB2 20025124 2175512 Prior treatment of the cells with PD98059 , an kinase inhibitor or SB203580 , a [p38MAPK] *inhibitor* , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation MAPK12 EPHB2 20554538 2327621 The HNE enhanced Sp1 and NF-?B activities were attenuated by SB203580 , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , and PD98059 , an extracellular signal regulated kinase ( ) inhibitor , respectively . Positive_regulation MAPK12 EPHB2 21126656 2355798 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 [mitogen activated protein kinase] , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by . Positive_regulation MAPK12 EPHB2 21311676 2360033 Treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation MAPK12 EPHB2 21488184 2417972 Dexmedetomidine induced phosphorylation of JNK and p38 [MAPK] in rat aortic SMCs , but did not *induce* phosphorylation of . Positive_regulation MAPK12 EPHB2 21586573 2449665 Incubation of T cells with ESAT-6 induced phosphorylation and increased functional p38 [MAPK] activity , but not *activation* of or JNK . Positive_regulation MAPK12 EPHB2 21599960 2445724 In the present studies , induction of central sensitization as indicated by spinal dorsal horn [MAPK] *activation* , specifically and p38 phosphorylation , was assessed in the MIA-OA model . Positive_regulation MAPK12 EPHB2 23394443 2713234 When compared to hamsters bearing tumors that remained on the control diet , the buccal pouches of hamsters bearing tumors receiving turmeric showed the following results : ( 1 ) decreased cell proliferation ( diminished PCNA , cyclin D1 , and Bcl-2 ) and PCNA labelling index , ( 2 ) enhanced apoptosis ( increased Bax , caspase-3 , caspase-9 , and cytochrome c , and decreased survivin ) and apoptotic index , ( 3 ) decreased inflammation ( decreased Cox-2 ) , and ( 4 ) decreased [MAPK] *activation* ( and p-p38 ) . Positive_regulation MAPK12 EPHB2 23892041 2830334 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three [MAPK] *inhibitors* ( inhibitor PD98059 , JNK inhibitor SP600125 and p38 inhibitor SB203580 ) . Positive_regulation MAPK12 EPHB2 23914844 2840570 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 [MAPK] and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of , JNK , NF-?B . Positive_regulation MAPK12 EPHB2 23917355 2826023 Inhibition of Akt or activity *reduced* phosphorylation of STAT1 in Colon26L5-CUG2 cells whereas inhibition of p38 [MAPK] did not significantly decrease levels of STAT1 phosphorylation , indicating that cell proliferation signals may be involved in CUG2 mediated activation of STAT1 . Positive_regulation MAPK12 EPHB2 24225419 2897494 Therefore , by using the [MAPK] *inhibitors* SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific inhibitor ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation MAPK12 EPHB2 24297112 2894217 Following treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation MAPK12 F2R 16052512 1460024 The p38 and ERK1/2 [MAPK] signaling cascades were also *activated* by stimulation , whereas the SAPK/JNK pathway was unaffected . Positive_regulation MAPK12 F2R 16467309 1548151 and PAR-2 stimulation rapidly *activated* both ERK1/2 and [p38MAPK] , and pharmacological blockade of MEK with either PD98059 or U0126 or of p38MAPK by SB203580 or SB202190 strongly inhibited thrombin- and SLIGKV induced COX-2 expression and 6-keto-PGF1alpha formation . Positive_regulation MAPK12 F2R 21252088 2402884 In the present study , we show that FVIIa , upon binding to EPCR on endothelial cells , activates endogenous protease activated receptor-1 (PAR1) and induces mediated p44/42 [mitogen activated protein kinase (MAPK)] *activation* . Positive_regulation MAPK12 F2R 24052258 2867015 However , the distinct non-canonical tethered ligands unmasked by neutrophil elastase and proteinase-3 , as well as synthetic peptides with sequences derived from these novel exposed tethered ligands , selectively stimulated mediated [mitogen activated protein kinase] *activation* . Positive_regulation MAPK12 F2R 8635212 357888 These results support the notion that the *activates* [MAPK] through PKC dependent pathways and that the incremental activation of MAPK by TRAP over that induced by thrombin is the consequence of enhanced activation through the PKC limb of the phosphoinositide lipid pathway . Positive_regulation MAPK12 FAS 14576831 1156604 A more physiological inhibitor , the intracellular PP2A inhibitor protein I2 ( PP2A ) , protected transfected HeLa cells in a similar way from *mediated* apoptosis and induced activation of [MAPK] in I2 ( PP2A ) transfected cells . Positive_regulation MAPK12 FAS 15280387 1302531 We further demonstrate that this pro-apoptotic effect of CO was independent of reactive oxygen species production and involved inhibition in *induced* activation of the pro-survival ERK [MAPK] . Positive_regulation MAPK12 FAS 16507991 1529633 Here we show that binding of Fas ligand to *activates* p38 [MAPK] in CD8+ T cells and that activation of this pathway is required for Fas mediated CD8+ T-cell death . Positive_regulation MAPK12 FAS 19417161 2179809 GST-MDA-7 killing was , in parallel , dependent on inactivation of extracellular signal regulated kinase 1/2 and on *induced* p38 [mitogen activated protein kinase] and c-jun NH ( 2 ) -terminal kinase-1/2 signaling . Positive_regulation MAPK12 FAS 21613257 2454275 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Positive_regulation MAPK12 FAS 21975294 2492842 Caspase-8 activity has an essential role in mediated [MAPK] *activation* . Positive_regulation MAPK12 FAS 8977313 403345 IFN-alpha2 did not alter the *induced* activity of [Mitogen activated protein kinase (MAPK)] 1 and did not inhibit the Apo-1/Fas mediated proteolytic cleavage of ADP-ribosyltransferase , a substrate of Interleukin-beta1 converting enzyme ( ICE ) and homologues . Positive_regulation MAPK12 FHL1 23456229 2781816 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Positive_regulation MAPK12 FOXA1 22879989 2641681 An increase in IGFBP-3 , mediated by depletion of , *inhibited* phosphorylation of [MAPK] and Akt , and increased expression of the cell cycle regulators p21 and p27 . Positive_regulation MAPK12 FUT4 20506505 2307954 These data suggested that not only *activates* [MAPK] and PI3K/Akt signals , but also promotes the crosstalk among these signaling pathways . Positive_regulation MAPK12 GLP1R 21356521 2394814 activation by Exendin-4 ( Ex-4 ) *increased* PKA and [MAPK] activity and decreased phosphorylation of AMPK in NTS . Positive_regulation MAPK12 GPR115 10958680 725330 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK12 GPR115 11916960 945082 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK12 GPR115 9182581 435276 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK12 GPR115 9826186 549673 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK12 GPR132 10958680 725319 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK12 GPR132 11474113 841737 Activation of by LPC *increased* intracellular calcium concentration , induced receptor internalization , activated ERK [mitogen activated protein kinase] , and modified migratory responses of Jurkat T lymphocytes . Positive_regulation MAPK12 GPR132 11916960 945071 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK12 GPR132 9182581 435265 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK12 GPR132 9826186 549662 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK12 GPR87 10958680 725399 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK12 GPR87 11916960 945151 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK12 GPR87 9182581 435345 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK12 GPR87 9826186 549742 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK12 HBEGF 10544013 563922 also rapidly *activated* [MAPK] and induced cyclin D1 in mid-G1 with kinetics similar to TGFalpha . Positive_regulation MAPK12 HBEGF 11171084 783793 Both p42 [MAPK] activation and mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation MAPK12 HBEGF 15380451 1298479 *induced* phosphorylation of ERK , p38 [MAPK] and Akt , which were suppressed by ZD1839 . Positive_regulation MAPK12 HBEGF 17928891 1858623 We report that cellular stress with methyl-beta-cyclodextrin ( MBCD ) , a molecule that extracts membrane cholesterol and thereby disrupts the structure of lipid rafts , strongly *induces* the synthesis of ( HB-EGF ) in keratinocytes through the activation of p38 [mitogen activated protein kinase] . Positive_regulation MAPK12 HBEGF 18990151 2028922 *Activation* of [Erk/MAPK] by was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation MAPK12 HBEGF 19048624 2023715 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked MAPK signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 [MAPK] , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Positive_regulation MAPK12 HBEGF 19559571 2110503 *induced* phosphorylation of p42/p44 [MAPK] in a few minutes . Positive_regulation MAPK12 HBEGF 20739666 2345888 Moreover , *induced* a stronger and more sustained activation of both the [mitogen activated protein kinase] and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation MAPK12 HBEGF 24188029 2921100 Here , we show that *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , [Mapk/Erk] pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation MAPK12 HRH1 11959800 931440 1. Previous studies have shown that the *activates* p42/p44 [mitogen activated protein kinases (MAPK)] in DDT ( 1 ) MF-2 smooth muscle cells via a phosphatidylinositol 3-kinase (PI-3K) dependent pathway . Positive_regulation MAPK12 HRH1 17965772 1820338 is *required* for TCR mediated p38 [MAPK] activation and optimal IFN-gamma production in mice . Positive_regulation MAPK12 HRH1 17965772 1820352 Moreover , signaling at the time of TCR ligation was *required* for activation of p38 [MAPK] , a known regulator of IFN-gamma expression . Positive_regulation MAPK12 IFI27 16953232 1682575 RET2A mediated regulation of p18 and , but not of cyclins D1 and D2 , *requires* functional [mitogen activated protein kinase] signaling . Positive_regulation MAPK12 IL1B 10640438 577502 and TNF alpha also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK12 IL1B 10704772 673004 CPI-1189 inhibits *induced* [p38-mitogen activated protein kinase] phosphorylation : an explanation for its neuroprotective properties ? Positive_regulation MAPK12 IL1B 10775561 686643 *activated* p44/42 [MAPK] , and this activation was enhanced in the presence of N-acetyl-L-cysteine . Positive_regulation MAPK12 IL1B 10864897 705724 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK12 IL1B 10864897 705776 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by TNF-alpha and . Positive_regulation MAPK12 IL1B 10864897 705797 TNF-alpha- and *induced* [ ( 3 ) H ] -thymidine incorporation and phosphorylation of p42/p44 [MAPK] was completely inhibited by PD98059 ( an inhibitor of MEK1/2 ) , indicating that activation of MEK1/2 was required for these responses . Positive_regulation MAPK12 IL1B 10969830 728485 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Positive_regulation MAPK12 IL1B 11032891 740453 *induces* p38 [MAPK] phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation MAPK12 IL1B 11037878 741240 also *stimulated* phosphorylation of p38 [MAPK] , SAPK/JNK , and ATF-2 . Positive_regulation MAPK12 IL1B 11126408 759772 TNFalpha and IFNgamma potentiate *induced* [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK12 IL1B 11126408 759785 [Mitogen activated protein kinase (MAPK)] activity that is *induced* by has been suggested to signal nitric oxide dependent as well as nitric oxide independent beta-cell destructive pathways . Positive_regulation MAPK12 IL1B 11126408 759798 The aim of this study was to investigate if TNFalpha and IFNgamma signal through mitogen activated protein kinases in isolated rat islets of Langerhans and if they potentiate [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK12 IL1B 11126408 759811 Further , TNFalpha and IFNgamma were found to synergistically increase [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK12 IL1B 11399523 824259 Glucose potentiates *induced* p38 [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK12 IL1B 11509550 848359 Although and TNF-alpha each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK12 IL1B 11557585 861402 *activated* the three [mitogen activated protein kinase] ( extracellular signal regulated kinases 1 and 2 , c-Jun NH2-terminal kinase/stress activated protein kinase , and p38 ) and the Janus kinase (JAK)-signal transducer and activator of transcription pathways . Positive_regulation MAPK12 IL1B 11698472 878051 *induced* phosphorylation and activation of p38 [MAPK] and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation MAPK12 IL1B 11698472 878097 *induced* phosphorylation of ERK and JNK as well as p38 [MAPK] in human endothelial cells . Positive_regulation MAPK12 IL1B 11728947 884808 We showed a dramatic decrease in *induced* phosphorylation of p38 [MAPK] , not extracellular signal regulated kinases 1/2 or jun NH2-terminal kinase , in rat cultured mesangial cells by FR167653 . Positive_regulation MAPK12 IL1B 11775830 766436 Role of protein tyrosine kinase in *induced* activation of [mitogen activated protein kinase] in fibroblast-like synoviocytes of rheumatoid arthritis . Positive_regulation MAPK12 IL1B 11853544 913370 Interestingly , *induced* p38 [MAPK] activity was greatly enhanced in ( alg+ ) compared with ( alg- ) cells . Positive_regulation MAPK12 IL1B 12117921 964664 mRNA expression by neutrophils was not dependent on p38 MAPK , and p38 [MAPK] was not *activated* in neutrophils incubated with A. phagocytophila . Positive_regulation MAPK12 IL1B 12131776 966857 and TNF-alpha *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK12 IL1B 12139924 969395 Regarding intracellular signaling , *activated* the p38 mitogen activated protein kinase (MAPK) but not the p42/p44 [MAPK] and , when combined with growth factors , intensified p38 activation but inhibited the growth-factor induced p42/p44 activation . Positive_regulation MAPK12 IL1B 12356282 993842 induced p44/42 [mitogen activated protein kinase (MAPK)] *activation* was inhibited by the MAPK/extracellular signal regulated protein kinase ( MEK ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK12 IL1B 12417253 1012952 Sphondin ( 50 microM ) did not affect the *induced* activations of p44/42 [MAPK] , p38 MAPK , and JNK . Positive_regulation MAPK12 IL1B 12500176 1026686 These data suggest that the presence of retinal holes and may *lead* to activation of HGF , [mitogen activated protein kinases (MAPK)] , c-jun and extracellular matrix remodeling , resulting in proliferative and migratory cells in the wounded retina . Positive_regulation MAPK12 IL1B 12507586 1038420 In this study we evaluated the role of epigallocatechin-3-gallate ( EGCG ) , a green tea polyphenol which mimics its anti-inflammatory effects , in modulating the *induced* activation of [MAPK] 's in human chondrocytes . Positive_regulation MAPK12 IL1B 12649265 1080066 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant MKK6 or p38beta2 MAPK inhibited *induced* p38 [MAPK] activation , COX-2 gene expression , and PGE2 release . Positive_regulation MAPK12 IL1B 12727980 1086556 P38 [MAPK] phosphorylation was *increased* by in nondecidualized ESC , whereas the IL-1 beta induced increase was suppressed in the decidualized cells . Positive_regulation MAPK12 IL1B 12727980 1086569 Treatment with 8-bromo-cAMP reduced *induced* phosphorylation of p38 [MAPK] in nondecidualized ESC . Positive_regulation MAPK12 IL1B 12727980 1086583 In contrast , treatment with H89 , a protein kinase A inhibitor , reversed a reduction in *induced* p38 [MAPK] phosphorylation in the decidualized cells . Positive_regulation MAPK12 IL1B 12727980 1086597 The altered property of decidualized cells is thought to be caused by attenuation of *induced* p38 [MAPK] phosphorylation in a way that involves the activation of the cAMP/protein kinase A pathway . Positive_regulation MAPK12 IL1B 12882449 1116288 NAC ( 1 mM ) also decreased the *induced* activation of p38 [MAPK] . Positive_regulation MAPK12 IL1B 12952251 1137416 Using Western-blot analysis , no effect of cAMP was found on the *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK12 IL1B 12952251 1137430 No decrease was observed in *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK12 IL1B 14563491 1154859 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Positive_regulation MAPK12 IL1B 15039421 1251233 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of , and RIP2 dependent *activation* of NF-kappaB and p38 [MAPK] mediated by the caspase recruitment domain . Positive_regulation MAPK12 IL1B 15111866 1241238 We further demonstrated that p38 [MAPK] is *activated* by and PDGF with different kinetics and that p38 MAPK is required for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation MAPK12 IL1B 15208668 1281342 *induced* the activation of extracellular signal regulated kinases-1/2 and P38 [mitogen activated protein kinase (MAPK)] , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation MAPK12 IL1B 15341531 1291760 In accordance with these findings , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) , which was attenuated by U0126 , SB202190 , or SP600125 , respectively . Positive_regulation MAPK12 IL1B 15389584 1354318 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] and JNK which was attenuated by pretreatment with U0126 or SP600125 , respectively . Positive_regulation MAPK12 IL1B 15489374 1359422 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and JNK was attenuated by pretreatment with U0126 , SB-202190 , or SP-600125 , respectively . Positive_regulation MAPK12 IL1B 15755725 1403420 The inhibitory effect of on alpha ENaC expression was *mediated* by the activation of p38 [MAPK] in both rat and human ATII cells and was independent of the activation of alpha v beta6 integrin and transforming growth factor-beta . Positive_regulation MAPK12 IL1B 16033422 1436164 Intrathecal *leads* to a time dependent up-regulation of phosphorylated p38 ( p-p38 ) [MAPK] protein expression in the spinal cord 30-240 min following IL-1beta injection ( i.t. ) . Positive_regulation MAPK12 IL1B 16033422 1436178 However , pretreatment with a p38 MAPK inhibitor significantly reduced the *induced* p-p38 [MAPK] expression by 38-49 % , and nearly completely blocked the subsequent iNOS expression ( reduction by 86.6 % ) , NO production , and thermal hyperalgesia . Positive_regulation MAPK12 IL1B 16043966 1459740 Western blot analysis demonstrated that *increased* the activation of phosphorylated MEK and p38 [MAPK] in GH3 cells . Positive_regulation MAPK12 IL1B 16140882 1450804 *induced* phosphorylation of [p38-MAPK] , but not that of c-Jun-N-terminal kinase or extracellular regulated kinase , was most susceptible to inhibition by low doses of PFE , and the addition of PFE blocked the activity of p38-MAPK in a kinase activity assay . Positive_regulation MAPK12 IL1B 16141635 1454868 DHA stimulated both rapid and prolonged activation of p44/42 , but not p38 , [mitogen activated protein kinase (MAPK)] *induced* by and PMA . Positive_regulation MAPK12 IL1B 16153910 1455435 The kidney was analyzed for expression of tumor necrosis factor alpha , , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 [mitogen activated protein kinase] , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation MAPK12 IL1B 16452991 1611735 Western blots showed that and TNF-alpha *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK12 IL1B 16528573 1549427 The aim of this study was to investigate if Gadd45b prevents *induced* beta cell [MAPK] signalling and apoptosis . Positive_regulation MAPK12 IL1B 16645161 1604676 significantly *increased* the phosphorylation of p38 [MAPK] and cPLA(2) . Positive_regulation MAPK12 IL1B 16698013 1575653 JST ( 0.01-1 mg/ml ) also attenuated the expression of cyclooxygenase (COX)-2 and activation of p38 [MAPK] *induced* by and A beta ( 1-42 ) . Positive_regulation MAPK12 IL1B 16718462 1584908 A synthetic peptide , C3d , reported to bind NCAM , did not activate MAPK or Akt as reported in neurons but inhibited *induced* [MAPK] activity , thereby mimicking the effect of SU5402 . Positive_regulation MAPK12 IL1B 16718462 1584933 We suggest that NCAM signalling through FGFR is required for efficient IL-1beta pro-apoptotic signalling by facilitating *induced* [MAPK] activation downstream of the NF-kappaB-MAPK branching point . Positive_regulation MAPK12 IL1B 16718462 1584966 Further , these data identify a novel function of C3d as an inhibitor of NCAM induced FGFR activity and of *induced* [MAPK] activation in beta cells . Positive_regulation MAPK12 IL1B 16959849 1639697 *caused* an increase in the phosphorylation of ERK , but not [p38MAPK] or c-Jun N-terminal kinase . Positive_regulation MAPK12 IL1B 16964394 1611553 Inhibitors of p38 [MAPK] and/or JNK significantly suppressed VEGF secretion both in the *presence* and absence of , while inhibitors of COX-2 , ERK1/2 , and PI3-K did not . Positive_regulation MAPK12 IL1B 17208222 1695812 Thalidomide also suppressed induced p38 [mitogen activated protein kinase (MAPK)] *activation* , while a p38 MAPK inhibitor destabilized COX-2 mRNA and the cytoplasmic shuttling of HuR induced by IL-1beta . Positive_regulation MAPK12 IL1B 17311279 1719289 *stimulated* phosphorylation of p42/p44 [MAPK] , p38 MAPK , and JNK was attenuated by pretreatment with U0126 , SB202190 , SP600125 , or transfection with these dominant negative mutants of MEK , ERK , p38 and JNK , respectively . Positive_regulation MAPK12 IL1B 17390080 1716132 We have previously demonstrated that *induced* HBD-2 mRNA expression in A549 cells through activation of nuclear factor-kappaB (NF-kappaB) transcriptional factor as well as p38 [mitogen activated protein kinase (MAPK)] , c-Jun N-terminal kinase (JNK) , or phosphatidylinositol-3-kinase (PI3K) . Positive_regulation MAPK12 IL1B 17390080 1716161 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Positive_regulation MAPK12 IL1B 17390080 1716191 Triptolide inhibited *induced* [MAPK] phosphatase-1 expression at the transcriptional level and resulted in sustained phosphorylation of JNK or p38 MAPK , explaining the little effect of triptolide on IL-1beta induced phosphorylation of these kinases . Positive_regulation MAPK12 IL1B 17438131 1742772 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by TNF-alpha and , but not by ansiomycin or sorbitol . Positive_regulation MAPK12 IL1B 17559635 1753261 also *activated* extracellular signal regulated kinase , p38 [MAPK] , and c-Jun N-terminal kinase . Positive_regulation MAPK12 IL1B 17645739 1793269 Interestingly , Dex attenuated *mediated* activation of p38 [MAPK] and JNK , but not of AKT . Positive_regulation MAPK12 IL1B 17694686 1782105 IL-1beta induced NO levels and thermal hyperalgesia in rats , likely via either inhibiting the mediated p38 [MAPK] *activation* and subsequent iNOS induction , or direct attenuation of the central iNOS activity , which therefore reduces the central sensitization of inflammatory pain . Positive_regulation MAPK12 IL1B 17920534 1804189 SA981 at a concentration of 100 microM partially inhibited *induced* phosphorylation of [p38MAPK] and Akt ( 12.0 % and 36.1 % inhibition of each total amount of phosphoprotein under IL-1beta coexistence condition , respectively ) . Positive_regulation MAPK12 IL1B 17925024 1835153 *stimulated* phosphorylation of c-jun amino-terminal kinase , p38 [MAPK] and extracellular signal regulated kinase-1/2 . Positive_regulation MAPK12 IL1B 18026701 1827820 Moreover , glucosamine suppressed the *induced* phosphorylation of p38 [MAPK] ( p < 0.05 at > 0.1 mM ) and the IL-1beta binding to its receptors ( p < 0.05 at 1 mM ) . Positive_regulation MAPK12 IL1B 18065201 1853662 *stimulated* activation of ERK1/2 and p38alpha [MAPK] mediates the transcriptional up-regulation of IL-6 , IL-8 and GRO-alpha in HeLa cells . Positive_regulation MAPK12 IL1B 18348730 1925314 The *activation* or inhibition of p38 [MAPK] by and/or SB203580 was analyzed by western blotting . Positive_regulation MAPK12 IL1B 18348730 1925327 *activated* the phosphorylation of p38 [MAPK] and this effect was abolished by SB203580 . Positive_regulation MAPK12 IL1B 18427719 1920722 Phosphorylated p38 ( Phos-p38 ) [mitogen activated protein kinase] was *stimulated* in SW-1353 cells by but not by HA alone . Positive_regulation MAPK12 IL1B 18556347 1965929 or leptin individually *induced* threonine/tyrosine phosphorylation of p38 [MAPK] , whereas only leptin induced tyrosine phosphorylation of JAK2 , suggesting that leptin may enhance hBD-2 production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with NF-kappaB , which is activated by IL-1beta . Positive_regulation MAPK12 IL1B 18667841 1948051 Furthermore , *induced* p38 [mitogen activated protein kinase (MAPK)] activation and upregulation of VEGF-C mRNA and protein in LLC cells was also suppressed by artemisinin or by the p38 MAPK inhibitor SB-203580 , suggesting that p38 MAPK could serve as a mediator of proinflammatory cytokine induced VEGF-C expression . Positive_regulation MAPK12 IL1B 19362079 2081458 *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 [mitogen activated protein (MAP) kinase] , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation MAPK12 IL1B 19522843 2136338 In chondrocytes , CS diminishes *induced* increases in p38 [mitogen activated protein kinase] ( p38MAPK ) and signal regulated kinase 1/2 ( Erk1/2 ) phosphorylation , and decreases nuclear factor-kappaB (NF-kappaB) nuclear translocation and as a consequence , reduces the formation of pro-inflammatory cytokines , IL-1beta and TNF-alpha , and pro-inflammatory enzymes , such as phospholipase A2 (PLA2) , cyclooxygenase 2 (COX-2) and nitric oxide synthase-2 (NOS-2) . Positive_regulation MAPK12 IL1B 19765281 2163522 Treatment with PIP-18 blocked *induced* p38 [MAPK] phosphorylation and resulted in attenuation of sPLA2-IIA and MMP mRNA transcription in RA SF cells . Positive_regulation MAPK12 IL1B 20060906 2218520 In the present study , we demonstrate that *caused* activation of p38 [mitogen activated protein kinase] and that the p38 inhibitor SB203580 significantly blocked the effect of IL-1beta on I ( NMDA-OUT ) in hippocampal CA1 neurons . Positive_regulation MAPK12 IL1B 20353947 2266465 In model 1 , a differentiation model , CLA *activation* of [MAPK] and induction of interleukin-8 (IL-8) , IL-6 , , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation MAPK12 IL1B 21659536 2455193 Distinct roles for Nod2 protein and autocrine in muramyl dipeptide *induced* [mitogen activated protein kinase] activation and cytokine secretion in human macrophages . Positive_regulation MAPK12 IL1B 24692548 2935244 At 1 h , this was responsible for the dexamethasone inhibition of *induced* [MAPK] activation and CXCL1 and CXCL2 mRNA expression , with a similar trend for CSF2 . Positive_regulation MAPK12 IL1B 9475519 486790 Of these , *activated* only [MAPK] . Positive_regulation MAPK12 IL1B 9475519 486803 In cultured rat astrocytes , *caused* activation of [MAPK] without inducing proliferation . Positive_regulation MAPK12 IL1B 9575890 502732 Our data also indicate that both insulin and IGF-I enhance *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation and SAPK activation . Positive_regulation MAPK12 IL1B 9582321 503935 Previously we reported that *induces* activation of JNK/SAPK and p38 [MAPK] with concomitant up-regulation of cyclooxygenase (Cox)-2 expression and prostaglandin E2 ( PGE2 ) synthesis . Positive_regulation MAPK12 IL1B 9614146 509328 By Western blotting with phosphospecific antibodies and by immunocomplex kinase assay , was shown to *activate* extracellular signal regulated kinase ( ERK ) 1/2 and p38 [mitogen activated protein kinase] ( p38 ) in islets and rat insulinoma cells . Positive_regulation MAPK12 IL1B 9786861 540913 We reported previously that rapidly *activates* the c-Jun NH2-terminal/stress activated protein kinases ( JNK/SAPK ) and p38 [mitogen activated protein kinase (MAPK)] and also induces Cox-2 expression and prostaglandin E2 ( PGE2 ) production . Positive_regulation MAPK12 IL1B 9786861 540959 Overexpression of the kinase-dead form of MKK3 or MKK6 demonstrated that either of these two mutant kinases inhibited *induced* p38 [MAPK] phosphorylation and Cox-2 expression but not JNK/SAPK phosphorylation and activation . Positive_regulation MAPK12 ITGB2 12600815 1099060 IL-3 , IL-5 , and GM-CSF could enhance p38 [MAPK] and NF-kappaB activity and *induce* ICAM-1 , CD11b , and expressions on eosinophils . Positive_regulation MAPK12 ITGB2 19843511 2203200 Furthermore , beta2 integrins modulated the capacity of isolated peritoneal macrophages to take up acetylated LDL and native LDL and to phagocytose apoptotic cells , possibly via *dependent* [mitogen activated protein kinase] signalling . Positive_regulation MAPK12 LBP 20615568 2309936 Despite activating NFkappaB , NOD1 ligand did not upregulate hepatocyte production of the acute phase proteins lipopolysaccharide binding protein , serum amyloid A , or soluble CD14 in cell culture supernatants , or upregulate mRNA expression of , serum amyloid A , C-reactive protein , or serum amyloid P . NOD2 ligand ( MDP ) did not *activate* hepatocytes when given alone , but did synergize with Toll-like receptor ligands , lipopolysaccharide (LPS) , and polyI : C to activate NFkappaB and [MAPK] . Positive_regulation MAPK12 MAP2K6 10050043 592933 In one set of experiments , we *inhibited* the activation of [MAPK] by pretreating cells with PD098059 , a specific inhibitor of ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAPK12 MAP2K6 10079106 595479 Although MKK3 , MKK4 , and all *activated* p38 [MAPk] in experimental models , only MKK3 was found to activate recombinant p38 MAPk in LPS treated neutrophils . Positive_regulation MAPK12 MAP2K6 10471331 641612 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Positive_regulation MAPK12 MAP2K6 10601295 574413 In addition , *activation* of p38 [MAPK] by constitutively active or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAPK12 MAP2K6 10713051 674380 Conversely , the inhibitors PD98059 and UO126 could *attenuate* EGF induced [mitogen activated protein kinase] activation , they do not affect the EGF induced mobility shift of caveolin-1 . Positive_regulation MAPK12 MAP2K6 10759527 683152 These results demonstrate that a plant can phosphorylate and *activate* [MAPK] , and that Tyr phosphorylation is critical for the catalytic activity of MAPK in plants . Positive_regulation MAPK12 MAP2K6 10816593 714746 The MAPK kinase selectively *stimulates* p38 [MAPK] and confers protection against stress induced apoptosis in cardiac myocytes . Positive_regulation MAPK12 MAP2K6 10891559 711196 MAP kinases (MAPK) in both G-1 and G-5 cells were indistinguishably phosphorylated , yet dependent [MAPK] *activation* was observed only in G-5 cells . Positive_regulation MAPK12 MAP2K6 11005808 752423 A inhibitor , PD98059 , *inhibited* heat shock ERK [MAPK] activation by > 75 % . Positive_regulation MAPK12 MAP2K6 11085935 750727 Similarly , *activation* of JNK by Ad-MKK7D and [p38-MAPK] by resulted in the increased expression of PGHS-2 . Positive_regulation MAPK12 MAP2K6 11237743 790308 The MAPK kinase ( ) inhibitor , PD98059 , *blocked* GSA stimulated [MAPK] activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Positive_regulation MAPK12 MAP2K6 11304531 826830 The *activation* of p38 [MAPK] by Galpha ( q ) and Gbetagamma was blocked by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Positive_regulation MAPK12 MAP2K6 11787422 891930 Indeed the MAPK kinase ( = ) inhibitor PD98059 *inhibits* the activation of parasite [MAPK] , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Positive_regulation MAPK12 MAP2K6 11822870 909058 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of [MAPK] pathway *inhibitors* ( inhibitors PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAPK12 MAP2K6 12009309 940816 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Positive_regulation MAPK12 MAP2K6 12203369 983222 Furthermore , PKC inhibitors or an inhibitor completely *suppressed* both TPA induced activation of [MAPK] and promotion of anchorage independent growth , but a cPKC-selective inhibitor partially suppressed TPA induced promotion of the growth . Positive_regulation MAPK12 MAP2K6 12356282 993848 IL-1beta induced p44/42 [mitogen activated protein kinase (MAPK)] activation was *inhibited* by the MAPK/extracellular signal regulated protein kinase ( ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK12 MAP2K6 12377770 1019986 These results suggest that MKK3 , rather than , *mediates* alphav integrin induced p38 [MAPK] activation . Positive_regulation MAPK12 MAP2K6 12450322 1018640 ANG II significantly increased aldosterone release , and this effect was inhibited by the LO inhibitor baicalein , as well as a specific p38 [MAPK] *inhibitor* , SB202190 , but not by PD098059 , a specific inhibitor of the ERK activator . Positive_regulation MAPK12 MAP2K6 12637559 1085476 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Positive_regulation MAPK12 MAP2K6 12659851 1073512 MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a ( MAP2K ) , which in turn *activates* a [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK12 MAP2K6 12845643 1108592 Finally , both ODQ and UO126 blocked the capacity of L-arginine to restore ERK ( 1/2 ) phosphorylation in L-NAME treated cells , demonstrating that GC and are both *required* for endogenous NO-mediated [MAPK] activation . Positive_regulation MAPK12 MAP2K6 15104236 1240307 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( ) inhibitor , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAPK12 MAP2K6 15172888 1288384 Importantly , the presence of inhibitors only at the time of the transport assay markedly *impaired* both insulin stimulated glucose uptake and [MAPK] signaling . Positive_regulation MAPK12 MAP2K6 15172888 1288483 Conversely , removal of inhibitors before the transport assay *restored* glucose uptake and [MAPK] signaling . Positive_regulation MAPK12 MAP2K6 15304546 1322510 Furthermore , *activation* of [ERK/MAPK] by the coexpression of constitutively active predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAPK12 MAP2K6 15365248 1294568 Treatment of keratinocytes with PD98059 , inhibitor , and SB20358 , p38 [MAPK] *inhibitor* , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAPK12 MAP2K6 15570612 1355564 Although the inhibitors *suppressed* [MAPK] phosphorylation in both OA- and AICAR treated oocytes , meiotic resumption was not causally linked to MAPK phosphorylation in either group . Positive_regulation MAPK12 MAP2K6 15867183 1404242 In cultured cardiac myocytes , specific *activation* of stress activated [mitogen activated protein kinase] , p38 , by upstream activator led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAPK12 MAP2K6 15879307 1411357 Conversely , constitutively active *induced* p38 [MAPK] activation that recapitulated the effects of polyphenols by inducing ERalpha phosphorylation and downstream activation of Akt , and eNOS . Positive_regulation MAPK12 MAP2K6 16157033 1455760 SB203580 , a [P38MAPK] *inhibitor* , and U0126 , a inhibitor , both completely blocked ADM mediated responses in MsC . Positive_regulation MAPK12 MAP2K6 17416211 1777877 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK12 MAP2K6 18401006 1925825 CyaA enhanced LPS induced phosphorylation of p38 [MAPK] and ERK in DC , and inhibitors of p38 MAPK , , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation MAPK12 MAP2K6 18754769 1968436 ( MKK) 3 and 6 are the main p38 [mitogen activated protein kinase] *activators* in mammals . Positive_regulation MAPK12 MAP2K6 18771907 1962681 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a inhibitor , and SB203580 , an *inhibitor* of p38 [mitogen activated protein (MAP) kinase] , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAPK12 MAP2K6 21892182 2491662 Further , we show that *activation* of p38 [MAPK] by expression of constitutively active ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAPK12 MAP2K6 22164285 2517910 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of and marked *activation* of p38 [MAPK] . Positive_regulation MAPK12 MAP2K6 22785235 2691894 TRH induced CRE promoter was inhibited by [mitogen activated protein kinase/ERK] kinase ( MEK ) inhibitor and was *increased* by overexpression of . Positive_regulation MAPK12 MAP2K6 7644477 318665 Inhibition of by PD 098059 *prevented* activation of [MAPK] and subsequent phosphorylation of MAPK substrates both in vitro and in intact cells . Positive_regulation MAPK12 MAP2K6 7822248 285598 ( MKK ) phosphorylates and *activates* [mitogen activated protein kinase (MAPK)] in response to stimulation of various eukaryotic signaling pathways . Positive_regulation MAPK12 MAP2K6 7889302 289442 2. Both nucleotides stimulate phosphorylation and *activation* of [mitogen activated protein kinase] and a biphasic phosphorylation of the up-stream . Positive_regulation MAPK12 MAP2K6 8180183 256242 This stimulation of the activator was temporally *followed* by increased activities of MEK and [MAPK] . Positive_regulation MAPK12 MAP2K6 8226933 235413 *Activation* of extracellular signal regulated kinase ( ERK ) or [mitogen activated protein kinase] by ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAPK12 MAP2K6 8394352 228243 We show that a similar activity phosphorylates and *activates* [MAPK] in both growth factor stimulated ( epidermal growth factor and thrombin ) and oncogene ( gip2 , v-src , and v-raf ) -transfected cells . Positive_regulation MAPK12 MAP2K6 8550616 346670 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Positive_regulation MAPK12 MAP2K6 8663100 368160 The [MAPK] and NHE activities induced by PMA were *inhibited* by staurosporine , a potent inhibitor for protein kinase C ( PKC ) , and by MAPK kinase ( ) inhibitor , PD98059 , but were not affected by the tyrosine kinase inhibitor genistein . Positive_regulation MAPK12 MAP2K6 8663100 368255 In contrast , both AVP induced [MAPK] and NHE activities were *inhibited* by genistein and inhibitor but were not affected by staurosporine . Positive_regulation MAPK12 MAP2K6 8816498 384297 *activates* [mitogen activated protein kinase (MAPK)] , which phosphorylates other kinases as well as transcription factors . Positive_regulation MAPK12 MAP2K6 9029150 413632 SAPK3 and SAPK2 were activated at similar rates in vitro by ( also termed MKK6 ) , and SAPKK3 was the only *activator* of [SAPK3] that was induced when KB or 293 cells were exposed to cellular stresses or stimulated with IL-1 or TNF . Positive_regulation MAPK12 MAP2K6 9029150 413633 These experiments indicate that *mediates* the activation of [SAPK3] in several mammalian cells . Positive_regulation MAPK12 MAP2K6 9135064 427614 In addition to dependent [MAPK] *activation* , we provide evidence for MEK independent regulation of the MAPKs . Positive_regulation MAPK12 MAP2K6 9166761 432462 The first step in [MAPK] *activation* by must be the formation of a MEK x MAPK enzyme-substrate complex , followed by phosphorylation producing monophosphorylated MAPK ( pMAPK ) . Positive_regulation MAPK12 MAP2K6 9626658 511892 These results indicate that *mediates* the IGF-I/insulin induced p42/ p44 [MAPK] activation . Positive_regulation MAPK12 MAP2K6 9864179 582731 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of ERK , but not p38 [MAPK] , induced by G-CSF , GM-CSF , or TNF . Positive_regulation MAPK12 MMP7 16848631 1588319 and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 [mitogen activated protein kinase] activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MAPK12 MMP7 21999204 2547384 Mesothelin enhances invasion of ovarian cancer by *inducing* through [MAPK/ERK] and JNK pathways . Positive_regulation MAPK12 MUC16 11481474 843849 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a [mitogen activated protein kinase] ( Erk 1/2 ) , and *activation* of transcription . Positive_regulation MAPK12 PECAM1 18029285 1866921 In contrast , expression of Delta15 in PECAM-1-/- bEND cells *had* minimal effects on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Positive_regulation MAPK12 PGC 22105890 2599541 Our studies also revealed that overexpression of in cardiomyocytes *inhibited* basal and T3-induced p38 [MAPK] phosphorylation . Positive_regulation MAPK12 PIGR 20450283 2257147 Induction of expression in HT-29 cells *required* NF-kappaB signaling but not [MAPK] signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation MAPK12 PLAT 19436314 2107038 cerebrospinal fluid and brain parenchymal ERK [MAPK] was elevated by H/I and this upregulation was *potentiated* by , but blunted by RBC-tPA . Positive_regulation MAPK12 PLAT 21037505 2499494 Red blood blocked c-Jun-N-terminal kinase but *potentiated* p38 [mitogen activated protein kinase] upregulation after photothrombotic injury . Positive_regulation MAPK12 PLAU 10766865 684604 surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha [mitogen activated protein kinase] activity . Positive_regulation MAPK12 PLAU 15031204 1257168 In HeLa cells the dominant negative form of JNK interferes with the p42/p44 [MAPK] *activation* of the . Positive_regulation MAPK12 PLAU 15874933 1405697 Activation of the [mitogen activated protein kinases (MAPK)] , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Positive_regulation MAPK12 PLAU 15874933 1405730 Although uPA induced phosphorylation of both ERK1/2 and p38 MAPK was blocked by Galphai inhibition , inhibition of PI3K and Ras decreased the *induced* phosphorylation of ERK1/2 but not p38 [MAPK] . Positive_regulation MAPK12 PLAU 18656457 1960563 Exogenous administered at 4 h post H/I further *stimulated* ERK [MAPK] phosphorylation , which was blocked by RAP . Positive_regulation MAPK12 PLAU 9660790 517498 The receptor *mediates* tyrosine phosphorylation of focal adhesion proteins and activation of [mitogen activated protein kinase] in cultured endothelial cells . Positive_regulation MAPK12 PLAU 9660790 517511 The *induced* activation of [MAPK] was completely inhibited by genistein , but not by 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo [ 3 , 4-d ] pyrimidine , a specific inhibitor of Src family kinases . Positive_regulation MAPK12 PODXL 17616675 1769272 expression also *led* to an increase in [mitogen activated protein kinase (MAPK)] and phosphatidylinositol 3-kinase (PI3K) activity . Positive_regulation MAPK12 PODXL 17616675 1769319 These findings suggest that leads to increased in vitro migration and invasion , increased MMP expression , and *increased* activation of [MAPK] and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MAPK12 PTGER2 19233324 2072058 Further , PGE ( 2 ) , EP2A and EP4A did not increase BMP2/4 mRNA levels in RC cells , and *induced* phosphorylation of p38 [MAPK] was not eliminated by Noggin . Positive_regulation MAPK12 SLC38A3 15331357 1288012 In contrast , *stimulated* [MAPK] activation was blocked by > 80 % by dominant negative Ras but not by dominant negative Rho and Cdc42 . Positive_regulation MAPK12 SNCAIP 12639553 1068702 In addition , [MAPK] was *activated* by through Edg-1 , Sph-1-P receptor . Positive_regulation MAPK12 SPHK1 18602364 1941502 As a result , inhibition of by SKI *blocked* phosphorylation of p38 [MAPK] , showing that SPHK activation by IL-18 is an upstream signal of p38 MAPK activation . Positive_regulation MAPK12 STK39 17237610 1690256 The phosphorylation of cytoplasmic p38 [MAPK] in Akata cells was *reduced* by the inhibitor , 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperazine ( H7 ) . Positive_regulation MAPK12 TLR7 16424221 1515555 MKP-1-deficient macrophages also show enhanced constitutive and *induced* activation of p38 [MAPK] . Positive_regulation MAPK12 TLR7 23979601 2850635 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Positive_regulation MAPK12 TLR7 24879442 2940986 GIT2 terminates *induced* NF-?B and [MAPK] signaling by recruiting the deubiquitinating enzyme Cylindromatosis to inhibit the ubiquitination of TRAF6 . Positive_regulation MAPK12 TNF 10504489 648981 Pretreatment with SB203580 ( 10 microM ) had no effect on basal or TNF-alpha stimulated phosphorylation of p38 MAPK but completely abolished *stimulated* p38 [MAPK] activity . Positive_regulation MAPK12 TNF 10521481 653111 The study presented here shows that autoregulation of gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 [mitogen activated protein (MAP) kinase] activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation MAPK12 TNF 10570180 568159 Furthermore , LPS , UV irradiation , and *caused* activation of p38 [MAPK] whereas IFN-gamma did not . Positive_regulation MAPK12 TNF 10601128 574200 alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation MAPK12 TNF 10640438 577501 IL-1 beta and also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK12 TNF 10669634 665806 In this study , we show that *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation MAPK12 TNF 10753884 682341 Moreover , *stimulated* both the NF-kappaB and [mitogen activated protein (MAP) kinase] ( extracellular signal regulated kinase , c-Jun NH ( 2 ) -terminal kinase , and p38 MAP kinase ) signaling pathways in astrocytes . Positive_regulation MAPK12 TNF 10783388 707848 dependent p38 [MAPK] *activation* was detected in both Mo7e and Hut-78 cells and was blocked by the p38 MAPK inhibitor , SB203580 . Positive_regulation MAPK12 TNF 10783388 707901 SB203580 did not affect TNF-alpha signaled nuclear translocation and DNA binding activity of NF-kappaB , and inhibition of NF-kappaB function did not affect *induced* p38 [MAPK] activation , indicating that these events are not dependent on each other . Positive_regulation MAPK12 TNF 10864897 705723 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK12 TNF 10864897 705775 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by and IL-1beta . Positive_regulation MAPK12 TNF 11095634 755298 rapidly *activated* [MAPK] and increased the extent of attachment , spreading and migration on fibronectin and collagen type I ( P < 0.01 ) but not on collagen type IV . Positive_regulation MAPK12 TNF 11108246 756727 *activates* extracellular regulated kinase-1/2 ( ERK1/2 ) and [p38MAPK] . Positive_regulation MAPK12 TNF 11108836 757038 In RAW264 cells which differentiate into osteoclast-like multinucleated cells by TNF treatment alone , activation of p38 [mitogen activated protein (MAP) kinase] *induced* by murine was comparable to and independent of the receptor activator of necrosis factor-kappaB ligand . Positive_regulation MAPK12 TNF 11156586 780614 1. We have previously shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce interleukin-8 (IL-8) by human pulmonary vascular endothelial cells . Positive_regulation MAPK12 TNF 11167962 783065 It has previously been shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce cytokine , including RANTES , that N-acetylcysteine (NAC) attenuates cytokine production by human bronchial epithelial cells ( BECs ) , and that sensitivity to TNFalpha is inversely correlated with cellular redox state . Positive_regulation MAPK12 TNF 11266661 797168 However , *caused* no activation of p42/p44 [MAPK] or cytosolic phospholipase A(2) activity . Positive_regulation MAPK12 TNF 11277995 798110 *activates* extracellular regulated kinases ( ERKs ) and p38 [mitogen activated protein kinase] ( p38MAPK ) , and inhibits the expression of uncoupling protein-1 (UCP-1) and adipocyte-specific genes in rat fetal brown adipocytes . Positive_regulation MAPK12 TNF 11319753 806838 SB 203580 , a selective inhibitor of p38 MAPK , inhibited IL-1 and *induced* p38 [MAPK] activity and IL-6 production ( IC ( 50 ) s 0.3 -- 0.5 microM ) in osteoblasts and chondrocytes . Positive_regulation MAPK12 TNF 11319753 806859 In addition , IL-1 and also *activated* p38 [MAPK] in fetal rat long bones and p38 MAPK inhibitors inhibited IL-1- and TNF stimulated bone resorption in vitro in a dose dependent manner ( IC ( 50 ) s 0.3 -- 1 microM ) . Positive_regulation MAPK12 TNF 11435466 832528 However , the cytotoxic responses to daunorubicin and exogenous ceramide remain unaltered , as do the induced p42/p44 [MAPK] *activation* and CD54 expression . Positive_regulation MAPK12 TNF 11438547 843393 *activated* p38 [MAPK] and p44/p42 MAPK in wild-type but not in p60 ( -/- ) , p80 ( -/- ) , or p60 ( -/- ) p80 ( -/- ) macrophages . Positive_regulation MAPK12 TNF 11494147 846172 In this study we demonstrate that *triggers* only modest proliferation , as well as p44/p42 [mitogen activated protein kinase (MAPK)] and NF-kappaB activation , in MM.1S multiple myeloma ( MM ) cells . Positive_regulation MAPK12 TNF 11495721 846390 Furthermore , overexpression of dominant negative mutants , H-Ras-15A and Raf-N4 , significantly suppressed p42/p44 [mitogen activated protein kinase (MAPK)] activation *induced* by and PDGF-BB and attenuated the effect of TNF-alpha on BK-induced IP response , indicating that Ras and Raf may be required for activation of these kinases . Positive_regulation MAPK12 TNF 11509550 848357 Although IL-1 beta and each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK12 TNF 11592111 869659 Lipopolysaccharide (LPS) treatment of a microglial cell line ( N9 ) *induced* a time dependent activation of both p38 [mitogen activated protein kinase] ( p38 MAPK ) and nuclear factor-kappaB (NFkappaB) , with consequent increases in interleukin-1alpha (IL-1alpha) , , and nitric oxide ( NO ) production . Positive_regulation MAPK12 TNF 11694522 896413 *activated* the three mammalian [MAPK] , p44/42 , JNK , and p38 , in a distinct time- and concentration dependent manner . Positive_regulation MAPK12 TNF 11694522 896439 In conclusion , although *activates* all three known [MAPK] in human preadipocytes , only p44/42 and JNK appear to be involved in the regulation of lipolysis . Positive_regulation MAPK12 TNF 11750919 898171 Biochemical and immunocytochemical analysis showed that *activated* p38 mitogen activated protein kinase ( p38MAPK ) and c-Jun N-terminal kinase (JNK) but not p42/p44 [MAPK] . Positive_regulation MAPK12 TNF 11820362 908738 *activated* p38 [MAPK] and stimulated IL-6 secretion by MG-63 cells , and pre-incubation of cells with the p38 MAPK inhibitor abrogated TNF-alpha dependent IL-6 secretion . Positive_regulation MAPK12 TNF 11820362 908767 Transfection of IL-6 full-length and 5-deletion gene promoter reporter constructs indicated that p38 [MAPK] *activation* by enhanced IL-6 gene expression , and that the p38 MAPK-responsive region resided in the proximal 260-bp segment . Positive_regulation MAPK12 TNF 11820362 908803 In conclusion , although p38 [MAPK] *activation* by stimulates IL-6 secretion by MG-63 cells , it has opposing effects on c/EBPbeta and NFkappaB activity . Positive_regulation MAPK12 TNF 11930247 927418 The p44/42 [MAPK] activity was significantly *enhanced* by and the TNF-alpha effect was opposed by rhIL-10 . Positive_regulation MAPK12 TNF 11930247 927431 It is suggested that rhIL-10 can inhibit *induced* VSMC proliferation and phosphorylation of p44/42 [MAPK] . Positive_regulation MAPK12 TNF 12095140 960564 significantly increased permeability and *induced* p38 and ERK [MAPK] activation compared with controls ( P < 0.05 ) . Positive_regulation MAPK12 TNF 12114204 963994 *increased* the phosphorylation of p38 [MAPK] within 15 min. Anisomycin , an activator of p38 MAPK , increased p38 MAPK phosphorylation and decreased SP-A mRNA levels in a dose dependent manner . Positive_regulation MAPK12 TNF 12130576 966578 Phosphorylation of p38 [MAPK] was *induced* by RANKL , IL-1 , , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation MAPK12 TNF 12131776 966856 IL-1 beta and *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK12 TNF 12297009 991037 In this study , we examined the anti-apoptotic role of p38 [MAPK] that is *activated* by in neuronal PC12 cells . Positive_regulation MAPK12 TNF 12297009 991050 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Positive_regulation MAPK12 TNF 12393915 1025433 This model probiotic also inhibits *activation* of the pro-apoptotic [p38/mitogen activated protein kinase] by , interleukin-1alpha , or gamma-interferon . Positive_regulation MAPK12 TNF 12511413 1079034 The treatment of RAW264 cells with TSA and NaB inhibited *induced* nuclear translocation of NF-kappa B and sRANKL induced activation of p38 [mitogen activated protein kinase (MAPK)] signals . Positive_regulation MAPK12 TNF 12631113 1067615 Additional experiments examining the role of cAMP on MC fractalkine expression showed that the incubation of MCs with TNF-alpha and either db-cAMP or forskolin attenuated TNF-alpha stimulated fractalkine mRNA and protein expression , preceded by attenuation of *activated* phosphorylation of p42/44 [MAPK] , and c-Jun , but not phosphorylation of PKCzeta/iota or nuclear translocation of NF-kappaB . Positive_regulation MAPK12 TNF 12637577 1099305 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and *requires* p38 [MAPK] activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation MAPK12 TNF 12665666 1030370 This study was undertaken to examine the relationship between induced cardiomyocyte apoptosis and *activation* of p38 [mitogen activated protein kinase (MAPK)] through oxidative stress . Positive_regulation MAPK12 TNF 12665666 1030383 Corresponding to the apoptotic effect , at 10 ng/mL *caused* rapid phosphorylation of p38 [MAPK] in wild-type cardiomyocytes . Positive_regulation MAPK12 TNF 12694807 1080909 *induced* the phosphorylation of p44/p42 [mitogen activated protein (MAP) kinase] and p38 MAP kinase . Positive_regulation MAPK12 TNF 12731668 1086845 On the other hand , GM-CSF- or *induced* phosphorylation of ERK and p38 [MAPK] was unaffected by these inhibitors at the concentrations effective for the inhibition of O2- release and adherence . Positive_regulation MAPK12 TNF 12829618 1113804 However , *induced* [p38-MAPK] phosphorylation was markedly diminished in mkk3-/- vs mkk3+/+ hearts ( percent basal , 127+/-23 versus 540+/-267 , respectively , P=0.04 ) , suggesting an MKK independent activation mechanism by ischemia . Positive_regulation MAPK12 TNF 12844496 1149728 Rho inhibition decreases *induced* endothelial [MAPK] activation and monolayer permeability . Positive_regulation MAPK12 TNF 12844496 1149741 Because GTP binding proteins have been implicated in MAPK activation , we now hypothesize that the GTP binding protein Rho is a mediator of *induced* [MAPK] activation and increased endothelial permeability . Positive_regulation MAPK12 TNF 12844496 1149755 C3 transferase attenuated *induced* [MAPK] activation and blocked TNF induced endothelial permeability . Positive_regulation MAPK12 TNF 12867430 1141986 Subsequently , mediated p38 [MAPK] *activation* induced sialidase activity and CD44-HA binding . Positive_regulation MAPK12 TNF 12867430 1142105 Taken together , our results suggest that induced p38 [MAPK] *activation* may regulate the induction of functionally active HA-binding form of CD44 by activating sialidase in LPS stimulated human monocytic cells . Positive_regulation MAPK12 TNF 12881424 1116130 Importantly , does not induce ROS accumulation or prolonged MAPK activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently *induces* prolonged [MAPK] activation and necrotic cell death Positive_regulation MAPK12 TNF 12893778 1121028 We show that MKK3 and MKK6are essential for *stimulated* p38 [MAPK] activation . Positive_regulation MAPK12 TNF 12960255 1158286 To investigate a potential interplay between *induced* activation of p38 [MAPK] and NF-kappaB , the p38 MAPK inhibitor SB203580 and a dominant negative p38 MAPK mutant were used . Positive_regulation MAPK12 TNF 14516792 1147202 [MAPK] pathway *activation* via was confirmed by marked AP-1 activation detected in EMSA . Positive_regulation MAPK12 TNF 14561851 1165104 In cultured human umbilical vein endothelial cells ( HUVECs ) , and lipopolysaccharide *increased* phosphorylation of p38 [MAPK] ( P-p38 MAPK ) and increased ICAM-1 expression . Positive_regulation MAPK12 TNF 14592823 1209463 Analyzing the individual contribution of PF-4 and its costimuli in the control of these functions at the signaling level , we demonstrate that *induced* activation of p38 [mitogen activated protein (MAP) kinase] ( but not extracellular regulated kinase [ Erk ] kinases ) acts as general and essential costimulatory signal in PF-4 dependent neutrophil exocytosis . Positive_regulation MAPK12 TNF 14632659 1170649 *activated* p38 [MAPK] in DCs only at an early time-point ( 15 min ) . Positive_regulation MAPK12 TNF 14654378 1176827 These findings suggest that the pre-ischemic *activation* of [p38-MAPK] by does not contribute to cardioprotection afforded by this agent . Positive_regulation MAPK12 TNF 15002040 1265078 Consistent with the abrogation of osteoclastogenic effect of DcR3 by TNFR-Fc , DcR3 treatment can *induce* osteoclastogenic cytokine release through ERK and p38 [MAPK] signaling pathways . Positive_regulation MAPK12 TNF 15139014 1246956 The increase in release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not [mitogen activated protein kinase (MAPK)] , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation MAPK12 TNF 15191888 1295238 Treatment of endothelial cells with SphK1 siRNA suppressed *induced* increase in MCP-1 mRNA levels , MCP-1 protein secretion , and activation of p38 [MAPK] . Positive_regulation MAPK12 TNF 15212763 1262314 Interestingly , Ad5NIK , but not , *induces* RelA S536 and p38 [mitogen activated protein kinase (MAPK)] phosphorylation in IKKgamma ( -/- ) cells . Positive_regulation MAPK12 TNF 15233873 1269389 A. semen also inhibited the expression of and the *activation* of [mitogen activated protein kinase] , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation MAPK12 TNF 15240695 1270281 TNF activates Syk protein tyrosine kinase leading to induced [MAPK] *activation* , NF-kappaB activation , and apoptosis . Positive_regulation MAPK12 TNF 15240695 1270301 TNF induced Syk activation was abolished by piceatannol ( Syk-selective inhibitor ) , which led to the suppression of *induced* activation of c- JNK , p38 [MAPK] , and p44/p42 MAPK . Positive_regulation MAPK12 TNF 15240695 1270317 Jurkat cells that did not express Syk ( JCaM1 , JCaM1/lck ) showed lack of *induced* Syk , JNK , p38 MAPK , and p44/p42 [MAPK] activation , as well as TNF induced IkappaBalpha phosphorylation , IkappaBalpha degradation , and NF-kappaB activation . Positive_regulation MAPK12 TNF 15240695 1270348 Overall , our results demonstrate that Syk activation plays an essential role in *induced* activation of JNK , p38 [MAPK] , p44/p42 MAPK , NF-kappaB , and apoptosis . Positive_regulation MAPK12 TNF 15240725 1270456 p38 [MAPK] was *activated* by and oxidants in nonadherent conditions i.e. , with 10 mM EDTA . Positive_regulation MAPK12 TNF 15240725 1270470 Finally , p38 [MAPK] *activation* by was blocked by diphenylene iodonium , an inhibitor of flavoprotein oxidoreductase , and by the free radical scavenger N-acetylcystein . Positive_regulation MAPK12 TNF 15265936 1275732 Besides NF-kappa B , celecoxib also suppressed *induced* JNK , p38 [MAPK] , and ERK activation . Positive_regulation MAPK12 TNF 15290420 1278549 Halothane or isoflurane augmented the LPS- and *induced* activation of p38 [MAPK] . Positive_regulation MAPK12 TNF 15304089 1284478 DNCB , NiSO ( 4 ) and *activated* p38 [mitogen activated protein kinases (MAPK)] and c-jun N-terminal kinase ( JNK ) . Positive_regulation MAPK12 TNF 15322069 1333420 We have also investigated the phosphorylation of p42/44 [MAPK] and *upregulation* of RhoA protein by . Positive_regulation MAPK12 TNF 15452110 1341991 In contrast , induced p42/p44 [MAPK] *activation* and CD54 expression remained unaltered . Positive_regulation MAPK12 TNF 15589482 1356211 In addition , luteolin inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , IkappaB degradation , and NF-kappaB activation . Positive_regulation MAPK12 TNF 15659876 1350304 The anabolic effect of was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an extracellular regulated kinases (ERK) . Positive_regulation MAPK12 TNF 15696169 1372158 Using TCPTP-deficient fibroblasts , we show here that TCPTP regulates *induced* [MAPK] but not NF-kappaB signaling . Positive_regulation MAPK12 TNF 15696169 1372200 These results link TCPTP and Src tyrosine kinases to the selective regulation of *induced* [MAPK] signaling and identify a previously unknown mechanism for modulating inflammatory responses mediated by TNF . Positive_regulation MAPK12 TNF 15703956 1497467 *Activation* of p38 [mitogen activated protein (MAP) kinase] and phosphatidylinositol 3-kinase (PI3K) by was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation MAPK12 TNF 15792609 1386793 By stimulation of in AM-1 cells , the phosphorylation of Akt ( Ser473 ) and p44/42 [mitogen activated protein kinase (MAPK)] ( Thr202/Tyr204 ) was markedly *increased* in TNFalpha concentration and time dependent manner . Positive_regulation MAPK12 TNF 15792609 1386806 Pretreatment with U0126 , mitogen activated extracellular regulated kinase ( MEK) 1/2 inhibitor , prior to TNFalpha stimulation , specifically inhibited *induced* phosphorylation of p44/42 [MAPK] ( Thr202/Tyr204 ) in AM-1 cells . Positive_regulation MAPK12 TNF 15792609 1386822 Meanwhile , pretreatment with LY294002 , phosphatidylinositol-3-OH kinase (PI3K) inhibitor , could inhibit both *induced* phosphorylation of Akt ( Ser473 ) and p44/42 [MAPK] ( Thr202/Tyr204 ) . Positive_regulation MAPK12 TNF 15823554 1393911 Furthermore , potently *activated* p38 [MAPK] , JNK , and NF-kappaB . Positive_regulation MAPK12 TNF 15837794 1432548 Expression of this protein inhibited *induced* activation of NFkappaB , JNK , and p38 [MAPK] and sensitized the cells to TNF induced apoptosis . Positive_regulation MAPK12 TNF 15845648 1425546 *induces* a more than tenfold increase in p38 [mitogen activated protein kinase (MAPK)] but not extracellular signal regulated kinase phosphorylation . Positive_regulation MAPK12 TNF 15870903 1405546 In addition , GA inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , I kappa B alpha degradation , and NF-kappa B activation . Positive_regulation MAPK12 TNF 16009485 1441401 Moreover , p44/42 [mitogen activated protein kinase] appears to partly *mediate* the negative effect of insulin but not on ATGL . Positive_regulation MAPK12 TNF 16023081 1441587 Ellagic acid inhibited IL-1beta- and induced *activation* of activator protein-1 and mitogen activated protein kinases ( extracellular signal regulated kinase , c-Jun N-terminal kinase and p38 [mitogen activated protein kinase] ) , but not of nuclear factor-kappaB . Positive_regulation MAPK12 TNF 16025396 1435610 *activated* the phosphorylation of p44/42 [MAPK] , p38 MAPK , SAPK/JNK and Akt in mesangial cells . Positive_regulation MAPK12 TNF 16025396 1435626 PGE1 inhibited the *induced* phosphorylation of SAPK/JNK and Akt , but not p44/42 [MAPK] and p38 MAPK . Positive_regulation MAPK12 TNF 16080915 1442766 Comparative gene array analysis of *induced* [MAPK] and NF-kappaB signaling pathways between retinal ganglion cells and glial cells . Positive_regulation MAPK12 TNF 16140562 1499252 These results suggested that TNFalpha induced both cell survival and apoptosis pathways in ameloblastoma and potential of TNFalpha in inducing apoptosis can be improved by inhibiting *induced* Akt and p44/42 [mitogen activated protein kinase (MAPK)] cell survival pathways . Positive_regulation MAPK12 TNF 16275991 1480298 Angiotensin II , , or epidermal growth factor *induced* [MAPK] phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation MAPK12 TNF 16291729 1526069 *Activation* of [MAPK] and Akt by anti-HER2/neu inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation MAPK12 TNF 16314440 1486998 treatment *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation in NPCs , and SB202190 , an inhibitor of p38 MAPK , blocked TNF-alpha induced chemokine production . Positive_regulation MAPK12 TNF 16325162 1511663 Furthermore , APE1/ref-1 overexpression inhibited the *induced* increase in intracellular superoxide and p38 [MAPK] phosphorylation . Positive_regulation MAPK12 TNF 16452991 1611734 Western blots showed that IL-1beta and *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK12 TNF 16517732 1530934 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of , but not IL-6 , *requires* the activity of p38 [MAPK] . Positive_regulation MAPK12 TNF 16573652 1556135 HA-mediated production *required* p38 [MAPK] , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation MAPK12 TNF 16682409 1584056 Further , the deletion of NQO1 abolished induced c-Jun N-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] *activation* . Positive_regulation MAPK12 TNF 16781693 1585614 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and and the *activation* of [MAPK] 's are potentially positive signals for IL-10 production . Positive_regulation MAPK12 TNF 16798728 1638533 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Positive_regulation MAPK12 TNF 16875982 1593561 *activates* [p38-MAPK] , a stress-responsive kinase implicated in contractile depression and cardiac injury . Positive_regulation MAPK12 TNF 16875982 1593575 Under conditions of constant coronary flow , the [p38-MAPK] activation and contractile depression *induced* by , though attenuated , remained sensitive to the absence of MKK3 or the presence of SB203580 . Positive_regulation MAPK12 TNF 16875982 1593589 *activates* [p38-MAPK] in the intact heart and in isolated cardiac myocytes through MKK3 . Positive_regulation MAPK12 TNF 16982923 1617361 Compared with wild-type cells , MIF-deficient cells were hyporesponsive to IL-1- and *induced* [MAPK] activity , AP-1 activity , and cellular proliferation , while NF-kappaB function was preserved . Positive_regulation MAPK12 TNF 17070777 1649830 Inhibition of Syk down-regulated *induced* p38 and p44/42 [MAPK] phosphorylation and nuclear translocation of p65 NF-kappaB . Positive_regulation MAPK12 TNF 17099067 1676199 Importantly , Dex is able to increase the expression of MKP-1 , which causes an inactivation of *induced* p38 [MAPK] and mediates inhibition of E-selectin expression . Positive_regulation MAPK12 TNF 17126899 1677672 Stimulation of ECs with *induced* rapid increases in the phosphorylation of their mitogen activated protein kinases ( MAPKs ) [ extracellular signal regulated kinase ( ERK ) , c-Jun-NH2-terminal kinase (JNK) , and p38 [MAPK] ] ; Positive_regulation MAPK12 TNF 17126905 1686545 Differential regulation of and GM-CSF *induced* activation of P38 [MAPK] in neutrophils and eosinophils . Positive_regulation MAPK12 TNF 17138860 1653545 The role of delta-PKC in mediated *activation* of [MAPK] is not known . Positive_regulation MAPK12 TNF 17138860 1653571 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 MAPK are involved in TNF antiapoptotic signaling and whether delta-PKC is a key regulator of [MAPK] *activation* by . Positive_regulation MAPK12 TNF 17138860 1653597 In human neutrophils , *activated* both p38 [MAPK] and ERK1/2 principally via TNFR-1 . Positive_regulation MAPK12 TNF 17158449 1694251 A green fluorescent protein fusion protein containing the last 100 residues of TAK1 ( TAK1-C100 ) abolished the interaction of endogenous TAB2/TAB3 with TAK1 , the phosphorylation of TAK1 , and prevented the activation of IKK and [MAPK] *induced* by IL-1 , , and RANKL . Positive_regulation MAPK12 TNF 17161959 1694537 Upon examination of the signaling components , we found that was a potent *activator* of p38 , p44/42 , p54/46 [MAPK] , and IkappaBalpha ( IkappaBalpha ) . Positive_regulation MAPK12 TNF 17172975 1679385 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the [MAPK] , and production of . Positive_regulation MAPK12 TNF 17172975 1679411 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the [MAPK] , and production of . Positive_regulation MAPK12 TNF 17189827 1680163 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Positive_regulation MAPK12 TNF 17202326 1680813 Augmented lipopolysaccharide induced production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK12 TNF 17202326 1680839 In this study , we show that augmented LPS induced production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK12 TNF 17218473 1732513 The RhoA inhibitor C3 exoenzyme and the ROCK inhibitor Y-27632 both attenuated induced [MAPK] *activation* and blocked AR expression in HIMEC . Positive_regulation MAPK12 TNF 17220297 1703052 TRAF2 and ASK1 play essential roles in *induced* [mitogen activated protein kinase] signaling . Positive_regulation MAPK12 TNF 17258890 1725450 The effects of and FasL on GrB expression were specifically *mediated* by [p38MAPK] ( Mitogen-activated-protein-kinase ) activation . Positive_regulation MAPK12 TNF 17425653 1748782 The percentage increases in IL-18 induced phosphorylation of extracellular signal regulated kinase ( ERK ) in Th cells of NDN and DN were significantly higher than controls ( P < 0.05 ) , while the percentage increase in *induced* phosphorylation of p38 [MAPK] in monocytes and IL-18 induced phosphorylation of p38 MAPK in Th cells and monocytes were significantly higher in NDN patients than controls . Positive_regulation MAPK12 TNF 17438131 1742771 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation MAPK12 TNF 17438336 1749074 FAK promoted *stimulated* [MAPK] activation needed for maximal IL-6 production . Positive_regulation MAPK12 TNF 17438336 1749093 Analysis of FAK ( -/- ) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity , Tyr-397 phosphorylation , and the Pro-712/713 proline-rich region of FAK were required for *stimulated* [MAPK] activation and IL-6 production . Positive_regulation MAPK12 TNF 17446186 1749509 *increased* p38 [MAPK] phosphorylation , potently stimulated IRS-1 serine phosphorylation , and blunted insulin stimulated IRS-1 tyrosine and Akt phosphorylation and eNOS activity . Positive_regulation MAPK12 TNF 17531219 1762169 On the other hand , aloe emodin did not affect induced *activation* of p38 [mitogen activated protein kinase] or generation of reactive oxygen species . Positive_regulation MAPK12 TNF 17607712 1798188 Although *induced* the activation of p38 [MAPK] , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation MAPK12 TNF 17725582 1801633 MAC inhibited *induced* p38 [mitogen activated protein kinase] activation and cell death in cultured Schwann cells . Positive_regulation MAPK12 TNF 17895408 1823964 IA did not interfere with *induced* activation of c-Jun N-terminal kinase (JNK) and p38 [mitogen activated protein kinase] . Positive_regulation MAPK12 TNF 17942934 1814213 Deletion of NQO2 also abolished *induced* c-Jun NH2-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] activation . Positive_regulation MAPK12 TNF 17994109 1851161 triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 [MAPK] , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation MAPK12 TNF 18039275 1828527 Further downstream in this axis of signalling , blockade *reduces* only acute bronchoconstriction , while [MAPK] inhibition abrogates completely endotoxin induced inflammation . Positive_regulation MAPK12 TNF 18060043 1853601 In cultures of Schwann cells , astrocytes , and microglia , sLRP-alpha inhibited *induced* activation of p38 MAPK and [ERK/MAPK] . Positive_regulation MAPK12 TNF 18061162 1861515 We demonstrate that *induced* proliferation of C4HD murine mammary tumor cells and of T47D cells through the activation of p42/p44 [MAPK] , JNK , PI3-K/Akt pathways and nuclear factor-kappa B (NF-kappa B) transcriptional activation . Positive_regulation MAPK12 TNF 18091748 1847366 *induced* phosphorylation of extracellular signal regulated kinase ( ERK ) and Akt , but not p38 [mitogen activated protein kinase (MAPK)] , was attenuated by nicardipine , cilnidipine , benidipine , efonidipine , and azelnidipine . Positive_regulation MAPK12 TNF 18227157 1884362 It was shown that these three proteins could ( i ) induce expression of and tissue factor and ( ii ) *induce* phosphorylation of p44/42 [mitogen activated protein kinases (MAPK)] and activation of early growth response factor 1 (Egr-1) . Positive_regulation MAPK12 TNF 18258304 1884795 However , over-expression of a dominant negative form of Rac strongly inhibited induced p42/44 [MAPK] kinase *activation* , but had little effect upon JNK and no effect upon p38 MAPK activity . Positive_regulation MAPK12 TNF 18287053 1872488 Here , we show that the murine CMV M45 protein binds to RIP1 and inhibits *induced* activation of NF-kappaB , p38 [MAPK] , and caspase independent cell death . Positive_regulation MAPK12 TNF 18287248 1896524 Flavopiridol suppresses induced *activation* of activator protein-1 , c-Jun N-terminal kinase , p38 mitogen activated protein kinase (MAPK) , p44/p42 [MAPK] , and Akt , inhibits expression of antiapoptotic gene products , and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells . Positive_regulation MAPK12 TNF 18314542 1931905 P < 0.05 ) , and MKP-1 up-regulation was temporally related to the inhibition of *induced* p38 [MAPK] phosphorylation . Positive_regulation MAPK12 TNF 18336852 1912239 *stimulated* phosphorylation of p42/p44 [MAPK] and JNK were attenuated by pretreatment with the inhibitors U0126 and SP600125 or transfection with dominant negative mutants of DeltaERK and DeltaJNK . Positive_regulation MAPK12 TNF 18364436 1912767 We , for the first time , demonstrate that binding of staphylococcal enterotoxin B to MHC-II results in activation of TNF-alpha converting enzyme , epidermal growth factor receptor , [p38MAPK] , and NF-kappaB *inducing* biphasic production . Positive_regulation MAPK12 TNF 18443205 1938525 Conversely , *induced* increases in insulin receptor substrate-1 serine phosphorylation ( Ser ( 312 ) ) , Jun NH ( 2 ) -terminal kinase phosphorylation , and extracellular signal related kinase-1/2 [mitogen activated protein kinase (MAPK)] phosphorylation were unaltered by siRNA mediated IKKbeta reduction . Positive_regulation MAPK12 TNF 18518937 1971919 Although Cot/Tpl2 was phosphorylated in IRI and in the cultured tubular epithelial cells (TEC) after stimulation with LPS and hydrogen peroxide , there were no significant differences in terms of production , neutrophil infiltration or [MAPK] *activation* between Cot/Tpl2 ( +/+ ) and Cot/Tpl2 ( -/- ) mice . Positive_regulation MAPK12 TNF 18636175 1937269 Furthermore , glucosamine inhibited the *induced* phosphorylation of [p38MAPK] and NF-kappaB p65 , and the nuclear translocation of NF-kappaB in the cells . Positive_regulation MAPK12 TNF 18653803 1960516 PMA stimulated nSMase2 translocation was independent of p38 MAPK , and neither PKC inhibitors nor small interfering RNA had significant effects on *stimulated* p38 [MAPK] activation , indicating that PKC-delta does not act through p38 MAPK in regulating nSMase2 . Positive_regulation MAPK12 TNF 18710428 2028200 As for the signalling pathway , stimulation *led* to the phosphorylation of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and translocation of nuclear factor kappaB (NF-kappaB) ( p65 ) into the nuclei . Positive_regulation MAPK12 TNF 18710428 2028221 These data suggest that interaction *leads* to the phosphorylation of Erk1/2 and [p38MAPK] and nuclear translocation of NF-kappaB , which is closely associated with the production and activation of MMP-9 in cultured CC cells of HuCTT-1 and CCKS-1 . Positive_regulation MAPK12 TNF 18768892 1957216 Consistently , Nod2-null macrophages tolerant to LPS and MDP showed enhanced production of and IL-6 as well as increased NF-kappaB and [MAPK] *activation* in response to the dipeptide KF1B , the Nod1 agonist . Positive_regulation MAPK12 TNF 18948845 2053239 Hypertonic saline did not alter *induced* p38 [mitogen activated protein kinase] phosphorylation or constitutive vascular endothelial growth factor expression , suggesting that the observed inhibition is not a generalized suppression of protein phosphorylation or cellular function . Positive_regulation MAPK12 TNF 19100731 2031220 at 30 ng/ml significantly *increased* phosphorylation of receptor tyrosine kinase ( 175 kDa ) and p42 [mitogen activated protein (MAP) kinase] . Positive_regulation MAPK12 TNF 19130554 2025299 Stimulation of HIMEC with *triggered* phosphorylation of the [MAPK] , and up-regulation of VCAM-1 , FKN and ICAM-1 . Positive_regulation MAPK12 TNF 19234337 2079509 Analysis of downstream signals showed that inhibition of NAD(P)H oxidase partially inhibited NF-kappaB activation but did not reduce CCL2 mRNA stability or prevent *induced* phosphorylation of [p38MAPK] . Positive_regulation MAPK12 TNF 19275968 2072843 *stimulated* the phosphorylation levels of p38 [MAPK] , JNK , ERK1/2 and Akt in vascular endothelial cells . Positive_regulation MAPK12 TNF 19289468 2073037 The requirement for MADD was highly specific for *induced* activation of [MAPK] but not the related JNK and p38 kinases . Positive_regulation MAPK12 TNF 19371952 2081761 Of note , the IFN-gamma plus *stimulated* activation of p38 [MAPK] was suppressed following incubation with forskolin or DBcAMP alone . Positive_regulation MAPK12 TNF 19410630 2089694 By transfection of TAK1 siRNA , *induced* phosphorylation of IkappaBalpha , JNK1/2 , and [p38MAPK] , as well as IL-6 or IL-8 expression , were repressed . Positive_regulation MAPK12 TNF 19427347 2106793 *induced* the phosphorylation of p38 [mitogen activated protein (MAP) kinase] , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation MAPK12 TNF 19429670 2106861 Ang II and clearly *enhanced* ERK and [p38MAPK] phosphorylation . Positive_regulation MAPK12 TNF 19563733 2122007 Finally , EZS inhibited *induced* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phosphorylation . Positive_regulation MAPK12 TNF 19648110 2138330 This correlates with reduced *stimulated* p38 [MAPK] phosphorylation . Positive_regulation MAPK12 TNF 19648110 2138345 Repression of *induced* p38 [MAPK] phosphorylation , NF-kappaB dependent transcription , and IL-8 expression by dexamethasone are sensitive to transcriptional or translational inhibitors . Positive_regulation MAPK12 TNF 19648110 2138416 Thus , MKP-1 attenuates *dependent* activation of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Positive_regulation MAPK12 TNF 19648110 2138443 Small interfering RNA knockdown of dexamethasone induced MKP-1 expression partially reverses the repression of *activated* p38 [MAPK] , demonstrating that MKP-1 participates in the dexamethasone dependent repression of this pathway . Positive_regulation MAPK12 TNF 19788916 2163921 Tumor necrosis factor ( ) and H ( 2 ) O ( 2 ) *activate* [mitogen activated protein kinase (MAPK)] in SH-SY5Y cells within 5 min and this activation is completely blocked by DLPC ( 12 microM ) . Positive_regulation MAPK12 TNF 19877072 2160710 CpdA also displayed profound effects on *induced* [MAPK] activation . Positive_regulation MAPK12 TNF 19877072 2160727 In sharp contrast , DEX did not affect induced IKK phosphorylation , IkappaBalpha degradation , p65 nuclear translocation , or [MAPK] *activation* in RA FLS . Positive_regulation MAPK12 TNF 19889458 2197302 Calpain inhibition induces random migration in TNF-alpha stimulated cells and prevents the generation of reactive oxygen species , but does not alter mediated *activation* of p38 [MAPK] and ERK MAPK . Positive_regulation MAPK12 TNF 20231691 2237857 TNF-alpha treatment resulted in the phosphorylation of p38 MAPK and its downstream target , MAPK activated protein kinase-2 , but IFN-gamma did not affect the levels of [MAPK] and MAPK activated protein kinase-2 phosphorylation *induced* by . Positive_regulation MAPK12 TNF 20489729 2327419 *induced* activation of p38 [MAPK] and the production of inducible nitric oxide synthase were suppressed in ASK1-deficient Müller glial cells . Positive_regulation MAPK12 TNF 20646342 2292548 Effects of budesonide on P38 [MAPK] activation , apoptosis and IL-8 secretion , *induced* by and Haemophilus influenzae in human bronchial epithelial cells . Positive_regulation MAPK12 TNF 20646342 2292576 induced a significant *increase* in p38 [MAPK] phosphorylation . Positive_regulation MAPK12 TNF 20693316 2351477 In four of the six donors , basal and *induced* ERK and p38 [MAPK] activation were higher in ASMA than ASMNA cells . Positive_regulation MAPK12 TNF 20696856 2351508 Surprisingly , replenishment with exogenous GSH normalizes both *dependent* NF-?B as well as [MAPK] signaling and rescues hepatocytes from FKB induced death . Positive_regulation MAPK12 TNF 20951126 2364953 Taken together , this study provided first evidence demonstrating that TRAIL- , , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK12 TNF 21123734 2377721 The ability of CO to inhibit *induced* ERK1/2 and p38 [MAPK] activities in an Akt dependent manner appears to be the key element in ROS dependent survival of endothelial cells during TNF-a mediated brain inflammatory disease . Positive_regulation MAPK12 TNF 21181166 2499607 IL-1ß and *activated* the intracellular mitogen activated protein kinases ( MAPKs ) : p44/42 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) as well as nuclear factor-?B ( NF-?B ) in osteoblasts . Positive_regulation MAPK12 TNF 21285293 2425722 Inhibitors of NADPH oxidase and/or p47phox siRNA diminished ROS production and COX-2 expression as well as phosphorylation of p38 [mitogen activated protein kinase] ( p38MAPK ) and Akt *mediated* either by AS serum or by . Positive_regulation MAPK12 TNF 21336587 2457988 Effects of preconditioning with sevoflurane on *induced* permeability and activation of p38 [MAPK] in rat pulmonary microvascular endothelial cells . Positive_regulation MAPK12 TNF 21422246 2416767 Interestingly , all PHA-L ( high ) DCs displayed a strongly reduced responsiveness to induced [p38-MAPK] *activation* compared with PHA-L ( low ) DCs , indicating differences in PHA-L binding capacities between DCs with different inflammatory properties . Positive_regulation MAPK12 TNF 21422246 2416781 Moreover , hybrid-type , but not complex-type , N-glycans are required for induced [p38-MAPK] *activation* and subsequent phenotypic maturation of BMDCs ( MHC-II , CD86 , CCR7 upregulation ) . Positive_regulation MAPK12 TNF 21520062 2423120 Here , we report that *induced* cPLA(2) protein and mRNA expression , PGE ( 2 ) production , and phosphorylation of p42/p44 MAPK , p38 [MAPK] , and JNK1/2 , which were attenuated by pretreatment with a ROS scavenger [ N-acetyl-L-cysteine , ( NAC ) ] and the inhibitors of NADPH oxidase [ apocynin (APO) and diphenyleneiodonium chloride ( DPI ) ] , MEK1/2 ( U0126 ) , p38 MAPK ( SB202190 ) , and JNK1/2 ( SP600125 ) or transfection with siRNA of Nox2 , p47(phox) , MEK1 , p42 , p38 , or JNK2 . Positive_regulation MAPK12 TNF 21545687 2554379 significantly *induced* phosphorylation of p38 [MAPK] , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation MAPK12 TNF 21894146 2510867 Vehicle and untreated NTN exhibited heavy proteinuria and glomerular thrombosis at 24 h with P-selectin and fibrin immunostaining within capillaries , glomerular macrophage and T cell infiltration , *activation* of JNK and p38 [MAPK] signalling , and upregulation of glomerular mRNA levels of pro-inflammatory molecules ( , NOS2 , MMP-12 and CCL2 ) . Positive_regulation MAPK12 TNF 22002864 2526326 These results suggest that H ( 2 ) O ( 2 ) -induced secretion of *increases* apoptosis of cardiac myocytes through ROS dependent activation of p38 [MAPK] . Positive_regulation MAPK12 TNF 22227193 2544575 Casuarinin significantly inhibited *induced* activation of NF-?B , STAT1 , and p38 [MAPK] . Positive_regulation MAPK12 TNF 22230399 2519475 KMUP-1 inhibited *induced* iNOS and U46619 induced PDE-5A and phospho-p38 [MAPK] in normoxia , confirming its anti-proinflammatory action . Positive_regulation MAPK12 TNF 22250084 2551210 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Positive_regulation MAPK12 TNF 22343222 2617811 Using immunohistological techniques , we showed a higher epithelial expression of , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator [protein-1/mitogen activated protein kinase] signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation MAPK12 TNF 22525504 2522571 *up-regulated* the phosphorylation levels of p38 [MAPK] and increased the translocation of NF-kB p65 protein into the nucleus , also proved by immunofluorescence staining . Positive_regulation MAPK12 TNF 22526394 2595912 also *increased* the production of inducible nitric oxide synthase (iNOS) , nitric oxide ( NO ) , and intercellular adhesion molecule 1 ( ICAM-1 ) through activation of p38 [mitogen activated protein kinase (MAPK)] from HT-29 cells . Positive_regulation MAPK12 TNF 22773691 2659901 *induced* activation of p38 [MAPK] and NF-?B was attenuated by miR-140-3p mimic . Positive_regulation MAPK12 TNF 22819264 2646094 CORM-2 inhibited *induced* activation of p38 [MAPK] , ERK1/2 , JNK , and NF-?B signaling pathways in HUVECs . Positive_regulation MAPK12 TNF 22947346 2678660 *induced* phosphorylated p38 [mitogen activated protein kinase] levels were increased in ASMCs from patients with severe asthma compared with those from patients with nonsevere asthma and nonasthmatic subjects , whereas TNF-a induced phosphorylated c-Jun N-terminal kinase and phosphorylated extracellular signal related kinase levels were increased in all asthmatic groups . Positive_regulation MAPK12 TNF 22988345 2674354 The EGF receptor and HER2 participate in *dependent* [MAPK] activation and IL-8 secretion in intestinal epithelial cells . Positive_regulation MAPK12 TNF 22988345 2674382 As the epidermal growth factor receptor (EGFR) is a known transducer of proliferative signals and a potent activator of MAPKs , we hypothesized that the EGFR participates in *dependent* [MAPK] activation and IL-8 secretion by intestinal epithelial cells ( IECs ) . Positive_regulation MAPK12 TNF 23071098 2720903 Mixed-effects modeling analysis of our data was vital for ascertaining that IL-1a and TGF-a treatment increased the activities of more pathways than IL-6 and TNF-a and that TGF-a and *increased* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phospho-protein levels in a synergistic manner . Positive_regulation MAPK12 TNF 23142559 2722785 Western blot analysis revealed that pilocarpine and physostigmine enhanced the *induced* phosphorylation of ERK1/2 and p38 [MAPK] and the degradation of I?Ba . Positive_regulation MAPK12 TNF 23333920 2758383 Interestingly , IL-27 promoted the basal and enhanced *induced* phosphorylation of p38 [MAPK] and Akt , but not I?Ba . Positive_regulation MAPK12 TNF 23353699 2754239 We further demonstrated that markedly *stimulated* p38 MAPK , p42/p44 [MAPK] , and JNK1/2 phosphorylation via a c-Src/EGFR , PDGFR/PI3K/Akt pathway . Positive_regulation MAPK12 TNF 23354775 2770415 p38a [mitogen activated protein kinases (MAPK)] may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , , interleukin-1ß , and oxidative stress . Positive_regulation MAPK12 TNF 23664593 2838382 sFGL2 secretion by CD4 ( + ) T cells can be *induced* with and IFN-? stimulation through [MAPK] signaling in renal allograft AR . Positive_regulation MAPK12 TNF 23861542 2817221 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Positive_regulation MAPK12 TNF 23884101 2821467 Furthermore , P. vulgaris extract suppressed *induced* phosphorylation of p38 [mitogen activated protein kinase (MAPK)] and extracellular signal regulated kinase ( ERK ) . Positive_regulation MAPK12 TNF 23935096 2840763 In contrast , loss of SK1 prevented *induced* phosphorylation of p38 [MAPK] , and inhibition of p38 MAPK , like SK1 knockdown , also potentiates RANTES induction . Positive_regulation MAPK12 TNF 24069158 2846992 We showed that markedly *stimulated* p42/p44 [MAPK] , p38 MAPK , and JNK1/2 phosphorylation which were attenuated by their respective inhibitors . Positive_regulation MAPK12 TNF 24080497 2902538 Consistently , DUSP1 promotes apoptosis and decreases NF-?B activity in cells in which p38 [MAPK] is *induced* by treatment . Positive_regulation MAPK12 TNF 24089494 2848149 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed receptor 1 and *requires* activation of p38 [MAPK] , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation MAPK12 TNF 24361597 2911244 We further demonstrated that *stimulated* ERK1/2 , p38 [MAPK] , and JNK1/2 phosphorylation via a c-Src dependent PDGFR/PI3K/Akt pathway . Positive_regulation MAPK12 TNF 24378531 2911772 TRAF2 has been previously reported to be required for *induced* activation of p38 [MAPK] . Positive_regulation MAPK12 TNF 24441870 2922932 We showed that markedly *stimulated* Jak2 , PDGFR , Akt , and p42/p44 [MAPK] phosphorylation , which were attenuated by their respective inhibitors . Positive_regulation MAPK12 TNF 24441870 2922950 In addition , *induced* p42/p44 [MAPK] phosphorylation was reduced by AG1296 or LY294002 . Positive_regulation MAPK12 TNF 24441870 2922986 On the other hand , could *induce* Akt and p42/p44 [MAPK] translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation MAPK12 TNF 24446489 2912937 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Positive_regulation MAPK12 TNF 24489443 2884791 Finally , by investigating the intracellular pathways involved in promoting the VEC release of cytokines/chemokines , which are targeted by natural anti-inflammatory compounds , we documented that aLipoic acid significantly counteracted *induced* NF-?B and [p38/MAPK] activation while the effects of Ginkgo biloba appeared to be predominantly mediated by Akt . Positive_regulation MAPK12 TNF 24750790 2936566 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas and NO production *required* all three [MAPK] . Positive_regulation MAPK12 TNF 7689564 225763 *induced* activation and increased tyrosine phosphorylation of [mitogen activated protein (MAP) kinase] in human fibroblasts . Positive_regulation MAPK12 TNF 7689564 225776 *induced* activation of [MAPK] was demonstrated by its enhanced ability to phosphorylate myelin basic protein in vitro and by a characteristic shift in the electrophoretic mobility of MAPK proteins . Positive_regulation MAPK12 TNF 7722327 301756 *induces* tyrosine phosphorylation of [mitogen activated protein kinase] in adherent human neutrophils . Positive_regulation MAPK12 TNF 7722327 301782 PMN pretreatment with genistein , a tyrosine kinase inhibitor , inhibited the *induced* increase in tyrosine phosphorylation and [MAPK] activity . Positive_regulation MAPK12 TNF 8626494 360275 Inhibition of induced p42/p44 [mitogen activated protein kinase] *activation* by sodium salicylate . Positive_regulation MAPK12 TNF 8626494 360289 *activates* both p42 and p44 [mitogen activated protein kinases (MAPK)] in human FS-4 fibroblasts , cells for which TNF is mitogenic . Positive_regulation MAPK12 TNF 8626494 360302 We now show that *activates* p42 [MAPK] in two cell lines whose growth is inhibited by TNF . Positive_regulation MAPK12 TNF 8626494 360317 We now show that neither phorbol ester-sensitive protein kinase C nor Gialpha link TNF to p42/p44 MAPK activation , because pretreatment of FS-4 cells with phorbol ester to down-regulate protein kinase C or pretreatment with pertussis toxin to block Gialpha does not inhibit p42/p44 [MAPK] *activation* by . Positive_regulation MAPK12 TNF 8626494 360338 To further analyze MAPK activation in FS-4 cells , we compared p42/p44 [MAPK] *activation* by and epidermal growth factor (EGF) . Positive_regulation MAPK12 TNF 8626494 360362 Elucidation of the mechanism whereby sodium salicylate blocks *induced* p42/p44 [MAPK] activation may help to clarify TNF activated signaling pathways . Positive_regulation MAPK12 TNF 8662702 367181 additionally *caused* rapid p38 and JNK-1 [mitogen activated protein kinase] activation and efficient NF-kappaB translocation , which could not be achieved even by high levels of ceramide . Positive_regulation MAPK12 TNF 9106254 424411 The increases in [MAPK] *induced* by and IL-1 were similar to the increases induced by PMA and PDGF-AB . Positive_regulation MAPK12 TNF 9106254 424437 Our findings indicate that and IL-1 activate parallel signal transduction pathways in human neuroma fibroblasts , and that they are relatively stronger *activators* of [MAPK] than of SAPK . Positive_regulation MAPK12 TNF 9315666 456099 , an inhibitor of insulin stimulated adipogenesis , *activated* [MAPK] in 3T3-L1 cells . Positive_regulation MAPK12 TNF 9439626 482868 *increased* ERK1 and ERK2 [MAPK] phosphorylation . Positive_regulation MAPK12 TNF 9439626 482894 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic effect of *requires* protein tyrosine phosphorylation and [MAPK] activation . Positive_regulation MAPK12 TNF 9593119 505484 The CAZ released endotoxin was similar to purified LPS with respect to the following biological activities in LPS-responsive C3H/HeN mice and LPS-hyporesponsive C3H/HeJ mice : lethal toxicity in GalN sensitized mice , in vitro induction of and NO production by macrophages , and [mitogen activated protein kinase] *activation* in macrophages . Positive_regulation MAPK12 TNF 9766635 538506 Our data suggest that and GM-CSF *activate* ERKs and p38 [MAPK] by different signal transduction pathways . Positive_regulation MAPK12 TNF 9770326 538801 Furthermore , *induction* of p42/p44 ERK and [p38-MAPK] phosphorylation , c-jun kinase activation , and IkappaBalpha degradation were normal . Positive_regulation MAPK12 TNF 9883899 558207 *Activation* of p42/p44 mitogen activated protein kinases (MAPK) and p38 [MAPK] by is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation MAPK12 TNF 9883899 558222 Here , we demonstrate that is *sufficient* to activate p42/p44 [MAPK] and p38 MAPK . Positive_regulation MAPK12 TNF 9930718 588836 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Positive_regulation MAPK12 TNF 9931102 588903 ( 100 U/mL ) transiently *activated* [MAPK] with a maximal induction 10 minutes after stimulation that returned to baseline levels by 2 hours after treatment . Positive_regulation MAPK12 TNF 9931102 588916 PD98059 also blocked *stimulated* [MAPK] activation in a concentration dependent manner , which is consistent with its inhibition of TNF-alpha directed migration . Positive_regulation MAPK12 TNF 9931102 588929 To identify which TNF-alpha receptor is involved in *induced* [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Positive_regulation MAPK12 TNF 9931102 588955 VSMC express both receptors , but induced [MAPK] *activation* was inhibited only by the TNF-R1 antibody . Positive_regulation MAPK12 TNF 9931102 588981 Both TRO and RSG inhibited migration , but neither attenuated *induced* [MAPK] activation , indicating that their antimigration activity was exerted downstream of MAPK . Positive_regulation MAPK12 TNFSF10 12969966 1185570 Among the intracellular pathways investigated , significantly *stimulated* the extracellular signal regulated kinase 1/2 ( ERK1/2 ) but not the [p38/mitogen activated protein kinase (MAPK)] or the c-Jun NH2-terminal kinase (JNK) pathway . Positive_regulation MAPK12 TNFSF10 20951126 2364954 Taken together , this study provided first evidence demonstrating that , TNF-a- , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK12 TNFSF10 21152872 2373392 Taken together , we show herein that the upstream molecule of the *induced* [MAPK] activation is MEKK , as opposed to ASK1 , via the mediation of its signal through JNK/p38 in a caspase-8 dependent manner . Positive_regulation MAPK13 ADRB2 11018034 752789 induced p38 [MAPK] *activation* is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes . Positive_regulation MAPK13 ADRB2 12509508 1038740 beta-Arrestin 1 is required for internalization and [mitogen activated protein (MAP) kinase] *activation* by the . Positive_regulation MAPK13 ADRB2 19047375 2023483 Hematopoietic protein tyrosine phosphatase mediates *induced* regulation of p38 [mitogen activated protein kinase] in B lymphocytes . Positive_regulation MAPK13 ADRB2 9038193 415364 In the present work , we report that stimulation of the A2A-adenosine receptor and of the *activates* [mitogen activated protein kinase] ( MAP kinase ) in human endothelial cells based on the following criteria : adenosine analogues and beta-adrenergic agonists cause an ( i ) increase in tyrosine phosphorylation of the p42 isoform and to a lesser extent of the p44 isoform of MAP kinase and ( ii ) stimulate the phosphorylation of myelin basic protein by MAP kinase; (iii) this is accompanied by a redistribution of the enzyme to the perinuclear region . Positive_regulation MAPK13 ADRB2 9363896 462907 We show that in HEK293 cells , *stimulation* of [mitogen activated protein (MAP) kinase] by the is mediated by the betagamma subunits of pertussis-toxin-sensitive G proteins through a pathway involving the non-receptor tyrosine kinase c-Src and the G protein Ras . Positive_regulation MAPK13 ALOX5 11807011 903507 In contrast , stress induced product formation and translocation of <5-LO> , as well as *activation* of p38 [MAPK] , occurred also after Ca ( ++ ) depletion . Positive_regulation MAPK13 ALOX5 21200133 2391686 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Positive_regulation MAPK13 ANGPT1 12039842 954280 Accordingly , ephrinB2 inhibited VEGF- and *induced* [Ras-MAPK] activities , whereas ephrinB2 did not alter VEGF induced Flk phosphorylation or Ang1 induced Tie2 phosphorylation . Positive_regulation MAPK13 ANGPT1 12213710 985641 Both VEGF and *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 [MAPK] . Positive_regulation MAPK13 ANGPT1 12213726 985711 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of and Ang-2 as well as the *activation* of [MAPK] , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation MAPK13 ANGPT1 16061664 1439068 *activated* [mitogen activated protein kinase (MAPK)] and phosphoinositide 3-kinase (PI3K) in IBE cells and HUVECs . Positive_regulation MAPK13 ANGPT1 16679392 1612152 Pretreatment with either DPI or apocynin also significantly attenuated *induced* Akt and p44/42 [MAPK] phosphorylation . Positive_regulation MAPK13 ANGPT1 16679392 1612168 Using mouse heart microvascular endothelial cells from wild-type ( WT ) mice and mice deficient in the p47(phox) component of NADPH oxidase ( p47 ( phox-/- ) ) , we found that although *stimulated* intracellular ROS , Akt and p42/44 [MAPK] phosphorylation , and cell migration in WT cells , the responses were strikingly suppressed in cells from the p47 ( phox-/- ) mice . Positive_regulation MAPK13 ANGPT1 20072135 2235286 *promoted* skin cell metabolism/viability , adhesion , and akt and [MAPK] ( p42/44 ) activations . Positive_regulation MAPK13 ANO1 22564524 2619161 *induces* [MAPK] and contributes directly to tumorigenesis and cancer progression . Positive_regulation MAPK13 CAPN8 21543591 2424103 Downstream , an Aß-mediated rise in p38 [mitogen activated protein kinase (MAPK)] activation was followed by downregulation of cAMP response element binding protein , and LTP impairment was *prevented* by inhibitors of p38 MAPK or . Positive_regulation MAPK13 CAPN8 24416390 2900971 Treatment with glutamate leads to early activation of NMDAR , which in turn leads to mediated cleavage of striatal enriched protein tyrosine phosphatase ( STEP ) and subsequent *activation* of p38 [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK13 CCL17 23711854 2792894 IL-33 induced the production of thymus and activation regulated and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 [MAPK] . Positive_regulation MAPK13 CCND1 11004713 735014 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping [ERK-MAPK] activation and c-Fos and *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation MAPK13 CCND1 12654183 1072983 [MAPK] may *induce* overexpression of protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation MAPK13 CCND1 15634644 1349553 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 [mitogen activated protein kinase] , and down-regulation of . Positive_regulation MAPK13 CCND1 16522728 1531457 We conclude that incretin induced beta-cell replication is dependent on cAMP/PKA , p42 [MAPK] and PI3K activities , which may *involve* transcriptional induction of . Positive_regulation MAPK13 CCND1 9537433 497558 Furthermore , in 25 of 26 cases of HCC which genomic DNA was available , 22 cases without genomic DNA amplification exhibited positive correlation , not only between protein expression of c-Fos and , but also between [MAPK/ERK] *activation* and cyclin D1 expression . Positive_regulation MAPK13 CD14 15625444 1349236 LPS interacts with the cell surface receptor , which generates transmembrane signals through Toll-like protein 4 *leading* to [mitogen activated protein kinase (MAPK)] p38 activation , cytokine synthesis , PMN beta2-integrin expression and oxidative burst . Positive_regulation MAPK13 CHI3L1 23755018 2797727 In addition , *induces* [FAK-MAPK] signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation MAPK13 CHI3L1 23972995 2836239 We also demonstrate that *activates* macrophage [mitogen activated protein kinase] , protein kinase B/AKT , and Wnt/ß-catenin signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation MAPK13 CLU 23051594 2702812 FOXL2 directly stimulates the Clu gene promoter , and we show that PTTG triggers ataxia telangiectasia mutated [kinase/IGF-I/p38MAPK] DNA damage/chromosomal instability signaling , which in turn also *induces* expression . Positive_regulation MAPK13 CTGF 11732999 885262 *induces* chondrocyte differentiation through a p38 [mitogen activated protein kinase] ( p38MAPK ) , and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase ( ERK ) . Positive_regulation MAPK13 CTGF 11732999 885276 In the proliferation phase , *induced* a approximately fivefold increase in the phosphorylation of p44/42 [MAPK/ERK] and a approximately twofold increase in that of p38 MAPK in an in vivo kinase assay . Positive_regulation MAPK13 CTGF 12218048 1012162 The inhibition of *induced* p42/44 [MAPK] or phosphatidylinositol 3-kinase (PI3K)/protein kinase B pathway activities abrogated the induction of fibronectin expression . Positive_regulation MAPK13 CTGF 16408113 1513477 *enhanced* the mRNA expression and protein release of fractalkine , MCP-1 , and RANTES , the expression of phospho ( P ) -p42/44 [mitogen activated protein kinase (MAPK)] , P-phosphoinositide 3-kinase (PI3-K) , P-Akt , and activity of nuclear factor-kappaB (NF-kappaB) in mesangial cells . Positive_regulation MAPK13 CTGF 16408113 1513505 P-p42/44 MAPK blockade inhibited the *induced* expression of P-p42/44 [MAPK] but not NF-kappaB , and partially decreased the levels of the above chemokines in supernatants . Positive_regulation MAPK13 CTGF 16522717 1531325 ( 3 ) *stimulated* dose dependent HSC adhesion and activity of p42/p44 [mitogen activated protein kinase] , the latter of which was antagonized by blocking the activity of focal adhesion kinase . Positive_regulation MAPK13 CTGF 16938382 1654124 No single module , but a mixture of the 4 modules provoked a significant activation of p38 [MAPK] in HCS-2/8 cells , which was *activated* by the full-length . Positive_regulation MAPK13 CTGF 19038999 2023083 Interestingly , CCN2-BMP-2 did not affect the *induced* phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Positive_regulation MAPK13 EDN2 12193071 980931 The molecular mechanisms of dependent *activation* of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Positive_regulation MAPK13 EDN2 12475899 1037769 *induced* a rapid phosphorylation of the [mitogen activated protein kinase (MAPK)/ERK] and increased collagen I gene activity in freshly isolated aortas . Positive_regulation MAPK13 EDN2 1280103 203036 rapidly *stimulates* [mitogen activated protein kinase] activity in rat mesangial cells . Positive_regulation MAPK13 EDN2 12855582 1149887 also *induced* the activation of p42/44 [mitogen activated protein kinase (MAPK)] in DCs . Positive_regulation MAPK13 EDN2 7509933 241603 *stimulates* [mitogen activated protein kinase] p42 activity through the phosphorylation of the kinase in rat mesangial cells . Positive_regulation MAPK13 EDN2 7849246 286727 *stimulates* [mitogen activated protein kinase] activity in mesangial cells through ETA . Positive_regulation MAPK13 EDN2 7943276 276394 has been shown to *activate* [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK13 EDN2 8836145 386168 In bovine airway smooth-muscle cells platelet derived growth factor ( PDGF ) and ( Et-1 ) *stimulate* sustained and comparable activation of [mitogen activated protein kinase] ( MAP kinase ) but display very different mitogenic efficacies , with PDGF inducing 50 times more DNA synthesis than Et-1 . Positive_regulation MAPK13 EFNB1 15502157 1347560 Further downstream of the signaling pathway , stimulation *led* to increased LAT ( linker for activation of T-cells ) phosphorylation and p44/42 and p38 [MAPK] activation . Positive_regulation MAPK13 EPHB2 10601128 574204 Tumor necrosis factor-alpha (TNF-alpha) alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only . Positive_regulation MAPK13 EPHB2 10872747 707025 Pre-treatment of the cells with PD98059 , a selective pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation MAPK13 EPHB2 11083274 750491 Tumor necrosis factor alpha , interleukin-1 (IL-1) , and IL-6 were the major inducers of , JNK , and p38 [MAPK] *activation* in cultured human synovial cells . Positive_regulation MAPK13 EPHB2 12386816 999763 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 [MAPK] and a biphasic *activation* of . Positive_regulation MAPK13 EPHB2 12403788 1036179 SB203580 , a p38 [MAPK] *inhibitor* , and PD98059 , an inhibitor , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation MAPK13 EPHB2 12486127 1056308 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain *had* little effect on basal Erk [MAPK] activation . Positive_regulation MAPK13 EPHB2 12511425 1070737 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation MAPK13 EPHB2 12801927 1120232 GE2 stimulation *induced* phosphorylation , whereas it did not alter the phosphorylation of c-Jun N-terminal kinase or p38 [MAPK] . Positive_regulation MAPK13 EPHB2 12832293 1105577 Exposure to E. coli DNA resulted in phosphorylation of ERK 1/2 [MAPK] and inhibitors of activity ( PD98059 , UO126 ) significantly *reduced* the evoked IL-8 production . Positive_regulation MAPK13 EPHB2 12878192 1115519 ( 2 ) the *activation* of JNK and p38 [MAPK] but not in embryonic fibroblasts ( MEFs ) derived from ASK1 knockout mice ( ASK1 ( -/- ) MEFs ) was depressed compared to MEFs derived from wild type mice ( ASK1 ( +/+ ) MEFs ) ; Positive_regulation MAPK13 EPHB2 14973553 1212612 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen activated protein kinase (MAPK)] signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation MAPK13 EPHB2 14998726 1216730 Furthermore , we found that PD98059 , an pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation MAPK13 EPHB2 15659876 1350307 The anabolic effect of TNF-alpha was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an . Positive_regulation MAPK13 EPHB2 16038626 1437415 SF significantly prevented Abeta induced increases in IL-1beta and p38 [MAPK] *activation* and also Abeta induced changes in and phospho-Akt/PKB expression levels . Positive_regulation MAPK13 EPHB2 17056059 1649527 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Positive_regulation MAPK13 EPHB2 17403539 1735934 Trauma-hemorrhage increased the production of IL-6 , IL-10 , IL-12 and TNF-alpha enhanced the expression of TLR4 , MyD88 as well as the *activation* of [MAPK] proteins ( p38 , and JNK ) in epidermal keratinocytes . Positive_regulation MAPK13 EPHB2 17416211 1777879 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK13 EPHB2 17464174 1731745 The mRNA and surface protein up-regulation of CCR1 and CCR2 in 9CRA stimulated cells were weakly blocked by the pretreatment of SB202190 , a p38 [MAPK] *inhibitor* , and PD98059 , an upstream inhibitor . Positive_regulation MAPK13 EPHB2 18164124 1869610 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 [MAPK] , but not by the *activation* of JNK , , and NF-kappaB pathway . Positive_regulation MAPK13 EPHB2 18266967 2000299 VEGF induced activation of p42 also *led* to the nuclear translocation of [MAPK/ERK1/2] . Positive_regulation MAPK13 EPHB2 18285354 1885406 Pre-treatment with the [MAPK] *inhibitors* SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( inhibitor ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation MAPK13 EPHB2 18338254 1938058 Interestingly , inhibition of by U0126 completely *prevented* artepillin C-induced p38 [MAPK] phosphorylation of PC12m3 cells . Positive_regulation MAPK13 EPHB2 18520049 1918673 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of , rather than by the *activation* of p38 [MAPK] , in the spinal cord . Positive_regulation MAPK13 EPHB2 18982426 2105747 These inhibitory effects were partially inhibited by SB203580 , a specific *inhibitor* of p38 [MAPK] , but not by PD98059 , a specific inhibitors of extracellular signal regulated kinase ( ) , and SP600125 , a specific inhibitor of c-Jun-N-terminal kinase (JNK) . Positive_regulation MAPK13 EPHB2 19189219 2113962 Moreover , EM1 treatment resulted in less activation of p38 [MAPK] and more *activation* of signaling in lipopolysaccharide stimulated DCs . Positive_regulation MAPK13 EPHB2 19276187 2051418 Treatment of cells with sphingosine induced suppression of and *activation* of p38 [MAPK] . Positive_regulation MAPK13 EPHB2 19429670 2106921 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either inhibitor , [p38MAPK] *inhibitor* or NF-kappaB inhibitor . Positive_regulation MAPK13 EPHB2 19522739 2103141 Treatment with [MAPK] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation MAPK13 EPHB2 19672126 2168067 A scratch wound assay of healing rates in SV40 immortalized human corneal epithelial cell line ( HCEC ) evaluated the relative contributions by p38 and and JNK [MAPK] signaling *activation* to wound healing . Positive_regulation MAPK13 EPHB2 20025124 2175513 Prior treatment of the cells with PD98059 , an kinase inhibitor or SB203580 , a [p38MAPK] *inhibitor* , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation MAPK13 EPHB2 20554538 2327622 The HNE enhanced Sp1 and NF-?B activities were attenuated by SB203580 , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , and PD98059 , an extracellular signal regulated kinase ( ) inhibitor , respectively . Positive_regulation MAPK13 EPHB2 21126656 2355799 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 [mitogen activated protein kinase] , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by . Positive_regulation MAPK13 EPHB2 21311676 2360034 Treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation MAPK13 EPHB2 21488184 2417973 Dexmedetomidine induced phosphorylation of JNK and p38 [MAPK] in rat aortic SMCs , but did not *induce* phosphorylation of . Positive_regulation MAPK13 EPHB2 21586573 2449666 Incubation of T cells with ESAT-6 induced phosphorylation and increased functional p38 [MAPK] activity , but not *activation* of or JNK . Positive_regulation MAPK13 EPHB2 21599960 2445726 In the present studies , induction of central sensitization as indicated by spinal dorsal horn [MAPK] *activation* , specifically and p38 phosphorylation , was assessed in the MIA-OA model . Positive_regulation MAPK13 EPHB2 23394443 2713236 When compared to hamsters bearing tumors that remained on the control diet , the buccal pouches of hamsters bearing tumors receiving turmeric showed the following results : ( 1 ) decreased cell proliferation ( diminished PCNA , cyclin D1 , and Bcl-2 ) and PCNA labelling index , ( 2 ) enhanced apoptosis ( increased Bax , caspase-3 , caspase-9 , and cytochrome c , and decreased survivin ) and apoptotic index , ( 3 ) decreased inflammation ( decreased Cox-2 ) , and ( 4 ) decreased [MAPK] *activation* ( and p-p38 ) . Positive_regulation MAPK13 EPHB2 23892041 2830335 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three [MAPK] *inhibitors* ( inhibitor PD98059 , JNK inhibitor SP600125 and p38 inhibitor SB203580 ) . Positive_regulation MAPK13 EPHB2 23914844 2840571 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 [MAPK] and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of , JNK , NF-?B . Positive_regulation MAPK13 EPHB2 23917355 2826027 Inhibition of Akt or activity *reduced* phosphorylation of STAT1 in Colon26L5-CUG2 cells whereas inhibition of p38 [MAPK] did not significantly decrease levels of STAT1 phosphorylation , indicating that cell proliferation signals may be involved in CUG2 mediated activation of STAT1 . Positive_regulation MAPK13 EPHB2 24225419 2897495 Therefore , by using the [MAPK] *inhibitors* SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific inhibitor ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation MAPK13 EPHB2 24297112 2894219 Following treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation MAPK13 F2R 16052512 1460025 The p38 and ERK1/2 [MAPK] signaling cascades were also *activated* by stimulation , whereas the SAPK/JNK pathway was unaffected . Positive_regulation MAPK13 F2R 16467309 1548153 and PAR-2 stimulation rapidly *activated* both ERK1/2 and [p38MAPK] , and pharmacological blockade of MEK with either PD98059 or U0126 or of p38MAPK by SB203580 or SB202190 strongly inhibited thrombin- and SLIGKV induced COX-2 expression and 6-keto-PGF1alpha formation . Positive_regulation MAPK13 F2R 21252088 2402885 In the present study , we show that FVIIa , upon binding to EPCR on endothelial cells , activates endogenous protease activated receptor-1 (PAR1) and induces mediated p44/42 [mitogen activated protein kinase (MAPK)] *activation* . Positive_regulation MAPK13 F2R 24052258 2867016 However , the distinct non-canonical tethered ligands unmasked by neutrophil elastase and proteinase-3 , as well as synthetic peptides with sequences derived from these novel exposed tethered ligands , selectively stimulated mediated [mitogen activated protein kinase] *activation* . Positive_regulation MAPK13 F2R 8635212 357905 These results support the notion that the *activates* [MAPK] through PKC dependent pathways and that the incremental activation of MAPK by TRAP over that induced by thrombin is the consequence of enhanced activation through the PKC limb of the phosphoinositide lipid pathway . Positive_regulation MAPK13 FAS 14576831 1156605 A more physiological inhibitor , the intracellular PP2A inhibitor protein I2 ( PP2A ) , protected transfected HeLa cells in a similar way from mediated apoptosis and induced *activation* of [MAPK] in I2 ( PP2A ) transfected cells . Positive_regulation MAPK13 FAS 15280387 1302532 We further demonstrate that this pro-apoptotic effect of CO was independent of reactive oxygen species production and involved inhibition in induced *activation* of the pro-survival ERK [MAPK] . Positive_regulation MAPK13 FAS 16507991 1529635 Here we show that binding of Fas ligand to *activates* p38 [MAPK] in CD8+ T cells and that activation of this pathway is required for Fas mediated CD8+ T-cell death . Positive_regulation MAPK13 FAS 19417161 2179810 GST-MDA-7 killing was , in parallel , dependent on inactivation of extracellular signal regulated kinase 1/2 and on *induced* p38 [mitogen activated protein kinase] and c-jun NH ( 2 ) -terminal kinase-1/2 signaling . Positive_regulation MAPK13 FAS 21613257 2454276 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Positive_regulation MAPK13 FAS 21975294 2492843 Caspase-8 activity has an essential role in mediated [MAPK] *activation* . Positive_regulation MAPK13 FAS 8977313 403346 IFN-alpha2 did not alter the *induced* activity of [Mitogen activated protein kinase (MAPK)] 1 and did not inhibit the Apo-1/Fas mediated proteolytic cleavage of ADP-ribosyltransferase , a substrate of Interleukin-beta1 converting enzyme ( ICE ) and homologues . Positive_regulation MAPK13 FHL1 23456229 2781817 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Positive_regulation MAPK13 FOXA1 22879989 2641682 An increase in IGFBP-3 , mediated by depletion of , *inhibited* phosphorylation of [MAPK] and Akt , and increased expression of the cell cycle regulators p21 and p27 . Positive_regulation MAPK13 FUT4 20506505 2307955 These data suggested that not only *activates* [MAPK] and PI3K/Akt signals , but also promotes the crosstalk among these signaling pathways . Positive_regulation MAPK13 GLP1R 21356521 2394815 activation by Exendin-4 ( Ex-4 ) *increased* PKA and [MAPK] activity and decreased phosphorylation of AMPK in NTS . Positive_regulation MAPK13 GPR115 10958680 725423 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK13 GPR115 11916960 945175 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK13 GPR115 9182581 435369 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK13 GPR115 9826186 549766 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK13 GPR132 10958680 725412 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK13 GPR132 11474113 841738 Activation of by LPC *increased* intracellular calcium concentration , induced receptor internalization , activated ERK [mitogen activated protein kinase] , and modified migratory responses of Jurkat T lymphocytes . Positive_regulation MAPK13 GPR132 11916960 945164 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK13 GPR132 9182581 435358 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK13 GPR132 9826186 549755 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK13 GPR87 10958680 725492 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK13 GPR87 11916960 945244 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK13 GPR87 9182581 435438 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK13 GPR87 9826186 549835 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK13 HBEGF 10544013 563923 also rapidly *activated* [MAPK] and induced cyclin D1 in mid-G1 with kinetics similar to TGFalpha . Positive_regulation MAPK13 HBEGF 11171084 783794 Both p42 [MAPK] activation and mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation MAPK13 HBEGF 15380451 1298480 *induced* phosphorylation of ERK , p38 [MAPK] and Akt , which were suppressed by ZD1839 . Positive_regulation MAPK13 HBEGF 17928891 1858624 We report that cellular stress with methyl-beta-cyclodextrin ( MBCD ) , a molecule that extracts membrane cholesterol and thereby disrupts the structure of lipid rafts , strongly *induces* the synthesis of ( HB-EGF ) in keratinocytes through the activation of p38 [mitogen activated protein kinase] . Positive_regulation MAPK13 HBEGF 18990151 2028923 *Activation* of [Erk/MAPK] by was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation MAPK13 HBEGF 19048624 2023716 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked [MAPK] signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 MAPK , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Positive_regulation MAPK13 HBEGF 19559571 2110504 *induced* phosphorylation of p42/p44 [MAPK] in a few minutes . Positive_regulation MAPK13 HBEGF 20739666 2345889 Moreover , *induced* a stronger and more sustained activation of both the [mitogen activated protein kinase] and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation MAPK13 HBEGF 24188029 2921102 Here , we show that *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , [Mapk/Erk] pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation MAPK13 HRH1 11959800 931441 1. Previous studies have shown that the *activates* p42/p44 [mitogen activated protein kinases (MAPK)] in DDT ( 1 ) MF-2 smooth muscle cells via a phosphatidylinositol 3-kinase (PI-3K) dependent pathway . Positive_regulation MAPK13 HRH1 17965772 1820339 is *required* for TCR mediated p38 [MAPK] activation and optimal IFN-gamma production in mice . Positive_regulation MAPK13 HRH1 17965772 1820353 Moreover , signaling at the time of TCR ligation was *required* for activation of p38 [MAPK] , a known regulator of IFN-gamma expression . Positive_regulation MAPK13 IFI27 16953232 1682578 RET2A mediated regulation of p18 and , but not of cyclins D1 and D2 , *requires* functional [mitogen activated protein kinase] signaling . Positive_regulation MAPK13 IL1B 10640438 577504 and TNF alpha also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK13 IL1B 10704772 673005 CPI-1189 inhibits *induced* [p38-mitogen activated protein kinase] phosphorylation : an explanation for its neuroprotective properties ? Positive_regulation MAPK13 IL1B 10775561 686644 *activated* p44/42 [MAPK] , and this activation was enhanced in the presence of N-acetyl-L-cysteine . Positive_regulation MAPK13 IL1B 10864897 705726 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK13 IL1B 10864897 705778 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by TNF-alpha and . Positive_regulation MAPK13 IL1B 10864897 705798 TNF-alpha- and *induced* [ ( 3 ) H ] -thymidine incorporation and phosphorylation of p42/p44 [MAPK] was completely inhibited by PD98059 ( an inhibitor of MEK1/2 ) , indicating that activation of MEK1/2 was required for these responses . Positive_regulation MAPK13 IL1B 10969830 728486 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Positive_regulation MAPK13 IL1B 11032891 740454 *induces* p38 [MAPK] phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation MAPK13 IL1B 11037878 741241 also *stimulated* phosphorylation of p38 [MAPK] , SAPK/JNK , and ATF-2 . Positive_regulation MAPK13 IL1B 11126408 759773 TNFalpha and IFNgamma potentiate *induced* [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK13 IL1B 11126408 759786 [Mitogen activated protein kinase (MAPK)] activity that is *induced* by has been suggested to signal nitric oxide dependent as well as nitric oxide independent beta-cell destructive pathways . Positive_regulation MAPK13 IL1B 11126408 759799 The aim of this study was to investigate if TNFalpha and IFNgamma signal through mitogen activated protein kinases in isolated rat islets of Langerhans and if they potentiate [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK13 IL1B 11126408 759812 Further , TNFalpha and IFNgamma were found to synergistically increase [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK13 IL1B 11399523 824260 Glucose potentiates *induced* p38 [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK13 IL1B 11509550 848362 Although and TNF-alpha each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK13 IL1B 11557585 861403 *activated* the three [mitogen activated protein kinase] ( extracellular signal regulated kinases 1 and 2 , c-Jun NH2-terminal kinase/stress activated protein kinase , and p38 ) and the Janus kinase (JAK)-signal transducer and activator of transcription pathways . Positive_regulation MAPK13 IL1B 11698472 878052 *induced* phosphorylation and activation of p38 [MAPK] and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation MAPK13 IL1B 11698472 878098 *induced* phosphorylation of ERK and JNK as well as p38 [MAPK] in human endothelial cells . Positive_regulation MAPK13 IL1B 11728947 884809 We showed a dramatic decrease in *induced* phosphorylation of p38 [MAPK] , not extracellular signal regulated kinases 1/2 or jun NH2-terminal kinase , in rat cultured mesangial cells by FR167653 . Positive_regulation MAPK13 IL1B 11775830 766437 Role of protein tyrosine kinase in *induced* activation of [mitogen activated protein kinase] in fibroblast-like synoviocytes of rheumatoid arthritis . Positive_regulation MAPK13 IL1B 11853544 913371 Interestingly , *induced* p38 [MAPK] activity was greatly enhanced in ( alg+ ) compared with ( alg- ) cells . Positive_regulation MAPK13 IL1B 12117921 964665 mRNA expression by neutrophils was not dependent on p38 MAPK , and p38 [MAPK] was not *activated* in neutrophils incubated with A. phagocytophila . Positive_regulation MAPK13 IL1B 12131776 966859 and TNF-alpha *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK13 IL1B 12139924 969396 Regarding intracellular signaling , *activated* the p38 [mitogen activated protein kinase (MAPK)] but not the p42/p44 MAPK and , when combined with growth factors , intensified p38 activation but inhibited the growth-factor induced p42/p44 activation . Positive_regulation MAPK13 IL1B 12356282 993850 induced p44/42 [mitogen activated protein kinase (MAPK)] *activation* was inhibited by the MAPK/extracellular signal regulated protein kinase ( MEK ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK13 IL1B 12417253 1012953 Sphondin ( 50 microM ) did not affect the *induced* activations of p44/42 MAPK , p38 [MAPK] , and JNK . Positive_regulation MAPK13 IL1B 12500176 1026687 These data suggest that the presence of retinal holes and may *lead* to activation of HGF , [mitogen activated protein kinases (MAPK)] , c-jun and extracellular matrix remodeling , resulting in proliferative and migratory cells in the wounded retina . Positive_regulation MAPK13 IL1B 12507586 1038421 In this study we evaluated the role of epigallocatechin-3-gallate ( EGCG ) , a green tea polyphenol which mimics its anti-inflammatory effects , in modulating the induced *activation* of [MAPK] 's in human chondrocytes . Positive_regulation MAPK13 IL1B 12649265 1080067 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant MKK6 or p38beta2 MAPK inhibited induced p38 [MAPK] *activation* , COX-2 gene expression , and PGE2 release . Positive_regulation MAPK13 IL1B 12727980 1086557 P38 [MAPK] phosphorylation was *increased* by in nondecidualized ESC , whereas the IL-1 beta induced increase was suppressed in the decidualized cells . Positive_regulation MAPK13 IL1B 12727980 1086570 Treatment with 8-bromo-cAMP reduced *induced* phosphorylation of p38 [MAPK] in nondecidualized ESC . Positive_regulation MAPK13 IL1B 12727980 1086584 In contrast , treatment with H89 , a protein kinase A inhibitor , reversed a reduction in *induced* p38 [MAPK] phosphorylation in the decidualized cells . Positive_regulation MAPK13 IL1B 12727980 1086598 The altered property of decidualized cells is thought to be caused by attenuation of *induced* p38 [MAPK] phosphorylation in a way that involves the activation of the cAMP/protein kinase A pathway . Positive_regulation MAPK13 IL1B 12882449 1116289 NAC ( 1 mM ) also decreased the induced *activation* of p38 [MAPK] . Positive_regulation MAPK13 IL1B 12952251 1137417 Using Western-blot analysis , no effect of cAMP was found on the *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK13 IL1B 12952251 1137431 No decrease was observed in *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK13 IL1B 14563491 1154860 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Positive_regulation MAPK13 IL1B 15039421 1251235 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of , and RIP2 dependent *activation* of NF-kappaB and p38 [MAPK] mediated by the caspase recruitment domain . Positive_regulation MAPK13 IL1B 15111866 1241239 We further demonstrated that p38 MAPK is activated by and PDGF with different kinetics and that p38 [MAPK] is *required* for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation MAPK13 IL1B 15208668 1281343 *induced* the activation of extracellular signal regulated kinases-1/2 and P38 [mitogen activated protein kinase (MAPK)] , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation MAPK13 IL1B 15341531 1291761 In accordance with these findings , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) , which was attenuated by U0126 , SB202190 , or SP600125 , respectively . Positive_regulation MAPK13 IL1B 15389584 1354319 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] and JNK which was attenuated by pretreatment with U0126 or SP600125 , respectively . Positive_regulation MAPK13 IL1B 15489374 1359423 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and JNK was attenuated by pretreatment with U0126 , SB-202190 , or SP-600125 , respectively . Positive_regulation MAPK13 IL1B 15755725 1403421 The inhibitory effect of on alpha ENaC expression was *mediated* by the activation of p38 [MAPK] in both rat and human ATII cells and was independent of the activation of alpha v beta6 integrin and transforming growth factor-beta . Positive_regulation MAPK13 IL1B 16033422 1436165 Intrathecal *leads* to a time dependent up-regulation of phosphorylated p38 ( p-p38 ) [MAPK] protein expression in the spinal cord 30-240 min following IL-1beta injection ( i.t. ) . Positive_regulation MAPK13 IL1B 16033422 1436179 However , pretreatment with a p38 MAPK inhibitor significantly reduced the *induced* p-p38 [MAPK] expression by 38-49 % , and nearly completely blocked the subsequent iNOS expression ( reduction by 86.6 % ) , NO production , and thermal hyperalgesia . Positive_regulation MAPK13 IL1B 16043966 1459741 Western blot analysis demonstrated that *increased* the activation of phosphorylated MEK and p38 [MAPK] in GH3 cells . Positive_regulation MAPK13 IL1B 16140882 1450805 *induced* phosphorylation of [p38-MAPK] , but not that of c-Jun-N-terminal kinase or extracellular regulated kinase , was most susceptible to inhibition by low doses of PFE , and the addition of PFE blocked the activity of p38-MAPK in a kinase activity assay . Positive_regulation MAPK13 IL1B 16141635 1454869 DHA stimulated both rapid and prolonged activation of p44/42 , but not p38 , [mitogen activated protein kinase (MAPK)] *induced* by and PMA . Positive_regulation MAPK13 IL1B 16153910 1455437 The kidney was analyzed for expression of tumor necrosis factor alpha , , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 [mitogen activated protein kinase] , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation MAPK13 IL1B 16452991 1611737 Western blots showed that and TNF-alpha *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK13 IL1B 16528573 1549428 The aim of this study was to investigate if Gadd45b prevents *induced* beta cell [MAPK] signalling and apoptosis . Positive_regulation MAPK13 IL1B 16645161 1604677 significantly *increased* the phosphorylation of p38 [MAPK] and cPLA(2) . Positive_regulation MAPK13 IL1B 16698013 1575654 JST ( 0.01-1 mg/ml ) also attenuated the expression of cyclooxygenase (COX)-2 and activation of p38 [MAPK] *induced* by and A beta ( 1-42 ) . Positive_regulation MAPK13 IL1B 16718462 1584909 A synthetic peptide , C3d , reported to bind NCAM , did not activate MAPK or Akt as reported in neurons but inhibited *induced* [MAPK] activity , thereby mimicking the effect of SU5402 . Positive_regulation MAPK13 IL1B 16718462 1584934 We suggest that NCAM signalling through FGFR is required for efficient IL-1beta pro-apoptotic signalling by facilitating induced [MAPK] *activation* downstream of the NF-kappaB-MAPK branching point . Positive_regulation MAPK13 IL1B 16718462 1584969 Further , these data identify a novel function of C3d as an inhibitor of NCAM induced FGFR activity and of induced [MAPK] *activation* in beta cells . Positive_regulation MAPK13 IL1B 16959849 1639698 *caused* an increase in the phosphorylation of ERK , but not [p38MAPK] or c-Jun N-terminal kinase . Positive_regulation MAPK13 IL1B 16964394 1611554 Inhibitors of p38 [MAPK] and/or JNK significantly suppressed VEGF secretion both in the *presence* and absence of , while inhibitors of COX-2 , ERK1/2 , and PI3-K did not . Positive_regulation MAPK13 IL1B 17208222 1695813 Thalidomide also suppressed *induced* p38 [mitogen activated protein kinase (MAPK)] activation , while a p38 MAPK inhibitor destabilized COX-2 mRNA and the cytoplasmic shuttling of HuR induced by IL-1beta . Positive_regulation MAPK13 IL1B 17311279 1719290 *stimulated* phosphorylation of p42/p44 MAPK , p38 [MAPK] , and JNK was attenuated by pretreatment with U0126 , SB202190 , SP600125 , or transfection with these dominant negative mutants of MEK , ERK , p38 and JNK , respectively . Positive_regulation MAPK13 IL1B 17390080 1716134 We have previously demonstrated that *induced* HBD-2 mRNA expression in A549 cells through activation of nuclear factor-kappaB (NF-kappaB) transcriptional factor as well as p38 [mitogen activated protein kinase (MAPK)] , c-Jun N-terminal kinase (JNK) , or phosphatidylinositol-3-kinase (PI3K) . Positive_regulation MAPK13 IL1B 17390080 1716162 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Positive_regulation MAPK13 IL1B 17390080 1716192 Triptolide inhibited *induced* [MAPK] phosphatase-1 expression at the transcriptional level and resulted in sustained phosphorylation of JNK or p38 MAPK , explaining the little effect of triptolide on IL-1beta induced phosphorylation of these kinases . Positive_regulation MAPK13 IL1B 17438131 1742774 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by TNF-alpha and , but not by ansiomycin or sorbitol . Positive_regulation MAPK13 IL1B 17559635 1753262 also *activated* extracellular signal regulated kinase , p38 [MAPK] , and c-Jun N-terminal kinase . Positive_regulation MAPK13 IL1B 17645739 1793270 Interestingly , Dex attenuated mediated *activation* of p38 [MAPK] and JNK , but not of AKT . Positive_regulation MAPK13 IL1B 17694686 1782107 IL-1beta induced NO levels and thermal hyperalgesia in rats , likely via either inhibiting the mediated p38 [MAPK] *activation* and subsequent iNOS induction , or direct attenuation of the central iNOS activity , which therefore reduces the central sensitization of inflammatory pain . Positive_regulation MAPK13 IL1B 17920534 1804190 SA981 at a concentration of 100 microM partially inhibited *induced* phosphorylation of [p38MAPK] and Akt ( 12.0 % and 36.1 % inhibition of each total amount of phosphoprotein under IL-1beta coexistence condition , respectively ) . Positive_regulation MAPK13 IL1B 17925024 1835154 *stimulated* phosphorylation of c-jun amino-terminal kinase , p38 [MAPK] and extracellular signal regulated kinase-1/2 . Positive_regulation MAPK13 IL1B 18026701 1827821 Moreover , glucosamine suppressed the *induced* phosphorylation of p38 [MAPK] ( p < 0.05 at > 0.1 mM ) and the IL-1beta binding to its receptors ( p < 0.05 at 1 mM ) . Positive_regulation MAPK13 IL1B 18065201 1853663 *stimulated* activation of ERK1/2 and p38alpha [MAPK] mediates the transcriptional up-regulation of IL-6 , IL-8 and GRO-alpha in HeLa cells . Positive_regulation MAPK13 IL1B 18348730 1925315 The *activation* or inhibition of p38 [MAPK] by and/or SB203580 was analyzed by western blotting . Positive_regulation MAPK13 IL1B 18348730 1925328 *activated* the phosphorylation of p38 [MAPK] and this effect was abolished by SB203580 . Positive_regulation MAPK13 IL1B 18427719 1920723 Phosphorylated p38 ( Phos-p38 ) [mitogen activated protein kinase] was *stimulated* in SW-1353 cells by but not by HA alone . Positive_regulation MAPK13 IL1B 18556347 1965931 or leptin individually *induced* threonine/tyrosine phosphorylation of p38 [MAPK] , whereas only leptin induced tyrosine phosphorylation of JAK2 , suggesting that leptin may enhance hBD-2 production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with NF-kappaB , which is activated by IL-1beta . Positive_regulation MAPK13 IL1B 18667841 1948052 Furthermore , induced p38 [mitogen activated protein kinase (MAPK)] *activation* and upregulation of VEGF-C mRNA and protein in LLC cells was also suppressed by artemisinin or by the p38 MAPK inhibitor SB-203580 , suggesting that p38 MAPK could serve as a mediator of proinflammatory cytokine induced VEGF-C expression . Positive_regulation MAPK13 IL1B 19362079 2081459 *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 [mitogen activated protein (MAP) kinase] , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation MAPK13 IL1B 19522843 2136339 In chondrocytes , CS diminishes *induced* increases in p38 [mitogen activated protein kinase] ( p38MAPK ) and signal regulated kinase 1/2 ( Erk1/2 ) phosphorylation , and decreases nuclear factor-kappaB (NF-kappaB) nuclear translocation and as a consequence , reduces the formation of pro-inflammatory cytokines , IL-1beta and TNF-alpha , and pro-inflammatory enzymes , such as phospholipase A2 (PLA2) , cyclooxygenase 2 (COX-2) and nitric oxide synthase-2 (NOS-2) . Positive_regulation MAPK13 IL1B 19765281 2163523 Treatment with PIP-18 blocked *induced* p38 [MAPK] phosphorylation and resulted in attenuation of sPLA2-IIA and MMP mRNA transcription in RA SF cells . Positive_regulation MAPK13 IL1B 20060906 2218521 In the present study , we demonstrate that *caused* activation of p38 [mitogen activated protein kinase] and that the p38 inhibitor SB203580 significantly blocked the effect of IL-1beta on I ( NMDA-OUT ) in hippocampal CA1 neurons . Positive_regulation MAPK13 IL1B 20353947 2266468 In model 1 , a differentiation model , CLA *activation* of [MAPK] and induction of interleukin-8 (IL-8) , IL-6 , , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation MAPK13 IL1B 21659536 2455194 Distinct roles for Nod2 protein and autocrine in muramyl dipeptide *induced* [mitogen activated protein kinase] activation and cytokine secretion in human macrophages . Positive_regulation MAPK13 IL1B 24692548 2935245 At 1 h , this was responsible for the dexamethasone inhibition of *induced* [MAPK] activation and CXCL1 and CXCL2 mRNA expression , with a similar trend for CSF2 . Positive_regulation MAPK13 IL1B 9475519 486791 Of these , *activated* only [MAPK] . Positive_regulation MAPK13 IL1B 9475519 486804 In cultured rat astrocytes , *caused* activation of [MAPK] without inducing proliferation . Positive_regulation MAPK13 IL1B 9575890 502735 Our data also indicate that both insulin and IGF-I enhance *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation and SAPK activation . Positive_regulation MAPK13 IL1B 9582321 503936 Previously we reported that *induces* activation of JNK/SAPK and p38 [MAPK] with concomitant up-regulation of cyclooxygenase (Cox)-2 expression and prostaglandin E2 ( PGE2 ) synthesis . Positive_regulation MAPK13 IL1B 9614146 509329 By Western blotting with phosphospecific antibodies and by immunocomplex kinase assay , was shown to *activate* extracellular signal regulated kinase ( ERK ) 1/2 and p38 [mitogen activated protein kinase] ( p38 ) in islets and rat insulinoma cells . Positive_regulation MAPK13 IL1B 9786861 540914 We reported previously that rapidly *activates* the c-Jun NH2-terminal/stress activated protein kinases ( JNK/SAPK ) and p38 [mitogen activated protein kinase (MAPK)] and also induces Cox-2 expression and prostaglandin E2 ( PGE2 ) production . Positive_regulation MAPK13 IL1B 9786861 540960 Overexpression of the kinase-dead form of MKK3 or MKK6 demonstrated that either of these two mutant kinases inhibited *induced* p38 [MAPK] phosphorylation and Cox-2 expression but not JNK/SAPK phosphorylation and activation . Positive_regulation MAPK13 ITGB2 12600815 1099064 IL-3 , IL-5 , and GM-CSF could enhance p38 [MAPK] and NF-kappaB activity and *induce* ICAM-1 , CD11b , and expressions on eosinophils . Positive_regulation MAPK13 ITGB2 19843511 2203201 Furthermore , beta2 integrins modulated the capacity of isolated peritoneal macrophages to take up acetylated LDL and native LDL and to phagocytose apoptotic cells , possibly via *dependent* [mitogen activated protein kinase] signalling . Positive_regulation MAPK13 LBP 20615568 2309941 Despite activating NFkappaB , NOD1 ligand did not upregulate hepatocyte production of the acute phase proteins lipopolysaccharide binding protein , serum amyloid A , or soluble CD14 in cell culture supernatants , or upregulate mRNA expression of , serum amyloid A , C-reactive protein , or serum amyloid P . NOD2 ligand ( MDP ) did not *activate* hepatocytes when given alone , but did synergize with Toll-like receptor ligands , lipopolysaccharide (LPS) , and polyI : C to activate NFkappaB and [MAPK] . Positive_regulation MAPK13 MAP2K6 10050043 592940 In one set of experiments , we *inhibited* the activation of [MAPK] by pretreating cells with PD098059 , a specific inhibitor of ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAPK13 MAP2K6 10079106 595482 Although MKK3 , MKK4 , and all *activated* p38 [MAPk] in experimental models , only MKK3 was found to activate recombinant p38 MAPk in LPS treated neutrophils . Positive_regulation MAPK13 MAP2K6 10471331 641620 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Positive_regulation MAPK13 MAP2K6 10601295 574415 In addition , *activation* of p38 [MAPK] by constitutively active or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAPK13 MAP2K6 10713051 674388 Conversely , the inhibitors PD98059 and UO126 could *attenuate* EGF induced [mitogen activated protein kinase] activation , they do not affect the EGF induced mobility shift of caveolin-1 . Positive_regulation MAPK13 MAP2K6 10759527 683159 These results demonstrate that a plant can phosphorylate and *activate* [MAPK] , and that Tyr phosphorylation is critical for the catalytic activity of MAPK in plants . Positive_regulation MAPK13 MAP2K6 10816593 714747 The MAPK kinase selectively *stimulates* p38 [MAPK] and confers protection against stress induced apoptosis in cardiac myocytes . Positive_regulation MAPK13 MAP2K6 10891559 711203 MAP kinases (MAPK) in both G-1 and G-5 cells were indistinguishably phosphorylated , yet *dependent* [MAPK] activation was observed only in G-5 cells . Positive_regulation MAPK13 MAP2K6 11005808 752430 A inhibitor , PD98059 , *inhibited* heat shock ERK [MAPK] activation by > 75 % . Positive_regulation MAPK13 MAP2K6 11085935 750730 Similarly , *activation* of JNK by Ad-MKK7D and [p38-MAPK] by resulted in the increased expression of PGHS-2 . Positive_regulation MAPK13 MAP2K6 11237743 790315 The MAPK kinase ( ) inhibitor , PD98059 , *blocked* GSA stimulated [MAPK] activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Positive_regulation MAPK13 MAP2K6 11304531 826833 The *activation* of p38 [MAPK] by Galpha ( q ) and Gbetagamma was blocked by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Positive_regulation MAPK13 MAP2K6 11787422 891937 Indeed the MAPK kinase ( = ) inhibitor PD98059 *inhibits* the activation of parasite [MAPK] , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Positive_regulation MAPK13 MAP2K6 11822870 909065 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of [MAPK] pathway *inhibitors* ( inhibitors PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAPK13 MAP2K6 12009309 940823 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Positive_regulation MAPK13 MAP2K6 12203369 983229 Furthermore , PKC inhibitors or an inhibitor completely *suppressed* both TPA induced activation of [MAPK] and promotion of anchorage independent growth , but a cPKC-selective inhibitor partially suppressed TPA induced promotion of the growth . Positive_regulation MAPK13 MAP2K6 12356282 993856 IL-1beta induced p44/42 [mitogen activated protein kinase (MAPK)] activation was *inhibited* by the MAPK/extracellular signal regulated protein kinase ( ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK13 MAP2K6 12377770 1019988 These results suggest that MKK3 , rather than , *mediates* alphav integrin induced p38 [MAPK] activation . Positive_regulation MAPK13 MAP2K6 12450322 1018647 ANG II significantly increased aldosterone release , and this effect was inhibited by the LO inhibitor baicalein , as well as a specific p38 [MAPK] *inhibitor* , SB202190 , but not by PD098059 , a specific inhibitor of the ERK activator . Positive_regulation MAPK13 MAP2K6 12637559 1085486 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Positive_regulation MAPK13 MAP2K6 12659851 1073519 MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a ( MAP2K ) , which in turn *activates* a [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK13 MAP2K6 12845643 1108599 Finally , both ODQ and UO126 blocked the capacity of L-arginine to restore ERK ( 1/2 ) phosphorylation in L-NAME treated cells , demonstrating that GC and are both *required* for endogenous NO-mediated [MAPK] activation . Positive_regulation MAPK13 MAP2K6 15104236 1240315 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( ) inhibitor , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAPK13 MAP2K6 15172888 1288392 Importantly , the presence of inhibitors only at the time of the transport assay markedly *impaired* both insulin stimulated glucose uptake and [MAPK] signaling . Positive_regulation MAPK13 MAP2K6 15172888 1288490 Conversely , removal of inhibitors before the transport assay *restored* glucose uptake and [MAPK] signaling . Positive_regulation MAPK13 MAP2K6 15304546 1322517 Furthermore , *activation* of [ERK/MAPK] by the coexpression of constitutively active predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAPK13 MAP2K6 15365248 1294575 Treatment of keratinocytes with PD98059 , inhibitor , and SB20358 , p38 [MAPK] *inhibitor* , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAPK13 MAP2K6 15570612 1355571 Although the inhibitors *suppressed* [MAPK] phosphorylation in both OA- and AICAR treated oocytes , meiotic resumption was not causally linked to MAPK phosphorylation in either group . Positive_regulation MAPK13 MAP2K6 15867183 1404243 In cultured cardiac myocytes , specific *activation* of stress activated [mitogen activated protein kinase] , p38 , by upstream activator led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAPK13 MAP2K6 15879307 1411358 Conversely , constitutively active *induced* p38 [MAPK] activation that recapitulated the effects of polyphenols by inducing ERalpha phosphorylation and downstream activation of Akt , and eNOS . Positive_regulation MAPK13 MAP2K6 16157033 1455767 SB203580 , a [P38MAPK] *inhibitor* , and U0126 , a inhibitor , both completely blocked ADM mediated responses in MsC . Positive_regulation MAPK13 MAP2K6 17416211 1777885 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK13 MAP2K6 18401006 1925834 CyaA enhanced LPS induced phosphorylation of p38 [MAPK] and ERK in DC , and inhibitors of p38 MAPK , , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation MAPK13 MAP2K6 18754769 1968443 ( MKK) 3 and 6 are the main p38 [mitogen activated protein kinase] *activators* in mammals . Positive_regulation MAPK13 MAP2K6 18771907 1962688 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a inhibitor , and SB203580 , an *inhibitor* of p38 [mitogen activated protein (MAP) kinase] , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAPK13 MAP2K6 21892182 2491663 Further , we show that *activation* of p38 [MAPK] by expression of constitutively active ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAPK13 MAP2K6 22164285 2517911 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of and marked *activation* of p38 [MAPK] . Positive_regulation MAPK13 MAP2K6 22785235 2691901 TRH induced CRE promoter was inhibited by [mitogen activated protein kinase/ERK] kinase ( MEK ) inhibitor and was *increased* by overexpression of . Positive_regulation MAPK13 MAP2K6 7644477 318672 Inhibition of by PD 098059 *prevented* activation of [MAPK] and subsequent phosphorylation of MAPK substrates both in vitro and in intact cells . Positive_regulation MAPK13 MAP2K6 7822248 285605 ( MKK ) phosphorylates and *activates* [mitogen activated protein kinase (MAPK)] in response to stimulation of various eukaryotic signaling pathways . Positive_regulation MAPK13 MAP2K6 7889302 289449 2. Both nucleotides stimulate phosphorylation and *activation* of [mitogen activated protein kinase] and a biphasic phosphorylation of the up-stream . Positive_regulation MAPK13 MAP2K6 8180183 256249 This stimulation of the activator was temporally *followed* by increased activities of MEK and [MAPK] . Positive_regulation MAPK13 MAP2K6 8226933 235420 *Activation* of extracellular signal regulated kinase ( ERK ) or [mitogen activated protein kinase] by ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAPK13 MAP2K6 8394352 228250 We show that a similar activity phosphorylates and *activates* [MAPK] in both growth factor stimulated ( epidermal growth factor and thrombin ) and oncogene ( gip2 , v-src , and v-raf ) -transfected cells . Positive_regulation MAPK13 MAP2K6 8550616 346678 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Positive_regulation MAPK13 MAP2K6 8663100 368167 The [MAPK] and NHE activities induced by PMA were *inhibited* by staurosporine , a potent inhibitor for protein kinase C ( PKC ) , and by MAPK kinase ( ) inhibitor , PD98059 , but were not affected by the tyrosine kinase inhibitor genistein . Positive_regulation MAPK13 MAP2K6 8663100 368263 In contrast , both AVP induced [MAPK] and NHE activities were *inhibited* by genistein and inhibitor but were not affected by staurosporine . Positive_regulation MAPK13 MAP2K6 8816498 384304 *activates* [mitogen activated protein kinase (MAPK)] , which phosphorylates other kinases as well as transcription factors . Positive_regulation MAPK13 MAP2K6 9135064 427621 In addition to *dependent* [MAPK] activation , we provide evidence for MEK independent regulation of the MAPKs . Positive_regulation MAPK13 MAP2K6 9166761 432469 The first step in [MAPK] *activation* by must be the formation of a MEK x MAPK enzyme-substrate complex , followed by phosphorylation producing monophosphorylated MAPK ( pMAPK ) . Positive_regulation MAPK13 MAP2K6 9626658 511901 These results indicate that *mediates* the IGF-I/insulin induced p42/ p44 [MAPK] activation . Positive_regulation MAPK13 MAP2K6 9864179 582738 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of ERK , but not p38 [MAPK] , induced by G-CSF , GM-CSF , or TNF . Positive_regulation MAPK13 MMP7 16848631 1588321 and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 [mitogen activated protein kinase] activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MAPK13 MMP7 21999204 2547385 Mesothelin enhances invasion of ovarian cancer by *inducing* through [MAPK/ERK] and JNK pathways . Positive_regulation MAPK13 MUC16 11481474 843864 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a [mitogen activated protein kinase] ( Erk 1/2 ) , and *activation* of transcription . Positive_regulation MAPK13 PECAM1 18029285 1866922 In contrast , expression of Delta15 in PECAM-1-/- bEND cells *had* minimal effects on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Positive_regulation MAPK13 PGC 22105890 2599542 Our studies also revealed that overexpression of in cardiomyocytes *inhibited* basal and T3-induced p38 [MAPK] phosphorylation . Positive_regulation MAPK13 PIGR 20450283 2257148 Induction of expression in HT-29 cells *required* NF-kappaB signaling but not [MAPK] signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation MAPK13 PLAT 19436314 2107039 cerebrospinal fluid and brain parenchymal ERK [MAPK] was elevated by H/I and this upregulation was *potentiated* by , but blunted by RBC-tPA . Positive_regulation MAPK13 PLAT 21037505 2499495 Red blood blocked c-Jun-N-terminal kinase but *potentiated* p38 [mitogen activated protein kinase] upregulation after photothrombotic injury . Positive_regulation MAPK13 PLAU 10766865 684605 surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha [mitogen activated protein kinase] activity . Positive_regulation MAPK13 PLAU 15031204 1257169 In HeLa cells the dominant negative form of JNK interferes with the p42/p44 [MAPK] *activation* of the . Positive_regulation MAPK13 PLAU 15874933 1405698 Activation of the [mitogen activated protein kinases (MAPK)] , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Positive_regulation MAPK13 PLAU 15874933 1405731 Although uPA induced phosphorylation of both ERK1/2 and p38 MAPK was blocked by Galphai inhibition , inhibition of PI3K and Ras decreased the *induced* phosphorylation of ERK1/2 but not p38 [MAPK] . Positive_regulation MAPK13 PLAU 18656457 1960564 Exogenous administered at 4 h post H/I further *stimulated* ERK [MAPK] phosphorylation , which was blocked by RAP . Positive_regulation MAPK13 PLAU 9660790 517499 The receptor *mediates* tyrosine phosphorylation of focal adhesion proteins and activation of [mitogen activated protein kinase] in cultured endothelial cells . Positive_regulation MAPK13 PLAU 9660790 517512 The induced *activation* of [MAPK] was completely inhibited by genistein , but not by 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo [ 3 , 4-d ] pyrimidine , a specific inhibitor of Src family kinases . Positive_regulation MAPK13 PODXL 17616675 1769273 expression also *led* to an increase in [mitogen activated protein kinase (MAPK)] and phosphatidylinositol 3-kinase (PI3K) activity . Positive_regulation MAPK13 PODXL 17616675 1769320 These findings suggest that leads to increased in vitro migration and invasion , increased MMP expression , and *increased* activation of [MAPK] and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MAPK13 PTGER2 19233324 2072059 Further , PGE ( 2 ) , EP2A and EP4A did not increase BMP2/4 mRNA levels in RC cells , and *induced* phosphorylation of p38 [MAPK] was not eliminated by Noggin . Positive_regulation MAPK13 SLC38A3 15331357 1288017 In contrast , *stimulated* [MAPK] activation was blocked by > 80 % by dominant negative Ras but not by dominant negative Rho and Cdc42 . Positive_regulation MAPK13 SNCAIP 12639553 1068703 In addition , [MAPK] was *activated* by through Edg-1 , Sph-1-P receptor . Positive_regulation MAPK13 SPHK1 18602364 1941504 As a result , inhibition of by SKI *blocked* phosphorylation of p38 [MAPK] , showing that SPHK activation by IL-18 is an upstream signal of p38 MAPK activation . Positive_regulation MAPK13 STK39 17237610 1690271 The phosphorylation of cytoplasmic p38 [MAPK] in Akata cells was *reduced* by the inhibitor , 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperazine ( H7 ) . Positive_regulation MAPK13 TLR7 16424221 1515565 MKP-1-deficient macrophages also show enhanced constitutive and *induced* activation of p38 [MAPK] . Positive_regulation MAPK13 TLR7 23979601 2850645 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Positive_regulation MAPK13 TLR7 24879442 2940996 GIT2 terminates *induced* NF-?B and [MAPK] signaling by recruiting the deubiquitinating enzyme Cylindromatosis to inhibit the ubiquitination of TRAF6 . Positive_regulation MAPK13 TNF 10504489 648982 Pretreatment with SB203580 ( 10 microM ) had no effect on basal or TNF-alpha stimulated phosphorylation of p38 MAPK but completely abolished *stimulated* p38 [MAPK] activity . Positive_regulation MAPK13 TNF 10521481 653112 The study presented here shows that autoregulation of gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 [mitogen activated protein (MAP) kinase] activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation MAPK13 TNF 10570180 568160 Furthermore , LPS , UV irradiation , and *caused* activation of p38 [MAPK] whereas IFN-gamma did not . Positive_regulation MAPK13 TNF 10601128 574203 alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation MAPK13 TNF 10640438 577503 IL-1 beta and also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK13 TNF 10669634 665807 In this study , we show that *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation MAPK13 TNF 10753884 682342 Moreover , *stimulated* both the NF-kappaB and [mitogen activated protein (MAP) kinase] ( extracellular signal regulated kinase , c-Jun NH ( 2 ) -terminal kinase , and p38 MAP kinase ) signaling pathways in astrocytes . Positive_regulation MAPK13 TNF 10783388 707849 *dependent* p38 [MAPK] activation was detected in both Mo7e and Hut-78 cells and was blocked by the p38 MAPK inhibitor , SB203580 . Positive_regulation MAPK13 TNF 10783388 707902 SB203580 did not affect TNF-alpha signaled nuclear translocation and DNA binding activity of NF-kappaB , and inhibition of NF-kappaB function did not affect induced p38 [MAPK] *activation* , indicating that these events are not dependent on each other . Positive_regulation MAPK13 TNF 10864897 705725 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK13 TNF 10864897 705777 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by and IL-1beta . Positive_regulation MAPK13 TNF 11095634 755299 rapidly *activated* [MAPK] and increased the extent of attachment , spreading and migration on fibronectin and collagen type I ( P < 0.01 ) but not on collagen type IV . Positive_regulation MAPK13 TNF 11108246 756728 *activates* extracellular regulated kinase-1/2 ( ERK1/2 ) and [p38MAPK] . Positive_regulation MAPK13 TNF 11108836 757039 In RAW264 cells which differentiate into osteoclast-like multinucleated cells by TNF treatment alone , activation of p38 [mitogen activated protein (MAP) kinase] *induced* by murine was comparable to and independent of the receptor activator of necrosis factor-kappaB ligand . Positive_regulation MAPK13 TNF 11156586 780615 1. We have previously shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce interleukin-8 (IL-8) by human pulmonary vascular endothelial cells . Positive_regulation MAPK13 TNF 11167962 783066 It has previously been shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce cytokine , including RANTES , that N-acetylcysteine (NAC) attenuates cytokine production by human bronchial epithelial cells ( BECs ) , and that sensitivity to TNFalpha is inversely correlated with cellular redox state . Positive_regulation MAPK13 TNF 11266661 797169 However , *caused* no activation of p42/p44 [MAPK] or cytosolic phospholipase A(2) activity . Positive_regulation MAPK13 TNF 11277995 798111 *activates* extracellular regulated kinases ( ERKs ) and p38 [mitogen activated protein kinase] ( p38MAPK ) , and inhibits the expression of uncoupling protein-1 (UCP-1) and adipocyte-specific genes in rat fetal brown adipocytes . Positive_regulation MAPK13 TNF 11319753 806839 SB 203580 , a selective inhibitor of p38 MAPK , inhibited IL-1 and *induced* p38 [MAPK] activity and IL-6 production ( IC ( 50 ) s 0.3 -- 0.5 microM ) in osteoblasts and chondrocytes . Positive_regulation MAPK13 TNF 11319753 806862 In addition , IL-1 and also *activated* p38 [MAPK] in fetal rat long bones and p38 MAPK inhibitors inhibited IL-1- and TNF stimulated bone resorption in vitro in a dose dependent manner ( IC ( 50 ) s 0.3 -- 1 microM ) . Positive_regulation MAPK13 TNF 11435466 832529 However , the cytotoxic responses to daunorubicin and exogenous ceramide remain unaltered , as do the *induced* p42/p44 [MAPK] activation and CD54 expression . Positive_regulation MAPK13 TNF 11438547 843394 *activated* p38 [MAPK] and p44/p42 MAPK in wild-type but not in p60 ( -/- ) , p80 ( -/- ) , or p60 ( -/- ) p80 ( -/- ) macrophages . Positive_regulation MAPK13 TNF 11494147 846173 In this study we demonstrate that *triggers* only modest proliferation , as well as p44/p42 [mitogen activated protein kinase (MAPK)] and NF-kappaB activation , in MM.1S multiple myeloma ( MM ) cells . Positive_regulation MAPK13 TNF 11495721 846392 Furthermore , overexpression of dominant negative mutants , H-Ras-15A and Raf-N4 , significantly suppressed p42/p44 [mitogen activated protein kinase (MAPK)] activation *induced* by and PDGF-BB and attenuated the effect of TNF-alpha on BK-induced IP response , indicating that Ras and Raf may be required for activation of these kinases . Positive_regulation MAPK13 TNF 11509550 848360 Although IL-1 beta and each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK13 TNF 11592111 869661 Lipopolysaccharide (LPS) treatment of a microglial cell line ( N9 ) *induced* a time dependent activation of both p38 mitogen activated protein kinase ( p38 [MAPK] ) and nuclear factor-kappaB (NFkappaB) , with consequent increases in interleukin-1alpha (IL-1alpha) , , and nitric oxide ( NO ) production . Positive_regulation MAPK13 TNF 11694522 896414 *activated* the three mammalian [MAPK] , p44/42 , JNK , and p38 , in a distinct time- and concentration dependent manner . Positive_regulation MAPK13 TNF 11694522 896440 In conclusion , although *activates* all three known [MAPK] in human preadipocytes , only p44/42 and JNK appear to be involved in the regulation of lipolysis . Positive_regulation MAPK13 TNF 11750919 898172 Biochemical and immunocytochemical analysis showed that *activated* p38 [mitogen activated protein kinase] ( p38MAPK ) and c-Jun N-terminal kinase (JNK) but not p42/p44 MAPK . Positive_regulation MAPK13 TNF 11820362 908739 *activated* p38 [MAPK] and stimulated IL-6 secretion by MG-63 cells , and pre-incubation of cells with the p38 MAPK inhibitor abrogated TNF-alpha dependent IL-6 secretion . Positive_regulation MAPK13 TNF 11820362 908768 Transfection of IL-6 full-length and 5-deletion gene promoter reporter constructs indicated that p38 [MAPK] *activation* by enhanced IL-6 gene expression , and that the p38 MAPK-responsive region resided in the proximal 260-bp segment . Positive_regulation MAPK13 TNF 11820362 908804 In conclusion , although p38 [MAPK] *activation* by stimulates IL-6 secretion by MG-63 cells , it has opposing effects on c/EBPbeta and NFkappaB activity . Positive_regulation MAPK13 TNF 11930247 927419 The p44/42 [MAPK] activity was significantly *enhanced* by and the TNF-alpha effect was opposed by rhIL-10 . Positive_regulation MAPK13 TNF 11930247 927432 It is suggested that rhIL-10 can inhibit *induced* VSMC proliferation and phosphorylation of p44/42 [MAPK] . Positive_regulation MAPK13 TNF 12095140 960565 significantly increased permeability and *induced* p38 and ERK [MAPK] activation compared with controls ( P < 0.05 ) . Positive_regulation MAPK13 TNF 12114204 963995 *increased* the phosphorylation of p38 MAPK within 15 min. Anisomycin , an activator of p38 MAPK , increased p38 [MAPK] phosphorylation and decreased SP-A mRNA levels in a dose dependent manner . Positive_regulation MAPK13 TNF 12130576 966580 Phosphorylation of p38 [MAPK] was *induced* by RANKL , IL-1 , , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation MAPK13 TNF 12131776 966858 IL-1 beta and *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK13 TNF 12297009 991038 In this study , we examined the anti-apoptotic role of p38 [MAPK] that is *activated* by in neuronal PC12 cells . Positive_regulation MAPK13 TNF 12297009 991051 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Positive_regulation MAPK13 TNF 12393915 1025435 This model probiotic also inhibits *activation* of the pro-apoptotic [p38/mitogen activated protein kinase] by , interleukin-1alpha , or gamma-interferon . Positive_regulation MAPK13 TNF 12511413 1079037 The treatment of RAW264 cells with TSA and NaB inhibited *induced* nuclear translocation of NF-kappa B and sRANKL induced activation of p38 [mitogen activated protein kinase (MAPK)] signals . Positive_regulation MAPK13 TNF 12631113 1067616 Additional experiments examining the role of cAMP on MC fractalkine expression showed that the incubation of MCs with TNF-alpha and either db-cAMP or forskolin attenuated TNF-alpha stimulated fractalkine mRNA and protein expression , preceded by attenuation of *activated* phosphorylation of p42/44 [MAPK] , and c-Jun , but not phosphorylation of PKCzeta/iota or nuclear translocation of NF-kappaB . Positive_regulation MAPK13 TNF 12637577 1099308 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and *requires* p38 [MAPK] activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation MAPK13 TNF 12665666 1030371 This study was undertaken to examine the relationship between *induced* cardiomyocyte apoptosis and activation of p38 [mitogen activated protein kinase (MAPK)] through oxidative stress . Positive_regulation MAPK13 TNF 12665666 1030384 Corresponding to the apoptotic effect , at 10 ng/mL *caused* rapid phosphorylation of p38 [MAPK] in wild-type cardiomyocytes . Positive_regulation MAPK13 TNF 12694807 1080910 *induced* the phosphorylation of p44/p42 [mitogen activated protein (MAP) kinase] and p38 MAP kinase . Positive_regulation MAPK13 TNF 12731668 1086846 On the other hand , GM-CSF- or *induced* phosphorylation of ERK and p38 [MAPK] was unaffected by these inhibitors at the concentrations effective for the inhibition of O2- release and adherence . Positive_regulation MAPK13 TNF 12829618 1113805 However , *induced* [p38-MAPK] phosphorylation was markedly diminished in mkk3-/- vs mkk3+/+ hearts ( percent basal , 127+/-23 versus 540+/-267 , respectively , P=0.04 ) , suggesting an MKK independent activation mechanism by ischemia . Positive_regulation MAPK13 TNF 12844496 1149729 Rho inhibition decreases induced endothelial [MAPK] *activation* and monolayer permeability . Positive_regulation MAPK13 TNF 12844496 1149742 Because GTP binding proteins have been implicated in MAPK activation , we now hypothesize that the GTP binding protein Rho is a mediator of induced [MAPK] *activation* and increased endothelial permeability . Positive_regulation MAPK13 TNF 12844496 1149756 C3 transferase attenuated induced [MAPK] *activation* and blocked TNF induced endothelial permeability . Positive_regulation MAPK13 TNF 12867430 1141992 Subsequently , mediated p38 [MAPK] *activation* induced sialidase activity and CD44-HA binding . Positive_regulation MAPK13 TNF 12867430 1142106 Taken together , our results suggest that *induced* p38 [MAPK] activation may regulate the induction of functionally active HA-binding form of CD44 by activating sialidase in LPS stimulated human monocytic cells . Positive_regulation MAPK13 TNF 12881424 1116131 Importantly , does not *induce* ROS accumulation or prolonged [MAPK] activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death Positive_regulation MAPK13 TNF 12893778 1121029 We show that MKK3 and MKK6are essential for *stimulated* p38 [MAPK] activation . Positive_regulation MAPK13 TNF 12960255 1158287 To investigate a potential interplay between induced *activation* of p38 [MAPK] and NF-kappaB , the p38 MAPK inhibitor SB203580 and a dominant negative p38 MAPK mutant were used . Positive_regulation MAPK13 TNF 14516792 1147203 [MAPK] pathway *activation* via was confirmed by marked AP-1 activation detected in EMSA . Positive_regulation MAPK13 TNF 14561851 1165105 In cultured human umbilical vein endothelial cells ( HUVECs ) , and lipopolysaccharide *increased* phosphorylation of p38 [MAPK] ( P-p38 MAPK ) and increased ICAM-1 expression . Positive_regulation MAPK13 TNF 14592823 1209464 Analyzing the individual contribution of PF-4 and its costimuli in the control of these functions at the signaling level , we demonstrate that induced *activation* of p38 [mitogen activated protein (MAP) kinase] ( but not extracellular regulated kinase [ Erk ] kinases ) acts as general and essential costimulatory signal in PF-4 dependent neutrophil exocytosis . Positive_regulation MAPK13 TNF 14632659 1170650 *activated* p38 [MAPK] in DCs only at an early time-point ( 15 min ) . Positive_regulation MAPK13 TNF 14654378 1176828 These findings suggest that the pre-ischemic *activation* of [p38-MAPK] by does not contribute to cardioprotection afforded by this agent . Positive_regulation MAPK13 TNF 15002040 1265080 Consistent with the abrogation of osteoclastogenic effect of DcR3 by TNFR-Fc , DcR3 treatment can *induce* osteoclastogenic cytokine release through ERK and p38 [MAPK] signaling pathways . Positive_regulation MAPK13 TNF 15139014 1246957 The increase in release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not [mitogen activated protein kinase (MAPK)] , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation MAPK13 TNF 15191888 1295239 Treatment of endothelial cells with SphK1 siRNA suppressed *induced* increase in MCP-1 mRNA levels , MCP-1 protein secretion , and activation of p38 [MAPK] . Positive_regulation MAPK13 TNF 15212763 1262316 Interestingly , Ad5NIK , but not , *induces* RelA S536 and p38 [mitogen activated protein kinase (MAPK)] phosphorylation in IKKgamma ( -/- ) cells . Positive_regulation MAPK13 TNF 15233873 1269390 A. semen also inhibited the expression of and the *activation* of [mitogen activated protein kinase] , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation MAPK13 TNF 15240695 1270282 TNF activates Syk protein tyrosine kinase leading to *induced* [MAPK] activation , NF-kappaB activation , and apoptosis . Positive_regulation MAPK13 TNF 15240695 1270302 TNF induced Syk activation was abolished by piceatannol ( Syk-selective inhibitor ) , which led to the suppression of induced *activation* of c- JNK , p38 MAPK , and p44/p42 [MAPK] . Positive_regulation MAPK13 TNF 15240695 1270318 Jurkat cells that did not express Syk ( JCaM1 , JCaM1/lck ) showed lack of *induced* Syk , JNK , p38 [MAPK] , and p44/p42 MAPK activation , as well as TNF induced IkappaBalpha phosphorylation , IkappaBalpha degradation , and NF-kappaB activation . Positive_regulation MAPK13 TNF 15240695 1270349 Overall , our results demonstrate that Syk activation plays an essential role in induced *activation* of JNK , p38 MAPK , p44/p42 [MAPK] , NF-kappaB , and apoptosis . Positive_regulation MAPK13 TNF 15240725 1270457 p38 [MAPK] was *activated* by and oxidants in nonadherent conditions i.e. , with 10 mM EDTA . Positive_regulation MAPK13 TNF 15240725 1270471 Finally , p38 [MAPK] *activation* by was blocked by diphenylene iodonium , an inhibitor of flavoprotein oxidoreductase , and by the free radical scavenger N-acetylcystein . Positive_regulation MAPK13 TNF 15265936 1275733 Besides NF-kappa B , celecoxib also suppressed *induced* JNK , p38 [MAPK] , and ERK activation . Positive_regulation MAPK13 TNF 15290420 1278550 Halothane or isoflurane augmented the LPS- and *induced* activation of p38 [MAPK] . Positive_regulation MAPK13 TNF 15304089 1284479 DNCB , NiSO ( 4 ) and *activated* p38 [mitogen activated protein kinases (MAPK)] and c-jun N-terminal kinase ( JNK ) . Positive_regulation MAPK13 TNF 15322069 1333421 We have also investigated the phosphorylation of p42/44 [MAPK] and *upregulation* of RhoA protein by . Positive_regulation MAPK13 TNF 15452110 1341992 In contrast , *induced* p42/p44 [MAPK] activation and CD54 expression remained unaltered . Positive_regulation MAPK13 TNF 15589482 1356212 In addition , luteolin inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , IkappaB degradation , and NF-kappaB activation . Positive_regulation MAPK13 TNF 15659876 1350306 The anabolic effect of was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an extracellular regulated kinases (ERK) . Positive_regulation MAPK13 TNF 15696169 1372160 Using TCPTP-deficient fibroblasts , we show here that TCPTP regulates *induced* [MAPK] but not NF-kappaB signaling . Positive_regulation MAPK13 TNF 15696169 1372201 These results link TCPTP and Src tyrosine kinases to the selective regulation of *induced* [MAPK] signaling and identify a previously unknown mechanism for modulating inflammatory responses mediated by TNF . Positive_regulation MAPK13 TNF 15703956 1497468 *Activation* of p38 [mitogen activated protein (MAP) kinase] and phosphatidylinositol 3-kinase (PI3K) by was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation MAPK13 TNF 15792609 1386794 By stimulation of in AM-1 cells , the phosphorylation of Akt ( Ser473 ) and p44/42 [mitogen activated protein kinase (MAPK)] ( Thr202/Tyr204 ) was markedly *increased* in TNFalpha concentration and time dependent manner . Positive_regulation MAPK13 TNF 15792609 1386807 Pretreatment with U0126 , mitogen activated extracellular regulated kinase ( MEK) 1/2 inhibitor , prior to TNFalpha stimulation , specifically inhibited *induced* phosphorylation of p44/42 [MAPK] ( Thr202/Tyr204 ) in AM-1 cells . Positive_regulation MAPK13 TNF 15792609 1386823 Meanwhile , pretreatment with LY294002 , phosphatidylinositol-3-OH kinase (PI3K) inhibitor , could inhibit both *induced* phosphorylation of Akt ( Ser473 ) and p44/42 [MAPK] ( Thr202/Tyr204 ) . Positive_regulation MAPK13 TNF 15823554 1393912 Furthermore , potently *activated* p38 [MAPK] , JNK , and NF-kappaB . Positive_regulation MAPK13 TNF 15837794 1432549 Expression of this protein inhibited induced *activation* of NFkappaB , JNK , and p38 [MAPK] and sensitized the cells to TNF induced apoptosis . Positive_regulation MAPK13 TNF 15845648 1425547 *induces* a more than tenfold increase in p38 [mitogen activated protein kinase (MAPK)] but not extracellular signal regulated kinase phosphorylation . Positive_regulation MAPK13 TNF 15870903 1405547 In addition , GA inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , I kappa B alpha degradation , and NF-kappa B activation . Positive_regulation MAPK13 TNF 16009485 1441403 Moreover , p44/42 [mitogen activated protein kinase] appears to partly *mediate* the negative effect of insulin but not on ATGL . Positive_regulation MAPK13 TNF 16023081 1441588 Ellagic acid inhibited IL-1beta- and induced *activation* of activator protein-1 and mitogen activated protein kinases ( extracellular signal regulated kinase , c-Jun N-terminal kinase and p38 [mitogen activated protein kinase] ) , but not of nuclear factor-kappaB . Positive_regulation MAPK13 TNF 16025396 1435611 *activated* the phosphorylation of p44/42 MAPK , p38 [MAPK] , SAPK/JNK and Akt in mesangial cells . Positive_regulation MAPK13 TNF 16025396 1435627 PGE1 inhibited the *induced* phosphorylation of SAPK/JNK and Akt , but not p44/42 MAPK and p38 [MAPK] . Positive_regulation MAPK13 TNF 16080915 1442767 Comparative gene array analysis of *induced* [MAPK] and NF-kappaB signaling pathways between retinal ganglion cells and glial cells . Positive_regulation MAPK13 TNF 16140562 1499253 These results suggested that TNFalpha induced both cell survival and apoptosis pathways in ameloblastoma and potential of TNFalpha in inducing apoptosis can be improved by inhibiting *induced* Akt and p44/42 [mitogen activated protein kinase (MAPK)] cell survival pathways . Positive_regulation MAPK13 TNF 16275991 1480300 Angiotensin II , , or epidermal growth factor *induced* [MAPK] phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation MAPK13 TNF 16291729 1526070 *Activation* of [MAPK] and Akt by anti-HER2/neu inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation MAPK13 TNF 16314440 1486999 treatment *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation in NPCs , and SB202190 , an inhibitor of p38 MAPK , blocked TNF-alpha induced chemokine production . Positive_regulation MAPK13 TNF 16325162 1511664 Furthermore , APE1/ref-1 overexpression inhibited the *induced* increase in intracellular superoxide and p38 [MAPK] phosphorylation . Positive_regulation MAPK13 TNF 16452991 1611736 Western blots showed that IL-1beta and *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK13 TNF 16517732 1530936 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of , but not IL-6 , *requires* the activity of p38 [MAPK] . Positive_regulation MAPK13 TNF 16573652 1556136 HA-mediated production *required* p38 [MAPK] , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation MAPK13 TNF 16682409 1584057 Further , the deletion of NQO1 abolished *induced* c-Jun N-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] activation . Positive_regulation MAPK13 TNF 16781693 1585615 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and and the *activation* of [MAPK] 's are potentially positive signals for IL-10 production . Positive_regulation MAPK13 TNF 16798728 1638534 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Positive_regulation MAPK13 TNF 16875982 1593562 *activates* [p38-MAPK] , a stress-responsive kinase implicated in contractile depression and cardiac injury . Positive_regulation MAPK13 TNF 16875982 1593576 Under conditions of constant coronary flow , the [p38-MAPK] activation and contractile depression *induced* by , though attenuated , remained sensitive to the absence of MKK3 or the presence of SB203580 . Positive_regulation MAPK13 TNF 16875982 1593590 *activates* [p38-MAPK] in the intact heart and in isolated cardiac myocytes through MKK3 . Positive_regulation MAPK13 TNF 16982923 1617362 Compared with wild-type cells , MIF-deficient cells were hyporesponsive to IL-1- and *induced* [MAPK] activity , AP-1 activity , and cellular proliferation , while NF-kappaB function was preserved . Positive_regulation MAPK13 TNF 17070777 1649832 Inhibition of Syk down-regulated *induced* p38 and p44/42 [MAPK] phosphorylation and nuclear translocation of p65 NF-kappaB . Positive_regulation MAPK13 TNF 17099067 1676200 Importantly , Dex is able to increase the expression of MKP-1 , which causes an inactivation of *induced* p38 [MAPK] and mediates inhibition of E-selectin expression . Positive_regulation MAPK13 TNF 17126899 1677673 Stimulation of ECs with *induced* rapid increases in the phosphorylation of their mitogen activated protein kinases ( MAPKs ) [ extracellular signal regulated kinase ( ERK ) , c-Jun-NH2-terminal kinase (JNK) , and p38 [MAPK] ] ; Positive_regulation MAPK13 TNF 17126905 1686547 Differential regulation of and GM-CSF *induced* activation of P38 [MAPK] in neutrophils and eosinophils . Positive_regulation MAPK13 TNF 17138860 1653546 The role of delta-PKC in *mediated* activation of [MAPK] is not known . Positive_regulation MAPK13 TNF 17138860 1653572 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 MAPK are involved in TNF antiapoptotic signaling and whether delta-PKC is a key regulator of [MAPK] *activation* by . Positive_regulation MAPK13 TNF 17138860 1653598 In human neutrophils , *activated* both p38 [MAPK] and ERK1/2 principally via TNFR-1 . Positive_regulation MAPK13 TNF 17158449 1694254 A green fluorescent protein fusion protein containing the last 100 residues of TAK1 ( TAK1-C100 ) abolished the interaction of endogenous TAB2/TAB3 with TAK1 , the phosphorylation of TAK1 , and prevented the activation of IKK and [MAPK] *induced* by IL-1 , , and RANKL . Positive_regulation MAPK13 TNF 17161959 1694538 Upon examination of the signaling components , we found that was a potent *activator* of p38 , p44/42 , p54/46 [MAPK] , and IkappaBalpha ( IkappaBalpha ) . Positive_regulation MAPK13 TNF 17172975 1679386 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the [MAPK] , and production of . Positive_regulation MAPK13 TNF 17172975 1679412 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the [MAPK] , and production of . Positive_regulation MAPK13 TNF 17189827 1680165 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Positive_regulation MAPK13 TNF 17202326 1680814 Augmented lipopolysaccharide induced production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK13 TNF 17202326 1680840 In this study , we show that augmented LPS induced production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK13 TNF 17218473 1732515 The RhoA inhibitor C3 exoenzyme and the ROCK inhibitor Y-27632 both attenuated induced [MAPK] *activation* and blocked AR expression in HIMEC . Positive_regulation MAPK13 TNF 17220297 1703053 TRAF2 and ASK1 play essential roles in *induced* [mitogen activated protein kinase] signaling . Positive_regulation MAPK13 TNF 17258890 1725452 The effects of and FasL on GrB expression were specifically *mediated* by [p38MAPK] ( Mitogen-activated-protein-kinase ) activation . Positive_regulation MAPK13 TNF 17425653 1748783 The percentage increases in IL-18 induced phosphorylation of extracellular signal regulated kinase ( ERK ) in Th cells of NDN and DN were significantly higher than controls ( P < 0.05 ) , while the percentage increase in *induced* phosphorylation of p38 [MAPK] in monocytes and IL-18 induced phosphorylation of p38 MAPK in Th cells and monocytes were significantly higher in NDN patients than controls . Positive_regulation MAPK13 TNF 17438131 1742773 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation MAPK13 TNF 17438336 1749075 FAK promoted *stimulated* [MAPK] activation needed for maximal IL-6 production . Positive_regulation MAPK13 TNF 17438336 1749095 Analysis of FAK ( -/- ) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity , Tyr-397 phosphorylation , and the Pro-712/713 proline-rich region of FAK were required for *stimulated* [MAPK] activation and IL-6 production . Positive_regulation MAPK13 TNF 17446186 1749510 *increased* p38 [MAPK] phosphorylation , potently stimulated IRS-1 serine phosphorylation , and blunted insulin stimulated IRS-1 tyrosine and Akt phosphorylation and eNOS activity . Positive_regulation MAPK13 TNF 17531219 1762170 On the other hand , aloe emodin did not affect *induced* activation of p38 [mitogen activated protein kinase] or generation of reactive oxygen species . Positive_regulation MAPK13 TNF 17607712 1798189 Although *induced* the activation of p38 [MAPK] , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation MAPK13 TNF 17725582 1801634 MAC inhibited induced p38 [mitogen activated protein kinase] *activation* and cell death in cultured Schwann cells . Positive_regulation MAPK13 TNF 17895408 1823965 IA did not interfere with induced *activation* of c-Jun N-terminal kinase (JNK) and p38 [mitogen activated protein kinase] . Positive_regulation MAPK13 TNF 17942934 1814214 Deletion of NQO2 also abolished induced c-Jun NH2-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] *activation* . Positive_regulation MAPK13 TNF 17994109 1851162 triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 [MAPK] , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation MAPK13 TNF 18039275 1828528 Further downstream in this axis of signalling , blockade *reduces* only acute bronchoconstriction , while [MAPK] inhibition abrogates completely endotoxin induced inflammation . Positive_regulation MAPK13 TNF 18060043 1853602 In cultures of Schwann cells , astrocytes , and microglia , sLRP-alpha inhibited *induced* activation of p38 [MAPK] and ERK/MAPK . Positive_regulation MAPK13 TNF 18061162 1861516 We demonstrate that *induced* proliferation of C4HD murine mammary tumor cells and of T47D cells through the activation of p42/p44 [MAPK] , JNK , PI3-K/Akt pathways and nuclear factor-kappa B (NF-kappa B) transcriptional activation . Positive_regulation MAPK13 TNF 18091748 1847367 *induced* phosphorylation of extracellular signal regulated kinase ( ERK ) and Akt , but not p38 [mitogen activated protein kinase (MAPK)] , was attenuated by nicardipine , cilnidipine , benidipine , efonidipine , and azelnidipine . Positive_regulation MAPK13 TNF 18227157 1884364 It was shown that these three proteins could ( i ) induce expression of and tissue factor and ( ii ) *induce* phosphorylation of p44/42 [mitogen activated protein kinases (MAPK)] and activation of early growth response factor 1 (Egr-1) . Positive_regulation MAPK13 TNF 18258304 1884796 However , over-expression of a dominant negative form of Rac strongly inhibited *induced* p42/44 [MAPK] kinase activation , but had little effect upon JNK and no effect upon p38 MAPK activity . Positive_regulation MAPK13 TNF 18287053 1872489 Here , we show that the murine CMV M45 protein binds to RIP1 and inhibits induced *activation* of NF-kappaB , p38 [MAPK] , and caspase independent cell death . Positive_regulation MAPK13 TNF 18287248 1896525 Flavopiridol suppresses *induced* activation of activator protein-1 , c-Jun N-terminal kinase , p38 [mitogen activated protein kinase (MAPK)] , p44/p42 MAPK , and Akt , inhibits expression of antiapoptotic gene products , and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells . Positive_regulation MAPK13 TNF 18314542 1931906 P < 0.05 ) , and MKP-1 up-regulation was temporally related to the inhibition of *induced* p38 [MAPK] phosphorylation . Positive_regulation MAPK13 TNF 18336852 1912240 *stimulated* phosphorylation of p42/p44 [MAPK] and JNK were attenuated by pretreatment with the inhibitors U0126 and SP600125 or transfection with dominant negative mutants of DeltaERK and DeltaJNK . Positive_regulation MAPK13 TNF 18364436 1912768 We , for the first time , demonstrate that binding of staphylococcal enterotoxin B to MHC-II results in activation of TNF-alpha converting enzyme , epidermal growth factor receptor , [p38MAPK] , and NF-kappaB *inducing* biphasic production . Positive_regulation MAPK13 TNF 18443205 1938526 Conversely , *induced* increases in insulin receptor substrate-1 serine phosphorylation ( Ser ( 312 ) ) , Jun NH ( 2 ) -terminal kinase phosphorylation , and extracellular signal related kinase-1/2 [mitogen activated protein kinase (MAPK)] phosphorylation were unaltered by siRNA mediated IKKbeta reduction . Positive_regulation MAPK13 TNF 18518937 1971920 Although Cot/Tpl2 was phosphorylated in IRI and in the cultured tubular epithelial cells (TEC) after stimulation with LPS and hydrogen peroxide , there were no significant differences in terms of production , neutrophil infiltration or [MAPK] *activation* between Cot/Tpl2 ( +/+ ) and Cot/Tpl2 ( -/- ) mice . Positive_regulation MAPK13 TNF 18636175 1937270 Furthermore , glucosamine inhibited the *induced* phosphorylation of [p38MAPK] and NF-kappaB p65 , and the nuclear translocation of NF-kappaB in the cells . Positive_regulation MAPK13 TNF 18653803 1960517 PMA stimulated nSMase2 translocation was independent of p38 MAPK , and neither PKC inhibitors nor small interfering RNA had significant effects on *stimulated* p38 [MAPK] activation , indicating that PKC-delta does not act through p38 MAPK in regulating nSMase2 . Positive_regulation MAPK13 TNF 18710428 2028201 As for the signalling pathway , stimulation *led* to the phosphorylation of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and translocation of nuclear factor kappaB (NF-kappaB) ( p65 ) into the nuclei . Positive_regulation MAPK13 TNF 18710428 2028223 These data suggest that interaction *leads* to the phosphorylation of Erk1/2 and [p38MAPK] and nuclear translocation of NF-kappaB , which is closely associated with the production and activation of MMP-9 in cultured CC cells of HuCTT-1 and CCKS-1 . Positive_regulation MAPK13 TNF 18768892 1957219 Consistently , Nod2-null macrophages tolerant to LPS and MDP showed enhanced production of and IL-6 as well as increased NF-kappaB and [MAPK] *activation* in response to the dipeptide KF1B , the Nod1 agonist . Positive_regulation MAPK13 TNF 18948845 2053240 Hypertonic saline did not alter *induced* p38 [mitogen activated protein kinase] phosphorylation or constitutive vascular endothelial growth factor expression , suggesting that the observed inhibition is not a generalized suppression of protein phosphorylation or cellular function . Positive_regulation MAPK13 TNF 19100731 2031221 at 30 ng/ml significantly *increased* phosphorylation of receptor tyrosine kinase ( 175 kDa ) and p42 [mitogen activated protein (MAP) kinase] . Positive_regulation MAPK13 TNF 19130554 2025300 Stimulation of HIMEC with *triggered* phosphorylation of the [MAPK] , and up-regulation of VCAM-1 , FKN and ICAM-1 . Positive_regulation MAPK13 TNF 19234337 2079510 Analysis of downstream signals showed that inhibition of NAD(P)H oxidase partially inhibited NF-kappaB activation but did not reduce CCL2 mRNA stability or prevent *induced* phosphorylation of [p38MAPK] . Positive_regulation MAPK13 TNF 19275968 2072844 *stimulated* the phosphorylation levels of p38 [MAPK] , JNK , ERK1/2 and Akt in vascular endothelial cells . Positive_regulation MAPK13 TNF 19289468 2073038 The requirement for MADD was highly specific for induced *activation* of [MAPK] but not the related JNK and p38 kinases . Positive_regulation MAPK13 TNF 19371952 2081762 Of note , the IFN-gamma plus *stimulated* activation of p38 [MAPK] was suppressed following incubation with forskolin or DBcAMP alone . Positive_regulation MAPK13 TNF 19410630 2089695 By transfection of TAK1 siRNA , *induced* phosphorylation of IkappaBalpha , JNK1/2 , and [p38MAPK] , as well as IL-6 or IL-8 expression , were repressed . Positive_regulation MAPK13 TNF 19427347 2106794 *induced* the phosphorylation of p38 [mitogen activated protein (MAP) kinase] , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation MAPK13 TNF 19429670 2106863 Ang II and clearly *enhanced* ERK and [p38MAPK] phosphorylation . Positive_regulation MAPK13 TNF 19563733 2122008 Finally , EZS inhibited *induced* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phosphorylation . Positive_regulation MAPK13 TNF 19648110 2138331 This correlates with reduced *stimulated* p38 [MAPK] phosphorylation . Positive_regulation MAPK13 TNF 19648110 2138346 Repression of *induced* p38 [MAPK] phosphorylation , NF-kappaB dependent transcription , and IL-8 expression by dexamethasone are sensitive to transcriptional or translational inhibitors . Positive_regulation MAPK13 TNF 19648110 2138417 Thus , MKP-1 attenuates dependent *activation* of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Positive_regulation MAPK13 TNF 19648110 2138444 Small interfering RNA knockdown of dexamethasone induced MKP-1 expression partially reverses the repression of *activated* p38 [MAPK] , demonstrating that MKP-1 participates in the dexamethasone dependent repression of this pathway . Positive_regulation MAPK13 TNF 19788916 2163922 ( TNF-alpha ) and H ( 2 ) O ( 2 ) *activate* [mitogen activated protein kinase (MAPK)] in SH-SY5Y cells within 5 min and this activation is completely blocked by DLPC ( 12 microM ) . Positive_regulation MAPK13 TNF 19877072 2160711 CpdA also displayed profound effects on induced [MAPK] *activation* . Positive_regulation MAPK13 TNF 19877072 2160728 In sharp contrast , DEX did not affect *induced* IKK phosphorylation , IkappaBalpha degradation , p65 nuclear translocation , or [MAPK] activation in RA FLS . Positive_regulation MAPK13 TNF 19889458 2197303 Calpain inhibition induces random migration in TNF-alpha stimulated cells and prevents the generation of reactive oxygen species , but does not alter *mediated* activation of p38 [MAPK] and ERK MAPK . Positive_regulation MAPK13 TNF 20231691 2237858 TNF-alpha treatment resulted in the phosphorylation of p38 MAPK and its downstream target , MAPK activated protein kinase-2 , but IFN-gamma did not affect the levels of [MAPK] and MAPK activated protein kinase-2 phosphorylation *induced* by . Positive_regulation MAPK13 TNF 20489729 2327420 induced *activation* of p38 [MAPK] and the production of inducible nitric oxide synthase were suppressed in ASK1-deficient Müller glial cells . Positive_regulation MAPK13 TNF 20646342 2292549 Effects of budesonide on P38 [MAPK] activation , apoptosis and IL-8 secretion , *induced* by and Haemophilus influenzae in human bronchial epithelial cells . Positive_regulation MAPK13 TNF 20646342 2292577 *induced* a significant increase in p38 [MAPK] phosphorylation . Positive_regulation MAPK13 TNF 20693316 2351478 In four of the six donors , basal and *induced* ERK and p38 [MAPK] activation were higher in ASMA than ASMNA cells . Positive_regulation MAPK13 TNF 20696856 2351509 Surprisingly , replenishment with exogenous GSH normalizes both *dependent* NF-?B as well as [MAPK] signaling and rescues hepatocytes from FKB induced death . Positive_regulation MAPK13 TNF 20951126 2364956 Taken together , this study provided first evidence demonstrating that TRAIL- , , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK13 TNF 21123734 2377722 The ability of CO to inhibit *induced* ERK1/2 and p38 [MAPK] activities in an Akt dependent manner appears to be the key element in ROS dependent survival of endothelial cells during TNF-a mediated brain inflammatory disease . Positive_regulation MAPK13 TNF 21181166 2499609 IL-1ß and *activated* the intracellular mitogen activated protein kinases ( MAPKs ) : p44/42 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) as well as nuclear factor-?B ( NF-?B ) in osteoblasts . Positive_regulation MAPK13 TNF 21285293 2425724 Inhibitors of NADPH oxidase and/or p47phox siRNA diminished ROS production and COX-2 expression as well as phosphorylation of p38 [mitogen activated protein kinase] ( p38MAPK ) and Akt *mediated* either by AS serum or by . Positive_regulation MAPK13 TNF 21336587 2457989 Effects of preconditioning with sevoflurane on induced permeability and *activation* of p38 [MAPK] in rat pulmonary microvascular endothelial cells . Positive_regulation MAPK13 TNF 21422246 2416768 Interestingly , all PHA-L ( high ) DCs displayed a strongly reduced responsiveness to *induced* [p38-MAPK] activation compared with PHA-L ( low ) DCs , indicating differences in PHA-L binding capacities between DCs with different inflammatory properties . Positive_regulation MAPK13 TNF 21422246 2416782 Moreover , hybrid-type , but not complex-type , N-glycans are required for *induced* [p38-MAPK] activation and subsequent phenotypic maturation of BMDCs ( MHC-II , CD86 , CCR7 upregulation ) . Positive_regulation MAPK13 TNF 21520062 2423121 Here , we report that *induced* cPLA(2) protein and mRNA expression , PGE ( 2 ) production , and phosphorylation of p42/p44 MAPK , p38 [MAPK] , and JNK1/2 , which were attenuated by pretreatment with a ROS scavenger [ N-acetyl-L-cysteine , ( NAC ) ] and the inhibitors of NADPH oxidase [ apocynin (APO) and diphenyleneiodonium chloride ( DPI ) ] , MEK1/2 ( U0126 ) , p38 MAPK ( SB202190 ) , and JNK1/2 ( SP600125 ) or transfection with siRNA of Nox2 , p47(phox) , MEK1 , p42 , p38 , or JNK2 . Positive_regulation MAPK13 TNF 21545687 2554380 significantly *induced* phosphorylation of p38 [MAPK] , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation MAPK13 TNF 21894146 2510870 Vehicle and untreated NTN exhibited heavy proteinuria and glomerular thrombosis at 24 h with P-selectin and fibrin immunostaining within capillaries , glomerular macrophage and T cell infiltration , *activation* of JNK and p38 [MAPK] signalling , and upregulation of glomerular mRNA levels of pro-inflammatory molecules ( , NOS2 , MMP-12 and CCL2 ) . Positive_regulation MAPK13 TNF 22002864 2526327 These results suggest that H ( 2 ) O ( 2 ) -induced secretion of *increases* apoptosis of cardiac myocytes through ROS dependent activation of p38 [MAPK] . Positive_regulation MAPK13 TNF 22227193 2544576 Casuarinin significantly inhibited induced *activation* of NF-?B , STAT1 , and p38 [MAPK] . Positive_regulation MAPK13 TNF 22230399 2519476 KMUP-1 inhibited *induced* iNOS and U46619 induced PDE-5A and phospho-p38 [MAPK] in normoxia , confirming its anti-proinflammatory action . Positive_regulation MAPK13 TNF 22250084 2551211 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Positive_regulation MAPK13 TNF 22343222 2617814 Using immunohistological techniques , we showed a higher epithelial expression of , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator [protein-1/mitogen activated protein kinase] signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation MAPK13 TNF 22525504 2522572 *up-regulated* the phosphorylation levels of p38 [MAPK] and increased the translocation of NF-kB p65 protein into the nucleus , also proved by immunofluorescence staining . Positive_regulation MAPK13 TNF 22526394 2595913 also *increased* the production of inducible nitric oxide synthase (iNOS) , nitric oxide ( NO ) , and intercellular adhesion molecule 1 ( ICAM-1 ) through activation of p38 [mitogen activated protein kinase (MAPK)] from HT-29 cells . Positive_regulation MAPK13 TNF 22773691 2659902 induced *activation* of p38 [MAPK] and NF-?B was attenuated by miR-140-3p mimic . Positive_regulation MAPK13 TNF 22819264 2646095 CORM-2 inhibited induced *activation* of p38 [MAPK] , ERK1/2 , JNK , and NF-?B signaling pathways in HUVECs . Positive_regulation MAPK13 TNF 22947346 2678661 *induced* phosphorylated p38 [mitogen activated protein kinase] levels were increased in ASMCs from patients with severe asthma compared with those from patients with nonsevere asthma and nonasthmatic subjects , whereas TNF-a induced phosphorylated c-Jun N-terminal kinase and phosphorylated extracellular signal related kinase levels were increased in all asthmatic groups . Positive_regulation MAPK13 TNF 22988345 2674355 The EGF receptor and HER2 participate in dependent [MAPK] *activation* and IL-8 secretion in intestinal epithelial cells . Positive_regulation MAPK13 TNF 22988345 2674383 As the epidermal growth factor receptor (EGFR) is a known transducer of proliferative signals and a potent activator of MAPKs , we hypothesized that the EGFR participates in dependent [MAPK] *activation* and IL-8 secretion by intestinal epithelial cells ( IECs ) . Positive_regulation MAPK13 TNF 23071098 2720905 Mixed-effects modeling analysis of our data was vital for ascertaining that IL-1a and TGF-a treatment increased the activities of more pathways than IL-6 and TNF-a and that TGF-a and *increased* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phospho-protein levels in a synergistic manner . Positive_regulation MAPK13 TNF 23142559 2722786 Western blot analysis revealed that pilocarpine and physostigmine enhanced the *induced* phosphorylation of ERK1/2 and p38 [MAPK] and the degradation of I?Ba . Positive_regulation MAPK13 TNF 23333920 2758384 Interestingly , IL-27 promoted the basal and enhanced *induced* phosphorylation of p38 [MAPK] and Akt , but not I?Ba . Positive_regulation MAPK13 TNF 23353699 2754240 We further demonstrated that markedly *stimulated* p38 [MAPK] , p42/p44 MAPK , and JNK1/2 phosphorylation via a c-Src/EGFR , PDGFR/PI3K/Akt pathway . Positive_regulation MAPK13 TNF 23354775 2770443 p38a [mitogen activated protein kinases (MAPK)] may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , , interleukin-1ß , and oxidative stress . Positive_regulation MAPK13 TNF 23664593 2838383 sFGL2 secretion by CD4 ( + ) T cells can be *induced* with and IFN-? stimulation through [MAPK] signaling in renal allograft AR . Positive_regulation MAPK13 TNF 23861542 2817227 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Positive_regulation MAPK13 TNF 23884101 2821468 Furthermore , P. vulgaris extract suppressed *induced* phosphorylation of p38 [mitogen activated protein kinase (MAPK)] and extracellular signal regulated kinase ( ERK ) . Positive_regulation MAPK13 TNF 23935096 2840765 In contrast , loss of SK1 prevented *induced* phosphorylation of p38 [MAPK] , and inhibition of p38 MAPK , like SK1 knockdown , also potentiates RANTES induction . Positive_regulation MAPK13 TNF 24069158 2846993 We showed that markedly *stimulated* p42/p44 MAPK , p38 [MAPK] , and JNK1/2 phosphorylation which were attenuated by their respective inhibitors . Positive_regulation MAPK13 TNF 24080497 2902539 Consistently , DUSP1 promotes apoptosis and decreases NF-?B activity in cells in which p38 [MAPK] is *induced* by treatment . Positive_regulation MAPK13 TNF 24089494 2848150 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed receptor 1 and *requires* activation of p38 [MAPK] , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation MAPK13 TNF 24361597 2911245 We further demonstrated that *stimulated* ERK1/2 , p38 [MAPK] , and JNK1/2 phosphorylation via a c-Src dependent PDGFR/PI3K/Akt pathway . Positive_regulation MAPK13 TNF 24378531 2911773 TRAF2 has been previously reported to be required for induced *activation* of p38 [MAPK] . Positive_regulation MAPK13 TNF 24441870 2922933 We showed that markedly *stimulated* Jak2 , PDGFR , Akt , and p42/p44 [MAPK] phosphorylation , which were attenuated by their respective inhibitors . Positive_regulation MAPK13 TNF 24441870 2922951 In addition , *induced* p42/p44 [MAPK] phosphorylation was reduced by AG1296 or LY294002 . Positive_regulation MAPK13 TNF 24441870 2922987 On the other hand , could *induce* Akt and p42/p44 [MAPK] translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation MAPK13 TNF 24446489 2912938 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Positive_regulation MAPK13 TNF 24489443 2884792 Finally , by investigating the intracellular pathways involved in promoting the VEC release of cytokines/chemokines , which are targeted by natural anti-inflammatory compounds , we documented that aLipoic acid significantly counteracted *induced* NF-?B and [p38/MAPK] activation while the effects of Ginkgo biloba appeared to be predominantly mediated by Akt . Positive_regulation MAPK13 TNF 24750790 2936569 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas and NO production *required* all three [MAPK] . Positive_regulation MAPK13 TNF 7689564 225764 *induced* activation and increased tyrosine phosphorylation of [mitogen activated protein (MAP) kinase] in human fibroblasts . Positive_regulation MAPK13 TNF 7689564 225777 induced *activation* of [MAPK] was demonstrated by its enhanced ability to phosphorylate myelin basic protein in vitro and by a characteristic shift in the electrophoretic mobility of MAPK proteins . Positive_regulation MAPK13 TNF 7722327 301757 *induces* tyrosine phosphorylation of [mitogen activated protein kinase] in adherent human neutrophils . Positive_regulation MAPK13 TNF 7722327 301783 PMN pretreatment with genistein , a tyrosine kinase inhibitor , inhibited the *induced* increase in tyrosine phosphorylation and [MAPK] activity . Positive_regulation MAPK13 TNF 8626494 360276 Inhibition of *induced* p42/p44 [mitogen activated protein kinase] activation by sodium salicylate . Positive_regulation MAPK13 TNF 8626494 360290 *activates* both p42 and p44 [mitogen activated protein kinases (MAPK)] in human FS-4 fibroblasts , cells for which TNF is mitogenic . Positive_regulation MAPK13 TNF 8626494 360303 We now show that *activates* p42 [MAPK] in two cell lines whose growth is inhibited by TNF . Positive_regulation MAPK13 TNF 8626494 360318 We now show that neither phorbol ester-sensitive protein kinase C nor Gialpha link TNF to p42/p44 MAPK activation , because pretreatment of FS-4 cells with phorbol ester to down-regulate protein kinase C or pretreatment with pertussis toxin to block Gialpha does not inhibit p42/p44 [MAPK] *activation* by . Positive_regulation MAPK13 TNF 8626494 360340 To further analyze MAPK activation in FS-4 cells , we compared p42/p44 [MAPK] *activation* by and epidermal growth factor (EGF) . Positive_regulation MAPK13 TNF 8626494 360363 Elucidation of the mechanism whereby sodium salicylate blocks induced p42/p44 [MAPK] *activation* may help to clarify TNF activated signaling pathways . Positive_regulation MAPK13 TNF 8662702 367182 additionally *caused* rapid p38 and JNK-1 [mitogen activated protein kinase] activation and efficient NF-kappaB translocation , which could not be achieved even by high levels of ceramide . Positive_regulation MAPK13 TNF 9106254 424413 The increases in [MAPK] *induced* by and IL-1 were similar to the increases induced by PMA and PDGF-AB . Positive_regulation MAPK13 TNF 9106254 424439 Our findings indicate that and IL-1 activate parallel signal transduction pathways in human neuroma fibroblasts , and that they are relatively stronger *activators* of [MAPK] than of SAPK . Positive_regulation MAPK13 TNF 9315666 456100 , an inhibitor of insulin stimulated adipogenesis , *activated* [MAPK] in 3T3-L1 cells . Positive_regulation MAPK13 TNF 9439626 482869 *increased* ERK1 and ERK2 [MAPK] phosphorylation . Positive_regulation MAPK13 TNF 9439626 482895 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic effect of *requires* protein tyrosine phosphorylation and [MAPK] activation . Positive_regulation MAPK13 TNF 9593119 505485 The CAZ released endotoxin was similar to purified LPS with respect to the following biological activities in LPS-responsive C3H/HeN mice and LPS-hyporesponsive C3H/HeJ mice : lethal toxicity in GalN sensitized mice , in vitro induction of and NO production by macrophages , and [mitogen activated protein kinase] *activation* in macrophages . Positive_regulation MAPK13 TNF 9766635 538508 Our data suggest that and GM-CSF *activate* ERKs and p38 [MAPK] by different signal transduction pathways . Positive_regulation MAPK13 TNF 9770326 538802 Furthermore , *induction* of p42/p44 ERK and [p38-MAPK] phosphorylation , c-jun kinase activation , and IkappaBalpha degradation were normal . Positive_regulation MAPK13 TNF 9883899 558208 *Activation* of p42/p44 [mitogen activated protein kinases (MAPK)] and p38 MAPK by is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation MAPK13 TNF 9883899 558223 Here , we demonstrate that is *sufficient* to activate p42/p44 MAPK and p38 [MAPK] . Positive_regulation MAPK13 TNF 9930718 588837 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Positive_regulation MAPK13 TNF 9931102 588904 ( 100 U/mL ) transiently *activated* [MAPK] with a maximal induction 10 minutes after stimulation that returned to baseline levels by 2 hours after treatment . Positive_regulation MAPK13 TNF 9931102 588917 PD98059 also blocked *stimulated* [MAPK] activation in a concentration dependent manner , which is consistent with its inhibition of TNF-alpha directed migration . Positive_regulation MAPK13 TNF 9931102 588930 To identify which TNF-alpha receptor is involved in *induced* [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Positive_regulation MAPK13 TNF 9931102 588956 VSMC express both receptors , but *induced* [MAPK] activation was inhibited only by the TNF-R1 antibody . Positive_regulation MAPK13 TNF 9931102 588982 Both TRO and RSG inhibited migration , but neither attenuated induced [MAPK] *activation* , indicating that their antimigration activity was exerted downstream of MAPK . Positive_regulation MAPK13 TNFSF10 12969966 1185571 Among the intracellular pathways investigated , significantly *stimulated* the extracellular signal regulated kinase 1/2 ( ERK1/2 ) but not the [p38/mitogen activated protein kinase (MAPK)] or the c-Jun NH2-terminal kinase (JNK) pathway . Positive_regulation MAPK13 TNFSF10 20951126 2364957 Taken together , this study provided first evidence demonstrating that , TNF-a- , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK13 TNFSF10 21152872 2373393 Taken together , we show herein that the upstream molecule of the induced [MAPK] *activation* is MEKK , as opposed to ASK1 , via the mediation of its signal through JNK/p38 in a caspase-8 dependent manner . Positive_regulation MAPK14 ADRB2 11018034 752790 induced p38 [MAPK] *activation* is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes . Positive_regulation MAPK14 ADRB2 12509508 1038742 beta-Arrestin 1 is required for internalization and [mitogen activated protein (MAP) kinase] *activation* by the . Positive_regulation MAPK14 ADRB2 19047375 2023484 Hematopoietic protein tyrosine phosphatase mediates *induced* regulation of p38 [mitogen activated protein kinase] in B lymphocytes . Positive_regulation MAPK14 ADRB2 9038193 415365 In the present work , we report that stimulation of the A2A-adenosine receptor and of the *activates* [mitogen activated protein kinase] ( MAP kinase ) in human endothelial cells based on the following criteria : adenosine analogues and beta-adrenergic agonists cause an ( i ) increase in tyrosine phosphorylation of the p42 isoform and to a lesser extent of the p44 isoform of MAP kinase and ( ii ) stimulate the phosphorylation of myelin basic protein by MAP kinase; (iii) this is accompanied by a redistribution of the enzyme to the perinuclear region . Positive_regulation MAPK14 ADRB2 9363896 462908 We show that in HEK293 cells , *stimulation* of [mitogen activated protein (MAP) kinase] by the is mediated by the betagamma subunits of pertussis-toxin-sensitive G proteins through a pathway involving the non-receptor tyrosine kinase c-Src and the G protein Ras . Positive_regulation MAPK14 ALOX5 11807011 903508 In contrast , stress induced product formation and translocation of <5-LO> , as well as *activation* of p38 [MAPK] , occurred also after Ca ( ++ ) depletion . Positive_regulation MAPK14 ALOX5 21200133 2391688 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Positive_regulation MAPK14 ANGPT1 12039842 954281 Accordingly , ephrinB2 inhibited VEGF- and *induced* [Ras-MAPK] activities , whereas ephrinB2 did not alter VEGF induced Flk phosphorylation or Ang1 induced Tie2 phosphorylation . Positive_regulation MAPK14 ANGPT1 12213710 985643 Both VEGF and *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 [MAPK] . Positive_regulation MAPK14 ANGPT1 12213726 985713 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of and Ang-2 as well as the *activation* of [MAPK] , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation MAPK14 ANGPT1 16061664 1439069 *activated* [mitogen activated protein kinase (MAPK)] and phosphoinositide 3-kinase (PI3K) in IBE cells and HUVECs . Positive_regulation MAPK14 ANGPT1 16679392 1612153 Pretreatment with either DPI or apocynin also significantly attenuated *induced* Akt and p44/42 [MAPK] phosphorylation . Positive_regulation MAPK14 ANGPT1 16679392 1612169 Using mouse heart microvascular endothelial cells from wild-type ( WT ) mice and mice deficient in the p47(phox) component of NADPH oxidase ( p47 ( phox-/- ) ) , we found that although *stimulated* intracellular ROS , Akt and p42/44 [MAPK] phosphorylation , and cell migration in WT cells , the responses were strikingly suppressed in cells from the p47 ( phox-/- ) mice . Positive_regulation MAPK14 ANGPT1 20072135 2235287 *promoted* skin cell metabolism/viability , adhesion , and akt and [MAPK] ( p42/44 ) activations . Positive_regulation MAPK14 ANO1 22564524 2619162 *induces* [MAPK] and contributes directly to tumorigenesis and cancer progression . Positive_regulation MAPK14 CAPN8 21543591 2424117 Downstream , an Aß-mediated rise in p38 [mitogen activated protein kinase (MAPK)] activation was followed by downregulation of cAMP response element binding protein , and LTP impairment was *prevented* by inhibitors of p38 MAPK or . Positive_regulation MAPK14 CAPN8 24416390 2900985 Treatment with glutamate leads to early activation of NMDAR , which in turn leads to mediated cleavage of striatal enriched protein tyrosine phosphatase ( STEP ) and subsequent *activation* of p38 [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK14 CCL17 23711854 2792897 IL-33 induced the production of thymus and activation regulated and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 [MAPK] . Positive_regulation MAPK14 CCND1 11004713 735016 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping [ERK-MAPK] activation and c-Fos and *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation MAPK14 CCND1 12654183 1072984 [MAPK] may *induce* overexpression of protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation MAPK14 CCND1 15634644 1349554 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 [mitogen activated protein kinase] , and down-regulation of . Positive_regulation MAPK14 CCND1 16522728 1531458 We conclude that incretin induced beta-cell replication is dependent on cAMP/PKA , p42 [MAPK] and PI3K activities , which may *involve* transcriptional induction of . Positive_regulation MAPK14 CCND1 9537433 497560 Furthermore , in 25 of 26 cases of HCC which genomic DNA was available , 22 cases without genomic DNA amplification exhibited positive correlation , not only between protein expression of c-Fos and , but also between [MAPK/ERK] *activation* and cyclin D1 expression . Positive_regulation MAPK14 CD14 15625444 1349237 LPS interacts with the cell surface receptor , which generates transmembrane signals through Toll-like protein 4 *leading* to [mitogen activated protein kinase (MAPK)] p38 activation , cytokine synthesis , PMN beta2-integrin expression and oxidative burst . Positive_regulation MAPK14 CHI3L1 23755018 2797728 In addition , *induces* [FAK-MAPK] signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation MAPK14 CHI3L1 23972995 2836240 We also demonstrate that *activates* macrophage [mitogen activated protein kinase] , protein kinase B/AKT , and Wnt/ß-catenin signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation MAPK14 CLU 23051594 2702815 FOXL2 directly stimulates the Clu gene promoter , and we show that PTTG triggers ataxia telangiectasia mutated [kinase/IGF-I/p38MAPK] DNA damage/chromosomal instability signaling , which in turn also *induces* expression . Positive_regulation MAPK14 CTGF 11732999 885263 *induces* chondrocyte differentiation through a p38 [mitogen activated protein kinase] ( p38MAPK ) , and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase ( ERK ) . Positive_regulation MAPK14 CTGF 11732999 885277 In the proliferation phase , *induced* a approximately fivefold increase in the phosphorylation of p44/42 [MAPK/ERK] and a approximately twofold increase in that of p38 MAPK in an in vivo kinase assay . Positive_regulation MAPK14 CTGF 12218048 1012163 The inhibition of *induced* p42/44 [MAPK] or phosphatidylinositol 3-kinase (PI3K)/protein kinase B pathway activities abrogated the induction of fibronectin expression . Positive_regulation MAPK14 CTGF 16408113 1513478 *enhanced* the mRNA expression and protein release of fractalkine , MCP-1 , and RANTES , the expression of phospho ( P ) -p42/44 [mitogen activated protein kinase (MAPK)] , P-phosphoinositide 3-kinase (PI3-K) , P-Akt , and activity of nuclear factor-kappaB (NF-kappaB) in mesangial cells . Positive_regulation MAPK14 CTGF 16408113 1513508 P-p42/44 MAPK blockade inhibited the *induced* expression of P-p42/44 [MAPK] but not NF-kappaB , and partially decreased the levels of the above chemokines in supernatants . Positive_regulation MAPK14 CTGF 16522717 1531326 ( 3 ) *stimulated* dose dependent HSC adhesion and activity of p42/p44 [mitogen activated protein kinase] , the latter of which was antagonized by blocking the activity of focal adhesion kinase . Positive_regulation MAPK14 CTGF 16938382 1654125 No single module , but a mixture of the 4 modules provoked a significant activation of p38 [MAPK] in HCS-2/8 cells , which was *activated* by the full-length . Positive_regulation MAPK14 CTGF 19038999 2023085 Interestingly , CCN2-BMP-2 did not affect the *induced* phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Positive_regulation MAPK14 EDN2 12193071 980934 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Positive_regulation MAPK14 EDN2 12475899 1037772 *induced* a rapid phosphorylation of the [mitogen activated protein kinase (MAPK)/ERK] and increased collagen I gene activity in freshly isolated aortas . Positive_regulation MAPK14 EDN2 1280103 203039 rapidly *stimulates* [mitogen activated protein kinase] activity in rat mesangial cells . Positive_regulation MAPK14 EDN2 12855582 1149890 also *induced* the activation of p42/44 [mitogen activated protein kinase (MAPK)] in DCs . Positive_regulation MAPK14 EDN2 7509933 241606 *stimulates* [mitogen activated protein kinase] p42 activity through the phosphorylation of the kinase in rat mesangial cells . Positive_regulation MAPK14 EDN2 7849246 286730 *stimulates* [mitogen activated protein kinase] activity in mesangial cells through ETA . Positive_regulation MAPK14 EDN2 7943276 276397 has been shown to *activate* [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK14 EDN2 8836145 386171 In bovine airway smooth-muscle cells platelet derived growth factor ( PDGF ) and ( Et-1 ) *stimulate* sustained and comparable activation of [mitogen activated protein kinase] ( MAP kinase ) but display very different mitogenic efficacies , with PDGF inducing 50 times more DNA synthesis than Et-1 . Positive_regulation MAPK14 EFNB1 15502157 1347561 Further downstream of the signaling pathway , stimulation *led* to increased LAT ( linker for activation of T-cells ) phosphorylation and p44/42 and p38 [MAPK] activation . Positive_regulation MAPK14 EPHB2 10601128 574207 Tumor necrosis factor-alpha (TNF-alpha) alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only . Positive_regulation MAPK14 EPHB2 10872747 707026 Pre-treatment of the cells with PD98059 , a selective pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation MAPK14 EPHB2 11083274 750492 Tumor necrosis factor alpha , interleukin-1 (IL-1) , and IL-6 were the major inducers of , JNK , and p38 [MAPK] *activation* in cultured human synovial cells . Positive_regulation MAPK14 EPHB2 12386816 999764 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 [MAPK] and a biphasic *activation* of . Positive_regulation MAPK14 EPHB2 12403788 1036181 SB203580 , a p38 [MAPK] *inhibitor* , and PD98059 , an inhibitor , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation MAPK14 EPHB2 12486127 1056309 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain *had* little effect on basal Erk [MAPK] activation . Positive_regulation MAPK14 EPHB2 12511425 1070738 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation MAPK14 EPHB2 12801927 1120233 GE2 stimulation *induced* phosphorylation , whereas it did not alter the phosphorylation of c-Jun N-terminal kinase or p38 [MAPK] . Positive_regulation MAPK14 EPHB2 12832293 1105578 Exposure to E. coli DNA resulted in phosphorylation of ERK 1/2 [MAPK] and inhibitors of activity ( PD98059 , UO126 ) significantly *reduced* the evoked IL-8 production . Positive_regulation MAPK14 EPHB2 12878192 1115520 ( 2 ) the *activation* of JNK and p38 [MAPK] but not in embryonic fibroblasts ( MEFs ) derived from ASK1 knockout mice ( ASK1 ( -/- ) MEFs ) was depressed compared to MEFs derived from wild type mice ( ASK1 ( +/+ ) MEFs ) ; Positive_regulation MAPK14 EPHB2 14973553 1212639 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen activated protein kinase (MAPK)] signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation MAPK14 EPHB2 14998726 1216731 Furthermore , we found that PD98059 , an pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation MAPK14 EPHB2 15659876 1350309 The anabolic effect of TNF-alpha was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an . Positive_regulation MAPK14 EPHB2 16038626 1437419 SF significantly prevented Abeta induced increases in IL-1beta and p38 [MAPK] *activation* and also Abeta induced changes in and phospho-Akt/PKB expression levels . Positive_regulation MAPK14 EPHB2 17056059 1649528 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Positive_regulation MAPK14 EPHB2 17403539 1735935 Trauma-hemorrhage increased the production of IL-6 , IL-10 , IL-12 and TNF-alpha enhanced the expression of TLR4 , MyD88 as well as the *activation* of [MAPK] proteins ( p38 , and JNK ) in epidermal keratinocytes . Positive_regulation MAPK14 EPHB2 17416211 1777887 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK14 EPHB2 17464174 1731746 The mRNA and surface protein up-regulation of CCR1 and CCR2 in 9CRA stimulated cells were weakly blocked by the pretreatment of SB202190 , a p38 [MAPK] *inhibitor* , and PD98059 , an upstream inhibitor . Positive_regulation MAPK14 EPHB2 18164124 1869611 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 [MAPK] , but not by the *activation* of JNK , , and NF-kappaB pathway . Positive_regulation MAPK14 EPHB2 18266967 2000301 VEGF induced activation of p42 also *led* to the nuclear translocation of [MAPK/ERK1/2] . Positive_regulation MAPK14 EPHB2 18285354 1885407 Pre-treatment with the [MAPK] *inhibitors* SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( inhibitor ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation MAPK14 EPHB2 18338254 1938059 Interestingly , inhibition of by U0126 completely *prevented* artepillin C-induced p38 [MAPK] phosphorylation of PC12m3 cells . Positive_regulation MAPK14 EPHB2 18520049 1918674 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of , rather than by the *activation* of p38 [MAPK] , in the spinal cord . Positive_regulation MAPK14 EPHB2 18982426 2105748 These inhibitory effects were partially inhibited by SB203580 , a specific *inhibitor* of p38 [MAPK] , but not by PD98059 , a specific inhibitors of extracellular signal regulated kinase ( ) , and SP600125 , a specific inhibitor of c-Jun-N-terminal kinase (JNK) . Positive_regulation MAPK14 EPHB2 19189219 2113963 Moreover , EM1 treatment resulted in less activation of p38 [MAPK] and more *activation* of signaling in lipopolysaccharide stimulated DCs . Positive_regulation MAPK14 EPHB2 19276187 2051419 Treatment of cells with sphingosine induced suppression of and *activation* of p38 [MAPK] . Positive_regulation MAPK14 EPHB2 19429670 2106922 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either inhibitor , [p38MAPK] *inhibitor* or NF-kappaB inhibitor . Positive_regulation MAPK14 EPHB2 19522739 2103142 Treatment with [MAPK] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation MAPK14 EPHB2 19672126 2168069 A scratch wound assay of healing rates in SV40 immortalized human corneal epithelial cell line ( HCEC ) evaluated the relative contributions by p38 and and JNK [MAPK] signaling *activation* to wound healing . Positive_regulation MAPK14 EPHB2 20025124 2175514 Prior treatment of the cells with PD98059 , an kinase inhibitor or SB203580 , a [p38MAPK] *inhibitor* , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation MAPK14 EPHB2 20554538 2327623 The HNE enhanced Sp1 and NF-?B activities were attenuated by SB203580 , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , and PD98059 , an extracellular signal regulated kinase ( ) inhibitor , respectively . Positive_regulation MAPK14 EPHB2 21126656 2355800 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 [mitogen activated protein kinase] , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by . Positive_regulation MAPK14 EPHB2 21311676 2360035 Treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation MAPK14 EPHB2 21488184 2417974 Dexmedetomidine induced phosphorylation of JNK and p38 [MAPK] in rat aortic SMCs , but did not *induce* phosphorylation of . Positive_regulation MAPK14 EPHB2 21586573 2449667 Incubation of T cells with ESAT-6 induced phosphorylation and increased functional p38 [MAPK] activity , but not *activation* of or JNK . Positive_regulation MAPK14 EPHB2 21599960 2445728 In the present studies , induction of central sensitization as indicated by spinal dorsal horn [MAPK] *activation* , specifically and p38 phosphorylation , was assessed in the MIA-OA model . Positive_regulation MAPK14 EPHB2 23394443 2713238 When compared to hamsters bearing tumors that remained on the control diet , the buccal pouches of hamsters bearing tumors receiving turmeric showed the following results : ( 1 ) decreased cell proliferation ( diminished PCNA , cyclin D1 , and Bcl-2 ) and PCNA labelling index , ( 2 ) enhanced apoptosis ( increased Bax , caspase-3 , caspase-9 , and cytochrome c , and decreased survivin ) and apoptotic index , ( 3 ) decreased inflammation ( decreased Cox-2 ) , and ( 4 ) decreased [MAPK] *activation* ( and p-p38 ) . Positive_regulation MAPK14 EPHB2 23892041 2830336 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three [MAPK] *inhibitors* ( inhibitor PD98059 , JNK inhibitor SP600125 and p38 inhibitor SB203580 ) . Positive_regulation MAPK14 EPHB2 23914844 2840572 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 [MAPK] and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of , JNK , NF-?B . Positive_regulation MAPK14 EPHB2 23917355 2826031 Inhibition of Akt or activity *reduced* phosphorylation of STAT1 in Colon26L5-CUG2 cells whereas inhibition of p38 [MAPK] did not significantly decrease levels of STAT1 phosphorylation , indicating that cell proliferation signals may be involved in CUG2 mediated activation of STAT1 . Positive_regulation MAPK14 EPHB2 24225419 2897496 Therefore , by using the [MAPK] *inhibitors* SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific inhibitor ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation MAPK14 EPHB2 24297112 2894221 Following treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation MAPK14 F2R 16052512 1460026 The p38 and ERK1/2 [MAPK] signaling cascades were also *activated* by stimulation , whereas the SAPK/JNK pathway was unaffected . Positive_regulation MAPK14 F2R 16467309 1548155 and PAR-2 stimulation rapidly *activated* both ERK1/2 and [p38MAPK] , and pharmacological blockade of MEK with either PD98059 or U0126 or of p38MAPK by SB203580 or SB202190 strongly inhibited thrombin- and SLIGKV induced COX-2 expression and 6-keto-PGF1alpha formation . Positive_regulation MAPK14 F2R 21252088 2402886 In the present study , we show that FVIIa , upon binding to EPCR on endothelial cells , activates endogenous protease activated receptor-1 (PAR1) and induces mediated p44/42 [mitogen activated protein kinase (MAPK)] *activation* . Positive_regulation MAPK14 F2R 24052258 2867017 However , the distinct non-canonical tethered ligands unmasked by neutrophil elastase and proteinase-3 , as well as synthetic peptides with sequences derived from these novel exposed tethered ligands , selectively stimulated mediated [mitogen activated protein kinase] *activation* . Positive_regulation MAPK14 F2R 8635212 357922 These results support the notion that the *activates* [MAPK] through PKC dependent pathways and that the incremental activation of MAPK by TRAP over that induced by thrombin is the consequence of enhanced activation through the PKC limb of the phosphoinositide lipid pathway . Positive_regulation MAPK14 FAS 14576831 1156606 A more physiological inhibitor , the intracellular PP2A inhibitor protein I2 ( PP2A ) , protected transfected HeLa cells in a similar way from *mediated* apoptosis and induced activation of [MAPK] in I2 ( PP2A ) transfected cells . Positive_regulation MAPK14 FAS 15280387 1302533 We further demonstrate that this pro-apoptotic effect of CO was independent of reactive oxygen species production and involved inhibition in *induced* activation of the pro-survival ERK [MAPK] . Positive_regulation MAPK14 FAS 16507991 1529637 Here we show that binding of Fas ligand to *activates* p38 [MAPK] in CD8+ T cells and that activation of this pathway is required for Fas mediated CD8+ T-cell death . Positive_regulation MAPK14 FAS 19417161 2179811 GST-MDA-7 killing was , in parallel , dependent on inactivation of extracellular signal regulated kinase 1/2 and on *induced* p38 [mitogen activated protein kinase] and c-jun NH ( 2 ) -terminal kinase-1/2 signaling . Positive_regulation MAPK14 FAS 21613257 2454277 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Positive_regulation MAPK14 FAS 21975294 2492844 Caspase-8 activity has an essential role in mediated [MAPK] *activation* . Positive_regulation MAPK14 FAS 8977313 403347 IFN-alpha2 did not alter the *induced* activity of [Mitogen activated protein kinase (MAPK)] 1 and did not inhibit the Apo-1/Fas mediated proteolytic cleavage of ADP-ribosyltransferase , a substrate of Interleukin-beta1 converting enzyme ( ICE ) and homologues . Positive_regulation MAPK14 FHL1 23456229 2781818 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Positive_regulation MAPK14 FOXA1 22879989 2641683 An increase in IGFBP-3 , mediated by depletion of , *inhibited* phosphorylation of [MAPK] and Akt , and increased expression of the cell cycle regulators p21 and p27 . Positive_regulation MAPK14 FUT4 20506505 2307956 These data suggested that not only *activates* [MAPK] and PI3K/Akt signals , but also promotes the crosstalk among these signaling pathways . Positive_regulation MAPK14 GLP1R 21356521 2394816 activation by Exendin-4 ( Ex-4 ) *increased* PKA and [MAPK] activity and decreased phosphorylation of AMPK in NTS . Positive_regulation MAPK14 GPR115 10958680 725516 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK14 GPR115 11916960 945268 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK14 GPR115 9182581 435462 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK14 GPR115 9826186 549859 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK14 GPR132 10958680 725505 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK14 GPR132 11474113 841739 Activation of by LPC *increased* intracellular calcium concentration , induced receptor internalization , activated ERK [mitogen activated protein kinase] , and modified migratory responses of Jurkat T lymphocytes . Positive_regulation MAPK14 GPR132 11916960 945257 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK14 GPR132 9182581 435451 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK14 GPR132 9826186 549848 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK14 GPR87 10958680 725585 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK14 GPR87 11916960 945337 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK14 GPR87 9182581 435531 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK14 GPR87 9826186 549928 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK14 HBEGF 10544013 563924 also rapidly *activated* [MAPK] and induced cyclin D1 in mid-G1 with kinetics similar to TGFalpha . Positive_regulation MAPK14 HBEGF 11171084 783795 Both p42 [MAPK] activation and mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation MAPK14 HBEGF 15380451 1298481 *induced* phosphorylation of ERK , p38 [MAPK] and Akt , which were suppressed by ZD1839 . Positive_regulation MAPK14 HBEGF 17928891 1858625 We report that cellular stress with methyl-beta-cyclodextrin ( MBCD ) , a molecule that extracts membrane cholesterol and thereby disrupts the structure of lipid rafts , strongly *induces* the synthesis of ( HB-EGF ) in keratinocytes through the activation of p38 [mitogen activated protein kinase] . Positive_regulation MAPK14 HBEGF 18990151 2028924 *Activation* of [Erk/MAPK] by was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation MAPK14 HBEGF 19048624 2023717 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked MAPK signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 [MAPK] , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Positive_regulation MAPK14 HBEGF 19559571 2110505 *induced* phosphorylation of p42/p44 [MAPK] in a few minutes . Positive_regulation MAPK14 HBEGF 20130271 2242161 Additionally , hypoxia *induces* an autocrine increase in protein levels through [MAPK14] , JNK or ERK . Positive_regulation MAPK14 HBEGF 20739666 2345890 Moreover , *induced* a stronger and more sustained activation of both the [mitogen activated protein kinase] and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation MAPK14 HBEGF 24188029 2921104 Here , we show that *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , [Mapk/Erk] pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation MAPK14 HRH1 11959800 931442 1. Previous studies have shown that the *activates* p42/p44 [mitogen activated protein kinases (MAPK)] in DDT ( 1 ) MF-2 smooth muscle cells via a phosphatidylinositol 3-kinase (PI-3K) dependent pathway . Positive_regulation MAPK14 HRH1 17965772 1820340 is *required* for TCR mediated p38 [MAPK] activation and optimal IFN-gamma production in mice . Positive_regulation MAPK14 HRH1 17965772 1820354 Moreover , signaling at the time of TCR ligation was *required* for activation of p38 [MAPK] , a known regulator of IFN-gamma expression . Positive_regulation MAPK14 IFI27 16953232 1682581 RET2A mediated regulation of p18 and , but not of cyclins D1 and D2 , *requires* functional [mitogen activated protein kinase] signaling . Positive_regulation MAPK14 IL1B 10640438 577506 and TNF alpha also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK14 IL1B 10704772 673006 CPI-1189 inhibits *induced* [p38-mitogen activated protein kinase] phosphorylation : an explanation for its neuroprotective properties ? Positive_regulation MAPK14 IL1B 10775561 686645 *activated* p44/42 [MAPK] , and this activation was enhanced in the presence of N-acetyl-L-cysteine . Positive_regulation MAPK14 IL1B 10864897 705728 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK14 IL1B 10864897 705780 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by TNF-alpha and . Positive_regulation MAPK14 IL1B 10864897 705799 TNF-alpha- and *induced* [ ( 3 ) H ] -thymidine incorporation and phosphorylation of p42/p44 [MAPK] was completely inhibited by PD98059 ( an inhibitor of MEK1/2 ) , indicating that activation of MEK1/2 was required for these responses . Positive_regulation MAPK14 IL1B 10969830 728487 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Positive_regulation MAPK14 IL1B 11032891 740455 *induces* p38 [MAPK] phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation MAPK14 IL1B 11037878 741242 also *stimulated* phosphorylation of p38 [MAPK] , SAPK/JNK , and ATF-2 . Positive_regulation MAPK14 IL1B 11126408 759774 TNFalpha and IFNgamma potentiate *induced* [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK14 IL1B 11126408 759787 [Mitogen activated protein kinase (MAPK)] activity that is *induced* by has been suggested to signal nitric oxide dependent as well as nitric oxide independent beta-cell destructive pathways . Positive_regulation MAPK14 IL1B 11126408 759800 The aim of this study was to investigate if TNFalpha and IFNgamma signal through mitogen activated protein kinases in isolated rat islets of Langerhans and if they potentiate [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK14 IL1B 11126408 759813 Further , TNFalpha and IFNgamma were found to synergistically increase [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK14 IL1B 11399523 824261 Glucose potentiates *induced* p38 [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK14 IL1B 11509550 848365 Although and TNF-alpha each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK14 IL1B 11557585 861404 *activated* the three [mitogen activated protein kinase] ( extracellular signal regulated kinases 1 and 2 , c-Jun NH2-terminal kinase/stress activated protein kinase , and p38 ) and the Janus kinase (JAK)-signal transducer and activator of transcription pathways . Positive_regulation MAPK14 IL1B 11698472 878053 *induced* phosphorylation and activation of p38 [MAPK] and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation MAPK14 IL1B 11698472 878099 *induced* phosphorylation of ERK and JNK as well as p38 [MAPK] in human endothelial cells . Positive_regulation MAPK14 IL1B 11728947 884810 We showed a dramatic decrease in *induced* phosphorylation of p38 [MAPK] , not extracellular signal regulated kinases 1/2 or jun NH2-terminal kinase , in rat cultured mesangial cells by FR167653 . Positive_regulation MAPK14 IL1B 11775830 766438 Role of protein tyrosine kinase in *induced* activation of [mitogen activated protein kinase] in fibroblast-like synoviocytes of rheumatoid arthritis . Positive_regulation MAPK14 IL1B 11853544 913372 Interestingly , *induced* p38 [MAPK] activity was greatly enhanced in ( alg+ ) compared with ( alg- ) cells . Positive_regulation MAPK14 IL1B 12117921 964666 mRNA expression by neutrophils was not dependent on p38 MAPK , and p38 [MAPK] was not *activated* in neutrophils incubated with A. phagocytophila . Positive_regulation MAPK14 IL1B 12131776 966861 and TNF-alpha *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK14 IL1B 12139924 969397 Regarding intracellular signaling , *activated* the p38 mitogen activated protein kinase (MAPK) but not the p42/p44 [MAPK] and , when combined with growth factors , intensified p38 activation but inhibited the growth-factor induced p42/p44 activation . Positive_regulation MAPK14 IL1B 12356282 993858 induced p44/42 [mitogen activated protein kinase (MAPK)] *activation* was inhibited by the MAPK/extracellular signal regulated protein kinase ( MEK ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK14 IL1B 12417253 1012954 Sphondin ( 50 microM ) did not affect the *induced* activations of p44/42 [MAPK] , p38 MAPK , and JNK . Positive_regulation MAPK14 IL1B 12500176 1026688 These data suggest that the presence of retinal holes and may *lead* to activation of HGF , [mitogen activated protein kinases (MAPK)] , c-jun and extracellular matrix remodeling , resulting in proliferative and migratory cells in the wounded retina . Positive_regulation MAPK14 IL1B 12507586 1038422 In this study we evaluated the role of epigallocatechin-3-gallate ( EGCG ) , a green tea polyphenol which mimics its anti-inflammatory effects , in modulating the induced *activation* of [MAPK] 's in human chondrocytes . Positive_regulation MAPK14 IL1B 12649265 1080068 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant MKK6 or p38beta2 MAPK inhibited *induced* p38 [MAPK] activation , COX-2 gene expression , and PGE2 release . Positive_regulation MAPK14 IL1B 12727980 1086558 P38 [MAPK] phosphorylation was *increased* by in nondecidualized ESC , whereas the IL-1 beta induced increase was suppressed in the decidualized cells . Positive_regulation MAPK14 IL1B 12727980 1086571 Treatment with 8-bromo-cAMP reduced *induced* phosphorylation of p38 [MAPK] in nondecidualized ESC . Positive_regulation MAPK14 IL1B 12727980 1086585 In contrast , treatment with H89 , a protein kinase A inhibitor , reversed a reduction in *induced* p38 [MAPK] phosphorylation in the decidualized cells . Positive_regulation MAPK14 IL1B 12727980 1086599 The altered property of decidualized cells is thought to be caused by attenuation of *induced* p38 [MAPK] phosphorylation in a way that involves the activation of the cAMP/protein kinase A pathway . Positive_regulation MAPK14 IL1B 12882449 1116290 NAC ( 1 mM ) also decreased the *induced* activation of p38 [MAPK] . Positive_regulation MAPK14 IL1B 12952251 1137418 Using Western-blot analysis , no effect of cAMP was found on the *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK14 IL1B 12952251 1137432 No decrease was observed in *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK14 IL1B 14563491 1154861 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Positive_regulation MAPK14 IL1B 15039421 1251237 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of , and RIP2 dependent *activation* of NF-kappaB and p38 [MAPK] mediated by the caspase recruitment domain . Positive_regulation MAPK14 IL1B 15111866 1241240 We further demonstrated that p38 [MAPK] is *activated* by and PDGF with different kinetics and that p38 MAPK is required for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation MAPK14 IL1B 15208668 1281344 *induced* the activation of extracellular signal regulated kinases-1/2 and P38 [mitogen activated protein kinase (MAPK)] , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation MAPK14 IL1B 15341531 1291762 In accordance with these findings , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) , which was attenuated by U0126 , SB202190 , or SP600125 , respectively . Positive_regulation MAPK14 IL1B 15389584 1354320 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] and JNK which was attenuated by pretreatment with U0126 or SP600125 , respectively . Positive_regulation MAPK14 IL1B 15489374 1359424 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and JNK was attenuated by pretreatment with U0126 , SB-202190 , or SP-600125 , respectively . Positive_regulation MAPK14 IL1B 15755725 1403422 The inhibitory effect of on alpha ENaC expression was *mediated* by the activation of p38 [MAPK] in both rat and human ATII cells and was independent of the activation of alpha v beta6 integrin and transforming growth factor-beta . Positive_regulation MAPK14 IL1B 16033422 1436166 Intrathecal *leads* to a time dependent up-regulation of phosphorylated p38 ( p-p38 ) [MAPK] protein expression in the spinal cord 30-240 min following IL-1beta injection ( i.t. ) . Positive_regulation MAPK14 IL1B 16033422 1436180 However , pretreatment with a p38 MAPK inhibitor significantly reduced the *induced* p-p38 [MAPK] expression by 38-49 % , and nearly completely blocked the subsequent iNOS expression ( reduction by 86.6 % ) , NO production , and thermal hyperalgesia . Positive_regulation MAPK14 IL1B 16043966 1459742 Western blot analysis demonstrated that *increased* the activation of phosphorylated MEK and p38 [MAPK] in GH3 cells . Positive_regulation MAPK14 IL1B 16140882 1450806 *induced* phosphorylation of [p38-MAPK] , but not that of c-Jun-N-terminal kinase or extracellular regulated kinase , was most susceptible to inhibition by low doses of PFE , and the addition of PFE blocked the activity of p38-MAPK in a kinase activity assay . Positive_regulation MAPK14 IL1B 16141635 1454870 DHA stimulated both rapid and prolonged activation of p44/42 , but not p38 , [mitogen activated protein kinase (MAPK)] *induced* by and PMA . Positive_regulation MAPK14 IL1B 16153910 1455439 The kidney was analyzed for expression of tumor necrosis factor alpha , , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 [mitogen activated protein kinase] , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation MAPK14 IL1B 16452991 1611739 Western blots showed that and TNF-alpha *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK14 IL1B 16528573 1549429 The aim of this study was to investigate if Gadd45b prevents *induced* beta cell [MAPK] signalling and apoptosis . Positive_regulation MAPK14 IL1B 16645161 1604678 significantly *increased* the phosphorylation of p38 [MAPK] and cPLA(2) . Positive_regulation MAPK14 IL1B 16698013 1575655 JST ( 0.01-1 mg/ml ) also attenuated the expression of cyclooxygenase (COX)-2 and activation of p38 [MAPK] *induced* by and A beta ( 1-42 ) . Positive_regulation MAPK14 IL1B 16718462 1584910 A synthetic peptide , C3d , reported to bind NCAM , did not activate MAPK or Akt as reported in neurons but inhibited *induced* [MAPK] activity , thereby mimicking the effect of SU5402 . Positive_regulation MAPK14 IL1B 16718462 1584935 We suggest that NCAM signalling through FGFR is required for efficient IL-1beta pro-apoptotic signalling by facilitating induced [MAPK] *activation* downstream of the NF-kappaB-MAPK branching point . Positive_regulation MAPK14 IL1B 16718462 1584972 Further , these data identify a novel function of C3d as an inhibitor of NCAM induced FGFR activity and of *induced* [MAPK] activation in beta cells . Positive_regulation MAPK14 IL1B 16959849 1639699 *caused* an increase in the phosphorylation of ERK , but not [p38MAPK] or c-Jun N-terminal kinase . Positive_regulation MAPK14 IL1B 16964394 1611555 Inhibitors of p38 [MAPK] and/or JNK significantly suppressed VEGF secretion both in the *presence* and absence of , while inhibitors of COX-2 , ERK1/2 , and PI3-K did not . Positive_regulation MAPK14 IL1B 17208222 1695814 Thalidomide also suppressed induced p38 [mitogen activated protein kinase (MAPK)] *activation* , while a p38 MAPK inhibitor destabilized COX-2 mRNA and the cytoplasmic shuttling of HuR induced by IL-1beta . Positive_regulation MAPK14 IL1B 17311279 1719291 *stimulated* phosphorylation of p42/p44 [MAPK] , p38 MAPK , and JNK was attenuated by pretreatment with U0126 , SB202190 , SP600125 , or transfection with these dominant negative mutants of MEK , ERK , p38 and JNK , respectively . Positive_regulation MAPK14 IL1B 17390080 1716136 We have previously demonstrated that *induced* HBD-2 mRNA expression in A549 cells through activation of nuclear factor-kappaB (NF-kappaB) transcriptional factor as well as p38 [mitogen activated protein kinase (MAPK)] , c-Jun N-terminal kinase (JNK) , or phosphatidylinositol-3-kinase (PI3K) . Positive_regulation MAPK14 IL1B 17390080 1716163 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Positive_regulation MAPK14 IL1B 17390080 1716193 Triptolide inhibited *induced* [MAPK] phosphatase-1 expression at the transcriptional level and resulted in sustained phosphorylation of JNK or p38 MAPK , explaining the little effect of triptolide on IL-1beta induced phosphorylation of these kinases . Positive_regulation MAPK14 IL1B 17438131 1742776 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by TNF-alpha and , but not by ansiomycin or sorbitol . Positive_regulation MAPK14 IL1B 17559635 1753263 also *activated* extracellular signal regulated kinase , p38 [MAPK] , and c-Jun N-terminal kinase . Positive_regulation MAPK14 IL1B 17645739 1793271 Interestingly , Dex attenuated *mediated* activation of p38 [MAPK] and JNK , but not of AKT . Positive_regulation MAPK14 IL1B 17694686 1782109 IL-1beta induced NO levels and thermal hyperalgesia in rats , likely via either inhibiting the mediated p38 [MAPK] *activation* and subsequent iNOS induction , or direct attenuation of the central iNOS activity , which therefore reduces the central sensitization of inflammatory pain . Positive_regulation MAPK14 IL1B 17920534 1804191 SA981 at a concentration of 100 microM partially inhibited *induced* phosphorylation of [p38MAPK] and Akt ( 12.0 % and 36.1 % inhibition of each total amount of phosphoprotein under IL-1beta coexistence condition , respectively ) . Positive_regulation MAPK14 IL1B 17925024 1835155 *stimulated* phosphorylation of c-jun amino-terminal kinase , p38 [MAPK] and extracellular signal regulated kinase-1/2 . Positive_regulation MAPK14 IL1B 18026701 1827822 Moreover , glucosamine suppressed the *induced* phosphorylation of p38 [MAPK] ( p < 0.05 at > 0.1 mM ) and the IL-1beta binding to its receptors ( p < 0.05 at 1 mM ) . Positive_regulation MAPK14 IL1B 18065201 1853664 *stimulated* activation of ERK1/2 and p38alpha [MAPK] mediates the transcriptional up-regulation of IL-6 , IL-8 and GRO-alpha in HeLa cells . Positive_regulation MAPK14 IL1B 18348730 1925316 The *activation* or inhibition of p38 [MAPK] by and/or SB203580 was analyzed by western blotting . Positive_regulation MAPK14 IL1B 18348730 1925329 *activated* the phosphorylation of p38 [MAPK] and this effect was abolished by SB203580 . Positive_regulation MAPK14 IL1B 18427719 1920724 Phosphorylated p38 ( Phos-p38 ) [mitogen activated protein kinase] was *stimulated* in SW-1353 cells by but not by HA alone . Positive_regulation MAPK14 IL1B 18556347 1965933 or leptin individually *induced* threonine/tyrosine phosphorylation of p38 [MAPK] , whereas only leptin induced tyrosine phosphorylation of JAK2 , suggesting that leptin may enhance hBD-2 production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with NF-kappaB , which is activated by IL-1beta . Positive_regulation MAPK14 IL1B 18667841 1948053 Furthermore , *induced* p38 [mitogen activated protein kinase (MAPK)] activation and upregulation of VEGF-C mRNA and protein in LLC cells was also suppressed by artemisinin or by the p38 MAPK inhibitor SB-203580 , suggesting that p38 MAPK could serve as a mediator of proinflammatory cytokine induced VEGF-C expression . Positive_regulation MAPK14 IL1B 19362079 2081460 *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 [mitogen activated protein (MAP) kinase] , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation MAPK14 IL1B 19522843 2136340 In chondrocytes , CS diminishes *induced* increases in p38 [mitogen activated protein kinase] ( p38MAPK ) and signal regulated kinase 1/2 ( Erk1/2 ) phosphorylation , and decreases nuclear factor-kappaB (NF-kappaB) nuclear translocation and as a consequence , reduces the formation of pro-inflammatory cytokines , IL-1beta and TNF-alpha , and pro-inflammatory enzymes , such as phospholipase A2 (PLA2) , cyclooxygenase 2 (COX-2) and nitric oxide synthase-2 (NOS-2) . Positive_regulation MAPK14 IL1B 19765281 2163524 Treatment with PIP-18 blocked *induced* p38 [MAPK] phosphorylation and resulted in attenuation of sPLA2-IIA and MMP mRNA transcription in RA SF cells . Positive_regulation MAPK14 IL1B 20060906 2218522 In the present study , we demonstrate that *caused* activation of p38 [mitogen activated protein kinase] and that the p38 inhibitor SB203580 significantly blocked the effect of IL-1beta on I ( NMDA-OUT ) in hippocampal CA1 neurons . Positive_regulation MAPK14 IL1B 20353947 2266471 In model 1 , a differentiation model , CLA *activation* of [MAPK] and induction of interleukin-8 (IL-8) , IL-6 , , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation MAPK14 IL1B 21659536 2455195 Distinct roles for Nod2 protein and autocrine in muramyl dipeptide *induced* [mitogen activated protein kinase] activation and cytokine secretion in human macrophages . Positive_regulation MAPK14 IL1B 24692548 2935246 At 1 h , this was responsible for the dexamethasone inhibition of induced [MAPK] *activation* and CXCL1 and CXCL2 mRNA expression , with a similar trend for CSF2 . Positive_regulation MAPK14 IL1B 9475519 486792 Of these , *activated* only [MAPK] . Positive_regulation MAPK14 IL1B 9475519 486805 In cultured rat astrocytes , *caused* activation of [MAPK] without inducing proliferation . Positive_regulation MAPK14 IL1B 9575890 502738 Our data also indicate that both insulin and IGF-I enhance *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation and SAPK activation . Positive_regulation MAPK14 IL1B 9582321 503937 Previously we reported that *induces* activation of JNK/SAPK and p38 [MAPK] with concomitant up-regulation of cyclooxygenase (Cox)-2 expression and prostaglandin E2 ( PGE2 ) synthesis . Positive_regulation MAPK14 IL1B 9614146 509330 By Western blotting with phosphospecific antibodies and by immunocomplex kinase assay , was shown to *activate* extracellular signal regulated kinase ( ERK ) 1/2 and p38 [mitogen activated protein kinase] ( p38 ) in islets and rat insulinoma cells . Positive_regulation MAPK14 IL1B 9786861 540915 We reported previously that rapidly *activates* the c-Jun NH2-terminal/stress activated protein kinases ( JNK/SAPK ) and p38 [mitogen activated protein kinase (MAPK)] and also induces Cox-2 expression and prostaglandin E2 ( PGE2 ) production . Positive_regulation MAPK14 IL1B 9786861 540961 Overexpression of the kinase-dead form of MKK3 or MKK6 demonstrated that either of these two mutant kinases inhibited *induced* p38 [MAPK] phosphorylation and Cox-2 expression but not JNK/SAPK phosphorylation and activation . Positive_regulation MAPK14 ITGB2 12600815 1099068 IL-3 , IL-5 , and GM-CSF could enhance p38 [MAPK] and NF-kappaB activity and *induce* ICAM-1 , CD11b , and expressions on eosinophils . Positive_regulation MAPK14 ITGB2 19843511 2203202 Furthermore , beta2 integrins modulated the capacity of isolated peritoneal macrophages to take up acetylated LDL and native LDL and to phagocytose apoptotic cells , possibly via *dependent* [mitogen activated protein kinase] signalling . Positive_regulation MAPK14 LBP 20615568 2309946 Despite activating NFkappaB , NOD1 ligand did not upregulate hepatocyte production of the acute phase proteins lipopolysaccharide binding protein , serum amyloid A , or soluble CD14 in cell culture supernatants , or upregulate mRNA expression of , serum amyloid A , C-reactive protein , or serum amyloid P . NOD2 ligand ( MDP ) did not *activate* hepatocytes when given alone , but did synergize with Toll-like receptor ligands , lipopolysaccharide (LPS) , and polyI : C to activate NFkappaB and [MAPK] . Positive_regulation MAPK14 MAP2K6 10050043 592947 In one set of experiments , we *inhibited* the activation of [MAPK] by pretreating cells with PD098059 , a specific inhibitor of ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAPK14 MAP2K6 10079106 595485 Although MKK3 , MKK4 , and all *activated* p38 [MAPk] in experimental models , only MKK3 was found to activate recombinant p38 MAPk in LPS treated neutrophils . Positive_regulation MAPK14 MAP2K6 10471331 641628 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Positive_regulation MAPK14 MAP2K6 10601295 574417 In addition , *activation* of p38 [MAPK] by constitutively active or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAPK14 MAP2K6 10713051 674396 Conversely , the inhibitors PD98059 and UO126 could *attenuate* EGF induced [mitogen activated protein kinase] activation , they do not affect the EGF induced mobility shift of caveolin-1 . Positive_regulation MAPK14 MAP2K6 10759527 683166 These results demonstrate that a plant can phosphorylate and *activate* [MAPK] , and that Tyr phosphorylation is critical for the catalytic activity of MAPK in plants . Positive_regulation MAPK14 MAP2K6 10816593 714748 The MAPK kinase selectively *stimulates* p38 [MAPK] and confers protection against stress induced apoptosis in cardiac myocytes . Positive_regulation MAPK14 MAP2K6 10891559 711210 MAP kinases (MAPK) in both G-1 and G-5 cells were indistinguishably phosphorylated , yet dependent [MAPK] *activation* was observed only in G-5 cells . Positive_regulation MAPK14 MAP2K6 11005808 752437 A inhibitor , PD98059 , *inhibited* heat shock ERK [MAPK] activation by > 75 % . Positive_regulation MAPK14 MAP2K6 11085935 750733 Similarly , *activation* of JNK by Ad-MKK7D and [p38-MAPK] by resulted in the increased expression of PGHS-2 . Positive_regulation MAPK14 MAP2K6 11237743 790322 The MAPK kinase ( ) inhibitor , PD98059 , *blocked* GSA stimulated [MAPK] activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Positive_regulation MAPK14 MAP2K6 11304531 826836 The *activation* of p38 [MAPK] by Galpha ( q ) and Gbetagamma was blocked by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Positive_regulation MAPK14 MAP2K6 11787422 891944 Indeed the MAPK kinase ( = ) inhibitor PD98059 *inhibits* the activation of parasite [MAPK] , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Positive_regulation MAPK14 MAP2K6 11822870 909072 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of [MAPK] pathway *inhibitors* ( inhibitors PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAPK14 MAP2K6 12009309 940830 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Positive_regulation MAPK14 MAP2K6 12203369 983236 Furthermore , PKC inhibitors or an inhibitor completely *suppressed* both TPA induced activation of [MAPK] and promotion of anchorage independent growth , but a cPKC-selective inhibitor partially suppressed TPA induced promotion of the growth . Positive_regulation MAPK14 MAP2K6 12356282 993864 IL-1beta induced p44/42 [mitogen activated protein kinase (MAPK)] activation was *inhibited* by the MAPK/extracellular signal regulated protein kinase ( ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK14 MAP2K6 12377770 1019990 These results suggest that MKK3 , rather than , *mediates* alphav integrin induced p38 [MAPK] activation . Positive_regulation MAPK14 MAP2K6 12450322 1018654 ANG II significantly increased aldosterone release , and this effect was inhibited by the LO inhibitor baicalein , as well as a specific p38 [MAPK] *inhibitor* , SB202190 , but not by PD098059 , a specific inhibitor of the ERK activator . Positive_regulation MAPK14 MAP2K6 12637559 1085496 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Positive_regulation MAPK14 MAP2K6 12659851 1073526 MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a ( MAP2K ) , which in turn *activates* a [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK14 MAP2K6 12845643 1108606 Finally , both ODQ and UO126 blocked the capacity of L-arginine to restore ERK ( 1/2 ) phosphorylation in L-NAME treated cells , demonstrating that GC and are both *required* for endogenous NO-mediated [MAPK] activation . Positive_regulation MAPK14 MAP2K6 15104236 1240323 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( ) inhibitor , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAPK14 MAP2K6 15172888 1288400 Importantly , the presence of inhibitors only at the time of the transport assay markedly *impaired* both insulin stimulated glucose uptake and [MAPK] signaling . Positive_regulation MAPK14 MAP2K6 15172888 1288497 Conversely , removal of inhibitors before the transport assay *restored* glucose uptake and [MAPK] signaling . Positive_regulation MAPK14 MAP2K6 15304546 1322524 Furthermore , *activation* of [ERK/MAPK] by the coexpression of constitutively active predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAPK14 MAP2K6 15365248 1294582 Treatment of keratinocytes with PD98059 , inhibitor , and SB20358 , p38 [MAPK] *inhibitor* , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAPK14 MAP2K6 15570612 1355578 Although the inhibitors *suppressed* [MAPK] phosphorylation in both OA- and AICAR treated oocytes , meiotic resumption was not causally linked to MAPK phosphorylation in either group . Positive_regulation MAPK14 MAP2K6 15867183 1404244 In cultured cardiac myocytes , specific *activation* of stress activated [mitogen activated protein kinase] , p38 , by upstream activator led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAPK14 MAP2K6 15879307 1411359 Conversely , constitutively active *induced* p38 [MAPK] activation that recapitulated the effects of polyphenols by inducing ERalpha phosphorylation and downstream activation of Akt , and eNOS . Positive_regulation MAPK14 MAP2K6 16157033 1455774 SB203580 , a [P38MAPK] *inhibitor* , and U0126 , a inhibitor , both completely blocked ADM mediated responses in MsC . Positive_regulation MAPK14 MAP2K6 17416211 1777893 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK14 MAP2K6 18401006 1925843 CyaA enhanced LPS induced phosphorylation of p38 [MAPK] and ERK in DC , and inhibitors of p38 MAPK , , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation MAPK14 MAP2K6 18754769 1968450 ( MKK) 3 and 6 are the main p38 [mitogen activated protein kinase] *activators* in mammals . Positive_regulation MAPK14 MAP2K6 18771907 1962695 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a inhibitor , and SB203580 , an *inhibitor* of p38 [mitogen activated protein (MAP) kinase] , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAPK14 MAP2K6 21892182 2491664 Further , we show that *activation* of p38 [MAPK] by expression of constitutively active ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAPK14 MAP2K6 22164285 2517912 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of and marked *activation* of p38 [MAPK] . Positive_regulation MAPK14 MAP2K6 22785235 2691908 TRH induced CRE promoter was inhibited by [mitogen activated protein kinase/ERK] kinase ( MEK ) inhibitor and was *increased* by overexpression of . Positive_regulation MAPK14 MAP2K6 7644477 318679 Inhibition of by PD 098059 *prevented* activation of [MAPK] and subsequent phosphorylation of MAPK substrates both in vitro and in intact cells . Positive_regulation MAPK14 MAP2K6 7822248 285612 ( MKK ) phosphorylates and *activates* [mitogen activated protein kinase (MAPK)] in response to stimulation of various eukaryotic signaling pathways . Positive_regulation MAPK14 MAP2K6 7889302 289456 2. Both nucleotides stimulate phosphorylation and *activation* of [mitogen activated protein kinase] and a biphasic phosphorylation of the up-stream . Positive_regulation MAPK14 MAP2K6 8180183 256256 This stimulation of the activator was temporally *followed* by increased activities of MEK and [MAPK] . Positive_regulation MAPK14 MAP2K6 8226933 235427 *Activation* of extracellular signal regulated kinase ( ERK ) or [mitogen activated protein kinase] by ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAPK14 MAP2K6 8394352 228257 We show that a similar activity phosphorylates and *activates* [MAPK] in both growth factor stimulated ( epidermal growth factor and thrombin ) and oncogene ( gip2 , v-src , and v-raf ) -transfected cells . Positive_regulation MAPK14 MAP2K6 8550616 346686 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Positive_regulation MAPK14 MAP2K6 8663100 368174 The [MAPK] and NHE activities induced by PMA were *inhibited* by staurosporine , a potent inhibitor for protein kinase C ( PKC ) , and by MAPK kinase ( ) inhibitor , PD98059 , but were not affected by the tyrosine kinase inhibitor genistein . Positive_regulation MAPK14 MAP2K6 8663100 368271 In contrast , both AVP induced [MAPK] and NHE activities were *inhibited* by genistein and inhibitor but were not affected by staurosporine . Positive_regulation MAPK14 MAP2K6 8816498 384311 *activates* [mitogen activated protein kinase (MAPK)] , which phosphorylates other kinases as well as transcription factors . Positive_regulation MAPK14 MAP2K6 9135064 427628 In addition to dependent [MAPK] *activation* , we provide evidence for MEK independent regulation of the MAPKs . Positive_regulation MAPK14 MAP2K6 9166761 432476 The first step in [MAPK] *activation* by must be the formation of a MEK x MAPK enzyme-substrate complex , followed by phosphorylation producing monophosphorylated MAPK ( pMAPK ) . Positive_regulation MAPK14 MAP2K6 9626658 511910 These results indicate that *mediates* the IGF-I/insulin induced p42/ p44 [MAPK] activation . Positive_regulation MAPK14 MAP2K6 9864179 582745 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of ERK , but not p38 [MAPK] , induced by G-CSF , GM-CSF , or TNF . Positive_regulation MAPK14 MMP7 16848631 1588323 and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 [mitogen activated protein kinase] activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MAPK14 MMP7 21999204 2547386 Mesothelin enhances invasion of ovarian cancer by *inducing* through [MAPK/ERK] and JNK pathways . Positive_regulation MAPK14 MUC16 11481474 843879 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a [mitogen activated protein kinase] ( Erk 1/2 ) , and *activation* of transcription . Positive_regulation MAPK14 PECAM1 18029285 1866923 In contrast , expression of Delta15 in PECAM-1-/- bEND cells *had* minimal effects on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Positive_regulation MAPK14 PGC 22105890 2599543 Our studies also revealed that overexpression of in cardiomyocytes *inhibited* basal and T3-induced p38 [MAPK] phosphorylation . Positive_regulation MAPK14 PIGR 20450283 2257149 Induction of expression in HT-29 cells *required* NF-kappaB signaling but not [MAPK] signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation MAPK14 PLAT 19436314 2107040 cerebrospinal fluid and brain parenchymal ERK [MAPK] was elevated by H/I and this upregulation was *potentiated* by , but blunted by RBC-tPA . Positive_regulation MAPK14 PLAT 21037505 2499496 Red blood blocked c-Jun-N-terminal kinase but *potentiated* p38 [mitogen activated protein kinase] upregulation after photothrombotic injury . Positive_regulation MAPK14 PLAU 10766865 684606 surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha [mitogen activated protein kinase] activity . Positive_regulation MAPK14 PLAU 15031204 1257170 In HeLa cells the dominant negative form of JNK interferes with the p42/p44 [MAPK] *activation* of the . Positive_regulation MAPK14 PLAU 15874933 1405699 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 [MAPK] , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Positive_regulation MAPK14 PLAU 15874933 1405732 Although *induced* phosphorylation of both ERK1/2 and p38 [MAPK] was blocked by Galphai inhibition , inhibition of PI3K and Ras decreased the uPA induced phosphorylation of ERK1/2 but not p38 MAPK . Positive_regulation MAPK14 PLAU 18656457 1960565 Exogenous administered at 4 h post H/I further *stimulated* ERK [MAPK] phosphorylation , which was blocked by RAP . Positive_regulation MAPK14 PLAU 9660790 517500 The receptor *mediates* tyrosine phosphorylation of focal adhesion proteins and activation of [mitogen activated protein kinase] in cultured endothelial cells . Positive_regulation MAPK14 PLAU 9660790 517513 The *induced* activation of [MAPK] was completely inhibited by genistein , but not by 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo [ 3 , 4-d ] pyrimidine , a specific inhibitor of Src family kinases . Positive_regulation MAPK14 PODXL 17616675 1769274 expression also *led* to an increase in [mitogen activated protein kinase (MAPK)] and phosphatidylinositol 3-kinase (PI3K) activity . Positive_regulation MAPK14 PODXL 17616675 1769321 These findings suggest that leads to increased in vitro migration and invasion , increased MMP expression , and *increased* activation of [MAPK] and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MAPK14 PTGER2 19233324 2072060 Further , PGE ( 2 ) , EP2A and EP4A did not increase BMP2/4 mRNA levels in RC cells , and *induced* phosphorylation of p38 [MAPK] was not eliminated by Noggin . Positive_regulation MAPK14 SLC38A3 15331357 1288022 In contrast , *stimulated* [MAPK] activation was blocked by > 80 % by dominant negative Ras but not by dominant negative Rho and Cdc42 . Positive_regulation MAPK14 SNCAIP 12639553 1068704 In addition , [MAPK] was *activated* by through Edg-1 , Sph-1-P receptor . Positive_regulation MAPK14 SPHK1 18602364 1941506 As a result , inhibition of by SKI *blocked* phosphorylation of p38 [MAPK] , showing that SPHK activation by IL-18 is an upstream signal of p38 MAPK activation . Positive_regulation MAPK14 STK39 17237610 1690286 The phosphorylation of cytoplasmic p38 [MAPK] in Akata cells was *reduced* by the inhibitor , 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperazine ( H7 ) . Positive_regulation MAPK14 TLR7 16424221 1515575 MKP-1-deficient macrophages also show enhanced constitutive and *induced* activation of p38 [MAPK] . Positive_regulation MAPK14 TLR7 23979601 2850655 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Positive_regulation MAPK14 TLR7 24879442 2941006 GIT2 terminates *induced* NF-?B and [MAPK] signaling by recruiting the deubiquitinating enzyme Cylindromatosis to inhibit the ubiquitination of TRAF6 . Positive_regulation MAPK14 TNF 10504489 648983 Pretreatment with SB203580 ( 10 microM ) had no effect on basal or TNF-alpha stimulated phosphorylation of p38 MAPK but completely abolished *stimulated* p38 [MAPK] activity . Positive_regulation MAPK14 TNF 10521481 653113 The study presented here shows that autoregulation of gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 [mitogen activated protein (MAP) kinase] activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation MAPK14 TNF 10570180 568161 Furthermore , LPS , UV irradiation , and *caused* activation of p38 [MAPK] whereas IFN-gamma did not . Positive_regulation MAPK14 TNF 10601128 574206 alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation MAPK14 TNF 10640438 577505 IL-1 beta and also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK14 TNF 10669634 665808 In this study , we show that *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation MAPK14 TNF 10753884 682343 Moreover , *stimulated* both the NF-kappaB and [mitogen activated protein (MAP) kinase] ( extracellular signal regulated kinase , c-Jun NH ( 2 ) -terminal kinase , and p38 MAP kinase ) signaling pathways in astrocytes . Positive_regulation MAPK14 TNF 10783388 707850 dependent p38 [MAPK] *activation* was detected in both Mo7e and Hut-78 cells and was blocked by the p38 MAPK inhibitor , SB203580 . Positive_regulation MAPK14 TNF 10783388 707903 SB203580 did not affect TNF-alpha signaled nuclear translocation and DNA binding activity of NF-kappaB , and inhibition of NF-kappaB function did not affect *induced* p38 [MAPK] activation , indicating that these events are not dependent on each other . Positive_regulation MAPK14 TNF 10864897 705727 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK14 TNF 10864897 705779 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by and IL-1beta . Positive_regulation MAPK14 TNF 11095634 755300 rapidly *activated* [MAPK] and increased the extent of attachment , spreading and migration on fibronectin and collagen type I ( P < 0.01 ) but not on collagen type IV . Positive_regulation MAPK14 TNF 11108246 756729 *activates* extracellular regulated kinase-1/2 ( ERK1/2 ) and [p38MAPK] . Positive_regulation MAPK14 TNF 11108836 757040 In RAW264 cells which differentiate into osteoclast-like multinucleated cells by TNF treatment alone , activation of p38 [mitogen activated protein (MAP) kinase] *induced* by murine was comparable to and independent of the receptor activator of necrosis factor-kappaB ligand . Positive_regulation MAPK14 TNF 11156586 780616 1. We have previously shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce interleukin-8 (IL-8) by human pulmonary vascular endothelial cells . Positive_regulation MAPK14 TNF 11167962 783067 It has previously been shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce cytokine , including RANTES , that N-acetylcysteine (NAC) attenuates cytokine production by human bronchial epithelial cells ( BECs ) , and that sensitivity to TNFalpha is inversely correlated with cellular redox state . Positive_regulation MAPK14 TNF 11266661 797170 However , *caused* no activation of p42/p44 [MAPK] or cytosolic phospholipase A(2) activity . Positive_regulation MAPK14 TNF 11277995 798112 *activates* extracellular regulated kinases ( ERKs ) and p38 [mitogen activated protein kinase] ( p38MAPK ) , and inhibits the expression of uncoupling protein-1 (UCP-1) and adipocyte-specific genes in rat fetal brown adipocytes . Positive_regulation MAPK14 TNF 11319753 806840 SB 203580 , a selective inhibitor of p38 MAPK , inhibited IL-1 and *induced* p38 [MAPK] activity and IL-6 production ( IC ( 50 ) s 0.3 -- 0.5 microM ) in osteoblasts and chondrocytes . Positive_regulation MAPK14 TNF 11319753 806865 In addition , IL-1 and also *activated* p38 [MAPK] in fetal rat long bones and p38 MAPK inhibitors inhibited IL-1- and TNF stimulated bone resorption in vitro in a dose dependent manner ( IC ( 50 ) s 0.3 -- 1 microM ) . Positive_regulation MAPK14 TNF 11435466 832530 However , the cytotoxic responses to daunorubicin and exogenous ceramide remain unaltered , as do the induced p42/p44 [MAPK] *activation* and CD54 expression . Positive_regulation MAPK14 TNF 11438547 843395 *activated* p38 [MAPK] and p44/p42 MAPK in wild-type but not in p60 ( -/- ) , p80 ( -/- ) , or p60 ( -/- ) p80 ( -/- ) macrophages . Positive_regulation MAPK14 TNF 11494147 846174 In this study we demonstrate that *triggers* only modest proliferation , as well as p44/p42 [mitogen activated protein kinase (MAPK)] and NF-kappaB activation , in MM.1S multiple myeloma ( MM ) cells . Positive_regulation MAPK14 TNF 11495721 846394 Furthermore , overexpression of dominant negative mutants , H-Ras-15A and Raf-N4 , significantly suppressed p42/p44 [mitogen activated protein kinase (MAPK)] activation *induced* by and PDGF-BB and attenuated the effect of TNF-alpha on BK-induced IP response , indicating that Ras and Raf may be required for activation of these kinases . Positive_regulation MAPK14 TNF 11509550 848363 Although IL-1 beta and each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK14 TNF 11592111 869663 Lipopolysaccharide (LPS) treatment of a microglial cell line ( N9 ) *induced* a time dependent activation of both p38 mitogen activated protein kinase ( p38 [MAPK] ) and nuclear factor-kappaB (NFkappaB) , with consequent increases in interleukin-1alpha (IL-1alpha) , , and nitric oxide ( NO ) production . Positive_regulation MAPK14 TNF 11694522 896415 *activated* the three mammalian [MAPK] , p44/42 , JNK , and p38 , in a distinct time- and concentration dependent manner . Positive_regulation MAPK14 TNF 11694522 896441 In conclusion , although *activates* all three known [MAPK] in human preadipocytes , only p44/42 and JNK appear to be involved in the regulation of lipolysis . Positive_regulation MAPK14 TNF 11750919 898173 Biochemical and immunocytochemical analysis showed that *activated* p38 mitogen activated protein kinase ( p38MAPK ) and c-Jun N-terminal kinase (JNK) but not p42/p44 [MAPK] . Positive_regulation MAPK14 TNF 11820362 908740 *activated* p38 [MAPK] and stimulated IL-6 secretion by MG-63 cells , and pre-incubation of cells with the p38 MAPK inhibitor abrogated TNF-alpha dependent IL-6 secretion . Positive_regulation MAPK14 TNF 11820362 908769 Transfection of IL-6 full-length and 5-deletion gene promoter reporter constructs indicated that p38 [MAPK] *activation* by enhanced IL-6 gene expression , and that the p38 MAPK-responsive region resided in the proximal 260-bp segment . Positive_regulation MAPK14 TNF 11820362 908805 In conclusion , although p38 [MAPK] *activation* by stimulates IL-6 secretion by MG-63 cells , it has opposing effects on c/EBPbeta and NFkappaB activity . Positive_regulation MAPK14 TNF 11930247 927420 The p44/42 [MAPK] activity was significantly *enhanced* by and the TNF-alpha effect was opposed by rhIL-10 . Positive_regulation MAPK14 TNF 11930247 927433 It is suggested that rhIL-10 can inhibit *induced* VSMC proliferation and phosphorylation of p44/42 [MAPK] . Positive_regulation MAPK14 TNF 12095140 960566 significantly increased permeability and *induced* p38 and ERK [MAPK] activation compared with controls ( P < 0.05 ) . Positive_regulation MAPK14 TNF 12114204 963996 *increased* the phosphorylation of p38 [MAPK] within 15 min. Anisomycin , an activator of p38 MAPK , increased p38 MAPK phosphorylation and decreased SP-A mRNA levels in a dose dependent manner . Positive_regulation MAPK14 TNF 12130576 966582 Phosphorylation of p38 [MAPK] was *induced* by RANKL , IL-1 , , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation MAPK14 TNF 12131776 966860 IL-1 beta and *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK14 TNF 12297009 991039 In this study , we examined the anti-apoptotic role of p38 [MAPK] that is *activated* by in neuronal PC12 cells . Positive_regulation MAPK14 TNF 12297009 991052 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Positive_regulation MAPK14 TNF 12393915 1025437 This model probiotic also inhibits *activation* of the pro-apoptotic [p38/mitogen activated protein kinase] by , interleukin-1alpha , or gamma-interferon . Positive_regulation MAPK14 TNF 12511413 1079040 The treatment of RAW264 cells with TSA and NaB inhibited *induced* nuclear translocation of NF-kappa B and sRANKL induced activation of p38 [mitogen activated protein kinase (MAPK)] signals . Positive_regulation MAPK14 TNF 12631113 1067617 Additional experiments examining the role of cAMP on MC fractalkine expression showed that the incubation of MCs with TNF-alpha and either db-cAMP or forskolin attenuated TNF-alpha stimulated fractalkine mRNA and protein expression , preceded by attenuation of *activated* phosphorylation of p42/44 [MAPK] , and c-Jun , but not phosphorylation of PKCzeta/iota or nuclear translocation of NF-kappaB . Positive_regulation MAPK14 TNF 12637577 1099311 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and *requires* p38 [MAPK] activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation MAPK14 TNF 12665666 1030372 This study was undertaken to examine the relationship between induced cardiomyocyte apoptosis and *activation* of p38 [mitogen activated protein kinase (MAPK)] through oxidative stress . Positive_regulation MAPK14 TNF 12665666 1030385 Corresponding to the apoptotic effect , at 10 ng/mL *caused* rapid phosphorylation of p38 [MAPK] in wild-type cardiomyocytes . Positive_regulation MAPK14 TNF 12694807 1080911 *induced* the phosphorylation of p44/p42 [mitogen activated protein (MAP) kinase] and p38 MAP kinase . Positive_regulation MAPK14 TNF 12731668 1086847 On the other hand , GM-CSF- or *induced* phosphorylation of ERK and p38 [MAPK] was unaffected by these inhibitors at the concentrations effective for the inhibition of O2- release and adherence . Positive_regulation MAPK14 TNF 12829618 1113806 However , *induced* [p38-MAPK] phosphorylation was markedly diminished in mkk3-/- vs mkk3+/+ hearts ( percent basal , 127+/-23 versus 540+/-267 , respectively , P=0.04 ) , suggesting an MKK independent activation mechanism by ischemia . Positive_regulation MAPK14 TNF 12844496 1149730 Rho inhibition decreases *induced* endothelial [MAPK] activation and monolayer permeability . Positive_regulation MAPK14 TNF 12844496 1149743 Because GTP binding proteins have been implicated in MAPK activation , we now hypothesize that the GTP binding protein Rho is a mediator of *induced* [MAPK] activation and increased endothelial permeability . Positive_regulation MAPK14 TNF 12844496 1149757 C3 transferase attenuated *induced* [MAPK] activation and blocked TNF induced endothelial permeability . Positive_regulation MAPK14 TNF 12867430 1141998 Subsequently , mediated p38 [MAPK] *activation* induced sialidase activity and CD44-HA binding . Positive_regulation MAPK14 TNF 12867430 1142107 Taken together , our results suggest that induced p38 [MAPK] *activation* may regulate the induction of functionally active HA-binding form of CD44 by activating sialidase in LPS stimulated human monocytic cells . Positive_regulation MAPK14 TNF 12881424 1116132 Importantly , does not induce ROS accumulation or prolonged MAPK activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently *induces* prolonged [MAPK] activation and necrotic cell death Positive_regulation MAPK14 TNF 12893778 1121030 We show that MKK3 and MKK6are essential for *stimulated* p38 [MAPK] activation . Positive_regulation MAPK14 TNF 12960255 1158288 To investigate a potential interplay between induced *activation* of p38 [MAPK] and NF-kappaB , the p38 MAPK inhibitor SB203580 and a dominant negative p38 MAPK mutant were used . Positive_regulation MAPK14 TNF 14516792 1147204 [MAPK] pathway *activation* via was confirmed by marked AP-1 activation detected in EMSA . Positive_regulation MAPK14 TNF 14561851 1165106 In cultured human umbilical vein endothelial cells ( HUVECs ) , and lipopolysaccharide *increased* phosphorylation of p38 [MAPK] ( P-p38 MAPK ) and increased ICAM-1 expression . Positive_regulation MAPK14 TNF 14592823 1209465 Analyzing the individual contribution of PF-4 and its costimuli in the control of these functions at the signaling level , we demonstrate that *induced* activation of p38 [mitogen activated protein (MAP) kinase] ( but not extracellular regulated kinase [ Erk ] kinases ) acts as general and essential costimulatory signal in PF-4 dependent neutrophil exocytosis . Positive_regulation MAPK14 TNF 14632659 1170651 *activated* p38 [MAPK] in DCs only at an early time-point ( 15 min ) . Positive_regulation MAPK14 TNF 14654378 1176829 These findings suggest that the pre-ischemic *activation* of [p38-MAPK] by does not contribute to cardioprotection afforded by this agent . Positive_regulation MAPK14 TNF 15002040 1265082 Consistent with the abrogation of osteoclastogenic effect of DcR3 by TNFR-Fc , DcR3 treatment can *induce* osteoclastogenic cytokine release through ERK and p38 [MAPK] signaling pathways . Positive_regulation MAPK14 TNF 15139014 1246958 The increase in release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not [mitogen activated protein kinase (MAPK)] , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation MAPK14 TNF 15191888 1295240 Treatment of endothelial cells with SphK1 siRNA suppressed *induced* increase in MCP-1 mRNA levels , MCP-1 protein secretion , and activation of p38 [MAPK] . Positive_regulation MAPK14 TNF 15212763 1262318 Interestingly , Ad5NIK , but not , *induces* RelA S536 and p38 [mitogen activated protein kinase (MAPK)] phosphorylation in IKKgamma ( -/- ) cells . Positive_regulation MAPK14 TNF 15233873 1269391 A. semen also inhibited the expression of and the *activation* of [mitogen activated protein kinase] , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation MAPK14 TNF 15240695 1270283 TNF activates Syk protein tyrosine kinase leading to induced [MAPK] *activation* , NF-kappaB activation , and apoptosis . Positive_regulation MAPK14 TNF 15240695 1270303 TNF induced Syk activation was abolished by piceatannol ( Syk-selective inhibitor ) , which led to the suppression of *induced* activation of c- JNK , p38 [MAPK] , and p44/p42 MAPK . Positive_regulation MAPK14 TNF 15240695 1270319 Jurkat cells that did not express Syk ( JCaM1 , JCaM1/lck ) showed lack of *induced* Syk , JNK , p38 MAPK , and p44/p42 [MAPK] activation , as well as TNF induced IkappaBalpha phosphorylation , IkappaBalpha degradation , and NF-kappaB activation . Positive_regulation MAPK14 TNF 15240695 1270350 Overall , our results demonstrate that Syk activation plays an essential role in *induced* activation of JNK , p38 [MAPK] , p44/p42 MAPK , NF-kappaB , and apoptosis . Positive_regulation MAPK14 TNF 15240725 1270458 p38 [MAPK] was *activated* by and oxidants in nonadherent conditions i.e. , with 10 mM EDTA . Positive_regulation MAPK14 TNF 15240725 1270472 Finally , p38 [MAPK] *activation* by was blocked by diphenylene iodonium , an inhibitor of flavoprotein oxidoreductase , and by the free radical scavenger N-acetylcystein . Positive_regulation MAPK14 TNF 15265936 1275734 Besides NF-kappa B , celecoxib also suppressed *induced* JNK , p38 [MAPK] , and ERK activation . Positive_regulation MAPK14 TNF 15290420 1278551 Halothane or isoflurane augmented the LPS- and *induced* activation of p38 [MAPK] . Positive_regulation MAPK14 TNF 15304089 1284480 DNCB , NiSO ( 4 ) and *activated* p38 [mitogen activated protein kinases (MAPK)] and c-jun N-terminal kinase ( JNK ) . Positive_regulation MAPK14 TNF 15322069 1333422 We have also investigated the phosphorylation of p42/44 [MAPK] and *upregulation* of RhoA protein by . Positive_regulation MAPK14 TNF 15452110 1341993 In contrast , induced p42/p44 [MAPK] *activation* and CD54 expression remained unaltered . Positive_regulation MAPK14 TNF 15589482 1356213 In addition , luteolin inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , IkappaB degradation , and NF-kappaB activation . Positive_regulation MAPK14 TNF 15659876 1350308 The anabolic effect of was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an extracellular regulated kinases (ERK) . Positive_regulation MAPK14 TNF 15696169 1372162 Using TCPTP-deficient fibroblasts , we show here that TCPTP regulates *induced* [MAPK] but not NF-kappaB signaling . Positive_regulation MAPK14 TNF 15696169 1372202 These results link TCPTP and Src tyrosine kinases to the selective regulation of *induced* [MAPK] signaling and identify a previously unknown mechanism for modulating inflammatory responses mediated by TNF . Positive_regulation MAPK14 TNF 15703956 1497469 *Activation* of p38 [mitogen activated protein (MAP) kinase] and phosphatidylinositol 3-kinase (PI3K) by was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation MAPK14 TNF 15792609 1386795 By stimulation of in AM-1 cells , the phosphorylation of Akt ( Ser473 ) and p44/42 [mitogen activated protein kinase (MAPK)] ( Thr202/Tyr204 ) was markedly *increased* in TNFalpha concentration and time dependent manner . Positive_regulation MAPK14 TNF 15792609 1386808 Pretreatment with U0126 , mitogen activated extracellular regulated kinase ( MEK) 1/2 inhibitor , prior to TNFalpha stimulation , specifically inhibited *induced* phosphorylation of p44/42 [MAPK] ( Thr202/Tyr204 ) in AM-1 cells . Positive_regulation MAPK14 TNF 15792609 1386824 Meanwhile , pretreatment with LY294002 , phosphatidylinositol-3-OH kinase (PI3K) inhibitor , could inhibit both *induced* phosphorylation of Akt ( Ser473 ) and p44/42 [MAPK] ( Thr202/Tyr204 ) . Positive_regulation MAPK14 TNF 15823554 1393913 Furthermore , potently *activated* p38 [MAPK] , JNK , and NF-kappaB . Positive_regulation MAPK14 TNF 15837794 1432550 Expression of this protein inhibited *induced* activation of NFkappaB , JNK , and p38 [MAPK] and sensitized the cells to TNF induced apoptosis . Positive_regulation MAPK14 TNF 15845648 1425548 *induces* a more than tenfold increase in p38 [mitogen activated protein kinase (MAPK)] but not extracellular signal regulated kinase phosphorylation . Positive_regulation MAPK14 TNF 15870903 1405548 In addition , GA inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , I kappa B alpha degradation , and NF-kappa B activation . Positive_regulation MAPK14 TNF 16009485 1441405 Moreover , p44/42 [mitogen activated protein kinase] appears to partly *mediate* the negative effect of insulin but not on ATGL . Positive_regulation MAPK14 TNF 16023081 1441589 Ellagic acid inhibited IL-1beta- and induced *activation* of activator protein-1 and mitogen activated protein kinases ( extracellular signal regulated kinase , c-Jun N-terminal kinase and p38 [mitogen activated protein kinase] ) , but not of nuclear factor-kappaB . Positive_regulation MAPK14 TNF 16025396 1435612 *activated* the phosphorylation of p44/42 [MAPK] , p38 MAPK , SAPK/JNK and Akt in mesangial cells . Positive_regulation MAPK14 TNF 16025396 1435628 PGE1 inhibited the *induced* phosphorylation of SAPK/JNK and Akt , but not p44/42 [MAPK] and p38 MAPK . Positive_regulation MAPK14 TNF 16080915 1442768 Comparative gene array analysis of *induced* [MAPK] and NF-kappaB signaling pathways between retinal ganglion cells and glial cells . Positive_regulation MAPK14 TNF 16140562 1499254 These results suggested that TNFalpha induced both cell survival and apoptosis pathways in ameloblastoma and potential of TNFalpha in inducing apoptosis can be improved by inhibiting *induced* Akt and p44/42 [mitogen activated protein kinase (MAPK)] cell survival pathways . Positive_regulation MAPK14 TNF 16275991 1480302 Angiotensin II , , or epidermal growth factor *induced* [MAPK] phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation MAPK14 TNF 16291729 1526071 *Activation* of [MAPK] and Akt by anti-HER2/neu inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation MAPK14 TNF 16314440 1487000 treatment *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation in NPCs , and SB202190 , an inhibitor of p38 MAPK , blocked TNF-alpha induced chemokine production . Positive_regulation MAPK14 TNF 16325162 1511665 Furthermore , APE1/ref-1 overexpression inhibited the *induced* increase in intracellular superoxide and p38 [MAPK] phosphorylation . Positive_regulation MAPK14 TNF 16452991 1611738 Western blots showed that IL-1beta and *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK14 TNF 16517732 1530938 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of , but not IL-6 , *requires* the activity of p38 [MAPK] . Positive_regulation MAPK14 TNF 16573652 1556137 HA-mediated production *required* p38 [MAPK] , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation MAPK14 TNF 16682409 1584058 Further , the deletion of NQO1 abolished *induced* c-Jun N-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] activation . Positive_regulation MAPK14 TNF 16781693 1585616 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and and the *activation* of [MAPK] 's are potentially positive signals for IL-10 production . Positive_regulation MAPK14 TNF 16798728 1638535 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Positive_regulation MAPK14 TNF 16875982 1593563 *activates* [p38-MAPK] , a stress-responsive kinase implicated in contractile depression and cardiac injury . Positive_regulation MAPK14 TNF 16875982 1593577 Under conditions of constant coronary flow , the [p38-MAPK] activation and contractile depression *induced* by , though attenuated , remained sensitive to the absence of MKK3 or the presence of SB203580 . Positive_regulation MAPK14 TNF 16875982 1593591 *activates* [p38-MAPK] in the intact heart and in isolated cardiac myocytes through MKK3 . Positive_regulation MAPK14 TNF 16982923 1617363 Compared with wild-type cells , MIF-deficient cells were hyporesponsive to IL-1- and *induced* [MAPK] activity , AP-1 activity , and cellular proliferation , while NF-kappaB function was preserved . Positive_regulation MAPK14 TNF 17070777 1649834 Inhibition of Syk down-regulated *induced* p38 and p44/42 [MAPK] phosphorylation and nuclear translocation of p65 NF-kappaB . Positive_regulation MAPK14 TNF 17099067 1676201 Importantly , Dex is able to increase the expression of MKP-1 , which causes an inactivation of *induced* p38 [MAPK] and mediates inhibition of E-selectin expression . Positive_regulation MAPK14 TNF 17126899 1677674 Stimulation of ECs with *induced* rapid increases in the phosphorylation of their mitogen activated protein kinases ( MAPKs ) [ extracellular signal regulated kinase ( ERK ) , c-Jun-NH2-terminal kinase (JNK) , and p38 [MAPK] ] ; Positive_regulation MAPK14 TNF 17126905 1686549 Differential regulation of and GM-CSF *induced* activation of P38 [MAPK] in neutrophils and eosinophils . Positive_regulation MAPK14 TNF 17138860 1653547 The role of delta-PKC in mediated *activation* of [MAPK] is not known . Positive_regulation MAPK14 TNF 17138860 1653573 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 MAPK are involved in TNF antiapoptotic signaling and whether delta-PKC is a key regulator of [MAPK] *activation* by . Positive_regulation MAPK14 TNF 17138860 1653599 In human neutrophils , *activated* both p38 [MAPK] and ERK1/2 principally via TNFR-1 . Positive_regulation MAPK14 TNF 17158449 1694257 A green fluorescent protein fusion protein containing the last 100 residues of TAK1 ( TAK1-C100 ) abolished the interaction of endogenous TAB2/TAB3 with TAK1 , the phosphorylation of TAK1 , and prevented the activation of IKK and [MAPK] *induced* by IL-1 , , and RANKL . Positive_regulation MAPK14 TNF 17161959 1694539 Upon examination of the signaling components , we found that was a potent *activator* of p38 , p44/42 , p54/46 [MAPK] , and IkappaBalpha ( IkappaBalpha ) . Positive_regulation MAPK14 TNF 17172975 1679387 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the [MAPK] , and production of . Positive_regulation MAPK14 TNF 17172975 1679413 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the [MAPK] , and production of . Positive_regulation MAPK14 TNF 17189827 1680167 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Positive_regulation MAPK14 TNF 17202326 1680815 Augmented lipopolysaccharide induced production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK14 TNF 17202326 1680841 In this study , we show that augmented LPS induced production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK14 TNF 17218473 1732517 The RhoA inhibitor C3 exoenzyme and the ROCK inhibitor Y-27632 both attenuated induced [MAPK] *activation* and blocked AR expression in HIMEC . Positive_regulation MAPK14 TNF 17220297 1703054 TRAF2 and ASK1 play essential roles in *induced* [mitogen activated protein kinase] signaling . Positive_regulation MAPK14 TNF 17258890 1725454 The effects of and FasL on GrB expression were specifically *mediated* by [p38MAPK] ( Mitogen-activated-protein-kinase ) activation . Positive_regulation MAPK14 TNF 17425653 1748784 The percentage increases in IL-18 induced phosphorylation of extracellular signal regulated kinase ( ERK ) in Th cells of NDN and DN were significantly higher than controls ( P < 0.05 ) , while the percentage increase in *induced* phosphorylation of p38 [MAPK] in monocytes and IL-18 induced phosphorylation of p38 MAPK in Th cells and monocytes were significantly higher in NDN patients than controls . Positive_regulation MAPK14 TNF 17438131 1742775 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation MAPK14 TNF 17438336 1749076 FAK promoted *stimulated* [MAPK] activation needed for maximal IL-6 production . Positive_regulation MAPK14 TNF 17438336 1749097 Analysis of FAK ( -/- ) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity , Tyr-397 phosphorylation , and the Pro-712/713 proline-rich region of FAK were required for *stimulated* [MAPK] activation and IL-6 production . Positive_regulation MAPK14 TNF 17446186 1749511 *increased* p38 [MAPK] phosphorylation , potently stimulated IRS-1 serine phosphorylation , and blunted insulin stimulated IRS-1 tyrosine and Akt phosphorylation and eNOS activity . Positive_regulation MAPK14 TNF 17531219 1762171 On the other hand , aloe emodin did not affect induced *activation* of p38 [mitogen activated protein kinase] or generation of reactive oxygen species . Positive_regulation MAPK14 TNF 17607712 1798190 Although *induced* the activation of p38 [MAPK] , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation MAPK14 TNF 17725582 1801635 MAC inhibited *induced* p38 [mitogen activated protein kinase] activation and cell death in cultured Schwann cells . Positive_regulation MAPK14 TNF 17895408 1823966 IA did not interfere with *induced* activation of c-Jun N-terminal kinase (JNK) and p38 [mitogen activated protein kinase] . Positive_regulation MAPK14 TNF 17942934 1814215 Deletion of NQO2 also abolished *induced* c-Jun NH2-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] activation . Positive_regulation MAPK14 TNF 17994109 1851163 triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 [MAPK] , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation MAPK14 TNF 18039275 1828529 Further downstream in this axis of signalling , blockade *reduces* only acute bronchoconstriction , while [MAPK] inhibition abrogates completely endotoxin induced inflammation . Positive_regulation MAPK14 TNF 18060043 1853603 In cultures of Schwann cells , astrocytes , and microglia , sLRP-alpha inhibited *induced* activation of p38 MAPK and [ERK/MAPK] . Positive_regulation MAPK14 TNF 18061162 1861517 We demonstrate that *induced* proliferation of C4HD murine mammary tumor cells and of T47D cells through the activation of p42/p44 [MAPK] , JNK , PI3-K/Akt pathways and nuclear factor-kappa B (NF-kappa B) transcriptional activation . Positive_regulation MAPK14 TNF 18091748 1847368 *induced* phosphorylation of extracellular signal regulated kinase ( ERK ) and Akt , but not p38 [mitogen activated protein kinase (MAPK)] , was attenuated by nicardipine , cilnidipine , benidipine , efonidipine , and azelnidipine . Positive_regulation MAPK14 TNF 18227157 1884366 It was shown that these three proteins could ( i ) induce expression of and tissue factor and ( ii ) *induce* phosphorylation of p44/42 [mitogen activated protein kinases (MAPK)] and activation of early growth response factor 1 (Egr-1) . Positive_regulation MAPK14 TNF 18258304 1884797 However , over-expression of a dominant negative form of Rac strongly inhibited induced p42/44 [MAPK] kinase *activation* , but had little effect upon JNK and no effect upon p38 MAPK activity . Positive_regulation MAPK14 TNF 18287053 1872490 Here , we show that the murine CMV M45 protein binds to RIP1 and inhibits *induced* activation of NF-kappaB , p38 [MAPK] , and caspase independent cell death . Positive_regulation MAPK14 TNF 18287248 1896526 Flavopiridol suppresses induced *activation* of activator protein-1 , c-Jun N-terminal kinase , p38 [mitogen activated protein kinase (MAPK)] , p44/p42 MAPK , and Akt , inhibits expression of antiapoptotic gene products , and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells . Positive_regulation MAPK14 TNF 18314542 1931907 P < 0.05 ) , and MKP-1 up-regulation was temporally related to the inhibition of *induced* p38 [MAPK] phosphorylation . Positive_regulation MAPK14 TNF 18336852 1912241 *stimulated* phosphorylation of p42/p44 [MAPK] and JNK were attenuated by pretreatment with the inhibitors U0126 and SP600125 or transfection with dominant negative mutants of DeltaERK and DeltaJNK . Positive_regulation MAPK14 TNF 18364436 1912769 We , for the first time , demonstrate that binding of staphylococcal enterotoxin B to MHC-II results in activation of TNF-alpha converting enzyme , epidermal growth factor receptor , [p38MAPK] , and NF-kappaB *inducing* biphasic production . Positive_regulation MAPK14 TNF 18443205 1938527 Conversely , *induced* increases in insulin receptor substrate-1 serine phosphorylation ( Ser ( 312 ) ) , Jun NH ( 2 ) -terminal kinase phosphorylation , and extracellular signal related kinase-1/2 [mitogen activated protein kinase (MAPK)] phosphorylation were unaltered by siRNA mediated IKKbeta reduction . Positive_regulation MAPK14 TNF 18518937 1971921 Although Cot/Tpl2 was phosphorylated in IRI and in the cultured tubular epithelial cells (TEC) after stimulation with LPS and hydrogen peroxide , there were no significant differences in terms of production , neutrophil infiltration or [MAPK] *activation* between Cot/Tpl2 ( +/+ ) and Cot/Tpl2 ( -/- ) mice . Positive_regulation MAPK14 TNF 18636175 1937271 Furthermore , glucosamine inhibited the *induced* phosphorylation of [p38MAPK] and NF-kappaB p65 , and the nuclear translocation of NF-kappaB in the cells . Positive_regulation MAPK14 TNF 18653803 1960518 PMA stimulated nSMase2 translocation was independent of p38 MAPK , and neither PKC inhibitors nor small interfering RNA had significant effects on *stimulated* p38 [MAPK] activation , indicating that PKC-delta does not act through p38 MAPK in regulating nSMase2 . Positive_regulation MAPK14 TNF 18710428 2028202 As for the signalling pathway , stimulation *led* to the phosphorylation of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and translocation of nuclear factor kappaB (NF-kappaB) ( p65 ) into the nuclei . Positive_regulation MAPK14 TNF 18710428 2028225 These data suggest that interaction *leads* to the phosphorylation of Erk1/2 and [p38MAPK] and nuclear translocation of NF-kappaB , which is closely associated with the production and activation of MMP-9 in cultured CC cells of HuCTT-1 and CCKS-1 . Positive_regulation MAPK14 TNF 18768892 1957222 Consistently , Nod2-null macrophages tolerant to LPS and MDP showed enhanced production of and IL-6 as well as increased NF-kappaB and [MAPK] *activation* in response to the dipeptide KF1B , the Nod1 agonist . Positive_regulation MAPK14 TNF 18948845 2053241 Hypertonic saline did not alter *induced* p38 [mitogen activated protein kinase] phosphorylation or constitutive vascular endothelial growth factor expression , suggesting that the observed inhibition is not a generalized suppression of protein phosphorylation or cellular function . Positive_regulation MAPK14 TNF 19100731 2031222 at 30 ng/ml significantly *increased* phosphorylation of receptor tyrosine kinase ( 175 kDa ) and p42 [mitogen activated protein (MAP) kinase] . Positive_regulation MAPK14 TNF 19130554 2025301 Stimulation of HIMEC with *triggered* phosphorylation of the [MAPK] , and up-regulation of VCAM-1 , FKN and ICAM-1 . Positive_regulation MAPK14 TNF 19234337 2079511 Analysis of downstream signals showed that inhibition of NAD(P)H oxidase partially inhibited NF-kappaB activation but did not reduce CCL2 mRNA stability or prevent *induced* phosphorylation of [p38MAPK] . Positive_regulation MAPK14 TNF 19275968 2072845 *stimulated* the phosphorylation levels of p38 [MAPK] , JNK , ERK1/2 and Akt in vascular endothelial cells . Positive_regulation MAPK14 TNF 19289468 2073039 The requirement for MADD was highly specific for *induced* activation of [MAPK] but not the related JNK and p38 kinases . Positive_regulation MAPK14 TNF 19371952 2081763 Of note , the IFN-gamma plus *stimulated* activation of p38 [MAPK] was suppressed following incubation with forskolin or DBcAMP alone . Positive_regulation MAPK14 TNF 19410630 2089696 By transfection of TAK1 siRNA , *induced* phosphorylation of IkappaBalpha , JNK1/2 , and [p38MAPK] , as well as IL-6 or IL-8 expression , were repressed . Positive_regulation MAPK14 TNF 19427347 2106795 *induced* the phosphorylation of p38 [mitogen activated protein (MAP) kinase] , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation MAPK14 TNF 19429670 2106865 Ang II and clearly *enhanced* ERK and [p38MAPK] phosphorylation . Positive_regulation MAPK14 TNF 19563733 2122009 Finally , EZS inhibited *induced* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phosphorylation . Positive_regulation MAPK14 TNF 19648110 2138332 This correlates with reduced *stimulated* p38 [MAPK] phosphorylation . Positive_regulation MAPK14 TNF 19648110 2138347 Repression of *induced* p38 [MAPK] phosphorylation , NF-kappaB dependent transcription , and IL-8 expression by dexamethasone are sensitive to transcriptional or translational inhibitors . Positive_regulation MAPK14 TNF 19648110 2138418 Thus , MKP-1 attenuates *dependent* activation of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Positive_regulation MAPK14 TNF 19648110 2138445 Small interfering RNA knockdown of dexamethasone induced MKP-1 expression partially reverses the repression of *activated* p38 [MAPK] , demonstrating that MKP-1 participates in the dexamethasone dependent repression of this pathway . Positive_regulation MAPK14 TNF 19788916 2163923 Tumor necrosis factor ( ) and H ( 2 ) O ( 2 ) *activate* [mitogen activated protein kinase (MAPK)] in SH-SY5Y cells within 5 min and this activation is completely blocked by DLPC ( 12 microM ) . Positive_regulation MAPK14 TNF 19877072 2160712 CpdA also displayed profound effects on *induced* [MAPK] activation . Positive_regulation MAPK14 TNF 19877072 2160729 In sharp contrast , DEX did not affect induced IKK phosphorylation , IkappaBalpha degradation , p65 nuclear translocation , or [MAPK] *activation* in RA FLS . Positive_regulation MAPK14 TNF 19889458 2197304 Calpain inhibition induces random migration in TNF-alpha stimulated cells and prevents the generation of reactive oxygen species , but does not alter mediated *activation* of p38 [MAPK] and ERK MAPK . Positive_regulation MAPK14 TNF 20231691 2237859 TNF-alpha treatment resulted in the phosphorylation of p38 MAPK and its downstream target , MAPK activated protein kinase-2 , but IFN-gamma did not affect the levels of [MAPK] and MAPK activated protein kinase-2 phosphorylation *induced* by . Positive_regulation MAPK14 TNF 20489729 2327421 *induced* activation of p38 [MAPK] and the production of inducible nitric oxide synthase were suppressed in ASK1-deficient Müller glial cells . Positive_regulation MAPK14 TNF 20646342 2292550 Effects of budesonide on P38 [MAPK] activation , apoptosis and IL-8 secretion , *induced* by and Haemophilus influenzae in human bronchial epithelial cells . Positive_regulation MAPK14 TNF 20646342 2292578 induced a significant *increase* in p38 [MAPK] phosphorylation . Positive_regulation MAPK14 TNF 20693316 2351479 In four of the six donors , basal and *induced* ERK and p38 [MAPK] activation were higher in ASMA than ASMNA cells . Positive_regulation MAPK14 TNF 20696856 2351510 Surprisingly , replenishment with exogenous GSH normalizes both *dependent* NF-?B as well as [MAPK] signaling and rescues hepatocytes from FKB induced death . Positive_regulation MAPK14 TNF 20951126 2364959 Taken together , this study provided first evidence demonstrating that TRAIL- , , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK14 TNF 21123734 2377723 The ability of CO to inhibit *induced* ERK1/2 and p38 [MAPK] activities in an Akt dependent manner appears to be the key element in ROS dependent survival of endothelial cells during TNF-a mediated brain inflammatory disease . Positive_regulation MAPK14 TNF 21181166 2499611 IL-1ß and *activated* the intracellular mitogen activated protein kinases ( MAPKs ) : p44/42 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) as well as nuclear factor-?B ( NF-?B ) in osteoblasts . Positive_regulation MAPK14 TNF 21285293 2425726 Inhibitors of NADPH oxidase and/or p47phox siRNA diminished ROS production and COX-2 expression as well as phosphorylation of p38 [mitogen activated protein kinase] ( p38MAPK ) and Akt *mediated* either by AS serum or by . Positive_regulation MAPK14 TNF 21336587 2457990 Effects of preconditioning with sevoflurane on *induced* permeability and activation of p38 [MAPK] in rat pulmonary microvascular endothelial cells . Positive_regulation MAPK14 TNF 21422246 2416769 Interestingly , all PHA-L ( high ) DCs displayed a strongly reduced responsiveness to induced [p38-MAPK] *activation* compared with PHA-L ( low ) DCs , indicating differences in PHA-L binding capacities between DCs with different inflammatory properties . Positive_regulation MAPK14 TNF 21422246 2416783 Moreover , hybrid-type , but not complex-type , N-glycans are required for induced [p38-MAPK] *activation* and subsequent phenotypic maturation of BMDCs ( MHC-II , CD86 , CCR7 upregulation ) . Positive_regulation MAPK14 TNF 21520062 2423122 Here , we report that *induced* cPLA(2) protein and mRNA expression , PGE ( 2 ) production , and phosphorylation of p42/p44 MAPK , p38 [MAPK] , and JNK1/2 , which were attenuated by pretreatment with a ROS scavenger [ N-acetyl-L-cysteine , ( NAC ) ] and the inhibitors of NADPH oxidase [ apocynin (APO) and diphenyleneiodonium chloride ( DPI ) ] , MEK1/2 ( U0126 ) , p38 MAPK ( SB202190 ) , and JNK1/2 ( SP600125 ) or transfection with siRNA of Nox2 , p47(phox) , MEK1 , p42 , p38 , or JNK2 . Positive_regulation MAPK14 TNF 21545687 2554381 significantly *induced* phosphorylation of p38 [MAPK] , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation MAPK14 TNF 21894146 2510873 Vehicle and untreated NTN exhibited heavy proteinuria and glomerular thrombosis at 24 h with P-selectin and fibrin immunostaining within capillaries , glomerular macrophage and T cell infiltration , *activation* of JNK and p38 [MAPK] signalling , and upregulation of glomerular mRNA levels of pro-inflammatory molecules ( , NOS2 , MMP-12 and CCL2 ) . Positive_regulation MAPK14 TNF 22002864 2526328 These results suggest that H ( 2 ) O ( 2 ) -induced secretion of *increases* apoptosis of cardiac myocytes through ROS dependent activation of p38 [MAPK] . Positive_regulation MAPK14 TNF 22227193 2544577 Casuarinin significantly inhibited *induced* activation of NF-?B , STAT1 , and p38 [MAPK] . Positive_regulation MAPK14 TNF 22230399 2519477 KMUP-1 inhibited *induced* iNOS and U46619 induced PDE-5A and phospho-p38 [MAPK] in normoxia , confirming its anti-proinflammatory action . Positive_regulation MAPK14 TNF 22250084 2551212 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Positive_regulation MAPK14 TNF 22343222 2617817 Using immunohistological techniques , we showed a higher epithelial expression of , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator [protein-1/mitogen activated protein kinase] signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation MAPK14 TNF 22525504 2522573 *up-regulated* the phosphorylation levels of p38 [MAPK] and increased the translocation of NF-kB p65 protein into the nucleus , also proved by immunofluorescence staining . Positive_regulation MAPK14 TNF 22526394 2595914 also *increased* the production of inducible nitric oxide synthase (iNOS) , nitric oxide ( NO ) , and intercellular adhesion molecule 1 ( ICAM-1 ) through activation of p38 [mitogen activated protein kinase (MAPK)] from HT-29 cells . Positive_regulation MAPK14 TNF 22773691 2659903 *induced* activation of p38 [MAPK] and NF-?B was attenuated by miR-140-3p mimic . Positive_regulation MAPK14 TNF 22819264 2646096 CORM-2 inhibited *induced* activation of p38 [MAPK] , ERK1/2 , JNK , and NF-?B signaling pathways in HUVECs . Positive_regulation MAPK14 TNF 22947346 2678662 *induced* phosphorylated p38 [mitogen activated protein kinase] levels were increased in ASMCs from patients with severe asthma compared with those from patients with nonsevere asthma and nonasthmatic subjects , whereas TNF-a induced phosphorylated c-Jun N-terminal kinase and phosphorylated extracellular signal related kinase levels were increased in all asthmatic groups . Positive_regulation MAPK14 TNF 22988345 2674356 The EGF receptor and HER2 participate in *dependent* [MAPK] activation and IL-8 secretion in intestinal epithelial cells . Positive_regulation MAPK14 TNF 22988345 2674384 As the epidermal growth factor receptor (EGFR) is a known transducer of proliferative signals and a potent activator of MAPKs , we hypothesized that the EGFR participates in *dependent* [MAPK] activation and IL-8 secretion by intestinal epithelial cells ( IECs ) . Positive_regulation MAPK14 TNF 23071098 2720907 Mixed-effects modeling analysis of our data was vital for ascertaining that IL-1a and TGF-a treatment increased the activities of more pathways than IL-6 and TNF-a and that TGF-a and *increased* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phospho-protein levels in a synergistic manner . Positive_regulation MAPK14 TNF 23142559 2722787 Western blot analysis revealed that pilocarpine and physostigmine enhanced the *induced* phosphorylation of ERK1/2 and p38 [MAPK] and the degradation of I?Ba . Positive_regulation MAPK14 TNF 23333920 2758385 Interestingly , IL-27 promoted the basal and enhanced *induced* phosphorylation of p38 [MAPK] and Akt , but not I?Ba . Positive_regulation MAPK14 TNF 23353699 2754241 We further demonstrated that markedly *stimulated* p38 MAPK , p42/p44 [MAPK] , and JNK1/2 phosphorylation via a c-Src/EGFR , PDGFR/PI3K/Akt pathway . Positive_regulation MAPK14 TNF 23354775 2770471 p38a [mitogen activated protein kinases (MAPK)] may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , , interleukin-1ß , and oxidative stress . Positive_regulation MAPK14 TNF 23664593 2838384 sFGL2 secretion by CD4 ( + ) T cells can be *induced* with and IFN-? stimulation through [MAPK] signaling in renal allograft AR . Positive_regulation MAPK14 TNF 23861542 2817233 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Positive_regulation MAPK14 TNF 23884101 2821469 Furthermore , P. vulgaris extract suppressed *induced* phosphorylation of p38 [mitogen activated protein kinase (MAPK)] and extracellular signal regulated kinase ( ERK ) . Positive_regulation MAPK14 TNF 23935096 2840767 In contrast , loss of SK1 prevented *induced* phosphorylation of p38 [MAPK] , and inhibition of p38 MAPK , like SK1 knockdown , also potentiates RANTES induction . Positive_regulation MAPK14 TNF 24069158 2846994 We showed that markedly *stimulated* p42/p44 [MAPK] , p38 MAPK , and JNK1/2 phosphorylation which were attenuated by their respective inhibitors . Positive_regulation MAPK14 TNF 24080497 2902540 Consistently , DUSP1 promotes apoptosis and decreases NF-?B activity in cells in which p38 [MAPK] is *induced* by treatment . Positive_regulation MAPK14 TNF 24089494 2848151 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed receptor 1 and *requires* activation of p38 [MAPK] , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation MAPK14 TNF 24361597 2911246 We further demonstrated that *stimulated* ERK1/2 , p38 [MAPK] , and JNK1/2 phosphorylation via a c-Src dependent PDGFR/PI3K/Akt pathway . Positive_regulation MAPK14 TNF 24378531 2911774 TRAF2 has been previously reported to be required for induced *activation* of p38 [MAPK] . Positive_regulation MAPK14 TNF 24441870 2922934 We showed that markedly *stimulated* Jak2 , PDGFR , Akt , and p42/p44 [MAPK] phosphorylation , which were attenuated by their respective inhibitors . Positive_regulation MAPK14 TNF 24441870 2922952 In addition , *induced* p42/p44 [MAPK] phosphorylation was reduced by AG1296 or LY294002 . Positive_regulation MAPK14 TNF 24441870 2922988 On the other hand , could *induce* Akt and p42/p44 [MAPK] translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation MAPK14 TNF 24446489 2912939 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Positive_regulation MAPK14 TNF 24489443 2884793 Finally , by investigating the intracellular pathways involved in promoting the VEC release of cytokines/chemokines , which are targeted by natural anti-inflammatory compounds , we documented that aLipoic acid significantly counteracted *induced* NF-?B and [p38/MAPK] activation while the effects of Ginkgo biloba appeared to be predominantly mediated by Akt . Positive_regulation MAPK14 TNF 24750790 2936572 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas and NO production *required* all three [MAPK] . Positive_regulation MAPK14 TNF 7689564 225765 *induced* activation and increased tyrosine phosphorylation of [mitogen activated protein (MAP) kinase] in human fibroblasts . Positive_regulation MAPK14 TNF 7689564 225778 *induced* activation of [MAPK] was demonstrated by its enhanced ability to phosphorylate myelin basic protein in vitro and by a characteristic shift in the electrophoretic mobility of MAPK proteins . Positive_regulation MAPK14 TNF 7722327 301758 *induces* tyrosine phosphorylation of [mitogen activated protein kinase] in adherent human neutrophils . Positive_regulation MAPK14 TNF 7722327 301784 PMN pretreatment with genistein , a tyrosine kinase inhibitor , inhibited the *induced* increase in tyrosine phosphorylation and [MAPK] activity . Positive_regulation MAPK14 TNF 8626494 360277 Inhibition of induced p42/p44 [mitogen activated protein kinase] *activation* by sodium salicylate . Positive_regulation MAPK14 TNF 8626494 360291 *activates* both p42 and p44 [mitogen activated protein kinases (MAPK)] in human FS-4 fibroblasts , cells for which TNF is mitogenic . Positive_regulation MAPK14 TNF 8626494 360304 We now show that *activates* p42 [MAPK] in two cell lines whose growth is inhibited by TNF . Positive_regulation MAPK14 TNF 8626494 360319 We now show that neither phorbol ester-sensitive protein kinase C nor Gialpha link TNF to p42/p44 MAPK activation , because pretreatment of FS-4 cells with phorbol ester to down-regulate protein kinase C or pretreatment with pertussis toxin to block Gialpha does not inhibit p42/p44 [MAPK] *activation* by . Positive_regulation MAPK14 TNF 8626494 360342 To further analyze MAPK activation in FS-4 cells , we compared p42/p44 [MAPK] *activation* by and epidermal growth factor (EGF) . Positive_regulation MAPK14 TNF 8626494 360364 Elucidation of the mechanism whereby sodium salicylate blocks *induced* p42/p44 [MAPK] activation may help to clarify TNF activated signaling pathways . Positive_regulation MAPK14 TNF 8662702 367183 additionally *caused* rapid p38 and JNK-1 [mitogen activated protein kinase] activation and efficient NF-kappaB translocation , which could not be achieved even by high levels of ceramide . Positive_regulation MAPK14 TNF 9106254 424415 The increases in [MAPK] *induced* by and IL-1 were similar to the increases induced by PMA and PDGF-AB . Positive_regulation MAPK14 TNF 9106254 424441 Our findings indicate that and IL-1 activate parallel signal transduction pathways in human neuroma fibroblasts , and that they are relatively stronger *activators* of [MAPK] than of SAPK . Positive_regulation MAPK14 TNF 9315666 456101 , an inhibitor of insulin stimulated adipogenesis , *activated* [MAPK] in 3T3-L1 cells . Positive_regulation MAPK14 TNF 9439626 482870 *increased* ERK1 and ERK2 [MAPK] phosphorylation . Positive_regulation MAPK14 TNF 9439626 482896 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic effect of *requires* protein tyrosine phosphorylation and [MAPK] activation . Positive_regulation MAPK14 TNF 9593119 505486 The CAZ released endotoxin was similar to purified LPS with respect to the following biological activities in LPS-responsive C3H/HeN mice and LPS-hyporesponsive C3H/HeJ mice : lethal toxicity in GalN sensitized mice , in vitro induction of and NO production by macrophages , and [mitogen activated protein kinase] *activation* in macrophages . Positive_regulation MAPK14 TNF 9766635 538510 Our data suggest that and GM-CSF *activate* ERKs and p38 [MAPK] by different signal transduction pathways . Positive_regulation MAPK14 TNF 9770326 538803 Furthermore , *induction* of p42/p44 ERK and [p38-MAPK] phosphorylation , c-jun kinase activation , and IkappaBalpha degradation were normal . Positive_regulation MAPK14 TNF 9883899 558209 *Activation* of p42/p44 mitogen activated protein kinases (MAPK) and p38 [MAPK] by is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation MAPK14 TNF 9883899 558224 Here , we demonstrate that is *sufficient* to activate p42/p44 [MAPK] and p38 MAPK . Positive_regulation MAPK14 TNF 9930718 588838 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Positive_regulation MAPK14 TNF 9931102 588905 ( 100 U/mL ) transiently *activated* [MAPK] with a maximal induction 10 minutes after stimulation that returned to baseline levels by 2 hours after treatment . Positive_regulation MAPK14 TNF 9931102 588918 PD98059 also blocked *stimulated* [MAPK] activation in a concentration dependent manner , which is consistent with its inhibition of TNF-alpha directed migration . Positive_regulation MAPK14 TNF 9931102 588931 To identify which TNF-alpha receptor is involved in *induced* [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Positive_regulation MAPK14 TNF 9931102 588957 VSMC express both receptors , but induced [MAPK] *activation* was inhibited only by the TNF-R1 antibody . Positive_regulation MAPK14 TNF 9931102 588983 Both TRO and RSG inhibited migration , but neither attenuated *induced* [MAPK] activation , indicating that their antimigration activity was exerted downstream of MAPK . Positive_regulation MAPK14 TNFSF10 12969966 1185572 Among the intracellular pathways investigated , significantly *stimulated* the extracellular signal regulated kinase 1/2 ( ERK1/2 ) but not the [p38/mitogen activated protein kinase (MAPK)] or the c-Jun NH2-terminal kinase (JNK) pathway . Positive_regulation MAPK14 TNFSF10 20951126 2364960 Taken together , this study provided first evidence demonstrating that , TNF-a- , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK14 TNFSF10 21152872 2373394 Taken together , we show herein that the upstream molecule of the induced [MAPK] *activation* is MEKK , as opposed to ASK1 , via the mediation of its signal through JNK/p38 in a caspase-8 dependent manner . Positive_regulation MAPK15 ADRB2 11018034 752784 induced p38 [MAPK] *activation* is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes . Positive_regulation MAPK15 ADRB2 12509508 1038729 beta-Arrestin 1 is required for internalization and [mitogen activated protein (MAP) kinase] *activation* by the . Positive_regulation MAPK15 ADRB2 19047375 2023478 Hematopoietic protein tyrosine phosphatase mediates *induced* regulation of p38 [mitogen activated protein kinase] in B lymphocytes . Positive_regulation MAPK15 ADRB2 9038193 415359 In the present work , we report that stimulation of the A2A-adenosine receptor and of the *activates* [mitogen activated protein kinase] ( MAP kinase ) in human endothelial cells based on the following criteria : adenosine analogues and beta-adrenergic agonists cause an ( i ) increase in tyrosine phosphorylation of the p42 isoform and to a lesser extent of the p44 isoform of MAP kinase and ( ii ) stimulate the phosphorylation of myelin basic protein by MAP kinase; (iii) this is accompanied by a redistribution of the enzyme to the perinuclear region . Positive_regulation MAPK15 ADRB2 9363896 462902 We show that in HEK293 cells , *stimulation* of [mitogen activated protein (MAP) kinase] by the is mediated by the betagamma subunits of pertussis-toxin-sensitive G proteins through a pathway involving the non-receptor tyrosine kinase c-Src and the G protein Ras . Positive_regulation MAPK15 ALOX5 11807011 903489 In contrast , stress induced product formation and translocation of <5-LO> , as well as *activation* of p38 [MAPK] , occurred also after Ca ( ++ ) depletion . Positive_regulation MAPK15 ALOX5 21200133 2391676 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Positive_regulation MAPK15 ANGPT1 12039842 954273 Accordingly , ephrinB2 inhibited VEGF- and *induced* [Ras-MAPK] activities , whereas ephrinB2 did not alter VEGF induced Flk phosphorylation or Ang1 induced Tie2 phosphorylation . Positive_regulation MAPK15 ANGPT1 12213710 985618 Both VEGF and *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 [MAPK] . Positive_regulation MAPK15 ANGPT1 12213726 985673 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of and Ang-2 as well as the *activation* of [MAPK] , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation MAPK15 ANGPT1 16061664 1439063 *activated* [mitogen activated protein kinase (MAPK)] and phosphoinositide 3-kinase (PI3K) in IBE cells and HUVECs . Positive_regulation MAPK15 ANGPT1 16679392 1612144 Pretreatment with either DPI or apocynin also significantly attenuated *induced* Akt and p44/42 [MAPK] phosphorylation . Positive_regulation MAPK15 ANGPT1 16679392 1612160 Using mouse heart microvascular endothelial cells from wild-type ( WT ) mice and mice deficient in the p47(phox) component of NADPH oxidase ( p47 ( phox-/- ) ) , we found that although *stimulated* intracellular ROS , Akt and p42/44 [MAPK] phosphorylation , and cell migration in WT cells , the responses were strikingly suppressed in cells from the p47 ( phox-/- ) mice . Positive_regulation MAPK15 ANGPT1 20072135 2235281 *promoted* skin cell metabolism/viability , adhesion , and akt and [MAPK] ( p42/44 ) activations . Positive_regulation MAPK15 ANO1 22564524 2619156 *induces* [MAPK] and contributes directly to tumorigenesis and cancer progression . Positive_regulation MAPK15 CAPN8 21543591 2424033 Downstream , an Aß-mediated rise in p38 [mitogen activated protein kinase (MAPK)] activation was followed by downregulation of cAMP response element binding protein , and LTP impairment was *prevented* by inhibitors of p38 MAPK or . Positive_regulation MAPK15 CAPN8 24416390 2900901 Treatment with glutamate leads to early activation of NMDAR , which in turn leads to *mediated* cleavage of striatal enriched protein tyrosine phosphatase ( STEP ) and subsequent activation of p38 [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK15 CCL17 23711854 2792879 IL-33 induced the production of thymus and activation regulated and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 [MAPK] . Positive_regulation MAPK15 CCND1 11004713 734988 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping [ERK-MAPK] activation and c-Fos and *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation MAPK15 CCND1 12654183 1072978 [MAPK] may *induce* overexpression of protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation MAPK15 CCND1 15634644 1349548 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 [mitogen activated protein kinase] , and down-regulation of . Positive_regulation MAPK15 CCND1 16522728 1531452 We conclude that incretin induced beta-cell replication is dependent on cAMP/PKA , p42 [MAPK] and PI3K activities , which may *involve* transcriptional induction of . Positive_regulation MAPK15 CCND1 9537433 497546 Furthermore , in 25 of 26 cases of HCC which genomic DNA was available , 22 cases without genomic DNA amplification exhibited positive correlation , not only between protein expression of c-Fos and , but also between [MAPK/ERK] *activation* and cyclin D1 expression . Positive_regulation MAPK15 CD14 15625444 1349231 LPS interacts with the cell surface receptor , which generates transmembrane signals through Toll-like protein 4 *leading* to [mitogen activated protein kinase (MAPK)] p38 activation , cytokine synthesis , PMN beta2-integrin expression and oxidative burst . Positive_regulation MAPK15 CHI3L1 23755018 2797722 In addition , *induces* [FAK-MAPK] signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation MAPK15 CHI3L1 23972995 2836231 We also demonstrate that *activates* macrophage [mitogen activated protein kinase] , protein kinase B/AKT , and Wnt/ß-catenin signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation MAPK15 CLU 23051594 2702791 FOXL2 directly stimulates the Clu gene promoter , and we show that PTTG triggers ataxia telangiectasia mutated [kinase/IGF-I/p38MAPK] DNA damage/chromosomal instability signaling , which in turn also *induces* expression . Positive_regulation MAPK15 CTGF 11732999 885257 *induces* chondrocyte differentiation through a p38 [mitogen activated protein kinase] ( p38MAPK ) , and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase ( ERK ) . Positive_regulation MAPK15 CTGF 11732999 885270 In the proliferation phase , *induced* a approximately fivefold increase in the phosphorylation of p44/42 [MAPK/ERK] and a approximately twofold increase in that of p38 MAPK in an in vivo kinase assay . Positive_regulation MAPK15 CTGF 12218048 1012156 The inhibition of *induced* p42/44 [MAPK] or phosphatidylinositol 3-kinase (PI3K)/protein kinase B pathway activities abrogated the induction of fibronectin expression . Positive_regulation MAPK15 CTGF 16408113 1513469 *enhanced* the mRNA expression and protein release of fractalkine , MCP-1 , and RANTES , the expression of phospho ( P ) -p42/44 [mitogen activated protein kinase (MAPK)] , P-phosphoinositide 3-kinase (PI3-K) , P-Akt , and activity of nuclear factor-kappaB (NF-kappaB) in mesangial cells . Positive_regulation MAPK15 CTGF 16408113 1513490 P-p42/44 MAPK blockade inhibited the *induced* expression of P-p42/44 [MAPK] but not NF-kappaB , and partially decreased the levels of the above chemokines in supernatants . Positive_regulation MAPK15 CTGF 16522717 1531320 ( 3 ) *stimulated* dose dependent HSC adhesion and activity of p42/p44 [mitogen activated protein kinase] , the latter of which was antagonized by blocking the activity of focal adhesion kinase . Positive_regulation MAPK15 CTGF 16938382 1654119 No single module , but a mixture of the 4 modules provoked a significant activation of p38 [MAPK] in HCS-2/8 cells , which was *activated* by the full-length . Positive_regulation MAPK15 CTGF 19038999 2023073 Interestingly , CCN2-BMP-2 did not affect the *induced* phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Positive_regulation MAPK15 EDN2 12193071 980913 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Positive_regulation MAPK15 EDN2 12475899 1037709 *induced* a rapid phosphorylation of the [mitogen activated protein kinase (MAPK)/ERK] and increased collagen I gene activity in freshly isolated aortas . Positive_regulation MAPK15 EDN2 1280103 203021 rapidly *stimulates* [mitogen activated protein kinase] activity in rat mesangial cells . Positive_regulation MAPK15 EDN2 12855582 1149833 also *induced* the activation of p42/44 [mitogen activated protein kinase (MAPK)] in DCs . Positive_regulation MAPK15 EDN2 7509933 241588 *stimulates* [mitogen activated protein kinase] p42 activity through the phosphorylation of the kinase in rat mesangial cells . Positive_regulation MAPK15 EDN2 7849246 286712 *stimulates* [mitogen activated protein kinase] activity in mesangial cells through ETA . Positive_regulation MAPK15 EDN2 7943276 276379 has been shown to *activate* [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK15 EDN2 8836145 386153 In bovine airway smooth-muscle cells platelet derived growth factor ( PDGF ) and ( Et-1 ) *stimulate* sustained and comparable activation of [mitogen activated protein kinase] ( MAP kinase ) but display very different mitogenic efficacies , with PDGF inducing 50 times more DNA synthesis than Et-1 . Positive_regulation MAPK15 EFNB1 15502157 1347555 Further downstream of the signaling pathway , stimulation *led* to increased LAT ( linker for activation of T-cells ) phosphorylation and p44/42 and p38 [MAPK] activation . Positive_regulation MAPK15 EPHB2 10601128 574184 Tumor necrosis factor-alpha (TNF-alpha) alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only . Positive_regulation MAPK15 EPHB2 10872747 707006 Pre-treatment of the cells with PD98059 , a selective pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation MAPK15 EPHB2 11083274 750484 Tumor necrosis factor alpha , interleukin-1 (IL-1) , and IL-6 were the major inducers of , JNK , and p38 [MAPK] *activation* in cultured human synovial cells . Positive_regulation MAPK15 EPHB2 12386816 999745 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 [MAPK] and a biphasic *activation* of . Positive_regulation MAPK15 EPHB2 12403788 1036155 SB203580 , a p38 [MAPK] *inhibitor* , and PD98059 , an inhibitor , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation MAPK15 EPHB2 12486127 1056303 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain *had* little effect on basal Erk [MAPK] activation . Positive_regulation MAPK15 EPHB2 12511425 1070719 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation MAPK15 EPHB2 12801927 1120227 GE2 stimulation *induced* phosphorylation , whereas it did not alter the phosphorylation of c-Jun N-terminal kinase or p38 [MAPK] . Positive_regulation MAPK15 EPHB2 12832293 1105571 Exposure to E. coli DNA resulted in phosphorylation of ERK 1/2 [MAPK] and inhibitors of activity ( PD98059 , UO126 ) significantly *reduced* the evoked IL-8 production . Positive_regulation MAPK15 EPHB2 12878192 1115514 ( 2 ) the *activation* of JNK and p38 [MAPK] but not in embryonic fibroblasts ( MEFs ) derived from ASK1 knockout mice ( ASK1 ( -/- ) MEFs ) was depressed compared to MEFs derived from wild type mice ( ASK1 ( +/+ ) MEFs ) ; Positive_regulation MAPK15 EPHB2 14973553 1212435 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen activated protein kinase (MAPK)] signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation MAPK15 EPHB2 14998726 1216710 Furthermore , we found that PD98059 , an pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation MAPK15 EPHB2 15659876 1350283 The anabolic effect of TNF-alpha was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an . Positive_regulation MAPK15 EPHB2 16038626 1437391 SF significantly prevented Abeta induced increases in IL-1beta and p38 [MAPK] *activation* and also Abeta induced changes in and phospho-Akt/PKB expression levels . Positive_regulation MAPK15 EPHB2 17056059 1649522 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Positive_regulation MAPK15 EPHB2 17403539 1735929 Trauma-hemorrhage increased the production of IL-6 , IL-10 , IL-12 and TNF-alpha enhanced the expression of TLR4 , MyD88 as well as the *activation* of [MAPK] proteins ( p38 , and JNK ) in epidermal keratinocytes . Positive_regulation MAPK15 EPHB2 17416211 1777839 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK15 EPHB2 17464174 1731740 The mRNA and surface protein up-regulation of CCR1 and CCR2 in 9CRA stimulated cells were weakly blocked by the pretreatment of SB202190 , a p38 [MAPK] *inhibitor* , and PD98059 , an upstream inhibitor . Positive_regulation MAPK15 EPHB2 18164124 1869578 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 [MAPK] , but not by the *activation* of JNK , , and NF-kappaB pathway . Positive_regulation MAPK15 EPHB2 18266967 2000288 VEGF induced activation of p42 also *led* to the nuclear translocation of [MAPK/ERK1/2] . Positive_regulation MAPK15 EPHB2 18285354 1885388 Pre-treatment with the [MAPK] *inhibitors* SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( inhibitor ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation MAPK15 EPHB2 18338254 1938052 Interestingly , inhibition of by U0126 completely *prevented* artepillin C-induced p38 [MAPK] phosphorylation of PC12m3 cells . Positive_regulation MAPK15 EPHB2 18520049 1918655 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of , rather than by the *activation* of p38 [MAPK] , in the spinal cord . Positive_regulation MAPK15 EPHB2 18982426 2105740 These inhibitory effects were partially inhibited by SB203580 , a specific *inhibitor* of p38 [MAPK] , but not by PD98059 , a specific inhibitors of extracellular signal regulated kinase ( ) , and SP600125 , a specific inhibitor of c-Jun-N-terminal kinase (JNK) . Positive_regulation MAPK15 EPHB2 19189219 2113957 Moreover , EM1 treatment resulted in less activation of p38 [MAPK] and more *activation* of signaling in lipopolysaccharide stimulated DCs . Positive_regulation MAPK15 EPHB2 19276187 2051400 Treatment of cells with sphingosine induced suppression of and *activation* of p38 [MAPK] . Positive_regulation MAPK15 EPHB2 19429670 2106899 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either inhibitor , [p38MAPK] *inhibitor* or NF-kappaB inhibitor . Positive_regulation MAPK15 EPHB2 19522739 2103123 Treatment with [MAPK] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation MAPK15 EPHB2 19672126 2168057 A scratch wound assay of healing rates in SV40 immortalized human corneal epithelial cell line ( HCEC ) evaluated the relative contributions by p38 and and JNK [MAPK] signaling *activation* to wound healing . Positive_regulation MAPK15 EPHB2 20025124 2175494 Prior treatment of the cells with PD98059 , an kinase inhibitor or SB203580 , a [p38MAPK] *inhibitor* , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation MAPK15 EPHB2 20554538 2327617 The HNE enhanced Sp1 and NF-?B activities were attenuated by SB203580 , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , and PD98059 , an extracellular signal regulated kinase ( ) inhibitor , respectively . Positive_regulation MAPK15 EPHB2 21126656 2355781 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 [mitogen activated protein kinase] , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by . Positive_regulation MAPK15 EPHB2 21311676 2360016 Treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation MAPK15 EPHB2 21488184 2417955 Dexmedetomidine induced phosphorylation of JNK and p38 [MAPK] in rat aortic SMCs , but did not *induce* phosphorylation of . Positive_regulation MAPK15 EPHB2 21586573 2449661 Incubation of T cells with ESAT-6 induced phosphorylation and increased functional p38 [MAPK] activity , but not *activation* of or JNK . Positive_regulation MAPK15 EPHB2 21599960 2445716 In the present studies , induction of central sensitization as indicated by spinal dorsal horn [MAPK] *activation* , specifically and p38 phosphorylation , was assessed in the MIA-OA model . Positive_regulation MAPK15 EPHB2 23394443 2713226 When compared to hamsters bearing tumors that remained on the control diet , the buccal pouches of hamsters bearing tumors receiving turmeric showed the following results : ( 1 ) decreased cell proliferation ( diminished PCNA , cyclin D1 , and Bcl-2 ) and PCNA labelling index , ( 2 ) enhanced apoptosis ( increased Bax , caspase-3 , caspase-9 , and cytochrome c , and decreased survivin ) and apoptotic index , ( 3 ) decreased inflammation ( decreased Cox-2 ) , and ( 4 ) decreased [MAPK] *activation* ( and p-p38 ) . Positive_regulation MAPK15 EPHB2 23892041 2830317 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three [MAPK] *inhibitors* ( inhibitor PD98059 , JNK inhibitor SP600125 and p38 inhibitor SB203580 ) . Positive_regulation MAPK15 EPHB2 23914844 2840553 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 [MAPK] and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of , JNK , NF-?B . Positive_regulation MAPK15 EPHB2 23917355 2826007 Inhibition of Akt or activity *reduced* phosphorylation of STAT1 in Colon26L5-CUG2 cells whereas inhibition of p38 [MAPK] did not significantly decrease levels of STAT1 phosphorylation , indicating that cell proliferation signals may be involved in CUG2 mediated activation of STAT1 . Positive_regulation MAPK15 EPHB2 24225419 2897477 Therefore , by using the [MAPK] *inhibitors* SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific inhibitor ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation MAPK15 EPHB2 24297112 2894196 Following treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation MAPK15 F2R 16052512 1460020 The p38 and ERK1/2 [MAPK] signaling cascades were also *activated* by stimulation , whereas the SAPK/JNK pathway was unaffected . Positive_regulation MAPK15 F2R 16467309 1548143 and PAR-2 stimulation rapidly *activated* both ERK1/2 and [p38MAPK] , and pharmacological blockade of MEK with either PD98059 or U0126 or of p38MAPK by SB203580 or SB202190 strongly inhibited thrombin- and SLIGKV induced COX-2 expression and 6-keto-PGF1alpha formation . Positive_regulation MAPK15 F2R 21252088 2402880 In the present study , we show that FVIIa , upon binding to EPCR on endothelial cells , activates endogenous protease activated receptor-1 (PAR1) and induces mediated p44/42 [mitogen activated protein kinase (MAPK)] *activation* . Positive_regulation MAPK15 F2R 24052258 2867011 However , the distinct non-canonical tethered ligands unmasked by neutrophil elastase and proteinase-3 , as well as synthetic peptides with sequences derived from these novel exposed tethered ligands , selectively stimulated mediated [mitogen activated protein kinase] *activation* . Positive_regulation MAPK15 F2R 8635212 357807 These results support the notion that the *activates* [MAPK] through PKC dependent pathways and that the incremental activation of MAPK by TRAP over that induced by thrombin is the consequence of enhanced activation through the PKC limb of the phosphoinositide lipid pathway . Positive_regulation MAPK15 FAS 14576831 1156600 A more physiological inhibitor , the intracellular PP2A inhibitor protein I2 ( PP2A ) , protected transfected HeLa cells in a similar way from *mediated* apoptosis and induced activation of [MAPK] in I2 ( PP2A ) transfected cells . Positive_regulation MAPK15 FAS 15280387 1302527 We further demonstrate that this pro-apoptotic effect of CO was independent of reactive oxygen species production and involved inhibition in *induced* activation of the pro-survival ERK [MAPK] . Positive_regulation MAPK15 FAS 16507991 1529625 Here we show that binding of Fas ligand to *activates* p38 [MAPK] in CD8+ T cells and that activation of this pathway is required for Fas mediated CD8+ T-cell death . Positive_regulation MAPK15 FAS 19417161 2179805 GST-MDA-7 killing was , in parallel , dependent on inactivation of extracellular signal regulated kinase 1/2 and on *induced* p38 [mitogen activated protein kinase] and c-jun NH ( 2 ) -terminal kinase-1/2 signaling . Positive_regulation MAPK15 FAS 21613257 2454271 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Positive_regulation MAPK15 FAS 21975294 2492838 Caspase-8 activity has an essential role in mediated [MAPK] *activation* . Positive_regulation MAPK15 FAS 8977313 403341 IFN-alpha2 did not alter the *induced* activity of [Mitogen activated protein kinase (MAPK)] 1 and did not inhibit the Apo-1/Fas mediated proteolytic cleavage of ADP-ribosyltransferase , a substrate of Interleukin-beta1 converting enzyme ( ICE ) and homologues . Positive_regulation MAPK15 FHL1 23456229 2781810 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Positive_regulation MAPK15 FOXA1 22879989 2641674 An increase in IGFBP-3 , mediated by depletion of , *inhibited* phosphorylation of [MAPK] and Akt , and increased expression of the cell cycle regulators p21 and p27 . Positive_regulation MAPK15 FUT4 20506505 2307947 These data suggested that not only *activates* [MAPK] and PI3K/Akt signals , but also promotes the crosstalk among these signaling pathways . Positive_regulation MAPK15 GLP1R 21356521 2394810 activation by Exendin-4 ( Ex-4 ) *increased* PKA and [MAPK] activity and decreased phosphorylation of AMPK in NTS . Positive_regulation MAPK15 GPR115 10958680 724958 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK15 GPR115 11916960 944710 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK15 GPR115 9182581 434904 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on mediated *activation* of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK15 GPR115 9826186 549301 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK15 GPR132 10958680 724947 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK15 GPR132 11474113 841733 Activation of by LPC *increased* intracellular calcium concentration , induced receptor internalization , activated ERK [mitogen activated protein kinase] , and modified migratory responses of Jurkat T lymphocytes . Positive_regulation MAPK15 GPR132 11916960 944699 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK15 GPR132 9182581 434893 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK15 GPR132 9826186 549290 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK15 GPR87 10958680 725027 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK15 GPR87 11916960 944779 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK15 GPR87 9182581 434973 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK15 GPR87 9826186 549370 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK15 HBEGF 10544013 563918 also rapidly *activated* [MAPK] and induced cyclin D1 in mid-G1 with kinetics similar to TGFalpha . Positive_regulation MAPK15 HBEGF 11171084 783775 Both p42 [MAPK] activation and mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation MAPK15 HBEGF 15380451 1298456 *induced* phosphorylation of ERK , p38 [MAPK] and Akt , which were suppressed by ZD1839 . Positive_regulation MAPK15 HBEGF 17928891 1858619 We report that cellular stress with methyl-beta-cyclodextrin ( MBCD ) , a molecule that extracts membrane cholesterol and thereby disrupts the structure of lipid rafts , strongly *induces* the synthesis of ( HB-EGF ) in keratinocytes through the activation of p38 [mitogen activated protein kinase] . Positive_regulation MAPK15 HBEGF 18990151 2028903 *Activation* of [Erk/MAPK] by was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation MAPK15 HBEGF 19048624 2023711 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked MAPK signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 [MAPK] , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Positive_regulation MAPK15 HBEGF 19559571 2110499 *induced* phosphorylation of p42/p44 [MAPK] in a few minutes . Positive_regulation MAPK15 HBEGF 20739666 2345871 Moreover , *induced* a stronger and more sustained activation of both the [mitogen activated protein kinase] and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation MAPK15 HBEGF 24188029 2921060 Here , we show that *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , [Mapk/Erk] pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation MAPK15 HRH1 11959800 931436 1. Previous studies have shown that the *activates* p42/p44 [mitogen activated protein kinases (MAPK)] in DDT ( 1 ) MF-2 smooth muscle cells via a phosphatidylinositol 3-kinase (PI-3K) dependent pathway . Positive_regulation MAPK15 HRH1 17965772 1820333 is *required* for TCR mediated p38 [MAPK] activation and optimal IFN-gamma production in mice . Positive_regulation MAPK15 HRH1 17965772 1820348 Moreover , signaling at the time of TCR ligation was *required* for activation of p38 [MAPK] , a known regulator of IFN-gamma expression . Positive_regulation MAPK15 IFI27 16953232 1682549 RET2A mediated regulation of p18 and , but not of cyclins D1 and D2 , *requires* functional [mitogen activated protein kinase] signaling . Positive_regulation MAPK15 IL1B 10640438 577494 and TNF alpha also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK15 IL1B 10704772 673000 CPI-1189 inhibits *induced* [p38-mitogen activated protein kinase] phosphorylation : an explanation for its neuroprotective properties ? Positive_regulation MAPK15 IL1B 10775561 686639 *activated* p44/42 [MAPK] , and this activation was enhanced in the presence of N-acetyl-L-cysteine . Positive_regulation MAPK15 IL1B 10864897 705716 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK15 IL1B 10864897 705768 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by TNF-alpha and . Positive_regulation MAPK15 IL1B 10864897 705793 TNF-alpha- and *induced* [ ( 3 ) H ] -thymidine incorporation and phosphorylation of p42/p44 [MAPK] was completely inhibited by PD98059 ( an inhibitor of MEK1/2 ) , indicating that activation of MEK1/2 was required for these responses . Positive_regulation MAPK15 IL1B 10969830 728481 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Positive_regulation MAPK15 IL1B 11032891 740434 *induces* p38 [MAPK] phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation MAPK15 IL1B 11037878 741236 also *stimulated* phosphorylation of p38 [MAPK] , SAPK/JNK , and ATF-2 . Positive_regulation MAPK15 IL1B 11126408 759768 TNFalpha and IFNgamma potentiate *induced* [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK15 IL1B 11126408 759781 [Mitogen activated protein kinase (MAPK)] activity that is *induced* by has been suggested to signal nitric oxide dependent as well as nitric oxide independent beta-cell destructive pathways . Positive_regulation MAPK15 IL1B 11126408 759794 The aim of this study was to investigate if TNFalpha and IFNgamma signal through mitogen activated protein kinases in isolated rat islets of Langerhans and if they potentiate [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK15 IL1B 11126408 759807 Further , TNFalpha and IFNgamma were found to synergistically increase [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK15 IL1B 11399523 824254 Glucose potentiates *induced* p38 [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK15 IL1B 11509550 848347 Although and TNF-alpha each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK15 IL1B 11557585 861398 *activated* the three [mitogen activated protein kinase] ( extracellular signal regulated kinases 1 and 2 , c-Jun NH2-terminal kinase/stress activated protein kinase , and p38 ) and the Janus kinase (JAK)-signal transducer and activator of transcription pathways . Positive_regulation MAPK15 IL1B 11698472 878034 *induced* phosphorylation and activation of p38 [MAPK] and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation MAPK15 IL1B 11698472 878092 *induced* phosphorylation of ERK and JNK as well as p38 [MAPK] in human endothelial cells . Positive_regulation MAPK15 IL1B 11728947 884804 We showed a dramatic decrease in *induced* phosphorylation of p38 [MAPK] , not extracellular signal regulated kinases 1/2 or jun NH2-terminal kinase , in rat cultured mesangial cells by FR167653 . Positive_regulation MAPK15 IL1B 11775830 766429 Role of protein tyrosine kinase in *induced* activation of [mitogen activated protein kinase] in fibroblast-like synoviocytes of rheumatoid arthritis . Positive_regulation MAPK15 IL1B 11853544 913365 Interestingly , *induced* p38 [MAPK] activity was greatly enhanced in ( alg+ ) compared with ( alg- ) cells . Positive_regulation MAPK15 IL1B 12117921 964647 mRNA expression by neutrophils was not dependent on p38 MAPK , and p38 [MAPK] was not *activated* in neutrophils incubated with A. phagocytophila . Positive_regulation MAPK15 IL1B 12131776 966849 and TNF-alpha *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK15 IL1B 12139924 969391 Regarding intracellular signaling , *activated* the p38 [mitogen activated protein kinase (MAPK)] but not the p42/p44 MAPK and , when combined with growth factors , intensified p38 activation but inhibited the growth-factor induced p42/p44 activation . Positive_regulation MAPK15 IL1B 12356282 993810 *induced* p44/42 [mitogen activated protein kinase (MAPK)] activation was inhibited by the MAPK/extracellular signal regulated protein kinase ( MEK ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK15 IL1B 12417253 1012948 Sphondin ( 50 microM ) did not affect the *induced* activations of p44/42 [MAPK] , p38 MAPK , and JNK . Positive_regulation MAPK15 IL1B 12500176 1026681 These data suggest that the presence of retinal holes and may *lead* to activation of HGF , [mitogen activated protein kinases (MAPK)] , c-jun and extracellular matrix remodeling , resulting in proliferative and migratory cells in the wounded retina . Positive_regulation MAPK15 IL1B 12507586 1038416 In this study we evaluated the role of epigallocatechin-3-gallate ( EGCG ) , a green tea polyphenol which mimics its anti-inflammatory effects , in modulating the *induced* activation of [MAPK] 's in human chondrocytes . Positive_regulation MAPK15 IL1B 12649265 1080062 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant MKK6 or p38beta2 MAPK inhibited *induced* p38 [MAPK] activation , COX-2 gene expression , and PGE2 release . Positive_regulation MAPK15 IL1B 12727980 1086551 P38 [MAPK] phosphorylation was *increased* by in nondecidualized ESC , whereas the IL-1 beta induced increase was suppressed in the decidualized cells . Positive_regulation MAPK15 IL1B 12727980 1086565 Treatment with 8-bromo-cAMP reduced *induced* phosphorylation of p38 [MAPK] in nondecidualized ESC . Positive_regulation MAPK15 IL1B 12727980 1086578 In contrast , treatment with H89 , a protein kinase A inhibitor , reversed a reduction in *induced* p38 [MAPK] phosphorylation in the decidualized cells . Positive_regulation MAPK15 IL1B 12727980 1086593 The altered property of decidualized cells is thought to be caused by attenuation of *induced* p38 [MAPK] phosphorylation in a way that involves the activation of the cAMP/protein kinase A pathway . Positive_regulation MAPK15 IL1B 12882449 1116284 NAC ( 1 mM ) also decreased the *induced* activation of p38 [MAPK] . Positive_regulation MAPK15 IL1B 12952251 1137412 Using Western-blot analysis , no effect of cAMP was found on the *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK15 IL1B 12952251 1137426 No decrease was observed in *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK15 IL1B 14563491 1154855 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Positive_regulation MAPK15 IL1B 15039421 1251209 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of , and RIP2 dependent *activation* of NF-kappaB and p38 [MAPK] mediated by the caspase recruitment domain . Positive_regulation MAPK15 IL1B 15111866 1241221 We further demonstrated that p38 [MAPK] is *activated* by and PDGF with different kinetics and that p38 MAPK is required for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation MAPK15 IL1B 15208668 1281325 *induced* the activation of extracellular signal regulated kinases-1/2 and P38 [mitogen activated protein kinase (MAPK)] , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation MAPK15 IL1B 15341531 1291754 In accordance with these findings , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) , which was attenuated by U0126 , SB202190 , or SP600125 , respectively . Positive_regulation MAPK15 IL1B 15389584 1354314 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] and JNK which was attenuated by pretreatment with U0126 or SP600125 , respectively . Positive_regulation MAPK15 IL1B 15489374 1359418 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and JNK was attenuated by pretreatment with U0126 , SB-202190 , or SP-600125 , respectively . Positive_regulation MAPK15 IL1B 15755725 1403416 The inhibitory effect of on alpha ENaC expression was *mediated* by the activation of p38 [MAPK] in both rat and human ATII cells and was independent of the activation of alpha v beta6 integrin and transforming growth factor-beta . Positive_regulation MAPK15 IL1B 16033422 1436159 Intrathecal *leads* to a time dependent up-regulation of phosphorylated p38 ( p-p38 ) [MAPK] protein expression in the spinal cord 30-240 min following IL-1beta injection ( i.t. ) . Positive_regulation MAPK15 IL1B 16033422 1436173 However , pretreatment with a p38 MAPK inhibitor significantly reduced the *induced* p-p38 [MAPK] expression by 38-49 % , and nearly completely blocked the subsequent iNOS expression ( reduction by 86.6 % ) , NO production , and thermal hyperalgesia . Positive_regulation MAPK15 IL1B 16043966 1459729 Western blot analysis demonstrated that *increased* the activation of phosphorylated MEK and p38 [MAPK] in GH3 cells . Positive_regulation MAPK15 IL1B 16140882 1450799 *induced* phosphorylation of [p38-MAPK] , but not that of c-Jun-N-terminal kinase or extracellular regulated kinase , was most susceptible to inhibition by low doses of PFE , and the addition of PFE blocked the activity of p38-MAPK in a kinase activity assay . Positive_regulation MAPK15 IL1B 16141635 1454864 DHA stimulated both rapid and prolonged activation of p44/42 , but not p38 , [mitogen activated protein kinase (MAPK)] *induced* by and PMA . Positive_regulation MAPK15 IL1B 16153910 1455397 The kidney was analyzed for expression of tumor necrosis factor alpha , , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 [mitogen activated protein kinase] , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation MAPK15 IL1B 16452991 1611727 Western blots showed that and TNF-alpha *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK15 IL1B 16528573 1549423 The aim of this study was to investigate if Gadd45b prevents *induced* beta cell [MAPK] signalling and apoptosis . Positive_regulation MAPK15 IL1B 16645161 1604672 significantly *increased* the phosphorylation of p38 [MAPK] and cPLA(2) . Positive_regulation MAPK15 IL1B 16698013 1575649 JST ( 0.01-1 mg/ml ) also attenuated the expression of cyclooxygenase (COX)-2 and activation of p38 [MAPK] *induced* by and A beta ( 1-42 ) . Positive_regulation MAPK15 IL1B 16718462 1584904 A synthetic peptide , C3d , reported to bind NCAM , did not activate MAPK or Akt as reported in neurons but inhibited *induced* [MAPK] activity , thereby mimicking the effect of SU5402 . Positive_regulation MAPK15 IL1B 16718462 1584927 We suggest that NCAM signalling through FGFR is required for efficient IL-1beta pro-apoptotic signalling by facilitating induced [MAPK] *activation* downstream of the NF-kappaB-MAPK branching point . Positive_regulation MAPK15 IL1B 16718462 1584942 Further , these data identify a novel function of C3d as an inhibitor of NCAM induced FGFR activity and of *induced* [MAPK] activation in beta cells . Positive_regulation MAPK15 IL1B 16959849 1639692 *caused* an increase in the phosphorylation of ERK , but not [p38MAPK] or c-Jun N-terminal kinase . Positive_regulation MAPK15 IL1B 16964394 1611549 Inhibitors of p38 [MAPK] and/or JNK significantly suppressed VEGF secretion both in the *presence* and absence of , while inhibitors of COX-2 , ERK1/2 , and PI3-K did not . Positive_regulation MAPK15 IL1B 17208222 1695806 Thalidomide also suppressed *induced* p38 [mitogen activated protein kinase (MAPK)] activation , while a p38 MAPK inhibitor destabilized COX-2 mRNA and the cytoplasmic shuttling of HuR induced by IL-1beta . Positive_regulation MAPK15 IL1B 17311279 1719285 *stimulated* phosphorylation of p42/p44 MAPK , p38 [MAPK] , and JNK was attenuated by pretreatment with U0126 , SB202190 , SP600125 , or transfection with these dominant negative mutants of MEK , ERK , p38 and JNK , respectively . Positive_regulation MAPK15 IL1B 17390080 1716120 We have previously demonstrated that *induced* HBD-2 mRNA expression in A549 cells through activation of nuclear factor-kappaB (NF-kappaB) transcriptional factor as well as p38 [mitogen activated protein kinase (MAPK)] , c-Jun N-terminal kinase (JNK) , or phosphatidylinositol-3-kinase (PI3K) . Positive_regulation MAPK15 IL1B 17390080 1716157 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Positive_regulation MAPK15 IL1B 17390080 1716187 Triptolide inhibited *induced* [MAPK] phosphatase-1 expression at the transcriptional level and resulted in sustained phosphorylation of JNK or p38 MAPK , explaining the little effect of triptolide on IL-1beta induced phosphorylation of these kinases . Positive_regulation MAPK15 IL1B 17438131 1742751 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by TNF-alpha and , but not by ansiomycin or sorbitol . Positive_regulation MAPK15 IL1B 17559635 1753257 also *activated* extracellular signal regulated kinase , p38 [MAPK] , and c-Jun N-terminal kinase . Positive_regulation MAPK15 IL1B 17645739 1793262 Interestingly , Dex attenuated *mediated* activation of p38 [MAPK] and JNK , but not of AKT . Positive_regulation MAPK15 IL1B 17694686 1782095 IL-1beta induced NO levels and thermal hyperalgesia in rats , likely via either inhibiting the mediated p38 [MAPK] *activation* and subsequent iNOS induction , or direct attenuation of the central iNOS activity , which therefore reduces the central sensitization of inflammatory pain . Positive_regulation MAPK15 IL1B 17920534 1804182 SA981 at a concentration of 100 microM partially inhibited *induced* phosphorylation of [p38MAPK] and Akt ( 12.0 % and 36.1 % inhibition of each total amount of phosphoprotein under IL-1beta coexistence condition , respectively ) . Positive_regulation MAPK15 IL1B 17925024 1835149 *stimulated* phosphorylation of c-jun amino-terminal kinase , p38 [MAPK] and extracellular signal regulated kinase-1/2 . Positive_regulation MAPK15 IL1B 18026701 1827816 Moreover , glucosamine suppressed the *induced* phosphorylation of p38 [MAPK] ( p < 0.05 at > 0.1 mM ) and the IL-1beta binding to its receptors ( p < 0.05 at 1 mM ) . Positive_regulation MAPK15 IL1B 18065201 1853644 *stimulated* activation of ERK1/2 and p38alpha [MAPK] mediates the transcriptional up-regulation of IL-6 , IL-8 and GRO-alpha in HeLa cells . Positive_regulation MAPK15 IL1B 18348730 1925297 The *activation* or inhibition of p38 [MAPK] by and/or SB203580 was analyzed by western blotting . Positive_regulation MAPK15 IL1B 18348730 1925323 *activated* the phosphorylation of p38 [MAPK] and this effect was abolished by SB203580 . Positive_regulation MAPK15 IL1B 18427719 1920718 Phosphorylated p38 ( Phos-p38 ) [mitogen activated protein kinase] was *stimulated* in SW-1353 cells by but not by HA alone . Positive_regulation MAPK15 IL1B 18556347 1965918 or leptin individually *induced* threonine/tyrosine phosphorylation of p38 [MAPK] , whereas only leptin induced tyrosine phosphorylation of JAK2 , suggesting that leptin may enhance hBD-2 production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with NF-kappaB , which is activated by IL-1beta . Positive_regulation MAPK15 IL1B 18667841 1948046 Furthermore , induced p38 [mitogen activated protein kinase (MAPK)] *activation* and upregulation of VEGF-C mRNA and protein in LLC cells was also suppressed by artemisinin or by the p38 MAPK inhibitor SB-203580 , suggesting that p38 MAPK could serve as a mediator of proinflammatory cytokine induced VEGF-C expression . Positive_regulation MAPK15 IL1B 19362079 2081441 *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 [mitogen activated protein (MAP) kinase] , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation MAPK15 IL1B 19522843 2136334 In chondrocytes , CS diminishes *induced* increases in p38 [mitogen activated protein kinase] ( p38MAPK ) and signal regulated kinase 1/2 ( Erk1/2 ) phosphorylation , and decreases nuclear factor-kappaB (NF-kappaB) nuclear translocation and as a consequence , reduces the formation of pro-inflammatory cytokines , IL-1beta and TNF-alpha , and pro-inflammatory enzymes , such as phospholipase A2 (PLA2) , cyclooxygenase 2 (COX-2) and nitric oxide synthase-2 (NOS-2) . Positive_regulation MAPK15 IL1B 19765281 2163517 Treatment with PIP-18 blocked *induced* p38 [MAPK] phosphorylation and resulted in attenuation of sPLA2-IIA and MMP mRNA transcription in RA SF cells . Positive_regulation MAPK15 IL1B 20060906 2218516 In the present study , we demonstrate that *caused* activation of p38 [mitogen activated protein kinase] and that the p38 inhibitor SB203580 significantly blocked the effect of IL-1beta on I ( NMDA-OUT ) in hippocampal CA1 neurons . Positive_regulation MAPK15 IL1B 20353947 2266427 In model 1 , a differentiation model , CLA *activation* of [MAPK] and induction of interleukin-8 (IL-8) , IL-6 , , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation MAPK15 IL1B 21659536 2455176 Distinct roles for Nod2 protein and autocrine in muramyl dipeptide *induced* [mitogen activated protein kinase] activation and cytokine secretion in human macrophages . Positive_regulation MAPK15 IL1B 24692548 2935240 At 1 h , this was responsible for the dexamethasone inhibition of *induced* [MAPK] activation and CXCL1 and CXCL2 mRNA expression , with a similar trend for CSF2 . Positive_regulation MAPK15 IL1B 9475519 486786 Of these , *activated* only [MAPK] . Positive_regulation MAPK15 IL1B 9475519 486799 In cultured rat astrocytes , *caused* activation of [MAPK] without inducing proliferation . Positive_regulation MAPK15 IL1B 9575890 502717 Our data also indicate that both insulin and IGF-I enhance *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation and SAPK activation . Positive_regulation MAPK15 IL1B 9582321 503931 Previously we reported that *induces* activation of JNK/SAPK and p38 [MAPK] with concomitant up-regulation of cyclooxygenase (Cox)-2 expression and prostaglandin E2 ( PGE2 ) synthesis . Positive_regulation MAPK15 IL1B 9614146 509324 By Western blotting with phosphospecific antibodies and by immunocomplex kinase assay , was shown to *activate* extracellular signal regulated kinase ( ERK ) 1/2 and p38 [mitogen activated protein kinase] ( p38 ) in islets and rat insulinoma cells . Positive_regulation MAPK15 IL1B 9786861 540909 We reported previously that rapidly *activates* the c-Jun NH2-terminal/stress activated protein kinases ( JNK/SAPK ) and p38 [mitogen activated protein kinase (MAPK)] and also induces Cox-2 expression and prostaglandin E2 ( PGE2 ) production . Positive_regulation MAPK15 IL1B 9786861 540954 Overexpression of the kinase-dead form of MKK3 or MKK6 demonstrated that either of these two mutant kinases inhibited *induced* p38 [MAPK] phosphorylation and Cox-2 expression but not JNK/SAPK phosphorylation and activation . Positive_regulation MAPK15 ITGB2 12600815 1098996 IL-3 , IL-5 , and GM-CSF could enhance p38 [MAPK] and NF-kappaB activity and *induce* ICAM-1 , CD11b , and expressions on eosinophils . Positive_regulation MAPK15 ITGB2 19843511 2203196 Furthermore , beta2 integrins modulated the capacity of isolated peritoneal macrophages to take up acetylated LDL and native LDL and to phagocytose apoptotic cells , possibly via *dependent* [mitogen activated protein kinase] signalling . Positive_regulation MAPK15 LBP 20615568 2309916 Despite activating NFkappaB , NOD1 ligand did not upregulate hepatocyte production of the acute phase proteins lipopolysaccharide binding protein , serum amyloid A , or soluble CD14 in cell culture supernatants , or upregulate mRNA expression of , serum amyloid A , C-reactive protein , or serum amyloid P . NOD2 ligand ( MDP ) did not *activate* hepatocytes when given alone , but did synergize with Toll-like receptor ligands , lipopolysaccharide (LPS) , and polyI : C to activate NFkappaB and [MAPK] . Positive_regulation MAPK15 MAP2K6 10050043 592814 In one set of experiments , we *inhibited* the activation of [MAPK] by pretreating cells with PD098059 , a specific inhibitor of ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAPK15 MAP2K6 10079106 595467 Although MKK3 , MKK4 , and all *activated* p38 [MAPk] in experimental models , only MKK3 was found to activate recombinant p38 MAPk in LPS treated neutrophils . Positive_regulation MAPK15 MAP2K6 10471331 641580 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Positive_regulation MAPK15 MAP2K6 10601295 574379 In addition , *activation* of p38 [MAPK] by constitutively active or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAPK15 MAP2K6 10713051 674348 Conversely , the inhibitors PD98059 and UO126 could *attenuate* EGF induced [mitogen activated protein kinase] activation , they do not affect the EGF induced mobility shift of caveolin-1 . Positive_regulation MAPK15 MAP2K6 10759527 683124 These results demonstrate that a plant can phosphorylate and *activate* [MAPK] , and that Tyr phosphorylation is critical for the catalytic activity of MAPK in plants . Positive_regulation MAPK15 MAP2K6 10816593 714742 The MAPK kinase selectively *stimulates* p38 [MAPK] and confers protection against stress induced apoptosis in cardiac myocytes . Positive_regulation MAPK15 MAP2K6 10891559 711168 MAP kinases (MAPK) in both G-1 and G-5 cells were indistinguishably phosphorylated , yet dependent [MAPK] *activation* was observed only in G-5 cells . Positive_regulation MAPK15 MAP2K6 11005808 752388 A inhibitor , PD98059 , *inhibited* heat shock ERK [MAPK] activation by > 75 % . Positive_regulation MAPK15 MAP2K6 11085935 750682 Similarly , *activation* of JNK by Ad-MKK7D and [p38-MAPK] by resulted in the increased expression of PGHS-2 . Positive_regulation MAPK15 MAP2K6 11237743 790280 The MAPK kinase ( ) inhibitor , PD98059 , *blocked* GSA stimulated [MAPK] activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Positive_regulation MAPK15 MAP2K6 11287416 819822 The results suggest that 1 ) MAPK kinase ( ) inhibitors do not *suppress* [ERK7] kinase activity ; Positive_regulation MAPK15 MAP2K6 11304531 826818 The *activation* of p38 [MAPK] by Galpha ( q ) and Gbetagamma was blocked by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Positive_regulation MAPK15 MAP2K6 11787422 891902 Indeed the MAPK kinase ( = ) inhibitor PD98059 *inhibits* the activation of parasite [MAPK] , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Positive_regulation MAPK15 MAP2K6 11822870 908939 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of [MAPK] pathway *inhibitors* ( inhibitors PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAPK15 MAP2K6 12009309 940788 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Positive_regulation MAPK15 MAP2K6 12203369 983194 Furthermore , PKC inhibitors or an inhibitor completely *suppressed* both TPA induced activation of [MAPK] and promotion of anchorage independent growth , but a cPKC-selective inhibitor partially suppressed TPA induced promotion of the growth . Positive_regulation MAPK15 MAP2K6 12356282 993816 IL-1beta induced p44/42 [mitogen activated protein kinase (MAPK)] activation was *inhibited* by the MAPK/extracellular signal regulated protein kinase ( ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK15 MAP2K6 12377770 1019978 These results suggest that MKK3 , rather than , *mediates* alphav integrin induced p38 [MAPK] activation . Positive_regulation MAPK15 MAP2K6 12450322 1018605 ANG II significantly increased aldosterone release , and this effect was inhibited by the LO inhibitor baicalein , as well as a specific p38 [MAPK] *inhibitor* , SB202190 , but not by PD098059 , a specific inhibitor of the ERK activator . Positive_regulation MAPK15 MAP2K6 12637559 1085436 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Positive_regulation MAPK15 MAP2K6 12659851 1073372 MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a ( MAP2K ) , which in turn *activates* a [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK15 MAP2K6 12845643 1108564 Finally , both ODQ and UO126 blocked the capacity of L-arginine to restore ERK ( 1/2 ) phosphorylation in L-NAME treated cells , demonstrating that GC and are both *required* for endogenous NO-mediated [MAPK] activation . Positive_regulation MAPK15 MAP2K6 15104236 1240157 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( ) inhibitor , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAPK15 MAP2K6 15172888 1288352 Importantly , the presence of inhibitors only at the time of the transport assay markedly *impaired* both insulin stimulated glucose uptake and [MAPK] signaling . Positive_regulation MAPK15 MAP2K6 15172888 1288455 Conversely , removal of inhibitors before the transport assay *restored* glucose uptake and [MAPK] signaling . Positive_regulation MAPK15 MAP2K6 15304546 1322377 Furthermore , *activation* of [ERK/MAPK] by the coexpression of constitutively active predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAPK15 MAP2K6 15365248 1294435 Treatment of keratinocytes with PD98059 , inhibitor , and SB20358 , p38 [MAPK] *inhibitor* , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAPK15 MAP2K6 15570612 1355536 Although the inhibitors *suppressed* [MAPK] phosphorylation in both OA- and AICAR treated oocytes , meiotic resumption was not causally linked to MAPK phosphorylation in either group . Positive_regulation MAPK15 MAP2K6 15867183 1404209 In cultured cardiac myocytes , specific *activation* of stress activated [mitogen activated protein kinase] , p38 , by upstream activator led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAPK15 MAP2K6 15879307 1411349 Conversely , constitutively active *induced* p38 [MAPK] activation that recapitulated the effects of polyphenols by inducing ERalpha phosphorylation and downstream activation of Akt , and eNOS . Positive_regulation MAPK15 MAP2K6 16157033 1455613 SB203580 , a [P38MAPK] *inhibitor* , and U0126 , a inhibitor , both completely blocked ADM mediated responses in MsC . Positive_regulation MAPK15 MAP2K6 17416211 1777845 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK15 MAP2K6 18401006 1925745 CyaA enhanced LPS induced phosphorylation of p38 [MAPK] and ERK in DC , and inhibitors of p38 MAPK , , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation MAPK15 MAP2K6 18754769 1968401 ( MKK) 3 and 6 are the main p38 [mitogen activated protein kinase] *activators* in mammals . Positive_regulation MAPK15 MAP2K6 18771907 1962554 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a inhibitor , and SB203580 , an *inhibitor* of p38 [mitogen activated protein (MAP) kinase] , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAPK15 MAP2K6 21892182 2491645 Further , we show that *activation* of p38 [MAPK] by expression of constitutively active ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAPK15 MAP2K6 22164285 2517893 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of and marked *activation* of p38 [MAPK] . Positive_regulation MAPK15 MAP2K6 22785235 2691761 TRH induced CRE promoter was inhibited by [mitogen activated protein kinase/ERK] kinase ( MEK ) inhibitor and was *increased* by overexpression of . Positive_regulation MAPK15 MAP2K6 7644477 318637 Inhibition of by PD 098059 *prevented* activation of [MAPK] and subsequent phosphorylation of MAPK substrates both in vitro and in intact cells . Positive_regulation MAPK15 MAP2K6 7822248 285570 ( MKK ) phosphorylates and *activates* [mitogen activated protein kinase (MAPK)] in response to stimulation of various eukaryotic signaling pathways . Positive_regulation MAPK15 MAP2K6 7889302 289323 2. Both nucleotides stimulate phosphorylation and *activation* of [mitogen activated protein kinase] and a biphasic phosphorylation of the up-stream . Positive_regulation MAPK15 MAP2K6 8180183 256214 This stimulation of the activator was temporally *followed* by increased activities of MEK and [MAPK] . Positive_regulation MAPK15 MAP2K6 8226933 235287 *Activation* of extracellular signal regulated kinase ( ERK ) or [mitogen activated protein kinase] by ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAPK15 MAP2K6 8394352 228215 We show that a similar activity phosphorylates and *activates* [MAPK] in both growth factor stimulated ( epidermal growth factor and thrombin ) and oncogene ( gip2 , v-src , and v-raf ) -transfected cells . Positive_regulation MAPK15 MAP2K6 8550616 346638 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Positive_regulation MAPK15 MAP2K6 8663100 368132 The [MAPK] and NHE activities induced by PMA were *inhibited* by staurosporine , a potent inhibitor for protein kinase C ( PKC ) , and by MAPK kinase ( ) inhibitor , PD98059 , but were not affected by the tyrosine kinase inhibitor genistein . Positive_regulation MAPK15 MAP2K6 8663100 368223 In contrast , both AVP induced [MAPK] and NHE activities were *inhibited* by genistein and inhibitor but were not affected by staurosporine . Positive_regulation MAPK15 MAP2K6 8816498 384269 *activates* [mitogen activated protein kinase (MAPK)] , which phosphorylates other kinases as well as transcription factors . Positive_regulation MAPK15 MAP2K6 9135064 427586 In addition to dependent [MAPK] *activation* , we provide evidence for MEK independent regulation of the MAPKs . Positive_regulation MAPK15 MAP2K6 9166761 432434 The first step in [MAPK] *activation* by must be the formation of a MEK x MAPK enzyme-substrate complex , followed by phosphorylation producing monophosphorylated MAPK ( pMAPK ) . Positive_regulation MAPK15 MAP2K6 9626658 511856 These results indicate that *mediates* the IGF-I/insulin induced p42/ p44 [MAPK] activation . Positive_regulation MAPK15 MAP2K6 9864179 582696 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of ERK , but not p38 [MAPK] , induced by G-CSF , GM-CSF , or TNF . Positive_regulation MAPK15 MMP7 16848631 1588298 and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 [mitogen activated protein kinase] activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MAPK15 MMP7 21999204 2547379 Mesothelin enhances invasion of ovarian cancer by *inducing* through [MAPK/ERK] and JNK pathways . Positive_regulation MAPK15 MUC16 11481474 843776 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a [mitogen activated protein kinase] ( Erk 1/2 ) , and *activation* of transcription . Positive_regulation MAPK15 PECAM1 18029285 1866917 In contrast , expression of Delta15 in PECAM-1-/- bEND cells *had* minimal effects on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Positive_regulation MAPK15 PGC 22105890 2599537 Our studies also revealed that overexpression of in cardiomyocytes *inhibited* basal and T3-induced p38 [MAPK] phosphorylation . Positive_regulation MAPK15 PIGR 20450283 2257143 Induction of expression in HT-29 cells *required* NF-kappaB signaling but not [MAPK] signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation MAPK15 PLAT 19436314 2107034 cerebrospinal fluid and brain parenchymal ERK [MAPK] was elevated by H/I and this upregulation was *potentiated* by , but blunted by RBC-tPA . Positive_regulation MAPK15 PLAT 21037505 2499489 Red blood blocked c-Jun-N-terminal kinase but *potentiated* p38 [mitogen activated protein kinase] upregulation after photothrombotic injury . Positive_regulation MAPK15 PLAU 10766865 684599 surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha [mitogen activated protein kinase] activity . Positive_regulation MAPK15 PLAU 15031204 1257164 In HeLa cells the dominant negative form of JNK interferes with the p42/p44 [MAPK] *activation* of the . Positive_regulation MAPK15 PLAU 15874933 1405686 Activation of the [mitogen activated protein kinases (MAPK)] , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Positive_regulation MAPK15 PLAU 15874933 1405726 Although *induced* phosphorylation of both ERK1/2 and p38 [MAPK] was blocked by Galphai inhibition , inhibition of PI3K and Ras decreased the uPA induced phosphorylation of ERK1/2 but not p38 MAPK . Positive_regulation MAPK15 PLAU 18656457 1960558 Exogenous administered at 4 h post H/I further *stimulated* ERK [MAPK] phosphorylation , which was blocked by RAP . Positive_regulation MAPK15 PLAU 9660790 517494 The receptor *mediates* tyrosine phosphorylation of focal adhesion proteins and activation of [mitogen activated protein kinase] in cultured endothelial cells . Positive_regulation MAPK15 PLAU 9660790 517507 The *induced* activation of [MAPK] was completely inhibited by genistein , but not by 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo [ 3 , 4-d ] pyrimidine , a specific inhibitor of Src family kinases . Positive_regulation MAPK15 PODXL 17616675 1769268 expression also *led* to an increase in [mitogen activated protein kinase (MAPK)] and phosphatidylinositol 3-kinase (PI3K) activity . Positive_regulation MAPK15 PODXL 17616675 1769315 These findings suggest that leads to increased in vitro migration and invasion , increased MMP expression , and *increased* activation of [MAPK] and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MAPK15 PTGER2 19233324 2072054 Further , PGE ( 2 ) , EP2A and EP4A did not increase BMP2/4 mRNA levels in RC cells , and *induced* phosphorylation of p38 [MAPK] was not eliminated by Noggin . Positive_regulation MAPK15 SLC38A3 15331357 1287992 In contrast , *stimulated* [MAPK] activation was blocked by > 80 % by dominant negative Ras but not by dominant negative Rho and Cdc42 . Positive_regulation MAPK15 SNCAIP 12639553 1068698 In addition , [MAPK] was *activated* by through Edg-1 , Sph-1-P receptor . Positive_regulation MAPK15 SPHK1 18602364 1941494 As a result , inhibition of by SKI *blocked* phosphorylation of p38 [MAPK] , showing that SPHK activation by IL-18 is an upstream signal of p38 MAPK activation . Positive_regulation MAPK15 STK39 17237610 1690196 The phosphorylation of cytoplasmic p38 [MAPK] in Akata cells was *reduced* by the inhibitor , 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperazine ( H7 ) . Positive_regulation MAPK15 TLR7 16424221 1515515 MKP-1-deficient macrophages also show enhanced constitutive and induced *activation* of p38 [MAPK] . Positive_regulation MAPK15 TLR7 23979601 2850565 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Positive_regulation MAPK15 TLR7 24879442 2940946 GIT2 terminates *induced* NF-?B and [MAPK] signaling by recruiting the deubiquitinating enzyme Cylindromatosis to inhibit the ubiquitination of TRAF6 . Positive_regulation MAPK15 TNF 10504489 648976 Pretreatment with SB203580 ( 10 microM ) had no effect on basal or TNF-alpha stimulated phosphorylation of p38 MAPK but completely abolished *stimulated* p38 [MAPK] activity . Positive_regulation MAPK15 TNF 10521481 653106 The study presented here shows that autoregulation of gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 [mitogen activated protein (MAP) kinase] activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation MAPK15 TNF 10570180 568155 Furthermore , LPS , UV irradiation , and *caused* activation of p38 [MAPK] whereas IFN-gamma did not . Positive_regulation MAPK15 TNF 10601128 574183 alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation MAPK15 TNF 10640438 577493 IL-1 beta and also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK15 TNF 10669634 665802 In this study , we show that *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation MAPK15 TNF 10753884 682337 Moreover , *stimulated* both the NF-kappaB and [mitogen activated protein (MAP) kinase] ( extracellular signal regulated kinase , c-Jun NH ( 2 ) -terminal kinase , and p38 MAP kinase ) signaling pathways in astrocytes . Positive_regulation MAPK15 TNF 10783388 707843 *dependent* p38 [MAPK] activation was detected in both Mo7e and Hut-78 cells and was blocked by the p38 MAPK inhibitor , SB203580 . Positive_regulation MAPK15 TNF 10783388 707896 SB203580 did not affect TNF-alpha signaled nuclear translocation and DNA binding activity of NF-kappaB , and inhibition of NF-kappaB function did not affect *induced* p38 [MAPK] activation , indicating that these events are not dependent on each other . Positive_regulation MAPK15 TNF 10864897 705715 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK15 TNF 10864897 705767 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by and IL-1beta . Positive_regulation MAPK15 TNF 11095634 755294 rapidly *activated* [MAPK] and increased the extent of attachment , spreading and migration on fibronectin and collagen type I ( P < 0.01 ) but not on collagen type IV . Positive_regulation MAPK15 TNF 11108246 756722 *activates* extracellular regulated kinase-1/2 ( ERK1/2 ) and [p38MAPK] . Positive_regulation MAPK15 TNF 11108836 757034 In RAW264 cells which differentiate into osteoclast-like multinucleated cells by TNF treatment alone , activation of p38 [mitogen activated protein (MAP) kinase] *induced* by murine was comparable to and independent of the receptor activator of necrosis factor-kappaB ligand . Positive_regulation MAPK15 TNF 11156586 780610 1. We have previously shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce interleukin-8 (IL-8) by human pulmonary vascular endothelial cells . Positive_regulation MAPK15 TNF 11167962 783061 It has previously been shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce cytokine , including RANTES , that N-acetylcysteine (NAC) attenuates cytokine production by human bronchial epithelial cells ( BECs ) , and that sensitivity to TNFalpha is inversely correlated with cellular redox state . Positive_regulation MAPK15 TNF 11266661 797164 However , *caused* no activation of p42/p44 [MAPK] or cytosolic phospholipase A(2) activity . Positive_regulation MAPK15 TNF 11277995 798106 *activates* extracellular regulated kinases ( ERKs ) and p38 [mitogen activated protein kinase] ( p38MAPK ) , and inhibits the expression of uncoupling protein-1 (UCP-1) and adipocyte-specific genes in rat fetal brown adipocytes . Positive_regulation MAPK15 TNF 11319753 806832 SB 203580 , a selective inhibitor of p38 MAPK , inhibited IL-1 and *induced* p38 [MAPK] activity and IL-6 production ( IC ( 50 ) s 0.3 -- 0.5 microM ) in osteoblasts and chondrocytes . Positive_regulation MAPK15 TNF 11319753 806847 In addition , IL-1 and also *activated* p38 [MAPK] in fetal rat long bones and p38 MAPK inhibitors inhibited IL-1- and TNF stimulated bone resorption in vitro in a dose dependent manner ( IC ( 50 ) s 0.3 -- 1 microM ) . Positive_regulation MAPK15 TNF 11435466 832523 However , the cytotoxic responses to daunorubicin and exogenous ceramide remain unaltered , as do the induced p42/p44 [MAPK] *activation* and CD54 expression . Positive_regulation MAPK15 TNF 11438547 843389 *activated* p38 [MAPK] and p44/p42 MAPK in wild-type but not in p60 ( -/- ) , p80 ( -/- ) , or p60 ( -/- ) p80 ( -/- ) macrophages . Positive_regulation MAPK15 TNF 11494147 846168 In this study we demonstrate that *triggers* only modest proliferation , as well as p44/p42 [mitogen activated protein kinase (MAPK)] and NF-kappaB activation , in MM.1S multiple myeloma ( MM ) cells . Positive_regulation MAPK15 TNF 11495721 846382 Furthermore , overexpression of dominant negative mutants , H-Ras-15A and Raf-N4 , significantly suppressed p42/p44 [mitogen activated protein kinase (MAPK)] activation *induced* by and PDGF-BB and attenuated the effect of TNF-alpha on BK-induced IP response , indicating that Ras and Raf may be required for activation of these kinases . Positive_regulation MAPK15 TNF 11509550 848345 Although IL-1 beta and each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK15 TNF 11592111 869651 Lipopolysaccharide (LPS) treatment of a microglial cell line ( N9 ) *induced* a time dependent activation of both p38 mitogen activated protein kinase ( p38 [MAPK] ) and nuclear factor-kappaB (NFkappaB) , with consequent increases in interleukin-1alpha (IL-1alpha) , , and nitric oxide ( NO ) production . Positive_regulation MAPK15 TNF 11694522 896409 *activated* the three mammalian [MAPK] , p44/42 , JNK , and p38 , in a distinct time- and concentration dependent manner . Positive_regulation MAPK15 TNF 11694522 896435 In conclusion , although *activates* all three known [MAPK] in human preadipocytes , only p44/42 and JNK appear to be involved in the regulation of lipolysis . Positive_regulation MAPK15 TNF 11750919 898166 Biochemical and immunocytochemical analysis showed that *activated* p38 [mitogen activated protein kinase] ( p38MAPK ) and c-Jun N-terminal kinase (JNK) but not p42/p44 MAPK . Positive_regulation MAPK15 TNF 11820362 908733 *activated* p38 [MAPK] and stimulated IL-6 secretion by MG-63 cells , and pre-incubation of cells with the p38 MAPK inhibitor abrogated TNF-alpha dependent IL-6 secretion . Positive_regulation MAPK15 TNF 11820362 908747 Transfection of IL-6 full-length and 5-deletion gene promoter reporter constructs indicated that p38 [MAPK] *activation* by enhanced IL-6 gene expression , and that the p38 MAPK-responsive region resided in the proximal 260-bp segment . Positive_regulation MAPK15 TNF 11820362 908783 In conclusion , although p38 [MAPK] *activation* by stimulates IL-6 secretion by MG-63 cells , it has opposing effects on c/EBPbeta and NFkappaB activity . Positive_regulation MAPK15 TNF 11930247 927414 The p44/42 [MAPK] activity was significantly *enhanced* by and the TNF-alpha effect was opposed by rhIL-10 . Positive_regulation MAPK15 TNF 11930247 927427 It is suggested that rhIL-10 can inhibit *induced* VSMC proliferation and phosphorylation of p44/42 [MAPK] . Positive_regulation MAPK15 TNF 12095140 960559 significantly increased permeability and *induced* p38 and ERK [MAPK] activation compared with controls ( P < 0.05 ) . Positive_regulation MAPK15 TNF 12114204 963990 *increased* the phosphorylation of p38 MAPK within 15 min. Anisomycin , an activator of p38 MAPK , increased p38 [MAPK] phosphorylation and decreased SP-A mRNA levels in a dose dependent manner . Positive_regulation MAPK15 TNF 12130576 966570 Phosphorylation of p38 [MAPK] was *induced* by RANKL , IL-1 , , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation MAPK15 TNF 12131776 966848 IL-1 beta and *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK15 TNF 12297009 991033 In this study , we examined the anti-apoptotic role of p38 [MAPK] that is *activated* by in neuronal PC12 cells . Positive_regulation MAPK15 TNF 12297009 991046 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Positive_regulation MAPK15 TNF 12393915 1025411 This model probiotic also inhibits *activation* of the pro-apoptotic [p38/mitogen activated protein kinase] by , interleukin-1alpha , or gamma-interferon . Positive_regulation MAPK15 TNF 12511413 1079019 The treatment of RAW264 cells with TSA and NaB inhibited *induced* nuclear translocation of NF-kappa B and sRANKL induced activation of p38 [mitogen activated protein kinase (MAPK)] signals . Positive_regulation MAPK15 TNF 12631113 1067610 Additional experiments examining the role of cAMP on MC fractalkine expression showed that the incubation of MCs with TNF-alpha and either db-cAMP or forskolin attenuated TNF-alpha stimulated fractalkine mRNA and protein expression , preceded by attenuation of *activated* phosphorylation of p42/44 [MAPK] , and c-Jun , but not phosphorylation of PKCzeta/iota or nuclear translocation of NF-kappaB . Positive_regulation MAPK15 TNF 12637577 1099262 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and *requires* p38 [MAPK] activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation MAPK15 TNF 12665666 1030366 This study was undertaken to examine the relationship between *induced* cardiomyocyte apoptosis and activation of p38 [mitogen activated protein kinase (MAPK)] through oxidative stress . Positive_regulation MAPK15 TNF 12665666 1030379 Corresponding to the apoptotic effect , at 10 ng/mL *caused* rapid phosphorylation of p38 [MAPK] in wild-type cardiomyocytes . Positive_regulation MAPK15 TNF 12694807 1080905 *induced* the phosphorylation of p44/p42 [mitogen activated protein (MAP) kinase] and p38 MAP kinase . Positive_regulation MAPK15 TNF 12731668 1086840 On the other hand , GM-CSF- or *induced* phosphorylation of ERK and p38 [MAPK] was unaffected by these inhibitors at the concentrations effective for the inhibition of O2- release and adherence . Positive_regulation MAPK15 TNF 12829618 1113799 However , *induced* [p38-MAPK] phosphorylation was markedly diminished in mkk3-/- vs mkk3+/+ hearts ( percent basal , 127+/-23 versus 540+/-267 , respectively , P=0.04 ) , suggesting an MKK independent activation mechanism by ischemia . Positive_regulation MAPK15 TNF 12844496 1149724 Rho inhibition decreases induced endothelial [MAPK] *activation* and monolayer permeability . Positive_regulation MAPK15 TNF 12844496 1149737 Because GTP binding proteins have been implicated in MAPK activation , we now hypothesize that the GTP binding protein Rho is a mediator of induced [MAPK] *activation* and increased endothelial permeability . Positive_regulation MAPK15 TNF 12844496 1149751 C3 transferase attenuated *induced* [MAPK] activation and blocked TNF induced endothelial permeability . Positive_regulation MAPK15 TNF 12867430 1141956 Subsequently , mediated p38 [MAPK] *activation* induced sialidase activity and CD44-HA binding . Positive_regulation MAPK15 TNF 12867430 1142101 Taken together , our results suggest that induced p38 [MAPK] *activation* may regulate the induction of functionally active HA-binding form of CD44 by activating sialidase in LPS stimulated human monocytic cells . Positive_regulation MAPK15 TNF 12881424 1116126 Importantly , does not *induce* ROS accumulation or prolonged [MAPK] activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death Positive_regulation MAPK15 TNF 12893778 1121023 We show that MKK3 and MKK6are essential for *stimulated* p38 [MAPK] activation . Positive_regulation MAPK15 TNF 12960255 1158282 To investigate a potential interplay between *induced* activation of p38 [MAPK] and NF-kappaB , the p38 MAPK inhibitor SB203580 and a dominant negative p38 MAPK mutant were used . Positive_regulation MAPK15 TNF 14516792 1147198 [MAPK] pathway *activation* via was confirmed by marked AP-1 activation detected in EMSA . Positive_regulation MAPK15 TNF 14561851 1165099 In cultured human umbilical vein endothelial cells ( HUVECs ) , and lipopolysaccharide *increased* phosphorylation of p38 [MAPK] ( P-p38 MAPK ) and increased ICAM-1 expression . Positive_regulation MAPK15 TNF 14592823 1209459 Analyzing the individual contribution of PF-4 and its costimuli in the control of these functions at the signaling level , we demonstrate that *induced* activation of p38 [mitogen activated protein (MAP) kinase] ( but not extracellular regulated kinase [ Erk ] kinases ) acts as general and essential costimulatory signal in PF-4 dependent neutrophil exocytosis . Positive_regulation MAPK15 TNF 14632659 1170645 *activated* p38 [MAPK] in DCs only at an early time-point ( 15 min ) . Positive_regulation MAPK15 TNF 14654378 1176822 These findings suggest that the pre-ischemic *activation* of [p38-MAPK] by does not contribute to cardioprotection afforded by this agent . Positive_regulation MAPK15 TNF 15002040 1265070 Consistent with the abrogation of osteoclastogenic effect of DcR3 by TNFR-Fc , DcR3 treatment can *induce* osteoclastogenic cytokine release through ERK and p38 [MAPK] signaling pathways . Positive_regulation MAPK15 TNF 15139014 1246952 The increase in release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not [mitogen activated protein kinase (MAPK)] , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation MAPK15 TNF 15191888 1295234 Treatment of endothelial cells with SphK1 siRNA suppressed *induced* increase in MCP-1 mRNA levels , MCP-1 protein secretion , and activation of p38 [MAPK] . Positive_regulation MAPK15 TNF 15212763 1262306 Interestingly , Ad5NIK , but not , *induces* RelA S536 and p38 [mitogen activated protein kinase (MAPK)] phosphorylation in IKKgamma ( -/- ) cells . Positive_regulation MAPK15 TNF 15233873 1269385 A. semen also inhibited the expression of and the *activation* of [mitogen activated protein kinase] , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation MAPK15 TNF 15240695 1270277 TNF activates Syk protein tyrosine kinase leading to *induced* [MAPK] activation , NF-kappaB activation , and apoptosis . Positive_regulation MAPK15 TNF 15240695 1270297 TNF induced Syk activation was abolished by piceatannol ( Syk-selective inhibitor ) , which led to the suppression of *induced* activation of c- JNK , p38 [MAPK] , and p44/p42 MAPK . Positive_regulation MAPK15 TNF 15240695 1270313 Jurkat cells that did not express Syk ( JCaM1 , JCaM1/lck ) showed lack of *induced* Syk , JNK , p38 MAPK , and p44/p42 [MAPK] activation , as well as TNF induced IkappaBalpha phosphorylation , IkappaBalpha degradation , and NF-kappaB activation . Positive_regulation MAPK15 TNF 15240695 1270344 Overall , our results demonstrate that Syk activation plays an essential role in *induced* activation of JNK , p38 [MAPK] , p44/p42 MAPK , NF-kappaB , and apoptosis . Positive_regulation MAPK15 TNF 15240725 1270452 p38 [MAPK] was *activated* by and oxidants in nonadherent conditions i.e. , with 10 mM EDTA . Positive_regulation MAPK15 TNF 15240725 1270466 Finally , p38 [MAPK] *activation* by was blocked by diphenylene iodonium , an inhibitor of flavoprotein oxidoreductase , and by the free radical scavenger N-acetylcystein . Positive_regulation MAPK15 TNF 15265936 1275727 Besides NF-kappa B , celecoxib also suppressed *induced* JNK , p38 [MAPK] , and ERK activation . Positive_regulation MAPK15 TNF 15290420 1278545 Halothane or isoflurane augmented the LPS- and *induced* activation of p38 [MAPK] . Positive_regulation MAPK15 TNF 15304089 1284474 DNCB , NiSO ( 4 ) and *activated* p38 [mitogen activated protein kinases (MAPK)] and c-jun N-terminal kinase ( JNK ) . Positive_regulation MAPK15 TNF 15322069 1333416 We have also investigated the phosphorylation of p42/44 [MAPK] and *upregulation* of RhoA protein by . Positive_regulation MAPK15 TNF 15452110 1341986 In contrast , *induced* p42/p44 [MAPK] activation and CD54 expression remained unaltered . Positive_regulation MAPK15 TNF 15589482 1356206 In addition , luteolin inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , IkappaB degradation , and NF-kappaB activation . Positive_regulation MAPK15 TNF 15659876 1350282 The anabolic effect of was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an extracellular regulated kinases (ERK) . Positive_regulation MAPK15 TNF 15696169 1372150 Using TCPTP-deficient fibroblasts , we show here that TCPTP regulates *induced* [MAPK] but not NF-kappaB signaling . Positive_regulation MAPK15 TNF 15696169 1372196 These results link TCPTP and Src tyrosine kinases to the selective regulation of *induced* [MAPK] signaling and identify a previously unknown mechanism for modulating inflammatory responses mediated by TNF . Positive_regulation MAPK15 TNF 15703956 1497463 *Activation* of p38 [mitogen activated protein (MAP) kinase] and phosphatidylinositol 3-kinase (PI3K) by was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation MAPK15 TNF 15792609 1386786 By stimulation of in AM-1 cells , the phosphorylation of Akt ( Ser473 ) and p44/42 [mitogen activated protein kinase (MAPK)] ( Thr202/Tyr204 ) was markedly *increased* in TNFalpha concentration and time dependent manner . Positive_regulation MAPK15 TNF 15792609 1386802 Pretreatment with U0126 , mitogen activated extracellular regulated kinase ( MEK) 1/2 inhibitor , prior to TNFalpha stimulation , specifically inhibited *induced* phosphorylation of p44/42 [MAPK] ( Thr202/Tyr204 ) in AM-1 cells . Positive_regulation MAPK15 TNF 15792609 1386815 Meanwhile , pretreatment with LY294002 , phosphatidylinositol-3-OH kinase (PI3K) inhibitor , could inhibit both *induced* phosphorylation of Akt ( Ser473 ) and p44/42 [MAPK] ( Thr202/Tyr204 ) . Positive_regulation MAPK15 TNF 15823554 1393907 Furthermore , potently *activated* p38 [MAPK] , JNK , and NF-kappaB . Positive_regulation MAPK15 TNF 15837794 1432544 Expression of this protein inhibited *induced* activation of NFkappaB , JNK , and p38 [MAPK] and sensitized the cells to TNF induced apoptosis . Positive_regulation MAPK15 TNF 15845648 1425542 *induces* a more than tenfold increase in p38 [mitogen activated protein kinase (MAPK)] but not extracellular signal regulated kinase phosphorylation . Positive_regulation MAPK15 TNF 15870903 1405541 In addition , GA inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , I kappa B alpha degradation , and NF-kappa B activation . Positive_regulation MAPK15 TNF 16009485 1441393 Moreover , p44/42 [mitogen activated protein kinase] appears to partly *mediate* the negative effect of insulin but not on ATGL . Positive_regulation MAPK15 TNF 16023081 1441582 Ellagic acid inhibited IL-1beta- and induced *activation* of activator protein-1 and mitogen activated protein kinases ( extracellular signal regulated kinase , c-Jun N-terminal kinase and p38 [mitogen activated protein kinase] ) , but not of nuclear factor-kappaB . Positive_regulation MAPK15 TNF 16025396 1435603 *activated* the phosphorylation of p44/42 [MAPK] , p38 MAPK , SAPK/JNK and Akt in mesangial cells . Positive_regulation MAPK15 TNF 16025396 1435619 PGE1 inhibited the *induced* phosphorylation of SAPK/JNK and Akt , but not p44/42 [MAPK] and p38 MAPK . Positive_regulation MAPK15 TNF 16080915 1442762 Comparative gene array analysis of *induced* [MAPK] and NF-kappaB signaling pathways between retinal ganglion cells and glial cells . Positive_regulation MAPK15 TNF 16140562 1499245 These results suggested that TNFalpha induced both cell survival and apoptosis pathways in ameloblastoma and potential of TNFalpha in inducing apoptosis can be improved by inhibiting *induced* Akt and p44/42 [mitogen activated protein kinase (MAPK)] cell survival pathways . Positive_regulation MAPK15 TNF 16275991 1480277 Angiotensin II , , or epidermal growth factor *induced* [MAPK] phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation MAPK15 TNF 16291729 1526062 *Activation* of [MAPK] and Akt by anti-HER2/neu inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation MAPK15 TNF 16314440 1486993 treatment *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation in NPCs , and SB202190 , an inhibitor of p38 MAPK , blocked TNF-alpha induced chemokine production . Positive_regulation MAPK15 TNF 16325162 1511659 Furthermore , APE1/ref-1 overexpression inhibited the *induced* increase in intracellular superoxide and p38 [MAPK] phosphorylation . Positive_regulation MAPK15 TNF 16452991 1611726 Western blots showed that IL-1beta and *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK15 TNF 16517732 1530912 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of , but not IL-6 , *requires* the activity of p38 [MAPK] . Positive_regulation MAPK15 TNF 16573652 1556131 HA-mediated production *required* p38 [MAPK] , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation MAPK15 TNF 16682409 1584051 Further , the deletion of NQO1 abolished *induced* c-Jun N-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] activation . Positive_regulation MAPK15 TNF 16781693 1585610 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and and the *activation* of [MAPK] 's are potentially positive signals for IL-10 production . Positive_regulation MAPK15 TNF 16798728 1638529 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Positive_regulation MAPK15 TNF 16875982 1593556 *activates* [p38-MAPK] , a stress-responsive kinase implicated in contractile depression and cardiac injury . Positive_regulation MAPK15 TNF 16875982 1593570 Under conditions of constant coronary flow , the [p38-MAPK] activation and contractile depression *induced* by , though attenuated , remained sensitive to the absence of MKK3 or the presence of SB203580 . Positive_regulation MAPK15 TNF 16875982 1593584 *activates* [p38-MAPK] in the intact heart and in isolated cardiac myocytes through MKK3 . Positive_regulation MAPK15 TNF 16982923 1617357 Compared with wild-type cells , MIF-deficient cells were hyporesponsive to IL-1- and *induced* [MAPK] activity , AP-1 activity , and cellular proliferation , while NF-kappaB function was preserved . Positive_regulation MAPK15 TNF 17070777 1649822 Inhibition of Syk down-regulated *induced* p38 and p44/42 [MAPK] phosphorylation and nuclear translocation of p65 NF-kappaB . Positive_regulation MAPK15 TNF 17099067 1676195 Importantly , Dex is able to increase the expression of MKP-1 , which causes an inactivation of *induced* p38 [MAPK] and mediates inhibition of E-selectin expression . Positive_regulation MAPK15 TNF 17126899 1677667 Stimulation of ECs with *induced* rapid increases in the phosphorylation of their mitogen activated protein kinases ( MAPKs ) [ extracellular signal regulated kinase ( ERK ) , c-Jun-NH2-terminal kinase (JNK) , and p38 [MAPK] ] ; Positive_regulation MAPK15 TNF 17126905 1686537 Differential regulation of and GM-CSF *induced* activation of P38 [MAPK] in neutrophils and eosinophils . Positive_regulation MAPK15 TNF 17138860 1653541 The role of delta-PKC in *mediated* activation of [MAPK] is not known . Positive_regulation MAPK15 TNF 17138860 1653567 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 MAPK are involved in TNF antiapoptotic signaling and whether delta-PKC is a key regulator of [MAPK] *activation* by . Positive_regulation MAPK15 TNF 17138860 1653593 In human neutrophils , *activated* both p38 [MAPK] and ERK1/2 principally via TNFR-1 . Positive_regulation MAPK15 TNF 17158449 1694233 A green fluorescent protein fusion protein containing the last 100 residues of TAK1 ( TAK1-C100 ) abolished the interaction of endogenous TAB2/TAB3 with TAK1 , the phosphorylation of TAK1 , and prevented the activation of IKK and [MAPK] *induced* by IL-1 , , and RANKL . Positive_regulation MAPK15 TNF 17161959 1694533 Upon examination of the signaling components , we found that was a potent *activator* of p38 , p44/42 , p54/46 [MAPK] , and IkappaBalpha ( IkappaBalpha ) . Positive_regulation MAPK15 TNF 17172975 1679381 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the [MAPK] , and production of . Positive_regulation MAPK15 TNF 17172975 1679407 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the [MAPK] , and production of . Positive_regulation MAPK15 TNF 17189827 1680140 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Positive_regulation MAPK15 TNF 17202326 1680809 Augmented lipopolysaccharide induced production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK15 TNF 17202326 1680835 In this study , we show that augmented LPS induced production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK15 TNF 17218473 1732505 The RhoA inhibitor C3 exoenzyme and the ROCK inhibitor Y-27632 both attenuated *induced* [MAPK] activation and blocked AR expression in HIMEC . Positive_regulation MAPK15 TNF 17220297 1703048 TRAF2 and ASK1 play essential roles in *induced* [mitogen activated protein kinase] signaling . Positive_regulation MAPK15 TNF 17258890 1725386 The effects of and FasL on GrB expression were specifically *mediated* by [p38MAPK] ( Mitogen-activated-protein-kinase ) activation . Positive_regulation MAPK15 TNF 17425653 1748778 The percentage increases in IL-18 induced phosphorylation of extracellular signal regulated kinase ( ERK ) in Th cells of NDN and DN were significantly higher than controls ( P < 0.05 ) , while the percentage increase in *induced* phosphorylation of p38 [MAPK] in monocytes and IL-18 induced phosphorylation of p38 MAPK in Th cells and monocytes were significantly higher in NDN patients than controls . Positive_regulation MAPK15 TNF 17438131 1742750 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation MAPK15 TNF 17438336 1749070 FAK promoted *stimulated* [MAPK] activation needed for maximal IL-6 production . Positive_regulation MAPK15 TNF 17438336 1749085 Analysis of FAK ( -/- ) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity , Tyr-397 phosphorylation , and the Pro-712/713 proline-rich region of FAK were required for *stimulated* [MAPK] activation and IL-6 production . Positive_regulation MAPK15 TNF 17446186 1749501 *increased* p38 [MAPK] phosphorylation , potently stimulated IRS-1 serine phosphorylation , and blunted insulin stimulated IRS-1 tyrosine and Akt phosphorylation and eNOS activity . Positive_regulation MAPK15 TNF 17531219 1762165 On the other hand , aloe emodin did not affect induced *activation* of p38 [mitogen activated protein kinase] or generation of reactive oxygen species . Positive_regulation MAPK15 TNF 17607712 1798183 Although *induced* the activation of p38 [MAPK] , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation MAPK15 TNF 17725582 1801629 MAC inhibited induced p38 [mitogen activated protein kinase] *activation* and cell death in cultured Schwann cells . Positive_regulation MAPK15 TNF 17895408 1823959 IA did not interfere with induced *activation* of c-Jun N-terminal kinase (JNK) and p38 [mitogen activated protein kinase] . Positive_regulation MAPK15 TNF 17942934 1814208 Deletion of NQO2 also abolished induced c-Jun NH2-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] *activation* . Positive_regulation MAPK15 TNF 17994109 1851152 triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 [MAPK] , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation MAPK15 TNF 18039275 1828523 Further downstream in this axis of signalling , blockade *reduces* only acute bronchoconstriction , while [MAPK] inhibition abrogates completely endotoxin induced inflammation . Positive_regulation MAPK15 TNF 18060043 1853596 In cultures of Schwann cells , astrocytes , and microglia , sLRP-alpha inhibited *induced* activation of p38 [MAPK] and ERK/MAPK . Positive_regulation MAPK15 TNF 18061162 1861511 We demonstrate that *induced* proliferation of C4HD murine mammary tumor cells and of T47D cells through the activation of p42/p44 [MAPK] , JNK , PI3-K/Akt pathways and nuclear factor-kappa B (NF-kappa B) transcriptional activation . Positive_regulation MAPK15 TNF 18091748 1847359 *induced* phosphorylation of extracellular signal regulated kinase ( ERK ) and Akt , but not p38 [mitogen activated protein kinase (MAPK)] , was attenuated by nicardipine , cilnidipine , benidipine , efonidipine , and azelnidipine . Positive_regulation MAPK15 TNF 18227157 1884340 It was shown that these three proteins could ( i ) induce expression of and tissue factor and ( ii ) *induce* phosphorylation of p44/42 [mitogen activated protein kinases (MAPK)] and activation of early growth response factor 1 (Egr-1) . Positive_regulation MAPK15 TNF 18258304 1884791 However , over-expression of a dominant negative form of Rac strongly inhibited induced p42/44 [MAPK] kinase *activation* , but had little effect upon JNK and no effect upon p38 MAPK activity . Positive_regulation MAPK15 TNF 18287053 1872484 Here , we show that the murine CMV M45 protein binds to RIP1 and inhibits *induced* activation of NF-kappaB , p38 [MAPK] , and caspase independent cell death . Positive_regulation MAPK15 TNF 18287248 1896516 Flavopiridol suppresses *induced* activation of activator protein-1 , c-Jun N-terminal kinase , p38 [mitogen activated protein kinase (MAPK)] , p44/p42 MAPK , and Akt , inhibits expression of antiapoptotic gene products , and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells . Positive_regulation MAPK15 TNF 18314542 1931901 P < 0.05 ) , and MKP-1 up-regulation was temporally related to the inhibition of *induced* p38 [MAPK] phosphorylation . Positive_regulation MAPK15 TNF 18336852 1912235 *stimulated* phosphorylation of p42/p44 [MAPK] and JNK were attenuated by pretreatment with the inhibitors U0126 and SP600125 or transfection with dominant negative mutants of DeltaERK and DeltaJNK . Positive_regulation MAPK15 TNF 18364436 1912762 We , for the first time , demonstrate that binding of staphylococcal enterotoxin B to MHC-II results in activation of TNF-alpha converting enzyme , epidermal growth factor receptor , [p38MAPK] , and NF-kappaB *inducing* biphasic production . Positive_regulation MAPK15 TNF 18443205 1938520 Conversely , *induced* increases in insulin receptor substrate-1 serine phosphorylation ( Ser ( 312 ) ) , Jun NH ( 2 ) -terminal kinase phosphorylation , and extracellular signal related kinase-1/2 [mitogen activated protein kinase (MAPK)] phosphorylation were unaltered by siRNA mediated IKKbeta reduction . Positive_regulation MAPK15 TNF 18518937 1971915 Although Cot/Tpl2 was phosphorylated in IRI and in the cultured tubular epithelial cells (TEC) after stimulation with LPS and hydrogen peroxide , there were no significant differences in terms of production , neutrophil infiltration or [MAPK] *activation* between Cot/Tpl2 ( +/+ ) and Cot/Tpl2 ( -/- ) mice . Positive_regulation MAPK15 TNF 18636175 1937264 Furthermore , glucosamine inhibited the *induced* phosphorylation of [p38MAPK] and NF-kappaB p65 , and the nuclear translocation of NF-kappaB in the cells . Positive_regulation MAPK15 TNF 18653803 1960511 PMA stimulated nSMase2 translocation was independent of p38 MAPK , and neither PKC inhibitors nor small interfering RNA had significant effects on *stimulated* p38 [MAPK] activation , indicating that PKC-delta does not act through p38 MAPK in regulating nSMase2 . Positive_regulation MAPK15 TNF 18710428 2028196 As for the signalling pathway , stimulation *led* to the phosphorylation of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and translocation of nuclear factor kappaB (NF-kappaB) ( p65 ) into the nuclei . Positive_regulation MAPK15 TNF 18710428 2028211 These data suggest that interaction *leads* to the phosphorylation of Erk1/2 and [p38MAPK] and nuclear translocation of NF-kappaB , which is closely associated with the production and activation of MMP-9 in cultured CC cells of HuCTT-1 and CCKS-1 . Positive_regulation MAPK15 TNF 18768892 1957203 Consistently , Nod2-null macrophages tolerant to LPS and MDP showed enhanced production of and IL-6 as well as increased NF-kappaB and [MAPK] *activation* in response to the dipeptide KF1B , the Nod1 agonist . Positive_regulation MAPK15 TNF 18948845 2053234 Hypertonic saline did not alter *induced* p38 [mitogen activated protein kinase] phosphorylation or constitutive vascular endothelial growth factor expression , suggesting that the observed inhibition is not a generalized suppression of protein phosphorylation or cellular function . Positive_regulation MAPK15 TNF 19100731 2031216 at 30 ng/ml significantly *increased* phosphorylation of receptor tyrosine kinase ( 175 kDa ) and p42 [mitogen activated protein (MAP) kinase] . Positive_regulation MAPK15 TNF 19130554 2025295 Stimulation of HIMEC with *triggered* phosphorylation of the [MAPK] , and up-regulation of VCAM-1 , FKN and ICAM-1 . Positive_regulation MAPK15 TNF 19234337 2079504 Analysis of downstream signals showed that inhibition of NAD(P)H oxidase partially inhibited NF-kappaB activation but did not reduce CCL2 mRNA stability or prevent *induced* phosphorylation of [p38MAPK] . Positive_regulation MAPK15 TNF 19275968 2072836 *stimulated* the phosphorylation levels of p38 [MAPK] , JNK , ERK1/2 and Akt in vascular endothelial cells . Positive_regulation MAPK15 TNF 19289468 2073033 The requirement for MADD was highly specific for *induced* activation of [MAPK] but not the related JNK and p38 kinases . Positive_regulation MAPK15 TNF 19371952 2081744 Of note , the IFN-gamma plus *stimulated* activation of p38 [MAPK] was suppressed following incubation with forskolin or DBcAMP alone . Positive_regulation MAPK15 TNF 19410630 2089689 By transfection of TAK1 siRNA , *induced* phosphorylation of IkappaBalpha , JNK1/2 , and [p38MAPK] , as well as IL-6 or IL-8 expression , were repressed . Positive_regulation MAPK15 TNF 19427347 2106789 *induced* the phosphorylation of p38 [mitogen activated protein (MAP) kinase] , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation MAPK15 TNF 19429670 2106849 Ang II and clearly *enhanced* ERK and [p38MAPK] phosphorylation . Positive_regulation MAPK15 TNF 19563733 2122002 Finally , EZS inhibited *induced* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phosphorylation . Positive_regulation MAPK15 TNF 19648110 2138326 This correlates with reduced *stimulated* p38 [MAPK] phosphorylation . Positive_regulation MAPK15 TNF 19648110 2138339 Repression of *induced* p38 [MAPK] phosphorylation , NF-kappaB dependent transcription , and IL-8 expression by dexamethasone are sensitive to transcriptional or translational inhibitors . Positive_regulation MAPK15 TNF 19648110 2138409 Thus , MKP-1 attenuates *dependent* activation of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Positive_regulation MAPK15 TNF 19648110 2138439 Small interfering RNA knockdown of dexamethasone induced MKP-1 expression partially reverses the repression of *activated* p38 [MAPK] , demonstrating that MKP-1 participates in the dexamethasone dependent repression of this pathway . Positive_regulation MAPK15 TNF 19788916 2163917 Tumor necrosis factor ( ) and H ( 2 ) O ( 2 ) *activate* [mitogen activated protein kinase (MAPK)] in SH-SY5Y cells within 5 min and this activation is completely blocked by DLPC ( 12 microM ) . Positive_regulation MAPK15 TNF 19877072 2160706 CpdA also displayed profound effects on *induced* [MAPK] activation . Positive_regulation MAPK15 TNF 19877072 2160721 In sharp contrast , DEX did not affect *induced* IKK phosphorylation , IkappaBalpha degradation , p65 nuclear translocation , or [MAPK] activation in RA FLS . Positive_regulation MAPK15 TNF 19889458 2197298 Calpain inhibition induces random migration in TNF-alpha stimulated cells and prevents the generation of reactive oxygen species , but does not alter *mediated* activation of p38 MAPK and ERK [MAPK] . Positive_regulation MAPK15 TNF 20231691 2237853 TNF-alpha treatment resulted in the phosphorylation of p38 MAPK and its downstream target , MAPK activated protein kinase-2 , but IFN-gamma did not affect the levels of [MAPK] and MAPK activated protein kinase-2 phosphorylation *induced* by . Positive_regulation MAPK15 TNF 20489729 2327415 *induced* activation of p38 [MAPK] and the production of inducible nitric oxide synthase were suppressed in ASK1-deficient Müller glial cells . Positive_regulation MAPK15 TNF 20646342 2292543 Effects of budesonide on P38 [MAPK] activation , apoptosis and IL-8 secretion , *induced* by and Haemophilus influenzae in human bronchial epithelial cells . Positive_regulation MAPK15 TNF 20646342 2292572 induced a significant *increase* in p38 [MAPK] phosphorylation . Positive_regulation MAPK15 TNF 20693316 2351472 In four of the six donors , basal and *induced* ERK and p38 [MAPK] activation were higher in ASMA than ASMNA cells . Positive_regulation MAPK15 TNF 20696856 2351504 Surprisingly , replenishment with exogenous GSH normalizes both *dependent* NF-?B as well as [MAPK] signaling and rescues hepatocytes from FKB induced death . Positive_regulation MAPK15 TNF 20951126 2364941 Taken together , this study provided first evidence demonstrating that TRAIL- , , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK15 TNF 21123734 2377717 The ability of CO to inhibit *induced* ERK1/2 and p38 [MAPK] activities in an Akt dependent manner appears to be the key element in ROS dependent survival of endothelial cells during TNF-a mediated brain inflammatory disease . Positive_regulation MAPK15 TNF 21181166 2499595 IL-1ß and *activated* the intracellular mitogen activated protein kinases ( MAPKs ) : p44/42 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) as well as nuclear factor-?B ( NF-?B ) in osteoblasts . Positive_regulation MAPK15 TNF 21285293 2425708 Inhibitors of NADPH oxidase and/or p47phox siRNA diminished ROS production and COX-2 expression as well as phosphorylation of p38 [mitogen activated protein kinase] ( p38MAPK ) and Akt *mediated* either by AS serum or by . Positive_regulation MAPK15 TNF 21336587 2457984 Effects of preconditioning with sevoflurane on *induced* permeability and activation of p38 [MAPK] in rat pulmonary microvascular endothelial cells . Positive_regulation MAPK15 TNF 21422246 2416763 Interestingly , all PHA-L ( high ) DCs displayed a strongly reduced responsiveness to *induced* [p38-MAPK] activation compared with PHA-L ( low ) DCs , indicating differences in PHA-L binding capacities between DCs with different inflammatory properties . Positive_regulation MAPK15 TNF 21422246 2416777 Moreover , hybrid-type , but not complex-type , N-glycans are required for *induced* [p38-MAPK] activation and subsequent phenotypic maturation of BMDCs ( MHC-II , CD86 , CCR7 upregulation ) . Positive_regulation MAPK15 TNF 21520062 2423116 Here , we report that *induced* cPLA(2) protein and mRNA expression , PGE ( 2 ) production , and phosphorylation of p42/p44 MAPK , p38 [MAPK] , and JNK1/2 , which were attenuated by pretreatment with a ROS scavenger [ N-acetyl-L-cysteine , ( NAC ) ] and the inhibitors of NADPH oxidase [ apocynin (APO) and diphenyleneiodonium chloride ( DPI ) ] , MEK1/2 ( U0126 ) , p38 MAPK ( SB202190 ) , and JNK1/2 ( SP600125 ) or transfection with siRNA of Nox2 , p47(phox) , MEK1 , p42 , p38 , or JNK2 . Positive_regulation MAPK15 TNF 21545687 2554372 significantly *induced* phosphorylation of p38 [MAPK] , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation MAPK15 TNF 21894146 2510852 Vehicle and untreated NTN exhibited heavy proteinuria and glomerular thrombosis at 24 h with P-selectin and fibrin immunostaining within capillaries , glomerular macrophage and T cell infiltration , *activation* of JNK and p38 [MAPK] signalling , and upregulation of glomerular mRNA levels of pro-inflammatory molecules ( , NOS2 , MMP-12 and CCL2 ) . Positive_regulation MAPK15 TNF 22002864 2526322 These results suggest that H ( 2 ) O ( 2 ) -induced secretion of *increases* apoptosis of cardiac myocytes through ROS dependent activation of p38 [MAPK] . Positive_regulation MAPK15 TNF 22227193 2544571 Casuarinin significantly inhibited induced *activation* of NF-?B , STAT1 , and p38 [MAPK] . Positive_regulation MAPK15 TNF 22230399 2519471 KMUP-1 inhibited *induced* iNOS and U46619 induced PDE-5A and phospho-p38 [MAPK] in normoxia , confirming its anti-proinflammatory action . Positive_regulation MAPK15 TNF 22250084 2551206 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Positive_regulation MAPK15 TNF 22343222 2617768 Using immunohistological techniques , we showed a higher epithelial expression of , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator [protein-1/mitogen activated protein kinase] signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation MAPK15 TNF 22525504 2522567 *up-regulated* the phosphorylation levels of p38 [MAPK] and increased the translocation of NF-kB p65 protein into the nucleus , also proved by immunofluorescence staining . Positive_regulation MAPK15 TNF 22526394 2595907 also *increased* the production of inducible nitric oxide synthase (iNOS) , nitric oxide ( NO ) , and intercellular adhesion molecule 1 ( ICAM-1 ) through activation of p38 [mitogen activated protein kinase (MAPK)] from HT-29 cells . Positive_regulation MAPK15 TNF 22773691 2659897 *induced* activation of p38 [MAPK] and NF-?B was attenuated by miR-140-3p mimic . Positive_regulation MAPK15 TNF 22819264 2646090 CORM-2 inhibited *induced* activation of p38 [MAPK] , ERK1/2 , JNK , and NF-?B signaling pathways in HUVECs . Positive_regulation MAPK15 TNF 22947346 2678656 *induced* phosphorylated p38 [mitogen activated protein kinase] levels were increased in ASMCs from patients with severe asthma compared with those from patients with nonsevere asthma and nonasthmatic subjects , whereas TNF-a induced phosphorylated c-Jun N-terminal kinase and phosphorylated extracellular signal related kinase levels were increased in all asthmatic groups . Positive_regulation MAPK15 TNF 22988345 2674349 The EGF receptor and HER2 participate in *dependent* [MAPK] activation and IL-8 secretion in intestinal epithelial cells . Positive_regulation MAPK15 TNF 22988345 2674377 As the epidermal growth factor receptor (EGFR) is a known transducer of proliferative signals and a potent activator of MAPKs , we hypothesized that the EGFR participates in *dependent* [MAPK] activation and IL-8 secretion by intestinal epithelial cells ( IECs ) . Positive_regulation MAPK15 TNF 23071098 2720892 Mixed-effects modeling analysis of our data was vital for ascertaining that IL-1a and TGF-a treatment increased the activities of more pathways than IL-6 and TNF-a and that TGF-a and *increased* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phospho-protein levels in a synergistic manner . Positive_regulation MAPK15 TNF 23142559 2722781 Western blot analysis revealed that pilocarpine and physostigmine enhanced the *induced* phosphorylation of ERK1/2 and p38 [MAPK] and the degradation of I?Ba . Positive_regulation MAPK15 TNF 23333920 2758376 Interestingly , IL-27 promoted the basal and enhanced *induced* phosphorylation of p38 [MAPK] and Akt , but not I?Ba . Positive_regulation MAPK15 TNF 23353699 2754235 We further demonstrated that markedly *stimulated* p38 [MAPK] , p42/p44 MAPK , and JNK1/2 phosphorylation via a c-Src/EGFR , PDGFR/PI3K/Akt pathway . Positive_regulation MAPK15 TNF 23354775 2770069 p38a [mitogen activated protein kinases (MAPK)] may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , , interleukin-1ß , and oxidative stress . Positive_regulation MAPK15 TNF 23664593 2838378 sFGL2 secretion by CD4 ( + ) T cells can be *induced* with and IFN-? stimulation through [MAPK] signaling in renal allograft AR . Positive_regulation MAPK15 TNF 23861542 2817176 ROCK1 dependent release of myosin was necessary for the dependent recruitment of TRAF2 to p75 and for p75-specific *activation* of NF-?B and [MAPK] signaling . Positive_regulation MAPK15 TNF 23884101 2821463 Furthermore , P. vulgaris extract suppressed *induced* phosphorylation of p38 [mitogen activated protein kinase (MAPK)] and extracellular signal regulated kinase ( ERK ) . Positive_regulation MAPK15 TNF 23935096 2840755 In contrast , loss of SK1 prevented *induced* phosphorylation of p38 [MAPK] , and inhibition of p38 MAPK , like SK1 knockdown , also potentiates RANTES induction . Positive_regulation MAPK15 TNF 24069158 2846988 We showed that markedly *stimulated* p42/p44 [MAPK] , p38 MAPK , and JNK1/2 phosphorylation which were attenuated by their respective inhibitors . Positive_regulation MAPK15 TNF 24080497 2902534 Consistently , DUSP1 promotes apoptosis and decreases NF-?B activity in cells in which p38 [MAPK] is *induced* by treatment . Positive_regulation MAPK15 TNF 24089494 2848145 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed receptor 1 and *requires* activation of p38 [MAPK] , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation MAPK15 TNF 24361597 2911240 We further demonstrated that *stimulated* ERK1/2 , p38 [MAPK] , and JNK1/2 phosphorylation via a c-Src dependent PDGFR/PI3K/Akt pathway . Positive_regulation MAPK15 TNF 24378531 2911768 TRAF2 has been previously reported to be required for *induced* activation of p38 [MAPK] . Positive_regulation MAPK15 TNF 24441870 2922924 We showed that markedly *stimulated* Jak2 , PDGFR , Akt , and p42/p44 [MAPK] phosphorylation , which were attenuated by their respective inhibitors . Positive_regulation MAPK15 TNF 24441870 2922946 In addition , *induced* p42/p44 [MAPK] phosphorylation was reduced by AG1296 or LY294002 . Positive_regulation MAPK15 TNF 24441870 2922979 On the other hand , could *induce* Akt and p42/p44 [MAPK] translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation MAPK15 TNF 24446489 2912933 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Positive_regulation MAPK15 TNF 24489443 2884786 Finally , by investigating the intracellular pathways involved in promoting the VEC release of cytokines/chemokines , which are targeted by natural anti-inflammatory compounds , we documented that aLipoic acid significantly counteracted *induced* NF-?B and [p38/MAPK] activation while the effects of Ginkgo biloba appeared to be predominantly mediated by Akt . Positive_regulation MAPK15 TNF 24750790 2936524 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas and NO production *required* all three [MAPK] . Positive_regulation MAPK15 TNF 7689564 225759 *induced* activation and increased tyrosine phosphorylation of [mitogen activated protein (MAP) kinase] in human fibroblasts . Positive_regulation MAPK15 TNF 7689564 225772 *induced* activation of [MAPK] was demonstrated by its enhanced ability to phosphorylate myelin basic protein in vitro and by a characteristic shift in the electrophoretic mobility of MAPK proteins . Positive_regulation MAPK15 TNF 7722327 301752 *induces* tyrosine phosphorylation of [mitogen activated protein kinase] in adherent human neutrophils . Positive_regulation MAPK15 TNF 7722327 301778 PMN pretreatment with genistein , a tyrosine kinase inhibitor , inhibited the *induced* increase in tyrosine phosphorylation and [MAPK] activity . Positive_regulation MAPK15 TNF 8626494 360271 Inhibition of induced p42/p44 [mitogen activated protein kinase] *activation* by sodium salicylate . Positive_regulation MAPK15 TNF 8626494 360285 *activates* both p42 and p44 [mitogen activated protein kinases (MAPK)] in human FS-4 fibroblasts , cells for which TNF is mitogenic . Positive_regulation MAPK15 TNF 8626494 360298 We now show that *activates* p42 [MAPK] in two cell lines whose growth is inhibited by TNF . Positive_regulation MAPK15 TNF 8626494 360313 We now show that neither phorbol ester-sensitive protein kinase C nor Gialpha link TNF to p42/p44 MAPK activation , because pretreatment of FS-4 cells with phorbol ester to down-regulate protein kinase C or pretreatment with pertussis toxin to block Gialpha does not inhibit p42/p44 [MAPK] *activation* by . Positive_regulation MAPK15 TNF 8626494 360330 To further analyze MAPK activation in FS-4 cells , we compared p42/p44 [MAPK] *activation* by and epidermal growth factor (EGF) . Positive_regulation MAPK15 TNF 8626494 360358 Elucidation of the mechanism whereby sodium salicylate blocks *induced* p42/p44 [MAPK] activation may help to clarify TNF activated signaling pathways . Positive_regulation MAPK15 TNF 8662702 367177 additionally *caused* rapid p38 and JNK-1 [mitogen activated protein kinase] activation and efficient NF-kappaB translocation , which could not be achieved even by high levels of ceramide . Positive_regulation MAPK15 TNF 9106254 424403 The increases in [MAPK] *induced* by and IL-1 were similar to the increases induced by PMA and PDGF-AB . Positive_regulation MAPK15 TNF 9106254 424429 Our findings indicate that and IL-1 activate parallel signal transduction pathways in human neuroma fibroblasts , and that they are relatively stronger *activators* of [MAPK] than of SAPK . Positive_regulation MAPK15 TNF 9315666 456095 , an inhibitor of insulin stimulated adipogenesis , *activated* [MAPK] in 3T3-L1 cells . Positive_regulation MAPK15 TNF 9439626 482864 *increased* ERK1 and ERK2 [MAPK] phosphorylation . Positive_regulation MAPK15 TNF 9439626 482890 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic effect of *requires* protein tyrosine phosphorylation and [MAPK] activation . Positive_regulation MAPK15 TNF 9593119 505480 The CAZ released endotoxin was similar to purified LPS with respect to the following biological activities in LPS-responsive C3H/HeN mice and LPS-hyporesponsive C3H/HeJ mice : lethal toxicity in GalN sensitized mice , in vitro induction of and NO production by macrophages , and [mitogen activated protein kinase] *activation* in macrophages . Positive_regulation MAPK15 TNF 9766635 538498 Our data suggest that and GM-CSF *activate* ERKs and p38 [MAPK] by different signal transduction pathways . Positive_regulation MAPK15 TNF 9770326 538796 Furthermore , *induction* of p42/p44 ERK and [p38-MAPK] phosphorylation , c-jun kinase activation , and IkappaBalpha degradation were normal . Positive_regulation MAPK15 TNF 9883899 558203 *Activation* of p42/p44 mitogen activated protein kinases (MAPK) and p38 [MAPK] by is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation MAPK15 TNF 9883899 558218 Here , we demonstrate that is *sufficient* to activate p42/p44 [MAPK] and p38 MAPK . Positive_regulation MAPK15 TNF 9930718 588832 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Positive_regulation MAPK15 TNF 9931102 588899 ( 100 U/mL ) transiently *activated* [MAPK] with a maximal induction 10 minutes after stimulation that returned to baseline levels by 2 hours after treatment . Positive_regulation MAPK15 TNF 9931102 588912 PD98059 also blocked *stimulated* [MAPK] activation in a concentration dependent manner , which is consistent with its inhibition of TNF-alpha directed migration . Positive_regulation MAPK15 TNF 9931102 588925 To identify which TNF-alpha receptor is involved in *induced* [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Positive_regulation MAPK15 TNF 9931102 588951 VSMC express both receptors , but induced [MAPK] *activation* was inhibited only by the TNF-R1 antibody . Positive_regulation MAPK15 TNF 9931102 588977 Both TRO and RSG inhibited migration , but neither attenuated *induced* [MAPK] activation , indicating that their antimigration activity was exerted downstream of MAPK . Positive_regulation MAPK15 TNFSF10 12969966 1185565 Among the intracellular pathways investigated , significantly *stimulated* the extracellular signal regulated kinase 1/2 ( ERK1/2 ) but not the [p38/mitogen activated protein kinase (MAPK)] or the c-Jun NH2-terminal kinase (JNK) pathway . Positive_regulation MAPK15 TNFSF10 20951126 2364942 Taken together , this study provided first evidence demonstrating that , TNF-a- , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK15 TNFSF10 21152872 2373388 Taken together , we show herein that the upstream molecule of the *induced* [MAPK] activation is MEKK , as opposed to ASK1 , via the mediation of its signal through JNK/p38 in a caspase-8 dependent manner . Positive_regulation MAPK3 ADRB2 11018034 752791 induced p38 [MAPK] *activation* is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes . Positive_regulation MAPK3 ADRB2 12391272 1007510 lacking the cyclic AMP dependent protein kinase consensus sites fully *activates* [extracellular signal regulated kinase 1/2] in human embryonic kidney 293 cells : lack of evidence for G(s)/G(i) switching . Positive_regulation MAPK3 ADRB2 12509508 1038744 beta-Arrestin 1 is required for internalization and [mitogen activated protein (MAP) kinase] *activation* by the . Positive_regulation MAPK3 ADRB2 12582207 1058662 Beta-arrestin depletion in HEK293 cells leads to enhanced cAMP generation in *response* to stimulation , markedly reduced beta(2)-adrenergic receptor and angiotensin II receptor internalization and impaired activation of the MAP kinases [ERK 1] and 2 by angiotensin II . Positive_regulation MAPK3 ADRB2 16280323 1509406 beta-arrestin dependent , G protein independent [ERK1/2] *activation* by the . Positive_regulation MAPK3 ADRB2 19047375 2023485 Hematopoietic protein tyrosine phosphatase mediates *induced* regulation of p38 [mitogen activated protein kinase] in B lymphocytes . Positive_regulation MAPK3 ADRB2 9038193 415366 In the present work , we report that stimulation of the A2A-adenosine receptor and of the *activates* [mitogen activated protein kinase] ( MAP kinase ) in human endothelial cells based on the following criteria : adenosine analogues and beta-adrenergic agonists cause an ( i ) increase in tyrosine phosphorylation of the p42 isoform and to a lesser extent of the p44 isoform of MAP kinase and ( ii ) stimulate the phosphorylation of myelin basic protein by MAP kinase; (iii) this is accompanied by a redistribution of the enzyme to the perinuclear region . Positive_regulation MAPK3 ADRB2 9363896 462909 We show that in HEK293 cells , *stimulation* of [mitogen activated protein (MAP) kinase] by the is mediated by the betagamma subunits of pertussis-toxin-sensitive G proteins through a pathway involving the non-receptor tyrosine kinase c-Src and the G protein Ras . Positive_regulation MAPK3 ADRB2 9924018 588269 beta-Arrestin 1 mutants , impaired either in c-Src binding or in the ability to target receptors to clathrin coated pits , acted as dominant negative inhibitors of *mediated* activation of the MAP kinases [Erk1] and Erk2 . Positive_regulation MAPK3 ALOX5 11807011 903509 In contrast , stress induced product formation and translocation of <5-LO> , as well as *activation* of p38 [MAPK] , occurred also after Ca ( ++ ) depletion . Positive_regulation MAPK3 ALOX5 21200133 2391690 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Positive_regulation MAPK3 ANGPT1 12039842 954282 Accordingly , ephrinB2 inhibited VEGF- and *induced* [Ras-MAPK] activities , whereas ephrinB2 did not alter VEGF induced Flk phosphorylation or Ang1 induced Tie2 phosphorylation . Positive_regulation MAPK3 ANGPT1 12213710 985645 Both VEGF and *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 [MAPK] . Positive_regulation MAPK3 ANGPT1 12213726 985715 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of and Ang-2 as well as the *activation* of [MAPK] , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation MAPK3 ANGPT1 12824293 1113656 Inhibitors of the PI-3 kinase pathway attenuated *induced* [ERK1/2] phosphorylation at a level up-stream from Raf and MEK1/2 , but these inhibitors augmented Ang-1 induced p38 phosphorylation . Positive_regulation MAPK3 ANGPT1 12824293 1113659 We conclude that both anti- ( ERK1/2 ) and pro- ( p38 ) apoptotic members of MAPKs are simultaneously activated by in endothelial cells and that activation of [ERK1/2] by Ang-1 is *mediated* through the PI-3 kinase pathway . Positive_regulation MAPK3 ANGPT1 16049136 1459904 Overexpression of antioxidants ( superoxide dismutase and catalase ) and Rac1N17 , as well as preincubation with selective inhibitors of NADPH oxidase augmented basal p38 phosphorylation , inhibited Ang-1 induced PAK-1 phosphorylation and potentiated *induced* [Erk1/2] phosphorylation but had no influence on AKT and SAPK/JNK phosphorylation by Ang-1 . Positive_regulation MAPK3 ANGPT1 16061664 1439070 *activated* [mitogen activated protein kinase (MAPK)] and phosphoinositide 3-kinase (PI3K) in IBE cells and HUVECs . Positive_regulation MAPK3 ANGPT1 16679392 1612154 Pretreatment with either DPI or apocynin also significantly attenuated *induced* Akt and p44/42 [MAPK] phosphorylation . Positive_regulation MAPK3 ANGPT1 16679392 1612170 Using mouse heart microvascular endothelial cells from wild-type ( WT ) mice and mice deficient in the p47(phox) component of NADPH oxidase ( p47 ( phox-/- ) ) , we found that although *stimulated* intracellular ROS , Akt and p42/44 [MAPK] phosphorylation , and cell migration in WT cells , the responses were strikingly suppressed in cells from the p47 ( phox-/- ) mice . Positive_regulation MAPK3 ANGPT1 16714355 1612309 When vascular endothelial growth factor ( VEGF ) was present along with Ang-2 , ERK1/2 phosphorylation was inhibited , whereas augmentation of *induced* [ERK1/2] phosphorylation was triggered by VEGF . Positive_regulation MAPK3 ANGPT1 19615361 2124101 Treatment of HUVECs with the lipid raft disrupting agent methyl-beta-cyclodextrin selectively inhibited *induced* Akt phosphorylation , but not [Erk1/2] phosphorylation . Positive_regulation MAPK3 ANGPT1 20072135 2235288 *promoted* skin cell metabolism/viability , adhesion , and akt and [MAPK] ( p42/44 ) activations . Positive_regulation MAPK3 ANGPT1 24308939 2877827 differentially *induces* DUSP1 , DUSP4 , and DUSP5 in human umbilical vein endothelial cells through activation of the PI-3 kinase , [ERK1/2] , p38 , and SAPK/JNK pathways . Positive_regulation MAPK3 ANGPT1 24389129 2921733 Increased myocardial protein kinase C levels and loss of phosphorylation of [extracellular signal regulated kinase 1/2] were *prevented* by . Positive_regulation MAPK3 ANO1 22564524 2619163 *induces* [MAPK] and contributes directly to tumorigenesis and cancer progression . Positive_regulation MAPK3 ANO1 24823391 2945060 The expression or activation *increases* the phosphorylation of [ERK1/2] and decreases aromatase expression . Positive_regulation MAPK3 BPI 18055828 1833398 The authors recently reported that can *induce* [ERK1/2] and Akt activity and that it increases DNA synthesis in the bovine retinal pigment epithelial (RPE) and pericyte cells . Positive_regulation MAPK3 CAPN8 21543591 2424131 Downstream , an Aß-mediated rise in p38 [mitogen activated protein kinase (MAPK)] activation was followed by downregulation of cAMP response element binding protein , and LTP impairment was *prevented* by inhibitors of p38 MAPK or . Positive_regulation MAPK3 CAPN8 24416390 2900999 Treatment with glutamate leads to early activation of NMDAR , which in turn leads to mediated cleavage of striatal enriched protein tyrosine phosphatase ( STEP ) and subsequent *activation* of p38 [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK3 CCL17 23711854 2792900 IL-33 induced the production of thymus and activation regulated and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 [MAPK] . Positive_regulation MAPK3 CCND1 11004713 735018 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping [ERK-MAPK] activation and c-Fos and *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation MAPK3 CCND1 12654183 1072985 [MAPK] may *induce* overexpression of protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation MAPK3 CCND1 15020686 1221645 Double stranded small RNA interference ( siRNA ) by silencing endogenous p130Cas protein , was sufficient to inhibit estrogen dependent [Erk1/2] MAPKs activity and *induction* , demonstrating the requirement of p130Cas in such events . Positive_regulation MAPK3 CCND1 15634644 1349555 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 [mitogen activated protein kinase] , and down-regulation of . Positive_regulation MAPK3 CCND1 16522728 1531459 We conclude that incretin induced beta-cell replication is dependent on cAMP/PKA , p42 [MAPK] and PI3K activities , which may *involve* transcriptional induction of . Positive_regulation MAPK3 CCND1 17055752 1683908 The data showed overexpression of and increased expression and *activation* of [ERK1/2] , p38 kinase and JNK1/2 with progression of tumor suggesting that MAP kinases play an important role during tumorigenesis . Positive_regulation MAPK3 CCND1 19443725 2136037 EGF *induced* increases in paxillin Ser-126 phosphorylation and expression through transient [Erk1/2] phosphorylation . Positive_regulation MAPK3 CCND1 20694826 2430878 Cf-PS treatment induced the translocation of ß-catenin , an effector of the Wnt signaling pathway , from the cytosol to the nucleus and increased the expression of and c-myc. Cf-PS also *induced* [ERK1/2] phosphorylation , which is activated by mitogenic and proliferative stimuli such as growth factors , but the phosphorylation of JNK and p38 was not enhanced . Positive_regulation MAPK3 CCND1 22054946 2503952 Further , Cf-PS treatment induced the translocation of ß-catenin , an effector of the Wnt signaling pathway , from the cytosol to the nucleus and increased the expression of and c-myc. Cf-PS also *induced* [ERK1/2] phosphorylation , which is activated by mitogenic and proliferative stimuli such as growth factors , but the phosphorylation of JNK and p38 was not enhanced . Positive_regulation MAPK3 CCND1 24375433 2917202 While secondary stimulation resulted in strongly decreased replication rate , we did not observe any attenuation of morphological changes , [Erk1/2] phosphorylation and *induction* . Positive_regulation MAPK3 CCND1 9537433 497562 Furthermore , in 25 of 26 cases of HCC which genomic DNA was available , 22 cases without genomic DNA amplification exhibited positive correlation , not only between protein expression of c-Fos and , but also between [MAPK/ERK] *activation* and cyclin D1 expression . Positive_regulation MAPK3 CD14 15625444 1349238 LPS interacts with the cell surface receptor , which generates transmembrane signals through Toll-like protein 4 *leading* to [mitogen activated protein kinase (MAPK)] p38 activation , cytokine synthesis , PMN beta2-integrin expression and oxidative burst . Positive_regulation MAPK3 CD14 22561121 2608688 Zaprinast was found to activate [ERK1/2] , p38 MAPK , JNK , NF?B , and PI3K/Akt , and subsequently , *induce* the mRNA expressions of IL-1a , IL-1ß , TNF-a , CCL2 , CCL4 , CXCL1 , CXCL2 , and . Positive_regulation MAPK3 CHI3L1 23755018 2797729 In addition , *induces* [FAK-MAPK] signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation MAPK3 CHI3L1 23972995 2836241 We also demonstrate that *activates* macrophage [mitogen activated protein kinase] , protein kinase B/AKT , and Wnt/ß-catenin signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation MAPK3 CLU 23051594 2702818 FOXL2 directly stimulates the Clu gene promoter , and we show that PTTG triggers ataxia telangiectasia mutated [kinase/IGF-I/p38MAPK] DNA damage/chromosomal instability signaling , which in turn also *induces* expression . Positive_regulation MAPK3 CTGF 11732999 885264 *induces* chondrocyte differentiation through a p38 [mitogen activated protein kinase] ( p38MAPK ) , and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase ( ERK ) . Positive_regulation MAPK3 CTGF 11732999 885278 In the proliferation phase , *induced* a approximately fivefold increase in the phosphorylation of p44/42 [MAPK/ERK] and a approximately twofold increase in that of p38 MAPK in an in vivo kinase assay . Positive_regulation MAPK3 CTGF 12218048 1012164 The inhibition of *induced* p42/44 [MAPK] or phosphatidylinositol 3-kinase (PI3K)/protein kinase B pathway activities abrogated the induction of fibronectin expression . Positive_regulation MAPK3 CTGF 16408113 1513479 *enhanced* the mRNA expression and protein release of fractalkine , MCP-1 , and RANTES , the expression of phospho ( P ) -p42/44 [mitogen activated protein kinase (MAPK)] , P-phosphoinositide 3-kinase (PI3-K) , P-Akt , and activity of nuclear factor-kappaB (NF-kappaB) in mesangial cells . Positive_regulation MAPK3 CTGF 16408113 1513511 P-p42/44 MAPK blockade inhibited the *induced* expression of P-p42/44 [MAPK] but not NF-kappaB , and partially decreased the levels of the above chemokines in supernatants . Positive_regulation MAPK3 CTGF 16522717 1531327 ( 3 ) *stimulated* dose dependent HSC adhesion and activity of p42/p44 [mitogen activated protein kinase] , the latter of which was antagonized by blocking the activity of focal adhesion kinase . Positive_regulation MAPK3 CTGF 16813525 1580705 was critically involved in osteolytic metastasis and was *induced* by PKA- and PKC dependent activation of [ERK1/2] signaling by PTHrP . Positive_regulation MAPK3 CTGF 16877704 1600907 Most interestingly , overexpression of *suppressed* insulin-like growth factor-I dependent Akt phosphorylation and epidermal growth factor dependent [extracellular signal regulated kinase 1/2] phosphorylation . Positive_regulation MAPK3 CTGF 16938382 1654126 No single module , but a mixture of the 4 modules provoked a significant activation of p38 [MAPK] in HCS-2/8 cells , which was *activated* by the full-length . Positive_regulation MAPK3 CTGF 16950763 1673312 PD-98059 inhibited *induced* proliferation ( -12 +/- 3 % , P < 0.05 ) and [ERK1/2] phosphorylation ( -34 +/- 5 % , P < 0.05 ) in tumor cells . Positive_regulation MAPK3 CTGF 17550972 1752625 A neutralizing antibody against integrin alphavbeta3 significantly attenuated mediated [ERK1/2] *activation* and cellular migration , indicating that the integrin-alphavbeta3-ERK1/2 signaling pathway is crucial in mediating CTGF function . Positive_regulation MAPK3 CTGF 19011018 2047244 *increased* the phosphorylation of p38 and [ERK1/2] . Positive_regulation MAPK3 CTGF 19038999 2023087 Interestingly , CCN2-BMP-2 did not affect the *induced* phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Positive_regulation MAPK3 CTGF 19307750 2086985 Calcitonin *induces* through [ERK1/2] signaling in renal tubular cells . Positive_regulation MAPK3 CTGF 19307750 2086986 Our present findings suggest that CT *induces* the transcription of through [ERK1/2] phosphorylation . Positive_regulation MAPK3 CTGF 19351859 2057721 A neutralizing antibody against integrin alpha(v)beta(3) significantly attenuated mediated [ERK1/2] *activation* and up-regulation of Bcl-xL and cIAP1 , indicating that the integrin alpha(v)beta(3)/ERK1/2 signaling pathway is essential for CTGF functions . Positive_regulation MAPK3 CTGF 19378419 2007967 PI3-K blockade downregulated the *stimulated* expressions of phosphorylated PI3-K , PKB and NF-kappaB but not phosphorylated [ERK1/2] , partially decreased the expressions of the above chemokines . Positive_regulation MAPK3 CTGF 20008146 2191215 Moreover , we found that *induced* the expression of alpha2AP through both the [extracellular signal regulated kinase 1/2] ( ERK1/2 ) and c-Jun N-terminal kinase (JNK) pathways in fibroblasts . Positive_regulation MAPK3 CTGF 20201953 2259340 Additional experiments showed that *induces* phosphorylation of [ERK1/2] , Ets1 and c-Jun. Consistent with the stimulatory role of ERK1/2/Ets1 in the expression of MMP1 , the ERK1/2 inhibitor UO126 prevented the phosphorylation of ERK1/2 and Ets1 and completely abrogated the induction of MMP1 after CCN2 overexpression , while having no effect on c-Jun activation . Positive_regulation MAPK3 CTGF 20213804 2249226 *induced* phosphorylation of p38 , [ERK-1/2] , JNK , and Akt , but not Smad3 , in transgenic mouse fibroblasts compared with wild-type mouse fibroblasts . Positive_regulation MAPK3 CTGF 21645240 2579215 In tibialis anterior muscle overexpressing CTGF using an adenovirus , ARB treatment decreased *mediated* increase of ECM molecules , a-SMA and [ERK-1/2] phosphorylation levels . Positive_regulation MAPK3 CTGF 21760921 2456300 Recombinant *activated* Src and [Erk1/2] signaling , and induced phosphorylation of Fli1 , but was unable to stimulate Smad1 or Smad3 phosphorylation . Positive_regulation MAPK3 CYP24A1 15836435 1432542 Using HEK-293T cells ( human embryonic kidney 293T cells ) , we reported that 1,25D induction of *requires* JNK ( c-Jun N-terminal kinase ) but not the [ERK1/2] ( extracellular-signal regulated kinase 1/2 ) . Positive_regulation MAPK3 EDN2 12193071 980937 The molecular mechanisms of dependent *activation* of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Positive_regulation MAPK3 EDN2 12475899 1037775 *induced* a rapid phosphorylation of the [mitogen activated protein kinase (MAPK)/ERK] and increased collagen I gene activity in freshly isolated aortas . Positive_regulation MAPK3 EDN2 1280103 203042 rapidly *stimulates* [mitogen activated protein kinase] activity in rat mesangial cells . Positive_regulation MAPK3 EDN2 12855582 1149893 also *induced* the activation of p42/44 [mitogen activated protein kinase (MAPK)] in DCs . Positive_regulation MAPK3 EDN2 15662221 1365136 Moreover , did not *enhance* the phosphorylation of [ERK 1/2] in small mesenteric arteries . Positive_regulation MAPK3 EDN2 7509933 241609 *stimulates* [mitogen activated protein kinase] p42 activity through the phosphorylation of the kinase in rat mesangial cells . Positive_regulation MAPK3 EDN2 7849246 286733 *stimulates* [mitogen activated protein kinase] activity in mesangial cells through ETA . Positive_regulation MAPK3 EDN2 7943276 276400 has been shown to *activate* [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK3 EDN2 8836145 386174 In bovine airway smooth-muscle cells platelet derived growth factor ( PDGF ) and ( Et-1 ) *stimulate* sustained and comparable activation of [mitogen activated protein kinase] ( MAP kinase ) but display very different mitogenic efficacies , with PDGF inducing 50 times more DNA synthesis than Et-1 . Positive_regulation MAPK3 EFNB1 15502157 1347562 Further downstream of the signaling pathway , stimulation *led* to increased LAT ( linker for activation of T-cells ) phosphorylation and p44/42 and p38 [MAPK] activation . Positive_regulation MAPK3 EPHB2 10601128 574210 Tumor necrosis factor-alpha (TNF-alpha) alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only . Positive_regulation MAPK3 EPHB2 10725339 677553 The complex , which contains internalized receptor , beta-arrestin , raf-1 , and activated , is *required* for [ERK1/2] activation . Positive_regulation MAPK3 EPHB2 10872747 707027 Pre-treatment of the cells with PD98059 , a selective pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation MAPK3 EPHB2 10898713 712109 H ( 2 ) O ( 2 ) mediates changes in [ERK1/ERK2] phosphorylation , increases endothelial solute permeability , and alters occludin localization and phosphorylation were all *blocked* by PD-98059 , a specific mitogen activated protein ( MAP ) or kinase 1 inhibitor . Positive_regulation MAPK3 EPHB2 11083274 750493 Tumor necrosis factor alpha , interleukin-1 (IL-1) , and IL-6 were the major inducers of , JNK , and p38 [MAPK] *activation* in cultured human synovial cells . Positive_regulation MAPK3 EPHB2 11886455 919951 A kinase inhibitor , PD098059 , decreased the basal levels of phospho-ERK1/2 and *prevented* the increase in [ERK1/2] phosphorylation induced by depolarization . Positive_regulation MAPK3 EPHB2 12062026 952956 Our results reveal an unexpected complexity of dependent signaling in the brain and a critical regulatory *role* for [ERK1] in the long-term adaptive changes underlying striatum dependent behavioral plasticity and drug addiction . Positive_regulation MAPK3 EPHB2 12220664 987054 The inhibitor of activation PD98059 abolished caspase activation , but caspase inhibition did not *reduce* [ERK 1/2] phosphorylation , suggesting that ERK activation is placed upstream of caspases . Positive_regulation MAPK3 EPHB2 12354421 993598 Specific kinase inhibitor PD98059 *inhibited* IgM-AECA induced [ERK1/2] activities and ICAM-1 expression on HDMEC at a concentration of 60 microM . Positive_regulation MAPK3 EPHB2 12386816 999765 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 [MAPK] and a biphasic *activation* of . Positive_regulation MAPK3 EPHB2 12403788 1036183 SB203580 , a p38 [MAPK] *inhibitor* , and PD98059 , an inhibitor , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation MAPK3 EPHB2 12486127 1056310 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain *had* little effect on basal Erk [MAPK] activation . Positive_regulation MAPK3 EPHB2 12511425 1070739 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation MAPK3 EPHB2 12801927 1120234 GE2 stimulation *induced* phosphorylation , whereas it did not alter the phosphorylation of c-Jun N-terminal kinase or p38 [MAPK] . Positive_regulation MAPK3 EPHB2 12832293 1105579 Exposure to E. coli DNA resulted in phosphorylation of ERK 1/2 [MAPK] and inhibitors of activity ( PD98059 , UO126 ) significantly *reduced* the evoked IL-8 production . Positive_regulation MAPK3 EPHB2 12878192 1115521 ( 2 ) the *activation* of JNK and p38 [MAPK] but not in embryonic fibroblasts ( MEFs ) derived from ASK1 knockout mice ( ASK1 ( -/- ) MEFs ) was depressed compared to MEFs derived from wild type mice ( ASK1 ( +/+ ) MEFs ) ; Positive_regulation MAPK3 EPHB2 14973553 1212666 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen activated protein kinase (MAPK)] signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation MAPK3 EPHB2 14998726 1216732 Furthermore , we found that PD98059 , an pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation MAPK3 EPHB2 15086566 1237650 Inhibition of mitogen and with U0126 and phosphoinositide 3-OH kinase *attenuated* BrdU incorporation and [ERK1/2] activation . Positive_regulation MAPK3 EPHB2 15328027 1287631 Thus , hypoxia concurrently triggered both JNK and signaling , and with reoxygenation , [ERK1] activation and stem cell proliferation *followed* by neuronal progenitor cell differentiation and targeted migration to the site of pyramidal neuronal loss . Positive_regulation MAPK3 EPHB2 15659876 1350311 The anabolic effect of TNF-alpha was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an . Positive_regulation MAPK3 EPHB2 15969741 1440954 [ERK1/2] but not JNK and p38 were activated by GTS-21 , and the phosphorylation inhibitors PD98059 and U0126 *blocked* protection . Positive_regulation MAPK3 EPHB2 16038626 1437423 SF significantly prevented Abeta induced increases in IL-1beta and p38 [MAPK] *activation* and also Abeta induced changes in and phospho-Akt/PKB expression levels . Positive_regulation MAPK3 EPHB2 17056059 1649529 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Positive_regulation MAPK3 EPHB2 17396111 1760658 An kinase inhibitor significantly *reduced* the renin induced [ERK1/2] phosphorylation and the subsequent increase in transforming growth factor-beta1 ( TGF-beta1 ) and plasminogen activator inhibitor-1 mRNA expression . Positive_regulation MAPK3 EPHB2 17403539 1735936 Trauma-hemorrhage increased the production of IL-6 , IL-10 , IL-12 and TNF-alpha enhanced the expression of TLR4 , MyD88 as well as the *activation* of [MAPK] proteins ( p38 , and JNK ) in epidermal keratinocytes . Positive_regulation MAPK3 EPHB2 17416211 1777895 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK3 EPHB2 17464174 1731747 The mRNA and surface protein up-regulation of CCR1 and CCR2 in 9CRA stimulated cells were weakly blocked by the pretreatment of SB202190 , a p38 [MAPK] *inhibitor* , and PD98059 , an upstream inhibitor . Positive_regulation MAPK3 EPHB2 17700518 1865978 PEA-15 regulates the level of phosphorylated in glioblastoma cells and the PEA-15 dependent protection from glucose deprivation induced cell death *requires* [ERK1/2] signaling . Positive_regulation MAPK3 EPHB2 17879163 1818406 Treatment with V+H- decreased the phosphorylation of extracellular signal regulated kinase ( ERK ) 1 and 2 , and direct activation of by constitutively active MEK1 , an ERK kinase , *increased* [ERK1] and ERK2 phosphorylation and inhibited the increase in apoptosis induced by V+H- . Positive_regulation MAPK3 EPHB2 18006496 1851667 Previous work with the angiotensin AT1a receptor has shown that G ( q/11 ) activation leads to a rapid and transient rise in ERK1/2 activity , whereas beta-arrestin binding supports sustained [ERK1/2] *activation* by scaffolding a Raf . MEK . complex associated with the internalized receptor . Positive_regulation MAPK3 EPHB2 18164124 1869612 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 [MAPK] , but not by the *activation* of JNK , , and NF-kappaB pathway . Positive_regulation MAPK3 EPHB2 18266967 2000304 VEGF induced activation of p42 also *led* to the nuclear translocation of [MAPK/ERK1/2] . Positive_regulation MAPK3 EPHB2 18285354 1885408 Pre-treatment with the [MAPK] *inhibitors* SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( inhibitor ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation MAPK3 EPHB2 18338254 1938060 Interestingly , inhibition of by U0126 completely *prevented* artepillin C-induced p38 [MAPK] phosphorylation of PC12m3 cells . Positive_regulation MAPK3 EPHB2 18463290 1910072 Using 293A cells and in vitro experiments , we detail the formation of a ternary complex of , *activation* of MEK1 and [ERK1/2] kinase activities by hBVR , and phosphorylation of hBVR by ERK1/2 . Positive_regulation MAPK3 EPHB2 18520049 1918675 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of , rather than by the *activation* of p38 [MAPK] , in the spinal cord . Positive_regulation MAPK3 EPHB2 18982426 2105749 These inhibitory effects were partially inhibited by SB203580 , a specific *inhibitor* of p38 [MAPK] , but not by PD98059 , a specific inhibitors of extracellular signal regulated kinase ( ) , and SP600125 , a specific inhibitor of c-Jun-N-terminal kinase (JNK) . Positive_regulation MAPK3 EPHB2 19189219 2113964 Moreover , EM1 treatment resulted in less activation of p38 [MAPK] and more *activation* of signaling in lipopolysaccharide stimulated DCs . Positive_regulation MAPK3 EPHB2 19276187 2051420 Treatment of cells with sphingosine induced suppression of and *activation* of p38 [MAPK] . Positive_regulation MAPK3 EPHB2 19429670 2106923 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either inhibitor , [p38MAPK] *inhibitor* or NF-kappaB inhibitor . Positive_regulation MAPK3 EPHB2 19522739 2103143 Treatment with [MAPK] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation MAPK3 EPHB2 19641719 1358727 IGF-1 *induced* an increase in phosphorylated [extracellular signal regulated kinase 1/2] ( ) , but did not change ERK protein content in cardiomyocytes . Positive_regulation MAPK3 EPHB2 19672126 2168071 A scratch wound assay of healing rates in SV40 immortalized human corneal epithelial cell line ( HCEC ) evaluated the relative contributions by p38 and and JNK [MAPK] signaling *activation* to wound healing . Positive_regulation MAPK3 EPHB2 19836351 2165141 EGFR-mutant non-small cell lung cancer cell lines constitutively express active [ERK1/2] and *require* activity for survival . Positive_regulation MAPK3 EPHB2 20025124 2175515 Prior treatment of the cells with PD98059 , an kinase inhibitor or SB203580 , a [p38MAPK] *inhibitor* , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation MAPK3 EPHB2 20554538 2327624 The HNE enhanced Sp1 and NF-?B activities were attenuated by SB203580 , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , and PD98059 , an extracellular signal regulated kinase ( ) inhibitor , respectively . Positive_regulation MAPK3 EPHB2 21126656 2355801 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 [mitogen activated protein kinase] , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by . Positive_regulation MAPK3 EPHB2 21311676 2360036 Treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation MAPK3 EPHB2 21488184 2417975 Dexmedetomidine induced phosphorylation of JNK and p38 [MAPK] in rat aortic SMCs , but did not *induce* phosphorylation of . Positive_regulation MAPK3 EPHB2 21586573 2449668 Incubation of T cells with ESAT-6 induced phosphorylation and increased functional p38 [MAPK] activity , but not *activation* of or JNK . Positive_regulation MAPK3 EPHB2 21599960 2445730 In the present studies , induction of central sensitization as indicated by spinal dorsal horn [MAPK] *activation* , specifically and p38 phosphorylation , was assessed in the MIA-OA model . Positive_regulation MAPK3 EPHB2 21813685 2462764 We show that the activation of receptors required for I-LTD increased [ERK1/2] phosphorylation and inhibitors of activation *blocked* I-LTD . Positive_regulation MAPK3 EPHB2 23394443 2713240 When compared to hamsters bearing tumors that remained on the control diet , the buccal pouches of hamsters bearing tumors receiving turmeric showed the following results : ( 1 ) decreased cell proliferation ( diminished PCNA , cyclin D1 , and Bcl-2 ) and PCNA labelling index , ( 2 ) enhanced apoptosis ( increased Bax , caspase-3 , caspase-9 , and cytochrome c , and decreased survivin ) and apoptotic index , ( 3 ) decreased inflammation ( decreased Cox-2 ) , and ( 4 ) decreased [MAPK] *activation* ( and p-p38 ) . Positive_regulation MAPK3 EPHB2 23892041 2830337 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three [MAPK] *inhibitors* ( inhibitor PD98059 , JNK inhibitor SP600125 and p38 inhibitor SB203580 ) . Positive_regulation MAPK3 EPHB2 23914844 2840573 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 [MAPK] and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of , JNK , NF-?B . Positive_regulation MAPK3 EPHB2 23917355 2826035 Inhibition of Akt or activity *reduced* phosphorylation of STAT1 in Colon26L5-CUG2 cells whereas inhibition of p38 [MAPK] did not significantly decrease levels of STAT1 phosphorylation , indicating that cell proliferation signals may be involved in CUG2 mediated activation of STAT1 . Positive_regulation MAPK3 EPHB2 23919615 2826241 Treatment of quiescent HIEC with serum *induced* [ERK1/2] activation , E2F4 phosphorylation , E2F4 nuclear translocation and G1/S phase transition while inhibition of signaling by U0126 prevented these events . Positive_regulation MAPK3 EPHB2 24225419 2897497 Therefore , by using the [MAPK] *inhibitors* SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific inhibitor ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation MAPK3 EPHB2 24297112 2894223 Following treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation MAPK3 EPHB2 8444886 213735 [ERK1] could also be *activated* by the activator to the same extent . Positive_regulation MAPK3 F2R 15383630 1299012 Finally , PAR1 activation induces Src phosphorylation , which is reversed by using the Src tyrosine kinase inhibitor PP2 , suggesting that Src activation plays a permissive role for mediated [ERK1/2] *activation* and cell proliferation probably acting downstream of the EGFR . Positive_regulation MAPK3 F2R 16052512 1460027 The p38 and ERK1/2 [MAPK] signaling cascades were also *activated* by stimulation , whereas the SAPK/JNK pathway was unaffected . Positive_regulation MAPK3 F2R 16467309 1548157 and PAR-2 stimulation rapidly *activated* both ERK1/2 and [p38MAPK] , and pharmacological blockade of MEK with either PD98059 or U0126 or of p38MAPK by SB203580 or SB202190 strongly inhibited thrombin- and SLIGKV induced COX-2 expression and 6-keto-PGF1alpha formation . Positive_regulation MAPK3 F2R 19683795 2208953 The EPCR dependent cleavage of by both APC and thrombin *increased* the phosphorylation of [ERK 1/2] . Positive_regulation MAPK3 F2R 20215560 2259581 Both receptors stimulated extracellular signal regulated kinase ( ERK) 1/2 phosphorylation , but only *inhibited* adenylyl cyclase activity , and pertussis toxin blocked PAR1 effects on both adenylyl cyclase and [ERK1/2] signaling . Positive_regulation MAPK3 F2R 21252088 2402887 In the present study , we show that FVIIa , upon binding to EPCR on endothelial cells , activates endogenous protease activated receptor-1 (PAR1) and induces mediated p44/42 [mitogen activated protein kinase (MAPK)] *activation* . Positive_regulation MAPK3 F2R 23476015 2771781 Moreover , thrombin activated PAR1-PAR2 heterodimers enhance ß-arrestin mediated ERK1/2 activation in the cytoplasm , whereas activated [ERK1/2] *induced* by the thrombin activated protomer redistributes to the nucleus . Positive_regulation MAPK3 F2R 24052258 2867018 However , the distinct non-canonical tethered ligands unmasked by neutrophil elastase and proteinase-3 , as well as synthetic peptides with sequences derived from these novel exposed tethered ligands , selectively stimulated mediated [mitogen activated protein kinase] *activation* . Positive_regulation MAPK3 F2R 8380983 210191 Differential *activation* of [p44mapk] ( ERK1 ) by alpha-thrombin and peptide agonist . Positive_regulation MAPK3 F2R 8635212 357939 These results support the notion that the *activates* [MAPK] through PKC dependent pathways and that the incremental activation of MAPK by TRAP over that induced by thrombin is the consequence of enhanced activation through the PKC limb of the phosphoinositide lipid pathway . Positive_regulation MAPK3 FAS 14576831 1156607 A more physiological inhibitor , the intracellular PP2A inhibitor protein I2 ( PP2A ) , protected transfected HeLa cells in a similar way from mediated apoptosis and induced *activation* of [MAPK] in I2 ( PP2A ) transfected cells . Positive_regulation MAPK3 FAS 15280387 1302534 We further demonstrate that this pro-apoptotic effect of CO was independent of reactive oxygen species production and involved inhibition in induced *activation* of the pro-survival ERK [MAPK] . Positive_regulation MAPK3 FAS 16507991 1529639 Here we show that binding of Fas ligand to *activates* p38 [MAPK] in CD8+ T cells and that activation of this pathway is required for Fas mediated CD8+ T-cell death . Positive_regulation MAPK3 FAS 19417161 2179812 GST-MDA-7 killing was , in parallel , dependent on inactivation of extracellular signal regulated kinase 1/2 and on *induced* p38 [mitogen activated protein kinase] and c-jun NH ( 2 ) -terminal kinase-1/2 signaling . Positive_regulation MAPK3 FAS 21613257 2454278 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Positive_regulation MAPK3 FAS 21975294 2492845 Caspase-8 activity has an essential role in mediated [MAPK] *activation* . Positive_regulation MAPK3 FAS 23089915 2717162 In parallel , activation *increased* phosphorylation of [ERK1/2] , and FasL induced lipolysis was blunted in the presence of the ERK-inhibitor U0126 or in ERK1/2 depleted adipocytes . Positive_regulation MAPK3 FAS 8977313 403348 IFN-alpha2 did not alter the *induced* activity of [Mitogen activated protein kinase (MAPK)] 1 and did not inhibit the Apo-1/Fas mediated proteolytic cleavage of ADP-ribosyltransferase , a substrate of Interleukin-beta1 converting enzyme ( ICE ) and homologues . Positive_regulation MAPK3 FHL1 23456229 2781819 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Positive_regulation MAPK3 FLG 17045653 1666566 Likewise , neither FTI-277 nor GW 5074 had any effect on *mediated* activation of [ERK1/2] . Positive_regulation MAPK3 FOXA1 22879989 2641684 An increase in IGFBP-3 , mediated by depletion of , *inhibited* phosphorylation of [MAPK] and Akt , and increased expression of the cell cycle regulators p21 and p27 . Positive_regulation MAPK3 FOXO1 23888319 2902020 In addition , we showed that curcumin *induced* the expression of through activation of [extracellular signal regulated kinase 1/2] signaling . Positive_regulation MAPK3 FUT4 20506505 2307957 These data suggested that not only *activates* [MAPK] and PI3K/Akt signals , but also promotes the crosstalk among these signaling pathways . Positive_regulation MAPK3 FUT4 21337384 2411176 The results showed that overexpression *up-regulated* phosphorylation of [ERK1/2] and Akt which was inhibited by CPA in dose dependent manner . Positive_regulation MAPK3 GLP1R 16931572 1646425 Finally , *stimulated* activation of [ERK1/2] , which involves transactivation of epidermal growth factor receptors , required lipid raft integrity . Positive_regulation MAPK3 GLP1R 21356521 2394817 activation by Exendin-4 ( Ex-4 ) *increased* PKA and [MAPK] activity and decreased phosphorylation of AMPK in NTS . Positive_regulation MAPK3 GPR115 10958680 725609 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK3 GPR115 11695994 877200 Src-family tyrosine kinases , phosphoinositide 3-kinase and Gab1 regulate [extracellular signal regulated kinase 1] activation *induced* by the type A endothelin-1 . Positive_regulation MAPK3 GPR115 11916960 945361 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK3 GPR115 18211822 1870774 Recent studies have demonstrated that the mitogenic effects of LDL are accompanied by [Erk1/2] *activation* via an unknown . Positive_regulation MAPK3 GPR115 20576526 2303083 In many cell types , induced [Erk1/2] MAP kinase *activation* is mediated via receptor tyrosine kinase ( RTK ) transactivation , in particular via the epidermal growth factor (EGF) receptor . Positive_regulation MAPK3 GPR115 9182581 435555 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK3 GPR115 9826186 549952 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK3 GPR132 10958680 725598 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK3 GPR132 11474113 841740 Activation of by LPC *increased* intracellular calcium concentration , induced receptor internalization , activated ERK [mitogen activated protein kinase] , and modified migratory responses of Jurkat T lymphocytes . Positive_regulation MAPK3 GPR132 11695994 877189 Src-family tyrosine kinases , phosphoinositide 3-kinase and Gab1 regulate [extracellular signal regulated kinase 1] activation *induced* by the type A endothelin-1 . Positive_regulation MAPK3 GPR132 11916960 945350 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK3 GPR132 18211822 1870763 Recent studies have demonstrated that the mitogenic effects of LDL are accompanied by [Erk1/2] *activation* via an unknown . Positive_regulation MAPK3 GPR132 20576526 2303072 In many cell types , *induced* [Erk1/2] MAP kinase activation is mediated via receptor tyrosine kinase ( RTK ) transactivation , in particular via the epidermal growth factor (EGF) receptor . Positive_regulation MAPK3 GPR132 9182581 435544 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK3 GPR132 9826186 549941 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK3 GPR87 10958680 725678 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK3 GPR87 11695994 877271 Src-family tyrosine kinases , phosphoinositide 3-kinase and Gab1 regulate [extracellular signal regulated kinase 1] activation *induced* by the type A endothelin-1 . Positive_regulation MAPK3 GPR87 11916960 945430 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK3 GPR87 18211822 1870843 Recent studies have demonstrated that the mitogenic effects of LDL are accompanied by [Erk1/2] *activation* via an unknown . Positive_regulation MAPK3 GPR87 20576526 2303152 In many cell types , *induced* [Erk1/2] MAP kinase activation is mediated via receptor tyrosine kinase ( RTK ) transactivation , in particular via the epidermal growth factor (EGF) receptor . Positive_regulation MAPK3 GPR87 9182581 435624 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on mediated *activation* of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK3 GPR87 9826186 550021 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK3 HBEGF 10544013 563925 also rapidly *activated* [MAPK] and induced cyclin D1 in mid-G1 with kinetics similar to TGFalpha . Positive_regulation MAPK3 HBEGF 11171084 783796 Both p42 [MAPK] activation and mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation MAPK3 HBEGF 15143154 1273157 Consistent with its agonist action , stimulation of these cells *caused* marked phosphorylation of the EGF-R and its adapter molecule , Shc , as well as [ERK1/2] and its dependent protein , p90 ribosomal S6 kinase , in a manner similar to that elicited by Ang II or EGF . Positive_regulation MAPK3 HBEGF 15380451 1298482 *induced* phosphorylation of ERK , p38 [MAPK] and Akt , which were suppressed by ZD1839 . Positive_regulation MAPK3 HBEGF 16336626 1503766 Phe induced phosphorylation of the EGF-R , and subsequently of Shc and [ERK1/2] , was *attenuated* by inhibition of MMP or with the selective inhibitor , CRM197 , or by a neutralizing antibody . Positive_regulation MAPK3 HBEGF 17107942 1700421 directly *activated* [ERK1/2] in HEK-293 cells . Positive_regulation MAPK3 HBEGF 17761534 1807947 also *induced* early activation of [ERK1/2] in JM-a/CYT-2 cells and promoted nuclear translocation of the JM-a/CYT-2 cytoplasmic tail . Positive_regulation MAPK3 HBEGF 17928891 1858626 We report that cellular stress with methyl-beta-cyclodextrin ( MBCD ) , a molecule that extracts membrane cholesterol and thereby disrupts the structure of lipid rafts , strongly *induces* the synthesis of ( HB-EGF ) in keratinocytes through the activation of p38 [mitogen activated protein kinase] . Positive_regulation MAPK3 HBEGF 18990151 2028925 *Activation* of [Erk/MAPK] by was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation MAPK3 HBEGF 19048624 2023718 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked MAPK signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 [MAPK] , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Positive_regulation MAPK3 HBEGF 19559571 2110506 *induced* phosphorylation of p42/p44 [MAPK] in a few minutes . Positive_regulation MAPK3 HBEGF 20739666 2345891 Moreover , *induced* a stronger and more sustained activation of both the [mitogen activated protein kinase] and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation MAPK3 HBEGF 22873932 2647093 Phosphoimmunoblotting of PCMOs indicated that both EGF and *activated* MEK-1/2 and [ERK1/2] in a concentration dependent fashion with the effect of EGF being more prominent . Positive_regulation MAPK3 HBEGF 24188029 2921106 Here , we show that *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , [Mapk/Erk] pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation MAPK3 HRH1 11959800 931443 1. Previous studies have shown that the *activates* p42/p44 [mitogen activated protein kinases (MAPK)] in DDT ( 1 ) MF-2 smooth muscle cells via a phosphatidylinositol 3-kinase (PI-3K) dependent pathway . Positive_regulation MAPK3 HRH1 17965772 1820341 is *required* for TCR mediated p38 [MAPK] activation and optimal IFN-gamma production in mice . Positive_regulation MAPK3 HRH1 17965772 1820355 Moreover , signaling at the time of TCR ligation was *required* for activation of p38 [MAPK] , a known regulator of IFN-gamma expression . Positive_regulation MAPK3 HRH1 19913013 2197723 On the other hand , *induced* [ERK1/2] activation was inhibited by U73122 but not affected by C3 or beta2-chimaerin , suggesting that ERK1/2 activation was dependent on PLC and independent of RhoA or Rac . Positive_regulation MAPK3 ID1 15870857 1404883 Incubation with BMP-2 under serum-free conditions induced *activation* of the mitogen activated protein kinases ( MAPKs ) [ERK1/2] and the basic helix-loop-helix transcription factors , proteins that can protect from apoptosis . Positive_regulation MAPK3 IFI27 16953232 1682584 RET2A mediated regulation of p18 and , but not of cyclins D1 and D2 , *requires* functional [mitogen activated protein kinase] signaling . Positive_regulation MAPK3 IFI27 18057711 1833792 OR-heparin also inhibited high glucose activated [ERK1/2] phosphorylation , *induced* ( Kip1 ) expression , and suppressed reactive oxygen species ( ROS ) accumulation in a dose dependent manner . Positive_regulation MAPK3 IFI27 21312237 2398701 WIN 55,212-2 also upregulated [phospho-ERK1/2] , *induced* and Cip1/WAF1/p21 expression , decreased cyclin D1 and cyclin E expression , decreased Cdk 2 , Cdk 4 , and Cdk 6 expression levels , and decreased phospho-Rb and E2F-1 expression . Positive_regulation MAPK3 IGFBP1 21940708 2539285 *induced* activation of [ERK1/2] ( MAPK3/1 ) , which did not require RHO proteins , might function as an alternate pathway for RHO action . Positive_regulation MAPK3 IL1B 10640438 577508 and TNF alpha also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK3 IL1B 10704772 673007 CPI-1189 inhibits *induced* [p38-mitogen activated protein kinase] phosphorylation : an explanation for its neuroprotective properties ? Positive_regulation MAPK3 IL1B 10775561 686646 *activated* p44/42 [MAPK] , and this activation was enhanced in the presence of N-acetyl-L-cysteine . Positive_regulation MAPK3 IL1B 10864897 705730 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK3 IL1B 10864897 705782 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by TNF-alpha and . Positive_regulation MAPK3 IL1B 10864897 705800 TNF-alpha- and *induced* [ ( 3 ) H ] -thymidine incorporation and phosphorylation of p42/p44 [MAPK] was completely inhibited by PD98059 ( an inhibitor of MEK1/2 ) , indicating that activation of MEK1/2 was required for these responses . Positive_regulation MAPK3 IL1B 10903806 713227 It has been reported recently that *induces* activation of the mitogen activated protein kinases (MAPK) p38 and [ERK1/2] in neonatal rat islets . Positive_regulation MAPK3 IL1B 10903806 713237 We conclude that *induces* activation of both p38 and [ERK1/2] , and that ERK1/2 contributes to the pro-apoptotic effects of the cytokine in primary beta-cells . Positive_regulation MAPK3 IL1B 10960082 726353 [ERK1/2] *activation* by was sensitive to inhibition by the PKC inhibitor bisindolylmaleimide suggesting that ERK phosphorylation is a downstream signal of PKC activation . Positive_regulation MAPK3 IL1B 10969830 728488 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Positive_regulation MAPK3 IL1B 11032891 740456 *induces* p38 [MAPK] phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation MAPK3 IL1B 11037878 741243 also *stimulated* phosphorylation of p38 [MAPK] , SAPK/JNK , and ATF-2 . Positive_regulation MAPK3 IL1B 11126408 759775 TNFalpha and IFNgamma potentiate *induced* [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK3 IL1B 11126408 759788 [Mitogen activated protein kinase (MAPK)] activity that is *induced* by has been suggested to signal nitric oxide dependent as well as nitric oxide independent beta-cell destructive pathways . Positive_regulation MAPK3 IL1B 11126408 759801 The aim of this study was to investigate if TNFalpha and IFNgamma signal through mitogen activated protein kinases in isolated rat islets of Langerhans and if they potentiate [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK3 IL1B 11126408 759814 Further , TNFalpha and IFNgamma were found to synergistically increase [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK3 IL1B 11281731 764735 *Activation* of [Erk1/Erk2] by IGF1 and was studied using a phosphorylation-specific antibody . Positive_regulation MAPK3 IL1B 11399523 824262 Glucose potentiates *induced* p38 [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK3 IL1B 11399523 824269 *activates* the mitogen activated protein kinases (MAPK) [extracellular signal regulated kinase 1] and 2 ( ERK1/2 ) , p38 and c-jun NH2-terminal kinase ( JNK ) in rat islets and beta-cells . Positive_regulation MAPK3 IL1B 11399523 824272 The aim of this study was to investigate whether glucose potentiated *induced* p38 and [ERK1/2] activity in rat islets . Positive_regulation MAPK3 IL1B 11509550 848368 Although and TNF-alpha each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK3 IL1B 11557585 861405 *activated* the three [mitogen activated protein kinase] ( extracellular signal regulated kinases 1 and 2 , c-Jun NH2-terminal kinase/stress activated protein kinase , and p38 ) and the Janus kinase (JAK)-signal transducer and activator of transcription pathways . Positive_regulation MAPK3 IL1B 11698472 878054 *induced* phosphorylation and activation of p38 [MAPK] and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation MAPK3 IL1B 11698472 878100 *induced* phosphorylation of ERK and JNK as well as p38 [MAPK] in human endothelial cells . Positive_regulation MAPK3 IL1B 11728947 884811 We showed a dramatic decrease in *induced* phosphorylation of p38 [MAPK] , not extracellular signal regulated kinases 1/2 or jun NH2-terminal kinase , in rat cultured mesangial cells by FR167653 . Positive_regulation MAPK3 IL1B 11775830 766439 Role of protein tyrosine kinase in *induced* activation of [mitogen activated protein kinase] in fibroblast-like synoviocytes of rheumatoid arthritis . Positive_regulation MAPK3 IL1B 11853544 913373 Interestingly , *induced* p38 [MAPK] activity was greatly enhanced in ( alg+ ) compared with ( alg- ) cells . Positive_regulation MAPK3 IL1B 12117921 964667 mRNA expression by neutrophils was not dependent on p38 MAPK , and p38 [MAPK] was not *activated* in neutrophils incubated with A. phagocytophila . Positive_regulation MAPK3 IL1B 12131776 966863 and TNF-alpha *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK3 IL1B 12139924 969398 Regarding intracellular signaling , *activated* the p38 [mitogen activated protein kinase (MAPK)] but not the p42/p44 MAPK and , when combined with growth factors , intensified p38 activation but inhibited the growth-factor induced p42/p44 activation . Positive_regulation MAPK3 IL1B 12356282 993866 induced p44/42 [mitogen activated protein kinase (MAPK)] *activation* was inhibited by the MAPK/extracellular signal regulated protein kinase ( MEK ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK3 IL1B 12388337 1031353 CO treatment inhibited induced [ERK1/2] *activation* but did not inhibit JNK and p38 MAPK . Positive_regulation MAPK3 IL1B 12417253 1012955 Sphondin ( 50 microM ) did not affect the *induced* activations of p44/42 MAPK , p38 [MAPK] , and JNK . Positive_regulation MAPK3 IL1B 12421347 1013466 In comparison , *induced* the release of PGE2 , IL-6 and activated NF-kappaB , p38 , JNK and [ERK1/2] in mixed glial cultures , but failed to induce any of these responses in microglial cell cultures . Positive_regulation MAPK3 IL1B 12483539 1024819 Exogenous expression of either SHPS-1 mutants that lack SHP-2 binding function or a dominant negative mutant of SHP-2 markedly inhibited the *activation* of [Erk 1/2] and Akt by , whereas wild type SHPS-1 did not . Positive_regulation MAPK3 IL1B 12498315 1026317 *activated* nuclear factor-kappaB , activator protein-1 , and three classes of mitogen activated protein ( MAP ) kinases : [extracellular signal regulated kinase1/2] , c-Jun N-terminal kinase , and p38 MAP kinase . Positive_regulation MAPK3 IL1B 12500176 1026689 These data suggest that the presence of retinal holes and may *lead* to activation of HGF , [mitogen activated protein kinases (MAPK)] , c-jun and extracellular matrix remodeling , resulting in proliferative and migratory cells in the wounded retina . Positive_regulation MAPK3 IL1B 12507586 1038423 In this study we evaluated the role of epigallocatechin-3-gallate ( EGCG ) , a green tea polyphenol which mimics its anti-inflammatory effects , in modulating the *induced* activation of [MAPK] 's in human chondrocytes . Positive_regulation MAPK3 IL1B 12649265 1080069 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant MKK6 or p38beta2 MAPK inhibited induced p38 [MAPK] *activation* , COX-2 gene expression , and PGE2 release . Positive_regulation MAPK3 IL1B 12727980 1086559 P38 [MAPK] phosphorylation was *increased* by in nondecidualized ESC , whereas the IL-1 beta induced increase was suppressed in the decidualized cells . Positive_regulation MAPK3 IL1B 12727980 1086572 Treatment with 8-bromo-cAMP reduced *induced* phosphorylation of p38 [MAPK] in nondecidualized ESC . Positive_regulation MAPK3 IL1B 12727980 1086586 In contrast , treatment with H89 , a protein kinase A inhibitor , reversed a reduction in *induced* p38 [MAPK] phosphorylation in the decidualized cells . Positive_regulation MAPK3 IL1B 12727980 1086600 The altered property of decidualized cells is thought to be caused by attenuation of *induced* p38 [MAPK] phosphorylation in a way that involves the activation of the cAMP/protein kinase A pathway . Positive_regulation MAPK3 IL1B 12799018 1100966 induced release of IL-6 and *activated* NFkappaB , p38 , JNK and [ERK1/2] in mixed glial cultures , which was completely abolished in the presence of IL-1 receptor antagonist (IL-1ra) . Positive_regulation MAPK3 IL1B 12882449 1116291 NAC ( 1 mM ) also decreased the induced *activation* of p38 [MAPK] . Positive_regulation MAPK3 IL1B 12952251 1137419 Using Western-blot analysis , no effect of cAMP was found on the *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK3 IL1B 12952251 1137433 No decrease was observed in *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK3 IL1B 14563491 1154862 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Positive_regulation MAPK3 IL1B 14755545 1205624 *activated* [ERK1/2] and JNKs within 15 min of treatment . Positive_regulation MAPK3 IL1B 14755545 1205626 DPI almost completely inhibited Ang II + *stimulated* activation of [ERK1/2] , while partially inhibiting JNKs . Positive_regulation MAPK3 IL1B 14960485 1242924 These data indicate that , in normal human cytotrophoblast cells , IL-1 beta induces HIF- 1 alpha mediated VEGF secretion and that *stimulated* [ERK1/2] activation may be involved in this process . Positive_regulation MAPK3 IL1B 15039421 1251239 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of , and RIP2 dependent *activation* of NF-kappaB and p38 [MAPK] mediated by the caspase recruitment domain . Positive_regulation MAPK3 IL1B 15111866 1241241 We further demonstrated that p38 MAPK is activated by and PDGF with different kinetics and that p38 [MAPK] is *required* for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation MAPK3 IL1B 15205451 1295586 significantly *increased* the phosphorylation of [extracellular signal regulated kinase 1] ( ERK1 ) /ERK2 MAPKs and cPLA(2) and IL-1beta induced cPLA(2) phosphorylation was blocked by PD98059 . Positive_regulation MAPK3 IL1B 15208668 1281345 *induced* the activation of extracellular signal regulated kinases-1/2 and P38 [mitogen activated protein kinase (MAPK)] , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation MAPK3 IL1B 15269222 1290329 Previously , we have shown that *activates* [ERK1/2] , JNKs , and protein kinase C ( PKC ) . Positive_regulation MAPK3 IL1B 15269222 1290332 Inhibition of PKC-theta and PKC-zeta using pseudosubstrates inhibited *stimulated* activation of [ERK1/2] and JNKs and the expression and activity of MMP-2 and -9 . Positive_regulation MAPK3 IL1B 15320915 1286576 A77 1726 partially suppressed *induced* [ERK1/2] and p38 kinase activation . Positive_regulation MAPK3 IL1B 15341531 1291763 In accordance with these findings , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) , which was attenuated by U0126 , SB202190 , or SP600125 , respectively . Positive_regulation MAPK3 IL1B 15389584 1354321 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] and JNK which was attenuated by pretreatment with U0126 or SP600125 , respectively . Positive_regulation MAPK3 IL1B 15489374 1359425 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and JNK was attenuated by pretreatment with U0126 , SB-202190 , or SP-600125 , respectively . Positive_regulation MAPK3 IL1B 15659543 1375892 *stimulated* a rapid increase in the activities of early intracellular signalling molecules , [ERK1/2] and JNK . Positive_regulation MAPK3 IL1B 15749024 1379454 Recombinant mouse *induced* strong activation of [ERK1/2] , p38 , JNK and NFkappa B , and significant release of IL-6 and PGE2 , which was blocked by IL-1ra . Positive_regulation MAPK3 IL1B 15755725 1403423 The inhibitory effect of on alpha ENaC expression was *mediated* by the activation of p38 [MAPK] in both rat and human ATII cells and was independent of the activation of alpha v beta6 integrin and transforming growth factor-beta . Positive_regulation MAPK3 IL1B 16002736 1431021 *activates* both p38 and [ERK 1/2] components of the MAPK pathways . Positive_regulation MAPK3 IL1B 16033422 1436167 Intrathecal *leads* to a time dependent up-regulation of phosphorylated p38 ( p-p38 ) [MAPK] protein expression in the spinal cord 30-240 min following IL-1beta injection ( i.t. ) . Positive_regulation MAPK3 IL1B 16033422 1436181 However , pretreatment with a p38 MAPK inhibitor significantly reduced the *induced* p-p38 [MAPK] expression by 38-49 % , and nearly completely blocked the subsequent iNOS expression ( reduction by 86.6 % ) , NO production , and thermal hyperalgesia . Positive_regulation MAPK3 IL1B 16043966 1459743 Western blot analysis demonstrated that *increased* the activation of phosphorylated MEK and p38 [MAPK] in GH3 cells . Positive_regulation MAPK3 IL1B 16106045 1466633 Both and ceramide *led* to [extracellular signal regulated kinase 1/2] ( ERK1/2 ) activation as early as 15 min after treatment . Positive_regulation MAPK3 IL1B 16140882 1450807 *induced* phosphorylation of [p38-MAPK] , but not that of c-Jun-N-terminal kinase or extracellular regulated kinase , was most susceptible to inhibition by low doses of PFE , and the addition of PFE blocked the activity of p38-MAPK in a kinase activity assay . Positive_regulation MAPK3 IL1B 16141635 1454871 DHA stimulated both rapid and prolonged activation of p44/42 , but not p38 , [mitogen activated protein kinase (MAPK)] *induced* by and PMA . Positive_regulation MAPK3 IL1B 16153910 1455441 The kidney was analyzed for expression of tumor necrosis factor alpha , , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 [mitogen activated protein kinase] , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation MAPK3 IL1B 16258191 1477775 Proinflammatory cytokine *caused* a transient activation of [Erk1/2] , p38 , and JNK in immortalized human T/C28a2 chondrocytes and that was followed by enhanced COX-2 expression and PGE2 production . Positive_regulation MAPK3 IL1B 16436473 1554453 PKC-delta mediates activation of [ERK1/2] and *induction* of iNOS by in vascular smooth muscle cells . Positive_regulation MAPK3 IL1B 16436473 1554455 Recent studies have implicated mediated [ERK1/2] *activation* in the upregulation of type II nitric oxide synthase (iNOS) in VSM . Positive_regulation MAPK3 IL1B 16452991 1611741 Western blots showed that and TNF-alpha *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK3 IL1B 16528573 1549430 The aim of this study was to investigate if Gadd45b prevents *induced* beta cell [MAPK] signalling and apoptosis . Positive_regulation MAPK3 IL1B 16556731 1589303 *induced* a differential usage of cis-elements in the inducible nitric oxide synthase promoter region in the two cell-lines and an increase in [ERK1/2] activity in INS-1E cells but not in 208F cells . Positive_regulation MAPK3 IL1B 16645161 1604679 significantly *increased* the phosphorylation of p38 [MAPK] and cPLA(2) . Positive_regulation MAPK3 IL1B 16698013 1575656 JST ( 0.01-1 mg/ml ) also attenuated the expression of cyclooxygenase (COX)-2 and activation of p38 [MAPK] *induced* by and A beta ( 1-42 ) . Positive_regulation MAPK3 IL1B 16707097 1564048 *activated* the [extracellular signal regulated kinase 1/2] ( ERK1/2 ) , and this activation was also enhanced by H ( 2 ) S. Inhibition of ERK1/2 activation by the selective inhibitor U0126 inhibited IL-1beta induced NF-kappaB activation , iNOS expression , and NO production either in the absence or presence of H ( 2 ) S . Positive_regulation MAPK3 IL1B 16718462 1584911 A synthetic peptide , C3d , reported to bind NCAM , did not activate MAPK or Akt as reported in neurons but inhibited *induced* [MAPK] activity , thereby mimicking the effect of SU5402 . Positive_regulation MAPK3 IL1B 16718462 1584936 We suggest that NCAM signalling through FGFR is required for efficient IL-1beta pro-apoptotic signalling by facilitating induced [MAPK] *activation* downstream of the NF-kappaB-MAPK branching point . Positive_regulation MAPK3 IL1B 16718462 1584975 Further , these data identify a novel function of C3d as an inhibitor of NCAM induced FGFR activity and of induced [MAPK] *activation* in beta cells . Positive_regulation MAPK3 IL1B 16959849 1639700 *caused* an increase in the phosphorylation of ERK , but not [p38MAPK] or c-Jun N-terminal kinase . Positive_regulation MAPK3 IL1B 16959849 1639706 PD98059 , an Erk kinase inhibitor , significantly decreased *mediated* phosphorylation of [ERK1/2] , and attenuated the repression of baseline renin transcription in response to IL-1beta . Positive_regulation MAPK3 IL1B 16964394 1611556 Inhibitors of p38 [MAPK] and/or JNK significantly suppressed VEGF secretion both in the *presence* and absence of , while inhibitors of COX-2 , ERK1/2 , and PI3-K did not . Positive_regulation MAPK3 IL1B 16987994 1692469 *activated* [ERK1/2] , JNKs , and protein kinase C ( PKC ) , specifically PKCalpha/beta ( 1 ) , and inhibition of these cascades partially inhibited IL-1beta stimulated increases in MMP-2 . Positive_regulation MAPK3 IL1B 17208222 1695815 Thalidomide also suppressed *induced* p38 [mitogen activated protein kinase (MAPK)] activation , while a p38 MAPK inhibitor destabilized COX-2 mRNA and the cytoplasmic shuttling of HuR induced by IL-1beta . Positive_regulation MAPK3 IL1B 17311279 1719292 *stimulated* phosphorylation of p42/p44 MAPK , p38 [MAPK] , and JNK was attenuated by pretreatment with U0126 , SB202190 , SP600125 , or transfection with these dominant negative mutants of MEK , ERK , p38 and JNK , respectively . Positive_regulation MAPK3 IL1B 17390080 1716138 We have previously demonstrated that *induced* HBD-2 mRNA expression in A549 cells through activation of nuclear factor-kappaB (NF-kappaB) transcriptional factor as well as p38 [mitogen activated protein kinase (MAPK)] , c-Jun N-terminal kinase (JNK) , or phosphatidylinositol-3-kinase (PI3K) . Positive_regulation MAPK3 IL1B 17390080 1716164 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Positive_regulation MAPK3 IL1B 17390080 1716194 Triptolide inhibited *induced* [MAPK] phosphatase-1 expression at the transcriptional level and resulted in sustained phosphorylation of JNK or p38 MAPK , explaining the little effect of triptolide on IL-1beta induced phosphorylation of these kinases . Positive_regulation MAPK3 IL1B 17438131 1742778 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by TNF-alpha and , but not by ansiomycin or sorbitol . Positive_regulation MAPK3 IL1B 17559635 1753264 also *activated* extracellular signal regulated kinase , p38 [MAPK] , and c-Jun N-terminal kinase . Positive_regulation MAPK3 IL1B 17645739 1793272 Interestingly , Dex attenuated mediated *activation* of p38 [MAPK] and JNK , but not of AKT . Positive_regulation MAPK3 IL1B 17694686 1782111 IL-1beta induced NO levels and thermal hyperalgesia in rats , likely via either inhibiting the mediated p38 [MAPK] *activation* and subsequent iNOS induction , or direct attenuation of the central iNOS activity , which therefore reduces the central sensitization of inflammatory pain . Positive_regulation MAPK3 IL1B 17920534 1804192 SA981 at a concentration of 100 microM partially inhibited *induced* phosphorylation of [p38MAPK] and Akt ( 12.0 % and 36.1 % inhibition of each total amount of phosphoprotein under IL-1beta coexistence condition , respectively ) . Positive_regulation MAPK3 IL1B 17925024 1835156 *stimulated* phosphorylation of c-jun amino-terminal kinase , p38 MAPK and [extracellular signal regulated kinase-1/2] . Positive_regulation MAPK3 IL1B 17983423 1850441 Chondroitin sulfate reduced IL-1beta induced NF-kappaB nuclear translocation , but not AP-1 translocation , it decreased *induced* phosphorylation of [Erk1/2] and abrogated p38MAPK phosphorylation , but did not prevent IL-1beta induced increase in nitrite . Positive_regulation MAPK3 IL1B 18026701 1827823 Moreover , glucosamine suppressed the *induced* phosphorylation of p38 [MAPK] ( p < 0.05 at > 0.1 mM ) and the IL-1beta binding to its receptors ( p < 0.05 at 1 mM ) . Positive_regulation MAPK3 IL1B 18065201 1853665 *stimulated* activation of ERK1/2 and p38alpha [MAPK] mediates the transcriptional up-regulation of IL-6 , IL-8 and GRO-alpha in HeLa cells . Positive_regulation MAPK3 IL1B 18300858 1873452 However , the high concentration of D-glucose did increase iNOS expression in response to low concentrations of IL-1beta ( 2.5 and 5 ng/ml ) , as well as the induced *activation* of both [ERK 1/2] and NF-kappaB . Positive_regulation MAPK3 IL1B 18348730 1925317 The *activation* or inhibition of p38 [MAPK] by and/or SB203580 was analyzed by western blotting . Positive_regulation MAPK3 IL1B 18348730 1925330 *activated* the phosphorylation of p38 [MAPK] and this effect was abolished by SB203580 . Positive_regulation MAPK3 IL1B 18427719 1920725 Phosphorylated p38 ( Phos-p38 ) [mitogen activated protein kinase] was *stimulated* in SW-1353 cells by but not by HA alone . Positive_regulation MAPK3 IL1B 18556347 1965935 or leptin individually *induced* threonine/tyrosine phosphorylation of p38 [MAPK] , whereas only leptin induced tyrosine phosphorylation of JAK2 , suggesting that leptin may enhance hBD-2 production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with NF-kappaB , which is activated by IL-1beta . Positive_regulation MAPK3 IL1B 18667841 1948054 Furthermore , induced p38 [mitogen activated protein kinase (MAPK)] *activation* and upregulation of VEGF-C mRNA and protein in LLC cells was also suppressed by artemisinin or by the p38 MAPK inhibitor SB-203580 , suggesting that p38 MAPK could serve as a mediator of proinflammatory cytokine induced VEGF-C expression . Positive_regulation MAPK3 IL1B 19136710 2060849 Stimulation of CECs with also *activated* [ERK1/2] in a delayed fashion . Positive_regulation MAPK3 IL1B 19214751 2071848 *triggered* the activation of p38 and [ERK1/2] ( p44/42) MAP kinase (MAPK) signaling pathways , but WIN55,212-2 mainly inhibited p38 MAPK phosphorylation . Positive_regulation MAPK3 IL1B 19362079 2081461 *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 [mitogen activated protein (MAP) kinase] , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation MAPK3 IL1B 19375465 2106409 These compounds also suppressed *induced* [ERK1/2] activation and translocation of the NADPH oxidase subunit p67 phox from cytosol to membrane fraction . Positive_regulation MAPK3 IL1B 19522843 2136341 In chondrocytes , CS diminishes *induced* increases in p38 [mitogen activated protein kinase] ( p38MAPK ) and signal regulated kinase 1/2 ( Erk1/2 ) phosphorylation , and decreases nuclear factor-kappaB (NF-kappaB) nuclear translocation and as a consequence , reduces the formation of pro-inflammatory cytokines , IL-1beta and TNF-alpha , and pro-inflammatory enzymes , such as phospholipase A2 (PLA2) , cyclooxygenase 2 (COX-2) and nitric oxide synthase-2 (NOS-2) . Positive_regulation MAPK3 IL1B 19765281 2163525 Treatment with PIP-18 blocked *induced* p38 [MAPK] phosphorylation and resulted in attenuation of sPLA2-IIA and MMP mRNA transcription in RA SF cells . Positive_regulation MAPK3 IL1B 20060906 2218523 In the present study , we demonstrate that *caused* activation of p38 [mitogen activated protein kinase] and that the p38 inhibitor SB203580 significantly blocked the effect of IL-1beta on I ( NMDA-OUT ) in hippocampal CA1 neurons . Positive_regulation MAPK3 IL1B 20353947 2266474 In model 1 , a differentiation model , CLA *activation* of [MAPK] and induction of interleukin-8 (IL-8) , IL-6 , , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation MAPK3 IL1B 20380881 2267000 Attachment to these ECM molecules significantly increased induced *activation* of [extracellular signal regulated kinase 1/2] ( ERK1/2 ) and inhibition of RhoA and Rho kinase ( ROCK ) , coincident with loss of focal adhesions and cellular morphological changes . Positive_regulation MAPK3 IL1B 21659536 2455196 Distinct roles for Nod2 protein and autocrine in muramyl dipeptide *induced* [mitogen activated protein kinase] activation and cytokine secretion in human macrophages . Positive_regulation MAPK3 IL1B 24692548 2935247 At 1 h , this was responsible for the dexamethasone inhibition of *induced* [MAPK] activation and CXCL1 and CXCL2 mRNA expression , with a similar trend for CSF2 . Positive_regulation MAPK3 IL1B 8557638 347439 The farnesyl transferase inhibitor BZA-5B blocked activation of [ERK1/ERK2] and *induction* of NOS2 by IFN gamma and in myocytes . Positive_regulation MAPK3 IL1B 9475519 486793 Of these , *activated* only [MAPK] . Positive_regulation MAPK3 IL1B 9475519 486806 In cultured rat astrocytes , *caused* activation of [MAPK] without inducing proliferation . Positive_regulation MAPK3 IL1B 9575890 502741 Our data also indicate that both insulin and IGF-I enhance *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation and SAPK activation . Positive_regulation MAPK3 IL1B 9582321 503938 Previously we reported that *induces* activation of JNK/SAPK and p38 [MAPK] with concomitant up-regulation of cyclooxygenase (Cox)-2 expression and prostaglandin E2 ( PGE2 ) synthesis . Positive_regulation MAPK3 IL1B 9614146 509331 By Western blotting with phosphospecific antibodies and by immunocomplex kinase assay , was shown to *activate* extracellular signal regulated kinase ( ERK ) 1/2 and p38 [mitogen activated protein kinase] ( p38 ) in islets and rat insulinoma cells . Positive_regulation MAPK3 IL1B 9786861 540916 We reported previously that rapidly *activates* the c-Jun NH2-terminal/stress activated protein kinases ( JNK/SAPK ) and p38 [mitogen activated protein kinase (MAPK)] and also induces Cox-2 expression and prostaglandin E2 ( PGE2 ) production . Positive_regulation MAPK3 IL1B 9786861 540962 Overexpression of the kinase-dead form of MKK3 or MKK6 demonstrated that either of these two mutant kinases inhibited *induced* p38 [MAPK] phosphorylation and Cox-2 expression but not JNK/SAPK phosphorylation and activation . Positive_regulation MAPK3 ITGB2 12600815 1099072 IL-3 , IL-5 , and GM-CSF could enhance p38 [MAPK] and NF-kappaB activity and *induce* ICAM-1 , CD11b , and expressions on eosinophils . Positive_regulation MAPK3 ITGB2 19502238 2115871 and CD2 *synergize* for the [Erk1/2] activation in the Natural Killer ( NK ) cell immunological synapse . Positive_regulation MAPK3 ITGB2 19843511 2203203 Furthermore , beta2 integrins modulated the capacity of isolated peritoneal macrophages to take up acetylated LDL and native LDL and to phagocytose apoptotic cells , possibly via *dependent* [mitogen activated protein kinase] signalling . Positive_regulation MAPK3 ITGB2 21850266 2468777 Then , the direct interaction of on PBMCs and ICAM-1 on HK-2 cells *activated* [ERK1/2] signaling to accelerate the part of EMT of HK-2 cells induced by TGF-ß ( 1 ) . Positive_regulation MAPK3 KRT38 16630075 1552068 We have previously demonstrated that mechanical stretching induced proliferative phenotypes in human keratinocytes , as shown in increased 5-bromo-2'-deoxyuridine ( BrdU ) incorporation , [ERK1/2] activation , and K6 *induction* . Positive_regulation MAPK3 LBP 20615568 2309951 Despite activating NFkappaB , NOD1 ligand did not upregulate hepatocyte production of the acute phase proteins lipopolysaccharide binding protein , serum amyloid A , or soluble CD14 in cell culture supernatants , or upregulate mRNA expression of , serum amyloid A , C-reactive protein , or serum amyloid P . NOD2 ligand ( MDP ) did not *activate* hepatocytes when given alone , but did synergize with Toll-like receptor ligands , lipopolysaccharide (LPS) , and polyI : C to activate NFkappaB and [MAPK] . Positive_regulation MAPK3 MAP2K6 10050043 592954 In one set of experiments , we *inhibited* the activation of [MAPK] by pretreating cells with PD098059 , a specific inhibitor of ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAPK3 MAP2K6 10079106 595488 Although MKK3 , MKK4 , and all *activated* p38 [MAPk] in experimental models , only MKK3 was found to activate recombinant p38 MAPk in LPS treated neutrophils . Positive_regulation MAPK3 MAP2K6 10467256 640710 Phosphorylation of the ERKs occurred as early as 2 hr after initiating treatment , with a maximum increase occurring at approximately 24 hr. Inhibition of with the specific inhibitor , PD98059 , *blocked* the phosphorylation of [ERK1] and 2 and increased Mn ( 2+ ) toxicity . Positive_regulation MAPK3 MAP2K6 10471331 641636 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Positive_regulation MAPK3 MAP2K6 10591664 572597 The inhibitor PD 98059 ( 5 x 10 ( -6 ) mol/L ) also *inhibited* [ERK1/2] activation without affecting myogenic tone . Positive_regulation MAPK3 MAP2K6 10601295 574419 In addition , *activation* of p38 [MAPK] by constitutively active or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAPK3 MAP2K6 10713051 674404 Conversely , the inhibitors PD98059 and UO126 could *attenuate* EGF induced [mitogen activated protein kinase] activation , they do not affect the EGF induced mobility shift of caveolin-1 . Positive_regulation MAPK3 MAP2K6 10759527 683173 These results demonstrate that a plant can phosphorylate and *activate* [MAPK] , and that Tyr phosphorylation is critical for the catalytic activity of MAPK in plants . Positive_regulation MAPK3 MAP2K6 10816593 714749 The MAPK kinase selectively *stimulates* p38 [MAPK] and confers protection against stress induced apoptosis in cardiac myocytes . Positive_regulation MAPK3 MAP2K6 10891559 711217 MAP kinases (MAPK) in both G-1 and G-5 cells were indistinguishably phosphorylated , yet *dependent* [MAPK] activation was observed only in G-5 cells . Positive_regulation MAPK3 MAP2K6 11005808 752444 A inhibitor , PD98059 , *inhibited* heat shock ERK [MAPK] activation by > 75 % . Positive_regulation MAPK3 MAP2K6 11085935 750736 Similarly , *activation* of JNK by Ad-MKK7D and [p38-MAPK] by resulted in the increased expression of PGHS-2 . Positive_regulation MAPK3 MAP2K6 11234901 789766 Basal and tumor necrosis factor-alpha-inducible phosphorylation of [ERK1/2] and secretion of IL-8 and VEGF could be specifically *inhibited* by a inhibitor , U0126 . Positive_regulation MAPK3 MAP2K6 11237743 790329 The MAPK kinase ( ) inhibitor , PD98059 , *blocked* GSA stimulated [MAPK] activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Positive_regulation MAPK3 MAP2K6 11304531 826839 The *activation* of p38 [MAPK] by Galpha ( q ) and Gbetagamma was blocked by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Positive_regulation MAPK3 MAP2K6 11418104 830137 ONOO ( - ) -mediated [ERK1/2] phosphorylation was not *blocked* by inhibitors PD98059 and U0126 . Positive_regulation MAPK3 MAP2K6 11495722 846420 The inhibitor , PD98059 *attenuated* [ERK1/2] and MEK1/2 phosphorylation , as well as the migration shift of Lck induced by H ( 2 ) O ( 2 ) . Positive_regulation MAPK3 MAP2K6 11518769 851714 The inhibitors PD 98059 and U0126 *blocked* [ERK1/2] activation but did not diminish survival . Positive_regulation MAPK3 MAP2K6 11571286 875498 Taken together , these data indicate that FGF2 induced [ERK1/2] activation is entirely *mediated* by within photoreceptors , which is responsible for FGF2 stimulated photoreceptor survival . Positive_regulation MAPK3 MAP2K6 11748587 889670 The retrovirally transfected CCK ( B ) /gastrin receptor binds 125I-CCK-8 with high affinity ( Kd = 1.1 nM ) and is functionally coupled to intracellular signaling pathways including rapid and transient increase in Ca2+ fluxes , protein kinase C-dependent protein kinase D activation , and *dependent* [ERK1/2] activation . Positive_regulation MAPK3 MAP2K6 11787422 891951 Indeed the MAPK kinase ( = ) inhibitor PD98059 *inhibits* the activation of parasite [MAPK] , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Positive_regulation MAPK3 MAP2K6 11822870 909079 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of [MAPK] pathway *inhibitors* ( inhibitors PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAPK3 MAP2K6 12009309 940837 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Positive_regulation MAPK3 MAP2K6 12102690 962809 Using an epithelial cell infection model , C. pneumoniae invasion caused a rapid and sustained increase in *dependent* phosphorylation and activation of [ERK1/2] , followed by PI 3-kinase dependent phosphorylation and activation of Akt . Positive_regulation MAPK3 MAP2K6 12181740 977853 With serum deprivation , the inhibitors , PD98059 and U0126 , *inhibited* [ERK1/2] activity but did not increase apoptosis . Positive_regulation MAPK3 MAP2K6 12197778 981943 Although inhibition *prevented* S-1-P activation of [ERK1] and ERK2 and slightly but significantly inhibited basal Caco-2 proliferation , MEK inhibition did not block the S-1-P mitogenic effect . Positive_regulation MAPK3 MAP2K6 12203369 983243 Furthermore , PKC inhibitors or an inhibitor completely *suppressed* both TPA induced activation of [MAPK] and promotion of anchorage independent growth , but a cPKC-selective inhibitor partially suppressed TPA induced promotion of the growth . Positive_regulation MAPK3 MAP2K6 12225947 987909 Although an inhibitor of , PD-98059 , but not rapamycin , *blocked* ANG IV-induced phosphorylation of [ERK1/2] , both PD-98059 and rapamycin independently caused partial reduction in ANG IV-mediated cell proliferation . Positive_regulation MAPK3 MAP2K6 12356282 993872 IL-1beta induced p44/42 [mitogen activated protein kinase (MAPK)] activation was *inhibited* by the MAPK/extracellular signal regulated protein kinase ( ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK3 MAP2K6 12377770 1019992 These results suggest that MKK3 , rather than , *mediates* alphav integrin induced p38 [MAPK] activation . Positive_regulation MAPK3 MAP2K6 12450322 1018661 ANG II significantly increased aldosterone release , and this effect was inhibited by the LO inhibitor baicalein , as well as a specific p38 [MAPK] *inhibitor* , SB202190 , but not by PD098059 , a specific inhibitor of the ERK activator . Positive_regulation MAPK3 MAP2K6 12623957 1066520 Consistently , the serum- or thrombin induced phosphorylation of MEK and extracellular signal regulated kinase 1/2 ( ERK1/2 ) coincided with a *dependent* nuclear accumulation of phosphorylated [ERK1/2] and subsequent nuclear phosphorylation of the transcription factors c-myc and Elk-1 . Positive_regulation MAPK3 MAP2K6 12637559 1085506 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Positive_regulation MAPK3 MAP2K6 12659851 1073533 MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a ( MAP2K ) , which in turn *activates* a [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK3 MAP2K6 12663469 1074488 Collectively , our study indicates that a glucose induced rise in [ Ca ( 2+ ) ] ( i ) leads to cAMP induced activation of PKA that acts downstream of Ras and upstream of the MAP/Erk kinase , , to *mediate* [Erk-1/2] phosphorylation via phosphorylation activation of Raf-1 . Positive_regulation MAPK3 MAP2K6 12807428 1101823 Blockade of PI3K in combination with insulin , however , still resulted in an unaltered *dependent* phosphorylation of [ERK1/2] . Positive_regulation MAPK3 MAP2K6 12845643 1108613 Finally , both ODQ and UO126 blocked the capacity of L-arginine to restore ERK ( 1/2 ) phosphorylation in L-NAME treated cells , demonstrating that GC and are both *required* for endogenous NO-mediated [MAPK] activation . Positive_regulation MAPK3 MAP2K6 12871849 1185358 Both the effects of HNP1-3 on wound closure and ERK1/2 activation were *blocked* by specific inhibitors of the mitogen activated protein kinase kinase , whereas inhibitors of epidermal growth factor receptor tyrosine kinase , phosphatidylinositol 3-kinase , and Src did block defensin enhanced wound closure but not [ERK1/2] activation . Positive_regulation MAPK3 MAP2K6 12882762 1150068 HBEGF treatment stimulates *dependent* [ERK1/2] phosphorylation and leads to nuclear accumulation of Fra-1 . Positive_regulation MAPK3 MAP2K6 12899940 1118666 In addition , PD98059 , a inhibitor , *prevented* overall tyrosine phosphorylation and phosphorylation of [ERK1/2] . Positive_regulation MAPK3 MAP2K6 14988413 1236697 Inhibition of either cAMP dependent protein kinase (PKA) or completely *blocked* [ERK1/2] activation by glucagon . Positive_regulation MAPK3 MAP2K6 14992744 1215724 In the HCC cells examined , inhibitors *blocked* [ERK1] ,2 phosphorylation without a change in total ERK expression . Positive_regulation MAPK3 MAP2K6 15104236 1240331 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( ) inhibitor , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAPK3 MAP2K6 15172888 1288408 Importantly , the presence of inhibitors only at the time of the transport assay markedly *impaired* both insulin stimulated glucose uptake and [MAPK] signaling . Positive_regulation MAPK3 MAP2K6 15172888 1288504 Conversely , removal of inhibitors before the transport assay *restored* glucose uptake and [MAPK] signaling . Positive_regulation MAPK3 MAP2K6 15226277 1273989 An Src kinase inhibitor , pp2 , and inhibitor , PD98059 , *blocked* the [ERK1/2] phosphorylation and eNOS expression . Positive_regulation MAPK3 MAP2K6 15231676 1269271 Thus , activation of FGF-1- and HRGbeta1-specific signaling causes *dependent* prolonged activation of [ERK1/2] , which is incompletely susceptible to known MEK inhibitors . Positive_regulation MAPK3 MAP2K6 15304546 1322531 Furthermore , *activation* of [ERK/MAPK] by the coexpression of constitutively active predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAPK3 MAP2K6 15365248 1294589 Treatment of keratinocytes with PD98059 , inhibitor , and SB20358 , p38 [MAPK] *inhibitor* , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAPK3 MAP2K6 15570612 1355585 Although the inhibitors *suppressed* [MAPK] phosphorylation in both OA- and AICAR treated oocytes , meiotic resumption was not causally linked to MAPK phosphorylation in either group . Positive_regulation MAPK3 MAP2K6 15647286 1381481 In vitro analyses offer mechanistic support for the role of mechanical stimuli in promoting a dependent *activation* of [ERK1/2] . Positive_regulation MAPK3 MAP2K6 15757891 1417026 We also report a prolonged dependent *activation* of [ERK1/2] and increased c-FOS expression induced by TRAIL in this system . Positive_regulation MAPK3 MAP2K6 15867183 1404245 In cultured cardiac myocytes , specific *activation* of stress activated [mitogen activated protein kinase] , p38 , by upstream activator led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAPK3 MAP2K6 15879307 1411360 Conversely , constitutively active *induced* p38 [MAPK] activation that recapitulated the effects of polyphenols by inducing ERalpha phosphorylation and downstream activation of Akt , and eNOS . Positive_regulation MAPK3 MAP2K6 16105664 1448354 The inhibitors , PD98059 and U0126 , *blocked* LTB4 stimulated [ERK1/2] activation and cell proliferation . Positive_regulation MAPK3 MAP2K6 16157033 1455781 SB203580 , a [P38MAPK] *inhibitor* , and U0126 , a inhibitor , both completely blocked ADM mediated responses in MsC . Positive_regulation MAPK3 MAP2K6 16176063 1457757 The LPA induced phosphorylation of [ERK 1/2] and CREB was *blocked* by inhibition of PI3K , PKC and , but that of Akt was only inhibited by wortmannin , the PI3K inhibitor . Positive_regulation MAPK3 MAP2K6 16569214 1574697 Ca2+ mediated [ERK1/2] activation in NO* producing cells could be *restored* by exogenous expression of constitutively active 1 . Positive_regulation MAPK3 MAP2K6 16892039 1597110 *dependent* [Erk1] and Erk2 ( hereafter referred to as Erk1/2 ) signaling is identified as a downstream target of M. leprae induced ErbB2 activation that mediates demyelination . Positive_regulation MAPK3 MAP2K6 16914115 1608451 Inhibition of *prevented* SNAP stimulated [ERK1/2] activation and TRX-1 nuclear migration . Positive_regulation MAPK3 MAP2K6 17416211 1777901 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK3 MAP2K6 17596563 1792505 The inhibitor , U0126 , and the PKA inhibitors , H89 and cAMP dependent protein kinase peptide inhibitor ( PKI ) , completely *inhibited* [MAPK3/1] activation by either ADCYAP1 or CPT-cAMP . Positive_regulation MAPK3 MAP2K6 17728396 1817141 Taken together , our studies identify novel links between the physiological state of the cell , the *activation* of -- > [ERK1/2] signaling , and the nucleocytoplasmic distribution of AMPK . Positive_regulation MAPK3 MAP2K6 17728397 1817192 Ouabain induced activation of [ERK1/2] was *prevented* by Src , EGFR , and inhibitors , but not by PI3K inhibitors . Positive_regulation MAPK3 MAP2K6 17958324 1814909 It was confirmed that the activation of [ERK1/2] was *reduced* by inhibitor PD98059 . Positive_regulation MAPK3 MAP2K6 18006496 1851673 Previous work with the angiotensin AT1a receptor has shown that G ( q/11 ) activation leads to a rapid and transient rise in ERK1/2 activity , whereas beta-arrestin binding supports sustained [ERK1/2] *activation* by scaffolding a Raf . . ERK complex associated with the internalized receptor . Positive_regulation MAPK3 MAP2K6 18212269 1870863 A 1/2 inhibitor *inhibited* both renin and prorenin induced [ERK 1/2] phosphorylation . Positive_regulation MAPK3 MAP2K6 18390828 1913324 Selective inhibitors ( U0126 and PD-98059 ) *blocked* both IL-8/CXCL8 release and [ERK1/2] phosphorylation . Positive_regulation MAPK3 MAP2K6 18401006 1925852 CyaA enhanced LPS induced phosphorylation of p38 [MAPK] and ERK in DC , and inhibitors of p38 MAPK , , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation MAPK3 MAP2K6 18463290 1910078 Using 293A cells and in vitro experiments , we detail the formation of a ternary complex of , *activation* of MEK1 and [ERK1/2] kinase activities by hBVR , and phosphorylation of hBVR by ERK1/2 . Positive_regulation MAPK3 MAP2K6 18544565 1945814 *Enhancement* of [ERK1/2] signaling by constitutively active 1/2 ( MKK1/2-CA ) increased Rad51 protein levels and protein stability in gefitinib and cisplatin or MMC cotreated cells . Positive_regulation MAPK3 MAP2K6 18754769 1968457 ( MKK) 3 and 6 are the main p38 [mitogen activated protein kinase] *activators* in mammals . Positive_regulation MAPK3 MAP2K6 18771907 1962702 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a inhibitor , and SB203580 , an *inhibitor* of p38 [mitogen activated protein (MAP) kinase] , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAPK3 MAP2K6 19060905 2024020 [ERK1/2] is *activated* by ( MEK1 ) and MEK2 ( commonly referred to as MEK1/2 ) -dependent phosphorylation in the TEY motif of the activation loop , but how ERK1/2 is targeted toward specific substrates is not well understood . Positive_regulation MAPK3 MAP2K6 19835659 2154928 By phosphorylating at Ser and Thr residues , *activates* [ERK1/2] , which then phosphorylates cytoplasmic and nuclear substrates . Positive_regulation MAPK3 MAP2K6 19835659 2154944 To further investigate the regulation of ERK1/2 signalling , we examined the expression and activation of MEKs , the interaction of MEK with ERKs , *mediated* activation of [ERK1/2] , and ERK1/2 mediated activation of nuclear substrate Elk-1 in the prefrontal cortex and hippocampus of suicide subjects . Positive_regulation MAPK3 MAP2K6 19914607 2197735 While basal activity was *required* for both s/s- and PMA induced [ERK1/2] activation , MEK activity increased only in response to PMA . Positive_regulation MAPK3 MAP2K6 21426904 2432241 Inhibition of with U0126 also *blocked* bradykinin induced [ERK1/2] phosphorylation . Positive_regulation MAPK3 MAP2K6 21440529 2417054 The specific inhibitor , U0126 , significantly *blocks* EGF and TGF-a mediated [ERK1/2] activation and subsequent MMP1 induction in SK-BR3 cells . Positive_regulation MAPK3 MAP2K6 21557297 2464120 Pharmacologic inhibition of EGFR , , and PI3K kinase activity in SCC10A *reduced* phosphorylated levels of [ERK-1/2] and AKT , production of MMP-9 and sE-cad , cell migration and invasion , and expressional changes of EMT markers ( E-cadherin and N-cadherin ) induced by EGF , indicating that EGFR activation promotes cell migration and invasion via ERK-1/2 and PI3K regulated MMP-9/E-cadherin signaling pathways . Positive_regulation MAPK3 MAP2K6 21624348 2446125 The inhibitor , PD0325901 , *inhibits* proliferation and [ERK1/2] phosphorylation while also suppressing the expression of Cyclin D1 . Positive_regulation MAPK3 MAP2K6 21892182 2491665 Further , we show that *activation* of p38 [MAPK] by expression of constitutively active ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAPK3 MAP2K6 22164285 2517913 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of and marked *activation* of p38 [MAPK] . Positive_regulation MAPK3 MAP2K6 22674052 2719239 Besides , expression of phosphorylated-AKT and [phosphorylated-ERK1/2] in fluoxetine treated NSCs was effectively *blocked* ( P < 0.05 ) by both PI3-K inhibitor ( LY294002 ) and inhibitor ( PD98059 ) . Positive_regulation MAPK3 MAP2K6 22785235 2691915 TRH induced CRE promoter was inhibited by [mitogen activated protein kinase/ERK] kinase ( MEK ) inhibitor and was *increased* by overexpression of . Positive_regulation MAPK3 MAP2K6 23096919 2710682 Constitutive activation of the 1 ( CaMEK ) can *promote* [ERK1/2] expression , which is thereby expected to exert protective action on the heart against ischemia-reperfusion injury . Positive_regulation MAPK3 MAP2K6 23293787 2712021 ET-1 via the ETB receptor significantly increased [ERK1/2] phosphorylation , and was *prevented* by inhibition . Positive_regulation MAPK3 MAP2K6 23797152 2838773 In turn , Fyn kinase activation promotes *mediated* transient phosphorylation of [ERK1/2] . Positive_regulation MAPK3 MAP2K6 23919615 2826247 Treatment of quiescent HIEC with serum *induced* [ERK1/2] activation , E2F4 phosphorylation , E2F4 nuclear translocation and G1/S phase transition while inhibition of signaling by U0126 prevented these events . Positive_regulation MAPK3 MAP2K6 7541116 310281 then *activates* p42mapk and ( at least in mammals ) [p44mapk] , members of the mitogen activated protein (MAP) kinase family . Positive_regulation MAPK3 MAP2K6 7644477 318686 Inhibition of by PD 098059 *prevented* activation of [MAPK] and subsequent phosphorylation of MAPK substrates both in vitro and in intact cells . Positive_regulation MAPK3 MAP2K6 7822248 285619 ( MKK ) phosphorylates and *activates* [mitogen activated protein kinase (MAPK)] in response to stimulation of various eukaryotic signaling pathways . Positive_regulation MAPK3 MAP2K6 7889302 289463 2. Both nucleotides stimulate phosphorylation and *activation* of [mitogen activated protein kinase] and a biphasic phosphorylation of the up-stream . Positive_regulation MAPK3 MAP2K6 8180183 256263 This stimulation of the activator was temporally *followed* by increased activities of MEK and [MAPK] . Positive_regulation MAPK3 MAP2K6 8226933 235434 *Activation* of extracellular signal regulated kinase ( ERK ) or [mitogen activated protein kinase] by ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAPK3 MAP2K6 8394352 228264 We show that a similar activity phosphorylates and *activates* [MAPK] in both growth factor stimulated ( epidermal growth factor and thrombin ) and oncogene ( gip2 , v-src , and v-raf ) -transfected cells . Positive_regulation MAPK3 MAP2K6 8550616 346694 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Positive_regulation MAPK3 MAP2K6 8662760 367283 Stimulation of transfected cells with fMLP resulted in the time- and dose dependent increase in tyrosine phosphorylation and activation of [ERK1] and ERK2 and the *activation* of , the MAP kinase/ERK kinase . Positive_regulation MAPK3 MAP2K6 8663100 368181 The [MAPK] and NHE activities induced by PMA were *inhibited* by staurosporine , a potent inhibitor for protein kinase C ( PKC ) , and by MAPK kinase ( ) inhibitor , PD98059 , but were not affected by the tyrosine kinase inhibitor genistein . Positive_regulation MAPK3 MAP2K6 8663100 368279 In contrast , both AVP induced [MAPK] and NHE activities were *inhibited* by genistein and inhibitor but were not affected by staurosporine . Positive_regulation MAPK3 MAP2K6 8816498 384318 *activates* [mitogen activated protein kinase (MAPK)] , which phosphorylates other kinases as well as transcription factors . Positive_regulation MAPK3 MAP2K6 9135064 427635 In addition to *dependent* [MAPK] activation , we provide evidence for MEK independent regulation of the MAPKs . Positive_regulation MAPK3 MAP2K6 9166761 432483 The first step in [MAPK] *activation* by must be the formation of a MEK x MAPK enzyme-substrate complex , followed by phosphorylation producing monophosphorylated MAPK ( pMAPK ) . Positive_regulation MAPK3 MAP2K6 9275096 450654 We show here , that in the human neuroblastoma cell line SK-N-SH , the membrane impermeable conjugated 17beta-estradiol ( E2BSA ) activates ( MAPKK or MEK ) and *induces* the phosphorylation and activation of both [ERK-1] and ERK-2 ( mitogen activated protein kinase or MAPK ) . Positive_regulation MAPK3 MAP2K6 9626658 511919 These results indicate that *mediates* the IGF-I/insulin induced p42/ p44 [MAPK] activation . Positive_regulation MAPK3 MAP2K6 9804770 544429 Furthermore , NE stimulated the expression and secretion of basic fibroblast growth factor (bFGF) , which further promoted the cell survival via *dependent* activation of [Erk1/2] . Positive_regulation MAPK3 MAP2K6 9813041 546118 The inhibitor *blocked* GH-stimulated activation of MEK , phosphorylation of [ERK1/ERK2] , and MAP kinase activity in 3T3-F442A cells . Positive_regulation MAPK3 MAP2K6 9864179 582752 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of ERK , but not p38 [MAPK] , induced by G-CSF , GM-CSF , or TNF . Positive_regulation MAPK3 MMP28 15143154 1273137 Agonist mediated activation in C9 cells *led* to shedding of heparin binding EGF (HB-EGF) and stimulation of [ERK1/2] phosphorylation . Positive_regulation MAPK3 MMP28 15277330 1277148 inhibitors ( batimastat and Ro28-2653 ) and the blocking antibodies anti-MMP-2 and anti-membrane type 1-MMP *inhibited* the oxLDL induced sphingomyelin/ceramide pathway activation and subsequent activation of [ERK1/2] and DNA synthesis but did not inhibit the oxLDL induced epidermal growth factor receptor and platelet derived growth factor receptor activation . Positive_regulation MAPK3 MMP28 16336626 1503765 Phe induced phosphorylation of the EGF-R , and subsequently of Shc and [ERK1/2] , was *attenuated* by inhibition of or HB-EGF with the selective inhibitor , CRM197 , or by a neutralizing antibody . Positive_regulation MAPK3 MMP28 16848631 1588375 However , inhibition of the transient Erk1/2 activity with a specific mitogen activated protein kinase kinase 1 ( MEK-1 ) inhibitor PD 98059 prevented subsequent hypoxia induced proliferation at 18 h. Interestingly , inhibition of general activity , using either doxycycline or GM 6001 , *prevented* both transient [Erk1/2] activity and subsequent proliferation in response to hypoxia . Positive_regulation MAPK3 MMP28 16877348 1593682 Similarly , stretching BSMCs in vitro induced increases in [ERK1/2] activation and ERK1/2 dependent proliferation under discrete mechanical conditions , and distension conditioned medium itself *induced* dependent ERK1/2 activation in BSMCs . Positive_regulation MAPK3 MMP28 17907155 1812601 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not *prevent* HGF induced [ERK-1/2] phosphorylation and NF-kappaB activity , but significantly restored HGF inhibited collagen and CTGF accumulation . Positive_regulation MAPK3 MMP7 15143154 1273152 Agonist mediated activation in C9 cells *led* to shedding of heparin binding EGF (HB-EGF) and stimulation of [ERK1/2] phosphorylation . Positive_regulation MAPK3 MMP7 15277330 1277163 inhibitors ( batimastat and Ro28-2653 ) and the blocking antibodies anti-MMP-2 and anti-membrane type 1-MMP *inhibited* the oxLDL induced sphingomyelin/ceramide pathway activation and subsequent activation of [ERK1/2] and DNA synthesis but did not inhibit the oxLDL induced epidermal growth factor receptor and platelet derived growth factor receptor activation . Positive_regulation MAPK3 MMP7 16336626 1503781 Phe induced phosphorylation of the EGF-R , and subsequently of Shc and [ERK1/2] , was *attenuated* by inhibition of or HB-EGF with the selective inhibitor , CRM197 , or by a neutralizing antibody . Positive_regulation MAPK3 MMP7 16848631 1588325 and epidermal growth factor receptor mediate hypoxia *induced* [extracellular signal regulated kinase 1/2] mitogen activated protein kinase activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MAPK3 MMP7 16848631 1588390 However , inhibition of the transient Erk1/2 activity with a specific mitogen activated protein kinase kinase 1 ( MEK-1 ) inhibitor PD 98059 prevented subsequent hypoxia induced proliferation at 18 h. Interestingly , inhibition of general activity , using either doxycycline or GM 6001 , *prevented* both transient [Erk1/2] activity and subsequent proliferation in response to hypoxia . Positive_regulation MAPK3 MMP7 16877348 1593697 Similarly , stretching BSMCs in vitro induced increases in ERK1/2 activation and ERK1/2 dependent proliferation under discrete mechanical conditions , and distension conditioned medium itself induced *dependent* [ERK1/2] activation in BSMCs . Positive_regulation MAPK3 MMP7 17907155 1812617 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not *prevent* HGF induced [ERK-1/2] phosphorylation and NF-kappaB activity , but significantly restored HGF inhibited collagen and CTGF accumulation . Positive_regulation MAPK3 MMP7 21999204 2547387 Mesothelin enhances invasion of ovarian cancer by *inducing* through [MAPK/ERK] and JNK pathways . Positive_regulation MAPK3 MUC16 11481474 843894 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a [mitogen activated protein kinase] ( Erk 1/2 ) , and *activation* of transcription . Positive_regulation MAPK3 MYH16 18650426 1960266 A thrombin-inducible expression of smooth muscle-specific alpha-actin and *requires* transactivation of the epidermal growth factor (EGF) receptor and a biphasic activation of [ERK1/2] . Positive_regulation MAPK3 MYH3 18650426 1960274 A thrombin-inducible expression of smooth muscle-specific alpha-actin and *requires* transactivation of the epidermal growth factor (EGF) receptor and a biphasic activation of [ERK1/2] . Positive_regulation MAPK3 NEDD9 20855887 2346817 Both primary intestinal epithelial cells from TRIF-KO mice and TRIF silenced NCM460 cells significantly reduced flagellin induced NF?B ( and p65 ) , JNK1/2 , and [ERK1/2] *activation* compared with control cells . Positive_regulation MAPK3 NT5E 18980528 1983326 *increased* the levels of phosphorylated [ERK1/2] . Positive_regulation MAPK3 OXTR 12810550 1102580 [Extracellular signal regulated kinase 1/2] *activation* by myometrial involves Galpha ( q ) Gbetagamma and epidermal growth factor receptor tyrosine kinase activation . Positive_regulation MAPK3 OXTR 21963428 2522101 We found that mediated [ERK1/2] *activation* was attenuated significantly when cells were pretreated with the ß ( 2 ) AR agonist isoproterenol or two antagonists , propranolol or timolol . Positive_regulation MAPK3 OXTR 21963428 2522102 In contrast , pretreatment of cells with a third ß ( 2 ) AR antagonist , atenolol resulted in an increase in mediated [ERK1/2] *activation* . Positive_regulation MAPK3 PECAM1 16594905 1544552 When endothelial cells are stimulated by fluid shear stress , is tyrosine phosphorylated and *activates* the [extracellular signal regulated kinase 1] and 2 ( ERK1/2 ) signalling cascade . Positive_regulation MAPK3 PECAM1 18029285 1866924 In contrast , expression of Delta15 in PECAM-1-/- bEND cells *had* minimal effects on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Positive_regulation MAPK3 PGC 22105890 2599544 Our studies also revealed that overexpression of in cardiomyocytes *inhibited* basal and T3-induced p38 [MAPK] phosphorylation . Positive_regulation MAPK3 PGC 22767158 2676363 hesperetin activates PI-3 K , PKA , PKC , [ERK1] and CREB , and it *induces* PI-3 K , PKA , and seladin-1 via both ER and TrkA ; Positive_regulation MAPK3 PIGR 20450283 2257150 Induction of expression in HT-29 cells *required* NF-kappaB signaling but not [MAPK] signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation MAPK3 PLAT 15231724 1289414 The sphingomyelin/ceramide pathway is involved in [ERK1/2] phosphorylation , cell proliferation , and uPAR overexpression *induced* by . Positive_regulation MAPK3 PLAT 19436314 2107041 cerebrospinal fluid and brain parenchymal ERK [MAPK] was elevated by H/I and this upregulation was *potentiated* by , but blunted by RBC-tPA . Positive_regulation MAPK3 PLAT 21037505 2499497 Red blood blocked c-Jun-N-terminal kinase but *potentiated* p38 [mitogen activated protein kinase] upregulation after photothrombotic injury . Positive_regulation MAPK3 PLAT 24129569 2875077 We demonstrate that enzymatically active and inactive ( EI-tPA ) *activate* [ERK1/2] in a biphasic manner . Positive_regulation MAPK3 PLAT 24129569 2875078 In the second phase , [ERK1/2] is *activated* by independently of LRP1 . Positive_regulation MAPK3 PLAT 24129569 2875079 Rapid [ERK1/2] activation in *response* to and activated a2-macroglobulin ( a2M* ) required the NMDA receptor and Trk receptors , which assemble with LRP1 into a single pathway . Positive_regulation MAPK3 PLAU 10766865 684607 surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha [mitogen activated protein kinase] activity . Positive_regulation MAPK3 PLAU 15031204 1257171 In HeLa cells the dominant negative form of JNK interferes with the p42/p44 [MAPK] *activation* of the . Positive_regulation MAPK3 PLAU 15874933 1405700 Activation of the [mitogen activated protein kinases (MAPK)] , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Positive_regulation MAPK3 PLAU 15874933 1405733 Although uPA induced phosphorylation of both ERK1/2 and p38 MAPK was blocked by Galphai inhibition , inhibition of PI3K and Ras decreased the *induced* phosphorylation of ERK1/2 but not p38 [MAPK] . Positive_regulation MAPK3 PLAU 18656457 1960566 Exogenous administered at 4 h post H/I further *stimulated* ERK [MAPK] phosphorylation , which was blocked by RAP . Positive_regulation MAPK3 PLAU 19735728 2147177 We report that , as well as its catalytically inactive N-amino fragment ATF , *triggers* the sequential activation of MMP-2 , NSMase-2 and [ERK1/2] in ECV304 cells that are required for uPA induced ECV304 proliferation , as assessed by the inhibitory effect of Marimastat ( a MMP inhibitor ) , MMP-2-specific siRNA , MMP-2 defect , and NSMase-specific siRNA . Positive_regulation MAPK3 PLAU 9525964 495934 Binding of to its receptor in MCF-7 cells *activates* [extracellular signal regulated kinase 1] and 2 which is required for increased cellular motility . Positive_regulation MAPK3 PLAU 9660790 517501 The receptor *mediates* tyrosine phosphorylation of focal adhesion proteins and activation of [mitogen activated protein kinase] in cultured endothelial cells . Positive_regulation MAPK3 PLAU 9660790 517514 The induced *activation* of [MAPK] was completely inhibited by genistein , but not by 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo [ 3 , 4-d ] pyrimidine , a specific inhibitor of Src family kinases . Positive_regulation MAPK3 PODXL 17616675 1769275 expression also *led* to an increase in [mitogen activated protein kinase (MAPK)] and phosphatidylinositol 3-kinase (PI3K) activity . Positive_regulation MAPK3 PODXL 17616675 1769322 These findings suggest that leads to increased in vitro migration and invasion , increased MMP expression , and *increased* activation of [MAPK] and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MAPK3 PTGER2 19233324 2072061 Further , PGE ( 2 ) , EP2A and EP4A did not increase BMP2/4 mRNA levels in RC cells , and *induced* phosphorylation of p38 [MAPK] was not eliminated by Noggin . Positive_regulation MAPK3 RGS2 16685212 1560098 Reduced expression of ( RGS2 ) in hypertensive patients *increases* calcium mobilization and [ERK1/2] phosphorylation induced by angiotensin II . Positive_regulation MAPK3 RGS2 18398336 1893707 Silencing in BS/GS patients *increased* Ang II-induced Cai2+ release and [ERK 1/2] phosphorylation in silenced cells compared with not silenced cells [ 59.3 +/- 10.8 ( peak-basal ) vs. 40.5 +/- 14.1 nmol/l , P = 0.017 and 0.84 +/- 0.06 vs. 0.64 +/- 0.08 nmol/l , P < 0.03 , respectively ] , whereas they were not different compared with controls ( 60.1 +/- 4.3 and 0.91 +/- 0.03 nmol/l ) . Positive_regulation MAPK3 S100B 17564756 1804575 By contrast , in FL-RAGE cells but not in Delta-RAGE cells and AGEs *activate* [p42/44 MAPK] , augment cyclin D(1)/cdk4 protein and RNA levels and the transition into the S-phase . Positive_regulation MAPK3 S100B 19910580 2189354 These results suggest that interaction of RAGE and its ligand after myocardial infarction may play a role in myocyte apoptosis by *activating* [ERK1/2] and p53 signaling . Positive_regulation MAPK3 S100B 20672023 2298627 induces apoptosis by an extracellular mechanism via interaction with the receptor for advanced glycation end products and *activating* [ERK1/2] and p53 signaling . Positive_regulation MAPK3 SLC38A3 15331357 1288027 In contrast , *stimulated* [MAPK] activation was blocked by > 80 % by dominant negative Ras but not by dominant negative Rho and Cdc42 . Positive_regulation MAPK3 SNCAIP 12639553 1068705 In addition , [MAPK] was *activated* by through Edg-1 , Sph-1-P receptor . Positive_regulation MAPK3 SPHK1 12441135 1017080 While both ERK and Akt have been implicated in MCF-7 cell growth , *stimulated* [ERK1/2] but had no effect on Akt . Positive_regulation MAPK3 SPHK1 15863357 1401134 The overexpression of wild-type , but not dominant negative SPHK1 , *resulted* in high basal levels of [ERK1/2] phosphorylation and stimulated granulocytic differentiation in HL60 cells . Positive_regulation MAPK3 SPHK1 16278291 1502530 Additional data revealed a specific role of dhS1P , and not S1P , as a mediator of *dependent* activation of [ERK1/2] and up-regulation of MMP1 . Positive_regulation MAPK3 SPHK1 16622018 1551520 Macrophage 's proinflammatory response to a mycobacterial infection is dependent on *mediated* activation of phosphatidylinositol phospholipase C , protein kinase C , [ERK1/2] , and phosphatidylinositol 3-kinase . Positive_regulation MAPK3 SPHK1 18602364 1941508 As a result , inhibition of by SKI *blocked* phosphorylation of p38 [MAPK] , showing that SPHK activation by IL-18 is an upstream signal of p38 MAPK activation . Positive_regulation MAPK3 SPHK1 21803151 2484743 activation *requires* PKC and MAPK [ERK1/2] . Positive_regulation MAPK3 SPHK1 22684547 2705931 *increased* the constitutive expression of [extracellular signal regulated kinase1/2] ( ERK1/2 ) but reduced the constitutive expression of p38 mitogen activated protein kinase (MAPK) . Positive_regulation MAPK3 STK39 17237610 1690301 The phosphorylation of cytoplasmic p38 [MAPK] in Akata cells was *reduced* by the inhibitor , 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperazine ( H7 ) . Positive_regulation MAPK3 TCN1 18959821 1982902 ( C8orf4 ) is *involved* in [ERK1/2] pathway regulated G(1)- to S-phase transition . Positive_regulation MAPK3 TFPI2 18703135 1961391 Overexpression of PP2A or partially *prevented* Cd-induced activation of [Erk1/2] and JNK , as well as cell death . Positive_regulation MAPK3 TFPI2 22298641 2580286 Overexpression of PP2A or partially *prevented* curcumin induced activation of JNK and [Erk1/2] phosphorylation as well as cell death . Positive_regulation MAPK3 TGM2 12401808 1036049 Further , by using stable SH-SY5Y cell lines ( overexpressing wild-type , C277S mutant , and antisense TGase ) , we demonstrate that activity is *required* for activation of RhoA , [ERK1/2] , JNK1 , and p38gamma MAP kinases . Positive_regulation MAPK3 TLR7 16424221 1515585 MKP-1-deficient macrophages also show enhanced constitutive and *induced* activation of p38 [MAPK] . Positive_regulation MAPK3 TLR7 18287072 1872548 However , when coupled with Sema6D , a ligand for Plexin-A1 , limited *resulted* in PDC-TREM mediated DAP12 dependent phosphorylation of phosphoinositide 3-kinase (PI3K) and [extracellular regulated kinase (Erk) 1/2] at 6-9 h , and IFN-alpha was produced . Positive_regulation MAPK3 TLR7 23979601 2850665 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Positive_regulation MAPK3 TLR7 24259503 2892740 stimulation of TRAF5-deficient B cells did not affect cell survival , proliferation , or NF-?B activation but *resulted* in markedly enhanced phosphorylation of the MAPKs [ERK1/2] and JNK . Positive_regulation MAPK3 TLR7 24404585 2884125 Together , our finding shows that in addition to the *mediated* TPL2 activation of [ERK1/ERK2] , an additional pathway contributing to ERK1/ERK2 activation is triggered by infection of CF AECs : the EGFR signaling pathway . Positive_regulation MAPK3 TLR7 24879442 2941016 GIT2 terminates *induced* NF-?B and [MAPK] signaling by recruiting the deubiquitinating enzyme Cylindromatosis to inhibit the ubiquitination of TRAF6 . Positive_regulation MAPK3 TMEM100 17711860 1801215 We show that betaKlotho , a single-pass highly expressed in liver and fat , *induced* [ERK1/2] phosphorylation in response to FGF19 treatment and significantly increased the interactions between FGF19 and FGFR4 . Positive_regulation MAPK3 TMEM156 17711860 1801233 We show that betaKlotho , a single-pass highly expressed in liver and fat , *induced* [ERK1/2] phosphorylation in response to FGF19 treatment and significantly increased the interactions between FGF19 and FGFR4 . Positive_regulation MAPK3 TMEM211 17711860 1801313 We show that betaKlotho , a single-pass highly expressed in liver and fat , *induced* [ERK1/2] phosphorylation in response to FGF19 treatment and significantly increased the interactions between FGF19 and FGFR4 . Positive_regulation MAPK3 TMEM213 17711860 1801250 We show that betaKlotho , a single-pass highly expressed in liver and fat , *induced* [ERK1/2] phosphorylation in response to FGF19 treatment and significantly increased the interactions between FGF19 and FGFR4 . Positive_regulation MAPK3 TNF 10092829 600977 Implication of TNF receptor-I mediated extracellular signal regulated kinases 1 and 2 ( ERK1/2 ) activation in growth of AIDS associated Kaposi 's sarcoma cells : a possible role of a novel death domain protein MADD in *induced* [ERK1/2] activation in Kaposi 's sarcoma cells . Positive_regulation MAPK3 TNF 10092829 600978 We found that extracellular signal regulated kinases 1 and 2 ( [ERK1/2] ) in KS cells were significantly *activated* by through tyrosine/threonine phosphorylation . Positive_regulation MAPK3 TNF 10092829 600981 Using neutralizing anti-TNFR-I and TNFR-II mAbs , we have now obtained evidence that *induced* KS cell growth and [ERK1/2] activation are mediated exclusively by TNFR-I , not by TNFR-II . Positive_regulation MAPK3 TNF 10331740 614759 However , inhibition of *induced* [ERK1/2] activity by the MAP/ERK kinase 1 inhibitor PD 98059 resulted in 60 % inhibition of cell growth in TNF alpha treated UCI 101 cells . Positive_regulation MAPK3 TNF 10331740 614760 Thus , the inhibition of *induced* [ERK1/2] activity was associated with induction of apoptosis in the TNF alpha-resistant cell line UCI 101 . Positive_regulation MAPK3 TNF 10331740 614761 Inhibition of *induced* [ERK1/2] activity was accompanied by a subsequent transient increase in TNF alpha induced JNK1 activity . Positive_regulation MAPK3 TNF 10504489 648984 Pretreatment with SB203580 ( 10 microM ) had no effect on basal or TNF-alpha stimulated phosphorylation of p38 MAPK but completely abolished *stimulated* p38 [MAPK] activity . Positive_regulation MAPK3 TNF 10521481 653114 The study presented here shows that autoregulation of gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 [mitogen activated protein (MAP) kinase] activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation MAPK3 TNF 10570180 568162 Furthermore , LPS , UV irradiation , and *caused* activation of p38 [MAPK] whereas IFN-gamma did not . Positive_regulation MAPK3 TNF 10601128 574209 alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation MAPK3 TNF 10625622 658604 The phosphorylation of [ERK1/2] was rapidly *induced* by TRAP and bFGF but not by . Positive_regulation MAPK3 TNF 10640438 577507 IL-1 beta and also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK3 TNF 10669634 665809 In this study , we show that *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation MAPK3 TNF 10753884 682344 Moreover , *stimulated* both the NF-kappaB and [mitogen activated protein (MAP) kinase] ( extracellular signal regulated kinase , c-Jun NH ( 2 ) -terminal kinase , and p38 MAP kinase ) signaling pathways in astrocytes . Positive_regulation MAPK3 TNF 10783388 707851 *dependent* p38 [MAPK] activation was detected in both Mo7e and Hut-78 cells and was blocked by the p38 MAPK inhibitor , SB203580 . Positive_regulation MAPK3 TNF 10783388 707904 SB203580 did not affect TNF-alpha signaled nuclear translocation and DNA binding activity of NF-kappaB , and inhibition of NF-kappaB function did not affect induced p38 [MAPK] *activation* , indicating that these events are not dependent on each other . Positive_regulation MAPK3 TNF 10864897 705729 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK3 TNF 10864897 705781 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by and IL-1beta . Positive_regulation MAPK3 TNF 10913368 716281 *Activation* of [ERK1/2] and cPLA(2) by the p55 receptor occurs independently of FAN . Positive_regulation MAPK3 TNF 11067939 747585 CPPD crystals were observed to *induce* a robust and transient activation of [ERK1] , ERK2 , and Akt , whereas produced only a modest and delayed activation of Akt . Positive_regulation MAPK3 TNF 11095634 755301 rapidly *activated* [MAPK] and increased the extent of attachment , spreading and migration on fibronectin and collagen type I ( P < 0.01 ) but not on collagen type IV . Positive_regulation MAPK3 TNF 11108246 756730 *activates* extracellular regulated kinase-1/2 ( ERK1/2 ) and [p38MAPK] . Positive_regulation MAPK3 TNF 11108836 757041 In RAW264 cells which differentiate into osteoclast-like multinucleated cells by TNF treatment alone , activation of p38 [mitogen activated protein (MAP) kinase] *induced* by murine was comparable to and independent of the receptor activator of necrosis factor-kappaB ligand . Positive_regulation MAPK3 TNF 11156586 780617 1. We have previously shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce interleukin-8 (IL-8) by human pulmonary vascular endothelial cells . Positive_regulation MAPK3 TNF 11167962 783068 It has previously been shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce cytokine , including RANTES , that N-acetylcysteine (NAC) attenuates cytokine production by human bronchial epithelial cells ( BECs ) , and that sensitivity to TNFalpha is inversely correlated with cellular redox state . Positive_regulation MAPK3 TNF 11221891 787469 To determine the role of KSR in *induced* [ERK1/ERK2] activation , we studied young adult mouse colon cells expressing a dominant negative , kinase-inactive ( ki ) KSR . Positive_regulation MAPK3 TNF 11221891 787478 We therefore conclude that KSR is an essential upstream regulator of *stimulated* [ERK1/ERK2] activation , most likely mediated via direct phosphorylation of Raf-1 . Positive_regulation MAPK3 TNF 11266661 797171 However , *caused* no activation of p42/p44 [MAPK] or cytosolic phospholipase A(2) activity . Positive_regulation MAPK3 TNF 11277995 798113 *activates* extracellular regulated kinases ( ERKs ) and p38 [mitogen activated protein kinase] ( p38MAPK ) , and inhibits the expression of uncoupling protein-1 (UCP-1) and adipocyte-specific genes in rat fetal brown adipocytes . Positive_regulation MAPK3 TNF 11319753 806841 SB 203580 , a selective inhibitor of p38 MAPK , inhibited IL-1 and *induced* p38 [MAPK] activity and IL-6 production ( IC ( 50 ) s 0.3 -- 0.5 microM ) in osteoblasts and chondrocytes . Positive_regulation MAPK3 TNF 11319753 806868 In addition , IL-1 and also *activated* p38 [MAPK] in fetal rat long bones and p38 MAPK inhibitors inhibited IL-1- and TNF stimulated bone resorption in vitro in a dose dependent manner ( IC ( 50 ) s 0.3 -- 1 microM ) . Positive_regulation MAPK3 TNF 11353829 815158 or IL-1 alone *activated* [ERK1/2] , p38 , and JNK maximally at 15 min in HUVEC . Positive_regulation MAPK3 TNF 11435466 832531 However , the cytotoxic responses to daunorubicin and exogenous ceramide remain unaltered , as do the *induced* p42/p44 [MAPK] activation and CD54 expression . Positive_regulation MAPK3 TNF 11438547 843396 *activated* p38 [MAPK] and p44/p42 MAPK in wild-type but not in p60 ( -/- ) , p80 ( -/- ) , or p60 ( -/- ) p80 ( -/- ) macrophages . Positive_regulation MAPK3 TNF 11489936 845476 Early [Erk1/2] activation was stimulated directly by SDF-1 alpha and late activation was *mediated* by . Positive_regulation MAPK3 TNF 11494147 846175 In this study we demonstrate that *triggers* only modest proliferation , as well as p44/p42 [mitogen activated protein kinase (MAPK)] and NF-kappaB activation , in MM.1S multiple myeloma ( MM ) cells . Positive_regulation MAPK3 TNF 11495721 846396 Furthermore , overexpression of dominant negative mutants , H-Ras-15A and Raf-N4 , significantly suppressed p42/p44 [mitogen activated protein kinase (MAPK)] activation *induced* by and PDGF-BB and attenuated the effect of TNF-alpha on BK-induced IP response , indicating that Ras and Raf may be required for activation of these kinases . Positive_regulation MAPK3 TNF 11509550 848366 Although IL-1 beta and each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK3 TNF 11592111 869665 Lipopolysaccharide (LPS) treatment of a microglial cell line ( N9 ) *induced* a time dependent activation of both p38 [mitogen activated protein kinase] ( p38 MAPK ) and nuclear factor-kappaB (NFkappaB) , with consequent increases in interleukin-1alpha (IL-1alpha) , , and nitric oxide ( NO ) production . Positive_regulation MAPK3 TNF 11689211 876135 Potential nuclear targets of *activated* [ERK 1/2] include the transcription factors Ets-1 , Egr-1 , and c-fos , which are known to regulate cellular growth , differentiation , and migration . Positive_regulation MAPK3 TNF 11689211 876146 *induced* [ERK 1/2] activation in both cell types . Positive_regulation MAPK3 TNF 11694522 896416 *activated* the three mammalian [MAPK] , p44/42 , JNK , and p38 , in a distinct time- and concentration dependent manner . Positive_regulation MAPK3 TNF 11694522 896442 In conclusion , although *activates* all three known [MAPK] in human preadipocytes , only p44/42 and JNK appear to be involved in the regulation of lipolysis . Positive_regulation MAPK3 TNF 11750919 898174 Biochemical and immunocytochemical analysis showed that *activated* p38 [mitogen activated protein kinase] ( p38MAPK ) and c-Jun N-terminal kinase (JNK) but not p42/p44 MAPK . Positive_regulation MAPK3 TNF 11795313 892318 ( 10 ng/ml ) alone *activated* both [ERK1/2] and JNK maximally at 15 minutes in human umbilical vein EC ( HUVEC ) . Positive_regulation MAPK3 TNF 11820362 908741 *activated* p38 [MAPK] and stimulated IL-6 secretion by MG-63 cells , and pre-incubation of cells with the p38 MAPK inhibitor abrogated TNF-alpha dependent IL-6 secretion . Positive_regulation MAPK3 TNF 11820362 908770 Transfection of IL-6 full-length and 5-deletion gene promoter reporter constructs indicated that p38 [MAPK] *activation* by enhanced IL-6 gene expression , and that the p38 MAPK-responsive region resided in the proximal 260-bp segment . Positive_regulation MAPK3 TNF 11820362 908806 In conclusion , although p38 [MAPK] *activation* by stimulates IL-6 secretion by MG-63 cells , it has opposing effects on c/EBPbeta and NFkappaB activity . Positive_regulation MAPK3 TNF 11930247 927421 The p44/42 [MAPK] activity was significantly *enhanced* by and the TNF-alpha effect was opposed by rhIL-10 . Positive_regulation MAPK3 TNF 11930247 927434 It is suggested that rhIL-10 can inhibit *induced* VSMC proliferation and phosphorylation of p44/42 [MAPK] . Positive_regulation MAPK3 TNF 12060661 975651 rapidly and transiently *activated* [ERK1/2] and JNK in fibroblasts , whereas the activation of p38 MAPK was more persistent . Positive_regulation MAPK3 TNF 12095140 960567 significantly increased permeability and *induced* p38 and ERK [MAPK] activation compared with controls ( P < 0.05 ) . Positive_regulation MAPK3 TNF 12114204 963997 *increased* the phosphorylation of p38 MAPK within 15 min. Anisomycin , an activator of p38 MAPK , increased p38 [MAPK] phosphorylation and decreased SP-A mRNA levels in a dose dependent manner . Positive_regulation MAPK3 TNF 12130576 966584 Phosphorylation of p38 [MAPK] was *induced* by RANKL , IL-1 , , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation MAPK3 TNF 12131776 966862 IL-1 beta and *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK3 TNF 12297009 991040 In this study , we examined the anti-apoptotic role of p38 [MAPK] that is *activated* by in neuronal PC12 cells . Positive_regulation MAPK3 TNF 12297009 991053 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Positive_regulation MAPK3 TNF 12393915 1025439 This model probiotic also inhibits *activation* of the pro-apoptotic [p38/mitogen activated protein kinase] by , interleukin-1alpha , or gamma-interferon . Positive_regulation MAPK3 TNF 12483539 1024798 In addition , PP1 substantially inhibited the IL-2beta- and dependent *activation* of [Erk 1/2] and Akt . Positive_regulation MAPK3 TNF 12511413 1079043 The treatment of RAW264 cells with TSA and NaB inhibited *induced* nuclear translocation of NF-kappa B and sRANKL induced activation of p38 [mitogen activated protein kinase (MAPK)] signals . Positive_regulation MAPK3 TNF 12526087 1028233 does not *induce* phosphorylation of [ERK1/ERK2] and S727 in ECV304 and smooth muscle cells . Positive_regulation MAPK3 TNF 12631113 1067618 Additional experiments examining the role of cAMP on MC fractalkine expression showed that the incubation of MCs with TNF-alpha and either db-cAMP or forskolin attenuated TNF-alpha stimulated fractalkine mRNA and protein expression , preceded by attenuation of *activated* phosphorylation of p42/44 [MAPK] , and c-Jun , but not phosphorylation of PKCzeta/iota or nuclear translocation of NF-kappaB . Positive_regulation MAPK3 TNF 12637577 1099314 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and *requires* p38 [MAPK] activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation MAPK3 TNF 12665666 1030373 This study was undertaken to examine the relationship between *induced* cardiomyocyte apoptosis and activation of p38 [mitogen activated protein kinase (MAPK)] through oxidative stress . Positive_regulation MAPK3 TNF 12665666 1030386 Corresponding to the apoptotic effect , at 10 ng/mL *caused* rapid phosphorylation of p38 [MAPK] in wild-type cardiomyocytes . Positive_regulation MAPK3 TNF 12686737 1078172 *activated* [ERK1/2] , JNK , and p38 maximally at 15 min in HUVEC . Positive_regulation MAPK3 TNF 12694807 1080912 *induced* the phosphorylation of p44/p42 [mitogen activated protein (MAP) kinase] and p38 MAP kinase . Positive_regulation MAPK3 TNF 12731668 1086848 On the other hand , GM-CSF- or *induced* phosphorylation of ERK and p38 [MAPK] was unaffected by these inhibitors at the concentrations effective for the inhibition of O2- release and adherence . Positive_regulation MAPK3 TNF 12829618 1113807 However , *induced* [p38-MAPK] phosphorylation was markedly diminished in mkk3-/- vs mkk3+/+ hearts ( percent basal , 127+/-23 versus 540+/-267 , respectively , P=0.04 ) , suggesting an MKK independent activation mechanism by ischemia . Positive_regulation MAPK3 TNF 12844496 1149731 Rho inhibition decreases induced endothelial [MAPK] *activation* and monolayer permeability . Positive_regulation MAPK3 TNF 12844496 1149744 Because GTP binding proteins have been implicated in MAPK activation , we now hypothesize that the GTP binding protein Rho is a mediator of induced [MAPK] *activation* and increased endothelial permeability . Positive_regulation MAPK3 TNF 12844496 1149758 C3 transferase attenuated induced [MAPK] *activation* and blocked TNF induced endothelial permeability . Positive_regulation MAPK3 TNF 12867430 1142004 Subsequently , mediated p38 [MAPK] *activation* induced sialidase activity and CD44-HA binding . Positive_regulation MAPK3 TNF 12867430 1142108 Taken together , our results suggest that *induced* p38 [MAPK] activation may regulate the induction of functionally active HA-binding form of CD44 by activating sialidase in LPS stimulated human monocytic cells . Positive_regulation MAPK3 TNF 12881424 1116133 Importantly , does not *induce* ROS accumulation or prolonged [MAPK] activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death Positive_regulation MAPK3 TNF 12893778 1121031 We show that MKK3 and MKK6are essential for *stimulated* p38 [MAPK] activation . Positive_regulation MAPK3 TNF 12960255 1158289 To investigate a potential interplay between *induced* activation of p38 [MAPK] and NF-kappaB , the p38 MAPK inhibitor SB203580 and a dominant negative p38 MAPK mutant were used . Positive_regulation MAPK3 TNF 14516792 1147205 [MAPK] pathway *activation* via was confirmed by marked AP-1 activation detected in EMSA . Positive_regulation MAPK3 TNF 14561851 1165107 In cultured human umbilical vein endothelial cells ( HUVECs ) , and lipopolysaccharide *increased* phosphorylation of p38 [MAPK] ( P-p38 MAPK ) and increased ICAM-1 expression . Positive_regulation MAPK3 TNF 14592823 1209466 Analyzing the individual contribution of PF-4 and its costimuli in the control of these functions at the signaling level , we demonstrate that induced *activation* of p38 [mitogen activated protein (MAP) kinase] ( but not extracellular regulated kinase [ Erk ] kinases ) acts as general and essential costimulatory signal in PF-4 dependent neutrophil exocytosis . Positive_regulation MAPK3 TNF 14632659 1170652 *activated* p38 [MAPK] in DCs only at an early time-point ( 15 min ) . Positive_regulation MAPK3 TNF 14654378 1176830 These findings suggest that the pre-ischemic *activation* of [p38-MAPK] by does not contribute to cardioprotection afforded by this agent . Positive_regulation MAPK3 TNF 15002040 1265084 Consistent with the abrogation of osteoclastogenic effect of DcR3 by TNFR-Fc , DcR3 treatment can *induce* osteoclastogenic cytokine release through ERK and p38 [MAPK] signaling pathways . Positive_regulation MAPK3 TNF 15087472 1258135 Stimulatory effects of on neuropeptide gene expression and release appeared to be mediated through the type 2 TNF-alpha receptor , and *required* activation of [ERK 1/2] and p38 , but not Janus kinase , MAPKs . Positive_regulation MAPK3 TNF 15139014 1246959 The increase in release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not [mitogen activated protein kinase (MAPK)] , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation MAPK3 TNF 15191888 1295241 Treatment of endothelial cells with SphK1 siRNA suppressed *induced* increase in MCP-1 mRNA levels , MCP-1 protein secretion , and activation of p38 [MAPK] . Positive_regulation MAPK3 TNF 15212763 1262320 Interestingly , Ad5NIK , but not , *induces* RelA S536 and p38 [mitogen activated protein kinase (MAPK)] phosphorylation in IKKgamma ( -/- ) cells . Positive_regulation MAPK3 TNF 15233873 1269392 A. semen also inhibited the expression of and the *activation* of mitogen activated protein kinase , [ERK1/2] , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation MAPK3 TNF 15240695 1270284 TNF activates Syk protein tyrosine kinase leading to *induced* [MAPK] activation , NF-kappaB activation , and apoptosis . Positive_regulation MAPK3 TNF 15240695 1270304 TNF induced Syk activation was abolished by piceatannol ( Syk-selective inhibitor ) , which led to the suppression of induced *activation* of c- JNK , p38 MAPK , and p44/p42 [MAPK] . Positive_regulation MAPK3 TNF 15240695 1270320 Jurkat cells that did not express Syk ( JCaM1 , JCaM1/lck ) showed lack of *induced* Syk , JNK , p38 [MAPK] , and p44/p42 MAPK activation , as well as TNF induced IkappaBalpha phosphorylation , IkappaBalpha degradation , and NF-kappaB activation . Positive_regulation MAPK3 TNF 15240695 1270351 Overall , our results demonstrate that Syk activation plays an essential role in induced *activation* of JNK , p38 MAPK , p44/p42 [MAPK] , NF-kappaB , and apoptosis . Positive_regulation MAPK3 TNF 15240725 1270459 p38 [MAPK] was *activated* by and oxidants in nonadherent conditions i.e. , with 10 mM EDTA . Positive_regulation MAPK3 TNF 15240725 1270473 Finally , p38 [MAPK] *activation* by was blocked by diphenylene iodonium , an inhibitor of flavoprotein oxidoreductase , and by the free radical scavenger N-acetylcystein . Positive_regulation MAPK3 TNF 15265936 1275735 Besides NF-kappa B , celecoxib also suppressed *induced* JNK , p38 [MAPK] , and ERK activation . Positive_regulation MAPK3 TNF 15290420 1278552 Halothane or isoflurane augmented the LPS- and *induced* activation of p38 [MAPK] . Positive_regulation MAPK3 TNF 15304089 1284481 DNCB , NiSO ( 4 ) and *activated* p38 [mitogen activated protein kinases (MAPK)] and c-jun N-terminal kinase ( JNK ) . Positive_regulation MAPK3 TNF 15322069 1333423 We have also investigated the phosphorylation of p42/44 [MAPK] and *upregulation* of RhoA protein by . Positive_regulation MAPK3 TNF 15452110 1341994 In contrast , *induced* p42/p44 [MAPK] activation and CD54 expression remained unaltered . Positive_regulation MAPK3 TNF 15507370 1327954 Chrysanthemi sibirici herba also inhibited the expression of and the *activation* of the MAP kinase , [ERK1/2] , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of activating phosphorylation of ERK1/2 . Positive_regulation MAPK3 TNF 15589482 1356214 In addition , luteolin inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , IkappaB degradation , and NF-kappaB activation . Positive_regulation MAPK3 TNF 15659876 1350310 The anabolic effect of was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an extracellular regulated kinases (ERK) . Positive_regulation MAPK3 TNF 15696169 1372164 Using TCPTP-deficient fibroblasts , we show here that TCPTP regulates *induced* [MAPK] but not NF-kappaB signaling . Positive_regulation MAPK3 TNF 15696169 1372203 These results link TCPTP and Src tyrosine kinases to the selective regulation of *induced* [MAPK] signaling and identify a previously unknown mechanism for modulating inflammatory responses mediated by TNF . Positive_regulation MAPK3 TNF 15703956 1497470 *Activation* of p38 [mitogen activated protein (MAP) kinase] and phosphatidylinositol 3-kinase (PI3K) by was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation MAPK3 TNF 15743827 1379088 Knockdown of TRAF4 expression using siRNA had no effect on p47phox phosphorylation or binding to p22phox but inhibited *induced* [ERK1/2] activation . Positive_regulation MAPK3 TNF 15743827 1379091 In coronary microvascular EC from p47phox-/- mice , induced NADPH oxidase activation , [ERK1/2] *activation* , and cell surface intercellular adhesion molecule 1 ( ICAM-1 ) expression were all inhibited . Positive_regulation MAPK3 TNF 15792609 1386796 By stimulation of in AM-1 cells , the phosphorylation of Akt ( Ser473 ) and p44/42 [mitogen activated protein kinase (MAPK)] ( Thr202/Tyr204 ) was markedly *increased* in TNFalpha concentration and time dependent manner . Positive_regulation MAPK3 TNF 15792609 1386809 Pretreatment with U0126 , mitogen activated extracellular regulated kinase ( MEK) 1/2 inhibitor , prior to TNFalpha stimulation , specifically inhibited *induced* phosphorylation of p44/42 [MAPK] ( Thr202/Tyr204 ) in AM-1 cells . Positive_regulation MAPK3 TNF 15792609 1386825 Meanwhile , pretreatment with LY294002 , phosphatidylinositol-3-OH kinase (PI3K) inhibitor , could inhibit both *induced* phosphorylation of Akt ( Ser473 ) and p44/42 [MAPK] ( Thr202/Tyr204 ) . Positive_regulation MAPK3 TNF 15823554 1393914 Furthermore , potently *activated* p38 [MAPK] , JNK , and NF-kappaB . Positive_regulation MAPK3 TNF 15837794 1432551 Expression of this protein inhibited induced *activation* of NFkappaB , JNK , and p38 [MAPK] and sensitized the cells to TNF induced apoptosis . Positive_regulation MAPK3 TNF 15845648 1425549 *induces* a more than tenfold increase in p38 [mitogen activated protein kinase (MAPK)] but not extracellular signal regulated kinase phosphorylation . Positive_regulation MAPK3 TNF 15870903 1405549 In addition , GA inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , I kappa B alpha degradation , and NF-kappa B activation . Positive_regulation MAPK3 TNF 15979106 1459098 The involvement of this nucleoside in the *activation* of [ERK 1/2] by was also investigated . Positive_regulation MAPK3 TNF 16009485 1441407 Moreover , p44/42 [mitogen activated protein kinase] appears to partly *mediate* the negative effect of insulin but not on ATGL . Positive_regulation MAPK3 TNF 16023081 1441590 Ellagic acid inhibited IL-1beta- and induced *activation* of activator protein-1 and mitogen activated protein kinases ( extracellular signal regulated kinase , c-Jun N-terminal kinase and p38 [mitogen activated protein kinase] ) , but not of nuclear factor-kappaB . Positive_regulation MAPK3 TNF 16025396 1435613 *activated* the phosphorylation of p44/42 MAPK , p38 [MAPK] , SAPK/JNK and Akt in mesangial cells . Positive_regulation MAPK3 TNF 16025396 1435629 PGE1 inhibited the *induced* phosphorylation of SAPK/JNK and Akt , but not p44/42 MAPK and p38 [MAPK] . Positive_regulation MAPK3 TNF 16080915 1442769 Comparative gene array analysis of *induced* [MAPK] and NF-kappaB signaling pathways between retinal ganglion cells and glial cells . Positive_regulation MAPK3 TNF 16094077 1443624 also *activated* NF-kappaB , AP-1 and [ERK1/2] . Positive_regulation MAPK3 TNF 16140562 1499255 These results suggested that TNFalpha induced both cell survival and apoptosis pathways in ameloblastoma and potential of TNFalpha in inducing apoptosis can be improved by inhibiting *induced* Akt and p44/42 [mitogen activated protein kinase (MAPK)] cell survival pathways . Positive_regulation MAPK3 TNF 16141211 1467201 also *activated* [ERK1/2] . Positive_regulation MAPK3 TNF 16253760 1471889 U0126 , an inhibitor of MEK1/2 , inhibited the *induced* activation of [extracellular signal regulated kinase 1/2] ( ERK1/2 ) and the metastatic properties in vitro without affecting cell proliferation . Positive_regulation MAPK3 TNF 16275991 1480304 Angiotensin II , , or epidermal growth factor *induced* [MAPK] phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation MAPK3 TNF 16291729 1526072 *Activation* of [MAPK] and Akt by anti-HER2/neu inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation MAPK3 TNF 16314440 1487001 treatment *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation in NPCs , and SB202190 , an inhibitor of p38 MAPK , blocked TNF-alpha induced chemokine production . Positive_regulation MAPK3 TNF 16325162 1511666 Furthermore , APE1/ref-1 overexpression inhibited the *induced* increase in intracellular superoxide and p38 [MAPK] phosphorylation . Positive_regulation MAPK3 TNF 16442440 1516898 We now define distinct signaling pathways that regulate induction of and *activation* of [ERK1/2] by intracellular signaling mechanisms during M. bovis infection . Positive_regulation MAPK3 TNF 16452991 1611740 Western blots showed that IL-1beta and *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK3 TNF 16517732 1530940 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of , but not IL-6 , *requires* the activity of p38 [MAPK] . Positive_regulation MAPK3 TNF 16520344 1555068 Stimulation of HIPEC 65 cells with *caused* phosphorylation of JNK and [extracellular signal regulated kinase 1/2] ( Erk1/2 ) , with a peak after 20 min of treatment . Positive_regulation MAPK3 TNF 16573652 1556138 HA-mediated production *required* p38 [MAPK] , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation MAPK3 TNF 16682409 1584059 Further , the deletion of NQO1 abolished induced c-Jun N-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] *activation* . Positive_regulation MAPK3 TNF 16781693 1585617 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and and the *activation* of [MAPK] 's are potentially positive signals for IL-10 production . Positive_regulation MAPK3 TNF 16798728 1638521 Inhibition of Rac1 does not modulate induced [ERK1/2] and Akt *activation* . Positive_regulation MAPK3 TNF 16798728 1638536 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Positive_regulation MAPK3 TNF 16875982 1593564 *activates* [p38-MAPK] , a stress-responsive kinase implicated in contractile depression and cardiac injury . Positive_regulation MAPK3 TNF 16875982 1593578 Under conditions of constant coronary flow , the [p38-MAPK] activation and contractile depression *induced* by , though attenuated , remained sensitive to the absence of MKK3 or the presence of SB203580 . Positive_regulation MAPK3 TNF 16875982 1593592 *activates* [p38-MAPK] in the intact heart and in isolated cardiac myocytes through MKK3 . Positive_regulation MAPK3 TNF 16982923 1617364 Compared with wild-type cells , MIF-deficient cells were hyporesponsive to IL-1- and *induced* [MAPK] activity , AP-1 activity , and cellular proliferation , while NF-kappaB function was preserved . Positive_regulation MAPK3 TNF 17012372 1674163 MXF inhibited *stimulated* MAPKs [ERK1/2] , 46-kDa JNK , and NF-kappaB up to 60 % , 40 % , and 40 % , respectively . Positive_regulation MAPK3 TNF 17031853 1683069 Exogenously added PGE ( 2 ) potently inhibited induced both MMP-1 production and *activation* of [ERK1/2] . Positive_regulation MAPK3 TNF 17059425 1683928 Zoledronate reduced Ras prenylation , Ras and RhoA translocation to the membrane , and sustained [ERK1/2] phosphorylation and *induced* JNK phosphorylation . Positive_regulation MAPK3 TNF 17070777 1649836 Inhibition of Syk down-regulated *induced* p38 and p44/42 [MAPK] phosphorylation and nuclear translocation of p65 NF-kappaB . Positive_regulation MAPK3 TNF 17099067 1676202 Importantly , Dex is able to increase the expression of MKP-1 , which causes an inactivation of *induced* p38 [MAPK] and mediates inhibition of E-selectin expression . Positive_regulation MAPK3 TNF 17126899 1677675 Stimulation of ECs with *induced* rapid increases in the phosphorylation of their mitogen activated protein kinases ( MAPKs ) [ extracellular signal regulated kinase ( ERK ) , c-Jun-NH2-terminal kinase (JNK) , and p38 [MAPK] ] ; Positive_regulation MAPK3 TNF 17126905 1686551 Differential regulation of and GM-CSF *induced* activation of P38 [MAPK] in neutrophils and eosinophils . Positive_regulation MAPK3 TNF 17138860 1653548 The role of delta-PKC in *mediated* activation of [MAPK] is not known . Positive_regulation MAPK3 TNF 17138860 1653574 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 MAPK are involved in TNF antiapoptotic signaling and whether delta-PKC is a key regulator of [MAPK] *activation* by . Positive_regulation MAPK3 TNF 17138860 1653600 In human neutrophils , *activated* both p38 [MAPK] and ERK1/2 principally via TNFR-1 . Positive_regulation MAPK3 TNF 17138860 1653606 A specific delta-PKC antagonist , V1.1delta-PKC-Tat peptide , inhibited mediated [ERK1/2] *activation* , but not p38 MAPK . Positive_regulation MAPK3 TNF 17158449 1694260 A green fluorescent protein fusion protein containing the last 100 residues of TAK1 ( TAK1-C100 ) abolished the interaction of endogenous TAB2/TAB3 with TAK1 , the phosphorylation of TAK1 , and prevented the activation of IKK and [MAPK] *induced* by IL-1 , , and RANKL . Positive_regulation MAPK3 TNF 17161959 1694540 Upon examination of the signaling components , we found that was a potent *activator* of p38 , p44/42 , p54/46 [MAPK] , and IkappaBalpha ( IkappaBalpha ) . Positive_regulation MAPK3 TNF 17172975 1679388 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the [MAPK] , and production of . Positive_regulation MAPK3 TNF 17172975 1679414 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the [MAPK] , and production of . Positive_regulation MAPK3 TNF 17189827 1680169 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Positive_regulation MAPK3 TNF 17202326 1680816 Augmented lipopolysaccharide induced production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK3 TNF 17202326 1680842 In this study , we show that augmented LPS induced production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK3 TNF 17218473 1732519 The RhoA inhibitor C3 exoenzyme and the ROCK inhibitor Y-27632 both attenuated induced [MAPK] *activation* and blocked AR expression in HIMEC . Positive_regulation MAPK3 TNF 17220297 1703055 TRAF2 and ASK1 play essential roles in *induced* [mitogen activated protein kinase] signaling . Positive_regulation MAPK3 TNF 17227768 1703823 We tested whether mitogenic activated protein kinase kinase kinase kinase isoform 4 ( MAP4K4 ) causes the *induced* negative regulation of [extracellular signal regulated kinase-1/2] ( ERK-1/2 ) , c-Jun NH2-terminal kinase (JNK) , and the insulin receptor substrate-1 (IRS-1) on the insulin signaling pathway governing glucose metabolism . Positive_regulation MAPK3 TNF 17258890 1725456 The effects of and FasL on GrB expression were specifically *mediated* by [p38MAPK] ( Mitogen-activated-protein-kinase ) activation . Positive_regulation MAPK3 TNF 17425653 1748785 The percentage increases in IL-18 induced phosphorylation of extracellular signal regulated kinase ( ERK ) in Th cells of NDN and DN were significantly higher than controls ( P < 0.05 ) , while the percentage increase in *induced* phosphorylation of p38 [MAPK] in monocytes and IL-18 induced phosphorylation of p38 MAPK in Th cells and monocytes were significantly higher in NDN patients than controls . Positive_regulation MAPK3 TNF 17438131 1742777 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation MAPK3 TNF 17438336 1749077 FAK promoted *stimulated* [MAPK] activation needed for maximal IL-6 production . Positive_regulation MAPK3 TNF 17438336 1749099 Analysis of FAK ( -/- ) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity , Tyr-397 phosphorylation , and the Pro-712/713 proline-rich region of FAK were required for *stimulated* [MAPK] activation and IL-6 production . Positive_regulation MAPK3 TNF 17446186 1749512 *increased* p38 [MAPK] phosphorylation , potently stimulated IRS-1 serine phosphorylation , and blunted insulin stimulated IRS-1 tyrosine and Akt phosphorylation and eNOS activity . Positive_regulation MAPK3 TNF 17446186 1749519 also potently *stimulated* the phosphorylation of [ERK1/2] and AMPK . Positive_regulation MAPK3 TNF 17446186 1749527 Treatment with SB203580 decreased p38 MAPK phosphorylation back to the baseline and restored insulin sensitivity of IRS-1 tyrosine and Akt phosphorylation and eNOS activity in TNF-alpha treated bAECs without affecting *induced* [ERK1/2] and AMPK phosphorylation . Positive_regulation MAPK3 TNF 17446186 1749534 We conclude that in cultured bAECs , induces insulin resistance in the phosphatidylinositol 3-kinase/Akt/eNOS pathway via a p38 MAPK dependent mechanism and *enhances* [ERK1/2] and AMPK phosphorylation independent of the p38 MAPK pathway . Positive_regulation MAPK3 TNF 17531219 1762172 On the other hand , aloe emodin did not affect *induced* activation of p38 [mitogen activated protein kinase] or generation of reactive oxygen species . Positive_regulation MAPK3 TNF 17572510 1774274 This protection occurs without decreasing global activity of TNF receptors since IL-10 does not impair *induced* IL-6 synthesis or [ERK1/2] phosphorylation . Positive_regulation MAPK3 TNF 17575006 1786104 Both U0126 , an inhibitor of MEK1/2 , and dominant negative ERK1 prevented TNF-alpha induced MUC1 promoter activation , and anti-TNFR1 antibody blocked *stimulated* [ERK1/2] activation . Positive_regulation MAPK3 TNF 17607712 1798191 Although *induced* the activation of p38 [MAPK] , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation MAPK3 TNF 17725582 1801636 MAC inhibited *induced* p38 [mitogen activated protein kinase] activation and cell death in cultured Schwann cells . Positive_regulation MAPK3 TNF 17895408 1823967 IA did not interfere with induced *activation* of c-Jun N-terminal kinase (JNK) and p38 [mitogen activated protein kinase] . Positive_regulation MAPK3 TNF 17906365 1803235 Dexamethasone ( DEX ; 10 ( -12 ) -10 ( -4 ) M ) reduced *induced* phosphorylation of [ERK-1/-2] and prevented TNFalpha induced VEGF generation without differences between non-smokers , smokers with and without COPD . Positive_regulation MAPK3 TNF 17942934 1814216 Deletion of NQO2 also abolished induced c-Jun NH2-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] *activation* . Positive_regulation MAPK3 TNF 17971516 1859766 *activated* two signaling cascades : 1 ) [ERK1/2] and its target eIF4E and 2 ) Akt and its downstream effectors GSK-3 , p70 ( S6K ) , and 4E-BP1 . Positive_regulation MAPK3 TNF 17971516 1859770 *induced* phosphorylation of Akt , and [ERK1/2] was inhibited by an antibody against TNF-alpha receptor 1 (TNF-R1) . Positive_regulation MAPK3 TNF 17971516 1859772 PD-98059 pretreatment abolished *induced* phosphorylation of [ERK1/2] and eIF4E , whereas PS was only partially inhibited . Positive_regulation MAPK3 TNF 17994109 1851164 triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 [MAPK] , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation MAPK3 TNF 18039275 1828530 Further downstream in this axis of signalling , blockade *reduces* only acute bronchoconstriction , while [MAPK] inhibition abrogates completely endotoxin induced inflammation . Positive_regulation MAPK3 TNF 18060043 1853604 In cultures of Schwann cells , astrocytes , and microglia , sLRP-alpha inhibited *induced* activation of p38 [MAPK] and ERK/MAPK . Positive_regulation MAPK3 TNF 18060869 1846779 *stimulated* MMP-9 expression and [Erk1/2] activation were both significantly inhibited by LOX-PP. Immunohistochemistry studies carried out with affinity purified anti-LOX-PP antibody showed that LOX-PP epitopes were expressed at elevated levels in vascular lesions of injured arteries . Positive_regulation MAPK3 TNF 18061162 1861518 We demonstrate that *induced* proliferation of C4HD murine mammary tumor cells and of T47D cells through the activation of p42/p44 [MAPK] , JNK , PI3-K/Akt pathways and nuclear factor-kappa B (NF-kappa B) transcriptional activation . Positive_regulation MAPK3 TNF 18091748 1847369 *induced* phosphorylation of extracellular signal regulated kinase ( ERK ) and Akt , but not p38 [mitogen activated protein kinase (MAPK)] , was attenuated by nicardipine , cilnidipine , benidipine , efonidipine , and azelnidipine . Positive_regulation MAPK3 TNF 18227157 1884368 It was shown that these three proteins could ( i ) induce expression of and tissue factor and ( ii ) *induce* phosphorylation of p44/42 [mitogen activated protein kinases (MAPK)] and activation of early growth response factor 1 (Egr-1) . Positive_regulation MAPK3 TNF 18258304 1884798 However , over-expression of a dominant negative form of Rac strongly inhibited *induced* p42/44 [MAPK] kinase activation , but had little effect upon JNK and no effect upon p38 MAPK activity . Positive_regulation MAPK3 TNF 18287053 1872491 Here , we show that the murine CMV M45 protein binds to RIP1 and inhibits induced *activation* of NF-kappaB , p38 [MAPK] , and caspase independent cell death . Positive_regulation MAPK3 TNF 18287248 1896527 Flavopiridol suppresses *induced* activation of activator protein-1 , c-Jun N-terminal kinase , p38 [mitogen activated protein kinase (MAPK)] , p44/p42 MAPK , and Akt , inhibits expression of antiapoptotic gene products , and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells . Positive_regulation MAPK3 TNF 18310456 1879064 Simvastatin potently suppressed *induced* phosphorylation of [ERK1/2] and SAPK/JNK by inhibiting TNF-alpha induced membrane localization of Ras and RhoA . Positive_regulation MAPK3 TNF 18314542 1931908 P < 0.05 ) , and MKP-1 up-regulation was temporally related to the inhibition of *induced* p38 [MAPK] phosphorylation . Positive_regulation MAPK3 TNF 18336852 1912242 *stimulated* phosphorylation of p42/p44 [MAPK] and JNK were attenuated by pretreatment with the inhibitors U0126 and SP600125 or transfection with dominant negative mutants of DeltaERK and DeltaJNK . Positive_regulation MAPK3 TNF 18364436 1912770 We , for the first time , demonstrate that binding of staphylococcal enterotoxin B to MHC-II results in activation of TNF-alpha converting enzyme , epidermal growth factor receptor , [p38MAPK] , and NF-kappaB *inducing* biphasic production . Positive_regulation MAPK3 TNF 18387509 1893184 All three compounds failed to block *induced* phosphorylation of [ERK1/2] , which is involved in regulating ICAM-1 production by TNF-alpha . Positive_regulation MAPK3 TNF 18443205 1938528 Conversely , *induced* increases in insulin receptor substrate-1 serine phosphorylation ( Ser ( 312 ) ) , Jun NH ( 2 ) -terminal kinase phosphorylation , and extracellular signal related kinase-1/2 [mitogen activated protein kinase (MAPK)] phosphorylation were unaltered by siRNA mediated IKKbeta reduction . Positive_regulation MAPK3 TNF 18518937 1971922 Although Cot/Tpl2 was phosphorylated in IRI and in the cultured tubular epithelial cells (TEC) after stimulation with LPS and hydrogen peroxide , there were no significant differences in terms of production , neutrophil infiltration or [MAPK] *activation* between Cot/Tpl2 ( +/+ ) and Cot/Tpl2 ( -/- ) mice . Positive_regulation MAPK3 TNF 18557926 1984201 In this work , we demonstrate that in the premalignant keratinocyte cell line HaCaT , *activates* Akt , [ERK1/2] and p38 . Positive_regulation MAPK3 TNF 18557926 1984205 The *dependent* phosphorylation of [Akt-ERK1/2] was slightly decreased by NF kappaB inhibition and in the presence of p38 blockers . Positive_regulation MAPK3 TNF 18636175 1937272 Furthermore , glucosamine inhibited the *induced* phosphorylation of [p38MAPK] and NF-kappaB p65 , and the nuclear translocation of NF-kappaB in the cells . Positive_regulation MAPK3 TNF 18653803 1960519 PMA stimulated nSMase2 translocation was independent of p38 MAPK , and neither PKC inhibitors nor small interfering RNA had significant effects on *stimulated* p38 [MAPK] activation , indicating that PKC-delta does not act through p38 MAPK in regulating nSMase2 . Positive_regulation MAPK3 TNF 18710428 2028203 As for the signalling pathway , stimulation *led* to the phosphorylation of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and translocation of nuclear factor kappaB (NF-kappaB) ( p65 ) into the nuclei . Positive_regulation MAPK3 TNF 18710428 2028227 These data suggest that interaction *leads* to the phosphorylation of Erk1/2 and [p38MAPK] and nuclear translocation of NF-kappaB , which is closely associated with the production and activation of MMP-9 in cultured CC cells of HuCTT-1 and CCKS-1 . Positive_regulation MAPK3 TNF 18768892 1957225 Consistently , Nod2-null macrophages tolerant to LPS and MDP showed enhanced production of and IL-6 as well as increased NF-kappaB and [MAPK] *activation* in response to the dipeptide KF1B , the Nod1 agonist . Positive_regulation MAPK3 TNF 18773430 1969108 Furthermore , Western blot analysis indicated *induced* phosphorylation of [extracellular signal regulated kinase 1] and 2 ( ERK1/2 ) , p38 and c-Jun N-terminal kinase (JNK) were inhibited by THBA . Positive_regulation MAPK3 TNF 18948845 2053242 Hypertonic saline did not alter *induced* p38 [mitogen activated protein kinase] phosphorylation or constitutive vascular endothelial growth factor expression , suggesting that the observed inhibition is not a generalized suppression of protein phosphorylation or cellular function . Positive_regulation MAPK3 TNF 18981572 1983609 Rb1 also effectively blocked *induced* activation of p38 , c-Jun N-terminal protein kinase , [extracellular signal regulated kinase 1/2] and IkappaBalpha . Positive_regulation MAPK3 TNF 19013539 2071199 Furthermore , Western blot analysis indicated that the *induced* phosphorylation of [extracellular signal regulated kinase 1] and 2 ( ERK1/2 ) , p38 and c-Jun N-terminal kinase (JNK) were strongly inhibited by DPT . Positive_regulation MAPK3 TNF 19100731 2031223 at 30 ng/ml significantly *increased* phosphorylation of receptor tyrosine kinase ( 175 kDa ) and p42 [mitogen activated protein (MAP) kinase] . Positive_regulation MAPK3 TNF 19130554 2025302 Stimulation of HIMEC with *triggered* phosphorylation of the [MAPK] , and up-regulation of VCAM-1 , FKN and ICAM-1 . Positive_regulation MAPK3 TNF 19234337 2079512 Analysis of downstream signals showed that inhibition of NAD(P)H oxidase partially inhibited NF-kappaB activation but did not reduce CCL2 mRNA stability or prevent *induced* phosphorylation of [p38MAPK] . Positive_regulation MAPK3 TNF 19275968 2072846 *stimulated* the phosphorylation levels of p38 [MAPK] , JNK , ERK1/2 and Akt in vascular endothelial cells . Positive_regulation MAPK3 TNF 19289468 2073040 The requirement for MADD was highly specific for induced *activation* of [MAPK] but not the related JNK and p38 kinases . Positive_regulation MAPK3 TNF 19371952 2081764 Of note , the IFN-gamma plus *stimulated* activation of p38 [MAPK] was suppressed following incubation with forskolin or DBcAMP alone . Positive_regulation MAPK3 TNF 19410630 2089697 By transfection of TAK1 siRNA , *induced* phosphorylation of IkappaBalpha , JNK1/2 , and [p38MAPK] , as well as IL-6 or IL-8 expression , were repressed . Positive_regulation MAPK3 TNF 19427347 2106796 *induced* the phosphorylation of p38 [mitogen activated protein (MAP) kinase] , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation MAPK3 TNF 19429670 2106867 Ang II and clearly *enhanced* ERK and [p38MAPK] phosphorylation . Positive_regulation MAPK3 TNF 19563733 2122010 Finally , EZS inhibited *induced* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phosphorylation . Positive_regulation MAPK3 TNF 19631264 2143006 The treatment of cells with piceatannol inhibited cell proliferation by reducing extracellular signal regulated kinase ( [ERK) 1/2] and JNK activity in cultured VSMC in the *presence* of . Positive_regulation MAPK3 TNF 19643162 2132349 SOCS-3 inhibited *induced* phosphorylation of the mitogen activated protein kinases [ERK1/2] , p38 and JNK in INSr3 # 2 cells and in primary rat islets . Positive_regulation MAPK3 TNF 19648110 2138333 This correlates with reduced *stimulated* p38 [MAPK] phosphorylation . Positive_regulation MAPK3 TNF 19648110 2138348 Repression of *induced* p38 [MAPK] phosphorylation , NF-kappaB dependent transcription , and IL-8 expression by dexamethasone are sensitive to transcriptional or translational inhibitors . Positive_regulation MAPK3 TNF 19648110 2138419 Thus , MKP-1 attenuates dependent *activation* of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Positive_regulation MAPK3 TNF 19648110 2138446 Small interfering RNA knockdown of dexamethasone induced MKP-1 expression partially reverses the repression of *activated* p38 [MAPK] , demonstrating that MKP-1 participates in the dexamethasone dependent repression of this pathway . Positive_regulation MAPK3 TNF 19788916 2163924 ( TNF-alpha ) and H ( 2 ) O ( 2 ) *activate* [mitogen activated protein kinase (MAPK)] in SH-SY5Y cells within 5 min and this activation is completely blocked by DLPC ( 12 microM ) . Positive_regulation MAPK3 TNF 19877072 2160713 CpdA also displayed profound effects on induced [MAPK] *activation* . Positive_regulation MAPK3 TNF 19877072 2160730 In sharp contrast , DEX did not affect *induced* IKK phosphorylation , IkappaBalpha degradation , p65 nuclear translocation , or [MAPK] activation in RA FLS . Positive_regulation MAPK3 TNF 19889458 2197305 Calpain inhibition induces random migration in TNF-alpha stimulated cells and prevents the generation of reactive oxygen species , but does not alter *mediated* activation of p38 [MAPK] and ERK MAPK . Positive_regulation MAPK3 TNF 20056194 2201028 We further demonstrated that the phosphorylation of [ERK1/2] was strongly *enhanced* by and FN compared to the application of either one alone . Positive_regulation MAPK3 TNF 20056194 2201029 Synergistic effect on ERK1/2 phosphorylation was also detected by TNF-alpha and activating beta1 integrin antibody , whereas inhibitory antibody to beta1 integrin attenuated FN and *induced* phosphorylation of [ERK1/2] . Positive_regulation MAPK3 TNF 20064929 2212147 The EGFR dependent stimulation of UTP induced [ERK1/2] phosphorylation in HSG cells is *inhibited* by the adamalysin inhibitor protease inhibitor or by small interfering RNA that selectively silences ADAM10 and ADAM17 expression , suggesting that ADAM metalloproteases are required for P2Y(2)R mediated activation of the EGFR . Positive_regulation MAPK3 TNF 20091890 2212751 In addition , ACSO also inhibited *induced* phosphorylation of JNK , [ERK1/2] and IkappaB , but not p38 . Positive_regulation MAPK3 TNF 20131228 2219914 Furthermore , addition of exogenous IL-18BPa-Fc reduced the RA synovial fibroblast phosphorylation of [ERK-1/2] *induced* by . Positive_regulation MAPK3 TNF 20181658 2259187 Taken together , TCDD stimulates expression and secretion of TNF-alpha in adipocytes through activation of AhR , [ERK1/2] , and JNK , and the secreted *causes* the downregulation of IRbeta , IRS1 , and GLUT4 through TNFR1 , resulting in insulin resistance . Positive_regulation MAPK3 TNF 20231691 2237860 TNF-alpha treatment resulted in the phosphorylation of p38 MAPK and its downstream target , MAPK activated protein kinase-2 , but IFN-gamma did not affect the levels of [MAPK] and MAPK activated protein kinase-2 phosphorylation *induced* by . Positive_regulation MAPK3 TNF 20489729 2327422 induced *activation* of p38 [MAPK] and the production of inducible nitric oxide synthase were suppressed in ASK1-deficient Müller glial cells . Positive_regulation MAPK3 TNF 20537761 2289692 Finally , PPARgamma-overexpression results in a reduction of [ERK1/2] phosphorylation and inflammatory secretions in *response* to and IFNgamma even in the absence of RGZ , suggesting a restraining effect controlled by endogenous ligands . Positive_regulation MAPK3 TNF 20646342 2292551 Effects of budesonide on P38 [MAPK] activation , apoptosis and IL-8 secretion , *induced* by and Haemophilus influenzae in human bronchial epithelial cells . Positive_regulation MAPK3 TNF 20646342 2292579 *induced* a significant increase in p38 [MAPK] phosphorylation . Positive_regulation MAPK3 TNF 20693316 2351480 In four of the six donors , basal and *induced* ERK and p38 [MAPK] activation were higher in ASMA than ASMNA cells . Positive_regulation MAPK3 TNF 20696856 2351511 Surprisingly , replenishment with exogenous GSH normalizes both *dependent* NF-?B as well as [MAPK] signaling and rescues hepatocytes from FKB induced death . Positive_regulation MAPK3 TNF 20951126 2364962 Taken together , this study provided first evidence demonstrating that TRAIL- , , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK3 TNF 20977504 2365403 In addition , histamine , IL-4 and *increased* JNK and [ERK1/2] expression . Positive_regulation MAPK3 TNF 21072492 2366052 We found that overexpression of the GM3 synthase gene inhibited DNA synthesis and [ERK1/2] activity *induced* by in VSMC , whereas the basal levels of DNA synthesis and ERK1/2 activity remained unchanged . Positive_regulation MAPK3 TNF 21123734 2377724 The ability of CO to inhibit *induced* ERK1/2 and p38 [MAPK] activities in an Akt dependent manner appears to be the key element in ROS dependent survival of endothelial cells during TNF-a mediated brain inflammatory disease . Positive_regulation MAPK3 TNF 21181166 2499613 IL-1ß and *activated* the intracellular mitogen activated protein kinases ( MAPKs ) : p44/42 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) as well as nuclear factor-?B ( NF-?B ) in osteoblasts . Positive_regulation MAPK3 TNF 21191629 2425311 *induced* phosphorylation of [ERK1/2] and JNK , and TNF-a induced IL-6 expression and release were inhibited by selective ERK1/2 and JNK blockers . Positive_regulation MAPK3 TNF 21212994 2726121 ( 10 ng/ml ) increased ERK1/2 levels 1.76 ± 0.23-fold ( P < 0.01 ) after 25 mmol/l glucose pretreatment , but added glucose did not *enhance* [ERK1/2] activation when given subsequent to TNF-a treatment . Positive_regulation MAPK3 TNF 21285293 2425728 Inhibitors of NADPH oxidase and/or p47phox siRNA diminished ROS production and COX-2 expression as well as phosphorylation of p38 [mitogen activated protein kinase] ( p38MAPK ) and Akt *mediated* either by AS serum or by . Positive_regulation MAPK3 TNF 21320357 2393859 The effects of IL-1ß and on EPCR shedding in DU-145 cells are *mediated* by [MEK/ERK 1/2] , JNK , and p38 MAPK signalling cascades . Positive_regulation MAPK3 TNF 21336587 2457991 Effects of preconditioning with sevoflurane on induced permeability and *activation* of p38 [MAPK] in rat pulmonary microvascular endothelial cells . Positive_regulation MAPK3 TNF 21350193 2420597 stimulated a transient phosphorylation of JNK1/2 and ERK1/2 at 15 min , which returned to basal by 60 min and remained low for 4 h. CPT increased JNK1/2 activity between 3 and 4 h . TNF + CPT *caused* a sustained and robust JNK1/2 and [ERK1/2] phosphorylation by 2 h , which remained high at 4 h , suggesting involvement of MEKK4/7 and MEK1 , respectively . Positive_regulation MAPK3 TNF 21422246 2416770 Interestingly , all PHA-L ( high ) DCs displayed a strongly reduced responsiveness to *induced* [p38-MAPK] activation compared with PHA-L ( low ) DCs , indicating differences in PHA-L binding capacities between DCs with different inflammatory properties . Positive_regulation MAPK3 TNF 21422246 2416784 Moreover , hybrid-type , but not complex-type , N-glycans are required for *induced* [p38-MAPK] activation and subsequent phenotypic maturation of BMDCs ( MHC-II , CD86 , CCR7 upregulation ) . Positive_regulation MAPK3 TNF 21493783 2499815 Moreover , *led* to up-regulation of the [ERK1/ERK2] and p38 MAPKs pathways , with only the latter being sensitive to pretreatment with the glucocorticoid dexamethasone . Positive_regulation MAPK3 TNF 21520062 2423123 Here , we report that *induced* cPLA(2) protein and mRNA expression , PGE ( 2 ) production , and phosphorylation of p42/p44 MAPK , p38 [MAPK] , and JNK1/2 , which were attenuated by pretreatment with a ROS scavenger [ N-acetyl-L-cysteine , ( NAC ) ] and the inhibitors of NADPH oxidase [ apocynin (APO) and diphenyleneiodonium chloride ( DPI ) ] , MEK1/2 ( U0126 ) , p38 MAPK ( SB202190 ) , and JNK1/2 ( SP600125 ) or transfection with siRNA of Nox2 , p47(phox) , MEK1 , p42 , p38 , or JNK2 . Positive_regulation MAPK3 TNF 21545687 2554382 significantly *induced* phosphorylation of p38 [MAPK] , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation MAPK3 TNF 21554104 2429333 Because *causes* phosphorylation of [ERK1/2] , we investigated whether histamine acted via secretion of TNF-a to affect ERK1/2 phosphorylation . Positive_regulation MAPK3 TNF 21852236 2490737 GPx-1 deficiency prolonged *induced* I?Ba degradation and activation of [ERK1/2] and JNK . Positive_regulation MAPK3 TNF 21894146 2510876 Vehicle and untreated NTN exhibited heavy proteinuria and glomerular thrombosis at 24 h with P-selectin and fibrin immunostaining within capillaries , glomerular macrophage and T cell infiltration , *activation* of JNK and p38 [MAPK] signalling , and upregulation of glomerular mRNA levels of pro-inflammatory molecules ( , NOS2 , MMP-12 and CCL2 ) . Positive_regulation MAPK3 TNF 22002864 2526329 These results suggest that H ( 2 ) O ( 2 ) -induced secretion of *increases* apoptosis of cardiac myocytes through ROS dependent activation of p38 [MAPK] . Positive_regulation MAPK3 TNF 22112961 2574779 This effect was associated with the reduction in *induced* [ERK1/2] phosphorylation in human neutrophils . Positive_regulation MAPK3 TNF 22227193 2544578 Casuarinin significantly inhibited induced *activation* of NF-?B , STAT1 , and p38 [MAPK] . Positive_regulation MAPK3 TNF 22230399 2519478 KMUP-1 inhibited *induced* iNOS and U46619 induced PDE-5A and phospho-p38 [MAPK] in normoxia , confirming its anti-proinflammatory action . Positive_regulation MAPK3 TNF 22250084 2551213 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Positive_regulation MAPK3 TNF 22343222 2617820 Using immunohistological techniques , we showed a higher epithelial expression of , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator [protein-1/mitogen activated protein kinase] signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation MAPK3 TNF 22525504 2522574 *up-regulated* the phosphorylation levels of p38 [MAPK] and increased the translocation of NF-kB p65 protein into the nucleus , also proved by immunofluorescence staining . Positive_regulation MAPK3 TNF 22526394 2595915 also *increased* the production of inducible nitric oxide synthase (iNOS) , nitric oxide ( NO ) , and intercellular adhesion molecule 1 ( ICAM-1 ) through activation of p38 [mitogen activated protein kinase (MAPK)] from HT-29 cells . Positive_regulation MAPK3 TNF 22561121 2608687 Zaprinast was found to activate [ERK1/2] , p38 MAPK , JNK , NF?B , and PI3K/Akt , and subsequently , *induce* the mRNA expressions of IL-1a , IL-1ß , , CCL2 , CCL4 , CXCL1 , CXCL2 , and CD14 . Positive_regulation MAPK3 TNF 22773691 2659904 induced *activation* of p38 [MAPK] and NF-?B was attenuated by miR-140-3p mimic . Positive_regulation MAPK3 TNF 22819264 2646097 CORM-2 inhibited induced *activation* of p38 [MAPK] , ERK1/2 , JNK , and NF-?B signaling pathways in HUVECs . Positive_regulation MAPK3 TNF 22947346 2678663 *induced* phosphorylated p38 [mitogen activated protein kinase] levels were increased in ASMCs from patients with severe asthma compared with those from patients with nonsevere asthma and nonasthmatic subjects , whereas TNF-a induced phosphorylated c-Jun N-terminal kinase and phosphorylated extracellular signal related kinase levels were increased in all asthmatic groups . Positive_regulation MAPK3 TNF 22988345 2674357 The EGF receptor and HER2 participate in dependent [MAPK] *activation* and IL-8 secretion in intestinal epithelial cells . Positive_regulation MAPK3 TNF 22988345 2674385 As the epidermal growth factor receptor (EGFR) is a known transducer of proliferative signals and a potent activator of MAPKs , we hypothesized that the EGFR participates in dependent [MAPK] *activation* and IL-8 secretion by intestinal epithelial cells ( IECs ) . Positive_regulation MAPK3 TNF 23071098 2720909 Mixed-effects modeling analysis of our data was vital for ascertaining that IL-1a and TGF-a treatment increased the activities of more pathways than IL-6 and TNF-a and that TGF-a and *increased* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phospho-protein levels in a synergistic manner . Positive_regulation MAPK3 TNF 23142559 2722788 Western blot analysis revealed that pilocarpine and physostigmine enhanced the *induced* phosphorylation of ERK1/2 and p38 [MAPK] and the degradation of I?Ba . Positive_regulation MAPK3 TNF 23159491 2729679 Finally , we demonstrate that the transmembrane forms of wild-type and palmitoylation-defective interact differently with TNFR1 and *regulate* NF?B activity , [Erk1/2] phosphorylation and interleukin-6 synthesis differently , strongly suggesting that palmitoylation of TNF is involved in the regulation of TNFR1 signalling . Positive_regulation MAPK3 TNF 23333920 2758386 Interestingly , IL-27 promoted the basal and enhanced *induced* phosphorylation of p38 [MAPK] and Akt , but not I?Ba . Positive_regulation MAPK3 TNF 23353699 2754242 We further demonstrated that markedly *stimulated* p38 [MAPK] , p42/p44 MAPK , and JNK1/2 phosphorylation via a c-Src/EGFR , PDGFR/PI3K/Akt pathway . Positive_regulation MAPK3 TNF 23354775 2770499 p38a [mitogen activated protein kinases (MAPK)] may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , , interleukin-1ß , and oxidative stress . Positive_regulation MAPK3 TNF 23664593 2838385 sFGL2 secretion by CD4 ( + ) T cells can be *induced* with and IFN-? stimulation through [MAPK] signaling in renal allograft AR . Positive_regulation MAPK3 TNF 23699531 2792340 Recombinant PGRN or transfection of a cDNA encoding PGRN did not antagonize dependent NF?B , Akt , and [Erk1/2] pathway *activation* ; Positive_regulation MAPK3 TNF 23861542 2817239 ROCK1 dependent release of myosin was necessary for the dependent recruitment of TRAF2 to p75 and for p75-specific *activation* of NF-?B and [MAPK] signaling . Positive_regulation MAPK3 TNF 23884101 2821470 Furthermore , P. vulgaris extract suppressed *induced* phosphorylation of p38 [mitogen activated protein kinase (MAPK)] and extracellular signal regulated kinase ( ERK ) . Positive_regulation MAPK3 TNF 23933846 2902045 Treatment with honokiol also reduced *induced* phosphorylation of p38 , [extracellular signal regulated kinase 1/2] , and c-Jun N-terminal kinase . Positive_regulation MAPK3 TNF 23935096 2840769 In contrast , loss of SK1 prevented *induced* phosphorylation of p38 [MAPK] , and inhibition of p38 MAPK , like SK1 knockdown , also potentiates RANTES induction . Positive_regulation MAPK3 TNF 24039713 2842344 *induced* nuclear localization of phosphorylated [ERK 1/2] ( p-ERK 1/2 ) correlated with increased apoptosis in TR1- and Trx1-deficient cells , suggesting a pro-apoptotic role for nuclear p-ERK 1/2 in TNF-a induced apoptosis . Positive_regulation MAPK3 TNF 24039713 2842347 In addition , phosphoinositide 3-kinase (PI3K) inhibition dramatically reduced *stimulated* apoptosis and nuclear localization of [p-ERK 1/2] . Positive_regulation MAPK3 TNF 24069158 2846995 We showed that markedly *stimulated* p42/p44 MAPK , p38 [MAPK] , and JNK1/2 phosphorylation which were attenuated by their respective inhibitors . Positive_regulation MAPK3 TNF 24080497 2902541 Consistently , DUSP1 promotes apoptosis and decreases NF-?B activity in cells in which p38 [MAPK] is *induced* by treatment . Positive_regulation MAPK3 TNF 24089494 2848152 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed receptor 1 and *requires* activation of p38 [MAPK] , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation MAPK3 TNF 24098442 2852230 *induced* activation of [extracellular signal regulated kinase 1/2] ( ERK1/2 ) was reduced by EFNB1-overexpression . Positive_regulation MAPK3 TNF 24361597 2911247 We further demonstrated that *stimulated* ERK1/2 , p38 [MAPK] , and JNK1/2 phosphorylation via a c-Src dependent PDGFR/PI3K/Akt pathway . Positive_regulation MAPK3 TNF 24378531 2911775 TRAF2 has been previously reported to be required for *induced* activation of p38 [MAPK] . Positive_regulation MAPK3 TNF 24441870 2922935 We showed that markedly *stimulated* Jak2 , PDGFR , Akt , and p42/p44 [MAPK] phosphorylation , which were attenuated by their respective inhibitors . Positive_regulation MAPK3 TNF 24441870 2922953 In addition , *induced* p42/p44 [MAPK] phosphorylation was reduced by AG1296 or LY294002 . Positive_regulation MAPK3 TNF 24441870 2922989 On the other hand , could *induce* Akt and p42/p44 [MAPK] translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation MAPK3 TNF 24446489 2912940 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Positive_regulation MAPK3 TNF 24489443 2884794 Finally , by investigating the intracellular pathways involved in promoting the VEC release of cytokines/chemokines , which are targeted by natural anti-inflammatory compounds , we documented that aLipoic acid significantly counteracted *induced* NF-?B and [p38/MAPK] activation while the effects of Ginkgo biloba appeared to be predominantly mediated by Akt . Positive_regulation MAPK3 TNF 24507356 2914244 The results showed that the treatment of macrophages with CS3 could not only increase the nitric oxide ( NO ) release and the cytokines , IL-6 and IL-1ß production significantly , but also *enhance* the inducible NOS (iNOS) expression , NF-?Bp65 nuclear translocation , [Erk1/2] and SAPK/JNK phosphorylation . Positive_regulation MAPK3 TNF 24750790 2936575 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas and NO production *required* all three [MAPK] . Positive_regulation MAPK3 TNF 7689564 225766 *induced* activation and increased tyrosine phosphorylation of [mitogen activated protein (MAP) kinase] in human fibroblasts . Positive_regulation MAPK3 TNF 7689564 225779 *induced* activation of [MAPK] was demonstrated by its enhanced ability to phosphorylate myelin basic protein in vitro and by a characteristic shift in the electrophoretic mobility of MAPK proteins . Positive_regulation MAPK3 TNF 7722327 301759 *induces* tyrosine phosphorylation of [mitogen activated protein kinase] in adherent human neutrophils . Positive_regulation MAPK3 TNF 7722327 301785 PMN pretreatment with genistein , a tyrosine kinase inhibitor , inhibited the *induced* increase in tyrosine phosphorylation and [MAPK] activity . Positive_regulation MAPK3 TNF 7726846 302076 Since we recently found that stimulation of neutrophils does not *increase* the tyrosine phosphorylation or activation of the p42erk2 and [p44erk1] mitogen activated protein kinases ( MAPKs ) , the present studies demonstrate the involvement of a MAPK independent pathway in the phosphorylation and activation of cPLA2 . Positive_regulation MAPK3 TNF 8626494 360278 Inhibition of *induced* p42/p44 [mitogen activated protein kinase] activation by sodium salicylate . Positive_regulation MAPK3 TNF 8626494 360292 *activates* both p42 and p44 [mitogen activated protein kinases (MAPK)] in human FS-4 fibroblasts , cells for which TNF is mitogenic . Positive_regulation MAPK3 TNF 8626494 360305 We now show that *activates* p42 [MAPK] in two cell lines whose growth is inhibited by TNF . Positive_regulation MAPK3 TNF 8626494 360320 We now show that neither phorbol ester-sensitive protein kinase C nor Gialpha link TNF to p42/p44 MAPK activation , because pretreatment of FS-4 cells with phorbol ester to down-regulate protein kinase C or pretreatment with pertussis toxin to block Gialpha does not inhibit p42/p44 [MAPK] *activation* by . Positive_regulation MAPK3 TNF 8626494 360344 To further analyze MAPK activation in FS-4 cells , we compared p42/p44 [MAPK] *activation* by and epidermal growth factor (EGF) . Positive_regulation MAPK3 TNF 8626494 360365 Elucidation of the mechanism whereby sodium salicylate blocks induced p42/p44 [MAPK] *activation* may help to clarify TNF activated signaling pathways . Positive_regulation MAPK3 TNF 8662702 367184 additionally *caused* rapid p38 and JNK-1 [mitogen activated protein kinase] activation and efficient NF-kappaB translocation , which could not be achieved even by high levels of ceramide . Positive_regulation MAPK3 TNF 9106254 424417 The increases in [MAPK] *induced* by and IL-1 were similar to the increases induced by PMA and PDGF-AB . Positive_regulation MAPK3 TNF 9106254 424443 Our findings indicate that and IL-1 activate parallel signal transduction pathways in human neuroma fibroblasts , and that they are relatively stronger *activators* of [MAPK] than of SAPK . Positive_regulation MAPK3 TNF 9315666 456102 , an inhibitor of insulin stimulated adipogenesis , *activated* [MAPK] in 3T3-L1 cells . Positive_regulation MAPK3 TNF 9439626 482871 *increased* ERK1 and ERK2 [MAPK] phosphorylation . Positive_regulation MAPK3 TNF 9439626 482897 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic effect of *requires* protein tyrosine phosphorylation and [MAPK] activation . Positive_regulation MAPK3 TNF 9593119 505487 The CAZ released endotoxin was similar to purified LPS with respect to the following biological activities in LPS-responsive C3H/HeN mice and LPS-hyporesponsive C3H/HeJ mice : lethal toxicity in GalN sensitized mice , in vitro induction of and NO production by macrophages , and [mitogen activated protein kinase] *activation* in macrophages . Positive_regulation MAPK3 TNF 9624172 511401 These results show that IL-1beta- or induced LDL receptor expression *requires* [ERK-1/2] activation , that the p38 ( MAPK ) pathway negatively regulates LDL receptor expression , and that sterols inhibit induction at a point downstream of ERK-1/2 in HepG2 cells . Positive_regulation MAPK3 TNF 9766635 538512 Our data suggest that and GM-CSF *activate* ERKs and p38 [MAPK] by different signal transduction pathways . Positive_regulation MAPK3 TNF 9770326 538804 Furthermore , *induction* of p42/p44 ERK and [p38-MAPK] phosphorylation , c-jun kinase activation , and IkappaBalpha degradation were normal . Positive_regulation MAPK3 TNF 9883899 558210 *Activation* of p42/p44 [mitogen activated protein kinases (MAPK)] and p38 MAPK by is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation MAPK3 TNF 9883899 558225 Here , we demonstrate that is *sufficient* to activate p42/p44 MAPK and p38 [MAPK] . Positive_regulation MAPK3 TNF 9930718 588839 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Positive_regulation MAPK3 TNF 9931102 588906 ( 100 U/mL ) transiently *activated* [MAPK] with a maximal induction 10 minutes after stimulation that returned to baseline levels by 2 hours after treatment . Positive_regulation MAPK3 TNF 9931102 588919 PD98059 also blocked *stimulated* [MAPK] activation in a concentration dependent manner , which is consistent with its inhibition of TNF-alpha directed migration . Positive_regulation MAPK3 TNF 9931102 588932 To identify which TNF-alpha receptor is involved in *induced* [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Positive_regulation MAPK3 TNF 9931102 588958 VSMC express both receptors , but *induced* [MAPK] activation was inhibited only by the TNF-R1 antibody . Positive_regulation MAPK3 TNF 9931102 588984 Both TRO and RSG inhibited migration , but neither attenuated induced [MAPK] *activation* , indicating that their antimigration activity was exerted downstream of MAPK . Positive_regulation MAPK3 TNFSF10 11278665 811104 Activation of the FasR , TNF-R1 , and , respectively , rapidly *induced* subsequent [ERK1/2] activation , an event independent from caspase activity . Positive_regulation MAPK3 TNFSF10 12969966 1185573 Among the intracellular pathways investigated , significantly *stimulated* the extracellular signal regulated kinase 1/2 ( ERK1/2 ) but not the [p38/mitogen activated protein kinase (MAPK)] or the c-Jun NH2-terminal kinase (JNK) pathway . Positive_regulation MAPK3 TNFSF10 15289937 1278544 Western blot analysis consistently showed that *induced* a significant activation of [ERK1/2] , and a much weaker phosphorylation of Akt , while it did not affect the p38/MAPK pathway . Positive_regulation MAPK3 TNFSF10 16305985 1486395 Here we show that *activated* [ERK1/2] through a tyrosine kinase dependent pathway , subsequently elevated anti-apoptotic Bcl-2 protein levels . Positive_regulation MAPK3 TNFSF10 17595512 1764780 *induced* the phosphorylation of [ERK1/2] , but not of Akt . Positive_regulation MAPK3 TNFSF10 18239851 1877042 Inhibition of MEK1 eliminated both *induced* [ERK1/2] activation and cell proliferation . Positive_regulation MAPK3 TNFSF10 18239851 1877043 In addition , siRNA inhibition of c-FLIP expression eliminates *induced* [ERK1/2] activation and proliferation . Positive_regulation MAPK3 TNFSF10 18239851 1877044 Furthermore , overexpression of c-FLIP ( L ) potentiates *induced* [ERK1/2] activation and proliferation of resistant glioma cells . Positive_regulation MAPK3 TNFSF10 18239851 1877045 Our results have shown for the first time that *induced* [ERK1/2] activation and proliferation of TRAIL-resistant human glioma cells is dependent upon the expression of the long form of the caspase-8 inhibitor c-FLIP ( L ) . Positive_regulation MAPK3 TNFSF10 20951126 2364963 Taken together , this study provided first evidence demonstrating that , TNF-a- , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK3 TNFSF10 21152872 2373395 Taken together , we show herein that the upstream molecule of the *induced* [MAPK] activation is MEKK , as opposed to ASK1 , via the mediation of its signal through JNK/p38 in a caspase-8 dependent manner . Positive_regulation MAPK3 TNFSF10 24299309 2904815 In addition to activate the extrinsic and intrinsic apoptotic pathway , also *triggered* the activation of [ERK1/2] . Positive_regulation MAPK4 ADRB2 11018034 752792 induced p38 [MAPK] *activation* is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes . Positive_regulation MAPK4 ADRB2 12509508 1038746 beta-Arrestin 1 is required for internalization and [mitogen activated protein (MAP) kinase] *activation* by the . Positive_regulation MAPK4 ADRB2 19047375 2023486 Hematopoietic protein tyrosine phosphatase mediates *induced* regulation of p38 [mitogen activated protein kinase] in B lymphocytes . Positive_regulation MAPK4 ADRB2 9038193 415367 In the present work , we report that stimulation of the A2A-adenosine receptor and of the *activates* [mitogen activated protein kinase] ( MAP kinase ) in human endothelial cells based on the following criteria : adenosine analogues and beta-adrenergic agonists cause an ( i ) increase in tyrosine phosphorylation of the p42 isoform and to a lesser extent of the p44 isoform of MAP kinase and ( ii ) stimulate the phosphorylation of myelin basic protein by MAP kinase; (iii) this is accompanied by a redistribution of the enzyme to the perinuclear region . Positive_regulation MAPK4 ADRB2 9363896 462910 We show that in HEK293 cells , *stimulation* of [mitogen activated protein (MAP) kinase] by the is mediated by the betagamma subunits of pertussis-toxin-sensitive G proteins through a pathway involving the non-receptor tyrosine kinase c-Src and the G protein Ras . Positive_regulation MAPK4 ALOX5 11807011 903510 In contrast , stress induced product formation and translocation of <5-LO> , as well as *activation* of p38 [MAPK] , occurred also after Ca ( ++ ) depletion . Positive_regulation MAPK4 ALOX5 21200133 2391692 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Positive_regulation MAPK4 ANGPT1 12039842 954283 Accordingly , ephrinB2 inhibited VEGF- and *induced* [Ras-MAPK] activities , whereas ephrinB2 did not alter VEGF induced Flk phosphorylation or Ang1 induced Tie2 phosphorylation . Positive_regulation MAPK4 ANGPT1 12213710 985647 Both VEGF and *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 [MAPK] . Positive_regulation MAPK4 ANGPT1 12213726 985717 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of and Ang-2 as well as the *activation* of [MAPK] , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation MAPK4 ANGPT1 16061664 1439071 *activated* [mitogen activated protein kinase (MAPK)] and phosphoinositide 3-kinase (PI3K) in IBE cells and HUVECs . Positive_regulation MAPK4 ANGPT1 16679392 1612155 Pretreatment with either DPI or apocynin also significantly attenuated *induced* Akt and p44/42 [MAPK] phosphorylation . Positive_regulation MAPK4 ANGPT1 16679392 1612171 Using mouse heart microvascular endothelial cells from wild-type ( WT ) mice and mice deficient in the p47(phox) component of NADPH oxidase ( p47 ( phox-/- ) ) , we found that although *stimulated* intracellular ROS , Akt and p42/44 [MAPK] phosphorylation , and cell migration in WT cells , the responses were strikingly suppressed in cells from the p47 ( phox-/- ) mice . Positive_regulation MAPK4 ANGPT1 20072135 2235289 *promoted* skin cell metabolism/viability , adhesion , and akt and [MAPK] ( p42/44 ) activations . Positive_regulation MAPK4 ANO1 22564524 2619164 *induces* [MAPK] and contributes directly to tumorigenesis and cancer progression . Positive_regulation MAPK4 CAPN8 21543591 2424145 Downstream , an Aß-mediated rise in p38 [mitogen activated protein kinase (MAPK)] activation was followed by downregulation of cAMP response element binding protein , and LTP impairment was *prevented* by inhibitors of p38 MAPK or . Positive_regulation MAPK4 CAPN8 24416390 2901013 Treatment with glutamate leads to early activation of NMDAR , which in turn leads to mediated cleavage of striatal enriched protein tyrosine phosphatase ( STEP ) and subsequent *activation* of p38 [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK4 CCL17 23711854 2792903 IL-33 induced the production of thymus and activation regulated and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 [MAPK] . Positive_regulation MAPK4 CCND1 11004713 735020 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping [ERK-MAPK] activation and c-Fos and *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation MAPK4 CCND1 12654183 1072986 [MAPK] may *induce* overexpression of protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation MAPK4 CCND1 15634644 1349556 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 [mitogen activated protein kinase] , and down-regulation of . Positive_regulation MAPK4 CCND1 16522728 1531460 We conclude that incretin induced beta-cell replication is dependent on cAMP/PKA , p42 [MAPK] and PI3K activities , which may *involve* transcriptional induction of . Positive_regulation MAPK4 CCND1 9537433 497564 Furthermore , in 25 of 26 cases of HCC which genomic DNA was available , 22 cases without genomic DNA amplification exhibited positive correlation , not only between protein expression of c-Fos and , but also between [MAPK/ERK] *activation* and cyclin D1 expression . Positive_regulation MAPK4 CD14 15625444 1349239 LPS interacts with the cell surface receptor , which generates transmembrane signals through Toll-like protein 4 *leading* to [mitogen activated protein kinase (MAPK)] p38 activation , cytokine synthesis , PMN beta2-integrin expression and oxidative burst . Positive_regulation MAPK4 CHI3L1 23755018 2797730 In addition , *induces* [FAK-MAPK] signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation MAPK4 CHI3L1 23972995 2836242 We also demonstrate that *activates* macrophage [mitogen activated protein kinase] , protein kinase B/AKT , and Wnt/ß-catenin signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation MAPK4 CLU 23051594 2702821 FOXL2 directly stimulates the Clu gene promoter , and we show that PTTG triggers ataxia telangiectasia mutated [kinase/IGF-I/p38MAPK] DNA damage/chromosomal instability signaling , which in turn also *induces* expression . Positive_regulation MAPK4 CTGF 11732999 885265 *induces* chondrocyte differentiation through a p38 [mitogen activated protein kinase] ( p38MAPK ) , and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase ( ERK ) . Positive_regulation MAPK4 CTGF 11732999 885279 In the proliferation phase , *induced* a approximately fivefold increase in the phosphorylation of p44/42 [MAPK/ERK] and a approximately twofold increase in that of p38 MAPK in an in vivo kinase assay . Positive_regulation MAPK4 CTGF 12218048 1012165 The inhibition of *induced* p42/44 [MAPK] or phosphatidylinositol 3-kinase (PI3K)/protein kinase B pathway activities abrogated the induction of fibronectin expression . Positive_regulation MAPK4 CTGF 16408113 1513480 *enhanced* the mRNA expression and protein release of fractalkine , MCP-1 , and RANTES , the expression of phospho ( P ) -p42/44 [mitogen activated protein kinase (MAPK)] , P-phosphoinositide 3-kinase (PI3-K) , P-Akt , and activity of nuclear factor-kappaB (NF-kappaB) in mesangial cells . Positive_regulation MAPK4 CTGF 16408113 1513514 P-p42/44 MAPK blockade inhibited the *induced* expression of P-p42/44 [MAPK] but not NF-kappaB , and partially decreased the levels of the above chemokines in supernatants . Positive_regulation MAPK4 CTGF 16522717 1531328 ( 3 ) *stimulated* dose dependent HSC adhesion and activity of p42/p44 [mitogen activated protein kinase] , the latter of which was antagonized by blocking the activity of focal adhesion kinase . Positive_regulation MAPK4 CTGF 16938382 1654127 No single module , but a mixture of the 4 modules provoked a significant activation of p38 [MAPK] in HCS-2/8 cells , which was *activated* by the full-length . Positive_regulation MAPK4 CTGF 19038999 2023089 Interestingly , CCN2-BMP-2 did not affect the *induced* phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Positive_regulation MAPK4 EDN2 12193071 980940 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Positive_regulation MAPK4 EDN2 12475899 1037778 *induced* a rapid phosphorylation of the [mitogen activated protein kinase (MAPK)/ERK] and increased collagen I gene activity in freshly isolated aortas . Positive_regulation MAPK4 EDN2 1280103 203045 rapidly *stimulates* [mitogen activated protein kinase] activity in rat mesangial cells . Positive_regulation MAPK4 EDN2 12855582 1149896 also *induced* the activation of p42/44 [mitogen activated protein kinase (MAPK)] in DCs . Positive_regulation MAPK4 EDN2 7509933 241612 *stimulates* [mitogen activated protein kinase] p42 activity through the phosphorylation of the kinase in rat mesangial cells . Positive_regulation MAPK4 EDN2 7849246 286736 *stimulates* [mitogen activated protein kinase] activity in mesangial cells through ETA . Positive_regulation MAPK4 EDN2 7943276 276403 has been shown to *activate* [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK4 EDN2 8836145 386177 In bovine airway smooth-muscle cells platelet derived growth factor ( PDGF ) and ( Et-1 ) *stimulate* sustained and comparable activation of [mitogen activated protein kinase] ( MAP kinase ) but display very different mitogenic efficacies , with PDGF inducing 50 times more DNA synthesis than Et-1 . Positive_regulation MAPK4 EFNB1 15502157 1347563 Further downstream of the signaling pathway , stimulation *led* to increased LAT ( linker for activation of T-cells ) phosphorylation and p44/42 and p38 [MAPK] activation . Positive_regulation MAPK4 EPHB2 10601128 574213 Tumor necrosis factor-alpha (TNF-alpha) alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only . Positive_regulation MAPK4 EPHB2 10872747 707028 Pre-treatment of the cells with PD98059 , a selective pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation MAPK4 EPHB2 11083274 750494 Tumor necrosis factor alpha , interleukin-1 (IL-1) , and IL-6 were the major inducers of , JNK , and p38 [MAPK] *activation* in cultured human synovial cells . Positive_regulation MAPK4 EPHB2 12386816 999766 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 [MAPK] and a biphasic *activation* of . Positive_regulation MAPK4 EPHB2 12403788 1036185 SB203580 , a p38 [MAPK] *inhibitor* , and PD98059 , an inhibitor , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation MAPK4 EPHB2 12486127 1056311 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain *had* little effect on basal Erk [MAPK] activation . Positive_regulation MAPK4 EPHB2 12511425 1070740 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation MAPK4 EPHB2 12801927 1120235 GE2 stimulation *induced* phosphorylation , whereas it did not alter the phosphorylation of c-Jun N-terminal kinase or p38 [MAPK] . Positive_regulation MAPK4 EPHB2 12832293 1105580 Exposure to E. coli DNA resulted in phosphorylation of ERK 1/2 [MAPK] and inhibitors of activity ( PD98059 , UO126 ) significantly *reduced* the evoked IL-8 production . Positive_regulation MAPK4 EPHB2 12878192 1115522 ( 2 ) the *activation* of JNK and p38 [MAPK] but not in embryonic fibroblasts ( MEFs ) derived from ASK1 knockout mice ( ASK1 ( -/- ) MEFs ) was depressed compared to MEFs derived from wild type mice ( ASK1 ( +/+ ) MEFs ) ; Positive_regulation MAPK4 EPHB2 14973553 1212693 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen activated protein kinase (MAPK)] signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation MAPK4 EPHB2 14998726 1216733 Furthermore , we found that PD98059 , an pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation MAPK4 EPHB2 15659876 1350313 The anabolic effect of TNF-alpha was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an . Positive_regulation MAPK4 EPHB2 16038626 1437427 SF significantly prevented Abeta induced increases in IL-1beta and p38 [MAPK] *activation* and also Abeta induced changes in and phospho-Akt/PKB expression levels . Positive_regulation MAPK4 EPHB2 17056059 1649530 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Positive_regulation MAPK4 EPHB2 17403539 1735937 Trauma-hemorrhage increased the production of IL-6 , IL-10 , IL-12 and TNF-alpha enhanced the expression of TLR4 , MyD88 as well as the *activation* of [MAPK] proteins ( p38 , and JNK ) in epidermal keratinocytes . Positive_regulation MAPK4 EPHB2 17416211 1777903 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK4 EPHB2 17464174 1731748 The mRNA and surface protein up-regulation of CCR1 and CCR2 in 9CRA stimulated cells were weakly blocked by the pretreatment of SB202190 , a p38 [MAPK] *inhibitor* , and PD98059 , an upstream inhibitor . Positive_regulation MAPK4 EPHB2 18164124 1869613 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 [MAPK] , but not by the *activation* of JNK , , and NF-kappaB pathway . Positive_regulation MAPK4 EPHB2 18266967 2000318 VEGF induced activation of p42 also *led* to the nuclear translocation of [MAPK/ERK1/2] . Positive_regulation MAPK4 EPHB2 18285354 1885409 Pre-treatment with the [MAPK] *inhibitors* SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( inhibitor ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation MAPK4 EPHB2 18338254 1938061 Interestingly , inhibition of by U0126 completely *prevented* artepillin C-induced p38 [MAPK] phosphorylation of PC12m3 cells . Positive_regulation MAPK4 EPHB2 18520049 1918676 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of , rather than by the *activation* of p38 [MAPK] , in the spinal cord . Positive_regulation MAPK4 EPHB2 18982426 2105750 These inhibitory effects were partially inhibited by SB203580 , a specific *inhibitor* of p38 [MAPK] , but not by PD98059 , a specific inhibitors of extracellular signal regulated kinase ( ) , and SP600125 , a specific inhibitor of c-Jun-N-terminal kinase (JNK) . Positive_regulation MAPK4 EPHB2 19189219 2113965 Moreover , EM1 treatment resulted in less activation of p38 [MAPK] and more *activation* of signaling in lipopolysaccharide stimulated DCs . Positive_regulation MAPK4 EPHB2 19276187 2051421 Treatment of cells with sphingosine induced suppression of and *activation* of p38 [MAPK] . Positive_regulation MAPK4 EPHB2 19429670 2106924 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either inhibitor , [p38MAPK] *inhibitor* or NF-kappaB inhibitor . Positive_regulation MAPK4 EPHB2 19522739 2103144 Treatment with [MAPK] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation MAPK4 EPHB2 19672126 2168073 A scratch wound assay of healing rates in SV40 immortalized human corneal epithelial cell line ( HCEC ) evaluated the relative contributions by p38 and and JNK [MAPK] signaling *activation* to wound healing . Positive_regulation MAPK4 EPHB2 20025124 2175516 Prior treatment of the cells with PD98059 , an kinase inhibitor or SB203580 , a [p38MAPK] *inhibitor* , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation MAPK4 EPHB2 20554538 2327625 The HNE enhanced Sp1 and NF-?B activities were attenuated by SB203580 , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , and PD98059 , an extracellular signal regulated kinase ( ) inhibitor , respectively . Positive_regulation MAPK4 EPHB2 21126656 2355802 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 [mitogen activated protein kinase] , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by . Positive_regulation MAPK4 EPHB2 21311676 2360037 Treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation MAPK4 EPHB2 21488184 2417976 Dexmedetomidine induced phosphorylation of JNK and p38 [MAPK] in rat aortic SMCs , but did not *induce* phosphorylation of . Positive_regulation MAPK4 EPHB2 21586573 2449669 Incubation of T cells with ESAT-6 induced phosphorylation and increased functional p38 [MAPK] activity , but not *activation* of or JNK . Positive_regulation MAPK4 EPHB2 21599960 2445732 In the present studies , induction of central sensitization as indicated by spinal dorsal horn [MAPK] *activation* , specifically and p38 phosphorylation , was assessed in the MIA-OA model . Positive_regulation MAPK4 EPHB2 23394443 2713242 When compared to hamsters bearing tumors that remained on the control diet , the buccal pouches of hamsters bearing tumors receiving turmeric showed the following results : ( 1 ) decreased cell proliferation ( diminished PCNA , cyclin D1 , and Bcl-2 ) and PCNA labelling index , ( 2 ) enhanced apoptosis ( increased Bax , caspase-3 , caspase-9 , and cytochrome c , and decreased survivin ) and apoptotic index , ( 3 ) decreased inflammation ( decreased Cox-2 ) , and ( 4 ) decreased [MAPK] *activation* ( and p-p38 ) . Positive_regulation MAPK4 EPHB2 23892041 2830338 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three [MAPK] *inhibitors* ( inhibitor PD98059 , JNK inhibitor SP600125 and p38 inhibitor SB203580 ) . Positive_regulation MAPK4 EPHB2 23914844 2840574 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 [MAPK] and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of , JNK , NF-?B . Positive_regulation MAPK4 EPHB2 23917355 2826039 Inhibition of Akt or activity *reduced* phosphorylation of STAT1 in Colon26L5-CUG2 cells whereas inhibition of p38 [MAPK] did not significantly decrease levels of STAT1 phosphorylation , indicating that cell proliferation signals may be involved in CUG2 mediated activation of STAT1 . Positive_regulation MAPK4 EPHB2 24225419 2897498 Therefore , by using the [MAPK] *inhibitors* SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific inhibitor ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation MAPK4 EPHB2 24297112 2894225 Following treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation MAPK4 F2R 16052512 1460028 The p38 and ERK1/2 [MAPK] signaling cascades were also *activated* by stimulation , whereas the SAPK/JNK pathway was unaffected . Positive_regulation MAPK4 F2R 16467309 1548159 and PAR-2 stimulation rapidly *activated* both ERK1/2 and [p38MAPK] , and pharmacological blockade of MEK with either PD98059 or U0126 or of p38MAPK by SB203580 or SB202190 strongly inhibited thrombin- and SLIGKV induced COX-2 expression and 6-keto-PGF1alpha formation . Positive_regulation MAPK4 F2R 21252088 2402888 In the present study , we show that FVIIa , upon binding to EPCR on endothelial cells , activates endogenous protease activated receptor-1 (PAR1) and induces mediated p44/42 [mitogen activated protein kinase (MAPK)] *activation* . Positive_regulation MAPK4 F2R 24052258 2867019 However , the distinct non-canonical tethered ligands unmasked by neutrophil elastase and proteinase-3 , as well as synthetic peptides with sequences derived from these novel exposed tethered ligands , selectively stimulated mediated [mitogen activated protein kinase] *activation* . Positive_regulation MAPK4 F2R 8635212 357956 These results support the notion that the *activates* [MAPK] through PKC dependent pathways and that the incremental activation of MAPK by TRAP over that induced by thrombin is the consequence of enhanced activation through the PKC limb of the phosphoinositide lipid pathway . Positive_regulation MAPK4 FAS 14576831 1156608 A more physiological inhibitor , the intracellular PP2A inhibitor protein I2 ( PP2A ) , protected transfected HeLa cells in a similar way from mediated apoptosis and induced *activation* of [MAPK] in I2 ( PP2A ) transfected cells . Positive_regulation MAPK4 FAS 15280387 1302535 We further demonstrate that this pro-apoptotic effect of CO was independent of reactive oxygen species production and involved inhibition in *induced* activation of the pro-survival ERK [MAPK] . Positive_regulation MAPK4 FAS 16507991 1529641 Here we show that binding of Fas ligand to *activates* p38 [MAPK] in CD8+ T cells and that activation of this pathway is required for Fas mediated CD8+ T-cell death . Positive_regulation MAPK4 FAS 19417161 2179813 GST-MDA-7 killing was , in parallel , dependent on inactivation of extracellular signal regulated kinase 1/2 and on *induced* p38 [mitogen activated protein kinase] and c-jun NH ( 2 ) -terminal kinase-1/2 signaling . Positive_regulation MAPK4 FAS 21613257 2454279 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Positive_regulation MAPK4 FAS 21975294 2492846 Caspase-8 activity has an essential role in *mediated* [MAPK] activation . Positive_regulation MAPK4 FAS 8977313 403349 IFN-alpha2 did not alter the *induced* activity of [Mitogen activated protein kinase (MAPK)] 1 and did not inhibit the Apo-1/Fas mediated proteolytic cleavage of ADP-ribosyltransferase , a substrate of Interleukin-beta1 converting enzyme ( ICE ) and homologues . Positive_regulation MAPK4 FHL1 23456229 2781820 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Positive_regulation MAPK4 FOXA1 22879989 2641685 An increase in IGFBP-3 , mediated by depletion of , *inhibited* phosphorylation of [MAPK] and Akt , and increased expression of the cell cycle regulators p21 and p27 . Positive_regulation MAPK4 FUT4 20506505 2307958 These data suggested that not only *activates* [MAPK] and PI3K/Akt signals , but also promotes the crosstalk among these signaling pathways . Positive_regulation MAPK4 GLP1R 21356521 2394818 activation by Exendin-4 ( Ex-4 ) *increased* PKA and [MAPK] activity and decreased phosphorylation of AMPK in NTS . Positive_regulation MAPK4 GPR115 10958680 725702 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK4 GPR115 11916960 945454 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK4 GPR115 9182581 435648 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on mediated *activation* of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK4 GPR115 9826186 550045 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK4 GPR132 10958680 725691 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK4 GPR132 11474113 841741 Activation of by LPC *increased* intracellular calcium concentration , induced receptor internalization , activated ERK [mitogen activated protein kinase] , and modified migratory responses of Jurkat T lymphocytes . Positive_regulation MAPK4 GPR132 11916960 945443 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK4 GPR132 9182581 435637 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on mediated *activation* of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK4 GPR132 9826186 550034 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK4 GPR87 10958680 725771 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK4 GPR87 11916960 945523 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK4 GPR87 9182581 435717 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on mediated *activation* of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK4 GPR87 9826186 550114 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK4 HBEGF 10544013 563926 also rapidly *activated* [MAPK] and induced cyclin D1 in mid-G1 with kinetics similar to TGFalpha . Positive_regulation MAPK4 HBEGF 11171084 783797 Both p42 [MAPK] activation and mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation MAPK4 HBEGF 15380451 1298483 *induced* phosphorylation of ERK , p38 [MAPK] and Akt , which were suppressed by ZD1839 . Positive_regulation MAPK4 HBEGF 17928891 1858627 We report that cellular stress with methyl-beta-cyclodextrin ( MBCD ) , a molecule that extracts membrane cholesterol and thereby disrupts the structure of lipid rafts , strongly *induces* the synthesis of ( HB-EGF ) in keratinocytes through the activation of p38 [mitogen activated protein kinase] . Positive_regulation MAPK4 HBEGF 18990151 2028926 *Activation* of [Erk/MAPK] by was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation MAPK4 HBEGF 19048624 2023719 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked MAPK signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 [MAPK] , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Positive_regulation MAPK4 HBEGF 19559571 2110507 *induced* phosphorylation of p42/p44 [MAPK] in a few minutes . Positive_regulation MAPK4 HBEGF 20739666 2345892 Moreover , *induced* a stronger and more sustained activation of both the [mitogen activated protein kinase] and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation MAPK4 HBEGF 24188029 2921108 Here , we show that *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , [Mapk/Erk] pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation MAPK4 HRH1 11959800 931444 1. Previous studies have shown that the *activates* p42/p44 [mitogen activated protein kinases (MAPK)] in DDT ( 1 ) MF-2 smooth muscle cells via a phosphatidylinositol 3-kinase (PI-3K) dependent pathway . Positive_regulation MAPK4 HRH1 17965772 1820342 is *required* for TCR mediated p38 [MAPK] activation and optimal IFN-gamma production in mice . Positive_regulation MAPK4 HRH1 17965772 1820356 Moreover , signaling at the time of TCR ligation was *required* for activation of p38 [MAPK] , a known regulator of IFN-gamma expression . Positive_regulation MAPK4 IFI27 16953232 1682587 RET2A mediated regulation of p18 and , but not of cyclins D1 and D2 , *requires* functional [mitogen activated protein kinase] signaling . Positive_regulation MAPK4 IL1B 10640438 577510 and TNF alpha also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK4 IL1B 10704772 673008 CPI-1189 inhibits *induced* [p38-mitogen activated protein kinase] phosphorylation : an explanation for its neuroprotective properties ? Positive_regulation MAPK4 IL1B 10775561 686647 *activated* p44/42 [MAPK] , and this activation was enhanced in the presence of N-acetyl-L-cysteine . Positive_regulation MAPK4 IL1B 10864897 705732 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK4 IL1B 10864897 705784 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by TNF-alpha and . Positive_regulation MAPK4 IL1B 10864897 705801 TNF-alpha- and *induced* [ ( 3 ) H ] -thymidine incorporation and phosphorylation of p42/p44 [MAPK] was completely inhibited by PD98059 ( an inhibitor of MEK1/2 ) , indicating that activation of MEK1/2 was required for these responses . Positive_regulation MAPK4 IL1B 10969830 728489 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Positive_regulation MAPK4 IL1B 11032891 740457 *induces* p38 [MAPK] phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation MAPK4 IL1B 11037878 741244 also *stimulated* phosphorylation of p38 [MAPK] , SAPK/JNK , and ATF-2 . Positive_regulation MAPK4 IL1B 11126408 759776 TNFalpha and IFNgamma potentiate *induced* [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK4 IL1B 11126408 759789 [Mitogen activated protein kinase (MAPK)] activity that is *induced* by has been suggested to signal nitric oxide dependent as well as nitric oxide independent beta-cell destructive pathways . Positive_regulation MAPK4 IL1B 11126408 759802 The aim of this study was to investigate if TNFalpha and IFNgamma signal through mitogen activated protein kinases in isolated rat islets of Langerhans and if they potentiate [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK4 IL1B 11126408 759815 Further , TNFalpha and IFNgamma were found to synergistically increase [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK4 IL1B 11399523 824263 Glucose potentiates *induced* p38 [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK4 IL1B 11509550 848371 Although and TNF-alpha each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK4 IL1B 11557585 861406 *activated* the three [mitogen activated protein kinase] ( extracellular signal regulated kinases 1 and 2 , c-Jun NH2-terminal kinase/stress activated protein kinase , and p38 ) and the Janus kinase (JAK)-signal transducer and activator of transcription pathways . Positive_regulation MAPK4 IL1B 11698472 878055 *induced* phosphorylation and activation of p38 [MAPK] and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation MAPK4 IL1B 11698472 878101 *induced* phosphorylation of ERK and JNK as well as p38 [MAPK] in human endothelial cells . Positive_regulation MAPK4 IL1B 11728947 884812 We showed a dramatic decrease in *induced* phosphorylation of p38 [MAPK] , not extracellular signal regulated kinases 1/2 or jun NH2-terminal kinase , in rat cultured mesangial cells by FR167653 . Positive_regulation MAPK4 IL1B 11775830 766440 Role of protein tyrosine kinase in *induced* activation of [mitogen activated protein kinase] in fibroblast-like synoviocytes of rheumatoid arthritis . Positive_regulation MAPK4 IL1B 11853544 913374 Interestingly , *induced* p38 [MAPK] activity was greatly enhanced in ( alg+ ) compared with ( alg- ) cells . Positive_regulation MAPK4 IL1B 12117921 964668 mRNA expression by neutrophils was not dependent on p38 MAPK , and p38 [MAPK] was not *activated* in neutrophils incubated with A. phagocytophila . Positive_regulation MAPK4 IL1B 12131776 966865 and TNF-alpha *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK4 IL1B 12139924 969399 Regarding intracellular signaling , *activated* the p38 mitogen activated protein kinase (MAPK) but not the p42/p44 [MAPK] and , when combined with growth factors , intensified p38 activation but inhibited the growth-factor induced p42/p44 activation . Positive_regulation MAPK4 IL1B 12356282 993874 induced p44/42 [mitogen activated protein kinase (MAPK)] *activation* was inhibited by the MAPK/extracellular signal regulated protein kinase ( MEK ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK4 IL1B 12417253 1012956 Sphondin ( 50 microM ) did not affect the *induced* activations of p44/42 [MAPK] , p38 MAPK , and JNK . Positive_regulation MAPK4 IL1B 12500176 1026690 These data suggest that the presence of retinal holes and may *lead* to activation of HGF , [mitogen activated protein kinases (MAPK)] , c-jun and extracellular matrix remodeling , resulting in proliferative and migratory cells in the wounded retina . Positive_regulation MAPK4 IL1B 12507586 1038424 In this study we evaluated the role of epigallocatechin-3-gallate ( EGCG ) , a green tea polyphenol which mimics its anti-inflammatory effects , in modulating the induced *activation* of [MAPK] 's in human chondrocytes . Positive_regulation MAPK4 IL1B 12649265 1080070 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant MKK6 or p38beta2 MAPK inhibited *induced* p38 [MAPK] activation , COX-2 gene expression , and PGE2 release . Positive_regulation MAPK4 IL1B 12727980 1086560 P38 [MAPK] phosphorylation was *increased* by in nondecidualized ESC , whereas the IL-1 beta induced increase was suppressed in the decidualized cells . Positive_regulation MAPK4 IL1B 12727980 1086573 Treatment with 8-bromo-cAMP reduced *induced* phosphorylation of p38 [MAPK] in nondecidualized ESC . Positive_regulation MAPK4 IL1B 12727980 1086587 In contrast , treatment with H89 , a protein kinase A inhibitor , reversed a reduction in *induced* p38 [MAPK] phosphorylation in the decidualized cells . Positive_regulation MAPK4 IL1B 12727980 1086601 The altered property of decidualized cells is thought to be caused by attenuation of *induced* p38 [MAPK] phosphorylation in a way that involves the activation of the cAMP/protein kinase A pathway . Positive_regulation MAPK4 IL1B 12882449 1116292 NAC ( 1 mM ) also decreased the *induced* activation of p38 [MAPK] . Positive_regulation MAPK4 IL1B 12952251 1137420 Using Western-blot analysis , no effect of cAMP was found on the *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK4 IL1B 12952251 1137434 No decrease was observed in *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK4 IL1B 14563491 1154863 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Positive_regulation MAPK4 IL1B 15039421 1251241 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of , and RIP2 dependent *activation* of NF-kappaB and p38 [MAPK] mediated by the caspase recruitment domain . Positive_regulation MAPK4 IL1B 15111866 1241242 We further demonstrated that p38 [MAPK] is *activated* by and PDGF with different kinetics and that p38 MAPK is required for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation MAPK4 IL1B 15208668 1281346 *induced* the activation of extracellular signal regulated kinases-1/2 and P38 [mitogen activated protein kinase (MAPK)] , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation MAPK4 IL1B 15341531 1291764 In accordance with these findings , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) , which was attenuated by U0126 , SB202190 , or SP600125 , respectively . Positive_regulation MAPK4 IL1B 15389584 1354322 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] and JNK which was attenuated by pretreatment with U0126 or SP600125 , respectively . Positive_regulation MAPK4 IL1B 15489374 1359426 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and JNK was attenuated by pretreatment with U0126 , SB-202190 , or SP-600125 , respectively . Positive_regulation MAPK4 IL1B 15755725 1403424 The inhibitory effect of on alpha ENaC expression was *mediated* by the activation of p38 [MAPK] in both rat and human ATII cells and was independent of the activation of alpha v beta6 integrin and transforming growth factor-beta . Positive_regulation MAPK4 IL1B 16033422 1436168 Intrathecal *leads* to a time dependent up-regulation of phosphorylated p38 ( p-p38 ) [MAPK] protein expression in the spinal cord 30-240 min following IL-1beta injection ( i.t. ) . Positive_regulation MAPK4 IL1B 16033422 1436182 However , pretreatment with a p38 MAPK inhibitor significantly reduced the *induced* p-p38 [MAPK] expression by 38-49 % , and nearly completely blocked the subsequent iNOS expression ( reduction by 86.6 % ) , NO production , and thermal hyperalgesia . Positive_regulation MAPK4 IL1B 16043966 1459744 Western blot analysis demonstrated that *increased* the activation of phosphorylated MEK and p38 [MAPK] in GH3 cells . Positive_regulation MAPK4 IL1B 16140882 1450808 *induced* phosphorylation of [p38-MAPK] , but not that of c-Jun-N-terminal kinase or extracellular regulated kinase , was most susceptible to inhibition by low doses of PFE , and the addition of PFE blocked the activity of p38-MAPK in a kinase activity assay . Positive_regulation MAPK4 IL1B 16141635 1454872 DHA stimulated both rapid and prolonged activation of p44/42 , but not p38 , [mitogen activated protein kinase (MAPK)] *induced* by and PMA . Positive_regulation MAPK4 IL1B 16153910 1455443 The kidney was analyzed for expression of tumor necrosis factor alpha , , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 [mitogen activated protein kinase] , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation MAPK4 IL1B 16452991 1611743 Western blots showed that and TNF-alpha *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK4 IL1B 16528573 1549431 The aim of this study was to investigate if Gadd45b prevents *induced* beta cell [MAPK] signalling and apoptosis . Positive_regulation MAPK4 IL1B 16645161 1604680 significantly *increased* the phosphorylation of p38 [MAPK] and cPLA(2) . Positive_regulation MAPK4 IL1B 16698013 1575657 JST ( 0.01-1 mg/ml ) also attenuated the expression of cyclooxygenase (COX)-2 and activation of p38 [MAPK] *induced* by and A beta ( 1-42 ) . Positive_regulation MAPK4 IL1B 16718462 1584912 A synthetic peptide , C3d , reported to bind NCAM , did not activate MAPK or Akt as reported in neurons but inhibited *induced* [MAPK] activity , thereby mimicking the effect of SU5402 . Positive_regulation MAPK4 IL1B 16718462 1584937 We suggest that NCAM signalling through FGFR is required for efficient IL-1beta pro-apoptotic signalling by facilitating induced [MAPK] *activation* downstream of the NF-kappaB-MAPK branching point . Positive_regulation MAPK4 IL1B 16718462 1584978 Further , these data identify a novel function of C3d as an inhibitor of NCAM induced FGFR activity and of *induced* [MAPK] activation in beta cells . Positive_regulation MAPK4 IL1B 16959849 1639701 *caused* an increase in the phosphorylation of ERK , but not [p38MAPK] or c-Jun N-terminal kinase . Positive_regulation MAPK4 IL1B 16964394 1611557 Inhibitors of p38 [MAPK] and/or JNK significantly suppressed VEGF secretion both in the *presence* and absence of , while inhibitors of COX-2 , ERK1/2 , and PI3-K did not . Positive_regulation MAPK4 IL1B 17208222 1695816 Thalidomide also suppressed induced p38 [mitogen activated protein kinase (MAPK)] *activation* , while a p38 MAPK inhibitor destabilized COX-2 mRNA and the cytoplasmic shuttling of HuR induced by IL-1beta . Positive_regulation MAPK4 IL1B 17311279 1719293 *stimulated* phosphorylation of p42/p44 [MAPK] , p38 MAPK , and JNK was attenuated by pretreatment with U0126 , SB202190 , SP600125 , or transfection with these dominant negative mutants of MEK , ERK , p38 and JNK , respectively . Positive_regulation MAPK4 IL1B 17390080 1716140 We have previously demonstrated that *induced* HBD-2 mRNA expression in A549 cells through activation of nuclear factor-kappaB (NF-kappaB) transcriptional factor as well as p38 [mitogen activated protein kinase (MAPK)] , c-Jun N-terminal kinase (JNK) , or phosphatidylinositol-3-kinase (PI3K) . Positive_regulation MAPK4 IL1B 17390080 1716165 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Positive_regulation MAPK4 IL1B 17390080 1716195 Triptolide inhibited *induced* [MAPK] phosphatase-1 expression at the transcriptional level and resulted in sustained phosphorylation of JNK or p38 MAPK , explaining the little effect of triptolide on IL-1beta induced phosphorylation of these kinases . Positive_regulation MAPK4 IL1B 17438131 1742780 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by TNF-alpha and , but not by ansiomycin or sorbitol . Positive_regulation MAPK4 IL1B 17559635 1753265 also *activated* extracellular signal regulated kinase , p38 [MAPK] , and c-Jun N-terminal kinase . Positive_regulation MAPK4 IL1B 17645739 1793273 Interestingly , Dex attenuated *mediated* activation of p38 [MAPK] and JNK , but not of AKT . Positive_regulation MAPK4 IL1B 17694686 1782113 IL-1beta induced NO levels and thermal hyperalgesia in rats , likely via either inhibiting the mediated p38 [MAPK] *activation* and subsequent iNOS induction , or direct attenuation of the central iNOS activity , which therefore reduces the central sensitization of inflammatory pain . Positive_regulation MAPK4 IL1B 17920534 1804193 SA981 at a concentration of 100 microM partially inhibited *induced* phosphorylation of [p38MAPK] and Akt ( 12.0 % and 36.1 % inhibition of each total amount of phosphoprotein under IL-1beta coexistence condition , respectively ) . Positive_regulation MAPK4 IL1B 17925024 1835157 *stimulated* phosphorylation of c-jun amino-terminal kinase , p38 [MAPK] and extracellular signal regulated kinase-1/2 . Positive_regulation MAPK4 IL1B 18026701 1827824 Moreover , glucosamine suppressed the *induced* phosphorylation of p38 [MAPK] ( p < 0.05 at > 0.1 mM ) and the IL-1beta binding to its receptors ( p < 0.05 at 1 mM ) . Positive_regulation MAPK4 IL1B 18065201 1853666 *stimulated* activation of ERK1/2 and p38alpha [MAPK] mediates the transcriptional up-regulation of IL-6 , IL-8 and GRO-alpha in HeLa cells . Positive_regulation MAPK4 IL1B 18348730 1925318 The *activation* or inhibition of p38 [MAPK] by and/or SB203580 was analyzed by western blotting . Positive_regulation MAPK4 IL1B 18348730 1925331 *activated* the phosphorylation of p38 [MAPK] and this effect was abolished by SB203580 . Positive_regulation MAPK4 IL1B 18427719 1920726 Phosphorylated p38 ( Phos-p38 ) [mitogen activated protein kinase] was *stimulated* in SW-1353 cells by but not by HA alone . Positive_regulation MAPK4 IL1B 18556347 1965937 or leptin individually *induced* threonine/tyrosine phosphorylation of p38 [MAPK] , whereas only leptin induced tyrosine phosphorylation of JAK2 , suggesting that leptin may enhance hBD-2 production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with NF-kappaB , which is activated by IL-1beta . Positive_regulation MAPK4 IL1B 18667841 1948055 Furthermore , *induced* p38 [mitogen activated protein kinase (MAPK)] activation and upregulation of VEGF-C mRNA and protein in LLC cells was also suppressed by artemisinin or by the p38 MAPK inhibitor SB-203580 , suggesting that p38 MAPK could serve as a mediator of proinflammatory cytokine induced VEGF-C expression . Positive_regulation MAPK4 IL1B 19362079 2081462 *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 [mitogen activated protein (MAP) kinase] , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation MAPK4 IL1B 19522843 2136342 In chondrocytes , CS diminishes *induced* increases in p38 [mitogen activated protein kinase] ( p38MAPK ) and signal regulated kinase 1/2 ( Erk1/2 ) phosphorylation , and decreases nuclear factor-kappaB (NF-kappaB) nuclear translocation and as a consequence , reduces the formation of pro-inflammatory cytokines , IL-1beta and TNF-alpha , and pro-inflammatory enzymes , such as phospholipase A2 (PLA2) , cyclooxygenase 2 (COX-2) and nitric oxide synthase-2 (NOS-2) . Positive_regulation MAPK4 IL1B 19765281 2163526 Treatment with PIP-18 blocked *induced* p38 [MAPK] phosphorylation and resulted in attenuation of sPLA2-IIA and MMP mRNA transcription in RA SF cells . Positive_regulation MAPK4 IL1B 20060906 2218524 In the present study , we demonstrate that *caused* activation of p38 [mitogen activated protein kinase] and that the p38 inhibitor SB203580 significantly blocked the effect of IL-1beta on I ( NMDA-OUT ) in hippocampal CA1 neurons . Positive_regulation MAPK4 IL1B 20353947 2266477 In model 1 , a differentiation model , CLA *activation* of [MAPK] and induction of interleukin-8 (IL-8) , IL-6 , , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation MAPK4 IL1B 21659536 2455197 Distinct roles for Nod2 protein and autocrine in muramyl dipeptide *induced* [mitogen activated protein kinase] activation and cytokine secretion in human macrophages . Positive_regulation MAPK4 IL1B 24692548 2935248 At 1 h , this was responsible for the dexamethasone inhibition of induced [MAPK] *activation* and CXCL1 and CXCL2 mRNA expression , with a similar trend for CSF2 . Positive_regulation MAPK4 IL1B 9475519 486794 Of these , *activated* only [MAPK] . Positive_regulation MAPK4 IL1B 9475519 486807 In cultured rat astrocytes , *caused* activation of [MAPK] without inducing proliferation . Positive_regulation MAPK4 IL1B 9575890 502744 Our data also indicate that both insulin and IGF-I enhance *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation and SAPK activation . Positive_regulation MAPK4 IL1B 9582321 503939 Previously we reported that *induces* activation of JNK/SAPK and p38 [MAPK] with concomitant up-regulation of cyclooxygenase (Cox)-2 expression and prostaglandin E2 ( PGE2 ) synthesis . Positive_regulation MAPK4 IL1B 9614146 509332 By Western blotting with phosphospecific antibodies and by immunocomplex kinase assay , was shown to *activate* extracellular signal regulated kinase ( ERK ) 1/2 and p38 [mitogen activated protein kinase] ( p38 ) in islets and rat insulinoma cells . Positive_regulation MAPK4 IL1B 9786861 540917 We reported previously that rapidly *activates* the c-Jun NH2-terminal/stress activated protein kinases ( JNK/SAPK ) and p38 [mitogen activated protein kinase (MAPK)] and also induces Cox-2 expression and prostaglandin E2 ( PGE2 ) production . Positive_regulation MAPK4 IL1B 9786861 540963 Overexpression of the kinase-dead form of MKK3 or MKK6 demonstrated that either of these two mutant kinases inhibited *induced* p38 [MAPK] phosphorylation and Cox-2 expression but not JNK/SAPK phosphorylation and activation . Positive_regulation MAPK4 ITGB2 12600815 1099076 IL-3 , IL-5 , and GM-CSF could enhance p38 [MAPK] and NF-kappaB activity and *induce* ICAM-1 , CD11b , and expressions on eosinophils . Positive_regulation MAPK4 ITGB2 19843511 2203204 Furthermore , beta2 integrins modulated the capacity of isolated peritoneal macrophages to take up acetylated LDL and native LDL and to phagocytose apoptotic cells , possibly via *dependent* [mitogen activated protein kinase] signalling . Positive_regulation MAPK4 LBP 20615568 2309956 Despite activating NFkappaB , NOD1 ligand did not upregulate hepatocyte production of the acute phase proteins lipopolysaccharide binding protein , serum amyloid A , or soluble CD14 in cell culture supernatants , or upregulate mRNA expression of , serum amyloid A , C-reactive protein , or serum amyloid P . NOD2 ligand ( MDP ) did not *activate* hepatocytes when given alone , but did synergize with Toll-like receptor ligands , lipopolysaccharide (LPS) , and polyI : C to activate NFkappaB and [MAPK] . Positive_regulation MAPK4 MAP2K6 10050043 592961 In one set of experiments , we *inhibited* the activation of [MAPK] by pretreating cells with PD098059 , a specific inhibitor of ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAPK4 MAP2K6 10079106 595491 Although MKK3 , MKK4 , and all *activated* p38 [MAPk] in experimental models , only MKK3 was found to activate recombinant p38 MAPk in LPS treated neutrophils . Positive_regulation MAPK4 MAP2K6 10471331 641644 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Positive_regulation MAPK4 MAP2K6 10601295 574421 In addition , *activation* of p38 [MAPK] by constitutively active or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAPK4 MAP2K6 10713051 674412 Conversely , the inhibitors PD98059 and UO126 could *attenuate* EGF induced [mitogen activated protein kinase] activation , they do not affect the EGF induced mobility shift of caveolin-1 . Positive_regulation MAPK4 MAP2K6 10759527 683180 These results demonstrate that a plant can phosphorylate and *activate* [MAPK] , and that Tyr phosphorylation is critical for the catalytic activity of MAPK in plants . Positive_regulation MAPK4 MAP2K6 10816593 714750 The MAPK kinase selectively *stimulates* p38 [MAPK] and confers protection against stress induced apoptosis in cardiac myocytes . Positive_regulation MAPK4 MAP2K6 10891559 711224 MAP kinases (MAPK) in both G-1 and G-5 cells were indistinguishably phosphorylated , yet dependent [MAPK] *activation* was observed only in G-5 cells . Positive_regulation MAPK4 MAP2K6 11005808 752451 A inhibitor , PD98059 , *inhibited* heat shock ERK [MAPK] activation by > 75 % . Positive_regulation MAPK4 MAP2K6 11085935 750739 Similarly , *activation* of JNK by Ad-MKK7D and [p38-MAPK] by resulted in the increased expression of PGHS-2 . Positive_regulation MAPK4 MAP2K6 11237743 790336 The MAPK kinase ( ) inhibitor , PD98059 , *blocked* GSA stimulated [MAPK] activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Positive_regulation MAPK4 MAP2K6 11304531 826842 The *activation* of p38 [MAPK] by Galpha ( q ) and Gbetagamma was blocked by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Positive_regulation MAPK4 MAP2K6 11787422 891958 Indeed the MAPK kinase ( = ) inhibitor PD98059 *inhibits* the activation of parasite [MAPK] , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Positive_regulation MAPK4 MAP2K6 11822870 909086 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of [MAPK] pathway *inhibitors* ( inhibitors PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAPK4 MAP2K6 12009309 940844 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Positive_regulation MAPK4 MAP2K6 12203369 983250 Furthermore , PKC inhibitors or an inhibitor completely *suppressed* both TPA induced activation of [MAPK] and promotion of anchorage independent growth , but a cPKC-selective inhibitor partially suppressed TPA induced promotion of the growth . Positive_regulation MAPK4 MAP2K6 12356282 993880 IL-1beta induced p44/42 [mitogen activated protein kinase (MAPK)] activation was *inhibited* by the MAPK/extracellular signal regulated protein kinase ( ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK4 MAP2K6 12377770 1019994 These results suggest that MKK3 , rather than , *mediates* alphav integrin induced p38 [MAPK] activation . Positive_regulation MAPK4 MAP2K6 12450322 1018668 ANG II significantly increased aldosterone release , and this effect was inhibited by the LO inhibitor baicalein , as well as a specific p38 [MAPK] *inhibitor* , SB202190 , but not by PD098059 , a specific inhibitor of the ERK activator . Positive_regulation MAPK4 MAP2K6 12637559 1085516 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Positive_regulation MAPK4 MAP2K6 12659851 1073540 MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a ( MAP2K ) , which in turn *activates* a [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK4 MAP2K6 12845643 1108620 Finally , both ODQ and UO126 blocked the capacity of L-arginine to restore ERK ( 1/2 ) phosphorylation in L-NAME treated cells , demonstrating that GC and are both *required* for endogenous NO-mediated [MAPK] activation . Positive_regulation MAPK4 MAP2K6 15104236 1240339 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( ) inhibitor , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAPK4 MAP2K6 15172888 1288416 Importantly , the presence of inhibitors only at the time of the transport assay markedly *impaired* both insulin stimulated glucose uptake and [MAPK] signaling . Positive_regulation MAPK4 MAP2K6 15172888 1288511 Conversely , removal of inhibitors before the transport assay *restored* glucose uptake and [MAPK] signaling . Positive_regulation MAPK4 MAP2K6 15304546 1322538 Furthermore , *activation* of [ERK/MAPK] by the coexpression of constitutively active predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAPK4 MAP2K6 15365248 1294596 Treatment of keratinocytes with PD98059 , inhibitor , and SB20358 , p38 [MAPK] *inhibitor* , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAPK4 MAP2K6 15570612 1355592 Although the inhibitors *suppressed* [MAPK] phosphorylation in both OA- and AICAR treated oocytes , meiotic resumption was not causally linked to MAPK phosphorylation in either group . Positive_regulation MAPK4 MAP2K6 15867183 1404246 In cultured cardiac myocytes , specific *activation* of stress activated [mitogen activated protein kinase] , p38 , by upstream activator led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAPK4 MAP2K6 15879307 1411361 Conversely , constitutively active *induced* p38 [MAPK] activation that recapitulated the effects of polyphenols by inducing ERalpha phosphorylation and downstream activation of Akt , and eNOS . Positive_regulation MAPK4 MAP2K6 16157033 1455788 SB203580 , a [P38MAPK] *inhibitor* , and U0126 , a inhibitor , both completely blocked ADM mediated responses in MsC . Positive_regulation MAPK4 MAP2K6 17416211 1777909 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK4 MAP2K6 18401006 1925861 CyaA enhanced LPS induced phosphorylation of p38 [MAPK] and ERK in DC , and inhibitors of p38 MAPK , , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation MAPK4 MAP2K6 18754769 1968464 ( MKK) 3 and 6 are the main p38 [mitogen activated protein kinase] *activators* in mammals . Positive_regulation MAPK4 MAP2K6 18771907 1962709 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a inhibitor , and SB203580 , an *inhibitor* of p38 [mitogen activated protein (MAP) kinase] , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAPK4 MAP2K6 21892182 2491666 Further , we show that *activation* of p38 [MAPK] by expression of constitutively active ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAPK4 MAP2K6 22164285 2517914 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of and marked *activation* of p38 [MAPK] . Positive_regulation MAPK4 MAP2K6 22785235 2691922 TRH induced CRE promoter was inhibited by [mitogen activated protein kinase/ERK] kinase ( MEK ) inhibitor and was *increased* by overexpression of . Positive_regulation MAPK4 MAP2K6 7644477 318693 Inhibition of by PD 098059 *prevented* activation of [MAPK] and subsequent phosphorylation of MAPK substrates both in vitro and in intact cells . Positive_regulation MAPK4 MAP2K6 7822248 285626 ( MKK ) phosphorylates and *activates* [mitogen activated protein kinase (MAPK)] in response to stimulation of various eukaryotic signaling pathways . Positive_regulation MAPK4 MAP2K6 7889302 289470 2. Both nucleotides stimulate phosphorylation and *activation* of [mitogen activated protein kinase] and a biphasic phosphorylation of the up-stream . Positive_regulation MAPK4 MAP2K6 8180183 256270 This stimulation of the activator was temporally *followed* by increased activities of MEK and [MAPK] . Positive_regulation MAPK4 MAP2K6 8226933 235441 *Activation* of extracellular signal regulated kinase ( ERK ) or [mitogen activated protein kinase] by ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAPK4 MAP2K6 8394352 228271 We show that a similar activity phosphorylates and *activates* [MAPK] in both growth factor stimulated ( epidermal growth factor and thrombin ) and oncogene ( gip2 , v-src , and v-raf ) -transfected cells . Positive_regulation MAPK4 MAP2K6 8550616 346702 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Positive_regulation MAPK4 MAP2K6 8663100 368188 The [MAPK] and NHE activities induced by PMA were *inhibited* by staurosporine , a potent inhibitor for protein kinase C ( PKC ) , and by MAPK kinase ( ) inhibitor , PD98059 , but were not affected by the tyrosine kinase inhibitor genistein . Positive_regulation MAPK4 MAP2K6 8663100 368287 In contrast , both AVP induced [MAPK] and NHE activities were *inhibited* by genistein and inhibitor but were not affected by staurosporine . Positive_regulation MAPK4 MAP2K6 8816498 384325 *activates* [mitogen activated protein kinase (MAPK)] , which phosphorylates other kinases as well as transcription factors . Positive_regulation MAPK4 MAP2K6 9135064 427642 In addition to dependent [MAPK] *activation* , we provide evidence for MEK independent regulation of the MAPKs . Positive_regulation MAPK4 MAP2K6 9166761 432490 The first step in [MAPK] *activation* by must be the formation of a MEK x MAPK enzyme-substrate complex , followed by phosphorylation producing monophosphorylated MAPK ( pMAPK ) . Positive_regulation MAPK4 MAP2K6 9626658 511928 These results indicate that *mediates* the IGF-I/insulin induced p42/ p44 [MAPK] activation . Positive_regulation MAPK4 MAP2K6 9864179 582759 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of ERK , but not p38 [MAPK] , induced by G-CSF , GM-CSF , or TNF . Positive_regulation MAPK4 MMP7 16848631 1588327 and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 [mitogen activated protein kinase] activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MAPK4 MMP7 21999204 2547388 Mesothelin enhances invasion of ovarian cancer by *inducing* through [MAPK/ERK] and JNK pathways . Positive_regulation MAPK4 MUC16 11481474 843909 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a [mitogen activated protein kinase] ( Erk 1/2 ) , and *activation* of transcription . Positive_regulation MAPK4 PECAM1 18029285 1866925 In contrast , expression of Delta15 in PECAM-1-/- bEND cells *had* minimal effects on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Positive_regulation MAPK4 PGC 22105890 2599545 Our studies also revealed that overexpression of in cardiomyocytes *inhibited* basal and T3-induced p38 [MAPK] phosphorylation . Positive_regulation MAPK4 PIGR 20450283 2257151 Induction of expression in HT-29 cells *required* NF-kappaB signaling but not [MAPK] signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation MAPK4 PLAT 19436314 2107042 cerebrospinal fluid and brain parenchymal ERK [MAPK] was elevated by H/I and this upregulation was *potentiated* by , but blunted by RBC-tPA . Positive_regulation MAPK4 PLAT 21037505 2499498 Red blood blocked c-Jun-N-terminal kinase but *potentiated* p38 [mitogen activated protein kinase] upregulation after photothrombotic injury . Positive_regulation MAPK4 PLAU 10766865 684608 surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha [mitogen activated protein kinase] activity . Positive_regulation MAPK4 PLAU 15031204 1257172 In HeLa cells the dominant negative form of JNK interferes with the p42/p44 [MAPK] *activation* of the . Positive_regulation MAPK4 PLAU 15874933 1405701 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 [MAPK] , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Positive_regulation MAPK4 PLAU 15874933 1405734 Although *induced* phosphorylation of both ERK1/2 and p38 [MAPK] was blocked by Galphai inhibition , inhibition of PI3K and Ras decreased the uPA induced phosphorylation of ERK1/2 but not p38 MAPK . Positive_regulation MAPK4 PLAU 18656457 1960567 Exogenous administered at 4 h post H/I further *stimulated* ERK [MAPK] phosphorylation , which was blocked by RAP . Positive_regulation MAPK4 PLAU 9660790 517502 The receptor *mediates* tyrosine phosphorylation of focal adhesion proteins and activation of [mitogen activated protein kinase] in cultured endothelial cells . Positive_regulation MAPK4 PLAU 9660790 517515 The *induced* activation of [MAPK] was completely inhibited by genistein , but not by 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo [ 3 , 4-d ] pyrimidine , a specific inhibitor of Src family kinases . Positive_regulation MAPK4 PODXL 17616675 1769276 expression also *led* to an increase in [mitogen activated protein kinase (MAPK)] and phosphatidylinositol 3-kinase (PI3K) activity . Positive_regulation MAPK4 PODXL 17616675 1769323 These findings suggest that leads to increased in vitro migration and invasion , increased MMP expression , and *increased* activation of [MAPK] and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MAPK4 PTGER2 19233324 2072062 Further , PGE ( 2 ) , EP2A and EP4A did not increase BMP2/4 mRNA levels in RC cells , and *induced* phosphorylation of p38 [MAPK] was not eliminated by Noggin . Positive_regulation MAPK4 SLC38A3 15331357 1288032 In contrast , *stimulated* [MAPK] activation was blocked by > 80 % by dominant negative Ras but not by dominant negative Rho and Cdc42 . Positive_regulation MAPK4 SNCAIP 12639553 1068706 In addition , [MAPK] was *activated* by through Edg-1 , Sph-1-P receptor . Positive_regulation MAPK4 SPHK1 18602364 1941510 As a result , inhibition of by SKI *blocked* phosphorylation of p38 [MAPK] , showing that SPHK activation by IL-18 is an upstream signal of p38 MAPK activation . Positive_regulation MAPK4 STK39 17237610 1690316 The phosphorylation of cytoplasmic p38 [MAPK] in Akata cells was *reduced* by the inhibitor , 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperazine ( H7 ) . Positive_regulation MAPK4 TLR7 16424221 1515595 MKP-1-deficient macrophages also show enhanced constitutive and *induced* activation of p38 [MAPK] . Positive_regulation MAPK4 TLR7 23979601 2850675 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Positive_regulation MAPK4 TLR7 24879442 2941026 GIT2 terminates *induced* NF-?B and [MAPK] signaling by recruiting the deubiquitinating enzyme Cylindromatosis to inhibit the ubiquitination of TRAF6 . Positive_regulation MAPK4 TNF 10504489 648985 Pretreatment with SB203580 ( 10 microM ) had no effect on basal or TNF-alpha stimulated phosphorylation of p38 MAPK but completely abolished *stimulated* p38 [MAPK] activity . Positive_regulation MAPK4 TNF 10521481 653115 The study presented here shows that autoregulation of gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 [mitogen activated protein (MAP) kinase] activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation MAPK4 TNF 10570180 568163 Furthermore , LPS , UV irradiation , and *caused* activation of p38 [MAPK] whereas IFN-gamma did not . Positive_regulation MAPK4 TNF 10601128 574212 alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation MAPK4 TNF 10640438 577509 IL-1 beta and also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK4 TNF 10669634 665810 In this study , we show that *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation MAPK4 TNF 10753884 682345 Moreover , *stimulated* both the NF-kappaB and [mitogen activated protein (MAP) kinase] ( extracellular signal regulated kinase , c-Jun NH ( 2 ) -terminal kinase , and p38 MAP kinase ) signaling pathways in astrocytes . Positive_regulation MAPK4 TNF 10783388 707852 dependent p38 [MAPK] *activation* was detected in both Mo7e and Hut-78 cells and was blocked by the p38 MAPK inhibitor , SB203580 . Positive_regulation MAPK4 TNF 10783388 707905 SB203580 did not affect TNF-alpha signaled nuclear translocation and DNA binding activity of NF-kappaB , and inhibition of NF-kappaB function did not affect *induced* p38 [MAPK] activation , indicating that these events are not dependent on each other . Positive_regulation MAPK4 TNF 10864897 705731 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK4 TNF 10864897 705783 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by and IL-1beta . Positive_regulation MAPK4 TNF 11095634 755302 rapidly *activated* [MAPK] and increased the extent of attachment , spreading and migration on fibronectin and collagen type I ( P < 0.01 ) but not on collagen type IV . Positive_regulation MAPK4 TNF 11108246 756731 *activates* extracellular regulated kinase-1/2 ( ERK1/2 ) and [p38MAPK] . Positive_regulation MAPK4 TNF 11108836 757042 In RAW264 cells which differentiate into osteoclast-like multinucleated cells by TNF treatment alone , activation of p38 [mitogen activated protein (MAP) kinase] *induced* by murine was comparable to and independent of the receptor activator of necrosis factor-kappaB ligand . Positive_regulation MAPK4 TNF 11156586 780618 1. We have previously shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce interleukin-8 (IL-8) by human pulmonary vascular endothelial cells . Positive_regulation MAPK4 TNF 11167962 783069 It has previously been shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce cytokine , including RANTES , that N-acetylcysteine (NAC) attenuates cytokine production by human bronchial epithelial cells ( BECs ) , and that sensitivity to TNFalpha is inversely correlated with cellular redox state . Positive_regulation MAPK4 TNF 11266661 797172 However , *caused* no activation of p42/p44 [MAPK] or cytosolic phospholipase A(2) activity . Positive_regulation MAPK4 TNF 11277995 798114 *activates* extracellular regulated kinases ( ERKs ) and p38 [mitogen activated protein kinase] ( p38MAPK ) , and inhibits the expression of uncoupling protein-1 (UCP-1) and adipocyte-specific genes in rat fetal brown adipocytes . Positive_regulation MAPK4 TNF 11319753 806842 SB 203580 , a selective inhibitor of p38 MAPK , inhibited IL-1 and *induced* p38 [MAPK] activity and IL-6 production ( IC ( 50 ) s 0.3 -- 0.5 microM ) in osteoblasts and chondrocytes . Positive_regulation MAPK4 TNF 11319753 806871 In addition , IL-1 and also *activated* p38 [MAPK] in fetal rat long bones and p38 MAPK inhibitors inhibited IL-1- and TNF stimulated bone resorption in vitro in a dose dependent manner ( IC ( 50 ) s 0.3 -- 1 microM ) . Positive_regulation MAPK4 TNF 11435466 832532 However , the cytotoxic responses to daunorubicin and exogenous ceramide remain unaltered , as do the induced p42/p44 [MAPK] *activation* and CD54 expression . Positive_regulation MAPK4 TNF 11438547 843397 *activated* p38 [MAPK] and p44/p42 MAPK in wild-type but not in p60 ( -/- ) , p80 ( -/- ) , or p60 ( -/- ) p80 ( -/- ) macrophages . Positive_regulation MAPK4 TNF 11494147 846176 In this study we demonstrate that *triggers* only modest proliferation , as well as p44/p42 [mitogen activated protein kinase (MAPK)] and NF-kappaB activation , in MM.1S multiple myeloma ( MM ) cells . Positive_regulation MAPK4 TNF 11495721 846398 Furthermore , overexpression of dominant negative mutants , H-Ras-15A and Raf-N4 , significantly suppressed p42/p44 [mitogen activated protein kinase (MAPK)] activation *induced* by and PDGF-BB and attenuated the effect of TNF-alpha on BK-induced IP response , indicating that Ras and Raf may be required for activation of these kinases . Positive_regulation MAPK4 TNF 11509550 848369 Although IL-1 beta and each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK4 TNF 11592111 869667 Lipopolysaccharide (LPS) treatment of a microglial cell line ( N9 ) *induced* a time dependent activation of both p38 [mitogen activated protein kinase] ( p38 MAPK ) and nuclear factor-kappaB (NFkappaB) , with consequent increases in interleukin-1alpha (IL-1alpha) , , and nitric oxide ( NO ) production . Positive_regulation MAPK4 TNF 11694522 896417 *activated* the three mammalian [MAPK] , p44/42 , JNK , and p38 , in a distinct time- and concentration dependent manner . Positive_regulation MAPK4 TNF 11694522 896443 In conclusion , although *activates* all three known [MAPK] in human preadipocytes , only p44/42 and JNK appear to be involved in the regulation of lipolysis . Positive_regulation MAPK4 TNF 11750919 898175 Biochemical and immunocytochemical analysis showed that *activated* p38 [mitogen activated protein kinase] ( p38MAPK ) and c-Jun N-terminal kinase (JNK) but not p42/p44 MAPK . Positive_regulation MAPK4 TNF 11820362 908742 *activated* p38 [MAPK] and stimulated IL-6 secretion by MG-63 cells , and pre-incubation of cells with the p38 MAPK inhibitor abrogated TNF-alpha dependent IL-6 secretion . Positive_regulation MAPK4 TNF 11820362 908771 Transfection of IL-6 full-length and 5-deletion gene promoter reporter constructs indicated that p38 [MAPK] *activation* by enhanced IL-6 gene expression , and that the p38 MAPK-responsive region resided in the proximal 260-bp segment . Positive_regulation MAPK4 TNF 11820362 908807 In conclusion , although p38 [MAPK] *activation* by stimulates IL-6 secretion by MG-63 cells , it has opposing effects on c/EBPbeta and NFkappaB activity . Positive_regulation MAPK4 TNF 11930247 927422 The p44/42 [MAPK] activity was significantly *enhanced* by and the TNF-alpha effect was opposed by rhIL-10 . Positive_regulation MAPK4 TNF 11930247 927435 It is suggested that rhIL-10 can inhibit *induced* VSMC proliferation and phosphorylation of p44/42 [MAPK] . Positive_regulation MAPK4 TNF 12095140 960568 significantly increased permeability and *induced* p38 and ERK [MAPK] activation compared with controls ( P < 0.05 ) . Positive_regulation MAPK4 TNF 12114204 963998 *increased* the phosphorylation of p38 [MAPK] within 15 min. Anisomycin , an activator of p38 MAPK , increased p38 MAPK phosphorylation and decreased SP-A mRNA levels in a dose dependent manner . Positive_regulation MAPK4 TNF 12130576 966586 Phosphorylation of p38 [MAPK] was *induced* by RANKL , IL-1 , , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation MAPK4 TNF 12131776 966864 IL-1 beta and *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK4 TNF 12297009 991041 In this study , we examined the anti-apoptotic role of p38 [MAPK] that is *activated* by in neuronal PC12 cells . Positive_regulation MAPK4 TNF 12297009 991054 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Positive_regulation MAPK4 TNF 12393915 1025441 This model probiotic also inhibits *activation* of the pro-apoptotic [p38/mitogen activated protein kinase] by , interleukin-1alpha , or gamma-interferon . Positive_regulation MAPK4 TNF 12511413 1079046 The treatment of RAW264 cells with TSA and NaB inhibited *induced* nuclear translocation of NF-kappa B and sRANKL induced activation of p38 [mitogen activated protein kinase (MAPK)] signals . Positive_regulation MAPK4 TNF 12631113 1067619 Additional experiments examining the role of cAMP on MC fractalkine expression showed that the incubation of MCs with TNF-alpha and either db-cAMP or forskolin attenuated TNF-alpha stimulated fractalkine mRNA and protein expression , preceded by attenuation of *activated* phosphorylation of p42/44 [MAPK] , and c-Jun , but not phosphorylation of PKCzeta/iota or nuclear translocation of NF-kappaB . Positive_regulation MAPK4 TNF 12637577 1099317 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and *requires* p38 [MAPK] activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation MAPK4 TNF 12665666 1030374 This study was undertaken to examine the relationship between induced cardiomyocyte apoptosis and *activation* of p38 [mitogen activated protein kinase (MAPK)] through oxidative stress . Positive_regulation MAPK4 TNF 12665666 1030387 Corresponding to the apoptotic effect , at 10 ng/mL *caused* rapid phosphorylation of p38 [MAPK] in wild-type cardiomyocytes . Positive_regulation MAPK4 TNF 12694807 1080913 *induced* the phosphorylation of p44/p42 [mitogen activated protein (MAP) kinase] and p38 MAP kinase . Positive_regulation MAPK4 TNF 12731668 1086849 On the other hand , GM-CSF- or *induced* phosphorylation of ERK and p38 [MAPK] was unaffected by these inhibitors at the concentrations effective for the inhibition of O2- release and adherence . Positive_regulation MAPK4 TNF 12829618 1113808 However , *induced* [p38-MAPK] phosphorylation was markedly diminished in mkk3-/- vs mkk3+/+ hearts ( percent basal , 127+/-23 versus 540+/-267 , respectively , P=0.04 ) , suggesting an MKK independent activation mechanism by ischemia . Positive_regulation MAPK4 TNF 12844496 1149732 Rho inhibition decreases induced endothelial [MAPK] *activation* and monolayer permeability . Positive_regulation MAPK4 TNF 12844496 1149745 Because GTP binding proteins have been implicated in MAPK activation , we now hypothesize that the GTP binding protein Rho is a mediator of *induced* [MAPK] activation and increased endothelial permeability . Positive_regulation MAPK4 TNF 12844496 1149759 C3 transferase attenuated *induced* [MAPK] activation and blocked TNF induced endothelial permeability . Positive_regulation MAPK4 TNF 12867430 1142010 Subsequently , mediated p38 [MAPK] *activation* induced sialidase activity and CD44-HA binding . Positive_regulation MAPK4 TNF 12867430 1142109 Taken together , our results suggest that *induced* p38 [MAPK] activation may regulate the induction of functionally active HA-binding form of CD44 by activating sialidase in LPS stimulated human monocytic cells . Positive_regulation MAPK4 TNF 12881424 1116134 Importantly , does not induce ROS accumulation or prolonged MAPK activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently *induces* prolonged [MAPK] activation and necrotic cell death Positive_regulation MAPK4 TNF 12893778 1121032 We show that MKK3 and MKK6are essential for *stimulated* p38 [MAPK] activation . Positive_regulation MAPK4 TNF 12960255 1158290 To investigate a potential interplay between induced *activation* of p38 [MAPK] and NF-kappaB , the p38 MAPK inhibitor SB203580 and a dominant negative p38 MAPK mutant were used . Positive_regulation MAPK4 TNF 14516792 1147206 [MAPK] pathway *activation* via was confirmed by marked AP-1 activation detected in EMSA . Positive_regulation MAPK4 TNF 14561851 1165108 In cultured human umbilical vein endothelial cells ( HUVECs ) , and lipopolysaccharide *increased* phosphorylation of p38 [MAPK] ( P-p38 MAPK ) and increased ICAM-1 expression . Positive_regulation MAPK4 TNF 14592823 1209467 Analyzing the individual contribution of PF-4 and its costimuli in the control of these functions at the signaling level , we demonstrate that *induced* activation of p38 [mitogen activated protein (MAP) kinase] ( but not extracellular regulated kinase [ Erk ] kinases ) acts as general and essential costimulatory signal in PF-4 dependent neutrophil exocytosis . Positive_regulation MAPK4 TNF 14632659 1170653 *activated* p38 [MAPK] in DCs only at an early time-point ( 15 min ) . Positive_regulation MAPK4 TNF 14654378 1176831 These findings suggest that the pre-ischemic *activation* of [p38-MAPK] by does not contribute to cardioprotection afforded by this agent . Positive_regulation MAPK4 TNF 15002040 1265086 Consistent with the abrogation of osteoclastogenic effect of DcR3 by TNFR-Fc , DcR3 treatment can *induce* osteoclastogenic cytokine release through ERK and p38 [MAPK] signaling pathways . Positive_regulation MAPK4 TNF 15139014 1246960 The increase in release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not [mitogen activated protein kinase (MAPK)] , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation MAPK4 TNF 15191888 1295242 Treatment of endothelial cells with SphK1 siRNA suppressed *induced* increase in MCP-1 mRNA levels , MCP-1 protein secretion , and activation of p38 [MAPK] . Positive_regulation MAPK4 TNF 15212763 1262322 Interestingly , Ad5NIK , but not , *induces* RelA S536 and p38 [mitogen activated protein kinase (MAPK)] phosphorylation in IKKgamma ( -/- ) cells . Positive_regulation MAPK4 TNF 15233873 1269393 A. semen also inhibited the expression of and the *activation* of [mitogen activated protein kinase] , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation MAPK4 TNF 15240695 1270285 TNF activates Syk protein tyrosine kinase leading to induced [MAPK] *activation* , NF-kappaB activation , and apoptosis . Positive_regulation MAPK4 TNF 15240695 1270305 TNF induced Syk activation was abolished by piceatannol ( Syk-selective inhibitor ) , which led to the suppression of *induced* activation of c- JNK , p38 [MAPK] , and p44/p42 MAPK . Positive_regulation MAPK4 TNF 15240695 1270321 Jurkat cells that did not express Syk ( JCaM1 , JCaM1/lck ) showed lack of *induced* Syk , JNK , p38 MAPK , and p44/p42 [MAPK] activation , as well as TNF induced IkappaBalpha phosphorylation , IkappaBalpha degradation , and NF-kappaB activation . Positive_regulation MAPK4 TNF 15240695 1270352 Overall , our results demonstrate that Syk activation plays an essential role in *induced* activation of JNK , p38 [MAPK] , p44/p42 MAPK , NF-kappaB , and apoptosis . Positive_regulation MAPK4 TNF 15240725 1270460 p38 [MAPK] was *activated* by and oxidants in nonadherent conditions i.e. , with 10 mM EDTA . Positive_regulation MAPK4 TNF 15240725 1270474 Finally , p38 [MAPK] *activation* by was blocked by diphenylene iodonium , an inhibitor of flavoprotein oxidoreductase , and by the free radical scavenger N-acetylcystein . Positive_regulation MAPK4 TNF 15265936 1275736 Besides NF-kappa B , celecoxib also suppressed *induced* JNK , p38 [MAPK] , and ERK activation . Positive_regulation MAPK4 TNF 15290420 1278553 Halothane or isoflurane augmented the LPS- and *induced* activation of p38 [MAPK] . Positive_regulation MAPK4 TNF 15304089 1284482 DNCB , NiSO ( 4 ) and *activated* p38 [mitogen activated protein kinases (MAPK)] and c-jun N-terminal kinase ( JNK ) . Positive_regulation MAPK4 TNF 15322069 1333424 We have also investigated the phosphorylation of p42/44 [MAPK] and *upregulation* of RhoA protein by . Positive_regulation MAPK4 TNF 15452110 1341995 In contrast , induced p42/p44 [MAPK] *activation* and CD54 expression remained unaltered . Positive_regulation MAPK4 TNF 15589482 1356215 In addition , luteolin inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , IkappaB degradation , and NF-kappaB activation . Positive_regulation MAPK4 TNF 15659876 1350312 The anabolic effect of was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an extracellular regulated kinases (ERK) . Positive_regulation MAPK4 TNF 15696169 1372166 Using TCPTP-deficient fibroblasts , we show here that TCPTP regulates *induced* [MAPK] but not NF-kappaB signaling . Positive_regulation MAPK4 TNF 15696169 1372204 These results link TCPTP and Src tyrosine kinases to the selective regulation of *induced* [MAPK] signaling and identify a previously unknown mechanism for modulating inflammatory responses mediated by TNF . Positive_regulation MAPK4 TNF 15703956 1497471 *Activation* of p38 [mitogen activated protein (MAP) kinase] and phosphatidylinositol 3-kinase (PI3K) by was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation MAPK4 TNF 15792609 1386797 By stimulation of in AM-1 cells , the phosphorylation of Akt ( Ser473 ) and p44/42 [mitogen activated protein kinase (MAPK)] ( Thr202/Tyr204 ) was markedly *increased* in TNFalpha concentration and time dependent manner . Positive_regulation MAPK4 TNF 15792609 1386810 Pretreatment with U0126 , mitogen activated extracellular regulated kinase ( MEK) 1/2 inhibitor , prior to TNFalpha stimulation , specifically inhibited *induced* phosphorylation of p44/42 [MAPK] ( Thr202/Tyr204 ) in AM-1 cells . Positive_regulation MAPK4 TNF 15792609 1386826 Meanwhile , pretreatment with LY294002 , phosphatidylinositol-3-OH kinase (PI3K) inhibitor , could inhibit both *induced* phosphorylation of Akt ( Ser473 ) and p44/42 [MAPK] ( Thr202/Tyr204 ) . Positive_regulation MAPK4 TNF 15823554 1393915 Furthermore , potently *activated* p38 [MAPK] , JNK , and NF-kappaB . Positive_regulation MAPK4 TNF 15837794 1432552 Expression of this protein inhibited *induced* activation of NFkappaB , JNK , and p38 [MAPK] and sensitized the cells to TNF induced apoptosis . Positive_regulation MAPK4 TNF 15845648 1425550 *induces* a more than tenfold increase in p38 [mitogen activated protein kinase (MAPK)] but not extracellular signal regulated kinase phosphorylation . Positive_regulation MAPK4 TNF 15870903 1405550 In addition , GA inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , I kappa B alpha degradation , and NF-kappa B activation . Positive_regulation MAPK4 TNF 16009485 1441409 Moreover , p44/42 [mitogen activated protein kinase] appears to partly *mediate* the negative effect of insulin but not on ATGL . Positive_regulation MAPK4 TNF 16023081 1441591 Ellagic acid inhibited IL-1beta- and induced *activation* of activator protein-1 and mitogen activated protein kinases ( extracellular signal regulated kinase , c-Jun N-terminal kinase and p38 [mitogen activated protein kinase] ) , but not of nuclear factor-kappaB . Positive_regulation MAPK4 TNF 16025396 1435614 *activated* the phosphorylation of p44/42 MAPK , p38 [MAPK] , SAPK/JNK and Akt in mesangial cells . Positive_regulation MAPK4 TNF 16025396 1435630 PGE1 inhibited the *induced* phosphorylation of SAPK/JNK and Akt , but not p44/42 [MAPK] and p38 MAPK . Positive_regulation MAPK4 TNF 16080915 1442770 Comparative gene array analysis of *induced* [MAPK] and NF-kappaB signaling pathways between retinal ganglion cells and glial cells . Positive_regulation MAPK4 TNF 16140562 1499256 These results suggested that TNFalpha induced both cell survival and apoptosis pathways in ameloblastoma and potential of TNFalpha in inducing apoptosis can be improved by inhibiting *induced* Akt and p44/42 [mitogen activated protein kinase (MAPK)] cell survival pathways . Positive_regulation MAPK4 TNF 16275991 1480306 Angiotensin II , , or epidermal growth factor *induced* [MAPK] phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation MAPK4 TNF 16291729 1526073 *Activation* of [MAPK] and Akt by anti-HER2/neu inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation MAPK4 TNF 16314440 1487002 treatment *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation in NPCs , and SB202190 , an inhibitor of p38 MAPK , blocked TNF-alpha induced chemokine production . Positive_regulation MAPK4 TNF 16325162 1511667 Furthermore , APE1/ref-1 overexpression inhibited the *induced* increase in intracellular superoxide and p38 [MAPK] phosphorylation . Positive_regulation MAPK4 TNF 16452991 1611742 Western blots showed that IL-1beta and *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK4 TNF 16517732 1530942 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of , but not IL-6 , *requires* the activity of p38 [MAPK] . Positive_regulation MAPK4 TNF 16573652 1556139 HA-mediated production *required* p38 [MAPK] , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation MAPK4 TNF 16682409 1584060 Further , the deletion of NQO1 abolished *induced* c-Jun N-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] activation . Positive_regulation MAPK4 TNF 16781693 1585618 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and and the *activation* of [MAPK] 's are potentially positive signals for IL-10 production . Positive_regulation MAPK4 TNF 16798728 1638537 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Positive_regulation MAPK4 TNF 16875982 1593565 *activates* [p38-MAPK] , a stress-responsive kinase implicated in contractile depression and cardiac injury . Positive_regulation MAPK4 TNF 16875982 1593579 Under conditions of constant coronary flow , the [p38-MAPK] activation and contractile depression *induced* by , though attenuated , remained sensitive to the absence of MKK3 or the presence of SB203580 . Positive_regulation MAPK4 TNF 16875982 1593593 *activates* [p38-MAPK] in the intact heart and in isolated cardiac myocytes through MKK3 . Positive_regulation MAPK4 TNF 16982923 1617365 Compared with wild-type cells , MIF-deficient cells were hyporesponsive to IL-1- and *induced* [MAPK] activity , AP-1 activity , and cellular proliferation , while NF-kappaB function was preserved . Positive_regulation MAPK4 TNF 17070777 1649838 Inhibition of Syk down-regulated *induced* p38 and p44/42 [MAPK] phosphorylation and nuclear translocation of p65 NF-kappaB . Positive_regulation MAPK4 TNF 17099067 1676203 Importantly , Dex is able to increase the expression of MKP-1 , which causes an inactivation of *induced* p38 [MAPK] and mediates inhibition of E-selectin expression . Positive_regulation MAPK4 TNF 17126899 1677676 Stimulation of ECs with *induced* rapid increases in the phosphorylation of their mitogen activated protein kinases ( MAPKs ) [ extracellular signal regulated kinase ( ERK ) , c-Jun-NH2-terminal kinase (JNK) , and p38 [MAPK] ] ; Positive_regulation MAPK4 TNF 17126905 1686553 Differential regulation of and GM-CSF *induced* activation of P38 [MAPK] in neutrophils and eosinophils . Positive_regulation MAPK4 TNF 17138860 1653549 The role of delta-PKC in mediated *activation* of [MAPK] is not known . Positive_regulation MAPK4 TNF 17138860 1653575 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 MAPK are involved in TNF antiapoptotic signaling and whether delta-PKC is a key regulator of [MAPK] *activation* by . Positive_regulation MAPK4 TNF 17138860 1653601 In human neutrophils , *activated* both p38 [MAPK] and ERK1/2 principally via TNFR-1 . Positive_regulation MAPK4 TNF 17158449 1694263 A green fluorescent protein fusion protein containing the last 100 residues of TAK1 ( TAK1-C100 ) abolished the interaction of endogenous TAB2/TAB3 with TAK1 , the phosphorylation of TAK1 , and prevented the activation of IKK and [MAPK] *induced* by IL-1 , , and RANKL . Positive_regulation MAPK4 TNF 17161959 1694541 Upon examination of the signaling components , we found that was a potent *activator* of p38 , p44/42 , p54/46 [MAPK] , and IkappaBalpha ( IkappaBalpha ) . Positive_regulation MAPK4 TNF 17172975 1679389 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the [MAPK] , and production of . Positive_regulation MAPK4 TNF 17172975 1679415 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the [MAPK] , and production of . Positive_regulation MAPK4 TNF 17189827 1680171 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Positive_regulation MAPK4 TNF 17202326 1680817 Augmented lipopolysaccharide induced production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK4 TNF 17202326 1680843 In this study , we show that augmented LPS induced production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK4 TNF 17218473 1732521 The RhoA inhibitor C3 exoenzyme and the ROCK inhibitor Y-27632 both attenuated *induced* [MAPK] activation and blocked AR expression in HIMEC . Positive_regulation MAPK4 TNF 17220297 1703056 TRAF2 and ASK1 play essential roles in *induced* [mitogen activated protein kinase] signaling . Positive_regulation MAPK4 TNF 17258890 1725458 The effects of and FasL on GrB expression were specifically *mediated* by [p38MAPK] ( Mitogen-activated-protein-kinase ) activation . Positive_regulation MAPK4 TNF 17425653 1748786 The percentage increases in IL-18 induced phosphorylation of extracellular signal regulated kinase ( ERK ) in Th cells of NDN and DN were significantly higher than controls ( P < 0.05 ) , while the percentage increase in *induced* phosphorylation of p38 [MAPK] in monocytes and IL-18 induced phosphorylation of p38 MAPK in Th cells and monocytes were significantly higher in NDN patients than controls . Positive_regulation MAPK4 TNF 17438131 1742779 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation MAPK4 TNF 17438336 1749078 FAK promoted *stimulated* [MAPK] activation needed for maximal IL-6 production . Positive_regulation MAPK4 TNF 17438336 1749101 Analysis of FAK ( -/- ) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity , Tyr-397 phosphorylation , and the Pro-712/713 proline-rich region of FAK were required for *stimulated* [MAPK] activation and IL-6 production . Positive_regulation MAPK4 TNF 17446186 1749513 *increased* p38 [MAPK] phosphorylation , potently stimulated IRS-1 serine phosphorylation , and blunted insulin stimulated IRS-1 tyrosine and Akt phosphorylation and eNOS activity . Positive_regulation MAPK4 TNF 17531219 1762173 On the other hand , aloe emodin did not affect induced *activation* of p38 [mitogen activated protein kinase] or generation of reactive oxygen species . Positive_regulation MAPK4 TNF 17607712 1798192 Although *induced* the activation of p38 [MAPK] , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation MAPK4 TNF 17725582 1801637 MAC inhibited induced p38 [mitogen activated protein kinase] *activation* and cell death in cultured Schwann cells . Positive_regulation MAPK4 TNF 17895408 1823968 IA did not interfere with *induced* activation of c-Jun N-terminal kinase (JNK) and p38 [mitogen activated protein kinase] . Positive_regulation MAPK4 TNF 17942934 1814217 Deletion of NQO2 also abolished *induced* c-Jun NH2-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] activation . Positive_regulation MAPK4 TNF 17994109 1851165 triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 [MAPK] , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation MAPK4 TNF 18039275 1828531 Further downstream in this axis of signalling , blockade *reduces* only acute bronchoconstriction , while [MAPK] inhibition abrogates completely endotoxin induced inflammation . Positive_regulation MAPK4 TNF 18060043 1853605 In cultures of Schwann cells , astrocytes , and microglia , sLRP-alpha inhibited *induced* activation of p38 MAPK and [ERK/MAPK] . Positive_regulation MAPK4 TNF 18061162 1861519 We demonstrate that *induced* proliferation of C4HD murine mammary tumor cells and of T47D cells through the activation of p42/p44 [MAPK] , JNK , PI3-K/Akt pathways and nuclear factor-kappa B (NF-kappa B) transcriptional activation . Positive_regulation MAPK4 TNF 18091748 1847370 *induced* phosphorylation of extracellular signal regulated kinase ( ERK ) and Akt , but not p38 [mitogen activated protein kinase (MAPK)] , was attenuated by nicardipine , cilnidipine , benidipine , efonidipine , and azelnidipine . Positive_regulation MAPK4 TNF 18227157 1884370 It was shown that these three proteins could ( i ) induce expression of and tissue factor and ( ii ) *induce* phosphorylation of p44/42 [mitogen activated protein kinases (MAPK)] and activation of early growth response factor 1 (Egr-1) . Positive_regulation MAPK4 TNF 18258304 1884799 However , over-expression of a dominant negative form of Rac strongly inhibited induced p42/44 [MAPK] kinase *activation* , but had little effect upon JNK and no effect upon p38 MAPK activity . Positive_regulation MAPK4 TNF 18287053 1872492 Here , we show that the murine CMV M45 protein binds to RIP1 and inhibits *induced* activation of NF-kappaB , p38 [MAPK] , and caspase independent cell death . Positive_regulation MAPK4 TNF 18287248 1896528 Flavopiridol suppresses induced *activation* of activator protein-1 , c-Jun N-terminal kinase , p38 [mitogen activated protein kinase (MAPK)] , p44/p42 MAPK , and Akt , inhibits expression of antiapoptotic gene products , and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells . Positive_regulation MAPK4 TNF 18314542 1931909 P < 0.05 ) , and MKP-1 up-regulation was temporally related to the inhibition of *induced* p38 [MAPK] phosphorylation . Positive_regulation MAPK4 TNF 18336852 1912243 *stimulated* phosphorylation of p42/p44 [MAPK] and JNK were attenuated by pretreatment with the inhibitors U0126 and SP600125 or transfection with dominant negative mutants of DeltaERK and DeltaJNK . Positive_regulation MAPK4 TNF 18364436 1912771 We , for the first time , demonstrate that binding of staphylococcal enterotoxin B to MHC-II results in activation of TNF-alpha converting enzyme , epidermal growth factor receptor , [p38MAPK] , and NF-kappaB *inducing* biphasic production . Positive_regulation MAPK4 TNF 18443205 1938529 Conversely , *induced* increases in insulin receptor substrate-1 serine phosphorylation ( Ser ( 312 ) ) , Jun NH ( 2 ) -terminal kinase phosphorylation , and extracellular signal related kinase-1/2 [mitogen activated protein kinase (MAPK)] phosphorylation were unaltered by siRNA mediated IKKbeta reduction . Positive_regulation MAPK4 TNF 18518937 1971923 Although Cot/Tpl2 was phosphorylated in IRI and in the cultured tubular epithelial cells (TEC) after stimulation with LPS and hydrogen peroxide , there were no significant differences in terms of production , neutrophil infiltration or [MAPK] *activation* between Cot/Tpl2 ( +/+ ) and Cot/Tpl2 ( -/- ) mice . Positive_regulation MAPK4 TNF 18636175 1937273 Furthermore , glucosamine inhibited the *induced* phosphorylation of [p38MAPK] and NF-kappaB p65 , and the nuclear translocation of NF-kappaB in the cells . Positive_regulation MAPK4 TNF 18653803 1960520 PMA stimulated nSMase2 translocation was independent of p38 MAPK , and neither PKC inhibitors nor small interfering RNA had significant effects on *stimulated* p38 [MAPK] activation , indicating that PKC-delta does not act through p38 MAPK in regulating nSMase2 . Positive_regulation MAPK4 TNF 18710428 2028204 As for the signalling pathway , stimulation *led* to the phosphorylation of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and translocation of nuclear factor kappaB (NF-kappaB) ( p65 ) into the nuclei . Positive_regulation MAPK4 TNF 18710428 2028229 These data suggest that interaction *leads* to the phosphorylation of Erk1/2 and [p38MAPK] and nuclear translocation of NF-kappaB , which is closely associated with the production and activation of MMP-9 in cultured CC cells of HuCTT-1 and CCKS-1 . Positive_regulation MAPK4 TNF 18768892 1957228 Consistently , Nod2-null macrophages tolerant to LPS and MDP showed enhanced production of and IL-6 as well as increased NF-kappaB and [MAPK] *activation* in response to the dipeptide KF1B , the Nod1 agonist . Positive_regulation MAPK4 TNF 18948845 2053243 Hypertonic saline did not alter *induced* p38 [mitogen activated protein kinase] phosphorylation or constitutive vascular endothelial growth factor expression , suggesting that the observed inhibition is not a generalized suppression of protein phosphorylation or cellular function . Positive_regulation MAPK4 TNF 19100731 2031224 at 30 ng/ml significantly *increased* phosphorylation of receptor tyrosine kinase ( 175 kDa ) and p42 [mitogen activated protein (MAP) kinase] . Positive_regulation MAPK4 TNF 19130554 2025303 Stimulation of HIMEC with *triggered* phosphorylation of the [MAPK] , and up-regulation of VCAM-1 , FKN and ICAM-1 . Positive_regulation MAPK4 TNF 19234337 2079513 Analysis of downstream signals showed that inhibition of NAD(P)H oxidase partially inhibited NF-kappaB activation but did not reduce CCL2 mRNA stability or prevent *induced* phosphorylation of [p38MAPK] . Positive_regulation MAPK4 TNF 19275968 2072847 *stimulated* the phosphorylation levels of p38 [MAPK] , JNK , ERK1/2 and Akt in vascular endothelial cells . Positive_regulation MAPK4 TNF 19289468 2073041 The requirement for MADD was highly specific for *induced* activation of [MAPK] but not the related JNK and p38 kinases . Positive_regulation MAPK4 TNF 19371952 2081765 Of note , the IFN-gamma plus *stimulated* activation of p38 [MAPK] was suppressed following incubation with forskolin or DBcAMP alone . Positive_regulation MAPK4 TNF 19410630 2089698 By transfection of TAK1 siRNA , *induced* phosphorylation of IkappaBalpha , JNK1/2 , and [p38MAPK] , as well as IL-6 or IL-8 expression , were repressed . Positive_regulation MAPK4 TNF 19427347 2106797 *induced* the phosphorylation of p38 [mitogen activated protein (MAP) kinase] , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation MAPK4 TNF 19429670 2106869 Ang II and clearly *enhanced* ERK and [p38MAPK] phosphorylation . Positive_regulation MAPK4 TNF 19563733 2122011 Finally , EZS inhibited *induced* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phosphorylation . Positive_regulation MAPK4 TNF 19648110 2138334 This correlates with reduced *stimulated* p38 [MAPK] phosphorylation . Positive_regulation MAPK4 TNF 19648110 2138349 Repression of *induced* p38 [MAPK] phosphorylation , NF-kappaB dependent transcription , and IL-8 expression by dexamethasone are sensitive to transcriptional or translational inhibitors . Positive_regulation MAPK4 TNF 19648110 2138420 Thus , MKP-1 attenuates *dependent* activation of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Positive_regulation MAPK4 TNF 19648110 2138447 Small interfering RNA knockdown of dexamethasone induced MKP-1 expression partially reverses the repression of *activated* p38 [MAPK] , demonstrating that MKP-1 participates in the dexamethasone dependent repression of this pathway . Positive_regulation MAPK4 TNF 19788916 2163925 Tumor necrosis factor ( ) and H ( 2 ) O ( 2 ) *activate* [mitogen activated protein kinase (MAPK)] in SH-SY5Y cells within 5 min and this activation is completely blocked by DLPC ( 12 microM ) . Positive_regulation MAPK4 TNF 19877072 2160714 CpdA also displayed profound effects on *induced* [MAPK] activation . Positive_regulation MAPK4 TNF 19877072 2160731 In sharp contrast , DEX did not affect *induced* IKK phosphorylation , IkappaBalpha degradation , p65 nuclear translocation , or [MAPK] activation in RA FLS . Positive_regulation MAPK4 TNF 19889458 2197306 Calpain inhibition induces random migration in TNF-alpha stimulated cells and prevents the generation of reactive oxygen species , but does not alter mediated *activation* of p38 [MAPK] and ERK MAPK . Positive_regulation MAPK4 TNF 20231691 2237861 TNF-alpha treatment resulted in the phosphorylation of p38 MAPK and its downstream target , MAPK activated protein kinase-2 , but IFN-gamma did not affect the levels of [MAPK] and MAPK activated protein kinase-2 phosphorylation *induced* by . Positive_regulation MAPK4 TNF 20489729 2327423 *induced* activation of p38 [MAPK] and the production of inducible nitric oxide synthase were suppressed in ASK1-deficient Müller glial cells . Positive_regulation MAPK4 TNF 20646342 2292552 Effects of budesonide on P38 [MAPK] activation , apoptosis and IL-8 secretion , *induced* by and Haemophilus influenzae in human bronchial epithelial cells . Positive_regulation MAPK4 TNF 20646342 2292580 induced a significant *increase* in p38 [MAPK] phosphorylation . Positive_regulation MAPK4 TNF 20693316 2351481 In four of the six donors , basal and *induced* ERK and p38 [MAPK] activation were higher in ASMA than ASMNA cells . Positive_regulation MAPK4 TNF 20696856 2351512 Surprisingly , replenishment with exogenous GSH normalizes both *dependent* NF-?B as well as [MAPK] signaling and rescues hepatocytes from FKB induced death . Positive_regulation MAPK4 TNF 20951126 2364965 Taken together , this study provided first evidence demonstrating that TRAIL- , , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK4 TNF 21123734 2377725 The ability of CO to inhibit *induced* ERK1/2 and p38 [MAPK] activities in an Akt dependent manner appears to be the key element in ROS dependent survival of endothelial cells during TNF-a mediated brain inflammatory disease . Positive_regulation MAPK4 TNF 21181166 2499615 IL-1ß and *activated* the intracellular mitogen activated protein kinases ( MAPKs ) : p44/42 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) as well as nuclear factor-?B ( NF-?B ) in osteoblasts . Positive_regulation MAPK4 TNF 21285293 2425730 Inhibitors of NADPH oxidase and/or p47phox siRNA diminished ROS production and COX-2 expression as well as phosphorylation of p38 [mitogen activated protein kinase] ( p38MAPK ) and Akt *mediated* either by AS serum or by . Positive_regulation MAPK4 TNF 21336587 2457992 Effects of preconditioning with sevoflurane on *induced* permeability and activation of p38 [MAPK] in rat pulmonary microvascular endothelial cells . Positive_regulation MAPK4 TNF 21422246 2416771 Interestingly , all PHA-L ( high ) DCs displayed a strongly reduced responsiveness to induced [p38-MAPK] *activation* compared with PHA-L ( low ) DCs , indicating differences in PHA-L binding capacities between DCs with different inflammatory properties . Positive_regulation MAPK4 TNF 21422246 2416785 Moreover , hybrid-type , but not complex-type , N-glycans are required for induced [p38-MAPK] *activation* and subsequent phenotypic maturation of BMDCs ( MHC-II , CD86 , CCR7 upregulation ) . Positive_regulation MAPK4 TNF 21520062 2423124 Here , we report that *induced* cPLA(2) protein and mRNA expression , PGE ( 2 ) production , and phosphorylation of p42/p44 MAPK , p38 [MAPK] , and JNK1/2 , which were attenuated by pretreatment with a ROS scavenger [ N-acetyl-L-cysteine , ( NAC ) ] and the inhibitors of NADPH oxidase [ apocynin (APO) and diphenyleneiodonium chloride ( DPI ) ] , MEK1/2 ( U0126 ) , p38 MAPK ( SB202190 ) , and JNK1/2 ( SP600125 ) or transfection with siRNA of Nox2 , p47(phox) , MEK1 , p42 , p38 , or JNK2 . Positive_regulation MAPK4 TNF 21545687 2554383 significantly *induced* phosphorylation of p38 [MAPK] , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation MAPK4 TNF 21894146 2510879 Vehicle and untreated NTN exhibited heavy proteinuria and glomerular thrombosis at 24 h with P-selectin and fibrin immunostaining within capillaries , glomerular macrophage and T cell infiltration , *activation* of JNK and p38 [MAPK] signalling , and upregulation of glomerular mRNA levels of pro-inflammatory molecules ( , NOS2 , MMP-12 and CCL2 ) . Positive_regulation MAPK4 TNF 22002864 2526330 These results suggest that H ( 2 ) O ( 2 ) -induced secretion of *increases* apoptosis of cardiac myocytes through ROS dependent activation of p38 [MAPK] . Positive_regulation MAPK4 TNF 22227193 2544579 Casuarinin significantly inhibited *induced* activation of NF-?B , STAT1 , and p38 [MAPK] . Positive_regulation MAPK4 TNF 22230399 2519479 KMUP-1 inhibited *induced* iNOS and U46619 induced PDE-5A and phospho-p38 [MAPK] in normoxia , confirming its anti-proinflammatory action . Positive_regulation MAPK4 TNF 22250084 2551214 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Positive_regulation MAPK4 TNF 22343222 2617823 Using immunohistological techniques , we showed a higher epithelial expression of , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator [protein-1/mitogen activated protein kinase] signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation MAPK4 TNF 22525504 2522575 *up-regulated* the phosphorylation levels of p38 [MAPK] and increased the translocation of NF-kB p65 protein into the nucleus , also proved by immunofluorescence staining . Positive_regulation MAPK4 TNF 22526394 2595916 also *increased* the production of inducible nitric oxide synthase (iNOS) , nitric oxide ( NO ) , and intercellular adhesion molecule 1 ( ICAM-1 ) through activation of p38 [mitogen activated protein kinase (MAPK)] from HT-29 cells . Positive_regulation MAPK4 TNF 22773691 2659905 *induced* activation of p38 [MAPK] and NF-?B was attenuated by miR-140-3p mimic . Positive_regulation MAPK4 TNF 22819264 2646098 CORM-2 inhibited *induced* activation of p38 [MAPK] , ERK1/2 , JNK , and NF-?B signaling pathways in HUVECs . Positive_regulation MAPK4 TNF 22947346 2678664 *induced* phosphorylated p38 [mitogen activated protein kinase] levels were increased in ASMCs from patients with severe asthma compared with those from patients with nonsevere asthma and nonasthmatic subjects , whereas TNF-a induced phosphorylated c-Jun N-terminal kinase and phosphorylated extracellular signal related kinase levels were increased in all asthmatic groups . Positive_regulation MAPK4 TNF 22988345 2674358 The EGF receptor and HER2 participate in *dependent* [MAPK] activation and IL-8 secretion in intestinal epithelial cells . Positive_regulation MAPK4 TNF 22988345 2674386 As the epidermal growth factor receptor (EGFR) is a known transducer of proliferative signals and a potent activator of MAPKs , we hypothesized that the EGFR participates in *dependent* [MAPK] activation and IL-8 secretion by intestinal epithelial cells ( IECs ) . Positive_regulation MAPK4 TNF 23071098 2720911 Mixed-effects modeling analysis of our data was vital for ascertaining that IL-1a and TGF-a treatment increased the activities of more pathways than IL-6 and TNF-a and that TGF-a and *increased* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phospho-protein levels in a synergistic manner . Positive_regulation MAPK4 TNF 23142559 2722789 Western blot analysis revealed that pilocarpine and physostigmine enhanced the *induced* phosphorylation of ERK1/2 and p38 [MAPK] and the degradation of I?Ba . Positive_regulation MAPK4 TNF 23333920 2758387 Interestingly , IL-27 promoted the basal and enhanced *induced* phosphorylation of p38 [MAPK] and Akt , but not I?Ba . Positive_regulation MAPK4 TNF 23353699 2754243 We further demonstrated that markedly *stimulated* p38 MAPK , p42/p44 [MAPK] , and JNK1/2 phosphorylation via a c-Src/EGFR , PDGFR/PI3K/Akt pathway . Positive_regulation MAPK4 TNF 23354775 2770527 p38a [mitogen activated protein kinases (MAPK)] may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , , interleukin-1ß , and oxidative stress . Positive_regulation MAPK4 TNF 23664593 2838386 sFGL2 secretion by CD4 ( + ) T cells can be *induced* with and IFN-? stimulation through [MAPK] signaling in renal allograft AR . Positive_regulation MAPK4 TNF 23861542 2817245 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Positive_regulation MAPK4 TNF 23884101 2821471 Furthermore , P. vulgaris extract suppressed *induced* phosphorylation of p38 [mitogen activated protein kinase (MAPK)] and extracellular signal regulated kinase ( ERK ) . Positive_regulation MAPK4 TNF 23935096 2840771 In contrast , loss of SK1 prevented *induced* phosphorylation of p38 [MAPK] , and inhibition of p38 MAPK , like SK1 knockdown , also potentiates RANTES induction . Positive_regulation MAPK4 TNF 24069158 2846996 We showed that markedly *stimulated* p42/p44 [MAPK] , p38 MAPK , and JNK1/2 phosphorylation which were attenuated by their respective inhibitors . Positive_regulation MAPK4 TNF 24080497 2902542 Consistently , DUSP1 promotes apoptosis and decreases NF-?B activity in cells in which p38 [MAPK] is *induced* by treatment . Positive_regulation MAPK4 TNF 24089494 2848153 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed receptor 1 and *requires* activation of p38 [MAPK] , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation MAPK4 TNF 24361597 2911248 We further demonstrated that *stimulated* ERK1/2 , p38 [MAPK] , and JNK1/2 phosphorylation via a c-Src dependent PDGFR/PI3K/Akt pathway . Positive_regulation MAPK4 TNF 24378531 2911776 TRAF2 has been previously reported to be required for induced *activation* of p38 [MAPK] . Positive_regulation MAPK4 TNF 24441870 2922936 We showed that markedly *stimulated* Jak2 , PDGFR , Akt , and p42/p44 [MAPK] phosphorylation , which were attenuated by their respective inhibitors . Positive_regulation MAPK4 TNF 24441870 2922954 In addition , *induced* p42/p44 [MAPK] phosphorylation was reduced by AG1296 or LY294002 . Positive_regulation MAPK4 TNF 24441870 2922990 On the other hand , could *induce* Akt and p42/p44 [MAPK] translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation MAPK4 TNF 24446489 2912941 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Positive_regulation MAPK4 TNF 24489443 2884795 Finally , by investigating the intracellular pathways involved in promoting the VEC release of cytokines/chemokines , which are targeted by natural anti-inflammatory compounds , we documented that aLipoic acid significantly counteracted *induced* NF-?B and [p38/MAPK] activation while the effects of Ginkgo biloba appeared to be predominantly mediated by Akt . Positive_regulation MAPK4 TNF 24750790 2936578 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas and NO production *required* all three [MAPK] . Positive_regulation MAPK4 TNF 7689564 225767 *induced* activation and increased tyrosine phosphorylation of [mitogen activated protein (MAP) kinase] in human fibroblasts . Positive_regulation MAPK4 TNF 7689564 225780 induced *activation* of [MAPK] was demonstrated by its enhanced ability to phosphorylate myelin basic protein in vitro and by a characteristic shift in the electrophoretic mobility of MAPK proteins . Positive_regulation MAPK4 TNF 7722327 301760 *induces* tyrosine phosphorylation of [mitogen activated protein kinase] in adherent human neutrophils . Positive_regulation MAPK4 TNF 7722327 301786 PMN pretreatment with genistein , a tyrosine kinase inhibitor , inhibited the *induced* increase in tyrosine phosphorylation and [MAPK] activity . Positive_regulation MAPK4 TNF 8626494 360279 Inhibition of induced p42/p44 [mitogen activated protein kinase] *activation* by sodium salicylate . Positive_regulation MAPK4 TNF 8626494 360293 *activates* both p42 and p44 [mitogen activated protein kinases (MAPK)] in human FS-4 fibroblasts , cells for which TNF is mitogenic . Positive_regulation MAPK4 TNF 8626494 360306 We now show that *activates* p42 [MAPK] in two cell lines whose growth is inhibited by TNF . Positive_regulation MAPK4 TNF 8626494 360321 We now show that neither phorbol ester-sensitive protein kinase C nor Gialpha link TNF to p42/p44 MAPK activation , because pretreatment of FS-4 cells with phorbol ester to down-regulate protein kinase C or pretreatment with pertussis toxin to block Gialpha does not inhibit p42/p44 [MAPK] *activation* by . Positive_regulation MAPK4 TNF 8626494 360346 To further analyze MAPK activation in FS-4 cells , we compared p42/p44 [MAPK] *activation* by and epidermal growth factor (EGF) . Positive_regulation MAPK4 TNF 8626494 360366 Elucidation of the mechanism whereby sodium salicylate blocks *induced* p42/p44 [MAPK] activation may help to clarify TNF activated signaling pathways . Positive_regulation MAPK4 TNF 8662702 367185 additionally *caused* rapid p38 and JNK-1 [mitogen activated protein kinase] activation and efficient NF-kappaB translocation , which could not be achieved even by high levels of ceramide . Positive_regulation MAPK4 TNF 9106254 424419 The increases in [MAPK] *induced* by and IL-1 were similar to the increases induced by PMA and PDGF-AB . Positive_regulation MAPK4 TNF 9106254 424445 Our findings indicate that and IL-1 activate parallel signal transduction pathways in human neuroma fibroblasts , and that they are relatively stronger *activators* of [MAPK] than of SAPK . Positive_regulation MAPK4 TNF 9315666 456103 , an inhibitor of insulin stimulated adipogenesis , *activated* [MAPK] in 3T3-L1 cells . Positive_regulation MAPK4 TNF 9439626 482872 *increased* ERK1 and ERK2 [MAPK] phosphorylation . Positive_regulation MAPK4 TNF 9439626 482898 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic effect of *requires* protein tyrosine phosphorylation and [MAPK] activation . Positive_regulation MAPK4 TNF 9593119 505488 The CAZ released endotoxin was similar to purified LPS with respect to the following biological activities in LPS-responsive C3H/HeN mice and LPS-hyporesponsive C3H/HeJ mice : lethal toxicity in GalN sensitized mice , in vitro induction of and NO production by macrophages , and [mitogen activated protein kinase] *activation* in macrophages . Positive_regulation MAPK4 TNF 9766635 538514 Our data suggest that and GM-CSF *activate* ERKs and p38 [MAPK] by different signal transduction pathways . Positive_regulation MAPK4 TNF 9770326 538805 Furthermore , *induction* of p42/p44 ERK and [p38-MAPK] phosphorylation , c-jun kinase activation , and IkappaBalpha degradation were normal . Positive_regulation MAPK4 TNF 9883899 558211 *Activation* of p42/p44 mitogen activated protein kinases (MAPK) and p38 [MAPK] by is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation MAPK4 TNF 9883899 558226 Here , we demonstrate that is *sufficient* to activate p42/p44 [MAPK] and p38 MAPK . Positive_regulation MAPK4 TNF 9930718 588840 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Positive_regulation MAPK4 TNF 9931102 588907 ( 100 U/mL ) transiently *activated* [MAPK] with a maximal induction 10 minutes after stimulation that returned to baseline levels by 2 hours after treatment . Positive_regulation MAPK4 TNF 9931102 588920 PD98059 also blocked *stimulated* [MAPK] activation in a concentration dependent manner , which is consistent with its inhibition of TNF-alpha directed migration . Positive_regulation MAPK4 TNF 9931102 588933 To identify which TNF-alpha receptor is involved in *induced* [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Positive_regulation MAPK4 TNF 9931102 588959 VSMC express both receptors , but induced [MAPK] *activation* was inhibited only by the TNF-R1 antibody . Positive_regulation MAPK4 TNF 9931102 588985 Both TRO and RSG inhibited migration , but neither attenuated *induced* [MAPK] activation , indicating that their antimigration activity was exerted downstream of MAPK . Positive_regulation MAPK4 TNFSF10 12969966 1185574 Among the intracellular pathways investigated , significantly *stimulated* the extracellular signal regulated kinase 1/2 ( ERK1/2 ) but not the [p38/mitogen activated protein kinase (MAPK)] or the c-Jun NH2-terminal kinase (JNK) pathway . Positive_regulation MAPK4 TNFSF10 20951126 2364966 Taken together , this study provided first evidence demonstrating that , TNF-a- , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK4 TNFSF10 21152872 2373396 Taken together , we show herein that the upstream molecule of the induced [MAPK] *activation* is MEKK , as opposed to ASK1 , via the mediation of its signal through JNK/p38 in a caspase-8 dependent manner . Positive_regulation MAPK6 ADRB2 11018034 752793 induced p38 [MAPK] *activation* is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes . Positive_regulation MAPK6 ADRB2 12509508 1038748 beta-Arrestin 1 is required for internalization and [mitogen activated protein (MAP) kinase] *activation* by the . Positive_regulation MAPK6 ADRB2 19047375 2023487 Hematopoietic protein tyrosine phosphatase mediates *induced* regulation of p38 [mitogen activated protein kinase] in B lymphocytes . Positive_regulation MAPK6 ADRB2 9038193 415368 In the present work , we report that stimulation of the A2A-adenosine receptor and of the *activates* [mitogen activated protein kinase] ( MAP kinase ) in human endothelial cells based on the following criteria : adenosine analogues and beta-adrenergic agonists cause an ( i ) increase in tyrosine phosphorylation of the p42 isoform and to a lesser extent of the p44 isoform of MAP kinase and ( ii ) stimulate the phosphorylation of myelin basic protein by MAP kinase; (iii) this is accompanied by a redistribution of the enzyme to the perinuclear region . Positive_regulation MAPK6 ADRB2 9363896 462911 We show that in HEK293 cells , *stimulation* of [mitogen activated protein (MAP) kinase] by the is mediated by the betagamma subunits of pertussis-toxin-sensitive G proteins through a pathway involving the non-receptor tyrosine kinase c-Src and the G protein Ras . Positive_regulation MAPK6 ALOX5 11807011 903511 In contrast , stress induced product formation and translocation of <5-LO> , as well as *activation* of p38 [MAPK] , occurred also after Ca ( ++ ) depletion . Positive_regulation MAPK6 ALOX5 21200133 2391694 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Positive_regulation MAPK6 ANGPT1 12039842 954284 Accordingly , ephrinB2 inhibited VEGF- and *induced* [Ras-MAPK] activities , whereas ephrinB2 did not alter VEGF induced Flk phosphorylation or Ang1 induced Tie2 phosphorylation . Positive_regulation MAPK6 ANGPT1 12213710 985649 Both VEGF and *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 [MAPK] . Positive_regulation MAPK6 ANGPT1 12213726 985719 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of and Ang-2 as well as the *activation* of [MAPK] , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation MAPK6 ANGPT1 16061664 1439072 *activated* [mitogen activated protein kinase (MAPK)] and phosphoinositide 3-kinase (PI3K) in IBE cells and HUVECs . Positive_regulation MAPK6 ANGPT1 16679392 1612156 Pretreatment with either DPI or apocynin also significantly attenuated *induced* Akt and p44/42 [MAPK] phosphorylation . Positive_regulation MAPK6 ANGPT1 16679392 1612172 Using mouse heart microvascular endothelial cells from wild-type ( WT ) mice and mice deficient in the p47(phox) component of NADPH oxidase ( p47 ( phox-/- ) ) , we found that although *stimulated* intracellular ROS , Akt and p42/44 [MAPK] phosphorylation , and cell migration in WT cells , the responses were strikingly suppressed in cells from the p47 ( phox-/- ) mice . Positive_regulation MAPK6 ANGPT1 20072135 2235290 *promoted* skin cell metabolism/viability , adhesion , and akt and [MAPK] ( p42/44 ) activations . Positive_regulation MAPK6 ANO1 22564524 2619165 *induces* [MAPK] and contributes directly to tumorigenesis and cancer progression . Positive_regulation MAPK6 CAPN8 21543591 2424159 Downstream , an Aß-mediated rise in p38 [mitogen activated protein kinase (MAPK)] activation was followed by downregulation of cAMP response element binding protein , and LTP impairment was *prevented* by inhibitors of p38 MAPK or . Positive_regulation MAPK6 CAPN8 24416390 2901027 Treatment with glutamate leads to early activation of NMDAR , which in turn leads to mediated cleavage of striatal enriched protein tyrosine phosphatase ( STEP ) and subsequent *activation* of p38 [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK6 CCL17 23711854 2792906 IL-33 induced the production of thymus and activation regulated and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 [MAPK] . Positive_regulation MAPK6 CCND1 11004713 735022 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping [ERK-MAPK] activation and c-Fos and *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation MAPK6 CCND1 12654183 1072987 [MAPK] may *induce* overexpression of protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation MAPK6 CCND1 15634644 1349557 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 [mitogen activated protein kinase] , and down-regulation of . Positive_regulation MAPK6 CCND1 16522728 1531461 We conclude that incretin induced beta-cell replication is dependent on cAMP/PKA , p42 [MAPK] and PI3K activities , which may *involve* transcriptional induction of . Positive_regulation MAPK6 CCND1 9537433 497566 Furthermore , in 25 of 26 cases of HCC which genomic DNA was available , 22 cases without genomic DNA amplification exhibited positive correlation , not only between protein expression of c-Fos and , but also between [MAPK/ERK] *activation* and cyclin D1 expression . Positive_regulation MAPK6 CD14 15625444 1349240 LPS interacts with the cell surface receptor , which generates transmembrane signals through Toll-like protein 4 *leading* to [mitogen activated protein kinase (MAPK)] p38 activation , cytokine synthesis , PMN beta2-integrin expression and oxidative burst . Positive_regulation MAPK6 CHI3L1 23755018 2797731 In addition , *induces* [FAK-MAPK] signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation MAPK6 CHI3L1 23972995 2836243 We also demonstrate that *activates* macrophage [mitogen activated protein kinase] , protein kinase B/AKT , and Wnt/ß-catenin signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation MAPK6 CLU 23051594 2702824 FOXL2 directly stimulates the Clu gene promoter , and we show that PTTG triggers ataxia telangiectasia mutated [kinase/IGF-I/p38MAPK] DNA damage/chromosomal instability signaling , which in turn also *induces* expression . Positive_regulation MAPK6 CTGF 11732999 885266 *induces* chondrocyte differentiation through a p38 [mitogen activated protein kinase] ( p38MAPK ) , and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase ( ERK ) . Positive_regulation MAPK6 CTGF 11732999 885280 In the proliferation phase , *induced* a approximately fivefold increase in the phosphorylation of p44/42 [MAPK/ERK] and a approximately twofold increase in that of p38 MAPK in an in vivo kinase assay . Positive_regulation MAPK6 CTGF 12218048 1012166 The inhibition of *induced* p42/44 [MAPK] or phosphatidylinositol 3-kinase (PI3K)/protein kinase B pathway activities abrogated the induction of fibronectin expression . Positive_regulation MAPK6 CTGF 16408113 1513481 *enhanced* the mRNA expression and protein release of fractalkine , MCP-1 , and RANTES , the expression of phospho ( P ) -p42/44 [mitogen activated protein kinase (MAPK)] , P-phosphoinositide 3-kinase (PI3-K) , P-Akt , and activity of nuclear factor-kappaB (NF-kappaB) in mesangial cells . Positive_regulation MAPK6 CTGF 16408113 1513517 P-p42/44 MAPK blockade inhibited the *induced* expression of P-p42/44 [MAPK] but not NF-kappaB , and partially decreased the levels of the above chemokines in supernatants . Positive_regulation MAPK6 CTGF 16522717 1531329 ( 3 ) *stimulated* dose dependent HSC adhesion and activity of p42/p44 [mitogen activated protein kinase] , the latter of which was antagonized by blocking the activity of focal adhesion kinase . Positive_regulation MAPK6 CTGF 16938382 1654128 No single module , but a mixture of the 4 modules provoked a significant activation of p38 [MAPK] in HCS-2/8 cells , which was *activated* by the full-length . Positive_regulation MAPK6 CTGF 19038999 2023091 Interestingly , CCN2-BMP-2 did not affect the *induced* phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Positive_regulation MAPK6 EDN2 12193071 980943 The molecular mechanisms of dependent *activation* of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Positive_regulation MAPK6 EDN2 12475899 1037781 *induced* a rapid phosphorylation of the [mitogen activated protein kinase (MAPK)/ERK] and increased collagen I gene activity in freshly isolated aortas . Positive_regulation MAPK6 EDN2 1280103 203048 rapidly *stimulates* [mitogen activated protein kinase] activity in rat mesangial cells . Positive_regulation MAPK6 EDN2 12855582 1149899 also *induced* the activation of p42/44 [mitogen activated protein kinase (MAPK)] in DCs . Positive_regulation MAPK6 EDN2 7509933 241615 *stimulates* [mitogen activated protein kinase] p42 activity through the phosphorylation of the kinase in rat mesangial cells . Positive_regulation MAPK6 EDN2 7849246 286739 *stimulates* [mitogen activated protein kinase] activity in mesangial cells through ETA . Positive_regulation MAPK6 EDN2 7943276 276406 has been shown to *activate* [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK6 EDN2 8836145 386180 In bovine airway smooth-muscle cells platelet derived growth factor ( PDGF ) and ( Et-1 ) *stimulate* sustained and comparable activation of [mitogen activated protein kinase] ( MAP kinase ) but display very different mitogenic efficacies , with PDGF inducing 50 times more DNA synthesis than Et-1 . Positive_regulation MAPK6 EFNB1 15502157 1347564 Further downstream of the signaling pathway , stimulation *led* to increased LAT ( linker for activation of T-cells ) phosphorylation and p44/42 and p38 [MAPK] activation . Positive_regulation MAPK6 EPHB2 10601128 574216 Tumor necrosis factor-alpha (TNF-alpha) alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only . Positive_regulation MAPK6 EPHB2 10872747 707029 Pre-treatment of the cells with PD98059 , a selective pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation MAPK6 EPHB2 11083274 750495 Tumor necrosis factor alpha , interleukin-1 (IL-1) , and IL-6 were the major inducers of , JNK , and p38 [MAPK] *activation* in cultured human synovial cells . Positive_regulation MAPK6 EPHB2 12386816 999767 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 [MAPK] and a biphasic *activation* of . Positive_regulation MAPK6 EPHB2 12403788 1036187 SB203580 , a p38 [MAPK] *inhibitor* , and PD98059 , an inhibitor , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation MAPK6 EPHB2 12486127 1056312 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain *had* little effect on basal Erk [MAPK] activation . Positive_regulation MAPK6 EPHB2 12511425 1070741 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation MAPK6 EPHB2 12801927 1120236 GE2 stimulation *induced* phosphorylation , whereas it did not alter the phosphorylation of c-Jun N-terminal kinase or p38 [MAPK] . Positive_regulation MAPK6 EPHB2 12832293 1105581 Exposure to E. coli DNA resulted in phosphorylation of ERK 1/2 [MAPK] and inhibitors of activity ( PD98059 , UO126 ) significantly *reduced* the evoked IL-8 production . Positive_regulation MAPK6 EPHB2 12878192 1115523 ( 2 ) the *activation* of JNK and p38 [MAPK] but not in embryonic fibroblasts ( MEFs ) derived from ASK1 knockout mice ( ASK1 ( -/- ) MEFs ) was depressed compared to MEFs derived from wild type mice ( ASK1 ( +/+ ) MEFs ) ; Positive_regulation MAPK6 EPHB2 14973553 1212720 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen activated protein kinase (MAPK)] signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation MAPK6 EPHB2 14998726 1216734 Furthermore , we found that PD98059 , an pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation MAPK6 EPHB2 15659876 1350315 The anabolic effect of TNF-alpha was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an . Positive_regulation MAPK6 EPHB2 16038626 1437431 SF significantly prevented Abeta induced increases in IL-1beta and p38 [MAPK] *activation* and also Abeta induced changes in and phospho-Akt/PKB expression levels . Positive_regulation MAPK6 EPHB2 17056059 1649531 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Positive_regulation MAPK6 EPHB2 17403539 1735938 Trauma-hemorrhage increased the production of IL-6 , IL-10 , IL-12 and TNF-alpha enhanced the expression of TLR4 , MyD88 as well as the *activation* of [MAPK] proteins ( p38 , and JNK ) in epidermal keratinocytes . Positive_regulation MAPK6 EPHB2 17416211 1777911 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK6 EPHB2 17464174 1731749 The mRNA and surface protein up-regulation of CCR1 and CCR2 in 9CRA stimulated cells were weakly blocked by the pretreatment of SB202190 , a p38 [MAPK] *inhibitor* , and PD98059 , an upstream inhibitor . Positive_regulation MAPK6 EPHB2 18164124 1869614 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 [MAPK] , but not by the *activation* of JNK , , and NF-kappaB pathway . Positive_regulation MAPK6 EPHB2 18266967 2000320 VEGF induced activation of p42 also *led* to the nuclear translocation of [MAPK/ERK1/2] . Positive_regulation MAPK6 EPHB2 18285354 1885410 Pre-treatment with the [MAPK] *inhibitors* SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( inhibitor ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation MAPK6 EPHB2 18338254 1938062 Interestingly , inhibition of by U0126 completely *prevented* artepillin C-induced p38 [MAPK] phosphorylation of PC12m3 cells . Positive_regulation MAPK6 EPHB2 18520049 1918677 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of , rather than by the *activation* of p38 [MAPK] , in the spinal cord . Positive_regulation MAPK6 EPHB2 18982426 2105751 These inhibitory effects were partially inhibited by SB203580 , a specific *inhibitor* of p38 [MAPK] , but not by PD98059 , a specific inhibitors of extracellular signal regulated kinase ( ) , and SP600125 , a specific inhibitor of c-Jun-N-terminal kinase (JNK) . Positive_regulation MAPK6 EPHB2 19189219 2113966 Moreover , EM1 treatment resulted in less activation of p38 [MAPK] and more *activation* of signaling in lipopolysaccharide stimulated DCs . Positive_regulation MAPK6 EPHB2 19276187 2051422 Treatment of cells with sphingosine induced suppression of and *activation* of p38 [MAPK] . Positive_regulation MAPK6 EPHB2 19429670 2106925 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either inhibitor , [p38MAPK] *inhibitor* or NF-kappaB inhibitor . Positive_regulation MAPK6 EPHB2 19522739 2103145 Treatment with [MAPK] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation MAPK6 EPHB2 19672126 2168075 A scratch wound assay of healing rates in SV40 immortalized human corneal epithelial cell line ( HCEC ) evaluated the relative contributions by p38 and and JNK [MAPK] signaling *activation* to wound healing . Positive_regulation MAPK6 EPHB2 20025124 2175517 Prior treatment of the cells with PD98059 , an kinase inhibitor or SB203580 , a [p38MAPK] *inhibitor* , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation MAPK6 EPHB2 20554538 2327626 The HNE enhanced Sp1 and NF-?B activities were attenuated by SB203580 , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , and PD98059 , an extracellular signal regulated kinase ( ) inhibitor , respectively . Positive_regulation MAPK6 EPHB2 21126656 2355803 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 [mitogen activated protein kinase] , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by . Positive_regulation MAPK6 EPHB2 21311676 2360038 Treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation MAPK6 EPHB2 21488184 2417977 Dexmedetomidine induced phosphorylation of JNK and p38 [MAPK] in rat aortic SMCs , but did not *induce* phosphorylation of . Positive_regulation MAPK6 EPHB2 21586573 2449670 Incubation of T cells with ESAT-6 induced phosphorylation and increased functional p38 [MAPK] activity , but not *activation* of or JNK . Positive_regulation MAPK6 EPHB2 21599960 2445734 In the present studies , induction of central sensitization as indicated by spinal dorsal horn [MAPK] *activation* , specifically and p38 phosphorylation , was assessed in the MIA-OA model . Positive_regulation MAPK6 EPHB2 23394443 2713244 When compared to hamsters bearing tumors that remained on the control diet , the buccal pouches of hamsters bearing tumors receiving turmeric showed the following results : ( 1 ) decreased cell proliferation ( diminished PCNA , cyclin D1 , and Bcl-2 ) and PCNA labelling index , ( 2 ) enhanced apoptosis ( increased Bax , caspase-3 , caspase-9 , and cytochrome c , and decreased survivin ) and apoptotic index , ( 3 ) decreased inflammation ( decreased Cox-2 ) , and ( 4 ) decreased [MAPK] *activation* ( and p-p38 ) . Positive_regulation MAPK6 EPHB2 23892041 2830339 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three [MAPK] *inhibitors* ( inhibitor PD98059 , JNK inhibitor SP600125 and p38 inhibitor SB203580 ) . Positive_regulation MAPK6 EPHB2 23914844 2840575 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 [MAPK] and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of , JNK , NF-?B . Positive_regulation MAPK6 EPHB2 23917355 2826043 Inhibition of Akt or activity *reduced* phosphorylation of STAT1 in Colon26L5-CUG2 cells whereas inhibition of p38 [MAPK] did not significantly decrease levels of STAT1 phosphorylation , indicating that cell proliferation signals may be involved in CUG2 mediated activation of STAT1 . Positive_regulation MAPK6 EPHB2 24225419 2897499 Therefore , by using the [MAPK] *inhibitors* SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific inhibitor ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation MAPK6 EPHB2 24297112 2894227 Following treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation MAPK6 F2R 16052512 1460029 The p38 and ERK1/2 [MAPK] signaling cascades were also *activated* by stimulation , whereas the SAPK/JNK pathway was unaffected . Positive_regulation MAPK6 F2R 16467309 1548161 and PAR-2 stimulation rapidly *activated* both ERK1/2 and [p38MAPK] , and pharmacological blockade of MEK with either PD98059 or U0126 or of p38MAPK by SB203580 or SB202190 strongly inhibited thrombin- and SLIGKV induced COX-2 expression and 6-keto-PGF1alpha formation . Positive_regulation MAPK6 F2R 21252088 2402889 In the present study , we show that FVIIa , upon binding to EPCR on endothelial cells , activates endogenous protease activated receptor-1 (PAR1) and induces mediated p44/42 [mitogen activated protein kinase (MAPK)] *activation* . Positive_regulation MAPK6 F2R 24052258 2867020 However , the distinct non-canonical tethered ligands unmasked by neutrophil elastase and proteinase-3 , as well as synthetic peptides with sequences derived from these novel exposed tethered ligands , selectively stimulated mediated [mitogen activated protein kinase] *activation* . Positive_regulation MAPK6 F2R 8635212 357973 These results support the notion that the *activates* [MAPK] through PKC dependent pathways and that the incremental activation of MAPK by TRAP over that induced by thrombin is the consequence of enhanced activation through the PKC limb of the phosphoinositide lipid pathway . Positive_regulation MAPK6 FAS 14576831 1156609 A more physiological inhibitor , the intracellular PP2A inhibitor protein I2 ( PP2A ) , protected transfected HeLa cells in a similar way from *mediated* apoptosis and induced activation of [MAPK] in I2 ( PP2A ) transfected cells . Positive_regulation MAPK6 FAS 15280387 1302536 We further demonstrate that this pro-apoptotic effect of CO was independent of reactive oxygen species production and involved inhibition in induced *activation* of the pro-survival ERK [MAPK] . Positive_regulation MAPK6 FAS 16507991 1529643 Here we show that binding of Fas ligand to *activates* p38 [MAPK] in CD8+ T cells and that activation of this pathway is required for Fas mediated CD8+ T-cell death . Positive_regulation MAPK6 FAS 19417161 2179814 GST-MDA-7 killing was , in parallel , dependent on inactivation of extracellular signal regulated kinase 1/2 and on *induced* p38 [mitogen activated protein kinase] and c-jun NH ( 2 ) -terminal kinase-1/2 signaling . Positive_regulation MAPK6 FAS 21613257 2454280 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Positive_regulation MAPK6 FAS 21975294 2492847 Caspase-8 activity has an essential role in mediated [MAPK] *activation* . Positive_regulation MAPK6 FAS 8977313 403350 IFN-alpha2 did not alter the *induced* activity of [Mitogen activated protein kinase (MAPK)] 1 and did not inhibit the Apo-1/Fas mediated proteolytic cleavage of ADP-ribosyltransferase , a substrate of Interleukin-beta1 converting enzyme ( ICE ) and homologues . Positive_regulation MAPK6 FHL1 23456229 2781821 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Positive_regulation MAPK6 FOXA1 22879989 2641686 An increase in IGFBP-3 , mediated by depletion of , *inhibited* phosphorylation of [MAPK] and Akt , and increased expression of the cell cycle regulators p21 and p27 . Positive_regulation MAPK6 FUT4 20506505 2307959 These data suggested that not only *activates* [MAPK] and PI3K/Akt signals , but also promotes the crosstalk among these signaling pathways . Positive_regulation MAPK6 GLP1R 21356521 2394819 activation by Exendin-4 ( Ex-4 ) *increased* PKA and [MAPK] activity and decreased phosphorylation of AMPK in NTS . Positive_regulation MAPK6 GPR115 10958680 725795 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK6 GPR115 11916960 945547 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK6 GPR115 9182581 435741 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on mediated *activation* of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK6 GPR115 9826186 550138 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK6 GPR132 10958680 725784 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK6 GPR132 11474113 841742 Activation of by LPC *increased* intracellular calcium concentration , induced receptor internalization , activated ERK [mitogen activated protein kinase] , and modified migratory responses of Jurkat T lymphocytes . Positive_regulation MAPK6 GPR132 11916960 945536 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK6 GPR132 9182581 435730 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on mediated *activation* of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK6 GPR132 9826186 550127 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK6 GPR87 10958680 725864 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK6 GPR87 11916960 945616 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK6 GPR87 9182581 435810 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on mediated *activation* of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK6 GPR87 9826186 550207 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK6 HBEGF 10544013 563927 also rapidly *activated* [MAPK] and induced cyclin D1 in mid-G1 with kinetics similar to TGFalpha . Positive_regulation MAPK6 HBEGF 11171084 783798 Both p42 [MAPK] activation and mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation MAPK6 HBEGF 15380451 1298484 *induced* phosphorylation of ERK , p38 [MAPK] and Akt , which were suppressed by ZD1839 . Positive_regulation MAPK6 HBEGF 17928891 1858628 We report that cellular stress with methyl-beta-cyclodextrin ( MBCD ) , a molecule that extracts membrane cholesterol and thereby disrupts the structure of lipid rafts , strongly *induces* the synthesis of ( HB-EGF ) in keratinocytes through the activation of p38 [mitogen activated protein kinase] . Positive_regulation MAPK6 HBEGF 18990151 2028927 *Activation* of [Erk/MAPK] by was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation MAPK6 HBEGF 19048624 2023720 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked [MAPK] signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 MAPK , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Positive_regulation MAPK6 HBEGF 19559571 2110508 *induced* phosphorylation of p42/p44 [MAPK] in a few minutes . Positive_regulation MAPK6 HBEGF 20739666 2345893 Moreover , *induced* a stronger and more sustained activation of both the [mitogen activated protein kinase] and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation MAPK6 HBEGF 24188029 2921110 Here , we show that *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , [Mapk/Erk] pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation MAPK6 HRH1 11959800 931445 1. Previous studies have shown that the *activates* p42/p44 [mitogen activated protein kinases (MAPK)] in DDT ( 1 ) MF-2 smooth muscle cells via a phosphatidylinositol 3-kinase (PI-3K) dependent pathway . Positive_regulation MAPK6 HRH1 17965772 1820343 is *required* for TCR mediated p38 [MAPK] activation and optimal IFN-gamma production in mice . Positive_regulation MAPK6 HRH1 17965772 1820357 Moreover , signaling at the time of TCR ligation was *required* for activation of p38 [MAPK] , a known regulator of IFN-gamma expression . Positive_regulation MAPK6 IFI27 16953232 1682590 RET2A mediated regulation of p18 and , but not of cyclins D1 and D2 , *requires* functional [mitogen activated protein kinase] signaling . Positive_regulation MAPK6 IL1B 10640438 577512 and TNF alpha also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK6 IL1B 10704772 673009 CPI-1189 inhibits *induced* [p38-mitogen activated protein kinase] phosphorylation : an explanation for its neuroprotective properties ? Positive_regulation MAPK6 IL1B 10775561 686648 *activated* p44/42 [MAPK] , and this activation was enhanced in the presence of N-acetyl-L-cysteine . Positive_regulation MAPK6 IL1B 10864897 705734 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK6 IL1B 10864897 705786 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by TNF-alpha and . Positive_regulation MAPK6 IL1B 10864897 705802 TNF-alpha- and *induced* [ ( 3 ) H ] -thymidine incorporation and phosphorylation of p42/p44 [MAPK] was completely inhibited by PD98059 ( an inhibitor of MEK1/2 ) , indicating that activation of MEK1/2 was required for these responses . Positive_regulation MAPK6 IL1B 10969830 728490 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Positive_regulation MAPK6 IL1B 11032891 740458 *induces* p38 [MAPK] phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation MAPK6 IL1B 11037878 741245 also *stimulated* phosphorylation of p38 [MAPK] , SAPK/JNK , and ATF-2 . Positive_regulation MAPK6 IL1B 11126408 759777 TNFalpha and IFNgamma potentiate *induced* [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK6 IL1B 11126408 759790 [Mitogen activated protein kinase (MAPK)] activity that is *induced* by has been suggested to signal nitric oxide dependent as well as nitric oxide independent beta-cell destructive pathways . Positive_regulation MAPK6 IL1B 11126408 759803 The aim of this study was to investigate if TNFalpha and IFNgamma signal through mitogen activated protein kinases in isolated rat islets of Langerhans and if they potentiate [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK6 IL1B 11126408 759816 Further , TNFalpha and IFNgamma were found to synergistically increase [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK6 IL1B 11399523 824264 Glucose potentiates *induced* p38 [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK6 IL1B 11509550 848374 Although and TNF-alpha each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK6 IL1B 11557585 861407 *activated* the three [mitogen activated protein kinase] ( extracellular signal regulated kinases 1 and 2 , c-Jun NH2-terminal kinase/stress activated protein kinase , and p38 ) and the Janus kinase (JAK)-signal transducer and activator of transcription pathways . Positive_regulation MAPK6 IL1B 11698472 878056 *induced* phosphorylation and activation of p38 [MAPK] and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation MAPK6 IL1B 11698472 878102 *induced* phosphorylation of ERK and JNK as well as p38 [MAPK] in human endothelial cells . Positive_regulation MAPK6 IL1B 11728947 884813 We showed a dramatic decrease in *induced* phosphorylation of p38 [MAPK] , not extracellular signal regulated kinases 1/2 or jun NH2-terminal kinase , in rat cultured mesangial cells by FR167653 . Positive_regulation MAPK6 IL1B 11775830 766441 Role of protein tyrosine kinase in *induced* activation of [mitogen activated protein kinase] in fibroblast-like synoviocytes of rheumatoid arthritis . Positive_regulation MAPK6 IL1B 11853544 913375 Interestingly , *induced* p38 [MAPK] activity was greatly enhanced in ( alg+ ) compared with ( alg- ) cells . Positive_regulation MAPK6 IL1B 12117921 964669 mRNA expression by neutrophils was not dependent on p38 MAPK , and p38 [MAPK] was not *activated* in neutrophils incubated with A. phagocytophila . Positive_regulation MAPK6 IL1B 12131776 966867 and TNF-alpha *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK6 IL1B 12139924 969400 Regarding intracellular signaling , *activated* the p38 [mitogen activated protein kinase (MAPK)] but not the p42/p44 MAPK and , when combined with growth factors , intensified p38 activation but inhibited the growth-factor induced p42/p44 activation . Positive_regulation MAPK6 IL1B 12356282 993882 induced p44/42 [mitogen activated protein kinase (MAPK)] *activation* was inhibited by the MAPK/extracellular signal regulated protein kinase ( MEK ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK6 IL1B 12417253 1012957 Sphondin ( 50 microM ) did not affect the *induced* activations of p44/42 MAPK , p38 [MAPK] , and JNK . Positive_regulation MAPK6 IL1B 12500176 1026691 These data suggest that the presence of retinal holes and may *lead* to activation of HGF , [mitogen activated protein kinases (MAPK)] , c-jun and extracellular matrix remodeling , resulting in proliferative and migratory cells in the wounded retina . Positive_regulation MAPK6 IL1B 12507586 1038425 In this study we evaluated the role of epigallocatechin-3-gallate ( EGCG ) , a green tea polyphenol which mimics its anti-inflammatory effects , in modulating the *induced* activation of [MAPK] 's in human chondrocytes . Positive_regulation MAPK6 IL1B 12649265 1080071 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant MKK6 or p38beta2 MAPK inhibited induced p38 [MAPK] *activation* , COX-2 gene expression , and PGE2 release . Positive_regulation MAPK6 IL1B 12727980 1086561 P38 [MAPK] phosphorylation was *increased* by in nondecidualized ESC , whereas the IL-1 beta induced increase was suppressed in the decidualized cells . Positive_regulation MAPK6 IL1B 12727980 1086574 Treatment with 8-bromo-cAMP reduced *induced* phosphorylation of p38 [MAPK] in nondecidualized ESC . Positive_regulation MAPK6 IL1B 12727980 1086588 In contrast , treatment with H89 , a protein kinase A inhibitor , reversed a reduction in *induced* p38 [MAPK] phosphorylation in the decidualized cells . Positive_regulation MAPK6 IL1B 12727980 1086602 The altered property of decidualized cells is thought to be caused by attenuation of *induced* p38 [MAPK] phosphorylation in a way that involves the activation of the cAMP/protein kinase A pathway . Positive_regulation MAPK6 IL1B 12882449 1116293 NAC ( 1 mM ) also decreased the induced *activation* of p38 [MAPK] . Positive_regulation MAPK6 IL1B 12952251 1137421 Using Western-blot analysis , no effect of cAMP was found on the *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK6 IL1B 12952251 1137435 No decrease was observed in *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK6 IL1B 14563491 1154864 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Positive_regulation MAPK6 IL1B 15039421 1251243 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of , and RIP2 dependent *activation* of NF-kappaB and p38 [MAPK] mediated by the caspase recruitment domain . Positive_regulation MAPK6 IL1B 15111866 1241243 We further demonstrated that p38 MAPK is activated by and PDGF with different kinetics and that p38 [MAPK] is *required* for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation MAPK6 IL1B 15208668 1281347 *induced* the activation of extracellular signal regulated kinases-1/2 and P38 [mitogen activated protein kinase (MAPK)] , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation MAPK6 IL1B 15341531 1291765 In accordance with these findings , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) , which was attenuated by U0126 , SB202190 , or SP600125 , respectively . Positive_regulation MAPK6 IL1B 15389584 1354323 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] and JNK which was attenuated by pretreatment with U0126 or SP600125 , respectively . Positive_regulation MAPK6 IL1B 15489374 1359427 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and JNK was attenuated by pretreatment with U0126 , SB-202190 , or SP-600125 , respectively . Positive_regulation MAPK6 IL1B 15755725 1403425 The inhibitory effect of on alpha ENaC expression was *mediated* by the activation of p38 [MAPK] in both rat and human ATII cells and was independent of the activation of alpha v beta6 integrin and transforming growth factor-beta . Positive_regulation MAPK6 IL1B 16033422 1436169 Intrathecal *leads* to a time dependent up-regulation of phosphorylated p38 ( p-p38 ) [MAPK] protein expression in the spinal cord 30-240 min following IL-1beta injection ( i.t. ) . Positive_regulation MAPK6 IL1B 16033422 1436183 However , pretreatment with a p38 MAPK inhibitor significantly reduced the *induced* p-p38 [MAPK] expression by 38-49 % , and nearly completely blocked the subsequent iNOS expression ( reduction by 86.6 % ) , NO production , and thermal hyperalgesia . Positive_regulation MAPK6 IL1B 16043966 1459745 Western blot analysis demonstrated that *increased* the activation of phosphorylated MEK and p38 [MAPK] in GH3 cells . Positive_regulation MAPK6 IL1B 16140882 1450809 *induced* phosphorylation of [p38-MAPK] , but not that of c-Jun-N-terminal kinase or extracellular regulated kinase , was most susceptible to inhibition by low doses of PFE , and the addition of PFE blocked the activity of p38-MAPK in a kinase activity assay . Positive_regulation MAPK6 IL1B 16141635 1454873 DHA stimulated both rapid and prolonged activation of p44/42 , but not p38 , [mitogen activated protein kinase (MAPK)] *induced* by and PMA . Positive_regulation MAPK6 IL1B 16153910 1455445 The kidney was analyzed for expression of tumor necrosis factor alpha , , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 [mitogen activated protein kinase] , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation MAPK6 IL1B 16452991 1611745 Western blots showed that and TNF-alpha *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK6 IL1B 16528573 1549432 The aim of this study was to investigate if Gadd45b prevents *induced* beta cell [MAPK] signalling and apoptosis . Positive_regulation MAPK6 IL1B 16645161 1604681 significantly *increased* the phosphorylation of p38 [MAPK] and cPLA(2) . Positive_regulation MAPK6 IL1B 16698013 1575658 JST ( 0.01-1 mg/ml ) also attenuated the expression of cyclooxygenase (COX)-2 and activation of p38 [MAPK] *induced* by and A beta ( 1-42 ) . Positive_regulation MAPK6 IL1B 16718462 1584913 A synthetic peptide , C3d , reported to bind NCAM , did not activate MAPK or Akt as reported in neurons but inhibited *induced* [MAPK] activity , thereby mimicking the effect of SU5402 . Positive_regulation MAPK6 IL1B 16718462 1584938 We suggest that NCAM signalling through FGFR is required for efficient IL-1beta pro-apoptotic signalling by facilitating *induced* [MAPK] activation downstream of the NF-kappaB-MAPK branching point . Positive_regulation MAPK6 IL1B 16718462 1584981 Further , these data identify a novel function of C3d as an inhibitor of NCAM induced FGFR activity and of induced [MAPK] *activation* in beta cells . Positive_regulation MAPK6 IL1B 16959849 1639702 *caused* an increase in the phosphorylation of ERK , but not [p38MAPK] or c-Jun N-terminal kinase . Positive_regulation MAPK6 IL1B 16964394 1611558 Inhibitors of p38 [MAPK] and/or JNK significantly suppressed VEGF secretion both in the *presence* and absence of , while inhibitors of COX-2 , ERK1/2 , and PI3-K did not . Positive_regulation MAPK6 IL1B 17208222 1695817 Thalidomide also suppressed induced p38 [mitogen activated protein kinase (MAPK)] *activation* , while a p38 MAPK inhibitor destabilized COX-2 mRNA and the cytoplasmic shuttling of HuR induced by IL-1beta . Positive_regulation MAPK6 IL1B 17311279 1719294 *stimulated* phosphorylation of p42/p44 MAPK , p38 [MAPK] , and JNK was attenuated by pretreatment with U0126 , SB202190 , SP600125 , or transfection with these dominant negative mutants of MEK , ERK , p38 and JNK , respectively . Positive_regulation MAPK6 IL1B 17390080 1716142 We have previously demonstrated that *induced* HBD-2 mRNA expression in A549 cells through activation of nuclear factor-kappaB (NF-kappaB) transcriptional factor as well as p38 [mitogen activated protein kinase (MAPK)] , c-Jun N-terminal kinase (JNK) , or phosphatidylinositol-3-kinase (PI3K) . Positive_regulation MAPK6 IL1B 17390080 1716166 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Positive_regulation MAPK6 IL1B 17390080 1716196 Triptolide inhibited *induced* [MAPK] phosphatase-1 expression at the transcriptional level and resulted in sustained phosphorylation of JNK or p38 MAPK , explaining the little effect of triptolide on IL-1beta induced phosphorylation of these kinases . Positive_regulation MAPK6 IL1B 17438131 1742782 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by TNF-alpha and , but not by ansiomycin or sorbitol . Positive_regulation MAPK6 IL1B 17559635 1753266 also *activated* extracellular signal regulated kinase , p38 [MAPK] , and c-Jun N-terminal kinase . Positive_regulation MAPK6 IL1B 17645739 1793274 Interestingly , Dex attenuated mediated *activation* of p38 [MAPK] and JNK , but not of AKT . Positive_regulation MAPK6 IL1B 17694686 1782115 IL-1beta induced NO levels and thermal hyperalgesia in rats , likely via either inhibiting the mediated p38 [MAPK] *activation* and subsequent iNOS induction , or direct attenuation of the central iNOS activity , which therefore reduces the central sensitization of inflammatory pain . Positive_regulation MAPK6 IL1B 17920534 1804194 SA981 at a concentration of 100 microM partially inhibited *induced* phosphorylation of [p38MAPK] and Akt ( 12.0 % and 36.1 % inhibition of each total amount of phosphoprotein under IL-1beta coexistence condition , respectively ) . Positive_regulation MAPK6 IL1B 17925024 1835158 *stimulated* phosphorylation of c-jun amino-terminal kinase , p38 [MAPK] and extracellular signal regulated kinase-1/2 . Positive_regulation MAPK6 IL1B 18026701 1827825 Moreover , glucosamine suppressed the *induced* phosphorylation of p38 [MAPK] ( p < 0.05 at > 0.1 mM ) and the IL-1beta binding to its receptors ( p < 0.05 at 1 mM ) . Positive_regulation MAPK6 IL1B 18065201 1853667 *stimulated* activation of ERK1/2 and p38alpha [MAPK] mediates the transcriptional up-regulation of IL-6 , IL-8 and GRO-alpha in HeLa cells . Positive_regulation MAPK6 IL1B 18348730 1925319 The *activation* or inhibition of p38 [MAPK] by and/or SB203580 was analyzed by western blotting . Positive_regulation MAPK6 IL1B 18348730 1925332 *activated* the phosphorylation of p38 [MAPK] and this effect was abolished by SB203580 . Positive_regulation MAPK6 IL1B 18427719 1920727 Phosphorylated p38 ( Phos-p38 ) [mitogen activated protein kinase] was *stimulated* in SW-1353 cells by but not by HA alone . Positive_regulation MAPK6 IL1B 18556347 1965939 or leptin individually *induced* threonine/tyrosine phosphorylation of p38 [MAPK] , whereas only leptin induced tyrosine phosphorylation of JAK2 , suggesting that leptin may enhance hBD-2 production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with NF-kappaB , which is activated by IL-1beta . Positive_regulation MAPK6 IL1B 18667841 1948056 Furthermore , induced p38 [mitogen activated protein kinase (MAPK)] *activation* and upregulation of VEGF-C mRNA and protein in LLC cells was also suppressed by artemisinin or by the p38 MAPK inhibitor SB-203580 , suggesting that p38 MAPK could serve as a mediator of proinflammatory cytokine induced VEGF-C expression . Positive_regulation MAPK6 IL1B 19362079 2081463 *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 [mitogen activated protein (MAP) kinase] , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation MAPK6 IL1B 19522843 2136343 In chondrocytes , CS diminishes *induced* increases in p38 [mitogen activated protein kinase] ( p38MAPK ) and signal regulated kinase 1/2 ( Erk1/2 ) phosphorylation , and decreases nuclear factor-kappaB (NF-kappaB) nuclear translocation and as a consequence , reduces the formation of pro-inflammatory cytokines , IL-1beta and TNF-alpha , and pro-inflammatory enzymes , such as phospholipase A2 (PLA2) , cyclooxygenase 2 (COX-2) and nitric oxide synthase-2 (NOS-2) . Positive_regulation MAPK6 IL1B 19765281 2163527 Treatment with PIP-18 blocked *induced* p38 [MAPK] phosphorylation and resulted in attenuation of sPLA2-IIA and MMP mRNA transcription in RA SF cells . Positive_regulation MAPK6 IL1B 20060906 2218525 In the present study , we demonstrate that *caused* activation of p38 [mitogen activated protein kinase] and that the p38 inhibitor SB203580 significantly blocked the effect of IL-1beta on I ( NMDA-OUT ) in hippocampal CA1 neurons . Positive_regulation MAPK6 IL1B 20353947 2266480 In model 1 , a differentiation model , CLA *activation* of [MAPK] and induction of interleukin-8 (IL-8) , IL-6 , , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation MAPK6 IL1B 21659536 2455198 Distinct roles for Nod2 protein and autocrine in muramyl dipeptide *induced* [mitogen activated protein kinase] activation and cytokine secretion in human macrophages . Positive_regulation MAPK6 IL1B 24692548 2935249 At 1 h , this was responsible for the dexamethasone inhibition of *induced* [MAPK] activation and CXCL1 and CXCL2 mRNA expression , with a similar trend for CSF2 . Positive_regulation MAPK6 IL1B 9475519 486795 Of these , *activated* only [MAPK] . Positive_regulation MAPK6 IL1B 9475519 486808 In cultured rat astrocytes , *caused* activation of [MAPK] without inducing proliferation . Positive_regulation MAPK6 IL1B 9575890 502747 Our data also indicate that both insulin and IGF-I enhance *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation and SAPK activation . Positive_regulation MAPK6 IL1B 9582321 503940 Previously we reported that *induces* activation of JNK/SAPK and p38 [MAPK] with concomitant up-regulation of cyclooxygenase (Cox)-2 expression and prostaglandin E2 ( PGE2 ) synthesis . Positive_regulation MAPK6 IL1B 9614146 509333 By Western blotting with phosphospecific antibodies and by immunocomplex kinase assay , was shown to *activate* extracellular signal regulated kinase ( ERK ) 1/2 and p38 [mitogen activated protein kinase] ( p38 ) in islets and rat insulinoma cells . Positive_regulation MAPK6 IL1B 9786861 540918 We reported previously that rapidly *activates* the c-Jun NH2-terminal/stress activated protein kinases ( JNK/SAPK ) and p38 [mitogen activated protein kinase (MAPK)] and also induces Cox-2 expression and prostaglandin E2 ( PGE2 ) production . Positive_regulation MAPK6 IL1B 9786861 540964 Overexpression of the kinase-dead form of MKK3 or MKK6 demonstrated that either of these two mutant kinases inhibited *induced* p38 [MAPK] phosphorylation and Cox-2 expression but not JNK/SAPK phosphorylation and activation . Positive_regulation MAPK6 ITGB2 12600815 1099080 IL-3 , IL-5 , and GM-CSF could enhance p38 [MAPK] and NF-kappaB activity and *induce* ICAM-1 , CD11b , and expressions on eosinophils . Positive_regulation MAPK6 ITGB2 19843511 2203205 Furthermore , beta2 integrins modulated the capacity of isolated peritoneal macrophages to take up acetylated LDL and native LDL and to phagocytose apoptotic cells , possibly via *dependent* [mitogen activated protein kinase] signalling . Positive_regulation MAPK6 LBP 20615568 2309961 Despite activating NFkappaB , NOD1 ligand did not upregulate hepatocyte production of the acute phase proteins lipopolysaccharide binding protein , serum amyloid A , or soluble CD14 in cell culture supernatants , or upregulate mRNA expression of , serum amyloid A , C-reactive protein , or serum amyloid P . NOD2 ligand ( MDP ) did not *activate* hepatocytes when given alone , but did synergize with Toll-like receptor ligands , lipopolysaccharide (LPS) , and polyI : C to activate NFkappaB and [MAPK] . Positive_regulation MAPK6 MAP2K6 10050043 592968 In one set of experiments , we *inhibited* the activation of [MAPK] by pretreating cells with PD098059 , a specific inhibitor of ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAPK6 MAP2K6 10079106 595494 Although MKK3 , MKK4 , and all *activated* p38 [MAPk] in experimental models , only MKK3 was found to activate recombinant p38 MAPk in LPS treated neutrophils . Positive_regulation MAPK6 MAP2K6 10471331 641652 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Positive_regulation MAPK6 MAP2K6 10601295 574423 In addition , *activation* of p38 [MAPK] by constitutively active or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAPK6 MAP2K6 10713051 674420 Conversely , the inhibitors PD98059 and UO126 could *attenuate* EGF induced [mitogen activated protein kinase] activation , they do not affect the EGF induced mobility shift of caveolin-1 . Positive_regulation MAPK6 MAP2K6 10759527 683187 These results demonstrate that a plant can phosphorylate and *activate* [MAPK] , and that Tyr phosphorylation is critical for the catalytic activity of MAPK in plants . Positive_regulation MAPK6 MAP2K6 10816593 714751 The MAPK kinase selectively *stimulates* p38 [MAPK] and confers protection against stress induced apoptosis in cardiac myocytes . Positive_regulation MAPK6 MAP2K6 10891559 711231 MAP kinases (MAPK) in both G-1 and G-5 cells were indistinguishably phosphorylated , yet *dependent* [MAPK] activation was observed only in G-5 cells . Positive_regulation MAPK6 MAP2K6 11005808 752458 A inhibitor , PD98059 , *inhibited* heat shock ERK [MAPK] activation by > 75 % . Positive_regulation MAPK6 MAP2K6 11085935 750742 Similarly , *activation* of JNK by Ad-MKK7D and [p38-MAPK] by resulted in the increased expression of PGHS-2 . Positive_regulation MAPK6 MAP2K6 11237743 790343 The MAPK kinase ( ) inhibitor , PD98059 , *blocked* GSA stimulated [MAPK] activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Positive_regulation MAPK6 MAP2K6 11304531 826845 The *activation* of p38 [MAPK] by Galpha ( q ) and Gbetagamma was blocked by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Positive_regulation MAPK6 MAP2K6 11787422 891965 Indeed the MAPK kinase ( = ) inhibitor PD98059 *inhibits* the activation of parasite [MAPK] , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Positive_regulation MAPK6 MAP2K6 11822870 909093 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of [MAPK] pathway *inhibitors* ( inhibitors PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAPK6 MAP2K6 12009309 940851 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Positive_regulation MAPK6 MAP2K6 12203369 983257 Furthermore , PKC inhibitors or an inhibitor completely *suppressed* both TPA induced activation of [MAPK] and promotion of anchorage independent growth , but a cPKC-selective inhibitor partially suppressed TPA induced promotion of the growth . Positive_regulation MAPK6 MAP2K6 12356282 993888 IL-1beta induced p44/42 [mitogen activated protein kinase (MAPK)] activation was *inhibited* by the MAPK/extracellular signal regulated protein kinase ( ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK6 MAP2K6 12377770 1019996 These results suggest that MKK3 , rather than , *mediates* alphav integrin induced p38 [MAPK] activation . Positive_regulation MAPK6 MAP2K6 12450322 1018675 ANG II significantly increased aldosterone release , and this effect was inhibited by the LO inhibitor baicalein , as well as a specific p38 [MAPK] *inhibitor* , SB202190 , but not by PD098059 , a specific inhibitor of the ERK activator . Positive_regulation MAPK6 MAP2K6 12637559 1085526 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Positive_regulation MAPK6 MAP2K6 12659851 1073547 MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a ( MAP2K ) , which in turn *activates* a [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK6 MAP2K6 12845643 1108627 Finally , both ODQ and UO126 blocked the capacity of L-arginine to restore ERK ( 1/2 ) phosphorylation in L-NAME treated cells , demonstrating that GC and are both *required* for endogenous NO-mediated [MAPK] activation . Positive_regulation MAPK6 MAP2K6 15104236 1240347 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( ) inhibitor , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAPK6 MAP2K6 15172888 1288424 Importantly , the presence of inhibitors only at the time of the transport assay markedly *impaired* both insulin stimulated glucose uptake and [MAPK] signaling . Positive_regulation MAPK6 MAP2K6 15172888 1288518 Conversely , removal of inhibitors before the transport assay *restored* glucose uptake and [MAPK] signaling . Positive_regulation MAPK6 MAP2K6 15304546 1322545 Furthermore , *activation* of [ERK/MAPK] by the coexpression of constitutively active predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAPK6 MAP2K6 15365248 1294603 Treatment of keratinocytes with PD98059 , inhibitor , and SB20358 , p38 [MAPK] *inhibitor* , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAPK6 MAP2K6 15570612 1355599 Although the inhibitors *suppressed* [MAPK] phosphorylation in both OA- and AICAR treated oocytes , meiotic resumption was not causally linked to MAPK phosphorylation in either group . Positive_regulation MAPK6 MAP2K6 15867183 1404247 In cultured cardiac myocytes , specific *activation* of stress activated [mitogen activated protein kinase] , p38 , by upstream activator led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAPK6 MAP2K6 15879307 1411362 Conversely , constitutively active *induced* p38 [MAPK] activation that recapitulated the effects of polyphenols by inducing ERalpha phosphorylation and downstream activation of Akt , and eNOS . Positive_regulation MAPK6 MAP2K6 16157033 1455795 SB203580 , a [P38MAPK] *inhibitor* , and U0126 , a inhibitor , both completely blocked ADM mediated responses in MsC . Positive_regulation MAPK6 MAP2K6 17416211 1777917 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK6 MAP2K6 18401006 1925870 CyaA enhanced LPS induced phosphorylation of p38 [MAPK] and ERK in DC , and inhibitors of p38 MAPK , , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation MAPK6 MAP2K6 18754769 1968471 ( MKK) 3 and 6 are the main p38 [mitogen activated protein kinase] *activators* in mammals . Positive_regulation MAPK6 MAP2K6 18771907 1962716 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a inhibitor , and SB203580 , an *inhibitor* of p38 [mitogen activated protein (MAP) kinase] , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAPK6 MAP2K6 21892182 2491667 Further , we show that *activation* of p38 [MAPK] by expression of constitutively active ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAPK6 MAP2K6 22164285 2517915 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of and marked *activation* of p38 [MAPK] . Positive_regulation MAPK6 MAP2K6 22785235 2691929 TRH induced CRE promoter was inhibited by [mitogen activated protein kinase/ERK] kinase ( MEK ) inhibitor and was *increased* by overexpression of . Positive_regulation MAPK6 MAP2K6 7644477 318700 Inhibition of by PD 098059 *prevented* activation of [MAPK] and subsequent phosphorylation of MAPK substrates both in vitro and in intact cells . Positive_regulation MAPK6 MAP2K6 7822248 285633 ( MKK ) phosphorylates and *activates* [mitogen activated protein kinase (MAPK)] in response to stimulation of various eukaryotic signaling pathways . Positive_regulation MAPK6 MAP2K6 7889302 289477 2. Both nucleotides stimulate phosphorylation and *activation* of [mitogen activated protein kinase] and a biphasic phosphorylation of the up-stream . Positive_regulation MAPK6 MAP2K6 8180183 256277 This stimulation of the activator was temporally *followed* by increased activities of MEK and [MAPK] . Positive_regulation MAPK6 MAP2K6 8226933 235448 *Activation* of extracellular signal regulated kinase ( ERK ) or [mitogen activated protein kinase] by ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAPK6 MAP2K6 8394352 228278 We show that a similar activity phosphorylates and *activates* [MAPK] in both growth factor stimulated ( epidermal growth factor and thrombin ) and oncogene ( gip2 , v-src , and v-raf ) -transfected cells . Positive_regulation MAPK6 MAP2K6 8550616 346710 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Positive_regulation MAPK6 MAP2K6 8663100 368195 The [MAPK] and NHE activities induced by PMA were *inhibited* by staurosporine , a potent inhibitor for protein kinase C ( PKC ) , and by MAPK kinase ( ) inhibitor , PD98059 , but were not affected by the tyrosine kinase inhibitor genistein . Positive_regulation MAPK6 MAP2K6 8663100 368295 In contrast , both AVP induced [MAPK] and NHE activities were *inhibited* by genistein and inhibitor but were not affected by staurosporine . Positive_regulation MAPK6 MAP2K6 8816498 384332 *activates* [mitogen activated protein kinase (MAPK)] , which phosphorylates other kinases as well as transcription factors . Positive_regulation MAPK6 MAP2K6 9135064 427649 In addition to dependent [MAPK] *activation* , we provide evidence for MEK independent regulation of the MAPKs . Positive_regulation MAPK6 MAP2K6 9166761 432497 The first step in [MAPK] *activation* by must be the formation of a MEK x MAPK enzyme-substrate complex , followed by phosphorylation producing monophosphorylated MAPK ( pMAPK ) . Positive_regulation MAPK6 MAP2K6 9626658 511937 These results indicate that *mediates* the IGF-I/insulin induced p42/ p44 [MAPK] activation . Positive_regulation MAPK6 MAP2K6 9864179 582766 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of ERK , but not p38 [MAPK] , induced by G-CSF , GM-CSF , or TNF . Positive_regulation MAPK6 MMP7 16848631 1588329 and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 [mitogen activated protein kinase] activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MAPK6 MMP7 21999204 2547389 Mesothelin enhances invasion of ovarian cancer by *inducing* through [MAPK/ERK] and JNK pathways . Positive_regulation MAPK6 MUC16 11481474 843924 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a [mitogen activated protein kinase] ( Erk 1/2 ) , and *activation* of transcription . Positive_regulation MAPK6 PECAM1 18029285 1866926 In contrast , expression of Delta15 in PECAM-1-/- bEND cells *had* minimal effects on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Positive_regulation MAPK6 PGC 22105890 2599546 Our studies also revealed that overexpression of in cardiomyocytes *inhibited* basal and T3-induced p38 [MAPK] phosphorylation . Positive_regulation MAPK6 PIGR 20450283 2257152 Induction of expression in HT-29 cells *required* NF-kappaB signaling but not [MAPK] signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation MAPK6 PLAT 19436314 2107043 cerebrospinal fluid and brain parenchymal ERK [MAPK] was elevated by H/I and this upregulation was *potentiated* by , but blunted by RBC-tPA . Positive_regulation MAPK6 PLAT 21037505 2499499 Red blood blocked c-Jun-N-terminal kinase but *potentiated* p38 [mitogen activated protein kinase] upregulation after photothrombotic injury . Positive_regulation MAPK6 PLAU 10766865 684609 surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha [mitogen activated protein kinase] activity . Positive_regulation MAPK6 PLAU 15031204 1257173 In HeLa cells the dominant negative form of JNK interferes with the p42/p44 [MAPK] *activation* of the . Positive_regulation MAPK6 PLAU 15874933 1405702 Activation of the [mitogen activated protein kinases (MAPK)] , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Positive_regulation MAPK6 PLAU 15874933 1405735 Although uPA induced phosphorylation of both ERK1/2 and p38 MAPK was blocked by Galphai inhibition , inhibition of PI3K and Ras decreased the *induced* phosphorylation of ERK1/2 but not p38 [MAPK] . Positive_regulation MAPK6 PLAU 18656457 1960568 Exogenous administered at 4 h post H/I further *stimulated* ERK [MAPK] phosphorylation , which was blocked by RAP . Positive_regulation MAPK6 PLAU 9660790 517503 The receptor *mediates* tyrosine phosphorylation of focal adhesion proteins and activation of [mitogen activated protein kinase] in cultured endothelial cells . Positive_regulation MAPK6 PLAU 9660790 517516 The induced *activation* of [MAPK] was completely inhibited by genistein , but not by 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo [ 3 , 4-d ] pyrimidine , a specific inhibitor of Src family kinases . Positive_regulation MAPK6 PODXL 17616675 1769277 expression also *led* to an increase in [mitogen activated protein kinase (MAPK)] and phosphatidylinositol 3-kinase (PI3K) activity . Positive_regulation MAPK6 PODXL 17616675 1769324 These findings suggest that leads to increased in vitro migration and invasion , increased MMP expression , and *increased* activation of [MAPK] and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MAPK6 PTGER2 19233324 2072063 Further , PGE ( 2 ) , EP2A and EP4A did not increase BMP2/4 mRNA levels in RC cells , and *induced* phosphorylation of p38 [MAPK] was not eliminated by Noggin . Positive_regulation MAPK6 SLC38A3 15331357 1288037 In contrast , *stimulated* [MAPK] activation was blocked by > 80 % by dominant negative Ras but not by dominant negative Rho and Cdc42 . Positive_regulation MAPK6 SNCAIP 12639553 1068707 In addition , [MAPK] was *activated* by through Edg-1 , Sph-1-P receptor . Positive_regulation MAPK6 SPHK1 18602364 1941512 As a result , inhibition of by SKI *blocked* phosphorylation of p38 [MAPK] , showing that SPHK activation by IL-18 is an upstream signal of p38 MAPK activation . Positive_regulation MAPK6 STK39 17237610 1690331 The phosphorylation of cytoplasmic p38 [MAPK] in Akata cells was *reduced* by the inhibitor , 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperazine ( H7 ) . Positive_regulation MAPK6 TLR7 16424221 1515605 MKP-1-deficient macrophages also show enhanced constitutive and *induced* activation of p38 [MAPK] . Positive_regulation MAPK6 TLR7 23979601 2850685 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Positive_regulation MAPK6 TLR7 24879442 2941036 GIT2 terminates *induced* NF-?B and [MAPK] signaling by recruiting the deubiquitinating enzyme Cylindromatosis to inhibit the ubiquitination of TRAF6 . Positive_regulation MAPK6 TNF 10504489 648986 Pretreatment with SB203580 ( 10 microM ) had no effect on basal or TNF-alpha stimulated phosphorylation of p38 MAPK but completely abolished *stimulated* p38 [MAPK] activity . Positive_regulation MAPK6 TNF 10521481 653116 The study presented here shows that autoregulation of gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 [mitogen activated protein (MAP) kinase] activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation MAPK6 TNF 10570180 568164 Furthermore , LPS , UV irradiation , and *caused* activation of p38 [MAPK] whereas IFN-gamma did not . Positive_regulation MAPK6 TNF 10601128 574215 alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation MAPK6 TNF 10640438 577511 IL-1 beta and also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK6 TNF 10669634 665811 In this study , we show that *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation MAPK6 TNF 10753884 682346 Moreover , *stimulated* both the NF-kappaB and [mitogen activated protein (MAP) kinase] ( extracellular signal regulated kinase , c-Jun NH ( 2 ) -terminal kinase , and p38 MAP kinase ) signaling pathways in astrocytes . Positive_regulation MAPK6 TNF 10783388 707853 *dependent* p38 [MAPK] activation was detected in both Mo7e and Hut-78 cells and was blocked by the p38 MAPK inhibitor , SB203580 . Positive_regulation MAPK6 TNF 10783388 707906 SB203580 did not affect TNF-alpha signaled nuclear translocation and DNA binding activity of NF-kappaB , and inhibition of NF-kappaB function did not affect *induced* p38 [MAPK] activation , indicating that these events are not dependent on each other . Positive_regulation MAPK6 TNF 10864897 705733 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK6 TNF 10864897 705785 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by and IL-1beta . Positive_regulation MAPK6 TNF 11095634 755303 rapidly *activated* [MAPK] and increased the extent of attachment , spreading and migration on fibronectin and collagen type I ( P < 0.01 ) but not on collagen type IV . Positive_regulation MAPK6 TNF 11108246 756732 *activates* extracellular regulated kinase-1/2 ( ERK1/2 ) and [p38MAPK] . Positive_regulation MAPK6 TNF 11108836 757043 In RAW264 cells which differentiate into osteoclast-like multinucleated cells by TNF treatment alone , activation of p38 [mitogen activated protein (MAP) kinase] *induced* by murine was comparable to and independent of the receptor activator of necrosis factor-kappaB ligand . Positive_regulation MAPK6 TNF 11156586 780619 1. We have previously shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce interleukin-8 (IL-8) by human pulmonary vascular endothelial cells . Positive_regulation MAPK6 TNF 11167962 783070 It has previously been shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce cytokine , including RANTES , that N-acetylcysteine (NAC) attenuates cytokine production by human bronchial epithelial cells ( BECs ) , and that sensitivity to TNFalpha is inversely correlated with cellular redox state . Positive_regulation MAPK6 TNF 11266661 797173 However , *caused* no activation of p42/p44 [MAPK] or cytosolic phospholipase A(2) activity . Positive_regulation MAPK6 TNF 11277995 798115 *activates* extracellular regulated kinases ( ERKs ) and p38 [mitogen activated protein kinase] ( p38MAPK ) , and inhibits the expression of uncoupling protein-1 (UCP-1) and adipocyte-specific genes in rat fetal brown adipocytes . Positive_regulation MAPK6 TNF 11319753 806843 SB 203580 , a selective inhibitor of p38 MAPK , inhibited IL-1 and *induced* p38 [MAPK] activity and IL-6 production ( IC ( 50 ) s 0.3 -- 0.5 microM ) in osteoblasts and chondrocytes . Positive_regulation MAPK6 TNF 11319753 806874 In addition , IL-1 and also *activated* p38 [MAPK] in fetal rat long bones and p38 MAPK inhibitors inhibited IL-1- and TNF stimulated bone resorption in vitro in a dose dependent manner ( IC ( 50 ) s 0.3 -- 1 microM ) . Positive_regulation MAPK6 TNF 11435466 832533 However , the cytotoxic responses to daunorubicin and exogenous ceramide remain unaltered , as do the induced p42/p44 [MAPK] *activation* and CD54 expression . Positive_regulation MAPK6 TNF 11438547 843398 *activated* p38 [MAPK] and p44/p42 MAPK in wild-type but not in p60 ( -/- ) , p80 ( -/- ) , or p60 ( -/- ) p80 ( -/- ) macrophages . Positive_regulation MAPK6 TNF 11494147 846177 In this study we demonstrate that *triggers* only modest proliferation , as well as p44/p42 [mitogen activated protein kinase (MAPK)] and NF-kappaB activation , in MM.1S multiple myeloma ( MM ) cells . Positive_regulation MAPK6 TNF 11495721 846400 Furthermore , overexpression of dominant negative mutants , H-Ras-15A and Raf-N4 , significantly suppressed p42/p44 [mitogen activated protein kinase (MAPK)] activation *induced* by and PDGF-BB and attenuated the effect of TNF-alpha on BK-induced IP response , indicating that Ras and Raf may be required for activation of these kinases . Positive_regulation MAPK6 TNF 11509550 848372 Although IL-1 beta and each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK6 TNF 11592111 869669 Lipopolysaccharide (LPS) treatment of a microglial cell line ( N9 ) *induced* a time dependent activation of both p38 [mitogen activated protein kinase] ( p38 MAPK ) and nuclear factor-kappaB (NFkappaB) , with consequent increases in interleukin-1alpha (IL-1alpha) , , and nitric oxide ( NO ) production . Positive_regulation MAPK6 TNF 11694522 896418 *activated* the three mammalian [MAPK] , p44/42 , JNK , and p38 , in a distinct time- and concentration dependent manner . Positive_regulation MAPK6 TNF 11694522 896444 In conclusion , although *activates* all three known [MAPK] in human preadipocytes , only p44/42 and JNK appear to be involved in the regulation of lipolysis . Positive_regulation MAPK6 TNF 11750919 898176 Biochemical and immunocytochemical analysis showed that *activated* p38 [mitogen activated protein kinase] ( p38MAPK ) and c-Jun N-terminal kinase (JNK) but not p42/p44 MAPK . Positive_regulation MAPK6 TNF 11820362 908743 *activated* p38 [MAPK] and stimulated IL-6 secretion by MG-63 cells , and pre-incubation of cells with the p38 MAPK inhibitor abrogated TNF-alpha dependent IL-6 secretion . Positive_regulation MAPK6 TNF 11820362 908772 Transfection of IL-6 full-length and 5-deletion gene promoter reporter constructs indicated that p38 [MAPK] *activation* by enhanced IL-6 gene expression , and that the p38 MAPK-responsive region resided in the proximal 260-bp segment . Positive_regulation MAPK6 TNF 11820362 908808 In conclusion , although p38 [MAPK] *activation* by stimulates IL-6 secretion by MG-63 cells , it has opposing effects on c/EBPbeta and NFkappaB activity . Positive_regulation MAPK6 TNF 11930247 927423 The p44/42 [MAPK] activity was significantly *enhanced* by and the TNF-alpha effect was opposed by rhIL-10 . Positive_regulation MAPK6 TNF 11930247 927436 It is suggested that rhIL-10 can inhibit *induced* VSMC proliferation and phosphorylation of p44/42 [MAPK] . Positive_regulation MAPK6 TNF 12095140 960569 significantly increased permeability and *induced* p38 and ERK [MAPK] activation compared with controls ( P < 0.05 ) . Positive_regulation MAPK6 TNF 12114204 963999 *increased* the phosphorylation of p38 MAPK within 15 min. Anisomycin , an activator of p38 MAPK , increased p38 [MAPK] phosphorylation and decreased SP-A mRNA levels in a dose dependent manner . Positive_regulation MAPK6 TNF 12130576 966588 Phosphorylation of p38 [MAPK] was *induced* by RANKL , IL-1 , , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation MAPK6 TNF 12131776 966866 IL-1 beta and *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK6 TNF 12297009 991042 In this study , we examined the anti-apoptotic role of p38 [MAPK] that is *activated* by in neuronal PC12 cells . Positive_regulation MAPK6 TNF 12297009 991055 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Positive_regulation MAPK6 TNF 12393915 1025443 This model probiotic also inhibits *activation* of the pro-apoptotic [p38/mitogen activated protein kinase] by , interleukin-1alpha , or gamma-interferon . Positive_regulation MAPK6 TNF 12511413 1079049 The treatment of RAW264 cells with TSA and NaB inhibited *induced* nuclear translocation of NF-kappa B and sRANKL induced activation of p38 [mitogen activated protein kinase (MAPK)] signals . Positive_regulation MAPK6 TNF 12631113 1067620 Additional experiments examining the role of cAMP on MC fractalkine expression showed that the incubation of MCs with TNF-alpha and either db-cAMP or forskolin attenuated TNF-alpha stimulated fractalkine mRNA and protein expression , preceded by attenuation of *activated* phosphorylation of p42/44 [MAPK] , and c-Jun , but not phosphorylation of PKCzeta/iota or nuclear translocation of NF-kappaB . Positive_regulation MAPK6 TNF 12637577 1099320 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and *requires* p38 [MAPK] activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation MAPK6 TNF 12665666 1030375 This study was undertaken to examine the relationship between *induced* cardiomyocyte apoptosis and activation of p38 [mitogen activated protein kinase (MAPK)] through oxidative stress . Positive_regulation MAPK6 TNF 12665666 1030388 Corresponding to the apoptotic effect , at 10 ng/mL *caused* rapid phosphorylation of p38 [MAPK] in wild-type cardiomyocytes . Positive_regulation MAPK6 TNF 12694807 1080914 *induced* the phosphorylation of p44/p42 [mitogen activated protein (MAP) kinase] and p38 MAP kinase . Positive_regulation MAPK6 TNF 12731668 1086850 On the other hand , GM-CSF- or *induced* phosphorylation of ERK and p38 [MAPK] was unaffected by these inhibitors at the concentrations effective for the inhibition of O2- release and adherence . Positive_regulation MAPK6 TNF 12829618 1113809 However , *induced* [p38-MAPK] phosphorylation was markedly diminished in mkk3-/- vs mkk3+/+ hearts ( percent basal , 127+/-23 versus 540+/-267 , respectively , P=0.04 ) , suggesting an MKK independent activation mechanism by ischemia . Positive_regulation MAPK6 TNF 12844496 1149733 Rho inhibition decreases *induced* endothelial [MAPK] activation and monolayer permeability . Positive_regulation MAPK6 TNF 12844496 1149746 Because GTP binding proteins have been implicated in MAPK activation , we now hypothesize that the GTP binding protein Rho is a mediator of induced [MAPK] *activation* and increased endothelial permeability . Positive_regulation MAPK6 TNF 12844496 1149760 C3 transferase attenuated induced [MAPK] *activation* and blocked TNF induced endothelial permeability . Positive_regulation MAPK6 TNF 12867430 1142016 Subsequently , mediated p38 [MAPK] *activation* induced sialidase activity and CD44-HA binding . Positive_regulation MAPK6 TNF 12867430 1142110 Taken together , our results suggest that induced p38 [MAPK] *activation* may regulate the induction of functionally active HA-binding form of CD44 by activating sialidase in LPS stimulated human monocytic cells . Positive_regulation MAPK6 TNF 12881424 1116135 Importantly , does not *induce* ROS accumulation or prolonged [MAPK] activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death Positive_regulation MAPK6 TNF 12893778 1121033 We show that MKK3 and MKK6are essential for *stimulated* p38 [MAPK] activation . Positive_regulation MAPK6 TNF 12960255 1158291 To investigate a potential interplay between *induced* activation of p38 [MAPK] and NF-kappaB , the p38 MAPK inhibitor SB203580 and a dominant negative p38 MAPK mutant were used . Positive_regulation MAPK6 TNF 14516792 1147207 [MAPK] pathway *activation* via was confirmed by marked AP-1 activation detected in EMSA . Positive_regulation MAPK6 TNF 14561851 1165109 In cultured human umbilical vein endothelial cells ( HUVECs ) , and lipopolysaccharide *increased* phosphorylation of p38 [MAPK] ( P-p38 MAPK ) and increased ICAM-1 expression . Positive_regulation MAPK6 TNF 14592823 1209468 Analyzing the individual contribution of PF-4 and its costimuli in the control of these functions at the signaling level , we demonstrate that induced *activation* of p38 [mitogen activated protein (MAP) kinase] ( but not extracellular regulated kinase [ Erk ] kinases ) acts as general and essential costimulatory signal in PF-4 dependent neutrophil exocytosis . Positive_regulation MAPK6 TNF 14632659 1170654 *activated* p38 [MAPK] in DCs only at an early time-point ( 15 min ) . Positive_regulation MAPK6 TNF 14654378 1176832 These findings suggest that the pre-ischemic *activation* of [p38-MAPK] by does not contribute to cardioprotection afforded by this agent . Positive_regulation MAPK6 TNF 15002040 1265088 Consistent with the abrogation of osteoclastogenic effect of DcR3 by TNFR-Fc , DcR3 treatment can *induce* osteoclastogenic cytokine release through ERK and p38 [MAPK] signaling pathways . Positive_regulation MAPK6 TNF 15139014 1246961 The increase in release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not [mitogen activated protein kinase (MAPK)] , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation MAPK6 TNF 15191888 1295243 Treatment of endothelial cells with SphK1 siRNA suppressed *induced* increase in MCP-1 mRNA levels , MCP-1 protein secretion , and activation of p38 [MAPK] . Positive_regulation MAPK6 TNF 15212763 1262324 Interestingly , Ad5NIK , but not , *induces* RelA S536 and p38 [mitogen activated protein kinase (MAPK)] phosphorylation in IKKgamma ( -/- ) cells . Positive_regulation MAPK6 TNF 15233873 1269394 A. semen also inhibited the expression of and the *activation* of [mitogen activated protein kinase] , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation MAPK6 TNF 15240695 1270286 TNF activates Syk protein tyrosine kinase leading to *induced* [MAPK] activation , NF-kappaB activation , and apoptosis . Positive_regulation MAPK6 TNF 15240695 1270306 TNF induced Syk activation was abolished by piceatannol ( Syk-selective inhibitor ) , which led to the suppression of induced *activation* of c- JNK , p38 [MAPK] , and p44/p42 MAPK . Positive_regulation MAPK6 TNF 15240695 1270322 Jurkat cells that did not express Syk ( JCaM1 , JCaM1/lck ) showed lack of *induced* Syk , JNK , p38 [MAPK] , and p44/p42 MAPK activation , as well as TNF induced IkappaBalpha phosphorylation , IkappaBalpha degradation , and NF-kappaB activation . Positive_regulation MAPK6 TNF 15240695 1270353 Overall , our results demonstrate that Syk activation plays an essential role in induced *activation* of JNK , p38 MAPK , p44/p42 [MAPK] , NF-kappaB , and apoptosis . Positive_regulation MAPK6 TNF 15240725 1270461 p38 [MAPK] was *activated* by and oxidants in nonadherent conditions i.e. , with 10 mM EDTA . Positive_regulation MAPK6 TNF 15240725 1270475 Finally , p38 [MAPK] *activation* by was blocked by diphenylene iodonium , an inhibitor of flavoprotein oxidoreductase , and by the free radical scavenger N-acetylcystein . Positive_regulation MAPK6 TNF 15265936 1275737 Besides NF-kappa B , celecoxib also suppressed *induced* JNK , p38 [MAPK] , and ERK activation . Positive_regulation MAPK6 TNF 15290420 1278554 Halothane or isoflurane augmented the LPS- and *induced* activation of p38 [MAPK] . Positive_regulation MAPK6 TNF 15304089 1284483 DNCB , NiSO ( 4 ) and *activated* p38 [mitogen activated protein kinases (MAPK)] and c-jun N-terminal kinase ( JNK ) . Positive_regulation MAPK6 TNF 15322069 1333425 We have also investigated the phosphorylation of p42/44 [MAPK] and *upregulation* of RhoA protein by . Positive_regulation MAPK6 TNF 15452110 1341996 In contrast , induced p42/p44 [MAPK] *activation* and CD54 expression remained unaltered . Positive_regulation MAPK6 TNF 15589482 1356216 In addition , luteolin inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , IkappaB degradation , and NF-kappaB activation . Positive_regulation MAPK6 TNF 15659876 1350314 The anabolic effect of was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an extracellular regulated kinases (ERK) . Positive_regulation MAPK6 TNF 15696169 1372168 Using TCPTP-deficient fibroblasts , we show here that TCPTP regulates *induced* [MAPK] but not NF-kappaB signaling . Positive_regulation MAPK6 TNF 15696169 1372205 These results link TCPTP and Src tyrosine kinases to the selective regulation of *induced* [MAPK] signaling and identify a previously unknown mechanism for modulating inflammatory responses mediated by TNF . Positive_regulation MAPK6 TNF 15703956 1497472 *Activation* of p38 [mitogen activated protein (MAP) kinase] and phosphatidylinositol 3-kinase (PI3K) by was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation MAPK6 TNF 15792609 1386798 By stimulation of in AM-1 cells , the phosphorylation of Akt ( Ser473 ) and p44/42 [mitogen activated protein kinase (MAPK)] ( Thr202/Tyr204 ) was markedly *increased* in TNFalpha concentration and time dependent manner . Positive_regulation MAPK6 TNF 15792609 1386811 Pretreatment with U0126 , mitogen activated extracellular regulated kinase ( MEK) 1/2 inhibitor , prior to TNFalpha stimulation , specifically inhibited *induced* phosphorylation of p44/42 [MAPK] ( Thr202/Tyr204 ) in AM-1 cells . Positive_regulation MAPK6 TNF 15792609 1386827 Meanwhile , pretreatment with LY294002 , phosphatidylinositol-3-OH kinase (PI3K) inhibitor , could inhibit both *induced* phosphorylation of Akt ( Ser473 ) and p44/42 [MAPK] ( Thr202/Tyr204 ) . Positive_regulation MAPK6 TNF 15823554 1393916 Furthermore , potently *activated* p38 [MAPK] , JNK , and NF-kappaB . Positive_regulation MAPK6 TNF 15837794 1432553 Expression of this protein inhibited induced *activation* of NFkappaB , JNK , and p38 [MAPK] and sensitized the cells to TNF induced apoptosis . Positive_regulation MAPK6 TNF 15845648 1425551 *induces* a more than tenfold increase in p38 [mitogen activated protein kinase (MAPK)] but not extracellular signal regulated kinase phosphorylation . Positive_regulation MAPK6 TNF 15870903 1405551 In addition , GA inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , I kappa B alpha degradation , and NF-kappa B activation . Positive_regulation MAPK6 TNF 16009485 1441411 Moreover , p44/42 [mitogen activated protein kinase] appears to partly *mediate* the negative effect of insulin but not on ATGL . Positive_regulation MAPK6 TNF 16023081 1441592 Ellagic acid inhibited IL-1beta- and induced *activation* of activator protein-1 and mitogen activated protein kinases ( extracellular signal regulated kinase , c-Jun N-terminal kinase and p38 [mitogen activated protein kinase] ) , but not of nuclear factor-kappaB . Positive_regulation MAPK6 TNF 16025396 1435615 *activated* the phosphorylation of p44/42 [MAPK] , p38 MAPK , SAPK/JNK and Akt in mesangial cells . Positive_regulation MAPK6 TNF 16025396 1435631 PGE1 inhibited the *induced* phosphorylation of SAPK/JNK and Akt , but not p44/42 MAPK and p38 [MAPK] . Positive_regulation MAPK6 TNF 16080915 1442771 Comparative gene array analysis of *induced* [MAPK] and NF-kappaB signaling pathways between retinal ganglion cells and glial cells . Positive_regulation MAPK6 TNF 16140562 1499257 These results suggested that TNFalpha induced both cell survival and apoptosis pathways in ameloblastoma and potential of TNFalpha in inducing apoptosis can be improved by inhibiting *induced* Akt and p44/42 [mitogen activated protein kinase (MAPK)] cell survival pathways . Positive_regulation MAPK6 TNF 16275991 1480308 Angiotensin II , , or epidermal growth factor *induced* [MAPK] phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation MAPK6 TNF 16291729 1526074 *Activation* of [MAPK] and Akt by anti-HER2/neu inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation MAPK6 TNF 16314440 1487003 treatment *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation in NPCs , and SB202190 , an inhibitor of p38 MAPK , blocked TNF-alpha induced chemokine production . Positive_regulation MAPK6 TNF 16325162 1511668 Furthermore , APE1/ref-1 overexpression inhibited the *induced* increase in intracellular superoxide and p38 [MAPK] phosphorylation . Positive_regulation MAPK6 TNF 16452991 1611744 Western blots showed that IL-1beta and *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK6 TNF 16517732 1530944 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of , but not IL-6 , *requires* the activity of p38 [MAPK] . Positive_regulation MAPK6 TNF 16573652 1556140 HA-mediated production *required* p38 [MAPK] , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation MAPK6 TNF 16682409 1584061 Further , the deletion of NQO1 abolished induced c-Jun N-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] *activation* . Positive_regulation MAPK6 TNF 16781693 1585619 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and and the *activation* of [MAPK] 's are potentially positive signals for IL-10 production . Positive_regulation MAPK6 TNF 16798728 1638538 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Positive_regulation MAPK6 TNF 16875982 1593566 *activates* [p38-MAPK] , a stress-responsive kinase implicated in contractile depression and cardiac injury . Positive_regulation MAPK6 TNF 16875982 1593580 Under conditions of constant coronary flow , the [p38-MAPK] activation and contractile depression *induced* by , though attenuated , remained sensitive to the absence of MKK3 or the presence of SB203580 . Positive_regulation MAPK6 TNF 16875982 1593594 *activates* [p38-MAPK] in the intact heart and in isolated cardiac myocytes through MKK3 . Positive_regulation MAPK6 TNF 16982923 1617366 Compared with wild-type cells , MIF-deficient cells were hyporesponsive to IL-1- and *induced* [MAPK] activity , AP-1 activity , and cellular proliferation , while NF-kappaB function was preserved . Positive_regulation MAPK6 TNF 17070777 1649840 Inhibition of Syk down-regulated *induced* p38 and p44/42 [MAPK] phosphorylation and nuclear translocation of p65 NF-kappaB . Positive_regulation MAPK6 TNF 17099067 1676204 Importantly , Dex is able to increase the expression of MKP-1 , which causes an inactivation of *induced* p38 [MAPK] and mediates inhibition of E-selectin expression . Positive_regulation MAPK6 TNF 17126899 1677677 Stimulation of ECs with *induced* rapid increases in the phosphorylation of their mitogen activated protein kinases ( MAPKs ) [ extracellular signal regulated kinase ( ERK ) , c-Jun-NH2-terminal kinase (JNK) , and p38 [MAPK] ] ; Positive_regulation MAPK6 TNF 17126905 1686555 Differential regulation of and GM-CSF *induced* activation of P38 [MAPK] in neutrophils and eosinophils . Positive_regulation MAPK6 TNF 17138860 1653550 The role of delta-PKC in *mediated* activation of [MAPK] is not known . Positive_regulation MAPK6 TNF 17138860 1653576 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 MAPK are involved in TNF antiapoptotic signaling and whether delta-PKC is a key regulator of [MAPK] *activation* by . Positive_regulation MAPK6 TNF 17138860 1653602 In human neutrophils , *activated* both p38 [MAPK] and ERK1/2 principally via TNFR-1 . Positive_regulation MAPK6 TNF 17158449 1694266 A green fluorescent protein fusion protein containing the last 100 residues of TAK1 ( TAK1-C100 ) abolished the interaction of endogenous TAB2/TAB3 with TAK1 , the phosphorylation of TAK1 , and prevented the activation of IKK and [MAPK] *induced* by IL-1 , , and RANKL . Positive_regulation MAPK6 TNF 17161959 1694542 Upon examination of the signaling components , we found that was a potent *activator* of p38 , p44/42 , p54/46 [MAPK] , and IkappaBalpha ( IkappaBalpha ) . Positive_regulation MAPK6 TNF 17172975 1679390 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the [MAPK] , and production of . Positive_regulation MAPK6 TNF 17172975 1679416 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the [MAPK] , and production of . Positive_regulation MAPK6 TNF 17189827 1680173 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Positive_regulation MAPK6 TNF 17202326 1680818 Augmented lipopolysaccharide induced production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK6 TNF 17202326 1680844 In this study , we show that augmented LPS induced production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK6 TNF 17218473 1732523 The RhoA inhibitor C3 exoenzyme and the ROCK inhibitor Y-27632 both attenuated induced [MAPK] *activation* and blocked AR expression in HIMEC . Positive_regulation MAPK6 TNF 17220297 1703057 TRAF2 and ASK1 play essential roles in *induced* [mitogen activated protein kinase] signaling . Positive_regulation MAPK6 TNF 17258890 1725460 The effects of and FasL on GrB expression were specifically *mediated* by [p38MAPK] ( Mitogen-activated-protein-kinase ) activation . Positive_regulation MAPK6 TNF 17425653 1748787 The percentage increases in IL-18 induced phosphorylation of extracellular signal regulated kinase ( ERK ) in Th cells of NDN and DN were significantly higher than controls ( P < 0.05 ) , while the percentage increase in *induced* phosphorylation of p38 [MAPK] in monocytes and IL-18 induced phosphorylation of p38 MAPK in Th cells and monocytes were significantly higher in NDN patients than controls . Positive_regulation MAPK6 TNF 17438131 1742781 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation MAPK6 TNF 17438336 1749079 FAK promoted *stimulated* [MAPK] activation needed for maximal IL-6 production . Positive_regulation MAPK6 TNF 17438336 1749103 Analysis of FAK ( -/- ) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity , Tyr-397 phosphorylation , and the Pro-712/713 proline-rich region of FAK were required for *stimulated* [MAPK] activation and IL-6 production . Positive_regulation MAPK6 TNF 17446186 1749514 *increased* p38 [MAPK] phosphorylation , potently stimulated IRS-1 serine phosphorylation , and blunted insulin stimulated IRS-1 tyrosine and Akt phosphorylation and eNOS activity . Positive_regulation MAPK6 TNF 17531219 1762174 On the other hand , aloe emodin did not affect *induced* activation of p38 [mitogen activated protein kinase] or generation of reactive oxygen species . Positive_regulation MAPK6 TNF 17607712 1798193 Although *induced* the activation of p38 [MAPK] , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation MAPK6 TNF 17725582 1801638 MAC inhibited *induced* p38 [mitogen activated protein kinase] activation and cell death in cultured Schwann cells . Positive_regulation MAPK6 TNF 17895408 1823969 IA did not interfere with induced *activation* of c-Jun N-terminal kinase (JNK) and p38 [mitogen activated protein kinase] . Positive_regulation MAPK6 TNF 17942934 1814218 Deletion of NQO2 also abolished induced c-Jun NH2-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] *activation* . Positive_regulation MAPK6 TNF 17994109 1851166 triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 [MAPK] , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation MAPK6 TNF 18039275 1828532 Further downstream in this axis of signalling , blockade *reduces* only acute bronchoconstriction , while [MAPK] inhibition abrogates completely endotoxin induced inflammation . Positive_regulation MAPK6 TNF 18060043 1853606 In cultures of Schwann cells , astrocytes , and microglia , sLRP-alpha inhibited *induced* activation of p38 [MAPK] and ERK/MAPK . Positive_regulation MAPK6 TNF 18061162 1861520 We demonstrate that *induced* proliferation of C4HD murine mammary tumor cells and of T47D cells through the activation of p42/p44 [MAPK] , JNK , PI3-K/Akt pathways and nuclear factor-kappa B (NF-kappa B) transcriptional activation . Positive_regulation MAPK6 TNF 18091748 1847371 *induced* phosphorylation of extracellular signal regulated kinase ( ERK ) and Akt , but not p38 [mitogen activated protein kinase (MAPK)] , was attenuated by nicardipine , cilnidipine , benidipine , efonidipine , and azelnidipine . Positive_regulation MAPK6 TNF 18227157 1884372 It was shown that these three proteins could ( i ) induce expression of and tissue factor and ( ii ) *induce* phosphorylation of p44/42 [mitogen activated protein kinases (MAPK)] and activation of early growth response factor 1 (Egr-1) . Positive_regulation MAPK6 TNF 18258304 1884800 However , over-expression of a dominant negative form of Rac strongly inhibited *induced* p42/44 [MAPK] kinase activation , but had little effect upon JNK and no effect upon p38 MAPK activity . Positive_regulation MAPK6 TNF 18287053 1872493 Here , we show that the murine CMV M45 protein binds to RIP1 and inhibits induced *activation* of NF-kappaB , p38 [MAPK] , and caspase independent cell death . Positive_regulation MAPK6 TNF 18287248 1896529 Flavopiridol suppresses induced *activation* of activator protein-1 , c-Jun N-terminal kinase , p38 mitogen activated protein kinase (MAPK) , p44/p42 [MAPK] , and Akt , inhibits expression of antiapoptotic gene products , and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells . Positive_regulation MAPK6 TNF 18314542 1931910 P < 0.05 ) , and MKP-1 up-regulation was temporally related to the inhibition of *induced* p38 [MAPK] phosphorylation . Positive_regulation MAPK6 TNF 18336852 1912244 *stimulated* phosphorylation of p42/p44 [MAPK] and JNK were attenuated by pretreatment with the inhibitors U0126 and SP600125 or transfection with dominant negative mutants of DeltaERK and DeltaJNK . Positive_regulation MAPK6 TNF 18364436 1912772 We , for the first time , demonstrate that binding of staphylococcal enterotoxin B to MHC-II results in activation of TNF-alpha converting enzyme , epidermal growth factor receptor , [p38MAPK] , and NF-kappaB *inducing* biphasic production . Positive_regulation MAPK6 TNF 18443205 1938530 Conversely , *induced* increases in insulin receptor substrate-1 serine phosphorylation ( Ser ( 312 ) ) , Jun NH ( 2 ) -terminal kinase phosphorylation , and extracellular signal related kinase-1/2 [mitogen activated protein kinase (MAPK)] phosphorylation were unaltered by siRNA mediated IKKbeta reduction . Positive_regulation MAPK6 TNF 18518937 1971924 Although Cot/Tpl2 was phosphorylated in IRI and in the cultured tubular epithelial cells (TEC) after stimulation with LPS and hydrogen peroxide , there were no significant differences in terms of production , neutrophil infiltration or [MAPK] *activation* between Cot/Tpl2 ( +/+ ) and Cot/Tpl2 ( -/- ) mice . Positive_regulation MAPK6 TNF 18636175 1937274 Furthermore , glucosamine inhibited the *induced* phosphorylation of [p38MAPK] and NF-kappaB p65 , and the nuclear translocation of NF-kappaB in the cells . Positive_regulation MAPK6 TNF 18653803 1960521 PMA stimulated nSMase2 translocation was independent of p38 MAPK , and neither PKC inhibitors nor small interfering RNA had significant effects on *stimulated* p38 [MAPK] activation , indicating that PKC-delta does not act through p38 MAPK in regulating nSMase2 . Positive_regulation MAPK6 TNF 18710428 2028205 As for the signalling pathway , stimulation *led* to the phosphorylation of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and translocation of nuclear factor kappaB (NF-kappaB) ( p65 ) into the nuclei . Positive_regulation MAPK6 TNF 18710428 2028231 These data suggest that interaction *leads* to the phosphorylation of Erk1/2 and [p38MAPK] and nuclear translocation of NF-kappaB , which is closely associated with the production and activation of MMP-9 in cultured CC cells of HuCTT-1 and CCKS-1 . Positive_regulation MAPK6 TNF 18768892 1957231 Consistently , Nod2-null macrophages tolerant to LPS and MDP showed enhanced production of and IL-6 as well as increased NF-kappaB and [MAPK] *activation* in response to the dipeptide KF1B , the Nod1 agonist . Positive_regulation MAPK6 TNF 18948845 2053244 Hypertonic saline did not alter *induced* p38 [mitogen activated protein kinase] phosphorylation or constitutive vascular endothelial growth factor expression , suggesting that the observed inhibition is not a generalized suppression of protein phosphorylation or cellular function . Positive_regulation MAPK6 TNF 19100731 2031225 at 30 ng/ml significantly *increased* phosphorylation of receptor tyrosine kinase ( 175 kDa ) and p42 [mitogen activated protein (MAP) kinase] . Positive_regulation MAPK6 TNF 19130554 2025304 Stimulation of HIMEC with *triggered* phosphorylation of the [MAPK] , and up-regulation of VCAM-1 , FKN and ICAM-1 . Positive_regulation MAPK6 TNF 19234337 2079514 Analysis of downstream signals showed that inhibition of NAD(P)H oxidase partially inhibited NF-kappaB activation but did not reduce CCL2 mRNA stability or prevent *induced* phosphorylation of [p38MAPK] . Positive_regulation MAPK6 TNF 19275968 2072848 *stimulated* the phosphorylation levels of p38 [MAPK] , JNK , ERK1/2 and Akt in vascular endothelial cells . Positive_regulation MAPK6 TNF 19289468 2073042 The requirement for MADD was highly specific for induced *activation* of [MAPK] but not the related JNK and p38 kinases . Positive_regulation MAPK6 TNF 19371952 2081766 Of note , the IFN-gamma plus *stimulated* activation of p38 [MAPK] was suppressed following incubation with forskolin or DBcAMP alone . Positive_regulation MAPK6 TNF 19410630 2089699 By transfection of TAK1 siRNA , *induced* phosphorylation of IkappaBalpha , JNK1/2 , and [p38MAPK] , as well as IL-6 or IL-8 expression , were repressed . Positive_regulation MAPK6 TNF 19427347 2106798 *induced* the phosphorylation of p38 [mitogen activated protein (MAP) kinase] , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation MAPK6 TNF 19429670 2106871 Ang II and clearly *enhanced* ERK and [p38MAPK] phosphorylation . Positive_regulation MAPK6 TNF 19563733 2122012 Finally , EZS inhibited *induced* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phosphorylation . Positive_regulation MAPK6 TNF 19648110 2138335 This correlates with reduced *stimulated* p38 [MAPK] phosphorylation . Positive_regulation MAPK6 TNF 19648110 2138350 Repression of *induced* p38 [MAPK] phosphorylation , NF-kappaB dependent transcription , and IL-8 expression by dexamethasone are sensitive to transcriptional or translational inhibitors . Positive_regulation MAPK6 TNF 19648110 2138421 Thus , MKP-1 attenuates dependent *activation* of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Positive_regulation MAPK6 TNF 19648110 2138448 Small interfering RNA knockdown of dexamethasone induced MKP-1 expression partially reverses the repression of *activated* p38 [MAPK] , demonstrating that MKP-1 participates in the dexamethasone dependent repression of this pathway . Positive_regulation MAPK6 TNF 19788916 2163926 ( TNF-alpha ) and H ( 2 ) O ( 2 ) *activate* [mitogen activated protein kinase (MAPK)] in SH-SY5Y cells within 5 min and this activation is completely blocked by DLPC ( 12 microM ) . Positive_regulation MAPK6 TNF 19877072 2160715 CpdA also displayed profound effects on induced [MAPK] *activation* . Positive_regulation MAPK6 TNF 19877072 2160732 In sharp contrast , DEX did not affect induced IKK phosphorylation , IkappaBalpha degradation , p65 nuclear translocation , or [MAPK] *activation* in RA FLS . Positive_regulation MAPK6 TNF 19889458 2197307 Calpain inhibition induces random migration in TNF-alpha stimulated cells and prevents the generation of reactive oxygen species , but does not alter *mediated* activation of p38 [MAPK] and ERK MAPK . Positive_regulation MAPK6 TNF 20231691 2237862 TNF-alpha treatment resulted in the phosphorylation of p38 MAPK and its downstream target , MAPK activated protein kinase-2 , but IFN-gamma did not affect the levels of [MAPK] and MAPK activated protein kinase-2 phosphorylation *induced* by . Positive_regulation MAPK6 TNF 20489729 2327424 induced *activation* of p38 [MAPK] and the production of inducible nitric oxide synthase were suppressed in ASK1-deficient Müller glial cells . Positive_regulation MAPK6 TNF 20646342 2292553 Effects of budesonide on P38 [MAPK] activation , apoptosis and IL-8 secretion , *induced* by and Haemophilus influenzae in human bronchial epithelial cells . Positive_regulation MAPK6 TNF 20646342 2292581 *induced* a significant increase in p38 [MAPK] phosphorylation . Positive_regulation MAPK6 TNF 20693316 2351482 In four of the six donors , basal and *induced* ERK and p38 [MAPK] activation were higher in ASMA than ASMNA cells . Positive_regulation MAPK6 TNF 20696856 2351513 Surprisingly , replenishment with exogenous GSH normalizes both *dependent* NF-?B as well as [MAPK] signaling and rescues hepatocytes from FKB induced death . Positive_regulation MAPK6 TNF 20951126 2364968 Taken together , this study provided first evidence demonstrating that TRAIL- , , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK6 TNF 21123734 2377726 The ability of CO to inhibit *induced* ERK1/2 and p38 [MAPK] activities in an Akt dependent manner appears to be the key element in ROS dependent survival of endothelial cells during TNF-a mediated brain inflammatory disease . Positive_regulation MAPK6 TNF 21181166 2499617 IL-1ß and *activated* the intracellular mitogen activated protein kinases ( MAPKs ) : p44/42 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) as well as nuclear factor-?B ( NF-?B ) in osteoblasts . Positive_regulation MAPK6 TNF 21285293 2425732 Inhibitors of NADPH oxidase and/or p47phox siRNA diminished ROS production and COX-2 expression as well as phosphorylation of p38 [mitogen activated protein kinase] ( p38MAPK ) and Akt *mediated* either by AS serum or by . Positive_regulation MAPK6 TNF 21336587 2457993 Effects of preconditioning with sevoflurane on induced permeability and *activation* of p38 [MAPK] in rat pulmonary microvascular endothelial cells . Positive_regulation MAPK6 TNF 21422246 2416772 Interestingly , all PHA-L ( high ) DCs displayed a strongly reduced responsiveness to *induced* [p38-MAPK] activation compared with PHA-L ( low ) DCs , indicating differences in PHA-L binding capacities between DCs with different inflammatory properties . Positive_regulation MAPK6 TNF 21422246 2416786 Moreover , hybrid-type , but not complex-type , N-glycans are required for *induced* [p38-MAPK] activation and subsequent phenotypic maturation of BMDCs ( MHC-II , CD86 , CCR7 upregulation ) . Positive_regulation MAPK6 TNF 21520062 2423125 Here , we report that *induced* cPLA(2) protein and mRNA expression , PGE ( 2 ) production , and phosphorylation of p42/p44 MAPK , p38 [MAPK] , and JNK1/2 , which were attenuated by pretreatment with a ROS scavenger [ N-acetyl-L-cysteine , ( NAC ) ] and the inhibitors of NADPH oxidase [ apocynin (APO) and diphenyleneiodonium chloride ( DPI ) ] , MEK1/2 ( U0126 ) , p38 MAPK ( SB202190 ) , and JNK1/2 ( SP600125 ) or transfection with siRNA of Nox2 , p47(phox) , MEK1 , p42 , p38 , or JNK2 . Positive_regulation MAPK6 TNF 21545687 2554384 significantly *induced* phosphorylation of p38 [MAPK] , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation MAPK6 TNF 21894146 2510882 Vehicle and untreated NTN exhibited heavy proteinuria and glomerular thrombosis at 24 h with P-selectin and fibrin immunostaining within capillaries , glomerular macrophage and T cell infiltration , *activation* of JNK and p38 [MAPK] signalling , and upregulation of glomerular mRNA levels of pro-inflammatory molecules ( , NOS2 , MMP-12 and CCL2 ) . Positive_regulation MAPK6 TNF 22002864 2526331 These results suggest that H ( 2 ) O ( 2 ) -induced secretion of *increases* apoptosis of cardiac myocytes through ROS dependent activation of p38 [MAPK] . Positive_regulation MAPK6 TNF 22227193 2544580 Casuarinin significantly inhibited induced *activation* of NF-?B , STAT1 , and p38 [MAPK] . Positive_regulation MAPK6 TNF 22230399 2519480 KMUP-1 inhibited *induced* iNOS and U46619 induced PDE-5A and phospho-p38 [MAPK] in normoxia , confirming its anti-proinflammatory action . Positive_regulation MAPK6 TNF 22250084 2551215 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Positive_regulation MAPK6 TNF 22343222 2617826 Using immunohistological techniques , we showed a higher epithelial expression of , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator [protein-1/mitogen activated protein kinase] signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation MAPK6 TNF 22525504 2522576 *up-regulated* the phosphorylation levels of p38 [MAPK] and increased the translocation of NF-kB p65 protein into the nucleus , also proved by immunofluorescence staining . Positive_regulation MAPK6 TNF 22526394 2595917 also *increased* the production of inducible nitric oxide synthase (iNOS) , nitric oxide ( NO ) , and intercellular adhesion molecule 1 ( ICAM-1 ) through activation of p38 [mitogen activated protein kinase (MAPK)] from HT-29 cells . Positive_regulation MAPK6 TNF 22773691 2659906 *induced* activation of p38 [MAPK] and NF-?B was attenuated by miR-140-3p mimic . Positive_regulation MAPK6 TNF 22819264 2646099 CORM-2 inhibited induced *activation* of p38 [MAPK] , ERK1/2 , JNK , and NF-?B signaling pathways in HUVECs . Positive_regulation MAPK6 TNF 22947346 2678665 *induced* phosphorylated p38 [mitogen activated protein kinase] levels were increased in ASMCs from patients with severe asthma compared with those from patients with nonsevere asthma and nonasthmatic subjects , whereas TNF-a induced phosphorylated c-Jun N-terminal kinase and phosphorylated extracellular signal related kinase levels were increased in all asthmatic groups . Positive_regulation MAPK6 TNF 22988345 2674359 The EGF receptor and HER2 participate in dependent [MAPK] *activation* and IL-8 secretion in intestinal epithelial cells . Positive_regulation MAPK6 TNF 22988345 2674387 As the epidermal growth factor receptor (EGFR) is a known transducer of proliferative signals and a potent activator of MAPKs , we hypothesized that the EGFR participates in dependent [MAPK] *activation* and IL-8 secretion by intestinal epithelial cells ( IECs ) . Positive_regulation MAPK6 TNF 23071098 2720913 Mixed-effects modeling analysis of our data was vital for ascertaining that IL-1a and TGF-a treatment increased the activities of more pathways than IL-6 and TNF-a and that TGF-a and *increased* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phospho-protein levels in a synergistic manner . Positive_regulation MAPK6 TNF 23142559 2722790 Western blot analysis revealed that pilocarpine and physostigmine enhanced the *induced* phosphorylation of ERK1/2 and p38 [MAPK] and the degradation of I?Ba . Positive_regulation MAPK6 TNF 23333920 2758388 Interestingly , IL-27 promoted the basal and enhanced *induced* phosphorylation of p38 [MAPK] and Akt , but not I?Ba . Positive_regulation MAPK6 TNF 23353699 2754244 We further demonstrated that markedly *stimulated* p38 [MAPK] , p42/p44 MAPK , and JNK1/2 phosphorylation via a c-Src/EGFR , PDGFR/PI3K/Akt pathway . Positive_regulation MAPK6 TNF 23354775 2770555 p38a [mitogen activated protein kinases (MAPK)] may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , , interleukin-1ß , and oxidative stress . Positive_regulation MAPK6 TNF 23664593 2838387 sFGL2 secretion by CD4 ( + ) T cells can be *induced* with and IFN-? stimulation through [MAPK] signaling in renal allograft AR . Positive_regulation MAPK6 TNF 23861542 2817251 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Positive_regulation MAPK6 TNF 23884101 2821472 Furthermore , P. vulgaris extract suppressed *induced* phosphorylation of p38 [mitogen activated protein kinase (MAPK)] and extracellular signal regulated kinase ( ERK ) . Positive_regulation MAPK6 TNF 23935096 2840773 In contrast , loss of SK1 prevented *induced* phosphorylation of p38 [MAPK] , and inhibition of p38 MAPK , like SK1 knockdown , also potentiates RANTES induction . Positive_regulation MAPK6 TNF 24069158 2846997 We showed that markedly *stimulated* p42/p44 MAPK , p38 [MAPK] , and JNK1/2 phosphorylation which were attenuated by their respective inhibitors . Positive_regulation MAPK6 TNF 24080497 2902543 Consistently , DUSP1 promotes apoptosis and decreases NF-?B activity in cells in which p38 [MAPK] is *induced* by treatment . Positive_regulation MAPK6 TNF 24089494 2848154 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed receptor 1 and *requires* activation of p38 [MAPK] , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation MAPK6 TNF 24361597 2911249 We further demonstrated that *stimulated* ERK1/2 , p38 [MAPK] , and JNK1/2 phosphorylation via a c-Src dependent PDGFR/PI3K/Akt pathway . Positive_regulation MAPK6 TNF 24378531 2911777 TRAF2 has been previously reported to be required for *induced* activation of p38 [MAPK] . Positive_regulation MAPK6 TNF 24441870 2922937 We showed that markedly *stimulated* Jak2 , PDGFR , Akt , and p42/p44 [MAPK] phosphorylation , which were attenuated by their respective inhibitors . Positive_regulation MAPK6 TNF 24441870 2922955 In addition , *induced* p42/p44 [MAPK] phosphorylation was reduced by AG1296 or LY294002 . Positive_regulation MAPK6 TNF 24441870 2922991 On the other hand , could *induce* Akt and p42/p44 [MAPK] translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation MAPK6 TNF 24446489 2912942 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Positive_regulation MAPK6 TNF 24489443 2884796 Finally , by investigating the intracellular pathways involved in promoting the VEC release of cytokines/chemokines , which are targeted by natural anti-inflammatory compounds , we documented that aLipoic acid significantly counteracted *induced* NF-?B and [p38/MAPK] activation while the effects of Ginkgo biloba appeared to be predominantly mediated by Akt . Positive_regulation MAPK6 TNF 24750790 2936581 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas and NO production *required* all three [MAPK] . Positive_regulation MAPK6 TNF 7689564 225768 *induced* activation and increased tyrosine phosphorylation of [mitogen activated protein (MAP) kinase] in human fibroblasts . Positive_regulation MAPK6 TNF 7689564 225781 *induced* activation of [MAPK] was demonstrated by its enhanced ability to phosphorylate myelin basic protein in vitro and by a characteristic shift in the electrophoretic mobility of MAPK proteins . Positive_regulation MAPK6 TNF 7722327 301761 *induces* tyrosine phosphorylation of [mitogen activated protein kinase] in adherent human neutrophils . Positive_regulation MAPK6 TNF 7722327 301787 PMN pretreatment with genistein , a tyrosine kinase inhibitor , inhibited the *induced* increase in tyrosine phosphorylation and [MAPK] activity . Positive_regulation MAPK6 TNF 8626494 360280 Inhibition of *induced* p42/p44 [mitogen activated protein kinase] activation by sodium salicylate . Positive_regulation MAPK6 TNF 8626494 360294 *activates* both p42 and p44 [mitogen activated protein kinases (MAPK)] in human FS-4 fibroblasts , cells for which TNF is mitogenic . Positive_regulation MAPK6 TNF 8626494 360307 We now show that *activates* p42 [MAPK] in two cell lines whose growth is inhibited by TNF . Positive_regulation MAPK6 TNF 8626494 360322 We now show that neither phorbol ester-sensitive protein kinase C nor Gialpha link TNF to p42/p44 MAPK activation , because pretreatment of FS-4 cells with phorbol ester to down-regulate protein kinase C or pretreatment with pertussis toxin to block Gialpha does not inhibit p42/p44 [MAPK] *activation* by . Positive_regulation MAPK6 TNF 8626494 360348 To further analyze MAPK activation in FS-4 cells , we compared p42/p44 [MAPK] *activation* by and epidermal growth factor (EGF) . Positive_regulation MAPK6 TNF 8626494 360367 Elucidation of the mechanism whereby sodium salicylate blocks induced p42/p44 [MAPK] *activation* may help to clarify TNF activated signaling pathways . Positive_regulation MAPK6 TNF 8662702 367186 additionally *caused* rapid p38 and JNK-1 [mitogen activated protein kinase] activation and efficient NF-kappaB translocation , which could not be achieved even by high levels of ceramide . Positive_regulation MAPK6 TNF 9106254 424421 The increases in [MAPK] *induced* by and IL-1 were similar to the increases induced by PMA and PDGF-AB . Positive_regulation MAPK6 TNF 9106254 424447 Our findings indicate that and IL-1 activate parallel signal transduction pathways in human neuroma fibroblasts , and that they are relatively stronger *activators* of [MAPK] than of SAPK . Positive_regulation MAPK6 TNF 9315666 456104 , an inhibitor of insulin stimulated adipogenesis , *activated* [MAPK] in 3T3-L1 cells . Positive_regulation MAPK6 TNF 9439626 482873 *increased* ERK1 and ERK2 [MAPK] phosphorylation . Positive_regulation MAPK6 TNF 9439626 482899 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic effect of *requires* protein tyrosine phosphorylation and [MAPK] activation . Positive_regulation MAPK6 TNF 9593119 505489 The CAZ released endotoxin was similar to purified LPS with respect to the following biological activities in LPS-responsive C3H/HeN mice and LPS-hyporesponsive C3H/HeJ mice : lethal toxicity in GalN sensitized mice , in vitro induction of and NO production by macrophages , and [mitogen activated protein kinase] *activation* in macrophages . Positive_regulation MAPK6 TNF 9766635 538516 Our data suggest that and GM-CSF *activate* ERKs and p38 [MAPK] by different signal transduction pathways . Positive_regulation MAPK6 TNF 9770326 538806 Furthermore , *induction* of p42/p44 ERK and [p38-MAPK] phosphorylation , c-jun kinase activation , and IkappaBalpha degradation were normal . Positive_regulation MAPK6 TNF 9883899 558212 *Activation* of p42/p44 [mitogen activated protein kinases (MAPK)] and p38 MAPK by is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation MAPK6 TNF 9883899 558227 Here , we demonstrate that is *sufficient* to activate p42/p44 [MAPK] and p38 MAPK . Positive_regulation MAPK6 TNF 9930718 588841 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Positive_regulation MAPK6 TNF 9931102 588908 ( 100 U/mL ) transiently *activated* [MAPK] with a maximal induction 10 minutes after stimulation that returned to baseline levels by 2 hours after treatment . Positive_regulation MAPK6 TNF 9931102 588921 PD98059 also blocked *stimulated* [MAPK] activation in a concentration dependent manner , which is consistent with its inhibition of TNF-alpha directed migration . Positive_regulation MAPK6 TNF 9931102 588934 To identify which TNF-alpha receptor is involved in *induced* [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Positive_regulation MAPK6 TNF 9931102 588960 VSMC express both receptors , but *induced* [MAPK] activation was inhibited only by the TNF-R1 antibody . Positive_regulation MAPK6 TNF 9931102 588986 Both TRO and RSG inhibited migration , but neither attenuated induced [MAPK] *activation* , indicating that their antimigration activity was exerted downstream of MAPK . Positive_regulation MAPK6 TNFSF10 12969966 1185575 Among the intracellular pathways investigated , significantly *stimulated* the extracellular signal regulated kinase 1/2 ( ERK1/2 ) but not the [p38/mitogen activated protein kinase (MAPK)] or the c-Jun NH2-terminal kinase (JNK) pathway . Positive_regulation MAPK6 TNFSF10 20951126 2364969 Taken together , this study provided first evidence demonstrating that , TNF-a- , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK6 TNFSF10 21152872 2373397 Taken together , we show herein that the upstream molecule of the *induced* [MAPK] activation is MEKK , as opposed to ASK1 , via the mediation of its signal through JNK/p38 in a caspase-8 dependent manner . Positive_regulation MAPK7 ADRB2 11018034 752794 induced p38 [MAPK] *activation* is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes . Positive_regulation MAPK7 ADRB2 12509508 1038750 beta-Arrestin 1 is required for internalization and [mitogen activated protein (MAP) kinase] *activation* by the . Positive_regulation MAPK7 ADRB2 19047375 2023488 Hematopoietic protein tyrosine phosphatase mediates *induced* regulation of p38 [mitogen activated protein kinase] in B lymphocytes . Positive_regulation MAPK7 ADRB2 9038193 415369 In the present work , we report that stimulation of the A2A-adenosine receptor and of the *activates* [mitogen activated protein kinase] ( MAP kinase ) in human endothelial cells based on the following criteria : adenosine analogues and beta-adrenergic agonists cause an ( i ) increase in tyrosine phosphorylation of the p42 isoform and to a lesser extent of the p44 isoform of MAP kinase and ( ii ) stimulate the phosphorylation of myelin basic protein by MAP kinase; (iii) this is accompanied by a redistribution of the enzyme to the perinuclear region . Positive_regulation MAPK7 ADRB2 9363896 462912 We show that in HEK293 cells , *stimulation* of [mitogen activated protein (MAP) kinase] by the is mediated by the betagamma subunits of pertussis-toxin-sensitive G proteins through a pathway involving the non-receptor tyrosine kinase c-Src and the G protein Ras . Positive_regulation MAPK7 ALOX5 11807011 903512 In contrast , stress induced product formation and translocation of <5-LO> , as well as *activation* of p38 [MAPK] , occurred also after Ca ( ++ ) depletion . Positive_regulation MAPK7 ALOX5 21200133 2391696 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Positive_regulation MAPK7 ANGPT1 12039842 954285 Accordingly , ephrinB2 inhibited VEGF- and *induced* [Ras-MAPK] activities , whereas ephrinB2 did not alter VEGF induced Flk phosphorylation or Ang1 induced Tie2 phosphorylation . Positive_regulation MAPK7 ANGPT1 12213710 985651 Both VEGF and *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 [MAPK] . Positive_regulation MAPK7 ANGPT1 12213726 985721 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of and Ang-2 as well as the *activation* of [MAPK] , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation MAPK7 ANGPT1 16061664 1439073 *activated* [mitogen activated protein kinase (MAPK)] and phosphoinositide 3-kinase (PI3K) in IBE cells and HUVECs . Positive_regulation MAPK7 ANGPT1 16679392 1612157 Pretreatment with either DPI or apocynin also significantly attenuated *induced* Akt and p44/42 [MAPK] phosphorylation . Positive_regulation MAPK7 ANGPT1 16679392 1612173 Using mouse heart microvascular endothelial cells from wild-type ( WT ) mice and mice deficient in the p47(phox) component of NADPH oxidase ( p47 ( phox-/- ) ) , we found that although *stimulated* intracellular ROS , Akt and p42/44 [MAPK] phosphorylation , and cell migration in WT cells , the responses were strikingly suppressed in cells from the p47 ( phox-/- ) mice . Positive_regulation MAPK7 ANGPT1 17687003 1800438 We also found that MEKK3 is required for *induced* p38 and [ERK5] activation . Positive_regulation MAPK7 ANGPT1 20072135 2235291 *promoted* skin cell metabolism/viability , adhesion , and akt and [MAPK] ( p42/44 ) activations . Positive_regulation MAPK7 ANO1 22564524 2619166 *induces* [MAPK] and contributes directly to tumorigenesis and cancer progression . Positive_regulation MAPK7 CAPN8 21543591 2424173 Downstream , an Aß-mediated rise in p38 [mitogen activated protein kinase (MAPK)] activation was followed by downregulation of cAMP response element binding protein , and LTP impairment was *prevented* by inhibitors of p38 MAPK or . Positive_regulation MAPK7 CAPN8 24416390 2901041 Treatment with glutamate leads to early activation of NMDAR , which in turn leads to mediated cleavage of striatal enriched protein tyrosine phosphatase ( STEP ) and subsequent *activation* of p38 [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK7 CCL17 23711854 2792909 IL-33 induced the production of thymus and activation regulated and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 [MAPK] . Positive_regulation MAPK7 CCND1 11004713 735024 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping [ERK-MAPK] activation and c-Fos and *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation MAPK7 CCND1 12654183 1072988 [MAPK] may *induce* overexpression of protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation MAPK7 CCND1 15634644 1349558 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 [mitogen activated protein kinase] , and down-regulation of . Positive_regulation MAPK7 CCND1 16522728 1531462 We conclude that incretin induced beta-cell replication is dependent on cAMP/PKA , p42 [MAPK] and PI3K activities , which may *involve* transcriptional induction of . Positive_regulation MAPK7 CCND1 9537433 497568 Furthermore , in 25 of 26 cases of HCC which genomic DNA was available , 22 cases without genomic DNA amplification exhibited positive correlation , not only between protein expression of c-Fos and , but also between [MAPK/ERK] *activation* and cyclin D1 expression . Positive_regulation MAPK7 CD14 15625444 1349241 LPS interacts with the cell surface receptor , which generates transmembrane signals through Toll-like protein 4 *leading* to [mitogen activated protein kinase (MAPK)] p38 activation , cytokine synthesis , PMN beta2-integrin expression and oxidative burst . Positive_regulation MAPK7 CHI3L1 23755018 2797732 In addition , *induces* [FAK-MAPK] signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation MAPK7 CHI3L1 23972995 2836244 We also demonstrate that *activates* macrophage [mitogen activated protein kinase] , protein kinase B/AKT , and Wnt/ß-catenin signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation MAPK7 CLU 23051594 2702827 FOXL2 directly stimulates the Clu gene promoter , and we show that PTTG triggers ataxia telangiectasia mutated [kinase/IGF-I/p38MAPK] DNA damage/chromosomal instability signaling , which in turn also *induces* expression . Positive_regulation MAPK7 CTGF 11732999 885267 *induces* chondrocyte differentiation through a p38 [mitogen activated protein kinase] ( p38MAPK ) , and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase ( ERK ) . Positive_regulation MAPK7 CTGF 11732999 885281 In the proliferation phase , *induced* a approximately fivefold increase in the phosphorylation of p44/42 [MAPK/ERK] and a approximately twofold increase in that of p38 MAPK in an in vivo kinase assay . Positive_regulation MAPK7 CTGF 12218048 1012167 The inhibition of *induced* p42/44 [MAPK] or phosphatidylinositol 3-kinase (PI3K)/protein kinase B pathway activities abrogated the induction of fibronectin expression . Positive_regulation MAPK7 CTGF 16408113 1513482 *enhanced* the mRNA expression and protein release of fractalkine , MCP-1 , and RANTES , the expression of phospho ( P ) -p42/44 [mitogen activated protein kinase (MAPK)] , P-phosphoinositide 3-kinase (PI3-K) , P-Akt , and activity of nuclear factor-kappaB (NF-kappaB) in mesangial cells . Positive_regulation MAPK7 CTGF 16408113 1513520 P-p42/44 MAPK blockade inhibited the *induced* expression of P-p42/44 [MAPK] but not NF-kappaB , and partially decreased the levels of the above chemokines in supernatants . Positive_regulation MAPK7 CTGF 16522717 1531330 ( 3 ) *stimulated* dose dependent HSC adhesion and activity of p42/p44 [mitogen activated protein kinase] , the latter of which was antagonized by blocking the activity of focal adhesion kinase . Positive_regulation MAPK7 CTGF 16938382 1654129 No single module , but a mixture of the 4 modules provoked a significant activation of p38 [MAPK] in HCS-2/8 cells , which was *activated* by the full-length . Positive_regulation MAPK7 CTGF 19038999 2023093 Interestingly , CCN2-BMP-2 did not affect the *induced* phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Positive_regulation MAPK7 EDN2 12193071 980946 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Positive_regulation MAPK7 EDN2 12475899 1037784 *induced* a rapid phosphorylation of the [mitogen activated protein kinase (MAPK)/ERK] and increased collagen I gene activity in freshly isolated aortas . Positive_regulation MAPK7 EDN2 1280103 203051 rapidly *stimulates* [mitogen activated protein kinase] activity in rat mesangial cells . Positive_regulation MAPK7 EDN2 12855582 1149902 also *induced* the activation of p42/44 [mitogen activated protein kinase (MAPK)] in DCs . Positive_regulation MAPK7 EDN2 7509933 241618 *stimulates* [mitogen activated protein kinase] p42 activity through the phosphorylation of the kinase in rat mesangial cells . Positive_regulation MAPK7 EDN2 7849246 286742 *stimulates* [mitogen activated protein kinase] activity in mesangial cells through ETA . Positive_regulation MAPK7 EDN2 7943276 276409 has been shown to *activate* [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK7 EDN2 8836145 386183 In bovine airway smooth-muscle cells platelet derived growth factor ( PDGF ) and ( Et-1 ) *stimulate* sustained and comparable activation of [mitogen activated protein kinase] ( MAP kinase ) but display very different mitogenic efficacies , with PDGF inducing 50 times more DNA synthesis than Et-1 . Positive_regulation MAPK7 EFNB1 15502157 1347565 Further downstream of the signaling pathway , stimulation *led* to increased LAT ( linker for activation of T-cells ) phosphorylation and p44/42 and p38 [MAPK] activation . Positive_regulation MAPK7 EPHB2 10601128 574219 Tumor necrosis factor-alpha (TNF-alpha) alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only . Positive_regulation MAPK7 EPHB2 10872747 707030 Pre-treatment of the cells with PD98059 , a selective pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation MAPK7 EPHB2 11083274 750496 Tumor necrosis factor alpha , interleukin-1 (IL-1) , and IL-6 were the major inducers of , JNK , and p38 [MAPK] *activation* in cultured human synovial cells . Positive_regulation MAPK7 EPHB2 12386816 999768 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 [MAPK] and a biphasic *activation* of . Positive_regulation MAPK7 EPHB2 12403788 1036189 SB203580 , a p38 [MAPK] *inhibitor* , and PD98059 , an inhibitor , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation MAPK7 EPHB2 12486127 1056313 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain *had* little effect on basal Erk [MAPK] activation . Positive_regulation MAPK7 EPHB2 12511425 1070742 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation MAPK7 EPHB2 12801927 1120237 GE2 stimulation *induced* phosphorylation , whereas it did not alter the phosphorylation of c-Jun N-terminal kinase or p38 [MAPK] . Positive_regulation MAPK7 EPHB2 12832293 1105582 Exposure to E. coli DNA resulted in phosphorylation of ERK 1/2 [MAPK] and inhibitors of activity ( PD98059 , UO126 ) significantly *reduced* the evoked IL-8 production . Positive_regulation MAPK7 EPHB2 12878192 1115524 ( 2 ) the *activation* of JNK and p38 [MAPK] but not in embryonic fibroblasts ( MEFs ) derived from ASK1 knockout mice ( ASK1 ( -/- ) MEFs ) was depressed compared to MEFs derived from wild type mice ( ASK1 ( +/+ ) MEFs ) ; Positive_regulation MAPK7 EPHB2 14973553 1212747 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen activated protein kinase (MAPK)] signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation MAPK7 EPHB2 14998726 1216735 Furthermore , we found that PD98059 , an pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation MAPK7 EPHB2 15659876 1350317 The anabolic effect of TNF-alpha was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an . Positive_regulation MAPK7 EPHB2 16038626 1437435 SF significantly prevented Abeta induced increases in IL-1beta and p38 [MAPK] *activation* and also Abeta induced changes in and phospho-Akt/PKB expression levels . Positive_regulation MAPK7 EPHB2 17056059 1649532 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Positive_regulation MAPK7 EPHB2 17403539 1735939 Trauma-hemorrhage increased the production of IL-6 , IL-10 , IL-12 and TNF-alpha enhanced the expression of TLR4 , MyD88 as well as the *activation* of [MAPK] proteins ( p38 , and JNK ) in epidermal keratinocytes . Positive_regulation MAPK7 EPHB2 17416211 1777919 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK7 EPHB2 17464174 1731750 The mRNA and surface protein up-regulation of CCR1 and CCR2 in 9CRA stimulated cells were weakly blocked by the pretreatment of SB202190 , a p38 [MAPK] *inhibitor* , and PD98059 , an upstream inhibitor . Positive_regulation MAPK7 EPHB2 18164124 1869615 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 [MAPK] , but not by the *activation* of JNK , , and NF-kappaB pathway . Positive_regulation MAPK7 EPHB2 18266967 2000322 VEGF induced activation of p42 also *led* to the nuclear translocation of [MAPK/ERK1/2] . Positive_regulation MAPK7 EPHB2 18285354 1885411 Pre-treatment with the [MAPK] *inhibitors* SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( inhibitor ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation MAPK7 EPHB2 18338254 1938063 Interestingly , inhibition of by U0126 completely *prevented* artepillin C-induced p38 [MAPK] phosphorylation of PC12m3 cells . Positive_regulation MAPK7 EPHB2 18520049 1918678 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of , rather than by the *activation* of p38 [MAPK] , in the spinal cord . Positive_regulation MAPK7 EPHB2 18982426 2105752 These inhibitory effects were partially inhibited by SB203580 , a specific *inhibitor* of p38 [MAPK] , but not by PD98059 , a specific inhibitors of extracellular signal regulated kinase ( ) , and SP600125 , a specific inhibitor of c-Jun-N-terminal kinase (JNK) . Positive_regulation MAPK7 EPHB2 19189219 2113967 Moreover , EM1 treatment resulted in less activation of p38 [MAPK] and more *activation* of signaling in lipopolysaccharide stimulated DCs . Positive_regulation MAPK7 EPHB2 19276187 2051423 Treatment of cells with sphingosine induced suppression of and *activation* of p38 [MAPK] . Positive_regulation MAPK7 EPHB2 19429670 2106926 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either inhibitor , [p38MAPK] *inhibitor* or NF-kappaB inhibitor . Positive_regulation MAPK7 EPHB2 19522739 2103146 Treatment with [MAPK] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation MAPK7 EPHB2 19672126 2168077 A scratch wound assay of healing rates in SV40 immortalized human corneal epithelial cell line ( HCEC ) evaluated the relative contributions by p38 and and JNK [MAPK] signaling *activation* to wound healing . Positive_regulation MAPK7 EPHB2 20025124 2175518 Prior treatment of the cells with PD98059 , an kinase inhibitor or SB203580 , a [p38MAPK] *inhibitor* , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation MAPK7 EPHB2 20554538 2327627 The HNE enhanced Sp1 and NF-?B activities were attenuated by SB203580 , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , and PD98059 , an extracellular signal regulated kinase ( ) inhibitor , respectively . Positive_regulation MAPK7 EPHB2 21126656 2355804 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 [mitogen activated protein kinase] , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by . Positive_regulation MAPK7 EPHB2 21311676 2360039 Treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation MAPK7 EPHB2 21488184 2417978 Dexmedetomidine induced phosphorylation of JNK and p38 [MAPK] in rat aortic SMCs , but did not *induce* phosphorylation of . Positive_regulation MAPK7 EPHB2 21586573 2449671 Incubation of T cells with ESAT-6 induced phosphorylation and increased functional p38 [MAPK] activity , but not *activation* of or JNK . Positive_regulation MAPK7 EPHB2 21599960 2445736 In the present studies , induction of central sensitization as indicated by spinal dorsal horn [MAPK] *activation* , specifically and p38 phosphorylation , was assessed in the MIA-OA model . Positive_regulation MAPK7 EPHB2 23394443 2713246 When compared to hamsters bearing tumors that remained on the control diet , the buccal pouches of hamsters bearing tumors receiving turmeric showed the following results : ( 1 ) decreased cell proliferation ( diminished PCNA , cyclin D1 , and Bcl-2 ) and PCNA labelling index , ( 2 ) enhanced apoptosis ( increased Bax , caspase-3 , caspase-9 , and cytochrome c , and decreased survivin ) and apoptotic index , ( 3 ) decreased inflammation ( decreased Cox-2 ) , and ( 4 ) decreased [MAPK] *activation* ( and p-p38 ) . Positive_regulation MAPK7 EPHB2 23892041 2830340 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three [MAPK] *inhibitors* ( inhibitor PD98059 , JNK inhibitor SP600125 and p38 inhibitor SB203580 ) . Positive_regulation MAPK7 EPHB2 23914844 2840576 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 [MAPK] and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of , JNK , NF-?B . Positive_regulation MAPK7 EPHB2 23917355 2826047 Inhibition of Akt or activity *reduced* phosphorylation of STAT1 in Colon26L5-CUG2 cells whereas inhibition of p38 [MAPK] did not significantly decrease levels of STAT1 phosphorylation , indicating that cell proliferation signals may be involved in CUG2 mediated activation of STAT1 . Positive_regulation MAPK7 EPHB2 24225419 2897500 Therefore , by using the [MAPK] *inhibitors* SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific inhibitor ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation MAPK7 EPHB2 24297112 2894229 Following treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation MAPK7 F2R 16052512 1460030 The p38 and ERK1/2 [MAPK] signaling cascades were also *activated* by stimulation , whereas the SAPK/JNK pathway was unaffected . Positive_regulation MAPK7 F2R 16467309 1548163 and PAR-2 stimulation rapidly *activated* both ERK1/2 and [p38MAPK] , and pharmacological blockade of MEK with either PD98059 or U0126 or of p38MAPK by SB203580 or SB202190 strongly inhibited thrombin- and SLIGKV induced COX-2 expression and 6-keto-PGF1alpha formation . Positive_regulation MAPK7 F2R 21252088 2402890 In the present study , we show that FVIIa , upon binding to EPCR on endothelial cells , activates endogenous protease activated receptor-1 (PAR1) and induces mediated p44/42 [mitogen activated protein kinase (MAPK)] *activation* . Positive_regulation MAPK7 F2R 24052258 2867021 However , the distinct non-canonical tethered ligands unmasked by neutrophil elastase and proteinase-3 , as well as synthetic peptides with sequences derived from these novel exposed tethered ligands , selectively stimulated mediated [mitogen activated protein kinase] *activation* . Positive_regulation MAPK7 F2R 8635212 357990 These results support the notion that the *activates* [MAPK] through PKC dependent pathways and that the incremental activation of MAPK by TRAP over that induced by thrombin is the consequence of enhanced activation through the PKC limb of the phosphoinositide lipid pathway . Positive_regulation MAPK7 FAS 14576831 1156610 A more physiological inhibitor , the intracellular PP2A inhibitor protein I2 ( PP2A ) , protected transfected HeLa cells in a similar way from mediated apoptosis and induced *activation* of [MAPK] in I2 ( PP2A ) transfected cells . Positive_regulation MAPK7 FAS 15280387 1302537 We further demonstrate that this pro-apoptotic effect of CO was independent of reactive oxygen species production and involved inhibition in *induced* activation of the pro-survival ERK [MAPK] . Positive_regulation MAPK7 FAS 16507991 1529645 Here we show that binding of Fas ligand to *activates* p38 [MAPK] in CD8+ T cells and that activation of this pathway is required for Fas mediated CD8+ T-cell death . Positive_regulation MAPK7 FAS 19417161 2179815 GST-MDA-7 killing was , in parallel , dependent on inactivation of extracellular signal regulated kinase 1/2 and on *induced* p38 [mitogen activated protein kinase] and c-jun NH ( 2 ) -terminal kinase-1/2 signaling . Positive_regulation MAPK7 FAS 21613257 2454281 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Positive_regulation MAPK7 FAS 21975294 2492848 Caspase-8 activity has an essential role in *mediated* [MAPK] activation . Positive_regulation MAPK7 FAS 8977313 403351 IFN-alpha2 did not alter the *induced* activity of [Mitogen activated protein kinase (MAPK)] 1 and did not inhibit the Apo-1/Fas mediated proteolytic cleavage of ADP-ribosyltransferase , a substrate of Interleukin-beta1 converting enzyme ( ICE ) and homologues . Positive_regulation MAPK7 FHL1 23456229 2781822 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Positive_regulation MAPK7 FOXA1 22879989 2641687 An increase in IGFBP-3 , mediated by depletion of , *inhibited* phosphorylation of [MAPK] and Akt , and increased expression of the cell cycle regulators p21 and p27 . Positive_regulation MAPK7 FUT4 20506505 2307960 These data suggested that not only *activates* [MAPK] and PI3K/Akt signals , but also promotes the crosstalk among these signaling pathways . Positive_regulation MAPK7 GLP1R 21356521 2394820 activation by Exendin-4 ( Ex-4 ) *increased* PKA and [MAPK] activity and decreased phosphorylation of AMPK in NTS . Positive_regulation MAPK7 GPR115 10958680 725888 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK7 GPR115 11916960 945640 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK7 GPR115 9182581 435834 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK7 GPR115 9826186 550231 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK7 GPR132 10958680 725877 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK7 GPR132 11474113 841743 Activation of by LPC *increased* intracellular calcium concentration , induced receptor internalization , activated ERK [mitogen activated protein kinase] , and modified migratory responses of Jurkat T lymphocytes . Positive_regulation MAPK7 GPR132 11916960 945629 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK7 GPR132 9182581 435823 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on mediated *activation* of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK7 GPR132 9826186 550220 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK7 GPR87 10958680 725957 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK7 GPR87 11916960 945709 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK7 GPR87 9182581 435903 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on mediated *activation* of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK7 GPR87 9826186 550300 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK7 HBEGF 10544013 563928 also rapidly *activated* [MAPK] and induced cyclin D1 in mid-G1 with kinetics similar to TGFalpha . Positive_regulation MAPK7 HBEGF 11171084 783799 Both p42 [MAPK] activation and mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation MAPK7 HBEGF 15380451 1298485 *induced* phosphorylation of ERK , p38 [MAPK] and Akt , which were suppressed by ZD1839 . Positive_regulation MAPK7 HBEGF 17928891 1858629 We report that cellular stress with methyl-beta-cyclodextrin ( MBCD ) , a molecule that extracts membrane cholesterol and thereby disrupts the structure of lipid rafts , strongly *induces* the synthesis of ( HB-EGF ) in keratinocytes through the activation of p38 [mitogen activated protein kinase] . Positive_regulation MAPK7 HBEGF 18990151 2028928 *Activation* of [Erk/MAPK] by was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation MAPK7 HBEGF 19048624 2023721 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked [MAPK] signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 MAPK , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Positive_regulation MAPK7 HBEGF 19559571 2110509 *induced* phosphorylation of p42/p44 [MAPK] in a few minutes . Positive_regulation MAPK7 HBEGF 20739666 2345894 Moreover , *induced* a stronger and more sustained activation of both the [mitogen activated protein kinase] and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation MAPK7 HBEGF 24188029 2921112 Here , we show that *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , [Mapk/Erk] pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation MAPK7 HRH1 11959800 931446 1. Previous studies have shown that the *activates* p42/p44 [mitogen activated protein kinases (MAPK)] in DDT ( 1 ) MF-2 smooth muscle cells via a phosphatidylinositol 3-kinase (PI-3K) dependent pathway . Positive_regulation MAPK7 HRH1 17965772 1820344 is *required* for TCR mediated p38 [MAPK] activation and optimal IFN-gamma production in mice . Positive_regulation MAPK7 HRH1 17965772 1820358 Moreover , signaling at the time of TCR ligation was *required* for activation of p38 [MAPK] , a known regulator of IFN-gamma expression . Positive_regulation MAPK7 IFI27 16953232 1682593 RET2A mediated regulation of p18 and , but not of cyclins D1 and D2 , *requires* functional [mitogen activated protein kinase] signaling . Positive_regulation MAPK7 IL1B 10640438 577514 and TNF alpha also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK7 IL1B 10704772 673010 CPI-1189 inhibits *induced* [p38-mitogen activated protein kinase] phosphorylation : an explanation for its neuroprotective properties ? Positive_regulation MAPK7 IL1B 10775561 686649 *activated* p44/42 [MAPK] , and this activation was enhanced in the presence of N-acetyl-L-cysteine . Positive_regulation MAPK7 IL1B 10864897 705736 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK7 IL1B 10864897 705788 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by TNF-alpha and . Positive_regulation MAPK7 IL1B 10864897 705803 TNF-alpha- and *induced* [ ( 3 ) H ] -thymidine incorporation and phosphorylation of p42/p44 [MAPK] was completely inhibited by PD98059 ( an inhibitor of MEK1/2 ) , indicating that activation of MEK1/2 was required for these responses . Positive_regulation MAPK7 IL1B 10969830 728491 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Positive_regulation MAPK7 IL1B 11032891 740459 *induces* p38 [MAPK] phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation MAPK7 IL1B 11037878 741246 also *stimulated* phosphorylation of p38 [MAPK] , SAPK/JNK , and ATF-2 . Positive_regulation MAPK7 IL1B 11126408 759778 TNFalpha and IFNgamma potentiate *induced* [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK7 IL1B 11126408 759791 [Mitogen activated protein kinase (MAPK)] activity that is *induced* by has been suggested to signal nitric oxide dependent as well as nitric oxide independent beta-cell destructive pathways . Positive_regulation MAPK7 IL1B 11126408 759804 The aim of this study was to investigate if TNFalpha and IFNgamma signal through mitogen activated protein kinases in isolated rat islets of Langerhans and if they potentiate [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK7 IL1B 11126408 759817 Further , TNFalpha and IFNgamma were found to synergistically increase [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK7 IL1B 11399523 824265 Glucose potentiates *induced* p38 [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK7 IL1B 11509550 848377 Although and TNF-alpha each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK7 IL1B 11557585 861408 *activated* the three [mitogen activated protein kinase] ( extracellular signal regulated kinases 1 and 2 , c-Jun NH2-terminal kinase/stress activated protein kinase , and p38 ) and the Janus kinase (JAK)-signal transducer and activator of transcription pathways . Positive_regulation MAPK7 IL1B 11698472 878057 *induced* phosphorylation and activation of p38 [MAPK] and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation MAPK7 IL1B 11698472 878103 *induced* phosphorylation of ERK and JNK as well as p38 [MAPK] in human endothelial cells . Positive_regulation MAPK7 IL1B 11728947 884814 We showed a dramatic decrease in *induced* phosphorylation of p38 [MAPK] , not extracellular signal regulated kinases 1/2 or jun NH2-terminal kinase , in rat cultured mesangial cells by FR167653 . Positive_regulation MAPK7 IL1B 11775830 766442 Role of protein tyrosine kinase in *induced* activation of [mitogen activated protein kinase] in fibroblast-like synoviocytes of rheumatoid arthritis . Positive_regulation MAPK7 IL1B 11853544 913376 Interestingly , *induced* p38 [MAPK] activity was greatly enhanced in ( alg+ ) compared with ( alg- ) cells . Positive_regulation MAPK7 IL1B 12117921 964670 mRNA expression by neutrophils was not dependent on p38 MAPK , and p38 [MAPK] was not *activated* in neutrophils incubated with A. phagocytophila . Positive_regulation MAPK7 IL1B 12131776 966869 and TNF-alpha *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK7 IL1B 12139924 969401 Regarding intracellular signaling , *activated* the p38 mitogen activated protein kinase (MAPK) but not the p42/p44 [MAPK] and , when combined with growth factors , intensified p38 activation but inhibited the growth-factor induced p42/p44 activation . Positive_regulation MAPK7 IL1B 12356282 993890 induced p44/42 [mitogen activated protein kinase (MAPK)] *activation* was inhibited by the MAPK/extracellular signal regulated protein kinase ( MEK ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK7 IL1B 12417253 1012958 Sphondin ( 50 microM ) did not affect the *induced* activations of p44/42 [MAPK] , p38 MAPK , and JNK . Positive_regulation MAPK7 IL1B 12500176 1026692 These data suggest that the presence of retinal holes and may *lead* to activation of HGF , [mitogen activated protein kinases (MAPK)] , c-jun and extracellular matrix remodeling , resulting in proliferative and migratory cells in the wounded retina . Positive_regulation MAPK7 IL1B 12507586 1038426 In this study we evaluated the role of epigallocatechin-3-gallate ( EGCG ) , a green tea polyphenol which mimics its anti-inflammatory effects , in modulating the induced *activation* of [MAPK] 's in human chondrocytes . Positive_regulation MAPK7 IL1B 12649265 1080072 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant MKK6 or p38beta2 MAPK inhibited *induced* p38 [MAPK] activation , COX-2 gene expression , and PGE2 release . Positive_regulation MAPK7 IL1B 12727980 1086562 P38 [MAPK] phosphorylation was *increased* by in nondecidualized ESC , whereas the IL-1 beta induced increase was suppressed in the decidualized cells . Positive_regulation MAPK7 IL1B 12727980 1086575 Treatment with 8-bromo-cAMP reduced *induced* phosphorylation of p38 [MAPK] in nondecidualized ESC . Positive_regulation MAPK7 IL1B 12727980 1086589 In contrast , treatment with H89 , a protein kinase A inhibitor , reversed a reduction in *induced* p38 [MAPK] phosphorylation in the decidualized cells . Positive_regulation MAPK7 IL1B 12727980 1086603 The altered property of decidualized cells is thought to be caused by attenuation of *induced* p38 [MAPK] phosphorylation in a way that involves the activation of the cAMP/protein kinase A pathway . Positive_regulation MAPK7 IL1B 12882449 1116294 NAC ( 1 mM ) also decreased the *induced* activation of p38 [MAPK] . Positive_regulation MAPK7 IL1B 12952251 1137422 Using Western-blot analysis , no effect of cAMP was found on the *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK7 IL1B 12952251 1137436 No decrease was observed in *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK7 IL1B 14563491 1154865 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Positive_regulation MAPK7 IL1B 15039421 1251245 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of , and RIP2 dependent *activation* of NF-kappaB and p38 [MAPK] mediated by the caspase recruitment domain . Positive_regulation MAPK7 IL1B 15111866 1241244 We further demonstrated that p38 [MAPK] is *activated* by and PDGF with different kinetics and that p38 MAPK is required for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation MAPK7 IL1B 15208668 1281348 *induced* the activation of extracellular signal regulated kinases-1/2 and P38 [mitogen activated protein kinase (MAPK)] , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation MAPK7 IL1B 15341531 1291766 In accordance with these findings , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) , which was attenuated by U0126 , SB202190 , or SP600125 , respectively . Positive_regulation MAPK7 IL1B 15389584 1354324 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] and JNK which was attenuated by pretreatment with U0126 or SP600125 , respectively . Positive_regulation MAPK7 IL1B 15489374 1359428 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and JNK was attenuated by pretreatment with U0126 , SB-202190 , or SP-600125 , respectively . Positive_regulation MAPK7 IL1B 15755725 1403426 The inhibitory effect of on alpha ENaC expression was *mediated* by the activation of p38 [MAPK] in both rat and human ATII cells and was independent of the activation of alpha v beta6 integrin and transforming growth factor-beta . Positive_regulation MAPK7 IL1B 16033422 1436170 Intrathecal *leads* to a time dependent up-regulation of phosphorylated p38 ( p-p38 ) [MAPK] protein expression in the spinal cord 30-240 min following IL-1beta injection ( i.t. ) . Positive_regulation MAPK7 IL1B 16033422 1436184 However , pretreatment with a p38 MAPK inhibitor significantly reduced the *induced* p-p38 [MAPK] expression by 38-49 % , and nearly completely blocked the subsequent iNOS expression ( reduction by 86.6 % ) , NO production , and thermal hyperalgesia . Positive_regulation MAPK7 IL1B 16043966 1459746 Western blot analysis demonstrated that *increased* the activation of phosphorylated MEK and p38 [MAPK] in GH3 cells . Positive_regulation MAPK7 IL1B 16140882 1450810 *induced* phosphorylation of [p38-MAPK] , but not that of c-Jun-N-terminal kinase or extracellular regulated kinase , was most susceptible to inhibition by low doses of PFE , and the addition of PFE blocked the activity of p38-MAPK in a kinase activity assay . Positive_regulation MAPK7 IL1B 16141635 1454874 DHA stimulated both rapid and prolonged activation of p44/42 , but not p38 , [mitogen activated protein kinase (MAPK)] *induced* by and PMA . Positive_regulation MAPK7 IL1B 16153910 1455447 The kidney was analyzed for expression of tumor necrosis factor alpha , , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 [mitogen activated protein kinase] , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation MAPK7 IL1B 16452991 1611747 Western blots showed that and TNF-alpha *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK7 IL1B 16528573 1549433 The aim of this study was to investigate if Gadd45b prevents *induced* beta cell [MAPK] signalling and apoptosis . Positive_regulation MAPK7 IL1B 16645161 1604682 significantly *increased* the phosphorylation of p38 [MAPK] and cPLA(2) . Positive_regulation MAPK7 IL1B 16698013 1575659 JST ( 0.01-1 mg/ml ) also attenuated the expression of cyclooxygenase (COX)-2 and activation of p38 [MAPK] *induced* by and A beta ( 1-42 ) . Positive_regulation MAPK7 IL1B 16718462 1584914 A synthetic peptide , C3d , reported to bind NCAM , did not activate MAPK or Akt as reported in neurons but inhibited *induced* [MAPK] activity , thereby mimicking the effect of SU5402 . Positive_regulation MAPK7 IL1B 16718462 1584939 We suggest that NCAM signalling through FGFR is required for efficient IL-1beta pro-apoptotic signalling by facilitating induced [MAPK] *activation* downstream of the NF-kappaB-MAPK branching point . Positive_regulation MAPK7 IL1B 16718462 1584984 Further , these data identify a novel function of C3d as an inhibitor of NCAM induced FGFR activity and of *induced* [MAPK] activation in beta cells . Positive_regulation MAPK7 IL1B 16959849 1639703 *caused* an increase in the phosphorylation of ERK , but not [p38MAPK] or c-Jun N-terminal kinase . Positive_regulation MAPK7 IL1B 16964394 1611559 Inhibitors of p38 [MAPK] and/or JNK significantly suppressed VEGF secretion both in the *presence* and absence of , while inhibitors of COX-2 , ERK1/2 , and PI3-K did not . Positive_regulation MAPK7 IL1B 17208222 1695818 Thalidomide also suppressed *induced* p38 [mitogen activated protein kinase (MAPK)] activation , while a p38 MAPK inhibitor destabilized COX-2 mRNA and the cytoplasmic shuttling of HuR induced by IL-1beta . Positive_regulation MAPK7 IL1B 17311279 1719295 *stimulated* phosphorylation of p42/p44 [MAPK] , p38 MAPK , and JNK was attenuated by pretreatment with U0126 , SB202190 , SP600125 , or transfection with these dominant negative mutants of MEK , ERK , p38 and JNK , respectively . Positive_regulation MAPK7 IL1B 17390080 1716144 We have previously demonstrated that *induced* HBD-2 mRNA expression in A549 cells through activation of nuclear factor-kappaB (NF-kappaB) transcriptional factor as well as p38 [mitogen activated protein kinase (MAPK)] , c-Jun N-terminal kinase (JNK) , or phosphatidylinositol-3-kinase (PI3K) . Positive_regulation MAPK7 IL1B 17390080 1716167 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Positive_regulation MAPK7 IL1B 17390080 1716197 Triptolide inhibited *induced* [MAPK] phosphatase-1 expression at the transcriptional level and resulted in sustained phosphorylation of JNK or p38 MAPK , explaining the little effect of triptolide on IL-1beta induced phosphorylation of these kinases . Positive_regulation MAPK7 IL1B 17438131 1742784 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by TNF-alpha and , but not by ansiomycin or sorbitol . Positive_regulation MAPK7 IL1B 17559635 1753267 also *activated* extracellular signal regulated kinase , p38 [MAPK] , and c-Jun N-terminal kinase . Positive_regulation MAPK7 IL1B 17645739 1793275 Interestingly , Dex attenuated mediated *activation* of p38 [MAPK] and JNK , but not of AKT . Positive_regulation MAPK7 IL1B 17694686 1782117 IL-1beta induced NO levels and thermal hyperalgesia in rats , likely via either inhibiting the mediated p38 [MAPK] *activation* and subsequent iNOS induction , or direct attenuation of the central iNOS activity , which therefore reduces the central sensitization of inflammatory pain . Positive_regulation MAPK7 IL1B 17920534 1804195 SA981 at a concentration of 100 microM partially inhibited *induced* phosphorylation of [p38MAPK] and Akt ( 12.0 % and 36.1 % inhibition of each total amount of phosphoprotein under IL-1beta coexistence condition , respectively ) . Positive_regulation MAPK7 IL1B 17925024 1835159 *stimulated* phosphorylation of c-jun amino-terminal kinase , p38 [MAPK] and extracellular signal regulated kinase-1/2 . Positive_regulation MAPK7 IL1B 18026701 1827826 Moreover , glucosamine suppressed the *induced* phosphorylation of p38 [MAPK] ( p < 0.05 at > 0.1 mM ) and the IL-1beta binding to its receptors ( p < 0.05 at 1 mM ) . Positive_regulation MAPK7 IL1B 18065201 1853668 *stimulated* activation of ERK1/2 and p38alpha [MAPK] mediates the transcriptional up-regulation of IL-6 , IL-8 and GRO-alpha in HeLa cells . Positive_regulation MAPK7 IL1B 18348730 1925320 The *activation* or inhibition of p38 [MAPK] by and/or SB203580 was analyzed by western blotting . Positive_regulation MAPK7 IL1B 18348730 1925333 *activated* the phosphorylation of p38 [MAPK] and this effect was abolished by SB203580 . Positive_regulation MAPK7 IL1B 18427719 1920728 Phosphorylated p38 ( Phos-p38 ) [mitogen activated protein kinase] was *stimulated* in SW-1353 cells by but not by HA alone . Positive_regulation MAPK7 IL1B 18556347 1965941 or leptin individually *induced* threonine/tyrosine phosphorylation of p38 [MAPK] , whereas only leptin induced tyrosine phosphorylation of JAK2 , suggesting that leptin may enhance hBD-2 production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with NF-kappaB , which is activated by IL-1beta . Positive_regulation MAPK7 IL1B 18667841 1948057 Furthermore , induced p38 [mitogen activated protein kinase (MAPK)] *activation* and upregulation of VEGF-C mRNA and protein in LLC cells was also suppressed by artemisinin or by the p38 MAPK inhibitor SB-203580 , suggesting that p38 MAPK could serve as a mediator of proinflammatory cytokine induced VEGF-C expression . Positive_regulation MAPK7 IL1B 19362079 2081464 *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 [mitogen activated protein (MAP) kinase] , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation MAPK7 IL1B 19522843 2136344 In chondrocytes , CS diminishes *induced* increases in p38 [mitogen activated protein kinase] ( p38MAPK ) and signal regulated kinase 1/2 ( Erk1/2 ) phosphorylation , and decreases nuclear factor-kappaB (NF-kappaB) nuclear translocation and as a consequence , reduces the formation of pro-inflammatory cytokines , IL-1beta and TNF-alpha , and pro-inflammatory enzymes , such as phospholipase A2 (PLA2) , cyclooxygenase 2 (COX-2) and nitric oxide synthase-2 (NOS-2) . Positive_regulation MAPK7 IL1B 19765281 2163528 Treatment with PIP-18 blocked *induced* p38 [MAPK] phosphorylation and resulted in attenuation of sPLA2-IIA and MMP mRNA transcription in RA SF cells . Positive_regulation MAPK7 IL1B 20060906 2218526 In the present study , we demonstrate that *caused* activation of p38 [mitogen activated protein kinase] and that the p38 inhibitor SB203580 significantly blocked the effect of IL-1beta on I ( NMDA-OUT ) in hippocampal CA1 neurons . Positive_regulation MAPK7 IL1B 20353947 2266483 In model 1 , a differentiation model , CLA *activation* of [MAPK] and induction of interleukin-8 (IL-8) , IL-6 , , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation MAPK7 IL1B 21659536 2455199 Distinct roles for Nod2 protein and autocrine in muramyl dipeptide *induced* [mitogen activated protein kinase] activation and cytokine secretion in human macrophages . Positive_regulation MAPK7 IL1B 24692548 2935250 At 1 h , this was responsible for the dexamethasone inhibition of induced [MAPK] *activation* and CXCL1 and CXCL2 mRNA expression , with a similar trend for CSF2 . Positive_regulation MAPK7 IL1B 9475519 486796 Of these , *activated* only [MAPK] . Positive_regulation MAPK7 IL1B 9475519 486809 In cultured rat astrocytes , *caused* activation of [MAPK] without inducing proliferation . Positive_regulation MAPK7 IL1B 9575890 502750 Our data also indicate that both insulin and IGF-I enhance *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation and SAPK activation . Positive_regulation MAPK7 IL1B 9582321 503941 Previously we reported that *induces* activation of JNK/SAPK and p38 [MAPK] with concomitant up-regulation of cyclooxygenase (Cox)-2 expression and prostaglandin E2 ( PGE2 ) synthesis . Positive_regulation MAPK7 IL1B 9614146 509334 By Western blotting with phosphospecific antibodies and by immunocomplex kinase assay , was shown to *activate* extracellular signal regulated kinase ( ERK ) 1/2 and p38 [mitogen activated protein kinase] ( p38 ) in islets and rat insulinoma cells . Positive_regulation MAPK7 IL1B 9786861 540919 We reported previously that rapidly *activates* the c-Jun NH2-terminal/stress activated protein kinases ( JNK/SAPK ) and p38 [mitogen activated protein kinase (MAPK)] and also induces Cox-2 expression and prostaglandin E2 ( PGE2 ) production . Positive_regulation MAPK7 IL1B 9786861 540965 Overexpression of the kinase-dead form of MKK3 or MKK6 demonstrated that either of these two mutant kinases inhibited *induced* p38 [MAPK] phosphorylation and Cox-2 expression but not JNK/SAPK phosphorylation and activation . Positive_regulation MAPK7 ITGB2 12600815 1099084 IL-3 , IL-5 , and GM-CSF could enhance p38 [MAPK] and NF-kappaB activity and *induce* ICAM-1 , CD11b , and expressions on eosinophils . Positive_regulation MAPK7 ITGB2 19843511 2203206 Furthermore , beta2 integrins modulated the capacity of isolated peritoneal macrophages to take up acetylated LDL and native LDL and to phagocytose apoptotic cells , possibly via *dependent* [mitogen activated protein kinase] signalling . Positive_regulation MAPK7 LBP 20615568 2309966 Despite activating NFkappaB , NOD1 ligand did not upregulate hepatocyte production of the acute phase proteins lipopolysaccharide binding protein , serum amyloid A , or soluble CD14 in cell culture supernatants , or upregulate mRNA expression of , serum amyloid A , C-reactive protein , or serum amyloid P . NOD2 ligand ( MDP ) did not *activate* hepatocytes when given alone , but did synergize with Toll-like receptor ligands , lipopolysaccharide (LPS) , and polyI : C to activate NFkappaB and [MAPK] . Positive_regulation MAPK7 MAP2K6 10050043 592975 In one set of experiments , we *inhibited* the activation of [MAPK] by pretreating cells with PD098059 , a specific inhibitor of ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAPK7 MAP2K6 10079106 595497 Although MKK3 , MKK4 , and all *activated* p38 [MAPk] in experimental models , only MKK3 was found to activate recombinant p38 MAPk in LPS treated neutrophils . Positive_regulation MAPK7 MAP2K6 10471331 641660 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Positive_regulation MAPK7 MAP2K6 10601295 574425 In addition , *activation* of p38 [MAPK] by constitutively active or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAPK7 MAP2K6 10713051 674428 Conversely , the inhibitors PD98059 and UO126 could *attenuate* EGF induced [mitogen activated protein kinase] activation , they do not affect the EGF induced mobility shift of caveolin-1 . Positive_regulation MAPK7 MAP2K6 10759527 683194 These results demonstrate that a plant can phosphorylate and *activate* [MAPK] , and that Tyr phosphorylation is critical for the catalytic activity of MAPK in plants . Positive_regulation MAPK7 MAP2K6 10816593 714752 The MAPK kinase selectively *stimulates* p38 [MAPK] and confers protection against stress induced apoptosis in cardiac myocytes . Positive_regulation MAPK7 MAP2K6 10891559 711238 MAP kinases (MAPK) in both G-1 and G-5 cells were indistinguishably phosphorylated , yet dependent [MAPK] *activation* was observed only in G-5 cells . Positive_regulation MAPK7 MAP2K6 11005808 752465 A inhibitor , PD98059 , *inhibited* heat shock ERK [MAPK] activation by > 75 % . Positive_regulation MAPK7 MAP2K6 11085935 750745 Similarly , *activation* of JNK by Ad-MKK7D and [p38-MAPK] by resulted in the increased expression of PGHS-2 . Positive_regulation MAPK7 MAP2K6 11237743 790350 The MAPK kinase ( ) inhibitor , PD98059 , *blocked* GSA stimulated [MAPK] activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Positive_regulation MAPK7 MAP2K6 11304531 826848 The *activation* of p38 [MAPK] by Galpha ( q ) and Gbetagamma was blocked by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Positive_regulation MAPK7 MAP2K6 11787422 891972 Indeed the MAPK kinase ( = ) inhibitor PD98059 *inhibits* the activation of parasite [MAPK] , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Positive_regulation MAPK7 MAP2K6 11822870 909100 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of [MAPK] pathway *inhibitors* ( inhibitors PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAPK7 MAP2K6 12009309 940858 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Positive_regulation MAPK7 MAP2K6 12203369 983264 Furthermore , PKC inhibitors or an inhibitor completely *suppressed* both TPA induced activation of [MAPK] and promotion of anchorage independent growth , but a cPKC-selective inhibitor partially suppressed TPA induced promotion of the growth . Positive_regulation MAPK7 MAP2K6 12356282 993896 IL-1beta induced p44/42 [mitogen activated protein kinase (MAPK)] activation was *inhibited* by the MAPK/extracellular signal regulated protein kinase ( ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK7 MAP2K6 12377770 1019998 These results suggest that MKK3 , rather than , *mediates* alphav integrin induced p38 [MAPK] activation . Positive_regulation MAPK7 MAP2K6 12450322 1018682 ANG II significantly increased aldosterone release , and this effect was inhibited by the LO inhibitor baicalein , as well as a specific p38 [MAPK] *inhibitor* , SB202190 , but not by PD098059 , a specific inhibitor of the ERK activator . Positive_regulation MAPK7 MAP2K6 12637559 1085536 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Positive_regulation MAPK7 MAP2K6 12659851 1073554 MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a ( MAP2K ) , which in turn *activates* a [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK7 MAP2K6 12845643 1108634 Finally , both ODQ and UO126 blocked the capacity of L-arginine to restore ERK ( 1/2 ) phosphorylation in L-NAME treated cells , demonstrating that GC and are both *required* for endogenous NO-mediated [MAPK] activation . Positive_regulation MAPK7 MAP2K6 15104236 1240355 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( ) inhibitor , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAPK7 MAP2K6 15172888 1288432 Importantly , the presence of inhibitors only at the time of the transport assay markedly *impaired* both insulin stimulated glucose uptake and [MAPK] signaling . Positive_regulation MAPK7 MAP2K6 15172888 1288525 Conversely , removal of inhibitors before the transport assay *restored* glucose uptake and [MAPK] signaling . Positive_regulation MAPK7 MAP2K6 15304546 1322552 Furthermore , *activation* of [ERK/MAPK] by the coexpression of constitutively active predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAPK7 MAP2K6 15365248 1294610 Treatment of keratinocytes with PD98059 , inhibitor , and SB20358 , p38 [MAPK] *inhibitor* , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAPK7 MAP2K6 15570612 1355606 Although the inhibitors *suppressed* [MAPK] phosphorylation in both OA- and AICAR treated oocytes , meiotic resumption was not causally linked to MAPK phosphorylation in either group . Positive_regulation MAPK7 MAP2K6 15867183 1404248 In cultured cardiac myocytes , specific *activation* of stress activated [mitogen activated protein kinase] , p38 , by upstream activator led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAPK7 MAP2K6 15879307 1411363 Conversely , constitutively active *induced* p38 [MAPK] activation that recapitulated the effects of polyphenols by inducing ERalpha phosphorylation and downstream activation of Akt , and eNOS . Positive_regulation MAPK7 MAP2K6 16157033 1455802 SB203580 , a [P38MAPK] *inhibitor* , and U0126 , a inhibitor , both completely blocked ADM mediated responses in MsC . Positive_regulation MAPK7 MAP2K6 17416211 1777925 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK7 MAP2K6 18401006 1925879 CyaA enhanced LPS induced phosphorylation of p38 [MAPK] and ERK in DC , and inhibitors of p38 MAPK , , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation MAPK7 MAP2K6 18754769 1968478 ( MKK) 3 and 6 are the main p38 [mitogen activated protein kinase] *activators* in mammals . Positive_regulation MAPK7 MAP2K6 18771907 1962723 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a inhibitor , and SB203580 , an *inhibitor* of p38 [mitogen activated protein (MAP) kinase] , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAPK7 MAP2K6 18803286 2021161 NT3 stimulated phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2 and [ERK5] in the cortical progenitors , and the effects of NT3 on the increase in total BrdU positive cells and Pax6-/BrdU positive cells were *diminished* by an inhibitor , suggesting the involvement of MEK mediated ERK signal transduction in the NT3 actions . Positive_regulation MAPK7 MAP2K6 21892182 2491668 Further , we show that *activation* of p38 [MAPK] by expression of constitutively active ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAPK7 MAP2K6 22164285 2517916 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of and marked *activation* of p38 [MAPK] . Positive_regulation MAPK7 MAP2K6 22785235 2691936 TRH induced CRE promoter was inhibited by [mitogen activated protein kinase/ERK] kinase ( MEK ) inhibitor and was *increased* by overexpression of . Positive_regulation MAPK7 MAP2K6 7644477 318707 Inhibition of by PD 098059 *prevented* activation of [MAPK] and subsequent phosphorylation of MAPK substrates both in vitro and in intact cells . Positive_regulation MAPK7 MAP2K6 7822248 285640 ( MKK ) phosphorylates and *activates* [mitogen activated protein kinase (MAPK)] in response to stimulation of various eukaryotic signaling pathways . Positive_regulation MAPK7 MAP2K6 7889302 289484 2. Both nucleotides stimulate phosphorylation and *activation* of [mitogen activated protein kinase] and a biphasic phosphorylation of the up-stream . Positive_regulation MAPK7 MAP2K6 8180183 256284 This stimulation of the activator was temporally *followed* by increased activities of MEK and [MAPK] . Positive_regulation MAPK7 MAP2K6 8226933 235455 *Activation* of extracellular signal regulated kinase ( ERK ) or [mitogen activated protein kinase] by ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAPK7 MAP2K6 8394352 228285 We show that a similar activity phosphorylates and *activates* [MAPK] in both growth factor stimulated ( epidermal growth factor and thrombin ) and oncogene ( gip2 , v-src , and v-raf ) -transfected cells . Positive_regulation MAPK7 MAP2K6 8550616 346718 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Positive_regulation MAPK7 MAP2K6 8663100 368202 The [MAPK] and NHE activities induced by PMA were *inhibited* by staurosporine , a potent inhibitor for protein kinase C ( PKC ) , and by MAPK kinase ( ) inhibitor , PD98059 , but were not affected by the tyrosine kinase inhibitor genistein . Positive_regulation MAPK7 MAP2K6 8663100 368303 In contrast , both AVP induced [MAPK] and NHE activities were *inhibited* by genistein and inhibitor but were not affected by staurosporine . Positive_regulation MAPK7 MAP2K6 8816498 384339 *activates* [mitogen activated protein kinase (MAPK)] , which phosphorylates other kinases as well as transcription factors . Positive_regulation MAPK7 MAP2K6 9135064 427656 In addition to *dependent* [MAPK] activation , we provide evidence for MEK independent regulation of the MAPKs . Positive_regulation MAPK7 MAP2K6 9166761 432504 The first step in [MAPK] *activation* by must be the formation of a MEK x MAPK enzyme-substrate complex , followed by phosphorylation producing monophosphorylated MAPK ( pMAPK ) . Positive_regulation MAPK7 MAP2K6 9626658 511946 These results indicate that *mediates* the IGF-I/insulin induced p42/ p44 [MAPK] activation . Positive_regulation MAPK7 MAP2K6 9864179 582773 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of ERK , but not p38 [MAPK] , induced by G-CSF , GM-CSF , or TNF . Positive_regulation MAPK7 MMP7 16848631 1588331 and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 [mitogen activated protein kinase] activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MAPK7 MMP7 21999204 2547390 Mesothelin enhances invasion of ovarian cancer by *inducing* through [MAPK/ERK] and JNK pathways . Positive_regulation MAPK7 MUC16 11481474 843939 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a [mitogen activated protein kinase] ( Erk 1/2 ) , and *activation* of transcription . Positive_regulation MAPK7 PECAM1 18029285 1866927 In contrast , expression of Delta15 in PECAM-1-/- bEND cells *had* minimal effects on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Positive_regulation MAPK7 PGC 22105890 2599547 Our studies also revealed that overexpression of in cardiomyocytes *inhibited* basal and T3-induced p38 [MAPK] phosphorylation . Positive_regulation MAPK7 PIGR 20450283 2257153 Induction of expression in HT-29 cells *required* NF-kappaB signaling but not [MAPK] signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation MAPK7 PLAT 19436314 2107044 cerebrospinal fluid and brain parenchymal ERK [MAPK] was elevated by H/I and this upregulation was *potentiated* by , but blunted by RBC-tPA . Positive_regulation MAPK7 PLAT 21037505 2499500 Red blood blocked c-Jun-N-terminal kinase but *potentiated* p38 [mitogen activated protein kinase] upregulation after photothrombotic injury . Positive_regulation MAPK7 PLAU 10766865 684610 surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha [mitogen activated protein kinase] activity . Positive_regulation MAPK7 PLAU 15031204 1257174 In HeLa cells the dominant negative form of JNK interferes with the p42/p44 [MAPK] *activation* of the . Positive_regulation MAPK7 PLAU 15874933 1405703 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 [MAPK] , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Positive_regulation MAPK7 PLAU 15874933 1405736 Although *induced* phosphorylation of both ERK1/2 and p38 [MAPK] was blocked by Galphai inhibition , inhibition of PI3K and Ras decreased the uPA induced phosphorylation of ERK1/2 but not p38 MAPK . Positive_regulation MAPK7 PLAU 18656457 1960569 Exogenous administered at 4 h post H/I further *stimulated* ERK [MAPK] phosphorylation , which was blocked by RAP . Positive_regulation MAPK7 PLAU 9660790 517504 The receptor *mediates* tyrosine phosphorylation of focal adhesion proteins and activation of [mitogen activated protein kinase] in cultured endothelial cells . Positive_regulation MAPK7 PLAU 9660790 517517 The *induced* activation of [MAPK] was completely inhibited by genistein , but not by 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo [ 3 , 4-d ] pyrimidine , a specific inhibitor of Src family kinases . Positive_regulation MAPK7 PODXL 17616675 1769278 expression also *led* to an increase in [mitogen activated protein kinase (MAPK)] and phosphatidylinositol 3-kinase (PI3K) activity . Positive_regulation MAPK7 PODXL 17616675 1769325 These findings suggest that leads to increased in vitro migration and invasion , increased MMP expression , and *increased* activation of [MAPK] and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MAPK7 PTGER2 19233324 2072064 Further , PGE ( 2 ) , EP2A and EP4A did not increase BMP2/4 mRNA levels in RC cells , and *induced* phosphorylation of p38 [MAPK] was not eliminated by Noggin . Positive_regulation MAPK7 SLC38A3 15331357 1288042 In contrast , *stimulated* [MAPK] activation was blocked by > 80 % by dominant negative Ras but not by dominant negative Rho and Cdc42 . Positive_regulation MAPK7 SNCAIP 12639553 1068708 In addition , [MAPK] was *activated* by through Edg-1 , Sph-1-P receptor . Positive_regulation MAPK7 SPHK1 18602364 1941514 As a result , inhibition of by SKI *blocked* phosphorylation of p38 [MAPK] , showing that SPHK activation by IL-18 is an upstream signal of p38 MAPK activation . Positive_regulation MAPK7 STK39 17237610 1690346 The phosphorylation of cytoplasmic p38 [MAPK] in Akata cells was *reduced* by the inhibitor , 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperazine ( H7 ) . Positive_regulation MAPK7 TLR7 16424221 1515615 MKP-1-deficient macrophages also show enhanced constitutive and *induced* activation of p38 [MAPK] . Positive_regulation MAPK7 TLR7 23979601 2850695 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Positive_regulation MAPK7 TLR7 24879442 2941046 GIT2 terminates *induced* NF-?B and [MAPK] signaling by recruiting the deubiquitinating enzyme Cylindromatosis to inhibit the ubiquitination of TRAF6 . Positive_regulation MAPK7 TNF 10504489 648987 Pretreatment with SB203580 ( 10 microM ) had no effect on basal or TNF-alpha stimulated phosphorylation of p38 MAPK but completely abolished *stimulated* p38 [MAPK] activity . Positive_regulation MAPK7 TNF 10521481 653117 The study presented here shows that autoregulation of gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 [mitogen activated protein (MAP) kinase] activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation MAPK7 TNF 10570180 568165 Furthermore , LPS , UV irradiation , and *caused* activation of p38 [MAPK] whereas IFN-gamma did not . Positive_regulation MAPK7 TNF 10601128 574218 alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation MAPK7 TNF 10640438 577513 IL-1 beta and also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK7 TNF 10669634 665812 In this study , we show that *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation MAPK7 TNF 10753884 682347 Moreover , *stimulated* both the NF-kappaB and [mitogen activated protein (MAP) kinase] ( extracellular signal regulated kinase , c-Jun NH ( 2 ) -terminal kinase , and p38 MAP kinase ) signaling pathways in astrocytes . Positive_regulation MAPK7 TNF 10783388 707854 dependent p38 [MAPK] *activation* was detected in both Mo7e and Hut-78 cells and was blocked by the p38 MAPK inhibitor , SB203580 . Positive_regulation MAPK7 TNF 10783388 707907 SB203580 did not affect TNF-alpha signaled nuclear translocation and DNA binding activity of NF-kappaB , and inhibition of NF-kappaB function did not affect induced p38 [MAPK] *activation* , indicating that these events are not dependent on each other . Positive_regulation MAPK7 TNF 10864897 705735 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK7 TNF 10864897 705787 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by and IL-1beta . Positive_regulation MAPK7 TNF 11095634 755304 rapidly *activated* [MAPK] and increased the extent of attachment , spreading and migration on fibronectin and collagen type I ( P < 0.01 ) but not on collagen type IV . Positive_regulation MAPK7 TNF 11108246 756733 *activates* extracellular regulated kinase-1/2 ( ERK1/2 ) and [p38MAPK] . Positive_regulation MAPK7 TNF 11108836 757044 In RAW264 cells which differentiate into osteoclast-like multinucleated cells by TNF treatment alone , activation of p38 [mitogen activated protein (MAP) kinase] *induced* by murine was comparable to and independent of the receptor activator of necrosis factor-kappaB ligand . Positive_regulation MAPK7 TNF 11156586 780620 1. We have previously shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce interleukin-8 (IL-8) by human pulmonary vascular endothelial cells . Positive_regulation MAPK7 TNF 11167962 783071 It has previously been shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce cytokine , including RANTES , that N-acetylcysteine (NAC) attenuates cytokine production by human bronchial epithelial cells ( BECs ) , and that sensitivity to TNFalpha is inversely correlated with cellular redox state . Positive_regulation MAPK7 TNF 11266661 797174 However , *caused* no activation of p42/p44 [MAPK] or cytosolic phospholipase A(2) activity . Positive_regulation MAPK7 TNF 11277995 798116 *activates* extracellular regulated kinases ( ERKs ) and p38 [mitogen activated protein kinase] ( p38MAPK ) , and inhibits the expression of uncoupling protein-1 (UCP-1) and adipocyte-specific genes in rat fetal brown adipocytes . Positive_regulation MAPK7 TNF 11319753 806844 SB 203580 , a selective inhibitor of p38 MAPK , inhibited IL-1 and *induced* p38 [MAPK] activity and IL-6 production ( IC ( 50 ) s 0.3 -- 0.5 microM ) in osteoblasts and chondrocytes . Positive_regulation MAPK7 TNF 11319753 806877 In addition , IL-1 and also *activated* p38 [MAPK] in fetal rat long bones and p38 MAPK inhibitors inhibited IL-1- and TNF stimulated bone resorption in vitro in a dose dependent manner ( IC ( 50 ) s 0.3 -- 1 microM ) . Positive_regulation MAPK7 TNF 11435466 832534 However , the cytotoxic responses to daunorubicin and exogenous ceramide remain unaltered , as do the *induced* p42/p44 [MAPK] activation and CD54 expression . Positive_regulation MAPK7 TNF 11438547 843399 *activated* p38 [MAPK] and p44/p42 MAPK in wild-type but not in p60 ( -/- ) , p80 ( -/- ) , or p60 ( -/- ) p80 ( -/- ) macrophages . Positive_regulation MAPK7 TNF 11494147 846178 In this study we demonstrate that *triggers* only modest proliferation , as well as p44/p42 [mitogen activated protein kinase (MAPK)] and NF-kappaB activation , in MM.1S multiple myeloma ( MM ) cells . Positive_regulation MAPK7 TNF 11495721 846402 Furthermore , overexpression of dominant negative mutants , H-Ras-15A and Raf-N4 , significantly suppressed p42/p44 [mitogen activated protein kinase (MAPK)] activation *induced* by and PDGF-BB and attenuated the effect of TNF-alpha on BK-induced IP response , indicating that Ras and Raf may be required for activation of these kinases . Positive_regulation MAPK7 TNF 11509550 848375 Although IL-1 beta and each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK7 TNF 11592111 869671 Lipopolysaccharide (LPS) treatment of a microglial cell line ( N9 ) *induced* a time dependent activation of both p38 [mitogen activated protein kinase] ( p38 MAPK ) and nuclear factor-kappaB (NFkappaB) , with consequent increases in interleukin-1alpha (IL-1alpha) , , and nitric oxide ( NO ) production . Positive_regulation MAPK7 TNF 11694522 896419 *activated* the three mammalian [MAPK] , p44/42 , JNK , and p38 , in a distinct time- and concentration dependent manner . Positive_regulation MAPK7 TNF 11694522 896445 In conclusion , although *activates* all three known [MAPK] in human preadipocytes , only p44/42 and JNK appear to be involved in the regulation of lipolysis . Positive_regulation MAPK7 TNF 11750919 898177 Biochemical and immunocytochemical analysis showed that *activated* p38 mitogen activated protein kinase ( p38MAPK ) and c-Jun N-terminal kinase (JNK) but not p42/p44 [MAPK] . Positive_regulation MAPK7 TNF 11820362 908744 *activated* p38 [MAPK] and stimulated IL-6 secretion by MG-63 cells , and pre-incubation of cells with the p38 MAPK inhibitor abrogated TNF-alpha dependent IL-6 secretion . Positive_regulation MAPK7 TNF 11820362 908773 Transfection of IL-6 full-length and 5-deletion gene promoter reporter constructs indicated that p38 [MAPK] *activation* by enhanced IL-6 gene expression , and that the p38 MAPK-responsive region resided in the proximal 260-bp segment . Positive_regulation MAPK7 TNF 11820362 908809 In conclusion , although p38 [MAPK] *activation* by stimulates IL-6 secretion by MG-63 cells , it has opposing effects on c/EBPbeta and NFkappaB activity . Positive_regulation MAPK7 TNF 11930247 927424 The p44/42 [MAPK] activity was significantly *enhanced* by and the TNF-alpha effect was opposed by rhIL-10 . Positive_regulation MAPK7 TNF 11930247 927437 It is suggested that rhIL-10 can inhibit *induced* VSMC proliferation and phosphorylation of p44/42 [MAPK] . Positive_regulation MAPK7 TNF 12095140 960570 significantly increased permeability and *induced* p38 and ERK [MAPK] activation compared with controls ( P < 0.05 ) . Positive_regulation MAPK7 TNF 12114204 964000 *increased* the phosphorylation of p38 MAPK within 15 min. Anisomycin , an activator of p38 MAPK , increased p38 [MAPK] phosphorylation and decreased SP-A mRNA levels in a dose dependent manner . Positive_regulation MAPK7 TNF 12130576 966590 Phosphorylation of p38 [MAPK] was *induced* by RANKL , IL-1 , , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation MAPK7 TNF 12131776 966868 IL-1 beta and *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK7 TNF 12297009 991043 In this study , we examined the anti-apoptotic role of p38 [MAPK] that is *activated* by in neuronal PC12 cells . Positive_regulation MAPK7 TNF 12297009 991056 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Positive_regulation MAPK7 TNF 12393915 1025445 This model probiotic also inhibits *activation* of the pro-apoptotic [p38/mitogen activated protein kinase] by , interleukin-1alpha , or gamma-interferon . Positive_regulation MAPK7 TNF 12511413 1079052 The treatment of RAW264 cells with TSA and NaB inhibited *induced* nuclear translocation of NF-kappa B and sRANKL induced activation of p38 [mitogen activated protein kinase (MAPK)] signals . Positive_regulation MAPK7 TNF 12631113 1067621 Additional experiments examining the role of cAMP on MC fractalkine expression showed that the incubation of MCs with TNF-alpha and either db-cAMP or forskolin attenuated TNF-alpha stimulated fractalkine mRNA and protein expression , preceded by attenuation of *activated* phosphorylation of p42/44 [MAPK] , and c-Jun , but not phosphorylation of PKCzeta/iota or nuclear translocation of NF-kappaB . Positive_regulation MAPK7 TNF 12637577 1099323 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and *requires* p38 [MAPK] activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation MAPK7 TNF 12665666 1030376 This study was undertaken to examine the relationship between induced cardiomyocyte apoptosis and *activation* of p38 [mitogen activated protein kinase (MAPK)] through oxidative stress . Positive_regulation MAPK7 TNF 12665666 1030389 Corresponding to the apoptotic effect , at 10 ng/mL *caused* rapid phosphorylation of p38 [MAPK] in wild-type cardiomyocytes . Positive_regulation MAPK7 TNF 12694807 1080915 *induced* the phosphorylation of p44/p42 [mitogen activated protein (MAP) kinase] and p38 MAP kinase . Positive_regulation MAPK7 TNF 12731668 1086851 On the other hand , GM-CSF- or *induced* phosphorylation of ERK and p38 [MAPK] was unaffected by these inhibitors at the concentrations effective for the inhibition of O2- release and adherence . Positive_regulation MAPK7 TNF 12829618 1113810 However , *induced* [p38-MAPK] phosphorylation was markedly diminished in mkk3-/- vs mkk3+/+ hearts ( percent basal , 127+/-23 versus 540+/-267 , respectively , P=0.04 ) , suggesting an MKK independent activation mechanism by ischemia . Positive_regulation MAPK7 TNF 12844496 1149734 Rho inhibition decreases induced endothelial [MAPK] *activation* and monolayer permeability . Positive_regulation MAPK7 TNF 12844496 1149747 Because GTP binding proteins have been implicated in MAPK activation , we now hypothesize that the GTP binding protein Rho is a mediator of *induced* [MAPK] activation and increased endothelial permeability . Positive_regulation MAPK7 TNF 12844496 1149761 C3 transferase attenuated induced [MAPK] *activation* and blocked TNF induced endothelial permeability . Positive_regulation MAPK7 TNF 12867430 1142022 Subsequently , mediated p38 [MAPK] *activation* induced sialidase activity and CD44-HA binding . Positive_regulation MAPK7 TNF 12867430 1142111 Taken together , our results suggest that *induced* p38 [MAPK] activation may regulate the induction of functionally active HA-binding form of CD44 by activating sialidase in LPS stimulated human monocytic cells . Positive_regulation MAPK7 TNF 12881424 1116136 Importantly , does not induce ROS accumulation or prolonged MAPK activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently *induces* prolonged [MAPK] activation and necrotic cell death Positive_regulation MAPK7 TNF 12893778 1121034 We show that MKK3 and MKK6are essential for *stimulated* p38 [MAPK] activation . Positive_regulation MAPK7 TNF 12960255 1158292 To investigate a potential interplay between induced *activation* of p38 [MAPK] and NF-kappaB , the p38 MAPK inhibitor SB203580 and a dominant negative p38 MAPK mutant were used . Positive_regulation MAPK7 TNF 14516792 1147208 [MAPK] pathway *activation* via was confirmed by marked AP-1 activation detected in EMSA . Positive_regulation MAPK7 TNF 14561851 1165110 In cultured human umbilical vein endothelial cells ( HUVECs ) , and lipopolysaccharide *increased* phosphorylation of p38 [MAPK] ( P-p38 MAPK ) and increased ICAM-1 expression . Positive_regulation MAPK7 TNF 14592823 1209469 Analyzing the individual contribution of PF-4 and its costimuli in the control of these functions at the signaling level , we demonstrate that *induced* activation of p38 [mitogen activated protein (MAP) kinase] ( but not extracellular regulated kinase [ Erk ] kinases ) acts as general and essential costimulatory signal in PF-4 dependent neutrophil exocytosis . Positive_regulation MAPK7 TNF 14632659 1170655 *activated* p38 [MAPK] in DCs only at an early time-point ( 15 min ) . Positive_regulation MAPK7 TNF 14654378 1176833 These findings suggest that the pre-ischemic *activation* of [p38-MAPK] by does not contribute to cardioprotection afforded by this agent . Positive_regulation MAPK7 TNF 14978743 1213705 Bacterial lipopolysaccharide (LPS) and neither *activate* [ERK5] nor require MEKK2 for JNK activation , demonstrating specificity of MEKK2 in FGF-2 receptor signaling and control of cytokine gene expression . Positive_regulation MAPK7 TNF 15002040 1265090 Consistent with the abrogation of osteoclastogenic effect of DcR3 by TNFR-Fc , DcR3 treatment can *induce* osteoclastogenic cytokine release through ERK and p38 [MAPK] signaling pathways . Positive_regulation MAPK7 TNF 15139014 1246962 The increase in release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not [mitogen activated protein kinase (MAPK)] , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation MAPK7 TNF 15191888 1295244 Treatment of endothelial cells with SphK1 siRNA suppressed *induced* increase in MCP-1 mRNA levels , MCP-1 protein secretion , and activation of p38 [MAPK] . Positive_regulation MAPK7 TNF 15212763 1262326 Interestingly , Ad5NIK , but not , *induces* RelA S536 and p38 [mitogen activated protein kinase (MAPK)] phosphorylation in IKKgamma ( -/- ) cells . Positive_regulation MAPK7 TNF 15233873 1269395 A. semen also inhibited the expression of and the *activation* of [mitogen activated protein kinase] , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation MAPK7 TNF 15240695 1270287 TNF activates Syk protein tyrosine kinase leading to induced [MAPK] *activation* , NF-kappaB activation , and apoptosis . Positive_regulation MAPK7 TNF 15240695 1270307 TNF induced Syk activation was abolished by piceatannol ( Syk-selective inhibitor ) , which led to the suppression of *induced* activation of c- JNK , p38 [MAPK] , and p44/p42 MAPK . Positive_regulation MAPK7 TNF 15240695 1270323 Jurkat cells that did not express Syk ( JCaM1 , JCaM1/lck ) showed lack of *induced* Syk , JNK , p38 MAPK , and p44/p42 [MAPK] activation , as well as TNF induced IkappaBalpha phosphorylation , IkappaBalpha degradation , and NF-kappaB activation . Positive_regulation MAPK7 TNF 15240695 1270354 Overall , our results demonstrate that Syk activation plays an essential role in *induced* activation of JNK , p38 [MAPK] , p44/p42 MAPK , NF-kappaB , and apoptosis . Positive_regulation MAPK7 TNF 15240725 1270462 p38 [MAPK] was *activated* by and oxidants in nonadherent conditions i.e. , with 10 mM EDTA . Positive_regulation MAPK7 TNF 15240725 1270476 Finally , p38 [MAPK] *activation* by was blocked by diphenylene iodonium , an inhibitor of flavoprotein oxidoreductase , and by the free radical scavenger N-acetylcystein . Positive_regulation MAPK7 TNF 15265936 1275738 Besides NF-kappa B , celecoxib also suppressed *induced* JNK , p38 [MAPK] , and ERK activation . Positive_regulation MAPK7 TNF 15290420 1278555 Halothane or isoflurane augmented the LPS- and *induced* activation of p38 [MAPK] . Positive_regulation MAPK7 TNF 15304089 1284484 DNCB , NiSO ( 4 ) and *activated* p38 [mitogen activated protein kinases (MAPK)] and c-jun N-terminal kinase ( JNK ) . Positive_regulation MAPK7 TNF 15322069 1333426 We have also investigated the phosphorylation of p42/44 [MAPK] and *upregulation* of RhoA protein by . Positive_regulation MAPK7 TNF 15452110 1341997 In contrast , *induced* p42/p44 [MAPK] activation and CD54 expression remained unaltered . Positive_regulation MAPK7 TNF 15589482 1356217 In addition , luteolin inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , IkappaB degradation , and NF-kappaB activation . Positive_regulation MAPK7 TNF 15659876 1350316 The anabolic effect of was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an extracellular regulated kinases (ERK) . Positive_regulation MAPK7 TNF 15696169 1372170 Using TCPTP-deficient fibroblasts , we show here that TCPTP regulates *induced* [MAPK] but not NF-kappaB signaling . Positive_regulation MAPK7 TNF 15696169 1372206 These results link TCPTP and Src tyrosine kinases to the selective regulation of *induced* [MAPK] signaling and identify a previously unknown mechanism for modulating inflammatory responses mediated by TNF . Positive_regulation MAPK7 TNF 15703956 1497473 *Activation* of p38 [mitogen activated protein (MAP) kinase] and phosphatidylinositol 3-kinase (PI3K) by was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation MAPK7 TNF 15792609 1386799 By stimulation of in AM-1 cells , the phosphorylation of Akt ( Ser473 ) and p44/42 [mitogen activated protein kinase (MAPK)] ( Thr202/Tyr204 ) was markedly *increased* in TNFalpha concentration and time dependent manner . Positive_regulation MAPK7 TNF 15792609 1386812 Pretreatment with U0126 , mitogen activated extracellular regulated kinase ( MEK) 1/2 inhibitor , prior to TNFalpha stimulation , specifically inhibited *induced* phosphorylation of p44/42 [MAPK] ( Thr202/Tyr204 ) in AM-1 cells . Positive_regulation MAPK7 TNF 15792609 1386828 Meanwhile , pretreatment with LY294002 , phosphatidylinositol-3-OH kinase (PI3K) inhibitor , could inhibit both *induced* phosphorylation of Akt ( Ser473 ) and p44/42 [MAPK] ( Thr202/Tyr204 ) . Positive_regulation MAPK7 TNF 15823554 1393917 Furthermore , potently *activated* p38 [MAPK] , JNK , and NF-kappaB . Positive_regulation MAPK7 TNF 15837794 1432554 Expression of this protein inhibited *induced* activation of NFkappaB , JNK , and p38 [MAPK] and sensitized the cells to TNF induced apoptosis . Positive_regulation MAPK7 TNF 15845648 1425552 *induces* a more than tenfold increase in p38 [mitogen activated protein kinase (MAPK)] but not extracellular signal regulated kinase phosphorylation . Positive_regulation MAPK7 TNF 15870903 1405552 In addition , GA inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , I kappa B alpha degradation , and NF-kappa B activation . Positive_regulation MAPK7 TNF 16009485 1441413 Moreover , p44/42 [mitogen activated protein kinase] appears to partly *mediate* the negative effect of insulin but not on ATGL . Positive_regulation MAPK7 TNF 16023081 1441593 Ellagic acid inhibited IL-1beta- and induced *activation* of activator protein-1 and mitogen activated protein kinases ( extracellular signal regulated kinase , c-Jun N-terminal kinase and p38 [mitogen activated protein kinase] ) , but not of nuclear factor-kappaB . Positive_regulation MAPK7 TNF 16025396 1435616 *activated* the phosphorylation of p44/42 MAPK , p38 [MAPK] , SAPK/JNK and Akt in mesangial cells . Positive_regulation MAPK7 TNF 16025396 1435632 PGE1 inhibited the *induced* phosphorylation of SAPK/JNK and Akt , but not p44/42 MAPK and p38 [MAPK] . Positive_regulation MAPK7 TNF 16080915 1442772 Comparative gene array analysis of *induced* [MAPK] and NF-kappaB signaling pathways between retinal ganglion cells and glial cells . Positive_regulation MAPK7 TNF 16140562 1499258 These results suggested that TNFalpha induced both cell survival and apoptosis pathways in ameloblastoma and potential of TNFalpha in inducing apoptosis can be improved by inhibiting *induced* Akt and p44/42 [mitogen activated protein kinase (MAPK)] cell survival pathways . Positive_regulation MAPK7 TNF 16275991 1480310 Angiotensin II , , or epidermal growth factor *induced* [MAPK] phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation MAPK7 TNF 16291729 1526075 *Activation* of [MAPK] and Akt by anti-HER2/neu inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation MAPK7 TNF 16314440 1487004 treatment *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation in NPCs , and SB202190 , an inhibitor of p38 MAPK , blocked TNF-alpha induced chemokine production . Positive_regulation MAPK7 TNF 16325162 1511669 Furthermore , APE1/ref-1 overexpression inhibited the *induced* increase in intracellular superoxide and p38 [MAPK] phosphorylation . Positive_regulation MAPK7 TNF 16452991 1611746 Western blots showed that IL-1beta and *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK7 TNF 16517732 1530946 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of , but not IL-6 , *requires* the activity of p38 [MAPK] . Positive_regulation MAPK7 TNF 16573652 1556141 HA-mediated production *required* p38 [MAPK] , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation MAPK7 TNF 16682409 1584062 Further , the deletion of NQO1 abolished *induced* c-Jun N-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] activation . Positive_regulation MAPK7 TNF 16781693 1585620 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and and the *activation* of [MAPK] 's are potentially positive signals for IL-10 production . Positive_regulation MAPK7 TNF 16798728 1638539 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Positive_regulation MAPK7 TNF 16875982 1593567 *activates* [p38-MAPK] , a stress-responsive kinase implicated in contractile depression and cardiac injury . Positive_regulation MAPK7 TNF 16875982 1593581 Under conditions of constant coronary flow , the [p38-MAPK] activation and contractile depression *induced* by , though attenuated , remained sensitive to the absence of MKK3 or the presence of SB203580 . Positive_regulation MAPK7 TNF 16875982 1593595 *activates* [p38-MAPK] in the intact heart and in isolated cardiac myocytes through MKK3 . Positive_regulation MAPK7 TNF 16982923 1617367 Compared with wild-type cells , MIF-deficient cells were hyporesponsive to IL-1- and *induced* [MAPK] activity , AP-1 activity , and cellular proliferation , while NF-kappaB function was preserved . Positive_regulation MAPK7 TNF 17070777 1649842 Inhibition of Syk down-regulated *induced* p38 and p44/42 [MAPK] phosphorylation and nuclear translocation of p65 NF-kappaB . Positive_regulation MAPK7 TNF 17099067 1676205 Importantly , Dex is able to increase the expression of MKP-1 , which causes an inactivation of *induced* p38 [MAPK] and mediates inhibition of E-selectin expression . Positive_regulation MAPK7 TNF 17126899 1677678 Stimulation of ECs with *induced* rapid increases in the phosphorylation of their mitogen activated protein kinases ( MAPKs ) [ extracellular signal regulated kinase ( ERK ) , c-Jun-NH2-terminal kinase (JNK) , and p38 [MAPK] ] ; Positive_regulation MAPK7 TNF 17126905 1686557 Differential regulation of and GM-CSF *induced* activation of P38 [MAPK] in neutrophils and eosinophils . Positive_regulation MAPK7 TNF 17138860 1653551 The role of delta-PKC in mediated *activation* of [MAPK] is not known . Positive_regulation MAPK7 TNF 17138860 1653577 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 MAPK are involved in TNF antiapoptotic signaling and whether delta-PKC is a key regulator of [MAPK] *activation* by . Positive_regulation MAPK7 TNF 17138860 1653603 In human neutrophils , *activated* both p38 [MAPK] and ERK1/2 principally via TNFR-1 . Positive_regulation MAPK7 TNF 17158449 1694269 A green fluorescent protein fusion protein containing the last 100 residues of TAK1 ( TAK1-C100 ) abolished the interaction of endogenous TAB2/TAB3 with TAK1 , the phosphorylation of TAK1 , and prevented the activation of IKK and [MAPK] *induced* by IL-1 , , and RANKL . Positive_regulation MAPK7 TNF 17161959 1694543 Upon examination of the signaling components , we found that was a potent *activator* of p38 , p44/42 , p54/46 [MAPK] , and IkappaBalpha ( IkappaBalpha ) . Positive_regulation MAPK7 TNF 17172975 1679391 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the [MAPK] , and production of . Positive_regulation MAPK7 TNF 17172975 1679417 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the [MAPK] , and production of . Positive_regulation MAPK7 TNF 17189827 1680175 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Positive_regulation MAPK7 TNF 17202326 1680819 Augmented lipopolysaccharide induced production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK7 TNF 17202326 1680845 In this study , we show that augmented LPS induced production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK7 TNF 17218473 1732525 The RhoA inhibitor C3 exoenzyme and the ROCK inhibitor Y-27632 both attenuated *induced* [MAPK] activation and blocked AR expression in HIMEC . Positive_regulation MAPK7 TNF 17220297 1703058 TRAF2 and ASK1 play essential roles in *induced* [mitogen activated protein kinase] signaling . Positive_regulation MAPK7 TNF 17258890 1725462 The effects of and FasL on GrB expression were specifically *mediated* by [p38MAPK] ( Mitogen-activated-protein-kinase ) activation . Positive_regulation MAPK7 TNF 17425653 1748788 The percentage increases in IL-18 induced phosphorylation of extracellular signal regulated kinase ( ERK ) in Th cells of NDN and DN were significantly higher than controls ( P < 0.05 ) , while the percentage increase in *induced* phosphorylation of p38 [MAPK] in monocytes and IL-18 induced phosphorylation of p38 MAPK in Th cells and monocytes were significantly higher in NDN patients than controls . Positive_regulation MAPK7 TNF 17438131 1742783 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation MAPK7 TNF 17438336 1749080 FAK promoted *stimulated* [MAPK] activation needed for maximal IL-6 production . Positive_regulation MAPK7 TNF 17438336 1749105 Analysis of FAK ( -/- ) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity , Tyr-397 phosphorylation , and the Pro-712/713 proline-rich region of FAK were required for *stimulated* [MAPK] activation and IL-6 production . Positive_regulation MAPK7 TNF 17446186 1749515 *increased* p38 [MAPK] phosphorylation , potently stimulated IRS-1 serine phosphorylation , and blunted insulin stimulated IRS-1 tyrosine and Akt phosphorylation and eNOS activity . Positive_regulation MAPK7 TNF 17531219 1762175 On the other hand , aloe emodin did not affect induced *activation* of p38 [mitogen activated protein kinase] or generation of reactive oxygen species . Positive_regulation MAPK7 TNF 17607712 1798194 Although *induced* the activation of p38 [MAPK] , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation MAPK7 TNF 17725582 1801639 MAC inhibited induced p38 [mitogen activated protein kinase] *activation* and cell death in cultured Schwann cells . Positive_regulation MAPK7 TNF 17895408 1823970 IA did not interfere with *induced* activation of c-Jun N-terminal kinase (JNK) and p38 [mitogen activated protein kinase] . Positive_regulation MAPK7 TNF 17942934 1814219 Deletion of NQO2 also abolished *induced* c-Jun NH2-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] activation . Positive_regulation MAPK7 TNF 17994109 1851167 triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 [MAPK] , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation MAPK7 TNF 18039275 1828533 Further downstream in this axis of signalling , blockade *reduces* only acute bronchoconstriction , while [MAPK] inhibition abrogates completely endotoxin induced inflammation . Positive_regulation MAPK7 TNF 18060043 1853607 In cultures of Schwann cells , astrocytes , and microglia , sLRP-alpha inhibited induced *activation* of p38 MAPK and [ERK/MAPK] . Positive_regulation MAPK7 TNF 18061162 1861521 We demonstrate that *induced* proliferation of C4HD murine mammary tumor cells and of T47D cells through the activation of p42/p44 [MAPK] , JNK , PI3-K/Akt pathways and nuclear factor-kappa B (NF-kappa B) transcriptional activation . Positive_regulation MAPK7 TNF 18091748 1847372 *induced* phosphorylation of extracellular signal regulated kinase ( ERK ) and Akt , but not p38 [mitogen activated protein kinase (MAPK)] , was attenuated by nicardipine , cilnidipine , benidipine , efonidipine , and azelnidipine . Positive_regulation MAPK7 TNF 18227157 1884374 It was shown that these three proteins could ( i ) induce expression of and tissue factor and ( ii ) *induce* phosphorylation of p44/42 [mitogen activated protein kinases (MAPK)] and activation of early growth response factor 1 (Egr-1) . Positive_regulation MAPK7 TNF 18258304 1884801 However , over-expression of a dominant negative form of Rac strongly inhibited induced p42/44 [MAPK] kinase *activation* , but had little effect upon JNK and no effect upon p38 MAPK activity . Positive_regulation MAPK7 TNF 18287053 1872494 Here , we show that the murine CMV M45 protein binds to RIP1 and inhibits *induced* activation of NF-kappaB , p38 [MAPK] , and caspase independent cell death . Positive_regulation MAPK7 TNF 18287248 1896530 Flavopiridol suppresses induced *activation* of activator protein-1 , c-Jun N-terminal kinase , p38 [mitogen activated protein kinase (MAPK)] , p44/p42 MAPK , and Akt , inhibits expression of antiapoptotic gene products , and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells . Positive_regulation MAPK7 TNF 18314542 1931911 P < 0.05 ) , and MKP-1 up-regulation was temporally related to the inhibition of *induced* p38 [MAPK] phosphorylation . Positive_regulation MAPK7 TNF 18336852 1912245 *stimulated* phosphorylation of p42/p44 [MAPK] and JNK were attenuated by pretreatment with the inhibitors U0126 and SP600125 or transfection with dominant negative mutants of DeltaERK and DeltaJNK . Positive_regulation MAPK7 TNF 18364436 1912773 We , for the first time , demonstrate that binding of staphylococcal enterotoxin B to MHC-II results in activation of TNF-alpha converting enzyme , epidermal growth factor receptor , [p38MAPK] , and NF-kappaB *inducing* biphasic production . Positive_regulation MAPK7 TNF 18443205 1938531 Conversely , *induced* increases in insulin receptor substrate-1 serine phosphorylation ( Ser ( 312 ) ) , Jun NH ( 2 ) -terminal kinase phosphorylation , and extracellular signal related kinase-1/2 [mitogen activated protein kinase (MAPK)] phosphorylation were unaltered by siRNA mediated IKKbeta reduction . Positive_regulation MAPK7 TNF 18518937 1971925 Although Cot/Tpl2 was phosphorylated in IRI and in the cultured tubular epithelial cells (TEC) after stimulation with LPS and hydrogen peroxide , there were no significant differences in terms of production , neutrophil infiltration or [MAPK] *activation* between Cot/Tpl2 ( +/+ ) and Cot/Tpl2 ( -/- ) mice . Positive_regulation MAPK7 TNF 18636175 1937275 Furthermore , glucosamine inhibited the *induced* phosphorylation of [p38MAPK] and NF-kappaB p65 , and the nuclear translocation of NF-kappaB in the cells . Positive_regulation MAPK7 TNF 18653803 1960522 PMA stimulated nSMase2 translocation was independent of p38 MAPK , and neither PKC inhibitors nor small interfering RNA had significant effects on *stimulated* p38 [MAPK] activation , indicating that PKC-delta does not act through p38 MAPK in regulating nSMase2 . Positive_regulation MAPK7 TNF 18710428 2028206 As for the signalling pathway , stimulation *led* to the phosphorylation of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and translocation of nuclear factor kappaB (NF-kappaB) ( p65 ) into the nuclei . Positive_regulation MAPK7 TNF 18710428 2028233 These data suggest that interaction *leads* to the phosphorylation of Erk1/2 and [p38MAPK] and nuclear translocation of NF-kappaB , which is closely associated with the production and activation of MMP-9 in cultured CC cells of HuCTT-1 and CCKS-1 . Positive_regulation MAPK7 TNF 18768892 1957234 Consistently , Nod2-null macrophages tolerant to LPS and MDP showed enhanced production of and IL-6 as well as increased NF-kappaB and [MAPK] *activation* in response to the dipeptide KF1B , the Nod1 agonist . Positive_regulation MAPK7 TNF 18948845 2053245 Hypertonic saline did not alter *induced* p38 [mitogen activated protein kinase] phosphorylation or constitutive vascular endothelial growth factor expression , suggesting that the observed inhibition is not a generalized suppression of protein phosphorylation or cellular function . Positive_regulation MAPK7 TNF 19100731 2031226 at 30 ng/ml significantly *increased* phosphorylation of receptor tyrosine kinase ( 175 kDa ) and p42 [mitogen activated protein (MAP) kinase] . Positive_regulation MAPK7 TNF 19130554 2025305 Stimulation of HIMEC with *triggered* phosphorylation of the [MAPK] , and up-regulation of VCAM-1 , FKN and ICAM-1 . Positive_regulation MAPK7 TNF 19234337 2079515 Analysis of downstream signals showed that inhibition of NAD(P)H oxidase partially inhibited NF-kappaB activation but did not reduce CCL2 mRNA stability or prevent *induced* phosphorylation of [p38MAPK] . Positive_regulation MAPK7 TNF 19275968 2072849 *stimulated* the phosphorylation levels of p38 [MAPK] , JNK , ERK1/2 and Akt in vascular endothelial cells . Positive_regulation MAPK7 TNF 19289468 2073043 The requirement for MADD was highly specific for induced *activation* of [MAPK] but not the related JNK and p38 kinases . Positive_regulation MAPK7 TNF 19371952 2081767 Of note , the IFN-gamma plus *stimulated* activation of p38 [MAPK] was suppressed following incubation with forskolin or DBcAMP alone . Positive_regulation MAPK7 TNF 19410630 2089700 By transfection of TAK1 siRNA , *induced* phosphorylation of IkappaBalpha , JNK1/2 , and [p38MAPK] , as well as IL-6 or IL-8 expression , were repressed . Positive_regulation MAPK7 TNF 19427347 2106799 *induced* the phosphorylation of p38 [mitogen activated protein (MAP) kinase] , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation MAPK7 TNF 19429670 2106873 Ang II and clearly *enhanced* ERK and [p38MAPK] phosphorylation . Positive_regulation MAPK7 TNF 19563733 2122013 Finally , EZS inhibited *induced* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phosphorylation . Positive_regulation MAPK7 TNF 19648110 2138336 This correlates with reduced *stimulated* p38 [MAPK] phosphorylation . Positive_regulation MAPK7 TNF 19648110 2138351 Repression of *induced* p38 [MAPK] phosphorylation , NF-kappaB dependent transcription , and IL-8 expression by dexamethasone are sensitive to transcriptional or translational inhibitors . Positive_regulation MAPK7 TNF 19648110 2138422 Thus , MKP-1 attenuates *dependent* activation of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Positive_regulation MAPK7 TNF 19648110 2138449 Small interfering RNA knockdown of dexamethasone induced MKP-1 expression partially reverses the repression of *activated* p38 [MAPK] , demonstrating that MKP-1 participates in the dexamethasone dependent repression of this pathway . Positive_regulation MAPK7 TNF 19788916 2163927 Tumor necrosis factor ( ) and H ( 2 ) O ( 2 ) *activate* [mitogen activated protein kinase (MAPK)] in SH-SY5Y cells within 5 min and this activation is completely blocked by DLPC ( 12 microM ) . Positive_regulation MAPK7 TNF 19877072 2160716 CpdA also displayed profound effects on *induced* [MAPK] activation . Positive_regulation MAPK7 TNF 19877072 2160733 In sharp contrast , DEX did not affect *induced* IKK phosphorylation , IkappaBalpha degradation , p65 nuclear translocation , or [MAPK] activation in RA FLS . Positive_regulation MAPK7 TNF 19889458 2197308 Calpain inhibition induces random migration in TNF-alpha stimulated cells and prevents the generation of reactive oxygen species , but does not alter mediated *activation* of p38 [MAPK] and ERK MAPK . Positive_regulation MAPK7 TNF 20231691 2237863 TNF-alpha treatment resulted in the phosphorylation of p38 MAPK and its downstream target , MAPK activated protein kinase-2 , but IFN-gamma did not affect the levels of [MAPK] and MAPK activated protein kinase-2 phosphorylation *induced* by . Positive_regulation MAPK7 TNF 20489729 2327425 *induced* activation of p38 [MAPK] and the production of inducible nitric oxide synthase were suppressed in ASK1-deficient Müller glial cells . Positive_regulation MAPK7 TNF 20646342 2292554 Effects of budesonide on P38 [MAPK] activation , apoptosis and IL-8 secretion , *induced* by and Haemophilus influenzae in human bronchial epithelial cells . Positive_regulation MAPK7 TNF 20646342 2292582 induced a significant *increase* in p38 [MAPK] phosphorylation . Positive_regulation MAPK7 TNF 20693316 2351483 In four of the six donors , basal and *induced* ERK and p38 [MAPK] activation were higher in ASMA than ASMNA cells . Positive_regulation MAPK7 TNF 20696856 2351514 Surprisingly , replenishment with exogenous GSH normalizes both *dependent* NF-?B as well as [MAPK] signaling and rescues hepatocytes from FKB induced death . Positive_regulation MAPK7 TNF 20951126 2364971 Taken together , this study provided first evidence demonstrating that TRAIL- , , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK7 TNF 21123734 2377727 The ability of CO to inhibit *induced* ERK1/2 and p38 [MAPK] activities in an Akt dependent manner appears to be the key element in ROS dependent survival of endothelial cells during TNF-a mediated brain inflammatory disease . Positive_regulation MAPK7 TNF 21181166 2499619 IL-1ß and *activated* the intracellular mitogen activated protein kinases ( MAPKs ) : p44/42 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) as well as nuclear factor-?B ( NF-?B ) in osteoblasts . Positive_regulation MAPK7 TNF 21285293 2425734 Inhibitors of NADPH oxidase and/or p47phox siRNA diminished ROS production and COX-2 expression as well as phosphorylation of p38 [mitogen activated protein kinase] ( p38MAPK ) and Akt *mediated* either by AS serum or by . Positive_regulation MAPK7 TNF 21336587 2457994 Effects of preconditioning with sevoflurane on *induced* permeability and activation of p38 [MAPK] in rat pulmonary microvascular endothelial cells . Positive_regulation MAPK7 TNF 21422246 2416773 Interestingly , all PHA-L ( high ) DCs displayed a strongly reduced responsiveness to induced [p38-MAPK] *activation* compared with PHA-L ( low ) DCs , indicating differences in PHA-L binding capacities between DCs with different inflammatory properties . Positive_regulation MAPK7 TNF 21422246 2416787 Moreover , hybrid-type , but not complex-type , N-glycans are required for *induced* [p38-MAPK] activation and subsequent phenotypic maturation of BMDCs ( MHC-II , CD86 , CCR7 upregulation ) . Positive_regulation MAPK7 TNF 21520062 2423126 Here , we report that *induced* cPLA(2) protein and mRNA expression , PGE ( 2 ) production , and phosphorylation of p42/p44 MAPK , p38 [MAPK] , and JNK1/2 , which were attenuated by pretreatment with a ROS scavenger [ N-acetyl-L-cysteine , ( NAC ) ] and the inhibitors of NADPH oxidase [ apocynin (APO) and diphenyleneiodonium chloride ( DPI ) ] , MEK1/2 ( U0126 ) , p38 MAPK ( SB202190 ) , and JNK1/2 ( SP600125 ) or transfection with siRNA of Nox2 , p47(phox) , MEK1 , p42 , p38 , or JNK2 . Positive_regulation MAPK7 TNF 21545687 2554385 significantly *induced* phosphorylation of p38 [MAPK] , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation MAPK7 TNF 21894146 2510885 Vehicle and untreated NTN exhibited heavy proteinuria and glomerular thrombosis at 24 h with P-selectin and fibrin immunostaining within capillaries , glomerular macrophage and T cell infiltration , *activation* of JNK and p38 [MAPK] signalling , and upregulation of glomerular mRNA levels of pro-inflammatory molecules ( , NOS2 , MMP-12 and CCL2 ) . Positive_regulation MAPK7 TNF 22002864 2526332 These results suggest that H ( 2 ) O ( 2 ) -induced secretion of *increases* apoptosis of cardiac myocytes through ROS dependent activation of p38 [MAPK] . Positive_regulation MAPK7 TNF 22227193 2544581 Casuarinin significantly inhibited *induced* activation of NF-?B , STAT1 , and p38 [MAPK] . Positive_regulation MAPK7 TNF 22230399 2519481 KMUP-1 inhibited *induced* iNOS and U46619 induced PDE-5A and phospho-p38 [MAPK] in normoxia , confirming its anti-proinflammatory action . Positive_regulation MAPK7 TNF 22250084 2551216 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Positive_regulation MAPK7 TNF 22343222 2617829 Using immunohistological techniques , we showed a higher epithelial expression of , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator [protein-1/mitogen activated protein kinase] signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation MAPK7 TNF 22525504 2522577 *up-regulated* the phosphorylation levels of p38 [MAPK] and increased the translocation of NF-kB p65 protein into the nucleus , also proved by immunofluorescence staining . Positive_regulation MAPK7 TNF 22526394 2595918 also *increased* the production of inducible nitric oxide synthase (iNOS) , nitric oxide ( NO ) , and intercellular adhesion molecule 1 ( ICAM-1 ) through activation of p38 [mitogen activated protein kinase (MAPK)] from HT-29 cells . Positive_regulation MAPK7 TNF 22773691 2659907 induced *activation* of p38 [MAPK] and NF-?B was attenuated by miR-140-3p mimic . Positive_regulation MAPK7 TNF 22819264 2646100 CORM-2 inhibited *induced* activation of p38 [MAPK] , ERK1/2 , JNK , and NF-?B signaling pathways in HUVECs . Positive_regulation MAPK7 TNF 22947346 2678666 *induced* phosphorylated p38 [mitogen activated protein kinase] levels were increased in ASMCs from patients with severe asthma compared with those from patients with nonsevere asthma and nonasthmatic subjects , whereas TNF-a induced phosphorylated c-Jun N-terminal kinase and phosphorylated extracellular signal related kinase levels were increased in all asthmatic groups . Positive_regulation MAPK7 TNF 22988345 2674360 The EGF receptor and HER2 participate in *dependent* [MAPK] activation and IL-8 secretion in intestinal epithelial cells . Positive_regulation MAPK7 TNF 22988345 2674388 As the epidermal growth factor receptor (EGFR) is a known transducer of proliferative signals and a potent activator of MAPKs , we hypothesized that the EGFR participates in *dependent* [MAPK] activation and IL-8 secretion by intestinal epithelial cells ( IECs ) . Positive_regulation MAPK7 TNF 23071098 2720915 Mixed-effects modeling analysis of our data was vital for ascertaining that IL-1a and TGF-a treatment increased the activities of more pathways than IL-6 and TNF-a and that TGF-a and *increased* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phospho-protein levels in a synergistic manner . Positive_regulation MAPK7 TNF 23142559 2722791 Western blot analysis revealed that pilocarpine and physostigmine enhanced the *induced* phosphorylation of ERK1/2 and p38 [MAPK] and the degradation of I?Ba . Positive_regulation MAPK7 TNF 23333920 2758389 Interestingly , IL-27 promoted the basal and enhanced *induced* phosphorylation of p38 [MAPK] and Akt , but not I?Ba . Positive_regulation MAPK7 TNF 23353699 2754245 We further demonstrated that markedly *stimulated* p38 MAPK , p42/p44 [MAPK] , and JNK1/2 phosphorylation via a c-Src/EGFR , PDGFR/PI3K/Akt pathway . Positive_regulation MAPK7 TNF 23354775 2770583 p38a [mitogen activated protein kinases (MAPK)] may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , , interleukin-1ß , and oxidative stress . Positive_regulation MAPK7 TNF 23608189 2795248 Taken together , statins , via [ERK5] activation , suppress *stimulated* Rac-1 activation , ROS generation , NF-?B activation and VCAM-1 and ICAM-1 expression in human ECs , which provides a novel explanation for the pleiotropic effects of statins that benefit the cardiovascular system . Positive_regulation MAPK7 TNF 23664593 2838388 sFGL2 secretion by CD4 ( + ) T cells can be *induced* with and IFN-? stimulation through [MAPK] signaling in renal allograft AR . Positive_regulation MAPK7 TNF 23861542 2817257 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Positive_regulation MAPK7 TNF 23884101 2821473 Furthermore , P. vulgaris extract suppressed *induced* phosphorylation of p38 [mitogen activated protein kinase (MAPK)] and extracellular signal regulated kinase ( ERK ) . Positive_regulation MAPK7 TNF 23935096 2840775 In contrast , loss of SK1 prevented *induced* phosphorylation of p38 [MAPK] , and inhibition of p38 MAPK , like SK1 knockdown , also potentiates RANTES induction . Positive_regulation MAPK7 TNF 24069158 2846998 We showed that markedly *stimulated* p42/p44 [MAPK] , p38 MAPK , and JNK1/2 phosphorylation which were attenuated by their respective inhibitors . Positive_regulation MAPK7 TNF 24080497 2902544 Consistently , DUSP1 promotes apoptosis and decreases NF-?B activity in cells in which p38 [MAPK] is *induced* by treatment . Positive_regulation MAPK7 TNF 24089494 2848155 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed receptor 1 and *requires* activation of p38 [MAPK] , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation MAPK7 TNF 24361597 2911250 We further demonstrated that *stimulated* ERK1/2 , p38 [MAPK] , and JNK1/2 phosphorylation via a c-Src dependent PDGFR/PI3K/Akt pathway . Positive_regulation MAPK7 TNF 24378531 2911778 TRAF2 has been previously reported to be required for induced *activation* of p38 [MAPK] . Positive_regulation MAPK7 TNF 24441870 2922938 We showed that markedly *stimulated* Jak2 , PDGFR , Akt , and p42/p44 [MAPK] phosphorylation , which were attenuated by their respective inhibitors . Positive_regulation MAPK7 TNF 24441870 2922956 In addition , *induced* p42/p44 [MAPK] phosphorylation was reduced by AG1296 or LY294002 . Positive_regulation MAPK7 TNF 24441870 2922992 On the other hand , could *induce* Akt and p42/p44 [MAPK] translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation MAPK7 TNF 24446489 2912943 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Positive_regulation MAPK7 TNF 24489443 2884797 Finally , by investigating the intracellular pathways involved in promoting the VEC release of cytokines/chemokines , which are targeted by natural anti-inflammatory compounds , we documented that aLipoic acid significantly counteracted *induced* NF-?B and [p38/MAPK] activation while the effects of Ginkgo biloba appeared to be predominantly mediated by Akt . Positive_regulation MAPK7 TNF 24750790 2936584 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas and NO production *required* all three [MAPK] . Positive_regulation MAPK7 TNF 7689564 225769 *induced* activation and increased tyrosine phosphorylation of [mitogen activated protein (MAP) kinase] in human fibroblasts . Positive_regulation MAPK7 TNF 7689564 225782 induced *activation* of [MAPK] was demonstrated by its enhanced ability to phosphorylate myelin basic protein in vitro and by a characteristic shift in the electrophoretic mobility of MAPK proteins . Positive_regulation MAPK7 TNF 7722327 301762 *induces* tyrosine phosphorylation of [mitogen activated protein kinase] in adherent human neutrophils . Positive_regulation MAPK7 TNF 7722327 301788 PMN pretreatment with genistein , a tyrosine kinase inhibitor , inhibited the *induced* increase in tyrosine phosphorylation and [MAPK] activity . Positive_regulation MAPK7 TNF 8626494 360281 Inhibition of induced p42/p44 [mitogen activated protein kinase] *activation* by sodium salicylate . Positive_regulation MAPK7 TNF 8626494 360295 *activates* both p42 and p44 [mitogen activated protein kinases (MAPK)] in human FS-4 fibroblasts , cells for which TNF is mitogenic . Positive_regulation MAPK7 TNF 8626494 360308 We now show that *activates* p42 [MAPK] in two cell lines whose growth is inhibited by TNF . Positive_regulation MAPK7 TNF 8626494 360323 We now show that neither phorbol ester-sensitive protein kinase C nor Gialpha link TNF to p42/p44 MAPK activation , because pretreatment of FS-4 cells with phorbol ester to down-regulate protein kinase C or pretreatment with pertussis toxin to block Gialpha does not inhibit p42/p44 [MAPK] *activation* by . Positive_regulation MAPK7 TNF 8626494 360350 To further analyze MAPK activation in FS-4 cells , we compared p42/p44 [MAPK] *activation* by and epidermal growth factor (EGF) . Positive_regulation MAPK7 TNF 8626494 360368 Elucidation of the mechanism whereby sodium salicylate blocks *induced* p42/p44 [MAPK] activation may help to clarify TNF activated signaling pathways . Positive_regulation MAPK7 TNF 8662702 367187 additionally *caused* rapid p38 and JNK-1 [mitogen activated protein kinase] activation and efficient NF-kappaB translocation , which could not be achieved even by high levels of ceramide . Positive_regulation MAPK7 TNF 8663194 368413 Angiotensin II , phorbol ester , platelet derived growth factor , and were the strongest stimuli for ERK1/2 but were weak *activators* of [BMK1] . Positive_regulation MAPK7 TNF 9106254 424423 The increases in [MAPK] *induced* by and IL-1 were similar to the increases induced by PMA and PDGF-AB . Positive_regulation MAPK7 TNF 9106254 424449 Our findings indicate that and IL-1 activate parallel signal transduction pathways in human neuroma fibroblasts , and that they are relatively stronger *activators* of [MAPK] than of SAPK . Positive_regulation MAPK7 TNF 9315666 456105 , an inhibitor of insulin stimulated adipogenesis , *activated* [MAPK] in 3T3-L1 cells . Positive_regulation MAPK7 TNF 9439626 482874 *increased* ERK1 and ERK2 [MAPK] phosphorylation . Positive_regulation MAPK7 TNF 9439626 482900 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic effect of *requires* protein tyrosine phosphorylation and [MAPK] activation . Positive_regulation MAPK7 TNF 9593119 505490 The CAZ released endotoxin was similar to purified LPS with respect to the following biological activities in LPS-responsive C3H/HeN mice and LPS-hyporesponsive C3H/HeJ mice : lethal toxicity in GalN sensitized mice , in vitro induction of and NO production by macrophages , and [mitogen activated protein kinase] *activation* in macrophages . Positive_regulation MAPK7 TNF 9766635 538518 Our data suggest that and GM-CSF *activate* ERKs and p38 [MAPK] by different signal transduction pathways . Positive_regulation MAPK7 TNF 9770326 538807 Furthermore , *induction* of p42/p44 ERK and [p38-MAPK] phosphorylation , c-jun kinase activation , and IkappaBalpha degradation were normal . Positive_regulation MAPK7 TNF 9883899 558213 *Activation* of p42/p44 mitogen activated protein kinases (MAPK) and p38 [MAPK] by is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation MAPK7 TNF 9883899 558228 Here , we demonstrate that is *sufficient* to activate p42/p44 MAPK and p38 [MAPK] . Positive_regulation MAPK7 TNF 9930718 588842 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Positive_regulation MAPK7 TNF 9931102 588909 ( 100 U/mL ) transiently *activated* [MAPK] with a maximal induction 10 minutes after stimulation that returned to baseline levels by 2 hours after treatment . Positive_regulation MAPK7 TNF 9931102 588922 PD98059 also blocked *stimulated* [MAPK] activation in a concentration dependent manner , which is consistent with its inhibition of TNF-alpha directed migration . Positive_regulation MAPK7 TNF 9931102 588935 To identify which TNF-alpha receptor is involved in *induced* [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Positive_regulation MAPK7 TNF 9931102 588961 VSMC express both receptors , but induced [MAPK] *activation* was inhibited only by the TNF-R1 antibody . Positive_regulation MAPK7 TNF 9931102 588987 Both TRO and RSG inhibited migration , but neither attenuated *induced* [MAPK] activation , indicating that their antimigration activity was exerted downstream of MAPK . Positive_regulation MAPK7 TNFSF10 12969966 1185576 Among the intracellular pathways investigated , significantly *stimulated* the extracellular signal regulated kinase 1/2 ( ERK1/2 ) but not the [p38/mitogen activated protein kinase (MAPK)] or the c-Jun NH2-terminal kinase (JNK) pathway . Positive_regulation MAPK7 TNFSF10 20951126 2364972 Taken together , this study provided first evidence demonstrating that , TNF-a- , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK7 TNFSF10 21152872 2373398 Taken together , we show herein that the upstream molecule of the induced [MAPK] *activation* is MEKK , as opposed to ASK1 , via the mediation of its signal through JNK/p38 in a caspase-8 dependent manner . Positive_regulation MAPK7 WNT7A 16835228 1606476 and Fzd 9 expression *resulted* in activation of [ERK5] , which was required for PPARgamma activation in NSCLC . Positive_regulation MAPK8 ADRB2 11018034 752795 *induced* p38 [MAPK] activation is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes . Positive_regulation MAPK8 ADRB2 12509508 1038752 beta-Arrestin 1 is required for internalization and [mitogen activated protein (MAP) kinase] *activation* by the . Positive_regulation MAPK8 ADRB2 19047375 2023489 Hematopoietic protein tyrosine phosphatase mediates *induced* regulation of p38 [mitogen activated protein kinase] in B lymphocytes . Positive_regulation MAPK8 ADRB2 9038193 415370 In the present work , we report that stimulation of the A2A-adenosine receptor and of the *activates* [mitogen activated protein kinase] ( MAP kinase ) in human endothelial cells based on the following criteria : adenosine analogues and beta-adrenergic agonists cause an ( i ) increase in tyrosine phosphorylation of the p42 isoform and to a lesser extent of the p44 isoform of MAP kinase and ( ii ) stimulate the phosphorylation of myelin basic protein by MAP kinase; (iii) this is accompanied by a redistribution of the enzyme to the perinuclear region . Positive_regulation MAPK8 ADRB2 9363896 462913 We show that in HEK293 cells , *stimulation* of [mitogen activated protein (MAP) kinase] by the is mediated by the betagamma subunits of pertussis-toxin-sensitive G proteins through a pathway involving the non-receptor tyrosine kinase c-Src and the G protein Ras . Positive_regulation MAPK8 ALOX5 11807011 903513 In contrast , stress induced product formation and translocation of <5-LO> , as well as *activation* of p38 [MAPK] , occurred also after Ca ( ++ ) depletion . Positive_regulation MAPK8 ALOX5 21200133 2391698 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Positive_regulation MAPK8 ANGPT1 12039842 954286 Accordingly , ephrinB2 inhibited VEGF- and *induced* [Ras-MAPK] activities , whereas ephrinB2 did not alter VEGF induced Flk phosphorylation or Ang1 induced Tie2 phosphorylation . Positive_regulation MAPK8 ANGPT1 12213710 985653 Both VEGF and *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 [MAPK] . Positive_regulation MAPK8 ANGPT1 12213726 985723 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of and Ang-2 as well as the *activation* of [MAPK] , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation MAPK8 ANGPT1 16061664 1439074 *activated* [mitogen activated protein kinase (MAPK)] and phosphoinositide 3-kinase (PI3K) in IBE cells and HUVECs . Positive_regulation MAPK8 ANGPT1 16679392 1612158 Pretreatment with either DPI or apocynin also significantly attenuated *induced* Akt and p44/42 [MAPK] phosphorylation . Positive_regulation MAPK8 ANGPT1 16679392 1612174 Using mouse heart microvascular endothelial cells from wild-type ( WT ) mice and mice deficient in the p47(phox) component of NADPH oxidase ( p47 ( phox-/- ) ) , we found that although *stimulated* intracellular ROS , Akt and p42/44 [MAPK] phosphorylation , and cell migration in WT cells , the responses were strikingly suppressed in cells from the p47 ( phox-/- ) mice . Positive_regulation MAPK8 ANGPT1 20072135 2235292 *promoted* skin cell metabolism/viability , adhesion , and akt and [MAPK] ( p42/44 ) activations . Positive_regulation MAPK8 ANO1 22564524 2619167 *induces* [MAPK] and contributes directly to tumorigenesis and cancer progression . Positive_regulation MAPK8 CAPN8 21543591 2424187 Downstream , an Aß-mediated rise in p38 [mitogen activated protein kinase (MAPK)] activation was followed by downregulation of cAMP response element binding protein , and LTP impairment was *prevented* by inhibitors of p38 MAPK or . Positive_regulation MAPK8 CAPN8 24416390 2901055 Treatment with glutamate leads to early activation of NMDAR , which in turn leads to mediated cleavage of striatal enriched protein tyrosine phosphatase ( STEP ) and subsequent *activation* of p38 [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK8 CCL17 23711854 2792912 IL-33 induced the production of thymus and activation regulated and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 [MAPK] . Positive_regulation MAPK8 CCND1 11004713 735026 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping [ERK-MAPK] activation and c-Fos and *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation MAPK8 CCND1 12654183 1072989 [MAPK] may *induce* overexpression of protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation MAPK8 CCND1 15634644 1349559 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 [mitogen activated protein kinase] , and down-regulation of . Positive_regulation MAPK8 CCND1 16522728 1531463 We conclude that incretin induced beta-cell replication is dependent on cAMP/PKA , p42 [MAPK] and PI3K activities , which may *involve* transcriptional induction of . Positive_regulation MAPK8 CCND1 17055752 1683909 The data showed overexpression of and increased expression and *activation* of ERK1/2 , p38 kinase and [JNK1/2] with progression of tumor suggesting that MAP kinases play an important role during tumorigenesis . Positive_regulation MAPK8 CCND1 9537433 497570 Furthermore , in 25 of 26 cases of HCC which genomic DNA was available , 22 cases without genomic DNA amplification exhibited positive correlation , not only between protein expression of c-Fos and , but also between [MAPK/ERK] *activation* and cyclin D1 expression . Positive_regulation MAPK8 CD14 15625444 1349242 LPS interacts with the cell surface receptor , which generates transmembrane signals through Toll-like protein 4 *leading* to [mitogen activated protein kinase (MAPK)] p38 activation , cytokine synthesis , PMN beta2-integrin expression and oxidative burst . Positive_regulation MAPK8 CHI3L1 23755018 2797733 In addition , *induces* [FAK-MAPK] signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation MAPK8 CHI3L1 23972995 2836245 We also demonstrate that *activates* macrophage [mitogen activated protein kinase] , protein kinase B/AKT , and Wnt/ß-catenin signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation MAPK8 CLU 23051594 2702830 FOXL2 directly stimulates the Clu gene promoter , and we show that PTTG triggers ataxia telangiectasia mutated [kinase/IGF-I/p38MAPK] DNA damage/chromosomal instability signaling , which in turn also *induces* expression . Positive_regulation MAPK8 CTGF 11732999 885268 *induces* chondrocyte differentiation through a p38 [mitogen activated protein kinase] ( p38MAPK ) , and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase ( ERK ) . Positive_regulation MAPK8 CTGF 11732999 885282 In the proliferation phase , *induced* a approximately fivefold increase in the phosphorylation of p44/42 [MAPK/ERK] and a approximately twofold increase in that of p38 MAPK in an in vivo kinase assay . Positive_regulation MAPK8 CTGF 12218048 1012168 The inhibition of *induced* p42/44 [MAPK] or phosphatidylinositol 3-kinase (PI3K)/protein kinase B pathway activities abrogated the induction of fibronectin expression . Positive_regulation MAPK8 CTGF 16408113 1513483 *enhanced* the mRNA expression and protein release of fractalkine , MCP-1 , and RANTES , the expression of phospho ( P ) -p42/44 [mitogen activated protein kinase (MAPK)] , P-phosphoinositide 3-kinase (PI3-K) , P-Akt , and activity of nuclear factor-kappaB (NF-kappaB) in mesangial cells . Positive_regulation MAPK8 CTGF 16408113 1513523 P-p42/44 MAPK blockade inhibited the *induced* expression of P-p42/44 [MAPK] but not NF-kappaB , and partially decreased the levels of the above chemokines in supernatants . Positive_regulation MAPK8 CTGF 16522717 1531331 ( 3 ) *stimulated* dose dependent HSC adhesion and activity of p42/p44 [mitogen activated protein kinase] , the latter of which was antagonized by blocking the activity of focal adhesion kinase . Positive_regulation MAPK8 CTGF 16938382 1654130 No single module , but a mixture of the 4 modules provoked a significant activation of p38 [MAPK] in HCS-2/8 cells , which was *activated* by the full-length . Positive_regulation MAPK8 CTGF 19038999 2023095 Interestingly , CCN2-BMP-2 did not affect the *induced* phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Positive_regulation MAPK8 EDN2 12193071 980949 The molecular mechanisms of dependent *activation* of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Positive_regulation MAPK8 EDN2 12475899 1037787 *induced* a rapid phosphorylation of the [mitogen activated protein kinase (MAPK)/ERK] and increased collagen I gene activity in freshly isolated aortas . Positive_regulation MAPK8 EDN2 1280103 203054 rapidly *stimulates* [mitogen activated protein kinase] activity in rat mesangial cells . Positive_regulation MAPK8 EDN2 12855582 1149905 also *induced* the activation of p42/44 [mitogen activated protein kinase (MAPK)] in DCs . Positive_regulation MAPK8 EDN2 7509933 241621 *stimulates* [mitogen activated protein kinase] p42 activity through the phosphorylation of the kinase in rat mesangial cells . Positive_regulation MAPK8 EDN2 7849246 286745 *stimulates* [mitogen activated protein kinase] activity in mesangial cells through ETA . Positive_regulation MAPK8 EDN2 7943276 276412 has been shown to *activate* [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK8 EDN2 8836145 386186 In bovine airway smooth-muscle cells platelet derived growth factor ( PDGF ) and ( Et-1 ) *stimulate* sustained and comparable activation of [mitogen activated protein kinase] ( MAP kinase ) but display very different mitogenic efficacies , with PDGF inducing 50 times more DNA synthesis than Et-1 . Positive_regulation MAPK8 EFNB1 15502157 1347566 Further downstream of the signaling pathway , stimulation *led* to increased LAT ( linker for activation of T-cells ) phosphorylation and p44/42 and p38 [MAPK] activation . Positive_regulation MAPK8 EPHB2 10601128 574222 Tumor necrosis factor-alpha (TNF-alpha) alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only . Positive_regulation MAPK8 EPHB2 10872747 707031 Pre-treatment of the cells with PD98059 , a selective pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation MAPK8 EPHB2 11083274 750497 Tumor necrosis factor alpha , interleukin-1 (IL-1) , and IL-6 were the major inducers of , JNK , and p38 [MAPK] *activation* in cultured human synovial cells . Positive_regulation MAPK8 EPHB2 12386816 999769 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 [MAPK] and a biphasic *activation* of . Positive_regulation MAPK8 EPHB2 12403788 1036191 SB203580 , a p38 [MAPK] *inhibitor* , and PD98059 , an inhibitor , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation MAPK8 EPHB2 12486127 1056314 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain *had* little effect on basal Erk [MAPK] activation . Positive_regulation MAPK8 EPHB2 12511425 1070743 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation MAPK8 EPHB2 12801927 1120238 GE2 stimulation *induced* phosphorylation , whereas it did not alter the phosphorylation of c-Jun N-terminal kinase or p38 [MAPK] . Positive_regulation MAPK8 EPHB2 12832293 1105583 Exposure to E. coli DNA resulted in phosphorylation of ERK 1/2 [MAPK] and inhibitors of activity ( PD98059 , UO126 ) significantly *reduced* the evoked IL-8 production . Positive_regulation MAPK8 EPHB2 12878192 1115525 ( 2 ) the *activation* of JNK and p38 [MAPK] but not in embryonic fibroblasts ( MEFs ) derived from ASK1 knockout mice ( ASK1 ( -/- ) MEFs ) was depressed compared to MEFs derived from wild type mice ( ASK1 ( +/+ ) MEFs ) ; Positive_regulation MAPK8 EPHB2 14973553 1212774 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen activated protein kinase (MAPK)] signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation MAPK8 EPHB2 14998726 1216736 Furthermore , we found that PD98059 , an pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation MAPK8 EPHB2 15659876 1350319 The anabolic effect of TNF-alpha was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an . Positive_regulation MAPK8 EPHB2 16038626 1437439 SF significantly prevented Abeta induced increases in IL-1beta and p38 [MAPK] *activation* and also Abeta induced changes in and phospho-Akt/PKB expression levels . Positive_regulation MAPK8 EPHB2 17056059 1649533 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Positive_regulation MAPK8 EPHB2 17403539 1735940 Trauma-hemorrhage increased the production of IL-6 , IL-10 , IL-12 and TNF-alpha enhanced the expression of TLR4 , MyD88 as well as the *activation* of [MAPK] proteins ( p38 , and JNK ) in epidermal keratinocytes . Positive_regulation MAPK8 EPHB2 17416211 1777927 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK8 EPHB2 17464174 1731751 The mRNA and surface protein up-regulation of CCR1 and CCR2 in 9CRA stimulated cells were weakly blocked by the pretreatment of SB202190 , a p38 [MAPK] *inhibitor* , and PD98059 , an upstream inhibitor . Positive_regulation MAPK8 EPHB2 18164124 1869616 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 [MAPK] , but not by the *activation* of JNK , , and NF-kappaB pathway . Positive_regulation MAPK8 EPHB2 18266967 2000324 VEGF induced activation of p42 also *led* to the nuclear translocation of [MAPK/ERK1/2] . Positive_regulation MAPK8 EPHB2 18285354 1885412 Pre-treatment with the [MAPK] *inhibitors* SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( inhibitor ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation MAPK8 EPHB2 18338254 1938064 Interestingly , inhibition of by U0126 completely *prevented* artepillin C-induced p38 [MAPK] phosphorylation of PC12m3 cells . Positive_regulation MAPK8 EPHB2 18520049 1918679 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of , rather than by the *activation* of p38 [MAPK] , in the spinal cord . Positive_regulation MAPK8 EPHB2 18982426 2105753 These inhibitory effects were partially inhibited by SB203580 , a specific *inhibitor* of p38 [MAPK] , but not by PD98059 , a specific inhibitors of extracellular signal regulated kinase ( ) , and SP600125 , a specific inhibitor of c-Jun-N-terminal kinase (JNK) . Positive_regulation MAPK8 EPHB2 19189219 2113968 Moreover , EM1 treatment resulted in less activation of p38 [MAPK] and more *activation* of signaling in lipopolysaccharide stimulated DCs . Positive_regulation MAPK8 EPHB2 19276187 2051424 Treatment of cells with sphingosine induced suppression of and *activation* of p38 [MAPK] . Positive_regulation MAPK8 EPHB2 19429670 2106927 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either inhibitor , [p38MAPK] *inhibitor* or NF-kappaB inhibitor . Positive_regulation MAPK8 EPHB2 19522739 2103147 Treatment with [MAPK] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation MAPK8 EPHB2 19672126 2168079 A scratch wound assay of healing rates in SV40 immortalized human corneal epithelial cell line ( HCEC ) evaluated the relative contributions by p38 and and JNK [MAPK] signaling *activation* to wound healing . Positive_regulation MAPK8 EPHB2 20025124 2175519 Prior treatment of the cells with PD98059 , an kinase inhibitor or SB203580 , a [p38MAPK] *inhibitor* , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation MAPK8 EPHB2 20554538 2327628 The HNE enhanced Sp1 and NF-?B activities were attenuated by SB203580 , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , and PD98059 , an extracellular signal regulated kinase ( ) inhibitor , respectively . Positive_regulation MAPK8 EPHB2 21126656 2355805 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 [mitogen activated protein kinase] , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by . Positive_regulation MAPK8 EPHB2 21311676 2360040 Treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation MAPK8 EPHB2 21488184 2417979 Dexmedetomidine induced phosphorylation of JNK and p38 [MAPK] in rat aortic SMCs , but did not *induce* phosphorylation of . Positive_regulation MAPK8 EPHB2 21586573 2449672 Incubation of T cells with ESAT-6 induced phosphorylation and increased functional p38 [MAPK] activity , but not *activation* of or JNK . Positive_regulation MAPK8 EPHB2 21599960 2445738 In the present studies , induction of central sensitization as indicated by spinal dorsal horn [MAPK] *activation* , specifically and p38 phosphorylation , was assessed in the MIA-OA model . Positive_regulation MAPK8 EPHB2 23394443 2713248 When compared to hamsters bearing tumors that remained on the control diet , the buccal pouches of hamsters bearing tumors receiving turmeric showed the following results : ( 1 ) decreased cell proliferation ( diminished PCNA , cyclin D1 , and Bcl-2 ) and PCNA labelling index , ( 2 ) enhanced apoptosis ( increased Bax , caspase-3 , caspase-9 , and cytochrome c , and decreased survivin ) and apoptotic index , ( 3 ) decreased inflammation ( decreased Cox-2 ) , and ( 4 ) decreased [MAPK] *activation* ( and p-p38 ) . Positive_regulation MAPK8 EPHB2 23892041 2830341 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three [MAPK] *inhibitors* ( inhibitor PD98059 , JNK inhibitor SP600125 and p38 inhibitor SB203580 ) . Positive_regulation MAPK8 EPHB2 23914844 2840577 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 [MAPK] and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of , JNK , NF-?B . Positive_regulation MAPK8 EPHB2 23917355 2826051 Inhibition of Akt or activity *reduced* phosphorylation of STAT1 in Colon26L5-CUG2 cells whereas inhibition of p38 [MAPK] did not significantly decrease levels of STAT1 phosphorylation , indicating that cell proliferation signals may be involved in CUG2 mediated activation of STAT1 . Positive_regulation MAPK8 EPHB2 24225419 2897501 Therefore , by using the [MAPK] *inhibitors* SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific inhibitor ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation MAPK8 EPHB2 24297112 2894231 Following treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation MAPK8 F2R 16052512 1460031 The p38 and ERK1/2 [MAPK] signaling cascades were also *activated* by stimulation , whereas the SAPK/JNK pathway was unaffected . Positive_regulation MAPK8 F2R 16467309 1548165 and PAR-2 stimulation rapidly *activated* both ERK1/2 and [p38MAPK] , and pharmacological blockade of MEK with either PD98059 or U0126 or of p38MAPK by SB203580 or SB202190 strongly inhibited thrombin- and SLIGKV induced COX-2 expression and 6-keto-PGF1alpha formation . Positive_regulation MAPK8 F2R 21252088 2402891 In the present study , we show that FVIIa , upon binding to EPCR on endothelial cells , activates endogenous protease activated receptor-1 (PAR1) and induces mediated p44/42 [mitogen activated protein kinase (MAPK)] *activation* . Positive_regulation MAPK8 F2R 24052258 2867022 However , the distinct non-canonical tethered ligands unmasked by neutrophil elastase and proteinase-3 , as well as synthetic peptides with sequences derived from these novel exposed tethered ligands , selectively stimulated mediated [mitogen activated protein kinase] *activation* . Positive_regulation MAPK8 F2R 8635212 358007 These results support the notion that the *activates* [MAPK] through PKC dependent pathways and that the incremental activation of MAPK by TRAP over that induced by thrombin is the consequence of enhanced activation through the PKC limb of the phosphoinositide lipid pathway . Positive_regulation MAPK8 FAS 14576831 1156611 A more physiological inhibitor , the intracellular PP2A inhibitor protein I2 ( PP2A ) , protected transfected HeLa cells in a similar way from *mediated* apoptosis and induced activation of [MAPK] in I2 ( PP2A ) transfected cells . Positive_regulation MAPK8 FAS 15280387 1302538 We further demonstrate that this pro-apoptotic effect of CO was independent of reactive oxygen species production and involved inhibition in induced *activation* of the pro-survival ERK [MAPK] . Positive_regulation MAPK8 FAS 16507991 1529647 Here we show that binding of Fas ligand to *activates* p38 [MAPK] in CD8+ T cells and that activation of this pathway is required for Fas mediated CD8+ T-cell death . Positive_regulation MAPK8 FAS 19417161 2179816 GST-MDA-7 killing was , in parallel , dependent on inactivation of extracellular signal regulated kinase 1/2 and on *induced* p38 [mitogen activated protein kinase] and c-jun NH ( 2 ) -terminal kinase-1/2 signaling . Positive_regulation MAPK8 FAS 21613257 2454282 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Positive_regulation MAPK8 FAS 21975294 2492849 Caspase-8 activity has an essential role in *mediated* [MAPK] activation . Positive_regulation MAPK8 FAS 8977313 403352 IFN-alpha2 did not alter the *induced* activity of [Mitogen activated protein kinase (MAPK)] 1 and did not inhibit the Apo-1/Fas mediated proteolytic cleavage of ADP-ribosyltransferase , a substrate of Interleukin-beta1 converting enzyme ( ICE ) and homologues . Positive_regulation MAPK8 FHL1 23456229 2781823 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Positive_regulation MAPK8 FOXA1 22879989 2641688 An increase in IGFBP-3 , mediated by depletion of , *inhibited* phosphorylation of [MAPK] and Akt , and increased expression of the cell cycle regulators p21 and p27 . Positive_regulation MAPK8 FUT4 20506505 2307961 These data suggested that not only *activates* [MAPK] and PI3K/Akt signals , but also promotes the crosstalk among these signaling pathways . Positive_regulation MAPK8 GLP1R 21356521 2394821 activation by Exendin-4 ( Ex-4 ) *increased* PKA and [MAPK] activity and decreased phosphorylation of AMPK in NTS . Positive_regulation MAPK8 GPR115 10958680 725981 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK8 GPR115 11916960 945733 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK8 GPR115 9182581 435927 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on mediated *activation* of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK8 GPR115 9826186 550324 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK8 GPR132 10958680 725970 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK8 GPR132 11474113 841744 Activation of by LPC *increased* intracellular calcium concentration , induced receptor internalization , activated ERK [mitogen activated protein kinase] , and modified migratory responses of Jurkat T lymphocytes . Positive_regulation MAPK8 GPR132 11916960 945722 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK8 GPR132 9182581 435916 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK8 GPR132 9826186 550313 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK8 GPR87 10958680 726050 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK8 GPR87 11916960 945802 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK8 GPR87 9182581 435996 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on *mediated* activation of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK8 GPR87 9826186 550393 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK8 HBEGF 10544013 563929 also rapidly *activated* [MAPK] and induced cyclin D1 in mid-G1 with kinetics similar to TGFalpha . Positive_regulation MAPK8 HBEGF 11171084 783800 Both p42 [MAPK] activation and mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation MAPK8 HBEGF 15380451 1298486 *induced* phosphorylation of ERK , p38 [MAPK] and Akt , which were suppressed by ZD1839 . Positive_regulation MAPK8 HBEGF 17928891 1858630 We report that cellular stress with methyl-beta-cyclodextrin ( MBCD ) , a molecule that extracts membrane cholesterol and thereby disrupts the structure of lipid rafts , strongly *induces* the synthesis of ( HB-EGF ) in keratinocytes through the activation of p38 [mitogen activated protein kinase] . Positive_regulation MAPK8 HBEGF 18990151 2028929 *Activation* of [Erk/MAPK] by was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation MAPK8 HBEGF 19048624 2023722 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked MAPK signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 [MAPK] , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Positive_regulation MAPK8 HBEGF 19559571 2110510 *induced* phosphorylation of p42/p44 [MAPK] in a few minutes . Positive_regulation MAPK8 HBEGF 20739666 2345895 Moreover , *induced* a stronger and more sustained activation of both the [mitogen activated protein kinase] and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation MAPK8 HBEGF 24188029 2921114 Here , we show that *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , [Mapk/Erk] pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation MAPK8 HRH1 11959800 931447 1. Previous studies have shown that the *activates* p42/p44 [mitogen activated protein kinases (MAPK)] in DDT ( 1 ) MF-2 smooth muscle cells via a phosphatidylinositol 3-kinase (PI-3K) dependent pathway . Positive_regulation MAPK8 HRH1 17965772 1820345 is *required* for TCR mediated p38 [MAPK] activation and optimal IFN-gamma production in mice . Positive_regulation MAPK8 HRH1 17965772 1820359 Moreover , signaling at the time of TCR ligation was *required* for activation of p38 [MAPK] , a known regulator of IFN-gamma expression . Positive_regulation MAPK8 IFI27 16953232 1682596 RET2A mediated regulation of p18 and , but not of cyclins D1 and D2 , *requires* functional [mitogen activated protein kinase] signaling . Positive_regulation MAPK8 IL1B 10640438 577516 and TNF alpha also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK8 IL1B 10704772 673011 CPI-1189 inhibits *induced* [p38-mitogen activated protein kinase] phosphorylation : an explanation for its neuroprotective properties ? Positive_regulation MAPK8 IL1B 10775561 686650 *activated* p44/42 [MAPK] , and this activation was enhanced in the presence of N-acetyl-L-cysteine . Positive_regulation MAPK8 IL1B 10864897 705738 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK8 IL1B 10864897 705790 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by TNF-alpha and . Positive_regulation MAPK8 IL1B 10864897 705804 TNF-alpha- and *induced* [ ( 3 ) H ] -thymidine incorporation and phosphorylation of p42/p44 [MAPK] was completely inhibited by PD98059 ( an inhibitor of MEK1/2 ) , indicating that activation of MEK1/2 was required for these responses . Positive_regulation MAPK8 IL1B 10969830 728492 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Positive_regulation MAPK8 IL1B 11032891 740460 *induces* p38 [MAPK] phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation MAPK8 IL1B 11037878 741247 also *stimulated* phosphorylation of p38 [MAPK] , SAPK/JNK , and ATF-2 . Positive_regulation MAPK8 IL1B 11126408 759779 TNFalpha and IFNgamma potentiate *induced* [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK8 IL1B 11126408 759792 [Mitogen activated protein kinase (MAPK)] activity that is *induced* by has been suggested to signal nitric oxide dependent as well as nitric oxide independent beta-cell destructive pathways . Positive_regulation MAPK8 IL1B 11126408 759805 The aim of this study was to investigate if TNFalpha and IFNgamma signal through mitogen activated protein kinases in isolated rat islets of Langerhans and if they potentiate [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK8 IL1B 11126408 759818 Further , TNFalpha and IFNgamma were found to synergistically increase [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK8 IL1B 11399523 824266 Glucose potentiates *induced* p38 [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK8 IL1B 11509550 848380 Although and TNF-alpha each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK8 IL1B 11557585 861409 *activated* the three [mitogen activated protein kinase] ( extracellular signal regulated kinases 1 and 2 , c-Jun NH2-terminal kinase/stress activated protein kinase , and p38 ) and the Janus kinase (JAK)-signal transducer and activator of transcription pathways . Positive_regulation MAPK8 IL1B 11698472 878058 *induced* phosphorylation and activation of p38 [MAPK] and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation MAPK8 IL1B 11698472 878104 *induced* phosphorylation of ERK and JNK as well as p38 [MAPK] in human endothelial cells . Positive_regulation MAPK8 IL1B 11728947 884815 We showed a dramatic decrease in *induced* phosphorylation of p38 [MAPK] , not extracellular signal regulated kinases 1/2 or jun NH2-terminal kinase , in rat cultured mesangial cells by FR167653 . Positive_regulation MAPK8 IL1B 11775830 766443 Role of protein tyrosine kinase in *induced* activation of [mitogen activated protein kinase] in fibroblast-like synoviocytes of rheumatoid arthritis . Positive_regulation MAPK8 IL1B 11853544 913377 Interestingly , *induced* p38 [MAPK] activity was greatly enhanced in ( alg+ ) compared with ( alg- ) cells . Positive_regulation MAPK8 IL1B 12117921 964671 mRNA expression by neutrophils was not dependent on p38 MAPK , and p38 [MAPK] was not *activated* in neutrophils incubated with A. phagocytophila . Positive_regulation MAPK8 IL1B 12131776 966871 and TNF-alpha *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK8 IL1B 12139924 969402 Regarding intracellular signaling , *activated* the p38 [mitogen activated protein kinase (MAPK)] but not the p42/p44 MAPK and , when combined with growth factors , intensified p38 activation but inhibited the growth-factor induced p42/p44 activation . Positive_regulation MAPK8 IL1B 12356282 993898 induced p44/42 [mitogen activated protein kinase (MAPK)] *activation* was inhibited by the MAPK/extracellular signal regulated protein kinase ( MEK ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK8 IL1B 12417253 1012959 Sphondin ( 50 microM ) did not affect the *induced* activations of p44/42 MAPK , p38 [MAPK] , and JNK . Positive_regulation MAPK8 IL1B 12500176 1026693 These data suggest that the presence of retinal holes and may *lead* to activation of HGF , [mitogen activated protein kinases (MAPK)] , c-jun and extracellular matrix remodeling , resulting in proliferative and migratory cells in the wounded retina . Positive_regulation MAPK8 IL1B 12507586 1038427 In this study we evaluated the role of epigallocatechin-3-gallate ( EGCG ) , a green tea polyphenol which mimics its anti-inflammatory effects , in modulating the *induced* activation of [MAPK] 's in human chondrocytes . Positive_regulation MAPK8 IL1B 12649265 1080073 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant MKK6 or p38beta2 MAPK inhibited induced p38 [MAPK] *activation* , COX-2 gene expression , and PGE2 release . Positive_regulation MAPK8 IL1B 12727980 1086563 P38 [MAPK] phosphorylation was *increased* by in nondecidualized ESC , whereas the IL-1 beta induced increase was suppressed in the decidualized cells . Positive_regulation MAPK8 IL1B 12727980 1086576 Treatment with 8-bromo-cAMP reduced *induced* phosphorylation of p38 [MAPK] in nondecidualized ESC . Positive_regulation MAPK8 IL1B 12727980 1086590 In contrast , treatment with H89 , a protein kinase A inhibitor , reversed a reduction in *induced* p38 [MAPK] phosphorylation in the decidualized cells . Positive_regulation MAPK8 IL1B 12727980 1086604 The altered property of decidualized cells is thought to be caused by attenuation of *induced* p38 [MAPK] phosphorylation in a way that involves the activation of the cAMP/protein kinase A pathway . Positive_regulation MAPK8 IL1B 12882449 1116295 NAC ( 1 mM ) also decreased the induced *activation* of p38 [MAPK] . Positive_regulation MAPK8 IL1B 12952251 1137423 Using Western-blot analysis , no effect of cAMP was found on the *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK8 IL1B 12952251 1137437 No decrease was observed in *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK8 IL1B 14563491 1154866 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Positive_regulation MAPK8 IL1B 15039421 1251247 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of , and RIP2 dependent *activation* of NF-kappaB and p38 [MAPK] mediated by the caspase recruitment domain . Positive_regulation MAPK8 IL1B 15111866 1241245 We further demonstrated that p38 MAPK is activated by and PDGF with different kinetics and that p38 [MAPK] is *required* for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation MAPK8 IL1B 15208668 1281349 *induced* the activation of extracellular signal regulated kinases-1/2 and P38 [mitogen activated protein kinase (MAPK)] , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation MAPK8 IL1B 15341531 1291767 In accordance with these findings , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) , which was attenuated by U0126 , SB202190 , or SP600125 , respectively . Positive_regulation MAPK8 IL1B 15389584 1354325 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] and JNK which was attenuated by pretreatment with U0126 or SP600125 , respectively . Positive_regulation MAPK8 IL1B 15489374 1359429 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and JNK was attenuated by pretreatment with U0126 , SB-202190 , or SP-600125 , respectively . Positive_regulation MAPK8 IL1B 15695308 1382611 A77 1726 inhibited *induced* p38 and [c-Jun N-terminal kinase 1/2] ( JNK1/2 ) activation , whereas A77 1726 did not affect IL-1beta induced NF-kappaB activation in hepatocytes . Positive_regulation MAPK8 IL1B 15755725 1403427 The inhibitory effect of on alpha ENaC expression was *mediated* by the activation of p38 [MAPK] in both rat and human ATII cells and was independent of the activation of alpha v beta6 integrin and transforming growth factor-beta . Positive_regulation MAPK8 IL1B 15831571 1417978 In insulin secreting rat INS-1 cells cultured in the presence of 11 mm glucose , combined pharmacological blockade of L- and T-type Ca ( 2+ ) channels suppressed IL-1beta induced in vitro phosphorylation of the JNK substrate c-jun and reduced *stimulated* activation of [JNK1/2] as assessed by immunoblotting . Positive_regulation MAPK8 IL1B 16033422 1436171 Intrathecal *leads* to a time dependent up-regulation of phosphorylated p38 ( p-p38 ) [MAPK] protein expression in the spinal cord 30-240 min following IL-1beta injection ( i.t. ) . Positive_regulation MAPK8 IL1B 16033422 1436185 However , pretreatment with a p38 MAPK inhibitor significantly reduced the *induced* p-p38 [MAPK] expression by 38-49 % , and nearly completely blocked the subsequent iNOS expression ( reduction by 86.6 % ) , NO production , and thermal hyperalgesia . Positive_regulation MAPK8 IL1B 16043966 1459747 Western blot analysis demonstrated that *increased* the activation of phosphorylated MEK and p38 [MAPK] in GH3 cells . Positive_regulation MAPK8 IL1B 16140882 1450811 *induced* phosphorylation of [p38-MAPK] , but not that of c-Jun-N-terminal kinase or extracellular regulated kinase , was most susceptible to inhibition by low doses of PFE , and the addition of PFE blocked the activity of p38-MAPK in a kinase activity assay . Positive_regulation MAPK8 IL1B 16141635 1454875 DHA stimulated both rapid and prolonged activation of p44/42 , but not p38 , [mitogen activated protein kinase (MAPK)] *induced* by and PMA . Positive_regulation MAPK8 IL1B 16153910 1455449 The kidney was analyzed for expression of tumor necrosis factor alpha , , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 [mitogen activated protein kinase] , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation MAPK8 IL1B 16452991 1611749 Western blots showed that and TNF-alpha *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK8 IL1B 16528573 1549434 The aim of this study was to investigate if Gadd45b prevents *induced* beta cell [MAPK] signalling and apoptosis . Positive_regulation MAPK8 IL1B 16645161 1604683 significantly *increased* the phosphorylation of p38 [MAPK] and cPLA(2) . Positive_regulation MAPK8 IL1B 16698013 1575660 JST ( 0.01-1 mg/ml ) also attenuated the expression of cyclooxygenase (COX)-2 and activation of p38 [MAPK] *induced* by and A beta ( 1-42 ) . Positive_regulation MAPK8 IL1B 16718462 1584915 A synthetic peptide , C3d , reported to bind NCAM , did not activate MAPK or Akt as reported in neurons but inhibited *induced* [MAPK] activity , thereby mimicking the effect of SU5402 . Positive_regulation MAPK8 IL1B 16718462 1584940 We suggest that NCAM signalling through FGFR is required for efficient IL-1beta pro-apoptotic signalling by facilitating *induced* [MAPK] activation downstream of the NF-kappaB-MAPK branching point . Positive_regulation MAPK8 IL1B 16718462 1584987 Further , these data identify a novel function of C3d as an inhibitor of NCAM induced FGFR activity and of induced [MAPK] *activation* in beta cells . Positive_regulation MAPK8 IL1B 16959849 1639704 *caused* an increase in the phosphorylation of ERK , but not [p38MAPK] or c-Jun N-terminal kinase . Positive_regulation MAPK8 IL1B 16964394 1611560 Inhibitors of p38 [MAPK] and/or JNK significantly suppressed VEGF secretion both in the *presence* and absence of , while inhibitors of COX-2 , ERK1/2 , and PI3-K did not . Positive_regulation MAPK8 IL1B 17208222 1695819 Thalidomide also suppressed induced p38 [mitogen activated protein kinase (MAPK)] *activation* , while a p38 MAPK inhibitor destabilized COX-2 mRNA and the cytoplasmic shuttling of HuR induced by IL-1beta . Positive_regulation MAPK8 IL1B 17311279 1719296 *stimulated* phosphorylation of p42/p44 MAPK , p38 [MAPK] , and JNK was attenuated by pretreatment with U0126 , SB202190 , SP600125 , or transfection with these dominant negative mutants of MEK , ERK , p38 and JNK , respectively . Positive_regulation MAPK8 IL1B 17390080 1716146 We have previously demonstrated that *induced* HBD-2 mRNA expression in A549 cells through activation of nuclear factor-kappaB (NF-kappaB) transcriptional factor as well as p38 [mitogen activated protein kinase (MAPK)] , c-Jun N-terminal kinase (JNK) , or phosphatidylinositol-3-kinase (PI3K) . Positive_regulation MAPK8 IL1B 17390080 1716168 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Positive_regulation MAPK8 IL1B 17390080 1716198 Triptolide inhibited *induced* [MAPK] phosphatase-1 expression at the transcriptional level and resulted in sustained phosphorylation of JNK or p38 MAPK , explaining the little effect of triptolide on IL-1beta induced phosphorylation of these kinases . Positive_regulation MAPK8 IL1B 17438131 1742786 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by TNF-alpha and , but not by ansiomycin or sorbitol . Positive_regulation MAPK8 IL1B 17559635 1753268 also *activated* extracellular signal regulated kinase , p38 [MAPK] , and c-Jun N-terminal kinase . Positive_regulation MAPK8 IL1B 17645739 1793276 Interestingly , Dex attenuated *mediated* activation of p38 [MAPK] and JNK , but not of AKT . Positive_regulation MAPK8 IL1B 17694686 1782119 IL-1beta induced NO levels and thermal hyperalgesia in rats , likely via either inhibiting the mediated p38 [MAPK] *activation* and subsequent iNOS induction , or direct attenuation of the central iNOS activity , which therefore reduces the central sensitization of inflammatory pain . Positive_regulation MAPK8 IL1B 17920534 1804196 SA981 at a concentration of 100 microM partially inhibited *induced* phosphorylation of [p38MAPK] and Akt ( 12.0 % and 36.1 % inhibition of each total amount of phosphoprotein under IL-1beta coexistence condition , respectively ) . Positive_regulation MAPK8 IL1B 17925024 1835160 *stimulated* phosphorylation of c-jun amino-terminal kinase , p38 [MAPK] and extracellular signal regulated kinase-1/2 . Positive_regulation MAPK8 IL1B 18026701 1827827 Moreover , glucosamine suppressed the *induced* phosphorylation of p38 [MAPK] ( p < 0.05 at > 0.1 mM ) and the IL-1beta binding to its receptors ( p < 0.05 at 1 mM ) . Positive_regulation MAPK8 IL1B 18065201 1853669 *stimulated* activation of ERK1/2 and p38alpha [MAPK] mediates the transcriptional up-regulation of IL-6 , IL-8 and GRO-alpha in HeLa cells . Positive_regulation MAPK8 IL1B 18348730 1925321 The *activation* or inhibition of p38 [MAPK] by and/or SB203580 was analyzed by western blotting . Positive_regulation MAPK8 IL1B 18348730 1925334 *activated* the phosphorylation of p38 [MAPK] and this effect was abolished by SB203580 . Positive_regulation MAPK8 IL1B 18427719 1920729 Phosphorylated p38 ( Phos-p38 ) [mitogen activated protein kinase] was *stimulated* in SW-1353 cells by but not by HA alone . Positive_regulation MAPK8 IL1B 18556347 1965943 or leptin individually *induced* threonine/tyrosine phosphorylation of p38 [MAPK] , whereas only leptin induced tyrosine phosphorylation of JAK2 , suggesting that leptin may enhance hBD-2 production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with NF-kappaB , which is activated by IL-1beta . Positive_regulation MAPK8 IL1B 18667841 1948058 Furthermore , *induced* p38 [mitogen activated protein kinase (MAPK)] activation and upregulation of VEGF-C mRNA and protein in LLC cells was also suppressed by artemisinin or by the p38 MAPK inhibitor SB-203580 , suggesting that p38 MAPK could serve as a mediator of proinflammatory cytokine induced VEGF-C expression . Positive_regulation MAPK8 IL1B 19362079 2081465 *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 [mitogen activated protein (MAP) kinase] , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation MAPK8 IL1B 19522843 2136345 In chondrocytes , CS diminishes *induced* increases in p38 [mitogen activated protein kinase] ( p38MAPK ) and signal regulated kinase 1/2 ( Erk1/2 ) phosphorylation , and decreases nuclear factor-kappaB (NF-kappaB) nuclear translocation and as a consequence , reduces the formation of pro-inflammatory cytokines , IL-1beta and TNF-alpha , and pro-inflammatory enzymes , such as phospholipase A2 (PLA2) , cyclooxygenase 2 (COX-2) and nitric oxide synthase-2 (NOS-2) . Positive_regulation MAPK8 IL1B 19765281 2163529 Treatment with PIP-18 blocked *induced* p38 [MAPK] phosphorylation and resulted in attenuation of sPLA2-IIA and MMP mRNA transcription in RA SF cells . Positive_regulation MAPK8 IL1B 20060906 2218527 In the present study , we demonstrate that *caused* activation of p38 [mitogen activated protein kinase] and that the p38 inhibitor SB203580 significantly blocked the effect of IL-1beta on I ( NMDA-OUT ) in hippocampal CA1 neurons . Positive_regulation MAPK8 IL1B 20353947 2266486 In model 1 , a differentiation model , CLA *activation* of [MAPK] and induction of interleukin-8 (IL-8) , IL-6 , , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation MAPK8 IL1B 20525168 2284215 We have shown that *induced* miR-146a expression in HASM and that this was regulated at the transcriptional level by NF-kappaB and at the post-transcriptional level by the MEK-1/2 and [JNK-1/2] . Positive_regulation MAPK8 IL1B 21659536 2455200 Distinct roles for Nod2 protein and autocrine in muramyl dipeptide *induced* [mitogen activated protein kinase] activation and cytokine secretion in human macrophages . Positive_regulation MAPK8 IL1B 24692548 2935251 At 1 h , this was responsible for the dexamethasone inhibition of induced [MAPK] *activation* and CXCL1 and CXCL2 mRNA expression , with a similar trend for CSF2 . Positive_regulation MAPK8 IL1B 9475519 486797 Of these , *activated* only [MAPK] . Positive_regulation MAPK8 IL1B 9475519 486810 In cultured rat astrocytes , *caused* activation of [MAPK] without inducing proliferation . Positive_regulation MAPK8 IL1B 9513050 492071 Both [JNK1] and JNK2 were *activated* by . Positive_regulation MAPK8 IL1B 9575890 502753 Our data also indicate that both insulin and IGF-I enhance *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation and SAPK activation . Positive_regulation MAPK8 IL1B 9582321 503942 Previously we reported that *induces* activation of JNK/SAPK and p38 [MAPK] with concomitant up-regulation of cyclooxygenase (Cox)-2 expression and prostaglandin E2 ( PGE2 ) synthesis . Positive_regulation MAPK8 IL1B 9614146 509335 By Western blotting with phosphospecific antibodies and by immunocomplex kinase assay , was shown to *activate* extracellular signal regulated kinase ( ERK ) 1/2 and p38 [mitogen activated protein kinase] ( p38 ) in islets and rat insulinoma cells . Positive_regulation MAPK8 IL1B 9759865 536588 An investigation of MAP kinase signaling pathways revealed that or PDTC *activated* extracellular signal regulated kinase-2 ( ERK-2 ) and [c-jun NH2 terminal kinase-1 (JNK-1)] phosphorylation of PHAS-1 and c-Jun substrates , respectively . Positive_regulation MAPK8 IL1B 9786861 540920 We reported previously that rapidly *activates* the c-Jun NH2-terminal/stress activated protein kinases ( JNK/SAPK ) and p38 [mitogen activated protein kinase (MAPK)] and also induces Cox-2 expression and prostaglandin E2 ( PGE2 ) production . Positive_regulation MAPK8 IL1B 9786861 540966 Overexpression of the kinase-dead form of MKK3 or MKK6 demonstrated that either of these two mutant kinases inhibited *induced* p38 [MAPK] phosphorylation and Cox-2 expression but not JNK/SAPK phosphorylation and activation . Positive_regulation MAPK8 ITGB2 12600815 1099088 IL-3 , IL-5 , and GM-CSF could enhance p38 [MAPK] and NF-kappaB activity and *induce* ICAM-1 , CD11b , and expressions on eosinophils . Positive_regulation MAPK8 ITGB2 19843511 2203207 Furthermore , beta2 integrins modulated the capacity of isolated peritoneal macrophages to take up acetylated LDL and native LDL and to phagocytose apoptotic cells , possibly via *dependent* [mitogen activated protein kinase] signalling . Positive_regulation MAPK8 LBP 20615568 2309971 Despite activating NFkappaB , NOD1 ligand did not upregulate hepatocyte production of the acute phase proteins lipopolysaccharide binding protein , serum amyloid A , or soluble CD14 in cell culture supernatants , or upregulate mRNA expression of , serum amyloid A , C-reactive protein , or serum amyloid P . NOD2 ligand ( MDP ) did not *activate* hepatocytes when given alone , but did synergize with Toll-like receptor ligands , lipopolysaccharide (LPS) , and polyI : C to activate NFkappaB and [MAPK] . Positive_regulation MAPK8 MAP2K6 10050043 592982 In one set of experiments , we *inhibited* the activation of [MAPK] by pretreating cells with PD098059 , a specific inhibitor of ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAPK8 MAP2K6 10079106 595500 Although MKK3 , MKK4 , and all *activated* p38 [MAPk] in experimental models , only MKK3 was found to activate recombinant p38 MAPk in LPS treated neutrophils . Positive_regulation MAPK8 MAP2K6 10224067 609908 Both stress activated protein kinase/extracellular signal regulated kinase kinase ( SEK ) and 7 ( MKK7 ) are immediate upstream *activators* of [JNK1] . Positive_regulation MAPK8 MAP2K6 10471331 641668 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Positive_regulation MAPK8 MAP2K6 10601295 574427 In addition , *activation* of p38 [MAPK] by constitutively active or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAPK8 MAP2K6 10713051 674436 Conversely , the inhibitors PD98059 and UO126 could *attenuate* EGF induced [mitogen activated protein kinase] activation , they do not affect the EGF induced mobility shift of caveolin-1 . Positive_regulation MAPK8 MAP2K6 10759527 683201 These results demonstrate that a plant can phosphorylate and *activate* [MAPK] , and that Tyr phosphorylation is critical for the catalytic activity of MAPK in plants . Positive_regulation MAPK8 MAP2K6 10816593 714753 The MAPK kinase selectively *stimulates* p38 [MAPK] and confers protection against stress induced apoptosis in cardiac myocytes . Positive_regulation MAPK8 MAP2K6 10891559 711245 MAP kinases (MAPK) in both G-1 and G-5 cells were indistinguishably phosphorylated , yet *dependent* [MAPK] activation was observed only in G-5 cells . Positive_regulation MAPK8 MAP2K6 11005808 752472 A inhibitor , PD98059 , *inhibited* heat shock ERK [MAPK] activation by > 75 % . Positive_regulation MAPK8 MAP2K6 11085935 750748 Similarly , *activation* of JNK by Ad-MKK7D and [p38-MAPK] by resulted in the increased expression of PGHS-2 . Positive_regulation MAPK8 MAP2K6 11237743 790357 The MAPK kinase ( ) inhibitor , PD98059 , *blocked* GSA stimulated [MAPK] activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Positive_regulation MAPK8 MAP2K6 11304531 826851 The *activation* of p38 [MAPK] by Galpha ( q ) and Gbetagamma was blocked by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Positive_regulation MAPK8 MAP2K6 11787422 891979 Indeed the MAPK kinase ( = ) inhibitor PD98059 *inhibits* the activation of parasite [MAPK] , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Positive_regulation MAPK8 MAP2K6 11822870 909107 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of [MAPK] pathway *inhibitors* ( inhibitors PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAPK8 MAP2K6 12009309 940865 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Positive_regulation MAPK8 MAP2K6 12203369 983271 Furthermore , PKC inhibitors or an inhibitor completely *suppressed* both TPA induced activation of [MAPK] and promotion of anchorage independent growth , but a cPKC-selective inhibitor partially suppressed TPA induced promotion of the growth . Positive_regulation MAPK8 MAP2K6 12356282 993904 IL-1beta induced p44/42 [mitogen activated protein kinase (MAPK)] activation was *inhibited* by the MAPK/extracellular signal regulated protein kinase ( ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK8 MAP2K6 12377770 1020000 These results suggest that MKK3 , rather than , *mediates* alphav integrin induced p38 [MAPK] activation . Positive_regulation MAPK8 MAP2K6 12450322 1018689 ANG II significantly increased aldosterone release , and this effect was inhibited by the LO inhibitor baicalein , as well as a specific p38 [MAPK] *inhibitor* , SB202190 , but not by PD098059 , a specific inhibitor of the ERK activator . Positive_regulation MAPK8 MAP2K6 12637559 1085546 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Positive_regulation MAPK8 MAP2K6 12659851 1073561 MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a ( MAP2K ) , which in turn *activates* a [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK8 MAP2K6 12845643 1108641 Finally , both ODQ and UO126 blocked the capacity of L-arginine to restore ERK ( 1/2 ) phosphorylation in L-NAME treated cells , demonstrating that GC and are both *required* for endogenous NO-mediated [MAPK] activation . Positive_regulation MAPK8 MAP2K6 15104236 1240363 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( ) inhibitor , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAPK8 MAP2K6 15172888 1288440 Importantly , the presence of inhibitors only at the time of the transport assay markedly *impaired* both insulin stimulated glucose uptake and [MAPK] signaling . Positive_regulation MAPK8 MAP2K6 15172888 1288532 Conversely , removal of inhibitors before the transport assay *restored* glucose uptake and [MAPK] signaling . Positive_regulation MAPK8 MAP2K6 15304546 1322559 Furthermore , *activation* of [ERK/MAPK] by the coexpression of constitutively active predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAPK8 MAP2K6 15365248 1294617 Treatment of keratinocytes with PD98059 , inhibitor , and SB20358 , p38 [MAPK] *inhibitor* , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAPK8 MAP2K6 15570612 1355613 Although the inhibitors *suppressed* [MAPK] phosphorylation in both OA- and AICAR treated oocytes , meiotic resumption was not causally linked to MAPK phosphorylation in either group . Positive_regulation MAPK8 MAP2K6 15867183 1404249 In cultured cardiac myocytes , specific *activation* of stress activated [mitogen activated protein kinase] , p38 , by upstream activator led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAPK8 MAP2K6 15879307 1411364 Conversely , constitutively active *induced* p38 [MAPK] activation that recapitulated the effects of polyphenols by inducing ERalpha phosphorylation and downstream activation of Akt , and eNOS . Positive_regulation MAPK8 MAP2K6 16157033 1455809 SB203580 , a [P38MAPK] *inhibitor* , and U0126 , a inhibitor , both completely blocked ADM mediated responses in MsC . Positive_regulation MAPK8 MAP2K6 17416211 1777933 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK8 MAP2K6 18401006 1925888 CyaA enhanced LPS induced phosphorylation of p38 [MAPK] and ERK in DC , and inhibitors of p38 MAPK , , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation MAPK8 MAP2K6 18754769 1968485 ( MKK) 3 and 6 are the main p38 [mitogen activated protein kinase] *activators* in mammals . Positive_regulation MAPK8 MAP2K6 18771907 1962730 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a inhibitor , and SB203580 , an *inhibitor* of p38 [mitogen activated protein (MAP) kinase] , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAPK8 MAP2K6 21892182 2491669 Further , we show that *activation* of p38 [MAPK] by expression of constitutively active ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAPK8 MAP2K6 22164285 2517917 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of and marked *activation* of p38 [MAPK] . Positive_regulation MAPK8 MAP2K6 22785235 2691943 TRH induced CRE promoter was inhibited by [mitogen activated protein kinase/ERK] kinase ( MEK ) inhibitor and was *increased* by overexpression of . Positive_regulation MAPK8 MAP2K6 7644477 318714 Inhibition of by PD 098059 *prevented* activation of [MAPK] and subsequent phosphorylation of MAPK substrates both in vitro and in intact cells . Positive_regulation MAPK8 MAP2K6 7822248 285647 ( MKK ) phosphorylates and *activates* [mitogen activated protein kinase (MAPK)] in response to stimulation of various eukaryotic signaling pathways . Positive_regulation MAPK8 MAP2K6 7889302 289491 2. Both nucleotides stimulate phosphorylation and *activation* of [mitogen activated protein kinase] and a biphasic phosphorylation of the up-stream . Positive_regulation MAPK8 MAP2K6 8180183 256291 This stimulation of the activator was temporally *followed* by increased activities of MEK and [MAPK] . Positive_regulation MAPK8 MAP2K6 8226933 235462 *Activation* of extracellular signal regulated kinase ( ERK ) or [mitogen activated protein kinase] by ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAPK8 MAP2K6 8394352 228292 We show that a similar activity phosphorylates and *activates* [MAPK] in both growth factor stimulated ( epidermal growth factor and thrombin ) and oncogene ( gip2 , v-src , and v-raf ) -transfected cells . Positive_regulation MAPK8 MAP2K6 8550616 346726 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Positive_regulation MAPK8 MAP2K6 8637721 362429 The over-expression of MUK or in NIH3T3 or COS1 cells *results* in the activation of [JNK1] and the accumulation of a hyper phosphorylated form of c-Jun . Positive_regulation MAPK8 MAP2K6 8663100 368209 The [MAPK] and NHE activities induced by PMA were *inhibited* by staurosporine , a potent inhibitor for protein kinase C ( PKC ) , and by MAPK kinase ( ) inhibitor , PD98059 , but were not affected by the tyrosine kinase inhibitor genistein . Positive_regulation MAPK8 MAP2K6 8663100 368311 In contrast , both AVP induced [MAPK] and NHE activities were *inhibited* by genistein and inhibitor but were not affected by staurosporine . Positive_regulation MAPK8 MAP2K6 8816498 384346 *activates* [mitogen activated protein kinase (MAPK)] , which phosphorylates other kinases as well as transcription factors . Positive_regulation MAPK8 MAP2K6 9135064 427663 In addition to dependent [MAPK] *activation* , we provide evidence for MEK independent regulation of the MAPKs . Positive_regulation MAPK8 MAP2K6 9166761 432511 The first step in [MAPK] *activation* by must be the formation of a MEK x MAPK enzyme-substrate complex , followed by phosphorylation producing monophosphorylated MAPK ( pMAPK ) . Positive_regulation MAPK8 MAP2K6 9626658 511955 These results indicate that *mediates* the IGF-I/insulin induced p42/ p44 [MAPK] activation . Positive_regulation MAPK8 MAP2K6 9864179 582780 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of ERK , but not p38 [MAPK] , induced by G-CSF , GM-CSF , or TNF . Positive_regulation MAPK8 MMP28 11920420 926188 Complete inhibition of expression and joint destruction will likely *require* combined [JNK-1] and JNK-2 inhibition . Positive_regulation MAPK8 MMP7 11920420 926203 Complete inhibition of expression and joint destruction will likely *require* combined [JNK-1] and JNK-2 inhibition . Positive_regulation MAPK8 MMP7 16848631 1588333 and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 [mitogen activated protein kinase] activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MAPK8 MMP7 21999204 2547391 Mesothelin enhances invasion of ovarian cancer by *inducing* through [MAPK/ERK] and JNK pathways . Positive_regulation MAPK8 MUC16 11481474 843954 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a [mitogen activated protein kinase] ( Erk 1/2 ) , and *activation* of transcription . Positive_regulation MAPK8 PECAM1 18029285 1866928 In contrast , expression of Delta15 in PECAM-1-/- bEND cells *had* minimal effects on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Positive_regulation MAPK8 PGC 22105890 2599548 Our studies also revealed that overexpression of in cardiomyocytes *inhibited* basal and T3-induced p38 [MAPK] phosphorylation . Positive_regulation MAPK8 PIGR 20450283 2257154 Induction of expression in HT-29 cells *required* NF-kappaB signaling but not [MAPK] signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation MAPK8 PLAT 19436314 2107045 cerebrospinal fluid and brain parenchymal ERK [MAPK] was elevated by H/I and this upregulation was *potentiated* by , but blunted by RBC-tPA . Positive_regulation MAPK8 PLAT 21037505 2499501 Red blood blocked c-Jun-N-terminal kinase but *potentiated* p38 [mitogen activated protein kinase] upregulation after photothrombotic injury . Positive_regulation MAPK8 PLAU 10766865 684611 surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha [mitogen activated protein kinase] activity . Positive_regulation MAPK8 PLAU 15031204 1257175 In HeLa cells the dominant negative form of JNK interferes with the p42/p44 [MAPK] *activation* of the . Positive_regulation MAPK8 PLAU 15874933 1405704 Activation of the [mitogen activated protein kinases (MAPK)] , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Positive_regulation MAPK8 PLAU 15874933 1405737 Although uPA induced phosphorylation of both ERK1/2 and p38 MAPK was blocked by Galphai inhibition , inhibition of PI3K and Ras decreased the *induced* phosphorylation of ERK1/2 but not p38 [MAPK] . Positive_regulation MAPK8 PLAU 18656457 1960570 Exogenous administered at 4 h post H/I further *stimulated* ERK [MAPK] phosphorylation , which was blocked by RAP . Positive_regulation MAPK8 PLAU 9660790 517505 The receptor *mediates* tyrosine phosphorylation of focal adhesion proteins and activation of [mitogen activated protein kinase] in cultured endothelial cells . Positive_regulation MAPK8 PLAU 9660790 517518 The *induced* activation of [MAPK] was completely inhibited by genistein , but not by 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo [ 3 , 4-d ] pyrimidine , a specific inhibitor of Src family kinases . Positive_regulation MAPK8 PODXL 17616675 1769279 expression also *led* to an increase in [mitogen activated protein kinase (MAPK)] and phosphatidylinositol 3-kinase (PI3K) activity . Positive_regulation MAPK8 PODXL 17616675 1769326 These findings suggest that leads to increased in vitro migration and invasion , increased MMP expression , and *increased* activation of [MAPK] and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MAPK8 PTGER2 19233324 2072065 Further , PGE ( 2 ) , EP2A and EP4A did not increase BMP2/4 mRNA levels in RC cells , and *induced* phosphorylation of p38 [MAPK] was not eliminated by Noggin . Positive_regulation MAPK8 S100B 21209080 2391863 The dependent *activation* of [diaphanous-1/Rac1/JNK/AP-1] , Ras/Rac1/NF-?B and Src/Ras/PI3K/RhoA/diaphanous-1 results in the up-regulation of expression of the chemokines , CCL3 , CCL5 , and CXCL12 , whose release and activity are required for S100B to stimulate microglia migration . Positive_regulation MAPK8 SLC38A3 15331357 1288047 In contrast , *stimulated* [MAPK] activation was blocked by > 80 % by dominant negative Ras but not by dominant negative Rho and Cdc42 . Positive_regulation MAPK8 SNCAIP 12639553 1068709 In addition , [MAPK] was *activated* by through Edg-1 , Sph-1-P receptor . Positive_regulation MAPK8 SPHK1 18602364 1941516 As a result , inhibition of by SKI *blocked* phosphorylation of p38 [MAPK] , showing that SPHK activation by IL-18 is an upstream signal of p38 MAPK activation . Positive_regulation MAPK8 STK39 17237610 1690361 The phosphorylation of cytoplasmic p38 [MAPK] in Akata cells was *reduced* by the inhibitor , 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperazine ( H7 ) . Positive_regulation MAPK8 TGM2 12401808 1036056 Further , by using stable SH-SY5Y cell lines ( overexpressing wild-type , C277S mutant , and antisense TGase ) , we demonstrate that activity is *required* for activation of RhoA , ERK1/2 , [JNK1] , and p38gamma MAP kinases . Positive_regulation MAPK8 TLR7 16424221 1515625 MKP-1-deficient macrophages also show enhanced constitutive and induced *activation* of p38 [MAPK] . Positive_regulation MAPK8 TLR7 23979601 2850705 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Positive_regulation MAPK8 TLR7 24879442 2941056 GIT2 terminates *induced* NF-?B and [MAPK] signaling by recruiting the deubiquitinating enzyme Cylindromatosis to inhibit the ubiquitination of TRAF6 . Positive_regulation MAPK8 TNF 10331740 614762 Inhibition of TNF alpha induced ERK1/2 activity was accompanied by a subsequent transient increase in *induced* [JNK1] activity . Positive_regulation MAPK8 TNF 10504489 648988 Pretreatment with SB203580 ( 10 microM ) had no effect on basal or TNF-alpha stimulated phosphorylation of p38 MAPK but completely abolished *stimulated* p38 [MAPK] activity . Positive_regulation MAPK8 TNF 10521481 653118 The study presented here shows that autoregulation of gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 [mitogen activated protein (MAP) kinase] activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation MAPK8 TNF 10570180 568166 Furthermore , LPS , UV irradiation , and *caused* activation of p38 [MAPK] whereas IFN-gamma did not . Positive_regulation MAPK8 TNF 10601128 574221 alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation MAPK8 TNF 10640438 577515 IL-1 beta and also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK8 TNF 10669634 665813 In this study , we show that *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation MAPK8 TNF 10753884 682348 Moreover , *stimulated* both the NF-kappaB and [mitogen activated protein (MAP) kinase] ( extracellular signal regulated kinase , c-Jun NH ( 2 ) -terminal kinase , and p38 MAP kinase ) signaling pathways in astrocytes . Positive_regulation MAPK8 TNF 10783388 707855 *dependent* p38 [MAPK] activation was detected in both Mo7e and Hut-78 cells and was blocked by the p38 MAPK inhibitor , SB203580 . Positive_regulation MAPK8 TNF 10783388 707908 SB203580 did not affect TNF-alpha signaled nuclear translocation and DNA binding activity of NF-kappaB , and inhibition of NF-kappaB function did not affect *induced* p38 [MAPK] activation , indicating that these events are not dependent on each other . Positive_regulation MAPK8 TNF 10864897 705737 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK8 TNF 10864897 705789 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by and IL-1beta . Positive_regulation MAPK8 TNF 11095634 755305 rapidly *activated* [MAPK] and increased the extent of attachment , spreading and migration on fibronectin and collagen type I ( P < 0.01 ) but not on collagen type IV . Positive_regulation MAPK8 TNF 11108246 756734 *activates* extracellular regulated kinase-1/2 ( ERK1/2 ) and [p38MAPK] . Positive_regulation MAPK8 TNF 11108836 757045 In RAW264 cells which differentiate into osteoclast-like multinucleated cells by TNF treatment alone , activation of p38 [mitogen activated protein (MAP) kinase] *induced* by murine was comparable to and independent of the receptor activator of necrosis factor-kappaB ligand . Positive_regulation MAPK8 TNF 11156586 780621 1. We have previously shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce interleukin-8 (IL-8) by human pulmonary vascular endothelial cells . Positive_regulation MAPK8 TNF 11167962 783072 It has previously been shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce cytokine , including RANTES , that N-acetylcysteine (NAC) attenuates cytokine production by human bronchial epithelial cells ( BECs ) , and that sensitivity to TNFalpha is inversely correlated with cellular redox state . Positive_regulation MAPK8 TNF 11266661 797175 However , *caused* no activation of p42/p44 [MAPK] or cytosolic phospholipase A(2) activity . Positive_regulation MAPK8 TNF 11277995 798117 *activates* extracellular regulated kinases ( ERKs ) and p38 [mitogen activated protein kinase] ( p38MAPK ) , and inhibits the expression of uncoupling protein-1 (UCP-1) and adipocyte-specific genes in rat fetal brown adipocytes . Positive_regulation MAPK8 TNF 11319753 806845 SB 203580 , a selective inhibitor of p38 MAPK , inhibited IL-1 and *induced* p38 [MAPK] activity and IL-6 production ( IC ( 50 ) s 0.3 -- 0.5 microM ) in osteoblasts and chondrocytes . Positive_regulation MAPK8 TNF 11319753 806880 In addition , IL-1 and also *activated* p38 [MAPK] in fetal rat long bones and p38 MAPK inhibitors inhibited IL-1- and TNF stimulated bone resorption in vitro in a dose dependent manner ( IC ( 50 ) s 0.3 -- 1 microM ) . Positive_regulation MAPK8 TNF 11435466 832535 However , the cytotoxic responses to daunorubicin and exogenous ceramide remain unaltered , as do the induced p42/p44 [MAPK] *activation* and CD54 expression . Positive_regulation MAPK8 TNF 11438547 843400 *activated* p38 [MAPK] and p44/p42 MAPK in wild-type but not in p60 ( -/- ) , p80 ( -/- ) , or p60 ( -/- ) p80 ( -/- ) macrophages . Positive_regulation MAPK8 TNF 11448159 835680 In addition , lower doses of Tat potentiated *induced* [JNK1] activation , although higher doses paradoxically diminished JNK1 activation by TNFalpha . Positive_regulation MAPK8 TNF 11494147 846179 In this study we demonstrate that *triggers* only modest proliferation , as well as p44/p42 [mitogen activated protein kinase (MAPK)] and NF-kappaB activation , in MM.1S multiple myeloma ( MM ) cells . Positive_regulation MAPK8 TNF 11495721 846404 Furthermore , overexpression of dominant negative mutants , H-Ras-15A and Raf-N4 , significantly suppressed p42/p44 [mitogen activated protein kinase (MAPK)] activation *induced* by and PDGF-BB and attenuated the effect of TNF-alpha on BK-induced IP response , indicating that Ras and Raf may be required for activation of these kinases . Positive_regulation MAPK8 TNF 11509550 848378 Although IL-1 beta and each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK8 TNF 11592111 869673 Lipopolysaccharide (LPS) treatment of a microglial cell line ( N9 ) *induced* a time dependent activation of both p38 mitogen activated protein kinase ( p38 [MAPK] ) and nuclear factor-kappaB (NFkappaB) , with consequent increases in interleukin-1alpha (IL-1alpha) , , and nitric oxide ( NO ) production . Positive_regulation MAPK8 TNF 11694522 896420 *activated* the three mammalian [MAPK] , p44/42 , JNK , and p38 , in a distinct time- and concentration dependent manner . Positive_regulation MAPK8 TNF 11694522 896446 In conclusion , although *activates* all three known [MAPK] in human preadipocytes , only p44/42 and JNK appear to be involved in the regulation of lipolysis . Positive_regulation MAPK8 TNF 11750919 898178 Biochemical and immunocytochemical analysis showed that *activated* p38 [mitogen activated protein kinase] ( p38MAPK ) and c-Jun N-terminal kinase (JNK) but not p42/p44 MAPK . Positive_regulation MAPK8 TNF 11820362 908745 *activated* p38 [MAPK] and stimulated IL-6 secretion by MG-63 cells , and pre-incubation of cells with the p38 MAPK inhibitor abrogated TNF-alpha dependent IL-6 secretion . Positive_regulation MAPK8 TNF 11820362 908774 Transfection of IL-6 full-length and 5-deletion gene promoter reporter constructs indicated that p38 [MAPK] *activation* by enhanced IL-6 gene expression , and that the p38 MAPK-responsive region resided in the proximal 260-bp segment . Positive_regulation MAPK8 TNF 11820362 908810 In conclusion , although p38 [MAPK] *activation* by stimulates IL-6 secretion by MG-63 cells , it has opposing effects on c/EBPbeta and NFkappaB activity . Positive_regulation MAPK8 TNF 11930247 927425 The p44/42 [MAPK] activity was significantly *enhanced* by and the TNF-alpha effect was opposed by rhIL-10 . Positive_regulation MAPK8 TNF 11930247 927438 It is suggested that rhIL-10 can inhibit *induced* VSMC proliferation and phosphorylation of p44/42 [MAPK] . Positive_regulation MAPK8 TNF 12095140 960571 significantly increased permeability and *induced* p38 and ERK [MAPK] activation compared with controls ( P < 0.05 ) . Positive_regulation MAPK8 TNF 12114204 964001 *increased* the phosphorylation of p38 MAPK within 15 min. Anisomycin , an activator of p38 MAPK , increased p38 [MAPK] phosphorylation and decreased SP-A mRNA levels in a dose dependent manner . Positive_regulation MAPK8 TNF 12130576 966592 Phosphorylation of p38 [MAPK] was *induced* by RANKL , IL-1 , , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation MAPK8 TNF 12131776 966870 IL-1 beta and *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK8 TNF 12297009 991044 In this study , we examined the anti-apoptotic role of p38 [MAPK] that is *activated* by in neuronal PC12 cells . Positive_regulation MAPK8 TNF 12297009 991057 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Positive_regulation MAPK8 TNF 12393915 1025447 This model probiotic also inhibits *activation* of the pro-apoptotic [p38/mitogen activated protein kinase] by , interleukin-1alpha , or gamma-interferon . Positive_regulation MAPK8 TNF 12511413 1079055 The treatment of RAW264 cells with TSA and NaB inhibited *induced* nuclear translocation of NF-kappa B and sRANKL induced activation of p38 [mitogen activated protein kinase (MAPK)] signals . Positive_regulation MAPK8 TNF 12631113 1067622 Additional experiments examining the role of cAMP on MC fractalkine expression showed that the incubation of MCs with TNF-alpha and either db-cAMP or forskolin attenuated TNF-alpha stimulated fractalkine mRNA and protein expression , preceded by attenuation of *activated* phosphorylation of p42/44 [MAPK] , and c-Jun , but not phosphorylation of PKCzeta/iota or nuclear translocation of NF-kappaB . Positive_regulation MAPK8 TNF 12637577 1099326 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and *requires* p38 [MAPK] activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation MAPK8 TNF 12665666 1030377 This study was undertaken to examine the relationship between *induced* cardiomyocyte apoptosis and activation of p38 [mitogen activated protein kinase (MAPK)] through oxidative stress . Positive_regulation MAPK8 TNF 12665666 1030390 Corresponding to the apoptotic effect , at 10 ng/mL *caused* rapid phosphorylation of p38 [MAPK] in wild-type cardiomyocytes . Positive_regulation MAPK8 TNF 12694807 1080916 *induced* the phosphorylation of p44/p42 [mitogen activated protein (MAP) kinase] and p38 MAP kinase . Positive_regulation MAPK8 TNF 12731668 1086852 On the other hand , GM-CSF- or *induced* phosphorylation of ERK and p38 [MAPK] was unaffected by these inhibitors at the concentrations effective for the inhibition of O2- release and adherence . Positive_regulation MAPK8 TNF 12829618 1113811 However , *induced* [p38-MAPK] phosphorylation was markedly diminished in mkk3-/- vs mkk3+/+ hearts ( percent basal , 127+/-23 versus 540+/-267 , respectively , P=0.04 ) , suggesting an MKK independent activation mechanism by ischemia . Positive_regulation MAPK8 TNF 12844496 1149735 Rho inhibition decreases *induced* endothelial [MAPK] activation and monolayer permeability . Positive_regulation MAPK8 TNF 12844496 1149748 Because GTP binding proteins have been implicated in MAPK activation , we now hypothesize that the GTP binding protein Rho is a mediator of induced [MAPK] *activation* and increased endothelial permeability . Positive_regulation MAPK8 TNF 12844496 1149762 C3 transferase attenuated *induced* [MAPK] activation and blocked TNF induced endothelial permeability . Positive_regulation MAPK8 TNF 12867430 1142028 Subsequently , mediated p38 [MAPK] *activation* induced sialidase activity and CD44-HA binding . Positive_regulation MAPK8 TNF 12867430 1142112 Taken together , our results suggest that *induced* p38 [MAPK] activation may regulate the induction of functionally active HA-binding form of CD44 by activating sialidase in LPS stimulated human monocytic cells . Positive_regulation MAPK8 TNF 12881424 1116137 Importantly , does not *induce* ROS accumulation or prolonged [MAPK] activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death Positive_regulation MAPK8 TNF 12893778 1121035 We show that MKK3 and MKK6are essential for *stimulated* p38 [MAPK] activation . Positive_regulation MAPK8 TNF 12960255 1158293 To investigate a potential interplay between *induced* activation of p38 [MAPK] and NF-kappaB , the p38 MAPK inhibitor SB203580 and a dominant negative p38 MAPK mutant were used . Positive_regulation MAPK8 TNF 14516792 1147209 [MAPK] pathway *activation* via was confirmed by marked AP-1 activation detected in EMSA . Positive_regulation MAPK8 TNF 14561851 1165111 In cultured human umbilical vein endothelial cells ( HUVECs ) , and lipopolysaccharide *increased* phosphorylation of p38 [MAPK] ( P-p38 MAPK ) and increased ICAM-1 expression . Positive_regulation MAPK8 TNF 14592823 1209470 Analyzing the individual contribution of PF-4 and its costimuli in the control of these functions at the signaling level , we demonstrate that induced *activation* of p38 [mitogen activated protein (MAP) kinase] ( but not extracellular regulated kinase [ Erk ] kinases ) acts as general and essential costimulatory signal in PF-4 dependent neutrophil exocytosis . Positive_regulation MAPK8 TNF 14632659 1170656 *activated* p38 [MAPK] in DCs only at an early time-point ( 15 min ) . Positive_regulation MAPK8 TNF 14654378 1176834 These findings suggest that the pre-ischemic *activation* of [p38-MAPK] by does not contribute to cardioprotection afforded by this agent . Positive_regulation MAPK8 TNF 15002040 1265092 Consistent with the abrogation of osteoclastogenic effect of DcR3 by TNFR-Fc , DcR3 treatment can *induce* osteoclastogenic cytokine release through ERK and p38 [MAPK] signaling pathways . Positive_regulation MAPK8 TNF 15139014 1246963 The increase in release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not [mitogen activated protein kinase (MAPK)] , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation MAPK8 TNF 15191888 1295245 Treatment of endothelial cells with SphK1 siRNA suppressed *induced* increase in MCP-1 mRNA levels , MCP-1 protein secretion , and activation of p38 [MAPK] . Positive_regulation MAPK8 TNF 15212763 1262328 Interestingly , Ad5NIK , but not , *induces* RelA S536 and p38 [mitogen activated protein kinase (MAPK)] phosphorylation in IKKgamma ( -/- ) cells . Positive_regulation MAPK8 TNF 15231489 1295765 To explore this regulation , we first observed that in the continuous *presence* of cytokine , activation of [JNK-1] in both nuclear and cytoplasmic compartments peaked at 15-30 min , with activity returning to uninduced levels by 60 min. Phosphorylation of both the p38 kinase and its molecular target , the nuclear transcription factor , activating transcription factor-2 , were transient after TNF-alpha or interleukin (IL)-1beta induction . Positive_regulation MAPK8 TNF 15231489 1295766 However , cycloheximide treatment prolonged the *induced* [JNK-1] kinase activity beyond 60 min , suggesting that protein synthesis is required to limit this signaling cascade . Positive_regulation MAPK8 TNF 15233873 1269396 A. semen also inhibited the expression of and the *activation* of [mitogen activated protein kinase] , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation MAPK8 TNF 15240695 1270288 TNF activates Syk protein tyrosine kinase leading to induced [MAPK] *activation* , NF-kappaB activation , and apoptosis . Positive_regulation MAPK8 TNF 15240695 1270308 TNF induced Syk activation was abolished by piceatannol ( Syk-selective inhibitor ) , which led to the suppression of induced *activation* of c- JNK , p38 [MAPK] , and p44/p42 MAPK . Positive_regulation MAPK8 TNF 15240695 1270324 Jurkat cells that did not express Syk ( JCaM1 , JCaM1/lck ) showed lack of *induced* Syk , JNK , p38 [MAPK] , and p44/p42 MAPK activation , as well as TNF induced IkappaBalpha phosphorylation , IkappaBalpha degradation , and NF-kappaB activation . Positive_regulation MAPK8 TNF 15240695 1270355 Overall , our results demonstrate that Syk activation plays an essential role in induced *activation* of JNK , p38 MAPK , p44/p42 [MAPK] , NF-kappaB , and apoptosis . Positive_regulation MAPK8 TNF 15240725 1270463 p38 [MAPK] was *activated* by and oxidants in nonadherent conditions i.e. , with 10 mM EDTA . Positive_regulation MAPK8 TNF 15240725 1270477 Finally , p38 [MAPK] *activation* by was blocked by diphenylene iodonium , an inhibitor of flavoprotein oxidoreductase , and by the free radical scavenger N-acetylcystein . Positive_regulation MAPK8 TNF 15265936 1275739 Besides NF-kappa B , celecoxib also suppressed *induced* JNK , p38 [MAPK] , and ERK activation . Positive_regulation MAPK8 TNF 15290420 1278556 Halothane or isoflurane augmented the LPS- and *induced* activation of p38 [MAPK] . Positive_regulation MAPK8 TNF 15304089 1284485 DNCB , NiSO ( 4 ) and *activated* p38 [mitogen activated protein kinases (MAPK)] and c-jun N-terminal kinase ( JNK ) . Positive_regulation MAPK8 TNF 15322069 1333427 We have also investigated the phosphorylation of p42/44 [MAPK] and *upregulation* of RhoA protein by . Positive_regulation MAPK8 TNF 15452110 1341998 In contrast , induced p42/p44 [MAPK] *activation* and CD54 expression remained unaltered . Positive_regulation MAPK8 TNF 15572687 1344376 Using mouse fibroblasts deficient in either Jnk1 or Jnk2 , we found that [JNK1] was *activated* by , whereas JNK2 activation was negligible . Positive_regulation MAPK8 TNF 15589482 1356218 In addition , luteolin inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , IkappaB degradation , and NF-kappaB activation . Positive_regulation MAPK8 TNF 15659876 1350318 The anabolic effect of was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an extracellular regulated kinases (ERK) . Positive_regulation MAPK8 TNF 15696169 1372172 Using TCPTP-deficient fibroblasts , we show here that TCPTP regulates *induced* [MAPK] but not NF-kappaB signaling . Positive_regulation MAPK8 TNF 15696169 1372207 These results link TCPTP and Src tyrosine kinases to the selective regulation of *induced* [MAPK] signaling and identify a previously unknown mechanism for modulating inflammatory responses mediated by TNF . Positive_regulation MAPK8 TNF 15703956 1497474 *Activation* of p38 [mitogen activated protein (MAP) kinase] and phosphatidylinositol 3-kinase (PI3K) by was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation MAPK8 TNF 15792609 1386800 By stimulation of in AM-1 cells , the phosphorylation of Akt ( Ser473 ) and p44/42 [mitogen activated protein kinase (MAPK)] ( Thr202/Tyr204 ) was markedly *increased* in TNFalpha concentration and time dependent manner . Positive_regulation MAPK8 TNF 15792609 1386813 Pretreatment with U0126 , mitogen activated extracellular regulated kinase ( MEK) 1/2 inhibitor , prior to TNFalpha stimulation , specifically inhibited *induced* phosphorylation of p44/42 [MAPK] ( Thr202/Tyr204 ) in AM-1 cells . Positive_regulation MAPK8 TNF 15792609 1386829 Meanwhile , pretreatment with LY294002 , phosphatidylinositol-3-OH kinase (PI3K) inhibitor , could inhibit both *induced* phosphorylation of Akt ( Ser473 ) and p44/42 [MAPK] ( Thr202/Tyr204 ) . Positive_regulation MAPK8 TNF 15823554 1393918 Furthermore , potently *activated* p38 [MAPK] , JNK , and NF-kappaB . Positive_regulation MAPK8 TNF 15837794 1432555 Expression of this protein inhibited induced *activation* of NFkappaB , JNK , and p38 [MAPK] and sensitized the cells to TNF induced apoptosis . Positive_regulation MAPK8 TNF 15845648 1425553 *induces* a more than tenfold increase in p38 [mitogen activated protein kinase (MAPK)] but not extracellular signal regulated kinase phosphorylation . Positive_regulation MAPK8 TNF 15870903 1405553 In addition , GA inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , I kappa B alpha degradation , and NF-kappa B activation . Positive_regulation MAPK8 TNF 16009485 1441415 Moreover , p44/42 [mitogen activated protein kinase] appears to partly *mediate* the negative effect of insulin but not on ATGL . Positive_regulation MAPK8 TNF 16023081 1441594 Ellagic acid inhibited IL-1beta- and induced *activation* of activator protein-1 and mitogen activated protein kinases ( extracellular signal regulated kinase , c-Jun N-terminal kinase and p38 [mitogen activated protein kinase] ) , but not of nuclear factor-kappaB . Positive_regulation MAPK8 TNF 16025396 1435617 *activated* the phosphorylation of p44/42 [MAPK] , p38 MAPK , SAPK/JNK and Akt in mesangial cells . Positive_regulation MAPK8 TNF 16025396 1435633 PGE1 inhibited the *induced* phosphorylation of SAPK/JNK and Akt , but not p44/42 MAPK and p38 [MAPK] . Positive_regulation MAPK8 TNF 16080915 1442773 Comparative gene array analysis of *induced* [MAPK] and NF-kappaB signaling pathways between retinal ganglion cells and glial cells . Positive_regulation MAPK8 TNF 16140562 1499259 These results suggested that TNFalpha induced both cell survival and apoptosis pathways in ameloblastoma and potential of TNFalpha in inducing apoptosis can be improved by inhibiting *induced* Akt and p44/42 [mitogen activated protein kinase (MAPK)] cell survival pathways . Positive_regulation MAPK8 TNF 16275991 1480312 Angiotensin II , , or epidermal growth factor *induced* [MAPK] phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation MAPK8 TNF 16291729 1526076 *Activation* of [MAPK] and Akt by anti-HER2/neu inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation MAPK8 TNF 16314440 1487005 treatment *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation in NPCs , and SB202190 , an inhibitor of p38 MAPK , blocked TNF-alpha induced chemokine production . Positive_regulation MAPK8 TNF 16325162 1511670 Furthermore , APE1/ref-1 overexpression inhibited the *induced* increase in intracellular superoxide and p38 [MAPK] phosphorylation . Positive_regulation MAPK8 TNF 16452991 1611748 Western blots showed that IL-1beta and *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK8 TNF 16517732 1530948 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of , but not IL-6 , *requires* the activity of p38 [MAPK] . Positive_regulation MAPK8 TNF 16573652 1556142 HA-mediated production *required* p38 [MAPK] , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation MAPK8 TNF 16682409 1584063 Further , the deletion of NQO1 abolished induced c-Jun N-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] *activation* . Positive_regulation MAPK8 TNF 16781693 1585621 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and and the *activation* of [MAPK] 's are potentially positive signals for IL-10 production . Positive_regulation MAPK8 TNF 16798728 1638516 Inhibition of Rac1 before the administration of apoptotic stimuli significantly prevents *induced* activation of [JNK1/2] , the key proapoptotic regulator in IEC-6 cells . Positive_regulation MAPK8 TNF 16798728 1638540 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Positive_regulation MAPK8 TNF 16875982 1593568 *activates* [p38-MAPK] , a stress-responsive kinase implicated in contractile depression and cardiac injury . Positive_regulation MAPK8 TNF 16875982 1593582 Under conditions of constant coronary flow , the [p38-MAPK] activation and contractile depression *induced* by , though attenuated , remained sensitive to the absence of MKK3 or the presence of SB203580 . Positive_regulation MAPK8 TNF 16875982 1593596 *activates* [p38-MAPK] in the intact heart and in isolated cardiac myocytes through MKK3 . Positive_regulation MAPK8 TNF 16982923 1617368 Compared with wild-type cells , MIF-deficient cells were hyporesponsive to IL-1- and *induced* [MAPK] activity , AP-1 activity , and cellular proliferation , while NF-kappaB function was preserved . Positive_regulation MAPK8 TNF 17070777 1649844 Inhibition of Syk down-regulated *induced* p38 and p44/42 [MAPK] phosphorylation and nuclear translocation of p65 NF-kappaB . Positive_regulation MAPK8 TNF 17099067 1676206 Importantly , Dex is able to increase the expression of MKP-1 , which causes an inactivation of *induced* p38 [MAPK] and mediates inhibition of E-selectin expression . Positive_regulation MAPK8 TNF 17126899 1677679 Stimulation of ECs with *induced* rapid increases in the phosphorylation of their mitogen activated protein kinases ( MAPKs ) [ extracellular signal regulated kinase ( ERK ) , c-Jun-NH2-terminal kinase (JNK) , and p38 [MAPK] ] ; Positive_regulation MAPK8 TNF 17126905 1686559 Differential regulation of and GM-CSF *induced* activation of P38 [MAPK] in neutrophils and eosinophils . Positive_regulation MAPK8 TNF 17138860 1653552 The role of delta-PKC in *mediated* activation of [MAPK] is not known . Positive_regulation MAPK8 TNF 17138860 1653578 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 MAPK are involved in TNF antiapoptotic signaling and whether delta-PKC is a key regulator of [MAPK] *activation* by . Positive_regulation MAPK8 TNF 17138860 1653604 In human neutrophils , *activated* both p38 [MAPK] and ERK1/2 principally via TNFR-1 . Positive_regulation MAPK8 TNF 17158449 1694272 A green fluorescent protein fusion protein containing the last 100 residues of TAK1 ( TAK1-C100 ) abolished the interaction of endogenous TAB2/TAB3 with TAK1 , the phosphorylation of TAK1 , and prevented the activation of IKK and [MAPK] *induced* by IL-1 , , and RANKL . Positive_regulation MAPK8 TNF 17161959 1694544 Upon examination of the signaling components , we found that was a potent *activator* of p38 , p44/42 , p54/46 [MAPK] , and IkappaBalpha ( IkappaBalpha ) . Positive_regulation MAPK8 TNF 17172975 1679392 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the [MAPK] , and production of . Positive_regulation MAPK8 TNF 17172975 1679418 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the [MAPK] , and production of . Positive_regulation MAPK8 TNF 17189827 1680177 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Positive_regulation MAPK8 TNF 17202326 1680820 Augmented lipopolysaccharide induced production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK8 TNF 17202326 1680846 In this study , we show that augmented LPS induced production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK8 TNF 17218473 1732527 The RhoA inhibitor C3 exoenzyme and the ROCK inhibitor Y-27632 both attenuated induced [MAPK] *activation* and blocked AR expression in HIMEC . Positive_regulation MAPK8 TNF 17220297 1703059 TRAF2 and ASK1 play essential roles in *induced* [mitogen activated protein kinase] signaling . Positive_regulation MAPK8 TNF 17258890 1725464 The effects of and FasL on GrB expression were specifically *mediated* by [p38MAPK] ( Mitogen-activated-protein-kinase ) activation . Positive_regulation MAPK8 TNF 17425653 1748789 The percentage increases in IL-18 induced phosphorylation of extracellular signal regulated kinase ( ERK ) in Th cells of NDN and DN were significantly higher than controls ( P < 0.05 ) , while the percentage increase in *induced* phosphorylation of p38 [MAPK] in monocytes and IL-18 induced phosphorylation of p38 MAPK in Th cells and monocytes were significantly higher in NDN patients than controls . Positive_regulation MAPK8 TNF 17438131 1742785 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation MAPK8 TNF 17438336 1749081 FAK promoted *stimulated* [MAPK] activation needed for maximal IL-6 production . Positive_regulation MAPK8 TNF 17438336 1749107 Analysis of FAK ( -/- ) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity , Tyr-397 phosphorylation , and the Pro-712/713 proline-rich region of FAK were required for *stimulated* [MAPK] activation and IL-6 production . Positive_regulation MAPK8 TNF 17446186 1749516 *increased* p38 [MAPK] phosphorylation , potently stimulated IRS-1 serine phosphorylation , and blunted insulin stimulated IRS-1 tyrosine and Akt phosphorylation and eNOS activity . Positive_regulation MAPK8 TNF 17531219 1762176 On the other hand , aloe emodin did not affect *induced* activation of p38 [mitogen activated protein kinase] or generation of reactive oxygen species . Positive_regulation MAPK8 TNF 17567906 1763224 In *response* to , Zfra is upregulated and modulates TNF mediated cell death via interacting with TRADD , FADD and RIP ( death inducing signaling complex ) at the receptor level , and downstream effectors NF-kappaB , p53 , WOX1 , and [JNK1] . Positive_regulation MAPK8 TNF 17607712 1798195 Although *induced* the activation of p38 [MAPK] , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation MAPK8 TNF 17725582 1801640 MAC inhibited *induced* p38 [mitogen activated protein kinase] activation and cell death in cultured Schwann cells . Positive_regulation MAPK8 TNF 17895408 1823971 IA did not interfere with induced *activation* of c-Jun N-terminal kinase (JNK) and p38 [mitogen activated protein kinase] . Positive_regulation MAPK8 TNF 17942934 1814220 Deletion of NQO2 also abolished induced c-Jun NH2-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] *activation* . Positive_regulation MAPK8 TNF 17994109 1851168 triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 [MAPK] , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation MAPK8 TNF 18039275 1828534 Further downstream in this axis of signalling , blockade *reduces* only acute bronchoconstriction , while [MAPK] inhibition abrogates completely endotoxin induced inflammation . Positive_regulation MAPK8 TNF 18060043 1853608 In cultures of Schwann cells , astrocytes , and microglia , sLRP-alpha inhibited *induced* activation of p38 MAPK and [ERK/MAPK] . Positive_regulation MAPK8 TNF 18061162 1861522 We demonstrate that *induced* proliferation of C4HD murine mammary tumor cells and of T47D cells through the activation of p42/p44 [MAPK] , JNK , PI3-K/Akt pathways and nuclear factor-kappa B (NF-kappa B) transcriptional activation . Positive_regulation MAPK8 TNF 18091748 1847373 *induced* phosphorylation of extracellular signal regulated kinase ( ERK ) and Akt , but not p38 [mitogen activated protein kinase (MAPK)] , was attenuated by nicardipine , cilnidipine , benidipine , efonidipine , and azelnidipine . Positive_regulation MAPK8 TNF 18227157 1884376 It was shown that these three proteins could ( i ) induce expression of and tissue factor and ( ii ) *induce* phosphorylation of p44/42 [mitogen activated protein kinases (MAPK)] and activation of early growth response factor 1 (Egr-1) . Positive_regulation MAPK8 TNF 18258304 1884802 However , over-expression of a dominant negative form of Rac strongly inhibited *induced* p42/44 [MAPK] kinase activation , but had little effect upon JNK and no effect upon p38 MAPK activity . Positive_regulation MAPK8 TNF 18287053 1872495 Here , we show that the murine CMV M45 protein binds to RIP1 and inhibits *induced* activation of NF-kappaB , p38 [MAPK] , and caspase independent cell death . Positive_regulation MAPK8 TNF 18287248 1896531 Flavopiridol suppresses induced *activation* of activator protein-1 , c-Jun N-terminal kinase , p38 mitogen activated protein kinase (MAPK) , p44/p42 [MAPK] , and Akt , inhibits expression of antiapoptotic gene products , and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells . Positive_regulation MAPK8 TNF 18314542 1931912 P < 0.05 ) , and MKP-1 up-regulation was temporally related to the inhibition of *induced* p38 [MAPK] phosphorylation . Positive_regulation MAPK8 TNF 18336852 1912246 *stimulated* phosphorylation of p42/p44 [MAPK] and JNK were attenuated by pretreatment with the inhibitors U0126 and SP600125 or transfection with dominant negative mutants of DeltaERK and DeltaJNK . Positive_regulation MAPK8 TNF 18364436 1912774 We , for the first time , demonstrate that binding of staphylococcal enterotoxin B to MHC-II results in activation of TNF-alpha converting enzyme , epidermal growth factor receptor , [p38MAPK] , and NF-kappaB *inducing* biphasic production . Positive_regulation MAPK8 TNF 18443205 1938532 Conversely , *induced* increases in insulin receptor substrate-1 serine phosphorylation ( Ser ( 312 ) ) , Jun NH ( 2 ) -terminal kinase phosphorylation , and extracellular signal related kinase-1/2 [mitogen activated protein kinase (MAPK)] phosphorylation were unaltered by siRNA mediated IKKbeta reduction . Positive_regulation MAPK8 TNF 18518937 1971926 Although Cot/Tpl2 was phosphorylated in IRI and in the cultured tubular epithelial cells (TEC) after stimulation with LPS and hydrogen peroxide , there were no significant differences in terms of production , neutrophil infiltration or [MAPK] *activation* between Cot/Tpl2 ( +/+ ) and Cot/Tpl2 ( -/- ) mice . Positive_regulation MAPK8 TNF 18636175 1937276 Furthermore , glucosamine inhibited the *induced* phosphorylation of [p38MAPK] and NF-kappaB p65 , and the nuclear translocation of NF-kappaB in the cells . Positive_regulation MAPK8 TNF 18653803 1960523 PMA stimulated nSMase2 translocation was independent of p38 MAPK , and neither PKC inhibitors nor small interfering RNA had significant effects on *stimulated* p38 [MAPK] activation , indicating that PKC-delta does not act through p38 MAPK in regulating nSMase2 . Positive_regulation MAPK8 TNF 18710428 2028207 As for the signalling pathway , stimulation *led* to the phosphorylation of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and translocation of nuclear factor kappaB (NF-kappaB) ( p65 ) into the nuclei . Positive_regulation MAPK8 TNF 18710428 2028235 These data suggest that interaction *leads* to the phosphorylation of Erk1/2 and [p38MAPK] and nuclear translocation of NF-kappaB , which is closely associated with the production and activation of MMP-9 in cultured CC cells of HuCTT-1 and CCKS-1 . Positive_regulation MAPK8 TNF 18768892 1957237 Consistently , Nod2-null macrophages tolerant to LPS and MDP showed enhanced production of and IL-6 as well as increased NF-kappaB and [MAPK] *activation* in response to the dipeptide KF1B , the Nod1 agonist . Positive_regulation MAPK8 TNF 18948845 2053246 Hypertonic saline did not alter *induced* p38 [mitogen activated protein kinase] phosphorylation or constitutive vascular endothelial growth factor expression , suggesting that the observed inhibition is not a generalized suppression of protein phosphorylation or cellular function . Positive_regulation MAPK8 TNF 19056926 2029893 [JNK1] stimulated and *mediated* the effects of IFN and on XAF1 expression through transcriptional regulation by induction of IRF-1 . Positive_regulation MAPK8 TNF 19100731 2031227 at 30 ng/ml significantly *increased* phosphorylation of receptor tyrosine kinase ( 175 kDa ) and p42 [mitogen activated protein (MAP) kinase] . Positive_regulation MAPK8 TNF 19130554 2025306 Stimulation of HIMEC with *triggered* phosphorylation of the [MAPK] , and up-regulation of VCAM-1 , FKN and ICAM-1 . Positive_regulation MAPK8 TNF 19234337 2079516 Analysis of downstream signals showed that inhibition of NAD(P)H oxidase partially inhibited NF-kappaB activation but did not reduce CCL2 mRNA stability or prevent *induced* phosphorylation of [p38MAPK] . Positive_regulation MAPK8 TNF 19275968 2072850 *stimulated* the phosphorylation levels of p38 [MAPK] , JNK , ERK1/2 and Akt in vascular endothelial cells . Positive_regulation MAPK8 TNF 19289468 2073044 The requirement for MADD was highly specific for *induced* activation of [MAPK] but not the related JNK and p38 kinases . Positive_regulation MAPK8 TNF 19371952 2081768 Of note , the IFN-gamma plus *stimulated* activation of p38 [MAPK] was suppressed following incubation with forskolin or DBcAMP alone . Positive_regulation MAPK8 TNF 19410630 2089701 By transfection of TAK1 siRNA , *induced* phosphorylation of IkappaBalpha , JNK1/2 , and [p38MAPK] , as well as IL-6 or IL-8 expression , were repressed . Positive_regulation MAPK8 TNF 19427347 2106800 *induced* the phosphorylation of p38 [mitogen activated protein (MAP) kinase] , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation MAPK8 TNF 19429670 2106875 Ang II and clearly *enhanced* ERK and [p38MAPK] phosphorylation . Positive_regulation MAPK8 TNF 19563733 2122014 Finally , EZS inhibited *induced* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phosphorylation . Positive_regulation MAPK8 TNF 19567513 2129040 [c-Jun N-terminal kinase 1/2] *activation* by induces insulin resistance in human visceral but not subcutaneous adipocytes : reversal by liver X receptor agonists . Positive_regulation MAPK8 TNF 19567513 2129045 Pharmacological treatment of adipocytes with liver X receptor agonists reestablished insulin sensitivity by impairing *induction* of [JNK1/2] , phosphorylation of IRS1 ( Ser312 ) , and stabilizing IL-6 secretion . Positive_regulation MAPK8 TNF 19648110 2138337 This correlates with reduced *stimulated* p38 [MAPK] phosphorylation . Positive_regulation MAPK8 TNF 19648110 2138352 Repression of *induced* p38 [MAPK] phosphorylation , NF-kappaB dependent transcription , and IL-8 expression by dexamethasone are sensitive to transcriptional or translational inhibitors . Positive_regulation MAPK8 TNF 19648110 2138423 Thus , MKP-1 attenuates dependent *activation* of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Positive_regulation MAPK8 TNF 19648110 2138450 Small interfering RNA knockdown of dexamethasone induced MKP-1 expression partially reverses the repression of *activated* p38 [MAPK] , demonstrating that MKP-1 participates in the dexamethasone dependent repression of this pathway . Positive_regulation MAPK8 TNF 19788916 2163928 ( TNF-alpha ) and H ( 2 ) O ( 2 ) *activate* [mitogen activated protein kinase (MAPK)] in SH-SY5Y cells within 5 min and this activation is completely blocked by DLPC ( 12 microM ) . Positive_regulation MAPK8 TNF 19877072 2160717 CpdA also displayed profound effects on induced [MAPK] *activation* . Positive_regulation MAPK8 TNF 19877072 2160734 In sharp contrast , DEX did not affect induced IKK phosphorylation , IkappaBalpha degradation , p65 nuclear translocation , or [MAPK] *activation* in RA FLS . Positive_regulation MAPK8 TNF 19889458 2197309 Calpain inhibition induces random migration in TNF-alpha stimulated cells and prevents the generation of reactive oxygen species , but does not alter *mediated* activation of p38 [MAPK] and ERK MAPK . Positive_regulation MAPK8 TNF 20231691 2237864 TNF-alpha treatment resulted in the phosphorylation of p38 MAPK and its downstream target , MAPK activated protein kinase-2 , but IFN-gamma did not affect the levels of [MAPK] and MAPK activated protein kinase-2 phosphorylation *induced* by . Positive_regulation MAPK8 TNF 20333651 2266141 On the other hand , *stimulated* the phosphorylation of c-Src , EGFR , Akt , [JNK1/2] , and c-Jun , which were inhibited by pretreatment with Gö6983 . Positive_regulation MAPK8 TNF 20404936 2246120 Given the known function of GADD45B as a factor that represses Mitogen activated protein Kinase Kinase 7 - c-Jun N-terminal Kinase ( MKK7-JNK ) pathway mediated apoptosis , we have now demonstrated that CAR interacts with GADD45B to repress *induced* [JNK1] phosphorylation as well as cell death . Positive_regulation MAPK8 TNF 20463356 2301066 By Western blot analysis , we found that rapidly and significantly *increased* phosphorylation of IKBKB , MAPK1/3 , and [MAPK8/9/10] and that the phosphorylation of these kinases by TNF was reduced significantly by TNFRSF1A neutralizing antibody , but not by TNFRSF1B neutralizing antibody . Positive_regulation MAPK8 TNF 20489729 2327426 induced *activation* of p38 [MAPK] and the production of inducible nitric oxide synthase were suppressed in ASK1-deficient Müller glial cells . Positive_regulation MAPK8 TNF 20522023 2295345 For instance , all morbidly obese patients , irrespective of their insulin resistance , showed increased expression of ( tumour necrosis factor alpha ) and *activation* of [JNK1/2] ( c-Jun N-terminal kinase 1/2 ) . Positive_regulation MAPK8 TNF 20646342 2292555 Effects of budesonide on P38 [MAPK] activation , apoptosis and IL-8 secretion , *induced* by and Haemophilus influenzae in human bronchial epithelial cells . Positive_regulation MAPK8 TNF 20646342 2292583 *induced* a significant increase in p38 [MAPK] phosphorylation . Positive_regulation MAPK8 TNF 20693316 2351484 In four of the six donors , basal and *induced* ERK and p38 [MAPK] activation were higher in ASMA than ASMNA cells . Positive_regulation MAPK8 TNF 20696856 2351515 Surprisingly , replenishment with exogenous GSH normalizes both *dependent* NF-?B as well as [MAPK] signaling and rescues hepatocytes from FKB induced death . Positive_regulation MAPK8 TNF 20951126 2364974 Taken together , this study provided first evidence demonstrating that TRAIL- , , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK8 TNF 21123734 2377728 The ability of CO to inhibit *induced* ERK1/2 and p38 [MAPK] activities in an Akt dependent manner appears to be the key element in ROS dependent survival of endothelial cells during TNF-a mediated brain inflammatory disease . Positive_regulation MAPK8 TNF 21181166 2499621 IL-1ß and *activated* the intracellular mitogen activated protein kinases ( MAPKs ) : p44/42 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) as well as nuclear factor-?B ( NF-?B ) in osteoblasts . Positive_regulation MAPK8 TNF 21285293 2425736 Inhibitors of NADPH oxidase and/or p47phox siRNA diminished ROS production and COX-2 expression as well as phosphorylation of p38 [mitogen activated protein kinase] ( p38MAPK ) and Akt *mediated* either by AS serum or by . Positive_regulation MAPK8 TNF 21336587 2457995 Effects of preconditioning with sevoflurane on induced permeability and *activation* of p38 [MAPK] in rat pulmonary microvascular endothelial cells . Positive_regulation MAPK8 TNF 21350193 2420598 stimulated a transient phosphorylation of JNK1/2 and ERK1/2 at 15 min , which returned to basal by 60 min and remained low for 4 h. CPT increased JNK1/2 activity between 3 and 4 h . TNF + CPT *caused* a sustained and robust [JNK1/2] and ERK1/2 phosphorylation by 2 h , which remained high at 4 h , suggesting involvement of MEKK4/7 and MEK1 , respectively . Positive_regulation MAPK8 TNF 21422246 2416774 Interestingly , all PHA-L ( high ) DCs displayed a strongly reduced responsiveness to *induced* [p38-MAPK] activation compared with PHA-L ( low ) DCs , indicating differences in PHA-L binding capacities between DCs with different inflammatory properties . Positive_regulation MAPK8 TNF 21422246 2416788 Moreover , hybrid-type , but not complex-type , N-glycans are required for induced [p38-MAPK] *activation* and subsequent phenotypic maturation of BMDCs ( MHC-II , CD86 , CCR7 upregulation ) . Positive_regulation MAPK8 TNF 21520062 2423127 Here , we report that *induced* cPLA(2) protein and mRNA expression , PGE ( 2 ) production , and phosphorylation of p42/p44 MAPK , p38 [MAPK] , and JNK1/2 , which were attenuated by pretreatment with a ROS scavenger [ N-acetyl-L-cysteine , ( NAC ) ] and the inhibitors of NADPH oxidase [ apocynin (APO) and diphenyleneiodonium chloride ( DPI ) ] , MEK1/2 ( U0126 ) , p38 MAPK ( SB202190 ) , and JNK1/2 ( SP600125 ) or transfection with siRNA of Nox2 , p47(phox) , MEK1 , p42 , p38 , or JNK2 . Positive_regulation MAPK8 TNF 21545687 2554386 significantly *induced* phosphorylation of p38 [MAPK] , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation MAPK8 TNF 21894146 2510888 Vehicle and untreated NTN exhibited heavy proteinuria and glomerular thrombosis at 24 h with P-selectin and fibrin immunostaining within capillaries , glomerular macrophage and T cell infiltration , *activation* of JNK and p38 [MAPK] signalling , and upregulation of glomerular mRNA levels of pro-inflammatory molecules ( , NOS2 , MMP-12 and CCL2 ) . Positive_regulation MAPK8 TNF 22002864 2526333 These results suggest that H ( 2 ) O ( 2 ) -induced secretion of *increases* apoptosis of cardiac myocytes through ROS dependent activation of p38 [MAPK] . Positive_regulation MAPK8 TNF 22184250 2537200 Replacement of Lysine 388 and Lysine 472 by arginines generates a nondegradable Miz1 mutant , which significantly suppresses *induced* [JNK1] activation and inflammation . Positive_regulation MAPK8 TNF 22227193 2544582 Casuarinin significantly inhibited induced *activation* of NF-?B , STAT1 , and p38 [MAPK] . Positive_regulation MAPK8 TNF 22230399 2519482 KMUP-1 inhibited *induced* iNOS and U46619 induced PDE-5A and phospho-p38 [MAPK] in normoxia , confirming its anti-proinflammatory action . Positive_regulation MAPK8 TNF 22250084 2551217 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Positive_regulation MAPK8 TNF 22343222 2617832 Using immunohistological techniques , we showed a higher epithelial expression of , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator [protein-1/mitogen activated protein kinase] signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation MAPK8 TNF 22525504 2522578 *up-regulated* the phosphorylation levels of p38 [MAPK] and increased the translocation of NF-kB p65 protein into the nucleus , also proved by immunofluorescence staining . Positive_regulation MAPK8 TNF 22526394 2595919 also *increased* the production of inducible nitric oxide synthase (iNOS) , nitric oxide ( NO ) , and intercellular adhesion molecule 1 ( ICAM-1 ) through activation of p38 [mitogen activated protein kinase (MAPK)] from HT-29 cells . Positive_regulation MAPK8 TNF 22773691 2659908 *induced* activation of p38 [MAPK] and NF-?B was attenuated by miR-140-3p mimic . Positive_regulation MAPK8 TNF 22819264 2646101 CORM-2 inhibited induced *activation* of p38 [MAPK] , ERK1/2 , JNK , and NF-?B signaling pathways in HUVECs . Positive_regulation MAPK8 TNF 22947346 2678667 *induced* phosphorylated p38 [mitogen activated protein kinase] levels were increased in ASMCs from patients with severe asthma compared with those from patients with nonsevere asthma and nonasthmatic subjects , whereas TNF-a induced phosphorylated c-Jun N-terminal kinase and phosphorylated extracellular signal related kinase levels were increased in all asthmatic groups . Positive_regulation MAPK8 TNF 22988345 2674361 The EGF receptor and HER2 participate in dependent [MAPK] *activation* and IL-8 secretion in intestinal epithelial cells . Positive_regulation MAPK8 TNF 22988345 2674389 As the epidermal growth factor receptor (EGFR) is a known transducer of proliferative signals and a potent activator of MAPKs , we hypothesized that the EGFR participates in *dependent* [MAPK] activation and IL-8 secretion by intestinal epithelial cells ( IECs ) . Positive_regulation MAPK8 TNF 23071098 2720917 Mixed-effects modeling analysis of our data was vital for ascertaining that IL-1a and TGF-a treatment increased the activities of more pathways than IL-6 and TNF-a and that TGF-a and *increased* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phospho-protein levels in a synergistic manner . Positive_regulation MAPK8 TNF 23142559 2722792 Western blot analysis revealed that pilocarpine and physostigmine enhanced the *induced* phosphorylation of ERK1/2 and p38 [MAPK] and the degradation of I?Ba . Positive_regulation MAPK8 TNF 23333920 2758390 Interestingly , IL-27 promoted the basal and enhanced *induced* phosphorylation of p38 [MAPK] and Akt , but not I?Ba . Positive_regulation MAPK8 TNF 23353699 2754246 We further demonstrated that markedly *stimulated* p38 [MAPK] , p42/p44 MAPK , and JNK1/2 phosphorylation via a c-Src/EGFR , PDGFR/PI3K/Akt pathway . Positive_regulation MAPK8 TNF 23354775 2770611 p38a [mitogen activated protein kinases (MAPK)] may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , , interleukin-1ß , and oxidative stress . Positive_regulation MAPK8 TNF 23664593 2838389 sFGL2 secretion by CD4 ( + ) T cells can be *induced* with and IFN-? stimulation through [MAPK] signaling in renal allograft AR . Positive_regulation MAPK8 TNF 23816567 2861005 The phosphorylation was observed in kinase assay with purified S6K as a substrate , and in cells after [JNK1] *activation* by or MEKK1 expression . Positive_regulation MAPK8 TNF 23861542 2817263 ROCK1 dependent release of myosin was necessary for the dependent recruitment of TRAF2 to p75 and for p75-specific *activation* of NF-?B and [MAPK] signaling . Positive_regulation MAPK8 TNF 23884101 2821474 Furthermore , P. vulgaris extract suppressed *induced* phosphorylation of p38 [mitogen activated protein kinase (MAPK)] and extracellular signal regulated kinase ( ERK ) . Positive_regulation MAPK8 TNF 23935096 2840777 In contrast , loss of SK1 prevented *induced* phosphorylation of p38 [MAPK] , and inhibition of p38 MAPK , like SK1 knockdown , also potentiates RANTES induction . Positive_regulation MAPK8 TNF 24037783 2885403 Treatment of cultured spinal astrocytes with isoproterenol ( a ß-adrenergic receptor agonist ; 1 µM ) reduced both *induced* [JNK1] phosphorylation , as observed by Western blotting , and the subsequent increase of both CCL2 mRNA expression and CCL2 production , which were measured by real time-PCR and ELISA , respectively . Positive_regulation MAPK8 TNF 24037783 2885404 The *induced* [JNK1] phosphorylation was significantly blocked by treatment with GSK-3ß inhibitors ( either LiCl or TWS119 ) , and stimulation of ß-adrenergic receptors induced the inhibition of GSK-3ß through the phosphorylation of Ser ( 9 ) . Positive_regulation MAPK8 TNF 24069158 2846999 We showed that markedly *stimulated* p42/p44 MAPK , p38 [MAPK] , and JNK1/2 phosphorylation which were attenuated by their respective inhibitors . Positive_regulation MAPK8 TNF 24080497 2902545 Consistently , DUSP1 promotes apoptosis and decreases NF-?B activity in cells in which p38 [MAPK] is *induced* by treatment . Positive_regulation MAPK8 TNF 24089494 2848156 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed receptor 1 and *requires* activation of p38 [MAPK] , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation MAPK8 TNF 24361597 2911251 We further demonstrated that *stimulated* ERK1/2 , p38 [MAPK] , and JNK1/2 phosphorylation via a c-Src dependent PDGFR/PI3K/Akt pathway . Positive_regulation MAPK8 TNF 24378531 2911779 TRAF2 has been previously reported to be required for *induced* activation of p38 [MAPK] . Positive_regulation MAPK8 TNF 24441870 2922939 We showed that markedly *stimulated* Jak2 , PDGFR , Akt , and p42/p44 [MAPK] phosphorylation , which were attenuated by their respective inhibitors . Positive_regulation MAPK8 TNF 24441870 2922957 In addition , *induced* p42/p44 [MAPK] phosphorylation was reduced by AG1296 or LY294002 . Positive_regulation MAPK8 TNF 24441870 2922993 On the other hand , could *induce* Akt and p42/p44 [MAPK] translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation MAPK8 TNF 24446489 2912944 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Positive_regulation MAPK8 TNF 24489443 2884798 Finally , by investigating the intracellular pathways involved in promoting the VEC release of cytokines/chemokines , which are targeted by natural anti-inflammatory compounds , we documented that aLipoic acid significantly counteracted *induced* NF-?B and [p38/MAPK] activation while the effects of Ginkgo biloba appeared to be predominantly mediated by Akt . Positive_regulation MAPK8 TNF 24750790 2936587 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas and NO production *required* all three [MAPK] . Positive_regulation MAPK8 TNF 7689564 225770 *induced* activation and increased tyrosine phosphorylation of [mitogen activated protein (MAP) kinase] in human fibroblasts . Positive_regulation MAPK8 TNF 7689564 225783 induced *activation* of [MAPK] was demonstrated by its enhanced ability to phosphorylate myelin basic protein in vitro and by a characteristic shift in the electrophoretic mobility of MAPK proteins . Positive_regulation MAPK8 TNF 7722327 301763 *induces* tyrosine phosphorylation of [mitogen activated protein kinase] in adherent human neutrophils . Positive_regulation MAPK8 TNF 7722327 301789 PMN pretreatment with genistein , a tyrosine kinase inhibitor , inhibited the *induced* increase in tyrosine phosphorylation and [MAPK] activity . Positive_regulation MAPK8 TNF 7929360 274500 Furthermore , an immune complex kinase assay specifically demonstrates that *stimulates* the activity of [JNK1] , the recently described predominant form of JNK . Positive_regulation MAPK8 TNF 8626494 360282 Inhibition of *induced* p42/p44 [mitogen activated protein kinase] activation by sodium salicylate . Positive_regulation MAPK8 TNF 8626494 360296 *activates* both p42 and p44 [mitogen activated protein kinases (MAPK)] in human FS-4 fibroblasts , cells for which TNF is mitogenic . Positive_regulation MAPK8 TNF 8626494 360309 We now show that *activates* p42 [MAPK] in two cell lines whose growth is inhibited by TNF . Positive_regulation MAPK8 TNF 8626494 360324 We now show that neither phorbol ester-sensitive protein kinase C nor Gialpha link TNF to p42/p44 MAPK activation , because pretreatment of FS-4 cells with phorbol ester to down-regulate protein kinase C or pretreatment with pertussis toxin to block Gialpha does not inhibit p42/p44 [MAPK] *activation* by . Positive_regulation MAPK8 TNF 8626494 360352 To further analyze MAPK activation in FS-4 cells , we compared p42/p44 [MAPK] *activation* by and epidermal growth factor (EGF) . Positive_regulation MAPK8 TNF 8626494 360369 Elucidation of the mechanism whereby sodium salicylate blocks induced p42/p44 [MAPK] *activation* may help to clarify TNF activated signaling pathways . Positive_regulation MAPK8 TNF 8662702 367188 additionally *caused* rapid p38 and JNK-1 [mitogen activated protein kinase] activation and efficient NF-kappaB translocation , which could not be achieved even by high levels of ceramide . Positive_regulation MAPK8 TNF 9006914 410775 stimulation of endothelial cells induces transient phosphorylation of both ATF-2 and c-JUN and *induces* marked activation of the c-JUN N-terminal kinase ( [JNK1] ) and p38 but not extracellular signal regulated kinase ( ERK1 ) . Positive_regulation MAPK8 TNF 9106254 424425 The increases in [MAPK] *induced* by and IL-1 were similar to the increases induced by PMA and PDGF-AB . Positive_regulation MAPK8 TNF 9106254 424451 Our findings indicate that and IL-1 activate parallel signal transduction pathways in human neuroma fibroblasts , and that they are relatively stronger *activators* of [MAPK] than of SAPK . Positive_regulation MAPK8 TNF 9315666 456106 , an inhibitor of insulin stimulated adipogenesis , *activated* [MAPK] in 3T3-L1 cells . Positive_regulation MAPK8 TNF 9439626 482875 *increased* ERK1 and ERK2 [MAPK] phosphorylation . Positive_regulation MAPK8 TNF 9439626 482901 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic effect of *requires* protein tyrosine phosphorylation and [MAPK] activation . Positive_regulation MAPK8 TNF 9593119 505491 The CAZ released endotoxin was similar to purified LPS with respect to the following biological activities in LPS-responsive C3H/HeN mice and LPS-hyporesponsive C3H/HeJ mice : lethal toxicity in GalN sensitized mice , in vitro induction of and NO production by macrophages , and [mitogen activated protein kinase] *activation* in macrophages . Positive_regulation MAPK8 TNF 9756505 535761 The proinflammatory cytokine *stimulated* [JNK1] but had no effect on extracellular signal regulated kinase ( ERK2 ) induction , suggesting that activation of JNK1 might represent an important event in mediation of the inflammatory response in the stomach . Positive_regulation MAPK8 TNF 9766635 538520 Our data suggest that and GM-CSF *activate* ERKs and p38 [MAPK] by different signal transduction pathways . Positive_regulation MAPK8 TNF 9770326 538808 Furthermore , *induction* of p42/p44 ERK and [p38-MAPK] phosphorylation , c-jun kinase activation , and IkappaBalpha degradation were normal . Positive_regulation MAPK8 TNF 9883899 558214 *Activation* of p42/p44 [mitogen activated protein kinases (MAPK)] and p38 MAPK by is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation MAPK8 TNF 9883899 558229 Here , we demonstrate that is *sufficient* to activate p42/p44 [MAPK] and p38 MAPK . Positive_regulation MAPK8 TNF 9930718 588843 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Positive_regulation MAPK8 TNF 9931102 588910 ( 100 U/mL ) transiently *activated* [MAPK] with a maximal induction 10 minutes after stimulation that returned to baseline levels by 2 hours after treatment . Positive_regulation MAPK8 TNF 9931102 588923 PD98059 also blocked *stimulated* [MAPK] activation in a concentration dependent manner , which is consistent with its inhibition of TNF-alpha directed migration . Positive_regulation MAPK8 TNF 9931102 588936 To identify which TNF-alpha receptor is involved in *induced* [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Positive_regulation MAPK8 TNF 9931102 588962 VSMC express both receptors , but *induced* [MAPK] activation was inhibited only by the TNF-R1 antibody . Positive_regulation MAPK8 TNF 9931102 588988 Both TRO and RSG inhibited migration , but neither attenuated induced [MAPK] *activation* , indicating that their antimigration activity was exerted downstream of MAPK . Positive_regulation MAPK8 TNFSF10 12969966 1185577 Among the intracellular pathways investigated , significantly *stimulated* the extracellular signal regulated kinase 1/2 ( ERK1/2 ) but not the [p38/mitogen activated protein kinase (MAPK)] or the c-Jun NH2-terminal kinase (JNK) pathway . Positive_regulation MAPK8 TNFSF10 20951126 2364975 Taken together , this study provided first evidence demonstrating that , TNF-a- , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK8 TNFSF10 21152872 2373399 Taken together , we show herein that the upstream molecule of the *induced* [MAPK] activation is MEKK , as opposed to ASK1 , via the mediation of its signal through JNK/p38 in a caspase-8 dependent manner . Positive_regulation MAPK8 TNFSF10 22435755 2594478 IFN-a induced [JNK1] *activation* via PKC-d , leading to upregulation of . Positive_regulation MAPK8 TNFSF10 23051914 2703105 Knockdown of TRAF2 or RIPK1 effectively suppressed *induced* [MAPK8] activation and autophagy . Positive_regulation MAPK9 ADRB2 11018034 752796 *induced* p38 [MAPK] activation is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes . Positive_regulation MAPK9 ADRB2 12509508 1038754 beta-Arrestin 1 is required for internalization and [mitogen activated protein (MAP) kinase] *activation* by the . Positive_regulation MAPK9 ADRB2 19047375 2023490 Hematopoietic protein tyrosine phosphatase mediates *induced* regulation of p38 [mitogen activated protein kinase] in B lymphocytes . Positive_regulation MAPK9 ADRB2 9038193 415371 In the present work , we report that stimulation of the A2A-adenosine receptor and of the *activates* [mitogen activated protein kinase] ( MAP kinase ) in human endothelial cells based on the following criteria : adenosine analogues and beta-adrenergic agonists cause an ( i ) increase in tyrosine phosphorylation of the p42 isoform and to a lesser extent of the p44 isoform of MAP kinase and ( ii ) stimulate the phosphorylation of myelin basic protein by MAP kinase; (iii) this is accompanied by a redistribution of the enzyme to the perinuclear region . Positive_regulation MAPK9 ADRB2 9363896 462914 We show that in HEK293 cells , *stimulation* of [mitogen activated protein (MAP) kinase] by the is mediated by the betagamma subunits of pertussis-toxin-sensitive G proteins through a pathway involving the non-receptor tyrosine kinase c-Src and the G protein Ras . Positive_regulation MAPK9 ALOX5 11807011 903514 In contrast , stress induced product formation and translocation of <5-LO> , as well as *activation* of p38 [MAPK] , occurred also after Ca ( ++ ) depletion . Positive_regulation MAPK9 ALOX5 21200133 2391700 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Positive_regulation MAPK9 ANGPT1 12039842 954287 Accordingly , ephrinB2 inhibited VEGF- and *induced* [Ras-MAPK] activities , whereas ephrinB2 did not alter VEGF induced Flk phosphorylation or Ang1 induced Tie2 phosphorylation . Positive_regulation MAPK9 ANGPT1 12213710 985655 Both VEGF and *induced* rapid , monophasic ( 15 minutes ) phosphorylation of p38 [MAPK] . Positive_regulation MAPK9 ANGPT1 12213726 985725 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of and Ang-2 as well as the *activation* of [MAPK] , SAPK/JNK , and p38 by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation MAPK9 ANGPT1 16061664 1439075 *activated* [mitogen activated protein kinase (MAPK)] and phosphoinositide 3-kinase (PI3K) in IBE cells and HUVECs . Positive_regulation MAPK9 ANGPT1 16679392 1612159 Pretreatment with either DPI or apocynin also significantly attenuated *induced* Akt and p44/42 [MAPK] phosphorylation . Positive_regulation MAPK9 ANGPT1 16679392 1612175 Using mouse heart microvascular endothelial cells from wild-type ( WT ) mice and mice deficient in the p47(phox) component of NADPH oxidase ( p47 ( phox-/- ) ) , we found that although *stimulated* intracellular ROS , Akt and p42/44 [MAPK] phosphorylation , and cell migration in WT cells , the responses were strikingly suppressed in cells from the p47 ( phox-/- ) mice . Positive_regulation MAPK9 ANGPT1 20072135 2235293 *promoted* skin cell metabolism/viability , adhesion , and akt and [MAPK] ( p42/44 ) activations . Positive_regulation MAPK9 ANO1 22564524 2619168 *induces* [MAPK] and contributes directly to tumorigenesis and cancer progression . Positive_regulation MAPK9 CAPN8 21543591 2424201 Downstream , an Aß-mediated rise in p38 [mitogen activated protein kinase (MAPK)] activation was followed by downregulation of cAMP response element binding protein , and LTP impairment was *prevented* by inhibitors of p38 MAPK or . Positive_regulation MAPK9 CAPN8 24416390 2901069 Treatment with glutamate leads to early activation of NMDAR , which in turn leads to mediated cleavage of striatal enriched protein tyrosine phosphatase ( STEP ) and subsequent *activation* of p38 [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK9 CCL17 23711854 2792915 IL-33 induced the production of thymus and activation regulated and macrophage derived chemokine/CCL22 and the *activation* of extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase and p38 [MAPK] . Positive_regulation MAPK9 CCND1 11004713 735028 FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ) , b ) transcription activation of c-fos , c-jun and c-myc genes ( 10 to 30 min ) , c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h. ACTH , itself a weak mitogen , interacts with FGF2 in a complex manner , blocking the FGF2 mitogenic response during the early and middle G1 phase , keeping [ERK-MAPK] activation and c-Fos and *induction* at maximal levels , but post-transcriptionally inhibiting c-Myc expression . Positive_regulation MAPK9 CCND1 12654183 1072990 [MAPK] may *induce* overexpression of protein and results in persistent proliferation of RS/H cells in genesis and development of HL . Positive_regulation MAPK9 CCND1 15634644 1349560 Flavopiridol/HA14-1 treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase , a modest *activation* of p38 [mitogen activated protein kinase] , and down-regulation of . Positive_regulation MAPK9 CCND1 16522728 1531464 We conclude that incretin induced beta-cell replication is dependent on cAMP/PKA , p42 [MAPK] and PI3K activities , which may *involve* transcriptional induction of . Positive_regulation MAPK9 CCND1 9537433 497572 Furthermore , in 25 of 26 cases of HCC which genomic DNA was available , 22 cases without genomic DNA amplification exhibited positive correlation , not only between protein expression of c-Fos and , but also between [MAPK/ERK] *activation* and cyclin D1 expression . Positive_regulation MAPK9 CD14 15625444 1349243 LPS interacts with the cell surface receptor , which generates transmembrane signals through Toll-like protein 4 *leading* to [mitogen activated protein kinase (MAPK)] p38 activation , cytokine synthesis , PMN beta2-integrin expression and oxidative burst . Positive_regulation MAPK9 CHI3L1 23755018 2797734 In addition , *induces* [FAK-MAPK] signaling and up-regulates VEGF receptor 2 in endothelial cells ; Positive_regulation MAPK9 CHI3L1 23972995 2836246 We also demonstrate that *activates* macrophage [mitogen activated protein kinase] , protein kinase B/AKT , and Wnt/ß-catenin signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation MAPK9 CLU 23051594 2702833 FOXL2 directly stimulates the Clu gene promoter , and we show that PTTG triggers ataxia telangiectasia mutated [kinase/IGF-I/p38MAPK] DNA damage/chromosomal instability signaling , which in turn also *induces* expression . Positive_regulation MAPK9 CTGF 11732999 885269 *induces* chondrocyte differentiation through a p38 [mitogen activated protein kinase] ( p38MAPK ) , and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase ( ERK ) . Positive_regulation MAPK9 CTGF 11732999 885283 In the proliferation phase , *induced* a approximately fivefold increase in the phosphorylation of p44/42 [MAPK/ERK] and a approximately twofold increase in that of p38 MAPK in an in vivo kinase assay . Positive_regulation MAPK9 CTGF 12218048 1012169 The inhibition of *induced* p42/44 [MAPK] or phosphatidylinositol 3-kinase (PI3K)/protein kinase B pathway activities abrogated the induction of fibronectin expression . Positive_regulation MAPK9 CTGF 16408113 1513484 *enhanced* the mRNA expression and protein release of fractalkine , MCP-1 , and RANTES , the expression of phospho ( P ) -p42/44 [mitogen activated protein kinase (MAPK)] , P-phosphoinositide 3-kinase (PI3-K) , P-Akt , and activity of nuclear factor-kappaB (NF-kappaB) in mesangial cells . Positive_regulation MAPK9 CTGF 16408113 1513526 P-p42/44 MAPK blockade inhibited the *induced* expression of P-p42/44 [MAPK] but not NF-kappaB , and partially decreased the levels of the above chemokines in supernatants . Positive_regulation MAPK9 CTGF 16522717 1531332 ( 3 ) *stimulated* dose dependent HSC adhesion and activity of p42/p44 [mitogen activated protein kinase] , the latter of which was antagonized by blocking the activity of focal adhesion kinase . Positive_regulation MAPK9 CTGF 16938382 1654131 No single module , but a mixture of the 4 modules provoked a significant activation of p38 [MAPK] in HCS-2/8 cells , which was *activated* by the full-length . Positive_regulation MAPK9 CTGF 19038999 2023097 Interestingly , CCN2-BMP-2 did not affect the *induced* phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Positive_regulation MAPK9 EDN2 12193071 980952 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Positive_regulation MAPK9 EDN2 12475899 1037790 *induced* a rapid phosphorylation of the [mitogen activated protein kinase (MAPK)/ERK] and increased collagen I gene activity in freshly isolated aortas . Positive_regulation MAPK9 EDN2 1280103 203057 rapidly *stimulates* [mitogen activated protein kinase] activity in rat mesangial cells . Positive_regulation MAPK9 EDN2 12855582 1149908 also *induced* the activation of p42/44 [mitogen activated protein kinase (MAPK)] in DCs . Positive_regulation MAPK9 EDN2 7509933 241624 *stimulates* [mitogen activated protein kinase] p42 activity through the phosphorylation of the kinase in rat mesangial cells . Positive_regulation MAPK9 EDN2 7849246 286748 *stimulates* [mitogen activated protein kinase] activity in mesangial cells through ETA . Positive_regulation MAPK9 EDN2 7943276 276415 has been shown to *activate* [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK9 EDN2 8836145 386189 In bovine airway smooth-muscle cells platelet derived growth factor ( PDGF ) and ( Et-1 ) *stimulate* sustained and comparable activation of [mitogen activated protein kinase] ( MAP kinase ) but display very different mitogenic efficacies , with PDGF inducing 50 times more DNA synthesis than Et-1 . Positive_regulation MAPK9 EFNB1 15502157 1347567 Further downstream of the signaling pathway , stimulation *led* to increased LAT ( linker for activation of T-cells ) phosphorylation and p44/42 and p38 [MAPK] activation . Positive_regulation MAPK9 EPHB2 10601128 574225 Tumor necrosis factor-alpha (TNF-alpha) alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only . Positive_regulation MAPK9 EPHB2 10872747 707032 Pre-treatment of the cells with PD98059 , a selective pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation MAPK9 EPHB2 11083274 750498 Tumor necrosis factor alpha , interleukin-1 (IL-1) , and IL-6 were the major inducers of , JNK , and p38 [MAPK] *activation* in cultured human synovial cells . Positive_regulation MAPK9 EPHB2 12386816 999770 Pro-apoptotic concentrations of Aplidin induce early oxidative stress , which results in a rapid and persistent activation of both JNK and p38 [MAPK] and a biphasic *activation* of . Positive_regulation MAPK9 EPHB2 12403788 1036193 SB203580 , a p38 [MAPK] *inhibitor* , and PD98059 , an inhibitor , but not wortmannin a phosphatidylinositol 3-kinase (PI3K) inhibitor , prevented AA toxicity in pyrazole hepatocytes and E47 cells . Positive_regulation MAPK9 EPHB2 12486127 1056315 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain *had* little effect on basal Erk [MAPK] activation . Positive_regulation MAPK9 EPHB2 12511425 1070744 Contact with C albicans triggered [MAPK/ERK] activation in PMNs within 5 minutes , and blocking of activation , either by the pharmacologic reagent PD098059 or by dominant negative MAPK kinase ( MEK ) expression via vaccinia viral delivery , *suppressed* antimicrobial activity . Positive_regulation MAPK9 EPHB2 12801927 1120239 GE2 stimulation *induced* phosphorylation , whereas it did not alter the phosphorylation of c-Jun N-terminal kinase or p38 [MAPK] . Positive_regulation MAPK9 EPHB2 12832293 1105584 Exposure to E. coli DNA resulted in phosphorylation of ERK 1/2 [MAPK] and inhibitors of activity ( PD98059 , UO126 ) significantly *reduced* the evoked IL-8 production . Positive_regulation MAPK9 EPHB2 12878192 1115526 ( 2 ) the *activation* of JNK and p38 [MAPK] but not in embryonic fibroblasts ( MEFs ) derived from ASK1 knockout mice ( ASK1 ( -/- ) MEFs ) was depressed compared to MEFs derived from wild type mice ( ASK1 ( +/+ ) MEFs ) ; Positive_regulation MAPK9 EPHB2 14973553 1212801 Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of [ERK/mitogen activated protein kinase (MAPK)] signaling *mediated* by fibroblast growth factor ( FGF-2 ) and both and Akt signaling mediated by hepatocyte growth factor (HGF) . Positive_regulation MAPK9 EPHB2 14998726 1216737 Furthermore , we found that PD98059 , an pathway inhibitor , and SB203580 , a p38 [MAPK] *inhibitor* , diminished AAPH induced COX-2 expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation MAPK9 EPHB2 15659876 1350321 The anabolic effect of TNF-alpha was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an . Positive_regulation MAPK9 EPHB2 16038626 1437443 SF significantly prevented Abeta induced increases in IL-1beta and p38 [MAPK] *activation* and also Abeta induced changes in and phospho-Akt/PKB expression levels . Positive_regulation MAPK9 EPHB2 17056059 1649534 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Positive_regulation MAPK9 EPHB2 17403539 1735941 Trauma-hemorrhage increased the production of IL-6 , IL-10 , IL-12 and TNF-alpha enhanced the expression of TLR4 , MyD88 as well as the *activation* of [MAPK] proteins ( p38 , and JNK ) in epidermal keratinocytes . Positive_regulation MAPK9 EPHB2 17416211 1777935 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK9 EPHB2 17464174 1731752 The mRNA and surface protein up-regulation of CCR1 and CCR2 in 9CRA stimulated cells were weakly blocked by the pretreatment of SB202190 , a p38 [MAPK] *inhibitor* , and PD98059 , an upstream inhibitor . Positive_regulation MAPK9 EPHB2 18164124 1869617 Adipocyte culture medium- and palmitate induced MIC-1 gene expression was mediated by the activation of p38 [MAPK] , but not by the *activation* of JNK , , and NF-kappaB pathway . Positive_regulation MAPK9 EPHB2 18266967 2000326 VEGF induced activation of p42 also *led* to the nuclear translocation of [MAPK/ERK1/2] . Positive_regulation MAPK9 EPHB2 18285354 1885413 Pre-treatment with the [MAPK] *inhibitors* SP600125 ( JNK inhibitor ) , SB202190 ( p38 inhibitor ) or PD98059 ( inhibitor ) significantly inhibited AGE-BSA induction of COX-2 expression and production of PGE ( 2 ) . Positive_regulation MAPK9 EPHB2 18338254 1938065 Interestingly , inhibition of by U0126 completely *prevented* artepillin C-induced p38 [MAPK] phosphorylation of PC12m3 cells . Positive_regulation MAPK9 EPHB2 18520049 1918680 These results suggest that the induction phase and early maintenance phase , but not the late maintenance phase of long lasting allodynia is mediated by the activation of , rather than by the *activation* of p38 [MAPK] , in the spinal cord . Positive_regulation MAPK9 EPHB2 18982426 2105754 These inhibitory effects were partially inhibited by SB203580 , a specific *inhibitor* of p38 [MAPK] , but not by PD98059 , a specific inhibitors of extracellular signal regulated kinase ( ) , and SP600125 , a specific inhibitor of c-Jun-N-terminal kinase (JNK) . Positive_regulation MAPK9 EPHB2 19189219 2113969 Moreover , EM1 treatment resulted in less activation of p38 [MAPK] and more *activation* of signaling in lipopolysaccharide stimulated DCs . Positive_regulation MAPK9 EPHB2 19276187 2051425 Treatment of cells with sphingosine induced suppression of and *activation* of p38 [MAPK] . Positive_regulation MAPK9 EPHB2 19429670 2106928 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either inhibitor , [p38MAPK] *inhibitor* or NF-kappaB inhibitor . Positive_regulation MAPK9 EPHB2 19522739 2103148 Treatment with [MAPK] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that melatonin induced apoptosis was JNK- and p38 dependent , but ERK independent . Positive_regulation MAPK9 EPHB2 19672126 2168081 A scratch wound assay of healing rates in SV40 immortalized human corneal epithelial cell line ( HCEC ) evaluated the relative contributions by p38 and and JNK [MAPK] signaling *activation* to wound healing . Positive_regulation MAPK9 EPHB2 20025124 2175520 Prior treatment of the cells with PD98059 , an kinase inhibitor or SB203580 , a [p38MAPK] *inhibitor* , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation MAPK9 EPHB2 20554538 2327629 The HNE enhanced Sp1 and NF-?B activities were attenuated by SB203580 , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , and PD98059 , an extracellular signal regulated kinase ( ) inhibitor , respectively . Positive_regulation MAPK9 EPHB2 21126656 2355806 Both SBT and LBT upregulate MMP-2 expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 [mitogen activated protein kinase] , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by . Positive_regulation MAPK9 EPHB2 21311676 2360041 Treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB202190 ( p38 inhibitor ) , confirmed that the melatonin induced apoptosis was p21 dependent , but ERK independent . Positive_regulation MAPK9 EPHB2 21488184 2417980 Dexmedetomidine induced phosphorylation of JNK and p38 [MAPK] in rat aortic SMCs , but did not *induce* phosphorylation of . Positive_regulation MAPK9 EPHB2 21586573 2449673 Incubation of T cells with ESAT-6 induced phosphorylation and increased functional p38 [MAPK] activity , but not *activation* of or JNK . Positive_regulation MAPK9 EPHB2 21599960 2445740 In the present studies , induction of central sensitization as indicated by spinal dorsal horn [MAPK] *activation* , specifically and p38 phosphorylation , was assessed in the MIA-OA model . Positive_regulation MAPK9 EPHB2 23394443 2713250 When compared to hamsters bearing tumors that remained on the control diet , the buccal pouches of hamsters bearing tumors receiving turmeric showed the following results : ( 1 ) decreased cell proliferation ( diminished PCNA , cyclin D1 , and Bcl-2 ) and PCNA labelling index , ( 2 ) enhanced apoptosis ( increased Bax , caspase-3 , caspase-9 , and cytochrome c , and decreased survivin ) and apoptotic index , ( 3 ) decreased inflammation ( decreased Cox-2 ) , and ( 4 ) decreased [MAPK] *activation* ( and p-p38 ) . Positive_regulation MAPK9 EPHB2 23892041 2830342 Furthermore , the role of mitogen activated protein kinases (MAPK) pathways in the apoptosis induced by TF3 or EGCG together with Vc were studied using three [MAPK] *inhibitors* ( inhibitor PD98059 , JNK inhibitor SP600125 and p38 inhibitor SB203580 ) . Positive_regulation MAPK9 EPHB2 23914844 2840578 These inflammatory biomarkers were attributed to the suppression of LPS induced activation of p38 [MAPK] and subsequent *activation* of two components of AP-1 ( c-Jun and c-Fos ) , but not of , JNK , NF-?B . Positive_regulation MAPK9 EPHB2 23917355 2826055 Inhibition of Akt or activity *reduced* phosphorylation of STAT1 in Colon26L5-CUG2 cells whereas inhibition of p38 [MAPK] did not significantly decrease levels of STAT1 phosphorylation , indicating that cell proliferation signals may be involved in CUG2 mediated activation of STAT1 . Positive_regulation MAPK9 EPHB2 24225419 2897502 Therefore , by using the [MAPK] *inhibitors* SP600125 ( a specific JNK inhibitor ) and PD98059 ( a specific inhibitor ) , we have unmasked the particular MAPK that underlies the modulation of the expression levels of these PTPs . Positive_regulation MAPK9 EPHB2 24297112 2894233 Following treatment with [mitogen activated protein kinase (MAPK)] *inhibitors* , PD98059 ( inhibitor ) , SP600125 ( JNK inhibitor ) and SB203580 ( p38 inhibitor ) , the cytotoxity of oridonin was not influenced by JNK ( SP600125 ) and ERK ( PD98059 ) , but these effects were opposite to the cytotoxity of oridonin observed with SP203580 treatment . Positive_regulation MAPK9 F2R 16052512 1460032 The p38 and ERK1/2 [MAPK] signaling cascades were also *activated* by stimulation , whereas the SAPK/JNK pathway was unaffected . Positive_regulation MAPK9 F2R 16467309 1548167 and PAR-2 stimulation rapidly *activated* both ERK1/2 and [p38MAPK] , and pharmacological blockade of MEK with either PD98059 or U0126 or of p38MAPK by SB203580 or SB202190 strongly inhibited thrombin- and SLIGKV induced COX-2 expression and 6-keto-PGF1alpha formation . Positive_regulation MAPK9 F2R 21252088 2402892 In the present study , we show that FVIIa , upon binding to EPCR on endothelial cells , activates endogenous protease activated receptor-1 (PAR1) and induces mediated p44/42 [mitogen activated protein kinase (MAPK)] *activation* . Positive_regulation MAPK9 F2R 24052258 2867023 However , the distinct non-canonical tethered ligands unmasked by neutrophil elastase and proteinase-3 , as well as synthetic peptides with sequences derived from these novel exposed tethered ligands , selectively stimulated mediated [mitogen activated protein kinase] *activation* . Positive_regulation MAPK9 F2R 8635212 358024 These results support the notion that the *activates* [MAPK] through PKC dependent pathways and that the incremental activation of MAPK by TRAP over that induced by thrombin is the consequence of enhanced activation through the PKC limb of the phosphoinositide lipid pathway . Positive_regulation MAPK9 FAS 10391681 626726 ligation in the presence of cycloheximide *induced* Jun N-terminal kinase 1 (JNK1) and [JNK2] phosphorylation , caspase activation and cell death in the IL-3 dependent cell line BAF3 . Positive_regulation MAPK9 FAS 14576831 1156612 A more physiological inhibitor , the intracellular PP2A inhibitor protein I2 ( PP2A ) , protected transfected HeLa cells in a similar way from mediated apoptosis and induced *activation* of [MAPK] in I2 ( PP2A ) transfected cells . Positive_regulation MAPK9 FAS 15280387 1302539 We further demonstrate that this pro-apoptotic effect of CO was independent of reactive oxygen species production and involved inhibition in *induced* activation of the pro-survival ERK [MAPK] . Positive_regulation MAPK9 FAS 16507991 1529649 Here we show that binding of Fas ligand to *activates* p38 [MAPK] in CD8+ T cells and that activation of this pathway is required for Fas mediated CD8+ T-cell death . Positive_regulation MAPK9 FAS 19417161 2179817 GST-MDA-7 killing was , in parallel , dependent on inactivation of extracellular signal regulated kinase 1/2 and on *induced* p38 [mitogen activated protein kinase] and c-jun NH ( 2 ) -terminal kinase-1/2 signaling . Positive_regulation MAPK9 FAS 21613257 2454283 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Positive_regulation MAPK9 FAS 21975294 2492850 Caspase-8 activity has an essential role in *mediated* [MAPK] activation . Positive_regulation MAPK9 FAS 8977313 403353 IFN-alpha2 did not alter the *induced* activity of [Mitogen activated protein kinase (MAPK)] 1 and did not inhibit the Apo-1/Fas mediated proteolytic cleavage of ADP-ribosyltransferase , a substrate of Interleukin-beta1 converting enzyme ( ICE ) and homologues . Positive_regulation MAPK9 FHL1 23456229 2781824 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Positive_regulation MAPK9 FOXA1 22879989 2641689 An increase in IGFBP-3 , mediated by depletion of , *inhibited* phosphorylation of [MAPK] and Akt , and increased expression of the cell cycle regulators p21 and p27 . Positive_regulation MAPK9 FUT4 20506505 2307962 These data suggested that not only *activates* [MAPK] and PI3K/Akt signals , but also promotes the crosstalk among these signaling pathways . Positive_regulation MAPK9 GLP1R 21356521 2394822 activation by Exendin-4 ( Ex-4 ) *increased* PKA and [MAPK] activity and decreased phosphorylation of AMPK in NTS . Positive_regulation MAPK9 GPR115 10958680 726074 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK9 GPR115 11916960 945826 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK9 GPR115 9182581 436020 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on mediated *activation* of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK9 GPR115 9826186 550417 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK9 GPR132 10958680 726063 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK9 GPR132 11474113 841745 Activation of by LPC *increased* intracellular calcium concentration , induced receptor internalization , activated ERK [mitogen activated protein kinase] , and modified migratory responses of Jurkat T lymphocytes . Positive_regulation MAPK9 GPR132 11916960 945815 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK9 GPR132 9182581 436009 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on mediated *activation* of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK9 GPR132 9826186 550406 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK9 GPR87 10958680 726143 mediated [mitogen activated protein kinase] *activation* through cooperation of Galpha ( q ) and Galpha ( i ) signals . Positive_regulation MAPK9 GPR87 11916960 945895 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Positive_regulation MAPK9 GPR87 9182581 436089 Here , we investigated the functional activity of RGS3 and a truncated form of RGS3 on mediated *activation* of adenylyl cyclase , phosphoinositide phospholipase C , and [mitogen activated protein kinase] in intact cells . Positive_regulation MAPK9 GPR87 9826186 550486 Further studies indicate that Pyk2 phosphorylation , but not [MAPK] activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation MAPK9 HBEGF 10544013 563930 also rapidly *activated* [MAPK] and induced cyclin D1 in mid-G1 with kinetics similar to TGFalpha . Positive_regulation MAPK9 HBEGF 11171084 783801 Both p42 [MAPK] activation and mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation MAPK9 HBEGF 15380451 1298487 *induced* phosphorylation of ERK , p38 [MAPK] and Akt , which were suppressed by ZD1839 . Positive_regulation MAPK9 HBEGF 17928891 1858631 We report that cellular stress with methyl-beta-cyclodextrin ( MBCD ) , a molecule that extracts membrane cholesterol and thereby disrupts the structure of lipid rafts , strongly *induces* the synthesis of ( HB-EGF ) in keratinocytes through the activation of p38 [mitogen activated protein kinase] . Positive_regulation MAPK9 HBEGF 18990151 2028930 *Activation* of [Erk/MAPK] by was inhibited by APF , and APF did not stimulate p38MAPK in the presence of soluble HB-EGF or when cells overexpressed constitutively secreted HB-EGF . Positive_regulation MAPK9 HBEGF 19048624 2023723 In addition , the overexpression of in paclitaxel treated SKOV3 cells *resulted* in modulation of paclitaxel evoked [MAPK] signaling , including marked activation of ERK and Akt , and minimized activation of JNK and p38 MAPK , indicating that HB-EGF is involved in drug sensitivity through the balance of anti-apoptotic and pro-apoptotic signals induced by paclitaxel . Positive_regulation MAPK9 HBEGF 19559571 2110511 *induced* phosphorylation of p42/p44 [MAPK] in a few minutes . Positive_regulation MAPK9 HBEGF 20739666 2345896 Moreover , *induced* a stronger and more sustained activation of both the [mitogen activated protein kinase] and phosphoinositol 3 kinase ( PIK3 ) signaling pathways . Positive_regulation MAPK9 HBEGF 24188029 2921116 Here , we show that *induced* EGF receptor (EGFR) activation by Y1068 phosphorylation , [Mapk/Erk] pathway activation , and led to an increase in cell proliferation , more prominent in Bioactive3D than in 2D cultures . Positive_regulation MAPK9 HRH1 11959800 931448 1. Previous studies have shown that the *activates* p42/p44 [mitogen activated protein kinases (MAPK)] in DDT ( 1 ) MF-2 smooth muscle cells via a phosphatidylinositol 3-kinase (PI-3K) dependent pathway . Positive_regulation MAPK9 HRH1 17965772 1820346 is *required* for TCR mediated p38 [MAPK] activation and optimal IFN-gamma production in mice . Positive_regulation MAPK9 HRH1 17965772 1820360 Moreover , signaling at the time of TCR ligation was *required* for activation of p38 [MAPK] , a known regulator of IFN-gamma expression . Positive_regulation MAPK9 IFI27 16953232 1682599 RET2A mediated regulation of p18 and , but not of cyclins D1 and D2 , *requires* functional [mitogen activated protein kinase] signaling . Positive_regulation MAPK9 IL1B 10640438 577518 and TNF alpha also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK9 IL1B 10704772 673012 CPI-1189 inhibits *induced* [p38-mitogen activated protein kinase] phosphorylation : an explanation for its neuroprotective properties ? Positive_regulation MAPK9 IL1B 10775561 686651 *activated* p44/42 [MAPK] , and this activation was enhanced in the presence of N-acetyl-L-cysteine . Positive_regulation MAPK9 IL1B 10864897 705740 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK9 IL1B 10864897 705792 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by TNF-alpha and . Positive_regulation MAPK9 IL1B 10864897 705805 TNF-alpha- and *induced* [ ( 3 ) H ] -thymidine incorporation and phosphorylation of p42/p44 [MAPK] was completely inhibited by PD98059 ( an inhibitor of MEK1/2 ) , indicating that activation of MEK1/2 was required for these responses . Positive_regulation MAPK9 IL1B 10969830 728493 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Positive_regulation MAPK9 IL1B 11032891 740461 *induces* p38 [MAPK] phosphorylation and activation of the nuclear factor-kappaB independently from each other . Positive_regulation MAPK9 IL1B 11037878 741248 also *stimulated* phosphorylation of p38 [MAPK] , SAPK/JNK , and ATF-2 . Positive_regulation MAPK9 IL1B 11126408 759780 TNFalpha and IFNgamma potentiate *induced* [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK9 IL1B 11126408 759793 [Mitogen activated protein kinase (MAPK)] activity that is *induced* by has been suggested to signal nitric oxide dependent as well as nitric oxide independent beta-cell destructive pathways . Positive_regulation MAPK9 IL1B 11126408 759806 The aim of this study was to investigate if TNFalpha and IFNgamma signal through mitogen activated protein kinases in isolated rat islets of Langerhans and if they potentiate [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK9 IL1B 11126408 759819 Further , TNFalpha and IFNgamma were found to synergistically increase [mitogen activated protein kinase] activity *induced* by . Positive_regulation MAPK9 IL1B 11399523 824267 Glucose potentiates *induced* p38 [mitogen activated protein kinase] activity in rat pancreatic islets of Langerhans . Positive_regulation MAPK9 IL1B 11509550 848383 Although and TNF-alpha each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK9 IL1B 11557585 861410 *activated* the three [mitogen activated protein kinase] ( extracellular signal regulated kinases 1 and 2 , c-Jun NH2-terminal kinase/stress activated protein kinase , and p38 ) and the Janus kinase (JAK)-signal transducer and activator of transcription pathways . Positive_regulation MAPK9 IL1B 11698472 878059 *induced* phosphorylation and activation of p38 [MAPK] and phosphorylation of MAPK kinase-3/6 (MKK3/6) . Positive_regulation MAPK9 IL1B 11698472 878105 *induced* phosphorylation of ERK and JNK as well as p38 [MAPK] in human endothelial cells . Positive_regulation MAPK9 IL1B 11728947 884816 We showed a dramatic decrease in *induced* phosphorylation of p38 [MAPK] , not extracellular signal regulated kinases 1/2 or jun NH2-terminal kinase , in rat cultured mesangial cells by FR167653 . Positive_regulation MAPK9 IL1B 11775830 766444 Role of protein tyrosine kinase in *induced* activation of [mitogen activated protein kinase] in fibroblast-like synoviocytes of rheumatoid arthritis . Positive_regulation MAPK9 IL1B 11775830 766449 transiently increased protein tyrosine phosphorylation , and *activated* the MAPKs cascades ( mainly ERK2 , [JNK2] and P38 ) in RA FLS . Positive_regulation MAPK9 IL1B 11853544 913378 Interestingly , *induced* p38 [MAPK] activity was greatly enhanced in ( alg+ ) compared with ( alg- ) cells . Positive_regulation MAPK9 IL1B 12117921 964672 mRNA expression by neutrophils was not dependent on p38 MAPK , and p38 [MAPK] was not *activated* in neutrophils incubated with A. phagocytophila . Positive_regulation MAPK9 IL1B 12131776 966873 and TNF-alpha *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK9 IL1B 12139924 969403 Regarding intracellular signaling , *activated* the p38 mitogen activated protein kinase (MAPK) but not the p42/p44 [MAPK] and , when combined with growth factors , intensified p38 activation but inhibited the growth-factor induced p42/p44 activation . Positive_regulation MAPK9 IL1B 12356282 993906 induced p44/42 [mitogen activated protein kinase (MAPK)] *activation* was inhibited by the MAPK/extracellular signal regulated protein kinase ( MEK ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK9 IL1B 12417253 1012960 Sphondin ( 50 microM ) did not affect the *induced* activations of p44/42 [MAPK] , p38 MAPK , and JNK . Positive_regulation MAPK9 IL1B 12500176 1026694 These data suggest that the presence of retinal holes and may *lead* to activation of HGF , [mitogen activated protein kinases (MAPK)] , c-jun and extracellular matrix remodeling , resulting in proliferative and migratory cells in the wounded retina . Positive_regulation MAPK9 IL1B 12507586 1038428 In this study we evaluated the role of epigallocatechin-3-gallate ( EGCG ) , a green tea polyphenol which mimics its anti-inflammatory effects , in modulating the induced *activation* of [MAPK] 's in human chondrocytes . Positive_regulation MAPK9 IL1B 12649265 1080074 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant MKK6 or p38beta2 MAPK inhibited *induced* p38 [MAPK] activation , COX-2 gene expression , and PGE2 release . Positive_regulation MAPK9 IL1B 12727980 1086564 P38 [MAPK] phosphorylation was *increased* by in nondecidualized ESC , whereas the IL-1 beta induced increase was suppressed in the decidualized cells . Positive_regulation MAPK9 IL1B 12727980 1086577 Treatment with 8-bromo-cAMP reduced *induced* phosphorylation of p38 [MAPK] in nondecidualized ESC . Positive_regulation MAPK9 IL1B 12727980 1086591 In contrast , treatment with H89 , a protein kinase A inhibitor , reversed a reduction in *induced* p38 [MAPK] phosphorylation in the decidualized cells . Positive_regulation MAPK9 IL1B 12727980 1086605 The altered property of decidualized cells is thought to be caused by attenuation of *induced* p38 [MAPK] phosphorylation in a way that involves the activation of the cAMP/protein kinase A pathway . Positive_regulation MAPK9 IL1B 12882449 1116296 NAC ( 1 mM ) also decreased the induced *activation* of p38 [MAPK] . Positive_regulation MAPK9 IL1B 12952251 1137424 Using Western-blot analysis , no effect of cAMP was found on the *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK9 IL1B 12952251 1137438 No decrease was observed in *induced* p38 [mitogen activated protein kinase] , extracellular signal related kinase or cJun N-terminal kinase activation . Positive_regulation MAPK9 IL1B 14563491 1154867 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Positive_regulation MAPK9 IL1B 15039421 1251249 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of , and RIP2 dependent *activation* of NF-kappaB and p38 [MAPK] mediated by the caspase recruitment domain . Positive_regulation MAPK9 IL1B 15111866 1241246 We further demonstrated that p38 [MAPK] is *activated* by and PDGF with different kinetics and that p38 MAPK is required for maximal COX2 expression in response to IL-1beta plus PDGF-BB . Positive_regulation MAPK9 IL1B 15208668 1281350 *induced* the activation of extracellular signal regulated kinases-1/2 and P38 [mitogen activated protein kinase (MAPK)] , but not the activation of c-jun amino-terminal kinse and Akt . Positive_regulation MAPK9 IL1B 15341531 1291768 In accordance with these findings , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) , which was attenuated by U0126 , SB202190 , or SP600125 , respectively . Positive_regulation MAPK9 IL1B 15389584 1354326 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] and JNK which was attenuated by pretreatment with U0126 or SP600125 , respectively . Positive_regulation MAPK9 IL1B 15489374 1359430 Consistently , *stimulated* phosphorylation of p42/p44 [MAPK] , p38 , and JNK was attenuated by pretreatment with U0126 , SB-202190 , or SP-600125 , respectively . Positive_regulation MAPK9 IL1B 15695308 1382612 A77 1726 inhibited *induced* p38 and [c-Jun N-terminal kinase 1/2] ( JNK1/2 ) activation , whereas A77 1726 did not affect IL-1beta induced NF-kappaB activation in hepatocytes . Positive_regulation MAPK9 IL1B 15755725 1403428 The inhibitory effect of on alpha ENaC expression was *mediated* by the activation of p38 [MAPK] in both rat and human ATII cells and was independent of the activation of alpha v beta6 integrin and transforming growth factor-beta . Positive_regulation MAPK9 IL1B 16033422 1436172 Intrathecal *leads* to a time dependent up-regulation of phosphorylated p38 ( p-p38 ) [MAPK] protein expression in the spinal cord 30-240 min following IL-1beta injection ( i.t. ) . Positive_regulation MAPK9 IL1B 16033422 1436186 However , pretreatment with a p38 MAPK inhibitor significantly reduced the *induced* p-p38 [MAPK] expression by 38-49 % , and nearly completely blocked the subsequent iNOS expression ( reduction by 86.6 % ) , NO production , and thermal hyperalgesia . Positive_regulation MAPK9 IL1B 16043966 1459748 Western blot analysis demonstrated that *increased* the activation of phosphorylated MEK and p38 [MAPK] in GH3 cells . Positive_regulation MAPK9 IL1B 16140882 1450812 *induced* phosphorylation of [p38-MAPK] , but not that of c-Jun-N-terminal kinase or extracellular regulated kinase , was most susceptible to inhibition by low doses of PFE , and the addition of PFE blocked the activity of p38-MAPK in a kinase activity assay . Positive_regulation MAPK9 IL1B 16141635 1454876 DHA stimulated both rapid and prolonged activation of p44/42 , but not p38 , [mitogen activated protein kinase (MAPK)] *induced* by and PMA . Positive_regulation MAPK9 IL1B 16153910 1455451 The kidney was analyzed for expression of tumor necrosis factor alpha , , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and *activation* of p38 [mitogen activated protein kinase] , caspase 3 , and caspase 8 ( Western blot ) . Positive_regulation MAPK9 IL1B 16452991 1611751 Western blots showed that and TNF-alpha *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK9 IL1B 16528573 1549435 The aim of this study was to investigate if Gadd45b prevents *induced* beta cell [MAPK] signalling and apoptosis . Positive_regulation MAPK9 IL1B 16645161 1604684 significantly *increased* the phosphorylation of p38 [MAPK] and cPLA(2) . Positive_regulation MAPK9 IL1B 16698013 1575661 JST ( 0.01-1 mg/ml ) also attenuated the expression of cyclooxygenase (COX)-2 and activation of p38 [MAPK] *induced* by and A beta ( 1-42 ) . Positive_regulation MAPK9 IL1B 16718462 1584916 A synthetic peptide , C3d , reported to bind NCAM , did not activate MAPK or Akt as reported in neurons but inhibited *induced* [MAPK] activity , thereby mimicking the effect of SU5402 . Positive_regulation MAPK9 IL1B 16718462 1584941 We suggest that NCAM signalling through FGFR is required for efficient IL-1beta pro-apoptotic signalling by facilitating induced [MAPK] *activation* downstream of the NF-kappaB-MAPK branching point . Positive_regulation MAPK9 IL1B 16718462 1584990 Further , these data identify a novel function of C3d as an inhibitor of NCAM induced FGFR activity and of *induced* [MAPK] activation in beta cells . Positive_regulation MAPK9 IL1B 16959849 1639705 *caused* an increase in the phosphorylation of ERK , but not [p38MAPK] or c-Jun N-terminal kinase . Positive_regulation MAPK9 IL1B 16964394 1611561 Inhibitors of p38 [MAPK] and/or JNK significantly suppressed VEGF secretion both in the *presence* and absence of , while inhibitors of COX-2 , ERK1/2 , and PI3-K did not . Positive_regulation MAPK9 IL1B 17208222 1695820 Thalidomide also suppressed *induced* p38 [mitogen activated protein kinase (MAPK)] activation , while a p38 MAPK inhibitor destabilized COX-2 mRNA and the cytoplasmic shuttling of HuR induced by IL-1beta . Positive_regulation MAPK9 IL1B 17311279 1719297 *stimulated* phosphorylation of p42/p44 [MAPK] , p38 MAPK , and JNK was attenuated by pretreatment with U0126 , SB202190 , SP600125 , or transfection with these dominant negative mutants of MEK , ERK , p38 and JNK , respectively . Positive_regulation MAPK9 IL1B 17390080 1716148 We have previously demonstrated that *induced* HBD-2 mRNA expression in A549 cells through activation of nuclear factor-kappaB (NF-kappaB) transcriptional factor as well as p38 [mitogen activated protein kinase (MAPK)] , c-Jun N-terminal kinase (JNK) , or phosphatidylinositol-3-kinase (PI3K) . Positive_regulation MAPK9 IL1B 17390080 1716169 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Positive_regulation MAPK9 IL1B 17390080 1716199 Triptolide inhibited *induced* [MAPK] phosphatase-1 expression at the transcriptional level and resulted in sustained phosphorylation of JNK or p38 MAPK , explaining the little effect of triptolide on IL-1beta induced phosphorylation of these kinases . Positive_regulation MAPK9 IL1B 17438131 1742788 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by TNF-alpha and , but not by ansiomycin or sorbitol . Positive_regulation MAPK9 IL1B 17559635 1753269 also *activated* extracellular signal regulated kinase , p38 [MAPK] , and c-Jun N-terminal kinase . Positive_regulation MAPK9 IL1B 17645739 1793277 Interestingly , Dex attenuated mediated *activation* of p38 [MAPK] and JNK , but not of AKT . Positive_regulation MAPK9 IL1B 17694686 1782121 IL-1beta induced NO levels and thermal hyperalgesia in rats , likely via either inhibiting the mediated p38 [MAPK] *activation* and subsequent iNOS induction , or direct attenuation of the central iNOS activity , which therefore reduces the central sensitization of inflammatory pain . Positive_regulation MAPK9 IL1B 17920534 1804197 SA981 at a concentration of 100 microM partially inhibited *induced* phosphorylation of [p38MAPK] and Akt ( 12.0 % and 36.1 % inhibition of each total amount of phosphoprotein under IL-1beta coexistence condition , respectively ) . Positive_regulation MAPK9 IL1B 17925024 1835161 *stimulated* phosphorylation of c-jun amino-terminal kinase , p38 [MAPK] and extracellular signal regulated kinase-1/2 . Positive_regulation MAPK9 IL1B 18026701 1827828 Moreover , glucosamine suppressed the *induced* phosphorylation of p38 [MAPK] ( p < 0.05 at > 0.1 mM ) and the IL-1beta binding to its receptors ( p < 0.05 at 1 mM ) . Positive_regulation MAPK9 IL1B 18065201 1853670 *stimulated* activation of ERK1/2 and p38alpha [MAPK] mediates the transcriptional up-regulation of IL-6 , IL-8 and GRO-alpha in HeLa cells . Positive_regulation MAPK9 IL1B 18348730 1925322 The *activation* or inhibition of p38 [MAPK] by and/or SB203580 was analyzed by western blotting . Positive_regulation MAPK9 IL1B 18348730 1925335 *activated* the phosphorylation of p38 [MAPK] and this effect was abolished by SB203580 . Positive_regulation MAPK9 IL1B 18427719 1920730 Phosphorylated p38 ( Phos-p38 ) [mitogen activated protein kinase] was *stimulated* in SW-1353 cells by but not by HA alone . Positive_regulation MAPK9 IL1B 18556347 1965945 or leptin individually *induced* threonine/tyrosine phosphorylation of p38 [MAPK] , whereas only leptin induced tyrosine phosphorylation of JAK2 , suggesting that leptin may enhance hBD-2 production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with NF-kappaB , which is activated by IL-1beta . Positive_regulation MAPK9 IL1B 18667841 1948059 Furthermore , induced p38 [mitogen activated protein kinase (MAPK)] *activation* and upregulation of VEGF-C mRNA and protein in LLC cells was also suppressed by artemisinin or by the p38 MAPK inhibitor SB-203580 , suggesting that p38 MAPK could serve as a mediator of proinflammatory cytokine induced VEGF-C expression . Positive_regulation MAPK9 IL1B 19362079 2081466 *induced* the phosphorylation of inhibitor kappa B ( IkappaB ) , p38 [mitogen activated protein (MAP) kinase] , p44/p42 MAP kinase , stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and signal transducer and activator of transcription ( STAT ) 3 . Positive_regulation MAPK9 IL1B 19522843 2136346 In chondrocytes , CS diminishes *induced* increases in p38 [mitogen activated protein kinase] ( p38MAPK ) and signal regulated kinase 1/2 ( Erk1/2 ) phosphorylation , and decreases nuclear factor-kappaB (NF-kappaB) nuclear translocation and as a consequence , reduces the formation of pro-inflammatory cytokines , IL-1beta and TNF-alpha , and pro-inflammatory enzymes , such as phospholipase A2 (PLA2) , cyclooxygenase 2 (COX-2) and nitric oxide synthase-2 (NOS-2) . Positive_regulation MAPK9 IL1B 19765281 2163530 Treatment with PIP-18 blocked *induced* p38 [MAPK] phosphorylation and resulted in attenuation of sPLA2-IIA and MMP mRNA transcription in RA SF cells . Positive_regulation MAPK9 IL1B 20060906 2218528 In the present study , we demonstrate that *caused* activation of p38 [mitogen activated protein kinase] and that the p38 inhibitor SB203580 significantly blocked the effect of IL-1beta on I ( NMDA-OUT ) in hippocampal CA1 neurons . Positive_regulation MAPK9 IL1B 20353947 2266489 In model 1 , a differentiation model , CLA *activation* of [MAPK] and induction of interleukin-8 (IL-8) , IL-6 , , and cyclo-oxygenase-2 (COX-2) were greatest in differentiated compared with undifferentiated cultures . Positive_regulation MAPK9 IL1B 20525168 2284216 We have shown that *induced* miR-146a expression in HASM and that this was regulated at the transcriptional level by NF-kappaB and at the post-transcriptional level by the MEK-1/2 and [JNK-1/2] . Positive_regulation MAPK9 IL1B 21659536 2455201 Distinct roles for Nod2 protein and autocrine in muramyl dipeptide *induced* [mitogen activated protein kinase] activation and cytokine secretion in human macrophages . Positive_regulation MAPK9 IL1B 24692548 2935252 At 1 h , this was responsible for the dexamethasone inhibition of *induced* [MAPK] activation and CXCL1 and CXCL2 mRNA expression , with a similar trend for CSF2 . Positive_regulation MAPK9 IL1B 9475519 486798 Of these , *activated* only [MAPK] . Positive_regulation MAPK9 IL1B 9475519 486811 In cultured rat astrocytes , *caused* activation of [MAPK] without inducing proliferation . Positive_regulation MAPK9 IL1B 9513050 492072 Both JNK1 and [JNK2] were *activated* by . Positive_regulation MAPK9 IL1B 9575890 502756 Our data also indicate that both insulin and IGF-I enhance *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation and SAPK activation . Positive_regulation MAPK9 IL1B 9582321 503943 Previously we reported that *induces* activation of JNK/SAPK and p38 [MAPK] with concomitant up-regulation of cyclooxygenase (Cox)-2 expression and prostaglandin E2 ( PGE2 ) synthesis . Positive_regulation MAPK9 IL1B 9614146 509336 By Western blotting with phosphospecific antibodies and by immunocomplex kinase assay , was shown to *activate* extracellular signal regulated kinase ( ERK ) 1/2 and p38 [mitogen activated protein kinase] ( p38 ) in islets and rat insulinoma cells . Positive_regulation MAPK9 IL1B 9786861 540921 We reported previously that rapidly *activates* the c-Jun NH2-terminal/stress activated protein kinases ( JNK/SAPK ) and p38 [mitogen activated protein kinase (MAPK)] and also induces Cox-2 expression and prostaglandin E2 ( PGE2 ) production . Positive_regulation MAPK9 IL1B 9786861 540967 Overexpression of the kinase-dead form of MKK3 or MKK6 demonstrated that either of these two mutant kinases inhibited *induced* p38 [MAPK] phosphorylation and Cox-2 expression but not JNK/SAPK phosphorylation and activation . Positive_regulation MAPK9 ITGB2 12600815 1099092 IL-3 , IL-5 , and GM-CSF could enhance p38 [MAPK] and NF-kappaB activity and *induce* ICAM-1 , CD11b , and expressions on eosinophils . Positive_regulation MAPK9 ITGB2 19843511 2203208 Furthermore , beta2 integrins modulated the capacity of isolated peritoneal macrophages to take up acetylated LDL and native LDL and to phagocytose apoptotic cells , possibly via *dependent* [mitogen activated protein kinase] signalling . Positive_regulation MAPK9 LBP 20615568 2309976 Despite activating NFkappaB , NOD1 ligand did not upregulate hepatocyte production of the acute phase proteins lipopolysaccharide binding protein , serum amyloid A , or soluble CD14 in cell culture supernatants , or upregulate mRNA expression of , serum amyloid A , C-reactive protein , or serum amyloid P . NOD2 ligand ( MDP ) did not *activate* hepatocytes when given alone , but did synergize with Toll-like receptor ligands , lipopolysaccharide (LPS) , and polyI : C to activate NFkappaB and [MAPK] . Positive_regulation MAPK9 MAP2K6 10050043 592989 In one set of experiments , we *inhibited* the activation of [MAPK] by pretreating cells with PD098059 , a specific inhibitor of ( MAPKK ) , the immediate upstream activator of MAPK . Positive_regulation MAPK9 MAP2K6 10079106 595503 Although MKK3 , MKK4 , and all *activated* p38 [MAPk] in experimental models , only MKK3 was found to activate recombinant p38 MAPk in LPS treated neutrophils . Positive_regulation MAPK9 MAP2K6 10471331 641676 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Positive_regulation MAPK9 MAP2K6 10601295 574429 In addition , *activation* of p38 [MAPK] by constitutively active or MKK3b was not sufficient to induce MMP-13 expression . Positive_regulation MAPK9 MAP2K6 10713051 674444 Conversely , the inhibitors PD98059 and UO126 could *attenuate* EGF induced [mitogen activated protein kinase] activation , they do not affect the EGF induced mobility shift of caveolin-1 . Positive_regulation MAPK9 MAP2K6 10759527 683208 These results demonstrate that a plant can phosphorylate and *activate* [MAPK] , and that Tyr phosphorylation is critical for the catalytic activity of MAPK in plants . Positive_regulation MAPK9 MAP2K6 10816593 714754 The MAPK kinase selectively *stimulates* p38 [MAPK] and confers protection against stress induced apoptosis in cardiac myocytes . Positive_regulation MAPK9 MAP2K6 10891559 711252 MAP kinases (MAPK) in both G-1 and G-5 cells were indistinguishably phosphorylated , yet dependent [MAPK] *activation* was observed only in G-5 cells . Positive_regulation MAPK9 MAP2K6 11005808 752479 A inhibitor , PD98059 , *inhibited* heat shock ERK [MAPK] activation by > 75 % . Positive_regulation MAPK9 MAP2K6 11085935 750751 Similarly , *activation* of JNK by Ad-MKK7D and [p38-MAPK] by resulted in the increased expression of PGHS-2 . Positive_regulation MAPK9 MAP2K6 11237743 790364 The MAPK kinase ( ) inhibitor , PD98059 , *blocked* GSA stimulated [MAPK] activation and resulted in an inhibition of GSA stimulated VSMC proliferation . Positive_regulation MAPK9 MAP2K6 11304531 826854 The *activation* of p38 [MAPK] by Galpha ( q ) and Gbetagamma was blocked by kinase-deficient MKK3 and but not by kinase-deficient MKK4 . Positive_regulation MAPK9 MAP2K6 11787422 891986 Indeed the MAPK kinase ( = ) inhibitor PD98059 *inhibits* the activation of parasite [MAPK] , suggesting that a MEK homologue could be responsible for the dual phosphorylation of MAPK on tyrosine and threonine residues , necessary for their activation . Positive_regulation MAPK9 MAP2K6 11822870 909114 Furthermore , we also investigated the effects of growth factors on telomerase activity during liver regeneration and the influence of [MAPK] pathway *inhibitors* ( inhibitors PD98059 and U0126 ; p38 MAPK inhibitor SB203580 ) on the telomerase activity of regenerating hepatocytes in vitro . Positive_regulation MAPK9 MAP2K6 12009309 940872 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Positive_regulation MAPK9 MAP2K6 12203369 983278 Furthermore , PKC inhibitors or an inhibitor completely *suppressed* both TPA induced activation of [MAPK] and promotion of anchorage independent growth , but a cPKC-selective inhibitor partially suppressed TPA induced promotion of the growth . Positive_regulation MAPK9 MAP2K6 12356282 993912 IL-1beta induced p44/42 [mitogen activated protein kinase (MAPK)] activation was *inhibited* by the MAPK/extracellular signal regulated protein kinase ( ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation MAPK9 MAP2K6 12377770 1020002 These results suggest that MKK3 , rather than , *mediates* alphav integrin induced p38 [MAPK] activation . Positive_regulation MAPK9 MAP2K6 12450322 1018696 ANG II significantly increased aldosterone release , and this effect was inhibited by the LO inhibitor baicalein , as well as a specific p38 [MAPK] *inhibitor* , SB202190 , but not by PD098059 , a specific inhibitor of the ERK activator . Positive_regulation MAPK9 MAP2K6 12637559 1085556 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Positive_regulation MAPK9 MAP2K6 12659851 1073568 MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a ( MAP2K ) , which in turn *activates* a [mitogen activated protein kinase (MAPK)] . Positive_regulation MAPK9 MAP2K6 12782417 1096165 Finally , we demonstrate for the first time that MKK7 serves as an upstream activator of p38 MAPK and that MKK3 and *activates* 54 kDa [JNK2] in aged liver . Positive_regulation MAPK9 MAP2K6 12845643 1108648 Finally , both ODQ and UO126 blocked the capacity of L-arginine to restore ERK ( 1/2 ) phosphorylation in L-NAME treated cells , demonstrating that GC and are both *required* for endogenous NO-mediated [MAPK] activation . Positive_regulation MAPK9 MAP2K6 15104236 1240371 However , none of the follows affected magnolol induced AA-release : 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) , a p38 [mitogen activated protein kinase (MAPK)] *inhibitor* , 1,4-diamino-2,3-dicyano-1,4-bis ( 2-aminophenylthio ) butadiene ( U0126 ) , a MAPK kinase ( ) inhibitor , or 2- [ 1- ( 3-dimethylaminopropyl ) -1H-indol-3-yl ] -3- ( 1H-indol-3-yl ) -maleimide ( GF109203X ) , a protein kinase C ( PKC ) inhibitor . Positive_regulation MAPK9 MAP2K6 15172888 1288448 Importantly , the presence of inhibitors only at the time of the transport assay markedly *impaired* both insulin stimulated glucose uptake and [MAPK] signaling . Positive_regulation MAPK9 MAP2K6 15172888 1288539 Conversely , removal of inhibitors before the transport assay *restored* glucose uptake and [MAPK] signaling . Positive_regulation MAPK9 MAP2K6 15304546 1322566 Furthermore , *activation* of [ERK/MAPK] by the coexpression of constitutively active predominantly augmented the expression of wt-CFTR , but not of DeltaR-CFTR , induced by butyrate . Positive_regulation MAPK9 MAP2K6 15365248 1294624 Treatment of keratinocytes with PD98059 , inhibitor , and SB20358 , p38 [MAPK] *inhibitor* , before Ca2+ shift induced morphological changes and reduced expressions of differentiation markers , but treatment with SP60012 , JNK1/2 inhibitor , did not change at all . Positive_regulation MAPK9 MAP2K6 15570612 1355620 Although the inhibitors *suppressed* [MAPK] phosphorylation in both OA- and AICAR treated oocytes , meiotic resumption was not causally linked to MAPK phosphorylation in either group . Positive_regulation MAPK9 MAP2K6 15867183 1404250 In cultured cardiac myocytes , specific *activation* of stress activated [mitogen activated protein kinase] , p38 , by upstream activator led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation MAPK9 MAP2K6 15879307 1411365 Conversely , constitutively active *induced* p38 [MAPK] activation that recapitulated the effects of polyphenols by inducing ERalpha phosphorylation and downstream activation of Akt , and eNOS . Positive_regulation MAPK9 MAP2K6 16157033 1455816 SB203580 , a [P38MAPK] *inhibitor* , and U0126 , a inhibitor , both completely blocked ADM mediated responses in MsC . Positive_regulation MAPK9 MAP2K6 17416211 1777941 While MCT-1 gene knockdown or pathway inhibition dramatically *reduced* [MAPK] phosphorylation , the genotoxin induced p53 and p21 production were noticeably elevated . Positive_regulation MAPK9 MAP2K6 18401006 1925897 CyaA enhanced LPS induced phosphorylation of p38 [MAPK] and ERK in DC , and inhibitors of p38 MAPK , , or NF-kappaB *suppressed* IL-10 production in response to LPS and CyaA . Positive_regulation MAPK9 MAP2K6 18754769 1968492 ( MKK) 3 and 6 are the main p38 [mitogen activated protein kinase] *activators* in mammals . Positive_regulation MAPK9 MAP2K6 18771907 1962737 The PGD2 stimulated IL-6 synthesis was reduced by PD98059 , a inhibitor , and SB203580 , an *inhibitor* of p38 [mitogen activated protein (MAP) kinase] , but not SP600125 , an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) . Positive_regulation MAPK9 MAP2K6 21892182 2491670 Further , we show that *activation* of p38 [MAPK] by expression of constitutively active ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation MAPK9 MAP2K6 22164285 2517918 Here , we found that sensitivity to cisplatin , in a system of 7 non-small cell lung carcinoma derived cell lines , correlated with high levels of and marked *activation* of p38 [MAPK] . Positive_regulation MAPK9 MAP2K6 22785235 2691950 TRH induced CRE promoter was inhibited by [mitogen activated protein kinase/ERK] kinase ( MEK ) inhibitor and was *increased* by overexpression of . Positive_regulation MAPK9 MAP2K6 7644477 318721 Inhibition of by PD 098059 *prevented* activation of [MAPK] and subsequent phosphorylation of MAPK substrates both in vitro and in intact cells . Positive_regulation MAPK9 MAP2K6 7822248 285654 ( MKK ) phosphorylates and *activates* [mitogen activated protein kinase (MAPK)] in response to stimulation of various eukaryotic signaling pathways . Positive_regulation MAPK9 MAP2K6 7889302 289498 2. Both nucleotides stimulate phosphorylation and *activation* of [mitogen activated protein kinase] and a biphasic phosphorylation of the up-stream . Positive_regulation MAPK9 MAP2K6 8180183 256298 This stimulation of the activator was temporally *followed* by increased activities of MEK and [MAPK] . Positive_regulation MAPK9 MAP2K6 8226933 235469 *Activation* of extracellular signal regulated kinase ( ERK ) or [mitogen activated protein kinase] by ( mitogen activated protein kinase or extracellular signal regulated kinase kinase ) is an essential event in the mitogenic growth factor signal transduction . Positive_regulation MAPK9 MAP2K6 8394352 228299 We show that a similar activity phosphorylates and *activates* [MAPK] in both growth factor stimulated ( epidermal growth factor and thrombin ) and oncogene ( gip2 , v-src , and v-raf ) -transfected cells . Positive_regulation MAPK9 MAP2K6 8550616 346734 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Positive_regulation MAPK9 MAP2K6 8663100 368216 The [MAPK] and NHE activities induced by PMA were *inhibited* by staurosporine , a potent inhibitor for protein kinase C ( PKC ) , and by MAPK kinase ( ) inhibitor , PD98059 , but were not affected by the tyrosine kinase inhibitor genistein . Positive_regulation MAPK9 MAP2K6 8663100 368319 In contrast , both AVP induced [MAPK] and NHE activities were *inhibited* by genistein and inhibitor but were not affected by staurosporine . Positive_regulation MAPK9 MAP2K6 8816498 384353 *activates* [mitogen activated protein kinase (MAPK)] , which phosphorylates other kinases as well as transcription factors . Positive_regulation MAPK9 MAP2K6 9135064 427670 In addition to *dependent* [MAPK] activation , we provide evidence for MEK independent regulation of the MAPKs . Positive_regulation MAPK9 MAP2K6 9166761 432518 The first step in [MAPK] *activation* by must be the formation of a MEK x MAPK enzyme-substrate complex , followed by phosphorylation producing monophosphorylated MAPK ( pMAPK ) . Positive_regulation MAPK9 MAP2K6 9626658 511964 These results indicate that *mediates* the IGF-I/insulin induced p42/ p44 [MAPK] activation . Positive_regulation MAPK9 MAP2K6 9864179 582787 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of ERK , but not p38 [MAPK] , induced by G-CSF , GM-CSF , or TNF . Positive_regulation MAPK9 MMP28 11920420 926210 Complete inhibition of expression and joint destruction will likely *require* combined JNK-1 and [JNK-2] inhibition . Positive_regulation MAPK9 MMP7 11920420 926225 Complete inhibition of expression and joint destruction will likely *require* combined JNK-1 and [JNK-2] inhibition . Positive_regulation MAPK9 MMP7 16848631 1588335 and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 [mitogen activated protein kinase] activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MAPK9 MMP7 21999204 2547392 Mesothelin enhances invasion of ovarian cancer by *inducing* through [MAPK/ERK] and JNK pathways . Positive_regulation MAPK9 MUC16 11481474 843969 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a [mitogen activated protein kinase] ( Erk 1/2 ) , and *activation* of transcription . Positive_regulation MAPK9 PECAM1 18029285 1866929 In contrast , expression of Delta15 in PECAM-1-/- bEND cells *had* minimal effects on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Positive_regulation MAPK9 PGC 22105890 2599549 Our studies also revealed that overexpression of in cardiomyocytes *inhibited* basal and T3-induced p38 [MAPK] phosphorylation . Positive_regulation MAPK9 PIGR 20450283 2257155 Induction of expression in HT-29 cells *required* NF-kappaB signaling but not [MAPK] signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation MAPK9 PLAT 19436314 2107046 cerebrospinal fluid and brain parenchymal ERK [MAPK] was elevated by H/I and this upregulation was *potentiated* by , but blunted by RBC-tPA . Positive_regulation MAPK9 PLAT 21037505 2499502 Red blood blocked c-Jun-N-terminal kinase but *potentiated* p38 [mitogen activated protein kinase] upregulation after photothrombotic injury . Positive_regulation MAPK9 PLAU 10766865 684612 surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha [mitogen activated protein kinase] activity . Positive_regulation MAPK9 PLAU 15031204 1257176 In HeLa cells the dominant negative form of JNK interferes with the p42/p44 [MAPK] *activation* of the . Positive_regulation MAPK9 PLAU 15874933 1405705 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 [MAPK] , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Positive_regulation MAPK9 PLAU 15874933 1405738 Although *induced* phosphorylation of both ERK1/2 and p38 [MAPK] was blocked by Galphai inhibition , inhibition of PI3K and Ras decreased the uPA induced phosphorylation of ERK1/2 but not p38 MAPK . Positive_regulation MAPK9 PLAU 18656457 1960571 Exogenous administered at 4 h post H/I further *stimulated* ERK [MAPK] phosphorylation , which was blocked by RAP . Positive_regulation MAPK9 PLAU 9660790 517506 The receptor *mediates* tyrosine phosphorylation of focal adhesion proteins and activation of [mitogen activated protein kinase] in cultured endothelial cells . Positive_regulation MAPK9 PLAU 9660790 517519 The induced *activation* of [MAPK] was completely inhibited by genistein , but not by 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo [ 3 , 4-d ] pyrimidine , a specific inhibitor of Src family kinases . Positive_regulation MAPK9 PODXL 17616675 1769280 expression also *led* to an increase in [mitogen activated protein kinase (MAPK)] and phosphatidylinositol 3-kinase (PI3K) activity . Positive_regulation MAPK9 PODXL 17616675 1769327 These findings suggest that leads to increased in vitro migration and invasion , increased MMP expression , and *increased* activation of [MAPK] and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MAPK9 PTGER2 19233324 2072066 Further , PGE ( 2 ) , EP2A and EP4A did not increase BMP2/4 mRNA levels in RC cells , and *induced* phosphorylation of p38 [MAPK] was not eliminated by Noggin . Positive_regulation MAPK9 SLC38A3 15331357 1288052 In contrast , *stimulated* [MAPK] activation was blocked by > 80 % by dominant negative Ras but not by dominant negative Rho and Cdc42 . Positive_regulation MAPK9 SNCAIP 12639553 1068710 In addition , [MAPK] was *activated* by through Edg-1 , Sph-1-P receptor . Positive_regulation MAPK9 SPHK1 18602364 1941518 As a result , inhibition of by SKI *blocked* phosphorylation of p38 [MAPK] , showing that SPHK activation by IL-18 is an upstream signal of p38 MAPK activation . Positive_regulation MAPK9 STK39 17237610 1690376 The phosphorylation of cytoplasmic p38 [MAPK] in Akata cells was *reduced* by the inhibitor , 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperazine ( H7 ) . Positive_regulation MAPK9 TLR7 16424221 1515635 MKP-1-deficient macrophages also show enhanced constitutive and induced *activation* of p38 [MAPK] . Positive_regulation MAPK9 TLR7 23979601 2850715 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Positive_regulation MAPK9 TLR7 24879442 2941066 GIT2 terminates *induced* NF-?B and [MAPK] signaling by recruiting the deubiquitinating enzyme Cylindromatosis to inhibit the ubiquitination of TRAF6 . Positive_regulation MAPK9 TNF 10504489 648989 Pretreatment with SB203580 ( 10 microM ) had no effect on basal or TNF-alpha stimulated phosphorylation of p38 MAPK but completely abolished *stimulated* p38 [MAPK] activity . Positive_regulation MAPK9 TNF 10521481 653119 The study presented here shows that autoregulation of gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 [mitogen activated protein (MAP) kinase] activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation MAPK9 TNF 10570180 568167 Furthermore , LPS , UV irradiation , and *caused* activation of p38 [MAPK] whereas IFN-gamma did not . Positive_regulation MAPK9 TNF 10601128 574224 alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 [MAPK] , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation MAPK9 TNF 10640438 577517 IL-1 beta and also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation MAPK9 TNF 10669634 665814 In this study , we show that *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation MAPK9 TNF 10753884 682349 Moreover , *stimulated* both the NF-kappaB and [mitogen activated protein (MAP) kinase] ( extracellular signal regulated kinase , c-Jun NH ( 2 ) -terminal kinase , and p38 MAP kinase ) signaling pathways in astrocytes . Positive_regulation MAPK9 TNF 10783388 707856 dependent p38 [MAPK] *activation* was detected in both Mo7e and Hut-78 cells and was blocked by the p38 MAPK inhibitor , SB203580 . Positive_regulation MAPK9 TNF 10783388 707909 SB203580 did not affect TNF-alpha signaled nuclear translocation and DNA binding activity of NF-kappaB , and inhibition of NF-kappaB function did not affect induced p38 [MAPK] *activation* , indicating that these events are not dependent on each other . Positive_regulation MAPK9 TNF 10864897 705739 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Positive_regulation MAPK9 TNF 10864897 705791 Pretreatment of TSMCs with pertussis toxin did not change DNA synthesis and phosphorylation of [MAPK] *induced* by and IL-1beta . Positive_regulation MAPK9 TNF 11095634 755306 rapidly *activated* [MAPK] and increased the extent of attachment , spreading and migration on fibronectin and collagen type I ( P < 0.01 ) but not on collagen type IV . Positive_regulation MAPK9 TNF 11108246 756735 *activates* extracellular regulated kinase-1/2 ( ERK1/2 ) and [p38MAPK] . Positive_regulation MAPK9 TNF 11108836 757046 In RAW264 cells which differentiate into osteoclast-like multinucleated cells by TNF treatment alone , activation of p38 [mitogen activated protein (MAP) kinase] *induced* by murine was comparable to and independent of the receptor activator of necrosis factor-kappaB ligand . Positive_regulation MAPK9 TNF 11156586 780622 1. We have previously shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce interleukin-8 (IL-8) by human pulmonary vascular endothelial cells . Positive_regulation MAPK9 TNF 11167962 783073 It has previously been shown that *activates* p38 [mitogen activated protein (MAP) kinase] to produce cytokine , including RANTES , that N-acetylcysteine (NAC) attenuates cytokine production by human bronchial epithelial cells ( BECs ) , and that sensitivity to TNFalpha is inversely correlated with cellular redox state . Positive_regulation MAPK9 TNF 11266661 797176 However , *caused* no activation of p42/p44 [MAPK] or cytosolic phospholipase A(2) activity . Positive_regulation MAPK9 TNF 11277995 798118 *activates* extracellular regulated kinases ( ERKs ) and p38 [mitogen activated protein kinase] ( p38MAPK ) , and inhibits the expression of uncoupling protein-1 (UCP-1) and adipocyte-specific genes in rat fetal brown adipocytes . Positive_regulation MAPK9 TNF 11319753 806846 SB 203580 , a selective inhibitor of p38 MAPK , inhibited IL-1 and *induced* p38 [MAPK] activity and IL-6 production ( IC ( 50 ) s 0.3 -- 0.5 microM ) in osteoblasts and chondrocytes . Positive_regulation MAPK9 TNF 11319753 806883 In addition , IL-1 and also *activated* p38 [MAPK] in fetal rat long bones and p38 MAPK inhibitors inhibited IL-1- and TNF stimulated bone resorption in vitro in a dose dependent manner ( IC ( 50 ) s 0.3 -- 1 microM ) . Positive_regulation MAPK9 TNF 11435466 832536 However , the cytotoxic responses to daunorubicin and exogenous ceramide remain unaltered , as do the *induced* p42/p44 [MAPK] activation and CD54 expression . Positive_regulation MAPK9 TNF 11438547 843401 *activated* p38 [MAPK] and p44/p42 MAPK in wild-type but not in p60 ( -/- ) , p80 ( -/- ) , or p60 ( -/- ) p80 ( -/- ) macrophages . Positive_regulation MAPK9 TNF 11494147 846180 In this study we demonstrate that *triggers* only modest proliferation , as well as p44/p42 [mitogen activated protein kinase (MAPK)] and NF-kappaB activation , in MM.1S multiple myeloma ( MM ) cells . Positive_regulation MAPK9 TNF 11495721 846406 Furthermore , overexpression of dominant negative mutants , H-Ras-15A and Raf-N4 , significantly suppressed p42/p44 [mitogen activated protein kinase (MAPK)] activation *induced* by and PDGF-BB and attenuated the effect of TNF-alpha on BK-induced IP response , indicating that Ras and Raf may be required for activation of these kinases . Positive_regulation MAPK9 TNF 11509550 848381 Although IL-1 beta and each increased nuclear factor-kappa B activation and induced extracellular regulated kinase and p38 phosphorylation , combined administration of the cytokines did not *enhance* either nuclear factor-kappa B or [mitogen activated protein kinase] activation . Positive_regulation MAPK9 TNF 11592111 869675 Lipopolysaccharide (LPS) treatment of a microglial cell line ( N9 ) *induced* a time dependent activation of both p38 [mitogen activated protein kinase] ( p38 MAPK ) and nuclear factor-kappaB (NFkappaB) , with consequent increases in interleukin-1alpha (IL-1alpha) , , and nitric oxide ( NO ) production . Positive_regulation MAPK9 TNF 11694522 896421 *activated* the three mammalian [MAPK] , p44/42 , JNK , and p38 , in a distinct time- and concentration dependent manner . Positive_regulation MAPK9 TNF 11694522 896447 In conclusion , although *activates* all three known [MAPK] in human preadipocytes , only p44/42 and JNK appear to be involved in the regulation of lipolysis . Positive_regulation MAPK9 TNF 11750919 898179 Biochemical and immunocytochemical analysis showed that *activated* p38 mitogen activated protein kinase ( p38MAPK ) and c-Jun N-terminal kinase (JNK) but not p42/p44 [MAPK] . Positive_regulation MAPK9 TNF 11820362 908746 *activated* p38 [MAPK] and stimulated IL-6 secretion by MG-63 cells , and pre-incubation of cells with the p38 MAPK inhibitor abrogated TNF-alpha dependent IL-6 secretion . Positive_regulation MAPK9 TNF 11820362 908775 Transfection of IL-6 full-length and 5-deletion gene promoter reporter constructs indicated that p38 [MAPK] *activation* by enhanced IL-6 gene expression , and that the p38 MAPK-responsive region resided in the proximal 260-bp segment . Positive_regulation MAPK9 TNF 11820362 908811 In conclusion , although p38 [MAPK] *activation* by stimulates IL-6 secretion by MG-63 cells , it has opposing effects on c/EBPbeta and NFkappaB activity . Positive_regulation MAPK9 TNF 11930247 927426 The p44/42 [MAPK] activity was significantly *enhanced* by and the TNF-alpha effect was opposed by rhIL-10 . Positive_regulation MAPK9 TNF 11930247 927439 It is suggested that rhIL-10 can inhibit *induced* VSMC proliferation and phosphorylation of p44/42 [MAPK] . Positive_regulation MAPK9 TNF 12095140 960572 significantly increased permeability and *induced* p38 and ERK [MAPK] activation compared with controls ( P < 0.05 ) . Positive_regulation MAPK9 TNF 12114204 964002 *increased* the phosphorylation of p38 [MAPK] within 15 min. Anisomycin , an activator of p38 MAPK , increased p38 MAPK phosphorylation and decreased SP-A mRNA levels in a dose dependent manner . Positive_regulation MAPK9 TNF 12130576 966594 Phosphorylation of p38 [MAPK] was *induced* by RANKL , IL-1 , , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation MAPK9 TNF 12131776 966872 IL-1 beta and *activated* extracellular signal regulated kinase 1/2 , c-Jun N-terminal kinase/stress activated protein kinase , and p38 [mitogen activated protein kinase] . Positive_regulation MAPK9 TNF 12297009 991045 In this study , we examined the anti-apoptotic role of p38 [MAPK] that is *activated* by in neuronal PC12 cells . Positive_regulation MAPK9 TNF 12297009 991058 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Positive_regulation MAPK9 TNF 12393915 1025449 This model probiotic also inhibits *activation* of the pro-apoptotic [p38/mitogen activated protein kinase] by , interleukin-1alpha , or gamma-interferon . Positive_regulation MAPK9 TNF 12511413 1079058 The treatment of RAW264 cells with TSA and NaB inhibited induced nuclear translocation of NF-kappa B and sRANKL induced *activation* of p38 [mitogen activated protein kinase (MAPK)] signals . Positive_regulation MAPK9 TNF 12631113 1067623 Additional experiments examining the role of cAMP on MC fractalkine expression showed that the incubation of MCs with TNF-alpha and either db-cAMP or forskolin attenuated TNF-alpha stimulated fractalkine mRNA and protein expression , preceded by attenuation of *activated* phosphorylation of p42/44 [MAPK] , and c-Jun , but not phosphorylation of PKCzeta/iota or nuclear translocation of NF-kappaB . Positive_regulation MAPK9 TNF 12637577 1099329 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and *requires* p38 [MAPK] activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation MAPK9 TNF 12665666 1030378 This study was undertaken to examine the relationship between induced cardiomyocyte apoptosis and *activation* of p38 [mitogen activated protein kinase (MAPK)] through oxidative stress . Positive_regulation MAPK9 TNF 12665666 1030391 Corresponding to the apoptotic effect , at 10 ng/mL *caused* rapid phosphorylation of p38 [MAPK] in wild-type cardiomyocytes . Positive_regulation MAPK9 TNF 12694807 1080917 *induced* the phosphorylation of p44/p42 [mitogen activated protein (MAP) kinase] and p38 MAP kinase . Positive_regulation MAPK9 TNF 12731668 1086853 On the other hand , GM-CSF- or *induced* phosphorylation of ERK and p38 [MAPK] was unaffected by these inhibitors at the concentrations effective for the inhibition of O2- release and adherence . Positive_regulation MAPK9 TNF 12829618 1113812 However , *induced* [p38-MAPK] phosphorylation was markedly diminished in mkk3-/- vs mkk3+/+ hearts ( percent basal , 127+/-23 versus 540+/-267 , respectively , P=0.04 ) , suggesting an MKK independent activation mechanism by ischemia . Positive_regulation MAPK9 TNF 12844496 1149736 Rho inhibition decreases induced endothelial [MAPK] *activation* and monolayer permeability . Positive_regulation MAPK9 TNF 12844496 1149749 Because GTP binding proteins have been implicated in MAPK activation , we now hypothesize that the GTP binding protein Rho is a mediator of *induced* [MAPK] activation and increased endothelial permeability . Positive_regulation MAPK9 TNF 12844496 1149763 C3 transferase attenuated induced [MAPK] *activation* and blocked TNF induced endothelial permeability . Positive_regulation MAPK9 TNF 12867430 1142034 Subsequently , mediated p38 [MAPK] *activation* induced sialidase activity and CD44-HA binding . Positive_regulation MAPK9 TNF 12867430 1142113 Taken together , our results suggest that *induced* p38 [MAPK] activation may regulate the induction of functionally active HA-binding form of CD44 by activating sialidase in LPS stimulated human monocytic cells . Positive_regulation MAPK9 TNF 12881424 1116138 Importantly , does not induce ROS accumulation or prolonged MAPK activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently *induces* prolonged [MAPK] activation and necrotic cell death Positive_regulation MAPK9 TNF 12893778 1121036 We show that MKK3 and MKK6are essential for *stimulated* p38 [MAPK] activation . Positive_regulation MAPK9 TNF 12960255 1158294 To investigate a potential interplay between induced *activation* of p38 [MAPK] and NF-kappaB , the p38 MAPK inhibitor SB203580 and a dominant negative p38 MAPK mutant were used . Positive_regulation MAPK9 TNF 14516792 1147210 [MAPK] pathway *activation* via was confirmed by marked AP-1 activation detected in EMSA . Positive_regulation MAPK9 TNF 14561851 1165112 In cultured human umbilical vein endothelial cells ( HUVECs ) , and lipopolysaccharide *increased* phosphorylation of p38 [MAPK] ( P-p38 MAPK ) and increased ICAM-1 expression . Positive_regulation MAPK9 TNF 14592823 1209471 Analyzing the individual contribution of PF-4 and its costimuli in the control of these functions at the signaling level , we demonstrate that *induced* activation of p38 [mitogen activated protein (MAP) kinase] ( but not extracellular regulated kinase [ Erk ] kinases ) acts as general and essential costimulatory signal in PF-4 dependent neutrophil exocytosis . Positive_regulation MAPK9 TNF 14632659 1170657 *activated* p38 [MAPK] in DCs only at an early time-point ( 15 min ) . Positive_regulation MAPK9 TNF 14654378 1176835 These findings suggest that the pre-ischemic *activation* of [p38-MAPK] by does not contribute to cardioprotection afforded by this agent . Positive_regulation MAPK9 TNF 15002040 1265094 Consistent with the abrogation of osteoclastogenic effect of DcR3 by TNFR-Fc , DcR3 treatment can *induce* osteoclastogenic cytokine release through ERK and p38 [MAPK] signaling pathways . Positive_regulation MAPK9 TNF 15139014 1246964 The increase in release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not [mitogen activated protein kinase (MAPK)] , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation MAPK9 TNF 15191888 1295246 Treatment of endothelial cells with SphK1 siRNA suppressed *induced* increase in MCP-1 mRNA levels , MCP-1 protein secretion , and activation of p38 [MAPK] . Positive_regulation MAPK9 TNF 15212763 1262330 Interestingly , Ad5NIK , but not , *induces* RelA S536 and p38 [mitogen activated protein kinase (MAPK)] phosphorylation in IKKgamma ( -/- ) cells . Positive_regulation MAPK9 TNF 15233873 1269397 A. semen also inhibited the expression of and the *activation* of [mitogen activated protein kinase] , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation MAPK9 TNF 15240695 1270289 TNF activates Syk protein tyrosine kinase leading to *induced* [MAPK] activation , NF-kappaB activation , and apoptosis . Positive_regulation MAPK9 TNF 15240695 1270309 TNF induced Syk activation was abolished by piceatannol ( Syk-selective inhibitor ) , which led to the suppression of *induced* activation of c- JNK , p38 [MAPK] , and p44/p42 MAPK . Positive_regulation MAPK9 TNF 15240695 1270325 Jurkat cells that did not express Syk ( JCaM1 , JCaM1/lck ) showed lack of *induced* Syk , JNK , p38 [MAPK] , and p44/p42 MAPK activation , as well as TNF induced IkappaBalpha phosphorylation , IkappaBalpha degradation , and NF-kappaB activation . Positive_regulation MAPK9 TNF 15240695 1270356 Overall , our results demonstrate that Syk activation plays an essential role in *induced* activation of JNK , p38 [MAPK] , p44/p42 MAPK , NF-kappaB , and apoptosis . Positive_regulation MAPK9 TNF 15240725 1270464 p38 [MAPK] was *activated* by and oxidants in nonadherent conditions i.e. , with 10 mM EDTA . Positive_regulation MAPK9 TNF 15240725 1270478 Finally , p38 [MAPK] *activation* by was blocked by diphenylene iodonium , an inhibitor of flavoprotein oxidoreductase , and by the free radical scavenger N-acetylcystein . Positive_regulation MAPK9 TNF 15265936 1275740 Besides NF-kappa B , celecoxib also suppressed *induced* JNK , p38 [MAPK] , and ERK activation . Positive_regulation MAPK9 TNF 15290420 1278557 Halothane or isoflurane augmented the LPS- and *induced* activation of p38 [MAPK] . Positive_regulation MAPK9 TNF 15304089 1284486 DNCB , NiSO ( 4 ) and *activated* p38 [mitogen activated protein kinases (MAPK)] and c-jun N-terminal kinase ( JNK ) . Positive_regulation MAPK9 TNF 15322069 1333428 We have also investigated the phosphorylation of p42/44 [MAPK] and *upregulation* of RhoA protein by . Positive_regulation MAPK9 TNF 15452110 1341999 In contrast , *induced* p42/p44 [MAPK] activation and CD54 expression remained unaltered . Positive_regulation MAPK9 TNF 15589482 1356219 In addition , luteolin inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , IkappaB degradation , and NF-kappaB activation . Positive_regulation MAPK9 TNF 15659876 1350320 The anabolic effect of was *mediated* at least in part by [mitogen activated protein kinase (MAPK)] , especially by an extracellular regulated kinases (ERK) . Positive_regulation MAPK9 TNF 15696169 1372174 Using TCPTP-deficient fibroblasts , we show here that TCPTP regulates *induced* [MAPK] but not NF-kappaB signaling . Positive_regulation MAPK9 TNF 15696169 1372208 These results link TCPTP and Src tyrosine kinases to the selective regulation of *induced* [MAPK] signaling and identify a previously unknown mechanism for modulating inflammatory responses mediated by TNF . Positive_regulation MAPK9 TNF 15703956 1497475 *Activation* of p38 [mitogen activated protein (MAP) kinase] and phosphatidylinositol 3-kinase (PI3K) by was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation MAPK9 TNF 15792609 1386801 By stimulation of in AM-1 cells , the phosphorylation of Akt ( Ser473 ) and p44/42 [mitogen activated protein kinase (MAPK)] ( Thr202/Tyr204 ) was markedly *increased* in TNFalpha concentration and time dependent manner . Positive_regulation MAPK9 TNF 15792609 1386814 Pretreatment with U0126 , mitogen activated extracellular regulated kinase ( MEK) 1/2 inhibitor , prior to TNFalpha stimulation , specifically inhibited *induced* phosphorylation of p44/42 [MAPK] ( Thr202/Tyr204 ) in AM-1 cells . Positive_regulation MAPK9 TNF 15792609 1386830 Meanwhile , pretreatment with LY294002 , phosphatidylinositol-3-OH kinase (PI3K) inhibitor , could inhibit both *induced* phosphorylation of Akt ( Ser473 ) and p44/42 [MAPK] ( Thr202/Tyr204 ) . Positive_regulation MAPK9 TNF 15823554 1393919 Furthermore , potently *activated* p38 [MAPK] , JNK , and NF-kappaB . Positive_regulation MAPK9 TNF 15837794 1432556 Expression of this protein inhibited *induced* activation of NFkappaB , JNK , and p38 [MAPK] and sensitized the cells to TNF induced apoptosis . Positive_regulation MAPK9 TNF 15845648 1425554 *induces* a more than tenfold increase in p38 [mitogen activated protein kinase (MAPK)] but not extracellular signal regulated kinase phosphorylation . Positive_regulation MAPK9 TNF 15870903 1405554 In addition , GA inhibited *induced* phosphorylation of p38 [MAPK] and extracellular regulated kinases (ERK) , I kappa B alpha degradation , and NF-kappa B activation . Positive_regulation MAPK9 TNF 16009485 1441417 Moreover , p44/42 [mitogen activated protein kinase] appears to partly *mediate* the negative effect of insulin but not on ATGL . Positive_regulation MAPK9 TNF 16023081 1441595 Ellagic acid inhibited IL-1beta- and induced *activation* of activator protein-1 and mitogen activated protein kinases ( extracellular signal regulated kinase , c-Jun N-terminal kinase and p38 [mitogen activated protein kinase] ) , but not of nuclear factor-kappaB . Positive_regulation MAPK9 TNF 16025396 1435618 *activated* the phosphorylation of p44/42 [MAPK] , p38 MAPK , SAPK/JNK and Akt in mesangial cells . Positive_regulation MAPK9 TNF 16025396 1435634 PGE1 inhibited the *induced* phosphorylation of SAPK/JNK and Akt , but not p44/42 MAPK and p38 [MAPK] . Positive_regulation MAPK9 TNF 16080915 1442774 Comparative gene array analysis of *induced* [MAPK] and NF-kappaB signaling pathways between retinal ganglion cells and glial cells . Positive_regulation MAPK9 TNF 16140562 1499260 These results suggested that TNFalpha induced both cell survival and apoptosis pathways in ameloblastoma and potential of TNFalpha in inducing apoptosis can be improved by inhibiting *induced* Akt and p44/42 [mitogen activated protein kinase (MAPK)] cell survival pathways . Positive_regulation MAPK9 TNF 16275991 1480314 Angiotensin II , , or epidermal growth factor *induced* [MAPK] phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation MAPK9 TNF 16291729 1526077 *Activation* of [MAPK] and Akt by anti-HER2/neu inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation MAPK9 TNF 16314440 1487006 treatment *induced* p38 [mitogen activated protein kinase (MAPK)] phosphorylation in NPCs , and SB202190 , an inhibitor of p38 MAPK , blocked TNF-alpha induced chemokine production . Positive_regulation MAPK9 TNF 16325162 1511671 Furthermore , APE1/ref-1 overexpression inhibited the *induced* increase in intracellular superoxide and p38 [MAPK] phosphorylation . Positive_regulation MAPK9 TNF 16452991 1611750 Western blots showed that IL-1beta and *activated* p38 [MAPK] , in an SB203580-sensitive manner . Positive_regulation MAPK9 TNF 16517732 1530950 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of , but not IL-6 , *requires* the activity of p38 [MAPK] . Positive_regulation MAPK9 TNF 16573652 1556143 HA-mediated production *required* p38 [MAPK] , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation MAPK9 TNF 16682409 1584064 Further , the deletion of NQO1 abolished *induced* c-Jun N-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] activation . Positive_regulation MAPK9 TNF 16781693 1585622 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and and the *activation* of [MAPK] 's are potentially positive signals for IL-10 production . Positive_regulation MAPK9 TNF 16798728 1638541 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Positive_regulation MAPK9 TNF 16875982 1593569 *activates* [p38-MAPK] , a stress-responsive kinase implicated in contractile depression and cardiac injury . Positive_regulation MAPK9 TNF 16875982 1593583 Under conditions of constant coronary flow , the [p38-MAPK] activation and contractile depression *induced* by , though attenuated , remained sensitive to the absence of MKK3 or the presence of SB203580 . Positive_regulation MAPK9 TNF 16875982 1593597 *activates* [p38-MAPK] in the intact heart and in isolated cardiac myocytes through MKK3 . Positive_regulation MAPK9 TNF 16982923 1617369 Compared with wild-type cells , MIF-deficient cells were hyporesponsive to IL-1- and *induced* [MAPK] activity , AP-1 activity , and cellular proliferation , while NF-kappaB function was preserved . Positive_regulation MAPK9 TNF 17070777 1649846 Inhibition of Syk down-regulated *induced* p38 and p44/42 [MAPK] phosphorylation and nuclear translocation of p65 NF-kappaB . Positive_regulation MAPK9 TNF 17099067 1676207 Importantly , Dex is able to increase the expression of MKP-1 , which causes an inactivation of *induced* p38 [MAPK] and mediates inhibition of E-selectin expression . Positive_regulation MAPK9 TNF 17126899 1677680 Stimulation of ECs with *induced* rapid increases in the phosphorylation of their mitogen activated protein kinases ( MAPKs ) [ extracellular signal regulated kinase ( ERK ) , c-Jun-NH2-terminal kinase (JNK) , and p38 [MAPK] ] ; Positive_regulation MAPK9 TNF 17126905 1686561 Differential regulation of and GM-CSF *induced* activation of P38 [MAPK] in neutrophils and eosinophils . Positive_regulation MAPK9 TNF 17138860 1653553 The role of delta-PKC in mediated *activation* of [MAPK] is not known . Positive_regulation MAPK9 TNF 17138860 1653579 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 MAPK are involved in TNF antiapoptotic signaling and whether delta-PKC is a key regulator of [MAPK] *activation* by . Positive_regulation MAPK9 TNF 17138860 1653605 In human neutrophils , *activated* both p38 [MAPK] and ERK1/2 principally via TNFR-1 . Positive_regulation MAPK9 TNF 17158449 1694275 A green fluorescent protein fusion protein containing the last 100 residues of TAK1 ( TAK1-C100 ) abolished the interaction of endogenous TAB2/TAB3 with TAK1 , the phosphorylation of TAK1 , and prevented the activation of IKK and [MAPK] *induced* by IL-1 , , and RANKL . Positive_regulation MAPK9 TNF 17161959 1694545 Upon examination of the signaling components , we found that was a potent *activator* of p38 , p44/42 , p54/46 [MAPK] , and IkappaBalpha ( IkappaBalpha ) . Positive_regulation MAPK9 TNF 17172975 1679393 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the [MAPK] , and production of . Positive_regulation MAPK9 TNF 17172975 1679419 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the [MAPK] , and production of . Positive_regulation MAPK9 TNF 17189827 1680179 Stimulation of cells with *resulted* in the activation of [mitogen activated protein kinases (MAPK)] such as c-Jun N-terminal kinase (JNK) and p38 , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Positive_regulation MAPK9 TNF 17202326 1680821 Augmented lipopolysaccharide induced production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK9 TNF 17202326 1680847 In this study , we show that augmented LPS induced production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 [MAPK] . Positive_regulation MAPK9 TNF 17218473 1732529 The RhoA inhibitor C3 exoenzyme and the ROCK inhibitor Y-27632 both attenuated *induced* [MAPK] activation and blocked AR expression in HIMEC . Positive_regulation MAPK9 TNF 17220297 1703060 TRAF2 and ASK1 play essential roles in *induced* [mitogen activated protein kinase] signaling . Positive_regulation MAPK9 TNF 17258890 1725466 The effects of and FasL on GrB expression were specifically *mediated* by [p38MAPK] ( Mitogen-activated-protein-kinase ) activation . Positive_regulation MAPK9 TNF 17425653 1748790 The percentage increases in IL-18 induced phosphorylation of extracellular signal regulated kinase ( ERK ) in Th cells of NDN and DN were significantly higher than controls ( P < 0.05 ) , while the percentage increase in *induced* phosphorylation of p38 [MAPK] in monocytes and IL-18 induced phosphorylation of p38 MAPK in Th cells and monocytes were significantly higher in NDN patients than controls . Positive_regulation MAPK9 TNF 17438131 1742787 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 [MAPK] by and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation MAPK9 TNF 17438336 1749082 FAK promoted *stimulated* [MAPK] activation needed for maximal IL-6 production . Positive_regulation MAPK9 TNF 17438336 1749109 Analysis of FAK ( -/- ) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity , Tyr-397 phosphorylation , and the Pro-712/713 proline-rich region of FAK were required for *stimulated* [MAPK] activation and IL-6 production . Positive_regulation MAPK9 TNF 17446186 1749517 *increased* p38 [MAPK] phosphorylation , potently stimulated IRS-1 serine phosphorylation , and blunted insulin stimulated IRS-1 tyrosine and Akt phosphorylation and eNOS activity . Positive_regulation MAPK9 TNF 17531219 1762177 On the other hand , aloe emodin did not affect induced *activation* of p38 [mitogen activated protein kinase] or generation of reactive oxygen species . Positive_regulation MAPK9 TNF 17607712 1798196 Although *induced* the activation of p38 [MAPK] , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation MAPK9 TNF 17725582 1801641 MAC inhibited induced p38 [mitogen activated protein kinase] *activation* and cell death in cultured Schwann cells . Positive_regulation MAPK9 TNF 17895408 1823972 IA did not interfere with *induced* activation of c-Jun N-terminal kinase (JNK) and p38 [mitogen activated protein kinase] . Positive_regulation MAPK9 TNF 17942934 1814221 Deletion of NQO2 also abolished induced c-Jun NH2-terminal kinase , Akt , p38 , and p44/p42 [mitogen activated protein kinase] *activation* . Positive_regulation MAPK9 TNF 17994109 1851169 triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 [MAPK] , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation MAPK9 TNF 18039275 1828535 Further downstream in this axis of signalling , blockade *reduces* only acute bronchoconstriction , while [MAPK] inhibition abrogates completely endotoxin induced inflammation . Positive_regulation MAPK9 TNF 18060043 1853609 In cultures of Schwann cells , astrocytes , and microglia , sLRP-alpha inhibited induced *activation* of p38 [MAPK] and ERK/MAPK . Positive_regulation MAPK9 TNF 18061162 1861523 We demonstrate that *induced* proliferation of C4HD murine mammary tumor cells and of T47D cells through the activation of p42/p44 [MAPK] , JNK , PI3-K/Akt pathways and nuclear factor-kappa B (NF-kappa B) transcriptional activation . Positive_regulation MAPK9 TNF 18091748 1847374 *induced* phosphorylation of extracellular signal regulated kinase ( ERK ) and Akt , but not p38 [mitogen activated protein kinase (MAPK)] , was attenuated by nicardipine , cilnidipine , benidipine , efonidipine , and azelnidipine . Positive_regulation MAPK9 TNF 18227157 1884378 It was shown that these three proteins could ( i ) induce expression of and tissue factor and ( ii ) *induce* phosphorylation of p44/42 [mitogen activated protein kinases (MAPK)] and activation of early growth response factor 1 (Egr-1) . Positive_regulation MAPK9 TNF 18258304 1884803 However , over-expression of a dominant negative form of Rac strongly inhibited induced p42/44 [MAPK] kinase *activation* , but had little effect upon JNK and no effect upon p38 MAPK activity . Positive_regulation MAPK9 TNF 18287053 1872496 Here , we show that the murine CMV M45 protein binds to RIP1 and inhibits induced *activation* of NF-kappaB , p38 [MAPK] , and caspase independent cell death . Positive_regulation MAPK9 TNF 18287248 1896532 Flavopiridol suppresses induced *activation* of activator protein-1 , c-Jun N-terminal kinase , p38 [mitogen activated protein kinase (MAPK)] , p44/p42 MAPK , and Akt , inhibits expression of antiapoptotic gene products , and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells . Positive_regulation MAPK9 TNF 18314542 1931913 P < 0.05 ) , and MKP-1 up-regulation was temporally related to the inhibition of *induced* p38 [MAPK] phosphorylation . Positive_regulation MAPK9 TNF 18336852 1912247 *stimulated* phosphorylation of p42/p44 [MAPK] and JNK were attenuated by pretreatment with the inhibitors U0126 and SP600125 or transfection with dominant negative mutants of DeltaERK and DeltaJNK . Positive_regulation MAPK9 TNF 18364436 1912775 We , for the first time , demonstrate that binding of staphylococcal enterotoxin B to MHC-II results in activation of TNF-alpha converting enzyme , epidermal growth factor receptor , [p38MAPK] , and NF-kappaB *inducing* biphasic production . Positive_regulation MAPK9 TNF 18443205 1938533 Conversely , *induced* increases in insulin receptor substrate-1 serine phosphorylation ( Ser ( 312 ) ) , Jun NH ( 2 ) -terminal kinase phosphorylation , and extracellular signal related kinase-1/2 [mitogen activated protein kinase (MAPK)] phosphorylation were unaltered by siRNA mediated IKKbeta reduction . Positive_regulation MAPK9 TNF 18518937 1971927 Although Cot/Tpl2 was phosphorylated in IRI and in the cultured tubular epithelial cells (TEC) after stimulation with LPS and hydrogen peroxide , there were no significant differences in terms of production , neutrophil infiltration or [MAPK] *activation* between Cot/Tpl2 ( +/+ ) and Cot/Tpl2 ( -/- ) mice . Positive_regulation MAPK9 TNF 18636175 1937277 Furthermore , glucosamine inhibited the *induced* phosphorylation of [p38MAPK] and NF-kappaB p65 , and the nuclear translocation of NF-kappaB in the cells . Positive_regulation MAPK9 TNF 18653803 1960524 PMA stimulated nSMase2 translocation was independent of p38 MAPK , and neither PKC inhibitors nor small interfering RNA had significant effects on *stimulated* p38 [MAPK] activation , indicating that PKC-delta does not act through p38 MAPK in regulating nSMase2 . Positive_regulation MAPK9 TNF 18710428 2028208 As for the signalling pathway , stimulation *led* to the phosphorylation of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and p38 [mitogen activated protein kinase] ( p38MAPK ) and translocation of nuclear factor kappaB (NF-kappaB) ( p65 ) into the nuclei . Positive_regulation MAPK9 TNF 18710428 2028237 These data suggest that interaction *leads* to the phosphorylation of Erk1/2 and [p38MAPK] and nuclear translocation of NF-kappaB , which is closely associated with the production and activation of MMP-9 in cultured CC cells of HuCTT-1 and CCKS-1 . Positive_regulation MAPK9 TNF 18768892 1957240 Consistently , Nod2-null macrophages tolerant to LPS and MDP showed enhanced production of and IL-6 as well as increased NF-kappaB and [MAPK] *activation* in response to the dipeptide KF1B , the Nod1 agonist . Positive_regulation MAPK9 TNF 18948845 2053247 Hypertonic saline did not alter *induced* p38 [mitogen activated protein kinase] phosphorylation or constitutive vascular endothelial growth factor expression , suggesting that the observed inhibition is not a generalized suppression of protein phosphorylation or cellular function . Positive_regulation MAPK9 TNF 19100731 2031228 at 30 ng/ml significantly *increased* phosphorylation of receptor tyrosine kinase ( 175 kDa ) and p42 [mitogen activated protein (MAP) kinase] . Positive_regulation MAPK9 TNF 19130554 2025307 Stimulation of HIMEC with *triggered* phosphorylation of the [MAPK] , and up-regulation of VCAM-1 , FKN and ICAM-1 . Positive_regulation MAPK9 TNF 19234337 2079517 Analysis of downstream signals showed that inhibition of NAD(P)H oxidase partially inhibited NF-kappaB activation but did not reduce CCL2 mRNA stability or prevent *induced* phosphorylation of [p38MAPK] . Positive_regulation MAPK9 TNF 19275968 2072851 *stimulated* the phosphorylation levels of p38 [MAPK] , JNK , ERK1/2 and Akt in vascular endothelial cells . Positive_regulation MAPK9 TNF 19289468 2073045 The requirement for MADD was highly specific for induced *activation* of [MAPK] but not the related JNK and p38 kinases . Positive_regulation MAPK9 TNF 19371952 2081769 Of note , the IFN-gamma plus *stimulated* activation of p38 [MAPK] was suppressed following incubation with forskolin or DBcAMP alone . Positive_regulation MAPK9 TNF 19410630 2089702 By transfection of TAK1 siRNA , *induced* phosphorylation of IkappaBalpha , JNK1/2 , and [p38MAPK] , as well as IL-6 or IL-8 expression , were repressed . Positive_regulation MAPK9 TNF 19427347 2106801 *induced* the phosphorylation of p38 [mitogen activated protein (MAP) kinase] , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation MAPK9 TNF 19429670 2106877 Ang II and clearly *enhanced* ERK and [p38MAPK] phosphorylation . Positive_regulation MAPK9 TNF 19563733 2122015 Finally , EZS inhibited *induced* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phosphorylation . Positive_regulation MAPK9 TNF 19567513 2129041 [c-Jun N-terminal kinase 1/2] *activation* by induces insulin resistance in human visceral but not subcutaneous adipocytes : reversal by liver X receptor agonists . Positive_regulation MAPK9 TNF 19648110 2138338 This correlates with reduced *stimulated* p38 [MAPK] phosphorylation . Positive_regulation MAPK9 TNF 19648110 2138353 Repression of *induced* p38 [MAPK] phosphorylation , NF-kappaB dependent transcription , and IL-8 expression by dexamethasone are sensitive to transcriptional or translational inhibitors . Positive_regulation MAPK9 TNF 19648110 2138424 Thus , MKP-1 attenuates *dependent* activation of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Positive_regulation MAPK9 TNF 19648110 2138451 Small interfering RNA knockdown of dexamethasone induced MKP-1 expression partially reverses the repression of *activated* p38 [MAPK] , demonstrating that MKP-1 participates in the dexamethasone dependent repression of this pathway . Positive_regulation MAPK9 TNF 19788916 2163929 Tumor necrosis factor ( ) and H ( 2 ) O ( 2 ) *activate* [mitogen activated protein kinase (MAPK)] in SH-SY5Y cells within 5 min and this activation is completely blocked by DLPC ( 12 microM ) . Positive_regulation MAPK9 TNF 19877072 2160718 CpdA also displayed profound effects on *induced* [MAPK] activation . Positive_regulation MAPK9 TNF 19877072 2160735 In sharp contrast , DEX did not affect *induced* IKK phosphorylation , IkappaBalpha degradation , p65 nuclear translocation , or [MAPK] activation in RA FLS . Positive_regulation MAPK9 TNF 19889458 2197310 Calpain inhibition induces random migration in TNF-alpha stimulated cells and prevents the generation of reactive oxygen species , but does not alter *mediated* activation of p38 MAPK and ERK [MAPK] . Positive_regulation MAPK9 TNF 20231691 2237865 TNF-alpha treatment resulted in the phosphorylation of p38 MAPK and its downstream target , MAPK activated protein kinase-2 , but IFN-gamma did not affect the levels of [MAPK] and MAPK activated protein kinase-2 phosphorylation *induced* by . Positive_regulation MAPK9 TNF 20489729 2327427 *induced* activation of p38 [MAPK] and the production of inducible nitric oxide synthase were suppressed in ASK1-deficient Müller glial cells . Positive_regulation MAPK9 TNF 20646342 2292556 Effects of budesonide on P38 [MAPK] activation , apoptosis and IL-8 secretion , *induced* by and Haemophilus influenzae in human bronchial epithelial cells . Positive_regulation MAPK9 TNF 20646342 2292584 induced a significant *increase* in p38 [MAPK] phosphorylation . Positive_regulation MAPK9 TNF 20693316 2351485 In four of the six donors , basal and *induced* ERK and p38 [MAPK] activation were higher in ASMA than ASMNA cells . Positive_regulation MAPK9 TNF 20696856 2351516 Surprisingly , replenishment with exogenous GSH normalizes both *dependent* NF-?B as well as [MAPK] signaling and rescues hepatocytes from FKB induced death . Positive_regulation MAPK9 TNF 20951126 2364977 Taken together , this study provided first evidence demonstrating that TRAIL- , , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK9 TNF 21123734 2377729 The ability of CO to inhibit *induced* ERK1/2 and p38 [MAPK] activities in an Akt dependent manner appears to be the key element in ROS dependent survival of endothelial cells during TNF-a mediated brain inflammatory disease . Positive_regulation MAPK9 TNF 21181166 2499623 IL-1ß and *activated* the intracellular mitogen activated protein kinases ( MAPKs ) : p44/42 [MAPK] , p38 , and c-Jun N-terminal kinase (JNK) as well as nuclear factor-?B ( NF-?B ) in osteoblasts . Positive_regulation MAPK9 TNF 21285293 2425738 Inhibitors of NADPH oxidase and/or p47phox siRNA diminished ROS production and COX-2 expression as well as phosphorylation of p38 [mitogen activated protein kinase] ( p38MAPK ) and Akt *mediated* either by AS serum or by . Positive_regulation MAPK9 TNF 21336587 2457996 Effects of preconditioning with sevoflurane on *induced* permeability and activation of p38 [MAPK] in rat pulmonary microvascular endothelial cells . Positive_regulation MAPK9 TNF 21422246 2416775 Interestingly , all PHA-L ( high ) DCs displayed a strongly reduced responsiveness to induced [p38-MAPK] *activation* compared with PHA-L ( low ) DCs , indicating differences in PHA-L binding capacities between DCs with different inflammatory properties . Positive_regulation MAPK9 TNF 21422246 2416789 Moreover , hybrid-type , but not complex-type , N-glycans are required for *induced* [p38-MAPK] activation and subsequent phenotypic maturation of BMDCs ( MHC-II , CD86 , CCR7 upregulation ) . Positive_regulation MAPK9 TNF 21520062 2423128 Here , we report that *induced* cPLA(2) protein and mRNA expression , PGE ( 2 ) production , and phosphorylation of p42/p44 MAPK , p38 [MAPK] , and JNK1/2 , which were attenuated by pretreatment with a ROS scavenger [ N-acetyl-L-cysteine , ( NAC ) ] and the inhibitors of NADPH oxidase [ apocynin (APO) and diphenyleneiodonium chloride ( DPI ) ] , MEK1/2 ( U0126 ) , p38 MAPK ( SB202190 ) , and JNK1/2 ( SP600125 ) or transfection with siRNA of Nox2 , p47(phox) , MEK1 , p42 , p38 , or JNK2 . Positive_regulation MAPK9 TNF 21545687 2554387 significantly *induced* phosphorylation of p38 [MAPK] , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation MAPK9 TNF 21894146 2510891 Vehicle and untreated NTN exhibited heavy proteinuria and glomerular thrombosis at 24 h with P-selectin and fibrin immunostaining within capillaries , glomerular macrophage and T cell infiltration , *activation* of JNK and p38 [MAPK] signalling , and upregulation of glomerular mRNA levels of pro-inflammatory molecules ( , NOS2 , MMP-12 and CCL2 ) . Positive_regulation MAPK9 TNF 22002864 2526334 These results suggest that H ( 2 ) O ( 2 ) -induced secretion of *increases* apoptosis of cardiac myocytes through ROS dependent activation of p38 [MAPK] . Positive_regulation MAPK9 TNF 22227193 2544583 Casuarinin significantly inhibited *induced* activation of NF-?B , STAT1 , and p38 [MAPK] . Positive_regulation MAPK9 TNF 22230399 2519483 KMUP-1 inhibited *induced* iNOS and U46619 induced PDE-5A and phospho-p38 [MAPK] in normoxia , confirming its anti-proinflammatory action . Positive_regulation MAPK9 TNF 22250084 2551218 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Positive_regulation MAPK9 TNF 22343222 2617835 Using immunohistological techniques , we showed a higher epithelial expression of , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator [protein-1/mitogen activated protein kinase] signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation MAPK9 TNF 22525504 2522579 *up-regulated* the phosphorylation levels of p38 [MAPK] and increased the translocation of NF-kB p65 protein into the nucleus , also proved by immunofluorescence staining . Positive_regulation MAPK9 TNF 22526394 2595920 also *increased* the production of inducible nitric oxide synthase (iNOS) , nitric oxide ( NO ) , and intercellular adhesion molecule 1 ( ICAM-1 ) through activation of p38 [mitogen activated protein kinase (MAPK)] from HT-29 cells . Positive_regulation MAPK9 TNF 22773691 2659909 induced *activation* of p38 [MAPK] and NF-?B was attenuated by miR-140-3p mimic . Positive_regulation MAPK9 TNF 22819264 2646102 CORM-2 inhibited *induced* activation of p38 [MAPK] , ERK1/2 , JNK , and NF-?B signaling pathways in HUVECs . Positive_regulation MAPK9 TNF 22947346 2678668 *induced* phosphorylated p38 [mitogen activated protein kinase] levels were increased in ASMCs from patients with severe asthma compared with those from patients with nonsevere asthma and nonasthmatic subjects , whereas TNF-a induced phosphorylated c-Jun N-terminal kinase and phosphorylated extracellular signal related kinase levels were increased in all asthmatic groups . Positive_regulation MAPK9 TNF 22988345 2674362 The EGF receptor and HER2 participate in *dependent* [MAPK] activation and IL-8 secretion in intestinal epithelial cells . Positive_regulation MAPK9 TNF 22988345 2674390 As the epidermal growth factor receptor (EGFR) is a known transducer of proliferative signals and a potent activator of MAPKs , we hypothesized that the EGFR participates in dependent [MAPK] *activation* and IL-8 secretion by intestinal epithelial cells ( IECs ) . Positive_regulation MAPK9 TNF 23071098 2720919 Mixed-effects modeling analysis of our data was vital for ascertaining that IL-1a and TGF-a treatment increased the activities of more pathways than IL-6 and TNF-a and that TGF-a and *increased* p38 [MAPK] and c-Jun N-terminal kinase (JNK) phospho-protein levels in a synergistic manner . Positive_regulation MAPK9 TNF 23142559 2722793 Western blot analysis revealed that pilocarpine and physostigmine enhanced the *induced* phosphorylation of ERK1/2 and p38 [MAPK] and the degradation of I?Ba . Positive_regulation MAPK9 TNF 23333920 2758391 Interestingly , IL-27 promoted the basal and enhanced *induced* phosphorylation of p38 [MAPK] and Akt , but not I?Ba . Positive_regulation MAPK9 TNF 23353699 2754247 We further demonstrated that markedly *stimulated* p38 MAPK , p42/p44 [MAPK] , and JNK1/2 phosphorylation via a c-Src/EGFR , PDGFR/PI3K/Akt pathway . Positive_regulation MAPK9 TNF 23354775 2770639 p38a [mitogen activated protein kinases (MAPK)] may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , , interleukin-1ß , and oxidative stress . Positive_regulation MAPK9 TNF 23664593 2838390 sFGL2 secretion by CD4 ( + ) T cells can be *induced* with and IFN-? stimulation through [MAPK] signaling in renal allograft AR . Positive_regulation MAPK9 TNF 23861542 2817269 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Positive_regulation MAPK9 TNF 23884101 2821475 Furthermore , P. vulgaris extract suppressed *induced* phosphorylation of p38 [mitogen activated protein kinase (MAPK)] and extracellular signal regulated kinase ( ERK ) . Positive_regulation MAPK9 TNF 23935096 2840779 In contrast , loss of SK1 prevented *induced* phosphorylation of p38 [MAPK] , and inhibition of p38 MAPK , like SK1 knockdown , also potentiates RANTES induction . Positive_regulation MAPK9 TNF 24069158 2847000 We showed that markedly *stimulated* p42/p44 MAPK , p38 [MAPK] , and JNK1/2 phosphorylation which were attenuated by their respective inhibitors . Positive_regulation MAPK9 TNF 24080497 2902546 Consistently , DUSP1 promotes apoptosis and decreases NF-?B activity in cells in which p38 [MAPK] is *induced* by treatment . Positive_regulation MAPK9 TNF 24089494 2848157 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed receptor 1 and *requires* activation of p38 [MAPK] , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation MAPK9 TNF 24361597 2911252 We further demonstrated that *stimulated* ERK1/2 , p38 [MAPK] , and JNK1/2 phosphorylation via a c-Src dependent PDGFR/PI3K/Akt pathway . Positive_regulation MAPK9 TNF 24378531 2911780 TRAF2 has been previously reported to be required for induced *activation* of p38 [MAPK] . Positive_regulation MAPK9 TNF 24441870 2922940 We showed that markedly *stimulated* Jak2 , PDGFR , Akt , and p42/p44 [MAPK] phosphorylation , which were attenuated by their respective inhibitors . Positive_regulation MAPK9 TNF 24441870 2922958 In addition , *induced* p42/p44 [MAPK] phosphorylation was reduced by AG1296 or LY294002 . Positive_regulation MAPK9 TNF 24441870 2922994 On the other hand , could *induce* Akt and p42/p44 [MAPK] translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation MAPK9 TNF 24446489 2912945 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Positive_regulation MAPK9 TNF 24489443 2884799 Finally , by investigating the intracellular pathways involved in promoting the VEC release of cytokines/chemokines , which are targeted by natural anti-inflammatory compounds , we documented that aLipoic acid significantly counteracted *induced* NF-?B and [p38/MAPK] activation while the effects of Ginkgo biloba appeared to be predominantly mediated by Akt . Positive_regulation MAPK9 TNF 24750790 2936590 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas and NO production *required* all three [MAPK] . Positive_regulation MAPK9 TNF 7689564 225771 *induced* activation and increased tyrosine phosphorylation of [mitogen activated protein (MAP) kinase] in human fibroblasts . Positive_regulation MAPK9 TNF 7689564 225784 induced *activation* of [MAPK] was demonstrated by its enhanced ability to phosphorylate myelin basic protein in vitro and by a characteristic shift in the electrophoretic mobility of MAPK proteins . Positive_regulation MAPK9 TNF 7722327 301764 *induces* tyrosine phosphorylation of [mitogen activated protein kinase] in adherent human neutrophils . Positive_regulation MAPK9 TNF 7722327 301790 PMN pretreatment with genistein , a tyrosine kinase inhibitor , inhibited the *induced* increase in tyrosine phosphorylation and [MAPK] activity . Positive_regulation MAPK9 TNF 8626494 360283 Inhibition of induced p42/p44 [mitogen activated protein kinase] *activation* by sodium salicylate . Positive_regulation MAPK9 TNF 8626494 360297 *activates* both p42 and p44 [mitogen activated protein kinases (MAPK)] in human FS-4 fibroblasts , cells for which TNF is mitogenic . Positive_regulation MAPK9 TNF 8626494 360310 We now show that *activates* p42 [MAPK] in two cell lines whose growth is inhibited by TNF . Positive_regulation MAPK9 TNF 8626494 360325 We now show that neither phorbol ester-sensitive protein kinase C nor Gialpha link TNF to p42/p44 MAPK activation , because pretreatment of FS-4 cells with phorbol ester to down-regulate protein kinase C or pretreatment with pertussis toxin to block Gialpha does not inhibit p42/p44 [MAPK] *activation* by . Positive_regulation MAPK9 TNF 8626494 360354 To further analyze MAPK activation in FS-4 cells , we compared p42/p44 [MAPK] *activation* by and epidermal growth factor (EGF) . Positive_regulation MAPK9 TNF 8626494 360370 Elucidation of the mechanism whereby sodium salicylate blocks *induced* p42/p44 [MAPK] activation may help to clarify TNF activated signaling pathways . Positive_regulation MAPK9 TNF 8662702 367189 additionally *caused* rapid p38 and JNK-1 [mitogen activated protein kinase] activation and efficient NF-kappaB translocation , which could not be achieved even by high levels of ceramide . Positive_regulation MAPK9 TNF 9106254 424427 The increases in [MAPK] *induced* by and IL-1 were similar to the increases induced by PMA and PDGF-AB . Positive_regulation MAPK9 TNF 9106254 424453 Our findings indicate that and IL-1 activate parallel signal transduction pathways in human neuroma fibroblasts , and that they are relatively stronger *activators* of [MAPK] than of SAPK . Positive_regulation MAPK9 TNF 9315666 456107 , an inhibitor of insulin stimulated adipogenesis , *activated* [MAPK] in 3T3-L1 cells . Positive_regulation MAPK9 TNF 9439626 482876 *increased* ERK1 and ERK2 [MAPK] phosphorylation . Positive_regulation MAPK9 TNF 9439626 482902 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic effect of *requires* protein tyrosine phosphorylation and [MAPK] activation . Positive_regulation MAPK9 TNF 9593119 505492 The CAZ released endotoxin was similar to purified LPS with respect to the following biological activities in LPS-responsive C3H/HeN mice and LPS-hyporesponsive C3H/HeJ mice : lethal toxicity in GalN sensitized mice , in vitro induction of and NO production by macrophages , and [mitogen activated protein kinase] *activation* in macrophages . Positive_regulation MAPK9 TNF 9766635 538522 Our data suggest that and GM-CSF *activate* ERKs and p38 [MAPK] by different signal transduction pathways . Positive_regulation MAPK9 TNF 9770326 538809 Furthermore , *induction* of p42/p44 ERK and [p38-MAPK] phosphorylation , c-jun kinase activation , and IkappaBalpha degradation were normal . Positive_regulation MAPK9 TNF 9883899 558215 *Activation* of p42/p44 [mitogen activated protein kinases (MAPK)] and p38 MAPK by is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation MAPK9 TNF 9883899 558230 Here , we demonstrate that is *sufficient* to activate p42/p44 MAPK and p38 [MAPK] . Positive_regulation MAPK9 TNF 9930718 588844 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Positive_regulation MAPK9 TNF 9931102 588911 ( 100 U/mL ) transiently *activated* [MAPK] with a maximal induction 10 minutes after stimulation that returned to baseline levels by 2 hours after treatment . Positive_regulation MAPK9 TNF 9931102 588924 PD98059 also blocked *stimulated* [MAPK] activation in a concentration dependent manner , which is consistent with its inhibition of TNF-alpha directed migration . Positive_regulation MAPK9 TNF 9931102 588937 To identify which TNF-alpha receptor is involved in *induced* [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Positive_regulation MAPK9 TNF 9931102 588963 VSMC express both receptors , but induced [MAPK] *activation* was inhibited only by the TNF-R1 antibody . Positive_regulation MAPK9 TNF 9931102 588989 Both TRO and RSG inhibited migration , but neither attenuated *induced* [MAPK] activation , indicating that their antimigration activity was exerted downstream of MAPK . Positive_regulation MAPK9 TNFSF10 12969966 1185578 Among the intracellular pathways investigated , significantly *stimulated* the extracellular signal regulated kinase 1/2 ( ERK1/2 ) but not the [p38/mitogen activated protein kinase (MAPK)] or the c-Jun NH2-terminal kinase (JNK) pathway . Positive_regulation MAPK9 TNFSF10 20951126 2364978 Taken together , this study provided first evidence demonstrating that , TNF-a- , and p53 mediated damnacanthal *induced* apoptosis require the activation of p38 [MAPK] and mitochondrion mediated caspase dependent pathways . Positive_regulation MAPK9 TNFSF10 21152872 2373400 Taken together , we show herein that the upstream molecule of the induced [MAPK] *activation* is MEKK , as opposed to ASK1 , via the mediation of its signal through JNK/p38 in a caspase-8 dependent manner . Positive_regulation MAPKAPK2 EPHB2 14499342 1143732 phosphorylated MK2 in vitro and *activated* [MK2] in f-methionyl-leucyl-phenylalanine ( FMLP ) -stimulated neutrophils . Positive_regulation MAPKAPK2 MAP2K6 10816593 714758 ( Glu ) also *induced* p38 dependent activation of the downstream MAPK activated protein kinase , [MAPKAP-K2] , and the phosphorylation of alphaB-crystallin on serine-59 . Positive_regulation MAPKAPK2 TNF 18486623 1927793 stimulation *induced* p38 MAPK dependent phosphorylation of [MK2] and HSP27 . Positive_regulation MAPKAPK2 TNF 20231691 2237866 TNF-alpha treatment resulted in the phosphorylation of p38 MAPK and its downstream target , MAPK activated protein kinase-2 , but IFN-gamma did not affect the levels of MAPK and [MAPK activated protein kinase-2] phosphorylation *induced* by . Positive_regulation MAPKAPK2 TNF 7759569 307809 [MAPKAP kinase 2] is *activated* by heat shock and : in vivo phosphorylation of small heat shock protein results from stimulation of the MAP kinase cascade . Positive_regulation MAPKAPK2 TNF 9754715 535210 *stimulated* activation of p38 MAP kinase , and [MAPKAP kinase-2] , a known downstream target of p38 MAP kinase , was strongly inhibited by pre-incubation with the p38 MAP kinase inhibitor SB203580 , whereas the minor activation of p42/44 MAP kinase was abolished by pre-incubation of the cell with the novel MAP kinase kinase 1 inhibitor PD098059 . Positive_regulation MAPKAPK3 EPHB2 8943323 399827 In vitro characterization of the kinase revealed that [3pK] is *activated* by . Positive_regulation MAPKAPK3 MAP2K6 11328854 808032 In contrast , we observed sustained luteal-phase CREB phosphorylation in vivo , consistent with upstream MAPK activation and [MAPKAPK-3] *induction* . Positive_regulation MAPRE1 STK39 18083840 1837347 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation MAPRE2 NES 12403791 1036216 We have also found that a previously described double ( amino acids 213-236 ) does not *mediate* the nuclear shuttling of [EB2] , but is an interaction domain with the cellular export factor REF in vitro . Positive_regulation MAPT TGM2 11089576 751462 However , *induced* cross linking of [PHF-tau] was observed in AD and thus may also contribute to the formation of NFT in other neurodegenerative disorders including PSP . Positive_regulation MARCKS CAPN8 14720464 1181764 Myoblast migration is prevented by a *dependent* accumulation of [MARCKS] . Positive_regulation MARCKS IL1B 9666341 518586 Only AVP and PMA , but not , *caused* an increase in [MARCKS] phosphorylation . Positive_regulation MARCKS TNF 1860846 163951 The human cDNA was used to demonstrate that could rapidly *stimulate* [MARCKS] gene transcription in the human promyelocytic leukemia cell line HL60 . Positive_regulation MARCKSL1 HES2 16247329 1471592 *had* no effect on the normal [f-MLP] dose dependent increase in PMN activation . Positive_regulation MARCKSL1 ITGB2 10497314 647531 However , phosphorylated [MacMARCKS] alone could not *induce* mediated cell-cell adhesion unless phorbol esters were added , suggesting that the phosphorylation of other proteins might also be involved . Positive_regulation MARCO TLR7 16525990 1541886 We propose that the *dependent* induction of [MARCO] by innate immune stimulation enhances recognition and uptake of pathogenic organisms such as NM , thus contributing to host defence against infection . Positive_regulation MARK1 DAPK1 21311567 2463458 *activates* [MARK1/2] to regulate microtubule assembly , neuronal differentiation , and tau toxicity . Positive_regulation MASP1 IL1B 12356684 993993 Transient expression of constructs of these genes fused to the luciferase reporter gene confirmed their liver-specific expression and showed that the [MASP] promoters were slightly *up-regulated* by the presence of . Positive_regulation MASP2 IL1B 12356684 993994 Transient expression of constructs of these genes fused to the luciferase reporter gene confirmed their liver-specific expression and showed that the [MASP] promoters were slightly *up-regulated* by the presence of . Positive_regulation MAST1 IL1B 17607547 1765385 [Mast] cell activation *induced* expression in particular in nearby CD68 positive synovial macrophages . Positive_regulation MAST1 IL1B 18554961 1946021 This study suggests that MTA induces NM via a mechanism dependent on [MAST] and MO *mediated* by , MIP-2 , and LTB ( 4 ) . Positive_regulation MAST2 IL1B 17607547 1765386 [Mast] cell activation *induced* expression in particular in nearby CD68 positive synovial macrophages . Positive_regulation MAST2 IL1B 18554961 1946024 This study suggests that MTA induces NM via a mechanism dependent on [MAST] and MO *mediated* by , MIP-2 , and LTB ( 4 ) . Positive_regulation MAST3 IL1B 17607547 1765387 [Mast] cell activation *induced* expression in particular in nearby CD68 positive synovial macrophages . Positive_regulation MAST3 IL1B 18554961 1946027 This study suggests that MTA induces NM via a mechanism dependent on [MAST] and MO *mediated* by , MIP-2 , and LTB ( 4 ) . Positive_regulation MAST4 IL1B 17607547 1765388 [Mast] cell activation *induced* expression in particular in nearby CD68 positive synovial macrophages . Positive_regulation MAST4 IL1B 18554961 1946030 This study suggests that MTA induces NM via a mechanism dependent on [MAST] and MO *mediated* by , MIP-2 , and LTB ( 4 ) . Positive_regulation MAT2A TNF 14530285 1174843 , which activates both NF-kappa B and AP-1 , *increased* [MAT2A] expression in a dose- and time dependent manner , binding of both NF-kappa B and AP-1 to the MAT2A promoter and MAT2A promoter activity , with the latter effect blocked by site directed mutagenesis of the NF-kappa B and AP-1 binding sites . Positive_regulation MAT2A TNF 14530285 1174846 Blocking NF-kappa B with I kappa B super-repressor or AP-1 with dominant negative c-Jun led to decreased basal MAT2A expression and prevented the *induced* increase in [MAT2A] expression . Positive_regulation MAT2A TNF 17451794 1772133 TB-2-081 , and to a lesser extent TB-2-082 , suppressed IL-6 induced alpha1-antichymotrypsin (AACT) mRNA expression in HepG2 cells , whereas TB-2-081 failed to influence the mRNA expression of the *induced* mRNA expression of the [methionine adenosyltransferase 2A] gene in these cells . Positive_regulation MATK TNFSF10 18955500 2014778 Together , our findings suggest that nuclear *activation* of [Chk2] by acts as a positive feedback loop involving the mitochondrion dependent activation of caspases , independently of p53 . Positive_regulation MATN1 GNE 21436238 2448070 These findings indicate that sialuria mutated rat effectively *increases* the intracellular [CMP-sialic] acid level . Positive_regulation MATN2 BMP7 18328806 1891932 *dependent* expression of [matrilin-2] is involved in keratinocyte migration in response to wounding . Positive_regulation MATN2 BMP7 18328806 1891934 Intriguingly , which is one of DeltaNp63-target gene products , *induced* [matrilin-2] and attenuated inhibitory effect of siRNA against DeltaNp63 on matrilin-2 . Positive_regulation MB21D1 TNF 8672935 343137 Il-1 and *increased* biosynthesis of [holo-hCG as] well as the free alpha- and free beta-subunit and the beta-core protein . Positive_regulation MBD2 IL1B 16847181 1588141 The messenger RNA expressions of [LARC] ( liver and activation regulated chemokine ) , GMCSF ( granulocyte-macrophage colony stimulating factor ) , epiregulin , ICAM1 ( intercellular adhesion molecule 1 ) , and TGFA ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation MBD2 SYNM 6790803 16524 The mothers ' livers were also less responsive to [demethylase] *induction* by PCB 's during the last 5 days of gestation in comparison with the response earlier in pregnancy or just after delivery . Positive_regulation MBD2 SYNM 7379044 11358 Only L-tryptophan *induces* [DMN-demethylase] I and only L-tryptophan and 3-indolylmethanol induce II , representing a doubling of enzyme activity in all 3 instances . Positive_regulation MBD3 IL1B 16847181 1588143 The messenger RNA expressions of [LARC] ( liver and activation regulated chemokine ) , GMCSF ( granulocyte-macrophage colony stimulating factor ) , epiregulin , ICAM1 ( intercellular adhesion molecule 1 ) , and TGFA ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation MBL2 EDN2 15860794 1425764 [MBP1] *induced* activation of neural nuclear factor (NF)-kappaB , from 10 min to 12 h , declining by 24 h , whereas induced a short lived activation of NF-kappaB . Positive_regulation MBL2 TNF 10898508 712104 Studying the functional consequences of the interaction , we found that the release of from Mphi is *induced* by C1q but not by [MBL] . Positive_regulation MBP EDN2 2201205 140447 ( 0.07-1.4 nmol/kg iv ) *induced* a long lasting increase in [mean blood pressure (MBP)] and a decrease in renal blood flow ( RBF ) . Positive_regulation MBP EDN2 2201205 140453 Thus the regression line representing the relationship between *induced* changes in [MBP] and RBF was steeper in rats given nifedipine ( slope : vehicle , -1.33 ; nifedipine , -5.50 ; Positive_regulation MBP EPHB2 22627361 2604315 Furthermore , [MBP] *induced* the phosphorylation of the extracellular signal regulated kinase ( ) 1/2 , p38 mitogen activated protein kinase (MAPK) , Jun-N-terminal protein kinase (JNK) , and signal transducer and activator of transcription ( STAT ) 3 in the infected cells . Positive_regulation MBP EPHB2 9636029 513317 Interestingly , the peptide also showed some ability to inhibit *mediated* phosphorylation of [myelin basic protein] , but was inactive as an inhibitor of the unrelated kinases Raf , Abl , and PKA . Positive_regulation MBP IFI27 17403142 1735791 Our previous studies have found that expression of in oligodendrocytes *enhances* [myelin basic protein (MBP)] gene expression through a mechanism that involves the transcription factor Sp1 . Positive_regulation MBP IFI27 17403142 1735792 In an effort to identify other cofactors that are involved in the *mediated* activation of [MBP] gene expression , a yeast two-hybrid assay was performed using an N-terminal truncated p27 and a mouse embryo cDNA library . Positive_regulation MBP MAP2K6 18053806 1846680 Furthermore , when an immunoprecipitated active MEK was incubated with nobiletin under cell-free conditions , nobiletin was found to inhibit the *mediated* [MBP] phosphorylation . Positive_regulation MBP PGC 21715619 2447225 Chromatin immunoprecipitations revealed the recruitment of PGC1a to MBP promoter in mouse brain , and PGC1a over-expression increased MBP and SREBP-2 promoter activity , suggesting that *regulates* [MBP] and cholesterol synthesis at the transcriptional level . Positive_regulation MBP TF 12401963 1009361 *regulates* transcription of the [MBP] gene and its action synergizes with IGF-1 to enhance myelinogenesis in the md rat . Positive_regulation MBP TNF 1281478 205702 The *stimulated* [myelin basic protein] kinases-1 and -2 were identified as extracellular signal regulated kinases-2 and -1 , respectively , based on their elution pattern on Mono Q chromatography , their inactivation by protein phosphatase action , their reaction with phosphothreonine and phosphotyrosine antibodies , and by their migration on sodium dodecyl sulfate-polyacrylamide gel electrophoresis as 42- and 44-kDa proteins recognized by anti-extracellular signal regulated kinase antibodies . Positive_regulation MBP TNF 14769150 1182393 IFN-gamma ( 100 U/ml ) and ( 1000 U/ml ) or IL-5 ( 200 pM ) *caused* a significant increase in the expression of the eosinophil peroxidase (EPO) and the [major basic protein (MBP)] genes . Positive_regulation MBP TNF 18397264 1958068 The [MBP] *induced* a dose dependent release of interferon-gamma (IFN-gamma) , and interleukin-10 (IL-10) by patient derived MNCs . Positive_regulation MBS1 AXIN2 17373666 1741397 To study the functional *role* of in [MBs] , wild-type AXIN2 was overexpressed in MB cell lines in which the Wnt signaling pathway was activated by Wnt-3a . Positive_regulation MBTPS1 ABCG2 20110355 2226722 E ( 2 ) -induced [S1P] and dihydro-S1P export required estrogen receptor-alpha , not GPR30 , and was *suppressed* either by pharmacological inhibitors or gene silencing of ABCC1 ( multidrug resistant protein 1 ) or ( breast cancer resistance protein ) . Positive_regulation MBTPS1 CTGF 15862293 1400935 However , the mechanism by which [S1P] *induces* expression is unknown . Positive_regulation MBTPS1 CTGF 15862293 1400938 We also showed by luciferase reporter assays and chromatin immunoprecipitation that [S1P] *induces* expression via Smad activation as TGF-beta does . Positive_regulation MBTPS1 CTGF 22422617 2588077 Furthermore , [S1P] stimulation *induced* expression of in a dose dependent manner that was markedly inhibited by blocking the ERK1/2 and JNK signaling pathways . Positive_regulation MBTPS1 EPHB2 12138095 991530 Cell survival relied on two pertussis toxin-sensitive events , activation of and *activation* of phosphatidylinositol 3-kinase (PI3K)/Akt by [S1P] . Positive_regulation MBTPS1 EPHB2 12665551 1074804 In addition , we found that [S1P] *induces* the sustained activation of and the subsequent degradation of microphthalmia associated transcription factor ( MITF ) , which plays a key role in melanogenesis . Positive_regulation MBTPS1 EPHB2 14608042 1162194 Finally , the [S1P] *activation* of and inhibition of apoptosis were reduced by pertussis toxin treatment , suggesting that G-protein coupled receptors , such as the endothelial differentiation gene ( EDG ) receptor , play a role . Positive_regulation MBTPS1 EPHB2 17306937 1705225 Pharmacological inhibitors of and p38 but not JNK partly *inhibited* [S1-P] induction of IL-8 mRNA levels . Positive_regulation MBTPS1 EPHB2 19077254 2003168 LPA and [S1P] also *induce* p44/42 MAP kinase phosphorylation in these cells and stimulate cell proliferation via G i/o coupled receptors in an Epidermal Growth Factor Receptor (EGFR)- and ERK dependent pathway . Positive_regulation MBTPS1 EPHB2 19433984 2096474 [S1P] stimulation of ERK was completely *inhibited* by an S1P1/3 subtype receptor antagonist ( VPC23019 ) , by a Gi protein inhibitor ( pertussis toxin ) and by a mitogen activated protein kinase inhibitor ( PD98059 ) . Positive_regulation MBTPS1 EPHB2 19433984 2096503 Thus , exogenous [S1P] *induces* rapid and reversible S1P1 mediated phosphorylation . Positive_regulation MBTPS1 EPHB2 20008963 2217582 Further study revealed that both MDG-1 and [S1P] *induce* Akt and phosphorylation in a dose- and time dependent manner , an effect that is attenuated by pre-treatment with either the Akt inhibitor wortmannin or the ERK inhibitor PD98059 , and MDG-1 can also induce eNOS phosphorylation and increases in production of NO . Positive_regulation MBTPS1 FAS 20651091 2322114 [S1P] , but not carbachol , *induces* the expression of interleukin-6 and . Positive_regulation MBTPS1 HBEGF 10354366 617776 Similar transfection with Edg-3 plus -5 antisense plasmids suppressed Tsup-1 cell levels of immunoreactive Edg-3 and -5 , but not Edg-2 or -4 , and concurrently reduced [S1P-] , but not LPA- , *induced* Tsup-1 cell increases in both and susceptibility to DT . Positive_regulation MBTPS1 MAP2K6 12197778 981927 Although inhibition *prevented* [S-1-P] activation of ERK1 and ERK2 and slightly but significantly inhibited basal Caco-2 proliferation , MEK inhibition did not block the S-1-P mitogenic effect . Positive_regulation MBTPS1 MAP2K6 20979115 2479939 PD98059 , a inhibitor , and pertussis toxin , a Gi inhibitor , *attenuated* HDL- , [S1P-] , and rHDL-S1P induced Stat3 phosphorylation , whereas LY294002 , a PI3K inhibitor , had no effect . Positive_regulation MBTPS1 PECAM1 18502612 1928184 In this study , we demonstrated that [S1P] *induced* tyrosine phosphorylation in human umbilical cord vein cells ( HUVECs ) . Positive_regulation MBTPS1 PLAU 19147534 2026255 [S1P] *induced* expression of and its receptor , uPAR , in GBM cells . Positive_regulation MBTPS1 RGS16 19374869 2065548 The present study demonstrates that [S1P] *induces* RGS2 and mRNA expression but uses distinct S1P receptor subtypes and signalling pathways to regulate expression of these RGS proteins . Positive_regulation MBTPS1 RGS2 19374869 2065549 The present study demonstrates that [S1P] *induces* and RGS16 mRNA expression but uses distinct S1P receptor subtypes and signalling pathways to regulate expression of these RGS proteins . Positive_regulation MBTPS1 S1PR3 10220556 609245 When H218 and were stably expressed in rat HTC4 hepatoma cells , [S1P] *induced* Ca2+ responses with nanomolar EC50 values . Positive_regulation MBTPS1 S1PR3 10354366 617778 Similar transfection with Edg-3 plus -5 antisense plasmids suppressed Tsup-1 cell levels of immunoreactive and -5 , but not Edg-2 or -4 , and concurrently reduced [S1P-] , but not LPA- , *induced* Tsup-1 cell increases in both HB-EGF and susceptibility to DT . Positive_regulation MBTPS1 S1PR3 18172456 1903369 The data indicate that LPA and S1P potently increase [ Ca ( 2+ ) ] ( i ) in human keratinocytes and that the effect of LPA is mediated by LPA ( 2 ) , whereas that of [S1P] is *mediated* at least to a large part by . Positive_regulation MBTPS1 S1PR3 18472021 1951645 However , our recent work indicates that overexpressed SPHK1 is involved in cardiomyocyte degeneration and fibrosis in vivo , in part through [S1P] *activation* of the signaling . Positive_regulation MBTPS1 S1PR3 21256191 2398043 This event is mediated by S1P(1) and receptors by Gi proteins and can *contribute* to [S1P] mitogenic signaling . Positive_regulation MBTPS1 S1PR3 21420933 2421611 The *activation* of SUR2/Kir6.1 channel by [S1P] via stimulated cell proliferation and decreased IL-6 and collagen secretions . Positive_regulation MBTPS1 S1PR3 21920544 2584987 [S-1-P] mediated VSMC migration is modulated by a G-protein coupled src pathway partially through src mediated p38 ( MAPK ) and JNK signaling and *requires* S-1-PR1 and receptors . Positive_regulation MBTPS1 SPHK1 12441135 1017079 Enforced expression of *increased* [S1P] levels and blocked MCF-7 cell death induced by anti-cancer drugs , sphingosine , and TNF-alpha . Positive_regulation MBTPS1 SPHK1 15485866 1347366 Adenovirally expressed *led* to a 2-fold increase of endogenous [S1P] and to increased TIMP-1 mRNA and protein production . Positive_regulation MBTPS1 SPHK1 16575915 1550167 We show that TNFalpha rapidly triggers [S1P] generation and *activation* of . Positive_regulation MBTPS1 SPHK1 17904858 1812318 Activation of by any of a variety of agonists *increases* [S1P] levels , which in turn can function intracellularly as a second messenger or in an autocrine and/or paracrine fashion to activate and signal through S1P receptors present on the surface of the cell . Positive_regulation MBTPS1 SPHK1 18258856 1884871 Adenoviral expression of in the liver of Sphk1 ( -/- ) mice *restored* plasma [S1P] levels . Positive_regulation MBTPS1 SPHK1 19168577 2048969 This suggested that , in vascular injury , S1P generated by SphK2 activation plays a distinctly separate role compared with *dependent* [S1P] generation and survival signaling . Positive_regulation MBTPS1 SPHK1 20234131 2237959 We previously showed that the inhalational anesthetic isoflurane protects against renal ischemia reperfusion injury in part via *mediated* synthesis of [sphingosine-1-phosphate (S1P)] . Positive_regulation MBTPS1 SPHK1 21660960 2442632 Interestingly , exogenously added [S1P] *induced* significant up-regulation of and the synthesis of additional S1P , and expression of S1PR1 ,3 , but not S1PR2 . Positive_regulation MBTPS1 SPHK1 21848514 2510097 However , inhibition did *diminish* EGF ( epidermal growth factor ) -driven increases in [S1P] levels and Akt ( also known as protein kinase B ) /ERK ( extracellular-signal regulated kinase ) phosphorylation . Positive_regulation MBTPS1 SPHK1 23933064 2845044 These results suggest an important role for *mediated* [S1P] signaling regulated ROS in the development of hyperoxia induced lung injury in a murine neonatal model of bronchopulmonary dysplasia . Positive_regulation MBTPS1 SPHK1 24069553 2847174 Recent findings published by Liang et al. in Cancer Cell demonstrate that *mediated* upregulation of [sphingosine-1-phosphate (S1P)] drives a persistent NF?B/IL-6/STAT3/sphingosine-1-phosphate receptor 1 ( S1PR1 ) amplification loop that is critical to the development of chronic colitis and colitis associated cancer . Positive_regulation MBTPS1 TNF 16529909 1598054 Furthermore , infection of human bronchial epithelial cells ( HBEpC ) with RSV A-2 virus increased SK1 mediated synthesis of DHS1P and S1P , whereas *enhanced* only [S1P] production in HPAEC . Positive_regulation MBTPS1 TNF 16575915 1550168 We show that rapidly *triggers* [S1P] generation and activation of SPHK . Positive_regulation MBTPS1 TNF 16936207 1609013 In cultured adipocytes , ceramide , sphingosine , and [S1P] *induced* gene expression of plasminogen activator inhibitor-1 , , monocyte chemoattractant protein-1 , interleukin-6 , and keratinocyte derived chemokine . Positive_regulation MBTPS1 TNF 21537466 2361762 Activation of various plasma membrane receptors , such as the formyl methionyl leucyl phenylalanine receptor , C5a receptor , and a receptor , *leads* to a rapid increase in intracellular [S1P] level via SphK stimulation . Positive_regulation MCAM IGFBP1 11934254 927779 Transforming growth factor beta ( TGF-beta ) , decorin ( a proteoglycan in the ECM ) , and [melanoma cell adhesion molecule] ( Mel-CAM ) inhibit , and insulin-like growth factor II (IGF-II) , , and endothelin 1 (ET-1) *stimulate* EVT cell migration/invasion . Positive_regulation MCAM TNF 19229070 2054635 *enhanced* [CD146] expression at the junction and apical membrane of human umbilical veins endothelial cells ( HUVECs ) through CD146 synthesis and intracellular store redistribution . Positive_regulation MCAM TNF 19229070 2054636 Our results demonstrate that [CD146] is *regulated* by the inflammatory cytokine and that CD146 and sCD146 are both involved in monocyte transendothelial migration during inflammation . Positive_regulation MCC TNF 11746260 889078 Surprisingly , [MCC] also directly *induced* the synthesis of IL-12 and GM-CSF , but not , by LNCaP cells . Positive_regulation MCL1 EPHB2 16761109 1585441 With PMA , *stimulated* [MCL1] mRNA expression and ML-1 cell differentiation , and ERK additionally stabilized expression of the MCL1 protein . Positive_regulation MCL1 EPHB2 16761109 1585442 However , with MTDAs , transient and ensuing JNK activation *contributed* to initial [MCL1] upregulation and viability-retention , but sustained JNK activation eventually resulted in cell death . Positive_regulation MCL1 EPHB2 18676833 1943482 Moreover , Pin1 is also required for the *up-regulation* of [Mcl-1] by activation . Positive_regulation MCL1 EPHB2 19782681 2159230 While TRAIL was capable of triggering an anti-apoptotic signaling leading to significant early *mediated* transcriptional up-regulation of [Mcl-1] in selected colon adenocarcinoma cell lines , none or very limited effects were demonstrated in cell lines derived from colon lymph node metastasis or fetal colon , respectively . Positive_regulation MCL1 EPHB2 21660051 2475880 Intracellular zinc release activated *dependent* GSK-3ß-p53 and [Noxa-Mcl-1] signaling are both involved in cardiac ischemic-reperfusion injury . Positive_regulation MCL1 EPHB2 22064351 2579546 MEK inhibition enhances ABT-737 induced leukemia cell apoptosis via prevention of activated [MCL-1] *induction* and modulation of MCL-1/BIM complex . Positive_regulation MCL1 EPHB2 23088735 2710622 Accordingly , both and p38MAPK inhibitors *attenuated* the IH-induced [Mcl-1] increase . Positive_regulation MCL1 EPHB2 9771965 539351 activation was *necessary* for the increase in [MCL1] , as inhibition of the increase in ERK phosphorylation ( with the inhibitor PD 98059 ) prevented the increase in MCL1 expression and caused rapid cell death by apoptosis . Positive_regulation MCL1 FAS 19443843 2101446 Surprisingly , siRNA knockdown of PSMB8 ( LMP7 ) , an `` immunoproteasome '' component , reversed IFNgamma induced sensitivity to Fas ligation and prevented *induced* degradation of [Mcl-1] , but did not protect p-Bcl-2 or p-Bcl-X ( L ) . Positive_regulation MCL1 MAP2K6 10961875 726545 The importance of MAPK and Akt/PKB signaling pathways in regulating the expression of Mcl-1 and cell survival was further supported by the observation that inhibition of by PD98059 or phosphatidylinositol-3 kinase (PI-3K) by LY294002 independently *resulted* in the reduction of [Mcl-1] expression and loss of cell viability . Positive_regulation MCL1 MAP2K6 11368774 817135 In contrast , [Mcl-1] mRNA levels were *dependent* upon [ mitogen activated protein kinase (MAPK)/extracellular-signal regulated protein kinase kinase ] activation , suggesting a role for the Ras/MEK/MAPK pathway in Mcl-1 transcription . Positive_regulation MCL1 MAP2K6 16083714 1442890 activation *led* to increased expression of COX-2 , Bcl-X ( L ) , [Mcl-1] , and phosphorylated Bad and decreased expression of Bak . Positive_regulation MCL1 MAP2K6 17652623 1780372 Inhibition of *resulted* in the up-regulation of the BH3-only proteins PUMA and Bim and down-regulation of the antiapoptotic protein [Mcl-1] . Positive_regulation MCL1 MAP2K6 19850869 2165370 PI3K inhibition led to down-regulation of [Mcl-1] , and inhibition *led* to up-regulation of BIM . Positive_regulation MCL1 SPHK1 17686057 1781508 IL-6 stimulation or retroviral mediated overexpression of in MM cells *resulted* in increased intracellular SPHK activity and upregulation of [myeloid cell leukaemia-1 (Mcl-1)] , leading to increased cell proliferation and survival . Positive_regulation MCL1 SPHK1 17686057 1781510 Conversely , inhibition of by small interfering RNA *reduced* IL-6 induced upregulation of [Mcl-1] and blocked the suppressive effect of IL-6 on MM cell apoptosis . Positive_regulation MCL1 TGM2 21525012 2439795 TGM2 mediated TRAIL resistance is likely through c-FLIP because suppression significantly *reduced* c-FLIP but not [Mcl-1] expression . Positive_regulation MCL1 TNF 17942758 1849463 While *had* no effect on [MCL-1] transcription , it induced expression of another antiapoptotic molecule , BFL-1 . Positive_regulation MCL1 TNF 19404960 2075177 In RA synovial fibroblasts , EGCG ( 5-50 microM ) inhibited constitutive and *induced* [Mcl-1] protein expression in a concentration- and time dependent manner ( P < 0.05 ) . Positive_regulation MCL1 TNF 20705940 2437276 We report that granulocyte/macrophage colony stimulating factor ( GM-CSF ) and *prevent* the normal time dependent loss of [Mcl-1] and Bcl2A1 in neutrophils , and we demonstrate that they cause an NF-?B dependent increase in Bcl-X ( L ) transcription/translation . Positive_regulation MCL1 TNFSF10 15385934 1324190 *induced* no discernible changes in FLIP , DR4 , DR5 , [Mcl-1] , or survivin expression , modest declines in levels of DcR2 and c-IAP , but resulted in the marked transcriptional downregulation of XIAP . Positive_regulation MCL1 TNFSF10 15637055 1380967 In sharp contrast to cycloheximide induced Mcl-1 dilapidation , did not *activate* proteasomal degradation of [Mcl-1] in Jurkat cells . Positive_regulation MCL1 TNFSF10 17613437 1768780 Reduction of *induced* [Mcl-1] and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL induced death . Positive_regulation MCL1 TNFSF10 17613437 1768784 *induced* expression of antiapoptotic [Mcl-1] and cIAP2 through activation of NF-kappaB . Positive_regulation MCL1 TNFSF10 17698840 1800598 In addition , *caused* increased binding of Bim and Puma to [Mcl-1] that was inhibited by IETD ( OMe ) -fmk but not SP600125 . Positive_regulation MCM3 DAPK1 18283219 1919282 Activation of endogenous by increasing intracellular Ca2+ also *led* to increased phosphorylation of [MCM3] . Positive_regulation MCM3 DAPK1 18283219 1919285 Importantly short hairpin RNA mediated knockdown of endogenous DAPk blocked both basal phosphorylation and Ca2+ induced phosphorylation , indicating that is both necessary and *sufficient* for [MCM3] Ser160 phosphorylation in vivo . Positive_regulation MCO TLR7 19122179 2037219 signaling via p38 *led* to phosphorylation and activation of the transcription factor [Microphthalmia] transcription factor , acting at E-box elements in the Ctsk promoter . Positive_regulation MCOLN1 NT5E 6270857 16970 The phosphatase and <5'-nucleotidase> are shown to be *activated* by [Mg2+] and Ca2+ . Positive_regulation MCOLN1 PCSK9 8306412 249048 The endonuclease activity of VP-16 treated N231 , but not , cells *required* both Ca2+ and [Mg2+] for full activity . Positive_regulation MCOLN1 RNASE1 8710510 371276 The Pac1 produces 5'-phosphate termini and *requires* [Mg2+] ; Positive_regulation MCOLN1 RNASE7 8710510 371284 The Pac1 produces 5'-phosphate termini and *requires* [Mg2+] ; Positive_regulation MCOLN1 TNF 8867673 344815 In fact , only in the presence of [Mg2+] , but not in the absence of divalent cations or in the presence of Ca2+ alone , *increased* p58c-fgr and p53/56lyn kinase activities ; Positive_regulation MCS PLAU 15944400 1416322 This is the first demonstration in vitro and in vivo that *acts* in [MCs] as a modulator of immune responses via control of immune-competent receptors . Positive_regulation MDK TNF 18275606 1872060 also *induced* [midkine] expression in PC3 cells . Positive_regulation MDM1 ITGB2 16705672 1589863 HIV-1 infected [MDM] *induced* significant increases in , glial fibrillary acidic protein , ionized calcium binding adapter molecule 1 , and proinflammatory cytokine RNA and/or protein expression when compared with HSV/HIV-1- and HIV-1 infected HFA and sham operated mice . Positive_regulation MDM1 TLR7 20084270 2194514 PMAr cells retained a high phagocytic capacity for latex beads , and expressed a cytokine profile that resembled [MDM] in *response* to ligands , in particular with marked TLR2 responses . Positive_regulation MDM2 ADRB2 17006543 1633974 [Mdm2] and GRK2 association is *enhanced* by stimulation and beta-arrestin . Positive_regulation MDM2 EPHB2 15337531 1291392 Consistent with the *mediated* control of [Mdm2] , treatment of SW480 cells with the Ras inhibitor FTS caused a marked ( 80 % ) decrease in Mdm2 , which itself would account for the increase in p53 . Positive_regulation MDM2 EPHB2 15723837 1396195 Growth and survival factor activated signaling can also *regulate* [Hdm2] expression independently of p53 , contributing to the pro-survival effect of these factors . Positive_regulation MDM2 EPHB2 17107963 1685956 *mediated* phosphorylation of [Mdm2] at Ser-166 in hepatocytes . Positive_regulation MDM2 EPHB2 17303558 1718939 Beta-arrestin and [Mdm2] *mediate* IGF-1 receptor stimulated activation and cell cycle progression . Positive_regulation MDM2 ID1 16506209 1554981 Ectopic expression *resulted* in increased serum independent cell growth and G1-S phase transition , as well as up-regulation of [mouse double minute 2 (MDM2)] and down-regulation of p21Waf1/Cip1 protein expressions in the transfectant clones in a p53 independent manner . Positive_regulation MDM2 ITGB2 16705672 1589871 HIV-1 infected [MDM] *induced* significant increases in , glial fibrillary acidic protein , ionized calcium binding adapter molecule 1 , and proinflammatory cytokine RNA and/or protein expression when compared with HSV/HIV-1- and HIV-1 infected HFA and sham operated mice . Positive_regulation MDM2 MAP2K6 15337531 1291398 Consistent with the *mediated* control of [Mdm2] , treatment of SW480 cells with the Ras inhibitor FTS caused a marked ( 80 % ) decrease in Mdm2 , which itself would account for the increase in p53 . Positive_regulation MDM2 MAP2K6 15723837 1396201 Growth and survival factor activated signaling can also *regulate* [Hdm2] expression independently of p53 , contributing to the pro-survival effect of these factors . Positive_regulation MDM2 MAP2K6 16621805 1569301 Inhibition of p38 MAPK or via pharmacological means or expression of dominant negative proteins *inhibited* the cytoplasmic accumulation of [Hdm2] and increased Hdm2 and p53 protein levels , whereas constitutively active p90Rsk promoted the nuclear export of Hdm2 . Positive_regulation MDM2 MAP2K6 17107963 1685962 *mediated* phosphorylation of [Mdm2] at Ser-166 in hepatocytes . Positive_regulation MDM2 MAP2K6 21957016 2507325 We show that , in stem-like glioblastoma cells , inhibition reduced MDM2 expression and that inhibition of either MEK or [MDM2] *resulted* in p53 activation accompanied by p53 dependent downregulation of MGMT expression . Positive_regulation MDM2 PLAU 15937335 1434020 However , *induced* [oncoprotein MDM2] in a concentration dependent manner . Positive_regulation MDM2 TLR7 20084270 2194524 PMAr cells retained a high phagocytic capacity for latex beads , and expressed a cytokine profile that resembled [MDM] in *response* to ligands , in particular with marked TLR2 responses . Positive_regulation MDM2 TNFSF10 11992615 938786 In addition , combined and wortmannin treatment *resulted* in cleavage of several proteins : PARP , Akt , p21/WAF1 , and [MDM2] as well as dephosphorylation of Akt . Positive_regulation MDM2 TP63 12374749 996672 Over expression of wild-type , but not deletion mutant , SSRP1 remarkably enhanced *dependent* luciferase activity , G1 arrest , apoptosis and expression of endogenous PIG3 , p21 ( Waf1/cip1 ) and [MDM2] in human p53-deficient lung carcinoma H1299 cells and mouse embryonic fibroblasts . Positive_regulation MDM4 ITGB2 16705672 1589873 HIV-1 infected [MDM] *induced* significant increases in , glial fibrillary acidic protein , ionized calcium binding adapter molecule 1 , and proinflammatory cytokine RNA and/or protein expression when compared with HSV/HIV-1- and HIV-1 infected HFA and sham operated mice . Positive_regulation MDM4 TLR7 20084270 2194534 PMAr cells retained a high phagocytic capacity for latex beads , and expressed a cytokine profile that resembled [MDM] in *response* to ligands , in particular with marked TLR2 responses . Positive_regulation MEA1 IL1B 19722154 2133748 In P28 , under OF and FS exposure , in the CeA remained unaltered but *increased* in the [MeA] and in the hippocampus after acute and chronic stress . Positive_regulation MEAF6 CCND1 18399550 1893749 Overexpression of [ING4] can induce growth inhibition in A549 cells both in vitro and in vivo , and also *induce* up-regulation of p27 , down-regulation of , SKP2 , and Cox2 , and inactivation of the Wnt-1/beta-catenin pathway . Positive_regulation MECP2 TNF 23123205 2717546 [MeCP2] expression was *increased* by in early differentiating cells , which was blocked by NF?B inhibitors . Positive_regulation MECP2 TNF 23123205 2717547 did not *increase* [MeCP2] expression in naïve cells . Positive_regulation MED1 ANGPT1 12890486 1117514 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED1 ANGPT1 16638932 1589750 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED1 CCND1 21928377 2539274 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED1 CD14 12435950 1016062 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED1 CD14 16574244 1582710 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED1 CHI3L1 18802121 1965049 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED1 CST6 12753433 1090307 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED1 CTGF 23108098 2721395 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED1 EDN2 7693285 231328 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED1 EDN2 8147869 252702 [TRAP] *induced* rapid morphological changes in HUVECs , with marked increase in the release of prostacyclin , , platelet activating factor , tissue type plasminogen activator , and plasminogen activator inhibitor-1 . Positive_regulation MED1 EDN2 9124581 424131 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED1 EPHB2 12769834 1107595 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED1 EPHB2 16314496 1487049 Importantly , we found that phosphorylation significantly *increases* the stability and half-life of [TRAP220/Med1] in vivo and correlates with increased thyroid hormone receptor dependent transcription . Positive_regulation MED1 EPHB2 16314496 1487050 ERK phosphorylation of ectopic TRAP220/Med1 also triggered shuttling into the nucleolus , thus suggesting that may *regulate* [TRAP220/Med1] subnuclear localization . Positive_regulation MED1 EPHB2 19755425 2158611 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Positive_regulation MED1 EPHB2 20138154 2227166 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED1 EPHB2 23684917 2796536 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED1 F2R 12370392 995988 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED1 F2R 19205424 2007276 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED1 F2R 9141614 428480 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED1 FAS 9481450 476387 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED1 ID1 11278321 798207 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED1 IL1B 11132773 760288 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED1 IL1B 20380881 2266998 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED1 IL1B 7859071 287119 The results showed that *increased* NKA-li selectively in the median eminence ( ME ) and [arcuate nucleus (ARC)] of castrated rats only . Positive_regulation MED1 IL1B 9810029 545644 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED1 ITGB2 9152024 431025 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED1 LBP 12435950 1016063 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED1 LBP 16574244 1582711 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED1 PLAT 8147869 252705 [TRAP] *induced* rapid morphological changes in HUVECs , with marked increase in the release of prostacyclin , endothelin , platelet activating factor , , and plasminogen activator inhibitor-1 . Positive_regulation MED1 TLR7 18403024 1914146 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED1 TLR7 18584038 1930845 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED1 TLR7 19631980 2132065 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED1 TLR7 21247892 2409363 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED1 TNF 11132773 760287 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED1 TNF 11159885 781446 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED1 TNF 12524657 1047976 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED1 TNF 14550746 1152752 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED1 TNF 14982858 1214554 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED1 TNF 17307735 1719113 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED1 TNF 17389616 1748470 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED1 TNF 17456789 1761152 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED1 TNF 17988550 1821532 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED1 TNF 18675993 2011536 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED1 TNF 21904602 2478335 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED1 TNF 23684917 2796535 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED1 TNF 23815148 2849310 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED1 TNF 2788206 116830 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED1 TNF 3292408 94773 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED1 TNF 7530746 291715 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED1 TNF 7947995 277239 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED1 TNF 8453746 215246 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED1 TNF 8679220 372499 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED1 TNF 9288135 452532 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED10 ANGPT1 12890486 1117506 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED10 ANGPT1 16638932 1589746 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED10 CCND1 21928377 2539237 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED10 CD14 12435950 1016052 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED10 CD14 16574244 1582698 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED10 CHI3L1 18802121 1965045 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED10 CST6 12753433 1090257 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED10 CTGF 23108098 2721390 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED10 EDN2 7693285 231316 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED10 EDN2 9124581 424119 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED10 EPHB2 12769834 1107590 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED10 EPHB2 20138154 2227150 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED10 EPHB2 23684917 2796528 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED10 F2R 12370392 995983 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED10 F2R 19205424 2007271 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED10 F2R 9141614 428475 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED10 FAS 9481450 476382 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED10 ID1 11278321 798203 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED10 IL1B 11132773 760278 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED10 IL1B 20380881 2266993 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED10 IL1B 9810029 545640 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED10 ITGB2 9152024 430953 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED10 LBP 12435950 1016053 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED10 LBP 16574244 1582699 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED10 TLR7 18403024 1914096 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED10 TLR7 18584038 1930795 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED10 TLR7 19631980 2132025 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED10 TLR7 21247892 2409313 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED10 TNF 11132773 760277 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED10 TNF 11159885 781442 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED10 TNF 12524657 1047972 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED10 TNF 14550746 1152748 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED10 TNF 14982858 1214550 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED10 TNF 17307735 1719109 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED10 TNF 17389616 1748465 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED10 TNF 17456789 1761146 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED10 TNF 17988550 1821528 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED10 TNF 18675993 2011492 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED10 TNF 21904602 2478331 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED10 TNF 23684917 2796527 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED10 TNF 23815148 2849305 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED10 TNF 2788206 116826 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED10 TNF 3292408 94769 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED10 TNF 7530746 291710 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED10 TNF 7947995 277234 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED10 TNF 8453746 215242 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED10 TNF 8679220 372495 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED10 TNF 9288135 452495 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED11 ANGPT1 12890486 1117512 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED11 ANGPT1 16638932 1589749 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED11 CCND1 21928377 2539243 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED11 CD14 12435950 1016058 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED11 CD14 16574244 1582707 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED11 CHI3L1 18802121 1965048 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED11 CST6 12753433 1090287 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED11 CTGF 23108098 2721393 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED11 EDN2 7693285 231325 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED11 EDN2 9124581 424128 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED11 EPHB2 12769834 1107593 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED11 EPHB2 20138154 2227162 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED11 EPHB2 23684917 2796534 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED11 F2R 12370392 995986 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED11 F2R 19205424 2007274 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED11 F2R 9141614 428478 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED11 FAS 9481450 476385 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED11 ID1 11278321 798206 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED11 IL1B 11132773 760284 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED11 IL1B 20380881 2266996 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED11 IL1B 9810029 545643 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED11 ITGB2 9152024 430959 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED11 LBP 12435950 1016059 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED11 LBP 16574244 1582708 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED11 TLR7 18403024 1914126 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED11 TLR7 18584038 1930825 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED11 TLR7 19631980 2132055 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED11 TLR7 21247892 2409343 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED11 TNF 11132773 760283 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED11 TNF 11159885 781445 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED11 TNF 12524657 1047975 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED11 TNF 14550746 1152751 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED11 TNF 14982858 1214553 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED11 TNF 17307735 1719112 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED11 TNF 17389616 1748468 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED11 TNF 17456789 1761149 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED11 TNF 17988550 1821531 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED11 TNF 18675993 2011501 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED11 TNF 21904602 2478334 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED11 TNF 23684917 2796533 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED11 TNF 23815148 2849308 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED11 TNF 2788206 116829 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED11 TNF 3292408 94772 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED11 TNF 7530746 291713 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED11 TNF 7947995 277237 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED11 TNF 8453746 215245 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED11 TNF 8679220 372498 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED11 TNF 9288135 452501 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED12 ANGPT1 12890486 1117456 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED12 ANGPT1 16638932 1589721 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED12 CD14 16574244 1582623 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED12 CHI3L1 18802121 1965020 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED12 EDN2 7693285 231241 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED12 EDN2 8147869 252672 [TRAP] *induced* rapid morphological changes in HUVECs , with marked increase in the release of prostacyclin , , platelet activating factor , tissue type plasminogen activator , and plasminogen activator inhibitor-1 . Positive_regulation MED12 EDN2 9124581 424044 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED12 EPHB2 19755425 2158583 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Positive_regulation MED12 EPHB2 20138154 2227050 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED12 EPHB2 23684917 2796478 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED12 ID1 11278321 798178 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED12 IL1B 7859071 287106 The results showed that *increased* NKA-li selectively in the median eminence ( ME ) and [arcuate nucleus (ARC)] of castrated rats only . Positive_regulation MED12 IL1B 9810029 545615 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED12 ITGB2 9152024 430903 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED12 LBP 16574244 1582624 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED12 PLAT 8147869 252675 [TRAP] *induced* rapid morphological changes in HUVECs , with marked increase in the release of prostacyclin , endothelin , platelet activating factor , , and plasminogen activator inhibitor-1 . Positive_regulation MED12 TLR7 19631980 2131615 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED12 TNF 11159885 781417 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED12 TNF 12524657 1047947 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED12 TNF 14550746 1152723 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED12 TNF 14982858 1214525 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED12 TNF 17307735 1719084 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED12 TNF 17988550 1821503 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED12 TNF 18675993 2011417 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED12 TNF 21904602 2478306 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED12 TNF 23684917 2796477 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED12 TNF 2788206 116801 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED12 TNF 3292408 94744 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED12 TNF 8453746 215217 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED12 TNF 8679220 372470 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED13 ANGPT1 12890486 1117476 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED13 ANGPT1 16638932 1589731 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED13 CCND1 21928377 2539211 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED13 CD14 12435950 1016026 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED13 CD14 16574244 1582653 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED13 CHI3L1 18802121 1965030 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED13 CST6 12753433 1090127 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED13 CTGF 23108098 2721377 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED13 EDN2 7693285 231271 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED13 EDN2 9124581 424074 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED13 EPHB2 12769834 1107577 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED13 EPHB2 19755425 2158593 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Positive_regulation MED13 EPHB2 20138154 2227090 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED13 EPHB2 23684917 2796498 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED13 F2R 12370392 995970 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED13 F2R 19205424 2007258 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED13 F2R 9141614 428462 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED13 FAS 9481450 476369 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED13 ID1 11278321 798188 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED13 IL1B 11132773 760252 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED13 IL1B 20380881 2266980 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED13 IL1B 7859071 287111 The results showed that *increased* NKA-li selectively in the median eminence ( ME ) and [arcuate nucleus (ARC)] of castrated rats only . Positive_regulation MED13 IL1B 9810029 545625 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED13 ITGB2 9152024 430923 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED13 LBP 12435950 1016027 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED13 LBP 16574244 1582654 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED13 TLR7 18403024 1913966 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED13 TLR7 18584038 1930665 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED13 TLR7 19631980 2131875 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED13 TLR7 21247892 2409183 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED13 TNF 11132773 760251 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED13 TNF 11159885 781427 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED13 TNF 12524657 1047957 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED13 TNF 14550746 1152733 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED13 TNF 14982858 1214535 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED13 TNF 17307735 1719094 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED13 TNF 17389616 1748452 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED13 TNF 17456789 1761133 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED13 TNF 17988550 1821513 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED13 TNF 18675993 2011447 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED13 TNF 21904602 2478316 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED13 TNF 23684917 2796497 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED13 TNF 23815148 2849292 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED13 TNF 2788206 116811 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED13 TNF 3292408 94754 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED13 TNF 7530746 291697 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED13 TNF 7947995 277221 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED13 TNF 8453746 215227 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED13 TNF 8679220 372480 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED13 TNF 9288135 452469 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED13L ANGPT1 12890486 1117478 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED13L ANGPT1 16638932 1589732 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED13L CCND1 21928377 2539213 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED13L CD14 12435950 1016028 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED13L CD14 16574244 1582656 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED13L CHI3L1 18802121 1965031 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED13L CST6 12753433 1090137 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED13L CTGF 23108098 2721378 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED13L EDN2 7693285 231274 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED13L EDN2 9124581 424077 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED13L EPHB2 12769834 1107578 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED13L EPHB2 20138154 2227094 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED13L EPHB2 23684917 2796500 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED13L F2R 12370392 995971 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED13L F2R 19205424 2007259 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED13L F2R 9141614 428463 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED13L FAS 9481450 476370 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED13L ID1 11278321 798189 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED13L IL1B 11132773 760254 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED13L IL1B 20380881 2266981 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED13L IL1B 9810029 545626 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED13L ITGB2 9152024 430925 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED13L LBP 12435950 1016029 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED13L LBP 16574244 1582657 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED13L TLR7 18403024 1913976 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED13L TLR7 18584038 1930675 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED13L TLR7 19631980 2131885 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED13L TLR7 21247892 2409193 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED13L TNF 11132773 760253 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED13L TNF 11159885 781428 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED13L TNF 12524657 1047958 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED13L TNF 14550746 1152734 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED13L TNF 14982858 1214536 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED13L TNF 17307735 1719095 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED13L TNF 17389616 1748453 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED13L TNF 17456789 1761134 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED13L TNF 17988550 1821514 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED13L TNF 18675993 2011450 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED13L TNF 21904602 2478317 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED13L TNF 23684917 2796499 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED13L TNF 23815148 2849293 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED13L TNF 2788206 116812 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED13L TNF 3292408 94755 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED13L TNF 7530746 291698 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED13L TNF 7947995 277222 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED13L TNF 8453746 215228 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED13L TNF 8679220 372481 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED13L TNF 9288135 452471 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED14 ANGPT1 12890486 1117486 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED14 ANGPT1 16638932 1589736 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED14 CCND1 21928377 2539221 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED14 CD14 12435950 1016036 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED14 CD14 16574244 1582668 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED14 CHI3L1 18802121 1965035 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED14 CST6 12753433 1090177 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED14 CTGF 23108098 2721382 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED14 EDN2 7693285 231286 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED14 EDN2 8147869 252692 [TRAP] *induced* rapid morphological changes in HUVECs , with marked increase in the release of prostacyclin , , platelet activating factor , tissue type plasminogen activator , and plasminogen activator inhibitor-1 . Positive_regulation MED14 EDN2 9124581 424089 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED14 EPHB2 12769834 1107582 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED14 EPHB2 19755425 2158597 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Positive_regulation MED14 EPHB2 20138154 2227110 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED14 EPHB2 23684917 2796508 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED14 F2R 12370392 995975 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED14 F2R 19205424 2007263 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED14 F2R 9141614 428467 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED14 FAS 9481450 476374 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED14 ID1 11278321 798193 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED14 IL1B 11132773 760262 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED14 IL1B 20380881 2266985 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED14 IL1B 7859071 287113 The results showed that *increased* NKA-li selectively in the median eminence ( ME ) and [arcuate nucleus (ARC)] of castrated rats only . Positive_regulation MED14 IL1B 9810029 545630 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED14 ITGB2 9152024 430933 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED14 LBP 12435950 1016037 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED14 LBP 16574244 1582669 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED14 PLAT 8147869 252695 [TRAP] *induced* rapid morphological changes in HUVECs , with marked increase in the release of prostacyclin , endothelin , platelet activating factor , , and plasminogen activator inhibitor-1 . Positive_regulation MED14 TLR7 18403024 1914016 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED14 TLR7 18584038 1930715 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED14 TLR7 19631980 2131925 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED14 TLR7 21247892 2409233 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED14 TNF 11132773 760261 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED14 TNF 11159885 781432 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED14 TNF 12524657 1047962 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED14 TNF 14550746 1152738 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED14 TNF 14982858 1214540 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED14 TNF 17307735 1719099 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED14 TNF 17389616 1748457 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED14 TNF 17456789 1761138 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED14 TNF 17988550 1821518 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED14 TNF 18675993 2011462 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED14 TNF 21904602 2478321 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED14 TNF 23684917 2796507 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED14 TNF 23815148 2849297 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED14 TNF 2788206 116816 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED14 TNF 3292408 94759 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED14 TNF 7530746 291702 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED14 TNF 7947995 277226 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED14 TNF 8453746 215232 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED14 TNF 8679220 372485 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED14 TNF 9288135 452479 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED15 ANGPT1 12890486 1117458 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED15 ANGPT1 16638932 1589722 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED15 CCND1 21928377 2539172 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED15 CD14 12435950 1016014 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED15 CD14 16574244 1582626 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED15 CHI3L1 18802121 1965021 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED15 CST6 12753433 1090067 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED15 CTGF 23108098 2721371 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED15 EDN2 7693285 231244 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED15 EDN2 9124581 424047 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED15 EPHB2 12769834 1107571 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED15 EPHB2 19755425 2158585 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Positive_regulation MED15 EPHB2 20138154 2227054 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED15 EPHB2 23684917 2796480 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED15 F2R 12370392 995964 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED15 F2R 19205424 2007252 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED15 F2R 9141614 428456 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED15 FAS 9481450 476363 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED15 ID1 11278321 798179 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED15 IL1B 11132773 760240 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED15 IL1B 20380881 2266974 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED15 IL1B 7859071 287107 The results showed that *increased* NKA-li selectively in the median eminence ( ME ) and [arcuate nucleus (ARC)] of castrated rats only . Positive_regulation MED15 IL1B 9810029 545616 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED15 ITGB2 9152024 430905 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED15 LBP 12435950 1016015 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED15 LBP 16574244 1582627 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED15 TLR7 18403024 1913771 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED15 TLR7 18584038 1930605 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED15 TLR7 19631980 2131625 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED15 TLR7 21247892 2409123 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED15 TNF 11132773 760239 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED15 TNF 11159885 781418 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED15 TNF 12524657 1047948 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED15 TNF 14550746 1152724 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED15 TNF 14982858 1214526 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED15 TNF 17307735 1719085 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED15 TNF 17389616 1748446 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED15 TNF 17456789 1761127 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED15 TNF 17988550 1821504 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED15 TNF 18675993 2011420 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED15 TNF 21904602 2478307 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED15 TNF 23684917 2796479 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED15 TNF 23815148 2849286 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED15 TNF 2788206 116802 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED15 TNF 3292408 94745 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED15 TNF 7530746 291691 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED15 TNF 7947995 277215 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED15 TNF 8453746 215218 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED15 TNF 8679220 372471 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED15 TNF 9288135 452457 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED16 ANGPT1 12890486 1117464 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED16 ANGPT1 16638932 1589725 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED16 CCND1 21928377 2539203 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED16 CD14 12435950 1016018 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED16 CD14 16574244 1582635 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED16 CHI3L1 18802121 1965024 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED16 CST6 12753433 1090087 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED16 CTGF 23108098 2721373 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED16 EDN2 7693285 231253 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED16 EDN2 8147869 252677 [TRAP] *induced* rapid morphological changes in HUVECs , with marked increase in the release of prostacyclin , , platelet activating factor , tissue type plasminogen activator , and plasminogen activator inhibitor-1 . Positive_regulation MED16 EDN2 9124581 424056 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED16 EPHB2 12769834 1107573 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED16 EPHB2 20138154 2227066 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED16 EPHB2 23684917 2796486 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED16 F2R 12370392 995966 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED16 F2R 19205424 2007254 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED16 F2R 9141614 428458 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED16 FAS 9481450 476365 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED16 ID1 11278321 798182 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED16 IL1B 11132773 760244 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED16 IL1B 20380881 2266976 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED16 IL1B 9810029 545619 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED16 ITGB2 9152024 430911 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED16 LBP 12435950 1016019 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED16 LBP 16574244 1582636 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED16 PLAT 8147869 252680 [TRAP] *induced* rapid morphological changes in HUVECs , with marked increase in the release of prostacyclin , endothelin , platelet activating factor , , and plasminogen activator inhibitor-1 . Positive_regulation MED16 TLR7 18403024 1913926 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED16 TLR7 18584038 1930625 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED16 TLR7 19631980 2131815 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED16 TLR7 21247892 2409143 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED16 TNF 11132773 760243 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED16 TNF 11159885 781421 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED16 TNF 12524657 1047951 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED16 TNF 14550746 1152727 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED16 TNF 14982858 1214529 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED16 TNF 17307735 1719088 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED16 TNF 17389616 1748448 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED16 TNF 17456789 1761129 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED16 TNF 17988550 1821507 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED16 TNF 18675993 2011429 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED16 TNF 21904602 2478310 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED16 TNF 23684917 2796485 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED16 TNF 23815148 2849288 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED16 TNF 2788206 116805 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED16 TNF 3292408 94748 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED16 TNF 7530746 291693 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED16 TNF 7947995 277217 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED16 TNF 8453746 215221 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED16 TNF 8679220 372474 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED16 TNF 9288135 452461 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED17 ANGPT1 12890486 1117490 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED17 ANGPT1 16638932 1589738 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED17 CCND1 21928377 2539225 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED17 CD14 12435950 1016040 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED17 CD14 16574244 1582674 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED17 CHI3L1 18802121 1965037 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED17 CST6 12753433 1090197 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED17 CTGF 23108098 2721384 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED17 EDN2 7693285 231292 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED17 EDN2 8147869 252697 [TRAP] *induced* rapid morphological changes in HUVECs , with marked increase in the release of prostacyclin , , platelet activating factor , tissue type plasminogen activator , and plasminogen activator inhibitor-1 . Positive_regulation MED17 EDN2 9124581 424095 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED17 EPHB2 12769834 1107584 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED17 EPHB2 19755425 2158601 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Positive_regulation MED17 EPHB2 20138154 2227118 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED17 EPHB2 23684917 2796512 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED17 F2R 12370392 995977 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED17 F2R 19205424 2007265 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED17 F2R 9141614 428469 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED17 FAS 9481450 476376 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED17 ID1 11278321 798195 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED17 IL1B 11132773 760266 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED17 IL1B 20380881 2266987 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED17 IL1B 7859071 287115 The results showed that *increased* NKA-li selectively in the median eminence ( ME ) and [arcuate nucleus (ARC)] of castrated rats only . Positive_regulation MED17 IL1B 9810029 545632 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED17 ITGB2 9152024 430937 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED17 LBP 12435950 1016041 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED17 LBP 16574244 1582675 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED17 PLAT 8147869 252700 [TRAP] *induced* rapid morphological changes in HUVECs , with marked increase in the release of prostacyclin , endothelin , platelet activating factor , , and plasminogen activator inhibitor-1 . Positive_regulation MED17 TLR7 18403024 1914036 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED17 TLR7 18584038 1930735 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED17 TLR7 19631980 2131945 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED17 TLR7 21247892 2409253 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED17 TNF 11132773 760265 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED17 TNF 11159885 781434 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED17 TNF 12524657 1047964 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED17 TNF 14550746 1152740 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED17 TNF 14982858 1214542 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED17 TNF 17307735 1719101 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED17 TNF 17389616 1748459 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED17 TNF 17456789 1761140 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED17 TNF 17988550 1821520 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED17 TNF 18675993 2011468 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED17 TNF 21904602 2478323 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED17 TNF 23684917 2796511 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED17 TNF 23815148 2849299 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED17 TNF 2788206 116818 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED17 TNF 3292408 94761 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED17 TNF 7530746 291704 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED17 TNF 7947995 277228 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED17 TNF 8453746 215234 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED17 TNF 8679220 372487 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED17 TNF 9288135 452483 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED18 ANGPT1 12890486 1117504 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED18 ANGPT1 16638932 1589745 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED18 CCND1 21928377 2539235 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED18 CD14 12435950 1016050 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED18 CD14 16574244 1582695 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED18 CHI3L1 18802121 1965044 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED18 CST6 12753433 1090247 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED18 CTGF 23108098 2721389 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED18 EDN2 7693285 231313 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED18 EDN2 9124581 424116 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED18 EPHB2 12769834 1107589 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED18 EPHB2 20138154 2227146 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED18 EPHB2 23684917 2796526 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED18 F2R 12370392 995982 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED18 F2R 19205424 2007270 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED18 F2R 9141614 428474 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED18 FAS 9481450 476381 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED18 ID1 11278321 798202 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED18 IL1B 11132773 760276 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED18 IL1B 20380881 2266992 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED18 IL1B 9810029 545639 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED18 ITGB2 9152024 430951 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED18 LBP 12435950 1016051 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED18 LBP 16574244 1582696 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED18 TLR7 18403024 1914086 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED18 TLR7 18584038 1930785 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED18 TLR7 19631980 2132015 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED18 TLR7 21247892 2409303 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED18 TNF 11132773 760275 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED18 TNF 11159885 781441 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED18 TNF 12524657 1047971 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED18 TNF 14550746 1152747 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED18 TNF 14982858 1214549 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED18 TNF 17307735 1719108 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED18 TNF 17389616 1748464 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED18 TNF 17456789 1761145 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED18 TNF 17988550 1821527 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED18 TNF 18675993 2011489 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED18 TNF 21904602 2478330 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED18 TNF 23684917 2796525 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED18 TNF 23815148 2849304 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED18 TNF 2788206 116825 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED18 TNF 3292408 94768 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED18 TNF 7530746 291709 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED18 TNF 7947995 277233 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED18 TNF 8453746 215241 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED18 TNF 8679220 372494 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED18 TNF 9288135 452493 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED19 ANGPT1 12890486 1117510 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED19 ANGPT1 16638932 1589748 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED19 CCND1 21928377 2539241 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED19 CD14 12435950 1016056 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED19 CD14 16574244 1582704 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED19 CHI3L1 18802121 1965047 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED19 CST6 12753433 1090277 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED19 CTGF 23108098 2721392 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED19 EDN2 7693285 231322 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED19 EDN2 9124581 424125 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED19 EPHB2 12769834 1107592 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED19 EPHB2 20138154 2227158 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED19 EPHB2 23684917 2796532 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED19 F2R 12370392 995985 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED19 F2R 19205424 2007273 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED19 F2R 9141614 428477 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED19 FAS 9481450 476384 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED19 ID1 11278321 798205 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED19 IL1B 11132773 760282 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED19 IL1B 20380881 2266995 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED19 IL1B 9810029 545642 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED19 ITGB2 9152024 430957 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED19 LBP 12435950 1016057 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED19 LBP 16574244 1582705 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED19 TLR7 18403024 1914116 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED19 TLR7 18584038 1930815 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED19 TLR7 19631980 2132045 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED19 TLR7 21247892 2409333 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED19 TNF 11132773 760281 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED19 TNF 11159885 781444 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED19 TNF 12524657 1047974 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED19 TNF 14550746 1152750 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED19 TNF 14982858 1214552 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED19 TNF 17307735 1719111 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED19 TNF 17389616 1748467 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED19 TNF 17456789 1761148 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED19 TNF 17988550 1821530 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED19 TNF 18675993 2011498 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED19 TNF 21904602 2478333 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED19 TNF 23684917 2796531 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED19 TNF 23815148 2849307 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED19 TNF 2788206 116828 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED19 TNF 3292408 94771 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED19 TNF 7530746 291712 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED19 TNF 7947995 277236 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED19 TNF 8453746 215244 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED19 TNF 8679220 372497 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED19 TNF 9288135 452499 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED20 ANGPT1 12890486 1117462 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED20 ANGPT1 16638932 1589724 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED20 CCND1 21928377 2539201 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED20 CD14 12435950 1016016 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED20 CD14 16574244 1582632 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED20 CHI3L1 18802121 1965023 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED20 CST6 12753433 1090077 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED20 CTGF 23108098 2721372 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED20 EDN2 7693285 231250 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED20 EDN2 9124581 424053 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED20 EPHB2 12769834 1107572 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED20 EPHB2 20138154 2227062 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED20 EPHB2 23684917 2796484 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED20 F2R 12370392 995965 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED20 F2R 19205424 2007253 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED20 F2R 9141614 428457 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED20 FAS 9481450 476364 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED20 ID1 11278321 798181 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED20 IL1B 11132773 760242 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED20 IL1B 20380881 2266975 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED20 IL1B 9810029 545618 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED20 ITGB2 9152024 430909 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED20 LBP 12435950 1016017 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED20 LBP 16574244 1582633 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED20 TLR7 18403024 1913916 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED20 TLR7 18584038 1930615 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED20 TLR7 19631980 2131805 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED20 TLR7 21247892 2409133 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED20 TNF 11132773 760241 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED20 TNF 11159885 781420 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED20 TNF 12524657 1047950 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED20 TNF 14550746 1152726 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED20 TNF 14982858 1214528 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED20 TNF 17307735 1719087 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED20 TNF 17389616 1748447 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED20 TNF 17456789 1761128 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED20 TNF 17988550 1821506 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED20 TNF 18675993 2011426 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED20 TNF 21904602 2478309 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED20 TNF 23684917 2796483 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED20 TNF 23815148 2849287 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED20 TNF 2788206 116804 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED20 TNF 3292408 94747 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED20 TNF 7530746 291692 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED20 TNF 7947995 277216 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED20 TNF 8453746 215220 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED20 TNF 8679220 372473 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED20 TNF 9288135 452459 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED21 ANGPT1 12890486 1117452 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED21 ANGPT1 16638932 1589719 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED21 CCND1 21928377 2539168 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED21 CD14 12435950 1016010 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED21 CD14 16574244 1582617 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED21 CHI3L1 18802121 1965018 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED21 CST6 12753433 1090047 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED21 CTGF 23108098 2721369 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED21 EDN2 7693285 231235 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED21 EDN2 9124581 424038 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED21 EPHB2 12769834 1107569 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED21 EPHB2 20138154 2227042 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED21 EPHB2 23684917 2796474 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED21 F2R 12370392 995962 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED21 F2R 19205424 2007250 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED21 F2R 9141614 428454 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED21 FAS 9481450 476361 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED21 ID1 11278321 798176 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED21 IL1B 11132773 760236 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED21 IL1B 20380881 2266972 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED21 IL1B 7859071 287105 The results showed that *increased* NKA-li selectively in the median eminence ( ME ) and [arcuate nucleus (ARC)] of castrated rats only . Positive_regulation MED21 IL1B 9810029 545613 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED21 ITGB2 9152024 430899 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED21 LBP 12435950 1016011 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED21 LBP 16574244 1582618 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED21 TLR7 18403024 1913616 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED21 TLR7 18584038 1930585 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED21 TLR7 19631980 2131435 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED21 TLR7 21247892 2409103 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED21 TNF 11132773 760235 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED21 TNF 11159885 781415 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED21 TNF 12524657 1047945 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED21 TNF 14550746 1152721 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED21 TNF 14622953 1169198 p300 and its associated factor PCAF levels but not [Srb7] , Med7 , or TFII ( B ) were *increased* by phorbol ester or alpha stimulation . Positive_regulation MED21 TNF 14982858 1214491 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED21 TNF 17307735 1719082 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED21 TNF 17389616 1748444 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED21 TNF 17456789 1761097 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED21 TNF 17988550 1821501 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED21 TNF 18675993 2011379 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED21 TNF 21904602 2478304 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED21 TNF 23684917 2796473 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED21 TNF 23815148 2849284 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED21 TNF 2788206 116799 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED21 TNF 3292408 94710 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED21 TNF 7530746 291689 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED21 TNF 7947995 277213 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED21 TNF 8453746 215215 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED21 TNF 8679220 372468 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED21 TNF 9288135 452426 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED22 ANGPT1 12890486 1117454 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED22 ANGPT1 16638932 1589720 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED22 CCND1 21928377 2539170 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED22 CD14 12435950 1016012 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED22 CD14 16574244 1582620 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED22 CHI3L1 18802121 1965019 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED22 CST6 12753433 1090057 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED22 CTGF 23108098 2721370 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED22 EDN2 7693285 231238 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED22 EDN2 9124581 424041 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED22 EPHB2 12769834 1107570 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED22 EPHB2 20138154 2227046 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED22 EPHB2 23684917 2796476 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED22 F2R 12370392 995963 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED22 F2R 19205424 2007251 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED22 F2R 9141614 428455 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED22 FAS 9481450 476362 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED22 ID1 11278321 798177 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED22 IL1B 11132773 760238 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED22 IL1B 20380881 2266973 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED22 IL1B 9810029 545614 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED22 ITGB2 9152024 430901 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED22 LBP 12435950 1016013 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED22 LBP 16574244 1582621 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED22 TLR7 18403024 1913626 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED22 TLR7 18584038 1930595 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED22 TLR7 19631980 2131445 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED22 TLR7 21247892 2409113 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED22 TNF 11132773 760237 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED22 TNF 11159885 781416 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED22 TNF 12524657 1047946 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED22 TNF 14550746 1152722 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED22 TNF 14982858 1214492 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED22 TNF 17307735 1719083 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED22 TNF 17389616 1748445 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED22 TNF 17456789 1761098 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED22 TNF 17988550 1821502 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED22 TNF 18675993 2011382 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED22 TNF 21904602 2478305 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED22 TNF 23684917 2796475 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED22 TNF 23815148 2849285 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED22 TNF 2788206 116800 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED22 TNF 3292408 94711 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED22 TNF 7530746 291690 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED22 TNF 7947995 277214 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED22 TNF 8453746 215216 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED22 TNF 8679220 372469 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED22 TNF 9288135 452428 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED23 ANGPT1 12890486 1117488 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED23 ANGPT1 16638932 1589737 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED23 CCND1 21928377 2539223 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED23 CD14 12435950 1016038 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED23 CD14 16574244 1582671 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED23 CHI3L1 18802121 1965036 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED23 CST6 12753433 1090187 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED23 CTGF 23108098 2721383 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED23 EDN2 7693285 231289 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED23 EDN2 9124581 424092 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED23 EPHB2 12769834 1107583 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED23 EPHB2 19755425 2158599 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Positive_regulation MED23 EPHB2 20138154 2227114 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED23 EPHB2 23684917 2796510 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED23 F2R 12370392 995976 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED23 F2R 19205424 2007264 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED23 F2R 9141614 428468 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED23 FAS 9481450 476375 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED23 ID1 11278321 798194 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED23 IL1B 11132773 760264 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED23 IL1B 20380881 2266986 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED23 IL1B 7859071 287114 The results showed that *increased* NKA-li selectively in the median eminence ( ME ) and [arcuate nucleus (ARC)] of castrated rats only . Positive_regulation MED23 IL1B 9810029 545631 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED23 ITGB2 9152024 430935 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED23 LBP 12435950 1016039 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED23 LBP 16574244 1582672 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED23 TLR7 18403024 1914026 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED23 TLR7 18584038 1930725 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED23 TLR7 19631980 2131935 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED23 TLR7 21247892 2409243 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED23 TNF 11132773 760263 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED23 TNF 11159885 781433 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED23 TNF 12524657 1047963 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED23 TNF 14550746 1152739 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED23 TNF 14982858 1214541 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED23 TNF 17307735 1719100 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED23 TNF 17389616 1748458 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED23 TNF 17456789 1761139 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED23 TNF 17988550 1821519 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED23 TNF 18675993 2011465 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED23 TNF 21904602 2478322 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED23 TNF 23684917 2796509 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED23 TNF 23815148 2849298 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED23 TNF 2788206 116817 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED23 TNF 3292408 94760 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED23 TNF 7530746 291703 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED23 TNF 7947995 277227 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED23 TNF 8453746 215233 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED23 TNF 8679220 372486 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED23 TNF 9288135 452481 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED24 ANGPT1 12890486 1117480 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED24 ANGPT1 16638932 1589733 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED24 CCND1 21928377 2539215 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED24 CD14 12435950 1016030 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED24 CD14 16574244 1582659 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED24 CHI3L1 18802121 1965032 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED24 CST6 12753433 1090147 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED24 CTGF 23108098 2721379 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED24 EDN2 7693285 231277 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED24 EDN2 8147869 252682 [TRAP] *induced* rapid morphological changes in HUVECs , with marked increase in the release of prostacyclin , , platelet activating factor , tissue type plasminogen activator , and plasminogen activator inhibitor-1 . Positive_regulation MED24 EDN2 9124581 424080 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED24 EPHB2 12769834 1107579 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED24 EPHB2 19755425 2158595 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Positive_regulation MED24 EPHB2 20138154 2227098 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED24 EPHB2 23684917 2796502 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED24 F2R 12370392 995972 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED24 F2R 19205424 2007260 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED24 F2R 9141614 428464 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED24 FAS 9481450 476371 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED24 ID1 11278321 798190 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED24 IL1B 11132773 760256 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED24 IL1B 20380881 2266982 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED24 IL1B 7859071 287112 The results showed that *increased* NKA-li selectively in the median eminence ( ME ) and [arcuate nucleus (ARC)] of castrated rats only . Positive_regulation MED24 IL1B 9810029 545627 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED24 ITGB2 9152024 430927 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED24 LBP 12435950 1016031 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED24 LBP 16574244 1582660 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED24 PLAT 8147869 252685 [TRAP] *induced* rapid morphological changes in HUVECs , with marked increase in the release of prostacyclin , endothelin , platelet activating factor , , and plasminogen activator inhibitor-1 . Positive_regulation MED24 TLR7 18403024 1913986 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED24 TLR7 18584038 1930685 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED24 TLR7 19631980 2131895 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED24 TLR7 21247892 2409203 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED24 TNF 11132773 760255 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED24 TNF 11159885 781429 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED24 TNF 12524657 1047959 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED24 TNF 14550746 1152735 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED24 TNF 14982858 1214537 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED24 TNF 17307735 1719096 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED24 TNF 17389616 1748454 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED24 TNF 17456789 1761135 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED24 TNF 17988550 1821515 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED24 TNF 18675993 2011453 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED24 TNF 21904602 2478318 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED24 TNF 23684917 2796501 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED24 TNF 23815148 2849294 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED24 TNF 2788206 116813 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED24 TNF 3292408 94756 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED24 TNF 7530746 291699 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED24 TNF 7947995 277223 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED24 TNF 8453746 215229 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED24 TNF 8679220 372482 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED24 TNF 9288135 452473 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED25 ANGPT1 12890486 1117508 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED25 ANGPT1 16638932 1589747 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED25 CCND1 21928377 2539239 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED25 CD14 12435950 1016054 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED25 CD14 16574244 1582701 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED25 CHI3L1 18802121 1965046 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED25 CST6 12753433 1090267 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED25 CTGF 23108098 2721391 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED25 EDN2 7693285 231319 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED25 EDN2 9124581 424122 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED25 EPHB2 12769834 1107591 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED25 EPHB2 19755425 2158607 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Positive_regulation MED25 EPHB2 20138154 2227154 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED25 EPHB2 23684917 2796530 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED25 F2R 12370392 995984 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED25 F2R 19205424 2007272 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED25 F2R 9141614 428476 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED25 FAS 9481450 476383 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED25 ID1 11278321 798204 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED25 IL1B 11132773 760280 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED25 IL1B 20380881 2266994 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED25 IL1B 7859071 287118 The results showed that *increased* NKA-li selectively in the median eminence ( ME ) and [arcuate nucleus (ARC)] of castrated rats only . Positive_regulation MED25 IL1B 9810029 545641 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED25 ITGB2 9152024 430955 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED25 LBP 12435950 1016055 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED25 LBP 16574244 1582702 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED25 TLR7 18403024 1914106 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED25 TLR7 18584038 1930805 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED25 TLR7 19631980 2132035 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED25 TLR7 21247892 2409323 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED25 TNF 11132773 760279 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED25 TNF 11159885 781443 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED25 TNF 12524657 1047973 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED25 TNF 14550746 1152749 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED25 TNF 14982858 1214551 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED25 TNF 17307735 1719110 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED25 TNF 17389616 1748466 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED25 TNF 17456789 1761147 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED25 TNF 17988550 1821529 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED25 TNF 18675993 2011495 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED25 TNF 21904602 2478332 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED25 TNF 23684917 2796529 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED25 TNF 23815148 2849306 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED25 TNF 2788206 116827 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED25 TNF 3292408 94770 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED25 TNF 7530746 291711 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED25 TNF 7947995 277235 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED25 TNF 8453746 215243 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED25 TNF 8679220 372496 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED25 TNF 9288135 452497 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED26 ANGPT1 12890486 1117492 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED26 ANGPT1 16638932 1589739 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED26 CCND1 21928377 2539227 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED26 CD14 12435950 1016042 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED26 CD14 16574244 1582677 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED26 CHI3L1 18802121 1965038 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED26 CST6 12753433 1090207 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED26 CTGF 23108098 2721385 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED26 EDN2 7693285 231295 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED26 EDN2 9124581 424098 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED26 EPHB2 12769834 1107585 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED26 EPHB2 19755425 2158603 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Positive_regulation MED26 EPHB2 20138154 2227122 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED26 EPHB2 23684917 2796514 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED26 F2R 12370392 995978 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED26 F2R 19205424 2007266 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED26 F2R 9141614 428470 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED26 FAS 9481450 476377 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED26 ID1 11278321 798196 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED26 IL1B 11132773 760268 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED26 IL1B 20380881 2266988 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED26 IL1B 7859071 287116 The results showed that *increased* NKA-li selectively in the median eminence ( ME ) and [arcuate nucleus (ARC)] of castrated rats only . Positive_regulation MED26 IL1B 9810029 545633 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED26 ITGB2 9152024 430939 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED26 LBP 12435950 1016043 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED26 LBP 16574244 1582678 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED26 TLR7 18403024 1914046 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED26 TLR7 18584038 1930745 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED26 TLR7 19631980 2131955 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED26 TLR7 21247892 2409263 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED26 TNF 11132773 760267 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED26 TNF 11159885 781435 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED26 TNF 12524657 1047965 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED26 TNF 14550746 1152741 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED26 TNF 14982858 1214543 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED26 TNF 17307735 1719102 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED26 TNF 17389616 1748460 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED26 TNF 17456789 1761141 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED26 TNF 17988550 1821521 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED26 TNF 18675993 2011471 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED26 TNF 21904602 2478324 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED26 TNF 23684917 2796513 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED26 TNF 23815148 2849300 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED26 TNF 2788206 116819 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED26 TNF 3292408 94762 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED26 TNF 7530746 291705 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED26 TNF 7947995 277229 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED26 TNF 8453746 215235 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED26 TNF 8679220 372488 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED26 TNF 9288135 452485 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED27 ANGPT1 12890486 1117494 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED27 ANGPT1 16638932 1589740 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED27 CCND1 21928377 2539229 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED27 CD14 12435950 1016044 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED27 CD14 16574244 1582680 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED27 CHI3L1 18802121 1965039 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED27 CST6 12753433 1090217 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED27 CTGF 23108098 2721386 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED27 EDN2 7693285 231298 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED27 EDN2 9124581 424101 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED27 EPHB2 12769834 1107586 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED27 EPHB2 20138154 2227126 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED27 EPHB2 23684917 2796516 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED27 F2R 12370392 995979 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED27 F2R 19205424 2007267 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED27 F2R 9141614 428471 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED27 FAS 9481450 476378 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED27 ID1 11278321 798197 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED27 IL1B 11132773 760270 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED27 IL1B 20380881 2266989 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED27 IL1B 9810029 545634 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED27 ITGB2 9152024 430941 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED27 LBP 12435950 1016045 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED27 LBP 16574244 1582681 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED27 TLR7 18403024 1914056 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED27 TLR7 18584038 1930755 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED27 TLR7 19631980 2131965 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED27 TLR7 21247892 2409273 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED27 TNF 11132773 760269 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED27 TNF 11159885 781436 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED27 TNF 12524657 1047966 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED27 TNF 14550746 1152742 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED27 TNF 14982858 1214544 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED27 TNF 17307735 1719103 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED27 TNF 17389616 1748461 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED27 TNF 17456789 1761142 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED27 TNF 17988550 1821522 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED27 TNF 18675993 2011474 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED27 TNF 21904602 2478325 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED27 TNF 23684917 2796515 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED27 TNF 23815148 2849301 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED27 TNF 2788206 116820 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED27 TNF 3292408 94763 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED27 TNF 7530746 291706 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED27 TNF 7947995 277230 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED27 TNF 8453746 215236 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED27 TNF 8679220 372489 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED27 TNF 9288135 452487 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED28 ANGPT1 12890486 1117500 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED28 ANGPT1 16638932 1589743 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED28 CD14 16574244 1582689 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED28 CHI3L1 18802121 1965042 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED28 EDN2 7693285 231307 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED28 EDN2 9124581 424110 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED28 EPHB2 20138154 2227138 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED28 EPHB2 23684917 2796522 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED28 ID1 11278321 798200 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED28 IL1B 9810029 545637 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED28 ITGB2 9152024 430947 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED28 LBP 16574244 1582690 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED28 TLR7 19631980 2131995 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED28 TNF 11159885 781439 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED28 TNF 12524657 1047969 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED28 TNF 14550746 1152745 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED28 TNF 14982858 1214547 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED28 TNF 17307735 1719106 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED28 TNF 17988550 1821525 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED28 TNF 18675993 2011483 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED28 TNF 21904602 2478328 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED28 TNF 23684917 2796521 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED28 TNF 2788206 116823 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED28 TNF 3292408 94766 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED28 TNF 8453746 215239 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED28 TNF 8679220 372492 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED29 ANGPT1 12890486 1117484 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED29 ANGPT1 16638932 1589735 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED29 CCND1 21928377 2539219 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED29 CD14 12435950 1016034 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED29 CD14 16574244 1582665 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED29 CHI3L1 18802121 1965034 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED29 CST6 12753433 1090167 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED29 CTGF 23108098 2721381 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED29 EDN2 7693285 231283 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED29 EDN2 9124581 424086 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED29 EPHB2 12769834 1107581 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED29 EPHB2 20138154 2227106 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED29 EPHB2 23684917 2796506 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED29 F2R 12370392 995974 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED29 F2R 19205424 2007262 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED29 F2R 9141614 428466 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED29 FAS 9481450 476373 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED29 ID1 11278321 798192 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED29 IL1B 11132773 760260 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED29 IL1B 20380881 2266984 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED29 IL1B 9810029 545629 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED29 ITGB2 9152024 430931 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED29 LBP 12435950 1016035 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED29 LBP 16574244 1582666 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED29 TLR7 18403024 1914006 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED29 TLR7 18584038 1930705 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED29 TLR7 19631980 2131915 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED29 TLR7 21247892 2409223 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED29 TNF 11132773 760259 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED29 TNF 11159885 781431 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED29 TNF 12524657 1047961 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED29 TNF 14550746 1152737 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED29 TNF 14982858 1214539 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED29 TNF 17307735 1719098 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED29 TNF 17389616 1748456 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED29 TNF 17456789 1761137 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED29 TNF 17988550 1821517 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED29 TNF 18675993 2011459 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED29 TNF 21904602 2478320 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED29 TNF 23684917 2796505 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED29 TNF 23815148 2849296 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED29 TNF 2788206 116815 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED29 TNF 3292408 94758 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED29 TNF 7530746 291701 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED29 TNF 7947995 277225 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED29 TNF 8453746 215231 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED29 TNF 8679220 372484 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED29 TNF 9288135 452477 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED30 ANGPT1 12890486 1117482 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED30 ANGPT1 16638932 1589734 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED30 CCND1 21928377 2539217 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED30 CD14 12435950 1016032 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED30 CD14 16574244 1582662 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED30 CHI3L1 18802121 1965033 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED30 CST6 12753433 1090157 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED30 CTGF 23108098 2721380 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED30 EDN2 7693285 231280 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED30 EDN2 9124581 424083 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED30 EPHB2 12769834 1107580 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED30 EPHB2 20138154 2227102 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED30 EPHB2 23684917 2796504 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED30 F2R 12370392 995973 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED30 F2R 19205424 2007261 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED30 F2R 9141614 428465 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED30 FAS 9481450 476372 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED30 ID1 11278321 798191 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED30 IL1B 11132773 760258 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED30 IL1B 20380881 2266983 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED30 IL1B 9810029 545628 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED30 ITGB2 9152024 430929 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED30 LBP 12435950 1016033 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED30 LBP 16574244 1582663 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED30 TLR7 18403024 1913996 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED30 TLR7 18584038 1930695 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED30 TLR7 19631980 2131905 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED30 TLR7 21247892 2409213 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED30 TNF 11132773 760257 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED30 TNF 11159885 781430 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED30 TNF 12524657 1047960 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED30 TNF 14550746 1152736 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED30 TNF 14982858 1214538 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED30 TNF 17307735 1719097 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED30 TNF 17389616 1748455 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED30 TNF 17456789 1761136 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED30 TNF 17988550 1821516 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED30 TNF 18675993 2011456 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED30 TNF 21904602 2478319 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED30 TNF 23684917 2796503 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED30 TNF 23815148 2849295 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED30 TNF 2788206 116814 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED30 TNF 3292408 94757 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED30 TNF 7530746 291700 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED30 TNF 7947995 277224 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED30 TNF 8453746 215230 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED30 TNF 8679220 372483 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED30 TNF 9288135 452475 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED31 ANGPT1 12890486 1117498 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED31 ANGPT1 16638932 1589742 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED31 CCND1 21928377 2539233 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED31 CD14 12435950 1016048 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED31 CD14 16574244 1582686 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED31 CHI3L1 18802121 1965041 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED31 CST6 12753433 1090237 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED31 CTGF 23108098 2721388 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED31 EDN2 7693285 231304 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED31 EDN2 9124581 424107 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED31 EPHB2 12769834 1107588 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED31 EPHB2 20138154 2227134 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED31 EPHB2 23684917 2796520 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED31 F2R 12370392 995981 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED31 F2R 19205424 2007269 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED31 F2R 9141614 428473 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED31 FAS 9481450 476380 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED31 ID1 11278321 798199 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED31 IL1B 11132773 760274 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED31 IL1B 20380881 2266991 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED31 IL1B 9810029 545636 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED31 ITGB2 9152024 430945 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED31 LBP 12435950 1016049 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED31 LBP 16574244 1582687 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED31 TLR7 18403024 1914076 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED31 TLR7 18584038 1930775 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED31 TLR7 19631980 2131985 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED31 TLR7 21247892 2409293 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED31 TNF 11132773 760273 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED31 TNF 11159885 781438 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED31 TNF 12524657 1047968 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED31 TNF 14550746 1152744 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED31 TNF 14982858 1214546 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED31 TNF 17307735 1719105 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED31 TNF 17389616 1748463 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED31 TNF 17456789 1761144 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED31 TNF 17988550 1821524 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED31 TNF 18675993 2011480 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED31 TNF 21904602 2478327 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED31 TNF 23684917 2796519 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED31 TNF 23815148 2849303 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED31 TNF 2788206 116822 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED31 TNF 3292408 94765 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED31 TNF 7530746 291708 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED31 TNF 7947995 277232 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED31 TNF 8453746 215238 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED31 TNF 8679220 372491 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED31 TNF 9288135 452491 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED4 ANGPT1 12890486 1117468 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED4 ANGPT1 16638932 1589727 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED4 CCND1 21928377 2539205 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED4 CD14 12435950 1016020 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED4 CD14 16574244 1582641 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED4 CHI3L1 18802121 1965026 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED4 CST6 12753433 1090097 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED4 CTGF 23108098 2721374 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED4 EDN2 7693285 231259 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED4 EDN2 9124581 424062 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED4 EPHB2 12769834 1107574 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED4 EPHB2 19755425 2158587 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Positive_regulation MED4 EPHB2 20138154 2227074 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED4 EPHB2 23684917 2796490 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED4 F2R 12370392 995967 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED4 F2R 19205424 2007255 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED4 F2R 9141614 428459 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED4 FAS 9481450 476366 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED4 ID1 11278321 798184 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED4 IL1B 11132773 760246 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED4 IL1B 20380881 2266977 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED4 IL1B 9810029 545621 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED4 ITGB2 9152024 430915 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED4 LBP 12435950 1016021 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED4 LBP 16574244 1582642 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED4 TLR7 18403024 1913936 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED4 TLR7 18584038 1930635 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED4 TLR7 19631980 2131835 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED4 TLR7 21247892 2409153 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED4 TNF 11132773 760245 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED4 TNF 11159885 781423 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED4 TNF 12524657 1047953 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED4 TNF 14550746 1152729 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED4 TNF 14982858 1214531 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED4 TNF 17307735 1719090 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED4 TNF 17389616 1748449 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED4 TNF 17456789 1761130 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED4 TNF 17988550 1821509 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED4 TNF 18675993 2011435 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED4 TNF 21904602 2478312 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED4 TNF 23684917 2796489 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED4 TNF 23815148 2849289 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED4 TNF 2788206 116807 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED4 TNF 3292408 94750 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED4 TNF 7530746 291694 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED4 TNF 7947995 277218 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED4 TNF 8453746 215223 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED4 TNF 8679220 372476 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED4 TNF 9288135 452463 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED6 ANGPT1 12890486 1117472 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED6 ANGPT1 16638932 1589729 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED6 CCND1 21928377 2539207 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED6 CD14 12435950 1016022 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED6 CD14 16574244 1582647 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED6 CHI3L1 18802121 1965028 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED6 CST6 12753433 1090107 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED6 CTGF 23108098 2721375 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED6 EDN2 7693285 231265 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED6 EDN2 9124581 424068 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED6 EPHB2 12769834 1107575 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED6 EPHB2 19755425 2158589 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Positive_regulation MED6 EPHB2 20138154 2227082 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED6 EPHB2 23684917 2796494 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED6 F2R 12370392 995968 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED6 F2R 19205424 2007256 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED6 F2R 9141614 428460 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED6 FAS 9481450 476367 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED6 ID1 11278321 798186 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED6 IL1B 11132773 760248 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED6 IL1B 20380881 2266978 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED6 IL1B 7859071 287110 The results showed that *increased* NKA-li selectively in the median eminence ( ME ) and [arcuate nucleus (ARC)] of castrated rats only . Positive_regulation MED6 IL1B 9810029 545623 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED6 ITGB2 9152024 430919 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED6 LBP 12435950 1016023 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED6 LBP 16574244 1582648 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED6 TLR7 18403024 1913946 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED6 TLR7 18584038 1930645 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED6 TLR7 19631980 2131855 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED6 TLR7 21247892 2409163 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED6 TNF 11132773 760247 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED6 TNF 11159885 781425 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED6 TNF 12524657 1047955 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED6 TNF 14550746 1152731 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED6 TNF 14982858 1214533 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED6 TNF 17307735 1719092 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED6 TNF 17389616 1748450 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED6 TNF 17456789 1761131 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED6 TNF 17988550 1821511 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED6 TNF 18675993 2011441 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED6 TNF 21904602 2478314 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED6 TNF 23684917 2796493 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED6 TNF 23815148 2849290 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED6 TNF 2788206 116809 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED6 TNF 3292408 94752 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED6 TNF 7530746 291695 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED6 TNF 7947995 277219 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED6 TNF 8453746 215225 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED6 TNF 8679220 372478 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED6 TNF 9288135 452465 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED7 ANGPT1 12890486 1117496 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED7 ANGPT1 16638932 1589741 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED7 CCND1 21928377 2539231 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED7 CD14 12435950 1016046 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED7 CD14 16574244 1582683 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED7 CHI3L1 18802121 1965040 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED7 CST6 12753433 1090227 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED7 CTGF 23108098 2721387 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED7 EDN2 7693285 231301 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED7 EDN2 9124581 424104 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED7 EPHB2 12769834 1107587 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED7 EPHB2 19755425 2158605 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Positive_regulation MED7 EPHB2 20138154 2227130 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED7 EPHB2 23684917 2796518 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED7 F2R 12370392 995980 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED7 F2R 19205424 2007268 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED7 F2R 9141614 428472 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED7 FAS 9481450 476379 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED7 ID1 11278321 798198 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED7 IL1B 11132773 760272 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED7 IL1B 20380881 2266990 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED7 IL1B 7859071 287117 The results showed that *increased* NKA-li selectively in the median eminence ( ME ) and [arcuate nucleus (ARC)] of castrated rats only . Positive_regulation MED7 IL1B 9810029 545635 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED7 ITGB2 9152024 430943 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED7 LBP 12435950 1016047 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED7 LBP 16574244 1582684 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED7 TLR7 18403024 1914066 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED7 TLR7 18584038 1930765 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED7 TLR7 19631980 2131975 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED7 TLR7 21247892 2409283 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED7 TNF 11132773 760271 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED7 TNF 11159885 781437 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED7 TNF 12524657 1047967 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED7 TNF 14550746 1152743 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED7 TNF 14622953 1169199 p300 and its associated factor PCAF levels but not Srb7 , [Med7] , or TFII ( B ) were *increased* by phorbol ester or alpha stimulation . Positive_regulation MED7 TNF 14982858 1214545 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED7 TNF 17307735 1719104 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED7 TNF 17389616 1748462 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED7 TNF 17456789 1761143 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED7 TNF 17988550 1821523 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED7 TNF 18675993 2011477 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED7 TNF 21904602 2478326 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED7 TNF 23684917 2796517 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED7 TNF 23815148 2849302 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED7 TNF 2788206 116821 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED7 TNF 3292408 94764 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED7 TNF 7530746 291707 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED7 TNF 7947995 277231 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED7 TNF 8453746 215237 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED7 TNF 8679220 372490 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED7 TNF 9288135 452489 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED8 ANGPT1 12890486 1117474 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED8 ANGPT1 16638932 1589730 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED8 CCND1 21928377 2539209 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation MED8 CD14 12435950 1016024 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED8 CD14 16574244 1582650 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED8 CHI3L1 18802121 1965029 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED8 CST6 12753433 1090117 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation MED8 CTGF 23108098 2721376 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation MED8 EDN2 7693285 231268 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED8 EDN2 9124581 424071 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED8 EPHB2 12769834 1107576 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation MED8 EPHB2 19755425 2158591 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Positive_regulation MED8 EPHB2 20138154 2227086 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED8 EPHB2 23684917 2796496 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED8 F2R 12370392 995969 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation MED8 F2R 19205424 2007257 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation MED8 F2R 9141614 428461 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation MED8 FAS 9481450 476368 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation MED8 ID1 11278321 798187 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED8 IL1B 11132773 760250 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED8 IL1B 20380881 2266979 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation MED8 IL1B 9810029 545624 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED8 ITGB2 9152024 430921 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED8 LBP 12435950 1016025 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation MED8 LBP 16574244 1582651 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED8 TLR7 18403024 1913956 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation MED8 TLR7 18584038 1930655 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation MED8 TLR7 19631980 2131865 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED8 TLR7 21247892 2409173 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation MED8 TNF 11132773 760249 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation MED8 TNF 11159885 781426 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED8 TNF 12524657 1047956 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED8 TNF 14550746 1152732 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED8 TNF 14982858 1214534 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED8 TNF 17307735 1719093 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED8 TNF 17389616 1748451 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation MED8 TNF 17456789 1761132 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation MED8 TNF 17988550 1821512 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED8 TNF 18675993 2011444 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED8 TNF 21904602 2478315 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED8 TNF 23684917 2796495 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED8 TNF 23815148 2849291 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation MED8 TNF 2788206 116810 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED8 TNF 3292408 94753 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED8 TNF 7530746 291696 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation MED8 TNF 7947995 277220 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation MED8 TNF 8453746 215226 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED8 TNF 8679220 372479 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MED8 TNF 9288135 452467 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation MED9 ANGPT1 12890486 1117502 ( 2 ) PLD is a new [mediator] of *induced* signaling pathway , and it participates in MAPK activation and endothelial cell migration . Positive_regulation MED9 ANGPT1 16638932 1589744 We observed that hepatocyte growth factor (HGF) , a [mediator] of mural cell motility , was *up-regulated* by stimulation . Positive_regulation MED9 CD14 16574244 1582692 Elevated circulating levels of LBP and constitutively higher cell surface expression of TLR4 and on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED9 CHI3L1 18802121 1965043 In addition , *induced* [mediator] release from alveolar macrophages was examined . Positive_regulation MED9 EDN2 7693285 231310 *induced* contraction and [mediator] release in human bronchus . Positive_regulation MED9 EDN2 9124581 424113 Activation of receptors in the liver *causes* vasoconstriction , glucose production , and lipid and peptide [mediator] synthesis . Positive_regulation MED9 EPHB2 20138154 2227142 Hirsutenone *inhibits* lipopolysaccharide activated NF-kappaB induced inflammatory [mediator] production by suppressing Toll-like receptor 4 and activation . Positive_regulation MED9 EPHB2 23684917 2796524 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside *inhibits* TNF-a activated NF-?B induced inflammatory [mediator] production by suppressing activation . Positive_regulation MED9 ID1 11278321 798201 We conclude that the novel zinc finger protein Zfp289 , which may represent the mammalian homologue of Gcs-1 , is potentially an important [mediator] of the *induced* proliferation pathway in mammary epithelial cells . Positive_regulation MED9 IL1B 9810029 545638 We have examined the inhibitory effect of 1.8-cineole on LPS-and *stimulated* [mediator] production by human monocytes in vitro . Positive_regulation MED9 ITGB2 9152024 430949 *Activation* of the beta2 ( CD11b/CD18 ) by an endogenous lipid [mediator] of human neutrophils and HL-60 cells . Positive_regulation MED9 LBP 16574244 1582693 Elevated circulating levels of and constitutively higher cell surface expression of TLR4 and CD14 on macrophages in males could *result* in the observed sexual dimorphism in LPS induced inflammatory [mediator] production and the greater susceptibility of males to bacterial sepsis . Positive_regulation MED9 TLR7 19631980 2132005 Therefore , we tested the hypothesis that stimulation of a trophoblast cell line *induces* inflammatory [mediator] production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation MED9 TNF 11159885 781440 Specific disaccharides suppressed spontaneous and *induced* [mediator] secretion in a dose dependent manner . Positive_regulation MED9 TNF 12524657 1047970 Ceramide has been confirmed to be a signal [mediator] of apoptosis that is *induced* by . Positive_regulation MED9 TNF 14550746 1152746 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Positive_regulation MED9 TNF 14982858 1214548 Secretion of from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential [mediator] of the inflammatory response in preeclampsia . Positive_regulation MED9 TNF 17307735 1719107 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Positive_regulation MED9 TNF 17988550 1821526 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Positive_regulation MED9 TNF 18675993 2011486 P38 is a critical [mediator] of BLP *induced* release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation MED9 TNF 21904602 2478329 O-GlcNAc modification of NF?B p65 inhibits *induced* inflammatory [mediator] expression in rat aortic smooth muscle cells . Positive_regulation MED9 TNF 23684917 2796523 Quercetin-3-O- ( 2?-galloyl ) -a-l-rhamnopyranoside inhibits *activated* NF-?B induced inflammatory [mediator] production by suppressing ERK activation . Positive_regulation MED9 TNF 2788206 116824 However , only IL-1 , not TNF or LPS , depressed cytochrome P-450 in cultured hepatocytes , suggesting that the effect of in vivo might be *mediated* by a second [mediator] . Positive_regulation MED9 TNF 3292408 94767 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of , a [mediator] of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation MED9 TNF 8453746 215240 As a proximal [mediator] in the host response to infection-like challenges , may *enhance* glucose metabolism by directly interacting with cells or by initiating a cascade of events leading to changes in glucose production and utilization . Positive_regulation MED9 TNF 8679220 372493 is a potentially important cytokine in allergic respiratory reactions since it is released by mast cells and eosinophils , and it can *promote* [mediator] and cytokine release , adhesion molecule expression , and granulocyte migration . Positive_regulation MEFV ANGPT1 19106103 2036491 Collectively , these findings indicate that signal *stimulates* transcriptional activity of [MEF2] through a PI3K/AKT pathway to induce KLF2 expression , which may counteract VEGF mediated inflammatory responses . Positive_regulation MEFV IL1B 10887141 709998 [MEFV] was expressed in peritoneal and skin fibroblasts at a lower level than in neutrophils and could be further *induced* by PMA and . Positive_regulation MEFV TNF 14514692 1164962 The *induced* expression of [MEFV] is dependent on both NFkappaB p65 and C/EBPbeta that bind to evolutionarily conserved sites located , in the human promoter , at positions -163 and -55 , respectively . Positive_regulation MEFV TNF 14514692 1164964 As shown by a series of transcription and gel shift assays performed with wild-type and mutated promoter sequences , these two transcription factors act differently on the *dependent* transcription of [MEFV] : C/EBPbeta is the key regulatory factor required to confer cell responsiveness to TNFalpha , whereas NFkappaB p65 increases this response by means of a synergistic interaction with C/EBPbeta that is dependent on the integrity of the identified -55 C/EBP binding site . Positive_regulation MEFV TNF 22735261 2634309 Consistently , also *increased* the nuclear [MEF2] expression . Positive_regulation MEFV TNF 22736074 2719268 The *role* of and PAI-1 gene polymorphisms in familial [Mediterranean fever] . Positive_regulation MEFV TNF 8478050 218657 Maximal production of *required* [MEF] gene transcription during the first 6 h of incubation with endotoxin . Positive_regulation MEP1A TNF 22326557 2586499 Finally , *impaired* the ability of CDX2 to interact and activate its own , as well as the [MEP1A] expression . Positive_regulation MEPE IL1B 1888884 165812 Human *caused* a dose- and time dependent enhancement of the release [of 45Ca] from prelabeled mouse calvaria in organ culture . Positive_regulation MEPE IL1B 8227347 235646 In cultures of rabbit growth plate chondrocytes , at 0.1 ng/ml *caused* 95 % decreases in alkaline phosphatase activity , alkaline phosphatase mRNA levels , the incorporation [of 45Ca] into insoluble material , and the calcium content during the hypertrophic stage . Positive_regulation MET EFNB1 19483190 2128375 We conclude that interaction *promotes* [MET] by re-establishing epithelial cell-cell junctions and such an MET promoting effect contributes to EphB3 mediated tumor suppression . Positive_regulation MET FOXO1 15688035 1376229 We demonstrate here that more potently *induces* a [MET] in SaOS-2 cells than Pax3 . Positive_regulation MET FOXO1 9721857 528782 *Up-regulation* of [MET] but not neural cell adhesion molecule expression by the fusion protein in alveolar rhabdomyosarcoma . Positive_regulation MET ID1 24332369 2880529 Furthermore , Id1 is induced by transforming growth factor ( TGF ) -ß only in cells that have first undergone epithelial-to-mesenchymal transition ( EMT ) , demonstrating that EMT is a prerequisite for subsequent *induced* [MET] during lung colonization . Positive_regulation MET MAP2K6 12379223 997126 Stimulation with HGF led to activation of [Met] as well as to *activation* of PI3-K , PKB/Akt , , and the MAP kinases Erk1 and -2 . Positive_regulation MET PLAT 17538930 1751780 One potential mechanism for these effects is that both deficiency and tPA-STOP *reduce* hepatocyte growth factor (HGF) activation and [c-Met] phosphorylation in the liver after BDL . Positive_regulation MET PLAU 12958170 1138185 Here we provide evidence that PGE2 transactivates [c-Met-R] ( contingent upon functional EGFR ) , increases tyrosine phosphorylation and nuclear accumulation of beta-catenin , and *induces* receptor ( uPAR ) mRNA expression . Positive_regulation MET TNF 19530226 2109519 Previously , we showed that [Met] gene expression is *regulated* by . Positive_regulation MET TNF 19530226 2109523 In p65-/- mouse embryonic fibroblasts ( MEFs ) , [Met] *induction* by is abrogated while Met 's basal gene expression is reduced by half as compared to controls . Positive_regulation MET TNF 20628900 2310248 In the *presence* of , [Met] and Cys significantly increased the LPL activity , and Met also enhanced the LPL mRNA level . Positive_regulation MET TNFSF10 21706050 2538788 miR-130a targets [MET] and *induces* in NSCLC by downregulating miR-221 and 222 . Positive_regulation METAP2 CAPN8 1706637 147788 Our results suggest that is partially *involved* in the degradation of [MAP2] , and that the use of calpain inhibitors can be a useful clinical approach to cerebral ischemia . Positive_regulation METAP2 HES2 16916793 1602578 Electrophoretic mobility shift analysis , promoter mutagenesis and co-transfection experiments showed that NeuroD , a pro-neuronal differentiation factor , and ( HES1 ) , a transcription repressor , are *involved* in the regulation of [MAP2] promoter activity . Positive_regulation MFGE8 TNF 17478559 1766587 Insulin and also *up-regulated* [MFG-E8] in the microvesicles . Positive_regulation MGAM GCG 12357042 994161 peptide 2 *enhances* [maltase-glucoamylase] and sucrase-isomaltase gene expression and activity in parenterally fed premature neonatal piglets . Positive_regulation MGP CTGF 18289887 1924836 in contrast , *stimulated* expression of [matrix gla protein] which is known to impair mineralization . Positive_regulation MIA SMN2 22925727 2678351 CLX and *regulated* the [MIA-up] regulated IL-1ß at mRNA level . Positive_regulation MICA EPHB2 23308050 2712562 Activation of constitutively phosphorylated extracellular signal regulated kinase ( ) by VPA is *essential* for the up-regulation of [MICA/B] and ULBP2 expressions . Positive_regulation MICA EPHB2 23308050 2712566 Furthermore , overexpression of constitutively active in ARK *resulted* in increased [MICA/B] and ULBP2 expressions and enhanced NK cell lysis . Positive_regulation MICA TLR7 18981088 1983346 *induced* [MICA] on the monocyte cell surface was detected by autologous NK cells as revealed by NKG2D down-regulation . Positive_regulation MICA TNF 16698439 1560448 Here , we show that IL-2 , IL-4 , and IL-15 but not or IFN-alpha *induced* [MICA] expression in T lymphocytes present in peripheral blood mononuclear cells ( PBMCs ) , as assessed by Western blot . Positive_regulation MICE TNF 1932370 170056 [Mice] are quite resistant to LPS toxicity but even a small dose *induced* a monophasic production of circulating . Positive_regulation MICE TNF 22449555 2577705 [Mice] producing human TNFR2 that can be *activated* by mouse , in addition to mouse TNFR2 , did not demonstrate enhanced susceptibility to the lethal effects of glomerulonephritis , indicating that pro-inflammatory signalling via TNFR2 does not account for a sensitizing effect . Positive_regulation MIF CCND1 15840582 1418287 Our studies reveal that recombinant [MIF] *induces* expression in a Rho- , Rho kinase- , MLC kinase- , and ERK dependent manner in asynchronous NIH 3T3 fibroblasts . Positive_regulation MIF EPHB2 16122907 1507326 By contrast , JAB1-knock-down by siRNA revealed that minimum JAB1 levels were necessary for transient *activation* of by [MIF] . Positive_regulation MIF EPHB2 23252627 2737267 These changes were associated with up-regulation of [MIF] and its receptor CD74 *activation* of ( extracellular-signal regulated kinase ) and NF-?B ( nuclear factor ?B ) signalling , prominent macrophage and T-cell infiltration , as well as up-regulation of Th1 [ T-bet and IFN? ( interferon ? ) ] and Th17 [ STAT3 ( signal transducer and activator of transcription 3 ) and IL ( interleukin)-17A ] as well as IL-1ß and TNFa ( tumour necrosis factor a ) . Positive_regulation MIF IL1B 10446857 636782 Synoviocyte [MIF] was not *increased* by , TNFalpha , or IFNgamma . Positive_regulation MIF IL1B 15901641 1445633 Curcumin ( 10 ( -8 ) M ) , which is known for inhibiting NFkappaB activation , inhibited *induced* [MIF] secretion as well as NFkappaB nuclear translocation and DNA binding . Positive_regulation MIF IL1B 16402640 1494685 [MIF] and endotoxin were *detected* in the fluid of all samples , whereas and RANTES were detected in 1 and 3 subjects out of 12 samples . Positive_regulation MIF TF 11967015 933027 *up-regulated* monocyte chemoattractant peptide-1 , interleukin-8 , and [macrophage migration inhibitory factor] expression in a time- and dose dependent fashion , but had no effect on RANTES expression by PTEC . Positive_regulation MIF TLR7 22127710 2515000 We also measured MIF plasma levels in relation to genotypes and clinical phenotypes , and assessed *stimulated* [MIF] production in vitro . Positive_regulation MIF TLR7 22968741 2719908 Plasma MIF levels and *stimulated* [MIF] production also reflect the underlying MIF genotype . Positive_regulation MIF TNF 10068127 594066 [MIF-A3] does induce secretion of IL-6 , but does not *induce* secretion of , IL-1beta , and GM-CSF . Positive_regulation MIF TNF 10446857 636780 Synoviocyte [MIF] was not *increased* by IL-1beta , , or IFNgamma . Positive_regulation MIF TNF 11086030 750833 The catabolic effect of on myotubes was *mediated* by [MIF] , which served as an autocrine stimulus for F2 , 6BP production . Positive_regulation MIF TNF 12635141 1068486 [MIF] *induced* significant MIF and synthesis in cultured endothelial cells and the effect was blocked by neutralizing anti-MIF antibody . Positive_regulation MIF TNF 12635141 1068488 A similar blocking effect was observed when MIF stimulated endothelial cells were pretreated with neutralizing anti-TNF-alpha antibody or glucocorticoid , supporting the notion that [MIF] *induced* production via an amplifying pro-inflammatory loop . Positive_regulation MIF TNF 12738641 1087982 [MIF] was *detected* in 97.9 % of the MEEs from adults , while endotoxin , IL-1beta , , and RANTES were detected in 96.8 , 12.6 , 5.3 , and 43.9 % , respectively . Positive_regulation MIF TNF 16210389 1507849 Results from enzyme linked immunosorbent assay ( ELISA ) demonstrated a significant dose- and time dependent increase in [MIF] secretion by human endometrial cells in *response* to ( 0.1-100 ng/ml ) . Positive_regulation MIF TNF 16210389 1507851 The expression of a dominant negative NF-kappaB inhibitor ( IkappaB ) significantly decreased the *induced* [MIF] promoter activity as analysed by transient cell transfection . Positive_regulation MIF TNF 16861224 1607275 Apoptotic neutrophils release [macrophage migration inhibitory factor] upon *stimulation* with . Positive_regulation MIF TNF 19406662 2082393 Pathogenic bacteria and do not *induce* production of [macrophage migration inhibitory factor] ( MIF ) by human monocytes . Positive_regulation MIF TNF 20830230 2318833 [MIF] was also *induced* by interferon-? , CD40 ligand , interleukin-15 , interleukin-1ß , , and transforming growth factor-ß . Positive_regulation MIF TNF 21269946 2380767 ADMA can up-regulate [MIF] expression and *induce* and IL-8 secretion in THP-1 monocyte derived macrophages . Positive_regulation MIF TNF 7683323 216432 [MIF] and IFN-gamma synergize with lipid A to mediate migration inhibition but only IFN-gamma *induces* production of and nitric oxide . Positive_regulation MIF TNF 7947826 277200 [MIF] *induced* the secretion of and stimulated nitric oxide production by macrophages primed with interferon-gamma . Positive_regulation MIF TNF 8195715 259180 In RAW 264.7 macrophages , [MIF] secretion also was *induced* by and IFN-gamma , but not by interleukins 1 beta or 6 . Positive_regulation MIF TNF 9085256 421496 In addition , *regulates* systemic [MIF] production . Positive_regulation MIF TNF 9196042 438467 The results showed that [MIF] content was 1.6 +/- 0.48 ng/ml ( mean +/- SD ) after 24 hr culture , and the content was *increased* up to 9.7 +/- 2.8 ng/ml by stimulation with ( 50 nM ) . Positive_regulation MIF TNF 9538268 497740 *regulates* the gene expression of [macrophage migration inhibitory factor] through tyrosine kinase dependent pathway in 3T3-L1 adipocytes . Positive_regulation MIF TNF 9538268 497743 This observation indicates that *stimulates* [MIF] secretion from the constitutively expressed intracellular pool of 3T3-L1 adipocytes and promotes de novo synthesis of MIF . Positive_regulation MIF TNF 9538268 497744 The results suggest the possibility that *upregulation* of [MIF] mRNA expression by is mediated by a tyrosine kinase dependent pathway . Positive_regulation MIP EDN1 20952681 2343677 Moreover , *induced* [MIP-1ß] mRNA expression in either THP-1 cells or peripheral blood monocytes was reduced upon expression of microRNA-195a . Positive_regulation MIP EGR1 19303658 2064325 RAGE mediated increased expression of *upregulates* a central downstream gene , [MIP2] . Positive_regulation MIP EPHB2 12821152 1104165 These results suggest that activation of is *involved* in the production of [MIP-2] on coculturing of macrophages with late apoptotic cells . Positive_regulation MIP EPHB2 15145928 1267558 Lens major intrinsic protein [(MIP)/aquaporin 0] expression in rat lens epithelia explants *requires* fibroblast growth factor induced and JNK signaling . Positive_regulation MIP FASLG 12466142 1022334 Alternatively , the combined loss of and TLR-4 did not *inhibit* the increase in MPO and exacerbated lung [IL-6/MIP-2] levels even further . Positive_regulation MIP FGF2 15145928 1267562 Specific inhibitors , UO126 for ERK1/2 and SP600125 for JNK , abrogated [Mip] expression in *response* to in the explants . Positive_regulation MIP FGF2 20478381 2276113 In this study , we demonstrate that exogenous KYN reduces *mediated* expression of alpha- , beta- , and gamma-crystallin and [MIP26] in mLEC . Positive_regulation MIP GRAP2 23666384 2909138 Topical MAPK inhibitor *attenuated* dermal interleukin (IL)-6 , [MIP-2] , and IL-1ß expression and plasma IL-6 and MIP-2 cytokine expression . Positive_regulation MIP IFNG 12011029 941369 These data indicate that *mediates* the induction of [MIP-2] and iNOS mRNA expression by H. pylori in mice . Positive_regulation MIP IL17A 20957005 2333530 was produced early in airway upon Chlamydia trachomatis , and rmIL-17could *induce* IL-6 and [MIP-2] production in L929 cells after infection with MoPn . Positive_regulation MIP IL1B 16055671 1466209 Both differentiated and dedifferentiated type II cells secreted [MIP-2] , MCP-1 , and CINC-2 in *response* to a cytokine mixture of IL-1beta , TNF-alpha , and IFN-gamma or to alone . Positive_regulation MIP IL1B 17015748 1629893 *induced* increased mRNA levels of [MIP-2] , MCP-1 , RANTES , inducible NO synthase (iNOS) , and cyclooxygenase-2 (COX-2) in the IEC-18 cell line . Positive_regulation MIP IL1B 9294201 452922 However , lipopolysaccharide and *induced* [MIP-2] expression . Positive_regulation MIP ITGB2 11069084 747701 Cross linking of *induces* secretion of [macrophage inflammatory protein (MIP)-lalpha] and MIP-1beta with consequent directed migration of activated lymphocytes . Positive_regulation MIP JUN 14597166 1160381 In summary , our data suggest that both NF-kappaB and *contribute* to LPS induced mouse [MIP-2] gene expression in RAW 264.7 cells . Positive_regulation MIP JUN 18452653 1902983 ELISA based transcription factor activation assays and chromatin immunoprecipitation assays revealed that functional interaction between and MIP-2 promoter element is *necessary* for [MIP-2] gene expression by DNFB . Positive_regulation MIP LPA 21464938 2412919 LPA5 is a bona fide receptor on human mast cells responsible for the majority of LPA *induced* [MIP-1ß] release . Positive_regulation MIP MAF 17262012 1691335 Misexpression of and c-Maf *induces* ectopic expression of Cx43 and [MIP] ; Positive_regulation MIP MAPK1 23666384 2909139 Topical p38 inhibitor *attenuated* dermal interleukin (IL)-6 , [MIP-2] , and IL-1ß expression and plasma IL-6 and MIP-2 cytokine expression . Positive_regulation MIP MAPK10 23666384 2909140 Topical p38 inhibitor *attenuated* dermal interleukin (IL)-6 , [MIP-2] , and IL-1ß expression and plasma IL-6 and MIP-2 cytokine expression . Positive_regulation MIP MAPK11 23666384 2909141 Topical p38 inhibitor *attenuated* dermal interleukin (IL)-6 , MIP-2 , and IL-1ß expression and plasma IL-6 and [MIP-2] cytokine expression . Positive_regulation MIP MAPK12 23666384 2909142 Topical p38 inhibitor *attenuated* dermal interleukin (IL)-6 , [MIP-2] , and IL-1ß expression and plasma IL-6 and MIP-2 cytokine expression . Positive_regulation MIP MAPK13 23666384 2909143 Topical p38 inhibitor *attenuated* dermal interleukin (IL)-6 , MIP-2 , and IL-1ß expression and plasma IL-6 and [MIP-2] cytokine expression . Positive_regulation MIP MAPK14 23666384 2909144 Topical p38 inhibitor *attenuated* dermal interleukin (IL)-6 , [MIP-2] , and IL-1ß expression and plasma IL-6 and MIP-2 cytokine expression . Positive_regulation MIP MAPK15 23666384 2909137 Topical p38 inhibitor *attenuated* dermal interleukin (IL)-6 , [MIP-2] , and IL-1ß expression and plasma IL-6 and MIP-2 cytokine expression . Positive_regulation MIP MAPK3 23666384 2909145 Topical p38 inhibitor *attenuated* dermal interleukin (IL)-6 , MIP-2 , and IL-1ß expression and plasma IL-6 and [MIP-2] cytokine expression . Positive_regulation MIP MAPK4 23666384 2909146 Topical p38 inhibitor *attenuated* dermal interleukin (IL)-6 , [MIP-2] , and IL-1ß expression and plasma IL-6 and MIP-2 cytokine expression . Positive_regulation MIP MAPK6 23666384 2909147 Topical p38 inhibitor *attenuated* dermal interleukin (IL)-6 , MIP-2 , and IL-1ß expression and plasma IL-6 and [MIP-2] cytokine expression . Positive_regulation MIP MAPK7 23666384 2909148 Topical p38 inhibitor *attenuated* dermal interleukin (IL)-6 , [MIP-2] , and IL-1ß expression and plasma IL-6 and MIP-2 cytokine expression . Positive_regulation MIP MAPK8 23666384 2909149 Topical p38 inhibitor *attenuated* dermal interleukin (IL)-6 , MIP-2 , and IL-1ß expression and plasma IL-6 and [MIP-2] cytokine expression . Positive_regulation MIP MAPK9 23666384 2909150 Topical p38 inhibitor *attenuated* dermal interleukin (IL)-6 , [MIP-2] , and IL-1ß expression and plasma IL-6 and MIP-2 cytokine expression . Positive_regulation MIP MIPEP 16148459 1455195 High tidal volume ventilation *induced* messenger RNA expression , [MIP-2] protein production , neutrophil migration into the lung , airway epithelial cell apoptosis , and activation of ASK1 , JNK , and activator protein (AP)-1 DNA binding in a dose dependent and time dependent manner . Positive_regulation MIP MPO 22728595 2616781 Our results demonstrate that *regulates* the production of [MIP-2] , which may modulate neutrophil accumulation during lung inflammation . Positive_regulation MIP NFKB1 14597166 1160382 In summary , our data suggest that both and c-Jun *contribute* to LPS induced mouse [MIP-2] gene expression in RAW 264.7 cells . Positive_regulation MIP NFKB1 16585588 1544248 In contrast , inhibition *reduced* [MIP-2] expression and neutrophil influx following P. aeruginosa infection . Positive_regulation MIP NOS2 22831879 2676834 Inhibition of activity in WT mice with L-Nil *suppressed* burn wound levels of IL-1ß , G-CSF , and [MIP-1a] , whereas IL-6 , TNF-a , KC , MCP-1 and MIP-1ß were unaffected . Positive_regulation MIP NOX1 17704189 1822339 O ( 2 ) ( *- ) generation was necessary for macrophage inflammatory protein-2 ( MIP-2 ) gene expression , because inhibition of or the mitochondrial respiratory chain or overexpression of Cu , Zn-superoxide dismutase significantly *inhibited* expression of [MIP-2] . Positive_regulation MIP NOX3 17704189 1822340 O ( 2 ) ( *- ) generation was necessary for macrophage inflammatory protein-2 ( MIP-2 ) gene expression , because inhibition of or the mitochondrial respiratory chain or overexpression of Cu , Zn-superoxide dismutase significantly *inhibited* expression of [MIP-2] . Positive_regulation MIP NOX4 17704189 1822341 O ( 2 ) ( *- ) generation was necessary for macrophage inflammatory protein-2 ( MIP-2 ) gene expression , because inhibition of or the mitochondrial respiratory chain or overexpression of Cu , Zn-superoxide dismutase significantly *inhibited* expression of [MIP-2] . Positive_regulation MIP NOX5 17704189 1822338 O ( 2 ) ( *- ) generation was necessary for macrophage inflammatory protein-2 ( MIP-2 ) gene expression , because inhibition of or the mitochondrial respiratory chain or overexpression of Cu , Zn-superoxide dismutase significantly *inhibited* expression of [MIP-2] . Positive_regulation MIP PAM 20403209 2255842 Both LPS and significantly *increased* [MIP-2] and TNFalpha mRNA expression compared to sham challenge ( P < 0.05 ) . Positive_regulation MIP PTPN22 17114487 1651627 Both in vitro and in mice , *induced* [MIP-2/IL-8] , TNF-alpha , and IL-1beta , all mediators of neutrophil recruitment and activation . Positive_regulation MIP RELA 14597166 1160383 In summary , our data suggest that both and c-Jun *contribute* to LPS induced mouse [MIP-2] gene expression in RAW 264.7 cells . Positive_regulation MIP RELA 16585588 1544249 In contrast , inhibition *reduced* [MIP-2] expression and neutrophil influx following P. aeruginosa infection . Positive_regulation MIP STAT3 23024284 2702440 G-CSF activated *enhances* production of the chemokine [MIP-2] in bone marrow neutrophils . Positive_regulation MIP TAT 22187158 2585853 Among an array of NF-?B-responsive genes , mostly *activated* the [MIP-1a] expression in a p65 dependent manner , and bound to the MIP-1a NF-?B enhancer thus promoting the recruitment of p65 with displacement of I?B-a ; Positive_regulation MIP TLR4 12091428 960147 These findings demonstrate that endotoxin induced keratitis is regulated by *dependent* expression of PECAM-1 and [MIP-2] , which are essential for recruitment of neutrophils to this site and for development of endotoxin induced stromal disease . Positive_regulation MIP TLR4 12466142 1022333 Alternatively , the combined loss of FasL and did not *inhibit* the increase in MPO and exacerbated lung [IL-6/MIP-2] levels even further . Positive_regulation MIP TNF 10362723 620141 The results support the hypothesis that *mediates* cristobalite induced MCP-1 and [MIP-2] expression through the generation of ROS . Positive_regulation MIP TNF 11580144 865452 These findings suggest that Con A induces TNF-alpha release , and this *stimulates* [MIP-2] induction , at least partially contributing to the liver injury mediated through the recruitment of neutrophils . Positive_regulation MIP TNF 19231998 2072045 Interleukin-1beta pretreatment enhanced *induced* [macrophage inflammatory protein (MIP)-2] and KC mRNA expression as well as MIP-2 and KC protein levels at the same time point analyzed . Positive_regulation MIP TNF 8597099 342603 Since previous studies had demonstrated that *stimulates* [MIP-2] and CINC expression in vitro and that particle exposure induces TNF alpha production in rat lung we examined the role of TNF alpha in alpha quartz induced MIP-2 gene expression . Positive_regulation MIP ZFP36 17392586 1665331 Down-regulation of expression *results* in enhanced IL-12 and [MIP-2] production and reduced MIP-3alpha synthesis in activated macrophages . Positive_regulation MIPEP EPHB2 12821152 1104163 We then examined whether or not activation is *involved* in the production of [MIP-2] by employing selective inhibitors for MAP kinase kinase 1/2 , PD98059 , and U0126 . Positive_regulation MIPEP EPHB2 15145928 1267559 Lens [major intrinsic protein (MIP)/aquaporin] 0 expression in rat lens epithelia explants *requires* fibroblast growth factor induced and JNK signaling . Positive_regulation MIPEP IL1B 10861753 705328 After 4 weeks of treatment with E ( 2 ) + DHT , a significant increase in transcript levels of IL-4 , IL-5 , IL-6 , [MIP-2] , eotaxin , and iNOS was *detected* , while and TNF-alpha transcript levels only increased slightly . Positive_regulation MIPEP IL1B 11259370 795858 Further characterization of MIP-2 regulation by Northern blot analysis confirmed an NO- and *dependent* increase in [MIP-2] mRNA levels . Positive_regulation MIPEP IL1B 15518718 1328729 *increased* the release of CINC and [MIP-2] into culture media in a dose- and time dependent manner . Positive_regulation MIPEP IL1B 16239643 1508321 Both cell phenotypes secreted [MIP-2] and MCP-1 in *response* to or lipopolysaccharide , but there was no priming or synergy with ozone . Positive_regulation MIPEP IL1B 19002429 2022195 *induced* a time dependent increase in Mcp-1 and [Mip-2] ( also known as Cxcl2 ) mRNA expression after 6 h of stimulation in insulinoma (INS)-1 and neonatal rat islet cells . Positive_regulation MIPEP IL1B 8553267 339971 A study was performed to determine whether could *induce* the expression of [MIP-2] in the lungs of Brown-Norway rats . Positive_regulation MIPEP ITGB2 9759893 536642 As expected , cross linking of on macrophages with Ab *resulted* in generation of TNF-alpha and [MIP-2] . Positive_regulation MIPEP MIP 16148459 1455198 High tidal volume ventilation *induced* [MIP-2] messenger RNA expression , protein production , neutrophil migration into the lung , airway epithelial cell apoptosis , and activation of ASK1 , JNK , and activator protein (AP)-1 DNA binding in a dose dependent and time dependent manner . Positive_regulation MIPEP TNF 10502561 648779 also *induced* [MIP-2] production from alveolar epithelial cells . Positive_regulation MIPEP TNF 10502561 648780 These results suggest that LPS induced [MIP-2] release from alveolar epithelial cells may be *mediated* in part by from the same cell type . Positive_regulation MIPEP TNF 10799303 691107 These data demonstrate that *induces* expression of [MIP-2] in endothelial cells and support the hypothesis that the anti-inflammatory action of dexamethasone may , at least in part , be attributable to an inhibition of MIP-2 induction on cytokine activated endothelial cells . Positive_regulation MIPEP TNF 10861753 705327 After 4 weeks of treatment with E ( 2 ) + DHT , a significant increase in transcript levels of IL-4 , IL-5 , IL-6 , [MIP-2] , eotaxin , and iNOS was *detected* , while IL-1beta and transcript levels only increased slightly . Positive_regulation MIPEP TNF 10861785 705333 Stimulation of MVEC and astrocytes with simultaneously *induced* the release of [MIP-2] reaching saturation by 4-8 hr and of sICAM-1 increasing continuously from 2-4 hr to 12 hr. Augmented sICAM-1 production correlated with enhanced membrane bound ( m ) ICAM-1 expression in both cell types ( r ( s ) = 0.96 and 0.90 , P < 0.0001 ) , but was markedly higher in astrocytes . Positive_regulation MIPEP TNF 10861785 705335 If added together , sICAM-1 and synergistically *induced* [MIP-2] production suggesting the involvement of two different pathways for MIP-2 regulation . Positive_regulation MIPEP TNF 11200059 779756 Inclusion of IL-10 neutralizing antibody in the culture medium significantly ( p < 0.05 ) enhanced *induced* IL-6 and [MIP-2] production by both corneal cell types . Positive_regulation MIPEP TNF 11948246 930092 By contrast , *induction* of [MIP-2] by involved both p42/44 MAPK and p38 MAPK . Positive_regulation MIPEP TNF 15134897 1245816 These results indicate that IL-17 up-regulates elaboration of various proangiogenic factors , and modulates macrophage derived *induced* production of KC , [MIP-2] , PGE2 and VEGF by fibroblasts . Positive_regulation MIPEP TNF 16436136 1516397 Either SCF or TNF-alpha could induce release from HMC-1 cells of interleukin (IL)-8 , monocyte chemoattractant protein (MCP)-1 , regulated upon activation normal T-cell expressed and secreted ( RANTES ) , and I-309 , while SCF and *induced* release of [macrophage inflammatory protein (MIP)-1beta] and interferon-gamma-inducible protein-10 (IP-10) , respectively . Positive_regulation MIPEP TNF 19231998 2072046 Interleukin-1beta pretreatment enhanced *induced* macrophage inflammatory protein (MIP)-2 and KC mRNA expression as well as [MIP-2] and KC protein levels at the same time point analyzed . Positive_regulation MIPEP TNF 20621170 2310027 This response was maximized by the PM10 that *induced* a significant increase in [MIP-2] , , and HO-1 . Positive_regulation MIPEP TNF 8383510 212311 Rat alveolar macrophage MIP-1 alpha and [MIP-2] mRNA expression was also *increased* by and adherence to plastic . Positive_regulation MIPEP TNF 9112332 425807 In addition , FA as well as DX reduced [MIP-2] production *induced* by . Positive_regulation MIPEP TNF 9841832 581795 [MIP-1] levels were not *diminished* by inhibiting circulating in humans . Positive_regulation MIR10B CTGF 22020939 2516629 Cysteine-rich <61-connective tissue growth factor-nephroblastoma> overexpressed 5 ( CCN5 ) /Wnt-1 induced signaling protein-2 ( WISP-2 ) *regulates* [microRNA-10b] via hypoxia-inducible factor-1a-TWIST signaling networks in human breast cancer cells . Positive_regulation MIR122 TNF 21763238 2484436 *caused* a rapid increase in expression of [microRNA (miR)-122a] in enterocytes , cultured cells , and intestinal tissue . Positive_regulation MIR155 TNF 20948191 2343640 IFN-? and synergistically *induce* [microRNA-155] which regulates TAB2/IP-10 expression in human mesangial cells . Positive_regulation MIR155HG TNF 24769202 2937005 Moreover , *increased* [MIR155HG] expression and promoter activity as well as miR-155 biogenesis , and these increases were blocked by NF-?B inhibitors . Positive_regulation MIR21 EPHB2 23473787 2766454 [MiR-21] *involve* in mediated upregulation of MMP9 in the rat hippocampus following cerebral ischemia . Positive_regulation MIR21 TNF 23710745 2792798 [MicroRNA-21] reduced *induced* cardiomyocytes apoptosis [ ( 23.42 ± 1.98 ) % vs. ( 78.37 ± 2.03 ) % , P < 0.05 ] . Positive_regulation MITF EPHB2 23728343 2932267 Reduction of MITF protein levels was the result of proteasomal degradation , which was preceded by enhanced phosphorylation of [MITF] *mediated* by . Positive_regulation MITF PGC 23201126 2724067 The in turn *activate* the [MITF] promoter , and their expression correlates strongly with that of MITF in human melanoma cell lines and biopsy specimens . Positive_regulation MITF PGC 23201126 2724073 Inhibition of PGC-1a and *blocks* the a-MSH mediated induction of [MITF] and melanogenic genes . Positive_regulation MITF WIF1 24131586 2889342 The upregulation of on cultured normal human melanocytes significantly *induced* expressions of [MITF] and tyrosinase , which were associated with increased melanin content and tyrosinase activity . Positive_regulation MKL1 EPHB2 15292266 1303133 Taken together these results demonstrate that S1P activates multiple signaling pathways in SMC and regulates proliferation by *dependent* activation of Elk-1 and differentiation by RhoA dependent activation of [MRTF-A] . Positive_regulation MKNK1 EPHB2 14605021 1176300 PD98059 or introduction of kinase-inactive MEK1/MKK1 , but not SB202190 or kinase-inactive p38 MAP kinase , inhibited Ang II-induced Mnk1 activation and eIF4E phosphorylation , suggesting that , but not p38 MAP kinase , is *required* for Ang II-induced [Mnk1-eIF4E] activation . Positive_regulation MKNK1 EPHB2 15447679 1300460 NMDA receptor activation results in PKA- and *dependent* [Mnk1] activation and increased eIF4E phosphorylation in hippocampal area CA1 . Positive_regulation MKNK1 IL1B 9155018 431572 Further , [MNK1] was activated upon *stimulation* of HeLa cells with 12-O-tetradecanoylphorbol-13-acetate , fetal calf serum , anisomycin , UV irradiation , tumor necrosis factor-alpha , , or osmotic shock , and the activation by these stimuli was differentially inhibited by the MEK inhibitor PD098059 or the p38 MAP kinase inhibitor SB202190 . Positive_regulation MLC1 CAPN8 21889269 2521914 As a *consequence* of <µ-calpain> proteolysis , [MLC1] is rapidly released from the myofibril and is a potential indicator of proteolysis and improvement in beef tenderness . Positive_regulation MLKL TNF 24366341 2895241 Both the HBD* mediated and *induced* complexes of MLKL ( ND ) or [MLKL] are tetramers , and translocation of these complexes to lipid rafts of the plasma membrane precedes cell death . Positive_regulation MLS TP63 16224147 1469401 To obtain new insights into the *role* of in [malignant lymphomas (MLs)] , immunohistochemical staining for p63 and p53 was performed in 126 cases of MLs . Positive_regulation MLST8 EPHB2 21289294 2419951 Previous studies have shown that , in part , Akt and *promote* [mTORC1] signaling through phosphorylation of a GTPase activator protein (GAP) , referred to as tuberous sclerosis complex 2 (TSC2) , that acts as an upstream inhibitor of mTORC1 . Positive_regulation MLST8 EPHB2 21659537 2459588 Our data also reveal striking diversity in the *requirements* for in the control of [mTORC1] between different cell types , pointing to additional signaling connections between phorbol esters and mTORC1 , which do not involve MEK/ERK . Positive_regulation MLST8 EPHB2 23431403 2744413 Absence of kinase suppressor of Ras 1 (KSR1) , a scaffold protein of the ERK signaling pathway , or inhibition of *resulted* in decreased [mTORC1] activity following T cell activation . Positive_regulation MLST8 MAP2K6 21659537 2459551 Previous work indicated that [mTORC1] activation by the phorbol ester PMA ( phorbol 12-myristate 13-acetate ) depends upon PKCs and may *involve* . Positive_regulation MLST8 MAP2K6 21659537 2459594 Our data also reveal striking diversity in the *requirements* for in the control of [mTORC1] between different cell types , pointing to additional signaling connections between phorbol esters and mTORC1 , which do not involve MEK/ERK . Positive_regulation MLST8 MAP2K6 21738705 2452319 Inhibition of with drugs *caused* only modest [mTORC1] inhibition , implying that other unidentified pathways also play major roles . Positive_regulation MME IL1B 7775337 308920 We examined whether this was mediated through the inhibition of [neutral endopeptidase (NEP)] activity and/or through the *enhancement* of airway microvascular leakage ( AML ) by . Positive_regulation MME ITGB2 9682953 521395 The results from the biocompatibility tests demonstrated that the cleaner [SFE] treated prosthesis *induced* significantly lower expression than the scoured control fabric , and was also associated with a milder inflammatory response and a more rapid rate of healing during the 30 day animal trial . Positive_regulation MME TNF 8380249 210124 In contrast , cultured pleural mesothelial cells had much lower levels of [NEP] than fibroblasts , and the enzyme was not *enhanced* by either IL-1 or . Positive_regulation MMP1 CAPN8 21911754 2496922 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP1 CAPN8 21964156 2525700 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP1 CAPN8 22316244 2553206 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP1 CD14 18180316 1856481 Finally , studies using anti-CD14 neutralizing antibody showed that expression is *essential* for the enhancement of LPS stimulated [MMP-1] expression by high glucose . Positive_regulation MMP1 CTGF 18632843 1979310 In conclusion , upregulation of inhibits BMP-7 signal transduction in the diabetic kidney and *contributes* to altered gene transcription , reduced [MMP] activity , glomerular basement membrane thickening , and albuminuria , all of which are hallmarks of diabetic nephropathy . Positive_regulation MMP1 CTGF 23827951 2820815 stimulation *resulted* in the significant production of IL-6 , IL-8 , C-C motif ligand 2 (CCL2) , CCL20 , [MMP-1] and MMP-3 in FLSs in the presence , but not in the absence , of IL-1ß . Positive_regulation MMP1 EPHB2 12826666 1134611 Studies with specific inhibitors of MAPKs showed that p38 MAPK activation was necessary for both IL-1 beta and MMP-1 induction , but activation was *required* only for [MMP-1] induction . Positive_regulation MMP1 EPHB2 14634122 1170897 Pharmacologic inhibitors of *inhibited* [MMP-1] , but not MMP-13 expression . Positive_regulation MMP1 EPHB2 14634122 1170910 Our data indicate that : 1 ) activation *mediates* [MMP-1] but not MMP-13 release from FLSCs , 2 ) COX-2 derived E PGs inhibit MMP-1 release from FLSCs via inhibition of ERK , and 3 ) COX inhibitors , by attenuating PGE inhibition of ERK , enhance the release of MMP-1 by FLSC . Positive_regulation MMP1 EPHB2 14709335 1196636 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP1 EPHB2 15640153 1381317 [MMP-1] secretion *required* activation of the MAPK and subsequent protein synthesis but was down-regulated by the alternate MAPK , p38 . Positive_regulation MMP1 EPHB2 16413539 1514339 We found that UV irradiation increases [MMP-1] expression and that this is *mediated* by and JNK activation , but not by p38 activation . Positive_regulation MMP1 EPHB2 16453302 1540714 Interleukin-1 beta induction of [matrix metalloproteinase-1] transcription in chondrocytes *requires* dependent activation of CCAAT enhancer binding protein-beta . Positive_regulation MMP1 EPHB2 16468044 1573943 Inhibitors of and NFkappaB could significantly *block* the induction of [MMP-1] and -13 ( p < 0.05 ) and the repression of collagen type II ( p < 0.01 ) . Positive_regulation MMP1 EPHB2 20102637 2213039 Chondrosarcoma cell invasion is increased by hypoxia induced expression of CXCR4 and [MMP1] and is *mediated* by HIF-1a and . Positive_regulation MMP1 EPHB2 20843518 2353052 DPP-4 ( CD26 ) inhibitor alogliptin inhibits TLR4 mediated ERK activation and *dependent* [MMP-1] expression by U937 histiocytes . Positive_regulation MMP1 EPHB2 20843518 2353059 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and *dependent* [MMP] expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation MMP1 EPHB2 21165206 2356694 Furthermore , the inhibition of or JNK with specific chemical inhibitors *prevented* MßCD induced [MMP-1] expression , which indicates that ERK and JNK play an important role in cholesterol depletion mediated MMP-1 induction . Positive_regulation MMP1 EPHB2 21757573 2515924 In particular , the inhibitor but not JNK or p38 MAPK inhibitor *attenuated* the force mediated stimulation of NF-?B-DNA binding and [MMP-1] expression . Positive_regulation MMP1 EPHB2 24012928 2862346 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an [MMP] *inhibitor* , or PD98059 ( 50 µM ) , an inhibitor , also suppressed it . Positive_regulation MMP1 F2R 18988801 1989841 It is currently unknown whether [MMP-1] *activation* of induces angiogenesis in a similar or different manner compared with thrombin . Positive_regulation MMP1 F2R 21909684 2574442 However , it is currently unknown whether [MMP-1] *activation* of has relevance to the progression of hepatocellular carcinoma ( HCC ) . Positive_regulation MMP1 FOXO1 19675556 2119684 Furthermore , *induced* opposite changes in COLIAI , [MMP-1] , and MMP-2 expression . Positive_regulation MMP1 HBEGF 17656145 1793678 Histamine and *caused* a dose dependent release of [MMP-1] with maximal responses that were 2.7- and 4.5-fold greater , respectively , than control , P < 0.001 . Positive_regulation MMP1 HBEGF 17656145 1793680 MAPK inhibition also prevented histamine-and *induced* [MMP-1] secretion . Positive_regulation MMP1 IGFBP1 15590975 1346148 Cell numbers were increased only by 100 nM IGFBP-1 isoforms ( P < 0.05 ) , whereas [MMP] levels released from term cells were optimally *increased* by 1-10 nM . Positive_regulation MMP1 IL1B 10660603 664590 By contrast , the *mediated* increase in [MMP-1] and MMP-3 protein levels could not be suppressed by rapamycin . Positive_regulation MMP1 IL1B 10688614 670018 Finally , IL-13 inhibited *induced* [matrix metalloproteinase (MMP)-1] and MMP-3 production and enhanced tissue inhibitor of metalloproteinase ( TIMP ) -1 generation from NF ; Positive_regulation MMP1 IL1B 10727770 678118 and TPA alone *induced* [MMP] activity in HIG-82 cells . Positive_regulation MMP1 IL1B 10836722 698056 Our findings revealed that amlodipine , but not nifedipine , inhibits *induced* [MMP-1] expression in human ECs . Positive_regulation MMP1 IL1B 10864917 705827 and TNF-alpha each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP1 IL1B 10895370 711601 In support of this result , stimulation *induced* the expression of membrane type matrix-metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation MMP1 IL1B 11056661 580912 In contrast , 1alpha,25 ( OH ) ( 2 ) D ( 3 ) had a slight stimulatory effect on basal production of MMPs 1 and 3 by monolayer cultures of HACs , but *stimulation* of [MMP-1] by was not affected by the simultaneous addition of 1alpha,25 ( OH ) ( 2 ) D ( 3 ) whilst MMP-3 production was enhanced ( Table 1 ) . Positive_regulation MMP1 IL1B 11179516 784766 Transmodulation of epidermal growth factor receptor mediates *induced* [MMP-1] expression in cultured human keratinocytes . Positive_regulation MMP1 IL1B 11179516 784767 In this study , we investigated the pathway that leads to the *induced* up-regulation of [MMP-1] in human keratinocytes . Positive_regulation MMP1 IL1B 11179516 784788 EGF receptor kinase inhibitor PD153035 and AG1478 and MEK inhibitor PD98059 also blocked *induction* of [MMP-1] in cultured human keratinocytes . Positive_regulation MMP1 IL1B 11179516 784796 Collectively , our data indicate that *induced* expression of [MMP-1] is mediated by transactivation of EGF receptor and through ERK pathway in human keratinocytes . Positive_regulation MMP1 IL1B 11285378 799854 , but not rHu-IL-18 , *induced* [interstitial collagenase] ( MMP-1 ) in FLS . Positive_regulation MMP1 IL1B 11327259 807563 A decrease in IL-1alpha , , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP1 IL1B 11467889 840786 While *up-regulated* [MMP-1] , -3 , -9 and -13 , it had no significant effect on expression of either TIMP . Positive_regulation MMP1 IL1B 11467889 840792 In all cases , PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on *induction* of [MMP] expression . Positive_regulation MMP1 IL1B 11502752 868386 The results showed that Smad3 and Smad4 , but not Smad1 or Smad2 , mimicked the inhibitory effect of TGF-beta and abrogated *induced* stimulation of [MMP-1] promoter activity and NFkappaB-specific gene transcription in dermal fibroblasts . Positive_regulation MMP1 IL1B 11585122 865975 Furthermore , fluprostenol , a specific FP receptor agonist , increased MMP-1 production and induced a synergistic enhancement of *induced* [MMP-1] production in HGF , similar to PGF2alpha . Positive_regulation MMP1 IL1B 11585122 865977 Northern blot analysis revealed that PGF2alpha enhanced MMP-1 mRNA expression in HGF and that PGF2alpha increased [MMP-1] mRNA levels *induced* by . Positive_regulation MMP1 IL1B 11732857 885244 *induced* the expressions of [MMP-1] , MMP-13 , and GLS mRNAs and proteins in a dose dependent manner . Positive_regulation MMP1 IL1B 11869069 918206 PPARgamma activators ( 15d-PGJ ( 2 ) and BRL 49653 ) inhibited *induced* [MMP-1] synthesis in a dose dependent manner . Positive_regulation MMP1 IL1B 11962753 932658 A close analysis by immunofluorescence microscopy and western blot analysis showed that Hox alpha and 13-HOTrE significantly suppressed *induced* expression of [matrix metalloproteinase-1] , -3 and -9 proteins on the chondrocytes in vitro . Positive_regulation MMP1 IL1B 11997239 939291 produced a dose dependent *increase* in [MMP] activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min . Positive_regulation MMP1 IL1B 12384923 999423 [MMP-1] and MMP-13 were expressed much higher in vitro than in vivo and were *up-regulated* by . Positive_regulation MMP1 IL1B 12412198 1010941 decreased the accumulation of aggrecan , hyaluronan and type II collagen in the CAM and *increased* intracellular [MMP-1] , -3 and -13 at a concentration of 100 pg/ml. Xylosan polysulphate and chrondroitin polysulphate restored the expression of these CAM molecules in these IL-1 beta treated cultures . Positive_regulation MMP1 IL1B 12428247 1014857 Ciprofloxacin also potentiated *stimulated* [MMP-1] mRNA expression , but did not potentiate the output of MMP-1 , and had no significant effects on MMP-2 mRNA expression or output . Positive_regulation MMP1 IL1B 12483727 1024847 Endogenous Bcl-3 expression was required for *induction* of [MMP-1] gene expression . Positive_regulation MMP1 IL1B 12483727 1024850 We showed previously that NF-kappaB1 contributes to *induction* of [MMP-1] transcription in stromal cells . Positive_regulation MMP1 IL1B 12568957 1057194 *induces* COX2 , [MMP-1] , -3 and -13 , ADAMTS-4 , IL-1 beta and IL-6 in human tendon cells . Positive_regulation MMP1 IL1B 12568957 1057196 also *stimulated* [MMP-1] and -3 protein secretion . Positive_regulation MMP1 IL1B 12784385 1096641 Treatment with HA ( 0.3 approximately 3.0 mg/ml ) resulted in a significant decrease in the production of [MMP-1] *induced* by TNF-a and , in a dose dependent manner . Positive_regulation MMP1 IL1B 12826666 1134612 Studies with specific inhibitors of MAPKs showed that p38 MAPK activation was necessary for both and [MMP-1] *induction* , but Erk activation was required only for MMP-1 induction . Positive_regulation MMP1 IL1B 12880581 1115753 Gene expressions of type I and II collagen , metalloproteinase-1 and -3 ( MMP-1 and -3 ) , and tissue inhibitor of metalloproteinase-1 ( TIMP-1 ) as well as the *induced* gene expressions of [MMP-1] and -3 were analyzed by reverse transcription-polymerase chain reaction ( RT-PCR ) . Positive_regulation MMP1 IL1B 12927975 1131933 [Pro-MMP-1] protein levels are unchanged with TNF-alpha and significantly *increased* with and IL-6 treatment . Positive_regulation MMP1 IL1B 14526152 1158388 In contrast , SB203580 ( p38 MAPK inhibitor ) , GF109203X ( PKC inhibitor ) , and PDTC ( NF-kappaB inhibitor ) did not alter the [MMP-1] secretion *induced* by and TNF-alpha . Positive_regulation MMP1 IL1B 14600251 1200291 Green tea polyphenol epigallocatechin-3-gallate ( EGCG ) differentially inhibits *induced* expression of [matrix metalloproteinase-1] and -13 in human chondrocytes . Positive_regulation MMP1 IL1B 14612199 1162858 Stimulation of cultured human aortic valve myofibroblasts with *lead* to a time-dependently increased expression of [MMP-1] and MMP-2 by Western blotting and zymography , whereas MMP-9 remained unchanged . Positive_regulation MMP1 IL1B 14638701 1171535 The *induced* expression of [MMP-1] , -2 , -3 , and -9 by corneal fibroblasts was inhibited by triptolide at the protein or mRNA level . Positive_regulation MMP1 IL1B 14722210 1197897 A biphasic E2 effect was also observed on *induced* disaggregation of PG , 53-58 kDa gelatinolytic activity , and [MMP-1] , -3 , and -13 mRNA levels . Positive_regulation MMP1 IL1B 14722210 1197898 Finally , simultaneous addition of IL1beta and E2 ( 0.1-10 nmol/l ) did not modify *induced* [MMP-1-luciferase] activity , suggesting that E2 effects probably occur at the post-transcriptional level of MMP gene expression . Positive_regulation MMP1 IL1B 14730602 1198945 However , Rb overexpression had no effect on spontaneous or *induced* production of IL-6 or [MMP-1] in non-RA synovial fibroblasts . Positive_regulation MMP1 IL1B 14872494 1208445 Preincubation with anti-CD44 antibody , which suppressed IL-1beta stimulated MMPs , reversed the inhibitory effect of HA on [MMP] production that was *induced* by in normal and OA cartilage . Positive_regulation MMP1 IL1B 14872494 1208462 This study demonstrates that HA effectively inhibits *stimulated* production of [MMP-1] , MMP-3 , and MMP-13 , which supports the clinical use of HA in the treatment of OA . Positive_regulation MMP1 IL1B 14974720 1212856 Both and tumor necrosis factor-alpha ( 10 ng/mL ) decreased fibrillin messenger RNA levels but *increased* [MMP-1] , -3 and -9 synthesis markedly . Positive_regulation MMP1 IL1B 14996278 1216211 *induces* [matrix metalloproteinase-1] expression in cultured human gingival fibroblasts : role of cyclooxygenase-2 and prostaglandin E2 . Positive_regulation MMP1 IL1B 14996278 1216213 We investigated the mechanism of MMP-1 expression in human gingival fibroblasts in *response* to the stimulation with , and the role of inducible-type cyclooxygenase-2 (COX-2) and prostaglandin E2 ( PGE2 ) in the regulation of [MMP-1] expression . Positive_regulation MMP1 IL1B 14996278 1216217 The effect of indomethacin , dexamethasone , or cycloheximide ( CHX ) on the *induced* expression of [MMP-1] was examined . Positive_regulation MMP1 IL1B 14996278 1216218 Pretreatment of the cells with indomethacin or dexamethasone inhibited the *induced* [MMP-1] expression . Positive_regulation MMP1 IL1B 14996278 1216222 The *induced* [MMP-1] expression in gingival fibroblasts may be mediated , at least in part , by COX-2 and its product PGE2 . Positive_regulation MMP1 IL1B 15094140 1238234 TNFalpha , IL-1alpha , and *led* to marked increases in [MMP-1] and MMP-3 release ( up to 4.2-fold and 547-fold , respectively ) by synovial fibroblasts , whereas secretion of MMP-13 was induced by concomitant administration of TNFalpha and IL-1beta . Positive_regulation MMP1 IL1B 15188355 1256656 The mean fold increases in A-SAA induced MMP-1 and MMP-3 production were 2.6 and 10.6 , respectively , compared with 7.6-fold and 41.9-fold increases in *induced* [MMP-1] and MMP-3 production . Positive_regulation MMP1 IL1B 15383690 1299068 Hyaluronate inhibits the *induced* expression of [matrix metalloproteinase (MMP)-1] and MMP-3 in human synovial cells . Positive_regulation MMP1 IL1B 15383690 1299072 Expression of [MMP-1] and MMP-3 mRNAs was *induced* by . Positive_regulation MMP1 IL1B 15383690 1299074 The mediated *induction* of [MMP-1] mRNA expression was attenuated by 10 microg/ml HA ( p=0.026 ) and that of MMP-3 mRNA was strongly down-regulated in the presence of 10 or 1000 microg/ml HA ( p < 0.001 ) . Positive_regulation MMP1 IL1B 15529381 1335750 [Matrix metalloprotease 1 (MMP-1)] and MMP-3 mRNA were *increased* by in normoxia and hypoxia , whereas only MMP-3 mRNA was enhanced in reoxygenated cultures . Positive_regulation MMP1 IL1B 15545168 1337810 [MMP-1] was *up-regulated* in Caco-2 cells by TGF-beta , EGF , and , but only by EGF in WiDR cells . Positive_regulation MMP1 IL1B 15652448 1364227 We comprehensively investigated the involvement of mitogen activated protein kinases ( MAPKs ) /activator protein-1 (AP-1) and IkappaB kinases ( IKKs ) /IkappaBs/nuclear factor-kappaB (NF-kappaB) in *stimulated* IL-6 , IL-8 , prostaglandin E ( 2 ) ( PGE ( 2 ) ) and [matrix metalloproteinase-1 (MMP-1)] production by human gingival fibroblasts (HGF) . Positive_regulation MMP1 IL1B 15979654 1459105 The expression of [MMP-1] , -2 , and -3 increased markedly in the *presence* of after day 21 of culture . Positive_regulation MMP1 IL1B 16140882 1450771 At the cellular level , PFE ( 6.25-25 mg/L ) inhibited the *induced* expression of [MMP-1] , -3 , and -13 protein in the medium ( P < 0.05 ) and this was associated with the inhibition of mRNA expression . Positive_regulation MMP1 IL1B 16206353 1464178 Pretreatment with 0.5 microM Se-met prevented *induced* [MMP-1] and aggrecanase-1 expression , and reduced the cytokine inhibitory effect on type II collagen , aggrecan core protein , and TGF-beta receptor II ( TGF-betaRII ) mRNA levels . Positive_regulation MMP1 IL1B 16273295 1479670 IL-1alpha and *promoted* [MMP-1] but not MMP-2 production in UVA irradiated fibroblasts . Positive_regulation MMP1 IL1B 16321971 1511606 In vitro , [MMP-1] is *up-regulated* by and tumor necrosis factor-alpha , but these regulatory mechanisms are not operating in H. pylori infection as shown by inhibitory antibodies . Positive_regulation MMP1 IL1B 16399619 1513036 In human primary chondrocytes , the production of [matrix metalloproteinase-13 and -1] ( MMP-13 and -1 ) and prostaglandin E2 ( PGE2 ) was *induced* by . Positive_regulation MMP1 IL1B 16449361 1573863 Production of [MMP-1] and MMP-3 by RSF was *stimulated* by . Positive_regulation MMP1 IL1B 16449361 1573870 HA at > or =2 mg/ml significantly inhibited [MMP] production *induced* by in a dose dependent manner . Positive_regulation MMP1 IL1B 16449361 1573892 Inhibition studies revealed the requirement of NF-kappaB , p38 and c-jun NH2-terminal kinase ( JNK ) for *induced* [MMP] production . Positive_regulation MMP1 IL1B 16453302 1540715 *induction* of [matrix metalloproteinase-1] transcription in chondrocytes requires ERK dependent activation of CCAAT enhancer binding protein-beta . Positive_regulation MMP1 IL1B 16453302 1540720 We further show that PD98059 reduces *induced* [MMP-1] mRNA expression in chondrocytes . Positive_regulation MMP1 IL1B 16459052 1534532 TAK1 downregulation reduces *induced* expression of MMP13 , [MMP1] and TNF-alpha . Positive_regulation MMP1 IL1B 16468044 1573934 Role of mitogen activated protein kinases and NFkappaB on *induced* effects on collagen type II , [MMP-1] and 13 mRNA expression in normal articular human chondrocytes . Positive_regulation MMP1 IL1B 16487663 1534911 *induced* [MMP-1] production by culture derived fibroblasts was determined with an MMP-1 immunoassay kit . Positive_regulation MMP1 IL1B 16522689 1567943 *stimulated* [MMP-1] ( 5.6-fold ) , MMP-2 ( 2.8-fold ) , and MMP-3 ( 75-fold ) gene expression , but not EMMPRIN , over levels in control cells ( P < 0.05 ) . Positive_regulation MMP1 IL1B 16549373 1582330 and TNFalpha strongly *induced* the expression of [MMP-1] and -13 in SW1353 cells and HACs , whereas only TNFalpha was found to induce the expression of these two MMPs in JJ012 cells . Positive_regulation MMP1 IL1B 16911716 1601754 Our results showed that *stimulated* [MMP-1] protein secretion and mRNA levels in a time dependent manner ( P < 0.05 ) , MMP-2 mRNA in a time dependent manner and MMP-3 in a time and dose dependent manner . Positive_regulation MMP1 IL1B 17009243 1634026 OSM potentiated *induced* [MMP-1] and MMP-13 expression in normal human cartilage/RASF cocultures , resulting in a significant increase in the MMP : TIMP ratio . Positive_regulation MMP1 IL1B 17097317 1709066 However , the roles of individual NF-kappaB family members during *induced* [MMP-1] gene expression have not been defined . Positive_regulation MMP1 IL1B 17097317 1709069 MMP-1 gene expression was mirrored by increases in NF-kappaB gene expression , and inhibition of NF-kappaB nuclear translocation with dominant negative IkappaBalpha reduced *dependent* [MMP-1] gene expression . Positive_regulation MMP1 IL1B 17097317 1709073 Small inhibitory RNAs ( siRNA ) specific for RelA resulted in significant reduction of MMP-1 mRNA , whereas siRNA for NF-kappaB1 and NF-kappaB2 augmented *induced* [MMP-1] expression . Positive_regulation MMP1 IL1B 17097317 1709074 Our data demonstrate that activation of the NF-kappaB pathway is *required* for IL-1beta induction of [MMP-1] in chondrocytes and that RelA can work independently of NF-kappaB1 or NF-kappaB2 to activate this gene expression program . Positive_regulation MMP1 IL1B 17283078 1710795 We demonstrate that PGE ( 2 ) represses *induced* [matrix metalloproteinase (MMP)-1] and that transient overexpression of NURR1 is sufficient to antagonize expression of this gene . Positive_regulation MMP1 IL1B 17328062 1711893 SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on *stimulated* [MMP] production and collagen degradation . Positive_regulation MMP1 IL1B 17599750 1774568 Cyclosporin A ( CSA ) , a Cn inhibitor , inhibited spontaneous and *stimulated* production of NO , [MMP-1] , and MMP-3 in chondrocytes . Positive_regulation MMP1 IL1B 17697361 1835022 *increased* the transcriptional and translational levels of [MMP-1] and MMP-13 in rheumatoid arthritis FLSs , whereas the levels of MMP-2 and MMP-9 were unaffected . Positive_regulation MMP1 IL1B 17876544 1796333 Both IL-17A and IL-17F augmented *induced* secretion of IL-6 , IL-8 , LIF , [MMP-1] , and MMP-3 . Positive_regulation MMP1 IL1B 17901089 1888863 No effect of CS was observed on *induced* gelatinolytic activity , [MMP1] mRNA expression or ADAMTS-4 expression . Positive_regulation MMP1 IL1B 17925024 1835233 These findings demonstrate , for the first time , that glucosamine inhibits *stimulated* [MMP] production in human chondrocytes by affecting MAPK phosphorylation . Positive_regulation MMP1 IL1B 17940116 1849319 We hypothesized that and TNF-alpha may *induce* [matrix metalloproteinase (MMP)-1] and MMP-3 activity to promote PTD by degrading decidual and fetal membranes and cervical extracellular matrix . Positive_regulation MMP1 IL1B 17940116 1849342 Compared with basal outputs by DCs incubated with E2 , TNF-alpha enhanced MMP-1 and MMP-3 secretion by 14 +/- 3- and 9 +/- 2-fold , respectively , and *increased* [MMP-1] and MMP-3 secretion by 13 +/- 3- and 19 +/- 2-fold , respectively ( P < 0.05 ) . Positive_regulation MMP1 IL1B 17940116 1849345 SB203580 suppressed TNF-alpha- and *induced* [MMP-1] and MMP-3 secretion by severalfold . Positive_regulation MMP1 IL1B 17996495 1894496 *increased* levels of [MMP-1] in peripheral blood monocytes of TB patients with 1G genotypes . Positive_regulation MMP1 IL1B 18060744 1846769 and macrophage migration inhibitory factor ( MIF ) in dermal fibroblasts *mediate* UVA induced [matrix metalloproteinase-1] expression . Positive_regulation MMP1 IL1B 18060744 1846771 *induced* [MMP-1] expression is inhibited by neutralizing anti-MIF antibody . Positive_regulation MMP1 IL1B 18060744 1846773 is involved in the up-regulation of UVA induced MMP-1 in dermal fibroblasts , and IL-1beta and MIF cytokine network *induce* [MMP-1] and contribute to the loss of interstitial collagen in skin photoaging . Positive_regulation MMP1 IL1B 18080123 1903344 Celecoxib at 100 nM reduced the *induced* productions of [MMP-1] , MMP-3 , iNOS , and NO , whereas indomethacin at 100 nM showed no effect . Positive_regulation MMP1 IL1B 18403593 1899525 DHA significantly decreased VSMC migration/proliferation *induced* by as well as [fibrinolytic/MMP] activity . Positive_regulation MMP1 IL1B 18427719 1920737 The present study clearly suggests that HA binds CD44 and inhibits *induced* [MMP-1] and -13 expression via down-regulation of Phos-p38 in SW-1353 cells . Positive_regulation MMP1 IL1B 18495175 1917416 In addition , Western blot analysis and gelatin zymography revealed that *activated* [matrix metalloproteinase (MMP)-1] and -3 in FLS . Positive_regulation MMP1 IL1B 18535174 1928792 *stimulated* [MMP] mRNA synthesis in wild-type , but not in IL-1RI-null cardiac fibroblasts . Positive_regulation MMP1 IL1B 18629644 2028055 Trichostatin A , a histone-deacetylase inhibitor , reduced *induced* [MMP-1] and MMP-3 mRNA expression , and suppressed TNF-alpha induced MMP-3 mRNA expression . Positive_regulation MMP1 IL1B 18676628 1979504 TPCA-1 inhibited the *induced* expression of [MMP-1] , -3 , and -9 in these cells at both the mRNA and protein levels and the IL-1beta induced activation of pro-MMP-2 . Positive_regulation MMP1 IL1B 18975308 1983136 To investigate the effects of prostaglandin D2 (PGD2) on *induced* [matrix metalloproteinase 1 (MMP-1)] and MMP-13 expression in human chondrocytes and the signaling pathways involved in these effects . Positive_regulation MMP1 IL1B 19046432 2006653 The goals of this study were to evaluate the inhibition of *induced* expression of [MMP-1] and MMP-13 by combinatorial treatment with RXR and PPARgamma ligands and to investigate the molecular mechanisms of this inhibition . Positive_regulation MMP1 IL1B 19046432 2006655 Combinatorial treatment activates each partner of the RXR : PPARgamma heterodimer and inhibits *induced* expression of [MMP-1] and MMP-13 more effectively than either compound alone . Positive_regulation MMP1 IL1B 19056796 2017693 Cordycepin inhibits *induced* [MMP-1] and MMP-3 expression in rheumatoid arthritis synovial fibroblasts . Positive_regulation MMP1 IL1B 19056796 2017695 In this study , we aimed at the inhibitory effect of cordycepin on *induced* [MMP-1] and MMP-3 expression as well as the molecular basis using RA synovial fibroblasts ( RASFs ) . Positive_regulation MMP1 IL1B 19056796 2017697 Cordycepin inhibited *induced* [MMP-1] and MMP-3 expressions in RASFs in a dose dependent manner . Positive_regulation MMP1 IL1B 19056796 2017709 Cordycepin is a potent inhibitor of *induced* chemokine production and [MMP] expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs . Positive_regulation MMP1 IL1B 19107653 2018860 Results showed that FGF2 and both *increased* [MMP-1] and -13 expression , while IL-1beta also increased MMP-3 mRNA levels . Positive_regulation MMP1 IL1B 19296842 2080047 The objective of this study was to evaluate the expression of 15-lipoxygenase-1 and -2 in human articular chondrocytes , and to investigate the effects of their metabolites 13 ( S ) -hydroxy octadecadienoic and 15 ( S ) -hydroxyeicosatetraenoic acids on *induced* [matrix metalloproteinase (MMP)-1] and MMP-13 expression . Positive_regulation MMP1 IL1B 19296842 2080049 13 ( S ) -hydroxy octadecadienoic and 15 ( S ) -hydroxyeicosatetraenoic acids dose dependently decreased *induced* [MMP-1] and MMP-13 protein and mRNA expression as well as type II collagen cleavage . Positive_regulation MMP1 IL1B 19296842 2080050 Their respective metabolites , namely 13 ( S ) -hydroxy octadecadienoic and 15 ( S ) -hydroxyeicosatetraenoic acids , suppressed *induced* [MMP-1] and MMP-13 expression in a PPARgamma dependent pathway . Positive_regulation MMP1 IL1B 19302792 2052087 [Matrix metalloproteinase-1] expression *induced* by requires acid sphingomyelinase . Positive_regulation MMP1 IL1B 19302792 2052088 The results suggest that *induced* expression of [MMP-1] is dependent on ASM . Positive_regulation MMP1 IL1B 19542681 2099192 *induced* [MMP] production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ) , p38 kinase , and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase (MAPK) family signal transduction molecules . Positive_regulation MMP1 IL1B 19602108 2247608 Effect of matrix metalloproteinase-1 promoter genotype on *induced* [matrix metalloproteinase-1] production in human periodontal ligament cells . Positive_regulation MMP1 IL1B 19602108 2247609 The purpose of this study was to evaluate the effect of different MMP-1 promoter genotypes on *induced* [MMP-1] production in human periodontal ligament cells . Positive_regulation MMP1 IL1B 19602108 2247610 The results of the present study suggest that the single nucleotide polymorphism at nucleotide -1607 of the human MMP-1 promoter might influence the *induced* expression of [MMP-1] in periodontal ligament cells . Positive_regulation MMP1 IL1B 19602123 2149831 significantly *up-regulated* the expression of [MMP-1] and MMP-2 mRNA and protein ( p < 0.05 ) ; however , the levels of mRNA and protein for extracellular MMP inducer were not significantly different ( p > 0.05 ) . Positive_regulation MMP1 IL1B 19602123 2149832 *up-regulated* the levels of [MMP-1] and MMP-2 , but it did not alter the expression of extracellular MMP inducer . Positive_regulation MMP1 IL1B 19787068 2141445 Inhibition of ASM completely abolished the *induction* of [MMP-1] by TNF or in Caco-2-IEC and human intestinal fibroblasts . Positive_regulation MMP1 IL1B 19787068 2141447 *Induction* of [MMP-1] by TNF or is completely blocked by inhibition of ASM with imipramine . Positive_regulation MMP1 IL1B 19910936 2272035 Post-fat load , circulating levels of WBC , [MMP-1] , and MMP-9 *increased* by 16 , 32 , and 43 % ( all P < 0.0001 ) , with no significant changes in . Positive_regulation MMP1 IL1B 19998410 2199762 The objective of this study was to investigate direct effects of PGE2 on *induced* [MMP-1] and MMP-13 expression and the intracellular signaling in articular chondrocytes . Positive_regulation MMP1 IL1B 19998410 2199764 PGE2 showed inhibitory effects on *induced* [MMP-1] and MMP-13 expression demonstrated by immunoblotting both in OA and normal chondrocytes , which was further confirmed by enzyme linked immunosorbent assay and immunohistochemistry of explant cultures of articular cartilages . Positive_regulation MMP1 IL1B 19998410 2199766 These results demonstrate that PGE2 inhibits *induced* [MMP-1] and MMP-13 productions via EP4 by suppressing MKK4-JNK MAP kinase-c-JUN pathway . Positive_regulation MMP1 IL1B 20403707 2282280 *induced* [MMP] production was significantly augmented in the presence of sIL-6R . Positive_regulation MMP1 IL1B 20471972 2288522 Inhibitory effects of baicalin on *induced* [MMP-1/TIMP-1] and its stimulated effect on collagen-I production in human periodontal ligament cells . Positive_regulation MMP1 IL1B 20471972 2288524 The present study suggests that baicalin inhibits *induction* of [MMP-1] by altering the mRNA and protein levels . Positive_regulation MMP1 IL1B 21344389 2480421 IL-1B treatment increased CEBPB expression in SW1353 cells over a 24-h period and knockdown of CEBPB with shRNA abrogated *dependent* [MMP-1] and MMP-13 gene activation . Positive_regulation MMP1 IL1B 21344389 2480423 Exogenous expression of the CEBPB isoforms LAP1 or LAP2 was sufficient to induce MMP-1 mRNA levels comparable to IL-1B induced expression , while the truncated LIP isoform repressed *induced* [MMP-1] . Positive_regulation MMP1 IL1B 21344389 2480424 We found that the MEK inhibitor U0126 and the RSK inhibitor BI-D1870 both reduced *dependent* [MMP-1] gene expression in SW1353 cells . Positive_regulation MMP1 IL1B 21344389 2480436 These findings establish CEBPB as a critical intermediate for dependent [MMP] gene *activation* and assign specific roles for the ERK and RSK kinases in this pathway . Positive_regulation MMP1 IL1B 22792188 2628377 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation MMP1 IL1B 8208667 261612 The levels of active [interstitial collagenase] produced by BeWo cells were *increased* by ( 100-1000 pg/ml ) , which paralleled the decrease in cell growth . Positive_regulation MMP1 IL1B 8594877 342044 *induces* [interstitial collagenase] gene expression and protein secretion in renal mesangial cells . Positive_regulation MMP1 IL1B 8594877 342045 These data suggest that *stimulates* [interstitial collagenase] synthesis and activation and that a tyrosine kinase pathway is involved in the signal transduction mechanisms and is not dependent on endogenous prostaglandin biosynthesis . Positive_regulation MMP1 IL1B 9269785 450129 Whereas [MMP-1] is positively *regulated* by , tumor necrosis factor-alpha , and Oncostatin M , MMP-2 is not modulated by any of these cytokines . Positive_regulation MMP1 IL1B 9558121 500080 Recombinant TNF-alpha and added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP1 IL1B 9738019 531818 Serotonin mediated production of [interstitial collagenase] by uterine smooth muscle cells *requires* interleukin-1alpha , but not . Positive_regulation MMP1 IL1B 9821179 548114 The inflammatory cytokine did not *induce* [MMP] or TIMP expression . Positive_regulation MMP1 IL1B 9890433 585411 A beta , but not or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells , as well as *increased* the expression of the well-known activator of MMP-2 , membrane-type ( MT ) [-MMP] . Positive_regulation MMP1 IL1B 9933437 589384 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by and TNF-alpha or down-regulated by IFN-gamma . Positive_regulation MMP1 IL6R 12146533 969822 The *role* of soluble in mediating the effects of IL-6 on [matrix metalloproteinase-1] and tissue inhibitor of metalloproteinase-1 expression by gingival fibroblasts . Positive_regulation MMP1 MAP2K6 11179516 784794 EGF receptor kinase inhibitor PD153035 and AG1478 and inhibitor PD98059 also *blocked* IL-1 beta induction of [MMP-1] in cultured human keratinocytes . Positive_regulation MMP1 MAP2K6 12060661 975665 Activation of endogenous or adenovirally expressed p38 alpha by adenovirally delivered constitutively active MKK3b and also *enhanced* [MMP-1] and MMP-3 expression and augmented the up-regulatory effect of ERK1/2 activation on the expression of these MMPs . Positive_regulation MMP1 MAP2K6 17475625 1761401 inhibitors UO126 and PD98059 *inhibited* both CagA independent and -dependent [MMP-1] secretion , whereas p38 inhibition enhanced MMP-1 secretion and ERK activation , suggesting p38 negative regulation of MMP-1 and ERK . Positive_regulation MMP1 MAP2K6 19833163 2196097 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP1 MAP2K6 20545600 2308391 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP1 MAP2K6 21440529 2417063 The specific inhibitor , U0126 , significantly *blocks* EGF and TGF-a mediated ERK1/2 activation and subsequent [MMP1] induction in SK-BR3 cells . Positive_regulation MMP1 MAP2K6 22310287 2718925 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP1 MATN2 19840795 2165261 stimulation *leads* to the induction of [MMP1] , MMP3 , MMP13 , COX-2 , iNOS , IL-1beta , TNFalpha , IL-6 and IL-8 . Positive_regulation MMP1 MMP7 2174435 145677 [mmp-1] transcription was *increased* by greater than 25-fold , mmp-2 by approximately 3-fold , and by approximately 7-fold . Positive_regulation MMP1 PLAU 17709546 1783168 , which does not , significantly *enhanced* [MMP-1] synthesis by activated human monocytes . Positive_regulation MMP1 PODXL 17616675 1769328 These findings suggest that leads to increased in vitro migration and invasion , *increased* [MMP] expression , and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MMP1 SPHK1 16278291 1502525 In this study , we investigated the *role* of in the regulation of expression of [matrix metalloproteinase 1 (MMP1)] in dermal fibroblasts , a key event in regulation of extra cellular matrix . Positive_regulation MMP1 SPHK1 16278291 1502529 Furthermore , experiments using SphK1 specific siRNA demonstrated that is *required* for the TNF-alpha stimulation of [MMP1] . Positive_regulation MMP1 SPHK1 16278291 1502531 Additional data revealed a specific role of dhS1P , and not S1P , as a mediator of *dependent* activation of ERK1/2 and up-regulation of [MMP1] . Positive_regulation MMP1 TFPI2 10082661 599114 Collectively , our results suggest that indirectly *regulates* [MMP-1-] and MMP-3 catalyzed matrix proteolysis by regulating the activation of proMMP-1 and proMMP-3 . Positive_regulation MMP1 TFPI2 12787920 1097088 These data provide presumptive evidence that does not bind to MMP-2 , MMP-9 and MMP-1 , or *regulate* [MMP-1] , in the extracellular matrix . Positive_regulation MMP1 TGM2 24130925 2714718 Gene silencing of *suppressed* the [MMP] expression by ATRA . Positive_regulation MMP1 TLR7 18802113 1964686 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP1 TNF 10362800 620152 *induced* cathepsin S , [MMP-1] , -3 , and -9 mRNA expression in a dose dependent manner : the maximal effect was observed at a concentration of 10 ng/ml , with appreciable increases observed at concentrations of 0.1 to 1.0 ng/ml . Positive_regulation MMP1 TNF 10482270 643774 We also examined the possibility that such MMPs could be produced by brain derived cells , and that [MMP] production by these cells might be *increased* by , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD . Positive_regulation MMP1 TNF 10645003 661755 IFN-gamma abolished the *enhancement* of MMP-13 and [MMP-1] expression by transforming growth factor-beta ( TGF-beta ) and , and inhibited invasion of A-5 cells through type I collagen . Positive_regulation MMP1 TNF 10864917 705826 IL-1beta and each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP1 TNF 11147175 760920 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that may *induce* [MMP] production followed by matrix degradation within foreign body granulomas . Positive_regulation MMP1 TNF 11450703 836646 Furthermore , the inhibitors completely prevented the *dependent* induction of [MMP-1] , MMP-3 , ICAM-1 , and COX-2 mRNAs . Positive_regulation MMP1 TNF 11487149 845175 *Induction* of dental pulp fibroblast [matrix metalloproteinase-1] and tissue inhibitor of metalloproteinase-1 gene expression by interleukin-1alpha and through a prostaglandin dependent pathway . Positive_regulation MMP1 TNF 11487149 845180 Northern hybridization showed that IL-1alpha and *induced* significant [MMP-1] gene expression , with only little effect on TIMP-1 gene . Positive_regulation MMP1 TNF 11487149 845182 The differential regulation of IL-1alpha or *induced* [MMP-1] and TIMP-1 mRNA synthesis , as well as the direct upregulation of TIMP-1 gene expression by PGE2 , also implied that prostaglandin may serve as a protective mechanism from excessive tissue breakdown during pulpitis . Positive_regulation MMP1 TNF 11773040 899397 Isolated RMVECs did not significantly increase [MMP] production directly in response to a hypoxic stimulus , but *required* the presence of exogenous . Positive_regulation MMP1 TNF 11916194 925459 IL-1beta and both *induced* a dose- and time dependent increase in IL-8 , MCP-1 and [MMP-1] secretion , and weakly stimulated MMP-2 secretion . Positive_regulation MMP1 TNF 12010565 941223 Of these enzymes , the expression of [MMP-1] and MMP-13 is substantially increased in *response* to IL-1 and , and elevated levels of these collagenases are observed in arthritic tissues . Positive_regulation MMP1 TNF 12050187 950390 In contrast , HDL suppressed the *induction* of [MMP-1] by and GM-CSF as well as the ox-LDL mediated increase in MMP-1 production . Positive_regulation MMP1 TNF 12113550 963861 Because elevation of COX-2 mRNA levels enhances the production of prostaglandins , we therefore investigated whether endogenous prostaglandins are involved in the [MMP] mRNA expression that is *enhanced* by . Positive_regulation MMP1 TNF 12147614 970032 TGF-beta(2) , IL-1beta , and *enhanced* secretion of [MMP-1] , -2 , and -3 . Positive_regulation MMP1 TNF 12147614 970038 The mRNA levels of [MMP-1] , -2 , and -3 and TIMP-1 were markedly *increased* by and TGF-beta(2) . Positive_regulation MMP1 TNF 12206592 983452 In addition , [MMP-1] and MMP-3 production , *induced* by IL-1beta , or EGF , was strongly reduced by the presence of the glucocorticoid dexamethasone . Positive_regulation MMP1 TNF 12506073 1038359 Both IL-4 and -13 significantly decreased production of MMP-1 and increased that of TIMP-1 , whereas *increased* production of [MMP-1] and -9 . Positive_regulation MMP1 TNF 12510804 1038799 Interestingly , SNAP , a NO donor , although by itself is not a MMP-1 stimulator for UMR-106 , augmented the *stimulated* [MMP-1] mRNA production in UMR-106 . Positive_regulation MMP1 TNF 12606436 1064563 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP1 TNF 12784385 1096640 Treatment with HA ( 0.3 approximately 3.0 mg/ml ) resulted in a significant decrease in the production of [MMP-1] *induced* by and IL-1beta , in a dose dependent manner . Positive_regulation MMP1 TNF 12909329 1121945 *mediates* the stretch induced [MMP] genes expression , at least in part , through the JNK pathway . Positive_regulation MMP1 TNF 12913922 1129687 stimulation *induced* IL-6 secretion by RA SFB ( 3-fold ) and OA SFB ( 4-fold ) , as well as [MMP-1] secretion ( RA , 85-fold ; Positive_regulation MMP1 TNF 12960156 1158183 and granulocyte macrophage colony stimulating factor ( GM-CSF ) individually enhance monocyte matrix metalloproteinase-9 (MMP-9) but *induce* [MMP-1] only when added in combination . Positive_regulation MMP1 TNF 14526152 1158385 IL-1l and *stimulated* the [MMP-1] secretion in a dose- and time dependent manner . Positive_regulation MMP1 TNF 14526152 1158387 In contrast , SB203580 ( p38 MAPK inhibitor ) , GF109203X ( PKC inhibitor ) , and PDTC ( NF-kappaB inhibitor ) did not alter the [MMP-1] secretion *induced* by IL-1beta and . Positive_regulation MMP1 TNF 14673992 1178622 The in vivo data clearly indicated that OSM + overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP1 TNF 14974720 1212855 Both interleukin-1beta and ( 10 ng/mL ) decreased fibrillin messenger RNA levels but *increased* [MMP-1] , -3 and -9 synthesis markedly . Positive_regulation MMP1 TNF 15044327 1272755 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to dependent [MMP] *induction* in the macrophages . Positive_regulation MMP1 TNF 15094140 1238232 , IL-1alpha , and IL-1beta *led* to marked increases in [MMP-1] and MMP-3 release ( up to 4.2-fold and 547-fold , respectively ) by synovial fibroblasts , whereas secretion of MMP-13 was induced by concomitant administration of TNFalpha and IL-1beta . Positive_regulation MMP1 TNF 15146414 1247776 RzMMP-1 not only reduced the spontaneous production of MMP-1 , but also prevented the LPS- and *induced* increase in [MMP-1] production . Positive_regulation MMP1 TNF 15183075 1255924 These results suggest that PDE4 inhibitors are effective in inhibiting the pro-MMP-2 and [pro-MMP-1] secretion *induced* by and might underline a potential therapeutic benefit of selective PDE4 inhibitors in lung diseases associated with abnormal tissue remodelling . Positive_regulation MMP1 TNF 15184206 1280571 *causes* increased [MMP] production , but some increased MMP activity is present even in TNFRKO mice . Positive_regulation MMP1 TNF 15201935 1260846 IL-1 and are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP1 TNF 15930517 1433902 We also found that EPA inhibited 12-O-tetradecanoylphorbol-13-acetate- or *induced* [MMP-1] expression in HDFs and UV-induced MMP-1 expression in HaCaT cells . Positive_regulation MMP1 TNF 15946654 1421012 We showed that both [MMP-1] and MMP-13 mRNA expression , protein production and enzyme activity *induced* by either IL-1 or were suppressed by t-RA or different retinoid derivatives . Positive_regulation MMP1 TNF 16012040 1431588 stimulated MMP-9 secretion in both cell lines , but only *stimulated* [MMP-1] secretion in one ( UT-SCC-24A ) . Positive_regulation MMP1 TNF 16321971 1511605 In vitro , [MMP-1] is *up-regulated* by interleukin-1beta and , but these regulatory mechanisms are not operating in H. pylori infection as shown by inhibitory antibodies . Positive_regulation MMP1 TNF 16519794 1574359 Silencing of NFkappaB1 by small interfering RNA abrogated the capacity of RA bone marrow CD34+ cells to differentiate into fibroblast-like cells and to produce [MMP-1] and vascular endothelial growth factor upon *stimulation* with stem cell factor , granulocyte-macrophage colony stimulating factor and without influencing their viability and capacity to produce beta2-microglobulin . Positive_regulation MMP1 TNF 16549372 1582236 and OSM induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP1 TNF 16549373 1582329 IL-1beta and strongly *induced* the expression of [MMP-1] and -13 in SW1353 cells and HACs , whereas only TNFalpha was found to induce the expression of these two MMPs in JJ012 cells . Positive_regulation MMP1 TNF 16911716 1601755 stimulated MMP-1 and -3 protein secretion in a time dependent manner and *stimulated* [MMP-1] , -2 and -3 mRNA levels in a time dependent manner ( P < 0.05 ) . Positive_regulation MMP1 TNF 16959273 1646609 Emodin inhibits *induced* [MMP-1] expression through suppression of activator protein-1 (AP-1) . Positive_regulation MMP1 TNF 16959273 1646610 In this study , we found that emodin , an anthraquinone which has been isolated from the rhizome of Rheum palmatum , significantly inhibited *induced* [MMP-1] gene expression in a concentration dependent manner . Positive_regulation MMP1 TNF 16959273 1646611 Therefore , we have attempted to characterize the inhibitory mechanism of emodin in *induced* [MMP-1] expression . Positive_regulation MMP1 TNF 16959273 1646613 In a consistent result , the *induced* [MMP-1] expression was inhibited by PD98059 ( MEK/ERK inhibitor ) and SP600125 ( JNK inhibitor ) , but was not inhibited by SB203580 , a p38 MAPK inhibitor . Positive_regulation MMP1 TNF 16959273 1646614 Taken together , these results show that emodin suppresses *induced* [MMP-1] expression through the inhibition of the AP-1 signaling pathway . Positive_regulation MMP1 TNF 17031853 1683037 Prostaglandin E2 downregulates *induced* production of [matrix metalloproteinase-1] in HCS-2/8 chondrocytes by inhibiting Raf-1/MEK/ERK cascade through EP4 prostanoid receptor activation . Positive_regulation MMP1 TNF 17031853 1683038 In *response* to , [MMP-1] is induced and actively released from HCS-2/8 cells . Positive_regulation MMP1 TNF 17031853 1683054 In contrast , SB203580 , a selective p38 mitogen activated protein kinases (MAPK) inhibitor , had no effects on *induced* [MMP-1] release . Positive_regulation MMP1 TNF 17031853 1683071 In contrast , blockade of endogenously produced PGE ( 2 ) signaling by ONO-AE3-208 , a selective EP4 receptor antagonist , enhanced *induced* [MMP-1] production . Positive_regulation MMP1 TNF 17031853 1683075 Taken together , these findings indicate that Raf-1/MEK/ERK signaling pathway plays a crucial role in the production of [MMP-1] in HCS-2/8 cells in *response* to , and that the produced PGE ( 2 ) downregulates the expression of MMP-1 by blockage of TNF-alpha induced Raf-1 activation through EP4-PGE ( 2 ) receptor activation . Positive_regulation MMP1 TNF 17062332 1637221 To investigate the regulatory effects of fenofibrate on *induced* CD40 expression and [matrix metalloproteinase (MMP)] activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation MMP1 TNF 17214640 1681788 Roxithromycin inhibits *induced* [matrix metalloproteinase-1] expression through regulating mitogen activated protein kinase phosphorylation and Ets-1 expression . Positive_regulation MMP1 TNF 17214640 1681790 In the present study , we examined the effect of roxithromycin on *induced* [MMP-1] production by HPDL cells . Positive_regulation MMP1 TNF 17214640 1681791 In HPDL cell cultures , roxithromycin strongly inhibited *induced* [MMP-1] mRNA expression and production . Positive_regulation MMP1 TNF 17214640 1681835 Roxithromycin inhibits mediated [MMP-1] *induction* through the downregulation of ERK1/2 and JNK activation and the subsequent reduction of Ets-1 , suggesting that roxithromycin may have therapeutic use in periodontitis and other chronic inflammatory conditions involving MMP-1 induction . Positive_regulation MMP1 TNF 17223661 1765552 The above effects were comparable in RA- and OA-SFB , except that *induced* [MMP-1] secretion was reversed by p38 inhibition only in OA-SFB . Positive_regulation MMP1 TNF 17469134 1737512 OSM and *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP1 TNF 17507431 1791855 Moreover , [MMP] activity in PCPEC supernatants was significantly *increased* by , presumably due to a diminished expression of TIMP-3 that was similarly observed . Positive_regulation MMP1 TNF 17876544 1796342 A similar augmentation was also observed in *induced* cytokine and [MMP] secretion . Positive_regulation MMP1 TNF 17940116 1849318 We hypothesized that IL-1beta and may *induce* [matrix metalloproteinase (MMP)-1] and MMP-3 activity to promote PTD by degrading decidual and fetal membranes and cervical extracellular matrix . Positive_regulation MMP1 TNF 17940116 1849341 Compared with basal outputs by DCs incubated with E2 , enhanced MMP-1 and MMP-3 secretion by 14 +/- 3- and 9 +/- 2-fold , respectively , and IL-1beta *increased* [MMP-1] and MMP-3 secretion by 13 +/- 3- and 19 +/- 2-fold , respectively ( P < 0.05 ) . Positive_regulation MMP1 TNF 18053242 1836235 LPS and *induced* collagen1 and fibronectin levels as well as the matrix degradation enzyme [MMP-1] . Positive_regulation MMP1 TNF 18212480 1857919 Mellitin had no effect on IL-1beta- or *induced* [MMP1] or MMP3 production and did not decrease LPS induced secretion of MMP1 . Positive_regulation MMP1 TNF 18496696 1965697 Here we show that epigallocatechin-3-Gallate ( EGCG ) suppresses *induced* production of [MMP-1] and MMP-3 in RA synovial fibroblasts , which was accompanied by inhibition of mitogen activated protein kinase (MAPK) and activator protein-1 (AP-1) pathways . Positive_regulation MMP1 TNF 18496696 1965699 EGCG treatment resulted in dose dependent inhibition of *induced* production of [MMP-1] and MMP-3 at the protein and mRNA levels in RA synovial fibroblast . Positive_regulation MMP1 TNF 18629644 2028053 Propionate and butyrate significantly attenuated IL-1 beta- and *induced* [MMP-1] and MMP-3 secretion . Positive_regulation MMP1 TNF 18684973 1949190 Down-regulation of annexin-1 using small interfering RNA resulted in decreased secretion of both annexin-1 and MMP-1 , confirming that annexin-1 mediates *stimulated* [MMP-1] secretion . Positive_regulation MMP1 TNF 19026560 2001506 suppressed collagen type II and aggrecan , but *increased* [MMP] and cytokine expression in chondrocytes compared to the non stimulated controls . Positive_regulation MMP1 TNF 19055644 1999852 This study explored the transcriptional *induction* of the [MMP-1] gene by in HSCs . Positive_regulation MMP1 TNF 19055644 1999856 [MMP-1] gene expression might be *induced* by via the p50/p50 homodimer of NF-kappaB in activated human HSCs . Positive_regulation MMP1 TNF 19435506 2106969 does not *induce* [MMP] expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation MMP1 TNF 19531758 2116225 On the other hand , knockdown of HDAC1 , but not of HDAC2 , upregulated *induced* [MMP-1] production by RA-SF . Positive_regulation MMP1 TNF 19542367 2103688 In contrast , *induced* [MMP-1] secretion was not influenced by NS-398 and diminished by PGE ( 2 ) via EP2 . Positive_regulation MMP1 TNF 19542367 2103690 In conclusion , PGE ( 2 ) differentially affects *induced* mRNA expression of proinflammatory IL-6 and prodestructive [MMP-1] regarding the usage of EP receptors and the dependency on cAMP . Positive_regulation MMP1 TNF 19661147 2150527 In stromal cultures derived from control women and those with endometriosis , *augmented* the intracellular proMMP1 ( 1.2-fold in control stromal cells ) and ICAM1 ( 1.4- and 1.9-fold ) , greatly increased [MMP1] and proMMP9 levels , and the sICAM1 concentration ( 2.3- and 4.3-fold ) in their media compared with basal levels . Positive_regulation MMP1 TNF 19787068 2141444 Inhibition of ASM completely abolished the *induction* of [MMP-1] by or IL-1beta in Caco-2-IEC and human intestinal fibroblasts . Positive_regulation MMP1 TNF 19787068 2141446 *Induction* of [MMP-1] by or IL-1beta is completely blocked by inhibition of ASM with imipramine . Positive_regulation MMP1 TNF 19909407 2258397 In contrast , significantly *increased* [MMP-1] expression , and EMD reduced it when both agents were present . Positive_regulation MMP1 TNF 20007453 2210584 We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since *induced* superoxide production , [MMP] expression , and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma . Positive_regulation MMP1 TNF 20357815 2287674 Here , we investigated the effect of cAMP on *induced* [MMP-1] expression and the molecular events involved in the processes in human skin fibroblasts . Positive_regulation MMP1 TNF 20357815 2287675 We showed that cAMP suppresses *induced* [MMP-1] expression via protein kinase A (PKA) pathway . Positive_regulation MMP1 TNF 20403361 2267423 While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha , however , [matrix metalloproteinase (MMP)] *activation* of may also be contributory . Positive_regulation MMP1 TNF 21550856 2464028 RA BM pDC as well as OA BM pDC comparably differentiated into fibroblast-like cells ( FLC ) , expressing cadherin-11 and producing [MMP-1] , especially in the *presence* of . Positive_regulation MMP1 TNF 22922824 2672506 with and without trauma significantly *induced* [MMP1] gene expression . Positive_regulation MMP1 TNF 23300643 2712404 Fibroblasts from intestinal muscle expressed Ra1 , phosphorylated STAT6 in response to IL-13 , and subsequently down-regulated MMP-2 and *induced* [MMP-1] and MMP-9 synthesis . Positive_regulation MMP1 TNF 23370854 2818512 We here investigated the effect of CK ( 0-5 µM ) on *induced* [MMP-1] , MMP-3 , and MMP-13 and TIMP-1 production from RA fibroblast-like synoviocytes ( FLS ) and determined the inhibitory effect of CK on osteoclastogenesis from RAW264.7 cells co-cultured with RA-FLS and from human CD14+ monocytes . Positive_regulation MMP1 TNF 23417988 2843302 SUMO-2/3 was knocked down using small interfering RNA in SFs , and *induced* [MMP] production was determined by ELISA . Positive_regulation MMP1 TNF 23417988 2843335 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by TNF-a and selectively control *mediated* [MMP] expression via the NF-?B pathway . Positive_regulation MMP1 TNF 23603294 2795170 The expression of [MMP-1] , MMP-3 , and MMP-9 increased in the *presence* of , and the addition of infliximab reversed the increase . Positive_regulation MMP1 TNF 23603294 2795178 Furthermore , infliximab effectively attenuated the *induced* increases in [MMP] expression in cells that make up the BAB . Positive_regulation MMP1 TNF 7543547 314339 Northern hybridization assays showed pretranslational control of PMA- , basic fibroblast growth factor- , and *induced* [MMP] expression . Positive_regulation MMP1 TNF 7558248 327964 *enhances* [MMP-1] transcription nearly 12-fold initially , after which mRNA levels drop off but remain significantly higher than the controls . Positive_regulation MMP1 TNF 8045973 266922 Both interleukin-1 alpha and *stimulated* the secretion of [MMP-1] , MMP-3 , and MMP-9 , but not MMP-2 , from the cells in a concentration dependent manner . Positive_regulation MMP1 TNF 9014820 405409 In support of this result , stimulation *induced* membrane-type matrix metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation MMP1 TNF 9497391 490531 Small strains did not induce MMP-1 in VSMCs , but strain was a potent inhibitor of platelet derived growth factor ( PDGF ) - or *induced* synthesis of [MMP-1] . Positive_regulation MMP1 TNF 9536233 497479 *increased* the mRNA expression of [matrix metalloproteinase-1] and tissue inhibitor of metalloproteinase-1 both in monolayer and three-dimensional culture . Positive_regulation MMP1 TNF 9543636 498193 A phorbol mitogen ( TPA ) , and and beta , interleukin-1 alpha and PDGF BB *stimulate* gelatinase B , stromelysin , [interstitial collagenase] and TIMP-1 expression , while having negligible effects on gelatinase A expression ; Positive_regulation MMP1 TNF 9558121 500079 Recombinant and IL-1beta added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP1 TNF 9614183 509481 alone did not *induce* [interstitial collagenase] expression in rat lung fibroblasts but did in rat skin fibroblasts , revealing tissue specificity in the regulation of this gene . Positive_regulation MMP1 TNF 9631748 512561 *increased* the total [MMP] activity released . Positive_regulation MMP1 TNF 9927150 588410 In general , *stimulated* both [MMP] and TIMP expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation MMP1 TNF 9933437 589383 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by IL-1beta and or down-regulated by IFN-gamma . Positive_regulation MMP10 CAPN8 21911754 2496936 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP10 CAPN8 21964156 2525714 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP10 CAPN8 22316244 2553220 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP10 CTGF 18632843 1979311 In conclusion , upregulation of inhibits BMP-7 signal transduction in the diabetic kidney and *contributes* to altered gene transcription , reduced [MMP] activity , glomerular basement membrane thickening , and albuminuria , all of which are hallmarks of diabetic nephropathy . Positive_regulation MMP10 EPHB2 14709335 1196638 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP10 EPHB2 19221016 2050240 ACh induced MMP1 , MMP7 , and [MMP10] gene transcription was *attenuated* by atropine , anti-EGFR antibody , and chemical inhibitors of EGFR and activation . Positive_regulation MMP10 EPHB2 20843518 2353060 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and *dependent* [MMP] expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation MMP10 EPHB2 22142512 2536333 In conclusion , we demonstrated that CRP promoted MMP-10 expression and activity in cardiomyocytes , and clarified that c-Raf/MEK/ERK and signaling pathways were *involved* in [MMP-10] expression regulation via activation of DNA binding sites for AP-1 and STAT3 in cardiomyocytes . Positive_regulation MMP10 EPHB2 24012928 2862347 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an [MMP] *inhibitor* , or PD98059 ( 50 µM ) , an inhibitor , also suppressed it . Positive_regulation MMP10 IGFBP1 15590975 1346149 Cell numbers were increased only by 100 nM IGFBP-1 isoforms ( P < 0.05 ) , whereas [MMP] levels released from term cells were optimally *increased* by 1-10 nM . Positive_regulation MMP10 IL1B 10727770 678119 and TPA alone *induced* [MMP] activity in HIG-82 cells . Positive_regulation MMP10 IL1B 10864917 705829 and TNF-alpha each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP10 IL1B 10895370 711602 In support of this result , stimulation *induced* the expression of membrane type matrix-metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation MMP10 IL1B 11327259 807566 A decrease in IL-1alpha , , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP10 IL1B 11467889 840793 In all cases , PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on *induction* of [MMP] expression . Positive_regulation MMP10 IL1B 11997239 939292 produced a dose dependent *increase* in [MMP] activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min . Positive_regulation MMP10 IL1B 14872494 1208446 Preincubation with anti-CD44 antibody , which suppressed IL-1beta stimulated MMPs , reversed the inhibitory effect of HA on [MMP] production that was *induced* by in normal and OA cartilage . Positive_regulation MMP10 IL1B 16449361 1573871 HA at > or =2 mg/ml significantly inhibited [MMP] production *induced* by in a dose dependent manner . Positive_regulation MMP10 IL1B 16449361 1573893 Inhibition studies revealed the requirement of NF-kappaB , p38 and c-jun NH2-terminal kinase ( JNK ) for *induced* [MMP] production . Positive_regulation MMP10 IL1B 17328062 1711894 SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on *stimulated* [MMP] production and collagen degradation . Positive_regulation MMP10 IL1B 17925024 1835247 These findings demonstrate , for the first time , that glucosamine inhibits *stimulated* [MMP] production in human chondrocytes by affecting MAPK phosphorylation . Positive_regulation MMP10 IL1B 18403593 1899526 DHA significantly decreased VSMC migration/proliferation *induced* by as well as [fibrinolytic/MMP] activity . Positive_regulation MMP10 IL1B 18535174 1928793 *stimulated* [MMP] mRNA synthesis in wild-type , but not in IL-1RI-null cardiac fibroblasts . Positive_regulation MMP10 IL1B 19056796 2017710 Cordycepin is a potent inhibitor of *induced* chemokine production and [MMP] expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs . Positive_regulation MMP10 IL1B 19542681 2099193 *induced* [MMP] production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ) , p38 kinase , and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase (MAPK) family signal transduction molecules . Positive_regulation MMP10 IL1B 20403707 2282281 *induced* [MMP] production was significantly augmented in the presence of sIL-6R . Positive_regulation MMP10 IL1B 21344389 2480437 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Positive_regulation MMP10 IL1B 22792188 2628378 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation MMP10 IL1B 9558121 500082 Recombinant TNF-alpha and added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP10 IL1B 9821179 548115 The inflammatory cytokine did not *induce* [MMP] or TIMP expression . Positive_regulation MMP10 IL1B 9890433 585412 A beta , but not or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells , as well as *increased* the expression of the well-known activator of MMP-2 , membrane-type ( MT ) [-MMP] . Positive_regulation MMP10 IL1B 9933437 589386 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by and TNF-alpha or down-regulated by IFN-gamma . Positive_regulation MMP10 MAP2K6 19833163 2196104 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP10 MAP2K6 20545600 2308398 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP10 MAP2K6 22142512 2536340 In conclusion , we demonstrated that CRP promoted MMP-10 expression and activity in cardiomyocytes , and clarified that and JAK1/ERK signaling pathways were *involved* in [MMP-10] expression regulation via activation of DNA binding sites for AP-1 and STAT3 in cardiomyocytes . Positive_regulation MMP10 MAP2K6 22310287 2718932 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP10 PODXL 17616675 1769329 These findings suggest that leads to increased in vitro migration and invasion , *increased* [MMP] expression , and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MMP10 TGM2 24130925 2714719 Gene silencing of *suppressed* the [MMP] expression by ATRA . Positive_regulation MMP10 TLR7 18802113 1964696 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP10 TNF 10482270 643775 We also examined the possibility that such MMPs could be produced by brain derived cells , and that [MMP] production by these cells might be *increased* by , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD . Positive_regulation MMP10 TNF 10864917 705828 IL-1beta and each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP10 TNF 11069614 747839 In keratinocyte cultures , , epidermal growth factor , and transforming growth factor-beta1 *induced* [stromelysin-2] expression as measured by quantitative reverse transcriptase-polymerase chain reaction , whereas different matrices did not upregulate the mRNA . Positive_regulation MMP10 TNF 11147175 760921 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that may *induce* [MMP] production followed by matrix degradation within foreign body granulomas . Positive_regulation MMP10 TNF 11773040 899398 Isolated RMVECs did not significantly increase [MMP] production directly in response to a hypoxic stimulus , but *required* the presence of exogenous . Positive_regulation MMP10 TNF 12113550 963862 Because elevation of COX-2 mRNA levels enhances the production of prostaglandins , we therefore investigated whether endogenous prostaglandins are involved in the [MMP] mRNA expression that is *enhanced* by . Positive_regulation MMP10 TNF 12606436 1064565 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP10 TNF 12909329 1121946 *mediates* the stretch induced [MMP] genes expression , at least in part , through the JNK pathway . Positive_regulation MMP10 TNF 14673992 1178624 The in vivo data clearly indicated that OSM + overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP10 TNF 15044327 1272756 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to dependent [MMP] *induction* in the macrophages . Positive_regulation MMP10 TNF 15184206 1280572 *causes* increased [MMP] production , but some increased MMP activity is present even in TNFRKO mice . Positive_regulation MMP10 TNF 15201935 1260848 IL-1 and are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP10 TNF 16549372 1582238 and OSM induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP10 TNF 17062332 1637222 To investigate the regulatory effects of fenofibrate on *induced* CD40 expression and [matrix metalloproteinase (MMP)] activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation MMP10 TNF 17469134 1737514 OSM and *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP10 TNF 17507431 1791856 Moreover , [MMP] activity in PCPEC supernatants was significantly *increased* by , presumably due to a diminished expression of TIMP-3 that was similarly observed . Positive_regulation MMP10 TNF 17876544 1796343 A similar augmentation was also observed in *induced* cytokine and [MMP] secretion . Positive_regulation MMP10 TNF 19026560 2001507 suppressed collagen type II and aggrecan , but *increased* [MMP] and cytokine expression in chondrocytes compared to the non stimulated controls . Positive_regulation MMP10 TNF 19435506 2106970 does not *induce* [MMP] expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation MMP10 TNF 20007453 2210585 We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since *induced* superoxide production , [MMP] expression , and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma . Positive_regulation MMP10 TNF 20403361 2267424 While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha , however , [matrix metalloproteinase (MMP)] *activation* of may also be contributory . Positive_regulation MMP10 TNF 23417988 2843303 SUMO-2/3 was knocked down using small interfering RNA in SFs , and *induced* [MMP] production was determined by ELISA . Positive_regulation MMP10 TNF 23417988 2843336 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by TNF-a and selectively control *mediated* [MMP] expression via the NF-?B pathway . Positive_regulation MMP10 TNF 23603294 2795179 Furthermore , infliximab effectively attenuated the *induced* increases in [MMP] expression in cells that make up the BAB . Positive_regulation MMP10 TNF 7543547 314340 Northern hybridization assays showed pretranslational control of PMA- , basic fibroblast growth factor- , and *induced* [MMP] expression . Positive_regulation MMP10 TNF 8349617 227079 Expression of keratinocyte [SL-2] was also *induced* by the two keratinocyte growth factors , transforming growth factor-alpha and epidermal growth factor , by the proinflammatory cytokine , , but , somewhat surprisingly , not by interleukin-1 beta . Positive_regulation MMP10 TNF 9014820 405410 In support of this result , stimulation *induced* membrane-type matrix metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation MMP10 TNF 9558121 500081 Recombinant and IL-1beta added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP10 TNF 9631748 512562 *increased* the total [MMP] activity released . Positive_regulation MMP10 TNF 9927150 588411 In general , *stimulated* both [MMP] and TIMP expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation MMP10 TNF 9933437 589385 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by IL-1beta and or down-regulated by IFN-gamma . Positive_regulation MMP11 CAPN8 21911754 2496950 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP11 CAPN8 21964156 2525728 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP11 CAPN8 22316244 2553234 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP11 CTGF 18632843 1979312 In conclusion , upregulation of inhibits BMP-7 signal transduction in the diabetic kidney and *contributes* to altered gene transcription , reduced [MMP] activity , glomerular basement membrane thickening , and albuminuria , all of which are hallmarks of diabetic nephropathy . Positive_regulation MMP11 EPHB2 14709335 1196640 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP11 EPHB2 20843518 2353061 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and *dependent* [MMP] expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation MMP11 EPHB2 24012928 2862348 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an [MMP] *inhibitor* , or PD98059 ( 50 µM ) , an inhibitor , also suppressed it . Positive_regulation MMP11 GNE 16847058 1606782 Cellular responses to the *mediated* changes in [ST3Gal5] and ST8Sia1 expression and GM3 and GD3 levels were investigated next . Positive_regulation MMP11 IGFBP1 15590975 1346150 Cell numbers were increased only by 100 nM IGFBP-1 isoforms ( P < 0.05 ) , whereas [MMP] levels released from term cells were optimally *increased* by 1-10 nM . Positive_regulation MMP11 IL1B 10727770 678120 and TPA alone *induced* [MMP] activity in HIG-82 cells . Positive_regulation MMP11 IL1B 10864917 705831 and TNF-alpha each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP11 IL1B 10895370 711603 In support of this result , stimulation *induced* the expression of membrane type matrix-metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation MMP11 IL1B 11327259 807569 A decrease in IL-1alpha , , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP11 IL1B 11467889 840794 In all cases , PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on *induction* of [MMP] expression . Positive_regulation MMP11 IL1B 11997239 939293 produced a dose dependent *increase* in [MMP] activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min . Positive_regulation MMP11 IL1B 14872494 1208447 Preincubation with anti-CD44 antibody , which suppressed IL-1beta stimulated MMPs , reversed the inhibitory effect of HA on [MMP] production that was *induced* by in normal and OA cartilage . Positive_regulation MMP11 IL1B 16449361 1573872 HA at > or =2 mg/ml significantly inhibited [MMP] production *induced* by in a dose dependent manner . Positive_regulation MMP11 IL1B 16449361 1573894 Inhibition studies revealed the requirement of NF-kappaB , p38 and c-jun NH2-terminal kinase ( JNK ) for *induced* [MMP] production . Positive_regulation MMP11 IL1B 17328062 1711895 SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on *stimulated* [MMP] production and collagen degradation . Positive_regulation MMP11 IL1B 17925024 1835261 These findings demonstrate , for the first time , that glucosamine inhibits *stimulated* [MMP] production in human chondrocytes by affecting MAPK phosphorylation . Positive_regulation MMP11 IL1B 18403593 1899527 DHA significantly decreased VSMC migration/proliferation *induced* by as well as [fibrinolytic/MMP] activity . Positive_regulation MMP11 IL1B 18535174 1928794 *stimulated* [MMP] mRNA synthesis in wild-type , but not in IL-1RI-null cardiac fibroblasts . Positive_regulation MMP11 IL1B 19056796 2017711 Cordycepin is a potent inhibitor of *induced* chemokine production and [MMP] expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs . Positive_regulation MMP11 IL1B 19542681 2099194 *induced* [MMP] production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ) , p38 kinase , and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase (MAPK) family signal transduction molecules . Positive_regulation MMP11 IL1B 20403707 2282282 *induced* [MMP] production was significantly augmented in the presence of sIL-6R . Positive_regulation MMP11 IL1B 21344389 2480438 These findings establish CEBPB as a critical intermediate for dependent [MMP] gene *activation* and assign specific roles for the ERK and RSK kinases in this pathway . Positive_regulation MMP11 IL1B 22792188 2628379 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation MMP11 IL1B 9558121 500084 Recombinant TNF-alpha and added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP11 IL1B 9821179 548116 The inflammatory cytokine did not *induce* [MMP] or TIMP expression . Positive_regulation MMP11 IL1B 9890433 585413 A beta , but not or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells , as well as *increased* the expression of the well-known activator of MMP-2 , membrane-type ( MT ) [-MMP] . Positive_regulation MMP11 IL1B 9933437 589388 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by and TNF-alpha or down-regulated by IFN-gamma . Positive_regulation MMP11 MAP2K6 19833163 2196111 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP11 MAP2K6 20545600 2308405 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP11 MAP2K6 22310287 2718939 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP11 PODXL 17616675 1769330 These findings suggest that leads to increased in vitro migration and invasion , *increased* [MMP] expression , and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MMP11 TGM2 24130925 2714720 Gene silencing of *suppressed* the [MMP] expression by ATRA . Positive_regulation MMP11 TLR7 18802113 1964706 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP11 TNF 10482270 643776 We also examined the possibility that such MMPs could be produced by brain derived cells , and that [MMP] production by these cells might be *increased* by , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD . Positive_regulation MMP11 TNF 10864917 705830 IL-1beta and each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP11 TNF 11147175 760922 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that may *induce* [MMP] production followed by matrix degradation within foreign body granulomas . Positive_regulation MMP11 TNF 11773040 899399 Isolated RMVECs did not significantly increase [MMP] production directly in response to a hypoxic stimulus , but *required* the presence of exogenous . Positive_regulation MMP11 TNF 12113550 963863 Because elevation of COX-2 mRNA levels enhances the production of prostaglandins , we therefore investigated whether endogenous prostaglandins are involved in the [MMP] mRNA expression that is *enhanced* by . Positive_regulation MMP11 TNF 12606436 1064567 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP11 TNF 12909329 1121947 *mediates* the stretch induced [MMP] genes expression , at least in part , through the JNK pathway . Positive_regulation MMP11 TNF 14673992 1178626 The in vivo data clearly indicated that OSM + overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP11 TNF 15044327 1272757 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to dependent [MMP] *induction* in the macrophages . Positive_regulation MMP11 TNF 15184206 1280573 *causes* increased [MMP] production , but some increased MMP activity is present even in TNFRKO mice . Positive_regulation MMP11 TNF 15201935 1260850 IL-1 and are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP11 TNF 16549372 1582240 and OSM induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP11 TNF 17062332 1637223 To investigate the regulatory effects of fenofibrate on *induced* CD40 expression and [matrix metalloproteinase (MMP)] activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation MMP11 TNF 17469134 1737516 OSM and *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP11 TNF 17507431 1791857 Moreover , [MMP] activity in PCPEC supernatants was significantly *increased* by , presumably due to a diminished expression of TIMP-3 that was similarly observed . Positive_regulation MMP11 TNF 17876544 1796344 A similar augmentation was also observed in *induced* cytokine and [MMP] secretion . Positive_regulation MMP11 TNF 19026560 2001508 suppressed collagen type II and aggrecan , but *increased* [MMP] and cytokine expression in chondrocytes compared to the non stimulated controls . Positive_regulation MMP11 TNF 19435506 2106971 does not *induce* [MMP] expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation MMP11 TNF 20007453 2210586 We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since *induced* superoxide production , [MMP] expression , and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma . Positive_regulation MMP11 TNF 20403361 2267425 While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha , however , [matrix metalloproteinase (MMP)] *activation* of may also be contributory . Positive_regulation MMP11 TNF 23417988 2843304 SUMO-2/3 was knocked down using small interfering RNA in SFs , and *induced* [MMP] production was determined by ELISA . Positive_regulation MMP11 TNF 23417988 2843337 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by TNF-a and selectively control *mediated* [MMP] expression via the NF-?B pathway . Positive_regulation MMP11 TNF 23603294 2795180 Furthermore , infliximab effectively attenuated the *induced* increases in [MMP] expression in cells that make up the BAB . Positive_regulation MMP11 TNF 24099577 2888778 In the present study , we show that the induced *up-regulation* of the [ST3GAL4] BX transcript is mediated by MSK1/2 ( mitogen- and stress activated kinase 1/2 ) through the ERK ( extracellular-signal regulated kinase ) and p38 MAPK ( mitogen activated protein kinase ) pathways , and increases sLe ( x ) expression on high-molecular-mass glycoproteins in inflamed airway epithelium . Positive_regulation MMP11 TNF 7543547 314341 Northern hybridization assays showed pretranslational control of PMA- , basic fibroblast growth factor- , and *induced* [MMP] expression . Positive_regulation MMP11 TNF 9014820 405411 In support of this result , stimulation *induced* membrane-type matrix metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation MMP11 TNF 9558121 500083 Recombinant and IL-1beta added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP11 TNF 9631748 512563 *increased* the total [MMP] activity released . Positive_regulation MMP11 TNF 9927150 588412 In general , *stimulated* both [MMP] and TIMP expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation MMP11 TNF 9933437 589387 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by IL-1beta and or down-regulated by IFN-gamma . Positive_regulation MMP12 CAPN8 21911754 2496964 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP12 CAPN8 21964156 2525742 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP12 CAPN8 22316244 2553248 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP12 CTGF 18632843 1979313 In conclusion , upregulation of inhibits BMP-7 signal transduction in the diabetic kidney and *contributes* to altered gene transcription , reduced [MMP] activity , glomerular basement membrane thickening , and albuminuria , all of which are hallmarks of diabetic nephropathy . Positive_regulation MMP12 EPHB2 14709335 1196642 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP12 EPHB2 20843518 2353062 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and *dependent* [MMP] expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation MMP12 EPHB2 24012928 2862349 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an [MMP] *inhibitor* , or PD98059 ( 50 µM ) , an inhibitor , also suppressed it . Positive_regulation MMP12 FUT4 22799384 2628626 *enhances* expression of [MMP-12] stimulated by EGF via the ERK1/2 , p38 and NF-?B pathways in A431 cells . Positive_regulation MMP12 FUT4 22799384 2628630 Importantly , we showed that *up-regulated* EGF induced [MMP-12] expression by promoting the phosphorylation of ERK1/2 and p38 MAPK , thereby inducing phosphorylation/ degradation of I?Ba , NF-?B activation . Positive_regulation MMP12 IGFBP1 15590975 1346151 Cell numbers were increased only by 100 nM IGFBP-1 isoforms ( P < 0.05 ) , whereas [MMP] levels released from term cells were optimally *increased* by 1-10 nM . Positive_regulation MMP12 IL1B 10727770 678121 and TPA alone *induced* [MMP] activity in HIG-82 cells . Positive_regulation MMP12 IL1B 10864917 705833 and TNF-alpha each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP12 IL1B 10895370 711604 In support of this result , stimulation *induced* the expression of membrane type matrix-metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation MMP12 IL1B 11327259 807572 A decrease in IL-1alpha , , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP12 IL1B 11467889 840795 In all cases , PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on *induction* of [MMP] expression . Positive_regulation MMP12 IL1B 11997239 939294 produced a dose dependent *increase* in [MMP] activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min . Positive_regulation MMP12 IL1B 14872494 1208448 Preincubation with anti-CD44 antibody , which suppressed IL-1beta stimulated MMPs , reversed the inhibitory effect of HA on [MMP] production that was *induced* by in normal and OA cartilage . Positive_regulation MMP12 IL1B 16359550 1494031 Selective inhibitors of extracellular signal regulated kinase , c-Jun N-terminal kinase and phosphatidylinositol 3-kinase reduced the activity of IL-1beta on MMP-12 , indicating a role for these kinases in *induced* induction and release of [MMP-12] . Positive_regulation MMP12 IL1B 16359550 1494033 *induced* [MMP-12] activity and gene expression was down-regulated by the corticosteroid dexamethasone but up-regulated by the inflammatory cytokine tumour necrosis factor (TNF)-alpha through enhancing activator protein-1 activation by IL-1beta . Positive_regulation MMP12 IL1B 16449361 1573873 HA at > or =2 mg/ml significantly inhibited [MMP] production *induced* by in a dose dependent manner . Positive_regulation MMP12 IL1B 16449361 1573895 Inhibition studies revealed the requirement of NF-kappaB , p38 and c-jun NH2-terminal kinase ( JNK ) for *induced* [MMP] production . Positive_regulation MMP12 IL1B 17328062 1711896 SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on *stimulated* [MMP] production and collagen degradation . Positive_regulation MMP12 IL1B 17925024 1835275 These findings demonstrate , for the first time , that glucosamine inhibits *stimulated* [MMP] production in human chondrocytes by affecting MAPK phosphorylation . Positive_regulation MMP12 IL1B 18403593 1899528 DHA significantly decreased VSMC migration/proliferation *induced* by as well as [fibrinolytic/MMP] activity . Positive_regulation MMP12 IL1B 18535174 1928795 *stimulated* [MMP] mRNA synthesis in wild-type , but not in IL-1RI-null cardiac fibroblasts . Positive_regulation MMP12 IL1B 18547653 1940573 The temporal expression of MMP-12 largely corresponded to that of cytokines , and we demonstrate that and TNF-alpha *promoted* [MMP-12] expression in cultured macrophages . Positive_regulation MMP12 IL1B 18980250 1995275 Our results indicate that in chondrocytes *induces* the expression and activation of [MMP-12] , which , in turn , augments MMP-9 expression and activation . Positive_regulation MMP12 IL1B 19056796 2017712 Cordycepin is a potent inhibitor of *induced* chemokine production and [MMP] expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs . Positive_regulation MMP12 IL1B 19542681 2099195 *induced* [MMP] production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ) , p38 kinase , and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase (MAPK) family signal transduction molecules . Positive_regulation MMP12 IL1B 20403707 2282283 *induced* [MMP] production was significantly augmented in the presence of sIL-6R . Positive_regulation MMP12 IL1B 21344389 2480439 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Positive_regulation MMP12 IL1B 22792188 2628380 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation MMP12 IL1B 9558121 500086 Recombinant TNF-alpha and added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP12 IL1B 9821179 548117 The inflammatory cytokine did not *induce* [MMP] or TIMP expression . Positive_regulation MMP12 IL1B 9890433 585414 A beta , but not or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells , as well as *increased* the expression of the well-known activator of MMP-2 , membrane-type ( MT ) [-MMP] . Positive_regulation MMP12 IL1B 9933437 589390 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by and TNF-alpha or down-regulated by IFN-gamma . Positive_regulation MMP12 MAP2K6 19833163 2196118 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP12 MAP2K6 20545600 2308412 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP12 MAP2K6 22310287 2718946 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP12 MMP28 12783419 1096324 ICH increased brain MMP-2 , -3 , -7 , and -9 mRNA levels relative to sham injected ( control ) animals in the vicinity of the hematoma , but [MMP-12] ( macrophage metalloelastase ) was the most highly *induced* ( > 80-fold ) . Positive_regulation MMP12 MMP28 19422332 2076136 Moreover , PBMC derived fibroblast-like cells expressed high levels of MMP-9 and [MMP-12] and their migration was *inhibited* by inhibitors in a wound healing assay . Positive_regulation MMP12 MMP7 12783419 1096339 ICH increased brain MMP-2 , -3 , -7 , and -9 mRNA levels relative to sham injected ( control ) animals in the vicinity of the hematoma , but [MMP-12] ( macrophage metalloelastase ) was the most highly *induced* ( > 80-fold ) . Positive_regulation MMP12 MMP7 19422332 2076151 Moreover , PBMC derived fibroblast-like cells expressed high levels of MMP-9 and [MMP-12] and their migration was *inhibited* by inhibitors in a wound healing assay . Positive_regulation MMP12 PODXL 17616675 1769331 These findings suggest that leads to increased in vitro migration and invasion , *increased* [MMP] expression , and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MMP12 TGM2 24130925 2714721 Gene silencing of *suppressed* the [MMP] expression by ATRA . Positive_regulation MMP12 TLR7 18802113 1964716 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP12 TNF 10482270 643777 We also examined the possibility that such MMPs could be produced by brain derived cells , and that [MMP] production by these cells might be *increased* by , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD . Positive_regulation MMP12 TNF 10864917 705832 IL-1beta and each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP12 TNF 11147175 760923 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that may *induce* [MMP] production followed by matrix degradation within foreign body granulomas . Positive_regulation MMP12 TNF 11704502 879097 Unlike basic fibroblast growth factor (bFGF) and transforming growth factor-beta ( TGF-beta ) , *induced* [MMP-12] mRNA production in chondrosarcoma derived HTB-94 cells . Positive_regulation MMP12 TNF 11773040 899400 Isolated RMVECs did not significantly increase [MMP] production directly in response to a hypoxic stimulus , but *required* the presence of exogenous . Positive_regulation MMP12 TNF 12113550 963864 Because elevation of COX-2 mRNA levels enhances the production of prostaglandins , we therefore investigated whether endogenous prostaglandins are involved in the [MMP] mRNA expression that is *enhanced* by . Positive_regulation MMP12 TNF 12606436 1064569 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP12 TNF 12909329 1121948 *mediates* the stretch induced [MMP] genes expression , at least in part , through the JNK pathway . Positive_regulation MMP12 TNF 14673992 1178628 The in vivo data clearly indicated that OSM + overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP12 TNF 15044327 1272758 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to dependent [MMP] *induction* in the macrophages . Positive_regulation MMP12 TNF 15184206 1280574 *causes* increased [MMP] production , but some increased MMP activity is present even in TNFRKO mice . Positive_regulation MMP12 TNF 15201935 1260852 IL-1 and are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP12 TNF 15781250 1385460 Enbrel , an inhibitor of function , *reduced* CSC induced H ( 2 ) O ( 2 ) production and [MMP-12] expression . Positive_regulation MMP12 TNF 16549372 1582242 and OSM induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP12 TNF 17062332 1637224 To investigate the regulatory effects of fenofibrate on *induced* CD40 expression and [matrix metalloproteinase (MMP)] activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation MMP12 TNF 17469134 1737518 OSM and *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP12 TNF 17507431 1791858 Moreover , [MMP] activity in PCPEC supernatants was significantly *increased* by , presumably due to a diminished expression of TIMP-3 that was similarly observed . Positive_regulation MMP12 TNF 17876544 1796345 A similar augmentation was also observed in *induced* cytokine and [MMP] secretion . Positive_regulation MMP12 TNF 18547653 1940572 The temporal expression of MMP-12 largely corresponded to that of cytokines , and we demonstrate that IL-1beta and *promoted* [MMP-12] expression in cultured macrophages . Positive_regulation MMP12 TNF 19026560 2001509 suppressed collagen type II and aggrecan , but *increased* [MMP] and cytokine expression in chondrocytes compared to the non stimulated controls . Positive_regulation MMP12 TNF 19435506 2106972 does not *induce* [MMP] expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation MMP12 TNF 20007453 2210587 We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since *induced* superoxide production , [MMP] expression , and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma . Positive_regulation MMP12 TNF 20051654 2200939 Possible involvements of nuclear factor-kappa B and activator protein-1 in the *induced* upregulation of [matrix metalloproteinase-12] in human alveolar epithelial A549 cell line . Positive_regulation MMP12 TNF 20051654 2200942 Furthermore , siRNAs for p65 and JNK2 were used to confirm the involvements of nuclear factor-kappaB (NF-kappaB) and AP-1 in the [MMP-12] mRNA expression *induced* by in A549 cells . Positive_regulation MMP12 TNF 20051654 2200946 Furthermore , both the depletion of p65 and JNK2 by siRNAs significantly attenuated the upregulation of [MMP-12] *induced* by . Positive_regulation MMP12 TNF 20051654 2200949 These findings suggest that both NF-kappaB and JNK / AP-1 pathways are important for the [MMP-12] upregulation *induced* by in A549 cells . Positive_regulation MMP12 TNF 20403361 2267426 While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha , however , [matrix metalloproteinase (MMP)] *activation* of may also be contributory . Positive_regulation MMP12 TNF 22424696 2588100 Furthermore , [MMP-12] production was *increased* by IL-6 and in THP-1 macrophages but it was not detectable in THP-1 monocytes . Positive_regulation MMP12 TNF 22424696 2588124 In conclusion , gAd played an important role in CCL20 expression , and [MMP-12] *induced* by IL-6 or was involved in the synergistic effect of fAd and cytokines . Positive_regulation MMP12 TNF 23417988 2843305 SUMO-2/3 was knocked down using small interfering RNA in SFs , and *induced* [MMP] production was determined by ELISA . Positive_regulation MMP12 TNF 23417988 2843338 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by TNF-a and selectively control *mediated* [MMP] expression via the NF-?B pathway . Positive_regulation MMP12 TNF 23603294 2795181 Furthermore , infliximab effectively attenuated the *induced* increases in [MMP] expression in cells that make up the BAB . Positive_regulation MMP12 TNF 7543547 314342 Northern hybridization assays showed pretranslational control of PMA- , basic fibroblast growth factor- , and *induced* [MMP] expression . Positive_regulation MMP12 TNF 7680963 214189 Flow cytometric analyses revealed that [murine microvascular endothelium (MME)] in culture constitutively expresses VCAM-1 and that stimulation of MME by , IL-1 , or LPS , but not by PMA or staurosporine , strongly *increased* the surface expression of this cell adhesion molecule . Positive_regulation MMP12 TNF 9014820 405412 In support of this result , stimulation *induced* membrane-type matrix metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation MMP12 TNF 9558121 500085 Recombinant and IL-1beta added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP12 TNF 9631748 512564 *increased* the total [MMP] activity released . Positive_regulation MMP12 TNF 9927150 588413 In general , *stimulated* both [MMP] and TIMP expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation MMP12 TNF 9933437 589389 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by IL-1beta and or down-regulated by IFN-gamma . Positive_regulation MMP12 WNT7A 15802269 1410465 induced the accumulation of beta-catenin and the activation of Rac and beta-catenin , and Rac synergistically *induced* the transcription of [MMP-12] . Positive_regulation MMP13 CAPN8 21911754 2496978 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP13 CAPN8 21964156 2525756 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP13 CAPN8 22316244 2553262 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP13 CTGF 18632843 1979314 In conclusion , upregulation of inhibits BMP-7 signal transduction in the diabetic kidney and *contributes* to altered gene transcription , reduced [MMP] activity , glomerular basement membrane thickening , and albuminuria , all of which are hallmarks of diabetic nephropathy . Positive_regulation MMP13 CTGF 19301259 2064219 *enhances* migration and [MMP-13] up-regulation via alphavbeta3 integrin , FAK , ERK , and NF-kappaB dependent pathway in human chondrosarcoma cells . Positive_regulation MMP13 CTGF 19301259 2064228 RGD peptide , alphavbeta3 monoclonal antibody ( mAb ) and MAPK kinase ( MEK ) inhibitors ( PD98059 and U0126 ) but not RAD peptide inhibited the *induced* increase of the migration and [MMP-13] up-regulation of chondrosarcoma cells . Positive_regulation MMP13 CTGF 19301259 2064248 In addition , treatment of JJ012 cells with NF-kappaB inhibitor ( PDTC ) or IkappaB protease inhibitor ( TPCK ) inhibited *induced* cell migration and [MMP-13] up-regulation . Positive_regulation MMP13 EPHB2 12730223 1100644 FN-f stimulated [MMP-13] promoter activity was also *inhibited* by chemical inhibitors of , JNK , and p38 mitogen activated protein ( MAP ) kinases or by co-transfection of dominant negative MAP kinase mutant constructs . Positive_regulation MMP13 EPHB2 12878172 1115507 Inhibitors of ( U0126 , PD98059 , and ERK1/2 antisense phosphorothioate oligonucleotide ) , JNK ( SB203580 , SP600125 , and curcumin ) , and p38 ( SB203580 and SB202190 ) pathways *down-regulated* the TNF stimulated expression of [MMP-13] . Positive_regulation MMP13 EPHB2 12878172 1115510 These results suggest that induction of the [MMP-13] gene by TNF-alpha is *mediated* by , p38 , and JNK MAP kinases as well as AP-1 and NF-kappaB transcription factors . Positive_regulation MMP13 EPHB2 14575638 1156214 We previously showed that palytoxin *requires* to increase [matrix metalloproteinase-13 (MMP-13)] gene expression , an enzyme implicated in carcinogenesis . Positive_regulation MMP13 EPHB2 14575638 1156216 Accordingly , activation , independent of palytoxin and in the absence of JNK and p38 activation , is *sufficient* to induce [MMP-13] gene expression in 308 keratinocytes . Positive_regulation MMP13 EPHB2 14634122 1170898 Pharmacologic inhibitors of *inhibited* MMP-1 , but not [MMP-13] expression . Positive_regulation MMP13 EPHB2 14634122 1170911 Our data indicate that : 1 ) activation *mediates* MMP-1 but not [MMP-13] release from FLSCs , 2 ) COX-2 derived E PGs inhibit MMP-1 release from FLSCs via inhibition of ERK , and 3 ) COX inhibitors , by attenuating PGE inhibition of ERK , enhance the release of MMP-1 by FLSC . Positive_regulation MMP13 EPHB2 14709335 1196644 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP13 EPHB2 15564063 1341404 Inhibitors of signaling *blocked* up-regulation of the [MMP-13] promoter by RUNX2 and FGF2 , and also blocked the activation of RUNX2 by FGF2 . Positive_regulation MMP13 EPHB2 16198011 1468458 We also determined that activities of tyrosine kinase and and JNK MAP kinases were *required* for this collagen induced [MMP-13] expression . Positive_regulation MMP13 EPHB2 16468044 1573946 Inhibitors of and NFkappaB could significantly *block* the induction of [MMP-1 and -13] ( p < 0.05 ) and the repression of collagen type II ( p < 0.01 ) . Positive_regulation MMP13 EPHB2 18487224 1944909 CXCL12 seems to enhance LHSCC cell invasion through paracrine activated CXCR4 , which triggers *dependent* [MMP-13] upregulation . Positive_regulation MMP13 EPHB2 19542681 2099211 An pathway inhibitor ( U0126 ) , but not a p38 kinase inhibitor ( SB203580 ) or a JNK inhibitor ( SP600125 ) , also selectively *inhibited* IL-1beta induced [MMP-13] production in HAC . Positive_regulation MMP13 EPHB2 20843518 2353063 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and *dependent* [MMP] expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation MMP13 EPHB2 22158614 2542868 Further , we found that signaling *enhances* ELF3-driven [MMP13] transactivation and is required for IL-1ß induced ELF3 binding to the MMP13 promoter , as assessed by chromatin immunoprecipitation . Positive_regulation MMP13 EPHB2 24012928 2862350 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an [MMP] *inhibitor* , or PD98059 ( 50 µM ) , an inhibitor , also suppressed it . Positive_regulation MMP13 IGFBP1 15590975 1346152 Cell numbers were increased only by 100 nM IGFBP-1 isoforms ( P < 0.05 ) , whereas [MMP] levels released from term cells were optimally *increased* by 1-10 nM . Positive_regulation MMP13 IL1B 10727770 678122 and TPA alone *induced* [MMP] activity in HIG-82 cells . Positive_regulation MMP13 IL1B 10864917 705835 and TNF-alpha each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP13 IL1B 10895370 711605 In support of this result , stimulation *induced* the expression of membrane type matrix-metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation MMP13 IL1B 11263774 796478 Treatment of chondrocytes with PPARgamma ligands BRL 49653 and 15-deoxy-delta12,14-prostaglandin J2 ( 15d-PGJ2 ) , but not with PPARalpha ligand Wy 14643 , decreased *induced* NO and [MMP-13] production in a dose dependent manner . Positive_regulation MMP13 IL1B 11263774 796482 The findings of this study demonstrate that PPARgamma agonists inhibit *induction* of both NO and [MMP-13] in human chondrocytes . Positive_regulation MMP13 IL1B 11327259 807575 A decrease in IL-1alpha , , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP13 IL1B 11453113 836953 We tested the effect of interleukin(IL)-1beta , a proinflammatory cytokine , on collagenase-2 gene expression in cultured human gingival fibroblasts and also compared this effect with *induced* changes in [collagenase-1 and -3] gene expression . Positive_regulation MMP13 IL1B 11467889 840796 In all cases , PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on *induction* of [MMP] expression . Positive_regulation MMP13 IL1B 11732857 885245 *induced* the expressions of MMP-1 , [MMP-13] , and GLS mRNAs and proteins in a dose dependent manner . Positive_regulation MMP13 IL1B 11883937 919743 In OA chondrocytes , the type of complex discriminated two groups -- the low-OA chondrocytes , showing low collagenase-3 basal levels and high inducibility of IL-1beta stimulation ( complex 1 ) , and the high-OA chondrocytes with high [collagenase-3] basal levels and low *inducibility* ( a faster migrating complex , designated complex 2 ) . Positive_regulation MMP13 IL1B 11997239 939295 produced a dose dependent *increase* in [MMP] activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min . Positive_regulation MMP13 IL1B 12064845 953427 Interleukin 17 (IL-17) *induces* [collagenase-3] production in human osteoarthritic chondrocytes via AP-1 dependent activation : differential activation of AP-1 members by IL-17 and . Positive_regulation MMP13 IL1B 12064845 953438 Of note , in OA chondrocytes , IL-17 and *induced* [collagenase-3] production through AP-1 occurred with differential protein complexes : IL-17 stimulation resulted in FosB activation , while IL-1beta stimulated c-Fos . Positive_regulation MMP13 IL1B 12064845 953445 We demonstrated that IL-17 and *induced* [collagenase-3] production in OA chondrocytes mainly through AP-1 mediated transcriptional activity but with differential protein complexes , suggesting that some AP-1 proteins play a pivotal role in the different cytokine responses in terms of collagenase-3 production . Positive_regulation MMP13 IL1B 12096844 961156 In primary culture of Cbfa1-/- chondrocytes , transforming growth factor (TGF) beta1 , platelet derived growth factor ( PDGF ) , , and thyroid hormone ( T3 ) *induced* osteopontin and [MMP-13] expression . Positive_regulation MMP13 IL1B 12115742 964352 On the other hand , *induced* [MMP-13] synthesis was elevated on Day 3 , declined on Day 5 , and then increased again through Day 14 . Positive_regulation MMP13 IL1B 12384923 999424 MMP-1 and [MMP-13] were expressed much higher in vitro than in vivo and were *up-regulated* by . Positive_regulation MMP13 IL1B 12734180 1107008 In this study , we investigated the inhibitory effects of insulin-like growth factor-1 (IGF-1) and osteogenic protein-1 (OP-1) on the expression of [MMP-13] , which was *induced* by fibronectin fragment or in human immortalized or human primary chondrocytes . Positive_regulation MMP13 IL1B 14600251 1200292 Green tea polyphenol epigallocatechin-3-gallate ( EGCG ) differentially inhibits *induced* expression of [matrix metalloproteinase-1 and -13] in human chondrocytes . Positive_regulation MMP13 IL1B 14872494 1208449 Preincubation with anti-CD44 antibody , which suppressed IL-1beta stimulated MMPs , reversed the inhibitory effect of HA on [MMP] production that was *induced* by in normal and OA cartilage . Positive_regulation MMP13 IL1B 14872494 1208463 This study demonstrates that HA effectively inhibits *stimulated* production of MMP-1 , MMP-3 , and [MMP-13] , which supports the clinical use of HA in the treatment of OA . Positive_regulation MMP13 IL1B 15125014 1244618 In contrast , CMT-5 only inhibited PTH stimulated MMP-13 expression , with no effect on or TNF-alpha *stimulated* [MMP-13] expression . Positive_regulation MMP13 IL1B 15640153 1381320 In contrast , secretion of [MMP-13] was *stimulated* by but not EGF and was Erk independent and mediated by p38 . Positive_regulation MMP13 IL1B 15860218 1400798 FK506 suppresses the *stimulation* of [matrix metalloproteinase 13] synthesis by in rheumatoid synovial fibroblasts . Positive_regulation MMP13 IL1B 15950496 1434325 In both cell systems matrix metalloproteinase-1 (MMP-1) , MMP-3 and [MMP-13] were strongly *induced* by , without significant induction of MMP-2 . Positive_regulation MMP13 IL1B 15979654 1459107 [MMP-13] expression increased markedly in the *presence* of on day 1 of culture , but decreased markedly after day 7 . Positive_regulation MMP13 IL1B 16148020 1482436 [MMP-13] was expressed by tendon cells at lower levels than MMP-1 , and was *stimulated* typically 10- to 100-fold by . Positive_regulation MMP13 IL1B 16399619 1513037 In human primary chondrocytes , the production of [matrix metalloproteinase-13] and -1 ( MMP-13 and -1 ) and prostaglandin E2 ( PGE2 ) was *induced* by . Positive_regulation MMP13 IL1B 16449361 1573874 HA at > or =2 mg/ml significantly inhibited [MMP] production *induced* by in a dose dependent manner . Positive_regulation MMP13 IL1B 16449361 1573896 Inhibition studies revealed the requirement of NF-kappaB , p38 and c-jun NH2-terminal kinase ( JNK ) for *induced* [MMP] production . Positive_regulation MMP13 IL1B 16549373 1582332 and TNFalpha strongly *induced* the expression of [MMP-1 and -13] in SW1353 cells and HACs , whereas only TNFalpha was found to induce the expression of these two MMPs in JJ012 cells . Positive_regulation MMP13 IL1B 17009243 1634028 OSM potentiated *induced* MMP-1 and [MMP-13] expression in normal human cartilage/RASF cocultures , resulting in a significant increase in the MMP : TIMP ratio . Positive_regulation MMP13 IL1B 17179173 1740227 Knockdown of the STAT1 gene by specific siRNA or its inhibition with fludarabine partially restored the *induction* of [MMP13] expression and promoter activity . Positive_regulation MMP13 IL1B 17328062 1711897 SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on *stimulated* [MMP] production and collagen degradation . Positive_regulation MMP13 IL1B 17697361 1835023 *increased* the transcriptional and translational levels of MMP-1 and [MMP-13] in rheumatoid arthritis FLSs , whereas the levels of MMP-2 and MMP-9 were unaffected . Positive_regulation MMP13 IL1B 17925024 1835289 These findings demonstrate , for the first time , that glucosamine inhibits *stimulated* [MMP] production in human chondrocytes by affecting MAPK phosphorylation . Positive_regulation MMP13 IL1B 18403593 1899529 DHA significantly decreased VSMC migration/proliferation *induced* by as well as [fibrinolytic/MMP] activity . Positive_regulation MMP13 IL1B 18427719 1920717 We investigated the intracellular mechanism for the inhibitory effects of hyaluronan ( HA ) on *stimulated* [collagenase-1 and -3] ( matrix metalloproteinases ( MMPs ) -1 and -13 ) production in a human chondrosarcoma cell line , SW-1353 . Positive_regulation MMP13 IL1B 18427719 1920738 The present study clearly suggests that HA binds CD44 and inhibits *induced* [MMP-1 and -13] expression via down-regulation of Phos-p38 in SW-1353 cells . Positive_regulation MMP13 IL1B 18433786 1908057 significantly *induced* ( p < 0.01 ) matrix metalloproteinase-1 , 3 , 10 and 13 protein production , endogenous [matrix metalloproteinase-13] activity ( 12-fold ) and matrix metalloproteinase-13 mRNA expression ( 11.2-fold ) through a Ca ( 2+ ) independent mechanism in cultured fibroblasts . Positive_regulation MMP13 IL1B 18470577 1921584 Additionally , we hypothesized load induced changes in tenocyte [MMP-13] expression would be *dependent* on expression of . Positive_regulation MMP13 IL1B 18535174 1928796 *stimulated* [MMP] mRNA synthesis in wild-type , but not in IL-1RI-null cardiac fibroblasts . Positive_regulation MMP13 IL1B 18578867 1941036 Diacerein and rhein reduced , in a dose dependent manner , the *induced* [MMP-13] production in OA subchondral bone . Positive_regulation MMP13 IL1B 18975308 1983137 To investigate the effects of prostaglandin D2 (PGD2) on *induced* matrix metalloproteinase 1 (MMP-1) and [MMP-13] expression in human chondrocytes and the signaling pathways involved in these effects . Positive_regulation MMP13 IL1B 19046432 2006654 The goals of this study were to evaluate the inhibition of *induced* expression of MMP-1 and [MMP-13] by combinatorial treatment with RXR and PPARgamma ligands and to investigate the molecular mechanisms of this inhibition . Positive_regulation MMP13 IL1B 19046432 2006656 Combinatorial treatment activates each partner of the RXR : PPARgamma heterodimer and inhibits *induced* expression of MMP-1 and [MMP-13] more effectively than either compound alone . Positive_regulation MMP13 IL1B 19056796 2017713 Cordycepin is a potent inhibitor of *induced* chemokine production and [MMP] expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs . Positive_regulation MMP13 IL1B 19107653 2018862 Results showed that FGF2 and both *increased* [MMP-1 and -13] expression , while IL-1beta also increased MMP-3 mRNA levels . Positive_regulation MMP13 IL1B 19248089 2045029 [Matrix metalloproteinase 13] was *induced* by in a NF-kappaB dependent manner . Positive_regulation MMP13 IL1B 19296842 2080048 The objective of this study was to evaluate the expression of 15-lipoxygenase-1 and -2 in human articular chondrocytes , and to investigate the effects of their metabolites 13 ( S ) -hydroxy octadecadienoic and 15 ( S ) -hydroxyeicosatetraenoic acids on *induced* matrix metalloproteinase (MMP)-1 and [MMP-13] expression . Positive_regulation MMP13 IL1B 19296842 2080051 Their respective metabolites , namely 13 ( S ) -hydroxy octadecadienoic and 15 ( S ) -hydroxyeicosatetraenoic acids , suppressed *induced* MMP-1 and [MMP-13] expression in a PPARgamma dependent pathway . Positive_regulation MMP13 IL1B 19542681 2099183 The chondroprotective agent ITZ-1 inhibits *induced* [matrix metalloproteinase-13] production and suppresses nitric oxide induced chondrocyte death . Positive_regulation MMP13 IL1B 19542681 2099196 *induced* [MMP] production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ) , p38 kinase , and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase (MAPK) family signal transduction molecules . Positive_regulation MMP13 IL1B 19542681 2099212 An ERK-MAPK pathway inhibitor ( U0126 ) , but not a p38 kinase inhibitor ( SB203580 ) or a JNK inhibitor ( SP600125 ) , also selectively inhibited *induced* [MMP-13] production in HAC . Positive_regulation MMP13 IL1B 19656660 2125725 In HSF cells , treatment *induced* COX-2 and [MMP-13] expressions in association with activation of ERKs , p38 MAPK , JNKs , and NF-kappaB . Positive_regulation MMP13 IL1B 19998410 2199763 The objective of this study was to investigate direct effects of PGE2 on *induced* MMP-1 and [MMP-13] expression and the intracellular signaling in articular chondrocytes . Positive_regulation MMP13 IL1B 19998410 2199765 PGE2 showed inhibitory effects on *induced* MMP-1 and [MMP-13] expression demonstrated by immunoblotting both in OA and normal chondrocytes , which was further confirmed by enzyme linked immunosorbent assay and immunohistochemistry of explant cultures of articular cartilages . Positive_regulation MMP13 IL1B 19998410 2199767 These results demonstrate that PGE2 inhibits *induced* MMP-1 and [MMP-13] productions via EP4 by suppressing MKK4-JNK MAP kinase-c-JUN pathway . Positive_regulation MMP13 IL1B 20131257 2248432 Overexpression of miR-27b suppressed the activity of a reporter construct containing the 3'-UTR of human MMP-13 mRNA and inhibited the *induced* expression of [MMP-13] protein in chondrocytes . Positive_regulation MMP13 IL1B 20142037 2208145 ITZ-1 is a chondroprotective agent that inhibits *induced* [matrix metalloproteinase-13 (MMP-13)] production and suppresses nitric oxide induced chondrocyte death . Positive_regulation MMP13 IL1B 20403707 2282284 *induced* [MMP] production was significantly augmented in the presence of sIL-6R . Positive_regulation MMP13 IL1B 20590617 2285824 All p38MAPK inhibitors significantly inhibited the *induced* gene expression of COX-2 , mPGES1 , iNOS , [matrix metalloproteinase 13 (MMP13)] and TNFRSF11B , as well as PGE ( 2 ) release . Positive_regulation MMP13 IL1B 20633667 2310417 Inhibition of both p38alpha and p38gamma with BIRB796 resulted in less inhibition of [MMP-13] production in *response* to or FN-f than did inhibition of only p38alpha with SB203580 . Positive_regulation MMP13 IL1B 20685652 2322742 Sumoylation and nuclear translocation of S100A4 regulate *mediated* production of [matrix metalloproteinase-13] . Positive_regulation MMP13 IL1B 21344389 2480422 IL-1B treatment increased CEBPB expression in SW1353 cells over a 24-h period and knockdown of CEBPB with shRNA abrogated *dependent* MMP-1 and [MMP-13] gene activation . Positive_regulation MMP13 IL1B 21344389 2480440 These findings establish CEBPB as a critical intermediate for dependent [MMP] gene *activation* and assign specific roles for the ERK and RSK kinases in this pathway . Positive_regulation MMP13 IL1B 22792188 2628381 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation MMP13 IL1B 23034253 2684499 In the present study , we examined the effect of a marine bioactive compound containing high-purity caviar derived DNA , collagen elastin and protein extracts from sturgeon ( LD-1227 , Caviarlieri , Laboratoires Dom , Switzerland ) on *induced* activation and production of TNFalpha and [MMP-13] in human osteo-arthritis ( OA ) chondrocytes and intracellular signaling factors . Positive_regulation MMP13 IL1B 23034253 2684504 LD-1227 significantly decreased *stimulated* gene expression and production of TNFalpha , MMP-1 , [MMP-13] and Col10A1 in human chondrocytes . Positive_regulation MMP13 IL1B 9558121 500088 Recombinant TNF-alpha and added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP13 IL1B 9821179 548118 The inflammatory cytokine did not *induce* [MMP] or TIMP expression . Positive_regulation MMP13 IL1B 9890433 585415 A beta , but not or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells , as well as *increased* the expression of the well-known activator of MMP-2 , membrane-type ( MT ) [-MMP] . Positive_regulation MMP13 IL1B 9933437 589392 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by and TNF-alpha or down-regulated by IFN-gamma . Positive_regulation MMP13 MAP2K6 10601295 574432 In addition , activation of p38 MAPK by constitutively active or MKK3b was not *sufficient* to induce [MMP-13] expression . Positive_regulation MMP13 MAP2K6 15564063 1341411 Inhibitors of signaling *blocked* up-regulation of the [MMP-13] promoter by RUNX2 and FGF2 , and also blocked the activation of RUNX2 by FGF2 . Positive_regulation MMP13 MAP2K6 19301259 2064234 RGD peptide , alphavbeta3 monoclonal antibody ( mAb ) and MAPK kinase ( ) inhibitors ( PD98059 and U0126 ) but not RAD peptide *inhibited* the CTGF induced increase of the migration and [MMP-13] up-regulation of chondrosarcoma cells . Positive_regulation MMP13 MAP2K6 19833163 2196125 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP13 MAP2K6 20545600 2308419 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP13 MAP2K6 21075784 2389625 PKC , FAK , and JNK are *involved* in collagen stimulated expression of [MMP-13] . Positive_regulation MMP13 MAP2K6 22158614 2542875 Further , we found that signaling *enhances* ELF3-driven [MMP13] transactivation and is required for IL-1ß induced ELF3 binding to the MMP13 promoter , as assessed by chromatin immunoprecipitation . Positive_regulation MMP13 MAP2K6 22310287 2718953 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP13 MATN2 19840795 2165265 stimulation *leads* to the induction of MMP1 , MMP3 , [MMP13] , COX-2 , iNOS , IL-1beta , TNFalpha , IL-6 and IL-8 . Positive_regulation MMP13 MMP28 10190278 603321 Gelatinase A , [collagenase 3] and gelatinase B may be *activated* by based mechanisms , as evidenced by both biochemical and cell based studies . Positive_regulation MMP13 MMP7 10190278 603336 Gelatinase A , [collagenase 3] and gelatinase B may be *activated* by based mechanisms , as evidenced by both biochemical and cell based studies . Positive_regulation MMP13 MMP7 17017992 1630081 *activates* MMP-8 but not [MMP-13] . Positive_regulation MMP13 MMP7 17017992 1630083 Whether the additional collagenases , MMP-8 and [MMP-13] , are also *activated* by has not been explored . Positive_regulation MMP13 MMP7 17017992 1630085 We show here that recombinant active was able to process MMP-8 to its active form in vitro , but did not *activate* [MMP-13] . Positive_regulation MMP13 MMP7 7608162 311889 Rat and human do not directly *activate* latent rat [collagenase 3] ( matrix metalloproteinase 13 ) and do not enhance its activation when added together with APMA . Positive_regulation MMP13 PLAU 21913037 2674576 In conclusion , MMP-9 and might be *involved* in the activation of [pro-MMP-13] through unknown mechanisms in arthritic diseases . Positive_regulation MMP13 PODXL 17616675 1769332 These findings suggest that leads to increased in vitro migration and invasion , *increased* [MMP] expression , and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MMP13 S100B 16052547 1441987 The ability of and HMGB-1 to *stimulate* [matrix metalloproteinase 13 (MMP-13)] production was also assessed . Positive_regulation MMP13 S100B 16052547 1441989 Stimulation of chondrocytes with or HMGB-1 increased phosphorylation of the ERK MAP kinase and the p65 subunit of NF-kappaB and *increased* the production of [MMP-13] . Positive_regulation MMP13 SYNM 23485615 2771908 Reverse transcription polymerase chain reaction ( RT-PCR ) and western blot analyses revealed that CK inhibited *induced* increases in [matrix metalloproteinase-13 (MMP-13)] , tissue inhibitor of metalloproteinase-1 ( TIMP-1 ) , and tumor necrosis factor-a (TNF-a) mRNA , and collagen type I and a-smooth muscle actin protein . Positive_regulation MMP13 TGM2 24130925 2714722 Gene silencing of *suppressed* the [MMP] expression by ATRA . Positive_regulation MMP13 TLR7 18802113 1964726 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP13 TNF 10482270 643778 We also examined the possibility that such MMPs could be produced by brain derived cells , and that [MMP] production by these cells might be *increased* by , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD . Positive_regulation MMP13 TNF 10633074 659901 Selective inhibition of p38 activity with SB 203580 abolished the *enhancement* of [MMP-13] , as well as collagenase-1 ( MMP-1 ) and 92-kDa gelatinase ( MMP-9 ) expression by and TGF- ( beta ) . Positive_regulation MMP13 TNF 10633074 659903 Blocking the ERK1 , 2 pathway by PD 98059 had no effect on the *induction* of [MMP-13] expression by or TGF- ( beta ) , but potently suppressed MMP-1 and MMP-9 production . Positive_regulation MMP13 TNF 10645003 661759 IFN-gamma abolished the *enhancement* of [MMP-13] and MMP-1 expression by transforming growth factor-beta ( TGF-beta ) and , and inhibited invasion of A-5 cells through type I collagen . Positive_regulation MMP13 TNF 10864917 705834 IL-1beta and each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP13 TNF 11054671 745855 In these cell lines , potently *induced* [MMP-13] mRNA expression . Positive_regulation MMP13 TNF 11147175 760924 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that may *induce* [MMP] production followed by matrix degradation within foreign body granulomas . Positive_regulation MMP13 TNF 11773040 899401 Isolated RMVECs did not significantly increase [MMP] production directly in response to a hypoxic stimulus , but *required* the presence of exogenous . Positive_regulation MMP13 TNF 12010565 941225 Of these enzymes , the expression of MMP-1 and [MMP-13] is substantially increased in *response* to IL-1 and , and elevated levels of these collagenases are observed in arthritic tissues . Positive_regulation MMP13 TNF 12113550 963865 Because elevation of COX-2 mRNA levels enhances the production of prostaglandins , we therefore investigated whether endogenous prostaglandins are involved in the [MMP] mRNA expression that is *enhanced* by . Positive_regulation MMP13 TNF 12606436 1064571 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP13 TNF 12878172 1115503 *Induction* of [matrix metalloproteinase-13] gene expression by is mediated by MAP kinases , AP-1 , and NF-kappaB transcription factors in articular chondrocytes . Positive_regulation MMP13 TNF 12878172 1115506 Inhibitors of ERK ( U0126 , PD98059 , and ERK1/2 antisense phosphorothioate oligonucleotide ) , JNK ( SB203580 , SP600125 , and curcumin ) , and p38 ( SB203580 and SB202190 ) pathways down-regulated the *stimulated* expression of [MMP-13] . Positive_regulation MMP13 TNF 12878172 1115508 Inhibitors of the transcription factors AP-1 ( nordihydroguaiaretic acid , NDGA ) and NF-kappaB ( curcumin , proteasome inhibitors , and Bay-11-7085 ) suppressed *induced* [MMP-13] expression in primary chondrocytes and SW1353 cells . Positive_regulation MMP13 TNF 12878172 1115509 These results suggest that *induction* of the [MMP-13] gene by is mediated by ERK , p38 , and JNK MAP kinases as well as AP-1 and NF-kappaB transcription factors . Positive_regulation MMP13 TNF 12909329 1121949 *mediates* the stretch induced [MMP] genes expression , at least in part , through the JNK pathway . Positive_regulation MMP13 TNF 14673992 1178630 The in vivo data clearly indicated that OSM + overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP13 TNF 15044327 1272759 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to dependent [MMP] *induction* in the macrophages . Positive_regulation MMP13 TNF 15125014 1244617 In contrast , CMT-5 only inhibited PTH stimulated MMP-13 expression , with no effect on IL-1b or *stimulated* [MMP-13] expression . Positive_regulation MMP13 TNF 15184206 1280575 *causes* increased [MMP] production , but some increased MMP activity is present even in TNFRKO mice . Positive_regulation MMP13 TNF 15201935 1260854 IL-1 and are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP13 TNF 15507443 1347595 [MMP-13] expression *increased* significantly in both CyC-AP-null and wild-type dermal fibroblasts after treatment with IL-1beta or with . Positive_regulation MMP13 TNF 15640153 1381318 In contrast , secretion of [MMP-13] was *stimulated* by but not EGF and was Erk independent and mediated by p38 . Positive_regulation MMP13 TNF 15946654 1421014 We showed that both MMP-1 and [MMP-13] mRNA expression , protein production and enzyme activity *induced* by either IL-1 or were suppressed by t-RA or different retinoid derivatives . Positive_regulation MMP13 TNF 15987479 1429108 MMP-3 and [MMP-13] gene expression *induced* by IL-1beta , and IL-17 was downregulated by mithramycin in human chondrosarcoma SW1353 cells and in primary human and bovine femoral head chondrocytes . Positive_regulation MMP13 TNF 16242974 1508325 *Induction* of [MMP-13] expression by soluble human glucocorticoid induced receptor in fibroblast-like synovial cells . Positive_regulation MMP13 TNF 16549372 1582244 and OSM induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP13 TNF 16549373 1582331 IL-1beta and strongly *induced* the expression of [MMP-1 and -13] in SW1353 cells and HACs , whereas only TNFalpha was found to induce the expression of these two MMPs in JJ012 cells . Positive_regulation MMP13 TNF 17062332 1637225 To investigate the regulatory effects of fenofibrate on *induced* CD40 expression and [matrix metalloproteinase (MMP)] activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation MMP13 TNF 17469134 1737520 OSM and *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP13 TNF 17507431 1791859 Moreover , [MMP] activity in PCPEC supernatants was significantly *increased* by , presumably due to a diminished expression of TIMP-3 that was similarly observed . Positive_regulation MMP13 TNF 17683952 1858104 alpha-MSH inhibits *induced* [matrix metalloproteinase-13] expression by modulating p38 kinase and nuclear factor kappaB signaling in human chondrosarcoma HTB-94 cells . Positive_regulation MMP13 TNF 17683952 1858105 The effect of alpha-MSH on *induced* [MMP-13] expression and mitogen activated protein kinases ' ( MAPKs ) activation were determined by reverse transcriptase-polymerase chain reaction and Western blot analysis . Positive_regulation MMP13 TNF 17683952 1858112 We found that alpha-MSH pretreatment inhibited *induced* [MMP-13] expression and p38 kinase phosphorylation in HTB-94 human chondrosarcoma cells . Positive_regulation MMP13 TNF 17683952 1858113 *induced* [MMP-13] expression was not suppressed by extracellular signal regulated kinase ( ERK ) inhibitors ( PD98059 and U0126 ) or a c-jun terminal kinase ( JNK ) inhibitor ( SP600125 ) , but was inhibited by inhibitors of p38 kinase ( SB203580 ) and NF-kappaB ( SN-50 peptide ) and dnIKKalpha and dnIKKbeta . Positive_regulation MMP13 TNF 17683952 1858116 Our results suggest that alpha-MSH regulates *induced* [MMP-13] expression by decreasing p38 kinase phosphorylation and subsequent NF-kappaB activation in human chondrocytes and may be an effective inhibitor of MMP-13 mediated collagen degradation , providing new potential opportunities for the development of anti-arthritis therapeutics . Positive_regulation MMP13 TNF 17876544 1796346 A similar augmentation was also observed in *induced* cytokine and [MMP] secretion . Positive_regulation MMP13 TNF 19026560 2001510 suppressed collagen type II and aggrecan , but *increased* [MMP] and cytokine expression in chondrocytes compared to the non stimulated controls . Positive_regulation MMP13 TNF 19342682 2056817 However , CD36 transfection in normal human knee immortalized chondrocytes ( CH-8 cells ) was associated with decreased capacity of S100A11 and to *induce* chondrocyte hypertrophy and ADAMTS-4 and [matrix metalloproteinase 13] expression . Positive_regulation MMP13 TNF 19435506 2106973 does not *induce* [MMP] expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation MMP13 TNF 20007453 2210588 We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since *induced* superoxide production , [MMP] expression , and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma . Positive_regulation MMP13 TNF 20403361 2267427 While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha , however , [matrix metalloproteinase (MMP)] *activation* of may also be contributory . Positive_regulation MMP13 TNF 21211511 2391903 Small interfering RNA ( siRNA ) -mediated H-Ras silencing down-regulated [MMP-13] mRNA and protein *induction* by IL-1ß and . Positive_regulation MMP13 TNF 21344384 2480378 15-deoxy-? ( 12,14 ) -prostaglandin-J2 and ciglitazone inhibit *induced* [matrix metalloproteinase 13] production via the antagonism of NF-?B activation in human synovial fibroblasts . Positive_regulation MMP13 TNF 21344384 2480379 Here we found that 15d-PGJ2 and ciglitazone markedly inhibited *induced* [MMP-13] production in human synovial fibroblasts . Positive_regulation MMP13 TNF 21344384 2480380 In addition , activation of nuclear factor ?B ( NF-?B ) is strongly associated with [MMP-13] *induction* by and the activation of NF-?B was determined by Western blot , reporter assay , and immunofluorescence . Positive_regulation MMP13 TNF 21344384 2480381 Ciglitazone also inhibits *induced* [MMP-13] expression by suppressing NF-?B activation mainly via the modulation of p38-MAPK . Positive_regulation MMP13 TNF 21344384 2480396 Collectively , our data demonstrate that 15d-PGJ2 and ciglitazone attenuated *induced* [MMP-13] expression in synovial fibroblasts primarily through the modulation of NF-?B signaling pathways . Positive_regulation MMP13 TNF 22038356 2499447 The result showed that *increased* the expression of ß-catenin and [MMP-13] , and significantly inhibited the synthesis of type II collagen and proteoglycan , which resulted in the degeneration of nucleus pulposus cells . Positive_regulation MMP13 TNF 22038356 2499448 We are led to concluded that could activate the Wnt/ß-catenin signaling pathway , and *increase* the expression of [MMP-13] , thereby resulting in disc degeneration . Positive_regulation MMP13 TNF 23257246 2737293 Resveratrol dose-dependently inhibited *induced* cyclooxygenase-2 (COX-2) , MMP-1 , MMP-3 , [MMP-13] and PGE ( 2 ) production in human chondrocytes . Positive_regulation MMP13 TNF 23370854 2818513 We here investigated the effect of CK ( 0-5 µM ) on *induced* MMP-1 , MMP-3 , and [MMP-13] and TIMP-1 production from RA fibroblast-like synoviocytes ( FLS ) and determined the inhibitory effect of CK on osteoclastogenesis from RAW264.7 cells co-cultured with RA-FLS and from human CD14+ monocytes . Positive_regulation MMP13 TNF 23417988 2843306 SUMO-2/3 was knocked down using small interfering RNA in SFs , and *induced* [MMP] production was determined by ELISA . Positive_regulation MMP13 TNF 23417988 2843339 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by TNF-a and selectively control *mediated* [MMP] expression via the NF-?B pathway . Positive_regulation MMP13 TNF 23603294 2795182 Furthermore , infliximab effectively attenuated the *induced* increases in [MMP] expression in cells that make up the BAB . Positive_regulation MMP13 TNF 7543547 314343 Northern hybridization assays showed pretranslational control of PMA- , basic fibroblast growth factor- , and *induced* [MMP] expression . Positive_regulation MMP13 TNF 9014820 405413 In support of this result , stimulation *induced* membrane-type matrix metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation MMP13 TNF 9558121 500087 Recombinant and IL-1beta added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP13 TNF 9614183 509479 [Collagenase-3] induction in rat lung fibroblasts *requires* the combined effects of and 12-lipoxygenase metabolites : a model of macrophage induced , fibroblast-driven extracellular matrix remodeling during inflammatory lung injury . Positive_regulation MMP13 TNF 9626053 511747 In these cells , [MMP-13] expression at the mRNA and protein level was potently *enhanced* ( up to sixfold ) by , transforming growth factor-beta(1) , and transforming growth factor-alpha and by keratinocyte growth factor in the presence of heparin . Positive_regulation MMP13 TNF 9631748 512565 *increased* the total [MMP] activity released . Positive_regulation MMP13 TNF 9927150 588414 In general , *stimulated* both [MMP] and TIMP expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation MMP13 TNF 9933437 589391 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by IL-1beta and or down-regulated by IFN-gamma . Positive_regulation MMP14 CAPN8 21911754 2496992 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP14 CAPN8 21964156 2525770 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP14 CAPN8 22316244 2553276 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP14 CAPN8 22407449 2587888 Both and vimentin were *required* for successful [MT1-MMP] membrane translocation , which was stimulated by S1P . Positive_regulation MMP14 CTGF 18632843 1979315 In conclusion , upregulation of inhibits BMP-7 signal transduction in the diabetic kidney and *contributes* to altered gene transcription , reduced [MMP] activity , glomerular basement membrane thickening , and albuminuria , all of which are hallmarks of diabetic nephropathy . Positive_regulation MMP14 CTGF 20079746 2218708 These changes were accompanied by evidence of local RAAS activation , increased expression of and TGF-beta1 , and a significant *activation* of MMP-2 and [MT1-MMP] . Positive_regulation MMP14 EPHB2 11684104 875740 Accordingly , [MT1-MMP] overexpression *induced* the activation of , this process being also dependent on the presence of its cytoplasmic domain . Positive_regulation MMP14 EPHB2 14709335 1196646 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP14 EPHB2 14871836 1208291 Expression of a constitutively active form of MEK1 promoted MMP-2 processing concomitant with the increase of MT1-MMP levels , suggesting that [MT1-MMP] is *regulated* by signaling . Positive_regulation MMP14 EPHB2 17348021 1748228 Moreover , the expression of [MMP-3 and -14] , and collagen contraction is partially *prevented* by and Jnk inhibitors . Positive_regulation MMP14 EPHB2 20843518 2353064 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and *dependent* [MMP] expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation MMP14 EPHB2 23166329 2723310 Meanwhile , inhibition of , JNK , and Akt *reduced* the [MT1-MMP] induction . Positive_regulation MMP14 EPHB2 24012928 2862351 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an [MMP] *inhibitor* , or PD98059 ( 50 µM ) , an inhibitor , also suppressed it . Positive_regulation MMP14 IGFBP1 15590975 1346153 Cell numbers were increased only by 100 nM IGFBP-1 isoforms ( P < 0.05 ) , whereas [MMP] levels released from term cells were optimally *increased* by 1-10 nM . Positive_regulation MMP14 IL1B 10207013 606568 Tumor necrosis factor-alpha (TNF-alpha) , interleukin-1alpha , or *caused* a time dependent increase in the steady-state [MT1-MMP] mRNA levels within 4 h of exposure , peaking about 4-fold by 6 h , and remaining elevated for 12 h. Increased MT1-MMP mRNA correlated with a 2.5-fold increase in MT1-MMP protein in EC membranes . Positive_regulation MMP14 IL1B 10727770 678123 and TPA alone *induced* [MMP] activity in HIG-82 cells . Positive_regulation MMP14 IL1B 10864917 705837 and TNF-alpha each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP14 IL1B 10895370 711606 In support of this result , stimulation *induced* the expression of membrane type matrix-metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation MMP14 IL1B 11327259 807578 A decrease in IL-1alpha , , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP14 IL1B 11467889 840797 In all cases , PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on *induction* of [MMP] expression . Positive_regulation MMP14 IL1B 11678909 873740 KE-298 blocked this *induced* pro-MMP-2 activation and [MT1-MMP] expression , but did not affect IL-1beta induced tissue inhibitor of metalloproteinase-2 ( TIMP-2 ) secretion from rheumatoid synovial cells . Positive_regulation MMP14 IL1B 11678909 873742 These findings indicate that activation of rheumatoid synovial cells by *results* in the induction of [MT1-MMP] expression . Positive_regulation MMP14 IL1B 11997239 939296 produced a dose dependent *increase* in [MMP] activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min . Positive_regulation MMP14 IL1B 14872494 1208450 Preincubation with anti-CD44 antibody , which suppressed IL-1beta stimulated MMPs , reversed the inhibitory effect of HA on [MMP] production that was *induced* by in normal and OA cartilage . Positive_regulation MMP14 IL1B 16449361 1573875 HA at > or =2 mg/ml significantly inhibited [MMP] production *induced* by in a dose dependent manner . Positive_regulation MMP14 IL1B 16449361 1573897 Inhibition studies revealed the requirement of NF-kappaB , p38 and c-jun NH2-terminal kinase ( JNK ) for *induced* [MMP] production . Positive_regulation MMP14 IL1B 17328062 1711898 SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on *stimulated* [MMP] production and collagen degradation . Positive_regulation MMP14 IL1B 17925024 1835303 These findings demonstrate , for the first time , that glucosamine inhibits *stimulated* [MMP] production in human chondrocytes by affecting MAPK phosphorylation . Positive_regulation MMP14 IL1B 18403593 1899530 DHA significantly decreased VSMC migration/proliferation *induced* by as well as [fibrinolytic/MMP] activity . Positive_regulation MMP14 IL1B 18535174 1928797 *stimulated* [MMP] mRNA synthesis in wild-type , but not in IL-1RI-null cardiac fibroblasts . Positive_regulation MMP14 IL1B 19056796 2017714 Cordycepin is a potent inhibitor of *induced* chemokine production and [MMP] expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs . Positive_regulation MMP14 IL1B 19542681 2099197 *induced* [MMP] production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ) , p38 kinase , and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase (MAPK) family signal transduction molecules . Positive_regulation MMP14 IL1B 20403707 2282285 *induced* [MMP] production was significantly augmented in the presence of sIL-6R . Positive_regulation MMP14 IL1B 21344389 2480441 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Positive_regulation MMP14 IL1B 22792188 2628382 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation MMP14 IL1B 9558121 500090 Recombinant TNF-alpha and added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP14 IL1B 9821179 548119 The inflammatory cytokine did not *induce* [MMP] or TIMP expression . Positive_regulation MMP14 IL1B 9890433 585416 A beta , but not or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells , as well as *increased* the expression of the well-known activator of MMP-2 , membrane-type ( MT ) [-MMP] . Positive_regulation MMP14 IL1B 9933437 589394 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by and TNF-alpha or down-regulated by IFN-gamma . Positive_regulation MMP14 ITGB2 19728062 2175869 Additionally , blockade significantly *inhibited* the Ang-2/PDGF-BB based increase in matrix metalloproteinase-9 (MMP-9) and [membrane type-1-MMP (MT1-MMP)] . Positive_regulation MMP14 MAP2K6 14871836 1208297 Expression of a constitutively active form of MEK1 promoted MMP-2 processing concomitant with the increase of MT1-MMP levels , suggesting that [MT1-MMP] is *regulated* by signaling . Positive_regulation MMP14 MAP2K6 17348021 1748234 Moreover , the expression of [MMP-3 and -14] , and collagen contraction is partially *prevented* by and Jnk inhibitors . Positive_regulation MMP14 MAP2K6 19833163 2196132 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP14 MAP2K6 20545600 2308426 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP14 MAP2K6 22310287 2718960 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP14 MMP28 10197640 604805 Aggregation of beta1 integrins with immobilized 21C8 or P4C10 antibodies stimulated *dependent* pro-MMP-2 activation and accumulation of a M ( r ) 43,000 form of [membrane type 1 MMP (MT1-MMP)] , a cell surface activator of pro-MMP-2 , in cell extracts . Positive_regulation MMP14 MMP28 10551322 565231 The release of [MT1-MMP] from the Con A-treated cells was *inhibited* by metalloproteinase inhibitors such as EDTA and o-phenanthroline , but not by inhibitors including TIMP-1 , TIMP-2 and BB94 or other proteinase inhibitors of serine , cysteine and aspartic proteinases . Positive_regulation MMP14 MMP28 15247230 1289703 Treatment of oral squamous cell carcinoma cells with TGF-beta1 promoted *dependent* cell scattering and collagen invasion , increased expression of MMP-2 and [MT1-MMP] , and enhanced MMP-2 activation . Positive_regulation MMP14 MMP28 16940349 1609372 Importantly , the expression of also *resulted* in upregulation of [MT1-MMP] and gelatinase-B ( MMP-9 ) and in the collagen invasive activity of A549 cells . Positive_regulation MMP14 MMP7 10197640 604820 Aggregation of beta1 integrins with immobilized 21C8 or P4C10 antibodies stimulated *dependent* pro-MMP-2 activation and accumulation of a M ( r ) 43,000 form of [membrane type 1 MMP (MT1-MMP)] , a cell surface activator of pro-MMP-2 , in cell extracts . Positive_regulation MMP14 MMP7 10551322 565246 The release of [MT1-MMP] from the Con A-treated cells was *inhibited* by metalloproteinase inhibitors such as EDTA and o-phenanthroline , but not by inhibitors including TIMP-1 , TIMP-2 and BB94 or other proteinase inhibitors of serine , cysteine and aspartic proteinases . Positive_regulation MMP14 MMP7 15247230 1289718 Treatment of oral squamous cell carcinoma cells with TGF-beta1 promoted *dependent* cell scattering and collagen invasion , increased expression of MMP-2 and [MT1-MMP] , and enhanced MMP-2 activation . Positive_regulation MMP14 PLAU 9853262 554902 In addition , when the conditioned medium was successively incubated with uPA and alpha 2-macroglobulin and analyzed by immunoblotting , MT1-MMP decreased , indicating that the soluble [MT1-MMP] was in a latent form and was *activated* by . Positive_regulation MMP14 PODXL 17616675 1769333 These findings suggest that leads to increased in vitro migration and invasion , *increased* [MMP] expression , and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MMP14 TGM2 24130925 2714723 Gene silencing of *suppressed* the [MMP] expression by ATRA . Positive_regulation MMP14 TLR7 18802113 1964736 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP14 TNF 10207013 606566 , interleukin-1alpha , or interleukin-1beta *caused* a time dependent increase in the steady-state [MT1-MMP] mRNA levels within 4 h of exposure , peaking about 4-fold by 6 h , and remaining elevated for 12 h. Increased MT1-MMP mRNA correlated with a 2.5-fold increase in MT1-MMP protein in EC membranes . Positive_regulation MMP14 TNF 10482270 643779 We also examined the possibility that such MMPs could be produced by brain derived cells , and that [MMP] production by these cells might be *increased* by , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD . Positive_regulation MMP14 TNF 10864917 705836 IL-1beta and each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP14 TNF 11112697 768053 To investigate this observation at the cellular and molecular levels , we examined *mediated* activation of pro-MMP-2 , induction of [MT1-MMP] , and the intracellular signaling pathways that regulate the proteinase in isolated human dermal fibroblasts . Positive_regulation MMP14 TNF 11112697 768057 We report that significantly *induced* [MT1-MMP] at the mRNA and protein levels when the dermal fibroblasts were grown in collagen . Positive_regulation MMP14 TNF 11147175 760925 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that may *induce* [MMP] production followed by matrix degradation within foreign body granulomas . Positive_regulation MMP14 TNF 11773040 899402 Isolated RMVECs did not significantly increase [MMP] production directly in response to a hypoxic stimulus , but *required* the presence of exogenous . Positive_regulation MMP14 TNF 11773040 899414 *increased* the expression of [MT1-MMP] , MMP-3 , and MMP-9 in these cells . Positive_regulation MMP14 TNF 12113550 963866 Because elevation of COX-2 mRNA levels enhances the production of prostaglandins , we therefore investigated whether endogenous prostaglandins are involved in the [MMP] mRNA expression that is *enhanced* by . Positive_regulation MMP14 TNF 12606436 1064573 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP14 TNF 12909329 1121950 *mediates* the stretch induced [MMP] genes expression , at least in part , through the JNK pathway . Positive_regulation MMP14 TNF 14673992 1178632 The in vivo data clearly indicated that OSM + overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP14 TNF 15044327 1272760 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to dependent [MMP] *induction* in the macrophages . Positive_regulation MMP14 TNF 15184206 1280576 *causes* increased [MMP] production , but some increased MMP activity is present even in TNFRKO mice . Positive_regulation MMP14 TNF 15201935 1260856 IL-1 and are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP14 TNF 16549372 1582246 and OSM induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP14 TNF 17062332 1637226 To investigate the regulatory effects of fenofibrate on *induced* CD40 expression and [matrix metalloproteinase (MMP)] activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation MMP14 TNF 17469134 1737522 OSM and *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP14 TNF 17507431 1791860 Moreover , [MMP] activity in PCPEC supernatants was significantly *increased* by , presumably due to a diminished expression of TIMP-3 that was similarly observed . Positive_regulation MMP14 TNF 17876544 1796347 A similar augmentation was also observed in *induced* cytokine and [MMP] secretion . Positive_regulation MMP14 TNF 17928399 1844114 [MT1-MMP] expression in first-trimester placental tissue is upregulated in type 1 diabetes as a *result* of elevated insulin and levels . Positive_regulation MMP14 TNF 17928399 1844168 The upregulated [MT1-MMP] expression in type 1 diabetes may be the *result* of higher maternal insulin and levels . Positive_regulation MMP14 TNF 18277865 1872182 *induces* MMP2 gelatinase activity and [MT1-MMP] expression in an in vitro model of nucleus pulposus tissue degeneration . Positive_regulation MMP14 TNF 18277865 1872211 Reporter constructs demonstrated that *induced* [MT1-MMP] transcriptional activation and that this response was dependant on ERK MAPK and Egr-1 . Positive_regulation MMP14 TNF 18723334 1984963 In contrast , fibroblasts in areas of parenchymal destruction of emphysema/UIP expressed MMP-2 , MMP-9 , MMP-7 and [MT1-MMP] at variable but significantly higher levels when compared to emphysema subjects , in the *presence* of similar levels of TIMP-1 , TIMP-2 and . Positive_regulation MMP14 TNF 19026560 2001511 suppressed collagen type II and aggrecan , but *increased* [MMP] and cytokine expression in chondrocytes compared to the non stimulated controls . Positive_regulation MMP14 TNF 19435506 2106974 does not *induce* [MMP] expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation MMP14 TNF 20007453 2210589 We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since *induced* superoxide production , [MMP] expression , and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma . Positive_regulation MMP14 TNF 20403361 2267428 While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha , however , [matrix metalloproteinase (MMP)] *activation* of may also be contributory . Positive_regulation MMP14 TNF 23266860 2741452 Induction of [MT1-MMP] expression in *response* to occurs via activation of nuclear factor ( NF ) -?B on inhibitory ?B kinase ( IKK ) activation and subsequently phosphorylation/degradation of I?B-a . Positive_regulation MMP14 TNF 23266860 2741458 Inhibition of PKC-a activity also prevented *induced* [MT1-MMP] expression and proMMP-2 activation as well as down regulation of TIMP-2 expression . Positive_regulation MMP14 TNF 23266860 2741459 Inhibition of I?B-a phosphorylation by PS-1145 , an IKK selective inhibitor , prevented *induced* increase in [MT1-MMP] expression and proMMP-2 activation , which although did not alter inhibition of TIMP-2 expression . Positive_regulation MMP14 TNF 23417988 2843307 SUMO-2/3 was knocked down using small interfering RNA in SFs , and *induced* [MMP] production was determined by ELISA . Positive_regulation MMP14 TNF 23417988 2843340 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by TNF-a and selectively control *mediated* [MMP] expression via the NF-?B pathway . Positive_regulation MMP14 TNF 23603294 2795183 Furthermore , infliximab effectively attenuated the *induced* increases in [MMP] expression in cells that make up the BAB . Positive_regulation MMP14 TNF 7543547 314344 Northern hybridization assays showed pretranslational control of PMA- , basic fibroblast growth factor- , and *induced* [MMP] expression . Positive_regulation MMP14 TNF 9014820 405414 In support of this result , stimulation *induced* membrane-type matrix metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation MMP14 TNF 9558121 500089 Recombinant and IL-1beta added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP14 TNF 9631748 512566 *increased* the total [MMP] activity released . Positive_regulation MMP14 TNF 9927150 588415 In general , *stimulated* both [MMP] and TIMP expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation MMP14 TNF 9933437 589393 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by IL-1beta and or down-regulated by IFN-gamma . Positive_regulation MMP15 CAPN8 21911754 2497006 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP15 CAPN8 21964156 2525784 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP15 CAPN8 22316244 2553290 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP15 CTGF 18632843 1979316 In conclusion , upregulation of inhibits BMP-7 signal transduction in the diabetic kidney and *contributes* to altered gene transcription , reduced [MMP] activity , glomerular basement membrane thickening , and albuminuria , all of which are hallmarks of diabetic nephropathy . Positive_regulation MMP15 EPHB2 14709335 1196648 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP15 EPHB2 20843518 2353065 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and *dependent* [MMP] expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation MMP15 EPHB2 24012928 2862352 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an [MMP] *inhibitor* , or PD98059 ( 50 µM ) , an inhibitor , also suppressed it . Positive_regulation MMP15 IGFBP1 15590975 1346154 Cell numbers were increased only by 100 nM IGFBP-1 isoforms ( P < 0.05 ) , whereas [MMP] levels released from term cells were optimally *increased* by 1-10 nM . Positive_regulation MMP15 IL1B 10727770 678124 and TPA alone *induced* [MMP] activity in HIG-82 cells . Positive_regulation MMP15 IL1B 10864917 705839 and TNF-alpha each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP15 IL1B 10895370 711607 In support of this result , stimulation *induced* the expression of membrane type matrix-metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation MMP15 IL1B 11327259 807581 A decrease in IL-1alpha , , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP15 IL1B 11467889 840798 In all cases , PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on *induction* of [MMP] expression . Positive_regulation MMP15 IL1B 11997239 939297 produced a dose dependent *increase* in [MMP] activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min . Positive_regulation MMP15 IL1B 14872494 1208451 Preincubation with anti-CD44 antibody , which suppressed IL-1beta stimulated MMPs , reversed the inhibitory effect of HA on [MMP] production that was *induced* by in normal and OA cartilage . Positive_regulation MMP15 IL1B 16449361 1573876 HA at > or =2 mg/ml significantly inhibited [MMP] production *induced* by in a dose dependent manner . Positive_regulation MMP15 IL1B 16449361 1573898 Inhibition studies revealed the requirement of NF-kappaB , p38 and c-jun NH2-terminal kinase ( JNK ) for *induced* [MMP] production . Positive_regulation MMP15 IL1B 17328062 1711899 SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on *stimulated* [MMP] production and collagen degradation . Positive_regulation MMP15 IL1B 17925024 1835317 These findings demonstrate , for the first time , that glucosamine inhibits *stimulated* [MMP] production in human chondrocytes by affecting MAPK phosphorylation . Positive_regulation MMP15 IL1B 18403593 1899531 DHA significantly decreased VSMC migration/proliferation *induced* by as well as [fibrinolytic/MMP] activity . Positive_regulation MMP15 IL1B 18535174 1928798 *stimulated* [MMP] mRNA synthesis in wild-type , but not in IL-1RI-null cardiac fibroblasts . Positive_regulation MMP15 IL1B 19056796 2017715 Cordycepin is a potent inhibitor of *induced* chemokine production and [MMP] expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs . Positive_regulation MMP15 IL1B 19542681 2099198 *induced* [MMP] production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ) , p38 kinase , and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase (MAPK) family signal transduction molecules . Positive_regulation MMP15 IL1B 20403707 2282286 *induced* [MMP] production was significantly augmented in the presence of sIL-6R . Positive_regulation MMP15 IL1B 21344389 2480442 These findings establish CEBPB as a critical intermediate for dependent [MMP] gene *activation* and assign specific roles for the ERK and RSK kinases in this pathway . Positive_regulation MMP15 IL1B 22792188 2628383 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation MMP15 IL1B 9558121 500092 Recombinant TNF-alpha and added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP15 IL1B 9821179 548120 The inflammatory cytokine did not *induce* [MMP] or TIMP expression . Positive_regulation MMP15 IL1B 9890433 585417 A beta , but not or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells , as well as *increased* the expression of the well-known activator of MMP-2 , membrane-type ( MT ) [-MMP] . Positive_regulation MMP15 IL1B 9933437 589396 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by and TNF-alpha or down-regulated by IFN-gamma . Positive_regulation MMP15 MAP2K6 19833163 2196139 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP15 MAP2K6 20545600 2308433 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP15 MAP2K6 22310287 2718967 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP15 PODXL 17616675 1769334 These findings suggest that leads to increased in vitro migration and invasion , *increased* [MMP] expression , and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MMP15 TGM2 24130925 2714724 Gene silencing of *suppressed* the [MMP] expression by ATRA . Positive_regulation MMP15 TLR7 18802113 1964746 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP15 TNF 10482270 643780 We also examined the possibility that such MMPs could be produced by brain derived cells , and that [MMP] production by these cells might be *increased* by , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD . Positive_regulation MMP15 TNF 10864917 705838 IL-1beta and each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP15 TNF 11147175 760926 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that may *induce* [MMP] production followed by matrix degradation within foreign body granulomas . Positive_regulation MMP15 TNF 11773040 899403 Isolated RMVECs did not significantly increase [MMP] production directly in response to a hypoxic stimulus , but *required* the presence of exogenous . Positive_regulation MMP15 TNF 12113550 963867 Because elevation of COX-2 mRNA levels enhances the production of prostaglandins , we therefore investigated whether endogenous prostaglandins are involved in the [MMP] mRNA expression that is *enhanced* by . Positive_regulation MMP15 TNF 12606436 1064575 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP15 TNF 12909329 1121951 *mediates* the stretch induced [MMP] genes expression , at least in part , through the JNK pathway . Positive_regulation MMP15 TNF 14673992 1178634 The in vivo data clearly indicated that OSM + overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP15 TNF 15044327 1272761 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to dependent [MMP] *induction* in the macrophages . Positive_regulation MMP15 TNF 15184206 1280577 *causes* increased [MMP] production , but some increased MMP activity is present even in TNFRKO mice . Positive_regulation MMP15 TNF 15201935 1260858 IL-1 and are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP15 TNF 16549372 1582248 and OSM induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP15 TNF 17062332 1637227 To investigate the regulatory effects of fenofibrate on *induced* CD40 expression and [matrix metalloproteinase (MMP)] activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation MMP15 TNF 17469134 1737524 OSM and *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP15 TNF 17507431 1791861 Moreover , [MMP] activity in PCPEC supernatants was significantly *increased* by , presumably due to a diminished expression of TIMP-3 that was similarly observed . Positive_regulation MMP15 TNF 17876544 1796348 A similar augmentation was also observed in *induced* cytokine and [MMP] secretion . Positive_regulation MMP15 TNF 18093301 1839998 The first trimester human trophoblast cell line ACH-3P : a novel tool to study autocrine/paracrine regulatory loops of human trophoblast subpopulations -- *stimulates* [MMP15] expression . Positive_regulation MMP15 TNF 19026560 2001512 suppressed collagen type II and aggrecan , but *increased* [MMP] and cytokine expression in chondrocytes compared to the non stimulated controls . Positive_regulation MMP15 TNF 19435506 2106975 does not *induce* [MMP] expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation MMP15 TNF 20007453 2210590 We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since *induced* superoxide production , [MMP] expression , and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma . Positive_regulation MMP15 TNF 20403361 2267429 While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha , however , [matrix metalloproteinase (MMP)] *activation* of may also be contributory . Positive_regulation MMP15 TNF 23417988 2843308 SUMO-2/3 was knocked down using small interfering RNA in SFs , and *induced* [MMP] production was determined by ELISA . Positive_regulation MMP15 TNF 23417988 2843341 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by TNF-a and selectively control *mediated* [MMP] expression via the NF-?B pathway . Positive_regulation MMP15 TNF 23603294 2795184 Furthermore , infliximab effectively attenuated the *induced* increases in [MMP] expression in cells that make up the BAB . Positive_regulation MMP15 TNF 7543547 314345 Northern hybridization assays showed pretranslational control of PMA- , basic fibroblast growth factor- , and *induced* [MMP] expression . Positive_regulation MMP15 TNF 9014820 405415 In support of this result , stimulation *induced* membrane-type matrix metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation MMP15 TNF 9558121 500091 Recombinant and IL-1beta added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP15 TNF 9631748 512567 *increased* the total [MMP] activity released . Positive_regulation MMP15 TNF 9927150 588416 In general , *stimulated* both [MMP] and TIMP expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation MMP15 TNF 9933437 589395 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by IL-1beta and or down-regulated by IFN-gamma . Positive_regulation MMP16 CAPN8 21911754 2497020 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP16 CAPN8 21964156 2525798 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP16 CAPN8 22316244 2553304 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP16 CTGF 18632843 1979317 In conclusion , upregulation of inhibits BMP-7 signal transduction in the diabetic kidney and *contributes* to altered gene transcription , reduced [MMP] activity , glomerular basement membrane thickening , and albuminuria , all of which are hallmarks of diabetic nephropathy . Positive_regulation MMP16 EPHB2 14709335 1196650 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP16 EPHB2 20843518 2353066 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and *dependent* [MMP] expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation MMP16 EPHB2 24012928 2862353 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an [MMP] *inhibitor* , or PD98059 ( 50 µM ) , an inhibitor , also suppressed it . Positive_regulation MMP16 IGFBP1 15590975 1346155 Cell numbers were increased only by 100 nM IGFBP-1 isoforms ( P < 0.05 ) , whereas [MMP] levels released from term cells were optimally *increased* by 1-10 nM . Positive_regulation MMP16 IL1B 10727770 678125 and TPA alone *induced* [MMP] activity in HIG-82 cells . Positive_regulation MMP16 IL1B 10864917 705841 and TNF-alpha each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP16 IL1B 10895370 711608 In support of this result , stimulation *induced* the expression of membrane type matrix-metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation MMP16 IL1B 11327259 807584 A decrease in IL-1alpha , , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP16 IL1B 11467889 840799 In all cases , PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on *induction* of [MMP] expression . Positive_regulation MMP16 IL1B 11997239 939298 produced a dose dependent *increase* in [MMP] activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min . Positive_regulation MMP16 IL1B 14872494 1208452 Preincubation with anti-CD44 antibody , which suppressed IL-1beta stimulated MMPs , reversed the inhibitory effect of HA on [MMP] production that was *induced* by in normal and OA cartilage . Positive_regulation MMP16 IL1B 16449361 1573877 HA at > or =2 mg/ml significantly inhibited [MMP] production *induced* by in a dose dependent manner . Positive_regulation MMP16 IL1B 16449361 1573899 Inhibition studies revealed the requirement of NF-kappaB , p38 and c-jun NH2-terminal kinase ( JNK ) for *induced* [MMP] production . Positive_regulation MMP16 IL1B 17328062 1711900 SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on *stimulated* [MMP] production and collagen degradation . Positive_regulation MMP16 IL1B 17925024 1835331 These findings demonstrate , for the first time , that glucosamine inhibits *stimulated* [MMP] production in human chondrocytes by affecting MAPK phosphorylation . Positive_regulation MMP16 IL1B 18403593 1899532 DHA significantly decreased VSMC migration/proliferation *induced* by as well as [fibrinolytic/MMP] activity . Positive_regulation MMP16 IL1B 18535174 1928799 *stimulated* [MMP] mRNA synthesis in wild-type , but not in IL-1RI-null cardiac fibroblasts . Positive_regulation MMP16 IL1B 19056796 2017716 Cordycepin is a potent inhibitor of *induced* chemokine production and [MMP] expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs . Positive_regulation MMP16 IL1B 19542681 2099199 *induced* [MMP] production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ) , p38 kinase , and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase (MAPK) family signal transduction molecules . Positive_regulation MMP16 IL1B 20403707 2282287 *induced* [MMP] production was significantly augmented in the presence of sIL-6R . Positive_regulation MMP16 IL1B 21344389 2480443 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Positive_regulation MMP16 IL1B 22792188 2628384 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation MMP16 IL1B 9558121 500094 Recombinant TNF-alpha and added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP16 IL1B 9821179 548121 The inflammatory cytokine did not *induce* [MMP] or TIMP expression . Positive_regulation MMP16 IL1B 9890433 585418 A beta , but not or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells , as well as *increased* the expression of the well-known activator of MMP-2 , membrane-type ( MT ) [-MMP] . Positive_regulation MMP16 IL1B 9933437 589398 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by and TNF-alpha or down-regulated by IFN-gamma . Positive_regulation MMP16 MAP2K6 19833163 2196146 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP16 MAP2K6 20545600 2308440 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP16 MAP2K6 22310287 2718974 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP16 PODXL 17616675 1769335 These findings suggest that leads to increased in vitro migration and invasion , *increased* [MMP] expression , and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MMP16 TGM2 24130925 2714725 Gene silencing of *suppressed* the [MMP] expression by ATRA . Positive_regulation MMP16 TLR7 18802113 1964756 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP16 TNF 10482270 643781 We also examined the possibility that such MMPs could be produced by brain derived cells , and that [MMP] production by these cells might be *increased* by , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD . Positive_regulation MMP16 TNF 10864917 705840 IL-1beta and each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP16 TNF 11147175 760927 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that may *induce* [MMP] production followed by matrix degradation within foreign body granulomas . Positive_regulation MMP16 TNF 11773040 899404 Isolated RMVECs did not significantly increase [MMP] production directly in response to a hypoxic stimulus , but *required* the presence of exogenous . Positive_regulation MMP16 TNF 12113550 963868 Because elevation of COX-2 mRNA levels enhances the production of prostaglandins , we therefore investigated whether endogenous prostaglandins are involved in the [MMP] mRNA expression that is *enhanced* by . Positive_regulation MMP16 TNF 12606436 1064577 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP16 TNF 12909329 1121952 *mediates* the stretch induced [MMP] genes expression , at least in part , through the JNK pathway . Positive_regulation MMP16 TNF 14673992 1178636 The in vivo data clearly indicated that OSM + overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP16 TNF 15044327 1272762 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to dependent [MMP] *induction* in the macrophages . Positive_regulation MMP16 TNF 15184206 1280578 *causes* increased [MMP] production , but some increased MMP activity is present even in TNFRKO mice . Positive_regulation MMP16 TNF 15201935 1260860 IL-1 and are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP16 TNF 16549372 1582250 and OSM induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP16 TNF 17062332 1637228 To investigate the regulatory effects of fenofibrate on *induced* CD40 expression and [matrix metalloproteinase (MMP)] activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation MMP16 TNF 17469134 1737526 OSM and *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP16 TNF 17507431 1791862 Moreover , [MMP] activity in PCPEC supernatants was significantly *increased* by , presumably due to a diminished expression of TIMP-3 that was similarly observed . Positive_regulation MMP16 TNF 17876544 1796349 A similar augmentation was also observed in *induced* cytokine and [MMP] secretion . Positive_regulation MMP16 TNF 19026560 2001513 suppressed collagen type II and aggrecan , but *increased* [MMP] and cytokine expression in chondrocytes compared to the non stimulated controls . Positive_regulation MMP16 TNF 19435506 2106976 does not *induce* [MMP] expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation MMP16 TNF 20007453 2210591 We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since *induced* superoxide production , [MMP] expression , and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma . Positive_regulation MMP16 TNF 20403361 2267430 While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha , however , [matrix metalloproteinase (MMP)] *activation* of may also be contributory . Positive_regulation MMP16 TNF 23417988 2843309 SUMO-2/3 was knocked down using small interfering RNA in SFs , and *induced* [MMP] production was determined by ELISA . Positive_regulation MMP16 TNF 23417988 2843342 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by TNF-a and selectively control *mediated* [MMP] expression via the NF-?B pathway . Positive_regulation MMP16 TNF 23603294 2795185 Furthermore , infliximab effectively attenuated the *induced* increases in [MMP] expression in cells that make up the BAB . Positive_regulation MMP16 TNF 7543547 314346 Northern hybridization assays showed pretranslational control of PMA- , basic fibroblast growth factor- , and *induced* [MMP] expression . Positive_regulation MMP16 TNF 9014820 405416 In support of this result , stimulation *induced* membrane-type matrix metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation MMP16 TNF 9558121 500093 Recombinant and IL-1beta added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP16 TNF 9631748 512568 *increased* the total [MMP] activity released . Positive_regulation MMP16 TNF 9927150 588417 In general , *stimulated* both [MMP] and TIMP expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation MMP16 TNF 9933437 589397 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by IL-1beta and or down-regulated by IFN-gamma . Positive_regulation MMP17 CAPN8 21911754 2497034 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP17 CAPN8 21964156 2525812 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP17 CAPN8 22316244 2553318 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP17 CTGF 18632843 1979318 In conclusion , upregulation of inhibits BMP-7 signal transduction in the diabetic kidney and *contributes* to altered gene transcription , reduced [MMP] activity , glomerular basement membrane thickening , and albuminuria , all of which are hallmarks of diabetic nephropathy . Positive_regulation MMP17 EPHB2 14709335 1196652 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP17 EPHB2 20843518 2353067 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and *dependent* [MMP] expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation MMP17 EPHB2 24012928 2862354 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an [MMP] *inhibitor* , or PD98059 ( 50 µM ) , an inhibitor , also suppressed it . Positive_regulation MMP17 IGFBP1 15590975 1346156 Cell numbers were increased only by 100 nM IGFBP-1 isoforms ( P < 0.05 ) , whereas [MMP] levels released from term cells were optimally *increased* by 1-10 nM . Positive_regulation MMP17 IL1B 10727770 678126 and TPA alone *induced* [MMP] activity in HIG-82 cells . Positive_regulation MMP17 IL1B 10864917 705843 and TNF-alpha each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP17 IL1B 10895370 711609 In support of this result , stimulation *induced* the expression of membrane type matrix-metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation MMP17 IL1B 11327259 807587 A decrease in IL-1alpha , , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP17 IL1B 11467889 840800 In all cases , PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on *induction* of [MMP] expression . Positive_regulation MMP17 IL1B 11997239 939299 produced a dose dependent *increase* in [MMP] activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min . Positive_regulation MMP17 IL1B 14872494 1208453 Preincubation with anti-CD44 antibody , which suppressed IL-1beta stimulated MMPs , reversed the inhibitory effect of HA on [MMP] production that was *induced* by in normal and OA cartilage . Positive_regulation MMP17 IL1B 16449361 1573878 HA at > or =2 mg/ml significantly inhibited [MMP] production *induced* by in a dose dependent manner . Positive_regulation MMP17 IL1B 16449361 1573900 Inhibition studies revealed the requirement of NF-kappaB , p38 and c-jun NH2-terminal kinase ( JNK ) for *induced* [MMP] production . Positive_regulation MMP17 IL1B 17328062 1711901 SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on *stimulated* [MMP] production and collagen degradation . Positive_regulation MMP17 IL1B 17925024 1835345 These findings demonstrate , for the first time , that glucosamine inhibits *stimulated* [MMP] production in human chondrocytes by affecting MAPK phosphorylation . Positive_regulation MMP17 IL1B 18403593 1899533 DHA significantly decreased VSMC migration/proliferation *induced* by as well as [fibrinolytic/MMP] activity . Positive_regulation MMP17 IL1B 18535174 1928800 *stimulated* [MMP] mRNA synthesis in wild-type , but not in IL-1RI-null cardiac fibroblasts . Positive_regulation MMP17 IL1B 19056796 2017717 Cordycepin is a potent inhibitor of *induced* chemokine production and [MMP] expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs . Positive_regulation MMP17 IL1B 19542681 2099200 *induced* [MMP] production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ) , p38 kinase , and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase (MAPK) family signal transduction molecules . Positive_regulation MMP17 IL1B 20403707 2282288 *induced* [MMP] production was significantly augmented in the presence of sIL-6R . Positive_regulation MMP17 IL1B 21344389 2480444 These findings establish CEBPB as a critical intermediate for dependent [MMP] gene *activation* and assign specific roles for the ERK and RSK kinases in this pathway . Positive_regulation MMP17 IL1B 22792188 2628385 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation MMP17 IL1B 9558121 500096 Recombinant TNF-alpha and added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP17 IL1B 9821179 548122 The inflammatory cytokine did not *induce* [MMP] or TIMP expression . Positive_regulation MMP17 IL1B 9890433 585419 A beta , but not or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells , as well as *increased* the expression of the well-known activator of MMP-2 , membrane-type ( MT ) [-MMP] . Positive_regulation MMP17 IL1B 9933437 589400 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by and TNF-alpha or down-regulated by IFN-gamma . Positive_regulation MMP17 MAP2K6 19833163 2196153 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP17 MAP2K6 20545600 2308447 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP17 MAP2K6 22310287 2718981 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP17 PODXL 17616675 1769336 These findings suggest that leads to increased in vitro migration and invasion , *increased* [MMP] expression , and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MMP17 TGM2 24130925 2714726 Gene silencing of *suppressed* the [MMP] expression by ATRA . Positive_regulation MMP17 TLR7 18802113 1964766 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP17 TNF 10482270 643782 We also examined the possibility that such MMPs could be produced by brain derived cells , and that [MMP] production by these cells might be *increased* by , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD . Positive_regulation MMP17 TNF 10864917 705842 IL-1beta and each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP17 TNF 11147175 760928 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that may *induce* [MMP] production followed by matrix degradation within foreign body granulomas . Positive_regulation MMP17 TNF 11773040 899405 Isolated RMVECs did not significantly increase [MMP] production directly in response to a hypoxic stimulus , but *required* the presence of exogenous . Positive_regulation MMP17 TNF 12113550 963869 Because elevation of COX-2 mRNA levels enhances the production of prostaglandins , we therefore investigated whether endogenous prostaglandins are involved in the [MMP] mRNA expression that is *enhanced* by . Positive_regulation MMP17 TNF 12606436 1064579 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP17 TNF 12909329 1121953 *mediates* the stretch induced [MMP] genes expression , at least in part , through the JNK pathway . Positive_regulation MMP17 TNF 12962706 1138531 Stimulation of eosinophils with *increased* [MT4-MMP] mRNA expression . Positive_regulation MMP17 TNF 12962706 1138532 *increased* expression of the [MT4-MMP] protein . Positive_regulation MMP17 TNF 14673992 1178638 The in vivo data clearly indicated that OSM + overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP17 TNF 15044327 1272763 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to dependent [MMP] *induction* in the macrophages . Positive_regulation MMP17 TNF 15184206 1280579 *causes* increased [MMP] production , but some increased MMP activity is present even in TNFRKO mice . Positive_regulation MMP17 TNF 15201935 1260862 IL-1 and are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP17 TNF 16549372 1582252 and OSM induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP17 TNF 17062332 1637229 To investigate the regulatory effects of fenofibrate on *induced* CD40 expression and [matrix metalloproteinase (MMP)] activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation MMP17 TNF 17469134 1737528 OSM and *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP17 TNF 17507431 1791863 Moreover , [MMP] activity in PCPEC supernatants was significantly *increased* by , presumably due to a diminished expression of TIMP-3 that was similarly observed . Positive_regulation MMP17 TNF 17876544 1796350 A similar augmentation was also observed in *induced* cytokine and [MMP] secretion . Positive_regulation MMP17 TNF 19026560 2001514 suppressed collagen type II and aggrecan , but *increased* [MMP] and cytokine expression in chondrocytes compared to the non stimulated controls . Positive_regulation MMP17 TNF 19435506 2106977 does not *induce* [MMP] expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation MMP17 TNF 20007453 2210592 We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since *induced* superoxide production , [MMP] expression , and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma . Positive_regulation MMP17 TNF 20403361 2267431 While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha , however , [matrix metalloproteinase (MMP)] *activation* of may also be contributory . Positive_regulation MMP17 TNF 23417988 2843310 SUMO-2/3 was knocked down using small interfering RNA in SFs , and *induced* [MMP] production was determined by ELISA . Positive_regulation MMP17 TNF 23417988 2843343 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by TNF-a and selectively control *mediated* [MMP] expression via the NF-?B pathway . Positive_regulation MMP17 TNF 23603294 2795186 Furthermore , infliximab effectively attenuated the *induced* increases in [MMP] expression in cells that make up the BAB . Positive_regulation MMP17 TNF 7543547 314347 Northern hybridization assays showed pretranslational control of PMA- , basic fibroblast growth factor- , and *induced* [MMP] expression . Positive_regulation MMP17 TNF 9014820 405417 In support of this result , stimulation *induced* membrane-type matrix metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation MMP17 TNF 9558121 500095 Recombinant and IL-1beta added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP17 TNF 9631748 512569 *increased* the total [MMP] activity released . Positive_regulation MMP17 TNF 9927150 588418 In general , *stimulated* both [MMP] and TIMP expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation MMP17 TNF 9933437 589399 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by IL-1beta and or down-regulated by IFN-gamma . Positive_regulation MMP19 CAPN8 21911754 2497048 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP19 CAPN8 21964156 2525826 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP19 CAPN8 22316244 2553332 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP19 CTGF 18632843 1979319 In conclusion , upregulation of inhibits BMP-7 signal transduction in the diabetic kidney and *contributes* to altered gene transcription , reduced [MMP] activity , glomerular basement membrane thickening , and albuminuria , all of which are hallmarks of diabetic nephropathy . Positive_regulation MMP19 EPHB2 14709335 1196654 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP19 EPHB2 20843518 2353068 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and *dependent* [MMP] expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation MMP19 EPHB2 24012928 2862355 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an [MMP] *inhibitor* , or PD98059 ( 50 µM ) , an inhibitor , also suppressed it . Positive_regulation MMP19 IGFBP1 15590975 1346157 Cell numbers were increased only by 100 nM IGFBP-1 isoforms ( P < 0.05 ) , whereas [MMP] levels released from term cells were optimally *increased* by 1-10 nM . Positive_regulation MMP19 IL1B 10727770 678127 and TPA alone *induced* [MMP] activity in HIG-82 cells . Positive_regulation MMP19 IL1B 10864917 705845 and TNF-alpha each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP19 IL1B 10895370 711610 In support of this result , stimulation *induced* the expression of membrane type matrix-metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation MMP19 IL1B 11327259 807590 A decrease in IL-1alpha , , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP19 IL1B 11467889 840801 In all cases , PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on *induction* of [MMP] expression . Positive_regulation MMP19 IL1B 11997239 939300 produced a dose dependent *increase* in [MMP] activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min . Positive_regulation MMP19 IL1B 14872494 1208454 Preincubation with anti-CD44 antibody , which suppressed IL-1beta stimulated MMPs , reversed the inhibitory effect of HA on [MMP] production that was *induced* by in normal and OA cartilage . Positive_regulation MMP19 IL1B 16449361 1573879 HA at > or =2 mg/ml significantly inhibited [MMP] production *induced* by in a dose dependent manner . Positive_regulation MMP19 IL1B 16449361 1573901 Inhibition studies revealed the requirement of NF-kappaB , p38 and c-jun NH2-terminal kinase ( JNK ) for *induced* [MMP] production . Positive_regulation MMP19 IL1B 17328062 1711902 SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on *stimulated* [MMP] production and collagen degradation . Positive_regulation MMP19 IL1B 17925024 1835359 These findings demonstrate , for the first time , that glucosamine inhibits *stimulated* [MMP] production in human chondrocytes by affecting MAPK phosphorylation . Positive_regulation MMP19 IL1B 18403593 1899534 DHA significantly decreased VSMC migration/proliferation *induced* by as well as [fibrinolytic/MMP] activity . Positive_regulation MMP19 IL1B 18535174 1928801 *stimulated* [MMP] mRNA synthesis in wild-type , but not in IL-1RI-null cardiac fibroblasts . Positive_regulation MMP19 IL1B 19056796 2017718 Cordycepin is a potent inhibitor of *induced* chemokine production and [MMP] expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs . Positive_regulation MMP19 IL1B 19542681 2099201 *induced* [MMP] production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ) , p38 kinase , and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase (MAPK) family signal transduction molecules . Positive_regulation MMP19 IL1B 20403707 2282289 *induced* [MMP] production was significantly augmented in the presence of sIL-6R . Positive_regulation MMP19 IL1B 21344389 2480445 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Positive_regulation MMP19 IL1B 22792188 2628386 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation MMP19 IL1B 9558121 500098 Recombinant TNF-alpha and added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP19 IL1B 9821179 548123 The inflammatory cytokine did not *induce* [MMP] or TIMP expression . Positive_regulation MMP19 IL1B 9890433 585420 A beta , but not or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells , as well as *increased* the expression of the well-known activator of MMP-2 , membrane-type ( MT ) [-MMP] . Positive_regulation MMP19 IL1B 9933437 589402 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by and TNF-alpha or down-regulated by IFN-gamma . Positive_regulation MMP19 MAP2K6 14708598 1181113 Activation of p38 alone by adenovirally delivered constitutively active MAPK kinase 3b (MKK3b) and also *enhanced* [MMP-19] production , and the most potent induction of MMP-19 expression was noted when ERK1/2 was activated in combination with p38 . Positive_regulation MMP19 MAP2K6 19833163 2196160 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP19 MAP2K6 20545600 2308454 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP19 MAP2K6 22310287 2718988 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP19 PODXL 17616675 1769337 These findings suggest that leads to increased in vitro migration and invasion , *increased* [MMP] expression , and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MMP19 TGM2 24130925 2714727 Gene silencing of *suppressed* the [MMP] expression by ATRA . Positive_regulation MMP19 TLR7 18802113 1964776 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP19 TNF 10482270 643783 We also examined the possibility that such MMPs could be produced by brain derived cells , and that [MMP] production by these cells might be *increased* by , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD . Positive_regulation MMP19 TNF 10864917 705844 IL-1beta and each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP19 TNF 11147175 760929 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that may *induce* [MMP] production followed by matrix degradation within foreign body granulomas . Positive_regulation MMP19 TNF 11773040 899406 Isolated RMVECs did not significantly increase [MMP] production directly in response to a hypoxic stimulus , but *required* the presence of exogenous . Positive_regulation MMP19 TNF 12113550 963870 Because elevation of COX-2 mRNA levels enhances the production of prostaglandins , we therefore investigated whether endogenous prostaglandins are involved in the [MMP] mRNA expression that is *enhanced* by . Positive_regulation MMP19 TNF 12606436 1064581 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP19 TNF 12909329 1121954 *mediates* the stretch induced [MMP] genes expression , at least in part , through the JNK pathway . Positive_regulation MMP19 TNF 14673992 1178640 The in vivo data clearly indicated that OSM + overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP19 TNF 14708598 1181078 [MMP-19] mRNA expression and pro-MMP-19 production by dermal fibroblasts in culture was potently *enhanced* by . Positive_regulation MMP19 TNF 14708598 1181079 *Induction* of [MMP-19] expression by was prevented partially by blocking the activation of extracellular signal regulated kinase ( ERK ) -1/2 by PD98059 and p38 activity by SB203580 . Positive_regulation MMP19 TNF 15044327 1272764 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to dependent [MMP] *induction* in the macrophages . Positive_regulation MMP19 TNF 15184206 1280580 *causes* increased [MMP] production , but some increased MMP activity is present even in TNFRKO mice . Positive_regulation MMP19 TNF 15201935 1260864 IL-1 and are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP19 TNF 16549372 1582254 and OSM induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP19 TNF 17062332 1637230 To investigate the regulatory effects of fenofibrate on *induced* CD40 expression and [matrix metalloproteinase (MMP)] activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation MMP19 TNF 17469134 1737530 OSM and *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP19 TNF 17507431 1791864 Moreover , [MMP] activity in PCPEC supernatants was significantly *increased* by , presumably due to a diminished expression of TIMP-3 that was similarly observed . Positive_regulation MMP19 TNF 17876544 1796351 A similar augmentation was also observed in *induced* cytokine and [MMP] secretion . Positive_regulation MMP19 TNF 19026560 2001515 suppressed collagen type II and aggrecan , but *increased* [MMP] and cytokine expression in chondrocytes compared to the non stimulated controls . Positive_regulation MMP19 TNF 19435506 2106978 does not *induce* [MMP] expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation MMP19 TNF 20007453 2210593 We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since *induced* superoxide production , [MMP] expression , and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma . Positive_regulation MMP19 TNF 20403361 2267432 While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha , however , [matrix metalloproteinase (MMP)] *activation* of may also be contributory . Positive_regulation MMP19 TNF 21067565 2354686 In U251 and U373 cells expression of MMP-9 and [MMP-19] was *stimulated* by . Positive_regulation MMP19 TNF 23417988 2843311 SUMO-2/3 was knocked down using small interfering RNA in SFs , and *induced* [MMP] production was determined by ELISA . Positive_regulation MMP19 TNF 23417988 2843344 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by TNF-a and selectively control *mediated* [MMP] expression via the NF-?B pathway . Positive_regulation MMP19 TNF 23603294 2795187 Furthermore , infliximab effectively attenuated the *induced* increases in [MMP] expression in cells that make up the BAB . Positive_regulation MMP19 TNF 7543547 314348 Northern hybridization assays showed pretranslational control of PMA- , basic fibroblast growth factor- , and *induced* [MMP] expression . Positive_regulation MMP19 TNF 9014820 405418 In support of this result , stimulation *induced* membrane-type matrix metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation MMP19 TNF 9558121 500097 Recombinant and IL-1beta added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP19 TNF 9631748 512570 *increased* the total [MMP] activity released . Positive_regulation MMP19 TNF 9927150 588419 In general , *stimulated* both [MMP] and TIMP expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation MMP19 TNF 9933437 589401 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by IL-1beta and or down-regulated by IFN-gamma . Positive_regulation MMP2 ALOX5 12173047 974411 The generation of [MMP2] is *mediated* by activation of phospholipase A(2) and <5-lipoxygenase> . Positive_regulation MMP2 ALOX5 19586628 2194859 Thus , this study investigated the *role* of <5-LO> in HNE enhanced [MMP-2] production in VSMC , and the mechanisms by which this enzyme could be activated by HNE . Positive_regulation MMP2 ALOX5 19586628 2194862 Collectively , these data suggest that <5-LO> *mediates* HNE enhanced [MMP-2] production via LTB ( 4 ) -BLT receptor pathways , consequently leading to atherosclerotic plaque instability . Positive_regulation MMP2 ANGPT1 10807867 692378 *induced* the secretion of plasmin and [matrix metalloproteinase-2 (MMP-2)] , which is inhibited by PI 3'-kinase inhibitors . Positive_regulation MMP2 ANGPT1 11116055 757973 or VEGF induced migration and sprouting activity , *increased* plasmin and [matrix metalloproteinase-2] secretion , and decreased tissue inhibitors of metalloproteinase type 2 secretion . Positive_regulation MMP2 CAPN8 21911754 2497062 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP2 CAPN8 21964156 2525840 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP2 CAPN8 22316244 2553346 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP2 CLDN10 11382769 835104 These results suggest that recruits all MT-MMPs and pro-MMP-2 on the cell surface to achieve elevated focal concentrations and , consequently , *enhances* activation of [pro-MMP-2] . Positive_regulation MMP2 CTGF 11773059 916281 We found that the over-expression of significantly *increased* the activity of [MMP-2] in VSMC conditioned medium . Positive_regulation MMP2 CTGF 11773059 916282 We further studied the mechanisms involved in the regulation of MMP-2 mRNA levels and found that the AP-2 transcription factor is responsible for most of the *induced* [MMP-2] transcription . Positive_regulation MMP2 CTGF 15144592 1247592 While cells were stimulated for 48 hours , 100 ng/ml and 5 ng/ml TGF- beta(1) induce a *increase* in [MMP-2] activity and protein levels compared with vechile , respectively ( P < 0.05 ) ; Positive_regulation MMP2 CTGF 18028129 1827917 increases matrix metalloproteinase-2 and *suppresses* tissue inhibitor of [matrix metalloproteinase-2] production by cultured renal interstitial fibroblasts . Positive_regulation MMP2 CTGF 18028129 1827918 We found that significantly *increased* the activity of MMP-2 , as well as [MMP-2] protein in conditioned medium and MMP-2 mRNA levels in cells . Positive_regulation MMP2 CTGF 18028129 1827919 Further studies showed that extracellular signal regulated kinase ( ERK ) signaling is responsible for most of the *induced* [MMP-2] expression and TIMP-2 suppression . Positive_regulation MMP2 CTGF 18028129 1827920 Suppression of ERK1/2 activation with nontoxic concentrations of PD98059 , a specific inhibitor of ERK activation , was associated with a reduction of *stimulated* [MMP-2] activity and protein expression . Positive_regulation MMP2 CTGF 18632843 1979320 In conclusion , upregulation of inhibits BMP-7 signal transduction in the diabetic kidney and *contributes* to altered gene transcription , reduced [MMP] activity , glomerular basement membrane thickening , and albuminuria , all of which are hallmarks of diabetic nephropathy . Positive_regulation MMP2 CTGF 19011018 2047242 Using zymography , *increased* the latent and active forms of [MMP-2] compared to controls ( P=0.02 ) . Positive_regulation MMP2 CTGF 19276073 2072862 *increased* fibronectin (FN) amount , [MMP-2] mRNA expression , and gelatinase activity in 3T3 cells . Positive_regulation MMP2 CTGF 19301817 2056139 The proliferation signal mediated by high glucose was demonstrated via CTGF/RAGE , while [MMP-2] was *regulated* by but not RAGE . Positive_regulation MMP2 CTGF 20079746 2218710 These changes were accompanied by evidence of local RAAS activation , increased expression of and TGF-beta1 , and a significant *activation* of [MMP-2] and MT1-MMP . Positive_regulation MMP2 CTGF 23048035 2702758 In cultured cells , *activated* the [MMP-2] promoter through increased expression and tethering of the p53 transcription factor to a highly conserved p53 binding sequence within the MMP-2 promoter . Positive_regulation MMP2 CTGF 23550216 2767183 Preincubation of ARPE-19 with Y27632 ( 10mmol/L ) significantly prevented or TGF- ß *induced* fibronectin ( P=0.005 , P=0.003 respectively ) , [MMP-2] ( P= 0.003 , P=0.002 ) , COL1A1 ( P=0.006 , P=0.003 ) , and COL1A2 ( P=0.006 , P=0.004 ) gene expression , but not laminin ( P=0.375 , P=0.516 ) . Positive_regulation MMP2 EPHB2 12087091 976461 Collectively , our data suggest that NSAIDs *inhibit* [MMP-2] by blocking mediated transcription . Positive_regulation MMP2 EPHB2 14559821 1153839 Taken together , our results strongly suggest that SHP-2 plays a critical role as a positive mediator for Con A-dependent *activation* of [MMP-2] secretion via and Ras-p38 signalings . Positive_regulation MMP2 EPHB2 14709335 1196656 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP2 EPHB2 15492268 1321509 These results suggest that PGE ( 2 ) mediates pancreatic cancer cellular invasiveness through an *dependent* induction of [MMP-2] expression and activity . Positive_regulation MMP2 EPHB2 15713899 1374034 inhibitor ( PD98059 ) and PKC inhibitors ( GF-109203X and H-7 ) , but not p38 inhibitor ( SB203580 ) or c-jun-NH2-kinase inhibitor ( SP600125 ) , significantly *inhibited* TPA induced [MMP-2] protein expression , with reduced ERK phosphorylation and c-Jun protein expression . Positive_regulation MMP2 EPHB2 19061309 2017987 The results suggest that I3C *inhibits* [MMP-2] expression by blocking the mediated gene transcription to attenuate migration and invasion of breast cancer cells . Positive_regulation MMP2 EPHB2 19326946 2074123 Furthermore , the inhibitor ( U0126 ) could *result* in reduced activities of [MMP-2] and u-PA concomitantly with a marked inhibition on cell invasion and migration . Positive_regulation MMP2 EPHB2 20843518 2353069 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and *dependent* [MMP] expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation MMP2 EPHB2 21126656 2355808 Both SBT and LBT upregulate [MMP-2] expression , and LBT induced MMP-2 expression might be *mediated* by phosphoinositide 3-kinase , p38 mitogen activated protein kinase , c-Jun N-terminal kinase , and nuclear factor-?B , and to a lesser extent , by reactive oxygen species , rather than by . Positive_regulation MMP2 EPHB2 21885032 2524499 PERIOSTIN treatment also induced ERK phosphorylation , and PERIOSTIN induced [MMP-2] was *reduced* by avß3 integrin blocking antibody or inhibitor . Positive_regulation MMP2 EPHB2 23166329 2723306 inhibition of and Akt effectively *reduced* [MMP-2] induction by hHK-1 . Positive_regulation MMP2 EPHB2 23306155 2746517 Derlin-1 is overexpressed in non-small cell lung cancer and promotes cancer cell invasion via *mediated* up-regulation of [MMP-2] and MMP-9 . Positive_regulation MMP2 EPHB2 23306155 2746531 In summary , our results showed that Derlin-1 is overexpressed in NSCLC and promotes invasion by *mediated* up-regulation of [MMP-2] and MMP-9 . Positive_regulation MMP2 EPHB2 23503466 2915707 Inhibition of with a pharmacological inhibitor or small interfering RNAs ( siRNAs ) markedly *suppressed* the radiation induced tube formation and [MMP-2] upregulation in NECs , whereas the inhibition of either AKT or JNK with pharmacological inhibitor or siRNA treatment of CECs markedly attenuated the inhibition of tube formation and the upregulation of angiostatin and IL-6 caused by 4 Gy irradiation . Positive_regulation MMP2 EPHB2 24012928 2862356 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an [MMP] *inhibitor* , or PD98059 ( 50 µM ) , an inhibitor , also suppressed it . Positive_regulation MMP2 FOXO1 16077930 1442439 Exogenous expression of the ARMS specific chimeric protein in RD cells *increased* [MMP-2] activity and invasiveness . Positive_regulation MMP2 FOXO1 16077930 1442446 Overall , our data suggest that a high level of MMP-2 protein and VEGF/VEGFR expression may contribute to the metastatic phenotype of ARMS cells and that exogenously induced expression *increases* [MMP-2] secretion and invasive capability of RMS cells . Positive_regulation MMP2 FOXO1 19675556 2119685 Furthermore , *induced* opposite changes in COLIAI , MMP-1 , and [MMP-2] expression . Positive_regulation MMP2 HBEGF 18852147 1977069 The reduction of expression *attenuated* the chemotactic invasive ability and the expression of [matrix metalloprotease (MMP)-2] and vascular endothelial growth factor ( VEGF ) , leading to the inhibition of cell invasion and angiogenesis . Positive_regulation MMP2 ID1 21467165 2428094 Moreover , we showed that MUC18 promotes melanoma invasion through Id-1 , as overexpression of in MUC18 silenced cells *resulted* in increased [MMP-2] expression and activity . Positive_regulation MMP2 ID1 23714001 2801678 shRNA mediated down-regulation substantially *reduced* EPC angiogenesis and [MMP-2] expression . Positive_regulation MMP2 IGFBP1 15590975 1346158 Cell numbers were increased only by 100 nM IGFBP-1 isoforms ( P < 0.05 ) , whereas [MMP] levels released from term cells were optimally *increased* by 1-10 nM . Positive_regulation MMP2 IL1B 10727770 678128 and TPA alone *induced* [MMP] activity in HIG-82 cells . Positive_regulation MMP2 IL1B 10864917 705847 and TNF-alpha each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP2 IL1B 10895370 711573 however , stimulation *induced* the secretion of [MMP-2] as an active form from rheumatoid osteoblasts . Positive_regulation MMP2 IL1B 10895370 711611 In support of this result , stimulation *induced* the expression of membrane type matrix-metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation MMP2 IL1B 10895370 711619 These results suggest that *induces* [MMP-2] activation in part by up-regulating MT-MMP expression and represents a new mechanism for cytokine mediated articular destruction in RA . Positive_regulation MMP2 IL1B 11052827 743479 The [MMP-2] activities of the three cell lines were significantly increased in the *presence* of and IL-6 , but no modulation of MMP-2 activities was observed in the presence of OSM , LIF and GH . Positive_regulation MMP2 IL1B 11327259 807593 A decrease in IL-1alpha , , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP2 IL1B 11467889 840802 In all cases , PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on *induction* of [MMP] expression . Positive_regulation MMP2 IL1B 11480246 843588 TNF-alpha and *induced* increases in the concentrations of MMP-1 , MMP-3 , and MMP-9 , but not in [MMP-2] or tissue inhibitor of matrix metalloproteinase ( TIMP ) -1 or -2 . Positive_regulation MMP2 IL1B 11678909 873741 KE-298 blocked this induced [pro-MMP-2] *activation* and MT1-MMP expression , but did not affect IL-1beta induced tissue inhibitor of metalloproteinase-2 ( TIMP-2 ) secretion from rheumatoid synovial cells . Positive_regulation MMP2 IL1B 11811504 892761 As anticipated , *induced* a marked release of [MMP-2] , MMP-3 , and TIMP-1 , but no variation for TIMP-2 was seen . Positive_regulation MMP2 IL1B 11997239 939301 produced a dose dependent *increase* in [MMP] activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min . Positive_regulation MMP2 IL1B 14612199 1162859 Stimulation of cultured human aortic valve myofibroblasts with *lead* to a time-dependently increased expression of MMP-1 and [MMP-2] by Western blotting and zymography , whereas MMP-9 remained unchanged . Positive_regulation MMP2 IL1B 14872494 1208455 Preincubation with anti-CD44 antibody , which suppressed IL-1beta stimulated MMPs , reversed the inhibitory effect of HA on [MMP] production that was *induced* by in normal and OA cartilage . Positive_regulation MMP2 IL1B 15269222 1290328 , which is increased in the heart following myocardial infarction , *increases* expression and activity of [MMP-2] ( gelatinase A ) and -9 ( gelatinase B ) in cardiac fibroblasts . Positive_regulation MMP2 IL1B 15269222 1290333 Inhibition of PKC-theta and PKC-zeta using pseudosubstrates inhibited *stimulated* activation of ERK1/2 and JNKs and the expression and activity of [MMP-2] and -9 . Positive_regulation MMP2 IL1B 15269222 1290337 SN50 , NF-kappaB inhibitor peptide , inhibited *stimulated* increases in [MMP-2] and -9 expression and activity . Positive_regulation MMP2 IL1B 15860218 1400799 FK506 had no detectable effects on *induced* [MMP-2] induction . Positive_regulation MMP2 IL1B 16273295 1479672 IL-1alpha and *promoted* MMP-1 but not [MMP-2] production in UVA irradiated fibroblasts . Positive_regulation MMP2 IL1B 16364234 1504736 This fucoidan is able to inhibit [gelatinase A] secretion and stromelysin 1 *induction* by on dermal fibroblasts in culture . Positive_regulation MMP2 IL1B 16449361 1573880 HA at > or =2 mg/ml significantly inhibited [MMP] production *induced* by in a dose dependent manner . Positive_regulation MMP2 IL1B 16449361 1573902 Inhibition studies revealed the requirement of NF-kappaB , p38 and c-jun NH2-terminal kinase ( JNK ) for *induced* [MMP] production . Positive_regulation MMP2 IL1B 16522689 1567944 *stimulated* MMP-1 ( 5.6-fold ) , [MMP-2] ( 2.8-fold ) , and MMP-3 ( 75-fold ) gene expression , but not EMMPRIN , over levels in control cells ( P < 0.05 ) . Positive_regulation MMP2 IL1B 16869002 1607355 Regulation of *induced* chemokine production and [matrix metalloproteinase 2] activation by epigallocatechin-3-gallate in rheumatoid arthritis synovial fibroblasts . Positive_regulation MMP2 IL1B 16934628 1608838 TNF-alpha , , and IL-6 *increased* the mRNA and/or protein expression of MMP-1 , [MMP-2] , and MMP-3 . Positive_regulation MMP2 IL1B 16987994 1692463 RT-PCR and Western blot analyses confirmed increased expression of [MMP-2] in *response* to . Positive_regulation MMP2 IL1B 16987994 1692470 IL-1beta activated ERK1/2 , JNKs , and protein kinase C ( PKC ) , specifically PKCalpha/beta ( 1 ) , and inhibition of these cascades partially inhibited *stimulated* increases in [MMP-2] . Positive_regulation MMP2 IL1B 16987994 1692471 However , concurrent inhibition of PKCalpha/beta ( 1 ) and ERK1/2 almost completely inhibited *mediated* increases in [MMP-2] expression . Positive_regulation MMP2 IL1B 16987994 1692474 Pretreatment with superoxide dismutase (SOD) mimetic , MnTMPyP , increased MMP-2 protein levels , whereas pretreatment with SOD and catalase mimetic , EUK134 , partially inhibited *stimulated* increases in [MMP-2] protein levels . Positive_regulation MMP2 IL1B 17328062 1711903 SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on *stimulated* [MMP] production and collagen degradation . Positive_regulation MMP2 IL1B 17706606 1789077 *increased* release of [MMP-2] , -3 , and -9 , and TIMP-1 , by 3-6-fold , measured by immunoblotting and gel zymography . Positive_regulation MMP2 IL1B 17925024 1835373 These findings demonstrate , for the first time , that glucosamine inhibits *stimulated* [MMP] production in human chondrocytes by affecting MAPK phosphorylation . Positive_regulation MMP2 IL1B 18192036 1903394 Using gelatin zymography and RT-PCR and Griess analysis , we found that *increased* the [MMP-2] activity and transcription and nitric oxide ( NO ) production from supernatant of culture medium . Positive_regulation MMP2 IL1B 18192036 1903395 The current study demonstrates imidaprilat inhibits [MMP-2] activity and expression in human cardiac fibroblasts *induced* by via NO-dependent pathway . Positive_regulation MMP2 IL1B 18276934 1911669 Similarly , quantitative RT-PCR found that TNF and *enhanced* MMP9 , but not [MMP2] , mRNA levels . Positive_regulation MMP2 IL1B 18403593 1899535 DHA significantly decreased VSMC migration/proliferation *induced* by as well as [fibrinolytic/MMP] activity . Positive_regulation MMP2 IL1B 18434122 1926382 Neither nor TNF-alpha treated SV40-T2 cells *increased* the secretion of MMP-9 and [MMP-2] . Positive_regulation MMP2 IL1B 18535174 1928802 *stimulated* [MMP] mRNA synthesis in wild-type , but not in IL-1RI-null cardiac fibroblasts . Positive_regulation MMP2 IL1B 18570937 1930039 RT-PCR analyses revealed membrane type 1 (MT1)-MMP mRNA levels , not [MMP-2] or tissue inhibitor of MMP (TIMP) , were significantly *increased* by , and Western blot analyses confirmed a significant increase in MT1-MMP protein in response to Est alone . Positive_regulation MMP2 IL1B 18676628 1979505 TPCA-1 inhibited the IL-1beta induced expression of MMP-1 , -3 , and -9 in these cells at both the mRNA and protein levels and the *induced* activation of [pro-MMP-2] . Positive_regulation MMP2 IL1B 18950946 2041299 Our results showed that ( 10 ng/ml ) *stimulated* a statistically significant increase in MCP-1 and [MMP-2] production and decreased production of TIMP-2 by both normal and keloid derived fibroblasts ( Student 's t-test , p < 0.05 ) , but to differing extents . Positive_regulation MMP2 IL1B 19056796 2017719 Cordycepin is a potent inhibitor of *induced* chemokine production and [MMP] expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs . Positive_regulation MMP2 IL1B 19427585 2076793 It was found that *induced* the activity of [MMP-2] and MMP-9 during the 48 h time course of the experiment , especially after 24h incubation , while DETA/NO , donor of NO , stimulated the process at 12h incubation . Positive_regulation MMP2 IL1B 19542681 2099202 *induced* [MMP] production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ) , p38 kinase , and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase (MAPK) family signal transduction molecules . Positive_regulation MMP2 IL1B 19602123 2149833 *up-regulated* the levels of MMP-1 and [MMP-2] , but it did not alter the expression of extracellular MMP inducer . Positive_regulation MMP2 IL1B 19671357 2119498 ( 4 ng/ml ) significantly *increased* [MMP-2] activity of cultured fibroblasts in a time dependent manner . Positive_regulation MMP2 IL1B 19671357 2119499 *increased* [MMP-2] activity and transcription of human cardiac fibroblasts via iNOS-NO pathway . Positive_regulation MMP2 IL1B 19885578 2161155 TNF-alpha , , LPS and PMA , *stimulated* [MMP-2] in LC and inhibited MMP-2 in MM , but had no effect on MMP-9 . Positive_regulation MMP2 IL1B 20403707 2282290 *induced* [MMP] production was significantly augmented in the presence of sIL-6R . Positive_regulation MMP2 IL1B 20678474 2311834 [MMP-2] gene expression as well as enzymatic activities of MMP-2 and MMP-9 were *increased* by ( P < 0.05 vs. control ; 100ng/ml ; 3h for gene expression , 48 and 72h for enzymatic activities of MMP-2 and MMP-9 , respectively ) . Positive_regulation MMP2 IL1B 21344389 2480446 These findings establish CEBPB as a critical intermediate for dependent [MMP] gene *activation* and assign specific roles for the ERK and RSK kinases in this pathway . Positive_regulation MMP2 IL1B 22792188 2628387 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation MMP2 IL1B 9558121 500100 Recombinant TNF-alpha and added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP2 IL1B 9821179 548124 The inflammatory cytokine did not *induce* [MMP] or TIMP expression . Positive_regulation MMP2 IL1B 9890433 585421 A beta , but not or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells , as well as *increased* the expression of the well-known activator of MMP-2 , membrane-type ( MT ) [-MMP] . Positive_regulation MMP2 IL1B 9933437 589404 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by and TNF-alpha or down-regulated by IFN-gamma . Positive_regulation MMP2 MAP2K6 15147870 1248050 A specific inhibitor of 1/2 *inhibited* both [MMP 2] activation and extracellular signal related kinase phosphorylation induced by cholesterol depletion . Positive_regulation MMP2 MAP2K6 15509661 1367190 By contrast , expression of constitutively active was *sufficient* to stimulate [MMP-2] production in a monolayer of endothelial cells cultured on type I collagen . Positive_regulation MMP2 MAP2K6 17079470 1642907 Activation of p38 pathway by *caused* a selective up-regulation of [MMP-2] . Positive_regulation MMP2 MAP2K6 17357450 1712558 U0126,a inhibitor , could obviously *inhibit* the enhanced invasion and expression of MMP-9 and [MMP-2] of these cells induced by CsA ; Positive_regulation MMP2 MAP2K6 19833163 2196167 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP2 MAP2K6 20545600 2308461 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP2 MAP2K6 21453685 2422075 a5ß1 monoclonal antibody and MAPK kinase ( ) inhibitors ( PD98059 and U0126 ) *inhibited* the WISP-1 induced increase of the migration and [MMP-2] up-regulation of chondrosarcoma cells . Positive_regulation MMP2 MAP2K6 22310287 2718995 Most importantly , and surprisingly , inhibition *results* in a significant increase in [matrix metalloproteases (MMP)-2] and membrane-type 1-MMP expression . Positive_regulation MMP2 MMP28 10197640 604827 Aggregation of beta1 integrins with immobilized 21C8 or P4C10 antibodies stimulated *dependent* [pro-MMP-2] activation and accumulation of a M ( r ) 43,000 form of membrane type 1 MMP (MT1-MMP) , a cell surface activator of pro-MMP-2 , in cell extracts . Positive_regulation MMP2 MMP28 10197640 604849 Treatment of control cells with concanavalin A stimulated *dependent* [pro-MMP-2] activation and accumulation of M ( r ) 55,000 and 43,000 forms of MT1-MMP in cell extracts . Positive_regulation MMP2 MMP28 10333542 615115 *Activation* of [pro-MMP-2] by membrane ( MT-MMP ) is reported to be a rate limiting step for catalytic function . Positive_regulation MMP2 MMP28 10377072 623591 In this study , we tested the hypothesis that membrane type 1 MMP (MT1-MMP) , a novel transmembrane that *activates* [pro-MMP-2] ( gelatinase A ) , is expressed in human atherosclerotic plaques and that its expression is regulated by proinflammatory molecules . Positive_regulation MMP2 MMP28 10642509 660842 Both in the insect cells and in vitro , *activation* of [pro-MMP-2] by was enhanced at low concentrations of TIMP-2 and inhibited by its higher concentrations . Positive_regulation MMP2 MMP28 10642509 660907 In contrast , *activation* of [pro-MMP-2] by was dose-dependently inhibited by TIMP-2 . Positive_regulation MMP2 MMP28 11114732 759269 In addition , activation of and tyrosine phosphorylation of FAK by Con A , but not the proteolytic *activation* of [MMP-2] , required attachment of the cells to the extracellular matrix . Positive_regulation MMP2 MMP28 11340084 812350 The Rac1 dependent [MMP-2] activation occurred in a cell associated fashion and *required* activities . Positive_regulation MMP2 MMP28 11382769 835047 In contrast to the stimulatory effect of TIMP-2 on pro-MMP-2 activation by MT1-MMP , *activation* of [pro-MMP-2] by in the presence of claudin-5 and proDeltaMMP-2 processing by MT1-MMP were both inversely repressed by expression of exogenous TIMP-2 . Positive_regulation MMP2 MMP28 11382769 835079 Stimulation of mediated [pro-MMP-2] *activation* was also observed with other claudin family members , claudin-1 , claudin-2 , and claudin-3 . Positive_regulation MMP2 MMP28 11415441 829065 These results indicate that in HUVECs the activation of [pro-MMP-2] by thrombin *involves* increased activity and preferential cleavage of the MT-MMP processed 64 kDa MMP-2 form in the presence of cells . Positive_regulation MMP2 MMP28 11598905 870559 MMP-2 activation by PMN conditioned medium or purified elastase was blocked by the elastase inhibitor alpha(1)-antitrypsin but not by Batimastat , an MMP inhibitor , showing that elastase activation of [MMP-2] is not *mediated* by activities . Positive_regulation MMP2 MMP28 11606407 871639 The inhibitor , BB-94 , *blocked* [MMP-2] activity and invasion associated with Akt1- and v-akt expressing cells . Positive_regulation MMP2 MMP28 11688960 766273 This model should prove useful in further characterizing the regulation of *mediated* [MMP-2] activation and delineating the EMT in breast cancer progression . Positive_regulation MMP2 MMP28 11858950 914693 To study the *role* of in the activation of [MMP-2] , skin specimens of DF ( five cases ) and MFH ( three cases ) were immunohistochemically studied using in situ zymography and the antibodies against matrix metalloproteinase-2 (MMP-2) and membrane type 1-3-MMPs (MT1-3-MMPs) . Positive_regulation MMP2 MMP28 12608904 1063094 The activation of [MMP-2] was *inhibited* by inhibitors phenanthroline and EDTA , but not serine protease or cysteine protease inhibitors . Positive_regulation MMP2 MMP28 12747454 1088836 Recent studies have indicated that a novel transmembrane , mebrane-type 1 matrix metalloproteinase ( MT1-MMP ) , can *activate* [pro-MMP-2] in tumor metastasis . Positive_regulation MMP2 MMP28 12755684 1133920 TIMP-2 ( tissue inhibitor of metalloproteinase-2 ) regulates MMP-2 ( matrix metalloproteinase-2 ) activity in the extracellular environment after [pro-MMP-2] *activation* by MT1 ( membrane type 1 ) <-MMP> . Positive_regulation MMP2 MMP28 12783419 1096346 ICH increased brain [MMP-2] , -3 , -7 , and -9 mRNA levels relative to sham injected ( control ) animals in the vicinity of the hematoma , but MMP-12 ( macrophage metalloelastase ) was the most highly *induced* ( > 80-fold ) . Positive_regulation MMP2 MMP28 12861074 1114023 Conversely , inhibitors *suppressed* Ang2 stimulated activation of [MMP-2] and Ang2 induced cell invasion . Positive_regulation MMP2 MMP28 12878590 1142564 Distinct roles of catalytic and pexin-like domains in membrane-type *mediated* [pro-MMP-2] activation and collagenolysis . Positive_regulation MMP2 MMP28 14767645 1207825 ( 2 ) Immunohistochemical study : By using the alkaline phosphate-anti-alkaline phosphatase or avidin-biotin complex method , corneal or conjunctival tissue was examined for the presence of MMP-2 , MMP-9 , and membrane type 1 <(MT1)-MMP> , which *activates* [MMP-2] . Positive_regulation MMP2 MMP28 15247230 1289725 Treatment of oral squamous cell carcinoma cells with TGF-beta1 promoted *dependent* cell scattering and collagen invasion , increased expression of MMP-2 and MT1-MMP , and enhanced [MMP-2] activation . Positive_regulation MMP2 MMP28 15530852 1332754 Both recombinant human TIMP-1 and the synthetic inhibitors , GM6001 and [MMP-2-MMP-9] *Inhibitor* III , suppressed migration of human dermal microvascular endothelial cells ( HDMVEC ) in a dose dependent fashion . Positive_regulation MMP2 MMP28 15637056 1380972 The molecular mass of cleaved MMP-2 ( 63 kDa ) , detected in both cell lysates and conditioned medium , is between the intermediate and fully activated forms of [MMP-2] *induced* by membrane type <1-MMP> . Positive_regulation MMP2 MMP28 16896935 1607780 In fibroblasts of five normal subjects , grown at 5.5 or 22 mmol/l glucose and treated with homocysteine , we determined : ( 1 ) [MMP2] , MMP9 and tissue *inhibitor* of metalloproteinases ( TIMP)-1 (an inhibitor ) production by western blot analysis ; Positive_regulation MMP2 MMP28 18329693 1898087 Membrane-type-1 ( MMP14 ) *activates* [MMP2] using pro-MMP2 specific inhibitor , tissue inhibitor of matrix proteinase 2 ( TIMP2 ) , as a receptor . Positive_regulation MMP2 MMP28 18979185 2021791 Expression and activity of MMP-2 and MMP-9 in the non-infarct area was higher in KO-MI group 3 days post-MI . inhibition *reduced* [MMP-2] activity in KO-MI with no effect on the expression of TIMP-2 and TIMP-4 14 days post-MI . Positive_regulation MMP2 MMP28 19224446 2039813 *Activation* of [matrix metalloproteinase (MMP)-2] by membrane type <1-MMP> and abnormal immunolocalization of the basement membrane components laminin and type IV collagen in canine spontaneous hemangiosarcomas . Positive_regulation MMP2 MMP28 19375502 2100653 Over-expression of activatable , but not catalytically inactive EA mutant *increased* the expression and activity of [MMP-2] , and all forms of MMP-28 tested increased expression of MMP19 and TIMP3 mRNA . Positive_regulation MMP2 MMP28 21414971 2489380 Here , we investigated the roles of [matrix metalloproteinase (MMP)-2] , which is *activated* from proMMP-2 by membrane-type ( MT ) <-MMP> in the sclerotic and endothelial cell injury process of a type II diabetic model , Otsuka Long-Evans Tokushima Fatty ( OLETF ) rats . Positive_regulation MMP2 MMP28 21573477 243119 [MMP-2] was *detected* in all high-grade gliomas , while an additional or two were detected in only two cell lines , U87MG and KINGS-1 . Positive_regulation MMP2 MMP28 7630026 316802 These results indicated that [MMP-2] , which is *activated* by expressed on the surface of tumor cells , play a role in tumor metastasis by degrading surrounding basement membranes . Positive_regulation MMP2 MMP28 7822314 293026 The expression of *induced* specific activation of 72-kDa [pro-gelatinase A] ( Sato , H. , Takino , T. , Okada , Y. , Cao , J. , Shinagawa , A. , Yamamoto , E. , and Seiki , M. ( 1994 ) Nature 370 , 61-65 ) . Positive_regulation MMP2 MMP28 8560972 340193 Membrane-type matrix metalloprotease ( ) is an *activator* of [gelatinase A] ( MMP-2 ) , which has previously been found in carcinoma cells . Positive_regulation MMP2 MMP28 8646366 363352 This can *activate* [gelatinase A] , involved in the degradation of basement membranes . Positive_regulation MMP2 MMP28 9602249 506703 [MMP-2] is *activated* by a membrane bound ( MT1-MMP ) . Positive_regulation MMP2 MMP28 9769392 538739 Membrane type matrix metalloproteinase ( ) has a potential transmembrane domain at the C terminus and *activates* [pro-MMP-2] , which is mainly produced from interstitial fibroblasts . Positive_regulation MMP2 MMP28 9856832 555212 Membrane-type matrix metalloproteinases ( ) *activate* the zymogen form of [MMP-2/Gelatinase] A on cell surfaces and are expressed in invasive tumors . Positive_regulation MMP2 MMP7 10197640 604842 Aggregation of beta1 integrins with immobilized 21C8 or P4C10 antibodies stimulated *dependent* [pro-MMP-2] activation and accumulation of a M ( r ) 43,000 form of membrane type 1 MMP (MT1-MMP) , a cell surface activator of pro-MMP-2 , in cell extracts . Positive_regulation MMP2 MMP7 10197640 604864 Treatment of control cells with concanavalin A stimulated *dependent* [pro-MMP-2] activation and accumulation of M ( r ) 55,000 and 43,000 forms of MT1-MMP in cell extracts . Positive_regulation MMP2 MMP7 10333542 615130 *Activation* of [pro-MMP-2] by membrane type-MMP ( ) is reported to be a rate limiting step for catalytic function . Positive_regulation MMP2 MMP7 10377072 623606 In this study , we tested the hypothesis that membrane type 1 MMP (MT1-MMP) , a novel transmembrane that *activates* [pro-MMP-2] ( gelatinase A ) , is expressed in human atherosclerotic plaques and that its expression is regulated by proinflammatory molecules . Positive_regulation MMP2 MMP7 10642509 660857 Both in the insect cells and in vitro , *activation* of [pro-MMP-2] by was enhanced at low concentrations of TIMP-2 and inhibited by its higher concentrations . Positive_regulation MMP2 MMP7 10642509 660922 In contrast , *activation* of [pro-MMP-2] by was dose-dependently inhibited by TIMP-2 . Positive_regulation MMP2 MMP7 11114732 759284 In addition , activation of and tyrosine phosphorylation of FAK by Con A , but not the proteolytic *activation* of [MMP-2] , required attachment of the cells to the extracellular matrix . Positive_regulation MMP2 MMP7 11340084 812365 The Rac1 dependent [MMP-2] activation occurred in a cell associated fashion and *required* activities . Positive_regulation MMP2 MMP7 11382769 835062 In contrast to the stimulatory effect of TIMP-2 on pro-MMP-2 activation by MT1-MMP , *activation* of [pro-MMP-2] by in the presence of claudin-5 and proDeltaMMP-2 processing by MT1-MMP were both inversely repressed by expression of exogenous TIMP-2 . Positive_regulation MMP2 MMP7 11382769 835094 Stimulation of *mediated* [pro-MMP-2] activation was also observed with other claudin family members , claudin-1 , claudin-2 , and claudin-3 . Positive_regulation MMP2 MMP7 11415441 829080 These results indicate that in HUVECs the activation of [pro-MMP-2] by thrombin *involves* increased activity and preferential cleavage of the MT-MMP processed 64 kDa MMP-2 form in the presence of cells . Positive_regulation MMP2 MMP7 11598905 870574 MMP-2 activation by PMN conditioned medium or purified elastase was blocked by the elastase inhibitor alpha(1)-antitrypsin but not by Batimastat , an MMP inhibitor , showing that elastase activation of [MMP-2] is not *mediated* by activities . Positive_regulation MMP2 MMP7 11606407 871654 The inhibitor , BB-94 , *blocked* [MMP-2] activity and invasion associated with Akt1- and v-akt expressing cells . Positive_regulation MMP2 MMP7 11688960 766288 This model should prove useful in further characterizing the regulation of *mediated* [MMP-2] activation and delineating the EMT in breast cancer progression . Positive_regulation MMP2 MMP7 11858950 914708 To study the *role* of in the activation of [MMP-2] , skin specimens of DF ( five cases ) and MFH ( three cases ) were immunohistochemically studied using in situ zymography and the antibodies against matrix metalloproteinase-2 (MMP-2) and membrane type 1-3-MMPs (MT1-3-MMPs) . Positive_regulation MMP2 MMP7 12608904 1063109 The activation of [MMP-2] was *inhibited* by inhibitors phenanthroline and EDTA , but not serine protease or cysteine protease inhibitors . Positive_regulation MMP2 MMP7 12747454 1088851 Recent studies have indicated that a novel transmembrane , mebrane-type 1 matrix metalloproteinase ( MT1-MMP ) , can *activate* [pro-MMP-2] in tumor metastasis . Positive_regulation MMP2 MMP7 12755684 1133935 TIMP-2 ( tissue inhibitor of metalloproteinase-2 ) regulates MMP-2 ( matrix metalloproteinase-2 ) activity in the extracellular environment after [pro-MMP-2] *activation* by MT1 ( membrane type 1 ) <-MMP> . Positive_regulation MMP2 MMP7 12783419 1096361 ICH increased brain [MMP-2] , -3 , -7 , and -9 mRNA levels relative to sham injected ( control ) animals in the vicinity of the hematoma , but MMP-12 ( macrophage metalloelastase ) was the most highly *induced* ( > 80-fold ) . Positive_regulation MMP2 MMP7 12820423 1104005 [MMP-2] can be *activated* by , which is expressed in the tumour cells . Positive_regulation MMP2 MMP7 12861074 1114039 Conversely , inhibitors *suppressed* Ang2 stimulated activation of [MMP-2] and Ang2 induced cell invasion . Positive_regulation MMP2 MMP7 12878590 1142579 Distinct roles of catalytic and pexin-like domains in membrane-type *mediated* [pro-MMP-2] activation and collagenolysis . Positive_regulation MMP2 MMP7 14767645 1207840 ( 2 ) Immunohistochemical study : By using the alkaline phosphate-anti-alkaline phosphatase or avidin-biotin complex method , corneal or conjunctival tissue was examined for the presence of MMP-2 , MMP-9 , and membrane type 1 <(MT1)-MMP> , which *activates* [MMP-2] . Positive_regulation MMP2 MMP7 15247230 1289740 Treatment of oral squamous cell carcinoma cells with TGF-beta1 promoted *dependent* cell scattering and collagen invasion , increased expression of MMP-2 and MT1-MMP , and enhanced [MMP-2] activation . Positive_regulation MMP2 MMP7 15530852 1332769 Both recombinant human TIMP-1 and the synthetic inhibitors , GM6001 and [MMP-2-MMP-9] *Inhibitor* III , suppressed migration of human dermal microvascular endothelial cells ( HDMVEC ) in a dose dependent fashion . Positive_regulation MMP2 MMP7 15637056 1380987 The molecular mass of cleaved MMP-2 ( 63 kDa ) , detected in both cell lysates and conditioned medium , is between the intermediate and fully activated forms of [MMP-2] *induced* by membrane type <1-MMP> . Positive_regulation MMP2 MMP7 15782307 1403685 The induction of these MMPs likely contributes to tissue destruction associated with the fibrogenic process , while augmenting the *activation* of [MMP-2] and MMP-9 by MMP-3 and in XLAS . Positive_regulation MMP2 MMP7 16152587 1517319 Using Western blotting , we show that VEGF , at 20-80 ng/ml , induced secretion of and pro-MMP-9 and *activation* of [pro-MMP-2] in DOV13 conditioned medium in a concentration dependent manner . Positive_regulation MMP2 MMP7 16574944 1598093 No increases in RNA levels of [MMP-2] , MMP-9 , or MMP-8 were found , but levels of , MMP-12 , and MMP-13 RNA did *increase* at 14 d . Positive_regulation MMP2 MMP7 16896935 1607795 In fibroblasts of five normal subjects , grown at 5.5 or 22 mmol/l glucose and treated with homocysteine , we determined : ( 1 ) [MMP2] , MMP9 and tissue *inhibitor* of metalloproteinases ( TIMP)-1 (an inhibitor ) production by western blot analysis ; Positive_regulation MMP2 MMP7 18329693 1898102 Membrane-type-1 ( MMP14 ) *activates* [MMP2] using pro-MMP2 specific inhibitor , tissue inhibitor of matrix proteinase 2 ( TIMP2 ) , as a receptor . Positive_regulation MMP2 MMP7 18979185 2021806 Expression and activity of MMP-2 and MMP-9 in the non-infarct area was higher in KO-MI group 3 days post-MI . inhibition *reduced* [MMP-2] activity in KO-MI with no effect on the expression of TIMP-2 and TIMP-4 14 days post-MI . Positive_regulation MMP2 MMP7 19224446 2039828 *Activation* of [matrix metalloproteinase (MMP)-2] by membrane type <1-MMP> and abnormal immunolocalization of the basement membrane components laminin and type IV collagen in canine spontaneous hemangiosarcomas . Positive_regulation MMP2 MMP7 21414971 2489395 Here , we investigated the roles of [matrix metalloproteinase (MMP)-2] , which is *activated* from proMMP-2 by membrane-type ( MT ) <-MMP> in the sclerotic and endothelial cell injury process of a type II diabetic model , Otsuka Long-Evans Tokushima Fatty ( OLETF ) rats . Positive_regulation MMP2 MMP7 21573477 243134 [MMP-2] was *detected* in all high-grade gliomas , while an additional or two were detected in only two cell lines , U87MG and KINGS-1 . Positive_regulation MMP2 MMP7 2174435 145674 collagenase mRNA increased approximately 16-fold , [MMP-2] increased 2-fold , and , a recently described MMP gene , was *induced* . Positive_regulation MMP2 MMP7 7630026 316817 These results indicated that [MMP-2] , which is *activated* by expressed on the surface of tumor cells , play a role in tumor metastasis by degrading surrounding basement membranes . Positive_regulation MMP2 MMP7 7822314 293041 The expression of *induced* specific activation of 72-kDa [pro-gelatinase A] ( Sato , H. , Takino , T. , Okada , Y. , Cao , J. , Shinagawa , A. , Yamamoto , E. , and Seiki , M. ( 1994 ) Nature 370 , 61-65 ) . Positive_regulation MMP2 MMP7 8560972 340208 Membrane-type matrix metalloprotease ( ) is an *activator* of [gelatinase A] ( MMP-2 ) , which has previously been found in carcinoma cells . Positive_regulation MMP2 MMP7 8646366 363367 This can *activate* [gelatinase A] , involved in the degradation of basement membranes . Positive_regulation MMP2 MMP7 9602249 506718 [MMP-2] is *activated* by a membrane bound ( MT1-MMP ) . Positive_regulation MMP2 MMP7 9769392 538754 Membrane type matrix metalloproteinase ( ) has a potential transmembrane domain at the C terminus and *activates* [pro-MMP-2] , which is mainly produced from interstitial fibroblasts . Positive_regulation MMP2 MMP7 9856832 555227 Membrane-type matrix metalloproteinases ( ) *activate* the zymogen form of [MMP-2/Gelatinase A] on cell surfaces and are expressed in invasive tumors . Positive_regulation MMP2 NNMT 21045016 2376312 Furthermore , SP-1 binding region of MMP-2 promoter was found to be essential in *induced* [MMP-2] expression . Positive_regulation MMP2 OXTR 16958049 1666217 *increased* pro- and active [MMP-2] and MMP-9 , compared with healthy and burned controls and therefore accelerated remodeling . Positive_regulation MMP2 PLAT 17561000 1753397 This change correlated with increased ( tPA ) activity , and *increased* matrix metalloproteinase-9 (MMP-9) , but not [MMP-2] activity . Positive_regulation MMP2 PLAU 10615432 575803 Epithelioid SMC , but not swirling SMC , secreted [MMP-2] in *response* to and tPA . Positive_regulation MMP2 PLAU 11069499 747817 The activity of [MMP-2] is *potentiated* by binding of to the uPA receptor (uPAR) . Positive_regulation MMP2 PLAU 16554301 1562038 2 ) activation of plasminogen by and subsequent *activation* of transforming growth factor-beta1 ( TGF-beta1 ) and [matrix metalloproteinase (MMP)-2] and -9 by plasmin are critical pathways through which uPA expressing macrophages accumulate in the heart and cause fibrosis ; Positive_regulation MMP2 PLAU 19735728 2147178 We report that , as well as its catalytically inactive N-amino fragment ATF , *triggers* the sequential activation of [MMP-2] , NSMase-2 and ERK1/2 in ECV304 cells that are required for uPA induced ECV304 proliferation , as assessed by the inhibitory effect of Marimastat ( a MMP inhibitor ) , MMP-2-specific siRNA , MMP-2 defect , and NSMase-specific siRNA . Positive_regulation MMP2 PODXL 17616675 1769338 These findings suggest that leads to increased in vitro migration and invasion , *increased* [MMP] expression , and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MMP2 SPHK1 22684547 2705932 Moreover , was *required* for the production of [MMP-2/9] and uPA in tumor cells , which was suppressed by ERK1/2 inhibitor U0126 , but enhanced by the p38 MAPK inhibitor SB203580 . Positive_regulation MMP2 TGM2 19324884 2080304 *regulates* [matrix metalloproteinase-2] in ovarian cancer by modulating cAMP-response element binding protein activity . Positive_regulation MMP2 TGM2 23201552 2730747 Gene silencing of suppressed the migration and invasion of HT-1080 cells and *suppressed* the activities of [MMP-2] and MMP-9 . Positive_regulation MMP2 TGM2 24130925 2714728 Gene silencing of *suppressed* the [MMP] expression by ATRA . Positive_regulation MMP2 TLR7 18802113 1964786 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP2 TNF 10482270 643784 We also examined the possibility that such MMPs could be produced by brain derived cells , and that [MMP] production by these cells might be *increased* by , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD . Positive_regulation MMP2 TNF 10864917 705846 IL-1beta and each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP2 TNF 11014232 736346 Using a primary culture model in which rat MEC grow three-dimensionally within a reconstituted basement membrane , we found that *stimulated* secretion of MMP-9 but not [MMP-2] . Positive_regulation MMP2 TNF 11112697 768054 To investigate this observation at the cellular and molecular levels , we examined *mediated* activation of [pro-MMP-2] , induction of MT1-MMP , and the intracellular signaling pathways that regulate the proteinase in isolated human dermal fibroblasts . Positive_regulation MMP2 TNF 11112697 768055 We found that substantially *promoted* activation of [pro-MMP-2] in dermal fibroblasts embedded in type-I collagen . Positive_regulation MMP2 TNF 11147175 760930 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that may *induce* [MMP] production followed by matrix degradation within foreign body granulomas . Positive_regulation MMP2 TNF 11480246 843587 and IL-1 beta *induced* increases in the concentrations of MMP-1 , MMP-3 , and MMP-9 , but not in [MMP-2] or tissue inhibitor of matrix metalloproteinase ( TIMP ) -1 or -2 . Positive_regulation MMP2 TNF 11487146 845171 *stimulated* [MMP-2] activity in conditioned medium and stimulated MMP-9 activity with addition of plasminogen into conditioned medium . Positive_regulation MMP2 TNF 11773040 899407 Isolated RMVECs did not significantly increase [MMP] production directly in response to a hypoxic stimulus , but *required* the presence of exogenous . Positive_regulation MMP2 TNF 11916194 925460 IL-1beta and both induced a dose- and time dependent increase in IL-8 , MCP-1 and MMP-1 secretion , and weakly *stimulated* [MMP-2] secretion . Positive_regulation MMP2 TNF 12113550 963871 Because elevation of COX-2 mRNA levels enhances the production of prostaglandins , we therefore investigated whether endogenous prostaglandins are involved in the [MMP] mRNA expression that is *enhanced* by . Positive_regulation MMP2 TNF 12456593 1021285 IL-18 and IL-12 separately and synergistically *enhanced* [MMP-2] , while led to the elevation of MMP-9 . Positive_regulation MMP2 TNF 12480812 1024245 In cultured neonatal rat cardiac fibroblasts , reduced cellular [ 3H ] -proline incorporation , *increased* [matrix metalloproteinase-2 (MMP-2)] activity and protein , and increased TIMP-1 protein levels . Positive_regulation MMP2 TNF 12606436 1064583 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP2 TNF 12735637 1087473 Moreover , TGF-beta1 , , or epidermal growth factor *augmented* the secretion of [MMP-2] from fibroblasts . Positive_regulation MMP2 TNF 12909329 1121955 *mediates* the stretch induced [MMP] genes expression , at least in part , through the JNK pathway . Positive_regulation MMP2 TNF 14644777 1210224 Angiotensin II-induced [MMP-2] release from endothelial cells is *mediated* by . Positive_regulation MMP2 TNF 14644777 1210234 inhibition *prevented* the secretion of [MMP-2] induced by ANG II . Positive_regulation MMP2 TNF 14644777 1210239 These results indicate that ANG II , via AT(1)R , modulates the secretion of TNF-alpha and [MMP-2] from endothelial cells and that *mediates* the effects of ANG II on MMP-2 release . Positive_regulation MMP2 TNF 14673992 1178642 The in vivo data clearly indicated that OSM + overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP2 TNF 14967948 1182639 Both and TNF-beta strongly *stimulated* the production of [MMP-2] and MMP-9 , whereas IGFs had no effect . Positive_regulation MMP2 TNF 15044327 1272765 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to dependent [MMP] *induction* in the macrophages . Positive_regulation MMP2 TNF 15183075 1255923 One hour of pre-incubation with PDE4 inhibitors ( 10 microM ) induced an inhibition of *stimulated* [pro-MMP-2] release . Positive_regulation MMP2 TNF 15183075 1255925 These results suggest that PDE4 inhibitors are effective in inhibiting the [pro-MMP-2] and pro-MMP-1 secretion *induced* by and might underline a potential therapeutic benefit of selective PDE4 inhibitors in lung diseases associated with abnormal tissue remodelling . Positive_regulation MMP2 TNF 15184206 1280581 *causes* increased [MMP] production , but some increased MMP activity is present even in TNFRKO mice . Positive_regulation MMP2 TNF 15201935 1260866 IL-1 and are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP2 TNF 15380733 1298520 In this study , we investigated the inhibitory effect of CDS on *induced* human aortic smooth muscle cells ( HASMC ) migration and [MMP-2] and -9 activity . Positive_regulation MMP2 TNF 16549372 1582256 and OSM induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP2 TNF 16580738 1562457 NPCs ' gelatinase activities of [MMP-2] and MMP-9 , as determined by zymography , were *increased* by , and to a lesser extent by IFN-gamma . Positive_regulation MMP2 TNF 16580738 1562464 IFN-beta suppressed the *induced* levels of secreted MMP-9 and [MMP-2] , while enhancing the expression of TIMP-1 and TIMP-2 mRNA . Positive_regulation MMP2 TNF 16603966 1545151 Stimulation with induced secretion of MMP-9 and *increased* the secretion of [MMP-2] . Positive_regulation MMP2 TNF 16713603 1575813 Salvianolic acid B from Salvia miltiorrhiza inhibits *induced* [MMP-2] upregulation in human aortic smooth muscle cells via suppression of NAD(P)H oxidase derived reactive oxygen species . Positive_regulation MMP2 TNF 16713603 1575814 *enhances* NAD (P) H oxidase dependent reactive oxygen species ( ROS ) formation and ROS induce [MMP-2] . Positive_regulation MMP2 TNF 16713603 1575819 Our data point out that the importance of NADPH oxidase dependent ROS generation in the control of SalB inhibition of *induced* [MMP-2] expression and activity . Positive_regulation MMP2 TNF 16816895 1646004 After infection , mRNA levels *increased* rapidly to a peak on day one , and then trypsin I and matrix metalloproteinase (MMP)-9 , but not [MMP-2] , were significantly up-regulated with a peak on day 2 in vivo . Positive_regulation MMP2 TNF 16857167 1592379 However , blockade ( neutralizing antibodies against human TNFalpha , 25 microg/ml ) significantly *reduced* the activity of [MMP-2] and markers of apoptosis induced by TNFalpha . Positive_regulation MMP2 TNF 16934628 1608837 , IL-1beta , and IL-6 *increased* the mRNA and/or protein expression of MMP-1 , [MMP-2] , and MMP-3 . Positive_regulation MMP2 TNF 17062332 1637231 To investigate the regulatory effects of fenofibrate on *induced* CD40 expression and [matrix metalloproteinase (MMP)] activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation MMP2 TNF 17062332 1637244 Fenofibrate reduces *induced* increment of CD40 expression and [MMP-2] and MMP-9 activities in HUVECs . Positive_regulation MMP2 TNF 17469134 1737532 OSM and *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP2 TNF 17507431 1791865 Moreover , [MMP] activity in PCPEC supernatants was significantly *increased* by , presumably due to a diminished expression of TIMP-3 that was similarly observed . Positive_regulation MMP2 TNF 17876544 1796352 A similar augmentation was also observed in *induced* cytokine and [MMP] secretion . Positive_regulation MMP2 TNF 17964422 1820282 Besides , pretreatment with carvedilol or probucol but not propranolol , a beta-blocker , or prazocin , an alpha-blocker , inhibited *stimulated* expressions and activities of [MMP-2] and MMP-9 in human aortic smooth muscle cells . Positive_regulation MMP2 TNF 18276934 1911668 Similarly , quantitative RT-PCR found that and IL1B *enhanced* MMP9 , but not [MMP2] , mRNA levels . Positive_regulation MMP2 TNF 18277865 1872183 *induces* [MMP2] gelatinase activity and MT1-MMP expression in an in vitro model of nucleus pulposus tissue degeneration . Positive_regulation MMP2 TNF 18277865 1872207 treatment *induced* [MMP-2] gelatinase activity , which occurred in the absence of any change in MMP-2 gene or protein expression , but did correlate with increased MT1-MMP mRNA and protein levels . Positive_regulation MMP2 TNF 18277865 1872213 As ERK also appeared to regulate MT1-MMP production , this suggests that *induction* of [MMP-2] gelatinase activity may be regulated by MT1-MMP . Positive_regulation MMP2 TNF 18723334 1984965 In contrast , fibroblasts in areas of parenchymal destruction of emphysema/UIP expressed [MMP-2] , MMP-9 , MMP-7 and MT1-MMP at variable but significantly higher levels when compared to emphysema subjects , in the *presence* of similar levels of TIMP-1 , TIMP-2 and . Positive_regulation MMP2 TNF 19026560 2001516 suppressed collagen type II and aggrecan , but *increased* [MMP] and cytokine expression in chondrocytes compared to the non stimulated controls . Positive_regulation MMP2 TNF 19435506 2106979 does not *induce* [MMP] expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation MMP2 TNF 19672675 2132843 Gelatin zymography results showed that pretreatment with EGE to human umbilical vein endothelial cells ( HUVEC ) decreased *induced* increase of [matrix metalloproteinase (MMP)-2/-9] activities in the range of 1-50 microg/ml. Real-time qRT-PCR results also revealed that TNF-alpha induced MMP-2/-9 mRNA expression levels were attenuated by pretreatment with EGE . Positive_regulation MMP2 TNF 20007453 2210578 did not *induce* [MMP2] expression . Positive_regulation MMP2 TNF 20007453 2210594 We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since *induced* superoxide production , [MMP] expression , and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma . Positive_regulation MMP2 TNF 20010305 2191295 Mycobacterium leprae and *induced* upregulation of [MMP-2] and MMP-9 and increased secretion of these enzymes in cultured ST88-14 cells . Positive_regulation MMP2 TNF 20368952 1841305 The [MMP-2] gelatinolytic activity of endothelial cells was *enhanced* by , which was attenuated by an addition of > /=25 microM resveratrol . Positive_regulation MMP2 TNF 20403361 2267433 While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha , however , [matrix metalloproteinase (MMP)] *activation* of may also be contributory . Positive_regulation MMP2 TNF 20943041 2332958 Both and TGF-beta were found to divergently *enhance* MMP-9 and [MMP-2] secretion respectively , with stimulation indexes of two and five respectively . Positive_regulation MMP2 TNF 20956574 2369350 Supernatants from B. abortus infected monocytes induced [MMP-2] secretion in uninfected osteoblasts , and this effect was *mediated* by . Positive_regulation MMP2 TNF 21518085 2423046 It has been reported that *induces* the production of [matrix metalloproteinase-2 (MMP-2)] and transforming growth factor-ß1 ( TGF-ß1 ) in fibroblasts . Positive_regulation MMP2 TNF 21518085 2423047 In this study , we demonstrated that the active MMP-2 secreted by lung fibroblasts reached the peak level at 12 hours after TNF-a treatment , whereas , by adding anti-TGF-ß1 antibody in the culture medium , the [MMP-2] production in *response* to was maintained at high levels after 24 hours of treatment . Positive_regulation MMP2 TNF 21518085 2423052 Taken together , our results demonstrate that induced an *increase* of [MMP-2] and TGF-ß1 in lung fibroblasts , and the TGF-ß1 attenuated the up-regulation of MMP-2 . Positive_regulation MMP2 TNF 21792602 2554467 IL-1ß or *increased* expression of MMP-9 and [MMP-2] in rheumatoid synoviocytes ; Positive_regulation MMP2 TNF 21792602 2554473 genistein suppressed production of MMP-9 more than [MMP-2] *induced* by IL-1ß or ; Positive_regulation MMP2 TNF 21792602 2554477 Neither PD098059 nor SP600 125 could inhibit the [MMP-2] expression *induced* by or IL-1ß . Positive_regulation MMP2 TNF 22060290 2504134 Monascus purpureus fermented rice inhibits *induced* upregulation of [matrix metalloproteinase 2] and 9 in human aortic smooth muscle cells . Positive_regulation MMP2 TNF 22060290 2504136 RT-PCR and immunoblot analyses show that Cholestin extract significantly attenuates *induced* mRNA and protein expressions of [MMP-2] and MMP-9 . Positive_regulation MMP2 TNF 22060290 2504138 Cholestin reduces *stimulated* [MMP-2] and MMP-9 expression as well as downregulating NF-?B activation and intracellular ROS formation in HASMCs , supporting the notion that the natural compound Cholestin may have potential application in clinical atherosclerosis disease . Positive_regulation MMP2 TNF 22155307 2531181 HO-1 induction significantly reduced the expression of matrix metalloproteinase (MMP)-1 , [MMP-2] and MMP-3 , and the production of pro-inflammatory cytokines such as and IL-6 whereas IL-10 levels *increased* . Positive_regulation MMP2 TNF 22336124 2520794 To investigate the effect of focal adhesional kinase ( FAK ) on *induced* [MMP-2] and -9 activities in cornea epithelium . Positive_regulation MMP2 TNF 22336124 2520796 After down regulating the protein FAK , *had* no effect on the activity of [MMP-2] ( The data of MMP-2 were 55.13 ± 0.66 , 55.67 ± 0.43 , 55.49 ± 0.20 and 55.91 ± 0.37 in groups A , B , C and D , F = 2.73 , P = 0.079 ) . Positive_regulation MMP2 TNF 22710949 2687009 *stimulates* [MMP-2] and MMP-9 activities in human corneal epithelial cells via the activation of FAK/ERK signaling . Positive_regulation MMP2 TNF 22710949 2687014 Furthermore , *stimulated* [MMP-2] and MMP-9 activities in a dose dependent manner , but either knockdown of focal adhesion kinase ( FAK ) by short interference RNA or inhibition of extracellular regulated protein kinase ( ERK ) by chemical inhibitor could block TNF-a stimulated MMP-2 and MMP-9 activities in vitro . Positive_regulation MMP2 TNF 22710949 2687017 Taken together , our results provide in vivo evidence that the TNF-a level is positively correlated with MMP-2 and MMP-9 levels in a HSK model and in vitro evidence that *stimulates* [MMP-2] and MMP-9 activities via the activation of FAK/ERK signaling in HCE cells . Positive_regulation MMP2 TNF 23417988 2843312 SUMO-2/3 was knocked down using small interfering RNA in SFs , and *induced* [MMP] production was determined by ELISA . Positive_regulation MMP2 TNF 23417988 2843345 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by TNF-a and selectively control *mediated* [MMP] expression via the NF-?B pathway . Positive_regulation MMP2 TNF 23603294 2795188 Furthermore , infliximab effectively attenuated the *induced* increases in [MMP] expression in cells that make up the BAB . Positive_regulation MMP2 TNF 23632129 2790699 In the present study , we evaluated the effect of largazole (LAR) , a marine derived class I HDAC inhibitor , on *induced* expression of intercellular adhesion molecule-1 ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) , and [matrix metalloproteinase-2 (MMP-2)] activity . Positive_regulation MMP2 TNF 23632129 2790716 However , LAR inhibited *induced* [MMP-2] activity in RA synovial fibroblasts by 35 % when compared to the TNF-a treated group . Positive_regulation MMP2 TNF 23676255 2801077 Consistent with the in vivo data , TLR3 deficiency suppressed [MMP-2] activity *induced* by or polyinosine-polycytidylic acid in macrophages from Apoe ( -/- ) Npc1 ( -/- ) mice . Positive_regulation MMP2 TNF 23843954 2816523 Carvedilol decrease IL-1ß and , *inhibits* [MMP-2] , MMP-9 , COX-2 , and RANKL expression , and up-regulates OPG in a rat model of periodontitis . Positive_regulation MMP2 TNF 24030463 2851507 Evidence is provided that SNC-121 attenuated *induced* [MMP-2] secretion from ONH astrocytes . Positive_regulation MMP2 TNF 24085323 2857994 In chondrosarcoma cells , had a stimulatory effect on MMP-9 and insignificant effect on MMP-2 and interleukin (IL)-1ß *stimulated* MMP-9 and [MMP-2] . Positive_regulation MMP2 TNF 24190483 2885897 *stimulated* rhabdomyosarcoma [MMP-2] expression , but had no effect on MMP-9 secretion . Positive_regulation MMP2 TNF 7543547 314349 Northern hybridization assays showed pretranslational control of PMA- , basic fibroblast growth factor- , and *induced* [MMP] expression . Positive_regulation MMP2 TNF 7802656 284524 The expression of [gelatinase A] in HIV infected cells was selectively *increased* by ( TNF alpha ) while the expression of gelatinase B was not affected . Positive_regulation MMP2 TNF 8045973 266924 Both interleukin-1 alpha and *stimulated* the secretion of MMP-1 , MMP-3 , and MMP-9 , but not [MMP-2] , from the cells in a concentration dependent manner . Positive_regulation MMP2 TNF 8556714 347391 ( 0.1-30 ng/ml ) significantly stimulated 92 kDa gelatinase secretion in a dose dependent manner , but did not significantly *stimulate* [72 kDa gelatinase] secretion . Positive_regulation MMP2 TNF 9014820 405381 Although MMP-2 is constitutively secreted by synovial fibroblasts as a pro-enzyme , stimulation of fibroblasts by *induced* secretion of [MMP-2] in an active form . Positive_regulation MMP2 TNF 9014820 405419 In support of this result , stimulation *induced* membrane-type matrix metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation MMP2 TNF 9014820 405427 Our results suggest that *induces* [MMP-2] activation in part by up-regulating MT-MMP expression , thus representing a new mechanism for cytokine mediated articular destruction in rheumatoid arthritis ( RA ) . Positive_regulation MMP2 TNF 9130458 426867 This study examined the *role* of IFN-gamma and ( + ) in the regulation of the matrix metalloproteinases , [MMP-2] ( 72 kD gelatinase A ) and MMP-9 ( 92 kD gelatinase B ) . Positive_regulation MMP2 TNF 9558121 500099 Recombinant and IL-1beta added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP2 TNF 9631748 512571 *increased* the total [MMP] activity released . Positive_regulation MMP2 TNF 9927150 588420 In general , *stimulated* both [MMP] and TIMP expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation MMP2 TNF 9933437 589403 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by IL-1beta and or down-regulated by IFN-gamma . Positive_regulation MMP2 TNFSF10 20233617 2281596 In vitro [MMP2] *induced* the cleavage of recombinant and inactivated its ability of inducing apoptosis . Positive_regulation MMP20 CAPN8 21911754 2497076 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP20 CAPN8 21964156 2525854 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP20 CAPN8 22316244 2553360 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP20 CTGF 18632843 1979321 In conclusion , upregulation of inhibits BMP-7 signal transduction in the diabetic kidney and *contributes* to altered gene transcription , reduced [MMP] activity , glomerular basement membrane thickening , and albuminuria , all of which are hallmarks of diabetic nephropathy . Positive_regulation MMP20 EPHB2 14709335 1196658 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP20 EPHB2 20843518 2353070 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and *dependent* [MMP] expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation MMP20 EPHB2 24012928 2862357 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an [MMP] *inhibitor* , or PD98059 ( 50 µM ) , an inhibitor , also suppressed it . Positive_regulation MMP20 IGFBP1 15590975 1346159 Cell numbers were increased only by 100 nM IGFBP-1 isoforms ( P < 0.05 ) , whereas [MMP] levels released from term cells were optimally *increased* by 1-10 nM . Positive_regulation MMP20 IL1B 10727770 678129 and TPA alone *induced* [MMP] activity in HIG-82 cells . Positive_regulation MMP20 IL1B 10864917 705849 and TNF-alpha each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP20 IL1B 10895370 711612 In support of this result , stimulation *induced* the expression of membrane type matrix-metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation MMP20 IL1B 11327259 807596 A decrease in IL-1alpha , , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP20 IL1B 11467889 840803 In all cases , PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on *induction* of [MMP] expression . Positive_regulation MMP20 IL1B 11997239 939302 produced a dose dependent *increase* in [MMP] activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min . Positive_regulation MMP20 IL1B 14872494 1208456 Preincubation with anti-CD44 antibody , which suppressed IL-1beta stimulated MMPs , reversed the inhibitory effect of HA on [MMP] production that was *induced* by in normal and OA cartilage . Positive_regulation MMP20 IL1B 16449361 1573881 HA at > or =2 mg/ml significantly inhibited [MMP] production *induced* by in a dose dependent manner . Positive_regulation MMP20 IL1B 16449361 1573903 Inhibition studies revealed the requirement of NF-kappaB , p38 and c-jun NH2-terminal kinase ( JNK ) for *induced* [MMP] production . Positive_regulation MMP20 IL1B 17328062 1711904 SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on *stimulated* [MMP] production and collagen degradation . Positive_regulation MMP20 IL1B 17925024 1835387 These findings demonstrate , for the first time , that glucosamine inhibits *stimulated* [MMP] production in human chondrocytes by affecting MAPK phosphorylation . Positive_regulation MMP20 IL1B 18403593 1899536 DHA significantly decreased VSMC migration/proliferation *induced* by as well as [fibrinolytic/MMP] activity . Positive_regulation MMP20 IL1B 18535174 1928803 *stimulated* [MMP] mRNA synthesis in wild-type , but not in IL-1RI-null cardiac fibroblasts . Positive_regulation MMP20 IL1B 19056796 2017720 Cordycepin is a potent inhibitor of *induced* chemokine production and [MMP] expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs . Positive_regulation MMP20 IL1B 19542681 2099203 *induced* [MMP] production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ) , p38 kinase , and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase (MAPK) family signal transduction molecules . Positive_regulation MMP20 IL1B 20403707 2282291 *induced* [MMP] production was significantly augmented in the presence of sIL-6R . Positive_regulation MMP20 IL1B 21344389 2480447 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Positive_regulation MMP20 IL1B 22792188 2628388 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation MMP20 IL1B 9558121 500102 Recombinant TNF-alpha and added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP20 IL1B 9821179 548125 The inflammatory cytokine did not *induce* [MMP] or TIMP expression . Positive_regulation MMP20 IL1B 9890433 585422 A beta , but not or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells , as well as *increased* the expression of the well-known activator of MMP-2 , membrane-type ( MT ) [-MMP] . Positive_regulation MMP20 IL1B 9933437 589406 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by and TNF-alpha or down-regulated by IFN-gamma . Positive_regulation MMP20 MAP2K6 19833163 2196174 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP20 MAP2K6 20545600 2308468 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP20 MAP2K6 22310287 2719002 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP20 PODXL 17616675 1769339 These findings suggest that leads to increased in vitro migration and invasion , *increased* [MMP] expression , and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MMP20 TGM2 24130925 2714729 Gene silencing of *suppressed* the [MMP] expression by ATRA . Positive_regulation MMP20 TLR7 18802113 1964796 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP20 TNF 10482270 643785 We also examined the possibility that such MMPs could be produced by brain derived cells , and that [MMP] production by these cells might be *increased* by , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD . Positive_regulation MMP20 TNF 10864917 705848 IL-1beta and each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP20 TNF 11147175 760931 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that may *induce* [MMP] production followed by matrix degradation within foreign body granulomas . Positive_regulation MMP20 TNF 11773040 899408 Isolated RMVECs did not significantly increase [MMP] production directly in response to a hypoxic stimulus , but *required* the presence of exogenous . Positive_regulation MMP20 TNF 12113550 963872 Because elevation of COX-2 mRNA levels enhances the production of prostaglandins , we therefore investigated whether endogenous prostaglandins are involved in the [MMP] mRNA expression that is *enhanced* by . Positive_regulation MMP20 TNF 12606436 1064585 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP20 TNF 12909329 1121956 *mediates* the stretch induced [MMP] genes expression , at least in part , through the JNK pathway . Positive_regulation MMP20 TNF 14673992 1178644 The in vivo data clearly indicated that OSM + overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP20 TNF 15044327 1272766 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to dependent [MMP] *induction* in the macrophages . Positive_regulation MMP20 TNF 15184206 1280582 *causes* increased [MMP] production , but some increased MMP activity is present even in TNFRKO mice . Positive_regulation MMP20 TNF 15201935 1260868 IL-1 and are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP20 TNF 16549372 1582258 and OSM induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP20 TNF 17062332 1637232 To investigate the regulatory effects of fenofibrate on *induced* CD40 expression and [matrix metalloproteinase (MMP)] activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation MMP20 TNF 17469134 1737534 OSM and *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP20 TNF 17507431 1791866 Moreover , [MMP] activity in PCPEC supernatants was significantly *increased* by , presumably due to a diminished expression of TIMP-3 that was similarly observed . Positive_regulation MMP20 TNF 17876544 1796353 A similar augmentation was also observed in *induced* cytokine and [MMP] secretion . Positive_regulation MMP20 TNF 19026560 2001517 suppressed collagen type II and aggrecan , but *increased* [MMP] and cytokine expression in chondrocytes compared to the non stimulated controls . Positive_regulation MMP20 TNF 19435506 2106980 does not *induce* [MMP] expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation MMP20 TNF 20007453 2210595 We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since *induced* superoxide production , [MMP] expression , and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma . Positive_regulation MMP20 TNF 20403361 2267434 While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha , however , [matrix metalloproteinase (MMP)] *activation* of may also be contributory . Positive_regulation MMP20 TNF 23417988 2843313 SUMO-2/3 was knocked down using small interfering RNA in SFs , and *induced* [MMP] production was determined by ELISA . Positive_regulation MMP20 TNF 23417988 2843346 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by TNF-a and selectively control *mediated* [MMP] expression via the NF-?B pathway . Positive_regulation MMP20 TNF 23603294 2795189 Furthermore , infliximab effectively attenuated the *induced* increases in [MMP] expression in cells that make up the BAB . Positive_regulation MMP20 TNF 7543547 314350 Northern hybridization assays showed pretranslational control of PMA- , basic fibroblast growth factor- , and *induced* [MMP] expression . Positive_regulation MMP20 TNF 9014820 405420 In support of this result , stimulation *induced* membrane-type matrix metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation MMP20 TNF 9558121 500101 Recombinant and IL-1beta added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP20 TNF 9631748 512572 *increased* the total [MMP] activity released . Positive_regulation MMP20 TNF 9927150 588421 In general , *stimulated* both [MMP] and TIMP expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation MMP20 TNF 9933437 589405 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by IL-1beta and or down-regulated by IFN-gamma . Positive_regulation MMP21 CAPN8 21911754 2496894 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP21 CAPN8 21964156 2525672 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP21 CAPN8 22316244 2553178 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP21 CTGF 18632843 1979308 In conclusion , upregulation of inhibits BMP-7 signal transduction in the diabetic kidney and *contributes* to altered gene transcription , reduced [MMP] activity , glomerular basement membrane thickening , and albuminuria , all of which are hallmarks of diabetic nephropathy . Positive_regulation MMP21 EPHB2 14709335 1196630 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP21 EPHB2 20843518 2353056 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and *dependent* [MMP] expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation MMP21 EPHB2 24012928 2862322 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an [MMP] *inhibitor* , or PD98059 ( 50 µM ) , an inhibitor , also suppressed it . Positive_regulation MMP21 IGFBP1 15590975 1346146 Cell numbers were increased only by 100 nM IGFBP-1 isoforms ( P < 0.05 ) , whereas [MMP] levels released from term cells were optimally *increased* by 1-10 nM . Positive_regulation MMP21 IL1B 10727770 678094 and TPA alone *induced* [MMP] activity in HIG-82 cells . Positive_regulation MMP21 IL1B 10864917 705823 and TNF-alpha each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP21 IL1B 10895370 711577 In support of this result , stimulation *induced* the expression of membrane type matrix-metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation MMP21 IL1B 11327259 807557 A decrease in IL-1alpha , , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP21 IL1B 11467889 840790 In all cases , PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on *induction* of [MMP] expression . Positive_regulation MMP21 IL1B 11997239 939289 produced a dose dependent *increase* in [MMP] activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min . Positive_regulation MMP21 IL1B 14872494 1208443 Preincubation with anti-CD44 antibody , which suppressed IL-1beta stimulated MMPs , reversed the inhibitory effect of HA on [MMP] production that was *induced* by in normal and OA cartilage . Positive_regulation MMP21 IL1B 16449361 1573868 HA at > or =2 mg/ml significantly inhibited [MMP] production *induced* by in a dose dependent manner . Positive_regulation MMP21 IL1B 16449361 1573890 Inhibition studies revealed the requirement of NF-kappaB , p38 and c-jun NH2-terminal kinase ( JNK ) for *induced* [MMP] production . Positive_regulation MMP21 IL1B 17328062 1711891 SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on *stimulated* [MMP] production and collagen degradation . Positive_regulation MMP21 IL1B 17925024 1835205 These findings demonstrate , for the first time , that glucosamine inhibits *stimulated* [MMP] production in human chondrocytes by affecting MAPK phosphorylation . Positive_regulation MMP21 IL1B 18403593 1899523 DHA significantly decreased VSMC migration/proliferation *induced* by as well as [fibrinolytic/MMP] activity . Positive_regulation MMP21 IL1B 18535174 1928790 *stimulated* [MMP] mRNA synthesis in wild-type , but not in IL-1RI-null cardiac fibroblasts . Positive_regulation MMP21 IL1B 19056796 2017707 Cordycepin is a potent inhibitor of *induced* chemokine production and [MMP] expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs . Positive_regulation MMP21 IL1B 19542681 2099190 *induced* [MMP] production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ) , p38 kinase , and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase (MAPK) family signal transduction molecules . Positive_regulation MMP21 IL1B 20403707 2282278 *induced* [MMP] production was significantly augmented in the presence of sIL-6R . Positive_regulation MMP21 IL1B 21344389 2480434 These findings establish CEBPB as a critical intermediate for dependent [MMP] gene *activation* and assign specific roles for the ERK and RSK kinases in this pathway . Positive_regulation MMP21 IL1B 22792188 2628264 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation MMP21 IL1B 9558121 500076 Recombinant TNF-alpha and added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP21 IL1B 9821179 548089 The inflammatory cytokine did not *induce* [MMP] or TIMP expression . Positive_regulation MMP21 IL1B 9890433 585409 A beta , but not or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells , as well as *increased* the expression of the well-known activator of MMP-2 , membrane-type ( MT ) [-MMP] . Positive_regulation MMP21 IL1B 9933437 589380 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by and TNF-alpha or down-regulated by IFN-gamma . Positive_regulation MMP21 MAP2K6 19833163 2196083 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP21 MAP2K6 20545600 2308370 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP21 MAP2K6 22310287 2718911 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP21 PODXL 17616675 1769313 These findings suggest that leads to increased in vitro migration and invasion , *increased* [MMP] expression , and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MMP21 TGM2 24130925 2714716 Gene silencing of *suppressed* the [MMP] expression by ATRA . Positive_regulation MMP21 TLR7 18802113 1964666 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP21 TNF 10482270 643772 We also examined the possibility that such MMPs could be produced by brain derived cells , and that [MMP] production by these cells might be *increased* by , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD . Positive_regulation MMP21 TNF 10864917 705822 IL-1beta and each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP21 TNF 11147175 760918 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that may *induce* [MMP] production followed by matrix degradation within foreign body granulomas . Positive_regulation MMP21 TNF 11773040 899395 Isolated RMVECs did not significantly increase [MMP] production directly in response to a hypoxic stimulus , but *required* the presence of exogenous . Positive_regulation MMP21 TNF 12113550 963859 Because elevation of COX-2 mRNA levels enhances the production of prostaglandins , we therefore investigated whether endogenous prostaglandins are involved in the [MMP] mRNA expression that is *enhanced* by . Positive_regulation MMP21 TNF 12606436 1064557 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP21 TNF 12909329 1121943 *mediates* the stretch induced [MMP] genes expression , at least in part , through the JNK pathway . Positive_regulation MMP21 TNF 14673992 1178618 The in vivo data clearly indicated that OSM + overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP21 TNF 15044327 1272753 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to dependent [MMP] *induction* in the macrophages . Positive_regulation MMP21 TNF 15184206 1280569 *causes* increased [MMP] production , but some increased MMP activity is present even in TNFRKO mice . Positive_regulation MMP21 TNF 15201935 1260842 IL-1 and are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP21 TNF 16549372 1582232 and OSM induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP21 TNF 17062332 1637219 To investigate the regulatory effects of fenofibrate on *induced* CD40 expression and [matrix metalloproteinase (MMP)] activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation MMP21 TNF 17469134 1737508 OSM and *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP21 TNF 17507431 1791853 Moreover , [MMP] activity in PCPEC supernatants was significantly *increased* by , presumably due to a diminished expression of TIMP-3 that was similarly observed . Positive_regulation MMP21 TNF 17876544 1796340 A similar augmentation was also observed in *induced* cytokine and [MMP] secretion . Positive_regulation MMP21 TNF 19026560 2001504 suppressed collagen type II and aggrecan , but *increased* [MMP] and cytokine expression in chondrocytes compared to the non stimulated controls . Positive_regulation MMP21 TNF 19435506 2106967 does not *induce* [MMP] expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation MMP21 TNF 20007453 2210582 We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since *induced* superoxide production , [MMP] expression , and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma . Positive_regulation MMP21 TNF 20403361 2267421 While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha , however , [matrix metalloproteinase (MMP)] *activation* of may also be contributory . Positive_regulation MMP21 TNF 23417988 2843300 SUMO-2/3 was knocked down using small interfering RNA in SFs , and *induced* [MMP] production was determined by ELISA . Positive_regulation MMP21 TNF 23417988 2843333 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by TNF-a and selectively control *mediated* [MMP] expression via the NF-?B pathway . Positive_regulation MMP21 TNF 23603294 2795176 Furthermore , infliximab effectively attenuated the *induced* increases in [MMP] expression in cells that make up the BAB . Positive_regulation MMP21 TNF 7543547 314337 Northern hybridization assays showed pretranslational control of PMA- , basic fibroblast growth factor- , and *induced* [MMP] expression . Positive_regulation MMP21 TNF 9014820 405407 In support of this result , stimulation *induced* membrane-type matrix metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation MMP21 TNF 9558121 500075 Recombinant and IL-1beta added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP21 TNF 9631748 512559 *increased* the total [MMP] activity released . Positive_regulation MMP21 TNF 9927150 588408 In general , *stimulated* both [MMP] and TIMP expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation MMP21 TNF 9933437 589379 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by IL-1beta and or down-regulated by IFN-gamma . Positive_regulation MMP24 CAPN8 21911754 2497090 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP24 CAPN8 21964156 2525868 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP24 CAPN8 22316244 2553374 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP24 CTGF 18632843 1979322 In conclusion , upregulation of inhibits BMP-7 signal transduction in the diabetic kidney and *contributes* to altered gene transcription , reduced [MMP] activity , glomerular basement membrane thickening , and albuminuria , all of which are hallmarks of diabetic nephropathy . Positive_regulation MMP24 EPHB2 14709335 1196660 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP24 EPHB2 20843518 2353071 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and *dependent* [MMP] expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation MMP24 EPHB2 24012928 2862358 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an [MMP] *inhibitor* , or PD98059 ( 50 µM ) , an inhibitor , also suppressed it . Positive_regulation MMP24 IGFBP1 15590975 1346160 Cell numbers were increased only by 100 nM IGFBP-1 isoforms ( P < 0.05 ) , whereas [MMP] levels released from term cells were optimally *increased* by 1-10 nM . Positive_regulation MMP24 IL1B 10727770 678130 and TPA alone *induced* [MMP] activity in HIG-82 cells . Positive_regulation MMP24 IL1B 10864917 705851 and TNF-alpha each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP24 IL1B 10895370 711613 In support of this result , stimulation *induced* the expression of membrane type matrix-metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation MMP24 IL1B 11327259 807599 A decrease in IL-1alpha , , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP24 IL1B 11467889 840804 In all cases , PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on *induction* of [MMP] expression . Positive_regulation MMP24 IL1B 11997239 939303 produced a dose dependent *increase* in [MMP] activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min . Positive_regulation MMP24 IL1B 14872494 1208457 Preincubation with anti-CD44 antibody , which suppressed IL-1beta stimulated MMPs , reversed the inhibitory effect of HA on [MMP] production that was *induced* by in normal and OA cartilage . Positive_regulation MMP24 IL1B 16449361 1573882 HA at > or =2 mg/ml significantly inhibited [MMP] production *induced* by in a dose dependent manner . Positive_regulation MMP24 IL1B 16449361 1573904 Inhibition studies revealed the requirement of NF-kappaB , p38 and c-jun NH2-terminal kinase ( JNK ) for *induced* [MMP] production . Positive_regulation MMP24 IL1B 17328062 1711905 SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on *stimulated* [MMP] production and collagen degradation . Positive_regulation MMP24 IL1B 17925024 1835401 These findings demonstrate , for the first time , that glucosamine inhibits *stimulated* [MMP] production in human chondrocytes by affecting MAPK phosphorylation . Positive_regulation MMP24 IL1B 18403593 1899537 DHA significantly decreased VSMC migration/proliferation *induced* by as well as [fibrinolytic/MMP] activity . Positive_regulation MMP24 IL1B 18535174 1928804 *stimulated* [MMP] mRNA synthesis in wild-type , but not in IL-1RI-null cardiac fibroblasts . Positive_regulation MMP24 IL1B 19056796 2017721 Cordycepin is a potent inhibitor of *induced* chemokine production and [MMP] expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs . Positive_regulation MMP24 IL1B 19542681 2099204 *induced* [MMP] production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ) , p38 kinase , and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase (MAPK) family signal transduction molecules . Positive_regulation MMP24 IL1B 20403707 2282292 *induced* [MMP] production was significantly augmented in the presence of sIL-6R . Positive_regulation MMP24 IL1B 21344389 2480448 These findings establish CEBPB as a critical intermediate for dependent [MMP] gene *activation* and assign specific roles for the ERK and RSK kinases in this pathway . Positive_regulation MMP24 IL1B 22792188 2628389 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation MMP24 IL1B 9558121 500104 Recombinant TNF-alpha and added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP24 IL1B 9821179 548126 The inflammatory cytokine did not *induce* [MMP] or TIMP expression . Positive_regulation MMP24 IL1B 9890433 585423 A beta , but not or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells , as well as *increased* the expression of the well-known activator of MMP-2 , membrane-type ( MT ) [-MMP] . Positive_regulation MMP24 IL1B 9933437 589408 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by and TNF-alpha or down-regulated by IFN-gamma . Positive_regulation MMP24 MAP2K6 19833163 2196181 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP24 MAP2K6 20545600 2308475 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP24 MAP2K6 22310287 2719009 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP24 PODXL 17616675 1769340 These findings suggest that leads to increased in vitro migration and invasion , *increased* [MMP] expression , and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MMP24 TGM2 24130925 2714730 Gene silencing of *suppressed* the [MMP] expression by ATRA . Positive_regulation MMP24 TLR7 18802113 1964806 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP24 TNF 10482270 643786 We also examined the possibility that such MMPs could be produced by brain derived cells , and that [MMP] production by these cells might be *increased* by , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD . Positive_regulation MMP24 TNF 10864917 705850 IL-1beta and each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP24 TNF 11147175 760932 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that may *induce* [MMP] production followed by matrix degradation within foreign body granulomas . Positive_regulation MMP24 TNF 11773040 899409 Isolated RMVECs did not significantly increase [MMP] production directly in response to a hypoxic stimulus , but *required* the presence of exogenous . Positive_regulation MMP24 TNF 12113550 963873 Because elevation of COX-2 mRNA levels enhances the production of prostaglandins , we therefore investigated whether endogenous prostaglandins are involved in the [MMP] mRNA expression that is *enhanced* by . Positive_regulation MMP24 TNF 12606436 1064587 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP24 TNF 12909329 1121957 *mediates* the stretch induced [MMP] genes expression , at least in part , through the JNK pathway . Positive_regulation MMP24 TNF 14673992 1178646 The in vivo data clearly indicated that OSM + overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP24 TNF 15044327 1272767 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to dependent [MMP] *induction* in the macrophages . Positive_regulation MMP24 TNF 15184206 1280583 *causes* increased [MMP] production , but some increased MMP activity is present even in TNFRKO mice . Positive_regulation MMP24 TNF 15201935 1260870 IL-1 and are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP24 TNF 16549372 1582260 and OSM induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP24 TNF 17062332 1637233 To investigate the regulatory effects of fenofibrate on *induced* CD40 expression and [matrix metalloproteinase (MMP)] activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation MMP24 TNF 17469134 1737536 OSM and *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP24 TNF 17507431 1791867 Moreover , [MMP] activity in PCPEC supernatants was significantly *increased* by , presumably due to a diminished expression of TIMP-3 that was similarly observed . Positive_regulation MMP24 TNF 17876544 1796354 A similar augmentation was also observed in *induced* cytokine and [MMP] secretion . Positive_regulation MMP24 TNF 19026560 2001518 suppressed collagen type II and aggrecan , but *increased* [MMP] and cytokine expression in chondrocytes compared to the non stimulated controls . Positive_regulation MMP24 TNF 19435506 2106981 does not *induce* [MMP] expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation MMP24 TNF 20007453 2210596 We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since *induced* superoxide production , [MMP] expression , and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma . Positive_regulation MMP24 TNF 20403361 2267435 While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha , however , [matrix metalloproteinase (MMP)] *activation* of may also be contributory . Positive_regulation MMP24 TNF 23417988 2843314 SUMO-2/3 was knocked down using small interfering RNA in SFs , and *induced* [MMP] production was determined by ELISA . Positive_regulation MMP24 TNF 23417988 2843347 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by TNF-a and selectively control *mediated* [MMP] expression via the NF-?B pathway . Positive_regulation MMP24 TNF 23603294 2795190 Furthermore , infliximab effectively attenuated the *induced* increases in [MMP] expression in cells that make up the BAB . Positive_regulation MMP24 TNF 7543547 314351 Northern hybridization assays showed pretranslational control of PMA- , basic fibroblast growth factor- , and *induced* [MMP] expression . Positive_regulation MMP24 TNF 9014820 405421 In support of this result , stimulation *induced* membrane-type matrix metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation MMP24 TNF 9558121 500103 Recombinant and IL-1beta added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP24 TNF 9631748 512573 *increased* the total [MMP] activity released . Positive_regulation MMP24 TNF 9927150 588422 In general , *stimulated* both [MMP] and TIMP expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation MMP24 TNF 9933437 589407 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by IL-1beta and or down-regulated by IFN-gamma . Positive_regulation MMP25 CAPN8 21911754 2496852 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP25 CAPN8 21964156 2525630 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP25 CAPN8 22316244 2553136 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP25 CTGF 18632843 1979305 In conclusion , upregulation of inhibits BMP-7 signal transduction in the diabetic kidney and *contributes* to altered gene transcription , reduced [MMP] activity , glomerular basement membrane thickening , and albuminuria , all of which are hallmarks of diabetic nephropathy . Positive_regulation MMP25 EPHB2 14709335 1196624 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP25 EPHB2 20843518 2353053 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and *dependent* [MMP] expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation MMP25 EPHB2 24012928 2862319 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an [MMP] *inhibitor* , or PD98059 ( 50 µM ) , an inhibitor , also suppressed it . Positive_regulation MMP25 IGFBP1 15590975 1346143 Cell numbers were increased only by 100 nM IGFBP-1 isoforms ( P < 0.05 ) , whereas [MMP] levels released from term cells were optimally *increased* by 1-10 nM . Positive_regulation MMP25 IL1B 10727770 678091 and TPA alone *induced* [MMP] activity in HIG-82 cells . Positive_regulation MMP25 IL1B 10864917 705817 and TNF-alpha each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP25 IL1B 10895370 711574 In support of this result , stimulation *induced* the expression of membrane type matrix-metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation MMP25 IL1B 11327259 807548 A decrease in IL-1alpha , , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP25 IL1B 11467889 840787 In all cases , PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on *induction* of [MMP] expression . Positive_regulation MMP25 IL1B 11997239 939286 produced a dose dependent *increase* in [MMP] activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min . Positive_regulation MMP25 IL1B 14872494 1208440 Preincubation with anti-CD44 antibody , which suppressed IL-1beta stimulated MMPs , reversed the inhibitory effect of HA on [MMP] production that was *induced* by in normal and OA cartilage . Positive_regulation MMP25 IL1B 16449361 1573865 HA at > or =2 mg/ml significantly inhibited [MMP] production *induced* by in a dose dependent manner . Positive_regulation MMP25 IL1B 16449361 1573887 Inhibition studies revealed the requirement of NF-kappaB , p38 and c-jun NH2-terminal kinase ( JNK ) for *induced* [MMP] production . Positive_regulation MMP25 IL1B 17328062 1711888 SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on *stimulated* [MMP] production and collagen degradation . Positive_regulation MMP25 IL1B 17925024 1835163 These findings demonstrate , for the first time , that glucosamine inhibits *stimulated* [MMP] production in human chondrocytes by affecting MAPK phosphorylation . Positive_regulation MMP25 IL1B 18403593 1899520 DHA significantly decreased VSMC migration/proliferation *induced* by as well as [fibrinolytic/MMP] activity . Positive_regulation MMP25 IL1B 18535174 1928787 *stimulated* [MMP] mRNA synthesis in wild-type , but not in IL-1RI-null cardiac fibroblasts . Positive_regulation MMP25 IL1B 19056796 2017704 Cordycepin is a potent inhibitor of *induced* chemokine production and [MMP] expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs . Positive_regulation MMP25 IL1B 19542681 2099187 *induced* [MMP] production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ) , p38 kinase , and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase (MAPK) family signal transduction molecules . Positive_regulation MMP25 IL1B 20403707 2282275 *induced* [MMP] production was significantly augmented in the presence of sIL-6R . Positive_regulation MMP25 IL1B 21344389 2480431 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Positive_regulation MMP25 IL1B 22792188 2628261 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation MMP25 IL1B 9558121 500070 Recombinant TNF-alpha and added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP25 IL1B 9821179 548086 The inflammatory cytokine did not *induce* [MMP] or TIMP expression . Positive_regulation MMP25 IL1B 9890433 585406 A beta , but not or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells , as well as *increased* the expression of the well-known activator of MMP-2 , membrane-type ( MT ) [-MMP] . Positive_regulation MMP25 IL1B 9933437 589374 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by and TNF-alpha or down-regulated by IFN-gamma . Positive_regulation MMP25 MAP2K6 19833163 2196062 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP25 MAP2K6 20545600 2308349 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP25 MAP2K6 22310287 2718890 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP25 PODXL 17616675 1769310 These findings suggest that leads to increased in vitro migration and invasion , *increased* [MMP] expression , and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MMP25 TGM2 24130925 2714713 Gene silencing of *suppressed* the [MMP] expression by ATRA . Positive_regulation MMP25 TLR7 18802113 1964636 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP25 TNF 10482270 643769 We also examined the possibility that such MMPs could be produced by brain derived cells , and that [MMP] production by these cells might be *increased* by , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD . Positive_regulation MMP25 TNF 10864917 705816 IL-1beta and each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP25 TNF 11147175 760915 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that may *induce* [MMP] production followed by matrix degradation within foreign body granulomas . Positive_regulation MMP25 TNF 11773040 899392 Isolated RMVECs did not significantly increase [MMP] production directly in response to a hypoxic stimulus , but *required* the presence of exogenous . Positive_regulation MMP25 TNF 12113550 963856 Because elevation of COX-2 mRNA levels enhances the production of prostaglandins , we therefore investigated whether endogenous prostaglandins are involved in the [MMP] mRNA expression that is *enhanced* by . Positive_regulation MMP25 TNF 12606436 1064551 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP25 TNF 12909329 1121940 *mediates* the stretch induced [MMP] genes expression , at least in part , through the JNK pathway . Positive_regulation MMP25 TNF 14673992 1178612 The in vivo data clearly indicated that OSM + overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP25 TNF 15044327 1272750 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to dependent [MMP] *induction* in the macrophages . Positive_regulation MMP25 TNF 15184206 1280566 *causes* increased [MMP] production , but some increased MMP activity is present even in TNFRKO mice . Positive_regulation MMP25 TNF 15201935 1260836 IL-1 and are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP25 TNF 16549372 1582226 and OSM induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP25 TNF 17062332 1637216 To investigate the regulatory effects of fenofibrate on *induced* CD40 expression and [matrix metalloproteinase (MMP)] activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation MMP25 TNF 17469134 1737502 OSM and *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP25 TNF 17507431 1791850 Moreover , [MMP] activity in PCPEC supernatants was significantly *increased* by , presumably due to a diminished expression of TIMP-3 that was similarly observed . Positive_regulation MMP25 TNF 17876544 1796337 A similar augmentation was also observed in *induced* cytokine and [MMP] secretion . Positive_regulation MMP25 TNF 19026560 2001501 suppressed collagen type II and aggrecan , but *increased* [MMP] and cytokine expression in chondrocytes compared to the non stimulated controls . Positive_regulation MMP25 TNF 19435506 2106964 does not *induce* [MMP] expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation MMP25 TNF 20007453 2210579 We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since *induced* superoxide production , [MMP] expression , and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma . Positive_regulation MMP25 TNF 20403361 2267418 While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha , however , [matrix metalloproteinase (MMP)] *activation* of may also be contributory . Positive_regulation MMP25 TNF 23417988 2843297 SUMO-2/3 was knocked down using small interfering RNA in SFs , and *induced* [MMP] production was determined by ELISA . Positive_regulation MMP25 TNF 23417988 2843330 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by TNF-a and selectively control *mediated* [MMP] expression via the NF-?B pathway . Positive_regulation MMP25 TNF 23603294 2795173 Furthermore , infliximab effectively attenuated the *induced* increases in [MMP] expression in cells that make up the BAB . Positive_regulation MMP25 TNF 7543547 314334 Northern hybridization assays showed pretranslational control of PMA- , basic fibroblast growth factor- , and *induced* [MMP] expression . Positive_regulation MMP25 TNF 9014820 405404 In support of this result , stimulation *induced* membrane-type matrix metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation MMP25 TNF 9558121 500069 Recombinant and IL-1beta added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP25 TNF 9631748 512556 *increased* the total [MMP] activity released . Positive_regulation MMP25 TNF 9927150 588405 In general , *stimulated* both [MMP] and TIMP expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation MMP25 TNF 9933437 589373 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by IL-1beta and or down-regulated by IFN-gamma . Positive_regulation MMP26 CAPN8 21911754 2496866 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP26 CAPN8 21964156 2525644 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP26 CAPN8 22316244 2553150 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP26 CTGF 18632843 1979306 In conclusion , upregulation of inhibits BMP-7 signal transduction in the diabetic kidney and *contributes* to altered gene transcription , reduced [MMP] activity , glomerular basement membrane thickening , and albuminuria , all of which are hallmarks of diabetic nephropathy . Positive_regulation MMP26 EPHB2 14709335 1196626 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP26 EPHB2 20843518 2353054 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and *dependent* [MMP] expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation MMP26 EPHB2 24012928 2862320 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an [MMP] *inhibitor* , or PD98059 ( 50 µM ) , an inhibitor , also suppressed it . Positive_regulation MMP26 IGFBP1 15590975 1346144 Cell numbers were increased only by 100 nM IGFBP-1 isoforms ( P < 0.05 ) , whereas [MMP] levels released from term cells were optimally *increased* by 1-10 nM . Positive_regulation MMP26 IL1B 10727770 678092 and TPA alone *induced* [MMP] activity in HIG-82 cells . Positive_regulation MMP26 IL1B 10864917 705819 and TNF-alpha each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP26 IL1B 10895370 711575 In support of this result , stimulation *induced* the expression of membrane type matrix-metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation MMP26 IL1B 11327259 807551 A decrease in IL-1alpha , , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP26 IL1B 11467889 840788 In all cases , PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on *induction* of [MMP] expression . Positive_regulation MMP26 IL1B 11997239 939287 produced a dose dependent *increase* in [MMP] activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min . Positive_regulation MMP26 IL1B 14872494 1208441 Preincubation with anti-CD44 antibody , which suppressed IL-1beta stimulated MMPs , reversed the inhibitory effect of HA on [MMP] production that was *induced* by in normal and OA cartilage . Positive_regulation MMP26 IL1B 16449361 1573866 HA at > or =2 mg/ml significantly inhibited [MMP] production *induced* by in a dose dependent manner . Positive_regulation MMP26 IL1B 16449361 1573888 Inhibition studies revealed the requirement of NF-kappaB , p38 and c-jun NH2-terminal kinase ( JNK ) for *induced* [MMP] production . Positive_regulation MMP26 IL1B 17328062 1711889 SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on *stimulated* [MMP] production and collagen degradation . Positive_regulation MMP26 IL1B 17925024 1835177 These findings demonstrate , for the first time , that glucosamine inhibits *stimulated* [MMP] production in human chondrocytes by affecting MAPK phosphorylation . Positive_regulation MMP26 IL1B 18403593 1899521 DHA significantly decreased VSMC migration/proliferation *induced* by as well as [fibrinolytic/MMP] activity . Positive_regulation MMP26 IL1B 18535174 1928788 *stimulated* [MMP] mRNA synthesis in wild-type , but not in IL-1RI-null cardiac fibroblasts . Positive_regulation MMP26 IL1B 19056796 2017705 Cordycepin is a potent inhibitor of *induced* chemokine production and [MMP] expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs . Positive_regulation MMP26 IL1B 19542681 2099188 *induced* [MMP] production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ) , p38 kinase , and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase (MAPK) family signal transduction molecules . Positive_regulation MMP26 IL1B 20403707 2282276 *induced* [MMP] production was significantly augmented in the presence of sIL-6R . Positive_regulation MMP26 IL1B 21344389 2480432 These findings establish CEBPB as a critical intermediate for dependent [MMP] gene *activation* and assign specific roles for the ERK and RSK kinases in this pathway . Positive_regulation MMP26 IL1B 22792188 2628262 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation MMP26 IL1B 9558121 500072 Recombinant TNF-alpha and added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP26 IL1B 9821179 548087 The inflammatory cytokine did not *induce* [MMP] or TIMP expression . Positive_regulation MMP26 IL1B 9890433 585407 A beta , but not or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells , as well as *increased* the expression of the well-known activator of MMP-2 , membrane-type ( MT ) [-MMP] . Positive_regulation MMP26 IL1B 9933437 589376 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by and TNF-alpha or down-regulated by IFN-gamma . Positive_regulation MMP26 MAP2K6 19833163 2196069 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP26 MAP2K6 20545600 2308356 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP26 MAP2K6 22310287 2718897 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP26 PODXL 17616675 1769311 These findings suggest that leads to increased in vitro migration and invasion , *increased* [MMP] expression , and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MMP26 TGM2 24130925 2714714 Gene silencing of *suppressed* the [MMP] expression by ATRA . Positive_regulation MMP26 TLR7 18802113 1964646 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP26 TNF 10482270 643770 We also examined the possibility that such MMPs could be produced by brain derived cells , and that [MMP] production by these cells might be *increased* by , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD . Positive_regulation MMP26 TNF 10864917 705818 IL-1beta and each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP26 TNF 11147175 760916 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that may *induce* [MMP] production followed by matrix degradation within foreign body granulomas . Positive_regulation MMP26 TNF 11773040 899393 Isolated RMVECs did not significantly increase [MMP] production directly in response to a hypoxic stimulus , but *required* the presence of exogenous . Positive_regulation MMP26 TNF 12113550 963857 Because elevation of COX-2 mRNA levels enhances the production of prostaglandins , we therefore investigated whether endogenous prostaglandins are involved in the [MMP] mRNA expression that is *enhanced* by . Positive_regulation MMP26 TNF 12606436 1064553 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP26 TNF 12909329 1121941 *mediates* the stretch induced [MMP] genes expression , at least in part , through the JNK pathway . Positive_regulation MMP26 TNF 14673992 1178614 The in vivo data clearly indicated that OSM + overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP26 TNF 15044327 1272751 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to dependent [MMP] *induction* in the macrophages . Positive_regulation MMP26 TNF 15184206 1280567 *causes* increased [MMP] production , but some increased MMP activity is present even in TNFRKO mice . Positive_regulation MMP26 TNF 15201935 1260838 IL-1 and are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP26 TNF 16549372 1582228 and OSM induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP26 TNF 17062332 1637217 To investigate the regulatory effects of fenofibrate on *induced* CD40 expression and [matrix metalloproteinase (MMP)] activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation MMP26 TNF 17469134 1737504 OSM and *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP26 TNF 17507431 1791851 Moreover , [MMP] activity in PCPEC supernatants was significantly *increased* by , presumably due to a diminished expression of TIMP-3 that was similarly observed . Positive_regulation MMP26 TNF 17876544 1796338 A similar augmentation was also observed in *induced* cytokine and [MMP] secretion . Positive_regulation MMP26 TNF 19026560 2001502 suppressed collagen type II and aggrecan , but *increased* [MMP] and cytokine expression in chondrocytes compared to the non stimulated controls . Positive_regulation MMP26 TNF 19435506 2106965 does not *induce* [MMP] expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation MMP26 TNF 20007453 2210580 We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since *induced* superoxide production , [MMP] expression , and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma . Positive_regulation MMP26 TNF 20403361 2267419 While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha , however , [matrix metalloproteinase (MMP)] *activation* of may also be contributory . Positive_regulation MMP26 TNF 23417988 2843298 SUMO-2/3 was knocked down using small interfering RNA in SFs , and *induced* [MMP] production was determined by ELISA . Positive_regulation MMP26 TNF 23417988 2843331 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by TNF-a and selectively control *mediated* [MMP] expression via the NF-?B pathway . Positive_regulation MMP26 TNF 23603294 2795174 Furthermore , infliximab effectively attenuated the *induced* increases in [MMP] expression in cells that make up the BAB . Positive_regulation MMP26 TNF 7543547 314335 Northern hybridization assays showed pretranslational control of PMA- , basic fibroblast growth factor- , and *induced* [MMP] expression . Positive_regulation MMP26 TNF 9014820 405405 In support of this result , stimulation *induced* membrane-type matrix metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation MMP26 TNF 9558121 500071 Recombinant and IL-1beta added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP26 TNF 9631748 512557 *increased* the total [MMP] activity released . Positive_regulation MMP26 TNF 9927150 588406 In general , *stimulated* both [MMP] and TIMP expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation MMP26 TNF 9933437 589375 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by IL-1beta and or down-regulated by IFN-gamma . Positive_regulation MMP27 CAPN8 21911754 2496880 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP27 CAPN8 21964156 2525658 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP27 CAPN8 22316244 2553164 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP27 CTGF 18632843 1979307 In conclusion , upregulation of inhibits BMP-7 signal transduction in the diabetic kidney and *contributes* to altered gene transcription , reduced [MMP] activity , glomerular basement membrane thickening , and albuminuria , all of which are hallmarks of diabetic nephropathy . Positive_regulation MMP27 EPHB2 14709335 1196628 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP27 EPHB2 20843518 2353055 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and *dependent* [MMP] expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation MMP27 EPHB2 24012928 2862321 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an [MMP] *inhibitor* , or PD98059 ( 50 µM ) , an inhibitor , also suppressed it . Positive_regulation MMP27 IGFBP1 15590975 1346145 Cell numbers were increased only by 100 nM IGFBP-1 isoforms ( P < 0.05 ) , whereas [MMP] levels released from term cells were optimally *increased* by 1-10 nM . Positive_regulation MMP27 IL1B 10727770 678093 and TPA alone *induced* [MMP] activity in HIG-82 cells . Positive_regulation MMP27 IL1B 10864917 705821 and TNF-alpha each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP27 IL1B 10895370 711576 In support of this result , stimulation *induced* the expression of membrane type matrix-metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation MMP27 IL1B 11327259 807554 A decrease in IL-1alpha , , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP27 IL1B 11467889 840789 In all cases , PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on *induction* of [MMP] expression . Positive_regulation MMP27 IL1B 11997239 939288 produced a dose dependent *increase* in [MMP] activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min . Positive_regulation MMP27 IL1B 14872494 1208442 Preincubation with anti-CD44 antibody , which suppressed IL-1beta stimulated MMPs , reversed the inhibitory effect of HA on [MMP] production that was *induced* by in normal and OA cartilage . Positive_regulation MMP27 IL1B 16449361 1573867 HA at > or =2 mg/ml significantly inhibited [MMP] production *induced* by in a dose dependent manner . Positive_regulation MMP27 IL1B 16449361 1573889 Inhibition studies revealed the requirement of NF-kappaB , p38 and c-jun NH2-terminal kinase ( JNK ) for *induced* [MMP] production . Positive_regulation MMP27 IL1B 17328062 1711890 SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on *stimulated* [MMP] production and collagen degradation . Positive_regulation MMP27 IL1B 17925024 1835191 These findings demonstrate , for the first time , that glucosamine inhibits *stimulated* [MMP] production in human chondrocytes by affecting MAPK phosphorylation . Positive_regulation MMP27 IL1B 18403593 1899522 DHA significantly decreased VSMC migration/proliferation *induced* by as well as [fibrinolytic/MMP] activity . Positive_regulation MMP27 IL1B 18535174 1928789 *stimulated* [MMP] mRNA synthesis in wild-type , but not in IL-1RI-null cardiac fibroblasts . Positive_regulation MMP27 IL1B 19056796 2017706 Cordycepin is a potent inhibitor of *induced* chemokine production and [MMP] expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs . Positive_regulation MMP27 IL1B 19542681 2099189 *induced* [MMP] production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ) , p38 kinase , and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase (MAPK) family signal transduction molecules . Positive_regulation MMP27 IL1B 20403707 2282277 *induced* [MMP] production was significantly augmented in the presence of sIL-6R . Positive_regulation MMP27 IL1B 21344389 2480433 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Positive_regulation MMP27 IL1B 22792188 2628263 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation MMP27 IL1B 9558121 500074 Recombinant TNF-alpha and added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP27 IL1B 9821179 548088 The inflammatory cytokine did not *induce* [MMP] or TIMP expression . Positive_regulation MMP27 IL1B 9890433 585408 A beta , but not or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells , as well as *increased* the expression of the well-known activator of MMP-2 , membrane-type ( MT ) [-MMP] . Positive_regulation MMP27 IL1B 9933437 589378 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by and TNF-alpha or down-regulated by IFN-gamma . Positive_regulation MMP27 MAP2K6 19833163 2196076 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP27 MAP2K6 20545600 2308363 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP27 MAP2K6 22310287 2718904 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP27 PODXL 17616675 1769312 These findings suggest that leads to increased in vitro migration and invasion , *increased* [MMP] expression , and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MMP27 TGM2 24130925 2714715 Gene silencing of *suppressed* the [MMP] expression by ATRA . Positive_regulation MMP27 TLR7 18802113 1964656 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP27 TNF 10482270 643771 We also examined the possibility that such MMPs could be produced by brain derived cells , and that [MMP] production by these cells might be *increased* by , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD . Positive_regulation MMP27 TNF 10864917 705820 IL-1beta and each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP27 TNF 11147175 760917 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that may *induce* [MMP] production followed by matrix degradation within foreign body granulomas . Positive_regulation MMP27 TNF 11773040 899394 Isolated RMVECs did not significantly increase [MMP] production directly in response to a hypoxic stimulus , but *required* the presence of exogenous . Positive_regulation MMP27 TNF 12113550 963858 Because elevation of COX-2 mRNA levels enhances the production of prostaglandins , we therefore investigated whether endogenous prostaglandins are involved in the [MMP] mRNA expression that is *enhanced* by . Positive_regulation MMP27 TNF 12606436 1064555 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP27 TNF 12909329 1121942 *mediates* the stretch induced [MMP] genes expression , at least in part , through the JNK pathway . Positive_regulation MMP27 TNF 14673992 1178616 The in vivo data clearly indicated that OSM + overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP27 TNF 15044327 1272752 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to dependent [MMP] *induction* in the macrophages . Positive_regulation MMP27 TNF 15184206 1280568 *causes* increased [MMP] production , but some increased MMP activity is present even in TNFRKO mice . Positive_regulation MMP27 TNF 15201935 1260840 IL-1 and are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP27 TNF 16549372 1582230 and OSM induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP27 TNF 17062332 1637218 To investigate the regulatory effects of fenofibrate on *induced* CD40 expression and [matrix metalloproteinase (MMP)] activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation MMP27 TNF 17469134 1737506 OSM and *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP27 TNF 17507431 1791852 Moreover , [MMP] activity in PCPEC supernatants was significantly *increased* by , presumably due to a diminished expression of TIMP-3 that was similarly observed . Positive_regulation MMP27 TNF 17876544 1796339 A similar augmentation was also observed in *induced* cytokine and [MMP] secretion . Positive_regulation MMP27 TNF 19026560 2001503 suppressed collagen type II and aggrecan , but *increased* [MMP] and cytokine expression in chondrocytes compared to the non stimulated controls . Positive_regulation MMP27 TNF 19435506 2106966 does not *induce* [MMP] expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation MMP27 TNF 20007453 2210581 We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since *induced* superoxide production , [MMP] expression , and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma . Positive_regulation MMP27 TNF 20403361 2267420 While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha , however , [matrix metalloproteinase (MMP)] *activation* of may also be contributory . Positive_regulation MMP27 TNF 23417988 2843299 SUMO-2/3 was knocked down using small interfering RNA in SFs , and *induced* [MMP] production was determined by ELISA . Positive_regulation MMP27 TNF 23417988 2843332 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by TNF-a and selectively control *mediated* [MMP] expression via the NF-?B pathway . Positive_regulation MMP27 TNF 23603294 2795175 Furthermore , infliximab effectively attenuated the *induced* increases in [MMP] expression in cells that make up the BAB . Positive_regulation MMP27 TNF 7543547 314336 Northern hybridization assays showed pretranslational control of PMA- , basic fibroblast growth factor- , and *induced* [MMP] expression . Positive_regulation MMP27 TNF 9014820 405406 In support of this result , stimulation *induced* membrane-type matrix metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation MMP27 TNF 9558121 500073 Recombinant and IL-1beta added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP27 TNF 9631748 512558 *increased* the total [MMP] activity released . Positive_regulation MMP27 TNF 9927150 588407 In general , *stimulated* both [MMP] and TIMP expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation MMP27 TNF 9933437 589377 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by IL-1beta and or down-regulated by IFN-gamma . Positive_regulation MMP28 ABO 20049873 2200904 Our data indicated that depressed ROS with inhibition of NADPH oxidase instead of SOD activity , stimulated NO production and eNOS activation , and *restored* [MMP] in HUVECs . Positive_regulation MMP28 ADIPOQ 24255018 2904149 mediated APPL1-AMPK signaling *induces* cell migration , [MMP] activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation MMP28 AKT1 16142341 1451219 Inhibition of signaling in LM8 by a PI3K inhibitor , LY294002 , or by a dominant negative form of Akt , *resulted* in suppression of [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Positive_regulation MMP28 AKT1 16142341 1451321 In contrast , expression of an active form of in Dunn substantially *activated* its [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Positive_regulation MMP28 AKT1 21600739 2449894 The results indicate that GlcNAc *inhibited* UVB induced collagenolytic [MMP] production by interfering with Ca ( 2+ ) -dependent and MAPKs/AP-1 and NF-?B signaling . Positive_regulation MMP28 AKT1 24276246 2955822 This hPEBP4 potentiated cell invasion and [MMP] expression is *due* to an increase in activation . Positive_regulation MMP28 AKT2 16142341 1451220 Inhibition of signaling in LM8 by a PI3K inhibitor , LY294002 , or by a dominant negative form of Akt , *resulted* in suppression of [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Positive_regulation MMP28 AKT2 16142341 1451322 In contrast , expression of an active form of in Dunn substantially *activated* its [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Positive_regulation MMP28 AKT2 21600739 2449895 The results indicate that GlcNAc *inhibited* UVB induced collagenolytic [MMP] production by interfering with Ca ( 2+ ) -dependent and MAPKs/AP-1 and NF-?B signaling . Positive_regulation MMP28 AKT2 24276246 2955823 This hPEBP4 potentiated cell invasion and [MMP] expression is *due* to an increase in activation . Positive_regulation MMP28 AKT3 16142341 1451221 Inhibition of signaling in LM8 by a PI3K inhibitor , LY294002 , or by a dominant negative form of Akt , *resulted* in suppression of [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Positive_regulation MMP28 AKT3 16142341 1451323 In contrast , expression of an active form of in Dunn substantially *activated* its [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Positive_regulation MMP28 AKT3 21600739 2449896 The results indicate that GlcNAc *inhibited* UVB induced collagenolytic [MMP] production by interfering with Ca ( 2+ ) -dependent and MAPKs/AP-1 and NF-?B signaling . Positive_regulation MMP28 AKT3 24276246 2955824 This hPEBP4 potentiated cell invasion and [MMP] expression is *due* to an increase in activation . Positive_regulation MMP28 ANG 16103692 1454154 This study tested whether *induces* [MMP] in human vascular smooth muscle cells (SMC) . Positive_regulation MMP28 ANTXR2 22529944 2589690 functions in ECM homeostasis of the murine reproductive tract and *promotes* [MMP] activity . Positive_regulation MMP28 APAF1 22226830 2550064 Altogether , we have for the first time demonstrated the critical *role* of in the regulation of MAPK , ROS , and [MMP] in UVC radiated MEFs and propose that the amplification feedback loop among mitochondrial signal molecules culminates in the demise of the cell . Positive_regulation MMP28 APC 24574263 2938416 The induction of [MMP] *activation* and cartilage degradation by was dependent on its serine protease activity . Positive_regulation MMP28 APOB 15206153 1261272 Lectin-like oxidized LDL receptor-1 ( LOX-1 ) is a cell surface receptor for oxidized LDL , which is abundantly expressed in atherosclerotic plaques and is involved in oxidized *induced* [MMP] production and apoptosis . Positive_regulation MMP28 APPL1 24255018 2904150 Adiponectin mediated signaling *induces* cell migration , [MMP] activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation MMP28 ATF1 21505267 2448651 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or [Matrix Metalloproteinase (MMP)] . Positive_regulation MMP28 ATF2 21505267 2448652 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or [Matrix Metalloproteinase (MMP)] . Positive_regulation MMP28 ATF2 23466236 2766060 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of mitogen activated protein kinase (MAPK) , , and c-Jun , and [MMP] expression . Positive_regulation MMP28 ATF3 21505267 2448653 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or [Matrix Metalloproteinase (MMP)] . Positive_regulation MMP28 ATF4 21505267 2448654 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or [Matrix Metalloproteinase (MMP)] . Positive_regulation MMP28 ATF5 21505267 2448655 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or [Matrix Metalloproteinase (MMP)] . Positive_regulation MMP28 ATF6 21505267 2448656 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or [Matrix Metalloproteinase (MMP)] . Positive_regulation MMP28 ATF7 21505267 2448657 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or [Matrix Metalloproteinase (MMP)] . Positive_regulation MMP28 ATL1 19144404 2071380 is an aggressive disease characterized by visceral invasion , and ATL *regulates* [matrix metalloproteinase (MMP)] activities of the endothelial cells . Positive_regulation MMP28 ATL2 19144404 2071381 Adult T-cell leukemia (ATL) is an aggressive disease characterized by visceral invasion , and *regulates* [matrix metalloproteinase (MMP)] activities of the endothelial cells . Positive_regulation MMP28 ATL3 19144404 2071382 is an aggressive disease characterized by visceral invasion , and ATL *regulates* [matrix metalloproteinase (MMP)] activities of the endothelial cells . Positive_regulation MMP28 ATR 12207172 983482 Thus , the *induced* [MMP] and death of cultured liver cells are both inhibited by CsA as well as by glutathione ( GSH ) and enhanced by GSH depletion . Positive_regulation MMP28 BAX 12813466 1103216 The data reported herein indicate that LMP does not suffice to trigger caspase activation and that *dependent* [MMP] is a critical step of LMP induced cell death . Positive_regulation MMP28 BCL10 23091559 2690594 We found that dentatin mediated accumulation of reactive oxygen species ( ROS ) and downregulated expression levels of antiapoptotic molecules ( Bcl-2 , , and Survivin ) , *leading* to disruption of mitochondrial [membrane potential (MMP)] , cell membrane permeability , and release of cytochrome c from the mitochondria into the cytosol . Positive_regulation MMP28 BCL2 11067917 747132 Overexpression of *inhibited* TRAIL induced release of cytochrome c , changes in [MMP] , and apoptosis . Positive_regulation MMP28 BCL2 11960369 931588 BaxBH3Ant and *caused* a mitochondrial [membrane permeabilization (MMP)] and apoptosis , via a mechanism that was not inhibited by overexpressed Bcl-2 or Bcl-X ( L ) , yet partially inhibited by cyclosporin A ( CsA ) , an inhibitor of the mitochondrial permeability transition pore . Positive_regulation MMP28 BCL2 11960369 931610 When added to isolated mitochondria , BaxBH3 and *induced* [MMP] , which was inhibited by CsA . Positive_regulation MMP28 BCL2 11960369 931676 In purified mitochondria , two ligands of ANT , bongkrekic acid and the protein vMIA from cytomegalovirus , failed to prevent [MMP] *induced* by BaxBH3 or . Positive_regulation MMP28 BCL2 11960369 931698 In conclusion , BaxBH3 and *induce* [MMP] and apoptosis through a mechanism which overcomes cytoprotection by Bcl-2 and Bcl-X ( L ) . Positive_regulation MMP28 BCL2 15584904 1345442 Both a pseudosubstrate furin inhibitor , decanoyl-Arg-Val-Lys-Arg-chloromethylketone ( dec-RVKR-cmk ) , or alpha 1-anti-trypsin Portland ( PDX ) , a recombinant furin-inhibitory protein , suppress constitutive and *mediated* [MMP] activity and invasion . Positive_regulation MMP28 BCL2 17541305 1762452 Moreover , *induced* the expression of [MMP] in tumors grown in the orthotopic sites even though no appreciable effects were observed in the in vitro condition . Positive_regulation MMP28 BCL2 22419111 2572740 Pharmacologic inhibitors of the permeability transition pore , Bax/Bak inhibitors , and recombinant and Bcl-XL proteins do not *reduce* Tat induced [MMP] . Positive_regulation MMP28 BCL2 22491967 2613074 Second , we have highlighted that during etoposide or TNF-a treatments , intracellular ROS level , [MMP] and cell death are all *regulated* by caspases and , with caspases acting early in the process . Positive_regulation MMP28 BCL2 23091559 2690595 We found that dentatin mediated accumulation of reactive oxygen species ( ROS ) and downregulated expression levels of antiapoptotic molecules ( Bcl-2 , , and Survivin ) , *leading* to disruption of mitochondrial [membrane potential (MMP)] , cell membrane permeability , and release of cytochrome c from the mitochondria into the cytosol . Positive_regulation MMP28 BCL3 23091559 2690596 We found that dentatin mediated accumulation of reactive oxygen species ( ROS ) and downregulated expression levels of antiapoptotic molecules ( Bcl-2 , , and Survivin ) , *leading* to disruption of mitochondrial [membrane potential (MMP)] , cell membrane permeability , and release of cytochrome c from the mitochondria into the cytosol . Positive_regulation MMP28 BCL5 23091559 2690591 We found that dentatin mediated accumulation of reactive oxygen species ( ROS ) and downregulated expression levels of antiapoptotic molecules ( Bcl-2 , , and Survivin ) , *leading* to disruption of mitochondrial [membrane potential (MMP)] , cell membrane permeability , and release of cytochrome c from the mitochondria into the cytosol . Positive_regulation MMP28 BCL6 23091559 2690592 We found that dentatin mediated accumulation of reactive oxygen species ( ROS ) and downregulated expression levels of antiapoptotic molecules ( Bcl-2 , , and Survivin ) , *leading* to disruption of mitochondrial [membrane potential (MMP)] , cell membrane permeability , and release of cytochrome c from the mitochondria into the cytosol . Positive_regulation MMP28 BCL9 23091559 2690593 We found that dentatin mediated accumulation of reactive oxygen species ( ROS ) and downregulated expression levels of antiapoptotic molecules ( Bcl-2 , , and Survivin ) , *leading* to disruption of mitochondrial [membrane potential (MMP)] , cell membrane permeability , and release of cytochrome c from the mitochondria into the cytosol . Positive_regulation MMP28 BSG 11280798 798870 Purified native *induced* the production of secreted [MMP] not only by dermal fibroblasts ( MMP-1 ) but also by MDA-435 cells themselves ( MMP-2 ) , suggesting homophilic CD147 binding may occur in the context of both heterotypic and homotypic cell-cell interactions . Positive_regulation MMP28 BSG 15201341 1288961 It was shown previously that caveolin-1 associates with CD147 , thus inhibiting self-aggregation and [MMP] *induction* ; Positive_regulation MMP28 BSG 15201341 1288983 In addition , HG-CD147 ( but not LG-CD147 ) was preferentially captured as a multimer after treatment of cells with a homobifunctional cross linking agent and was exclusively recognized by monoclonal antibody AAA6 , a reagent that selectively recognizes self associated CD147 and inhibits mediated [MMP] *induction* . Positive_regulation MMP28 BSG 15319264 1303690 Additionally , oxLDLs might induce a circular upregulation of matrix degradation because , in turn , soluble *stimulates* [MMP] synthesis in HCA-SMC . Positive_regulation MMP28 BSG 15724816 1376887 *enhances* the secretion of [matrix metalloproteinases (MMP)] via cGMP/NO-sensitive capacitative calcium entry ( CCE ) and accordingly attenuates adhesion ability of fibroblasts . Positive_regulation MMP28 BSG 15781323 1385570 Later studies have shown that can also *induce* [MMP] in the same population of cells . Positive_regulation MMP28 BSG 15781323 1385592 The presence and modulation of EMMPRIN in normal tissues associated with increased MMP expression suggests that this *mediated* [MMP] induction could be a common mechanism in non-tumoral physiological and/or pathological situations . Positive_regulation MMP28 BSG 16207318 1464248 The *role* of in [MMP] production and cell invasion in vitro were studied through the co-culture of human CD14+ monocytes or monocytic line THP-1 cells and human fibroblasts , as well as by gel zymography and an invasion assay . Positive_regulation MMP28 BSG 16507143 1574167 The *role* of in [MMP] production and the cells ' invasiveness in vitro were studied by the co-culture of FLS with the human THP-1 cell line or monocytes/macrophages , by gel zymography and by invasion assay . Positive_regulation MMP28 BSG 16522689 1567950 The ability of to *stimulate* [MMP] secretion by endometrial fibroblasts indicates its potential role in uterine remodeling and the pathogenesis of endometriosis . Positive_regulation MMP28 BSG 17483329 1739040 The synergistic activities of the MCT/CD147 complex could facilitate migration of tumor cells by mediated [MMP] *induction* and lactate stimulated angiogenesis and hyaluronan production . Positive_regulation MMP28 BSG 17869266 1843026 Therefore , we tested the hypothesis that expression *regulates* [matrix metalloproteinase (MMP)] activity in rat ventricular myocytes in vitro . Positive_regulation MMP28 BSG 17869266 1843070 To determine whether expression *regulates* [matrix metalloproteinase (MMP)] activity , EMMPRIN activity was inhibited by adenoviral expression of an inhibitory mutant of EMMPRIN . Positive_regulation MMP28 BSG 17869266 1843158 The resulting increase in activity *stimulates* [MMP] expression and activity . Positive_regulation MMP28 BSG 18751374 1956292 Thus *regulates* migration , [MMP] production by SCC cells and deposition of the TN-C matrix . Positive_regulation MMP28 BSG 19003972 2016245 We have analysed the *role* of in the induction of [MMP] genes during mammary gland differentiation and involution . Positive_regulation MMP28 BSG 19003972 2016311 In summary the data argue against a causal *role* for for the induction of [MMP] gene expression during adult mammary gland development . Positive_regulation MMP28 BSG 19056510 2035451 Our studies which aimed to explore mechanisms of matrix degradation in pathological corneal wound healing have shown that , a glycoprotein expressed on corneal epithelial cell surface , can *induce* [matrix metalloproteinase (MMP)] production and myofibroblasts differentiation after direct interaction with corneal fibroblasts . Positive_regulation MMP28 BSG 20648565 2363084 In view of the [MMP] *inducing* function of , its role in myogenic cell differentiation was investigated . Positive_regulation MMP28 BSG 21536654 2440147 Overexpression of *inhibited* HCC cell proliferation , [MMP] induction , and cell invasion in vitro and in vivo . Positive_regulation MMP28 BSG 21637915 2450910 is a glycosylated transmembrane protein containing two immunoglobulin ( Ig ) domains that is expressed in carcinoma cells and *stimulates* [MMP] production by adjacent stromal cells . Positive_regulation MMP28 BSG 23005037 2716312 Moreover , native glycosylated existed exclusively as oligomers in solution and directly *stimulated* [MMP] production more efficiently than non glycosylated prokaryotic CD147 . Positive_regulation MMP28 BTRC 14981939 1182796 did not *enhance* [MMP] activity in any of the cell lines tested . Positive_regulation MMP28 C5 23287562 2769281 *increased* the release of [matrix metalloproteinases (MMP)] from cancer cells by two- to 11-fold , and inhibition of MMP activity abolished the C5a enhancing effect on cancer cell invasion . Positive_regulation MMP28 CAD 22127696 2514917 stimulation *increased* RA synovial fibroblast [MMP] messenger RNA levels . Positive_regulation MMP28 CALML3 12909586 1157486 In conclusion , exposing TIMP-3 null animals to sepsis rapidly enhances the phenotypic abnormalities of these mice , due to increased [MMP] activity *induced* by . Positive_regulation MMP28 CAPN1 21911754 2496900 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP28 CAPN1 21964156 2525678 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP28 CAPN1 22316244 2553184 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP28 CAPN10 21911754 2496901 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP28 CAPN10 21964156 2525679 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP28 CAPN10 22316244 2553185 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP28 CAPN11 21911754 2496902 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP28 CAPN11 21964156 2525680 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP28 CAPN11 22316244 2553186 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP28 CAPN12 21911754 2496899 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP28 CAPN12 21964156 2525677 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP28 CAPN12 22316244 2553183 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP28 CAPN13 21911754 2496910 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP28 CAPN13 21964156 2525688 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP28 CAPN13 22316244 2553194 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP28 CAPN14 21911754 2496911 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP28 CAPN14 21964156 2525689 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP28 CAPN14 22316244 2553195 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP28 CAPN15 21911754 2496898 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP28 CAPN15 21964156 2525676 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP28 CAPN15 22316244 2553182 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP28 CAPN2 21911754 2496903 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP28 CAPN2 21964156 2525681 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP28 CAPN2 22316244 2553187 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP28 CAPN3 21911754 2496904 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP28 CAPN3 21964156 2525682 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP28 CAPN3 22316244 2553188 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP28 CAPN5 21911754 2496905 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP28 CAPN5 21964156 2525683 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP28 CAPN5 22316244 2553189 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP28 CAPN6 21911754 2496906 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP28 CAPN6 21964156 2525684 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP28 CAPN6 22316244 2553190 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP28 CAPN7 21911754 2496907 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP28 CAPN7 21964156 2525685 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP28 CAPN7 22316244 2553191 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP28 CAPN8 21911754 2496908 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP28 CAPN8 21964156 2525686 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP28 CAPN8 22316244 2553192 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP28 CAPN9 21911754 2496909 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP28 CAPN9 21964156 2525687 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP28 CAPN9 22316244 2553193 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP28 CARM1 18511550 1951902 Furthermore , we show that also *regulates* [MMP] expression at the post-transcriptional level , either positively or negatively . Positive_regulation MMP28 CASP1 11067917 747205 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP28 CASP1 19593672 2224172 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP28 CASP10 11067917 747206 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP28 CASP10 19593672 2224173 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP28 CASP12 11067917 747216 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP28 CASP12 19593672 2224183 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP28 CASP14 11067917 747207 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP28 CASP14 19593672 2224174 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP28 CASP16 11067917 747217 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP28 CASP16 19593672 2224184 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP28 CASP2 11067917 747208 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP28 CASP2 19593672 2224175 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP28 CASP3 11067917 747209 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP28 CASP3 12750841 1107398 As ( 2 ) O ( 3 ) induced apoptosis in parent MOLT-4 cells and MOLT-4/DNR cells expressing functional P-gp via depletion of intracellular GSH , and subsequent disruption of [MMP] and *activation* of . Positive_regulation MMP28 CASP3 16877372 1625514 Using cell culture assay model , we revealed in our results that ginkgolide B treatment of ESCs ( ESC-B5 ) induced apoptosis via reactive oxygen species ( ROS ) generation , c-Jun N-terminal kinase (JNK) activation , loss of mitochondrial [membrane potential (MMP)] and the *activation* of . Positive_regulation MMP28 CASP3 17331071 1733789 Experiments in embryonic stem cells ( ESC-B5 ) showed that CTN induces apoptosis via ROS ( reactive oxygen species ) generation , increased Bax/Bcl-2 ratio , loss of [MMP] ( mitochondrial membrane potential ) , induction of cytochrome c release , and *activation* of . Positive_regulation MMP28 CASP3 17573851 1903004 Apoptosis signalling was monitored by assessment of EPS , disruption of [MMP] and *activation* of by flow cytometry . Positive_regulation MMP28 CASP3 18313257 1978929 The sulforaphane induced apoptosis in U937 cells correlated with the generation of intracellular ROS , collapse of [MMP] , *activation* of , and down-regulation of anti-apoptotic Bcl-2 expression . Positive_regulation MMP28 CASP3 18804340 2028408 However , the quenching of ROS generation in response to treatment with a ROS scavenger , N-acetyl-L-cysteine , reversed the platycodon D-induced apoptosis effects via inhibition of Egr-1 activation , ROS production , [MMP] collapse , and the subsequent *activation* of . Positive_regulation MMP28 CASP3 19047834 1999207 The results of this study demonstrated that streptochlorin mediates ROS production , and that this mediation is followed by a decrease in the mitochondrial membrane potential ( [MMP] , m ) , *activation* of , and downregulation of antiapoptotic Bcl-2 protein . Positive_regulation MMP28 CASP3 19047834 1999230 The quenching of ROS generation by N-acetyl-L-cysteine administration , a scavenger of ROS , reversed the streptochlorin induced apoptosis effects via inhibition of ROS production , [MMP] collapse , and the subsequent *activation* of . Positive_regulation MMP28 CASP3 19259823 2072608 Significant enhancement of Fas externalization , loss of mitochondrial [membrane potential (MMP)] , and *activation* of and caspase-8 were observed after the combined treatment . Positive_regulation MMP28 CASP3 19593672 2224176 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP28 CASP3 19736292 2152741 Pre-treatment with broad-spectrum caspase inhibitor Z-VAD-FMK , inhibitor Ac-DEVD-CHO and caspase-8 inhibitor Z-IETD-FMK *prevented* the change in [MMP] and DNA fragmentation , suggesting caspase dependent apoptosis of rYopJ treated macrophages . Positive_regulation MMP28 CASP3 19944168 2198891 At 8 h and 12 h p.i. , IPNV infected cells demonstrated a dramatic increase in [MMP] loss , rapid entry into necrotic cell death , and *activation* of . Positive_regulation MMP28 CASP3 20111678 2178677 In the present study , we examined the effects of resveratrol on apoptotic biochemical events in Hep G2 cells induced by CTN. Resveratrol inhibited CTN induced ROS generation , activation of JNK , loss of mitochondrial [membrane potential (MMP)] , as well as *activation* of caspase-9 , and PAK2 . Positive_regulation MMP28 CASP3 20147844 2242423 Separate in vitro studies demonstrated that activated caspase species cleaved pro-MMP-2 yielding active MMP-2 forms and that [MMP] activity was increased in the *presence* of activated . Positive_regulation MMP28 CASP3 21334318 2415178 Cafestol induced apoptosis is associated with the reduction of mitochondrial [membrane potential (MMP)] , *activation* of , cytochrome c release , and down-regulation of anti-apoptotic proteins ( Bcl-2 , Bcl-xL , Mcl-1 and cFLIP ) . Positive_regulation MMP28 CASP3 21595920 2445648 Curcumin induced apoptosis was associated with reduced expression of both Bcl-2 mRNA and protein , subsequent loss of [MMP] , and *activation* of followed by PARP degradation . Positive_regulation MMP28 CASP3 21656837 2532034 Furthermore , increase of ROS , loss of [MMP] , *activation* of , and down-regulation of Bcl-2 expression was observed . Positive_regulation MMP28 CASP3 21723035 2461004 TMEM14A prevented 4-HPR induced loss of mitochondrial [membrane potential (MMP)] , the release of cytochrome c , and the *activation* of , but not the generation of reactive oxygen species , suggesting that TMEM14A regulates mitochondrial membrane potential in a ROS independent manner . Positive_regulation MMP28 CASP3 21793156 2803040 Further investigation of these processes revealed that MG directly promotes reactive oxygen species ( ROS ) generation , loss of mitochondrial [membrane potential (MMP)] , and *activation* of , whereas resveratrol effectively blocks MG-induced ROS production and the accompanying apoptotic biochemical changes . Positive_regulation MMP28 CASP3 21865727 2473432 The apoptosis of AML cells after 4-AP treatment was further confirmed by the disruption of mitochondrial [membrane potential (MMP)] and *activation* of and 9 . Positive_regulation MMP28 CASP3 22449440 2582975 Furthermore , the overexpression of Bcl-xL significantly prevented FRAP induced apoptosis , [MMP] changes , and the *activations* of , -8 , and -9 . Positive_regulation MMP28 CASP3 23660334 2795994 Sanguinarine generated ROS , which was followed by a decrease in the mitochondrial [membrane potential (MMP)] , the *activation* of , and the down-regulation of anti-apoptotic proteins , such as Bcl2 , XIAP and cIAP-1 . Positive_regulation MMP28 CASP3 24098753 2852309 Furthermore , our results revealed that induction of apoptosis through a mitochondrial pathway led to up-regulation of pro-apoptotic protein expression ( Bax ) , down-regulation of anti-apoptotic protein expression ( Bcl-2 ) , mitochondrial release of cytochrome c (Cyto c) , reduction of mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP28 CASP3 24335836 2895049 Consistently , bornyl caffeate increased Bax and decreased Bcl-xl , resulting in the disruption of [MMP] and subsequent *activation* of . Positive_regulation MMP28 CASP4 11067917 747210 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP28 CASP4 19593672 2224177 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP28 CASP5 11067917 747211 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP28 CASP5 19593672 2224178 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP28 CASP6 11067917 747212 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP28 CASP6 19593672 2224179 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP28 CASP7 11067917 747213 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP28 CASP7 19593672 2224180 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP28 CASP8 11067917 747214 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP28 CASP8 19259823 2072609 Significant enhancement of Fas externalization , loss of mitochondrial [membrane potential (MMP)] , and *activation* of caspase-3 and were observed after the combined treatment . Positive_regulation MMP28 CASP8 19593672 2224181 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP28 CASP9 11067917 747215 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP28 CASP9 15557813 1340908 We also observed ceramide/ DMS induced disruption of mitochondrial [membrane potential (MMP)] and *activation* of and -3 in a radiation-dose dependent manner . Positive_regulation MMP28 CASP9 19593672 2224182 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP28 CASP9 19944168 2198892 At 8 h and 12 h p.i. , IPNV infected cells demonstrated a dramatic increase in [MMP] loss , rapid entry into necrotic cell death , and *activation* of and -3 . Positive_regulation MMP28 CASP9 23660334 2795995 Sanguinarine generated ROS , which was followed by a decrease in the mitochondrial [membrane potential (MMP)] , the *activation* of and -3 , and the down-regulation of anti-apoptotic proteins , such as Bcl2 , XIAP and cIAP-1 . Positive_regulation MMP28 CAT 23352441 2747564 Phagocytosis , the loss of [MMP] , autophagy and the activated signaling pathways were all *suppressed* by ROS scavenger N-acetyl-l-cysteine (NAC) , H2O2 scavenger or OH scavenger glutathione ( GSH ) . Positive_regulation MMP28 CCDC88A 23568586 2810246 Pretreatment with doxycycline blunted *induced* increases in RV myocardial ROS concentrations and [MMP] gelatinolytic activity ( both P < 0.05 ) . Positive_regulation MMP28 CCL19 17170367 1694855 and CCL21 promoted an inflammatory phenotype in T-cells and macrophages and *increased* [matrix metalloproteinase (MMP)] and tissue factor levels in the latter cell type . Positive_regulation MMP28 CCL21 17170367 1694856 CCL19 and promoted an inflammatory phenotype in T-cells and macrophages and *increased* [matrix metalloproteinase (MMP)] and tissue factor levels in the latter cell type . Positive_regulation MMP28 CD40 15290728 1278576 interaction *augments* the expression of inflammatory cytokines and [MMP] in chondrocytes and contributes to an intrinsic process of cartilage degradation in RA . Positive_regulation MMP28 CD40 17949416 1894417 Finally , we investigated whether interactions were *involved* in T-cell stimulated [MMP] secretion from macrophages . Positive_regulation MMP28 CD40LG 15290728 1278577 interaction *augments* the expression of inflammatory cytokines and [MMP] in chondrocytes and contributes to an intrinsic process of cartilage degradation in RA . Positive_regulation MMP28 CD40LG 9933437 589351 Therefore , we analysed the *induced* [MMP] production by these fibroblasts in the presence of cytokines that are increased in periodontal lesions , such as IL-1beta , tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) . Positive_regulation MMP28 CDC73 23911909 2840314 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Positive_regulation MMP28 CDH11 22127696 2514827 The objective of this study was to determine if synovial fibroblast [MMP] production is *regulated* by . Positive_regulation MMP28 CDH11 22127696 2514939 These results underscore the existence of a pathway by which *regulates* [MMP] production and has important implications for joint destruction in RA . Positive_regulation MMP28 CDK2 21822799 2462992 Ectopic expression of the dominant negative ( Cdk2-dn ) and a specific Cdk2 inhibitor , p21 ( WAF1/CIP1 ) , effectively *suppresses* the loss of [MMP] , the release of cytochrome c , and subsequent activation of caspase-3 in paclitaxel treated cells . Positive_regulation MMP28 CHMP2A 11960369 931654 However , Bcl-2 or Bcl-X ( L ) failed to inhibit [MMP] *induced* by BaxBH3 and in vitro , while they efficiently suppressed the induction of MMP by the Vpr protein ( from human immunodeficiency virus-1 ) , a ligand of the adenine nucleotide translocator ( ANT ) . Positive_regulation MMP28 CITED2 12960175 1164244 Using the immortalized human chondrocyte cell line , C-28/I2 , we investigated whether could be responsive to mechanical stimuli , and if so , whether CITED2 could *mediate* shear-driven regulation of [matrix metalloproteinase (MMP)] genes . Positive_regulation MMP28 COL1A1 16004981 1452899 Since previous studies have demonstrated that interaction of interstitial fibroblasts with high molecular weight fragments of *leads* to increased [MMP] production , the present results suggest a mechanism underlying altered function of stromal elements in the connective tissue adjacent to the growing neoplasm . Positive_regulation MMP28 COL1A2 16004981 1452900 Since previous studies have demonstrated that interaction of interstitial fibroblasts with high molecular weight fragments of *leads* to increased [MMP] production , the present results suggest a mechanism underlying altered function of stromal elements in the connective tissue adjacent to the growing neoplasm . Positive_regulation MMP28 CPOX 20654727 2340554 The inhibitors of and/or LOX could *inhibit* cell proliferation , [MMP] activity and invasion in head and neck and colon cancer cells . Positive_regulation MMP28 CRP 16580524 1543672 stimulation also *increased* MMP-1 and -10 protein in conditioned culture medium ( p < 0.001 ) , as well as [MMP] activity ( p = 0.001 ) . Positive_regulation MMP28 CSE 15096214 1238770 VIP , at 10 ( -7 ) m , reduced *stimulated* [MMP] activity and caspase-3 activation . Positive_regulation MMP28 CSF2 15363038 1293893 *activates* RhoA , integrin and [MMP] expression in human monocytic cells . Positive_regulation MMP28 CSF2 9610697 508803 also *increased* the [MMP] activity of LK-2 and LC-1 cells . Positive_regulation MMP28 CSRP1 18245817 1890632 *promotes* OxLDL uptake and [MMP] induction in vitro ; Positive_regulation MMP28 CTGF 18632843 1979309 In conclusion , upregulation of inhibits BMP-7 signal transduction in the diabetic kidney and *contributes* to altered gene transcription , reduced [MMP] activity , glomerular basement membrane thickening , and albuminuria , all of which are hallmarks of diabetic nephropathy . Positive_regulation MMP28 CTNNB1 15313922 1285753 Because can *regulate* [MMP] expression , we investigated the expression of several MMPs and TIMPs in aggressive fibromatosis tumors that develop in Apc+/Apc1638N mice . Positive_regulation MMP28 CTR9 23911909 2840315 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Positive_regulation MMP28 CUL1 14981939 1182797 did not *enhance* [MMP] activity in any of the cell lines tested . Positive_regulation MMP28 DDC 16638095 1552874 *activated* PSC , increasing the number of alpha-SMA positive cells , enhancing secretion of type I collagen and [MMP] , inhibiting PSC proliferation . Positive_regulation MMP28 DEFA1 21896310 2486992 The results showed that adenosine triphosphate ( ATP ) and mitochondrial [membrane potential (MMP)] in the astrocytes were up-regulated in the presence of ADP , which could be *enhanced* by , a specific antagonist for P2Y(1) receptor . Positive_regulation MMP28 DFFB 22127696 2514873 This up-regulation required cell cadherin 11 engagement , since a mutant with reduced binding affinity *stimulated* significantly less [MMP] production . Positive_regulation MMP28 DFFB 22127696 2514895 Also , short hairpin RNA ( shRNA ) cadherin 11 silencing almost completely inhibited *induced* [MMP] expression . Positive_regulation MMP28 EDN1 12842810 1149595 Thus early changes in *mediated* regulation of [MMP] activity were measured in borderline hypertensive rats that develop impaired vasorelaxation and hypertension with chronic exposure to stress . Positive_regulation MMP28 EDN1 12875994 1115279 Combined addition of both ET ( B ) receptor ( ET ( B ) R ) and ET ( A ) R antagonists completely blocked the *induced* [MMP] activity . Positive_regulation MMP28 EDN1 14558091 1153679 Recently , it was suggested that , a potent vasoconstrictor , may be *involved* in [MMP] regulation . Positive_regulation MMP28 EDNRA 12842810 1149529 Recent studies demonstrated that receptors *regulate* cardiac [MMP] activity and fibrosis in DOCA-salt hypertension . Positive_regulation MMP28 EGF 10398277 627903 *Induction* of the [MMP] , matrilysin , by was investigated in a human prostate cancer cell line . Positive_regulation MMP28 EGF 15780084 1385225 These responses which are dependent on its protease activity appear not to be mediated by PAR-1 activation , the autocrine action of thrombin induced TGF-beta1 secretion , [MMP] activation , or receptor *transactivation* . Positive_regulation MMP28 EGF 16394028 1553993 EGF withdrawal resulted in a more epithelial morphology and reversal of the *induced* activation of signaling pathways and [pro-MMP] activity . Positive_regulation MMP28 EGF 24744893 2936367 Here , we examined the role of *mediated* [matrix metalloproteinases (MMP)] on the stability of interstitial collagens in vascular smooth muscle cells ( VSMCs ) isolated from carotid endarterectomy tissues of symptomatic and asymptomatic patients with carotid stenosis . Positive_regulation MMP28 EGFR 12421825 1036432 Targeting of only the E domain of ERalpha to the plasma membrane resulted in [MMP] activation and *transactivation* . Positive_regulation MMP28 EGFR 16289596 1546832 In these experiments we used an inhibitor , AG1478 or [matrix metalloproteinase (MMP)] *inhibitor* , GM6001 . Positive_regulation MMP28 EGFR 17348021 1748190 Here we provide genetic and biochemical evidence that and AP-1 mediated signals are *required* for [MMP] expression and collagen contraction in fibroblasts . Positive_regulation MMP28 EGFR 20889674 2353421 To explore the EGFR signaling pathway , we used a broad-spectrum [matrix metalloproteinase (MMP)] *inhibitor* , GM-6001 , two selective tyrosine kinase inhibitors , AG-1478 and PD-153035 , an HB-EGF neutralizing antibody , and a specific small interfering RNA ( siRNA ) against the EGFR . Positive_regulation MMP28 EGFR 23644655 2926241 We demonstrated that macrophages stimulate cancer cell invasion , motility and migration , and that these effects depend on [matrix metalloproteinase (MMP)] activity and on the *activation* of ( at the residue Y ( 1086 ) ) , PLC-? ( phospholipase C-gamma ) and Gab1 ( GRB2 associated binding protein-1 ) , as evidenced by siRNA ( small interference RNA ) experiments . Positive_regulation MMP28 EPHB2 14709335 1196632 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP28 EPHB2 20843518 2353057 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and *dependent* [MMP] expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation MMP28 EPHB2 24012928 2862323 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an [MMP] *inhibitor* , or PD98059 ( 50 µM ) , an inhibitor , also suppressed it . Positive_regulation MMP28 EPX 21461559 2412786 Specifically , we studied whether combined with G-CSF *enhanced* [MMP] expression and increased the in vitro motility of MSCs . Positive_regulation MMP28 ERVK-6 16772705 1572824 In addition , the proteolytic activity was almost completely inhibited by BS-10 , a [MMP] *inhibitor* , but not by the serine proteinase inhibitors , cysteine proteinase inhibitors and aspartic inhibitors . Positive_regulation MMP28 ERVK-6 8698831 375322 These results suggested that during ischemic cardiomyopathy , initially neutrophil *activates* latent myocardial [MMP] which can degrade ECM , which continuously degrades if not controlled by TIMP , leading to ventricular dilatation and dysfunction . Positive_regulation MMP28 ETS1 18181172 1889979 Moreover , concomitantly *triggered* [matrix metalloproteinases (MMP)] expression and activation , thus contributing to cell scattering . Positive_regulation MMP28 ETV4 10836994 698062 We have previously reported that the Ets-oncogene family transcription factor positively *regulates* transcription of [MMP] genes in transient expression assays and that overexpression of the E1AF gene confers an invasive phenotype on breast cancer cells . Positive_regulation MMP28 ETV4 9197532 438569 The ets transcription factor can *activate* several [matrix degrading metalloproteinase (MMP)] genes and is implicated in enhancement of tumor cell invasion . Positive_regulation MMP28 FABP3 22528395 2602380 The results revealed that downregulated expression promoted apoptosis , and resulted in mitochondrial deformation , *increased* mitochondrial [membrane potential (MMP)] , and decreased intracellular ATP synthesis . Positive_regulation MMP28 FGF2 9858899 555696 The CAPL protein expressed in cell-cultures appear to block the [MMP] *induction* by and Il-1 alpha . Positive_regulation MMP28 FLT1 9776730 540185 These data suggest the *role* of in mediating VEGF stimulated [MMP] expression of SMCs . Positive_regulation MMP28 FN1 11134254 769459 In addition , [MT-MMP] activity , selectively *induced* by , was implicated in the activation of the secreted proteinases . Positive_regulation MMP28 FN1 16788844 1577621 In this present communication , we cultured human cervical cancer cells , SiHa , in the presence of fibronectin to study *mediated* modulation of [MMP] activity . Positive_regulation MMP28 FN1 17341207 1664995 In this present study , we cultured human fibrosarcoma cells , HT-1080 , in presence of fibronectin to study *mediated* modulation of [MMP] activity . Positive_regulation MMP28 FN1 18243246 1871476 Blocking of alpha5beta 1 integrin with anti-alpha5 monoclonal antibody inhibits the *induced* [MMP] activation response appreciably . Positive_regulation MMP28 FN1 18396067 1958048 To define the role of mitogen activated protein ( MAP ) kinases in *mediated* [matrix metalloproteinase (MMP)] upregulation and damage to bovine cartilage and to compare activities of three Fn-fs with native fibronectin (Fn) , which is inactive in terms of cartilage damage . Positive_regulation MMP28 FN1 18540849 1923469 In this present work , we cultured human A375 melanoma cells in the presence of fibronectin to study *mediated* modulation of [MMP] activity . Positive_regulation MMP28 FN1 20224727 2223595 In the present communication we cultured K562 cells in *presence* of to study the fibronectin-integrin mediated signalling and modulation of [MMP] expression . Positive_regulation MMP28 FNTA 10811109 692857 Similarly , a Ras inhibitor , manumycin A , and a MEK1 inhibitor , U0126 , *suppressed* [MMP] secretion in a dose dependent manner , whereas a PI3 kinase inhibitor , wortmannin , could not . Positive_regulation MMP28 FNTB 10811109 692858 Similarly , a Ras inhibitor , manumycin A , and a MEK1 inhibitor , U0126 , *suppressed* [MMP] secretion in a dose dependent manner , whereas a PI3 kinase inhibitor , wortmannin , could not . Positive_regulation MMP28 FURIN 12803542 1140915 Expression of the 58 kDa form was increased by a synthetic furin inhibitor at the expense of the 48 kDa form , suggesting that cleaves and *activates* [epilysin] . Positive_regulation MMP28 FURIN 15584904 1345441 Both a pseudosubstrate inhibitor , decanoyl-Arg-Val-Lys-Arg-chloromethylketone ( dec-RVKR-cmk ) , or alpha 1-anti-trypsin Portland ( PDX ) , a recombinant furin-inhibitory protein , *suppress* constitutive and BCL-2 mediated [MMP] activity and invasion . Positive_regulation MMP28 FURIN 18392131 1893490 Here , we show that this cell-permeable , small-molecule compound inhibits *mediated* cleavage of [proMT1-MMP] , resulting in decreased MMP-2 activation and cell motility in CHO cells expressing proMT1-MMP . Positive_regulation MMP28 GAB1 23644655 2926242 We demonstrated that macrophages stimulate cancer cell invasion , motility and migration , and that these effects depend on [matrix metalloproteinase (MMP)] activity and on the *activation* of epidermal growth factor receptor (EGFR) ( at the residue Y ( 1086 ) ) , PLC-? ( phospholipase C-gamma ) and ( GRB2 associated binding protein-1 ) , as evidenced by siRNA ( small interference RNA ) experiments . Positive_regulation MMP28 GAL 18080343 1889624 The presence of onto the polymer surface *increased* both cell adhesion , spreading and proliferation along with MMP-9 and [MMP-28] production , suggesting that polymer functionalization using GAL could be an useful tool for the production of an artificial epidermis . Positive_regulation MMP28 GIT1 19023093 2022642 Therefore , *mediates* VEGF induced [matrix metalloproteinase (MMP)] activation and ECM degradation by regulating podosome formation . Positive_regulation MMP28 GLRX 18560520 1924098 Our studies demonstrate that , a cytosolic oxido-reductase , helps maintain mitochondrial integrity and *prevents* [MMP] loss caused by oxidative insult . Positive_regulation MMP28 GNRH1 17108127 1645173 Knockdown of the GnRH receptor using small interfering RNA significantly inhibited the *induced* [MMP] activation , invasion , and migration . Positive_regulation MMP28 GNRH1 17108127 1645248 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 mitogen activated protein kinase , signaling pathway was critical for *mediated* up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP28 GPR65 23707809 2801532 The *induction* of [MMP] expression by was further confirmed in A549 and/or FaDu cells . Positive_regulation MMP28 GPR65 23707809 2801554 *mediated* [MMP] induction under acidic conditions . Positive_regulation MMP28 HDAC1 12810630 1102741 In this study , we test the possibility that inhibitor may increase RECK expression to *inhibit* [MMP] activation and cancer cell invasion . Positive_regulation MMP28 HDAC1 20144149 2236024 Transient transfection assays have shown that the *induction* of [MMP28] expression by the inhibitior TSA ( trichostatin A ) is mediated via Sp1 at the GT-box . Positive_regulation MMP28 HDAC2 12810630 1102742 In this study , we test the possibility that inhibitor may increase RECK expression to *inhibit* [MMP] activation and cancer cell invasion . Positive_regulation MMP28 HDAC2 20144149 2236025 Transient transfection assays have shown that the *induction* of [MMP28] expression by the inhibitior TSA ( trichostatin A ) is mediated via Sp1 at the GT-box . Positive_regulation MMP28 HDAC4 20847282 2325726 Furthermore , ectopic expression of in quiescent HSCs *results* in repression of [MMP] promoter activities as well as endogenous MMP9 protein expression . Positive_regulation MMP28 HGF 10860849 704953 *enhances* [MMP] activity in human endothelial cells . Positive_regulation MMP28 HGF 12606436 1064560 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by tumor necrosis factor alpha (TNFalpha) , IL-6 , , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP28 HGF 16998831 1640839 Conversely , the elevated cancer invasion , [MMP] activity and c-Met phosphorylation of PK8 cells were *reduced* by the removal of from hypoxic conditioned medium . Positive_regulation MMP28 HGF 21292466 2489312 *promoted* cell proliferation , migration , invasion and induction of [MMP] ( matrix metalloproteinase)-2 and MMP-9 in KB cells . Positive_regulation MMP28 HGF 9759374 536345 After 24 or 48 h of culture in medium supplemented with HGF , transforming growth factor-alpha ( TGF-alpha ) or sodium butyrate , [MMP] production by DHD/K12 cells was *stimulated* by and TGF-alpha and inhibited by sodium butyrate . Positive_regulation MMP28 HMGB1 21871094 2510324 in complex with IL-1ß *increased* [MMP] production from both RASF and OASF . Positive_regulation MMP28 HOOK1 23166329 2723321 Treatment with specific inhibitors for AP-1 or NF-?B strongly blocked the [MMP] *up-regulation* by . Positive_regulation MMP28 HPR 13679861 1140723 Moreover , although reactive oxygen species ( ROS ) overproduction appears to be instrumental for <4-HPR> *induced* [MMP] and apoptosis , inhibition of the NF-kappaB or p53 mediated signal transduction pathways failed to modulate 4-HPR induced apoptosis . Positive_regulation MMP28 HPR 13679861 1140745 Cells with a Bax ( -/- ) Bak ( -/- ) genotype were resistant against the <4-HPR> *induced* [MMP] , overproduction of ROS and cell death . Positive_regulation MMP28 HRAS 10811109 692859 Similarly , a farnesyltransferase inhibitor , manumycin A , and a MEK1 inhibitor , U0126 , *suppressed* [MMP] secretion in a dose dependent manner , whereas a PI3 kinase inhibitor , wortmannin , could not . Positive_regulation MMP28 HRAS 19360310 2058262 Taken together , this study clearly demonstrated the inhibitory effect of simvastatin and lovastatin on *induced* invasion , [MMP] expression and signal transduction in MCF10A breast epithelial cells , providing supporting rationale for future statin trials as a therapeutic intervention to regulate breast cancer metastasis . Positive_regulation MMP28 HSPD1 9711934 527014 Chlamydial and human *induce* TNF-alpha and [MMP] production by macrophages . Positive_regulation MMP28 HSPG2 23644655 2926243 We demonstrated that macrophages stimulate cancer cell invasion , motility and migration , and that these effects depend on [matrix metalloproteinase (MMP)] activity and on the *activation* of epidermal growth factor receptor (EGFR) ( at the residue Y ( 1086 ) ) , ( phospholipase C-gamma ) and Gab1 ( GRB2 associated binding protein-1 ) , as evidenced by siRNA ( small interference RNA ) experiments . Positive_regulation MMP28 HSPG2 8705837 343756 also *induced* [MMP] expression in the cultured epithelial cells . Positive_regulation MMP28 HSPG2 8705837 343800 Bacterial may induce degranulation of PMN MMPs and *increase* [MMP] expression in oral epithelial cells . Positive_regulation MMP28 HSPG2 9393778 467877 Gelatin and casein zymography of cell culture medium indicated that the broad-spectrum of Bacillus cereus *induced* [matrix metalloproteinase (MMP)] production in epithelial cells of human skin ( NHEK ) , human gingiva ( HGE ) , and porcine periodontal ligament ( PLE ) . Positive_regulation MMP28 HTRA1 22556410 2614125 Recombinant *induced* [MMP] production in IVD cell cultures through a mechanism critically dependent on MEK but independent of IL-1ß signaling . Positive_regulation MMP28 IFNG 7861007 295298 These data suggest that *enhances* [MMP] gene expression at the post-transcriptional level . Positive_regulation MMP28 IFNG 7872603 296608 IL-2 , IL-6 , and *had* no consistent effect on [MMP] production . Positive_regulation MMP28 IGFBP1 15590975 1346147 Cell numbers were increased only by 100 nM IGFBP-1 isoforms ( P < 0.05 ) , whereas [MMP] levels released from term cells were optimally *increased* by 1-10 nM . Positive_regulation MMP28 IL10 12945803 1136295 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL10 9892093 558611 In all but one cell line no *enhancement* of [MMP] expression by was detected . Positive_regulation MMP28 IL11 12945803 1136296 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL13 12945803 1136297 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL13 21224056 2379414 Differences between pemphigoid and normal conjunctival fibroblasts with respect to collagen contraction and [MMP] secretion in the *presence* of were also observed . Positive_regulation MMP28 IL13 21858811 2599235 Mechanistically , *enhanced* ERK1/2 , AP-1 and [MMP] activities only in IL-13Ra2 positive cells but not in IL-13Ra2 negative cells . Positive_regulation MMP28 IL15 12945803 1136298 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL15 21247265 2419658 *induced* MC-derived [MMP] production . Positive_regulation MMP28 IL16 12945803 1136299 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL17A 14709335 1196633 ERK pathway inhibitors , PD98059 and U0126 , down-regulated *induced* [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP28 IL17A 15751058 1379906 Moreover , local gene transfer *increased* [MMP] expression without the need for IL-1 , although IL-1 remained essential for part of the cartilage VDIPEN expression . Positive_regulation MMP28 IL17A 19527710 2157334 induces myocardial fibrosis and *enhances* RANKL/OPG and [MMP/TIMP] signaling in isoproterenol induced heart failure . Positive_regulation MMP28 IL18 12945803 1136300 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL19 12945803 1136301 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL1A 10356417 618230 NO also may be involved as a mediator of *induced* expression of [MMP] , mRNA , and protein and may contribute as an activator of the latent forms of the enzymes . Positive_regulation MMP28 IL1A 10553093 565548 In vitro studies showed that SLN-1 is also pivotally involved in *induced* [MMP] activity . Positive_regulation MMP28 IL1A 11327259 807559 A decrease in , IL-1beta , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP28 IL1A 15090411 1237902 and LPS *had* no effect on [MMP/TIMP] production by cultured corneal epithelial cells and keratocytes . Positive_regulation MMP28 IL1A 15201935 1260845 and TNF-alpha are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP28 IL1A 18050309 1874424 We used an in vitro model system to examine the hypotheses that acute exposure to IL-1 inhibits meniscal repair , and that an *mediated* increase in [matrix metalloproteinase (MMP)] activity is associated with the inhibition of repair . Positive_regulation MMP28 IL1A 20202487 2259350 *increased* [MMP] activity , S-GAG release , and NO production , while decreasing the shear strength and tissue repair in the interface . Positive_regulation MMP28 IL1A 20472558 2283315 We examined adhesion restricted signaling pathways that enable *induced* [MMP] release in human gingival and murine fibroblasts . Positive_regulation MMP28 IL1A 20799933 2324433 In OA synoviocytes , HMGB1 alone at concentrations of 15 or 25 ng/ml did not affect the production of IL-6 , IL-8 , CCL2 , CCL20 , MMP-1 or MMP-3 , but in the *presence* of , a significant potentiation of protein and mRNA expression , as well as [MMP] activity was observed . Positive_regulation MMP28 IL1A 21035559 2370154 We have previously reported that up-regulates the expression of Wnt-5A and the activation of Wnt-5A signaling *induces* [matrix metalloproteinase (MMP)] through the c-Jun N-terminal kinase pathway in condylar chondrocytes (CCs) of the temporomandibular joint ( TMJ ) . Positive_regulation MMP28 IL1A 22328140 2629900 The aim of this study was to investigate the role of Wnt/ß-catenin signaling in *induced* [MMP] expression in human chondrocytes . Positive_regulation MMP28 IL1A 22328140 2630217 Wnt/ß-catenin signaling in human chondrocytes had an unexpected anticatabolic role by counteracting NF-?B mediated [MMP] expression *induced* by in a negative feedback loop . Positive_regulation MMP28 IL1A 22415590 2686490 Stimulation of cells with only *resulted* in an overexpression of [MMP] and their TIMP mRNAs . Positive_regulation MMP28 IL1A 22415590 2686514 Proinflammatory cytokine *upregulates* [MMP] and TIMP mRNAs expression in colon cancer epithelial cells Caco-2 . Positive_regulation MMP28 IL1A 22577074 2619322 *induced* [MMP] expression and activation as well as collagen degradation were also blocked by the p38 MAPK inhibitor SB203580 . Positive_regulation MMP28 IL1A 23013178 2679330 rEq *increased* PGE ( 2 ) concentration , sGAG release from explants , chondrocyte apoptosis , and [MMP] gene expression . Positive_regulation MMP28 IL1A 24286132 2877258 Both FN-fs and *increased* NO , PGE2 and [MMP] production ( all P < 0.001 ) . Positive_regulation MMP28 IL1A 9538225 497704 sequentially *stimulated* mRNA expression of iNOS , membrane type [1-MMP] , MMP-9 and -3 , and bFGF , in that order . Positive_regulation MMP28 IL1A 9858899 555697 The CAPL protein expressed in cell-cultures appear to block the [MMP] *induction* by bFGF and . Positive_regulation MMP28 IL1B 10727770 678095 and TPA alone *induced* [MMP] activity in HIG-82 cells . Positive_regulation MMP28 IL1B 10864917 705825 and TNF-alpha each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP28 IL1B 10895370 711578 In support of this result , stimulation *induced* the expression of membrane type matrix-metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation MMP28 IL1B 11327259 807560 A decrease in IL-1alpha , , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP28 IL1B 11467889 840791 In all cases , PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on *induction* of [MMP] expression . Positive_regulation MMP28 IL1B 11997239 939290 produced a dose dependent *increase* in [MMP] activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min . Positive_regulation MMP28 IL1B 14872494 1208444 Preincubation with anti-CD44 antibody , which suppressed IL-1beta stimulated MMPs , reversed the inhibitory effect of HA on [MMP] production that was *induced* by in normal and OA cartilage . Positive_regulation MMP28 IL1B 16449361 1573869 HA at > or =2 mg/ml significantly inhibited [MMP] production *induced* by in a dose dependent manner . Positive_regulation MMP28 IL1B 16449361 1573891 Inhibition studies revealed the requirement of NF-kappaB , p38 and c-jun NH2-terminal kinase ( JNK ) for *induced* [MMP] production . Positive_regulation MMP28 IL1B 17328062 1711892 SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on *stimulated* [MMP] production and collagen degradation . Positive_regulation MMP28 IL1B 17925024 1835219 These findings demonstrate , for the first time , that glucosamine inhibits *stimulated* [MMP] production in human chondrocytes by affecting MAPK phosphorylation . Positive_regulation MMP28 IL1B 18403593 1899524 DHA significantly decreased VSMC migration/proliferation *induced* by as well as [fibrinolytic/MMP] activity . Positive_regulation MMP28 IL1B 18535174 1928791 *stimulated* [MMP] mRNA synthesis in wild-type , but not in IL-1RI-null cardiac fibroblasts . Positive_regulation MMP28 IL1B 19056796 2017708 Cordycepin is a potent inhibitor of *induced* chemokine production and [MMP] expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs . Positive_regulation MMP28 IL1B 19542681 2099191 *induced* [MMP] production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ) , p38 kinase , and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase (MAPK) family signal transduction molecules . Positive_regulation MMP28 IL1B 20403707 2282279 *induced* [MMP] production was significantly augmented in the presence of sIL-6R . Positive_regulation MMP28 IL1B 21344389 2480435 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Positive_regulation MMP28 IL1B 22792188 2628265 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation MMP28 IL1B 9558121 500078 Recombinant TNF-alpha and added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP28 IL1B 9821179 548090 The inflammatory cytokine did not *induce* [MMP] or TIMP expression . Positive_regulation MMP28 IL1B 9890433 585410 A beta , but not or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells , as well as *increased* the expression of the well-known activator of MMP-2 , membrane-type ( MT ) [-MMP] . Positive_regulation MMP28 IL1B 9933437 589382 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by and TNF-alpha or down-regulated by IFN-gamma . Positive_regulation MMP28 IL2 12945803 1136302 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL20 12945803 1136303 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL21 12945803 1136304 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL21 16682426 1645791 *enhances* [MMP] secretion without affecting gene transcription and protein synthesis . Positive_regulation MMP28 IL21 17442980 1729737 In this study , we have examined the role of the T cell cytokine IL-21 in Hp-infected gastric mucosa and evaluated whether *regulates* [MMP] production by gastric epithelial cells . Positive_regulation MMP28 IL22 12945803 1136287 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL24 12945803 1136285 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL25 12945803 1136286 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL26 12945803 1136291 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL27 12945803 1136292 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL3 12945803 1136305 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL31 12945803 1136293 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL32 12945803 1136290 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL33 12945803 1136289 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL34 12945803 1136294 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL37 12945803 1136288 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL4 12945803 1136306 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL5 12945803 1136307 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL6 11327259 807561 A decrease in IL-1alpha , IL-1beta , and would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP28 IL6 12945803 1136308 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL6 15996070 1430144 markedly *induced* activation of STAT and extracellular signal related kinase ( ERK1/2 ) and the subsequent expression of the collagenases MMP-1 and MMP-13 as well as MMP-3 , an aggrecan degrading enzyme and activator of [pro-MMP] . Positive_regulation MMP28 IL6 16023653 1525141 The linkage between CEE alone or with a progestin and increased cardiovascular events may be associated with a rise in CRP level , but not through the mechanisms of *mediated* inflammation , endothelial dysfunction or increased [MMP] activity . Positive_regulation MMP28 IL6 19628948 2142960 In the present study , we investigated the participation of inflammatory cytokine induced mediated matrix metalloproteinase (MMP) expressions and inhibition of *induced* [MMP] secretion in amniotic epithelial cells by tocilizumab . Positive_regulation MMP28 IL6 19628948 2142982 At a low concentration of 1 microg/ml , tocilizumab ( anti-human IL-6 receptor monoclonal antibody ) inhibited the *induced* [MMP] secretion . Positive_regulation MMP28 IL6 20225236 2243848 Although it is known that interleukin (IL)-6 is a key proinflamatory cytokine , it remains unclear how *regulates* [MMP] expression by mononuclear phagocytes . Positive_regulation MMP28 IL6 21059338 2354647 High molecular weight hyaluronic acid inhibits *induced* [MMP] production from human chondrocytes by up-regulating the ERK inhibitor , MKP-1 . Positive_regulation MMP28 IL7 12945803 1136309 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL8 12945803 1136310 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IL9 12945803 1136311 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP28 IQGAP1 18541705 1923557 We further show that the exocyst and are *required* for the accumulation of cell surface membrane type 1 [MMP] at invadopodia . Positive_regulation MMP28 IRF3 20483755 2270062 also partially *regulates* expression of other cytokines and [MMP] through activation of c-Jun and the AP-1 promoter site . Positive_regulation MMP28 IRS1 20525764 2301492 *regulates* the cellular differentiation and the [matrix metallopeptidase] expression of preosteoblastic cells . Positive_regulation MMP28 ITGA2 14973117 1212347 Additionally , activation of the ET ( B ) R pathway increases alpha ( v ) beta ( 3 ) and expression and matrix metalloproteinase (MMP)-2 and MMP-9 , membrane [type-1-MMP] *activation* , and tissue inhibitor MMP-2 secretion . Positive_regulation MMP28 ITGA4 12594231 1060781 may be partially *involved* in the [MMP] induction by COOH-HBFN-f . Positive_regulation MMP28 ITGA5 18243246 1871477 Blocking of with anti-alpha5 monoclonal antibody *inhibits* the fibronectin induced [MMP] activation response appreciably . Positive_regulation MMP28 ITGB1 14973117 1212348 Additionally , activation of the ET ( B ) R pathway increases alpha ( v ) beta ( 3 ) and expression and matrix metalloproteinase (MMP)-2 and MMP-9 , membrane [type-1-MMP] *activation* , and tissue inhibitor MMP-2 secretion . Positive_regulation MMP28 ITGB1 18243246 1871478 Blocking of with anti-alpha5 monoclonal antibody *inhibits* the fibronectin induced [MMP] activation response appreciably . Positive_regulation MMP28 ITIH4 22092673 2514199 Antioxidant gene delivery blunted *induced* [MMP] production . Positive_regulation MMP28 JUN 11861377 917144 These results suggest that nobiletin inhibits tumor cell invasive activity not only by suppressing the expression of MMPs but also augmenting TIMP-1 production in tumor cells , and that the nobiletin mediated inhibition of binding activity is at least partly *involved* in the suppression of [MMP] expression . Positive_regulation MMP28 JUN 17348021 1748191 Here we provide genetic and biochemical evidence that EGF-R- and mediated signals are *required* for [MMP] expression and collagen contraction in fibroblasts . Positive_regulation MMP28 JUN 17696279 1788599 We evaluated whether a vanadium inhibitor could *reduce* [MMP] expression and subsequent joint damage in CIA . Positive_regulation MMP28 JUN 21600739 2449897 The results indicate that GlcNAc *inhibited* UVB induced collagenolytic [MMP] production by interfering with Ca ( 2+ ) -dependent Akt and and NF-?B signaling . Positive_regulation MMP28 JUN 23466236 2766047 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of mitogen activated protein kinase (MAPK) , ATF-2 , and , and [MMP] expression . Positive_regulation MMP28 KDR 18093986 1889693 Inhibition of and VEGF [ by soluble FMS-like tyrosine kinase-1 ( sFlt1 ) ] *down-regulated* visfatin induced [MMP] induction . Positive_regulation MMP28 KRAS 10811109 692860 Similarly , a farnesyltransferase inhibitor , manumycin A , and a MEK1 inhibitor , U0126 , *suppressed* [MMP] secretion in a dose dependent manner , whereas a PI3 kinase inhibitor , wortmannin , could not . Positive_regulation MMP28 LCN2 16446702 1521691 The increased expression of , which *activates* [matrix metalloproteinases (MMP)] , is consistent with our previous findings that MMP-9 and other MMPs are highly expressed in pterygium basal epithelium . Positive_regulation MMP28 LEO1 23911909 2840318 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Positive_regulation MMP28 LEP 14629027 1170356 *had* no effect on cytokine and [MMP] production by these cells . Positive_regulation MMP28 LEP 21385940 2416163 *increased* expression and cell surface localization of membrane type 1 [(MT1)-MMP] , measured by cell surface biotinylation assay and antibody based colorimetric detection of an exofacial epitope in intact cells . Positive_regulation MMP28 LGALS1 19276182 2051327 We conclude that is *involved* in tumor invasion and metastasis by increasing [MMP] expression and reorganizing cytoskeletons in oral cancers and lung adenocarcinoma . Positive_regulation MMP28 LOX 20654727 2340555 The inhibitors of COX and/or could *inhibit* cell proliferation , [MMP] activity and invasion in head and neck and colon cancer cells . Positive_regulation MMP28 LPA 16687414 1584161 Overexpression of dominant negative PKCdelta or pretreatment with a PKCdelta inhibitor ( rottlerin ) or Src kinase family inhibitor ( PP2 ) partially blocked *induced* [MMP] activation , proHB-EGF shedding , and EGFR tyrosine phosphorylation . Positive_regulation MMP28 LPA 16687414 1584184 Down-regulation of Lyn kinase , but not Src kinase , by specific small interfering RNA mitigated *induced* [MMP] activation , proHB-EGF shedding , and EGFR phosphorylation . Positive_regulation MMP28 LPA 22348348 2606169 Ki16198 inhibited LPA induced migration and invasion in several pancreatic cancer cells in vitro , which was associated with the inhibition of *induced* [MMP] production . Positive_regulation MMP28 MAP2K1 10811109 692861 Similarly , a Ras farnesyltransferase inhibitor , manumycin A , and a inhibitor , U0126 , *suppressed* [MMP] secretion in a dose dependent manner , whereas a PI3 kinase inhibitor , wortmannin , could not . Positive_regulation MMP28 MAP2K1 15252145 1271552 Therefore , these results introduce novel evidence that the antitumor effects of nobiletin are finely regulated by the following intracellular mechanisms : ( 1 ) the inhibition of activity is *involved* in the suppression of [MMP] expression and ( 2 ) the activation of the novel PKCbetaII/epsilon-JNK pathway is associated with the augmentation of TIMP-1 expression . Positive_regulation MMP28 MAP2K1 19833163 2196085 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP28 MAP2K1 20545600 2308372 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP28 MAP2K1 22310287 2718913 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP28 MAP2K2 19833163 2196086 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP28 MAP2K2 20545600 2308373 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP28 MAP2K2 22310287 2718914 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP28 MAP2K3 19833163 2196087 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP28 MAP2K3 20545600 2308374 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP28 MAP2K3 22310287 2718915 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP28 MAP2K4 19833163 2196088 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP28 MAP2K4 20545600 2308375 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP28 MAP2K4 22310287 2718916 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP28 MAP2K5 19833163 2196089 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP28 MAP2K5 20545600 2308376 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP28 MAP2K5 22310287 2718917 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP28 MAP2K6 19833163 2196090 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP28 MAP2K6 20545600 2308377 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP28 MAP2K6 22310287 2718918 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP28 MAP2K7 19833163 2196091 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP28 MAP2K7 20545600 2308378 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP28 MAP2K7 22310287 2718919 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP28 MAPK1 17108127 1645249 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP28 MAPK1 17925024 1835220 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP28 MAPK1 21082265 2407270 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP28 MAPK1 22749179 2622688 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP28 MAPK1 23466236 2766048 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP28 MAPK1 24023297 2837347 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP28 MAPK10 17108127 1645250 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP28 MAPK10 17925024 1835221 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP28 MAPK10 21082265 2407271 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP28 MAPK10 22749179 2622689 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP28 MAPK10 23466236 2766049 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP28 MAPK10 24023297 2837348 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP28 MAPK11 17108127 1645251 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP28 MAPK11 17925024 1835222 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP28 MAPK11 21082265 2407272 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP28 MAPK11 22749179 2622690 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP28 MAPK11 23466236 2766050 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP28 MAPK11 24023297 2837349 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP28 MAPK12 17108127 1645252 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP28 MAPK12 17925024 1835223 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP28 MAPK12 21082265 2407273 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP28 MAPK12 22749179 2622691 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP28 MAPK12 23466236 2766051 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP28 MAPK12 24023297 2837350 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP28 MAPK13 17108127 1645253 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP28 MAPK13 17925024 1835224 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP28 MAPK13 21082265 2407274 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP28 MAPK13 22749179 2622692 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP28 MAPK13 23466236 2766052 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP28 MAPK13 24023297 2837351 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP28 MAPK14 17108127 1645254 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP28 MAPK14 17925024 1835225 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP28 MAPK14 21082265 2407275 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP28 MAPK14 22749179 2622693 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP28 MAPK14 23466236 2766053 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP28 MAPK14 24023297 2837352 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP28 MAPK15 17108127 1645247 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP28 MAPK15 17925024 1835218 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP28 MAPK15 21082265 2407269 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP28 MAPK15 22749179 2622687 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP28 MAPK15 23466236 2766046 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP28 MAPK15 24023297 2837346 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP28 MAPK3 17108127 1645255 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP28 MAPK3 17925024 1835226 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP28 MAPK3 21082265 2407276 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP28 MAPK3 22749179 2622694 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP28 MAPK3 23466236 2766054 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP28 MAPK3 24023297 2837353 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP28 MAPK4 17108127 1645256 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP28 MAPK4 17925024 1835227 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP28 MAPK4 21082265 2407277 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP28 MAPK4 22749179 2622695 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP28 MAPK4 23466236 2766055 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP28 MAPK4 24023297 2837354 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP28 MAPK6 17108127 1645257 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP28 MAPK6 17925024 1835228 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP28 MAPK6 21082265 2407278 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP28 MAPK6 22749179 2622696 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP28 MAPK6 23466236 2766056 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP28 MAPK6 24023297 2837355 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP28 MAPK7 17108127 1645258 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP28 MAPK7 17925024 1835229 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP28 MAPK7 21082265 2407279 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP28 MAPK7 22749179 2622697 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP28 MAPK7 23466236 2766057 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP28 MAPK7 24023297 2837356 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP28 MAPK8 11920420 926182 Complete inhibition of [MMP] expression and joint destruction will likely *require* combined and JNK-2 inhibition . Positive_regulation MMP28 MAPK8 17108127 1645259 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP28 MAPK8 17925024 1835230 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP28 MAPK8 21082265 2407280 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP28 MAPK8 22749179 2622698 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP28 MAPK8 23466236 2766058 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP28 MAPK8 24023297 2837357 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP28 MAPK9 11920420 926183 Complete inhibition of [MMP] expression and joint destruction will likely *require* combined JNK-1 and inhibition . Positive_regulation MMP28 MAPK9 17108127 1645260 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP28 MAPK9 17925024 1835231 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP28 MAPK9 21082265 2407281 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP28 MAPK9 22749179 2622699 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP28 MAPK9 23466236 2766059 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP28 MAPK9 24023297 2837358 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP28 MIF 16872482 1663458 In the present study , we determined the *role* of in RA synovial fibroblast [MMP] production and the underlying signaling mechanisms . Positive_regulation MMP28 MIF 19950249 2184902 The use of different strategies to block MIF action , including an anti-MIF antibody , the MIF inhibitor ISO-1 and knockout mice for the MIF gene , showed that cytokine secretion and [MMP] expression during infection were *regulated* by , suggesting that this cytokine acts in autocrine and paracrine manner upstream in the macrophage activation cascade . Positive_regulation MMP28 MME 20874839 2343092 In the *presence* of , substance P levels in supernatants as well as [MMP] production and the invasive potency of SCC were significantly augmented compared with control scramble RNA transfected Fb . Positive_regulation MMP28 MMP13 23722213 2801706 Additionally , the addition of specific and MMP14 inhibitors *prevented* the [MMP] activities of supernatants collected from 4T1 cells incubated with D1CM , CCL5 or CCL9 . Positive_regulation MMP28 MMP14 23722213 2801707 Additionally , the addition of specific MMP9/MMP13 and inhibitors *prevented* the [MMP] activities of supernatants collected from 4T1 cells incubated with D1CM , CCL5 or CCL9 . Positive_regulation MMP28 MMP2 10333542 615100 *Activation* of by membrane type-MMP ( [MT-MMP] ) is reported to be a rate limiting step for catalytic function . Positive_regulation MMP28 MMP2 10642509 660827 Both in the insect cells and in vitro , *activation* of by [fMT1-MMP] was enhanced at low concentrations of TIMP-2 and inhibited by its higher concentrations . Positive_regulation MMP28 MMP2 10642509 660892 In contrast , *activation* of by [sMT1-MMP] was dose-dependently inhibited by TIMP-2 . Positive_regulation MMP28 MMP2 11114732 759254 In addition , activation of [MMP-secretion] and tyrosine phosphorylation of FAK by Con A , but not the proteolytic *activation* of , required attachment of the cells to the extracellular matrix . Positive_regulation MMP28 MMP2 11340084 812324 The Rac1 dependent activation occurred in a cell associated fashion and *required* [MMP] activities . Positive_regulation MMP28 MMP2 11382769 835032 In contrast to the stimulatory effect of TIMP-2 on pro-MMP-2 activation by MT1-MMP , *activation* of by [DeltaMT1-MMP] in the presence of claudin-5 and proDeltaMMP-2 processing by MT1-MMP were both inversely repressed by expression of exogenous TIMP-2 . Positive_regulation MMP28 MMP2 15530852 1332728 Both recombinant human TIMP-1 and the synthetic [MMP] *inhibitors* , GM6001 and Inhibitor III , suppressed migration of human dermal microvascular endothelial cells ( HDMVEC ) in a dose dependent fashion . Positive_regulation MMP28 MMP2 17986262 1845888 These results suggest that , during colon morphogenesis , [MMP] activity is under strict spatio-temporal control , and that the activity of , which is regulated at both the transcriptional and proteolytic activation levels , is very much *involved* in rat colon morphogenesis . Positive_regulation MMP28 MMP2 19224446 2039798 *Activation* of by membrane type [1-MMP] and abnormal immunolocalization of the basement membrane components laminin and type IV collagen in canine spontaneous hemangiosarcomas . Positive_regulation MMP28 MMP2 22729485 2644232 Specific inhibitors to MMPs revealed that [MMP] activity was *due* to . Positive_regulation MMP28 MMP2 7822314 293011 The expression of [MT-MMP] *induced* specific activation of 72-kDa ( Sato , H. , Takino , T. , Okada , Y. , Cao , J. , Shinagawa , A. , Yamamoto , E. , and Seiki , M. ( 1994 ) Nature 370 , 61-65 ) . Positive_regulation MMP28 MMP3 18283281 1919293 Mphi conditioned media ( Mphi-CM ) increased the levels of TNF-alpha mRNA expression in 3T3-L1 adipocytes , and these adipocyte responses were abolished by treatment with GM6001 , a broad-spectrum [MMP] *inhibitor* , or NNGH ( N-isobutyl-N- ( 4-methoxyphenylsulfonyl ) -glycylhydroxamic acid ) , an inhibitor . Positive_regulation MMP28 MMP9 11971672 933649 Zymography demonstrated a dose dependent *increase* in 92-kDa [MMP] ( pro-MMP-9 ) activity ( P < 0.001 ) with corresponding increases in protein ( P = 0.03 ) and mRNA levels ( P = 0.004 ) . Positive_regulation MMP28 MMP9 15530852 1332729 Both recombinant human TIMP-1 and the synthetic [MMP] *inhibitors* , GM6001 and Inhibitor III , suppressed migration of human dermal microvascular endothelial cells ( HDMVEC ) in a dose dependent fashion . Positive_regulation MMP28 MMP9 23722213 2801708 Additionally , the addition of specific and MMP14 inhibitors *prevented* the [MMP] activities of supernatants collected from 4T1 cells incubated with D1CM , CCL5 or CCL9 . Positive_regulation MMP28 MOAP1 22749179 2622686 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP28 MPZ 19851865 2203219 The loss of [MMP] *induced* by was preventive by DbetaHB . Positive_regulation MMP28 MSH2 16511523 1574260 Further , significantly *increased* [matrix metalloproteinase (MMP)] , while tissue inhibitors of matrix metalloproteinase ( TIMPs ) were inactivated . Positive_regulation MMP28 MSH3 16511523 1574261 Further , significantly *increased* [matrix metalloproteinase (MMP)] , while tissue inhibitors of matrix metalloproteinase ( TIMPs ) were inactivated . Positive_regulation MMP28 MSH4 16511523 1574262 Further , significantly *increased* [matrix metalloproteinase (MMP)] , while tissue inhibitors of matrix metalloproteinase ( TIMPs ) were inactivated . Positive_regulation MMP28 MSH5 16511523 1574263 Further , significantly *increased* [matrix metalloproteinase (MMP)] , while tissue inhibitors of matrix metalloproteinase ( TIMPs ) were inactivated . Positive_regulation MMP28 MSH6 16511523 1574264 Further , significantly *increased* [matrix metalloproteinase (MMP)] , while tissue inhibitors of matrix metalloproteinase ( TIMPs ) were inactivated . Positive_regulation MMP28 MSLN 22371455 2587025 expression *promotes* MPM cell invasion and [MMP] secretion in both human and murine MPM cells . Positive_regulation MMP28 MST1 907425 6425 [MMP-and] *induced* cells catalyze the oxidation of a variety of substituted phenols . Positive_regulation MMP28 MTA1 21356366 2394660 *induced* [matrix metalloproteinase (MMP)] and interleukin-8 transcription in HCC cells in vitro , accompanied by enhanced proliferation and activation of the transcription factor NF?B . Positive_regulation MMP28 MTA2 21356366 2394661 *induced* [matrix metalloproteinase (MMP)] and interleukin-8 transcription in HCC cells in vitro , accompanied by enhanced proliferation and activation of the transcription factor NF?B . Positive_regulation MMP28 MTA3 21356366 2394659 *induced* [matrix metalloproteinase (MMP)] and interleukin-8 transcription in HCC cells in vitro , accompanied by enhanced proliferation and activation of the transcription factor NF?B . Positive_regulation MMP28 MTOR 18375114 1898989 Furthermore , inhibitor rapamycin not only drastically *inhibited* migration and [MMP] production , but also induced type II programmed cell death , autophagic cell death . Positive_regulation MMP28 MYL2 19961849 2204123 Further , drug *induced* effects on actin cytoskeletal organization , cell adhesions , phosphorylation , [matrix metalloproteinase (MMP)] activity , and cytoskeletal protein profile in porcine trabecular meshwork ( TM ) cells were determined by immunofluorescence , zymography , and mass spectrometry . Positive_regulation MMP28 MYLIP 23333633 2747186 *increased* the [MMP] inhibitor RECK protein in MDA-MB-231 cells while pre-miR-182 reduced RECK protein but not mRNA in normal mammary epithelial H184B5F5/M10 cells . Positive_regulation MMP28 MYLIP 24447911 2923078 These results indicate that Ang II-induced CF migration is differentially regulated by mediated [MMP] *induction* and RECK suppression , and that DHA has the potential to upregulate RECK , and therefore may exert potential beneficial effects in cardiac fibrosis . Positive_regulation MMP28 MYLIP 24812324 2944907 Mechanistically , *stimulated* [MMP] activity in the aortic wall by directly targeting 2 MMP inhibitors : tissue inhibitor of metalloproteinase 3 ( TIMP3 ) and reversion inducing cysteine-rich protein with kazal motifs ( RECK ) . Positive_regulation MMP28 NA 20043100 2192839 GSH and , an anti-oxidant agent , *blocked* the curcumin induced ROS production , [MMP] loss and rescued cells from curcumin induced apoptosis . Positive_regulation MMP28 NA 23352441 2747565 Phagocytosis , the loss of [MMP] , autophagy and the activated signaling pathways were all *suppressed* by ROS scavenger , H2O2 scavenger catalase or OH scavenger glutathione ( GSH ) . Positive_regulation MMP28 NAMPT 18093986 1889692 Inhibition of VEGFR2 and VEGF [ by soluble FMS-like tyrosine kinase-1 ( sFlt1 ) ] down-regulated *induced* [MMP] induction . Positive_regulation MMP28 NAMPT 18093986 1889750 Inhibition of PI3K/Akt and ERK ( 1/2 ) pathways led to significant decrease of *induced* [MMP] and VEGF production and activation , along with significant reduction in endothelial proliferation and capillary tube formation . Positive_regulation MMP28 NAMPT 18093986 1889773 Our data provide the first evidence of *induced* endothelial VEGF and [MMP] production and activity . Positive_regulation MMP28 NFKB1 16423269 1515321 A specific inhibitor of *reduced* [MMP] production by alveolar macrophages from SP-D-/- mice . Positive_regulation MMP28 NFKB1 19320561 2162334 Hence , induction of by shear stress *contributes* to [MMP] induction and allows long-term flow induced vascular enlargement . Positive_regulation MMP28 NFKB1 19639210 2113187 These data suggest that VK2 *inhibits* [MMP] expression by suppressing and MAP kinase activity and might be potentially useful in the treatment of HCC . Positive_regulation MMP28 NOX1 22120495 2535114 After 3h exposure to a reducing extracellular redox state ( E ( h ) CySS=-180mV ) , [matrix metalloprotease (MMP)] , gelatinase , and activities *increased* , correlating with increases in cell invasion , cell migration , and extracellular hydrogen peroxide levels in PC3 cells but not PrECs . Positive_regulation MMP28 NOX3 22120495 2535115 After 3h exposure to a reducing extracellular redox state ( E ( h ) CySS=-180mV ) , [matrix metalloprotease (MMP)] , gelatinase , and activities *increased* , correlating with increases in cell invasion , cell migration , and extracellular hydrogen peroxide levels in PC3 cells but not PrECs . Positive_regulation MMP28 NOX4 22120495 2535116 After 3h exposure to a reducing extracellular redox state ( E ( h ) CySS=-180mV ) , [matrix metalloprotease (MMP)] , gelatinase , and activities *increased* , correlating with increases in cell invasion , cell migration , and extracellular hydrogen peroxide levels in PC3 cells but not PrECs . Positive_regulation MMP28 NOX5 22120495 2535113 After 3h exposure to a reducing extracellular redox state ( E ( h ) CySS=-180mV ) , [matrix metalloprotease (MMP)] , gelatinase , and activities *increased* , correlating with increases in cell invasion , cell migration , and extracellular hydrogen peroxide levels in PC3 cells but not PrECs . Positive_regulation MMP28 NPR1 15710627 1402744 Our results show that reduced signaling *activates* [MMP] , transforming growth factor-beta1 , and TNF-alpha expression in Npr1-/- mouse hearts . Positive_regulation MMP28 NPS 9766654 538540 These data indicate that can *regulate* [MMP] activity , which , in turn , could facilitate prostate cancer progression . Positive_regulation MMP28 NR4A1 24851101 2940536 Simvastatin induced expression in RAW 264.7 macrophages and ectopic expression of a dominant negative mutant form of NR4A1 effectively *suppressed* both DNA fragmentation and the disruption of mitochondrial [membrane potential (MMP)] during LPS- and simvastatin induced apoptosis . Positive_regulation MMP28 NRAS 10811109 692862 Similarly , a farnesyltransferase inhibitor , manumycin A , and a MEK1 inhibitor , U0126 , *suppressed* [MMP] secretion in a dose dependent manner , whereas a PI3 kinase inhibitor , wortmannin , could not . Positive_regulation MMP28 OSM 11207308 786940 We have previously shown that *induces* [MMP] and tissue inhibitor of metalloproteinase-3 ( TIMP-3 ) gene expression in chondrocytes by protein tyrosine kinase dependent mechanisms . Positive_regulation MMP28 OSM 11207308 786985 In the present study , we investigated signaling pathways regulating the *induction* of [MMP] and TIMP-3 genes by . Positive_regulation MMP28 OSM 11207308 787029 Thus , *induces* [MMP] and TIMP-3 genes in chondrocytes by activating JAK/STAT and mitogen activated protein kinase signaling cascades , and interference with these pathways may be a useful approach to block the catabolic actions of OSM . Positive_regulation MMP28 OSM 14673992 1178621 The in vivo data clearly indicated that + TNFalpha overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP28 OSM 16549372 1582235 TNF-alpha and induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP28 OSM 17469134 1737511 and TNF *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP28 OTUD7A 23792447 2937850 Further , could *regulate* [MMP] ( matrix metalloproteinase)2 , MMP9 and ICAM1 ( intercellular adhesion molecule ) levels through modulation of the NF-?B ( nuclear factor kappa-light-chain-enhancer of activated B cell ) signaling cascade . Positive_regulation MMP28 PAF1 23911909 2840316 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Positive_regulation MMP28 PAK1 23744893 2807151 Together , these data illustrate the complex interaction between the substratum and PRL/PAK1 signaling in human breast cancer cells and suggest a pivotal *role* for PRL dependent tyrosyl phosphorylation in [MMP] secretion . Positive_regulation MMP28 PAK2 20111678 2178678 In the present study , we examined the effects of resveratrol on apoptotic biochemical events in Hep G2 cells induced by CTN. Resveratrol inhibited CTN induced ROS generation , activation of JNK , loss of mitochondrial [membrane potential (MMP)] , as well as *activation* of caspase-9 , caspase-3 and . Positive_regulation MMP28 PDGFB 18489818 1939168 So , may *induce* the expression of [MMP] for the degradation of collagen type III on the wall of the saccular aneurysms . Positive_regulation MMP28 PDLIM7 12756268 1090676 *triggers* mitochondrial [membrane permeabilization (MMP)] , as detected by the release of cytochrome c . Positive_regulation MMP28 PDLIM7 17913445 1812866 To investigate the *role* of in [MMP] expression in NPC , we cloned the LMP1 gene from NPC samples and transiently expressed it in MRC5 cells ( human lung fibroblasts ) . Positive_regulation MMP28 PEBP4 24276246 2955792 Further investigation showed that *promoted* the expression or activity of the metastasis related proteinases [MMP] ( matrix metalloproteinase) 2 , MMP9 and MMP13 . Positive_regulation MMP28 PGF 11870075 918344 [MMP] activity was localized ( in situ zymography ) to the pericellular area of various cell types in the 0-h group and was markedly *increased* by 30 min ( 2 alpha ) . Positive_regulation MMP28 PI3 20230795 2237643 This involves activation of integrins and focal adhesion formation via inside-out dependent signaling , but does not *require* [MMP] activation . Positive_regulation MMP28 PIK3CA 16142341 1451222 Inhibition of signaling in LM8 by a PI3K inhibitor , LY294002 , or by a dominant negative form of Akt , *resulted* in suppression of [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Positive_regulation MMP28 PIK3R1 16142341 1451223 Inhibition of signaling in LM8 by a PI3K inhibitor , LY294002 , or by a dominant negative form of Akt , *resulted* in suppression of [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Positive_regulation MMP28 PLA2G4A 17981679 1845534 [MMP] production in human fibrosarcoma cells and their invasiveness are *regulated* by group IB secretory phospholipase A2 receptor mediated activation of . Positive_regulation MMP28 PLA2R1 17981679 1845535 [MMP] production in human fibrosarcoma cells and their invasiveness are *regulated* by group IB mediated activation of cytosolic phospholipase A2 . Positive_regulation MMP28 PLG 11204721 785540 The [MMP] are *regulated* at the levels of transcription , zymogen activation by or membrane-type- ( MT ) MMP , and control of enzyme activity by tissue inhibitors of metalloproteinases ( TIMP ) . Positive_regulation MMP28 PLG 11387497 821852 Plasminogen activators (PAs) may also play a role in ECM degradation by the generation of or by [MMP] *activation* . Positive_regulation MMP28 PLG 21311679 2360072 Plasminogen activator inhibitor (PAI)-1 is known to play an important role in renal ECM accumulation in part through suppression of generation and [matrix metalloproteinase (MMP)] *activation* . Positive_regulation MMP28 PLG 21465481 2523797 During wound healing , elevated levels of PAI-1 inhibit uPA/tPA/plasmin and *dependent* [MMP] activities , and , thus , help expedite wound healing . Positive_regulation MMP28 PLG 22798012 2645665 This effect resulted from the presence of the potent [MMP] *inhibitors* , tissue inhibitor of metalloproteinases-1 ( TIMP-1 ) , type-1 activator inhibitor ( PAI-1 ) and thrombospondin-1 (TSP-1) in the amnion dressings , as shown by real-time fluorescence zymography and protein microarrays . Positive_regulation MMP28 PODXL 17616675 1769314 These findings suggest that leads to increased in vitro migration and invasion , *increased* [MMP] expression , and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MMP28 POLDIP2 20230795 2237642 This involves activation of integrins and focal adhesion formation via inside-out dependent signaling , but does not *require* [MMP] activation . Positive_regulation MMP28 POLDIP2 20377132 2239194 In contrast , inhibitor *reduced* cell growth inhibition , apoptosis , and [MMP] ( deltapsi ( m ) ) loss by MG132 . Positive_regulation MMP28 PRG2 10220591 609273 The degradation of was *inhibited* by and [MMP] inhibitor , indicating that MMPs are involved in the degradation of proteoglycans induced by high frequency CTF . Positive_regulation MMP28 PRG3 10220591 609274 The degradation of was *inhibited* by and [MMP] inhibitor , indicating that MMPs are involved in the degradation of proteoglycans induced by high frequency CTF . Positive_regulation MMP28 PRG4 10220591 609275 The degradation of was *inhibited* by and [MMP] inhibitor , indicating that MMPs are involved in the degradation of proteoglycans induced by high frequency CTF . Positive_regulation MMP28 PRKAA1 24255018 2904151 Adiponectin mediated signaling *induces* cell migration , [MMP] activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation MMP28 PRKAA2 24255018 2904152 Adiponectin mediated signaling *induces* cell migration , [MMP] activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation MMP28 PRKAB1 24255018 2904153 Adiponectin mediated signaling *induces* cell migration , [MMP] activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation MMP28 PRKAB2 24255018 2904154 Adiponectin mediated signaling *induces* cell migration , [MMP] activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation MMP28 PRKAG1 24255018 2904155 Adiponectin mediated signaling *induces* cell migration , [MMP] activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation MMP28 PRKAG2 24255018 2904156 Adiponectin mediated signaling *induces* cell migration , [MMP] activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation MMP28 PRSS2 22909050 2678097 *activated* [proMT1-MMP] , as well as altered the expression of TJ protein claudin-7 . Positive_regulation MMP28 PTGER4 8679543 365803 *Stimulation* of [MMP] activities in RNK-16 cells by the thus facilitates migration of the NK cells across vascular basement membranes . Positive_regulation MMP28 PTGS2 17934334 1813409 Selective COX-2 inhibitors , NS-398 and celecoxib , inhibited cell proliferation and abrogated the enhanced mobility , invasiveness and [MMP] activities *induced* by overexpression . Positive_regulation MMP28 PTH 14570746 1155574 Although parathyroid tissue induces angiogenesis when autotransplanted and *regulates* both VEGF and [MMP] expression , there are few studies of angiogenesis and angiogenic factors in parathyroid tumors . Positive_regulation MMP28 RAC1 11340084 812325 The dependent MMP-2 activation occurred in a cell associated fashion and *required* [MMP] activities . Positive_regulation MMP28 RAG2 22213029 2585971 also *prevented* the loss of mitochondrial [membrane potential (MMP)] , alterations in levels of two key mitochondrial Bcl-2 family proteins , and the accumulation of numerous cells into the sub-G ( 1 ) phase that were observed in serum starved osteoblasts . Positive_regulation MMP28 RBBP4 12810630 1102743 In this study , we test the possibility that inhibitor may increase RECK expression to *inhibit* [MMP] activation and cancer cell invasion . Positive_regulation MMP28 RBBP4 20144149 2236026 Transient transfection assays have shown that the *induction* of [MMP28] expression by the inhibitior TSA ( trichostatin A ) is mediated via Sp1 at the GT-box . Positive_regulation MMP28 RBBP7 12810630 1102744 In this study , we test the possibility that inhibitor may increase RECK expression to *inhibit* [MMP] activation and cancer cell invasion . Positive_regulation MMP28 RBBP7 20144149 2236027 Transient transfection assays have shown that the *induction* of [MMP28] expression by the inhibitior TSA ( trichostatin A ) is mediated via Sp1 at the GT-box . Positive_regulation MMP28 RECK 16103099 1444541 , a glycosylphosphatidylinositol (GPI) anchored glycoprotein , negatively *regulates* [matrix metalloproteinases (MMP)] , such as MMP-9 , and inhibits tumor invasion and metastasis . Positive_regulation MMP28 RECK 18989628 2022022 Concluding , our results provide evidences that and TIMP-2 are *involved* in the control of ECM remodeling in distinct phases of osteoblast differentiation by modulating [MMP] activities and a multitude of signaling proteins governs these events . Positive_regulation MMP28 RELA 16423269 1515322 A specific inhibitor of *reduced* [MMP] production by alveolar macrophages from SP-D-/- mice . Positive_regulation MMP28 RELA 19320561 2162335 Hence , induction of by shear stress *contributes* to [MMP] induction and allows long-term flow induced vascular enlargement . Positive_regulation MMP28 RELA 19639210 2113188 These data suggest that VK2 *inhibits* [MMP] expression by suppressing and MAP kinase activity and might be potentially useful in the treatment of HCC . Positive_regulation MMP28 RENBP 21482542 2448350 *enhanced* expression and enzyme activity of [MMP] and ADAMTS genes and resulted in reduction of collagen II . Positive_regulation MMP28 RETN 21277149 2403310 Furthermore , resistin activated PKCe , but selective PKCe inhibitor suppressed *induced* [MMP] expression , activity , and cell migration . Positive_regulation MMP28 RLN1 15642129 1363034 Previously , we showed that dose-dependently *induces* [matrix metalloproteinase (MMP)] expression in isolated joint fibrocartilaginous cells . Positive_regulation MMP28 RLN1 15956693 1422347 In addition , negatively *regulates* expression of endometrial [matrix metalloproteinases (MMP)] , causing decreased endometrial levels of MMP-1 and MMP-3 proteins and increased protein levels of their endogenous inhibitor , tissue inhibitor of metalloproteinase 1 . Positive_regulation MMP28 RLN1 16709614 1584651 Taken together , this study provides proof-of- principle that gene expression targeted to the mouse lungs can *result* in enhanced [MMP] activity offering potential for alleviating disease conditions characterized by dysregulation of extracellular matrix protein accumulation . Positive_regulation MMP28 RLN1 17920032 1843959 Previous studies have indicated that [MMP] production can be *stimulated* by the hormone . Positive_regulation MMP28 RLN2 15642129 1363035 Previously , we showed that dose-dependently *induces* [matrix metalloproteinase (MMP)] expression in isolated joint fibrocartilaginous cells . Positive_regulation MMP28 RLN2 15956693 1422348 In addition , negatively *regulates* expression of endometrial [matrix metalloproteinases (MMP)] , causing decreased endometrial levels of MMP-1 and MMP-3 proteins and increased protein levels of their endogenous inhibitor , tissue inhibitor of metalloproteinase 1 . Positive_regulation MMP28 RLN2 16709614 1584652 Taken together , this study provides proof-of- principle that gene expression targeted to the mouse lungs can *result* in enhanced [MMP] activity offering potential for alleviating disease conditions characterized by dysregulation of extracellular matrix protein accumulation . Positive_regulation MMP28 RLN2 17920032 1843960 Previous studies have indicated that [MMP] production can be *stimulated* by the hormone . Positive_regulation MMP28 RLN3 15642129 1363036 Previously , we showed that dose-dependently *induces* [matrix metalloproteinase (MMP)] expression in isolated joint fibrocartilaginous cells . Positive_regulation MMP28 RLN3 15956693 1422349 In addition , negatively *regulates* expression of endometrial [matrix metalloproteinases (MMP)] , causing decreased endometrial levels of MMP-1 and MMP-3 proteins and increased protein levels of their endogenous inhibitor , tissue inhibitor of metalloproteinase 1 . Positive_regulation MMP28 RLN3 16709614 1584653 Taken together , this study provides proof-of- principle that gene expression targeted to the mouse lungs can *result* in enhanced [MMP] activity offering potential for alleviating disease conditions characterized by dysregulation of extracellular matrix protein accumulation . Positive_regulation MMP28 RLN3 17920032 1843961 Previous studies have indicated that [MMP] production can be *stimulated* by the hormone . Positive_regulation MMP28 RUNX2 21896846 2491771 DEX reduced total A ( 1 ) AR-triggered [MMP] release , and *increased* the active form of MMP-2 release . Positive_regulation MMP28 S100A9 23135911 2722604 *Induction* of cytokines and [matrix metalloproteases (MMP)] by was markedly downregulated in melanoma cells by attenuation of EMMPRIN . Positive_regulation MMP28 SAA1 22076945 2574683 *increased* MMP-1 , MMP-3 , MMP-13 , and [MMP/TIMP] expression in RA FLS and synovial explants ( P < 0.05 ) . Positive_regulation MMP28 SDC1 18378436 1925477 Our results suggest that and beta1 integrin signaling downstream of AG73 *regulate* adhesion and [MMP] production by CAC2 and M1 cells . Positive_regulation MMP28 SDS 17222211 1664170 MMP2 and MMP9 mRNA contents were determined by RT-PCR and [MMP] activity by electrophoresis in gelatin containing polyacrylamide gels in the *presence* of under non reducing conditions . Positive_regulation MMP28 SERPINE1 22798012 2645664 This effect resulted from the presence of the potent [MMP] *inhibitors* , tissue inhibitor of metalloproteinases-1 ( TIMP-1 ) , type-1 plasminogen activator inhibitor ( ) and thrombospondin-1 (TSP-1) in the amnion dressings , as shown by real-time fluorescence zymography and protein microarrays . Positive_regulation MMP28 SKP1 14981939 1182795 did not *enhance* [MMP] activity in any of the cell lines tested . Positive_regulation MMP28 SLC22A3 16940349 1609375 Current results indicate that [epilysin] can *induce* and cell invasion through a TGF-beta dependent mechanism suggesting novel biological roles for this enzyme in the regulation of epithelial cell function and in the induction of carcinogenesis . Positive_regulation MMP28 SOD2 12538496 1050095 The *dependent* increases in AP-1 and SP-1 DNA binding activity , MMP-1 promoter activity , general [MMP] expression , and collagen degradation can be reversed by the hydrogen peroxide detoxifying enzyme , catalase . Positive_regulation MMP28 SPP1 19010864 1991550 , which *activates* [matrix metalloproteinases (MMP)] , is considered a prognostic biomarker in several cancers . Positive_regulation MMP28 SRC 12421825 1036407 This resulted from induced [MMP] *activation* , implicated using PP2 ( Src family kinase inhibitor ) or the expression of a dominant negative Src protein . Positive_regulation MMP28 SRC 21505267 2448650 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the and activating transcription factor 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or [Matrix Metalloproteinase (MMP)] . Positive_regulation MMP28 SSFA2 12594231 1060737 Inhibition studies using protein kinase inhibitors ( PD98059 and SB203580 ) showed that those MAPK pathways contributed to [MMP] *up-regulation* by COOH-HBFN-f and . Positive_regulation MMP28 SSFA2 12594231 1060759 Thus , the present results have clearly shown that COOH-HBFN-f and *stimulate* [MMP] production in association with activation of MAPK pathways in RSF . Positive_regulation MMP28 TAT 22419111 2572691 The anion-channel inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid ( DIDS ) protects isolated mitochondria against *induced* mitochondrial [membrane permeabilization (MMP)] , whereas ruthenium red , a ryanodine receptor blocker , does not . Positive_regulation MMP28 TAT 22419111 2572739 Pharmacologic inhibitors of the permeability transition pore , Bax/Bak inhibitors , and recombinant Bcl-2 and Bcl-XL proteins do not reduce *induced* [MMP] . Positive_regulation MMP28 TBX22 12756268 1090699 Bax-/- Bak-/- double knockout cells fail to undergo [MMP] and cell death in *response* to or NFX induced LMP . Positive_regulation MMP28 TERT 23884427 2861381 Human *regulates* [MMP] expression independently of telomerase activity via NF-?B dependent transcription . Positive_regulation MMP28 TGFB1 10508223 649837 The objective of the present study was to determine whether ( TGF-beta ) *regulates* the expression of [matrix metalloproteinases (MMP)] and the tissue inhibitor of MMP (TIMP) in myometrial smooth muscle cells . Positive_regulation MMP28 TGFB1 10508223 649966 In conclusion , the data indicate that myometrial smooth muscle cells express [MMP] and TIMP mRNA and protein , and their expression is differentially *regulated* by . Positive_regulation MMP28 TGFB1 10633007 576597 In conclusion , these results indicate that mesothelial cells express [MMP] and TIMP mRNA and protein , and their expression is differentially *regulated* by , a mechanism that in part may influence the outcome of peritoneal tissue repair and adhesion formation . Positive_regulation MMP28 TGFB1 11192834 761533 It is known that platelet derived growth factor ( PDGF ) and ( TGF-beta ) are *involved* in the regulation of [MMP] activity and tissue inhibitor of metalloproteinase ( TIMP ) production in non-ocular tissues . Positive_regulation MMP28 TGFB1 15194465 1259951 We demonstrate that *induces* [MMP-activity] in CFBs , thereby facilitating CFBs motility . Positive_regulation MMP28 TGFB1 15247230 1289659 Because transforming growth factor-beta1 ( TGF-beta1 ) promotes tumor invasion in advanced squamous cell carcinomas , the *role* of in the regulation of [MMP] activity in a cellular model of invasive oral squamous cell carcinoma was examined . Positive_regulation MMP28 TGFB1 15780084 1385224 These responses which are dependent on its protease activity appear not to be mediated by PAR-1 activation , the autocrine action of thrombin induced secretion , [MMP] *activation* , or EGF receptor transactivation . Positive_regulation MMP28 TGFB1 18505915 1917871 When cancer cells were cultured on plastic , , TGF-beta2 , and TGF-beta3 *induced* [pro-matrix metalloproteinase (MMP)] secretion , loss of cell-cell junctions , down-regulation of E-cadherin , up-regulation of N-cadherin , and acquisition of a fibroblastoid phenotype , consistent with an epithelial-to-mesenchymal transition . Positive_regulation MMP28 TGFB1 19543300 2103805 Moreover , MS80 arrested *induced* human embryo pulmonary fibroblast ( HEPF ) cell proliferation , collagen deposition and [matrix metalloproteinase (MMP)] activity . Positive_regulation MMP28 TGFB1 20648565 2363114 Our results further suggest that EMMPRIN regulates differentiation through an [MMP] *activation* of ( TGFß ) , a known inhibitor of myoblast 's differentiation , as the increased activation and signaling of TGFß by EMMPRIN was attenuated in the presence of marimastat . Positive_regulation MMP28 TGFB2 10508223 649838 The objective of the present study was to determine whether ( TGF-beta ) *regulates* the expression of [matrix metalloproteinases (MMP)] and the tissue inhibitor of MMP (TIMP) in myometrial smooth muscle cells . Positive_regulation MMP28 TGFB2 11192834 761534 It is known that platelet derived growth factor ( PDGF ) and ( TGF-beta ) are *involved* in the regulation of [MMP] activity and tissue inhibitor of metalloproteinase ( TIMP ) production in non-ocular tissues . Positive_regulation MMP28 TGFB2 18505915 1917872 When cancer cells were cultured on plastic , TGF-beta1 , , and TGF-beta3 *induced* [pro-matrix metalloproteinase (MMP)] secretion , loss of cell-cell junctions , down-regulation of E-cadherin , up-regulation of N-cadherin , and acquisition of a fibroblastoid phenotype , consistent with an epithelial-to-mesenchymal transition . Positive_regulation MMP28 TGFB2 20648565 2363115 Our results further suggest that EMMPRIN regulates differentiation through an [MMP] *activation* of ( TGFß ) , a known inhibitor of myoblast 's differentiation , as the increased activation and signaling of TGFß by EMMPRIN was attenuated in the presence of marimastat . Positive_regulation MMP28 TGFB3 10508223 649839 The objective of the present study was to determine whether ( TGF-beta ) *regulates* the expression of [matrix metalloproteinases (MMP)] and the tissue inhibitor of MMP (TIMP) in myometrial smooth muscle cells . Positive_regulation MMP28 TGFB3 11192834 761535 It is known that platelet derived growth factor ( PDGF ) and ( TGF-beta ) are *involved* in the regulation of [MMP] activity and tissue inhibitor of metalloproteinase ( TIMP ) production in non-ocular tissues . Positive_regulation MMP28 TGFB3 18505915 1917873 When cancer cells were cultured on plastic , TGF-beta1 , TGF-beta2 , and *induced* [pro-matrix metalloproteinase (MMP)] secretion , loss of cell-cell junctions , down-regulation of E-cadherin , up-regulation of N-cadherin , and acquisition of a fibroblastoid phenotype , consistent with an epithelial-to-mesenchymal transition . Positive_regulation MMP28 TGFB3 18505915 1917932 When cancer cells were cultured on a three-dimensional collagen matrix , TGF-beta1 , TGF-beta2 , and *stimulated* both [pro-MMP] and active MMP secretion and invasion . Positive_regulation MMP28 TGFB3 20304269 2230547 When both the LE and perichondrium are disrupted , [matrix metalloproteinase (MMP)] levels within adjacent chondrocytes are diminished but can be *restored* by exogenous . Positive_regulation MMP28 TGFB3 20648565 2363116 Our results further suggest that EMMPRIN regulates differentiation through an [MMP] *activation* of ( TGFß ) , a known inhibitor of myoblast 's differentiation , as the increased activation and signaling of TGFß by EMMPRIN was attenuated in the presence of marimastat . Positive_regulation MMP28 TGFBI 17327467 1706627 By overexpressing betaig-h3 in human SMMC-7721 hepatoma cells , we discovered that *promoted* cell adhesion , invasion , and [matrix metalloproteinase (MMP)] secretion potential . Positive_regulation MMP28 TGM2 24130925 2714717 Gene silencing of *suppressed* the [MMP] expression by ATRA . Positive_regulation MMP28 THBS1 10900205 736903 Tissue culture and in vitro assays demonstrated that the presence of purified TSR and intact *resulted* in inhibition of [MMP] activity . Positive_regulation MMP28 THBS2 21479427 2009781 In this study , we examined the *role* of in tumor cell invasion and its association with proteolytic proteins , [matrix metalloproteinase (MMP)] and the plasminogen/plasmin system , including urokinase-type plasminogen activator ( uPA ) , in the human pancreatic cancer cell line PANC-1 . Positive_regulation MMP28 TIMP1 10219984 609121 [MMP] activities are precisely *regulated* by endogenous . Positive_regulation MMP28 TIMP1 11960708 932451 We examined the expression patterns of two [MMP] *inhibitors* , tissue inhibitor of metalloproteinase ( ) -2 and TIMP-3 , during critical stages of cardiac development . Positive_regulation MMP28 TIMP1 20665704 2363211 Thus , MSCs are revealed as robust sources of *mediated* [MMP-inhibition] , capable of protecting the perivascular niche from high levels of MMPs even under pathological conditions . Positive_regulation MMP28 TIMP1 21362377 2399808 Tissue inhibitor of metalloproteinase-1 ( ) *inhibits* [matrix metalloproteinase (MMP)] activity and regulates proliferation and apoptosis of a variety of cell types , including pancreatic ß-cells . Positive_regulation MMP28 TIMP1 23631818 2790652 Furthermore , siRNA depletion of or TIMP-2 *prevented* IR-mediated induction of [MMP] activity and cell invasion . Positive_regulation MMP28 TIMP1 7790389 313218 Therefore , the mechanistic aspects of TIMP-1 regulation by retinoic acid in primary cultures of rat calvarial bone cell populations were studied and compared with those of TGF-beta 1 to determine if modulation of would *augment* [MMP] expression . Positive_regulation MMP28 TIMP1 8219937 231826 It is suggested that *contributes* to the regulation of [MMP-activity] involved in the remodeling and turnover of bone . Positive_regulation MMP28 TIMP1 9573338 502390 Enzyme activity of [MMP-C31] and -H19 was *inhibited* by human , TIMP-2 and synthetic MMP inhibitors , BB94 and CT543 , indicating that the catalytic sites of these C. elegans MMPs are structurally closely related with those of mammalian MMPs . Positive_regulation MMP28 TIMP2 15546163 1374865 As expected , overexpression of *inhibited* [matrix metalloprotenase (MMP)] activity and invasion of the tumor cells . Positive_regulation MMP28 TIMP2 15920147 1413571 Reverse transcriptase-polymerase chain reaction demonstrated that increased [MMP] activity was due , at least in part , to increased transcription and that transcripts *increased* in embolic myxomas . Positive_regulation MMP28 TIMP2 18989628 2022023 Concluding , our results provide evidences that RECK and are *involved* in the control of ECM remodeling in distinct phases of osteoblast differentiation by modulating [MMP] activities and a multitude of signaling proteins governs these events . Positive_regulation MMP28 TIMP2 23631818 2790653 Furthermore , siRNA depletion of TIMP-1 or *prevented* IR-mediated induction of [MMP] activity and cell invasion . Positive_regulation MMP28 TIMP2 24418973 2942419 We determined the level of the ECM proteases urokinase-like plasminogen activator ( uPA ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and in the conditioned media . Positive_regulation MMP28 TIMP2 9573338 502391 Enzyme activity of [MMP-C31] and -H19 was *inhibited* by human tissue inhibitor of MMPs (TIMP)-1 , and synthetic MMP inhibitors , BB94 and CT543 , indicating that the catalytic sites of these C. elegans MMPs are structurally closely related with those of mammalian MMPs . Positive_regulation MMP28 TIMP3 10645926 661817 Tissue *inhibitor* of metalloproteinase-3 ( ) , an extracellular matrix associated [MMP] inhibitor , uniquely promotes apoptosis of isolated vascular smooth muscle cells . Positive_regulation MMP28 TLR1 18802113 1964671 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP28 TLR10 18802113 1964679 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP28 TLR2 18802113 1964672 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP28 TLR2 21464389 2417456 Angiotensin II type 1 receptor antagonism appears to inhibit intimal neovascularization in ApoE ( -/- ) mice , partly by reducing mediated inflammatory action and [MMP] *activation* , thus decreasing atherosclerotic plaque growth and increasing plaque instability . Positive_regulation MMP28 TLR3 18802113 1964673 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP28 TLR4 18802113 1964674 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP28 TLR4 21464389 2417457 Angiotensin II type 1 receptor antagonism appears to inhibit intimal neovascularization in ApoE ( -/- ) mice , partly by reducing mediated inflammatory action and [MMP] *activation* , thus decreasing atherosclerotic plaque growth and increasing plaque instability . Positive_regulation MMP28 TLR5 18802113 1964675 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP28 TLR6 18802113 1964680 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP28 TLR7 18802113 1964676 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP28 TLR8 18802113 1964677 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP28 TLR9 18802113 1964678 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP28 TM4SF5 20506553 2307984 We found that TM4SF5 expression facilitated migration , invadopodia formation , [MMP] activation , invasion , and eventually lung metastasis in nude mice , but suppression of with its shRNA *blocked* the effects . Positive_regulation MMP28 TMEM14A 21723035 2461005 *prevented* 4-HPR induced loss of mitochondrial [membrane potential (MMP)] , the release of cytochrome c , and the activation of caspase-3 , but not the generation of reactive oxygen species , suggesting that TMEM14A regulates mitochondrial membrane potential in a ROS independent manner . Positive_regulation MMP28 TMEM14A 21723035 2461092 Suppression of expression using shRNA significantly *increased* apoptosis and [MMP] loss in untreated and 4-HPR treated cells . Positive_regulation MMP28 TMSB4X 16607611 1550820 Because proteinases are important in wound repair , we hypothesized that may *regulate* [matrix metalloproteinase (MMP)] expression in cells that are involved in wound repair . Positive_regulation MMP28 TNC 15178565 1280439 Together with our previous observations , our data suggest that *upregulates* [MMP] expression that cleaves Tn-C into fragments containing the EGF-like domain . Positive_regulation MMP28 TNF 10482270 643773 We also examined the possibility that such MMPs could be produced by brain derived cells , and that [MMP] production by these cells might be *increased* by , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD . Positive_regulation MMP28 TNF 10864917 705824 IL-1beta and each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP28 TNF 11147175 760919 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that may *induce* [MMP] production followed by matrix degradation within foreign body granulomas . Positive_regulation MMP28 TNF 11773040 899396 Isolated RMVECs did not significantly increase [MMP] production directly in response to a hypoxic stimulus , but *required* the presence of exogenous . Positive_regulation MMP28 TNF 12113550 963860 Because elevation of COX-2 mRNA levels enhances the production of prostaglandins , we therefore investigated whether endogenous prostaglandins are involved in the [MMP] mRNA expression that is *enhanced* by . Positive_regulation MMP28 TNF 12606436 1064559 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP28 TNF 12909329 1121944 *mediates* the stretch induced [MMP] genes expression , at least in part , through the JNK pathway . Positive_regulation MMP28 TNF 14673992 1178620 The in vivo data clearly indicated that OSM + overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP28 TNF 15044327 1272754 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to dependent [MMP] *induction* in the macrophages . Positive_regulation MMP28 TNF 15184206 1280570 *causes* increased [MMP] production , but some increased MMP activity is present even in TNFRKO mice . Positive_regulation MMP28 TNF 15201935 1260844 IL-1 and are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP28 TNF 16549372 1582234 and OSM induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP28 TNF 17062332 1637220 To investigate the regulatory effects of fenofibrate on *induced* CD40 expression and [matrix metalloproteinase (MMP)] activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation MMP28 TNF 17469134 1737510 OSM and *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP28 TNF 17507431 1791854 Moreover , [MMP] activity in PCPEC supernatants was significantly *increased* by , presumably due to a diminished expression of TIMP-3 that was similarly observed . Positive_regulation MMP28 TNF 17876544 1796341 A similar augmentation was also observed in *induced* cytokine and [MMP] secretion . Positive_regulation MMP28 TNF 19026560 2001505 suppressed collagen type II and aggrecan , but *increased* [MMP] and cytokine expression in chondrocytes compared to the non stimulated controls . Positive_regulation MMP28 TNF 19435506 2106968 does not *induce* [MMP] expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation MMP28 TNF 20007453 2210583 We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since *induced* superoxide production , [MMP] expression , and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma . Positive_regulation MMP28 TNF 20403361 2267422 While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha , however , [matrix metalloproteinase (MMP)] *activation* of may also be contributory . Positive_regulation MMP28 TNF 23417988 2843301 SUMO-2/3 was knocked down using small interfering RNA in SFs , and *induced* [MMP] production was determined by ELISA . Positive_regulation MMP28 TNF 23417988 2843334 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by TNF-a and selectively control *mediated* [MMP] expression via the NF-?B pathway . Positive_regulation MMP28 TNF 23603294 2795177 Furthermore , infliximab effectively attenuated the *induced* increases in [MMP] expression in cells that make up the BAB . Positive_regulation MMP28 TNF 7543547 314338 Northern hybridization assays showed pretranslational control of PMA- , basic fibroblast growth factor- , and *induced* [MMP] expression . Positive_regulation MMP28 TNF 9014820 405408 In support of this result , stimulation *induced* membrane-type matrix metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation MMP28 TNF 9558121 500077 Recombinant and IL-1beta added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP28 TNF 9631748 512560 *increased* the total [MMP] activity released . Positive_regulation MMP28 TNF 9927150 588409 In general , *stimulated* both [MMP] and TIMP expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation MMP28 TNF 9933437 589381 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by IL-1beta and or down-regulated by IFN-gamma . Positive_regulation MMP28 TSR1 10900205 736906 Tissue culture and in vitro assays demonstrated that the presence of purified and intact TSP1 *resulted* in inhibition of [MMP] activity . Positive_regulation MMP28 TSR2 10900205 736905 Tissue culture and in vitro assays demonstrated that the presence of purified and intact TSP1 *resulted* in inhibition of [MMP] activity . Positive_regulation MMP28 TSR3 10900205 736904 Tissue culture and in vitro assays demonstrated that the presence of purified and intact TSP1 *resulted* in inhibition of [MMP] activity . Positive_regulation MMP28 UMOD 22031601 2547553 Both oxLDL and *increased* [matrix metalloproteinase (MMP)] activity in CVC . Positive_regulation MMP28 VEGFA 10999847 734365 Because of reports that can *enhance* [MMP] expression , we hypothesize that VEGF-KDR interactions may influence MMP expression in the superficial zones of the primate endometrium during the premenstrual phase , and that these interactions play a role in the induction of menstruation . Positive_regulation MMP28 VEGFA 15604273 1346918 First , TIMP-2 can inhibit cell migration after VEGF stimulation by direct inhibition of [MMP] activity induced in *response* to stimulation . Positive_regulation MMP28 VEGFA 16043845 1437871 [MMP] *induction* by was performed in baby hamster kidney ( BHK ) cells . Positive_regulation MMP28 VEGFA 18093986 1889691 Inhibition of VEGFR2 and [ by soluble FMS-like tyrosine kinase-1 ( sFlt1 ) ] *down-regulated* visfatin induced [MMP] induction . Positive_regulation MMP28 VEGFA 19023093 2022641 Therefore , GIT1 mediates *induced* [matrix metalloproteinase (MMP)] activation and ECM degradation by regulating podosome formation . Positive_regulation MMP28 VIPR1 9629281 512223 In contrast , fails to transduce T-cell chemotaxis but *mediates* suppression of chemotaxis and [MMP] expression elicited by some cytokines and chemokines . Positive_regulation MMP28 WASF1 14536061 1152532 is colocalized with ECM degrading enzyme MMP-2 in dorsal ruffles , and WAVE1- , but not WAVE2- , dependent migration *requires* [MMP] activity . Positive_regulation MMP28 WASF2 14536061 1152533 WAVE1 is colocalized with ECM degrading enzyme MMP-2 in dorsal ruffles , and WAVE1- , but not , dependent migration *requires* [MMP] activity . Positive_regulation MMP28 WDR61 23911909 2840317 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Positive_regulation MMP28 WNT1 22328140 2629893 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Positive_regulation MMP28 WNT11 22328140 2629894 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Positive_regulation MMP28 WNT16 22328140 2629899 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Positive_regulation MMP28 WNT2 22328140 2629895 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Positive_regulation MMP28 WNT3 22328140 2629896 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Positive_regulation MMP28 WNT4 22328140 2629897 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Positive_regulation MMP28 WNT5A 21035559 2370153 We have previously reported that interleukin-1ß (IL-1ß) up-regulates the expression of Wnt-5A and the activation of signaling *induces* [matrix metalloproteinase (MMP)] through the c-Jun N-terminal kinase pathway in condylar chondrocytes (CCs) of the temporomandibular joint ( TMJ ) . Positive_regulation MMP28 WNT6 22328140 2629898 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Positive_regulation MMP3 CAPN8 16574073 1543507 The inhibitors , ALLN ( calpain inhibitor I ) and calpeptin , did not affect the intracellular expression of MMP-3 , but *reduced* the secretion of [MMP-3] in a concentration dependent manner . Positive_regulation MMP3 CAPN8 16574073 1543536 These findings suggest that , particularly mu-calpain , *regulates* [MMP-3] release by rheumatic synovial cells , in addition to exerting its own degradative action on cartilage . Positive_regulation MMP3 CAPN8 21911754 2497104 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP3 CAPN8 21964156 2525882 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP3 CAPN8 22316244 2553388 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP3 CTGF 18632843 1979323 In conclusion , upregulation of inhibits BMP-7 signal transduction in the diabetic kidney and *contributes* to altered gene transcription , reduced [MMP] activity , glomerular basement membrane thickening , and albuminuria , all of which are hallmarks of diabetic nephropathy . Positive_regulation MMP3 CTGF 23827951 2820816 stimulation *resulted* in the significant production of IL-6 , IL-8 , C-C motif ligand 2 (CCL2) , CCL20 , MMP-1 and [MMP-3] in FLSs in the presence , but not in the absence , of IL-1ß . Positive_regulation MMP3 EPHB2 14709335 1196662 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP3 EPHB2 15389548 1304767 Like NFLC , induction of urokinase plasminogen activator (uPAR) , [transin/matrix metalloproteinase 3 (MMP3)] , Fra-1 and transforming growth factor beta 1 ( TGF beta 1 ) *required* collaborative and JNK signaling while the increased expression of cortexin , rat collapsin response mediator protein 4 ( rCRMP4 ) , rat growth and transformation dependent protein ( RGT ) , and synapsin II required neither mitogen activated protein kinase (MAPK) pathway . Positive_regulation MMP3 EPHB2 17348021 1748236 Moreover , the expression of [MMP-3] and -14 , and collagen contraction is partially *prevented* by and Jnk inhibitors . Positive_regulation MMP3 EPHB2 18340449 1932030 Using chondrosarcoma cells stimulated with IL-1beta , the effects of GLN on the mRNA and protein levels of [MMP-3] , the *activation* of JNK , , p38 , NF-kappaB , and AP-1 , the nuclear translocation of NF-kappaB/Rel family members , and PI3-kinase/Akt activation were studied . Positive_regulation MMP3 EPHB2 20843518 2353072 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and *dependent* [MMP] expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation MMP3 EPHB2 24012928 2862359 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an [MMP] *inhibitor* , or PD98059 ( 50 µM ) , an inhibitor , also suppressed it . Positive_regulation MMP3 IGFBP1 15590975 1346161 Cell numbers were increased only by 100 nM IGFBP-1 isoforms ( P < 0.05 ) , whereas [MMP] levels released from term cells were optimally *increased* by 1-10 nM . Positive_regulation MMP3 IL1B 10660603 664591 By contrast , the mediated *increase* in MMP-1 and [MMP-3] protein levels could not be suppressed by rapamycin . Positive_regulation MMP3 IL1B 10679106 668791 Lipoxin A4 inhibits *induced* IL-6 , IL-8 , and [matrix metalloproteinase-3] production in human synovial fibroblasts and enhances synthesis of tissue inhibitors of metalloproteinases . Positive_regulation MMP3 IL1B 10679106 668794 At nanomolar concentrations , LXA4 inhibited these IL-1 beta responses with reduction of IL-6 and IL-8 synthesis , by 45 +/- 7 % and 75 +/- 11 % , respectively , and prevented *induced* [MMP-3] synthesis without significantly affecting MMP-1 levels . Positive_regulation MMP3 IL1B 10688614 670019 Finally , IL-13 inhibited *induced* matrix metalloproteinase (MMP)-1 and [MMP-3] production and enhanced tissue inhibitor of metalloproteinase ( TIMP ) -1 generation from NF ; Positive_regulation MMP3 IL1B 10727770 678131 and TPA alone *induced* [MMP] activity in HIG-82 cells . Positive_regulation MMP3 IL1B 10864917 705853 and TNF-alpha each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP3 IL1B 10895370 711614 In support of this result , stimulation *induced* the expression of membrane type matrix-metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation MMP3 IL1B 11132772 760231 Casein zymography confirmed that *stimulated* stromlysin ( [matrix metalloproteinase 3] ; Positive_regulation MMP3 IL1B 11174072 763238 MMP-3 was found to be the most abundant transcript , *induced* a 12-fold upregulation of [MMP-3] levels compared to control , and 7-fold of TSG-6 . Positive_regulation MMP3 IL1B 11327259 807602 A decrease in IL-1alpha , , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP3 IL1B 11467889 840805 In all cases , PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on *induction* of [MMP] expression . Positive_regulation MMP3 IL1B 11694815 877152 and transforming growth factor-beta1 ( TGF-beta1 ) *increased* [MMP-3] and TIMP-3 expressions in A549 cells in a time- and concentration dependent manner . Positive_regulation MMP3 IL1B 11694815 877154 mainly *augmented* [MMP-3] expression , while TGF-beta1 mainly augmented TIMP-3 expression . Positive_regulation MMP3 IL1B 11853088 913330 *induced* the expression of the collagenase-1 and [stromelysin-1] genes . Positive_regulation MMP3 IL1B 11997239 939304 produced a dose dependent *increase* in [MMP] activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min . Positive_regulation MMP3 IL1B 12384923 999426 Expression of [MMP-3] was higher in vitro than in vivo and was *up-regulated* by . Positive_regulation MMP3 IL1B 12428247 1014856 Ciprofloxacin enhances the *stimulation* of [matrix metalloproteinase 3] expression by in human tendon derived cells . Positive_regulation MMP3 IL1B 12440501 1016966 *increased* [MMP-3] expression by 44 % and inhibited AGG expression by 16 % , but PG-concentration was reduced by 7 % . Positive_regulation MMP3 IL1B 12527330 1048283 *increased* IL-6 , IL-8 , MIP-1beta , NO , PGE ( 2 ) and [MMP-3] productions , but inhibited AGG and TIMP-1 synthesis . Positive_regulation MMP3 IL1B 12568957 1057197 also *stimulated* [MMP-1 and -3] protein secretion . Positive_regulation MMP3 IL1B 12825130 1104470 In human colonic SEMFs , MMP-3 secretion and [MMP-3] mRNA expression were *induced* by IL-17 , , and TNF-alpha . Positive_regulation MMP3 IL1B 12825130 1104519 Colonic SEMFs actively secreted [MMP-3] in *response* to IL-17 , , and TNF-alpha . Positive_regulation MMP3 IL1B 12880581 1115754 Gene expressions of type I and II collagen , metalloproteinase-1 and -3 ( MMP-1 and -3 ) , and tissue inhibitor of metalloproteinase-1 ( TIMP-1 ) as well as the *induced* gene expressions of [MMP-1 and -3] were analyzed by reverse transcription-polymerase chain reaction ( RT-PCR ) . Positive_regulation MMP3 IL1B 12912854 1129493 We conclude that *induces* gastric epithelial cell [MMP-3] secretion , contributing to epithelial tissue destruction during H pylori infection . Positive_regulation MMP3 IL1B 12913942 1129704 A1S2 was a potent inhibitor of basal and *stimulated* [MMP-3] production . Positive_regulation MMP3 IL1B 12960035 1164228 Thus , our data imply that *induced* MMPs and particularly [MMP-3] may up-regulate IGFBP-1 by disrupting the actin cytoskeleton as a result of ECM degradation . Positive_regulation MMP3 IL1B 14872494 1208458 Preincubation with anti-CD44 antibody , which suppressed IL-1beta stimulated MMPs , reversed the inhibitory effect of HA on [MMP] production that was *induced* by in normal and OA cartilage . Positive_regulation MMP3 IL1B 14872494 1208464 This study demonstrates that HA effectively inhibits *stimulated* production of MMP-1 , [MMP-3] , and MMP-13 , which supports the clinical use of HA in the treatment of OA . Positive_regulation MMP3 IL1B 14981131 1214265 Prostaglandin E2 regulates *induced* [matrix metalloproteinase-3] production in human gingival fibroblasts . Positive_regulation MMP3 IL1B 14981131 1214267 In HGF from healthy gingiva , PGE2 down-regulated *induced* [MMP-3] production , whereas in HGF from periodontitis patients , PGE2 enhanced it . Positive_regulation MMP3 IL1B 14981131 1214269 Butaprost ( an EP2 agonist ) and ONO-AE1-329 ( an EP4 agonist ) suppressed *induced* [MMP-3] production , and 17-phenyl-omega-trinor PGE2 ( an EP1 agonist ) mimicked the PGE ( 2 ) effect in HGF from healthy and periodontally diseased tissues , respectively . Positive_regulation MMP3 IL1B 14981131 1214270 Analysis of these data suggests that , in HGF from healthy tissue , *induced* [MMP-3] production is down-regulated by PGE2 via EP2 and EP4 receptors , whereas in cells from periodontally diseased tissue , IL-1beta induced MMP-3 production is up-regulated via EP1 receptors . Positive_regulation MMP3 IL1B 14981131 1214271 Different regulation of *induced* [MMP-3] production by PGE2 between healthy and periodontally diseased tissues may be involved in the pathogenesis of periodontal disease . Positive_regulation MMP3 IL1B 15094140 1238237 TNFalpha , IL-1alpha , and *led* to marked increases in MMP-1 and [MMP-3] release ( up to 4.2-fold and 547-fold , respectively ) by synovial fibroblasts , whereas secretion of MMP-13 was induced by concomitant administration of TNFalpha and IL-1beta . Positive_regulation MMP3 IL1B 15188355 1256658 The mean fold increases in A-SAA induced MMP-1 and MMP-3 production were 2.6 and 10.6 , respectively , compared with 7.6-fold and 41.9-fold increases in *induced* MMP-1 and [MMP-3] production . Positive_regulation MMP3 IL1B 15383690 1299069 Hyaluronate inhibits the *induced* expression of matrix metalloproteinase (MMP)-1 and [MMP-3] in human synovial cells . Positive_regulation MMP3 IL1B 15383690 1299073 Expression of MMP-1 and [MMP-3] mRNAs was *induced* by . Positive_regulation MMP3 IL1B 15389872 1324239 However , pretreatment of anti-eotaxin-1 antibody significantly decreased the [MMP-3] expression *induced* by . Positive_regulation MMP3 IL1B 15659840 1350279 *induced* a decrease in collagen type II and upregulation of [MMP-3] in a time dependent manner . Positive_regulation MMP3 IL1B 15659840 1350281 Taken together , these results confirmed an *mediated* upregulation of proinflammatory [MMP-3] in chondrocytes via an NF-kappaB activation mechanism . Positive_regulation MMP3 IL1B 15778394 1385092 Furthermore , *induced* IL-8 , IL-6 , and [matrix metalloproteinase-3] protein production was significantly inhibited in DN MKK3/DN MKK6 transfected cells . Positive_regulation MMP3 IL1B 15929608 1414356 Thus , the aim of the present study was to analyze the effect of CS and HA ( 500-730 kDa ) on [MMP-3] synthesis *induced* by in chondrocytes from patients with hip OA . Positive_regulation MMP3 IL1B 15929608 1414357 The results revealed that both CS and HA ( 500-730 kDa ) inhibited [MMP-3] synthesis *induced* by in human OA chondrocytes . Positive_regulation MMP3 IL1B 15950496 1434326 In both cell systems matrix metalloproteinase-1 (MMP-1) , [MMP-3] and MMP-13 were strongly *induced* by , without significant induction of MMP-2 . Positive_regulation MMP3 IL1B 16364234 1504738 This fucoidan is able to inhibit gelatinase A secretion and [stromelysin 1] *induction* by on dermal fibroblasts in culture . Positive_regulation MMP3 IL1B 16449361 1573864 Production of MMP-1 and [MMP-3] by RSF was *stimulated* by . Positive_regulation MMP3 IL1B 16449361 1573883 HA at > or =2 mg/ml significantly inhibited [MMP] production *induced* by in a dose dependent manner . Positive_regulation MMP3 IL1B 16449361 1573905 Inhibition studies revealed the requirement of NF-kappaB , p38 and c-jun NH2-terminal kinase ( JNK ) for *induced* [MMP] production . Positive_regulation MMP3 IL1B 16522689 1567945 *stimulated* MMP-1 ( 5.6-fold ) , MMP-2 ( 2.8-fold ) , and [MMP-3] ( 75-fold ) gene expression , but not EMMPRIN , over levels in control cells ( P < 0.05 ) . Positive_regulation MMP3 IL1B 16893421 1597148 *enhanced* [MMP-3] mRNA levels while LPS increased the MMP-3 , -9 , -12 , -13 and -14 mRNAs . Positive_regulation MMP3 IL1B 17198194 1680600 In human pancreatic myofibroblasts , [MMP-3] secretion and mRNA expression were *induced* by interleukin (IL)-17 , , and tumor necrosis factor (TNF) -alpha , respectively . Positive_regulation MMP3 IL1B 17198194 1680614 Pancreatic periacinar myofibroblasts actively secrete [MMP-3] in *response* to IL-17 , , and TNF-alpha . Positive_regulation MMP3 IL1B 17328062 1711906 SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on *stimulated* [MMP] production and collagen degradation . Positive_regulation MMP3 IL1B 17599750 1774569 Cyclosporin A ( CSA ) , a Cn inhibitor , inhibited spontaneous and *stimulated* production of NO , MMP-1 , and [MMP-3] in chondrocytes . Positive_regulation MMP3 IL1B 17876544 1796336 Both IL-17A and IL-17F augmented *induced* secretion of IL-6 , IL-8 , LIF , MMP-1 , and [MMP-3] . Positive_regulation MMP3 IL1B 17923423 1888935 TNF-alpha and both *caused* an increase in protease transcription ( MMP-3 , MMP-13 , ADAMTS4 and ADAMTS5 ) and in pro-inflammatory enzymes , inducible nitric oxide synthase and cyclooxygenase (COX)-2 , as well as a decrease in matrix protein transcription , including collagen II , aggrecan , fibromodulin and link protein ( IL-1beta only ) , and an increase in [MMP-3] and MMP-9 secretion . Positive_regulation MMP3 IL1B 17925024 1835415 These findings demonstrate , for the first time , that glucosamine inhibits *stimulated* [MMP] production in human chondrocytes by affecting MAPK phosphorylation . Positive_regulation MMP3 IL1B 17940116 1849321 We hypothesized that and TNF-alpha may *induce* matrix metalloproteinase (MMP)-1 and [MMP-3] activity to promote PTD by degrading decidual and fetal membranes and cervical extracellular matrix . Positive_regulation MMP3 IL1B 17940116 1849344 Compared with basal outputs by DCs incubated with E2 , TNF-alpha enhanced MMP-1 and MMP-3 secretion by 14 +/- 3- and 9 +/- 2-fold , respectively , and *increased* MMP-1 and [MMP-3] secretion by 13 +/- 3- and 19 +/- 2-fold , respectively ( P < 0.05 ) . Positive_regulation MMP3 IL1B 17940116 1849346 SB203580 suppressed TNF-alpha- and *induced* MMP-1 and [MMP-3] secretion by severalfold . Positive_regulation MMP3 IL1B 18240213 1871416 and TNFalpha *caused* increased release of chitinase 3-like protein 1 (CHI3L1) , CHI3L2 , complement factor B , [matrix metalloproteinase 3] , ECM-1 , haptoglobin , serum amyloid A3 , and clusterin . Positive_regulation MMP3 IL1B 18340449 1932041 GLN inhibited the expression and the synthesis of [MMP-3] *induced* by , and that inhibition was mediated at the level of transcription involving both the NF-kappaB and AP-1 transcription factors . Positive_regulation MMP3 IL1B 18403593 1899538 DHA significantly decreased VSMC migration/proliferation *induced* by as well as [fibrinolytic/MMP] activity . Positive_regulation MMP3 IL1B 18449943 1932934 Astrocytes constitutively expressed MMP-11 , MMP-14 , and MMP-2 and showed induction of [MMP-3] in *response* to but did not respond to lipopolysaccharide (LPS) . Positive_regulation MMP3 IL1B 18495175 1917417 In addition , Western blot analysis and gelatin zymography revealed that *activated* [matrix metalloproteinase (MMP)-1 and -3] in FLS . Positive_regulation MMP3 IL1B 18535174 1928805 *stimulated* [MMP] mRNA synthesis in wild-type , but not in IL-1RI-null cardiac fibroblasts . Positive_regulation MMP3 IL1B 18570937 1930041 Additionally , estrogen up-regulates [MMP-3] only in the *presence* of . Positive_regulation MMP3 IL1B 19056796 2017694 Cordycepin inhibits *induced* MMP-1 and [MMP-3] expression in rheumatoid arthritis synovial fibroblasts . Positive_regulation MMP3 IL1B 19056796 2017696 In this study , we aimed at the inhibitory effect of cordycepin on *induced* MMP-1 and [MMP-3] expression as well as the molecular basis using RA synovial fibroblasts ( RASFs ) . Positive_regulation MMP3 IL1B 19056796 2017698 Cordycepin inhibited *induced* MMP-1 and [MMP-3] expressions in RASFs in a dose dependent manner . Positive_regulation MMP3 IL1B 19056796 2017722 Cordycepin is a potent inhibitor of *induced* chemokine production and [MMP] expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs . Positive_regulation MMP3 IL1B 19107653 2018863 Results showed that FGF2 and IL-1beta both increased MMP-1 and -13 expression , while also *increased* [MMP-3] mRNA levels . Positive_regulation MMP3 IL1B 19542681 2099205 *induced* [MMP] production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ) , p38 kinase , and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase (MAPK) family signal transduction molecules . Positive_regulation MMP3 IL1B 20380722 2273566 In combination , TGF-beta and PDGF ( 2GF ) synergistically augmented TNFalpha- or *induced* [matrix metalloproteinase 3 (MMP3)] , IL6 , IL8 , and macrophage inflammatory protein 1 alpha ( MIP1alpha ) secretion by FLS . Positive_regulation MMP3 IL1B 20380722 2273567 Individually , neither growth factor significantly potentiated TNFalpha or *induced* [MMP3] secretion , and only slightly enhanced IL6 . Positive_regulation MMP3 IL1B 20403707 2282293 *induced* [MMP] production was significantly augmented in the presence of sIL-6R . Positive_regulation MMP3 IL1B 20538267 2284713 This study was conducted to evaluate the efficacy of hesperetin in regulating *induced* production of the [matrix metalloproteinase (MMP)-3] and IL-6 in human synovial cell line , SW982 . Positive_regulation MMP3 IL1B 20538267 2284715 Treatment with hesperetin at 1 or 10 microM significantly ( P < 0.05 ) inhibited *induced* [MMP-3] and IL-6 production when measured by enzyme linked immunosorbent assay ( ELISA ) . Positive_regulation MMP3 IL1B 21344389 2480449 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Positive_regulation MMP3 IL1B 22792188 2628390 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation MMP3 IL1B 7704454 297584 Whereas *stimulated* the production of [MMP-3] , IL-4 and IL-6 had no effect on enzyme activity . Positive_regulation MMP3 IL1B 8895151 392425 Human recombinant *increased* [MMP-3] levels in primary chondrocyte cultures . Positive_regulation MMP3 IL1B 8945720 400352 and lipopolysaccharide also *stimulated* the production of [matrix metalloproteinase-3] ( stromelysin-1 ) in astrocytes . Positive_regulation MMP3 IL1B 9203094 440260 In conclusion , the results of this study demonstrate that *upregulates* [MMP-3] in human PDL cells on both an mRNA and a protein level . Positive_regulation MMP3 IL1B 9558121 500106 Recombinant TNF-alpha and added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP3 IL1B 9821179 548127 The inflammatory cytokine did not *induce* [MMP] or TIMP expression . Positive_regulation MMP3 IL1B 9827576 550886 Here , we describe the influence of heparin ( s ) on the *induced* expression of collagenase ( matrix metalloproteinase-1 , MMP-1 ) , [stromelysin-1] ( matrix metalloproteinase-3 , MMP-3 ) and tissue inhibitor of matrix metalloproteinase-1 ( TIMP-1 ) in human gingival fibroblasts (HGF) . Positive_regulation MMP3 IL1B 9832620 551980 *enhanced* the production of IL-6 and [stromelysin-1] , and the surface expression of ICAM-1 , in a manner similar to that in the parental FLSs . Positive_regulation MMP3 IL1B 9832620 551982 SB203580 , a specific inhibitor of p38 MAP kinase , significantly inhibited *induced* IL-6 and [stromelysin-1] production by both parental FLSs and MH7A cells ; Positive_regulation MMP3 IL1B 9890433 585424 A beta , but not or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells , as well as *increased* the expression of the well-known activator of MMP-2 , membrane-type ( MT ) [-MMP] . Positive_regulation MMP3 IL1B 9933437 589410 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by and TNF-alpha or down-regulated by IFN-gamma . Positive_regulation MMP3 MAP2K6 12060661 975667 Activation of endogenous or adenovirally expressed p38 alpha by adenovirally delivered constitutively active MKK3b and also *enhanced* MMP-1 and [MMP-3] expression and augmented the up-regulatory effect of ERK1/2 activation on the expression of these MMPs . Positive_regulation MMP3 MAP2K6 17348021 1748242 Moreover , the expression of [MMP-3] and -14 , and collagen contraction is partially *prevented* by and Jnk inhibitors . Positive_regulation MMP3 MAP2K6 19833163 2196188 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP3 MAP2K6 20545600 2308482 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP3 MAP2K6 22253074 2599946 avß5 or a6ß1 monoclonal antibody ( mAb ) , focal adhesion kinase ( FAK ) inhibitor , and inhibitors ( PD98059 and U0126 ) *inhibited* the Cyr61 induced increase of the migration and [MMP-3] up-regulation of OSCC cells . Positive_regulation MMP3 MAP2K6 22310287 2719016 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP3 PLAT 19608750 2142717 *induces* [stromelysin-1] ( MMP-3 ) in endothelial cells through activation of lipoprotein receptor related protein . Positive_regulation MMP3 PLAU 11027463 738929 The following activation mechanism for proteinase might occur : coexpressed with MMP-9 *activated* plasminogen , and plasmin activated proMMP-3 , which was secreted depending upon inflammatory infiltration , and then [MMP-3] activated proMMP-9 , resulting in colorectal cancer progression and metastasis . Positive_regulation MMP3 PLAU 20609072 2303962 Moreover , and tissue inhibitor of metalloproteinase ( TIMP ) -3 were *involved* in [MMP-3] regulation during endometriosis . Positive_regulation MMP3 PODXL 17616675 1769341 These findings suggest that leads to increased in vitro migration and invasion , *increased* [MMP] expression , and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MMP3 TGM2 24130925 2714731 Gene silencing of *suppressed* the [MMP] expression by ATRA . Positive_regulation MMP3 TLR7 18802113 1964816 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP3 TNF 10482270 643787 We also examined the possibility that such MMPs could be produced by brain derived cells , and that [MMP] production by these cells might be *increased* by , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD . Positive_regulation MMP3 TNF 10642592 660968 The generation of soluble was *essential* for the induction of [MMP-3] in disc cocultures , which in turn is required for the generation of a macrophage chemoattractant and subsequent macrophage infiltration . Positive_regulation MMP3 TNF 10864917 705852 IL-1beta and each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP3 TNF 11147175 760933 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that may *induce* [MMP] production followed by matrix degradation within foreign body granulomas . Positive_regulation MMP3 TNF 11174072 763236 Quantitative RT-PCR reaction was used to estimate the messenger RNA ( mRNA ) of three different metabolites [ *stimulated* gene 6 ( TSG-6 ) , [stromelysin-1] ( MMP-3 ) and aggrecan (AGG) ] . Positive_regulation MMP3 TNF 11773040 899410 Isolated RMVECs did not significantly increase [MMP] production directly in response to a hypoxic stimulus , but *required* the presence of exogenous . Positive_regulation MMP3 TNF 11773040 899415 *increased* the expression of MT1-MMP , [MMP-3] , and MMP-9 in these cells . Positive_regulation MMP3 TNF 12113550 963854 *increased* MMP-1 , [MMP-3] and MMP-13 mRNA levels in both a time dependent ( 0-24 h ) and a dose dependent ( 0.1-10 ng/ml ) manner . Positive_regulation MMP3 TNF 12113550 963874 Because elevation of COX-2 mRNA levels enhances the production of prostaglandins , we therefore investigated whether endogenous prostaglandins are involved in the [MMP] mRNA expression that is *enhanced* by . Positive_regulation MMP3 TNF 12206592 983454 In addition , MMP-1 and [MMP-3] production , *induced* by IL-1beta , or EGF , was strongly reduced by the presence of the glucocorticoid dexamethasone . Positive_regulation MMP3 TNF 12606436 1064589 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP3 TNF 12825130 1104468 In human colonic SEMFs , MMP-3 secretion and [MMP-3] mRNA expression were *induced* by IL-17 , IL-1beta , and . Positive_regulation MMP3 TNF 12825130 1104499 A c-Jun/activating protein-1 (AP-1) inhibitor , curcumin , reduced the IL-17- , IL-1beta- , and *induced* [MMP-3] mRNA expression , and mitogen activated protein (MAP) kinase inhibitors ( U0126 , PD098059 , and SB203580 ) also blocked MMP-3 secretion . Positive_regulation MMP3 TNF 12825130 1104517 Colonic SEMFs actively secreted [MMP-3] in *response* to IL-17 , IL-1beta , and . Positive_regulation MMP3 TNF 12909329 1121958 *mediates* the stretch induced [MMP] genes expression , at least in part , through the JNK pathway . Positive_regulation MMP3 TNF 14673992 1178648 The in vivo data clearly indicated that OSM + overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP3 TNF 15044327 1272768 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to dependent [MMP] *induction* in the macrophages . Positive_regulation MMP3 TNF 15094140 1238235 , IL-1alpha , and IL-1beta *led* to marked increases in MMP-1 and [MMP-3] release ( up to 4.2-fold and 547-fold , respectively ) by synovial fibroblasts , whereas secretion of MMP-13 was induced by concomitant administration of TNFalpha and IL-1beta . Positive_regulation MMP3 TNF 15184206 1280584 *causes* increased [MMP] production , but some increased MMP activity is present even in TNFRKO mice . Positive_regulation MMP3 TNF 15201935 1260872 IL-1 and are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP3 TNF 16549372 1582262 and OSM induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP3 TNF 16565381 1538928 IL-1 and *induction* of [matrix metalloproteinase-3] by c-Jun N-terminal kinase in trabecular meshwork . Positive_regulation MMP3 TNF 16574073 1543452 Mu-calpain is involved in the regulation of *induced* [matrix metalloproteinase-3] release in a rheumatoid synovial cell line . Positive_regulation MMP3 TNF 16574073 1543496 ( TNF-alpha ) stimulation *induced* increased expression of mu-calpain , m-calpain , and [MMP-3] in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation MMP3 TNF 16574073 1543525 Down-regulation of mu- but not m-calpain by small interfering RNAs abolished *induced* [MMP-3] release from the synovial cells . Positive_regulation MMP3 TNF 16677108 1558941 Pretreatment of HMECs for 2 days with BE potently prevented *induced* expression and activity of [MMP-3] , MMP-10 , and MMP-12 . Positive_regulation MMP3 TNF 16911716 1601756 *stimulated* [MMP-1 and -3] protein secretion in a time dependent manner and stimulated MMP-1 , -2 and -3 mRNA levels in a time dependent manner ( P < 0.05 ) . Positive_regulation MMP3 TNF 17062332 1637234 To investigate the regulatory effects of fenofibrate on *induced* CD40 expression and [matrix metalloproteinase (MMP)] activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation MMP3 TNF 17223661 1765550 Reduction of proliferation and induction of IL6 , IL8 and MMP-1 were solely mediated by TNF-R1 , whereas PGE ( 2 ) and [MMP-3] secretion was *mediated* by both . Positive_regulation MMP3 TNF 17436000 1777989 Stimulation of SW1353 cells with activin A suppressed IL-1alpha induced , but not *induced* , [MMP-3] expression . Positive_regulation MMP3 TNF 17469134 1737538 OSM and *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP3 TNF 17507431 1791868 Moreover , [MMP] activity in PCPEC supernatants was significantly *increased* by , presumably due to a diminished expression of TIMP-3 that was similarly observed . Positive_regulation MMP3 TNF 17520672 1772918 Interferon-gamma regulation of *induced* [matrix metalloproteinase 3] expression and migration of human glioma T98G cells . Positive_regulation MMP3 TNF 17525194 1746106 , in combination with IL-1alpha or IL-1beta , produces highly synergistic [MMP-3] *increases* . Positive_regulation MMP3 TNF 17591882 1764536 and interleukin (IL)-1alpha are efficacious *inducers* of [MMP-3] in TM . Positive_regulation MMP3 TNF 17591882 1764539 The p38 MAP kinase inhibitor SB202190 diminished [MMP-3] *induction* by at all times and at 24 hours by IL-1alpha but potentiated the IL-1alpha induced increase in MMP-3 at later times . Positive_regulation MMP3 TNF 17876544 1796355 A similar augmentation was also observed in *induced* cytokine and [MMP] secretion . Positive_regulation MMP3 TNF 17923423 1888934 and IL-1beta both *caused* an increase in protease transcription ( MMP-3 , MMP-13 , ADAMTS4 and ADAMTS5 ) and in pro-inflammatory enzymes , inducible nitric oxide synthase and cyclooxygenase (COX)-2 , as well as a decrease in matrix protein transcription , including collagen II , aggrecan , fibromodulin and link protein ( IL-1beta only ) , and an increase in [MMP-3] and MMP-9 secretion . Positive_regulation MMP3 TNF 17940116 1849320 We hypothesized that IL-1beta and may *induce* matrix metalloproteinase (MMP)-1 and [MMP-3] activity to promote PTD by degrading decidual and fetal membranes and cervical extracellular matrix . Positive_regulation MMP3 TNF 17940116 1849343 Compared with basal outputs by DCs incubated with E2 , enhanced MMP-1 and MMP-3 secretion by 14 +/- 3- and 9 +/- 2-fold , respectively , and IL-1beta *increased* MMP-1 and [MMP-3] secretion by 13 +/- 3- and 19 +/- 2-fold , respectively ( P < 0.05 ) . Positive_regulation MMP3 TNF 18240213 1871415 IL-1beta and *caused* increased release of chitinase 3-like protein 1 (CHI3L1) , CHI3L2 , complement factor B , [matrix metalloproteinase 3] , ECM-1 , haptoglobin , serum amyloid A3 , and clusterin . Positive_regulation MMP3 TNF 18496696 1965698 Here we show that epigallocatechin-3-Gallate ( EGCG ) suppresses *induced* production of MMP-1 and [MMP-3] in RA synovial fibroblasts , which was accompanied by inhibition of mitogen activated protein kinase (MAPK) and activator protein-1 (AP-1) pathways . Positive_regulation MMP3 TNF 18496696 1965700 EGCG treatment resulted in dose dependent inhibition of *induced* production of MMP-1 and [MMP-3] at the protein and mRNA levels in RA synovial fibroblast . Positive_regulation MMP3 TNF 18629644 2028056 Trichostatin A , a histone-deacetylase inhibitor , reduced IL-1 beta induced MMP-1 and MMP-3 mRNA expression , and suppressed *induced* [MMP-3] mRNA expression . Positive_regulation MMP3 TNF 19026560 2001519 suppressed collagen type II and aggrecan , but *increased* [MMP] and cytokine expression in chondrocytes compared to the non stimulated controls . Positive_regulation MMP3 TNF 19435506 2106982 does not *induce* [MMP] expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation MMP3 TNF 19778432 2163661 *increased* [matrix metalloproteinase (MMP)-3] and a disintegrin and metalloproteinase with thrombospondin motifs ( ADAMTS)-4 mRNA expression , whereas collagen type I was decreased , and aggrecan , collagen type II as well as MMP-1 , -2 , -13 and ADAMTS-5 were variably affected . Positive_regulation MMP3 TNF 20007453 2210597 We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since *induced* superoxide production , [MMP] expression , and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma . Positive_regulation MMP3 TNF 20403361 2267436 While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha , however , [matrix metalloproteinase (MMP)] *activation* of may also be contributory . Positive_regulation MMP3 TNF 22155307 2531183 HO-1 induction significantly reduced the expression of matrix metalloproteinase (MMP)-1 , MMP-2 and [MMP-3] , and the production of pro-inflammatory cytokines such as and IL-6 whereas IL-10 levels *increased* . Positive_regulation MMP3 TNF 22393877 2668873 E ( 2 ) possessed a suppressive effect for apoptosis and a promotive effect for *induced* [matrix metalloproteinase (MMP)-3] production on the synovial fibroblasts . Positive_regulation MMP3 TNF 22393877 2668874 The present data suggest that E ( 2 ) has adverse effects on the pathogenesis of RA as a result of unregulated cell death , increased *induced* [MMP-3] production , and CCL13 overproduction , subsequently resulting in the disease progression of RA . Positive_regulation MMP3 TNF 23257246 2737294 Resveratrol dose-dependently inhibited *induced* cyclooxygenase-2 (COX-2) , MMP-1 , [MMP-3] , MMP-13 and PGE ( 2 ) production in human chondrocytes . Positive_regulation MMP3 TNF 23328930 2798703 The present study was designed to investigate the effects of resveratrol on *induced* inflammatory cytokines production of IL-1ß and [MMP3] in Rheumatoid arthritis ( RA ) Fibroblast-like synoviocytes ( FLS ) and further to explore the role of PI3K/Akt signaling pathway by which resveratrol modulates those cytokines production . Positive_regulation MMP3 TNF 23328930 2798705 Activation of PI3K/Akt signaling pathway exists in *induced* production of IL-1ß and [MMP3] on RA FLS , which is hampered by PI3K inhibitor LY294002 . Positive_regulation MMP3 TNF 23328930 2798710 Resveratrol attenuates *induced* production of IL-1ß and [MMP-3] via inhibition of PI3K-Akt signaling pathway in RA FLS , suggesting that resveratrol plays an anti-inflammatory role and might have beneficial effects in preventing and treating RA . Positive_regulation MMP3 TNF 23370854 2818514 We here investigated the effect of CK ( 0-5 µM ) on *induced* MMP-1 , [MMP-3] , and MMP-13 and TIMP-1 production from RA fibroblast-like synoviocytes ( FLS ) and determined the inhibitory effect of CK on osteoclastogenesis from RAW264.7 cells co-cultured with RA-FLS and from human CD14+ monocytes . Positive_regulation MMP3 TNF 23417988 2843315 SUMO-2/3 was knocked down using small interfering RNA in SFs , and *induced* [MMP] production was determined by ELISA . Positive_regulation MMP3 TNF 23417988 2843348 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by TNF-a and selectively control *mediated* [MMP] expression via the NF-?B pathway . Positive_regulation MMP3 TNF 23603294 2795171 The expression of MMP-1 , [MMP-3] , and MMP-9 increased in the *presence* of , and the addition of infliximab reversed the increase . Positive_regulation MMP3 TNF 23603294 2795191 Furthermore , infliximab effectively attenuated the *induced* increases in [MMP] expression in cells that make up the BAB . Positive_regulation MMP3 TNF 24349530 2881290 Inhibitors of cPLA2a enzyme activity ( AVX002 , ATK ) significantly reduced *induced* cellular release of AA , PGE2 , IL8 and [MMP3] . Positive_regulation MMP3 TNF 7543547 314352 Northern hybridization assays showed pretranslational control of PMA- , basic fibroblast growth factor- , and *induced* [MMP] expression . Positive_regulation MMP3 TNF 7636301 317457 This mutant markedly *induced* collagenase and [stromelysin-1] gene expression in dermal fibroblasts , the maximal activation ( up to 42-fold ) being 65 % -89 % of that noted with wild-type human TNF-alpha . Positive_regulation MMP3 TNF 7921541 272895 *Induction* of [stromelysin-1] and collagenase synthesis in fibrochondrocytes by . Positive_regulation MMP3 TNF 8045973 266926 Both interleukin-1 alpha and *stimulated* the secretion of MMP-1 , [MMP-3] , and MMP-9 , but not MMP-2 , from the cells in a concentration dependent manner . Positive_regulation MMP3 TNF 9014820 405422 In support of this result , stimulation *induced* membrane-type matrix metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation MMP3 TNF 9558121 500105 Recombinant and IL-1beta added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP3 TNF 9631748 512574 *increased* the total [MMP] activity released . Positive_regulation MMP3 TNF 9927150 588423 In general , *stimulated* both [MMP] and TIMP expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation MMP3 TNF 9933437 589409 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by IL-1beta and or down-regulated by IFN-gamma . Positive_regulation MMP7 ABO 20049873 2200919 Our data indicated that depressed ROS with inhibition of NADPH oxidase instead of SOD activity , stimulated NO production and eNOS activation , and *restored* [MMP] in HUVECs . Positive_regulation MMP7 ADIPOQ 24255018 2904292 mediated APPL1-AMPK signaling *induces* cell migration , [MMP] activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation MMP7 AKT1 16142341 1451294 Inhibition of signaling in LM8 by a PI3K inhibitor , LY294002 , or by a dominant negative form of Akt , *resulted* in suppression of [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Positive_regulation MMP7 AKT1 16142341 1451366 In contrast , expression of an active form of in Dunn substantially *activated* its [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Positive_regulation MMP7 AKT1 21600739 2449954 The results indicate that GlcNAc *inhibited* UVB induced collagenolytic [MMP] production by interfering with Ca ( 2+ ) -dependent and MAPKs/AP-1 and NF-?B signaling . Positive_regulation MMP7 AKT1 24276246 2955867 This hPEBP4 potentiated cell invasion and [MMP] expression is *due* to an increase in activation . Positive_regulation MMP7 AKT2 16142341 1451295 Inhibition of signaling in LM8 by a PI3K inhibitor , LY294002 , or by a dominant negative form of Akt , *resulted* in suppression of [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Positive_regulation MMP7 AKT2 16142341 1451367 In contrast , expression of an active form of in Dunn substantially *activated* its [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Positive_regulation MMP7 AKT2 21600739 2449955 The results indicate that GlcNAc *inhibited* UVB induced collagenolytic [MMP] production by interfering with Ca ( 2+ ) -dependent and MAPKs/AP-1 and NF-?B signaling . Positive_regulation MMP7 AKT2 24276246 2955868 This hPEBP4 potentiated cell invasion and [MMP] expression is *due* to an increase in activation . Positive_regulation MMP7 AKT3 16142341 1451296 Inhibition of signaling in LM8 by a PI3K inhibitor , LY294002 , or by a dominant negative form of Akt , *resulted* in suppression of [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Positive_regulation MMP7 AKT3 16142341 1451368 In contrast , expression of an active form of in Dunn substantially *activated* its [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Positive_regulation MMP7 AKT3 21600739 2449956 The results indicate that GlcNAc *inhibited* UVB induced collagenolytic [MMP] production by interfering with Ca ( 2+ ) -dependent and MAPKs/AP-1 and NF-?B signaling . Positive_regulation MMP7 AKT3 24276246 2955869 This hPEBP4 potentiated cell invasion and [MMP] expression is *due* to an increase in activation . Positive_regulation MMP7 ANG 16103692 1454172 This study tested whether *induces* [MMP] in human vascular smooth muscle cells (SMC) . Positive_regulation MMP7 ANTXR2 22529944 2589705 functions in ECM homeostasis of the murine reproductive tract and *promotes* [MMP] activity . Positive_regulation MMP7 APAF1 22226830 2550092 Altogether , we have for the first time demonstrated the critical *role* of in the regulation of MAPK , ROS , and [MMP] in UVC radiated MEFs and propose that the amplification feedback loop among mitochondrial signal molecules culminates in the demise of the cell . Positive_regulation MMP7 APC 24574263 2938431 The induction of [MMP] *activation* and cartilage degradation by was dependent on its serine protease activity . Positive_regulation MMP7 APOB 15206153 1261287 Lectin-like oxidized LDL receptor-1 ( LOX-1 ) is a cell surface receptor for oxidized LDL , which is abundantly expressed in atherosclerotic plaques and is involved in oxidized *induced* [MMP] production and apoptosis . Positive_regulation MMP7 APPL1 24255018 2904293 Adiponectin mediated signaling *induces* cell migration , [MMP] activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation MMP7 ASCL1 23300791 2712418 We now show that directly *regulates* [matrix metalloproteinase-7 (MMP-7)] and O(6)-methylguanine-DNA methyltransferase ( MGMT ) . Positive_regulation MMP7 ATF1 21505267 2448779 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or [Matrix Metalloproteinase (MMP)] . Positive_regulation MMP7 ATF2 21505267 2448780 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or [Matrix Metalloproteinase (MMP)] . Positive_regulation MMP7 ATF2 23466236 2766285 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of mitogen activated protein kinase (MAPK) , , and c-Jun , and [MMP] expression . Positive_regulation MMP7 ATF3 21505267 2448781 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or [Matrix Metalloproteinase (MMP)] . Positive_regulation MMP7 ATF4 21505267 2448782 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or [Matrix Metalloproteinase (MMP)] . Positive_regulation MMP7 ATF5 21505267 2448783 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or [Matrix Metalloproteinase (MMP)] . Positive_regulation MMP7 ATF6 21505267 2448784 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or [Matrix Metalloproteinase (MMP)] . Positive_regulation MMP7 ATF7 21505267 2448785 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the Src and 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or [Matrix Metalloproteinase (MMP)] . Positive_regulation MMP7 ATL1 19144404 2071425 Adult T-cell leukemia (ATL) is an aggressive disease characterized by visceral invasion , and *regulates* [matrix metalloproteinase (MMP)] activities of the endothelial cells . Positive_regulation MMP7 ATL2 19144404 2071426 is an aggressive disease characterized by visceral invasion , and ATL *regulates* [matrix metalloproteinase (MMP)] activities of the endothelial cells . Positive_regulation MMP7 ATL3 19144404 2071427 Adult T-cell leukemia (ATL) is an aggressive disease characterized by visceral invasion , and *regulates* [matrix metalloproteinase (MMP)] activities of the endothelial cells . Positive_regulation MMP7 ATR 12207172 983497 Thus , the *induced* [MMP] and death of cultured liver cells are both inhibited by CsA as well as by glutathione ( GSH ) and enhanced by GSH depletion . Positive_regulation MMP7 BAGE4 17156777 1694138 peptide *enhances* the expression of u-PA , u-PAR and [MMP-7] while reducing PAI-1 activity . Positive_regulation MMP7 BAX 12813466 1103231 The data reported herein indicate that LMP does not suffice to trigger caspase activation and that *dependent* [MMP] is a critical step of LMP induced cell death . Positive_regulation MMP7 BCL10 23091559 2690690 We found that dentatin mediated accumulation of reactive oxygen species ( ROS ) and downregulated expression levels of antiapoptotic molecules ( Bcl-2 , , and Survivin ) , *leading* to disruption of mitochondrial [membrane potential (MMP)] , cell membrane permeability , and release of cytochrome c from the mitochondria into the cytosol . Positive_regulation MMP7 BCL2 11067917 747149 Overexpression of *inhibited* TRAIL induced release of cytochrome c , changes in [MMP] , and apoptosis . Positive_regulation MMP7 BCL2 11960369 931603 BaxBH3Ant and *caused* a mitochondrial [membrane permeabilization (MMP)] and apoptosis , via a mechanism that was not inhibited by overexpressed Bcl-2 or Bcl-X ( L ) , yet partially inhibited by cyclosporin A ( CsA ) , an inhibitor of the mitochondrial permeability transition pore . Positive_regulation MMP7 BCL2 11960369 931625 When added to isolated mitochondria , BaxBH3 and *induced* [MMP] , which was inhibited by CsA . Positive_regulation MMP7 BCL2 11960369 931691 In purified mitochondria , two ligands of ANT , bongkrekic acid and the protein vMIA from cytomegalovirus , failed to prevent [MMP] *induced* by BaxBH3 or . Positive_regulation MMP7 BCL2 11960369 931713 In conclusion , BaxBH3 and *induce* [MMP] and apoptosis through a mechanism which overcomes cytoprotection by Bcl-2 and Bcl-X ( L ) . Positive_regulation MMP7 BCL2 15584904 1345472 Both a pseudosubstrate furin inhibitor , decanoyl-Arg-Val-Lys-Arg-chloromethylketone ( dec-RVKR-cmk ) , or alpha 1-anti-trypsin Portland ( PDX ) , a recombinant furin-inhibitory protein , suppress constitutive and *mediated* [MMP] activity and invasion . Positive_regulation MMP7 BCL2 17541305 1762467 Moreover , *induced* the expression of [MMP] in tumors grown in the orthotopic sites even though no appreciable effects were observed in the in vitro condition . Positive_regulation MMP7 BCL2 22419111 2572770 Pharmacologic inhibitors of the permeability transition pore , Bax/Bak inhibitors , and recombinant and Bcl-XL proteins do not *reduce* Tat induced [MMP] . Positive_regulation MMP7 BCL2 22491967 2613089 Second , we have highlighted that during etoposide or TNF-a treatments , intracellular ROS level , [MMP] and cell death are all *regulated* by caspases and , with caspases acting early in the process . Positive_regulation MMP7 BCL2 23091559 2690691 We found that dentatin mediated accumulation of reactive oxygen species ( ROS ) and downregulated expression levels of antiapoptotic molecules ( Bcl-2 , , and Survivin ) , *leading* to disruption of mitochondrial [membrane potential (MMP)] , cell membrane permeability , and release of cytochrome c from the mitochondria into the cytosol . Positive_regulation MMP7 BCL3 23091559 2690692 We found that dentatin mediated accumulation of reactive oxygen species ( ROS ) and downregulated expression levels of antiapoptotic molecules ( Bcl-2 , , and Survivin ) , *leading* to disruption of mitochondrial [membrane potential (MMP)] , cell membrane permeability , and release of cytochrome c from the mitochondria into the cytosol . Positive_regulation MMP7 BCL5 23091559 2690687 We found that dentatin mediated accumulation of reactive oxygen species ( ROS ) and downregulated expression levels of antiapoptotic molecules ( Bcl-2 , , and Survivin ) , *leading* to disruption of mitochondrial [membrane potential (MMP)] , cell membrane permeability , and release of cytochrome c from the mitochondria into the cytosol . Positive_regulation MMP7 BCL6 23091559 2690688 We found that dentatin mediated accumulation of reactive oxygen species ( ROS ) and downregulated expression levels of antiapoptotic molecules ( Bcl-2 , , and Survivin ) , *leading* to disruption of mitochondrial [membrane potential (MMP)] , cell membrane permeability , and release of cytochrome c from the mitochondria into the cytosol . Positive_regulation MMP7 BCL9 23091559 2690689 We found that dentatin mediated accumulation of reactive oxygen species ( ROS ) and downregulated expression levels of antiapoptotic molecules ( Bcl-2 , , and Survivin ) , *leading* to disruption of mitochondrial [membrane potential (MMP)] , cell membrane permeability , and release of cytochrome c from the mitochondria into the cytosol . Positive_regulation MMP7 BSG 11280798 798885 Purified native *induced* the production of secreted [MMP] not only by dermal fibroblasts ( MMP-1 ) but also by MDA-435 cells themselves ( MMP-2 ) , suggesting homophilic CD147 binding may occur in the context of both heterotypic and homotypic cell-cell interactions . Positive_regulation MMP7 BSG 15201341 1288976 It was shown previously that caveolin-1 associates with CD147 , thus inhibiting self-aggregation and [MMP] *induction* ; Positive_regulation MMP7 BSG 15201341 1288998 In addition , HG-CD147 ( but not LG-CD147 ) was preferentially captured as a multimer after treatment of cells with a homobifunctional cross linking agent and was exclusively recognized by monoclonal antibody AAA6 , a reagent that selectively recognizes self associated CD147 and inhibits mediated [MMP] *induction* . Positive_regulation MMP7 BSG 15319264 1303705 Additionally , oxLDLs might induce a circular upregulation of matrix degradation because , in turn , soluble *stimulates* [MMP] synthesis in HCA-SMC . Positive_regulation MMP7 BSG 15724816 1376902 *enhances* the secretion of [matrix metalloproteinases (MMP)] via cGMP/NO-sensitive capacitative calcium entry ( CCE ) and accordingly attenuates adhesion ability of fibroblasts . Positive_regulation MMP7 BSG 15781323 1385585 Later studies have shown that can also *induce* [MMP] in the same population of cells . Positive_regulation MMP7 BSG 15781323 1385607 The presence and modulation of EMMPRIN in normal tissues associated with increased MMP expression suggests that this mediated [MMP] *induction* could be a common mechanism in non-tumoral physiological and/or pathological situations . Positive_regulation MMP7 BSG 16207318 1464263 The *role* of in [MMP] production and cell invasion in vitro were studied through the co-culture of human CD14+ monocytes or monocytic line THP-1 cells and human fibroblasts , as well as by gel zymography and an invasion assay . Positive_regulation MMP7 BSG 16507143 1574182 The *role* of in [MMP] production and the cells ' invasiveness in vitro were studied by the co-culture of FLS with the human THP-1 cell line or monocytes/macrophages , by gel zymography and by invasion assay . Positive_regulation MMP7 BSG 16522689 1567965 The ability of to *stimulate* [MMP] secretion by endometrial fibroblasts indicates its potential role in uterine remodeling and the pathogenesis of endometriosis . Positive_regulation MMP7 BSG 17483329 1739055 The synergistic activities of the MCT/CD147 complex could facilitate migration of tumor cells by mediated [MMP] *induction* and lactate stimulated angiogenesis and hyaluronan production . Positive_regulation MMP7 BSG 17869266 1843041 Therefore , we tested the hypothesis that expression *regulates* [matrix metalloproteinase (MMP)] activity in rat ventricular myocytes in vitro . Positive_regulation MMP7 BSG 17869266 1843085 To determine whether expression *regulates* [matrix metalloproteinase (MMP)] activity , EMMPRIN activity was inhibited by adenoviral expression of an inhibitory mutant of EMMPRIN . Positive_regulation MMP7 BSG 17869266 1843173 The resulting increase in activity *stimulates* [MMP] expression and activity . Positive_regulation MMP7 BSG 18751374 1956307 Thus *regulates* migration , [MMP] production by SCC cells and deposition of the TN-C matrix . Positive_regulation MMP7 BSG 19003972 2016260 We have analysed the *role* of in the induction of [MMP] genes during mammary gland differentiation and involution . Positive_regulation MMP7 BSG 19003972 2016326 In summary the data argue against a causal *role* for for the induction of [MMP] gene expression during adult mammary gland development . Positive_regulation MMP7 BSG 19056510 2035466 Our studies which aimed to explore mechanisms of matrix degradation in pathological corneal wound healing have shown that , a glycoprotein expressed on corneal epithelial cell surface , can *induce* [matrix metalloproteinase (MMP)] production and myofibroblasts differentiation after direct interaction with corneal fibroblasts . Positive_regulation MMP7 BSG 20648565 2363099 In view of the [MMP] *inducing* function of , its role in myogenic cell differentiation was investigated . Positive_regulation MMP7 BSG 21536654 2440162 Overexpression of *inhibited* HCC cell proliferation , [MMP] induction , and cell invasion in vitro and in vivo . Positive_regulation MMP7 BSG 21637915 2450925 is a glycosylated transmembrane protein containing two immunoglobulin ( Ig ) domains that is expressed in carcinoma cells and *stimulates* [MMP] production by adjacent stromal cells . Positive_regulation MMP7 BSG 23005037 2716327 Moreover , native glycosylated existed exclusively as oligomers in solution and directly *stimulated* [MMP] production more efficiently than non glycosylated prokaryotic CD147 . Positive_regulation MMP7 BTRC 14981939 1182841 did not *enhance* [MMP] activity in any of the cell lines tested . Positive_regulation MMP7 C5 23287562 2769296 *increased* the release of [matrix metalloproteinases (MMP)] from cancer cells by two- to 11-fold , and inhibition of MMP activity abolished the C5a enhancing effect on cancer cell invasion . Positive_regulation MMP7 CAD 22127696 2514932 stimulation *increased* RA synovial fibroblast [MMP] messenger RNA levels . Positive_regulation MMP7 CALML3 12909586 1157501 In conclusion , exposing TIMP-3 null animals to sepsis rapidly enhances the phenotypic abnormalities of these mice , due to increased [MMP] activity *induced* by . Positive_regulation MMP7 CAPN1 21911754 2497110 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP7 CAPN1 21964156 2525888 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP7 CAPN1 22316244 2553394 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP7 CAPN10 21911754 2497111 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP7 CAPN10 21964156 2525889 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP7 CAPN10 22316244 2553395 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP7 CAPN11 21911754 2497112 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP7 CAPN11 21964156 2525890 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP7 CAPN11 22316244 2553396 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP7 CAPN12 21911754 2497109 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP7 CAPN12 21964156 2525887 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP7 CAPN12 22316244 2553393 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP7 CAPN13 21911754 2497120 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP7 CAPN13 21964156 2525898 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP7 CAPN13 22316244 2553404 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP7 CAPN14 21911754 2497121 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP7 CAPN14 21964156 2525899 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP7 CAPN14 22316244 2553405 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP7 CAPN15 21911754 2497108 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP7 CAPN15 21964156 2525886 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP7 CAPN15 22316244 2553392 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP7 CAPN2 21911754 2497113 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP7 CAPN2 21964156 2525891 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP7 CAPN2 22316244 2553397 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP7 CAPN3 21911754 2497114 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP7 CAPN3 21964156 2525892 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP7 CAPN3 22316244 2553398 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP7 CAPN5 21911754 2497115 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP7 CAPN5 21964156 2525893 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP7 CAPN5 22316244 2553399 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP7 CAPN6 21911754 2497116 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP7 CAPN6 21964156 2525894 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP7 CAPN6 22316244 2553400 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP7 CAPN7 21911754 2497117 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP7 CAPN7 21964156 2525895 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP7 CAPN7 22316244 2553401 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP7 CAPN8 21911754 2497118 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP7 CAPN8 21964156 2525896 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP7 CAPN8 22316244 2553402 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP7 CAPN9 21911754 2497119 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP7 CAPN9 21964156 2525897 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP7 CAPN9 22316244 2553403 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP7 CARM1 18511550 1951917 Furthermore , we show that also *regulates* [MMP] expression at the post-transcriptional level , either positively or negatively . Positive_regulation MMP7 CASP1 11067917 747400 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP7 CASP1 19593672 2224380 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP7 CASP10 11067917 747401 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP7 CASP10 19593672 2224381 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP7 CASP12 11067917 747411 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP7 CASP12 19593672 2224391 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP7 CASP14 11067917 747402 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP7 CASP14 19593672 2224382 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP7 CASP16 11067917 747412 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP7 CASP16 19593672 2224392 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP7 CASP2 11067917 747403 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP7 CASP2 19593672 2224383 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP7 CASP3 11067917 747404 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP7 CASP3 12750841 1107435 As ( 2 ) O ( 3 ) induced apoptosis in parent MOLT-4 cells and MOLT-4/DNR cells expressing functional P-gp via depletion of intracellular GSH , and subsequent disruption of [MMP] and *activation* of . Positive_regulation MMP7 CASP3 16877372 1625551 Using cell culture assay model , we revealed in our results that ginkgolide B treatment of ESCs ( ESC-B5 ) induced apoptosis via reactive oxygen species ( ROS ) generation , c-Jun N-terminal kinase (JNK) activation , loss of mitochondrial [membrane potential (MMP)] and the *activation* of . Positive_regulation MMP7 CASP3 17331071 1733828 Experiments in embryonic stem cells ( ESC-B5 ) showed that CTN induces apoptosis via ROS ( reactive oxygen species ) generation , increased Bax/Bcl-2 ratio , loss of [MMP] ( mitochondrial membrane potential ) , induction of cytochrome c release , and *activation* of . Positive_regulation MMP7 CASP3 17573851 1903041 Apoptosis signalling was monitored by assessment of EPS , disruption of [MMP] and *activation* of by flow cytometry . Positive_regulation MMP7 CASP3 18313257 1978967 The sulforaphane induced apoptosis in U937 cells correlated with the generation of intracellular ROS , collapse of [MMP] , *activation* of , and down-regulation of anti-apoptotic Bcl-2 expression . Positive_regulation MMP7 CASP3 18804340 2028425 However , the quenching of ROS generation in response to treatment with a ROS scavenger , N-acetyl-L-cysteine , reversed the platycodon D-induced apoptosis effects via inhibition of Egr-1 activation , ROS production , [MMP] collapse , and the subsequent *activation* of . Positive_regulation MMP7 CASP3 19047834 1999222 The results of this study demonstrated that streptochlorin mediates ROS production , and that this mediation is followed by a decrease in the mitochondrial membrane potential ( [MMP] , m ) , *activation* of , and downregulation of antiapoptotic Bcl-2 protein . Positive_regulation MMP7 CASP3 19047834 1999245 The quenching of ROS generation by N-acetyl-L-cysteine administration , a scavenger of ROS , reversed the streptochlorin induced apoptosis effects via inhibition of ROS production , [MMP] collapse , and the subsequent *activation* of . Positive_regulation MMP7 CASP3 19259823 2072682 Significant enhancement of Fas externalization , loss of mitochondrial [membrane potential (MMP)] , and *activation* of and caspase-8 were observed after the combined treatment . Positive_regulation MMP7 CASP3 19593672 2224384 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP7 CASP3 19736292 2152756 Pre-treatment with broad-spectrum caspase inhibitor Z-VAD-FMK , inhibitor Ac-DEVD-CHO and caspase-8 inhibitor Z-IETD-FMK *prevented* the change in [MMP] and DNA fragmentation , suggesting caspase dependent apoptosis of rYopJ treated macrophages . Positive_regulation MMP7 CASP3 19944168 2198921 At 8 h and 12 h p.i. , IPNV infected cells demonstrated a dramatic increase in [MMP] loss , rapid entry into necrotic cell death , and *activation* of . Positive_regulation MMP7 CASP3 20111678 2178729 In the present study , we examined the effects of resveratrol on apoptotic biochemical events in Hep G2 cells induced by CTN. Resveratrol inhibited CTN induced ROS generation , activation of JNK , loss of mitochondrial [membrane potential (MMP)] , as well as *activation* of caspase-9 , and PAK2 . Positive_regulation MMP7 CASP3 20147844 2242438 Separate in vitro studies demonstrated that activated caspase species cleaved pro-MMP-2 yielding active MMP-2 forms and that [MMP] activity was increased in the *presence* of activated . Positive_regulation MMP7 CASP3 21334318 2415215 Cafestol induced apoptosis is associated with the reduction of mitochondrial [membrane potential (MMP)] , *activation* of , cytochrome c release , and down-regulation of anti-apoptotic proteins ( Bcl-2 , Bcl-xL , Mcl-1 and cFLIP ) . Positive_regulation MMP7 CASP3 21595920 2445685 Curcumin induced apoptosis was associated with reduced expression of both Bcl-2 mRNA and protein , subsequent loss of [MMP] , and *activation* of followed by PARP degradation . Positive_regulation MMP7 CASP3 21656837 2532072 Furthermore , increase of ROS , loss of [MMP] , *activation* of , and down-regulation of Bcl-2 expression was observed . Positive_regulation MMP7 CASP3 21723035 2461060 TMEM14A prevented 4-HPR induced loss of mitochondrial [membrane potential (MMP)] , the release of cytochrome c , and the *activation* of , but not the generation of reactive oxygen species , suggesting that TMEM14A regulates mitochondrial membrane potential in a ROS independent manner . Positive_regulation MMP7 CASP3 21793156 2803077 Further investigation of these processes revealed that MG directly promotes reactive oxygen species ( ROS ) generation , loss of mitochondrial [membrane potential (MMP)] , and *activation* of , whereas resveratrol effectively blocks MG-induced ROS production and the accompanying apoptotic biochemical changes . Positive_regulation MMP7 CASP3 21865727 2473469 The apoptosis of AML cells after 4-AP treatment was further confirmed by the disruption of mitochondrial [membrane potential (MMP)] and *activation* of and 9 . Positive_regulation MMP7 CASP3 22449440 2582997 Furthermore , the overexpression of Bcl-xL significantly prevented FRAP induced apoptosis , [MMP] changes , and the *activations* of , -8 , and -9 . Positive_regulation MMP7 CASP3 23660334 2796024 Sanguinarine generated ROS , which was followed by a decrease in the mitochondrial [membrane potential (MMP)] , the *activation* of , and the down-regulation of anti-apoptotic proteins , such as Bcl2 , XIAP and cIAP-1 . Positive_regulation MMP7 CASP3 24098753 2852346 Furthermore , our results revealed that induction of apoptosis through a mitochondrial pathway led to up-regulation of pro-apoptotic protein expression ( Bax ) , down-regulation of anti-apoptotic protein expression ( Bcl-2 ) , mitochondrial release of cytochrome c (Cyto c) , reduction of mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP7 CASP3 24335836 2895086 Consistently , bornyl caffeate increased Bax and decreased Bcl-xl , resulting in the disruption of [MMP] and subsequent *activation* of . Positive_regulation MMP7 CASP4 11067917 747405 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP7 CASP4 19593672 2224385 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP7 CASP5 11067917 747406 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP7 CASP5 19593672 2224386 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP7 CASP6 11067917 747407 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP7 CASP6 19593672 2224387 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP7 CASP7 11067917 747408 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP7 CASP7 19593672 2224388 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP7 CASP8 11067917 747409 The pan caspase inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) blocked changes in MMP and apoptosis , suggesting that the changes in [MMP] were *dependent* on activation of . Positive_regulation MMP7 CASP8 19259823 2072683 Significant enhancement of Fas externalization , loss of mitochondrial [membrane potential (MMP)] , and *activation* of caspase-3 and were observed after the combined treatment . Positive_regulation MMP7 CASP8 19593672 2224389 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP7 CASP9 11067917 747410 The pan inhibitor z-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ) and the inhibitor of caspase-8 ( z-Ile-Glu-Thr-Asp-fluoromethylketone ; zIETD-fmk ) *blocked* changes in [MMP] and apoptosis , suggesting that the changes in MMP were dependent on activation of caspase-8 . Positive_regulation MMP7 CASP9 15557813 1340945 We also observed ceramide/ DMS induced disruption of mitochondrial [membrane potential (MMP)] and *activation* of and -3 in a radiation-dose dependent manner . Positive_regulation MMP7 CASP9 19593672 2224390 Then , we demonstrated that the treatment of ConA caused mitochondrial transmembrane potential ( [MMP] ) collapse , cytochrome c release , and *activation* of . Positive_regulation MMP7 CASP9 19944168 2198922 At 8 h and 12 h p.i. , IPNV infected cells demonstrated a dramatic increase in [MMP] loss , rapid entry into necrotic cell death , and *activation* of and -3 . Positive_regulation MMP7 CASP9 23660334 2796025 Sanguinarine generated ROS , which was followed by a decrease in the mitochondrial [membrane potential (MMP)] , the *activation* of and -3 , and the down-regulation of anti-apoptotic proteins , such as Bcl2 , XIAP and cIAP-1 . Positive_regulation MMP7 CAT 23352441 2747594 Phagocytosis , the loss of [MMP] , autophagy and the activated signaling pathways were all *suppressed* by ROS scavenger N-acetyl-l-cysteine (NAC) , H2O2 scavenger or OH scavenger glutathione ( GSH ) . Positive_regulation MMP7 CCDC88A 23568586 2810261 Pretreatment with doxycycline blunted *induced* increases in RV myocardial ROS concentrations and [MMP] gelatinolytic activity ( both P < 0.05 ) . Positive_regulation MMP7 CCL19 17170367 1694885 and CCL21 promoted an inflammatory phenotype in T-cells and macrophages and *increased* [matrix metalloproteinase (MMP)] and tissue factor levels in the latter cell type . Positive_regulation MMP7 CCL21 17170367 1694886 CCL19 and promoted an inflammatory phenotype in T-cells and macrophages and *increased* [matrix metalloproteinase (MMP)] and tissue factor levels in the latter cell type . Positive_regulation MMP7 CD151 17009258 1634050 Tetraspanin is expressed in osteoarthritic cartilage and is *involved* in pericellular activation of [pro-matrix metalloproteinase 7] in osteoarthritic chondrocytes . Positive_regulation MMP7 CD40 15290728 1278606 interaction *augments* the expression of inflammatory cytokines and [MMP] in chondrocytes and contributes to an intrinsic process of cartilage degradation in RA . Positive_regulation MMP7 CD40 17949416 1894432 Finally , we investigated whether ligand (CD40L) interactions were *involved* in T-cell stimulated [MMP] secretion from macrophages . Positive_regulation MMP7 CD40LG 15290728 1278607 interaction *augments* the expression of inflammatory cytokines and [MMP] in chondrocytes and contributes to an intrinsic process of cartilage degradation in RA . Positive_regulation MMP7 CD40LG 9933437 589366 Therefore , we analysed the *induced* [MMP] production by these fibroblasts in the presence of cytokines that are increased in periodontal lesions , such as IL-1beta , tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) . Positive_regulation MMP7 CDC73 23911909 2840389 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Positive_regulation MMP7 CDH1 11640889 871977 Integrin- and *mediated* induction of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDH10 11640889 871978 Integrin- and mediated *induction* of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDH11 11640889 871979 Integrin- and *mediated* induction of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDH11 22127696 2514842 The objective of this study was to determine if synovial fibroblast [MMP] production is *regulated* by . Positive_regulation MMP7 CDH11 22127696 2514954 These results underscore the existence of a pathway by which *regulates* [MMP] production and has important implications for joint destruction in RA . Positive_regulation MMP7 CDH12 11640889 871980 Integrin- and mediated *induction* of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDH13 11640889 871981 Integrin- and *mediated* induction of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDH15 11640889 871982 Integrin- and mediated *induction* of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDH16 11640889 871983 Integrin- and *mediated* induction of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDH17 11640889 871984 Integrin- and mediated *induction* of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDH18 11640889 871985 Integrin- and *mediated* induction of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDH19 11640889 871986 Integrin- and mediated *induction* of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDH2 11640889 871987 Integrin- and *mediated* induction of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDH20 11640889 871988 Integrin- and mediated *induction* of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDH22 11640889 871973 Integrin- and *mediated* induction of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDH23 11640889 871974 Integrin- and mediated *induction* of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDH24 11640889 871975 Integrin- and *mediated* induction of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDH26 11640889 871976 Integrin- and mediated *induction* of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDH3 11640889 871989 Integrin- and *mediated* induction of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDH4 11640889 871990 Integrin- and mediated *induction* of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDH5 11640889 871991 Integrin- and *mediated* induction of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDH6 11640889 871992 Integrin- and mediated *induction* of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDH7 11640889 871993 Integrin- and *mediated* induction of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDH8 11640889 871994 Integrin- and mediated *induction* of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDH9 11640889 871995 Integrin- and *mediated* induction of the matrix metalloprotease [matrilysin] in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts . Positive_regulation MMP7 CDK2 21822799 2463011 Ectopic expression of the dominant negative ( Cdk2-dn ) and a specific Cdk2 inhibitor , p21 ( WAF1/CIP1 ) , effectively *suppresses* the loss of [MMP] , the release of cytochrome c , and subsequent activation of caspase-3 in paclitaxel treated cells . Positive_regulation MMP7 CHMP2A 11960369 931669 However , Bcl-2 or Bcl-X ( L ) failed to inhibit [MMP] *induced* by BaxBH3 and in vitro , while they efficiently suppressed the induction of MMP by the Vpr protein ( from human immunodeficiency virus-1 ) , a ligand of the adenine nucleotide translocator ( ANT ) . Positive_regulation MMP7 CITED2 12960175 1164259 Using the immortalized human chondrocyte cell line , C-28/I2 , we investigated whether CITED2 could be responsive to mechanical stimuli , and if so , whether could *mediate* shear-driven regulation of [matrix metalloproteinase (MMP)] genes . Positive_regulation MMP7 COL1A1 16004981 1452929 Since previous studies have demonstrated that interaction of interstitial fibroblasts with high molecular weight fragments of *leads* to increased [MMP] production , the present results suggest a mechanism underlying altered function of stromal elements in the connective tissue adjacent to the growing neoplasm . Positive_regulation MMP7 COL1A2 16004981 1452930 Since previous studies have demonstrated that interaction of interstitial fibroblasts with high molecular weight fragments of *leads* to increased [MMP] production , the present results suggest a mechanism underlying altered function of stromal elements in the connective tissue adjacent to the growing neoplasm . Positive_regulation MMP7 CPOX 20654727 2340584 The inhibitors of and/or LOX could *inhibit* cell proliferation , [MMP] activity and invasion in head and neck and colon cancer cells . Positive_regulation MMP7 CRIP1 17676380 1805388 Levels of [matrix metalloproteinase-7] , reversion *inducing* with Kazal motifs , chemokine receptor 7 , and vascular endothelial growth factor-C messenger RNA in both the invasive front and inner surface of colorectal cancer tumors were measured by using real-time quantitative reverse transcriptase-polymerase chain reaction . Positive_regulation MMP7 CRIP2 17676380 1805389 Levels of [matrix metalloproteinase-7] , reversion *inducing* with Kazal motifs , chemokine receptor 7 , and vascular endothelial growth factor-C messenger RNA in both the invasive front and inner surface of colorectal cancer tumors were measured by using real-time quantitative reverse transcriptase-polymerase chain reaction . Positive_regulation MMP7 CRIP3 17676380 1805387 Levels of [matrix metalloproteinase-7] , reversion *inducing* with Kazal motifs , chemokine receptor 7 , and vascular endothelial growth factor-C messenger RNA in both the invasive front and inner surface of colorectal cancer tumors were measured by using real-time quantitative reverse transcriptase-polymerase chain reaction . Positive_regulation MMP7 CRP 16580524 1543687 stimulation also *increased* MMP-1 and -10 protein in conditioned culture medium ( p < 0.001 ) , as well as [MMP] activity ( p = 0.001 ) . Positive_regulation MMP7 CSE 15096214 1238786 VIP , at 10 ( -7 ) m , reduced *stimulated* [MMP] activity and caspase-3 activation . Positive_regulation MMP7 CSF2 15363038 1293909 *activates* RhoA , integrin and [MMP] expression in human monocytic cells . Positive_regulation MMP7 CSF2 18252806 1895830 TNF-alpha *induces* the expression of transcripts for inflammatory mediators interleukin (IL)-6 , IL-8 , regulated on activation normal T cell expressed and secreted , TNF-alpha , granulocyte ( GM-CSF ) , and monocyte chemoattractant protein (MCP)-1 and also invasion mediators [matrix metalloproteinase (MMP)-7] , MMP-9 , and intracellular adhesion molecule-1 . Positive_regulation MMP7 CSF2 9610697 508818 also *increased* the [MMP] activity of LK-2 and LC-1 cells . Positive_regulation MMP7 CSRP1 18245817 1890647 *promotes* OxLDL uptake and [MMP] induction in vitro ; Positive_regulation MMP7 CTGF 18632843 1979324 In conclusion , upregulation of inhibits BMP-7 signal transduction in the diabetic kidney and *contributes* to altered gene transcription , reduced [MMP] activity , glomerular basement membrane thickening , and albuminuria , all of which are hallmarks of diabetic nephropathy . Positive_regulation MMP7 CTNNB1 10362259 619967 Inactivation of the Tcf binding site increased promoter activity and overexpression of the Tcf factor , LEF-1 , significantly downregulated matrilysin promoter activity , suggesting that *transactivates* the [matrilysin] promoter by virtue of its ability to abrogate Tcf mediated repression . Positive_regulation MMP7 CTNNB1 10514384 651560 *regulates* the expression of the [matrix metalloproteinase-7] in human colorectal cancer . Positive_regulation MMP7 CTNNB1 12498294 1026311 Nuclear *enhances* the activating expression of [MMP-7] genes by binding with the T-cell factor/lymphoid enhancer factor family of transcription factors . Positive_regulation MMP7 CTNNB1 15313922 1285768 Because can *regulate* [MMP] expression , we investigated the expression of several MMPs and TIMPs in aggressive fibromatosis tumors that develop in Apc+/Apc1638N mice . Positive_regulation MMP7 CTNNB1 15760903 1403566 expression markedly *increased* expression of MMP-2 , MMP-3 , [MMP-7] , MMP-9 , MT3-MMP , and ADAMTS5 . Positive_regulation MMP7 CTNNB1 15817151 1393349 More importantly , Kaiso blocked *mediated* activation of the [matrilysin] promoter . Positive_regulation MMP7 CTNNB1 20677010 2311825 Here , we report that hepatocyte growth factor (HGF) induced E-cadherin downregulation and cell scattering are attributed to the activation of signaling and transcriptional *activation* of matrix metalloproteinase [MMP-7] . Positive_regulation MMP7 CTNNB1 22739727 2621732 siRNA mediated down-regulation of elevated the E-cadherin expression but *reduced* the [MMP-7] and CD44v6 expressions , which increased the adhesion between LoVo cells but decreased the adhesion of LoVo cells to fibronectin . Positive_regulation MMP7 CTR9 23911909 2840390 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Positive_regulation MMP7 CUL1 14981939 1182842 did not *enhance* [MMP] activity in any of the cell lines tested . Positive_regulation MMP7 DCT 17222808 1703647 *stimulated* a greater than 10-fold increase in [MMP-7] gene transcription . Positive_regulation MMP7 DDC 16638095 1552891 *activated* PSC , increasing the number of alpha-SMA positive cells , enhancing secretion of type I collagen and [MMP] , inhibiting PSC proliferation . Positive_regulation MMP7 DEFA1 21896310 2487007 The results showed that adenosine triphosphate ( ATP ) and mitochondrial [membrane potential (MMP)] in the astrocytes were up-regulated in the presence of ADP , which could be *enhanced* by , a specific antagonist for P2Y(1) receptor . Positive_regulation MMP7 DFFB 22127696 2514888 This up-regulation required cell cadherin 11 engagement , since a mutant with reduced binding affinity *stimulated* significantly less [MMP] production . Positive_regulation MMP7 DFFB 22127696 2514910 Also , short hairpin RNA ( shRNA ) cadherin 11 silencing almost completely inhibited *induced* [MMP] expression . Positive_regulation MMP7 EDN1 12842810 1149610 Thus early changes in *mediated* regulation of [MMP] activity were measured in borderline hypertensive rats that develop impaired vasorelaxation and hypertension with chronic exposure to stress . Positive_regulation MMP7 EDN1 12875994 1115294 Combined addition of both ET ( B ) receptor ( ET ( B ) R ) and ET ( A ) R antagonists completely blocked the *induced* [MMP] activity . Positive_regulation MMP7 EDN1 14558091 1153694 Recently , it was suggested that , a potent vasoconstrictor , may be *involved* in [MMP] regulation . Positive_regulation MMP7 EDNRA 12842810 1149544 Recent studies demonstrated that receptors *regulate* cardiac [MMP] activity and fibrosis in DOCA-salt hypertension . Positive_regulation MMP7 EGF 10398277 627898 *induces* the expression of [matrilysin] in the human prostate adenocarcinoma cell line , LNCaP . Positive_regulation MMP7 EGF 10398277 627918 *Induction* of the [MMP] , matrilysin , by was investigated in a human prostate cancer cell line . Positive_regulation MMP7 EGF 12851697 1109654 These results suggest that plays also an important *role* in [MMP-7] production of TE-9 cells and that there is a difference not only in EGF-intracellular signaling system but also in regulation mechanisms of MMP-7 transcription by beta-catenin-Tcf and/or PEA3 system between these 2 carcinoma lines . Positive_regulation MMP7 EGF 15138601 1246885 *upregulates* [matrix metalloproteinase-7] expression through activation of PEA3 transcription factors . Positive_regulation MMP7 EGF 15138601 1246886 We were therefore interested in addressing the question of whether [MMP-7] could be *regulated* by and in identifying the molecular mechanisms through which this process occurs . Positive_regulation MMP7 EGF 15138601 1246888 Herein , we have demonstrated that *enhanced* the endogenous expression of [MMP-7] in a number of human colon cancer cell lines . Positive_regulation MMP7 EGF 15138601 1246900 These data demonstrate for the first time that directly *enhances* [MMP-7] expression via the activation of PEA3 transcription factors . Positive_regulation MMP7 EGF 15780084 1385279 These responses which are dependent on its protease activity appear not to be mediated by PAR-1 activation , the autocrine action of thrombin induced TGF-beta1 secretion , [MMP] activation , or receptor *transactivation* . Positive_regulation MMP7 EGF 16394028 1554008 EGF withdrawal resulted in a more epithelial morphology and reversal of the *induced* activation of signaling pathways and [pro-MMP] activity . Positive_regulation MMP7 EGF 24744893 2936382 Here , we examined the role of *mediated* [matrix metalloproteinases (MMP)] on the stability of interstitial collagens in vascular smooth muscle cells ( VSMCs ) isolated from carotid endarterectomy tissues of symptomatic and asymptomatic patients with carotid stenosis . Positive_regulation MMP7 EGFR 12421825 1036469 Targeting of only the E domain of ERalpha to the plasma membrane resulted in [MMP] activation and *transactivation* . Positive_regulation MMP7 EGFR 16289596 1546869 In these experiments we used an inhibitor , AG1478 or [matrix metalloproteinase (MMP)] *inhibitor* , GM6001 . Positive_regulation MMP7 EGFR 17348021 1748220 Here we provide genetic and biochemical evidence that and AP-1 mediated signals are *required* for [MMP] expression and collagen contraction in fibroblasts . Positive_regulation MMP7 EGFR 20889674 2353458 To explore the EGFR signaling pathway , we used a broad-spectrum [matrix metalloproteinase (MMP)] *inhibitor* , GM-6001 , two selective tyrosine kinase inhibitors , AG-1478 and PD-153035 , an HB-EGF neutralizing antibody , and a specific small interfering RNA ( siRNA ) against the EGFR . Positive_regulation MMP7 EGFR 23644655 2926286 We demonstrated that macrophages stimulate cancer cell invasion , motility and migration , and that these effects depend on [matrix metalloproteinase (MMP)] activity and on the *activation* of ( at the residue Y ( 1086 ) ) , PLC-? ( phospholipase C-gamma ) and Gab1 ( GRB2 associated binding protein-1 ) , as evidenced by siRNA ( small interference RNA ) experiments . Positive_regulation MMP7 EPHB2 14709335 1196664 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP7 EPHB2 20843518 2353073 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and *dependent* [MMP] expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation MMP7 EPHB2 24012928 2862360 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an [MMP] *inhibitor* , or PD98059 ( 50 µM ) , an inhibitor , also suppressed it . Positive_regulation MMP7 EPX 21461559 2412801 Specifically , we studied whether combined with G-CSF *enhanced* [MMP] expression and increased the in vitro motility of MSCs . Positive_regulation MMP7 ERBB2 18411043 1907778 *dependent* [MMP-7] expression is mediated by activated STAT3 . Positive_regulation MMP7 ERBB2 18600430 1972312 Our data suggest that HRG-beta induced [MMP-7] expression was *regulated* by mediated AP-1 activation in MCF-7 cells . Positive_regulation MMP7 ERVK-6 11451908 836799 Furthermore , in models of airway injury , [matrilysin] expression is upregulated in migrating epithelial cells , and the activity of this is *required* for repair of airway wounds . Positive_regulation MMP7 ERVK-6 16772705 1572839 In addition , the proteolytic activity was almost completely inhibited by BS-10 , a [MMP] *inhibitor* , but not by the serine proteinase inhibitors , cysteine inhibitors and aspartic proteinase inhibitors . Positive_regulation MMP7 ERVK-6 8698831 375337 These results suggested that during ischemic cardiomyopathy , initially neutrophil *activates* latent myocardial [MMP] which can degrade ECM , which continuously degrades if not controlled by TIMP , leading to ventricular dilatation and dysfunction . Positive_regulation MMP7 ETS1 18181172 1889994 Moreover , concomitantly *triggered* [matrix metalloproteinases (MMP)] expression and activation , thus contributing to cell scattering . Positive_regulation MMP7 ETV1 23076342 2716936 *regulates* [matrix metalloproteinase-7] transcription in LNCaP prostate cancer cells . Positive_regulation MMP7 ETV4 10836994 698077 We have previously reported that the Ets-oncogene family transcription factor positively *regulates* transcription of [MMP] genes in transient expression assays and that overexpression of the E1AF gene confers an invasive phenotype on breast cancer cells . Positive_regulation MMP7 ETV4 9197532 438584 The ets transcription factor can *activate* several [matrix degrading metalloproteinase (MMP)] genes and is implicated in enhancement of tumor cell invasion . Positive_regulation MMP7 F7 22076613 2568000 Tissue factor/activated *induces* [matrix metalloproteinase-7] expression through activation of c-Fos via ERK1/2 and p38 MAPK signaling pathways in human colon cancer cell . Positive_regulation MMP7 FABP3 22528395 2602395 The results revealed that downregulated expression promoted apoptosis , and resulted in mitochondrial deformation , *increased* mitochondrial [membrane potential (MMP)] , and decreased intracellular ATP synthesis . Positive_regulation MMP7 FGF1 11922392 926428 Transient transfection with dominant negative STAT3 inhibited *induced* transactivation of the [matrilysin] promoter indicating that STAT3 plays an important role in FGF1 induced matrilysin expression . Positive_regulation MMP7 FGF2 16494848 1528732 We show that the angiogenic factor *induces* [MMP7] expression in human endothelial cells . Positive_regulation MMP7 FGF2 16494848 1528733 The promoter contains a Lef/Tcf consensus sequence , but using wildtype or Lef/Tcf mutated promoter constructs , *induced* [MMP7] reporter activity is independent from Lef/Tcf sites . Positive_regulation MMP7 FGF2 16494848 1528735 Instead , we show that overexpression of a dominant negative Stat3 mutant reduces *mediated* [MMP7] promoter activity . Positive_regulation MMP7 FGF2 16494848 1528738 This is confirmed by MMP7 promoter constructs with mutated AP-1 sites which did not respond to FGF-2 and by siRNAs against Stat1 and Stat3 , which repressed *induced* [MMP7] protein expression . Positive_regulation MMP7 FGF2 16494848 1528739 In conclusion , we show that *induced* [MMP7] expression in endothelium depends on AP-1 and FGF-2 signaling to AP-1 involves a Stat1/3 dependent pathway . Positive_regulation MMP7 FGF2 9858899 555726 The CAPL protein expressed in cell-cultures appear to block the [MMP] *induction* by and Il-1 alpha . Positive_regulation MMP7 FLT1 9776730 540200 These data suggest the *role* of in mediating VEGF stimulated [MMP] expression of SMCs . Positive_regulation MMP7 FN1 11134254 769474 In addition , [MT-MMP] activity , selectively *induced* by , was implicated in the activation of the secreted proteinases . Positive_regulation MMP7 FN1 16788844 1577636 In this present communication , we cultured human cervical cancer cells , SiHa , in the presence of fibronectin to study *mediated* modulation of [MMP] activity . Positive_regulation MMP7 FN1 17341207 1665010 In this present study , we cultured human fibrosarcoma cells , HT-1080 , in presence of fibronectin to study *mediated* modulation of [MMP] activity . Positive_regulation MMP7 FN1 18243246 1871521 Blocking of alpha5beta 1 integrin with anti-alpha5 monoclonal antibody inhibits the *induced* [MMP] activation response appreciably . Positive_regulation MMP7 FN1 18396067 1958063 To define the role of mitogen activated protein ( MAP ) kinases in *mediated* [matrix metalloproteinase (MMP)] upregulation and damage to bovine cartilage and to compare activities of three Fn-fs with native fibronectin (Fn) , which is inactive in terms of cartilage damage . Positive_regulation MMP7 FN1 18540849 1923484 In this present work , we cultured human A375 melanoma cells in the presence of fibronectin to study *mediated* modulation of [MMP] activity . Positive_regulation MMP7 FN1 20224727 2223610 In the present communication we cultured K562 cells in *presence* of to study the fibronectin-integrin mediated signalling and modulation of [MMP] expression . Positive_regulation MMP7 FNTA 10811109 692947 Similarly , a Ras inhibitor , manumycin A , and a MEK1 inhibitor , U0126 , *suppressed* [MMP] secretion in a dose dependent manner , whereas a PI3 kinase inhibitor , wortmannin , could not . Positive_regulation MMP7 FNTB 10811109 692948 Similarly , a Ras inhibitor , manumycin A , and a MEK1 inhibitor , U0126 , *suppressed* [MMP] secretion in a dose dependent manner , whereas a PI3 kinase inhibitor , wortmannin , could not . Positive_regulation MMP7 FURIN 15584904 1345471 Both a pseudosubstrate inhibitor , decanoyl-Arg-Val-Lys-Arg-chloromethylketone ( dec-RVKR-cmk ) , or alpha 1-anti-trypsin Portland ( PDX ) , a recombinant furin-inhibitory protein , *suppress* constitutive and BCL-2 mediated [MMP] activity and invasion . Positive_regulation MMP7 FURIN 18392131 1893505 Here , we show that this cell-permeable , small-molecule compound inhibits *mediated* cleavage of [proMT1-MMP] , resulting in decreased MMP-2 activation and cell motility in CHO cells expressing proMT1-MMP . Positive_regulation MMP7 GAB1 23644655 2926287 We demonstrated that macrophages stimulate cancer cell invasion , motility and migration , and that these effects depend on [matrix metalloproteinase (MMP)] activity and on the *activation* of epidermal growth factor receptor (EGFR) ( at the residue Y ( 1086 ) ) , PLC-? ( phospholipase C-gamma ) and ( GRB2 associated binding protein-1 ) , as evidenced by siRNA ( small interference RNA ) experiments . Positive_regulation MMP7 GIT1 19023093 2022676 Therefore , *mediates* VEGF induced [matrix metalloproteinase (MMP)] activation and ECM degradation by regulating podosome formation . Positive_regulation MMP7 GLRX 18560520 1924113 Our studies demonstrate that , a cytosolic oxido-reductase , helps maintain mitochondrial integrity and *prevents* [MMP] loss caused by oxidative insult . Positive_regulation MMP7 GNRH1 17108127 1645188 Knockdown of the GnRH receptor using small interfering RNA significantly inhibited the *induced* [MMP] activation , invasion , and migration . Positive_regulation MMP7 GNRH1 17108127 1645458 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 mitogen activated protein kinase , signaling pathway was critical for *mediated* up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP7 GPR65 23707809 2801547 The *induction* of [MMP] expression by was further confirmed in A549 and/or FaDu cells . Positive_regulation MMP7 GPR65 23707809 2801569 *mediated* [MMP] induction under acidic conditions . Positive_regulation MMP7 HDAC1 12810630 1102801 In this study , we test the possibility that inhibitor may increase RECK expression to *inhibit* [MMP] activation and cancer cell invasion . Positive_regulation MMP7 HDAC2 12810630 1102802 In this study , we test the possibility that inhibitor may increase RECK expression to *inhibit* [MMP] activation and cancer cell invasion . Positive_regulation MMP7 HDAC4 20847282 2325741 Furthermore , ectopic expression of in quiescent HSCs *results* in repression of [MMP] promoter activities as well as endogenous MMP9 protein expression . Positive_regulation MMP7 HGF 10860849 704968 *enhances* [MMP] activity in human endothelial cells . Positive_regulation MMP7 HGF 12606436 1064592 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by tumor necrosis factor alpha (TNFalpha) , IL-6 , , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP7 HGF 16998831 1640855 Conversely , the elevated cancer invasion , [MMP] activity and c-Met phosphorylation of PK8 cells were *reduced* by the removal of from hypoxic conditioned medium . Positive_regulation MMP7 HGF 21292466 2489327 *promoted* cell proliferation , migration , invasion and induction of [MMP] ( matrix metalloproteinase)-2 and MMP-9 in KB cells . Positive_regulation MMP7 HGF 9759374 536360 After 24 or 48 h of culture in medium supplemented with HGF , transforming growth factor-alpha ( TGF-alpha ) or sodium butyrate , [MMP] production by DHD/K12 cells was *stimulated* by and TGF-alpha and inhibited by sodium butyrate . Positive_regulation MMP7 HMGB1 21871094 2510339 in complex with IL-1ß *increased* [MMP] production from both RASF and OASF . Positive_regulation MMP7 HNRNPU 18653469 1967107 H. pylori increases [mmp-7] mRNA levels in a cag- and p120 dependent manner and *induces* translocation of to the nucleus in vitro and in a novel ex vivo gastric gland culture system . Positive_regulation MMP7 HOOK1 23166329 2723336 Treatment with specific inhibitors for AP-1 or NF-?B strongly blocked the [MMP] *up-regulation* by . Positive_regulation MMP7 HPR 13679861 1140738 Moreover , although reactive oxygen species ( ROS ) overproduction appears to be instrumental for <4-HPR> *induced* [MMP] and apoptosis , inhibition of the NF-kappaB or p53 mediated signal transduction pathways failed to modulate 4-HPR induced apoptosis . Positive_regulation MMP7 HPR 13679861 1140760 Cells with a Bax ( -/- ) Bak ( -/- ) genotype were resistant against the <4-HPR> *induced* [MMP] , overproduction of ROS and cell death . Positive_regulation MMP7 HRAS 10811109 692949 Similarly , a farnesyltransferase inhibitor , manumycin A , and a MEK1 inhibitor , U0126 , *suppressed* [MMP] secretion in a dose dependent manner , whereas a PI3 kinase inhibitor , wortmannin , could not . Positive_regulation MMP7 HRAS 19360310 2058277 Taken together , this study clearly demonstrated the inhibitory effect of simvastatin and lovastatin on *induced* invasion , [MMP] expression and signal transduction in MCF10A breast epithelial cells , providing supporting rationale for future statin trials as a therapeutic intervention to regulate breast cancer metastasis . Positive_regulation MMP7 HRG 18600430 1972309 In this study , we show that stimulation remarkably *induced* [MMP-7] promoter activity and significantly enhanced the expression and activity of MMP-7 in MCF-7 cells overexpressing HER2 . Positive_regulation MMP7 HRG 18600430 1972313 Our data suggest that *induced* [MMP-7] expression was regulated by HER2 mediated AP-1 activation in MCF-7 cells . Positive_regulation MMP7 HSPD1 9711934 527052 Chlamydial and human *induce* TNF-alpha and [MMP] production by macrophages . Positive_regulation MMP7 HSPG2 23644655 2926288 We demonstrated that macrophages stimulate cancer cell invasion , motility and migration , and that these effects depend on [matrix metalloproteinase (MMP)] activity and on the *activation* of epidermal growth factor receptor (EGFR) ( at the residue Y ( 1086 ) ) , ( phospholipase C-gamma ) and Gab1 ( GRB2 associated binding protein-1 ) , as evidenced by siRNA ( small interference RNA ) experiments . Positive_regulation MMP7 HSPG2 8705837 343793 also *induced* [MMP] expression in the cultured epithelial cells . Positive_regulation MMP7 HSPG2 8705837 343815 Bacterial may induce degranulation of PMN MMPs and *increase* [MMP] expression in oral epithelial cells . Positive_regulation MMP7 HSPG2 9393778 467914 Gelatin and casein zymography of cell culture medium indicated that the broad-spectrum of Bacillus cereus *induced* [matrix metalloproteinase (MMP)] production in epithelial cells of human skin ( NHEK ) , human gingiva ( HGE ) , and porcine periodontal ligament ( PLE ) . Positive_regulation MMP7 HTRA1 22556410 2614140 Recombinant *induced* [MMP] production in IVD cell cultures through a mechanism critically dependent on MEK but independent of IL-1ß signaling . Positive_regulation MMP7 IFNG 7861007 295313 These data suggest that *enhances* [MMP] gene expression at the post-transcriptional level . Positive_regulation MMP7 IFNG 7872603 296623 IL-2 , IL-6 , and *had* no consistent effect on [MMP] production . Positive_regulation MMP7 IGF1 19493905 2108224 Insulin-like growth factor (IGF) stimulated secretion of matrilysin and IGF-IR/dn blocked mediated [matrilysin] *induction* in three GI cancers . Positive_regulation MMP7 IGF1R 21099348 2377292 Our study suggests that concomitant expression of [MMP-7] and *activation* of ( DP ) correlates with poor prognosis in WT KRAS pts treated with anti-EGFR . Positive_regulation MMP7 IGF2 19493905 2108225 Insulin-like growth factor (IGF) stimulated secretion of matrilysin and IGF-IR/dn blocked mediated [matrilysin] *induction* in three GI cancers . Positive_regulation MMP7 IGFBP1 15590975 1346162 Cell numbers were increased only by 100 nM IGFBP-1 isoforms ( P < 0.05 ) , whereas [MMP] levels released from term cells were optimally *increased* by 1-10 nM . Positive_regulation MMP7 IL10 12945803 1136700 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL10 9892093 558626 In all but one cell line no *enhancement* of [MMP] expression by was detected . Positive_regulation MMP7 IL11 12945803 1136701 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL13 12945803 1136702 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL13 21224056 2379429 Differences between pemphigoid and normal conjunctival fibroblasts with respect to collagen contraction and [MMP] secretion in the *presence* of were also observed . Positive_regulation MMP7 IL13 21858811 2599252 Mechanistically , *enhanced* ERK1/2 , AP-1 and [MMP] activities only in IL-13Ra2 positive cells but not in IL-13Ra2 negative cells . Positive_regulation MMP7 IL15 12945803 1136703 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL15 21247265 2419673 *induced* MC-derived [MMP] production . Positive_regulation MMP7 IL16 12945803 1136704 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL17A 14709335 1196665 ERK pathway inhibitors , PD98059 and U0126 , down-regulated *induced* [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP7 IL17A 15751058 1379921 Moreover , local gene transfer *increased* [MMP] expression without the need for IL-1 , although IL-1 remained essential for part of the cartilage VDIPEN expression . Positive_regulation MMP7 IL17A 19527710 2157349 induces myocardial fibrosis and *enhances* RANKL/OPG and [MMP/TIMP] signaling in isoproterenol induced heart failure . Positive_regulation MMP7 IL18 12945803 1136705 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL19 12945803 1136706 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL1A 10356417 618245 NO also may be involved as a mediator of *induced* expression of [MMP] , mRNA , and protein and may contribute as an activator of the latent forms of the enzymes . Positive_regulation MMP7 IL1A 10553093 565563 In vitro studies showed that SLN-1 is also pivotally involved in *induced* [MMP] activity . Positive_regulation MMP7 IL1A 11327259 807604 A decrease in , IL-1beta , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP7 IL1A 15090411 1237917 and LPS *had* no effect on [MMP/TIMP] production by cultured corneal epithelial cells and keratocytes . Positive_regulation MMP7 IL1A 15201935 1260875 and TNF-alpha are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP7 IL1A 16500223 1528940 *increased* the mRNA expression of MMP-1 and MMP-3 , as well as induced [MMP-7] . Positive_regulation MMP7 IL1A 18050309 1874439 We used an in vitro model system to examine the hypotheses that acute exposure to IL-1 inhibits meniscal repair , and that an mediated *increase* in [matrix metalloproteinase (MMP)] activity is associated with the inhibition of repair . Positive_regulation MMP7 IL1A 20202487 2259365 *increased* [MMP] activity , S-GAG release , and NO production , while decreasing the shear strength and tissue repair in the interface . Positive_regulation MMP7 IL1A 20472558 2283330 We examined adhesion restricted signaling pathways that enable *induced* [MMP] release in human gingival and murine fibroblasts . Positive_regulation MMP7 IL1A 20655064 2424548 *increased* [MMP-7] levels beyond those seen during normal healing . Positive_regulation MMP7 IL1A 20799933 2324449 In OA synoviocytes , HMGB1 alone at concentrations of 15 or 25 ng/ml did not affect the production of IL-6 , IL-8 , CCL2 , CCL20 , MMP-1 or MMP-3 , but in the *presence* of , a significant potentiation of protein and mRNA expression , as well as [MMP] activity was observed . Positive_regulation MMP7 IL1A 21035559 2370187 We have previously reported that up-regulates the expression of Wnt-5A and the activation of Wnt-5A signaling *induces* [matrix metalloproteinase (MMP)] through the c-Jun N-terminal kinase pathway in condylar chondrocytes (CCs) of the temporomandibular joint ( TMJ ) . Positive_regulation MMP7 IL1A 21850498 2574389 We further observed that the levels of *induced* MMP-1 , MMP-3 , [MMP-7] , and MMP-9 mRNA , but not TIMP mRNA levels , were down-regulated in chondrocytes in response to CSE . Positive_regulation MMP7 IL1A 22328140 2630020 The aim of this study was to investigate the role of Wnt/ß-catenin signaling in *induced* [MMP] expression in human chondrocytes . Positive_regulation MMP7 IL1A 22328140 2630232 Wnt/ß-catenin signaling in human chondrocytes had an unexpected anticatabolic role by counteracting NF-?B mediated [MMP] expression *induced* by in a negative feedback loop . Positive_regulation MMP7 IL1A 22415590 2686505 Stimulation of cells with only *resulted* in an overexpression of [MMP] and their TIMP mRNAs . Positive_regulation MMP7 IL1A 22415590 2686529 Proinflammatory cytokine *upregulates* [MMP] and TIMP mRNAs expression in colon cancer epithelial cells Caco-2 . Positive_regulation MMP7 IL1A 22577074 2619337 *induced* [MMP] expression and activation as well as collagen degradation were also blocked by the p38 MAPK inhibitor SB203580 . Positive_regulation MMP7 IL1A 23013178 2679345 rEq *increased* PGE ( 2 ) concentration , sGAG release from explants , chondrocyte apoptosis , and [MMP] gene expression . Positive_regulation MMP7 IL1A 24286132 2877273 Both FN-fs and *increased* NO , PGE2 and [MMP] production ( all P < 0.001 ) . Positive_regulation MMP7 IL1A 24613844 2930017 Notably , *increased* the mRNA expression and subsequent secreted levels of [MMP-7] protein and enhanced the phosphorylation of p38 and ERK mitogen activated protein kinases . Positive_regulation MMP7 IL1A 9162049 431898 [Matrilysin] expression in LNCaP cells was also *induced* by recombinant ( 50 pM ) , but not by equimolar concentrations of recombinant tumor necrosis factor-alpha or IL-6 . Positive_regulation MMP7 IL1A 9538225 497720 sequentially *stimulated* mRNA expression of iNOS , membrane type [1-MMP] , MMP-9 and -3 , and bFGF , in that order . Positive_regulation MMP7 IL1A 9858899 555727 The CAPL protein expressed in cell-cultures appear to block the [MMP] *induction* by bFGF and . Positive_regulation MMP7 IL1B 10727770 678132 and TPA alone *induced* [MMP] activity in HIG-82 cells . Positive_regulation MMP7 IL1B 10864917 705855 and TNF-alpha each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP7 IL1B 10895370 711615 In support of this result , stimulation *induced* the expression of membrane type matrix-metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation MMP7 IL1B 11327259 807605 A decrease in IL-1alpha , , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP7 IL1B 11467889 840806 In all cases , PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on *induction* of [MMP] expression . Positive_regulation MMP7 IL1B 11997239 939305 produced a dose dependent *increase* in [MMP] activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min . Positive_regulation MMP7 IL1B 14872494 1208459 Preincubation with anti-CD44 antibody , which suppressed IL-1beta stimulated MMPs , reversed the inhibitory effect of HA on [MMP] production that was *induced* by in normal and OA cartilage . Positive_regulation MMP7 IL1B 15545168 1337807 [Matrilysin-1] was *up-regulated* by TNF-alpha and , and stromelysin-2 by TNF-alpha and EGF in Caco-2 and WiDr cell cultures . Positive_regulation MMP7 IL1B 16449361 1573884 HA at > or =2 mg/ml significantly inhibited [MMP] production *induced* by in a dose dependent manner . Positive_regulation MMP7 IL1B 16449361 1573906 Inhibition studies revealed the requirement of NF-kappaB , p38 and c-jun NH2-terminal kinase ( JNK ) for *induced* [MMP] production . Positive_regulation MMP7 IL1B 17328062 1711907 SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on *stimulated* [MMP] production and collagen degradation . Positive_regulation MMP7 IL1B 17925024 1835429 These findings demonstrate , for the first time , that glucosamine inhibits *stimulated* [MMP] production in human chondrocytes by affecting MAPK phosphorylation . Positive_regulation MMP7 IL1B 18403593 1899539 DHA significantly decreased VSMC migration/proliferation *induced* by as well as [fibrinolytic/MMP] activity . Positive_regulation MMP7 IL1B 18535174 1928806 *stimulated* [MMP] mRNA synthesis in wild-type , but not in IL-1RI-null cardiac fibroblasts . Positive_regulation MMP7 IL1B 19056796 2017723 Cordycepin is a potent inhibitor of *induced* chemokine production and [MMP] expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs . Positive_regulation MMP7 IL1B 19542681 2099206 *induced* [MMP] production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ) , p38 kinase , and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase (MAPK) family signal transduction molecules . Positive_regulation MMP7 IL1B 20403707 2282294 *induced* [MMP] production was significantly augmented in the presence of sIL-6R . Positive_regulation MMP7 IL1B 21344389 2480450 These findings establish CEBPB as a critical intermediate for dependent [MMP] gene *activation* and assign specific roles for the ERK and RSK kinases in this pathway . Positive_regulation MMP7 IL1B 22792188 2628391 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation MMP7 IL1B 9162049 431896 secreted from monocytic cells *induces* the expression of [matrilysin] in the prostatic cell line LNCaP . Positive_regulation MMP7 IL1B 9558121 500108 Recombinant TNF-alpha and added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP7 IL1B 9821179 548128 The inflammatory cytokine did not *induce* [MMP] or TIMP expression . Positive_regulation MMP7 IL1B 9890433 585425 A beta , but not or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells , as well as *increased* the expression of the well-known activator of MMP-2 , membrane-type ( MT ) [-MMP] . Positive_regulation MMP7 IL1B 9933437 589412 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by and TNF-alpha or down-regulated by IFN-gamma . Positive_regulation MMP7 IL2 12945803 1136707 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL20 12945803 1136708 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL21 12945803 1136709 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL21 16682426 1645806 *enhances* [MMP] secretion without affecting gene transcription and protein synthesis . Positive_regulation MMP7 IL21 17442980 1729752 In this study , we have examined the role of the T cell cytokine IL-21 in Hp-infected gastric mucosa and evaluated whether *regulates* [MMP] production by gastric epithelial cells . Positive_regulation MMP7 IL22 12945803 1136692 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL24 12945803 1136690 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL24 24270662 2926662 *induced* the expression of [matrix metallopeptidase 7 (MMP7)] in SCC cells in culture . Positive_regulation MMP7 IL25 12945803 1136691 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL26 12945803 1136696 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL27 12945803 1136697 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL3 12945803 1136710 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL31 12945803 1136698 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL32 12945803 1136695 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL33 12945803 1136694 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL34 12945803 1136699 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL37 12945803 1136693 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL4 12945803 1136711 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL5 12945803 1136712 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL6 11327259 807606 A decrease in IL-1alpha , IL-1beta , and would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP7 IL6 12945803 1136713 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL6 15996070 1430184 markedly *induced* activation of STAT and extracellular signal related kinase ( ERK1/2 ) and the subsequent expression of the collagenases MMP-1 and MMP-13 as well as MMP-3 , an aggrecan degrading enzyme and activator of [pro-MMP] . Positive_regulation MMP7 IL6 16023653 1525156 The linkage between CEE alone or with a progestin and increased cardiovascular events may be associated with a rise in CRP level , but not through the mechanisms of *mediated* inflammation , endothelial dysfunction or increased [MMP] activity . Positive_regulation MMP7 IL6 17339835 1720162 A *role* for in the regulation of metalloproteinase ( [MMP)-7] expression by CORM-2 is described . Positive_regulation MMP7 IL6 19628948 2142975 In the present study , we investigated the participation of inflammatory cytokine induced mediated matrix metalloproteinase (MMP) expressions and inhibition of *induced* [MMP] secretion in amniotic epithelial cells by tocilizumab . Positive_regulation MMP7 IL6 19628948 2142997 At a low concentration of 1 microg/ml , tocilizumab ( anti-human IL-6 receptor monoclonal antibody ) inhibited the *induced* [MMP] secretion . Positive_regulation MMP7 IL6 20225236 2243863 Although it is known that interleukin (IL)-6 is a key proinflamatory cytokine , it remains unclear how *regulates* [MMP] expression by mononuclear phagocytes . Positive_regulation MMP7 IL6 21059338 2354662 High molecular weight hyaluronic acid inhibits *induced* [MMP] production from human chondrocytes by up-regulating the ERK inhibitor , MKP-1 . Positive_regulation MMP7 IL7 12945803 1136714 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL8 12945803 1136715 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 IL9 12945803 1136716 Furthermore , the *induction* of the [MMP] expression and activities by was suppressed by the oscillatory shear . Positive_regulation MMP7 INHBA 18695873 1950204 *enhances* [MMP-7] activity via the transcription factor AP-1 in an esophageal squamous cell carcinoma cell line . Positive_regulation MMP7 INHBA 18695873 1950205 To reveal the mechanism of expression of [MMP-7] *mediated* by , we evaluated mRNA expression of MMP-7 and Act-betaA with or without activin A neutralizing antibody , using real-time PCR and Northern blot analysis . Positive_regulation MMP7 IQGAP1 18541705 1923572 We further show that the exocyst and are *required* for the accumulation of cell surface membrane type 1 [MMP] at invadopodia . Positive_regulation MMP7 IRF3 20483755 2270077 also partially *regulates* expression of other cytokines and [MMP] through activation of c-Jun and the AP-1 promoter site . Positive_regulation MMP7 IRS1 20525764 2301507 *regulates* the cellular differentiation and the [matrix metallopeptidase] expression of preosteoblastic cells . Positive_regulation MMP7 ITGA2 14973117 1212377 Additionally , activation of the ET ( B ) R pathway increases alpha ( v ) beta ( 3 ) and expression and matrix metalloproteinase (MMP)-2 and MMP-9 , membrane [type-1-MMP] *activation* , and tissue inhibitor MMP-2 secretion . Positive_regulation MMP7 ITGA4 12594231 1060796 may be partially *involved* in the [MMP] induction by COOH-HBFN-f . Positive_regulation MMP7 ITGA5 14529092 1148994 The zymographic analysis showed that ligation of cell surface by alpha5 monoclonal antibody *leads* to the expression and activation of MMP-2 and [MMP-7] in B16F10 melanoma cells . Positive_regulation MMP7 ITGA5 14529092 1148998 induced expression and *activation* of [MMP-2 and -7] indicates the role of tumor cell surface integrin receptor in the modulation of MMPs and , thereby , the invasive property of tumor cells . Positive_regulation MMP7 ITGA5 18243246 1871522 Blocking of with anti-alpha5 monoclonal antibody *inhibits* the fibronectin induced [MMP] activation response appreciably . Positive_regulation MMP7 ITGB1 14529092 1148995 The zymographic analysis showed that ligation of cell surface by alpha5 monoclonal antibody *leads* to the expression and activation of MMP-2 and [MMP-7] in B16F10 melanoma cells . Positive_regulation MMP7 ITGB1 14529092 1148999 *induced* expression and activation of [MMP-2 and -7] indicates the role of tumor cell surface integrin receptor in the modulation of MMPs and , thereby , the invasive property of tumor cells . Positive_regulation MMP7 ITGB1 14973117 1212378 Additionally , activation of the ET ( B ) R pathway increases alpha ( v ) beta ( 3 ) and expression and matrix metalloproteinase (MMP)-2 and MMP-9 , membrane [type-1-MMP] *activation* , and tissue inhibitor MMP-2 secretion . Positive_regulation MMP7 ITGB1 18243246 1871523 Blocking of with anti-alpha5 monoclonal antibody *inhibits* the fibronectin induced [MMP] activation response appreciably . Positive_regulation MMP7 ITIH4 22092673 2514214 Antioxidant gene delivery blunted *induced* [MMP] production . Positive_regulation MMP7 JUN 11861377 917159 These results suggest that nobiletin inhibits tumor cell invasive activity not only by suppressing the expression of MMPs but also augmenting TIMP-1 production in tumor cells , and that the nobiletin mediated inhibition of binding activity is at least partly *involved* in the suppression of [MMP] expression . Positive_regulation MMP7 JUN 17348021 1748221 Here we provide genetic and biochemical evidence that EGF-R- and mediated signals are *required* for [MMP] expression and collagen contraction in fibroblasts . Positive_regulation MMP7 JUN 17696279 1788614 We evaluated whether a vanadium inhibitor could *reduce* [MMP] expression and subsequent joint damage in CIA . Positive_regulation MMP7 JUN 18600430 1972314 Our data suggest that HRG-beta induced [MMP-7] expression was *regulated* by HER2 mediated activation in MCF-7 cells . Positive_regulation MMP7 JUN 21600739 2449957 The results indicate that GlcNAc *inhibited* UVB induced collagenolytic [MMP] production by interfering with Ca ( 2+ ) -dependent Akt and and NF-?B signaling . Positive_regulation MMP7 JUN 21814482 2462833 Taken together , these results suggest that DMA suppresses H2O2 induced cell invasion by inhibiting *mediated* [MMP-7] gene transcription via the JNK/c-Jun and ERK/c-Fos signaling pathways in SW620 human colon cancer cells . Positive_regulation MMP7 JUN 23466236 2766272 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of mitogen activated protein kinase (MAPK) , ATF-2 , and , and [MMP] expression . Positive_regulation MMP7 KDR 18093986 1889738 Inhibition of and VEGF [ by soluble FMS-like tyrosine kinase-1 ( sFlt1 ) ] *down-regulated* visfatin induced [MMP] induction . Positive_regulation MMP7 KITLG 17156777 1694139 peptide *enhances* the expression of u-PA , u-PAR and [MMP-7] while reducing PAI-1 activity . Positive_regulation MMP7 KRAS 10811109 692950 Similarly , a farnesyltransferase inhibitor , manumycin A , and a MEK1 inhibitor , U0126 , *suppressed* [MMP] secretion in a dose dependent manner , whereas a PI3 kinase inhibitor , wortmannin , could not . Positive_regulation MMP7 KRAS 8531010 335154 Expression of matrix metalloproteinase [matrilysin] ( MMP-7 ) was *induced* by activated via AP-1 activation in SW1417 colon cancer cells . Positive_regulation MMP7 LCN2 16446702 1521706 The increased expression of , which *activates* [matrix metalloproteinases (MMP)] , is consistent with our previous findings that MMP-9 and other MMPs are highly expressed in pterygium basal epithelium . Positive_regulation MMP7 LEF1 15457508 1304916 Expression of the T-cell factor , , *enhances* transcriptional activation of the human [MMP-7] promoter by beta-catenin , but represses activation of the mouse MMP-7 promoter , both activities through consensus Tcf binding sites . Positive_regulation MMP7 LEF1 22686279 2615553 *regulates* proliferation and [MMP-7] transcription in breast cancer cells . Positive_regulation MMP7 LEF1 22686279 2615557 Thus , a decrease of expression using LEF-1 siRNA *resulted* in down-regulation of cyclin D and [MMP-7] expression , respectively . Positive_regulation MMP7 LEF1 22686279 2615559 Taken together , our results indicate a pivotal *role* of in the regulation of proliferation and [MMP-7] transcription in breast cancer cells . Positive_regulation MMP7 LEO1 23911909 2840393 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Positive_regulation MMP7 LEP 14629027 1170371 *had* no effect on cytokine and [MMP] production by these cells . Positive_regulation MMP7 LEP 21385940 2416178 *increased* expression and cell surface localization of membrane type 1 [(MT1)-MMP] , measured by cell surface biotinylation assay and antibody based colorimetric detection of an exofacial epitope in intact cells . Positive_regulation MMP7 LGALS1 19276182 2051342 We conclude that is *involved* in tumor invasion and metastasis by increasing [MMP] expression and reorganizing cytoskeletons in oral cancers and lung adenocarcinoma . Positive_regulation MMP7 LOX 20654727 2340585 The inhibitors of COX and/or could *inhibit* cell proliferation , [MMP] activity and invasion in head and neck and colon cancer cells . Positive_regulation MMP7 LPA 16687414 1584177 Overexpression of dominant negative PKCdelta or pretreatment with a PKCdelta inhibitor ( rottlerin ) or Src kinase family inhibitor ( PP2 ) partially blocked induced [MMP] *activation* , proHB-EGF shedding , and EGFR tyrosine phosphorylation . Positive_regulation MMP7 LPA 16687414 1584200 Down-regulation of Lyn kinase , but not Src kinase , by specific small interfering RNA mitigated induced [MMP] *activation* , proHB-EGF shedding , and EGFR phosphorylation . Positive_regulation MMP7 LPA 17114341 1651371 In addition , apparently *induced* the activation of [MMP-7] in DOV13 cells as detected by gelatin zymography . Positive_regulation MMP7 LPA 19019417 2016905 LPA2 mediates *stimulated* HEC1A invasion and the subsequent activation of [MMP-7] . Positive_regulation MMP7 LPA 22348348 2606184 Ki16198 inhibited LPA induced migration and invasion in several pancreatic cancer cells in vitro , which was associated with the inhibition of *induced* [MMP] production . Positive_regulation MMP7 LPAR2 19019417 2016904 *mediates* LPA stimulated HEC1A invasion and the subsequent activation of [MMP-7] . Positive_regulation MMP7 MAP2K1 10811109 692951 Similarly , a Ras farnesyltransferase inhibitor , manumycin A , and a inhibitor , U0126 , *suppressed* [MMP] secretion in a dose dependent manner , whereas a PI3 kinase inhibitor , wortmannin , could not . Positive_regulation MMP7 MAP2K1 15252145 1271567 Therefore , these results introduce novel evidence that the antitumor effects of nobiletin are finely regulated by the following intracellular mechanisms : ( 1 ) the inhibition of activity is *involved* in the suppression of [MMP] expression and ( 2 ) the activation of the novel PKCbetaII/epsilon-JNK pathway is associated with the augmentation of TIMP-1 expression . Positive_regulation MMP7 MAP2K1 19833163 2196190 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP7 MAP2K1 20545600 2308484 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP7 MAP2K1 22310287 2719018 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP7 MAP2K2 19833163 2196191 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP7 MAP2K2 20545600 2308485 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP7 MAP2K2 22310287 2719019 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP7 MAP2K3 19833163 2196192 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP7 MAP2K3 20545600 2308486 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP7 MAP2K3 22310287 2719020 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP7 MAP2K4 19833163 2196193 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP7 MAP2K4 20545600 2308487 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP7 MAP2K4 22310287 2719021 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP7 MAP2K5 19833163 2196194 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP7 MAP2K5 20545600 2308488 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP7 MAP2K5 22310287 2719022 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP7 MAP2K6 19833163 2196195 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP7 MAP2K6 20545600 2308489 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP7 MAP2K6 22310287 2719023 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP7 MAP2K7 19833163 2196196 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP7 MAP2K7 20545600 2308490 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP7 MAP2K7 22310287 2719024 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP7 MAPK1 14517796 1147529 In vitro , cag ( + ) isolates selectively *induce* [MMP-7] , and this is dependent on activation of by specific components within the cag island . Positive_regulation MMP7 MAPK1 16848631 1588337 [Matrix metalloproteinase-7] and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MMP7 MAPK1 17108127 1645459 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP7 MAPK1 17925024 1835430 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP7 MAPK1 21082265 2407465 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP7 MAPK1 22749179 2622898 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP7 MAPK1 23466236 2766273 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP7 MAPK1 24023297 2837542 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP7 MAPK1 24613844 2930019 Furthermore , increased syndecan-2 shedding was dependent on the *mediated* [MMP-7] expression . Positive_regulation MMP7 MAPK10 16848631 1588338 [Matrix metalloproteinase-7] and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MMP7 MAPK10 17108127 1645460 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP7 MAPK10 17925024 1835431 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP7 MAPK10 21082265 2407466 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP7 MAPK10 22749179 2622899 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP7 MAPK10 23466236 2766274 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP7 MAPK10 24023297 2837543 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP7 MAPK10 24613844 2930020 Furthermore , increased syndecan-2 shedding was dependent on the *mediated* [MMP-7] expression . Positive_regulation MMP7 MAPK11 16848631 1588339 [Matrix metalloproteinase-7] and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MMP7 MAPK11 17108127 1645461 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP7 MAPK11 17925024 1835432 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP7 MAPK11 21082265 2407467 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP7 MAPK11 22749179 2622900 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP7 MAPK11 23466236 2766275 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP7 MAPK11 24023297 2837544 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP7 MAPK11 24613844 2930021 Furthermore , increased syndecan-2 shedding was dependent on the *mediated* [MMP-7] expression . Positive_regulation MMP7 MAPK12 16848631 1588340 [Matrix metalloproteinase-7] and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MMP7 MAPK12 17108127 1645462 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP7 MAPK12 17925024 1835433 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP7 MAPK12 21082265 2407468 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP7 MAPK12 22749179 2622901 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP7 MAPK12 23466236 2766276 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP7 MAPK12 24023297 2837545 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP7 MAPK12 24613844 2930022 Furthermore , increased syndecan-2 shedding was dependent on the *mediated* [MMP-7] expression . Positive_regulation MMP7 MAPK13 16848631 1588341 [Matrix metalloproteinase-7] and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MMP7 MAPK13 17108127 1645463 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP7 MAPK13 17925024 1835434 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP7 MAPK13 21082265 2407469 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP7 MAPK13 22749179 2622902 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP7 MAPK13 23466236 2766277 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP7 MAPK13 24023297 2837546 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP7 MAPK13 24613844 2930023 Furthermore , increased syndecan-2 shedding was dependent on the *mediated* [MMP-7] expression . Positive_regulation MMP7 MAPK14 16848631 1588342 [Matrix metalloproteinase-7] and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MMP7 MAPK14 17108127 1645464 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP7 MAPK14 17925024 1835435 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP7 MAPK14 21082265 2407470 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP7 MAPK14 22749179 2622903 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP7 MAPK14 23466236 2766278 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP7 MAPK14 24023297 2837547 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP7 MAPK14 24613844 2930024 Furthermore , increased syndecan-2 shedding was dependent on the *mediated* [MMP-7] expression . Positive_regulation MMP7 MAPK15 16848631 1588336 [Matrix metalloproteinase-7] and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MMP7 MAPK15 17108127 1645457 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP7 MAPK15 17925024 1835428 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP7 MAPK15 21082265 2407464 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP7 MAPK15 22749179 2622897 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP7 MAPK15 23466236 2766271 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP7 MAPK15 24023297 2837541 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP7 MAPK15 24613844 2930018 Furthermore , increased syndecan-2 shedding was dependent on the *mediated* [MMP-7] expression . Positive_regulation MMP7 MAPK3 14517796 1147530 In vitro , cag ( + ) isolates selectively *induce* [MMP-7] , and this is dependent on activation of by specific components within the cag island . Positive_regulation MMP7 MAPK3 16848631 1588343 [Matrix metalloproteinase-7] and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MMP7 MAPK3 17108127 1645465 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP7 MAPK3 17925024 1835436 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP7 MAPK3 21082265 2407471 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP7 MAPK3 22749179 2622904 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP7 MAPK3 23466236 2766279 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP7 MAPK3 24023297 2837548 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP7 MAPK3 24613844 2930025 Furthermore , increased syndecan-2 shedding was dependent on the *mediated* [MMP-7] expression . Positive_regulation MMP7 MAPK4 16848631 1588344 [Matrix metalloproteinase-7] and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MMP7 MAPK4 17108127 1645466 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP7 MAPK4 17925024 1835437 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP7 MAPK4 21082265 2407472 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP7 MAPK4 22749179 2622905 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP7 MAPK4 23466236 2766280 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP7 MAPK4 24023297 2837549 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP7 MAPK4 24613844 2930026 Furthermore , increased syndecan-2 shedding was dependent on the *mediated* [MMP-7] expression . Positive_regulation MMP7 MAPK6 16848631 1588345 [Matrix metalloproteinase-7] and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MMP7 MAPK6 17108127 1645467 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP7 MAPK6 17925024 1835438 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP7 MAPK6 21082265 2407473 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP7 MAPK6 22749179 2622906 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP7 MAPK6 23466236 2766281 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP7 MAPK6 24023297 2837550 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP7 MAPK6 24613844 2930027 Furthermore , increased syndecan-2 shedding was dependent on the *mediated* [MMP-7] expression . Positive_regulation MMP7 MAPK7 16848631 1588346 [Matrix metalloproteinase-7] and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MMP7 MAPK7 17108127 1645468 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP7 MAPK7 17925024 1835439 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP7 MAPK7 21082265 2407474 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP7 MAPK7 22749179 2622907 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP7 MAPK7 23466236 2766282 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP7 MAPK7 24023297 2837551 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP7 MAPK7 24613844 2930028 Furthermore , increased syndecan-2 shedding was dependent on the *mediated* [MMP-7] expression . Positive_regulation MMP7 MAPK8 11920420 926256 Complete inhibition of [MMP] expression and joint destruction will likely *require* combined and JNK-2 inhibition . Positive_regulation MMP7 MAPK8 16848631 1588347 [Matrix metalloproteinase-7] and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MMP7 MAPK8 17108127 1645469 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP7 MAPK8 17925024 1835440 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP7 MAPK8 21082265 2407475 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP7 MAPK8 22749179 2622908 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP7 MAPK8 23466236 2766283 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP7 MAPK8 24023297 2837552 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP7 MAPK8 24613844 2930029 Furthermore , increased syndecan-2 shedding was dependent on the *mediated* [MMP-7] expression . Positive_regulation MMP7 MAPK9 11920420 926257 Complete inhibition of [MMP] expression and joint destruction will likely *require* combined JNK-1 and inhibition . Positive_regulation MMP7 MAPK9 16848631 1588348 [Matrix metalloproteinase-7] and epidermal growth factor receptor mediate hypoxia *induced* extracellular signal regulated kinase 1/2 activation and subsequent proliferation in bladder smooth muscle cells . Positive_regulation MMP7 MAPK9 17108127 1645470 In addition , we showed that the c-Jun NH ( 2 ) -terminal kinase , but not extracellular signal regulated kinase 1/2 or p38 , signaling pathway was *critical* for GnRH mediated up-regulation of [MMP] , cell invasion , and motility . Positive_regulation MMP7 MAPK9 17925024 1835441 These findings demonstrate , for the first time , that glucosamine *inhibits* IL-1beta stimulated [MMP] production in human chondrocytes by affecting phosphorylation . Positive_regulation MMP7 MAPK9 21082265 2407476 All the inhibitors slightly *enhanced* cell growth inhibition , death and [MMP] ( ??m ) loss , and increased ROS levels in PG-treated HeLa cells . Positive_regulation MMP7 MAPK9 22749179 2622909 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP7 MAPK9 23466236 2766284 In UVB irradiated HaCaT cells , 8-oxo-dG inhibited ROS production , subsequent *activation* of , ATF-2 , and c-Jun , and [MMP] expression . Positive_regulation MMP7 MAPK9 24023297 2837553 After treatments of Hep3B cells with fluoxetine , we measured cell viability , reactive oxygen species ( ROS ) , mitochondrial [membrane potential (MMP)] and *activation* of . Positive_regulation MMP7 MAPK9 24613844 2930030 Furthermore , increased syndecan-2 shedding was dependent on the *mediated* [MMP-7] expression . Positive_regulation MMP7 MIF 16872482 1663473 In the present study , we determined the *role* of in RA synovial fibroblast [MMP] production and the underlying signaling mechanisms . Positive_regulation MMP7 MIF 19950249 2184917 The use of different strategies to block MIF action , including an anti-MIF antibody , the MIF inhibitor ISO-1 and knockout mice for the MIF gene , showed that cytokine secretion and [MMP] expression during infection were *regulated* by , suggesting that this cytokine acts in autocrine and paracrine manner upstream in the macrophage activation cascade . Positive_regulation MMP7 MME 20874839 2343107 In the *presence* of , substance P levels in supernatants as well as [MMP] production and the invasive potency of SCC were significantly augmented compared with control scramble RNA transfected Fb . Positive_regulation MMP7 MMP1 14647460 1173338 Synthetic inhibitors *inhibited* both the membrane binding of [matrilysin] and matrilysin induced cell aggregation , while TIMP-2 inhibited only the cell aggregation . Positive_regulation MMP7 MMP10 14647460 1173339 Synthetic inhibitors *inhibited* both the membrane binding of [matrilysin] and matrilysin induced cell aggregation , while TIMP-2 inhibited only the cell aggregation . Positive_regulation MMP7 MMP10 15545168 1337808 [Matrilysin-1] was *up-regulated* by TNF-alpha and IL-1 beta , and by TNF-alpha and EGF in Caco-2 and WiDr cell cultures . Positive_regulation MMP7 MMP11 14647460 1173340 Synthetic inhibitors *inhibited* both the membrane binding of [matrilysin] and matrilysin induced cell aggregation , while TIMP-2 inhibited only the cell aggregation . Positive_regulation MMP7 MMP12 14647460 1173341 Synthetic inhibitors *inhibited* both the membrane binding of [matrilysin] and matrilysin induced cell aggregation , while TIMP-2 inhibited only the cell aggregation . Positive_regulation MMP7 MMP13 14647460 1173342 Synthetic inhibitors *inhibited* both the membrane binding of [matrilysin] and matrilysin induced cell aggregation , while TIMP-2 inhibited only the cell aggregation . Positive_regulation MMP7 MMP13 23722213 2801751 Additionally , the addition of specific and MMP14 inhibitors *prevented* the [MMP] activities of supernatants collected from 4T1 cells incubated with D1CM , CCL5 or CCL9 . Positive_regulation MMP7 MMP14 14647460 1173343 Synthetic inhibitors *inhibited* both the membrane binding of [matrilysin] and matrilysin induced cell aggregation , while TIMP-2 inhibited only the cell aggregation . Positive_regulation MMP7 MMP14 23722213 2801752 Additionally , the addition of specific MMP9/MMP13 and inhibitors *prevented* the [MMP] activities of supernatants collected from 4T1 cells incubated with D1CM , CCL5 or CCL9 . Positive_regulation MMP7 MMP15 14647460 1173344 Synthetic inhibitors *inhibited* both the membrane binding of [matrilysin] and matrilysin induced cell aggregation , while TIMP-2 inhibited only the cell aggregation . Positive_regulation MMP7 MMP16 14647460 1173345 Synthetic inhibitors *inhibited* both the membrane binding of [matrilysin] and matrilysin induced cell aggregation , while TIMP-2 inhibited only the cell aggregation . Positive_regulation MMP7 MMP17 14647460 1173346 Synthetic inhibitors *inhibited* both the membrane binding of [matrilysin] and matrilysin induced cell aggregation , while TIMP-2 inhibited only the cell aggregation . Positive_regulation MMP7 MMP19 14647460 1173347 Synthetic inhibitors *inhibited* both the membrane binding of [matrilysin] and matrilysin induced cell aggregation , while TIMP-2 inhibited only the cell aggregation . Positive_regulation MMP7 MMP2 10333542 615136 *Activation* of by membrane type-MMP ( [MT-MMP] ) is reported to be a rate limiting step for catalytic function . Positive_regulation MMP7 MMP2 10642509 660863 Both in the insect cells and in vitro , *activation* of by [fMT1-MMP] was enhanced at low concentrations of TIMP-2 and inhibited by its higher concentrations . Positive_regulation MMP7 MMP2 10642509 660928 In contrast , *activation* of by [sMT1-MMP] was dose-dependently inhibited by TIMP-2 . Positive_regulation MMP7 MMP2 11114732 759290 In addition , activation of [MMP-secretion] and tyrosine phosphorylation of FAK by Con A , but not the proteolytic *activation* of , required attachment of the cells to the extracellular matrix . Positive_regulation MMP7 MMP2 11340084 812375 The Rac1 dependent activation occurred in a cell associated fashion and *required* [MMP] activities . Positive_regulation MMP7 MMP2 11382769 835068 In contrast to the stimulatory effect of TIMP-2 on pro-MMP-2 activation by MT1-MMP , *activation* of by [DeltaMT1-MMP] in the presence of claudin-5 and proDeltaMMP-2 processing by MT1-MMP were both inversely repressed by expression of exogenous TIMP-2 . Positive_regulation MMP7 MMP2 14647460 1173348 Synthetic inhibitors *inhibited* both the membrane binding of [matrilysin] and matrilysin induced cell aggregation , while TIMP-2 inhibited only the cell aggregation . Positive_regulation MMP7 MMP2 15530852 1332778 Both recombinant human TIMP-1 and the synthetic [MMP] *inhibitors* , GM6001 and Inhibitor III , suppressed migration of human dermal microvascular endothelial cells ( HDMVEC ) in a dose dependent fashion . Positive_regulation MMP7 MMP2 15782307 1403688 The induction of these MMPs likely contributes to tissue destruction associated with the fibrogenic process , while augmenting the *activation* of and MMP-9 by MMP-3 and [MMP-7] in XLAS . Positive_regulation MMP7 MMP2 16152587 1517321 Using Western blotting , we show that VEGF , at 20-80 ng/ml , induced secretion of [pro-MMP-7] and pro-MMP-9 and *activation* of in DOV13 conditioned medium in a concentration dependent manner . Positive_regulation MMP7 MMP2 17986262 1845903 These results suggest that , during colon morphogenesis , [MMP] activity is under strict spatio-temporal control , and that the activity of , which is regulated at both the transcriptional and proteolytic activation levels , is very much *involved* in rat colon morphogenesis . Positive_regulation MMP7 MMP2 19224446 2039834 *Activation* of by membrane type [1-MMP] and abnormal immunolocalization of the basement membrane components laminin and type IV collagen in canine spontaneous hemangiosarcomas . Positive_regulation MMP7 MMP2 2174435 145675 collagenase mRNA increased approximately 16-fold , increased 2-fold , and [Pump-1] , a recently described MMP gene , was *induced* . Positive_regulation MMP7 MMP2 22729485 2644247 Specific inhibitors to MMPs revealed that [MMP] activity was *due* to . Positive_regulation MMP7 MMP2 7822314 293047 The expression of [MT-MMP] *induced* specific activation of 72-kDa ( Sato , H. , Takino , T. , Okada , Y. , Cao , J. , Shinagawa , A. , Yamamoto , E. , and Seiki , M. ( 1994 ) Nature 370 , 61-65 ) . Positive_regulation MMP7 MMP20 14647460 1173349 Synthetic inhibitors *inhibited* both the membrane binding of [matrilysin] and matrilysin induced cell aggregation , while TIMP-2 inhibited only the cell aggregation . Positive_regulation MMP7 MMP21 14647460 1173336 Synthetic inhibitors *inhibited* both the membrane binding of [matrilysin] and matrilysin induced cell aggregation , while TIMP-2 inhibited only the cell aggregation . Positive_regulation MMP7 MMP24 14647460 1173350 Synthetic inhibitors *inhibited* both the membrane binding of [matrilysin] and matrilysin induced cell aggregation , while TIMP-2 inhibited only the cell aggregation . Positive_regulation MMP7 MMP25 14647460 1173333 Synthetic inhibitors *inhibited* both the membrane binding of [matrilysin] and matrilysin induced cell aggregation , while TIMP-2 inhibited only the cell aggregation . Positive_regulation MMP7 MMP26 14647460 1173334 Synthetic inhibitors *inhibited* both the membrane binding of [matrilysin] and matrilysin induced cell aggregation , while TIMP-2 inhibited only the cell aggregation . Positive_regulation MMP7 MMP27 14647460 1173335 Synthetic inhibitors *inhibited* both the membrane binding of [matrilysin] and matrilysin induced cell aggregation , while TIMP-2 inhibited only the cell aggregation . Positive_regulation MMP7 MMP28 14647460 1173337 Synthetic inhibitors *inhibited* both the membrane binding of [matrilysin] and matrilysin induced cell aggregation , while TIMP-2 inhibited only the cell aggregation . Positive_regulation MMP7 MMP3 11979071 934839 Because MMP-3 , [MMP-7] , MMP-9 are known to degrade elastin , and can *activate* the latent forms of MMP-7 and MMP-9 , we propose that these metalloproteinases also participate in the degradation of elastic fibers in anetodermic skin . Positive_regulation MMP7 MMP3 14647460 1173351 Synthetic inhibitors *inhibited* both the membrane binding of [matrilysin] and matrilysin induced cell aggregation , while TIMP-2 inhibited only the cell aggregation . Positive_regulation MMP7 MMP3 18283281 1919308 Mphi conditioned media ( Mphi-CM ) increased the levels of TNF-alpha mRNA expression in 3T3-L1 adipocytes , and these adipocyte responses were abolished by treatment with GM6001 , a broad-spectrum [MMP] *inhibitor* , or NNGH ( N-isobutyl-N- ( 4-methoxyphenylsulfonyl ) -glycylhydroxamic acid ) , an inhibitor . Positive_regulation MMP7 MMP7 14647460 1173352 Synthetic inhibitors *inhibited* both the membrane binding of [matrilysin] and matrilysin induced cell aggregation , while TIMP-2 inhibited only the cell aggregation . Positive_regulation MMP7 MMP8 14647460 1173353 Synthetic inhibitors *inhibited* both the membrane binding of [matrilysin] and matrilysin induced cell aggregation , while TIMP-2 inhibited only the cell aggregation . Positive_regulation MMP7 MMP9 11971672 933664 Zymography demonstrated a dose dependent *increase* in 92-kDa [MMP] ( pro-MMP-9 ) activity ( P < 0.001 ) with corresponding increases in protein ( P = 0.03 ) and mRNA levels ( P = 0.004 ) . Positive_regulation MMP7 MMP9 14647460 1173354 Synthetic inhibitors *inhibited* both the membrane binding of [matrilysin] and matrilysin induced cell aggregation , while TIMP-2 inhibited only the cell aggregation . Positive_regulation MMP7 MMP9 15530852 1332779 Both recombinant human TIMP-1 and the synthetic [MMP] *inhibitors* , GM6001 and Inhibitor III , suppressed migration of human dermal microvascular endothelial cells ( HDMVEC ) in a dose dependent fashion . Positive_regulation MMP7 MMP9 15782307 1403689 The induction of these MMPs likely contributes to tissue destruction associated with the fibrogenic process , while augmenting the *activation* of MMP-2 and by MMP-3 and [MMP-7] in XLAS . Positive_regulation MMP7 MMP9 20226090 2223657 Levels of [MMP-7] , -8 and TIMP-1 decreased nearly to those of non-smokers but the levels of *increased* significantly from the baseline of the same subjects at 3 months after cessation ( p = 0.009 ) with no significant decline at 6 months after cessation . Positive_regulation MMP7 MMP9 23722213 2801753 Additionally , the addition of specific and MMP14 inhibitors *prevented* the [MMP] activities of supernatants collected from 4T1 cells incubated with D1CM , CCL5 or CCL9 . Positive_regulation MMP7 MOAP1 22749179 2622896 These results indicate that CG *inhibits* UVB induced collagenolytic [MMP] production by interfering with and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging . Positive_regulation MMP7 MPZ 19851865 2203234 The loss of [MMP] *induced* by was preventive by DbetaHB . Positive_regulation MMP7 MSH2 16511523 1574335 Further , significantly *increased* [matrix metalloproteinase (MMP)] , while tissue inhibitors of matrix metalloproteinase ( TIMPs ) were inactivated . Positive_regulation MMP7 MSH3 16511523 1574336 Further , significantly *increased* [matrix metalloproteinase (MMP)] , while tissue inhibitors of matrix metalloproteinase ( TIMPs ) were inactivated . Positive_regulation MMP7 MSH4 16511523 1574337 Further , significantly *increased* [matrix metalloproteinase (MMP)] , while tissue inhibitors of matrix metalloproteinase ( TIMPs ) were inactivated . Positive_regulation MMP7 MSH5 16511523 1574338 Further , significantly *increased* [matrix metalloproteinase (MMP)] , while tissue inhibitors of matrix metalloproteinase ( TIMPs ) were inactivated . Positive_regulation MMP7 MSH6 16511523 1574339 Further , significantly *increased* [matrix metalloproteinase (MMP)] , while tissue inhibitors of matrix metalloproteinase ( TIMPs ) were inactivated . Positive_regulation MMP7 MSLN 21999204 2547393 *regulated* the expression of [MMP-7] through the ERK ( extracellular-signal regulated kinase ) 1/2 , Akt and JNK ( c-Jun N-terminal kinase ) pathways . Positive_regulation MMP7 MSLN 22371455 2587040 expression *promotes* MPM cell invasion and [MMP] secretion in both human and murine MPM cells . Positive_regulation MMP7 MST1 907425 6440 [MMP-and] *induced* cells catalyze the oxidation of a variety of substituted phenols . Positive_regulation MMP7 MTA1 21356366 2394731 *induced* [matrix metalloproteinase (MMP)] and interleukin-8 transcription in HCC cells in vitro , accompanied by enhanced proliferation and activation of the transcription factor NF?B . Positive_regulation MMP7 MTA2 21356366 2394732 *induced* [matrix metalloproteinase (MMP)] and interleukin-8 transcription in HCC cells in vitro , accompanied by enhanced proliferation and activation of the transcription factor NF?B . Positive_regulation MMP7 MTA3 21356366 2394730 *induced* [matrix metalloproteinase (MMP)] and interleukin-8 transcription in HCC cells in vitro , accompanied by enhanced proliferation and activation of the transcription factor NF?B . Positive_regulation MMP7 MTOR 18375114 1899004 Furthermore , inhibitor rapamycin not only drastically *inhibited* migration and [MMP] production , but also induced type II programmed cell death , autophagic cell death . Positive_regulation MMP7 MUC1 18436821 1900350 [Matrix metalloproteinase-7] and neutrophil elastase *induced* the release of MUC16 but not of or MUC4 . Positive_regulation MMP7 MUC16 18436821 1900349 [Matrix metalloproteinase-7] and neutrophil elastase *induced* the release of but not of MUC1 or MUC4 . Positive_regulation MMP7 MUC4 18436821 1900351 [Matrix metalloproteinase-7] and neutrophil elastase *induced* the release of MUC16 but not of MUC1 or . Positive_regulation MMP7 MYL2 19961849 2204138 Further , drug *induced* effects on actin cytoskeletal organization , cell adhesions , phosphorylation , [matrix metalloproteinase (MMP)] activity , and cytoskeletal protein profile in porcine trabecular meshwork ( TM ) cells were determined by immunofluorescence , zymography , and mass spectrometry . Positive_regulation MMP7 MYLIP 23333633 2747201 *increased* the [MMP] inhibitor RECK protein in MDA-MB-231 cells while pre-miR-182 reduced RECK protein but not mRNA in normal mammary epithelial H184B5F5/M10 cells . Positive_regulation MMP7 MYLIP 24447911 2923093 These results indicate that Ang II-induced CF migration is differentially regulated by mediated [MMP] *induction* and RECK suppression , and that DHA has the potential to upregulate RECK , and therefore may exert potential beneficial effects in cardiac fibrosis . Positive_regulation MMP7 MYLIP 24812324 2944922 Mechanistically , *stimulated* [MMP] activity in the aortic wall by directly targeting 2 MMP inhibitors : tissue inhibitor of metalloproteinase 3 ( TIMP3 ) and reversion inducing cysteine-rich protein with kazal motifs ( RECK ) . Positive_regulation MMP7 NA 20043100 2192854 GSH and , an anti-oxidant agent , *blocked* the curcumin induced ROS production , [MMP] loss and rescued cells from curcumin induced apoptosis . Positive_regulation MMP7 NA 23352441 2747595 Phagocytosis , the loss of [MMP] , autophagy and the activated signaling pathways were all *suppressed* by ROS scavenger , H2O2 scavenger catalase or OH scavenger glutathione ( GSH ) . Positive_regulation MMP7 NAA25 18653469 1967104 and Kaiso regulate Helicobacter pylori *induced* expression of [matrix metalloproteinase-7] . Positive_regulation MMP7 NAMPT 18093986 1889737 Inhibition of VEGFR2 and VEGF [ by soluble FMS-like tyrosine kinase-1 ( sFlt1 ) ] down-regulated *induced* [MMP] induction . Positive_regulation MMP7 NAMPT 18093986 1889765 Inhibition of PI3K/Akt and ERK ( 1/2 ) pathways led to significant decrease of *induced* [MMP] and VEGF production and activation , along with significant reduction in endothelial proliferation and capillary tube formation . Positive_regulation MMP7 NAMPT 18093986 1889788 Our data provide the first evidence of *induced* endothelial VEGF and [MMP] production and activity . Positive_regulation MMP7 NFKB1 16423269 1515351 A specific inhibitor of *reduced* [MMP] production by alveolar macrophages from SP-D-/- mice . Positive_regulation MMP7 NFKB1 19320561 2162364 Hence , induction of by shear stress *contributes* to [MMP] induction and allows long-term flow induced vascular enlargement . Positive_regulation MMP7 NFKB1 19639210 2113217 These data suggest that VK2 *inhibits* [MMP] expression by suppressing and MAP kinase activity and might be potentially useful in the treatment of HCC . Positive_regulation MMP7 NOX1 22120495 2535174 After 3h exposure to a reducing extracellular redox state ( E ( h ) CySS=-180mV ) , [matrix metalloprotease (MMP)] , gelatinase , and activities *increased* , correlating with increases in cell invasion , cell migration , and extracellular hydrogen peroxide levels in PC3 cells but not PrECs . Positive_regulation MMP7 NOX3 22120495 2535175 After 3h exposure to a reducing extracellular redox state ( E ( h ) CySS=-180mV ) , [matrix metalloprotease (MMP)] , gelatinase , and activities *increased* , correlating with increases in cell invasion , cell migration , and extracellular hydrogen peroxide levels in PC3 cells but not PrECs . Positive_regulation MMP7 NOX4 22120495 2535176 After 3h exposure to a reducing extracellular redox state ( E ( h ) CySS=-180mV ) , [matrix metalloprotease (MMP)] , gelatinase , and activities *increased* , correlating with increases in cell invasion , cell migration , and extracellular hydrogen peroxide levels in PC3 cells but not PrECs . Positive_regulation MMP7 NOX5 22120495 2535173 After 3h exposure to a reducing extracellular redox state ( E ( h ) CySS=-180mV ) , [matrix metalloprotease (MMP)] , gelatinase , and activities *increased* , correlating with increases in cell invasion , cell migration , and extracellular hydrogen peroxide levels in PC3 cells but not PrECs . Positive_regulation MMP7 NPR1 15710627 1402759 Our results show that reduced signaling *activates* [MMP] , transforming growth factor-beta1 , and TNF-alpha expression in Npr1-/- mouse hearts . Positive_regulation MMP7 NPS 9766654 538555 These data indicate that can *regulate* [MMP] activity , which , in turn , could facilitate prostate cancer progression . Positive_regulation MMP7 NR4A1 24851101 2940551 Simvastatin induced NR4A1 expression in RAW 264.7 macrophages and ectopic expression of a dominant negative mutant form of effectively *suppressed* both DNA fragmentation and the disruption of mitochondrial [membrane potential (MMP)] during LPS- and simvastatin induced apoptosis . Positive_regulation MMP7 NRAS 10811109 692952 Similarly , a farnesyltransferase inhibitor , manumycin A , and a MEK1 inhibitor , U0126 , *suppressed* [MMP] secretion in a dose dependent manner , whereas a PI3 kinase inhibitor , wortmannin , could not . Positive_regulation MMP7 OSM 11207308 786955 We have previously shown that *induces* [MMP] and tissue inhibitor of metalloproteinase-3 ( TIMP-3 ) gene expression in chondrocytes by protein tyrosine kinase dependent mechanisms . Positive_regulation MMP7 OSM 11207308 787000 In the present study , we investigated signaling pathways regulating the *induction* of [MMP] and TIMP-3 genes by . Positive_regulation MMP7 OSM 11207308 787044 Thus , *induces* [MMP] and TIMP-3 genes in chondrocytes by activating JAK/STAT and mitogen activated protein kinase signaling cascades , and interference with these pathways may be a useful approach to block the catabolic actions of OSM . Positive_regulation MMP7 OSM 14673992 1178651 The in vivo data clearly indicated that + TNFalpha overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP7 OSM 16549372 1582265 TNF-alpha and induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP7 OSM 17469134 1737541 and TNF *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP7 OTUD7A 23792447 2937865 Further , could *regulate* [MMP] ( matrix metalloproteinase)2 , MMP9 and ICAM1 ( intercellular adhesion molecule ) levels through modulation of the NF-?B ( nuclear factor kappa-light-chain-enhancer of activated B cell ) signaling cascade . Positive_regulation MMP7 PAF1 23911909 2840391 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Positive_regulation MMP7 PAK1 23744893 2807166 Together , these data illustrate the complex interaction between the substratum and PRL/PAK1 signaling in human breast cancer cells and suggest a pivotal *role* for PRL dependent tyrosyl phosphorylation in [MMP] secretion . Positive_regulation MMP7 PAK2 20111678 2178730 In the present study , we examined the effects of resveratrol on apoptotic biochemical events in Hep G2 cells induced by CTN. Resveratrol inhibited CTN induced ROS generation , activation of JNK , loss of mitochondrial [membrane potential (MMP)] , as well as *activation* of caspase-9 , caspase-3 and . Positive_regulation MMP7 PBX2 20637111 2297481 G17 studies designed following small interference RNA ( siRNA ) -mediated knockdown of Snail and beta-catenin expression indicated a significant reduction of *induced* migration and [MMP7] promoter induction following combined knockdown of both proteins . Positive_regulation MMP7 PDGFB 18489818 1939183 So , may *induce* the expression of [MMP] for the degradation of collagen type III on the wall of the saccular aneurysms . Positive_regulation MMP7 PDLIM7 12756268 1090691 *triggers* mitochondrial [membrane permeabilization (MMP)] , as detected by the release of cytochrome c . Positive_regulation MMP7 PDLIM7 17913445 1812881 To investigate the *role* of in [MMP] expression in NPC , we cloned the LMP1 gene from NPC samples and transiently expressed it in MRC5 cells ( human lung fibroblasts ) . Positive_regulation MMP7 PEBP4 24276246 2955807 Further investigation showed that *promoted* the expression or activity of the metastasis related proteinases [MMP] ( matrix metalloproteinase) 2 , MMP9 and MMP13 . Positive_regulation MMP7 PGF 11870075 918359 [MMP] activity was localized ( in situ zymography ) to the pericellular area of various cell types in the 0-h group and was markedly *increased* by 30 min ( 2 alpha ) . Positive_regulation MMP7 PI3 20230795 2237673 This involves activation of integrins and focal adhesion formation via inside-out dependent signaling , but does not *require* [MMP] activation . Positive_regulation MMP7 PIK3CA 16142341 1451297 Inhibition of signaling in LM8 by a PI3K inhibitor , LY294002 , or by a dominant negative form of Akt , *resulted* in suppression of [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Positive_regulation MMP7 PIK3R1 16142341 1451298 Inhibition of signaling in LM8 by a PI3K inhibitor , LY294002 , or by a dominant negative form of Akt , *resulted* in suppression of [MMP] secretion , in vitro invasiveness , cell locomotion and in vivo pulmonary metastasis . Positive_regulation MMP7 PLA2G4A 17981679 1845564 [MMP] production in human fibrosarcoma cells and their invasiveness are *regulated* by group IB secretory phospholipase A2 receptor mediated activation of . Positive_regulation MMP7 PLA2R1 17981679 1845565 [MMP] production in human fibrosarcoma cells and their invasiveness are *regulated* by group IB mediated activation of cytosolic phospholipase A2 . Positive_regulation MMP7 PLG 11204721 785555 The [MMP] are *regulated* at the levels of transcription , zymogen activation by or membrane-type- ( MT ) MMP , and control of enzyme activity by tissue inhibitors of metalloproteinases ( TIMP ) . Positive_regulation MMP7 PLG 11387497 821867 Plasminogen activators (PAs) may also play a role in ECM degradation by the generation of or by [MMP] *activation* . Positive_regulation MMP7 PLG 16391791 1505826 On the other hand , *induced* the expression of matrix metalloproteinase-2 (MMP-2) , [MMP-7] and MMP-9 in PC-1 cells . Positive_regulation MMP7 PLG 21311679 2360087 Plasminogen activator inhibitor (PAI)-1 is known to play an important role in renal ECM accumulation in part through suppression of generation and [matrix metalloproteinase (MMP)] *activation* . Positive_regulation MMP7 PLG 21465481 2523812 During wound healing , elevated levels of PAI-1 inhibit uPA/tPA/plasmin and *dependent* [MMP] activities , and , thus , help expedite wound healing . Positive_regulation MMP7 PLG 22798012 2645695 This effect resulted from the presence of the potent [MMP] *inhibitors* , tissue inhibitor of metalloproteinases-1 ( TIMP-1 ) , type-1 activator inhibitor ( PAI-1 ) and thrombospondin-1 (TSP-1) in the amnion dressings , as shown by real-time fluorescence zymography and protein microarrays . Positive_regulation MMP7 PODXL 17616675 1769342 These findings suggest that leads to increased in vitro migration and invasion , *increased* [MMP] expression , and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MMP7 POLDIP2 20230795 2237672 This involves activation of integrins and focal adhesion formation via inside-out dependent signaling , but does not *require* [MMP] activation . Positive_regulation MMP7 POLDIP2 20377132 2239209 In contrast , inhibitor *reduced* cell growth inhibition , apoptosis , and [MMP] ( deltapsi ( m ) ) loss by MG132 . Positive_regulation MMP7 PRG2 10220591 609318 The degradation of was *inhibited* by and [MMP] inhibitor , indicating that MMPs are involved in the degradation of proteoglycans induced by high frequency CTF . Positive_regulation MMP7 PRG3 10220591 609319 The degradation of was *inhibited* by and [MMP] inhibitor , indicating that MMPs are involved in the degradation of proteoglycans induced by high frequency CTF . Positive_regulation MMP7 PRG4 10220591 609320 The degradation of was *inhibited* by and [MMP] inhibitor , indicating that MMPs are involved in the degradation of proteoglycans induced by high frequency CTF . Positive_regulation MMP7 PRKAA1 24255018 2904294 Adiponectin mediated signaling *induces* cell migration , [MMP] activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation MMP7 PRKAA2 24255018 2904295 Adiponectin mediated signaling *induces* cell migration , [MMP] activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation MMP7 PRKAB1 24255018 2904296 Adiponectin mediated signaling *induces* cell migration , [MMP] activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation MMP7 PRKAB2 24255018 2904297 Adiponectin mediated signaling *induces* cell migration , [MMP] activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation MMP7 PRKAG1 24255018 2904298 Adiponectin mediated signaling *induces* cell migration , [MMP] activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation MMP7 PRKAG2 24255018 2904299 Adiponectin mediated signaling *induces* cell migration , [MMP] activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation MMP7 PRSS2 22909050 2678112 *activated* [proMT1-MMP] , as well as altered the expression of TJ protein claudin-7 . Positive_regulation MMP7 PTGER4 8679543 365818 *Stimulation* of [MMP] activities in RNK-16 cells by the thus facilitates migration of the NK cells across vascular basement membranes . Positive_regulation MMP7 PTGS2 17934334 1813424 Selective COX-2 inhibitors , NS-398 and celecoxib , inhibited cell proliferation and abrogated the enhanced mobility , invasiveness and [MMP] activities *induced* by overexpression . Positive_regulation MMP7 PTGS2 23790336 2802592 The abnormal expressions of COX-2 and MMP-7 are closely related to the biological behavior of OSCC , the [MMP-7] may be *induced* by , and further lead to the invasion and metastasis of OSCC . Positive_regulation MMP7 PTH 14570746 1155589 Although parathyroid tissue induces angiogenesis when autotransplanted and *regulates* both VEGF and [MMP] expression , there are few studies of angiogenesis and angiogenic factors in parathyroid tumors . Positive_regulation MMP7 PTP4A3 22131018 2599621 It was found that *induced* [MMP-7] through oncogenic pathways including PI3K/AKT and ERK and that there is a relationship between the expression of PRL-3 and MMP-7 in human tumor cell lines . Positive_regulation MMP7 PTP4A3 23589069 2778599 accordingly , inhibition of also prevented ERK1/2 protein and mRNA expression , and *reduced* the mRNA level of [matrix metalloproteinase-7 (MMP-7)] , the downstream target of ERK 1/2 signaling . Positive_regulation MMP7 RAC1 11340084 812376 The dependent MMP-2 activation occurred in a cell associated fashion and *required* [MMP] activities . Positive_regulation MMP7 RAG2 22213029 2585986 also *prevented* the loss of mitochondrial [membrane potential (MMP)] , alterations in levels of two key mitochondrial Bcl-2 family proteins , and the accumulation of numerous cells into the sub-G ( 1 ) phase that were observed in serum starved osteoblasts . Positive_regulation MMP7 RBBP4 12810630 1102803 In this study , we test the possibility that inhibitor may increase RECK expression to *inhibit* [MMP] activation and cancer cell invasion . Positive_regulation MMP7 RBBP7 12810630 1102804 In this study , we test the possibility that inhibitor may increase RECK expression to *inhibit* [MMP] activation and cancer cell invasion . Positive_regulation MMP7 RECK 16103099 1444556 , a glycosylphosphatidylinositol (GPI) anchored glycoprotein , negatively *regulates* [matrix metalloproteinases (MMP)] , such as MMP-9 , and inhibits tumor invasion and metastasis . Positive_regulation MMP7 RECK 18989628 2022052 Concluding , our results provide evidences that and TIMP-2 are *involved* in the control of ECM remodeling in distinct phases of osteoblast differentiation by modulating [MMP] activities and a multitude of signaling proteins governs these events . Positive_regulation MMP7 RELA 16423269 1515352 A specific inhibitor of *reduced* [MMP] production by alveolar macrophages from SP-D-/- mice . Positive_regulation MMP7 RELA 19320561 2162365 Hence , induction of by shear stress *contributes* to [MMP] induction and allows long-term flow induced vascular enlargement . Positive_regulation MMP7 RELA 19639210 2113218 These data suggest that VK2 *inhibits* [MMP] expression by suppressing and MAP kinase activity and might be potentially useful in the treatment of HCC . Positive_regulation MMP7 RENBP 21482542 2448381 *enhanced* expression and enzyme activity of [MMP] and ADAMTS genes and resulted in reduction of collagen II . Positive_regulation MMP7 RETN 21277149 2403325 Furthermore , resistin activated PKCe , but selective PKCe inhibitor suppressed *induced* [MMP] expression , activity , and cell migration . Positive_regulation MMP7 RLN1 15642129 1363079 Previously , we showed that dose-dependently *induces* [matrix metalloproteinase (MMP)] expression in isolated joint fibrocartilaginous cells . Positive_regulation MMP7 RLN1 15956693 1422392 In addition , negatively *regulates* expression of endometrial [matrix metalloproteinases (MMP)] , causing decreased endometrial levels of MMP-1 and MMP-3 proteins and increased protein levels of their endogenous inhibitor , tissue inhibitor of metalloproteinase 1 . Positive_regulation MMP7 RLN1 15956732 1422636 In an in vivo rhesus monkey model of early pregnancy , decreases cervical collagen content , decreases cervical lumican levels , and *stimulates* [MMP-7] levels . Positive_regulation MMP7 RLN1 16709614 1584696 Taken together , this study provides proof-of- principle that gene expression targeted to the mouse lungs can *result* in enhanced [MMP] activity offering potential for alleviating disease conditions characterized by dysregulation of extracellular matrix protein accumulation . Positive_regulation MMP7 RLN1 17920032 1844004 Previous studies have indicated that [MMP] production can be *stimulated* by the hormone . Positive_regulation MMP7 RLN2 15642129 1363080 Previously , we showed that dose-dependently *induces* [matrix metalloproteinase (MMP)] expression in isolated joint fibrocartilaginous cells . Positive_regulation MMP7 RLN2 15956693 1422393 In addition , negatively *regulates* expression of endometrial [matrix metalloproteinases (MMP)] , causing decreased endometrial levels of MMP-1 and MMP-3 proteins and increased protein levels of their endogenous inhibitor , tissue inhibitor of metalloproteinase 1 . Positive_regulation MMP7 RLN2 15956732 1422637 In an in vivo rhesus monkey model of early pregnancy , decreases cervical collagen content , decreases cervical lumican levels , and *stimulates* [MMP-7] levels . Positive_regulation MMP7 RLN2 16709614 1584697 Taken together , this study provides proof-of- principle that gene expression targeted to the mouse lungs can *result* in enhanced [MMP] activity offering potential for alleviating disease conditions characterized by dysregulation of extracellular matrix protein accumulation . Positive_regulation MMP7 RLN2 17920032 1844005 Previous studies have indicated that [MMP] production can be *stimulated* by the hormone . Positive_regulation MMP7 RLN3 15642129 1363081 Previously , we showed that dose-dependently *induces* [matrix metalloproteinase (MMP)] expression in isolated joint fibrocartilaginous cells . Positive_regulation MMP7 RLN3 15956693 1422394 In addition , negatively *regulates* expression of endometrial [matrix metalloproteinases (MMP)] , causing decreased endometrial levels of MMP-1 and MMP-3 proteins and increased protein levels of their endogenous inhibitor , tissue inhibitor of metalloproteinase 1 . Positive_regulation MMP7 RLN3 15956732 1422638 In an in vivo rhesus monkey model of early pregnancy , decreases cervical collagen content , decreases cervical lumican levels , and *stimulates* [MMP-7] levels . Positive_regulation MMP7 RLN3 16709614 1584698 Taken together , this study provides proof-of- principle that gene expression targeted to the mouse lungs can *result* in enhanced [MMP] activity offering potential for alleviating disease conditions characterized by dysregulation of extracellular matrix protein accumulation . Positive_regulation MMP7 RLN3 17920032 1844006 Previous studies have indicated that [MMP] production can be *stimulated* by the hormone . Positive_regulation MMP7 RUNX2 21896846 2491786 DEX reduced total A ( 1 ) AR-triggered [MMP] release , and *increased* the active form of MMP-2 release . Positive_regulation MMP7 S100A9 23135911 2722619 *Induction* of cytokines and [matrix metalloproteases (MMP)] by was markedly downregulated in melanoma cells by attenuation of EMMPRIN . Positive_regulation MMP7 SAA1 22076945 2574698 *increased* MMP-1 , MMP-3 , MMP-13 , and [MMP/TIMP] expression in RA FLS and synovial explants ( P < 0.05 ) . Positive_regulation MMP7 SDC1 18378436 1925492 Our results suggest that and beta1 integrin signaling downstream of AG73 *regulate* adhesion and [MMP] production by CAC2 and M1 cells . Positive_regulation MMP7 SDC2 22227189 2544568 The cell surface heparan sulfate proteoglycan *regulates* the activation of [matrix metalloproteinase-7 (MMP-7)] as a docking receptor . Positive_regulation MMP7 SDS 17222211 1664185 MMP2 and MMP9 mRNA contents were determined by RT-PCR and [MMP] activity by electrophoresis in gelatin containing polyacrylamide gels in the *presence* of under non reducing conditions . Positive_regulation MMP7 SDS 9101722 423078 Truncated fibroblast-type collagenase ( mini-CL ) , truncated stromelysin-1 ( mini-SL-1 ) , and [matrilysin] , like their native counterparts , could be *activated* by organomercurials , trypsin , or . Positive_regulation MMP7 SERPINE1 20820985 2318422 Our results suggest that infection with a virulent H. pylori strain was associated with early-stage gastric cancer and that carcinogenesis was associated with cag *dependent* [MMP-7] upregulation . Positive_regulation MMP7 SERPINE1 22798012 2645694 This effect resulted from the presence of the potent [MMP] *inhibitors* , tissue inhibitor of metalloproteinases-1 ( TIMP-1 ) , type-1 plasminogen activator inhibitor ( ) and thrombospondin-1 (TSP-1) in the amnion dressings , as shown by real-time fluorescence zymography and protein microarrays . Positive_regulation MMP7 SKP1 14981939 1182840 did not *enhance* [MMP] activity in any of the cell lines tested . Positive_regulation MMP7 SLC38A3 20150185 2214734 Modulation of MLK3 , JNK1 , and c-Jun pathways modulated *induced* [matrix metalloproteinase 7] promoter activation . Positive_regulation MMP7 SLC38A3 20637111 2297480 In addition , overexpression of GSK3beta wild type ( WT ) or S9A mutant inhibited *induced* migration and [MMP7] promoter induction . Positive_regulation MMP7 SOD2 12538496 1050111 The *dependent* increases in AP-1 and SP-1 DNA binding activity , MMP-1 promoter activity , general [MMP] expression , and collagen degradation can be reversed by the hydrogen peroxide detoxifying enzyme , catalase . Positive_regulation MMP7 SOX18 22292085 2545865 The *regulates* the expression of [matrix metalloproteinase 7] and guidance molecules in human endothelial cells . Positive_regulation MMP7 SPP1 19010864 1991565 , which *activates* [matrix metalloproteinases (MMP)] , is considered a prognostic biomarker in several cancers . Positive_regulation MMP7 SPP1 19850036 2184229 Through the nuclear import of beta-catenin , *increases* both the transcription and protein levels of [MMP-7] and CD44 , which are known TCF/LEF transcription targets . Positive_regulation MMP7 SRC 12421825 1036422 This resulted from *induced* [MMP] activation , implicated using PP2 ( Src family kinase inhibitor ) or the expression of a dominant negative Src protein . Positive_regulation MMP7 SRC 21505267 2448778 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the and activating transcription factor 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or [Matrix Metalloproteinase (MMP)] . Positive_regulation MMP7 SSFA2 12594231 1060752 Inhibition studies using protein kinase inhibitors ( PD98059 and SB203580 ) showed that those MAPK pathways contributed to [MMP] *up-regulation* by COOH-HBFN-f and . Positive_regulation MMP7 SSFA2 12594231 1060774 Thus , the present results have clearly shown that COOH-HBFN-f and *stimulate* [MMP] production in association with activation of MAPK pathways in RSF . Positive_regulation MMP7 STAT3 16494848 1528734 Instead , we show that overexpression of a dominant negative mutant *reduces* FGF-2 mediated [MMP7] promoter activity . Positive_regulation MMP7 STAT3 16494848 1528737 However , does not bind to the MMP7 promoter , but *activates* [MMP7] gene expression indirectly via AP-1 . Positive_regulation MMP7 STAT3 18411043 1907777 HER2 dependent [MMP-7] expression is *mediated* by activated . Positive_regulation MMP7 TAT 22419111 2572706 The anion-channel inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid ( DIDS ) protects isolated mitochondria against *induced* mitochondrial [membrane permeabilization (MMP)] , whereas ruthenium red , a ryanodine receptor blocker , does not . Positive_regulation MMP7 TAT 22419111 2572769 Pharmacologic inhibitors of the permeability transition pore , Bax/Bak inhibitors , and recombinant Bcl-2 and Bcl-XL proteins do not reduce *induced* [MMP] . Positive_regulation MMP7 TBX22 12756268 1090714 Bax-/- Bak-/- double knockout cells fail to undergo [MMP] and cell death in *response* to or NFX induced LMP . Positive_regulation MMP7 TCF12 22232518 2569249 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of [MMP7] promoter by WNT7A was *mediated* by <ß-catenin/TCF> signaling . Positive_regulation MMP7 TCF15 22232518 2569250 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of [MMP7] promoter by WNT7A was *mediated* by <ß-catenin/TCF> signaling . Positive_regulation MMP7 TCF19 22232518 2569251 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of [MMP7] promoter by WNT7A was *mediated* by <ß-catenin/TCF> signaling . Positive_regulation MMP7 TCF20 22232518 2569252 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of [MMP7] promoter by WNT7A was *mediated* by <ß-catenin/TCF> signaling . Positive_regulation MMP7 TCF21 22232518 2569253 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of [MMP7] promoter by WNT7A was *mediated* by <ß-catenin/TCF> signaling . Positive_regulation MMP7 TCF23 22232518 2569258 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of [MMP7] promoter by WNT7A was *mediated* by <ß-catenin/TCF> signaling . Positive_regulation MMP7 TCF24 22232518 2569260 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of [MMP7] promoter by WNT7A was *mediated* by <ß-catenin/TCF> signaling . Positive_regulation MMP7 TCF25 22232518 2569259 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of [MMP7] promoter by WNT7A was *mediated* by <ß-catenin/TCF> signaling . Positive_regulation MMP7 TCF3 15669012 1382135 Luciferase experiments indeed showed that as well as VP16-CIZ *transactivates* the [MMP7] promoter . Positive_regulation MMP7 TCF3 22232518 2569254 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of [MMP7] promoter by WNT7A was *mediated* by <ß-catenin/TCF> signaling . Positive_regulation MMP7 TCF4 22232518 2569255 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of [MMP7] promoter by WNT7A was *mediated* by <ß-catenin/TCF> signaling . Positive_regulation MMP7 TCF7 22232518 2569256 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of [MMP7] promoter by WNT7A was *mediated* by <ß-catenin/TCF> signaling . Positive_regulation MMP7 TERT 23884427 2861396 Human *regulates* [MMP] expression independently of telomerase activity via NF-?B dependent transcription . Positive_regulation MMP7 TGFB1 10508223 649882 The objective of the present study was to determine whether ( TGF-beta ) *regulates* the expression of [matrix metalloproteinases (MMP)] and the tissue inhibitor of MMP (TIMP) in myometrial smooth muscle cells . Positive_regulation MMP7 TGFB1 10508223 649981 In conclusion , the data indicate that myometrial smooth muscle cells express [MMP] and TIMP mRNA and protein , and their expression is differentially *regulated* by . Positive_regulation MMP7 TGFB1 10633007 576612 In conclusion , these results indicate that mesothelial cells express [MMP] and TIMP mRNA and protein , and their expression is differentially *regulated* by , a mechanism that in part may influence the outcome of peritoneal tissue repair and adhesion formation . Positive_regulation MMP7 TGFB1 11192834 761578 It is known that platelet derived growth factor ( PDGF ) and ( TGF-beta ) are *involved* in the regulation of [MMP] activity and tissue inhibitor of metalloproteinase ( TIMP ) production in non-ocular tissues . Positive_regulation MMP7 TGFB1 15194465 1259966 We demonstrate that *induces* [MMP-activity] in CFBs , thereby facilitating CFBs motility . Positive_regulation MMP7 TGFB1 15247230 1289674 Because transforming growth factor-beta1 ( TGF-beta1 ) promotes tumor invasion in advanced squamous cell carcinomas , the *role* of in the regulation of [MMP] activity in a cellular model of invasive oral squamous cell carcinoma was examined . Positive_regulation MMP7 TGFB1 15780084 1385278 These responses which are dependent on its protease activity appear not to be mediated by PAR-1 activation , the autocrine action of thrombin induced secretion , [MMP] *activation* , or EGF receptor transactivation . Positive_regulation MMP7 TGFB1 18505915 1917919 When cancer cells were cultured on plastic , , TGF-beta2 , and TGF-beta3 *induced* [pro-matrix metalloproteinase (MMP)] secretion , loss of cell-cell junctions , down-regulation of E-cadherin , up-regulation of N-cadherin , and acquisition of a fibroblastoid phenotype , consistent with an epithelial-to-mesenchymal transition . Positive_regulation MMP7 TGFB1 19543300 2103820 Moreover , MS80 arrested *induced* human embryo pulmonary fibroblast ( HEPF ) cell proliferation , collagen deposition and [matrix metalloproteinase (MMP)] activity . Positive_regulation MMP7 TGFB1 20648565 2363159 Our results further suggest that EMMPRIN regulates differentiation through an [MMP] *activation* of ( TGFß ) , a known inhibitor of myoblast 's differentiation , as the increased activation and signaling of TGFß by EMMPRIN was attenuated in the presence of marimastat . Positive_regulation MMP7 TGFB2 10508223 649883 The objective of the present study was to determine whether ( TGF-beta ) *regulates* the expression of [matrix metalloproteinases (MMP)] and the tissue inhibitor of MMP (TIMP) in myometrial smooth muscle cells . Positive_regulation MMP7 TGFB2 11192834 761579 It is known that platelet derived growth factor ( PDGF ) and ( TGF-beta ) are *involved* in the regulation of [MMP] activity and tissue inhibitor of metalloproteinase ( TIMP ) production in non-ocular tissues . Positive_regulation MMP7 TGFB2 18505915 1917920 When cancer cells were cultured on plastic , TGF-beta1 , , and TGF-beta3 *induced* [pro-matrix metalloproteinase (MMP)] secretion , loss of cell-cell junctions , down-regulation of E-cadherin , up-regulation of N-cadherin , and acquisition of a fibroblastoid phenotype , consistent with an epithelial-to-mesenchymal transition . Positive_regulation MMP7 TGFB2 20648565 2363160 Our results further suggest that EMMPRIN regulates differentiation through an [MMP] *activation* of ( TGFß ) , a known inhibitor of myoblast 's differentiation , as the increased activation and signaling of TGFß by EMMPRIN was attenuated in the presence of marimastat . Positive_regulation MMP7 TGFB3 10508223 649884 The objective of the present study was to determine whether ( TGF-beta ) *regulates* the expression of [matrix metalloproteinases (MMP)] and the tissue inhibitor of MMP (TIMP) in myometrial smooth muscle cells . Positive_regulation MMP7 TGFB3 11192834 761580 It is known that platelet derived growth factor ( PDGF ) and ( TGF-beta ) are *involved* in the regulation of [MMP] activity and tissue inhibitor of metalloproteinase ( TIMP ) production in non-ocular tissues . Positive_regulation MMP7 TGFB3 18505915 1917921 When cancer cells were cultured on plastic , TGF-beta1 , TGF-beta2 , and *induced* [pro-matrix metalloproteinase (MMP)] secretion , loss of cell-cell junctions , down-regulation of E-cadherin , up-regulation of N-cadherin , and acquisition of a fibroblastoid phenotype , consistent with an epithelial-to-mesenchymal transition . Positive_regulation MMP7 TGFB3 18505915 1917947 When cancer cells were cultured on a three-dimensional collagen matrix , TGF-beta1 , TGF-beta2 , and *stimulated* both [pro-MMP] and active MMP secretion and invasion . Positive_regulation MMP7 TGFB3 20304269 2230562 When both the LE and perichondrium are disrupted , [matrix metalloproteinase (MMP)] levels within adjacent chondrocytes are diminished but can be *restored* by exogenous . Positive_regulation MMP7 TGFB3 20648565 2363161 Our results further suggest that EMMPRIN regulates differentiation through an [MMP] *activation* of ( TGFß ) , a known inhibitor of myoblast 's differentiation , as the increased activation and signaling of TGFß by EMMPRIN was attenuated in the presence of marimastat . Positive_regulation MMP7 TGFBI 17327467 1706642 By overexpressing betaig-h3 in human SMMC-7721 hepatoma cells , we discovered that *promoted* cell adhesion , invasion , and [matrix metalloproteinase (MMP)] secretion potential . Positive_regulation MMP7 TGM2 24130925 2714732 Gene silencing of *suppressed* the [MMP] expression by ATRA . Positive_regulation MMP7 THBS1 10900205 736963 Tissue culture and in vitro assays demonstrated that the presence of purified TSR and intact *resulted* in inhibition of [MMP] activity . Positive_regulation MMP7 THBS2 21479427 2009796 In this study , we examined the *role* of in tumor cell invasion and its association with proteolytic proteins , [matrix metalloproteinase (MMP)] and the plasminogen/plasmin system , including urokinase-type plasminogen activator ( uPA ) , in the human pancreatic cancer cell line PANC-1 . Positive_regulation MMP7 TIMP1 10219984 609136 [MMP] activities are precisely *regulated* by endogenous . Positive_regulation MMP7 TIMP1 11960708 932466 We examined the expression patterns of two [MMP] *inhibitors* , tissue inhibitor of metalloproteinase ( ) -2 and TIMP-3 , during critical stages of cardiac development . Positive_regulation MMP7 TIMP1 18385523 1899230 Our data demonstrate that interacts with matrix metalloproteinases and *regulates* [matrilysin] activity during airway epithelial repair . Positive_regulation MMP7 TIMP1 20665704 2363226 Thus , MSCs are revealed as robust sources of *mediated* [MMP-inhibition] , capable of protecting the perivascular niche from high levels of MMPs even under pathological conditions . Positive_regulation MMP7 TIMP1 21362377 2399823 Tissue inhibitor of metalloproteinase-1 ( ) *inhibits* [matrix metalloproteinase (MMP)] activity and regulates proliferation and apoptosis of a variety of cell types , including pancreatic ß-cells . Positive_regulation MMP7 TIMP1 23631818 2790682 Furthermore , siRNA depletion of or TIMP-2 *prevented* IR-mediated induction of [MMP] activity and cell invasion . Positive_regulation MMP7 TIMP1 7790389 313233 Therefore , the mechanistic aspects of TIMP-1 regulation by retinoic acid in primary cultures of rat calvarial bone cell populations were studied and compared with those of TGF-beta 1 to determine if modulation of would *augment* [MMP] expression . Positive_regulation MMP7 TIMP1 8219937 231841 It is suggested that *contributes* to the regulation of [MMP-activity] involved in the remodeling and turnover of bone . Positive_regulation MMP7 TIMP1 9573338 502444 Enzyme activity of [MMP-C31] and -H19 was *inhibited* by human , TIMP-2 and synthetic MMP inhibitors , BB94 and CT543 , indicating that the catalytic sites of these C. elegans MMPs are structurally closely related with those of mammalian MMPs . Positive_regulation MMP7 TIMP2 15546163 1374880 As expected , overexpression of *inhibited* [matrix metalloprotenase (MMP)] activity and invasion of the tumor cells . Positive_regulation MMP7 TIMP2 15920147 1413586 Reverse transcriptase-polymerase chain reaction demonstrated that increased [MMP] activity was due , at least in part , to increased transcription and that transcripts *increased* in embolic myxomas . Positive_regulation MMP7 TIMP2 18723334 1984966 In contrast , fibroblasts in areas of parenchymal destruction of emphysema/UIP expressed MMP-2 , MMP-9 , [MMP-7] and MT1-MMP at variable but significantly higher levels when compared to emphysema subjects , in the *presence* of similar levels of TIMP-1 , and TNF-alpha . Positive_regulation MMP7 TIMP2 18989628 2022053 Concluding , our results provide evidences that RECK and are *involved* in the control of ECM remodeling in distinct phases of osteoblast differentiation by modulating [MMP] activities and a multitude of signaling proteins governs these events . Positive_regulation MMP7 TIMP2 23631818 2790683 Furthermore , siRNA depletion of TIMP-1 or *prevented* IR-mediated induction of [MMP] activity and cell invasion . Positive_regulation MMP7 TIMP2 24418973 2942434 We determined the level of the ECM proteases urokinase-like plasminogen activator ( uPA ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous [MMP] *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and in the conditioned media . Positive_regulation MMP7 TIMP2 9573338 502445 Enzyme activity of [MMP-C31] and -H19 was *inhibited* by human tissue inhibitor of MMPs (TIMP)-1 , and synthetic MMP inhibitors , BB94 and CT543 , indicating that the catalytic sites of these C. elegans MMPs are structurally closely related with those of mammalian MMPs . Positive_regulation MMP7 TIMP3 10645926 661832 Tissue *inhibitor* of metalloproteinase-3 ( ) , an extracellular matrix associated [MMP] inhibitor , uniquely promotes apoptosis of isolated vascular smooth muscle cells . Positive_regulation MMP7 TIMP3 17327279 1706578 Recombinant and synthetic metalloproteinase inhibitors reverted the increase in dephosphorylated beta-catenin , decrease in Ccnd1 gene expression and *increase* in [Mmp7] gene expression . Positive_regulation MMP7 TLR1 18802113 1964821 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP7 TLR10 18802113 1964829 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP7 TLR2 18802113 1964822 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP7 TLR2 21464389 2417486 Angiotensin II type 1 receptor antagonism appears to inhibit intimal neovascularization in ApoE ( -/- ) mice , partly by reducing mediated inflammatory action and [MMP] *activation* , thus decreasing atherosclerotic plaque growth and increasing plaque instability . Positive_regulation MMP7 TLR3 18802113 1964823 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP7 TLR4 18802113 1964824 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP7 TLR4 21464389 2417487 Angiotensin II type 1 receptor antagonism appears to inhibit intimal neovascularization in ApoE ( -/- ) mice , partly by reducing mediated inflammatory action and [MMP] *activation* , thus decreasing atherosclerotic plaque growth and increasing plaque instability . Positive_regulation MMP7 TLR5 18802113 1964825 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP7 TLR6 18802113 1964830 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP7 TLR7 18802113 1964826 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP7 TLR8 18802113 1964827 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP7 TLR9 18802113 1964828 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP7 TM4SF5 20506553 2307999 We found that TM4SF5 expression facilitated migration , invadopodia formation , [MMP] activation , invasion , and eventually lung metastasis in nude mice , but suppression of with its shRNA *blocked* the effects . Positive_regulation MMP7 TMEM14A 21723035 2461061 *prevented* 4-HPR induced loss of mitochondrial [membrane potential (MMP)] , the release of cytochrome c , and the activation of caspase-3 , but not the generation of reactive oxygen species , suggesting that TMEM14A regulates mitochondrial membrane potential in a ROS independent manner . Positive_regulation MMP7 TMEM14A 21723035 2461107 Suppression of expression using shRNA significantly *increased* apoptosis and [MMP] loss in untreated and 4-HPR treated cells . Positive_regulation MMP7 TMSB4X 16607611 1550835 Because proteinases are important in wound repair , we hypothesized that may *regulate* [matrix metalloproteinase (MMP)] expression in cells that are involved in wound repair . Positive_regulation MMP7 TNC 15178565 1280454 Together with our previous observations , our data suggest that *upregulates* [MMP] expression that cleaves Tn-C into fragments containing the EGF-like domain . Positive_regulation MMP7 TNF 10482270 643788 We also examined the possibility that such MMPs could be produced by brain derived cells , and that [MMP] production by these cells might be *increased* by , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD . Positive_regulation MMP7 TNF 10864917 705854 IL-1beta and each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP7 TNF 11147175 760934 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that may *induce* [MMP] production followed by matrix degradation within foreign body granulomas . Positive_regulation MMP7 TNF 11773040 899411 Isolated RMVECs did not significantly increase [MMP] production directly in response to a hypoxic stimulus , but *required* the presence of exogenous . Positive_regulation MMP7 TNF 12113550 963875 Because elevation of COX-2 mRNA levels enhances the production of prostaglandins , we therefore investigated whether endogenous prostaglandins are involved in the [MMP] mRNA expression that is *enhanced* by . Positive_regulation MMP7 TNF 12606436 1064591 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP7 TNF 12909329 1121959 *mediates* the stretch induced [MMP] genes expression , at least in part , through the JNK pathway . Positive_regulation MMP7 TNF 14673992 1178650 The in vivo data clearly indicated that OSM + overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP7 TNF 15044327 1272769 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to dependent [MMP] *induction* in the macrophages . Positive_regulation MMP7 TNF 15184206 1280585 *causes* increased [MMP] production , but some increased MMP activity is present even in TNFRKO mice . Positive_regulation MMP7 TNF 15201935 1260874 IL-1 and are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP7 TNF 15545168 1337806 [Matrilysin-1] was *up-regulated* by and IL-1 beta , and stromelysin-2 by TNF-alpha and EGF in Caco-2 and WiDr cell cultures . Positive_regulation MMP7 TNF 16549372 1582264 and OSM induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP7 TNF 17062332 1637235 To investigate the regulatory effects of fenofibrate on *induced* CD40 expression and [matrix metalloproteinase (MMP)] activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation MMP7 TNF 17469134 1737540 OSM and *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP7 TNF 17507431 1791869 Moreover , [MMP] activity in PCPEC supernatants was significantly *increased* by , presumably due to a diminished expression of TIMP-3 that was similarly observed . Positive_regulation MMP7 TNF 17678632 1781205 Pretreatment of human intestinal epithelial HT-29 cells with TMMC also significantly inhibited the IL-8 and extracellular [matrix metalloproteinase-7] levels *induced* by . Positive_regulation MMP7 TNF 17876544 1796356 A similar augmentation was also observed in *induced* cytokine and [MMP] secretion . Positive_regulation MMP7 TNF 18252806 1895829 TNF-alpha *induces* the expression of transcripts for inflammatory mediators interleukin (IL)-6 , IL-8 , regulated on activation normal T cell expressed and secreted , , granulocyte macrophage-colony stimulating factor ( GM-CSF ) , and monocyte chemoattractant protein (MCP)-1 and also invasion mediators [matrix metalloproteinase (MMP)-7] , MMP-9 , and intracellular adhesion molecule-1 . Positive_regulation MMP7 TNF 18723334 1984967 In contrast , fibroblasts in areas of parenchymal destruction of emphysema/UIP expressed MMP-2 , MMP-9 , [MMP-7] and MT1-MMP at variable but significantly higher levels when compared to emphysema subjects , in the *presence* of similar levels of TIMP-1 , TIMP-2 and . Positive_regulation MMP7 TNF 19026560 2001520 suppressed collagen type II and aggrecan , but *increased* [MMP] and cytokine expression in chondrocytes compared to the non stimulated controls . Positive_regulation MMP7 TNF 19435506 2106983 does not *induce* [MMP] expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation MMP7 TNF 20007453 2210598 We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since *induced* superoxide production , [MMP] expression , and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma . Positive_regulation MMP7 TNF 20403361 2267437 While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha , however , [matrix metalloproteinase (MMP)] *activation* of may also be contributory . Positive_regulation MMP7 TNF 20655064 2424547 *up-regulated* [MMP-7] in non wounded and wounded cells , and IFN-? did not affect its expression . Positive_regulation MMP7 TNF 23417988 2843316 SUMO-2/3 was knocked down using small interfering RNA in SFs , and *induced* [MMP] production was determined by ELISA . Positive_regulation MMP7 TNF 23417988 2843349 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by TNF-a and selectively control *mediated* [MMP] expression via the NF-?B pathway . Positive_regulation MMP7 TNF 23603294 2795192 Furthermore , infliximab effectively attenuated the *induced* increases in [MMP] expression in cells that make up the BAB . Positive_regulation MMP7 TNF 7543547 314353 Northern hybridization assays showed pretranslational control of PMA- , basic fibroblast growth factor- , and *induced* [MMP] expression . Positive_regulation MMP7 TNF 9014820 405423 In support of this result , stimulation *induced* membrane-type matrix metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation MMP7 TNF 9558121 500107 Recombinant and IL-1beta added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP7 TNF 9631748 512575 *increased* the total [MMP] activity released . Positive_regulation MMP7 TNF 9927150 588424 In general , *stimulated* both [MMP] and TIMP expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation MMP7 TNF 9933437 589411 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by IL-1beta and or down-regulated by IFN-gamma . Positive_regulation MMP7 TNFSF10 18397859 1893687 The purpose of this study was to find out if could *induce* the expression of uPA , IL-8 , [MMP-7] and MMP-9 .and to explore the corresponding potential signaling transduction pathway in pancreatic cancer cells . Positive_regulation MMP7 TNFSF10 18397859 1893689 can *stimulate* the expression of uPA , IL-8 , [MMP-7] and MMP-9 in pancreatic cancer cell lines , especially in Colo357wt . Positive_regulation MMP7 TNFSF10 18397859 1893692 The members of caspases , MEK1/2 , PKC , and NF-kappaB are involved in *induced* expression of uPA , IL-8 , [MMP-7] and MMP-9 . Positive_regulation MMP7 TSR1 10900205 736966 Tissue culture and in vitro assays demonstrated that the presence of purified and intact TSP1 *resulted* in inhibition of [MMP] activity . Positive_regulation MMP7 TSR2 10900205 736965 Tissue culture and in vitro assays demonstrated that the presence of purified and intact TSP1 *resulted* in inhibition of [MMP] activity . Positive_regulation MMP7 TSR3 10900205 736964 Tissue culture and in vitro assays demonstrated that the presence of purified and intact TSP1 *resulted* in inhibition of [MMP] activity . Positive_regulation MMP7 UMOD 22031601 2547568 Both oxLDL and *increased* [matrix metalloproteinase (MMP)] activity in CVC . Positive_regulation MMP7 VEGFA 10999847 734380 Because of reports that can *enhance* [MMP] expression , we hypothesize that VEGF-KDR interactions may influence MMP expression in the superficial zones of the primate endometrium during the premenstrual phase , and that these interactions play a role in the induction of menstruation . Positive_regulation MMP7 VEGFA 15523695 1359888 We report that the secretion of [MMP-7] in EOC is *stimulated* significantly by ( VEGF ) and interlukin-8 (IL-8) . Positive_regulation MMP7 VEGFA 15604273 1346933 First , TIMP-2 can inhibit cell migration after VEGF stimulation by direct inhibition of [MMP] activity induced in *response* to stimulation . Positive_regulation MMP7 VEGFA 16043845 1437886 [MMP] *induction* by was performed in baby hamster kidney ( BHK ) cells . Positive_regulation MMP7 VEGFA 18093986 1889736 Inhibition of VEGFR2 and [ by soluble FMS-like tyrosine kinase-1 ( sFlt1 ) ] *down-regulated* visfatin induced [MMP] induction . Positive_regulation MMP7 VEGFA 19023093 2022675 Therefore , GIT1 mediates induced [matrix metalloproteinase (MMP)] *activation* and ECM degradation by regulating podosome formation . Positive_regulation MMP7 VIPR1 9629281 512238 In contrast , fails to transduce T-cell chemotaxis but *mediates* suppression of chemotaxis and [MMP] expression elicited by some cytokines and chemokines . Positive_regulation MMP7 WASF1 14536061 1152562 WAVE1 is colocalized with ECM degrading enzyme MMP-2 in dorsal ruffles , and , but not WAVE2- , dependent migration *requires* [MMP] activity . Positive_regulation MMP7 WASF2 14536061 1152563 WAVE1 is colocalized with ECM degrading enzyme MMP-2 in dorsal ruffles , and WAVE1- , but not , dependent migration *requires* [MMP] activity . Positive_regulation MMP7 WDR61 23911909 2840392 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Positive_regulation MMP7 WNT1 20677010 2311818 Here , we report that hepatocyte growth factor (HGF) induced E-cadherin downregulation and cell scattering are attributed to the activation of signaling and transcriptional *activation* of matrix metalloproteinase [MMP-7] . Positive_regulation MMP7 WNT1 22095947 2548299 Activation of ß-catenin through ectopic expression of *promoted* [MMP-7] expression in vivo , whereas delivery of the gene encoding the endogenous Wnt antagonist Dickkopf-1 abolished its induction . Positive_regulation MMP7 WNT1 22328140 2630013 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Positive_regulation MMP7 WNT11 20677010 2311819 Here , we report that hepatocyte growth factor (HGF) induced E-cadherin downregulation and cell scattering are attributed to the activation of signaling and transcriptional *activation* of matrix metalloproteinase [MMP-7] . Positive_regulation MMP7 WNT11 22328140 2630014 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Positive_regulation MMP7 WNT16 20677010 2311824 Here , we report that hepatocyte growth factor (HGF) induced E-cadherin downregulation and cell scattering are attributed to the activation of signaling and transcriptional *activation* of matrix metalloproteinase [MMP-7] . Positive_regulation MMP7 WNT16 22328140 2630019 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Positive_regulation MMP7 WNT2 20677010 2311820 Here , we report that hepatocyte growth factor (HGF) induced E-cadherin downregulation and cell scattering are attributed to the activation of signaling and transcriptional *activation* of matrix metalloproteinase [MMP-7] . Positive_regulation MMP7 WNT2 22328140 2630015 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Positive_regulation MMP7 WNT3 20677010 2311821 Here , we report that hepatocyte growth factor (HGF) induced E-cadherin downregulation and cell scattering are attributed to the activation of signaling and transcriptional *activation* of matrix metalloproteinase [MMP-7] . Positive_regulation MMP7 WNT3 22328140 2630016 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Positive_regulation MMP7 WNT4 20677010 2311822 Here , we report that hepatocyte growth factor (HGF) induced E-cadherin downregulation and cell scattering are attributed to the activation of signaling and transcriptional *activation* of matrix metalloproteinase [MMP-7] . Positive_regulation MMP7 WNT4 22328140 2630017 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Positive_regulation MMP7 WNT5A 21035559 2370186 We have previously reported that interleukin-1ß (IL-1ß) up-regulates the expression of Wnt-5A and the activation of signaling *induces* [matrix metalloproteinase (MMP)] through the c-Jun N-terminal kinase pathway in condylar chondrocytes (CCs) of the temporomandibular joint ( TMJ ) . Positive_regulation MMP7 WNT6 20677010 2311823 Here , we report that hepatocyte growth factor (HGF) induced E-cadherin downregulation and cell scattering are attributed to the activation of signaling and transcriptional *activation* of matrix metalloproteinase [MMP-7] . Positive_regulation MMP7 WNT6 22328140 2630018 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Positive_regulation MMP7 WNT7A 22232518 2569257 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that *activation* of [MMP7] promoter by was mediated by ß-catenin/TCF signaling . Positive_regulation MMP7 ZNF746 24145959 2889503 Quantitative PCR ( qPCR ) analysis revealed that the silencing of *attenuated* the expression of matrix metalloproteinase (MMP)1 , MMP2 and MMP9 , but not [MMP7] , in H460 NSCLC cells . Positive_regulation MMP8 CAPN8 21911754 2497132 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP8 CAPN8 21964156 2525910 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP8 CAPN8 22316244 2553416 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP8 CTGF 18632843 1979325 In conclusion , upregulation of inhibits BMP-7 signal transduction in the diabetic kidney and *contributes* to altered gene transcription , reduced [MMP] activity , glomerular basement membrane thickening , and albuminuria , all of which are hallmarks of diabetic nephropathy . Positive_regulation MMP8 EPHB2 14709335 1196666 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP8 EPHB2 20843518 2353074 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and *dependent* [MMP] expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation MMP8 EPHB2 24012928 2862361 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an [MMP] *inhibitor* , or PD98059 ( 50 µM ) , an inhibitor , also suppressed it . Positive_regulation MMP8 IGFBP1 15590975 1346163 Cell numbers were increased only by 100 nM IGFBP-1 isoforms ( P < 0.05 ) , whereas [MMP] levels released from term cells were optimally *increased* by 1-10 nM . Positive_regulation MMP8 IL1B 10727770 678133 and TPA alone *induced* [MMP] activity in HIG-82 cells . Positive_regulation MMP8 IL1B 10864917 705857 and TNF-alpha each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP8 IL1B 10895370 711616 In support of this result , stimulation *induced* the expression of membrane type matrix-metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation MMP8 IL1B 11327259 807608 A decrease in IL-1alpha , , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP8 IL1B 11467889 840807 In all cases , PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on *induction* of [MMP] expression . Positive_regulation MMP8 IL1B 11997239 939306 produced a dose dependent *increase* in [MMP] activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min . Positive_regulation MMP8 IL1B 14602136 1161647 The data indicate that [MMP-8] overexpression in OVCAs is *regulated* by and that pro-inflammatory cytokines may promote the invasive potential of ovarian cancer . Positive_regulation MMP8 IL1B 14872494 1208460 Preincubation with anti-CD44 antibody , which suppressed IL-1beta stimulated MMPs , reversed the inhibitory effect of HA on [MMP] production that was *induced* by in normal and OA cartilage . Positive_regulation MMP8 IL1B 16449361 1573885 HA at > or =2 mg/ml significantly inhibited [MMP] production *induced* by in a dose dependent manner . Positive_regulation MMP8 IL1B 16449361 1573907 Inhibition studies revealed the requirement of NF-kappaB , p38 and c-jun NH2-terminal kinase ( JNK ) for *induced* [MMP] production . Positive_regulation MMP8 IL1B 17328062 1711908 SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on *stimulated* [MMP] production and collagen degradation . Positive_regulation MMP8 IL1B 17925024 1835443 These findings demonstrate , for the first time , that glucosamine inhibits *stimulated* [MMP] production in human chondrocytes by affecting MAPK phosphorylation . Positive_regulation MMP8 IL1B 18403593 1899540 DHA significantly decreased VSMC migration/proliferation *induced* by as well as [fibrinolytic/MMP] activity . Positive_regulation MMP8 IL1B 18535174 1928807 *stimulated* [MMP] mRNA synthesis in wild-type , but not in IL-1RI-null cardiac fibroblasts . Positive_regulation MMP8 IL1B 19056796 2017724 Cordycepin is a potent inhibitor of *induced* chemokine production and [MMP] expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs . Positive_regulation MMP8 IL1B 19542681 2099207 *induced* [MMP] production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ) , p38 kinase , and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase (MAPK) family signal transduction molecules . Positive_regulation MMP8 IL1B 20403707 2282295 *induced* [MMP] production was significantly augmented in the presence of sIL-6R . Positive_regulation MMP8 IL1B 21344389 2480451 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Positive_regulation MMP8 IL1B 22792188 2628392 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation MMP8 IL1B 8569187 349844 Chondrocyte matrix metalloproteinase-8 : *up-regulation* of [neutrophil collagenase] by in human cartilage from knee and ankle joints . Positive_regulation MMP8 IL1B 9558121 500110 Recombinant TNF-alpha and added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP8 IL1B 9821179 548129 The inflammatory cytokine did not *induce* [MMP] or TIMP expression . Positive_regulation MMP8 IL1B 9890433 585426 A beta , but not or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells , as well as *increased* the expression of the well-known activator of MMP-2 , membrane-type ( MT ) [-MMP] . Positive_regulation MMP8 IL1B 9933437 589414 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by and TNF-alpha or down-regulated by IFN-gamma . Positive_regulation MMP8 MAP2K6 19833163 2196202 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP8 MAP2K6 20545600 2308496 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP8 MAP2K6 22310287 2719030 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP8 MMP7 16574944 1598095 No increases in RNA levels of MMP-2 , MMP-9 , or [MMP-8] were found , but levels of , MMP-12 , and MMP-13 RNA did *increase* at 14 d . Positive_regulation MMP8 MMP7 17017992 1630082 *activates* [MMP-8] but not MMP-13 . Positive_regulation MMP8 MMP7 17017992 1630084 Whether the additional collagenases , [MMP-8] and MMP-13 , are also *activated* by has not been explored . Positive_regulation MMP8 PODXL 17616675 1769343 These findings suggest that leads to increased in vitro migration and invasion , *increased* [MMP] expression , and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MMP8 TGM2 24130925 2714733 Gene silencing of *suppressed* the [MMP] expression by ATRA . Positive_regulation MMP8 TLR7 18802113 1964836 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP8 TNF 10482270 643789 We also examined the possibility that such MMPs could be produced by brain derived cells , and that [MMP] production by these cells might be *increased* by , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD . Positive_regulation MMP8 TNF 10864917 705856 IL-1beta and each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP8 TNF 11147175 760935 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that may *induce* [MMP] production followed by matrix degradation within foreign body granulomas . Positive_regulation MMP8 TNF 11773040 899412 Isolated RMVECs did not significantly increase [MMP] production directly in response to a hypoxic stimulus , but *required* the presence of exogenous . Positive_regulation MMP8 TNF 12113550 963876 Because elevation of COX-2 mRNA levels enhances the production of prostaglandins , we therefore investigated whether endogenous prostaglandins are involved in the [MMP] mRNA expression that is *enhanced* by . Positive_regulation MMP8 TNF 12606436 1064593 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP8 TNF 12909329 1121960 *mediates* the stretch induced [MMP] genes expression , at least in part , through the JNK pathway . Positive_regulation MMP8 TNF 14673992 1178652 The in vivo data clearly indicated that OSM + overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP8 TNF 15044327 1272770 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to dependent [MMP] *induction* in the macrophages . Positive_regulation MMP8 TNF 15184206 1280586 *causes* increased [MMP] production , but some increased MMP activity is present even in TNFRKO mice . Positive_regulation MMP8 TNF 15201935 1260876 IL-1 and are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP8 TNF 16549372 1582266 and OSM induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP8 TNF 17062332 1637236 To investigate the regulatory effects of fenofibrate on *induced* CD40 expression and [matrix metalloproteinase (MMP)] activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation MMP8 TNF 17469134 1737542 OSM and *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP8 TNF 17507431 1791870 Moreover , [MMP] activity in PCPEC supernatants was significantly *increased* by , presumably due to a diminished expression of TIMP-3 that was similarly observed . Positive_regulation MMP8 TNF 17876544 1796357 A similar augmentation was also observed in *induced* cytokine and [MMP] secretion . Positive_regulation MMP8 TNF 19026560 2001521 suppressed collagen type II and aggrecan , but *increased* [MMP] and cytokine expression in chondrocytes compared to the non stimulated controls . Positive_regulation MMP8 TNF 19435506 2106984 does not *induce* [MMP] expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation MMP8 TNF 20007453 2210599 We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since *induced* superoxide production , [MMP] expression , and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma . Positive_regulation MMP8 TNF 20403361 2267438 While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha , however , [matrix metalloproteinase (MMP)] *activation* of may also be contributory . Positive_regulation MMP8 TNF 23417988 2843317 SUMO-2/3 was knocked down using small interfering RNA in SFs , and *induced* [MMP] production was determined by ELISA . Positive_regulation MMP8 TNF 23417988 2843350 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by TNF-a and selectively control *mediated* [MMP] expression via the NF-?B pathway . Positive_regulation MMP8 TNF 23603294 2795193 Furthermore , infliximab effectively attenuated the *induced* increases in [MMP] expression in cells that make up the BAB . Positive_regulation MMP8 TNF 7543547 314354 Northern hybridization assays showed pretranslational control of PMA- , basic fibroblast growth factor- , and *induced* [MMP] expression . Positive_regulation MMP8 TNF 9014820 405424 In support of this result , stimulation *induced* membrane-type matrix metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation MMP8 TNF 9558121 500109 Recombinant and IL-1beta added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP8 TNF 9631748 512576 *increased* the total [MMP] activity released . Positive_regulation MMP8 TNF 9927150 588425 In general , *stimulated* both [MMP] and TIMP expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation MMP8 TNF 9933437 589413 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by IL-1beta and or down-regulated by IFN-gamma . Positive_regulation MMP9 ALOX5 20153347 2248522 Episodic exposure to acrolein-rich pollutants has been linked to acute myocardial infarction , and <5-lipoxygenase (5-LO)> is *involved* in the production of [matrix metalloproteinase-9 (MMP-9)] , which destabilizes atherosclerotic plaques . Positive_regulation MMP9 ALOX5 22253131 2600000 Transfection of into a PTC cell line ( BCPAP ) *increased* [MMP-9] secretion and cell invasion across an ECM barrier . Positive_regulation MMP9 ANGPT1 14615417 1163792 interactions *regulate* [mmp-9] expression and retinal neovascularization . Positive_regulation MMP9 ANGPT1 14615417 1163801 The stimulation of cultured retinal endothelial cells with and -2 *resulted* in the increased expression of [matrix metalloproteinase (MMP)-9] . Positive_regulation MMP9 CAPN8 15955824 1440719 Cell-permeable inhibitors , including calpastatin and calpeptin , were *sufficient* to suppress RANKL supported osteoclastogenesis based on decreased expression of the osteoclastogenic marker , [matrix metalloproteinase 9] , and the generation of tartrate-resistant acid phosphatase positive multinucleated cells in both cell types . Positive_regulation MMP9 CAPN8 16877562 1638712 Homocysteine mediated activation and mitochondrial translocation of *regulates* [MMP-9] in MVEC . Positive_regulation MMP9 CAPN8 16877562 1638740 Our observations suggested that *regulates* Hcy induced [MMP-9] expression and activity . Positive_regulation MMP9 CAPN8 16877562 1638768 Furthermore , studies with pharmacological inhibitors of calpain ( calpeptin and calpain-1 inhibitor ) , ERK ( PD-98059 ) and the mitochondrial uncoupler FCCP suggested that and ERK-1/2 are the major events within the Hcy/MMP-9 signal axis and that intramitochondrial oxidative stress *regulates* [MMP-9] via ERK-1/2 signal cascade . Positive_regulation MMP9 CAPN8 21911754 2497146 In cultured cardiac fibroblasts , high glucose induced proliferation and [MMP] activities were *prevented* by inhibition . Positive_regulation MMP9 CAPN8 21964156 2525924 Inhibition of , a calcium activated neutral cysteine protease , by overexpression of its endogenous inhibitor , calpastatin , *attenuates* AngII induced leukocyte infiltration , perivascular inflammation , and [MMP] activation in mice . Positive_regulation MMP9 CAPN8 22316244 2553430 On the other hand , inhibition of activity upon treatment with leupeptin or MDL 28170 significantly *reduced* the [MMP] activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity . Positive_regulation MMP9 CCND1 22401982 2587754 Treatment with this multifunctional drug also *inhibited* secretion of [matrix metalloproteinase-9] in primary tumor cells from PyMT mice and decreased proliferation of these cells by inhibiting and decreasing phosphorylation of epidermal growth factor receptor and STAT3 . Positive_regulation MMP9 CD14 19920349 2171825 In vitro , coculture of monocytes and aortic adventitial fibroblasts produced MCP-1- and IL-6 enriched conditioned medium that promoted differentiation of monocytes into macrophages , induced and CD11b upregulation , and *induced* MCP-1 and [MMP-9] expression . Positive_regulation MMP9 CHI3L1 21866546 2599264 We found that in vitro inhibition of by siRNA *suppressed* the production of CCL2 , CXCL2 and [MMP-9] by macrophages . Positive_regulation MMP9 CLU 24085798 2902608 Our results indicate that platelet secreted TSP1 and *promote* the signal regulation of [MMP-9] in platelet induced colonic cancer invasion via a P38MAPK regulated pathway . Positive_regulation MMP9 CTGF 18632843 1979326 In conclusion , upregulation of inhibits BMP-7 signal transduction in the diabetic kidney and *contributes* to altered gene transcription , reduced [MMP] activity , glomerular basement membrane thickening , and albuminuria , all of which are hallmarks of diabetic nephropathy . Positive_regulation MMP9 EPHB2 11069776 747867 Sustained phosphorylation is *necessary* but not sufficient for [MMP-9] regulation in endothelial cells : involvement of Ras dependent and -independent pathways . Positive_regulation MMP9 EPHB2 11315098 765096 In the current study , we examined the *role* of JNK- and dependent signaling modules in the regulation of [MMP-9] production and the invasive behavior of the human glioblastoma cell line SNB19 , in which JNK/ERK1 is constitutively activated . Positive_regulation MMP9 EPHB2 11509539 848313 Stimulation of VSM cells with IL-1 beta significantly ( P < 0.05 ) increased superoxide production , activation , and [MMP-9] *induction* . Positive_regulation MMP9 EPHB2 11509539 848317 In addition , pretreatment of VSM cells with a specific ERK pathway inhibitor , PD-98059 , or DETA NONOate inhibited IL-1 beta stimulated activation and [MMP-9] *induction* . Positive_regulation MMP9 EPHB2 11509539 848322 Direct exposure of VSM cells to increased superoxide levels by treatment with xanthine/xanthine oxidase increased ERK activation and MMP-9 induction , whereas pretreatment of cells with PD-98059 significantly ( P < 0.05 ) inhibited xanthine/xanthine oxidase stimulated activation and [MMP-9] *induction* . Positive_regulation MMP9 EPHB2 11709424 879800 Role of reactive oxygen species in IL-1 beta stimulated sustained activation and [MMP-9] *induction* . Positive_regulation MMP9 EPHB2 11709424 879803 To determine the *role* of in IL-1 beta stimulated [MMP-9] induction , we treated cells with the specific ERK pathway inhibitor PD-98059 at different time intervals after IL-1 beta stimulation . Positive_regulation MMP9 EPHB2 11709424 879807 The results demonstrate that IL-1 beta dependent [MMP-9] induction is *mediated* by superoxide stimulated activation . Positive_regulation MMP9 EPHB2 12458339 1021608 However , only inhibition of Src and could *block* KGF stimulated secretion of uPA and [MMP-9] . Positive_regulation MMP9 EPHB2 14709335 1196668 pathway inhibitors , PD98059 and U0126 , *down-regulated* IL-17 induced [MMP] and ADAM-TS4 gene expression . Positive_regulation MMP9 EPHB2 14755547 1205645 In addition , the transcription factors NF-kappaB and AP-1 that are involved in the *mediated* control of [MMP-9] regulation on HASMC in response to TNF-alpha have now been identified . Positive_regulation MMP9 EPHB2 15197768 1260407 Selective inhibition of ( by PD98059 or U0126 ) and PI3K ( by LY294002 or wortmannin ) *led* to marked reduction of both basal and BTC induced [MMP-9] activity and invasive ability of HNSCC cells . Positive_regulation MMP9 EPHB2 15728252 1382892 Inhibition of MEK/ERK signaling in wild-type MK cells with a pharmacological inhibitor , U0126 , showed that activation was *necessary* for high levels of endogenous MMP-9 gene expression and activity of a transfected [MMP-9] promoter . Positive_regulation MMP9 EPHB2 15728252 1382893 Furthermore , activation of signaling in these cells with an oncogenic mutant of Ras , RasV12 , *increased* both endogenous MMP-9 gene expression and [MMP-9] promoter activity . Positive_regulation MMP9 EPHB2 15728252 1382902 However , alpha3beta1 was not required for RasV12 mediated activation of ERK or for *dependent* [MMP-9] promoter activity . Positive_regulation MMP9 EPHB2 16350852 1492422 But neither p38 MAP kinase nor JNK inhibitor had an effect on TNF-alpha induced MMP-9 expression , suggesting that activation is *required* for the [MMP-9] induction by TNF-alpha . Positive_regulation MMP9 EPHB2 16867053 1592822 Frass increased ERK phosphorylation , and chemical inhibition of *attenuated* cockroaches ' effects on [MMP-9] . Positive_regulation MMP9 EPHB2 16882662 1625579 The inhibitor of , PD98095 , and of PI3K , wortmannin , but not that of protein kinase A , H89 , of Rho kinase , Y-27632 , of mTOR , rapamycin , or of JNK , SP600125 , *prevented* FN-induced [MMP-9] gelatinolytic activity and gene expression . Positive_regulation MMP9 EPHB2 17072348 1716614 Induction of [MMP-9] by TGF-beta-ALK5 signaling *requires* but not JNK , p38 MAPK or Smad4 . Positive_regulation MMP9 EPHB2 17079649 1684069 [MMP-9] secretion from CoMTB stimulated astrocytes is *dependent* on the activity of p38 , , and Jnk MAPKs . Positive_regulation MMP9 EPHB2 18312464 1891765 Inhibition of phosphorylation induced by B-1 cells with inhibitors of MEK1/2 strongly *suppressed* the induction of [MMP-9] and CXCR-4 mRNA expression and impaired the increased metastatic behavior of B16 . Positive_regulation MMP9 EPHB2 18628248 1954503 A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal regulated kinase ( ERK ) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated , and TPA induced [MMP-9] activation and migration were *inhibited* by the pan PKC inhibitor , GF109203X , the specific PKCdelta inhibitor , rottlerin , an inhibitor ( PD98059 ) and an AP-1 inhibitor ( curcumin ) . Positive_regulation MMP9 EPHB2 20107538 2178635 Stimulation of CD147 with its specific monoclonal antibody induced the expression of [matrix metalloproteinase (MMP)-9] in THP-1 cells and it was *suppressed* by inhibitors of both and NF-kappaB . Positive_regulation MMP9 EPHB2 20458747 2307543 12-O-tetradecanoylphorbol-13-acetate induced invasion/migration of glioblastoma cells through activating *dependent* [MMP-9] expression . Positive_regulation MMP9 EPHB2 20458747 2307553 Activation of extracellular signal regulated kinase ( ERK ) and c-Jun-N-terminal kinase (JNK) by TPA was identified , and TPA induced migration and [MMP-9] activity was significantly *blocked* by inhibitor PD98059 and U0126 , but not JNK inhibitor SP600125 . Positive_regulation MMP9 EPHB2 20491781 2288869 Taken together , these results reveal that 67LR promotes the invasive and metastatic ability of the gastric cancer cells through *increasing* uPA and [MMP 9] expression , with involvement of the and JNK signal pathway in hypoxia induced 67 LR expressions and subsequent uPA and MMP9 expression . Positive_regulation MMP9 EPHB2 20638679 2504604 Inhibition of ( UO126 ) or p38 ( SB203580 ) , but not PI3K ( LY294002 or wortmannin ) , *blocked* AGE induced [MMP-9] expression . Positive_regulation MMP9 EPHB2 20718733 2345723 By using specific inhibitors , it was demonstrated that and NF-?B signalling , but not JNK and p38 signalling , were *involved* in PMA stimulated [MMP-9] activation . Positive_regulation MMP9 EPHB2 20843518 2353075 Taken together , this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and *dependent* [MMP] expression by U937 cells , suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling . Positive_regulation MMP9 EPHB2 21120482 2469501 The PI3 K or inhibitors also *attenuated* expression of VEGF and [MMP-9] . Positive_regulation MMP9 EPHB2 21170925 2521313 In CT-26 cells , the extracellular signal regulated kinase ( ) inhibitor *inhibited* cell proliferation , invasion and [MMP-9] expression , and the c-Jun N-terminal kinase (JNK) inhibitor suppressed the expression of both MMPs , as well as cell proliferation and cell invasion . Positive_regulation MMP9 EPHB2 22519702 2618494 Furthermore , constitutive activation , which was inhibited by Rac1 , significantly *increased* [MMP9] transcription in cells expressing SP-1WT , but not SP-1S586A . Positive_regulation MMP9 EPHB2 22835547 2670973 Studies using chemical inhibitors and siRNAs to signaling molecules showed that PI3K , Akt , and PKC-? and the transcription factors Elk-1 , c-fos and , to a lesser extent , NF-?B are *involved* in relaxin 's induction of [MMP-9] . Positive_regulation MMP9 EPHB2 23271730 2741871 Blockade of p21 ( WAF1 ) function by siRNA reversed migration , invasion , *activation* of signaling , [MMP-9] expression , and activation of NF-?B in IL-20 treated cells . Positive_regulation MMP9 EPHB2 23306155 2746519 Derlin-1 is overexpressed in non-small cell lung cancer and promotes cancer cell invasion via *mediated* up-regulation of MMP-2 and [MMP-9] . Positive_regulation MMP9 EPHB2 23306155 2746533 In summary , our results showed that Derlin-1 is overexpressed in NSCLC and promotes invasion by *mediated* up-regulation of MMP-2 and [MMP-9] . Positive_regulation MMP9 EPHB2 24012928 2862362 Levosimendan ( 10 and 100 µM ) inhibited IL-1ß induced migration , and CTTHWGFTLC peptide ( 10 µM ) , an [MMP] *inhibitor* , or PD98059 ( 50 µM ) , an inhibitor , also suppressed it . Positive_regulation MMP9 EPHB2 24188385 2890269 Co-culture with CM resulted in an increased resistance to Adriamycin and enhanced expressions of a-FP , [MMP9] , ABCG2 , CD133 , and SOX2 , as well as the *activation* of , AKT , WNT , and TGF-ß1 pathways . Positive_regulation MMP9 F2R 18502312 1917758 These results suggest that the activation of *mediates* thrombin induced [MMP-9] expression through the regulation of Erk1/2 . Positive_regulation MMP9 FAS 12673046 1076511 The recruitment was blocked by a specific MMP-9 inhibitor , R94138 , which did not affect the *mediated* liver injury or induced expression of [MMP-9] . Positive_regulation MMP9 FAS 16316466 1493950 When compared to WT , mutant astrocytes displayed an overall increased constitutive gelatinase expression and were less responsive to *mediated* upregulation of [MMP-9] , of monocyte chemoattractant protein-1 ( MCP-1 ) and of intercellular cell adhesion molecule-1 ( ICAM-1 ) , all markers of astrocyte inflammatory response . Positive_regulation MMP9 IGFBP1 15590975 1346164 Cell numbers were increased only by 100 nM IGFBP-1 isoforms ( P < 0.05 ) , whereas [MMP] levels released from term cells were optimally *increased* by 1-10 nM . Positive_regulation MMP9 IL1B 10547161 564708 *upregulates* [MMP-9] expression in stromal cells of human giant cell tumor of bone . Positive_regulation MMP9 IL1B 10547161 564710 Moreover , nuclear run-on analysis has revealed that significantly *increased* [MMP-9] gene transcription in GCT stromal cells . Positive_regulation MMP9 IL1B 10620188 657449 Using the NO donors S-Nitroso-N-acetyl-D , L-penicillamine ( SNAP ) and DETA-NONOate , we found strong inhibitory effects of NO mainly on the *induced* [MMP-9] mRNA levels . Positive_regulation MMP9 IL1B 10727770 678134 and TPA alone *induced* [MMP] activity in HIG-82 cells . Positive_regulation MMP9 IL1B 10734001 678605 In vitro activation of CNS endothelium with the pro-inflammatory cytokines , tumour necrosis factor-alpha and , *resulted* in selective upregulation of [MMP-9] activity , whereas no significant changes were seen in MMP-2 or TIMP-2 levels at 24 h . Positive_regulation MMP9 IL1B 10864917 705859 and TNF-alpha each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP9 IL1B 10895370 711617 In support of this result , stimulation *induced* the expression of membrane type matrix-metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2 specific activator , in rheumatoid osteoblasts . Positive_regulation MMP9 IL1B 10967046 728289 In conjunctivochalasis fibroblasts and normal conjunctival fibroblasts , TNF-alpha , but not , *induced* a gelatinolytic activity of [MMP-9] , which was further confirmed by Western blot analysis and ELISA . Positive_regulation MMP9 IL1B 11029344 739830 Airway macrophages from smokers released greater amounts of [MMP-9] and TIMP-1 at baseline and in *response* to and LPS than did those of nonsmokers . Positive_regulation MMP9 IL1B 11067938 747569 Amplification of *induced* [matrix metalloproteinase-9] expression by superoxide in rat glomerular mesangial cells is mediated by increased activities of NF-kappa B and activating protein-1 and involves activation of the mitogen activated protein kinase pathways . Positive_regulation MMP9 IL1B 11067938 747570 Recently , we have shown that NO reduces *induced* matrix metalloproteinase ( [MMP-9] ) expression in glomerular mesangial cells ( MC ) . Positive_regulation MMP9 IL1B 11244573 792403 Stimulation of CaCO-2 cells with or tumor necrosis factor-alpha (TNF-alpha) *led* to a dose dependent increase in expression and secretion of [MMP-9] . Positive_regulation MMP9 IL1B 11327259 807611 A decrease in IL-1alpha , , and IL-6 would *reduce* stimulation of [MMP] production , while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves . Positive_regulation MMP9 IL1B 11467889 840808 In all cases , PC specifically reversed the differential regulation of MMPs and TIMPs by BCP crystals but had no effect on *induction* of [MMP] expression . Positive_regulation MMP9 IL1B 11506743 848004 Tumor necrosis factor-alpha (TNF-alpha) but not lipopolysaccharide (LPS) stimulation *caused* a significant increase in [gelatinase B] production in zymography analysis . Positive_regulation MMP9 IL1B 11509539 848310 Recently , we demonstrated that nitric oxide ( NO ) inhibits *stimulated* [MMP-9] induction in rat aortic VSM cells . Positive_regulation MMP9 IL1B 11509539 848314 Stimulation of VSM cells with significantly ( P < 0.05 ) *increased* superoxide production , ERK activation , and [MMP-9] induction . Positive_regulation MMP9 IL1B 11509539 848318 In addition , pretreatment of VSM cells with a specific ERK pathway inhibitor , PD-98059 , or DETA NONOate inhibited stimulated ERK activation and [MMP-9] *induction* . Positive_regulation MMP9 IL1B 11509539 848323 We conclude that NO inhibits *stimulated* [MMP-9] induction by inhibiting superoxide generation and subsequent ERK activation . Positive_regulation MMP9 IL1B 11709424 879804 To determine the role of ERK in *stimulated* [MMP-9] induction , we treated cells with the specific ERK pathway inhibitor PD-98059 at different time intervals after IL-1 beta stimulation . Positive_regulation MMP9 IL1B 11709424 879806 In addition , both NAC treatment and MnSOD overexpression significantly inhibited *stimulated* [MMP-9] induction ( P < 0.05 ) . Positive_regulation MMP9 IL1B 11709424 879808 The results demonstrate that *dependent* [MMP-9] induction is mediated by superoxide stimulated ERK activation . Positive_regulation MMP9 IL1B 11747375 889299 Both and TNF-alpha *augmented* [MMP-9] expression in HT1080 cells . Positive_regulation MMP9 IL1B 11825017 892932 Semi-quantitative RT-PCR and Northern hybridization disclosed that the [MMP-9] transcript was also markedly *up-regulated* in a dose dependent manner by and TNF-alpha . Positive_regulation MMP9 IL1B 11970913 933285 LPS and *caused* a dose dependent increase in [MMP-9] release and activity , together with increased levels of TIMP-1 . Positive_regulation MMP9 IL1B 11997239 939307 produced a dose dependent *increase* in [MMP] activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min . Positive_regulation MMP9 IL1B 12050953 950457 stimulation produced an *increase* in the amount of [MMP-9] expressed , as determined by the zymography method with a maximum effect 36 hours after stimulation . Positive_regulation MMP9 IL1B 12387824 999853 *induces* [MMP-9] via reactive oxygen species and NF-kappaB in murine macrophage RAW 264.7 cells . Positive_regulation MMP9 IL1B 12387824 999854 Transient transfection study using a MMP-9 promoter-reporter construct showed that *enhanced* the [MMP-9] promoter activity . Positive_regulation MMP9 IL1B 12387824 999855 Electrophoretic mobility shift assay and site directed mutagenesis study on the consensus binding site for NF-kappaB revealed that the activation of NF-kappaB is required for the *induced* activation of [MMP-9] promoter . Positive_regulation MMP9 IL1B 12387824 999858 These results suggest that *upregulates* the [MMP-9] expression via production of reactive oxygen species and activation of NF-kappaB in RAW 264.7 cells . Positive_regulation MMP9 IL1B 14523003 1174317 ATP potentiates *induced* [MMP-9] expression in mesangial cells via recruitment of the ELAV protein HuR . Positive_regulation MMP9 IL1B 14751736 1205533 Non-phagocytable particles *induced* more [MMP-9] , although phagocytable particles induced more release . Positive_regulation MMP9 IL1B 14872494 1208461 Preincubation with anti-CD44 antibody , which suppressed IL-1beta stimulated MMPs , reversed the inhibitory effect of HA on [MMP] production that was *induced* by in normal and OA cartilage . Positive_regulation MMP9 IL1B 15037119 1224005 In this study , we have investigated the *roles* of and mitogen activated protein kinases in [MMP-9] induction in the retina . Positive_regulation MMP9 IL1B 15269222 1290330 Using adult rat cardiac fibroblasts , we show that inhibition of ERK1/2 and JNKs inhibits *stimulated* increases in [MMP-9] , not MMP-2 , expression and activity . Positive_regulation MMP9 IL1B 15269222 1290334 Inhibition of PKC-theta and PKC-zeta using pseudosubstrates inhibited *stimulated* activation of ERK1/2 and JNKs and the expression and activity of [MMP-2 and -9] . Positive_regulation MMP9 IL1B 15269222 1290338 SN50 , NF-kappaB inhibitor peptide , inhibited *stimulated* increases in [MMP-2 and -9] expression and activity . Positive_regulation MMP9 IL1B 15341531 1291737 Involvement of p42/p44 MAPK , p38 MAPK , JNK and nuclear factor-kappa B in *induced* [matrix metalloproteinase-9] expression in rat brain astrocytes . Positive_regulation MMP9 IL1B 15341531 1291752 [Matrix metalloproteinase (MMP)-9] expression *induced* by was investigated in rat brain astrocyte-1 ( RBA-1 ) . Positive_regulation MMP9 IL1B 15341531 1291753 Here we report that the mitogen activated protein kinases ( MAPKs ) and nuclear factor-kappa B (NF-kappaB) pathways participate in the *induction* of [MMP-9] expression by . Positive_regulation MMP9 IL1B 15341531 1291773 Taken together , these results suggest that in RBA-1 cells , activation of p42/p44 MAPK , p38 , JNK and NF-kappaB pathways is essential for *induced* [MMP-9] gene expression via transcription and translation processes . Positive_regulation MMP9 IL1B 15341531 1291786 An increased understanding of the signal transduction pathways involved in *induced* [MMP-9] expression on RBA-1 may be of potential therapeutic value in the treatment of inflammatory disease . Positive_regulation MMP9 IL1B 15458430 1301524 TNF-alpha and *mediated* regulation of [MMP-9] and TIMP-1 in renal proximal tubular cells . Positive_regulation MMP9 IL1B 15458430 1301530 TNF-alpha but not *resulted* in a dose dependent increase in the latent form of [MMP-9] . Positive_regulation MMP9 IL1B 15666191 1365649 SHP-2 promoting migration and metastasis of MCF-7 with loss of E-cadherin , dephosphorylation of FAK and secretion of [MMP-9] *induced* by in vivo and in vitro . Positive_regulation MMP9 IL1B 15666191 1365650 These results demonstrate that SHP-2 promotes invasion and metastasis of MCF-7 with the loss of E-cadherin , the dephosphorylation of FAK and the secretion of [MMP-9] *induced* by . Positive_regulation MMP9 IL1B 15963473 1428107 We demonstrate that the GR agonist RU 24858 , equipotent to dexamethasone ( DEX ) , exhibited strong suppressive effects on the *induced* [MMP-9] and tPA mRNA levels concomitant with an inhibition of corresponding enzyme activities . Positive_regulation MMP9 IL1B 16148153 1455152 Chondrocytes and synoviocytes , the resident cells of joint capsule , markedly increase transcription of [MMP-9] in *response* to and TNF-alpha mediated stimulation . Positive_regulation MMP9 IL1B 16376111 1553941 The NF-kappaBp65-specific siRNA inhibited the expression of NF-kappaBp65 and activation of NF-kappaB , reducing significantly the expression of COX-2 , NOS-2 and [MMP-9] *induced* by and tumor necrosis factor-alpha (TNF-alpha) in cultured chondrocytes . Positive_regulation MMP9 IL1B 16378139 1505356 DETA decreased *induced* [MMP-9] expression and activity in both RA-SMCs and RAEs in a dose dependent fashion . Positive_regulation MMP9 IL1B 16449361 1573886 HA at > or =2 mg/ml significantly inhibited [MMP] production *induced* by in a dose dependent manner . Positive_regulation MMP9 IL1B 16449361 1573908 Inhibition studies revealed the requirement of NF-kappaB , p38 and c-jun NH2-terminal kinase ( JNK ) for *induced* [MMP] production . Positive_regulation MMP9 IL1B 16565381 1538932 JNK activity is necessary for the *induction* of MMP-9 and] [TNFalpha by IL-1alpha , , or Jun in TM cells . Positive_regulation MMP9 IL1B 16689658 1560317 In this study , and tumor necrosis factor-alpha (TNF-alpha) , commonly elevated in chronic C hepatitis , *stimulate* the production of [matrix metalloprotease-9 (MMP-9)] by human hepatocytes at a transcriptional and translational level , but the addition of recombinant interferon-alpha2b ( rIFN-alpha2b ) hampers this effect . Positive_regulation MMP9 IL1B 16718267 1565261 In addition , both tumor necrosis factor-alpha and are strong *inducers* of active [matrix metalloproteinase-9] in vertical growth phase melanoma cell lines , indicating a possible role of these cytokines in the switch from radial growth phase to vertical growth phase . Positive_regulation MMP9 IL1B 16787167 1577473 TNFalpha and *stimulate* macrophages to produce matrix metalloproteinase-9 [ [MMP-9] ] , and bronchial epithelial cells to produce extracellular matrix glycoproteins . Positive_regulation MMP9 IL1B 16939904 1609342 MMP-9 was expressed at the level of 1,491.38-/+68.95 in the control group , and at 1 ,592.40-/+47.57 , 1,702.63-/+75.31 , 1,994.49-/+52.98 , and 2,347.58-/+45.87 in response to cell treatment with IL-1beta at 50 , 100 , 500 , and 1,000 U/ml , respectively , suggesting that significantly *increased* [MMP-9] expression in a dose dependent manner ( P < 0.05 ) . Positive_regulation MMP9 IL1B 17011110 1746982 After treatment with IL-1beta , IkappaB was degraded by almost 90 % within 5 min and became undetectable by 15 min . stimulation *increased* the levels of COX-2 protein and the gelatinolytic activities of [MMP-9] , both of which were inhibited by NF-kappaB inhibitors . Positive_regulation MMP9 IL1B 17079649 1684067 and TNF-alpha are *necessary* but not sufficient for such induction of astrocyte [MMP-9] secretion . Positive_regulation MMP9 IL1B 17109889 1676659 and interleukin-6 *stimulate* [matrix metalloproteinase-9] secretion in cultured myenteric glia . Positive_regulation MMP9 IL1B 17202418 1688825 The effects of the immunosuppressants cyclosporin A ( CsA ) and tacrolimus ( FK506 ) on the *induced* [matrix metalloproteinase-9 (MMP-9)] were investigated . Positive_regulation MMP9 IL1B 17311279 1719256 *induces* [MMP-9] expression via p42/p44 MAPK , p38 MAPK , JNK , and nuclear factor-kappaB signaling pathways in human tracheal smooth muscle cells . Positive_regulation MMP9 IL1B 17311279 1719257 However , the mechanisms underlying [MMP-9] expression *induced* by in human tracheal smooth muscle cells ( HTSMCs ) remain unclear . Positive_regulation MMP9 IL1B 17311279 1719259 Here , we investigated the roles of p42/p44 MAPK , p38 MAPK , JNK , and NF-kappaB pathways for *induced* [MMP-9] production in HTSMCs . Positive_regulation MMP9 IL1B 17311279 1719303 Finally , the reporter gene assay revealed that MAPKs and NF-kappaB are required for *induced* [MMP-9] luciferase activity in HTSMCs . Positive_regulation MMP9 IL1B 17311279 1719306 [MMP-9] promoter activity was *enhanced* by in HTSMCs transfected with MMP-9-Luc , which was inhibited by helenalin , U0126 , SB202190 , and SP600125 . Positive_regulation MMP9 IL1B 17328062 1711909 SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on *stimulated* [MMP] production and collagen degradation . Positive_regulation MMP9 IL1B 17890880 1811204 TNF-alpha and *mediated* regulation of [MMP-9] and TIMP-1 in human glomerular mesangial cells . Positive_regulation MMP9 IL1B 17890880 1811214 TNF-alpha but not *resulted* in a dose dependent increase in the latent form of [MMP-9] and a decrease in TIMP-1 production . Positive_regulation MMP9 IL1B 17925024 1835457 These findings demonstrate , for the first time , that glucosamine inhibits *stimulated* [MMP] production in human chondrocytes by affecting MAPK phosphorylation . Positive_regulation MMP9 IL1B 17939964 1844449 *induced* the release of astrocytic [MMP-9] in cocultures , whilst an antagonist of MMP-9 inhibited IL-1beta induced neuronal death . Positive_regulation MMP9 IL1B 17989112 1850955 In summary , these data indicate that inhibited ANG II-mediated type IV collagen production , via CTGF downregulation , and *increased* type IV collagen degradation , through [MMP-9] upregulation . Positive_regulation MMP9 IL1B 18276934 1911665 [Matrix metalloproteinase 9 (MMP9)] expression in preeclamptic decidua and MMP9 *induction* by tumor necrosis factor alpha and in human first trimester decidual cells . Positive_regulation MMP9 IL1B 18276934 1911671 Similarly , quantitative RT-PCR found that TNF and *enhanced* [MMP9] , but not MMP2 , mRNA levels . Positive_regulation MMP9 IL1B 18403593 1899541 DHA significantly decreased VSMC migration/proliferation *induced* by as well as [fibrinolytic/MMP] activity . Positive_regulation MMP9 IL1B 18434122 1926383 Neither nor TNF-alpha treated SV40-T2 cells *increased* the secretion of [MMP-9] and MMP-2 . Positive_regulation MMP9 IL1B 18535174 1928808 *stimulated* [MMP] mRNA synthesis in wild-type , but not in IL-1RI-null cardiac fibroblasts . Positive_regulation MMP9 IL1B 18824875 1981579 Nitric oxide involvement in TNF-alpha and *mediated* changes in human mesangial cell [MMP-9] and TIMP-1 . Positive_regulation MMP9 IL1B 18980250 1995273 However , MMP-12 enhanced expression and activation of [MMP-9] in the *presence* of . Positive_regulation MMP9 IL1B 19056796 2017725 Cordycepin is a potent inhibitor of *induced* chemokine production and [MMP] expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs . Positive_regulation MMP9 IL1B 19109223 2047677 Lipoic acid pretreatment also inhibited TNF- and *induced* increases in [MMP9] protein activity and release in amnion epithelial cells , as well as PGE ( 2 ) increases in both amnion epithelial and mesenchymal cells . Positive_regulation MMP9 IL1B 19427585 2076794 It was found that *induced* the activity of MMP-2 and [MMP-9] during the 48 h time course of the experiment , especially after 24h incubation , while DETA/NO , donor of NO , stimulated the process at 12h incubation . Positive_regulation MMP9 IL1B 19542681 2099208 *induced* [MMP] production has been shown to be mediated by extracellular signal regulated protein kinase ( ERK ) , p38 kinase , and c-Jun N-terminal kinase (JNK) of the mitogen activated protein kinase (MAPK) family signal transduction molecules . Positive_regulation MMP9 IL1B 19616091 2124138 However , the mechanisms underlying *induced* [MMP-9] expression and cell migration in human A549 cells remain unclear . Positive_regulation MMP9 IL1B 19616091 2124139 Here , we report that the *induced* [MMP-9] gene expression was mediated through the activation of p42/p44 MAPK , p38 MAPK , and JNK1/2 in A549 cells , determined by zymographic , RT-PCR , and Western blotting . Positive_regulation MMP9 IL1B 19616091 2124142 Moreover , the *induced* [MMP-9] gene expression was also mediated through the translocation of NF-kappaB ( p65 ) into the nucleus and the degradation of I kappaB alpha . Positive_regulation MMP9 IL1B 19616091 2124144 *stimulated* the transcriptional activity of wild-type [MMP-9] promoter in A549 cells , which was inhibited by U0126 , SB203580 , SP600125 , and helenalin . Positive_regulation MMP9 IL1B 19616091 2124145 Finally , the *induced* [MMP-9] expression led to cell migration which was attenuated by pretreatment with U0126 , SB203580 , SP600125 , helenalin , or MMP-2/9 inhibitor . Positive_regulation MMP9 IL1B 19616091 2124147 These results suggested that in A549 cells , the activation of p42/p44 MAPK , p38 MAPK , JNK1/2 , NF-kappaB , and AP-1 are essential for the *induced* [MMP-9] gene expression and cell migration . Positive_regulation MMP9 IL1B 19910936 2272036 Post-fat load , circulating levels of WBC , MMP-1 , and [MMP-9] *increased* by 16 , 32 , and 43 % ( all P < 0.0001 ) , with no significant changes in . Positive_regulation MMP9 IL1B 20145375 2280991 Angiotensin II enhances *induced* [MMP-9] secretion in adult rat cardiac fibroblasts . Positive_regulation MMP9 IL1B 20145375 2280993 In the present study , we investigated the effect of angiotensin II on basal and *induced* [MMP-9] secretion in adult rat cardiac fibroblasts . Positive_regulation MMP9 IL1B 20145375 2280994 Telmisartan ( 10 nM ) , an angiotensin II type 1 receptor (AT1R) antagonist , significantly suppressed the enhancement of *induced* [MMP-9] secretion by angiotensin II , whereas PD123319 ( 10 nM ) , an angiotensin II type 2 receptor antagonist , was ineffective . Positive_regulation MMP9 IL1B 20145375 2281002 PD98059 ( 50 microM ) , a selective inhibitor of ERK pathway , inhibited the angiotensin II enhancement of *induced* [MMP-9] secretion . Positive_regulation MMP9 IL1B 20145375 2281003 These results suggest that angiotensin II enhances *induced* [MMP-9] secretion through the augmentation of ERK phosphorylation via AT1R in adult rat cardiac fibroblasts . Positive_regulation MMP9 IL1B 20403707 2282296 *induced* [MMP] production was significantly augmented in the presence of sIL-6R . Positive_regulation MMP9 IL1B 20649564 2293105 *induces* expression of [matrix metalloproteinase-9] and cell migration via a c-Src dependent , growth factor receptor transactivation in A549 cells . Positive_regulation MMP9 IL1B 20649564 2293106 *induced* matrix metalloproteinase ( [MMP-9] ) expression is regulated by mitogen activated protein kinases ( MAPKs ) and NF-kappaB . Positive_regulation MMP9 IL1B 20649564 2293107 Here , we investigated whether these transactivation mechanisms participated in *induced* [MMP-9] expression in A549 cells . Positive_regulation MMP9 IL1B 20649564 2293108 *induced* [MMP-9] expression and cell migration was mediated through c-Src dependent transactivation of EGFR/PDGFR/PI3K/Akt linking to the NF-kappaB pathway in A549 cells . Positive_regulation MMP9 IL1B 20678474 2311835 MMP-2 gene expression as well as enzymatic activities of MMP-2 and [MMP-9] were *increased* by ( P < 0.05 vs. control ; 100ng/ml ; 3h for gene expression , 48 and 72h for enzymatic activities of MMP-2 and MMP-9 , respectively ) . Positive_regulation MMP9 IL1B 21344389 2480452 These findings establish CEBPB as a critical intermediate for dependent [MMP] gene *activation* and assign specific roles for the ERK and RSK kinases in this pathway . Positive_regulation MMP9 IL1B 22792188 2628393 Pharmacologic [MMP/ADAM] inhibitors and siRNA knockdown prevent *induction* of Egr-1 . Positive_regulation MMP9 IL1B 8006017 258035 *stimulated* trophoblast [MMP-9] secretion ( by a mechanism that required nascent mRNA and protein synthesis ) as well as metalloproteinase activity and invasion of Matrigel . Positive_regulation MMP9 IL1B 8006017 258036 Increasing ( by lipopolysaccharide treatment ) or decreasing ( by glucocorticoid treatment ) production *had* parallel effects on [MMP-9] secretion , metalloproteinase activity , and invasion . Positive_regulation MMP9 IL1B 8139259 252061 However , keratinocyte [MMP-9] production was *enhanced* by , transforming growth factor beta-1 , and tumor necrosis factor-alpha . Positive_regulation MMP9 IL1B 8587235 341508 In vitro , the transduced mesangial cells showed a reduced mitogenic response to fetal calf serum and were insensitive to *induction* of [matrix metalloproteinase-9 (MMP-9)] by the proinflammatory cytokine . Positive_regulation MMP9 IL1B 8587235 341509 After 24 hours , isolated glomeruli containing transfectants exhibited TGF-beta bioactivity , a reduced mitogenic response , and repressed expression of [MMP-9] in *response* to . Positive_regulation MMP9 IL1B 8764135 378576 Secretion of [gelatinase B] by LuM1 cells was *augmented* by tumor necrosis factor alpha , transforming growth factor beta1 ( TGF-beta1 ) , , or epidermal growth factor , and specific neutralizing antibodies abolished the induced increases . Positive_regulation MMP9 IL1B 8769830 379121 Glomerular mesangial cells express [matrix metalloproteinase-9 (MMP-9)] in *response* to the proinflammatory cytokine . Positive_regulation MMP9 IL1B 8769830 379123 In rat mesangial cells treated with an inhibitor of NF-kappa B , pyrrolidine dithiocarbamate , *induction* of [MMP-9] by was suppressed at both mRNA and protein levels . Positive_regulation MMP9 IL1B 8769830 379125 These results suggest that *induced* [MMP-9] via the stimulation of NF-kappa B pathway . Positive_regulation MMP9 IL1B 8769830 379127 This inhibitor dose dependently suppressed the expression of [MMP-9] , as well as the *activation* of the kappa B site by , indicating the involvement of tyrosine kinase in the stimulation of NF-kappa B . Positive_regulation MMP9 IL1B 8769830 379129 Similarly , depletion of intracellular PKC did not obviously affect the *induction* of [MMP-9] by . Positive_regulation MMP9 IL1B 8769830 379130 These findings demonstrate that dual operation of tyrosine kinase mediated NF-kappa B stimulation and c-Jun/AP-1 activation is essential to the *induction* of [MMP-9] by in cultured mesangial cells . Positive_regulation MMP9 IL1B 8831705 385817 Compared to mock transfectants , the vector cells showed blunted expression of [gelatinase B] , stromelysin and monocyte chemoattractant protein-1 in *response* to . Positive_regulation MMP9 IL1B 8831705 385820 Compared to either unmodified or mock cell containing glomeruli , the glomeruli transferred with vector cells showed repressed expression of [gelatinase B] in *response* to . Positive_regulation MMP9 IL1B 8892653 392143 TNF-alpha and selectively *induce* expression of [92-kDa gelatinase] by human macrophages . Positive_regulation MMP9 IL1B 8892653 392146 IFN-gamma suppressed the production of the [92-kDa gelatinase] *induced* by TNF-alpha- and . Positive_regulation MMP9 IL1B 8892653 392148 TNF-alpha and *regulated* the expression of [92-kDa gelatinase] by monocyte derived macrophages at the pretranslational level . Positive_regulation MMP9 IL1B 9357863 462078 Divergent regulation of [92-kDa gelatinase] and TIMP-1 by HBECs in *response* to and TNF-alpha . Positive_regulation MMP9 IL1B 9558121 500112 Recombinant TNF-alpha and added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP9 IL1B 9631748 512579 Moreover , TNF-alpha as well as *induced* the expression of [MMP9] . Positive_regulation MMP9 IL1B 9743373 532505 TNF-alpha , granulocyte-macrophage-CSF (GM-CSF) , or when added individually *enhanced* the endogenous levels of [92-kDa gelatinase] ( MMP-9 ) and TIMP-1 but failed to induce interstitial collagenase ( MMP-1 ) . Positive_regulation MMP9 IL1B 9821179 548130 The inflammatory cytokine did not *induce* [MMP] or TIMP expression . Positive_regulation MMP9 IL1B 9890433 585427 A beta , but not or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells , as well as *increased* the expression of the well-known activator of MMP-2 , membrane-type ( MT ) [-MMP] . Positive_regulation MMP9 IL1B 9933437 589416 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by and TNF-alpha or down-regulated by IFN-gamma . Positive_regulation MMP9 ITGB2 19728062 2175870 Additionally , blockade significantly *inhibited* the Ang-2/PDGF-BB based increase in [matrix metalloproteinase-9 (MMP-9)] and membrane type-1-MMP (MT1-MMP) . Positive_regulation MMP9 ITGB2 20800911 2493862 These results suggest that stent induced activation of on the surface of neutrophils might *trigger* their [MMP-9] release , possibly leading to the mobilization of bone marrow derived stem cells . Positive_regulation MMP9 ITGB2 9754865 535244 Ligation of selectin L and integrin ( Mac-1 ) *induces* release of [gelatinase B] ( MMP-9 ) from human neutrophils . Positive_regulation MMP9 LGALS7B 15958565 1422775 This hypothesis is based on the following evidence : ( a ) galectin-7 transfectants have higher levels of MMP-9 expression , ( b ) addition of beta-lactose completely inhibits expression of [MMP-9] by galectin-7 transfectants , and ( c ) recombinant forms of *induces* the expression of MMP-9 in both mouse and human lymphoma cells . Positive_regulation MMP9 LGALS7B 19885589 2161161 *Induction* of [matrix metalloproteinase-9] by through p38 MAPK signaling in HeLa human cervical epithelial adenocarcinoma cells . Positive_regulation MMP9 LGALS7B 19885589 2161162 In this report , we demonstrate that the expression of [MMP-9] was *increased* by in human cervix epithelial cells ( HeLa ) . Positive_regulation MMP9 LGALS7B 19885589 2161163 These results indicate that *increases* the expression of [MMP-9] through the p38 MAPK signaling pathway . Positive_regulation MMP9 MAP2K6 15728252 1382899 Furthermore , activation of signaling in these cells with an oncogenic mutant of Ras , RasV12 , *increased* both endogenous MMP-9 gene expression and [MMP-9] promoter activity . Positive_regulation MMP9 MAP2K6 15743030 1352216 inhibitors ( PD98059 and U0126 ) *inhibited* the production of MMP-2 , [MMP-9] and high MW uPA , and upregulated TIMPs ( TIMP-1 , TIMP-2 and TIMP-3 ) . Positive_regulation MMP9 MAP2K6 17072348 1716620 Induction of [MMP-9] by TGF-beta-ALK5 signaling *requires* but not JNK , p38 MAPK or Smad4 . Positive_regulation MMP9 MAP2K6 17316137 1699820 Interestingly , constitutive expression of a wild-type ( WT ) <-MEK> alone was also capable of inducing a low , but significant MMP-9 mRNA and protein expression but did not *cause* a further increase in [MMP-9] in response to MIF . Positive_regulation MMP9 MAP2K6 17357450 1712565 U0126,a inhibitor , could obviously *inhibit* the enhanced invasion and expression of [MMP-9] and MMP-2 of these cells induced by CsA ; Positive_regulation MMP9 MAP2K6 18834856 1981677 The specific inhibitor , U0126 , significantly *blocks* TRAIL mediated NF-kappaB activation and subsequent [MMP-9] induction . Positive_regulation MMP9 MAP2K6 19181503 2071598 On the other hand , we found that adenoviral constitutive ( Ad-CA-MEK ) significantly *increased* [MMP-9] and VEGF expression . Positive_regulation MMP9 MAP2K6 19385051 2069294 Our results also showed that basal levels of [MMP-9] expression were significantly *increased* by constitutive ( CAMEK ) overexpression . Positive_regulation MMP9 MAP2K6 19475568 2107618 RGD peptide , alphavbeta3 monoclonal antibody and MAPK kinase ( ) inhibitors ( PD98059 and U0126 ) but not RAD peptide *inhibited* the OPN induced increase of the migration and [MMP-9] up-regulation of chondrosarcoma cells . Positive_regulation MMP9 MAP2K6 19715751 2158142 Both [MMP-9] and COX-2 expression were significantly *increased* by overexpression . Positive_regulation MMP9 MAP2K6 19833163 2196209 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not affect cell growth , cell death , MMP ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly *enhanced* [MMP] ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Positive_regulation MMP9 MAP2K6 19924065 2167067 The expression of [MMP-9] was significantly *increased* by overexpression , but not by CA-Akt overexpression . Positive_regulation MMP9 MAP2K6 20545600 2308503 The inhibitor slightly reduced cell growth and caspase-3 activity in MG132 treated As4.1 cells and mildly *increased* [MMP] ( DeltaPsi ( m ) ) loss and O ( 2 ) ( *- ) level . Positive_regulation MMP9 MAP2K6 21557297 2464130 Pharmacologic inhibition of EGFR , , and PI3K kinase activity in SCC10A *reduced* phosphorylated levels of ERK-1/2 and AKT , production of [MMP-9] and sE-cad , cell migration and invasion , and expressional changes of EMT markers ( E-cadherin and N-cadherin ) induced by EGF , indicating that EGFR activation promotes cell migration and invasion via ERK-1/2 and PI3K regulated MMP-9/E-cadherin signaling pathways . Positive_regulation MMP9 MAP2K6 22310287 2719037 Most importantly , and surprisingly , inhibition *results* in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type [1-MMP] expression . Positive_regulation MMP9 MMP28 10190278 603343 Gelatinase A , collagenase 3 and [gelatinase B] may be *activated* by based mechanisms , as evidenced by both biochemical and cell based studies . Positive_regulation MMP9 MMP28 12042096 949783 Herein , we demonstrate that ( 1 ) resident brain cells secrete after mechanical injury , ( 2 ) astrocytes are the main source of MMP-9 activity , and ( 3 ) ERK and p38 MAP kinases are upregulated after mechanical injury , and *mediate* the secretion of [MMP-9] . Positive_regulation MMP9 MMP28 14575305 1156190 The inhibitors significantly improved cardiac function of LPS treated rats ( Ro 31-9790 : 38 +/- 3 , doxycycline : 51 +/- 3 mmHg*mL*min ( -1 ) ) , had no effect on the loss of MMP-2 activity , and significantly *reduced* the [MMP-9] activity in the perfusate . Positive_regulation MMP9 MMP28 14670843 1202450 Our study indicates that angiogenesis triggered by tissue ischemia requires [MMP-9] , which may be *involved* in capillary branching , a potential novel role for this that could be exploited to control angiogenesis . Positive_regulation MMP9 MMP28 15075439 1232948 [MMP-9] expression as measured via zymography in the substantia nigra was *reduced* by the inhibitor . Positive_regulation MMP9 MMP28 15530852 1332786 Both recombinant human TIMP-1 and the synthetic inhibitors , GM6001 and [MMP-2-MMP-9] *Inhibitor* III , suppressed migration of human dermal microvascular endothelial cells ( HDMVEC ) in a dose dependent fashion . Positive_regulation MMP9 MMP28 15914633 1412757 Furthermore , a synthetic inhibitor *inhibited* KCl mediated [MMP-9] upregulation , which led to a significant attenuation of KCl induced retinal damage . Positive_regulation MMP9 MMP28 16940349 1609373 Importantly , the expression of also *resulted* in upregulation of MT1-MMP and [gelatinase-B] ( MMP-9 ) and in the collagen invasive activity of A549 cells . Positive_regulation MMP9 MMP28 17075289 1638246 Glucocorticoids and flavonoids inhibited [MMP-9] production , and TIMPs and inhibitors *inhibited* the gelatinolytic activity of mast cell derived MMP-9 . Positive_regulation MMP9 MMP28 17673717 1788167 We hypothesized that increased [MMP-9] was associated with ICH induced by vascular endothelial growth factor hyperstimulation and that this effect could be *attenuated* by nonspecific inhibition . Positive_regulation MMP9 MMP28 18027151 1827847 It was noteworthy that the ras/raf/MEK/ERK pathway inhibitor PD98059 attenuated GABA induced [MMP-9] expression and that both PD98059 and inhibitors *attenuated* the GABA induced invasive activity of Caki-2 cells . Positive_regulation MMP9 MMP28 19422332 2076158 Moreover , PBMC derived fibroblast-like cells expressed high levels of [MMP-9] and MMP-12 and their migration was *inhibited* by inhibitors in a wound healing assay . Positive_regulation MMP9 MMP7 10190278 603358 Gelatinase A , collagenase 3 and [gelatinase B] may be *activated* by based mechanisms , as evidenced by both biochemical and cell based studies . Positive_regulation MMP9 MMP7 12042096 949798 Herein , we demonstrate that ( 1 ) resident brain cells secrete after mechanical injury , ( 2 ) astrocytes are the main source of MMP-9 activity , and ( 3 ) ERK and p38 MAP kinases are upregulated after mechanical injury , and *mediate* the secretion of [MMP-9] . Positive_regulation MMP9 MMP7 14575305 1156205 The inhibitors significantly improved cardiac function of LPS treated rats ( Ro 31-9790 : 38 +/- 3 , doxycycline : 51 +/- 3 mmHg*mL*min ( -1 ) ) , had no effect on the loss of MMP-2 activity , and significantly *reduced* the [MMP-9] activity in the perfusate . Positive_regulation MMP9 MMP7 14670843 1202465 Our study indicates that angiogenesis triggered by tissue ischemia requires [MMP-9] , which may be *involved* in capillary branching , a potential novel role for this that could be exploited to control angiogenesis . Positive_regulation MMP9 MMP7 15075439 1232963 [MMP-9] expression as measured via zymography in the substantia nigra was *reduced* by the inhibitor . Positive_regulation MMP9 MMP7 15530852 1332801 Both recombinant human TIMP-1 and the synthetic inhibitors , GM6001 and [MMP-2-MMP-9] *Inhibitor* III , suppressed migration of human dermal microvascular endothelial cells ( HDMVEC ) in a dose dependent fashion . Positive_regulation MMP9 MMP7 15782307 1403691 The induction of these MMPs likely contributes to tissue destruction associated with the fibrogenic process , while augmenting the *activation* of MMP-2 and [MMP-9] by MMP-3 and in XLAS . Positive_regulation MMP9 MMP7 15914633 1412772 Furthermore , a synthetic inhibitor *inhibited* KCl mediated [MMP-9] upregulation , which led to a significant attenuation of KCl induced retinal damage . Positive_regulation MMP9 MMP7 16574944 1598097 No increases in RNA levels of MMP-2 , [MMP-9] , or MMP-8 were found , but levels of , MMP-12 , and MMP-13 RNA did *increase* at 14 d . Positive_regulation MMP9 MMP7 17075289 1638261 Glucocorticoids and flavonoids inhibited [MMP-9] production , and TIMPs and inhibitors *inhibited* the gelatinolytic activity of mast cell derived MMP-9 . Positive_regulation MMP9 MMP7 17673717 1788182 We hypothesized that increased [MMP-9] was associated with ICH induced by vascular endothelial growth factor hyperstimulation and that this effect could be *attenuated* by nonspecific inhibition . Positive_regulation MMP9 MMP7 18027151 1827862 It was noteworthy that the ras/raf/MEK/ERK pathway inhibitor PD98059 attenuated GABA induced [MMP-9] expression and that both PD98059 and inhibitors *attenuated* the GABA induced invasive activity of Caki-2 cells . Positive_regulation MMP9 MMP7 19422332 2076173 Moreover , PBMC derived fibroblast-like cells expressed high levels of [MMP-9] and MMP-12 and their migration was *inhibited* by inhibitors in a wound healing assay . Positive_regulation MMP9 MMP7 20226090 2223659 Levels of , -8 and TIMP-1 decreased nearly to those of non-smokers but the levels of [MMP-9] *increased* significantly from the baseline of the same subjects at 3 months after cessation ( p = 0.009 ) with no significant decline at 6 months after cessation . Positive_regulation MMP9 MMP7 9560329 500475 TIMP-free [gelatinase B] was also *activated* by . Positive_regulation MMP9 OLFM4 23161172 2707584 Overexpression of clearly *reduced* the expression levels of integrin a1 , integrin a4 , integrin a5 , integrin a6 , and [MMP9] . Positive_regulation MMP9 OXTR 16958049 1666218 *increased* pro- and active MMP-2 and [MMP-9] , compared with healthy and burned controls and therefore accelerated remodeling . Positive_regulation MMP9 PLAT 11703174 878875 Additionally , does not *induce* [gelatinase B] release by monocytes as observed under the action of urokinase . Positive_regulation MMP9 PLAT 12438450 1016776 In vitro , *induced* [MMP-9] gene expression and protein secretion in renal interstitial fibroblasts . Positive_regulation MMP9 PLAT 16051896 1447807 *promotes* [matrix metalloproteinase-9] upregulation after focal cerebral ischemia . Positive_regulation MMP9 PLAT 16051896 1447809 These data demonstrate that *upregulates* brain [MMP-9] levels in stroke in vivo , and suggest that combination therapies targeting MMPs may improve tPA therapy . Positive_regulation MMP9 PLAT 16303771 1511112 This study investigated the mechanism by which *induces* [MMP-9] gene expression . Positive_regulation MMP9 PLAT 16303771 1511114 Blockade of Erk-1/2 activation by the Mek1 inhibitor abolished [MMP-9] *induction* by in NRK-49F cells . Positive_regulation MMP9 PLAT 16410751 1513771 Moreover , or tPA/plg *increased* the number of macrophages and induced [MMP-9] expression at the injury site , coincident with reduced collagen scar formation and accelerated clearance of myelin and lipid debris after treatment . Positive_regulation MMP9 PLAT 16741180 1576394 Reduction of *induced* [matrix metalloproteinase-9] by simvastatin in astrocytes . Positive_regulation MMP9 PLAT 16741180 1576395 Simvastatin ( 1 to 10 micromol/L ) significantly reduced *induced* [MMP-9] in cortical astrocytes . Positive_regulation MMP9 PLAT 16741180 1576397 This effect may be mediated via the Rho kinase pathway because tPA induced activation of Rho signaling was suppressed by simvastatin , and *induced* [MMP-9] levels were similarly reduced by the Rho kinase inhibitor Y-27632 ( 1 to 10 micromol/L ) . Positive_regulation MMP9 PLAT 17561000 1753398 This change correlated with increased ( tPA ) activity , and *increased* [matrix metalloproteinase-9 (MMP-9)] , but not MMP-2 activity . Positive_regulation MMP9 PLAT 18716863 2028248 These results indicate that activity may *regulate* the [MMP-9] activity in injury nerve post-CCI . Positive_regulation MMP9 PLAT 19478225 2097655 In normoxic rats , delayed treatment at 4.5 hours after stroke onset resulted in high mortality , more severe neurological deficits , increased hemorrhage volumes , and *augmented* [MMP-9] induction compared with saline . Positive_regulation MMP9 PLAT 19638998 2149982 In addition , adjuvant treatment with atorvastatin at 4 h and with tPA at 6 h reduced induced *upregulation* of protease activated receptor-1 , intercellular adhesion molecule-1 , and [matrix metalloproteinase-9] , and concomitantly reduced cerebral microvascular platelet , neutrophil , and fibrin deposition compared with rats treated with tPA alone at 6 h . Positive_regulation MMP9 PLAT 21860527 2469211 In the ischemic brain , free radicals and exogenous itself can *trigger* [MMP-9] activation through several signaling pathways containing LDL receptor related protein (LRP) and proteinase activated receptor 1 (PAR1) . Positive_regulation MMP9 PLAU 11262189 796302 system *mediated* [MMP-9] activation is implicated in bronchial epithelial cell migration . Positive_regulation MMP9 PLAU 12117412 997492 Recombinant *induced* the release of [MMP9/gelatinase] B , as detected by zymography and Western blotting , and this release was abolished by actinomycin D and cycloheximide ( inhibitors of DNA transcription and protein synthesis ) and partially suppressed by monensin ( an inhibitor of secretion ) . Positive_regulation MMP9 PLAU 12372334 996319 The cross talk between bombesin- and beta1-integrin engaged signals seems to be crucial for the modulation of both membrane linked activity and [MMP-9] *activation* and triggers complex intracellular signaling pathways requiring activation of tyrosine kinase activity , including that of src and PI3K . Positive_regulation MMP9 PLAU 12908082 1150807 Furthermore , *activates* [matrix metalloproteinase 9] which can truncate and activate IL-8 . Positive_regulation MMP9 PLAU 16554301 1562040 2 ) activation of plasminogen by and subsequent *activation* of transforming growth factor-beta1 ( TGF-beta1 ) and [matrix metalloproteinase (MMP)-2 and -9] by plasmin are critical pathways through which uPA expressing macrophages accumulate in the heart and cause fibrosis ; Positive_regulation MMP9 PLAU 16691505 1560356 Furthermore , OPN enhances NIK regulated urokinase-type plasminogen activator ( uPA ) secretion , *dependent* [pro-MMP-9] activation , and cell motility . Positive_regulation MMP9 PLAU 16926552 1615040 *Induction* of [MMP9] by in THP-1 monocytes is via a pathway involving MEK1-ERK1/2 mediated activation of cytosolic PLA2 and eicosanoid generation . Positive_regulation MMP9 PLAU 18355442 1892380 Furthermore , two active MMP-9 fragments with identical molecular weights to the *activated* [MMP-9] products were detected in GBM patient specimens . Positive_regulation MMP9 PLAU 19330806 2080419 Moreover , we found that as well as uPAR *induced* the production of VEGF and [MMP-9] , and that the down-regulation of uPA/uPAR by siRNAs or B-DIM treatment resulted in the inhibition of VEGF and MMP-9 secretion which could be responsible for the observed inhibition of cell migration . Positive_regulation MMP9 PLAU 19420329 2135743 These data showed that [MMP-9] activity was *attenuated* by a selective inhibitor , B428 . Positive_regulation MMP9 PLAU 20177776 2265243 *induces* BV-2 microglial cell migration through activation of [matrix metalloproteinase-9] . Positive_regulation MMP9 PLAU 20177776 2265245 Unlike the uPA inhibitor , plasmin inhibitor PAI-1 only partially inhibited *induced* cell migration and [MMP-9] activation . Positive_regulation MMP9 PLAU 20177776 2265246 These results suggest that plays a critical role in BV-2 microglial cell migration by *activating* [pro-MMP-9] , in part by its direct action on MMP-9 and also in part by the activation of plasminogen/plasmin cascade . Positive_regulation MMP9 PODXL 17616675 1769344 These findings suggest that leads to increased in vitro migration and invasion , *increased* [MMP] expression , and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation MMP9 S100A7 23535840 2772546 In addition , overexpression *enhanced* NF-?B mediated [matrix metalloproteinase-9 (MMP-9)] secretion in MDA-MB-231 cells indicating its role in enhanced invasiveness . Positive_regulation MMP9 SELL 9754865 535242 Ligation of and integrin CD11b/CD18 ( Mac-1 ) *induces* release of [gelatinase B] ( MMP-9 ) from human neutrophils . Positive_regulation MMP9 SPHK1 22684547 2705933 Moreover , was *required* for the production of [MMP-2/9] and uPA in tumor cells , which was suppressed by ERK1/2 inhibitor U0126 , but enhanced by the p38 MAPK inhibitor SB203580 . Positive_regulation MMP9 TGM2 18809380 1976250 The decreased mRNA levels of MMP-9 and the results of a promoter assay revealed that may be *involved* in [MMP-9] transcription . Positive_regulation MMP9 TGM2 23201552 2730748 Gene silencing of suppressed the migration and invasion of HT-1080 cells and *suppressed* the activities of MMP-2 and [MMP-9] . Positive_regulation MMP9 TGM2 24130925 2714734 Gene silencing of *suppressed* the [MMP] expression by ATRA . Positive_regulation MMP9 TLR7 16510559 1561617 To find out the molecular mechanism responsible for the suppressive effect of decursin , we analyzed signaling molecules involved in the mediated *activation* of [MMP-9] and cytokines . Positive_regulation MMP9 TLR7 18802113 1964846 IFN-gamma , which augments inflammatory cytokine production in response to macrophage activating factors such as TLR ligands , instead broadly suppressed *induced* [MMP] expression . Positive_regulation MMP9 TNF 10364303 621014 The receptor associated factor ( TRAF ) pathway also *contributed* to the activation of the [MMP-9] promoter as shown by the use of TRAF-2 and TRAF-3 dominant negative constructs . Positive_regulation MMP9 TNF 10482270 643790 We also examined the possibility that such MMPs could be produced by brain derived cells , and that [MMP] production by these cells might be *increased* by , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD . Positive_regulation MMP9 TNF 10633074 659902 Selective inhibition of p38 activity with SB 203580 abolished the *enhancement* of MMP-13 , as well as collagenase-1 ( MMP-1 ) and [92-kDa gelatinase] ( MMP-9 ) expression by and TGF- ( beta ) . Positive_regulation MMP9 TNF 10646501 661868 In contrast , [MMP-9] was *inducible* by RA , , or PMA . Positive_regulation MMP9 TNF 10864917 705858 IL-1beta and each *increased* total [matrix metalloproteinase (MMP)] activity as measured by in-gel zymography , causing specific increases in the bands corresponding to MMP-13 , MMP-2 , and MMP-9 . Positive_regulation MMP9 TNF 10943866 721466 Because matrix metalloproteinase 9 (MMP-9) is regulated by nuclear factor kappaB (NF-kappaB) , we investigated the effect of a super-repressor form of inhibitor of nuclear factor kappaBalpha ( srIkappaBalpha ) on the suppression of *induced* [MMP-9] production in acinar cells . Positive_regulation MMP9 TNF 10943866 721473 *induced* the production of [MMP-9] in the ACpRc-1 cell clone , but greatly suppressed MMP-9 production in ACMT-6 and ACMT-7 clones . Positive_regulation MMP9 TNF 10943866 721475 These observations indicate that suppression of *induced* [MMP-9] production by the introduction of srIkappaBalpha cDNA corrected the aberrant in vitro morphogenesis of acinar cells grown on type IV collagen . Positive_regulation MMP9 TNF 10967046 728288 In conjunctivochalasis fibroblasts and normal conjunctival fibroblasts , , but not IL-1beta , *induced* a gelatinolytic activity of [MMP-9] , which was further confirmed by Western blot analysis and ELISA . Positive_regulation MMP9 TNF 11014232 736347 Using a primary culture model in which rat MEC grow three-dimensionally within a reconstituted basement membrane , we found that *stimulated* secretion of [MMP-9] but not MMP-2 . Positive_regulation MMP9 TNF 11073115 748784 Fibronectin bound *stimulates* monocyte [matrix metalloproteinase-9] expression and regulates chemotaxis . Positive_regulation MMP9 TNF 11073115 748789 It is interesting that , although the adhesion of MonoMac-6 cells to FN/TNF-alpha required functional activated beta1 integrins , *induced* [MMP-9] secretion was independent of binding to beta1 integrins , since MMP-9 secretion was unaffected by : ( 1 ) neutralizing nAb to alpha4 , alpha5 , and beta1 subunits , which blocked cell adhesion ; Positive_regulation MMP9 TNF 11116048 757950 Treatment with either SB203580 ( inhibitor of p38 MAPK ) or U0126 ( inhibitor of the ERK pathway ) downregulated the *induced* [MMP-9] expression in a dose dependent manner . Positive_regulation MMP9 TNF 11132772 760233 MMP-3 ) and gelatin zymography demonstrated that *induced* [MMP-9] production in human lung fibroblast , whereas PDGF alone did not . Positive_regulation MMP9 TNF 11147175 760936 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that may *induce* [MMP] production followed by matrix degradation within foreign body granulomas . Positive_regulation MMP9 TNF 11244573 792402 Stimulation of CaCO-2 cells with interleukin-1beta (IL-1beta) or *led* to a dose dependent increase in expression and secretion of [MMP-9] . Positive_regulation MMP9 TNF 11297541 819942 In this report we demonstrate that and transforming growth factor-beta ( TGF-beta ) synergistically *induce* [pro-MMP-9] in human skin as well as isolated dermal fibroblasts and epidermal keratinocytes . Positive_regulation MMP9 TNF 11297541 819943 Furthermore , *promotes* proteolytic activation of [pro-MMP-9] by conversion of the 92-kDa pro-MMP-9 to the 82-kDa active enzyme . Positive_regulation MMP9 TNF 11310848 804859 Transforming growth factor-beta suppresses alpha *induced* [matrix metalloproteinase-9] expression in monocytes . Positive_regulation MMP9 TNF 11310848 804860 We found that TGF-beta suppressed *induced* [MMP-9] secretion by MonoMac-6 monocytic cells in a dose dependent manner , with a maximal effect of TGF-beta observed at 1 ng/ml . Positive_regulation MMP9 TNF 11310848 804861 Such suppression was likely regulated at the pretranslational level , because steady-state mRNA levels of *induced* [MMP-9] were reduced by TGF-beta , and pulse-chase radiolabeling also showed a decrease in new MMP-9 protein synthesis . Positive_regulation MMP9 TNF 11310848 804862 Suppression of *induced* [MMP-9] secretion by TGF-beta correlated with a reduction in prostaglandin E2 ( PGE2 ) secretion . Positive_regulation MMP9 TNF 11310848 804863 Furthermore , the effect of TGF-beta or indomethacin on blockage of *stimulated* [MMP-9] production was reversed by the addition of either exogenous PGE2 or the cyclic AMP ( cAMP ) analogue Bt2cAMP . Positive_regulation MMP9 TNF 11310848 804864 Thus , we concluded that TGF-beta acts as a potent suppressor of *induced* monocyte [MMP-9] synthesis via a PGE2- and cAMP dependent mechanism . Positive_regulation MMP9 TNF 11319838 806912 OST cells enhance the *induction* of [matrix metalloproteinase (MMP)-9] by and the corresponding metastasis to lungs in vivo ( Kawashima et al. , 1994 ) . Positive_regulation MMP9 TNF 11356705 815735 Additionally , stimulated the binding of nuclear factor-kappaB to a consensus kappaB-oligonucleotide , increased the stability of matrix metalloproteinase-9 (MMP-9) transcripts , and *increased* [MMP-9] activity . Positive_regulation MMP9 TNF 11404256 825286 In conclusion , *induction* by of upregulation of both the [92-kDa gelatinase] and its inhibitor TIMP-1 results in maintenance of the gelatinase-inhibitor balance , indicating that basement membrane degradation does not mediate the TNF-alpha induced increase in alveolar epithelial monolayer permeability . Positive_regulation MMP9 TNF 11404372 825437 For example , we describe our findings that tumor necrosis factor (TNF)-alpha acts as an adhesion strengthening and stop signal for T cells migrating toward stromal cell derived factor-1alpha , while transforming growth factor-beta down-regulates *induced* [matrix metalloproteinase-9] secretion by monocytes . Positive_regulation MMP9 TNF 11487146 845172 stimulated MMP-2 activity in conditioned medium and *stimulated* [MMP-9] activity with addition of plasminogen into conditioned medium . Positive_regulation MMP9 TNF 11487146 845174 The present results suggested that stimulates PA activity via an enhancement of tPA gene expression in HDP cells and MMP-2 activity , and further that tPA activated TNF-alpha *stimulated* [MMP-9] . Positive_regulation MMP9 TNF 11500442 847058 In conclusion , we show that mycobacterial infection induces [MMP-9] activity both in vitro and in vivo and that this is *regulated* by , IL-18 , and IFN-gamma . Positive_regulation MMP9 TNF 11673527 872839 Our results demonstrate that IFN-gamma and IFN-beta significantly inhibit [MMP-9] enzymatic activity and protein expression that is *induced* by PMA and the cytokine . Positive_regulation MMP9 TNF 11704541 879287 *Induction* of [MMP-9] in normal human bronchial epithelial cells by via NF-kappa B-mediated pathway . Positive_regulation MMP9 TNF 11704541 879293 We demonstrated that *induced* [MMP-9] at both the protein and mRNA levels in human bronchial epithelial cells and that interleukin-1 beta did not . Positive_regulation MMP9 TNF 11704541 879294 Increased expression of [MMP-9] and NF-kappa B activation *induced* by were inhibited by pyrrolidine dithiocarbamate and N-acetyl-L-cysteine but were not inhibited by curcumin . Positive_regulation MMP9 TNF 11704541 879298 These results suggest that *induces* the expression of [MMP-9] in human bronchial epithelial cells and that this induction is mediated via the NF-kappa B-mediated pathway . Positive_regulation MMP9 TNF 11747375 889298 Both IL-1beta and *augmented* [MMP-9] expression in HT1080 cells . Positive_regulation MMP9 TNF 11753501 890124 Among these we identified two oncogene products ( Jun and Fos ) which were activated by or phorbol esters and which *promoted* the synthesis of [MMP-9] . Positive_regulation MMP9 TNF 11773040 899413 Isolated RMVECs did not significantly increase [MMP] production directly in response to a hypoxic stimulus , but *required* the presence of exogenous . Positive_regulation MMP9 TNF 11773040 899416 *increased* the expression of MT1-MMP , MMP-3 , and [MMP-9] in these cells . Positive_regulation MMP9 TNF 11781293 900304 Trypsin , interleukin 1 beta , and all potently *stimulated* [MMP-9] release from PMN . Positive_regulation MMP9 TNF 11813159 907413 Chemokine stimulation of monocyte [matrix metalloproteinase-9] *requires* endogenous . Positive_regulation MMP9 TNF 11825017 892931 Semi-quantitative RT-PCR and Northern hybridization disclosed that the [MMP-9] transcript was also markedly *up-regulated* in a dose dependent manner by IL-1beta and . Positive_regulation MMP9 TNF 12004062 962036 The mediated *activation* of [pro-MMP-9] was tightly associated with down-regulation of tissue inhibitor of metalloproteinase-1 in a dose dependent manner . Positive_regulation MMP9 TNF 12105194 984533 Interferons inhibit mediated [matrix metalloproteinase-9] *activation* via interferon regulatory factor-1 binding competition with NF-kappa B . Positive_regulation MMP9 TNF 12105194 984539 ( i ) IFN treatment suppresses *induced* [MMP-9] reporter activity in STAT1 ( +/+ ) cells but not in STAT1 ( -/- ) cells . Positive_regulation MMP9 TNF 12113550 963877 Because elevation of COX-2 mRNA levels enhances the production of prostaglandins , we therefore investigated whether endogenous prostaglandins are involved in the [MMP] mRNA expression that is *enhanced* by . Positive_regulation MMP9 TNF 12115190 964088 Our previous results suggested that suppression of *induced* [matrix metalloproteinase 9 (MMP-9)] could prevent the destruction of acinar tissue in the salivary glands of patients with Sjögren 's syndrome ( SS ) . Positive_regulation MMP9 TNF 12115190 964089 The present study was undertaken to investigate the effect of cepharanthine on the suppression of *induced* [MMP-9] production in NS-SV-AC , an SV40 immortalized normal human acinar cell clone . Positive_regulation MMP9 TNF 12115190 964091 Although *induced* the production of [MMP-9] in NS-SV-AC cells , this production was greatly suppressed when cells were pretreated with cepharanthine , followed by treatment with both TNFalpha and cepharanthine . Positive_regulation MMP9 TNF 12200127 982732 Here , we report that PI 3-kinase inhibits [MMP-9] expression *induced* by either IL-1 or in rat C6 glioma cells . Positive_regulation MMP9 TNF 12200127 982736 In contrast , platelet derived growth factor ( PDGF ) , an inducer of PI 3-kinase activity in C6 cells , inhibited IL-1- or *induced* [MMP-9] secretion . Positive_regulation MMP9 TNF 12200127 982737 Furthermore , stable C6 clones over expressing the dominant negative form the regulatory subunit of PI 3-kinase potentiated the expression of [MMP-9] *induced* by IL-1 or . Positive_regulation MMP9 TNF 12456593 1021289 All pro-inflammatory cytokines enhanced MT1-MMP expression and IL-4 suppressed *induced* [MMP-9] expression . Positive_regulation MMP9 TNF 12475184 1023530 The solution of Abeta ( 5 microM ) formed by 2-h incubation at room temperature induced tumour necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 levels by 55 and 45 % , respectively , and *increased* [gelatinase B] activity by 67 % , while exposure of cells to the ACT/Abeta1-42 mixture ( 1 : 10 molar ratio ACT : Abeta1-42 ) under the same experimental conditions showed no effect on IL-6 levels or gelatinase B activity , but strongly induced ( by 190 % ) , compared to the controls . Positive_regulation MMP9 TNF 12488366 1033083 Furthermore , induced the expression of Sertoli cell collagen alpha3 ( IV ) , gelatinase B ( matrix metalloprotease-9 , MMP-9 ) and tissue inhibitor of metalloproteases-1 but not gelatinase A ( matrix metalloprotease-2 ) , and *promoted* the activation of [pro-MMP-9] . Positive_regulation MMP9 TNF 12488366 1033084 These results thus suggest that the activated [MMP-9] *induced* by is used to cleave the existing collagen network in the ECM , thereby perturbing the TJ-barrier . Positive_regulation MMP9 TNF 12506073 1038360 Both IL-4 and -13 significantly decreased production of MMP-1 and increased that of TIMP-1 , whereas *increased* production of [MMP-1 and -9] . Positive_regulation MMP9 TNF 12589822 1059986 Quercetin inhibited *induced* [MMP-9] secretion on HASMC in a dose dependent manner . Positive_regulation MMP9 TNF 12606436 1064595 Membrane type-1 [MMP] mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation MMP9 TNF 12616343 1065624 [MMP-9] production was *dependent* on endogenous production of , as detected by use of neutralizing monoclonal antibodies . Positive_regulation MMP9 TNF 12616541 1065718 Soluble glucocorticoid induced receptor ( sGITR ) *increased* [MMP-9] activity in murine macrophage . Positive_regulation MMP9 TNF 12745093 1088575 Moreover , the [MMP-9] *induction* by HGF and was also completely inhibited by GF109203X and sulfasalazine , but not by PD98059 and U0126 . Positive_regulation MMP9 TNF 12898704 1118590 But in this case , all three MAP kinase inhibitors ( U0126 , SB203580 , and SP600125 ) reduced *induced* [MMP-9] upregulation . Positive_regulation MMP9 TNF 12909329 1121961 *mediates* the stretch induced [MMP] genes expression , at least in part , through the JNK pathway . Positive_regulation MMP9 TNF 12960156 1158196 In contrast to its effects on MMP-1 , IFNgamma inhibited *induced* [MMP-9] through a caspase 8-dependent pathway as demonstrated by the restoration of MMP-9 with caspase 8 inhibitors . Positive_regulation MMP9 TNF 13679081 1140272 [Matrix metalloproteinase-9 (MMP-9)] expression was also increased in *response* to in aged MASMC , as evidenced by zymography and immunoblot analysis . Positive_regulation MMP9 TNF 13679081 1140274 In addition , the transcription factors NF-kappaB and AP-1 that are involved in the [MMP-9] regulation of aged MASMC in *response* to were identified by means of mutation analysis and gel shift assays . Positive_regulation MMP9 TNF 14516792 1147196 The inhibition of MAPK pathway is correlated with down-regulation of [MMP-9] secretion *induced* by in human keratinocytes . Positive_regulation MMP9 TNF 14516792 1147197 Since the invasive phenotype of cancers is dependent on MMP-9 expression , it appeared of interest to precisely characterize which signal transduction pathways activated by TNF-alpha are involved in [MMP-9] up-regulation *induced* by . Positive_regulation MMP9 TNF 14516792 1147211 As TNF-alpha is known to be a main activator of NF-kappaB pathway , the effects of campthothecin and caffeic acid were investigated , such as , TNF-alpha campthothecin up-regulated MMP-9 activity but caffeic acid only weakly inhibited [MMP-9] activation *induced* by . Positive_regulation MMP9 TNF 14607966 1162178 Conversely , directly *stimulated* dose dependent [MMP-9] secretion . Positive_regulation MMP9 TNF 14630924 1201133 Flavopiridol also inhibited the expression of the *induced* NF-kappaB regulated gene products cyclin D1 , cyclooxygenase-2 , and [matrix metalloproteinase-9] . Positive_regulation MMP9 TNF 14673992 1178654 The in vivo data clearly indicated that OSM + overexpression *increased* [MMP] levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) . Positive_regulation MMP9 TNF 14734780 1199525 Ets-1 regulates *induced* [matrix metalloproteinase-9] and tenascin expression in primary bronchial fibroblasts . Positive_regulation MMP9 TNF 14755547 1205629 ERK1/2 mediates *induced* [matrix metalloproteinase-9] expression in human vascular smooth muscle cells via the regulation of NF-kappaB and AP-1 : Involvement of the ras dependent pathway . Positive_regulation MMP9 TNF 14755547 1205630 *stimulated* the secretion of [MMP-9] in HASMC , as shown by zymography and immunoblot analysis . Positive_regulation MMP9 TNF 14755547 1205631 At the transcriptional levels , also *stimulated* the 5'-flanking 710-bp promoter activity of [MMP-9] . Positive_regulation MMP9 TNF 14755547 1205632 Treatment with U0126 , an inhibitor of the extracellular signal regulated kinase ( ERK ) , significantly downregulated *induced* [MMP-9] expression and promoter activity , whereas the inactive analog U0124 had no effect . Positive_regulation MMP9 TNF 14755547 1205638 Finally , the transient transfection of HASMC with dominant negative Ras ( RasN17 ) suppressed *induced* ERK activity , [MMP-9] production , and promoter activity . Positive_regulation MMP9 TNF 14755547 1205644 In addition , the transcription factors NF-kappaB and AP-1 that are involved in the Ras/ERK mediated control of [MMP-9] regulation on HASMC in *response* to have now been identified . Positive_regulation MMP9 TNF 14766231 1207552 *induced* rapid and robust [pro-MMP-9] release from eosinophils . Positive_regulation MMP9 TNF 14766231 1207553 Using pharmacological inhibitors , we found that *stimulated* [MMP-9] release was mediated by p38 MAP kinase , but not Erk-1/2 . Positive_regulation MMP9 TNF 14967948 1182641 Both and TNF-beta strongly *stimulated* the production of MMP-2 and [MMP-9] , whereas IGFs had no effect . Positive_regulation MMP9 TNF 14973065 1212315 Amiloride , an uPA inhibitor , not only inhibited the activity of uPA but was also able to suppress *stimulated* [MMP-9] activity and prevented the TNF-alpha stimulated remodeling of the basement membrane extracellular matrix , suggesting the contribution of uPA mediated proteolytic cascade in this process . Positive_regulation MMP9 TNF 14978741 1213649 Furthermore , we show that is able to *enhance* considerably the [MMP-9] promoter activity only in tumor cells . Positive_regulation MMP9 TNF 14984207 1214665 Expression of PTEN also led to the inhibition of *induced* [matrix metalloproteinase-9 (MMP-9)] expression in VSMC as determined by zymography and immunoblot . Positive_regulation MMP9 TNF 14998513 1216642 strongly *induced* [pro-MMP-9] . Positive_regulation MMP9 TNF 15044327 1272771 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to dependent [MMP] *induction* in the macrophages . Positive_regulation MMP9 TNF 15111578 1241194 Retinal homogenate challenge reduced the total amount of active MMP-2 produced , and *stimulated* [MMP-9] production . Positive_regulation MMP9 TNF 15175338 1273491 The expression of the GD3 synthase gene also led to the inhibition of *induced* [matrix metalloproteinase-9 (MMP-9)] expression in VSMC as determined by zymography and immunoblot . Positive_regulation MMP9 TNF 15175354 1267805 Nevertheless , *induced* [MMP9] expression , secretion , and enzymatic activity of beige , LDLr-/- macrophages were all significantly decreased compared with those of LDLr-/- macrophages ( P < 0.05 ) . Positive_regulation MMP9 TNF 15184206 1280587 *causes* increased [MMP] production , but some increased MMP activity is present even in TNFRKO mice . Positive_regulation MMP9 TNF 15201935 1260878 IL-1 and are potent *inducers* of [matrix metalloproteinases (MMP)] , eicosanoids , nitric oxide oxydase ( iNOS ) , receptor activator of NF-kB ligand ( RANKL ) , products involved in the destruction of the extracellular matrix , the cartilage and in bone resorption . Positive_regulation MMP9 TNF 15273742 1296417 *regulates* epithelial expression of [MMP-9] and integrin alphavbeta6 during tumour promotion . Positive_regulation MMP9 TNF 15273742 1296421 Mice deficient in ( TNF-alpha ( -/- ) mice ) are resistant to skin carcinogenesis and expression of [MMP-9] is *inhibited* in TNF-alpha ( -/- ) mice during skin tumour development . Positive_regulation MMP9 TNF 15273742 1296423 Furthermore , alphavbeta6 blockade significantly inhibited keratinocyte migration and *stimulated* [MMP-9] expression in vitro . Positive_regulation MMP9 TNF 15380733 1298521 In this study , we investigated the inhibitory effect of CDS on *induced* human aortic smooth muscle cells ( HASMC ) migration and [MMP-2 and -9] activity . Positive_regulation MMP9 TNF 15458430 1301529 but not IL-1beta *resulted* in a dose dependent increase in the latent form of [MMP-9] . Positive_regulation MMP9 TNF 15458430 1301533 Activation of the extracellular signal regulated protein kinase ( ERK1/2 ) MAPK mediated the up-regulation of MMP-9 by TNF-alpha whereas p38 was found to be involved in the IL-1beta mediated inhibition of *stimulated* [MMP-9] . Positive_regulation MMP9 TNF 15528190 1360038 Cyclin dependent kinase 9 is required for *stimulated* [matrix metalloproteinase-9] expression in human lung adenocarcinoma cells . Positive_regulation MMP9 TNF 15528190 1360041 This study investigated roles of CDK9 in *stimulated* [MMP-9] expression in human lung adenocarcinoma cells . Positive_regulation MMP9 TNF 15528190 1360044 All three approaches reduced *mediated* accumulation of [MMP-9] in the conditioned media as demonstrated by gelatin zymography . Positive_regulation MMP9 TNF 15528190 1360050 Our findings indicate that CDK9 mediates *induced* [MMP-9] transcription . Positive_regulation MMP9 TNF 15537504 1336502 Simvastatin ( 0.1-10 mumol/l ) concentration dependently inhibited *induced* myofibroblast proliferation , invasion and [MMP-9] secretion . Positive_regulation MMP9 TNF 15537504 1336503 , acting predominantly via the TNF-R1 receptor , *increased* human atrial myofibroblast proliferation , invasion and [MMP-9] secretion , all of which were inhibited by simvastatin . Positive_regulation MMP9 TNF 15605368 1387575 BITC inhibited *induced* [MMP-9] secretion in VSMC in a dose dependent manner . Positive_regulation MMP9 TNF 15648090 1402304 We also observed that PMA and *stimulated* [matrix metalloproteinase-9] secretion , whereas IL-1beta and P. gingivalis LPS did not . Positive_regulation MMP9 TNF 15661925 1365125 However , signaling is not *required* for AQARSAASKVKVSMKF induced PMN release of [MMP-9] or PMN emigration . Positive_regulation MMP9 TNF 15699164 1372507 also *up-regulated* microglial release of [matrix metalloproteinase-9 (MMP-9)] , an enzyme with potential neurotoxic properties that is transcriptionally regulated by NF-kappaB . Positive_regulation MMP9 TNF 15699164 1372508 These findings suggest that PARP-1 activation is required for both TNF-alpha induced microglial activation and the neurotoxicity resulting from *induced* [MMP-9] release . Positive_regulation MMP9 TNF 15708369 1372965 Zymographic and immunoblot analyses showed that EGCG suppressed *induced* [MMP-9] expression in a dose dependent manner . Positive_regulation MMP9 TNF 15723721 1376757 Pretreatment of cells with anti-TNFR2 neutralizing antibody inhibited the *dependent* signaling and [MMP-9] secretion and subsequently blocked invasion in vitro . Positive_regulation MMP9 TNF 15780956 1385426 In vitro assessment of cultured fracture callus cells in comparison to primary articular chondrocytes showed that treatment specifically *induced* the expression of [MMP9] , MMP14 , VEGI , and Angiopoietin 2 . Positive_regulation MMP9 TNF 16012040 1431589 *stimulated* [MMP-9] secretion in both cell lines , but only stimulated MMP-1 secretion in one ( UT-SCC-24A ) . Positive_regulation MMP9 TNF 16079290 1442666 *induced* the expression of [matrix metalloproteinase 9 (MMP-9)] . Positive_regulation MMP9 TNF 16140265 1454778 A small compound that inhibits *induced* [matrix metalloproteinase-9] upregulation . Positive_regulation MMP9 TNF 16140265 1454780 We identified a novel synthetic compound that inhibits *induced* [MMP-9] upregulation in the HT1080 human fibrosarcoma cell line . Positive_regulation MMP9 TNF 16140265 1454781 The active compound SM-7368 inhibited *induced* [MMP-9] upregulation in a concentration dependent manner and showed maximal activity at 10 microM . Positive_regulation MMP9 TNF 16140265 1454782 SM-7368 inhibited *induced* [MMP-9] mRNA transcript accumulation and protein expression . Positive_regulation MMP9 TNF 16140265 1454788 Taken together , our results demonstrate that SM-7368 is a synthetic compound that inhibits *induced* [MMP-9] expression , and thus SM-7368 should be useful for the development of chemotherapies targeting TNF-alpha mediated tumor invasion and metastasis . Positive_regulation MMP9 TNF 16148153 1455151 Chondrocytes and synoviocytes , the resident cells of joint capsule , markedly increase transcription of [MMP-9] in *response* to IL-1beta- and mediated stimulation . Positive_regulation MMP9 TNF 16272296 1479299 In turn , *enhances* synthesis of [MMP-9] in monocytes . Positive_regulation MMP9 TNF 16272296 1479300 [MMP-9] activation was specific for trophozoite/hemozoin fed monocytes , was *dependent* on production , and abrogated by anti-TNF-alpha Ab and by a specific inhibitor of MMP-9/MMP-13 activity . Positive_regulation MMP9 TNF 16275891 1502463 We examined the pathways that regulate *mediated* [MMP-9] release and found this to be dependent on the TNF receptor I . TNF rapidly activated extracellular signal regulated kinase and p38 mitogen activated protein kinases , but neither of these pathways was critical for MMP-9 release . Positive_regulation MMP9 TNF 16275891 1502465 Similarly , blocking Src family kinases with the inhibitor PP2 only attenuated *induced* [MMP-9] release . Positive_regulation MMP9 TNF 16303143 1546885 Stimulation of human HSCs , LI90 cells , with *caused* the induction of [pro-MMP-9] . Positive_regulation MMP9 TNF 16317118 1487598 Furthermore , zymographic and immunoblot analyses showed that RV dose dependently suppressed the *induced* expression of [MMP-9] . Positive_regulation MMP9 TNF 16350852 1492419 MAP kinase activation is required for the [MMP-9] *induction* by . Positive_regulation MMP9 TNF 16350852 1492421 But neither p38 MAP kinase nor JNK inhibitor had an effect on TNF-alpha induced MMP-9 expression , suggesting that ERK activation is required for the [MMP-9] *induction* by . Positive_regulation MMP9 TNF 16376111 1553940 The NF-kappaBp65-specific siRNA inhibited the expression of NF-kappaBp65 and activation of NF-kappaB , reducing significantly the expression of COX-2 , NOS-2 and [MMP-9] *induced* by interleukin-1beta (IL-1beta) and in cultured chondrocytes . Positive_regulation MMP9 TNF 16434697 1540479 *induced* [MMP-9] transcription by threefold , but no significant difference was observed in MMP-9 mRNA steady-state between normoxia and hypoxia , which inhibited the trafficking of proMMP-9 via secretory vesicles and increased the intracellular accumulation of proMMP-9 in the cells by 47 % and 62 % compared with normoxia ( P < 0.05 ) , as evaluated by zymography of cellular extracts and confocal microscopy , respectively . Positive_regulation MMP9 TNF 16465063 1495675 Simvastatin suppressed MMP-9 at both the mRNA and protein levels as well as at the urokinase-type plasminogen activator protein level , resulting in the dramatic suppression of [MMP-9] activity *induced* by . Positive_regulation MMP9 TNF 16497166 1528792 Modulation of autocrine *stimulated* [matrix metalloproteinase 9 (MMP-9)] expression by mitogen activated protein kinases in THP-1 monocytic cells . Positive_regulation MMP9 TNF 16497166 1528793 Moreover , exogenously added *augmented* [MMP-9] synthesis and secretion in THP-1 cells via enhancement of ERK1/2 activity . Positive_regulation MMP9 TNF 16497166 1528794 Taken together , our results indicate that ERK1/2 activity plays a pivotal role in *induced* [MMP-9] production and demonstrate its negative modulation by p38 and JNK activity . Positive_regulation MMP9 TNF 16520344 1555067 Involvement of MAPK pathway in *induced* [MMP-9] expression in human trophoblastic cells . Positive_regulation MMP9 TNF 16549372 1582268 and OSM induced a pronounced *increase* in [matrix metalloproteinase (MMP)] activity , which was strongly inhibited by calcitonin . Positive_regulation MMP9 TNF 16580738 1562459 NPCs ' gelatinase activities of MMP-2 and [MMP-9] , as determined by zymography , were *increased* by , and to a lesser extent by IFN-gamma . Positive_regulation MMP9 TNF 16580738 1562465 IFN-beta suppressed the *induced* levels of secreted [MMP-9] and MMP-2 , while enhancing the expression of TIMP-1 and TIMP-2 mRNA . Positive_regulation MMP9 TNF 16603966 1545152 Stimulation with *induced* secretion of [MMP-9] and increased the secretion of MMP-2 . Positive_regulation MMP9 TNF 16624086 1551776 The gene expression level of [MMP-9] *induced* by was detected by semi-quantitative RT-PCR , and MMP-9 activity was measured by zymography . Positive_regulation MMP9 TNF 16624086 1551778 The expression and activity of [MMP-9] can be *induced* by , and the induction was possibly related with the NF-kappaB mediated signal transduction pathway . Positive_regulation MMP9 TNF 16652422 1558281 Our previous study suggested that suppression by cepharanthin of *induced* [matrix metalloproteinase-9 (MMP-9)] could prevent destruction of the acinar structure in the salivary glands of patients with Sjögren 's syndrome ( SS ) . Positive_regulation MMP9 TNF 16689658 1560316 In this study , interleukin-1beta (IL-1beta) and , commonly elevated in chronic C hepatitis , *stimulate* the production of [matrix metalloprotease-9 (MMP-9)] by human hepatocytes at a transcriptional and translational level , but the addition of recombinant interferon-alpha2b ( rIFN-alpha2b ) hampers this effect . Positive_regulation MMP9 TNF 16718267 1565260 In addition , both and interleukin-1beta are strong *inducers* of active [matrix metalloproteinase-9] in vertical growth phase melanoma cell lines , indicating a possible role of these cytokines in the switch from radial growth phase to vertical growth phase . Positive_regulation MMP9 TNF 16720925 1565342 PMA and , with increased concentration , *increased* [MMP-9] secretion , while IL-1beta and LPS did not significantly modify MMP-9 activity . Positive_regulation MMP9 TNF 16787167 1577472 and IL-1beta *stimulate* macrophages to produce matrix metalloproteinase-9 [ [MMP-9] ] , and bronchial epithelial cells to produce extracellular matrix glycoproteins . Positive_regulation MMP9 TNF 16795041 1638512 OC inhibited *induced* [MMP-9] secretion on HASMC in a dose dependent manner . Positive_regulation MMP9 TNF 16816895 1646005 After infection , mRNA levels *increased* rapidly to a peak on day one , and then trypsin I and [matrix metalloproteinase (MMP)-9] , but not MMP-2 , were significantly up-regulated with a peak on day 2 in vivo . Positive_regulation MMP9 TNF 16818654 1581254 A role for focal adhesion kinase signaling in *dependent* [matrix metalloproteinase-9] production in a cholangiocarcinoma cell line , CCKS1 . Positive_regulation MMP9 TNF 16818654 1581255 We investigated the role of focal adhesion kinase ( FAK ) in *dependent* production of [MMP-9] in CCKS1 and FAK-null mouse fibroblast cells . Positive_regulation MMP9 TNF 16818654 1581257 stimulation of CCKS1 or wild-type fibroblasts substantially activated FAK phosphorylation and *increased* [MMP-9] production . Positive_regulation MMP9 TNF 16818654 1581258 Conditional expression of wild-type FAK in FAK-null cells restored the *dependent* production of [MMP-9] . Positive_regulation MMP9 TNF 16818654 1581260 In addition , small interfering RNA against FAK drastically suppressed the *dependent* production of [MMP-9] and inhibited the TNF-alpha dependent invasion of CCKS1 . Positive_regulation MMP9 TNF 16818654 1581262 Taken together , our results suggest the pivotal role of FAK in *dependent* production of [MMP-9] and subsequent activation of tumor invasion . Positive_regulation MMP9 TNF 16844724 1600226 We found that *stimulates* [MMP-9] secretion in transitional cells , whereas IFNs suppress MMP-9 secretion in immature cells . Positive_regulation MMP9 TNF 16867053 1592825 We found that selective activation of PAR-2 using the peptide SLIGKV augmented *induced* [MMP-9] protein levels and increased ERK phosphorylation . Positive_regulation MMP9 TNF 16867053 1592827 These data suggest that German cockroach frass contains active serine proteases which augment *induced* [MMP-9] expression by a mechanism involving PAR-2 , ERK and AP-1 . Positive_regulation MMP9 TNF 16924232 1692193 *induced* the expression of NF-kappaB regulated gene products cyclin D1 , c-Myc , [matrix metalloproteinase-9] , survivin , X-linked inhibitor-of-apoptosis protein ( IAP ) , IAP1 , Bcl-x ( L ) , A1/Bfl-1 and Fas associated death domain protein-like IL-1beta converting enzyme-inhibitory protein in wild-type MEF but not in PKR-/- cells . Positive_regulation MMP9 TNF 16966323 1639864 In addition , increased secretion of , interleukin (IL)-1beta , and IL-6 *induced* [pro-MMP-9] secretion and synthesis in AM1 or SS1 strain infected mice suggesting elicitation of pro-inflammatory cytokines by both cag- and cag+ genotype . Positive_regulation MMP9 TNF 16999937 1647265 Cryptotanshinone from Salvia miltiorrhiza BUNGE has an inhibitory effect on *induced* [matrix metalloproteinase-9] production and HASMC migration via down-regulated NF-kappaB and AP-1 . Positive_regulation MMP9 TNF 17038510 1674582 Furthermore , we observed an intracellular accumulation of the NF-kappaB inhibitor , IkappaBbeta , with chronic treatment with HIV-PIs or lactacystin as well as a decrease in [MMP-9] expression *induced* by acute stimulation . Positive_regulation MMP9 TNF 17052690 1636334 Wogonin suppresses *induced* [MMP-9] expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells . Positive_regulation MMP9 TNF 17052690 1636335 In this study , we examined the inhibitory effect of three major flavonoids in Scutellariae Radix , baicalin , baicalein , and wogonin , on *induced* [MMP-9] expression in human aortic smooth muscle cells ( HASMC ) . Positive_regulation MMP9 TNF 17052690 1636336 Wogonin , but not baicalin and baicalein , significantly and selectively suppressed *induced* [MMP-9] expression in HASMC . Positive_regulation MMP9 TNF 17062332 1637237 To investigate the regulatory effects of fenofibrate on *induced* CD40 expression and [matrix metalloproteinase (MMP)] activity in human vascular endothelial cells ( HUVECs ) . Positive_regulation MMP9 TNF 17062332 1637245 Fenofibrate reduces *induced* increment of CD40 expression and MMP-2 and [MMP-9] activities in HUVECs . Positive_regulation MMP9 TNF 17072979 1637772 The [MMP-9] activity was also *up-regulated* by in epithelial intestinal cells ( 2.5+/-0.5 vs 14.7+/-3.0 , P < 0.05 ) . Positive_regulation MMP9 TNF 17079649 1684066 IL-1beta and are *necessary* but not sufficient for such induction of astrocyte [MMP-9] secretion . Positive_regulation MMP9 TNF 17114644 1724518 Ascofuranone also inhibits the protein expression and transcription of [MMP-9] *induced* by . Positive_regulation MMP9 TNF 17158602 1701111 *induces* [MMP-9] expression via activation of Src/EGFR , PDGFR/PI3K/Akt cascade and promotion of NF-kappaB/p300 binding in human tracheal smooth muscle cells . Positive_regulation MMP9 TNF 17158602 1701119 In human tracheal smooth muscle cells , *induced* [MMP-9] expression and Akt phosphorylation in a time dependent manner , which was attenuated by the inhibitors of Src ( PP1 ) , epidermal growth factor receptor ( AG1478 ) , PDGFR ( AG1296 ) , and PI3K ( LY294002 ) , respectively , revealed by reporter gene assay , RT-PCR , zymographic , and Western blot analyses . Positive_regulation MMP9 TNF 17186550 1724628 Analysis of *induced* phosphorylation and [MMP-9] promoter recruitment of the p65 NFkappaB subunit revealed a significant reduction in p65 phosphorylation as well as reduced and altered recruitment of p65 to the MMP-9 gene promoter in the mutants compared to the parental RKO cell line . Positive_regulation MMP9 TNF 17186550 1724629 Our results suggest that *dependent* induction of [MMP-9] gene expression is tightly regulated by oscillatory/cumulative activation of NFkappaB and that 5-Fu stimulates NFkappaB and RKO CRC cell survival through induction of IKK activity . Positive_regulation MMP9 TNF 17242183 1710038 In this study , we show that FoxO4 activates transcription of the [MMP9] gene in *response* to signaling . Positive_regulation MMP9 TNF 17327485 1740884 We showed that in human monocytes , the proinflammatory cytokine *induced* [MMP-9] secretion and increased fragmentation of FN into distinct fragments . Positive_regulation MMP9 TNF 17357478 1665122 The presents study suggested that the expression and activity of [MMP-9] from AM can be *induced* by , and TNF-alpha/NF-kappaB signal pathway may play an important role in the induction . Positive_regulation MMP9 TNF 17394781 1721063 In addition , *induced* [MMP-9] activity was reduced by the treatment of saxatilin . Positive_regulation MMP9 TNF 17430359 1724111 We examined the effect of cysLTs ( LTC4 , -D4 and -E4 ) on *induced* [MMP-9] production in THP-1 cells , a human monocytic leukaemia cell line and peripheral blood CD14+ monocytes/macrophages . Positive_regulation MMP9 TNF 17430359 1724112 In addition , we examined the effect of pranlukast , a cysLT1 receptor antagonist , on the enhancement of *induced* [MMP-9] production by cysLTs . Positive_regulation MMP9 TNF 17430359 1724113 ELISA revealed that LTC4 and -D4 , but not -E4 , enhanced *induced* [MMP-9] production in THP-1 cells and peripheral blood CD14+ monocytes/macrophages . Positive_regulation MMP9 TNF 17430359 1724114 Real-time polymerase chain reaction demonstrated that LTC4 and -D4 , but not -E4 , increased [MMP-9] mRNA expression *induced* by in THP-1 cells . Positive_regulation MMP9 TNF 17430359 1724115 Moreover , we demonstrated that pranlukast completely inhibited the enhancement of *induced* [MMP-9] production by LTC4 and -D4 in THP-1 cells and peripheral blood CD14+ monocytes/macrophages . Positive_regulation MMP9 TNF 17430359 1724116 LTC4 and -D4 enhanced the *induced* [MMP-9] production via binding the cysLT1 receptor in human monocytes/macrophages . Positive_regulation MMP9 TNF 17469134 1737544 OSM and *stimulated* [MMP] expression as visualized by zymography , and MMP expression was dose-dependently inhibited by forskolin and IBMX . Positive_regulation MMP9 TNF 17507431 1791871 Moreover , [MMP] activity in PCPEC supernatants was significantly *increased* by , presumably due to a diminished expression of TIMP-3 that was similarly observed . Positive_regulation MMP9 TNF 17560598 1767652 Quantitative RT-PCR revealed that *induced* [MMP-9] mRNA expression was substantially reduced by pharmacological inhibitors of the ERK-1/2 , PI-3-kinase and NF-kappaB pathways . Positive_regulation MMP9 TNF 17561941 1767666 and inhibition *reduced* both PMN derived [MMP-9] activity and ROS in PMN cultures . Positive_regulation MMP9 TNF 17570325 1753752 In addition to G1 cell cycle arrest and growth inhibition in VSMC , magnolol also caused the strong inhibition of *induced* [matrix metalloproteinase-9 (MMP-9)] expression in a dose dependent manner as determined by zymography and immunoblot . Positive_regulation MMP9 TNF 17575075 1792296 was *necessary* but not sufficient for [MMP-9] up-regulation by the monocyte-epithelial cell network . Positive_regulation MMP9 TNF 17640082 1787644 The functional activity of R-ODN to inhibit NF-kappaB in vitro was evaluated in human aortic smooth muscle cells ( VSMC ) : *induced* proliferation rate and [MMP-9] expression were assessed after R-ODN transfection . Positive_regulation MMP9 TNF 17640082 1787645 Transfection of R-ODN significantly inhibited the expression of [MMP-9] *induced* by in VSMC as assessed by real-time polymerase chain reaction ( PCR ) , and R-ODN also inhibited the proliferation of VSMC induced by TNF-alpha ( 10 ng/ml ) , similar to phosphorothioate decoy ODN . Positive_regulation MMP9 TNF 17669387 1805311 Gelatin zymography , reporter gene , electrophoretic mobility shift and Western blotting assays showed that dicumarol , but not other coumarin derived anticoagulants , inhibited TNF-alpha induced HASMC migration and suppressed *induced* [matrix metalloproteinase (MMP)-9] expression and secretion in a dose dependent manner . Positive_regulation MMP9 TNF 17669387 1805312 In addition , down-regulation of NQO1 by transfection of its small interfering RNA similarly inhibited *induced* [MMP-9] secretion , indicating that dicumarol mediated inhibition of MMP-9 expression is due in large part to inhibition of NQO1 . Positive_regulation MMP9 TNF 17704356 1806021 *induced* a significant up-regulation of [gelatinase B] ( MMP-9 ) , stromelysin-1 ( MMP-3 ) , and COX-2 . Positive_regulation MMP9 TNF 17763449 1801861 Furthermore , APC directly suppressed the production of tumor necrosis factor (TNF) and the activation of NF-kappaB and MAP kinase p38 , and inhibitors of NF-kappaB or p38 reduced the production of MMP-9 , suggesting that APC *inhibits* [MMP-9] by blocking , NF-kappaB , and p38 . Positive_regulation MMP9 TNF 17876544 1796358 A similar augmentation was also observed in *induced* cytokine and [MMP] secretion . Positive_regulation MMP9 TNF 17890880 1811213 but not IL-1 beta *resulted* in a dose dependent increase in the latent form of [MMP-9] and a decrease in TIMP-1 production . Positive_regulation MMP9 TNF 17890880 1811243 p38 MAPK activation was also found to be involved in the *stimulated* [MMP-9] . Positive_regulation MMP9 TNF 17890880 1811245 The cytokine *causes* different effects on human mesangial [MMP-9] and TIMP-1 expression which are mediated through the TNF-RI , and the different signalling pathways of PKC , ERK 1/2 and p38 MAPK . Positive_regulation MMP9 TNF 17897957 1824005 *augments* [matrix metalloproteinase-9] production in skeletal muscle cells through the activation of transforming growth factor-beta activated kinase 1 ( TAK1 ) -dependent signaling pathway . Positive_regulation MMP9 TNF 17897957 1824006 Using microarray , quantitative PCR , Western blotting , and zymography , we found that drastically *increases* the production of [matrix metalloproteinase (MMP)-9] from C2C12 myotubes . Positive_regulation MMP9 TNF 17897957 1824007 Although TNF-alpha activated all the three MAPKs ( i.e. ERK1/2 , JNK , and p38 ) , inhibition of ERK1/2 or p38 but not JNK blunted the *induced* production of [MMP-9] from myotubes . Positive_regulation MMP9 TNF 17897957 1824008 Inhibition of Akt also inhibited the *induced* production of [MMP-9] . Positive_regulation MMP9 TNF 17897957 1824015 Overexpression of a dominant negative inhibitor of NF-kappaB or AP-1 blocked the *induced* expression of [MMP-9] in myotubes . Positive_regulation MMP9 TNF 17897957 1824020 Furthermore , overexpression of a dominant negative mutant of TAK1 blocked the *induced* expression of [MMP-9] and activation of NF-kappaB and AP-1 . Positive_regulation MMP9 TNF 17897957 1824029 Our results also suggest that *induces* [MMP-9] expression in muscle cells through the recruitment of TRAF-2 , Fas associated protein with death domain , and TNF receptor associated protein with death domain but not NIK or TRAF-6 proteins . Positive_regulation MMP9 TNF 17897957 1824030 We conclude that TAK1 mediated pathways are involved in *induced* [MMP-9] production in skeletal muscle cells . Positive_regulation MMP9 TNF 17942934 1814225 The *induction* of various antiapoptotic gene products ( [MMP-9] , cyclin D1 , COX-2 , IAP1 , IAP2 , Bcl-2 , cFLIP , and XIAP ) by was also abolished in NQO2-/- cells . Positive_regulation MMP9 TNF 17964422 1820283 Besides , pretreatment with carvedilol or probucol but not propranolol , a beta-blocker , or prazocin , an alpha-blocker , inhibited *stimulated* expressions and activities of MMP-2 and [MMP-9] in human aortic smooth muscle cells . Positive_regulation MMP9 TNF 17988825 1931712 *induced* the [MMP-9] expression in HepG2 cells . Positive_regulation MMP9 TNF 17988825 1931715 Our results showed that resveratrol inhibited *mediated* [MMP-9] expression and invasion of human hepatocellular carcinoma cells . Positive_regulation MMP9 TNF 18060869 1846780 *stimulated* [MMP-9] expression and Erk1/2 activation were both significantly inhibited by LOX-PP. Immunohistochemistry studies carried out with affinity purified anti-LOX-PP antibody showed that LOX-PP epitopes were expressed at elevated levels in vascular lesions of injured arteries . Positive_regulation MMP9 TNF 18177935 1894966 Concurrently , both the irreversible inhibitor of ODC , alpha-difluoromethylornithine , and could not *recover* [MMP-9] activation following NF-kappaB inhibitor treatment in parental cells . Positive_regulation MMP9 TNF 18222174 1871078 Eicosapentaenoic acid inhibits *induced* [matrix metalloproteinase-9] expression in human keratinocytes , HaCaT cells . Positive_regulation MMP9 TNF 18222174 1871081 In this report , we investigated whether EPA inhibits the expression of *induced* [matrix metalloproteinases (MMP)-9] in human immortalized keratinocytes ( HaCaT ) . Positive_regulation MMP9 TNF 18222174 1871083 *induced* [MMP-9] expression by NF-kappaB dependent pathway . Positive_regulation MMP9 TNF 18222174 1871085 Pretreatment of EPA inhibited *induced* [MMP-9] expression and p65 phosphorylation . Positive_regulation MMP9 TNF 18222174 1871092 Taken together , we demonstrate that EPA inhibits *induced* [MMP-9] expression through inhibition of p38 and Akt activation . Positive_regulation MMP9 TNF 18252806 1895831 TNF-alpha *induces* the expression of transcripts for inflammatory mediators interleukin (IL)-6 , IL-8 , regulated on activation normal T cell expressed and secreted , , granulocyte macrophage-colony stimulating factor ( GM-CSF ) , and monocyte chemoattractant protein (MCP)-1 and also invasion mediators matrix metalloproteinase (MMP)-7 , [MMP-9] , and intracellular adhesion molecule-1 . Positive_regulation MMP9 TNF 18276934 1911670 Similarly , quantitative RT-PCR found that and IL1B *enhanced* [MMP9] , but not MMP2 , mRNA levels . Positive_regulation MMP9 TNF 18288389 1872687 M1 was effective in suppressing the induced *activation* of NF-kappaB , expression of [matrix metalloprotease-9 (MMP-9)] , migration and invasion . Positive_regulation MMP9 TNF 18292581 1873019 [MMP-9] release was *dependent* on released from IgE activated BMCMC and on adhesive interactions between BMCMC and fibroblasts . Positive_regulation MMP9 TNF 18311803 1885967 [MMP-9] was *up-regulated* by and produced primarily by vascular smooth muscle cells . Positive_regulation MMP9 TNF 18336852 1912233 *induces* [MMP-9] expression via p42/p44 MAPK , JNK , and nuclear factor-kappaB in A549 cells . Positive_regulation MMP9 TNF 18336852 1912234 However , the mechanisms underlying [MMP-9] expression *induced* by in human A549 cells remain unclear . Positive_regulation MMP9 TNF 18336852 1912248 Furthermore , the involvement of NF-kappaB in *induced* [MMP-9] production was consistent with that TNF-alpha stimulated degradation of IkappaB-alpha and translocation of NF-kappaB into the nucleus which were blocked by helenalin , but not by U0126 and SP600125 , revealed by immunofluorescence staining . Positive_regulation MMP9 TNF 18336852 1912256 [MMP-9] promoter activity was *enhanced* by in A549 cells transfected with wild-type MMP-9-Luc , which was inhibited by helenalin , U0126 , or SP600125 . Positive_regulation MMP9 TNF 18336852 1912257 In contrast , *stimulated* [MMP-9] luciferase activity was totally lost in cells transfected with mutant-NF-kappaB MMP-9-luc . Positive_regulation MMP9 TNF 18336852 1912258 Moreover , pretreatment with actinomycin D and cycloheximide attenuated *induced* [MMP-9] expression . Positive_regulation MMP9 TNF 18336852 1912259 These results suggest that in A549 cells , phosphorylation of p42/p44 MAPK , JNK , and transactivation of NF-kappaB are essential for *induced* [MMP-9] gene expression . Positive_regulation MMP9 TNF 18357389 1887716 *stimulated* the secretion of [MMP-9] in HT1376 cells , as shown by zymography and immunoblot analysis . Positive_regulation MMP9 TNF 18357389 1887717 At the level of transcription , also *stimulated* 5'-flanking promoter activity of [MMP-9] . Positive_regulation MMP9 TNF 18357389 1887721 The ERK1/2 inhibitor , U0126 and the p38 MAP kinase inhibitor , SB203580 , significantly down-regulated *induced* [MMP-9] expression and promoter activity . Positive_regulation MMP9 TNF 18357389 1887728 In conclusion , the findings of the present study indicate that *induces* [MMP-9] expression in HT1376 cells by activating transcription factors , which are involved in the ERK1/2- and p38 MAP kinase mediated control of MMP-9 regulation , namely , NF-kappaB , AP-1 and Sp-1 . Positive_regulation MMP9 TNF 18435913 1908195 In the present study , *increased* cell motility and [MMP-9] and TNFalpha expression at the transcriptional level . Positive_regulation MMP9 TNF 18449943 1932937 Gelatin zymography confirmed that LPS and *induced* strong expression of [MMP-9] in microglia but not astrocytes . Positive_regulation MMP9 TNF 18449943 1932938 Using this system , we have shown that astrocytes and microglia express distinct sets of MMP genes and that microglia , not astrocytes , are the major source of [MMP-9] in *response* to LPS or . Positive_regulation MMP9 TNF 18496150 1939350 We discovered that the [MMP-9] promoter was significantly *stimulated* by phorbol myristate acetate and on luciferase reporter gene assays . Positive_regulation MMP9 TNF 18496150 1939351 Functional activation of the [MMP-9] protein was *stimulated* by and PMA on a fluorescent enzyme linked immunosorbent serologic assay . Positive_regulation MMP9 TNF 18541003 1971987 In addition , the pro-inflammatory , produced in response to collagen I , *increased* [MMP-9] production . Positive_regulation MMP9 TNF 18606251 1947250 In the co-culture assay between Jurkat cells and ECV-304 cells , the MMP-9 secretion from Jurkat cells was inhibited after astilbin-treatment , while the exogenous *increased* the [MMP-9] secretion in a dose dependent manner . Positive_regulation MMP9 TNF 18710428 2028193 Upregulation of [matrix metalloproteinase-9 (MMP-9)] *induced* by is reportedly involved in a variety of non-neoplastic and neoplastic diseases . Positive_regulation MMP9 TNF 18710428 2028194 In this study , we examined which signalling pathways are involved in *induced* [MMP-9] upregulation in cholangiocarcinoma ( CC ) . Positive_regulation MMP9 TNF 18710428 2028195 In an ex vivo study using HuCCT-1 and CCKS-1 cells , treatment *induced* [MMP-9] production and activation via interaction with TNF receptor-1 (TNF-R1) but not with TNF receptor-2 (TNF-R2) , shown by zymography , and increased MMP-9 promoter activity ( luciferase assay ) . Positive_regulation MMP9 TNF 18723334 1984969 In contrast , fibroblasts in areas of parenchymal destruction of emphysema/UIP expressed MMP-2 , [MMP-9] , MMP-7 and MT1-MMP at variable but significantly higher levels when compared to emphysema subjects , in the *presence* of similar levels of TIMP-1 , TIMP-2 and . Positive_regulation MMP9 TNF 18799129 2012280 *induced* [matrix metalloproteinase-9 (MMP-9)] expression was also decreased in aged rGF in comparison with young rGF . Positive_regulation MMP9 TNF 18801463 1981181 Signaling pathway for *induced* [MMP-9] expression : mediation through p38 MAP kinase , and inhibition by anti-cancer molecule magnolol in human urinary bladder cancer 5637 cells . Positive_regulation MMP9 TNF 18824875 1981584 Treatment of cells with the specific iNOS inhibitor L-NIL potentiated the increase in [MMP-9] production *induced* by , but prevented the suppression of TIMP-1 production observed following cytokine treatment . Positive_regulation MMP9 TNF 18824875 1981585 The NO donor , sodium nitroprusside , also stimulated a substantial increase in NO production in HMCL cells , which was associated with a reduction in basal and *stimulated* [MMP-9] and a potentiation of the cytokine induced decrease in TIMP-1 . Positive_regulation MMP9 TNF 19026560 2001522 suppressed collagen type II and aggrecan , but *increased* [MMP] and cytokine expression in chondrocytes compared to the non stimulated controls . Positive_regulation MMP9 TNF 19052522 1999721 Berberine suppresses *induced* [MMP-9] and cell invasion through inhibition of AP-1 activity in MDA-MB-231 human breast cancer cells . Positive_regulation MMP9 TNF 19052522 1999722 The basal level of MMP-9 activity and expression was dose-dependently increased by TNF-alpha , while *induced* [MMP-9] gelatinase activity and expression was decreased by BBR . Positive_regulation MMP9 TNF 19052522 1999723 To investigate regulatory mechanism of *induced* [MMP-9] expression , we pretreated cells with UO126 ( MEK inhibitor ) , SB203580 ( p38 inhibitor ) and SP600125 ( JNK inhibitor ) , respectively . Positive_regulation MMP9 TNF 19052522 1999724 Interestingly , *induced* [MMP-9] activity and expression was decreased by UO126 and SB203580 , but not by SP600125 . Positive_regulation MMP9 TNF 19052522 1999727 Taken together , we suggest that *induced* [MMP-9] expression and cell invasion are decreased by BBR through the suppression of AP-1 DNA binding activity in MDA-MB-231 human breast cancer cells . Positive_regulation MMP9 TNF 19218340 2039516 The interaction *induced* [MMP-9] production and activation , as well as COX-2 overexpression and PGE2 production , and increased the migration of CC cells . Positive_regulation MMP9 TNF 19298660 2056096 *induced* expression of [matrix metalloproteinase-9] through p21 activated kinase-1 . Positive_regulation MMP9 TNF 19298660 2056103 Ectopic expression of PAK1 variants , but not p38 MAP kinase , impaired the *induced* [MMP-9] expression , while other MMPs such as MMP-2 , -3 and -14 were not affected . Positive_regulation MMP9 TNF 19306950 2080123 [Matrix metalloproteinase-9 (MMP-9)] expression and migration were also increased in *response* to in SHR derived cells . Positive_regulation MMP9 TNF 19401153 2070353 Activation of phosphatidylinositol 3-kinase is required for *induced* upregulation of [matrix metalloproteinase-9] : its direct inhibition by quercetin . Positive_regulation MMP9 TNF 19401153 2070356 The present study investigated the possible inhibitory effects of red wine polyphenols on *induced* upregulation of [MMP-9] and on the migratory phenotype of JB6 P+ mouse epidermal ( JB6 P+ ) cells . Positive_regulation MMP9 TNF 19401153 2070357 Red wine extract ( RWE ) and quercetin , which is a major flavonoid present in red wine , inhibited significantly the induced *upregulation* of [MMP-9] and cell migration , whereas resveratrol did not have significant inhibitory effects . Positive_regulation MMP9 TNF 19401153 2070358 Using chemical inhibitors , it was confirmed that the PI3K dependent Akt pathway was involved in *induced* [MMP-9] upregulation and migration in JB6 P+ cells . Positive_regulation MMP9 TNF 19401153 2070359 Collectively , these results indicate that *induced* [MMP-9] upregulation and the migratory phenotype are associated with the PI3K/Akt pathway , and that these effects are inhibited strongly by RWE and quercetin . Positive_regulation MMP9 TNF 19435506 2106985 does not *induce* [MMP] expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation MMP9 TNF 19565485 2104302 Using a murine model of KD , we established and validated several in vitro techniques to reflect 3 key steps involved in disease pathogenesis , as follows : thymidine incorporation to evaluate T cell activation , enzyme linked immunosorbent assay to measure tumor necrosis factor alpha (TNFalpha) production , and real-time polymerase chain reaction to examine *mediated* expression of [matrix metalloproteinase 9 (MMP-9)] . Positive_regulation MMP9 TNF 19672675 2132844 Gelatin zymography results showed that pretreatment with EGE to human umbilical vein endothelial cells ( HUVEC ) decreased *induced* increase of [matrix metalloproteinase (MMP)-2/-9] activities in the range of 1-50 microg/ml. Real-time qRT-PCR results also revealed that TNF-alpha induced MMP-2/-9 mRNA expression levels were attenuated by pretreatment with EGE . Positive_regulation MMP9 TNF 19774448 2216864 Fucoidan increases *induced* [MMP-9] secretion in monocytic cell line U937 . Positive_regulation MMP9 TNF 19774448 2216865 Fucoidan can increase the *induced* [MMP-9] secretion from U937 ( P < 0.05 ) , but no significant difference was observed in MMP-9 mRNA . Positive_regulation MMP9 TNF 19810018 2168616 Naringin inhibited *induced* expression of [MMP-9] , under 10-25 microM concentration conditions in vascular smooth muscle cells ( VSMC ) . Positive_regulation MMP9 TNF 19885606 2161188 In addition , *induced* [matrix metalloproteinase-9 (MMP-9)] expression was inhibited by EEGS treatment via decreased transcriptional activity of both activator protein-1 (AP-1) and nuclear factor-kappaB . Positive_regulation MMP9 TNF 19924065 2167044 Silibinin suppresses *induced* [MMP-9] expression in gastric cancer cells through inhibition of the MAPK pathway . Positive_regulation MMP9 TNF 19924065 2167045 In this study we determined the effect of silibinin on *induced* [MMP-9] expression in gastric cancer cell lines . Positive_regulation MMP9 TNF 19924065 2167046 On the other hand , *induced* [MMP-9] expression was dose-dependently suppressed by silibinin . Positive_regulation MMP9 TNF 19924065 2167047 To verify the regulatory mechanism of silibinin on *induced* [MMP-9] expression , the gastric cancer cell lines were pretreated with silibinin prior to TNF-alpha . Positive_regulation MMP9 TNF 19924065 2167069 Taken together , we suggest that silibinin down-regulates *induced* [MMP-9] expression through inhibition of the MEK/ERK pathway in gastric cancer cells . Positive_regulation MMP9 TNF 20007453 2210600 We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since *induced* superoxide production , [MMP] expression , and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma . Positive_regulation MMP9 TNF 20010305 2191296 Mycobacterium leprae and *induced* upregulation of MMP-2 and [MMP-9] and increased secretion of these enzymes in cultured ST88-14 cells . Positive_regulation MMP9 TNF 20020446 2191709 *Upregulation* of [MMP-9] production by in keratinocytes and its attenuation by vitamin D . Positive_regulation MMP9 TNF 20020446 2191712 ( TNFalpha ) , a key mediator of cutaneous inflammation , is a powerful *inducer* of [MMP-9] . Positive_regulation MMP9 TNF 20020446 2191752 Employing specific inhibitors we established that the *induction* of [MMP-9] by was dependent on the activity of the epidermal growth factor receptor , c-Jun-N-terminal kinase (JNK) , NFkappaB and extracellular signal regulated kinase-1/2 . Positive_regulation MMP9 TNF 20093109 2226138 Our results show that *induced* expression of [MMP-9] at both mRNA and protein levels was completely blocked by EK5 in a concentration dependent ( 1-20microM ) manner . Positive_regulation MMP9 TNF 20332214 2238118 This study shows that Egr-1 directly binds to the MMP-9 promoter and plays an essential role for *induction* of [MMP-9] transcription . Positive_regulation MMP9 TNF 20332214 2238119 Furthermore , Egr-1 together with NF-kappaB can synergistically activate both basal and *induced* [MMP-9] promoter activities in the presence of p300 . Positive_regulation MMP9 TNF 20332214 2238133 The requirement for Egr-1 in MMP-9 expression is further supported by the fact that HeLa cells expressing Egr-1 siRNA and Egr-1-null mouse embryonic fibroblasts were refractory to *induced* [MMP-9] expression . Positive_regulation MMP9 TNF 20332214 2238134 This report establishes that Egr-1 is essential for [MMP-9] transcription in *response* to within the tumor microenvironment . Positive_regulation MMP9 TNF 20333651 2266129 *induces* [matrix metalloproteinase-9] expression in A549 cells : role of TNFR1/TRAF2/PKCalpha dependent signaling pathways . Positive_regulation MMP9 TNF 20333651 2266130 However , the mechanisms underlying *induced* [MMP-9] expression in human A549 cells remain unclear . Positive_regulation MMP9 TNF 20333651 2266131 Here , we report that *induced* [MMP-9] gene expression was mediated through the TNFR1/TRAF2/PKCalpha dependent signaling pathways in A549 cells , determined by zymographic , RT-PCR , and Western blotting analyses . Positive_regulation MMP9 TNF 20333651 2266135 In addition , *induced* [MMP-9] expression was also reduced by pretreatment with the inhibitor of PKCalpha ( Gö6983 ) , c-Src ( PP1 ) , EGFR ( AG1478 ) , or PI3K ( LY294002 ) or transfection with siRNAs of PKCalpha , Src , EGFR , Akt , p65 , p300 , and c-Jun . Positive_regulation MMP9 TNF 20333651 2266179 Taken together , these data suggest that in A549 cells , *induces* [MMP-9] expression via the TNFR1/TRAF2/PKCalpha dependent JNK1/2/c-Jun and c-Src/EGFR/PI3K/Akt pathways . Positive_regulation MMP9 TNF 20403361 2267439 While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha , however , [matrix metalloproteinase (MMP)] *activation* of may also be contributory . Positive_regulation MMP9 TNF 20463356 2301056 *stimulates* [matrix metalloproteinase 9] secretion from cultured human chorionic trophoblast cells through TNF receptor 1 signaling to IKBKB-NFKB and MAPK1/3 pathway . Positive_regulation MMP9 TNF 20463356 2301057 In this study , we examine which signaling pathways are involved in *induced* [matrix metalloproteinase 9 (MMP9)] secretion in human chorionic trophoblast ( CT ) cells . Positive_regulation MMP9 TNF 20534943 2295634 Interleukin (IL)-1beta , IL-6 , and *stimulated* [MMP-9] expression , whereas interferon (IFN)-gamma suppressed it . Positive_regulation MMP9 TNF 20561612 2345353 Pretreatment of endometriotic stromal cells with PDTC attenuated *induced* expressions of CD44s , [matrix metalloproteinase-9] , and vascular endothelial growth factor whereas reversed tumor necrosis factor-a reduced expressions of tissue inhibitor of metalloproteinase-1 revealed by reverse transcriptase polymerase chain reaction and Western blot analysis , suggesting that PDTC may represent a novel therapeutic strategy for treatment of endometriosis . Positive_regulation MMP9 TNF 20564512 2345407 Cordycepin suppresses *induced* invasion , migration and [matrix metalloproteinase-9] expression in human bladder cancer cells . Positive_regulation MMP9 TNF 20564512 2345408 Furthermore , the *induced* [MMP-9] expression was suppressed by cordycepin , but MMP-2 expression was not . Positive_regulation MMP9 TNF 20617373 2418886 Expression of interleukin (IL)-6 , IL-8 , and were substantially increased and *involved* in macrophage induced VEGF and [MMP-9] mRNA expression in MCF-7 cells . Positive_regulation MMP9 TNF 20618688 2286566 Increase of in the blood *induces* early activation of [matrix metalloproteinase-9] in the brain . Positive_regulation MMP9 TNF 20618688 2286567 These findings suggest that an increase in blood *promotes* activation of [MMP-9] in the brain , and may also induce an increase in permeability of the BBB . Positive_regulation MMP9 TNF 20642847 2297572 Pg-FET and its constituents inhibited the secretion of [MMP-9] *induced* by haemozoin or . Positive_regulation MMP9 TNF 20943041 2332959 Both and TGF-beta were found to divergently *enhance* [MMP-9] and MMP-2 secretion respectively , with stimulation indexes of two and five respectively . Positive_regulation MMP9 TNF 21028821 2348933 [MMP-9] activity is *promoted* by the pro-inflammatory cytokine . Positive_regulation MMP9 TNF 21028821 2348934 GMI reduced *induced* [MMP-9] activities on gelatin zymography assay through inhibition of MMP-9 transcriptional activity . Positive_regulation MMP9 TNF 21067565 2354687 In U251 and U373 cells expression of [MMP-9] and MMP-19 was *stimulated* by . Positive_regulation MMP9 TNF 21072492 2366053 Furthermore , *induced* [matrix metalloproteinase-9 (MMP-9)] expression and promoter activity were also decreased in GM3 synthase gene transfectants . Positive_regulation MMP9 TNF 21361911 2411457 Similarly , *induced* [MMP-9] production was reduced in a dose dependent manner in response to atorvastatin . Positive_regulation MMP9 TNF 21453692 2432611 In this study , we found that AA showed concentration dependent inhibition of *induced* [MMP-9] activation with an IC ( 50 ) value of 6.4±0.5µM in human monocytic THP-1 cells . Positive_regulation MMP9 TNF 21453692 2432612 From these results , we concluded that AA , a natural compound , inhibits *induced* [MMP-9] in human monocytic cells possibly through the NF-?B signal pathway . Positive_regulation MMP9 TNF 21468574 2413162 In addition , both zymographic and immunoblot experiments showed that esculetin suppressed the *induced* expression of [MMP-9] in VSMC in a dose dependent manner . Positive_regulation MMP9 TNF 21473134 2413410 may *induce* the expression of [MMP-9] and promote the migration of eosinophil granulocyte . Positive_regulation MMP9 TNF 21502320 2434838 The interferon-gamma induced GTPase , mGBP-2 , inhibits *induction* of [matrix metalloproteinase-9 (MMP-9)] by inhibiting NF-kappaB and Rac protein . Positive_regulation MMP9 TNF 21502320 2434841 We found that IFN-? treatment or forced expression of the IFN induced GTPase , mGBP-2 , inhibit *induced* [MMP-9] expression in NIH 3T3 fibroblasts , by inhibiting MMP-9 transcription . Positive_regulation MMP9 TNF 21502320 2434850 The NF-?B transcription factor is required for full *induction* of [MMP-9] by . Positive_regulation MMP9 TNF 21514443 2418736 Lack of *induced* [MMP-9] production and abnormal E-cadherin redistribution associated with compromised fusion in MCP-1-null macrophages . Positive_regulation MMP9 TNF 21514443 2418737 Exogenous *caused* an increase in the production of [MMP-9] and rescued the fusion defect . Positive_regulation MMP9 TNF 21523796 2444477 In addition , [matrix metalloproteinase 9 (MMP-9)] expression was *dependent* on binding to TNFR1 in primary mouse HSCs . Positive_regulation MMP9 TNF 21628889 2437000 3-Deoxysappanchalcone inhibits *induced* [matrix metalloproteinase-9] expression in human keratinocytes through activated protein-1 inhibition and nuclear factor-kappa B DNA binding activity . Positive_regulation MMP9 TNF 21628889 2437001 , which is a primary cytokine responsible for inflammatory responses in skin , *induces* the synthesis of [matrix metalloproteinase-9 (MMP-9)] , which causes skin aging . Positive_regulation MMP9 TNF 21760774 2456249 The *upregulation* of [MMP-9] by or LPS was inhibited by COX-2 inhibitor NS398 . Positive_regulation MMP9 TNF 21777517 2456903 Suppression of *induced* [MMP-9] expression by a cell-permeable superoxide dismutase in keratinocytes . Positive_regulation MMP9 TNF 21777517 2456904 In this study , we examined the effect of a cell-permeable superoxide dismutase ( Tat-SOD ) on *induced* [MMP-9] expression in human keratinocyte cells ( HaCaT ) . Positive_regulation MMP9 TNF 21777517 2456912 In addition , Tat-SOD suppressed *induced* gelatinolytic activity of [MMP-9] . Positive_regulation MMP9 TNF 21777517 2456917 Taken together , our results indicate that Tat-SOD can suppress *induced* [MMP-9] expression via ROS-NF-?B dependent mechanisms in keratinocytes , and therefore can be used as an immunomodulatory agent against inflammatory skin diseases related to oxidative stress . Positive_regulation MMP9 TNF 21783814 1847969 In this study , we have more extensively investigated the inhibitory effect of UR on [MMP-9] activity and *induced* human aortic smooth muscle cells ( HASMC ) migration . Positive_regulation MMP9 TNF 21792602 2554469 IL-1ß or *increased* expression of [MMP-9] and MMP-2 in rheumatoid synoviocytes ; Positive_regulation MMP9 TNF 21792602 2554475 While pretreatment with PD098059 had no marked inhibitory effect on [MMP-9] expression *induced* by or IL-1ß , SP600125 decreased significantly the MMP-9 expression induced by TNF-a or IL-1ß . Positive_regulation MMP9 TNF 21809585 2462568 The mechanism may include reducing , IL-1beta content and *inhibiting* overexpression of [matrix metalloproteinase-9] in lung tissues . Positive_regulation MMP9 TNF 21820422 2490443 Triptolide also abrogated *induced* expression of cell survival proteins ( XIAP , Bcl-x ( L ) , Bcl-2 , survivin , cIAP-1 and cIAP-2 ) , cell proliferative proteins ( cyclin D1 , c-myc and cyclooxygenase-2 ) , and metastasis proteins ( ICAM-1 and [MMP-9] ) . Positive_regulation MMP9 TNF 21845471 2574361 Triple inhibitory activity of Cliona celata against *induced* [matrix metalloproteinase-9] production via downregulated NF-?B and AP-1 , enzyme activity , and migration potential . Positive_regulation MMP9 TNF 21856755 2473283 While overexpression of NF-?B p65 alone could induce E-cadherin loss in RCC , EMT phenotypes and [MMP9] expressions *induced* by were not reversed by the inhibitors of NF-?B activation . Positive_regulation MMP9 TNF 21899405 2478218 Dimethyl sulfoxide attenuates *induced* production of [MMP-9] in human keratinocytes . Positive_regulation MMP9 TNF 21899405 2478219 The aim of this study was to investigate whether *induced* [MMP-9] levels and MMP-9 mRNA expression from human keratinocytes ( HaCaT ) might be attenuated by DMSO . Positive_regulation MMP9 TNF 22060290 2504137 RT-PCR and immunoblot analyses show that Cholestin extract significantly attenuates *induced* mRNA and protein expressions of MMP-2 and [MMP-9] . Positive_regulation MMP9 TNF 22060290 2504139 Cholestin reduces *stimulated* MMP-2 and [MMP-9] expression as well as downregulating NF-?B activation and intracellular ROS formation in HASMCs , supporting the notion that the natural compound Cholestin may have potential application in clinical atherosclerosis disease . Positive_regulation MMP9 TNF 22112961 2574778 In vitro , pre-incubation with JWH-133 reduced *mediated* release of [MMP-9] . Positive_regulation MMP9 TNF 22167104 2617269 MMP-2 expression seemed to be increased by TNF-a and IL-1ß while [MMP-9] was *enhanced* by and IL-6 . Positive_regulation MMP9 TNF 22321809 2576054 ( designated as TNF-a under previous nomenclature ) is the preeminent *activator* of [MMP-9] generation from a variety of cells including eosinophils . Positive_regulation MMP9 TNF 22321809 2576055 Thus , we sought to determine if *induced* synthesis of [MMP-9] would be enhanced by the presence of Th1 , Th2 , or the eosinophil associated common beta chain ( ßc ) cytokines . Positive_regulation MMP9 TNF 22321809 2576057 Remarkable synergistic synthesis of [MMP-9] ( ng/ml levels ) occurred in *response* to plus IL-3 , GM-CSF or IL-5 , in the order of IL-3 > GM-CSF > IL-5 . Positive_regulation MMP9 TNF 22336124 2520795 To investigate the effect of focal adhesional kinase ( FAK ) on *induced* [MMP-2 and -9] activities in cornea epithelium . Positive_regulation MMP9 TNF 22353423 2586877 In vitro , results based on cultured DRG neurons showed that siRNA mediated inhibition of NOV enhanced IL-1ß- and TNF-a induced MMP-2 , MMP-9 and CCL2 expression whereas NOV addition inhibited *induced* [MMP-9] expression through ß1 integrin engagement . Positive_regulation MMP9 TNF 22392094 2587511 Further , we found that *induced* [MMP-9] secretion in vitro was reduced by pretreatment of RPE cells with BMP4 . Positive_regulation MMP9 TNF 22392094 2587520 The inhibition of MMP-9 was Smad dependent because BMP4 failed to repress *induced* [MMP-9] expression when Smad1 ,5 was silenced by siRNA . Positive_regulation MMP9 TNF 22419430 2572798 Gleditsia sinensis thorn extract inhibits proliferation and *induced* [MMP-9] expression in vascular smooth muscle cells . Positive_regulation MMP9 TNF 22419430 2572799 Moreover , EEGS inhibited [matrix metalloproteinase-9 (MMP-9)] expression *induced* by in VSMC . Positive_regulation MMP9 TNF 22427508 2594293 strongly *induced* CaMKII oxidation and autophosphorylation as well as [MMP9] activity , mRNA , and protein levels in WT , but not in CaMKIId ( -/- ) VSMC . Positive_regulation MMP9 TNF 22427508 2594295 Surprisingly , strongly *induced* [MMP9] promoter activity in WT and CaMKIId ( -/- ) VSMC . Positive_regulation MMP9 TNF 22491155 2606934 Low concentrations of minocycline could not reduce *induced* [MMP-9] release from endothelial cells . Positive_regulation MMP9 TNF 22572236 2603575 Also , cultures of bovine peripheral neutrophils were conducted to examine the mode of short-term [MMP-9] secretion in *response* to stimulation and the blocking effects of TNF-a antibody and inhibitors of MAPK pathways . Positive_regulation MMP9 TNF 22572236 2603577 In vitro studies indicate linear *increase* of short-term [MMP-9] release in response to stimulation in dosages between 0.1 and 10 ng/ml . Positive_regulation MMP9 TNF 22658256 2620369 META060 attenuates *activated* inflammation , endothelial-monocyte interactions , and [matrix metalloproteinase-9] expression , and inhibits NF-?B and AP-1 in THP-1 monocytes . Positive_regulation MMP9 TNF 22684781 2633456 Moreover , OPN and [MMP-9] were *enhanced* by and down-regulated by anti-TNF-a treatment in healthy PBMC . Positive_regulation MMP9 TNF 22684781 2633457 These findings may suggest that OPN and [MMP-9] may be *regulated* by , indicating a possible role in the pathogenesis of psoriasis . Positive_regulation MMP9 TNF 22710949 2687010 *stimulates* MMP-2 and [MMP-9] activities in human corneal epithelial cells via the activation of FAK/ERK signaling . Positive_regulation MMP9 TNF 22710949 2687015 Furthermore , *stimulated* MMP-2 and [MMP-9] activities in a dose dependent manner , but either knockdown of focal adhesion kinase ( FAK ) by short interference RNA or inhibition of extracellular regulated protein kinase ( ERK ) by chemical inhibitor could block TNF-a stimulated MMP-2 and MMP-9 activities in vitro . Positive_regulation MMP9 TNF 22710949 2687018 Taken together , our results provide in vivo evidence that the TNF-a level is positively correlated with MMP-2 and MMP-9 levels in a HSK model and in vitro evidence that *stimulates* MMP-2 and [MMP-9] activities via the activation of FAK/ERK signaling in HCE cells . Positive_regulation MMP9 TNF 22820188 2646141 Suppression Akt/mTOR complex 1(mTORC1) activation by LY 294002 and rapamycin inhibited *mediated* [MMP-9] expression . Positive_regulation MMP9 TNF 22926441 2683362 Melttin significantly suppressed MMP-9 and MMP-2 secretion , as well as *induced* [MMP-9] expression in the HASMCs . Positive_regulation MMP9 TNF 22926441 2683363 In addition , we found that the inhibitory effects of melittin on *induced* [MMP-9] protein expression are associated with the inhibition of MMP-9 transcription levels . Positive_regulation MMP9 TNF 22926441 2683364 Mechanistically , Melittin suppressed *induced* [MMP-9] activity by inhibiting the phosphorylation of p38 and ERK1/2 , but did not affect the phosphorylation of JNK and Akt . Positive_regulation MMP9 TNF 23300643 2712405 Fibroblasts from intestinal muscle expressed Ra1 , phosphorylated STAT6 in response to IL-13 , and subsequently down-regulated MMP-2 and *induced* MMP-1 and [MMP-9] synthesis . Positive_regulation MMP9 TNF 23353699 2754221 c-Src dependent MAPKs/AP-1 activation is involved in *induced* [matrix metalloproteinase-9] expression in rat heart derived H9c2 cells . Positive_regulation MMP9 TNF 23353699 2754226 However , the detailed mechanisms of *induced* [MMP-9] expression are largely unclear in the heart cells . Positive_regulation MMP9 TNF 23353699 2754228 Here , we demonstrated that in rat embryonic-heart derived H9c2 cells , could *induce* [MMP-9] mRNA expression associated with an increase in the secretion of MMP-9 , determined by real-time PCR , zymography , and promoter activity assays . Positive_regulation MMP9 TNF 23353699 2754250 These results suggested that *induced* [MMP-9] expression is mediated through a c-Src/EGFR , PDGFR/PI3K/Akt/MAPKs/AP-1 cascade in H9c2 cells . Positive_regulation MMP9 TNF 23417988 2843318 SUMO-2/3 was knocked down using small interfering RNA in SFs , and *induced* [MMP] production was determined by ELISA . Positive_regulation MMP9 TNF 23417988 2843351 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by TNF-a and selectively control *mediated* [MMP] expression via the NF-?B pathway . Positive_regulation MMP9 TNF 23427281 2887211 The *induces* eNOS and [MMP-9] expression and PKB activation . Positive_regulation MMP9 TNF 23435195 2771333 In this study , we demonstrated that rLj-RGD3 suppressed *induced* [MMP-9] secretion in 786-0 cells ( human renal carcinoma cells ) . Positive_regulation MMP9 TNF 23435195 2771334 To investigate the regulatory effect of rLj-RGD3 on *induced* [MMP-9] secretion , we pre treated cells with rLj-RGD3 . Positive_regulation MMP9 TNF 23435195 2771335 However , low concentrations of rLj-RGD3 decreased *induced* [MMP-9] secretion . Positive_regulation MMP9 TNF 23587438 2778576 Brucella abortus induces *dependent* astroglial [MMP-9] secretion through mitogen activated protein kinases . Positive_regulation MMP9 TNF 23603294 2795172 The expression of MMP-1 , MMP-3 , and [MMP-9] increased in the *presence* of , and the addition of infliximab reversed the increase . Positive_regulation MMP9 TNF 23603294 2795194 Furthermore , infliximab effectively attenuated the *induced* increases in [MMP] expression in cells that make up the BAB . Positive_regulation MMP9 TNF 23774252 2843915 NADPH oxidase/ROS dependent PYK2 activation is involved in *induced* [matrix metalloproteinase-9] expression in rat heart derived H9c2 cells . Positive_regulation MMP9 TNF 23774252 2843934 However , the detailed mechanisms of *induced* [MMP-9] expression in rat embryonic-heart derived H9c2 cells are largely not defined . Positive_regulation MMP9 TNF 23774252 2843952 Thus , in H9c2 cells , we are the first to show that *induced* [MMP-9] expression is mediated through a TNFR1/NADPH oxidase/ROS/PYK2/MAPKs/NF-?B cascade . Positive_regulation MMP9 TNF 23774252 2843957 Understanding the regulation of [MMP-9] expression and NADPH oxidase *activation* by on H9c2 cells may provide potential therapeutic targets of chronic heart failure . Positive_regulation MMP9 TNF 23812412 2828831 Fir honeydew honey flavonoids inhibit *induced* [MMP-9] expression in human keratinocytes : a new action of honey in wound healing . Positive_regulation MMP9 TNF 23812412 2828832 The aim of this study was to investigate the effect of fir honeydew honey on *induced* [MMP-9] expression and secretion from human keratinocytes ( HaCaT ) and to identify the honey component ( s ) responsible for a discovered effect . Positive_regulation MMP9 TNF 23812412 2828833 We found that HAE inhibited *induced* production of [MMP-9] in keratinocytes in a dose dependent manner at both the mRNA and protein levels . Positive_regulation MMP9 TNF 23861949 2817412 Celastrol inhibits lipopolysaccharide stimulated rheumatoid fibroblast-like synoviocyte invasion through suppression of *mediated* [matrix metalloproteinase-9] expression . Positive_regulation MMP9 TNF 23861949 2817414 In conclusion , celastrol might inhibit FLS migration and invasion induced by LPS by suppressing *mediated* [MMP-9] expression , providing a theoretical foundation for the clinical treatment of RA with celastrol . Positive_regulation MMP9 TNF 24085323 2857996 In chondrosarcoma cells , had a stimulatory effect on MMP-9 and insignificant effect on MMP-2 and interleukin (IL)-1ß *stimulated* [MMP-9] and MMP-2 . Positive_regulation MMP9 TNF 24085323 2858000 In fibrosarcoma and liposarcoma cells , *had* a profound stimulatory effect on [MMP-9] , but no effect on MMP-2 and in synovial sarcoma an inhibitory effect on MMP-2 and no effect on MMP-9 . Positive_regulation MMP9 TNF 24190483 2885842 , interleukin-1ß and LPS *enhanced* osteosarcoma U2OS [MMP-9] secretion but had no effect on MMP-2 secretion . Positive_regulation MMP9 TNF 24200302 2864457 Our previous study suggested that *induced* activation of [matrix metalloproteinase-9 (MMP-9)] resulted in the destruction of acinar tissue in the salivary glands of patients with Sjögren 's syndrome ( SS ) via disruption of the acinar cell-basement membrane . Positive_regulation MMP9 TNF 24200302 2864458 In this study , we demonstrate the suppressive effect of anti-TNF agents on *induced* [MMP-9] production in NS-AV-AC , an immortalized human salivary gland acinar cell line . Positive_regulation MMP9 TNF 24200302 2864459 *induced* the production of [MMP-9] in NS-SV-AC cells . Positive_regulation MMP9 TNF 24211395 2891822 Furthermore , AS suppressed *induced* activity and expression of [matrix metalloproteinase-9 (MMP-9)] , and cell-surface expression of intercellular adhesion molecule-1 ( ICAM-1 ) , which was associated with abridged adhesion of U937 leukocytes to endothelial cells . Positive_regulation MMP9 TNF 24279124 2876951 In cultured vascular smooth muscle cells ( SMCs ) , significantly *activated* both [Mmp9] and Timp1 expression , and they were blocked by Jun kinase inhibitor ( SP600125 ) in a dose dependent manner . Positive_regulation MMP9 TNF 24361597 2911228 c-Src dependent transactivation of PDGFR contributes to *induced* [MMP-9] expression and functional impairment in osteoblasts . Positive_regulation MMP9 TNF 24361597 2911229 However , the mechanisms underlying [MMP-9] expression *induced* by in osteoblasts remain unclear . Positive_regulation MMP9 TNF 24361597 2911231 Here , we showed that in MC3T3-E1 cells , *induced* [MMP-9] gene expression determined by real-time PCR , zymography , and promoter assay . Positive_regulation MMP9 TNF 24361597 2911255 In addition , *induced* [MMP-9] promoter activity was mediated through an AP-1 binding domain of the MMP-9 promoter region . Positive_regulation MMP9 TNF 24361597 2911271 These results suggested that *induced* [MMP-9] expression is mediated through a c-Src dependent PDGFR transactivation and PI3K/Akt cascade linking to MAPK mediated activation of AP-1 ( c-Jun/ATF2 ) and leading to functional impairment in osteoblasts . Positive_regulation MMP9 TNF 24502696 2914076 However , the mechanisms underlying [MMP-9] expression *induced* by in MC3T3-E1 cells remain unclear . Positive_regulation MMP9 TNF 24502696 2914079 Here we demonstrated that *induced* [MMP-9] expression was attenuated by Act.D , CHI , PP1 , U0126 , SB202190 , SP600125 , and Bay11-7082 , and by the transfection with siRNAs for ERK2 , p38 MAPK , and JNK2 . Positive_regulation MMP9 TNF 24502696 2914084 In addition , *induced* [MMP-9] expression may contribute to the production of sICAM-1 by MC3T3-E1 cells . Positive_regulation MMP9 TNF 24667088 2934884 In addition , *led* to an increased [MMP-9] activity in the conditioned medium as well as a nearly 20-fold increase in mRNA for MMP-9 but not for MMP-2 . Positive_regulation MMP9 TNF 7543547 314355 Northern hybridization assays showed pretranslational control of PMA- , basic fibroblast growth factor- , and *induced* [MMP] expression . Positive_regulation MMP9 TNF 7802656 284525 In contrast , in uninfected cells down *regulated* [gelatinase B] mRNA level , without affecting the gelatinase A . Positive_regulation MMP9 TNF 8045973 266928 Both interleukin-1 alpha and *stimulated* the secretion of MMP-1 , MMP-3 , and [MMP-9] , but not MMP-2 , from the cells in a concentration dependent manner . Positive_regulation MMP9 TNF 8139259 252060 However , keratinocyte [MMP-9] production was *enhanced* by interleukin-1 beta , transforming growth factor beta-1 , and . Positive_regulation MMP9 TNF 8204888 261130 Thus , [MMP-9] secretion may be *regulated* by not only in a paracrine but also in an autocrine fashion . Positive_regulation MMP9 TNF 8226872 235252 Binding sites for NF-kB , Sp-1 , and AP-1 are reportedly required for *induction* of [MMP-9] gene expression by or 12-O-tetradecanoylphorbol-13-acetate . Positive_regulation MMP9 TNF 8314909 220188 also *induced* the production of [MMP-9] by TPA untreated U937 cells without morphological differentiation . Positive_regulation MMP9 TNF 8556714 347392 ( 0.1-30 ng/ml ) significantly *stimulated* [92 kDa gelatinase] secretion in a dose dependent manner , but did not significantly stimulate 72 kDa gelatinase secretion . Positive_regulation MMP9 TNF 8772198 379416 *induces* [pro-matrix metalloproteinase 9] production in human uterine cervical fibroblasts but interleukin 1alpha antagonizes the inductive effect of TNFalpha . Positive_regulation MMP9 TNF 8892653 392142 and IL-1beta selectively *induce* expression of [92-kDa gelatinase] by human macrophages . Positive_regulation MMP9 TNF 8892653 392145 IFN-gamma suppressed the production of the [92-kDa gelatinase] *induced* by and IL-1beta . Positive_regulation MMP9 TNF 8892653 392147 and IL-1beta *regulated* the expression of [92-kDa gelatinase] by monocyte derived macrophages at the pretranslational level . Positive_regulation MMP9 TNF 9014820 405425 In support of this result , stimulation *induced* membrane-type matrix metalloproteinase ( [MT-MMP] ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation MMP9 TNF 9130458 426869 This study examined the *role* of IFN-gamma and ( + ) in the regulation of the matrix metalloproteinases , MMP-2 ( 72 kD gelatinase A ) and [MMP-9] ( 92 kD gelatinase B ) . Positive_regulation MMP9 TNF 9357863 462077 Divergent regulation of [92-kDa gelatinase] and TIMP-1 by HBECs in *response* to IL-1beta and . Positive_regulation MMP9 TNF 9543636 498196 A phorbol mitogen ( TPA ) , and and beta , interleukin-1 alpha and PDGF BB *stimulate* [gelatinase B] , stromelysin , interstitial collagenase and TIMP-1 expression , while having negligible effects on gelatinase A expression ; Positive_regulation MMP9 TNF 9558121 500111 Recombinant and IL-1beta added directly to mucosal mesenchymal cell lines also *caused* an increase in [MMP] production , but only the former was inhibited by the TNFR-IgG . Positive_regulation MMP9 TNF 9622599 511271 We showed that IL-1 and both *induced* gene expression and protein secretion of [Gel B] in both cell lines , as revealed by RT-PCR and gelatin zymography , respectively . Positive_regulation MMP9 TNF 9622599 511277 Taken together , these data suggest that IL-1 , and TGFbeta2 tightly *regulate* [Gel B] secretion in glioma cells , an enzyme which is believed to play an important role in the local invasion of brain tissue by tumor cells . Positive_regulation MMP9 TNF 9631748 512577 *increased* the total [MMP] activity released . Positive_regulation MMP9 TNF 9631748 512578 Moreover , as well as IL-1 beta *induced* the expression of [MMP9] . Positive_regulation MMP9 TNF 9665201 518400 Whereas 12-O-tetradecanoylphorbol-13 acetate ( TPA ) increased both MMP-9 and TIMP-1 mRNA levels , *stimulated* only [MMP-9] gene expression in a dose- and time dependent manner . Positive_regulation MMP9 TNF 9679762 520881 The TNF alpha induced migration through gelatin appeared to be associated with the gelatinolytic activity from the cells , since strongly *enhanced* the production of [matrix metalloproteinase (MMP)-9/gelatinase] B in the SCC cells , as detected by gelatin zymography . Positive_regulation MMP9 TNF 9743373 532503 , granulocyte-macrophage-CSF (GM-CSF) , or IL-1 beta when added individually *enhanced* the endogenous levels of [92-kDa gelatinase] ( MMP-9 ) and TIMP-1 but failed to induce interstitial collagenase ( MMP-1 ) . Positive_regulation MMP9 TNF 9878537 557762 IFNgamma caused a significant dose dependent inhibition in the *stimulated* expression of [MMP-9] . Positive_regulation MMP9 TNF 9917505 587601 Further , *induced* [MMP-9] expression was completely blocked with neutralizing antibody to TNF-alpha , thereby demonstrating the specificity . Positive_regulation MMP9 TNF 9917505 587602 In addition , the *induction* of [MMP-9] expression by was completely abrogated in the presence of cycloheximide , a protein synthesis inhibitor , suggesting that de novo protein synthesis may be required . Positive_regulation MMP9 TNF 9927150 588426 In general , *stimulated* both [MMP] and TIMP expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation MMP9 TNF 9933437 589415 This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when [MMP] production was *up-regulated* by IL-1beta and or down-regulated by IFN-gamma . Positive_regulation MMP9 TNFSF10 18397859 1893690 can *stimulate* the expression of uPA , IL-8 , MMP-7 and [MMP-9] in pancreatic cancer cell lines , especially in Colo357wt . Positive_regulation MMP9 TNFSF10 18397859 1893693 The members of caspases , MEK1/2 , PKC , and NF-kappaB are involved in *induced* expression of uPA , IL-8 , MMP-7 and [MMP-9] . Positive_regulation MMP9 TNFSF10 18834856 1981664 *induces* [MMP-9] expression via ERK activation in human astrocytoma cells . Positive_regulation MMP9 TNFSF10 18834856 1981666 We demonstrated that *induces* [MMP-9] expression in human astrocytoma cells , which is preceded by activation of extracellular signal regulated protein kinase ( ERK ) . Positive_regulation MMP9 TNFSF10 18834856 1981671 The specific MEK inhibitor , U0126 , significantly blocks mediated NF-kappaB activation and subsequent [MMP-9] *induction* . Positive_regulation MNAT1 CAPN8 12859671 1110957 Although Abeta peptides have been suggested to activate *mediated* cleavage of [p35] to p25 in cultured neurons , p25 levels in brains of TgCRND8 mice , which express high levels of brain Abeta peptides , were similar to those of non-Tg littermates . Positive_regulation MNAT1 CAPN8 16407116 1513349 Increased activity in sensory neurons after inflammation *resulted* in the cleavage of [p35] to p25 , which forms a more stable complex with Cdk5 and , consequently , leads to elevation of Cdk5 activity . Positive_regulation MNAT1 EPHB2 11331872 808912 *induces* [p35] , a neuron-specific activator of Cdk5 , through induction of Egr1 . Positive_regulation MNAT1 EPHB2 11331872 808915 Our results indicate that sustained activation of is *necessary* and sufficient for strong induction of [p35] . Positive_regulation MNAT1 NES 12832492 1105740 Ectopic expression of cdk5 and [p35] in central nervous system progenitor cells and in myogenic precursor cells *induced* elevated phosphorylation and reorganization of . Positive_regulation MNAT1 NES 21346193 2420578 *regulated* the cleavage of the Cdk5 activator protein [p35] to its degradation-resistant form , p25 . Positive_regulation MNAT1 TNF 16874302 1600740 Upon *stimulation* of the cells by , NF-kappaB and [TFIIH] are rapidly recruited to the promoter together with additional Mediator and RNAP II , but CDK8 is lost . Positive_regulation MOCOS CCND1 9083291 420987 PDGF stimulation of [MCs] *induced* protein expression of the G1 phase as well as the cyclin dependent kinases cdk 4 and cdk 2 . Positive_regulation MOCOS EPHB2 18606698 1935790 Furthermore , inhibition of MAPKs p38 and *reduces* activation of [MCs] by Hly ( + ) E. coli . Positive_regulation MOCOS IGFBP1 10792618 689460 *Stimulation* of [MCs] with induces rapid actin reorganization and loss of peripheral focal adhesions . Positive_regulation MOCOS MAP2K6 17579558 1763982 In enucleated oocytes , the [Mos] level was dramatically decreased , and both and MAPK dephosphorylation were also *induced* . Positive_regulation MOCOS TNF 11532095 854034 As a marker of factor V activity with exogenous factor Xa , fibrin production on *stimulated* [MCs] was increased in a time dependent manner and was inhibited by the addition of anti-factor V antibody . Positive_regulation MOCOS TNF 22502799 2618341 Using SP-A ( -/- ) Kit ( W-sh/W-sh ) mice engrafted with TNF-a ( -/- ) or TNF receptor (TNF-R) ( -/- ) MCs , we found that TNF-a *activation* of [MCs] through the , but not MC-derived TNF-a , leads to augmented AHR during M pneumoniae infection when SP-A is absent . Positive_regulation MOCOS TNF 22819042 2634987 Unlike normal cells , [MCs] expressing mutant Nlrp3 produced IL-1ß in *response* to lipopolysaccharide or . Positive_regulation MOCOS TNF 23882756 2821424 Besides , LP25-ACA [MCs] *induced* the secretion of and interleukin-6 (IL-6) from macrophages and dendritic cells showing the immunomodulatory effect of LP25 . Positive_regulation MOK EPHB2 12962137 1138500 This culture condition also dose-dependently increased the expression of [RAGE] and the *activation* of . Positive_regulation MOK IL1B 18523305 1922900 Chondrocyte [RAGE] expression and S100A11 release are *stimulated* by in vitro and increase in OA cartilage in situ . Positive_regulation MOK IL1B 19564763 2099720 The [RAGE] expression was significantly *increased* by 2 days ' stimulation of . Positive_regulation MOK S100B 12781351 1095674 [RAGE] expression by neuronal cells or neuronal precursors and its *activation* by may promote their survival . Positive_regulation MOK S100B 16551628 1555603 Here we report that non-receptor Src tyrosine kinase and the membrane protein caveolin-1 (Cav-1) play a key role in the *activation* of [RAGE] by in VSMCs . Positive_regulation MOK S100B 17327432 1706602 LR-90 significantly inhibited *induced* expression of [RAGE] and other proinflammatory genes including monocyte chemoattractant protein-1 , interferon-gamma-inducible protein-10 , and cyclooxygenase-2 in a dose dependent manner . Positive_regulation MOK S100B 17660747 1780444 Structural and functional insights into [RAGE] *activation* by multimeric . Positive_regulation MOK S100B 17660747 1780445 The structural and the binding data suggest that tetrameric *triggers* [RAGE] activation by receptor dimerisation . Positive_regulation MOK S100B 18331229 1840136 Oligomerization of S100 proteins under the non reducing , high-Ca2+ conditions found extracellularly appears to play a relevant role in RAGE activation , and binding of at least S100A12 and *results* in [RAGE] oligomerization . Positive_regulation MOK S100B 18945900 1978261 These results suggest [RAGE] *activation* by enhances the gamma oscillations . Positive_regulation MOK S100B 21889514 2539105 In [RAGE] overexpressing myocytes , ( 100 nM ) *resulted* in increases in VEGF mRNA , VEGF protein , VEGF secretion , and activation of the transcription factor NF-?B . Positive_regulation MOK S100B 23719262 2811569 Although expression *induced* [RAGE] in vivo , RAGE ablation in mice did not significantly inhibit TAM infiltration into gliomas , suggesting that other pathways were involved in this process . Positive_regulation MOK TNF 15893388 1419721 , a proinflammatory cytokine , is a potent *inducer* of [RAGE] expression in endothelial cells . Positive_regulation MOK TNF 15893388 1419722 The gp91phox subunit of NADPH oxidase appears to be the source of ROS that induces *dependent* mitochondrial ROS generation and subsequent [RAGE] expression . Positive_regulation MOK TNF 16888237 1613912 Stimulation of human endothelial cells with candesartan as well as olmesartan decreased *induced* [RAGE] expression in both mRNA and protein levels along with the decrease in the activity of nuclear factor kappaB and the expression of inflammatory mediators such as vascular cell adhesion molecule (VCAM)-1 . Positive_regulation MOK TNF 20951562 2424754 FBS incubated with MG and CA ( MG/CA-FBS ) evoked the greatest deleterious responses , as follows : ( 1 ) inducing proinflammatory tumor necrosis factor (TNF)-a and interleukin-1ß expression and ROS production in monocytic THP-1 cells , ( 2 ) stimulating secretion in RAW 264.7 macrophages and ( 3 ) causing oxidative DNA damage and *inducing* the expression of [receptor for AGEs (RAGE)] , intercellular adhesion molecule-1 ( ICAM-1 ) and vascular cell adhesion molecule-1 in human umbilical vein endothelial cells . Positive_regulation MORF4L1 TMPRSS4 23821596 2834521 In cultured cells , we show that levels of chromatin bound protein are partially dependent on Mrg15 and that Cap-H2 mediated homolog unpairing is *suppressed* by RNA interference depletion of [Mrg15] . Positive_regulation MPC1 CAPN8 8158145 253448 The chymotrypsinlike activity ( cleavage after hydrophobic amino acids ) and the caseinolytic activity ( degradation of beta-casein ) of [MPC] were strongly *inhibited* by inhibitors 1 and 2 ( IC50 values in the low micromolar range ) . Positive_regulation MPC1 IFI27 24097312 2888730 Inhibitors of MPC , Cytochalasin D and amiloride , decreased P27 mediated uptake of soluble dextran and inhibited P27 induced virus uptake by > 60 % , which provides further evidence that *induces* [MPC] . Positive_regulation MPC2 CAPN8 8158145 253462 The chymotrypsinlike activity ( cleavage after hydrophobic amino acids ) and the caseinolytic activity ( degradation of beta-casein ) of [MPC] were strongly *inhibited* by inhibitors 1 and 2 ( IC50 values in the low micromolar range ) . Positive_regulation MPC2 IFI27 24097312 2888731 Inhibitors of MPC , Cytochalasin D and amiloride , decreased P27 mediated uptake of soluble dextran and inhibited P27 induced virus uptake by > 60 % , which provides further evidence that *induces* [MPC] . Positive_regulation MPG TNF 1628418 191789 [Kp-MPG] *induced* the synthesis of IL-1 beta , IL-6 and with dose-responses and kinetics similar to those of Salmonella minnesota lipopolysaccharide ( Sm-Re-LPS ) . Positive_regulation MPL TNF 22191632 2543442 Meanwhile , compared with the control group , not only the mRNA expressions of , interleukin-6 (IL-6) , and interferon-? ( IFN-? ) in macrophages , but also the productions of proteins , were strongly *induced* by [MPL] ; Positive_regulation MPL TNF 22829882 2635398 We also observed that [MPL] *induced* high production of IL-2 , , and IFN-? , in addition to IL-6 , IL-17 , and IL-10 . Positive_regulation MPL TNF 3135314 95789 These results suggest that the non-toxic [MPL] as well as the toxic forms of lipid A can *induce* the production of by macrophages . Positive_regulation MPO ARSA 21415093 2469778 Although [myeloperoxidase (MPO)] activity was *increased* by , it was found to be lower in the ASA plus SC group . Positive_regulation MPO CLU 9724257 529391 Both exogenous PAF and induced significant *increases* in [MPO] activity in the stomach and duodenum . Positive_regulation MPO IL1B 19067146 2024082 The TNBS treatment caused colon shortening , increased [myeloperoxidase] activity , *induced* , TNF-alpha , and IL-6 expression in the colon , activated NF-kappaB , and potentiated the GAG degrading activities of intestinal microflora . Positive_regulation MPO IL1B 19429354 2077614 Production of pro-inflammatory cytokines ( TNF-alpha and ) , *activation* of [myeloperoxidase] , and histological assessment were examined in acute and chronic skin inflammation using 12-O-tetradecanoyl-phorbol-13-acetate ( TPA ) -induced mouse ear edema . Positive_regulation MPO IL1B 9990535 560344 Pre-treatment with SLeX-OS ( a novel oligosaccharide analog of sialyl LewisX ) or PB1 .3 ( a monoclonal antibody to P-selectin ) prevented the myocardial dysfunction and significantly suppressed the neutrophil infiltration and the increase in myocardial [MPO] activity *induced* by ( P < 0.01 each ) . Positive_regulation MPO ITGB2 10409195 629871 however , *had* no effect on intestinal or hepatic F ( 2 ) -isoprostane levels or on pulmonary [MPO] activity . Positive_regulation MPO ITGB2 17372166 1713759 By flow cytometry , radioactive binding assays , and immunoprecipitation , we demonstrate that CD40L interacts with the integrin Mac-1 , which results in *dependent* adhesion and migration of inflammatory cells as well as [myeloperoxidase] release in vitro . Positive_regulation MPO TNF 10699463 672115 *Role* of in regulation of [myeloperoxidase] expression in irradiated HL60 promyelocytic cells . Positive_regulation MPO TNF 16269189 1502330 Control , but not capsaicin pretreated rats ( to deplete sensory nerves ) , exhibited a marked increase in [MPO] activity in *response* to . Positive_regulation MPO TNF 16490933 1528618 [MPO-ANCA] increased slightly at 4 and markedly at 9 weeks , and the level *increased* at 11 weeks . Positive_regulation MPO TNF 16575489 1671874 The spontaneous membrane expression of [MPO] and PR3 on PMN could be significantly *increased* by lipopolysaccharide (LPS) and , but not by IL-8 or GRO-alpha . Positive_regulation MPO TNF 18691647 2011748 Production of pro-inflammatory cytokines ( , interleukin (IL)-1beta ) , *activation* of [myeloperoxidase] , and histological assessment were examined in acute and chronic skin inflammation using 12-O-tetradecanoyl-phorbol-13-acetate ( TPA ) -induced mouse ear edema . Positive_regulation MPO TNF 19067146 2024081 The TNBS treatment caused colon shortening , increased [myeloperoxidase] activity , *induced* IL-1beta , , and IL-6 expression in the colon , activated NF-kappaB , and potentiated the GAG degrading activities of intestinal microflora . Positive_regulation MPO TNF 19429354 2077613 Production of pro-inflammatory cytokines ( and IL-1 beta ) , *activation* of [myeloperoxidase] , and histological assessment were examined in acute and chronic skin inflammation using 12-O-tetradecanoyl-phorbol-13-acetate ( TPA ) -induced mouse ear edema . Positive_regulation MPO TNF 20167660 2236400 Niacin also inhibited intima-media neutrophil recruitment and [myeloperoxidase] accumulation , enhanced endothelial dependent vasorelaxation and cyclic guanosine monophosphate production , increased vascular reduced glutathione content , and protected against hypochlorous acid induced endothelial dysfunction and alpha *induced* vascular inflammation . Positive_regulation MPO TNF 20230179 2339393 Production of proinflammatory cytokines ( IL-1ß and ) , *activation* of [myeloperoxidase (MPO)] , and histological indicators were examined in acute and chronic skin inflammation using 12-O-tetradecanoyl-phorbol-13-acetate ( TPA ) -induced mouse ear edema . Positive_regulation MPO TNF 22036766 2540027 *led* to significant increase in [myeloperoxidase] ( MPO , an index of neutrophils infiltration ) , nitrites ( stable nitric oxide metabolites ) and malondialdehyde ( MDA , a marker of lipid peroxides ) levels and cell apoptosis in liver and colon . Positive_regulation MPP1 TNF 10414455 631053 Human binds to and *activates* the murine [p55] receptor , but not the p75 receptor . Positive_regulation MPP1 TNF 11535512 854708 *mediated* activation of the [p55] TNF receptor negatively regulates maintenance of cycling reconstituting human hematopoietic stem cells . Positive_regulation MPRIP TNF 23612963 2795312 We found that *induces* Thr-231 and Ser-232 phosphorylation in [mouse RIP3 (mRIP3)] and this phosphorylation is required for mRIP3 to interact with mMLKL . Positive_regulation MRAP TNF 10717805 676648 The results of differential linkage disequilibrium with HLA-B27 subtypes suggest that [B27] itself remains the primary gene for AS susceptibility , and and MICA are not *involved* in the pathogenesis of the disease . Positive_regulation MRAP TNF 15265899 1275512 [B27] ( 2 ) can *induce* release from the J774 . Positive_regulation MRAP TNF 23338610 2775684 Also , we report for the first time that HER2/neu ( ERBB2 ) , EGF , and *promote* [miR-23b/27b] expression through the AKT/NF-?B signaling cascade . Positive_regulation MRC1 TNF 9990294 597302 In *stimulated* [MRC-5] cells , DNA binding and competition experiments indicated that the predominant NF-kappa B binding activity detected with nuclear extract stimulated cells is mediated by the p50/p65 complex . Positive_regulation MRC2 PLAU 12952933 1137484 The constitutively recycling endocytic receptor [Endo180] forms a trimolecular complex with uPAR in the *presence* of , hence its alternate name uPAR associated protein . Positive_regulation MRC2 TNF 9990294 597301 In *stimulated* [MRC-5] cells , DNA binding and competition experiments indicated that the predominant NF-kappa B binding activity detected with nuclear extract stimulated cells is mediated by the p50/p65 complex . Positive_regulation MRE11A EPHB2 15178807 1280492 TPA treatment rapidly increased phosphorylation of , a reported downstream effector of both PKC and Rap1 , in ERC-18 cells , but induced weak [Rap1] *activation* . Positive_regulation MRE11A F2R 15078882 1251882 We found that , similarly to thrombin , selective stimulation of either or PAR-4 by specific activating peptides *caused* accumulation of GTP bound [Rap1B] in a dose dependent manner . Positive_regulation MRE11A F2R 15078882 1251896 In the presence of the ADP scavengers apyrase or phosphocreatine-phosphocreatine kinase , activation of [Rap1B] *induced* by stimulation of either or PAR-4 was totally inhibited . Positive_regulation MRE11A F2R 19483102 2107933 Perturbation of PI3K signaling by isoform-selective inhibitors had differential effects on [Rap1] *activation* through and PAR4 . Positive_regulation MRE11A F2R 24790104 2950506 Stimulation of the G-protein coupled receptor with thrombin in human 1321N1 glioblastoma cells *led* to a robust increase in [Rap1] activation . Positive_regulation MRE11A TNF 16043520 1437851 Both compounds blocked *induced* activation of [Rap1A] , a phox associated guanosine triphosphatase that is regulated by cAMP . Positive_regulation MRPL41 TP63 18331776 1904686 The results of western blot analysis further showed that increases of and p73 protein translation or stability might be *contribute* to the regulation of GADD45beta , 14-3-3sigma , cyclin B1 and [PIG3] . Positive_regulation MRT10 CCND1 20179200 2215803 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Positive_regulation MRT11 CCND1 20179200 2215806 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Positive_regulation MRT12 CCND1 20179200 2215809 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Positive_regulation MRT17 CCND1 20179200 2215791 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Positive_regulation MRT18 CCND1 20179200 2215812 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Positive_regulation MRT19 CCND1 20179200 2215815 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Positive_regulation MRT20 CCND1 20179200 2215818 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Positive_regulation MRT21 CCND1 20179200 2215821 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Positive_regulation MRT22 CCND1 20179200 2215824 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Positive_regulation MRT23 CCND1 20179200 2215827 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Positive_regulation MRT24 CCND1 20179200 2215830 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Positive_regulation MRT25 CCND1 20179200 2215833 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Positive_regulation MRT26 CCND1 20179200 2215836 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Positive_regulation MRT27 CCND1 20179200 2215839 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Positive_regulation MRT28 CCND1 20179200 2215842 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Positive_regulation MRT4 CCND1 20179200 2215788 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Positive_regulation MRT5 CCND1 20179200 2215794 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Positive_regulation MRT8 CCND1 20179200 2215797 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Positive_regulation MRT9 CCND1 20179200 2215800 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Positive_regulation MRXS5 IL1B 11717138 881890 Inhibition of protein biosynthesis suggested that the *induced* [PGS-2] gene expression required de novo protein biosynthesis . Positive_regulation MRXS5 IL1B 11717138 881891 Our findings revealed substantial *mediated* stabilization of [PGS-2] transcripts , as assessed by a threefold increase in the half-life of the message . Positive_regulation MRXS5 IL1B 16556676 1562127 The selective COX-2 inhibitor NS-398 completely inhibits the increased production of [PGs] *induced* by in both cell types , whereas dexamethasone ( DEX ) exerts a stronger inhibition in HIESC than in HIEEC . Positive_regulation MRXS5 IL1B 17901089 1888861 The addition of CS to IL1 beta treated cells inhibited in part the disaggregation of sulphated [PGs] *induced* by . Positive_regulation MRXS5 TNF 10570310 568424 Indeed , dPGJ2 blocked adhesion of neutrophils to fibrinogen in *response* to or LPS with an IC50 of 3-5 micro+dPGJ2 was more potent at inhibiting the adhesion dependent oxidative burst than several other [PGs] tested . Positive_regulation MRXS5 TNF 11162356 782137 These cells exhibit many of the properties of villous or extravillous trophoblasts and produce large amounts of [PGs] in *response* to . Positive_regulation MRXS5 TNF 15171698 1253771 The inhibitory effect of TNF-alpha on the LH surge was blocked by pretreatment with indomethacin , suggesting that the effects of were *mediated* by [prostaglandins (PGs)] . Positive_regulation MRXS5 TNF 15226598 1268862 When the cells were exposed to TNFalpha in combination with NOS inhibitor ( L-NAME ) , *stimulated* [PGs] production was reduced ( P < 0.05 ) . Positive_regulation MRXS5 TNF 17107518 1645102 Summarizing , *induces* both [PGs] secretion from cultured porcine endometrium , but preferentially stimulates PGF ( 2alpha ) release from luminal epithelial cells . Positive_regulation MRXS5 TNF 22187328 2537221 and IL-1a slightly *increased* the release of ( 35 ) [S-PGs] to the culture medium , whereas IL-1ß treatment gave a significant increase . Positive_regulation MS CD14 17046070 1649382 The aim of this study was to evaluate a possible *role* of soluble ( sCD14 ) in [multiple sclerosis (MS)] . Positive_regulation MS CLU 7730444 302330 Thus , TGF-beta 1 and heterotypic cell interactions influence clusterin expression by astrocytes and may be important to the *role* of in [multiple sclerosis] , AIDS , and Alzheimer 's disease . Positive_regulation MS MMP28 12620642 1066268 In [multiple sclerosis (MS)] , activity in tissues is the *result* of a balance between MMPs and their tissue inhibitors ( TIMPs ) . Positive_regulation MS MMP7 12620642 1066283 In [multiple sclerosis (MS)] , activity in tissues is the *result* of a balance between MMPs and their tissue inhibitors ( TIMPs ) . Positive_regulation MS TLR7 19837184 2216973 An increasing body of circumstantial evidence implicates a *role* of signalling in systemic lupus erythematosus ( SLE ) , atherosclerosis , asthma , type 1 diabetes , [multiple sclerosis] , bowl inflammation and rheumatoid arthritis ( RA ) . Positive_regulation MS TNF 10652446 663192 The precise *role* of in [multiple sclerosis (MS)] is still controversial . Positive_regulation MS TNF 9050957 417099 The decrease in levels and the increase in `` suppressor-inducer '' lymphocytes could *reduce* chronic inflammation in [multiple sclerosis] , and paralleled an overall favourable clinical response to azathioprine treatment in our patients . Positive_regulation MS4A1 EPHB2 15944291 1416157 Cells pretreated with bryostatin-1 were more susceptible to the proapoptotic effect of anti-CD20 Ab. Overall , these data demonstrate for the first time that phosphorylation is *required* for the up-regulated expression of [CD20] on B cell malignancies . Positive_regulation MS4A1 FAS 12850790 1109582 Here , newly developed suicide genes , including *inducible* , inducible caspase and [CD20] are discussed . Positive_regulation MS4A8 TLR7 22806454 2692042 Innate immunity in these infections is modulated by signaling and TLR2/4/7 agonists strongly *induced* [Ms4a8a] expression in bone marrow derived macrophages ( BMDMs ) treated with M2 mediators ( glucocorticoids/IL-4 ) . Positive_regulation MSC ANGPT1 18565279 1929498 This study showed that [MSC] expressed Tie-2 receptor , and *induced* Tie-2 receptor phosphorylation . Positive_regulation MSC CCL17 21867464 2490982 Human [MSC] were *stimulated* by ( CCL15 ) /macrophage inflammatory protein ( MIP-5 ) , CCL19/MIP-3ß chemokine (C-X-C motif) ligand ( CXCL8 ) /interleukin (IL)-8 , CXCL12/ stromal derived factor ( SDF-1 ) or CXCL13/B lymphocyte chemoattractant (BLC) . Positive_regulation MSC IL1B 16365420 1504930 <4T1/IL-1beta> *induced* [MSC] do not express the IL-1R , suggesting that the cytokine does not directly activate MSC . Positive_regulation MSC IL1B 16365420 1504931 Neither T or B cells nor NKT cells are involved in the *induced* increase of [MSC] because RAG2-/- mice and nude mice with 4T1/IL-1beta tumors also have elevated MSC levels . Positive_regulation MSC TLR7 19494321 2091670 We observed that human MSC and macrophages expressed TLR3 and TLR4 at comparable levels and *mediated* activation of [MSC] resulted in the production of inflammatory mediators such as IL-1beta , IL-6 , IL-8/CXCL8 , and CCL5 . Positive_regulation MSC TLR7 21700275 2465489 ligation *increased* the production of inflammatory cytokines in BM- and AT-MSC but not in [WJ-MSC] and augmented anti-inflammatory cytokines in AT-MSC . Positive_regulation MSC TNF 20429787 2307460 released from papain treated lung cells *induces* [MSC] to secret VEGF-A . Positive_regulation MSC TNF 22803811 2682158 *Stimulation* of [MSC] with exogenous a and interferon ( IFN ) ? prior to infusion could not rescue BM-transplanted rats from lethal acute GVHD . Positive_regulation MSH2 IL1B 17525125 1778366 We further show that increases the frequency of action potentials of ARC POMC neurons and *stimulates* the release of [alpha-MSH] from hypothalamic explants in a dose dependent fashion . Positive_regulation MSH2 PGC 23201126 2724057 [a-MSH] signaling strongly *induces* expression and stabilizes both PGC-1a and PGC-1ß proteins . Positive_regulation MSH3 IL1B 11025451 738538 *Induction* of [MRP1] and gamma-glutamylcysteine synthetase gene expression by is mediated by nitric oxide related signalings in human colorectal cancer cells . Positive_regulation MSH3 IL1B 11025451 738545 Collectively , our results demonstrate that *induction* of [MRP1] and gamma-GCSh by is regulated , at least in part , by an NO-related signaling , and induction of gamma-GCSh is by NO-related ceramide signaling . Positive_regulation MSH3 IL1B 17525125 1778367 We further show that increases the frequency of action potentials of ARC POMC neurons and *stimulates* the release of [alpha-MSH] from hypothalamic explants in a dose dependent fashion . Positive_regulation MSH3 IL1B 20231161 2265933 In addition , and estrone are able to *enhance* [MRP1] gene expression and influence extracellular cAMP concentration . Positive_regulation MSH3 PGC 23201126 2724058 [a-MSH] signaling strongly *induces* expression and stabilizes both PGC-1a and PGC-1ß proteins . Positive_regulation MSH3 TNF 20051532 2225365 In primary cultures of rat astrocytes , [Mrp1] expression was *increased* by ( 2.7-fold ) but was not altered by IL-1 beta or IL-6 . Positive_regulation MSH3 TNF 20051532 2225369 In contrast , [Mrp1] functional expression was not altered in the *presence* of gp120 or when astrocyte cultures were pretreated with 1,9-pyrazoloanthrone ( SP600125 ) , an established c-Jun N-terminal kinase (JNK) inhibitor . Positive_regulation MSH4 IL1B 17525125 1778368 We further show that increases the frequency of action potentials of ARC POMC neurons and *stimulates* the release of [alpha-MSH] from hypothalamic explants in a dose dependent fashion . Positive_regulation MSH4 PGC 23201126 2724059 [a-MSH] signaling strongly *induces* expression and stabilizes both PGC-1a and PGC-1ß proteins . Positive_regulation MSH5 IL1B 17525125 1778369 We further show that increases the frequency of action potentials of ARC POMC neurons and *stimulates* the release of [alpha-MSH] from hypothalamic explants in a dose dependent fashion . Positive_regulation MSH5 PGC 23201126 2724060 [a-MSH] signaling strongly *induces* expression and stabilizes both PGC-1a and PGC-1ß proteins . Positive_regulation MSH6 IL1B 17525125 1778370 We further show that increases the frequency of action potentials of ARC POMC neurons and *stimulates* the release of [alpha-MSH] from hypothalamic explants in a dose dependent fashion . Positive_regulation MSH6 PGC 23201126 2724061 [a-MSH] signaling strongly *induces* expression and stabilizes both PGC-1a and PGC-1ß proteins . Positive_regulation MSK10 EPHB2 17329213 1706679 In juvenile mice , visual stimulation that activates CREB mediated gene transcription also induced *dependent* [MSK] and histone H3 phosphorylation and H3-H4 acetylation , an epigenetic mechanism of gene transcription activation . Positive_regulation MSK32 EPHB2 17329213 1706680 In juvenile mice , visual stimulation that activates CREB mediated gene transcription also induced *dependent* [MSK] and histone H3 phosphorylation and H3-H4 acetylation , an epigenetic mechanism of gene transcription activation . Positive_regulation MSK38 EPHB2 17329213 1706681 In juvenile mice , visual stimulation that activates CREB mediated gene transcription also induced *dependent* [MSK] and histone H3 phosphorylation and H3-H4 acetylation , an epigenetic mechanism of gene transcription activation . Positive_regulation MSK9 EPHB2 17329213 1706682 In juvenile mice , visual stimulation that activates CREB mediated gene transcription also induced *dependent* [MSK] and histone H3 phosphorylation and H3-H4 acetylation , an epigenetic mechanism of gene transcription activation . Positive_regulation MSN TNF 19965872 2199597 *promoted* CD44 expression and [moesin] phosphorylation by protein kinase C , leading to the pericellular interaction of hyaluronan and CD44 . Positive_regulation MST1 STK39 10586055 571693 Here we demonstrate that expression of in RAW264.7 cells *resulted* in suppression of NO production following IFN-gamma+/- LPS stimulation in the presence of [MSP] , reflecting a decrease in the levels of inducible NO synthase (iNOS) mRNA and protein , which was confirmed by decreased trans-activation of an iNOS reporter . Positive_regulation MST1 STK39 11748211 898106 Here we demonstrate that , although [MSP] *activation* of inhibits NO production by macrophages in response to heat killed Listeria monocytogenes , STK-deficient mice exhibit increased susceptibility to infection with Listeria . Positive_regulation MSTN CCND1 17130121 1693423 [Myostatin] *induces* degradation to cause cell cycle arrest through a phosphatidylinositol 3-kinase/AKT/GSK-3 beta pathway and is antagonized by insulin-like growth factor 1 . Positive_regulation MSTN EPHB2 20568119 2320364 Pretreatment with p38 MAPK ( SB203580 ) and JNK ( SP600125 ) inhibitors , but not ( PD98059 ) inhibitor , *blocked* TSA induced [myostatin] expression , respectively , by 72 % and 43 % . Positive_regulation MSTN FBXO32 18542002 1923581 Molecular analyses reveal that excess levels of [myostatin] *induce* expression by reducing Akt phosphorylation and thereby increasing FoxO1 activity . Positive_regulation MSTN PGC 23217713 2707902 Rather , it specifically induces IGF1 and represses [myostatin] , and expression of in vitro and in vivo *induces* robust skeletal muscle hypertrophy . Positive_regulation MSTN TNF 19218333 2050177 In differentiated C2C12 cells , *induced* the expression of [myostatin] through a p38MAPK dependent pathway involving nuclear factor kappa-B (NF-kappaB) . Positive_regulation MSTN TNF 21282204 2419793 In cultured muscle cells , *increased* [myostatin] expression via a NF-?B dependent pathway , whereas muscle cells exposed to myostatin stimulated IL-6 production via p38 MAPK and MEK1 pathways . Positive_regulation MSTN TNF 21771249 2500278 Additionally , our results indicate that both and hydrogen peroxide ( H ( 2 ) O ( 2 ) ) are potent *inducers* of [Mstn] and require NF-?B signaling for Mstn induction . Positive_regulation MSX1 BMP1 10954731 724621 In chick mandibles , exogenous *induces* [Msx] expression and together with fibroblast growth factor promotes the development of Sonic hedgehog expressing epithelial structures . Positive_regulation MSX1 BMP1 14627721 1176400 All the results show that a reduction in the level of activity *leads* to an increase in the expression of [Msx] genes in the neural plate border . Positive_regulation MSX1 BMP1 15936012 1427426 Furthermore , our data uncovered different Bmp4 thresholds for expression of the *dependent* [Msx1] and Msx2 genes in mandibular mesenchyme . Positive_regulation MSX1 BMP1 17030628 1649044 *induced* [MSX1] and MSX2 inhibit myocardin dependent smooth muscle gene transcription . Positive_regulation MSX1 BMP10 10954731 724629 In chick mandibles , exogenous *induces* [Msx] expression and together with fibroblast growth factor promotes the development of Sonic hedgehog expressing epithelial structures . Positive_regulation MSX1 BMP10 14627721 1176408 All the results show that a reduction in the level of activity *leads* to an increase in the expression of [Msx] genes in the neural plate border . Positive_regulation MSX1 BMP10 15936012 1427434 Furthermore , our data uncovered different Bmp4 thresholds for expression of the *dependent* [Msx1] and Msx2 genes in mandibular mesenchyme . Positive_regulation MSX1 BMP10 17030628 1649052 *induced* [MSX1] and MSX2 inhibit myocardin dependent smooth muscle gene transcription . Positive_regulation MSX1 BMP15 10954731 724622 In chick mandibles , exogenous *induces* [Msx] expression and together with fibroblast growth factor promotes the development of Sonic hedgehog expressing epithelial structures . Positive_regulation MSX1 BMP15 14627721 1176401 All the results show that a reduction in the level of activity *leads* to an increase in the expression of [Msx] genes in the neural plate border . Positive_regulation MSX1 BMP15 15936012 1427427 Furthermore , our data uncovered different Bmp4 thresholds for expression of the *dependent* [Msx1] and Msx2 genes in mandibular mesenchyme . Positive_regulation MSX1 BMP15 17030628 1649045 *induced* [MSX1] and MSX2 inhibit myocardin dependent smooth muscle gene transcription . Positive_regulation MSX1 BMP2 10954731 724623 In chick mandibles , exogenous *induces* [Msx] expression and together with fibroblast growth factor promotes the development of Sonic hedgehog expressing epithelial structures . Positive_regulation MSX1 BMP2 14627721 1176402 All the results show that a reduction in the level of activity *leads* to an increase in the expression of [Msx] genes in the neural plate border . Positive_regulation MSX1 BMP2 15936012 1427428 Furthermore , our data uncovered different Bmp4 thresholds for expression of the *dependent* [Msx1] and Msx2 genes in mandibular mesenchyme . Positive_regulation MSX1 BMP2 17030628 1649046 *induced* [MSX1] and MSX2 inhibit myocardin dependent smooth muscle gene transcription . Positive_regulation MSX1 BMP3 10954731 724624 In chick mandibles , exogenous *induces* [Msx] expression and together with fibroblast growth factor promotes the development of Sonic hedgehog expressing epithelial structures . Positive_regulation MSX1 BMP3 14627721 1176403 All the results show that a reduction in the level of activity *leads* to an increase in the expression of [Msx] genes in the neural plate border . Positive_regulation MSX1 BMP3 15936012 1427429 Furthermore , our data uncovered different Bmp4 thresholds for expression of the *dependent* [Msx1] and Msx2 genes in mandibular mesenchyme . Positive_regulation MSX1 BMP3 17030628 1649047 *induced* [MSX1] and MSX2 inhibit myocardin dependent smooth muscle gene transcription . Positive_regulation MSX1 BMP4 10954731 724625 In chick mandibles , exogenous *induces* [Msx] expression and together with fibroblast growth factor promotes the development of Sonic hedgehog expressing epithelial structures . Positive_regulation MSX1 BMP4 14627721 1176404 All the results show that a reduction in the level of activity *leads* to an increase in the expression of [Msx] genes in the neural plate border . Positive_regulation MSX1 BMP4 15936012 1427430 Furthermore , our data uncovered different Bmp4 thresholds for expression of the *dependent* [Msx1] and Msx2 genes in mandibular mesenchyme . Positive_regulation MSX1 BMP4 16313398 1486934 Mesenchymal heterogeneity is established early , as evident from *mediated* induction of [Msx1] and cell proliferation exclusively in the anterior and Fgf8-specific induction of Pax9 in the posterior palate alone . Positive_regulation MSX1 BMP4 17030628 1649048 *induced* [MSX1] and MSX2 inhibit myocardin dependent smooth muscle gene transcription . Positive_regulation MSX1 BMP4 19364479 2074579 It has been consistently shown in Xenopus embryos that the depletion of fortilin 's message severely compromises the formation of neural tissue , even in the brain , while overexpression of fortilin induces the partial double body axis in embryos and is capable of blocking *induced* transcription of Vent1 , Vent2 , and [Msx1] genes . Positive_regulation MSX1 BMP4 8817454 384598 Ectopic *induced* [Msx-1] and Msx-2 gene expression in superficial ectoderm and superficial mesodermal cells which normally do not express these transcription factors . Positive_regulation MSX1 BMP4 8861099 388524 To determine if could *activate* [Msx-3] , we incubated embryonic hindbrain explants with exogenous Bmp-4 . Positive_regulation MSX1 BMP4 9477322 486882 *induced* the expression of both Msx1 and Msx2 genes in sutural tissue , while FGF4 induced only [Msx1] . Positive_regulation MSX1 BMP4 9541209 498050 These observations suggest that whereas may be *involved* in activation of [Msx-1] and Msx-2 in the underlying mesenchyme , EGF may regulate events involved in the formation of dental lamina . Positive_regulation MSX1 BMP4 9707326 526353 There is , however , no evidence that is the endogenous *inducer* of [Msx-1] expression . Positive_regulation MSX1 BMP4 9769173 538707 For example , epithelially expressed *induces* [Msx1] and Lef1 as well as itself in the underlying mesenchyme . Positive_regulation MSX1 BMP5 10954731 724626 In chick mandibles , exogenous *induces* [Msx] expression and together with fibroblast growth factor promotes the development of Sonic hedgehog expressing epithelial structures . Positive_regulation MSX1 BMP5 14627721 1176405 All the results show that a reduction in the level of activity *leads* to an increase in the expression of [Msx] genes in the neural plate border . Positive_regulation MSX1 BMP5 15936012 1427431 Furthermore , our data uncovered different Bmp4 thresholds for expression of the *dependent* [Msx1] and Msx2 genes in mandibular mesenchyme . Positive_regulation MSX1 BMP5 17030628 1649049 *induced* [MSX1] and MSX2 inhibit myocardin dependent smooth muscle gene transcription . Positive_regulation MSX1 BMP6 10954731 724627 In chick mandibles , exogenous *induces* [Msx] expression and together with fibroblast growth factor promotes the development of Sonic hedgehog expressing epithelial structures . Positive_regulation MSX1 BMP6 14627721 1176406 All the results show that a reduction in the level of activity *leads* to an increase in the expression of [Msx] genes in the neural plate border . Positive_regulation MSX1 BMP6 15936012 1427432 Furthermore , our data uncovered different Bmp4 thresholds for expression of the *dependent* [Msx1] and Msx2 genes in mandibular mesenchyme . Positive_regulation MSX1 BMP6 17030628 1649050 *induced* [MSX1] and MSX2 inhibit myocardin dependent smooth muscle gene transcription . Positive_regulation MSX1 BMP7 10954731 724628 In chick mandibles , exogenous *induces* [Msx] expression and together with fibroblast growth factor promotes the development of Sonic hedgehog expressing epithelial structures . Positive_regulation MSX1 BMP7 14627721 1176407 All the results show that a reduction in the level of activity *leads* to an increase in the expression of [Msx] genes in the neural plate border . Positive_regulation MSX1 BMP7 15936012 1427433 Furthermore , our data uncovered different Bmp4 thresholds for expression of the *dependent* [Msx1] and Msx2 genes in mandibular mesenchyme . Positive_regulation MSX1 BMP7 17030628 1649051 *induced* [MSX1] and MSX2 inhibit myocardin dependent smooth muscle gene transcription . Positive_regulation MSX1 CISH 7866431 287288 Taken together , both positive and negative regulatory are *involved* in the regulation of the [MSX-1] promoter and coordinate to control the gene expression . Positive_regulation MSX1 DLX5 20824629 2346075 Furthermore , *requires* [Msx1] for its expression in the context of frontal bone development . Positive_regulation MSX1 EGF 10633853 576662 However , in contrast to BMPs , did not *induce* [Msx-1] , Msx-2 , and Bmp-4 , but modulated the effects of BMPs on the expression of Msx-1 and Msx-2 in these mesenchymes . Positive_regulation MSX1 EGF 9541209 498048 does not *induce* [Msx-1] and Msx-2 in dental mesenchyme . Positive_regulation MSX1 FGF4 9477322 486883 BMP4 induced the expression of both Msx1 and Msx2 genes in sutural tissue , while *induced* only [Msx1] . Positive_regulation MSX1 FOXE1 21177256 2385662 The [MSX1] and TGF-ß3 up-regulation in *response* to at both transcriptional and translational levels and the recruitment of FOXE1 to specific binding motifs , together with the transactivation of the promoters of these genes , indicate that MSX1 and TGF-ß3 are direct FOXE1 targets . Positive_regulation MSX1 FOXE1 21777520 2456922 Downregulation of by HR *suppresses* [Msx1] expression in the hair follicles of Hr ( Hp ) mice . Positive_regulation MSX1 GDF11 11203700 785446 Analysis of molecular markers of skeletal patterning revealed that *induced* ectopic expression of Hoxd-11 and Hoxd-13 , but not of Hoxa-11 , Hoxa-13 , or the [Msx] genes . Positive_regulation MSX1 IGF1 8620859 354109 Neither IGF-I , insulin nor FGFs *induce* expression of the homeobox containing gene [Msx-1] in the subapical mesoderm of wl or ll limb buds , although FGFs , but not or insulin , maintain Msx-1 expression in normal ( non-mutant ) limb bud explants lacking an AER . Positive_regulation MSX1 INS 8620859 354110 Neither IGF-I , nor FGFs *induce* expression of the homeobox containing gene [Msx-1] in the subapical mesoderm of wl or ll limb buds , although FGFs , but not IGF-I or insulin , maintain Msx-1 expression in normal ( non-mutant ) limb bud explants lacking an AER . Positive_regulation MSX1 ISL1 12900460 1118752 Inhibition of in distal epithelium *resulted* in a loss of Bmp4 expression and a corresponding loss of [Msx1] expression , indicating that a positive regulatory loop exists between ISL1 and BMP4 in distal epithelium . Positive_regulation MSX1 LMO4 19913004 2197721 Expression analysis of the known otic markers showed that is *essential* for the normal expression of Bmp4 , Fgf10 , [Msx1] , Isl1 , Gata3 , and Dlx5 in the dorsolateral domain of the otocyst , whereas the initial compartmentalization of the otocyst remains unaffected . Positive_regulation MSX1 MSX2 8660900 371781 Low levels of [Msx-1] transcripts were *detected* in glands from lactating animals and during the first days of involution , whereas expression was not detected during lactation or early involution . Positive_regulation MSX1 MSX2 9846382 553892 The expression level increased in the blastema at the early bud stage , and [Msx1] expression level *increased* at the late bud stage . Positive_regulation MSX1 PAX3 15691759 1371430 [Msx1] *induces* and ZicR1 cell autonomously , in turn , Pax3 combined with ZicR1 activates Slug in a WNT dependent manner . Positive_regulation MSX1 PAX9 9732271 530614 At this stage , is *required* for the mesenchymal expression of Bmp4 , [Msx1] , and Lef1 , suggesting a role for Pax9 in the establishment of the inductive capacity of the tooth mesenchyme . Positive_regulation MSX1 PIAS1 16600910 1544998 We show that is *required* for the appropriate localization and retention of [Msx1] at the nuclear periphery in myoblast cells . Positive_regulation MSX1 TBX3 18285513 1911719 Using chromatin immunoprecipitation analysis we demonstrate that Msx1 can bind the Cx43 promoter at a conserved binding site located in close proximity to a previously defined T-box binding site , and that the activity of [Msx] proteins on this promoter appears dependent in the *presence* of . Positive_regulation MSX1 TNF 22685265 2633474 up-regulated Msx2 mRNA 4-fold within 3 h but did not *regulate* [Msx1] . Positive_regulation MSX1 WNT1 12874124 1114914 Furthermore , electroporation in the chick embryo demonstrates that [Msx1] can *induce* expression in the diencephalon neuroepithelium and in the lateral ectoderm . Positive_regulation MSX2 MSX1 9846382 553893 The [Msx2] expression level increased in the blastema at the early bud stage , and expression level *increased* at the late bud stage . Positive_regulation MSX2 TNF 20004646 2199808 In addition , *enhanced* [MSX2] expression in a dose- and time dependent manner . Positive_regulation MSX2 TNF 20004646 2199811 New protein synthesis was dispensable for [MSX2] *induction* by , and the inhibition of NF-kappaB by BAY-11-7082 or by dominant negative IkappaBalpha abolished the TNF-alpha directed induction of MSX2 expression . Positive_regulation MSX2 TNF 20004646 2199817 In conclusion , our study suggests that directly *induces* [MSX2] expression through the NF-kappaB pathway , which in turn induces expression of ALP , a key molecule in mineralization , in VSMCs . Positive_regulation MSX2 TNF 20440096 2282727 Furthermore , *induced* [Msx2] expression , and the knockdown of Msx2 by small interfering RNAs rescued ALP expression , which was inhibited by TNF-alpha . Positive_regulation MSX2 TNF 20440096 2282732 Inhibition of NF-kappaB or JNK activation reduced the inhibitory effect of TNF-alpha on ALP expression , whereas *induced* [Msx2] expression was only suppressed by the inhibition of the NF-kappaB pathway . Positive_regulation MSX2 TNF 21514273 2428770 We found that transiently *increased* [Msx2] expression as well as the expression of canonical Wnt signaling molecules , including Wnt3a , Wnt7a , Wnt7b , Wnt10b , low-density lipoprotein receptor related protein 5 ( LRP5 ) and T-cell factor 1 (TCF1) . Positive_regulation MSX2 TNF 22685265 2633483 Consistent with this , rotenone , an antagonist of mitochondrial complex I , inhibited *induction* of [Msx2] and Nox2 , whereas pyruvate , an anapleurotic mitochondrial metabolic substrate , enhanced induction . Positive_regulation MSX2 TNF 22685265 2633484 Thus , ROS metabolism contributes to *induction* of [Msx2] and procalcific responses in myofibroblasts via TNFR1 . Positive_regulation MSX2 WNT7A 17431004 1748951 *increased* trophectoderm cell proliferation as well as [MSX2] ( msh homeobox 2 ) and MYC ( myelocytomatosis oncogene ) mRNA levels . Positive_regulation MT-CO2 CA12 19181845 2033227 In mice , [CO(2)] responses of the olfactory sensory neurons ( OSNs ) *require* the activity of to catalyze the conversion of CO(2) to bicarbonate and the opening of cGMP-sensitive ion channels . Positive_regulation MT-CO2 CA12 3102472 70119 We conclude that : acetoacetate derived from 2-ketoisocaproate is , like urea , an index of the specific activity of mitochondrial CO2 in liver , activity equalizes the specific activities of the CO2 + bicarbonate system on both sides of the mitochondrial membrane , and a fraction of [ 14C ] formate *derived* [14CO2] appears to be generated in a mitochondrial compartment , in the close vicinity of methylcrotonyl-CoA carboxylase . Positive_regulation MT-CO2 CA12 3115121 77601 We studied the *roles* of gill and erythrocyte in normal [CO2] transfer ( metabolic CO2 elimination ) and in HCO3- excretion during metabolic alkalosis in the resting and swimming dogfish shark , Squalus acanthias . Positive_regulation MT-CO2 CA12 6093699 42147 The strong inhibitor of , acetazolamide , also *inhibited* the [CO2] hydration activity and p-nitrophenyl acetate activity of ubiquitin . Positive_regulation MT-CO2 CA12 6772280 11588 The results suggest the need for reinterpretation of some concepts about the *role* of in [CO2] accumulation in the brain . Positive_regulation MT-CO2 CA12 8002517 283878 *Roles* of intra- and extracellular in alveolar-capillary [CO2] equilibration . Positive_regulation MT-CO2 CA12 9227587 443337 An isolated , perfused tail preparation was used to study the *role* of in [CO2] and NH3 transport across the sarcolemma of white muscle in the rainbow trout . Positive_regulation MT-CO2 IL1B 20397120 2240591 [CO (2)] , but not hypoxia , *induced* a significant reduction in the release of TNF-alpha and IL-8 as well as a significant increase in the release of IL-10 and within the first 4 h after incubation . Positive_regulation MT-CO2 KCNK3 18753386 1956392 channel deficiency *resulted* in a marked reduction of the hypoxia ( by 49 % ) - and [CO2] ( by 68 % ) -evoked increases in the carotid sinus nerve chemoafferent discharge recorded in the in vitro superfused carotid body/carotid sinus nerve preparations . Positive_regulation MT-CO2 TF 6410138 29439 Binding of aluminum to *requires* [CO2] and therefore involves a specific iron site . Positive_regulation MT-CO2 TNF 3426563 81876 *stimulated* [14CO2] production from [ U-14C ] glucose in rat hemidiaphragm preparations , but lactate production and alanine release were not significantly altered . Positive_regulation MT-TS2 CLU 8388743 220248 , ubiquitin , 14K lectin and [RP8] mRNAs are not *induced* in neuronal apoptosis . Positive_regulation MT1IP IL1B 18570937 1930040 RT-PCR analyses revealed [membrane type 1 (MT1)-MMP] mRNA levels , not MMP-2 or tissue inhibitor of MMP (TIMP) , were significantly *increased* by , and Western blot analyses confirmed a significant increase in MT1-MMP protein in response to Est alone . Positive_regulation MT2A EPHB2 23131177 2745289 Representative [MT(2)-selective] ligands also *induced* phosphorylation in both recombinant and native cell lines , and no cross-reactivity to 17 other GPCRs could be detected . Positive_regulation MT2A TNF 7640344 317848 These results suggested that and IFN-beta *activate* [MT-II] gene expression by partially distinct mechanisms . Positive_regulation MT3 IL1B 7932184 275349 mediated [metallothionein] *induction* and cytoprotection against cadmium and cis-diamminedichloroplatinum . Positive_regulation MT3 TNF 12061424 952853 In agreement , [MT-III] and BaP1 did not *induce* the synthesis of by resident peritoneal macrophages in vitro . Positive_regulation MT3 TNF 1570401 187159 Tissue specific *induction* of [metallothionein] synthesis by . Positive_regulation MT3 TNF 8181907 256446 Differential *induction* of [metallothionein] synthesis by interleukin-6 and in rat tissues . Positive_regulation MT4 IL1B 7932184 275348 mediated [metallothionein] *induction* and cytoprotection against cadmium and cis-diamminedichloroplatinum . Positive_regulation MT4 MMP28 10551873 565357 EDTA , 1,10-phenanthroline , reference hydroxamic acid inhibitors , tissue inhibitor of metalloproteinases-1 , and tissue inhibitor of metalloproteinases-2 all potently *blocked* [MT4-MMPCD] enzymatic activity . Positive_regulation MT4 MMP7 10551873 565372 EDTA , 1,10-phenanthroline , reference hydroxamic acid inhibitors , tissue inhibitor of metalloproteinases-1 , and tissue inhibitor of metalloproteinases-2 all potently *blocked* [MT4-MMPCD] enzymatic activity . Positive_regulation MT4 TNF 1570401 187158 Tissue specific *induction* of [metallothionein] synthesis by . Positive_regulation MT4 TNF 8181907 256444 Differential *induction* of [metallothionein] synthesis by interleukin-6 and in rat tissues . Positive_regulation MTA1 IL1B 19840651 2155226 Angelus [MTA] *induced* releasing significantly more than the control . Positive_regulation MTA1 MMP28 21356366 2394743 [MTA] *induced* and interleukin-8 transcription in HCC cells in vitro , accompanied by enhanced proliferation and activation of the transcription factor NF?B . Positive_regulation MTA1 MMP7 21356366 2394759 [MTA] *induced* and interleukin-8 transcription in HCC cells in vitro , accompanied by enhanced proliferation and activation of the transcription factor NF?B . Positive_regulation MTA2 IL1B 16847181 1588145 The messenger RNA expressions of [LARC] ( liver and activation regulated chemokine ) , GMCSF ( granulocyte-macrophage colony stimulating factor ) , epiregulin , ICAM1 ( intercellular adhesion molecule 1 ) , and TGFA ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation MTA2 IL1B 19840651 2155227 Angelus [MTA] *induced* releasing significantly more than the control . Positive_regulation MTA2 MMP28 21356366 2394766 [MTA] *induced* and interleukin-8 transcription in HCC cells in vitro , accompanied by enhanced proliferation and activation of the transcription factor NF?B . Positive_regulation MTA2 MMP7 21356366 2394782 [MTA] *induced* and interleukin-8 transcription in HCC cells in vitro , accompanied by enhanced proliferation and activation of the transcription factor NF?B . Positive_regulation MTA3 IL1B 19840651 2155222 Angelus [MTA] *induced* releasing significantly more than the control . Positive_regulation MTA3 MMP28 21356366 2394666 [MTA] *induced* and interleukin-8 transcription in HCC cells in vitro , accompanied by enhanced proliferation and activation of the transcription factor NF?B . Positive_regulation MTA3 MMP7 21356366 2394682 [MTA] *induced* and interleukin-8 transcription in HCC cells in vitro , accompanied by enhanced proliferation and activation of the transcription factor NF?B . Positive_regulation MTDH CCND1 19304953 2064353 Moreover , we demonstrated that the upregulation of [AEG-1] could reduce the expression of p27 ( Kip1 ) and *induce* the expression of through the AKT/FOXO3a pathway . Positive_regulation MTDH TNF 23889991 2821725 [AEG-1/MTDH/LYRIC] *induction* by HIV-1 and highlights its importance in viral infection , and its incorporation into viral vesicles supports its potential role in active viral replication . Positive_regulation MTDH TNF 24855648 2951130 Co-immunoprecipitation studies demonstrated IL-1ß- or *induced* [AEG-1] interaction with NF-?B p65 subunit . Positive_regulation MTOR ANGPT1 20357108 2231703 The proneurogenic effect of is *mediated* by Tie-2 activation and subsequent [mTOR] ( mammalian target of rapamycin kinase ) mobilization . Positive_regulation MTOR CAPN8 23467348 2750003 In rat hippocampal slices , cortical synaptoneurosomes , and cultured neurons , BDNF induced [mTOR] pathway activation and protein translation were *blocked* by inhibition . Positive_regulation MTOR CCND1 18026138 1894612 Importantly , [mTOR] inhibitors *induced* downregulation of vascular endothelial growth factor A ( VEGF-A ) secretion , and MYCN protein expression in vitro and in vivo . Positive_regulation MTOR EPHB2 15757502 1409727 Activation and phosphorylation of S6K1 ( ribosomal protein S6 kinase 1 ) and phosphorylation of eIF4E ( eukaryotic initiation factor 4E ) -binding protein ( both are mTOR targets ) were also inhibited by MKP3 , suggesting that is also *required* for the activation of [mTOR] signalling . Positive_regulation MTOR EPHB2 17255101 1718052 Similar data indicated that [mTOR] is *regulated* by both phosphatidylinositol 3-kinase/Akt and . Positive_regulation MTOR EPHB2 17671177 1777035 Our results show that S664 TSC2 phosphorylation is a marker for *mediated* ( as opposed to Akt mediated ) [mTOR] activation in TSC and human cancer . Positive_regulation MTOR EPHB2 18826385 1970773 Further , the [mTOR] activated pS6K ( ser240 / 244 ) was *detected* in 86.7 % of ameloblastomas , while was overexpressed in 70.0 % of the cases . Positive_regulation MTOR EPHB2 21107834 2389911 Rapamycin inhibited these phosphorylation events without impacting Akt or Erk activation , even though specific inhibition of Akt or in turn *reduced* the activation of [mTOR] . Positive_regulation MTOR EPHB2 21289294 2419959 Previous studies have shown that , in part , Akt and *promote* [mTORC1] signaling through phosphorylation of a GTPase activator protein (GAP) , referred to as tuberous sclerosis complex 2 (TSC2) , that acts as an upstream inhibitor of mTORC1 . Positive_regulation MTOR EPHB2 21659537 2459604 Our data also reveal striking diversity in the *requirements* for in the control of [mTORC1] between different cell types , pointing to additional signaling connections between phorbol esters and mTORC1 , which do not involve MEK/ERK . Positive_regulation MTOR EPHB2 21889928 2496512 In addition , lonidamine elicits and [Akt/mTOR] pathway *activation* , as indicated by increased ERK , Akt , p70S6K and rpS6 phosphorylation , and these effects are reduced by co-treatment with ATO . Positive_regulation MTOR EPHB2 22265866 2575485 Dorsal hippocampal and [mTOR] *activation* were necessary for P to facilitate memory consolidation , as suggested by the fact that inhibitors of both pathways infused into the dorsal hippocampus immediately after training blocked the P-induced enhancement of object recognition . Positive_regulation MTOR EPHB2 22960230 2684081 Our data suggest that dual [PI3K/mTOR] inhibitors may represent a useful pharmacological tool in the therapy of advanced adrenocortical cancer and that simultaneous inhibition of both and PI3K - mTOR pathways may be *required* to obtain a higher antiproliferative effect in this type of tumor . Positive_regulation MTOR EPHB2 23422279 2744149 Collectively , these data demonstrate for the first time that activation of the dorsal hippocampal mTOR signaling pathway is necessary for E ( 2 ) to enhance object recognition memory consolidation and that E ( 2 ) -induced [mTOR] activation is *dependent* on upstream activation of and PI3K signaling . Positive_regulation MTOR EPHB2 23431403 2744405 We showed that activation of following TCR engagement is *required* for sustained [mTOR complex 1 (mTORC1)] activation . Positive_regulation MTOR EPHB2 23431403 2744417 Absence of kinase suppressor of Ras 1 (KSR1) , a scaffold protein of the ERK signaling pathway , or inhibition of *resulted* in decreased [mTORC1] activity following T cell activation . Positive_regulation MTOR EPHB2 24597762 2933805 Exposure of CGNs to GDF15 markedly induced the phosphorylation of ERK ( extracellular-signal regulated kinase ) , Akt and [mTOR] ( mammalian target of rapamycin ) , but the GDF15 induced IK densities and increased expression of Kv2.1 were *attenuated* only by Akt and mTOR , and not , inhibitors . Positive_regulation MTOR FOXO1 22820375 2640265 activation *resulted* in [mTOR] inhibition by preventing the translocation of mTOR to lysosomal membranes in a glutamine-synthetase dependent manner . Positive_regulation MTOR GPR115 17329974 1707269 [Akt/TSC/mTOR] *activation* by the KSHV : emerging insights into the molecular oncogenesis and treatment of Kaposi 's sarcoma . Positive_regulation MTOR GPR132 17329974 1707258 [Akt/TSC/mTOR] *activation* by the KSHV : emerging insights into the molecular oncogenesis and treatment of Kaposi 's sarcoma . Positive_regulation MTOR GPR87 17329974 1707338 [Akt/TSC/mTOR] *activation* by the KSHV : emerging insights into the molecular oncogenesis and treatment of Kaposi 's sarcoma . Positive_regulation MTOR MAP2K6 18223677 1919067 However , a basal activity of was *required* for the [mTOR] pathway mediated phosphorylation to occur . Positive_regulation MTOR MAP2K6 21659537 2459565 Previous work indicated that [mTORC1] activation by the phorbol ester PMA ( phorbol 12-myristate 13-acetate ) depends upon PKCs and may *involve* . Positive_regulation MTOR MAP2K6 21659537 2459610 Our data also reveal striking diversity in the *requirements* for in the control of [mTORC1] between different cell types , pointing to additional signaling connections between phorbol esters and mTORC1 , which do not involve MEK/ERK . Positive_regulation MTOR MAP2K6 21738705 2452333 Inhibition of with drugs *caused* only modest [mTORC1] inhibition , implying that other unidentified pathways also play major roles . Positive_regulation MTOR MAP2K6 22178087 2543189 We evaluated the effects of RAD001 , [mTOR] *inhibitor* , and U0126 , inhibitor , on cell proliferation and migration of these cells . Positive_regulation MTOR MAP2K6 23852369 2825167 We also used MEL10 cells in which inhibitors do not *inhibit* [MTOR] . Positive_regulation MTOR MAP2K6 23852369 2825174 Our data confirmed that a mere inhibition of the cell cycle was sufficient to cause senescence , providing MTOR was active , and inhibition of partially *inhibited* [MTOR] in a cell-type dependent manner . Positive_regulation MTOR MAP2K6 24442130 2918045 Inhibition of these pathways utilizing PF-04691502 , a PI3K and [mTOR] *inhibitor* , and PD-0325901 , a inhibitor , slowed the tumor growth of PDX models of bladder cancer . Positive_regulation MTOR TLR7 18277459 1872175 In the skin , strategies to inhibit angiogenesis signaling pathways include blockade of COX-2 , [m-TOR] , sonic hedgehog , growth factor receptor activation , and *activation* of . Positive_regulation MTOR TLR7 18924132 1988828 Here we demonstrate that *activate* [mTOR] via phosphoinositide 3-kinase/Akt . Positive_regulation MTOR TNF 12714600 1100553 Phosphorylation of Akt and the [mammalian target of rapamycin] ( but not extracellular regulated kinase or PKCzeta ) in *response* to was inhibited by aspirin treatment . Positive_regulation MTOR TNF 18490760 1917041 In this study , we have explored the involvement of both IKKalpha and IKKbeta in insulin- and *induced* [mTOR] activation . Positive_regulation MTOR TNF 18490760 1917065 In MCF7 cells , does not activate Akt and *requires* IKKbeta to activate [mTOR] . Positive_regulation MTOR TNF 20135642 2235888 also *increased* the Akt and [mTOR] phosphorylation . Positive_regulation MTPAP ARSA 3170419 97616 ( 1 g iv , n = 8 ) , indomethacin ( 2 mg/kg iv , n = 8 ) , and almitrine ( 8 micrograms.kg-1.min-1 iv , n = 8 ) produced a further *increase* in [PAP] at each level of Q . ASA and indomethacin , respectively , increased arterial PO2 from 61 +/- 4 to 70 +/- 3 Torr ( P less than 0.05 ) and from 70 +/- 6 to 86 +/- 6 Torr ( P less than 0.05 ) and decreased intrapulmonary shunt from 61 +/- 5 to 44 +/- 4 % ( P less than 0.05 ) and from 44 +/- 5 to 29 +/- 4 % ( P less than 0.05 ) . Positive_regulation MTPAP EDN2 1348398 182769 S6a , S6b , S6c , ET-1 , , ET-3 , VIC , Lys7-ET-1 , and big ET-1 *increased* [PAP] . Positive_regulation MTTP FOXO1 18497885 1921942 In HepG2 cells , [MTP] expression was *induced* by and inhibited by exposure to insulin . Positive_regulation MTTP FOXO1 18497885 1921943 This effect correlated with the ability of to bind and *stimulate* [MTP] promoter activity . Positive_regulation MTTP TNF 10815618 580206 LPS and [MTP-PE] ( liposome encapsulated N-acetyl-muramyl-L-alanyl-D-isoglutaminyl-L-alanine-2- : [ 1',2'dipalmitoyl -sni-glycero-3- ( hydroxy-phosphoryl-oxyl ) ] etylamide ) *induce* in liver macrophages a synthesis and release of , nitric oxide and prostanoids . Positive_regulation MTTP TNF 10815618 580211 Exogenously added PGE2 inhibits the *activation* of map kinase and release by LPS , but not by [MTP-PE] . Positive_regulation MTTP TNF 10854232 704241 These data indicate that *induction* of the [MTP] by causes a release of cytochrome c , caspase-3 activation with PARP cleavage and DNA fragmentation . Positive_regulation MTTP TNF 7650390 319333 LPS and liposome encapsulated [MTP-PE] *induce* liver macrophages cytotoxicity against tumor target cells and a release of , nitric oxide , and eicosanoids but not a generation of superoxide anions . Positive_regulation MTTP TNF 8299114 248436 We have already reported that [L-MTP-PE] *induced* monocyte mediated tumoricidal activity and up-regulation of the and interleukin-1 (IL-1) in vivo and in vitro . Positive_regulation MTX1 ABCC11 20718756 2330168 We then tested the effect of decreasing the expression of ABCC11 by siRNA and found that decreased expression of enhanced MTA cytotoxicity and *increased* intracellular [MTX] accumulation in MTA-resistant cells . Positive_regulation MTX1 TGM2 16511354 1530705 The *activation* of and ERK1/2 by [MTX] was sup pressed by BAPTA-AM or ROS scavengers . Positive_regulation MTX1 TNF 23159286 2700122 [MTX] alone or VPA alone *induced* a significant increase in tissue CAT and GR with a significant decrease in the tumour volume , tissue MDA , cholesterol and and alleviated the histopathological changes with a significant increase in p53 expression compared to SEC group . Positive_regulation MUC1 CD14 7536782 300306 Our results also suggest that , in [P-PEM] , in contrast to J774.1 cells and T-PEM , neither PKC nor is *involved* in the LPS induced activation and suppression of TNF-alpha gene expression . Positive_regulation MUC1 EPHB2 17237423 1690010 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Positive_regulation MUC1 GPR115 15527548 1330308 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC1 GPR132 15527548 1330297 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC1 GPR87 15527548 1330377 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC1 IL1B 12391274 1007524 These results suggest a role for PGE ( 2 ) in *induced* [mucin] synthesis in NCI-H292 cells . Positive_regulation MUC1 IL1B 12391274 1007542 Furthermore , the addition of PGE ( 2 ) to cells overcame the inhibitory effects of both MAPK inhibitors in *induced* [mucin] production . Positive_regulation MUC1 IL1B 12482999 1024575 *induces* MUC2 gene expression and [mucin] secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation MUC1 IL1B 12482999 1024591 In cultured human airway NCI-H292 epithelial cells , the steady state of the mRNA level of MUC2 gene expression and [mucin] secretion *induced* by were determined by reverse transcriptase-polymerase chain reaction ( RT-PCR ) , enzyme immunoassay , and immunoblot analysis . Positive_regulation MUC1 IL1B 12482999 1024606 PD98059 ( MEK/ERK inhibitor ) suppressed *mediated* MUC2 gene expression and [mucin] secretion , while SB203580 ( p38 inhibitor ) did not . Positive_regulation MUC1 IL1B 12482999 1024621 Ro31-8220 ( PKC inhibitor ) inhibited *mediated* MUC2 gene expression and [mucin] secretion . Positive_regulation MUC1 IL1B 12869928 1112247 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Positive_regulation MUC1 IL1B 12869928 1112277 *upregulates* [mucin] secretion from cultured middle ear epithelial cells in a dose- and time dependent manner . Positive_regulation MUC1 IL1B 15266025 1275882 *induced* [mucin] production in human airway epithelium is mediated by cyclooxygenase-2 , prostaglandin E2 receptors , and cyclic AMP-protein kinase A signaling . Positive_regulation MUC1 IL1B 15668323 1382124 increased the thickness of conducting airways , *enhanced* [mucin] production , and caused lymphocytic aggregates in the airways . Positive_regulation MUC1 IL1B 16467705 1523533 Signaling pathways in *mediated* middle ear [mucin] secretion . Positive_regulation MUC1 IL1B 16467705 1523593 *stimulates* [mucin] secretion from middle ear epithelium and its effects can be reversed by IL-1betara . Positive_regulation MUC1 IL1B 20873538 2326428 These results suggest that may *enhance* [mucin] gene expression in cultured human nasal epithelial cells . Positive_regulation MUC1 LBP 11119527 768404 In the *presence* of a low amount of plasma ( < 1 % ) or of recombinant mouse or human , [PEM] were found to respond to low concentrations of LPS ( < 5 to 10 ng/ml ) in an LBP- and CD14 dependent manner . Positive_regulation MUC1 MMP7 18436821 1900353 and neutrophil elastase *induced* the release of MUC16 but not of [MUC1] or MUC4 . Positive_regulation MUC1 RARB 10024510 590853 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Positive_regulation MUC1 SPHK1 19835973 2203016 *regulates* [mucin] production via ERK phosphorylation . Positive_regulation MUC1 SPHK1 19835973 2203083 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Positive_regulation MUC1 TNF 10030839 591796 *stimulates* [mucin] secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro . Positive_regulation MUC1 TNF 10030839 591811 In this study , we investigated potential signaling pathways mediating *induced* [mucin] secretion using guinea pig tracheal epithelial ( GPTE ) cells in air-liquid interface culture . Positive_regulation MUC1 TNF 10030839 591826 Exogenously applied ( human recombinant ) *stimulated* [mucin] secretion in a concentration dependent manner , with maximal effects at 10 to 15 ng/ml ( 286 to 429 U/ml ) . Positive_regulation MUC1 TNF 10030839 591841 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Positive_regulation MUC1 TNF 10030839 591873 Collectively , the results suggest that *stimulates* secretion of [mucin] by GPTE cells via a mechanism ( s ) dependent on PC-PLC and PKC , and involving activation of NOS , generation of NO , production of cGMP , and activation of PKG . Positive_regulation MUC1 TNF 10950784 723464 *Induction* of [mucin] gene expression in middle ear of rats by : potential cause for mucoid otitis media . Positive_regulation MUC1 TNF 11052828 743490 *stimulates* MUC5AC [mucin] secretion in a dose dependent manner , with 20 ng/ml producing maximal stimulation . Positive_regulation MUC1 TNF 11282555 799143 IL-6 and *stimulated* MUC5AC and MUC5B [mucin] secretion in a time dependent manner , both in pre-confluent and post-confluent cells . Positive_regulation MUC1 TNF 12018326 942424 Recent studies demonstrated that , present in human middle ear effusion , *stimulated* [mucin] production in vitro and up-regulated mucin gene expression in vivo . Positive_regulation MUC1 TNF 12210742 984101 Synergistic *stimulation* of [MUC1] expression in normal breast epithelia and breast cancer cells by interferon-gamma and . Positive_regulation MUC1 TNF 12210742 984104 We demonstrate that [MUC1] expression in T47D breast cancer cells and normal human mammary epithelial cells ( HMEC ) is *enhanced* by in the presence of interferon-gamma (IFN-gamma) . Positive_regulation MUC1 TNF 12210742 984107 Binding of NFkappaB p65 to the [MUC1] kappaB site was *induced* by treatment , as demonstrated by electrophoretic mobility shift assay . Positive_regulation MUC1 TNF 12210742 984108 Collectively , these studies demonstrate synergistic *stimulation* of [MUC1] expression by and IFN-gamma that is mediated by independent actions of NFkappaB p65 and STAT1alpha upon kappaB and STAT sites , respectively , in the MUC1 promoter . Positive_regulation MUC1 TNF 12797589 1098728 *mediated* [MUC1] gene expression may contribute to the pathogenesis of human inflammatory upper airway disorders . Positive_regulation MUC1 TNF 15142990 1279637 Moreover , we established that TNFalpha stimulated MUC1 shedding occurs independently of increased de novo protein synthesis and demonstrated that the *induced* increase in [MUC1] gene expression is mediated through the kappaB site in the MUC1 promoter . Positive_regulation MUC1 TNF 15477874 1380439 Furthermore , IFN-gamma and strongly *induce* [MUC1] expression in both normal prostate epithelia and certain prostate tumor cell lines and may exacerbate pathologies associated with MUC1 positive prostate cancers . Positive_regulation MUC1 TNF 15696080 1372031 Niflumic acid and MSI-2216 reduce *induced* [mucin] expression in human airway mucosa . Positive_regulation MUC1 TNF 15696080 1372048 Unstimulated and *induced* [mucin] expression could be decreased by NFA and MSI-2216 . Positive_regulation MUC1 TNF 16543607 1582115 We demonstrated that cigarette smoke extract (CSE) synergistically increased gene expression and protein production of MUC5AC [mucin] *induced* by LPS or in human airway epithelial NCI-H292 cells . Positive_regulation MUC1 TNF 17575006 1786100 *induces* [MUC1] gene transcription in lung epithelial cells : its signaling pathway and biological implication . Positive_regulation MUC1 TNF 17575006 1786101 The current study was conducted to elucidate the mechanism through which *stimulates* expression of [MUC1] , a membrane tethered mucin . Positive_regulation MUC1 TNF 17575006 1786102 *increased* [MUC1] gene promoter activity in A549 cells transfected with a promoter-luciferase reporter plasmid . Positive_regulation MUC1 TNF 17575006 1786106 Both U0126 , an inhibitor of MEK1/2 , and dominant negative ERK1 prevented *induced* [MUC1] promoter activation , and anti-TNFR1 antibody blocked TNF-alpha stimulated ERK1/2 activation . Positive_regulation MUC1 TNF 17575006 1786108 [MUC1] promoter *activation* by also was blocked by mithramycin A , an inhibitor of Sp1 , as well as either deletion or mutation of a putative Sp1 binding site in the MUC1 promoter located between nucleotides -99 and -90 . Positive_regulation MUC1 TNF 17575006 1786113 We conclude that *induces* [MUC1] gene transcription through a TNFR1 -- > MEK1/2 -- > ERK1 -- > Sp1 pathway . Positive_regulation MUC1 TNF 17717071 1807545 We and others have shown that [MUC1] expression is *activated* by progesterone ( P ) , , and interferon-gamma (IFN-gamma) . Positive_regulation MUC1 TNF 17717071 1807548 PIASy repression of basal , P- , and *stimulated* [MUC1] promoter activity was not dependent on the PIASy sumoylation domain . Positive_regulation MUC1 TNF 18436821 1900342 *induced* the release of [MUC1] , MUC4 , and MUC16 from the HCLE surface . Positive_regulation MUC1 TNF 19053887 2017606 Both LPS and *increased* MUC5AC [mucin] production in vivo and in vitro , respectively , and fudosteine was found to reduce it by partially interfering with the kinase mediated inflammation pathway that activates the MUC5AC gene . Positive_regulation MUC1 TNF 20081068 2226013 We conclude that the RSV induced increase in the levels *upregulates* [MUC1] through its interaction with TNFR , which in turn suppresses further increase in TNFalpha by RSV , thus forming a negative feedback loop in the control of RSV induced inflammation . Positive_regulation MUC1 TNF 20448050 2381089 These results suggest that the up-regulation of [Muc1] during airway PA infection might be crucial for suppressing excessive and prolonged inflammatory responses , and is *induced* mainly by , the key proinflammatory mediator . Positive_regulation MUC1 TNF 22298528 2546358 ( 4 ) the released after treatment with NTHi was *sufficient* to up-regulate [MUC1] , which was completely inhibited by pretreatment with a soluble TNF-a receptor ; Positive_regulation MUC1 TNF 23463646 2895471 Inhibition of *induced* MUC5AC [mucin] gene expression and production by wogonin through the inactivation of NF-?B signaling in airway epithelial cells . Positive_regulation MUC1 TNF 24153432 2889551 Taken together , these results demonstrate that TIIA suppressed LPS induced acute lung inflammation regardless of the presence of Muc1 , and TIIA inhibited LPS- and *induced* [MUC1/Muc1] expression in airway epithelial cells , suggesting that MUC1/Muc1 does not account for the mechanisms of the anti-inflammatory effects of TIIA in the airway . Positive_regulation MUC1 TNF 24348668 2881126 We investigated whether prunetin significantly affects *induced* MUC5AC [mucin] gene expression , production , inhibitory kappa B ( I?B ) degradation and nuclear factor kappa B ( NF-?B ) p65 translocation in human airway epithelial cells . Positive_regulation MUC1 TNF 7842630 286516 *had* little effect on [MUC1] expression , but one or five days exposure to IFN-gamma significantly increased MUC1 expression ( p < 0.01 ) in all cell lines including the two cell lines that initially showed little or no expression . Positive_regulation MUC12 EPHB2 17237423 1690012 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Positive_regulation MUC12 GPR115 15527548 1330401 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC12 GPR132 15527548 1330390 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC12 GPR87 15527548 1330470 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC12 IL1B 12391274 1007525 These results suggest a role for PGE ( 2 ) in *induced* [mucin] synthesis in NCI-H292 cells . Positive_regulation MUC12 IL1B 12391274 1007543 Furthermore , the addition of PGE ( 2 ) to cells overcame the inhibitory effects of both MAPK inhibitors in *induced* [mucin] production . Positive_regulation MUC12 IL1B 12482999 1024576 *induces* MUC2 gene expression and [mucin] secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation MUC12 IL1B 12482999 1024592 In cultured human airway NCI-H292 epithelial cells , the steady state of the mRNA level of MUC2 gene expression and [mucin] secretion *induced* by were determined by reverse transcriptase-polymerase chain reaction ( RT-PCR ) , enzyme immunoassay , and immunoblot analysis . Positive_regulation MUC12 IL1B 12482999 1024607 PD98059 ( MEK/ERK inhibitor ) suppressed *mediated* MUC2 gene expression and [mucin] secretion , while SB203580 ( p38 inhibitor ) did not . Positive_regulation MUC12 IL1B 12482999 1024622 Ro31-8220 ( PKC inhibitor ) inhibited *mediated* MUC2 gene expression and [mucin] secretion . Positive_regulation MUC12 IL1B 12869928 1112248 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Positive_regulation MUC12 IL1B 12869928 1112278 *upregulates* [mucin] secretion from cultured middle ear epithelial cells in a dose- and time dependent manner . Positive_regulation MUC12 IL1B 15266025 1275884 *induced* [mucin] production in human airway epithelium is mediated by cyclooxygenase-2 , prostaglandin E2 receptors , and cyclic AMP-protein kinase A signaling . Positive_regulation MUC12 IL1B 15668323 1382125 increased the thickness of conducting airways , *enhanced* [mucin] production , and caused lymphocytic aggregates in the airways . Positive_regulation MUC12 IL1B 16467705 1523534 Signaling pathways in *mediated* middle ear [mucin] secretion . Positive_regulation MUC12 IL1B 16467705 1523594 *stimulates* [mucin] secretion from middle ear epithelium and its effects can be reversed by IL-1betara . Positive_regulation MUC12 IL1B 20873538 2326429 These results suggest that may *enhance* [mucin] gene expression in cultured human nasal epithelial cells . Positive_regulation MUC12 RARB 10024510 590854 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Positive_regulation MUC12 SPHK1 19835973 2203017 *regulates* [mucin] production via ERK phosphorylation . Positive_regulation MUC12 SPHK1 19835973 2203085 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Positive_regulation MUC12 TNF 10030839 591797 *stimulates* [mucin] secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro . Positive_regulation MUC12 TNF 10030839 591812 In this study , we investigated potential signaling pathways mediating *induced* [mucin] secretion using guinea pig tracheal epithelial ( GPTE ) cells in air-liquid interface culture . Positive_regulation MUC12 TNF 10030839 591827 Exogenously applied ( human recombinant ) *stimulated* [mucin] secretion in a concentration dependent manner , with maximal effects at 10 to 15 ng/ml ( 286 to 429 U/ml ) . Positive_regulation MUC12 TNF 10030839 591842 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Positive_regulation MUC12 TNF 10030839 591874 Collectively , the results suggest that *stimulates* secretion of [mucin] by GPTE cells via a mechanism ( s ) dependent on PC-PLC and PKC , and involving activation of NOS , generation of NO , production of cGMP , and activation of PKG . Positive_regulation MUC12 TNF 10950784 723465 *Induction* of [mucin] gene expression in middle ear of rats by : potential cause for mucoid otitis media . Positive_regulation MUC12 TNF 11052828 743491 *stimulates* MUC5AC [mucin] secretion in a dose dependent manner , with 20 ng/ml producing maximal stimulation . Positive_regulation MUC12 TNF 11282555 799145 IL-6 and *stimulated* MUC5AC and MUC5B [mucin] secretion in a time dependent manner , both in pre-confluent and post-confluent cells . Positive_regulation MUC12 TNF 12018326 942425 Recent studies demonstrated that , present in human middle ear effusion , *stimulated* [mucin] production in vitro and up-regulated mucin gene expression in vivo . Positive_regulation MUC12 TNF 15696080 1372032 Niflumic acid and MSI-2216 reduce *induced* [mucin] expression in human airway mucosa . Positive_regulation MUC12 TNF 15696080 1372049 Unstimulated and *induced* [mucin] expression could be decreased by NFA and MSI-2216 . Positive_regulation MUC12 TNF 16543607 1582117 We demonstrated that cigarette smoke extract (CSE) synergistically increased gene expression and protein production of MUC5AC [mucin] *induced* by LPS or in human airway epithelial NCI-H292 cells . Positive_regulation MUC12 TNF 19053887 2017607 Both LPS and *increased* MUC5AC [mucin] production in vivo and in vitro , respectively , and fudosteine was found to reduce it by partially interfering with the kinase mediated inflammation pathway that activates the MUC5AC gene . Positive_regulation MUC12 TNF 23463646 2895472 Inhibition of *induced* MUC5AC [mucin] gene expression and production by wogonin through the inactivation of NF-?B signaling in airway epithelial cells . Positive_regulation MUC12 TNF 24348668 2881127 We investigated whether prunetin significantly affects *induced* MUC5AC [mucin] gene expression , production , inhibitory kappa B ( I?B ) degradation and nuclear factor kappa B ( NF-?B ) p65 translocation in human airway epithelial cells . Positive_regulation MUC13 EPHB2 17237423 1690014 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Positive_regulation MUC13 GPR115 15527548 1330494 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC13 GPR132 15527548 1330483 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC13 GPR87 15527548 1330563 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC13 IL1B 12391274 1007526 These results suggest a role for PGE ( 2 ) in *induced* [mucin] synthesis in NCI-H292 cells . Positive_regulation MUC13 IL1B 12391274 1007544 Furthermore , the addition of PGE ( 2 ) to cells overcame the inhibitory effects of both MAPK inhibitors in *induced* [mucin] production . Positive_regulation MUC13 IL1B 12482999 1024577 *induces* MUC2 gene expression and [mucin] secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation MUC13 IL1B 12482999 1024593 In cultured human airway NCI-H292 epithelial cells , the steady state of the mRNA level of MUC2 gene expression and [mucin] secretion *induced* by were determined by reverse transcriptase-polymerase chain reaction ( RT-PCR ) , enzyme immunoassay , and immunoblot analysis . Positive_regulation MUC13 IL1B 12482999 1024608 PD98059 ( MEK/ERK inhibitor ) suppressed *mediated* MUC2 gene expression and [mucin] secretion , while SB203580 ( p38 inhibitor ) did not . Positive_regulation MUC13 IL1B 12482999 1024623 Ro31-8220 ( PKC inhibitor ) inhibited *mediated* MUC2 gene expression and [mucin] secretion . Positive_regulation MUC13 IL1B 12869928 1112249 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Positive_regulation MUC13 IL1B 12869928 1112279 *upregulates* [mucin] secretion from cultured middle ear epithelial cells in a dose- and time dependent manner . Positive_regulation MUC13 IL1B 15266025 1275886 *induced* [mucin] production in human airway epithelium is mediated by cyclooxygenase-2 , prostaglandin E2 receptors , and cyclic AMP-protein kinase A signaling . Positive_regulation MUC13 IL1B 15668323 1382126 increased the thickness of conducting airways , *enhanced* [mucin] production , and caused lymphocytic aggregates in the airways . Positive_regulation MUC13 IL1B 16467705 1523535 Signaling pathways in *mediated* middle ear [mucin] secretion . Positive_regulation MUC13 IL1B 16467705 1523595 *stimulates* [mucin] secretion from middle ear epithelium and its effects can be reversed by IL-1betara . Positive_regulation MUC13 IL1B 20873538 2326430 These results suggest that may *enhance* [mucin] gene expression in cultured human nasal epithelial cells . Positive_regulation MUC13 RARB 10024510 590855 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Positive_regulation MUC13 SPHK1 19835973 2203018 *regulates* [mucin] production via ERK phosphorylation . Positive_regulation MUC13 SPHK1 19835973 2203087 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Positive_regulation MUC13 TNF 10030839 591798 *stimulates* [mucin] secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro . Positive_regulation MUC13 TNF 10030839 591813 In this study , we investigated potential signaling pathways mediating *induced* [mucin] secretion using guinea pig tracheal epithelial ( GPTE ) cells in air-liquid interface culture . Positive_regulation MUC13 TNF 10030839 591828 Exogenously applied ( human recombinant ) *stimulated* [mucin] secretion in a concentration dependent manner , with maximal effects at 10 to 15 ng/ml ( 286 to 429 U/ml ) . Positive_regulation MUC13 TNF 10030839 591843 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Positive_regulation MUC13 TNF 10030839 591875 Collectively , the results suggest that *stimulates* secretion of [mucin] by GPTE cells via a mechanism ( s ) dependent on PC-PLC and PKC , and involving activation of NOS , generation of NO , production of cGMP , and activation of PKG . Positive_regulation MUC13 TNF 10950784 723466 *Induction* of [mucin] gene expression in middle ear of rats by : potential cause for mucoid otitis media . Positive_regulation MUC13 TNF 11052828 743492 *stimulates* MUC5AC [mucin] secretion in a dose dependent manner , with 20 ng/ml producing maximal stimulation . Positive_regulation MUC13 TNF 11282555 799147 IL-6 and *stimulated* MUC5AC and MUC5B [mucin] secretion in a time dependent manner , both in pre-confluent and post-confluent cells . Positive_regulation MUC13 TNF 12018326 942426 Recent studies demonstrated that , present in human middle ear effusion , *stimulated* mucin production in vitro and up-regulated [mucin] gene expression in vivo . Positive_regulation MUC13 TNF 15696080 1372033 Niflumic acid and MSI-2216 reduce *induced* [mucin] expression in human airway mucosa . Positive_regulation MUC13 TNF 15696080 1372050 Unstimulated and *induced* [mucin] expression could be decreased by NFA and MSI-2216 . Positive_regulation MUC13 TNF 16543607 1582119 We demonstrated that cigarette smoke extract (CSE) synergistically increased gene expression and protein production of MUC5AC [mucin] *induced* by LPS or in human airway epithelial NCI-H292 cells . Positive_regulation MUC13 TNF 19053887 2017608 Both LPS and *increased* MUC5AC [mucin] production in vivo and in vitro , respectively , and fudosteine was found to reduce it by partially interfering with the kinase mediated inflammation pathway that activates the MUC5AC gene . Positive_regulation MUC13 TNF 23149663 2768994 Using gastrointestinal tissue from Muc1- or Muc13-deficient mice in ex vivo culture , MUC1 small interfering RNA ( siRNA ) silencing in MKN7 gastric epithelial cells , and MUC13 siRNA silencing in LS513 intestinal epithelial cells , we showed that loss of MUC1 increased chemokine secretion , whereas loss of [MUC13] decreased chemokine secretion in *response* to . Positive_regulation MUC13 TNF 23463646 2895473 Inhibition of *induced* MUC5AC [mucin] gene expression and production by wogonin through the inactivation of NF-?B signaling in airway epithelial cells . Positive_regulation MUC13 TNF 24348668 2881128 We investigated whether prunetin significantly affects *induced* MUC5AC [mucin] gene expression , production , inhibitory kappa B ( I?B ) degradation and nuclear factor kappa B ( NF-?B ) p65 translocation in human airway epithelial cells . Positive_regulation MUC15 EPHB2 17237423 1689998 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Positive_regulation MUC15 GPR115 15527548 1329749 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC15 GPR132 15527548 1329738 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC15 GPR87 15527548 1329818 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC15 IL1B 12391274 1007518 These results suggest a role for PGE ( 2 ) in *induced* [mucin] synthesis in NCI-H292 cells . Positive_regulation MUC15 IL1B 12391274 1007536 Furthermore , the addition of PGE ( 2 ) to cells overcame the inhibitory effects of both MAPK inhibitors in *induced* [mucin] production . Positive_regulation MUC15 IL1B 12482999 1024554 *induces* MUC2 gene expression and [mucin] secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation MUC15 IL1B 12482999 1024585 In cultured human airway NCI-H292 epithelial cells , the steady state of the mRNA level of MUC2 gene expression and [mucin] secretion *induced* by were determined by reverse transcriptase-polymerase chain reaction ( RT-PCR ) , enzyme immunoassay , and immunoblot analysis . Positive_regulation MUC15 IL1B 12482999 1024600 PD98059 ( MEK/ERK inhibitor ) suppressed *mediated* MUC2 gene expression and [mucin] secretion , while SB203580 ( p38 inhibitor ) did not . Positive_regulation MUC15 IL1B 12482999 1024615 Ro31-8220 ( PKC inhibitor ) inhibited *mediated* MUC2 gene expression and [mucin] secretion . Positive_regulation MUC15 IL1B 12869928 1112241 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Positive_regulation MUC15 IL1B 12869928 1112271 *upregulates* [mucin] secretion from cultured middle ear epithelial cells in a dose- and time dependent manner . Positive_regulation MUC15 IL1B 15266025 1275870 *induced* [mucin] production in human airway epithelium is mediated by cyclooxygenase-2 , prostaglandin E2 receptors , and cyclic AMP-protein kinase A signaling . Positive_regulation MUC15 IL1B 15668323 1382118 increased the thickness of conducting airways , *enhanced* [mucin] production , and caused lymphocytic aggregates in the airways . Positive_regulation MUC15 IL1B 16467705 1523527 Signaling pathways in *mediated* middle ear [mucin] secretion . Positive_regulation MUC15 IL1B 16467705 1523587 *stimulates* [mucin] secretion from middle ear epithelium and its effects can be reversed by IL-1betara . Positive_regulation MUC15 IL1B 20873538 2326422 These results suggest that may *enhance* [mucin] gene expression in cultured human nasal epithelial cells . Positive_regulation MUC15 RARB 10024510 590847 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Positive_regulation MUC15 SPHK1 19835973 2203010 *regulates* [mucin] production via ERK phosphorylation . Positive_regulation MUC15 SPHK1 19835973 2203071 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Positive_regulation MUC15 TNF 10030839 591790 *stimulates* [mucin] secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro . Positive_regulation MUC15 TNF 10030839 591805 In this study , we investigated potential signaling pathways mediating *induced* [mucin] secretion using guinea pig tracheal epithelial ( GPTE ) cells in air-liquid interface culture . Positive_regulation MUC15 TNF 10030839 591820 Exogenously applied ( human recombinant ) *stimulated* [mucin] secretion in a concentration dependent manner , with maximal effects at 10 to 15 ng/ml ( 286 to 429 U/ml ) . Positive_regulation MUC15 TNF 10030839 591835 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Positive_regulation MUC15 TNF 10030839 591867 Collectively , the results suggest that *stimulates* secretion of [mucin] by GPTE cells via a mechanism ( s ) dependent on PC-PLC and PKC , and involving activation of NOS , generation of NO , production of cGMP , and activation of PKG . Positive_regulation MUC15 TNF 10950784 723458 *Induction* of [mucin] gene expression in middle ear of rats by : potential cause for mucoid otitis media . Positive_regulation MUC15 TNF 11052828 743484 *stimulates* MUC5AC [mucin] secretion in a dose dependent manner , with 20 ng/ml producing maximal stimulation . Positive_regulation MUC15 TNF 11282555 799131 IL-6 and *stimulated* MUC5AC and MUC5B [mucin] secretion in a time dependent manner , both in pre-confluent and post-confluent cells . Positive_regulation MUC15 TNF 12018326 942418 Recent studies demonstrated that , present in human middle ear effusion , *stimulated* [mucin] production in vitro and up-regulated mucin gene expression in vivo . Positive_regulation MUC15 TNF 15696080 1372025 Niflumic acid and MSI-2216 reduce *induced* [mucin] expression in human airway mucosa . Positive_regulation MUC15 TNF 15696080 1372042 Unstimulated and *induced* [mucin] expression could be decreased by NFA and MSI-2216 . Positive_regulation MUC15 TNF 16543607 1582103 We demonstrated that cigarette smoke extract (CSE) synergistically increased gene expression and protein production of MUC5AC [mucin] *induced* by LPS or in human airway epithelial NCI-H292 cells . Positive_regulation MUC15 TNF 19053887 2017600 Both LPS and *increased* MUC5AC [mucin] production in vivo and in vitro , respectively , and fudosteine was found to reduce it by partially interfering with the kinase mediated inflammation pathway that activates the MUC5AC gene . Positive_regulation MUC15 TNF 23463646 2895465 Inhibition of *induced* MUC5AC [mucin] gene expression and production by wogonin through the inactivation of NF-?B signaling in airway epithelial cells . Positive_regulation MUC15 TNF 24348668 2881120 We investigated whether prunetin significantly affects *induced* MUC5AC [mucin] gene expression , production , inhibitory kappa B ( I?B ) degradation and nuclear factor kappa B ( NF-?B ) p65 translocation in human airway epithelial cells . Positive_regulation MUC16 ACACA 17600317 1804680 In explanted human airway mucosa alone significantly *increased* [mucin] expression ( P < 0.05 ) . Positive_regulation MUC16 ACACA 17600317 1804710 In Calu-3 cells alone *had* no significant effect on [mucin] expression ( P > 0.05 ) . Positive_regulation MUC16 ACACA 17600317 1804755 alone may *increase* [mucin] expression in noninfected mucosa , but it decreased bacteria induced mucin expression . Positive_regulation MUC16 ADAM17 12972643 1143515 We hypothesized that *increases* the shedding of TGF-alpha , resulting in EGFR phosphorylation and inducing [mucin] production in human airway epithelial ( NCI-H292 ) cells . Positive_regulation MUC16 AHR 20709182 2381211 These results suggest that the *induced* increase of [mucin] production is partially mediated by ROS generation . Positive_regulation MUC16 AHR 21646808 2442024 activation *mediates* gene alteration , cell-cell adhesion interaction , cytokine expression , and [mucin] production , which are involved in the induction of cancer or inflammation . Positive_regulation MUC16 AHR 21646808 2442039 We have reported that human bronchial epithelial cells express AhR , and activation *induces* [mucin] production through reactive oxygen species . Positive_regulation MUC16 AHR 22500183 2583857 We have previously reported that human bronchial epithelial cells express , and AhR activation *induces* [mucin] production through reactive oxygen species . Positive_regulation MUC16 APOB 15485666 1320686 Nontypeable Haemophilus influenzae P6 *induces* MUC5AC [mucin] transcription via TLR2-TAK1 dependent p38 MAPK-AP1 and IKKbeta-IkappaBalpha-NF-kappaB signaling pathways . Positive_regulation MUC16 AQP5 21455588 2417347 expression *increases* [mucin] production in lung adenocarcinoma . Positive_regulation MUC16 AQP5 21455588 2417377 We tested MUC5AC and MUC5B [mucin] production *induced* by expression in lung adenocarcinoma metastasis . Positive_regulation MUC16 AQP5 21455588 2417394 Our results also showed that expression *increases* MUC5AC and MUC5B [mucin] production and that this may be partly through the EGFR signaling pathway . Positive_regulation MUC16 AQP5 21455588 2417410 In brief , our results provide evidence that [mucin] production *induced* by expression may play important roles in enhanced metastasis potential in lung adenocarcinoma . Positive_regulation MUC16 AREG 15696081 1372058 FcepsilonRI mediated production by human mast cells *increases* [mucin] gene expression in epithelial cells . Positive_regulation MUC16 AREG 16543607 1582141 CSE also enhanced expression and production of MUC5AC [mucin] *induced* by epidermal growth factor receptor (EGFR) ligands TGF-alpha and , as well as LPS- and TNF-alpha- induced expression and/or release of TGF-alpha and amphiregulin . Positive_regulation MUC16 ARSH 10702361 672667 Residual oil fly *induces* cytotoxicity and [mucin] secretion by guinea pig tracheal epithelial cells via an oxidant mediated mechanism . Positive_regulation MUC16 BCL2 16581697 1543761 Novel pharmacotherapeutic targets are being investigated , including inhibitors of nerve activity ( e.g. large conductance calcium activated potassium , BKCa , channel activators ) , tachykinin receptor antagonists , epoxygenase inducers ( e.g. benzafibrate ) , inhibitors of mucin exocytosis ( e.g. anti myristoylated alanine-rich C kinase substrate ( MARCKS ) , peptide and Munc-18B blockers ) , inhibitors of mucin synthesis and goblet cell hyperplasia ( e.g. epidermal growth factor ( EGF ) , receptor tyrosine kinase inhibitors , p38 mitogen activated protein ( MAP ) , kinase inhibitors , MAP kinase kinase/extracellular signal regulated kinase ( MEK/ERK ) , inhibitors , human calcium activated chloride ( hCACL2 ) , channel blockers and retinoic acid receptor-a antagonists ) , inducers of goblet cell apoptosis ( e.g . Bax inducers or inhibitors ) , and purinoceptor P(2Y2) antagonists to *inhibit* [mucin] secretion or P(2Y2) agonists to hydrate secretions . Positive_regulation MUC16 C1orf228 24895124 2951916 *stimulated* Muc2 gene expression and [mucin] production in LS174T cells , which were abolished by inhibition of EGFR kinase activity , down-regulation of EGFR expression by EGFR siRNA transfection , or suppression of Akt activation . Positive_regulation MUC16 C3 17400733 1748596 To determine if the receptor with its ligand *regulates* airway epithelial [mucin] production . Positive_regulation MUC16 CA2 1340298 209257 PKC inhibitors , H7 and staurosporine inhibited E. histolytica ( 37 and 75 % ) and PMA ( 46 and 100 % ) -induced mucin secretion , whereas in *response* to ionophore [mucin] secretion was augmented ( 56 and 17 % ) . Positive_regulation MUC16 CA2 16439799 1561249 The induction of [mucin] by flagellin in human lung epithelial cells ( NCIH292 ) is *dependent* on asialoGM1 ligation , ATP receptor signaling , mobilization , and Erk1/2 activation . Positive_regulation MUC16 CA2 172149 2555 Noradrenalin and adrenalin induced only a slow [mucin] secretion and , for this secretory process , exogenous is also *required* . Positive_regulation MUC16 CA2 3756215 63785 High submucosal ( 3.6-18 mM ) significantly *increased* the secretion of a common high molecular weight fibrillar [mucin] ( approx. Mr is greater than 2.10 ( 6 ) ) and also elicited the secretion of an additional low molecular weight component ( approx. Mr 325,000 ) . Positive_regulation MUC16 CA2 3756215 63800 Low luminal ( 0.018 mM ) also significantly *increased* the secretion of a common high molecular weight gelatinous [mucin] ( approx. Mr is greater than 2.10 ( 6 ) ) and elicited the secretion of an additional low molecular weight component ( approx. Mr 46,200 ) . Positive_regulation MUC16 CA2 9032127 414783 We conclude that [mucin] release by ATP does not *require* an increase in the intracellular level but involves the activation of protein kinase C . Positive_regulation MUC16 CALM3 16467705 1523547 Epithelial cultures exposed to IL-1beta demonstrate an increase in [mucin] secretion that is *blocked* by specific inhibitors of PC-PLC , PKC , and NOS , but not by inhibitors of . Positive_regulation MUC16 CAMP 24291709 2893974 We showed in vitro that *induces* MUC5AC [mucin] production by airway epithelial NCI-H292 cells in the absence and presence of cigarette smoke extract , with TNF-a converting enzyme ( TACE ) -EGFR-ERK1/2 pathway and IL-8 required for the induction . Positive_regulation MUC16 CCDC88A 8655762 364697 We isolated sublingual mucous acini from five-month-old and 24-month-old rats and compared the concentration responses for [mucin] secretion *induced* by VIP and the muscarinic agonist , . Positive_regulation MUC16 CCK 9178925 434315 Carbachol , secretin , and prostaglandin E2 ( PGE2 ) strongly *stimulated* [mucin] secretion , and gastrin I weakly did . Positive_regulation MUC16 CCL2 21097527 2383280 In the present study we used differentiated primary cultures of normal human bronchial epithelial ( NHBE ) cells to test whether through its receptor CCR2 *induces* [mucin] upregulation . Positive_regulation MUC16 CCL20 21300824 2398523 In this study , we show that binding of , a G protein coupled receptor (GPCR) ligand that is upregulated in the airways of subjects with obstructive airway diseases , to its unique GPCR CCR6 *induces* MUC5AC [mucin] production in human airway epithelial ( NCI-H292 ) cells via metalloprotease TNF-a converting enzyme ( TACE ) -dependent EGFR activation . Positive_regulation MUC16 CCR6 21300824 2398524 In this study , we show that binding of CCL20 , a G protein coupled receptor (GPCR) ligand that is upregulated in the airways of subjects with obstructive airway diseases , to its unique GPCR *induces* MUC5AC [mucin] production in human airway epithelial ( NCI-H292 ) cells via metalloprotease TNF-a converting enzyme ( TACE ) -dependent EGFR activation . Positive_regulation MUC16 CDC73 1540379 180748 Both NDGA and BPB blocked *stimulated* [mucin] release in a concentration dependent manner . Positive_regulation MUC16 CDC73 3653044 78292 These results are consistent with the hypothesis that *stimulates* secretion of [mucin] by activating biosynthesis of lipoxygenase products ( e.g. , peptidyl leukotrienes ) within epithelial cells of the respiratory mucosa . Positive_regulation MUC16 CDC73 8049080 267198 This study assessed the role of protein kinase C ( PKC ) in *induced* [mucin] release from primary cultures of feline tracheal epithelial cells ( FTEC ) . Positive_regulation MUC16 CDC73 8049080 267273 Coincubation of FTEC with PAF ( 5 microM ) and pharmacologic PKC inhibitors , sphingosine , H7 , or calphostin C , inhibited *induced* [mucin] secretion at 30 min . Positive_regulation MUC16 CDC73 8049080 267348 Determination of the specific PKC isozyme ( s ) involved in *induced* [mucin] release was performed by immunoblot analysis of the subcellular fractions using a battery of antibodies against various PKC isozymes ( anti-PKC alpha , beta , delta , gamma , epsilon , and zeta ) . Positive_regulation MUC16 CDC73 9552223 492384 In HT-29 cells , MMS-68 plus leukotriene C4 ( LTC4 ) induced a 50 % increase in mucin release over either secretagogue alone , and MMS-68 plus markedly *enhanced* [mucin] release by eightfold over either secretagogue . Positive_regulation MUC16 CDC73 9620929 510661 In this study , we examined the hypothesis that *induces* goblet cell hyperplasia and [mucin] gene expression . Positive_regulation MUC16 CDC73 9620929 510736 In rat tracheas studied by in situ hybridization , *induced* [mucin] MUC5 gene expression in epithelial cells that stained for mucosubstances . Positive_regulation MUC16 CDH1 16055478 1473761 *promotes* EGFR mediated cell differentiation and MUC5AC [mucin] expression in cultured human airway epithelial cells . Positive_regulation MUC16 CDH1 16055478 1473810 E-cadherin blockade also increased EGFR dependent cell proliferation and TGF-alpha induced EGFR tyrosine phosphorylation in dense cultures of NCI-H292 cells , suggesting that *promotes* EGFR dependent [mucin] production and inhibits EGFR dependent cell proliferation via modulation of EGFR phosphotyrosine levels . Positive_regulation MUC16 CDH1 21512244 2428660 However , the *role* of in modulating [mucin] production is not completely understood . Positive_regulation MUC16 CDX2 14525978 1174402 In conclusion , this work demonstrates that *activates* the expression of MUC2 [mucin] gene in gastric cells , inducing an intestinal transdifferentiation phenotype that parallels what is observed both in intestinal metaplasia and some gastric carcinomas . Positive_regulation MUC16 CFTR 10488073 645108 In submandibular acinar cells , MPB compounds slightly stimulate *mediated* submandibular [mucin] secretion without changing intracellular cAMP and ATP levels . Positive_regulation MUC16 CLCA1 12568493 1029467 We show here that expression in NCI-H292 cells specifically *induces* soluble gel forming [mucin] production . Positive_regulation MUC16 CLCA1 17426222 1723920 In this study , we investigated the *role* of the putative calcium activated and its blocker , niflumic acid , in cigarette smoke induced [mucin] synthesis both in vivo and in vitro . Positive_regulation MUC16 CLCA1 24021422 2882404 Results showed that overexpression *caused* high cell proliferation and [mucin] expression , whereas the hCLCA1 DNA vaccine could effectively reverse these abnormal effects . Positive_regulation MUC16 CRH 8944704 400234 We conclude that released during immobilization stress increases colonic transit via a neuronal pathway and *stimulates* colonic [mucin] secretion via activation of neurons and mast cells . Positive_regulation MUC16 CRH 9629290 512243 Our results indicate that released during immobilization stress increases colonic transit via a neuronal pathway and *stimulates* colonic [mucin] release via activation of neurons and colonic mast cells . Positive_regulation MUC16 CSE 16543607 1582106 We demonstrated that synergistically *increased* gene expression and protein production of MUC5AC [mucin] induced by LPS or TNF-alpha in human airway epithelial NCI-H292 cells . Positive_regulation MUC16 CSE 16543607 1582139 also *enhanced* expression and production of MUC5AC [mucin] induced by epidermal growth factor receptor (EGFR) ligands TGF-alpha and amphiregulin , as well as LPS- and TNF-alpha- induced expression and/or release of TGF-alpha and amphiregulin . Positive_regulation MUC16 CSN2 12181163 977463 The hydrolysate *induced* [mucin] secretion is triggered by a neural pathway and mediated by opioid receptor activation . Positive_regulation MUC16 CSN3 12181163 977462 The hydrolysate *induced* [mucin] secretion is triggered by a neural pathway and mediated by opioid receptor activation . Positive_regulation MUC16 CTR9 1540379 180749 Both NDGA and BPB blocked *stimulated* [mucin] release in a concentration dependent manner . Positive_regulation MUC16 CTR9 3653044 78293 These results are consistent with the hypothesis that *stimulates* secretion of [mucin] by activating biosynthesis of lipoxygenase products ( e.g. , peptidyl leukotrienes ) within epithelial cells of the respiratory mucosa . Positive_regulation MUC16 CTR9 8049080 267199 This study assessed the role of protein kinase C ( PKC ) in *induced* [mucin] release from primary cultures of feline tracheal epithelial cells ( FTEC ) . Positive_regulation MUC16 CTR9 8049080 267274 Coincubation of FTEC with PAF ( 5 microM ) and pharmacologic PKC inhibitors , sphingosine , H7 , or calphostin C , inhibited *induced* [mucin] secretion at 30 min . Positive_regulation MUC16 CTR9 8049080 267349 Determination of the specific PKC isozyme ( s ) involved in *induced* [mucin] release was performed by immunoblot analysis of the subcellular fractions using a battery of antibodies against various PKC isozymes ( anti-PKC alpha , beta , delta , gamma , epsilon , and zeta ) . Positive_regulation MUC16 CTR9 9552223 492385 In HT-29 cells , MMS-68 plus leukotriene C4 ( LTC4 ) induced a 50 % increase in [mucin] release over either secretagogue alone , and MMS-68 plus markedly *enhanced* mucin release by eightfold over either secretagogue . Positive_regulation MUC16 CTR9 9620929 510662 In this study , we examined the hypothesis that *induces* goblet cell hyperplasia and [mucin] gene expression . Positive_regulation MUC16 CTR9 9620929 510737 In rat tracheas studied by in situ hybridization , *induced* [mucin] MUC5 gene expression in epithelial cells that stained for mucosubstances . Positive_regulation MUC16 CTSL 15521635 1329090 The ability of F. hepatica ES to degrade [mucin] in the *presence* or absence of active suggests that cathepsin L is not essential for mucin degradation . Positive_regulation MUC16 DUSP1 18782768 1980478 *regulates* the induction of MUC5AC [mucin] by Streptococcus pneumoniae pneumolysin by inhibiting the PAK4-JNK signaling pathway . Positive_regulation MUC16 EGF 10954043 724495 The *induced* increase in [ 3H ] -labeled [mucin] in the full-thickness mucosa was not suppressed by either NG-nitro-L-arginine ( 10 ( -5 ) M ) or 2- ( 4-carboxyphenyl ) -4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide ( 10 ( -5 ) M ) . Positive_regulation MUC16 EGF 11023038 738211 Thus , the present experiments suggests that GGA , as well as , *stimulates* [mucin] synthesis at least in part through an NO-dependent pathway , leading to an increase in the integrity of the gastric mucosa . Positive_regulation MUC16 EGF 11769575 890420 The production of [mucin] was *regulated* by in vitro . Positive_regulation MUC16 EGF 11769575 890450 The [mucin] secretion was also *stimulated* by either or Pseudomonas extracts but more strong secretion of mucin and MUC5AC gene expression in the rat tracheal epithelial cell was done by Pseudomonas extracts . Positive_regulation MUC16 EGF 16009452 1453017 In addition , *regulates* [mucin] secretion in normal airway goblet cells . Positive_regulation MUC16 EGF 19288529 2141761 Genistein and curcumin suppress *induced* MUC5AC [mucin] production and gene expression from human airway epithelial cells . Positive_regulation MUC16 EGF 19288529 2141777 This study investigated whether genistein and curcumin affect *induced* MUC5AC [mucin] production and gene expression from human airway epithelial cells . Positive_regulation MUC16 EGF 21146382 2437428 Glycyrrhizin and carbenoxolone were found to *inhibit* the production of MUC5AC [mucin] protein induced by EGF or PMA , and both compounds also inhibited the expression of MUC5AC mucin gene induced by or PMA . Positive_regulation MUC16 EGF 21442679 2421916 suppress and phorbol ester *induced* MUC5AC [mucin] production and gene expression from human airway epithelial cells . Positive_regulation MUC16 EGF 21442679 2421950 Oleanolic acid and ursolic acid were found to *inhibit* the production of MUC5AC [mucin] protein induced by EGF and PMA , and both compounds also inhibited the expression of MUC5AC mucin gene induced by and PMA . Positive_regulation MUC16 EGF 22388989 2705765 Phorbol ester or *induced* MUC5AC [mucin] gene expression and production from airway epithelial cells are inhibited by apigenin and wogonin . Positive_regulation MUC16 EGF 3266224 103882 The [CA-125] secretion of OMC-4 was not *stimulated* by . Positive_regulation MUC16 EGF 9419754 291231 *enhances* secretion of the ovarian tumor associated cancer antigen [CA125] from the human amnion WISH cell line . Positive_regulation MUC16 EGF 9419754 291233 We investigated quantitatively and immunohistochemically *stimulated* [CA125] release from WISH cells and the effect of EGF on CA125 phosphorylation . Positive_regulation MUC16 EGF 9419754 291235 *increased* the secreted [CA125] levels by 50 % in day-4 cells but had no effect on day-8 cells . Positive_regulation MUC16 EGF 9419754 291236 [CA125] from WISH cells was phosphorylated , and further *enhanced* this phosphorylation . Positive_regulation MUC16 EGFR 11133503 769203 These findings indicate that signaling is *involved* in IL-13 induced [mucin] production . Positive_regulation MUC16 EGFR 15121636 1266513 We hypothesize that TNF-alpha converting enzyme (TACE) is activated by cigarette smoke , resulting in increased shedding of EGFR proligand , leading to phosphorylation and [mucin] *induction* in human airway epithelial ( NCI-H292 ) cells . Positive_regulation MUC16 EGFR 15266025 1275912 However , neither inhibition of activation with the tyrosine kinase inhibitor 4- ( 3-chloroanilino ) -6,7-dimethoxyquinazoline HCl ( AG-1478 ) or EGFR blocking antibody nor inhibition of extracellular signal regulated kinase/P-38 mitogen activated protein kinases with specific inhibitors *blocked* IL-1beta stimulation of MUC5AC [mucin] production . Positive_regulation MUC16 EGFR 15516478 1328571 *Roles* of activation in epithelial cell repair and [mucin] production in airway epithelium . Positive_regulation MUC16 EGFR 16055478 1473777 In previous work , we showed that activation *causes* [mucin] expression in airway epithelium in vivo and in human NCI-H292 airway epithelial cells and normal human bronchial epithelial ( NHBE ) cells in vitro . Positive_regulation MUC16 EGFR 16055478 1473792 In support of this hypothesis , in dense cultures of NCI-H292 cells and in NHBE cells at air-liquid interface , blockade of E-cadherin mediated cell-cell contacts decreased *dependent* [mucin] production . Positive_regulation MUC16 EGFR 16055478 1473811 E-cadherin blockade also increased EGFR dependent cell proliferation and TGF-alpha induced EGFR tyrosine phosphorylation in dense cultures of NCI-H292 cells , suggesting that E-cadherin promotes *dependent* [mucin] production and inhibits EGFR dependent cell proliferation via modulation of EGFR phosphotyrosine levels . Positive_regulation MUC16 EGFR 16543607 1582140 CSE also enhanced expression and production of MUC5AC [mucin] *induced* by ligands TGF-alpha and amphiregulin , as well as LPS- and TNF-alpha- induced expression and/or release of TGF-alpha and amphiregulin . Positive_regulation MUC16 EGFR 16543607 1582181 Furthermore , ( 4- [ ( 3-bromophenyl ) amino ] -6,7-diaminoquinazoline ) , a potent inhibitor of , *blocked* synergistic induction of MUC5AC [mucin] . Positive_regulation MUC16 EGFR 16980555 1682712 However , there was constitutive release of TGF-alpha from normal human bronchial epithelial cells , and inhibition of TGF-alpha or *reduced* both constitutive and IL-13 induced [mucin] production . Positive_regulation MUC16 EGFR 17218812 1682109 activation *causes* [mucin] production and inhibition prevents mucin production by multiple stimuli . Positive_regulation MUC16 EGFR 17426222 1723950 Both in vivo and in vitro , the induction of MUC5AC and [mucin] synthesis were *inhibited* by niflumic acid , and/or a selective tyrosine kinase inhibitor , AG-1478 . Positive_regulation MUC16 EGFR 19429776 2096299 Fibrinogen binding to ICAM-1 promotes *dependent* [mucin] production in human airway epithelial cells . Positive_regulation MUC16 EGFR 19429776 2096317 Because expression of ICAM-1 and of the ICAM-1 ligand fibrinogen is increased in the airways of subjects with mucous hypersecretory diseases , we hypothesized that fibrinogen binding to ICAM-1 could increase *dependent* [mucin] production in human airway ( NCI-H292 ) epithelial cells . Positive_regulation MUC16 EGFR 20724237 2317925 It is known that activation of and its downstream signaling cascade are *involved* in [mucin] production . Positive_regulation MUC16 EGFR 20724237 2317955 In this investigation , we demonstrate that NE-induced [mucin] production *requires* reactive oxygen species ( ROS ) production , which activates TACE , resulting in TGF-a shedding , and phosphorylation in NCI-H292 epithelial cells . Positive_regulation MUC16 EGFR 20962773 2389506 Reactive oxygen species mediate inflammatory cytokine release and *dependent* [mucin] secretion in airway epithelial cells exposed to Pseudomonas pyocyanin . Positive_regulation MUC16 EGFR 21300824 2398504 CCL20/CCR6 feedback exaggerates *dependent* MUC5AC [mucin] production in human airway epithelial ( NCI-H292 ) cells . Positive_regulation MUC16 EGFR 21868713 2546691 signaling *mediates* vesicant induced airway epithelial secretion of interleukin-6 and production of [mucin] . Positive_regulation MUC16 EHMT1 17652153 1776084 Furthermore , vasoactive intestinal polypeptide modulates the actions of GLP-2 in models of intestinal inflammation , while keratinocyte growth factor is required for *induced* colonic mucosal growth and [mucin] expression . Positive_regulation MUC16 ELANE 12169572 973848 *induces* [mucin] production by ligand dependent epidermal growth factor receptor activation . Positive_regulation MUC16 ELANE 16148149 1455117 *induces* MUC5AC [mucin] production in human airway epithelial cells via a cascade involving protein kinase C , reactive oxygen species , and TNF-alpha converting enzyme . Positive_regulation MUC16 ELANE 16491824 1496188 *causes* MUC5AC [mucin] synthesis via EGF receptor , ERK and NF-kB pathways in A549 cells . Positive_regulation MUC16 ELANE 17395013 1721118 , a potent neutrophil inflammatory mediator , *increases* MUC5AC [mucin] gene expression through undefined pathways involving reactive oxygen species . Positive_regulation MUC16 ELANE 18436821 1900344 Matrix metalloproteinase-7 and *induced* the release of [MUC16] but not of MUC1 or MUC4 . Positive_regulation MUC16 ELANE 19394453 2089425 L-carbocisteine reduces *induced* [mucin] production . Positive_regulation MUC16 ELANE 22133475 2536124 PAS staining showed that SPINK5 slightly decreased the [mucin] production *induced* by in A549 cells . Positive_regulation MUC16 ELANE 22144578 2542505 Both VAMP8 short interfering RNAs ( siRNAs ) and short hairpin RNAs ( shRNAs ) reduced [mucin] secretion *induced* by PAR agonists , and ATP in two airway epithelial cell culture models . Positive_regulation MUC16 EPHB2 17237423 1690000 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Positive_regulation MUC16 ERN1 23168839 2769019 The ER stress transducer is *required* for airway epithelial [mucin] production . Positive_regulation MUC16 ERN1 23168839 2769037 *dependent* [mucin] production is mediated , at least in part , by activation of the transcription factor X-box binding protein-1 (XBP-1) and the resulting XBP-1 dependent transcription of anterior gradient homolog 2 , a gene implicated in airway and intestinal epithelial mucin production . Positive_regulation MUC16 F10 17082493 1675679 In vitro investigations using human mucus producing NCI-H292 cells indicated that exogenous *enhanced* [mucin] production in a dose dependent manner . Positive_regulation MUC16 F2RL1 14500256 1218224 These results indicate that HAT enhances mucin gene expression through an AR-EGFR pathway , and is not sufficient for or does not directly *cause* HAT induced [mucin] gene expression . Positive_regulation MUC16 F2RL1 18028876 1835950 activation *increases* human intestinal [mucin] secretion through EGFR transactivation . Positive_regulation MUC16 F2RL1 18028876 1835994 Inhibitors of MAPK activation ( PD98059 ) and EGFR tyrosine kinase activity ( AG1478 ) abrogated *induced* ERK1/2 and EGFR tyrosine phosphorylation , respectively , and subsequent [mucin] secretion . Positive_regulation MUC16 F2RL1 18028876 1836012 Our results show that the activation of expressed by human intestinal epithelial cells *enhances* [mucin] secretion , a component of the intestinal innate defence , via a pathway involving EGFR transactivation . Positive_regulation MUC16 FGB 19429776 2096318 Because expression of ICAM-1 and of the ICAM-1 ligand fibrinogen is increased in the airways of subjects with mucous hypersecretory diseases , we hypothesized that binding to ICAM-1 could *increase* EGFR dependent [mucin] production in human airway ( NCI-H292 ) epithelial cells . Positive_regulation MUC16 FGF7 17652153 1776085 Furthermore , vasoactive intestinal polypeptide modulates the actions of GLP-2 in models of intestinal inflammation , while is *required* for GLP-2 induced colonic mucosal growth and [mucin] expression . Positive_regulation MUC16 FUT1 19995145 2174496 EBC analysis suggests that *causes* an increase in pH and [mucin] in both groups , but EBC volume and histamine only increased in the BHR ( + ) group . Positive_regulation MUC16 GAB2 22859374 2692204 Docking protein *regulates* [mucin] expression and goblet cell hyperplasia through TYK2/STAT6 pathway . Positive_regulation MUC16 GAD1 20448051 2381107 The nicotine induced increase in and GABA(A) receptor mRNA *resulted* in increased GABA induced currents and increased expression of [mucin] . Positive_regulation MUC16 GALNT7 10544240 564062 showed no activity with a large panel of non glycosylated peptides , but was selectively *activated* by partial GalNAc glycosylation of peptide substrates derived from the tandem repeats of human MUC2 and rat submaxillary gland [mucin] . Positive_regulation MUC16 GAPDH 18790050 1993213 Lactobacillus plantarum LA 318 is a potential probiotic strain isolated from normal human intestinal tissue that shows high adhesion to human colonic [mucin] *mediated* by the bacterial cell surface ( GAPDH ) . Positive_regulation MUC16 GAST 1333428 204372 A 7.8 % +/- 1.7 % increase in mucin above basal levels after 24 hours was observed with a solid-phase immunoassay in control wells , whereas histamine , , and carbamylcholine *increased* total [mucin] by 14 % +/- 0.7 % , 17 % +/- 4.3 % , and 20.4 % +/- 4 % , respectively ( all P < 0.01 ) , and PGE2 had no significant effect . Positive_regulation MUC16 GAST 1333428 204387 The acid secretagogues histamine , , and carbamylcholine *stimulated* [mucin] synthesis and PC release . Positive_regulation MUC16 GATA5 14986113 1295046 The aim of the current study is to elucidate whether or not expression of [mucin] genes is *regulated* by . Positive_regulation MUC16 GGA1 11023038 738210 Thus , the present experiments suggests that , as well as EGF , *stimulates* [mucin] synthesis at least in part through an NO-dependent pathway , leading to an increase in the integrity of the gastric mucosa . Positive_regulation MUC16 GGA2 11023038 738208 Thus , the present experiments suggests that , as well as EGF , *stimulates* [mucin] synthesis at least in part through an NO-dependent pathway , leading to an increase in the integrity of the gastric mucosa . Positive_regulation MUC16 GGA3 11023038 738209 Thus , the present experiments suggests that , as well as EGF , *stimulates* [mucin] synthesis at least in part through an NO-dependent pathway , leading to an increase in the integrity of the gastric mucosa . Positive_regulation MUC16 GJA1 18723040 1975034 We show that [MUC] *induces* cross linking of the gap junction protein and that this is likely to be responsible for the induced inhibition of GJIC , as well as the loss of connexin43 observed in Western blots . Positive_regulation MUC16 GLA 19415319 2100908 The decrease in [mucin] production observed on the conjunctival epithelium was partially *prevented* by EPA + DHA supplementation after 2 days of scopolamine treatment , as well as by GLA and + EPA + DHA diets after 10 days of treatment . Positive_regulation MUC16 GPR1 15527548 1329872 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR101 15527548 1329828 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR107 15527548 1329833 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR108 15527548 1329832 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR110 15527548 1329838 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR111 15527548 1329839 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR112 15527548 1329840 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR113 15527548 1329837 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR114 15527548 1329841 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR115 15527548 1329842 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR116 15527548 1329843 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR119 15527548 1329844 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR12 15527548 1329873 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR123 15527548 1329825 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR124 15527548 1329834 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR125 15527548 1329826 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR126 15527548 1329827 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR128 15527548 1329845 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR132 15527548 1329831 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR133 15527548 1329846 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR135 15527548 1329847 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR137 15527548 1329865 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR139 15527548 1329848 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR141 15527548 1329849 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR142 15527548 1329850 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR143 15527548 1329851 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR144 15527548 1329836 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR146 15527548 1329853 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR148 15527548 1329857 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR149 15527548 1329859 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR15 15527548 1329874 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR150 15527548 1329860 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR151 15527548 1329858 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR152 15527548 1329856 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR153 15527548 1329855 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR155 15527548 1329854 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR156 15527548 1329852 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR157 15527548 1329861 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR158 15527548 1329862 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR160 15527548 1329863 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR161 15527548 1329864 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR162 15527548 1329829 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR17 15527548 1329875 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR171 15527548 1329867 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR173 15527548 1329835 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR174 15527548 1329868 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR176 15527548 1329871 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR179 15527548 1329870 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR18 15527548 1329876 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR180 15527548 1329866 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR182 15527548 1329823 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR183 15527548 1329869 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR19 15527548 1329877 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR20 15527548 1329878 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR21 15527548 1329879 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR22 15527548 1329880 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR25 15527548 1329881 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR26 15527548 1329882 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR27 15527548 1329883 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR3 15527548 1329884 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR31 15527548 1329885 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR32 15527548 1329886 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR33 15527548 1329887 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR34 15527548 1329888 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR35 15527548 1329889 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR36 15527548 1329890 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR37 15527548 1329891 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR39 15527548 1329892 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR4 15527548 1329893 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR42 15527548 1329894 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR45 15527548 1329895 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR50 15527548 1329896 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR52 15527548 1329897 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR55 15527548 1329898 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR56 15527548 1329899 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR6 15527548 1329900 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR61 15527548 1329820 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR62 15527548 1329821 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR63 15527548 1329822 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR64 15527548 1329901 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR65 15527548 1329902 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR68 15527548 1329903 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR75 15527548 1329905 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR78 15527548 1329906 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR79 15527548 1329907 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR82 15527548 1329908 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR83 15527548 1329904 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR84 15527548 1329909 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR85 15527548 1329910 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR87 15527548 1329911 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR88 15527548 1329912 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR97 15527548 1329824 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GPR98 15527548 1329830 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC16 GRAP2 15266025 1275913 However , neither inhibition of epidermal growth factor receptor (EGFR) activation with the tyrosine kinase inhibitor 4- ( 3-chloroanilino ) -6,7-dimethoxyquinazoline HCl ( AG-1478 ) or EGFR blocking antibody nor inhibition of extracellular signal regulated mitogen activated protein kinases with specific inhibitors *blocked* IL-1beta stimulation of MUC5AC [mucin] production . Positive_regulation MUC16 HCL1 2887352 75914 Intestinal release of [mucin] in *response* to and taurocholate : effect of indomethacin . Positive_regulation MUC16 HCL2 2887352 75915 Intestinal release of [mucin] in *response* to and taurocholate : effect of indomethacin . Positive_regulation MUC16 HCL3 2887352 75916 Intestinal release of [mucin] in *response* to and taurocholate : effect of indomethacin . Positive_regulation MUC16 HIF1A 16823775 1646068 Taken together , these studies implicate the mediated hypoxic *induced* expression of [mucin] 3 and associated ITF in the maintenance of intestinal barrier function under hypoxic conditions . Positive_regulation MUC16 HMGB1 22521432 2595713 We showed that markedly increased MUC8 expression , and that the expression of other [MUC] genes was also *regulated* by HMGB1 . Positive_regulation MUC16 HSPG2 16467705 1523548 Epithelial cultures exposed to IL-1beta demonstrate an increase in [mucin] secretion that is *blocked* by specific inhibitors of , PKC , and NOS , but not by inhibitors of calmodulin . Positive_regulation MUC16 HSPG2 21933938 2507008 We found that muscarinic induced [mucin] secretion by rat sublingual tubulo-acini was *dependent* upon activation and the subsequent increase in [ Ca ( 2+ ) ] ( i ) , and further identified a transient PKC independent component of secretion dependent upon Ca ( 2+ ) release from intracellular stores , whereas sustained secretion required entry of extracellular Ca ( 2+ ) . Positive_regulation MUC16 IFNG 16007204 1453000 Synergistic *induction* of the MUC4 [mucin] gene by and retinoic acid in human pancreatic tumour cells involves a reprogramming of signalling pathways . Positive_regulation MUC16 IFNG 19737027 2264220 We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and [MUC] expression is *regulated* by , interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen . Positive_regulation MUC16 IFNG 8812537 383377 , on the other hand , *induced* a highly significant increase in [CA-125] secretion in ovarian cancer cells , but did not influence the shedding of CA-125 in HPMCs . Positive_regulation MUC16 IFNG 8824555 385115 Expression of the tumor marker [CA-125] was *increased* by in ovarian carcinoma cells but not by any other treatment . Positive_regulation MUC16 IKBKB 17237423 1690001 A novel *role* for IkappaB kinase (IKK) alpha and in ERK dependent up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Positive_regulation MUC16 IL13 10562299 566976 Furthermore , recombinant IL-9 , but not IL-5 or , *stimulated* [mucin] synthesis . Positive_regulation MUC16 IL13 11133503 769155 *induces* [mucin] production by stimulating epidermal growth factor receptors and by activating neutrophils . Positive_regulation MUC16 IL13 11133503 769185 Present results show that a cascade of EGFR involving neutrophils is implicated in *induced* [mucin] expression in GC . Positive_regulation MUC16 IL13 11133503 769204 These findings indicate that EGFR signaling is involved in *induced* [mucin] production . Positive_regulation MUC16 IL13 11734470 885609 caused mucous metaplasia , *enhanced* [mucin] gene expression , enhanced tissue hyaluronic acid accumulation , and subepithelial fibrosis . Positive_regulation MUC16 IL13 15466377 1305536 We evaluated bronchial epithelial TGF-beta1 and TGF-beta2 expression and their effects on mucin expression , and the role of TGF-beta1 or TGF-beta2 in *induced* [mucin] expression . Positive_regulation MUC16 IL13 15466377 1305637 A neutralizing TGF-beta2 antibody partially inhibited *induced* [mucin] expression . Positive_regulation MUC16 IL13 15466377 1305667 *induced* [mucin] expression may occur in part through TGF-beta2 up-regulation . Positive_regulation MUC16 IL13 15502346 1327281 GM6001 , a broad-spectrum inhibitor for MMP/ADAM , inhibited *induced* [mucin] gene expression and mucus production as measured by periodic acid-Schiff staining . Positive_regulation MUC16 IL13 16980555 1682713 However , there was constitutive release of TGF-alpha from normal human bronchial epithelial cells , and inhibition of TGF-alpha or EGFR reduced both constitutive and *induced* [mucin] production . Positive_regulation MUC16 IL13 18063838 1889377 In contrast , *induced* airway epithelial cell mucous cell hyperplasia , [mucin] and mucin related gene expression , epidermal growth factor receptor mRNA , and epidermal growth factor receptor activation along with airway hyperreactivity in WT mice but not in GGT ( enu1 ) mice . Positive_regulation MUC16 IL13 18596559 1953780 IL-4 , IL-9 , and significantly *increased* epithelial [mucin] expression ( P < .05 ) . Positive_regulation MUC16 IL13 21655064 2442190 However , scutellarin failed to inhibit MUC5AC [mucin] production *induced* by . Positive_regulation MUC16 IL13 22092504 2509151 The effect of GCS on *induced* [mucin] production is not well characterized . Positive_regulation MUC16 IL13 22092504 2509181 The aim of this study was to evaluate the effect of dexamethasone ( Dex ) , a potent synthetic GCS , on *induced* MUC5AC [mucin] expression and goblet cell proliferation in differentiated normal human bronchial epithelial cells ( NHBECs ) . Positive_regulation MUC16 IL13 22859374 2692234 Knockdown of Gab2 in human airway epithelial cells in vitro decreases *induced* expression of [mucin] genes . Positive_regulation MUC16 IL13 23449738 2803754 In the ovalbumin induced lung inflammation model , the bifunctional IL-4/IL-13 antagonist reduced the IL-4 dependent rise in serum IgE titers , and reduced *dependent* airway hyperresponsiveness , lung inflammation , [mucin] gene expression , and serum chitinase responses . Positive_regulation MUC16 IL17A 16859642 1592427 Histological and immunohistochemical analyses revealed that *increased* the [mucin] production and number of tracheal epithelial cells in air-liquid interface cultures . Positive_regulation MUC16 IL1B 12391274 1007519 These results suggest a role for PGE ( 2 ) in *induced* [mucin] synthesis in NCI-H292 cells . Positive_regulation MUC16 IL1B 12391274 1007537 Furthermore , the addition of PGE ( 2 ) to cells overcame the inhibitory effects of both MAPK inhibitors in *induced* [mucin] production . Positive_regulation MUC16 IL1B 12482999 1024555 *induces* MUC2 gene expression and [mucin] secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation MUC16 IL1B 12482999 1024586 In cultured human airway NCI-H292 epithelial cells , the steady state of the mRNA level of MUC2 gene expression and [mucin] secretion *induced* by were determined by reverse transcriptase-polymerase chain reaction ( RT-PCR ) , enzyme immunoassay , and immunoblot analysis . Positive_regulation MUC16 IL1B 12482999 1024601 PD98059 ( MEK/ERK inhibitor ) suppressed *mediated* MUC2 gene expression and [mucin] secretion , while SB203580 ( p38 inhibitor ) did not . Positive_regulation MUC16 IL1B 12482999 1024616 Ro31-8220 ( PKC inhibitor ) inhibited *mediated* MUC2 gene expression and [mucin] secretion . Positive_regulation MUC16 IL1B 12869928 1112242 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Positive_regulation MUC16 IL1B 12869928 1112272 *upregulates* [mucin] secretion from cultured middle ear epithelial cells in a dose- and time dependent manner . Positive_regulation MUC16 IL1B 15266025 1275872 *induced* [mucin] production in human airway epithelium is mediated by cyclooxygenase-2 , prostaglandin E2 receptors , and cyclic AMP-protein kinase A signaling . Positive_regulation MUC16 IL1B 15668323 1382119 increased the thickness of conducting airways , *enhanced* [mucin] production , and caused lymphocytic aggregates in the airways . Positive_regulation MUC16 IL1B 16467705 1523528 Signaling pathways in *mediated* middle ear [mucin] secretion . Positive_regulation MUC16 IL1B 16467705 1523588 *stimulates* [mucin] secretion from middle ear epithelium and its effects can be reversed by IL-1betara . Positive_regulation MUC16 IL1B 20873538 2326423 These results suggest that may *enhance* [mucin] gene expression in cultured human nasal epithelial cells . Positive_regulation MUC16 IL33 23945235 2835943 In the mouse model , receptor signaling was *required* for Il13 and [mucin] gene expression , and Il33 gene expression was localized to a virus induced subset of airway serous cells and a constitutive subset of alveolar type 2 cells that are both linked conventionally to progenitor function . Positive_regulation MUC16 IL4 10229869 611199 *induces* [mucin] gene expression and goblet cell metaplasia in vitro and in vivo . Positive_regulation MUC16 IL4 10229869 611229 In this study we hypothesized that *induces* airway epithelial cell [mucin] gene expression and mucous glycoconjugate production by direct action on these cells . Positive_regulation MUC16 IL4 18596559 1953781 , IL-9 , and IL-13 significantly *increased* epithelial [mucin] expression ( P < .05 ) . Positive_regulation MUC16 IL4 19737027 2264221 We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and [MUC] expression is *regulated* by interferon (IFN)-gamma , , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen . Positive_regulation MUC16 IL5 10562299 566977 Furthermore , recombinant IL-9 , but not or IL-13 , *stimulated* [mucin] synthesis . Positive_regulation MUC16 IL6 11282555 799134 and TNF-alpha *stimulated* MUC5AC and MUC5B [mucin] secretion in a time dependent manner , both in pre-confluent and post-confluent cells . Positive_regulation MUC16 IL6 15016409 1220856 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Positive_regulation MUC16 IL6 15016409 1220886 *upregulates* [mucin] secretion from cultured middle ear epithelial cells in a dose- and time dependent manner . Positive_regulation MUC16 IL6 9266949 449640 These results indicate that [CA125] can be secreted by Ki-1 lymphoma cells and may *promote* the growth of Ki-1 lymphoma cells . Positive_regulation MUC16 IL8 11936905 927963 Dose- ( 2-200 ng/ml ) and time- ( 0-5 days ) response studies of *induced* [mucin] secretion were carried out . Positive_regulation MUC16 IL8 11936905 927978 and ( ii ) *stimulates* prolonged [mucin] secretion from goblet cells and may be involved in the maintenance of the disease in the chronic stage . Positive_regulation MUC16 IL8 19596978 2112010 *regulates* [mucin] gene expression at the posttranscriptional level in lung epithelial cells . Positive_regulation MUC16 IL9 10562299 566957 Allergen induced directly *stimulates* [mucin] transcription in respiratory epithelial cells . Positive_regulation MUC16 IL9 10562299 566978 Furthermore , recombinant , but not IL-5 or IL-13 , *stimulated* [mucin] synthesis . Positive_regulation MUC16 IL9 10837360 699375 Altogether , these results suggest that *upregulation* of [mucin] by might contribute to the pathogenesis of human inflammatory airway disorders , such as asthma . Positive_regulation MUC16 IL9 18596559 1953782 IL-4 , , and IL-13 significantly *increased* epithelial [mucin] expression ( P < .05 ) . Positive_regulation MUC16 JUN 15262961 1290122 Tobacco smoke control of [mucin] production in lung cells *requires* oxygen radicals and JNK . Positive_regulation MUC16 JUN 19956440 2172537 Ras-Raf1-ERK1/2 dependent activation positively *regulates* MUC5AC [mucin] induction by S. pneumoniae , whereas MEKK3-JNK1/2 dependent AP-1 activation negatively regulates it . Positive_regulation MUC16 LEO1 1540379 180752 Both NDGA and BPB blocked *stimulated* [mucin] release in a concentration dependent manner . Positive_regulation MUC16 LEO1 3653044 78296 These results are consistent with the hypothesis that *stimulates* secretion of [mucin] by activating biosynthesis of lipoxygenase products ( e.g. , peptidyl leukotrienes ) within epithelial cells of the respiratory mucosa . Positive_regulation MUC16 LEO1 8049080 267202 This study assessed the role of protein kinase C ( PKC ) in *induced* [mucin] release from primary cultures of feline tracheal epithelial cells ( FTEC ) . Positive_regulation MUC16 LEO1 8049080 267277 Coincubation of FTEC with PAF ( 5 microM ) and pharmacologic PKC inhibitors , sphingosine , H7 , or calphostin C , inhibited *induced* [mucin] secretion at 30 min . Positive_regulation MUC16 LEO1 8049080 267352 Determination of the specific PKC isozyme ( s ) involved in *induced* [mucin] release was performed by immunoblot analysis of the subcellular fractions using a battery of antibodies against various PKC isozymes ( anti-PKC alpha , beta , delta , gamma , epsilon , and zeta ) . Positive_regulation MUC16 LEO1 9552223 492388 In HT-29 cells , MMS-68 plus leukotriene C4 ( LTC4 ) induced a 50 % increase in mucin release over either secretagogue alone , and MMS-68 plus markedly *enhanced* [mucin] release by eightfold over either secretagogue . Positive_regulation MUC16 LEO1 9620929 510665 In this study , we examined the hypothesis that *induces* goblet cell hyperplasia and [mucin] gene expression . Positive_regulation MUC16 LEO1 9620929 510740 In rat tracheas studied by in situ hybridization , *induced* [mucin] MUC5 gene expression in epithelial cells that stained for mucosubstances . Positive_regulation MUC16 LEP 16455789 1534359 In human colonic goblet-like HT29-MTX cells expressing leptin receptors , *increased* [mucin] secretion by activating PKC- and PI3K dependent pathways . Positive_regulation MUC16 LEP 17495032 1766664 We recently showed that luminal strongly *stimulated* [mucin] secretion in vivo in rat colon . Positive_regulation MUC16 LEP 17495032 1766679 Finally , pathway inhibition experiments suggest that *increased* [mucin] expression by activating PKC- , phosphatidyl inositol 3-kinase- , and MAPK dependent pathways but not the JAK/STAT pathway . Positive_regulation MUC16 LEP 18181030 1895129 significantly *increased* [mucin] and tissue NO , restored GR and SOD activities and up-regulated GPx activity . Positive_regulation MUC16 LEP 22236547 2537991 *contributes* to [mucin] production in colonic epithelium and regulates carcinogenesis via various signalling pathways . Positive_regulation MUC16 LIPE 15328111 1287634 In this study , we investigated whether 3O-C ( 12 ) <-HSL> could *stimulate* the production of a major [mucin] core protein , MUC5AC . Positive_regulation MUC16 LPA 15485666 1320687 Nontypeable Haemophilus influenzae P6 *induces* MUC5AC [mucin] transcription via TLR2-TAK1 dependent p38 MAPK-AP1 and IKKbeta-IkappaBalpha-NF-kappaB signaling pathways . Positive_regulation MUC16 MAPK1 11481474 843723 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a ( Erk 1/2 ) , and *activation* of [mucin] transcription . Positive_regulation MUC16 MAPK1 16439799 1561250 The induction of [mucin] by flagellin in human lung epithelial cells ( NCIH292 ) is *dependent* on asialoGM1 ligation , ATP receptor signaling , Ca2+ mobilization , and activation . Positive_regulation MUC16 MAPK10 11481474 843724 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a ( Erk 1/2 ) , and *activation* of [mucin] transcription . Positive_regulation MUC16 MAPK11 11481474 843725 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a ( Erk 1/2 ) , and *activation* of [mucin] transcription . Positive_regulation MUC16 MAPK12 11481474 843726 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a ( Erk 1/2 ) , and *activation* of [mucin] transcription . Positive_regulation MUC16 MAPK13 11481474 843727 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a ( Erk 1/2 ) , and *activation* of [mucin] transcription . Positive_regulation MUC16 MAPK14 11481474 843728 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a ( Erk 1/2 ) , and *activation* of [mucin] transcription . Positive_regulation MUC16 MAPK15 11481474 843722 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a ( Erk 1/2 ) , and *activation* of [mucin] transcription . Positive_regulation MUC16 MAPK3 11481474 843729 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a ( Erk 1/2 ) , and *activation* of [mucin] transcription . Positive_regulation MUC16 MAPK3 16439799 1561251 The induction of [mucin] by flagellin in human lung epithelial cells ( NCIH292 ) is *dependent* on asialoGM1 ligation , ATP receptor signaling , Ca2+ mobilization , and activation . Positive_regulation MUC16 MAPK3 19956440 2172538 dependent AP-1 activation positively *regulates* MUC5AC [mucin] induction by S. pneumoniae , whereas MEKK3-JNK1/2 dependent AP-1 activation negatively regulates it . Positive_regulation MUC16 MAPK4 11481474 843730 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a ( Erk 1/2 ) , and *activation* of [mucin] transcription . Positive_regulation MUC16 MAPK6 11481474 843731 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a ( Erk 1/2 ) , and *activation* of [mucin] transcription . Positive_regulation MUC16 MAPK7 11481474 843732 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a ( Erk 1/2 ) , and *activation* of [mucin] transcription . Positive_regulation MUC16 MAPK8 11481474 843733 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a ( Erk 1/2 ) , and *activation* of [mucin] transcription . Positive_regulation MUC16 MAPK9 11481474 843734 This response links ASGM1 to cytoplasmic signaling molecules and results in activation of phospholipase C , Ca ( 2+ ) mobilization , phosphorylation of a ( Erk 1/2 ) , and *activation* of [mucin] transcription . Positive_regulation MUC16 MAPKAPK2 20724476 2330221 Physiologic relevance of these findings was confirmed by differences of K20-Ser ( 13 ) phosphorylation between the ileum of wild-type and MK2/3-deficient mice and by demonstrating p38- and *dependent* [mucin] secretion of HT29 cells . Positive_regulation MUC16 MARCKS 18314541 1919472 The results provide the first evidence that CSP and HSP70 , and their interactions with , are *involved* in [mucin] secretion . Positive_regulation MUC16 MME 9849009 554086 The effects of SP on the secretory rate or release of radiolabeled [mucin] were not *potentiated* by an inhibitor , thiorphan ( 10 ( -5 ) M ) . Positive_regulation MUC16 MMP7 18436821 1900345 and neutrophil elastase *induced* the release of [MUC16] but not of MUC1 or MUC4 . Positive_regulation MUC16 MMP9 18006877 1882849 Acrolein activated *contributes* to persistent [mucin] production . Positive_regulation MUC16 MMP9 19389382 2089298 *Role* of in lipopolysaccharide induced [mucin] production in human airway epithelial cells . Positive_regulation MUC16 MUC2 14501822 1144472 The normal endocervical epithelium was characterized by predominant sulfomucin and MUC1 expression in all sites and MUC5AC expression in the surface epithelium , while was not detected at all and pyloric gland type [mucin] ( using antibody HIK1083 ) was *detected* in less than 1 % of cases . Positive_regulation MUC16 MUC3A 12740338 1088162 To determine whether increased epithelial cell mucin expression in response to Lactobacillus strains *results* in increased extracellular secretion of MUC3 mucins and the importance of epithelial cell adherence in modulation of MUC3 [mucin] expression . Positive_regulation MUC16 MUC4 11751498 889915 [Mucin (MUC)] gene expression in human pancreatic adenocarcinoma and chronic pancreatitis : a potential *role* of as a tumor marker of diagnostic significance . Positive_regulation MUC16 MUC5AC 17568580 1774210 NHCE cells expressed MUC1 , MUC4 , [MUC16] , and MUC5AC mRNA , and production and secretion *increased* in a time dependent manner after culture under ALI conditions . Positive_regulation MUC16 MUC5AC 19956440 2172539 Ras-Raf1-ERK1/2 dependent AP-1 activation positively regulates [mucin] *induction* by S. pneumoniae , whereas MEKK3-JNK1/2 dependent AP-1 activation negatively regulates it . Positive_regulation MUC16 MUC5AC 19956440 2172665 Therefore , our data unveiled a novel signaling mechanism underlying the tight regulation of [mucin] *induction* by S. pneumoniae and may lead to the development of new therapeutic strategy for reducing mucus overproduction in both OM and COPD . Positive_regulation MUC16 MUC5AC 21146382 2437429 Glycyrrhizin and carbenoxolone were found to *inhibit* the production of MUC5AC [mucin] protein induced by EGF or PMA , and both compounds also inhibited the expression of mucin gene induced by EGF or PMA . Positive_regulation MUC16 MUC5AC 21442679 2421951 Oleanolic acid and ursolic acid were found to *inhibit* the production of MUC5AC [mucin] protein induced by EGF and PMA , and both compounds also inhibited the expression of mucin gene induced by EGF and PMA . Positive_regulation MUC16 MUC5AC 22659655 2610820 The levels of intracellular and secreted MUC5AC of cold treated group were significantly higher than those of control group ( P < 0.05 ) . BCTC attenuated the cold induced synthesis and secretion of MUC5AC when compared with cold treated group ( P < 0.05 ) . Transfection of 16HBE cells with the MARCKS-PSD mutant cDNA resulted in significant inhibition of [mucin] secretion in *response* to cold , and significantly higher level of intracellular than that of control group ( P < 0.01 ) , whereas transfection with the vector DNA or the wild-type MARCKS cDNA had no effect on the mucin synthesis and secretion in response to cold ( P > 0.05 ) . Positive_regulation MUC16 MYD88 18978302 2053261 TLR3 mediated [mucin] induction was negatively *regulated* by , and only partially dependent on TRIF , which suggests a departure from well documented TLR3 signaling paradigm that mediates inflammatory and other innate defense gene inductions . Positive_regulation MUC16 NA 15643543 1349816 The results were as follows : ursolic acid , betulin , MESNA and *increased* [mucin] release ( 40-50 % above control ) at the highest concentrations ( 10 ( -5 ) M-10 ( -3 ) M ) . Positive_regulation MUC16 NAB1 2306105 129826 Among active analogs of 1,25- ( OH ) 2D3 , 26,26,26,27,27,27-hexafluoro-1,25- ( OH ) 2D3 ( F6-1,25- ( OH ) 2D3 ) , 24,24-difluoro-24-homo-1,25- ( OH ) 2D3 , and 26,27-dimethyl-1,25- ( OH ) 2D3 were 100- , 10- , and 5-fold , respectively , more effective than 1,25- ( OH ) 2D3 in enhancing *induced* [mucin] production . Positive_regulation MUC16 NAB2 2306105 129827 Among active analogs of 1,25- ( OH ) 2D3 , 26,26,26,27,27,27-hexafluoro-1,25- ( OH ) 2D3 ( F6-1,25- ( OH ) 2D3 ) , 24,24-difluoro-24-homo-1,25- ( OH ) 2D3 , and 26,27-dimethyl-1,25- ( OH ) 2D3 were 100- , 10- , and 5-fold , respectively , more effective than 1,25- ( OH ) 2D3 in enhancing *induced* [mucin] production . Positive_regulation MUC16 NFKB1 12237307 1012385 Here , we report that the bacterium nontypeable Haemophilus influenzae ( NTHi ) , an important human respiratory pathogen , utilizes the TGF-beta-Smad signaling pathway together with the TLR2-MyD88-TAK1-NIK-IKKbeta/gamma-IkappaBalpha pathway to mediate *dependent* MUC2 [mucin] transcription . Positive_regulation MUC16 NFKB1 9576950 502910 Activated binds to a kappaB site in the 5'-flanking region of the MUC2 gene and *activates* MUC2 [mucin] transcription . Positive_regulation MUC16 NKX2-1 21126317 2372480 The mouse Muc5b [mucin] gene is transcriptionally *regulated* by ( TTF-1 ) and GATA-6 transcription factors . Positive_regulation MUC16 NOS1 16467705 1523549 Epithelial cultures exposed to IL-1beta demonstrate an increase in [mucin] secretion that is *blocked* by specific inhibitors of PC-PLC , PKC , and , but not by inhibitors of calmodulin . Positive_regulation MUC16 NOS1 16847357 1588198 activity in rat gastric mucosa *contributes* to [mucin] synthesis elicited by calcitonin gene related peptide . Positive_regulation MUC16 NOS2 16847357 1588199 activity in rat gastric mucosa *contributes* to [mucin] synthesis elicited by calcitonin gene related peptide . Positive_regulation MUC16 NOS3 16847357 1588200 activity in rat gastric mucosa *contributes* to [mucin] synthesis elicited by calcitonin gene related peptide . Positive_regulation MUC16 NOX1 15640347 1362859 Inhibition of epithelial or knockdown of Duox1 expression with small interfering RNA *prevented* ROS generation , TGF-alpha release , and [mucin] expression by these stimuli , implicating Duox1 in TACE activation and mucin expression . Positive_regulation MUC16 NOX3 15640347 1362860 Inhibition of epithelial or knockdown of Duox1 expression with small interfering RNA *prevented* ROS generation , TGF-alpha release , and [mucin] expression by these stimuli , implicating Duox1 in TACE activation and mucin expression . Positive_regulation MUC16 NOX4 15640347 1362861 Inhibition of epithelial or knockdown of Duox1 expression with small interfering RNA *prevented* ROS generation , TGF-alpha release , and [mucin] expression by these stimuli , implicating Duox1 in TACE activation and mucin expression . Positive_regulation MUC16 NOX5 15640347 1362858 Inhibition of epithelial or knockdown of Duox1 expression with small interfering RNA *prevented* ROS generation , TGF-alpha release , and [mucin] expression by these stimuli , implicating Duox1 in TACE activation and mucin expression . Positive_regulation MUC16 NTS 8172620 255402 Role of calcium in carbachol- and *induced* [mucin] exocytosis in a human colonic goblet cell line and cross-talk with the cyclic AMP pathway . Positive_regulation MUC16 OPN1MW 21249146 2380041 Shigella and IFN-? *induced* the highest [mucin] secretion and greatest impairment in tight junctions and , consequently , translocation of gliadin fragments into the lamina propria . Positive_regulation MUC16 P2RX4 16439799 1561252 The induction of [mucin] by flagellin in human lung epithelial cells ( NCIH292 ) is *dependent* on asialoGM1 ligation , signaling , Ca2+ mobilization , and Erk1/2 activation . Positive_regulation MUC16 P2RY2 15218074 1289223 SPOC1 airway goblet cells secrete [mucin] in *response* to receptor agonists and to secretagogues , phorbol 12-myristate 13-acetate ( PMA ) and ionomycin , which mobilize elements of the phospholipase C pathway , PKC and Ca2+ , respectively . Positive_regulation MUC16 P2RY4 18604596 1941652 Luminal A ( 2b ) , P2Y(2) , , and P2Y(6) receptors are *involved* in fluid and Cl ( - ) , HCO ( 3 ) ( - ) , K ( + ) , or [mucin] secretion . Positive_regulation MUC16 P2RY6 18604596 1941653 Luminal A ( 2b ) , P2Y(2) , P2Y(4) , and receptors are *involved* in fluid and Cl ( - ) , HCO ( 3 ) ( - ) , K ( + ) , or [mucin] secretion . Positive_regulation MUC16 PACS1 23064255 2768948 *stimulate* oral [mucin] levels . Positive_regulation MUC16 PACS2 23064255 2768947 *stimulate* oral [mucin] levels . Positive_regulation MUC16 PAF1 1540379 180750 Both NDGA and BPB blocked *stimulated* [mucin] release in a concentration dependent manner . Positive_regulation MUC16 PAF1 3653044 78294 These results are consistent with the hypothesis that *stimulates* secretion of [mucin] by activating biosynthesis of lipoxygenase products ( e.g. , peptidyl leukotrienes ) within epithelial cells of the respiratory mucosa . Positive_regulation MUC16 PAF1 8049080 267200 This study assessed the role of protein kinase C ( PKC ) in *induced* [mucin] release from primary cultures of feline tracheal epithelial cells ( FTEC ) . Positive_regulation MUC16 PAF1 8049080 267275 Coincubation of FTEC with PAF ( 5 microM ) and pharmacologic PKC inhibitors , sphingosine , H7 , or calphostin C , inhibited *induced* [mucin] secretion at 30 min . Positive_regulation MUC16 PAF1 8049080 267350 Determination of the specific PKC isozyme ( s ) involved in *induced* [mucin] release was performed by immunoblot analysis of the subcellular fractions using a battery of antibodies against various PKC isozymes ( anti-PKC alpha , beta , delta , gamma , epsilon , and zeta ) . Positive_regulation MUC16 PAF1 9552223 492386 In HT-29 cells , MMS-68 plus leukotriene C4 ( LTC4 ) induced a 50 % increase in mucin release over either secretagogue alone , and MMS-68 plus markedly *enhanced* [mucin] release by eightfold over either secretagogue . Positive_regulation MUC16 PAF1 9620929 510663 In this study , we examined the hypothesis that *induces* goblet cell hyperplasia and [mucin] gene expression . Positive_regulation MUC16 PAF1 9620929 510738 In rat tracheas studied by in situ hybridization , *induced* [mucin] MUC5 gene expression in epithelial cells that stained for mucosubstances . Positive_regulation MUC16 PAK2 17555715 1753037 Opposing *roles* of and PAK4 in synergistic induction of MUC5AC [mucin] by bacterium NTHi and EGF . Positive_regulation MUC16 PAK4 17555715 1753036 Opposing *roles* of PAK2 and in synergistic induction of MUC5AC [mucin] by bacterium NTHi and EGF . Positive_regulation MUC16 PAM 17600317 1804650 LPS and significantly *increased* [mucin] expression in airway mucosa and Calu-3 cells ( P < 0.05 ) . Positive_regulation MUC16 PAM 17600317 1804665 In contrast , DEX significantly reduced LPS- and *induced* mucin expression in explanted mucosal tissue and [mucin] expression in Calu-3 cells ( P < 0.05 ) . Positive_regulation MUC16 PAM 17600317 1804695 In contrast , ACC significantly decreased LPS- and *induced* [mucin] expression ( P < 0.05 ) . Positive_regulation MUC16 PAM 17600317 1804740 ACC decreased LPS- and *induced* [mucin] expression , but this effect was not significant ( P > 0.05 ) . Positive_regulation MUC16 PCSK2 22829138 2701324 Removal of Ca ( 2+ ) by Ca ( 2+ ) chelator BAPTA or inhibition of protein kinase A (PKA) by the PKA inhibitors H-89 each partially reduced *induced* [mucin] secretion . Positive_regulation MUC16 PGD 11139429 758840 ( 2 ) , L-644,698 and PGE ( 2 ) ( an established mucin secretagogue ) potently *stimulated* [mucin] secretion in LS174T cells in a concentration dependent manner ( EC ( 50 ) < 50 nM ) . Positive_regulation MUC16 PGD 11139429 758855 However , BW A868C effectively antagonized only the [mucin] secretion *mediated* by ( 2 ) and L-644,698 and not PGE ( 2 ) . Positive_regulation MUC16 PIK3CA 18154934 1847564 Activation of MUC1 [mucin] expression by bile acids in human esophageal adenocarcinomatous cells and tissues is *mediated* by the . Positive_regulation MUC16 PIK3CA 25019985 2953091 Secretion of [mucin] is *enhanced* by activation of . Positive_regulation MUC16 PIK3R1 18154934 1847565 Activation of MUC1 [mucin] expression by bile acids in human esophageal adenocarcinomatous cells and tissues is *mediated* by the . Positive_regulation MUC16 PIK3R1 25019985 2953092 Secretion of [mucin] is *enhanced* by activation of . Positive_regulation MUC16 PLA2G1B 11484413 844651 ATP induced [mucin] release from cultured airway goblet cell *involves* , in part , activation of . Positive_regulation MUC16 PLA2G1B 11484413 844681 These results suggest that is *involved* in ATP induced [mucin] release and its activation is sequential to the PLC-PKC pathway . Positive_regulation MUC16 PLEC 22103442 2557445 We demonstrate that represses the expression of FoxA2 in mouse airways and in bronchial epithelial cells cultured at an air-liquid interface or conventionally , resulting in GCH , *increased* MUC5B [mucin] gene expression and mucus hypersecretion . Positive_regulation MUC16 PMS1 22829138 2701341 The combination of BAPTA and H-89 completely prevented [mucin] secretion *mediated* by . Positive_regulation MUC16 PMS2 22829138 2701342 The combination of BAPTA and H-89 completely prevented [mucin] secretion *mediated* by . Positive_regulation MUC16 PPARG 12749691 1089072 Using gastric mucosal cells in culture , we show that activation of with a specific synthetic agonist , ciglitazone , *prevents* in a dose dependent fashion ( up to 90.2 % ) the LPS induced reduction in [mucin] synthesis , and the effect is reflected in a marked decrease in the LPS induced apoptosis ( 72.4 % ) , NO generation ( 80.1 % ) , and the expression of NOS-2 activity ( 90 % ) . Positive_regulation MUC16 PPARG 15185749 1256207 We show that activation of with a specific agonist , ciglitazone , *prevents* the LPS induced reduction in [mucin] synthesis , and the effect is reflected in a marked decrease in apoptosis , caspase-3 activity and NO generation . Positive_regulation MUC16 PPARG 15265318 1275287 Using gastric mucosal cells in culture , we show that activation of with a specific agonist , ciglitazone , *prevents* the LPS induced reduction in [mucin] synthesis , and the effect is reflected in a marked decrease in apoptosis , caspase-3 activity and NO generation . Positive_regulation MUC16 PPARG 16443643 1567255 However , no data are available on the *role* of in smoke induced [mucin] production . Positive_regulation MUC16 PTEN 16443643 1567330 PPAR-gamma agonists or specific inhibitors of phosphoinositide 3-kinase exert inhibition of cigarette smoke *induced* [mucin] production , with the upregulation of signaling and downregulation of Akt expression . Positive_regulation MUC16 PTGDR 11139429 758825 The human *stimulates* [mucin] secretion in LS174T cells . Positive_regulation MUC16 PTGS2 15266025 1275873 Interleukin-1beta induced [mucin] production in human airway epithelium is *mediated* by , prostaglandin E2 receptors , and cyclic AMP-protein kinase A signaling . Positive_regulation MUC16 PTPN6 20117097 2213197 In this study , we investigated the *role* of in [mucin] secretion triggered by oxidative stress . Positive_regulation MUC16 RAF1 19956440 2172540 dependent AP-1 activation positively *regulates* MUC5AC [mucin] induction by S. pneumoniae , whereas MEKK3-JNK1/2 dependent AP-1 activation negatively regulates it . Positive_regulation MUC16 RARA 10024510 590818 In contrast , the RARgamma antagonist only weakly inhibited *induced* [mucin] gene expression , but completely blocked mucin gene expression induced by the RARgamma-selective retinoid . Positive_regulation MUC16 RARA 10024510 590833 Our studies indicate that is the major retinoid receptor subtype mediating RA-dependent mucin gene expression and mucous cell differentiation , but that the RARgamma isotype can also *induce* [mucin] genes . Positive_regulation MUC16 RARB 10024510 590848 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Positive_regulation MUC16 RELA 12237307 1012386 Here , we report that the bacterium nontypeable Haemophilus influenzae ( NTHi ) , an important human respiratory pathogen , utilizes the TGF-beta-Smad signaling pathway together with the TLR2-MyD88-TAK1-NIK-IKKbeta/gamma-IkappaBalpha pathway to mediate *dependent* MUC2 [mucin] transcription . Positive_regulation MUC16 RELA 9576950 502911 Activated binds to a kappaB site in the 5'-flanking region of the MUC2 gene and *activates* MUC2 [mucin] transcription . Positive_regulation MUC16 SCT 9178925 434314 Carbachol , , CCK-8 and prostaglandin E2 ( PGE2 ) strongly *stimulated* [mucin] secretion , and gastrin I weakly did . Positive_regulation MUC16 SETD2 21544845 2554284 These effects are prevented by small interfering RNA ( siRNA ) for HIF-1a , indicating that cigarette smoke induced [mucin] production is *dependent* . Positive_regulation MUC16 SFTPA2 21146625 2390167 A significant reduction was also observed for MUC5AC gene expression with the two agents ( P < 0.05 ) except for *induced* [mucin] gene expression in vitro ( P > 0.05 ) . Positive_regulation MUC16 SHH 19104239 2018775 In vitro , enhances gastric acid secretion and *induces* [mucin] expression . Positive_regulation MUC16 SLC25A1 16527336 1568029 [CA125] was rapidly decreased after first operation , but levels repeated distinctive fluctuations and NSE abruptly *increased* during the last few months before death . Positive_regulation MUC16 SNAP25 12972643 1143530 PMA , PA , and LPS *increased* MUC5AC gene expression and [mucin] protein production , effects that were prevented by pretreatment with AG1478 , a selective inhibitor of EGFR phosphorylation and by preincubation with an EGFR neutralizing Ab or with a TGF-alpha neutralizing Ab , implicating ligand ( TGF-alpha ) -dependent EGFR phosphorylation in mucin production . Positive_regulation MUC16 SOS1 1473434 207261 Sucralfate and did not *stimulate* [mucin] release in the canine explants ; Positive_regulation MUC16 SOS2 1473434 207262 Sucralfate and did not *stimulate* [mucin] release in the canine explants ; Positive_regulation MUC16 SOX2 18027866 1860655 Aberrant expression of *upregulates* MUC5AC gastric foveolar [mucin] in mucinous cancers of the colorectum and related lesions . Positive_regulation MUC16 SP1 14570593 1199823 Transcriptional activation of the murine Muc5ac [mucin] gene in epithelial cancer cells by TGF-beta/Smad4 signalling pathway is *potentiated* by . Positive_regulation MUC16 SPHK1 19835973 2203011 *regulates* [mucin] production via ERK phosphorylation . Positive_regulation MUC16 SPHK1 19835973 2203073 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Positive_regulation MUC16 SPHK2 19835973 2203074 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Positive_regulation MUC16 TACR1 10657498 578334 Several investigators hypothesize that [mucin] secretion from airway epithelium is *mediated* . Positive_regulation MUC16 TCF12 15541382 1336955 The murine Muc2 [mucin] gene is transcriptionally *regulated* by the zinc-finger GATA-4 in intestinal cells . Positive_regulation MUC16 TCF15 15541382 1336956 The murine Muc2 [mucin] gene is transcriptionally *regulated* by the zinc-finger GATA-4 in intestinal cells . Positive_regulation MUC16 TCF19 15541382 1336957 The murine Muc2 [mucin] gene is transcriptionally *regulated* by the zinc-finger GATA-4 in intestinal cells . Positive_regulation MUC16 TCF20 15541382 1336958 The murine Muc2 [mucin] gene is transcriptionally *regulated* by the zinc-finger GATA-4 in intestinal cells . Positive_regulation MUC16 TCF21 15541382 1336959 The murine Muc2 [mucin] gene is transcriptionally *regulated* by the zinc-finger GATA-4 in intestinal cells . Positive_regulation MUC16 TCF23 15541382 1336963 The murine Muc2 [mucin] gene is transcriptionally *regulated* by the zinc-finger GATA-4 in intestinal cells . Positive_regulation MUC16 TCF24 15541382 1336965 The murine Muc2 [mucin] gene is transcriptionally *regulated* by the zinc-finger GATA-4 in intestinal cells . Positive_regulation MUC16 TCF25 15541382 1336964 The murine Muc2 [mucin] gene is transcriptionally *regulated* by the zinc-finger GATA-4 in intestinal cells . Positive_regulation MUC16 TCF3 15541382 1336960 The murine Muc2 [mucin] gene is transcriptionally *regulated* by the zinc-finger GATA-4 in intestinal cells . Positive_regulation MUC16 TCF4 15541382 1336961 The murine Muc2 [mucin] gene is transcriptionally *regulated* by the zinc-finger GATA-4 in intestinal cells . Positive_regulation MUC16 TCF7 15541382 1336962 The murine Muc2 [mucin] gene is transcriptionally *regulated* by the zinc-finger GATA-4 in intestinal cells . Positive_regulation MUC16 TGFB1 15466377 1305534 We evaluated bronchial epithelial TGF-beta1 and TGF-beta2 expression and their effects on mucin expression , and the *role* of or TGF-beta2 in interleukin (IL)-13 induced [mucin] expression . Positive_regulation MUC16 TGFB1 15466377 1305607 TGF-beta2 , but not , *increased* [mucin] expression in cultured epithelial cells from both subject groups . Positive_regulation MUC16 TGFB2 10938282 744018 Retinoic acid dependent *induction* of MUC4 [mucin] expression in human pancreatic tumor cells follows retinoic acid receptor-alpha signaling pathway . Positive_regulation MUC16 TGFB2 15466377 1305485 *induces* bronchial epithelial [mucin] expression in asthma . Positive_regulation MUC16 TGFB2 15466377 1305535 We evaluated bronchial epithelial TGF-beta1 and TGF-beta2 expression and their effects on mucin expression , and the *role* of TGF-beta1 or in interleukin (IL)-13 induced [mucin] expression . Positive_regulation MUC16 TGFB2 15466377 1305608 , but not TGF-beta1 , *increased* [mucin] expression in cultured epithelial cells from both subject groups . Positive_regulation MUC16 TGFB2 15466377 1305652 These data suggest that production by asthmatic bronchial epithelial cells may *increase* airway [mucin] expression . Positive_regulation MUC16 TLR2 15843573 1398511 signaling is *critical* for Mycoplasma pneumoniae induced airway [mucin] expression . Positive_regulation MUC16 TLR2 17194718 1732402 A deficient signaling *promotes* airway [mucin] production in Mycoplasma pneumoniae infected allergic mice . Positive_regulation MUC16 TLR3 18978302 2053260 mediated [mucin] *induction* was negatively regulated by MyD88 , and only partially dependent on TRIF , which suggests a departure from well documented TLR3 signaling paradigm that mediates inflammatory and other innate defense gene inductions . Positive_regulation MUC16 TMPRSS11D 14500256 1218209 Human *increases* [mucin] gene expression in airway epithelial cells . Positive_regulation MUC16 TNF 10030839 591791 *stimulates* [mucin] secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro . Positive_regulation MUC16 TNF 10030839 591806 In this study , we investigated potential signaling pathways mediating *induced* [mucin] secretion using guinea pig tracheal epithelial ( GPTE ) cells in air-liquid interface culture . Positive_regulation MUC16 TNF 10030839 591821 Exogenously applied ( human recombinant ) *stimulated* [mucin] secretion in a concentration dependent manner , with maximal effects at 10 to 15 ng/ml ( 286 to 429 U/ml ) . Positive_regulation MUC16 TNF 10030839 591836 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Positive_regulation MUC16 TNF 10030839 591868 Collectively , the results suggest that *stimulates* secretion of [mucin] by GPTE cells via a mechanism ( s ) dependent on PC-PLC and PKC , and involving activation of NOS , generation of NO , production of cGMP , and activation of PKG . Positive_regulation MUC16 TNF 10950784 723459 *Induction* of [mucin] gene expression in middle ear of rats by : potential cause for mucoid otitis media . Positive_regulation MUC16 TNF 11052828 743485 *stimulates* MUC5AC [mucin] secretion in a dose dependent manner , with 20 ng/ml producing maximal stimulation . Positive_regulation MUC16 TNF 11282555 799133 IL-6 and *stimulated* MUC5AC and MUC5B [mucin] secretion in a time dependent manner , both in pre-confluent and post-confluent cells . Positive_regulation MUC16 TNF 12018326 942419 Recent studies demonstrated that , present in human middle ear effusion , *stimulated* mucin production in vitro and up-regulated [mucin] gene expression in vivo . Positive_regulation MUC16 TNF 15696080 1372026 Niflumic acid and MSI-2216 reduce *induced* [mucin] expression in human airway mucosa . Positive_regulation MUC16 TNF 15696080 1372043 Unstimulated and *induced* [mucin] expression could be decreased by NFA and MSI-2216 . Positive_regulation MUC16 TNF 16543607 1582105 We demonstrated that cigarette smoke extract (CSE) synergistically increased gene expression and protein production of MUC5AC [mucin] *induced* by LPS or in human airway epithelial NCI-H292 cells . Positive_regulation MUC16 TNF 18436821 1900341 *induced* the release of MUC1 , MUC4 , and [MUC16] from the HCLE surface . Positive_regulation MUC16 TNF 19053887 2017601 Both LPS and *increased* MUC5AC [mucin] production in vivo and in vitro , respectively , and fudosteine was found to reduce it by partially interfering with the kinase mediated inflammation pathway that activates the MUC5AC gene . Positive_regulation MUC16 TNF 23463646 2895466 Inhibition of *induced* MUC5AC [mucin] gene expression and production by wogonin through the inactivation of NF-?B signaling in airway epithelial cells . Positive_regulation MUC16 TNF 24348668 2881121 We investigated whether prunetin significantly affects *induced* MUC5AC [mucin] gene expression , production , inhibitory kappa B ( I?B ) degradation and nuclear factor kappa B ( NF-?B ) p65 translocation in human airway epithelial cells . Positive_regulation MUC16 TPP1 22901691 2715781 *stimulated* MUC2 and MUC4 gene expression as well as [mucin] secretion in HT29-MTX cells . Positive_regulation MUC16 TPP2 22901691 2715780 *stimulated* MUC2 and MUC4 gene expression as well as [mucin] secretion in HT29-MTX cells . Positive_regulation MUC16 TRPV1 22829138 2701309 Exposure of PMs to 16HBE cells was found to induce [mucin] secretion , as a *consequence* of sustained Ca ( 2+ ) influx and cAMP increase through receptors . Positive_regulation MUC16 UNC13B 17988208 1866753 These new data indicate that is responsible for regulating a baseline mucin secretory pathway in the airways and is not *essential* for purinergic agonist induced [mucin] secretion . Positive_regulation MUC16 UTP15 11694445 876689 However , only can *increase* [mucin] gene ( MUC5AC , MUC5B ) expression ; Positive_regulation MUC16 UTP15 11694445 876971 These findings are the first demonstration that , a pyrimidine nucleotide triphosphate , can *enhance* both mucin secretion and [mucin] gene expression through different signaling pathways . Positive_regulation MUC16 UTP15 12737291 1087610 Extracellular *regulates* a variety of biological functions in the airway epithelium , including chloride and fluid transport , mucociliary clearance and [mucin] secretion via the P2Y purinergic receptors . Positive_regulation MUC16 UTP15 12737291 1087794 In contrast , did not *enhance* [mucin] and lysozyme mRNA expression until 72 h after treatment . Positive_regulation MUC16 UTP15 14710912 1181499 and ATPgammaS increased [ Ca2+ ] i via caffeine-sensitive pathways , and these two agonists *stimulated* [mucin] secretion to a similar magnitude without their gene enhancement . Positive_regulation MUC16 UTP15 16139976 1475125 *induced* [mucin] secretion was quantified by an immunoblotting assay . Positive_regulation MUC16 UTP15 16139976 1475215 *induced* [mucin] secretion was inhibited by a Ca ( 2+ ) chelating agent , BAPTA-AM , and was stimulated by ionomycin . Positive_regulation MUC16 UTP15 16139976 1475320 *induced* [mucin] secretion was also suppressed by U73122 and 2-APB , while Calphostin C suppressed it to a small extent and PD98059 was ineffective . Positive_regulation MUC16 UTP15 16139976 1475410 *induced* [mucin] secretion in NHMEE cells is strongly dependent on Ca ( 2+ ) - and IP ( 3 ) . Positive_regulation MUC16 UTP15 17250694 1690876 As *stimulates* both [mucin] secretion and Cl ion transport via a Ca ( 2+ ) -dependent pathway , the purpose of this study is to determine whether IL-9 and IL-13 affect UTP induced Cl ion transport in human bronchial epithelial cell line 16HBE cells , and if they do , to elucidate whether such an effect is associated with hCLCA1 expression . Positive_regulation MUC16 UTP18 11694445 876687 However , only can *increase* [mucin] gene ( MUC5AC , MUC5B ) expression ; Positive_regulation MUC16 UTP18 11694445 876969 These findings are the first demonstration that , a pyrimidine nucleotide triphosphate , can *enhance* both mucin secretion and [mucin] gene expression through different signaling pathways . Positive_regulation MUC16 UTP18 12737291 1087608 Extracellular *regulates* a variety of biological functions in the airway epithelium , including chloride and fluid transport , mucociliary clearance and [mucin] secretion via the P2Y purinergic receptors . Positive_regulation MUC16 UTP18 12737291 1087792 In contrast , did not *enhance* [mucin] and lysozyme mRNA expression until 72 h after treatment . Positive_regulation MUC16 UTP18 14710912 1181497 and ATPgammaS increased [ Ca2+ ] i via caffeine-sensitive pathways , and these two agonists *stimulated* [mucin] secretion to a similar magnitude without their gene enhancement . Positive_regulation MUC16 UTP18 16139976 1475123 *induced* [mucin] secretion was quantified by an immunoblotting assay . Positive_regulation MUC16 UTP18 16139976 1475213 *induced* [mucin] secretion was inhibited by a Ca ( 2+ ) chelating agent , BAPTA-AM , and was stimulated by ionomycin . Positive_regulation MUC16 UTP18 16139976 1475318 *induced* [mucin] secretion was also suppressed by U73122 and 2-APB , while Calphostin C suppressed it to a small extent and PD98059 was ineffective . Positive_regulation MUC16 UTP18 16139976 1475408 *induced* [mucin] secretion in NHMEE cells is strongly dependent on Ca ( 2+ ) - and IP ( 3 ) . Positive_regulation MUC16 UTP18 17250694 1690874 As *stimulates* both [mucin] secretion and Cl ion transport via a Ca ( 2+ ) -dependent pathway , the purpose of this study is to determine whether IL-9 and IL-13 affect UTP induced Cl ion transport in human bronchial epithelial cell line 16HBE cells , and if they do , to elucidate whether such an effect is associated with hCLCA1 expression . Positive_regulation MUC16 UTP20 11694445 876685 However , only can *increase* [mucin] gene ( MUC5AC , MUC5B ) expression ; Positive_regulation MUC16 UTP20 11694445 876967 These findings are the first demonstration that , a pyrimidine nucleotide triphosphate , can *enhance* both mucin secretion and [mucin] gene expression through different signaling pathways . Positive_regulation MUC16 UTP20 12737291 1087606 Extracellular *regulates* a variety of biological functions in the airway epithelium , including chloride and fluid transport , mucociliary clearance and [mucin] secretion via the P2Y purinergic receptors . Positive_regulation MUC16 UTP20 12737291 1087790 In contrast , did not *enhance* [mucin] and lysozyme mRNA expression until 72 h after treatment . Positive_regulation MUC16 UTP20 14710912 1181495 and ATPgammaS increased [ Ca2+ ] i via caffeine-sensitive pathways , and these two agonists *stimulated* [mucin] secretion to a similar magnitude without their gene enhancement . Positive_regulation MUC16 UTP20 16139976 1475121 *induced* [mucin] secretion was quantified by an immunoblotting assay . Positive_regulation MUC16 UTP20 16139976 1475211 *induced* [mucin] secretion was inhibited by a Ca ( 2+ ) chelating agent , BAPTA-AM , and was stimulated by ionomycin . Positive_regulation MUC16 UTP20 16139976 1475316 *induced* [mucin] secretion was also suppressed by U73122 and 2-APB , while Calphostin C suppressed it to a small extent and PD98059 was ineffective . Positive_regulation MUC16 UTP20 16139976 1475406 *induced* [mucin] secretion in NHMEE cells is strongly dependent on Ca ( 2+ ) - and IP ( 3 ) . Positive_regulation MUC16 UTP20 17250694 1690872 As *stimulates* both [mucin] secretion and Cl ion transport via a Ca ( 2+ ) -dependent pathway , the purpose of this study is to determine whether IL-9 and IL-13 affect UTP induced Cl ion transport in human bronchial epithelial cell line 16HBE cells , and if they do , to elucidate whether such an effect is associated with hCLCA1 expression . Positive_regulation MUC16 UTP23 11694445 876690 However , only can *increase* [mucin] gene ( MUC5AC , MUC5B ) expression ; Positive_regulation MUC16 UTP23 11694445 876972 These findings are the first demonstration that , a pyrimidine nucleotide triphosphate , can *enhance* both mucin secretion and [mucin] gene expression through different signaling pathways . Positive_regulation MUC16 UTP23 12737291 1087611 Extracellular *regulates* a variety of biological functions in the airway epithelium , including chloride and fluid transport , mucociliary clearance and [mucin] secretion via the P2Y purinergic receptors . Positive_regulation MUC16 UTP23 12737291 1087795 In contrast , did not *enhance* [mucin] and lysozyme mRNA expression until 72 h after treatment . Positive_regulation MUC16 UTP23 14710912 1181500 and ATPgammaS increased [ Ca2+ ] i via caffeine-sensitive pathways , and these two agonists *stimulated* [mucin] secretion to a similar magnitude without their gene enhancement . Positive_regulation MUC16 UTP23 16139976 1475126 *induced* [mucin] secretion was quantified by an immunoblotting assay . Positive_regulation MUC16 UTP23 16139976 1475216 *induced* [mucin] secretion was inhibited by a Ca ( 2+ ) chelating agent , BAPTA-AM , and was stimulated by ionomycin . Positive_regulation MUC16 UTP23 16139976 1475321 *induced* [mucin] secretion was also suppressed by U73122 and 2-APB , while Calphostin C suppressed it to a small extent and PD98059 was ineffective . Positive_regulation MUC16 UTP23 16139976 1475411 *induced* [mucin] secretion in NHMEE cells is strongly dependent on Ca ( 2+ ) - and IP ( 3 ) . Positive_regulation MUC16 UTP23 17250694 1690877 As *stimulates* both [mucin] secretion and Cl ion transport via a Ca ( 2+ ) -dependent pathway , the purpose of this study is to determine whether IL-9 and IL-13 affect UTP induced Cl ion transport in human bronchial epithelial cell line 16HBE cells , and if they do , to elucidate whether such an effect is associated with hCLCA1 expression . Positive_regulation MUC16 UTP3 11694445 876688 However , only can *increase* [mucin] gene ( MUC5AC , MUC5B ) expression ; Positive_regulation MUC16 UTP3 11694445 876970 These findings are the first demonstration that , a pyrimidine nucleotide triphosphate , can *enhance* both mucin secretion and [mucin] gene expression through different signaling pathways . Positive_regulation MUC16 UTP3 12737291 1087609 Extracellular *regulates* a variety of biological functions in the airway epithelium , including chloride and fluid transport , mucociliary clearance and [mucin] secretion via the P2Y purinergic receptors . Positive_regulation MUC16 UTP3 12737291 1087793 In contrast , did not *enhance* [mucin] and lysozyme mRNA expression until 72 h after treatment . Positive_regulation MUC16 UTP3 14710912 1181498 and ATPgammaS increased [ Ca2+ ] i via caffeine-sensitive pathways , and these two agonists *stimulated* [mucin] secretion to a similar magnitude without their gene enhancement . Positive_regulation MUC16 UTP3 16139976 1475124 *induced* [mucin] secretion was quantified by an immunoblotting assay . Positive_regulation MUC16 UTP3 16139976 1475214 *induced* [mucin] secretion was inhibited by a Ca ( 2+ ) chelating agent , BAPTA-AM , and was stimulated by ionomycin . Positive_regulation MUC16 UTP3 16139976 1475319 *induced* [mucin] secretion was also suppressed by U73122 and 2-APB , while Calphostin C suppressed it to a small extent and PD98059 was ineffective . Positive_regulation MUC16 UTP3 16139976 1475409 *induced* [mucin] secretion in NHMEE cells is strongly dependent on Ca ( 2+ ) - and IP ( 3 ) . Positive_regulation MUC16 UTP3 17250694 1690875 As *stimulates* both [mucin] secretion and Cl ion transport via a Ca ( 2+ ) -dependent pathway , the purpose of this study is to determine whether IL-9 and IL-13 affect UTP induced Cl ion transport in human bronchial epithelial cell line 16HBE cells , and if they do , to elucidate whether such an effect is associated with hCLCA1 expression . Positive_regulation MUC16 UTP6 11694445 876686 However , only can *increase* [mucin] gene ( MUC5AC , MUC5B ) expression ; Positive_regulation MUC16 UTP6 11694445 876968 These findings are the first demonstration that , a pyrimidine nucleotide triphosphate , can *enhance* both mucin secretion and [mucin] gene expression through different signaling pathways . Positive_regulation MUC16 UTP6 12737291 1087607 Extracellular *regulates* a variety of biological functions in the airway epithelium , including chloride and fluid transport , mucociliary clearance and [mucin] secretion via the P2Y purinergic receptors . Positive_regulation MUC16 UTP6 12737291 1087791 In contrast , did not *enhance* [mucin] and lysozyme mRNA expression until 72 h after treatment . Positive_regulation MUC16 UTP6 14710912 1181496 and ATPgammaS increased [ Ca2+ ] i via caffeine-sensitive pathways , and these two agonists *stimulated* [mucin] secretion to a similar magnitude without their gene enhancement . Positive_regulation MUC16 UTP6 16139976 1475122 *induced* [mucin] secretion was quantified by an immunoblotting assay . Positive_regulation MUC16 UTP6 16139976 1475212 *induced* [mucin] secretion was inhibited by a Ca ( 2+ ) chelating agent , BAPTA-AM , and was stimulated by ionomycin . Positive_regulation MUC16 UTP6 16139976 1475317 *induced* [mucin] secretion was also suppressed by U73122 and 2-APB , while Calphostin C suppressed it to a small extent and PD98059 was ineffective . Positive_regulation MUC16 UTP6 16139976 1475407 *induced* [mucin] secretion in NHMEE cells is strongly dependent on Ca ( 2+ ) - and IP ( 3 ) . Positive_regulation MUC16 UTP6 17250694 1690873 As *stimulates* both [mucin] secretion and Cl ion transport via a Ca ( 2+ ) -dependent pathway , the purpose of this study is to determine whether IL-9 and IL-13 affect UTP induced Cl ion transport in human bronchial epithelial cell line 16HBE cells , and if they do , to elucidate whether such an effect is associated with hCLCA1 expression . Positive_regulation MUC16 VIP 12056823 951938 Secretion of MUC5AC [mucin] from pancreatic cancer cells in *response* to forskolin and . Positive_regulation MUC16 VIP 16227528 1469747 *upregulates* MUC2 intestinal [mucin] via CREB/ATF1 . Positive_regulation MUC16 VIP 16645189 1583333 VIP ( 10 ( -7 ) M ) increased mucin secretion over 2 h . ( 10 ( -9 ) to 10 ( -5 ) M ) *stimulated* [mucin] secretion in a dose dependent fashion . Positive_regulation MUC16 VIP 16645189 1583348 *induced* [mucin] secretion was partially blocked by a VIP receptor antagonist ( a chimeric VIP-pituitary adenylate cyclase activating peptide analog , VIP receptor antagonist ) at a 10-fold excess concentration . Positive_regulation MUC16 VIP 16645189 1583363 We conclude that *stimulated* [mucin] and lysozyme secretion was both time dependent and dose dependent and that NO neither stimulates nor inhibits mucus secretion in the ferret trachea . Positive_regulation MUC16 VIP 2160804 133368 The ED50 for *stimulated* [mucin] release was 0.12 +/- 0.05 nM , thus suggesting an activation anomaly in the vasoactive intestinal peptide receptor coupled signal transduction pathway at a point between cyclic AMP production and mucin release . Positive_regulation MUC16 VIP 2538074 108252 However , strongly *potentiated* carbachol induced [mucin] secretion , since carbachol alone and VIP plus carbachol induced a 1.6- and 3.6-fold increase of mucin secretion above basal , respectively . Positive_regulation MUC16 VIP 2544928 114126 This is the first report of *induced* [mucin] secretion in colon tumor cells . Positive_regulation MUC16 VIP 8655762 364696 We isolated sublingual mucous acini from five-month-old and 24-month-old rats and compared the concentration responses for [mucin] secretion *induced* by and the muscarinic agonist , arecaidine propargyl ester (APE) . Positive_regulation MUC16 VIP 9815038 546483 *stimulated* [mucin] secretion was abolished by tetrodotoxin , whereas atropine was without effect . Positive_regulation MUC16 WDR61 1540379 180751 Both NDGA and BPB blocked *stimulated* [mucin] release in a concentration dependent manner . Positive_regulation MUC16 WDR61 3653044 78295 These results are consistent with the hypothesis that *stimulates* secretion of [mucin] by activating biosynthesis of lipoxygenase products ( e.g. , peptidyl leukotrienes ) within epithelial cells of the respiratory mucosa . Positive_regulation MUC16 WDR61 8049080 267201 This study assessed the role of protein kinase C ( PKC ) in *induced* [mucin] release from primary cultures of feline tracheal epithelial cells ( FTEC ) . Positive_regulation MUC16 WDR61 8049080 267276 Coincubation of FTEC with PAF ( 5 microM ) and pharmacologic PKC inhibitors , sphingosine , H7 , or calphostin C , inhibited *induced* [mucin] secretion at 30 min . Positive_regulation MUC16 WDR61 8049080 267351 Determination of the specific PKC isozyme ( s ) involved in *induced* [mucin] release was performed by immunoblot analysis of the subcellular fractions using a battery of antibodies against various PKC isozymes ( anti-PKC alpha , beta , delta , gamma , epsilon , and zeta ) . Positive_regulation MUC16 WDR61 9552223 492387 In HT-29 cells , MMS-68 plus leukotriene C4 ( LTC4 ) induced a 50 % increase in [mucin] release over either secretagogue alone , and MMS-68 plus markedly *enhanced* mucin release by eightfold over either secretagogue . Positive_regulation MUC16 WDR61 9620929 510664 In this study , we examined the hypothesis that *induces* goblet cell hyperplasia and [mucin] gene expression . Positive_regulation MUC16 WDR61 9620929 510739 In rat tracheas studied by in situ hybridization , *induced* [mucin] MUC5 gene expression in epithelial cells that stained for mucosubstances . Positive_regulation MUC16 WFDC2 22962406 2693430 [CA125] was lower in women age =55 , and *increased* with age ( P < 0.01 ) , particularly among women age =55 . Positive_regulation MUC16 XBP1 23168839 2769036 IRE1ß dependent [mucin] production is *mediated* , at least in part , by activation of the transcription factor and the resulting XBP-1 dependent transcription of anterior gradient homolog 2 , a gene implicated in airway and intestinal epithelial mucin production . Positive_regulation MUC17 EPHB2 17237423 1690002 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Positive_regulation MUC17 GPR115 15527548 1329935 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC17 GPR132 15527548 1329924 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC17 GPR87 15527548 1330004 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC17 IL1B 12391274 1007520 These results suggest a role for PGE ( 2 ) in *induced* [mucin] synthesis in NCI-H292 cells . Positive_regulation MUC17 IL1B 12391274 1007538 Furthermore , the addition of PGE ( 2 ) to cells overcame the inhibitory effects of both MAPK inhibitors in *induced* [mucin] production . Positive_regulation MUC17 IL1B 12482999 1024556 *induces* MUC2 gene expression and [mucin] secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation MUC17 IL1B 12482999 1024587 In cultured human airway NCI-H292 epithelial cells , the steady state of the mRNA level of MUC2 gene expression and [mucin] secretion *induced* by were determined by reverse transcriptase-polymerase chain reaction ( RT-PCR ) , enzyme immunoassay , and immunoblot analysis . Positive_regulation MUC17 IL1B 12482999 1024602 PD98059 ( MEK/ERK inhibitor ) suppressed *mediated* MUC2 gene expression and [mucin] secretion , while SB203580 ( p38 inhibitor ) did not . Positive_regulation MUC17 IL1B 12482999 1024617 Ro31-8220 ( PKC inhibitor ) inhibited *mediated* MUC2 gene expression and [mucin] secretion . Positive_regulation MUC17 IL1B 12869928 1112243 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Positive_regulation MUC17 IL1B 12869928 1112273 *upregulates* [mucin] secretion from cultured middle ear epithelial cells in a dose- and time dependent manner . Positive_regulation MUC17 IL1B 15266025 1275874 *induced* [mucin] production in human airway epithelium is mediated by cyclooxygenase-2 , prostaglandin E2 receptors , and cyclic AMP-protein kinase A signaling . Positive_regulation MUC17 IL1B 15668323 1382120 increased the thickness of conducting airways , *enhanced* [mucin] production , and caused lymphocytic aggregates in the airways . Positive_regulation MUC17 IL1B 16467705 1523529 Signaling pathways in *mediated* middle ear [mucin] secretion . Positive_regulation MUC17 IL1B 16467705 1523589 *stimulates* [mucin] secretion from middle ear epithelium and its effects can be reversed by IL-1betara . Positive_regulation MUC17 IL1B 20873538 2326424 These results suggest that may *enhance* [mucin] gene expression in cultured human nasal epithelial cells . Positive_regulation MUC17 RARB 10024510 590849 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Positive_regulation MUC17 SPHK1 19835973 2203012 *regulates* [mucin] production via ERK phosphorylation . Positive_regulation MUC17 SPHK1 19835973 2203075 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Positive_regulation MUC17 TNF 10030839 591792 *stimulates* [mucin] secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro . Positive_regulation MUC17 TNF 10030839 591807 In this study , we investigated potential signaling pathways mediating *induced* [mucin] secretion using guinea pig tracheal epithelial ( GPTE ) cells in air-liquid interface culture . Positive_regulation MUC17 TNF 10030839 591822 Exogenously applied ( human recombinant ) *stimulated* [mucin] secretion in a concentration dependent manner , with maximal effects at 10 to 15 ng/ml ( 286 to 429 U/ml ) . Positive_regulation MUC17 TNF 10030839 591837 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Positive_regulation MUC17 TNF 10030839 591869 Collectively , the results suggest that *stimulates* secretion of [mucin] by GPTE cells via a mechanism ( s ) dependent on PC-PLC and PKC , and involving activation of NOS , generation of NO , production of cGMP , and activation of PKG . Positive_regulation MUC17 TNF 10950784 723460 *Induction* of [mucin] gene expression in middle ear of rats by : potential cause for mucoid otitis media . Positive_regulation MUC17 TNF 11052828 743486 *stimulates* MUC5AC [mucin] secretion in a dose dependent manner , with 20 ng/ml producing maximal stimulation . Positive_regulation MUC17 TNF 11282555 799135 IL-6 and *stimulated* MUC5AC and MUC5B [mucin] secretion in a time dependent manner , both in pre-confluent and post-confluent cells . Positive_regulation MUC17 TNF 12018326 942420 Recent studies demonstrated that , present in human middle ear effusion , *stimulated* [mucin] production in vitro and up-regulated mucin gene expression in vivo . Positive_regulation MUC17 TNF 15696080 1372027 Niflumic acid and MSI-2216 reduce *induced* [mucin] expression in human airway mucosa . Positive_regulation MUC17 TNF 15696080 1372044 Unstimulated and *induced* [mucin] expression could be decreased by NFA and MSI-2216 . Positive_regulation MUC17 TNF 16543607 1582107 We demonstrated that cigarette smoke extract (CSE) synergistically increased gene expression and protein production of MUC5AC [mucin] *induced* by LPS or in human airway epithelial NCI-H292 cells . Positive_regulation MUC17 TNF 19053887 2017602 Both LPS and *increased* MUC5AC [mucin] production in vivo and in vitro , respectively , and fudosteine was found to reduce it by partially interfering with the kinase mediated inflammation pathway that activates the MUC5AC gene . Positive_regulation MUC17 TNF 23463646 2895467 Inhibition of *induced* MUC5AC [mucin] gene expression and production by wogonin through the inactivation of NF-?B signaling in airway epithelial cells . Positive_regulation MUC17 TNF 24348668 2881122 We investigated whether prunetin significantly affects *induced* MUC5AC [mucin] gene expression , production , inhibitory kappa B ( I?B ) degradation and nuclear factor kappa B ( NF-?B ) p65 translocation in human airway epithelial cells . Positive_regulation MUC19 EPHB2 17237423 1689996 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Positive_regulation MUC19 GPR115 15527548 1329656 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC19 GPR132 15527548 1329645 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC19 GPR87 15527548 1329725 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC19 IL1B 12391274 1007517 These results suggest a role for PGE ( 2 ) in *induced* [mucin] synthesis in NCI-H292 cells . Positive_regulation MUC19 IL1B 12391274 1007535 Furthermore , the addition of PGE ( 2 ) to cells overcame the inhibitory effects of both MAPK inhibitors in *induced* [mucin] production . Positive_regulation MUC19 IL1B 12482999 1024553 *induces* MUC2 gene expression and [mucin] secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation MUC19 IL1B 12482999 1024584 In cultured human airway NCI-H292 epithelial cells , the steady state of the mRNA level of MUC2 gene expression and [mucin] secretion *induced* by were determined by reverse transcriptase-polymerase chain reaction ( RT-PCR ) , enzyme immunoassay , and immunoblot analysis . Positive_regulation MUC19 IL1B 12482999 1024599 PD98059 ( MEK/ERK inhibitor ) suppressed *mediated* MUC2 gene expression and [mucin] secretion , while SB203580 ( p38 inhibitor ) did not . Positive_regulation MUC19 IL1B 12482999 1024614 Ro31-8220 ( PKC inhibitor ) inhibited *mediated* MUC2 gene expression and [mucin] secretion . Positive_regulation MUC19 IL1B 12869928 1112240 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Positive_regulation MUC19 IL1B 12869928 1112270 *upregulates* [mucin] secretion from cultured middle ear epithelial cells in a dose- and time dependent manner . Positive_regulation MUC19 IL1B 15266025 1275868 *induced* [mucin] production in human airway epithelium is mediated by cyclooxygenase-2 , prostaglandin E2 receptors , and cyclic AMP-protein kinase A signaling . Positive_regulation MUC19 IL1B 15668323 1382117 increased the thickness of conducting airways , *enhanced* [mucin] production , and caused lymphocytic aggregates in the airways . Positive_regulation MUC19 IL1B 16467705 1523526 Signaling pathways in *mediated* middle ear [mucin] secretion . Positive_regulation MUC19 IL1B 16467705 1523586 *stimulates* [mucin] secretion from middle ear epithelium and its effects can be reversed by IL-1betara . Positive_regulation MUC19 IL1B 20873538 2326421 These results suggest that may *enhance* [mucin] gene expression in cultured human nasal epithelial cells . Positive_regulation MUC19 RARB 10024510 590846 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Positive_regulation MUC19 SPHK1 19835973 2203009 *regulates* [mucin] production via ERK phosphorylation . Positive_regulation MUC19 SPHK1 19835973 2203069 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Positive_regulation MUC19 TNF 10030839 591789 *stimulates* [mucin] secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro . Positive_regulation MUC19 TNF 10030839 591804 In this study , we investigated potential signaling pathways mediating *induced* [mucin] secretion using guinea pig tracheal epithelial ( GPTE ) cells in air-liquid interface culture . Positive_regulation MUC19 TNF 10030839 591819 Exogenously applied ( human recombinant ) *stimulated* [mucin] secretion in a concentration dependent manner , with maximal effects at 10 to 15 ng/ml ( 286 to 429 U/ml ) . Positive_regulation MUC19 TNF 10030839 591834 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Positive_regulation MUC19 TNF 10030839 591866 Collectively , the results suggest that *stimulates* secretion of [mucin] by GPTE cells via a mechanism ( s ) dependent on PC-PLC and PKC , and involving activation of NOS , generation of NO , production of cGMP , and activation of PKG . Positive_regulation MUC19 TNF 10950784 723457 *Induction* of [mucin] gene expression in middle ear of rats by : potential cause for mucoid otitis media . Positive_regulation MUC19 TNF 11052828 743483 *stimulates* MUC5AC [mucin] secretion in a dose dependent manner , with 20 ng/ml producing maximal stimulation . Positive_regulation MUC19 TNF 11282555 799129 IL-6 and *stimulated* MUC5AC and MUC5B [mucin] secretion in a time dependent manner , both in pre-confluent and post-confluent cells . Positive_regulation MUC19 TNF 12018326 942417 Recent studies demonstrated that , present in human middle ear effusion , *stimulated* mucin production in vitro and up-regulated [mucin] gene expression in vivo . Positive_regulation MUC19 TNF 15696080 1372024 Niflumic acid and MSI-2216 reduce *induced* [mucin] expression in human airway mucosa . Positive_regulation MUC19 TNF 15696080 1372041 Unstimulated and *induced* [mucin] expression could be decreased by NFA and MSI-2216 . Positive_regulation MUC19 TNF 16543607 1582101 We demonstrated that cigarette smoke extract (CSE) synergistically increased gene expression and protein production of MUC5AC [mucin] *induced* by LPS or in human airway epithelial NCI-H292 cells . Positive_regulation MUC19 TNF 19053887 2017599 Both LPS and *increased* MUC5AC [mucin] production in vivo and in vitro , respectively , and fudosteine was found to reduce it by partially interfering with the kinase mediated inflammation pathway that activates the MUC5AC gene . Positive_regulation MUC19 TNF 23463646 2895464 Inhibition of *induced* MUC5AC [mucin] gene expression and production by wogonin through the inactivation of NF-?B signaling in airway epithelial cells . Positive_regulation MUC19 TNF 24348668 2881119 We investigated whether prunetin significantly affects *induced* MUC5AC [mucin] gene expression , production , inhibitory kappa B ( I?B ) degradation and nuclear factor kappa B ( NF-?B ) p65 translocation in human airway epithelial cells . Positive_regulation MUC2 AGR2 22403803 2636747 The endoplasmic reticulum (ER) protein is *required* for production of the intestinal mucin [MUC2] , but its role in the production of the airway mucins MUC5AC and MUC5B is not established . Positive_regulation MUC2 EPHB2 17237423 1690016 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Positive_regulation MUC2 FOXA1 19737569 2168230 In vitro studies have shown that can *transactivate* the promoters of [Mucin 2 (Muc2)] , which is expressed in goblet cells , and of preproglucagon , which is expressed in enteroendocrine cells . Positive_regulation MUC2 GPR115 15527548 1330587 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC2 GPR132 15527548 1330576 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC2 GPR87 15527548 1330656 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC2 IL1B 10903904 713418 The expression level of [MUC2] *induced* by increased in a dose dependent manner . Positive_regulation MUC2 IL1B 10903904 713419 MUC2 transcripts were detected after 2 h of exposure to IL-1beta and reached maximal level after 8 h. Actinomycin D experiments indicated that the *mediated* [MUC2] expression was controlled by transcriptional regulation . Positive_regulation MUC2 IL1B 12391274 1007515 *induces* [MUC2] and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells . Positive_regulation MUC2 IL1B 12391274 1007527 These results suggest a role for PGE ( 2 ) in *induced* [mucin] synthesis in NCI-H292 cells . Positive_regulation MUC2 IL1B 12391274 1007532 Cells activated by IL-1beta showed increased extracellular signal regulated kinase ( ERK ) 1/2 and p38 phosphorylation , and *induced* [MUC2] and MUC5AC production was blocked by the ERK pathway inhibitor PD98059 or the p38 inhibitor SB203580 . Positive_regulation MUC2 IL1B 12391274 1007545 Furthermore , the addition of PGE ( 2 ) to cells overcame the inhibitory effects of both MAPK inhibitors in *induced* [mucin] production . Positive_regulation MUC2 IL1B 12482999 1024578 *induces* [MUC2] gene expression and mucin secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation MUC2 IL1B 12482999 1024594 In cultured human airway NCI-H292 epithelial cells , the steady state of the mRNA level of MUC2 gene expression and [mucin] secretion *induced* by were determined by reverse transcriptase-polymerase chain reaction ( RT-PCR ) , enzyme immunoassay , and immunoblot analysis . Positive_regulation MUC2 IL1B 12482999 1024609 PD98059 ( MEK/ERK inhibitor ) suppressed *mediated* [MUC2] gene expression and mucin secretion , while SB203580 ( p38 inhibitor ) did not . Positive_regulation MUC2 IL1B 12482999 1024624 Ro31-8220 ( PKC inhibitor ) inhibited *mediated* [MUC2] gene expression and mucin secretion . Positive_regulation MUC2 IL1B 12482999 1024638 These results suggest that the mediated MUC2 gene expression and mucin secretion in NCI-H292 cells are regulated through activation of the PKC-MEK/ERK pathway , and that PI3K is also *involved* in the IL-1beta mediated [MUC2] gene expression and mucin secretion . Positive_regulation MUC2 IL1B 12869928 1112250 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Positive_regulation MUC2 IL1B 12869928 1112280 *upregulates* [mucin] secretion from cultured middle ear epithelial cells in a dose- and time dependent manner . Positive_regulation MUC2 IL1B 15266025 1275888 *induced* [mucin] production in human airway epithelium is mediated by cyclooxygenase-2 , prostaglandin E2 receptors , and cyclic AMP-protein kinase A signaling . Positive_regulation MUC2 IL1B 15668323 1382127 increased the thickness of conducting airways , *enhanced* [mucin] production , and caused lymphocytic aggregates in the airways . Positive_regulation MUC2 IL1B 16467705 1523536 Signaling pathways in *mediated* middle ear [mucin] secretion . Positive_regulation MUC2 IL1B 16467705 1523596 *stimulates* [mucin] secretion from middle ear epithelium and its effects can be reversed by IL-1betara . Positive_regulation MUC2 IL1B 20062084 2225438 These differences can be attributed to specific cytokines , because TNF-alpha and *induced* [MUC2] but no MUC4 expression in gastric cancer cell lines . Positive_regulation MUC2 IL1B 20873538 2326419 *increased* [MUC2/MUC5B] mRNA levels in human nasal epithelial cells . Positive_regulation MUC2 IL1B 20873538 2326431 These results suggest that may *enhance* [mucin] gene expression in cultured human nasal epithelial cells . Positive_regulation MUC2 MAP2K6 17374366 1720598 Butyrate stimulated [MUC2] production in the LS174T cells was *inhibited* by the inhibitor , U0126 , implicating the involvement of extracellular signal regulated kinase ( ERK ) cascades in this process . Positive_regulation MUC2 MUC16 12482999 1024633 These results suggest that the IL-1beta mediated MUC2 gene expression and secretion in NCI-H292 cells are regulated through activation of the PKC-MEK/ERK pathway , and that PI3K is also *involved* in the IL-1beta mediated [MUC2] gene expression and mucin secretion . Positive_regulation MUC2 RARB 10024510 590856 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Positive_regulation MUC2 SPHK1 19835973 2203019 *regulates* [mucin] production via ERK phosphorylation . Positive_regulation MUC2 SPHK1 19835973 2203089 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Positive_regulation MUC2 TNF 10030839 591799 *stimulates* [mucin] secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro . Positive_regulation MUC2 TNF 10030839 591814 In this study , we investigated potential signaling pathways mediating *induced* [mucin] secretion using guinea pig tracheal epithelial ( GPTE ) cells in air-liquid interface culture . Positive_regulation MUC2 TNF 10030839 591829 Exogenously applied ( human recombinant ) *stimulated* [mucin] secretion in a concentration dependent manner , with maximal effects at 10 to 15 ng/ml ( 286 to 429 U/ml ) . Positive_regulation MUC2 TNF 10030839 591844 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Positive_regulation MUC2 TNF 10030839 591876 Collectively , the results suggest that *stimulates* secretion of [mucin] by GPTE cells via a mechanism ( s ) dependent on PC-PLC and PKC , and involving activation of NOS , generation of NO , production of cGMP , and activation of PKG . Positive_regulation MUC2 TNF 10950784 723467 *Induction* of [mucin] gene expression in middle ear of rats by : potential cause for mucoid otitis media . Positive_regulation MUC2 TNF 11052828 743493 *stimulates* MUC5AC [mucin] secretion in a dose dependent manner , with 20 ng/ml producing maximal stimulation . Positive_regulation MUC2 TNF 11282555 799149 IL-6 and *stimulated* MUC5AC and MUC5B [mucin] secretion in a time dependent manner , both in pre-confluent and post-confluent cells . Positive_regulation MUC2 TNF 12018326 942427 Recent studies demonstrated that , present in human middle ear effusion , *stimulated* mucin production in vitro and up-regulated [mucin] gene expression in vivo . Positive_regulation MUC2 TNF 15665513 1365430 *activates* [MUC2] transcription via NF-kappaB but inhibits via JNK activation . Positive_regulation MUC2 TNF 15665513 1365446 Thus *causes* a net up-regulation of [MUC2] gene expression in cultured colon cancer cells because NF-kappaB transcriptional activation of this gene is able to counter-balance the suppressive effects of the JNK pathway . Positive_regulation MUC2 TNF 15665513 1365447 However , the existence of this inhibitory JNK pathways suggests a mechanism whereby -- in the absence of NF-kappaB activation -- production during inflammation in vivo could actually *inhibit* [MUC2] production , giving rise to the defective mucosal protection which characterizes inflammatory bowel disease . Positive_regulation MUC2 TNF 15696080 1372034 Niflumic acid and MSI-2216 reduce *induced* [mucin] expression in human airway mucosa . Positive_regulation MUC2 TNF 15696080 1372051 Unstimulated and *induced* [mucin] expression could be decreased by NFA and MSI-2216 . Positive_regulation MUC2 TNF 16543607 1582121 We demonstrated that cigarette smoke extract (CSE) synergistically increased gene expression and protein production of MUC5AC [mucin] *induced* by LPS or in human airway epithelial NCI-H292 cells . Positive_regulation MUC2 TNF 18507686 1958433 *induced* the expression of CDX2 and [MUC2] in cultured BEC . Positive_regulation MUC2 TNF 19053887 2017609 Both LPS and *increased* MUC5AC [mucin] production in vivo and in vitro , respectively , and fudosteine was found to reduce it by partially interfering with the kinase mediated inflammation pathway that activates the MUC5AC gene . Positive_regulation MUC2 TNF 20062084 2225437 These differences can be attributed to specific cytokines , because and IL-1beta *induced* [MUC2] but no MUC4 expression in gastric cancer cell lines . Positive_regulation MUC2 TNF 21737776 2484155 caused a loss of mucus containing goblet cells only in immature mice and *induced* [Muc2] and Muc3 mRNA upregulation only in mature ileum . Positive_regulation MUC2 TNF 22101519 2514311 Flagellin , IL-13 and all significantly *increased* GAL3ST2 , [MUC2] , TFF3 and TLR5 expression , while only IL-13 increased RETNLB and CHST5 expression . Positive_regulation MUC2 TNF 23463646 2895474 Inhibition of *induced* MUC5AC [mucin] gene expression and production by wogonin through the inactivation of NF-?B signaling in airway epithelial cells . Positive_regulation MUC2 TNF 24348668 2881129 We investigated whether prunetin significantly affects *induced* MUC5AC [mucin] gene expression , production , inhibitory kappa B ( I?B ) degradation and nuclear factor kappa B ( NF-?B ) p65 translocation in human airway epithelial cells . Positive_regulation MUC20 EPHB2 17237423 1690006 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Positive_regulation MUC20 GPR115 15527548 1330121 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC20 GPR132 15527548 1330110 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC20 GPR87 15527548 1330190 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC20 IL1B 12391274 1007522 These results suggest a role for PGE ( 2 ) in *induced* [mucin] synthesis in NCI-H292 cells . Positive_regulation MUC20 IL1B 12391274 1007540 Furthermore , the addition of PGE ( 2 ) to cells overcame the inhibitory effects of both MAPK inhibitors in *induced* [mucin] production . Positive_regulation MUC20 IL1B 12482999 1024558 *induces* MUC2 gene expression and [mucin] secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation MUC20 IL1B 12482999 1024589 In cultured human airway NCI-H292 epithelial cells , the steady state of the mRNA level of MUC2 gene expression and [mucin] secretion *induced* by were determined by reverse transcriptase-polymerase chain reaction ( RT-PCR ) , enzyme immunoassay , and immunoblot analysis . Positive_regulation MUC20 IL1B 12482999 1024604 PD98059 ( MEK/ERK inhibitor ) suppressed *mediated* MUC2 gene expression and [mucin] secretion , while SB203580 ( p38 inhibitor ) did not . Positive_regulation MUC20 IL1B 12482999 1024619 Ro31-8220 ( PKC inhibitor ) inhibited *mediated* MUC2 gene expression and [mucin] secretion . Positive_regulation MUC20 IL1B 12869928 1112245 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Positive_regulation MUC20 IL1B 12869928 1112275 *upregulates* [mucin] secretion from cultured middle ear epithelial cells in a dose- and time dependent manner . Positive_regulation MUC20 IL1B 15266025 1275878 *induced* [mucin] production in human airway epithelium is mediated by cyclooxygenase-2 , prostaglandin E2 receptors , and cyclic AMP-protein kinase A signaling . Positive_regulation MUC20 IL1B 15668323 1382122 increased the thickness of conducting airways , *enhanced* [mucin] production , and caused lymphocytic aggregates in the airways . Positive_regulation MUC20 IL1B 16467705 1523531 Signaling pathways in *mediated* middle ear [mucin] secretion . Positive_regulation MUC20 IL1B 16467705 1523591 *stimulates* [mucin] secretion from middle ear epithelium and its effects can be reversed by IL-1betara . Positive_regulation MUC20 IL1B 20873538 2326426 These results suggest that may *enhance* [mucin] gene expression in cultured human nasal epithelial cells . Positive_regulation MUC20 RARB 10024510 590851 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Positive_regulation MUC20 SPHK1 19835973 2203014 *regulates* [mucin] production via ERK phosphorylation . Positive_regulation MUC20 SPHK1 19835973 2203079 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Positive_regulation MUC20 TNF 10030839 591794 *stimulates* [mucin] secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro . Positive_regulation MUC20 TNF 10030839 591809 In this study , we investigated potential signaling pathways mediating *induced* [mucin] secretion using guinea pig tracheal epithelial ( GPTE ) cells in air-liquid interface culture . Positive_regulation MUC20 TNF 10030839 591824 Exogenously applied ( human recombinant ) *stimulated* [mucin] secretion in a concentration dependent manner , with maximal effects at 10 to 15 ng/ml ( 286 to 429 U/ml ) . Positive_regulation MUC20 TNF 10030839 591839 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Positive_regulation MUC20 TNF 10030839 591871 Collectively , the results suggest that *stimulates* secretion of [mucin] by GPTE cells via a mechanism ( s ) dependent on PC-PLC and PKC , and involving activation of NOS , generation of NO , production of cGMP , and activation of PKG . Positive_regulation MUC20 TNF 10950784 723462 *Induction* of [mucin] gene expression in middle ear of rats by : potential cause for mucoid otitis media . Positive_regulation MUC20 TNF 11052828 743488 *stimulates* MUC5AC [mucin] secretion in a dose dependent manner , with 20 ng/ml producing maximal stimulation . Positive_regulation MUC20 TNF 11282555 799139 IL-6 and *stimulated* MUC5AC and MUC5B [mucin] secretion in a time dependent manner , both in pre-confluent and post-confluent cells . Positive_regulation MUC20 TNF 12018326 942422 Recent studies demonstrated that , present in human middle ear effusion , *stimulated* [mucin] production in vitro and up-regulated mucin gene expression in vivo . Positive_regulation MUC20 TNF 15696080 1372029 Niflumic acid and MSI-2216 reduce *induced* [mucin] expression in human airway mucosa . Positive_regulation MUC20 TNF 15696080 1372046 Unstimulated and *induced* [mucin] expression could be decreased by NFA and MSI-2216 . Positive_regulation MUC20 TNF 16543607 1582111 We demonstrated that cigarette smoke extract (CSE) synergistically increased gene expression and protein production of MUC5AC [mucin] *induced* by LPS or in human airway epithelial NCI-H292 cells . Positive_regulation MUC20 TNF 19053887 2017604 Both LPS and *increased* MUC5AC [mucin] production in vivo and in vitro , respectively , and fudosteine was found to reduce it by partially interfering with the kinase mediated inflammation pathway that activates the MUC5AC gene . Positive_regulation MUC20 TNF 23463646 2895469 Inhibition of *induced* MUC5AC [mucin] gene expression and production by wogonin through the inactivation of NF-?B signaling in airway epithelial cells . Positive_regulation MUC20 TNF 24348668 2881124 We investigated whether prunetin significantly affects *induced* MUC5AC [mucin] gene expression , production , inhibitory kappa B ( I?B ) degradation and nuclear factor kappa B ( NF-?B ) p65 translocation in human airway epithelial cells . Positive_regulation MUC21 EPHB2 17237423 1690004 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Positive_regulation MUC21 GPR115 15527548 1330028 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC21 GPR132 15527548 1330017 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC21 GPR87 15527548 1330097 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC21 IL1B 12391274 1007521 These results suggest a role for PGE ( 2 ) in *induced* [mucin] synthesis in NCI-H292 cells . Positive_regulation MUC21 IL1B 12391274 1007539 Furthermore , the addition of PGE ( 2 ) to cells overcame the inhibitory effects of both MAPK inhibitors in *induced* [mucin] production . Positive_regulation MUC21 IL1B 12482999 1024557 *induces* MUC2 gene expression and [mucin] secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation MUC21 IL1B 12482999 1024588 In cultured human airway NCI-H292 epithelial cells , the steady state of the mRNA level of MUC2 gene expression and [mucin] secretion *induced* by were determined by reverse transcriptase-polymerase chain reaction ( RT-PCR ) , enzyme immunoassay , and immunoblot analysis . Positive_regulation MUC21 IL1B 12482999 1024603 PD98059 ( MEK/ERK inhibitor ) suppressed *mediated* MUC2 gene expression and [mucin] secretion , while SB203580 ( p38 inhibitor ) did not . Positive_regulation MUC21 IL1B 12482999 1024618 Ro31-8220 ( PKC inhibitor ) inhibited *mediated* MUC2 gene expression and [mucin] secretion . Positive_regulation MUC21 IL1B 12869928 1112244 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Positive_regulation MUC21 IL1B 12869928 1112274 *upregulates* [mucin] secretion from cultured middle ear epithelial cells in a dose- and time dependent manner . Positive_regulation MUC21 IL1B 15266025 1275876 *induced* [mucin] production in human airway epithelium is mediated by cyclooxygenase-2 , prostaglandin E2 receptors , and cyclic AMP-protein kinase A signaling . Positive_regulation MUC21 IL1B 15668323 1382121 increased the thickness of conducting airways , *enhanced* [mucin] production , and caused lymphocytic aggregates in the airways . Positive_regulation MUC21 IL1B 16467705 1523530 Signaling pathways in *mediated* middle ear [mucin] secretion . Positive_regulation MUC21 IL1B 16467705 1523590 *stimulates* [mucin] secretion from middle ear epithelium and its effects can be reversed by IL-1betara . Positive_regulation MUC21 IL1B 20873538 2326425 These results suggest that may *enhance* [mucin] gene expression in cultured human nasal epithelial cells . Positive_regulation MUC21 RARB 10024510 590850 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Positive_regulation MUC21 SPHK1 19835973 2203013 *regulates* [mucin] production via ERK phosphorylation . Positive_regulation MUC21 SPHK1 19835973 2203077 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Positive_regulation MUC21 TNF 10030839 591793 *stimulates* [mucin] secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro . Positive_regulation MUC21 TNF 10030839 591808 In this study , we investigated potential signaling pathways mediating *induced* [mucin] secretion using guinea pig tracheal epithelial ( GPTE ) cells in air-liquid interface culture . Positive_regulation MUC21 TNF 10030839 591823 Exogenously applied ( human recombinant ) *stimulated* [mucin] secretion in a concentration dependent manner , with maximal effects at 10 to 15 ng/ml ( 286 to 429 U/ml ) . Positive_regulation MUC21 TNF 10030839 591838 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Positive_regulation MUC21 TNF 10030839 591870 Collectively , the results suggest that *stimulates* secretion of [mucin] by GPTE cells via a mechanism ( s ) dependent on PC-PLC and PKC , and involving activation of NOS , generation of NO , production of cGMP , and activation of PKG . Positive_regulation MUC21 TNF 10950784 723461 *Induction* of [mucin] gene expression in middle ear of rats by : potential cause for mucoid otitis media . Positive_regulation MUC21 TNF 11052828 743487 *stimulates* MUC5AC [mucin] secretion in a dose dependent manner , with 20 ng/ml producing maximal stimulation . Positive_regulation MUC21 TNF 11282555 799137 IL-6 and *stimulated* MUC5AC and MUC5B [mucin] secretion in a time dependent manner , both in pre-confluent and post-confluent cells . Positive_regulation MUC21 TNF 12018326 942421 Recent studies demonstrated that , present in human middle ear effusion , *stimulated* mucin production in vitro and up-regulated [mucin] gene expression in vivo . Positive_regulation MUC21 TNF 15696080 1372028 Niflumic acid and MSI-2216 reduce *induced* [mucin] expression in human airway mucosa . Positive_regulation MUC21 TNF 15696080 1372045 Unstimulated and *induced* [mucin] expression could be decreased by NFA and MSI-2216 . Positive_regulation MUC21 TNF 16543607 1582109 We demonstrated that cigarette smoke extract (CSE) synergistically increased gene expression and protein production of MUC5AC [mucin] *induced* by LPS or in human airway epithelial NCI-H292 cells . Positive_regulation MUC21 TNF 19053887 2017603 Both LPS and *increased* MUC5AC [mucin] production in vivo and in vitro , respectively , and fudosteine was found to reduce it by partially interfering with the kinase mediated inflammation pathway that activates the MUC5AC gene . Positive_regulation MUC21 TNF 23463646 2895468 Inhibition of *induced* MUC5AC [mucin] gene expression and production by wogonin through the inactivation of NF-?B signaling in airway epithelial cells . Positive_regulation MUC21 TNF 24348668 2881123 We investigated whether prunetin significantly affects *induced* MUC5AC [mucin] gene expression , production , inhibitory kappa B ( I?B ) degradation and nuclear factor kappa B ( NF-?B ) p65 translocation in human airway epithelial cells . Positive_regulation MUC22 EPHB2 17237423 1690008 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Positive_regulation MUC22 GPR115 15527548 1330215 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC22 GPR132 15527548 1330204 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC22 GPR87 15527548 1330284 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC22 IL1B 12391274 1007523 These results suggest a role for PGE ( 2 ) in *induced* [mucin] synthesis in NCI-H292 cells . Positive_regulation MUC22 IL1B 12391274 1007541 Furthermore , the addition of PGE ( 2 ) to cells overcame the inhibitory effects of both MAPK inhibitors in *induced* [mucin] production . Positive_regulation MUC22 IL1B 12482999 1024559 *induces* MUC2 gene expression and [mucin] secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation MUC22 IL1B 12482999 1024590 In cultured human airway NCI-H292 epithelial cells , the steady state of the mRNA level of MUC2 gene expression and [mucin] secretion *induced* by were determined by reverse transcriptase-polymerase chain reaction ( RT-PCR ) , enzyme immunoassay , and immunoblot analysis . Positive_regulation MUC22 IL1B 12482999 1024605 PD98059 ( MEK/ERK inhibitor ) suppressed *mediated* MUC2 gene expression and [mucin] secretion , while SB203580 ( p38 inhibitor ) did not . Positive_regulation MUC22 IL1B 12482999 1024620 Ro31-8220 ( PKC inhibitor ) inhibited *mediated* MUC2 gene expression and [mucin] secretion . Positive_regulation MUC22 IL1B 12869928 1112246 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Positive_regulation MUC22 IL1B 12869928 1112276 *upregulates* [mucin] secretion from cultured middle ear epithelial cells in a dose- and time dependent manner . Positive_regulation MUC22 IL1B 15266025 1275880 *induced* [mucin] production in human airway epithelium is mediated by cyclooxygenase-2 , prostaglandin E2 receptors , and cyclic AMP-protein kinase A signaling . Positive_regulation MUC22 IL1B 15668323 1382123 increased the thickness of conducting airways , *enhanced* [mucin] production , and caused lymphocytic aggregates in the airways . Positive_regulation MUC22 IL1B 16467705 1523532 Signaling pathways in *mediated* middle ear [mucin] secretion . Positive_regulation MUC22 IL1B 16467705 1523592 *stimulates* [mucin] secretion from middle ear epithelium and its effects can be reversed by IL-1betara . Positive_regulation MUC22 IL1B 20873538 2326427 These results suggest that may *enhance* [mucin] gene expression in cultured human nasal epithelial cells . Positive_regulation MUC22 RARB 10024510 590852 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Positive_regulation MUC22 SPHK1 19835973 2203015 *regulates* [mucin] production via ERK phosphorylation . Positive_regulation MUC22 SPHK1 19835973 2203081 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Positive_regulation MUC22 TNF 10030839 591795 *stimulates* [mucin] secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro . Positive_regulation MUC22 TNF 10030839 591810 In this study , we investigated potential signaling pathways mediating *induced* [mucin] secretion using guinea pig tracheal epithelial ( GPTE ) cells in air-liquid interface culture . Positive_regulation MUC22 TNF 10030839 591825 Exogenously applied ( human recombinant ) *stimulated* [mucin] secretion in a concentration dependent manner , with maximal effects at 10 to 15 ng/ml ( 286 to 429 U/ml ) . Positive_regulation MUC22 TNF 10030839 591840 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Positive_regulation MUC22 TNF 10030839 591872 Collectively , the results suggest that *stimulates* secretion of [mucin] by GPTE cells via a mechanism ( s ) dependent on PC-PLC and PKC , and involving activation of NOS , generation of NO , production of cGMP , and activation of PKG . Positive_regulation MUC22 TNF 10950784 723463 *Induction* of [mucin] gene expression in middle ear of rats by : potential cause for mucoid otitis media . Positive_regulation MUC22 TNF 11052828 743489 *stimulates* MUC5AC [mucin] secretion in a dose dependent manner , with 20 ng/ml producing maximal stimulation . Positive_regulation MUC22 TNF 11282555 799141 IL-6 and *stimulated* MUC5AC and MUC5B [mucin] secretion in a time dependent manner , both in pre-confluent and post-confluent cells . Positive_regulation MUC22 TNF 12018326 942423 Recent studies demonstrated that , present in human middle ear effusion , *stimulated* mucin production in vitro and up-regulated [mucin] gene expression in vivo . Positive_regulation MUC22 TNF 15696080 1372030 Niflumic acid and MSI-2216 reduce *induced* [mucin] expression in human airway mucosa . Positive_regulation MUC22 TNF 15696080 1372047 Unstimulated and *induced* [mucin] expression could be decreased by NFA and MSI-2216 . Positive_regulation MUC22 TNF 16543607 1582113 We demonstrated that cigarette smoke extract (CSE) synergistically increased gene expression and protein production of MUC5AC [mucin] *induced* by LPS or in human airway epithelial NCI-H292 cells . Positive_regulation MUC22 TNF 19053887 2017605 Both LPS and *increased* MUC5AC [mucin] production in vivo and in vitro , respectively , and fudosteine was found to reduce it by partially interfering with the kinase mediated inflammation pathway that activates the MUC5AC gene . Positive_regulation MUC22 TNF 23463646 2895470 Inhibition of *induced* MUC5AC [mucin] gene expression and production by wogonin through the inactivation of NF-?B signaling in airway epithelial cells . Positive_regulation MUC22 TNF 24348668 2881125 We investigated whether prunetin significantly affects *induced* MUC5AC [mucin] gene expression , production , inhibitory kappa B ( I?B ) degradation and nuclear factor kappa B ( NF-?B ) p65 translocation in human airway epithelial cells . Positive_regulation MUC3A MUC16 12740338 1088173 To determine whether increased epithelial cell MUC3 expression in response to Lactobacillus strains *results* in increased extracellular secretion of MUC3 mucins and the importance of epithelial cell adherence in modulation of [MUC3] mucin expression . Positive_regulation MUC4 EPHB2 10980611 731543 *dependent* regulation of sialomucin complex/rat [Muc4] in mammary epithelial cells . Positive_regulation MUC4 EPHB2 17237423 1690018 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Positive_regulation MUC4 FOXA1 17553805 1773808 The human mucin [MUC4] is transcriptionally *regulated* by caudal related homeobox , hepatocyte nuclear factors , , and GATA endodermal transcription factors in epithelial cancer cells . Positive_regulation MUC4 FOXA1 17553805 1773816 Experiments using small interfering RNA , cell co-transfection , and site directed mutagenesis indicated that [MUC4] is *regulated* at the transcriptional level by CDX-1 and -2 , HNF-1 alpha and -1 beta , , HNF-4 alpha and -4 gamma , and GATA-4 , -5 , and -6 factors in a cell-specific manner . Positive_regulation MUC4 GPR115 15527548 1330680 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC4 GPR132 15527548 1330669 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC4 GPR87 15527548 1330749 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC4 IL1B 12391274 1007528 These results suggest a role for PGE ( 2 ) in *induced* [mucin] synthesis in NCI-H292 cells . Positive_regulation MUC4 IL1B 12391274 1007546 Furthermore , the addition of PGE ( 2 ) to cells overcame the inhibitory effects of both MAPK inhibitors in *induced* [mucin] production . Positive_regulation MUC4 IL1B 12482999 1024579 *induces* MUC2 gene expression and [mucin] secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation MUC4 IL1B 12482999 1024595 In cultured human airway NCI-H292 epithelial cells , the steady state of the mRNA level of MUC2 gene expression and [mucin] secretion *induced* by were determined by reverse transcriptase-polymerase chain reaction ( RT-PCR ) , enzyme immunoassay , and immunoblot analysis . Positive_regulation MUC4 IL1B 12482999 1024610 PD98059 ( MEK/ERK inhibitor ) suppressed *mediated* MUC2 gene expression and [mucin] secretion , while SB203580 ( p38 inhibitor ) did not . Positive_regulation MUC4 IL1B 12482999 1024625 Ro31-8220 ( PKC inhibitor ) inhibited *mediated* MUC2 gene expression and [mucin] secretion . Positive_regulation MUC4 IL1B 12869928 1112251 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Positive_regulation MUC4 IL1B 12869928 1112281 *upregulates* [mucin] secretion from cultured middle ear epithelial cells in a dose- and time dependent manner . Positive_regulation MUC4 IL1B 15266025 1275890 *induced* [mucin] production in human airway epithelium is mediated by cyclooxygenase-2 , prostaglandin E2 receptors , and cyclic AMP-protein kinase A signaling . Positive_regulation MUC4 IL1B 15668323 1382128 increased the thickness of conducting airways , *enhanced* [mucin] production , and caused lymphocytic aggregates in the airways . Positive_regulation MUC4 IL1B 16467705 1523537 Signaling pathways in *mediated* middle ear [mucin] secretion . Positive_regulation MUC4 IL1B 16467705 1523597 *stimulates* [mucin] secretion from middle ear epithelium and its effects can be reversed by IL-1betara . Positive_regulation MUC4 IL1B 20062084 2225440 These differences can be attributed to specific cytokines , because TNF-alpha and *induced* MUC2 but no [MUC4] expression in gastric cancer cell lines . Positive_regulation MUC4 IL1B 20566912 2280154 Retinoic acid and *increased* [MUC4] expression at the gene and protein level in HNPE cells , whereas MUC16 expression was not affected . Positive_regulation MUC4 IL1B 20873538 2326432 These results suggest that may *enhance* [mucin] gene expression in cultured human nasal epithelial cells . Positive_regulation MUC4 MMP7 18436821 1900355 and neutrophil elastase *induced* the release of MUC16 but not of MUC1 or [MUC4] . Positive_regulation MUC4 MUC16 20697346 2335438 [MUC4] *induced* epithelial to mesenchymal transition : a novel mechanism for metastasis of human ovarian cancer cells . Positive_regulation MUC4 RARB 10024510 590857 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Positive_regulation MUC4 SPHK1 19835973 2203020 *regulates* [mucin] production via ERK phosphorylation . Positive_regulation MUC4 SPHK1 19835973 2203091 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Positive_regulation MUC4 TNF 10030839 591800 *stimulates* [mucin] secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro . Positive_regulation MUC4 TNF 10030839 591815 In this study , we investigated potential signaling pathways mediating *induced* [mucin] secretion using guinea pig tracheal epithelial ( GPTE ) cells in air-liquid interface culture . Positive_regulation MUC4 TNF 10030839 591830 Exogenously applied ( human recombinant ) *stimulated* [mucin] secretion in a concentration dependent manner , with maximal effects at 10 to 15 ng/ml ( 286 to 429 U/ml ) . Positive_regulation MUC4 TNF 10030839 591845 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Positive_regulation MUC4 TNF 10030839 591877 Collectively , the results suggest that *stimulates* secretion of [mucin] by GPTE cells via a mechanism ( s ) dependent on PC-PLC and PKC , and involving activation of NOS , generation of NO , production of cGMP , and activation of PKG . Positive_regulation MUC4 TNF 10950784 723468 *Induction* of [mucin] gene expression in middle ear of rats by : potential cause for mucoid otitis media . Positive_regulation MUC4 TNF 11052828 743494 *stimulates* MUC5AC [mucin] secretion in a dose dependent manner , with 20 ng/ml producing maximal stimulation . Positive_regulation MUC4 TNF 11282555 799151 IL-6 and *stimulated* MUC5AC and MUC5B [mucin] secretion in a time dependent manner , both in pre-confluent and post-confluent cells . Positive_regulation MUC4 TNF 12018326 942428 Recent studies demonstrated that , present in human middle ear effusion , *stimulated* mucin production in vitro and up-regulated [mucin] gene expression in vivo . Positive_regulation MUC4 TNF 15696080 1372035 Niflumic acid and MSI-2216 reduce *induced* [mucin] expression in human airway mucosa . Positive_regulation MUC4 TNF 15696080 1372052 Unstimulated and *induced* [mucin] expression could be decreased by NFA and MSI-2216 . Positive_regulation MUC4 TNF 16543607 1582123 We demonstrated that cigarette smoke extract (CSE) synergistically increased gene expression and protein production of MUC5AC [mucin] *induced* by LPS or in human airway epithelial NCI-H292 cells . Positive_regulation MUC4 TNF 18436821 1900343 *induced* the release of MUC1 , [MUC4] , and MUC16 from the HCLE surface . Positive_regulation MUC4 TNF 19053887 2017610 Both LPS and *increased* MUC5AC [mucin] production in vivo and in vitro , respectively , and fudosteine was found to reduce it by partially interfering with the kinase mediated inflammation pathway that activates the MUC5AC gene . Positive_regulation MUC4 TNF 20062084 2225439 These differences can be attributed to specific cytokines , because and IL-1beta *induced* MUC2 but no [MUC4] expression in gastric cancer cell lines . Positive_regulation MUC4 TNF 23463646 2895475 Inhibition of *induced* MUC5AC [mucin] gene expression and production by wogonin through the inactivation of NF-?B signaling in airway epithelial cells . Positive_regulation MUC4 TNF 24348668 2881130 We investigated whether prunetin significantly affects *induced* MUC5AC [mucin] gene expression , production , inhibitory kappa B ( I?B ) degradation and nuclear factor kappa B ( NF-?B ) p65 translocation in human airway epithelial cells . Positive_regulation MUC5AC CHI3L1 23994362 2856080 The chitinase-like protein *increases* [mucin5AC] production in human bronchial epithelial cells . Positive_regulation MUC5AC CHI3L1 23994362 2856082 Taken together , these results imply that can *stimulate* excessive [MUC5AC] production through PAR2- and FAK mediated mechanisms . Positive_regulation MUC5AC EPHB2 15985706 1429023 The [gastric mucin] secretory responses to isoproterenol , furthermore , were *inhibited* by PP2 , a selective inhibitor of tyrosine kinase Src responsible for ligand independent EGFR autophosphorylation , but not by inhibitor , PD98059 . Positive_regulation MUC5AC EPHB2 17237423 1690020 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of [MUC5AC] mucin transcription by Streptococcus pneumoniae . Positive_regulation MUC5AC EPHB2 17555715 1753093 Moreover , activation of both p38 and is *required* for synergistic induction of [MUC5AC] by NTHi and EGF . Positive_regulation MUC5AC EPHB2 22260247 2544947 Inhibitors of and JNK , but not p38 , dose-dependently *inhibited* the induction of [MUC5AC] by live L. pneumophila . Positive_regulation MUC5AC EPHB2 22441738 2658252 Moreover , the 12R-LOX product 12 ( R ) -hydroxyeicosatetraenoic acid , *induces* [MUC5AC] expression , activation and Sp1 translocation . Positive_regulation MUC5AC EPHB2 22610099 2619884 We also found that MAPK phosphatase-1 (MKP-1) negatively regulates S. pneumoniae induced *dependent* [MUC5AC] up-regulation . Positive_regulation MUC5AC EPHB2 22610099 2619894 Collectively , these data demonstrate that PDE4B mediates *dependent* up-regulation of mucin [MUC5AC] by S. pneumoniae by inhibiting cAMP-PKA dependent MKP-1 pathway . Positive_regulation MUC5AC GPR115 15985706 1428688 [Gastric mucin] secretion in *response* to beta-adrenergic activation is mediated by SRC kinase dependent epidermal growth factor receptor transactivation . Positive_regulation MUC5AC GPR132 15985706 1428677 [Gastric mucin] secretion in *response* to beta-adrenergic activation is mediated by SRC kinase dependent epidermal growth factor receptor transactivation . Positive_regulation MUC5AC GPR87 15985706 1428758 [Gastric mucin] secretion in *response* to beta-adrenergic activation is mediated by SRC kinase dependent epidermal growth factor receptor transactivation . Positive_regulation MUC5AC IL1B 12391274 1007516 *induces* MUC2 and [MUC5AC] synthesis through cyclooxygenase-2 in NCI-H292 cells . Positive_regulation MUC5AC IL1B 12391274 1007533 Cells activated by IL-1beta showed increased extracellular signal regulated kinase ( ERK ) 1/2 and p38 phosphorylation , and *induced* MUC2 and [MUC5AC] production was blocked by the ERK pathway inhibitor PD98059 or the p38 inhibitor SB203580 . Positive_regulation MUC5AC IL1B 12690113 1099951 and tumor necrosis factor-alpha *induce* [MUC5AC] overexpression through a mechanism involving ERK/p38 mitogen activated protein kinases-MSK1-CREB activation in human airway epithelial cells . Positive_regulation MUC5AC IL1B 15266025 1275898 The goal of the present study was to elucidate the signaling pathways involved in *induced* [MUC5AC] production . Positive_regulation MUC5AC IL1B 15266025 1275900 We found that IL-1beta increased cyclooxygenase-2 (COX-2) mRNA expression and prostaglandin ( PG ) E ( 2 ) production and that the COX-2 inhibitor celecoxib suppressed *induced* [MUC5AC] production . Positive_regulation MUC5AC IL1B 15266025 1275998 We conclude that the *induction* of [MUC5AC] by , TNF-alpha , PAF , and LPS involves COX-2- generated PGE ( 2 ) , activation of EP2 and/or EP4 receptor ( s ) , and cAMP-PKA mediated signaling . Positive_regulation MUC5AC IL1B 18155512 1931757 Epigallocatechin-3-gallate inhibits *induced* [MUC5AC] gene expression and MUC5AC secretion in normal human nasal epithelial cells . Positive_regulation MUC5AC IL1B 18155512 1931758 It has been reported that the proinflammatory cytokine interleukin-1beta (IL-1beta) induces mucus hypersecretion in normal human nasal epithelial ( NHNE ) cells and that the MAP kinase pathway may be an important signal pathway in *induced* [MUC5AC] gene expression . Positive_regulation MUC5AC IL1B 18155512 1931759 In this study , we examined the effect of ( - ) -epigallocatechin-3-gallate ( EGCG ) , a green tea polyphenol , on *induced* [MUC5AC] gene expression and secretion in NHNE cells . Positive_regulation MUC5AC IL1B 18155512 1931760 *increased* [MUC5AC] gene expression and MUC5AC secretion . Positive_regulation MUC5AC IL1B 18155512 1931761 EGCG markedly suppressed *induced* [MUC5AC] gene expression and MUC5AC secretion via suppression of the phosphorylation of ERK MAP kinase , MSK1 , and transcription factor , cAMP response element binding protein . Positive_regulation MUC5AC IL1B 19367675 2167939 Kaempferol and quercetin , essential ingredients in Ginkgo biloba extract , inhibit *induced* [MUC5AC] gene expression in human airway epithelial cells . Positive_regulation MUC5AC IL1B 19367675 2167940 According to our previous study , Ginkgo biloba extract ( GBE ) suppresses *induced* [MUC5AC] gene expression in NCI-H292 cells via the ERK and p38 MAPK pathways . Positive_regulation MUC5AC IL1B 19367675 2167941 This study sought to identify which ingredients of GBE suppress *induced* [MUC5AC] gene expression in NCI-H292 cells and to examine which MAPKs are related to MUC5AC gene suppression for each ingredient . Positive_regulation MUC5AC IL1B 19671252 2119465 [ 6 ] -Gingerol suppresses *induced* [MUC5AC] gene expression in human airway epithelial cells . Positive_regulation MUC5AC IL1B 19671252 2119466 The present study investigated whether [ 6 ] -gingerol suppresses *induced* [MUC5AC] gene expression in human airway epithelial cells and , if so , examined whether the suppression of MUC5AC gene expression is mediated via the mitogen activated protein kinase (MAPK) signal transduction pathway . Positive_regulation MUC5AC MAP2K6 24556756 2919264 Either EGF neutralizing antibody or specific inhibitor ( PD-98059 ) could *attenuate* the over synthesis of [MUC5AC] induced by exogenous SN , indicating an endogenous EGF dependent mechanism in MUC5AC over synthesis induced by SN . Positive_regulation MUC5AC MUC16 18166592 1855610 As excess expression can contribute to the exacerbation of asthma , the present authors hypothesised that Mycoplasma pneumoniae significantly *induces* [MUC5AC] ( the major airway mucin ) expression in airway epithelial cells isolated directly from asthmatic subjects . Positive_regulation MUC5AC MUC16 19956440 2172583 Ras-Raf1-ERK1/2 dependent AP-1 activation positively regulates [MUC5AC] *induction* by S. pneumoniae , whereas MEKK3-JNK1/2 dependent AP-1 activation negatively regulates it . Positive_regulation MUC5AC MUC16 19956440 2172677 Therefore , our data unveiled a novel signaling mechanism underlying the tight regulation of [MUC5AC] *induction* by S. pneumoniae and may lead to the development of new therapeutic strategy for reducing mucus overproduction in both OM and COPD . Positive_regulation MUC5AC MUC16 21146382 2437450 Glycyrrhizin and carbenoxolone were found to *inhibit* the production of [MUC5AC] mucin protein induced by EGF or PMA , and both compounds also inhibited the expression of MUC5AC gene induced by EGF or PMA . Positive_regulation MUC5AC MUC16 21442679 2421972 Oleanolic acid and ursolic acid were found to *inhibit* the production of [MUC5AC] mucin protein induced by EGF and PMA , and both compounds also inhibited the expression of MUC5AC gene induced by EGF and PMA . Positive_regulation MUC5AC SPHK1 19835973 2203143 These results suggest that is *involved* in [MUC5AC] production induced by IL-13 upstream of ERK1/2 phosphorylation , and independent of STAT6 phosphorylation . Positive_regulation MUC5AC TNF 10077640 595364 EGF-R ligands increased the expression of [MUC5AC] at both gene and protein levels , and this effect was *potentiated* by . Positive_regulation MUC5AC TNF 11052828 743495 *stimulates* [MUC5AC] mucin secretion in a dose dependent manner , with 20 ng/ml producing maximal stimulation . Positive_regulation MUC5AC TNF 11282555 799153 IL-6 and *stimulated* [MUC5AC] and MUC5B mucin secretion in a time dependent manner , both in pre-confluent and post-confluent cells . Positive_regulation MUC5AC TNF 12690113 1099950 Interleukin-1 beta and *induce* [MUC5AC] overexpression through a mechanism involving ERK/p38 mitogen activated protein kinases-MSK1-CREB activation in human airway epithelial cells . Positive_regulation MUC5AC TNF 12690113 1099954 However , the mechanisms by which the interleukin (IL)-1beta and *induce* [MUC5AC] gene expression in normal nasal epithelial cells , and the signal molecules involved , especially in the downstream signaling of mitogen activated protein ( MAP ) kinases , remain unclear . Positive_regulation MUC5AC TNF 12690113 1099956 Here we show that pharmacologic or genetic inhibition of either ERK or p38 MAP kinase pathway abolished IL-1beta- and *induced* [MUC5AC] gene expression in normal human nasal epithelial cells . Positive_regulation MUC5AC TNF 12690113 1099958 Taken together , these studies give additional insights into the molecular mechanism of IL-1beta- and *induced* [MUC5AC] gene expression and enhance our understanding on mucin hypersecretion during inflammation . Positive_regulation MUC5AC TNF 15266025 1275956 We also observed that , platelet activating factor (PAF) , and lipopolysaccharide (LPS) *induced* COX-2 and increased [MUC5AC] production that was blocked by celecoxib , suggesting a common signaling pathway of inflammatory mediator induced MUC5AC production in NHTBE cells . Positive_regulation MUC5AC TNF 15513533 1328321 Extracellular signal regulated kinase is involved in *induced* [MUC5AC] gene expression in cultured human nasal polyp epithelial cells . Positive_regulation MUC5AC TNF 15513533 1328322 We then examined whether *induces* [MUC5AC] gene expression and whether extracellular signal regulated kinase ( ERK ) plays a role in TNF-alpha induced MUC5AC gene expression in cultured human nasal polyp epithelial cells . Positive_regulation MUC5AC TNF 15513533 1328325 *induced* [MUC5AC] gene expression , and ERK activation was found to be essential for TNF-alpha induced MUC5AC gene expression in cultured human nasal polyp epithelial cells . Positive_regulation MUC5AC TNF 15513533 1328327 *induces* [MUC5AC] gene expression via ERK in cultured human nasal polyp epithelial cells . Positive_regulation MUC5AC TNF 15696080 1372040 significantly *increased* [MUC5AC] and hCLCA1 mRNA as well as mucus and hCLCA1 protein expression in the mucosal explant tissue ( P < .05 ) . Positive_regulation MUC5AC TNF 15864435 1401349 *induced* expression of hST3GalIV , FUT3 , C2/4GnT and [MUC5AC] mRNAs in NCI-H292 cells . Positive_regulation MUC5AC TNF 19053887 2017611 Both LPS and *increased* [MUC5AC] mucin production in vivo and in vitro , respectively , and fudosteine was found to reduce it by partially interfering with the kinase mediated inflammation pathway that activates the MUC5AC gene . Positive_regulation MUC5AC TNF 19852193 2155684 *induced* [MUC-5AC] expression in human airway culture significantly decreased with pretreatment of a NF-kappaB inhibitor . Positive_regulation MUC5AC TNF 20513186 2270733 Data suggested that a nuclear factor KB-based transcriptional mechanism is involved in *induction* of [MUC5AC] expression by . Positive_regulation MUC5AC TNF 20639461 2418983 Because MUC5AC expression is known to be up-regulated by TNF-a via NF-?B activation , we evaluated the inhibitory effect of a-MSH on [MUC5AC] gene expression *induced* by in normal human nasal epithelial ( NHNE ) cells . Positive_regulation MUC5AC TNF 20639461 2418995 Real-time quantitative PCR data showed that a-MSH inhibited *induced* expression of [MUC5AC] , and this effect of a-MSH was neutralized by knockdown of MC-1R using MC-1R shRNA lentivirus . Positive_regulation MUC5AC TNF 21418911 2405597 [ Regulation of sphingosine kinase 1 in the *induced* expression of [MUC5AC] in airway epithelial cells ] . Positive_regulation MUC5AC TNF 22391959 2600436 In contrast , and interleukin-1ß at levels equivalent to supernatant from LPS treated MDM *increased* [MUC5AC] . Positive_regulation MUC5AC TNF 23463646 2895476 Inhibition of *induced* [MUC5AC] mucin gene expression and production by wogonin through the inactivation of NF-?B signaling in airway epithelial cells . Positive_regulation MUC5AC TNF 23463646 2895480 We found that incubation of NCI-H292 cells with wogonin significantly inhibited mucin production and down-regulated [MUC5AC] gene expression *induced* by in a dose dependent fashion . Positive_regulation MUC5AC TNF 24348668 2881131 We investigated whether prunetin significantly affects *induced* [MUC5AC] mucin gene expression , production , inhibitory kappa B ( I?B ) degradation and nuclear factor kappa B ( NF-?B ) p65 translocation in human airway epithelial cells . Positive_regulation MUC5AC TNF 24348668 2881136 We found that incubation of NCI-H292 cells with prunetin significantly inhibited mucin production and down-regulated the [MUC5AC] gene expression *induced* by . Positive_regulation MUC5B IL1B 20873538 2326420 *increased* [MUC2/MUC5B] mRNA levels in human nasal epithelial cells . Positive_regulation MUC6 EPHB2 17237423 1690022 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Positive_regulation MUC6 GPR115 15527548 1330773 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC6 GPR132 15527548 1330762 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC6 GPR87 15527548 1330842 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC6 IL1B 12391274 1007529 These results suggest a role for PGE ( 2 ) in *induced* [mucin] synthesis in NCI-H292 cells . Positive_regulation MUC6 IL1B 12391274 1007547 Furthermore , the addition of PGE ( 2 ) to cells overcame the inhibitory effects of both MAPK inhibitors in *induced* [mucin] production . Positive_regulation MUC6 IL1B 12482999 1024580 *induces* MUC2 gene expression and [mucin] secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation MUC6 IL1B 12482999 1024596 In cultured human airway NCI-H292 epithelial cells , the steady state of the mRNA level of MUC2 gene expression and [mucin] secretion *induced* by were determined by reverse transcriptase-polymerase chain reaction ( RT-PCR ) , enzyme immunoassay , and immunoblot analysis . Positive_regulation MUC6 IL1B 12482999 1024611 PD98059 ( MEK/ERK inhibitor ) suppressed *mediated* MUC2 gene expression and [mucin] secretion , while SB203580 ( p38 inhibitor ) did not . Positive_regulation MUC6 IL1B 12482999 1024626 Ro31-8220 ( PKC inhibitor ) inhibited *mediated* MUC2 gene expression and [mucin] secretion . Positive_regulation MUC6 IL1B 12869928 1112252 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Positive_regulation MUC6 IL1B 12869928 1112282 *upregulates* [mucin] secretion from cultured middle ear epithelial cells in a dose- and time dependent manner . Positive_regulation MUC6 IL1B 15266025 1275892 *induced* [mucin] production in human airway epithelium is mediated by cyclooxygenase-2 , prostaglandin E2 receptors , and cyclic AMP-protein kinase A signaling . Positive_regulation MUC6 IL1B 15668323 1382129 increased the thickness of conducting airways , *enhanced* [mucin] production , and caused lymphocytic aggregates in the airways . Positive_regulation MUC6 IL1B 16467705 1523538 Signaling pathways in *mediated* middle ear [mucin] secretion . Positive_regulation MUC6 IL1B 16467705 1523598 *stimulates* [mucin] secretion from middle ear epithelium and its effects can be reversed by IL-1betara . Positive_regulation MUC6 IL1B 20873538 2326433 These results suggest that may *enhance* [mucin] gene expression in cultured human nasal epithelial cells . Positive_regulation MUC6 RARB 10024510 590858 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Positive_regulation MUC6 SPHK1 19835973 2203021 *regulates* [mucin] production via ERK phosphorylation . Positive_regulation MUC6 SPHK1 19835973 2203093 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Positive_regulation MUC6 TNF 10030839 591801 *stimulates* [mucin] secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro . Positive_regulation MUC6 TNF 10030839 591816 In this study , we investigated potential signaling pathways mediating *induced* [mucin] secretion using guinea pig tracheal epithelial ( GPTE ) cells in air-liquid interface culture . Positive_regulation MUC6 TNF 10030839 591831 Exogenously applied ( human recombinant ) *stimulated* [mucin] secretion in a concentration dependent manner , with maximal effects at 10 to 15 ng/ml ( 286 to 429 U/ml ) . Positive_regulation MUC6 TNF 10030839 591846 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Positive_regulation MUC6 TNF 10030839 591878 Collectively , the results suggest that *stimulates* secretion of [mucin] by GPTE cells via a mechanism ( s ) dependent on PC-PLC and PKC , and involving activation of NOS , generation of NO , production of cGMP , and activation of PKG . Positive_regulation MUC6 TNF 10950784 723469 *Induction* of [mucin] gene expression in middle ear of rats by : potential cause for mucoid otitis media . Positive_regulation MUC6 TNF 11052828 743496 *stimulates* MUC5AC [mucin] secretion in a dose dependent manner , with 20 ng/ml producing maximal stimulation . Positive_regulation MUC6 TNF 11282555 799155 IL-6 and *stimulated* MUC5AC and MUC5B [mucin] secretion in a time dependent manner , both in pre-confluent and post-confluent cells . Positive_regulation MUC6 TNF 12018326 942429 Recent studies demonstrated that , present in human middle ear effusion , *stimulated* [mucin] production in vitro and up-regulated mucin gene expression in vivo . Positive_regulation MUC6 TNF 15696080 1372036 Niflumic acid and MSI-2216 reduce *induced* [mucin] expression in human airway mucosa . Positive_regulation MUC6 TNF 15696080 1372053 Unstimulated and *induced* [mucin] expression could be decreased by NFA and MSI-2216 . Positive_regulation MUC6 TNF 16543607 1582125 We demonstrated that cigarette smoke extract (CSE) synergistically increased gene expression and protein production of MUC5AC [mucin] *induced* by LPS or in human airway epithelial NCI-H292 cells . Positive_regulation MUC6 TNF 19053887 2017612 Both LPS and *increased* MUC5AC [mucin] production in vivo and in vitro , respectively , and fudosteine was found to reduce it by partially interfering with the kinase mediated inflammation pathway that activates the MUC5AC gene . Positive_regulation MUC6 TNF 23463646 2895477 Inhibition of *induced* MUC5AC [mucin] gene expression and production by wogonin through the inactivation of NF-?B signaling in airway epithelial cells . Positive_regulation MUC6 TNF 24348668 2881132 We investigated whether prunetin significantly affects *induced* MUC5AC [mucin] gene expression , production , inhibitory kappa B ( I?B ) degradation and nuclear factor kappa B ( NF-?B ) p65 translocation in human airway epithelial cells . Positive_regulation MUC7 EPHB2 17237423 1690024 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Positive_regulation MUC7 GPR115 15527548 1330866 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC7 GPR132 15527548 1330855 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC7 GPR87 15527548 1330935 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC7 IL1B 12391274 1007530 These results suggest a role for PGE ( 2 ) in *induced* [mucin] synthesis in NCI-H292 cells . Positive_regulation MUC7 IL1B 12391274 1007548 Furthermore , the addition of PGE ( 2 ) to cells overcame the inhibitory effects of both MAPK inhibitors in *induced* [mucin] production . Positive_regulation MUC7 IL1B 12482999 1024581 *induces* MUC2 gene expression and [mucin] secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation MUC7 IL1B 12482999 1024597 In cultured human airway NCI-H292 epithelial cells , the steady state of the mRNA level of MUC2 gene expression and [mucin] secretion *induced* by were determined by reverse transcriptase-polymerase chain reaction ( RT-PCR ) , enzyme immunoassay , and immunoblot analysis . Positive_regulation MUC7 IL1B 12482999 1024612 PD98059 ( MEK/ERK inhibitor ) suppressed *mediated* MUC2 gene expression and [mucin] secretion , while SB203580 ( p38 inhibitor ) did not . Positive_regulation MUC7 IL1B 12482999 1024627 Ro31-8220 ( PKC inhibitor ) inhibited *mediated* MUC2 gene expression and [mucin] secretion . Positive_regulation MUC7 IL1B 12869928 1112253 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Positive_regulation MUC7 IL1B 12869928 1112283 *upregulates* [mucin] secretion from cultured middle ear epithelial cells in a dose- and time dependent manner . Positive_regulation MUC7 IL1B 15266025 1275894 *induced* [mucin] production in human airway epithelium is mediated by cyclooxygenase-2 , prostaglandin E2 receptors , and cyclic AMP-protein kinase A signaling . Positive_regulation MUC7 IL1B 15668323 1382130 increased the thickness of conducting airways , *enhanced* [mucin] production , and caused lymphocytic aggregates in the airways . Positive_regulation MUC7 IL1B 16467705 1523539 Signaling pathways in *mediated* middle ear [mucin] secretion . Positive_regulation MUC7 IL1B 16467705 1523599 *stimulates* [mucin] secretion from middle ear epithelium and its effects can be reversed by IL-1betara . Positive_regulation MUC7 IL1B 20873538 2326434 These results suggest that may *enhance* [mucin] gene expression in cultured human nasal epithelial cells . Positive_regulation MUC7 RARB 10024510 590859 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Positive_regulation MUC7 SPHK1 19835973 2203022 *regulates* [mucin] production via ERK phosphorylation . Positive_regulation MUC7 SPHK1 19835973 2203095 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Positive_regulation MUC7 TNF 10030839 591802 *stimulates* [mucin] secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro . Positive_regulation MUC7 TNF 10030839 591817 In this study , we investigated potential signaling pathways mediating *induced* [mucin] secretion using guinea pig tracheal epithelial ( GPTE ) cells in air-liquid interface culture . Positive_regulation MUC7 TNF 10030839 591832 Exogenously applied ( human recombinant ) *stimulated* [mucin] secretion in a concentration dependent manner , with maximal effects at 10 to 15 ng/ml ( 286 to 429 U/ml ) . Positive_regulation MUC7 TNF 10030839 591847 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Positive_regulation MUC7 TNF 10030839 591879 Collectively , the results suggest that *stimulates* secretion of [mucin] by GPTE cells via a mechanism ( s ) dependent on PC-PLC and PKC , and involving activation of NOS , generation of NO , production of cGMP , and activation of PKG . Positive_regulation MUC7 TNF 10950784 723470 *Induction* of [mucin] gene expression in middle ear of rats by : potential cause for mucoid otitis media . Positive_regulation MUC7 TNF 11052828 743497 *stimulates* MUC5AC [mucin] secretion in a dose dependent manner , with 20 ng/ml producing maximal stimulation . Positive_regulation MUC7 TNF 11282555 799157 IL-6 and *stimulated* MUC5AC and MUC5B [mucin] secretion in a time dependent manner , both in pre-confluent and post-confluent cells . Positive_regulation MUC7 TNF 12018326 942430 Recent studies demonstrated that , present in human middle ear effusion , *stimulated* mucin production in vitro and up-regulated [mucin] gene expression in vivo . Positive_regulation MUC7 TNF 15696080 1372037 Niflumic acid and MSI-2216 reduce *induced* [mucin] expression in human airway mucosa . Positive_regulation MUC7 TNF 15696080 1372054 Unstimulated and *induced* [mucin] expression could be decreased by NFA and MSI-2216 . Positive_regulation MUC7 TNF 16543607 1582127 We demonstrated that cigarette smoke extract (CSE) synergistically increased gene expression and protein production of MUC5AC [mucin] *induced* by LPS or in human airway epithelial NCI-H292 cells . Positive_regulation MUC7 TNF 16778149 1631588 AP1 elements played an essential role in the constitutive expression , while the NF-kappaB element was crucially important in the response to TNF-alpha stimulation , demonstrating that *activates* [MUC7] transcription via NF-kappaB signaling pathway . Positive_regulation MUC7 TNF 19053887 2017613 Both LPS and *increased* MUC5AC [mucin] production in vivo and in vitro , respectively , and fudosteine was found to reduce it by partially interfering with the kinase mediated inflammation pathway that activates the MUC5AC gene . Positive_regulation MUC7 TNF 23463646 2895478 Inhibition of *induced* MUC5AC [mucin] gene expression and production by wogonin through the inactivation of NF-?B signaling in airway epithelial cells . Positive_regulation MUC7 TNF 24348668 2881133 We investigated whether prunetin significantly affects *induced* MUC5AC [mucin] gene expression , production , inhibitory kappa B ( I?B ) degradation and nuclear factor kappa B ( NF-?B ) p65 translocation in human airway epithelial cells . Positive_regulation MUC8 EPHB2 17237423 1690026 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Positive_regulation MUC8 GPR115 15527548 1330959 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC8 GPR132 15527548 1330948 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC8 GPR87 15527548 1331028 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Positive_regulation MUC8 IL1B 12391274 1007531 These results suggest a role for PGE ( 2 ) in *induced* [mucin] synthesis in NCI-H292 cells . Positive_regulation MUC8 IL1B 12391274 1007549 Furthermore , the addition of PGE ( 2 ) to cells overcame the inhibitory effects of both MAPK inhibitors in *induced* [mucin] production . Positive_regulation MUC8 IL1B 12482999 1024582 *induces* MUC2 gene expression and [mucin] secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells . Positive_regulation MUC8 IL1B 12482999 1024598 In cultured human airway NCI-H292 epithelial cells , the steady state of the mRNA level of MUC2 gene expression and [mucin] secretion *induced* by were determined by reverse transcriptase-polymerase chain reaction ( RT-PCR ) , enzyme immunoassay , and immunoblot analysis . Positive_regulation MUC8 IL1B 12482999 1024613 PD98059 ( MEK/ERK inhibitor ) suppressed *mediated* MUC2 gene expression and [mucin] secretion , while SB203580 ( p38 inhibitor ) did not . Positive_regulation MUC8 IL1B 12482999 1024628 Ro31-8220 ( PKC inhibitor ) inhibited *mediated* MUC2 gene expression and [mucin] secretion . Positive_regulation MUC8 IL1B 12842905 1134816 *Induction* of [MUC8] gene expression by is mediated by a sequential ERK MAPK/RSK1/CREB cascade pathway in human airway epithelial cells . Positive_regulation MUC8 IL1B 12842905 1134844 We found that pharmacologic and genetic inhibition of ERK MAPK pathway abolished *induced* [MUC8] gene expression in normal human nasal epithelial cells . Positive_regulation MUC8 IL1B 12842905 1134845 Moreover , the overexpression of wide-type or of the dominant negative mutant of p90 ribosomal S6 protein kinase 1 (RSK1) enhanced or suppressed , respectively , *induced* [MUC8] gene expression . Positive_regulation MUC8 IL1B 12869928 1112254 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Positive_regulation MUC8 IL1B 12869928 1112284 *upregulates* [mucin] secretion from cultured middle ear epithelial cells in a dose- and time dependent manner . Positive_regulation MUC8 IL1B 15266025 1275896 *induced* [mucin] production in human airway epithelium is mediated by cyclooxygenase-2 , prostaglandin E2 receptors , and cyclic AMP-protein kinase A signaling . Positive_regulation MUC8 IL1B 15668323 1382131 increased the thickness of conducting airways , *enhanced* [mucin] production , and caused lymphocytic aggregates in the airways . Positive_regulation MUC8 IL1B 16467705 1523540 Signaling pathways in *mediated* middle ear [mucin] secretion . Positive_regulation MUC8 IL1B 16467705 1523600 *stimulates* [mucin] secretion from middle ear epithelium and its effects can be reversed by IL-1betara . Positive_regulation MUC8 IL1B 18952062 1989262 Interaction of SOCS3 with NonO attenuates *dependent* [MUC8] gene expression . Positive_regulation MUC8 IL1B 18952062 1989264 The intracellular negatively regulatory mechanism which affects *induced* [MUC8] gene expression remains unclear . Positive_regulation MUC8 IL1B 18952062 1989266 We found that SOCS3 overexpression suppressed IL-1beta induced MUC8 gene expression in NCI-H292 cells , whereas silencing of SOCS3 restored *induced* [MUC8] gene expression . Positive_regulation MUC8 IL1B 20873538 2326435 These results suggest that may *enhance* [mucin] gene expression in cultured human nasal epithelial cells . Positive_regulation MUC8 RARB 10024510 590860 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Positive_regulation MUC8 SPHK1 19835973 2203023 *regulates* [mucin] production via ERK phosphorylation . Positive_regulation MUC8 SPHK1 19835973 2203097 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Positive_regulation MUC8 TNF 10030839 591803 *stimulates* [mucin] secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro . Positive_regulation MUC8 TNF 10030839 591818 In this study , we investigated potential signaling pathways mediating *induced* [mucin] secretion using guinea pig tracheal epithelial ( GPTE ) cells in air-liquid interface culture . Positive_regulation MUC8 TNF 10030839 591833 Exogenously applied ( human recombinant ) *stimulated* [mucin] secretion in a concentration dependent manner , with maximal effects at 10 to 15 ng/ml ( 286 to 429 U/ml ) . Positive_regulation MUC8 TNF 10030839 591848 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Positive_regulation MUC8 TNF 10030839 591880 Collectively , the results suggest that *stimulates* secretion of [mucin] by GPTE cells via a mechanism ( s ) dependent on PC-PLC and PKC , and involving activation of NOS , generation of NO , production of cGMP , and activation of PKG . Positive_regulation MUC8 TNF 10950784 723471 *Induction* of [mucin] gene expression in middle ear of rats by : potential cause for mucoid otitis media . Positive_regulation MUC8 TNF 11052828 743498 *stimulates* MUC5AC [mucin] secretion in a dose dependent manner , with 20 ng/ml producing maximal stimulation . Positive_regulation MUC8 TNF 11282555 799159 IL-6 and *stimulated* MUC5AC and MUC5B [mucin] secretion in a time dependent manner , both in pre-confluent and post-confluent cells . Positive_regulation MUC8 TNF 12018326 942431 Recent studies demonstrated that , present in human middle ear effusion , *stimulated* [mucin] production in vitro and up-regulated mucin gene expression in vivo . Positive_regulation MUC8 TNF 15696080 1372038 Niflumic acid and MSI-2216 reduce *induced* [mucin] expression in human airway mucosa . Positive_regulation MUC8 TNF 15696080 1372055 Unstimulated and *induced* [mucin] expression could be decreased by NFA and MSI-2216 . Positive_regulation MUC8 TNF 16543607 1582129 We demonstrated that cigarette smoke extract (CSE) synergistically increased gene expression and protein production of MUC5AC [mucin] *induced* by LPS or in human airway epithelial NCI-H292 cells . Positive_regulation MUC8 TNF 19053887 2017614 Both LPS and *increased* MUC5AC [mucin] production in vivo and in vitro , respectively , and fudosteine was found to reduce it by partially interfering with the kinase mediated inflammation pathway that activates the MUC5AC gene . Positive_regulation MUC8 TNF 23463646 2895479 Inhibition of *induced* MUC5AC [mucin] gene expression and production by wogonin through the inactivation of NF-?B signaling in airway epithelial cells . Positive_regulation MUC8 TNF 24348668 2881134 We investigated whether prunetin significantly affects *induced* MUC5AC [mucin] gene expression , production , inhibitory kappa B ( I?B ) degradation and nuclear factor kappa B ( NF-?B ) p65 translocation in human airway epithelial cells . Positive_regulation MVD CLDN10 21647678 2451084 [MVD] in HCC *increased* with enhanced expression ( P < 0.01 ) . Positive_regulation MVD MMP7 12903787 1119078 Mean [MVD] was *dependent* on expression in gastric cancer ( P < 0.05 ) . Positive_regulation MX2 ABCB1 10070877 594293 Both IDA and [MX2] *induced* expression within 4 h. 5-FU up-regulated MDR1 expression only when drug exposure was prolonged to 24 h. Based on MRK 16 binding , flow cytometric analysis of P-glycoprotein (Pgp) expression paralleled the increase in MDR1 mRNA levels . Positive_regulation MX2 CCL5 21130742 2372807 Cxcl10 , Mx1 , Ifi44 , Ifi203 , Iigp2 and Rtp4 were dominantly regulated by IPS-1 , by TLR3 , and Rsad2 , [Mx2] and Cmpk2 were *regulated* by TLR3 and IPS-1 . Positive_regulation MX2 EIF4E 21349821 2443431 Of these 514 genes , [MX2] , BST2 , RSAD2 , ISG15 , OAS1 , USP18 , IFI44 , ISG20 , SAMD9 , , and IFIT2 *increased* to the greatest extent in pregnant endometria ( > 8-fold log2 fold change increase ) . Positive_regulation MX2 IFIT2 21349821 2443432 Of these 514 genes , [MX2] , BST2 , RSAD2 , ISG15 , OAS1 , USP18 , IFI44 , ISG20 , SAMD9 , EIF4E , and *increased* to the greatest extent in pregnant endometria ( > 8-fold log2 fold change increase ) . Positive_regulation MX2 MAVS 21130742 2372809 Cxcl10 , Mx1 , Ifi44 , Ifi203 , Iigp2 and Rtp4 were dominantly regulated by IPS-1 , Ccl5 by TLR3 , and Rsad2 , [Mx2] and Cmpk2 were *regulated* by TLR3 and . Positive_regulation MX2 OAS1 19577285 2117541 Furthermore , deficient S100A11 gene expression significantly impaired IL-29 ( IFN-lambda1 ) responsiveness ( <2' 5'-oligoadenylate synthetase> and [Myxovirus [influenza virus] resistance] *induction* ) and its anti-VV effects in keratinocytes . Positive_regulation MX2 OAS2 19577285 2117542 Furthermore , deficient S100A11 gene expression significantly impaired IL-29 ( IFN-lambda1 ) responsiveness ( <2' 5'-oligoadenylate synthetase> and [Myxovirus [influenza virus] resistance] *induction* ) and its anti-VV effects in keratinocytes . Positive_regulation MX2 OAS3 19577285 2117543 Furthermore , deficient S100A11 gene expression significantly impaired IL-29 ( IFN-lambda1 ) responsiveness ( <2' 5'-oligoadenylate synthetase> and [Myxovirus [influenza virus] resistance] *induction* ) and its anti-VV effects in keratinocytes . Positive_regulation MX2 SAMD9 21349821 2443430 Of these 514 genes , [MX2] , BST2 , RSAD2 , ISG15 , OAS1 , USP18 , IFI44 , ISG20 , , EIF4E , and IFIT2 *increased* to the greatest extent in pregnant endometria ( > 8-fold log2 fold change increase ) . Positive_regulation MX2 TLR3 21130742 2372808 Cxcl10 , Mx1 , Ifi44 , Ifi203 , Iigp2 and Rtp4 were dominantly regulated by IPS-1 , Ccl5 by , and Rsad2 , [Mx2] and Cmpk2 were *regulated* by TLR3 and IPS-1 . Positive_regulation MXD1 NES 19139260 2025612 The , Xpo1p , and RanGTP are all *required* for [Mad1p] recruitment onto kinetochores in checkpoint activated cells . Positive_regulation MYB CCND1 15687240 1395454 The results suggest that [c-Myb] activity is directly *regulated* by and CDKs and imply that c-Myb activity is regulated during the cell cycle in hematopoietic cells . Positive_regulation MYBL2 CLU 10770937 707644 Thus , *activation* of by [B-MYB] may be an important step in the regulation of apoptosis in normal and diseased cells . Positive_regulation MYBL2 MIP 17098733 1676149 *regulates* the expression of [B-Myb] and the induction of cyclin A , cyclin B , and CDK1 . Positive_regulation MYC CAPN8 21293188 2393191 Here we discuss the roles and regulation of full-length Myc and Myc-nick in terminal differentiation and propose a model in which *mediated* cleavage of [Myc] operates as a functional switch . Positive_regulation MYC CCND1 23975033 2920859 Emodin ( 72 h ) treatment could up-regulate the gene expression of FASL ( p < 0.05 ) and down-regulate the gene expression of [C-MYC] ( p < 0.01 ) , but *induce* no significant changes in the gene expressions of MCL1 , GAPDH , BAX and . Positive_regulation MYC CTGF 23681229 2785476 Our studies are the first to demonstrate that reduced as an unfavorable prognosis factor *mediates* the activation of miR-18b , an oncomir directly suppresses CTGF expression , by PI3K/AKT/C-Jun and [C-Myc] and promotes cell growth of NPC . Positive_regulation MYC EPHB2 10037749 592273 Using the mitogen activated protein kinase kinase ( MEK1/2 ) inhibitor PD98059 and dominant negative forms of Ras ( N17 ) and ERK1 ( K71R ) , we found that activation of Ras and extracellular signal regulated kinase ( ) is *necessary* for colony stimulating factor-1 (CSF-1) mediated [c-Myc] expression and DNA synthetic ( S ) phase entry . Positive_regulation MYC EPHB2 15811177 1397491 Therefore , our main aim was to examine the levels of MAPK in Myc transformed cells in light of the *roles* of in cell cycle and control of [Myc] protein levels . Positive_regulation MYC EPHB2 16051824 1438640 Several MAPK regulated host transcription factors such as c-Jun , STAT1alpha , MEF2 , c-Myc , ATF-2 and c-Fos were induced early during infection , and inhibition significantly *blocked* the c-Fos , c-Jun , [c-Myc] , and STAT1alpha activation in the infected cells . Positive_regulation MYC EPHB2 16596619 1550264 These data suggest that an increase in [c-Myc] phosphorylation in *response* to prolonged phosphorylation negatively auto-regulates c-Myc gene expression , leading to the suppression of its target gene expression and cell cycle block . Positive_regulation MYC EPHB2 20101459 2319514 Our results revealed that the specific cascade inhibitor , PD98059 , significantly *attenuated* phosphorylation of [c-Myc] on Ser-62 and FasL upregulation in QBC-939 cells and these cells showed decreased cytotoxicity against Fas-sensitive Jurkat T cells . Positive_regulation MYC EPHB2 20473309 2269508 MyD88 ( myeloid differentiation primary response gene 88 ) -independent activation of by epidermal growth factor (EGF) *increased* p-ERK and [c-Myc] and restored the multiple intestinal neoplasia ( Min ) phenotype in Apc ( min/+ ) /Myd88 ( -/- ) mice . Positive_regulation MYC EPHB2 21543344 2423983 Furthermore , oncogenic KRAS repressed cellular FADD-like interleukin 1ß-converting enzyme ( FLICE ) -like inhibitory protein ( c-FLIP ) expression through activation of activated protein kinase (MAPK) mediated *activation* of [c-Myc] . Smac overcame KRAS induced cell-survival signaling by antagonizing X-linked inhibitor of apoptosis protein ( XIAP ) . Positive_regulation MYC EPHB2 22789855 2639792 Endoglin inhibits *induced* [c-Myc] and cyclin D1 expression to impede endothelial cell proliferation . Positive_regulation MYC EPHB2 22789855 2639793 We show that endoglin impedes cell growth through sustained inhibition of *induced* [c-Myc] and cyclin D1 expression in a TGF-ß independent manner . Positive_regulation MYC FOXO1 17974917 1820578 Moreover , constitutive [Myc] signaling *induces* a marked increase in nuclear levels and stimulates binding of FoxO proteins to the Arf locus . Positive_regulation MYC IFI27 11307151 804393 In culture , activation of [MYC] *induces* both sequestration of ( kip1 ) by cyclin D complexes and its subsequent proteolytic degradation . Positive_regulation MYC IFI27 12768542 1094569 Second , ACTH-R triggers cAMP/PKA mediated antimitogenic mechanisms comprised of Akt/PKB dephosphorylation/deactivation , [c-Myc] protein degradation , and ( Kip1 ) protein *induction* . Positive_regulation MYC IFI27 15367678 1294785 Adhesion of epithelial cells to the ECM failed to efficiently induce degradation of , to induce cdk2 activity , or to *induce* [Myc] and cyclin A synthesis ; Positive_regulation MYC IL1B 15739117 1383028 consistently *increased* islet NFkappaB activity and [c-Myc] , haeme-oxygenase 1 , inducible nitric oxide synthase (iNOS) , Fas , and inhibitor of NFkappaB alpha ( IkappaBalpha ) mRNA levels . Positive_regulation MYC MAP2K6 19581924 2129300 Finally , inhibition of , a downstream target of PAK-1 , *blocked* insulin stimulated nuclear beta-cat accumulation and [c-Myc] expression . Positive_regulation MYC MAP2K6 23770848 2932314 We determined that *activates* [c-Myc] to reduce the transcription of the SWI/SNF chromatin remodeling enzyme Brahma ( BRM ) . Positive_regulation MYC MSX1 15911613 1433292 *increases* [Gln3-Myc13] phosphorylation and rapamycin decreases it . Positive_regulation MYC TNF 16924232 1692194 *induced* the expression of NF-kappaB regulated gene products cyclin D1 , [c-Myc] , matrix metalloproteinase-9 , survivin , X-linked inhibitor-of-apoptosis protein ( IAP ) , IAP1 , Bcl-x ( L ) , A1/Bfl-1 and Fas associated death domain protein-like IL-1beta converting enzyme-inhibitory protein in wild-type MEF but not in PKR-/- cells . Positive_regulation MYC TNF 18287248 1896541 Flavopiridol also inhibited the *induced* induction of intercellular adhesion molecule-1 , [c-Myc] , and c-Fos , all known to mediate tumorigenesis . Positive_regulation MYC TNF 23553791 2804127 More interestingly , a long-term elevated levels of IFN-? and *result* in significantly increased susceptibility to malignant transformation in MSCs through NF?B mediated upregulation of the oncogenes c-Fos and [c-Myc.] Depletion of either IFN-? or TNF-a in OVX mice abolishes MSC impairment and the tendency toward malignant transformation with no NF?B mediated oncogene activation . Positive_regulation MYC TNF 23778143 2815371 SIRT1 was upregulated through [c-MYC] in embryonic and postnatal Pkd1-mutant mouse renal epithelial cells and tissues and could be *induced* by , which is present in cyst fluid during cyst development . Positive_regulation MYC WNT7A 17431004 1748952 *increased* trophectoderm cell proliferation as well as MSX2 ( msh homeobox 2 ) and [MYC] ( myelocytomatosis oncogene ) mRNA levels . Positive_regulation MYCN EPHB2 15064733 1244195 The inhibition of activation *reduced* MIF mediated [N-Myc] expression . Positive_regulation MYCN FOXO1 18335505 1892030 In conclusion , we identified a selected set of biologically relevant genes modulated by PAX3-FKHR , and demonstrated that *contributes* to the expression of [MYCN] and in turn MYCN collaborates with PAX3-FKHR in tumorigenesis . Positive_regulation MYCN GPNMB 22290289 2636611 overexpression *induced* the gene expressions of [N-myc] downstream regulated gene 1 ( Ndrg1 ) and maspin in PC-3 cells . Positive_regulation MYCN TNF 9690515 523046 [MycN] also increased cell death in *response* to TRAIL and , suggesting that enforced MYCN expression in general increases the susceptibility of neuroblastoma cells towards a variety of death stimuli . Positive_regulation MYCN TNFSF10 17991446 1859999 It has been reported that neuroblastoma cells with MYCN amplification are unable to start *dependent* death and [MYCN] , in concert with cytotoxic drugs , efficiently induces the mitochondrial pathway of apoptosis through oxidative mechanisms . Positive_regulation MYCN TNFSF10 9690515 523047 [MycN] also increased cell death in *response* to and TNFalpha , suggesting that enforced MYCN expression in general increases the susceptibility of neuroblastoma cells towards a variety of death stimuli . Positive_regulation MYD88 EPHB2 20473309 2269511 [MyD88] ( myeloid differentiation primary response gene 88 ) -independent *activation* of by epidermal growth factor (EGF) increased p-ERK and c-Myc and restored the multiple intestinal neoplasia ( Min ) phenotype in Apc ( min/+ ) /Myd88 ( -/- ) mice . Positive_regulation MYD88 GPR115 20697956 2323143 Tamiflu ( oseltamivir phosphate ) , pertussis toxin (PTX) , a specific inhibitor of Gai proteins of and the broad range inhibitor of matrix metalloproteinase (MMP) galardin applied to live primary BM macrophage cells completely *block* TQ-induced [MyD88/TLR4] complex formation . Positive_regulation MYD88 GPR132 20697956 2323132 Tamiflu ( oseltamivir phosphate ) , pertussis toxin (PTX) , a specific inhibitor of Gai proteins of and the broad range inhibitor of matrix metalloproteinase (MMP) galardin applied to live primary BM macrophage cells completely *block* TQ-induced [MyD88/TLR4] complex formation . Positive_regulation MYD88 GPR87 20697956 2323212 Tamiflu ( oseltamivir phosphate ) , pertussis toxin (PTX) , a specific inhibitor of Gai proteins of and the broad range inhibitor of matrix metalloproteinase (MMP) galardin applied to live primary BM macrophage cells completely *block* TQ-induced [MyD88/TLR4] complex formation . Positive_regulation MYD88 IL1B 19342688 2056863 By small interfering RNAs mediated knockdown , we show that induced up-regulation of ADAMTS-4 in chondrocytes *requires* [MyD88] , IRAK1 , and TRAF6 adaptor proteins . Positive_regulation MYD88 IL1B 19783673 2147630 however , neutrophil recruitment , the localized production of , and the increase in circulating IL-6 *require* [MyD88] signaling , the IL-1R pathway , and the inflammasome components ICE ( IL-1beta converting enzyme ) , ASC ( apoptosis associated , speck-like protein containing CARD ) , and NALP3 . Positive_regulation MYD88 TLR7 12356687 994010 can *activate* dendritic cells ( DC ) through common signaling pathways requiring a cytoplasmic adapter , [MyD88] . Positive_regulation MYD88 TLR7 16239509 1471022 We also determined that [MyD88] , IRAK , TRAF6 , and Toll interacting protein (Tollip) , but not TIRAP , were involved in the *mediated* response to P. aeruginosa in HAECs . Positive_regulation MYD88 TLR7 18772134 1985800 signaling *enhances* the interaction of [MyD88] and Trif with Beclin 1 , and reduces the binding of Beclin 1 to Bcl-2 . Positive_regulation MYD88 TLR7 19904768 2189099 [MYD88 dependent and -independent] *activation* of TREM-1 via specific ligands . Positive_regulation MYD88 TLR7 19949061 2199092 Our results indicate that chloroquine blocks *mediated* activation of pDC and [MyD88] signaling , as shown by decreases in the levels of the downstream signaling molecules IRAK-4 and IRF-7 and by inhibition of IFN-alpha synthesis . Positive_regulation MYD88 TLR7 21480215 2444145 These responses absolutely required [MyD88] , a Toll-like receptor (TLR) adaptor molecule , and were partially *dependent* on TLR9 and . Positive_regulation MYD88 TLR7 23519847 2799604 In contrast , silencing of MyD88 leads to a complete loss of cytokine secretion , indicating that IRAK4 acts as a differential regulator of *induced* cytokine secretion downstream of [MyD88] . Positive_regulation MYD88 TLR7 23831471 2824932 This suppressive effect of Atg5 may not be associated with autophagic processes because [MyD88] itself was not degraded and because stimulation did not *induce* LC3 punctate formation and LC3 conversion . Positive_regulation MYD88 TLR7 23831471 2824956 Furthermore , Atg5 deficiency increased formation of the [MyD88-TRAF6] signaling complex *induced* by stimulation , and it enhanced activation of NF-?B signaling but not MAPKs and Akt . Positive_regulation MYD88 TLR7 23843519 2816472 In cultured neurons , activation *induced* IL-6 and TNF-a expression through [Myd88] . Positive_regulation MYD88 TLR7 23845800 2825069 Collectively , these results suggest that *dependent* [MyD88] signaling is required for T cell priming during NS4B-P38G mutant infection , whereas the TLR7 independent MyD88 signaling pathways are involved in memory T cell development , which may contribute to host protection during secondary challenge with wild-type WNV . Positive_regulation MYD88 TNF 12763043 1093838 The results demonstrated three patterns of gene expression : the TLR2 and myeloid differentiation factor 88 ( [MyD88] ) gene expressions were induced in AM in *response* to lipopolysaccharide (LPS) , interleukin (IL)-1beta , or or in the lung tissue of an LPS induced acute lung injury model ; Positive_regulation MYD88 TNF 15898987 1408687 These findings indicate that the production of and IL-13 by LPS *required* [TLR4/MyD88/TRAF6] signalling as a common pathway of mast cell mediated inflammation . Positive_regulation MYD88 TNF 16936244 1673101 induction *required* [MyD88] and was absent in TLR2/4 ( -/- ) cells in response to fliC but not wild-type P. aeruginosa , whereas TLR2 ( -/- ) cells exhibited augmented responses . Positive_regulation MYD88 TNF 17403539 1735942 Trauma-hemorrhage increased the production of IL-6 , IL-10 , IL-12 and *enhanced* the expression of TLR4 , [MyD88] as well as the activation of MAPK proteins ( p38 , ERK and JNK ) in epidermal keratinocytes . Positive_regulation MYD88 TNF 19570869 2122086 In contrast , iPPVO induced release and enhanced expression of MHC-I and CD86 but not of MHC-II by BMDC chiefly *requires* [MyD88] but not TLR2 or TLR4 . Positive_regulation MYD88 TNF 19638630 2149980 Silencing of myeloid differentiation protein ( MyD88 ) and TRIF related adaptor molecule (TRAM) , using small interfering RNA abolished IL-4 induction induced by LPS whereas silencing of TRAM has no effect on TNFalpha induction , thereby indicating that LPS induced is MyD88 dependent but IL-4 is *required* both [MyD88] and TRAM . Positive_regulation MYD88 TNF 20673241 2340643 Signalling pathways triggered by TLR4 and TLR9 involve [MyD88] and are partially *mediated* by the cytokine . Positive_regulation MYD88 TNF 23843519 2816471 In cultured neurons , TLR7 activation *induced* IL-6 and expression through [Myd88] . Positive_regulation MYEF2 PGC 15111488 1241167 From these data , it appears that HDAC5 , , and p38 *regulate* [MEF-2] and could be potential targets for modulating GLUT4 expression . Positive_regulation MYF5 EPHB2 17481856 1761498 Control of [Myf5] activation in adult skeletal myonuclei *requires* signalling . Positive_regulation MYF5 ZIC2 21211521 2386300 In functional reporter assays , Zic1 and , but not Zic3 , potentiate the transactivation of Gli dependent Myf5 epaxial somite-specific ( ES ) enhancer activity in 3T3 cells , and Zic1 *activates* endogenous [Myf5] expression in 10T1/2 cells and in presomitic mesoderm explants . Positive_regulation MYF5 ZIC2 21211521 2386304 [Myf5] activation in newly forming somites is delayed in Zic2 mutant embryos until the time of Zic1 activation , and both and Myf5 *require* noggin for their activation . Positive_regulation MYF5 ZIC2 24036067 2857159 Both Glis , the downstream effectors of hedgehog signaling , and transcription factors are *required* for [Myf5] expression in the epaxial somite . Positive_regulation MYH1 TNF 9054856 417390 In addition to the TNF-alpha induced increase in the general protein synthesis , stimulation with *led* to a 2.4-fold increase in net actin protein synthesis and a 3.3-fold increase in net [myosin heavy chain] synthesis . Positive_regulation MYH10 TNF 9054856 417391 In addition to the TNF-alpha induced increase in the general protein synthesis , stimulation with *led* to a 2.4-fold increase in net actin protein synthesis and a 3.3-fold increase in net [myosin heavy chain] synthesis . Positive_regulation MYH11 JAG1 16867989 1613508 Physiological Notch stimulation by its ligand , but not Dll4 , directly *induces* [Sm-mhc] expression in 10T1/2 cells without de novo protein synthesis , indicative of a ligand-selective effect . Positive_regulation MYH11 JAG1 16867989 1613521 *induced* expression of [SM-MHC] was blocked bygamma-secretase inhibitor , N- ( N- ( 3,5-difluorophenyl ) -l-alanyl ) -S-phenylglycine t-butyl ester , which impedes Notch signaling . Positive_regulation MYH11 TNF 9054856 417392 In addition to the TNF-alpha induced increase in the general protein synthesis , stimulation with *led* to a 2.4-fold increase in net actin protein synthesis and a 3.3-fold increase in net [myosin heavy chain] synthesis . Positive_regulation MYH13 TNF 9054856 417393 In addition to the TNF-alpha induced increase in the general protein synthesis , stimulation with *led* to a 2.4-fold increase in net actin protein synthesis and a 3.3-fold increase in net [myosin heavy chain] synthesis . Positive_regulation MYH14 TNF 9054856 417387 In addition to the TNF-alpha induced increase in the general protein synthesis , stimulation with *led* to a 2.4-fold increase in net actin protein synthesis and a 3.3-fold increase in net [myosin heavy chain] synthesis . Positive_regulation MYH15 TNF 9054856 417389 In addition to the TNF-alpha induced increase in the general protein synthesis , stimulation with *led* to a 2.4-fold increase in net actin protein synthesis and a 3.3-fold increase in net [myosin heavy chain] synthesis . Positive_regulation MYH16 ACE 17188239 1680014 On the other hand , overexpression of *induced* the down-regulation of [myosin heavy chain] . Positive_regulation MYH16 ACE 17892857 1802610 Overexpression of *induced* the down-regulation of [myosin heavy chain] , a late myogenic marker at 3-5 days after induction of differentiation . Positive_regulation MYH16 AKT1 10051597 593207 Expression of constitutively active forms of dramatically *enhances* myotube formation and expression of the muscle-specific proteins MyoD , creatine kinase , [myosin heavy chain] , and desmin . Positive_regulation MYH16 AKT2 10051597 593208 Expression of constitutively active forms of dramatically *enhances* myotube formation and expression of the muscle-specific proteins MyoD , creatine kinase , [myosin heavy chain] , and desmin . Positive_regulation MYH16 AKT3 10051597 593209 Expression of constitutively active forms of dramatically *enhances* myotube formation and expression of the muscle-specific proteins MyoD , creatine kinase , [myosin heavy chain] , and desmin . Positive_regulation MYH16 ANGPT2 12016267 942317 Furthermore , *induced* the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was inhibited by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or mitogen activated protein kinase kinase 6 . Positive_regulation MYH16 ANGPT2 22345300 2571994 Caffeine and *increased* the cell surface area of cardiomyocytes and the mRNA level of atrial natriuretic peptide , brain natriuretic peptide and [ß-myosin heavy chain] , but ionomycin did not . Positive_regulation MYH16 ANGPT2 24028210 2866804 M3-mAChR overexpression significantly attenuated the increased expression of atrial natriuretic peptide and [ß-myosin heavy chain] *induced* by both in vivo and in vitro . Positive_regulation MYH16 CA2 10580427 570054 Phosphopeptide mapping suggested that the same peptide was phosphorylated under both PMA and glyceraldehyde stimulation , which further extends our previous study of the Ca2+ dependent phosphorylation of this protein ( Wilson JR , Ludowyke RI , Biden TJ : Nutrient stimulation results in a rapid *dependent* threonine phosphorylation of [myosin heavy chain] in rat pancreatic islets and RINm5F cells . Positive_regulation MYH16 CARM1 22016767 2498846 However , our results show that is *required* for proper slow [myosin heavy chain] localization . Positive_regulation MYH16 CASP3 16395406 1506139 Further , this diet prevents a number of pathologic indicators in males , including fibrosis , *induction* of [beta-myosin heavy chain] , inactivation of glycogen synthase kinase 3beta ( GSK3beta ) , and activation . Positive_regulation MYH16 CD6 2473006 113743 Transient transfection of <10T1/2> or 3T3 cells with the MyoD1 related cDNA is sufficient to *induce* [myosin heavy-chain] expression and to activate a reporter gene under transcriptional control of the muscle creatine kinase 5 ' enhancer , which functions only in differentiated myocytes . Positive_regulation MYH16 CDC7 24133205 2875093 overexpression , on the other hand , *enhances* SM [myosin heavy chain] expression . Positive_regulation MYH16 EDN1 15864745 1401428 Role of mitogen activated protein kinase pathway in reactive oxygen species mediated *induced* [beta-myosin heavy chain] gene expression and cardiomyocyte hypertrophy . Positive_regulation MYH16 EDN1 16049167 1453747 In addition , NO also significantly inhibited *stimulated* promoter activity of hypertrophic marker gene [beta-myosin heavy chain] and the enhanced protein synthesis . Positive_regulation MYH16 EGR1 2071571 162693 , a serum-inducible zinc finger protein , *regulates* transcription of the rat cardiac [alpha-myosin heavy chain] gene . Positive_regulation MYH16 GATA4 8007990 258435 *regulates* cardiac muscle-specific expression of the [alpha-myosin heavy-chain] gene . Positive_regulation MYH16 GATA5 10212267 607804 is *involved* in leukemia inhibitory factor-responsive transcription of the [beta-myosin heavy chain] gene in cardiac myocytes . Positive_regulation MYH16 GATA6 15550397 1367780 In contrast , *activated* the smooth muscle [myosin heavy chain] and smooth muscle alpha-actin promoters and had no significant effect on the SM22alpha promoter . Positive_regulation MYH16 GATA6 15550397 1367826 In contrast , and myocardin *resulted* in synergistic activation of the smooth muscle [myosin heavy chain] promoter . Positive_regulation MYH16 GATA6 16293227 1502681 To address the potential mechanisms by which CHF1/Hey2 regulates vascular smooth-muscle phenotype switching , we investigated the effect of CHF1/Hey2 on *dependent* smooth-muscle [myosin heavy chain] promoter activity . Positive_regulation MYH16 GH1 2497466 109753 Recombinant *enhances* muscle [myosin heavy-chain] mRNA accumulation and amino acid accrual in humans . Positive_regulation MYH16 HDAC1 16380549 1505479 The expressions of atrial natriuretic factor , alpha-tubulin , [beta-myosin heavy chain] , and interstitial fibrosis were *reduced* by inhibition . Positive_regulation MYH16 HDAC2 16380549 1505480 The expressions of atrial natriuretic factor , alpha-tubulin , [beta-myosin heavy chain] , and interstitial fibrosis were *reduced* by inhibition . Positive_regulation MYH16 HOXA10 15886193 1426567 directly activated the smooth muscle-specific telokin promoter but did not *activate* the SM22alpha , smooth muscle alpha-actin , or smooth muscle [myosin heavy chain] promoters . Positive_regulation MYH16 HRAS 19625607 2142881 Different *roles* of for regulation of [myosin heavy chain] promoters in satellite cell derived muscle cell culture during proliferation and differentiation . Positive_regulation MYH16 IGF1 19657059 2143651 *activates* the mouse type IIb [myosin heavy chain] gene . Positive_regulation MYH16 IGF1 9886960 584910 *stimulates* cardiac [myosin heavy chain] and actin synthesis in the awake rat . Positive_regulation MYH16 ILK 10953009 724216 Overexpression of in the myoblasts *inhibited* the expression of myogenic proteins ( myogenin , MyoD , and [myosin heavy chain] ) and the subsequent formation of multinucleated myotubes . Positive_regulation MYH16 KLF15 24680826 2935081 *regulates* slow [myosin heavy chain] expression through NFATc1 in C2C12 myotubes . Positive_regulation MYH16 LIF 10212267 607836 The present study investigated the transcriptional pathways by which *activates* [beta-myosin heavy chain] expression during myocardial cell hypertrophy . Positive_regulation MYH16 MAPK3 18650426 1960262 A thrombin-inducible expression of smooth muscle-specific alpha-actin and [myosin heavy chain] *requires* transactivation of the epidermal growth factor (EGF) receptor and a biphasic activation of . Positive_regulation MYH16 MIR27A 21149577 2378412 *regulates* beta cardiac [myosin heavy chain] gene expression by targeting thyroid hormone receptor beta1 in neonatal rat ventricular myocytes . Positive_regulation MYH16 MMP9 10937947 580694 Altered balance between matrix gelatinases ( MMP-2 and MMP-9 ) and their tissue inhibitors in human dilated cardiomyopathy : potential *role* of in [myosin-heavy chain] degradation . Positive_regulation MYH16 MSH2 20223032 1506436 The MYH gene product is involved in DNA repair and indeed the complex ( both genes being essential elements of the DNA mismatch repair pathway ) is *required* to stimulate [MYH] activity . Positive_regulation MYH16 MSH2 20223032 1506492 We reasoned that because of the clinical similarity of a subset of HNPCC patients to those described with MYH mutations and the *role* of the complex in the activation of [MYH] protein that MYH mutations may account for a small proportion of HNPCC patients . Positive_regulation MYH16 MSH6 20223032 1506437 The MYH gene product is involved in DNA repair and indeed the complex ( both genes being essential elements of the DNA mismatch repair pathway ) is *required* to stimulate [MYH] activity . Positive_regulation MYH16 MSH6 20223032 1506493 We reasoned that because of the clinical similarity of a subset of HNPCC patients to those described with MYH mutations and the *role* of the complex in the activation of [MYH] protein that MYH mutations may account for a small proportion of HNPCC patients . Positive_regulation MYH16 MSTN 22910409 2672240 Interestingly , Mstn knockout led to a shift of Myh towards faster isoforms , suggesting an inhibitory *role* of in fast [Myh] expression . Positive_regulation MYH16 MTPN 9633917 513163 Pretreatment of myocytes with staurosporine also reduced the *induced* mRNA levels of c-fos and [beta-myosin heavy chain] . Positive_regulation MYH16 MYEF2 17111365 1693294 *Activation* of the beta [myosin heavy chain] promoter by , MyoD , p300 , and the calcineurin/NFATc1 pathway . Positive_regulation MYH16 MYEF2 8366095 229284 Myocyte-specific enhancer binding factor ( ) *regulates* alpha-cardiac [myosin heavy chain] gene expression in vitro and in vivo . Positive_regulation MYH16 MYEF2 8449897 214058 *Role* of myocyte-specific enhancer binding factor ( ) in transcriptional regulation of the alpha-cardiac [myosin heavy chain] gene . Positive_regulation MYH16 MYF5 16584724 1568587 MyoD , , and the calcineurin pathway *activate* the developmental [myosin heavy chain] genes . Positive_regulation MYH16 MYOCD 15550397 1367825 In contrast , GATA-6 and *resulted* in synergistic activation of the smooth muscle [myosin heavy chain] promoter . Positive_regulation MYH16 NPY 12007917 940668 *increased* expression of the constitutive gene , myosin light chain-2 (MLC-2) , maximally at 12 h ( 4.7-fold > basal ) but did not induce ( t < or = 36 h ) expression of foetal genes ( atrial natriuretic peptide (ANP) , skeletal-alpha-actin and [myosin heavy chain-beta] ) . Positive_regulation MYH16 PDZRN3 17118964 1661146 Depletion of by RNA interference *inhibited* the formation of myotubes as well as the associated up-regulation of [myosin heavy chain] in C2C12 cells . Positive_regulation MYH16 PITX2 21727215 2476135 *regulates* [myosin heavy chain] isoform expression and multi-innervation in extraocular muscle . Positive_regulation MYH16 PPP3CA 12016267 942318 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by inhibitors but not by the dominant negative mutants of MEF2A or mitogen activated protein kinase kinase 6 . Positive_regulation MYH16 PPP3CA 16424085 1554240 Expression of slow [myosin heavy chain] during muscle regeneration is not always *dependent* on muscle innervation and phosphatase activity . Positive_regulation MYH16 PPP3CB 12016267 942319 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by inhibitors but not by the dominant negative mutants of MEF2A or mitogen activated protein kinase kinase 6 . Positive_regulation MYH16 PPP3CB 16424085 1554241 Expression of slow [myosin heavy chain] during muscle regeneration is not always *dependent* on muscle innervation and phosphatase activity . Positive_regulation MYH16 PPP3CC 12016267 942320 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by inhibitors but not by the dominant negative mutants of MEF2A or mitogen activated protein kinase kinase 6 . Positive_regulation MYH16 PPP3CC 16424085 1554242 Expression of slow [myosin heavy chain] during muscle regeneration is not always *dependent* on muscle innervation and phosphatase activity . Positive_regulation MYH16 QRICH1 7733273 302464 *prevents* downregulation of [myosin heavy chain] synthesis and muscle atrophy from glucocorticoids . Positive_regulation MYH16 QRICH2 7733273 302465 *prevents* downregulation of [myosin heavy chain] synthesis and muscle atrophy from glucocorticoids . Positive_regulation MYH16 RALGDS 12642511 1072267 Transfection of and constitutively active mutant of Ral ( RalG23V ) in cultured rat neonatal myocytes *stimulated* promoter activity of c-fos ( 5.4-fold and 2.6-fold , P < 0.01 ) , alpha-skeletal actin ( 2.7-fold and 2.1-fold , P < 0.01 ) , and [beta-myosin heavy chain-luciferase] ( 2.8-fold and 2.3-fold , P < 0.01 ) . Positive_regulation MYH16 RBBP4 16380549 1505481 The expressions of atrial natriuretic factor , alpha-tubulin , [beta-myosin heavy chain] , and interstitial fibrosis were *reduced* by inhibition . Positive_regulation MYH16 RBBP7 16380549 1505482 The expressions of atrial natriuretic factor , alpha-tubulin , [beta-myosin heavy chain] , and interstitial fibrosis were *reduced* by inhibition . Positive_regulation MYH16 RGCC 17327222 1719921 Moreover , overexpression significantly *enhanced* TGF-beta induced alpha-SMA , SM22alpha , and SM [myosin heavy chain] promoter activities in both Monc-1 and C3H10T1/2 cells . Positive_regulation MYH16 SRF 15950986 1440588 Using this approach , we demonstrate that is *required* for the induction of atrial naturetic factor ( ANF ) , c-fos , NCX1 , BNP , alpha-actins , [alpha-myosin heavy chain] , and beta-myosin heavy chain genes . Positive_regulation MYH16 ST3GAL4 24012810 2937957 Gel electrophoresis showed that *increased* the relative expression of ß [myosin heavy chain] . Positive_regulation MYH16 TAC1 23986715 2833133 reduced expression of the sarcoplasmic reticulum Ca ( 2+ ) -ATPase ( 2a ) ( SERCA2a ; 2 and 9 weeks ) and phospholamban ( PLN ; 2 weeks ) but *increased* PLN phosphorylation ( 2 weeks ) and [ß-myosin heavy chain] ( ß-MyHC ; 9 weeks ) in WT hearts . Positive_regulation MYH16 TAC3 23986715 2833134 reduced expression of the sarcoplasmic reticulum Ca ( 2+ ) -ATPase ( 2a ) ( SERCA2a ; 2 and 9 weeks ) and phospholamban ( PLN ; 2 weeks ) but *increased* PLN phosphorylation ( 2 weeks ) and [ß-myosin heavy chain] ( ß-MyHC ; 9 weeks ) in WT hearts . Positive_regulation MYH16 TAC4 23986715 2833135 reduced expression of the sarcoplasmic reticulum Ca ( 2+ ) -ATPase ( 2a ) ( SERCA2a ; 2 and 9 weeks ) and phospholamban ( PLN ; 2 weeks ) but *increased* PLN phosphorylation ( 2 weeks ) and [ß-myosin heavy chain] ( ß-MyHC ; 9 weeks ) in WT hearts . Positive_regulation MYH16 TGFB1 8166645 254903 *prevented* the loss of smooth-muscle-specific [myosin heavy chain] ( SM-MHC ) , which occurs in primary VSMC cultures in the presence or absence of serum , and the cells proliferated while maintaining a differentiated phenotype . Positive_regulation MYH16 TNF 9054856 417388 In addition to the TNF-alpha induced increase in the general protein synthesis , stimulation with *led* to a 2.4-fold increase in net actin protein synthesis and a 3.3-fold increase in net [myosin heavy chain] synthesis . Positive_regulation MYH16 TNFSF12 20724600 2323801 Conversely , muscle-specific transgenic overexpression of *reduced* the fiber cross-sectional area and levels of the embryonic [myosin heavy chain] in regenerating muscle . Positive_regulation MYH16 VCAM1 9890996 585624 The expression of smooth muscle [myosin heavy chain] , a SMC marker , and VCAM-1 was *induced* concomitantly in serum-free medium , whereas only expression was induced by cytokine-treatment . Positive_regulation MYH2 TNF 9054856 417394 In addition to the TNF-alpha induced increase in the general protein synthesis , stimulation with *led* to a 2.4-fold increase in net actin protein synthesis and a 3.3-fold increase in net [myosin heavy chain] synthesis . Positive_regulation MYH3 ACE 17188239 1680021 On the other hand , overexpression of *induced* the down-regulation of [myosin heavy chain] . Positive_regulation MYH3 ACE 17892857 1802617 Overexpression of *induced* the down-regulation of [myosin heavy chain] , a late myogenic marker at 3-5 days after induction of differentiation . Positive_regulation MYH3 AKT1 10051597 593228 Expression of constitutively active forms of dramatically *enhances* myotube formation and expression of the muscle-specific proteins MyoD , creatine kinase , [myosin heavy chain] , and desmin . Positive_regulation MYH3 AKT2 10051597 593229 Expression of constitutively active forms of dramatically *enhances* myotube formation and expression of the muscle-specific proteins MyoD , creatine kinase , [myosin heavy chain] , and desmin . Positive_regulation MYH3 AKT3 10051597 593230 Expression of constitutively active forms of dramatically *enhances* myotube formation and expression of the muscle-specific proteins MyoD , creatine kinase , [myosin heavy chain] , and desmin . Positive_regulation MYH3 ANGPT2 12016267 942359 Furthermore , *induced* the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was inhibited by calcineurin inhibitors but not by the dominant negative mutants of MEF2A or mitogen activated protein kinase kinase 6 . Positive_regulation MYH3 ANGPT2 22345300 2572001 Caffeine and *increased* the cell surface area of cardiomyocytes and the mRNA level of atrial natriuretic peptide , brain natriuretic peptide and [ß-myosin heavy chain] , but ionomycin did not . Positive_regulation MYH3 ANGPT2 24028210 2866811 M3-mAChR overexpression significantly attenuated the increased expression of atrial natriuretic peptide and [ß-myosin heavy chain] *induced* by both in vivo and in vitro . Positive_regulation MYH3 CA2 10580427 570061 Phosphopeptide mapping suggested that the same peptide was phosphorylated under both PMA and glyceraldehyde stimulation , which further extends our previous study of the Ca2+ dependent phosphorylation of this protein ( Wilson JR , Ludowyke RI , Biden TJ : Nutrient stimulation results in a rapid *dependent* threonine phosphorylation of [myosin heavy chain] in rat pancreatic islets and RINm5F cells . Positive_regulation MYH3 CARM1 22016767 2498853 However , our results show that is *required* for proper slow [myosin heavy chain] localization . Positive_regulation MYH3 CASP3 16395406 1506146 Further , this diet prevents a number of pathologic indicators in males , including fibrosis , *induction* of [beta-myosin heavy chain] , inactivation of glycogen synthase kinase 3beta ( GSK3beta ) , and activation . Positive_regulation MYH3 CD6 2473006 113750 Transient transfection of <10T1/2> or 3T3 cells with the MyoD1 related cDNA is sufficient to *induce* [myosin heavy-chain] expression and to activate a reporter gene under transcriptional control of the muscle creatine kinase 5 ' enhancer , which functions only in differentiated myocytes . Positive_regulation MYH3 CDC7 24133205 2875100 overexpression , on the other hand , *enhances* SM [myosin heavy chain] expression . Positive_regulation MYH3 EDN1 15864745 1401435 Role of mitogen activated protein kinase pathway in reactive oxygen species mediated *induced* [beta-myosin heavy chain] gene expression and cardiomyocyte hypertrophy . Positive_regulation MYH3 EDN1 16049167 1453754 In addition , NO also significantly inhibited *stimulated* promoter activity of hypertrophic marker gene [beta-myosin heavy chain] and the enhanced protein synthesis . Positive_regulation MYH3 EGR1 2071571 162700 , a serum-inducible zinc finger protein , *regulates* transcription of the rat cardiac [alpha-myosin heavy chain] gene . Positive_regulation MYH3 GATA4 8007990 258442 *regulates* cardiac muscle-specific expression of the [alpha-myosin heavy-chain] gene . Positive_regulation MYH3 GATA5 10212267 607812 is *involved* in leukemia inhibitory factor-responsive transcription of the [beta-myosin heavy chain] gene in cardiac myocytes . Positive_regulation MYH3 GATA6 15550397 1367787 In contrast , *activated* the smooth muscle [myosin heavy chain] and smooth muscle alpha-actin promoters and had no significant effect on the SM22alpha promoter . Positive_regulation MYH3 GATA6 15550397 1367840 In contrast , and myocardin *resulted* in synergistic activation of the smooth muscle [myosin heavy chain] promoter . Positive_regulation MYH3 GATA6 16293227 1502688 To address the potential mechanisms by which CHF1/Hey2 regulates vascular smooth-muscle phenotype switching , we investigated the effect of CHF1/Hey2 on *dependent* smooth-muscle [myosin heavy chain] promoter activity . Positive_regulation MYH3 GH1 2497466 109760 Recombinant *enhances* muscle [myosin heavy-chain] mRNA accumulation and amino acid accrual in humans . Positive_regulation MYH3 HDAC1 16380549 1505507 The expressions of atrial natriuretic factor , alpha-tubulin , [beta-myosin heavy chain] , and interstitial fibrosis were *reduced* by inhibition . Positive_regulation MYH3 HDAC2 16380549 1505508 The expressions of atrial natriuretic factor , alpha-tubulin , [beta-myosin heavy chain] , and interstitial fibrosis were *reduced* by inhibition . Positive_regulation MYH3 HOXA10 15886193 1426574 directly activated the smooth muscle-specific telokin promoter but did not *activate* the SM22alpha , smooth muscle alpha-actin , or smooth muscle [myosin heavy chain] promoters . Positive_regulation MYH3 HRAS 19625607 2142888 Different *roles* of for regulation of [myosin heavy chain] promoters in satellite cell derived muscle cell culture during proliferation and differentiation . Positive_regulation MYH3 IGF1 19657059 2143658 *activates* the mouse type IIb [myosin heavy chain] gene . Positive_regulation MYH3 IGF1 9886960 584917 *stimulates* cardiac [myosin heavy chain] and actin synthesis in the awake rat . Positive_regulation MYH3 ILK 10953009 724223 Overexpression of in the myoblasts *inhibited* the expression of myogenic proteins ( myogenin , MyoD , and [myosin heavy chain] ) and the subsequent formation of multinucleated myotubes . Positive_regulation MYH3 KLF15 24680826 2935088 *regulates* slow [myosin heavy chain] expression through NFATc1 in C2C12 myotubes . Positive_regulation MYH3 LIF 10212267 607843 The present study investigated the transcriptional pathways by which *activates* [beta-myosin heavy chain] expression during myocardial cell hypertrophy . Positive_regulation MYH3 MAPK3 18650426 1960285 A thrombin-inducible expression of smooth muscle-specific alpha-actin and [myosin heavy chain] *requires* transactivation of the epidermal growth factor (EGF) receptor and a biphasic activation of . Positive_regulation MYH3 MIR27A 21149577 2378419 *regulates* beta cardiac [myosin heavy chain] gene expression by targeting thyroid hormone receptor beta1 in neonatal rat ventricular myocytes . Positive_regulation MYH3 MMP9 10937947 580701 Altered balance between matrix gelatinases ( MMP-2 and MMP-9 ) and their tissue inhibitors in human dilated cardiomyopathy : potential *role* of in [myosin-heavy chain] degradation . Positive_regulation MYH3 MSH2 20223032 1506450 The MYH gene product is involved in DNA repair and indeed the complex ( both genes being essential elements of the DNA mismatch repair pathway ) is *required* to stimulate [MYH] activity . Positive_regulation MYH3 MSH2 20223032 1506506 We reasoned that because of the clinical similarity of a subset of HNPCC patients to those described with MYH mutations and the *role* of the complex in the activation of [MYH] protein that MYH mutations may account for a small proportion of HNPCC patients . Positive_regulation MYH3 MSH6 20223032 1506451 The MYH gene product is involved in DNA repair and indeed the complex ( both genes being essential elements of the DNA mismatch repair pathway ) is *required* to stimulate [MYH] activity . Positive_regulation MYH3 MSH6 20223032 1506507 We reasoned that because of the clinical similarity of a subset of HNPCC patients to those described with MYH mutations and the *role* of the complex in the activation of [MYH] protein that MYH mutations may account for a small proportion of HNPCC patients . Positive_regulation MYH3 MSTN 22910409 2672247 Interestingly , Mstn knockout led to a shift of Myh towards faster isoforms , suggesting an inhibitory *role* of in fast [Myh] expression . Positive_regulation MYH3 MTPN 9633917 513170 Pretreatment of myocytes with staurosporine also reduced the *induced* mRNA levels of c-fos and [beta-myosin heavy chain] . Positive_regulation MYH3 MYEF2 17111365 1693301 *Activation* of the beta [myosin heavy chain] promoter by , MyoD , p300 , and the calcineurin/NFATc1 pathway . Positive_regulation MYH3 MYEF2 8366095 229291 Myocyte-specific enhancer binding factor ( ) *regulates* alpha-cardiac [myosin heavy chain] gene expression in vitro and in vivo . Positive_regulation MYH3 MYEF2 8449897 214065 *Role* of myocyte-specific enhancer binding factor ( ) in transcriptional regulation of the alpha-cardiac [myosin heavy chain] gene . Positive_regulation MYH3 MYF5 16584724 1568594 MyoD , , and the calcineurin pathway *activate* the developmental [myosin heavy chain] genes . Positive_regulation MYH3 MYOCD 15550397 1367839 In contrast , GATA-6 and *resulted* in synergistic activation of the smooth muscle [myosin heavy chain] promoter . Positive_regulation MYH3 NPY 12007917 940675 *increased* expression of the constitutive gene , myosin light chain-2 (MLC-2) , maximally at 12 h ( 4.7-fold > basal ) but did not induce ( t < or = 36 h ) expression of foetal genes ( atrial natriuretic peptide (ANP) , skeletal-alpha-actin and [myosin heavy chain-beta] ) . Positive_regulation MYH3 PDZRN3 17118964 1661153 Depletion of by RNA interference *inhibited* the formation of myotubes as well as the associated up-regulation of [myosin heavy chain] in C2C12 cells . Positive_regulation MYH3 PITX2 21727215 2476142 *regulates* [myosin heavy chain] isoform expression and multi-innervation in extraocular muscle . Positive_regulation MYH3 PPP3CA 12016267 942360 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by inhibitors but not by the dominant negative mutants of MEF2A or mitogen activated protein kinase kinase 6 . Positive_regulation MYH3 PPP3CA 16424085 1554261 Expression of slow [myosin heavy chain] during muscle regeneration is not always *dependent* on muscle innervation and phosphatase activity . Positive_regulation MYH3 PPP3CB 12016267 942361 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by inhibitors but not by the dominant negative mutants of MEF2A or mitogen activated protein kinase kinase 6 . Positive_regulation MYH3 PPP3CB 16424085 1554262 Expression of slow [myosin heavy chain] during muscle regeneration is not always *dependent* on muscle innervation and phosphatase activity . Positive_regulation MYH3 PPP3CC 12016267 942362 Furthermore , Ang II induced the promoter activity of the nonmuscle-type [myosin heavy chain] B gene , which we used as a marker of the dedifferentiated state of VSMCs , and this increase was *inhibited* by inhibitors but not by the dominant negative mutants of MEF2A or mitogen activated protein kinase kinase 6 . Positive_regulation MYH3 PPP3CC 16424085 1554263 Expression of slow [myosin heavy chain] during muscle regeneration is not always *dependent* on muscle innervation and phosphatase activity . Positive_regulation MYH3 QRICH1 7733273 302478 *prevents* downregulation of [myosin heavy chain] synthesis and muscle atrophy from glucocorticoids . Positive_regulation MYH3 QRICH2 7733273 302479 *prevents* downregulation of [myosin heavy chain] synthesis and muscle atrophy from glucocorticoids . Positive_regulation MYH3 RALGDS 12642511 1072274 Transfection of and constitutively active mutant of Ral ( RalG23V ) in cultured rat neonatal myocytes *stimulated* promoter activity of c-fos ( 5.4-fold and 2.6-fold , P < 0.01 ) , alpha-skeletal actin ( 2.7-fold and 2.1-fold , P < 0.01 ) , and [beta-myosin heavy chain-luciferase] ( 2.8-fold and 2.3-fold , P < 0.01 ) . Positive_regulation MYH3 RBBP4 16380549 1505509 The expressions of atrial natriuretic factor , alpha-tubulin , [beta-myosin heavy chain] , and interstitial fibrosis were *reduced* by inhibition . Positive_regulation MYH3 RBBP7 16380549 1505510 The expressions of atrial natriuretic factor , alpha-tubulin , [beta-myosin heavy chain] , and interstitial fibrosis were *reduced* by inhibition . Positive_regulation MYH3 RGCC 17327222 1719928 Moreover , overexpression significantly *enhanced* TGF-beta induced alpha-SMA , SM22alpha , and SM [myosin heavy chain] promoter activities in both Monc-1 and C3H10T1/2 cells . Positive_regulation MYH3 SRF 15950986 1440595 Using this approach , we demonstrate that is *required* for the induction of atrial naturetic factor ( ANF ) , c-fos , NCX1 , BNP , alpha-actins , [alpha-myosin heavy chain] , and beta-myosin heavy chain genes . Positive_regulation MYH3 ST3GAL4 24012810 2937964 Gel electrophoresis showed that *increased* the relative expression of ß [myosin heavy chain] . Positive_regulation MYH3 TAC1 23986715 2833154 reduced expression of the sarcoplasmic reticulum Ca ( 2+ ) -ATPase ( 2a ) ( SERCA2a ; 2 and 9 weeks ) and phospholamban ( PLN ; 2 weeks ) but *increased* PLN phosphorylation ( 2 weeks ) and [ß-myosin heavy chain] ( ß-MyHC ; 9 weeks ) in WT hearts . Positive_regulation MYH3 TAC3 23986715 2833155 reduced expression of the sarcoplasmic reticulum Ca ( 2+ ) -ATPase ( 2a ) ( SERCA2a ; 2 and 9 weeks ) and phospholamban ( PLN ; 2 weeks ) but *increased* PLN phosphorylation ( 2 weeks ) and [ß-myosin heavy chain] ( ß-MyHC ; 9 weeks ) in WT hearts . Positive_regulation MYH3 TAC4 23986715 2833156 reduced expression of the sarcoplasmic reticulum Ca ( 2+ ) -ATPase ( 2a ) ( SERCA2a ; 2 and 9 weeks ) and phospholamban ( PLN ; 2 weeks ) but *increased* PLN phosphorylation ( 2 weeks ) and [ß-myosin heavy chain] ( ß-MyHC ; 9 weeks ) in WT hearts . Positive_regulation MYH3 TGFB1 8166645 254910 *prevented* the loss of smooth-muscle-specific [myosin heavy chain] ( SM-MHC ) , which occurs in primary VSMC cultures in the presence or absence of serum , and the cells proliferated while maintaining a differentiated phenotype . Positive_regulation MYH3 TNF 9054856 417395 In addition to the TNF-alpha induced increase in the general protein synthesis , stimulation with *led* to a 2.4-fold increase in net actin protein synthesis and a 3.3-fold increase in net [myosin heavy chain] synthesis . Positive_regulation MYH3 TNFSF12 20724600 2323808 Conversely , muscle-specific transgenic overexpression of *reduced* the fiber cross-sectional area and levels of the embryonic [myosin heavy chain] in regenerating muscle . Positive_regulation MYH3 VCAM1 9890996 585631 The expression of smooth muscle [myosin heavy chain] , a SMC marker , and VCAM-1 was *induced* concomitantly in serum-free medium , whereas only expression was induced by cytokine-treatment . Positive_regulation MYH4 TNF 9054856 417396 In addition to the TNF-alpha induced increase in the general protein synthesis , stimulation with *led* to a 2.4-fold increase in net actin protein synthesis and a 3.3-fold increase in net [myosin heavy chain] synthesis . Positive_regulation MYH6 TNF 9054856 417397 In addition to the TNF-alpha induced increase in the general protein synthesis , stimulation with *led* to a 2.4-fold increase in net actin protein synthesis and a 3.3-fold increase in net [myosin heavy chain] synthesis . Positive_regulation MYH7 TNF 9054856 417398 In addition to the TNF-alpha induced increase in the general protein synthesis , stimulation with *led* to a 2.4-fold increase in net actin protein synthesis and a 3.3-fold increase in net [myosin heavy chain] synthesis . Positive_regulation MYH8 TNF 9054856 417399 In addition to the TNF-alpha induced increase in the general protein synthesis , stimulation with *led* to a 2.4-fold increase in net actin protein synthesis and a 3.3-fold increase in net [myosin heavy chain] synthesis . Positive_regulation MYH9 TNF 9054856 417400 In addition to the TNF-alpha induced increase in the general protein synthesis , stimulation with *led* to a 2.4-fold increase in net actin protein synthesis and a 3.3-fold increase in net [myosin heavy chain] synthesis . Positive_regulation MYL1 EPHB2 10477763 643325 signaling is independent of CAS/Crk coupling and *regulates* [myosin light chain] phosphorylation leading to actin-myosin assembly during cell migration and cell mediated contraction of a collagen matrix . Positive_regulation MYL1 EPHB2 15665049 1402430 The present study tested the hypothesis that and PKC differentially *regulated* [myosin light chain] phosphatase activity by phosphorylation of myosin phosphatase target protein-1 ( MYPT-1 ) and CPI-17 . Positive_regulation MYL1 EPHB2 19179620 2049210 [Myosin light chain] activation by strain *required* FAK , Rac1 , PI3K , AKT , GSK , and but not Src or p38 . Positive_regulation MYL1 MAP2K6 17429073 1742411 In cultured endothelial cells , induction of [myosin light chain] phosphorylation by PAK is *mediated* by and extracellular signal regulated kinase ( Erk ) . Positive_regulation MYL1 SLC6A2 23184663 2723838 Importantly , we demonstrate that Net1A , but not , is *required* for cell spreading on collagen , [myosin light chain] phosphorylation , and focal adhesion maturation . Positive_regulation MYL1 SLC6A2 23792411 2824266 Importantly , plasma membrane localization of is *required* for efficient [myosin light chain] phosphorylation , focal adhesion maturation , and cell spreading . Positive_regulation MYL1 SNCAIP 10788802 689006 *induced* FAK tyrosine phosphorylation , [myosin light chain] phosphorylation , and the formation of stress fibers in HUVECs . Positive_regulation MYL1 SPHK1 17164439 1717003 Overexpressing human in these cells *resulted* in increased levels of the cell cycle regulator cyclin D1 and increased [myosin light-chain] phosphorylation . Positive_regulation MYL1 TNF 17476691 1772274 rapidly *induced* RhoA activation and [myosin light chain] phosphorylation , but caused only small changes to cortical F-actin , without significantly increasing paracellular permeability up to 30 min after stimulation . Positive_regulation MYL10 EPHB2 10477763 643324 signaling is independent of CAS/Crk coupling and *regulates* [myosin light chain] phosphorylation leading to actin-myosin assembly during cell migration and cell mediated contraction of a collagen matrix . Positive_regulation MYL10 EPHB2 15665049 1402429 The present study tested the hypothesis that and PKC differentially *regulated* [myosin light chain] phosphatase activity by phosphorylation of myosin phosphatase target protein-1 ( MYPT-1 ) and CPI-17 . Positive_regulation MYL10 EPHB2 19179620 2049197 [Myosin light chain] activation by strain *required* FAK , Rac1 , PI3K , AKT , GSK , and but not Src or p38 . Positive_regulation MYL10 MAP2K6 17429073 1742398 In cultured endothelial cells , induction of [myosin light chain] phosphorylation by PAK is *mediated* by and extracellular signal regulated kinase ( Erk ) . Positive_regulation MYL10 SLC6A2 23184663 2723837 Importantly , we demonstrate that , but not Net1 , is *required* for cell spreading on collagen , [myosin light chain] phosphorylation , and focal adhesion maturation . Positive_regulation MYL10 SLC6A2 23792411 2824265 Importantly , plasma membrane localization of is *required* for efficient [myosin light chain] phosphorylation , focal adhesion maturation , and cell spreading . Positive_regulation MYL10 SNCAIP 10788802 689005 *induced* FAK tyrosine phosphorylation , [myosin light chain] phosphorylation , and the formation of stress fibers in HUVECs . Positive_regulation MYL10 SPHK1 17164439 1717002 Overexpressing human in these cells *resulted* in increased levels of the cell cycle regulator cyclin D1 and increased [myosin light-chain] phosphorylation . Positive_regulation MYL10 TNF 17476691 1772272 rapidly *induced* RhoA activation and [myosin light chain] phosphorylation , but caused only small changes to cortical F-actin , without significantly increasing paracellular permeability up to 30 min after stimulation . Positive_regulation MYL12B TNF 12606782 1062989 In permeabilized cultured guinea pig ASM cells , recombinant human *stimulated* an increase in Ca ( 2+ ) -activated [MLC(20)] phosphorylation under Ca ( 2+ ) `` clamp '' conditions . Positive_regulation MYL12B TNF 19420112 2106637 Caspase inhibition also reduced *induced* [myosin light chain (MLC)-2] phosphorylation , and activation of upstream regulator RhoA . Positive_regulation MYL2 EPHB2 10477763 643326 signaling is independent of CAS/Crk coupling and *regulates* [myosin light chain] phosphorylation leading to actin-myosin assembly during cell migration and cell mediated contraction of a collagen matrix . Positive_regulation MYL2 EPHB2 15665049 1402431 The present study tested the hypothesis that and PKC differentially *regulated* [myosin light chain] phosphatase activity by phosphorylation of myosin phosphatase target protein-1 ( MYPT-1 ) and CPI-17 . Positive_regulation MYL2 EPHB2 19179620 2049214 [Myosin light chain] activation by strain *required* FAK , Rac1 , PI3K , AKT , GSK , and but not Src or p38 . Positive_regulation MYL2 MAP2K6 17429073 1742424 In cultured endothelial cells , induction of [myosin light chain] phosphorylation by PAK is *mediated* by and extracellular signal regulated kinase ( Erk ) . Positive_regulation MYL2 MMP28 19961849 2204145 Further , drug *induced* effects on actin cytoskeletal organization , cell adhesions , [myosin II] phosphorylation , activity , and cytoskeletal protein profile in porcine trabecular meshwork ( TM ) cells were determined by immunofluorescence , zymography , and mass spectrometry . Positive_regulation MYL2 MMP7 19961849 2204160 Further , drug *induced* effects on actin cytoskeletal organization , cell adhesions , [myosin II] phosphorylation , activity , and cytoskeletal protein profile in porcine trabecular meshwork ( TM ) cells were determined by immunofluorescence , zymography , and mass spectrometry . Positive_regulation MYL2 SLC6A2 23184663 2723839 Importantly , we demonstrate that , but not Net1 , is *required* for cell spreading on collagen , [myosin light chain] phosphorylation , and focal adhesion maturation . Positive_regulation MYL2 SLC6A2 23792411 2824267 Importantly , plasma membrane localization of is *required* for efficient [myosin light chain] phosphorylation , focal adhesion maturation , and cell spreading . Positive_regulation MYL2 SNCAIP 10788802 689007 *induced* FAK tyrosine phosphorylation , [myosin light chain] phosphorylation , and the formation of stress fibers in HUVECs . Positive_regulation MYL2 SPHK1 17164439 1717004 Overexpressing human in these cells *resulted* in increased levels of the cell cycle regulator cyclin D1 and increased [myosin light-chain] phosphorylation . Positive_regulation MYL2 TNF 17476691 1772275 rapidly *induced* RhoA activation and [myosin light chain] phosphorylation , but caused only small changes to cortical F-actin , without significantly increasing paracellular permeability up to 30 min after stimulation . Positive_regulation MYL3 EPHB2 10477763 643327 signaling is independent of CAS/Crk coupling and *regulates* [myosin light chain] phosphorylation leading to actin-myosin assembly during cell migration and cell mediated contraction of a collagen matrix . Positive_regulation MYL3 EPHB2 15665049 1402432 The present study tested the hypothesis that and PKC differentially *regulated* [myosin light chain] phosphatase activity by phosphorylation of myosin phosphatase target protein-1 ( MYPT-1 ) and CPI-17 . Positive_regulation MYL3 EPHB2 19179620 2049218 [Myosin light chain] activation by strain *required* FAK , Rac1 , PI3K , AKT , GSK , and but not Src or p38 . Positive_regulation MYL3 MAP2K6 17429073 1742437 In cultured endothelial cells , induction of [myosin light chain] phosphorylation by PAK is *mediated* by and extracellular signal regulated kinase ( Erk ) . Positive_regulation MYL3 SLC6A2 23184663 2723840 Importantly , we demonstrate that Net1A , but not , is *required* for cell spreading on collagen , [myosin light chain] phosphorylation , and focal adhesion maturation . Positive_regulation MYL3 SLC6A2 23792411 2824268 Importantly , plasma membrane localization of is *required* for efficient [myosin light chain] phosphorylation , focal adhesion maturation , and cell spreading . Positive_regulation MYL3 SNCAIP 10788802 689008 *induced* FAK tyrosine phosphorylation , [myosin light chain] phosphorylation , and the formation of stress fibers in HUVECs . Positive_regulation MYL3 SPHK1 17164439 1717005 Overexpressing human in these cells *resulted* in increased levels of the cell cycle regulator cyclin D1 and increased [myosin light-chain] phosphorylation . Positive_regulation MYL3 TNF 17476691 1772276 rapidly *induced* RhoA activation and [myosin light chain] phosphorylation , but caused only small changes to cortical F-actin , without significantly increasing paracellular permeability up to 30 min after stimulation . Positive_regulation MYL4 EPHB2 10477763 643328 signaling is independent of CAS/Crk coupling and *regulates* [myosin light chain] phosphorylation leading to actin-myosin assembly during cell migration and cell mediated contraction of a collagen matrix . Positive_regulation MYL4 EPHB2 15665049 1402433 The present study tested the hypothesis that and PKC differentially *regulated* [myosin light chain] phosphatase activity by phosphorylation of myosin phosphatase target protein-1 ( MYPT-1 ) and CPI-17 . Positive_regulation MYL4 EPHB2 19179620 2049222 [Myosin light chain] activation by strain *required* FAK , Rac1 , PI3K , AKT , GSK , and but not Src or p38 . Positive_regulation MYL4 MAP2K6 17429073 1742450 In cultured endothelial cells , induction of [myosin light chain] phosphorylation by PAK is *mediated* by and extracellular signal regulated kinase ( Erk ) . Positive_regulation MYL4 SLC6A2 23184663 2723841 Importantly , we demonstrate that , but not Net1 , is *required* for cell spreading on collagen , [myosin light chain] phosphorylation , and focal adhesion maturation . Positive_regulation MYL4 SLC6A2 23792411 2824269 Importantly , plasma membrane localization of is *required* for efficient [myosin light chain] phosphorylation , focal adhesion maturation , and cell spreading . Positive_regulation MYL4 SNCAIP 10788802 689009 *induced* FAK tyrosine phosphorylation , [myosin light chain] phosphorylation , and the formation of stress fibers in HUVECs . Positive_regulation MYL4 SPHK1 17164439 1717006 Overexpressing human in these cells *resulted* in increased levels of the cell cycle regulator cyclin D1 and increased [myosin light-chain] phosphorylation . Positive_regulation MYL4 TNF 10574921 569206 Similar to gangliosides , [GT1b] *induced* production of NO and and expression of COX-2 . Positive_regulation MYL4 TNF 17476691 1772277 rapidly *induced* RhoA activation and [myosin light chain] phosphorylation , but caused only small changes to cortical F-actin , without significantly increasing paracellular permeability up to 30 min after stimulation . Positive_regulation MYL5 EPHB2 10477763 643329 signaling is independent of CAS/Crk coupling and *regulates* [myosin light chain] phosphorylation leading to actin-myosin assembly during cell migration and cell mediated contraction of a collagen matrix . Positive_regulation MYL5 EPHB2 15665049 1402434 The present study tested the hypothesis that and PKC differentially *regulated* [myosin light chain] phosphatase activity by phosphorylation of myosin phosphatase target protein-1 ( MYPT-1 ) and CPI-17 . Positive_regulation MYL5 EPHB2 19179620 2049226 [Myosin light chain] activation by strain *required* FAK , Rac1 , PI3K , AKT , GSK , and but not Src or p38 . Positive_regulation MYL5 MAP2K6 17429073 1742463 In cultured endothelial cells , induction of [myosin light chain] phosphorylation by PAK is *mediated* by and extracellular signal regulated kinase ( Erk ) . Positive_regulation MYL5 SLC6A2 23184663 2723842 Importantly , we demonstrate that Net1A , but not , is *required* for cell spreading on collagen , [myosin light chain] phosphorylation , and focal adhesion maturation . Positive_regulation MYL5 SLC6A2 23792411 2824270 Importantly , plasma membrane localization of is *required* for efficient [myosin light chain] phosphorylation , focal adhesion maturation , and cell spreading . Positive_regulation MYL5 SNCAIP 10788802 689010 *induced* FAK tyrosine phosphorylation , [myosin light chain] phosphorylation , and the formation of stress fibers in HUVECs . Positive_regulation MYL5 SPHK1 17164439 1717007 Overexpressing human in these cells *resulted* in increased levels of the cell cycle regulator cyclin D1 and increased [myosin light-chain] phosphorylation . Positive_regulation MYL5 TNF 17476691 1772278 rapidly *induced* RhoA activation and [myosin light chain] phosphorylation , but caused only small changes to cortical F-actin , without significantly increasing paracellular permeability up to 30 min after stimulation . Positive_regulation MYL6 EPHB2 10477763 643330 signaling is independent of CAS/Crk coupling and *regulates* [myosin light chain] phosphorylation leading to actin-myosin assembly during cell migration and cell mediated contraction of a collagen matrix . Positive_regulation MYL6 EPHB2 15665049 1402435 The present study tested the hypothesis that and PKC differentially *regulated* [myosin light chain] phosphatase activity by phosphorylation of myosin phosphatase target protein-1 ( MYPT-1 ) and CPI-17 . Positive_regulation MYL6 EPHB2 19179620 2049230 [Myosin light chain] activation by strain *required* FAK , Rac1 , PI3K , AKT , GSK , and but not Src or p38 . Positive_regulation MYL6 MAP2K6 17429073 1742476 In cultured endothelial cells , induction of [myosin light chain] phosphorylation by PAK is *mediated* by and extracellular signal regulated kinase ( Erk ) . Positive_regulation MYL6 SLC6A2 23184663 2723843 Importantly , we demonstrate that , but not Net1 , is *required* for cell spreading on collagen , [myosin light chain] phosphorylation , and focal adhesion maturation . Positive_regulation MYL6 SLC6A2 23792411 2824271 Importantly , plasma membrane localization of is *required* for efficient [myosin light chain] phosphorylation , focal adhesion maturation , and cell spreading . Positive_regulation MYL6 SNCAIP 10788802 689011 *induced* FAK tyrosine phosphorylation , [myosin light chain] phosphorylation , and the formation of stress fibers in HUVECs . Positive_regulation MYL6 SPHK1 17164439 1717008 Overexpressing human in these cells *resulted* in increased levels of the cell cycle regulator cyclin D1 and increased [myosin light-chain] phosphorylation . Positive_regulation MYL6 TNF 17476691 1772279 rapidly *induced* RhoA activation and [myosin light chain] phosphorylation , but caused only small changes to cortical F-actin , without significantly increasing paracellular permeability up to 30 min after stimulation . Positive_regulation MYL7 EPHB2 10477763 643323 signaling is independent of CAS/Crk coupling and *regulates* [myosin light chain] phosphorylation leading to actin-myosin assembly during cell migration and cell mediated contraction of a collagen matrix . Positive_regulation MYL7 EPHB2 15665049 1402428 The present study tested the hypothesis that and PKC differentially *regulated* [myosin light chain] phosphatase activity by phosphorylation of myosin phosphatase target protein-1 ( MYPT-1 ) and CPI-17 . Positive_regulation MYL7 EPHB2 19179620 2049193 [Myosin light chain] activation by strain *required* FAK , Rac1 , PI3K , AKT , GSK , and but not Src or p38 . Positive_regulation MYL7 MAP2K6 17429073 1742385 In cultured endothelial cells , induction of [myosin light chain] phosphorylation by PAK is *mediated* by and extracellular signal regulated kinase ( Erk ) . Positive_regulation MYL7 SLC6A2 23184663 2723836 Importantly , we demonstrate that Net1A , but not , is *required* for cell spreading on collagen , [myosin light chain] phosphorylation , and focal adhesion maturation . Positive_regulation MYL7 SLC6A2 23792411 2824264 Importantly , plasma membrane localization of is *required* for efficient [myosin light chain] phosphorylation , focal adhesion maturation , and cell spreading . Positive_regulation MYL7 SNCAIP 10788802 689004 *induced* FAK tyrosine phosphorylation , [myosin light chain] phosphorylation , and the formation of stress fibers in HUVECs . Positive_regulation MYL7 SPHK1 17164439 1717001 Overexpressing human in these cells *resulted* in increased levels of the cell cycle regulator cyclin D1 and increased [myosin light-chain] phosphorylation . Positive_regulation MYL7 TNF 17476691 1772271 rapidly *induced* RhoA activation and [myosin light chain] phosphorylation , but caused only small changes to cortical F-actin , without significantly increasing paracellular permeability up to 30 min after stimulation . Positive_regulation MYL9 EPHB2 10477763 643322 signaling is independent of CAS/Crk coupling and *regulates* [myosin light chain] phosphorylation leading to actin-myosin assembly during cell migration and cell mediated contraction of a collagen matrix . Positive_regulation MYL9 EPHB2 15665049 1402427 The present study tested the hypothesis that and PKC differentially *regulated* [myosin light chain] phosphatase activity by phosphorylation of myosin phosphatase target protein-1 ( MYPT-1 ) and CPI-17 . Positive_regulation MYL9 EPHB2 19179620 2049189 [Myosin light chain] activation by strain *required* FAK , Rac1 , PI3K , AKT , GSK , and but not Src or p38 . Positive_regulation MYL9 MAP2K6 17429073 1742372 In cultured endothelial cells , induction of [myosin light chain] phosphorylation by PAK is *mediated* by and extracellular signal regulated kinase ( Erk ) . Positive_regulation MYL9 SLC6A2 23184663 2723835 Importantly , we demonstrate that , but not Net1 , is *required* for cell spreading on collagen , [myosin light chain] phosphorylation , and focal adhesion maturation . Positive_regulation MYL9 SLC6A2 23792411 2824263 Importantly , plasma membrane localization of is *required* for efficient [myosin light chain] phosphorylation , focal adhesion maturation , and cell spreading . Positive_regulation MYL9 SNCAIP 10788802 689003 *induced* FAK tyrosine phosphorylation , [myosin light chain] phosphorylation , and the formation of stress fibers in HUVECs . Positive_regulation MYL9 SPHK1 17164439 1716999 Overexpressing human in these cells *resulted* in increased levels of the cell cycle regulator cyclin D1 and increased [myosin light-chain] phosphorylation . Positive_regulation MYL9 TNF 17476691 1772270 rapidly *induced* RhoA activation and [myosin light chain] phosphorylation , but caused only small changes to cortical F-actin , without significantly increasing paracellular permeability up to 30 min after stimulation . Positive_regulation MYLIP CTGF 22760500 2623143 A small molecule inhibitor of lysyl oxidase , BAPN , prevented the AngII as well as the *induced* [miR-21] expression . Positive_regulation MYLIP CTGF 23681229 2785462 Further , we discovered that attenuated *mediated* upregulation of [miR-18b] was dependent on the increased binding of transcription factors Jun proto-oncogene ( C-Jun ) and v-Myc myelocytomatosis viral oncogene homolog ( C-Myc ) to miR-18b promoter region via phosphoinositide 3-kinase (PI3K)/AKT pathway . Positive_regulation MYLIP CTGF 23681229 2785468 Our studies are the first to demonstrate that reduced as an unfavorable prognosis factor *mediates* the activation of [miR-18b] , an oncomir directly suppresses CTGF expression , by PI3K/AKT/C-Jun and C-Myc and promotes cell growth of NPC . Positive_regulation MYLIP EFNB1 20308325 2244639 Furthermore , we showed that [miR-124] is itself *regulated* by reverse signaling , thus revealing the existence of a mutually repressive interaction between ephrin-B1 and this microRNA ( miRNA ) . Positive_regulation MYLIP EPHB2 19438724 2090445 These results reveal that the signal *regulates* [miR-221/222] expression , and that these miRNAs might contribute to NGF dependent cell survival in PC12 cells . Positive_regulation MYLIP EPHB2 20299489 2260022 Cell signaling analysis showed that the activation of extracellular signal regulated protein kinase ( ) in response to PMA strongly *induced* [miR-34a] expression by transactivation via the activator protein-1 binding site in the upstream region of the miR-34a gene . Positive_regulation MYLIP EPHB2 23533157 2804074 Mechanistically , dependent *induction* of [miR-18a*] directly represses expression of DLL3 , an autocrine inhibitor of NOTCH , thus enhancing the level of activated NOTCH-1 . Positive_regulation MYLIP EPHB2 24253315 2898104 In addition , miR-29b is upregulated following ERK inhibition , suggesting a Snail dependent pathway by which Snail activation of TGF-ß and signaling *results* in downregulation of [miR-29b] and subsequent upregulation of SPARC . Positive_regulation MYLIP FAS 23929433 2887885 Inhibition of signaling by downregulation of the Fas receptor *led* to a decrease in [miR-23a] expression and cell invasion ability in vivo and in vitro , as well as an increase in E-cadherin . Positive_regulation MYLIP ID1 22249264 2668239 Saracatinib and dasatinib decreased c-Myc transcriptional repression on miR-29b and led to increased ID1 protein levels , whereas forced expression of c-Myc repressed [miR-29b] and *induced* . Positive_regulation MYLIP IL1B 18383392 1899214 Constitutive expression of both miR-155 and miR-146a was higher in RASFs than in those from patients with osteoarthritis ( OA ) , and expression of [miR-155] could be further *induced* by TNFalpha , , lipopolysaccharide , poly ( I-C ) , and bacterial lipoprotein . Positive_regulation MYLIP IL1B 18438844 1915448 This study shows that [miR-146] is expressed in RA synovial tissue and that its expression is *induced* by stimulation with TNFalpha and . Positive_regulation MYLIP IL1B 19333945 2056486 This study shows that [miR-146] is intensely expressed in low-grade OA cartilage and that its expression is *induced* by stimulation of . Positive_regulation MYLIP IL1B 19714579 2139315 The reduction in [miR-140] expression in OA cartilage and in *response* to may contribute to the abnormal gene expression pattern characteristic of OA . Positive_regulation MYLIP IL1B 19786024 2153707 Divergent intracellular pathways regulate *induced* [miR-146a] and miR-146b expression and chemokine release in human alveolar epithelial cells . Positive_regulation MYLIP IL1B 19786024 2153710 Subsequent pharmacological studies show that *induced* [miR-146a] , IL-8 and RANTES production was regulated via NF-kappaB and JNK-1/2 whilst miR-146b expression was mediated via MEK-1/2 and JNK-1/2 . Positive_regulation MYLIP IL1B 20086228 2226051 We found that and TNF-alpha *induce* the expression of miR-21 , miR-34a , and [miR-146a] both in MIN6 cells and human pancreatic islets . Positive_regulation MYLIP IL1B 20525168 2284201 Functional studies indicated that *induced* [miR-146a] expression does not negatively regulate IL-6 and IL-8 release or basal proliferation . Positive_regulation MYLIP IL1B 20525168 2284212 We have shown that *induced* [miR-146a] expression in HASM and that this was regulated at the transcriptional level by NF-kappaB and at the post-transcriptional level by the MEK-1/2 and JNK-1/2 . Positive_regulation MYLIP JAG1 21685392 2465408 Activation of Notch receptors by *caused* CBF1 dependent up-regulation of [miR-143/145] , increased differentiation , and decreased proliferation . Positive_regulation MYLIP JAG1 21685392 2465422 Using SRF knockdown , we found that *induction* of [miR-143/145] is SRF independent , although full acquisition of contractile markers requires SRF . Positive_regulation MYLIP JAG1 21685392 2465428 Using miR-143/145 interfering oligonucleotides , we demonstrate that signaling *requires* induction of both [miR-143] and miR-145 to promote the VSMC contractile phenotype . Positive_regulation MYLIP MAP2K6 24631982 2930365 Reciprocally , [miR-21] levels were *induced* by or JNK signaling response to T cell receptor ( TCR ) engagement . Positive_regulation MYLIP MYH16 22666483 2611128 In rodent heart , and its micro-RNA miR-208a *regulate* the expression of beta-MyHC and of its intronic [miR-208b] . Positive_regulation MYLIP MYH3 22666483 2611135 In rodent heart , and its micro-RNA miR-208a *regulate* the expression of beta-MyHC and of its intronic [miR-208b] . Positive_regulation MYLIP NR2F1 24349493 2881282 Based on this , we performed chromatin-immunoprecipitation followed by qRT-PCR and confirmed that directly binds and *regulates* both [miR-140] and Klf9 in vivo . Positive_regulation MYLIP PGC 23111009 2740601 Finally , enforced expression of *increased* [miR-29a-c] expression levels in primary hepatocytes , thus forming a negative feedback regulation loop . Positive_regulation MYLIP TLR7 19721002 2145429 These data demonstrate a negative-feedback loop in which stimulation *induces* [miR-147] to prevent excessive inflammatory responses . Positive_regulation MYLIP TLR7 21068409 2354713 We also found that expression of [miR-101] is *induced* by multiple ligands , including LPS , peptidoglycan , or polyinosinic-polycytidylic acid , and that inhibition of PI3K/Akt by LY294002 or Akt RNA interference blocks the induction of miR-101 by LPS in RAW264.7 macrophage cells . Positive_regulation MYLIP TLR7 22170100 2517994 Astrocyte [miR-155/miR155*] were *induced* by cytokines and ligands with a distinct hierarchy and involved in proinflammatory cytokine gene induction by targeting suppressor of cytokine signaling 1 , a negative regulator of cytokine signaling and potentially other factors . Positive_regulation MYLIP TNF 17911593 1803693 Modulation of [miR-155] and miR-125b levels *following* stimulation and their possible roles in regulating the response to endotoxin shock . Positive_regulation MYLIP TNF 17911593 1803694 Altogether , our data suggest that the *dependent* regulation of [miR-155] and miR-125b may be implicated in the response to endotoxin shock , thus offering new targets for drug design . Positive_regulation MYLIP TNF 18383392 1899213 Constitutive expression of both miR-155 and miR-146a was higher in RASFs than in those from patients with osteoarthritis ( OA ) , and expression of [miR-155] could be further *induced* by , interleukin-1beta , lipopolysaccharide , poly ( I-C ) , and bacterial lipoprotein . Positive_regulation MYLIP TNF 18438844 1915447 This study shows that [miR-146] is expressed in RA synovial tissue and that its expression is *induced* by stimulation with and IL-1beta . Positive_regulation MYLIP TNF 19949084 2190699 Specifically , E-selectin and ICAM-1 are targets of *induced* miRNAs [miR-31] and miR-17-3p , respectively . Positive_regulation MYLIP TNF 20086228 2226050 We found that IL-1beta and *induce* the expression of [miR-21] , miR-34a , and miR-146a both in MIN6 cells and human pancreatic islets . Positive_regulation MYLIP TNF 20948191 2343641 IFN-? and synergistically *induced* the expression of [miR-155] . Positive_regulation MYLIP TNF 20948191 2343642 Combined stimulation with IFN-? and *induces* [miR-155] via TAB2 and NF-?B . Positive_regulation MYLIP TNF 21763238 2484437 Transfection of enterocytes with an antisense oligoribonucleotide against miR-122a blocked the *induced* increase in enterocyte expression of [miR-122a] , degradation of occludin mRNA , and increase in intestinal permeability . Positive_regulation MYLIP TNF 21947847 2562385 We found that IL-8 , , and IL-1ß could *contribute* to the induction of [miR-146a] in gastric epithelial cell HGC-27 in NF-?B dependent manner , while the induction of miR-146a upon H. pylori stimulation was independent of above proinflammatory cytokines . Positive_regulation MYLIP TNF 22634176 2638261 Furthermore , [miR-155] expression could be *induced* by through the JNK pathway . Positive_regulation MYLIP TNF 22773691 2659882 Basal and *induced* expression of [miR-140-3p] was determined in nonasthmatic ASM ( NAASM ) and asthmatic ASM ( AASM ) cells . Positive_regulation MYLIP TNF 23108656 2699216 Moreover , we observed that simvastatin attenuated *induced* upregulation of [miR-155] and ameliorated the effects of tumor necrosis factor-a on eNOS expression and endothelium dependent vasodilation . Positive_regulation MYLIP TNF 23338610 2775687 Also , we report for the first time that HER2/neu ( ERBB2 ) , EGF , and *promote* [miR-23b/27b] expression through the AKT/NF-?B signaling cascade . Positive_regulation MYLIP TNF 23592910 2773334 Our results clearly show that both [miR-146a] and miR-146b-5p are expressed in human RPE cells in culture and their expression is highly *induced* by proinflammatory cytokines ( IFN-? + + IL-1ß ) . Positive_regulation MYLIP TNF 23636891 2848766 Modulation of expression , either by stimulation using myeloid related protein ( MRP8 ) or lipopolysaccharide or inhibition using lenalidomide on astrocytes , *leads* to similar dynamic changes in [miR-155] expression . Positive_regulation MYLIP TNF 24065523 2857717 FFAs , resistin , and leptin downregulated miR-143 expression in human adipocytes , whereas and IL-6 *had* little effect on [miR-143] expression . Positive_regulation MYLIP TNFSF10 21706050 2538787 [miR-130a] targets MET and *induces* in NSCLC by downregulating miR-221 and 222 . Positive_regulation MYLIP TNFSF10 23647548 2805292 *induced* [miR-146a] expression suppresses CXCR4 mediated human breast cancer migration . Positive_regulation MYLIP TNFSF10 23647548 2805293 A neutralization antibody against DR4 specifically blocked *induced* NF-?B activation and [miR-146a] expression . Positive_regulation MYLIP TNFSF10 23647548 2805295 These results were confirmed in a human breast cancer xenograft mouse model , suggesting that TRAIL significantly enhanced miR-146a expression and suppressed CXCR4 expression , indicating that *induced* [miR-146a] up-regulation is negatively associated with CXCR4 expression . Positive_regulation MYLIP TNFSF10 23647548 2805296 These findings suggest that *induced* [miR-146a] expression suppresses CXCR4 mediated human breast cancer migration , and provide further insight into the non-apoptotic function of TRAIL in the prevention of metastasis as a therapy for breast cancer . Positive_regulation MYLIP TP63 22949650 2672655 Here , we show that ( both TAp63 and ?Np63 isoforms ) *regulates* expression of [miR-205] in prostate cancer ( PCa ) cells , and miR-205 is essential for the inhibitory effects of p63 on markers of epithelial-mesenchymal transition (EMT) , such as ZEB1 and vimentin . Positive_regulation MYLIP WIF1 24853424 2940633 Furthermore , significantly *increased* the expression of microRNAs pri-let-7a and [pri-miR-200c] , negative regulators of stemness and cancer progression . Positive_regulation MYLK CAPN8 2829910 82669 Collectively , the data indicated that may *activate* both [MLCK] and C-kinase to phosphorylate 20K by partial proteolysis . Positive_regulation MYLK CAPN8 2847354 100310 Thus , it was suggested that *enhances* [MLCK] activity on 20K phosphorylation in intact platelets following the stimulation by the agonist which elevates [ Ca2+ ] i . Positive_regulation MYLK EPHB2 19896381 2166010 To enable microvesicle shedding , ARF6-GTP dependent activation of phospholipase D promotes the recruitment of the extracellular signal regulated kinase ( ERK ) to the plasma membrane where , in turn , phosphorylates and *activates* [myosin light-chain kinase (MLCK)] . Positive_regulation MYLK EPHB2 24116218 2853119 Collectively , our results are the first to delineate a *role* for calcium and in the activation of [MLCK] and thus MyoIIA during insulin stimulated glucose uptake in 3T3-L1 adipocytes . Positive_regulation MYLK IL1B 18390750 1893369 *caused* a progressive increase in [MLCK] protein expression . Positive_regulation MYLK IL1B 18390750 1893370 The time course of *induced* increase in [MLCK] level correlated linearly with increase in Caco-2 TJ permeability . Positive_regulation MYLK IL1B 18390750 1893371 The *induced* increase in [MLCK] protein expression was preceded by an increase in MLCK mRNA expression . Positive_regulation MYLK IL1B 18390750 1893372 The *induced* increase in MLCK mRNA transcription and subsequent increase in [MLCK] protein expression and Caco-2 TJ permeability was mediated by activation of NF-kappaB . Positive_regulation MYLK IL1B 18390750 1893376 Our findings also indicate that the *induced* increase in [MLCK] protein expression and Caco-2 TJ permeability was mediated by an NF-kappaB dependent increase in MLCK gene transcription . Positive_regulation MYLK MAP2K6 10733514 678427 These results are consistent with the interpretation that *activates* ERK , ERK2 then activates [MLCK] , and MLCK activates myosin . Positive_regulation MYLK TNF 12631580 1067744 *induced* the caspase dependent cleavage of EC [MLCK-1745] in transfected endothelial cells , which was confirmed by mass spectroscopy with in vitro cleavage by caspase 3 at LKKD ( D1703 ) . Positive_regulation MYLK TNF 15526279 1360011 We previously demonstrated that increased EC contractility , rearrangement of the actin cytoskeleton , and increased myosin light chain (MLC) phosphorylation occurs as a consequence of *induced* activation of EC MLC kinase ( EC [MLCK] ) and is required for bovine lung EC apoptosis . Positive_regulation MYLK TNF 15681825 1366523 However , at doses below those needed for nuclear factor-kappaB inhibition , sulfasalazine was able to prevent *induced* barrier dysfunction , [MLCK] up-regulation , and MLC phosphorylation . Positive_regulation MYLK TNF 15701621 1372565 ( 10 ng/ml ) produced a time dependent *increase* in Caco-2 [MLCK] expression . Positive_regulation MYLK TNF 15701621 1372566 The TNF-alpha increase in MLCK protein expression paralleled the increase in Caco-2 TJ permeability , and the inhibition of the *induced* [MLCK] expression ( by cycloheximide ) prevented the increase in Caco-2 TJ permeability , suggesting that MLCK expression may be required for the increase in Caco-2 TJ permeability . Positive_regulation MYLK TNF 16474009 1524006 The *induced* increase in [MLCK] transcription corresponded to a sequential increase in MLCK protein expression , MLCK activity , and Caco-2 TJ permeability . Positive_regulation MYLK TNF 16474009 1524009 The *induced* increase in [MLCK] promoter activity was mediated by NF-kappaB activation , and the inhibition of NF-kappaB activation prevented the TNF-alpha induced increase in promoter activity and the subsequent increase in MLCK protein expression and Caco-2 TJ permeability . Positive_regulation MYLK TNF 16474009 1524012 The *induced* activation of [MLCK] promoter was mediated by binding of the activated NF-kappaB p50/p65 dimer to the downstream kappaB binding site ( -84 to -75 ) on the MLCK promoter region ; Positive_regulation MYLK TNF 16835238 1606489 We found that *increases* long [MLCK] mRNA transcription , both in human enterocytes in vitro and murine enterocytes in vivo.5'-RACE identified two novel exons , 1A and 1B , which encode alternative long MLCK transcriptional start sites . Positive_regulation MYLK TNF 16835238 1606491 Analysis of differentiating epithelia showed that only well differentiated enterocytes activated the 4-kb long [MLCK] promoter in *response* to , and consensus promoter reporters demonstrated that TNF induced NFkappaB activation decreased during differentiation while TNF induced AP-1 activation increased . Positive_regulation MYLK TNF 17068119 1693031 Glucocorticoids inhibited the *induced* increase in [myosin light chain kinase (MLCK)] protein expression , a key process mediating the TNF-alpha increase in intestinal TJ permeability . Positive_regulation MYLK TNF 17068119 1693032 The prednisolone protective action was mediated by binding of activated GR complex to the GRE site on the MLCK promoter , suppressing the *induced* increase in [MLCK] gene activity , protein expression , and subsequent opening of the intestinal TJ barrier . Positive_regulation MYLK TNF 18363837 1957968 The major aim of this study was to elucidate the cellular and molecular mechanisms that mediate basal and *induced* increase in [MLCK] gene activity . Positive_regulation MYLK TNF 18363837 1957971 In conclusion , we have identified the minimal MLCK promoter region , essential molecular determinants and molecular mechanisms that mediate basal and *induced* modulation of [MLCK] promoter activity in Caco-2 intestinal epithelial cells . Positive_regulation MYLK TNF 18363837 1957972 These studies provide novel insight into the cellular and molecular mechanisms that regulate basal and *induced* modulation of [MLCK] gene activity . Positive_regulation MYLK TNF 19131801 2025329 Prior studies have shown that *activates* [MLCK] , in part through a nuclear factor (NF)-kappa B-dependent pathway . Positive_regulation MYLK TNF 22731710 2616800 ( TNF-a ) *causes* a [myosin light chain kinase (MLCK)] -- mediated barrier regulation by inducing occludin removal from the tight junction through caveolar endocytosis . Positive_regulation MYLK TNF 23492194 2803913 We identified increased [MYLK] gene transcription *induced* by ( 24 h ; 4.7 ± 0.45 fold increase [ FI ] ) , LPS ( 4 h ; 2.85 ± 0.15 [ FI ] ) , and 18 % cyclic stretch ( 24 h ; 4.6 ± 0.24 FI ) that was attenuated by transfection of human lung ECs with mimics of hsa-miR-374a , hsa-miR-374b , hsa-miR-520c-3p , or hsa-miR-1290 ( 20-80 % reductions by each miRNA ) . Positive_regulation MYLK TNF 23671580 2785125 The increase of both MLC phosphorylation and [MLCK] protein expression *induced* by IFN-? and was significantly inhibited by berberine treatment . Positive_regulation MYO10 EDN2 8638958 362478 Comparison of the time courses of myosin phosphorylation at optimal ( Lo ) and preshortened lengths indicated that the initial peak [myosin] phosphorylation *induced* by K ( + ) -depolarization , histamine , and were all length dependent . Positive_regulation MYO10 EDN2 8638958 362490 In contrast , the length dependence of *induced* steady-state [myosin] phosphorylation ( 0.03 mol P ( i ) /mol LC/Lo ) was insignificant . Positive_regulation MYO10 EDN2 8638958 362502 The different length dependences of depolarization- and *induced* [myosin] phosphorylation were found to correlate with different length-force relations . Positive_regulation MYO10 EPHB2 17429073 1742506 We conclude that the PAK-PIX-GIT1 complex is critical for *dependent* [myosin] phosphorylation and vascular permeability . Positive_regulation MYO10 F2R 22326025 2565499 We further demonstrate that the cell polarity protein ( MARK ) , a serine-threonine kinase , *regulates* the localization and activation of [Myo-II] in border cells . Positive_regulation MYO10 F2R 22326025 2565507 Furthermore , localizes to and *increases* active [Myo-II] at the cluster rear to promote detachment ; Positive_regulation MYO10 ITGB2 11254681 794088 Stromal cell derived factor-1 induced activation during in vivo migration of T cell hybridoma cells *requires* Gq/11 , RhoA , and [myosin] , as well as Gi and Cdc42 . Positive_regulation MYO10 MAP2K6 10733514 678434 These results are consistent with the interpretation that activates ERK , ERK2 then activates MLCK , and MLCK *activates* [myosin] . Positive_regulation MYO10 MAP2K6 15075377 1251841 Inhibitors of , ROCK , or MLCK also *suppress* peripheral accumulation of [phospho-myosin] and Src induced formation of integrin dependent adhesions , whereas at the same time restoring E-cadherin redistribution to regions of cell-cell contact . Positive_regulation MYO10 MYH16 9398679 469089 This suggests that [myosin] localization in dividing cells is *regulated* by phosphorylation . Positive_regulation MYO10 MYH3 9398679 469096 This suggests that [myosin] localization in dividing cells is *regulated* by phosphorylation . Positive_regulation MYO10 OXTR 14556093 1153221 Binding of OT to its corresponding receptor , , *leads* to activation of [actin-myosin] interactions and therewith myometrial contractions as well as production of intrauterine prostaglandins ( PGE ( 2 ) , PGF ( 2 alpha ) ) mainly in decidua and myometrium . Positive_regulation MYO10 TMOD1 14507711 1145099 *Activation* of the calcium regulated by [myosin] strong binding . Positive_regulation MYO10 TMOD1 18165684 1875400 We conclude that the highly conserved Asp-137 destabilizes the middle of Tm , resulting in a more flexible region that is important for the cooperative *activation* of the by [myosin] . Positive_regulation MYO10 TMOD1 19799913 2195772 In conclusion , E99K inhibits the *activation* of the by [myosin] strong binding whereas R312H demonstrates enhanced calcium activation . Positive_regulation MYO10 TMOD1 7787029 310019 The steeper slope in cardiac myocytes provides evidence of greater [myosin] binding induced cooperative *activation* of the in cardiac as compared with skeletal muscle , at least under these experimental conditions of nominal free Ca2+ . Positive_regulation MYO10 TNF 11350795 814706 Exploring the involvement of the actomyosin cytoskeleton in these important endothelial cell responses , we determined that significantly *increased* [myosin light chain (MLC)] phosphorylation , with prominent stress fiber and paracellular gap formation , which paralleled the onset of decreases in transcellular electrical resistance and enhanced apoptosis . Positive_regulation MYO10 TNF 15526279 1360012 We previously demonstrated that increased EC contractility , rearrangement of the actin cytoskeleton , and increased [myosin light chain (MLC)] phosphorylation occurs as a *consequence* of induced activation of EC MLC kinase ( EC MLCK ) and is required for bovine lung EC apoptosis . Positive_regulation MYO10 TNF 23861542 2817160 In resting endothelial cells , [myosin] was bound constitutively to the intracellular region of p75 , a region that overlaps with the TRAF2 binding domain , and *caused* the rapid dissociation of myosin from p75 . Positive_regulation MYO16 EDN2 8638958 362475 Comparison of the time courses of myosin phosphorylation at optimal ( Lo ) and preshortened lengths indicated that the initial peak [myosin] phosphorylation *induced* by K ( + ) -depolarization , histamine , and were all length dependent . Positive_regulation MYO16 EDN2 8638958 362487 In contrast , the length dependence of *induced* steady-state [myosin] phosphorylation ( 0.03 mol P ( i ) /mol LC/Lo ) was insignificant . Positive_regulation MYO16 EDN2 8638958 362499 The different length dependences of depolarization- and *induced* [myosin] phosphorylation were found to correlate with different length-force relations . Positive_regulation MYO16 EPHB2 17429073 1742498 We conclude that the PAK-PIX-GIT1 complex is critical for *dependent* [myosin] phosphorylation and vascular permeability . Positive_regulation MYO16 F2R 22326025 2565498 We further demonstrate that the cell polarity protein ( MARK ) , a serine-threonine kinase , *regulates* the localization and activation of [Myo-II] in border cells . Positive_regulation MYO16 F2R 22326025 2565506 Furthermore , localizes to and *increases* active [Myo-II] at the cluster rear to promote detachment ; Positive_regulation MYO16 ITGB2 11254681 794077 Stromal cell derived factor-1 induced activation during in vivo migration of T cell hybridoma cells *requires* Gq/11 , RhoA , and [myosin] , as well as Gi and Cdc42 . Positive_regulation MYO16 MAP2K6 10733514 678404 These results are consistent with the interpretation that activates ERK , ERK2 then activates MLCK , and MLCK *activates* [myosin] . Positive_regulation MYO16 MAP2K6 15075377 1251831 Inhibitors of , ROCK , or MLCK also *suppress* peripheral accumulation of [phospho-myosin] and Src induced formation of integrin dependent adhesions , whereas at the same time restoring E-cadherin redistribution to regions of cell-cell contact . Positive_regulation MYO16 MYH16 9398679 469075 This suggests that [myosin] localization in dividing cells is *regulated* by phosphorylation . Positive_regulation MYO16 MYH3 9398679 469082 This suggests that [myosin] localization in dividing cells is *regulated* by phosphorylation . Positive_regulation MYO16 OXTR 14556093 1153220 Binding of OT to its corresponding receptor , , *leads* to activation of [actin-myosin] interactions and therewith myometrial contractions as well as production of intrauterine prostaglandins ( PGE ( 2 ) , PGF ( 2 alpha ) ) mainly in decidua and myometrium . Positive_regulation MYO16 TMOD1 14507711 1145096 *Activation* of the calcium regulated by [myosin] strong binding . Positive_regulation MYO16 TMOD1 18165684 1875397 We conclude that the highly conserved Asp-137 destabilizes the middle of Tm , resulting in a more flexible region that is important for the cooperative *activation* of the by [myosin] . Positive_regulation MYO16 TMOD1 19799913 2195769 In conclusion , E99K inhibits the *activation* of the by [myosin] strong binding whereas R312H demonstrates enhanced calcium activation . Positive_regulation MYO16 TMOD1 7787029 310016 The steeper slope in cardiac myocytes provides evidence of greater [myosin] binding induced cooperative *activation* of the in cardiac as compared with skeletal muscle , at least under these experimental conditions of nominal free Ca2+ . Positive_regulation MYO16 TNF 11350795 814705 Exploring the involvement of the actomyosin cytoskeleton in these important endothelial cell responses , we determined that significantly *increased* [myosin light chain (MLC)] phosphorylation , with prominent stress fiber and paracellular gap formation , which paralleled the onset of decreases in transcellular electrical resistance and enhanced apoptosis . Positive_regulation MYO16 TNF 15526279 1360009 We previously demonstrated that increased EC contractility , rearrangement of the actin cytoskeleton , and increased [myosin light chain (MLC)] phosphorylation occurs as a *consequence* of induced activation of EC MLC kinase ( EC MLCK ) and is required for bovine lung EC apoptosis . Positive_regulation MYO16 TNF 23861542 2817159 In resting endothelial cells , [myosin] was bound constitutively to the intracellular region of p75 , a region that overlaps with the TRAF2 binding domain , and *caused* the rapid dissociation of myosin from p75 . Positive_regulation MYO19 EDN2 8638958 362472 Comparison of the time courses of myosin phosphorylation at optimal ( Lo ) and preshortened lengths indicated that the initial peak [myosin] phosphorylation *induced* by K ( + ) -depolarization , histamine , and were all length dependent . Positive_regulation MYO19 EDN2 8638958 362484 In contrast , the length dependence of *induced* steady-state [myosin] phosphorylation ( 0.03 mol P ( i ) /mol LC/Lo ) was insignificant . Positive_regulation MYO19 EDN2 8638958 362496 The different length dependences of depolarization- and *induced* [myosin] phosphorylation were found to correlate with different length-force relations . Positive_regulation MYO19 EPHB2 17429073 1742490 We conclude that the PAK-PIX-GIT1 complex is critical for *dependent* [myosin] phosphorylation and vascular permeability . Positive_regulation MYO19 F2R 22326025 2565497 We further demonstrate that the cell polarity protein ( MARK ) , a serine-threonine kinase , *regulates* the localization and activation of [Myo-II] in border cells . Positive_regulation MYO19 F2R 22326025 2565505 Furthermore , localizes to and *increases* active [Myo-II] at the cluster rear to promote detachment ; Positive_regulation MYO19 ITGB2 11254681 794075 Stromal cell derived factor-1 induced activation during in vivo migration of T cell hybridoma cells *requires* Gq/11 , RhoA , and [myosin] , as well as Gi and Cdc42 . Positive_regulation MYO19 MAP2K6 10733514 678396 These results are consistent with the interpretation that activates ERK , ERK2 then activates MLCK , and MLCK *activates* [myosin] . Positive_regulation MYO19 MAP2K6 15075377 1251821 Inhibitors of , ROCK , or MLCK also *suppress* peripheral accumulation of [phospho-myosin] and Src induced formation of integrin dependent adhesions , whereas at the same time restoring E-cadherin redistribution to regions of cell-cell contact . Positive_regulation MYO19 MYH16 9398679 469061 This suggests that [myosin] localization in dividing cells is *regulated* by phosphorylation . Positive_regulation MYO19 MYH3 9398679 469068 This suggests that [myosin] localization in dividing cells is *regulated* by phosphorylation . Positive_regulation MYO19 OXTR 14556093 1153219 Binding of OT to its corresponding receptor , , *leads* to activation of [actin-myosin] interactions and therewith myometrial contractions as well as production of intrauterine prostaglandins ( PGE ( 2 ) , PGF ( 2 alpha ) ) mainly in decidua and myometrium . Positive_regulation MYO19 TMOD1 14507711 1145089 *Activation* of the calcium regulated by [myosin] strong binding . Positive_regulation MYO19 TMOD1 18165684 1875390 We conclude that the highly conserved Asp-137 destabilizes the middle of Tm , resulting in a more flexible region that is important for the cooperative *activation* of the by [myosin] . Positive_regulation MYO19 TMOD1 19799913 2195762 In conclusion , E99K inhibits the *activation* of the by [myosin] strong binding whereas R312H demonstrates enhanced calcium activation . Positive_regulation MYO19 TMOD1 7787029 310009 The steeper slope in cardiac myocytes provides evidence of greater [myosin] binding induced cooperative *activation* of the in cardiac as compared with skeletal muscle , at least under these experimental conditions of nominal free Ca2+ . Positive_regulation MYO19 TNF 11350795 814704 Exploring the involvement of the actomyosin cytoskeleton in these important endothelial cell responses , we determined that significantly *increased* [myosin light chain (MLC)] phosphorylation , with prominent stress fiber and paracellular gap formation , which paralleled the onset of decreases in transcellular electrical resistance and enhanced apoptosis . Positive_regulation MYO19 TNF 15526279 1360007 We previously demonstrated that increased EC contractility , rearrangement of the actin cytoskeleton , and increased [myosin light chain (MLC)] phosphorylation occurs as a *consequence* of induced activation of EC MLC kinase ( EC MLCK ) and is required for bovine lung EC apoptosis . Positive_regulation MYO19 TNF 23861542 2817158 In resting endothelial cells , [myosin] was bound constitutively to the intracellular region of p75 , a region that overlaps with the TRAF2 binding domain , and *caused* the rapid dissociation of myosin from p75 . Positive_regulation MYO1F MYH16 16443752 1516976 [Myosin-IE] motor activity is *regulated* by phosphorylation , which increases the coupling efficiency between the actin and nucleotide binding sites tenfold and the motile activity more than fivefold . Positive_regulation MYO1F MYH3 16443752 1516983 [Myosin-IE] motor activity is *regulated* by phosphorylation , which increases the coupling efficiency between the actin and nucleotide binding sites tenfold and the motile activity more than fivefold . Positive_regulation MYO6 EDN2 8638958 362481 Comparison of the time courses of myosin phosphorylation at optimal ( Lo ) and preshortened lengths indicated that the initial peak [myosin] phosphorylation *induced* by K ( + ) -depolarization , histamine , and were all length dependent . Positive_regulation MYO6 EDN2 8638958 362493 In contrast , the length dependence of *induced* steady-state [myosin] phosphorylation ( 0.03 mol P ( i ) /mol LC/Lo ) was insignificant . Positive_regulation MYO6 EDN2 8638958 362505 The different length dependences of depolarization- and *induced* [myosin] phosphorylation were found to correlate with different length-force relations . Positive_regulation MYO6 EPHB2 17429073 1742514 We conclude that the PAK-PIX-GIT1 complex is critical for *dependent* [myosin] phosphorylation and vascular permeability . Positive_regulation MYO6 F2R 22326025 2565500 We further demonstrate that the cell polarity protein ( MARK ) , a serine-threonine kinase , *regulates* the localization and activation of [Myo-II] in border cells . Positive_regulation MYO6 F2R 22326025 2565508 Furthermore , localizes to and *increases* active [Myo-II] at the cluster rear to promote detachment ; Positive_regulation MYO6 ITGB2 11254681 794090 Stromal cell derived factor-1 induced activation during in vivo migration of T cell hybridoma cells *requires* Gq/11 , RhoA , and [myosin] , as well as Gi and Cdc42 . Positive_regulation MYO6 MAP2K6 10733514 678442 These results are consistent with the interpretation that activates ERK , ERK2 then activates MLCK , and MLCK *activates* [myosin] . Positive_regulation MYO6 MAP2K6 15075377 1251851 Inhibitors of , ROCK , or MLCK also *suppress* peripheral accumulation of [phospho-myosin] and Src induced formation of integrin dependent adhesions , whereas at the same time restoring E-cadherin redistribution to regions of cell-cell contact . Positive_regulation MYO6 MYH16 9398679 469103 This suggests that [myosin] localization in dividing cells is *regulated* by phosphorylation . Positive_regulation MYO6 MYH3 9398679 469110 This suggests that [myosin] localization in dividing cells is *regulated* by phosphorylation . Positive_regulation MYO6 OXTR 14556093 1153222 Binding of OT to its corresponding receptor , , *leads* to activation of [actin-myosin] interactions and therewith myometrial contractions as well as production of intrauterine prostaglandins ( PGE ( 2 ) , PGF ( 2 alpha ) ) mainly in decidua and myometrium . Positive_regulation MYO6 TMOD1 14507711 1145102 *Activation* of the calcium regulated by [myosin] strong binding . Positive_regulation MYO6 TMOD1 18165684 1875403 We conclude that the highly conserved Asp-137 destabilizes the middle of Tm , resulting in a more flexible region that is important for the cooperative *activation* of the by [myosin] . Positive_regulation MYO6 TMOD1 19799913 2195775 In conclusion , E99K inhibits the *activation* of the by [myosin] strong binding whereas R312H demonstrates enhanced calcium activation . Positive_regulation MYO6 TMOD1 7787029 310022 The steeper slope in cardiac myocytes provides evidence of greater [myosin] binding induced cooperative *activation* of the in cardiac as compared with skeletal muscle , at least under these experimental conditions of nominal free Ca2+ . Positive_regulation MYO6 TNF 11350795 814707 Exploring the involvement of the actomyosin cytoskeleton in these important endothelial cell responses , we determined that significantly *increased* [myosin light chain (MLC)] phosphorylation , with prominent stress fiber and paracellular gap formation , which paralleled the onset of decreases in transcellular electrical resistance and enhanced apoptosis . Positive_regulation MYO6 TNF 15526279 1360014 We previously demonstrated that increased EC contractility , rearrangement of the actin cytoskeleton , and increased [myosin light chain (MLC)] phosphorylation occurs as a *consequence* of induced activation of EC MLC kinase ( EC MLCK ) and is required for bovine lung EC apoptosis . Positive_regulation MYO6 TNF 23861542 2817161 In resting endothelial cells , [myosin] was bound constitutively to the intracellular region of p75 , a region that overlaps with the TRAF2 binding domain , and *caused* the rapid dissociation of myosin from p75 . Positive_regulation MYOCD EPHB2 19432968 2084104 Thrombin induces Egr-1 expression in fibroblasts involving elevation of the intracellular Ca2+ concentration , phosphorylation of and *activation* of [ternary complex] factor . Positive_regulation MYOCD EPHB2 20446923 2275061 [Myocardin] expression was *stimulated* by AngII and ( extracellular-signal regulated kinase ) phosphorylation , but was suppressed by an ARB ( AngII type 1 receptor blocker ) , an ERK pathway inhibitor and myocardin siRNA ( small interfering RNA ) . Positive_regulation MYOCD EPHB2 22129233 2579600 [Myocardin] expression after hypoxia was *inhibited* by atorvastatin , RhoA/Rho kinase inhibitor ( Y27632 ) , extracellular signal regulated kinase ( ERK ) small interfering RNA ( siRNA ) pathway inhibitor ( PD98059 ) , myocardin siRNA and NAC . Positive_regulation MYOCD NRARP 11485984 845014 We show that Nrarp forms a [ternary complex] with the ICD of XNotch1 and the CSL protein XSu ( H ) and that in embryos *promotes* the loss of ICD . Positive_regulation MYOCD TNF 24855642 2951107 We tested whether high insulin affects activation of *induced* NF-?B and [myocardin/serum] response factor (SRF) to convey hypertrophy signaling in cardiac myoblasts . Positive_regulation MYOCD TNNT2 24744906 2936387 [Myocardin] *induced* the expression of a-MHC , GATA4 , a-actinin , cardiac MHC , MYH11 , calponin , and SM a-actin , but not , ß-MHC , and MLC2v in iPSC-MSCs . Positive_regulation MYOD1 FOXO1 23645752 2779585 Pulse-chase and cycloheximide experiments suggest that GREM1 , DAPK1 , and [MYOD1] are directly *regulated* by . Positive_regulation MYOD1 MSX1 1360150 204526 Here we report that forced expression of .1 blocks terminal differentiation and *results* in a corresponding decrease in steady-state levels of [MyoD1] . Positive_regulation MYOG FBXO32 23526547 2799728 As expected , over-expression of *stimulated* the expression of troponin T and [myogenin] and differentiation of the L6 myoblasts . Positive_regulation MYOG FBXO32 23526547 2799729 Co-expression of myocardin with atrogin-1 inhibited *induced* [myogenin] expression . Positive_regulation MYOG FOXO1 17922034 1882423 We show that while *activates* the expression of endogenous MyoD and [myogenin] proteins in transduced NIH3T3 fibroblasts , it inhibits them from terminally differentiating as shown by low myogenin and myosin heavy chain expression , and lack of myotube formation . Positive_regulation MYOG ID1 15322112 1323169 Forced expression of , either by transient transfection or under the control of an inducible system , *causes* degradation of [myogenin] in the absence of BMP-2 . Positive_regulation MYOG ID1 15322112 1323172 Our findings indicate that induction of not only blocks transcriptional activity but also *induces* [myogenin] degradation by blocking formation of myogenin-E47 protein complexes . Positive_regulation MYOG IL1B 23971193 2832829 *increased* the level of MyoD , [myogenin] and MHC on the 3rd day of differentiation , without altering the content of the active form of myostatin , as well as it augmented the level of fibronectin , integrin beta1 and full length 100 kDa form of ADAM12 . Positive_regulation MYOG S100B 20069545 2201282 Conversely , silencing expression in myoblast cell lines by RNA interference *resulted* in reduced NF-kappaB activity and enhanced MyoD , [myogenin] and MyHC expression and myotube formation . Positive_regulation MYOG TNF 15256490 1295942 We recently established that impairs the ability of IGF-I to increase protein synthesis and *promote* expression of [myogenin] in myoblasts . Positive_regulation MYOG ZFP57 20235149 2244401 Overexpression of also *inhibited* the expression of myogenic differentiation-specific genes such as MyoD and [myogenin] , and prevented C2C12 myoblast differentiation . Positive_regulation NA EPHB2 14588145 1159802 Also , [NAC] prevented H ( 2 ) O ( 2 ) - and diamide *induced* p38 MAPK , but not activation . Positive_regulation NA ITGB2 18823368 1981537 The expression of increased 1 day after MDMA treatment and glial fibrillary acidic protein *increased* 3 days post-treatment in the striatum and SN but not in the [NAc] , in strict anatomical correlation with dopaminergic damage . Positive_regulation NAALADL1 IL1B 15683451 1370621 The lymph node homing chemokine receptor CCR-7 expression was induced by TNF-alpha + + IL-6 + prostaglandin E2 but was not *induced* by Poly [I:C] + TNF-alpha . Positive_regulation NAALADL1 TNF 15683451 1370620 The lymph node homing chemokine receptor CCR-7 expression was induced by + IL-1beta + IL-6 + prostaglandin E2 but was not *induced* by Poly [I:C] + TNF-alpha . Positive_regulation NACA2 CAPN8 17446485 1729884 We have recently shown that in brain ischemia , and during excitotoxicity triggered by excess glutamate , the irreversible Ca2+ deregulation leading to necrosis is due to *mediated* modulation of the plasma membrane [Na+/Ca2+ exchanger (NCX)] . Positive_regulation NACC1 FOXQ1 24200849 2891707 Ectopic expression of [NAC1] in NACC1 null cells *induced* expression . Positive_regulation NAGLU TNF 18331441 1904675 AlphaTau1 receptor blockers , olmesartan and valsartan ( 10 ( -9 ) -10 ( -6 ) mol/L ) showed a significant reduction on *induced* LDH and [NAG] release in RPTEC . Positive_regulation NAGLU TNF 18331441 1904676 AT2 receptor blocker , PD123319 ( 10 ( -7 ) -10 ( -5 ) mol/L ) also decreased *induced* LDH and [NAG] release in RPTEC . Positive_regulation NAGLU TNF 18331441 1904677 Blockade of both AlphaTau1 and AT2 receptor indicated additional reduction on *induced* LDH and [NAG] release . Positive_regulation NAIP TNF 25149528 2957419 MAVS , caspase1 , IL-18 , and showed increases in expression in AH compared to the controls ( p < 0.05 ) , and [NAIP] expression markedly *increased* in AH compared to the controls ( p < 0.01 ) . Positive_regulation NAMPT EPHB2 19906834 2203532 Both [visfatin] and nicotinamide mononucleotide *induced* activation of both insulin receptor and extracellular signal regulated kinase ( ) 1/2 , with visfatin induced insulin receptor/ERK1/2 activation being inhibited by FK866 . Positive_regulation NAMPT TNF 21542902 2440289 *enhances* hyperbaric oxygen induced [visfatin] expression via JNK pathway in human coronary arterial endothelial cells . Positive_regulation NAMPT TNF 21542902 2440290 HBO induced [visfatin] is *mediated* by and at least in part through JNK pathway . Positive_regulation NANOG FOXA1 19916800 2306998 Furthermore , overexpression of alone in P19 cells stimulates expression of Nestin and *results* in decreased protein levels of [Nanog] . Positive_regulation NANOG ID1 22013995 2539826 We observe that chronic or acute loss of *leads* to a down-regulation of [Nanog] , a critical regulator of self-renewal . Positive_regulation NANOG NES 23762260 2798115 Accordingly , Akt mediated phosphorylation is crucial for the capability of SATB1 to repress [Nanog] expression and to *activate* transcription of Bcl2 and genes . Positive_regulation NANOG TFCP2L1 23942238 2845241 *upregulates* [Nanog] expression and promotes self-renewal in a Nanog dependent manner . Positive_regulation NANOG ZFP57 18687992 1984647 *regulates* [Nanog] through modulation of Oct4 binding . Positive_regulation NANOG ZFP57 18687992 1984701 More interestingly , we further show that *regulates* [Nanog] expression through modulation of Oct4 binding . Positive_regulation NANOG ZFP57 18757296 1985552 was shown to directly *activate* [Nanog] expression by binding to a site in the promoter in very close proximity to the Oct4 and Sox2 binding sites . Positive_regulation NANOG ZFP57 21915945 2497200 Chromatin immunoprecipitation experiments demonstrated that is *required* for [Nanog] binding to its own promoter , suggesting that Nanog associated repressive complex ( es ) involving Zfp281 may fine-tune Nanog expression for pluripotency of ESCs . Positive_regulation NANOS2 EPHB2 16283237 1484076 However , inhibition of *reduced* NFkappaB mediated [Nos2] expression ; Positive_regulation NANOS2 EPHB2 16283237 1484077 ERK activity is required for NFkappaB mediated transcription of Nos2 in insulin producing INS-1E cells , indicating that *regulates* [Nos2] expression by increasing the transactivating capacity of NFkappaB . Positive_regulation NANOS2 IL1B 10772914 686288 RA inhibited *induced* [NOS2] mRNA expression and NO production . Positive_regulation NANOS2 IL1B 10772914 686289 The synthetic retinoid agonists CD336 ( which specifically binds RARalpha ) and CD367 ( which binds all RARs ) but not agonists specific for RARbeta , RARgamma , or RXRs reduced *induced* [NOS2] expression and NO production . Positive_regulation NANOS2 IL1B 10779013 687124 The [NOS-2] activity , assessed by nitrite accumulation , was absent from untreated cultures but was *induced* by and interferon-gamma acting synergistically . Positive_regulation NANOS2 IL1B 11286988 799899 In monolayers , *induced* COX-2 and [NOS II] expression in a dose- and time dependent manner , to produce high prostaglandin E ( 2 ) ( PGE ( 2 ) ) and nitrite ( NO ( 2 ) ( - ) ) levels in an apparently coordinated fashion . Positive_regulation NANOS2 IL1B 11286988 799904 These results show that in chondrocytes : ( i ) COX2 and [NOS II] genes are *induced* sequentially and distinctly by ; Positive_regulation NANOS2 IL1B 11530235 853783 The signaling mechanisms by which *regulates* [NOS-2] and COX-2 genes remain obscure . Positive_regulation NANOS2 IL1B 11530235 853787 The oxidant scavenger pyrrolidine dithiocarbamate abolished *induced* [NOS-2] mRNA accumulation and decreased nitric oxide production in a concentration dependent manner , thus indicating that this antioxidant decreased either the transcription of NOS-2 gene or the stability of NOS-2 mRNA . Positive_regulation NANOS2 IL1B 11530235 853789 Rotenone , another antioxidant that attenuates reactive oxygen species production by inhibiting the mitochondrial electron transport system , failed to inhibit *induced* [NOS-2] and COX-2 mRNA encoding transcripts . Positive_regulation NANOS2 IL1B 11530235 853795 These results indicate that not only transcriptional regulation , but also posttranscriptional events are involved in a redox-sensitive regulation of *induced* [NOS-2] and COX-2 gene expression in the dorsal root ganglia . Positive_regulation NANOS2 IL1B 11751200 898197 EC did not express NOS 2 mRNA or protein when exposed to normoxia or hypoxia unless they were pretreated with interleukin (IL)-1beta and/or tumor necrosis factor (TNF)-alpha for 24 h. *Induction* of [NOS 2] by was significantly attenuated by concomitant exposure of EC to hypoxia or treatment of EC with antioxidants such as tiron , diphenyliodonium , and catalase , suggesting that NOS 2 expression is dependent on the production of reactive oxygen species . Positive_regulation NANOS2 IL1B 11751200 898199 As opposed to the attenuating effect that hypoxia had on dependent *induction* of [NOS 2] gene expression , the concomitant treatment with IL-1beta+TNF-alpha and hypoxia synergistically increased NOS 2 promoter activity 17.6-fold . Positive_regulation NANOS2 IL1B 12427659 1014767 Myocardial tumor necrosis factor , , and [NOS2] *induction* was measured before and 6 hours after LPS challenge . Positive_regulation NANOS2 IL1B 14729054 1198281 Generation of high levels of nitric oxide ( NO ) following *induction* of [NOS2] by triggers beta cell apoptosis in insulin secreting RINm5F cells . Positive_regulation NANOS2 IL1B 16376111 1553939 The NF-kappaBp65-specific siRNA inhibited the expression of NF-kappaBp65 and activation of NF-kappaB , reducing significantly the expression of COX-2 , [NOS-2] and MMP-9 *induced* by and tumor necrosis factor-alpha (TNF-alpha) in cultured chondrocytes . Positive_regulation NANOS2 IL1B 19370157 2058818 A mathematical model developed to understand the complex dynamics of the system predicts two thresholds in the magnitudes of DCS , one for the inhibition of *induced* expression of [NOS2] by DCS at low magnitudes , and second for the DCS induced expression of NOS2 at higher magnitudes . Positive_regulation NANOS2 IL1B 7499354 332928 In vitro , and interferon-gamma *increased* osteopontin mRNA levels in CMEC as well as [NOS2] expression in both CMEC and cardiac myocytes . Positive_regulation NANOS2 IL1B 8557638 347433 *induces* [NOS2] in both , whereas interferon gamma (IFN gamma) induces NOS2 expression in myocytes but not in CMEC . Positive_regulation NANOS2 IL1B 8557638 347435 The farnesyl transferase inhibitor BZA-5B blocked activation of ERK1/ERK2 and *induction* of [NOS2] by IFN gamma and in myocytes . Positive_regulation NANOS2 IL1B 8557638 347441 IL-1 beta and IFN gamma induced NOS2 gene expression in myocytes was also down-regulated by both protein kinase C ( PKC ) desensitization and by the PKC inhibitor bisindolylmaleimide , implicating PKC linked activation of Ras or Raf in the *induction* of [NOS2] by and IFN gamma in cardiac muscle cells . Positive_regulation NANOS2 IL1B 8557638 347443 In CMEC , the MAPK kinase inhibitor PD 98059 blocked activation of ERK1/ERK2 and down-regulated mediated [NOS2] *induction* , whereas activation of ERK2 in the absence of cytokines by okadaic acid , an inhibitor of phosphoserine protein phosphatases , also induced NOS2 mRNA . Positive_regulation NANOS2 IL1B 8557638 347483 These data demonstrate that ERK1/ERK2 activation appears to be necessary for the *induction* of [NOS2] by and IFN gamma in cardiac myocytes and CMEC . Positive_regulation NANOS2 IL1B 8940176 399117 Salicylate also inhibited interferon-gamma plus *induced* [NOS 2] mRNA . Positive_regulation NANOS2 IL1B 9153192 431085 In contrast , treatment of cells with the inhibitor of protein farnesylation , FTI-277 ( 10 microM ) , blocked *induced* [NOS-2] expression at mRNA and protein levels . Positive_regulation NANOS2 IL1B 9153192 431086 The results demonstrate that a farnesylated protein ( s ) mediates *induction* of [NOS-2] , whereas a geranylgeranylated protein ( s ) represses this induction . Positive_regulation NANOS2 KRT38 15353992 1292958 [NOS II] was highly upregulated in *response* to throughout the duration of the study . Positive_regulation NANOS2 STAT4 15459017 1359198 also *enhanced* expression of [nitric oxide synthase 2 (NOS2)] in CTMCs , which brought about increased levels of NO-dependent cytotoxic activity . Positive_regulation NANOS2 TNF 10362638 620083 We conclude that the LPS induced increase in [NOS II] activity and the decrease in ileal muscle contractility are *mediated* by and IL-1 . Positive_regulation NANOS2 TNF 11390433 822520 Maximal expression of [NOS2] after CFA immunization *requires* the presence of functional type I alpha receptor ( TNFR1 ) and interferon gamma . Positive_regulation NANOS2 TNF 11399519 824236 Together , our results show that binding of IRF-1 and NF-kappa B to their respective sites in the distal domain of the NOS2 promoter , creates a potent trans activating complex with the ability to induce [NOS2] transcription synergistically in *response* to simultaneous and IFN-gamma treatment . Positive_regulation NANOS2 TNF 11751200 898196 EC did not express NOS 2 mRNA or protein when exposed to normoxia or hypoxia unless they were pretreated with interleukin (IL)-1beta and/or tumor necrosis factor (TNF)-alpha for 24 h. *Induction* of [NOS 2] by was significantly attenuated by concomitant exposure of EC to hypoxia or treatment of EC with antioxidants such as tiron , diphenyliodonium , and catalase , suggesting that NOS 2 expression is dependent on the production of reactive oxygen species . Positive_regulation NANOS2 TNF 11751200 898198 As opposed to the attenuating effect that hypoxia had on dependent *induction* of [NOS 2] gene expression , the concomitant treatment with IL-1beta+TNF-alpha and hypoxia synergistically increased NOS 2 promoter activity 17.6-fold . Positive_regulation NANOS2 TNF 12427659 1014766 Myocardial , interleukin-1beta (IL-1beta) , and [NOS2] *induction* was measured before and 6 hours after LPS challenge . Positive_regulation NANOS2 TNF 16376111 1553938 The NF-kappaBp65-specific siRNA inhibited the expression of NF-kappaBp65 and activation of NF-kappaB , reducing significantly the expression of COX-2 , [NOS-2] and MMP-9 *induced* by interleukin-1beta (IL-1beta) and in cultured chondrocytes . Positive_regulation NANOS2 TNF 17588258 1786270 Furthermore , and LPS significantly *induced* [NOS2] expression . Positive_regulation NANOS2 TNF 19470832 2107469 In a mouse model of muscle wasting , *induces* oxidative stress and [nitric oxide synthase-2 (NOS2)] and decreases myogenin , Jun-D , and creatinine kinase muscle isoform (CKM) expression . Positive_regulation NANOS2 TNF 21926986 2497364 Expression of [NOS2] and production of nitric oxide paralleled the activation of T cells and *required* a tripartite synergism of interferon-? , and direct contact with activated T cells . Positive_regulation NANOS2 TNF 22044243 2533918 In contrast to tumour necrosis factor-a (TNF-a) alone or CD40 stimulation alone , simultaneous stimulation of mouse macrophages through CD40 ligation and *led* to up-regulation of [NOS2] and nitric oxide production . Positive_regulation NANOS2 TNF 22044243 2533920 CD40 plus *up-regulated* [NOS2] independently of interferon-? , interferon-a/ß and interleukin-1 . Positive_regulation NANOS2 TNF 7544539 318316 We conclude that 1 ) and IFN-gamma *induce* the expression of vascular smooth muscle [NOS II] and production of NO in RMIC , and 2 ) NO acts as an autocrine activator of the soluble guanylyl cyclase in RMIC . Positive_regulation NANOS2 TNF 8700134 375438 [NOS2] activity was *induced* by lipopolysaccharide , IL-1 beta , , and IFN gamma but not by IL-6 . Positive_regulation NANOS2 TNF 8763035 343598 Thus , expression of [NOS-2] is *induced* by IFN-gamma , and IL-1 as well as microbial products whereas IL-4 , IL-10 and TGF-beta down-regulate its synthesis . Positive_regulation NANOS3 GPR115 16997880 1628597 These data support our hypothesis that increased Po ( 2 ) at birth promotes dissociation of caveolin-1 and NOS-3 , with an increase in their activities , and that PKC and an oxygen-sensitive cell surface *regulate* caveolin-1 and [NOS-3] interactions in fetal and neonatal lung MVECs . Positive_regulation NANOS3 GPR132 16997880 1628586 These data support our hypothesis that increased Po ( 2 ) at birth promotes dissociation of caveolin-1 and NOS-3 , with an increase in their activities , and that PKC and an oxygen-sensitive cell surface *regulate* caveolin-1 and [NOS-3] interactions in fetal and neonatal lung MVECs . Positive_regulation NANOS3 GPR87 16997880 1628666 These data support our hypothesis that increased Po ( 2 ) at birth promotes dissociation of caveolin-1 and NOS-3 , with an increase in their activities , and that PKC and an oxygen-sensitive cell surface *regulate* caveolin-1 and [NOS-3] interactions in fetal and neonatal lung MVECs . Positive_regulation NANOS3 PDE5A 21421555 2416746 Treatment of human endothelium with PDE5A inhibitors resulted in a significant increase in NOS3 activity , whereas overexpression of using an adenoviral vector , both in vivo and in cell culture , *resulted* in decreased [NOS3] activity and endothelium dependent vasodilation . Positive_regulation NANOS3 TNF 9537427 497544 These results suggest that may *regulate* [NOS3] expression in the portal hypertensive stomach and that anti-TNF-alpha treatment may ameliorate the pathophysiological abnormalities of portal hypertensive gastric mucosa . Positive_regulation NAPA ITGAL 11259095 795662 [NaPa] *induced* also an increased expression of both and Intercellular Adhesion Molecule-1 ( ICAM-1 ) , which was obvious from 18 hour incubation with NaPa for the MDA-MB-231 cells , but was delayed ( 3 days ) for MCF-7 and MCF-7 ras . Positive_regulation NAV1 TNF 20638792 2329281 Furthermore , inhibition of synthesis , which prevented neuropathic pain , strongly *inhibited* the up-regulation of [Nav1] .3 and Nav1 .8 . Positive_regulation NAV1 TNF 20858468 2342891 As our previous work has shown that up-regulation of tumor necrosis factor-alpha ( TNF-a ) in DRG is responsible for the re-expression of Nav1 .3 in uninjured DRG neurons following L5 ventral root injury , we investigated whether activation of NF-?B is essential for the *up-regulation* of [Nav1] .3 by . Positive_regulation NAV1 TNF 24445633 2901576 Western blot analysis showed that *increased* [NaV1] .7 protein up to 166 % ± 24 % ( N = 5 , corrected P < 0.0001 ) in adrenal chromaffin cells , concentration- and time-dependently . Positive_regulation NBL1 IL1B 7506289 237764 *stimulated* production of [NO2-/NO3-] ( NOx ) in a time dependent manner and both NOx and cyclic GMP formation were stimulated in a dose dependent manner by IL-1 beta . Positive_regulation NBL1 IL1B 7594493 334775 Finally , at high doses also *induced* iNOS mRNA and significant NO2- + [NO3-] production in cultures of primary human hepatocytes . Positive_regulation NBL1 IL1B 7686532 222262 NG-Monomethyl L-arginine completely blocked the *induced* [NO2-/NO3-] production , the effect of which was reversed by L-arginine but not by D-arginine . Positive_regulation NBL1 IL1B 7686532 222263 Dexamethasone inhibited the *induced* [NO2-/NO3-] production in a dose dependent manner ( 10 ( -9 ) to 10 ( -7 ) M ) and the interleukin-1 beta-inducible nitric oxide synthase messenger RNA levels . Positive_regulation NBL1 IL1B 8760140 378027 Stimulation with IL-1 beta and TNF-alpha plus H2O2 or and LPS plus H2O2 *increased* the synthesis of NO2- and [NO3-] by 3.8- and 3.5-fold , respectively . Positive_regulation NBL1 TNF 19596830 2122981 *increased* NO ( 2 ) [/NO(3)] production in every examined phase in the ampulla and on Days 2-3 in the isthmus . Positive_regulation NBL1 TNF 8760140 378026 Stimulation with IL-1 beta and plus H2O2 or IL-1 beta and LPS plus H2O2 *increased* the synthesis of NO2- and [NO3-] by 3.8- and 3.5-fold , respectively . Positive_regulation NCAM1 EPHB2 12694399 1080734 These results indicate that D2R induced NF-kappaB activation through may be *involved* in activation of the [NCAM] promoter , and additionally that other protein kinases such as CaM KII and p38 MAPK also regulate NCAM expression . Positive_regulation NCAM1 EPHB2 18656513 1972805 Relative *role* of upstream regulators of Akt , and CREB in [NCAM-] and FGF2 mediated signalling . Positive_regulation NCAM1 FOXO1 9721857 528784 *Up-regulation* of MET but not [neural cell adhesion molecule] expression by the fusion protein in alveolar rhabdomyosarcoma . Positive_regulation NCAM1 PLAT 10603431 575019 These results suggest that up-regulated may *contribute* to the degradation of [PSA-NCAM] . Positive_regulation NCAM1 TLR7 23679126 2805817 stimulation significantly *increased* IDO protein level in CD14 ( + ) , [CD56] ( + ) , CD1c ( + ) , CD11c ( + ) , and CD123 ( + ) myeloid cells . Positive_regulation NCAM2 EPHB2 12694399 1080737 These results indicate that D2R induced NF-kappaB activation through may be *involved* in activation of the [NCAM] promoter , and additionally that other protein kinases such as CaM KII and p38 MAPK also regulate NCAM expression . Positive_regulation NCAM2 EPHB2 18656513 1972809 Relative *role* of upstream regulators of Akt , and CREB in [NCAM-] and FGF2 mediated signalling . Positive_regulation NCAM2 FOXO1 9721857 528786 *Up-regulation* of MET but not [neural cell adhesion molecule] expression by the fusion protein in alveolar rhabdomyosarcoma . Positive_regulation NCAM2 PLAT 10603431 575020 These results suggest that up-regulated may *contribute* to the degradation of [PSA-NCAM] . Positive_regulation NCF1 EPHB2 23348708 2747551 Taken together , these results suggest that the *mediated* Ser phosphorylation of [p47(phox)] is not implicated in the assembly of NADPH oxidase or O2 ( •- ) generation , and that O2 ( •- ) generation is partly attributable to p38 MAPK signaling through mechanisms other than p47(phox) activation , Akt activation and S100A9 membrane recruitment in fMLP stimulated neutrophils . Positive_regulation NCF1 FAS 18471522 1910394 In quiescent HSCs , *led* to a rapid phosphorylation of the epidermal growth factor receptor (EGFR) , extracellular signal regulated kinase ( Erk ) , and c-Src , but not of c-Jun-N-terminal kinase and [p47(phox)] , an activating subunit of reduced nicotinamide adenine dinucleotide phosphate oxidase . Positive_regulation NCF1 IL1B 2648570 108826 Human endothelial cells produced a [neutrophil chemotactic factor (NCF)] upon *stimulation* with tumor necrosis factor-alpha (TNF-alpha) , , or lipopolysaccharide (LPS) . Positive_regulation NCF1 ITGB2 21248133 2380018 The treatment of microglia with HMGB1 led to membrane translocation of [p47(phox)] ( a cytosolic subunit of NADPH oxidase ) and consequent superoxide release , which *required* the presence of . Positive_regulation NCF1 TNF 12016268 942391 Stimulation of HPAE cells with *resulted* in the phosphorylation of [p47(phox)] and its association with gp91(phox) . Positive_regulation NCF1 TNF 12016268 942392 Inhibition of PKCzeta by multiple pharmacological and genetic approaches prevented the *induced* phosphorylation of [p47(phox)] , and its translocation to the membrane . Positive_regulation NCF1 TNF 12807699 1185277 treatment ( 50 ng/ml for 4.0 h ) *induced* 1 ) [p47phox] translocation , 2 ) an increase in p22phox protein , 3 ) increased localization of p47phox with p22phox , 4 ) O2-* generation , and 5 ) increased permeability to albumin . Positive_regulation NCF1 TNF 12807699 1185279 p22phox antisense oligonucleotide prevented the *induced* effect on p22phox , [p47phox] , O2-* , and permeability . Positive_regulation NCF1 TNF 14530365 1149346 *induces* phosphorylation of [p47(phox)] in human neutrophils : partial phosphorylation of p47phox is a common event of priming of human neutrophils by TNF-alpha and granulocyte-macrophage colony stimulating factor . Positive_regulation NCF1 TNF 14530365 1149349 Only and GM-CSF *induced* a clear [p47(phox)] phosphorylation . Positive_regulation NCF1 TNF 14530365 1149353 A neutralizing Ab against the p55 TNF receptor , contrary to a neutralizing Ab against the p75 TNF receptor , inhibited *induced* [p47(phox)] phosphorylation . Positive_regulation NCF1 TNF 14530365 1149354 These findings show that , via its p55 receptor , *induces* a protein tyrosine kinase dependent selective phosphorylation of [p47(phox)] on specific serines . Positive_regulation NCF1 TNF 16720733 1575888 We found that IL-10 selectively inhibited GM-CSF- but not *induced* [p47PHOX] phosphorylation in a concentration dependent manner . Positive_regulation NCF1 TNF 17197441 1702261 Additionally , *induced* the association of CD11b/CD18 with the NADPH oxidase subunit Nox2 ( gp91(phox) ) and phosphorylation of [p47(phox)] , indicating the CD11b/CD18 dependence of NADPH oxidase activation . Positive_regulation NCF1 TNF 17537988 1784154 Pharmacological inhibitors of NF-kappaB activation blocked *induced* up-regulation of [NCF1] , NCF2 , and CYBB message , which correlated with a reduction in expression of the corresponding oxidase proteins and decreased O2*- production . Positive_regulation NCF1 TNF 19552846 2099464 and alpha-ZAL pretreatment attenuated the *induced* [p47(phox)] mRNA expression by 63.0 % , and also markedly inhibited the p47(phox) protein expression . Positive_regulation NCF1 TNF 19801500 2187004 In adherent neutrophils , *triggered* a time dependent association of delta-PKC with [p47phox] , which was associated with p47phox phosphorylation , indicating a role for delta-PKC in regulating O ( 2 ) ( - ) production at the level of p47phox . Positive_regulation NCF1 TNF 23073791 2690039 In vitro *increased* superoxide production and [p47(phox)] expression in HAECs , and such increases could be ameliorated by the specific PKC-? inhibitor . Positive_regulation NCF1 TNF 2648570 108825 Human endothelial cells produced a [neutrophil chemotactic factor (NCF)] upon *stimulation* with , interleukin-1 beta (IL-1 beta) , or lipopolysaccharide (LPS) . Positive_regulation NCF2 IL1B 19375465 2106410 These compounds also suppressed *induced* ERK1/2 activation and translocation of the NADPH oxidase subunit [p67 phox] from cytosol to membrane fraction . Positive_regulation NCF2 IL1B 2648570 108828 Human endothelial cells produced a [neutrophil chemotactic factor (NCF)] upon *stimulation* with tumor necrosis factor-alpha (TNF-alpha) , , or lipopolysaccharide (LPS) . Positive_regulation NCF2 TNF 17537988 1784157 Pharmacological inhibitors of NF-kappaB activation blocked induced *up-regulation* of NCF1 , [NCF2] , and CYBB message , which correlated with a reduction in expression of the corresponding oxidase proteins and decreased O2*- production . Positive_regulation NCF2 TNF 2648570 108827 Human endothelial cells produced a [neutrophil chemotactic factor (NCF)] upon *stimulation* with , interleukin-1 beta (IL-1 beta) , or lipopolysaccharide (LPS) . Positive_regulation NCF4 IL1B 2648570 108830 Human endothelial cells produced a [neutrophil chemotactic factor (NCF)] upon *stimulation* with tumor necrosis factor-alpha (TNF-alpha) , , or lipopolysaccharide (LPS) . Positive_regulation NCF4 TNF 2648570 108829 Human endothelial cells produced a [neutrophil chemotactic factor (NCF)] upon *stimulation* with , interleukin-1 beta (IL-1 beta) , or lipopolysaccharide (LPS) . Positive_regulation NCK1 NGFR 1333046 204323 The phosphorylation of [Nck] is also enhanced in *response* to stimulation of the in PC12 cells , the T-cell receptor complex in Jurkat cells , the membrane immunoglobulin M in Daudi cells , and the low-affinity immunoglobulin G receptor ( Fc gamma RII ) in U937 cells . Positive_regulation NCKIPSD TNF 9584837 504445 The PGHS-2 mRNA decayed with an apparent half-life of 1 h in *stimulated* [WISH] cells . Positive_regulation NCOA2 TNF 11489729 845379 Long-term stimulation by could *increase* ARA55 and [TIF2] expression in LNCaP cells . Positive_regulation NCOA3 EPHB2 12824291 1113644 These results indicate that *dependent* [R-Smad] linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells . Positive_regulation NCOR1 INPP4B 21224358 2379459 Optimal induction of by an androgen receptor *required* the expression of the transcriptional coactivator [NCoR] . Positive_regulation NCOR1 TLR7 21849441 2486237 Treatment with PPAR? and LXR ligands , but not GR ligands , prevented this *induced* clearance of [NCoR] from the LTR . Positive_regulation NCOR2 CCND1 21901538 2521954 We also found that when down regulation of p65 , the expression of and Bc1-2 decreased , and the expression of [SMRT] *increased* in vitro and vivo . Positive_regulation NDC80 MMP7 19019417 2016903 LPA2 mediates LPA stimulated [HEC1A] invasion and the subsequent *activation* of . Positive_regulation NDE1 STK39 18083840 1837032 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation NDEL1 STK39 18083840 1837047 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation NDFIP1 EPHB2 23851689 2825150 Ndfip1 and IL-2 have a similar expression pattern , and , following TCR stimulation , expression of both [Ndfip1] and IL-2 *requires* the activity of NFAT and . Positive_regulation NDOR1 EPHB2 15379998 1298344 [NR1] phosphorylation induced by BDNF was *blocked* by a TrkB inhibitor , an inhibitor and a PKC inhibitor but not a PKA inhibitor . Positive_regulation NDOR1 IL1B 18554806 1934785 The results suggest that spinal *enhances* [NR1] phosphorylation to facilitate bone cancer pain . Positive_regulation NDOR1 MMP7 18644839 1979356 Moreover , studies with recombinant protein show that *mediated* cleavage of [NR1] occurs at amino acid 517 , which is extracellular and just distal to the first transmembrane domain . Positive_regulation NDP FZD4 15035989 1223845 We show here that Norrin and Fz4 function as a ligand-receptor pair based on ( 1 ) the similarity in vascular phenotypes caused by Norrin and Fz4 mutations in humans and mice , ( 2 ) the specificity and high affinity of Norrin-Fz4 binding , ( 3 ) the high efficiency with which [Norrin] *induces* and Lrp dependent activation of the classical Wnt pathway , and ( 4 ) the signaling defects displayed by disease associated variants of Norrin and Fz4 . Positive_regulation NDP FZD4 24186977 2864272 Instead of inducing Fz4 dimerization , [Norrin] *induces* the formation of a ternary complex with and Lrp5/6 by binding to their respective extracellular domains . Positive_regulation NDRG1 CCND1 23897809 2839724 However , but not Cdk4 *promoted* the kinase activity of [NDR1/2] . Positive_regulation NDRG1 FAS 19062280 2001798 Here we report that and TNF-alpha receptor stimulation *activates* human [NDR1/2] by promoting phosphorylation at the hydrophobic motif ( Thr444/442 ) . Positive_regulation NDRG1 FAS 19062280 2001803 receptor stimulation *promoted* direct phosphorylation and activation of [NDR1/2] by the mammalian STE20-like kinase 1 (MST1) , a downstream effector of RASSF1A . Positive_regulation NDRG1 GPNMB 22290289 2636612 overexpression *induced* the gene expressions of N-myc downstream regulated gene 1 ( [Ndrg1] ) and maspin in PC-3 cells . Positive_regulation NDRG1 TNF 19062280 2001797 Here we report that Fas and receptor stimulation *activates* human [NDR1/2] by promoting phosphorylation at the hydrophobic motif ( Thr444/442 ) . Positive_regulation NEB EPHB2 17562849 1778628 The results suggest that activation of PKC inhibits alpha ( 1 ) -adrenoceptor mediated contractions in PUA through down-regulation of the thick-filament pathway and decreased myosin light chain phosphorylation , but that it enhances the contractions in NPUA through its effect on the [thin-filament] regulatory pathway and *activation* of and actin polymerization . Positive_regulation NEB TMOD1 12975349 1139829 These studies indicate that the interaction of with tropomyosin is *critical* for [thin filament] stability . Positive_regulation NEDD1 AXIN2 19390532 2089376 These results suggest that , but not Axin2 , is *involved* in microtubule nucleation by forming a complex with [gamma-tubulin] at the centrosome . Positive_regulation NEDD4L SLC38A3 12788082 1097135 It is concluded that is a *target* for the ubiquitin ligase [Nedd4-2] , which is inactivated by the serum and glucocorticoid inducible kinase SGK1 , its isoform SGK3 , and protein kinase B . Positive_regulation NEDD9 AHR 19648964 2143277 Here , we show that dioxin mediated activation of *induces* [Nedd9/Hef1/Cas-L] , a member of the Cas protein family recently identified as a metastasis marker . Positive_regulation NEDD9 BCAR3 21262352 2403052 Although both wildtype and R743A *induced* phosphorylation of p130Cas and the related adapter protein [HEF1/NEDD9] , chimeric NSP3 : BCAR3 experiments demonstrate that such phosphorylation does not correlate with BCAR3 induced anti-estrogen resistance or lamellipodia formation . Positive_regulation NEDD9 BCR 9020138 412629 Here we show that ligation of either beta1 integrin or on human tonsillar B cells and B cell lines *promoted* tyrosine phosphorylation of [HEF1] . Positive_regulation NEDD9 BCR 9020138 412632 Interestingly , pretreatment of tonsillar B cells with cytochalasin B dramatically reduced both integrin- and *induced* [HEF1] phosphorylation , suggesting that some component of the BCR mediated signaling pathway is closely linked with a cytoskeletal reorganization . Positive_regulation NEDD9 CALCA 10455189 638620 *induces* the association of [HEF1] , paxillin , and focal adhesion kinase . Positive_regulation NEDD9 CALCA 10455189 638622 The *induced* tyrosine phosphorylation of [HEF1] increased in a time- and dose dependent manner . Positive_regulation NEDD9 CALCA 10455189 638623 Increasing cytosolic Ca ( 2+ ) with ionomycin stimulated HEF1 phosphorylation and preventing any calcitonin induced change in cytosolic calcium by a combination of BAPTA and extracellular EGTA completely blocked the *induced* tyrosine phosphorylation of [HEF1] . Positive_regulation NEDD9 CALCA 10455189 638626 Pretreatment with cytochalasin D , which disrupts actin microfilaments , prevented the *induced* [HEF1] and paxillin phosphorylation . Positive_regulation NEDD9 CALCA 10455189 638628 In conclusion , the *stimulated* tyrosine phosphorylation of [HEF1] is mediated by calcium- and protein kinase C-dependent mechanisms and requires the integrity of the actin cytoskeleton . Positive_regulation NEDD9 CALCA 10954702 744346 Integrin engagement , the actin cytoskeleton , and c-Src are required for the *induced* tyrosine phosphorylation of paxillin and [HEF1] , but not for calcitonin induced Erk1/2 phosphorylation . Positive_regulation NEDD9 CALCA 10954702 744349 We have previously shown that in a HEK-293 cell line that overexpresses the C1a isoform of the calcitonin receptor ( C1a-HEK ) , *induces* the tyrosine phosphorylation of the focal adhesion associated proteins [HEF1] ( a p130 ( Cas ) -like docking protein ) , paxillin , and focal adhesion kinase and that it also stimulates the phosphorylation and activation of Erk1 and Erk2 . Positive_regulation NEDD9 CALCA 10954702 744353 Overexpression of wild-type c-Src increased *induced* paxillin and [HEF1] phosphorylation , whereas overexpression of kinase-dead Src or Src lacking a functional SH2 domain inhibited the calcitonin stimulated tyrosine phosphorylation of these proteins . Positive_regulation NEDD9 CALCA 10954702 744355 Overexpression of Src lacking the SH3 domain did not affect the *induced* phosphorylation of paxillin and [HEF1] . Positive_regulation NEDD9 CALCA 10954702 744365 Furthermore , inhibition of Erk1 and Erk2 phosphorylation had no effect on the *induced* phosphorylation of paxillin and [HEF1] . Positive_regulation NEDD9 CALCA 12231407 988661 *induces* the association and tyrosine phosphorylation of focal adhesion kinase ( FAK ) , paxillin , and [HEF1] in HEK-293 cells that overexpress the calcitonin receptor ( C1a-HEK ) , but the hormone 's effect on these adhesion related proteins in osteoclasts is not known . Positive_regulation NEDD9 CBL 21799517 2472610 In addition , deficiency *reduces* both p50 and [p105] levels , which have been shown to modulate the stimulatory function of NF-?B . Positive_regulation NEDD9 CD3D 10447714 576821 We have previously shown that engagement of the complex with anti-CD3 antibody *induces* tyrosine phosphorylation of [p105CasL] ( CasL ) , a member of the p130Cas docking protein family . Positive_regulation NEDD9 CD3E 10447714 576822 We have previously shown that engagement of the complex with anti-CD3 antibody *induces* tyrosine phosphorylation of [p105CasL] ( CasL ) , a member of the p130Cas docking protein family . Positive_regulation NEDD9 CD3G 10447714 576823 We have previously shown that engagement of the complex with anti-CD3 antibody *induces* tyrosine phosphorylation of [p105CasL] ( CasL ) , a member of the p130Cas docking protein family . Positive_regulation NEDD9 CD79A 9020138 412630 Here we show that ligation of either beta1 integrin or on human tonsillar B cells and B cell lines *promoted* tyrosine phosphorylation of [HEF1] . Positive_regulation NEDD9 CD79B 9020138 412631 Here we show that ligation of either beta1 integrin or on human tonsillar B cells and B cell lines *promoted* tyrosine phosphorylation of [HEF1] . Positive_regulation NEDD9 CD9 24466195 2907760 Finally , gene depletion of *resulted* in elevated protein levels and tyrosine phosphorylation of FAK and [Cas-L] , which are downstream of ß1 integrin , while depletion of CD26 led to a reduction in the levels of these molecules . Positive_regulation NEDD9 CDH13 12189134 992646 Digestion with specific phosphatases indicated that the [p115HEF1] *resulted* from serine/threonine phosphorylation of . Positive_regulation NEDD9 CHUK 16980301 1640380 Upon LPS stimulation , *promotes* phosphorylation and degradation of NFkappaB1 [p105] ( p105 ) , which releases TPL2 ( a MAP3K ) , which phosphorylates MEK1/2 , which in turn phosphorylates ERK1/2 . Positive_regulation NEDD9 CHUK 22435554 2573409 Agonist stimulation releases TPL-2 from p105-inhibition by *mediated* phosphorylation of [p105] , which triggers degradation of p105 by the proteasome . Positive_regulation NEDD9 CHUK 22733995 2639215 Unexpectedly , TPL-2 promoted soluble TNF production independently of *induced* [p105] phosphorylation and its ability to activate ERK , which has important implications for the development of anti-inflammatory drugs targeting TPL-2 . Positive_regulation NEDD9 CNTN2 7966593 279725 We demonstrate here that can *induce* translocation of members of the NF-kappa B family retained in the cytoplasm through their interaction with either [p105] or p100 . Positive_regulation NEDD9 CRKL 9498705 477254 Therefore , is *involved* in the formation of a [HEF1-CrkL-C3G] ternary complex in B-cells , suggesting that it is likely to play an important role , allowing the propagation of the stimulation initiated by both BCR and beta1 integrin ligation . Positive_regulation NEDD9 EGFR 23037767 2698406 We showed that tyrosine phosphorylation of [NEDD9] was *reduced* by the inhibition of in NSCLC cell lines . Positive_regulation NEDD9 EPHB2 16394015 1506058 Activation of *requires* both [p50/p105] and the MAPK kinase kinase , Tpl-2 . Positive_regulation NEDD9 EPHB2 22733995 2639209 *Activation* of signaling by IKK induced [p105] proteolysis , therefore , induced a negative feedback loop to downregulate NF-?B dependent expression of the proinflammatory cytokine interleukin-12 (IL-12) . Positive_regulation NEDD9 FCGR1A 9820532 547552 cross linking of U937IF cells *results* in the tyrosine phosphorylation of Cbl , Crkl , and [Hef-1] , an increase in the association of Crkl with Cbl via direct SH2 domain interaction and increased Crkl-Hef-1 binding . Positive_regulation NEDD9 FYN 10447714 576819 and Lck tyrosine kinases *regulate* tyrosine phosphorylation of [p105CasL] , a member of the p130Cas docking protein family , in T-cell receptor mediated signalling . Positive_regulation NEDD9 GSK3B 12871932 1142271 *regulates* NF-kappa [B1/p105] stability . Positive_regulation NEDD9 IKBKB 11297557 819956 By using a specific anti-phosphopeptide antibody , it was confirmed that overexpression *induces* serine 927 phosphorylation of co-transfected [p105] and that endogenous p105 is also rapidly phosphorylated on this residue after TNFalpha or IL-1alpha stimulation . Positive_regulation NEDD9 IKBKB 19754427 2153307 In these cells IL-1 does not activate or *induce* the phosphorylation of [p105/NF-kappaB1] , and nor does the IKKbeta inhibitor PS1145 prevent the IL-1 induced activation of transfected Tpl2 . Positive_regulation NEDD9 IKBKB 22435554 2573410 Agonist stimulation releases TPL-2 from p105-inhibition by *mediated* phosphorylation of [p105] , which triggers degradation of p105 by the proteasome . Positive_regulation NEDD9 IKBKB 22733995 2639216 Unexpectedly , TPL-2 promoted soluble TNF production independently of *induced* [p105] phosphorylation and its ability to activate ERK , which has important implications for the development of anti-inflammatory drugs targeting TPL-2 . Positive_regulation NEDD9 IKBKG 22435554 2573411 Agonist stimulation releases TPL-2 from p105-inhibition by *mediated* phosphorylation of [p105] , which triggers degradation of p105 by the proteasome . Positive_regulation NEDD9 IKBKG 22733995 2639217 Unexpectedly , TPL-2 promoted soluble TNF production independently of *induced* [p105] phosphorylation and its ability to activate ERK , which has important implications for the development of anti-inflammatory drugs targeting TPL-2 . Positive_regulation NEDD9 IL1A 11297557 819954 Tumor necrosis factor alpha (TNFalpha) and *stimulate* [p105] degradation , releasing associated Rel subunits to translocate into the nucleus . Positive_regulation NEDD9 IL1A 19754427 2153308 In these cells IL-1 does not activate IKKbeta or *induce* the phosphorylation of [p105/NF-kappaB1] , and nor does the IKKbeta inhibitor PS1145 prevent the induced activation of transfected Tpl2 . Positive_regulation NEDD9 IL4 21734075 2461447 Instead , we found that inhibited alternative NF-?B signaling and *induced* [p105/50] expression . Positive_regulation NEDD9 ITCH 15051726 1265231 forms a complex with both Smad3 and HEF1 through its WW domains in a TGF-beta independent manner and *regulates* [HEF1] ubiquitination and degradation , which can be enhanced by TGF-beta stimulation . Positive_regulation NEDD9 MAP3K8 19754427 2153309 In these cells IL-1 does not activate IKKbeta or *induce* the phosphorylation of [p105/NF-kappaB1] , and nor does the IKKbeta inhibitor PS1145 prevent the IL-1 induced activation of transfected . Positive_regulation NEDD9 MAP3K8 22733995 2639210 *Activation* of signaling by IKK induced [p105] proteolysis , therefore , induced a negative feedback loop to downregulate NF-?B dependent expression of the proinflammatory cytokine interleukin-12 (IL-12) . Positive_regulation NEDD9 NOS1 14997001 1236900 Non-receptor type protein tyrosine kinase inhibitors , PP2 and herbimycin A , enzymatic antioxidants and a inhibitor *prevented* the phosphorylation of p80 and [p105] when sperm were incubated with fetal cord serum ultrafiltrate . Positive_regulation NEDD9 NOS2 14997001 1236901 Non-receptor type protein tyrosine kinase inhibitors , PP2 and herbimycin A , enzymatic antioxidants and a inhibitor *prevented* the phosphorylation of p80 and [p105] when sperm were incubated with fetal cord serum ultrafiltrate . Positive_regulation NEDD9 NOS3 14997001 1236902 Non-receptor type protein tyrosine kinase inhibitors , PP2 and herbimycin A , enzymatic antioxidants and a inhibitor *prevented* the phosphorylation of p80 and [p105] when sperm were incubated with fetal cord serum ultrafiltrate . Positive_regulation NEDD9 NPY6R 14997001 1236903 Non-receptor type protein tyrosine kinase inhibitors , and herbimycin A , enzymatic antioxidants and a nitric oxide synthase inhibitor *prevented* the phosphorylation of p80 and [p105] when sperm were incubated with fetal cord serum ultrafiltrate . Positive_regulation NEDD9 PTK2 14997001 1236904 Non-receptor type inhibitors , PP2 and herbimycin A , enzymatic antioxidants and a nitric oxide synthase inhibitor *prevented* the phosphorylation of p80 and [p105] when sperm were incubated with fetal cord serum ultrafiltrate . Positive_regulation NEDD9 PTK2B 9242628 446087 While a catalytically active was *required* for both p130 ( Cas ) and [HEF1] , phosphorylation of p130 ( Cas ) , but not of HEF1 , was dependent on an intact autophosphorylation site ( Tyr402 ) on RAFTK . Positive_regulation NEDD9 PTK2B 9242628 446089 These data suggest that itself is *sufficient* for [HEF1] phosphorylation , whereas a cooperation between RAFTK and Src kinases is required for the complete phosphorylation of p130 ( Cas ) . Positive_regulation NEDD9 PTK6 14997001 1236905 Non-receptor type inhibitors , PP2 and herbimycin A , enzymatic antioxidants and a nitric oxide synthase inhibitor *prevented* the phosphorylation of p80 and [p105] when sperm were incubated with fetal cord serum ultrafiltrate . Positive_regulation NEDD9 PTK7 14997001 1236906 Non-receptor type inhibitors , PP2 and herbimycin A , enzymatic antioxidants and a nitric oxide synthase inhibitor *prevented* the phosphorylation of p80 and [p105] when sperm were incubated with fetal cord serum ultrafiltrate . Positive_regulation NEDD9 RBL2 10982822 732016 Expression of the E2 protein also led to posttranscriptional increase in the level of E2F4 , p105 ( Rb ) , and and *induced* the formation of nuclear E2F4-p130 and [E2F4-p105] ( Rb ) complexes . Positive_regulation NEDD9 SMAD3 15051726 1265226 The interaction of with HEF1 *induces* [HEF1] proteasomal degradation , which was further enhanced by TGF-beta stimulation . Positive_regulation NEDD9 SP1 9151857 430869 To address the specific *role* of in p65 and [p105/p50] promoter transactivation by HCMV , we mutated both promoters . Positive_regulation NEDD9 SRC 10954702 744345 Integrin engagement , the actin cytoskeleton , and are *required* for the calcitonin induced tyrosine phosphorylation of paxillin and [HEF1] , but not for calcitonin induced Erk1/2 phosphorylation . Positive_regulation NEDD9 SRC 12189134 992649 These findings suggest that TGF-beta1 regulates HEF1 gene expression and that [HEF1] phosphorylation is *dependent* on cell adhesion and kinase activity . Positive_regulation NEDD9 SRC 22328516 2592245 The metastasis gene [NEDD9] product *acts* through integrin ß3 and to promote mesenchymal motility and inhibit amoeboid motility . Positive_regulation NEDD9 STK11 23074285 2706736 Mechanistically , negatively *regulated* [NEDD9] transcription by promoting cytosolic translocation of CRTC1 from the nucleus . Positive_regulation NEDD9 TGFB1 12189134 992636 Our studies reveal that is a potent *inducer* of [HEF1] gene transcription in human dermal fibroblasts . Positive_regulation NEDD9 TGFB1 12189134 992638 promoted HEF1 expression in a dose dependent manner and *resulted* in a 16-fold increase in [HEF1] protein level . Positive_regulation NEDD9 TGFB1 12189134 992639 *had* no effect on the stability of either [HEF1] protein or mRNA . Positive_regulation NEDD9 TGFB1 12189134 992641 The *induced* [HEF1] expression was independent of cell adhesion and resistant to cytoskeleton disruption . Positive_regulation NEDD9 TGFB1 12189134 992643 *increased* levels of both p105 and p115 [HEF1] in adherent fibroblasts . Positive_regulation NEDD9 TGFB1 12189134 992650 These findings suggest that *regulates* [HEF1] gene expression and that HEF1 phosphorylation is dependent on cell adhesion and Src kinase activity . Positive_regulation NEDD9 TNF 11237861 790427 Although the expression of the [p105] gene , another known target for NF-kappaB , was *increased* by in the absence of TSH , the presence of TSH further increased the mRNA level . Positive_regulation NEDD9 TNF 11297557 819953 and interleukin-1alpha (IL-1alpha) *stimulate* [p105] degradation , releasing associated Rel subunits to translocate into the nucleus . Positive_regulation NEDD9 TNF 11976329 954024 Stimulation of cells with *triggers* NF-kappaB1 [p105] proteolysis , releasing associated Rel subunits to translocate into the nucleus and modulate target gene expression . Positive_regulation NEDD9 TNF 11976329 954027 Phosphorylation of serine 927 within the p105 PEST region by the IkappaB kinase (IKK) complex is required to promote [p105] proteolysis in *response* to stimulation . Positive_regulation NEDD9 TNFSF11 20682015 2335350 Furthermore , GA suppressed LPS- and *stimulated* phosphorylation of nuclear factor-?B [p105] in vitro . Positive_regulation NEDD9 WNT1 21317929 2437777 Chromatin immunoprecipitation ( ChIP ) assays and promoter analyses revealed three functional T-cell factor (TCF) binding sites in the promoter of HEF1 responsible for [HEF1] *induction* by signaling . Positive_regulation NEDD9 WNT11 21317929 2437778 Chromatin immunoprecipitation ( ChIP ) assays and promoter analyses revealed three functional T-cell factor (TCF) binding sites in the promoter of HEF1 responsible for [HEF1] *induction* by signaling . Positive_regulation NEDD9 WNT16 21317929 2437783 Chromatin immunoprecipitation ( ChIP ) assays and promoter analyses revealed three functional T-cell factor (TCF) binding sites in the promoter of HEF1 responsible for [HEF1] *induction* by signaling . Positive_regulation NEDD9 WNT2 21317929 2437779 Chromatin immunoprecipitation ( ChIP ) assays and promoter analyses revealed three functional T-cell factor (TCF) binding sites in the promoter of HEF1 responsible for [HEF1] *induction* by signaling . Positive_regulation NEDD9 WNT3 21317929 2437780 Chromatin immunoprecipitation ( ChIP ) assays and promoter analyses revealed three functional T-cell factor (TCF) binding sites in the promoter of HEF1 responsible for [HEF1] *induction* by signaling . Positive_regulation NEDD9 WNT4 21317929 2437781 Chromatin immunoprecipitation ( ChIP ) assays and promoter analyses revealed three functional T-cell factor (TCF) binding sites in the promoter of HEF1 responsible for [HEF1] *induction* by signaling . Positive_regulation NEDD9 WNT6 21317929 2437782 Chromatin immunoprecipitation ( ChIP ) assays and promoter analyses revealed three functional T-cell factor (TCF) binding sites in the promoter of HEF1 responsible for [HEF1] *induction* by signaling . Positive_regulation NEFL CAPN8 9804282 544242 Only and m-calpain in vitro digestion of enriched neurofilaments *contributed* to the presence of the low MW 57 kD [NF68] break down product ( BDP ) detected in post-TBI samples . Positive_regulation NEFL IL1B 11483667 844510 Analysis of mRNA levels demonstrated elevated NF-L expression within 72 h while imaging of neurons by immunofluorescent staining for NF-L confirmed *induced* [NF-L] protein expression . Positive_regulation NEFL NFASC 25232125 2958706 Rather , high-resolution proteomic screens revealed that loss of from glial cells was *sufficient* to disrupt neuronal cytoskeletal organization and trafficking pathways , resulting in reduced levels of [neurofilament light (NF-L)] protein in distal axons and motor nerve terminals . Positive_regulation NELFCD EPHB2 23252627 2737272 Of note , RPS19 blocked up-regulation of MIF and CD74 and inactivated and NF-?B signalling , thereby *inhibiting* macrophage and T-cell infiltration , [Th1] and Th17 responses and up-regulation of pro-inflammatory cytokines ( all P < 0.01 ) . Positive_regulation NELFCD FAS 9341746 458752 CD40 ligand (CD40L) has been shown to increase surface Fas expression and induce B cell sensitivity to *dependent* CD4+ [Th1 cell mediated cytotoxicity (Th1-CMC)] . Positive_regulation NELFCD HES2 20876311 2337307 induced IL-17 in the presence of IL-6 but did not *promote* [Th1] or Th2 development under any conditions . Positive_regulation NELFCD ITGB2 20190141 2229251 In vitro , BMS-587101 inhibited *mediated* adhesion of T cells to endothelial cells , T cell proliferation , and [Th1] cytokine production . Positive_regulation NELFCD LBP 19265128 2045470 developed enhanced Th1 response , and LBP treated DCs *enhanced* [Th1] and Th2 responses in vitro and in vivo . Positive_regulation NELFCD SELL 20182448 2248644 We attempted to determine the *role* of and ICAM-1 in [Th1-] and Th2-type CHS induced by DNFB or FITC in mice lacking either L-selectin , ICAM-1 , or both . Positive_regulation NELFCD STAT4 10706670 673212 Thus , although the IL-12R beta 2 and IL-12 dependent activation are *required* for [Th1] responses , activation of this pathway is not sufficient to restore a Th1 phenotype in developing or committed Th2 cells . Positive_regulation NELFCD STAT4 15271915 1276587 A *dependent* [Th1] response is required for resistance to the helminth parasite Taenia crassiceps . Positive_regulation NELFCD STAT4 15271915 1276589 To determine the role of *dependent* [Th1] responses in the regulation of immunity to the helminth parasite Taenia crassiceps , we monitored infections with this parasite in resistant mice lacking the STAT4 gene . Positive_regulation NELFCD STAT4 17339437 1707714 The transcription factor mediates signals of various proinflammatory cytokines , such as IL-12 , IL-15 , and IL-23 , that initiate and *stabilize* [Th1] cytokine production . Positive_regulation NELFCD STAT4 23650614 2795931 As may *promote* [Th1] and Th17 development , yet antagonize Th2 development , we investigated its role in Pneumocystis murina host defense . Positive_regulation NELFCD STAT4 23772023 2807566 Opposing *roles* of and Dnmt3a in [Th1] gene regulation . Positive_regulation NELFCD TCN1 11751965 898613 We show here that CD8 T cell subsets break these rules as both and Tc2 cells *promote* [Th1] over Th2 immunity . Positive_regulation NELFCD TCN1 12538724 1050279 Thus , in contrast to CT , CTB appears to behave very differently when given by the transcutaneous as opposed to a mucosal route and the results suggest that the adjuvanticity of CT on [Th1-] and Th2 dependent responses *induced* by involves two distinct moieties , the B and the A subunits , respectively . Positive_regulation NELFCD TLR7 12515817 1039191 Polarized [Th1] responses resulting from high antigen dose were not additionally enhanced by *stimulation* of DCs by ligands . Positive_regulation NELFCD TLR7 17576775 1767950 However , *dependent* [Th1] responses occur in the absence of IL-12 . Positive_regulation NELFCD TLR7 21387177 2438231 While physiological levels of interferon-? promote vascular remodeling at the feto-maternal interface , an overshooting [Th1] cytokine response *requires* a mediated `` danger signal '' such as lipopolysaccharide (LPS) . Positive_regulation NELFCD TLR7 21624504 2481052 stimulation by microorganism derived molecules *activates* antigen presenting cells , control [T helper (Th) 1] , Th2 , and Th17 immune cell differentiation , cytokine production by mast cells , and activation of eosinophils . Positive_regulation NELFCD TLR7 23030671 2702559 The results suggest that both ligands *induce* a mixed [T(H)1-] and T ( H ) 2-like response , as characterized by the upregulation of both the T(H)1 associated cytokine interferon-? and the T(H)1 inducing cytokine interleukin (IL)-12 , in addition to the T ( H ) 2-associated cytokine IL-4 , and in the case of flagellin , IL-13 as well . Positive_regulation NELFCD TLR7 23220043 2741057 These changes may contribute to the observed induction of a T helper 2 ( Th2 ) response and the suppression of *induced* [Th1] and Th17 responses by human DCs primed with T. suis SPs . Positive_regulation NELFCD TLR7 23238878 2752148 ligands of ryegrass pollen microbial contaminants *enhance* [Th1] and Th2 responses and decrease induction of Foxp3 ( hi ) regulatory T cells . Positive_regulation NELFCD TNF 11268424 764530 Interleukin-12 and *promote* [T-helper (Th) 1] responses and cellular immunity , whereas IL-10 suppresses Th1 activities and stimulates Th2 and humoral immune responses . Positive_regulation NELFCD TNF 11454638 837700 Impaired [Th1] cytokine production in spondyloarthropathy is *restored* by . Positive_regulation NELFCD TNF 12193693 981412 The CD4 ( - ) DC produced large amounts of the proinflammatory cytokines IL-12 and TNF-alpha and *induced* [Th1] responses in allogeneic CD4 ( + ) T cells , whereas the CD4 ( + ) DC produced low amounts of IL-12 and no , but induced Th1 and Th2 responses . Positive_regulation NELFCD TNF 16799336 1579264 Subcutaneously injected *induce* an unpolarized [T(H)1/T] ( H ) 2 response and are not protective in the experimental autoimmune encephalomyelitis model . Positive_regulation NELFCD TNF 17944748 1814246 The *role* of in Trichuris muris infection II : global enhancement of ongoing [Th1] or Th2 responses . Positive_regulation NELFCD TNF 18936235 1982142 These findings indicate that at least one of the ways in which *regulates* [Th1/Th17] responses in arthritis is by down regulating the expression of p40 . Positive_regulation NELFCD TNF 18936235 1982144 Finally , although blockade *increased* numbers of [Th1] and Th17 cells in LN , it inhibited their accumulation in the joint , thereby providing an explanation for the paradox that anti-TNF therapy ameliorates arthritis despite increasing numbers of pathogenic T cells . Positive_regulation NELFCD TNF 19668260 2157878 As IFN-gamma , and IL-6 *promote* the [Th1] versus Th2 phenotype and improve T helper proliferation responses and antigen-specific CTL responses ADA may be considered a promising candidate for therapeutic vaccine adjuvant . Positive_regulation NELFCD TNF 24307739 2894814 Furthermore , using a TNFR1 ( -/- ) mouse , we demonstrate that signaling is *critical* for CDG induced Ag-specific Ab and [Th1/Th2] cytokine production . Positive_regulation NELFCD TNF 8912881 395499 Anti-IFN-gamma antibody ( Ab ) did not block the IGIF induced cytotoxicity of Th1 cells , nor did IFN-alpha , IFN-gamma , or *augment* the cytotoxic activity of [Th1] , thus indicating that this enhanced cytotoxicity of Th1 cells was mediated by IGIF . Positive_regulation NELFCD TNF 9916686 587476 Based on previous work that suggests that the production of IL-12 by activated human central nervous system derived microglia is regulated by autocrine TNF-alpha , we wanted to determine whether inhibition of could *induce* a reduction of [Th1] responses by its impact on systemic APCs . Positive_regulation NES AAAS 9371762 466120 A functional [NES] is *required* for active export , presumably by interacting directly or indirectly with the . Positive_regulation NES BMP2 23562654 2783003 While high-content-analysis demonstrated that HDACi did not significantly induce caspase-3 or p21 activity , p53-expression was increased by VPA ( 3 mM , 5 mM ) at 48 h. HDACi-exposure *induced* mineralization per cell dose-dependently to a plateau level ( VPA-0.125 mM and TSA-25 nM ) with accompanying increases in mineralization/dentinogenic associated gene expression at 5 days ( DMP-1 , , [Nestin] ) and 10 days ( DSPP , BMP-2/-4 ) . Positive_regulation NES BMP4 23562654 2783004 While high-content-analysis demonstrated that HDACi did not significantly induce caspase-3 or p21 activity , p53-expression was increased by VPA ( 3 mM , 5 mM ) at 48 h. HDACi-exposure *induced* mineralization per cell dose-dependently to a plateau level ( VPA-0.125 mM and TSA-25 nM ) with accompanying increases in mineralization/dentinogenic associated gene expression at 5 days ( DMP-1 , , [Nestin] ) and 10 days ( DSPP , BMP-2/-4 ) . Positive_regulation NES CASP3 19409199 2082470 NPCs under OGD conditions exhibited reduction of Akt phosphorylation , decrease of the Bcl-2/Bax ratio , *activation* of , cleavage of PARP , and downregulation of beta-catenin and [nestin] . Positive_regulation NES CDK5 23000950 2780256 Roscovitine , a inhibitor , *reduced* the degradation of [nestin] . Positive_regulation NES CDKN1A 17477906 1738598 Altogether , these results demonstrate that reactive oxygen species *induce* ( Cip1 ) degradation through an [NES-] , Skp2- , and ubiquitin dependent pathway . Positive_regulation NES CISH 19147497 2043009 The for Sox and POU family transcription factors and the hormone-responsive element are *essential* for [nestin] expression during embryonic carcinoma P19 cell neural differentiation and in the developing chick neural tube . Positive_regulation NES CLTA 22400223 2521126 The uptake mechanism results demonstrated that the internalization of [CTAB-NES] and NES *involved* and caveolae mediated endocytosis while macropinocytosis only influenced the uptake of CTAB-NES in MCF-7 cells for CTAB could mediate adsorptive pinocytosis . Positive_regulation NES CLTC 22400223 2521127 The uptake mechanism results demonstrated that the internalization of CTAB-NES and [NES] *involved* and caveolae mediated endocytosis while macropinocytosis only influenced the uptake of CTAB-NES in MCF-7 cells for CTAB could mediate adsorptive pinocytosis . Positive_regulation NES EGF 24462842 2918282 *increases* the expression of [Nestin] in rat reactive astrocytes through the Ras-Raf-ERK pathway . Positive_regulation NES EGF 24462842 2918283 Furthermore , as shown by immunoblot analyses , *regulated* [Nestin] expression through EGFR activation . Positive_regulation NES EGFR 19245830 2050740 In this study , we showed that [nestin] expression is *regulated* by the thrombin mediated transactivation in serum deprived primary cultures of rat vascular smooth muscle cells ( VSMCs ) . Positive_regulation NES EIF5A 11238447 790659 In vitro binding studies demonstrate that is *required* for efficient interaction of [Rev-NES] with CRM1/exportin1 and that eIF-5A interacts with the nucleoporins CAN/nup214 , nup153 , nup98 , and nup62 . Positive_regulation NES FGF2 10753656 681773 These quiescent cells , located in the pigmented ciliary bodies , proliferate in the *presence* of and express the neuroectodermal marker [nestin] . Positive_regulation NES FGF2 16859812 1746959 Here we show that elevated *enhances* the division and [nestin] levels of cultured adult rat hippocampal progenitors but impairs neuronal lineage determination and maturation of these cells in culture . Positive_regulation NES FGF2 17697621 1782268 ( 3 ) Exogenous could *enhance* the expression of [nestin] and GAP-43 in the brain of neonatal rats with HIBD , which may play an important role in restoration of neurons damaged due to hypoxia-ischemia . Positive_regulation NES FGF2 23271288 2709689 The results showed that *increased* the expression of [Nestin] , dramatically inhibited the expression of GFAP and Tuj1 and slightly suppressed the expression of CNPase . Positive_regulation NES FGF2 23430693 2755806 Neutralization studies showed that MSC derived was a major and diffusible *inducer* of rat [nestin] , whereas MSC derived bone morphogenetic proteins ( BMPs ) , particularly , BMP4 , were astrogenesis mediators , predominantly acting in a coculture setting . Positive_regulation NES FGF2 23611784 2790278 Our RT-PCR results showed that C6 glioma cells express FGFR1/3 , and FGFRs is required for *induced* [nestin] expression . Positive_regulation NES FGF2 23611784 2790279 Further signaling analysis also revealed that *induced* [nestin] expression is mediated through FGFR-MAPK-ERK signaling axis and the transcriptional factor Sp1 . Positive_regulation NES FGF2 24855512 2010090 [Nestin] expression and spheroid forming capacity were both *blocked* by removal of from the induction medium . Positive_regulation NES FGF2 24855512 2010091 The *induced* , [nestin] expressing spheroids possessed most of the features distinctive of skin derived precursor cells . Positive_regulation NES FOSB 15861185 1425998 The adenovirus mediated expression of or DeltaFosB *induced* expression of [nestin] , glial fibrillary acidic protein and galectin-1 in rat embryonic cortical cells . Positive_regulation NES GCG 17366624 1727468 Furthermore , our results suggest that [nestin] expression is *regulated* by signaling . Positive_regulation NES GFAP 17571302 1753788 Furthermore , [nestin] was *detected* in precursor cells , beta-tubulin III and were detected in the generated precursor neurocytes immunocytochemically . Positive_regulation NES GFAP 20151365 2214743 [Nestin] was upregulated by 3 DPI and declined between 7 and 49 DPI in all regions , and *increased* and remained above naïve levels at all timepoints . Positive_regulation NES HBEGF 24188029 2921118 changed morphology of 2D and Bioactive3D cultured astrocytes toward a radial glia-like phenotype and *induced* the expression of intermediate filament and progenitor cell marker protein [nestin] . Positive_regulation NES IL1B 19940926 2167649 Importantly , [Nestin-Cre] and GFAP-Cre rank ( floxed ) deleter mice are resistant to lipopolysaccharide induced fever as well as fever in *response* to the key inflammatory cytokines and TNFalpha . Positive_regulation NES MNAT1 12832492 1105741 Ectopic expression of cdk5 and in central nervous system progenitor cells and in myogenic precursor cells *induced* elevated phosphorylation and reorganization of [nestin] . Positive_regulation NES MSC 17288545 1710938 In conclusion , using a novel protocol we demonstrate that adult BM-and neonatal PL-derived can be *induced* to express high levels of FZD-9 , Oct-4 , nanog-3 , and [nestin] and are able of multi-lineage differentiation . Positive_regulation NES MSN 22889732 2647132 Strikingly , Cln2 export depends on a *dependent* [NES] between amino acids 225 and 299 . Positive_regulation NES MYCN 15117961 1258520 Neuroblastic cell variants with high levels of N-Myc protein have significantly higher nestin protein levels than non amplified cell lines , suggesting that the transcription factor may *regulate* [nestin] expression . Positive_regulation NES NCBP1 23941747 2855632 Based on a previous report , we studied the potential involvement of the adenosine A1 receptor in the effect of CBC on these cells and found that the selective adenosine A1 receptor antagonist , DPCPX , counteracted both ERK1/2 phosphorylation and *up-regulation* of [nestin] by , indicating that also adenosine is involved in these effects of CBC , but possibly not in CBC inhibitory effect on GFAP expression . Positive_regulation NES NCBP2 23941747 2855633 Based on a previous report , we studied the potential involvement of the adenosine A1 receptor in the effect of CBC on these cells and found that the selective adenosine A1 receptor antagonist , DPCPX , counteracted both ERK1/2 phosphorylation and *up-regulation* of [nestin] by , indicating that also adenosine is involved in these effects of CBC , but possibly not in CBC inhibitory effect on GFAP expression . Positive_regulation NES NOTCH1 17217625 1664098 signaling *enhances* [nestin] expression in gliomas . Positive_regulation NES NOTCH1 17217625 1664102 In culture , activity *activates* the [nestin] promoter . Positive_regulation NES NOTCH2 17217625 1664099 signaling *enhances* [nestin] expression in gliomas . Positive_regulation NES NOTCH2 17217625 1664103 In culture , activity *activates* the [nestin] promoter . Positive_regulation NES NOTCH3 17217625 1664100 signaling *enhances* [nestin] expression in gliomas . Positive_regulation NES NOTCH3 17217625 1664104 In culture , activity *activates* the [nestin] promoter . Positive_regulation NES NOTCH4 17217625 1664101 signaling *enhances* [nestin] expression in gliomas . Positive_regulation NES NOTCH4 17217625 1664105 In culture , activity *activates* the [nestin] promoter . Positive_regulation NES NPS 24467380 2907886 significantly *increase* expression of genes involved in cell proliferation ( reelin , [nestin] , and Pax6 ) and neuronal differentiation ( neurogenin , neuroD1 , neuregulin , neuroligin , and Stat3 ) . Positive_regulation NES NUP153 9371762 466130 A functional [NES] is *required* for active export , presumably by interacting directly or indirectly with the . Positive_regulation NES NUP155 9371762 466131 A functional [NES] is *required* for active export , presumably by interacting directly or indirectly with the . Positive_regulation NES NUP188 9371762 466122 A functional [NES] is *required* for active export , presumably by interacting directly or indirectly with the . Positive_regulation NES NUP205 9371762 466123 A functional [NES] is *required* for active export , presumably by interacting directly or indirectly with the . Positive_regulation NES NUP210 9371762 466128 A functional [NES] is *required* for active export , presumably by interacting directly or indirectly with the . Positive_regulation NES NUP214 9371762 466132 A functional [NES] is *required* for active export , presumably by interacting directly or indirectly with the . Positive_regulation NES NUP35 9371762 466127 A functional [NES] is *required* for active export , presumably by interacting directly or indirectly with the . Positive_regulation NES NUP43 9371762 466125 A functional [NES] is *required* for active export , presumably by interacting directly or indirectly with the . Positive_regulation NES NUP50 9371762 466133 A functional [NES] is *required* for active export , presumably by interacting directly or indirectly with the . Positive_regulation NES NUP85 9371762 466136 A functional [NES] is *required* for active export , presumably by interacting directly or indirectly with the . Positive_regulation NES NUP88 9371762 466134 A functional [NES] is *required* for active export , presumably by interacting directly or indirectly with the . Positive_regulation NES NUP93 9371762 466126 A functional [NES] is *required* for active export , presumably by interacting directly or indirectly with the . Positive_regulation NES NUP98 9371762 466135 A functional [NES] is *required* for active export , presumably by interacting directly or indirectly with the . Positive_regulation NES NUPL2 9371762 466121 A functional [NES] is *required* for active export , presumably by interacting directly or indirectly with the . Positive_regulation NES PDGFB 19896481 2217086 Among major serum growth factors and cytokines , was the most potent *inducer* of [nestin] expression . Positive_regulation NES POM121 9371762 466124 A functional [NES] is *required* for active export , presumably by interacting directly or indirectly with the . Positive_regulation NES POU3F2 18923447 2047080 SOX9 and SOX10 but not are *required* for [nestin] expression in human melanoma cells . Positive_regulation NES RAE1 9371762 466137 A functional [NES] is *required* for active export , presumably by interacting directly or indirectly with the . Positive_regulation NES RAN 15020682 1221562 CRM1 and are present but a [NES-CRM1-RanGTP] complex is not *required* in Balbiani ring mRNP particles from the gene to the cytoplasm . Positive_regulation NES RANBP2 9371762 466138 A functional [NES] is *required* for active export , presumably by interacting directly or indirectly with the . Positive_regulation NES SEH1L 9371762 466129 A functional [NES] is *required* for active export , presumably by interacting directly or indirectly with the . Positive_regulation NES SF1 19147497 2043013 Sox2 and may *mediate* basal [nestin] expression in undifferentiated P19EC cells , whereas Sox2 , Brn1 , and Brn2 bind to the enhancer in P19 neural progenitor cells . Positive_regulation NES SOX10 18923447 2047079 SOX9 and but not BRN2 are *required* for [nestin] expression in human melanoma cells . Positive_regulation NES SOX11 20951776 2369292 In the injured spinal cord , expression of the neural stem cell associated gene [Nestin] , and the proneural gene Ascl1a ( Mash1a ) , which are involved in the self-renewal and cell fate specification of endogenous neural stem cells , respectively , is *regulated* by . Positive_regulation NES SP1 19245830 2050743 In addition , the EMSA experiment showed that the transcriptional factor is *critical* for the thrombin induced [nestin] expression in rat VSMCs . Positive_regulation NES TGFB1 18005096 1971421 Alpha-smooth muscle actin ( alpha-SMA ) and [nestin] expression in reactive astrocytes in multiple sclerosis lesions : potential regulatory *role* of ( TGF-beta1 ) . Positive_regulation NES TGFB2 17449229 1743023 Significantly , exogenous *induced* [nestin] and Dspp expression in dental pulp cells in the developing tooth organ . Positive_regulation NES TP53 16007197 1459375 We show that efficiently drives the relocation of the chimeric reporter in response to irradiation and that this process *requires* the C-terminal [nuclear export signal (NES)] . Positive_regulation NES TP53 17371868 1734679 The cytoplasmic localization of mutant *required* the C-terminal [NES] and an intact ubiquitination pathway . Positive_regulation NES TP53 23562654 2783005 While high-content-analysis demonstrated that HDACi did not significantly induce caspase-3 or p21 activity , was increased by VPA ( 3 mM , 5 mM ) at 48 h. HDACi-exposure *induced* mineralization per cell dose-dependently to a plateau level ( VPA-0.125 mM and TSA-25 nM ) with accompanying increases in mineralization/dentinogenic associated gene expression at 5 days ( DMP-1 , BMP-2/-4 , [Nestin] ) and 10 days ( DSPP , BMP-2/-4 ) . Positive_regulation NES TPR 9371762 466119 A functional [NES] is *required* for active export , presumably by interacting directly or indirectly with the . Positive_regulation NES USO1 21060813 2344795 In addition to the revised map of NLS , our results suggest that HBc could shuttle rapidly between nucleus and cytoplasm via a novel *dependent* [NES] . Positive_regulation NES VIM 17573051 1767860 By 28 days post-lesion , while persisted in reactive astrocytes in SON and PVN , [nestin-IR] could hardly be *detected* . Positive_regulation NES VIM 25028355 2953234 [Nestin] was *detected* in a large proportion of muscle fibers in the orbital layer and to some extent also in the global layer , whereas no muscle fibers contained . Positive_regulation NES VIM 9645943 514920 A wild-type rat nestin gene transfected into the IF-free SW13 cell line failed to assemble into a filamentous network but was incorporated into the existing IF network of a subclone expressing vimentin , demonstrating that [nestin] *requires* for proper assembly . Positive_regulation NES WT1 16614054 1589530 Intermediate filament protein [nestin] is expressed in developing kidney and heart and might be *regulated* by the Wilms' tumor suppressor . Positive_regulation NES WT1 18212735 1918978 We showed that the Wilms ' tumour suppressor *activates* [nestin] during development . Positive_regulation NES XPO1 10581242 570226 This shuttling requires a previously unidentified *dependent* [nuclear export signal (NES)] located within the N-terminal domain of IkappaBalpha at amino acids 45-55 . Positive_regulation NES XPO1 11115515 802269 Leptomycin B treatment induced rapid nuclear accumulation of GFP-lambda as well as endogenous lambdaPKC suggesting the existence of a *dependent* [nuclear export signal (NES)] . Positive_regulation NES XPO1 12438613 1016829 Thus , this region is required for efficient ICP27 export but does not function as a *dependent* [NES] . Positive_regulation NES XPO1 12773398 1094957 Human NMD3 (hNMD3) contains a *dependent* leucine-rich [nuclear export signal (NES)] and a complex , dispersed nuclear localization signal ( NLS ) , the basic region of which is also required for nucleolar accumulation . Positive_regulation NES XPO1 12805458 1101635 We recently characterized Vpr as a nucleocytoplasmic shuttling protein that contains two novel nuclear import signals and an *dependent* [nuclear export signal (NES)] . Positive_regulation NES XPO1 14617633 1200697 We identified a novel *dependent* [nuclear export signal (NES)] comprising 13 amino acids ( KKVVKQASEGPLK ) in the C-terminal domain of GAPDH , truncation or mutation of which abrogated CRM1 binding and caused nuclear accumulation of GAPDH . Positive_regulation NES XPO1 14638854 1171553 Nuclear import of an nuclear localization signal enhanced green fluorescent protein ( NLS-EGFP ) reporter is not affected in DNup88 ( members only ; mbo ) mutants , whereas the level of *dependent* EGFP-nuclear export signal ( [EGFP-NES] ) export is increased . Positive_regulation NES XPO1 14647430 1218708 We identified a functional *dependent* [nuclear export sequence (NES)] near the N-terminal RING domain of BARD1 . Positive_regulation NES XPO1 15020682 1221561 and Ran are present but a [NES-CRM1-RanGTP] complex is not *required* in Balbiani ring mRNP particles from the gene to the cytoplasm . Positive_regulation NES XPO1 15113915 1241382 Analysis of the Nipah virus V protein has revealed a region between amino acids 174 and 192 that functions as a *dependent* [nuclear export signal (NES)] . Positive_regulation NES XPO1 15208320 1289033 In addition , we have characterized two novel leucine-rich nuclear export signals ( NESs ) that are responsible for the nuclear export of RIP3 to the cytoplasm via a *dependent* pathway and an extra leucine-rich [NES] in the N terminus of RIP3 that contributes to the cytoplasmic distribution in a CRM1 independent manner . Positive_regulation NES XPO1 15265700 1275439 We have identified a new *dependent* leucine-rich [nuclear export signal (NES)] in the linker region between cIAP1 BIR2 and BIR3 repeats . Positive_regulation NES XPO1 15780878 1385367 In the presence of Leptomycin B , P is retained in the nucleus indicating that it contains a *dependent* [nuclear export signal (NES)] . Positive_regulation NES XPO1 16093348 1460720 We also identify a *dependent* [nuclear export signal (NES)] adjacent to the Mcm3 NLS . Positive_regulation NES XPO1 16483627 1567645 Mutations on the leucine-rich region of BRO proteins resulted in nuclear accumulation of transiently expressed proteins , suggesting that this region functions as a *dependent* [nuclear export signal (NES)] . Positive_regulation NES XPO1 16501600 1581842 Alignment of the C-terminus of the various NPM mutants revealed the obligatory presence of four amino-acid residues that match a *dependent* [nuclear export signal (NES)] . Positive_regulation NES XPO1 16738331 1566336 Here we identify a bipartite nuclear localization signal ( NLS ) and a *dependent* [nuclear export signal (NES)] in the SUMO protease SENP2 . Positive_regulation NES XPO1 16782704 1599372 However , under isotonic conditions , nuclear export of OREBP/TonEBP is mediated by a *dependent* , leucine-rich canonical [nuclear export sequence (NES)] located in the N terminus . Positive_regulation NES XPO1 16785531 1577108 A *dependent* [nuclear export signal (NES)] at the AID C terminus is necessary for CSR , and has been suggested to associate with CSR-specific cofactors . Positive_regulation NES XPO1 16984408 1633664 We show that the dynamic intracellular localization of survivin ( 140 ) is mediated by a *dependent* [nuclear export signal (NES)] present also in survivin ( 121 ) , but absent in survivin ( 40 ) . Positive_regulation NES XPO1 17065226 1649632 We first reported a *dependent* [nuclear export signal (NES)] in E1A that is conserved in the group C adenoviruses . Positive_regulation NES XPO1 17099069 1676208 We identified an evolutionary conserved *dependent* [nuclear export signal (NES)] in survivin . Positive_regulation NES XPO1 17099693 1650811 Here , we show that the nuclear export receptor is crucially *involved* in tethering the CPC to the centromere by interacting with a leucine-rich [nuclear export signal (NES)] , evolutionarily conserved in all mammalian Survivin proteins . Positive_regulation NES XPO1 17185387 1688394 Additionally , we identify a cryptic *dependent* [nuclear export signal (NES)] within ZIC3 , and identify a mutation within this region in a patient with heterotaxy . Positive_regulation NES XPO1 17303464 1705073 The Rev ( 1.4 ) -EGFP nuclear export assay showed that this putative NES has a *dependent* [NES] activity . Positive_regulation NES XPO1 17314103 1719545 In this study we have defined a nuclear retention signal ( NRS ) in the hinge region of GR that actively opposes the nuclear export of GR as well as the nuclear export mediated through an ectopic *dependent* [nuclear export signal (NES)] . Positive_regulation NES XPO1 17428914 1728839 Functional inactivation of the E1B-55K *dependent* [nuclear export signal (NES)] or leptomycin B treatment causes an almost complete redistribution of the viral protein from the cytoplasm to the nucleus and its accumulation at the periphery of the viral replication centers . Positive_regulation NES XPO1 17488649 1750646 A *dependent* leucine-rich [NES] , which is sensitive to an inhibitory effect of leptomycin B , was found in the cytoplasmic retention region previously identified within the ligand binding domain of rat CAR ( residues 220-258 ) . Positive_regulation NES XPO1 17582222 1764174 We here show that the intracellular localization of these splice variants depends on a *dependent* [nuclear export signal (NES)] present in survivin , surviving ( -2B ) and survivin ( -3B ) , but absent in survivin ( -deltaEx3 ) and survivin ( -2alpha ) . Positive_regulation NES XPO1 19144820 2037887 Surprisingly , fusions of Mex67 , the tRNA exportin Los1 , Mtr2 , Cse1 , or Msn5 to Nmd3 , lacking its *dependent* [nuclear export signal (NES)] , all functioned in export . Positive_regulation NES XPO1 20185565 2272447 We demonstrate that hMSH5 possesses a *dependent* [nuclear export signal (NES)] and a nuclear localization signal that participates to its nuclear targeting . Positive_regulation NES XPO1 20685962 2322831 We identify highly conserved carboxy-terminal hydrophobic amino acids that function as a leptomycin B-sensitive , *dependent* [nuclear export sequence (NES)] in the AMPK catalytic subunit ( AMPKa ) . Positive_regulation NES XPO1 22623727 2686820 Here , we characterize the active nuclear export of cofilin through a leptomycin-B-sensitive , *dependent* , [nuclear export signal (NES)] . Positive_regulation NES XPO1 23948433 2845349 Here we report that JMJD5 contains a functional bipartite nuclear localization signal ( NLS ) and a *dependent* [nuclear export signal (NES)] . Positive_regulation NEU1 TLR7 21873432 2491467 Recently , we reported a novel membrane sialidase controlling mechanism that depends on ligand binding to its to *induce* mammalian [neuraminidase-1 (Neu1)] activity , to influence receptor desialylation , and subsequently to induce TLR receptor activation and the production of nitric oxide and proinflammatory cytokines in dendritic and macrophage cells . Positive_regulation NEU1 TNF 12867430 1141904 Studies conducted to understand the role of MAPKs in the induction of sialidase activity revealed that LPS induced [sialidase] activity was *dependent* on p42/44 MAPK mediated production . Positive_regulation NEU1 TNF 12867430 1142040 Subsequently , mediated p38 MAPK activation *induced* [sialidase] activity and CD44-HA binding . Positive_regulation NEU2 TNF 12867430 1141907 Studies conducted to understand the role of MAPKs in the induction of sialidase activity revealed that LPS induced [sialidase] activity was *dependent* on p42/44 MAPK mediated production . Positive_regulation NEU2 TNF 12867430 1142055 Subsequently , mediated p38 MAPK activation *induced* [sialidase] activity and CD44-HA binding . Positive_regulation NEU3 TNF 12867430 1141910 Studies conducted to understand the role of MAPKs in the induction of sialidase activity revealed that LPS induced [sialidase] activity was *dependent* on p42/44 MAPK mediated production . Positive_regulation NEU3 TNF 12867430 1142070 Subsequently , mediated p38 MAPK activation *induced* [sialidase] activity and CD44-HA binding . Positive_regulation NEU4 TNF 12867430 1141901 Studies conducted to understand the role of MAPKs in the induction of sialidase activity revealed that LPS induced [sialidase] activity was *dependent* on p42/44 MAPK mediated production . Positive_regulation NEU4 TNF 12867430 1141941 Subsequently , mediated p38 MAPK activation *induced* [sialidase] activity and CD44-HA binding . Positive_regulation NEUROD1 ADRB2 9675299 520338 It was also observed that the elevated expression of the in the neuronal NT2 cells *resulted* in an enhanced level of [neuronal differentiation] compared to the wild type cells . Positive_regulation NEUROD1 CABP4 11563845 862980 An MN9D dopaminergic neuronal cell line overexpressing calbindin-D28K ( MN9D/Calbindin ) was established in order to investigate directly the potential *role* of in [neuronal differentiation] . Positive_regulation NEUROD1 EPHB2 10617116 656436 Thus , activation of may not be *essential* for [neuronal differentiation] in F11 cells and alphao may cause changes in NOG by inhibiting CREB activation . Positive_regulation NEUROD1 EPHB2 10772818 686263 However , activation and nuclear accumulation of were not *sufficient* to induce [neuronal differentiation] in SH-SY5Y , as demonstrated by the response to TPA in serum-free cultures . Positive_regulation NEUROD1 EPHB2 12865141 1111809 The results demonstrate that PKA and play a key role in KCl- and forskolin *induced* [neuronal differentiation] by integration of signals from both pathways . Positive_regulation NEUROD1 EPHB2 17976838 1831194 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Positive_regulation NEUROD1 EPHB2 18171671 1869797 Basic fibroblast growth factor induced [neuronal differentiation] of mouse bone marrow stromal cells *requires* FGFR-1 , , and transcription factor AP-1 . Positive_regulation NEUROD1 EPHB2 19615362 2142778 Our findings indicate that HA *inhibits* NGF induced [neuronal differentiation] of PC12 cells partially by inhibiting phosphorylation through RHAMM , and suggest that the binding of HA to RHAMM modifies the signaling pathways in PC12 cells treated with NGF . Positive_regulation NEUROD1 EPHB2 20525991 2301543 Both PtdCho biosynthesis and [neuronal differentiation] are *dependent* on activation . Positive_regulation NEUROD1 EPHB2 23907465 2822536 PKC dependent phosphorylation is *essential* for P2X7 receptor mediated [neuronal differentiation] of neural progenitor cells . Positive_regulation NEUROD1 EPHB2 9525930 495599 Induction of [neuronal differentiation] of the rat pheochromocytoma cell line , PC12 cells , by nerve growth factor (NGF) *requires* activation of the mitogen activated protein (MAP) kinase or extracellular signal regulated kinase ( ) . Positive_regulation NEUROD1 F2R 19686683 2126368 The phosphorylation of Mib by *results* in Mib degradation , repression of Notch signaling , and stimulation of [neuronal differentiation] . Positive_regulation NEUROD1 GPR115 12473665 1055764 Accordingly , we reported here that pituitary adenylate cyclase activating polypeptide ( PACAP ) , whose *triggers* [neuronal differentiation] of the PC12 cell line via ERK1/2 activation , transiently activated Ras and induced the sustained GTP loading of Rap1 . Positive_regulation NEUROD1 GPR132 12473665 1055753 Accordingly , we reported here that pituitary adenylate cyclase activating polypeptide ( PACAP ) , whose *triggers* [neuronal differentiation] of the PC12 cell line via ERK1/2 activation , transiently activated Ras and induced the sustained GTP loading of Rap1 . Positive_regulation NEUROD1 GPR87 12473665 1055833 Accordingly , we reported here that pituitary adenylate cyclase activating polypeptide ( PACAP ) , whose *triggers* [neuronal differentiation] of the PC12 cell line via ERK1/2 activation , transiently activated Ras and induced the sustained GTP loading of Rap1 . Positive_regulation NEUROD1 IFI27 10837916 699515 Expression and *role* of ( kip1 ) in [neuronal differentiation] of embryonal carcinoma cells . Positive_regulation NEUROD1 MAP2K6 17976838 1831200 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Positive_regulation NEUROD1 MSX1 18385323 1893092 In contrast , few Lmx1a transduced cells matured into neurons , and overexpression *promoted* oligodendrogenesis rather than [neuronal differentiation] . Positive_regulation NEUROD1 S100B 23649988 2800699 enhanced significantly the early progenitor cell proliferation in the SGZ as well as cell survival and migration to the GCL , and *promoted* [neuronal differentiation] . Positive_regulation NEUROD1 S100B 9191095 437650 *promotes* [neuronal differentiation] and survival but may be detrimental to cells if overexpressed . Positive_regulation NEUROD1 TGM2 11166134 782919 Considering these and other previous findings , this study was carried out to determine whether is *involved* in [neuronal differentiation] of SH-SY5Y cells . Positive_regulation NEUROD1 TGM2 11166134 782927 These data indicate that is *necessary* and sufficient for [neuronal differentiation] of human neuroblastoma SH-SY5Y cells . Positive_regulation NEUROD1 TLR7 23843519 2816461 These results all suggest that negatively *regulates* [neuronal differentiation] . Positive_regulation NEUROD1 TMOD1 23638401 2779390 Our data demonstrate that is *involved* in [neuronal differentiation] for proper neurite formation and outgrowth , and that Tmod2 inhibits these processes . Positive_regulation NEUROD1 TNF 7690970 228700 Rat PC12 pheochromocytoma cells transiently transfected with TNF-p140trk chimeras , which contain the extracellular domain of TNF receptor and the transmembrane and cytoplasmic domains of p140trk , showed *dependent* [neuronal differentiation] and cell survival . Positive_regulation NEUROD1 WNT7A 19545542 2109887 Long-term activation of Wnt pathway by or by treatment with GSK3 inhibitors *promoted* a moderate increase of the [neuronal differentiation] and blocked gliogenesis . Positive_regulation NEUROD1 WNT7A 23629626 2795633 stimulated neural stem cell proliferation by activating the ß-catenin-cyclin D1 pathway and *promoted* [neuronal differentiation] and maturation by inducing the ß-catenin-neurogenin 2 pathway . Positive_regulation NEUROD2 ADRB2 9675299 520339 It was also observed that the elevated expression of the in the neuronal NT2 cells *resulted* in an enhanced level of [neuronal differentiation] compared to the wild type cells . Positive_regulation NEUROD2 CABP4 11563845 862985 An MN9D dopaminergic neuronal cell line overexpressing calbindin-D28K ( MN9D/Calbindin ) was established in order to investigate directly the potential *role* of in [neuronal differentiation] . Positive_regulation NEUROD2 EPHB2 10617116 656437 Thus , activation of may not be *essential* for [neuronal differentiation] in F11 cells and alphao may cause changes in NOG by inhibiting CREB activation . Positive_regulation NEUROD2 EPHB2 10772818 686264 However , activation and nuclear accumulation of were not *sufficient* to induce [neuronal differentiation] in SH-SY5Y , as demonstrated by the response to TPA in serum-free cultures . Positive_regulation NEUROD2 EPHB2 12865141 1111816 The results demonstrate that PKA and play a key role in KCl- and forskolin *induced* [neuronal differentiation] by integration of signals from both pathways . Positive_regulation NEUROD2 EPHB2 17976838 1831202 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Positive_regulation NEUROD2 EPHB2 18171671 1869814 Basic fibroblast growth factor induced [neuronal differentiation] of mouse bone marrow stromal cells *requires* FGFR-1 , , and transcription factor AP-1 . Positive_regulation NEUROD2 EPHB2 19615362 2142780 Our findings indicate that HA *inhibits* NGF induced [neuronal differentiation] of PC12 cells partially by inhibiting phosphorylation through RHAMM , and suggest that the binding of HA to RHAMM modifies the signaling pathways in PC12 cells treated with NGF . Positive_regulation NEUROD2 EPHB2 20525991 2301544 Both PtdCho biosynthesis and [neuronal differentiation] are *dependent* on activation . Positive_regulation NEUROD2 EPHB2 23907465 2822537 PKC dependent phosphorylation is *essential* for P2X7 receptor mediated [neuronal differentiation] of neural progenitor cells . Positive_regulation NEUROD2 EPHB2 9525930 495614 Induction of [neuronal differentiation] of the rat pheochromocytoma cell line , PC12 cells , by nerve growth factor (NGF) *requires* activation of the mitogen activated protein (MAP) kinase or extracellular signal regulated kinase ( ) . Positive_regulation NEUROD2 F2R 19686683 2126369 The phosphorylation of Mib by *results* in Mib degradation , repression of Notch signaling , and stimulation of [neuronal differentiation] . Positive_regulation NEUROD2 GPR115 12473665 1055857 Accordingly , we reported here that pituitary adenylate cyclase activating polypeptide ( PACAP ) , whose *triggers* [neuronal differentiation] of the PC12 cell line via ERK1/2 activation , transiently activated Ras and induced the sustained GTP loading of Rap1 . Positive_regulation NEUROD2 GPR132 12473665 1055846 Accordingly , we reported here that pituitary adenylate cyclase activating polypeptide ( PACAP ) , whose *triggers* [neuronal differentiation] of the PC12 cell line via ERK1/2 activation , transiently activated Ras and induced the sustained GTP loading of Rap1 . Positive_regulation NEUROD2 GPR87 12473665 1055926 Accordingly , we reported here that pituitary adenylate cyclase activating polypeptide ( PACAP ) , whose *triggers* [neuronal differentiation] of the PC12 cell line via ERK1/2 activation , transiently activated Ras and induced the sustained GTP loading of Rap1 . Positive_regulation NEUROD2 IFI27 10837916 699516 Expression and *role* of ( kip1 ) in [neuronal differentiation] of embryonal carcinoma cells . Positive_regulation NEUROD2 MAP2K6 17976838 1831208 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Positive_regulation NEUROD2 MSX1 18385323 1893093 In contrast , few Lmx1a transduced cells matured into neurons , and overexpression *promoted* oligodendrogenesis rather than [neuronal differentiation] . Positive_regulation NEUROD2 S100B 23649988 2800700 enhanced significantly the early progenitor cell proliferation in the SGZ as well as cell survival and migration to the GCL , and *promoted* [neuronal differentiation] . Positive_regulation NEUROD2 S100B 9191095 437651 *promotes* [neuronal differentiation] and survival but may be detrimental to cells if overexpressed . Positive_regulation NEUROD2 TGM2 11166134 782920 Considering these and other previous findings , this study was carried out to determine whether is *involved* in [neuronal differentiation] of SH-SY5Y cells . Positive_regulation NEUROD2 TGM2 11166134 782928 These data indicate that is *necessary* and sufficient for [neuronal differentiation] of human neuroblastoma SH-SY5Y cells . Positive_regulation NEUROD2 TLR7 23843519 2816462 These results all suggest that negatively *regulates* [neuronal differentiation] . Positive_regulation NEUROD2 TMOD1 23638401 2779391 Our data demonstrate that is *involved* in [neuronal differentiation] for proper neurite formation and outgrowth , and that Tmod2 inhibits these processes . Positive_regulation NEUROD2 TNF 7690970 228701 Rat PC12 pheochromocytoma cells transiently transfected with TNF-p140trk chimeras , which contain the extracellular domain of TNF receptor and the transmembrane and cytoplasmic domains of p140trk , showed *dependent* [neuronal differentiation] and cell survival . Positive_regulation NEUROD2 WNT7A 19545542 2109888 Long-term activation of Wnt pathway by or by treatment with GSK3 inhibitors *promoted* a moderate increase of the [neuronal differentiation] and blocked gliogenesis . Positive_regulation NEUROD2 WNT7A 23629626 2795634 stimulated neural stem cell proliferation by activating the ß-catenin-cyclin D1 pathway and *promoted* [neuronal differentiation] and maturation by inducing the ß-catenin-neurogenin 2 pathway . Positive_regulation NEUROD4 ADRB2 9675299 520336 It was also observed that the elevated expression of the in the neuronal NT2 cells *resulted* in an enhanced level of [neuronal differentiation] compared to the wild type cells . Positive_regulation NEUROD4 CABP4 11563845 862970 An MN9D dopaminergic neuronal cell line overexpressing calbindin-D28K ( MN9D/Calbindin ) was established in order to investigate directly the potential *role* of in [neuronal differentiation] . Positive_regulation NEUROD4 EPHB2 10617116 656434 Thus , activation of may not be *essential* for [neuronal differentiation] in F11 cells and alphao may cause changes in NOG by inhibiting CREB activation . Positive_regulation NEUROD4 EPHB2 10772818 686261 However , activation and nuclear accumulation of were not *sufficient* to induce [neuronal differentiation] in SH-SY5Y , as demonstrated by the response to TPA in serum-free cultures . Positive_regulation NEUROD4 EPHB2 12865141 1111795 The results demonstrate that PKA and play a key role in KCl- and forskolin *induced* [neuronal differentiation] by integration of signals from both pathways . Positive_regulation NEUROD4 EPHB2 17976838 1831178 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Positive_regulation NEUROD4 EPHB2 18171671 1869699 Basic fibroblast growth factor induced [neuronal differentiation] of mouse bone marrow stromal cells *requires* FGFR-1 , , and transcription factor AP-1 . Positive_regulation NEUROD4 EPHB2 19615362 2142774 Our findings indicate that HA *inhibits* NGF induced [neuronal differentiation] of PC12 cells partially by inhibiting phosphorylation through RHAMM , and suggest that the binding of HA to RHAMM modifies the signaling pathways in PC12 cells treated with NGF . Positive_regulation NEUROD4 EPHB2 20525991 2301541 Both PtdCho biosynthesis and [neuronal differentiation] are *dependent* on activation . Positive_regulation NEUROD4 EPHB2 23907465 2822534 PKC dependent phosphorylation is *essential* for P2X7 receptor mediated [neuronal differentiation] of neural progenitor cells . Positive_regulation NEUROD4 EPHB2 9525930 495499 Induction of [neuronal differentiation] of the rat pheochromocytoma cell line , PC12 cells , by nerve growth factor (NGF) *requires* activation of the mitogen activated protein (MAP) kinase or extracellular signal regulated kinase ( ) . Positive_regulation NEUROD4 F2R 19686683 2126365 The phosphorylation of Mib by *results* in Mib degradation , repression of Notch signaling , and stimulation of [neuronal differentiation] . Positive_regulation NEUROD4 GPR115 12473665 1055578 Accordingly , we reported here that pituitary adenylate cyclase activating polypeptide ( PACAP ) , whose *triggers* [neuronal differentiation] of the PC12 cell line via ERK1/2 activation , transiently activated Ras and induced the sustained GTP loading of Rap1 . Positive_regulation NEUROD4 GPR132 12473665 1055567 Accordingly , we reported here that pituitary adenylate cyclase activating polypeptide ( PACAP ) , whose *triggers* [neuronal differentiation] of the PC12 cell line via ERK1/2 activation , transiently activated Ras and induced the sustained GTP loading of Rap1 . Positive_regulation NEUROD4 GPR87 12473665 1055647 Accordingly , we reported here that pituitary adenylate cyclase activating polypeptide ( PACAP ) , whose *triggers* [neuronal differentiation] of the PC12 cell line via ERK1/2 activation , transiently activated Ras and induced the sustained GTP loading of Rap1 . Positive_regulation NEUROD4 IFI27 10837916 699513 Expression and *role* of ( kip1 ) in [neuronal differentiation] of embryonal carcinoma cells . Positive_regulation NEUROD4 MAP2K6 17976838 1831184 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Positive_regulation NEUROD4 MSX1 18385323 1893090 In contrast , few Lmx1a transduced cells matured into neurons , and overexpression *promoted* oligodendrogenesis rather than [neuronal differentiation] . Positive_regulation NEUROD4 S100B 23649988 2800697 enhanced significantly the early progenitor cell proliferation in the SGZ as well as cell survival and migration to the GCL , and *promoted* [neuronal differentiation] . Positive_regulation NEUROD4 S100B 9191095 437648 *promotes* [neuronal differentiation] and survival but may be detrimental to cells if overexpressed . Positive_regulation NEUROD4 TGM2 11166134 782917 Considering these and other previous findings , this study was carried out to determine whether is *involved* in [neuronal differentiation] of SH-SY5Y cells . Positive_regulation NEUROD4 TGM2 11166134 782925 These data indicate that is *necessary* and sufficient for [neuronal differentiation] of human neuroblastoma SH-SY5Y cells . Positive_regulation NEUROD4 TLR7 23843519 2816459 These results all suggest that negatively *regulates* [neuronal differentiation] . Positive_regulation NEUROD4 TMOD1 23638401 2779388 Our data demonstrate that is *involved* in [neuronal differentiation] for proper neurite formation and outgrowth , and that Tmod2 inhibits these processes . Positive_regulation NEUROD4 TNF 7690970 228698 Rat PC12 pheochromocytoma cells transiently transfected with TNF-p140trk chimeras , which contain the extracellular domain of TNF receptor and the transmembrane and cytoplasmic domains of p140trk , showed *dependent* [neuronal differentiation] and cell survival . Positive_regulation NEUROD4 WNT7A 19545542 2109885 Long-term activation of Wnt pathway by or by treatment with GSK3 inhibitors *promoted* a moderate increase of the [neuronal differentiation] and blocked gliogenesis . Positive_regulation NEUROD4 WNT7A 23629626 2795631 stimulated neural stem cell proliferation by activating the ß-catenin-cyclin D1 pathway and *promoted* [neuronal differentiation] and maturation by inducing the ß-catenin-neurogenin 2 pathway . Positive_regulation NEUROD6 ADRB2 9675299 520337 It was also observed that the elevated expression of the in the neuronal NT2 cells *resulted* in an enhanced level of [neuronal differentiation] compared to the wild type cells . Positive_regulation NEUROD6 CABP4 11563845 862975 An MN9D dopaminergic neuronal cell line overexpressing calbindin-D28K ( MN9D/Calbindin ) was established in order to investigate directly the potential *role* of in [neuronal differentiation] . Positive_regulation NEUROD6 EPHB2 10617116 656435 Thus , activation of may not be *essential* for [neuronal differentiation] in F11 cells and alphao may cause changes in NOG by inhibiting CREB activation . Positive_regulation NEUROD6 EPHB2 10772818 686262 However , activation and nuclear accumulation of were not *sufficient* to induce [neuronal differentiation] in SH-SY5Y , as demonstrated by the response to TPA in serum-free cultures . Positive_regulation NEUROD6 EPHB2 12865141 1111802 The results demonstrate that PKA and play a key role in KCl- and forskolin *induced* [neuronal differentiation] by integration of signals from both pathways . Positive_regulation NEUROD6 EPHB2 17976838 1831186 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Positive_regulation NEUROD6 EPHB2 18171671 1869716 Basic fibroblast growth factor induced [neuronal differentiation] of mouse bone marrow stromal cells *requires* FGFR-1 , , and transcription factor AP-1 . Positive_regulation NEUROD6 EPHB2 19615362 2142776 Our findings indicate that HA *inhibits* NGF induced [neuronal differentiation] of PC12 cells partially by inhibiting phosphorylation through RHAMM , and suggest that the binding of HA to RHAMM modifies the signaling pathways in PC12 cells treated with NGF . Positive_regulation NEUROD6 EPHB2 20525991 2301542 Both PtdCho biosynthesis and [neuronal differentiation] are *dependent* on activation . Positive_regulation NEUROD6 EPHB2 23907465 2822535 PKC dependent phosphorylation is *essential* for P2X7 receptor mediated [neuronal differentiation] of neural progenitor cells . Positive_regulation NEUROD6 EPHB2 9525930 495514 Induction of [neuronal differentiation] of the rat pheochromocytoma cell line , PC12 cells , by nerve growth factor (NGF) *requires* activation of the mitogen activated protein (MAP) kinase or extracellular signal regulated kinase ( ) . Positive_regulation NEUROD6 F2R 19686683 2126366 The phosphorylation of Mib by *results* in Mib degradation , repression of Notch signaling , and stimulation of [neuronal differentiation] . Positive_regulation NEUROD6 GPR115 12473665 1055671 Accordingly , we reported here that pituitary adenylate cyclase activating polypeptide ( PACAP ) , whose *triggers* [neuronal differentiation] of the PC12 cell line via ERK1/2 activation , transiently activated Ras and induced the sustained GTP loading of Rap1 . Positive_regulation NEUROD6 GPR132 12473665 1055660 Accordingly , we reported here that pituitary adenylate cyclase activating polypeptide ( PACAP ) , whose *triggers* [neuronal differentiation] of the PC12 cell line via ERK1/2 activation , transiently activated Ras and induced the sustained GTP loading of Rap1 . Positive_regulation NEUROD6 GPR87 12473665 1055740 Accordingly , we reported here that pituitary adenylate cyclase activating polypeptide ( PACAP ) , whose *triggers* [neuronal differentiation] of the PC12 cell line via ERK1/2 activation , transiently activated Ras and induced the sustained GTP loading of Rap1 . Positive_regulation NEUROD6 IFI27 10837916 699514 Expression and *role* of ( kip1 ) in [neuronal differentiation] of embryonal carcinoma cells . Positive_regulation NEUROD6 MAP2K6 17976838 1831192 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Positive_regulation NEUROD6 MSX1 18385323 1893091 In contrast , few Lmx1a transduced cells matured into neurons , and overexpression *promoted* oligodendrogenesis rather than [neuronal differentiation] . Positive_regulation NEUROD6 S100B 23649988 2800698 enhanced significantly the early progenitor cell proliferation in the SGZ as well as cell survival and migration to the GCL , and *promoted* [neuronal differentiation] . Positive_regulation NEUROD6 S100B 9191095 437649 *promotes* [neuronal differentiation] and survival but may be detrimental to cells if overexpressed . Positive_regulation NEUROD6 TGM2 11166134 782918 Considering these and other previous findings , this study was carried out to determine whether is *involved* in [neuronal differentiation] of SH-SY5Y cells . Positive_regulation NEUROD6 TGM2 11166134 782926 These data indicate that is *necessary* and sufficient for [neuronal differentiation] of human neuroblastoma SH-SY5Y cells . Positive_regulation NEUROD6 TLR7 23843519 2816460 These results all suggest that negatively *regulates* [neuronal differentiation] . Positive_regulation NEUROD6 TMOD1 23638401 2779389 Our data demonstrate that is *involved* in [neuronal differentiation] for proper neurite formation and outgrowth , and that Tmod2 inhibits these processes . Positive_regulation NEUROD6 TNF 7690970 228699 Rat PC12 pheochromocytoma cells transiently transfected with TNF-p140trk chimeras , which contain the extracellular domain of TNF receptor and the transmembrane and cytoplasmic domains of p140trk , showed *dependent* [neuronal differentiation] and cell survival . Positive_regulation NEUROD6 WNT7A 19545542 2109886 Long-term activation of Wnt pathway by or by treatment with GSK3 inhibitors *promoted* a moderate increase of the [neuronal differentiation] and blocked gliogenesis . Positive_regulation NEUROD6 WNT7A 23629626 2795632 stimulated neural stem cell proliferation by activating the ß-catenin-cyclin D1 pathway and *promoted* [neuronal differentiation] and maturation by inducing the ß-catenin-neurogenin 2 pathway . Positive_regulation NEUROG3 CPA4 16896938 1607804 Adenovirus mediated expression of [ngn3] ( also known as Neurog3 ) and Ptf1a in these cells *induced* expression of insulin and somatostatin , and of , respectively . Positive_regulation NF1 EPHB2 24211110 2891773 signaling *regulates* [Nf1] heterozygous neointima formation . Positive_regulation NF1 IL1B 15327898 1287573 Site directed mutagenesis and gel shift analyses revealed that PMA and strongly *induced* [nuclear factor-1 (NF-1)] binding to the JC virus enhancer region , increasing transcriptional activity of the viral early promoter . Positive_regulation NF1 MAP2K6 10442636 635745 This C17 neuronal cell induced [Nf1+/-] increase in proliferation was *blocked* by inhibition ( PD98059 ) , suggesting a p21-ras dependent effect . Positive_regulation NF1 MAP2K6 24211110 2891781 signaling *regulates* [Nf1] heterozygous neointima formation . Positive_regulation NFASC F11 8922386 397148 [Neurofascin] *induces* neurites by heterophilic interactions with axonal NrCAM while NrCAM requires on the axonal surface to extend neurites . Positive_regulation NFASC NRCAM 8922386 397149 [Neurofascin] *induces* neurites by heterophilic interactions with axonal NrCAM while requires F11 on the axonal surface to extend neurites . Positive_regulation NFAT5 EPHB2 17371162 1760197 Results of this study show that hypertonic activation of signaling *regulates* transactivation activity of [TonEBP] , modulating its function . Positive_regulation NFAT5 EPHB2 17371162 1760200 Expression of DN-ERK significantly suppressed , whereas , and CA-MEK1 *enhanced* , TAD activity of [TonEBP] . Positive_regulation NFAT5 EPHB2 23720348 2819679 High NaCl induced phosphorylation of p38 , , and SHP-1 *contributes* to activation of [NFAT5] . Positive_regulation NFAT5 TLR7 25044064 2956719 Unlike what is seen under hypertonic conditions , XO-derived ROS were selectively required for the induced [NFAT5] *activation* and NFAT5 binding to the IL-6 promoter in RAW 264.7 macrophages under isotonic conditions . Positive_regulation NFAT5 TLR7 25044064 2956739 In mouse peritoneal macrophages and human macrophages , ligation also *induced* [NFAT5] activation , which was dependent on XO and p38 kinase . Positive_regulation NFAT5 TLR7 25044064 2956749 The involvement of XO in [NFAT5] *activation* by was confirmed in RAW 264.7 macrophages implanted in BALB/c mice . Positive_regulation NFATC1 EPHB2 12810687 1102848 We show that in stimulated CD4+ T cells , TGF-beta inhibits phosphorylation and activation of the Tec kinase Itk , increase in intracellular Ca2+ levels , [NFATc] translocation , and *activation* of the mitogen activated protein kinase that together regulate T cell differentiation . Positive_regulation NFATC1 EPHB2 18433733 1908051 In conclusion , bavachalcone inhibits osteoclastogenesis by interfering with the and Akt signaling pathways and the *induction* of c-Fos and [NFATc1] during differentiation . Positive_regulation NFATC1 F2R 19351910 2088758 Here we show that activation *induces* binding of both p65/RelA and [NFATc1] to the NF-kappaB binding site localized in intron-1 of the ICAM-1 gene to initiate transcription in endothelial cells . Positive_regulation NFATC1 FHL1 19075112 2003066 binds with the calcineurin regulated transcription factor NFATc1 ( nuclear factor of activated T cells , cytoplasmic , calcineurin dependent 1 ) , *enhancing* [NFATc1] transcriptional activity . Positive_regulation NFATC1 JAG1 18710934 1968158 In contrast , induction of Notch signaling by or by ectopic expression of intracellular Notch2 *enhances* [NFATc1] promoter activity and expression and promotes osteoclastogenesis . Positive_regulation NFATC1 TNF 15824857 1394062 Only a few TRACP ( + ) multinucleate cells were formed , and *mediated* activation of JNK , NF-kappaB , and [NFATc1] was defective . Positive_regulation NFATC1 TNF 18201570 1863700 Adiponectin inhibits induction of *stimulated* [NFATc1] via the AMPK signaling . Positive_regulation NFATC1 TNF 18201570 1863702 Moreover , we observed that inhibition of AMP activated protein kinase abrogated gAd inhibition for *induced* [NFATc1] expression . Positive_regulation NFATC1 TNF 19756392 2183410 We demonstrate that silibinin can inhibit *induced* osteoclastogenesis as well as the expression of [NFATc1] and OSCAR . Positive_regulation NFATC1 TNF 21220349 2379348 *induced* [NFATc1] activity primed macrophages for enhanced osteoclastogenesis in response to RANKL . Positive_regulation NFATC1 TNF 21268069 2380710 While anti-osteoclastic phytoestrogen concentrations had no effect on caspase 3/7 activity or cell viability they did significantly reduce *induced* c-fos and [NFATc1] expression in an ER dependent manner and also inhibited NFATc1 nuclear translocation . Positive_regulation NFATC2 TNF 16500900 1549015 We report that interleukin-1 or increases expression of and *activates* [NFATc2] . Positive_regulation NFATC3 EDN2 15016802 1243416 The pro-hypertrophic basic helix-loop-helix protein p8 is degraded by the ubiquitin/proteasome system in a protein kinase B/Akt- and glycogen synthase kinase-3 dependent manner , whereas induction of p8 mRNA and renal mesangial cell hypertrophy *require* [NFAT4] . Positive_regulation NFE2 IL1B 11091227 754813 This study demonstrated for the first time the presence of IL-1 receptors on megakaryocytic cells and the *induction* of [NF-E2] by . Positive_regulation NFE2L2 EPHB2 11097862 755845 Inhibition of and p38 MAP kinases *inhibits* binding of [Nrf2] and induction of GCS genes . Positive_regulation NFE2L2 EPHB2 12657749 1080097 activation is *required* for [Nrf2] nuclear localization during pyrrolidine dithiocarbamate induction of glutamate cysteine ligase modulatory gene expression in HepG2 cells . Positive_regulation NFE2L2 EPHB2 21270272 2380792 Upregulation of [Nrf2] by its activator , Dh404 , in cardiomyocytes in vitro and in vivo prevented hydrogen peroxide- and diabetes *induced* activation and insulin signaling downregulation . Positive_regulation NFE2L2 EPHB2 23708697 2801592 Our data demonstrated that inhibition of and PI3K not only *suppressed* the nuclear accumulation of [Nrf2] protein but also decreased the expression of the Nrf2 protein . Positive_regulation NFE2L2 EPHB2 23776571 2802257 Interestingly , MEK inhibitor abrogated its nuclear translocation suggesting *role* of in basal and radiation induced [Nrf-2] activation in tumor cells . Positive_regulation NFE2L2 EPHB2 23788642 2824206 In this study , IQGAP1 ( IQ motif containing GTPase activating protein 1 ) , a new Nrf2 interaction partner that we have published previously , was found to modulate *mediated* [Nrf2] activation and induction of phase II detoxifying/antioxidant genes . Positive_regulation NFE2L2 EPHB2 24503931 2914147 DHF activated extracellular regulated kinase (ERK) and protein kinase B ( PKB , Akt ) in keratinocytes , while the and Akt inhibitors *attenuated* DHF enhanced [Nrf2] and HO-1 expression . Positive_regulation NFE2L2 MAP2K6 19336889 2052914 Eupatilin induced HO-1 expression and [Nrf2] were partly *attenuated* by inhibitor PD98059 and almost completely by phosphatidyl-inactiol 3 kinase (PI3K) inhibitor LY294002 , but not by c-Jun N-terminal kinase (JNK) inhibitor SP600125 or p38 mitogen activated protein kinase (MAPK) inhibitor SB202190 . Positive_regulation NFE2L2 MAP2K6 23788642 2824212 In this study , IQGAP1 ( IQ motif containing GTPase activating protein 1 ) , a new Nrf2 interaction partner that we have published previously , was found to modulate *mediated* [Nrf2] activation and induction of phase II detoxifying/antioxidant genes . Positive_regulation NFE2L2 TNF 21176673 2358244 After SCI , spinal cord water content , the expression of and MMP-9 all *increased* in both injured [Nrf2] ( +/+ ) and Nrf2 ( -/- ) mice compared with their respective sham operated mice . Positive_regulation NFE2L2 TNF 21670314 2451213 *mediates* the sustained activation of [Nrf2] in human monocytes . Positive_regulation NFE2L2 TNF 21670314 2451215 We found that in monocytes *induces* sustained [Nrf2] activation and Nrf2 cytoprotective gene induction in a TNFR1 dependent manner . Positive_regulation NFE2L2 TNF 21670314 2451218 We also showed that autocrine TNF secretion was responsible for this sustained Nrf2 response and that [Nrf2] *activation* by was mediated by the generation of reactive oxygen species . Positive_regulation NFE2L3 TNF 15388789 1354230 Furthermore , we showed that [NRF3] transcript and protein levels are *induced* by in JAR cells . Positive_regulation NFIB HBEGF 18559618 1924065 The present study focused on recent findings that cleavage of membrane anchored ( proHB-EGF ) , an EGFR ligand , *induces* translocation of the [carboxyl-terminal fragment (CTF)] of HB-EGF from the plasma membrane to the nucleus and regulates cell cycle . Positive_regulation NFIB TNF 20158498 2236169 In the present paper we provide evidence that MLK3 undergoes proteolysis to generate a stable [CTF] in *response* to different stimuli , including PMA and ( tumour necrosis factor alpha ) . Positive_regulation NFKB1 ADRB2 19167076 2043519 *regulate* Toll-like receptor 4-induced late-phase [NF-kappaB] activation . Positive_regulation NFKB1 ALOX5 10022882 590394 Reactive oxygen intermediate dependent [NF-kappaB] activation by interleukin-1beta *requires* <5-lipoxygenase> or NADPH oxidase activity . Positive_regulation NFKB1 ALOX5 11390371 842559 We show that in addition to inhibitors of secretory and cytosolic PLA(2)s , <5-lipoxygenase> inhibitors *attenuate* TNF-alpha- and IL-1beta stimulated [NF-kappaB] activation . Positive_regulation NFKB1 ALOX5 15161935 1295144 However , <5-lipoxygenase> inhibition had no effect on alpha7-nAChR mRNA expression , but significantly *inhibited* cell proliferation and activation of [NF-kappaB] and cyclooxygenase-2 , whereas NF-kappaB-specific inhibitor caffeic acid phenethyl ester reduced both cell proliferation and cyclooxygenase expression induced by NNK without affecting alpha7-nAChR mRNA level and 5-lipoxygenase expression . Positive_regulation NFKB1 ALOX5 17925309 1844099 In addition , the inhibition of <5-LO> by AA861 markedly *reduced* AcQ induced [nuclear factor kappa B (NF-kappa B)] activation . Positive_regulation NFKB1 ALOX5 9120300 423852 In transiently transfected HUVECs , [NF-kappa B-dependent] gene expression was *inhibited* by <5-lipoxygenase> inhibitors . Positive_regulation NFKB1 ANGPT1 17599743 1774566 In addition , *activated* [NF-kappaB] via Akt to promote cell growth , but also inhibited cell apoptosis via ERK and Akt . Positive_regulation NFKB1 ARSA 11238116 790485 The inhibitory effect of on IL-4 transcription was not *mediated* by decreased nuclear expression of the known salicylate target [nuclear factor (NF)-kappaB] and was accompanied by reduced binding of an inducible factor to an IL-4 promoter region upstream of , but not overlapping , the NF of activated T cells- and NF-kappaB binding P1 element . Positive_regulation NFKB1 ARSA 18174252 1875685 The effect of NO-ASA on NF-kappaB binding to DNA was significantly correlated with its effect on cell growth ( P < 0.05 ) indicating that the growth inhibitory effect of may be *mediated* by its effect on [NF-kappaB] . Positive_regulation NFKB1 CAPN8 12670502 1076045 These observations indicate that in monocyte/macrophage cells calcium signaling is involved in [NF-kappa B] *activation* through activation of and thus calpain inhibitors may be effective in inhibiting the activation of latently infected HIV . Positive_regulation NFKB1 CAPN8 14686903 1179508 Our data indicate that the Ca2+ dependent protease is *involved* in the [NF-kappaB] activation in neurons in response to N-methyl-d-aspartate receptor occupancy by glutamate . Positive_regulation NFKB1 CAPN8 14686903 1179564 [NF-kappaB] *activation* by may mediate the long-term effects of glutamate on neuron survival or memory formation . Positive_regulation NFKB1 CAPN8 16885359 1596329 In support , a inhibitor *impaired* [NF-kappaB] activation in MeWo ( cis1 ) cells . Positive_regulation NFKB1 CAPN8 9186501 436824 This suggests that *contributes* to silica induced I kappa B alpha degradation and [NF-kappa B] activation but not to LPS induced I kappa B alpha degradation and NF-kappa B activation . Positive_regulation NFKB1 CCND1 10409765 630555 NF-kappaB regulation of occurs at the transcriptional level and is *mediated* by direct binding of [NF-kappaB] to multiple sites in the cyclin D1 promoter . Positive_regulation NFKB1 CCND1 10464245 640345 Induction of by Rac1 *required* both an [NF-kappaB] and an ATF-2 binding site . Positive_regulation NFKB1 CCND1 15893541 1407602 To determine whether the NNK induced [NFkappaB] activation and *induction* were also observed in vivo , A/J mice were treated with NNK ( 9.1 mg ) for 20 weeks and the results showed a significant induction of cyclin D1 and NFkappaB translocation determined by immunoblotting analyses . Positive_regulation NFKB1 CCND1 16230390 1470079 The induction of by arsenite *required* [nuclear factor-kappaB (NF-kappaB)] activation , because the inhibition of IkappaB phosphorylation by overexpression of the dominant negative mutant , IKKbeta-KM , impaired arsenite induced cyclin D1 expression and G1-S transition . Positive_regulation NFKB1 CCND1 16940298 1627459 Here we show that HBx up-regulates and that this process is *mediated* by the [NF-kappaB2] ( p52 ) /BCL-3 complex . Positive_regulation NFKB1 CCND1 17008396 1674083 To further understand the mechanism of TNF stimulated growth of primary MEC , the requirement for [NFkappaB1/p50] , and the *role* of in TNF stimulated growth were examined . Positive_regulation NFKB1 CCND1 17440100 1729479 P = 0.036 versus gemcitabine alone ) , Ki-67 proliferation index ( P = 0.030 versus control ) , [NF-kappaB] *activation* , and expression of NF-kappaB regulated gene products ( , c-myc , Bcl-2 , Bcl-xL , cellular inhibitor of apoptosis protein-1 , cyclooxygenase-2 , matrix metalloproteinase , and vascular endothelial growth factor ) compared with tumors from control mice treated with olive oil only . Positive_regulation NFKB1 CD14 10996025 733676 In the present study , we investigated the *role* of and complement receptor type 3 (CR3) in mediating NO production and [NF-kappaB/Rel] activation induced by angelan and LPS . Positive_regulation NFKB1 CD14 11343695 813953 The binding of lipopolysaccharide to its receptor *activates* protein kinase C and [nuclear factor-kappaB (NF-kappaB)] . Positive_regulation NFKB1 CD14 11546774 882117 In conclusion , H. pylori induced [NF-kappaB] activation in epithelial cells is dependent on cag PAI and contact but does not *involve* and IRAK , whereas in macrophage/monocytic cells it is independent of cag PAI or contact but involves CD14 and TLR4 . Positive_regulation NFKB1 CD14 11779220 900060 dependent *activation* of [NF-kappaB] by filarial parasitic sheath proteins . Positive_regulation NFKB1 CD14 11779220 900067 Herein we provide evidence that FPS activation of [NF-kappaB] can be *augmented* by the cell surface expression of . Positive_regulation NFKB1 CD14 12062631 953258 Recent evidence supports the suggestion that endotoxin induced signal transduction begins with mediated activation of Toll-receptor 4 and subsequent *activation* of [nuclear factor-kappa B (NF-kappa B)] binding activity . Positive_regulation NFKB1 CD14 12379680 997302 These results indicate that the polysaccharide portion covalently bound to lipid A plays the principal role in Salmonella LPS induced *activation* of [NF-kappaB] through human . Positive_regulation NFKB1 CD14 15731076 1377583 Our results show that and TLR4 are *necessary* for low-dose ( 300-microg/ml ) LPS induced microvascular leakage , [NF-kappaB] activation , neutrophil influx , cytokine and chemokine ( KC , macrophage inflammatory protein 2 , tumor necrosis factor alpha , interleukin-6 ) expression , and subsequent lung damage . Positive_regulation NFKB1 CD14 16879219 1593845 Lipopolysaccharide induced decreased protein S expression in liver cells is mediated by MEK/ERK signaling and [NFkappaB] *activation* : involvement of membrane bound and toll-like receptor-4 . Positive_regulation NFKB1 CD14 16879219 1593851 Antirat and antirat TLR-4 antibodies inhibited LPS induced NFkappaB activation , and a [NFkappaB] inhibitor *suppressed* LPS induced decreased PS expression in both cells . Positive_regulation NFKB1 CD14 16879219 1593871 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by MEK/ERK signaling and [NFkappaB] activation and that membrane bound and TLR-4 are *involved* in this mechanism . Positive_regulation NFKB1 CD14 17522215 1767214 [NF-kappaB] activation in HEK293-TLR2 cells ( HEK293 cells transfected with TLR2 ) by EBV was not *enhanced* by the presence of . Positive_regulation NFKB1 CD14 18458151 1927016 Expression of markedly enhanced LTA binding to the plasma membrane and also *enhanced* [NF-kappaB] activation . Positive_regulation NFKB1 CD14 19840871 2203178 Intriguingly , MD2 did play a significant role in activating [NF-kappaB] by PG in the *presence* of . Positive_regulation NFKB1 CD14 20394816 2282075 The evidence suggests that these changes are a likely consequence of increased hippocampal expression of and TLR4 , and [NFkappaB] *activation* in SIGIRR ( -/- ) mice . Positive_regulation NFKB1 CD14 9574560 502558 This study was undertaken to evaluate the *role* of and complement receptors type 3 (CR3) and 4 ( CR4 ) in mediating TNF release and [NF-kappaB] activation induced by LPS and cell wall preparations from group B streptococci type III ( GBS ) . Positive_regulation NFKB1 CLU 17056579 1636649 We propose that in RA joints , high levels of extracellular and low expression of intracellular CLU may *enhance* [NF-kappaB] activation and survival of the synoviocytes . Positive_regulation NFKB1 CLU 23270201 2709664 The genes that are down-regulated in stress are cell cycle inhibitors , apoptosis related genes , antiproliferative cytokines and , the [NF-kappaB] *inhibitor* . Positive_regulation NFKB1 CTGF 16303051 1490774 *Activation* of [nuclear factor kappa B (NF-kappaB)] by connective tissue growth factor ( ) is involved in sustaining the survival of primary rat hepatic stellate cells . Positive_regulation NFKB1 CTGF 16303051 1490776 *induced* IkappaBalpha phosphorylation and degradation as well as nuclear accumulation of [NF-kappaB] . Positive_regulation NFKB1 CTGF 16408113 1513485 *enhanced* the mRNA expression and protein release of fractalkine , MCP-1 , and RANTES , the expression of phospho ( P ) -p42/44 mitogen activated protein kinase (MAPK) , P-phosphoinositide 3-kinase (PI3-K) , P-Akt , and activity of [nuclear factor-kappaB (NF-kappaB)] in mesangial cells . Positive_regulation NFKB1 CTGF 16408113 1513532 P-PI3-K blockade downregulated the *stimulated* expression of P-PI3-K , P-Akt , and [NF-kappaB] but not P-p42/44 MAPK , and partially decreased the release of the above chemokines . Positive_regulation NFKB1 CTGF 16408113 1513541 LXA ( 4 ) dose-dependently inhibited the *stimulated* mRNA expression and protein release of the above chemokines , and the expression of P-p42/44MAPK , P-PI3-K , P-Akt , and [NF-kappaB] . Positive_regulation NFKB1 CTGF 16707502 1584472 Thus , mechanical stretch induced changes in actin dynamics mediate [NF-kappaB] activation and *induce* gene expression , which probably initiates the fibrotic reactions observed in mechanical overload associated pathologies . Positive_regulation NFKB1 CTGF 18639630 1954657 *stimulated* binding of [NF-kappaB] to the IL-6 promoter , and siRNA targeting the NF-kappaB subunit RelA interfered with CTGF induced IL-6 expression , implicating the NF-kappaB pathway in the mediation of the CTGF effect . Positive_regulation NFKB1 CTNNAL1 17952117 1889010 , a Rho signalling component , can *regulate* [NF-kappaB] through binding to IKK-beta , and confers resistance to apoptosis . Positive_regulation NFKB1 CTNNAL1 17952117 1889018 Ectopic expression of *augmented* [NF-kappaB] activity , promoted cell migration and increased resistance to apoptosis , whereas knockdown experiments showed the opposite effects . Positive_regulation NFKB1 EDN2 11692473 876493 The subsequent [NF-kappa B] activation probably *involves* participation of signaling and , perhaps , NF-AT3 activation . Positive_regulation NFKB1 EDN2 15860794 1425769 MBP1 *induced* activation of neural [nuclear factor (NF)-kappaB] , from 10 min to 12 h , declining by 24 h , whereas induced a short lived activation of NF-kappaB . Positive_regulation NFKB1 EPHB2 10878013 722413 We have shown that both the and p38 mitogen activated protein ( MAP ) kinases are necessary for cytokine gene transcription and that the p38 MAP kinase is *required* for [NF-kappaB-driven] transcription , so we hypothesized that the MEK -- > ERK pathway regulated NF-kappaB-driven transcription as well . Positive_regulation NFKB1 EPHB2 11278990 811628 Specific effects on [NF-kappa B-inducing] kinase activity and on the coordinate *activation* of and p38 MAPK . Positive_regulation NFKB1 EPHB2 11371570 834866 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and and *activation* of cAMP-responsive element binding protein ( CREB ) , [NF-kappaB] , and E2F ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation NFKB1 EPHB2 11741913 904971 Analyzing the effects of several inhibitors or mutant receptors revealed that this [NF-kappa B] activation is *mediated* neither by nor by the phosphatidylinositol 3-kinase pathway but by STAT5 . Positive_regulation NFKB1 EPHB2 11742864 887447 These data suggest that activity is *required* for persistent [NF-kappaB] activation by IL-1beta that is necessary for iNOS gene expression . Positive_regulation NFKB1 EPHB2 11773061 916287 Moreover , the NF-kappa B promoter activity decreased with overexpression of dominant negative ERK expression constructs , and EMSA analyses further support the hypothesis that acts upstream of NF-kappa B and *regulates* the [NF-kappa B] DNA binding activity . Positive_regulation NFKB1 EPHB2 12143039 969603 An adv expressing dominant negative ( dn ) TRAF2 inhibited only JNK and not or [NF-kappa B] *activation* . Positive_regulation NFKB1 EPHB2 12426209 1014368 Treatment of VSMCs with PDGF or EGF alone potently induced phosphorylation and DNA synthesis but did not *induce* [NF-kappaB] activation or iNOS expression . Positive_regulation NFKB1 EPHB2 12426209 1014379 Inhibition of phosphorylation with selective inhibitors ( PD98059 or U0126 ) *attenuated* interleukin-1beta induced persistent [NF-kappaB] activation and iNOS expression in either the absence or presence of the growth factors . Positive_regulation NFKB1 EPHB2 12677169 1076925 We demonstrate , for the first time , that glycated albumin activates RAW cell ERK and promotes *dependent* increases in TGF-beta(1) production , oxidative stress , and [NF-kappa B] activation . Positive_regulation NFKB1 EPHB2 12694399 1080740 These results indicate that D2R induced [NF-kappaB] *activation* through may be involved in activation of the NCAM promoter , and additionally that other protein kinases such as CaM KII and p38 MAPK also regulate NCAM expression . Positive_regulation NFKB1 EPHB2 12934647 1132825 Sodium salicylate inhibits expression of COX-2 through suppression of and subsequent [NF-kappaB] *activation* in rat ventricular cardiomyocytes . Positive_regulation NFKB1 EPHB2 14581482 1186909 In cultured rat vascular smooth muscle cells , sustained activation of is *required* for interleukin-1beta to persistently activate [NF-kappaB] . Positive_regulation NFKB1 EPHB2 14715266 1197297 These data suggest that ERK and *dependent* [NF-kappaB] activation is required for oxidative stress induced inhibition of osteoblastic differentiation in rabbit BMSC and calvarial osteoblasts . Positive_regulation NFKB1 EPHB2 15106733 1240531 Salicylate regulates COX-2 expression through and subsequent [NF-kappaB] *activation* in osteoblasts . Positive_regulation NFKB1 EPHB2 15147892 1248122 HHE increased the activity of p38 MAPK and extracellular signal regulated kinase ( ERK ) , but not c-jun NH ( 2 ) -terminal kinase , indicating that p38 MAPK and are closely *involved* in HHE induced [NF-kappaB] transactivation . Positive_regulation NFKB1 EPHB2 15210577 1268078 Regulation of metalloproteinases and [NF-kappaB] *activation* in rabbit synovial fibroblasts via E prostaglandins and : contrasting effects of nabumetone and 6MNA . Positive_regulation NFKB1 EPHB2 15485634 1320647 CD40- and BAFF mediated survival is significantly increased in Act1-deficent B cells , with stronger IkappaB phosphorylation , processing of [NF-kappaB2] ( p100/p52 ) , and *activation* of JNK , , and p38 pathways , indicating that Act1 negatively regulates CD40- and BAFF mediated signaling events . Positive_regulation NFKB1 EPHB2 15589482 1356222 In addition , luteolin inhibited TNF-alpha induced phosphorylation of p38 MAPK and , IkappaB degradation , and [NF-kappaB] *activation* . Positive_regulation NFKB1 EPHB2 15843535 1398459 To identify a molecular basis for this receptor cross-talk , we examined activation and [NF-kappaB] *induction* . Positive_regulation NFKB1 EPHB2 15870903 1405557 In addition , GA inhibited TNF-alpha induced phosphorylation of p38 MAPK and , I kappa B alpha degradation , and [NF-kappa B] *activation* . Positive_regulation NFKB1 EPHB2 16326421 1488356 Together these results suggest that while gamma-IR and Ras both contribute to the upregulation of CD23 expression via NF-kappaB Raf or is not *involved* in gamma-IR induced [NF-kappaB] activation . Positive_regulation NFKB1 EPHB2 16436136 1516433 The induction of RANTES by SCF or TNF-alpha was mediated by ERK and [NF-kappaB] , respectively , and SCF induced MIP-1beta release was *mediated* by . Positive_regulation NFKB1 EPHB2 16563718 1631149 Furthermore , inhibition of activity by PD98059 and PI3K/Akt activity by LY294002 or wortmannin significantly *reduced* the LA-induced activation of [nuclear factor kappa B (NF-kappaB)] . Positive_regulation NFKB1 EPHB2 16705144 1638288 Selective suppression of or p38 MAP kinase significantly *attenuated* activation of [NF-kappaB] in mesangial cells triggered by coculture with isolated glomeruli . Positive_regulation NFKB1 EPHB2 16870149 1593097 However , this activation of [NF-kappaB] *requires* the PI3K and PKC signaling pathways , but not or JNK . Positive_regulation NFKB1 EPHB2 16966488 1627826 Phosphorylation of *led* to an activation of [NFkappaB] , as indicated by increased p50 subunit expression in nuclear extracts , and increased mRNA levels of the antioxidant enzyme manganese-superoxide dismutase ( MnSOD ) . Positive_regulation NFKB1 EPHB2 16972253 1627866 The increase in oxidative stress induced [NF-kappaB] activity was *mediated* by activation of . Positive_regulation NFKB1 EPHB2 16996785 1746974 [NF-kappaB] expression induced by safrole in fibroblasts may be *mediated* by activation and COX-2 signal transduction pathway . Positive_regulation NFKB1 EPHB2 17478933 1738642 The inhibition of can *suppress* the DNA binding activity of [NF-kappaB] and the cell proliferation mediated by HCV NS3 protein in a dose dependent manner . Positive_regulation NFKB1 EPHB2 17499198 1739929 Molecular mechanisms that govern attenuation of the levels of mRNAs and proteins of these cytokines and iNOS revealed that the PC extract inhibited LPS stimulated phosphorylation of and *activation* of [NF-kappaB] . Positive_regulation NFKB1 EPHB2 17602748 1842186 Immunofluorescence analysis detected nuclear translocation of the [NF-kappaB] p50 subunit and this was *blocked* by inhibitor , indicating that GITRL stimulation induced ERK1/2 phosphorylation and subsequent activation of NF-kappaB . Positive_regulation NFKB1 EPHB2 17891781 1888855 Furthermore , inhibitors ( U0126 and PD98059 ) *suppressed* LPA stimulated activation of [NF-kappaB] and p65 phosphorylation whereas wortmannin showed no effect on NF-kappaB activation . Positive_regulation NFKB1 EPHB2 18080123 1903347 The inhibitors of NF-kappaB , JNK and p38 , but not , decreased IL-1beta enhanced MMP-1 , MMP-3 and NO production , respectively , and 100 nM celecoxib *down-regulated* the phosphorylation of [NF-kappaB] and JNK but has no effect on either p38 or ERK . Positive_regulation NFKB1 EPHB2 18335517 1925144 These data indicate that near-physiological concentrations of Mn potentiate cytokine induced expression of NOS2 and production of NO in astrocytes via activation of sGC , which promotes *dependent* enhancement of [NF-kappaB] signaling . Positive_regulation NFKB1 EPHB2 18434625 1920903 Collectively , our data demonstrate that SP enhances selective inflammatory chemokine production by murine macrophages via MAPK *mediated* [NF-kappaB] activation . Positive_regulation NFKB1 EPHB2 18442745 1900595 SNP induced the phosphorylation of p38 MAPK and , degradation and phosphorylation of IkappaB , and *activation* of [NF-kappaB] . Positive_regulation NFKB1 EPHB2 19093035 2003826 Pre-treatment with the MAP kinase kinase (MEK)-1/2 inhibitor U0126 showed that cytokine triggered [NF-kappaB] nuclear translocation and transcriptional activity are *mediated* by activation of . Positive_regulation NFKB1 EPHB2 19214689 2034140 Mechanical stress on the LHB and RI in the shoulder may *induce* and JNK to express [NF-kappaB] by CD29 to develop capsule contracture , producing MMP-3 , IL-6 , and VEGF . Positive_regulation NFKB1 EPHB2 19429670 2106929 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either inhibitor , p38MAPK inhibitor or [NF-kappaB] *inhibitor* . Positive_regulation NFKB1 EPHB2 19472212 2102238 JAKs inhibitors suppressed IFN-gamma plus TNF-alpha induced production of CXCL10 in parallel with activation of STAT1 and NF-kappaB , while inhibitor *suppressed* production of CXCL10 as well as activation of [NF-kappaB] , but not that of STAT1 . Positive_regulation NFKB1 EPHB2 19619321 2118169 Unlike Paclitaxel , ARRY-520 did not induce [NF-kappaB] activation , did not enhance cytokine secretion , nor *induce* phosphorylation in Type I EOC cells . Positive_regulation NFKB1 EPHB2 20054486 2177438 HF6-FC exerts its inhibitory effects by suppression of p38 and [NF-kappaB] but *activation* of . Positive_regulation NFKB1 EPHB2 20121399 2206956 In THP-1 cells , p38 , , and JNK inhibition *increased* [NF-kappaB] and Sp1 binding to the IL-12p40 promoter , while inhibiting AP-1 binding . Positive_regulation NFKB1 EPHB2 20537708 2279374 In conclusion , all these findings demonstrate a key *role* of and TLR4 in association with [NF-kappaB] in IL-10 modulation induced by T. cruzi and suggest that this regulatory effect involves parasite-DC interactions not described yet . Positive_regulation NFKB1 EPHB2 20546116 2308511 Blockage of moesin function interrupts the LPS response through an inhibition of MyD88 , IRAK and TRAF6 , negatively affecting subsequent activation of the MAP kinases ( p38 and ) , [NF-kappaB] *activation* and translocation to the nucleus . Positive_regulation NFKB1 F2R 10372815 622098 *Activation* of [NFkappaB] via either or PAR-2 does not predict mitogenesis . Positive_regulation NFKB1 F2R 12215488 986046 Cotransfection of RGS3T , a regulator of G-protein signaling that inhibits Galpha ( q ) , or alpha-transducin ( Galpha ( t ) ) , a scavenger of the Gbetagamma , markedly decreased [NF-kappaB] activity *induced* by activation . Positive_regulation NFKB1 F2R 12215488 986053 These results support a model in which ligation of *induces* [NF-kappaB] activation and ICAM-1 transcription by the engagement of parallel Galphaq/PKC-delta and Gbetagamma/PI3-kinase pathways that converge at Akt . Positive_regulation NFKB1 F2R 16052512 1460018 mediated [NFkappaB] *activation* promotes survival of prostate cancer cells through a Bcl-xL dependent mechanism . Positive_regulation NFKB1 F2R 16052512 1460033 Inhibition of p38 and ERK1/2 by SB-203589 and PD-098059 , respectively , did not abrogate NFkappaB activity , suggesting an independent *induction* of [NFkappaB] by stimulation . Positive_regulation NFKB1 F2R 16467309 1548199 Activation of or PAR-2 *promoted* nuclear translocation and phosphorylation of [p65-NF-kappaB] , and thrombin induced but not PAR-2 induced p65-NF-kappaB phosphorylation was reduced by inhibition of MEK or p38MAPK . Positive_regulation NFKB1 F2R 19931359 2198026 Then we investigated whether the binding of APC to is *required* to control [NF-kappaB] activation . Positive_regulation NFKB1 FAS 10022897 590539 Activation dependent transcriptional regulation of the human promoter *requires* [NF-kappaB] p50-p65 recruitment . Positive_regulation NFKB1 FAS 10823821 714856 In HeLa cells , induction of apoptosis and [nuclear factor kappaB (NF-kappaB)] activation *initiated* by TRAIL/Apo2L or the agonistic Apo1/Fas-specific monoclonal antibody require the presence of cycloheximide ( CHX ) . Positive_regulation NFKB1 FAS 10823821 714860 Inhibition of caspases prevented *induced* apoptosis , but not [NF-kappaB] activation , indicating that both pathways bifurcate upstream of the receptor-proximal caspase-8 . Positive_regulation NFKB1 FAS 11464292 839433 Inhibition of protein kinase C by Gö6983 sensitized these cells to apoptotic challenges and strongly diminished *activation* of [NF-kappaB] by and TRAIL . Positive_regulation NFKB1 FAS 11689460 876269 CD40 activation induced , *dependent* apoptosis and [NF-kappaB/AP-1] signaling in human intrahepatic biliary epithelial cells . Positive_regulation NFKB1 FAS 12244143 990502 Fas resistance of leukemic eosinophils is due to *activation* of [NF-kappa B] by ligation . Positive_regulation NFKB1 FAS 12244143 990508 Although activation of NF-kappaB by ligation of Fas ( CD95/Apo-1 ) , a member of the TNFR family , has been observed in a few studies , mediated [NF-kappaB] *activation* has not previously been shown to protect cells from apoptosis . Positive_regulation NFKB1 FAS 12244143 990510 We examined the *induced* [NF-kappaB] activation and its antiapoptotic effects in a leukemic eosinophil cell line , AML14.3D10 , an AML14 subline resistant to Fas mediated apoptosis . Positive_regulation NFKB1 FAS 12883671 1116458 stimulation *activates* [NF-kappaB] in SK-Hep1 hepatocellular carcinoma cells . Positive_regulation NFKB1 FAS 12883671 1116462 However , the *role* of in induction of [NF-kappaB] activation in HCC cells is not well understood . Positive_regulation NFKB1 FAS 12883671 1116468 stimulation *induced* [NF-kappaB] activation in a dose dependent manner in SK-Hep1 and HepG2 cell lines , but not in HLE cells . Positive_regulation NFKB1 FAS 14625298 1200947 Caffeic acid phenethyl ester induces apoptosis by inhibition of [NFkappaB] and *activation* of in human breast cancer MCF-7 cells . Positive_regulation NFKB1 FAS 15252018 1295923 We conclude that induce insulin resistance and *activates* [NFkappaB] in L6 cells . Positive_regulation NFKB1 FAS 15289496 1278452 [NFkappaB] *activation* by is mediated through FADD , caspase-8 , and RIP and is inhibited by FLIP . Positive_regulation NFKB1 FAS 15289496 1278454 Remarkably , the enzymatic activity of the latter was dispensable for *induced* [NFkappaB] signaling pointing to a scaffolding related function of caspase-8 in nonapoptotic Fas signaling . Positive_regulation NFKB1 FAS 15467462 1347260 In fact overexpression of apoptosis inhibitors such as Bcl-2 or c-FLIPL in these cells results in decreased *activation* of [NF-kappaB] through . Positive_regulation NFKB1 FAS 15514680 1328472 Induction of apoptosis and *activation* of [NF-kappaB] by require different signalling thresholds . Positive_regulation NFKB1 FAS 16465219 478751 *activates* [NF-kappaB] and induces apoptosis in T-cell lines by signaling pathways distinct from those induced by TNF-alpha . Positive_regulation NFKB1 FAS 16465219 478756 Surprisingly , induced signaling also *triggered* the activation of [NF-kappaB] in T cells , yet the kinetics of NF-kappaB induction by Fas was markedly delayed . Positive_regulation NFKB1 FAS 16646028 1557242 stimulation *activated* [NF-kappaB] and AP-1 , and this response required caspase activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation NFKB1 FAS 16855770 1646099 [NF-kappa B] is *activated* by increased in CORT induced Leydig cell apoptosis . Positive_regulation NFKB1 FAS 17118453 1667833 Besides the apoptosis signaling pathway , ligation also *induces* the activation of [NF-kappaB] . Positive_regulation NFKB1 FAS 17395209 1766126 TNFR1 ligation *induces* [NFkappaB] activation and the upregulation of chemokines MCP-1 and IL-8 , as well as adhesion molecules ICAM-1 and VCAM-1 , while and DR5 triggering activate the extracellular signal regulated kinases-1 and -2 ( Erk 1/2 , p42/44 MAPK ) inducing the release of matrix metalloproteinase 9 (MMP9) by BBB derived ECs . Positive_regulation NFKB1 FAS 18348981 1905874 In conclusion , genetic inactivation of c-Met in mouse hepatocytes caused defects in redox regulation , which may account for the increased sensitivity to *induced* apoptosis and adaptive up-regulation of [NF-kappaB] survival signaling . Positive_regulation NFKB1 FAS 18448526 1921250 Therefore , our results are in agreement with a model where LMP1 dependent [NF-kappaB] activation *induces* overexpression and autoactivation that could overwhelm the antiapoptotic effect of NF-kappaB , revealing an ambivalent function of LMP1 in cell survival and programmed cell death . Positive_regulation NFKB1 FAS 20212524 2223106 We established an integrated kinetic mathematical model for *mediated* apoptotic and [NF-kappaB] signaling . Positive_regulation NFKB1 FAS 20379197 2300419 In mutant PIK3CA expressing cells , tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) and *stimulated* [nuclear factor kappaB (NFkappaB)] activation , invasion , and transition to an amoeboid-like morphology . Positive_regulation NFKB1 FAS 8597871 342616 With regard to their cytoplasmic homology region , we investigated whether like the TNF-R *activates* [nuclear factor kappa B (NF-kappa B)] , using human SV80 fibroblasts transfected with the cDNA encoding human Fas . Positive_regulation NFKB1 FAS 8621545 360061 The ( APO-1/Fas ) receptor *activates* [NF-kappaB] independently of its cytotoxic function . Positive_regulation NFKB1 FAS 8621545 360063 In an effort to understand CD95 mediated signaling , we assessed possible changes in the DNA binding activity of [NF-kappaB] as a *result* of engagement in various tumor cells . Positive_regulation NFKB1 FAS 8621545 360065 By performing electrophoresis mobility shift assays , we show that can *stimulate* the DNA binding activity of [NF-kappaB] in a variety of cells , irrespective of their sensitivity or resistance to CD95 mediated cytotoxicity . Positive_regulation NFKB1 FAS 9020361 413100 MAP3K related kinase involved in [NF-kappaB] *induction* by TNF , and IL-1 . Positive_regulation NFKB1 FAS 9500443 490763 We demonstrate that ligation of ( Fas/APO1 ) , a potent apoptotic stimulus in lymphocytes , *results* in repression of [NF-kappaB] activity in Jurkat T cells by inducing the proteolytic cleavage of NF-kappaB p65 ( Rel A ) and p50 . Positive_regulation NFKB1 FAS 9990295 597307 Cell death does correlate with alterations in NF-kappa B activity : the NSAIDs , butyrate and H2O2 enhance c-Rel complex formation by TNF-alpha and provide an overall enhancement of [NF-kappa B] *activation* by . Positive_regulation NFKB1 FOXO1 17972158 1850073 The *activation* of [NF-kappaB] through Akt induced phosphorylation during aging and its modulation by calorie restriction . Positive_regulation NFKB1 FOXO1 18226221 1884254 Phosphatidylinositol 3-kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of and non-canonical *activation* of [NFkappaB] transcription factors . Positive_regulation NFKB1 FUT4 17410536 1736233 In an attempt to identify an effective therapeutic agent for pancreatic cancer , the authors studied the *role* of , a synthetic serine protease inhibitor , in the inhibition of [NF-kappaB] activation and the induction of apoptotic responses . Positive_regulation NFKB1 GPR115 21159881 2385030 Phosphorylation and polyubiquitination of transforming growth factor beta activated kinase 1 are necessary for *activation* of [NF-kappaB] by the Kaposi 's sarcoma associated herpesvirus . Positive_regulation NFKB1 GPR132 21159881 2385019 Phosphorylation and polyubiquitination of transforming growth factor beta activated kinase 1 are necessary for *activation* of [NF-kappaB] by the Kaposi 's sarcoma associated herpesvirus . Positive_regulation NFKB1 GPR87 21159881 2385099 Phosphorylation and polyubiquitination of transforming growth factor beta activated kinase 1 are necessary for *activation* of [NF-kappaB] by the Kaposi 's sarcoma associated herpesvirus . Positive_regulation NFKB1 HRH1 11641442 872156 In this study , we show that the , which is also an important player in allergic and inflammatory conditions , *activates* [NF-kappa B] in both a constitutive and agonist dependent manner . Positive_regulation NFKB1 ID1 17012234 1641398 Aberrant activation of NF-kappaB transcription factors has been shown to contribute to the developmental defects , but it is not clear whether [NF-kappaB] activation is directly *due* to expression or is secondary to an abnormal thymic environment in Id1 transgenic mice . Positive_regulation NFKB1 ID1 17012234 1641402 Here , by using a T cell line model , we demonstrate that expression stimulates basal levels of NF-kappaB activity and further *enhances* [NF-kappaB] activation upon T cell receptor ( TCR ) signaling achieved by anti-CD3 and anti-CD28 stimulation . Positive_regulation NFKB1 IFI27 10353611 617648 In contrast to INK4 proteins , the cell cycle inhibitor *enhances* [NF-kappaB] transactivation activity . Positive_regulation NFKB1 IFI27 17702989 1788819 Thus , is an important [NF-kappaB] *activator* in DCs and involved in IL-12 production , which may account for a T(h)1-prone phenotype of BWF1 mice . Positive_regulation NFKB1 IL1B 10022882 590395 Reactive oxygen intermediate dependent [NF-kappaB] *activation* by requires 5-lipoxygenase or NADPH oxidase activity . Positive_regulation NFKB1 IL1B 10022882 590414 Stimulation of lymphoid cells with *led* to ROI production and [NF-kappaB] activation , which could both be blocked by antioxidants or FLAP inhibitors , confirming that 5-LOX was the source of ROIs and was required for NF-kappaB activation in these cells . Positive_regulation NFKB1 IL1B 10022882 590422 This pathway involves the Rac1 and Cdc42 GTPases , two enzymes which are not required for [NF-kappaB] *activation* by in epithelial cells . Positive_regulation NFKB1 IL1B 10022882 590424 In conclusion , three different cell-specific pathways lead to [NF-kappaB] *activation* by : a pathway dependent on ROI production by 5-LOX in lymphoid cells , an ROI- and 5-LOX independent pathway in epithelial cells , and a pathway requiring ROI production by NADPH oxidase in monocytic cells . Positive_regulation NFKB1 IL1B 10066820 593913 In contrast to the inability of LPS and IL-1beta alone to induce the expression of iNOS , both LPS and individually stimulated MAP kinase activity and *induced* DNA binding and transcriptional activity of [NF-kappaB] . Positive_regulation NFKB1 IL1B 10066820 593915 Moreover , wortmannin had no effect on LPS- or mediated *activation* of MAP kinase and [NF-kappaB] , suggesting that wortmannin induced the expression of iNOS in LPS- or IL-1beta stimulated C6 glial cells without modulating the activation of MAP kinase and NF-kappaB . Positive_regulation NFKB1 IL1B 10074208 594749 In contrast , infection with EZ did not block *activation* of the transcription factor [NF-kappaB] by . Positive_regulation NFKB1 IL1B 10089132 600004 Because NF-kappaB is necessary for MCP-1 gene expression , the effect of p38 kinase inhibition on *induction* of [NF-kappaB] was measured . Positive_regulation NFKB1 IL1B 10089132 600014 PD 098059 , a selective inhibitor of the ERK activating kinase MEK1 , had no effect on induced MCP-1 mRNA or protein levels , or on IL-1beta *activation* of [NF-kappaB] . Positive_regulation NFKB1 IL1B 10218970 608579 Both and TNF-alpha *activated* [nuclear factor (NF)-kappaB] as demonstrated by electrophoretic mobility shift assay . Positive_regulation NFKB1 IL1B 10232679 611403 Treatment with N ( G ) -nitro-L-arginine methyl ester ( L-NAME ) did not affect initial *activation* of [NF-kappaB] by , but unveiled an inhibitory effect of NO generation on NF-kappaB activity after 4 h . Positive_regulation NFKB1 IL1B 10336492 615484 The activation of [NF-kappaB] and the subsequent cytokine induced neutrophil chemoattractant induction in *response* to were inhibited by proteasome inhibitors , MG132 and proteasome inhibitor I. Translocation of NF-kappaB into nuclei occurs by the phosphorylation , multi-ubiquitination , and degradation of IkappaBalpha , a regulatory protein of NF-kappaB . Positive_regulation NFKB1 IL1B 10336492 615488 These results indicate that the transient translocation of [NF-kappaB] in *response* to may be partly dependent on transient proteasome activation . Positive_regulation NFKB1 IL1B 10391885 626761 IkappaBalphaM was resistant to stimulus dependent degradation and suppressed [NF-kappaB] activation *induced* by TNF-alpha ( 10 ng/ml ) or ( 10 ng/ml ) . Positive_regulation NFKB1 IL1B 10430178 633568 and TNF-alpha *stimulated* nuclear [NF-kappaB] levels by about fourfold and fivefold , respectively , in HASMCs . Positive_regulation NFKB1 IL1B 10438477 634836 induced type II-sPLA ( 2 ) gene dose- and time-dependently and *increased* the binding of [NFkappaB] to a specific site of type II-sPLA ( 2 ) promoter . Positive_regulation NFKB1 IL1B 10438953 635171 Using EMSA , we show that stimulation with TNF-alpha or *induces* [NF-kappa B] DNA binding activity in human airway smooth muscle cells . Positive_regulation NFKB1 IL1B 10490923 645814 [NF-kappaB] activation in *response* to TNF-alpha , , phorbol ester , and H ( 2 ) O ( 2 ) was down-regulated by polaprezinc . Positive_regulation NFKB1 IL1B 10515888 652051 Phenylarsine oxide blocks induced *activation* of the nuclear transcription factor [NF-kappaB] , inhibits proliferation , and induces apoptosis of acute myelogenous leukemia cells . Positive_regulation NFKB1 IL1B 10515888 652053 Because PAO inhibits activation of the transcription factor NF-kappaB and because NF-kappaB modulates an array of signals controlling cellular survival , proliferation , and cytokine production , we also studied the effect of PAO on NF-kappaB activation in AML cells and found that PAO suppressed the *induced* activation of [NF-kappaB] . Positive_regulation NFKB1 IL1B 10516205 652290 TNF-alpha enhanced MAP kinase activity was associated with an increase in *stimulated* [NF-kappaB] activity . Positive_regulation NFKB1 IL1B 10544256 564100 Using electrophoretic mobility shift assays , we found that not only tumour necrosis factor-alpha (TNF-alpha) but also and parathyroid hormone (PTH) *caused* dose and time related increases in [nuclear factor kappaB (NF-kappaB)-DNA] binding in Saos-2 human osteoblastic ( hOB ) cells . Positive_regulation NFKB1 IL1B 10564154 567137 In contrast to NAC , the metal chelators pyrrolidine dithiocarbamate and diethyldithiocarbamate attenuated *induced* [NF-kappaB] activation but had no effect on intracellular sulfhydryl content . Positive_regulation NFKB1 IL1B 10594073 573023 An essential *role* of in mediating [NF-kappaB] activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia . Positive_regulation NFKB1 IL1B 10605929 655651 We have studied whether ROIs played any role in [NF-kappaB] *induction* by in different cell types . Positive_regulation NFKB1 IL1B 10605929 655653 Interestingly , transfection of epithelial cells with the 5-LOX and 5-LOX activating protein expression vectors restored ROI production and ROI dependent [NF-kappaB] activation in *response* to . Positive_regulation NFKB1 IL1B 10605929 655657 Our data thus indicate that ROIs are cell type-specific second messengers for [NF-kappaB] *induction* by . Positive_regulation NFKB1 IL1B 10617676 657181 *caused* the translocation of p65 [NF-kappaB] from cytosol to the nucleus as well as the degradation of IkappaB-alpha in cytosol . Positive_regulation NFKB1 IL1B 10629862 576465 We also found in IL-1 beta induced CINC expression using cultured C6 glioma cells , the transient translocation of [NF-kappa B] in *response* to is partly dependent on transient proteasome activation . Positive_regulation NFKB1 IL1B 10638662 660326 *induction* of [NF-kappaB] activation in human intestinal epithelial cells is independent of oxyradical signaling . Positive_regulation NFKB1 IL1B 10638662 660330 Similarly , scavenging of free radicals and oxidants by pyrrolidine dithiocarbamate and dimethyl sulfoxide did not block *induced* IkappaBalpha degradation and [NF-kappaB] activation . Positive_regulation NFKB1 IL1B 10638662 660333 Genistein , a nonspecific tyrosine kinase inhibitor , also had no effect on *mediated* effects on [NF-kappaB] . Positive_regulation NFKB1 IL1B 10644648 661126 These data suggest that constitutive [NF-kappaB] p65 protein synthesis is *regulated* by , particularly during pregnancy . Positive_regulation NFKB1 IL1B 10657679 664244 However , when the *dependent* induction of [NF-kappa B] was inhibited , the antiapoptotic effect of IL-1 beta was partially reversed , suggesting that NF-kappa B-mediated gene activation is part of the protective mechanism . Positive_regulation NFKB1 IL1B 10677576 668276 We then investigated the effects of transfection of monocytes with these oligonucleotides on *stimulated* IL-8 production , IL-8 mRNA expression , and [NF-kappaB] binding activity . Positive_regulation NFKB1 IL1B 10677576 668278 This single stranded oligonucleotide also inhibited *induced* translocation of [NF-kappaB] to the nucleus and reduced IL-8 mRNA expression . Positive_regulation NFKB1 IL1B 10707928 673457 In PANC-1 cells , and TNF-alpha *induced* a rapid activation of [nuclear factor (NF)-kappaB] , and TGF-beta1 enhanced this activation slightly . Positive_regulation NFKB1 IL1B 10766857 684568 Cellular differentiation causes a selective down-regulation of mediated [NF-kappaB] *activation* and IL-8 gene expression in intestinal epithelial cells . Positive_regulation NFKB1 IL1B 10766857 684570 In this study , we analyzed and characterized the effect of the differentiation of intestinal epithelial cells on mediated [NF-kappaB] *activation* and IL-8 gene expression . Positive_regulation NFKB1 IL1B 10766857 684573 We conclude that cellular differentiation of HT-29 cells selectively impairs the IL-1beta signaling pathway inhibiting both [NF-kappaB] and JNK activity in *response* to . Positive_regulation NFKB1 IL1B 10816656 580267 Furthermore , we determined the effect of alpha-MSH on the *induced* activation of the [nuclear factor kappa B (NF kappa B)] -- a major transcription factor for chemokine genes . Positive_regulation NFKB1 IL1B 10818069 693790 Addition of IL-1beta activated nuclear factor kappaB (NF-kappaB) in VSMCs , but sodium salicylate did not affect induced [NF-kappaB] *activation* . Positive_regulation NFKB1 IL1B 10843878 700352 ( 1 ng/ml ) *induced* marked and persistent [NF-kappaB] activation in VSMC that was maximal at 1 h and persisted for 3 days . Positive_regulation NFKB1 IL1B 10871193 706784 However , normal *mediated* translocation of [NF-kappaB] and induction of inducible nitric oxide synthase expression and nitric oxide production was severely impaired in the INS-1res cell lines , suggesting a mechanism for the IL-1beta resistance . Positive_regulation NFKB1 IL1B 10881930 709232 and TNF-alpha *induced* a rapid activation of [nuclear factor (NF)-kappaB] in PANC-1 cells , and the increase in chemokine mRNA expression correlated with NF-kappaB activation . Positive_regulation NFKB1 IL1B 10882729 730443 Neither receptor alone was able to mediate transcriptional activation of [NF-kappaB] in *response* to IL-1alpha , , or IL-18 . Positive_regulation NFKB1 IL1B 10884313 709543 However , pretreatment with oATP downregulated *activation* of [NF-kappaB] and AP-1 by or TNFalpha . Positive_regulation NFKB1 IL1B 11022128 738135 Using electrophoretic mobility shift assay ( EMSA ) , we show that *induced* [NFkappaB] activation in primary culture of mouse astrocytes is mediated by the interaction of this cytokine with the IL-1 type I receptor/IL-1 receptor accessory protein complex , as demonstrated by the ability of blocking monoclonal antibodies against these receptors to attenuate NFkappaB activation . Positive_regulation NFKB1 IL1B 11022128 738152 Furthermore , anti-inflammatory cytokines such as IL-4 and IL-10 that block induced [NFkappaB] *activation* also attenuate IL-1beta induced Akt phosphorylation , despite the fact that IL-4 and IL-10 in isolation induced Akt phosphorylation . Positive_regulation NFKB1 IL1B 11031204 740160 Electromobility gel shift and luciferase assays demonstrated that overexpression of IkappaBDeltaN inhibited [NF-kappaB] activation *induced* by TNF-alpha or . Positive_regulation NFKB1 IL1B 11067942 747604 These results indicate that sustained [NF-kappaB] activation in asthmatic bronchi is driven by granulocytes and is *mediated* by and TNF-alpha . Positive_regulation NFKB1 IL1B 11071643 748139 instead , *activated* [NF-kappaB] associated with 2 IL-6 responsive elements ( STAT3 binding site ) on the rat gamma fibrinogen promoter and blocked STAT3 binding to these regions . Positive_regulation NFKB1 IL1B 11076795 749215 *induces* eotaxin gene transcription in A549 airway epithelial cells through [NF-kappaB] . Positive_regulation NFKB1 IL1B 11087273 751210 HIV-gp120 enhanced p38 protein kinase activity was associated with an increase in *stimulated* [NF-kappaB] activity ( 184 +/- 12.7 vs. 92 +/- 10.7 optical units , IL-1beta + gp120 vs . IL-1beta , respectively ; n = 3 ) . Positive_regulation NFKB1 IL1B 11090945 754713 We demonstrated that [NF-kappaB] *activation* by follows three distinct cell-specific pathways . Positive_regulation NFKB1 IL1B 11104703 756489 However , pretreatment with the proteasome inhibitor MG132 under conditions that prevented the *dependent* activation of the nuclear factor [NF-kappaB] also blocked the inhibitory effect of IL-1beta on IL-6 activated STAT1 . Positive_regulation NFKB1 IL1B 11104703 756501 Taken together , these findings indicate that , by using a proteasome dependent mechanism , concomitantly *induces* [NF-kappaB] activation and dephosphorylates IL-6 activated STAT1 ; Positive_regulation NFKB1 IL1B 11114294 786556 Gel shift analysis showed that *activated* [NF-kappaB] in Calu-3 cells , and transfection experiments using p50 and RelA expressing vectors showed that exogenous transfected NF-kappaB subunits increased the concentration of CFTR mRNA . Positive_regulation NFKB1 IL1B 11114294 786558 Gel shift analysis with antibody supershifting also showed that *caused* the binding of [NF-kappaB] to a kappaB-like response element at position -1103 to -1093 in the CFTR 5'-flanking region . Positive_regulation NFKB1 IL1B 11115778 757918 Electrophoretic mobility shift assays ( EMSAs ) revealed that and TNF alpha *activate* the transcription factor [NF kappa B] in reaggregates of rat anterior pituitaries and in TtT/Gf cells cultured alone or cocultured with GH3 cells . Positive_regulation NFKB1 IL1B 11191283 761383 The acid sphingomyelinase inhibitor SR33557 counteracts TNF-alpha mediated potentiation of induced [NF-kappaB] *activation* in the insulin producing cell line Rinm5F . Positive_regulation NFKB1 IL1B 11191283 761390 TNF-alpha activated NF-kappaB in gel shift experiments without inducing iNOS -- as assessed by nitrite formation -- whereas *stimulated* both [NF-kappaB] activation and iNOS induction . Positive_regulation NFKB1 IL1B 11274209 819039 This regulation of NF-kappaB activation by PKCdelta was specific only for TNFalpha signaling , since lipopolysaccharide- or *induced* [NF-kappaB] activation and IkappaBalpha degradation were not inhibited by rottlerin . Positive_regulation NFKB1 IL1B 11275558 797834 Gel shift assay and an immunocytochemical study showed that N2733 inhibited *induced* [NF-kappaB] activation and its nuclear translocation . Positive_regulation NFKB1 IL1B 11275558 797842 Our results suggest that the inhibitory action of N2733 toward *induced* [NF-kappaB] activation and iNOS expression is due to its blockade of the upstream signal ( s ) leading to IKK-alpha activation , and subsequent phosphorylation and degradation of IkappaB-alpha in rat VSMCs . Positive_regulation NFKB1 IL1B 11385114 821631 In cells obtained before labour , in which NF-kappaB activity is low , increasing the concentration of PR represses NF-kappaB dependent transcription , while stimulation with both *increases* [NF-kappaB] activity and represses PR activity . Positive_regulation NFKB1 IL1B 11390371 842544 Functional coupling between secretory and cytosolic phospholipase A2 modulates tumor necrosis factor-alpha- and *induced* [NF-kappa B] activation . Positive_regulation NFKB1 IL1B 11390371 842551 We have previously shown that both secretory and cytosolic phospholipase A(2) ( PLA(2) ) are involved in TNF-alpha- and *induced* [NF-kappaB] activation . Positive_regulation NFKB1 IL1B 11390371 842560 We show that in addition to inhibitors of secretory and cytosolic PLA(2)s , 5-lipoxygenase inhibitors attenuate TNF-alpha- and *stimulated* [NF-kappaB] activation . Positive_regulation NFKB1 IL1B 11399097 823942 NIM had no effect on ( 1 ) *induced* increases in [NF-kappaB] or c/EBP signaling , or ( 2 ) human COX-2 promoter activity . Positive_regulation NFKB1 IL1B 11404398 825493 Using reporter constructs and electromobility shift assays , we found that cotreatment of astrocyte cultures with ATP ( 1-100 microm ) significantly potentiated mediated *activation* of [NF-kappaB] and AP-1 and that ATP alone activated AP-1 . Positive_regulation NFKB1 IL1B 11428868 831567 Furthermore , co-administration of U0126 and SB202190 did not affect the induced degradation of IkappaB-alpha and NF-kappaB nuclear translocation , indicating that [NF-kappaB] is *activated* by and TNF-alpha independently of activation of MEK/MAPK and p38 pathways in hRPE cells . Positive_regulation NFKB1 IL1B 11445585 860046 In this study , we have further investigated the mechanisms of PLA(2) modulated NF-kappaB activation with respect to specific kinases involved in *stimulated* cPLA(2) phosphorylation and [NF-kappaB] activation . Positive_regulation NFKB1 IL1B 11445585 860052 The protein kinase C ( PKC ) inhibitors RO 31-8220 , Gö 6976 , and a pseudosubstrate peptide inhibitor of atypical PKCs attenuated arachidonic acid release , cPLA(2) phosphorylation , and [NF-kappaB] activation *induced* by TNF-alpha or , thus indicating atypical PKCs in cPLA(2) regulation and transcription factor activation . Positive_regulation NFKB1 IL1B 11445585 860070 Hence , lambda/iotaPKC regulates snpPLA ( 2 ) /LTB ( 4 ) -mediated cPLA(2) activation , cellular arachidonic acid release , and [NF-kappaB] activation *induced* by TNF-alpha and . Positive_regulation NFKB1 IL1B 11466367 839953 It is shown that IL-1beta prevents STAT3 binding to the two STAT3-responsive sites within the alpha(2)-macroglobulin promoter by association of *activated* [NF-kappaB] to this region . Positive_regulation NFKB1 IL1B 11466367 839955 The observation that inhibition of IL-6 induced transcriptional activation of this promoter by IL-1beta is reversed by cotransfection with I-kappaBalpha provides evidence that [NF-kappaB] *activation* by is responsible for inhibition of IL-6 mediated trans activation of the alpha(2)-macroglobulin gene . Positive_regulation NFKB1 IL1B 11466367 839963 Additional data are provided indicating that the *activation* of [NF-kappaB] by is also responsible for the inhibition of other IL-6-inducible genes , such as the alpha(1)-antichymotrypsin gene as well as the suppressor of cytokine signaling 3 gene , suggesting a more general relevance of this mechanism for transcriptional regulation . Positive_regulation NFKB1 IL1B 11470788 860372 IKKgamma/NEMO is an essential regulatory component of the IkappaB kinase complex that is required for [NF-kappaB] activation in *response* to various stimuli including tumor necrosis factor-alpha and . Positive_regulation NFKB1 IL1B 11474579 841776 The -1034/+88 bp iNOS promoter was strongly *induced* by , the regulatory elements for such induction being localized downstream of -205 bp. Cotransfection experiments with NF-kappaB isoforms , IkappaB isoforms , and IKK mutants suggested that the NF-kappaB site at -115/-106 bp is important , but not sufficient , for induction of iNOS promoter and that the role of [NF-kappaB] is partially independent of its binding site . Positive_regulation NFKB1 IL1B 11502752 868387 The results showed that Smad3 and Smad4 , but not Smad1 or Smad2 , mimicked the inhibitory effect of TGF-beta and abrogated *induced* stimulation of MMP-1 promoter activity and [NFkappaB-specific] gene transcription in dermal fibroblasts . Positive_regulation NFKB1 IL1B 11536016 854883 Our data suggest that Pseudo-ICE and ICEBERG are intracellular regulators of caspase-1 activation and could play a role in the regulation of secretion and [NF-kappaB] *activation* during the pro-inflammatory cytokine response . Positive_regulation NFKB1 IL1B 11574401 864926 The transcription factor [nuclear factor-kappaB (NF-kappaB)] is *activated* by , and its activity promotes the expression of several beta-cell genes , including pro- and anti-apoptotic genes . Positive_regulation NFKB1 IL1B 11575451 865001 Extracellular stimuli , notably and tumor necrosis factor alpha (TNF-alpha) *activate* [NF-kappaB] nuclear translocation via IkappaB phosphorylation and degradation . Positive_regulation NFKB1 IL1B 11575451 865004 These data indicate that inhibition of *induced* [NF-kappaB] activation by butyrate does not require an intact IkappaB alpha protein . Positive_regulation NFKB1 IL1B 11583588 865681 Functional analysis of the interleukin-1-receptor associated kinase ( IRAK-1 ) in *stimulated* [nuclear factor kappa B (NF-kappa B)] pathway activation : IRAK-1 associates with the NF-kappa B essential modulator (NEMO) upon receptor stimulation . Positive_regulation NFKB1 IL1B 11585641 866128 The data suggest that hypoxia/reoxygenation induced up-regulation of IL-1beta and IL-8 in human astrocytes has two components , a NF-kappaB independent up-regulation during hypoxia , followed by amplification through autocrine *induced* [NF-kappaB] activation during reoxygenation . Positive_regulation NFKB1 IL1B 11641387 872127 E2 treatment of VSM cells from aged female rats inhibited both constitutive and *stimulated* [NF-kappaB] activation . Positive_regulation NFKB1 IL1B 11641387 872130 In conclusion , our data demonstrate that constitutive and *stimulated* [NF-kappaB] activation is increased in VSM cells from aged female rats due to loss of E2 and this can be restored back to normal levels by ER-alpha gene transfer and E2 treatment . Positive_regulation NFKB1 IL1B 11672585 872563 stimulation *caused* activation of [nuclear factor-kappaB (NF-kappaB)] and expression of cyclooxygenase-2 (COX-2) mRNA and protein , which were inhibited by daunorubicin . Positive_regulation NFKB1 IL1B 11698503 878187 In naive cells , LPS , TNF-alpha , and *induced* IkappaBalpha degradation , kinase phosphorylation , and [NF-kappaB] DNA binding . Positive_regulation NFKB1 IL1B 11703098 878873 While the Raf-1 activation induces a modest IkappaB degradation by enhancing the basal IkappaB kinase activity , it contradictorily suppresses the proinflammatory cytokine inducible IkappaB kinase complex , leading to an inhibition of TNF-alpha- and *induced* [NF-kappaB] activation . Positive_regulation NFKB1 IL1B 11730360 884946 We found that both and TNF-alpha could independently *activate* cytosolic [NF-kappaB] , direct its translocation into the nucleus , and induce iNOS monomer synthesis . Positive_regulation NFKB1 IL1B 11742864 887438 *induced* a rapid and transient activation of [nuclear factor-kappaB (NF-kappaB)] , followed by a prolonged activation of NF-kappaB that was required to induce iNOS expression . Positive_regulation NFKB1 IL1B 11742864 887441 Transfection with antisense , but not sense , phosphorothioate modified oligodeoxynucleotides directed toward ERK also reduced induced prolonged [NF-kappaB] *activation* and iNOS expression . Positive_regulation NFKB1 IL1B 11742864 887448 These data suggest that ERK activity is *required* for persistent [NF-kappaB] activation by that is necessary for iNOS gene expression . Positive_regulation NFKB1 IL1B 11755929 898991 Both and TNF-alpha *stimulated* [NF-kappaB] activity , iNOS mRNA and protein expression with massive nitrite/nitrate ( NOx ) production in rat VSMCs . Positive_regulation NFKB1 IL1B 11774033 890561 Inhibition of IL-6 activity attenuated *induced* promatrilysin , but not [NFkappaB] transactivation activity indicating that IL-6 acts downstream of NFkappaB in potentiation of IL-1beta mediated promatrilysin expression . Positive_regulation NFKB1 IL1B 11795669 901984 Additionally , , but not CM-IL8 , *promoted* the activation of [NF-kappaB] , which has anti-apoptotic activity . Positive_regulation NFKB1 IL1B 11828002 909561 FADD ( -/- ) MEFs were also resistant to [NF-kappa B] activation *induced* by . Positive_regulation NFKB1 IL1B 11828002 909564 Together , these data indicate that FADD negatively regulates LPS- and *induced* [NF-kappa B] activation and that this regulation occurs upstream of I kappa B degradation . Positive_regulation NFKB1 IL1B 11834481 911046 However , and phorbol 12-myristate 13-acetate also *activated* [NF-kappaB] but did not evoke TNF-alpha expression , revealing that this factor is not sufficient for cytokine production . Positive_regulation NFKB1 IL1B 11912207 944618 In both cultured rat cerebellar granule cells and mouse hippocampal slices , we examined [NF-kappaB/Rel] *activation* induced by two opposing modulators of cell viability : 1 ) , which promotes neuron survival and 2 ) glutamate , which can elicit toxicity . Positive_regulation NFKB1 IL1B 11976320 953883 In this study , we show the roles that CaMKK and Akt play in regulating *induced* [NF-kappaB] signaling . Positive_regulation NFKB1 IL1B 11976320 953901 In human embryonic kidney 293 cells , *induces* IkappaB kinase beta (IKKbeta) activation , IkappaBalpha degradation , [NF-kappaB] transactivation , and weak Akt activation . Positive_regulation NFKB1 IL1B 11976320 953914 A CaMKK inhibitor ( KN-93 ) and phosphatidylinositol 3-kinase inhibitors ( wortmannin and LY294002 ) do not inhibit induced [NF-kappaB] *activation* . Positive_regulation NFKB1 IL1B 11976320 953934 However , *induced* [NF-kappaB] activity is attenuated by increased intracellular calcium in response to ionomycin , UTP , or thapsigargin or by overexpression of CaMKKc and/or Akt . Positive_regulation NFKB1 IL1B 11976320 953987 We have also identified a novel interaction between CaMKK stimulated Akt and interleukin-1 receptor associated kinase 1 ( IRAK1 ) , which plays a key role in induced [NF-kappaB] *activation* . Positive_regulation NFKB1 IL1B 11976320 954022 Taken together , these results indicate a novel regulatory mechanism for IL-1beta signaling and suggest that CaMKK dependent Akt activation inhibits *induced* [NF-kappaB] activation through interference with the coupling of IRAK1 to MyD88 . Positive_regulation NFKB1 IL1B 11996950 939211 In addition , *induced* [NF-kappaB] activation in VSMC , an effect that was increased by the addition of beta-VLDL . Positive_regulation NFKB1 IL1B 12031964 947861 Electromobility shift assays demonstrated that sodium salicylate inhibits *induced* [nuclear factor-kappaB (NF-kappaB)] activation . Positive_regulation NFKB1 IL1B 12031968 947869 Furthermore , cFLIP overexpression increased the basal and *mediated* transcriptional activity of [nuclear factor (NF)-kappaB] , whereas it did not change cytokine induced inducible nitric oxide synthase gene transcription and nitric oxide secretion . Positive_regulation NFKB1 IL1B 12034025 948187 Treatment of melanoma cells with capsaicin inhibited activation of constitutive and *induced* [NF-kappaB] , but not AP-1 , leading to inhibition of IL-8 expression . Positive_regulation NFKB1 IL1B 12034569 948756 *induces* DNA binding of both [nuclear factor kappaB (NF-kappaB)] and CAATT-enhancer binding protein (C/EBP) , and activation of p38 mitogen activated protein kinase in both subpopulations . Positive_regulation NFKB1 IL1B 12055073 951612 [NF-kappaB] *induced* by inhibits elastin transcription and myofibroblast phenotype . Positive_regulation NFKB1 IL1B 12055073 951624 These results indicate that *activates* the nuclear localization of [NF-kappaB] that subsequently interacts with Sp1 to downregulate elastin transcription and expression of the myofibroblast phenotype . Positive_regulation NFKB1 IL1B 12126643 966028 Electrophoretic mobility shift assays confirmed that *increased* AP-1 and [NF-kappaB] DNA binding activities in a time dependent manner . Positive_regulation NFKB1 IL1B 12131776 966845 and TNF-alpha *increased* the [nuclear factor-kappa B (NF-kappa B)-specific] and activator protein-1-specific DNA binding activity , whereas the NF-IL6 activity was not altered . Positive_regulation NFKB1 IL1B 12133394 966935 [NF-kappa B] in the retina can be *activated* by intraocular . Positive_regulation NFKB1 IL1B 12167775 973505 We report that 17beta-estradiol ( E ( 2 ) ) , but not the alpha-enantiomer , inhibited the basal and *mediated* expression of the intercellular adhesion molecule type 1 ( ICAM1 ) and [NFkappaB] activation , in cultured brain endothelial cells . Positive_regulation NFKB1 IL1B 12193729 981514 TAT-srIkappaBalpha , when exogenously added to HeLa cells , inhibited in a dose dependent manner TNF-alpha- or *induced* [NF-kappaB] activation and binding of NF-kappaB to its consensus DNA sequence . Positive_regulation NFKB1 IL1B 12219013 986612 The 2 groups of mice were analyzed for serum levels of interferon-gamma , tumor necrosis factor-alpha , and as well as *activation* of [NFkappaB] and STAT1 , 2 proinflammatory transcription factors . Positive_regulation NFKB1 IL1B 12220616 986966 *induced* activation of [NF-kappaB] correlated with the degradation of IkappaB-alpha in TSMCs . Positive_regulation NFKB1 IL1B 12220616 986970 IL-1beta induced COX-2 expression and PGE ( 2 ) synthesis were completely inhibited by PD98059 ( an inhibitor of MEK1/2 ) and SB203580 ( an inhibitor of p38 inhibitor ) , but these two inhibitors had no effect on *induced* [NF-kappaB] activation , indicating that activation of p42/44 and p38 MAPK and NF-kappaB signalling pathways were independently required for these responses . Positive_regulation NFKB1 IL1B 12237169 989142 Addition of IL-1beta activated NF-kappaB in cardiac myocytes , while CRP did not affect induced [NF-kappaB] *activation* . Positive_regulation NFKB1 IL1B 12241537 989694 *increased* [NF-kappaB] DNA binding activity , IL-6 mRNA levels and IL-6 production . Positive_regulation NFKB1 IL1B 12356282 993914 Treatment of cells with byakangelicol ( 50 microM ) or pyrrolidine dithiocarbamate ( PDTC ; 50 microM ) partially inhibited *induced* degradation of IkappaB-alpha in the cytosol , translocation of p65 [NF-kappaB] from the cytosol to the nucleus and the NF-kappaB-specific DNA-protein complex formation . Positive_regulation NFKB1 IL1B 12399621 1009122 SIN-1 dose dependently inhibited the TNF-alpha- or *induced* [NF-kappaB] binding activity and suppressed the TNF-alpha induced degradation of IkappaB-alpha . Positive_regulation NFKB1 IL1B 12417253 1012961 Treatment of cells with sphondin ( 50 microM ) or the NF-kappaB inhibitor , PDTC ( 50 microM ) partially inhibited *induced* degradation of IkappaB-alpha in the cytosol and translocation of p65 [NF-kappaB] from the cytosol to the nucleus . Positive_regulation NFKB1 IL1B 12417253 1012964 Furthermore , *induced* [NF-kappaB-specific] DNA-protein complex formation in the nucleus was partially inhibited by sphondin ( 50 microM ) or PDTC ( 50 microM ) . Positive_regulation NFKB1 IL1B 12421347 1013467 In comparison , *induced* the release of PGE2 , IL-6 and activated [NF-kappaB] , p38 , JNK and ERK1/2 in mixed glial cultures , but failed to induce any of these responses in microglial cell cultures . Positive_regulation NFKB1 IL1B 12426209 1014372 However , either PDGF or EGF markedly enhanced *induced* persistent [NF-kappaB] activation and iNOS expression but did not affect the early and transient NF-kappaB activation . Positive_regulation NFKB1 IL1B 12426209 1014380 Inhibition of ERK phosphorylation with selective inhibitors ( PD98059 or U0126 ) attenuated *induced* persistent [NF-kappaB] activation and iNOS expression in either the absence or presence of the growth factors . Positive_regulation NFKB1 IL1B 12485902 1025164 Thalidomide inhibited *induced* [NFkappaB] transcriptional activation and IL-8 production in Caco-2 colon cancer cells . Positive_regulation NFKB1 IL1B 12509805 1038773 Finally , and TNF-alpha *induced* degradation of NF-kappaB 's bound inhibitory protein , IkappaB-alpha , leading to translocation of [NF-kappaB] into the nucleus . Positive_regulation NFKB1 IL1B 12517972 1039416 Unlike IL-1beta , NS-398 and Cig did not cause NF-kappaB ( p65 ) nuclear translocation , nor did they further enhance *induced* [NF-kappaB] translocation , but they stimulated PPARgamma translocation . Positive_regulation NFKB1 IL1B 12528110 1048606 Activation of [NF-kappa B] was *induced* by , but not by MIF . Positive_regulation NFKB1 IL1B 12528110 1048610 Anti-MIF mAb had no effect on *induced* [NF-kappa B] nuclear translocation . Positive_regulation NFKB1 IL1B 12588520 1059441 Activation of [NF kappa B] in *response* to was no longer apparent in IL-1RI knockout mice , confirming that this receptor is essential for the transduction of IL-1 signal in the pituitary , but remained after LPS treatment . Positive_regulation NFKB1 IL1B 12594282 1060898 In contrast , *induced* [NF-kappa B] activity and I kappa B alpha degradation were not affected by BMP-7 . Positive_regulation NFKB1 IL1B 12594338 1064341 To further substantiate that the observed [NF-kappa B-dependent] *induction* of the human NK-1R gene is regulated via a transcriptional event through this NF-kappa B site on the NK-1R gene promoter , we transfected THP-1 cells with a luciferase promoter-reporter construct containing the 5 ' promoter region of the human NK-1R gene . Positive_regulation NFKB1 IL1B 12603824 1062512 Caffeic acid phenethyl ester , a potent and specific inhibitor of activation of NF-kappaB , not only blocked *induced* activation of the [NF-kappaB] promoter but also decreased IL-1beta induced MIP-1alpha and -1beta expression in NT2-N cells . Positive_regulation NFKB1 IL1B 12609991 1085313 consistently , LPS and *led* to activation of [NF kappa B] in entorhinal cortex . Positive_regulation NFKB1 IL1B 12670873 1080135 This leads to sustained suppression of *induced* [NF-kappaB] transcriptional regulation of proinflammatory genes . Positive_regulation NFKB1 IL1B 12681956 1077501 Glucosamine inhibits induced [NFkappaB] *activation* in human osteoarthritic chondrocytes . Positive_regulation NFKB1 IL1B 12689943 1106077 Resveratrol blocks *induced* activation of the nuclear transcription factor [NF-kappaB] , inhibits proliferation , causes S-phase arrest , and induces apoptosis of acute myeloid leukemia cells . Positive_regulation NFKB1 IL1B 12689943 1106079 It also suppressed the *induced* activation of transcription factor [nuclear factor kappaB (NF-kappaB)] , which modulates an array of signals controlling cellular survival , proliferation , and cytokine production . Positive_regulation NFKB1 IL1B 12743110 1088391 We show that the *induced* accumulation of nuclear [NFkappaB] in human umbilical vein endothelial cell monolayers is dramatically reduced when polymorphonuclear leukocytes ( PMN ) are allowed to migrate across these monolayers . Positive_regulation NFKB1 IL1B 12743110 1088398 Furthermore , cross linking of platelet-endothelial cell adhesion molecule-1 ( PECAM-1 ) , but not intercellular adhesion molecule-1 , reduces human umbilical vein endothelial cell nuclear [NFkappaB] *induced* by . Positive_regulation NFKB1 IL1B 12744771 1088520 U937 membranes , as well as and TNF-alpha , *induced* nuclear translocation of [NF-kappaB] . Positive_regulation NFKB1 IL1B 12745547 1088616 Finally , when the cells were exposed to Dex ( 1 microM ) prior to stimulation with IL-1beta ( 20 ng/ml ) , Dex was efficient in preventing *induced* [NF-kappaB] activation . Positive_regulation NFKB1 IL1B 12745547 1088618 Our results indicate that , in CCRF-CEM cells , Dex prevents [NF-kappaB] activation , *induced* by , by a mechanism that involves the upregulation of IkappaB-alpha synthesis , and that depends on the early and transient activation of NF-kappaB . Positive_regulation NFKB1 IL1B 12746898 1088816 Transient transfection experiments and EMSAs showed that induction of ESE-1 gene expression by *requires* activation of [NF-kappaB] and binding of p50 and p65 family members to the NF-kappaB site in the ESE-1 promoter . Positive_regulation NFKB1 IL1B 12761333 1091494 Both of these agents also reduced the activation of [NF-kappaB] *induced* by LPS , tumor necrosis factor-alpha and in smooth muscle cells . Positive_regulation NFKB1 IL1B 12799018 1100967 induced release of IL-6 and *activated* [NFkappaB] , p38 , JNK and ERK1/2 in mixed glial cultures , which was completely abolished in the presence of IL-1 receptor antagonist (IL-1ra) . Positive_regulation NFKB1 IL1B 12839952 1108182 Electrophoretic mobility shift assay on nuclear extracts demonstrated that *induced* [NF-kappa B] DNA binding activity in HT-29 cells , and the activated NF-kappa B complex was eliminated after treatment with an inhibitor of NF-kappa B . Positive_regulation NFKB1 IL1B 12839952 1108186 Supershift assay indicated that the two NF-kappa B subunits , p65 and p50 , were involved in *activation* of [NF-kappa B] complex by stimulation . Positive_regulation NFKB1 IL1B 12860295 1111266 Here we demonstrate that *induces* nuclear translocation of [NF-kappaB] in human umbilical vein endothelial cells ( HUVEC ) followed by induction of cell surface expression of E-selectin , ICAM-1 and VCAM-1 , and subsequently augments adhesion of cancer cells expressing sialyl Lewis antigen , a ligand of E-selectin . Positive_regulation NFKB1 IL1B 12860389 1111469 *dependent* activation of [NF-kappaB] mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase . Positive_regulation NFKB1 IL1B 12873450 1114305 The objective of the study was to investigate the effects of baicalin , baicalein , and wogonin ( plant flavonoids ) on interleukin-6 (IL-6) and interleukin-8 (IL-8) protein production , mRNA expression , and [nuclear factor-kappaB (NF-kappaB)] binding activities *induced* by in human retinal pigment epithelial cell line ( ARPE-19 ) cells . Positive_regulation NFKB1 IL1B 12923200 1151283 In addition , in neural cells in culture , this lipid messenger also inhibited both *induced* [NFkappaB] activation and cyclooxygenase-2 expression . Positive_regulation NFKB1 IL1B 14527176 1148351 Rhein inhibits *induced* activation of MEK/ERK pathway and DNA binding of [NF-kappa B] and AP-1 in chondrocytes cultured in hypoxia : a potential mechanism for its disease modifying effect in osteoarthritis . Positive_regulation NFKB1 IL1B 14576508 1156486 Addition of IL-1beta activated nuclear factor-kappaB (NFkappaB) in VSMCs , whereas CRP did not affect *induced* [NFkappaB] activation . Positive_regulation NFKB1 IL1B 14581482 1186911 Without ERK activation , *induces* only acute and transient [NF-kappaB] activation . Positive_regulation NFKB1 IL1B 14600157 1187538 [NF-kappaB] activation *induced* by tumor necrosis factor (TNF)-alpha , , and lipopolysaccharide was also inhibited by FAF1 overexpression . Positive_regulation NFKB1 IL1B 14664905 1177725 These data indicate that therapeutic concentrations of acetaminophen induce an inhibition of *dependent* [NF-kappaB] nuclear translocation . Positive_regulation NFKB1 IL1B 14679201 1211258 Similarly , NO attenuates *induced* [NF-kappaB] activation . Positive_regulation NFKB1 IL1B 14691386 1179914 Stimulation of hepatocytes with *caused* a higher activation of IL-1 associated kinase , extracellular receptor activated kinases 1 and 2 , and [nuclear factor-kappaB (NF-kappaB)] in hepatocytes from alcohol fed animals than from controls . Positive_regulation NFKB1 IL1B 14691386 1179916 Our results suggest the participation of the extracellular signal regulated kinase ( ERK ) 1/2 pathway in ethanol induced NF-kappaB activation , because treatment with PD-98059 , an ERK1/2 inhibitor , partially suppressed *induced* [NF-kappaB] expression . Positive_regulation NFKB1 IL1B 14708613 1181165 In normal human keratinocytes PPAR agonists neither impaired IL-1beta induced translocation of p65 nor *induced* [NF-kappaB] DNA binding . Positive_regulation NFKB1 IL1B 14746807 1182114 Investigation of the mechanism involved in MIP-1beta induction by IL-1beta showed that *activated* the [nuclear factor kappa B (NF-kappaB)] promoter in Huh7 cells . Positive_regulation NFKB1 IL1B 14746807 1182117 In addition , caffeic acid phenethyl ester ( CAPE ) , a specific inhibitor of the activation of NF-kappaB , not only abolished *mediated* [NF-kappaB] promoter activation , but also blocked IL-1beta induced MIP-1beta expression . Positive_regulation NFKB1 IL1B 14985981 1236666 The *activation* of [NF-kappaB] by was maximal at 20 min and declined thereafter . Positive_regulation NFKB1 IL1B 15001568 1236965 The present study examined the effect of angiotensin II on induced [NF-kappaB] *activation* and the subsequent expression of inducible NO synthase (iNOS) and vascular cell adhesion molecule-1 ( VCAM-1 ) in cultured rat vascular smooth muscle cells . Positive_regulation NFKB1 IL1B 15001568 1236971 The inhibitory effect of angiotensin II on iNOS expression was associated with a down-regulation of the sustained *activation* of extracellular signal regulated kinase ( ERK ) and [NF-kappaB] by , whereas the effect on VCAM-1 was independent of ERK activation . Positive_regulation NFKB1 IL1B 15039285 1265151 Compared with free form , fibrinogen bound *stimulated* increased activation of endothelial cell [nuclear factor kappaB (NF-kappaB)] , monocyte chemoattractant protein-1 ( MCP-1 ) secretion , and nitric oxide ( NO ) synthesis . Positive_regulation NFKB1 IL1B 15039421 1251251 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of , and RIP2 dependent *activation* of [NF-kappaB] and p38 MAPK mediated by the caspase recruitment domain . Positive_regulation NFKB1 IL1B 15044702 1228281 Expression of in AF macrophages and *activation* of [NF-kappaB] in the maternal uterus increased with the gestational increase in SP-A . Positive_regulation NFKB1 IL1B 15044702 1228283 We propose that augmented production of SP-A by the fetal lung near term causes activation and migration of fetal AF macrophages to the maternal uterus , where increased production of *activates* [NF-kappaB] , leading to labor . Positive_regulation NFKB1 IL1B 15056867 1230153 It was found that overexpression of Tom1 suppresses activation of transcription factors , [NF-kappaB] and AP-1 , *induced* by either or tumor necrosis factor (TNF)-alpha and that the VHS domain of Tom1 is indispensable for its suppressive activity . Positive_regulation NFKB1 IL1B 15067222 1231909 Furthermore , *induced* activation of [nuclear factor-kappaB (NF-kappaB)] was inversely correlated with the degradation of IkappaB-alpha in HTSMCs . Positive_regulation NFKB1 IL1B 15191916 1280940 Dexamethasone , a glucocorticoid , inhibited *induced* nuclear translocation of [NF-kappaB] and also the secretion of IL-13 from mast cells . Positive_regulation NFKB1 IL1B 15194434 1259767 We found that differentiated Caco-2 and HT29-D4 cells were responsive to both cytokines TNFalpha- and mediated *activation* of [NF-kappaB] but that undifferentiated HT29-D4 cells were unresponsive to IL-1beta . Positive_regulation NFKB1 IL1B 15194434 1259769 Finally , it appeared that in polarized HT29-D4 cells , the *induced* translocation of [NF-kappaB] was connected to PKCdelta translocation . Positive_regulation NFKB1 IL1B 15208668 1281357 Electrophoretic mobility shift assay confirmed that *increased* the DNA binding activity of AP-1 and [NF-kappaB] . Positive_regulation NFKB1 IL1B 15229109 1301846 Human breast milk suppresses the transcriptional regulation of *induced* [NF-kappaB] signaling in human intestinal cells . Positive_regulation NFKB1 IL1B 15240151 1270120 Interestingly , *induced* [nuclear factor-kappaB (NF-kappaB)] activation in A549 cells , which was shown by increased nuclear translocation of p65 NF-kappaB and degradation of IkappaB-alpha . Positive_regulation NFKB1 IL1B 15240151 1270123 Specifically , *induced* nuclear translocation of [NF-kappaB] was in part attenuated by LY294002 , but not by GF109203X , SB203580 , and SP600125 , suggesting PI3K dependent nuclear translocation of NF-kappaB in response to IL-1beta . Positive_regulation NFKB1 IL1B 15269222 1290335 Inhibition of ERK1/2 , JNKs , and PKC-alpha/beta1 had no effect on NF-kappaB activation , whereas inhibition of PKC-theta and PKC-zeta inhibited *stimulated* activation of [NF-kappaB] . Positive_regulation NFKB1 IL1B 15271652 1333120 *stimulated* the degradation of IkappaB and the activation of [NF-kappaB] but had no effect on iNOS induction . Positive_regulation NFKB1 IL1B 15292915 1278945 Preincubation with transport peptide-PNA-NFkappaB decoy ( 1 microM , 1 h ) blocked *induced* [NFkappaB] binding activity and significantly reduced the IL-6 mRNA expression . Positive_regulation NFKB1 IL1B 15341531 1291769 Consistently , *stimulated* translocation of [NF-kappaB] into the nucleus and degradation of inhibitory kappa B-alpha ( IkappaB-alpha ) was revealed by western blotting and immunofluorescence staining , which was blocked by helenalin , but not by U0126 , SB202190 , or SP600125 . Positive_regulation NFKB1 IL1B 15373762 1297878 *induced* expression of phosphorylated IkappaB and the activation of [NF-kappaB] . Positive_regulation NFKB1 IL1B 15389584 1354332 Consistently , *stimulated* translocation of [NF-kappaB] into the nucleus and degradation of IkappaB-alpha which was blocked by helenalin , U0126 , or SP600125 . Positive_regulation NFKB1 IL1B 15390113 1304803 Caffeic acid phenethyl ester ( CAPE ) , a specific inhibitor of NF-kappaB activation , not only abrogated induced [NF-kappaB] promoter *activation* , but also blocked IL-1beta mediated induction of NK-1R gene expression . Positive_regulation NFKB1 IL1B 15450943 1300782 Epicatechin significantly reduced IL-1beta induced nitrite production , iNOS protein and mRNA expressions , and it also inhibited induced IkappaBalpha protein degradation , [NF-kappaB] *activation* , and iNOS promoter activity . Positive_regulation NFKB1 IL1B 15456740 1342014 However , H2O2 , tumor necrosis factor-alpha (TNF-alpha) , and significantly *increased* [NF-kappaB] activation and expression of IL-8 compared with control cells . Positive_regulation NFKB1 IL1B 15480896 1320315 *mediated* [NFkappaB] was completely inhibited in the presence of lactacystin , a potent inhibitor of NFkappaB . Positive_regulation NFKB1 IL1B 15489374 1359436 As expected , *stimulated* translocation of [NF-kappaB] into the nucleus and degradation of IkappaB-alpha were blocked by helenalin but not by U0126 , SB-202190 , or SP-600125 . Positive_regulation NFKB1 IL1B 15529376 1335743 CTS of low magnitudes ( 4-8 % equibiaxial strain ) was a potent inhibitor of *dependent* [NF-kappaB] nuclear translocation . Positive_regulation NFKB1 IL1B 15529381 1335748 *induced* DNA binding of [NF-kappaB] and AP-1 was significantly higher in hypoxic and reoxygenated cultures than in normoxia . Positive_regulation NFKB1 IL1B 15539433 1380513 Moreover , individual boswellic acids were demonstrated to increase the basal and *stimulated* [NF-kappaB] activity in intestinal epithelial cells in vitro as well as reverse proliferative effects of IL-1beta . Positive_regulation NFKB1 IL1B 15550384 1360975 l-Mimosine did not affect IKK and [NF-kappaB] *activation* by . Positive_regulation NFKB1 IL1B 15662752 1350349 It became known , that oxidized LDL can inhibit LPS induced binding of the NF-kappaB to DNA and the subsequent expression of TNF-alpha and in macrophages as well as oxidized LDL modulates *activation* of [NF-kappaB] in mononuclear phagocytes by altering the degradation of I-kappaBs . Positive_regulation NFKB1 IL1B 15695308 1382613 A77 1726 inhibited IL-1beta induced p38 and c-Jun N-terminal kinase 1/2 ( JNK1/2 ) activation , whereas A77 1726 did not affect *induced* [NF-kappaB] activation in hepatocytes . Positive_regulation NFKB1 IL1B 15739117 1383029 consistently *increased* islet [NFkappaB] activity and c-Myc , haeme-oxygenase 1 , inducible nitric oxide synthase (iNOS) , Fas , and inhibitor of NFkappaB alpha ( IkappaBalpha ) mRNA levels . Positive_regulation NFKB1 IL1B 15749024 1379455 Recombinant mouse *induced* strong activation of ERK1/2 , p38 , JNK and [NFkappa B] , and significant release of IL-6 and PGE2 , which was blocked by IL-1ra . Positive_regulation NFKB1 IL1B 15758944 1432211 Incubation of rat glioma cells with the NBD peptide blocked *induced* [NFkappaB] nuclear translocation . Positive_regulation NFKB1 IL1B 15758944 1432213 Treatment with NBD peptide completely abolished *induced* [NFkappaB] activation and Cox-2 synthesis in microvasculature . Positive_regulation NFKB1 IL1B 15758944 1432216 These findings strongly support the hypothesis that *induced* [NFkappaB] activation plays a major role in transmission of immune signals from the periphery to the brain . Positive_regulation NFKB1 IL1B 15820746 1393733 In the present study , using Caco-2 cells , a human enterocyte line , we demonstrate that rapidly *induces* the expression of the ASS gene at a transcriptional level through [NF-kappaB] activation . Positive_regulation NFKB1 IL1B 15821150 1417633 *induced* [nuclear factor-kappaB (NF-kappaB)] DNA binding activity was significantly inhibited by 15d-PGJ ( 2 ) ( 10 microM ) and GW501516 ( 1 microM ) but increased with 10 microM rosiglitazone . Positive_regulation NFKB1 IL1B 15900319 1451777 To assess whether this action is mediated by NFkappaB activation , rats were injected into the lateral ventricle of the brain with a specific inhibitor of NFkappaB activation , the NEMO Binding Domain (NBD) peptide that has been shown previously to abolish completely *induced* [NFkappaB] activation and Cox-2 synthesis in the brain microvasculature . Positive_regulation NFKB1 IL1B 15900319 1451781 These findings strongly support the hypothesis that *induced* [NFkappaB] activation at the blood-brain interface is a crucial step in the transmission of immune signals from the periphery to the brain that underlies further events responsible of sickness behavior . Positive_regulation NFKB1 IL1B 15901641 1445634 Curcumin ( 10 ( -8 ) M ) , which is known for inhibiting NFkappaB activation , inhibited *induced* MIF secretion as well as [NFkappaB] nuclear translocation and DNA binding . Positive_regulation NFKB1 IL1B 15908470 1451832 In addition , EtOH significantly reduced [NF-kappaB] and AP-1 binding activity *induced* by and inhibited MCP-1 gene transcription . Positive_regulation NFKB1 IL1B 15930438 1414561 Although the mode of action remains to be clarified , our findings support the view that the mechanism of action is via inhibition of *induced* [NF-kappaB] activation . Positive_regulation NFKB1 IL1B 15950952 1427656 The selective impact of HDAC inhibitors on TNF-alpha induced NF-(kappa)B activation appears to relate to the fact that the TNF-alpha induced activation of NF-(kappa)B is mediated by the proteasome , whereas [NF-kappaB] *activation* by is largely proteasome independent . Positive_regulation NFKB1 IL1B 15980221 1424668 The *activation* of [NF-kappaB] by was markedly inhibited by both triptolide and dexamethasone , whereas the activity of AP-1 was not affected by either agent . Positive_regulation NFKB1 IL1B 16029077 1436007 Both [NF-kappaB] and AP-1 deoxyribonucleic acid binding activities were detectable in SW982 cells by EMSA , and they were *induced* by treatment . Positive_regulation NFKB1 IL1B 16046471 1459826 In conclusion , our results indicate that 1 ) IKKbeta phosphorylates multiple p65 sites , 2 ) IKKbeta phosphorylates p65 in an IkappaB-p65 complex , and 3 ) S468 phosphorylation slightly reduces TNF-alpha- and *induced* [NF-kappaB] activation . Positive_regulation NFKB1 IL1B 16077954 1442468 We observed that the induction of [NF-kappaB] binding activity *induced* by either or Abeta ( 25-35 ) showed a peak at 30 min , and significantly declined after 2 h . Positive_regulation NFKB1 IL1B 16077954 1442470 The potentiating effect of Abeta ( 25-35 ) on *induced* [NF-kappaB] binding activity was observed after 30 min , 2 h and 24 h , and did not significantly differ over time . Positive_regulation NFKB1 IL1B 16112536 1507294 *increased* nuclear activated [NF-kappaB] levels in fibroblasts and epithelial cells [ 10- and 2.5-fold over controls , respectively ( p=0.0001 ) ] , and these increases were not significantly affected by MO. PGE ( 2 ) was measured in cell supernatants by ELISA , after preincubation with MO and exposure to IL-1beta . Positive_regulation NFKB1 IL1B 16140882 1450815 PFE also inhibited the *induced* phosphorylation of IkappaBalpha and the DNA binding activity of the transcription factor [NF-kappaB] in OA chondrocytes . Positive_regulation NFKB1 IL1B 16148608 1455212 *induced* [NF-kappaB] activation in vascular smooth muscle cells , and the addition of GGA further inhibited this NF-kappaB activation . Positive_regulation NFKB1 IL1B 16201298 1463891 It was concluded that the expressions of [NF-kappaB] in hRPE cells could be *increased* significantly by and depressed effectively by PDTC . Positive_regulation NFKB1 IL1B 16201298 1463893 Also , PDTC could significantly inhibit the activation of [NF-kappaB] *induced* by . Positive_regulation NFKB1 IL1B 16258173 1489911 Electrophorectic mobility shift assays demonstrate that is a potent *inducer* of [NF-kappaB] translocation ; Positive_regulation NFKB1 IL1B 16286467 1509589 *induction* of [NFkappaB] is partially regulated by H2O2 mediated activation of NFkappaB inducing kinase . Positive_regulation NFKB1 IL1B 16286467 1509601 Although IKKalpha and IKKbeta were both involved in *mediated* activation of [NFkappaB] , only the IKKalpha dependent component was modulated by changes in H2O2 levels . Positive_regulation NFKB1 IL1B 16286467 1509633 In summary , our studies have demonstrated that redox regulation of NIK by H2O2 is mechanistically important in *induction* of [NFkappaB] activation . Positive_regulation NFKB1 IL1B 16317111 1518957 In addition , fluvastatin increased *induced* p65 nuclear translocation and [nuclear factor kappaB (NF-kappaB)] activity , although it inhibited those induced by LPS . Positive_regulation NFKB1 IL1B 16326073 1553801 *induced* [NF-kappaB] activation in Caco-2 cells , promoting the binding of this transcription factor to DNA and increasing NF-kappaB dependent transcription . Positive_regulation NFKB1 IL1B 16338964 1503961 In agreement with the pharmacologic inhibition studies , siRNA directed against c-Src specifically limited c-Src protein expression and inhibited *mediated* induction of [NF-kappaB] DNA binding activity , whereas control siRNA had no effect . Positive_regulation NFKB1 IL1B 16338964 1503965 Conversely , overexpression of constitutively active c-Src augmented basal and *mediated* induction of [NF-kappaB] DNA binding activity and NO production . Positive_regulation NFKB1 IL1B 16339279 1539613 Chromatin immunoprecipitation analysis revealed *induced* binding of [NF-kappaB] to the PR promoter . Positive_regulation NFKB1 IL1B 16354686 1504431 Clearance of both superoxide and H2O2 from within the endosomal compartment significantly abrogated *dependent* IKK and [NF-kappaB] activation . Positive_regulation NFKB1 IL1B 16377638 1526967 Because several of these genes are regulated by NF-kappaB , we postulated that SAHA mediates its effects by modulating NF-kappaB and found that SAHA suppressed [NF-kappaB] activation *induced* by TNF , , okadaic acid , doxorubicin , lipopolysaccharide , H ( 2 ) O ( 2 ) , phorbol myristate acetate , and cigarette smoke ; Positive_regulation NFKB1 IL1B 16385087 1520076 Investigation of potential signaling pathways demonstrated that metformin diminished *induced* activation and nuclear translocation of [nuclear factor-kappa B (NF-kappaB)] in SMCs . Positive_regulation NFKB1 IL1B 16393772 1494466 This can be explained by the fact that the four effective DMARDs also suppressed *induced* activation of [nuclear factor kappa B (NF-kappaB)] , which is a crucial transcription factor for iNOS . Positive_regulation NFKB1 IL1B 16416193 1495004 Colon tissue was collected for assessment of histological changes , [NF-kappa B] *activation* , myeloperoxidase (MPO) activity , and expression of NK-1R , SP , TNFalpha , , VCAM-1 , ICAM-1 , E-selectin , CINC-1 , MIP-1alpha , and iNOS . Positive_regulation NFKB1 IL1B 16417227 1514529 Transcription factor ELISAs indicated that the NF-kappaB heterodimer p50-p65 binds to all three [NF-kappaB] sites in the hBD-2 promoter upon *stimulation* of primary keratinocytes with and PA . Positive_regulation NFKB1 IL1B 16556731 1589297 [NF-kappaB] activation was induced in INS-1E cells and in 208F cells after exposure to cytokines , but apoptosis was *induced* only in INS-1E cells , with a more pronounced proapoptotic effect of than of TNF-alpha . Positive_regulation NFKB1 IL1B 16556731 1589301 Both cytokines induced a prolonged ( up to 48 h ) and stable NF-kappaB activation in INS-1E cells , whereas *induced* an oscillatory [NF-kappaB] activation in 208F cells . Positive_regulation NFKB1 IL1B 16569740 1568494 OTR promoter contains putative transcription factor binding sites for activating protein-1 (AP-1) , CCAAT/enhancer binding protein (C/EBP) , and [nuclear factor-kappaB (NF-kappaB)] , which may be *activated* by , whose concentrations increase with labor . Positive_regulation NFKB1 IL1B 16569740 1568498 IL-1beta induces an increase in OTR mRNA concentrations and OTR ligand binding in myometrial cells , which is maximal at 4 h and decreased after 20 h . *activates* the transcription factors AP-1 C/EBPbeta , and [NF-kappaB] . Positive_regulation NFKB1 IL1B 16581045 1496467 Signal transduction studies revealed that and TNF-alpha stimulation *induced* [NFkappaB] phosphorylation in A549 cells , but antagonist inhibition of NFkappaB p50-p65 phosphorylation correlated with marked reduction of IL-1beta or TNF-alpha induced CCL28 expression . Positive_regulation NFKB1 IL1B 16597919 1589488 We previously showed that the CGRP inhibitory effect was mediated by elevated intracellular cAMP and show here that analogs of cAMP , 8-bromoadenosine 3',5'-cyclic monophosphothioate and the Sp isomer of adenosine 3',5'-cyclic monophosphothioate , mimicked the CGRP suppressive effect on *induced* ROS formation , [NF-kappaB] activation , and MCP-1 secretion . Positive_regulation NFKB1 IL1B 16636195 1562963 A pharmacological activator of AMPK , 5-amino-4-imidazole carboxamide riboside ( AICAR ) , dose-dependently inhibited TNF-alpha- and *induced* [NF-kappaB] reporter gene expression . Positive_regulation NFKB1 IL1B 16636588 1583078 [NF-kappaB] was *activated* within 30 min by tumor necrosis factor-alpha (TNF-alpha) or . Positive_regulation NFKB1 IL1B 16636588 1583081 Intracellular ROS was not produced until 30 min and also antioxidants such as N-acetylcysteine and tiron had no effect on the TNF-alpha- or *induced* [NF-kappaB] activation . Positive_regulation NFKB1 IL1B 16636588 1583084 Silymarin dose-dependently inhibited the TNF-alpha- or induced [NF-kappaB] *activation* and MCP-1 expression . Positive_regulation NFKB1 IL1B 16636588 1583087 *Induction* of [NF-kappaB] within 30 min by TNF-alpha- and was mediated through intracellular calcium but not ROS . Positive_regulation NFKB1 IL1B 16707097 1564049 IL-1Beta activated the extracellular signal regulated kinase 1/2 ( ERK1/2 ) , and this activation was also enhanced by H ( 2 ) S. Inhibition of ERK1/2 activation by the selective inhibitor U0126 inhibited *induced* [NF-kappaB] activation , iNOS expression , and NO production either in the absence or presence of H ( 2 ) S . Positive_regulation NFKB1 IL1B 16707097 1564052 Our findings suggest that H ( 2 ) S enhances NO production and iNOS expression by potentiating *induced* [NF-kappaB] activation through a mechanism involving ERK1/2 signaling cascade in rat VSMCs . Positive_regulation NFKB1 IL1B 16718462 1584925 Furthermore , C3d inhibited NCAM induced FGFR phosphorylation and apoptosis induced by IL-1beta plus IFN-gamma , but did not affect *induced* [NF-kappaB] signalling . Positive_regulation NFKB1 IL1B 16723122 1638327 Finally , we critically review the recent data highlighting the role of ROS in [NF-kappaB] *activation* by proinflammatory cytokines ( TNF-alpha and ) and lipopolysaccharide (LPS) , two major components of innate immunity . Positive_regulation NFKB1 IL1B 16723203 1570381 EMSA data confirm that PDCT , at concentrations sufficient to completely block IL-1beta induced HAS1 transcription , also entirely blocks *induced* [NF-kappaB] translocation . Positive_regulation NFKB1 IL1B 16776851 1663378 Concomitantly , ALP suppressed the induced [NF-kappaB] *activation* and the upregulation of E-selectin expression in glEND.2 cells in vitro . Positive_regulation NFKB1 IL1B 16799025 1579193 Neither IL-4 nor -13 affected the *induced* activation of [NF-kappaB] or the AP-1 component c-Jun . Positive_regulation NFKB1 IL1B 16822942 1638575 Ribosomal S6 kinase-1 modulates induced persistent *activation* of [NF-kappaB] through phosphorylation of IkappaBbeta . Positive_regulation NFKB1 IL1B 16822942 1638585 In conclusion , in the ERK signaling cascade , RSK1 is a key component that directly phosphorylates IkappaBbeta and contributes to the persistent *activation* of [NF-kappaB] by . Positive_regulation NFKB1 IL1B 16840786 1606721 Treatment with SAP inhibited [NF-kappaB] activation *induced* by ; Positive_regulation NFKB1 IL1B 16912429 1602076 Inhibition of *induced* activation of MEK/ERK pathway and DNA binding of [NF-kappaB] and AP-1 : potential mechanism for Diacerein effects in osteoarthritis . Positive_regulation NFKB1 IL1B 16955275 1627635 As to the mechanism of inhibition , electrophoretic mobility shift assay experiments demonstrated that exposure of FLS to hyperthermia prevents *induced* [NF-kappaB] translocation and subsequent DNA binding . Positive_regulation NFKB1 IL1B 17015748 1629897 *activated* [NF-kappaB] but not ERK or p38 . Positive_regulation NFKB1 IL1B 17114179 1677150 Besides TNF , gamma-tocotrienol also abolished [NF-kappaB] activation *induced* by phorbol myristate acetate , okadaic acid , lipopolysaccharide , cigarette smoke , , and epidermal growth factor . Positive_regulation NFKB1 IL1B 17126080 1677628 *induced* nuclear translocation of [NF-kappaB] ( p50 , p65 and c-Rel subunits ) , NF-IL-6 and AP-1 , each with distinct kinetics . Positive_regulation NFKB1 IL1B 17136479 1747060 We have investigated the role of PKB and PDK1 in *induced* [NF-kappaB] activation . Positive_regulation NFKB1 IL1B 17136479 1747069 N-tosyl phenylalanyl chloromethyl ketone ( TPCK ) , wortmannin and Ly294002 inhibited *induced* [NF-kappaB] activation in both systems indicating involvement of the PI3K axis in this response . Positive_regulation NFKB1 IL1B 17227815 1703851 However , inhibition of the RhoA/Rho-kinase pathway did not attenuate the *activation* of [NF-kB] by . Positive_regulation NFKB1 IL1B 17239863 1690547 [Nuclear factor kappaB (NF-kappaB)] activity was *enhanced* by and reduced by aspirin , indicating that decreased ICAM-1 and VCAM-1 expression was due to reduced NF-kappaB activity . Positive_regulation NFKB1 IL1B 17291458 1710968 Treatment of chondrocytes with curcumin suppressed *induced* [NF-kappaB] activation via inhibition of IkappaBalpha phosphorylation , IkappaBalpha degradation , p65 phosphorylation and p65 nuclear translocation . Positive_regulation NFKB1 IL1B 17311279 1719300 Furthermore , *stimulated* translocation of [NF-kappaB] into the nucleus and degradation of IkappaB-alpha was blocked by helenalin . Positive_regulation NFKB1 IL1B 17337443 1726636 IRAK-4 KD cells are severely impaired in [NFkappaB] , JNK , and p38 activation in *response* to or TLR7 ligand . Positive_regulation NFKB1 IL1B 17341614 1665059 [NF-kappaB] was *activated* by TNF-alpha , , PMA , and camptothecin in a dose dependent manner , but not by LPS . Positive_regulation NFKB1 IL1B 17349082 1707997 In the present study , we investigated the effects of EA on the formation of intracellular reactive oxygen species , the translocation of [NFkappaB] and expression of vascular cell adhesion molecule-1 ( VCAM-1 ) , intercellular adhesion molecule-1 and endothelial leucocyte adhesion molecule ( E-selectin ) *induced* by in human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation NFKB1 IL1B 17360530 1712734 Similarly high concentrations of each of these cytokines cross-activate the other pathway : TGFbeta *activates* [NFkappaB] , and activates Smads . Positive_regulation NFKB1 IL1B 17390080 1716150 We have previously demonstrated that *induced* HBD-2 mRNA expression in A549 cells through activation of [nuclear factor-kappaB (NF-kappaB)] transcriptional factor as well as p38 mitogen activated protein kinase (MAPK) , c-Jun N-terminal kinase (JNK) , or phosphatidylinositol-3-kinase (PI3K) . Positive_regulation NFKB1 IL1B 17390080 1716200 Although triptolide partially suppressed *mediated* degradation of IkappaB-alpha and nuclear translocation of p65 [NF-kappaB] , triptolide potently inhibited NF-kappaB promoter-driven luciferase activity in A549 cells . Positive_regulation NFKB1 IL1B 17473513 1738344 Mutations of cyropyrin lead to the persistent production of and *activation* of [NF-kappaB] , followed by excessive inflammtory reactions . Positive_regulation NFKB1 IL1B 17499220 1750899 Inhibitory effect on mediated [NF-kappaB] *activation* was evidenced by the diminishment of IkappaB kinase (IKK) phosphorylation and IkappaBalpha degradation . Positive_regulation NFKB1 IL1B 17548806 1791968 Moreover , ST2825 interfered with recruitment of IRAK1 and IRAK4 by MyD88 , causing inhibition of mediated *activation* of [NF-kappaB] transcriptional activity . Positive_regulation NFKB1 IL1B 17579088 1763916 EMSAs demonstrate that neither BV nor melittin blocked *induced* [NF-kappaB] activation ; Positive_regulation NFKB1 IL1B 17645739 1793278 However , although Dex did not inhibit the nuclear translocation of p65 [NF-kappaB] in *response* to , it profoundly inhibited NF-kappaB promoter- and HBD-2 promoter-driven luciferase activities . Positive_regulation NFKB1 IL1B 17663801 1780454 In *response* to , or IL10 , the levels of phosphorylated [NF-kappaB] and STAT3 -- respectively -- increased significantly for all the studied cell types . Positive_regulation NFKB1 IL1B 17693924 1882308 *causes* nuclear accumulation of [NF-kappaB] ( Rel A ) but does not increase nuclear IkappaBalpha . Positive_regulation NFKB1 IL1B 17888210 1797465 The drug reduced *induced* [NF-kappaB] and AP-1 DNA binding , as well as the phosphorylation of ERK and JNK . Positive_regulation NFKB1 IL1B 17907174 1812702 Cyclic tensile strain rapidly inhibited the *induced* nuclear translocation of [NF-kappaB] , but not its IL-1beta induced phosphorylation at serine 276 and serine 536 , which are necessary for its transactivation and transcriptional efficacy , respectively . Positive_regulation NFKB1 IL1B 17912472 1803864 The molecular mechanism by which RAE inhibited iNOS gene expression appeared to involve the inhibition of [NF-kappaB] activation as a *result* of RAE 's suppression of and IFN-gamma induced IkappaBalpha degradation . Positive_regulation NFKB1 IL1B 17983423 1850442 Chondroitin sulfate reduced *induced* [NF-kappaB] nuclear translocation , but not AP-1 translocation , it decreased IL-1beta induced phosphorylation of Erk1/2 and abrogated p38MAPK phosphorylation , but did not prevent IL-1beta induced increase in nitrite . Positive_regulation NFKB1 IL1B 18029909 1827992 Reporter gene assays showed that FXR ligands activated an FXR reporter gene and suppressed *induced* [nuclear factor (NF)-kappaB] activation and iNOS in a manner that required functional FXR and SHP . Positive_regulation NFKB1 IL1B 18062932 1861578 Avenanthramides , polyphenols from oats , inhibit *induced* [NF-kappaB] activation in endothelial cells . Positive_regulation NFKB1 IL1B 18239685 1871399 Here , we show that Tax1 binding protein 1 (TAX1BP1) is a negative regulator of TNF-alpha- and *induced* [NF-kappaB] activation and that binding to mono- and polyubiquitin by a ubiquitin binding Zn finger domain in TAX1BP1 is needed for TRAF6 association and NF-kappaB inhibition . Positive_regulation NFKB1 IL1B 18260825 1895983 Existence of the canonical IKK2 [ IkappaB ( inhibitor of NF-kappaB ) kinase 2 ] /IkappaBalpha pathway of [NF-kappaB] activation *induced* by in rabbit colonic muscle cells was validated with multiple approaches , including the induction of reporter luciferase activity and endogenous NF-kappaB-target gene expression , NF-kappaB-DNA binding activity , p65 nuclear translocation , IkappaBalpha degradation and the phosphorylation of IKK2 at Ser ( 177/181 ) and p65 at Ser ( 536 ) . Positive_regulation NFKB1 IL1B 18299187 1896725 NUMBL interacts with TAB2 and inhibits TNFalpha and *induced* [NF-kappaB] activation . Positive_regulation NFKB1 IL1B 18300858 1873453 However , the high concentration of D-glucose did increase iNOS expression in response to low concentrations of ( 2.5 and 5 ng/ml ) , as well as the IL-1beta induced *activation* of both ERK 1/2 and [NF-kappaB] . Positive_regulation NFKB1 IL1B 18372240 1888322 Interestingly , the anti-inflammatory cytokines IL-4 , IL-13 and IL-10 decreased *stimulated* [NFkappaB] activation and iNOS expression . Positive_regulation NFKB1 IL1B 18375401 1899024 Diacerein and NSAIDs inhibited *stimulated* [NF-kappaB] activation in synoviocytes and chondrocytes except indomethacin in synoviocytes . Positive_regulation NFKB1 IL1B 18378695 1906986 The compartmentalized production of superoxide ( *O ( 2 ) ( - ) ) by endosomal NADPH oxidase is important in the redox dependent *activation* of [NF-kappaB] following stimulation . Positive_regulation NFKB1 IL1B 18389480 1899272 All the three IL enhanced the basal and *induced* transcriptional activities of [NF-kappaB] , while IL-12 and IL-27 enhanced STAT3 and STAT1 activities , respectively . Positive_regulation NFKB1 IL1B 18467203 1921436 EMSA showed that and TNF-alpha *activated* [NF-kappaB] and AP-1 in MG-63 cells . Positive_regulation NFKB1 IL1B 18467203 1921440 *stimulated* [NF-kappaB] via a non-canonical pathway ( p52/p65 ) and TNF-alpha via the canonical pathway ( p50/p65 ) . Positive_regulation NFKB1 IL1B 18510099 1840590 IRAK-4 KD cells were severely impaired in [NF-kappaB] , JNK , and p38 activation in *response* to or TLR7 ligand . Positive_regulation NFKB1 IL1B 18524861 1939830 *activated* [NF-kappaB] and increased ET-1 release in a concentration dependent manner . Positive_regulation NFKB1 IL1B 18556347 1965891 *enhanced* the transcriptional activity of [NF-kappaB] , whereas leptin enhanced STAT1 and STAT3 activity . Positive_regulation NFKB1 IL1B 18556347 1965906 The p38 MAPK inhibitor SB202190 suppressed IL-1beta- and IL-1beta plus leptin induced hBD-2 production , *induced* [NF-kappaB] activity , and leptin induced STAT1 and STAT3 activity ; Positive_regulation NFKB1 IL1B 18556347 1965947 IL-1beta or leptin individually induced threonine/tyrosine phosphorylation of p38 MAPK , whereas only leptin induced tyrosine phosphorylation of JAK2 , suggesting that leptin may enhance hBD-2 production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with [NF-kappaB] , which is *activated* by . Positive_regulation NFKB1 IL1B 18599158 2208607 and ( 3 ) S100B/RAGE induced upregulation of COX-2 , and TNF-alpha expression *requires* the concurrent activation of [NF-kappaB] and AP-1 . Positive_regulation NFKB1 IL1B 18658272 1967184 Neither flagellin nor altered transepithelial fluxes of membrane-impermeant dextran ( 10 kDa ) or lucifer yellow ( mol wt = 457 ) , but both *activated* p38 , [NF-kappaB] , and IL-8 secretion . Positive_regulation NFKB1 IL1B 18676628 1979508 In contrast to dexamethasone , TPCA-1 inhibited the phosphorylation and degradation of IkappaBalpha and the nuclear translocation of [NF-kappaB] *induced* by . Positive_regulation NFKB1 IL1B 18708082 1974584 Consistently , *stimulated* both IkappaB-alpha degradation and [NF-kappaB] translocation into nucleus in these cells . Positive_regulation NFKB1 IL1B 18772363 1985854 Because also *activates* [NF-kappaB] signaling , we investigated disparate HKalpha regulation by H. pylori and IL-1beta , testing the hypothesis that IL-1beta induced HKalpha promoter activation is mediated by the transcription factor Sp1 . Positive_regulation NFKB1 IL1B 18779659 1963177 The stimulation of lymphoid cells with TNF-alpha , , and LPS *resulted* in significant ROS production and [NF-kappaB] activation . Positive_regulation NFKB1 IL1B 18801189 1969506 These observations concurred with lack of a modulatory activity of IFNgamma on induced [NF-kappaB] *activation* as assessed by cellular IkappaB levels . Positive_regulation NFKB1 IL1B 18936492 1982147 In Caco-2 cells transfected with a reporter gene for NF-kappaB activity , F. prausnitzii had no effect on *induced* [NF-kappaB] activity , whereas the supernatant abolished it . Positive_regulation NFKB1 IL1B 19007749 2016468 Infection of FLS with Ad-IkappaB alpha ( S32A , S36A ) , an adenovirus containing mutant IkappaB alpha , inhibited *induced* nuclear translocation and DNA binding of [NF-kappaB] . Positive_regulation NFKB1 IL1B 19056796 2017702 Moreover , cordycepin significantly inhibited induced p38/JNK and AP-1 activation , but not extracellular signal regulated kinase ( ERK ) and [NF-kappaB] *activation* . Positive_regulation NFKB1 IL1B 19067146 2024085 The TNBS treatment caused colon shortening , increased myeloperoxidase activity , *induced* , TNF-alpha , and IL-6 expression in the colon , activated [NF-kappaB] , and potentiated the GAG degrading activities of intestinal microflora . Positive_regulation NFKB1 IL1B 19086277 2000196 Furthermore , LGG attenuated the *induced* transcriptional activation of the IL-8 gene and the [NF-kappaB-responsive] gene , and attenuated the IL-1beta induced IkappaBalpha degradation . Positive_regulation NFKB1 IL1B 19170127 2049006 Concomitant administration of Dex , a known NF-kappaB inhibitor , resulted in significantly down-regulated *induced* [NF-kappaB/p65] activity , as well as reduced expression of chemokine receptors and IL-17F in mouse prostate tissue . Positive_regulation NFKB1 IL1B 19229069 2054622 Neutralization of the IL-8 receptor , CXCR2 , further induced VCAM-1 in the *presence* of , and phospho-p38 was required for [NF-kappaB] activation and VCAM-1 expression . Positive_regulation NFKB1 IL1B 19229069 2054633 Additionally , IL-8 reduced p38 activation and [NF-kappaB] activity *induced* by alone . Positive_regulation NFKB1 IL1B 19232515 2050519 Overexpression of FBXW5 inhibited induced *activation* of JNK/p38 MAPKs and [NF-kappaB] as well as phosphorylation of TAK1 on Thr187 . Positive_regulation NFKB1 IL1B 19249288 2050970 Hydrogen-rich saline treatment decreased the neutrophil infiltration , the lipid membrane peroxidation , [NF-kappaB] *activation* and the pro-inflammatory cytokine interleukin and TNF-alpha in the lung tissues compared with those in saline treated rat . Positive_regulation NFKB1 IL1B 19281832 2072886 Moreover , *stimulated* [NF-kappaB] and CaMKII phosphorylation through MyD88 dependent PI-PLC/PKCalpha/c-Src/ROS and PI-PLC/Ca2+/CaM pathways , respectively . Positive_regulation NFKB1 IL1B 19342688 2056878 In addition , induced phosphorylation of downstream effectors , IkappaB kinase alphabeta , IkappaBalpha , and *activation* of transcription factor [NF-kappaB] was significantly reduced in the MyD88- , IRAK1- , TRAF6- , or Ras-deficient cells . Positive_regulation NFKB1 IL1B 19347386 2128095 The Deltapsim of hepatocytes was markedly decreased after IL-1beta stimulation which was significantly attenuated by Gln at 5 and 10 mmol/l . [NF-kappaB] activity was *increased* by stimulation and this effect was augmented by Gln at 5 and 10 mol/l . Positive_regulation NFKB1 IL1B 19410980 2075262 Moreover , it suppressed *induced* [NF-kappaB] activation , including NF-kappaB dependent reporter gene expression in a dose dependent manner . Positive_regulation NFKB1 IL1B 19423159 2089901 Cx43 liposomes containing a soluble NEMO binding domain peptide suppressed the intracellular signaling cascade induced [NF-kappaB] *activation* and cyclooxygenase-2 expression in Cx43 expressing cells , confirming effective peptide transfer into the cell . Positive_regulation NFKB1 IL1B 19446813 2141903 Furthermore , digitoxin prevented the *induced* activation of p44/42-MAPK and [NF-kappaB] without affecting activation of JNK and p38-MAPK . Positive_regulation NFKB1 IL1B 19451246 2096980 PAK DeltafliC also inhibited [NF-kappaB] *induced* by and Toll-like receptor 2 agonist Pam3CSK4 . Positive_regulation NFKB1 IL1B 19521662 2108914 Transforming growth factor-beta activated kinase 1 ( TAK1 ) is a serine/threonine protein kinase that is critically involved in the *activation* of [NF-kappaB] by tumor necrosis factor ( TNFalpha ) , and TLR ligands . Positive_regulation NFKB1 IL1B 19607676 2112178 Inhibition of [nuclear factor kappa B (NF-kappaB)] activation *induced* by and IFN-gamma was investigated . Positive_regulation NFKB1 IL1B 19625606 2131258 We conclude that IL-1alpha and act via an oxidant- and AKT/Foxo independent mechanism to activate p38 MAPK , *stimulate* [NF-kappaB] signaling , increase expression of atrogin1/MAFbx and MuRF1 , and reduce myofibrillar protein in differentiated myotubes . Positive_regulation NFKB1 IL1B 19672968 2182996 *stimulated* IkappaBalpha degradation , [NF-kappaB] nuclear translocation , and transactivation in astrocytes . Positive_regulation NFKB1 IL1B 19765584 2153537 Likewise , NAC only inhibited *stimulated* [NF-kappaB] activation in synoviocytes . Positive_regulation NFKB1 IL1B 19836480 2203152 Curcumin blocks *induced* proteoglycan degradation , [AP-1/NF-kappaB] signalling , chondrocyte apoptosis and activation of caspase-3 . Positive_regulation NFKB1 IL1B 19887769 2197288 Both TNF-alpha and *activated* [NF-kappaB] and stimulated IL-8 production . Positive_regulation NFKB1 IL1B 19921217 2203714 The influence of NFkappaB inhibitors ( dexamethasone , pyrrolidine dithiocarbamate ( PDTC ) and BAY 11-7082 ) on *induced* [NFkappaB] transcriptional activity was investigated by transient transfection of Caco-2 cells with an NFkappaB secreted alkaline phosphatase reporter plasmid . Positive_regulation NFKB1 IL1B 19929594 2171915 IFN-gamma does not affect the transient *activation* of classical [NF-kappaB] by and synergistic induction of ip-10 expression by IFN-gamma and IL-1beta occurs even after the activation of classical NF-kappaB has returned to basal levels . Positive_regulation NFKB1 IL1B 19962969 2204169 Both LT and DN-p38 decreased *induced* [NF-kappaB] luciferase activity . Positive_regulation NFKB1 IL1B 20038579 2205272 Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and *induced* [IKK/NF-kappaB] and JNK/AP-1 activation . Positive_regulation NFKB1 IL1B 20039418 2192709 Fasudil inhibited *induced* activation of [NF-kappaB] independent of the inhibition of IkappaBalpha degradation and nuclear translocation of NF-kappaB , and inhibited IL-1beta induced DNA binding of NF-kappaB . Positive_regulation NFKB1 IL1B 20067961 2241607 Although both glucose and cream induce [NF-kappaB] binding and an increase in the expression of SOCS3 , TNF-alpha , and in MNCs , only cream *caused* an increase in LPS concentration and TLR-4 expression . Positive_regulation NFKB1 IL1B 20116443 2258840 C4S inhibited the enhanced expression of COX-2 and mPGES1 but had no effect on the *induced* decrease of I-kappaBalpha and nuclear translocation of [NF-kappaB] . Positive_regulation NFKB1 IL1B 20145375 2280997 ( 4 ng/ml , 10 min ) *induced* phosphorylation of [NF-kappaB] , JNK , and ERK . Positive_regulation NFKB1 IL1B 20145375 2281000 Angiotensin II augmented the *induced* phosphorylation of ERK but not [NF-kappaB] and JNK . Positive_regulation NFKB1 IL1B 20181058 2222751 potently *induced* [NF-kappaB] activation in CaCo-2 cells , but did not induce TLR-4 expression . Positive_regulation NFKB1 IL1B 20222108 2265578 *Enhancement* of [NF-kappaB] activation by adiponectin as well as by was observed in RASFs . Positive_regulation NFKB1 IL1B 20432452 2268150 Moreover , *stimulated* [NF-kappaB] p65 translocation was blocked by helenalin , but not by U0126 or SP600125 , revealing that MAPKs and NF-kappaB pathways were independent on these responses . Positive_regulation NFKB1 IL1B 20484576 2288695 PLK1 inhibits [NF-kappaB] transcriptional activation *induced* by TNF-alpha , , or several activators , but not by nuclear transcription factor p65 . Positive_regulation NFKB1 IL1B 20525168 2284217 We have shown that *induced* miR-146a expression in HASM and that this was regulated at the transcriptional level by [NF-kappaB] and at the post-transcriptional level by the MEK-1/2 and JNK-1/2 . Positive_regulation NFKB1 IL1B 20543863 2308295 Our results suggest that membranous L1CAM interacts with RGD binding integrins , leading to sustained [NF-kappaB] *activation* by production and autocrine/paracrine signalling . Positive_regulation NFKB1 IL1B 20600535 2316084 Moreover , *induced* activator protein-1 (AP-1) and [nuclear factor-kappaB (NF-kappaB)] activation were inhibited by luteolin . Positive_regulation NFKB1 IL1B 20717945 2312997 *increased* [nuclear factor (NF)-kappaB] activation and nuclear translocation . Positive_regulation NFKB1 IL1B 23136298 2729442 As expected , *induced* [NFKB] transcriptional activity . Positive_regulation NFKB1 IL1B 23452206 2787386 Cigarette smoke condensate extracts *induce* production from rheumatoid arthritis patient derived synoviocytes , but not osteoarthritis patient derived synoviocytes , through aryl hydrocarbon receptor dependent [NF-kappa-B] activation and novel NF-kappa-B sites . Positive_regulation NFKB1 IL1B 24009751 2836891 Earlier we reported that *activated* [NFkB] down-regulates gastrin , the major hormonal regulator of acid secretion . Positive_regulation NFKB1 IL1B 24009751 2836895 In this study , the probable pathway by which *induces* [NFkB] and affects gastrin expression has been elucidated . Positive_regulation NFKB1 IL1B 7540991 310184 N , N,N-trimethylsphingosine inhibits induced [NF-kappa B] *activation* and consequent E-selectin expression in human umbilical vein endothelial cells . Positive_regulation NFKB1 IL1B 7540991 310188 Electrophoretic mobility shift assay revealed that TMS inhibited *induced* [NF-kappa B] activation , which is essential for E-selectin expression . Positive_regulation NFKB1 IL1B 7545088 318478 Here we demonstrate that *induces* nuclear translocation of [NF kappa B] in human umbilical vein endothelial cells , followed by induction of cell surface expression of E-selectin , intercellular adhesion molecule-1 , and vascular adhesion molecule 1 , and subsequently augments adhesion of those cancer cells expressing sialyl Lewis X antigen , a ligand to E-selectin . Positive_regulation NFKB1 IL1B 7556162 327629 [NF-kappa B] is also *activated* by in HUVE cells , but this activation occurs without increased PKR autophosphorylation or eIF2 alpha phosphorylation . Positive_regulation NFKB1 IL1B 7589098 334008 IL-4 was also found partially to inhibit [NF kappa B] activity *induced* by tumor necrosis factor-alpha (TNF-alpha) and . Positive_regulation NFKB1 IL1B 7864166 296331 increases laminin B2 chain mRNA levels and *activates* [NF-kappa B] in rat glomerular epithelial cells . Positive_regulation NFKB1 IL1B 8074648 270512 Using the insulin producing rat cell line RINm5F and an electrophoretic mobility shift assay ( EMSA ) , it was presently found that *induced* a rapid activation ( 5 min ) of the transcription factor [NF-kappa B] and that this event was prevented by the protease inhibitor N alpha-p-tosyl-L-lysine chloromethylketone ( TLCK ) . Positive_regulation NFKB1 IL1B 8074713 270570 In human astrocytoma and neuroblastoma cell lines tumour necrosis factor alpha (TNF alpha) and *induced* [NFKB] and an additional KB-specific protein of approximately 80 K to bind the HIV-1 enhancer . Positive_regulation NFKB1 IL1B 8579596 350552 Tyrosine kinase inhibitors , genistein and herbimycin A , do not block *induced* activation of [NF-kappa B] in rat mesangial cells . Positive_regulation NFKB1 IL1B 8579596 350556 Since both COX-2 and iNOS promoters have a kappa B binding motif , we have evaluated the effects of tyrosine kinase inhibitors on *induced* [nuclear factor-kappa B (NF-kappa B)] activation by electromobility shift assays . Positive_regulation NFKB1 IL1B 8579596 350560 rapidly *induced* the translocation of [NF-kappa B] in rat mesangial cells . Positive_regulation NFKB1 IL1B 8579596 350562 These data suggest that an upstream tyrosine kinase pathway may not be required for *induced* [NF-kappa B] activation and that the tyrosine kinase pathway may converge with the NF-kappa B pathway down-stream of NF-kappa B activation in rat mesangial cells . Positive_regulation NFKB1 IL1B 8621602 354194 C2-ceramide and sphingomyelinase induced [NF-kappaB] activation by themselves and enhanced *activation* by , which is essential for E-selectin expression . Positive_regulation NFKB1 IL1B 8626526 360413 Binding to the [NF-kappaB] element was strongly *induced* by , but not by acetylsphingosine or PMA . Positive_regulation NFKB1 IL1B 8809309 383096 The aim now was to investigate whether recombinant ( r ) *induces* the stimulation of [NF kappa B] and its inhibitor proteins in human gingival fibroblasts and to understand if inhibition of its activity affects collagenase gene expression . Positive_regulation NFKB1 IL1B 8830655 385503 We found that binding of [NFkappaB] is strongly *induced* in mesangial cells by both and TNF-alpha . Positive_regulation NFKB1 IL1B 8863511 388843 Here , we describe that both and TNF alpha *activate* the transcription factor [nuclear factor-kappa B (NF-kappa B)] via production of reactive oxygen intermediates resulting in ACT expression . Positive_regulation NFKB1 IL1B 8943367 399991 In addition , expression of a dominant negative rac1 mutant ( N17rac1 ) inhibits basal and *stimulated* [NF-kappaB] activity . Positive_regulation NFKB1 IL1B 8977194 408709 *stimulated* [NF-kappaB] nuclear translocation and NF-kappaB dependent IL-1beta and IL-8 expression in both Caco-2 and HT-29 cells as assayed by electrophoretic mobility shift assay , immunofluorescence , kappaB-luciferase transfection , reverse transcriptase-PCR analysis and ELISA . Positive_regulation NFKB1 IL1B 8977194 408711 These data show that *induces* [NF-kappaB] activity and expression of NF-kappaB dependent genes in colonic epithelial cells and suggest altered regulation of IkappaB alpha degradation compared with other cell lineages , which may result in their increased responsiveness to therapeutic blockade . Positive_regulation NFKB1 IL1B 8986132 404010 Moreover , ebselen did not prevent *induced* [NF-kappa B] activation . Positive_regulation NFKB1 IL1B 9022680 405595 In this report , we first demonstrated that is a potent *activator* of [NF-kappa B] in various epithelial transformed cell lines ( OVCAR-3 , SKOV-3 , MCF7 A/Z ) . Positive_regulation NFKB1 IL1B 9022680 405598 We showed that *mediated* induction of [NF-kappa B] in OVCAR-3 and in other epithelial cell lines does not proceed through the production of reactive oxygen intermediates , while the same cytokine activates NF-kappa B in lymphoid cells through the intracellular generation of H2O2 . Positive_regulation NFKB1 IL1B 9041934 416035 rapidly *stimulated* the translocation of the p65 , p50 , and c-rel [NF-kappa B] subunits from the cytoplasm to the nucleus . Positive_regulation NFKB1 IL1B 9299557 453826 However , A20 mutants that no longer associated with 14-3-3 proteins could still fully inhibit [NF-kappaB] activation *induced* by tumor necrosis factor , or phorbol 12-myristate 13-acetate , thus excluding a crucial role for 14-3-3 interaction in this A20 function . Positive_regulation NFKB1 IL1B 9323084 456529 Radioligand binding and electrophoretic mobility shift assays showed that during chronic hypoxia , IL-1 receptor density and activity of the transcription factor [NF-kappaB] *induced* by were decreased , which may account at least in part for the decrease in iNOS expression . Positive_regulation NFKB1 IL1B 9331934 457588 In the present study using primary human fetal astrocyte cultures , we found that *stimulated* activation of [nuclear factor kappa B (NF-kappa B)] within 2 h , iNOS mRNA expression at 8 h , and maximal NO production by 5 days post-treatment . Positive_regulation NFKB1 IL1B 9332715 457651 The oxidative stress responsive transcription factor [nuclear factor-kappa B (NF-kappa B)] consists of a p50 ( 50 kDa ) and p65/RelA ( 65 kDa ) component and can be *activated* in vitro by TNF alpha , , hydrogen peroxide and oxygen radicals . Positive_regulation NFKB1 IL1B 9337212 458224 In contrast , superoxide dismutase did not inhibit the induced [NF-kappaB] *activation* . Positive_regulation NFKB1 IL1B 9436821 474860 Thiopental did not affect the *stimulated* activation of [NF-kappaB] in VSMCs . Positive_regulation NFKB1 IL1B 9506955 491505 However , *induced* IkappaBalpha degradation as well as [NF-kappaB] nuclear translocation and DNA binding , as determined by Western blot and electro-mobility shift assay , respectively , are not affected by these inhibitors . Positive_regulation NFKB1 IL1B 9523575 493933 Promoter deletion analysis revealed that induced IL-6 expression *required* the transcription factor [nuclear factor-kappaB (NF-kappaB)] , whereas SP- and histamine induced IL-6 synthesis was essentially controlled by NF-IL-6 . Positive_regulation NFKB1 IL1B 9568691 501337 TLCK and MG 132 inhibited both *induced* activation of [NFkappaB] and degradation of IkappaBalpha by islets and RINm5F cells . Positive_regulation NFKB1 IL1B 9588901 504694 [NF-kappaB] activation during IgG immune complex induced lung injury : *requirements* for TNF-alpha and but not complement . Positive_regulation NFKB1 IL1B 9652398 515850 Effect of dexamethasone on *induced* [nuclear factor-kappaB (NF-kappaB)] and kappaB dependent transcription in epithelial cells . Positive_regulation NFKB1 IL1B 9652398 515852 Similarly , BEAS-2B cells showed no effect of dexamethasone on *induced* [NF-kappaB] ( p50/p65 ) . Positive_regulation NFKB1 IL1B 9662438 518260 Human/mouse interleukin-1 receptor/receptor accessory protein interactions in induced [NFkappaB] *activation* . Positive_regulation NFKB1 IL1B 9662438 518265 In non transfected C127 cells , signalled through the mIL-1RI-mIL-1RAcP complex and *activated* [NFkappaB] p50/p65 heterodimers . Positive_regulation NFKB1 IL1B 9662438 518271 In C127-hIL-1RI cells , signalled through the hIL-1RI and *activated* both p65/p65 and p50/p65 [NFkappaB] complexes , where only the activation of NFkappaB p65/p65 was dependent on mIL-1RAcP . Positive_regulation NFKB1 IL1B 9681388 521140 With the aim of investigating the importance of the IL-1RAcP in IL-1 signalling , IL-1alpha and IL-1beta induced febrile responses and *mediated* activation of [NFkappaB] in primary astrocyte cultures were examined using IL-1RAcP-deficient ( IL-1RAcP KO ) and wild type mice , respectively . Positive_regulation NFKB1 IL1B 9681388 521142 Furthermore , it was shown that rhIL-1beta activated , in a concentration dependent manner , nuclear translocation of the transcriptional nuclear factor kappa B (NFkappaB) in primary astrocyte cultures prepared from wild type mice , whereas no *induced* translocation of [NFkappaB] could be detected in cultures prepared from IL-1RAcP-deficient mice , as revealed by electrophoretic mobility shift assay ( EMSA ) . Positive_regulation NFKB1 IL1B 9727370 529922 Electrophoretic mobility shift assays ( EMSA ) showed that and tumor necrosis factor-alpha *activated* [NF-kappaB] from 15 min to 48 h after stimulation . Positive_regulation NFKB1 IL1B 9754830 535234 In these cells IFN-gamma potentiation is mostly mediated by GAS and ISRE , suggesting a role for the IFN-gamma induced transcription factors Stat1alpha ( which binds GAS ) and IRF-1 ( which binds ISRE ) , which may cooperate with [NF-kappaB] *induced* by for iNOS activation . Positive_regulation NFKB1 IL1B 9759860 536570 *Activation* of [NF-kappaB] by was markedly less sensitive to both cPLA2 and sPLA2 inhibitors . Positive_regulation NFKB1 IL1B 9794459 543058 Neutral SMase , , and TNF alpha *activated* [NF-kappaB] , as revealed by electrophoretic mobility shift assay , and its nuclear translocation , as demonstrated by immunocytochemical study . Positive_regulation NFKB1 IL1B 9812920 545988 Electrophoretic mobility shift assay using synthetic oligonucleotide corresponding to the downstream NF-kappaB site of rat iNOS promoter as a probe showed that NOR3 inhibited *induced* [NF-kappaB] activation and its nuclear translocation , as demonstrated with immunocytochemical study . Positive_regulation NFKB1 IL1B 9950608 589834 TNF-alpha , , and TII but not IFN-gamma alone caused degradation of I kappaB , Rel A nuclear translocation , and *increased* [NF-kappaB] DNA binding activity , effects that were blocked by pretreatment with MG-132 . Positive_regulation NFKB1 IL1R2 10383449 624594 Because it has been shown that members of the TRAF family are involved in *activation* of [NF-kappaB] and the c-Jun N-terminal kinase (JNK) by the and members of the TNF receptor superfamily , a role of TRAF1 in receptor cross-talk and/or feedback regulation of activated receptor signaling complexes can be suggested . Positive_regulation NFKB1 IL1R2 19679662 2144286 Moreover , overexpression of a green fluorescent protein ( GFP ) -tagged mini-MyD88 protein ( GFP-MyD88- ( 27-72 ) ) , comprising the Glu ( 52 ) and Tyr ( 58 ) residues , interfered with recruitment of both IRAK1 and IRAK4 by MyD88 and suppressed [NF-kappaB] *activation* by the but not by the MyD88 independent TLR3 . Positive_regulation NFKB1 IL1RL1 7629057 316541 Moreover , expression of the membrane bound protein in transiently transfected Jurkat cells did not *result* in activation of the transcription factor [NF-kappa B] following IL-1 beta treatment . Positive_regulation NFKB1 ITGB2 11701612 878735 *dependent* activation of [NF-kappaB] was potentiated by wild-type , and attenuated by dominant negative , TRAF6- and TGF-beta activated kinase ( TAK1 ) constructs . Positive_regulation NFKB1 ITGB2 12600815 1099096 IL-3 , IL-5 , and GM-CSF could enhance p38 MAPK and [NF-kappaB] activity and *induce* ICAM-1 , CD11b , and expressions on eosinophils . Positive_regulation NFKB1 ITGB2 14613935 1187977 Co-stimulating and CD11b with activating antibodies *resulted* in [NF-kappaB] activation by GM-CSF and IL-8 in suspended cells . Positive_regulation NFKB1 ITGB2 15886116 1406849 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , *activation* of the [NF-kappaB] transcription factor , inside-out activation of the integrin , TCR clustering , and polarisation of the T cell . Positive_regulation NFKB1 ITGB2 9062344 417863 dependent oxidative [NF-kappaB] *activation* leading to nitric oxide production in rat Kupffer cells cocultured with syngeneic hepatoma cells . Positive_regulation NFKB1 JAG1 12107827 963113 mediated activation of notch signaling *induces* complete maturation of human keratinocytes through [NF-kappaB] and PPARgamma . Positive_regulation NFKB1 LBP 16123407 1449373 Combined stimulation with LPS and either sCD14 or also *induced* the phosphorylation and degradation of IkappaB-alpha and the translocation of [NF-kappaB] from the cytoplasm to the nucleus of corneal fibroblasts . Positive_regulation NFKB1 LBP 20615568 2309981 Despite activating NFkappaB , NOD1 ligand did not upregulate hepatocyte production of the acute phase proteins lipopolysaccharide binding protein , serum amyloid A , or soluble CD14 in cell culture supernatants , or upregulate mRNA expression of , serum amyloid A , C-reactive protein , or serum amyloid P . NOD2 ligand ( MDP ) did not *activate* hepatocytes when given alone , but did synergize with Toll-like receptor ligands , lipopolysaccharide (LPS) , and polyI : C to activate [NFkappaB] and MAPK . Positive_regulation NFKB1 MAP2K6 10878013 722389 A constitutive active -- > ERK pathway negatively *regulates* [NF-kappa B-dependent] gene expression by modulating TATA binding protein phosphorylation . Positive_regulation NFKB1 MAP2K6 11157486 780784 These studies suggest that the induced expression of TF by OSM is primarily through the *activation* of [NF-kappaB] and that activation of NF-kappaB is regulated in part by the signal transduction pathway . Positive_regulation NFKB1 MAP2K6 11741913 904977 Analyzing the effects of several inhibitors or mutant receptors revealed that this [NF-kappa B] activation is *mediated* neither by nor by the phosphatidylinositol 3-kinase pathway but by STAT5 . Positive_regulation NFKB1 MAP2K6 11885780 894108 The activations of CREB and [NF-kappaB] were *blocked* by inhibitors of either p38 ( SB-203580 ) or ( PD-098059 ) , suggesting that they were events downstream of MAK kinase . Positive_regulation NFKB1 MAP2K6 15652235 1364143 PD98059 , a inhibitor , and BAY 11-8702 , an I kappa B-alpha inhibitor , *reduced* ERK and [NF-kappa B] cascade activation , respectively , with little effect on PKC phosphorylation . Positive_regulation NFKB1 MAP2K6 16467309 1548207 Activation of PAR-1 or PAR-2 promoted nuclear translocation and phosphorylation of p65-NF-kappaB , and thrombin induced but not PAR-2 induced [p65-NF-kappaB] phosphorylation was *reduced* by inhibition of or p38MAPK . Positive_regulation NFKB1 MAP2K6 17274000 1697309 Inhibitors of PI3 K , p38 MAPK , and *suppressed* IL-18 plus IFN-gamma induced CXCL9 , CXCL10 , and CXCL11 production and [NF-kappaB] , STAT1 , and IRF-1 activities . Positive_regulation NFKB1 MAP2K6 18834856 1981687 The specific inhibitor , U0126 , significantly *blocks* TRAIL mediated [NF-kappaB] activation and subsequent MMP-9 induction . Positive_regulation NFKB1 MAP2K6 9525929 495486 *activates* myocardial cell [NF-kappaB] and inhibits apoptosis in a p38 mitogen activated protein kinase dependent manner . Positive_regulation NFKB1 MMP28 17907155 1812624 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not *prevent* HGF induced ERK-1/2 phosphorylation and [NF-kappaB] activity , but significantly restored HGF inhibited collagen and CTGF accumulation . Positive_regulation NFKB1 MMP7 17907155 1812640 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not *prevent* HGF induced ERK-1/2 phosphorylation and [NF-kappaB] activity , but significantly restored HGF inhibited collagen and CTGF accumulation . Positive_regulation NFKB1 NEDD9 13679070 1140265 Our findings suggest that is *involved* in Casper mediated regulation of apoptosis and [NF-kappaB] activation . Positive_regulation NFKB1 NES 9427296 472700 Furthermore , in cells pulsed with TNF , a treatment which favors nuclear accumulation of newly synthesized IkappaBalpha , expression *promoted* sustained accumulation of nuclear [NF-kappaB] lacking DNA binding activity . Positive_regulation NFKB1 NES 9427296 472702 This *mediated* accumulation of inactive nuclear [NF-kappaB] is likely the consequence of interference in the IkappaBalpha mediated export of NF-kappaB . Positive_regulation NFKB1 PECAM1 19390054 2094938 Inward remodeling was associated with dependent [NFkappaB] *activation* , surface adhesion molecule expression , and leukocyte infiltration as well as Akt activation and vascular cell proliferation . Positive_regulation NFKB1 PECAM1 20173029 2215491 *had* no effect on the phosphorylation of the [NF-kappaB] inhibitory protein , IkappaBalpha ; Positive_regulation NFKB1 PIGR 20450283 2257156 Induction of expression in HT-29 cells *required* [NF-kappaB] signaling but not MAPK signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation NFKB1 PLAT 17717150 1801503 In conclusion , our results demonstrate that after MCAO the interaction between and LRP *results* in [NF-kappaB] activation in astrocytes and induction of inducible nitric-oxide synthase expression in the ischemic tissue , suggesting a cytokine-like plasminogen independent role for tPA during cerebral ischemia . Positive_regulation NFKB1 PLAU 11689575 903857 The urokinase-type plasminogen activator ( uPA ) promoter contains an NF-kappaB binding site , and expression in MDA-MB-231 cells is *induced* by the constitutively active [NF-kappaB] . Positive_regulation NFKB1 PLAU 12759445 1091211 In particular , *increased* LPS induced activation of intracellular signaling pathways , including Akt and c-Jun N-terminal kinase , nuclear translocation of the transcriptional regulatory factor [NF-kappa B] , and expression of proinflammatory cytokines , including IL-1 beta , macrophage-inflammatory protein-2 , and TNF-alpha . Positive_regulation NFKB1 PLAU 17200110 1702345 In this report , we show that KGF/FGF-7 activated [nuclear factor kappaB (NF-kappaB)] , which in turn *induced* expression of VEGF , MMP-9 , and and increased migration and invasion of KGF/FGF-7 stimulated human pancreatic ductal epithelial cells . Positive_regulation NFKB1 PLAU 1905804 161656 Our results suggest that maximal transcriptional activation of the gene by PMA , IL-1 and TNF alpha *requires* the induction of [NFkB] activity and the decay of a short lived repressor protein , possibly IkB . Positive_regulation NFKB1 PTGER2 20516073 2295211 Shear induced interleukin-6 synthesis in chondrocytes : *roles* of and EP3 in cAMP/protein kinase A- and PI3-K/Akt dependent [NF-kappaB] activation . Positive_regulation NFKB1 RCAN1 17062574 1654646 To elucidate the molecular basis of these anti-inflammatory effects , we analyzed the *role* of in the regulation of [NF-kappaB] transactivation using glioblastoma cells stably transfected with DSCR1 .4 or its truncation mutants ( DSCR1.4- ( 1-133 ) and DSCR1 .4- ( 134-197 ) ) . Positive_regulation NFKB1 RCAN1 19716405 2158172 also *stimulated* IL-1R mediated signaling pathways , TAK1 activation , [NF-kappaB] transactivation , and IL-8 production , all downstream consequences of IL-1R activation . Positive_regulation NFKB1 S100B 15590067 1346033 On the other hand , *stimulated* [NF-kappaB] transcriptional activity in BV-2 microglia in a manner that was strictly dependent on RAGE transducing activity , pointing to additional , RAGE mediated effects of the protein on microglia that remain to be investigated . Positive_regulation NFKB1 S100B 18599158 2208605 and ( 3 ) induced upregulation of COX-2 , IL-1beta and TNF-alpha expression *requires* the concurrent activation of [NF-kappaB] and AP-1 . Positive_regulation NFKB1 S100B 20069545 2201283 Conversely , silencing expression in myoblast cell lines by RNA interference *resulted* in reduced [NF-kappaB] activity and enhanced MyoD , myogenin and MyHC expression and myotube formation . Positive_regulation NFKB1 SPHK1 16038795 1437474 Suppression of activation led to reduction of cytokine induced IkappaBalpha phosphorylation and consequently *diminished* [NFkappaB] activity due to reduced nuclear translocation of RelA ( p65 ) , explaining the dependence of inflammatory mediator production on SPHK1 activation . Positive_regulation NFKB1 SPON2 20205276 2223013 expression is upregulated during intestinal inflammation and may *induce* [NF-kappaB] promoter activation in a TLR-9 mediated manner . Positive_regulation NFKB1 STK39 10485710 644369 [NF-kappaB] activation by tumour necrosis factor *requires* the Akt . Positive_regulation NFKB1 STK39 10485710 644429 Here we show that the Akt is *involved* in the activation of [NF-kappaB] by tumour necrosis factor (TNF) . Positive_regulation NFKB1 STK39 11945026 930024 The , IKK beta , can *mediate* [NF- kappa B] activation although several alternative pathways exist . Positive_regulation NFKB1 TGM2 15471861 1342452 We found that *activates* the transcriptional activator [nuclear factor (NF)-kappaB] and thereby enhances LPS induced expression of inducible nitric-oxide synthase . Positive_regulation NFKB1 TGM2 16720350 1565295 Previously we showed that the overexpression of *resulted* in activation of [NF-kappaB] through polymerization of I-kappaBalpha . Positive_regulation NFKB1 TGM2 16987813 1640588 Recently we reported that *activates* [nuclear factor-kappaB (NF-kappaB)] independently of I-kappaB kinase (IKK) activation , by inducing cross linking and protein polymer formation of inhibitor of nuclear factor-kappaBalpha ( I-kappaBalpha ) . Positive_regulation NFKB1 TGM2 17108131 1645501 We recently showed that *activated* [NF-kappaB] through polymerization and depletion of free IkappaBalpha during inflammation . Positive_regulation NFKB1 TGM2 17108131 1645505 Therefore , increased expression of and subsequent *activation* of [NF-kappaB] may contribute to drug resistance in breast cancer cells independently of EGF signaling . Positive_regulation NFKB1 TGM2 18923241 1977478 The objective of the present study was to investigate the expression of in the human atherosclerotic human coronary artery , and the possible *roles* of TGase 2 in [NF-kappaB] activation . Positive_regulation NFKB1 TGM2 18950638 1989224 Furthermore , expression synergistically *increases* [NF-kappaB] activity with canonical pathway . Positive_regulation NFKB1 TLR7 11909531 923648 MyD88 is an adaptor protein that is involved in interleukin-1 receptor (IL-1R)- and *induced* activation of [NF-kappaB] . Positive_regulation NFKB1 TLR7 11937546 928142 IL-1R associated kinase (IRAK) plays a pivotal role in mediated signaling and [NF-kappaB] *activation* . Positive_regulation NFKB1 TLR7 12133979 967114 Moreover , various ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* [NF-kappa B] activation and up-regulated TNF-alpha production in osteoclast precursor cells . Positive_regulation NFKB1 TLR7 12471095 1023008 A dominant negative form of TRIF inhibited TLR2- , TLR4- , and *dependent* [NF-kappaB] activation . Positive_regulation NFKB1 TLR7 12792852 1097915 After stimulation , recruits IL-1R associated kinase via adaptor myeloid differentiation factor 88 ( MyD88 ) and *induces* activation of [NF-kappaB] and mitogen activated protein kinases . Positive_regulation NFKB1 TLR7 12885415 1116662 MyD88 ( S ) is not able to activate NF-kappaB , and in contrast functions as a dominant negative inhibitor of induced [NF-kappaB] *activation* . Positive_regulation NFKB1 TLR7 15330257 1287687 Upon stimulation , recruits a cytoplasmic adaptor molecule MyD88 , then IL-IR associated kinase (IRAK) , and finally *induces* activation of [NF-kappaB] and MAP kinases . Positive_regulation NFKB1 TLR7 16008344 1431348 Additionally , *dependent* [NF-kappaB] translocation in astrocytes appears to be blocked by gelsolin . Positive_regulation NFKB1 TLR7 16052631 1442011 Cytosolic components of NADPH oxidase suppressed mediated [NF-kappaB] *activation* as well as IFN-beta promoter activation . Positive_regulation NFKB1 TLR7 16244651 1476894 Furthermore , epithelial cell-surface hyaluronan was protective against apoptosis , in part , through *dependent* basal activation of [NF-kappaB] . Positive_regulation NFKB1 TLR7 16325814 1490964 gAd mediated inhibition of *mediated* IkappaB phosphorylation and [NF-kappaB] activation was eliminated by the pretreatment of cycloheximide . Positive_regulation NFKB1 TLR7 16457754 1522427 The activation *induce* the [NF-kappaB] translocation to the nucleus and cytokine secretion . Positive_regulation NFKB1 TLR7 16643855 1557049 Overexpression and knockdown by siRNA indicated that ZCCHC11 functions as a negative regulator of mediated [NF-kappaB] *activation* . Positive_regulation NFKB1 TLR7 16757890 1571935 These observations suggest that immediate response of NODs to endotoxins could result from [NF-kappaB] *activation* via signaling , whereas the second rise in NOD mRNAs might have resulted from TNF-alpha production possibly through NF-kappaB , TLR , and/or NOD signalings . Positive_regulation NFKB1 TLR7 16894359 1601059 Lung epithelial cell overexpression of high molecular mass HA protected mice against acute lung injury and apoptosis , in part through *dependent* basal activation of [NF-kappaB] . Positive_regulation NFKB1 TLR7 16930560 1627220 In this review we will summarize the current knowledge of mediated [NFkappaB] *activation* , and also the recent discoveries that subtle differences in kappaB binding sequences and NFkappaB dimer formation result in specific gene expression profiles . Positive_regulation NFKB1 TLR7 17100624 1644731 In the intestine , *dependent* activation of [NF-kappaB] plays a vital role in maintaining epithelial homeostasis as well as regulating infections and inflammation , while dysregulation of TLR signaling is associated with the pathogenesis of inflammatory bowel diseases (IBD) . Positive_regulation NFKB1 TLR7 17349209 1708006 Many of the key molecular events required for induced [NF-kappaB] *activation* have been elucidated . Positive_regulation NFKB1 TLR7 17462920 1743250 We demonstrated that pathogens trigger DC-SIGN on human DCs to activate the serine and threonine kinase Raf-1 , which subsequently leads to acetylation of the NF-kappaB subunit p65 , but only after induced *activation* of [NF-kappaB] . Positive_regulation NFKB1 TLR7 17475882 1738496 We conclude that bacteria induced experimental colitis involves the activation of *induced* [NF-kappaB] signaling derived mostly from mucosal immune cells . Positive_regulation NFKB1 TLR7 17475882 1738516 Blocking *induced* [NF-kappaB] activity may represent an attractive strategy to treat immune mediated intestinal inflammation . Positive_regulation NFKB1 TLR7 17724128 1789790 Microarray analysis showed that Trib1-deficient macrophages exhibited a dysregulated expression pattern of lipopolysaccharide-inducible genes , whereas mediated *activation* of MAP kinases and [NF-kappaB] was normal . Positive_regulation NFKB1 TLR7 17785851 1790791 IL-1R associated kinase (IRAK)-1 is a critical mediator of induced *activation* of the transcription factor [NF-kappaB] . Positive_regulation NFKB1 TLR7 18025224 1827720 Using gene knockout mice and siRNA to silence mouse genes , we showed that both TLR2 and are *essential* for the induction of [NFkappaB] containing genes and NFkappaB-IFN-sensitive response element ( ISRE ) cocontaining genes by either P. gingivalis or its purified components . Positive_regulation NFKB1 TLR7 18079163 1874544 IRAK-4 dependent degradation of IRAK-1 is a negative feedback signal for mediated [NF-kappaB] *activation* . Positive_regulation NFKB1 TLR7 18079163 1874576 the autophosphorylation of IRAK-1 is not necessary to terminate the induced *activation* of [NF-kappaB] . Positive_regulation NFKB1 TLR7 18345001 1886590 TRIM30 alpha negatively regulates mediated [NF-kappa B] *activation* by targeting TAB2 and TAB3 for degradation . Positive_regulation NFKB1 TLR7 18345001 1886627 TRIM30alpha promoted the degradation of TAB2 and TAB3 and inhibited [NF-kappaB] activation *induced* by signaling . Positive_regulation NFKB1 TLR7 18345001 1886648 Our results collectively indicate that TRIM30alpha negatively regulates mediated [NF-kappaB] *activation* by targeting degradation of TAB2 and TAB3 by a ` feedback ' mechanism . Positive_regulation NFKB1 TLR7 18347055 1898397 The sites of IRAK-1 ubiquitination were mapped to Lys134 and Lys180 , and arginine substitution of these residues impaired mediated IRAK-1 ubiquitination , NEMO binding , and [NF-kappaB] *activation* . Positive_regulation NFKB1 TLR7 18617174 2019971 activation *results* in nuclear translocation of the transcription factor [Nuclear Factor-kappa B (NF-kappaB)] that controls the transcription of many inflammatory genes . Positive_regulation NFKB1 TLR7 18644884 1960201 Taken together , our results demonstrate that Campylobacter induced IL-8 secretion requires functional flagella and CDT and depends on the *activation* of [NF-kappaB] through signaling and CDT in human intestinal epithelial cells . Positive_regulation NFKB1 TLR7 18794297 1986466 Two parallel interleukin-1 (IL-1) mediated signaling pathways have been uncovered for mediated [NFkappaB] *activation* : TAK1 dependent and MEKK3 dependent pathways , respectively . Positive_regulation NFKB1 TLR7 18794297 1986492 Deletion analysis of IRAK4 indicates the essential structural role of the IRAK4 death domain in receptor proximal signaling for mediating *induced* [NFkappaB] activation . Positive_regulation NFKB1 TLR7 19043549 1998917 This enhanced response involved [NF-kappaB] *activation* by signaling as well as Nod1 and Nod2 detection of type IV secretion . Positive_regulation NFKB1 TLR7 19393720 2082062 At the molecular level , beta-glucan suppressed mediated [NF-kappaB] *activation* , which may be responsible for the diminished capacity of microglia to produce cytokines in response to TLR stimulation . Positive_regulation NFKB1 TLR7 19439083 2090454 *Activation* of the transcription factor [NFkappaB] through following bacterial infection is principally involved in regulating lung inflammation in CF . NFkappaB regulates the transcription of several genes that are involved in inflammation , anti-apoptosis and anti-microbial activity , and hyper-activation of this transcription factor leads to a potent inflammatory response . Positive_regulation NFKB1 TLR7 19494276 2091523 Reporter analyses demonstrated that mediated [NF-kappaB] *activation* was higher in Trim21 ( -/- ) cells than in wild-type cells , most likely accounting for their enhanced cytokine expression . Positive_regulation NFKB1 TLR7 19521662 2108909 Transforming growth factor-beta activated kinase 1 ( TAK1 ) is a serine/threonine protein kinase that is critically involved in the *activation* of [NF-kappaB] by tumor necrosis factor ( TNFalpha ) , interleukin-1beta (IL-1beta) and ligands . Positive_regulation NFKB1 TLR7 19679103 2132893 Importantly , the TLR3 ligand , as well as other ligands , significantly *promoted* the expression of proinflammatory cytokines and the activation of [NF-kappaB] by LRRC19 . Positive_regulation NFKB1 TLR7 19719951 2133673 [Nuclear factor-kappa B (NF-kappaB)] regulates many genes essential for inflammation and immunity and is *activated* by . Positive_regulation NFKB1 TLR7 19796680 2183889 These same ligand *induced* [NFkappaB] responses are not observed in TLR deficient HEK293 cells , but are re-established in HEK293 cells stably transfected with TLR4/MD2 , and are significantly inhibited by alpha-2,3-sialyl specific Maackia amurensis ( MAL-2 ) lectin , alpha-2,3-sialyl specific galectin-1 and neuraminidase inhibitor Tamiflu but not by alpha-2,6-sialyl specific Sambucus nigra lectin ( SNA ) . Positive_regulation NFKB1 TLR7 19913487 2166493 Both proteins interact with IRAK2 and TRAF6 and suppress *dependent* [NF-kappaB] activation . Positive_regulation NFKB1 TLR7 19933851 2172019 Specifically , we demonstrate the Siglec-E expression inhibits *induced* [NF-kappaB] and more importantly , the induction of the antiviral cytokines IFN-beta and RANTES . Positive_regulation NFKB1 TLR7 20308556 2238092 Using HEK293 cells transfected with murine TLR7 or TLR8 and a NF-kappaB luciferase reporter , we demonstrated that stimulation of TLR8- , but not , transfected cells with either VV or VV DNA *resulted* in substantial [NF-kappaB] activation , and that siRNA mediated knockdown of TLR8 expression in pDCs led to a complete ablation of VV-induced type I IFN production . Positive_regulation NFKB1 TLR7 20385024 2261932 Also , the suppressive effect of triptolide on *induced* [NFkappaB] activation was observed when either MyD88 or TRIF was knocked out , confirming that both MyD88 and TRIF mediated NFkappaB activation may be inhibited by triptolide . Positive_regulation NFKB1 TLR7 20584979 2303305 These experiments reveal a novel PDK-1 dependent negative feedback inhibition of induced [NF-kappaB] *activation* in macrophages in vivo . Positive_regulation NFKB1 TLR7 20702732 2312677 We present a functional analysis of zebrafish Myd88 and Tirap and suggest that Myd88 is more important than Tirap for the activation of *mediated* [NF-kappaB] , which may be a novel mechanism of Myd88 dependent TLR signaling in teleosts . Positive_regulation NFKB1 TLR7 20816209 2314899 Notably , DC-SIGN triggering by these pathogens results in a specific Raf-1 dependent signaling pathway that modulates *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 10022904 590577 Previous studies have demonstrated that the atypical PKCs are stimulated by and are *required* for the activation of [NF-kappaB] by this cytokine through a mechanism that most probably involves the phosphorylation of IkappaB . Positive_regulation NFKB1 TNF 10029619 591692 *stimulated* [NF-kappaB] activation and nuclear translocation and the degradation of Ikappa-Balpha were blocked by mesalamine . Positive_regulation NFKB1 TNF 10037458 592124 The PKC inhibitor calphostin C inhibited [NF-kappaB] *activation* by or interleukin (IL)-1beta in Jurkat or NIH3T3 cells but not in MCF7 A/Z cells . Positive_regulation NFKB1 TNF 10063910 593328 induced *activation* of [NF-kappaB] activity was suppressed by NAC , and H2O2 caused significant activation of NF-kappaB . Positive_regulation NFKB1 TNF 10072079 594382 Conversely , expression of kinase-deficient Cot inhibits CD3/CD28 but not *induction* of [NF-kappaB] . Positive_regulation NFKB1 TNF 10075662 594898 Activation of [NF-kappaB] by RANK *requires* receptor associated factor ( TRAF) 6 and NF-kappaB inducing kinase . Positive_regulation NFKB1 TNF 10079106 595517 Specific inhibitors of p38alpha MAPk blocked LPS induced adhesion , [nuclear factor-kappa B (NF-kappaB)] *activation* , and synthesis of . Positive_regulation NFKB1 TNF 10082424 597720 induces apoptosis in confluent LLC-PK1 epithelial cells , but also *activates* [NF-kappaB] , a negative regulator of apoptosis . Positive_regulation NFKB1 TNF 10085086 599323 *induces* Bcl-2 and Bcl-x expression through [NFkappaB] activation in primary hippocampal neurons . Positive_regulation NFKB1 TNF 10089130 599977 Phospholipase A2 inhibitors and leukotriene synthesis inhibitors block induced [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 10089130 599981 The role , however , of AA and its metabolites in *induced* [NF-kappaB] activation is still obscure . Positive_regulation NFKB1 TNF 10092612 600595 Unlike lipopolysaccharide , C2-ceramide failed to activate [NF-kappaB] and did not *induce* production of or interleukin-6 . Positive_regulation NFKB1 TNF 10102704 602366 The augmented induced [NF-kappaB] *activation* in HG was associated with increased TNF-alpha mediated transcriptional activation of the vascular cell adhesion molecule-1 promoter . Positive_regulation NFKB1 TNF 10187765 602511 Tumor necrosis factor alpha (TNFalpha) also stimulated increased PI 3-kinase activity , however *stimulated* [NF-kappaB] activation was not affected by the PI 3-kinase inhibitors or the p85 dominant negative mutant . Positive_regulation NFKB1 TNF 10187861 603062 Furthermore , tumor necrosis factor-alpha activated endogenous TAK1 , and the kinase negative TAK1 acted as a dominant negative inhibitor against induced [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 10192291 603645 These DOTMA/DOPE induced changes were not due to alterations in VCAM-1 mRNA stability , nor did DOTMA/DOPE inhibit *induced* [NF-kappaB-like] binding activity in nuclear extracts of HPAEC , as analyzed by electrophoretic mobility shift assay . Positive_regulation NFKB1 TNF 10195895 604127 In contrast , there was no impairment of [NF-kappaB] activation *induced* by either interleukin-1 or in IKKalpha-deficient embryonic fibroblasts and thymocytes , indicating that IKKalpha is not essential for cytokine induced activation of NF-kappaB . Positive_regulation NFKB1 TNF 10195897 604189 Mouse embryonic fibroblast cells that were isolated from IKK2-/- embryos showed a marked reduction in tumor necrosis factor-alpha (TNF-alpha)- and interleukin-1alpha induced [NF-kappaB] activity and an enhanced apoptosis in *response* to . Positive_regulation NFKB1 TNF 10196356 604660 Previous studies in airway epithelial cells demonstrated that *induced* [NF-kappaB] activation is transient due to regulation by IkappaBalpha . Positive_regulation NFKB1 TNF 10196356 604666 Thus , while manipulation of IkappaBalpha results in reversal of *induced* [NF-kappaB] activation , manipulation of IkappaBalpha does not result in a reversal of RSV induced NF-kappaB activation . Positive_regulation NFKB1 TNF 10199558 605269 NaS decreased *stimulated* [NFkappaB] activation by 50 % as assessed by EMSA . Positive_regulation NFKB1 TNF 10199816 605360 These effects of lactacystin and PS-341 were associated with inhibitory effects on *stimulated* [NF-kappaB] activation in both HUVEC and ECV . Positive_regulation NFKB1 TNF 10199816 605362 Our results demonstrate the importance of the 26S proteasome in *induced* activation of [NF-kappaB] , ECAM expression , and leukocyte-endothelial adhesive interactions in vitro . Positive_regulation NFKB1 TNF 10201927 605680 Our observations support the notion that full LPS response of gene *requires* both [NF-kappaB] and non-NF-kappaB nuclear proteins . Positive_regulation NFKB1 TNF 10201951 605703 These data suggest that in fibroblasts activates and *initiates* the nuclear translocation of [NF-kappa B] that binds a divergent NF-kappa B element and plays a critical role in the observed inhibition of alpha 2 ( I ) collagen gene transcription . Positive_regulation NFKB1 TNF 10201981 605768 We characterized the effect of a dominant negative TRAF-2 delivered by an adenoviral vector ( Ad5dnTRAF-2 ) on the cytokine signaling cascade in several IEC and also investigated whether inhibiting the TRAF-2 transmitting signal blocked *induced* [NF-kappa B] and IL-8 gene expression . Positive_regulation NFKB1 TNF 10210266 607490 In the present study , [NF-kappaB] was *activated* by in rat aortic smooth muscle cells as demonstrated by electrophoretic mobility shift assay . Positive_regulation NFKB1 TNF 10210266 607494 The activity of [NF-kappaB] *induced* by was blocked by calpain inhibitor I , a potent NF-kappaB inhibitor . Positive_regulation NFKB1 TNF 10218970 608578 Both IL-1beta and *activated* [nuclear factor (NF)-kappaB] as demonstrated by electrophoretic mobility shift assay . Positive_regulation NFKB1 TNF 10222332 609619 Under these conditions , *induced* [NF-kappaB] nuclear translocation and DNA binding were inhibited , NF-kappaB dependent luciferase activity was reduced by 50 % , there was no degradation of native IkappaBalpha detected , interleukin-6 production was reduced by 54 % , and VSMC proliferation was decreased by 60 % . Positive_regulation NFKB1 TNF 10224110 609993 PG490 potently inhibited *induced* activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 10224110 609997 Our identification of a compound that blocks induced *activation* of [NF-kappaB] may enhance the cytotoxicity of TNF-alpha on tumors in vivo and limit its proinflammatory effects . Positive_regulation NFKB1 TNF 10226064 610329 In contrast , *activated* [NF-kappaB] in a Ras independent fashion . Positive_regulation NFKB1 TNF 10226064 610331 Evaluation of members of the mitogen activated protein kinase (MAPK) family as downstream effectors of Ras revealed the requirement of MAPK/ extracellular regulated kinase (ERK) kinase kinase ( MEKK)1 and c-Jun N-terminal kinases in the *induction* of [NF-kappaB] by both oxidants and , whereas the MEK-ERK pathway negatively regulates NF-kappaB . Positive_regulation NFKB1 TNF 10232679 611402 Treatment with N ( G ) -nitro-L-arginine methyl ester ( L-NAME ) did not affect initial *activation* of [NF-kappaB] by , but unveiled an inhibitory effect of NO generation on NF-kappaB activity after 4 h . Positive_regulation NFKB1 TNF 10318796 611880 Pretreating Mo7e cells with SN50 blocked *induced* nuclear translocation of [NF-kappaB] and inhibited TNF-alpha induced Mo7e cell survival and proliferation . Positive_regulation NFKB1 TNF 10336463 615453 Similarly , RAI inhibited the endogenous [NF-kappaB] activity *induced* by . Positive_regulation NFKB1 TNF 10340762 616210 We studied the kinetics of [NF-kappaB] *induction* by in primary astrocytes , and in the neuroblastoma cell line Neuro2A , and compared it to fibroblasts . Positive_regulation NFKB1 TNF 10342828 616511 Treatment of the cells with 17beta-E2 partially suppressed the *activation* of [NF-kappaB] by , but did not block cytokine induced IL-6 secretion . Positive_regulation NFKB1 TNF 10346820 616689 [NF-kappaB] activation *mediated* by and IL-1 is diminished in IKK1-deficient mouse embryonic fibroblast (MEF) cells . Positive_regulation NFKB1 TNF 10361130 619765 This contrasts with *dependent* [NF-kappaB] activation , which occurs earlier , involves p65/p50 dimers , and is dependent on IkappaB degradation . Positive_regulation NFKB1 TNF 10364242 620525 Expression of the CARD domain of human CLAP abrogates *induced* [NF-kappaB] activation , suggesting that cellular CLAP plays an essential role in this pathway of NF-kappaB activation . Positive_regulation NFKB1 TNF 10364831 621105 Here we show that micromolar concentrations of hypericin inhibited the PMA- and *induced* activation of [NF-kappa B] in HeLa and TC10 cells , respectively . Positive_regulation NFKB1 TNF 10376811 623513 However , PDTC did not inhibit *induced* [NF-kappaB] DNA binding activity but potentiated the effect of TNF-alpha on kappaB dependent gene expression . Positive_regulation NFKB1 TNF 10383449 624583 The human tumor necrosis factor (TNF) receptor associated factor 1 gene ( TRAF1 ) is up-regulated by cytokines of the TNF ligand family and modulates *induced* activation of [NF-kappaB] and c-Jun N-terminal kinase . Positive_regulation NFKB1 TNF 10383449 624597 In fact , we found that TNF induced activation of JNK is prolonged in transfectants overexpressing TRAF1 , whereas overexpression of a deletion mutant of TRAF1 in which the N-terminal part had been replaced by the green fluorescent protein interfered with *induced* activation of [NF-kappaB] and JNK . Positive_regulation NFKB1 TNF 10385418 625464 *induced* [NF-kappaB] activation in both primary islet cells and NIT-1 cells . Positive_regulation NFKB1 TNF 10385526 625571 We show that A20 does not inhibit *induced* nuclear translocation and DNA binding of [NF-kappaB] , although it completely prevents the TNF- induced activation of an NF-kappaB dependent reporter gene , as well as TNF induced IL-6 and granulocyte macrophage-colony stimulating factor gene expression . Positive_regulation NFKB1 TNF 10385526 625575 Moreover , [NF-kappaB] activation *induced* by overexpression of the receptor associated proteins TNF receptor associated death domain protein ( TRADD ) , receptor interacting protein ( RIP ) , and TNF recep- tor associated factor 2 ( TRAF2 ) was also inhibited by expression of A20 , whereas NF-kappaB activation induced by overexpression of NF-kappaB inducing kinase (NIK) or the human T cell leukemia virus type 1 ( HTLV-1 ) Tax was unaffected . Positive_regulation NFKB1 TNF 10391885 626760 IkappaBalphaM was resistant to stimulus dependent degradation and suppressed [NF-kappaB] activation *induced* by ( 10 ng/ml ) or IL-1beta ( 10 ng/ml ) . Positive_regulation NFKB1 TNF 10391896 626782 [NF-kappaB] *activation* by provides a survival signal that impairs the TNFalpha induced apoptotic response . Positive_regulation NFKB1 TNF 10391896 626786 In addition , the down-regulation of Par-4 levels by oncogenic Ras sensitizes cells to *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 10404391 629264 Several lines of evidence suggest that *activates* transcription factor [nuclear factor-kappa B (NF kappa B)] through activation of protein kinase C ( PKC ) or the hydrolysis of sphingomyelin to ceramide in a number of cell types . Positive_regulation NFKB1 TNF 10409708 630328 The p75 neurotrophin receptor (p75NTR) alters mediated NF-kappaB activity under physiological conditions , but direct p75NTR mediated [NF-kappaB] activation *requires* cell stress . Positive_regulation NFKB1 TNF 10409708 630332 All cell types showed mediated *activation* of [NF-kappaB] , but direct neurotrophin dependent activation of NF-kappaB was never observed under normal growth conditions . Positive_regulation NFKB1 TNF 10409708 630342 Although NGF binding did not directly activate NF-kappaB under normal conditions , NGF consistently altered dependent [NF-kappaB] *activation* in each cell type examined , and extended exposure to NGF and TNF always increased NF-kappaB activation over that achieved with TNF alone . Positive_regulation NFKB1 TNF 10414954 631097 receptor activation *results* in activation of the transcription factor [nuclear factor kappaB (NF-kappaB)] , which may serve an antiapoptotic role via the induction of target genes manganese superoxide dismutase ( MnSOD ) and/or calbindin . Positive_regulation NFKB1 TNF 10416616 631442 *Induction* of [NF-kappaB] by was inhibited by the addition of protease inhibitors calpain inhibitor I and N-tosyl-phechloromethyl ketone and antioxidant 1-pyrrolidinecarbodithioic acid , whereas constitutive activation of NF-kappaB and cytokine KC mRNA expression was inhibited by N-tosyl-phechloromethyl ketone alone . Positive_regulation NFKB1 TNF 10416616 631444 Overexpression of a human Ikappa(B)alpha dominant suppresser in Pam 212 cells inhibited *induced* [NF-kappaB] binding activity and KC expression . Positive_regulation NFKB1 TNF 10416616 631446 These data indicate that activation of NF-kappaB contributes to increased expression of proinflammatory cytokines during metastatic tumor progression of squamous cell carcinoma , and that distinct mechanisms may be involved in the regulation of constitutive and *induced* activation of [NF-kappaB] in squamous cell carcinoma . Positive_regulation NFKB1 TNF 10416957 631452 In addition , it has been established that can *activate* the expression of wild type p53 in concert with the nuclear transcription factor , [NF-kappa B] . Positive_regulation NFKB1 TNF 10419449 631725 Since activation of nuclear factor kappaB (NF-kappaB) has been shown to play an anti-apoptotic role in TNF induced apoptosis , we examined apoptotic susceptibility and [NF-kappaB] activation *induced* by in the E1A transfectants and their parental cells . Positive_regulation NFKB1 TNF 10428782 633243 Cell stress and MKK6b mediated p38 MAP kinase activation inhibit induced IkappaB phosphorylation and [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 10428782 633279 Thus , sustained p38 activation by various stimuli inhibits *induced* IkappaB phosphorylation and [NF-kappaB] activation . Positive_regulation NFKB1 TNF 10430178 633567 IL-1beta and *stimulated* nuclear [NF-kappaB] levels by about fourfold and fivefold , respectively , in HASMCs . Positive_regulation NFKB1 TNF 10438843 635059 is the major *inducer* of [NF-kappaB] and particularly of the p50-p65 complex , whereas IL-7 acts as a cofactor by sustaining the expression of the p75 TNF receptor . Positive_regulation NFKB1 TNF 10438953 635170 Using EMSA , we show that stimulation with or IL-1 beta *induces* [NF-kappa B] DNA binding activity in human airway smooth muscle cells . Positive_regulation NFKB1 TNF 10438953 635178 In cells transfected with the luciferase reporter , dexamethasone did not affect *induced* [NF-kappa B-dependent] transcription . Positive_regulation NFKB1 TNF 10439045 635222 Transfection of cells with gamma-GCS cDNA blocked *induced* [NF-kappa B] activation , cytoplasmic I kappa B alpha degradation , nuclear translocation of p65 , and NF-kappa B-dependent gene transcription . Positive_regulation NFKB1 TNF 10440583 635388 The role of superoxide radical in *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 10440583 635398 02*- seems to play a key role in *induced* [NF-kappaB] activation in macrophages . Positive_regulation NFKB1 TNF 10440583 635400 Xanthine and xanthine oxidase appears to be a source of O2*- radicals responsible for induced [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 10447681 636981 Pervanadate induced tyrosine phosphorylation increased the induced cytotoxicity and [NF-kappaB] *activation* , suggesting that it stimulates early signaling events prior to the separation of the two signaling pathways . Positive_regulation NFKB1 TNF 10449775 637410 *Activation* of either [NF-kappaB] or c-Jun NH ( 2 ) -terminal kinase/stress activated protein kinase by , CD27 , and CD40 was not abrogated in traf5 ( -/- ) mice . Positive_regulation NFKB1 TNF 10455154 638574 We also found that *induced* activation of [NF-kappaB] did not account for the enhanced TNF susceptibility by E6 . Positive_regulation NFKB1 TNF 10477576 643048 rapidly *induced* marked activation of nuclear transcription factor [NF-kappa B] in all 4 cell lines . Positive_regulation NFKB1 TNF 10477716 643259 treatment *induces* a rapid translocation of the 65 kD transcriptional activator [NF-kappaB] subunit , Rel A , whose binding in the nucleus occurs before changes in intracellular ROS . Positive_regulation NFKB1 TNF 10484327 643965 Quercetin had no effect on PMA- or *induced* [nuclear factor-kappaB (NF-kappaB)] activation . Positive_regulation NFKB1 TNF 10485710 644425 Here we show that the Akt serine-threonine kinase is involved in the *activation* of [NF-kappaB] by . Positive_regulation NFKB1 TNF 10485710 644512 Wortmannin ( a PI(3)K inhibitor ) , dominant negative PI(3)K or kinase-dead Akt inhibits mediated [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 10485710 644545 Mutation of this amino acid blocks phosphorylation by Akt or and *activation* of [NF-kappaB] . Positive_regulation NFKB1 TNF 10490923 645813 [NF-kappaB] activation in *response* to , IL-1beta , phorbol ester , and H ( 2 ) O ( 2 ) was down-regulated by polaprezinc . Positive_regulation NFKB1 TNF 10490994 645859 The factor had no effect on TNF induced cytotoxicity , but abrogated *induced* [NF-kappa B] activation . Positive_regulation NFKB1 TNF 10524940 653864 In normal human urothelial cells , activation of the [NF-kappaB] complex in *response* to stimulation with , LPS , and dsRNA was detected by immunohistochemical methods and EMSA . Positive_regulation NFKB1 TNF 10532402 562327 Involvement of reactive oxygen species in *mediated* activation of the transcription factor [NF-kappaB] in canine dermal fibroblasts . Positive_regulation NFKB1 TNF 10532402 562329 With respect to a possible therapeutic modulation of *mediated* activation of [Nuclear Factor-kappa B (NF-kappaB)] in canine cutaneous inflammation , we investigated the role of NF-kappaB and the involvement of reactive oxygen species ( ROS ) in the TNF-alpha signalling pathway in dermal fibroblasts of the dog . Positive_regulation NFKB1 TNF 10540155 563253 The EMSAs indicated that sodium butyrate suppressed *induced* [nuclear factor (NF)-kappaB-] and activation protein (AP)-1-DNA binding activity , but enhanced TNF-alpha induced activation of CCAAT/enhancer binding protein ( C/EBP)beta (NF-IL-6 ) -DNA binding activity . Positive_regulation NFKB1 TNF 10541434 563491 Fibrosis is frequently associated with inflammation , which is accompanied by increased levels of and *activation* of the transcription factor [NF-kappaB] . Positive_regulation NFKB1 TNF 10544244 564084 Interestingly , overexpression of TRAF1 in HEK293T completely prevented [NF-kappaB] activation *induced* by , IL-1 , or overexpression of TRAF2 or TRAF6 . Positive_regulation NFKB1 TNF 10544256 564099 Using electrophoretic mobility shift assays , we found that not only but also interleukin-1beta and parathyroid hormone (PTH) *caused* dose and time related increases in [nuclear factor kappaB (NF-kappaB)-DNA] binding in Saos-2 human osteoblastic ( hOB ) cells . Positive_regulation NFKB1 TNF 10544256 564107 *Activation* of [NF-kappaB] by was reproduced in primary hOBs . Positive_regulation NFKB1 TNF 10559511 566622 Angiotensin II (Ang II) and *increased* [NF-kappaB] activity in VSMC ( 2 and 5-fold , respectively ) . Positive_regulation NFKB1 TNF 10564241 567198 These results suggest that *contributes* , in part , to changes in interstitial volume , myofibroblast differentiation , and [NF-kappaB] activation in the kidney during ureteral obstruction . Positive_regulation NFKB1 TNF 10567330 567623 In contrast , *induced* [NF-kappaB] activation occurred in concert with degradation of IkappaBalpha . Positive_regulation NFKB1 TNF 10567330 567625 Inhibition of IkappaBalpha degradation with a proteasome inhibitor , MG-115 , blocked [NF-kappaB] activation *induced* by ; Positive_regulation NFKB1 TNF 10580148 570008 Overexpression of AZ2 inhibited *mediated* [NFkappaB] activation . Positive_regulation NFKB1 TNF 10580567 570095 RPMI-8226 cells showed [NF-kappaB] *activation* by , but contrary to OH-2 , not by CH11 . Positive_regulation NFKB1 TNF 10581242 570228 We find can *activate* the nuclear [IkappaBalpha-NF-kappaB] complexes by the classical mechanism of proteasome mediated degradation of IkappaBalpha . Positive_regulation NFKB1 TNF 10585438 571394 Stimulation of Sertoli cells with , an NF-kappaB activating cytokine produced by round spermatids located adjacent to Sertoli cells , *stimulated* the elimination of IkappaB , the translocation of additional NF-kappaB to the nucleus , and increased [NF-kappaB] binding to CREB promoter kappaB enhancer elements . Positive_regulation NFKB1 TNF 10586080 571794 Silymarin suppresses *induced* activation of [NF-kappa B] , c-Jun N-terminal kinase , and apoptosis . Positive_regulation NFKB1 TNF 10586080 571796 Silymarin blocked induced *activation* of [NF-kappa B] in a dose- and time dependent manner . Positive_regulation NFKB1 TNF 10593965 572901 *stimulated* [nuclear factor (NF) kappaB] activation plays a key role in the pathogenesis of inflammatory bowel disease (IBD) . Positive_regulation NFKB1 TNF 10604572 575044 GalN treatment failed to affect *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 10615065 656333 however , *induced* both AP-1 and [NF-kappaB] binding activities in BET-1A cells . Positive_regulation NFKB1 TNF 10619864 657392 However , [NF-kappaB] activation and IL-8 secretion *induced* by S. typhimurium , but not by , was preceded by and required an increase in intracellular [ Ca ( 2+ ) ] . Positive_regulation NFKB1 TNF 10623427 576187 IL-8 and LIF had no effect on the *induced* [NF-kappaB] accumulation , while IL-11 significantly decreased it ( P < 0. 02 ) . Positive_regulation NFKB1 TNF 10623598 658133 TGF-beta induced matrix proteins inhibit p42/44 MAPK and JNK activation and suppress *mediated* IkappaBalpha degradation and [NF-kappaB] nuclear translocation in L929 fibroblasts . Positive_regulation NFKB1 TNF 10625622 658569 In contrast , although *activated* [NF-kappaB] transcription , E5510 had no effect on TNF-alpha induced activation . Positive_regulation NFKB1 TNF 10625622 658581 NF-kappaB was activated after the stimulation of TRAP , bFGF , and TNF-alpha in electrophoretic mobility shift assay , and E5510 suppressed the [NF-kappaB] activation induced by TRAP and bFGF but not the *activation* by . Positive_regulation NFKB1 TNF 10640750 660641 Phosphatidylinositol 3-kinase as a mediator of induced [NF-kappa B] *activation* . Positive_regulation NFKB1 TNF 10640750 660645 The *activation* of transcription factor [NF-kappa B] by involves the stimulation of a novel signaling cascade . Positive_regulation NFKB1 TNF 10640750 660647 In this paper we show that phosphatidylinositol 3-kinase ( PI 3-kinase ) may play a pivotal role in *mediated* activation of [NF-kappa B-dependent] genes . Positive_regulation NFKB1 TNF 10640750 660654 A dominant negative mutant of the p85 regulatory subunit of PI 3-kinase , which is a potent inhibitor of PI 3-kinase signaling , effectively blocked the *induced* expression of an [NF-kappa B-dependent] reporter gene . Positive_regulation NFKB1 TNF 10644576 661110 Human hepatoma cell lines were used to investigate the effectiveness and specificity of the fungal metabolite gliotoxin in inhibiting *induced* [NF-kappaB] activation in transformed cells . Positive_regulation NFKB1 TNF 10644980 661661 Induction of p21Waf1/Cip1 by *requires* [NF-kappaB] activity and antagonizes apoptosis in Ewing tumor cells . Positive_regulation NFKB1 TNF 10644980 661669 Our results therefore identify p21Waf1/Cip1 as a mediator of the antiapoptotic effect of *induced* [NF-kappaB] in Ewing tumor cells . Positive_regulation NFKB1 TNF 10671572 667272 Both DNA binding assays and luciferase assays revealed that *induced* [NF-kappaB] activation is defective in T2 cells . Positive_regulation NFKB1 TNF 10677219 668079 On the other hand , is a strong *activator* of [NF-kappa B] whereas sorbitol is not . Positive_regulation NFKB1 TNF 10692572 671229 The C-terminal cleavage product blocks the *induction* of [NF-kappaB] by and therefore functions as a dominant negative ( DN ) form of TRAF1 . Positive_regulation NFKB1 TNF 10692573 671231 We show that the serine/threonine kinase RIP that is required for *induced* [NF-kappaB] activation is processed by caspase-8 into a dominant negative ( DN ) fragment during death receptor induced apoptosis , thereby leading to a blockade of NF-kappaB mediated anti-apoptotic signals . Positive_regulation NFKB1 TNF 10700573 672417 Sodium valproate inhibits production of and IL-6 and *activation* of [NF-kappaB] . Positive_regulation NFKB1 TNF 10704251 672816 Pretreatment with either compound inhibited *mediated* activation of the IL-8 promoter and TNF-alpha mediated nuclear translocation of [NF-kappaB] . Positive_regulation NFKB1 TNF 10707928 673456 In PANC-1 cells , IL-1beta and *induced* a rapid activation of [nuclear factor (NF)-kappaB] , and TGF-beta1 enhanced this activation slightly . Positive_regulation NFKB1 TNF 10725745 677657 Phosphorylation of p42 and p44 MAPKs , which can be prevented by a mitogen activated protein/extracellular signal related kinase kinase-1 inhibitor , peaks by 15-20 min and largely disappears by 40 min . IL-11 does not activate NF-kappaB nor does it inhibit [NF-kappaB] *activation* by . Positive_regulation NFKB1 TNF 10727667 678081 High glucose or mannitol also enhanced *stimulated* [NF-kappaB] activity . Positive_regulation NFKB1 TNF 10727667 678083 An antioxidant N-acetyl-L-cysteine and a selective protein kinase C ( PKC ) inhibitor GF109203X significantly suppressed the *induced* [NF-kappaB] activation , and abrogated potentiation of TNFalpha induced NF-kappaB activity caused by high glucose ( 27.5 mmol/l ) . Positive_regulation NFKB1 TNF 10728675 678158 In the progenitor B lymphocyte model FL5.12 , whereas [NF-kappaB] has an antiapoptotic function in *response* to , cytokine withdrawal causes nuclear translocation of NF-kappaB/cRel , where it is apoptogenic . Positive_regulation NFKB1 TNF 10744037 680582 By immunocytochemical and functional assays , we found that SC expressed TNF receptors and that *promoted* in SC cultures transient activation of transcription factors [NFkappaB] and c-jun in the absence of apoptosis . Positive_regulation NFKB1 TNF 10744638 680628 Here we demonstrate that cationic liposomes containing phosphorothioated oligodeoxynucleotides ( ODN ) with the kappaB binding site serving as competitive binding decoy , can prevent *induced* [NFkappaB] activity in endothelial cells in vitro . Positive_regulation NFKB1 TNF 10744744 680744 The death domain kinase , receptor interacting protein ( RIP ) , is one of the major components of the tumor necrosis factor receptor 1 (TNFR1) complex and plays an essential role in mediated [nuclear factor kappaB (NF-kappaB)] *activation* . Positive_regulation NFKB1 TNF 10744744 680751 These data indicate that Hsp90 plays an important role in mediated [NF-kappaB] *activation* by modulating the stability and solubility of RIP . Positive_regulation NFKB1 TNF 10753878 682297 A mutant of Casper and the caspase-specific inhibitors crmA and BD-fmk partially inhibit TNF-R1- , TRADD , and *induced* [NF-kappaB] activation , suggesting that FADD , Casper , and caspase-8 function downstream of TRADD and contribute to TNF-R1 induced NF-kappaB activation . Positive_regulation NFKB1 TNF 10754482 682702 The binding activity of AP-1 was found to be stimulated by the growth inhibitory cytokines , TGF-beta1 and TNF-alpha , and the binding of [NF-kappaB] was *stimulated* by . Positive_regulation NFKB1 TNF 10755617 682783 The adapter protein RIP plays a crucial role in [NF-kappaB] *activation* by . Positive_regulation NFKB1 TNF 10759715 683217 Forskolin inactivated NF-kappaB in K/Dau600 cells but not in K562 cl. 6 cells , whereas *activated* [NF-kappaB] in K562 cl.6 cells but not in K/Dau600 cells . Positive_regulation NFKB1 TNF 10759767 683487 To examine the effects of AF and GSTM on *induced* [NF-kappaB] activation this was measured in HUVEC nuclear extracts by an electrophoretic mobility shift assay . Positive_regulation NFKB1 TNF 10759767 683499 AF , but not GSTM , decreased *induced* [NF-kappaB] activation in HUVEC . Positive_regulation NFKB1 TNF 10766741 684456 NEMO/IKKgamma-deficient primary murine embryonic fibroblasts ( MEFs ) lack detectable [NF-kappaB] DNA binding activity in *response* to , IL-1 , LPS , and Poly ( IC ) and do not show stimulus dependent IkappaB kinase activity , which correlates with a lack of phosphorylation and degradation of IkappaBalpha . Positive_regulation NFKB1 TNF 10766844 684549 The Drosophila receptor associated factor-1 ( DTRAF1 ) interacts with Pelle and *regulates* [NFkappaB] activity . Positive_regulation NFKB1 TNF 10779771 687504 Transduced Bcl-2 did not reduce mediated [NF-kappaB] *activation* or constitutive expression of class I MHC molecules . Positive_regulation NFKB1 TNF 10784415 688250 *induced* activation of transcription factor [nuclear factor-kappaB (NF-kappaB)] was observed in all 3 cell lines . Positive_regulation NFKB1 TNF 10784415 688252 Pretreatment with the known potent NF-kappaB inhibitor pyrolidine dithiocarbamate ( PDTC ) profoundly suppressed the activation of [NF-kappaB] *induced* by and potentiated TNF cytotoxicity in all 3 cell lines . Positive_regulation NFKB1 TNF 10788437 688678 Treatment of the CaCOV3 human ovarian cell line with hCG blocked *induced* activation of [NF-kappaB] , IkappaBalpha degradation , and NF-kappaB dependent reporter gene transcription . Positive_regulation NFKB1 TNF 10788610 688942 N-acetylcysteine suppresses *induced* [NF-kappaB] activation through inhibition of IkappaB kinases . Positive_regulation NFKB1 TNF 10788610 688952 NAC also suppressed the *induced* activation of IKKalpha and IKKbeta , phosphorylation and degradation of IkappaB , and nuclear translocation of [NF-kappaB] . Positive_regulation NFKB1 TNF 10795524 689670 Herpes simplex virus type 2 infection of macrophages impairs IL-4 mediated inhibition of NO production through *induced* activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 10795740 689757 To understand the mechanism by which RIP and TRAF2 regulate *induced* activation of the transcription factor [NF-kappaB] , we investigated their respective roles in TNF-R1 mediated IKK activation using both RIP-/- and TRAF2-/- fibroblasts . Positive_regulation NFKB1 TNF 10799299 691080 PI3K and AKT cell survival signaling were correlated with increased *stimulated* [NF-kappaB] activity in MCF-7 cells . Positive_regulation NFKB1 TNF 10799874 691385 These effects were specific to HIV-tat , as *activation* of [NF-kappa B] by PMA , LPS , H2O2 , and was minimally affected . Positive_regulation NFKB1 TNF 10807663 692261 Nuclear [NF-kappaB] activity was robustly *induced* by . Positive_regulation NFKB1 TNF 10815922 693558 p6R-IkappaB ( S32A + S36A ) blocked the *stimulation* of [NF-kappaB] activity by in prostate cancer cells . Positive_regulation NFKB1 TNF 10820260 694369 Vesnarinone suppresses *induced* activation of [NF-kappa B] , c-Jun kinase , and apoptosis . Positive_regulation NFKB1 TNF 10820260 694371 Vesnarinone blocked induced *activation* of [NF-kappa B] in a concentration- and time dependent manner . Positive_regulation NFKB1 TNF 10820260 694375 The effects of vesnarinone were not cell type specific , as it blocked *induced* [NF-kappa B] activation in a variety of cells . Positive_regulation NFKB1 TNF 10825233 696424 did not affect STAT1 activation , but *stimulated* DNA binding and transcriptional activity of [NF-kappaB] , both of which were further increased by IFN-gamma . Positive_regulation NFKB1 TNF 10825233 696429 In conclusion , IFN-gamma activates STAT1 and potentiates *induced* [NF-kappaB] activation in INS-1 cells , thereby inducing iNOS and cell destruction . Positive_regulation NFKB1 TNF 10839991 699642 *Activation* of endogenous [NF-kappaB] by was also able to inhibit the Smad7 promoter in human embryonic kidney 293 cells . Positive_regulation NFKB1 TNF 10843709 700166 Resveratrol blocked *induced* activation of [NF-kappaB] in a dose- and time dependent manner . Positive_regulation NFKB1 TNF 10843709 700169 Suppression of *induced* [NF-kappaB] activation by resveratrol was not restricted to myeloid cells ( U-937 ) ; Positive_regulation NFKB1 TNF 10848577 701022 As a consequence , mediated I-kappaB degradation and [NF-kappaB] *activation* were markedly enhanced in Stat1-deficient cells , whereas overexpression of Stat1 in 293T cells blocked NF-kappaB activation by TNF-alpha . Positive_regulation NFKB1 TNF 10849440 701174 TAF(II)105 , a substoichiometric coactivator subunit of TFIID , is important for activation of anti-apoptotic genes by [NF-kappaB] in *response* to the cytokine . Positive_regulation NFKB1 TNF 10851266 701595 EMSAs indicated that trichostatin A weakly suppressed *induced* [NF-kappaB] and NF-IL6 activation . Positive_regulation NFKB1 TNF 10853648 704104 DHM2EQ inhibited *induced* activation of [NF-kappaB] in human T cell leukemia cells , and also inhibited collagen induced arthritis in a rheumatoid model in mice . Positive_regulation NFKB1 TNF 10866999 722318 An activator of peroxisome proliferator activated receptor gamma , 15-deoxy-Delta ( 12,14 ) -prostaglandin J ( 2 ) , also induces COX-2 expression and inhibits *induced* [NFkappaB] activation and COX-2 expression . Positive_regulation NFKB1 TNF 10871845 708291 In the present report we show that anethole is a potent inhibitor of induced [NF-kappaB] *activation* ( an early response ) as monitored by electrophoretic mobility shift assay , IkappaBalpha phosphorylation and degradation , and NF-kappaB reporter gene expression . Positive_regulation NFKB1 TNF 10878378 708969 These results indicate that mitochondrial ROS are required for the hypoxic activation of NF-kappa B and gene transcription , but not for the LPS *activation* of [NF-kappa B] . Positive_regulation NFKB1 TNF 10881930 709231 IL-1beta and *induced* a rapid activation of [nuclear factor (NF)-kappaB] in PANC-1 cells , and the increase in chemokine mRNA expression correlated with NF-kappaB activation . Positive_regulation NFKB1 TNF 10882136 709451 A dominant negative mutant of IKKepsilon blocks induction of NF-kappaB by both PMA and activation of the T cell receptor but has no effect on the *activation* of [NF-KB] by or IL-1 . Positive_regulation NFKB1 TNF 10884313 709542 However , pretreatment with oATP downregulated *activation* of [NF-kappaB] and AP-1 by IL-1beta or . Positive_regulation NFKB1 TNF 10890505 710561 We have previously demonstrated that 1 micromol/L HQ inhibits *induced* activation of [NFkappaB] in CD4+ T cells , resulting in decreased IL-2 production . Positive_regulation NFKB1 TNF 10892347 711284 Gel-shift analysis of HUVEC demonstrated that pretreatment with pycnogenol exhibited a concentration dependent suppression of induced *activation* of [NF-kappa B] . Positive_regulation NFKB1 TNF 10893342 711467 We tested the hypothesis that the *stimulated* transcription factor [nuclear factor (NF)-kappaB] could , in part , mediate TNF-alpha action by inhibiting the transcriptional potency of the VDR and RXR at their cognate cis regulatory sites . Positive_regulation NFKB1 TNF 10903807 713241 The results indicate that , secreted by virus infected macrophages , *activates* [NF-kappa B] which impairs the IL-13 mediated inhibition of inducible NO synthase (iNOS) expression . Positive_regulation NFKB1 TNF 10903915 713438 We demonstrated here that intracellular localization of these redox molecules differ from each other and that the redox molecules differentially regulate [NF-kappaB] , AP-1 , and CREB activation *induced* by , PMA , and forskolin and by expression of signaling intermediate kinases , NIK , MEKK , and PKA in HEK293 cells . Positive_regulation NFKB1 TNF 10908694 715622 These genes are regulated by the transcription factor [NFkappaB] which in turn is *activated* by and cytokines . Positive_regulation NFKB1 TNF 10918504 716998 The expression of several cytokines and adhesion molecules is regulated by the transcription factor [NFkappaB] , which is *activated* by . Positive_regulation NFKB1 TNF 10919278 717220 Recently , it has been reported that tumor necrosis factor-alpha (TNF-alpha) activates the release of ceramide and that ceramide acts as a mediator for the *induced* stimulation of the binding affinity of [nuclear factor-KB (NF-KB)] , a ubiquitous transcription factor of particular importance in immune and inflammatory responses . Positive_regulation NFKB1 TNF 10919278 717222 In this study we demonstrate that dexamethasone , which reduces the production of ceramide , significantly inhibits *induced* activation of [NF-KB] , c-Jun N-terminal kinase , also known as stress activating protein kinase , caspase-3-like cysteine protease , redistribution of cytochrome c , and apoptosis in MC3T3E1 osteoblasts . Positive_regulation NFKB1 TNF 10919658 717260 Oleandrin blocked *induced* activation of [NF-kappaB] in a concentration- and time dependent manner . Positive_regulation NFKB1 TNF 10919658 717264 A proprietary hot water extract of oleander ( Anvirzel ) also blocked *induced* [NF-kappaB] activation ; Positive_regulation NFKB1 TNF 10919658 717266 The effects of oleandrin were not cell type specific , because it blocked *induced* [NF-kappaB] activation in a variety of cells . Positive_regulation NFKB1 TNF 10926553 718850 Challenge with H ( 2 ) O ( 2 ) also failed to induce NF-kappaB-driven reporter gene expression in the transduced HMEC-1 cells , whereas *increased* the [NF-kappaB-driven] gene expression approximately 10-fold . Positive_regulation NFKB1 TNF 10926553 718853 Gel supershift assay revealed the presence of p65 ( Rel A ) , p50 , and c-Rel in both H ( 2 ) O ( 2 ) - and *induced* [NF-kappaB] complexes bound to the ICAM-1 promoter , with the binding of the p65 subunit being the most prominent . Positive_regulation NFKB1 TNF 10930442 719831 Here we demonstrate that the *activation* of [NF-kappa B] by interferes with thyroid-hormone action as demonstrated by impairment of T ( 3 ) -dependent induction of 5'-DI gene expression in HepG2 cells . Positive_regulation NFKB1 TNF 10930442 719835 Furthermore , we show that an inhibitor of NF-kappa B activation , clarithromycin (CAM) , can inhibit *induced* activation of [NF-kappa B] and restore T ( 3 ) -dependent induction of 5'-DI mRNA and enzyme activity . Positive_regulation NFKB1 TNF 10930442 719839 These results suggest that [NF-kappa B] *activation* by is involved in the pathogenesis of euthyroid sick syndrome and that CAM could help prevent a decrease in serum T ( 3 ) levels and thus ameliorate euthyroid sick syndrome . Positive_regulation NFKB1 TNF 10938077 737431 , as well as certain other stimuli , also *induces* the phosphorylation of the [NF-kappaB] proteins . Positive_regulation NFKB1 TNF 10938077 737436 Previously , we have shown that induces RelA/p65 phosphorylation at serine 529 and that this inducible phosphorylation *increases* [NF-kappaB] transcriptional activity on an exogenously supplied reporter ( ) . Positive_regulation NFKB1 TNF 10940316 721032 [NFkappaB] activation in *response* to and bleomycin , the latter causing topoisomerase II-independent DNA damage , was intact in both cell lines . Positive_regulation NFKB1 TNF 10946303 722949 [NF-kappaB] DNA-protein binding and COX-2 promoter activity were *enhanced* by , and these effects were inhibited by genistein , U73122 , staurosporine , or pyrolidine dithiocarbamate . Positive_regulation NFKB1 TNF 10956637 724798 Gel shift and Western blot analyses confirmed that *activated* [NF-kappaB] and depleted IkappaB in this system and that these effects were prevented by MG-132 and pyrrolidine dithiocarbamate . Positive_regulation NFKB1 TNF 10963848 727471 We also demonstrate that histaglobin inhibits the nuclear translocation of [NF-kappaB] in *response* to or lipopolysaccharide (LPS) in bone marrow derived macrophages of Balb/c mice . Positive_regulation NFKB1 TNF 10970832 728839 To determine whether altered signal transduction through the nuclear factor (NF)-kappaB pathway occurs in CF epithelial cells and results in excessive generation of inflammatory cytokines , we evaluated induced production of the NF-kappaB dependent cytokine interleukin (IL)-8 and *activation* of [NF-kappaB] in three different human bronchial epithelial cell lines : ( 1 ) BEAS cells that express wild-type CF transmembrane conductance regulator ( CFTR ) , ( 2 ) IB3 cells with mutant CFTR , and ( 3 ) C38 cells , which are `` corrected '' IB3 cells complemented with wild-type CFTR . Positive_regulation NFKB1 TNF 10973919 729087 Expression of Rac1N17 blocked induced *activation* of [nuclear factor-kappa B (NF-kappaB)] , increased activity of caspase-3 , and markedly augmented endothelial cell susceptibility to TNF induced apoptosis . Positive_regulation NFKB1 TNF 10976991 729646 In the present study , we investigated effects of a synthetic glucocorticoid , dexamethasone ( Dex ) , on *dependent* activation of [NF-kappaB] and expression of the ICAM-1 gene . Positive_regulation NFKB1 TNF 10976991 729651 Electrophoretic mobility shift assay ( EMSA ) revealed that *dependent* activation of [NF-kappaB] was almost completely suppressed by Dex treatment . Positive_regulation NFKB1 TNF 10982546 732000 Adiponectin suppressed induced IkappaB-alpha phosphorylation and subsequent [NF-kappaB] *activation* without affecting other TNF-alpha mediated phosphorylation signals , including Jun N-terminal kinase , p38 kinase , and Akt kinase . Positive_regulation NFKB1 TNF 10984605 732220 The present study investigates the role of Akt in the *activation* of [NF-kappa B] by ( TNF alpha , 10 ng/ml ) and PDGF-BB ( 20 ng/ml ) in human vascular smooth muscle cells (SMC) , skin and foreskin fibroblasts . Positive_regulation NFKB1 TNF 10984605 732247 *stimulated* serine phosphorylation and degradation of the inhibitory protein I kappa B alpha and strongly induced nuclear [NF-kappa B] translocation and binding activity . Positive_regulation NFKB1 TNF 10993753 733451 Stimulation of myocytes with *resulted* in a 12.1-fold increase ( P < 0.01 ) in [NF-kappa B-dependent] gene transcription and DNA binding compared with controls . Positive_regulation NFKB1 TNF 10993753 733453 Adenovirus mediated delivery of a nonphosphorylatable form of I kappa B alpha to inactivate NF-kappa B prevented *stimulated* NF-kappa B-dependent gene transcription and nuclear [NF-kappa B] DNA binding . Positive_regulation NFKB1 TNF 11002422 734654 In this study , we demonstrate that the proteolytic cleavage of receptor interacting protein ( RIP ) by caspase-8 during TNF induced apoptosis abrogates the stimulatory role of RIP on *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 11002422 734656 Ectopic expression of the pro-apoptotic C-terminal fragment of RIP inhibited induced [NF-kappaB] *activation* by suppressing the activity of I-kappaB kinasebeta (IKKbeta) which phosphorylates I-kB , an inhibitor of NF-kappaB , and triggers its ubiquitin mediated degradation . Positive_regulation NFKB1 TNF 11003979 734875 We recently reported that rapidly *activates* [NF-kappaB] in differentiated skeletal muscle myotubes and that TNF-alpha acts directly on the muscle cell to induce protein degradation . Positive_regulation NFKB1 TNF 11006087 735181 Pyrrolidine dithiocarbamate inhibits *dependent* activation of [NF-kappaB] by increasing intracellular copper level in human aortic smooth muscle cells . Positive_regulation NFKB1 TNF 11006087 735185 In the present study , we investigated effects of PDTC and another antioxidant , N-acetyl-l-cysteine (NAC) , on *dependent* activation of [NF-kappaB] in human aortic smooth muscle cells ( HASMC ) . Positive_regulation NFKB1 TNF 11006087 735192 These results indicate that TNF-alpha dependent expression of MCP-1 in HASMC is tightly regulated by NF-kappaB and that intracellular copper level is crucial for the dependent *activation* of [NF-kappaB] in HASMC . Positive_regulation NFKB1 TNF 11007940 735630 The promoter regions of the human gamma-GCS subunits contain AP-1 , [NF-kappa B] , and antioxidant response elements and are *regulated* by oxidants , growth factors , inflammatory cytokine , and anti-inflammatory agent ( dexamethasone ) in lung cells . Positive_regulation NFKB1 TNF 11007940 735641 also *induces* the activation of [NF-kappa B] and AP-1 and the subsequent increase in gamma-GCS heavy subunit transcription in these cells . Positive_regulation NFKB1 TNF 11007945 735647 It has also been reported that [NF-kappa B] *activation* by , chemotherapeutic drugs , or ionizing radiations can protect several cell types against apoptosis , suggesting that NF-kappa B could participate in resistance to cancer treatment . Positive_regulation NFKB1 TNF 11009421 735886 Failure to regulate *induced* [NF-kappaB] and cell death responses in A20-deficient mice . Positive_regulation NFKB1 TNF 11009421 735888 A20 is a cytoplasmic zinc finger protein that inhibits [nuclear factor kappaB (NF-kappaB)] activity and *mediated* programmed cell death (PCD) . Positive_regulation NFKB1 TNF 11009421 735893 A20-deficient cells fail to terminate *induced* [NF-kappaB] responses . Positive_regulation NFKB1 TNF 11009421 735898 Thus , A20 is critical for limiting inflammation by terminating *induced* [NF-kappaB] responses in vivo . Positive_regulation NFKB1 TNF 11009425 735902 The transcription factor [nuclear factor kappa B (NF-kappaB)] is *activated* by the cytokine , a mediator of skeletal muscle wasting in cachexia . Positive_regulation NFKB1 TNF 11009425 735907 In differentiating C2C12 myocytes , *induced* activation of [NF-kappaB] inhibited SMD by suppressing MyoD mRNA at the posttranscriptional level . Positive_regulation NFKB1 TNF 11018074 737678 In wild-type mice , ethanol caused severe liver injury via a mechanism involving gut derived endotoxin , CD14 receptor , production of electron spin resonance-detectable free radicals , *activation* of the transcription factor [NF-kappaB] , and release of cytotoxic from activated Kupffer cells . Positive_regulation NFKB1 TNF 11023661 738333 Although both IL-1 and *activate* [NF-kappaB] in these cells , only IL-1 induces collagenase-1 transcription . Positive_regulation NFKB1 TNF 11029374 739836 The degree to which albumin increased GSH levels was sufficient to protect cells against H ( 2 ) O ( 2 ) -mediated cytotoxicity and to decrease mediated [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 11031204 740159 Electromobility gel shift and luciferase assays demonstrated that overexpression of IkappaBDeltaN inhibited [NF-kappaB] activation *induced* by or interleukin-1beta (IL-1beta) . Positive_regulation NFKB1 TNF 11045567 742605 Primary embryonic fibroblasts derived from mice with a null mutation in Peg3 showed no abnormalities in *induced* nuclear translocation of [nuclear factor kappaB (NF-kappaB)] or phosphorylation of the mitogen activated protein kinases , extracellular signal regulated kinases 1 and 2 , c-Jun N-terminal kinase/stress activated protein kinase ( JNK/SAPK ) , and p38 . Positive_regulation NFKB1 TNF 11046018 742741 Because the nuclear transcription factors NF-kappaB and AP-1 have recently been reported to mediate anti-apoptosis and cell survival , we hypothesized that IFN-alpha potentiates the cytotoxic effects of TNF by suppressing induced *activation* of [NF-kappaB] and AP-1 . Positive_regulation NFKB1 TNF 11046018 742744 We tested this hypothesis by pretreating human Jurkat T cells with IFN-alpha , which blocked induced *activation* of [NF-kappaB] and AP-1 in a time- and dose dependent manner as determined by EMSA . Positive_regulation NFKB1 TNF 11067942 747603 These results indicate that sustained [NF-kappaB] activation in asthmatic bronchi is driven by granulocytes and is *mediated* by IL-1beta and . Positive_regulation NFKB1 TNF 11067959 747607 Previously , we have demonstrated that leflunomide inhibits *induced* [NF-kappaB] activation by suppressing I-kappaBalpha ( inhibitory subunit of NF-kappaB ) degradation . Positive_regulation NFKB1 TNF 11068016 747627 Furthermore , *increased* [NF-kappaB] DNA binding , which was abolished by pretreatment with pyrrolidine dithiocarbamate . Positive_regulation NFKB1 TNF 11083876 810017 Inhibition of TLR2 had no effect on alpha *induced* [NF-kappaB] or AP-1 activation , on the DNA binding of the basal transcription factor Oct-1 , or on hydrogen peroxide induced phosphorylation of p38 MAP kinase . Positive_regulation NFKB1 TNF 11087727 786358 *induces* distinctive [NF-kappa B] signaling within human dermal fibroblasts . Positive_regulation NFKB1 TNF 11087727 786360 Further , [NF-kappa B] *activation* by was unaffected by overexpression of a dominant negative mutant NIK in fibroblasts , despite detection of endogenous TRAF2 and NIK by Western analysis . Positive_regulation NFKB1 TNF 11093734 755022 Tumor necrosis factor alpha (TNF-alpha) binding to the initiates apoptosis and simultaneously *activates* the transcription factor , [nuclear factor-kappaB (NF-kappaB)] , which suppresses apoptosis by an unknown mechanism . Positive_regulation NFKB1 TNF 11096064 802158 To test the hypothesis that fluid flow alters NF-kappaB activation and expression of cell adhesion molecules in osteoblastic cells , we examined the effect of oscillating fluid flow ( OFF ) on *induced* [NF-kappaB] activation in rat osteoblast-like UMR106 cells . Positive_regulation NFKB1 TNF 11096064 802161 We found that OFF inhibits NF-kappaB-DNA binding activities , especially *induced* p50-p65 heterodimer [NF-kappaB] activation and TNF-alpha induced intercellular adhesion molecule-1 mRNA expression . Positive_regulation NFKB1 TNF 11096064 802164 The inhibitory effects of OFF on both induced [NF-kappaB] *activation* and intercellular adhesion molecule-1 mRNA expression were shear stress dependent and also increased with OFF exposure duration , indicating that OFF has potent effects on mechanotransduction pathways . Positive_regulation NFKB1 TNF 11096064 802172 Thus , OFF inhibits TNF-alpha induced IKK activation , leading to a decrease in phosphorylation and degradation of inhibitory IkappaBalpha , which in turn results in the decrease of induced [NF-kappaB] *activation* and potentially the transcription of target genes . Positive_regulation NFKB1 TNF 11104733 756512 Stimulation of HASM cells with *increased* [NF-kappaB] DNA binding activity . Positive_regulation NFKB1 TNF 11104733 756516 However , increased [ cAMP ] ( i ) in HASM neither activated NF-kappaB nor altered *induced* [NF-kappaB] DNA binding activity . Positive_regulation NFKB1 TNF 11108246 756744 However , *induced* [NF-kappaB] DNA binding activity is independent of p38MAPK and ERK activation . Positive_regulation NFKB1 TNF 11112416 757589 *Activation* of [NF-kappa B] by mediates many functions of TNF-alpha . Positive_regulation NFKB1 TNF 11112416 757595 In MCF-7 cells ( an estrogen and TNF-alpha receptor positive cell line ) , treatment with 17 beta-estradiol ( E ( 2 ) ) inhibited *induced* [NF-kappa B] DNA binding activity in the gel retardation assays . Positive_regulation NFKB1 TNF 11112449 757635 *dependent* activation of [NF-kappa B] in human osteoblastic HOS-TE85 cells is repressed in vector averaged gravity using clinostat rotation . Positive_regulation NFKB1 TNF 11112449 757639 Effects of vector averaged gravity on *dependent* activation of [nuclear factor kappa B (NF-kappa B)] in human osteoblastic HOS-TE85 cells were investigated by culturing the cells using clinostat rotation ( clinorotation ) . Positive_regulation NFKB1 TNF 11112449 757643 Electrophoretic mobility shift assays revealed that dependent *activation* of [NF-kappa B] was markedly reduced in the clinorotated cells when compared with the cells in control stationary cultures or after horizontal rotation ( motional controls ) . Positive_regulation NFKB1 TNF 11112449 757647 Consistent with these findings , the dependent *induction* of endogenous [NF-kappa B-responsive] genes p105 , I kappa B-alpha , and IL-8 , was significantly attenuate in clinorotated cells . Positive_regulation NFKB1 TNF 11115778 757917 Electrophoretic mobility shift assays ( EMSAs ) revealed that IL-1 beta and *activate* the transcription factor [NF kappa B] in reaggregates of rat anterior pituitaries and in TtT/Gf cells cultured alone or cocultured with GH3 cells . Positive_regulation NFKB1 TNF 11116146 786592 [NF-kappaB] *activation* by the involves the formation of a multiprotein complex termed a signalosome . Positive_regulation NFKB1 TNF 11118442 786654 can also *promote* [nuclear factor kappaB (NF-kappaB)] activity and regulate the expression of genes that interfere with apoptosis and thus conferring resistance to several apoptotic stimuli . Positive_regulation NFKB1 TNF 11118442 786657 These findings show that NO might interfere with *dependent* [NF-kappaB] activation by interacting with O ( 2 ) and reducing the generation of H ( 2 ) O ( 2 ) , a potent NF-kappaB activator . Positive_regulation NFKB1 TNF 11120942 768505 We examined whether or not clarithromycin inhibits the activation of [NF-kappaB] *induced* by or staphylococcal enterotoxin A (SEA) in human monocytic U-937 cells , a T-cell line ( Jurkat ) , a pulmonary epithelial cell line ( A549 ) , and peripheral blood mononuclear cells ( PBMC ) . Positive_regulation NFKB1 TNF 11120942 768508 Flow cytometry revealed that clarithromycin suppresses [NF-kappaB] activation *induced* by in U-937 and Jurkat cells in a concentration related manner . Positive_regulation NFKB1 TNF 11120942 768510 Western blot analysis also demonstrated that clarithromycin inhibits [NF-kappaB] activation *induced* by in U-937 , Jurkat , and A549 cells and PBMC and by SEA in PBMC . Positive_regulation NFKB1 TNF 11133232 769108 Importantly , expression of I kappa B ( S32A , S36A ) results in complete abrogation of myocardial [NF-kappa B] activation in *response* to and LPS stimulation . Positive_regulation NFKB1 TNF 11133489 769143 ASA inhibited *induced* activation of [NF-kappa B] by preventing phosphorylation and subsequent degradation of I kappa B-alpha in a prostanoid independent manner . Positive_regulation NFKB1 TNF 11160233 781553 Of interest , mediated *activation* of the cellular transcription factor [NF-kappaB] was unaffected by PTX-B . Positive_regulation NFKB1 TNF 11162606 782274 BIM did not inhibit [NF-kappa B] *activation* by but caused activation of caspases and enhanced cleavage of PKC delta and -epsilon . Positive_regulation NFKB1 TNF 11162639 782340 Homocysteine attenuated TNF-alpha stimulated U-937 adhesion to the endothelial monolayer and reduced *induced* activation of the transcription factor [NF-kappaB] , indicating that NF-kappaB inhibition may play a role in inhibiting expression of adhesion molecules in endothelial cells . Positive_regulation NFKB1 TNF 11165942 782864 However , the specific inhibitor of p38 MAPK , SB203580 , had no effect on induced [NF-kappaB] *activation* and both NF-kappaB inhibitors failed to reduce the p38 MAPK activation in the TNF-alpha stimulated osteoblasts . Positive_regulation NFKB1 TNF 11191283 761389 *activated* [NF-kappaB] in gel shift experiments without inducing iNOS -- as assessed by nitrite formation -- whereas IL-1beta stimulated both NF-kappaB activation and iNOS induction . Positive_regulation NFKB1 TNF 11191283 761398 However , both ceramide and potentiated IL-1beta- *induced* activation of [NF-kappaB] and iNOS . Positive_regulation NFKB1 TNF 11198351 779640 We addressed the role of the redox state of endothelial cells in modulating *induced* [NF-kappaB] activity . Positive_regulation NFKB1 TNF 11198351 779650 Stimulation of control cells with *resulted* in reactive oxygen species ( ROS ) generation and activation of [NF-kappaB] binding to the ICAM-1 promoter and ICAM-1 transcription . Positive_regulation NFKB1 TNF 11200499 762159 The designed compound , DHM2EQ , inhibited *induced* activation of [NF-kappaB] and showed a therapeutic effect in mouse rheumatoid arthritis model . Positive_regulation NFKB1 TNF 11212226 785778 Follow-up analyses demonstrated that , although *activated* [NF-kappaB] through IkappaB-alpha degradation , alpha-Fas treatment led to NF-kappaB activation through a mechanism distinct from IkappaB-alpha degradation . Positive_regulation NFKB1 TNF 11223427 787888 *stimulated* the translocation of [nuclear factor-kappaB (NF-kappaB)] , an effect that was not modified by cerivastatin . Positive_regulation NFKB1 TNF 11225736 580993 In the present study , we analyzed the signaling pathway by which *activates* [NF-kappaB] in myotubes differentiated from C2C12 and rat primary myoblasts . Positive_regulation NFKB1 TNF 11225736 580997 We found that *activation* of [NF-kappaB] by was blocked by rotenone or amytal , inhibitors of complex I of the mitochondrial respiratory chain . Positive_regulation NFKB1 TNF 11228746 580999 induced [NF-kappa B] *activation* was inhibited by both superoxide and lipid peroxide quenchers but potentiated by an hydroxyl radical quencher . Positive_regulation NFKB1 TNF 11228746 581016 Overall , these results suggest that hydroxyl radicals mediate induced apoptosis but not *activation* of [NF-kappa B] , AP-1 , and JNK ; Positive_regulation NFKB1 TNF 11235987 764120 Moreover , antioxidants inhibited *induced* osteosarcoma cell invasion , motility and [NFkappaB] nuclear translocation , but not adhesion to laminin or MMP9 expression . Positive_regulation NFKB1 TNF 11237861 790424 In the present study we investigated how TSH is involved in the *activation* of [NF-kappaB] by in the cells . Positive_regulation NFKB1 TNF 11238809 791141 Effects of SAC on hydrogen peroxide ( H ( 2 ) O ( 2 ) ) or *induced* [nuclear factor (NF)-kappa B] activation were determined . Positive_regulation NFKB1 TNF 11238809 791143 SAC also inhibited H ( 2 ) O ( 2 ) - or *induced* [NF-kappa B] activation . Positive_regulation NFKB1 TNF 11243852 792249 Transient transfection study of NF-kappaB promoter construct and electrophoretic mobility shift assay suggested that hematein inhibited both NF-kappaB dependent gene expression and [NF-kappaB] activation *induced* by . Positive_regulation NFKB1 TNF 11257457 794471 The luciferase assay demonstrated that overexpression of EXTL3 enhanced *induced* [NF-kappaB] activity . Positive_regulation NFKB1 TNF 11257457 794477 These results suggest that EXTL3 may modulate [NF-kappaB] *mediated* by . Positive_regulation NFKB1 TNF 11262181 796265 Here , we addressed the question of whether small GTPases of the Rho family are involved in the *stimulation* of [NF-kappaB] signaling by genotoxic agents or in HeLa cells . Positive_regulation NFKB1 TNF 11262181 796272 Specific blockage of Rho signaling by Clostridium difficile toxin B attenuated UV- and doxorubicin induced activation of NF-kappaB , but did not affect *stimulation* of [NF-kappaB] by . Positive_regulation NFKB1 TNF 11266388 796751 and Jo2 *induced* iNOS messenger RNA and protein levels through the induction of [NF-kappaB] . Positive_regulation NFKB1 TNF 11266466 796902 Overexpression of a Y42F mutant of IkappaBalpha potently suppressed NFG- , but not *induced* [NFkappaB] activation . Positive_regulation NFKB1 TNF 11266466 796906 We conclude that NGF and *induce* different signaling pathways in neurons to activate [NFkappaB] and bcl-x gene expression . Positive_regulation NFKB1 TNF 11279196 819636 Overexpression of the icp75TNFR cDNA results in induced *activation* of [NFkappaB] in a TNF receptor associated factor 2 (TRAF2) dependent manner . Positive_regulation NFKB1 TNF 11280761 798764 VEGF effectively blocked *induced* [NF-kappaB] activation in HPCs from RelB-/- mice , however , similar to the effect observed in HPCs obtained from RelB+/- and RelB+/+ mice . Positive_regulation NFKB1 TNF 11280761 798772 Thus , VEGF appears to inhibit *induced* [NF-kappaB] activation by VEGFR kinase independent inhibition of IKK . Positive_regulation NFKB1 TNF 11289659 800571 S-nitrosoglutathione inhibits *induced* [NFkappaB] activation in neutrophils . Positive_regulation NFKB1 TNF 11289659 800573 *increased* nuclear [NFkappaB] activity compared to unstimulated neutrophils ( p < 0.001 , n = 5 ) . Positive_regulation NFKB1 TNF 11289659 800577 GSNO ( 500 microM ) decreased *induced* [NFkappaB] activity ( p < 0.05 ) and inhibited NFkappaB activity whether given prior to or during TNFalpha exposure . Positive_regulation NFKB1 TNF 11306890 804340 [NF-kB] signaling *induced* by is suppressed by IFNalpha and IFNgamma in the permanent cell lines and in the primary RCC tumor cell cultures . Positive_regulation NFKB1 TNF 11309390 820011 Activation of [NF-kappaB] in *response* to and glutamate was completely abolished when IP ( 3 ) receptors were blocked , and NF-kappaB activation in response to depletion of ER calcium by thapsigargin treatment was also decreased by IP ( 3 ) receptor blockade . Positive_regulation NFKB1 TNF 11313989 806213 Moreover , induction of p53 interfered with *induced* [NF-kappaB] activation independently from apoptosis-induction . Positive_regulation NFKB1 TNF 11316563 806483 [NF-kappaB] is *activated* by , certain chemotherapeutic agents , and ionizing radiation , leading to inhibition of apoptosis . Positive_regulation NFKB1 TNF 11318879 806748 Although the *induction* of [NF-kappaB] by dsRNA/virus and involves common downstream pathways including IKK activation , the upstream , Geldanamycin-sensitive process was unique to the dsRNA/virus induced signal . Positive_regulation NFKB1 TNF 11322949 807239 ( iv ) IFNalpha treatment attenuated *induced* [NF-kappaB] reporter activity , while it did not inhibit DNA binding of NF-kappaB . Positive_regulation NFKB1 TNF 11322949 807241 Taken collectively , our results indicate that IFNalpha sensitizes ME-180 cells to TNFalpha induced apoptosis by inhibiting *mediated* cytoprotective [NF-kappaB] activation , and this sensitizing effect of IFNalpha is mediated through a STAT1 dependent pathway . Positive_regulation NFKB1 TNF 11336164 809293 and IL-1 *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 11336543 812035 However , [NF kappa B] *activation* by was not significantly altered by the HCV core protein , suggesting the existence of TRAF2 independent pathways for NF kappa B activation . Positive_regulation NFKB1 TNF 11337375 812180 *induced* maximal translocation of [NF-kappaB] into the nucleus of non-CF as well as CF airway cells within 20 minutes . Positive_regulation NFKB1 TNF 11337489 827567 We have demonstrated that overexpression of the EGF receptor (EGFR) in NIH3T3 cells significantly enhances *induced* [NF-kappa B-dependent] luciferase activity even without EGF , that EGF treatment has a synergistic effect on the induction of the reporter activity , and that this enhancement is suppressed by AG1478 , EGFR-specific tyrosine kinase inhibitor . Positive_regulation NFKB1 TNF 11337489 827578 Taken together , this evidence strongly suggests that EGFR transactivation by , which is regulated in a redox dependent manner , is playing a pivotal *role* in TNF induced [NF-kappa B] activation . Positive_regulation NFKB1 TNF 11340079 827660 Here we show that antisense oligonucleotide induced inhibition of FLASH expression abolished *induced* activation of [NF-kappaB] in HEK293 cells , as determined by luciferase reporter gene expression driven by a NF-kappaB responsive promoter . Positive_regulation NFKB1 TNF 11340302 812460 Increased binding activity of [NFkappaB] *induced* by was effectively blocked by the NFkappaB decoy ODN . Positive_regulation NFKB1 TNF 11342564 827722 induced *activation* of [NF-kappa B-dependent] gene expression is not modulated by LiCl treatment . Positive_regulation NFKB1 TNF 11344085 814128 *activated* [nuclear factor-kappaB (NF-kappaB)] and interfered with the expression of muscle proteins in differentiating myoblasts . Positive_regulation NFKB1 TNF 11350953 834341 Our results indicate that overexpression of cRel or *activation* of endogenous [Rel/NF-kappaB] factors by in HeLa cells up-regulates DcR1 without changing the expression of DcR2 , DR4 , and DR5 and makes cells resistant against TRAIL induced apoptosis . Positive_regulation NFKB1 TNF 11356844 834427 Activation of phosphatidylinositol (PI) 3-kinase/Akt signaling by *activates* IKK and [NF-kappaB] . Positive_regulation NFKB1 TNF 11356844 834466 activated Akt in PC-3 cells , but not in DU145 cells , and the ability of TNF to activate [NF-kappaB] was *blocked* by pharmacological inhibition of PI 3-kinase activity in PC-3 cells , but not in DU145 cells . Positive_regulation NFKB1 TNF 11359904 816571 Treatment of SV80 cells with the proteasome inhibitor N-benzoyloxycarbonyl ( Z ) -Leu-Leu-leucinal ( MG-132 ) or geldanamycin , a drug interfering with *induced* [NF-kappaB] activation , inhibited TNF induced upregulation of cFLIP . Positive_regulation NFKB1 TNF 11368927 817344 Soy isoflavone supplementation in healthy men prevents [NF-kappa B] *activation* by in blood lymphocytes . Positive_regulation NFKB1 TNF 11368927 817346 In this study , we have demonstrated that genistein , but not daidzein , inhibits induced [NF-kappa B] *activation* in cultured human lymphocytes . Positive_regulation NFKB1 TNF 11368927 817348 Additionally , we investigated the in vivo effect of soy isoflavone supplementation on [NF-kappa B] activation *induced* by in vitro in peripheral blood lymphocytes of six healthy men . Positive_regulation NFKB1 TNF 11374864 817885 Hepatitis C virus core protein potentiates induced [NF-kappaB] *activation* through TRAF2-IKKbeta dependent pathway . Positive_regulation NFKB1 TNF 11374864 817887 Previous work has implicated that the core protein of hepatitis C virus ( HCV ) may play a modulatory effect on [NF-kappaB] activation *induced* by . Positive_regulation NFKB1 TNF 11374864 817889 Here we show that overexpression of HCV core protein potentiates [NF-kappaB] activation *induced* by . Positive_regulation NFKB1 TNF 11374864 817897 In addition , HCV core protein associates with TNF-R1-TRADD-TRAF2 signaling complex , resulting in synergistically activation of [NF-kappaB] *induced* by . Positive_regulation NFKB1 TNF 11382928 820943 *induces* [NFkappaB/p50] in association with the growth and morphogenesis of normal and transformed rat mammary epithelial cells . Positive_regulation NFKB1 TNF 11382928 820949 There were no changes in the levels of p65 or c-rel . induced a pronounced and sustained *increase* of a p50 homodimeric [NFkappaB/DNA] complex in both normal and transformed MEC . Positive_regulation NFKB1 TNF 11389905 822430 Here , we show that a minimum of four zinc fingers is required to inhibit *induced* [nuclear factor-kappaB (NF-kappaB)] activation to a level that is comparable to that obtained with the wild-type A20 protein . Positive_regulation NFKB1 TNF 11389905 822432 Moreover , we demonstrate that complete loss of binding of any of these proteins correlates with complete loss of A20 's ability to inhibit *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 11390371 842546 and interleukin (IL)-1beta are potent *activators* of the transcription factor [NF-kappaB] , induced during inflammatory conditions . Positive_regulation NFKB1 TNF 11390377 842577 [NF-kappaB] activation *induced* by and interleukin-1 is inhibited by overexpression of ABIN-2 . Positive_regulation NFKB1 TNF 11391531 822931 Induction of Mdr1b expression by in rat liver cells is independent of p53 but *requires* [NF-kappaB] signaling . Positive_regulation NFKB1 TNF 11399512 824219 Since *induced* [NF-kappa B] activation , cell cycle arrest , RB dephosphorylation , and E2F downregulation are indistinguishable in both cell lines , none of these factors is likely to be involved in the TNF induced anti-apoptotic mechanism in A375-6 cells . Positive_regulation NFKB1 TNF 11410870 826496 In line with this , not only the *induced* activation of caspases and apoptosis but also that of [NF-kappaB] was enhanced by 1,25 ( OH ) ( 2 ) D ( 3 ) pre-treatment . Positive_regulation NFKB1 TNF 11410870 826498 Furthermore , 1,25 ( OH ) ( 2 ) D ( 3 ) enhanced *induced* [NF-kappaB] activation in T47D cells suggesting that it potentiates TNF signaling in general . Positive_regulation NFKB1 TNF 11415944 829174 Treatment with H2O2 also inhibited *induced* IkappaBalpha breakdown , [NF-kappaB] DNA binding activity , and NF-kappaB dependent transcription but had no effect on TNF-alpha induced IkappaBalpha phosphorylation or ubiquitination . Positive_regulation NFKB1 TNF 11418646 830258 Although Akt has been reported to activate NF-kappaB , DMS and LY 294002 failed to prevent *induced* [NF-kappaB] activation , suggesting that the antiapoptotic effects of SphK and Akt are independent of NF-kappaB . Positive_regulation NFKB1 TNF 11420300 830584 Deletion of the redox-sensitive domain of Ref-1 significantly inhibited induced [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 11420300 830586 Moreover , it seems that Ref-1 may act as a critical cofactor , mediating the *induced* [NF-kappaB] response in the vascular endothelium . Positive_regulation NFKB1 TNF 11423913 831035 Neither U0126 nor LY294002 pretreatment affected *induced* activation of [NF-kappaB] , suggesting that the MAP kinase or PI3-kinase/Akt mediated anti-apoptotic effect induced by TNF was not relevant to NF-kappaB activation . Positive_regulation NFKB1 TNF 11428868 831566 Furthermore , co-administration of U0126 and SB202190 did not affect the induced degradation of IkappaB-alpha and NF-kappaB nuclear translocation , indicating that [NF-kappaB] is *activated* by IL-1beta and independently of activation of MEK/MAPK and p38 pathways in hRPE cells . Positive_regulation NFKB1 TNF 11429546 831650 The essential role of MEKK3 in induced [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 11429546 831662 Using mitogen activated protein kinase kinase kinase 3 ( MEKK3 ) -deficient fibroblast cells , we found that MEKK3 plays a critical role in *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 11429546 831669 The kinase activity of MEKK3 is pivotal to its function and , therefore , MEKK3 links RIP and IKK in *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 11431731 831880 Lastly , activation of the Akt/protein kinase B (PKB) , which has recently been implicated in [NF-kappaB] *activation* by PDGF , , and Ras , was also observed . Positive_regulation NFKB1 TNF 11437539 832849 Furthermore , overexpression *activated* [NF- kappa B] , a mediator of anti-apoptotic pathways , in the myocardium . Positive_regulation NFKB1 TNF 11438547 843383 In this report , by using macrophages derived from wild-type mice ( having both receptors ) and mice in which the gene for either p60 ( p60 ( -/- ) ) , or p80 ( p80 ( -/- ) ) , or both ( p60 ( -/- ) p80 ( -/- ) ) receptor have been deleted , we have redefined the role of these receptors in *induced* activation of [nuclear factor (NF)-kappa B] and of mitogen activated protein kinases . Positive_regulation NFKB1 TNF 11438547 843385 *activated* [NF-kappa B] in a dose- and time dependent manner in wild-type macrophages but not in p60 ( -/- ) , p80 ( -/- ) , or p60 ( -/- ) p80 ( -/- ) macrophages . Positive_regulation NFKB1 TNF 11444925 834162 Addition of proteasome inhibitor MG132 or adenoviral expression of a truncated I kappa B alpha ( I kappa B Delta N ) inhibited *induced* [NF-kappa B] nuclear translocation in a dose dependent manner . Positive_regulation NFKB1 TNF 11445585 860033 We have shown previously that secretory nonpancreatic ( snp ) and cytosolic ( c ) phospholipase A(2) ( PLA(2) ) regulate [NF-kappaB] activation in *response* to or interleukin (IL)-1beta activation and that a functional coupling mediated by the 5-lipoxygenase (5-LO) metabolite leukotriene B ( 4 ) ( LTB ( 4 ) ) exists between snpPLA ( 2 ) and cPLA(2) in human keratinocytes . Positive_regulation NFKB1 TNF 11445585 860045 In this study , we have further investigated the mechanisms of PLA(2) modulated NF-kappaB activation with respect to specific kinases involved in *stimulated* cPLA(2) phosphorylation and [NF-kappaB] activation . Positive_regulation NFKB1 TNF 11445585 860051 The protein kinase C ( PKC ) inhibitors RO 31-8220 , Gö 6976 , and a pseudosubstrate peptide inhibitor of atypical PKCs attenuated arachidonic acid release , cPLA(2) phosphorylation , and [NF-kappaB] activation *induced* by or IL-1beta , thus indicating atypical PKCs in cPLA(2) regulation and transcription factor activation . Positive_regulation NFKB1 TNF 11445585 860069 Hence , lambda/iotaPKC regulates snpPLA ( 2 ) /LTB ( 4 ) -mediated cPLA(2) activation , cellular arachidonic acid release , and [NF-kappaB] activation *induced* by and IL-1beta . Positive_regulation NFKB1 TNF 11450703 836640 Thus , we investigated whether *activates* a transcription factor [nuclear factor kappaB (NF-kappaB)] in human chondrocyte-like cells ( HCS-2/8 ) and induces the expression of genes involved in the degradation of cartilage matrix . Positive_regulation NFKB1 TNF 11450703 836651 Thus , it is shown that the *activation* of p65/p50 [NF-kappaB] by plays a cardinal role in inducing the expression of MMP-1 , MMP-3 , ICAM-1 , and COX-2 genes , which are involved in matrix degradation and inflammatory reaction in chondrocytes , leading to chondrocytic chondrolysis . Positive_regulation NFKB1 TNF 11461927 850946 Modulation of apoptosis *inducing* ligand- induced [NF-kappa B] activation by inhibition of apical caspases . Positive_regulation NFKB1 TNF 11461927 850952 Receptor interacting protein , an obligatory component of *induced* [NF-kappaB] activation , was cleaved during TRAIL induced apoptosis . Positive_regulation NFKB1 TNF 11470788 860371 IKKgamma/NEMO is an essential regulatory component of the IkappaB kinase complex that is required for [NF-kappaB] activation in *response* to various stimuli including and interleukin-1beta . Positive_regulation NFKB1 TNF 11472980 841552 Geldanamycin inhibited mediated [NF-kappaB] *activation* as measured by electromobility shift assays and transient transfections with a NF-kappaB dependent luciferase reporter plasmid . Positive_regulation NFKB1 TNF 11474119 766077 The effect of H2O2 on *induced* activation of [nuclear factor kappa B (NF-kappaB)] was measured by Western blots of cytoplasmic and nuclear extracts of RBEC using anti-inhibitor of NF-kappaB ( IkappaB ) and anti-p65 subunit of NF-kappaB antibodies . Positive_regulation NFKB1 TNF 11479302 860570 Critical roles of TRAF2 and TRAF5 in *induced* [NF-kappa B] activation and protection from cell death . Positive_regulation NFKB1 TNF 11479302 860585 However , the exact roles of TRAF2 and TRAF5 in *induced* [NF-kappaB] activation still remain controversial . Positive_regulation NFKB1 TNF 11479302 860595 Collectively , these results indicate that both TRAF2 and TRAF5 are involved in *induced* [NF-kappaB] activation and protection from cell death . Positive_regulation NFKB1 TNF 11483407 844318 [NF-kappaB] DNA-protein binding and ICAM-1 promoter activity were *enhanced* by and these effects were inhibited by D 609 , calphostin C , or tyrphostin 23 , but not by PD 98059 or SB 203580 . Positive_regulation NFKB1 TNF 11489936 845477 Late Erk1/2 activation was involved in *stimulated* [NF-kappa B] activation and cytokine induction . Positive_regulation NFKB1 TNF 11489969 845542 Both and phorbol ester 12,0-tetradecanoylphorbol 13-acetate ( TPA ) *enhanced* [NF-kappaB] activity but only TPA increased HCMV replication . Positive_regulation NFKB1 TNF 11494147 846181 In this study we demonstrate that *triggers* only modest proliferation , as well as p44/p42 mitogen activated protein kinase (MAPK) and [NF-kappaB] activation , in MM.1S multiple myeloma ( MM ) cells . Positive_regulation NFKB1 TNF 11494147 846184 also *activates* [NF-kappaB] and markedly upregulates ( fivefold ) secretion of interleukin-6 (IL-6) , a myeloma growth and survival factor , in bone marrow stromal cells ( BMSCs ) . Positive_regulation NFKB1 TNF 11494147 846192 Importantly , the proteasome inhibitor PS-341 abrogated induced [NF-kappaB] *activation* , induction of ICAM-1 or VCAM-1 , and increased adhesion of MM cells to BMSCs . Positive_regulation NFKB1 TNF 11500927 847141 SME or Sal B significantly inhibited *induced* activation of [nuclear factor kappa B (NF-kappaB)] in HAECs ( 0.36- and 0.48-fold , respectively ) . Positive_regulation NFKB1 TNF 11500933 847144 However , expression of neither p38beta nor its dominant negative mutant in mesangial cells interfered with *induced* translocation of [NF-kappaB] , the initial step of NF-kappaB activation . Positive_regulation NFKB1 TNF 11500933 847146 While it is unclear whether p38beta regulates NF-kappaB transcription activity at other steps , it is apparent that p38beta does not affect *induced* [NF-kappaB] activation at the stage of nuclear translocation . Positive_regulation NFKB1 TNF 11505050 847902 In HepG2 cells , both IFNalpha and acute alcohol treatment induced NF-kappaB activation and augmented *induced* [NF-kappaB] binding . Positive_regulation NFKB1 TNF 11505050 847904 Pretreatment of HepG2 cells with IFNalpha resulted in the highest levels of [NF-kappaB] activation in *response* to or TNFalpha plus ethanol stimulation . Positive_regulation NFKB1 TNF 11505407 847916 TNFalpha induced inhibition of the EpCAM expression is mediated by TNF receptor 1 through the receptor associated death domain protein ( TRADD ) and by the *activation* of [nuclear factor kappaB (NF-kappaB)] , and it can be blocked by dominant negative variants of TRADD and the NF-kappaB inhibitor , IkappaB . Positive_regulation NFKB1 TNF 11506747 848006 These cells were found to constitutively express high levels of active [NF-kappaB] that can not be further *activated* by . Positive_regulation NFKB1 TNF 11509005 848228 also *induced* [nuclear factor-kappaB (NF-kappaB)] translocation to the nucleus , an essential step in GM-CSF mRNA production . Positive_regulation NFKB1 TNF 11509327 848294 Using primary passage-1 human tracheobronchial epithelial cell cultures and an immortalized human bronchial epithelial cell line , HBE1 , we observed that *enhanced* [NF-kappa B] transcriptional activity . Positive_regulation NFKB1 TNF 11509327 848296 Pretreatment with N-acetyl-cysteine (NAC) ( 1 to 10 mM ) or glutathione ( 1 to 10 mM ) inhibited induced *activation* of [NF-kappa B] transcriptional activity and IL-8 promoter mediated reporter gene expression . Positive_regulation NFKB1 TNF 11509327 848300 In contrast , elevated TRX protein levels in cells enhanced *dependent* [NF-kappa B] transcriptional activity and IL-8 promoter activity . Positive_regulation NFKB1 TNF 11509639 848633 We investigated the effects of MTX on [NF-kappaB] activation *induced* by in Jurkat cells . Positive_regulation NFKB1 TNF 11509639 848637 The treatment of these cells with MTX suppressed *induced* [NF-kappaB] activation with optimum effects occurring at 10 microM MTX for 60 min . Positive_regulation NFKB1 TNF 11509639 848641 The suppression of *induced* [NF-kappaB] activation by MTX correlated with inhibition of IkappaBalpha degradation , suppression of IkappaBalpha phosphorylation , abrogation of IkappaBalpha kinase activation , and inhibition of NF-kappaB dependent reporter gene expression . Positive_regulation NFKB1 TNF 11522182 852738 Tumor necrosis factor receptor (TNFR) p55 was the prominent receptor , as neutralizing antibodies to TNFR p55 , but not to TNFR p75 , blocked mediated [NF-kappa B] *activation* . Positive_regulation NFKB1 TNF 11546645 856535 Similarly , *activated* [NF-kappa B] through TK , p42/44 , p38 MAPKs , and PARP pathways in SVEC cells . Positive_regulation NFKB1 TNF 11556546 861077 Inhibitory action of nitric oxide on circulating *induced* [NF-kappaB] activity and COX-2 transcription in the endothelium of the brain capillaries . Positive_regulation NFKB1 TNF 11556546 861080 This study investigated the hypothesis that nitric oxide ( NO ) acts as an endogenous modulator of *induced* [NF-kappaB] signaling and COX-2 transcription in the endothelium of the cerebral capillaries . Positive_regulation NFKB1 TNF 11556546 861083 These results indicate that eNOS derived NO acts as an endogenous inhibitor of *induced* [NF-kappaB] activity and COX-2 transcription in the endothelium of the cerebral capillaries . Positive_regulation NFKB1 TNF 11557763 875286 As both and PMA rapidly *induce* [NF-kappaB] activation this suggests that NEMO/IKKgamma dependent activation of the NF-kappaB pathway is necessary but not sufficient for up-regulation of TRAIL in T cells . Positive_regulation NFKB1 TNF 11561906 862730 TGF-beta as well as *induced* activation of [NFKB] and upregulated bcl-xL . Positive_regulation NFKB1 TNF 11562425 862790 SB203580 and PD98059 had little effect on induced [nuclear factor-kappa B (NF-kappa B)] *activation* as determined in cells transfected with a NF-kappa B-luciferase reporter construct . Positive_regulation NFKB1 TNF 11572859 882354 Using confocal microscopy and cell fractionation studies , butyrate pretreatment of a human colon cell line ( HT-29 cells ) inhibited the *induced* nuclear translocation of the proinflammatory transcription factor [NF-kappaB] . Positive_regulation NFKB1 TNF 11572998 864827 Both F094 and avicin G were found to be potent inhibitors of *induced* [NF-kappaB] . Positive_regulation NFKB1 TNF 11575451 865000 Extracellular stimuli , notably interleukin-1beta (IL-1beta) and *activate* [NF-kappaB] nuclear translocation via IkappaB phosphorylation and degradation . Positive_regulation NFKB1 TNF 11583588 865688 However , an IRAK-1 variant lacking only the N-terminal domain retained the ability of the full-length protein to potentiate both IL-1 beta and *induced* [NF-kappa B] activation . Positive_regulation NFKB1 TNF 11592111 869677 Lipopolysaccharide (LPS) treatment of a microglial cell line ( N9 ) *induced* a time dependent activation of both p38 mitogen activated protein kinase ( p38 MAPK ) and [nuclear factor-kappaB (NFkappaB)] , with consequent increases in interleukin-1alpha (IL-1alpha) , , and nitric oxide ( NO ) production . Positive_regulation NFKB1 TNF 11594795 870093 A20 , a TNF inducible gene , inhibits *mediated* apoptosis as well as [NF-kappa B] induced by this cytokine . Positive_regulation NFKB1 TNF 11600498 903807 These results suggest that low but persistent IKK activity and I kappa B degradation lead to prolonged [NF-kappa B] nuclear translocation and maximal AT(1) up-regulation in the continued *presence* of . Positive_regulation NFKB1 TNF 11675371 873167 CpG DNA and LPS synergistically *induce* production in RAW264.7 cells and J774 cells through activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 11676476 873424 BRE , a putative stress modulating gene , found able to down-regulate *induced* [NF-kappaB] activation upon overexpression , is now shown in human cells expressed as multiple mRNA isoforms . Positive_regulation NFKB1 TNF 11682062 873991 Here we studied the effect of cPrG . HCl on *induced* activation of the transcription factor [nuclear factor kappaB (NF-kappaB)] . Positive_regulation NFKB1 TNF 11682062 874008 cPrG . HCl inhibited neither the *induced* phosphorylation and degradation of inhibitor of nuclear factor-kappaB , nor the subsequent nuclear translocation and DNA binding of [NF-kappaB] . Positive_regulation NFKB1 TNF 11689467 876275 Alpha-lipoic acid inhibits *induced* [NF-kappaB] activation and adhesion molecule expression in human aortic endothelial cells . Positive_regulation NFKB1 TNF 11689467 876281 Furthermore , LA dose-dependently inhibited *induced* IkappaB kinase activation , subsequent degradation of IkappaB , the cytoplasmic NF-kappaB inhibitor , and nuclear translocation of [NF-kappaB] . Positive_regulation NFKB1 TNF 11689467 876283 In contrast , *induced* [NF-kappaB] activation and adhesion molecule expression were not affected by ascorbic acid or by manipulating cellular glutathione status with l-2-oxo-4-thiazolidinecarboxylic acid , N-acetyl-l-cysteine , or d , l-buthionine-S , R-sulfoximine . Positive_regulation NFKB1 TNF 11698503 878186 In naive cells , LPS , , and IL-1beta *induced* IkappaBalpha degradation , kinase phosphorylation , and [NF-kappaB] DNA binding . Positive_regulation NFKB1 TNF 11704541 879295 Increased expression of MMP-9 and [NF-kappa B] activation *induced* by were inhibited by pyrrolidine dithiocarbamate and N-acetyl-L-cysteine but were not inhibited by curcumin . Positive_regulation NFKB1 TNF 11712859 880313 Both troglitazone and 15d-PGJ ( 2 ) markedly inhibited *induced* [NF-kappaB] activation at 30 microM . Positive_regulation NFKB1 TNF 11715495 581292 To investigate whether could *activate* the signaling [pathway-NF-kappa B/I-kappa] B alpha required for the expression of inducible nitric oxide synthase (iNOS) to induce endothelial cell apoptosis by nitric oxide ( NO ) . Positive_regulation NFKB1 TNF 11717189 881907 IL-4 enhanced *induced* activation of the transcription factor [NF-kappaB] . Positive_regulation NFKB1 TNF 11729200 904354 In this study , we explored a novel function of polymorphonuclear neutrophils ( PMN ) NAD(P)H oxidase in the mechanism of *induced* [NF-kappaB] activation and intercellular adhesion molecule-1 ( ICAM-1 ) expression in endothelial cells . Positive_regulation NFKB1 TNF 11729200 904357 Induction of neutropenia using anti-PMN serum prevented the initial induced [NF-kappaB] *activation* and ICAM-1 expression in WT mice , indicating the involvement of PMN NAD(P)H oxidase in signaling these responses . Positive_regulation NFKB1 TNF 11729200 904360 Thus , oxidant signaling by the PMN NAD(P)H oxidase complex is an important determinant of induced [NF-kappaB] *activation* and ICAM-1 expression in endothelial cells . Positive_regulation NFKB1 TNF 11730360 884945 We found that both IL-1beta and could independently *activate* cytosolic [NF-kappaB] , direct its translocation into the nucleus , and induce iNOS monomer synthesis . Positive_regulation NFKB1 TNF 11734559 914839 This interaction is a prerequisite for RIP3 mediated phosphorylation of RIP and subsequent attenuation of induced [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 11742346 897759 We find that the Siah1a SBD potentiates mediated [NF-kappa B] *activation* . Positive_regulation NFKB1 TNF 11753638 890162 *induced* [NF-kappaB] activation but not AP-1 activation in LNCaP cells . Positive_regulation NFKB1 TNF 11753679 890178 *induces* the expression of DR6 , a member of the TNF receptor family , through activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 11755130 890231 In circulating blood neutrophils , *induced* activation of [nuclear factor-kappa B (NF-kappa B)] , whereas , in tissue neutrophils , NF-kappa B had been already activated without any stimulation , and no further activation was induced by the treatment with TNF-alpha . Positive_regulation NFKB1 TNF 11755929 898990 Both IL-1beta and *stimulated* [NF-kappaB] activity , iNOS mRNA and protein expression with massive nitrite/nitrate ( NOx ) production in rat VSMCs . Positive_regulation NFKB1 TNF 11773980 890553 A549 human lung carcinoma cells were infected with adenoviral constructs carrying dominant negative mutants of Rac1 and IKK or constitutively active mutant of Rac1 , upstream effectors in mediated [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 11775855 581317 LPS might activate [NF-kappa B] in the PIMs , and *induce* the increase of transcription and expression of gene ; Positive_regulation NFKB1 TNF 11777983 899877 EMSAs demonstrated that IL-17 , IL-1beta , and *induced* [NF-kappaB] activation within 1.5 h after stimulation , and a blockade of NF-kappaB activation by the pyrrolidine derivative of dithiocarbamate and tosyl-phe-chloromethylketone markedly reduced the IL-17- , IL-1beta- , or TNF-alpha induced IL-6 gene expression . Positive_regulation NFKB1 TNF 11796489 902211 In contrast , cell stimulation with the cytokine *allowed* activation of [NFkappaB] through phosphorylation , ubiquitination , and subsequent degradation of IkappaBalpha . Positive_regulation NFKB1 TNF 11799112 922228 PTEN blocks *induced* [NF-kappa B-dependent] transcription by inhibiting the transactivation potential of the p65 subunit . Positive_regulation NFKB1 TNF 11799112 922236 In this report , we utilized PTEN as a natural biological inhibitor of Akt activity to study the effects on *induced* activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 11799112 922238 We found that the reintroduction of PTEN into prostate cells inhibited *stimulated* [NF-kappaB] transcriptional activity . Positive_regulation NFKB1 TNF 11799112 922274 PTEN failed to block induced IKK *activation* , IkappaBalpha degradation , p105 processing , p65 ( RelA ) nuclear translocation , and DNA binding of [NF-kappaB] . Positive_regulation NFKB1 TNF 11804328 892577 Overexpression of LRR-1 suppressed the activation of [NF-KB] *induced* by 4-1BB or 2 . Positive_regulation NFKB1 TNF 11811521 892762 [NF-kappaB] was *activated* by in all four cell types tested . Positive_regulation NFKB1 TNF 11813164 907430 Consequently , *triggers* [NF-kappaB] mobilization from the cytoplasm to the nucleus , as determined by tracking the NF-kappaB subunit p65 by immunofluorescence and Western blot analysis . Positive_regulation NFKB1 TNF 11813164 907432 Inhibition of mediated IkappaBalpha degradation and [NF-kappaB] *activation* by gliotoxin or the proteasome inhibitor MG-132 un-masks the caspase dependent pro-apoptotic properties of TNF-alpha . Positive_regulation NFKB1 TNF 11821383 928884 CARD-8 was also found to negatively regulate [NF-kappaB] *activation* by stimulation and by ectopically expressed RICK , suggesting that this protein may control cell survival . Positive_regulation NFKB1 TNF 11821416 922607 Here we show that overexpression of NS5A inhibits *induced* [nuclear factor kappaB (NF-kappaB)] activation in HEK293 cells , as determined by luciferase reporter gene expression and by electrophoretic mobility shift assay . Positive_regulation NFKB1 TNF 11821416 922613 Our findings suggest a possible molecular mechanism that could explain the ability of NS5A to negatively regulate *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 11823712 909330 *activates* a transcription factor [NF-kappaB] that binds promoters of multiple genes , thus ensuring pleiotropic effects of TNF-alpha . Positive_regulation NFKB1 TNF 11827262 909396 Here , we report that an adenovirus mediated gene transfer of NF-kappaB inhibitor , super-repressor I kappa B alpha ( Adv-SR-IkappaBalpha ) , blocked *induced* [NF-kappaB] activation and sensitized oral SCC cells to TNF killing . Positive_regulation NFKB1 TNF 11831701 291258 The stimulatory effect of is *mediated* by induction of the transcription factor [NF-kappaB] , which specifically binds to the 18-bp repetitive sequence motif of the enhancer region . Positive_regulation NFKB1 TNF 11835405 911411 Whether signal transducer and activator of transcription-1 ( STAT1 ) , which mediates interferon ( IFN ) signaling , also plays any role in the mediated *activation* of [NF-kappaB] , JNK , and apoptosis has not been established . Positive_regulation NFKB1 TNF 11835405 911431 *activated* [NF-kappaB] , consisting of p50 and p65 , in both U3A and U3A-pSG91 cells in a dose- and time dependent manner , but the degree and rate of activation were slightly lower in U3A cells , as were IkappaBalpha degradation and NF-kappaB dependent reporter gene expression . Positive_regulation NFKB1 TNF 11835405 911435 STAT1 was , however , required for IFNalpha mediated downregulation of *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 11837795 911524 Following heat shock , decreased *induced* [NF-kappaB] activation was observed and was associated with preservation of IkappaB-alpha and a decrease in phosphorylated IkappaB-alpha that correlated to inhibition of I kappa kinase (IKK) activity . Positive_regulation NFKB1 TNF 11839649 911658 Recently , sulindac and other nonsteroidal anti-inflammatory drugs have been shown to inhibit mediated [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 11839649 911660 We further show that sulindac inhibits *mediated* activation of [NF-kappaB] DNA binding and nuclear translocation of NF-kappaB . Positive_regulation NFKB1 TNF 11841920 912263 HM from an animal model of ALD have increased nonheme iron content accompanied by increased generation of EPR detected radicals , [NF-kappaB] activation , and *induction* , all of which are normalized by ex vivo treatment of the cells with deferiprone . Positive_regulation NFKB1 TNF 11843050 912380 inhibition *reduced* the [NF-kappaB] activation , and blocked a transient wave of epithelial cell proliferation 12 h after the injection . Positive_regulation NFKB1 TNF 11847111 912588 It has been proposed that mediated *activation* of [NFkappaB] leads to down regulation of MyoD , however the mechanisms underlying TNFalpha effects on skeletal muscle remain poorly understood . Positive_regulation NFKB1 TNF 11851362 913232 Electrophoretic mobility shift assay demonstrated that *induced* [nuclear factor- kappa B (NF-kappa B)-specific] DNA binding . Positive_regulation NFKB1 TNF 11851362 913236 The I kappa B alpha mutant suppressed [NF-kappa B] activation *induced* by . Positive_regulation NFKB1 TNF 11851362 913238 NAC abolished induced [NF-kappa B] *activation* and hypertrophic responses . Positive_regulation NFKB1 TNF 11855810 914051 There was no difference , however , in the ability of heat shock to inhibit mediated [NF-kappaB] *activation* , IkappaBalpha degradation , IkappaB kinase activation , and macrophage chemotactic protein-1 expression in the HSF-1-/- cells compared to the HSF-1+/+ cells . Positive_regulation NFKB1 TNF 11864612 917626 Geldanamycin ( GA ) , an antitumor agent that disrupts the formation of this heterocomplex , prevents induced *activation* of IKK and [NF-kappaB] . Positive_regulation NFKB1 TNF 11864954 917684 Potential of rifamides to inhibit *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 11877450 937179 Also , treatment of cells with kamebakaurin prevented the *induced* expression of antiapoptotic [NF-kappaB] target genes encoding c-IAP1 ( hiap-2 ) and c-IAP2 ( hiap-1 ) , members of the inhibitor of apoptosis family , and Bfl-1/A1 , a prosurvival Bcl-2 homologue , and augmented the TNF-alpha induced caspase 8 activity , thereby resulting in sensitizing MCF-7 cells to TNF-alpha induced apoptosis . Positive_regulation NFKB1 TNF 11886496 894183 Using CD62E , NF-kappa B , or AP-1-responsive promoter constructs , dimethylfumarate inhibited *induced* activation of the CD62E and the [NF-kappa B] but not the AP-1 promoter construct . Positive_regulation NFKB1 TNF 11896607 920949 Silibinin inhibits constitutive and *induced* activation of [NF-kappaB] and sensitizes human prostate carcinoma DU145 cells to TNFalpha induced apoptosis . Positive_regulation NFKB1 TNF 11896607 920953 In such a scenario , strong apoptotic agent , further *induces* [NF-kappaB] activation rather than inducing apoptosis . Positive_regulation NFKB1 TNF 11896607 920955 Additional studies showed that silibinin also inhibits induced *activation* of [NF-kappaB] via IkappaBalpha pathway and subsequently sensitizes DU145 cells to TNFalpha induced apoptosis . Positive_regulation NFKB1 TNF 11909725 923758 The compounds display good potency in inhibiting *induced* apoptosis and [NF kappa B] activation . Positive_regulation NFKB1 TNF 11918294 925605 mediates polymethylmethacrylate particle *induced* [NF-kappaB] activation in osteoclast precursor cells . Positive_regulation NFKB1 TNF 11922866 984269 DNA binding studies using NF-kappaB subunit specific binding ELISA demonstrated that RSV and *induced* different [NF-kappaB] binding complexes containing Rel A ( p65 ) and NF-kappaB1 ( p50 ) . Positive_regulation NFKB1 TNF 11928721 927215 Electrophoretic mobility shift assay showed that proteasome inhibitors diminished *stimulated* [nuclear factor-kappa B (NF-kappaB)] activation in ECs . Positive_regulation NFKB1 TNF 11934806 927869 Concomitantly , ExPLIs inhibited the LPS induced activation of [NF-kappaB] by LPS but not its *activation* by or IL-1 . Positive_regulation NFKB1 TNF 11943206 928677 *activates* pro-inflammatory transcription factor [nuclear factor-kappaB (NF-kappaB)] by uncertain signalling mechanisms . Positive_regulation NFKB1 TNF 11943805 928750 Moreover , little [nuclear factor-kappaB (NF-kappaB)] translocation is *induced* by in neurons of TNFRI -/- , whereas NF-kappaB subunit p65 is still translocated from the cytoplasm into the nucleus in neurons from wild-type and TNFRII -/- mice . Positive_regulation NFKB1 TNF 11948689 930236 DeltaIkappaBalpha suppressed the transactivation of [NF-kappaB] *induced* by or TRAIL , as reflected by luciferase-reporter activity . Positive_regulation NFKB1 TNF 11950023 930283 *induced* [NF-kappaB] nuclear translocation and DNA binding in all OA synovial tissue explants , although there were no consistent effects on AP-1 DNA binding . Positive_regulation NFKB1 TNF 11950023 930285 Dexamethasone partially inhibits *induced* [NF-kappaB] DNA binding in human synovial tissue . Positive_regulation NFKB1 TNF 11954826 930695 Hyperoxia prolongs mediated *activation* of [NF-kappaB] : role of IkappaB kinase . Positive_regulation NFKB1 TNF 11954826 930697 Stimulation with alone *increased* [NF-kappaB] activation within 1 h and induced IkappaB alpha degradation within 0.5 h . Positive_regulation NFKB1 TNF 11954826 930704 These data demonstrate that while hyperoxia alone does not affect activation of NF-kappaB , hyperoxia prolongs *mediated* activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 11956090 930965 Whereas AV1Y28 inhibited NF-kappaB activation by hydrogen peroxide and ferricyanide , it had no effect of *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 11956601 931211 Furthermore , NDPP1 is able to inhibit [NF-kappaB] activation *induced* by treatment in HepG2 cells . Positive_regulation NFKB1 TNF 11960552 984297 *activated* [NF-kappaB] , along with IkappaBalpha degradation , occurred at 20 to 60 min in Hyal-2 cells post stimulation , but at the 20 min time point in both control and Hyal-1 cells . Positive_regulation NFKB1 TNF 11961404 932608 SIN-1 inhibited the *induced* [NF-kappaB] binding activity . Positive_regulation NFKB1 TNF 11967955 938055 Moreover , CCM was able to inhibit both the constitutional and *induced* [NF-kappaB] activation in a time dependent manner . Positive_regulation NFKB1 TNF 11976329 954025 Stimulation of cells with *triggers* [NF-kappaB1] p105 proteolysis , releasing associated Rel subunits to translocate into the nucleus and modulate target gene expression . Positive_regulation NFKB1 TNF 11983688 954129 It also inhibited the *induced* DNA binding of nuclear [NF-kappaB] but not the phosphorylation and degradation of IkappaB . Positive_regulation NFKB1 TNF 11986318 961668 Indirect immunofluorescence shows that E7 impairs *induced* nuclear translocation of NF-kappaB , thus preventing [NF-kappaB] from binding to its cognate DNA . Positive_regulation NFKB1 TNF 11991856 938592 These acute-alcohol induced changes in monocytic cells were different compared to T lymphocytes , both in Jurkat CD4 cells and peripheral human T cells , acute alcohol had a biphasic effect on *induced* [NF-kappa B] activation via an I-kappa B alpha dependent mechanism . Positive_regulation NFKB1 TNF 11991979 938620 We demonstrate here that the E3 region of Ad inhibits the activation of [NF-kappa B] *induced* by and interleukin-1 . Positive_regulation NFKB1 TNF 12003776 939876 Enalapril protects mice from pulmonary hypertension by inhibiting mediated *activation* of [NF-kappaB] and AP-1 . Positive_regulation NFKB1 TNF 12007574 940593 In contrast to , which *activates* [NF-kappaB] in minutes , NF-kappaB activation induced by anticancer drugs usually occurred more than 1hr after stimulation . Positive_regulation NFKB1 TNF 12010810 941312 In this study , alone *induced* [NF-kappaB] nuclear translocation , cIAP-1 and cIAP-2 up-regulation , and MM cell proliferation ; Positive_regulation NFKB1 TNF 12010810 941315 Moreover , SN50 inhibited *induced* expression of another [NF-kappaB] target gene , intercellular adhesion molecule-1 . Positive_regulation NFKB1 TNF 12021482 943212 Western blot analysis revealed that TNF-alpha caused degradation of I kappa B alpha within 10 min. EMSA demonstrated that *led* to increased DNA binding activity of [NF kappa B] and that proteasome inhibitors counteracted NF kappa B activation . Positive_regulation NFKB1 TNF 12023051 943495 Electrophoretic mobility shift assay revealed that H2O2 enhanced induced [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 12023343 943732 However , [NF-kappaB] activation *induced* by could be sustained by blocking autocrine IL-10 . Positive_regulation NFKB1 TNF 12023359 943741 Induction of macrophage-inflammatory protein-3alpha gene expression by *dependent* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 12032830 948135 Therefore , MnSOD expression is induced by [NF-kappaB] in epithelial cancer cells in *response* to , and is at least partially responsible for their resistance to TNF-alpha induced apoptosis , presumably through the clearance of death inducing ROS . Positive_regulation NFKB1 TNF 12052823 968765 On the other hand mediated [NF-kappa B] *activation* is not reduced by the phosphoinositide-3 kinase inhibitors wortmannin and LY294002 , although these inhibitors completely block the activation of Akt . Positive_regulation NFKB1 TNF 12055072 951606 Inhibition of either PKC-delta or PI 3-kinase attenuated *mediated* activation of the antiapoptotic transcription factor [NFkappaB] . Positive_regulation NFKB1 TNF 12055104 951692 Interleukin (IL)-1beta- and *induced* [NF-kappaB] activation and kappaB dependent gene expression are inhibited in HeLa cells but not in Ad5dnNIK infected HT-29 cells . Positive_regulation NFKB1 TNF 12060665 975673 Ectopic expression of protein-tyrosine kinase Bcr-Abl suppresses induced [NF-kappa B] *activation* and IkappaBalpha phosphorylation . Positive_regulation NFKB1 TNF 12060665 975676 We used a bcr-abl-deficient human megakaryocytic leukemia cell line MO7E and an isogenic MBA cell line stably transfected with bcr-abl. Electrophoretic mobility shift assay revealed that *activated* the nuclear transcription factor [NF-kappaB] in MO7E cells but not in MBA cells . Positive_regulation NFKB1 TNF 12060665 975693 The suppression of TNF induced NF-kappaB activation by Bcr-Abl was not restricted to MBA cells , because ectopic expression of Bcr-Abl in human acute myeloid leukemia HL-60 cells also blocked induced [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 12060857 952846 Furthermore , somatostatin suppressed *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 12065308 954339 Role of glycogen synthase kinase-3 in *induced* [NF-kappaB] activation and apoptosis in hepatocytes . Positive_regulation NFKB1 TNF 12065308 954341 In this study , we determined the role of GSK-3 in *induced* [NF-kappaB] activation and cell death in primary hepatocytes . Positive_regulation NFKB1 TNF 12065326 954376 Because Gab1 is involved in both c-Jun and [NF-kappaB] *activation* by , we focused on Gab1 dependent signaling . Positive_regulation NFKB1 TNF 12065326 954394 Gab1 associated with MEKK3 , and a catalytically inactive form of MEKK3 inhibited *induced* c-Jun and [NF-kappaB] transcriptional activation , suggesting a critical role for Gab1 and MEKK3 in TNF-alpha signaling . Positive_regulation NFKB1 TNF 12065710 954669 Silymarin also inhibited *induced* [NF-kappaB/Rel] activation , whereas okadaic acid induced NF-kappaB/Rel activation was not affected . Positive_regulation NFKB1 TNF 12065913 954836 We examined whether or not theophylline inhibits *induced* activation of the nuclear transcription factor [NF-kappaB] , a factor that is essential for the expression of proinflammatory cytokines , in human monocytic U-937 cells , a T cell line ( Jurkat ) and peripheral blood mononuclear cells ( PBMC ) . Positive_regulation NFKB1 TNF 12065913 954838 The inhibitory effect of theophylline on *induced* [NF-kappaB] activation was evaluated by Western blotting , flow cytometry and chloramphenicol acetyltransferase (CAT) assaying . Positive_regulation NFKB1 TNF 12067303 954961 Using EMSA , both MG-132 and NaSal were found to suppress the *induced* [NF-kappaB] activation in eosinophils . Positive_regulation NFKB1 TNF 12080044 976095 The zinc finger protein A20 is a target gene of [NF kappa B] *inducible* by , and it is a potent inhibitor of TNF induced apoptosis . Positive_regulation NFKB1 TNF 12091251 960079 RAW 264.7 macrophages exhibited enhanced TNF-alpha production and NF-kappaB activation in response to silica , whereas IC-21 macrophages did not produce in response to silica and did not *induce* [NF-kappaB] nuclear binding . Positive_regulation NFKB1 TNF 12115190 964092 In addition , cepharanthine suppressed the *stimulated* [NF-kappaB] activity by partly preventing the degradation of IkappaBalpha protein in NS-SV-AC cells . Positive_regulation NFKB1 TNF 12119420 968905 E1A expression did not block upstream events in induced *activation* of [NF-kappa B] in NIH 3T3 cells , including degradation of I kappa B-alpha , nuclear translocation of NF-kappa B subunits , and their dimeric binding to kappa B sequences in the nucleus . Positive_regulation NFKB1 TNF 12131776 966844 IL-1 beta and *increased* the [nuclear factor-kappa B (NF-kappa B)-specific] and activator protein-1-specific DNA binding activity , whereas the NF-IL6 activity was not altered . Positive_regulation NFKB1 TNF 12135603 967387 ANP reduced *induced* [NF-kappaB] activity , which was paralleled by a decreased translocation of p65 to nuclei . Positive_regulation NFKB1 TNF 12135878 967620 *induced* IkappaB phosphorylation and [NFkappaB] activation . Positive_regulation NFKB1 TNF 12137562 997526 Co-transfection with [NF-kappaB] expression vectors or *stimulation* with resulted in significant transactivation of the jfc1 promoter construct , although transactivation of a mutated jfc1 promoter was negligible . Positive_regulation NFKB1 TNF 12138205 969183 This mutated form of Cot also acts as a dominant negative for T-cell antigen receptor/CD28- or Akt/phorbol myristate acetate induced NF-kappa B induction , while having relatively little effect on *induction* of [NF-kappa B] . Positive_regulation NFKB1 TNF 12143039 969599 *dependent* activation of [NF-kappa B] induces the transcription of antiapoptotic genes that renders liver cells resistant against TNF induced apoptosis . Positive_regulation NFKB1 TNF 12154098 997642 In addition , GW4869 did not significantly impair *induced* [NF-kappaB] translocation to nuclei . Positive_regulation NFKB1 TNF 12161520 971960 Electrophoretic mobility shift assay revealed that ( 1 ng/ml ) and phorbol 12-myristate 13-acetate ( TPA ; 0.4 micro M ) , PKC activator , *caused* marked increases in nuclear [NF-kappa B] DNA binding activity . Positive_regulation NFKB1 TNF 12162440 971990 Oxidative stress and *induce* histone acetylation and [NF-kappaB/AP-1] activation in alveolar epithelial cells : potential mechanism in gene transcription in lung inflammation . Positive_regulation NFKB1 TNF 12162440 972000 H2O2 , and , and TSA all *increased* [NF-kappaB] and AP-1 DNA binding to their consensus sites assessed by the electrophoretic mobility shift assay . Positive_regulation NFKB1 TNF 12165487 972840 EMSAs demonstrated that IL-17 did not modulate the *induced* [NF-kappaB] DNA binding activity , but markedly decreased TNF-alpha induced IFN regulatory factor-1 (IRF-1) DNA binding activity . Positive_regulation NFKB1 TNF 12168567 973644 or endotoxin *induce* the activation of two major transcription factors , [NF-kappa B] ( nuclear factor-kappaB ) and AP-1 ( activating protein-1 ) , which in turn induce genes involved in chronic and acute inflammatory responses . Positive_regulation NFKB1 TNF 12176728 975476 NAC decreased *induced* activation of [NF-kappaB] only marginally , indicating that the redox-sensitive component of the inhibition of myogenic differentiation by TNF-alpha occurred independently , or downstream of NF-kappaB . Positive_regulation NFKB1 TNF 12181188 977500 In conclusion , Fe2+ serves as a direct agonist to activate IKK , [NF-kappaB] , and TNF-alpha promoter activity and to *induce* the release of protein by cultured Kupffer cells in a redox status dependent manner . Positive_regulation NFKB1 TNF 12181323 992624 Because the CTAR2 region interacts with the tumor necrosis factor ( TNF-alpha receptor associated death domain protein , it is interesting to find that BRAM1 also interferes with [NF-kappaB] activation *mediated* by . Positive_regulation NFKB1 TNF 12181323 992626 BRAM1 interferes LMP1 mediated and *induced* [NF-kappaB] activation by targeting IkappaBalpha molecules . Positive_regulation NFKB1 TNF 12192035 980754 Here we report that even though NF-kappaB interacts directly with TAF(II)s , *induction* of [NF-kappaB] by does not enhance TFIID recruitment and preinitiation complex formation on some NF-kappaB-responsive promoters . Positive_regulation NFKB1 TNF 12192055 980840 Correspondingly , IKK and [NF-kappaB] *activation* by and , to a lesser extent , IL-1 are reduced . Positive_regulation NFKB1 TNF 12193057 980902 In addition , FK409 diminished basal and *stimulated* [NF-kappa B] activation in ECs . Positive_regulation NFKB1 TNF 12193701 981436 We conclude that SOCS-1 inhibits cytokine induced CD40 expression by blocking IFN-gamma mediated STAT-1alpha activation , which also then results in suppression of IFN-gamma induced secretion and subsequent [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 12196549 997904 induced activation of the Fas-ligand promoter in IEC *requires* [NF-kappaB] as this was blocked by an I-kappaBalphaM super-repressor and by mutation of an NF-kappaB site in the Fas-ligand promoter . Positive_regulation NFKB1 TNF 12207915 983643 In addition , merlin blocked the *induced* [NF-kappaB-DNA] binding mediated via the inhibition of degradation of IkappaBalpha and blocked the activation of NF-kappaB dependent transcription . Positive_regulation NFKB1 TNF 12208496 983787 Exogenous neutral ( N ) and acidic ( A ) SMase activated NF-kappa B with different kinetics , accounting for the diverse pattern of DNA binding of [NF-kappa B] complexes *activated* by . Positive_regulation NFKB1 TNF 12213594 985542 In order to analyze the role of Rho proteins in *induced* [NF-kappaB-activation] in human umbilical cord vein endothelial cells ( HUVEC ) we used Clostridium difficile toxin B-10463 ( TcdB-10463 ) which inactivates RhoA/Rac1/Cdc42 by glucosylation and Clostridium botulinum C3-toxin which inhibits RhoA/B/C by ADP-ribosylation . Positive_regulation NFKB1 TNF 12213594 985548 Neither 1 microM Rho kinase inhibitor Y-27632 nor microfilament depolymerization by 50 ng/mL C. botulinum C2-toxin blocked *induced* degradation of Ikappa-B , nuclear [NF-kappaB] translocation or expression of a NF-kappaB dependent reporter gene . Positive_regulation NFKB1 TNF 12219013 986610 The 2 groups of mice were analyzed for serum levels of interferon-gamma , , and interleukin-1beta as well as *activation* of [NFkappaB] and STAT1 , 2 proinflammatory transcription factors . Positive_regulation NFKB1 TNF 12225945 987883 Inhibition of JNK signaling also substantially reduced induced [NF-kappaB] *transactivation* , whereas inhibition of ERK and p38 had no effect . Positive_regulation NFKB1 TNF 12244103 1012532 NEMO interacts with a COOH-terminal sequence within both IKKs termed the NEMO binding domain (NBD) , and a cell-permeable NBD peptide blocks NEMO/IKKbeta interactions and inhibits *induced* [NF-kappaB] . Positive_regulation NFKB1 TNF 12244143 990504 family receptors can *lead* to the activation of [NF-kappaB] and this can be a prosurvival signal in some cells . Positive_regulation NFKB1 TNF 12354747 993636 Both LPS and *induced* significant [NFkappaB] activation , cyclooxygenase-2 (COX-2) expression , and inducible NO synthase (iNOS) and cytokine production ; Positive_regulation NFKB1 TNF 12356823 994051 Decreased dissociation could in turn suppress *induced* activation of [NFkappaB] , resulting in declines in expression of IL-1alpha gene and protein . Positive_regulation NFKB1 TNF 12361763 995020 alone can *induce* MCMV IE-1 gene expression and activation of [NFkappaB] and AP-1 in some tissues . Positive_regulation NFKB1 TNF 12361763 995024 We propose that induction of IE-1 gene expression is the first step in reactivation of the virus in an immunocompromised transplant recipient , and that it occurs as a result of the allogeneic response , which induces expression of and subsequent *activation* of [NFkappaB] , and ischemia/reperfusion injury , which induces activation of AP-1 . Positive_regulation NFKB1 TNF 12368351 995404 Here , we demonstrate that TSA ( NaBut ) synergized with both ectopically expressed p50/p65 and *induced* [NF-kappaB] to activate the LTR . Positive_regulation NFKB1 TNF 12372676 996461 Ox-LDL and *increased* the activation of [NF-kappaB] and the preincubation of HUVECs with zofenoprilat , but not with enalaprilat , dose dependently reduced its activation ( P < .001 ) . Positive_regulation NFKB1 TNF 12379212 997090 PLL-g-HA/NF-kappaB31 , but not control oligodeoxynucleotides having a reverse or scrambled sequence , inhibited the intranuclear localization of [NF-kappaB] *induced* by , with almost complete inhibition at 2 .5microg/mL as DNA . Positive_regulation NFKB1 TNF 12380642 997331 Alteration of cytokine release was accompanied by reduced basal and *stimulated* [nuclear factor-kappa B (NF-kappa B)] and activator protein-1 (AP-1) activity . Positive_regulation NFKB1 TNF 12388747 1000285 In contrast to [nuclear factor-kappaB (NF-kappaB)] *activation* by , the specific processes involved in the activation of this transcription factor by ionizing radiation ( IR ) have not been completely defined . Positive_regulation NFKB1 TNF 12390026 1000400 Vitamin C suppresses *induced* [NF kappa B] activation by inhibiting I kappa B alpha phosphorylation . Positive_regulation NFKB1 TNF 12390026 1000408 We found that intracellular vitamin C inhibits *induced* activation of [NFkappaB] in human cell lines ( HeLa , monocytic U937 , myeloid leukemia HL-60 , and breast MCF7 ) and primary endothelial cells ( HUVEC ) in a dose dependent manner . Positive_regulation NFKB1 TNF 12390026 1000410 Vitamin C-loaded cells showed significantly decreased *induced* nuclear translocation of [NFkappaB] , NFkappaB dependent reporter transcription , and IkappaBalpha phosphorylation . Positive_regulation NFKB1 TNF 12395315 1008631 Although con A-induced liver injury depends on both TNFR1 and TNFR2 , dependent iNOS expression is mediated exclusively by TNFR1 and *requires* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 12404274 1009774 The results showed that can *induce* activation of [NF-kappaB] and that the activation and translocation of NF-kappaB into the nucleus is responsible for promoting the 3-D cytomorphologic differentiation of anaplastic thyroid carcinoma cells , which was inhibited by the NF-kappaB translocation inhibitor , NF-kappaB SN50 . Positive_regulation NFKB1 TNF 12404274 1009779 The current data suggest that can *induce* thyrocyte differentiation in anaplastic thyroid carcinoma cells through [NF-kappaB] and that it merits investigation as differentiation therapy for the treatment of patients with anaplastic thyroid carcinoma . Positive_regulation NFKB1 TNF 12411493 1010843 Siah2 efficiently decreases *dependent* induction of JNK activity and transcriptional activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 12431991 1037094 We propose that the biphasic activation of [NF-kappaB] in *response* to may play a key regulatory role in skeletal muscle wasting associated with cachexia . Positive_regulation NFKB1 TNF 12436048 1016122 Our results indicate that acute alcohol inhibits IL-1beta- and *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 12442886 1017120 The designed compound , dehydroxymethyl-epoxyquinomicin ( DHMEQ ) , inhibited the *induced* activation of [NF-kappaB] , and showed an anti-arthritic effect in mice . Positive_regulation NFKB1 TNF 12442886 1017122 DHMEQ inhibited the *induced* cellular DNA binding of nuclear [NF-kappaB] , but not the phosphorylation or degradation of I-kappaB . Positive_regulation NFKB1 TNF 12444159 1017396 Piceatannol inhibits *induced* [NF-kappaB] activation and NF-kappaB mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation . Positive_regulation NFKB1 TNF 12444159 1017398 The treatment of human myeloid cells with piceatannol suppressed *induced* DNA binding activity of [NF-kappaB] . Positive_regulation NFKB1 TNF 12444159 1017400 The effect of piceatannol was not restricted to myeloid cells , as *induced* [NF-kappaB] activation was also suppressed in lymphocyte and epithelial cells . Positive_regulation NFKB1 TNF 12471036 1055492 We found basal binding of p300 , p50/p65 [NF-kappaB] , cyclic AMP regulatory element binding protein-2 , CCAAT/enhancer binding protein beta , and c-Jun. p50/p65 and p300 binding was selectively *increased* by . Positive_regulation NFKB1 TNF 12480916 1024252 Of interest , *induced* persistent [nuclear factor-kappaB (NF-kappaB)-DNA] binding activity even in the presence of SNP , mirroring apoptosis protection effects . Positive_regulation NFKB1 TNF 12481431 1024295 Sodium selenite and MeSeA , at the concentrations that induced apoptosis , inhibited [NF-kappa B] DNA binding *induced* by and lipopolysaccharide in DU145 and JCA1 prostate cells . Positive_regulation NFKB1 TNF 12508545 1027482 2. TPCK could inhibit the activation of [NF-kappa B] *induced* by . Positive_regulation NFKB1 TNF 12509469 1038723 Down regulation of endogenous RFC ( p140 ) inhibits expression from a chromosomally integrated reporter plasmid induced by endogenous , *activated* [NF-kappaB] . Positive_regulation NFKB1 TNF 12509805 1038772 Finally , IL-1beta and *induced* degradation of NF-kappaB 's bound inhibitory protein , IkappaB-alpha , leading to translocation of [NF-kappaB] into the nucleus . Positive_regulation NFKB1 TNF 12511413 1079061 The treatment of RAW264 cells with TSA and NaB inhibited *induced* nuclear translocation of [NF-kappa B] and sRANKL induced activation of p38 mitogen activated protein kinase (MAPK) signals . Positive_regulation NFKB1 TNF 12512958 1027731 Expression of the p75 TNF receptor is linked to *induced* [NFkappaB] translocation and oxyradical neutralization in glial cells . Positive_regulation NFKB1 TNF 12517920 1071013 IBOP abrogated *induced* [NFkappaB] activation in endothelial cells , as determined by reduced IkappaB phosphorylation and NFkappaB nuclear translocation , by inhibiting the assembly of signaling intermediates with the intracellular domain of TNF receptors 1 and 2 in response to TNFalpha . Positive_regulation NFKB1 TNF 12526096 1028239 To understand such conflicting effect of oxidative stress on NF- kappakB activation , HeLa cells were incubated with H ( 2 ) O ( 2 ) or diamide and *induced* expression of [NF-kappaB] reporter gene was measured . Positive_regulation NFKB1 TNF 12527815 1048503 This study shows that AEA inhibits induced [NF-kappaB] *activation* by direct inhibition of the IkappaB kinase (IKK)beta and , to a lesser extent , the IKKalpha subunits of kappaB inhibitor ( IkappaB) kinase complex , and that IKKs inhibition by AEA correlates with inhibition of IkappaBalpha degradation , NF-kappaB binding to DNA , and NF-kappaB dependent transcription in TNFalpha stimulated cells . Positive_regulation NFKB1 TNF 12531807 1079129 Delta TRAF6 and Delta MyD88 significantly abrogate antibody induced as well as IL-1- or LPS induced NF-kappa B activation , whereas Delta TRAF2 ( involved in [NF-kappa B] *activation* by ) does not affect it . Positive_regulation NFKB1 TNF 12555061 1051598 In this study , the basal and *induced* activation of [NF-kappaB] has been examined in cells overexpressing H-Ras , K-Ras or N-Ras . Positive_regulation NFKB1 TNF 12556975 1051796 *Activation* of [NF-kappaB] by prior to TRAIL exposure increased resistance of the cells to TRAIL mediated apoptosis . Positive_regulation NFKB1 TNF 12573143 1029608 Additionally , induced *activation* of [NF-kappaB] and AP-1 observed in ML-1a was greatly reduced in clone 19 . Positive_regulation NFKB1 TNF 12573143 1029611 These results indicate that mitochondrial respiratory function regulates induced and constitutive *activation* of [NF-kappaB] and AP-1 . Positive_regulation NFKB1 TNF 12574206 1057807 We hypothesize that may *induce* IL-8 production in endometriotic cells through [nuclear factor-kappa B (NF-kappa B)] activation . Positive_regulation NFKB1 TNF 12574206 1057814 The current study showed for the first time that GnRHa treatment attenuated the expression of IL-8 by reducing *induced* [NF-kappa B] activation . Positive_regulation NFKB1 TNF 12586352 1059019 Among others , the NF-kappa B-dependent zinc finger protein A20 is involved in the negative feedback regulation of [NF-kappa B] activation in *response* to . Positive_regulation NFKB1 TNF 12586352 1059025 We previously demonstrated that A20 can interact with A20 binding inhibitors of NF-kappa B activation ( ABINs ) , which have the potential to inhibit *induced* activation of [NF-kappa B] upon overexpression . Positive_regulation NFKB1 TNF 12586603 1059343 Moreover , bezafibrate repressed *induced* DNA binding activity of [NF-kappaB] . Positive_regulation NFKB1 TNF 12586603 1059345 Thus , fibrates reduced *induced* [NF-kappaB] activation and RANTES expression , possibly suggesting that fibrates might be inhibitory agents of migration of inflammatory cells by RANTES to the liver in patients with alcoholic liver diseases . Positive_regulation NFKB1 TNF 12592100 1029791 Activation is dose dependent and peaked at 30 min. Doses of Pefabloc sufficient to inhibit trypsin activation reduced CCK induced activation of NF-kappaB whereas *induced* [NF-kappaB] activation was not blocked but slightly increased . Positive_regulation NFKB1 TNF 12595760 1061712 An LKB1 interacting protein negatively regulates *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 12604244 1062591 Stimulation with *led* to the activation of the transcription factor [NF-kappaB] and enhanced VSMC growth . Positive_regulation NFKB1 TNF 12606638 1079734 Ad.N17Rac1 did not inhibit induced *activation* of [nuclear factor-kappaB (NF-kappaB)] binding activity or inhibitor of NF-kappaB-alpha degradation . Positive_regulation NFKB1 TNF 12606947 1062993 The treatment of these cells with adenosine suppressed *induced* [NF-kappaB] activation , but had no effect on activation of another redox-sensitive transcription factor , AP-1 . Positive_regulation NFKB1 TNF 12606947 1062995 The effect on *induced* [NF-kappaB] activation was selective as adenosine had minimal effect on NF-kappaB activation induced by H ( 2 ) O ( 2 ) , PMA , LPS , okadaic acid , or ceramide , suggesting differences in the pathway leading to NF-kappaB activation by different agents . Positive_regulation NFKB1 TNF 12606947 1062997 The suppression of *induced* [NF-kappaB] activation by adenosine was found not to be because of inhibition of TNF induced IkappaBalpha phosphorylation and degradation or IkappaBalpha kinase activation . Positive_regulation NFKB1 TNF 12606947 1063000 The suppression of *induced* [NF-kappaB] activation was unique to adenosine , as neither its metabolites ( inosine , AMP , and ATP ) nor pyrimidines ( thymidine and uridine ) had any effect . Positive_regulation NFKB1 TNF 12606947 1063002 Overall , our results clearly demonstrate that adenosine selectively suppresses induced [NF-kappaB] *activation* , which may contribute to its role in suppression of inflammation and of the immune system . Positive_regulation NFKB1 TNF 12627504 1066925 Sulindac inhibited mediated [NF-kappaB] *activation* and greatly sensitized MKN45 and HeLa cell lines to TNF-alpha . Positive_regulation NFKB1 TNF 12631113 1067604 The incubation of MCs with MG132 , a NF-kappaB inhibitor , abolished *induced* degradation of inhibitory protein of NF-kappaB ( I-kappaB)alpha , nuclear translocation of [NF-kappaB] , and fractalkine expression , without affecting phospho-c-Jun levels . Positive_regulation NFKB1 TNF 12631113 1067624 Additional experiments examining the role of cAMP on MC fractalkine expression showed that the incubation of MCs with TNF-alpha and either db-cAMP or forskolin attenuated TNF-alpha stimulated fractalkine mRNA and protein expression , preceded by attenuation of *activated* phosphorylation of p42/44 MAPK , and c-Jun , but not phosphorylation of PKCzeta/iota or nuclear translocation of [NF-kappaB] . Positive_regulation NFKB1 TNF 12635574 1068509 Our results indicated that production was *induced* by D. farinae in PBMCs of patients with atopic asthma by the activation of [NF-kappa B] via CD23 . Positive_regulation NFKB1 TNF 12637573 1091955 We have shown previously that strongly *induces* osteoclastogenesis of preosteoclasts and do so through activation of the transcription factor , [NF-kappaB] . Positive_regulation NFKB1 TNF 12646250 1069980 Ergothioneine inhibits oxidative stress- and *induced* [NF-kappa B] activation and interleukin-8 release in alveolar epithelial cells . Positive_regulation NFKB1 TNF 12646250 1069983 The aim of this study was to determine whether ergothioneine can inhibit the hydrogen peroxide ( H ( 2 ) O ( 2 ) ) - and mediated *activation* of [NF-kappa B] and the release of IL-8 in human alveolar epithelial cells ( A549 ) . Positive_regulation NFKB1 TNF 12646250 1069985 Ergothioneine inhibited both H ( 2 ) O ( 2 ) - and *mediated* activation of [NF-kappa B] . Positive_regulation NFKB1 TNF 12663241 1074457 clearly *up-regulated* RANTES expression in a time dependent fashion and induced DNA binding activity of [NF-kappaB] . Positive_regulation NFKB1 TNF 12665478 1074755 hALX transfected HEK293 cells transmitted LXA4 signals that inhibit *induced* [NFkappaB] activation . Positive_regulation NFKB1 TNF 12692090 1093274 Only at high concentrations , cPG enhanced TNF-alpha induced cell death and inhibited *induced* IkappaB-alpha kinase (IKK) activation , IkappaB-alpha degradation , and [NF-kappaB/p65] translocation , while promoting AP-1/c-jun phosphorylation . Positive_regulation NFKB1 TNF 12699902 1081662 We demonstrate in both cell types that *activates* [NF-kappaB] , and HQ exposure inhibits activation of NF-kappaB by TNF-alpha in a dose dependent manner . Positive_regulation NFKB1 TNF 12704649 1082362 In analogy with *dependent* activation of [NFkappaB] , treatment with either the anti-oxidant N-acetyl cysteine (NAC) or the cyclooxygenase (COX) inhibitor acetyl salicylic acid ( aspirin ) , but not indometacin , prevents the induction of NFkappaB dependent transcription by AII . Positive_regulation NFKB1 TNF 12706288 1082583 Moreover , , a secretory product of round spermatids , *stimulated* [NF-kappaB] binding to the AR promoter , induced AR promoter activity , and increased endogenous AR expression in primary cultures of Sertoli cells . Positive_regulation NFKB1 TNF 12706343 1082634 Activation of [NF-kappaB] in *response* to was intact in both cell lines . Positive_regulation NFKB1 TNF 12709429 1112680 The *role* of receptor associated factor ( TRAF)-1 in [NF-kappaB] activation by various members of the TNF receptor family is not well understood , and conflicting data have been published . Positive_regulation NFKB1 TNF 12709443 1100427 Using various deficient mouse embryonic fibroblast cells , we have compared the signaling pathways leading to [NF-kappaB] induction in *response* to and LTbetaR activation . Positive_regulation NFKB1 TNF 12712434 1083433 The *activation* of [NF-kappaB] through ligand induced stimulation by or phorbol 12-myristate 13-acetate ( PMA ) was also inhibited by transient expression of LDOC1 in a dose dependent manner . Positive_regulation NFKB1 TNF 12713738 1083479 SOCS-3 did not induce any alterations in [NF-kappaB] activity *induced* by LPS or . Positive_regulation NFKB1 TNF 12716675 1083752 The nuclear appearance of [p50-NFkappaB] and p65-NFkappaB acutely *induced* by was not modified by resveratrol but was increased after overnight incubation with resveratrol alone or in combination with TNF-alpha . Positive_regulation NFKB1 TNF 12716741 1083757 Strong T1D protection mediated at the beta-cell level characterized DL704/NOD mice lacking the E3 gp19K gene suppressing MHC class I expression but retaining the 10.4K , 14.5K , and 14.7K genes inhibiting Fas- or TNF-alpha induced apoptosis and induced [NF-kB] *activation* . Positive_regulation NFKB1 TNF 12716748 1083760 Recent studies incriminating tumor necrosis factor (TNF)-alpha as the final effector in pancreatic beta-cell death in type 1 diabetes underscore the potential role of *dependent* [NF-kappaB] activation as an important modulator of pancreatic beta-cell death in autoimmune diabetes . Positive_regulation NFKB1 TNF 12716748 1083764 The [NF-kappaB] DNA binding nuclear complex *activated* by contained both the p65 and p50 subunit . Positive_regulation NFKB1 TNF 12716748 1083766 IFN-gamma pretreatment did not affect *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 12717418 1083864 This DNA binding activity consisted primarily of RelB-p50 heterodimers , which was distinct from the [NF-kappa B] *activation* of . Positive_regulation NFKB1 TNF 12721308 1106521 TRADD also binds two other adaptors receptor interacting protein ( RIP ) and TNF-receptor associated factor 2 (TRAF2) , which are required for *induced* [NF-kappaB] and c-Jun N-terminal kinase activation , respectively . Positive_regulation NFKB1 TNF 12729461 1106712 *activated* [nuclear factor kappaB (NF-kappaB)] and induced fractalkine and CX3CR1 expression in a time dependent manner in rat aortic SMCs . Positive_regulation NFKB1 TNF 12729461 1106730 Taken together , our results demonstrate that induces the expression of fractalkine and CX3CR1 in rat aortic SMCs and that this induction is *mediated* by [NF-kappaB] activation . Positive_regulation NFKB1 TNF 12744771 1088519 U937 membranes , as well as IL-1beta and , *induced* nuclear translocation of [NF-kappaB] . Positive_regulation NFKB1 TNF 12748169 1113002 We demonstrate a critical role for FAK in the *induced* activation of [nuclear factor (NF)-kappaB] , using FAK-deficient ( FAK-/- ) embryonic fibroblasts . Positive_regulation NFKB1 TNF 12748169 1113008 Of note , *induced* [NF-kappaB] DNA binding activity and activation of IkappaB kinases ( IKKs ) were markedly impaired in FAK-/- cells , whereas the expression of TNF receptor I or other signaling molecules such as receptor interacting protein ( RIP ) , tumor necrosis factor receptor associated factor 2 ( TRAF2 ) , IKKalpha , IKKbeta , and IKKgamma was unchanged . Positive_regulation NFKB1 TNF 12748303 1089046 *induced* activation of [NF-kappaB] is accelerated in SODD-deficient cells , but TNF induced c-Jun N-terminal kinase activity is slightly repressed . Positive_regulation NFKB1 TNF 12753742 1090334 Recruitment of TNF receptor 1 to lipid rafts is essential for mediated [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 12761333 1091493 Both of these agents also reduced the activation of [NF-kappaB] *induced* by LPS , and interleukin-1beta in smooth muscle cells . Positive_regulation NFKB1 TNF 12761580 1091672 Immunostaining and EMSA revealed that [NF-kappaB] was *activated* strongly by compared to TNF alone in a human colon adenocarcinoma cell line , RPMI4788 . Positive_regulation NFKB1 TNF 12761580 1091678 On the other hand , Fas expression was strongly enhanced by TNF/IFN-alpha , and inhibition of *induced* [NF-kappaB] activation , by using NF-kappaB decoy , decreased Fas expression . Positive_regulation NFKB1 TNF 12767906 1094467 Indeed , TNF alpha induced NF-kappa B translocation was not sufficient to support enhancement of the transcription and des-IGF-1 did not promote but partly inhibited both the *induced* [NF-kappa B] activation and I kappa B alpha degradation through a PI-3K dependent pathway . Positive_regulation NFKB1 TNF 12773487 1095116 [NF-kappaB] binding to this sequence is *increased* by stimulation . Positive_regulation NFKB1 TNF 12775719 1119754 In transfection experiments , the CARD6 protein suppressed NF-kappa B induction by Nod1 or Cardiak but did not interfere with [NF-kappa B] *activation* by the CARD containing adapter protein Bcl10 or the cytokine , demonstrating specificity of CARD6 for Nod-1 and Cardiak dependent pathways . Positive_regulation NFKB1 TNF 12783888 1113513 In HEK293 cells , where can *activate* [NF-kappa B] , SNP likewise suppresses the binding of the active NF-kappa B complex , restoring the binding of the repressive p50/p50 homodimer complex . Positive_regulation NFKB1 TNF 12791476 1097687 We tested the hypothesis that fosfomycin inhibits the activation of [NF-kappaB] *induced* by in human monocytic U-937 cells , and a T cell line ( Jurkat ) . Positive_regulation NFKB1 TNF 12795658 1098440 Glimepiride dose dependent inhibition of carboxymethyllysin ( CML ) albumin or and H2O2 induced *activation* of [NF-kappaB] binding were determined , using isolated peripheral blood mononuclear cells from healthy volunteers , and transcriptional activity of bovine aortic endothelial cells either left untreated or induced with CML albumin incubated with or without glimepiride . Positive_regulation NFKB1 TNF 12801316 1101074 We examined whether or not pranlukast inhibits *induced* activation of nuclear transcription factor [NF-kappa B] , a factor that is essential for the expression of proinflammatory cytokines , on human monocytic 1.3 % dimethylsulphoxide ( DMSO ) -differentiated U-937 cells , which have cysteinyl LT1 (CysLT1) receptors on their membranes , and T cells ( Jurkat ) , which do not . Positive_regulation NFKB1 TNF 12801316 1101076 The inhibitory effects of pranlukast and MK-571 , which is an LTD4 receptor-selective antagonist , on *induced* [NF-kappa B] activation was evaluated by Western blotting and flow cytometry , and those on lipopolysaccharide (LPS) induced interleukin-6 (IL-6) production in peripheral blood mononuclear cells ( PBMC ) were evaluated by enzyme linked immunosorbent assaying . Positive_regulation NFKB1 TNF 12810884 1102857 Mutation of the TATA box had no effect on or RelA/p65 mediated *induction* of [NFkappaB-responsive] promoters , indicating a specific st-ag effect on hTAF ( II ) 130/135 . Positive_regulation NFKB1 TNF 12815168 1103428 Namely , JD inhibits *induced* activation of [NF-kappaB] in mouse 3T3 and human HeLa cells . Positive_regulation NFKB1 TNF 12816868 1140927 Although expression of mutant IkappaBalpha inhibited the *induced* [NF-kappaB] response , it had no effect on tumor growth in mice . Positive_regulation NFKB1 TNF 12851413 1134882 Oncoprotein suppression of *induced* [NF kappa B] activation is independent of Raf controlled pathways . Positive_regulation NFKB1 TNF 12851413 1134913 This suppression of NF kappa B is manifested by an inhibition of TNF induced inhibitor of NF kappa B ( IKK ) activity and NF kappa B DNA binding potential but not by blocking induced nuclear *accumulation* of [NF kappa B/p65] . Positive_regulation NFKB1 TNF 12851485 1109622 c-Myc and E2F1 inhibit [NF-kappaB] activities *induced* by or reactive oxygen species . Positive_regulation NFKB1 TNF 12859994 1111166 Since [nuclear factor-kappaB (NF-kappaB)] is *activated* by and induces expression of prosurvival genes , effects of the antisense oligodeoxynucleotides to NF-kappaB subunits , p65 and p50 , were examined . Positive_regulation NFKB1 TNF 12861043 1111700 Furthermore , cFLIP over-expression activated nuclear factor (NF)-kappaB and cFLIP down-regulation attenuated [NF-kappaB] activation *induced* by or TRAIL . Positive_regulation NFKB1 TNF 12867288 1112060 The [NF-kappaB] activation *induced* by MoCM and were inhibited by Se at the physiological levels . Positive_regulation NFKB1 TNF 12867288 1112064 The maximum activation of [NF-kappaB] was *induced* by or MoCM at a Se concentration ( 0.5 approximately 1 micromol/l ) which was half the level of the serum Se in healthy subjects and was equivalent to level in subjects with pathological conditions together with high serum CRP values . Positive_regulation NFKB1 TNF 12882985 1142761 Absence of apolipoprotein J causes reduction of IkappaB stability , a *dependent* increase in [NF-kappaB] activity , increased transcription of the NF-kappaB target gene c-IAP and down-modulation of p53 protein . Positive_regulation NFKB1 TNF 12885939 1116815 Moreover , [NF-kappaB] nuclear translocation *induced* by TRAIL but not by was abrogated by z-IETD-fmk , a caspase-8-specific inhibitor . Positive_regulation NFKB1 TNF 12890427 1117261 At the molecular level , EXPLY-37 did not inhibit the *activation* of the [nuclear factor kappa B (NF-kappaB)] transcription factor by . Positive_regulation NFKB1 TNF 12897154 1118428 Although TRAF2 is known to be required for induced JNK and [NF-kappaB] *activation* , the underlying mechanism of the increased sensitivity of TRAF2 null cells ( TRAF2 ( -/- ) ) to TNF induced apoptosis is not fully understood . Positive_regulation NFKB1 TNF 12900338 1121098 Infection of cardiomyocytes with an adenoviral vector ( Ad ) encoding A20 inhibited *stimulated* [NF-kappaB] signaling with an efficacy comparable to dominant negative inhibitor of kappa-B kinase beta ( dnIKKbeta ) . Positive_regulation NFKB1 TNF 12912861 1129498 and aims : *induction* of [nuclear factor kappaB (NFkappaB)] activation plays a major role in the pathogenesis of inflammatory bowel disease (IBD) . Positive_regulation NFKB1 TNF 12917341 1130560 Potentiation of *induced* [NF-kappa B] activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I kappa B alpha . Positive_regulation NFKB1 TNF 12917341 1130562 Here , we show that inhibitors of deacetylases such as trichostatin A (TSA) and sodium butyrate ( NaBut ) potentiated *induced* expression of several natural [NF-kappa B-driven] promoters . Positive_regulation NFKB1 TNF 12917341 1130564 Importantly , TSA prolonged both *induced* DNA binding activity and the presence of [NF-kappa B] in the nucleus . Positive_regulation NFKB1 TNF 12917420 1157669 Remarkably , we found that *activation* of [NF-kappaB] by selectively inhibited TCDD induced serine 2 phosphorylation in mouse liver cells , suggesting that residue-specific phosphorylation of RNA PII CTD at the cyp1a1 promoter is an important regulatory point upon which signal `` cross-talk '' converges . Positive_regulation NFKB1 TNF 12934647 1132835 IL-1beta and can *induce* extracellular signal regulated kinase ( ERK ) , IKK , IkappaB degradation and [NF-kappaB] activation . Positive_regulation NFKB1 TNF 12935892 1132872 Moreover , silymarin suppressed the *induced* DNA binding of [NF-kappaB/Rel] in HUVECs . Positive_regulation NFKB1 TNF 12941924 1133642 MCMV infection blocked *induced* nuclear translocation of [NF-kappaB] . Positive_regulation NFKB1 TNF 12947019 1151618 Because MEKK3 and Gab1 are critical for *induced* c-Jun and [NF-kappaB] activation , we determined the role of SHP-2 phosphatase activity in MEKK3 signaling . Positive_regulation NFKB1 TNF 12960255 1158295 To investigate a potential interplay between *induced* activation of p38 MAPK and [NF-kappaB] , the p38 MAPK inhibitor SB203580 and a dominant negative p38 MAPK mutant were used . Positive_regulation NFKB1 TNF 12960358 1138462 BA suppressed [NF-kappaB] activation *induced* by , PMA , cigarette smoke , okadaic acid , IL-1 , and H ( 2 ) O ( 2 ) . Positive_regulation NFKB1 TNF 1315830 185512 Inhibition of mediated [NF-kappa B] *activation* by selective blockade of the human 55-kDa TNF receptor . Positive_regulation NFKB1 TNF 1320006 190077 *activated* [NF-kappa B] , a nuclear factor thought to mediate multiple actions of TNF-alpha , in these cells with a maximum effect observed after 30 min of treatment . Positive_regulation NFKB1 TNF 13679039 1140201 Identification of a novel serine/threonine kinase that inhibits *induced* [NF-kappaB] activation and p53 induced transcription . Positive_regulation NFKB1 TNF 1431113 202792 These observations suggest that and PMA do not *lead* to [NF-kappa B] activation through induction of changes in the cell redox status . Positive_regulation NFKB1 TNF 14515147 1147028 In the SH-SY5Y cell line , neither *activated* [NFkappaB] nor induced MnSOD expression and activity , but was capable of modulating the IL-1 effects . Positive_regulation NFKB1 TNF 14522944 1148261 Previously , we demonstrated that [NF-kappaB] controls *mediated* suppression of myogenesis through a mechanism involving MyoD mRNA down-regulation . Positive_regulation NFKB1 TNF 14530285 1174844 , which *activates* both [NF-kappa B] and AP-1 , increased MAT2A expression in a dose- and time dependent manner , binding of both NF-kappa B and AP-1 to the MAT2A promoter and MAT2A promoter activity , with the latter effect blocked by site directed mutagenesis of the NF-kappa B and AP-1 binding sites . Positive_regulation NFKB1 TNF 14530285 1174847 Although blocking NF-kappa B had no influence on the ability of TNF alpha to increase AP-1 nuclear binding , blocking AP-1 with dominant negative c-Jun prevented the *mediated* increase in [NF-kappa B] binding . Positive_regulation NFKB1 TNF 14530343 1149246 We previously found that IL-4 and cooperate in the *activation* of STAT6 and [NF-kappaB] , suggesting that these transcription factors are regulated by common intracellular signaling pathways . Positive_regulation NFKB1 TNF 14532979 1152286 In the course of our screening for tumor necrosis factor-alpha (TNF-alpha) function inhibitors , conophylline , a vinca alkaloid isolated from the plant Ervatamia microphylla , was found to inhibit *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 14532979 1152288 We studied the effect of conophylline on *induced* [NF-kappaB] and JNK activations in human T-cell leukemia Jurkat cells . Positive_regulation NFKB1 TNF 14557256 1185995 receptor associated factor ( TRAF) 1 *regulates* CD40 induced TRAF2 mediated [NF-kappaB] activation . Positive_regulation NFKB1 TNF 14561767 1186190 Beta-catenin was translocated into the nucleus , whereas the *induced* nuclear translocation of [NFkappaB] was impaired . Positive_regulation NFKB1 TNF 14565866 1154980 The main transcript , which is ubiquitously expressed , encodes a protein that binds tumor necrosis factor receptor 1 ( TNF-R1 ) and downregulates *induced* activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 14566965 1155100 In both prechondrocytes and articular chondrocytes , *induced* concentration dependent activation of MEK1/2 and [NF-kappaB] , but not p38 or JNK . Positive_regulation NFKB1 TNF 14572618 1155843 In contrast , either the proteasome inhibitor carbobenzoxy-L-leucy-L-leucy-L-leucinal ( MG 132 ) or the IkappaBalpha inhibitor BAY 11-7082 ablated TNFalpha induced ICAM-1 gene expression and MG132 inhibited *induced* [NFkappaB] complexes . Positive_regulation NFKB1 TNF 14576080 1199902 Expression of N17Rac1 inhibited *induced* MCP-1 and [NF-kappaB] transcriptional activity . Positive_regulation NFKB1 TNF 14578185 1156656 NGF regulates nuclear factor (NF)-kappaB activity , reducing p50/p65 binding detected by electromobility shift assay and reduced NF-kappaB CAT reporter activities from both basal unstimulated levels and after [NF-kappaB] *induction* by . Positive_regulation NFKB1 TNF 14580690 1156972 Pretreating MKN45 cells with hyperthermia ( 42.0 degrees C ) significantly inhibited the *induced* increase in the binding activity of [NF-kappaB] to DNA . Positive_regulation NFKB1 TNF 14580690 1156974 This study suggests that hyperthermia can inhibit the *induced* [NF-kappaB] activation and that hyperthermia renders human gastric cancer cells susceptible to the TNF-alpha induced apoptosis , possibly via inhibition of the NF-kappaB pathway . Positive_regulation NFKB1 TNF 14584040 1187131 Furthermore , the overexpression of TrxR1 enhanced *induced* DNA binding activity of [NF-kappa B] and NF-kappa B-dependent gene expression . Positive_regulation NFKB1 TNF 14584040 1187134 The catalytic Sec residue of TrxR1 , which is essential for reducing Trx , was required for this NF-kappa B activation , and aurothiomalate , an inhibitor of TrxR , suppressed *induced* activation of [NF-kappa B] and the expression of NF-kappa B-targeted proinflammatory genes such as E-selectin and cyclooxygenase-2 . Positive_regulation NFKB1 TNF 14585846 1187154 This study investigated the significance of PI 3-kinase/Akt signaling to *induced* [NF-kappa B] activation in transformed , immortalized , and primary cells . Positive_regulation NFKB1 TNF 14585846 1187156 Pharmacological inhibition of PI 3-kinase blocked *induced* [NF-kappa B] DNA binding in the 293 line of embryonic kidney cells , partially affected binding in MCF-7 breast cancer cells , HeLa and ME-180 cervical carcinoma cells , and NIH 3T3 cells but was without significant effect in H1299 and human umbilical vein endothelial cells , cell types in which TNF activated Akt . Positive_regulation NFKB1 TNF 14599550 1161283 Furthermore , treatment of cells with these compounds prevented the *induced* expression of anti-apoptotic [NF-kappaB] target genes Bfl-1/A1 , a prosurvival Bcl-2 homologue , and resulted in sensitizing HT-1080 cells to TNF-alpha induced cell death . Positive_regulation NFKB1 TNF 14600157 1187537 [NF-kappaB] activation *induced* by , interleukin-1beta , and lipopolysaccharide was also inhibited by FAF1 overexpression . Positive_regulation NFKB1 TNF 14600158 1200278 Pretreatment of normal human intestinal lamina propria mononuclear cells ( LPMC ) with transforming growth factor-beta1 ( TGF-beta1 ) resulted in a marked suppression of *induced* [NF-kappaB] p65 accumulation in the nucleus , NF-kappaB binding DNA activity , and NF-kappaB dependent gene activation . Positive_regulation NFKB1 TNF 14600158 1200281 In marked contrast , treatment of LPMC from patients with inflammatory bowel disease with TGF-beta1 did not reduce *induced* [NF-kappaB] activation due to the overexpression of Smad7 . Positive_regulation NFKB1 TNF 14603259 1161756 Pharmacological blockade of the IKK2 kinase with AS602868 , a specific inhibitor that competes with ATP binding , prevented *induced* [NF-kappaB] activation in Jurkat leukemic T cells . Positive_regulation NFKB1 TNF 14607843 1200399 Depletion of TRP14 augmented the *induced* phosphorylation and degradation of I kappa B alpha as well as the consequent activation of [NF-kappa B] to a greater extent than did Trx1 depletion . Positive_regulation NFKB1 TNF 14607933 1162128 *dependent* activation of [NF-kappaB] is stronger in the presence of IFN-gamma . Positive_regulation NFKB1 TNF 14607933 1162135 STAT-1alpha associates with TNFR1 in TNF-alpha treated cells , and this association attenuates mediated [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 14607933 1162137 We hypothesized that nuclear localization of STAT-1alpha due to IFN-gamma signaling would preclude it from being recruited to the TNFR1 and therefore enhance *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 14607933 1162141 TNF-alpha treatment induces a more robust activation of NF-kappaB in STAT-1alpha-deficient cells , and restoration of STAT-1alpha inhibits *dependent* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 14613935 1187956 In contrast , *activated* [NF-kappaB] both in suspended cells and adherent cells . Positive_regulation NFKB1 TNF 14614151 1165541 A candidate gene in this region is A20 , which is involved in the feedback suppression of [NFkappaB] activation *induced* by . Positive_regulation NFKB1 TNF 14614151 1165543 NFkappaB reporter gene assays showed that this amino acid change results in less effective termination of *stimulated* [NFkappaB] activation by C57BL/6J-A20 . Positive_regulation NFKB1 TNF 14614151 1165546 In accordance , the *induced* expression of [NFkappaB] target genes ( A20 , IkappaBalpha ) in vascular smooth muscle cells was prolonged in cells isolated from C57BL/6J compared with FVB/N mice . Positive_regulation NFKB1 TNF 14617515 1200622 We previously demonstrated that exposing respiratory epithelial cells to 95 % oxygen ( hyperoxia ) synergistically increased mediated *activation* of [NF-kappaB] and NF-kappaB dependent gene expression by a mechanism involving increased activation of IkappaB kinase (IKK) . Positive_regulation NFKB1 TNF 14630924 1201123 [NF-kappaB] reporter activity *induced* by receptor 1 , TNF receptor associated death domain , TNF receptor associated factor-2 , NF-kappaB inducing kinase , and IkappaBalpha kinase , were all blocked by flavopiridol but not that activated by p65 . Positive_regulation NFKB1 TNF 14633987 1170872 Cotransfection of siRNAs directed against both TAB2 and TAB3 inhibit both IL-1- and *induced* activation of TAK1 and [NF-kappaB] . Positive_regulation NFKB1 TNF 14641910 1183808 Based on these data and on evidence from literature we suggest a model for the potential neurodegenerative effect of NF-kappaB in astroglia : *Activation* of [NF-kappaB] via results in a strongly increased production of MCP-1 . Positive_regulation NFKB1 TNF 14646384 1173131 Azelastine inhibits secretion of IL-6 , and IL-8 as well as [NF-kappaB] *activation* and intracellular calcium ion levels in normal human mast cells . Positive_regulation NFKB1 TNF 14656710 1210481 In contrast , markedly *increased* activation of [NF-kappaB] in both normal and Crohn 's cells . Positive_regulation NFKB1 TNF 14662828 1177601 Transfection of full-length CIAS1 or either of two shorter , naturally occurring isoforms dramatically inhibited *induced* activation of [NF-kappaB] reporter activity . Positive_regulation NFKB1 TNF 14662866 1177646 activation of NF-kappaB , in contrast , did not *increase* NGAL synthesis , even though induced binding of [NF-kappaB] to the NGAL promoter was observed in vitro . Positive_regulation NFKB1 TNF 14674885 1211097 The introduction of calcium into HEK293 cells either through the activation of muscarinic cholinergic receptors or through the application of the ionophore A23187 was found to enhance *dependent* activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 14676304 1178943 Because TRIP is an inhibitor of [nuclear factor (NF)-kappaB] *activation* by , the effect of CYLD on NF-kappaB activation was investigated in HeLa cells . Positive_regulation NFKB1 TNF 14684844 1211417 Moreover , we demonstrated that AT(2) receptor stimulation attenuated mediated [NF-kappaB] *activation* and MCP-1 expression . Positive_regulation NFKB1 TNF 14711835 1225496 We have identified two peptides from the p65 subunit of NF-kappaB ( P1 and P6 were from amino acid residues 271-282 and 525-537 , respectively ) that , when linked with a PTD derived from the third helix sequence of antennapedia , inhibited *induced* [NF-kappaB] activation in vivo . Positive_regulation NFKB1 TNF 14713911 1197167 Similarly , pNHP ( 73-102 ) decreased *induced* [NFkappaB] activation in NHBE cells . Positive_regulation NFKB1 TNF 14713952 1202642 Here , we demonstrate that TRAF2 ubiquitination is required for *induced* activation of JNK but not of p38 or [NF-kappaB] . Positive_regulation NFKB1 TNF 14715080 1225546 We observed that *activation* of [NF-kappaB] by ( tumour necrosis factor alpha ) inhibited both basal and androgen stimulated PSA expression , and that this down-regulation occurred at the promoter level , as confirmed by the super-repressor IkappaBalpha ( S32A/S36A ) , a dominant negative inhibitor of NF-kappaB . Positive_regulation NFKB1 TNF 14720501 1197834 Finally , *induced* activator protein-1 (AP-1) and [nuclear factor-kappaB (NF-kappaB)] activation and resultant intracellular adhesion molecule-1 ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) expressions were inhibited by ebselen . Positive_regulation NFKB1 TNF 14729457 1198429 Inhibition of p38 mitogen activated protein kinase reduces *induced* activation of [NF-kappaB] , elicits caspase activity , and enhances cytotoxicity . Positive_regulation NFKB1 TNF 14755547 1205634 Furthermore , the transactivation of *stimulated* [NF-kappaB] and AP-1 was inhibited by U0126 treatment . Positive_regulation NFKB1 TNF 14755547 1205642 Overexpression of RasN17 also abolished the *stimulated* [NF-kappaB] and AP-1 activity . Positive_regulation NFKB1 TNF 14764716 1207357 The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and mediated [NF-kappa B] *activation* through inhibiting phosphorylation of the I-kappa B kinase beta activation loop . Positive_regulation NFKB1 TNF 14764716 1207366 Also , LPS- and *induced* [NF-kappaB] transcription was inhibited by IKKgammaC417R . Positive_regulation NFKB1 TNF 14764716 1207368 Collectively , our results indicated that the zinc finger structure of IKKgamma plays a key role in LPS- and *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 14766535 1207579 Inhibition of *induced* [NF-kappa B] activation by selected NF-kappa B inhibitors , curcumin and triptolide , prevented the increase in Caco-2 TJ permeability , indicating that NF-kappa B activation was required for the TNF-alpha induced increase in Caco-2 TJ permeability . Positive_regulation NFKB1 TNF 14766965 1212046 Furthermore , the *activation* of [NF-kappaB] by TAB3 was blocked by the NF-kappaB inhibitor , SN50 , and by expression of dominant negative forms of alpha associated factor 6 and transforming growth factor beta activated kinase . Positive_regulation NFKB1 TNF 1482376 208237 Incubation of Jurkat T cells ( 1 x 10 ( 6 ) cells/ml ) with a natural thiol antioxidant , alpha-lipoic acid , prior to the stimulation of cells was found to inhibit [NF-kappa B] activation *induced* by ( 25 ng/ml ) or by phorbol 12-myristate 13-acetate ( 50 ng/ml ) . Positive_regulation NFKB1 TNF 14963056 1208752 The effect of eicosapentaenoic acid ( EPA ) , a major n-3 fatty acid in fish oil , on the lipopolysaccharide (LPS) induced expression of and *activation* of [NF-kappaB] were investigated . Positive_regulation NFKB1 TNF 14976147 1243034 Overexpression of the nuclear factor-kappaB (NFkappaB) p50 and/or p65 proteins increased the transcriptional activity of the beta-casein and WAP promoters in HC11 cells , suggesting that the inhibitory effect of on transcription of these genes is not *mediated* by [NFkappaB] . Positive_regulation NFKB1 TNF 14982564 1214343 Endotoxin caused transient production of and IL-6 and *activation* of [NF-kappaB] in the intestine at peak times of 1 , 4 and 1 h , respectively . Positive_regulation NFKB1 TNF 14984720 1214712 We examined the effects of SUN C8079 on the transcriptional responses of NF-kappaB , on *activation* of [NF-kappaB] in electrophoretic mobility shift assay , and on the gene expressions of and iNOS . Positive_regulation NFKB1 TNF 14985701 1214927 It has been reported that curcumin inhibits *induced* [NFkappaB] activity that is essential for Bcl-2 protein induction . Positive_regulation NFKB1 TNF 14985941 1228005 We examined whether or not IVIG inhibits *induced* activation of transcription factor [NF-kappaB] , a factor that is essential for the expression of proinflammatory cytokines , in human monocytic U-937 cells . Positive_regulation NFKB1 TNF 14985941 1228007 The inhibitory effect of IVIG on [NF-kappaB] activation *induced* by was evaluated by Western blotting and flow cytometry . Positive_regulation NFKB1 TNF 14985941 1228009 These findings suggest that IVIG inhibits *induced* [NF-kappaB] activation in monocytes/macrophages , and blocks FcgammaRIII on the membranes of monocytes/macrophages . Positive_regulation NFKB1 TNF 14991270 1215458 This study addresses the question whether the garlic metabolites diallyldisulfide ( DADS ) and allylmercaptane ( AM ) influence the *induced* activation of [NF-kappaB] and the NF-kappaB regulated endothelial gene product E-selectin in human umbilical endothelial cells ( HUVECs ) . Positive_regulation NFKB1 TNF 14995068 1182920 Differential involvement of ceramide in *mediated* activation of [NF-kappaB] in primary human keratinocytes and HaCaT keratinocytes . Positive_regulation NFKB1 TNF 14995068 1182922 It is well known that *activates* the transcription factor [NF-kappaB] , but there have been controversial reports on the role of ceramide in TNFalpha mediated NF-kappaB activation . Positive_regulation NFKB1 TNF 14995068 1182924 Here we show by different lines of experimental evidence that is a strong *inducer* of [NF-kappaB] in both cell types , whereas C2-ceramide failed to activate NF-kappaB in HaCaT keratinocytes in contrast to primary keratinocytes . Positive_regulation NFKB1 TNF 15001576 1236984 The receptor associated factor ( TRAF ) protein family members are critically *involved* in activation of [NF-kappaB] , JNK , and p38 activation triggered by tumor necrosis factor (TNF) receptor family members and toll/interleukin-1 receptor ( TIR ) -containing receptors . Positive_regulation NFKB1 TNF 15033450 1223450 EGCG did not influence *stimulated* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 15033733 1184088 We here demonstrate that sulindac inhibited mediated [NF-kappaB] *activation* and greatly enhanced TNF-alpha induced apoptosis in human gastric MKN45 and cervical HeLa carcinoma cell lines . Positive_regulation NFKB1 TNF 15044447 1251315 hCG treatment prevented the *dependent* [NF-kappaB] and AP-1 activation , which paralleled a decrease in the phosphorylation and degradation of IkappaBalpha . Positive_regulation NFKB1 TNF 15053878 1229834 Furthermore , UV-C and daunorubicin inhibit induced [NF-kappa B] *transactivation* , indicating that this is a dominant effect . Positive_regulation NFKB1 TNF 15056867 1230152 It was found that overexpression of Tom1 suppresses activation of transcription factors , [NF-kappaB] and AP-1 , *induced* by either IL-1beta or and that the VHS domain of Tom1 is indispensable for its suppressive activity . Positive_regulation NFKB1 TNF 15067740 1232058 [ Effect of Triptolide on *induced* activation of [NF-kappaB] and expression of COX-2 and iNOS in human rheumatoid arthritis synovial fibroblasts ] . Positive_regulation NFKB1 TNF 15068390 1184283 Kinetic experiments in HeLa cells show that stimulation first *induced* [NF-kappa B] DNA binding within 30 minutes , followed by I kappa B-alpha gene transcription 30 minutes later . Positive_regulation NFKB1 TNF 15068390 1184288 Removal of after stimulation *resulted* in a faster decrease in both [NF-kappa B] DNA binding activity and I kappa B-alpha mRNA levels . Positive_regulation NFKB1 TNF 15068815 1232318 Butyrate inhibited *induced* activation of [nuclear factor-kappaB (NF-kappaB)] in HUVEC . Positive_regulation NFKB1 TNF 15106733 1240549 plus IFN-gamma can *induce* extracellular signal regulated kinase ( ERK ) , IKK , IkappaB degradation and [NF-kappaB] activation . Positive_regulation NFKB1 TNF 15115707 1279363 Both kinases associate with TNFR-1 in *response* to and are required for TNFR-1 serine phosphorylation , [NF-kappaB] activation , and inhibition of apoptosis . Positive_regulation NFKB1 TNF 15117677 1279428 PKC-delta and -epsilon regulate [NF-kappaB] activation *induced* by cholecystokinin and in pancreatic acinar cells . Positive_regulation NFKB1 TNF 15117677 1279434 [NF-kappaB] *activation* by CCK-8 and required translocation but not tyrosine phosphorylation of PKC-delta . Positive_regulation NFKB1 TNF 15122760 1242296 CPT treatment completely abrogated the induced [NF-kappa B] *activation* , and mRNA expression of the antiapoptotic factors TNF-receptor associated factor 2 , FLICE-inhibitory protein , and X-linked inhibitor of apoptosis protein was also inhibited by CPT. The caspase inhibitors benzyloxycarbonyl-Val-Ala-Asp- ( OMe ) -fluoromethylketone ( zVAD-fmk ) and benzyloxycarbonyl-Asp ( OMe ) -Glu ( OMe ) -Val-Asp ( OMe ) -chloromethylketone ( zDEVD-fmk ) , as well as depletion of intracellular ATP by fructose prevented CPT/TNF induced apoptosis . Positive_regulation NFKB1 TNF 15131058 1245550 Apigenin also inhibited *induced* activation of [NF-kappaB] via the IkappaBalpha pathway , thereby sensitizing the cells to TNF-alpha induced apoptosis . Positive_regulation NFKB1 TNF 15140884 1252105 Downregulation of PIAS3 by RNA interference reverses its effect on mediated [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 15144120 1247555 In vitro expression of and *activation* of [NF-kappaB] in synovial fibroblasts after infection with Yersinia enterocolitica or Salmonella enteritidis was analysed by electrophoretic mobility shift assay , Western blot assay and real-time PCR . Positive_regulation NFKB1 TNF 15157676 1250594 SMase also augmented mediated [nuclear factor kappaB (NF-kappaB)] *activation* . Positive_regulation NFKB1 TNF 15161907 1273343 Our results show that mangiferin blocks *induced* [NF-kappaB] activation and NF-kappaB dependent genes like ICAM1 and COX2 . Positive_regulation NFKB1 TNF 15162831 1253061 These results indicate that endogenous production of in macrophages/monocytes is *required* for [NFkappaB] activation by irradiation . Positive_regulation NFKB1 TNF 15167811 1280257 , but not insulin , *led* to rapid activation of [NFkappaB] ( nuclear factor kappaB ) . Positive_regulation NFKB1 TNF 15167972 1253499 We examined whether or not IVIG inhibits *induced* activation of transcription factor [NF-kappaB] , a factor that is essential for the expression of proinflammatory cytokines , in human coronary artery endothelial cells ( CAEC ) . Positive_regulation NFKB1 TNF 15167972 1253501 The inhibitory effect of IVIG on [NF-kappaB] activation *induced* by was evaluated by Western blot analysis and ELISA . Positive_regulation NFKB1 TNF 15167972 1253506 Western blot analysis and ELISA demonstrated that IVIG inhibits [NF-kappaB] activation *induced* by in CAEC . Positive_regulation NFKB1 TNF 15167972 1253511 The data suggest that IVIG inhibits [NF-kappaB] activation *induced* by in CAEC , thereby possibly modulating IL-6 production and E-selectin expression . Positive_regulation NFKB1 TNF 15173580 1254227 Conversely , suppression of beta-arrestin 1 , but not beta-arrestin 2 , expression by using RNA interference led to a 3-fold increase in *stimulated* [NF-kappaB] activity as measured by NF-kappaB mobility-shift analysis . Positive_regulation NFKB1 TNF 15175554 1254918 Electrophoresis mobility shift assay ( EMSA ) and Western blot analysis showed that both the [nuclear factor-kappaB (NF-kappaB)] and the specificity protein-1 (SP-1) were *activated* by . Positive_regulation NFKB1 TNF 15175554 1254922 However , NAC only partially inhibited the *induced* activation of [NF-kappaB] , but abolished the activation of SP-1 . Positive_regulation NFKB1 TNF 15192014 1295265 These findings provide direct evidence that phosphorylation of p65 at S536 is required for *induced* [NF-kappaB] activation in the JB6 transformation model . Positive_regulation NFKB1 TNF 15208311 1281189 TNAP specifically inhibits [NF-kappaB] activation *induced* by , TNF receptor 1 , TRADD , RIP , TRAF2 , and NIK but does not affect IKK1- and IKK2 mediated NF-kappaB activation . Positive_regulation NFKB1 TNF 15208311 1281195 Knockdown of TNAP by lentiviral mediated small interference RNA potentiates *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 15208654 1281283 vIRF3 repressed NF-kappaB dependent transcription in a dose dependent manner and inhibited the activation of [NF-kappaB] *induced* by . Positive_regulation NFKB1 TNF 15209356 1261760 ( 10 ng/ml ) *increased* [NF-kappaB] DNA binding activity in nuclear extracts of osteoblasts . Positive_regulation NFKB1 TNF 15209356 1261764 The addition of NAC ( N-acetyl cysteine ) , free radical scavenger , completely prevented *induced* activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 15212763 1262304 We report that although *induced* [NF-kappaB] transcriptional activity is abolished in IKKgamma ( -/- ) cells , adenoviral gene delivery of NIK ( Ad5NIK ) still enhanced transcriptional activity and IL-6 mRNA accumulation . Positive_regulation NFKB1 TNF 15219804 1263966 Effects of antioxidants and nitric oxide on *induced* adhesion molecule expression and [NF-kappaB] activation in human dermal microvascular endothelial cells . Positive_regulation NFKB1 TNF 15219804 1263968 To evaluate the role of antioxidants and nitric oxide in modulating inflammatory processes in the skin , we examined the effects of pyrrolidine dithiocarbamate ( PDTC , 0.1 mM ) and spermine NONOate ( Sper-NO , 1 mM ) on adhesion molecule expression and [nuclear factor kappa B (NF-kappaB)] activation *induced* by ( 10 ng/ml ) in cultured human dermal microvascular endothelial cells ( HDMEC ) . Positive_regulation NFKB1 TNF 15219804 1263970 The mRNA expression of E-selectin , ICAM-1 and VCAM-1 , and activation of [NF-kappaB] *induced* by for 2 h were significantly decreased by the above two pretreatments . Positive_regulation NFKB1 TNF 15226458 1268833 However , if zinc was added back , all PPAR agonists significantly downregulated the mediated *induction* of inflammatory transcription factors [NF-kappaB] and AP-1 and significantly reduced the expression of their target genes , VCAM-1 and IL-6 . Positive_regulation NFKB1 TNF 15234187 1269470 In TNFalpha stimulated HUVEC , simvastatin decreased VCAM-1 and ICAM-1 mRNA levels , inhibited *induced* activation of [nuclear factor kappaB (NF-kappaB)] and enhanced expression of peroxisome proliferator activated receptor alpha ( PPARalpha ) . Positive_regulation NFKB1 TNF 15240695 1270290 *activates* Syk protein tyrosine kinase leading to TNF induced MAPK activation , [NF-kappaB] activation , and apoptosis . Positive_regulation NFKB1 TNF 15240695 1270326 Jurkat cells that did not express Syk ( JCaM1 , JCaM1/lck ) showed lack of *induced* Syk , JNK , p38 MAPK , and p44/p42 MAPK activation , as well as TNF induced IkappaBalpha phosphorylation , IkappaBalpha degradation , and [NF-kappaB] activation . Positive_regulation NFKB1 TNF 15240695 1270331 *induced* [NF-kappaB] activation was enhanced by overexpression of Syk by Syk-cDNA and suppressed when Syk expression was down-regulated by expression of Syk-small interfering RNA ( siRNA-Syk ) . Positive_regulation NFKB1 TNF 15240695 1270357 Overall , our results demonstrate that Syk activation plays an essential role in induced *activation* of JNK , p38 MAPK , p44/p42 MAPK , [NF-kappaB] , and apoptosis . Positive_regulation NFKB1 TNF 15252041 1289922 *induced* [NF-kappaB] reporter gene transcription was also suppressed in GSK-3beta gene deleted cells . Positive_regulation NFKB1 TNF 15256485 1322063 Such sensitization is closely associated with the inhibitory effect of PN on mediated [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 15256485 1322065 Our study revealed a new mechanism that PN inhibits mediated [NF-kappaB] *activation* via disrupting the recruitment of the IkappaB kinases (IKK) complex to TNF receptor , which then blocked the subsequent signaling events including IKK kinase activation , IkappaBalpha degradation , p65 nuclear translocation , DNA binding and transactivation . Positive_regulation NFKB1 TNF 15265936 1275713 Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates *induced* [NF-kappa B] activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma : correlation with suppression of COX-2 synthesis . Positive_regulation NFKB1 TNF 15265936 1275716 Akt activation , which is required for *induced* [NF-kappa B] activation , was also suppressed by this drug . Positive_regulation NFKB1 TNF 15276019 1276772 PEDF or an antioxidant , N-acetylcysteine , significantly inhibited the *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 15276019 1276780 The results demonstrated that PEDF inhibited induced [NF-kappaB] *activation* and subsequent IL-6 overexpression in HUVEC by suppressing NADPH oxidase mediated ROS generation . Positive_regulation NFKB1 TNF 15284221 1277878 Inhibition of AR abrogated TNF-alpha induced activation and membrane translocation of PKC , and antisense ablation of AR prevented both *induced* PKC and [NF-kappaB] activation . Positive_regulation NFKB1 TNF 15291876 1278735 CAPE prevented paclitaxel and mediated [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 15293554 1278956 This study also addresses PDTC and Sper-NO effects on activation of [nuclear factor kappa B (NF-kappaB)] *induced* by ( 10 ng/ml ) . Positive_regulation NFKB1 TNF 15293554 1278962 The mRNA accumulation of IL-8 , MCP-1 , RANTES , and eotaxin , and activation of [NF-kappaB] were *induced* by for 2 h ; Positive_regulation NFKB1 TNF 15310755 1303553 At the same time , the binding of AIP1 to TRAF2 inhibits *induced* [IKK-NF-kappaB] signaling . Positive_regulation NFKB1 TNF 15313421 1285505 In this context , we have previously demonstrated that deacetylase inhibitors ( HDACi ) synergize with *induced* [NF-kappaB] to activate the HIV-1 promoter . Positive_regulation NFKB1 TNF 15319427 1322734 Deletion of the ULD rendered IKKbeta catalytically inactive and unable to induce NF-kappaB activity , and overexpression of only the ULD dose-dependently inhibited *induced* [NF-kappaB] activity . Positive_regulation NFKB1 TNF 15322087 1323074 Guggulsterone suppressed DNA binding of [NF-kappaB] *induced* by , phorbol ester , okadaic acid , cigarette smoke condensate , hydrogen peroxide , and interleukin-1 . Positive_regulation NFKB1 TNF 15336952 1291318 Vitamin A may inhibit Sephadex induced lung granulomatous formation , and eosinophilic and neutrophilic infiltration due to its suppression of and eotaxin production , and [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 15337758 1323379 However , TRADD and RIP , which are essential for the *induced* [NF-kappaB] activation , were not involved in the FasL induced NF-kappaB activation . Positive_regulation NFKB1 TNF 15337758 1323390 Moreover , CLARP/FLIP inhibited the FasL- but not the *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 15355560 1293116 Mechanistic studies showed that ABD056 caused osteoclast apoptosis and inhibited induced [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 15367354 1297111 [ The inhibition of *induced* [NF-kappaB] nuclear translocation in ECV304 cells by mAbs against human TNF ] . Positive_regulation NFKB1 TNF 15367354 1297113 To identify the inhibition of *induced* [NF-kappaB] nuclear translocation by three anti-human TNF mAbs , D2 , E6 and F6 . Positive_regulation NFKB1 TNF 15367354 1297115 All of the three anti-TNF mAbs could inhibit *induced* [NF-kappaB] nuclear translocation in a dose dependent manner . Positive_regulation NFKB1 TNF 15367354 1297117 mAbs D2 , E6 and F6 can specifically inhibit *induced* [NF-kappaB] nuclear translocation , which lays the foundation for preparation of therapeutic chimeric anti-human TNF antibody for treatment of infectious and autoimmune diseases . Positive_regulation NFKB1 TNF 15383566 1298931 In the present report we investigated the effect of MDA-7 on NF-kappaB activation and on *induced* [NF-kappaB] activation and apoptosis in human embryonic kidney 293 cells . Positive_regulation NFKB1 TNF 15383566 1298935 However , *induced* [NF-kappaB] activation was significantly enhanced in mda-7 transfected cells , as indicated by DNA binding , p65 translocation , and NF-kappaB dependent reporter gene expression . Positive_regulation NFKB1 TNF 15383566 1298939 Cytoplasmic MDA-7 with deleted signal sequence was as effective as full-length MDA-7 in potentiating *induced* [NF-kappaB] reporter activity . Positive_regulation NFKB1 TNF 15383566 1298941 Secretion of MDA-7 was not required for the potentiation of *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 15383566 1298944 Overall , our results indicate that stable or transient MDA-7 expression alone does not substantially activate NF-kappaB , but potentiates *induced* [NF-kappaB] activation and NF-kappaB regulated gene expression . Positive_regulation NFKB1 TNF 15388451 1300346 We observed that PI pretreatment blocked the TLR2- and TLR4- as well as the *mediated* [NF-kappaB] activation , in a dose dependent manner . Positive_regulation NFKB1 TNF 15389516 1354250 P(3)-25 inhibited *induced* [NF-kappaB] activation as detected by gel shift assay and dependent reporter gene expression . Positive_regulation NFKB1 TNF 15451058 1300825 Ex vivo , zinc protected MNC from induced [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 15464842 1305167 In spite of this BZLF1 associated increase in the nuclear form of NF-kappaB , BZLF1 did not *induce* binding of [NF-kappaB] to NF-kappaB responsive promoters ( as determined by chromatin immunoprecipitation assay ) in vivo , although treatment induced NF-kappaB binding as expected . Positive_regulation NFKB1 TNF 15465831 1342239 BRE , brain and reproductive organ expressed protein , was found previously to bind the intracellular juxtamembrane domain of a ubiquitous death receptor , tumor necrosis factor receptor 1 ( TNF-R1 ) , and to down-regulate *induced* activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 15474016 1318807 We show here that A20 , a NF-kappaB-inducible zinc finger protein that has been demonstrated to be an inhibitor of *induced* [NF-kappaB] activation and a physiological suppressor of inflammatory response , potently inhibited TLR3- and Sendai virus mediated activation of ISRE and NF-kappaB and IFN-beta promoter in reporter gene assays . Positive_regulation NFKB1 TNF 15485901 1320805 alpha *induction* of [NF-kappaB] requires the novel coactivator SIMPL . Positive_regulation NFKB1 TNF 15489888 1342737 In the present study , we investigated the effect of almost a dozen different commonly used NSAIDs on *induced* [NF-kappaB] activation and NF-kappaB regulated gene products , and on cell proliferation . Positive_regulation NFKB1 TNF 15489888 1342739 All compounds inhibited *induced* [NF-kappaB] activation , but with highly variable efficacy . Positive_regulation NFKB1 TNF 15492857 1321722 The induced *activation* of c-Jun N-terminal kinase (JNK) , p38 , and [NF-kappaB] was not affected by Delta-1 stimulation . Positive_regulation NFKB1 TNF 15501764 1327088 In this regard , the ability of LT-IIbB to activate [NF-kappaB] and *induce* and IL-8 was antagonized by the LT-IIb holotoxin . Positive_regulation NFKB1 TNF 15504940 1327579 HGF also blunted *induced* nuclear translocation and activation of [NF-kappaB] , a pivotal transcription factor that regulates chemokine expression . Positive_regulation NFKB1 TNF 15518815 1328734 The subunits of NF-kappaB activated by TNF and WNV differed , WNV activated a p65/p50 NF-kappaB complex while *activated* [NF-kappaB] was composed of p65 , p50 , and c-Rel . Positive_regulation NFKB1 TNF 15518815 1328736 Furthermore , *induced* activation of [NF-kappaB] occurred earlier than WNV induced NF-kappaB activation . Positive_regulation NFKB1 TNF 15522867 1359773 We have recently identified an inducible [nuclear factor-kappaB (NF-kappaB)] regulator , IkappaB-zeta , which is *induced* by microbial ligands for Toll-like receptors such as lipopolysaccharide and the proinflammatory cytokine interleukin (IL)-1beta but not by . Positive_regulation NFKB1 TNF 15526279 1360001 Endothelial cell myosin light chain kinase (MLCK) regulates *induced* [NFkappaB] activity . Positive_regulation NFKB1 TNF 15526279 1360018 Both *induced* increase in NFkappaB dependent transactivation measured by NFkappaB luciferase reporter assay ( approximately fivefold ) and nuclear translocation of [NFkappaB] were significantly inhibited by MLCK-selective inhibitors , KT5926 ( 60 % inhibition of luciferase activity ) and ML7 ( 50 % decrease ) . Positive_regulation NFKB1 TNF 15526279 1360025 Furthermore , our data revealed that inhibition of MLCK attenuated the *induced* IkappaB phosphorylation , translocation of p65 , NFkappaB-DNA binding , and [NFkappaB] transcriptional activity . Positive_regulation NFKB1 TNF 15526279 1360029 Molecular approaches to either reduce EC MLCK expression ( AdV EC MLCK antisense construct ) or to reduce kinase activity ( kinase-dead EC MLCK ATPdel mutant ) produced similar attenuation of the *induced* [NFkappaB] response . Positive_regulation NFKB1 TNF 15526279 1360033 Together , these novel observations indicate that TNFalpha induced cytoskeletal rearrangement driven by MLCK activity is necessary for *dependent* [NFkappaB] activation and amplification of pro-survival signals . Positive_regulation NFKB1 TNF 15530848 1332711 In contrast , antioxidants did not prevent *induced* Akt and [NF-kappaB] activation . Positive_regulation NFKB1 TNF 15542663 1337443 Previous findings from this laboratory demonstrated that the E3 proteins 10.4K and 14.5K , which form a complex in the plasma membrane , inhibit induced *activation* of [NF-kappaB] and the synthesis of chemokines . Positive_regulation NFKB1 TNF 15550448 1367858 [NF-kappaB] , an inhibitor of the type I collagen promoters , is *increased* by both acetaldehyde and . Positive_regulation NFKB1 TNF 15550448 1367860 This study determined the effects of acetaldehyde in comparison to the effects of on inhibitory kappa B-alpha ( IkappaB-alpha ) protein and [NF-kappaB] *activation* in hepatic stellate cells . Positive_regulation NFKB1 TNF 15550448 1367864 Both acetaldehyde and *enhanced* nuclear [NF-kappaB] ( p65 ) , but acetaldehyde alone also increased NF-kappaB ( p50 ) . Positive_regulation NFKB1 TNF 15550448 1367866 and acetaldehyde independently *activate* [NF-kappaB] by rapid enhancement of IkappaB-alpha kinase activity and degradation of IkB-alpha protein . Positive_regulation NFKB1 TNF 15554267 1338743 Vitamin C blocks induced [NF-kappaB] *activation* and ICAM-1 expression in human neuroblastoma cells . Positive_regulation NFKB1 TNF 15554267 1338746 Moreover , a gel shift analysis indicated that vitamin C dose-dependently inhibited the [NF-kappaB] activation and IkappaBalpha degradation *induced* by . Positive_regulation NFKB1 TNF 15557193 1340492 In parallel studies we observed that inhibition of the RhoA/ROCK pathway by the same pharmacological and genetic approaches failed to inhibit induced [NF-kappaB] *activation* and ICAM-1 expression . Positive_regulation NFKB1 TNF 15563986 1341373 Furthermore , *activated* [nuclear factor-kappaB (NF-kappaB)] , known as a downstream effector of PKCzeta to 256.6 % , which was enhanced with overexpression of wild-type PKCzeta . Positive_regulation NFKB1 TNF 15572679 1344361 Receptor interacting protein ( RIP ) plays a critical role in *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 15572679 1344363 We found that *induced* [NF-kappaB] activation was fully restored by MEKK3-DD in these cells . Positive_regulation NFKB1 TNF 15572679 1344367 In contrast , expression of a fusion protein composed of NEMO , a component of the IkappaB kinase complex , and the death domain of RIP ( NEMO-DD ) can not restore *induced* [NF-kappaB] activation in RIP-deficient cells . Positive_regulation NFKB1 TNF 15572679 1344369 These results indicate that the role of RIP is to specifically recruit MEKK3 to the TNF-alpha receptor complex , whereas the forced recruitment of NEMO to the TNF-alpha receptor complex is insufficient for *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 15572679 1344371 Although MEKK2 has a high degree of homology with MEKK3 , MEKK2-DD , unlike MEKK3-DD , also fails to restore *induced* [NF-kappaB] activation in RIP-deficient cells , indicating that RIP dependent recruitment of MEKK3 plays a specific role in TNF-alpha signaling . Positive_regulation NFKB1 TNF 15581626 1345183 As oxidative stress is one of the most prominent activators of JNK , we investigated the relationship between *induced* [NF-kappaB] activation and the control of oxidative stress . Positive_regulation NFKB1 TNF 15589482 1356220 In addition , luteolin inhibited *induced* phosphorylation of p38 MAPK and extracellular regulated kinases (ERK) , IkappaB degradation , and [NF-kappaB] activation . Positive_regulation NFKB1 TNF 15592525 1361663 Here , we addressed the role of endogenous caspase-8 in induced *activation* of [NF-kappaB] . Positive_regulation NFKB1 TNF 15592525 1361669 Direct targeting of caspase-8 with siRNA and antisense ( AS ) approaches abolished *induced* activation of [NF-kappaB] in NIH3T3 , HeLa , and HEK293 cells as determined with luciferase reporter gene and cell fractionation assays . Positive_regulation NFKB1 TNF 15592525 1361676 Taken together , these results suggest that endogenous caspase-8 mediates *induced* activation of [NF-kappaB] via FLASH . Positive_regulation NFKB1 TNF 15593196 1346314 These studies were performed to determine if *induced* [NF-kappaB] controls the expression of FLIP long ( FLIP ( L ) ) and FLIP short ( FLIP ( S ) ) in RA synovial fibroblasts and to determine the role of FLIP in the control of TNFalpha induced apoptosis . Positive_regulation NFKB1 TNF 15596807 1356611 Like E1A , E6 has been reported to sensitize cells to lysis by TNF-alpha by inhibiting the induced *activation* of [NF-kappaB] . Positive_regulation NFKB1 TNF 15596807 1356613 We found that E1A , but not E6 , blocked the *induced* activation of [NF-kappaB] , an activity that correlated with E1A-p300 binding . Positive_regulation NFKB1 TNF 15604270 1346848 In tubular LLC-PK(1) cells , *activation* of [nuclear factor kappaB (NFkappaB)] by resulted in HIF-1alpha protein synthesis as determined by [ ( 35 ) S ] methionine pulse experiments . Positive_regulation NFKB1 TNF 15616312 1357502 Within 6 h of exposure , and N-9 *triggered* [NF-kappaB] and AP-1/cFos activation and upregulated interleukins and an array of chemokines by vaginal and polarized cervical epithelial cells . Positive_regulation NFKB1 TNF 15642133 1363097 EGF alone did not activate NF-kappaB or alter [NF-kappaB] *activation* by . Positive_regulation NFKB1 TNF 15647756 1363641 In this study , we have compared induced *activation* of [NF-kappaB] , phosphorylation of IkappaBalpha , and the expression of IKKbeta between lymphocytes from young and aged humans . Positive_regulation NFKB1 TNF 15648785 1350027 The results showed that LPS elevated the production of , IL-6 , and IL-10 and enhanced [NF-kappaB] *activation* in rat intestine . Positive_regulation NFKB1 TNF 15650392 1364022 Tumor necrosis factor-alpha (TNFalpha) and hydrogen peroxide ( H2O2 ) both activated p38 , but only *activated* [nuclear factor-kappaB (NF-kappaB)] . Positive_regulation NFKB1 TNF 15650393 1364031 Studies of nuclear factor-kappaB (NFkappaB) activation , an essential event in IL-8 production , showed decreased *induced* [NFkappaB] activation by acrolein , illustrated by inhibition of nuclear translocation of NFkappaB and reduced IkappaBalpha degradation . Positive_regulation NFKB1 TNF 15650394 1364037 Curcumin inhibited both H2O2- and mediated *activation* of [NF-kappaB] and AP-1 , and IL-8 release . Positive_regulation NFKB1 TNF 15657077 1364648 Overexpression of TRIP6 potentiates NF-kappaB activation by TNF , IL-1 , TLR2 or Nod1 , whereas a dominant negative mutant or RNA-interference construct of TRIP6 inhibits [NF-kappaB] *activation* by , IL-1 , TLR2 or Nod1 . Positive_regulation NFKB1 TNF 15662752 1350348 It became known , that oxidized LDL can inhibit LPS induced binding of the NF-kappaB to DNA and the subsequent expression of and interleukin-1beta in macrophages as well as oxidized LDL modulates *activation* of [NF-kappaB] in mononuclear phagocytes by altering the degradation of I-kappaBs . Positive_regulation NFKB1 TNF 15664394 1365242 However , only *activated* [NF kappa B] . Positive_regulation NFKB1 TNF 15665513 1365450 However , the existence of this inhibitory JNK pathways suggests a mechanism whereby -- in the absence of [NF-kappaB] *activation* -- production during inflammation in vivo could actually inhibit MUC2 production , giving rise to the defective mucosal protection which characterizes inflammatory bowel disease . Positive_regulation NFKB1 TNF 15665514 1365460 Because the endotoxin stress response in ventricular myocytes involves the upregulation of , and the *activation* of [NF-kappaB] , the effects of rosiglitazone on lipopolysaccharide induced NF-kappaB dependent transcription were also investigated . Positive_regulation NFKB1 TNF 15670894 1366051 Pretreating Colon 26 cells with IL-10 significantly attenuated the *induced* [NF-kappa B] activation . Positive_regulation NFKB1 TNF 15671209 1366100 Phloretin did not affect *stimulated* activation of [nuclear factor kappaB (NF-kappaB)] but inhibited activation of interferon regulatory factor 1 , a transcription factor involved in the regulation of endothelial cell adhesion molecule expression . Positive_regulation NFKB1 TNF 15677444 1395383 We identified importin alpha3 and importin alpha4 as the main importin alpha isoforms mediating *stimulated* [NF-kappaB] p50/p65 heterodimer translocation into the nucleus . Positive_regulation NFKB1 TNF 15683721 1370652 All three cytokines alone induced the activation of AP-1 while IL-1beta and but not IFN-gamma *induced* the activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 15684769 1350956 These results suggest that may be an *inducer* of [NF-kappaB] activation and MnSOD expression after SCI and that MnSOD expression induced by TNF-alpha is likely mediated through activation of NF-kappaB . Positive_regulation NFKB1 TNF 15687330 1402546 3 ) activation *induced* increased nuclear translocation of [NF-kappaB] , which was inhibited by pretreatment with either Thal or N-tosyl-L-phenylalanine chloromethyl ketone , an NF-kappaB inhibitor . Positive_regulation NFKB1 TNF 15687330 1402549 The current study showed for the first time that Thal treatment attenuated the expression of IL-8 by reducing *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 15687488 1382422 Reduction of the protein level of endogenous CPAP by RNA interference resulted in decreased *activation* of [NF-kappaB] by . Positive_regulation NFKB1 TNF 15695400 1371848 Moreover , CLIC4-antisense induction increased TNFalpha mediated apoptosis in both the SaOS and U2OS derivative cell lines without altering *induced* [NFkappaB] activity . Positive_regulation NFKB1 TNF 15696169 1372176 Using TCPTP-deficient fibroblasts , we show here that TCPTP regulates *induced* MAPK but not [NF-kappaB] signaling . Positive_regulation NFKB1 TNF 15698590 1372320 However , the effects of statin on the expression of and *activation* of [NF-kappaB] in endothelial cells stimulated by CRP are less studied . Positive_regulation NFKB1 TNF 15698590 1372332 CRP stimulation result in induction of and *activation* of [NF-kappaB] , and this effect could be significantly inhibited by fluvastatin , suggesting that CRP may play a direct role in atherogenesis by activating endothelial cells , and statins inhibit this response , which may provide an insight into the mechanisms of anti-inflammatory or anti-atherosclerotic actions of statins . Positive_regulation NFKB1 TNF 15699580 1376340 In addition , SH inhibited the increase of *induced* [NF-kappaB] protein levels , transcription factor of TNF-alpha from 293T cells . Positive_regulation NFKB1 TNF 15701708 1388734 AGIX-4207 did not inhibit *induced* nuclear translocation of nuclear factor of the kappa-enhancer in B cells ( [NF-kappaB] ) , suggesting that the mechanism of action is independent of this redox-sensitive transcription factor . Positive_regulation NFKB1 TNF 15709200 1373291 In this cell line , DHMEQ completely inhibited the *induced* activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 15722197 1374644 The *activation* of [NF-kappaB] and phosphatidylinositol-3 (PI3) kinase by and TRAIL overrides the pro-apoptotic effects of these ligands in carcinoma cells and hinders their therapeutic application . Positive_regulation NFKB1 TNF 15723296 1376699 In Myd88 ( -/- ) mice after PH , induction of expression of immediate early genes involved in hepatocyte replication and phosphorylation of STAT3 in the liver , and production of by and *activation* of [NF-kappaB] in the Kupffer cells were grossly subnormal and were associated with impaired liver regeneration . Positive_regulation NFKB1 TNF 15727562 1416781 *caused* maximal nuclear translocation of [NF-kappaB] within 15 min , compared with 1 h in cells pretreated with MitoVit E . Positive_regulation NFKB1 TNF 15728492 1377304 Taken together our results suggest a model in which IFN-gamma induced *activates* [NF-kappaB] , which is required for full COX-2 expression . Positive_regulation NFKB1 TNF 15731292 1439215 The inflammatory cell infiltrate , blood vessel formation , and angiogenic factors , [NF-kappaB] *activation* , expression of and interleukin 1beta (IL1beta) , and the presence of cyclo-oxygenase (COX)-1 and COX-2 were quantified . Positive_regulation NFKB1 TNF 15743837 1379131 Here we report that eIF4GI , which is a scaffold protein interacting with many translation factors , interacts with TRAF2 , a signaling molecule that plays a key role in *activation* of [NF-kappaB] through . Positive_regulation NFKB1 TNF 15755871 1397100 Finally , we show that beta2-integrins , which are not necessary for induced [NF-kappaB] *activation* at 37 degrees C , transduce costimulatory signals allowing NF-kappaB activation after heat exposure . Positive_regulation NFKB1 TNF 1577874 187551 Furthermore , could still *activate* [NFkB] in this variant , suggesting that this pathway is not involved in TNF mediated cytotoxicity . Positive_regulation NFKB1 TNF 15791843 1352663 To investigate the effect of N-tosyl-L-phenylalanylchloromethyl ketone ( TPCK ) on *induced* [NF-kappaB] activation and apoptosis in U937 cell line , changes and subcellular localization of NF-kappaB/p65 and IkappaB-alpha were observed by fluorescencemicroscopy and expression and degradation of IkappaB-alpha by flow cytometry . Positive_regulation NFKB1 TNF 15802795 1390725 Treatments of xanthoangelol D but not xanthoangelol , xanthoangelol E and F markedly suppressed both of basal and *induced* [NF-kappaB] activation in PAECs . Positive_regulation NFKB1 TNF 15811852 1410609 In this study , we investigated recruitment of coactivators ( SRC-1 , SRC-2 , and SRC-3 ) and corepressors ( HDAC1 , HDAC2 , HDAC3 , SMRT , and NCoR ) to the IkappaB alpha gene promoter after [NF-kappaB] *activation* by . Positive_regulation NFKB1 TNF 15818692 1393481 induced *activation* of [NF-kappaB] and AP-1 was decreased in the primary dermal fibroblasts with the C43S TNFRSF1A mutation . Positive_regulation NFKB1 TNF 15823455 1393895 We therefore evaluated the effects of pyrrolidine dithiocarbamate ( PDTC ; 0.1 mM ) and spermine NONOate ( Sper-NO ; 1 mM ) on adhesion molecule expression and [nuclear factor kappa B (NF-kappaB)] activation *induced* by ( 10 ng/ml ) in cultured human pulmonary microvascular endothelial cells ( PMVEC ) . Positive_regulation NFKB1 TNF 15823455 1393897 The mRNA expression of E-selectin , ICAM-1 and VCAM-1 , and activation of [NF-kappaB] *induced* by for 2 h were decreased significantly by the above two pretreatments . Positive_regulation NFKB1 TNF 15824857 1394063 Only a few TRACP ( + ) multinucleate cells were formed , and mediated *activation* of JNK , [NF-kappaB] , and NFATc1 was defective . Positive_regulation NFKB1 TNF 15828019 1425363 To search for new approaches to limit cartilage damage , we investigated the requirement of polyamines for [NF-kappaB] *activation* by in human C-28/I2 chondrocytes , using alpha-difluoromethylornithine ( DFMO ) , a specific polyamine biosynthesis inhibitor . Positive_regulation NFKB1 TNF 15837794 1432557 Expression of this protein inhibited induced *activation* of [NFkappaB] , JNK , and p38 MAPK and sensitized the cells to TNF induced apoptosis . Positive_regulation NFKB1 TNF 15855164 1425579 Finally , Dok-4 enhanced mediated [NF-kappaB] *activation* , whereas this was inhibited by transfection with Dok-4 small interfering RNA . Positive_regulation NFKB1 TNF 15855164 1425585 These data suggest a role for mitochondrial Dok-4 as an anchoring molecule for the tyrosine kinase c-Src , and in turn as a regulator of *mediated* ROS production and [NF-kappaB] activation . Positive_regulation NFKB1 TNF 15864742 1401420 ECs infected with Ad-RacN17 attenuated the *induced* [NFkappaB] binding activity . Positive_regulation NFKB1 TNF 15866594 1402056 The present study demonstrates for the first time that P and progestational compounds attenuate the expression of IL-8 by reducing *induced* [NF-kappaB] activation in endometriotic stromal cells , suggesting a possible molecular mechanism of hormone therapy for controlling the growth of endometriosis . Positive_regulation NFKB1 TNF 15867352 1402117 Further , we showed that suppression of both constitutive and *induced* [NF-kappaB] activation by BRMS1 may be due to inhibition of IkappaBalpha phosphorylation and degradation . Positive_regulation NFKB1 TNF 15870903 1405555 In addition , GA inhibited *induced* phosphorylation of p38 MAPK and extracellular regulated kinases (ERK) , I kappa B alpha degradation , and [NF-kappa B] activation . Positive_regulation NFKB1 TNF 15878280 1411329 Compound 3 proved active in selectively inhibiting the *induction* of [NF-kappaB] by in T cells . Positive_regulation NFKB1 TNF 15879145 1406061 In this study we demonstrate that a highly purified low endotoxin pancreatic elastase preparation ( El-UP ) failed both to activate [NF-kappaB] and to *induce* release in RAW 264.7 cells and bone marrow derived macrophages . Positive_regulation NFKB1 TNF 15879156 1406165 Gene transfer of TIMP-3 inhibits the induced *activation* of [NF-kappaB] in rheumatoid arthritis synovial fibroblasts and reduces the up-regulation of soluble Fas/CD95 by TNF-alpha , but has no effects on the cell surface expression of Fas . Positive_regulation NFKB1 TNF 15893971 1407695 We generated transgenic mice carrying a C-terminal deleted form of PW1 ( DeltaPW1 ) which blocks p53 mediated cell death and mediated [NFkappaB] *activation* fused to the myogenin promoter . Positive_regulation NFKB1 TNF 15897777 1408647 In addition , ESM also significantly inhibited *induced* translocation of [nuclear factor kappaB (NF-kappaB)] from cytoplasm to nuclei in endothelial cells . Positive_regulation NFKB1 TNF 15913942 1465008 In comparison , LPS induced a much greater activation of [NF-kappaB] and TNFalpha promoters , and secretion into the supernatant was strongly *induced* . Positive_regulation NFKB1 TNF 15918511 1413269 In addition , using the SEAP ( Secreted alkaline phosphatase ) assay system , we investigated the in vitro anti-inflammatory activity of the 70 % ethanol extract of the roots of S. bockii , which showed moderate activity in inhibiting *induced* [NF-kappaB] activation with an IC50 value of 166.6 microg/mL . Positive_regulation NFKB1 TNF 15922994 1427216 We also observed that tropisetron is a potent inhibitor of PMA plus ionomycin induced NF-(kappa)B activation but in contrast mediated [NF-(kappa)B] *activation* was not affected by this antagonist . Positive_regulation NFKB1 TNF 15934029 1414643 An aqueous stem bark extract of Mangifera indica ( Vimang ) inhibits T cell proliferation and induced *activation* of nuclear transcription factor [NF-kappaB] . Positive_regulation NFKB1 TNF 15934029 1414647 Moreover , the extract prevented *induced* IkappaBalpha degradation and the binding of [NF-kappaB] to the DNA . Positive_regulation NFKB1 TNF 15943618 1415871 *mediated* activation of [NF-kappaB] has been proposed to be one pathway leading to transcriptional activation of CMV ie gene expression . Positive_regulation NFKB1 TNF 15949909 1465026 Addition of purified NSmase to ANA-1 cell cultures stimulated [NFkappaB] binding , increased transcriptional activity in cells transfected with NFkappaB responsive promoters , and *induced* expression . Positive_regulation NFKB1 TNF 15950952 1427655 The selective impact of HDAC inhibitors on induced [NF-(kappa)B] *activation* appears to relate to the fact that the TNF-alpha induced activation of NF-(kappa)B is mediated by the proteasome , whereas NF-kappaB activation by IL-1beta is largely proteasome independent . Positive_regulation NFKB1 TNF 15951441 1440623 NIBP overexpression potentiates *induced* [NF-kappaB] activation through increased phosphorylation of the IKK complex and its downstream I(kappa)B(alpha) and p65 substrates . Positive_regulation NFKB1 TNF 15951441 1440629 Finally , knockdown of NIBP expression by small interfering RNA reduces *induced* [NF-kappaB] activation , prevents nerve growth factor induced neuronal differentiation , and decreases Bcl-xL gene expression in PC12 cells . Positive_regulation NFKB1 TNF 15953363 1421744 It inhibits *induced* PI3-kinase , Akt and [NF-kappaB] activation in these cells . Positive_regulation NFKB1 TNF 15975820 1434701 IL-17 also inhibited the *mediated* expression of adhesion molecule VCAM-1 , and the [NF-kappaB] binding to the VCAM-1 promoter-specific site , along with the inhibitor of NF-kappaB , IkappaB-beta . Positive_regulation NFKB1 TNF 15979856 1452535 In order to study the relationship between the constitutively active NF-kappaB and IkappaB-alpha , a dominant negative mutant IkappaB-alpha ( IkappaB-alphaDN ) , lacking the N-terminal 36 amino acids required for the *activation* of [NF-kappaB] by , was expressed in the Daudi cells . Positive_regulation NFKB1 TNF 15980038 1465249 Fas associated death-domain protein inhibits *mediated* [NF-kappaB] activation in cardiomyocytes . Positive_regulation NFKB1 TNF 15980038 1465275 FADD expression also inhibited mediated [NF-kappaB] *activation* in human endothelial cells but not in rat pulmonary artery smooth muscle cells . Positive_regulation NFKB1 TNF 15987860 1429156 LGG reduced the *induced* [NFkappaB] translocation to the nucleus and lessened the decrease in IkappaB in the cytoplasm ( P < 0.05 ) . Positive_regulation NFKB1 TNF 16006484 1459282 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the transcription factor ( [NF-kappaB] ) in lung tissue before and for 2 h after endotoxin . Positive_regulation NFKB1 TNF 16007145 1465533 We found that zerumbone suppressed [NF-kappaB] activation *induced* by , okadaic acid , cigarette smoke condensate , phorbol myristate acetate , and H2O2 and that the suppression was not cell type specific . Positive_regulation NFKB1 TNF 16011481 1459395 *induces* [NF-kappaB] ( nuclear factor kappaB ) and AP-1 ( activator protein 1 ) nuclear binding activities . Positive_regulation NFKB1 TNF 16012749 1431684 Furthermore , exogenously added ATIII induced a G-protein coupled signal transduction process in CD4+ T-cells and inhibited *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 16018991 1465695 Moreover , ghrelin inhibited *induced* activation of [nuclear factor-kappaB (NF-kappaB)] in HUVECs . Positive_regulation NFKB1 TNF 16020544 1453194 superfamily receptors typically *induce* both [NF-kappaB] and JNK activation by recruiting the TRAF2 signal transduction protein to their cytoplasmic domain . Positive_regulation NFKB1 TNF 16025521 1435671 This dual function of NF-kappaB emphasizes the need for therapeutics that can inhibit both *induced* [NF-kappaB] activation and cell death . Positive_regulation NFKB1 TNF 16027228 1465984 We found that UVB , IL-1 , and *induced* [NF-kappaB] activation and then produced MMP-1 and bFGF in HaCaT keratinocytes and skin fibroblasts . Positive_regulation NFKB1 TNF 16033420 1436117 3-OMS also inhibited [nuclear factor kappaB (NF-kappaB)] binding activity *induced* by or by the combination of TNF-alpha and Abeta . Positive_regulation NFKB1 TNF 16040075 1453588 Tumor necrosis factor ( ) *triggers* biphasic activation of the [NF-kappaB] transcriptional regulator . Positive_regulation NFKB1 TNF 16040075 1453590 This ability was attributed to blockage of the persistent phase of *induced* [NF-kappaB] activation for the following reasons : ( 1 ) the initial phase of NF-kappaB transcriptional activation was not affected by the MC159 protein ; Positive_regulation NFKB1 TNF 16040075 1453592 In contrast , MC159-TRAF2 associations are more relevant for inhibitory function since mutant MC159 proteins unable to bind TRAF2 also can not inhibit mediated [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 16041832 1498669 Although lipofection induced can *activate* [nuclear factor kappaB (NF-kappaB)] , which , in turn , increases the transgene expression from plasmid DNA in which any NF-kappaB responsive element is incorporated , no attempts have been made to use such biological responses as NF-kappaB activation against a vector to enhance vector mediated gene transfer . Positive_regulation NFKB1 TNF 16042757 1459694 Taken together , our data suggest that both the secretion of VEGF from glioma cells and activation of [NFkappaB] in endothelial cells *induced* by are necessary for endothelial cell survival as they increase the expression of antiapoptotic genes in endothelial cells under conditions of serum starvation . Positive_regulation NFKB1 TNF 16043718 1441898 *induced* [NF-kappaB] and p38 kinase activities and clinical symptoms of collagen induced arthritis in mice were all diminished . Positive_regulation NFKB1 TNF 16051251 1525203 Therefore , we investigated the effect of statins on *induced* [NF-kappaB] signaling in human endothelial cells ( EC ) . Positive_regulation NFKB1 TNF 16051251 1525205 Statin-treatment prevented *induced* [NF-kappaB] binding activity , nuclear translocation of the NF-kappaB p65 subunit , as well as NF-kappaB controlled tissue factor ( TF ) gene transcription in cultured EC . Positive_regulation NFKB1 TNF 16051251 1525216 These studies demonstrate that *induced* [NF-kappaB] activation is abrogated by statin treatment in HUVEC independently of the classical IKK-pathway but via inhibition of PI3-kinase/Akt signaling . Positive_regulation NFKB1 TNF 16055086 1442052 The nuclear translocation of p50/p50 complex due to M. leprae treatment correlated with repression of [NF-kappaB-driven] transcription *induced* by . Positive_regulation NFKB1 TNF 16080915 1442775 Comparative gene array analysis of *induced* MAPK and [NF-kappaB] signaling pathways between retinal ganglion cells and glial cells . Positive_regulation NFKB1 TNF 16081638 1466259 is a potent *activator* of [NF-kappaB] , and levels of this cytokine are increased within the myometrium at term . Positive_regulation NFKB1 TNF 16084531 1481903 The interference with the TNFalpha pathway is reflected by reduced NFkappaB activation in anti-oxidants treated cells but the compounds are not able to contrast *mediated* activation of [NFkappaB] . Positive_regulation NFKB1 TNF 16105982 1482163 Exogenous *enhanced* [NF-kappaB] nuclear translocation in MDS BMMCs above baseline levels . Positive_regulation NFKB1 TNF 16107322 1496319 The herb treatment suppressed LPS stimulated TNFalpha release in vivo and by cultured KC. Direct addition of the aqueous herb extract suppressed [NF-kappaB] *activation* by KC and promoter activity in RAW cells under LPS stimulation . Positive_regulation NFKB1 TNF 16116965 1449130 1 h , 2 h , 4 h and 6 h after LPS injection , the *activation* of [NF-kappaB] in blood mononuclear cells and the content of and IL-6 in plasma was detected by enzyme linked immunoadsordent assay ( ELISA ) . Positive_regulation NFKB1 TNF 16117790 1449207 RXM partially suppressed p38 phosphorylation and [NFkappaB-driven] luciferase activity *induced* by and IFNgamma . Positive_regulation NFKB1 TNF 16122789 1546735 Treatment of cells with BAY 11-7082 at 50 microM significantly inhibited basal , LPS- and *induced* [NF-kappaB] and COX-2 expression , and IL-6 and PGF2alpha release . Positive_regulation NFKB1 TNF 16123045 1467036 In vivo , *induced* [NF-kappaB] as determined by whole mouse body bioluminescence . Positive_regulation NFKB1 TNF 16123700 1449418 The result of EMSA showed that capsaicin inhibited *induced* [nuclear factor-kappa B (NF-kappaB)] activation in PF-10 cell cultures . Positive_regulation NFKB1 TNF 16129813 1450022 The *induced* increase in [nuclear factor (NF)-kappaB] DNA binding activity was significantly suppressed by TDZD-8 . Positive_regulation NFKB1 TNF 16129813 1450029 GSK-3 regulates induced IkappaB-alpha degradation and [NF-kappaB] *activation* independent of IkappaB-kinase-beta and subsequent induction of TF and VCAM-1 expression in human endothelial cells . Positive_regulation NFKB1 TNF 16132362 1450154 In human colon epithelial cells , the effect of quercetin on *induced* [nuclear factor kappa B (NFkappaB)] activation was examined . Positive_regulation NFKB1 TNF 16132362 1450156 Furthermore , quercetin dose-dependently inhibited an inflammatory signal *dependent* [NFkappaB] activation . Positive_regulation NFKB1 TNF 16132362 1450158 Our data suggest that rutin acted as a quercetin deliverer to the large intestine and its anti-inflammatory action in TNBS induced colitis rats may be through quercetin mediated inhibition of *induced* [NFkappaB] activation . Positive_regulation NFKB1 TNF 16135789 1450385 Reconstitution of RelA-deficient murine embryonic fibroblasts with RelA S276A or RelA S536A decreased *induced* acetylation of lysine 310 and expression of the endogenous [NF-kappaB-responsive] E-selectin gene . Positive_regulation NFKB1 TNF 16140265 1454786 We also found that SM-7368 strongly inhibits *induced* [NF-kappaB] activity but not AP-1 activity . Positive_regulation NFKB1 TNF 16141211 1467204 Differences in induced STAT3/DNA binding activity and not [NFkappaB] and AP-1 transcriptional *activation* correlated with impaired collagen accumulation/TIMP-1 induction in TNFR2 ( -/- ) cells . Positive_regulation NFKB1 TNF 16143316 1454924 Parallel with inhibitory effect on cell growth , HCA dose dependency inhibited *induced* activation of [NF-kappaB] accompanied with inhibition of the translocation of p50 . Positive_regulation NFKB1 TNF 16144315 1451528 To investigate the regulatory effects of various anti-inflammatory drugs on both endogenous and *induced* [NF-kappaB] activation as well as the relative biological activity . Positive_regulation NFKB1 TNF 16144315 1451530 L ( -1 ) ) can decrease both endogenous and induced [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 16144315 1451532 However , its influence on *induced* [NF-kappaB] activation is needed for further study . Positive_regulation NFKB1 TNF 16162672 1461508 Transfection experiments indicated that OspG can prevent phospho-IkappaBalpha degradation and [NF-kappaB] activation *induced* by stimulation . Positive_regulation NFKB1 TNF 16164629 1456326 A20 , but not A1 , inhibited *induced* [NF-kappaB] activation by preventing IkappaBalpha degradation , hence subsequent up-regulation of the proinflammatory molecules ICAM-1 and MCP-1 . Positive_regulation NFKB1 TNF 16181613 1468113 Honokiol inhibits *stimulated* [NF-kappaB] activation and NF-kappaB regulated gene expression through suppression of IKK activation . Positive_regulation NFKB1 TNF 16181613 1468115 We observed that the *induced* [NF-kappaB] activation was blocked by honokiol in four different cancer cell lines as evidenced by EMSA . Positive_regulation NFKB1 TNF 16186825 1468299 TAK1-deficient cells failed to activate transcription factor [NF-kappaB] and mitogen activated protein kinases in *response* to interleukin 1beta , and Toll-like receptor ligands . Positive_regulation NFKB1 TNF 16191192 1468316 In *response* to , latent cytoplasmic [NF-kappaB] is activated , enters the nucleus , and induces expression of inflammatory and anti-apoptotic gene expression programs . Positive_regulation NFKB1 TNF 16192349 1468335 In the absence of RelA phosphorylation on serine-276 , stimulation *leads* to a strong increase in the expression of endogenous [NF-kappaB-responsive] genes , such as Bcl-xL , whose transcriptional up-regulation is mainly controlled by RelB . Positive_regulation NFKB1 TNF 16203735 1483200 Reducing Monarch-1 expression with small interference RNA in myeloid/monocytic cells caused a dramatic increase in [NFkappaB] activation and cytokine expression in *response* to TLR2/TLR4 agonists , , or M. tuberculosis infection , suggesting that Monarch-1 is a negative regulator of inflammation . Positive_regulation NFKB1 TNF 16206033 1464146 Furthermore , the two phthalides exhibited significant suppressive effects on mediated [nuclear factor-kappaB (NF-kappaB)] *activation* in reporter gene assays . Positive_regulation NFKB1 TNF 16210331 1468664 ( ii ) isometric contraction and ( iii ) *induced* nuclear translocation of the pro-inflammatory transcription factor [nuclear factor-kappaB (NF-kappaB)] . Positive_regulation NFKB1 TNF 16210331 1468666 Second , the two drugs block the *induced* nuclear translocation of the pro-inflammatory transcription factor [NF-kappaB] . Positive_regulation NFKB1 TNF 16211219 1464522 [NF-kappaB] was *activated* by ; Positive_regulation NFKB1 TNF 16223606 1469369 The stimulation of neutrophil-like differentiated HL60 cells with *induced* activation of [NFkappaB] and c-Src kinase , and the activation was attenuated by treatment with the anti-oxidants . Positive_regulation NFKB1 TNF 16233921 1508277 The results from the systems showed that all the three mAbs could neutralize TNF mediated cytotoxicity in L929 cells , *induced* [NF-kappaB] activation in ECV304 cells , and TNF upregulated ICAM-1 surface expression on ECV304 cells in dose dependent manners . Positive_regulation NFKB1 TNF 16242240 1501684 Neurotrophic factors increase *induced* nuclear translocation of [NF-kappaB] in rat PC12 cells . Positive_regulation NFKB1 TNF 16242240 1501691 These results suggested that there is a close correlation between the signaling pathways via TNF receptors and neurotrophin receptors for the NF-kappaB activation , and that NGF and BDNF enhance *induced* nuclear translocation of [NF-kappaB] . Positive_regulation NFKB1 TNF 16246929 1471536 [NF-kappaB] *activation* in human dental pulp stem cells by and LPS . Positive_regulation NFKB1 TNF 16246929 1471538 Because the dental pulp is frequently infected by oral bacteria due to dental decay , in this study , we examined whether lipopolysaccharide (LPS) and *activated* the immunologic transcription factor [nuclear factor kappa B (NF-kappaB)] in DPSCs . Positive_regulation NFKB1 TNF 16253226 1483787 PGG treatment attenuated *induced* [nuclear factor-kappaB (NF-kappaB)] p65 translocation in human umbilical vein endothelial cells . Positive_regulation NFKB1 TNF 16260783 1490025 Receptor interacting protein ( RIP ) plays a critical role in induced IkappaB kinase (IKK) activation and subsequent *activation* of transcription factor [NF-kappaB] . Positive_regulation NFKB1 TNF 16260783 1490027 However , the molecular mechanism by which RIP mediates *induced* [NF-kappaB] activation is not completely defined . Positive_regulation NFKB1 TNF 16260783 1490029 Moreover , a forced recruitment of TAK1 to TNF-R1 in the absence of RIP is sufficient to mediate *induced* [NF-kappaB] activation , indicating that the major function of RIP is to recruit its downstream kinases to the TNF-R1 complex . Positive_regulation NFKB1 TNF 16269157 1525811 AR treatment attenuated *induced* [NF-kappaB] p65 translocation in HUVECs in a dose dependent manner . Positive_regulation NFKB1 TNF 16271513 1518402 *induced* maximal [NF-kappaB] translocation in these T cells , indicating that they remain receptive to alternative signaling pathways , and pulsing with IL-12 prior to TCR triggering reversed their apparent anergy . Positive_regulation NFKB1 TNF 16271621 1479242 Moreover , we found that depletion of GSH would also attenuate the TNF-alpha induced VCAM-1 expression with a down-regulation of the *induced* [NF-kappaB] activation and without significant effect on AP-1 . Positive_regulation NFKB1 TNF 16271738 1502444 Furthermore , CKS significantly inhibited the induced production of intracellular reactive oxygen species ( ROS ) and *activation* of [NF-kappaB] by preventing IkappaB degradation and inhibiting IkappaB kinase activity . Positive_regulation NFKB1 TNF 16275389 1480104 IL-17 suppressed *induced* CCL27 secretion and mRNA expression and [NF-kappaB] activity in keratinocytes . Positive_regulation NFKB1 TNF 16276095 1502478 Only the full-length bovine FLIP protein could inhibit NF-kappaB activation induced by LPS , whereas the death effector domain region alone was able to inhibit *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 16288471 1509672 *stimulated* translocation of [NF-kappaB] into the nucleus and degradation of IkappaB-alpha was blocked by helenalin , but not by U0126 , SB202190 , or SP600125 . Positive_regulation NFKB1 TNF 16288994 1484465 These results suggest that the inhibitory effect of equol on TNF-alpha expression is mediated , at least in part , by blocking [NF-kappaB] activation and the inhibition of expression by equol might be *involved* in its osteoprotective effect . Positive_regulation NFKB1 TNF 16289876 1502642 A gel shift assay further showed that *induced* [Nuclear Factor-kappaB (NF-kappaB)] activity was significantly reduced by cryptotanshinone . Positive_regulation NFKB1 TNF 16294327 1532385 Curcumin inhibited interleukin-1beta- and *induced* activation of activator protein-1 (AP-1) and mitogen activated protein ( MAP ) kinases ( ERK , c-Jun N-terminal kinase (JNK) , and p38 MAP kinase ) , but not of [nuclear factor-kappaB (NF-kappaB)] . Positive_regulation NFKB1 TNF 16301661 1485239 Lung [NF-kappaB] activation and neutrophil recruitment *require* IL-1 and receptor signaling during pneumococcal pneumonia . Positive_regulation NFKB1 TNF 16303143 1546889 Further , stimulation induced the degradation of IkappaB-alpha and *resulted* in the transcriptional activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 16304386 1485551 A key role is played by the presence of constitutive [nuclear factor (NF)-kappaB] , which is *induced* by LMP1 , as well as by CD30 , CD40 , , and Notch1 interactions , and results in the upregulation of at least 45 genes including chemokines , cytokines , receptors , apoptotic regulators , intracellular signaling molecules , and transcription factors . Positive_regulation NFKB1 TNF 16318585 1487688 Further , NF-kappaB and Stat1 proteins directly regulate transcription by interacting cooperatively on [NF-kappaB-SIE] DNA binding in *response* to plus IFN-gamma . Positive_regulation NFKB1 TNF 16318585 1487698 In contrast , IFN-gamma inhibits *induced* transcription of an [NF-kappaB] reporter gene in a Stat1 dependent mechanism in 2fTGH fibroblasts . Positive_regulation NFKB1 TNF 16321974 1511607 We undertook an iterative computational and experimental investigation of the dynamic properties of *mediated* activation of the transcription factor [NF-kappaB] . Positive_regulation NFKB1 TNF 16323294 1488056 Luciferase reporter gene assays further demonstrated that sKLK inhibited both basal and *stimulated* [NFkappaB] activation . Positive_regulation NFKB1 TNF 16331273 1533102 Diosgenin suppressed *induced* [NF-kappaB] activation as determined by DNA binding , activation of IkappaBalpha kinase , IkappaBalpha phosphorylation , IkappaBalpha degradation , p65 phosphorylation , and p65 nuclear translocation through inhibition of Akt activation . Positive_regulation NFKB1 TNF 16331685 1512040 In this report we provide evidences that oleandrin , a cardiac glycoside potentially inhibited IL-8- , formyl peptide ( FMLP ) - , EGF- , or nerve growth factor (NGF)- , but not IL-1- or *induced* [NF-kappaB] activation in macrophages . Positive_regulation NFKB1 TNF 16338138 1526337 Enone analogues of curcumin were compared with curcumin for their abilities to inhibit the *induced* activation of [NFkappaB] , using the Panomics ' NFkappaB Reporter Stable Cell Line . Positive_regulation NFKB1 TNF 16338458 1503942 Induction of the inhibitor may involve *stimulated* activation of [NFkappaB] . Positive_regulation NFKB1 TNF 16339837 1539631 In contrast , Nrf2 did not inhibit *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 16352630 1504292 We have previously reported that tumor necrosis factor receptor associated factor 1 ( TRAF1 ) , an intracellular protein , which binds to a range of molecules , including tumor necrosis factor (TNF) receptor family members , regulates *induced* [NF-kappaB] and AP-1 signaling as well as TCR triggered proliferative responses in T cells . Positive_regulation NFKB1 TNF 16360644 1512311 Epoxyquinone A monomer ( EqM ) , a synthetic derivative of the natural product epoxyquinol A , has previously been shown to be a potent inhibitor of *induced* activation of [NF-kappaB] , but the mechanism by which EqM inhibits NF-kappaB activation was not known . Positive_regulation NFKB1 TNF 16377638 1526966 Because several of these genes are regulated by NF-kappaB , we postulated that SAHA mediates its effects by modulating NF-kappaB and found that SAHA suppressed [NF-kappaB] activation *induced* by , IL-1beta , okadaic acid , doxorubicin , lipopolysaccharide , H ( 2 ) O ( 2 ) , phorbol myristate acetate , and cigarette smoke ; Positive_regulation NFKB1 TNF 16378960 1505360 We report here that expression of MC160 molecules did significantly reduce mediated [NF-kappaB] *activation* in 293T cells , as measured by gene reporter and gel mobility shift assays . Positive_regulation NFKB1 TNF 16379012 1526995 A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and mediated [NF-kappa B] *activation* . Positive_regulation NFKB1 TNF 16384711 1520059 Neutrophils from healthy volunteers ( NAC naïve ) were pre incubated with NAC for 30 min and the effects on the release of elastase and IL-8 , the respiratory burst in response to fMLP and PMA , on induced [NFkappaB] *activation* and on the migration across an endothelial-epithelial bilayer were investigated . Positive_regulation NFKB1 TNF 16385659 1494173 To determine the functional roles of TNFR1 and TNFR2 on TNF induction , we investigated [NF-kappaB] activation and *induction* after neutralizing TNFR1 and TNFR2 by an antibody treatment . Positive_regulation NFKB1 TNF 16385659 1494179 We found that [NF-kappaB] activation and *induction* are blocked by TNFR1 neutralizing antibody treatments . Positive_regulation NFKB1 TNF 16394182 1533466 Arvanil also prevents induced [nuclear factor-kappaB (NF-kappaB)] *activation* by direct inhibition of IkappaBalpha degradation , NF-kappaB binding to DNA , and NF-kappaB dependent transcription . Positive_regulation NFKB1 TNF 16399623 1513040 Silymarin is a polyphenolic flavonoid derived from milk thistle ( Silybum marianum ) and has anti-inflammatory , cytoprotective as well as anticarcinogenic effects [ Manna , S.K. , Mukhopadlhyay , A. , Van , N.T. , Aggarwal , B. , Silymarin suppresses induced *activation* of [NF-kappaB] , c-Jun N-terminal kinase , and apoptosis . Positive_regulation NFKB1 TNF 16408291 1540225 Furthermore , the proteasome inhibitor MG-132 caused loss of IkappaBalpha , and an increase of it is phosphorylated form , but basal NF-kappaB was unchanged , whilst *activation* of [NF-kappaB] by was completely inhibited , suggesting that MG-132 activity is independent of constitutive NF-kappaB activation . Positive_regulation NFKB1 TNF 16420740 1514809 In contrast , the broad-spectrum tyrosine kinase inhibitor genistein and the MEK-1 inhibitor ( PD98059 ) abrogated GM-CSF priming of release and *activation* of both [NF-kappaB] and AP-1 . Positive_regulation NFKB1 TNF 16424045 1515405 Treatment with 17AAG caused degradation of RIP and IKKbeta that , in turn , blocked *induced* [NF-kappaB] activation and antiapoptotic gene expression . Positive_regulation NFKB1 TNF 16424045 1515407 These results suggest that the cytotoxicity seen with 17AAG and TNF treatment results from blocking *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 16428340 1554356 Using EMSA , we found that *caused* [NF-kappaB] nuclear translocation in VSMCs after 1 h of incubation . Positive_regulation NFKB1 TNF 16428340 1554358 Finally , we demonstrate that the large immunophilin FK-506 binding protein FKBP51 is essential for *induced* [NF-kappaB] activation in VSMCs . Positive_regulation NFKB1 TNF 16432451 1516262 Sodium salicylate inhibits induced [NF-kappaB] *activation* , cell migration , invasion and ICAM-1 expression in human melanoma cells . Positive_regulation NFKB1 TNF 16432451 1516265 The aim of this study was to investigate the effect of the non-steroidal anti-inflammatory agent sodium salicylate on induced *activation* of the transcription factor [nuclear factor-kappaB (NF-kappaB)] and upregulation of intercellular adhesion molecule-1 ( ICAM-1 ) , and TNF-alpha stimulated cell migration and invasion through fibronectin . Positive_regulation NFKB1 TNF 16432451 1516268 Sodium salicylate inhibited *stimulated* [NF-kappaB] activation in melanoma cells in a concentration dependent manner , and this was achieved with pre-incubation times as short as 15 min. TNF-alpha stimulated ICAM-1 expression in HBL cells was also downregulated by sodium salicylate , although in a manner inversely related to the concentration of this agent . Positive_regulation NFKB1 TNF 16432451 1516271 In conclusion , sodium salicylate effectively inhibited *induced* upregulation of [NF-kappaB] , ICAM-1 expression , in-vitro migration and invasion in human melanoma cells , indicating that non-steroidal anti-inflammatory drugs may be a useful therapeutic approach to oppose inflammation induced melanoma invasion and metastasis in vivo . Positive_regulation NFKB1 TNF 16436709 1516541 Furthermore , ACHP inhibited *induced* [NF-kappaB] ( p65 ) recruitment to the HIV-1 LTR , as assessed by chromatin immunoprecipitation assay . Positive_regulation NFKB1 TNF 16439527 1516608 Furthermore , both ectopically expressed SV5 SH and MuV SH blocked *activation* of [NF-kappaB] by in a reporter gene assay , suggesting that both SH proteins can inhibit TNF-alpha signaling . Positive_regulation NFKB1 TNF 16450077 1521976 This signalling cascade is consistently associated with a reduced translocation of *activated* [NF-kappaB] into the cell nucleus . Positive_regulation NFKB1 TNF 16464438 1534594 In order to understand underlying regulatory mechanisms , inhibition of both NF-kappaB-driven reporter gene expression and *induced* binding of [NF-kappaB] to a consensus response element was achieved at concentrations of 320 microM ( flavokavain A ) , 175 microM ( flavokavain B ) and 870 microM ( kavain and dihydrokavain ) . Positive_regulation NFKB1 TNF 16475830 1524169 These results suggest that suppresses apoAI promoter activity through both the MEK/ERK and JNK pathways but is not *mediated* by either p38 MAP kinase activity or [NF-kappaB] activation . Positive_regulation NFKB1 TNF 16484540 1524758 We demonstrated that 3'-hydroxy-flavone but not the chemical core structure flavone blocked *induced* [nuclear factor (NF)-kappaB] transcriptional activity and IP-10 expression at the level of NF-kappaB/IkappaBalpha phosphorylation/degradation by inhibiting IkappaB kinase activity . Positive_regulation NFKB1 TNF 16490171 1528593 Similarly , NAC inhibited the activation of [NF-kB] *induced* by , but had no effect on the activation of NF-kappaB induced by IL-1 . Positive_regulation NFKB1 TNF 16490171 1528597 PDTC significantly inhibited the activation of [NF-kappa B] *induced* by and IL-1 . Positive_regulation NFKB1 TNF 16491481 1548706 *induced* [NF-kappaB] activity was determined by gel shift and reporter gene assays in addition to monitoring IkappaBalpha phosphorylation . Positive_regulation NFKB1 TNF 16492740 1535158 *induces* ABCA1 through [NF-kappaB] in macrophages and in phagocytes ingesting apoptotic cells . Positive_regulation NFKB1 TNF 1649771 162932 Furthermore , induces a set of genes and at least part of this transcriptional activation is *mediated* by [NF kappa B] . Positive_regulation NFKB1 TNF 16520020 1598022 RNA interference against Nore1B attenuates NF-kappaB activation induced by T cell receptor ( TCR ) ligation , but not [NF-kappaB] activation *induced* by or lipoteichoic acid . Positive_regulation NFKB1 TNF 16525037 1561689 ML120B concentration-dependently inhibits *stimulated* [NF-kappaB] signaling via inhibition of IkappaBalpha phosphorylation , degradation , and NF-kappaB translocation into the nucleus . Positive_regulation NFKB1 TNF 16525884 1574382 The inhibition of LPS- and *induced* [NF-kappaB] luciferase activity in macrophages was abolished by MK-886 , a selective PPAR-alpha antagonist . Positive_regulation NFKB1 TNF 1653056 164601 In the present work , we investigated the molecular events leading to [NF-kappa B] *activation* by in a human T cell line ( Jurkat ) and its subclone JCT6 , which presents a deficiency in the PKA transduction pathway . Positive_regulation NFKB1 TNF 1653056 164603 Thus , *induced* [NF-kappa B] activation was found to be mediated by none of the major signal mediating kinases such as protein kinase C ( PKC ) , protein kinase A , or Ca ( 2+ ) -regulated kinases . Positive_regulation NFKB1 TNF 1653056 164605 Furthermore , we found that cytoplasmic acidification facilitated [NF-kappa B] *activation* by both and PKC , by a mechanism that increases NF-kappa B/I kappa B dissociation without affecting the NF-kappa B translocation step . Positive_regulation NFKB1 TNF 16543241 1555495 Previous studies indicate that RIP plays an essential role for *induced* [NF-kappaB] activation , but the molecular mechanism by which RIP mediates TNFalpha signals to activate NF-kappaB is not fully defined . Positive_regulation NFKB1 TNF 16543241 1555497 However , it remains to be determined whether the ubiquitination of RIP is required for induced [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 16543241 1555499 Together , our studies provide the first genetic evidence that the ubiquitination of RIP is required for *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 16549374 1549774 Neither apoptosis nor nuclear translocation of [NF-kappaB] , *induced* in HUVEC by was influenced by 1,25 ( OH ) ( 2 ) D ( 3 ) treatment . Positive_regulation NFKB1 TNF 16562828 1538298 Compound 2 also inhibited *induced* [NF-kappaB] activation at 5 microM through the canonical pathway , but was inactive in the Tet-On-Luc assay , indicating specificity of action , although it interfered with Tet-On-Luc at higher concentrations . Positive_regulation NFKB1 TNF 16567640 1542318 Detailed signaling studies showed that NF-kappaB also contributes to IL-6 production and that *induced* [NF-kappaB] activation is MKK3 dependent . Positive_regulation NFKB1 TNF 16571778 1555992 *increased* [NF-kappaB] expression and its activation , and dexamethasone partially reversed these effects . Positive_regulation NFKB1 TNF 16573520 1582515 Mutation of the amino acid residues Trp24 and Pro41 in the COMM domain of COMMD6 completely abolished the inhibitory effect of COMMD6 on *induced* [NF-kappaB] activation , but this was not accompanied by loss of interaction with COMMD1 , COMMD6 or the NF-kappaB subunit RelA . Positive_regulation NFKB1 TNF 16574777 1562435 These findings support the interpretation that mitochondrial generated ROS is a principal component in TNF-alpha induced effects and that Trx2 blocks *induced* ROS generation and downstream [NF-kappaB] activation and apoptosis . Positive_regulation NFKB1 TNF 16581045 1496466 Signal transduction studies revealed that IL-1beta and stimulation *induced* [NFkappaB] phosphorylation in A549 cells , but antagonist inhibition of NFkappaB p50-p65 phosphorylation correlated with marked reduction of IL-1beta or TNF-alpha induced CCL28 expression . Positive_regulation NFKB1 TNF 16581780 1543836 We recently reported that NS5A protein interacts with TRAF2 and modulates *induced* [NF-kappaB] and Jun N-terminal protein kinase (JNK) . Positive_regulation NFKB1 TNF 16581780 1543838 Since NS5A and NS5B are the essential components of the HCV replication complex , we examined whether NS5B could modulate *induced* [NF-kappaB] and JNK activation . Positive_regulation NFKB1 TNF 16581780 1543840 In this study , we have demonstrated that induced [NF-kappaB] *activation* is inhibited by NS5B protein in HEK293 and hepatic cells . Positive_regulation NFKB1 TNF 16581782 1543860 Further studies suggest that ER stress induces down-regulation of TRAF2 expression , which impairs induced *activation* of [NF-kappaB] and c-Jun N-terminal kinase and turns TNF-alpha from a weak to a powerful apoptosis inducer . Positive_regulation NFKB1 TNF 16584809 1562502 *activates* the degradation of IkappaB-alpha and the nuclear import of cytoplasmic [NF-kappaB] . Positive_regulation NFKB1 TNF 16595893 1544728 Furthermore , electrophoretic mobility shift assay showed that after the cells were incubated with pitavastatin alone or with pitavastatin and TNF-alpha for 24 h , pitavastatin significantly decreased the DNA binding activity of [NF-kappaB] *induced* by . Positive_regulation NFKB1 TNF 16601113 1568701 Overexpression of GSK-3beta did not affect the TNF-alpha induced nuclear translocation of NFkappaB but reduced the nuclear half-life of *induced* [NFkappaB] considerably ( by as much as 9 h ) and enhanced phosphorylation ( by as much as 33 % ) . Positive_regulation NFKB1 TNF 16603398 1550703 The receptor interacting protein kinase 1 ( RIP1 ) is essential for the *activation* of [nuclear factor kappaB (NF-kappaB)] by . Positive_regulation NFKB1 TNF 16603398 1550706 Here , we present evidence that induces the polyubiquitination of RIP1 at Lys-377 and that this polyubiquitination is *required* for the activation of IkappaB kinase (IKK) and [NF-kappaB] . Positive_regulation NFKB1 TNF 16604092 1562644 3. In our NF-kappaB luciferase reporter system , *induced* [NF-kappaB] activation was observed to be reduced by rosmarinic acid . Positive_regulation NFKB1 TNF 16604092 1562648 In accordance with this result , rosmarinic acid also inhibited TNF-alpha induced phosphorylation and degradation of IkappaB-alpha , as well as nuclear translocation of [NF-kappaB] heterodimer *induced* by . Positive_regulation NFKB1 TNF 16604421 1556590 Thalidomide ( 100-800 nM ) concentration-dependently inhibited [NFkappaB] transcriptional activity *induced* by , including IKKalpha expression and IkappaBalpha phosphorylation in HSC-T6 cells . Positive_regulation NFKB1 TNF 16608838 1574928 In this study , we report that [NF-kappaB] *activation* by lipopolysaccharide and plays a pivotal role in the suppression of cyp3a4 through interactions of NF-kappaB with the PXR.retinoid X receptor ( RXR ) complex . Positive_regulation NFKB1 TNF 16611629 1568852 *induced* a quantitatively and temporally equivalent activation of [NF-kappaB] in control and E1A transfected cells . Positive_regulation NFKB1 TNF 16624823 1569381 We found that plumbagin inhibited [NF-kappaB] activation *induced* by , and other carcinogens and inflammatory stimuli ( e.g. phorbol 12-myristate 13-acetate , H2O2 , cigarette smoke condensate , interleukin-1beta , lipopolysaccharide , and okadaic acid ) . Positive_regulation NFKB1 TNF 16626517 1551874 The transcription and expression of the IkappaBalphaM gene , and the inhibitory effect of IkappaBalphaM on *induced* [NF-kappaB] activation in mature DC were detected by polymerase chain reaction ( PCR ) , reverse transcription-polymerase chain reaction ( RT-PCR ) , Western blot analysis , and electrophoretic mobility shift assays , respectively . Positive_regulation NFKB1 TNF 16626517 1551876 Furthermore , AdIkappaBalphaM significantly suppressed the *induced* [NF-kappaB] activation , augmented apoptosis , downregulated CD80 , CD83 , and CD86 surface molecules , IL-12 secretion levels and the ability to stimulate the proliferation of T cells in mature DC . Positive_regulation NFKB1 TNF 16636195 1562943 Metformin also dose-dependently inhibited induced [NF-kappaB] *activation* and TNF-alpha induced IkappaB kinase activity . Positive_regulation NFKB1 TNF 16636588 1583077 [NF-kappaB] was *activated* within 30 min by or interleukin-1beta (IL-1beta) . Positive_regulation NFKB1 TNF 16636588 1583086 *Induction* of [NF-kappaB] within 30 min by and IL-1beta was mediated through intracellular calcium but not ROS . Positive_regulation NFKB1 TNF 16636588 1583090 Silymarin inhibited induced calcium dependent [NF-kappaB] *activation* irrespective of its antioxidant effect . Positive_regulation NFKB1 TNF 16644735 1583265 Mechanistically , our data indicated that , in *response* to , [NFkappaB/p65] phosphorylation and translocation as well as IkappaBalpha phosphorylation and degradation were unchanged , suggesting that Lnk does not modulate NFkappaB activity . Positive_regulation NFKB1 TNF 16645635 1671988 *stimulated* both [NF-kappaB] and c-Jun NH2-terminal kinase (JNK) activities , which had opposite action on cell survival . Positive_regulation NFKB1 TNF 16646083 1563147 Expression of A20 has been shown to protect from TNF induced apoptosis and also functions via a negative-feedback loop to block [NF-kappaB] activation *induced* by and other stimuli . Positive_regulation NFKB1 TNF 16682409 1584045 *induced* [nuclear factor (NF)-kappaB] activation in wild-type but not in NQO1 deleted cells . Positive_regulation NFKB1 TNF 16682409 1584047 The treatment of wild-type cells with dicoumarol , a known inhibitor of NQO1 , also abolished *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 16682409 1584066 We also found that TNF activated NQO1 , and NQO1-specific small interfering RNA abolished the *induced* NQO1 activity and [NF-kappaB] activation . Positive_regulation NFKB1 TNF 16702954 1624669 Surprisingly , activated [NF-kappaB] *induced* mRNA expression in the presence of all DNA damage inducing agents . Positive_regulation NFKB1 TNF 16707445 1564207 conversely , anoikis was partially reversed by [NF-kappaB] activation *induced* either by treatment or by overexpressing the NF-kappaB p65 subunit in HaCaT cells . Positive_regulation NFKB1 TNF 16707469 1564209 Accordingly , *stimulation* of [NF-kappaB] target gene expression by was strongly decreased . Positive_regulation NFKB1 TNF 16714332 1589914 *caused* a progressive increase in [NF-kappaB] activity after 0.5 h and ICAM-1 protein expression two- to threefold of basal after 2 h. Untreated lungs expressed a low and constant level of ICAM-1 between 0 and 3.5 h . TNF-alpha failed to induce NF-kappaB activation and ICAM-1 expression in lungs of NADPH oxidase-deficient mice lacking p47(phox) . Positive_regulation NFKB1 TNF 16723122 1638326 Finally , we critically review the recent data highlighting the role of ROS in [NF-kappaB] *activation* by proinflammatory cytokines ( and IL-1beta ) and lipopolysaccharide (LPS) , two major components of innate immunity . Positive_regulation NFKB1 TNF 16741515 1585356 We demonstrate that [NF-kappaB] DNA binding is *activated* by both UVB and , but discrepancies in the activation of key upstream signaling pathway components such as AKT phosphorylation and IkappaBalpha degradation exist . Positive_regulation NFKB1 TNF 16757480 1599101 Here we show that can *lead* to the induction of [NFkappaB] signaling with a concomitant increase in spermidine/spermine N ( 1 ) -acetyltransferase ( SSAT ) expression in A549 and H157 non-small cell lung cancer cells . Positive_regulation NFKB1 TNF 16771850 1572680 It has been reported that enterocytes produce proinflammatory mediators , including tumour necrosis factor (TNF) and PAF , and we showed that lipopolysaccharide (LPS) and *activate* [nuclear factor (NF)-kappaB] in enterocytes . Positive_regulation NFKB1 TNF 16783201 1573691 Taken together with the *dependent* p38 and [NF-kappaB] activation in primed neutrophil , we conclude that thermal injury induced priming effect of polymorphonuclear neutrophil is TNF-alpha and p38 dependent . Positive_regulation NFKB1 TNF 16784723 1585644 Anti-prostaglandin E2 ( PGE2 ) antiserum or antisense oligonucleotides against PGE2 receptor EP2 or EP3 abrogated inhibitory effects of ketoconazole and terbinafine hydrochloride on *induced* [NF-kappaB] activity and CCL27 , CCL2 , and CCL5 production , indicating the involvement of endogenous PGE2 in the inhibitory effects . Positive_regulation NFKB1 TNF 16784723 1585649 Carboxyheptyl imidazole also suppressed *induced* [NF-kappaB] activity and CCL27 , CCL2 , and CCL5 production . Positive_regulation NFKB1 TNF 16784723 1585654 These results suggest that ketoconazole and terbinafine hydrochloride may suppress *induced* [NF-kappaB] activity and CCL27 , CCL2 , and CCL5 production by increasing PGE2 release from keratinocytes . Positive_regulation NFKB1 TNF 16784892 1599413 Thus , we hypothesized that tumor derived *induces* the activation of [NF-kappaB] and the transcription repressor YY1 , both of which negatively regulate Fas expression and sensitivity to FasL induced apoptosis . Positive_regulation NFKB1 TNF 16785236 1599427 As examined by the DNA binding of NF-kappaB , we found that indirubin suppressed *induced* [NF-kappaB] activation in a dose- and time dependent manner . Positive_regulation NFKB1 TNF 16785236 1599429 [NF-kappaB] reporter activity *induced* by TNFR1 , receptor associated death domain , TRAF2 , TAK1 , NF-kappaB inducing kinase , and IKKbeta was inhibited by indirubin but not that induced by p65 transfection . Positive_regulation NFKB1 TNF 16785565 1577148 Furthermore , in tolerant cells , *induced* [NF-kappaB] p65 phosphorylation was markedly decreased , which was accompanied by the formation of C/EBPbeta-p65 complexes . Positive_regulation NFKB1 TNF 16793775 1599602 Here , we show that the receptor interacting protein ( RIP ) , a key mediator of *induced* [NF-kappaB] and JNK activation , plays a key role in IGF-I receptor signaling . Positive_regulation NFKB1 TNF 16794257 1631651 Quercetin also inhibited *induced* PI 3-kinase activity , Akt phosphorylation , intracellular H ( 2 ) O ( 2 ) production , [NF-kappaB] transactivation , IL-8 promoter activity , and steady-state mRNA levels , consistent with the notion that quercetin inhibits chemokine expression by attenuating NF-kappaB transactivation via a PI 3-kinase/Akt dependent pathway . Positive_regulation NFKB1 TNF 16835238 1606492 Analysis of differentiating epithelia showed that only well differentiated enterocytes activated the 4-kb long MLCK promoter in response to TNF , and consensus promoter reporters demonstrated that *induced* [NFkappaB] activation decreased during differentiation while TNF induced AP-1 activation increased . Positive_regulation NFKB1 TNF 16843665 1613076 Novel curcumin analogs targeting *induced* [NF-kappaB] activation and proliferation in human leukemic KBM-5 cells . Positive_regulation NFKB1 TNF 16843665 1613078 Copper ( II ) conjugates of all synthesized ligands were prepared and structurally characterized as well as evaluated for their potential of inhibiting *induced* [NF-kappaB] activation and proliferation in human leukemic KBM-5 cells wherein compound 13 was found to be more potent than curcumin . Positive_regulation NFKB1 TNF 16863996 1592488 These redox alterations were found to inhibit *induced* IkappaB-alpha phosphorylation and [NF-kappaB] translocation to the nucleus , thus presumably inhibiting expression of genes necessary to inhibit the cytotoxic effects of TNF . Positive_regulation NFKB1 TNF 16865287 1592766 G. lucidum decreased *induced* ( MCF-7 ) as well as constitutive ( MDA-MB-231 ) activity of [NF-kappaB] . Positive_regulation NFKB1 TNF 16865289 1592768 DHMEQ blocked the constitutive DNA binding activity and *mediated* nuclear translocation of [NF-kappaB] in Huh-7 cells . Positive_regulation NFKB1 TNF 16870149 1593091 In addition , our data show that the early expression of does not *lead* to activation of [NF-kappaB] , because disruption of TNF-alpha activity by a neutralizing antibody does not affect nuclear translocation of NF-kappaB , IkappaBalpha degradation or reporter gene activation by apicidin . Positive_regulation NFKB1 TNF 16872805 1672444 Ad.IKKbeta+/- treatment completely inhibited *stimulated* IKK kinase activity , IkappaB alpha degradation and [NFkappaB] DNA binding in addition to completely blocking TNFalpha stimulated ICAM-1 and VCAM-1 expression . Positive_regulation NFKB1 TNF 16873882 1593502 Recently , some important discoveries have underscored the critical role of ROS in TNFalpha signaling , notably in *mediated* activation of [nuclear factor-kappaB (NF-kappaB)] and c-Jun N-terminal kinase ( c-Jun NH2-terminal kinase , JNK ) , as well as in cell death ( apoptotic and necrotic ) pathways . Positive_regulation NFKB1 TNF 16873882 1593504 Here we attempt to review the existing knowledge on the involvement of ROS in death receptor signaling using TNFalpha-TNFR1 as the model system , specifically addressing the involvement of intracellular ROS in *induced* cell death and in TNFalpha induced activation of [NF-kappaB] and JNK and their crosstalk . Positive_regulation NFKB1 TNF 16874302 1600741 Upon *stimulation* of the cells by , [NF-kappaB] and TFIIH are rapidly recruited to the promoter together with additional Mediator and RNAP II , but CDK8 is lost . Positive_regulation NFKB1 TNF 16896803 1601131 High-dose IVIG inhibited induced *activation* of [nuclear factor-kappaB (NF-kappaB)] to a greater degree than dexamethasone in human monocytic U937 cells and human coronary arterial endothelial cells ( HCAEC ) , but not in human T lymphocytic Jurkat cells . Positive_regulation NFKB1 TNF 16904979 1601510 Therefore , we investigated the role of clathrin heavy chain (CHC) in *induced* IKB alpha phosphorylation and [NFKB] activation . Positive_regulation NFKB1 TNF 16916935 1608534 Conversely , GRX1 knockdown sensitizes cells to oxidative inactivation of IKK-beta and dampens *induced* IKK and [NF-kappaB] activation . Positive_regulation NFKB1 TNF 16920299 1666189 CML-1 inhibits *induced* [NF-kappaB] activation and adhesion molecule expression in endothelial cells through inhibition of IkBalpha kinase . Positive_regulation NFKB1 TNF 16924232 1692176 We found that in wild-type mouse embryonic fibroblast (MEF) , *induced* [NF-kappaB] activation as measured by DNA binding but deletion of PKR abolished this activation . Positive_regulation NFKB1 TNF 16928387 1632921 Furthermore , Paeonol reduced induced [NF-kappaB] *transactivation* and IFNgamma induced STAT1 transactivation in CW-2 cells and also in Jurkat cells . Positive_regulation NFKB1 TNF 16931033 1627266 however , the contribution of *mediated* increases in nuclear [NF-kappaB] is uncertain . Positive_regulation NFKB1 TNF 16934229 1627283 Mechanisms of crosstalk between *induced* [NF-kappaB] and JNK activation in hepatocytes . Positive_regulation NFKB1 TNF 16934424 1724325 *upregulates* VCAM-1 and [NF-kappaB] in fibroblasts from nasal polyps . Positive_regulation NFKB1 TNF 16934424 1724329 The activation of [NF-kappaB] *induced* by was determined by electrophoretic mobility shift assays and the influence on the expression of VCAM-1 was investigated . Positive_regulation NFKB1 TNF 16934424 1724331 [NF-kappaB] activity was *enhanced* by stimulation and remarkably suppressed by NF-kappaB proteasome inhibitor . Positive_regulation NFKB1 TNF 16936197 1608941 *Activation* of [NF-kappaB] by 2 , TRAF6 , NF-kappaB inducing kinase , or protein kinase D , which transduce signals downstream of Toll-like receptors , TNF receptors , and free radicals , respectively , were all potent activators of the A20 promoter . Positive_regulation NFKB1 TNF 16939707 1666199 Differential effect of Rhizoma coptidis and its main alkaloid compound berberine on *induced* [NFkappaB] translocation in human keratinocytes . Positive_regulation NFKB1 TNF 16952378 1639504 This study was designed to determine whether N-acetylcysteine (NAC) , an antioxidant , prevents the *activation* of [nuclear factor-kappaB (NF-kappaB)] by exogenously administered in adipocytes , and whether such change affects the production of adipocytokines . Positive_regulation NFKB1 TNF 16952378 1639510 The present study revealed that NAC inhibited the *mediated* activation of [NF-kappaB] and improved the adverse changes in the levels of IL-6 , PAI-1 and adiponectin in 3T3-L1 adipocytes . Positive_regulation NFKB1 TNF 16955245 1611103 After a 4 h recovery period from heat shock , there was inhibition of mediated [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 16973825 1616855 Resveratrol also inhibited *induced* , [NF-kappaB-driven] luciferase expression in rat aortas electroporated with the reporter gene construct . Positive_regulation NFKB1 TNF 16973825 1616857 Thus resveratrol at nutritionally relevant concentrations inhibits *induced* [NF-kappaB] activation and inflammatory gene expression and attenuates monocyte adhesiveness to HCAECs . Positive_regulation NFKB1 TNF 16981138 1617046 We characterized the *induced* binding of [NF kappaB] to this motif . Positive_regulation NFKB1 TNF 16982330 1617120 The apoptotic potential of M8 and RV was compared using a specific double staining method and inhibition of *induced* activation of [NF-kappaB] was studied . Positive_regulation NFKB1 TNF 16987412 1628281 Furthermore , strongly *activated* [nuclear factor-kappa B (NF-kappaB)] as measured by reporter gene assays and by an activity-specific antibody . Positive_regulation NFKB1 TNF 16987412 1628288 mediated activation of IKK-beta *resulted* in activation of [NF-kappaB] and was followed by up-regulation of the bona-fide target gene cyclin D1 . Positive_regulation NFKB1 TNF 17005413 1641121 Coincident with this observation , TSA induced a concentration dependent reduction of constitutive and *induced* [NF-kappaB] activation in Tca8113 cells . Positive_regulation NFKB1 TNF 17005669 1641146 Consistent with this , we further show that an HCMV variant that has lost the ability to downregulate *induced* [NF-kappaB] signaling also fails to downregulate surface expression of TNF receptor 1 , thereby mechanistically linking the inhibition of TNF-alpha induced NF-kappaB signaling by HCMV to TNF receptor targeting . Positive_regulation NFKB1 TNF 17008396 1674096 However , *induced* a p52/RelB [NFkappaB] DNA binding complex in p50 null MEC nuclear extracts . Positive_regulation NFKB1 TNF 17010424 1666323 We investigated the production of and the *activation* of the nuclear transcription factor [NF-kappaB] . Positive_regulation NFKB1 TNF 17011514 1629132 We found that PTEN inhibited [NFkappaB] activation *induced* by . Positive_regulation NFKB1 TNF 17011643 1647598 In transient transfection reporter gene assays , SSAT2 functions as a transcriptional coactivator for NF-kappaB and cooperates with CBP and P/CAF to enhance *induced* [NF-kappaB] activity . Positive_regulation NFKB1 TNF 17012372 1674164 MXF inhibited *stimulated* MAPKs ERK1/2 , 46-kDa JNK , and [NF-kappaB] up to 60 % , 40 % , and 40 % , respectively . Positive_regulation NFKB1 TNF 17015749 1629900 The suppression of induced [NF-kappaB] *activation* by deguelin occurred through the inhibition of the activation of IkappaBalpha kinase , leading to sequential suppression of IkappaBalpha phosphorylation , IkappaBalpha degradation , p65 phosphorylation , p65 nuclear translocation , and NF-kappaB dependent reporter gene expression . Positive_regulation NFKB1 TNF 17016662 1630059 Although not associated with changes in Bcl-2 , Bcl-XL , Bax , Bad or Bak expression levels , we report that the expression of the pro-apoptotic 1-95IGFBP-3 fragment is associated with the inhibition of *induced* [NF-kappaB] activity , similar to that reported for the full length IGFBP-3 protein . Positive_regulation NFKB1 TNF 17018860 1682936 In the resting cell , RhoA suppresses Cdc42 activation , IkappaBalpha degradation , [nuclear factor-kappaB (NF-kappaB)] *activation* , and induction of and NF-kappaB dependent chemokines . Positive_regulation NFKB1 TNF 17018860 1682941 Suppression of TNFalpha induction by RhoA is Rho kinase alpha ( ROCKalpha ) independent , but Cdc42 dependent , because TNFalpha induction by C3 transferase is attenuated by inhibition of Cdc42 , and constitutively active Cdc42 suffices to activate [NF-kappaB] and *induce* . Positive_regulation NFKB1 TNF 17024246 1641546 In contrast , 14.7K did not affect *induced* [NF-kappaB] activation via recruitment of receptor interacting protein 1 (RIP-1) and TNF receptor associated factor 2 ( TRAF-2 ) . Positive_regulation NFKB1 TNF 17028035 1654290 It was concluded that *activates* [NF-kappaB] and AP-1 and induces PGE ( 2 ) release which alters dose-dependently the activity of the pump by activating different EP receptors with different affinities for PGE ( 2 ) . Positive_regulation NFKB1 TNF 17052676 1636332 However , the expression of VCAM-1 on BEAS-2B cells was only up-regulated by *induced* [NF-kappaB] activity . Positive_regulation NFKB1 TNF 17055343 1674848 Since EMMPRIN and MMP-9 up-regulation is associated with activation of the NF-kappaB pathway , we investigated the effect of pioglitazone and resveratrol on *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 17055514 1740136 Mulberry leaf aqueous fractions inhibit induced [nuclear factor kappaB (NF-kappaB)] *activation* and lectin-like oxidized LDL receptor-1 ( LOX-1 ) expression in vascular endothelial cells . Positive_regulation NFKB1 TNF 17055514 1740138 Furthermore , mulberry leaf aqueous fractions inhibited induced *activation* of [nuclear factor-kappaB (NF-kappaB)] and phosphorylation of inhibitory factor of NF-kappaB-alpha ( IkappaB-alpha ) in a time- and concentration dependent fashion . Positive_regulation NFKB1 TNF 1706475 153078 No correlation exists in HL60 cells between [NF-kappa B] *activation* by tumor necrosis factor ( ) and TNF beta and intracellular levels of cyclic AMP . Positive_regulation NFKB1 TNF 1706475 153080 Forskolin or 1-isobutyl-3-methylxanthine drastically increased intracellular levels of cyclic AMP , but neither activated NF-kappa B nor influenced *induced* [NF-kappa B] activation . Positive_regulation NFKB1 TNF 17075836 1649896 RhoA mediated , alpha *induced* activation of [NF-kappaB] in rheumatoid synoviocytes : inhibitory effect of simvastatin . Positive_regulation NFKB1 TNF 17075836 1649899 This study was conducted to examine the role of RhoA in mediating the activation of NF-kappaB in tumor necrosis factor alpha (TNFalpha) stimulated rheumatoid synoviocytes , and to evaluate the modulatory effects of statins on the induced *activation* of RhoA and [NF-kappaB] and the secretion of proinflammatory cytokines by rheumatoid synoviocytes . Positive_regulation NFKB1 TNF 17075836 1649908 This study identifies RhoA as the key regulator of *induced* [NF-kappaB] activation , which ultimately results in the secretion of proinflammatory cytokines in rheumatoid synoviocytes . Positive_regulation NFKB1 TNF 17079781 1708970 Previously we demonstrated that in cultured mouse lung epithelial cells exposed to bolus administration of H ( 2 ) O ( 2 ) , *induced* [NF-kappaB] activity was inhibited , whereas c-Jun-N-terminal kinase (JNK) activation was enhanced via a mechanism involving TNF receptor-1 ( TNF-RI ) . Positive_regulation NFKB1 TNF 17079781 1708985 Nox1 expression and activation inhibited *induced* inhibitor of kappaB kinase (IKK) , and [NF-kappaB] while promoting JNK activation and cell death . Positive_regulation NFKB1 TNF 17085785 1643951 In the present study , we demonstrate that *activates* [NF-kappaB] activity in neuronal , SH-SY5Y , cells and preferentially enhances the binding of p50 and p65 to the promoter/enhancer regions of the MnSOD gene . Positive_regulation NFKB1 TNF 17088249 1675848 Similar to the other ABINs , ABIN-3 binds to A20 and inhibits [NF-kappaB] activation *induced* by , interleukin-1 , and 12-O-tetradecanoylphorbol-13-acetate . Positive_regulation NFKB1 TNF 17108260 1686004 Moreover , IFNgamma failed to affect *induced* IkappaKbeta phosphorylation or IkappaB degradation as well as nuclear [NF-kappaB/DNA] interaction . Positive_regulation NFKB1 TNF 17110197 1645570 One assay analyzes the *induced* translocation of the transcription factor [NF-kappaB] from the cytoplasm into the nucleus 20 min after stimulation with TNFalpha . Positive_regulation NFKB1 TNF 17114179 1677147 Although gamma-tocotrienol completely abolished *induced* [NF-kappaB] activation , a similar dose of gamma-tocopherol had no effect . Positive_regulation NFKB1 TNF 17142966 1653800 stimulation induced the biphasic *increases* in expression of [NFkappaB-p65] , ST3Gal I , FUT IV , ST3Gal IV and ST6GalNAc III mRNAs and the transient increase in expression of ST6Gal I mRNA and the decrease in ST3GalNAc IV mRNA . Positive_regulation NFKB1 TNF 17150968 1694111 In this study we show that the leave extract of WS , as well as its major constituent withaferin A ( WA ) , potently *inhibits* [NFkappaB] activation by preventing the induced activation of IkappaB kinase beta via a thioalkylation-sensitive redox mechanism , whereas other WS-derived steroidal lactones , such as withanolide A and 12-deoxywithastramonolide , are far less effective . Positive_regulation NFKB1 TNF 17160991 1747139 Here we show that ectopic overexpression of catalytically inactive dominant negative PKR expression system suppressed [NF- kappa B] activation *mediated* by TLR3 , TLR9 , , but not by TLR4 . Positive_regulation NFKB1 TNF 17166398 1662000 Furthermore , we found that bFGF inhibits the *mediated* activation of [NF-kappaB] by blocking phosphorylation and degradation of IkappaBalpha . Positive_regulation NFKB1 TNF 17166398 1662004 We also found that bFGF induces hyperphosphorylation of p38 MAPK on endothelial cells , whereas inhibition of such kinase abrogates the effect of bFGF on the *mediated* activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 17178392 1679721 Simvastatin ( 50 micro M ) blocked *induced* [NF-kappaB] transcriptional activity , IkappaB phosphorylation/degradation and DNA binding activity of NF-kappaB . Positive_regulation NFKB1 TNF 17184171 1724568 Consequently , [NF-kappaB] activity and MCP-1 and VCAM-1 *induced* by are suppressed . Positive_regulation NFKB1 TNF 17185631 1717325 fMLP pretreatment also inhibited activation of proinflammatory transcription factor NF-kappaB by TNF-alpha in Caco2bbe cells , reducing *induction* of [NF-kappaB] target genes by both in human intestinal biopsies and Caco2bbe cells . Positive_regulation NFKB1 TNF 17186493 1701649 In addition , KS-Fs and Kur were able to inhibit *induced* [NF-kappaB] activation in 293 cells mediated by the decreased IkappaBalpha phosphorylation . Positive_regulation NFKB1 TNF 17189827 1680093 while *increased* the activities of both [NF-kappaB] and AP-1 . Positive_regulation NFKB1 TNF 17200614 1358587 However , as expected , *induced* [NF-kappaB] activity was stimulated within 10-30 minutes through degradation of IkappaB-alpha . Positive_regulation NFKB1 TNF 17201889 1680697 Tetrandrine ( 0.5-5.0 micromol/L ) concentration-dependently inhibited [NFkappaB] transcriptional activity *induced* by , including IkappaBalpha phosphorylation and mRNA expressions of ICAM-1 in HSC-T6 cells . Positive_regulation NFKB1 TNF 17202332 1680896 Moreover , guanosine abrogated IFN-gamma induced phosphorylation on Ser ( 727 ) and translocation of STAT-1alpha to the nucleus as well as *induced* IkappaBalpha and [NF-kappaB] p65/RelA subunit phosphorylation , thus inhibiting NF-kappaB induced nuclear translocation . Positive_regulation NFKB1 TNF 17207890 1724700 Conversely , TPA inhibited *induced* [NF-kappaB] signaling and was a weak activator of this pathway . Positive_regulation NFKB1 TNF 17207890 1724702 Thus , TPA did not sufficiently activate NF-kappaB to increase transcription through the low affinity NF-kappaB binding sites on RANTES promoter and its inhibitory effect on *induced* [NF-kappaB] signaling resulted in a reduced transcription rate . Positive_regulation NFKB1 TNF 17210691 1681518 The survival mechanism requires [nuclear factor-kappaB (NF-kappaB)] transcription factor activity , which is strongly *induced* by in these cells . Positive_regulation NFKB1 TNF 17240450 1696450 Pre-treatment of magnolol blocked *induced* [NF-kappaB] activation in different cell types as evidenced by EMSA . Positive_regulation NFKB1 TNF 17244613 1710228 Although we have previously demonstrated that NEMO associates with both IKKs , genetic studies reveal that only its interaction with IKKbeta is required for *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 17244613 1710241 Furthermore , exogenously expressed , catalytically inactive IKKbeta blocked TNF- but not IL-1 induced IkappaBalpha degradation in wild-type MEFs , and reconstitution of IKKalpha/beta double knockout cells with IKKalpha rescued IL-1- but not *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 17256146 1725367 These experiments indicate that although both and UVB *stimulate* [NF-kappaB] DNA binding activity in normal human keratinocytes , the mechanisms of NF-kappaB activation by each stimulus is different . Positive_regulation NFKB1 TNF 17260188 1740460 Expression of A20 has been shown to protect from TNF induced apoptosis and also functions via a negative-feedback loop to block [NF-kappaB] activation *induced* by and other stimuli . Positive_regulation NFKB1 TNF 17266397 1725636 The effect of *induced* [NF-kappaB] signaling on Smad signaling and on in vitro osteoblast mineralization was examined using specific NF-kappaB inhibitors and activators , and effects of TNFalpha induced NF-kappaB signaling on BMP-2 induced Runx2 mRNA were examined using RT-PCR . Positive_regulation NFKB1 TNF 17276726 1718323 We found that the overexpression of DGKalpha-WT , but not of DGKalpha-KD , further enhanced the *stimulated* transcriptional activity of an anti-apoptotic factor , [NF-kappaB] . Positive_regulation NFKB1 TNF 17277159 1697886 We found that simvastatin inhibited induced [NF-kappaB] *activation* , and l-mevalonate reversed the suppressive effect , indicating the role of hydroxy-3-methylglutaryl-CoA reductase . Positive_regulation NFKB1 TNF 17307735 1719149 Similarly , we showed by chromatin immunoprecipitation assays as well as by gel-shift assays with nuclear extracts that *induced* [NF-kappaB] binding to regions at positions -380 , -1420 , and -1890 , demonstrated its association with RNA polymerase II and cofactor proteins , and confirmed the functionality of the respective promoter regions in vivo . Positive_regulation NFKB1 TNF 17314097 1719530 Interestingly , peptides spanning CCR2 and/or LZ disrupt IKKgamma-Tax and IKKgamma-PP2A interactions and potently inhibit [NF-kappaB] *activation* by Tax and . Positive_regulation NFKB1 TNF 17314215 1740836 Artesunate also prevented *induced* nuclear [NF-kappaB] translocation , DNA binding activity and gene transcriptional activity , as well as phosphorylation and degradation of IkappaBalpha , but phosphorylation of p38 mitogen activated protein kinase , extracellular signal regulated kinase and c-Jun N-terminal kinase were unaffected . Positive_regulation NFKB1 TNF 17316570 1705699 The results show that Akt contributes to *induced* [NF-kappaB] activation in lung cancer cells through regulating phosphorylation of the p65/RelA subunit of NF-kappaB . Positive_regulation NFKB1 TNF 17316570 1705719 Although individually blocking IKK or Akt partially suppressed *induced* [NF-kappaB] activation , concurrent suppression of these pathways completely inhibited TNF induced NF-kappaB activation and downstream anti-apoptotic gene expression , and synergistically potentiated TNF induced cytotoxicity . Positive_regulation NFKB1 TNF 17321745 1711806 To elucidate the molecular mechanism of inhibition of cell adhesion molecules , we investigated the status of nuclear transcription factor-kappaB ( NF-kappaB ) and were able to establish that compound 8a significantly blocked the *induced* activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 17322278 1747580 *induced* CD38 expression in human airway smooth muscle cells : role of MAP kinases and transcription factors [NF-kappaB] and AP-1 . Positive_regulation NFKB1 TNF 17327432 1706609 These inhibitory effects may be exerted via inhibition of nuclear factor-kappaB (NF-kappaB) activation , as LR-90 suppressed both S100b-and *induced* IkappaB-alpha degradation as well as [NF-kappaB] promoter transcriptional activity . Positive_regulation NFKB1 TNF 17327451 1706620 gAd activated NF-kappaB and enhanced *induced* [NF-kappaB] activity . Positive_regulation NFKB1 TNF 17334236 1707602 We conclude that *induces* upregulation of PTEN expression through [NF-kappaB] activation in human leukemic cells . Positive_regulation NFKB1 TNF 17341614 1665056 For characterization of the cell based assay , activation of the pathway by several agents , for example , tumor necrosis factor alpha (TNF-alpha) , interleukin-1beta (IL-1beta) , lipopolysaccharide (LPS) , camptothecin and phorbol ester ( PMA ) , and the influence of the culture conditions on [NF-kappaB] *activation* by were examined . Positive_regulation NFKB1 TNF 17341614 1665058 [NF-kappaB] was *activated* by , IL-1beta , PMA , and camptothecin in a dose dependent manner , but not by LPS . Positive_regulation NFKB1 TNF 17349210 1708023 Electrophoretic mobility shift assay ( EMSA ) revealed that *induced* [NF-kappaB] transactivation in AML14 cells in a time- and dose dependent fashion , and subsequent supershift assays indicated that the translocated NF-kappaB was the heterodimer p65 ( RelA)/p50 . Positive_regulation NFKB1 TNF 17357478 1665119 NF-kappaB activity induced by TNF-alpha was significantly increased in AM from patients with COPD , and pyrrolidine dithiocarbamate ( PDTC ) and N-acetyl-L-cysteine (NAC) significantly inhibited the activation of [NF-kappaB] *induced* by ( P < 0.05 ) . Positive_regulation NFKB1 TNF 17357832 1783482 The NF-kappaB activity of both cell lines was increased by the addition of TNF-alpha , while *induced* [NF-kappaB] activity was suppressed by prestimulation with GM in a dose dependent manner . Positive_regulation NFKB1 TNF 17357832 1783485 These results indicate that GM inhibits *induced* [NF-kappaB] activation and enhances apoptosis in human pancreatic cancer cell lines . Positive_regulation NFKB1 TNF 17363495 1712925 Both gemcitabine and *activated* [NF-kappaB] in bladder cancer cells and curcumin suppressed this activation . Positive_regulation NFKB1 TNF 17363555 1712970 We now report that cancer associated mutant p53 can augment the induction of [nuclear factor kappaB (NFkappaB)] transcriptional activity in *response* to the cytokine . Positive_regulation NFKB1 TNF 17373813 1720568 The present study examines the effects of selected phytochemicals and apple extracts on *induced* [NF-kappaB] activation in human breast cancer MCF-7 cells . Positive_regulation NFKB1 TNF 17373813 1720570 Apple extracts significantly inhibited the induced [NF-kappaB] *activation* at a dose of 5 mg/mL ( p < 0.05 ) . Positive_regulation NFKB1 TNF 17373813 1720572 Curcumin also significantly blocked the induced [NF-kappaB] *activation* at doses of 10 and 20 microM ( p < 0.05 ) . Positive_regulation NFKB1 TNF 17384033 1715822 Electrophoretic mobility shift assay ( EMSA ) revealed that transient [NF-kappaB] activation in the COX-2 promoter was *triggered* by . Positive_regulation NFKB1 TNF 17387141 1741626 We found that among nine different flavones tested , fisetin was potent in suppressing *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 17390058 1716113 Furthermore , EMSA showed that pitavastatin significantly reduced the DNA binding activity of [NF-kappaB] *induced* by . Positive_regulation NFKB1 TNF 17404114 1721551 We showed by DNA binding assay that [NF-kappaB] activation *induced* by , phorbol 12-myristate 13-acetate , lipopolysaccharide , ceramide , interleukin-1 , and H ( 2 ) O ( 2 ) was suppressed by morin ; Positive_regulation NFKB1 TNF 1740663 182091 [NF-kappa B] binding activity was *inducible* by and phorbol myristate acetate in PLB-985 . Positive_regulation NFKB1 TNF 17434980 1772098 Anandamide dose dependently attenuated the *induced* ICAM-1 and VCAM-1 expression , [NF-kappaB] activation in HCAECs , and the adhesion of monocytes to HCAECs in a CB(1)- and CB(2) dependent manner . Positive_regulation NFKB1 TNF 17439942 1749123 As examined by DNA binding , we found that butein suppressed *induced* [NF-kappaB] activation in a dose- and time dependent manner ; Positive_regulation NFKB1 TNF 17449583 1730011 Quercetin inhibits *induced* [NF-kappaB] transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells . Positive_regulation NFKB1 TNF 17465224 1731905 Inhibition of cancer cell proliferation and suppression of induced *activation* of [NFkappaB] by edible berry juice . Positive_regulation NFKB1 TNF 17465224 1731907 Of the 13 berries tested , juice of 6 significantly inhibited the induced activation of COX-2 expression and *activation* of the nuclear transcription factor [NFkappaB] . Positive_regulation NFKB1 TNF 17467021 1743415 BSO attenuated the *induced* [nuclear factor-kappaB (NF-kappaB)] activation , however , with no detectable effect on AP-1 and its related mitogen activated protein kinases ( MAPKs ) . Positive_regulation NFKB1 TNF 17475277 1744084 In STAT1-deficient mice , [nuclear factor kappaB (NF-kappaB)] *activation* by was attenuated and strongly inhibited by both NAC and L-NMMA . Positive_regulation NFKB1 TNF 17485112 1750541 TSA1 could also inhibit *induced* cytotoxicity on L929 cells and TNF mediated [NF-kappaB] activation on HEK-293T cells . Positive_regulation NFKB1 TNF 17485223 1750545 *Activation* of [NFkappaB] by was also abolished by preincubation of HSC with GSH , but not by deferoxamine , tempol or trolox . Positive_regulation NFKB1 TNF 17496784 1739471 We observed that proteins expressed by Hs294T metastatic melanoma cells are highly acetylated compared with normal melanocytes , and dominant negative PCAF reduced the basal and *stimulated* transcriptional activity of [NF-kappaB] . Positive_regulation NFKB1 TNF 17504796 1783833 The increase in eosinophil [NF-kappaB] binding activity *induced* by GM-CSF and was suppressed by NAC . Positive_regulation NFKB1 TNF 17507688 1772759 IFN-gamma induced CD40 expression involves activation of STAT-1alpha as well as [NF-kappaB] *activation* through an autocrine response to IFN-gamma induced production . Positive_regulation NFKB1 TNF 17516865 1745850 Zyflamend suppressed [NF-kappa B] activation *induced* by both and cigarette smoke condensate . Positive_regulation NFKB1 TNF 1751774 173770 , interleukin 1 , and phorbol myristate acetate are independent *activators* of [NF-kappa B] which differentially activate T cells . Positive_regulation NFKB1 TNF 17522064 1778348 The results indicate that the relative potency for suppression of *induced* [nuclear factor-kappaB (NF-kappaB)] activation was Cur > DMC > BDMC ; Positive_regulation NFKB1 TNF 17522064 1778350 Turmerones also failed to inhibit *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 17523016 1746068 To assess the effects of hyperthermia on TNF-alpha induced up regulation of ECAM and induced *activation* of [NF-kappaB] , we measured ECAM by ELISA , and evaluated the activation of NF-kappaB by Western blotting after TNF-alpha stimulation . Positive_regulation NFKB1 TNF 17523016 1746071 Pretreatment of hyperthermia blocks *induced* [NF-kappaB] activation , resulting in the inhibition of ECAM up regulation in HAEC . Positive_regulation NFKB1 TNF 17533369 1822014 Although DN-IKKbeta inhibited *induced* [NF-kappaB] activity , DN-IKKbeta had no effect on EGF induced NF-kappaB activation , suggesting that EGF induced NF-kappaB activation is IKK independent . Positive_regulation NFKB1 TNF 17537988 1784160 This novel finding supports a model , whereby *dependent* activation of [NF-kappaB] up-regulates phagocyte NADPH oxidase activity , leading to enhanced ROS production and further NF-kappaB activation , potentially contributing to sustained oxidant production in chronic inflammation . Positive_regulation NFKB1 TNF 17541168 1746934 DHT inhibited the [NF-kappaB] activation *induced* by in a manner dependent on the androgen receptor (AR) . Positive_regulation NFKB1 TNF 17550447 1752581 Abnormal nuclear factor (NF)-kappaB signal pathway and aspirin inhibits alpha *induced* [NF-kappaB] activation in keloid fibroblasts . Positive_regulation NFKB1 TNF 17550447 1752583 To examine the effect of aspirin on the *induced* [NF-kappaB] activation in keloid fibroblasts . Positive_regulation NFKB1 TNF 17550447 1752587 In this study , we demonstrate that *induced* [NF-kappaB] activation in keloid fibroblasts , which show more sensitively than the normal skin fibroblasts . Positive_regulation NFKB1 TNF 17550447 1752591 Aspirin pretreatment can inhibit induced *activation* of [NF-kappaB] in a dose dependent manner by preventing the phosphorylation and degradation of IkappaBalpha and nuclear translocation of NF-kappaB . Positive_regulation NFKB1 TNF 17551258 1785782 Exposure to Ang II ( 10 ( -6 ) M for 24 h ) also enhanced intracellular ROS elaboration and the levels of and interleukin (IL)-8 , upregulated chemokine receptor CXCR2 mRNA expression , increased adhesion of endothelial cells to monocytes and *induced* a significant increase in the activity of [nuclear factor (NF)-kappaB] , which was attenuated by pretreatment with the Ang II receptor blocker losartan ( 1 , 3 and 10 muM ) . Positive_regulation NFKB1 TNF 17557931 1815635 We demonstrated using assays of nuclear localization , NF-kappaB subunit phosphorylation , DNA binding , and transcriptional activity that [NF-kappaB] is *activated* by in presheared HUVEC . Positive_regulation NFKB1 TNF 17565651 1753560 *activated* [NF-kappaB] and up-regulated endogenous TFF1 mRNA expression as well as the transcription of the TFF1 reporter genes in a dose dependent manner . Positive_regulation NFKB1 TNF 17567906 1763220 Functionally , transiently overexpressed Zfra sequestered [NF-kappaB] ( p65 ) , WOX1 , p53 and phospho-ERK ( extracellular signal activated kinase ) in the cytoplasm , and or UV light could not effectively *induce* nuclear translocation of these proteins . Positive_regulation NFKB1 TNF 17570221 1753721 RelA/p65 is essential for *induced* [NF-kappaB] activation in adult hepatocytes . Positive_regulation NFKB1 TNF 17592223 1768200 The effects of acute or chronic alcohol exposure were evaluated in human monocytes on the production of or IL-10 production , pro-inflammatory gene and [nuclear factor-kappaB (NF-kappaB)] *activation* . Positive_regulation NFKB1 TNF 17607667 1779775 In cell lines , overexpression of p65 inhibited beta-catenin/TCF4 mediated transcription , while transfection of GSK-3beta resulted in repression of *induced* [NF-kappaB] activity . Positive_regulation NFKB1 TNF 17617381 1769542 Methylglyoxal suppresses *induced* [NF-kappaB] activation by inhibiting NF-kappaB DNA binding . Positive_regulation NFKB1 TNF 17617381 1769544 In this study , we show that methylglyoxal inhibits *induced* [NF-kappaB] activation and NF-kappaB dependent reporter gene expression by inhibiting the DNA binding capacity of NF-kappaB p65 . Positive_regulation NFKB1 TNF 17624386 1775069 The synthetic glucocorticoid , dexamethasone ( DEX ) blunted *stimulated* [NF-kappaB] activation in L6 cells . Positive_regulation NFKB1 TNF 17626094 1787403 Additionally , normal cellular TNF-alpha signaling , measured by quantitation of *induced* stimulation of transcription from an NF-kappaB-responsive reporter plasmid or [NF-kappaB] protein nuclear translocation , was blocked in DV-infected MDM and Huh7 cells . Positive_regulation NFKB1 TNF 17639074 1829603 Presently , we show that hBVR increases PKC-zeta autophosphorylation , stimulation by , as well as cytokine *stimulation* of [NF-kappaB] DNA binding and promoter activity . Positive_regulation NFKB1 TNF 17640567 1771199 We found that mediated [NF-kappaB] *activation* was inhibited by curcumin ; Positive_regulation NFKB1 TNF 17641059 1771326 Indeed we found that induced [NF-kappaB] *activation* was abrogated in MKK4 gene deleted cells , as determined by DNA binding . Positive_regulation NFKB1 TNF 17641670 1798791 Antipsoriatic effects of avarol-3'-thiosalicylate are mediated by inhibition of generation and [NF-kappaB] *activation* in mouse skin . Positive_regulation NFKB1 TNF 17660390 1799071 *induced* [NF-kappaB] and RhoA activation and upregulation of adhesion molecules ICAM-1 and VCAM-1 , increased expression of monocyte chemoattractant protein , enhanced transendothelial migration of monocytes , and augmented monocyte-endothelial adhesion . Positive_regulation NFKB1 TNF 17667842 1805298 Stimulation of TA cells by *increased* the activation of [NF-kappaB] , which was suppressed by the addition of AZM . Positive_regulation NFKB1 TNF 17671727 1777153 Aqueous extract of Magnolia officinalis mediates proliferative capacity , p21WAF1 expression and *induced* [NF-kappaB] activity in human urinary bladder cancer 5637 cells ; Positive_regulation NFKB1 TNF 17671727 1777155 Furthermore , the transactivation of *stimulated* [NF-kappaB] was inhibited by SB203580 treatment . Positive_regulation NFKB1 TNF 17678632 1781206 TMMC inhibited *induced* [nuclear factor kappaB (NF-kappaB)] activation directly and indirectly . Positive_regulation NFKB1 TNF 17683071 1800338 Overexpression of hBVR enhanced both the basal and *mediated* activation of [NF-kappaB] and also that of the NF-kappaB activated iNOS gene . Positive_regulation NFKB1 TNF 17690092 1800487 Here we demonstrate in the same system that GSH depletion down-regulates *induced* [NF-kappaB] transactivation via two mechanisms , depending on the extent of the depletion . Positive_regulation NFKB1 TNF 17690092 1800500 With moderate GSH depletion ( approximately 50 % ) , the down-regulation is IkappaB kinase (IKK) independent and likely acts on NF-kappaB transcriptional activity because *induced* IKK activation , IkappaBalpha phosphorylation and degradation , NF-kappaB nuclear translocation , [NF-kappaB] DNA binding in vitro , and NF-kappaB subunit RelA ( p65 ) recruitment to kappaB sites of target gene promoters all appear unaltered . Positive_regulation NFKB1 TNF 17690318 1794371 Overexpression of the UCHL1 gene significantly attenuated *induced* [NF-kappaB] activity in vascular cells and increased inhibitor of kappa B-alpha ( IkappaB-alpha ) , possibly through the attenuation of IkappaB-alpha ubiquitination , leading to decreased neointima in the balloon injured artery . Positive_regulation NFKB1 TNF 17696945 1782212 Additionally , diverse biologic roles of FLASH , including *induced* [NF-kappaB] activation , cell-cycle progression and cell division , have been identified . Positive_regulation NFKB1 TNF 17702576 1782961 Optineurin negatively regulates *induced* [NF-kappaB] activation by competing with NEMO for ubiquitinated RIP . Positive_regulation NFKB1 TNF 17702576 1782974 NEMO was recently found to contain a region that preferentially binds Lys ( K ) 63-linked but not K48 linked polyubiquitin ( polyUb ) chains , and the ability of NEMO to bind to K63 linked polyUb RIP ( receptor interacting protein ) is necessary for efficient *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 17702576 1782978 Optineurin competitively antagonized NEMO 's binding to polyUb RIP , and its overexpression inhibited *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 17702576 1782982 This competition occurs at physiologic protein levels because microRNA silencing of optineurin resulted in markedly enhanced *induced* [NF-kappaB] activity . Positive_regulation NFKB1 TNF 17763449 1801865 Furthermore , APC directly suppressed the production of and the *activation* of [NF-kappaB] and MAP kinase p38 , and inhibitors of NF-kappaB or p38 reduced the production of MMP-9 , suggesting that APC inhibits MMP-9 by blocking TNF , NF-kappaB , and p38 . Positive_regulation NFKB1 TNF 17766391 1790372 When expressed in human cells , some of the selected molecules , despite their partial degradation , inhibited mediated [NF-kappaB] *activation* while having no effect on the basal activity . Positive_regulation NFKB1 TNF 17784835 1790510 Nuclear localization of [NF-kappaB] in *response* to was evident in differentiated , but not undifferentiated , SNUhES3 cells . Positive_regulation NFKB1 TNF 17786184 1790843 [NFkappaB] *activation* by lipopolysaccharide and was evaluated in tumor cell lines genetically engineered to express luciferase controlled by an NFkappaB-responsive element . Positive_regulation NFKB1 TNF 17827743 1791588 Cornuside treatment attenuated *induced* [nuclear factor-kappa B (NF-kappaB)] p65 translocation in HUVECs . Positive_regulation NFKB1 TNF 17828497 1795613 Our results showed that could *activate* [NF-kappaB] in untransfected cells but not in transfected HSC-T6 cells . Positive_regulation NFKB1 TNF 17855475 1823117 GLNVA also reduced cyclooxygenase (COX)-2 expression , inhibitor of nuclear factor (NF)-kappaB ( IkappaB)alpha/IkappaBbeta degradation , [NF-kappaB] *activation* , and the overproduction of , interleukin (IL)-1beta , and prostaglandin E2 in BV-2 cells . Positive_regulation NFKB1 TNF 17878383 1797041 Activation of [NF-kappaB] , STAT6 , and STAT1 was *induced* in eosinophils by , IL-4 , and IFN-gamma , respectively . Positive_regulation NFKB1 TNF 17878386 1797051 Moreover , and overexpression of p65 *induced* the formation of [NF-kappaB-CARD8] promoter complexes . Positive_regulation NFKB1 TNF 17878386 1797057 Furthermore , in contrast to the full-length protein , CARD8-S did not modify the expression of [NF-kappaB] target genes ( cIAP , A1 ) , in *response* to . Positive_regulation NFKB1 TNF 17879952 1888783 Catalase overexpression impairs *induced* [NF-kappaB] activation and sensitizes MCF-7 cells against TNF-alpha . Positive_regulation NFKB1 TNF 17884817 1818675 By the use of HIF-1-deficient cells and by obliterating NF-kappaB activation , it was determined that the hypoxic TACE response is mediated by HIF-1 signaling , whereas the regulation by also *requires* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 17897950 1823998 However , down-regulation of USP11 dramatically enhances [NF-kappaB] activity in *response* to , indicating that IKKalpha does not require activation of NF-kappaB . Positive_regulation NFKB1 TNF 17897957 1824024 Furthermore , overexpression of a dominant negative mutant of TAK1 blocked the *induced* expression of MMP-9 and activation of [NF-kappaB] and AP-1 . Positive_regulation NFKB1 TNF 17909069 1803589 In addition , Smad7 mediates the inhibitory activity of TGF-beta on *induced* [NF-kappaB] activation and the synergistic activity of TGF-beta on TNF induced apoptosis . Positive_regulation NFKB1 TNF 17927961 1813262 TRAF interacting protein (TRIP) is required for the inhibitory regulation of *induced* [NF-kappaB] signaling via the TNFR/TRAF signaling complexes in vitro . Positive_regulation NFKB1 TNF 17936907 1844359 Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli , but S. aureus fails to both activate [NF-kappaB] in mammary epithelial cells and to quickly *induce* and interleukin-8 ( CXCL8 ) expression in the udder . Positive_regulation NFKB1 TNF 17942934 1814227 In agreement with this , we also found that TNF activated NQO2 , and NQO2-specific small interfering RNA abrogated the induced NQO2 activity and [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 17949817 1844478 It thus activates downstream signaling events to activate transcription factor [NF-kappaB] , and *induce* the expression of IL-1 responsive genes such as and GM-CSF . Positive_regulation NFKB1 TNF 17959522 1814950 Compared to that of the control group , activity of pulmonary [NF-kappaB] in burned rats was markedly increased within 1 PBH and kept increasing till 24 h. Expressions of pulmonary and IL-8 mRNAs *increased* gradually , reaching the peak level at 6 PBH , and PDTC could effectively inhibit pulmonary NF-kappaB activation and expression of the pulmonary cytokines induced by the burn injury . Positive_regulation NFKB1 TNF 17977820 1845470 Phosphorylation of serine 68 in the IkappaB kinase (IKK) binding domain of NEMO interferes with the structure of the IKK complex and *induced* [NF-kappaB] activity . Positive_regulation NFKB1 TNF 17977820 1845472 Furthermore , in complementation experiments of NEMO-deficient murine embryonic fibroblasts , a S68A-NEMO mutant enhanced , whereas a S68E mutant decreased , *induced* [NF-kappaB] activity , thus emphasizing the inhibitory role of the Ser ( 68 ) phosphorylation on the signal induced NF-kappaB activity . Positive_regulation NFKB1 TNF 17989734 1889131 Although tumor necrosis factor (TNF) related apoptosis inducing ligand ( TRAIL ) and both *activate* [NF-kappaB] in human keratinocytes , only TRAIL potently induces apoptosis . Positive_regulation NFKB1 TNF 17999917 1846254 On the other hand , *activated* a transcription factor [NF-kappaB] in OSCC cells , while NBD peptide , an NF-kappaB inhibitor , inhibited the ADAM-17 maturation , thus suggesting that NF-kappaB is involved in ADAM-17 maturation . Positive_regulation NFKB1 TNF 18000166 1860125 OPG promoter functional assays and chromatin immunoprecipitation experiments revealed inhibitory effects of Nutlin-3 on the *induced* [NF-kappaB] DNA binding activity to the OPG promoter . Positive_regulation NFKB1 TNF 18022362 1827534 IAP antagonists induce autoubiquitination of c-IAPs , [NF-kappaB] *activation* , and dependent apoptosis . Positive_regulation NFKB1 TNF 18022363 1827540 Inhibition of NF-kappaB reduced TNFalpha production , and blocking [NF-kappaB] activation or *allowed* tumor cells to survive IAC induced apoptosis . Positive_regulation NFKB1 TNF 18025231 1827745 In a NF-kappaB reporter system , 8K-NBD dose-dependently inhibits *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 18036510 1860857 Therefore , we evaluated the effect six different statins on induced [NF-kappaB] *activation* in human myeloid leukemia cells . Positive_regulation NFKB1 TNF 18036510 1860859 Of the six statins evaluated , only the natural statins ( simvastatin , mevastatin , lovastatin , and pravastatin ) , not the synthetic statins ( fluvastatin and atorvastatin ) , inhibited *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 18040799 1669147 Activation of NF-kappaB by TNF-alpha and inhibition of TNF-alpha induced BDNF expression by Deltap65 ( a dominant negative mutant ) and NEMO binding domain peptide ( an inhibitor of NF-kappaB ) suggests that *induces* BDNF expression through the activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 18040839 1828577 Among the most prominent are the regulation of *induced* [NF-kappaB] activation by adapter proteins such as TRADD and TRAF , and second , the heterogeneity of microglia and their distribution pattern across brain regions . Positive_regulation NFKB1 TNF 18049314 1833195 Oxidized dipyridamole had no effect on mediated [NF kappa B] *activation* . Positive_regulation NFKB1 TNF 18051603 1833260 In addition , streptochlorin inhibited induced [NF-kappaB] *activation* in the newly developed cell based reporter gene assay . Positive_regulation NFKB1 TNF 18056399 1833530 Notably , stimulation of HEK293T cells with or overexpression of the p65 subunit of NF-kappaB *resulted* in up-regulation of NLRP2 and the formation of [NF-kappaB-NLRP2] promoter complexes . Positive_regulation NFKB1 TNF 18062932 1861580 CH3-Avn-c , a synthetically prepared methyl ester derivative of Avn-c with a high biological potency , significantly and dose dependently decreased mRNA expression and secretion of IL-6 , IL-8 , and MCP-1 by HAEC as determined by real-time RT-PCR and ELISA , and it inhibited IL-1beta- and *stimulated* [NF-kappaB] activation as determined by a NF-kappaB DNA binding assay and a NF-kappaB luciferase reporter assay . Positive_regulation NFKB1 TNF 18064709 1937869 It is also suggested that *activates* [NF-kappaB] and increases transgene expression by pDNA having many NF-kappaB binding sites , but TNF-alpha also reduces transgene expression at later time periods , leading to short-term transgene expression . Positive_regulation NFKB1 TNF 18067272 1853686 In a kinase gene screen using a NF-kappaB reporter , we observed that overexpression of casein kinase 1alpha (CK1alpha) enhanced *induced* [NF-kappaB] activation , and a CK1alpha kinase dead mutant , CK1alpha ( K46A ) , reduced NF-kappaB activation induced by TNFalpha . Positive_regulation NFKB1 TNF 18068371 1874489 In this paper , we exhibit that ( i ) HIV-1gene expression was inhibited by lignin , ( ii ) fraction of small molecular mass in HBS lignin ( less than 0.5kDa ) had stronger inhibitory effects than large molecular mass ( more than 1.3kDa ) , ( iii ) lignin also inhibited activation of [NF-kappaB] *induced* by , ( iv ) among six lignin dimer-like compounds , compound 6 containing beta-5 bond has more potent inhibitory activity than compounds 1 , 2 , 3 , 4 and 5 , which contain beta-1 , beta-O-4 , 5-5 , or beta-beta structural units . Positive_regulation NFKB1 TNF 18068998 1853784 Positive and negative signaling components involved in *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 18068998 1853786 Stimulation of cells with *triggers* activation of [NF-kappaB] through various signaling molecules , including TRAF2 , RIP , MAP3K , and the IKK complex . Positive_regulation NFKB1 TNF 18088098 1862379 Both naphthopyrones 1 and 2 completely inhibit *induced* [NF-kappaB] activation at a concentration of 300 microM by inhibiting the enzymatic activity of the kinase IKKbeta . Positive_regulation NFKB1 TNF 18089811 1834826 These findings show that the reduced bystander response in A549 cells is due to *activation* of [NF-kappaB] signaling by , whereas enhanced response to IR-induced bystander signaling in H460 cells was due to release of TRAIL associated with nuclear translocation of PAR-4 . Positive_regulation NFKB1 TNF 18177902 1856273 Avarol inhibited tumor necrosis factor-alpha (TNF-alpha) generation in stimulated human monocytes ( IC ( 50 ) 1 microM ) and induced *activation* of [nuclear factor-kappaB (NF-kappaB)-DNA] binding in keratinocytes . Positive_regulation NFKB1 TNF 18182117 1895184 , found in arthritic joints , *activates* [nuclear factor-kappaB (NF-kappaB)] , whereas retinoic acid receptors (RARs) are activated by retinoid agonists , including all-trans retinoic acid ( atRA ) . Positive_regulation NFKB1 TNF 18182252 1856560 Alpha-lipoic acid inhibits *induced* [NF-kappa B] activation through blocking of MEKK1-MKK4-IKK signaling cascades . Positive_regulation NFKB1 TNF 18184904 1883585 We also found a significant inhibition of *induced* [NF-kappaB] activity by visfatin ( P < 0.001 ) . Positive_regulation NFKB1 TNF 18202703 1876402 Furthermore , *induced* p65/RelA phosphorylation as well as transcriptional activity of [nuclear factor-kappaB (NF-kappaB)] was significantly downregulated in T6 ( -/- ) 3T3 cells . Positive_regulation NFKB1 TNF 18206350 1870562 Expression of non phosphorylated TAK1 interferes with MEKK3 phosphorylation and [NF-kappaB] reporter activity *induced* by transient MEKK3 expression or stimulation . Positive_regulation NFKB1 TNF 18222174 1871079 Some reports have demonstrated that EPA inhibits [NF-kappaB] activation *induced* by or lipopolysaccharide (LPS) in various cells . Positive_regulation NFKB1 TNF 18224289 1839224 TauBr inhibited degradation of IkappaBalpha and *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 18235000 1864348 *induced* the phosphorylation and downregulation of IkappaB-alpha and the translocation of the p65 subunit of [NF-kappaB] to the nucleus . Positive_regulation NFKB1 TNF 18239058 1877019 Furthermore , LY294002 suppressed both IL-1beta- and *induced* [NF-kappaB] activation and IL-1beta- , TNF-alpha- , and IFN-gamma induced activated protein-1 (AP-1) activation . Positive_regulation NFKB1 TNF 18250466 1865281 In this study , the effect of Lactobacillus plantarum lipoteichoic acid ( pLTA ) on LPS induced MAPK activation , [NF-kappaB] *activation* , and the expression of and IL-1R associated kinase M (IRAK-M) was examined . Positive_regulation NFKB1 TNF 18255343 1877299 Treatment of endothelial cells with DHEAS dramatically inhibited the *induced* activation of [NF-kappaB] , an inflammatory transcription factor , and increased protein levels of the NF-kappaB inhibitor , IkappaB-alpha . Positive_regulation NFKB1 TNF 18258304 1884804 When analyzing *induced* [NF-kappaB] activity via luciferase-reporter assays or via EMSA , we were able to show that the dominant negative version of Rac could completely abrogate TNF induced NF-kappaB activity . Positive_regulation NFKB1 TNF 18258304 1884806 In addition , we also observed that inhibition of the ERK pathway led to a reduction in *induced* [NF-kappaB] transcriptional activity ; Positive_regulation NFKB1 TNF 18275839 1937986 induced [NF-kappaB] *activation* and cell oxidant production are modulated by hexameric procyanidins in Caco-2 cells . Positive_regulation NFKB1 TNF 18275839 1937988 Hexameric procyanidins inhibit induced [NF-kappaB] *activation* in Caco-2 cells . Positive_regulation NFKB1 TNF 18275839 1937990 We investigated the capacity of a hexameric procyanidin fraction ( Hex ) to prevent *induced* [NF-kappaB] activation as related to oxidation and membrane interactions . Positive_regulation NFKB1 TNF 18275839 1937992 In Caco-2 cells , Hex ( 2.5-20 microM ) inhibited *induced* [NF-kappaB] activation ( IkappaB phosphorylation and degradation , p50 and RelA nuclear translocation , and NF-kappaB-DNA binding ) , inducible nitric oxide synthase expression , and cell oxidant increase . Positive_regulation NFKB1 TNF 18275839 1937999 In summary , Hex can inhibit NF-kappaB activation by interacting with the plasma membrane of intestinal cells , and through these interactions preferentially inhibits the binding of to its receptor and the subsequent [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 18279557 1944027 EC-M17 dose dependently inhibited *induced* [NF-kappaB] signalling . Positive_regulation NFKB1 TNF 18287053 1872497 Here , we show that the murine CMV M45 protein binds to RIP1 and inhibits induced *activation* of [NF-kappaB] , p38 MAPK , and caspase independent cell death . Positive_regulation NFKB1 TNF 18287248 1896533 We have shown previously that flavopiridol abrogates *induced* [nuclear factor-kappaB (NF-kappaB)] activation . Positive_regulation NFKB1 TNF 18288389 1872685 SC-514 , an inhibitor of IkappaB kinase beta (IKKbeta) , blocked the *induced* activation of [nuclear factor-kappaB (NF-kappaB)] as well as the TNF-alpha promoted metastasis of murine colon adenocarcinoma cells . Positive_regulation NFKB1 TNF 18288389 1872688 M1 was effective in suppressing the induced *activation* of [NF-kappaB] , expression of matrix metalloprotease-9 (MMP-9) , migration and invasion . Positive_regulation NFKB1 TNF 18289527 1878524 Ectodomain shedding of TNF receptor 1 induced by protein synthesis inhibitors regulates mediated *activation* of [NF-kappaB] and caspase-8 . Positive_regulation NFKB1 TNF 18289527 1878527 Nevertheless , we have surprisingly found that CHX , as well as its structural analogue acetoxycycloheximide ( Ac-CHX ) , prevents mediated *activation* of [NF-kappaB] and caspase-8 in human lung carcinoma A549 cells . Positive_regulation NFKB1 TNF 18289527 1878531 Thus , our results indicate that ectodomain shedding of TNF-R1 induced by protein synthesis inhibitors regulates mediated *activation* of [NF-kappaB] and caspase-8 . Positive_regulation NFKB1 TNF 18292192 1911920 , acting through the TNF-R2 , *causes* an early up-regulation of [NF-kappaB] , long lasting induction of the NF-kappaB target gene inhibitor kappaB ( IkappaB ) , and persistent stimulation of other NF-kappaB associated genes including mitogen-inducible gene-6 (MIG-6) , which acts as an IkappaB signaling antagonist , and butyrate induced transcript 1 . Positive_regulation NFKB1 TNF 18295395 1896677 Our results showed that CS inhibited *induced* [NF-kappaB] activation and subsequent vascular cell adhesion molecule 1 and inducible nitric oxide synthase expressions by blocking Akt signals in JB6 cells . Positive_regulation NFKB1 TNF 18309109 1896985 JNK inhibitor and antioxidant also effectively blocked *induced* [NF-kappaB] activation and monolayer permeability in HCAECs . Positive_regulation NFKB1 TNF 18309276 1873749 These extracts also inhibited mRNA expression of and IL-4 , as well as [NF-kappaB] *activation* in RBL-2H3 cells induced by the IgE-antigen complex . Positive_regulation NFKB1 TNF 18313693 1886036 This is sufficient to alter NEMO function , since functional complementation assays using NEMO-deficient pre-B and T lymphocytes show that full-length C417F pathogenic NEMO leads to a partial to strong defect in LPS , IL-1beta and *induced* [NF-kappaB] activation , respectively , as compared to wild type NEMO . Positive_regulation NFKB1 TNF 18314102 1886047 We showed that overexpression of HDAC2 enhanced *induced* [NF-kappaB] activity and that silencing of HDAC2 decreased NF-kappaB activity . Positive_regulation NFKB1 TNF 18331465 1925079 L. reuteri suppressed *induced* [NF-kappaB] activation , including NF-kappaB dependent reporter gene expression in a dose-and time dependent manner . Positive_regulation NFKB1 TNF 18336259 1881559 Since *activates* [NF-kappaB] and AP-1 , we investigated the role of exogenous Nef protein in TNFalpha stimulated U937 cells and primary macrophages . Positive_regulation NFKB1 TNF 18336259 1881562 We observed that exogenous Nef and synergistically *activate* [NF-kappaB] and AP-1 in U937 cells and primary macrophages resulting in enhanced stimulation of the HIV-1 long terminal repeat ( LTR ) , and subsequently in enhanced viral replication in both chronically infected promonocytic U1 cells and acutely HIV-1 infected primary macrophages . Positive_regulation NFKB1 TNF 18336852 1912249 Furthermore , the involvement of NF-kappaB in TNF-alpha induced MMP-9 production was consistent with that *stimulated* degradation of IkappaB-alpha and translocation of [NF-kappaB] into the nucleus which were blocked by helenalin , but not by U0126 and SP600125 , revealed by immunofluorescence staining . Positive_regulation NFKB1 TNF 18357389 1887725 The transactivation of *stimulated* [NF-kappaB] , AP-1 and Sp-1 were inhibited by U0126 and SB203580 treatment . Positive_regulation NFKB1 TNF 18364436 1912776 We , for the first time , demonstrate that binding of staphylococcal enterotoxin B to MHC-II results in activation of TNF-alpha converting enzyme , epidermal growth factor receptor , p38MAPK , and [NF-kappaB] *inducing* biphasic production . Positive_regulation NFKB1 TNF 18385532 1907113 DHMEQ suppressed induced [NF-kappaB] *activation* and partially ameliorated glucose stimulated insulin secretion in a dose dependent manner . Positive_regulation NFKB1 TNF 18386252 1893152 In addition , AGR decreased *induced* activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 18393939 1913455 Finally , when endogenous [NF-kappaB] is *induced* by ( tumour necrosis factor alpha ) treatment , HIF-1alpha levels also change in an NF-kappaB dependent manner . Positive_regulation NFKB1 TNF 18395009 1907235 While the nuclear recruitment of RelA by IRF-2 augments *induced* [NF-kappaB] dependent transcription , the N-terminal truncated mutant form of IRF-2 inhibits the nuclear localization of RelA , and thus interferes with NF-kappaB activation . Positive_regulation NFKB1 TNF 18395009 1907237 Furthermore , the knockdown of IRF-2 by IRF-2 siRNA attenuates *induced* [NF-kappaB] dependent transcription by inhibiting the nuclear localization of RelA . Positive_regulation NFKB1 TNF 18408586 1894019 receptor signaling was *required* for activation of [NF-kappaB] , but not for activation of activating protein 1 family members junD and Fra-1 in day 2 allografts . Positive_regulation NFKB1 TNF 18433717 1915324 *caused* a rapid activation of [NF-kappaB] within 15min as evidenced by gel shift assay ( EMSA ) . Positive_regulation NFKB1 TNF 18434384 1932530 Sevoflurane caused nuclear translocation of SMAD3 and reduced the *induced* nuclear translocation of [NF-kappaB] in primary cultures of proximal tubules from TGF-beta1+/+ but not in TGF-beta1+/- mice . Positive_regulation NFKB1 TNF 18439578 1915601 A further analysis indicated that lycopene attenuated *induced* IkappaB phosphorylation , [NF-kappaB] expression , and NF-kappaB p65 translocation from cytosol to nucleus . Positive_regulation NFKB1 TNF 18439578 1915603 In line with this , *induced* [NF-kappaB-DNA] but not AP1-DNA complexes formation was inhibited by lycopene , as determined by the electrophoretic mobility shift assay ( EMSA ) . Positive_regulation NFKB1 TNF 18439578 1915609 Taken together , we provided here the first evidence showing that lycopene is able to inhibit induced [NF-kappaB] *activation* , ICAM-1 expression , and monocyte-endothelial interaction , suggesting an anti-inflammatory role of lycopene and possibly explaining in part why lycopene can prevent cardiovascular diseases . Positive_regulation NFKB1 TNF 18442799 1900626 The protein synthesis inhibitor cycloheximide ( CHX ) and its structural derivative acetoxycycloheximide ( Ac-CHX ) have been recently shown to block the *induced* activation of [NF-kappaB] via ectodomain shedding of TNF receptor 1 (TNF-R1) in human lung carcinoma A549 cells . Positive_regulation NFKB1 TNF 18442799 1900631 In this study , we show that ERK and p38 MAP kinase are involved in the downregulation of cell surface TNF-R1 upon exposure to Ac-CHX and the subsequent inhibition of induced [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 18442881 1938509 via TNFR1 axis *induces* [NFkappaB] , and may contribute to inflammation facilitated neoplasia . Positive_regulation NFKB1 TNF 18444250 1984037 Betulinic acid suppresses constitutive and *induced* [NF-kappaB] activation and induces apoptosis in human prostate carcinoma PC-3 cells . Positive_regulation NFKB1 TNF 18444250 1984055 BetA also inhibited *induced* activation of [NF-kappaB] via the IkappaBalpha pathway , thereby sensitizing the cells to TNFalpha induced apoptosis . Positive_regulation NFKB1 TNF 18446055 1902765 Finally , pretreatment with pyrrolidine dithiocarbamate ( PDTC ) , an inhibitor of NF-kappaB , reduced TNF-alpha induced ICAM-1 expression and both DPI and RacN17 significantly diminished [NF-kappaB] activation in *response* to . Positive_regulation NFKB1 TNF 18450452 1908443 CARP-2 is an endosome associated ubiquitin ligase for RIP and regulates *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 18450452 1908449 One important consequence of signaling is activation of the transcription factor NF-kappaB , and failure to downregulate *induced* [NF-kappaB] transcriptional activity results in chronic inflammation and death . Positive_regulation NFKB1 TNF 18450452 1908451 We report that CARP-2 , a RING domain containing ubiquitin protein ligase (E3) , is a negative regulator of *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 18450452 1908455 CARP-2 acts at the level of endocytic vesicles to limit the intensity of *induced* [NF-kappaB] activation by the regulated elimination of a necessary signaling component within the receptor complex . Positive_regulation NFKB1 TNF 18455514 1916053 On the other hand , cells preincubated with HMW adiponectin had reduced *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 18463678 1971659 Employing a series of in vitro and in cellulo approaches , we have demonstrated that in primary human keratinocytes ( i ) rapidly *induces* ROS generation , IkappaB degradation , [NF-kappaB] p65 nuclear translocation , and ultimately production of inflammatory cytokines ; Positive_regulation NFKB1 TNF 18463678 1971661 ( iii ) *dependent* [NF-kappaB] activation ( that is , IkappaB degradation and NF-kappaB p65 nuclear translocation ) is not mediated by ROS ; Positive_regulation NFKB1 TNF 18467203 1921435 EMSA showed that IL-1beta and *activated* [NF-kappaB] and AP-1 in MG-63 cells . Positive_regulation NFKB1 TNF 18496506 1965451 The activation of [NF kappaB] and TNF-alpha synthesis *induced* by polymeric IgA or were downregulated by BMP-7 or rosiglitazone . Positive_regulation NFKB1 TNF 18497946 1917526 The expression of CYLD and [NF-kappaB] mRNAs in HSG cells was *increased* by . Positive_regulation NFKB1 TNF 18537100 1923354 HMW adiponectin requires a shorter incubation period to demonstrate inhibition against *induced* [NF-kappaB] activation , compared with gAd . Positive_regulation NFKB1 TNF 18544535 1945803 The changes in TNFR self-association were functionally significant , because pretreating the HeLa cells and 293T cells resulted in increased induced [NF-kappaB] *activation* and TNF induced expression of IkappaB and syndecan-4 mRNA levels . Positive_regulation NFKB1 TNF 18544535 1945805 Although pretreatment with DsbA did not result in an increase in TNF binding to TNFRs , it resulted in increased *induced* activation of [NF-kappaB] , consistent with an allosteric modification of the TNFRs . Positive_regulation NFKB1 TNF 18550065 2010453 Niacin inhibited : ( a ) angiotensin II (ANG II) induced reactive oxygen species ( ROS ) production by 24-86 % , ( b ) low density lipoprotein (LDL) oxidation by 60 % , ( c ) *induced* [NF-kappaB] activation by 46 % , vascular cell adhesion molecule-1 ( VCAM-1 ) by 77-93 % , monocyte chemotactic protein-1 (MCP-1) secretion by 34-124 % , and ( d ) in a functional assay TNF-alpha induced monocyte adhesion to HAEC ( 41-54 % ) . Positive_regulation NFKB1 TNF 18550789 1945940 Conversely , increasing tmTNF-alpha expression by suppressing expression of TNF-alpha converting enzyme that cleaves tmTNF-alpha led to an enhanced activation of NF-kappaB , indicating that tmTNF-alpha , but not , *contributes* to constitutive [NF-kappaB] activation . Positive_regulation NFKB1 TNF 18562480 1946207 The data presented herein suggest a model whereby the TNF R1-IRAK-1 interaction integrates the cellular response to LPS , TNF-alpha , and IL-1 , culminating in a cell poised to activate *dependent* [NF-kappaB] controlled gene expression . Positive_regulation NFKB1 TNF 18563354 1924235 EPS also prevented the *induced* nuclear translocation of [NF-kappaB] , one of the redox-sensitive transcription factors , in a concentration dependent manner . Positive_regulation NFKB1 TNF 18563354 1924237 Taken together , our results suggest that the anti-oxidant components of EPS prevent *induced* [NF-kappaB] activation , chemokine induction , and monocyte adhesion at the site of intestinal inflammation . Positive_regulation NFKB1 TNF 18564176 2010530 We also demonstrated inhibition of *induced* [NF-kappaB] activation in HUVEC treated with glimepiride , which was attenuated by pretreatment with N ( omega ) -nitro-L-arginine methyl ester . Positive_regulation NFKB1 TNF 18565826 1929540 The functional significance of these results was stressed by the stimulation of [NF-kappaB] transcriptional activity , both basal and *stimulated* , induced by an E-cadherin siRNA . Positive_regulation NFKB1 TNF 18566223 1929562 17-AJB effectively inhibited *induced* [NF-kappaB] activation and induced apoptosis of tumor cells . Positive_regulation NFKB1 TNF 18566231 1929574 Pinitol also suppressed the [NF-kappaB] reporter activity *induced* by , TNFR associated death domain , TNFR associated factor-2 , transforming growth factor-beta activated kinase-1 ( TAK-1 ) /TAK1 binding protein-1 , and IkappaBalpha kinase but not that induced by p65 . Positive_regulation NFKB1 TNF 18567808 1929755 As examined by DNA binding , we found that TQ suppressed induced [NF-kappa B] *activation* in a dose- and time dependent manner and inhibited NF-kappaB activation induced by various carcinogens and inflammatory stimuli . Positive_regulation NFKB1 TNF 18569074 1929852 The cellular secretion of TNF-alpha , IL-1beta , IL-6 , NO and IL-10 in supernatant , mRNA expression of , COX-2 , iNOS and HO-1 , protein expression of COX-2 and HO-1 , and *activation* of [NF-kappaB] were assayed by ELISA , the Griess method , real-time quantitative PCR , and Western blot and immunocytochemistry method , respectively . Positive_regulation NFKB1 TNF 18577376 1941005 Indeed , physalin B induced an increase in bioluminescence from DLD-1 4Ub-Luc cells , at concentrations also producing an accumulation of ubiquitinated proteins and inhibiting *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 18577686 1953006 The effective inhibition of *induced* [NF-kappaB] signaling by EF24 extends the therapeutic application of EF24 to other NF-kappaB dependent diseases , including inflammatory diseases such as rheumatoid arthritis . Positive_regulation NFKB1 TNF 18579519 1953051 We recently showed that a novel disulfide reductase , TRP14 , inhibits *induced* [NF-kappaB] activation , and we identified the dynein light chain LC8 , which interacts with the NF-kappaB inhibitor IkappaBalpha , as a potential substrate of TRP14 . Positive_regulation NFKB1 TNF 18579519 1953057 LC8 inhibited *induced* [NF-kappaB] activation in HeLa cells by interacting with IkappaBalpha and thereby preventing its phosphorylation by IkappaB kinase (IKK) , without affecting the activity of IKK itself . Positive_regulation NFKB1 TNF 18582564 1946703 Insulin markedly increased induced [NF-kappaB] *activation* and induced phosphorylated IkappaB-alpha accumulation . Positive_regulation NFKB1 TNF 18591962 1966114 Furthermore , Bcl-x ( L ) downregulation does not affect mediated [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 18593997 1931540 In HNSCC cell lines , 10 ( -8 ) mol/L bortezomib inhibited cell density while inhibiting induced and partially inhibiting basal *activation* of [NF-kappaB1/RELA] , but not NF-kappaB2/RELB . Positive_regulation NFKB1 TNF 18599158 2208606 and ( 3 ) S100B/RAGE induced upregulation of COX-2 , IL-1beta and expression *requires* the concurrent activation of [NF-kappaB] and AP-1 . Positive_regulation NFKB1 TNF 18603781 1941619 cDNA microarray analysis revealed that EPQB decreased *induced* expression of [NF-kappaB] target genes . Positive_regulation NFKB1 TNF 18606397 1984316 SH-5 also blocked [NF-kappaB] activation *induced* by , lipopolysaccharide , phorbol ester , and cigarette smoke but not that activated by hydrogen peroxide and RANK ligand , indicating differential requirement of AKT . Positive_regulation NFKB1 TNF 18612822 2028036 Saccharomyces boulardii blocked tumor necrosis factor-alpha (TNF-alpha) regulation of PPAR-gamma and IL-8 through disruption of mediated [nuclear factor kappa B (NF-kappaB)] *activation* . Positive_regulation NFKB1 TNF 18618239 2086018 We found that transfection of or wild-type TNF-alpha containing LS constitutively *activated* [NF-kappaB] and conferred the cytotoxic resistance of MCF-7 cells , while transfection of a mutant tmTNF-alpha lacking the cytoplasmic segment of LS neither activated NF-kappaB nor affected the sensitivity . Positive_regulation NFKB1 TNF 18618239 2086020 These results indicate that membrane anchored *contributes* to constitutive activation of [NF-kappaB] and resistance to sTNF-alpha induced cell death . Positive_regulation NFKB1 TNF 18621737 1954337 c-IAP1 and c-IAP2 are critical mediators of *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 18621737 1954340 Both c-IAP1 and c-IAP2 have been implicated in *stimulated* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 18621737 1954346 Here we investigate the role of c-IAP1 and c-IAP2 in *stimulated* activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 18621737 1954356 We demonstrate that *induced* [NF-kappaB] activation is severely diminished in the absence of both c-IAP proteins . Positive_regulation NFKB1 TNF 18621737 1954362 Therefore , c-IAP1 and c-IAP2 are required for *stimulated* RIP1 ubiquitination and [NF-kappaB] activation . Positive_regulation NFKB1 TNF 18637177 1942041 We have used this technique to quantitatively characterize *activation* of the transcription factor [NF-kappaB] by the cytokine . Positive_regulation NFKB1 TNF 18644347 1947733 Celecoxib potently inhibits induced nuclear translocation and *activation* of [NF-kappaB] . Positive_regulation NFKB1 TNF 18644347 1947735 Here , we found that Celecoxib potently inhibited *induced* transcriptional activity and DNA binding activity of [NF-kappaB] ; Positive_regulation NFKB1 TNF 18644347 1947746 Taken together , these data indicate that Celecoxib specifically inhibits *induced* [NF-kappaB] activation at the level of its nuclear translocation . Positive_regulation NFKB1 TNF 18650791 1972740 Candesartan suppressed *induced* chemokine expression and [NFkappaB] activation independent of AT1R blockade in cultured renal tubular epithelial cells . Positive_regulation NFKB1 TNF 18662886 1972998 *induced* rapid [NF-kappaB] activation in both HT-29 and FHC cell lines and this effect was differently modulated by NaBt in these two cell lines . Positive_regulation NFKB1 TNF 18662886 1973000 In HT-29 cells , NaBt potentiated [NF-kappaB] activity *induced* by after 4h treatment . Positive_regulation NFKB1 TNF 18662886 1973002 During additional time of TNF-alpha and NaBt co-treatment , NaBt decreased the *mediated* [NF-kappaB] activity in both cell types . Positive_regulation NFKB1 TNF 18676814 1943474 Encoding [NF-kappaB] temporal control in *response* to : distinct roles for the negative regulators IkappaBalpha and A20 . Positive_regulation NFKB1 TNF 18676814 1943478 *induced* [NF-kappaB] activity shows complex temporal regulation whose different phases lead to distinct gene expression programs . Positive_regulation NFKB1 TNF 18683887 2020118 *induced* [NF-kappaB] signaling reverses age related declines in VEGF induction and angiogenic activity in intervertebral disc tissues . Positive_regulation NFKB1 TNF 18687707 2011737 STAT5b knockdown in T84 CEC increased *dependent* [NF-kappaB] and caspase-3 activation . Positive_regulation NFKB1 TNF 18697935 1950327 Both cIAP1 and cIAP2 regulate mediated [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 18697935 1950339 The cellular inhibitor of apoptosis 1 and 2 ( cIAP1 and cIAP2 ) proteins have been implicated in the *activation* of [NF-kappaB] by ; however , genetic deletion of either cIAP1 or 2 did not support a physiologically relevant role , perhaps because of functional redundancy . Positive_regulation NFKB1 TNF 18697935 1950341 Whereas [NF-kappaB] was properly *activated* by in cultured and primary cells deficient in either cIAP1 or 2 , removal of both cIAPs severely blunted its activation . Positive_regulation NFKB1 TNF 18700741 1961356 2Alpha-hydroxyursolic acid is one of the major triterpenoids isolated from apple peels , and its effects on cell proliferation and *induced* [NF-kappaB] activation in MCF-7 cells were examined . Positive_regulation NFKB1 TNF 18700741 1961358 Preincubation with 2alpha-hydroxyursolic acid suppressed *induced* [NF-kappaB] activation in a dose dependent manner and significantly inhibited the activation at a dose of 20 microM of 2alpha-hydroxyursolic acid ( p < 0.05 ) . Positive_regulation NFKB1 TNF 18700741 1961362 These results suggest that 2alpha-hydroxyursolic acid has antiproliferative activities against MCF-7 cells and capabilities inhibiting [NF-kappaB] activation *induced* by partially by suppressing proteasome activities . Positive_regulation NFKB1 TNF 18703532 2011802 Cilostazol also dose-dependently inhibited induced [NF-kappaB] *activation* and TNFalpha induced I kappa B kinase activity . Positive_regulation NFKB1 TNF 18710428 2028209 As for the signalling pathway , stimulation *led* to the phosphorylation of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and p38 mitogen activated protein kinase ( p38MAPK ) and translocation of [nuclear factor kappaB (NF-kappaB)] ( p65 ) into the nuclei . Positive_regulation NFKB1 TNF 18710428 2028239 These data suggest that interaction *leads* to the phosphorylation of Erk1/2 and p38MAPK and nuclear translocation of [NF-kappaB] , which is closely associated with the production and activation of MMP-9 in cultured CC cells of HuCTT-1 and CCKS-1 . Positive_regulation NFKB1 TNF 18712050 1950679 Our data suggest a role for the Ras/mitogen activated protein kinase (MAPK) signaling pathway and the receptor *mediated* activation of [nuclear factor-kappaB (NF-kappaB)] in the etiology of cardiac enlargement in the HHR . Positive_regulation NFKB1 TNF 18719026 1984929 We conclude the inhibitory effects of on GH-inducible promoter activity are *mediated* by [NFkappaB] , especially p65 , by a mechanism that does not require protein synthesis . Positive_regulation NFKB1 TNF 18719121 1955795 In cells from TRADD-deficient mice , *mediated* apoptosis and TNFalpha stimulated [NF-kappaB] , JNK , and ERK activation are defective . Positive_regulation NFKB1 TNF 18753141 1980021 *induced* the maximal S100A6 promoter and transcription factor [NF-kappaB] ( p65 subunit ) . Positive_regulation NFKB1 TNF 18755269 1975307 GbetaL regulates *induced* [NF-kappaB] signaling by directly inhibiting the activation of IkappaB kinase . Positive_regulation NFKB1 TNF 18755269 1975318 Overexpression of GbetaL inhibits *induced* activation of [NF-kappaB] signaling , while down-regulation of GbetaL expression by small interfering RNA enhances NF-kappaB activity . Positive_regulation NFKB1 TNF 18755269 1975320 Taken together , these data suggest that GbetaL is involved in the negative regulation of *stimulated* [NF-kappaB] signaling through a direct interaction with IKK . Positive_regulation NFKB1 TNF 18768892 1957243 Consistently , Nod2-null macrophages tolerant to LPS and MDP showed enhanced production of and IL-6 as well as increased [NF-kappaB] and MAPK *activation* in response to the dipeptide KF1B , the Nod1 agonist . Positive_regulation NFKB1 TNF 18772349 2012051 Further , [NF-kappaB] *activation* by or p65 overexpression stimulates Shh promoter activity and p65 binds to Shh promoter in vivo . Positive_regulation NFKB1 TNF 18779659 1963176 The stimulation of lymphoid cells with , IL-1beta , and LPS *resulted* in significant ROS production and [NF-kappaB] activation . Positive_regulation NFKB1 TNF 18782567 1975927 The electromobility shift assay showed that while Cl1-0 cells exhibited low [NF-kappaB] activity in *response* to , an abundance of basal and TNF-alpha induced NF-kappaB-DNA complex was detected in Cl1-5 cells . Positive_regulation NFKB1 TNF 18819888 1970308 To investigate the effect of rosiglitazone on the expression of [nuclear factor-kappaB (NF-kappaB)] and coupling factor 6 (CF6) *induced* by in cultured human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation NFKB1 TNF 18824032 1987693 , which *activates* [NF-kappaB] , ameliorated alcohol induced cell death in nNOS-/- and wild-type cultures , while an NF-kappaB inhibitor (NFi) blocked the protective effects of TNF-alpha and worsened alcohol induced cell death . Positive_regulation NFKB1 TNF 18830563 2000845 By using a natural stable folate we were able to reverse the EGCG suppression of *induced* [NF-kappaB] activation , the phosphorylation and degradation of IkappaBalpha and the phosphorylation of Akt in this human colon carcinoma cell line . Positive_regulation NFKB1 TNF 18851874 2000873 Although both L153R and C417R impaired TLR and induced [NF-kappaB] *activation* , L153R also increased TNF-alpha induced programmed cell death with decreased A20 expression . Positive_regulation NFKB1 TNF 18930133 2013549 PPM1A and PPM1B act as IKKbeta phosphatases to terminate induced [IKKbeta-NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 18930133 2013569 Furthermore , knockdown of PPM1A and PPM1B expression enhances *induced* IKKbeta phosphorylation , [NF-kappaB] nuclear translocation and NF-kappaB dependent gene expression . Positive_regulation NFKB1 TNF 18930133 2013571 These data suggest that PPM1A and PPM1B play an important role in the termination of mediated [NF-kappaB] *activation* through dephosphorylating and inactivating IKKbeta . Positive_regulation NFKB1 TNF 18948189 2014099 The data showed that , unlike transient oxidative stress , sustained exposure of HLEC to physiologically relevant levels of H ( 2 ) O ( 2 ) ( 50-100 microM for 4 h ) did not induce the degradation of I-kappaB and activation of NF-kappaB , but attenuated *induced* degradation of I-kappaB and activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 18948189 2014101 Consistent with the role of the proteasome in degradation of I-kappaB and activation of NF-kappaB , treatment of HLEC with proteasome inhibitors also attenuated *induced* I-kappaB degradation and [NF-kappaB] activation . Positive_regulation NFKB1 TNF 18948191 1982309 In conclusion , The and IL-6 signals from the blood are necessary for liver regeneration and [NF-kappaB] and STAT3 binding are *activated* via TNF-alpha and IL-6 signal pathways . Positive_regulation NFKB1 TNF 18948845 2053226 Hypertonic saline attenuates *induced* [NF-kappaB] activation in pulmonary epithelial cells . Positive_regulation NFKB1 TNF 18948845 2053228 We hypothesized that HTS would inhibit *induced* [nuclear factor (NF)-kappaB] proinflammatory signaling in pulmonary epithelial cells . Positive_regulation NFKB1 TNF 18948845 2053231 Hypertonic saline significantly reduced *induced* intercellular adhesion molecule 1 levels and [NF-kappaB] nuclear localization . Positive_regulation NFKB1 TNF 18948845 2053248 These results show that HTS inhibits *induced* [NF-kappaB] activation in the pulmonary epithelium and , further , our understanding of its beneficial effects in hemorrhage induced ALI . Positive_regulation NFKB1 TNF 18952128 2021605 The zinc finger containing protein A20 is a negative regulator of *induced* JNK ( c-Jun-N-terminal kinase ) and [NFkappaB] ( nuclear factor kappaB ) signaling . Positive_regulation NFKB1 TNF 18952368 2014714 Sulforaphane suppresses mediated *activation* of [NF-kappaB] and induces apoptosis through activation of reactive oxygen species dependent caspase-3 . Positive_regulation NFKB1 TNF 18952368 2014716 We also report that SFN non-specifically inhibited *induced* [NF-kappaB] activation through the inhibition of IkappaBalpha phosphorylation , IkappaBalpha degradation , and p65 nuclear translocation . Positive_regulation NFKB1 TNF 18952368 2014720 These effects suggest that SFN inhibits *induced* [NF-kappaB] activation through the suppression of IkappaBalpha degradation , leading to reduced expression of NF-kappaB regulated gene products . Positive_regulation NFKB1 TNF 18952368 2014728 In conclusion , the results of the present study indicate that SFN suppresses *induced* [NF-kappaB] activity and induces apoptosis through activation of ROS dependent caspase-3 . Positive_regulation NFKB1 TNF 18974130 1983026 Electrophoretic mobility shift assay showed that pretreatment with picroliv abrogated induced *activation* of [NF-kappaB] . Positive_regulation NFKB1 TNF 18975348 1983211 Inhibition of ROK by specific inhibitors or ROK small interfering RNA suppressed lipopolysaccharide- or *induced* [NF-kappaB] nuclear translocation , DNA binding activity , luciferase reporter gene expression , and IkappaBalpha degradation . Positive_regulation NFKB1 TNF 18981572 1983615 Furthermore , Rb1 inhibited *induced* MAPKs and [NF-kappaB] activation . Positive_regulation NFKB1 TNF 18988888 2015883 Adenovirus mediated overexpression of AdipoR1 and 2 in ECs significantly enhanced the suppressive effect of a subeffective dose of adiponectin on *induced* ICAM-1 expression and [NF-kappaB] activation . Positive_regulation NFKB1 TNF 18990707 2015902 Expression of a PKCdelta-T505A mutant suppressed the thrombin induced but not the *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 18996370 2016018 Inhibition of NF-kappaB activity by short interfering RNA mediated knock-down of p65 impairs , while *activation* of [NF-kappaB] activity by synergizes induction of NF-kappaB target genes by LMX1B . Positive_regulation NFKB1 TNF 19004544 2022202 It has been found that a short cell-permeable peptide spanning the IKK-beta NBD , named NBD peptide , disrupted the association of NEMO with IKKs in vitro and blocked induced [NF-kappaB] *activation* in vivo . Positive_regulation NFKB1 TNF 19019947 2022577 We report here that the nucleocapsid ( N ) protein of HTNV was able to inhibit *induced* activation of [NF-kappaB] , as measured by a reporter assay , and the activation of endogenous p65 , an NF-kappaB subunit . Positive_regulation NFKB1 TNF 19023456 2001484 *induced* activation of [NFkappaB] protects against UV-induced apoptosis specifically in p53-proficient cells . Positive_regulation NFKB1 TNF 19028529 2053486 Treatment with 50 microM of Ser-Ser-Ser and Glu-Glu-Glu , but not Val-Pro-Leu caused an inhibition of induced *activation* of [NF-kappaB] compared to control cells ( P < 0.05 ) . Positive_regulation NFKB1 TNF 19033441 2022956 Functional complementation assays and in vivo pull-down experiments further show that ZF residues involved in ubiquitin binding are functionally important and required for [NF-kappaB] signaling in *response* to . Positive_regulation NFKB1 TNF 1905804 161654 Our results suggest that maximal transcriptional activation of the uPA gene by PMA , IL-1 and *requires* the induction of [NFkB] activity and the decay of a short lived repressor protein , possibly IkB . Positive_regulation NFKB1 TNF 19063961 2030171 [NF-kappaB] DNA binding activity was *increased* by alone but lowered by TNFalpha plus PY . Positive_regulation NFKB1 TNF 19065580 2053577 Furthermore , enniatins A1 and B1 , but not enniatin B were able to inhibit moderately induced [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 19067146 2024084 The TNBS treatment caused colon shortening , increased myeloperoxidase activity , *induced* IL-1beta , , and IL-6 expression in the colon , activated [NF-kappaB] , and potentiated the GAG degrading activities of intestinal microflora . Positive_regulation NFKB1 TNF 19091594 2031042 TRAF6 negatively regulates induced [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 19091594 2031052 Also , induced DNA binding activity and transcriptional *activation* of [nuclear factor kappaB (NF-kappaB)] were also augmented in TRAF6-deficient MEFs . Positive_regulation NFKB1 TNF 19091594 2031057 Moreover , the reintroduction of exogenous TRAF6 into TRAF6-deficient MEFs clearly suppressed induced IKK activation , [NF-kappaB] *activation* and subsequent cytokine expression . Positive_regulation NFKB1 TNF 19091594 2031062 Thus , these data suggest that TRAF6 negatively regulates *induced* [NF-kappaB] activation through its ubiquitin ligase activity . Positive_regulation NFKB1 TNF 19098937 2018726 induced [NF-kappaB] *activation* was determined using a reporter gene assay . Positive_regulation NFKB1 TNF 19098937 2018728 TA-35 ( 1-20 micromol/L ) suppressed *induced* [NF-kappaB] activation in transfected cells ( HEK293/pNiFty-SEAP ) in a dose- ( 1-20 micromol/L ) and time dependent ( 0-48 h ) manner . Positive_regulation NFKB1 TNF 19098937 2018730 Subsequently , both NF-kappaB p65 and its inhibitor IkappaB gradually accumulated in cytoplasmic extracts in a dose- and time dependent manner , indicating the blockage of [NF-kappaB] translocation *induced* by from the cytoplasm to the nucleus . Positive_regulation NFKB1 TNF 19104039 2004119 In models of physiologic [NF-kappaB] pathway *activation* by CARD11 or , compensatory IKKalpha activity was also observed with IKKbeta inhibition . Positive_regulation NFKB1 TNF 19113817 2127668 Cellular stimulation by induced NADPH dependent superoxide production in the endosomal compartment , and this ROS was *required* for IKK mediated activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 19113817 2127676 Inhibiting endocytosis reduced the ability of to *induce* both NADPH dependent endosomal superoxide and [NF-kappaB] , supporting the notion that redox dependent signaling of the receptor occurs in the endosome . Positive_regulation NFKB1 TNF 19131965 2042497 Furthermore , RNF11 was required for A20 to interact with and inactivate RIP1 to inhibit mediated [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 19138739 2037800 ELISA showed that pretreatment with 1alpha,25- ( OH ) ( 2 ) D ( 3 ) significantly inhibited the *induced* [NF-kappaB] activation in HCAEC . Positive_regulation NFKB1 TNF 19144181 2079139 *induced* regulation of Sox9 and [NFkappaB] activity was also U0126 insensitive . Positive_regulation NFKB1 TNF 19147572 2026422 At a dose of 100 micromol/L , EGCG abrogates p300 induced p65 acetylation in vitro and in vivo , increases the level of cytosolic IkappaBalpha , and suppresses induced [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 19148557 2026687 To examine whether estrogen and/or genistein regulate osteoblast differentiation by modulating the NF-kappaB pathway , we examined the effect of 17beta-estradiol and genistein on basal and *stimulated* [NF-kappaB] activity in the preosteoblastic cell line MC3T3 . Positive_regulation NFKB1 TNF 19148557 2026689 Our data reveal that while 17beta-estradiol had no effect on basal NF-kappaB activity in MC3T3 cells , it significantly antagonized [NF-kappaB] activity *induced* by ( 1 or 10 ng/ml ) . Positive_regulation NFKB1 TNF 19148557 2026691 By contrast , genistein ( 10 ( -6 ) or 10 ( -5 ) M ) significantly increased NF-kappaB activity , and showed no antagonistic effects on *induced* [NF-kappaB] promoter activity . Positive_regulation NFKB1 TNF 19148557 2026693 While 17beta-estradiol may stimulate bone anabolism , in part , by antagonizing *induced* [NF-kappaB] activation , genistein not only fails to prevent cytokine induced NF-kappaB activation , but directly promotes NF-kappaB activation in MC3T3 cells . Positive_regulation NFKB1 TNF 19151401 2079187 PolyI : C , flagellin , or also *induced* [NF-kappaB] p65 protein nuclear translocation . Positive_regulation NFKB1 TNF 19152372 2093396 Both S-containing dimeric withanolides , 1 and 2 , completely suppressed induced [NF-kappaB] *activation* when tested at 100 microm . Positive_regulation NFKB1 TNF 19152372 2093398 In addition , this is the first report on the abrogation of *induced* [NF-kappaB] activation for compounds 1 and 2 . Positive_regulation NFKB1 TNF 19158250 2043316 For example , the molluscum contagiosum virus MC160 protein inhibits *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 19158250 2043319 Since cells expressing either the N or C mutant MC160 protein remained similarly resistant to *induced* [NF-kappaB] activation , the N mutant protein probably utilized a different mechanism for inhibiting NF-kappaB . Positive_regulation NFKB1 TNF 19181934 2043845 IL-10 attenuates *induced* [NF kappaB] pathway activation and cardiomyocyte apoptosis . Positive_regulation NFKB1 TNF 19181934 2043864 Inhibition of ERK 1/2 MAPK with PD98059 attenuated the protective role of IL-10 against induced *activation* of IKK and [NF kappaB] as well as cardiomyocyte apoptosis . Positive_regulation NFKB1 TNF 19181934 2043868 IL-10 prevents *induced* [NF kappaB] activation and pro-apoptotic changes in cardiomyocytes by inhibiting IKK phosphorylation through the activation of ERK 1/2 MAPK . Positive_regulation NFKB1 TNF 19183881 2033285 Moreover , ACK significantly suppressed *induced* translocation of redox-sensitive [nuclear factor (NF)-kappaB] as well as degradation of cytosolic I-kappaBalpha . Positive_regulation NFKB1 TNF 19199007 2049723 Phosphorylation on Thr-106 and NO-modification of glyoxalase I suppress the *induced* transcriptional activity of [NF-kappaB] . Positive_regulation NFKB1 TNF 19199007 2049727 Furthermore , we investigated the role of NO-mediated modification and phosphorylation of GLO1 in the *induced* transcriptional activity of [NF-kappaB] . Positive_regulation NFKB1 TNF 19199007 2049729 Suppression of the basal and *induced* [NF-kappaB] activity was significantly stronger upon expression of a GLO1 mutant that was either deficient for the NO-mediated modification or phosphorylation on Thr-106 . Positive_regulation NFKB1 TNF 19199007 2049731 However , upon overexpression of a GLO1 mutant that was deficient for both types of modification , the suppressive effect of GLO1 on *induced* [NF-kappaB] activity was completely abolished . Positive_regulation NFKB1 TNF 19199007 2049735 These findings suggest that phosphorylation and NO-modification of glyoxalase I provides another control mechanism for modulating the basal and *induced* expression of [NF-kappaB-responsive] genes . Positive_regulation NFKB1 TNF 19201747 2033787 Glial activation markers such as macrophage antigen complex-1 ( Mac-1 , OX-42 ) and glial fibrillary acidic protein (GFAP) , production of , interleukin (IL)-1beta , and IL-10 , as well as [nuclear factor-kappa B (NF-kappaB)] *activation* were determined in the lumbar spinal cord . Positive_regulation NFKB1 TNF 19233127 2050547 In addition , chrysin inhibited *induced* activation of [NF-kappaB] in IEC-6 cells . Positive_regulation NFKB1 TNF 19243468 2240656 We report here that HSP70 over-expression in human colon cancer cells can inhibit *induced* [NFkappaB] activation but promote TNFalpha induced activation of c-Jun N-terminal kinase (JNK) through interaction with TNF receptor (TNFR) associated factor 2 ( TRAF2 ) . Positive_regulation NFKB1 TNF 19243468 2240659 Therefore , our study suggests that HSP70 may differentially regulate induced *activation* of [NFkappaB] and JNK through interaction with TRAF2 , contributing to the pro-apoptotic roles of HSP70 in TNFalpha induced apoptosis of human colon cancer cells . Positive_regulation NFKB1 TNF 19249288 2050969 Hydrogen-rich saline treatment decreased the neutrophil infiltration , the lipid membrane peroxidation , [NF-kappaB] *activation* and the pro-inflammatory cytokine interleukin IL-1beta and in the lung tissues compared with those in saline treated rat . Positive_regulation NFKB1 TNF 19255345 2045184 In H9c2 cardiomyocytes , sustained NF-kappaB activation was proapoptotic , an effect dependent on TNFR1 signaling , whereas TNFR2 overexpression attenuated *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 19262565 2062990 Depletion of Set9 by siRNA or mutation of the RelA methylation sites prolongs DNA binding of NF-kappaB and enhances *induced* expression of [NF-kappaB] target genes . Positive_regulation NFKB1 TNF 19265173 2157098 Although these agonists did not induce significant IL-8 gene expression by these cells , they markedly enhanced induced [NF-kappaB] *activation* , resulting in increased IL-8 expression and release . Positive_regulation NFKB1 TNF 19273093 2045771 By employing TNF-alpha / IFN-gamma synergism model which causes beta -cell apoptosis , we found that the antiapoptotic X-linked inhibitor of apoptosis (XIAP) molecule is upregulated by [NF-kappaB] in *response* to and XIAP induction was inhibited by IFN-gamma induced signal transducer and activator of transcription-1 ( STAT1 ) activation , which explains the death of beta -cells by TNF-alpha /IFN-gamma synergism . Positive_regulation NFKB1 TNF 19273239 2045831 *Activation* of [nuclear factor kappa B (NF-kappa B)] by , up-regulates the expression of molecules which are involved in inflammation and cell adhesion . Positive_regulation NFKB1 TNF 19274442 2072832 Pep 3 ( LRENECVS ) which was derived from the hydrophilic region of A1 module in CRD4 remarkably inhibited the binding of TNF-alpha to TNF-R1 , and also reversed *induced* degradation of IkappaB-alpha and nuclear translocation of [NF-kappaB] p65 subunit in HeLa cells . Positive_regulation NFKB1 TNF 19277846 2106026 Sulforaphane had no effect on induced NF-kappaB nuclear binding activity , IkappaB-alpha degradation or *activation* of [NF-kappaB-driven] transcriptional activity . Positive_regulation NFKB1 TNF 19284655 2055712 Moreover , the inhibitory effect of L-norvaline was not reversed by the NOS inhibitor L-NAME and L-norvaline did not interfere with *induced* activation of [NF-kappaB] , JNK , p38mapk , while it inhibited p70s6k ( S6K1 ) activity . Positive_regulation NFKB1 TNF 19284955 2046501 ( 1 microg/L ) strongly *induced* the expression of [NF-kappaB] by approximately 1.76-fold compared with the control in the nuclei of A549 cells , and the induced NF-kappaB expression was significantly suppressed by addition of Feiyanning ( P < 0.01 ) . Positive_regulation NFKB1 TNF 19284955 2046503 Feiyanning Decoction can markedly inhibit human lung cancer A549 cell proliferation , which may be partly due to inhibition of [NF-kappaB] activation *induced* by . Positive_regulation NFKB1 TNF 19289468 2073005 We investigated the physiological role of endogenous MAPK activating death domain containing protein ( MADD ) , a splice variant of the IG20 gene , that can interact with TNFR1 in *induced* activation of [NF-kappaB] , MAPK , ERK1/2 , JNK , and p38 . Positive_regulation NFKB1 TNF 19303852 2052124 Residues of NEMO involved in binding linear ubiquitin chains are required for [NF-kappaB] *activation* by and other agonists , providing an explanation for the detrimental effect of NEMO mutations in patients suffering from X-linked ectodermal dysplasia and immunodeficiency . Positive_regulation NFKB1 TNF 19325144 2080382 activation of siDHCR24 treated cells *increased* expression of VCAM-1 ( 550-fold , P < 0.001 ) and [NF-kappaB] ( 9-fold , P < 0.001 ) that could no longer be suppressed by rHDLs . Positive_regulation NFKB1 TNF 19336568 2056504 Tumor necrosis factor (TNF) receptor associated factor 2 ( TRAF2 ) is an adaptor protein that modulates the activation of the c-Jun NH ( 2 ) terminal kinase ( JNK ) /c-Jun and IkappaB kinase [(IKK)/nuclear factor-kappaB (NF-kappaB)] signaling cascades in *response* to stimulation . Positive_regulation NFKB1 TNF 19340308 2056720 Overexpressed optineurin partly inhibited *induced* [NF-kappaB] activation in Hela cells . Positive_regulation NFKB1 TNF 19340308 2056726 In addition these results suggest that there is a negative feedback loop in which *induced* [NF-kappaB] activity mediates expression of optineurin , which itself functions as a negative regulator of NF-kappaB . Positive_regulation NFKB1 TNF 19347279 2057479 We describe in this chapter three separate methods to determine the effects of this NEMO binding domain (NBD) peptide on pro-inflammatory [NF-kappaB] signaling in *response* to . Positive_regulation NFKB1 TNF 19347944 2057506 *induced* activation of [NF-kappaB] is not altered by 810 nm radiation using 25 J/cm ( 2 ) . Positive_regulation NFKB1 TNF 19367378 2081654 These results suggest that Klotho suppresses *induced* expression of adhesion molecules and [NF-kappaB] activation . Positive_regulation NFKB1 TNF 19369349 2089005 PKR dependent activation of p38 and NF-kappaB was required for vaccinia virus induced INHBA expression , whereas induction of *required* only PKR dependent [NF-kappaB] activation . Positive_regulation NFKB1 TNF 19372735 2074670 We quantitatively compared the efficacy of various proteasome inhibitors ( MG132 , lactacystin and epoxomicin ) and IKK inhibitors ( BAY 11-7082 and PS1145 ) to block [NFkappaB] activity *induced* by or TPA and to sensitize LNCaP prostate carcinoma cells to apoptosis . Positive_regulation NFKB1 TNF 19376732 2081872 Although *increased* DNA binding activity of Ref-1 regulated transcription factors , AP-1 and [NF-kappaB] , to the IL-8 promoter , promoter activity was mainly mediated by NF-kappaB binding . Positive_regulation NFKB1 TNF 19376732 2081881 Silencing of Ref-1 in AGS cells inhibited basal and *induced* AP-1 and [NF-kappaB] DNA binding activity , but not their nuclear accumulation . Positive_regulation NFKB1 TNF 19379593 2065655 It is concluded that the *induces* expressions of IL-8 mRNA , MCP-1 mRNA and [NF-kappaB] in HUVECs , and NF-kappaB activities signal pathway may play a role in IL-8 mRNA and MCP-1 mRNA expressions . Positive_regulation NFKB1 TNF 19383900 2066098 Gel shift for *induced* hiNOS [NF-kappaB] activation showed decreased p50 binding and decreased NF-kappaB reporter activity in the beta-catenin-mutant HAbeta18 cells . Positive_regulation NFKB1 TNF 19383900 2066108 Furthermore , SW480 cells stably transformed with wild-type adenomatous polyposis coli showed decreased beta-catenin protein and increased *induced* p65 [NF-kappaB] binding as well as iNOS and Traf1 expression . Positive_regulation NFKB1 TNF 19393729 2094981 Furthermore , Cardiospermum halicacabum L. ethanol extract inhibited the *induced* DNA binding activity of [NF-kappaB] , which was associated with decreased p65 protein level in the nucleus in Jurkat cells . Positive_regulation NFKB1 TNF 19403345 2157164 However , *induced* activation of [NF-kappaB] was not affected by over activated Notch-1 . Positive_regulation NFKB1 TNF 19404960 2075182 Inhibition of Mcl-1 by EGCG triggered caspase 3 activity in RA synovial fibroblasts , which was mediated via down-regulation of the *induced* Akt and [NF-kappaB] pathways . Positive_regulation NFKB1 TNF 19407978 2070817 These inhibitory actions of CLT were , at least in part , attributable to the inhibition of redox sensitive NF-kappaB activation , as CLT inhibited *induced* ROS generation as well as [NF-kappaB] nuclear translocation and activation in HT29 cells . Positive_regulation NFKB1 TNF 19409903 2082512 Currently , *induced* [NF-kappaB] activation is believed to be impaired in TRAF2 and TRAF5 double knockout ( T2/5 DKO ) cells . Positive_regulation NFKB1 TNF 19411063 2070949 Wu et al. , in this issue of Cancer Cell , show that *dependent* [NFkappaB] activation induces COP9 signalosome mediated inhibition of GSK3beta and the SCF(beta-TRCP) ubiquitin ligase , thus leading to stabilization of the transcription factor Snail and promoting cell migration and metastasis . Positive_regulation NFKB1 TNF 19420112 2106635 Specific inhibitors of caspases-8 and -3 , but not of caspase-1 , reduced induced [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 19420112 2106642 Consistent with this , MLC kinase (MLCK) inhibitor ML-7 reduced *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 19434100 2090351 The TRADD-TRAF2-NIK-IKKalpha/beta signaling cascade , which plays an essential role in *induced* [NF-kappaB] activation , was found to be involved in tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) receptor mediated signal transduction . Positive_regulation NFKB1 TNF 19444283 2114791 In this study , we found that p53 upregulated modulator of apoptosis ( PUMA ) , a p53 downstream target and a BH3-only Bcl-2 family member , is directly regulated by [NF-kappaB] in *response* to . Positive_regulation NFKB1 TNF 19445900 2115285 The inhibition of induced [NF-kappaB] *activation* by marine natural products . Positive_regulation NFKB1 TNF 19445900 2115288 Results obtained show that selected purified compounds had a cytotoxic effect on the human leukaemia cell line K562 , inhibited both *induced* [NF-kappaB-DNA] binding as well as TNF-alpha induced IkappaBalpha degradation and nuclear translocation of p50/p65 . Positive_regulation NFKB1 TNF 19458540 2084697 These data indicate that *mediates* rapid activation of injury induced [NF-kappaB] DNA binding in Schwann cells and that these events are associated with inhibition of postinjury axonal sprouting . Positive_regulation NFKB1 TNF 19464389 2101875 Hirsutenone , dexamethasone , cyclosporin A and Bay 11-7085 inhibited the induced phosphorylation of inhibitory kappaB and the *activation* of [nuclear factor (NF)-kappaB] . Positive_regulation NFKB1 TNF 19464428 2084963 Overexpression of ABINs inhibits [NF-kappaB] *activation* by and several other stimuli . Positive_regulation NFKB1 TNF 19465513 2107386 DMF inhibited *induced* NF-kappaB p65 phosphorylation , NF-kappaB nuclear entry , and [NF-kappaB-DNA] complex formation , whereas PDGF-BB appeared not to activate NF-kappaB within 60 min . Positive_regulation NFKB1 TNF 19472212 2102254 Of note , *induced* [NF-kappaB] may be the primary pathway contributing to CXCL10 production in THP-1 cells . Positive_regulation NFKB1 TNF 19500694 2102961 The results showed that EM inhibited *induced* expressions of RANKL and [NF-kappaB] at both mRNA and protein levels in a concentration dependent manner . Positive_regulation NFKB1 TNF 19509265 2092234 In addition , although SMC3 dramatically reduced c-IAP1 level , it had marginal effect on c-IAP2 expression , induced RIP modification , [NF-kappaB] *activation* , and downstream antiapoptosis NF-kappaB target expression . Positive_regulation NFKB1 TNF 19521662 2108936 Overexpression of WDR34 inhibited IL-1beta- , polyI : C- and lipopolysaccharide (LPS) induced but not *induced* [NF-kappaB] activation , whereas knockdown of WDR34 by a RNA-interference construct potentiated NF-kappaB activation by these ligands . Positive_regulation NFKB1 TNF 19528257 2142365 Previous work , in nonmuscle cells , has shown that Hsp27 inhibits *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 19533666 2109650 *induced* [NF-kappaB] activation enhances cellular mechanisms including proliferation , migration , and invasion . Positive_regulation NFKB1 TNF 19533666 2109652 However , it is unclear whether KiSS1 regulates *induced* [NF-kappaB] activation and further tumor cell migration . Positive_regulation NFKB1 TNF 19533666 2109660 Both KiSS1 overexpression and KP10 ( kisspeptin-10 ) stimulation inhibited *induced* [NF-kappaB] activity , suppressed TNFalpha induced cell migration and cell attachment to fibronectin in breast cancer cells while KP10 has little effect on cancer cell proliferation . Positive_regulation NFKB1 TNF 19533666 2109665 Therefore , our data demonstrate that KiSS1 inhibits *induced* [NF-kappaB] activation via downregulation of RhoA activation and suppression of breast cancer cell migration and invasion . Positive_regulation NFKB1 TNF 19533738 2149492 A thorough screening of the signaling system confirmed that stimulation *up-regulated* [nuclear factor kappaB (NFkappaB)] signaling in SV-HCECs . Positive_regulation NFKB1 TNF 19557502 2157506 Here , we report that overexpression of RIOK3 inhibits *induced* [NF-kappaB] activation , but down-regulation of endogenous RIOK3 expression by siRNA potentiates it . Positive_regulation NFKB1 TNF 19558496 2202628 Furthermore , SFN elevated cellular glutathione levels and antagonized induced [NFkappaB] *transactivation* . Positive_regulation NFKB1 TNF 19559672 2110581 In addition , *increased* [nuclear factor-kappa B (NF-kappaB)] activity in NK cells and inhibition of NF-kappaB impeded TNF-alpha enhanced NK cell maturation . Positive_regulation NFKB1 TNF 19563733 2121999 EZS inhibited [NF-kappaB] activation and IkappaB-alpha phosphorylation *induced* by , subsequent degradation of IkappaB-alpha . Positive_regulation NFKB1 TNF 19572372 2185607 In HEK293 cells , pretreatment with RvE1 inhibited *induced* nuclear translocation of [NF-kappaB] in a ChemR23 dependent manner . Positive_regulation NFKB1 TNF 19576177 2111562 PGG significantly inhibited induced [NF-kappaB] *activation* as well as STAT1 activation . Positive_regulation NFKB1 TNF 19587216 2142601 [NF-kappaB] *activation* by or hydrogen peroxide was FAK independent . Positive_regulation NFKB1 TNF 19590508 2130058 Telmisartan caused a dose dependent suppression of the *induced* activation of [nuclear factor (NF)-kappaB] in vascular endothelial cells in this study . Positive_regulation NFKB1 TNF 19590508 2130060 The thiazolidinediones neither influenced *induced* [NF-kappaB] activation nor influenced the inhibitory effect of telmisartan in this process . Positive_regulation NFKB1 TNF 19592502 2137137 Here , we found that licochalcone A strongly inhibited tumor necrosis ( *induced* nuclear localization , DNA binding activity , and the transcriptional activity of [nuclear factor-kappaB (NF-kappaB)] . Positive_regulation NFKB1 TNF 19592502 2137143 In contrast , a structurally related compound , echinatin , failed to inhibit induced IKK activation and [NF-kappaB] *activation* , suggesting that the 1,1-dimethy-2-propenyl group in licochalcone A is important for the inhibition of NF-kappaB . Positive_regulation NFKB1 TNF 19594939 2111992 It could be demonstrated that the exogenous application of PC inhibits membrane dependent actin assembly and *induced* nuclear [NF-kappaB] activation . Positive_regulation NFKB1 TNF 19594939 2111994 We analysed *induced* [NF-kappaB-activation] via the transient expression of a NF-kappaB-luciferase reporter system . Positive_regulation NFKB1 TNF 19596085 2122920 Since NF-kappaB is an important therapeutic target , we decided to utilize an in vitro screening assay to identify potential inhibitors that block *induced* [NF-kappaB] activation in a C2C12 muscle line stably expressing an NF-kappaB luciferase reporter gene . Positive_regulation NFKB1 TNF 19596777 2122951 While activation of NF-kappaB was essential for heat inactivated S. aureus induced and NO , inhibiting GSK-3beta blocked heat inactivated S. aureus *induced* [NF-kappaB] p65 nuclear translocation . Positive_regulation NFKB1 TNF 19617655 2112465 In addition , propionate significantly inhibited the induced *activation* of [nuclear factor-kappa B (NF-kappaB)] and significantly increased the expression of peroxisome proliferator activated receptor alpha ( PPARalpha ) in HUVEC . Positive_regulation NFKB1 TNF 19619938 2194988 Rosmarinic acid sensitizes cell death through suppression of *induced* [NF-kappaB] activation and ROS generation in human leukemia U937 cells . Positive_regulation NFKB1 TNF 19619938 2194990 Rosmarinic acid ( RA ) , a naturally occurring polyphenol flavonoid , has been reported to inhibit *induced* [NF-kappaB] activation in human dermal fibroblasts . Positive_regulation NFKB1 TNF 19619938 2194993 These results demonstrated that RA inhibits *induced* ROS generation and [NF-kappaB] activation , and enhances TNF-alpha induced apoptosis . Positive_regulation NFKB1 TNF 19620837 2131215 treatment *induced* an elevated activated [NFkappaB/p65] , concomitant with induced p21 levels , which resulted in increased sensitivity to gefitinib in PC-9-ZD cells . Positive_regulation NFKB1 TNF 19628032 2149916 TRP14 inhibits the *induced* [NF-kappaB] activation to a greater extent than Trx1 . Positive_regulation NFKB1 TNF 19643162 2132352 Furthermore , SOCS-3 repressed *induced* degradation of IkappaB , [NFkappaB] DNA binding and transcription of the NFkappaB dependent MnSOD promoter . Positive_regulation NFKB1 TNF 19652376 2118977 CA attenuated *induced* IkappaB degradation and [NF-kappaB] translocation from cytosol to the nucleus . Positive_regulation NFKB1 TNF 19652376 2118979 In conclusion , *induced* [NF-kappaB-DNA] complex formation was inhibited by CA. CA reduced TNF-alpha induced endothelial adhesiveness to HUVECs by inhibiting transcription factor activation , and CAMs expression suggesting its potential role in atherosclerosis diseases . Positive_regulation NFKB1 TNF 19660542 2138628 Furthermore , prefeeding LGG prevented *induced* intestinal [NF-kappaB] activation . Positive_regulation NFKB1 TNF 19666475 2144050 NEMO and IKKbeta are essential for induced [NF-kappaB] *activation* , and we recently demonstrated that NEMO and IKKalpha are sufficient for interleukin (IL)-1 induced signaling . Positive_regulation NFKB1 TNF 19689081 2126520 The results suggested LPS might activate [NF-kappaB] in peritoneal macrophages and *induce* the increase of transcription and expression of , IL-1beta , IL-6 genes ; Positive_regulation NFKB1 TNF 19706600 2151481 Here we report that tumor necrosis factor-alpha (TNFalpha) induces RelA polyubiquitination at the lysine 195 residue , and this ubiquitination event is critical for the degradation of RelA and termination of mediated [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 19706600 2151486 Our finding is the first report that substitution of a key RelA lysine residue with arginine inhibits TNFalpha induced RelA ubiquitination and enhances induced [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 19710421 2144808 Restoration of importin alpha3 levels sustained [NF-kappaB] *activation* by during PHB transfection . Positive_regulation NFKB1 TNF 19711042 2127345 Hepatitis delta virus large antigen sensitizes to *induced* [NF-kappaB] signaling . Positive_regulation NFKB1 TNF 19711042 2127347 In this study , we demonstrated that *induced* [NF-kappaB] transcriptional activation was increased by LHDAg but not by SHDAg in both HEK293 and Huh7 cells . Positive_regulation NFKB1 TNF 19714766 2202728 In response to apically applied natural commensal-origin DNA , polarized HT-29 and T84 cells enhanced expression of TLR9 in a specific manner , which was subsequently associated with attenuation of *induced* [NF-kappaB] activation and NF-kappaB mediated IL-8 expression . Positive_regulation NFKB1 TNF 19726342 2134031 *induced* the activation of [NF-kappaB] and increased the expressions of IL-6 and sICAM-1 in HUVECs . Positive_regulation NFKB1 TNF 19735646 2183312 When examined by electrophoretic gel shift mobility assay , curcumin ( NP ) was more active than curcumin in inhibiting *induced* [NF-kappaB] activation and in suppression of NF-kappaB regulated proteins involved in cell proliferation ( cyclin D1 ) , invasion ( MMP-9 ) , and angiogenesis ( VEGF ) . Positive_regulation NFKB1 TNF 19739098 2163232 Based on our previous observations that the nutrient flavonoid luteolin potently blocks *induced* [NF-kappaB] activation in cancer cells , we investigated if the combination of SMC3 and luteolin would achieve a synergistic anticancer activity . Positive_regulation NFKB1 TNF 19751407 2135259 Inhibition of *induced* activation of [NF-kappaB] by hantavirus nucleocapsid proteins . Positive_regulation NFKB1 TNF 19751727 2147300 We recently reported that diacylglycerol kinase (DGK) alpha enhanced induced *activation* of [nuclear factor-kappaB (NF-kappaB)] . Positive_regulation NFKB1 TNF 19751727 2147306 These results strongly suggest that DGKalpha positively regulates *dependent* [NF-kappaB] activation via the PKCzeta mediated Ser311 phosphorylation of p65/RelA . Positive_regulation NFKB1 TNF 19760502 2264287 Moreover , *promoted* ErbB-2/ErbB-3 heterocomplex formation , Akt activation and [NF-kappaB] transcriptional activation . Positive_regulation NFKB1 TNF 19760502 2264289 Inhibition of ErbB-2 by addition of AG825 , an epidermal growth factor receptor/ErbB-2-tyrosine kinase inhibitor , or knockdown of ErbB-2 by RNA interference strategy , blocked induced [NF-kappaB] *activation* and proliferation . Positive_regulation NFKB1 TNF 19763702 2175978 High fat diet increased hepatic levels of SREBP-1c , TLR4 , , and IL-6 protein and mRNA and increased *activation* of [p65NF-kappaB] . Positive_regulation NFKB1 TNF 19765578 2153529 In addition , M1-M4 significantly suppressed *induced* [NF-kappaB] transcriptional activity . Positive_regulation NFKB1 TNF 19765578 2153531 Treatment of HT-29 cells with M1 and PDTC , a NF-kappaB inhibitor , synergistically suppressed both *induced* [NF-kappaB] activation and monocytic cell adhesion to HT-29 cells . Positive_regulation NFKB1 TNF 19768141 2140934 The effect of Tq on the constitutive and *induced* activation and nuclear translocation of [NF-kappaB] was examined by ELISA and immunohistochemistry . Positive_regulation NFKB1 TNF 19768141 2140937 Tq also inhibited the constitutive and *mediated* activation of [NF-kappaB] in PDA cells and reduced the transport of NF-kappaB from the cytosol to the nucleus . Positive_regulation NFKB1 TNF 19770515 2147453 TRAF3 siRNA prevented *induced* [NF-kappaB] p100 accumulation and inhibition of osteoclastogenesis . Positive_regulation NFKB1 TNF 19810754 2159671 It has been assumed that TRAF2 is a ubiquitin ligase like TRAF6 and mediates K63 linked polyubiquitination of RIP1 , a kinase pivotal in induced [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 19814997 2184078 Heteronemin , a spongean sesterterpene , inhibits *induced* [NF-kappa B] activation through proteasome inhibition and induces apoptotic cell death . Positive_regulation NFKB1 TNF 19827018 2209356 Moreover , baicalin inhibited the nuclear translocation of [NF-kappaB] *induced* by H/R or . Positive_regulation NFKB1 TNF 19830703 2164834 Further , CC2 and LZ peptides attenuate RANKL- and *induced* [NF-kappaB] signaling in bone marrow derived osteoclast precursors ( OCPs ) . Positive_regulation NFKB1 TNF 19842893 2155391 After treated with HES , these provoked perianastomotic tissue MPO activity , MDA levels , [NF-kappa B] *activation* , and plasma levels of and IL-6 were suppressed and GSH levels were restored , especially in 15 ml/kg HES group . Positive_regulation NFKB1 TNF 19858207 2170404 We showed that kallistatin inhibits *induced* [NF-kappaB] activation , as well as vascular cell adhesion molecule-1 and monocyte chemoattractant protein-1 expression in endothelial cells , whereas knockdown of KLF4 by small interfering RNA oligonucleotide abolished the effect of kallistatin . Positive_regulation NFKB1 TNF 1986224 152166 The *activation* of [NF-kappa B-like] activities ( called NF-kappa B ) by and the phorbol ester phorbol 12-myristate 13-acetate ( PMA ) were compared . Positive_regulation NFKB1 TNF 1986224 152168 [NF-kappa B] *activation* by was initially cycloheximide insensitive , but maintenance of NF-kappa B activity required ongoing protein synthesis and continuous stimulation by TNF alpha . Positive_regulation NFKB1 TNF 1986224 152172 We suggest that cell-specific differences in the protein kinase C-dependent activation of NF-kappa B may exist and that and PMA may *induce* expression of the gene ( s ) encoding [NF-kappa B] . Positive_regulation NFKB1 TNF 19874203 2258361 We investigated the effects of EPA on differentiation of RAW264.7 monocyte/macrophage cells induced by receptor activator of NF-kappaB ligand ( RANKL ) and on *activation* of [NF-kappaB] by or exposure to modeled weightlessness . Positive_regulation NFKB1 TNF 19874889 2184456 USP11 negatively regulates *induced* [NF-kappaB] activation by targeting on IkappaBalpha . Positive_regulation NFKB1 TNF 19874889 2184464 Moreover , knockdown of USP11 expression enhances induced IkappaBalpha ubiquitination and [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 19874889 2184467 These data demonstrate that USP11 plays an important role in the downregulation of mediated [NF-kappaB] *activation* through modulating IkappaBalpha stability . Positive_regulation NFKB1 TNF 19874889 2184472 In addition , overexpression of a catalytically inactive USP11 mutant partially inhibits TNFalpha- and IKKbeta induced NF-kappaB activation , suggesting that USP11 also exerts a non-catalytic function in its negative regulation of mediated [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 19874889 2184478 Thus , IkappaBalpha ubiquitination and deubiquitination processes function as a Yin-Yang regulatory mechanism on *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 19875812 2187917 Overexpression of C/EBPbeta markedly suppressed *induced* activation of [NF-kappaB] , independent of its transacting potential . Positive_regulation NFKB1 TNF 19887769 2197287 Both and IL-1beta *activated* [NF-kappaB] and stimulated IL-8 production . Positive_regulation NFKB1 TNF 19897171 2197449 Intra-abdominal sepsis led to significant decreases in colonic anastomotic bursting pressures , perianastomotic tissue HP contents , GSH levels , and plasma levels of PC , along with increases in perianastomotic tissue MPO activity , MDA levels , [NF-kappaB] *activation* , and plasma levels of , IL-6 , and d-dimer . Positive_regulation NFKB1 TNF 19910467 2189301 Ubiquitination and deubiquitination of receptor interacting protein 1 (RIP1) play an important role in the positive and negative regulation of the induced [nuclear factor kappaB (NF-kappaB)] *activation* . Positive_regulation NFKB1 TNF 19910467 2189304 Therefore , our results demonstrate that USP21 plays an important role in the down-regulation of *induced* [NF-kappaB] activation through deubiquitinating RIP1 . Positive_regulation NFKB1 TNF 19927158 2203743 Furthermore , several cell types from E18 RIPK1 ( -/- ) embryos seem to activate [NF-kappaB] in *response* to . Positive_regulation NFKB1 TNF 19934328 2172246 TRADD is a crucial transducer for *induced* [nuclear factor-kappaB (NF-kappaB)] activation . Positive_regulation NFKB1 TNF 19934328 2172252 Knocking down TRADD expression in LNCaP cells impaired *induced* [NF-kappaB] activation and androgen receptor repression , whereas overexpression of TRADD in C4-2B cells restored their sensitivity to TNF-alpha . Positive_regulation NFKB1 TNF 19958645 2174361 The expression and localization of NF-kappaB in HCC tissues are obviously different from those in the surrounding normal liver tissues , and the level of nucleoprotein NF-kappaB in HCC tissues is correlated with expressed TNF alpha , suggesting that can *activate* [NF-kB] , the activated NF-kB then translocates to the nucleus and plays important role in the carcinogenesis of HCC . Positive_regulation NFKB1 TNF 19959714 2204098 FAT10 is a TNF-alpha-inducible ubiquitin-like protein with a putative role in immune response , but whether FAT10 participates in *induced* [NF-kappaB] activation is unknown . Positive_regulation NFKB1 TNF 19959714 2204100 Here , using renal tubular epithelial cells ( RTECs ) derived from FAT10 ( -/- ) and FAT10 ( +/+ ) mice , we observed that FAT10 deficiency abrogated *induced* [NF-kappaB] activation and reduced the induction of NF-kappaB regulated genes . Positive_regulation NFKB1 TNF 19962318 2199492 Screening of six compounds for the ability to inhibit *induced* [NF-kappaB] activity revealed that compound SK2009 was the most potent of these compounds in suppressing NF-kappaB activation in KBM-5 leukemic cells . Positive_regulation NFKB1 TNF 19966295 2190825 Indole also decreased mediated *activation* of [NF-kappaB] , expression of the proinflammatory chemokine IL-8 , and the attachment of pathogenic E. coli to HCT-8 cells , as well as increased expression of the antiinflammatory cytokine IL-10 . Positive_regulation NFKB1 TNF 20005846 2174904 LUBAC enhances NEMO interaction with the TNF-RSC , stabilizes this protein complex , and is required for efficient induced *activation* of [NF-kappaB] and JNK , resulting in apoptosis inhibition . Positive_regulation NFKB1 TNF 20018848 2204631 Azadirachtin blocks induced *activation* of [nuclear factor kappaB (NF-kappaB)] and also expression of NF-kappaB dependent genes such as adhesion molecules and cyclooxygenase 2 . Positive_regulation NFKB1 TNF 20022690 2232334 [Nuclear factor-kappa B (NF-kappaB)] *activation* by attenuates the TNF-alpha induced apoptosis pathway . Positive_regulation NFKB1 TNF 20022690 2232336 Such sensitization is closely associated with the inhibitory effect of HA14-1 on mediated [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 20032777 2205155 SHetA2 inhibited basal and *induced* or hydrogen peroxide induced [NF-kappaB] activity through counter-regulation of upstream kinase ( IkappaB kinase ) activity , inhibitor protein ( IkappaB-alpha ) phosphorylation , and p-65 NF-kappaB subunit nuclear translocation , but independently of reactive oxygen species generation . Positive_regulation NFKB1 TNF 20039412 2192703 *stimulated* translocation of [NF-kappaB] into the nucleus and NF-kappaB promoter activity were blocked by Bay11-7082 , but not by U0126 , SB202190 , or SP600125 . Positive_regulation NFKB1 TNF 20045454 2205379 The *activation* of [NF-kappaB] by was completely blocked by a Lagerstroemia speciosa extract in a dose- and time dependent manner in H9c2 cells . Positive_regulation NFKB1 TNF 20049872 2200699 activated ERK and *increased* [NF-kappaB] promoter activity . Positive_regulation NFKB1 TNF 20052674 2211738 *Activation* of [NF-kappaB] by enhances p50/RelA binding to the NF-kappaB binding sites . Positive_regulation NFKB1 TNF 20054232 2211850 In addition , treatment with GFW significantly suppressed *induced* reactive oxygen species production and [NF-kappaB] transcriptional activity in HT-29 cells . Positive_regulation NFKB1 TNF 20065354 2225505 In contrast , TRAF2 siRNA knockdown , targeting receptor mediated NF-kappaB activation , blocked but not HDACI *mediated* [NF-kappaB] activation and lethality . Positive_regulation NFKB1 TNF 20071450 2194124 Low *induced* [NF-kappaB] and p38 phosphorylation levels in leucocytes in tumour necrosis factor receptor associated periodic syndrome . Positive_regulation NFKB1 TNF 20071450 2194127 Because the pathomechanism of TRAPS may involve aberrant TNF mediated intracellular signalling , we examined phosphorylation levels of [nuclear factor kappaB (NF-kappaB)] and p38 in *response* to in 10 patients with three different TNFRSF1A mutations ( C73R , C88Y and F112I ) . Positive_regulation NFKB1 TNF 20072622 2194143 Degraded carrageenan causing colitis in rats *induces* secretion and ICAM-1 upregulation in monocytes through [NF-kappaB] activation . Positive_regulation NFKB1 TNF 20080763 2194359 increased caspase-3 activity but *activated* neither [NF-kappaB] nor JNK in Tak1-deficient hepatocytes . Positive_regulation NFKB1 TNF 20098747 2201945 Overexpression of CALB1 , CDK2 and SAG was found to stimulate transcriptional activation by NF-kappaB , while SYT1 overexpression repressed *dependent* [NF-kappaB] transcriptional activation in human embryonic kidney cells . Positive_regulation NFKB1 TNF 20100622 2226347 The isolated compounds were evaluated for their cancer chemopreventive potential based on their ability to inhibit *induced* [NF-kappaB] activity , nitric oxide ( NO ) production , aromatase , quinone reductase 2 (QR2) and COX-1/-2 activities . Positive_regulation NFKB1 TNF 20100622 2226349 Palmatosides B ( 2 ) and C ( 3 ) inhibited *induced* [NF-kappaB] activity with IC ( 50 ) values of 15.7 and 24.1 microM , respectively ; Positive_regulation NFKB1 TNF 20103840 2178627 UCB prevented the nuclear translocation of [NF-kappaB] *induced* by . Positive_regulation NFKB1 TNF 20104512 2272246 A further analysis indicated that EGJ attenuated *induced* nuclear p65 [nuclear factor-kappa B (NF-kappaB)] translocation , suggesting that EGJ primarily affects the TNF-alpha induced NF-kappaB signaling pathway . Positive_regulation NFKB1 TNF 20104512 2272248 Taken together , we provided here the first evidence showing that EGJ is able to inhibit *induced* [NF-kappaB] activation , adhesion molecule expression , and monocyte-endothelial interaction , suggesting an anti-inflammatory role of EGJ , which may be useful in preventing vascular diseases , such as atherosclerosis . Positive_regulation NFKB1 TNF 20126461 2207217 In cultured tubular cells , TWEAK and *activated* different DNA binding [NFkappaB] complexes . Positive_regulation NFKB1 TNF 20130413 2293652 stimulation *activated* [NF-kappaB] through induction of IkappaB phosphorylation , but the activation can be suppressed by TSA . Positive_regulation NFKB1 TNF 20135642 2235889 *mediated* an increase of [NF-kappaB-specific] DNA-protein complex formation , p65 translocation into nucleus , NF-kappaB-luciferase activity was inhibited by KP392 , Akt inhibitor , and rapamycin . Positive_regulation NFKB1 TNF 20138025 2227039 We found that bisdemethylcurcumin ( BDC ) was more potent than curcumin as an anti-inflammatory agent as indicated by suppression of *induced* [NF-kappaB] activation , more potent as an anti-proliferative agent , and more potent in inducing ROS . Positive_regulation NFKB1 TNF 20138622 2280972 N-acetylcysteine , SP600125 ( JNK inhibitor ) and SB203580 ( p38 MAPK inhibitor ) attenuated *induced* DNA binding activities of both AP-1 and [NF-kappaB] . Positive_regulation NFKB1 TNF 20147406 2227468 Expression of ORFV024 in cell cultures significantly decreased lipopolysaccharide (LPS)- and *induced* [NF-kappaB-responsive] reporter gene expression . Positive_regulation NFKB1 TNF 20147406 2227472 Further , ORFV024 expression decreased *induced* phosphorylation and nuclear translocation of [NF-kappaB-p65] , phosphorylation , and degradation of IkappaBalpha , and phosphorylation of IkappaB kinase (IKK) subunits IKKalpha and IKKbeta , indicating that ORFV024 functions by inhibiting activation of IKKs , the bottleneck for most NF-kappaB activating stimuli . Positive_regulation NFKB1 TNF 20153843 2236120 Previously , we reported that a major component , Licochalcone A , potently inhibited induced [NF-kappaB] *activation* by inhibiting IKKbeta activation . Positive_regulation NFKB1 TNF 20153843 2236124 Interestingly , reduced Licochalcone A , which lacks a double bond , failed to inhibit *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 20168983 2180746 We also demonstrate that Rottlerin prevents dependent [NFkappaB] *activation* in MCF-7 cells and in HT-29 cells transfected with the NFkappaB-driven plasmid pBIIX-LUC , suggesting that Rottlerin can inhibit NFkappaB via several pathways and in several cell types . Positive_regulation NFKB1 TNF 20185819 2236861 In contrast , *activation* of [NFkappaB] by did not depend on TRAF3 levels . Positive_regulation NFKB1 TNF 20195534 2216368 Analysis of [NF-kappaB] activation in *response* to in MEFs reveals that IKKbeta is essential for efficient phosphorylation and subsequent degradation of IkappaB alpha , yet IKKalpha contributes to the NF-kappaB activation response in these cells as measured via DNA binding assays . Positive_regulation NFKB1 TNF 20196785 2180967 In addition , treatments involving E ( 2 ) , membrane-impermeable BSA-E ( 2 ) and/or Dox , which induces ERalpha overexpression , significantly inhibited LPS induced apoptosis by suppressing LPS-up regulated JNK1/2 activity , IkappaB degradation , [NFkappaB] *activation* and pro-apoptotic proteins ( e.g . , active caspases-8 , t-Bid , Bax , released cytochrome c , active caspase-9 , active caspase-3 ) in myocardial cells . Positive_regulation NFKB1 TNF 20200474 2265330 It has been shown that NQO1 is also essential for the *induced* activation of [NF-kappaB] and that beta-lap suppresses the TNF induced NF-kappaB activation . Positive_regulation NFKB1 TNF 20205746 2229739 significantly *induced* phosphorylation of [NFkappaB] at Ser 536 and Ser 468 , but not at Ser 529 or Ser 276 . Positive_regulation NFKB1 TNF 20205746 2229773 These results strongly suggest that *induces* IL-6 synthesis through the JAK/STAT3 pathway in addition to p38 MAP kinase and SAPK/JNK in C6 glioma cells , and that phosphorylation of [NFkappaB] at Ser 536 and Ser 468 , and NADPH oxidase are involved in TNF-alpha stimulated IL-6 synthesis . Positive_regulation NFKB1 TNF 20220144 2249440 As IL-17 stimulation stabilizes the IkappaB-zeta transcript , we propose a model where *induces* activation and binding of [NF-kappaB] to the promoters of both NFKBIZ and LCN2 genes but induce only transcription of IkappaB-zeta . Positive_regulation NFKB1 TNF 20226764 2237551 In addition , IRS-3 augmented the binding activity of p50 to the NF-kappaB DNA binding site , as well as the *induced* transcriptional activity of [NF-kappaB] . Positive_regulation NFKB1 TNF 20231278 2254520 Maml1-deficient mouse embryonic fibroblasts showed impaired *induced* [NF-kappaB] responses . Positive_regulation NFKB1 TNF 20231449 2230274 Activities tested included inhibition of : HCV cell culture infection , NS5B polymerase activity , *induced* [NF-kappaB] transcription , virus induced oxidative stress , and T-cell proliferation . Positive_regulation NFKB1 TNF 20237236 2259891 *caused* activation of [NF-kappaB] , MAP kinases , and PI3K-Akt in podocytes , whereas blockade of these molecules did not affect inhibition of RAR by TNF-alpha . Positive_regulation NFKB1 TNF 20300512 2230411 When challenged with either intratracheal zymosan or LPS , NADPH oxidase-deficient p47 ( phox-/- ) mice and gp91(phox)-deficient mice developed exaggerated and progressive lung inflammation , augmented [NF-kappaB] *activation* , and elevated downstream pro-inflammatory cytokines ( , IL-17 , and G-CSF ) compared to wildtype mice . Positive_regulation NFKB1 TNF 20337659 2287565 1. The novel nuclear factor (NF)-kappaB inhibitor dehydroxymethylepoxyquinomicin ( DHMEQ ) is a derivative of the antibiotic epoxyquinomicin C from Amycolatopsis sp. that has been found to inhibit induced *activation* of [NF-kappaB] by suppressing nuclear translocation of NF-kappaB . Positive_regulation NFKB1 TNF 20350779 2281936 In contrast , [NF-kappaB] *activation* by or expression of constitutively active IKK2 induced an EMT-phenotype with up-regulation of vimentin and ZEB1 , and down-regulation of E-cadherin . Positive_regulation NFKB1 TNF 20353839 2273288 *Activation* of [NF-kappaB] by fluid shear stress , but not , requires focal adhesion kinase in osteoblasts . Positive_regulation NFKB1 TNF 20353839 2273290 We examined the role of a key component of focal adhesions and of mechanotransduction , focal adhesion kinase ( FAK ) in regulation of FSS- and *induced* activation of [nuclear factor-kappa B (NF-kappaB)] signaling in osteoblasts . Positive_regulation NFKB1 TNF 20356846 2266541 The RING functions of cIAP1 are required for full induced *activation* of [NF-kappaB] , however , delayed activation of NF-kappaB still occurs in cIAP1 and -2 double knock-out cells . Positive_regulation NFKB1 TNF 20363280 2261071 Further studies revealed that EC extracts suppress the production of and *activation* of [nuclear factor-kappa B (NF-kappaB)] . Positive_regulation NFKB1 TNF 20367887 2245058 In this study , we demonstrate that MA significantly enhanced TNFalpha induced inhibition of pancreatic cancer cell proliferation , invasion , and potentiated TNFalpha induced cell apoptosis by suppressing induced [NF-kappaB] *activation* in a dose- and time dependent manner . Positive_regulation NFKB1 TNF 20368026 2238481 these results indicate that E1A protein upregulated [NF-kappaB] transcription activity *induced* by LPS and in rat alveolar epithelial cells and this effect could be repressed by NAC . Positive_regulation NFKB1 TNF 20370892 2273379 In vitro , HpTNFR1 reduced the TNFR1 mRNA expression by three-fold resulting in a 70 % reduction of *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 20372995 2261764 however , was unable to *induce* [NF-kappaB] in post-intervention samples , suggesting that the mixture of four important natural agents could be useful to protect humans against oxidative stress . Positive_regulation NFKB1 TNF 20378831 2273551 *induced* [NF-kappaB] activation was blocked and IkappaBalpha expression was higher in HCT116 cells lacking DNMT than in parental cells . Positive_regulation NFKB1 TNF 20385167 2267203 Also , 1alpha,25 ( OH ) ( 2 ) D ( 3 ) did not suppress the *activation* of [NF-kappaB] by or PHA . Positive_regulation NFKB1 TNF 20385564 2267211 To study the involvement of NF-kappaB in G ( 1 ) /S phase regulation , the levels of selected transcriptional regulators were monitored following overexpression of [NF-kappaB] or its physiological *induction* by . Positive_regulation NFKB1 TNF 20404154 2255862 Chromatin immunoprecipitation assays further indicate that estrogen suppresses *induced* [NFkappaB] recruitment to the CCL2 enhancer . Positive_regulation NFKB1 TNF 20410444 2307413 Characterization of the human biliverdin reductase gene structure and regulatory elements : promoter activity is enhanced by hypoxia and suppressed by *activated* [NF-kappaB] . Positive_regulation NFKB1 TNF 20440096 2282728 *activated* the [NF-kappaB] and the JNK pathways . Positive_regulation NFKB1 TNF 20448200 2262757 In particular , vinpocetine inhibits *induced* [NF-kappaB] activation and the subsequent induction of proinflammatory mediators in multiple cell types , including vascular smooth muscle cells , endothelial cells , macrophages , and epithelial cells . Positive_regulation NFKB1 TNF 20462248 2283151 14-3-3 epsilon dynamically interacts with key components of mitogen activated protein kinase signal module for selective modulation of the *induced* time course dependent [NF-kappaB] activity . Positive_regulation NFKB1 TNF 20462248 2283155 We then postulated a mechanistic view describing how 14-3-3 epsilon coordinates its dynamic interactions with TAK1 and PPM1B for differentially modulating *induced* changes in [NF-kappaB] activity . Positive_regulation NFKB1 TNF 20472834 2301096 IFNgamma and *activate* [NF-kappaB] that in turn induces B7-H1 expression on MDS blasts . Positive_regulation NFKB1 TNF 20478530 2263055 TAK1 mediated cancer suppression is exerted through activating [NF-kappaB] in *response* to and through preventing Caspase-3 dependent hepatocyte and cholangiocyte apoptosis . Positive_regulation NFKB1 TNF 20481500 2276148 Fijiolides A and B , inhibitors of *induced* [NFkappaB] activation , from a marine derived sediment bacterium of the genus Nocardiopsis . Positive_regulation NFKB1 TNF 20481500 2276150 Fijiolide A , a potent inhibitor of *induced* [NFkappaB] activation , along with fijiolide B , were isolated from a marine derived bacterium of the genus Nocardiopsis . Positive_regulation NFKB1 TNF 20481500 2276152 Fijiolide A reduced *induced* [NFkappaB] activation by 70.3 % , with an IC ( 50 ) value of 0.57 micro-M . Positive_regulation NFKB1 TNF 20482259 2294617 We have established a standardized method for preparing aqueous extracts ( teas ) from the selected medicinal herbs and screened for inhibition of *induced* activation of [nuclear factor kappaB (NF-kappaB)] , which is the central signaling pathway of the inflammatory response . Positive_regulation NFKB1 TNF 20482842 2276192 Further , inactivation of Bcr-Abl by imatinib pretreatment did not abrogate the induced [NF-kappaB] *activation* while silencing p65 by siRNA did not affect the levels of Bcr-Abl , both results together indicating that NF-kappaB inactivation and Bcr-Abl inhibition may be parallel independent pathways . Positive_regulation NFKB1 TNF 20484576 2288694 PLK1 inhibits [NF-kappaB] transcriptional activation *induced* by , IL-1beta , or several activators , but not by nuclear transcription factor p65 . Positive_regulation NFKB1 TNF 20484576 2288702 PLK1 expression reduces the DNA binding activity of [NF-kappaB] *induced* by . Positive_regulation NFKB1 TNF 20484867 2276259 NAC inhibited *induced* phosphorylation of JNK and p38 but not [NF-kappaB] . Positive_regulation NFKB1 TNF 20499049 2276478 The results obtained from this study revealed that CTB glycoprotein ( 100 microg/ml ) inhibits the translocation of PKC from cytosol to the membrane , the phosphorylation of p38 MAPK , the *activation* of [NF-kappaB] , and the expression levels of and IL-6 . Positive_regulation NFKB1 TNF 20511226 2289465 We previously reported that methyl-beta-cyclodextrin eliminates caveolae and blocks tumor necrosis factor (TNF) induced internalization of TNFR1 but not induced *activation* of [NF-kappaB] in EA.hy926 cells . Positive_regulation NFKB1 TNF 20511226 2289468 Both knockdowns reduce total TNFR1 protein expression , but neither prevents TNFR1 localization to low density membrane domains , induced internalization of TNFR1 , or [NF-kappaB] *activation* by TNF . Positive_regulation NFKB1 TNF 20514534 2289507 These results link the gliadin derived peptides induced production through cAMP dependent PKA activation , where ion channels controlling calcium influx into cells could play a protective role , and *requires* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 20519138 2289582 In addition , icariin suppressed the secretion of , prostaglandin E2 ( PGE ( 2 ) ) and nitric oxide ( NO ) as well as [NF-kappaB] p65 *activation* . Positive_regulation NFKB1 TNF 20523058 2271282 In this mechanism , may *activate* [NF-kappaB] , in cooperation with TLR3 signaling . Positive_regulation NFKB1 TNF 20529958 2289644 In contrast , *activation* of [NF-kappaB] by was not affected . Positive_regulation NFKB1 TNF 20538607 2301911 Results of Sp1 , Sp3 , and Sp4 knockdown by RNA interference demonstrate that both p50 and p65 are Sp-regulated genes and that inhibition of constitutive or *induced* [NFkappaB] by curcumin is dependent on down-regulation of Sp1 , Sp3 , and Sp4 proteins by this compound . Positive_regulation NFKB1 TNF 20540783 2284776 Commensal depletion decreased TLR4 expression as well as [NF-kappaB] *activation* of intestine , myeloperoxidase (MPO) activity as well as expression of lung , and bacterial killing activity of peritoneal cells . Positive_regulation NFKB1 TNF 20555427 2279747 In addition , PGE1 suppressed *induced* [NF-kappaB] activation and production of reactive oxygen species . Positive_regulation NFKB1 TNF 20558233 2302440 To elucidate the molecular mechanism of inhibition of cell adhesion molecules , we investigated the status of nuclear transcription factor-kappaB ( NF-kappaB ) and were able to establish that beta-sitosterol significantly blocked the *induced* activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 20562516 2290159 NAC also inhibited *induced* phosphorylation of Akt and [NF-kappaB] . Positive_regulation NFKB1 TNF 20562516 2290166 W-7 and KN93 inhibited *induced* phosphorylation of Akt but not [NF-kappaB] . Positive_regulation NFKB1 TNF 20566746 2296078 In ccRCC organ cultures , increases TNFR1 , *activates* apoptotic signaling kinase and [NF-kappaB] , and promotes apoptosis in malignant TECs . Positive_regulation NFKB1 TNF 20571239 2280269 We further examined the molecular mechanisms and found that the combination of Sal B and LSS treatment dramatically inhibited *induced* [NF-kappaB] activation evidenced by IkappaBalpha degradation and p65 nuclear translocation in HAECs . Positive_regulation NFKB1 TNF 20576605 2303178 it inhibited [NF-kappaB] activation *induced* by , phorbol 12-myristate 13-acetate , lipopolysaccharide , and cigarette smoke . Positive_regulation NFKB1 TNF 20581820 2285562 We developed a stochastic mathematical model that reproduces both the digital and analogue dynamics as well as most gene expression profiles at all measured conditions , constituting a broadly applicable model for *induced* [NF-kappaB] signalling in various types of cells . Positive_regulation NFKB1 TNF 20593161 2309245 We therefore examined the effect of liraglutide on *induced* [NF-kappaB] activation and NF-kappaB dependent expression of proinflammatory genes . Positive_regulation NFKB1 TNF 20599780 2303588 Using the electrophoretic mobility shift assay , we found that CDC was more active than free curcumin in inhibiting *induced* activation of the inflammatory transcription factor [NF-kappaB] and in suppressing gene products regulated by NF-kappaB , including those involved in cell proliferation ( cyclin D1 ) , invasion ( MMP-9 ) , and angiogenesis ( VEGF ) . Positive_regulation NFKB1 TNF 20599928 2290855 These data suggest that CAPE inhibits *dependent* [NFkappaB] activation via direct inhibition of IKK as well as activation of Nrf2 pathway , in which the functional groups in CAPE may be involved . Positive_regulation NFKB1 TNF 20600852 2303725 In this study , we show that KEAP1 is a new IKK binding partner , which is responsible for the down-regulation of *stimulated* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 2065663 162430 NAC and other thiol compounds also blocked the *activation* of [NF-kappa B] by cycloheximide , double stranded RNA , calcium ionophore , , active phorbol ester , interleukin-1 , lipopolysaccharide and lectin . Positive_regulation NFKB1 TNF 20691659 2311991 Using a knockdown approach in Ewing sarcoma cells , we demonstrated that EWS-FLI1 has no influence on NFkappaB basal activity , but impairs *induced* [NFkappaB-driven] transcription , at least in part through inhibition of NFkappaB binding to DNA . Positive_regulation NFKB1 TNF 20700770 2312400 25HC also decreased cytoplasmic IkappaBalpha levels and further increased *induced* [NFkappaB] activation . Positive_regulation NFKB1 TNF 20704259 2312784 TNF receptor ubiquitous scaffolding and signaling protein (TRUSS) , a 90.1 kDa TNF-R1 associated scaffolding protein , also interacts with TRAF2 and IKK and contributes to *induced* [nuclear factor-kappaB (NF-kappaB)] and c-Jun-NH ( 2 ) -terminal kinase ( JNK ) activation . Positive_regulation NFKB1 TNF 20724660 2317994 Virus induced IRF3 and NF-kappaB activation , as well as K27 linked NEMO polyubiquitination , were abrogated in TRIM23 knockdown cells , whereas TRIM23 knockdown had no effect on mediated [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 20729202 2335713 Synergistic *activation* of [NF-{kappa}B] by bacterial chemoattractant and } is mediated by p38 MAPK dependent RelA acetylation . Positive_regulation NFKB1 TNF 20839630 2319103 All compounds derived from black pepper suppressed induced [NF-kappaB] *activation* , but alkyl amides , compound 4 from black pepper and 5 from hot pepper , were most effective . Positive_regulation NFKB1 TNF 20953353 2333449 While only *activates* canonical [NF-kappaB] signaling , TWEAK promotes both canonical and noncanonical NF-kappaB activation in tubular cells , regulating different inflammatory responses . Positive_regulation NFKB1 TNF 21109521 2383538 Changes in expression of membrane , [NF-{kappa}B] *activation* and neutrophil apoptosis during active and resolved inflammation . Positive_regulation NFKB1 TNF 2115119 137391 Comparison of the *induced* factor and lipopolysaccharide induced [NF-kappa B] in gel mobility shift assays upon partial protease digestion suggests similar DNA binding protein cores . Positive_regulation NFKB1 TNF 21196314 2373979 In the TGase 2-inducible EcR23/TG cell line , TGase 2 over-expression resulted in sustained activation of [NF-kappa B] in the *presence* of , for up to 24 hrs , while in the absence of TGase 2 induction , NF-kappaB activity was restored to basal levels within 6 hrs of TNF-alpha treatment . Positive_regulation NFKB1 TNF 21196321 2373982 DNA binding assays revealed that combination treatment suppressed both basal and *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 21208380 2396948 TNFAIP3 encodes the ubiquitin modifying enzyme , also known as A20 , which is a cytoplasmic zinc finger protein that inhibits [nuclear factor kappa-B (NFKB)] activity and *mediated* programmed cell death . Positive_regulation NFKB1 TNF 21283748 2387867 Here we report that human monocytes treated with SEA , SEB , or anti-MHC class II monoclonal antibodies up regulated MyD88 expression , induced *activation* of [NF-kB] , and increased expression of IL-1R1 accessory protein , and IL-1ß . Positive_regulation NFKB1 TNF 21343177 2431548 Thymosin beta4 inhibits induced [NF-kappaB] *activation* , IL-8 expression , and the sensitizing effects by its partners PINCH-1 and ILK . Positive_regulation NFKB1 TNF 21375727 2404366 While the extract stimulated PPAR? dependent luciferase activity and activated AMPK in C2C12 cells , it inhibited *stimulated* [IKKß/NFkB] signaling and attenuated ER stress in HepG2 cells . Positive_regulation NFKB1 TNF 2146676 144083 Our finding that *induction* of [NF-kappa B] by or antibody to CD3 is not sufficient to induce HIV enhancer dependent transcription in cloned T cells contrasts with results obtained in most lymphoblastoid T-cell lines and indicates that normal T lymphocytes differ from tumoral T cells in terms of requirements for HIV LTR activation . Positive_regulation NFKB1 TNF 21528184 479056 For NF-kappa B , this was in apparent contradiction with its reported inducibility mediated by LMP1 , taking into account that [NF-kappa B] was still *inducible* by or PMA and ionomycin . Positive_regulation NFKB1 TNF 21541574 407735 These results are in contrast to those reported for the murine p53 gene , whose promoter is *induced* by through activation of the [NF-kappa B] transcription factor . Positive_regulation NFKB1 TNF 21601601 2464267 TAK1 mediated cancer suppression is exerted through activating [NF-kappaB] in *response* to and through preventing Caspase-3 dependent hepatocyte and cholangiocyte apoptosis . Positive_regulation NFKB1 TNF 2176217 146958 Both the types A and B receptors mediated *induced* activation of the transcription factor [NF-kappa B] . Positive_regulation NFKB1 TNF 21826987 2463244 [ Effect of heat shock protein 90 inhibitor 17-dimethylamino-ethylaminogeldanamycin on TNfalpha mediated apoptosis and *induced* [NF-kappaB] activation ] . Positive_regulation NFKB1 TNF 21826987 2463273 17DMAG sensitized cervical cancer cells HeLa and ovarian cancer cells SKOV3 to TNFalpha induced cell death in a dose dependent manner , which was accompanied with degradation of RIP and Ikappakappabeta , and consequent blockage of *induced* [NFkappaB] activation . Positive_regulation NFKB1 TNF 21826987 2463275 17DMAG sensitizes cancer cells to TNFalpha mediated apoptosis through blockage of *induced* [NF-kappaB] activation , and disabling this survival signal with 17DMAG followed by TNF treatment could be an effective new therapeutic strategy for improving the anti-cancer value of TNFalpha . Positive_regulation NFKB1 TNF 22339724 2560753 Results indicate that these Hb solutions have different effects on stabilization and nuclear translocation of hypoxia-inducible factor (HIF)-1 alpha , induction of the erythropoietin (EPO) gene , *activation* of [nuclear factor (NF)-kappa B] , and expression of the anti-erythropoietic and transforming growth factor-beta 1 . Positive_regulation NFKB1 TNF 2279003 147439 Additionally , our data show that both dsRNA and LPS , as well as itself , rapidly *induce* [nuclear factor-kappa B (NF-kappa B)] , a DNA binding protein implicated in regulation of gene expression . Positive_regulation NFKB1 TNF 22911724 2648575 BME also attenuated induced *activation* of [NFkappaB] in differentiating preadipocytes and partially restored TNFalpha mediated suppression on adipogenesis . Positive_regulation NFKB1 TNF 22911724 2648579 Using a non-adipogenic HEK293 cell line transfected with luciferase reporter genes , we demonstrated that BME reduced basal and *induced* [NFkappaB] activity and increased basal and ciglitazone induced PPARgamma activity ; Positive_regulation NFKB1 TNF 23174100 2700539 Our results showed that TNF-alpha treatment increased Bcl-2 mRNA and protein levels in breast cancer cells , suggesting that Bcl-2 is directly regulated by [nuclear factor-kappaB (NF-kappaB)] in *response* to . Positive_regulation NFKB1 TNF 23174100 2700549 Silencing of sClu in MDA-MB-231/sClu siRNA cells abrogated mediated [NF-kappaB] *activation* and Bcl-2 overexpression , and rendered the MDA-MB-231/sClu siRNA cells significantly more sensitive to TNF-alpha mediated apoptosis than the parental cells . Positive_regulation NFKB1 TNF 23527709 2762039 Therefore , CD1d associated abnormalities of innate immune responses and production in splenic tissue may *contribute* to [NFkB] activation and cardiac dysfunction in type 2 diabetes . Positive_regulation NFKB1 TNF 23734186 2796957 This increased secretion of and IL-6 and *activation* of [NF-kB] , ERK , and JNK was significantly inhibited by the addition of either mannan or mannose . Positive_regulation NFKB1 TNF 24020126 2837287 In this study , we first examined the effect of resveratrol on endogenous and *induced* [NF-kappaB] activation , and found that resveratrol suppressed NF-kappaB activation in a dose dependent manner . Positive_regulation NFKB1 TNF 24239949 2897729 TAX1BP1 recruits A20 to the ubiquitinated signaling proteins TRAF6 and RIP1 , leading to their A20 mediated deubiquitination and the disruption of IL-1 induced and *induced* [NF-kappaB] signaling , respectively . Positive_regulation NFKB1 TNF 25204148 2958122 In the investigations of cell based in vitro assays of extracts , we found that both ethyl acetate extract and methanol extract of Lycii Cortex inhibited the induced *activation* of [NF-kappaB] . Positive_regulation NFKB1 TNF 25204148 2958124 Four phenolic amides showed differently inhibitory activities on *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 2809216 121402 In this report , we show that *activates* [NF-kappa B] and the human immunodeficiency virus enhancer in the Jurkat T leukemia but does not stimulate the IL-2R alpha enhancer . Positive_regulation NFKB1 TNF 7488149 332120 Cu2+ was found to inhibit the activation of [NF kappa B] *induced* by , TPA , or H2O2 . Positive_regulation NFKB1 TNF 7523113 272177 Whereas transcription factor [NF-kappa B] was readily *activated* by , activation was not induced by triggering APO-1/Fas . Positive_regulation NFKB1 TNF 7532017 286143 Only , LT , and IL-1 *activated* [NF-kappa B] . Positive_regulation NFKB1 TNF 7532017 286147 Since interferons have been shown to induce TNF receptors and potentiate TNF mediated cellular responses , we also measured the effect of interferons on *induced* activation of [NF-kappa B] . Positive_regulation NFKB1 TNF 7532017 286149 Under our conditions , all three IFNs potentiated the cytotoxic effects of TNF but had no effect on the *dependent* [NF-kappa B] activation . Positive_regulation NFKB1 TNF 7534663 296995 Gel-shift analyses demonstrated dose dependent inhibition of *induced* [NF-kappa B] mobilization by aspirin at concentrations ranging from 1 to 10 mmol/L. Induction of VCAM-1 and E-selectin surface expression by TNF was dose-dependently reduced by aspirin over the same range , while induction of intercellular adhesion molecule-1 ( ICAM-1 ) was hardly affected . Positive_regulation NFKB1 TNF 7540278 307216 Interestingly , exposure of MCF-Fas cells to anti-Fas or TNF induced activation of phospholipase A2 (PLA2) , while only *activated* [NF-kappa B] . Positive_regulation NFKB1 TNF 7541425 310491 Gelshift analysis demonstrated inhibition of *induced* [nuclear factor-kappa B (NF-kappa B)] mobilization by HMA . Positive_regulation NFKB1 TNF 7541425 310499 Our data suggest that specific phosphorylation following protein tyrosine kinase activation may be required for [NF-kappa B] mobilization and *induction* of VCAM-1 and ELAM-1 by . Positive_regulation NFKB1 TNF 7543732 314375 Although apigenin did not inhibit *induced* nuclear translocation of [NF-kappa B] ( p50 ( NFKB1 ) /p65 ( RelA ) ) we found this flavonoid did inhibit TNF-alpha induced beta-galactosidase activity in SW480 cells stably transfected with a beta-galactosidase reporter construct driven by four NF-kappa B elements , suggesting an action on NF-kappa B transcriptional activation . Positive_regulation NFKB1 TNF 7544915 318439 TRAF2 mediated *activation* of [NF-kappa B] by receptor 2 and CD40 . Positive_regulation NFKB1 TNF 7559390 328008 activates the stress activated protein kinases ( SAPKs , also known as Jun nuclear kinases or JNKs ) resulting in the stimulation of AP-1 dependent gene transcription and *induces* the translocation of [NF kappa B] to the nucleus resulting in the stimulation of NF kappa B-dependent gene transcription . Positive_regulation NFKB1 TNF 7559390 328010 also potently *stimulates* [NF-kappa B] DNA binding activity and transcriptional activity , but these effects are not mimicked by addition of C2-ceramide or sphingomyelinase to intact cells . Positive_regulation NFKB1 TNF 7569975 328869 Stimulation by *causes* the release of [NF-kappa B] from I kappa B alpha . Positive_regulation NFKB1 TNF 7585518 329774 ET-18-OCH3 did not inhibit [NF-kappa B] *activation* by either or IL-1 alpha , indicating that there are multiple distinct signal transduction pathways leading to activation of NF-kappa B . Positive_regulation NFKB1 TNF 7589098 334007 IL-4 was also found partially to inhibit [NF kappa B] activity *induced* by and interleukin-1-beta (IL-1 beta) . Positive_regulation NFKB1 TNF 7594489 334761 The effect of LPS and is mediated by their ability to *induce* nuclear translocation of the DNA binding heterodimer [NF-kappa B] ( p50/p65 ) , which binds to a specific sequence in the HIV-long terminal repeat . Positive_regulation NFKB1 TNF 7622526 315881 Electrophoretic mobility shift assays demonstrated that *activation* of [NF-kappa B] by L-NMA , ox-LDL , and was attenuated by GSNO and SNP , but not by glutathione or cGMP analogues . Positive_regulation NFKB1 TNF 7636259 317443 Our studies indicate that MV , , or PIPC *induces* [NF-kappa B] ( p50 and p65 subunits ) binding to positive regulatory domain II in the glioma cell line . Positive_regulation NFKB1 TNF 7642536 317967 Here we examine the inductions of [NF-kappa B] in serum deprived and cycling cells in *response* to . Positive_regulation NFKB1 TNF 7642536 317971 These data reveal that [NF-kappa B] is rapidly *induced* by in both proliferating and arrested cells and suggest that distinct activation pathways can lead to cell cycle dependent or -independent induction of NF-kappa B . Positive_regulation NFKB1 TNF 7642544 317974 Inhibitors of phosphotyrosyl protein phosphatases , pervanadate and phenylarsine oxide , abrogate *induced* [nuclear factor kappa B (NF-kappa B)] nuclear translocation in transformed cell lines ( U-937 and Jurkat ) and primary fibroblasts ( MRC-5 and REF ) . Positive_regulation NFKB1 TNF 7642544 317976 Treatment of cells with pervanadate inhibited TNF induced I kappa B-alpha phosphorylation and degradation , whereas the serine protease inhibitors tosylphenylalanyl chloromethyl ketone and N alpha-p-tosyl-L-lysine chloromethyl ketone prevented *induced* I kappa B-alpha degradation and [NF-kappa B] nuclear translocation , but not the TNF induced phosphorylation of I kappa B-alpha . Positive_regulation NFKB1 TNF 7642556 317984 The results indicate that H2O2 activates ICAM-1 transcription through AP-1/Ets elements within the ICAM-1 promoter , which are distinct from [NF-kappa B-mediated] ICAM-1 expression *induced* by . Positive_regulation NFKB1 TNF 7704934 288462 TNF alpha induced sphingomyelin hydrolysis , PLC mediated PC hydrolysis , and DG kinase mediated PA formation or *induced* [NF-kappa B] activation and apoptosis are not inhibited by LSF . Positive_regulation NFKB1 TNF 7706285 297698 As the TNF gene has an NF kappa B binding motif , an autocrine loop involving *induction* of [NF kappa B] is therefore likely in these cells . Positive_regulation NFKB1 TNF 7737374 305531 *induced* the activation of a nuclear transcriptional factor , [NF-kappa B] , equally in both young and senescent cells , which indicates the lack of a defect in the early events of TNF signal transduction in senescent fibroblasts . Positive_regulation NFKB1 TNF 7758105 307584 Overexpression of TRADD leads to two major *induced* responses , apoptosis and activation of [NF-kappa B] . Positive_regulation NFKB1 TNF 7758105 307586 However , NF-kappa B activation by TRADD is not inhibited by crmA expression , demonstrating that the signaling pathways for induced cell death and [NF-kappa B] *activation* are distinct . Positive_regulation NFKB1 TNF 7759567 307807 *induced* [NF kappa B] was also inhibited by tepoxalin in HeLa cells , while relatively less marked inhibition was observed in Jurkat cells . Positive_regulation NFKB1 TNF 7841193 293989 Similarly , N-acetylcysteine only proved inhibitory in hydrogen peroxide and TNF treated Jurkat and failed to inhibit IL1 and *activated* [NF kappa B] in EL4 . NOB-1 and KB cells respectively . Positive_regulation NFKB1 TNF 7859743 295224 HIV-1 Tat potentiates *induced* [NF-kappa B] activation and cytotoxicity by altering the cellular redox state . Positive_regulation NFKB1 TNF 7859743 295226 *mediated* activation of [NF-kappa B] and cytotoxicity involves the intracellular formation of reactive oxygen intermediates . Positive_regulation NFKB1 TNF 7917514 269827 Secretion of IL-2 and TNF-alpha , surface expression of IL-2R , and DNA binding activity of [NF-kappa B] and AP-1 ( Fos/Jun ) complex in *response* to phorbol myristate acetate , , or immobilized antibodies to CD3 were monitored . Positive_regulation NFKB1 TNF 7929233 274331 The post-receptor binding events that culminate in dependent [NF-kappa B] *activation* are not understood . Positive_regulation NFKB1 TNF 7929233 274333 Overall , our results indicate that intermediates required for [NF-kappa B] *activation* by or ceramide are membrane bound , but the mechanism of activation by TNF is most likely different from that of ceramide . Positive_regulation NFKB1 TNF 7957109 278009 Micromolar amounts of the peptide Cbz-Ile-Glu ( O-t-Bu ) -Ala-leucinal ( PSI ) , a specific inhibitor of the chymotrypsin-like activity of the proteasome , prevented activation of [NF-kappa B] in *response* to and okadaic acid ( OA ) through inhibition of I kappa B-alpha degradation . Positive_regulation NFKB1 TNF 7964161 279446 Activation of both acid and neutral sphingomyelinases ( SMases ) has been suggested , and Schutz et al. proposed that the phosphatidylcholine-phospholipase C/acid SMase pathway is involved in induced [NF-kappa B] *activation* . Positive_regulation NFKB1 TNF 7964161 279452 However , our recent study showed that the [NF-kappa B] activation is *induced* by in fibroblasts from patients with type A Niemann-Pick disease , with acid SMase deficiency . Positive_regulation NFKB1 TNF 7964161 279460 This finding implies that acid SMase activity is not essential for the *activation* of [NF-kappa B] by at least in fibroblasts . Positive_regulation NFKB1 TNF 7981153 281391 Furthermore , activation of [NFkB] was also induced in NPD type A fibroblasts in *response* to IL-1 alpha and stimulation to a similar extent as in normal fibroblasts . Positive_regulation NFKB1 TNF 7982975 281861 Although J774 cells responded to exogenously added rTNF-alpha , but not to H2O2 , by activation of NF-kappa B , the recombinant mediated [NF-kappa B] *activation* was enhanced by simultaneous presence of H2O2 . Positive_regulation NFKB1 TNF 7989309 282745 These results , overall , suggest that although receptors are *essential* for induction of [NF-kappa B] , a small percentage is sufficient to fully transduce this signal . Positive_regulation NFKB1 TNF 8019435 262795 Both nitecapone and OR-1246 ( 10-300 microM ) inhibited [NF-kappa B] activation *induced* by in Jurkat T ( acute human leukemia ) cells . Positive_regulation NFKB1 TNF 8022202 263102 In haemopoietic cell lines , *induction* of [NF-kappa B] is mediated via the generation of reactive oxygen intermediates and by the activation of protein kinase C ( PKC ) . Positive_regulation NFKB1 TNF 8022202 263104 Raising glutathione levels with N-acetyl cysteine substantially reduced [NF-kappa B] *induction* by in two of four samples tested . Positive_regulation NFKB1 TNF 8022202 263106 However , the protein kinase inhibitor staurosporine inhibited *induction* of [NF-kappa B] in four of five samples , suggesting that staurosporine-sensitive protein kinases ( other than PKC ) are involved in the signalling pathway . Positive_regulation NFKB1 TNF 8022202 263108 Our results suggest that PKC independent pathways , including pathways sensitive to redox reagents , mediate the *induction* of [NF-kappa B] by in chronic B-leukaemia cells . Positive_regulation NFKB1 TNF 8043432 266855 The *induction* of [NF kappa B] by is mediated via a novel signalling pathway involving the generation of reactive oxidative intermediates . Positive_regulation NFKB1 TNF 8043432 266859 Here we have used an electrophoretic mobility shift assay to show that *induced* [NF kappa B] in malignant cells isolated from 3/3 HCL and 15/15 B-CLL patients . Positive_regulation NFKB1 TNF 8046241 267020 Unlike TNF-alpha mediated cytotoxicity , the induced *activation* of [NF-kappa B] was inhibited by antioxidants regardless whether adenosine and homocysteine were present or absent in the culture medium . Positive_regulation NFKB1 TNF 8046241 267022 In conclusion , a combination of adenosine and homocysteine selectively modulates TNF-alpha mediated cytotoxicity without changing the *induced* activation of [NF-kappa B] . Positive_regulation NFKB1 TNF 8051093 267599 In HeLa cells , *induced* [NF-kappa B] activity . Positive_regulation NFKB1 TNF 8051093 267607 Thus , we show that [NF-kappa B] activates p53 and that this activation is *inducible* by . Positive_regulation NFKB1 TNF 8061120 268534 *activates* [nuclear factor kappa B (NF-kappa B)] and TGF-beta 1 does not . Positive_regulation NFKB1 TNF 8074713 270569 In human astrocytoma and neuroblastoma cell lines and interleukin 1 beta (IL-1 beta) *induced* [NFKB] and an additional KB-specific protein of approximately 80 K to bind the HIV-1 enhancer . Positive_regulation NFKB1 TNF 8076691 270636 Bcl-2 protects from oxidative damage and apoptotic cell death without interfering with *activation* of [NF-kappa B] by . Positive_regulation NFKB1 TNF 8076691 270640 However , Bcl-2 had no effect on the *activation* of [NF-kappa B] by , even though it protected cells from TNF induced apoptosis . Positive_regulation NFKB1 TNF 8096091 214532 Phorbol ester and *induction* of nuclear [NF-kappa B] is associated with both the degradation of performed I kappa B alpha and the activation of I kappa B alpha gene expression . Positive_regulation NFKB1 TNF 8132572 251549 The participation of cell ceramide in *stimulated* [NF-kappa B] activation in Jurkat T cells and HL-60 cells was studied . Positive_regulation NFKB1 TNF 8132572 251551 readily *stimulated* [NF-kappa B] activity in both cell lines as assayed by electrophoretic mobility shift assay and the use of a human immunodeficiency virus-chloramphenicol acetyltransferase reporter construct . Positive_regulation NFKB1 TNF 8132572 251553 We conclude that *induced* [NF-kappa B] activation occurs in Jurkat and HL-60 cell lines that do not demonstrate an increase in TNF-alpha induced ceramide . Positive_regulation NFKB1 TNF 8132572 251557 Increasing ceramide levels by the addition of short chain ceramides or the use of a glucosylceramide synthase inhibitor can be dissociated from *activation* of [NF-kappa B] by . Positive_regulation NFKB1 TNF 8152812 253061 *Activation* of multiple [NF-kappa B/Rel] DNA binding complexes by . Positive_regulation NFKB1 TNF 8182064 256464 By using receptor blocking antibodies we found that both p60 and p80 forms of TNF receptors were functional for NBT reducing activity , but *dependent* [NF-kappa B] activation required only the p60 receptor . Positive_regulation NFKB1 TNF 8188652 256835 Various inhibitors of serine-like proteases are shown to block mediated [NF-kappa B] *activation* as well as the disappearance of I kappa B-alpha immunoreactivity in primary murine T lymphocytes and in various human leukemic cell lines . Positive_regulation NFKB1 TNF 8207213 261389 Recent studies demonstrate that the sphingomyelinase-ceramide pathway plays a potential role in the *activation* of [nuclear factor-kappa B (NF-kappa B)] by . Positive_regulation NFKB1 TNF 8253818 238390 Inability to induce NF-kappa B can not be due to a non-activatable system since [NF-kappa B] was strongly *activated* by in all the five primary cell types tested . Positive_regulation NFKB1 TNF 8253818 238392 Conversely cysteine , an antioxidant and precursor of the free radical scavenger , glutathione , inhibited the *induction* of [NF-kappa B] by in primary cells , and by okadaic acid or tumor necrosis factor in transformed cells . Positive_regulation NFKB1 TNF 8253818 238394 The *induction* of [NF-kappa B] by in primary cells suggests that this cytokine fulfills the requirement for oxidation , possibly by inducing the production of free radicals . Positive_regulation NFKB1 TNF 8264646 247042 In Hs294T cells , gel shift analyses indicate that IL-1 and *induce* [NF-kappa B] complex formation ; Positive_regulation NFKB1 TNF 8276464 247195 In addition , *induction* of [NF-kB] binding activity by the was accompanied by a decrease in nuclear factors that bind to the CRE II region . Positive_regulation NFKB1 TNF 8282539 240630 Our results indicate that the potentiating effect of forskolin ( 50 microM ) on TNF mediated MCF7 cell lysis did not involve a modulation in the *induced* activation of the nuclear factor [NF-kB] but was associated with an increase in the DNA fragmenting capacity of TNF as assessed by agarose gel electrophoresis of target cell DNA . Positive_regulation NFKB1 TNF 8283141 247455 Both and LPS *activated* the same [NF-kappa B] nuclear complexes , composed of the p50 and p65 subunits . Positive_regulation NFKB1 TNF 8283141 247457 However , PDTC had a smaller inhibitory effect on LPS induced NF-kappa B activation and H-2 antigen expression , suggesting that and LPS *activate* [NF-kappa B] by somewhat different pathways . Positive_regulation NFKB1 TNF 8298498 240955 Vitamin E derivatives have been shown to inhibit *induced* [NF-kappa B] activation in human Jurkat T cells . Positive_regulation NFKB1 TNF 8344250 226433 This depletion of the mitochondrial oxidative metabolism resulted in resistance towards TNF cytotoxicity , as well as in inhibition of [NF kappa B] activation and interleukin-6 gene *induction* by . Positive_regulation NFKB1 TNF 8349660 227104 In this cell line , *caused* potent activation of [nuclear factor-kappa B (NF-kappa B)] and exerted potent cytostatic/cytocidal activity . Positive_regulation NFKB1 TNF 8349660 227106 C2-ceramide , however , enhanced activation of [NF-kappa B] in *response* to with peak effects observed at a concentration of C2-ceramide of 5 microM . Positive_regulation NFKB1 TNF 8376408 229929 As shown previously , ( 1 nM ) *induced* a marked increase in nuclear [NF-kappa B] binding in human leukemia ( HL-60 ) cells within 5 min , and elevated binding was detected for as long as 1 h. Addition of a maximally effective concentration of sphingomyelinase , 0.1 units . ml-1 , induced a 50 % reduction in sphingomyelin content by 5 min from a basal level of 560 pmol.10 ( 6 ) cells-1 and a quantitative increase in ceramide levels from 89 pmol.10 ( 6 ) cells-1 . Positive_regulation NFKB1 TNF 8409402 233341 Moreover , *induced* activation of [NF-kappa B-like] transcription factors was unaffected by altered levels of hsp70 as tested by electrophoretic mobility shift assay . Positive_regulation NFKB1 TNF 8432991 212948 In addition , [NF-kappa B] binding activity was *induced* by these agents as was the secretion of . Positive_regulation NFKB1 TNF 8495426 219513 At the biochemical level , staurosporine increased the *mediated* activation of phospholipases C and D and the transcription factor [NF-kappa B] in L929 cells . Positive_regulation NFKB1 TNF 8521084 336406 However several questions regarding the molecular mechanisms involved in particular steps of these cascades remain largely unresolved : how and at which subcellular level , do the cells produce these reactive oxygen intermediates that will contribute to [NF kappa B] activation in *response* to IL-1 or ? Positive_regulation NFKB1 TNF 8554902 337181 DFO also protected against PMA induced [NF-kappa B] activation as well as induced HIV-1 *activation* . Positive_regulation NFKB1 TNF 8555009 340106 TPCK , a I kappa-B alpha protease inhibitor , was able to virtually abolish UV-induced TNF release , indicating that UV-induced release *requires* [NF-kappa B] activation . Positive_regulation NFKB1 TNF 8565075 349082 can induce apoptosis and *activate* [NF-kappa B] through signaling cascades emanating from TNF receptor 1 (TNFR1) . Positive_regulation NFKB1 TNF 8565075 349087 A TRAF2 mutant lacking its N-terminal RING finger domain is a dominant negative inhibitor of mediated [NF-kappa B] *activation* , but does not affect TNF induced apoptosis . Positive_regulation NFKB1 TNF 8580820 342318 *induction* of [NF-kappa B] was abolished by antioxidants , suggesting involvement of the free radical pathway . Positive_regulation NFKB1 TNF 8590321 342397 Upregulation of [NF-kappa B-dependent] gene expression *mediated* by the p75 receptor . Positive_regulation NFKB1 TNF 8597871 342619 Furthermore , when equitoxic concentrations of anti-Fas antibody and TNF were applied , *triggered* a stronger [NF-kappa B] response . Positive_regulation NFKB1 TNF 8612692 353280 *induces* a rapid and transient activation of [NF-kappaB] in WEHI 164 cells which is followed by a second , long lasting phase in which the amount of NF-kappaB complex in the nucleus remains at about 50 % of maximum . Positive_regulation NFKB1 TNF 8612692 353284 Calphostin C , on the other hand , can block the *activation* of [NF-kappaB] by , also blocking its proteolytic degradation . Positive_regulation NFKB1 TNF 8621670 354294 Additionally , one of the TRADD mutants that fails to activate NF-kappaB was found to act as dominant negative mutant capable of preventing *induction* of [NF-kappaB] by . Positive_regulation NFKB1 TNF 8621670 354298 Such observations provide evidence that TRADD performs an obligate role in *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 8626413 355701 Furthermore , *activation* of [NF-kappaB] by also results in repression of PR , while PR is able to repress tumor necrosis factor-alpha induced NF-kappaB activity . Positive_regulation NFKB1 TNF 8627768 356047 The first was to abruptly terminate *induced* [NF-kappaB] binding to the enhancer sequences in U1 monocytic cells , using a short pulse of exogenous tumor necrosis factor . Positive_regulation NFKB1 TNF 8647884 358686 We show that ER overload mediated NF-kappaB activation but not *stimulated* [NF-kappaB] induction can be inhibited by the intracellular Ca2+ chelator TMB-8 . Positive_regulation NFKB1 TNF 8655581 366980 We report here that both kappa B-dependent transactivation of a reporter gene and [NF-kappa B] activation in *response* to ( TNF alpha ) or H2O2 treatments are deficient in human T47D cell transfectants that overexpress seleno-glutathione peroxidase ( GSHPx ) . Positive_regulation NFKB1 TNF 8662702 367190 additionally *caused* rapid p38 and JNK-1 mitogen activated protein kinase activation and efficient [NF-kappaB] translocation , which could not be achieved even by high levels of ceramide . Positive_regulation NFKB1 TNF 8662753 367251 MEK kinase is involved in alpha *induced* [NF-kappaB] activation and degradation of IkappaB-alpha . Positive_regulation NFKB1 TNF 8662753 367255 These results suggest that MEK kinase is a signal mediator involved in *induced* [NF-kappaB] activation and that the activation of NF-kappaB by MEK kinase is regulated through the degradation of IkappaB-alpha . Positive_regulation NFKB1 TNF 8663191 368411 We conclude that *causes* persistent activation of [NF-kappaB] in human EC and that this may result from sustained reductions in IkappaB-beta levels . Positive_regulation NFKB1 TNF 8683130 370272 Since ceramide has been shown to play a role in *mediated* activation of [nuclear factor-kappa B (NF-kappa B)] , we examined the effect of SR33557 on this early cellular response of TNF . Positive_regulation NFKB1 TNF 8683130 370274 Surprisingly , this inhibitor of ceramide production was found to have no effect on mediated [NF-kappa B] *activation* , thus suggesting that SR33557-sensitive acidic SMase is not involved in this process . Positive_regulation NFKB1 TNF 8697149 371012 Furthermore , *activated* the nuclear transcriptional factor [NF-kappa B] in both cell types , whereas anti-Fas had no effect . Positive_regulation NFKB1 TNF 8699854 343305 also *induces* expression of human immunodeficiency virus ( HIV ) through activation of the transcription factor [NF-kappa B] , which binds to the viral long terminal repeat ( LTR ) . Positive_regulation NFKB1 TNF 8710854 376584 TRAF2 is required for CD40- and mediated *activation* of the transcription factor [NF-kappa B] . Positive_regulation NFKB1 TNF 8724035 373769 An enhanced [nuclear factor (NF)-kappa B] activation in *response* to has been observed in stably tat transfected cells . Positive_regulation NFKB1 TNF 8724035 373773 Therefore , the possible association of a Tat autocrinous loop with the enhanced [NF-kappa B-binding] activity *induced* by in Tat producing cells was studied by anti-Tat antibody blocking experiments . Positive_regulation NFKB1 TNF 8724035 373775 Permanently tat transfected Jurkat cells , maintained either in the presence or absence of anti-Tat antibody , were studied for the presence of *induced* [NF-kappa B-binding] activity ( quantified by electrophoretic mobility shift assays ) and the presence of cell-surface bound Tat ( determined by flow cytometry and confocal microscopy of anti-Tat immunofluorescence stained cell preparations . Positive_regulation NFKB1 TNF 8724035 373777 The enhanced production of *induced* [NF-kappa B] binding activity exhibited by tat transfected Jurkat cells was completely abolished in cell cultures maintained in the presence of anti-Tat antibody , thus indicating that the increased TNF-alpha induced NF-kappa B binding activity observed in Jurkat-tat cells was dependent on the presence of Tat protein in an antibody-accessible location . Positive_regulation NFKB1 TNF 8760145 378030 *increased* [nuclear factor (NF)-kappa B-DNA] binding , an effect blocked by pretreatment with NAC . Positive_regulation NFKB1 TNF 8772190 379410 Two distinct intracellular Ca2+ chelators and a panel of structurally unrelated antioxidants prevented NF-kappaB activation by various ER stress eliciting agents , whereas only antioxidants but not the Ca2+ chelators prevented [NF-kappaB] *activation* by the inflammatory cytokine . Positive_regulation NFKB1 TNF 8790599 291138 The mechanism of inhibitory action of PTX on virus replication and NF-kappa B-induced transactivation of HIV-1 gene expression has been elucidated as due to blocking PKC dependent PMA- or *induced* activation of [NF-kappa B] in Jurkat and 293-27-2 cells . Positive_regulation NFKB1 TNF 8798772 381881 and lymphotoxin alpha ( LTalpha , originally TNFbeta ) are potent [nuclear factor kappaB (NFkappaB)] *activators* in various cell types . Positive_regulation NFKB1 TNF 8799159 381940 Our results show that the *activation* of [NF-kappa B] by is completely blocked by CAPE in a dose- and time dependent manner . Positive_regulation NFKB1 TNF 8805640 382275 Overall , our results clearly demonstrate that the *activation* of [NF-kappa B] and cytotoxicity by is differentially regulated through the p60 receptor . Positive_regulation NFKB1 TNF 8822344 384838 HTLV-I tax protein and *induced* activation of [NF-kappa B] in apoptotic MC3T3-E1 cells . Positive_regulation NFKB1 TNF 8830655 385502 We found that binding of [NFkappaB] is strongly *induced* in mesangial cells by both IL-1beta and . Positive_regulation NFKB1 TNF 8831497 385729 However , the intracellular signaling pathways that activate endothelial [NF-kappa B] and JNK in *induced* responses are unknown . Positive_regulation NFKB1 TNF 8832978 385884 Our data suggest that *induces* expression of proinflammatory cytokines such as IL-8 and MCP-1 through generation of reactive oxygen intermediates and subsequent activation of [NF-kappa B] in human synovial cells , and the antioxidants may inhibit , at least in part , the activation of NF-kappa B by TNF-alpha . Positive_regulation NFKB1 TNF 8844707 387568 *activated* [nuclear factor kappa B (NF kappa B)] in HBMEC . Positive_regulation NFKB1 TNF 8849369 359028 To examine whether [nuclear factor kappaB (NF-kappaB)] is activated in cultured synovial cells in *response* to and to investigate the correlation between NF-kappaB activation and synovial cell proliferation . Positive_regulation NFKB1 TNF 8849369 359032 Stimulation of synovial cells with *activated* [NF-kappaB] and subsequent transcription of several genes . Positive_regulation NFKB1 TNF 8849369 359034 Treatment of synovial cells with N-acetyl-L-cysteine (NAC) , an antioxidant agent , inhibited *induced* [NF-kappaB] activation and transcription . Positive_regulation NFKB1 TNF 8852698 387842 Analysis of DNA binding revealed that [NF-kappa B] activation in *response* to was significantly inhibited under these conditions . Positive_regulation NFKB1 TNF 8863511 388842 Here , we describe that both IL-1 beta and *activate* the transcription factor [nuclear factor-kappa B (NF-kappa B)] via production of reactive oxygen intermediates resulting in ACT expression . Positive_regulation NFKB1 TNF 8864119 388932 The *activation* of the transcription factor [nuclear factor-kappa B (NF-kappaB)] by , ionizing radiation , or daunorubicin ( a cancer chemotherapeutic compound ) , was found to protect from cell killing . Positive_regulation NFKB1 TNF 8870842 389483 HIV type 1 glycoprotein 120 amplifies induced [NF-kappa B] *activation* in Jurkat cells . Positive_regulation NFKB1 TNF 8870842 389485 In CD4 positive Jurkat cells , gp120 potentiates *induced* [NF-kappa B] activation . Positive_regulation NFKB1 TNF 8870842 389487 *mediated* activation of [NF-kappa B] is known to involve the intracellular formation of reactive oxygen intermediates ( ROIs ) . Positive_regulation NFKB1 TNF 8870842 389489 In contrast , in the p56lck-deficient J.CaM1.6 T cell line , a derivative of the Jurkat cell line , gp120 was unable to stimulate hydrogen peroxide , to decrease the ratio of GSH to GSSG , and has no effect on *induced* [NF-kappa B] activation . Positive_regulation NFKB1 TNF 8870842 389491 Taken together , our data suggest that gp120 potentiates *induced* [NF-kappa B] activation by stimulating a signal pathway that involves p56lck and the increased formation of reactive oxygen intermediates such as H2O2 . Positive_regulation NFKB1 TNF 8873967 389862 These results indicate that nuclear translocation and *activation* of [NF-kappa B] through generated ceramide may be one important apoptotic signaling pathway in MC3T3-E1 cells . Positive_regulation NFKB1 TNF 8900181 393448 Electrophoretic mobility shift assays with nuclear extracts of A3 cells showed that stimulation with ATRA and for more than 16 h *resulted* in enhanced [NF-kappaB] binding compared to that induced by TNF-alpha alone . Positive_regulation NFKB1 TNF 8940176 399126 and interferon-gamma *induced* [NF-kappaB] ( p50/p65 ) and STAT-1 , respectively , as assessed by gel shift assays . Positive_regulation NFKB1 TNF 8943045 399478 The association of TRADD , a 34-kDa cytoplasmic protein containing a C-terminal death domain , with aggregated through their respective death domains *leads* to [NF-kappa B] activation and programmed cell death . Positive_regulation NFKB1 TNF 8947041 400454 We have created mutant cell lines that are unable to activate [NF-kappaB] in *response* to . Positive_regulation NFKB1 TNF 8995233 409350 Our results demonstrated that the mutated IkappaB alpha was stably expressed in the transfected MCF7 cells and blocked the *induced* [NF-kappaB] nuclear translocation . Positive_regulation NFKB1 TNF 9013701 411791 In a stable mouse L cell clone , L-15 , [NF-kappaB] DNA binding activity *induced* by uv-C ( 254 nm ) but not by or 12-O-tetra-decanoylphorbol-13-acetate ( TPA ) correlated with the stimulation of HIV-LTR directed chloramphenicol acetyltransferase (CAT) activity ; Positive_regulation NFKB1 TNF 9038369 415551 Moreover this glucocorticoid did not suppress the *induced* increase of [NF-kappaB] binding activity . Positive_regulation NFKB1 TNF 9042860 416132 We also show that *activation* of [NF-kappaB] by depends on CDC42 and RhoA , but not Rac-1 proteins , because this activity is drastically inhibited by their respective dominant negative mutants . Positive_regulation NFKB1 TNF 9053449 417233 Involvement of Egr-1/RelA synergy in distinguishing T cell activation from *induced* [NF-kappa B1] transcription . Positive_regulation NFKB1 TNF 9065470 418210 The activation of NF-kappaB by fMLF appeared to be cell-specific and different from the *activation* of [NF-kappaB] by . Positive_regulation NFKB1 TNF 9099747 422876 The sphingomyelin pathway is thought to mediate the *induced* activation of [NF-kappaB] by its second messenger ceramide . Positive_regulation NFKB1 TNF 9099747 422878 Here we present experimental evidence that acid sphingomyelinase is not involved in the *induced* activation of [NF-kappaB] . Positive_regulation NFKB1 TNF 9110146 424994 Iron chelation decreases human immunodeficiency virus-1 Tat potentiated *induced* [NF-kappa B] activation in Jurkat cells . Positive_regulation NFKB1 TNF 9110146 424997 mediated *activation* of [NF-kappa B] is known to involve the intracellular formation of reactive oxygen intermediates ( ROIs ) . Positive_regulation NFKB1 TNF 9110146 424999 We recently demonstrated that HIV-1 Tat protein potentiates *induced* [NF-kappa B] activation by downregulation of manganese dependent superoxide dismutase ( MnSOD ) , shifting the cellular redox state towards pro-oxidative conditions . Positive_regulation NFKB1 TNF 9110146 425001 This study shows that treatment of Jurkat cells with iron chelator deferoxamine ( DFO ) strongly decreases HIV-1 Tat potentiated *induced* [NF-kappa B] activation but does not modify NF-kappa B activation by TNF-alpha . Positive_regulation NFKB1 TNF 9110146 425003 The ability of iron chelators to reduce Tat potentiated *induced* [NF-kappa B] binding activity suggests that iron and intracellular hydroxyl radicals ( OH. ) are required for Tat effect . Positive_regulation NFKB1 TNF 9110146 425005 markedly enhanced *induced* [NF-kappa B] activation in a dose dependent manner while was not sufficient to trigger activation of NF-kappa B by itself . Positive_regulation NFKB1 TNF 9110146 425007 in the presence of iron ions play a major role in HIV-1 Tat enhancement of *induced* [NF-kappa B] activation and that iron chelation may protect Jurkat T cells , at least in part , against oxidative stress induced by Tat . Positive_regulation NFKB1 TNF 9115810 419247 Ascorbate and AZT also had no effect on [NF-kappa B] *activation* following or PMA induced stimulation of U1 promonocytic cells . Positive_regulation NFKB1 TNF 9122255 423975 Contrary to the results in Jurkat cells , PDTC did not inhibit *induced* [NF kappaB] activation in astrocytes ; Positive_regulation NFKB1 TNF 9126284 426479 This pretreatment also inhibited activation of [NF-kappa B] in *response* to in lymphoblastoid J.Jhan5-1 cells . Positive_regulation NFKB1 TNF 9139689 428181 and hydrogen peroxide , in contrast , *led* to [NF-kappaB] activation but only modestly stimulated p38 . Positive_regulation NFKB1 TNF 9149909 430096 Secreted *mediated* the enhancement of [nuclear factor kappa B (NF-kappa B)] and activator protein-1 (AP-1) binding activity ; Positive_regulation NFKB1 TNF 9153285 431292 *initiates* [NF-kappaB] nuclear translocation by causing dissociation of the inhibitory protein I-kappaBalpha from NF-kappaB and rapid degradation of I-kappaBalpha . Positive_regulation NFKB1 TNF 9168973 432690 Moreover , we have shown that while an intracellular calcium chelator BAPTA/AM was able to inhibit both SPP- and TG-induced NF-kappa B activation , it had no effect on *induced* [NF-kappa B] activation . Positive_regulation NFKB1 TNF 9176246 433697 The GR antagonist RU-486 inhibited the repressive effect of Dex on *induced* [NF-kappa B] activity by 81 % but only counteracted the repressive effect of Dex on TPA induced AP-1 activity by 43 % . Positive_regulation NFKB1 TNF 9185524 436712 The constitutive and *induced* [NF-kappaB/Rel] complexes were identical and were composed mainly of p50 and c-Rel proteins . Positive_regulation NFKB1 TNF 9185524 436715 These results indicate that the aberrant , constitutive GM-CSF gene activation in JMML is maintained by mediated *activation* of [NF-kappaB/Rel] proteins . Positive_regulation NFKB1 TNF 9195956 438330 ( vi ) Ceramide generation in response to Fas activation was inhibited by N-acetyltyrosinylvalinylalanylaspartyl chloromethyl ketone , a peptide inhibitor of interleukin-1beta converting enzyme-like proteases , whereas *induced* [NF-kappaB] activation was unaffected by the inhibitor . Positive_regulation NFKB1 TNF 9199898 439032 SAC consistently exhibited a dose dependent inhibition of [NF-kappa B] activation *induced* by both and H2O2 . Positive_regulation NFKB1 TNF 9224625 441842 AFR behaves like ascorbate , while DHA and ascorbate phosphate do not affect mediated [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 9237663 445678 Inhibition of protein tyrosine phosphatases blocks *induced* growth modulation and [NF-kappaB] activation , both mediated primarily through the p60 TNF receptor . Positive_regulation NFKB1 TNF 9237663 445681 Taken together , these results suggest that protein tyrosine phosphatases play an essential role in phosphorylation of the cytoplasmic domain of the TNF receptor and in regulation of the receptor associated kinase , and this in turn may play a role in *mediated* growth modulation and [NF-kappaB] activation . Positive_regulation NFKB1 TNF 9244310 446242 *Activation* of the transcription factor [NF-kappaB] by and interleukin-1 (IL-1) requires the NF-kappaB inducing kinase (NIK) . Positive_regulation NFKB1 TNF 9268159 449763 N-Acetylcysteine (NAC) , pyrrolidinedithiocarbamate ( PDTC ) , and Trimidox ( TD ) at various concentrations inhibited *induced* [NF-kappaB] binding in Jurkat cells . Positive_regulation NFKB1 TNF 9268159 449765 On the other hand , iron chelators desferrioxamine , pyridoxal isonicotinoyl hydrazone (PIH) , and salicylaldehyde isonicotinoyl hydrazone ( SIH ) showed no inhibition of *induced* [NF-kappaB] DNA binding activity . Positive_regulation NFKB1 TNF 9275204 450668 *induced* activation of the transcription factor [NF-kappaB] and the c-jun N-terminal kinase ( JNK/SAPK ) requires TNF receptor associated factor 2 (TRAF2) . Positive_regulation NFKB1 TNF 9277478 450781 Electrophoretic mobility-shift assays of HUVEC nuclear proteins revealed a decrease in *stimulated* [nuclear factor-kappa B (NF-kappa B)] activation after pretreatment of HUVEC with TCP succinate but not with TCP , TCP acetate , or succinate alone . Positive_regulation NFKB1 TNF 9294162 452903 In contrast to wild-type c-IAP2 , a mutant lacking the C-terminal RING domain inhibits [NF-kappaB] *induction* by and enhances TNF killing . Positive_regulation NFKB1 TNF 9299419 453451 Glutathione regulation of *induced* [NF-kappa B] activation in skeletal muscle derived L6 cells . Positive_regulation NFKB1 TNF 9299419 453457 Results from GSSG reductase inhibited cells suggest that GSSG may participate in , but is not required for , *induced* [NF-kappa B] activation . Positive_regulation NFKB1 TNF 9312187 455484 *potentiated* [NF-kappaB] translocation into the nucleus and stimulated apoptosis in isolated acini while not affecting LDH release . Positive_regulation NFKB1 TNF 9317150 456275 Transient overexpression of the TRAF2 adaptor protein can activate NF-kappaB and endogenous JNK , whereas N-terminal truncated TRAF2 protein blocks *induced* [NF-kappa B] and JNK activation as well as E-selectin promoter-reporter gene transcription . Positive_regulation NFKB1 TNF 9317150 456292 These data suggest that *activates* parallel [TRAF-NF-kappa B] and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways to initiate E-selectin transcription . Positive_regulation NFKB1 TNF 9325328 456919 Lipid peroxidation is involved in the *activation* of [NF-kappaB] by but not interleukin-1 in the human endothelial cell line ECV304 . Positive_regulation NFKB1 TNF 9325328 456922 Here we have investigated the effect of a range of putative antioxidants on [NF-kappaB] *activation* by interleukin-1 and as well as the ability of H2O2 to activate NF-kappaB in primary human umbilical vein endothelial cells and the transformed human endothelial cell line ECV304 . Positive_regulation NFKB1 TNF 9325328 456977 Finally , butylated hydroxyanisole , which inhibits lipid peroxidation but has no iron chelating properties , inhibited [NF-kappaB] *activation* by but not interleukin-1 . Positive_regulation NFKB1 TNF 9325328 456980 Furthermore , and interleukin-1 *activate* [NF-kappaB] through different mechanisms in ECV304 cells , with the tumor necrosis factor pathway involving iron catalyzed lipid peroxidation . Positive_regulation NFKB1 TNF 9332715 457650 The oxidative stress responsive transcription factor [nuclear factor-kappa B (NF-kappa B)] consists of a p50 ( 50 kDa ) and p65/RelA ( 65 kDa ) component and can be *activated* in vitro by , IL1 beta , hydrogen peroxide and oxygen radicals . Positive_regulation NFKB1 TNF 9341756 458756 Recent studies from our laboratory have indicated that protein tyrosine phosphatase ( PTPase ) inhibitors can down-modulate the *mediated* activation of the nuclear transcription factor [NF-kappa B] in ML-1a , a monocytic cell line ( Singh and Aggarwal , J. Biol. Chem. 1995 : 270 : 10631 ) . Positive_regulation NFKB1 TNF 9341756 458759 Besides PAO , other inhibitors of PTPase , including pervanadate and diamide , also blocked *dependent* [NF-kappa B] activation and induction of all the three adhesion proteins . Positive_regulation NFKB1 TNF 9343439 459032 However , since *activation* of [NF-kappaB] by is often transient and would not activate long-term kappaB dependent transcription effectively , we explored the effects of IFN-gamma on TNF-alpha induced NF-kappaB activity . Positive_regulation NFKB1 TNF 9343439 459036 IFN-gamma , which typically does not activate NF-kappaB , synergistically enhanced *induced* [NF-kappaB] nuclear translocation via a mechanism that involves the induced degradation of I kappaBbeta and that apparently requires tyrosine kinase activity in preneuronal cells but not in endothelial cells . Positive_regulation NFKB1 TNF 9346915 459568 In this cell line ( EL4D6/76 ) , *induced* ligand/receptor internalization , [NFkappaB] nuclear translocation , IL-2 production , and the activation of neutral (N)-SMase and acid ( A ) -SMase . Positive_regulation NFKB1 TNF 9351451 461145 In electrophoretic mobility shift assays , *activated* [nuclear factor-kappa B (NF-kappa B)] with a peak at approximately 3 hours , whereas pulsatile stretch showed sustained activation during stimulation for up to 24 hours . Positive_regulation NFKB1 TNF 9351830 466077 Microinjection of the inhibitory peptides into stimulated cells abolished [NF-kappa B] activation in *response* to and the consequent expression of E-selectin , an NF-kappa B-dependent cell-adhesion molecule . Positive_regulation NFKB1 TNF 9374527 465150 Despite *activation* of [nuclear factor-kappaB (NF-kappaB)] by , this transcription factor was not required for TNF induced transcription of gamma-GCS-HS as revealed by deletion constructs of the gamma-GCS-HS promoter subcloned in a chloramphenicol acetyltransferase reporter vector and transfected into HepG2 cells . Positive_regulation NFKB1 TNF 9383399 345225 Cell lines stably overexpressing the H2O2 degrading enzyme catalase were deficient in activating [NF-kappa B] in *response* to or okadaic acid . Positive_regulation NFKB1 TNF 9388244 466785 The induction of vascular cell adhesion molecule-1 ( VCAM-1 ) expression by *requires* the activation of [nuclear factor-kappaB (NF-kappaB)] via a process involving the phosphorylation and degradation of its cytoplasmic inhibitor , IkappaBalpha . Positive_regulation NFKB1 TNF 9388244 466791 *Activation* of [NF-kappaB] by occurred within 15 min and coincided with rapid degradation of IkappaBalpha . Positive_regulation NFKB1 TNF 9394802 468199 These data suggest that PAF , which is released immediately or shortly after LPS injection , *induces* the expression of through the activation of [NF-kappa B] . Positive_regulation NFKB1 TNF 9405407 469817 Finally , interference with GCKR expression impeded TRAF2- and *induced* SAPK activation but not that of [NF-kappaB] . Positive_regulation NFKB1 TNF 9417872 472286 Expression of bcl-2 did not impose a block to , or potentiate , signaling of I kappa B alpha degradation , nuclear import of the RelA p65 , or [NF-kappa B-dependent] *transactivation* . Positive_regulation NFKB1 TNF 9418855 480458 *Activation* of [NF-kappaB] by and IL-1 is initiated by the phosphorylation of the inhibitory subunit , IkappaB , which targets IkappaB for degradation and leads to the release of active NF-kappaB . Positive_regulation NFKB1 TNF 9418855 480462 The nonsteroidal anti-inflammatory drug sodium salicylate ( NaSal ) interferes with induced [NF-kappaB] *activation* by inhibiting phosphorylation and subsequent degradation of the IkappaB alpha protein . Positive_regulation NFKB1 TNF 9427646 481712 In addition , GFP-DeltaFADD did not interfere with mediated gene induction or with *activation* of [NF-kappaB] or Jun N-terminal kinase (JNK) , demonstrating that FADD is part of the TNFR60 initiated apoptotic pathway but does not play a role in TNFR60 mediated gene induction . Positive_regulation NFKB1 TNF 9430229 474415 The C-terminus of MyD88 interacts with the IL-1 receptor and blocks [NF-kappaB] activation *induced* by IL-1 , but not by . Positive_regulation NFKB1 TNF 9435375 474695 In TNF-alpha and GC target cell lines , it was found that : 1 ) TNF-alpha enhanced GR number in L-929 cells , and 2 ) by transfection of these cells with a reporter plasmid carrying the GR promoter , that TNF-alpha induced increase in GR is at the transcriptional level , 3 ) by electrophoretic mobility shift assay , using nuclear extracts of TNF-alpha ( 0.02 ng/ml ) or TNF-alpha plus DEX ( 10 nM ) stimulated L-929 cells , that cytokines can increase the binding of GR to GRE ( 45 min , 1.8 x ) , while the *induced* [NFkB] factor expression was not affected by GC . Positive_regulation NFKB1 TNF 9439980 475066 Curcumin inhibits IL1 alpha and *induction* of AP-1 and [NF-kB] DNA binding activity in bone marrow stromal cells . Positive_regulation NFKB1 TNF 9439980 475077 IL1 alpha and rapidly *induced* both AP-1 and [NF-kB] DNA binding activities in +/+ ( - ) 1.LDA11 stromal cells . Positive_regulation NFKB1 TNF 9439980 475084 These data suggest that inhibition of MCP-1/JE transcription by curcumin involves blocking of AP-1 and [NF-kB] *activation* by IL1 alpha or . Positive_regulation NFKB1 TNF 9442373 475191 We found that removal of the containing medium *causes* a rapid decrease in nuclear [NF-kappa B] . Positive_regulation NFKB1 TNF 9454839 484404 Furthermore , unlike TNF-alpha treatment , NGF treatment did not significantly activate JNK , although both and NGF *induced* nuclear translocation of [NF-kappaB] . Positive_regulation NFKB1 TNF 9458713 484607 In bovine aorta and bovine pulmonary artery endothelial cells , *activated* [nuclear factor (NF)-kappa B] . Positive_regulation NFKB1 TNF 9466577 485599 The activation of sphingomyelinase and the generation of ceramide has been proposed to mediate *induced* [nuclear factor (NF)-kappaB] activation through its second messenger ceramide . Positive_regulation NFKB1 TNF 9466577 485601 was shown to *activate* [NF-kappaB] ( p65 translocation and degradation of IkappaBalpha ) and the stress kinase pathway ( phosphorylation of ATF-2 , p38 , and c-jun ) . Positive_regulation NFKB1 TNF 9466577 485603 Thus , although *stimulates* the [NF-kappaB] and stress kinase pathways in HSF , these effects of TNF-alpha are not associated with sphingomyelinase turnover or induction of apoptosis . Positive_regulation NFKB1 TNF 9468519 486082 In gel mobility supershift assays , the antibodies to c-Fos or c-Jun inhibited the binding of *activated* nuclear [NF-kappaB] to the kappaL-kappaR , suggesting that both c-Fos and c-Jun interacted with NF-kappaB . Positive_regulation NFKB1 TNF 9479002 487177 [NF-kappaB] activation *induced* by , as detected by mobility shift assays or by transfection of kappaB-driven reporter genes , is impaired in African swine fever virus infected cells . Positive_regulation NFKB1 TNF 9486215 488326 By EMSA , TPA and *increased* nuclear [NF-kappa B] binding activity in temporally distinct patterns . Positive_regulation NFKB1 TNF 9486215 488328 PDTC decreased TPA- and *induced* [NF-kappa B] binding activity but did not limit their inhibition of SP-A and SP-B mRNAs . Positive_regulation NFKB1 TNF 9486659 488353 Furthermore , *induced* [NF-kappaB] DNA binding activity was inhibited in the population of endothelial cells expressing IkappaBdeltaN . Positive_regulation NFKB1 TNF 9497357 490360 Moreover , the activation of [nuclear factor kappaB (NFkappaB)] *induced* by extracellularly added H2O2 or was blocked by overproduction of Prx II . Positive_regulation NFKB1 TNF 9500555 490823 Transfection of a truncated Peg3 containing the TRAF2 interaction site , abolishes [NFkappaB] *activation* by TRAF2 and/or . Positive_regulation NFKB1 TNF 9501011 491004 We demonstrate that adenovirus mediated overexpression of I kappa B alpha , an inhibitor of [NF-kappa B] suppresses the expression of piap in *response* to suggesting that piap is one of the NF-kappa B regulated genes that operates to prevent programmed cell death of EC in inflammation . Positive_regulation NFKB1 TNF 9506462 491339 *dependent* activation of [NF-kappaB] could be blocked partially by both anti-p60 and anti-p80 , suggesting that TNF mediates its effect independently through the p60 and p80 receptors . Positive_regulation NFKB1 TNF 9506955 491503 Two closely related IkappaBalpha kinases as well as the upstream kinase , NIK , which integrates interleukin-1beta (IL-1beta)- and dependent *activation* of the transcription factor [NF-kappaB] have recently been described . Positive_regulation NFKB1 TNF 9520401 493504 A previously identified NF-kappaB inducing kinase (NIK) , which mediates [NF-kappaB] *activation* by and IL-1 , has been demonstrated to activate IKKalpha . Positive_regulation NFKB1 TNF 9520446 493641 A mutant form of IKK-alpha containing alanine at residue 176 can not be phosphorylated or activated by NIK and acts as a dominant negative inhibitor of interleukin 1- and *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 9528954 496222 These results strongly suggest that *increases* the IL-6 gene expression through the activation of [NF-kappaB] in the thyroid cells , and that antioxidants suppress the TNF-alpha dependent IL-6 expression by inhibiting the activation of the transcriptionally active NF-kappaB . Positive_regulation NFKB1 TNF 9529147 496491 The death domain kinase RIP mediates the *induced* [NF-kappaB] signal . Positive_regulation NFKB1 TNF 9548505 477737 Similar potentiation of *induced* [NF-kappaB] activity and E-selectin transcription by thrombin was observed in experiments utilizing luciferase reporter constructs expressed in bovine aortic EC . Positive_regulation NFKB1 TNF 9557650 499928 Furthermore , we observed that the core protein blocked the *induced* activation of [RelA/NF-kappaB] in murine BC10ME cells , thus at least partially accounting for the increased sensitivity of BC10ME cells to TNF . Positive_regulation NFKB1 TNF 9560343 500497 Dominant negative mutants of several factors that play a key role in [NF-kappaB] *induction* by [ 10 ] inhibited NF-kappaB activation by Apo3L . Positive_regulation NFKB1 TNF 9565556 500912 Interestingly , both the potent physiological inducer of NF-kappaB as well as endoplasmic reticulum overload can *induce* [NF-kappaB] via a PDTC sensitive pathway . Positive_regulation NFKB1 TNF 9570554 501585 Simultaneously applied H2O2 strongly potentiated the PDBu- or *induced* transcriptional activity of [NF-kappa B] . Positive_regulation NFKB1 TNF 9580637 504955 Because the PGHS-2 promoter has a nuclear factor-kappa B (NF-kappa B) binding motif , which is important for PGHS-2 gene transcription in some cell types , we have evaluated the effects of tyrosine kinase inhibitors and PAO on *induced* [NF-kappa B] activation . Positive_regulation NFKB1 TNF 9580637 504957 N-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) , a serine protease inhibitor , inhibited I kappa B-alpha degradation and [NF-kappa B] activation in *response* to in a dose dependent manner ( 25 , 50 , 100 microM ) . Positive_regulation NFKB1 TNF 9580637 504970 These data demonstrate that tyrosine kinase pathways are not required for *induced* [NF-kappa B] activation in MCA-101 cells and suggest that signaling via these pathways mediates TNF-alpha induced PGHS-2 mRNA accumulation via an NF-kappa B-independent mechanism . Positive_regulation NFKB1 TNF 9581775 503477 Inhibition of *induced* [NF-kappaB] activation using the antioxidant N-acetylcysteine (NAC) resulted in increased apoptosis in both U937 and U9-IIIB cells , while preactivation of NF-kappaB with the non-apoptotic inducer IL-1beta caused a relative decrease in apoptosis . Positive_regulation NFKB1 TNF 9582369 504191 Overexpression of manganese superoxide dismutase ( Mn-SOD ) in human breast cancer MCF-7 cells completely abolished mediated [NF-kappaB] *activation* , IkappaB alpha degradation , p65 nuclear translocation , and NF-kappaB dependent reporter gene expression . Positive_regulation NFKB1 TNF 9586949 504569 As the induction of various adhesion molecules by *requires* activation of the transcription factor [NF-kappaB] , the effect of curcumin on the activation of this factor in the EC was also investigated . Positive_regulation NFKB1 TNF 9588901 504693 [NF-kappaB] *activation* during IgG immune complex induced lung injury : requirements for and IL-1beta but not complement . Positive_regulation NFKB1 TNF 9593751 505810 *activated* [NF-kappaB] in Jurkat cells but not in HuT-78 cells . Positive_regulation NFKB1 TNF 9636658 513392 The role of DNA-PK , a protein kinase involved in the response to DNA damage , in the *activation* of [NF kappa B] by IR and was examined . Positive_regulation NFKB1 TNF 9636658 513409 In M059J cells , which do not express DNA-PK , IR did not activate NF kappa B , whereas *induction* of [NF kappa B] was still observed . Positive_regulation NFKB1 TNF 9636658 513419 These results indicate that DNA-PK participates in the *activation* of [NF kappa B] by IR but not by . Positive_regulation NFKB1 TNF 9642107 514181 At 150 microM LA-Plus , but not LA , inhibited *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 9647248 514968 Remarkably , TRAF2-DN overexpression , which was found to inhibit the TNF dependent recruitment of endogenous wild-type TRAF2 to the TNF-R75 signaling complex , could neither block TNF-R55- or *induced* [NF-kappaB] activation nor granulocyte/macrophage-CSF secretion . Positive_regulation NFKB1 TNF 9647248 514970 Possibly , additional factors different from TRAF2 are involved in mediated [NF-kappaB] *activation* . Positive_regulation NFKB1 TNF 9657527 516811 *activated* binding of [nuclear factor kappaB (NF-kappaB)] to its targeted DNA sequence and stimulated degradation of I-kappaBalpha , an NF-kappaB inhibitory protein . Positive_regulation NFKB1 TNF 9660769 517435 induced cell killing and *activation* of transcription factor [NF-kappaB] are uncoupled in L929 cells . Positive_regulation NFKB1 TNF 9698598 524958 Inhibition of induced [NF-kappaB] *activation* and IL-8 release in A549 cells with the proteasome inhibitor MG-132 . Positive_regulation NFKB1 TNF 9698598 524961 The working hypothesis of the studies described herein was that inhibition of proteasome mediated IkappaB degradation would inhibit induced [nuclear factor-kappaB (NF-kappaB)] *activation* , interleukin-8 (IL-8) gene transcription , and IL-8 protein release in A549 cells . Positive_regulation NFKB1 TNF 9705938 526114 TNFR-1 recruits and assembles a signaling complex containing a number of death domain ( DD ) -containing proteins , including the adaptor protein TRADD and the serine/threonine kinase RIP , which mediates *induced* [NF-kappa B] activation . Positive_regulation NFKB1 TNF 9707608 526463 The Epstein-Barr virus oncoprotein latent infection membrane protein 1 ( LMP1 ) is a constitutively aggregated that *activates* transcription factor [NF-kappaB] through two sites in its C-terminal cytoplasmic domain . Positive_regulation NFKB1 TNF 9710149 526623 We demonstrate that 0.1-0.5 microM DMDTC inhibits *induced* activation of [NF-kappaB] in primary human CD4+ T cells . Positive_regulation NFKB1 TNF 9710205 526631 High doses of NO impaired the *induced* DNA binding activity of [NF-kappaB] . Positive_regulation NFKB1 TNF 9718198 528185 These results suggest that the rapid activation of NF-kappaB by is mainly due to the nuclear translocation of NF-kappaB pre existing in cytosol , and that the subsequent increase in the expression of p50 and p65 may *result* in the persistent activation of [NF-kappaB] during TNF-alpha stimulation . Positive_regulation NFKB1 TNF 9718198 528201 These results suggest that the *activation* of [NF-kappaB] by may play an important role in the production of cytokines and cell adhesion molecules from osteoblasts , leading to the promotion of bone resorption and inflammation . Positive_regulation NFKB1 TNF 9720648 528505 Our analyses of the induction of nuclear factor-kappaB (NFkappaB) in activated memory ( CD45RO+ ) and naive ( CD45RA+ ) T cell subsets from young and elderly donors has demonstrated that , regardless of donor age , memory T cells are not significantly altered in their responsiveness to *mediated* induction of [NFkappaB] . Positive_regulation NFKB1 TNF 9727370 529921 Electrophoretic mobility shift assays ( EMSA ) showed that interleukin-1beta and *activated* [NF-kappaB] from 15 min to 48 h after stimulation . Positive_regulation NFKB1 TNF 9728048 530014 E-selectin expression in human endothelial cells by *induced* oxidant generation and [NF-kappaB] activation . Positive_regulation NFKB1 TNF 9728048 530016 Pretreatment with N-acetyl-L-cysteine (NAC) or pyrrolidine dithiocarbamate ( PDTC ) for 0.5 h inhibited *induced* generation of ROS as well as activation of [NF-kappaB] and E-selectin mRNA and the cell surface protein expression . Positive_regulation NFKB1 TNF 9728048 530027 These findings indicate that *induces* [NF-kappaB] activation and the resultant E-selectin gene expression by a pathway that involves formation of ROS and that E-selectin expression can be inhibited by the antioxidant action of NAC or PDTC . Positive_regulation NFKB1 TNF 9729336 530130 Methylprednisolone inhibition of expression and [NF-kB] *activation* after spinal cord injury in rats . Positive_regulation NFKB1 TNF 9731570 530493 Administration of uridine ( 1,000 mg/kg ) did not reduce plasma levels of and KC , [NF-kappaB] *activation* , or polymorphonuclear leukocyte sequestration , but attenuated apoptosis by 90 % to 94 % . Positive_regulation NFKB1 TNF 9733516 530712 Tumor necrosis factor alpha (TNF-alpha) binding to the potentially initiates apoptosis and *activates* the transcription factor [nuclear factor kappa B (NF-kappaB)] , which suppresses apoptosis by an unknown mechanism . Positive_regulation NFKB1 TNF 9737713 531577 Overexpression of BRE inhibited *induced* [NFkappaB] activation , indicating that the interaction of BRE protein with the cytoplasmic region of p55 TNF receptor may modulate signal transduction by TNF-alpha . Positive_regulation NFKB1 TNF 9742107 532184 Such a NIK-T559A mutant also dominantly interferes with *induction* of [NF-kappaB] . Positive_regulation NFKB1 TNF 9742107 532186 When expressed alone , this C-terminal NIK fragment functions as a potent inhibitor of mediated *induction* of [NF-kappaB] and alone is sufficient to disrupt the physical association of NIK and IKKalpha . Positive_regulation NFKB1 TNF 9743347 532403 Pretreatment of cells with IL-13 blocked induced [NF-kappa B] *activation* , nuclear translocation of p65 subunit , and degradation of I kappa B alpha . Positive_regulation NFKB1 TNF 9743347 532410 *induced* [NF-kappa B-dependent] gene transcription was also blocked by IL-13 . Positive_regulation NFKB1 TNF 9743347 532424 Thus , overall , these results demonstrate that IL-13 is a potent inhibitor of *mediated* activation of [NF-kappa B] , AP-1 , and apoptosis , which may contribute to its previously described immunosuppressive and anti-inflammatory effects . Positive_regulation NFKB1 TNF 9743348 532481 Electrophoretic mobility shift assay showed that alpha-MSH completely abolished mediated [NF-kappa B] *activation* in a dose- and time dependent manner . Positive_regulation NFKB1 TNF 9743348 532483 This correlated with suppression of [NF-kappa B-dependent] reporter gene expression *induced* by . Positive_regulation NFKB1 TNF 9743348 532485 Similarly , addition of membrane-permeable dibutyryl cAMP , like alpha-MSH , suppressed *induced* [NF-kappa B] activation . Positive_regulation NFKB1 TNF 9755059 535280 ActD did not affect *induced* hepatocyte [NF-kappaB] activation but decreased NF-kappaB dependent gene expression . Positive_regulation NFKB1 TNF 9755853 535703 [NF-kappaB] binding was rapidly *induced* by IL-1alpha or but was neither induced nor potentiated by bFGF or PDGF . Positive_regulation NFKB1 TNF 9758167 535981 The existence of a synergism between IFN-gamma and TNF-alpha in stimulating IRF-1 expression at the transcriptional level was supported by IRF-1 promoter analysis : IFN-gamma directly induced the binding of STAT-1 homodimers to the GAS element , while [NF-kappaB] binding to the kappaB sequence was *activated* by only after IFN-gamma treatment . Positive_regulation NFKB1 TNF 9759860 536552 We show that *induced* activation of [NF-kappaB] was inhibited by the well-known selective inhibitors of cytosolic phospholipase A2 (cPLA2) : the trifluoromethyl ketone analogue of arachidonic acid ( AACOCF3 ) and methyl arachidonyl fluorophosphate . Positive_regulation NFKB1 TNF 9759860 536561 The trifluoromethyl ketone analogue of eicosapentaenoic acid ( EPACOCF3 ) also suppressed induced [NF-kappaB] *activation* and inhibited in vitro cPLA2 enzyme activity with a similar potency as AACOCF3 . Positive_regulation NFKB1 TNF 9759860 536563 The arachidonyl methyl ketone analogue ( AACOCH3 ) and the eicosapentanoyl analogue ( EPACHOHCF3 ) , which both failed to inhibit cPLA2 enzyme activity in vitro , had no effect on *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 9759860 536565 *induced* [NF-kappaB] activation was also strongly reduced in cells stimulated in the presence of the secretory PLA2 ( sPLA2 ) inhibitors 12-epi-scalaradial and LY311727 . Positive_regulation NFKB1 TNF 9780008 540476 Emodin ( 3-methyl-1,6,8-trihydroxyanthraquinone ) inhibits *induced* [NF-kappaB] activation , IkappaB degradation , and expression of cell surface adhesion proteins in human vascular endothelial cells . Positive_regulation NFKB1 TNF 9792375 542535 Tat and *activated* comparable levels of [NF-kappaB] . Positive_regulation NFKB1 TNF 9792645 542604 In contrast , we find *induction* of [NF-kappaB] in murine bone marrow macrophages ( BMMs ) , is mediated , by c-Src , in a cell , and cytokine specific manner . Positive_regulation NFKB1 TNF 9794459 543057 Neutral SMase , IL-1beta , and *activated* [NF-kappaB] , as revealed by electrophoretic mobility shift assay , and its nuclear translocation , as demonstrated by immunocytochemical study . Positive_regulation NFKB1 TNF 9794905 543192 The results demonstrate that transiently *activates* [NF-kappaB] and STAT3 and increases the proliferative response of hepatocytes to HGF or TGF- by fourfold . Positive_regulation NFKB1 TNF 9811706 545797 Stable cell transfectants expressing the HCV core protein suppressed *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 9817596 546664 , which is produced by round spermatids in the testis , *increased* nuclear [NF-kappaB] binding activity when added to Sertoli cells . Positive_regulation NFKB1 TNF 9823429 549004 We found that resistance to increasing concentrations of 9NC correlated with resistance to *dependent* activation of [NF-kappa B] . Positive_regulation NFKB1 TNF 9823429 549008 Interestingly , although 9NC resistance correlated with resistance to *dependent* [NF-kappa B] activation , TNF dependent cytotoxicity in these cells was enhanced by several hundred fold despite a significant decrease in the number of TNF receptors . Positive_regulation NFKB1 TNF 9827692 550901 Although basal NF-kappaB activity decreases during myogenesis , *induced* [NF-kappaB] activity is 10 times greater in myotubes compared with myoblasts , presumably because of the stockpiling of TRAF2 protein in these cells . Positive_regulation NFKB1 TNF 9830008 551251 H2O2 and *induce* differential binding of the redox-responsive transcription factors AP-1 and [NF-kappaB] to the interleukin-8 promoter in endothelial and epithelial cells . Positive_regulation NFKB1 TNF 9830008 551272 H2O2 activated AP-1 but not NF-kappaB in A549 , whereas *activated* AP-1 as well as [NF-kappaB] . Positive_regulation NFKB1 TNF 9830008 551275 In HMEC-1 , *activated* [NF-kappaB] but not AP-1 , while H2O2 did not activate either transcription factor . Positive_regulation NFKB1 TNF 9830008 551282 *induced* [NF-kappaB] complexes containing Rel A ( p65 ) . Positive_regulation NFKB1 TNF 9862414 555904 Surprisingly , *induced* [NF-kappaB] activation was not affected by silymarin , thus demonstrating a pathway dependent inhibition by silymarin . Positive_regulation NFKB1 TNF 9872503 556904 We have demonstrated that two structurally distinct yet highly selective proteasome inhibitors ( MG341 , lactacystin ) inhibit *induced* [NFKB] activation as well as ECAM expression in human endothelial cells in vitro . Positive_regulation NFKB1 TNF 9915481 587107 EMSA showed that NF-kappaB inhibitors continuously inhibited *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 9927206 588475 However , taxol did not prevent *induced* Ikappa-Balpha phosphorylation , degradation , or [NF-kappaB] activation , indicating that TNF-alpha acts through a microtubule independent pathway . Positive_regulation NFKB1 TNF 9927690 588659 FIP-3 also was shown to bind to other cell proteins , RIP and NIK , which previously had been described as essential components of *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNF 9927690 588663 In addition , FIP-3 inhibited activation of [NF-kappaB] *induced* by , the TNFR-1 receptor , RIP , NIK , and IKKbeta , as well as basal levels of endogenous NF-kappaB in 293 cells . Positive_regulation NFKB1 TNF 9933632 589481 In neutrophils , *caused* a gliotoxin-inhibitable activation of an inducible form of [NF-kappaB] , a response that may underlie the ability of TNF-alpha to delay apoptosis at later times ( 12-24 h ) and limit its early killing effect . Positive_regulation NFKB1 TNF 9950608 589832 , IL-1beta , and TII but not IFN-gamma alone caused degradation of I kappaB , Rel A nuclear translocation , and *increased* [NF-kappaB] DNA binding activity , effects that were blocked by pretreatment with MG-132 . Positive_regulation NFKB1 TNF 9973483 596335 In the present report we demonstrate that treatment of a human T cell line ( Jurkat ) with leflunomide blocks mediated [NF-kappa B] *activation* in a dose- and time dependent manner , with maximum inhibition at 5-10 microM . Positive_regulation NFKB1 TNF 9988719 596891 Recently , we demonstrated that IFN-gamma can significantly potentiate *induced* [nuclear factor (NF)-kappaB] nuclear translocation in neuronal derived and endothelial cell lines . Positive_regulation NFKB1 TNFSF10 10521444 652803 These findings suggest that receptors *induce* apoptosis , [NF-kappaB] and JNK activation through distinct signaling pathways , and activation of NF-kappaB is not sufficient for protecting cells from TRAIL induced apoptosis . Positive_regulation NFKB1 TNFSF10 10807904 736594 Moreover , in these cell lines interleukin-6 secretion and [NF-kappaB] activation were *induced* by cross linked or non-cross linked , as well as by both receptor-specific IgGs . Positive_regulation NFKB1 TNFSF10 10807904 736598 Taken together , our data suggest that TRAIL-R1 responds to either cross linked or non-cross linked sTRAIL which signals NF-kappaB activation and apoptosis , whereas TRAIL-R2 signals [NF-kappaB] activation , apoptosis , and JNK activation only in *response* to cross linked . Positive_regulation NFKB1 TNFSF10 10823821 714857 In HeLa cells , induction of apoptosis and [nuclear factor kappaB (NF-kappaB)] activation *initiated* by or the agonistic Apo1/Fas-specific monoclonal antibody anti-APO-1 require the presence of cycloheximide ( CHX ) . Positive_regulation NFKB1 TNFSF10 10823821 714861 Inhibition of caspases prevented *induced* apoptosis , but not [NF-kappaB] activation , indicating that both pathways bifurcate upstream of the receptor-proximal caspase-8 . Positive_regulation NFKB1 TNFSF10 10958661 724872 Although it is known that ( Apo2L ) induces apoptosis and *activates* [NF-kappaB] and Jun N-terminal kinase (JNK) through receptors such as TRAIL-R1 ( DR4 ) and TRAIL-R2 ( DR5 ) , the components of its signaling cascade have not been well defined . Positive_regulation NFKB1 TNFSF10 10960439 726359 Despite the expression of TRAIL-R1 and -R2 , all 6 HCC cell lines showed resistance to TRAIL induced apoptosis with no relation to [nuclear factor kappa B (NF-kappaB)] levels *induced* by . Positive_regulation NFKB1 TNFSF10 11313369 805408 It is also known that ( TRAIL ) can *activate* [NF-kappaB] through the death receptors TRAIL-R1 and TRAIL-R2 , and decoy receptor TRAIL-R4 . Positive_regulation NFKB1 TNFSF10 11313369 805410 Furthermore , studies with NF-kappaB reporter constructs revealed that the resistance of melanoma lines to TRAIL induced apoptosis was correlated to activation of [NF-kappaB] in *response* to . Positive_regulation NFKB1 TNFSF10 11313369 805416 Therefore , these results suggest that *activation* of [NF-kappaB] by plays an important role in resistance of melanoma cells to TRAIL induced apoptosis and further suggest that inhibitors of NF-kappaB may be useful adjuncts in clinical use of TRAIL against melanoma . Positive_regulation NFKB1 TNFSF10 11461927 850948 In contrast , *induced* [NF-kappaB] activation occurred in HeLa cells only upon pretreatment with the caspase inhibitor , benzyloxycarbonyl-Val-Ala-Asp- ( OMe ) fluoromethyl ketone ( z-VAD.fmk ) , indicating that this was due to a caspase-sensitive component of TRAIL induced NF-kappaB activation . Positive_regulation NFKB1 TNFSF10 11461927 850954 We show that receptor interacting protein is recruited to the native TRAIL death inducing signaling complex (DISC) and that recruitment is enhanced in the presence of z-VAD.fmk , thus providing an explanation for the potentiation of *induced* [NF-kappaB] activation by z-VAD.fmk in TRAIL-sensitive cell lines . Positive_regulation NFKB1 TNFSF10 11464292 839434 Inhibition of protein kinase C by Gö6983 sensitized these cells to apoptotic challenges and strongly diminished *activation* of [NF-kappaB] by anti-CD95 and . Positive_regulation NFKB1 TNFSF10 11948689 930237 DeltaIkappaBalpha suppressed the transactivation of [NF-kappaB] *induced* by TNF-alpha or , as reflected by luciferase-reporter activity . Positive_regulation NFKB1 TNFSF10 12207174 983505 By blocking *induced* [NFkappaB] activation , the sensitivity of cells to undergo TRAIL induced apoptosis was significantly decreased . Positive_regulation NFKB1 TNFSF10 12218071 986415 Therefore , we investigated TRAIL sensitivity , *induced* [nuclear factor-kappaB (NF-kappaB)] activation , and expression of TRAIL in human colonic adenocarcinoma cell lines ( HT-29 , LS180 , SK-CO-1 ) . Positive_regulation NFKB1 TNFSF10 12218071 986417 Activation of NF-kappaB was variably influenced by TRAIL administration , with no consistent tendency among the cell lines , indicating that induced [NF-kappaB] *activation* might be cell-type dependent . Positive_regulation NFKB1 TNFSF10 12447876 1018202 induced [NF-kappaB] *activation* was preceded by IkappaBalpha kinase (IKK) activation and IkappaBalpha degradation and depended on TRAF2 , NF-kappaB inducing kinase (NIK) , IKK1 , and IKK2 . Positive_regulation NFKB1 TNFSF10 12513753 1027755 However , can also *trigger* transcriptional activations of the pro-oncogene of c-fos , JNK , and [NF-kappaB] by other signaling pathways downstream of FADD/caspase-8 . Positive_regulation NFKB1 TNFSF10 12517970 1039400 No additional proapoptotic effect of leucine zipper TRAIL was identified following TRAIL treatment of neutrophils in the presence of gliotoxin , an inhibitor of NF-kappaB , suggesting does not *activate* [NF-kappaB] in human neutrophils . Positive_regulation NFKB1 TNFSF10 12628743 1067156 This suggests that other factors , such as *induced* [NF-kappaB] activation or death inhibitors including c-FLIP , are involved in determining differential sensitivity to TRAIL . Positive_regulation NFKB1 TNFSF10 12642868 1069461 On the other hand , *activated* [NF-kappa B] composed of RelA-p50 heterodimer , a key transcription factor regulating cell survival , in HuH-7 and HepG2 cells . Positive_regulation NFKB1 TNFSF10 12642868 1069463 However , IFN-alpha pretreatment repressed the *mediated* activation of [NF-kappaB] and decreased its transcriptional activity in HuH-7 but not in HepG2 cells . Positive_regulation NFKB1 TNFSF10 12668516 1085983 Conversely , did not *activate* [NF-kappaB] or affect the surface expression of the inflammatory markers E-selectin , intercellular adhesion molecule-1 , and vascular cell adhesion molecule-1 . Positive_regulation NFKB1 TNFSF10 12813457 1103137 Our data describe the biological significance of *mediated* activation of [NF-kappaB] in cancer cells resistant to TRAIL mediated apoptosis : TRAIL leads to an increase in tumor cell count by a prosurvival and possibly mitogenic function . Positive_regulation NFKB1 TNFSF10 12861043 1111701 Furthermore , cFLIP over-expression activated nuclear factor (NF)-kappaB and cFLIP down-regulation attenuated [NF-kappaB] activation *induced* by TNF-alpha or . Positive_regulation NFKB1 TNFSF10 12874246 1115009 In surviving cells , *activates* [NF-kappaB] , induces expression of E-selectin , ICAM-1 , and IL-8 , and promotes adhesion of leukocytes . Positive_regulation NFKB1 TNFSF10 12885939 1116816 Moreover , [NF-kappaB] nuclear translocation *induced* by but not by TNF-alpha was abrogated by z-IETD-fmk , a caspase-8-specific inhibitor . Positive_regulation NFKB1 TNFSF10 12885939 1116821 These findings demonstrate that [NF-kappaB] is essential for monocytic maturation and is *activated* via distinct pathways , involving or not involving caspases , by the related cytokines and TNF-alpha . Positive_regulation NFKB1 TNFSF10 12960048 1143368 In addition , caspase-12 was cleaved , and phosphorylation of eukaryotic initiation factor 2alpha occurred , suggesting that an endoplasmic reticulum stress pathway was involved in addition to [NF-kappaB] induction of an extrinsic pathway , possibly *mediated* by . Positive_regulation NFKB1 TNFSF10 14739605 1181983 However , CEM cells showed a faster response to *induced* [NF-kappaB] activation than K562 cells . Positive_regulation NFKB1 TNFSF10 15252032 1289920 The late phase of the *induced* [NF-kappaB] is critically dependent on caspase 8 and can be blocked by pharmacological and genetic inhibitors of caspase 8 activation , such as benzyloxycarbonyl-VAD-fluoromethyl ketone , benzyloxycarbonyl-IETD-fluoromethyl ketone , and small interfering RNA targeting caspase 8 and FADD . Positive_regulation NFKB1 TNFSF10 15459191 1342094 Surprisingly , cFLIP ( L ) specifically blocked *induced* [NF-kappaB] activation and TRAIL dependent induction of the proinflammatory target gene interleukin-8 . Positive_regulation NFKB1 TNFSF10 15459191 1342096 Taken together , our data demonstrate that cFLIP ( L ) is not only a central antiapoptotic modulator of TRAIL mediated apoptosis but also an inhibitor of induced [NF-kappaB] *activation* and subsequent proinflammatory target gene expression . Positive_regulation NFKB1 TNFSF10 15722197 1374645 The *activation* of [NF-kappaB] and phosphatidylinositol-3 (PI3) kinase by TNF-alpha and overrides the pro-apoptotic effects of these ligands in carcinoma cells and hinders their therapeutic application . Positive_regulation NFKB1 TNFSF10 15897906 1426804 HDAC inhibitors *synergized* with by inducing DRs DR4/TRAIL-R1 and DR5/TRAIL-R2 through [NFkappaB] activation and some of the proapoptotic members of the Bcl-2 family , and engaging the mitochondrial pathway . Positive_regulation NFKB1 TNFSF10 16024612 1435237 Although alone did not *induce* [NF-kappaB] activity , TRAIL combined with z-VAD significantly increased NF-kappaB activation . Positive_regulation NFKB1 TNFSF10 16024612 1435246 These results suggest that *induces* [NF-kappaB] activation , but simultaneously abrogates NF-kappaB activation by cleaving p65 , and thereby inhibits the induction of anti-apoptotic proteins such as XIAP , which contributes to the strong apoptotic activity of TRAIL compared with other TNF family members . Positive_regulation NFKB1 TNFSF10 16024776 1435373 Overexpression of FLIP ( L ) and FLIP ( S ) inhibited Fas- as well as mediated [NF-kappaB] *activation* and apoptosis induction in IFN-gamma primed cells suggesting that both responses are coregulated at the level of the DISC . Positive_regulation NFKB1 TNFSF10 16627981 1589700 CYLD inhibits mediated [NF-kappaB] *activation* and enhances the sensitivity of HCC cells to TRAIL triggered apoptosis . Positive_regulation NFKB1 TNFSF10 16715133 1638310 We further show that whereas TMS1/ASC is not required for TNFalpha or induced *activation* of [NF-kappaB] or caspase-8 , it can promote caspase-8 activation independently of death receptor-ligand interactions . Positive_regulation NFKB1 TNFSF10 16762619 1572172 induced *activation* of [NF-kappaB] was determined by electrophoretic mobility shift assay . Positive_regulation NFKB1 TNFSF10 17050666 1636117 We studied different cell lines displaying varying responses to TRAIL and found that can *activate* [NF-kappaB] in all our cancer cell lines regardless of their TRAIL sensitivity . Positive_regulation NFKB1 TNFSF10 17613431 1768772 However , signaling also *activates* [NF-kappaB] , which induces the antiapoptotic regulators Mcl-1 and cIAP2 , thus compromising its efficacy . Positive_regulation NFKB1 TNFSF10 17613437 1768785 *induced* expression of antiapoptotic Mcl-1 and cIAP2 through activation of [NF-kappaB] . Positive_regulation NFKB1 TNFSF10 17693058 1788578 Receptor interacting protein ( RIP ) has been reported in induced *activation* of [NF-kappaB] and we show here that knockdown of RIP sensitized the resistant cells to TRAIL induced apoptosis . Positive_regulation NFKB1 TNFSF10 17706603 1789072 6-Gingerol was shown to down-regulate the expression of cIAP1 , which suppresses caspase-3/7 activity , by inhibiting *induced* [NF-kappaB] activation . Positive_regulation NFKB1 TNFSF10 17706603 1789074 These findings indicate for the first time that in gastric cancer cells , 6-gingerol enhances TRAIL induced viability reduction by inhibiting induced [NF-kappaB] *activation* while 6-shogaol alone reduces viability by damaging microtubules . Positive_regulation NFKB1 TNFSF10 17947462 1814258 Of particular interest , AS602868 strongly increased myeloma sensitivity to TRAIL in blocking *induced* [NF-kappaB] activation and in decreasing the expression of antiapoptotic proteins such as cFLIP and cIAP-1/2 . Positive_regulation NFKB1 TNFSF10 18178561 1875742 IGF1R expression *requires* [NF-kappaB] activation . Positive_regulation NFKB1 TNFSF10 18287563 1896593 also *activated* [NF-kappaB] , and inhibition of NF-kappaB sensitized cells to TRAIL induced apoptosis . Positive_regulation NFKB1 TNFSF10 18834856 1981669 In addition , *induces* the DNA binding activity of [NF-kappaB] , an important transcription factor for MMP-9 induction . Positive_regulation NFKB1 TNFSF10 18834856 1981681 The specific MEK inhibitor , U0126 , significantly blocks mediated [NF-kappaB] *activation* and subsequent MMP-9 induction . Positive_regulation NFKB1 TNFSF10 19065652 2024067 By comparison , inhibition of *stimulated* [NF-kappaB] activation by IkappaBalpha-superrepressor or the small molecule NF-kappaB inhibitor BMS-345541 significantly enhances TRAIL induced apoptosis , pointing to an antiapoptotic function of NF-kappaB in TRAIL mediated apoptosis . Positive_regulation NFKB1 TNFSF10 19372584 2058986 PRMT5 contributed to *induced* activation of inhibitor of kappaB kinase (IKK) and [nuclear factor-kappaB (NF-kappaB)] , leading to induction of several NF-kappaB target genes . Positive_regulation NFKB1 TNFSF10 19432816 2286875 Treatment of resistant cells with parthenolide , an inhibitor of inhibitor of kappaB ( I-kappaB ) , eliminated *induced* [NF-kappaB] activity but not TRAIL resistance . Positive_regulation NFKB1 TNFSF10 19895686 2165998 SH122 also suppressed *induced* [NF-kappaB] activation by preventing cytosolic IkappaB-alpha degradation and RelA nuclear translocation , as well as by suppressing NF-kappaB target gene expression . Positive_regulation NFKB1 TNFSF10 20062539 2193811 As well as causing apoptosis of certain types of tumor cells , can *activate* both [NF-kappaB] and JNK signalling pathways . Positive_regulation NFKB1 TNFSF10 20113484 2213118 The combination of GGTI-298 and TRAIL was more effective than each single agent in decreasing the levels of IkappaBalpha and p-Akt , implying that *activates* [NF-kappaB] and inhibits Akt . Positive_regulation NFKB1 TNFSF10 20150555 2227523 We conclude that TRAIL induction involves FGF-2 , Sp1-phosphorylation and [NFkappaB] and that *promotes* VSMC proliferation and neointima formation after arterial injury . Positive_regulation NFKB1 TNFSF10 20354117 2238346 In addition , ION significantly increased hepatocellular carcinoma cell sensitivity to TRAIL by abrogating *induced* [NF-kappaB] activation and decreasing the expression of antiapoptotic proteins such as XIAP and IAP-1/2 . Positive_regulation NFKB1 TNFSF10 20354842 2260905 In the present work , we analyzed cell viability , DISC formation as well as IL-8 and [NF-kappaB] activation side by side in *responses* to and agonistic antibodies against DR4 ( mapatumumab ) and against DR5 ( lexatumumab ) in pancreatic ductal adenocarcinoma cells . Positive_regulation NFKB1 TNFSF10 20451496 2275279 TRAIL treatment showed NF-kappaB translocation to the nucleus in TRAIL-resistant INS-1 cells , and *induced* [NF-kappaB] activation was preceded by IkappaBalpha degradation . Positive_regulation NFKB1 TNFSF10 20451496 2275281 A pharmacological inhibitor of NF-kappaB , Bay 11-7082 , blocked *induced* [NF-kappaB] translocation to the nucleus and IkappaBalpha degradation . Positive_regulation NFKB1 TNFSF10 20515942 2270991 Indeed , butein repressed the *mediated* activation of [NF-kappaB] and decreased its transcriptional activity . Positive_regulation NFKB1 TNFSF10 20668316 2298291 Vanillin pretreatment inhibited *induced* phosphorylation of p65 and transcriptional activity of [NF-kappaB] . Positive_regulation NFKB1 TNFSF10 20683954 2299095 Treatment with JP1584 inhibited *induced* [NF-kappaB] activation as well as TRAIL mediated up-regulation of the NF-kappaB target gene , matrix metalloproteinase 7 (MMP7) . Positive_regulation NFKB1 TNFSF10 9430228 474408 receptors 1 ( DR4 ) and 2 ( DR5 ) signal FADD dependent apoptosis and *activate* [NF-kappaB] . Positive_regulation NFKB1 TNFSF10 9616159 509569 We demonstrate here that ( TNF related apoptosis inducing ligand ) , a recently identified DIL , also *activates* [NFkappaB] in lymphoid cell lines in a kinetic similar to TNFalpha . Positive_regulation NFKB1 TNFSF10 9889416 558486 *induces* apoptosis and activation of [NFkappaB] . Positive_regulation NFKB2 IL1B 9523851 494316 IL-1alpha and markedly *increased* steady-state levels of LYT-10 ( NFkappaB2 ) transcripts and nuclear [Lyt-10] protein in both cell lines . Positive_regulation NFKBIA ANKRD1 10669735 665972 Nuclear import of [IkappaBalpha] is *mediated* by the central . Positive_regulation NFKBIA CAPN8 10521480 653028 Moreover , the muCaMLD of calpain acts as a competitive inhibitor of *dependent* [IkappaBalpha] degradation . Positive_regulation NFKBIA CAPN8 11313873 805632 Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving *mediated* degradation of [IkappaB-alpha] that can be inhibited by the tumor suppressor PTEN . Positive_regulation NFKBIA CAPN8 11313873 805672 Inhibitors of , but not the proteasome , *blocked* [IkappaB-alpha] degradation . Positive_regulation NFKBIA CAPN8 11673497 872785 Phosphorylation by the protein kinase CK2 promotes *mediated* degradation of [IkappaBalpha] . Positive_regulation NFKBIA CAPN8 11673497 872799 CK2 phosphorylation enhanced *mediated* degradation of wild-type [IkappaBalpha] , but not of mutant 3CIkappaBalpha , with S283A , T291A , and T299A mutations in phosphorylation sites within the PEST domain . Positive_regulation NFKBIA CAPN8 11673497 872813 These findings demonstrate for the first time that CK2 phosphorylation of serine/threonine residues in the PEST domain promotes *mediated* degradation of [IkappaBalpha] and thereby increases basal NF-kappaB levels in IgM ( + ) B cells . Positive_regulation NFKBIA CAPN8 14686903 1179480 However , inhibition of the glutamate activated Ca2+ dependent protease by calpeptin completely *blocked* [IkappaBalpha] degradation and reduced the nuclear translocation of p65 . Positive_regulation NFKBIA CAPN8 16271147 1484003 Constitutive degradation of [IkappaBalpha] in human T lymphocytes is *mediated* by . Positive_regulation NFKBIA CAPN8 16938483 1615397 Moreover , in these conditions , we demonstrated formation of the IkappaBalpha/calpain 3 complex and an increase in *dependent* [IkappaBalpha] cleavage products in cell nuclei . Positive_regulation NFKBIA CAPN8 18468506 1921567 To explore this potential anti-apoptotic mechanism , we inhibited calpain and proteasome activity in oridonin induced L929 cell apoptosis , and discovered that the inducible [IkappaBalpha] proteolysis was partially *blocked* by the inhibition of either or proteasome , but completely blocked by the inhibition of both . Positive_regulation NFKBIA CAPN8 18577712 1953042 The interaction of N-terminal pyrin with IkappaB-alpha induced *mediated* degradation of [IkappaB-alpha] , thus potentiating NF-kappaB activation . Positive_regulation NFKBIA CAPN8 20659425 2305136 Interestingly , the combined inhibition of and the proteasome *resulted* in an increased accumulation of both I-kappaBalpha polymers and [I-kappaBalpha] , concurrent with an inhibition of NF-kappaB activity in MDA-MB-231 cells . Positive_regulation NFKBIA CAPN8 9186501 436838 This suggests that *contributes* to silica induced [I kappa B alpha] degradation and NF-kappa B activation but not to LPS induced I kappa B alpha degradation and NF-kappa B activation . Positive_regulation NFKBIA CAPN8 9873017 583316 As additional evidence for *dependent* [IkappaBalpha] proteolysis and NF-kappaB activation , we demonstrate that this process occurs in a cell line ( ts20b ) deficient in the ubiquitin-proteasome pathway . Positive_regulation NFKBIA CTGF 16303051 1490777 *induced* [IkappaBalpha] phosphorylation and degradation as well as nuclear accumulation of NF-kappaB . Positive_regulation NFKBIA CTGF 19301259 2064253 Stimulation of JJ012 cells with also *induced* IkappaB kinase alpha/beta ( IKK alpha/beta ) phosphorylation , [IkappaBalpha] phosphorylation , p65 Ser ( 536 ) phosphorylation , and kappaB-luciferase activity . Positive_regulation NFKBIA EPHB2 15916859 1420321 Interestingly , inhibition of but not PI3K *blocked* the kainate mediated increase in [phospho-IkappaBalpha] . Positive_regulation NFKBIA EPHB2 18218857 1884139 We found that S. aureus and Pam3Cys stimulate phosphorylation of JNK , p38 MAPK , and ERK within 4 h and that blockade of JNK , but not p38 or phosphorylation , *had* an inhibitory effect on [IkBalpha] degradation and CXC chemokine production . Positive_regulation NFKBIA EPHB2 18648999 2028058 Activation of *resulted* in phosphorylation of [IkappaB-alpha] which lead to its degradation which in turn followed by nuclear translocation of NF-kappaB , which is also supported by the western blot analysis . Positive_regulation NFKBIA EPHB2 19298870 2080068 5-Hydroxyzerumbone , however , did not affect the degradation of [IkappaB-alpha] and the *activation* of p38 and in LPS treated cells . Positive_regulation NFKBIA EPHB2 9689078 522791 We have previously shown that mitogen activated protein kinase kinase 1 ( MEKK1 ) can *induce* both this site-specific phosphorylation of IkappaB alpha at Ser-32 and Ser-36 in vivo and the activity of a high molecular weight [IkappaB kinase complex] in vitro . Positive_regulation NFKBIA FAS 12055104 951691 We show that a dominant negative form of NIK ( dnNIK ) delivered by adenoviral ( Ad5dnNIK ) vector inhibits *induced* [IkappaBalpha] phosphorylation and NF-kappaB dependent gene expression in HT-29 and HeLa cells . Positive_regulation NFKBIA FAS 12934082 1132796 The total levels of p50 , p65 and IkappaBalpha remain unchanged , but the levels of phosphorylated [IkappaBalpha] and of nuclear p65 increase , in *response* to . Positive_regulation NFKBIA IL1B 10218970 608585 *caused* a rapid increase in phosphorylated [IkappaB-alpha] levels and subsequent transient decrease in IkappaB-alpha levels , an inhibitor of NF-kappaB , as revealed by Western blot analysis using specific antibodies for phosphorylated and nonphosphorylated IkappaB-alpha . Positive_regulation NFKBIA IL1B 10386984 625981 Systemic LPS , , and TNF-alpha *caused* a rapid and transient transcriptional activation of [IkappaB alpha] along the blood vessels of the entire brain ; Positive_regulation NFKBIA IL1B 10433509 634026 No induction of the endogenous inhibitors of NF-kappaB , IkappaBalpha or I-kappaBbeta , was seen at 24 h and the ability of to degrade and subsequently *induce* [IkappaBalpha] was not altered by glucocorticoids . Positive_regulation NFKBIA IL1B 10617676 657182 *caused* the translocation of p65 NF-kappaB from cytosol to the nucleus as well as the degradation of [IkappaB-alpha] in cytosol . Positive_regulation NFKBIA IL1B 10638662 660329 stimulation of cultured epithelial cells *induces* the degradation of [IkappaBalpha] and the consequent nuclear translocation of NF-lambdaB , a critical proinflammatory transcription factor in the mucosal host immune response . Positive_regulation NFKBIA IL1B 10638662 660331 Similarly , scavenging of free radicals and oxidants by pyrrolidine dithiocarbamate and dimethyl sulfoxide did not block *induced* [IkappaBalpha] degradation and NF-kappaB activation . Positive_regulation NFKBIA IL1B 11274209 819040 This regulation of NF-kappaB activation by PKCdelta was specific only for TNFalpha signaling , since lipopolysaccharide- or *induced* NF-kappaB activation and [IkappaBalpha] degradation were not inhibited by rottlerin . Positive_regulation NFKBIA IL1B 11275558 797837 Western blot analyses involving anti-IkappaB-alpha and anti-phospho IkappaB-alpha antibodies showed that *induced* transient degradation of [IkappaB-alpha] preceded by the rapid appearance of phosphorylated IkappaB-alpha , both of which were markedly blocked by N2733 . Positive_regulation NFKBIA IL1B 11428868 831565 Stimulation of hRPE with and TNF-alpha *resulted* in degradation of [IkappaB-alpha] , nuclear translocation of NF-kappaB , and prominent increases in p38 and ERK1/2 phosphorylation for as little as 3 min . Positive_regulation NFKBIA IL1B 11698503 878189 In naive cells , LPS , TNF-alpha , and *induced* [IkappaBalpha] degradation , kinase phosphorylation , and NF-kappaB DNA binding . Positive_regulation NFKBIA IL1B 11742864 887443 IkappaBbeta , but not [IkappaBalpha] degradation , *induced* by was markedly attenuated when ERK activation was inhibited and could be partially responsible for the persistent NF-kappaB activation . Positive_regulation NFKBIA IL1B 11976320 953903 In human embryonic kidney 293 cells , *induces* IkappaB kinase beta (IKKbeta) activation , [IkappaBalpha] degradation , NF-kappaB transactivation , and weak Akt activation . Positive_regulation NFKBIA IL1B 12193729 981520 In contrast , exogenously added TAT-srIkappaBalpha did not inhibit *induced* activation of extracellular signal regulated kinase , c-Jun N-terminal kinase , or p38 mitogen activated protein kinases or the phosphorylation and degradation of endogenous [IkappaBalpha] . Positive_regulation NFKBIA IL1B 12356282 993915 Treatment of cells with byakangelicol ( 50 microM ) or pyrrolidine dithiocarbamate ( PDTC ; 50 microM ) partially inhibited *induced* degradation of [IkappaB-alpha] in the cytosol , translocation of p65 NF-kappaB from the cytosol to the nucleus and the NF-kappaB-specific DNA-protein complex formation . Positive_regulation NFKBIA IL1B 12417253 1012962 Treatment of cells with sphondin ( 50 microM ) or the NF-kappaB inhibitor , PDTC ( 50 microM ) partially inhibited *induced* degradation of [IkappaB-alpha] in the cytosol and translocation of p65 NF-kappaB from the cytosol to the nucleus . Positive_regulation NFKBIA IL1B 12594282 1060899 In contrast , *induced* NF-kappa B activity and [I kappa B alpha] degradation were not affected by BMP-7 . Positive_regulation NFKBIA IL1B 14581482 1186936 Inhibition of ERK did not affect *induced* [I-kappaBalpha] phosphorylation and degradation but attenuated I-kappaBbeta degradation . Positive_regulation NFKBIA IL1B 15389584 1354333 Consistently , *stimulated* translocation of NF-kappaB into the nucleus and degradation of [IkappaB-alpha] which was blocked by helenalin , U0126 , or SP600125 . Positive_regulation NFKBIA IL1B 15450943 1300783 Epicatechin significantly reduced IL-1beta induced nitrite production , iNOS protein and mRNA expressions , and it also inhibited *induced* [IkappaBalpha] protein degradation , NF-kappaB activation , and iNOS promoter activity . Positive_regulation NFKBIA IL1B 15489374 1359437 As expected , *stimulated* translocation of NF-kappaB into the nucleus and degradation of [IkappaB-alpha] were blocked by helenalin but not by U0126 , SB-202190 , or SP-600125 . Positive_regulation NFKBIA IL1B 15550384 1360970 Iron mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha induced but not *induced* [IkappaB kinase complex/nuclear] factor-kappaB activation . Positive_regulation NFKBIA IL1B 16140882 1450816 PFE also inhibited the *induced* phosphorylation of [IkappaBalpha] and the DNA binding activity of the transcription factor NF-kappaB in OA chondrocytes . Positive_regulation NFKBIA IL1B 16249450 1471740 Expression of the NF-kappaB dependent genes [IkappaB-alpha] and monocyte chemoattractant protein (MCP)-1 was *induced* in human islets by but not by high glucose . Positive_regulation NFKBIA IL1B 16258173 1489910 Stimulation of fibroblast-like synoviocytes with *resulted* in rapid degradation of [IkappaBalpha] , an event that was preceded by IkappaBalpha phosphorylation . Positive_regulation NFKBIA IL1B 16338964 1503955 Immunoprecipitation and immunoblotting with anti-IkappaBalpha and anti-phosphotyrosine antibodies revealed that PP2 also inhibited *stimulated* tyrosine phosphorylation of [IkappaBalpha] , a requisite step in NF-kappaB activation in this signaling cascade . Positive_regulation NFKBIA IL1B 16822942 1638579 In cultured rat VSMCs , *activated* ERK and induced degradation of both [IkappaBalpha] and IkappaBbeta , which was associated with nuclear translocation of both ribosomal S6 kinase (RSK)1 and NF-kappaB p65 . Positive_regulation NFKBIA IL1B 17085450 1685067 Interestingly , AuTM does not interfere with *induced* [IkappaB alpha] degradation , in most cases a prerequisite for subsequent NFkappaB activation . Positive_regulation NFKBIA IL1B 17141217 1693755 We have further identified that interleukin-6 (IL-6) and from PMN-melanoma co-cultures synergistically *contribute* to [IkappaB-alpha] degradation and IL-8 synthesis in PMNs . Positive_regulation NFKBIA IL1B 17275031 1733245 VIP also decreased *induced* NF-kappaB DNA binding capacity and phosphorylation of [IkappaB-alpha] . Positive_regulation NFKBIA IL1B 17311279 1719301 Furthermore , *stimulated* translocation of NF-kappaB into the nucleus and degradation of [IkappaB-alpha] was blocked by helenalin . Positive_regulation NFKBIA IL1B 17335379 1707622 *increased* [phospho-IkappaBalpha] in whole cell extracts by a maximum of approximately 9.5 times ( P = 0.0001 ) , and this was inhibited significantly by NS-398 ( P < or=0.008 ) . Positive_regulation NFKBIA IL1B 17390080 1716201 Although triptolide partially suppressed *mediated* degradation of [IkappaB-alpha] and nuclear translocation of p65 NF-kappaB , triptolide potently inhibited NF-kappaB promoter-driven luciferase activity in A549 cells . Positive_regulation NFKBIA IL1B 17437195 1729077 Pretreatment with progesterone interfered with *induced* [IkappaBalpha] degradation . Positive_regulation NFKBIA IL1B 17690185 1788396 *caused* [IkappaB-alpha] phosphorylation in corneal stromal cells but not in infiltrated CD11b ( + ) cells 2 days after IL-1beta implantation . Positive_regulation NFKBIA IL1B 17693924 1882309 causes nuclear accumulation of NF-kappaB ( Rel A ) but does not *increase* nuclear [IkappaBalpha] . Positive_regulation NFKBIA IL1B 17693924 1882312 Furthermore , inhibition of exportin 1 attenuates *induced* phosphorylation of [IkappaBalpha] without affecting IkappaB kinase phosphorylation . Positive_regulation NFKBIA IL1B 17920534 1804180 *induced* phosphorylation of the mitogen activated protein ( MAP ) kinases , [IkappaBalpha] , c-Jun and Akt . Positive_regulation NFKBIA IL1B 18377686 1944118 Chrysin strongly reduced ( 2.5-fold ) *induced* [IkappaB-alpha] phosphorylation , whereas ellagic acid increased it ( 1.7-fold ) . Positive_regulation NFKBIA IL1B 18389480 1899283 Further , IL-12 , IL-23 , and IL-27 promoted basal and *induced* phosphorylation of [IkappaBalpha] . Positive_regulation NFKBIA IL1B 18515093 1939685 LCA pretreatment inhibited the *induced* [IkappaBalpha] degradation and decreased the NF-kappaB p65 phosphorylation . Positive_regulation NFKBIA IL1B 18606398 1984324 Resveratrol , like N-Ac-Leu-Leu-norleucinal (ALLN) suppressed *induced* proteasome function and the degradation of [IkappaBalpha] ( an inhibitor of NF-kappaB ) without affecting IkappaBalpha kinase activation , IkappaBalpha-phosphorylation or IkappaBalpha-ubiquitination which suppressed nuclear translocation of the p65 subunit of NF-kappaB and its phosphorylation . Positive_regulation NFKBIA IL1B 18708082 1974585 Consistently , *stimulated* both [IkappaB-alpha] degradation and NF-kappaB translocation into nucleus in these cells . Positive_regulation NFKBIA IL1B 19086277 2000197 Furthermore , LGG attenuated the IL-1beta induced transcriptional activation of the IL-8 gene and the NF-kappaB-responsive gene , and attenuated the *induced* [IkappaBalpha] degradation . Positive_regulation NFKBIA IL1B 19342688 2056879 In addition , *induced* phosphorylation of downstream effectors , IkappaB kinase alphabeta , [IkappaBalpha] , and activation of transcription factor NF-kappaB was significantly reduced in the MyD88- , IRAK1- , TRAF6- , or Ras-deficient cells . Positive_regulation NFKBIA IL1B 19357230 2081170 LXA ( 4 ) ( 10 nM ) was found to inhibit *induced* degradation of [IkappaBalpha] ( P < 0.05 ) , and the activation of an NFkappaB regulated reporter gene construct ( P < 0.05 ) . Positive_regulation NFKBIA IL1B 19369446 2081693 PD-98059 blocked *induced* phosphorylation of IKK2 , degradation of [IkappaB-alpha] , and phosphorylation and nuclear translocation of NF-kappaB subunit p65 , whereas SB-203580 had a marginal effect , implying that the effect of ERK1/2 is exerted on the canonical IKK2/IkappaB-alpha/p65 pathway of NF-kappaB activation but that the effect of p38 MAPK may not predominantly involve NF-kappaB signaling . Positive_regulation NFKBIA IL1B 19370157 2058813 This suppression of NOS2 by DCS correlates with the attenuation of the NF-kappaB signaling pathway as measured by *induced* phosphorylation of the [inhibitor of kappa B (IkappaB)-alpha] , degradation of IkappaB-alpha and IkappaB-beta , and subsequent nuclear translocation of NF-kappaB p65 . Positive_regulation NFKBIA IL1B 19669392 2186117 *increased* [IkappaB-alpha] expression ( p < 0.001 ) at 60 min and either induced iNOS ( p < 0.001 ) and IL-1beta ( p < 0.01 ) or inhibited IL-4 ( p < 0.05 ) expression at 360 min . Positive_regulation NFKBIA IL1B 19672968 2182997 *stimulated* [IkappaBalpha] degradation , NF-kappaB nuclear translocation , and transactivation in astrocytes . Positive_regulation NFKBIA IL1B 8977194 408702 We demonstrate that *induces* complete [IkappaB alpha] degradation in Caco-2 cell lines but not in HT-29 , T84 , SW-480 transformed cell lines , or native colonic epithelial cells . Positive_regulation NFKBIA IL1B 9506955 491506 However , *induced* [IkappaBalpha] degradation as well as NF-kappaB nuclear translocation and DNA binding , as determined by Western blot and electro-mobility shift assay , respectively , are not affected by these inhibitors . Positive_regulation NFKBIA IL1B 9568691 501338 TLCK and MG 132 inhibited both *induced* activation of NFkappaB and degradation of [IkappaBalpha] by islets and RINm5F cells . Positive_regulation NFKBIA IL1B 9759865 536583 However , while and TNF-alpha both induced nuclear binding of the Rel proteins p50 and p65 to an NF-kappaB consensus oligonucleotide in gel shift assays and *caused* transient degradation of inhibitor of NF-kappaB-alpha ( [IkappaB-alpha] ) in the cytoplasm of myofibroblasts , only IL-1beta upregulated PDGF-Ralpha . Positive_regulation NFKBIA IL1B 9812920 545991 Western blot analysis using anti-IkappaB-alpha and anti-phospho-IkappaB-alpha antibodies revealed that *induced* a transient degradation of [IkappaB-alpha] preceded by a rapid appearance of phosphorylated IkappaB-alpha , both of which were completely blocked by NOR3 . Positive_regulation NFKBIA IL1B 9812920 545992 A proteasome inhibitor ( MG115 ) blocked *induced* transient degradation of [IkappaB-alpha] and stabilized the appearance of phosphorylated IkappaB-alpha stimulated by IL-1beta . Positive_regulation NFKBIA IL1B 9812920 545993 NOR3 inhibited the appearance of *induced* phosphorylated [IkappaB-alpha] even in the presence of MG115 . Positive_regulation NFKBIA LBP 16123407 1449374 Combined stimulation with LPS and either sCD14 or also *induced* the phosphorylation and degradation of [IkappaB-alpha] and the translocation of NF-kappaB from the cytoplasm to the nucleus of corneal fibroblasts . Positive_regulation NFKBIA SPHK1 16038795 1437475 Suppression of activation *led* to reduction of cytokine induced [IkappaBalpha] phosphorylation and consequently diminished NFkappaB activity due to reduced nuclear translocation of RelA ( p65 ) , explaining the dependence of inflammatory mediator production on SPHK1 activation . Positive_regulation NFKBIA TLR7 17579043 1763822 Although *induced* [IkappaBalpha] degradation was not affected by FcgammaR ligation , IkappaBalpha accumulated in the nuclei of cells treated with LPS and FcgammaR ligation for 4 h , and was blocked by PI3K inhibitors . Positive_regulation NFKBIA TNF 10029619 591693 *stimulated* NF-kappaB activation and nuclear translocation and the degradation of [Ikappa-Balpha] were blocked by mesalamine . Positive_regulation NFKBIA TNF 10197731 604875 These data collectively suggest that PAO interferes with the phosphorylation and the regulated degradation of [IkappaB-alpha] , *induced* by , without affecting the chymotryptic activity of the proteasome , independent of age . Positive_regulation NFKBIA TNF 10201924 605677 In contrast , *induced* degradation of [I kappa B alpha] in the neuronal cells , suggesting that failure to induce I kappa B alpha degradation is likely due to a defect in virus mediated signaling rather than to a defect involving neuronal I kappa B alpha . Positive_regulation NFKBIA TNF 10224136 610051 All four agents caused EC apoptosis at concentrations that inhibited *induced* [IkappaBalpha] degradation . Positive_regulation NFKBIA TNF 10224136 610052 Consistent with this hypothesis , cotreatment of EC with the metalloproteinase inhibitor Tapi ( TNF-alpha proteinase inhibitor ) blocked the reduction in surface TNFR1 by apoptogenic drugs and prevented inhibition of *induced* [IkappaBalpha] degradation without blocking apoptosis . Positive_regulation NFKBIA TNF 10339475 615857 We found that overexpression of IkappaB-alpha in endothelial cells using a recombinant adenovirus prevented *induced* degradation of [IkappaB-alpha] and suppressed the upregulation of vascular cell adhesion molecule-1 ( VCAM-1 ) , intercellular adhesion molecule-1 ( ICAM-1 ) , and E-selectin mRNA and surface protein expression and the upregulation of transcripts for the chemokines monocyte chemoattractant protein 1 ( MCP-1 ) and growth related activity-alpha ( GRO-alpha ) by TNF-alpha . Positive_regulation NFKBIA TNF 10353611 617646 The association of p16INK4 with NF-kappaBp65 is considerable in HeLa- or 293 cells , if the NF-kappaB inhibitor [I kappaB alpha] is degraded in *response* to stimulation . Positive_regulation NFKBIA TNF 10386984 625980 Systemic LPS , IL-1beta , and *caused* a rapid and transient transcriptional activation of [IkappaB alpha] along the blood vessels of the entire brain ; Positive_regulation NFKBIA TNF 10428782 633245 Recently , we used the specific p38 mitogen activated protein (MAP) kinase inhibitor SB203580 to demonstrate that inhibition of *induced* [IkappaBalpha] phosphorylation requires NaSal induced p38 activation . Positive_regulation NFKBIA TNF 10428782 633248 Sorbitol , H ( 2 ) O ( 2 ) , and arsenite each blocked [IkappaBalpha] phosphorylation *induced* by , and SB203580 reversed the inhibitory effects of sorbitol and H ( 2 ) O ( 2 ) , but not arsenite . Positive_regulation NFKBIA TNF 10428782 633250 In addition , sorbitol and H ( 2 ) O ( 2 ) blocked induced but not interleukin-1 *induced* [IkappaBalpha] phosphorylation , whereas arsenite inhibited IkappaBalpha phosphorylation induced by TNF and interleukin-1 . Positive_regulation NFKBIA TNF 10490923 645821 Western blot analysis showed inhibition of *induced* [IkappaB-alpha] phosphorylation in the presence of polaprezinc . Positive_regulation NFKBIA TNF 10490994 645863 The factor did not inhibit the degradation of [I kappa B alpha] *induced* by , indicating that the target for its activity lies within an undefined part of the TNF signaling mechanism . Positive_regulation NFKBIA TNF 10581242 570229 We find can *activate* the nuclear [IkappaBalpha-NF-kappaB] complexes by the classical mechanism of proteasome mediated degradation of IkappaBalpha . Positive_regulation NFKBIA TNF 10593907 572881 Chromium did not inhibit *stimulated* [IkappaBalpha] degradation or translocation of NF-kappaB binding proteins to the nucleus . Positive_regulation NFKBIA TNF 10593965 572927 We show 5-ASA inhibits *stimulated* phosphorylation of [IkappaBalpha] in intact YAMC cells . Positive_regulation NFKBIA TNF 10619864 657395 Finally , S. typhimurium , but not , *induced* a Ca ( 2+ ) -dependent phosphorylation of [IkappaB-alpha] . Positive_regulation NFKBIA TNF 10623598 658134 TGF-beta induced matrix proteins inhibit p42/44 MAPK and JNK activation and suppress *mediated* [IkappaBalpha] degradation and NF-kappaB nuclear translocation in L929 fibroblasts . Positive_regulation NFKBIA TNF 10644755 661415 We found previously that overexpression of an F-box protein betaTrCP1 and the structurally related betaTrCP2 augments ubiquitination of phosphorylated [IkappaBalpha] ( pIkappaBalpha ) *induced* by , but the relationship of the two homologous betaTrCP proteins remains unknown . Positive_regulation NFKBIA TNF 10671572 667271 *induced* normal phosphorylation of [IkappaBalpha] but failed to induce degradation of phosphorylated IkappaBalpha . Positive_regulation NFKBIA TNF 10734145 678904 We also found that the carboxyl-terminal half of FIP3 blocked *induced* [IkappaB-alpha] phosphorylation and subsequent degradation , which suggests that the stabilization of the cytoplasmic inhibitor of NF-kappaB underlies the FIP3 inhibition of NF-kappaB activity . Positive_regulation NFKBIA TNF 10753891 682360 We previously demonstrated that salicylate inhibits IkappaBalpha degradation induced by tumor necrosis factor (TNF) but not by interleukin-1 (IL-1) and implicated p38 mitogen activated protein kinase activation by salicylate in the inhibition of *induced* [IkappaBalpha] phosphorylation . Positive_regulation NFKBIA TNF 10788437 688679 Treatment of the CaCOV3 human ovarian cell line with hCG blocked *induced* activation of NF-kappaB , [IkappaBalpha] degradation , and NF-kappaB dependent reporter gene transcription . Positive_regulation NFKBIA TNF 10869349 730114 and interleukin-1 *induce* [I kappa B-alpha] phosphorylation , leading to I kappa B-alpha degradation and translocation of NF-kappa B to the nucleus where it activates genes important in inflammatory and immune responses . Positive_regulation NFKBIA TNF 10976991 729656 Northern blot analysis revealed that Dex *increased* [IkappaB-alpha] mRNA level synergistically with , whereas it decreased p65 mRNA level . Positive_regulation NFKBIA TNF 10982546 732001 Adiponectin suppressed *induced* [IkappaB-alpha] phosphorylation and subsequent NF-kappaB activation without affecting other TNF-alpha mediated phosphorylation signals , including Jun N-terminal kinase , p38 kinase , and Akt kinase . Positive_regulation NFKBIA TNF 10984605 732248 *stimulated* serine phosphorylation and degradation of the inhibitory protein [I kappa B alpha] and strongly induced nuclear NF-kappa B translocation and binding activity . Positive_regulation NFKBIA TNF 11049108 743167 In murine fibroblasts having genetic ablation of the heat shock factor-1 gene , heat shock inhibited *mediated* degradation of [I-kappaBalpha] . Positive_regulation NFKBIA TNF 11067959 747613 Leflunomide suppressed *induced* phosphorylation of [I-kappaBalpha] , as well as activation of I-kappaBalpha kinase-beta located downstream to NIK . Positive_regulation NFKBIA TNF 11068016 747626 *induced* a rapid phosphorylation and degradation of [IkappaB-alpha] in neutrophils . Positive_regulation NFKBIA TNF 11096064 802168 OFF also inhibited *induced* [IkappaBalpha] degradation and TNF-alpha induced IkappaB kinase (IKK) activity in a shear stress dependent manner . Positive_regulation NFKBIA TNF 11238593 790756 stimulation *induced* similar levels of phosphorylation and degradation of [IkappaBalpha] in embryonic fibroblasts from either wild-type or NIK-mutant mice . Positive_regulation NFKBIA TNF 11262181 796269 Inhibition of isoprenylation of Rho proteins by use of the HMG-CoA reductase inhibitor lovastatin attenuated UV- , doxorubicin- , and *induced* degradation of [IkappaBalpha] as well as drug stimulated DNA binding activity of NF-kappaB . Positive_regulation NFKBIA TNF 11278695 811128 As a consequence , expression of Vpu in HIV infected T cells or in HeLa cells inhibited *induced* degradation of [IkappaB-alpha] . Positive_regulation NFKBIA TNF 11289659 800580 GSNO inhibits NFkappaB activity in association with inhibiting *induced* degradation of [IkappaB alpha] . Positive_regulation NFKBIA TNF 11327828 807822 This inhibition was reversed by addition of the denitrosylating agent dithiothreitol to cellular extracts , whereas NO bioactivity did not affect the *induced* degradation of [IkappaBalpha] or the nuclear translocation of p65 . Positive_regulation NFKBIA TNF 11350057 814603 Expression of I(kappa)B-alpha from the constitutive , non-NF-kappaB regulated cytomegalovirus promoter in HT-29 cells showed that or IL-1beta treatment *increased* [I(kappa)B-alpha] levels in the absence of transcriptional activation . Positive_regulation NFKBIA TNF 11350057 814604 The *induced* increase in transgenic [I(kappa)B-alpha] appeared to result from the stabilization of newly synthesized I(kappa)B-alpha , since this increase was effectively preempted by a proteasome inhibitor ( MG132 ) or by I(kappa)B-alpha stabilization through the deletion C-terminal destabilizing elements ( without additive or synergistic effects ) . Positive_regulation NFKBIA TNF 11415944 829175 Treatment with H2O2 also inhibited tumor necrosis factor (TNF)-alpha induced IkappaBalpha breakdown , NF-kappaB DNA binding activity , and NF-kappaB dependent transcription but had no effect on *induced* [IkappaBalpha] phosphorylation or ubiquitination . Positive_regulation NFKBIA TNF 11428868 831564 Stimulation of hRPE with IL-1beta and *resulted* in degradation of [IkappaB-alpha] , nuclear translocation of NF-kappaB , and prominent increases in p38 and ERK1/2 phosphorylation for as little as 3 min . Positive_regulation NFKBIA TNF 11472980 841554 In contrast , geldanamycin did not affect *mediated* degradation of the NF-kappaB inhibitory protein [IkappaBalpha] and did not block nuclear translocation of the NF-kappaB p65 subunit as measured by Western blot analyses . Positive_regulation NFKBIA TNF 11513977 849284 *induced* phosphorylation and degradation of [I kappa B-alpha] , however , were not affected . Positive_regulation NFKBIA TNF 11515677 851105 Stimulation with *resulted* in rapid phosphorylation and degradation of [IkappaBalpha] followed by NF-kappaB nuclear translocation . Positive_regulation NFKBIA TNF 11519479 851885 In contrast to glial cells , [IkappaBalpha-WT] was degraded in neuronal cells in *response* to but not MV . Positive_regulation NFKBIA TNF 11543670 855219 Although either okadaic acid or treatment of infected cells can *induce* [IkappaBalpha] phosphorylation , further processing of IkappaBalpha is inhibited . Positive_regulation NFKBIA TNF 11572859 882356 Butyrate also reduced the extent of *induced* [IkappaB-alpha] degradation and enhanced the presence of ubiquitin conjugated IkappaB-alpha . Positive_regulation NFKBIA TNF 11698503 878188 In naive cells , LPS , , and IL-1beta *induced* [IkappaBalpha] degradation , kinase phosphorylation , and NF-kappaB DNA binding . Positive_regulation NFKBIA TNF 11715495 581293 To investigate whether could *activate* the signaling pathway-NF-kappa [B/I-kappa B alpha] required for the expression of inducible nitric oxide synthase (iNOS) to induce endothelial cell apoptosis by nitric oxide ( NO ) . Positive_regulation NFKBIA TNF 11781145 900168 DEX , but not IL-4 , could strongly augment the *induced* expression of [IkappaBalpha] in SCC cells . Positive_regulation NFKBIA TNF 11799112 922275 PTEN failed to block *induced* IKK activation , [IkappaBalpha] degradation , p105 processing , p65 ( RelA ) nuclear translocation , and DNA binding of NF-kappaB . Positive_regulation NFKBIA TNF 11815432 907649 MG132 dose-dependently inhibited vascular smooth muscle cell proliferation with 50 % inhibition at 10 micromol/L. *induced* degradation of [IkappaBalpha] and beta was blocked , and activation of nuclear factor kappa B was suppressed in a concentration dependent manner in bandshift assays . Positive_regulation NFKBIA TNF 11864973 936917 In contrast , proteasome inhibitor MG-132 and lactacystin blocked both *induced* degradation of [IkappaBalpha] and down-regulation of D-type cyclins . Positive_regulation NFKBIA TNF 11950839 953618 A small molecule inhibitor of NF-kappaB dependent cytokine expression was discovered that blocked *induced* [IkappaB(alpha)] degradation in MM6 cells but not the degradation of beta-catenin in Jurkat cells . Positive_regulation NFKBIA TNF 11950839 953623 We propose that Ro106-9920 selectively inhibits an uncharacterized but essential ubiquitination activity associated with LPS- and *induced* [IkappaB(alpha)] degradation and NF-kappaB activation . Positive_regulation NFKBIA TNF 11954826 930698 Stimulation with alone *increased* NF-kappaB activation within 1 h and induced [IkappaB alpha] degradation within 0.5 h . Positive_regulation NFKBIA TNF 11971029 933554 DMF does not inhibit *induced* [I kappa B alpha] phosphorylation and I kappa B degradation ; Positive_regulation NFKBIA TNF 11994483 939070 LXA ( 4 ) analog did not affect earlier stimulus induced signaling events that lead to IkappaBalpha degradation , such as S. typhimurium induced epithelial Ca ( 2+ ) mobilization or *induced* phosphorylation of [IkappaBalpha] . Positive_regulation NFKBIA TNF 12021482 943213 Western blot analysis revealed that *caused* degradation of [I kappa B alpha] within 10 min. EMSA demonstrated that TNF-alpha led to increased DNA binding activity of NF kappa B and that proteasome inhibitors counteracted NF kappa B activation . Positive_regulation NFKBIA TNF 12060665 975674 Ectopic expression of protein-tyrosine kinase Bcr-Abl suppresses *induced* NF-kappa B activation and [IkappaBalpha] phosphorylation . Positive_regulation NFKBIA TNF 12060665 975684 *induced* [IkappaBalpha] phosphorylation and degradation in MO7E cells but not in MBA cells . Positive_regulation NFKBIA TNF 12121873 965124 mediated IKK activation *leads* to [IkappaBalpha] and IkappaBbeta degradation . Positive_regulation NFKBIA TNF 12135603 967390 ANP did not alter *induced* phosphorylation and degradation of [IkappaB-alpha] , but attenuated degradation of IkappaB-epsilon . Positive_regulation NFKBIA TNF 12153521 971461 We found that *causes* rapid degradation of [IkappaBalpha] and IkappaBbeta . Positive_regulation NFKBIA TNF 12244195 990598 Prolonged ( 2-h ) stimulation with and LPS *induces* resynthesis of [IkappaBalpha] that is again translocated to the nucleus in human neutrophils , but not in monocytic cells . Positive_regulation NFKBIA TNF 12356823 994050 Exposure to NaOCl ( 0.75 mM ) for 10 minutes caused suppression of *induced* increases in IL-1alpha mRNA and protein , declines in NFkappaB nuclear transfer , and a modification of [IkappaBalpha] , based on a bandshift detected by Western blot analysis . Positive_regulation NFKBIA TNF 12399621 1009123 SIN-1 dose dependently inhibited the TNF-alpha- or IL-1beta induced NF-kappaB binding activity and suppressed the *induced* degradation of [IkappaB-alpha] . Positive_regulation NFKBIA TNF 12402173 1009435 In addition , , but not interleukin-1 (IL-1) or lipopolysaccharide (LPS) , stimulation *resulted* in [IkappaBalpha] phosphorylation and degradation in two neuronal cell lines . Positive_regulation NFKBIA TNF 12444159 1017404 When examined for the mechanism , we found that piceatannol inhibited *induced* IkappaBalpha phosphorylation , p65 phosphorylation , p65 nuclear translocation , and [IkappaBalpha] kinase activation , but had no significant effect on IkappaBalpha degradation . Positive_regulation NFKBIA TNF 12606947 1062998 The suppression of TNF induced NF-kappaB activation by adenosine was found not to be because of inhibition of *induced* IkappaBalpha phosphorylation and degradation or [IkappaBalpha] kinase activation . Positive_regulation NFKBIA TNF 12682486 1077809 Gabexate mesilate inhibited the *induced* degradation of [IkappaBalpha] , an inhibitor of nuclear factor-kappaB , by inhibiting phosphorylation of IkappaBalpha in HUVECs . Positive_regulation NFKBIA TNF 12692090 1093275 Only at high concentrations , cPG enhanced TNF-alpha induced cell death and inhibited *induced* IkappaB-alpha kinase (IKK) activation , [IkappaB-alpha] degradation , and NF-kappaB/p65 translocation , while promoting AP-1/c-jun phosphorylation . Positive_regulation NFKBIA TNF 12704657 1082383 The *induced* stabilization of newly synthesized [IkappaBalpha] involves the C-terminal PEST region of the protein : N-terminal deletion mutants ( lacking the IkappaB kinase phosphorylation sites ) were readily stabilized by TNF-alpha , whereas deletion of the C-terminus resulted in a constitutively stable protein . Positive_regulation NFKBIA TNF 12767906 1094468 Indeed , TNF alpha induced NF-kappa B translocation was not sufficient to support enhancement of the transcription and des-IGF-1 did not promote but partly inhibited both the *induced* NF-kappa B activation and [I kappa B alpha] degradation through a PI-3K dependent pathway . Positive_regulation NFKBIA TNF 12867425 1141848 A role for NF-kappaB essential modifier/IkappaB kinase-gamma ( NEMO/IKKgamma ) ubiquitination in the *activation* of the [IkappaB kinase complex] by . Positive_regulation NFKBIA TNF 14607843 1200401 Depletion of TRP14 augmented the *induced* phosphorylation and degradation of [I kappa B alpha] as well as the consequent activation of NF-kappa B to a greater extent than did Trx1 depletion . Positive_regulation NFKBIA TNF 14612948 1163449 N-acetyl-L-cysteine did not influence the effect of EPA on *stimulated* [IkappaBalpha] degradation . Positive_regulation NFKBIA TNF 14764716 1207365 We found that overexpression of IKKgammaC417R severely impaired LPS- and *induced* [I-kappaBalpha] phosphorylation and degradation in a dominant negative fashion . Positive_regulation NFKBIA TNF 15068390 1184289 Removal of after stimulation *resulted* in a faster decrease in both NF-kappa B DNA binding activity and [I kappa B-alpha] mRNA levels . Positive_regulation NFKBIA TNF 15167972 1253505 Moreover , the inhibitory effects of IVIG on [IkappaBalpha] degradation , interleukin-6 (IL-6) production , and E-selectin expression *induced* by were evaluated by Western blot analysis , ELISA , and flow cytometry , respectively . Positive_regulation NFKBIA TNF 15167972 1253510 Moreover , IVIG inhibited [IkappaBalpha] degradation , IL-6 production , and E-selectin expression *induced* by in CAEC . Positive_regulation NFKBIA TNF 15209353 1261758 Here , we demonstrate that dehydrocostus lactone ( DL ) , the major sesquiterpene lactone isolated from the roots of Saussurea lappa , inhibits NF-kappaB activation by preventing *induced* degradation and phosphorylation of its inhibitory protein [I-kappaB alpha] in human leukemia HL-60 cells and that DL renders HL-60 cells susceptible to TNF-alpha induced apoptosis by enhancing caspase-8 and caspase-3 activities . Positive_regulation NFKBIA TNF 15240695 1270327 Jurkat cells that did not express Syk ( JCaM1 , JCaM1/lck ) showed lack of TNF induced Syk , JNK , p38 MAPK , and p44/p42 MAPK activation , as well as *induced* [IkappaBalpha] phosphorylation , IkappaBalpha degradation , and NF-kappaB activation . Positive_regulation NFKBIA TNF 15265936 1275715 Celecoxib inhibited *induced* [I kappa B alpha] kinase activation , leading to suppression of I kappa B alpha phosphorylation and degradation . Positive_regulation NFKBIA TNF 15390118 1304806 *induced* a time dependent degradation of [IkappaB-alpha] in microglial cells that was reverted by two inhibitors of nuclear factor kappaB activation , N-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) and N-CBZ-Leu-Leu-Leu-al ( MG132 ) . Positive_regulation NFKBIA TNF 15536134 1336413 Moreover , *dependent* histone H3 acetylation , release of [IkappaBalpha] from the hes1 promoter , and hes1 mRNA synthesis are affected in IKK-alpha ( -/- ) mouse embryonic fibroblasts . Positive_regulation NFKBIA TNF 15550448 1367863 In contrast , *resulted* in higher [IkappaB-alpha] kinase activity at 20 min than at 10 min , and similar low IkappaB-alpha at 10 and 20 min . Positive_regulation NFKBIA TNF 15554267 1338747 Moreover , a gel shift analysis indicated that vitamin C dose-dependently inhibited the NF-kappaB activation and [IkappaBalpha] degradation *induced* by . Positive_regulation NFKBIA TNF 15637292 1381112 Western blot analysis revealed that , in both the presence and absence of TSH , degradation of a cytosolic kappaB inhibitor ( [IkappaBalpha] ) occurred in *response* to , resulting in nuclear translocation of p65 in both conditions . Positive_regulation NFKBIA TNF 15647756 1363642 In this study , we have compared *induced* activation of NF-kappaB , phosphorylation of [IkappaBalpha] , and the expression of IKKbeta between lymphocytes from young and aged humans . Positive_regulation NFKBIA TNF 15687330 1402545 2 ) Thal significantly inhibits the *induced* expression of phosphorylated [IkappaBalpha] and degradation of IkappaBalpha ; Positive_regulation NFKBIA TNF 15870903 1405570 In addition , GA inhibited *induced* phosphorylation of p38 MAPK and extracellular regulated kinases (ERK) , [I kappa B alpha] degradation , and NF-kappa B activation . Positive_regulation NFKBIA TNF 15922746 1413845 Moreover , blocking HSP70 induction delayed *induced* [IkappaBalpha] degradation and the resolubilization of IKK . Positive_regulation NFKBIA TNF 15934029 1414648 Moreover , the extract prevented *induced* [IkappaBalpha] degradation and the binding of NF-kappaB to the DNA . Positive_regulation NFKBIA TNF 15980038 1465265 Gene transfer of FADD inhibited *induced* [IkappaB-alpha] phosphorylation , decreased p65 nuclear translocation and NF-kappaB DNA binding activity , and reduced VCAM-1 transcript levels by 53-65 % . Positive_regulation NFKBIA TNF 16117790 1449211 Degradation of inhibitor of nuclear factor kappa B ( [IkappaB) alpha] upon *stimulation* with IFNgamma and was not affected by the addition of RXM . Positive_regulation NFKBIA TNF 16129813 1450024 TDZD-8 completely prevented the *induced* [inhibitor of NF-kappaB (IkappaB)-alpha] degradation but had no effect on IkappaB-kinase-beta phosphorylation . Positive_regulation NFKBIA TNF 16129813 1450030 GSK-3 regulates *induced* [IkappaB-alpha] degradation and NF-kappaB activation independent of IkappaB-kinase-beta and subsequent induction of TF and VCAM-1 expression in human endothelial cells . Positive_regulation NFKBIA TNF 16133867 1450240 Moreover , polyamine depletion of DN-Akt cells prevented basal and *induced* [IkappaBalpha] phosphorylation . Positive_regulation NFKBIA TNF 16181613 1468117 Immunoblot experiments demonstrated that honokiol inhibited the *stimulated* phosphorylation and degradation of the cytosolic NF-kappaB inhibitor [IkappaBalpha] . Positive_regulation NFKBIA TNF 16288471 1509673 *stimulated* translocation of NF-kappaB into the nucleus and degradation of [IkappaB-alpha] was blocked by helenalin , but not by U0126 , SB202190 , or SP600125 . Positive_regulation NFKBIA TNF 16303143 1546890 Further , stimulation *induced* the degradation of [IkappaB-alpha] and resulted in the transcriptional activation of NF-kappaB . Positive_regulation NFKBIA TNF 16360644 1512314 EqM inhibits *induced* [IkappaBalpha] phosphorylation and degradation by targeting IKKbeta , and an alanine substitution for Cys179 in the activation loop of IKKbeta makes it resistant to EqM mediated inhibition . Positive_regulation NFKBIA TNF 16371367 1519659 After [IkappaBalpha] degradation in *response* to , HDAC3 is subject to nuclear translocation , leading to an increase in HDAC3 activity in the nucleus . Positive_regulation NFKBIA TNF 16377638 1526971 We also found that SAHA had no effect on direct binding of NF-kappaB to the DNA but inhibited sequentially the induced *activation* of IkappaBalpha kinase , [IkappaBalpha] phosphorylation , IkappaBalpha ubiquitination , IkappaBalpha degradation , p65 phosphorylation , and p65 nuclear translocation . Positive_regulation NFKBIA TNF 16490171 1528587 NAC inhibited the phosphorylation of IKKbeta , IKK alpha , and [IkappaB alpha] *induced* by , but had no effect on the phosphorylation of IKKbeta , IKK alpha and IkappaB alpha induced by IL-1 . Positive_regulation NFKBIA TNF 16490171 1528589 PDTC did not inhibit the phosphorylation of [IkappaB alpha] *induced* by or IL-1 . Positive_regulation NFKBIA TNF 16507601 1581854 This is supported by the observation that [IkappaBalpha] degradation *induced* by was inhibited by 1,25 ( OH ) 2D3 in VDR+/- cells , but not in VDR-/- cells . Positive_regulation NFKBIA TNF 16540674 1537106 In further studies , capsaicin inhibited *stimulated* degradation of [IkappaBalpha] in PC-3 cells , which was associated with the inhibition of proteasome activity . Positive_regulation NFKBIA TNF 16571778 1555994 *increased* the expression of [IkappaBalpha] , and dexamethasone increased it further . Positive_regulation NFKBIA TNF 16584809 1562503 *activates* the degradation of [IkappaB-alpha] and the nuclear import of cytoplasmic NF-kappaB . Positive_regulation NFKBIA TNF 16604092 1562649 In accordance with this result , rosmarinic acid also inhibited *induced* phosphorylation and degradation of [IkappaB-alpha] , as well as nuclear translocation of NF-kappaB heterodimer induced by TNF-alpha . Positive_regulation NFKBIA TNF 16606632 1611835 We further propose a potential mechanism for this observation by demonstrating that zinc supplementation induces phosphorylation of the members of three major MAPK subfamilies regulating AP-1 and NF-kappaB activation ( ERK 1/2 , JNK and p38 ) while blocking *mediated* degradation of the inhibitory subunit [I kappa B alpha] and nuclear translocation of RelA in prostate cancer cells . Positive_regulation NFKBIA TNF 16624823 1569385 The suppression of NF-kappaB activation correlated with sequential inhibition of the induced *activation* of IkappaBalpha kinase , [IkappaBalpha] phosphorylation , IkappaBalpha degradation , p65 phosphorylation , p65 nuclear translocation , and the NF-kappaB dependent reporter gene expression activated by TNF , TNFR1 , TRAF2 , NIK , IKK-beta , and the p65 subunit of NF-kappaB . Positive_regulation NFKBIA TNF 16644735 1583266 Mechanistically , our data indicated that , in *response* to , NFkappaB/p65 phosphorylation and translocation as well as [IkappaBalpha] phosphorylation and degradation were unchanged , suggesting that Lnk does not modulate NFkappaB activity . Positive_regulation NFKBIA TNF 16684960 1598539 CK2 inhibition also resulted in impaired IL-6 dependent STAT3 activation and in decreased basal and *dependent* [I kappaB alpha] degradation and NF-kappaB-driven transcription . Positive_regulation NFKBIA TNF 16863996 1592489 These redox alterations were found to inhibit *induced* [IkappaB-alpha] phosphorylation and NF-kappaB translocation to the nucleus , thus presumably inhibiting expression of genes necessary to inhibit the cytotoxic effects of TNF . Positive_regulation NFKBIA TNF 16872805 1672445 Ad.IKKbeta+/- treatment completely inhibited *stimulated* IKK kinase activity , [IkappaB alpha] degradation and NFkappaB DNA binding in addition to completely blocking TNFalpha stimulated ICAM-1 and VCAM-1 expression . Positive_regulation NFKBIA TNF 16904979 1601513 Therefore , we investigated the role of clathrin heavy chain (CHC) in *induced* [IKB alpha] phosphorylation and NFKB activation . Positive_regulation NFKBIA TNF 16920299 1666191 Furthermore , CML-1 inhibited *induced* IkB kinase activation , subsequent degradation of [IkBalpha] , and nuclear translocation of NK-kB . Positive_regulation NFKBIA TNF 16936134 1608933 The extent of inhibition of endothelial cell sprouting in 3D matrix , the blockade of *induced* [IkappaB-alpha] degradation , levels of global polyubiquitinated proteins , and induced production of HO-1 in response to treatment by the withanolides in cultured endothelial cells was similarly regulated between HCECs and HUVECs . Positive_regulation NFKBIA TNF 16966432 1616116 Further studies showed that honokiol blocked *induced* phosphorylation , ubiquitination , and degradation of [IkappaBalpha] through the inhibition of activation of IkappaBalpha kinase and of Akt . Positive_regulation NFKBIA TNF 16998237 1647263 CDDO-Me also blocked alpha *induced* phosphorylation of [IkappaBalpha] . Positive_regulation NFKBIA TNF 17095620 1693152 SDX-308 effectively suppressed *induced* IKK-gamma and [IkappaB-alpha] phosphorylation and degradation and subsequent NF-kappaB activation in human multiple myeloma cells . Positive_regulation NFKBIA TNF 17110449 1732113 Celastrol was found to inhibit the induced *activation* of IkappaBalpha kinase , [IkappaBalpha] phosphorylation , IkappaBalpha degradation , p65 nuclear translocation and phosphorylation , and NF-kappaB mediated reporter gene expression . Positive_regulation NFKBIA TNF 17114179 1677153 Gamma-tocotrienol blocked *induced* phosphorylation and degradation of [IkappaBalpha] through the inhibition of IkappaBalpha kinase activation , thus leading to the suppression of the phosphorylation and nuclear translocation of p65 . Positive_regulation NFKBIA TNF 17161959 1694546 Upon examination of the signaling components , we found that was a potent *activator* of p38 , p44/42 , p54/46 MAPK , and [IkappaBalpha] ( IkappaBalpha ) . Positive_regulation NFKBIA TNF 17202332 1680898 Moreover , guanosine abrogated IFN-gamma induced phosphorylation on Ser ( 727 ) and translocation of STAT-1alpha to the nucleus as well as *induced* [IkappaBalpha] and NF-kappaB p65/RelA subunit phosphorylation , thus inhibiting NF-kappaB induced nuclear translocation . Positive_regulation NFKBIA TNF 17244613 1710232 This confirmed that *induced* [IkappaBalpha] degradation absolutely requires NEMO and IKKbeta . Positive_regulation NFKBIA TNF 17277159 1697888 Simvastatin inhibited *induced* [IkappaBalpha] kinase activation , which led to inhibition of IkappaBalpha phosphorylation and degradation , suppression of p65 phosphorylation , and translocation to the nucleus . Positive_regulation NFKBIA TNF 17314215 1740837 Artesunate also prevented *induced* nuclear NF-kappaB translocation , DNA binding activity and gene transcriptional activity , as well as phosphorylation and degradation of [IkappaBalpha] , but phosphorylation of p38 mitogen activated protein kinase , extracellular signal regulated kinase and c-Jun N-terminal kinase were unaffected . Positive_regulation NFKBIA TNF 17327432 1706610 These inhibitory effects may be exerted via inhibition of nuclear factor-kappaB (NF-kappaB) activation , as LR-90 suppressed both S100b-and *induced* [IkappaB-alpha] degradation as well as NF-kappaB promoter transcriptional activity . Positive_regulation NFKBIA TNF 17548155 1762593 Pretreatment with C-K or Rh ( 2 ) suppressed *induced* phosphorylation of IkappaBalpha kinase and the subsequent phosphorylation and degradation of [IkappaBalpha] . Positive_regulation NFKBIA TNF 17617381 1769546 Methylglyoxal slightly delayed , but did not inhibit , *induced* degradation of [IkappaBalpha] and strongly inhibited TNF induced NF-kappaB dependent re-synthesis of IkappaBalpha . Positive_regulation NFKBIA TNF 17636246 1793105 Interestingly , we also showed that DNCB inhibited the degradation of [IkappaB-alpha] *induced* by leading to alteration of CD40 , HLA-DR , and CD83 expression but not of CD86 and CCR7 . Positive_regulation NFKBIA TNF 17641059 1771329 Further investigation revealed that induced [I kappaB alpha] kinase *activation* , I kappaB alpha phosphorylation , I kappaB alpha degradation , and p65 nuclear translocation were all suppressed in MKK4-KO cells . Positive_regulation NFKBIA TNF 17667842 1805300 stimulation also *increased* the degradation of [IkappaB-alpha] , which was restored with the addition of AZM . Positive_regulation NFKBIA TNF 17872494 1848937 Pretreatment with 100 nM 14,15-EET prevented *induced* [IkappaBalpha] degradation , as demonstrated by an increase in IkappaBalpha protein levels on Western blot analysis . Positive_regulation NFKBIA TNF 17947492 1814265 Low nanomolar concentrations of 4204 blocked the ability of lipopolysaccharide and to *induce* the release of nitric oxide and interleukin 6 and the degradation of [IKBalpha] in RAW264.7 macrophage-like cells . Positive_regulation NFKBIA TNF 17961489 1844747 In this pathway , *induces* the phosphorylation , ubiquitination , and proteasomal degradation of [IkappaBalpha] , which leads to the release and translocation of the NFkappaB transcriptional complex into the nucleus . Positive_regulation NFKBIA TNF 17994120 1860081 This study found that fludarabine inhibited *stimulated* degradation of [IkappaBalpha] , resulting in blockade of nuclear translocation of nuclear factor kappaB (NF-kappaB) in Jurkat T cells , as measured by western blot analysis and immunocytochemistry . Positive_regulation NFKBIA TNF 18029910 1827996 Similar to the MAP kinases , ouabain did not affect *induced* degradation of [IkappaB-alpha] . Positive_regulation NFKBIA TNF 18336852 1912250 Furthermore , the involvement of NF-kappaB in TNF-alpha induced MMP-9 production was consistent with that *stimulated* degradation of [IkappaB-alpha] and translocation of NF-kappaB into the nucleus which were blocked by helenalin , but not by U0126 and SP600125 , revealed by immunofluorescence staining . Positive_regulation NFKBIA TNF 18346759 1892212 We demonstrated that TNFalpha stimulates IkappaB-alpha phosphorylation through induction of IKK activity , and that fenofibrate inhibits IKK activity and *induced* [IkappaB-alpha] phosphorylation . Positive_regulation NFKBIA TNF 18410682 1925991 Furthermore , HSP70 also significantly inhibited nuclear translocation of nuclear factor-kappaB and degradation of [IkappaBalpha] *induced* by . Positive_regulation NFKBIA TNF 18442799 1900636 Treatment with the MEK inhibitor U0126 and the p38 MAP kinase inhibitor SB203580 , but not the JNK inhibitor SP600125 , reversed the diminished expression of cell surface TNF-R1 as well as the blockade of *induced* [IkappaBalpha] degradation in Ac-CHX treated cells . Positive_regulation NFKBIA TNF 18515093 1939687 LCA pretreatment was not able to prevent *induced* [IkappaBalpha] degradation in MEF VDR ( -/- ) , whereas LCA stabilized IkappaBalpha in MEF VDR ( +/- ) cells . Positive_regulation NFKBIA TNF 18582564 1946706 Insulin markedly increased induced NF-kappaB activation and *induced* phosphorylated [IkappaB-alpha] accumulation . Positive_regulation NFKBIA TNF 18597869 2059260 Metformin inhibits *induced* IkappaB kinase phosphorylation , [IkappaB-alpha] degradation and IL-6 production in endothelial cells through PI3K dependent AMPK phosphorylation . Positive_regulation NFKBIA TNF 18597869 2059276 Pre-treatment with metformin ( 100-1000 micromol/L ) also inhibited *induced* IL-6 production , phosphorylation of IkappaB kinase (IKK) alpha/beta and [IkappaB-alpha] degradation . Positive_regulation NFKBIA TNF 18597869 2059277 Metformin increased phosphorylation of AMP activated kinase (AMPK) but wortmannin , a PI3K inhibitor , negated its effects on AMPK phosphorylation and *induced* [IkappaB-alpha] degradation . Positive_regulation NFKBIA TNF 18597869 2059282 Metformin had anti-inflammatory effects on endothelial cells and inhibited *induced* IKKalpha/beta phosphorylation , [IkappaB-alpha] degradation and IL-6 production in HUVEC . Positive_regulation NFKBIA TNF 18644347 1947741 however , Celecoxib had no effect on *induced* IKK activation and degradation of [IkappaBalpha] and IkappaBbeta , suggesting that it inhibited NF-kappaB activation via suppressing downstream of IKK activation and IkappaBs degradation . Positive_regulation NFKBIA TNF 18755353 1956456 Pioglitazone repressed endothelial *induced* VCAM-1 messenger ribonucleic acid expression and promoter activity , and induced hepatic [IkappaBalpha] in a manner dependent on both pioglitazone exposure and PPARalpha expression . Positive_regulation NFKBIA TNF 18952893 2034828 XN directly inhibited *induced* [IkappaBalpha kinase (IKK)] activation and a reducing agent abolished this inhibition , indicating the role of cysteine residue . Positive_regulation NFKBIA TNF 18975348 1983212 Inhibition of ROK by specific inhibitors or ROK small interfering RNA suppressed lipopolysaccharide- or *induced* NF-kappaB nuclear translocation , DNA binding activity , luciferase reporter gene expression , and [IkappaBalpha] degradation . Positive_regulation NFKBIA TNF 18981572 1983610 Rb1 also effectively blocked induced *activation* of p38 , c-Jun N-terminal protein kinase , extracellular signal regulated kinase 1/2 and [IkappaBalpha] . Positive_regulation NFKBIA TNF 19091594 2031051 Compared to those observed in wild-type MEFs , *induced* IkappaB kinase (IKK) activation and [IkappaBalpha] degradation were enhanced in TRAF6-deficient MEFs . Positive_regulation NFKBIA TNF 19135070 2031961 Both NMDA and *led* to the phosphorylation and degradation of [IkappaBalpha] , demonstrating that both agents can activate NF-kappaB in cerebellar granule cells . Positive_regulation NFKBIA TNF 19180958 2007110 However , the phosphorylation and subsequent degradation of [IKBalpha] *induced* by can not be inhibited in HL-60 cells even we prolonged the treatment time or increased the concentration of GhE . Positive_regulation NFKBIA TNF 19183881 2033286 Moreover , ACK significantly suppressed *induced* translocation of redox-sensitive nuclear factor (NF)-kappaB as well as degradation of cytosolic [I-kappaBalpha] . Positive_regulation NFKBIA TNF 19274442 2072833 Pep 3 ( LRENECVS ) which was derived from the hydrophilic region of A1 module in CRD4 remarkably inhibited the binding of TNF-alpha to TNF-R1 , and also reversed *induced* degradation of [IkappaB-alpha] and nuclear translocation of NF-kappaB p65 subunit in HeLa cells . Positive_regulation NFKBIA TNF 19277846 2106027 Sulforaphane had no effect on *induced* NF-kappaB nuclear binding activity , [IkappaB-alpha] degradation or activation of NF-kappaB-driven transcriptional activity . Positive_regulation NFKBIA TNF 19285159 2072933 *dependent* degradation of [IkappaBalpha] was also suppressed by overexpression of AWP1 and RIO3 , possibly due to the polyubiquitin binding activity of these proteins . Positive_regulation NFKBIA TNF 19410630 2089703 By transfection of TAK1 siRNA , *induced* phosphorylation of [IkappaBalpha] , JNK1/2 , and p38MAPK , as well as IL-6 or IL-8 expression , were repressed . Positive_regulation NFKBIA TNF 19429670 2106879 [IkappaB-alpha] phosphorylation was *enhanced* by , but not by Ang II . Positive_regulation NFKBIA TNF 19445900 2115289 Results obtained show that selected purified compounds had a cytotoxic effect on the human leukaemia cell line K562 , inhibited both TNF-alpha induced NF-kappaB-DNA binding as well as *induced* [IkappaBalpha] degradation and nuclear translocation of p50/p65 . Positive_regulation NFKBIA TNF 19472212 2102247 Interestingly , IFN-gamma alone had no effect on phosphorylation and degradation of IkappaB-alpha , whereas it significantly promoted *induced* phosphorylation and degradation of [IkappaB-alpha] . Positive_regulation NFKBIA TNF 19563733 2122000 EZS inhibited NF-kappaB activation and [IkappaB-alpha] phosphorylation *induced* by , subsequent degradation of IkappaB-alpha . Positive_regulation NFKBIA TNF 19665001 2125935 The proteasomal inhibitors MG132 , epoxomicin , lactacystin , and ALLN suppressed T0070907 mediated tubulin loss , although epoxomicin and lactacystin were less effective than MG132 , even at concentrations that completely inhibited *induced* [IkappaBalpha] degradation . Positive_regulation NFKBIA TNF 19683908 2231970 Magnolol suppressed the ratios of NF-kappaB to I-kappaBalpha protein contents and [I-kappaBalpha] phosphorylation *induced* by , and potentiated mitochondrial cytochrome c release and subsequent caspase-3 cleavage . Positive_regulation NFKBIA TNF 19733238 2147133 Finally , we showed that C/EBPbeta overexpression in HeLa cells blocked *mediated* inducibility of the [IkappaB-alpha] promoter . Positive_regulation NFKBIA TNF 19874889 2184465 Moreover , knockdown of USP11 expression enhances induced [IkappaBalpha] ubiquitination and NF-kappaB *activation* . Positive_regulation NFKBIA TNF 19877072 2160736 In sharp contrast , DEX did not affect *induced* IKK phosphorylation , [IkappaBalpha] degradation , p65 nuclear translocation , or MAPK activation in RA FLS . Positive_regulation NFKBIA TNF 19910690 2162142 EGCG suppressed the *induced* phosphorylation and degradation of [IkappaB-alpha] , thereby decreasing the phosphorylation and nuclear translocation of the NF-kappaB p65 subunit in HUVECs . Positive_regulation NFKBIA TNF 19959714 2204104 Despite normal IkBalpha degradation and polyubiquitination , FAT10 deficiency impaired *induced* [IkBalpha] degradation and nuclear translocation of p65 in RTECs , suggesting defective proteasomal degradation of polyubiquitinated IkBalpha . Positive_regulation NFKBIA TNF 19959714 2204107 Transduction of FAT10 ( -/- ) RTECs with FAT10 restored LMP2 expression , *induced* [IkBalpha] degradation , p65 nuclear translocation , and NF-kappaB activation . Positive_regulation NFKBIA TNF 19962318 2199494 Further characterization of SK2009 indicates that this newly synthesized molecule can suppress *induced* [IkappaBalpha] kinase activation and inhibit the expression of three NF-kappaB dependent gene products , cyclin D1 , Bcl-2 , and VEGF , in these cells . Positive_regulation NFKBIA TNF 20082310 2212589 Stimulation of myoblasts with *activated* IkappaB kinase alpha/beta ( IKKalpha/beta ) , [IkappaBalpha] phosphorylation , p65 phosphorylation , and kappaB-luciferase activity . Positive_regulation NFKBIA TNF 20138622 2280975 N-acetylcysteine , SP600125 , SB203580 and MPA had no effect on either *induced* [IkappaBalpha] degradation or p65 nuclear translocation , but attenuated p65 Ser276 phosphorylation . Positive_regulation NFKBIA TNF 20215516 2223444 It blocked *induced* [IkappaBalpha] phosphorylation , translocation of p65 , and expression of NF-kappaB regulated genes . Positive_regulation NFKBIA TNF 20302967 2273035 Treatment of the cells with *induced* phosphorylation and degradation of [IkappaBalpha] within 15 min . Positive_regulation NFKBIA TNF 20353766 2255176 The AT1 receptor blocker also decreased *induced* phosphorylation of [I kappaB alpha] and cell death . Positive_regulation NFKBIA TNF 20367887 2245061 Addition of MA inhibited *induced* [IkappaBalpha] degradation , p65 phosphorylation , and nuclear translocation . Positive_regulation NFKBIA TNF 20482842 2276175 Pristimerin blocked the *induced* [IkappaBalpha] phosphorylation , translocation of p65 , and expression of NF-kappaB regulated genes . Positive_regulation NFKBIA TNF 20484576 2288705 Moreover , endogenous activation of PLK1 reduces the *induced* phosphorylation of endogenous [IkappaBalpha] . Positive_regulation NFKBIA TNF 20503474 2263912 ABO inhibited the *induced* degradation of [IkappaB-alpha] , an inhibitor of NF-kappaB , by inhibiting the phosphorylation of IkappaB-alpha in HUVEC . Positive_regulation NFKBIA TNF 20816090 2314849 Surprisingly , hepatic IL-6Ralpha-disruption caused an exaggerated inflammatory response during euglycemic hyperinsulinemic clamp analysis , as revealed by increased expression of IL-6 , , and IL-10 , as well as enhanced *activation* of inflammatory signaling such as phosphorylation of [IkappaBalpha] . Positive_regulation NFKBIA TNF 21533395 479093 CAL-A ( 0.5 nM ) also augmented the *induced* phosphorylation of [I kappa B-alpha] , an inhibitor of NF-kappa B . Positive_regulation NFKBIA TNF 23982206 2833050 TCR- or *induced* expression of other NF-?B target genes , such as [NFKBIA] ( which encodes I?Ba ) and TNFAIP3 ( which encodes A20 ) , occurred independently of the O-GlcNAcylation of c-Rel . Positive_regulation NFKBIA TNF 7545393 318531 We show that pyrrolidine dithiocarbamate strongly reduces the *mediated* induction of E-selectin , VCAM-1 , ICAM-1 , PAI-1 , tissue factor , IL-8 and [I kappa B-alpha] . Positive_regulation NFKBIA TNF 7561050 324167 Serine protease inhibitors prevented the *induced* accumulation of phosphorylated [I kappa B-alpha] , and prevented I kappa B-alpha degradation and the appearance of NF-kappa B DNA binding activity . Positive_regulation NFKBIA TNF 7594468 334740 Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA induced IkB alpha phosphorylation/degradation irrespective of activation of Ca ( 2+ ) -dependent pathways , but not the phosphorylation and degradation of [IkB alpha] *induced* by , a PKC independent stimulus . Positive_regulation NFKBIA TNF 7594468 334741 Contrary to the interaction with PKC , Ca ( 2+ ) -dependent pathways *synergize* with not at the level of [IkB alpha] phosphorylation , but at the level of its degradation . Positive_regulation NFKBIA TNF 7629157 316643 However , *induction* of [I kappa B alpha] phosphorylation by both and the phosphatase inhibitors is associated with the subsequent degradation of I kappa B alpha . Positive_regulation NFKBIA TNF 7642544 317977 Treatment of cells with pervanadate inhibited *induced* [I kappa B-alpha] phosphorylation and degradation , whereas the serine protease inhibitors tosylphenylalanyl chloromethyl ketone and N alpha-p-tosyl-L-lysine chloromethyl ketone prevented TNF induced I kappa B-alpha degradation and NF-kappa B nuclear translocation , but not the TNF induced phosphorylation of I kappa B-alpha . Positive_regulation NFKBIA TNF 7796813 313812 While both endogenous and transiently expressed wild-type [I kappa B-alpha] were proteolytically degraded in *response* to PMA and stimulation of cells , the S32/36A mutant of I kappa B-alpha remained largely intact under these conditions . Positive_regulation NFKBIA TNF 7937093 276050 In transient assays , cotransfection with a p65 expression vector is able to activate an I kappa B-alpha promoter-CAT reporter construct and all three NF-kappa B sites are required for full *activation* of the [I kappa B-alpha] gene following stimulation with . Positive_regulation NFKBIA TNF 8622650 354386 ( ii ) serine residues located at positions 32 and 36 within the N-terminal region of I kappa B alpha represent major sites of induced phosphorylation ( substitution of these serine residues with alanine abrogates *induced* degradation of [I kappa B alpha] ) ; Positive_regulation NFKBIA TNF 8649809 364577 To explore the molecular mechanisms of signal induced depletion of IkappaBalpha , we have delineated the domain in IkappaBalpha that is required for *induced* phosphorylation and rapid degradation of [IkappaBalpha] . Positive_regulation NFKBIA TNF 8662753 367252 MEK kinase is involved in alpha *induced* NF-kappaB activation and degradation of [IkappaB-alpha] . Positive_regulation NFKBIA TNF 8799159 381942 CAPE prevented the translocation of the p65 subunit of NF-kappa B to the nucleus and had no significant effect on *induced* [I kappa B alpha] degradation , but did delay I kappa B alpha resynthesis . Positive_regulation NFKBIA TNF 9153285 431294 Prior induction of the stress response inhibited *mediated* dissociation of I-kappaBalpha from NF-kappaB and subsequent degradation of [I-kappaBalpha] . Positive_regulation NFKBIA TNF 9223587 442886 , but not OA , *activated* transcription factor nuclear factor-kappaB in methylcholanthrene-101 cells , as demonstrated by translocation of the nuclear factor-kappaB complex to the nucleus and disappearance of the cytoplasmic inhibitory protein , [IkappaB-alpha] . Positive_regulation NFKBIA TNF 9261113 448803 These compounds act by inhibiting *induced* phosphorylation of [IkappaB-alpha] , resulting in decreased nuclear factor-kappaB and decreased expression of adhesion molecules . Positive_regulation NFKBIA TNF 9374492 464881 Sanguinarine blocked the *induced* phosphorylation and degradation of [IkappaBalpha] , an inhibitory subunit of NF-kappaB , and inhibited translocation of p65 subunit to the nucleus . Positive_regulation NFKBIA TNF 9418855 480453 Activation of p38 mitogen activated protein kinase by sodium salicylate leads to inhibition of *induced* [IkappaB alpha] phosphorylation and degradation . Positive_regulation NFKBIA TNF 9418855 480490 We now show that inhibition of *induced* [IkappaB alpha] phosphorylation and degradation by NaSal is prevented by treatment of cells with SB203580 , a highly specific p38 MAPK inhibitor . Positive_regulation NFKBIA TNF 9418855 480492 Both p38 activation and inhibition of *induced* [IkappaB alpha] degradation were seen after only 30 s to 1 min of NaSal treatment . Positive_regulation NFKBIA TNF 9418855 480507 Induction of p38 MAPK activation and inhibition of *induced* [IkappaB alpha] degradation were demonstrated with pharmacologically achievable doses of NaSal . Positive_regulation NFKBIA TNF 9570554 501587 H2O2 pre-exposure effectively inhibited the PDBu- or *induced* phosphorylation and degradation of [I kappa B alpha] , but H2O2 given simultaneously with PDBu or TNF enhanced the degradation . Positive_regulation NFKBIA TNF 9573251 502358 [IkappaBalpha] proteolysis *induced* by occurred through the 26S proteasome , as both 26S proteasome activity and IkappaBalpha proteolysis were blocked by specific inhibitors lactacystin , MG-132 , and ZLLF-CHO . Positive_regulation NFKBIA TNF 9580637 504958 N-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) , a serine protease inhibitor , inhibited [I kappa B-alpha] degradation and NF-kappa B activation in *response* to in a dose dependent manner ( 25 , 50 , 100 microM ) . Positive_regulation NFKBIA TNF 9580637 504967 PAO ( 2.4 microM ) completely abolished activation of NF-kappa B and degradation of [I kappa B-alpha] *induced* by at a concentration that blocked PGHS-2 mRNA accumulation . Positive_regulation NFKBIA TNF 9593751 505866 Despite the presence of preactivated NF-kappaB , HuT-78 cells also expressed high levels of IkappaB-alpha , the inhibitory subunit of NF-kappaB and , unlike Jurkat cells , were resistant to *induced* degradation of [IkappaB-alpha] . Positive_regulation NFKBIA TNF 9624136 511362 , on the other hand , *stimulated* both [IkappaBalpha] degradation and p105 processing , in accordance with previous findings . Positive_regulation NFKBIA TNF 9679762 520883 The *induced* degradation of [IkappaB alpha] was also suppressed by ALLN treatment , thus implying that the molecule linking proteasome to MMP-9 production should be IkappaB alpha . Positive_regulation NFKBIA TNF 9710600 526823 Our studies now demonstrate that HTLV-1 Tax activates the recently identified cellular kinases IkappaB kinase alpha (IKKalpha) and IKKbeta , which normally phosphorylate [IkappaB alpha] on both of its N-terminal regulatory serines in *response* to and interleukin-1 (IL-1) stimulation . Positive_regulation NFKBIA TNF 9720648 528507 Examination of IkappaB alpha regulation revealed that *mediated* degradation of [IkappaB alpha] in both memory and naive T cells from the elderly was severely impaired , thus contributing to the lowered induction of the observed NFkappaB . Positive_regulation NFKBIA TNF 9743347 532404 Pretreatment of cells with IL-13 blocked *induced* NF-kappa B activation , nuclear translocation of p65 subunit , and degradation of [I kappa B alpha] . Positive_regulation NFKBIA TNF 9743602 532610 In contrast , rapidly *induced* [IkappaBalpha] degradation within 5 min and IkappaBbeta degradation within 15 min. Cycloheximide did not prevent LPS induced IkappaBalpha degradation , indicating that newly synthesized proteins induced by LPS were not involved in LPS stimulated IkappaBalpha degradation . Positive_regulation NFKBIA TNF 9759865 536582 However , while IL-1beta and both induced nuclear binding of the Rel proteins p50 and p65 to an NF-kappaB consensus oligonucleotide in gel shift assays and *caused* transient degradation of inhibitor of NF-kappaB-alpha ( [IkappaB-alpha] ) in the cytoplasm of myofibroblasts , only IL-1beta upregulated PDGF-Ralpha . Positive_regulation NFKBIA TNF 9792645 542607 Within the same time frame , *induced* c-Src associates with [Ikappa Balpha] in a long lived complex . Positive_regulation NFKBIA TNF 9891987 558603 Glucocorticoid treatment of cells did not result in elevated IkappaB-alpha expression , but impaired the *induced* degradation of [IkappaB-alpha] without affecting DNA binding of NF-kappaB . Positive_regulation NFKBIA TNF 9918798 559188 Similarly , stimulation of untransfected L929 cells with TGF-beta1 results in suppression of IkappaB-alpha expression and retarded [IkappaB-alpha] degradation in *response* to . Positive_regulation NFKBIA TNF 9927206 588476 However , taxol did not prevent *induced* [Ikappa-Balpha] phosphorylation , degradation , or NF-kappaB activation , indicating that TNF-alpha acts through a microtubule independent pathway . Positive_regulation NFKBIA TNFSF10 12807432 1101925 At later time points ( from 3 to 6 h onwards ) *induced* a progressive degradation of inhibitor of kappaB (IkappaB)beta and IkappaBepsilon , but not [IkappaBalpha] , coupled to the nuclear translocation of NF-kappaB and an increase in its DNA binding activity . Positive_regulation NFKBIA TNFSF10 20113484 2213124 Interestingly , knockdown of DR5 , but not DR4 , prevented *induced* [IkappaBalpha] and p-Akt reduction , suggesting that DR5 mediates reduction of IkappaBalpha and p-Akt induced by GGTI298/TRAIL . Positive_regulation NFKBIA TNFSF10 20451496 2275282 A pharmacological inhibitor of NF-kappaB , Bay 11-7082 , blocked *induced* NF-kappaB translocation to the nucleus and [IkappaBalpha] degradation . Positive_regulation NFKBIB EPHB2 14581482 1186937 Inhibition of did not affect interleukin-1beta induced I-kappaBalpha phosphorylation and degradation but *attenuated* [I-kappaBbeta] degradation . Positive_regulation NFKBIB IL1B 11742864 887444 [IkappaBbeta] , but not IkappaBalpha degradation , *induced* by was markedly attenuated when ERK activation was inhibited and could be partially responsible for the persistent NF-kappaB activation . Positive_regulation NFKBIB IL1B 12670873 1080134 TENS-L is a potent inhibitor of *induced* [I-kappaBbeta] degradation and prevents dissociation of NF-kB from cytoplasmic complexes and thus its nuclear translocation . Positive_regulation NFKBIB IL1B 16822942 1638580 In cultured rat VSMCs , *activated* ERK and induced degradation of both IkappaBalpha and [IkappaBbeta] , which was associated with nuclear translocation of both ribosomal S6 kinase (RSK)1 and NF-kappaB p65 . Positive_regulation NFKBIB IL1B 19370157 2058814 This suppression of NOS2 by DCS correlates with the attenuation of the NF-kappaB signaling pathway as measured by *induced* phosphorylation of the inhibitor of kappa B (IkappaB)-alpha , degradation of IkappaB-alpha and [IkappaB-beta] , and subsequent nuclear translocation of NF-kappaB p65 . Positive_regulation NFKBIB TNF 10428782 633246 We demonstrate that NaSal similarly inhibits *induced* [IkappaBbeta] degradation in a p38 dependent manner . Positive_regulation NFKBIB TNF 12121873 965128 mediated IKK activation *leads* to IkappaBalpha and [IkappaBbeta] degradation . Positive_regulation NFKBIB TNF 12153521 971462 We found that *causes* rapid degradation of IkappaBalpha and [IkappaBbeta] . Positive_regulation NFKBIB TNF 18644347 1947742 however , Celecoxib had no effect on *induced* IKK activation and degradation of IkappaBalpha and [IkappaBbeta] , suggesting that it inhibited NF-kappaB activation via suppressing downstream of IKK activation and IkappaBs degradation . Positive_regulation NFKBIB TNF 20353839 2273294 In addition we determined that treatment did not *induce* the degradation of [IkappaBbeta] as did OFF . Positive_regulation NFKBIB TNF 9038140 415338 The calyculin A-mediated degradation of [IkappaBbeta] is further *enhanced* by the cytokine , although TNF-alpha alone is unable to induce the degradation of IkappaBbeta . Positive_regulation NFKBIB TNF 9038140 415339 Mutational analyses have revealed that the inducible degradation of [IkappaBbeta] *induced* by calyculin A , and requires two N-terminal serines ( serines 19 and 23 ) that are homologous to the inducible phosphorylation sites present in IkappaBalpha . Positive_regulation NFKBIB TNF 9442374 475201 Here we show that in E29.1 T cell hybridoma I kappa B alpha and I kappa B beta are equally associated with p65 and that [I kappa B beta] is degraded in *response* to in contrast to what has been originally published . Positive_regulation NFKBIB TNF 9882379 584128 Furthermore , the HCV core protein enhanced or prolonged the [IkappaB-beta] degradation *triggering* by or LT-alpha1beta2 both in HeLa and HuH-7 cells . Positive_regulation NFKBIB TNFSF10 12807432 1101926 At later time points ( from 3 to 6 h onwards ) *induced* a progressive degradation of [inhibitor of kappaB (IkappaB)beta] and IkappaBepsilon , but not IkappaBalpha , coupled to the nuclear translocation of NF-kappaB and an increase in its DNA binding activity . Positive_regulation NFKBIE ANKRD1 11970947 953792 Similar to IkappaBalpha , nuclear import of [IkappaBepsilon] is *mediated* by its and is not blocked by the dominant negative RanQ69L protein . Positive_regulation NFKBIE TNFSF10 12807432 1101927 At later time points ( from 3 to 6 h onwards ) *induced* a progressive degradation of inhibitor of kappaB (IkappaB)beta and [IkappaBepsilon] , but not IkappaBalpha , coupled to the nuclear translocation of NF-kappaB and an increase in its DNA binding activity . Positive_regulation NFKBIZ IL1B 12565889 1054342 [I kappa B-zeta] , a new negative-regulator of nuclear factor-kappa B (NF-kappa B) , is strongly *induced* by lipopolysaccharide or stimulation , but not by tumor necrosis factor-alpha . Positive_regulation NFKBIZ IL1B 12831461 1105527 stimulation also *results* in the strong induction of [IkappaB-zeta] , but tumor necrosis factor-alpha does not . Positive_regulation NFKBIZ IL1B 16513645 1549179 Treatment with tumor necrosis factor-alpha , , and lipopolysaccharide *induced* a strong induction of [IkappaB-zeta] transcripts . Positive_regulation NFKBIZ IL1B 19502795 2098136 In HepG2 cells miR-124a was not endogenously expressed , but upon enforced expression dramatically inhibited the *induced* protein expression of [IkappaBzeta] . Positive_regulation NFKBIZ IL1B 19707556 2127264 [IkappaBzeta] is specifically *induced* by and several TLR ligands and positively regulates NFkappaB mediated transcription of genes such as IL-6 and NGAL as an NFkappaB binding co-factor . Positive_regulation NFKBIZ IL1B 19707556 2127267 Our results demonstrated that IL-18 , as well as , *induced* moderate [IkappaBzeta] expression in KG-1 cells . Positive_regulation NFKBIZ TLR7 15241416 1270531 Transcription of [IkappaBzeta] is rapidly induced by *stimulation* with ligands and interleukin-1 (IL-1) . Positive_regulation NFKBIZ TLR7 19707556 2127259 [IkappaBzeta] is specifically *induced* by IL-1beta and several ligands and positively regulates NFkappaB mediated transcription of genes such as IL-6 and NGAL as an NFkappaB binding co-factor . Positive_regulation NFKBIZ TNF 12565889 1054341 [I kappa B-zeta] , a new negative-regulator of nuclear factor-kappa B (NF-kappa B) , is strongly *induced* by lipopolysaccharide or interleukin-1 beta stimulation , but not by . Positive_regulation NFKBIZ TNF 20220144 2249436 As IL-17 stimulation stabilizes the IkappaB-zeta transcript , we propose a model where induces activation and binding of NF-kappaB to the promoters of both NFKBIZ and LCN2 genes but *induce* only transcription of [IkappaB-zeta] . Positive_regulation NFYA FAS 11530940 853813 The FIRE3 mediated sterol response of the promoter *requires* [NF-Y/CBF] as a coactivator . Positive_regulation NFYB FAS 11530940 853814 The FIRE3 mediated sterol response of the promoter *requires* [NF-Y/CBF] as a coactivator . Positive_regulation NFYC FAS 11530940 853815 The FIRE3 mediated sterol response of the promoter *requires* [NF-Y/CBF] as a coactivator . Positive_regulation NGF ADRB2 9349525 460767 Using a human cell line , ODM-2 , derived from the nonpigmented ciliary epithelium , we demonstrate that ( 1 ) NT expression is highly activated by [nerve growth factor] , glucocorticoid , and activators of adenylate cyclase; (2) NTr expression is *up-regulated* by selective ligand activated ; Positive_regulation NGF CABP4 1511283 196598 [Nerve growth factor] *increases* ( calbindin-D28K ) in rat olfactory bulb . Positive_regulation NGF CCL17 21521373 2449093 *enhanced* [nerve growth factor (NGF)] production by 2B4 , which is mouse T cell hybridoma . Positive_regulation NGF CCND1 9236224 445599 [Nerve growth factor] *induces* transcription of the p21 WAF1/CIP1 and genes in PC12 cells by activating the Sp1 transcription factor . Positive_regulation NGF CCND1 9236224 445606 We have shown previously ( ) that [NGF] *induces* the expression of the p21 WAF1/CIP1/Sdi1 ( p21 ) cyclin dependent kinase (Cdk) inhibitor protein and the G1 phase cyclin , . Positive_regulation NGF EDN2 10626070 576250 5 . *enhances* the activity of [nerve growth factor] and modulates the release of neurotransmitter from post-ganglionic sympathetic nerve terminals . Positive_regulation NGF EDN2 8417145 210430 The activation of protein kinase C appears as an obligatory step during these processes , because ( a ) inhibition of protein kinase C by staurosporine blocks the *induction* by or phorbol esters of both c-fos and [nerve growth factor] , and ( b ) phorbol ester evoked down-regulation of protein kinase C completely abolishes the c-fos induction by endothelin , but not that by the beta-adrenergic agonist isoproterenol , a known activator of the cyclic AMP dependent pathway . Positive_regulation NGF EPHB2 10772818 686260 Both TPA and [NGF] *induced* a sustained activation and nuclear accumulation of that was accompanied by transactivation of a serum response element ( SRE ) -driven reporter and of the c-fos gene . Positive_regulation NGF EPHB2 12706116 1082491 In PC12 cells , [NGF] and EGF *induce* a rapid translocation of that requires Ras and Mek . Positive_regulation NGF EPHB2 15028221 1222958 For example , the mitogen EGF induces a transient ERK activation , whereas the neurotrophin [NGF] *induces* prolonged activation . Positive_regulation NGF EPHB2 16337149 1503854 In the *presence* of inhibitor , PD98059 , the generation of [beta-NGF] was diminished in a dose dependent manner consistent with the inhibiting effect on neuronal differentiation . Positive_regulation NGF EPHB2 17111371 1667748 [NGF] *induced* persistent and AP-1 activities , whereas upon EGF and anisomycin exposures , their activities were only weakly and transiently induced . Positive_regulation NGF EPHB2 18299325 1903877 Importantly , [proNGF] activates TrkA tyrosine phosphorylation , *induces* and Akt activation , and causes PC12 cell differentiation . Positive_regulation NGF EPHB2 19557513 2182717 However , the neurite outgrowth activity and the [NGF] and BDNF release induced by 4-O-methylhonokiol are *suppressed* by an inhibitor . Positive_regulation NGF EPHB2 20868677 2337197 However , the neurite outgrowth , and [NGF] and BDNF release induced by obovatol were *prevented* by an inhibitor . Positive_regulation NGF EPHB2 9390997 467687 Taken together , these data indicate that MEK and may be critically *involved* in protein kinase C and [nerve growth factor] regulation of APP processing . Positive_regulation NGF EPHB2 9706879 526341 [NGF] *induces* transient but not sustained activation of in PC12 mutant cells incapable of differentiating . Positive_regulation NGF F2R 8632154 361548 Transduction mechanisms involved in *induced* [nerve growth factor] secretion and cell division in primary cultures of astrocytes . Positive_regulation NGF FAS 18692025 1984781 [Nerve growth factor (NGF)] dose-dependently *induced* sprouting and the expression of the NGF receptors Trk tyrosine kinase receptor (TrkA) and p75 neurotrophin receptor ( p75 ( NTR ) ) as well as and Fas ligand . Positive_regulation NGF FOXO1 12913110 1129594 Finally , we show that activity *contributes* to the [NGF] deprivation induced death of sympathetic neurons . Positive_regulation NGF FOXO1 21549807 2440470 Our data demonstrated that [NGF] could *induce* the nuclear exclusion of and FoxO3a-GFP in PC12 cells with different properties , but had no effect on FoxO6-GFP 's nuclear localization and FoxO6-GFP showed an exclusive nuclear localization . Positive_regulation NGF IL1B 11286158 799860 Astrocytes can express NGF , and IL-1 alpha or can *enhance* the [NGF] expression in newborn rat astrocytes . Positive_regulation NGF IL1B 11689196 876124 Stimulation by for 24 h *induced* a dose dependent increase in [NGF] production ( maximal at 10 U/ml with 59.6+/-3.5 % increase , P < 0.05 ) . Positive_regulation NGF IL1B 11771938 899297 RT-PCR analysis demonstrated that CNTF increased levels of FGF-2 and nerve growth factor (NGF) mRNA and that *increased* [NGF] and hepatocyte growth factor mRNA levels . Positive_regulation NGF IL1B 12212982 984240 Stimulation with ( 0.1-30 U x mL(-1) ) for 24 h *induced* a dose dependent increase in [NGF] production ( 22.1 pg x mL(-1) at 10 U x mL(-1) ; p < 0.05 ) . Positive_regulation NGF IL1B 1333537 204440 We have investigated possible mechanisms by which *regulates* [NGF] in hippocampal cells . Positive_regulation NGF IL1B 1446245 205284 *stimulated* [NGF] secretion from astrocytes , and the magnitude of this secretion was decreased in the co-cultures . Positive_regulation NGF IL1B 14611111 1162778 Both and TNF-alpha , but not CCK-8 *promote* [NGF] synthesis and release from OA cells . Positive_regulation NGF IL1B 15994384 1429806 ( 10 ng x mL(-1) ; 21 degrees C; 15 h ) *increased* the release of [NGF] from human isolated bronchi in vitro , and , in organ bath studies , the response of human bronchi to [ Sar9,Met ( O2 ) 11 ] -substance P ( 0.1 microm ) . Positive_regulation NGF IL1B 16441896 1527872 *stimulated* a transient increase of [NGF] , while the increase of BDNF had a later onset and was more sustained . Positive_regulation NGF IL1B 16441896 1527874 COX-inhibitors ( indomethacin and NS-398 ) markedly decreased *stimulated* secretion of BDNF , but not IL-1beta stimulated [NGF] secretion . Positive_regulation NGF IL1B 16441896 1527877 IFN-gamma increased NGF expression , down-regulated BDNF expression and synergistically enhanced *stimulated* [NGF] expression . Positive_regulation NGF IL1B 16441896 1527878 In contrast , IL-4 had no effect on basal NGF and BDNF expression , but decreased *stimulated* [NGF] expression . Positive_regulation NGF IL1B 1708303 155105 Epidermal growth factor (EGF) , , and tumor necrosis factor-alpha (TNF-alpha) also *increased* [NGF] secretion by astrocytes to a certain extent . Positive_regulation NGF IL1B 17121704 1652222 The HHKs component in the artificial nerve bridge underwent degradation in the sciatic nerve defect after 3 to 4 weeks , and activation *resulted* in enhanced [NGF] expression in the SCs . Positive_regulation NGF IL1B 17306250 1705143 This study suggests tachykininergic sensory nerves to be involved in the *induced* [NGF] release and airway hyperresponsiveness . Positive_regulation NGF IL1B 17413467 1722438 and TNF-alpha *up-regulated* the [NGF] mRNA expression and the secretion of NGF protein into the media . Positive_regulation NGF IL1B 18300262 1896779 NF-kappaB activity , but not AP-1 , increased significantly under hyperosmolar conditions , and NF-kappaB was involved in *induced* [NGF] production . Positive_regulation NGF IL1B 18300262 1896786 *induced* [NGF] production reduced JNK phosphorylation and HCEC apoptosis . Positive_regulation NGF IL1B 18727839 1979960 In cultured human nucleus pulposus cells , stimulation with *led* to significant increases in [NGF] and BDNF gene expression ( P < 0.05 ) . Positive_regulation NGF IL1B 19177265 2061155 FACS studies showed that unstimulated FLS expressed low levels of NGF and the high-affinity NGF-tyrosine kinase receptor TrkA , and TNFalpha and *increased* [NGF] and TrkA expression in FLS . Positive_regulation NGF IL1B 2094822 149976 and tumor necrosis factor-alpha synergistically *stimulate* [nerve growth factor (NGF)] release from cultured rat astrocytes . Positive_regulation NGF IL1B 22853041 2682386 *upregulates* brain derived neurotrophic factor , neurotrophin 3 and neuropilin 2 gene expression and [NGF] production in annulus cells . Positive_regulation NGF IL1B 7867748 287364 We infused IL-1 beta into the ventricle of adult rats and found a two- to fourfold increase in NGF in the cerebral cortex , hippocampus , and cerebellum , suggesting that induced in vivo may also *increase* [NGF] in the brain . Positive_regulation NGF IL1B 8554509 339992 We found that co-stimulation of rat glomerular mesangial cells with platelet derived growth factor ( PGDF-BB ) and IL-1 beta/TNF-alpha significantly augments the *induced* NGF mRNA levels and [NGF] synthesis . Positive_regulation NGF IL1B 8572657 349920 The increase in NGF temporally follows the increase in IL-1 beta , suggesting that the up-regulation after trauma directly *induces* the increase in [NGF] . Positive_regulation NGF IL1B 8635583 362071 Treatment of the cells with a combination of anti-TNF-R2 antibody and interleukin-1 beta (IL-1 beta) does not increase the [NGF] production *induced* by alone , although TNF 's activity to stimulate NGF production is markedly enhanced by IL-1 beta . Positive_regulation NGF IL1B 9179382 434355 A key participant is the *induction* of the neurotrophin [nerve growth factor (NGF)] by . Positive_regulation NGF IL1B 9202299 440028 Calcitriol stimulated NGF secretion , whereas corticosterone reduced basal levels of NGF secretion as well as inhibited the [NGF] secretion *induced* by , calcitriol , and TGF-beta1 . Positive_regulation NGF IL1B 9833249 552014 *Role* of and TNF-alpha in the regulation of [NGF] in experimentally induced arthritis in mice . Positive_regulation NGF IL1B 9833249 552023 Out data showed that , but not TNF-alpha , induces an *increase* in [NGF] levels , while concomitant injection of both cytokines enhances the effect of IL-1 beta on NGF presence . Positive_regulation NGF IL6R 8858917 388466 [NGF] also *induced* expression of the subunit of the IL-6 receptor , providing another potential mechanism of cooperativity between NGF and IL-6 signaling . Positive_regulation NGF MAP2K6 11885780 894134 The inductions of BDNF and [NGF] were also *blocked* by inhibitors of p38 and , as well as by the inhibition of NF-kappaB with a decoy DNA sequence . Positive_regulation NGF MMP7 22238106 2538013 *regulates* cleavage of [pro-nerve growth factor] and is neuroprotective following kainic acid induced seizures . Positive_regulation NGF NGFR 11000524 734520 [NGF] also *induced* the expression of the p75 . Positive_regulation NGF NGFR 15703394 1372674 We show here that [nerve growth factor] can *induce* the release of and facilitate its translocation to the nucleus in a gamma-secretase dependent manner . Positive_regulation NGF NGFR 1850821 155672 High-affinity [NGF] binding *requires* coexpression of the trk proto-oncogene and the low-affinity . Positive_regulation NGF NGFR 1850821 155674 Reconstitution experiments by membrane fusion and transient transfection into heterologous cells indicate that high-affinity [NGF] binding *requires* coexpression and binding to both the low-affinity and the tyrosine kinase trk gene product . Positive_regulation NGF NGFR 1963076 147859 Since the biological activity of [NGF] is *mediated* by the , we hypothesized that defects in the NGF/NGFR pathway may play a role in maintenance of the undifferentiated state of neuroblastomas . Positive_regulation NGF NGFR 8022812 263159 In this study we demonstrate , in vitro , that lowering the levels of expression in sensory neurons with antisense oligonucleotides largely prevents the NGF mediated survival of sensory neurons from embryonic day 12 and 15 mice but *increases* the survival of embryonic day 19 and postnatal day 2 sensory neurons in the absence of [NGF] . Positive_regulation NGF NGFR 8027574 263564 By contrast , keratinocyte proliferation is not inhibited by an anti-low-affinity NGF-R monoclonal antibody , thus suggesting that [NGF] effect on human keratinocytes is *mediated* by the high-affinity . Positive_regulation NGF NGFR 8698038 372879 The *role* of the low affinity ( p75 ( NGFR ) ) in [NGF] mediated signaling is not yet understood . Positive_regulation NGF NGFR 8787152 371463 The expressed on Schwann cells could *mediate* [NGF] to support and induce the axon regeneration in the central nervous system . Positive_regulation NGF NGFR 8955210 401366 It is , however , unknown whether other homologous neurotrophins also act outside the nervous system , and whether activation of basophils by [NGF] *requires* interaction with trk tyrosine kinase receptors , the low affinity ( LNGFR ) , or both . Positive_regulation NGF NGFR 9038213 415417 These results suggest that the [NGF] effect is *mediated* by the high affinity , Trk A and that neurotrophin binding to the low affinity neurotrophin receptor , p75(NTR) , alone does not affect the promoter activity . Positive_regulation NGF NGFR 9406817 470437 These findings show that autocrine [NGF] *acts* as a survival factor for human keratinocytes in vitro through its high-affinity , possibly by maintaining constant levels of Bcl-2 . Positive_regulation NGF PLAU 10905620 713694 [NGF] preferentially *induces* the receptor in PC12 cells . Positive_regulation NGF SPHK1 16135093 1474853 [NGF] *induced* an increase in enzyme activity and protein about double those in PC12 cells , and NGF induced SPHK1 mRNA was three times higher than in the control . Positive_regulation NGF STK39 17305717 1699129 In addition , SB225002 , a G-protein coupled receptor antagonist , and staurosporine , a inhibitor , partially *inhibited* TGF-beta1 mediated induction of [NGF] . Positive_regulation NGF TNF 14611111 1162776 Both interleukin-1-beta (IL-1 beta) and , but not CCK-8 *promote* [NGF] synthesis and release from OA cells . Positive_regulation NGF TNF 15562246 1380590 MCP-1 and [NGF] secretion *increased* 8- to 10-fold with , whereas leptin and adiponectin did not change . Positive_regulation NGF TNF 16586095 1574804 In contrast , induced rapid and substantial *increases* in expression of the genes encoding IL-6 , MCP-1 , [NGF] and TNF-alpha itself ; Positive_regulation NGF TNF 16586095 1574807 IL-6 ( transiently ) , MCP-1 , [NGF] and VEGF release were *stimulated* by , with an accelerating rate of MCP-1 secretion over 24 h . TNF-alpha has rapid and substantial effects on the synthesis of key inflammation related adipokines in human adipocytes , with highly gene-specific responses . Positive_regulation NGF TNF 16956589 1627642 The *role* of and its receptors in the production of [NGF] and GDNF by astrocytes . Positive_regulation NGF TNF 16956589 1627648 In addition , we observe that not only exogenous but also TNF-alpha produced by astrocytes *induce* [NGF] and GDNF production in astrocytes . Positive_regulation NGF TNF 1708303 155103 Epidermal growth factor (EGF) , interleukin-1 beta (IL-1 beta) , and also *increased* [NGF] secretion by astrocytes to a certain extent . Positive_regulation NGF TNF 17413467 1722437 IL-1beta and *up-regulated* the [NGF] mRNA expression and the secretion of NGF protein into the media . Positive_regulation NGF TNF 18094051 1869022 We find that [NGF] can *induce* synthesis through the nuclear factor-kappaB transcription factor . Positive_regulation NGF TNF 18792883 1986431 The proinflammatory cytokine also *led* to a substantial increase in [NGF] mRNA levels ( 11-fold ) and protein secretion ( 16-fold ) , while IL-6 had little effect . Positive_regulation NGF TNF 19177265 2061154 FACS studies showed that unstimulated FLS expressed low levels of NGF and the high-affinity NGF-tyrosine kinase receptor TrkA , and and IL-1beta *increased* [NGF] and TrkA expression in FLS . Positive_regulation NGF TNF 19942804 2172309 Inflammatory cytokine *enhances* [nerve growth factor] production in human keratinocytes , HaCaT cells . Positive_regulation NGF TNF 19942804 2172310 Here , we show that , but not interferon-gamma or interleukin-6 , *enhanced* the [NGF] production in human keratinocytes . Positive_regulation NGF TNF 19942804 2172313 These results indicate that *enhances* [NGF] production via the Raf-1 / MEK / ERK pathway in human keratinocytes , suggesting that regulating TNF-alpha is a therapeutic target to control NGF production and subsequent sensory innervations . Positive_regulation NGF TNF 20133718 2213537 Consistent with this , we show that [proNGF] *induced* robust expression of in Müller cells and that genetic or biochemical ablation of TNFalpha blocked proNGF induced death of retinal neurons . Positive_regulation NGF TNF 20350782 2244903 Induction of [NGF] in the post-operative phase of pain was *dependent* as anti-TNF reduced NGF expression in the joint and abrogated pain . Positive_regulation NGF TNF 20690185 2368111 IL-1ß and *stimulated* the gene expression of VEGF , [NGF] , and BDNF in nucleus pulposus ( NP ) cells isolated from patient tissues . Positive_regulation NGF TNF 2094822 149975 Interleukin-1 beta and synergistically *stimulate* [nerve growth factor (NGF)] release from cultured rat astrocytes . Positive_regulation NGF TNF 22351621 2624269 We investigated the effects of low-level laser on the accumulation of HIF-1a , , and interleukin-1ß (IL-1ß) in controlling neuropathic pain , as well as on the *activation* of vascular endothelial growth factor ( VEGF ) and [nerve growth factor (NGF)] in promoting functional recovery in a rat CCI model . Positive_regulation NGF TNF 24289989 2904653 Dienogest inhibits [nerve growth factor] expression *induced* by or interleukin-1ß . Positive_regulation NGF TNF 24289989 2904680 In immortalized hEECs , [NGF] production *induced* by or interleukin-1ß (IL-1ß) was evaluated in the presence or absence of the synthetic progestin DNG or endogenous P . Positive_regulation NGF TNF 8428934 212637 *stimulates* the synthesis and secretion of biologically active [nerve growth factor] in non-neuronal cells . Positive_regulation NGF TNF 8428934 212638 *stimulates* the synthesis and secretion of [NGF] also in other cells such as human glioblastoma cells . Positive_regulation NGF TNF 8554509 339991 We found that co-stimulation of rat glomerular mesangial cells with platelet derived growth factor ( PGDF-BB ) and IL-1 beta/TNF-alpha significantly augments the IL-1 *induced* [NGF] mRNA levels and NGF synthesis . Positive_regulation NGF TNF 8843146 387359 Moreover , INF-gamma completely inhibited the increase in NGF secretion induced by IL-10 whereas it had no effect on the *induction* of [NGF] by . Positive_regulation NGF TNF 9681439 521151 Evidence for the lack of involvement of sphingomyelin hydrolysis in the *induced* secretion of [nerve growth factor] in primary astrocyte cultures . Positive_regulation NGF TNF 9681439 521152 Because ceramide is also able to induce NGF secretion and because TNF alpha is a known agonist of the sphingomyelin ( SPM ) -ceramide pathway , we investigated whether the *induced* [NGF] secretion by primary astrocytes is mediated by ceramide . Positive_regulation NGF TNF 9681439 521165 Altogether , our data strongly suggest that *mediated* up-regulation of [NGF] occurs independently of ceramide generation . Positive_regulation NGF TNF 9833249 552013 *Role* of IL-1 beta and in the regulation of [NGF] in experimentally induced arthritis in mice . Positive_regulation NGF TNF 9833249 552022 Out data showed that IL-1 beta , but not , induces an *increase* in [NGF] levels , while concomitant injection of both cytokines enhances the effect of IL-1 beta on NGF presence . Positive_regulation NGFR BLNK 22880054 2641711 [NGFR-LMP1] signaling *induces* phosphorylation of , a marker of Syk activation . Positive_regulation NGFR CEP104 15525794 1367309 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP112 15525794 1367321 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP120 15525794 1367319 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP128 15525794 1367307 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP135 15525794 1367325 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP152 15525794 1367327 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP164 15525794 1367326 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP170 15525794 1367322 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP19 15525794 1367320 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP192 15525794 1367312 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP250 15525794 1367306 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP290 15525794 1367323 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP350 15525794 1367308 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP41 15525794 1367305 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP44 15525794 1367328 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP55 15525794 1367304 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP57 15525794 1367330 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP63 15525794 1367316 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP68 15525794 1367324 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP70 15525794 1367329 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP72 15525794 1367313 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP76 15525794 1367314 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP78 15525794 1367315 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP85 15525794 1367311 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP89 15525794 1367317 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP95 15525794 1367310 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CEP97 15525794 1367318 In the cell culture model of nerve growth factor (NGF) deprived sympathetic neurons , we find that *induced* a approximately 3-fold increase in the mRNA and protein levels of TrkA , the [NGF receptor] . Positive_regulation NGFR CNTF 10446331 636553 *enhances* the expression of NGF and p75 low-affinity [NGF receptor] in astrocytes . Positive_regulation NGFR CNTF 1309648 178321 prevents neuronal degeneration and *promotes* low affinity [NGF receptor] expression in the adult rat CNS . Positive_regulation NGFR CNTF 1309648 178322 is also *involved* in up-regulation of immunostainable low affinity [NGF receptor] ( LNGFR ) in cholinergic medial septum and neostriatal neurons and in a population of lateral septum neurons . Positive_regulation NGFR CNTF 8227315 235611 caused morphological changes , *induced* the expression of low-affinity [nerve growth factor receptor] and CD4 and increased the expression of complement receptor 3 . Positive_regulation NGFR EGR1 8846003 337982 The zinc finger is *essential* for Schwann cell expression of the p75 [NGF receptor] . Positive_regulation NGFR FGF1 2155007 129343 Thus , the development of sympathetic neurons may involve a relay , in which both initiates differentiation and *induces* the [NGF receptor] , which in turn controls further maturation and survival . Positive_regulation NGFR FGF1 2847094 98887 Whereas the *induction* of the [NGF-R] by NGF and were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR FGF10 2155007 129344 Thus , the development of sympathetic neurons may involve a relay , in which both initiates differentiation and *induces* the [NGF receptor] , which in turn controls further maturation and survival . Positive_regulation NGFR FGF10 2847094 98888 Whereas the *induction* of the [NGF-R] by NGF and were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR FGF11 2155007 129345 Thus , the development of sympathetic neurons may involve a relay , in which both initiates differentiation and *induces* the [NGF receptor] , which in turn controls further maturation and survival . Positive_regulation NGFR FGF11 2847094 98889 Whereas the *induction* of the [NGF-R] by NGF and were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR FGF12 2155007 129346 Thus , the development of sympathetic neurons may involve a relay , in which both initiates differentiation and *induces* the [NGF receptor] , which in turn controls further maturation and survival . Positive_regulation NGFR FGF12 2847094 98890 Whereas the *induction* of the [NGF-R] by NGF and were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR FGF13 2155007 129347 Thus , the development of sympathetic neurons may involve a relay , in which both initiates differentiation and *induces* the [NGF receptor] , which in turn controls further maturation and survival . Positive_regulation NGFR FGF13 2847094 98891 Whereas the *induction* of the [NGF-R] by NGF and were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR FGF14 2155007 129348 Thus , the development of sympathetic neurons may involve a relay , in which both initiates differentiation and *induces* the [NGF receptor] , which in turn controls further maturation and survival . Positive_regulation NGFR FGF14 2847094 98892 Whereas the *induction* of the [NGF-R] by NGF and were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR FGF16 2155007 129349 Thus , the development of sympathetic neurons may involve a relay , in which both initiates differentiation and *induces* the [NGF receptor] , which in turn controls further maturation and survival . Positive_regulation NGFR FGF16 2847094 98893 Whereas the *induction* of the [NGF-R] by NGF and were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR FGF17 2155007 129350 Thus , the development of sympathetic neurons may involve a relay , in which both initiates differentiation and *induces* the [NGF receptor] , which in turn controls further maturation and survival . Positive_regulation NGFR FGF17 2847094 98894 Whereas the *induction* of the [NGF-R] by NGF and were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR FGF18 2155007 129351 Thus , the development of sympathetic neurons may involve a relay , in which both initiates differentiation and *induces* the [NGF receptor] , which in turn controls further maturation and survival . Positive_regulation NGFR FGF18 2847094 98895 Whereas the *induction* of the [NGF-R] by NGF and were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR FGF19 2155007 129352 Thus , the development of sympathetic neurons may involve a relay , in which both initiates differentiation and *induces* the [NGF receptor] , which in turn controls further maturation and survival . Positive_regulation NGFR FGF19 2847094 98896 Whereas the *induction* of the [NGF-R] by NGF and were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR FGF2 11112435 757633 This cellular differentiation was evidenced by *induced* expression of the human runt homologue AML1 ( PEBP2 alpha B , CBFA-2 ) that is highly expressed in developing olfactory neuroepithelium and TrkA , a preferred [nerve growth factor receptor] . Positive_regulation NGFR FGF2 1314950 185367 *enhances* [nerve growth factor receptor] gene promoter activity in human neuroblastoma cell line CHP100 . Positive_regulation NGFR FGF2 1314950 185370 also *increased* [p75NGFR] immunoreactivity , as assessed by immunocytochemistry , and increased p75NGFR mRNA levels , as assessed by Northern ( RNA ) blot analysis . Positive_regulation NGFR FGF2 2155007 129353 Thus , the development of sympathetic neurons may involve a relay , in which both initiates differentiation and *induces* the [NGF receptor] , which in turn controls further maturation and survival . Positive_regulation NGFR FGF2 2847094 98897 Whereas the *induction* of the [NGF-R] by NGF and were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR FGF2 9308005 454542 Furthermore , *induced* expression of the high affinity [NGF receptor] ( trkA ) gene . Positive_regulation NGFR FGF20 2155007 129354 Thus , the development of sympathetic neurons may involve a relay , in which both initiates differentiation and *induces* the [NGF receptor] , which in turn controls further maturation and survival . Positive_regulation NGFR FGF20 2847094 98898 Whereas the *induction* of the [NGF-R] by NGF and were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR FGF21 2155007 129355 Thus , the development of sympathetic neurons may involve a relay , in which both initiates differentiation and *induces* the [NGF receptor] , which in turn controls further maturation and survival . Positive_regulation NGFR FGF21 2847094 98899 Whereas the *induction* of the [NGF-R] by NGF and were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR FGF22 2155007 129356 Thus , the development of sympathetic neurons may involve a relay , in which both initiates differentiation and *induces* the [NGF receptor] , which in turn controls further maturation and survival . Positive_regulation NGFR FGF22 2847094 98900 Whereas the *induction* of the [NGF-R] by NGF and were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR FGF23 2155007 129357 Thus , the development of sympathetic neurons may involve a relay , in which both initiates differentiation and *induces* the [NGF receptor] , which in turn controls further maturation and survival . Positive_regulation NGFR FGF23 2847094 98901 Whereas the *induction* of the [NGF-R] by NGF and were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR FGF3 2155007 129358 Thus , the development of sympathetic neurons may involve a relay , in which both initiates differentiation and *induces* the [NGF receptor] , which in turn controls further maturation and survival . Positive_regulation NGFR FGF3 2847094 98902 Whereas the *induction* of the [NGF-R] by NGF and were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR FGF4 2155007 129359 Thus , the development of sympathetic neurons may involve a relay , in which both initiates differentiation and *induces* the [NGF receptor] , which in turn controls further maturation and survival . Positive_regulation NGFR FGF4 2847094 98903 Whereas the *induction* of the [NGF-R] by NGF and were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR FGF5 2155007 129360 Thus , the development of sympathetic neurons may involve a relay , in which both initiates differentiation and *induces* the [NGF receptor] , which in turn controls further maturation and survival . Positive_regulation NGFR FGF5 2847094 98904 Whereas the *induction* of the [NGF-R] by NGF and were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR FGF6 2155007 129361 Thus , the development of sympathetic neurons may involve a relay , in which both initiates differentiation and *induces* the [NGF receptor] , which in turn controls further maturation and survival . Positive_regulation NGFR FGF6 2847094 98905 Whereas the *induction* of the [NGF-R] by NGF and were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR FGF7 2155007 129362 Thus , the development of sympathetic neurons may involve a relay , in which both initiates differentiation and *induces* the [NGF receptor] , which in turn controls further maturation and survival . Positive_regulation NGFR FGF7 2847094 98906 Whereas the *induction* of the [NGF-R] by NGF and were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR FGF8 2155007 129363 Thus , the development of sympathetic neurons may involve a relay , in which both initiates differentiation and *induces* the [NGF receptor] , which in turn controls further maturation and survival . Positive_regulation NGFR FGF8 2847094 98907 Whereas the *induction* of the [NGF-R] by NGF and were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR FGF9 2155007 129364 Thus , the development of sympathetic neurons may involve a relay , in which both initiates differentiation and *induces* the [NGF receptor] , which in turn controls further maturation and survival . Positive_regulation NGFR FGF9 2847094 98908 Whereas the *induction* of the [NGF-R] by NGF and were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR FYN 22880054 2641723 Whereas Src kinases are often required for Syk activation , we show here that PI3K/Akt activation and autocrine IL-10 production by [NGFR-LMP1] *involves* the Src family kinase . Positive_regulation NGFR HRAS 9215709 441815 Together , these results suggest that [NGF receptor] tyrosine kinase *activation* of is likely to be involved in the tonic regulation of VDCCs in DRG neurons . Positive_regulation NGFR HRAS 9215709 441816 This effect appears largely to involve [NGF receptor] tyrosine kinase *activation* of . Positive_regulation NGFR MAPK3 15145933 1273203 Autophosphorylation of [NGF receptor] TrkA and *activation* of after NGF treatment were scarcely detected in GM1+ cells . Positive_regulation NGFR NGF 11000524 734521 also *induced* the expression of the p75 [NGF receptor] . Positive_regulation NGFR NGF 1314657 185015 *stimulated* tyrosine phosphorylation of the pp140c-trk [NGF receptor] and tyrosine phosphorylation of pp70trk are also inhibited by similar concentrations of staurosporine and K252A , whereas tyrosine phosphorylation of the EGF receptor , insulin receptor , and v-src is not affected . Positive_regulation NGFR NGF 1319504 190019 More importantly , administration of dexamethasone appears to block the *mediated* induction of [NGFR] when both agents are administered simultaneously . Positive_regulation NGFR NGF 1337936 208044 *mediated* up-regulation of low-affinity [NGF receptor] gene expression in cultured basal forebrain cholinergic neurons from postnatal 3-day-old rats . Positive_regulation NGFR NGF 14991458 1215463 The delivery of sufficient amounts of NGF signal to BFCN cell bodies depends on the effective participation of several factors including sufficient synthesis and release of NGF , adequate synthesis and expression of NGF receptors by BFCNs , normal signaling and retrograde transport of [NGF-receptor] complex , and finally effective *induction* of gene expression by . Positive_regulation NGFR NGF 15703394 1372675 We show here that can *induce* the release of [p75ICD] and facilitate its translocation to the nucleus in a gamma-secretase dependent manner . Positive_regulation NGFR NGF 1660904 171503 A pronounced *induced* increase of [nerve growth factor receptor-like] immunoreactivity was also observed in central regions innervated by trigeminal and spinal ganglia . Positive_regulation NGFR NGF 1660904 171504 In contrast , treatment did not *induce* appreciable modification of [nerve growth factor receptor-like] immunoreactivity in cerebellar , brainstem , and spinal motor structures of newborn rats . Positive_regulation NGFR NGF 1660904 171505 Finally , was also found to *enhance* , in both adult and newborn rats , [nerve growth factor receptor-like] immunoreactivity associated with ependymal and subependymal cellular elements of the lateral and third ventricles , as well as with the leptomeninges overlying the superior colliculus and supraoptic area . Positive_regulation NGFR NGF 1671048 151273 To determine if *regulated* [NGF receptor] gene expression at the transcriptional level , we examined PC12 cells . Positive_regulation NGFR NGF 1850821 155673 High-affinity binding *requires* coexpression of the trk proto-oncogene and the low-affinity [NGF receptor] . Positive_regulation NGFR NGF 1850821 155675 Reconstitution experiments by membrane fusion and transient transfection into heterologous cells indicate that high-affinity binding *requires* coexpression and binding to both the low-affinity [NGF receptor] and the tyrosine kinase trk gene product . Positive_regulation NGFR NGF 2560393 124617 *induction* of [NGF receptor] gene expression and cholinergic neuronal hypertrophy within the basal forebrain of the adult rat . Positive_regulation NGFR NGF 2560393 124618 In situ hybridization showed *induction* of [NGF-R] gene expression , documented by increases in the number of NGF-R mRNA positive cells within the medial septum , diagonal band , and nucleus basalis magnocellularis . Positive_regulation NGFR NGF 2847094 98886 The *induction* of [NGF-R] expression by was associated with an increase in the relative level of a 3.8 kb mRNA species encoding this protein . Positive_regulation NGFR NGF 2847094 98909 Whereas the *induction* of the [NGF-R] by and FGF were both fully inhibited by cholera toxin and cordycepin , the responses were differentially inhibited by the kinase inhibitor K-252a . Positive_regulation NGFR NGF 7891166 299625 The detection of relatively high amounts of NGF synthesis in the BF-S was supported in studies demonstrating rapid [NGF receptor] ( Trk ) *activation* in the basal forebrain by exogenous and in experiments showing that NGF mRNA was inducible in the BF-S by 1,25 dihydroxyvitamin D3 . Positive_regulation NGFR NGF 7891184 299627 Induction of L1 mRNA in PC12 cells by is modulated by cell-cell contact and does not *require* the high-affinity [NGF receptor] . Positive_regulation NGFR NGF 8293873 248161 These data therefore suggest that , in addition to promoting local sprouting , increased target derived *increases* the levels of p75 [NGF receptor] relative to trkA on terminal neurites , by differentially regulating receptor synthesis . Positive_regulation NGFR NGF 8955210 401367 It is , however , unknown whether other homologous neurotrophins also act outside the nervous system , and whether activation of basophils by *requires* interaction with trk tyrosine kinase receptors , the low affinity [NGF receptor] ( LNGFR ) , or both . Positive_regulation NGFR NGF 9795112 543201 The timing of mRNA expression after injury and the phenotype of identified trigeminal neurons suggests a complex signaling cascade in which at the injury site *regulates* [NGF receptor] expression at the levels of the cell body as well as increases in BDNF expression . Positive_regulation NGFR TGFB1 7536747 300289 In the case of purified Schwann cells , treatment with increases their proliferation , and it *promotes* a pre- or nonmyelinating Schwann cell phenotype characterized by increased NCAM expression , decreased [NGF receptor] expression , inhibition of the forskolin mediated induction of the myelin protein P0 , and induction of the Schwann cell transcription factor suppressed cAMP-inducible POU protein . Positive_regulation NID1 IL1B 18434122 1926380 or TNF-alpha alone *induced* increased secretion of type IV collagen , laminin-1 , and [nidogen-1/entactin] , all of which contributed to this upregulation . Positive_regulation NID1 TNF 18434122 1926379 IL-1beta or alone *induced* increased secretion of type IV collagen , laminin-1 , and [nidogen-1/entactin] , all of which contributed to this upregulation . Positive_regulation NIDDM1 CFI 3266138 103101 CH50 , C3 , C4 and significantly *increased* in both IDDM and [NIDDM] compared with non-diabetic healthy controls . Positive_regulation NIDDM2 CFI 3266138 103102 CH50 , C3 , C4 and significantly *increased* in both IDDM and [NIDDM] compared with non-diabetic healthy controls . Positive_regulation NIPA1 EPHB2 22955283 2693390 Mutation of either Ser-354 or Ser-359 abolished *dependent* [NIPA] phosphorylation . Positive_regulation NIPA2 EPHB2 22955283 2693391 Mutation of either Ser-354 or Ser-359 abolished *dependent* [NIPA] phosphorylation . Positive_regulation NKRF ARSA 22209714 2549750 *increased* the protein levels of the [transcription factor Nrf2] , which is a regulator of the phase-II enzymes . Positive_regulation NKRF EPHB2 21808062 2476886 Activation of H-Ras and *promoted* nuclear translocation of the [transcription factor Nrf2] for its binding to the specific sequence of HO-1 promoter . Positive_regulation NKX2-1 IL1B 19076932 2024218 and IL-10 *induced* [thyroid transcription factor-1] expression . Positive_regulation NKX2-1 TNF 19037882 2017361 Glucocorticoids , cAMP and TGF-beta ( transforming growth factor-beta ) have stimulatory effects on TTF-1 expression , whereas ( tumour necrosis factor-alpha ) and ceramide have inhibitory *effects* on [TTF-1] DNA binding activity in lung cells . Positive_regulation NLN EPHB2 16076765 1442259 [MEP] also *induced* activation of , JNK , and p38 signaling pathways and produced an increase of oxidative stress in A549 cells . Positive_regulation NLRP2 TNF 18056399 1833529 Notably , stimulation of HEK293T cells with or overexpression of the p65 subunit of NF-kappaB *resulted* in up-regulation of [NLRP2] and the formation of NF-kappaB-NLRP2 promoter complexes . Positive_regulation NLRP3 DAPK1 24220855 2897392 For example , by virtue of protein-protein interactions alone , *activates* pyruvate kinase isoform M2 , the microtubule affinity regulating kinases and inflammasome protein [NLRP3] , to promote glycolysis , influence microtubule dynamics , and enhance interleukin-1ß production , respectively . Positive_regulation NLRP3 IL1B 17403772 1760723 Using mice bearing selective gene deletions , we provide in vitro and in vivo data showing that MDP induced release *requires* Nod2 and [CIAS1/NALP3] as well as receptor interacting protein-2 (Rip2) , apoptosis associated speck-like protein containing a caspase activation and recruitment domain ( ASC ) , and caspase-1 . Positive_regulation NLRP3 IL1B 19950187 2217339 Although beta-hematin , a synthetic compound of the parasites heme polymer hemozoin , *induced* the release of in macrophages through [Nlrp3] , we did not obtain evidence for a role of IL-1beta in vivo . Positive_regulation NLRP3 IL1B 20193001 2216274 Having entered the cell , MSU further triggers [NALP3] inflammasome activation and *induces* the production of , likely inducing a full spectrum of inflammation . Positive_regulation NLRP3 IL1R2 22898816 2682852 Toll or ( TIR ) domain containing adaptor inducing interferon-ß ( TRIF ) -mediated caspase-11 protease production integrates Toll-like receptor 4 (TLR4) protein- and [Nlrp3] inflammasome *mediated* host defense against enteropathogens . Positive_regulation NLRP3 TLR7 20348425 2244859 Studies with purified V. cholerae hemolysin revealed that toxin stimulated [NLRP3] activation was *induced* by and nucleotide binding oligomerization domain 1/2 ligand mediated NF-kappaB activation . Positive_regulation NLRP3 TLR7 22569257 2596930 induced NF-?B activation *regulates* [NLRP3] expression in murine macrophages . Positive_regulation NLRP3 TLR7 22569257 2596950 Therefore , out results delineated the molecular mechanisms involved in *induced* transcriptional regulation of [NLRP3] . Positive_regulation NLRP3 TNF 15498798 1387341 FLS from RA and OA tissue expressed low baseline levels of [cryopyrin] transcripts that were *induced* by . Positive_regulation NM ANGPT1 17215522 1709686 Angiopoietins induce a rapid and transient Akt phosphorylation , and pretreatment of neutrophils with PI-3K inhibitors , wortmannin ( 100 nM ) and LY294002 ( 500 nM ) , reduced *mediated* [neutrophil migration] by 100 % and 78 % and Ang2 chemotactic activity by 100 % and 71 % , respectively . Positive_regulation NM ANGPT1 21881497 2478085 In contrast , can *promote* monocyte and [neutrophil migration] . Positive_regulation NM EDN2 18854982 2028644 Herein , we investigated whether *mediated* mechanical hypernociception ( decreased nociceptive threshold , evaluated by electronic pressure-meter ) and [neutrophil migration] ( myeloperoxidase activity ) are inter dependent in antigen challenge induced Th1-driven hind-paw inflammation . Positive_regulation NM IL1B 11114238 757774 Recombinant human interleukin-8 , but not human , *induces* bovine [neutrophil migration] in an in vitro co-culture system . Positive_regulation NM IL1B 17874178 1858297 [Neutrophil migration] *induced* by depends upon LTB4 released by macrophages and upon TNF-alpha and IL-1beta released by mast cells . Positive_regulation NM IL1B 17874178 1858298 In the present study , we investigate whether mast cells and macrophages are involved in the control of *induced* [neutrophil migration] , as well as the participation of chemotactic mediators . Positive_regulation NM IL1B 17874178 1858300 IL-1beta induced a dose dependent neutrophil migration to the peritoneal cavity of rats which depends on LTB ( 4 ) , PAF and cytokines , since the animal treatment with inhibitors of these mediators ( MK 886 , PCA 4248 and dexamethasone respectively ) inhibited *induced* [neutrophil migration] . Positive_regulation NM IL1B 17874178 1858301 The [neutrophil migration] *induced* by is dependent on mast cells and macrophages , since depletion of mast cells reduced the process whereas the increase of macrophage population enhanced the migration . Positive_regulation NM IL1B 17874178 1858302 Moreover , mast cells or macrophages stimulated with IL-1beta released a neutrophil chemotactic factor , which mimicked the [neutrophil migration] *induced* by . Positive_regulation NM IL1B 17874178 1858304 In conclusion , our results suggest that [neutrophil migration] *induced* by depends upon LTB ( 4 ) released by macrophages and upon IL-1beta and TNFalpha released by mast cells . Positive_regulation NM IL1B 18203872 1883831 Conversely , hypernociception and [neutrophil migration] *induced* by TNF-alpha , , and CINC-1/CXCL1 was inhibited by fucoidin , suggesting that neutrophils are involved in the production of direct acting hypernociceptive mediators . Positive_regulation NM IL1B 1916898 168247 Pre-treatment of the animals with dexamethasone ( 0.5 mg/kg , s.c. ) or depletion of the peritoneal resident cell population abolished the [neutrophil migration] *induced* by rIL-8 and by recombinant ( rIL-1 beta ) . Positive_regulation NM IL1B 20472598 2301087 Antigen- and IL-33 induced [neutrophil migration] in the joint was *dependent* on CXCL1 , CCL3 , tumour necrosis factor alpha (TNFalpha) and synthesis . Positive_regulation NM ITGA9 11239795 764165 The *mediates* [neutrophil migration] across several ligands that are enriched at sites of inflammation . Positive_regulation NM ITGAL 11950807 930341 In turn , [neutrophil migration] into the indomethacin inflamed small intestine is *mediated* by and CD11b/CD18 . Positive_regulation NM ITGB2 10713339 675944 [Neutrophil migration] across mammary arterial endothelial cells was almost completely *dependent* on , the beta-chain of the beta ( 2 ) integrins , and to a lesser extent on CD11b , one of the alpha-chains of the beta ( 2 ) integrins . Positive_regulation NM ITGB2 11950807 930343 In turn , [neutrophil migration] into the indomethacin inflamed small intestine is *mediated* by CD11a/CD18 and . Positive_regulation NM ITGB2 15172971 1288542 In the present study , we provide evidence , using a panel of novel monoclonal antibodies against human laminin alpha4 (LNalpha4) chain , that neutrophils contain and secrete LN-8 , and that this endogenous laminin contributes to chemoattractant induced , *dependent* [neutrophil migration] through albumin coated filters . Positive_regulation NM MAP2K6 9405284 480179 This demonstrates that , while neither nor ERK kinases are *involved* in the activation of respiratory burst or [neutrophil migration] , inhibition of PAF release suggests a potential role in the activation of cytosolic phospholipase A2 . Positive_regulation NM MIP 15518334 1328711 A synthetic , non-peptide CXCR2 antagonist blocks *induced* [neutrophil migration] in mice . Positive_regulation NM MIP 15518334 1328712 Our data show that SB 455821 blocks *induced* [neutrophil migration] in vitro and after injection in mice suggesting that selective CXCR2 antagonists may be useful drugs in diseases where neutrophil accumulation plays a major role and leads to exacerbation of acute or chronic inflammations . Positive_regulation NM MIP 16856209 1607198 We have recently shown that antigen induced [neutrophil migration] into the peritoneum of immunized mice is *mediated* by which interacts with CCR1 and induces the sequential release of TNF-alpha and leukotriene B ( 4 ) ( LTB ( 4 ) ) . Positive_regulation NM MIP 18439853 1908252 It was possible to conclude that calcium hydroxide induced [neutrophil migration] to the air-pouch cavity in mice is *mediated* by LTB ( 4 ) , TNF-alpha , KC , , and prostaglandins , but it was not dependent on macrophages or mast cells . Positive_regulation NM PECAM1 12417630 1013040 The results demonstrate a role for PECAM-1 homophilic interaction in neutrophil transmigration and increased expression of alpha ( 6 ) beta ( 1 ) on the cell surface of transmigrated neutrophils in vivo , a response that could contribute to the mechanism of *mediated* [neutrophil migration] through the PBM . Positive_regulation NM TLR7 17662043 1848654 *mediated* [neutrophil migration] was strongly suppressed by pretreatment of cells with U0126 ( MAPK/ERK kinase inhibitor ) but not with U0124 ( an inactive analogue of U0126 ) or SB203580 ( a p38 MAPK inhibitor ) , and was almost completely abolished by pretreatment of cells with U0126 and SB203580 in combination . Positive_regulation NM TNF 10358198 618962 Inhibition of IL-8 and production by acute EtOH intoxication may *inhibit* inflammatory focused [neutrophil migration] and activation and may be a mechanism explaining the increased risk of trauma- and burn related infections . Positive_regulation NM TNF 1681733 169046 69 % of T-cell movement and 80 % of [neutrophil migration] *induced* by the treated keratinocyte cell supernatants could be inhibited by anti-interleukin-8 (IL-8) serum . Positive_regulation NM TNF 18203872 1883829 Conversely , hypernociception and [neutrophil migration] *induced* by , IL-1beta , and CINC-1/CXCL1 was inhibited by fucoidin , suggesting that neutrophils are involved in the production of direct acting hypernociceptive mediators . Positive_regulation NM TNF 18472833 478844 MNCF has been shown to be active in rats treated with dexamethasone , a glucocorticoid that usually inhibits the [neutrophil migration] *induced* in this species by interleukin (IL)-1 , , IL-8 , C5a and leukotriene B ( 4 ) ( LTB ( 4 ) ) . Positive_regulation NM TNF 18594782 1931614 Activation of endothelial protein kinase C ( PKC ) by either phorbol myristate acetate ( PMA ) or bryostatin-1 ( a potent PKC delta and epsilon activator ) completely abolished [neutrophil migration] *mediated* by either endothelial stimulation or LTB4 . Positive_regulation NM TNF 18716928 1951043 Unlike the response to LPS , [neutrophil migration] in *response* to was not altered by the presence of lung epithelial cells , except at a low concentration of TNF-alpha upon alveolar directional exposure of the endothelium , i.e. , from the epithelial side of the bilayer . Positive_regulation NM TNF 20472598 2301084 Antigen- and IL-33 induced [neutrophil migration] in the joint was *dependent* on CXCL1 , CCL3 , and IL-1beta synthesis . Positive_regulation NM TNF 21968692 2507448 IL-33 may play a role in AS development via enhancing production by PBMCs and *inducing* [neutrophil migration] . Positive_regulation NM TNF 2201176 140439 These results suggest that the [neutrophil migration] *induced* by IL-1 alpha , IL-1 beta , and TNF beta is not due to a direct effect on neutrophils , but occurs via the release of a chemotactic factor ( s ) from resident macrophages . Positive_regulation NM TNF 7722453 301831 Fibrin regulates [neutrophil migration] in *response* to interleukin 8 , leukotriene B4 , , and formyl-methionyl-leucyl-phenylalanine . Positive_regulation NM TNF 8144974 252572 Thus , we examined *induced* [neutrophil migration] through polycarbonate filters and human pulmonary type II-like epithelial ( A549 ) cells cultured as monolayers on these filters . Positive_regulation NM TNF 8166294 254870 Therefore , we examined *induced* [neutrophil migration] through polycarbonate filters and human umbilical vein endothelial ( HUVE ) cells cultured as monolayers on these filters . Positive_regulation NM TNF 8166294 254871 Pretreatment of HUVE monolayers with actinomycin D inhibited both *induced* production of soluble chemotactic factors and transendothelial [neutrophil migration] by > 90 % . Positive_regulation NM TNF 8323453 223241 On the other hand , *induced* neither [neutrophil migration] nor enhancement of PAF induced neutrophil migration . Positive_regulation NM TNF 9306414 454329 and exogenous recombinant , IL-1 , IL-6 and CINC *induced* [neutrophil migration] into rat pleural cavity . Positive_regulation NM TNF 9409559 471477 Enhanced *induced* [neutrophil migration] through A549 monolayers in the basal-to-apical direction occurred regardless of whether the TNF-alpha was above or below the filter/monolayer complex . Positive_regulation NMS TNF 23009365 2843209 All [NMs] significantly *increased* IL-8 production , with no change in levels of and IL-6 . Positive_regulation NMU CTGF 22761259 2634504 *mediated* upregulation of [neuromedin U] expression in trabecular meshwork cells and its role in homeostasis of aqueous humor outflow . Positive_regulation NMU CTGF 22761259 2634506 Moreover , [NMU] , whose expression is induced in *response* to , partially mimics the effects of CTGF on actomyosin organization in TM cells , and decreases AH outflow facility , revealing a potentially important role for this neuropeptide in the homeostasis of AH drainage . Positive_regulation NNMT HNF1B 15486044 1359310 *Activation* of [nicotinamide N-methyltransferase] gene promoter by in human papillary thyroid cancer cells . Positive_regulation NNMT HNF1B 15486044 1359311 Furthermore , transient expression of in BHP 14-9 cells *increased* endogenous [NNMT] protein levels . Positive_regulation NNMT IFNG 20495288 2263638 Conversely , significantly *increased* [NNMT] activity and the nicotinamide cellular concentration , while leaving NNMT expression and the NAD ( + ) cellular concentration unchanged . Positive_regulation NNMT IL6 17922140 1882547 In Hep-G2 cells and SW480 colon cancer cells , [NNMT] expression *increased* on stimulation of the cells with . Positive_regulation NNMT IL6 20110558 2235657 In skeletal myoblasts , [NNMT] expression was significantly *induced* by , transforming growth factor beta , and tumor necrosis factor-alpha . Positive_regulation NNMT IL6 22661188 2610855 Interestingly , exercise induced activation of [NNMT] in the liver *involves* , while the rise in MNA concentration in plasma was partially IL-6 independent . Positive_regulation NNMT STAT3 17922140 1882548 [NNMT] promoter activity in Hep-G2 cells was *dependent* on the activation of . Positive_regulation NNMT TGFB1 20110558 2235654 In skeletal myoblasts , [NNMT] expression was significantly *induced* by IL-6 , , and tumor necrosis factor-alpha . Positive_regulation NNMT TGFB2 20110558 2235655 In skeletal myoblasts , [NNMT] expression was significantly *induced* by IL-6 , , and tumor necrosis factor-alpha . Positive_regulation NNMT TGFB3 20110558 2235656 In skeletal myoblasts , [NNMT] expression was significantly *induced* by IL-6 , , and tumor necrosis factor-alpha . Positive_regulation NOD1 IL1B 16021603 1441576 [NOD1] activation by low nanomolar concentrations of the specific muropeptide ligand M-TriDAP *induced* minimal human peripheral blood mononuclear cell TNF-alpha , or IL-10 secretion , but synergistically increased Toll-like receptor (TLR) induced responses . Positive_regulation NOD1 TNF 16418393 1514591 [Nod1] stimulation did not *induce* , interleukin 12 , and interferon gamma , suggesting that the primary role of Nod1 is to induce the recruitment of immune cells . Positive_regulation NOD2 IL1B 16288731 1490604 Human umbilical vascular endothelial cells ( HUVECs ) minimally expressed NOD2 gene , whereas stimulation of HUVEC with bacterial LPS , , or TNF-alpha *resulted* in significant up-regulation of [NOD2] . Positive_regulation NOD2 IL1B 17403772 1760726 Using mice bearing selective gene deletions , we provide in vitro and in vivo data showing that MDP induced release *requires* [Nod2] and CIAS1/NALP3 as well as receptor interacting protein-2 (Rip2) , apoptosis associated speck-like protein containing a caspase activation and recruitment domain ( ASC ) , and caspase-1 . Positive_regulation NOD2 IL1B 18773284 2028349 Combined TLR2 and [NOD2] stimulation *induced* a four-fold higher secretion of TNFalpha and a 13-fold higher secretion of in patients . Positive_regulation NOD2 TLR7 17559936 1842021 Furthermore , and NOD2 ligands as well as immunobiotic lactic acid bacteria ( LAB ) *enhanced* the expression of [NOD2] in gut associated lymphoid tissues (GALT) in adult and newborn swine . Positive_regulation NOD2 TLR7 19180502 2033152 After *up-regulation* of [NOD-2] by ligands , its ligand muramyl dipeptide ( MDP ) increased the expression of IL-6 and IL-8 via p38 and NF-kappaB . Positive_regulation NOD2 TNF 12194982 997820 Notably , stimulation of myeloblastic and epithelial cells with bacterial lipopolysaccharide or *resulted* in up-regulation of [Nod2] . Positive_regulation NOD2 TNF 12194982 997823 Upon *stimulation* with or lipopolysaccharide , both p50 and p65 subunits of NF-kappaB were bound to the [Nod2] promoter . Positive_regulation NOD2 TNF 12671897 1076276 and IFN-gamma *regulate* the expression of the [NOD2] ( CARD15 ) gene in human intestinal epithelial cells . Positive_regulation NOD2 TNF 12671897 1076281 *induced* an up-regulation of [NOD2] in epithelial cell lines ( HT-29 , SW620 , SW948 , HeLa S3 ) and in primary colonic epithelial cells . Positive_regulation NOD2 TNF 12835899 1107868 [NOD2] mRNA levels increased greater than two-fold in a monocyte cell line in *response* to lipopolysaccharide , lipoteichoic acid , interferon-g and . Positive_regulation NOD2 TNF 16034140 1436478 *Induction* of [Nod2] mRNA expression by LPS but not by in osteoblasts was dependent on TLR4 and MyD88 . Positive_regulation NOD2 TNF 16164210 1456242 Osteoblasts express [NOD2] , an intracellular sensor for MDP , in *response* to LPS , IL-1 and . Positive_regulation NOD2 TNF 16288731 1490603 Human umbilical vascular endothelial cells ( HUVECs ) minimally expressed NOD2 gene , whereas stimulation of HUVEC with bacterial LPS , IL-1beta , or *resulted* in significant up-regulation of [NOD2] . Positive_regulation NOD2 TNF 16465024 1522953 Osteoblasts express [nucleotide oligomerization domain (NOD)2] , an intracellular sensor for MDP , in *response* to LPS , IL-1 and . Positive_regulation NOD2 TNF 18773284 2028348 Combined TLR2 and [NOD2] stimulation *induced* a four-fold higher secretion of and a 13-fold higher secretion of IL-1 beta in patients . Positive_regulation NOD2 TNF 20470259 2262965 and IFN-gamma *increased* [NOD2] expression in HGFs . Positive_regulation NODAL EPHB2 24098142 2852198 However , even weakly activated *activates* Otx and [Nodal] transcription occasionally , probably because of the inherently stochastic nature of signal transduction processes and binding of transcription factors to target sequences . Positive_regulation NOG EPHB2 10617116 656438 Thus , activation of may not be essential for neuronal differentiation in F11 cells and alphao may *cause* changes in [NOG] by inhibiting CREB activation . Positive_regulation NOG ZIC2 21211521 2386306 Myf5 activation in newly forming somites is delayed in Zic2 mutant embryos until the time of Zic1 activation , and both and Myf5 *require* [noggin] for their activation . Positive_regulation NONO TNF 18439917 1920992 Furthermore , we found that TNFalpha oxidized DJ-1 , which may be essential for the NonO-P4Halpha1 interaction because treatment with gene specific siRNA to knockout DJ-1 eliminated the *induced* [NonO-P4Halpha1] interaction and its suppression . Positive_regulation NOS1 ARSA 18077625 1868182 Therefore , <5-ASA> prevents irradiation *induced* inflammatory processes as well as expression of tumor necrosis factor alpha , monocyte chemotactic protein-1 , inducible [nitric-oxide synthase] , and macrophage infiltration . Positive_regulation NOS1 BLVRA 25206501 2886916 We hypothesize that dependent *inducible* [nitric oxide synthase] regulation strongly contributes to the cognitive improvement observed following atorvastatin treatment . Positive_regulation NOS1 CAPN8 10835326 699138 *Role* of in hypoxic inhibition of [nitric oxide synthase] activity in pulmonary endothelial cells . Positive_regulation NOS1 CAPN8 11054482 745420 This allows a large increase in cytosolic Ca ( 2+ ) associated with activation of , calcineurin , and phospholipases with consequent proteolysis of calpain substrates ( including spectrin and eIF4G ) , *activation* of [NOS] and potentially of Bad , and accumulation of free arachidonic acid , which can induce depletion of Ca ( 2+ ) from the ER lumen . Positive_regulation NOS1 CAPN8 18624772 2179421 Activation of protease by oxidized and glycated LDL *increases* the degradation of endothelial [nitric oxide synthase] . Positive_regulation NOS1 EDN2 10770961 686088 Dysfunctional renal [nitric oxide synthase] as a determinant of salt-sensitive hypertension : mechanisms of renal artery endothelial dysfunction and *role* of for vascular hypertrophy and Glomerulosclerosis . Positive_regulation NOS1 EDN2 11223352 787878 *contributes* to [NOS] inhibition induced growth restriction acting through the ET ( A ) receptor . Positive_regulation NOS1 EDN2 9473143 476301 *enhances* lipopolysaccharide induced expression of inducible [nitric oxide synthase] in rat glial cells . Positive_regulation NOS1 EPHB2 12372406 996385 Porphyromonas gingivalis lipopolysaccharide interferes with salivary mucin synthesis through inducible [nitric oxide synthase] *activation* by and p38 kinase . Positive_regulation NOS1 EPHB2 19497418 2091845 LPS- and LTA induced [NOS/NO] productions were significantly *suppressed* by the JNK inhibitor , SP600125 , but not by the inhibitor , PD98059 , through a reduction in JNK protein phosphorylation . Positive_regulation NOS1 EPHB2 22205701 2549728 Inhibition of *reduced* both [nNOS] activation and NO secretion . Positive_regulation NOS1 FAS 14967838 1220246 signaling *induces* Akt activation and upregulation of endothelial [nitric oxide synthase] expression . Positive_regulation NOS1 FAS 14967838 1220258 Here , we report that engagement with Fas ligand *induced* activation of Akt and upregulation of endothelial [nitric oxide synthase] expression without induction of apoptosis . Positive_regulation NOS1 FAS 15317908 1286371 Death promoting effects have been ascribed to inhibition of nuclear factor-kappaB , increase of expression , p53 stabilization , cytokine and chemokine release , and *activation* of [nitric oxide synthase] , p38 , and c-Jun-N-terminal kinase . Positive_regulation NOS1 IL1B 10365824 621118 We have previously reported that the inflammatory cytokine *induced* the expression of the inducible [nitric oxide synthase] gene in primary cultured rat hepatocytes . Positive_regulation NOS1 IL1B 10406194 629398 *increased* levels of inducible [nitric oxide synthase] protein and inducible nitric oxide synthase mRNA , as well as nitric oxide production , in the cultured hepatocytes . Positive_regulation NOS1 IL1B 10406194 629401 FK506 markedly inhibited the nitric oxide formation , inducible [nitric oxide synthase] protein synthesis and inducible nitric oxide synthase mRNA expression *induced* by , but cyclosporin A had no effects . Positive_regulation NOS1 IL1B 10523329 653401 N-acetyl-L-cysteine enhances *induced* [nitric oxide synthase] expression . Positive_regulation NOS1 IL1B 10523329 653404 The effect of N-acetyl-L-cysteine on *induced* [nitric oxide synthase] expression was studied in rat vascular smooth muscle cells to determine if the reduction/oxidation state would modulate cytokine induced changes . Positive_regulation NOS1 IL1B 10593906 572864 Both p38alpha ( MAPK ) and JNK/SAPK pathways are important for *induction* of [nitric-oxide synthase] by in rat glomerular mesangial cells . Positive_regulation NOS1 IL1B 10702213 672495 Superoxide enhances *mediated* transcription of the hepatocyte-inducible [nitric oxide synthase] gene . Positive_regulation NOS1 IL1B 10775561 686635 N-Acetyl-L-cysteine potentiates *induction* of [nitric oxide synthase] : role of p44/42 mitogen activated protein kinases . Positive_regulation NOS1 IL1B 10871193 706785 However , normal *mediated* translocation of NF-kappaB and induction of inducible [nitric oxide synthase] expression and nitric oxide production was severely impaired in the INS-1res cell lines , suggesting a mechanism for the IL-1beta resistance . Positive_regulation NOS1 IL1B 10882405 709472 4. Moreover , CGP-43182 completely blocked *induced* gene expression of the inducible [nitric oxide synthase] , leading to an inhibition of cytokine stimulated nitric oxide formation . Positive_regulation NOS1 IL1B 10967106 751777 Inducible [nitric oxide synthase] mRNA accumulation and nitrite production , which *required* the simultaneous presence of and IFN-gamma , were also suppressed by approximately 70 % , and these cells were more resistant to cytokine induced apoptosis as compared with parental cells . Positive_regulation NOS1 IL1B 10967106 751784 These results demonstrate that is *involved* in inducible [nitric oxide synthase] gene expression and induction of apoptosis in mouse beta cells but does not contribute to impaired glucose stimulated insulin secretion . Positive_regulation NOS1 IL1B 11024034 767723 The resistance to IL-1 beta plus IFN-gamma in STAT-1 alpha expressing cells is due in part to interference with *mediated* stimulation of inducible [nitric-oxide synthase] expression and nitric oxide production . Positive_regulation NOS1 IL1B 11222532 787679 The purpose of these studies was to investigate the *role* of interferon-gamma (IFN-gamma) , tumor necrosis factor-alpha (TNF-alpha) , , and transforming growth factor-beta ( TGF-beta ) in the regulation of inducible [nitric oxide synthase] ( NOS2 ) activity in rabbit corneal cells . Positive_regulation NOS1 IL1B 11287034 799930 Aspirin dose dependently inhibits the *stimulated* increase in inducible [nitric oxide synthase] , nitric oxide , and prostaglandin E ( 2 ) production in rat ovarian dispersates cultured in vitro . Positive_regulation NOS1 IL1B 11457450 838165 15-deoxy-Delta12,14-prostaglandin J2 ( 15d-PGJ2 ) , in contrast to troglitazone , was highly potent to counteract *induced* cyclooxygenase-2 and inductible [nitric oxide synthase] expression , NO production and the decrease in proteoglycan synthesis . Positive_regulation NOS1 IL1B 11506125 847933 Halothane but not isoflurane attenuates *induced* [nitric oxide synthase] in vascular smooth muscle . Positive_regulation NOS1 IL1B 11530235 853781 *induced* both [nitric oxide synthase 2 (NOS-2)] and cyclooxygenase 2 (COX-2) gene expression in dorsal root ganglion explant culture with increased NOS-2 and COX-2 activities , and corresponding increases in the production of nitric oxide and prostaglandin E ( 2 ) . Positive_regulation NOS1 IL1B 11956484 931193 The induction of inducible [nitric oxide synthase] in the urothelium appears to *depend* on the synergistic effect of and TNF-alpha . Positive_regulation NOS1 IL1B 12209512 983970 Epigallocatechin-3-gallate inhibits *induced* expression of [nitric oxide synthase] and production of nitric oxide in human chondrocytes : suppression of nuclear factor kappaB activation by degradation of the inhibitor of nuclear factor kappaB . Positive_regulation NOS1 IL1B 12365794 995288 in intra-islet macrophages may *induce* Fas and inducible [nitric oxide synthase] expression in an autocrine and paracrine manner and mediate beta cell destruction or even death of some macrophages and T cells . Positive_regulation NOS1 IL1B 12374621 996599 Green tea polyphenol epigallocatechin-3-gallate inhibits the *induced* activity and expression of cyclooxygenase-2 and [nitric oxide synthase-2] in human chondrocytes . Positive_regulation NOS1 IL1B 12390534 1000540 In contrast , chlomethiazole and SB203580 potently inhibited the *induced* expression of c-fos and inducible [nitric oxide synthase] , as monitored by northern blot and quantitative RT-PCR , respectively . Positive_regulation NOS1 IL1B 12390534 1000543 Because *induced* expression of c-fos and inducible [nitric oxide synthase] is believed to directly contribute to the pathology of cerebral ischaemic injury , the results suggest a direct mechanism for the neuroprotective effects of chlomethiazole and SB203580 , and further establish the anti-inflammatory properties of chlomethiazole . Positive_regulation NOS1 IL1B 12475221 1023537 In rat pancreatic islets and insulin producing cell lines , *induces* expression of inducible [nitric oxide synthase] and NO production leading to impairment of glucose stimulated insulin release and decreased cell survival . Positive_regulation NOS1 IL1B 1378360 190620 Balloon injury and *induce* [nitric oxide synthase] activity in rat carotid arteries . Positive_regulation NOS1 IL1B 1380466 195897 Furthermore , markedly *increased* the mRNA levels of the inducible macrophage form of [nitric oxide synthase] in HIT cells . Positive_regulation NOS1 IL1B 15450943 1300772 Inhibitory effects of epicatechin on induced *inducible* [nitric oxide synthase] expression in RINm5F cells and rat pancreatic islets by down-regulation of NF-kappaB activation . Positive_regulation NOS1 IL1B 15591777 1346247 Heme oxygenase-1 attenuates *induced* [nitric oxide synthase] expression in vascular smooth muscle cells . Positive_regulation NOS1 IL1B 15683716 1370645 Catalase potentiates *induced* expression of [nitric oxide synthase] in rat vascular smooth muscle cells . Positive_regulation NOS1 IL1B 15963682 1423158 Inhibitory effect of Buthus martensi Karsch extracts on *induced* expression of [nitric oxide (NO) synthase] and production of NO in human chondrocytes and LPS induced NO and prostaglandin E2 production in mouse peritoneal macrophages . Positive_regulation NOS1 IL1B 16782700 1590855 *increased* endothelial cell endothelial [nitric oxide (NO) synthase] ( eNOS ) expression but did not enhance eNOS activity as evidenced by release of NO ( x ) into conditioned medium in response to acetylcholine or shear stress . Positive_regulation NOS1 IL1B 17014957 1641451 Also , gamma-MSH ( 1 microg/microl ) eliminated the increase in [NOS] activity *induced* by . Positive_regulation NOS1 IL1B 17510469 1761924 induced expression and *activation* of inducible [nitric oxide synthase] and cyclooxygenase-2 were inhibited by apoE in vascular smooth muscle cells ( VSMCs ) . Positive_regulation NOS1 IL1B 17543124 1762547 Malarial pigment haemozoin , IFN-gamma , TNF-alpha , and LPS do not *stimulate* expression of inducible [nitric oxide synthase] and production of nitric oxide in immuno purified human monocytes . Positive_regulation NOS1 IL1B 19595066 2105454 [ Glutamine inhibits *induced* nitric oxide production and inducible [nitric oxide synthase] expression : experiment with cultured rat hepatocytes ] . Positive_regulation NOS1 IL1B 19763723 2247722 In vitro , muscone reversed *induced* upregulation of IL-1beta , tumor necrosis factor alpha , cyclooxygenase 2 , inducible [nitric oxide synthase] , matrix metalloproteinase 13 , aggrecanase 2 , and nitric oxide and downregulation of Col2alpha1 and aggrecan . Positive_regulation NOS1 IL1B 20141611 2178973 THS-78-5 was also able to attenuate induced *inducible* [nitric oxide synthase] expression and subsequent NO release . Positive_regulation NOS1 IL1B 20979884 2338692 Compared with uninfected control and Ad-eGFP infected group , Ad-mIL-10 infected group had decreased levels of NO and [NOS] *induced* by [ NO level ( nmol/10 ( 6 ) cells ) : 52.9 +/- 3.2 vs. 227.3 +/- 26.4 , 235.1 +/- 28.6 , both P < 0.05 ; NOS level ( U/10(6) cells ) : 9.3 +/- 1.2 vs. 29.8 +/- 2.5 , 30.5 +/- 2.8 , both P < 0.05 ] . Positive_regulation NOS1 IL1B 7487987 322995 Nicotinamide inhibits IRF-1 mRNA induction and prevents *induced* [nitric oxide synthase] expression in pancreatic beta cells . Positive_regulation NOS1 IL1B 7488131 332112 *induced* expression of [nitric oxide synthase] in rat renal mesangial cells is suppressed by cyclosporin A . Positive_regulation NOS1 IL1B 7504472 237417 Growth factor regulation of *induced* [nitric oxide synthase] and GTP : cyclohydrolase expression in cultured smooth muscle cells . Positive_regulation NOS1 IL1B 7505613 237678 *induces* the coexpression of both [nitric oxide synthase] and cyclooxygenase by islets of Langerhans : activation of cyclooxygenase by nitric oxide . Positive_regulation NOS1 IL1B 7506668 240008 Cyclosporin derivatives inhibit *induction* of [nitric oxide synthase] in renal mesangial cells . Positive_regulation NOS1 IL1B 7506700 244441 These findings suggest that interferon gamma directly *induces* the expression of the inducible [nitric oxide synthase] gene , whereas tumor necrosis factor-alpha and induce it , at least in part , via the induction of intermediary protein ( s ) , and that transforming growth factor-beta 1 inhibits cytokine induced nitric oxide production by blocking the posttranscriptional synthesis of inducible nitric oxide synthase . Positive_regulation NOS1 IL1B 7515501 257211 Stimulation with alone *leads* to an approximately 40-fold increase in [NOS] activity and nitrite synthesis , whereas the elevation of cAMP with forskolin , cholera toxin , salbutamol , or dibutyryl-cAMP for 24 h resulted in a 2- to 12-fold increase in NOS activity . Positive_regulation NOS1 IL1B 7515501 257212 increased NOS mRNA levels in a dose- and time dependent fashion with a peak of NOS mRNA at 24 h. Dibutyryl-cAMP also *increased* [NOS] mRNA levels in mesangial cells in a dose- and time dependent manner . Positive_regulation NOS1 IL1B 7517798 261745 *Induction* of [nitric oxide synthase] gene by in cultured rat cardiocytes . Positive_regulation NOS1 IL1B 7519215 265519 In addition , [NOS] activity was not *induced* in PMNs by LPS , , or IFN-gamma . Positive_regulation NOS1 IL1B 7521071 269273 Cyclic nucleotide regulation of *induced* [nitric oxide synthase] expression in vascular smooth muscle cells . Positive_regulation NOS1 IL1B 7523451 272202 Since the cytokine *induces* [nitric oxide synthase (NOS)] activity as well as effects morphogenic/cytotoxic changes and increased prostaglandin ( PGE2 ) levels in cultured whole ovarian dispersates , we set out to determine whether these actions are interrelated . Positive_regulation NOS1 IL1B 7526844 280504 Possible role of protein kinase C-epsilon isoenzyme in inhibition of *induction* of [nitric oxide synthase] in rat renal mesangial cells . Positive_regulation NOS1 IL1B 7527554 280833 The inflammatory cytokine *induces* both cyclooxygenase (COX) and [nitric oxide synthase (NOS)] with increases in the release of prostaglandin ( PG ) and nitric oxide ( NO ) by mesangial cells . Positive_regulation NOS1 IL1B 7533726 287712 These observations suggest that pyrrolidine dithiocarbamate prevents the *mediated* expression of the inducible [nitric oxide synthase] without affecting the activity of the constitutive enzyme in the rat aorta . Positive_regulation NOS1 IL1B 7533844 287717 The NOS activity induced by LPS in C6 cells was maximal at 4 to 8 hr and then rapidly decreased , while [NOS] activity *induced* by slowly decreased after 4 hr . Positive_regulation NOS1 IL1B 7534188 287735 1. These studies examine the effect of retinoids on *induced* [nitric oxide synthase (NOS)] activity in cultured rat aortic vascular smooth muscle ( VSM ) cells and isolated rat aortic rings . Positive_regulation NOS1 IL1B 7538755 306884 Ethanol potentiates stimulated *inducible* [nitric oxide synthase] expression in cultured vascular smooth muscle cells . Positive_regulation NOS1 IL1B 7539260 306998 We presently investigated the effects of pyrrolidine dithiocarbamate ( PDTC ) , a potent inhibitor of nuclear factor kappa B (NF-kappa B) , on the *induction* of [nitric oxide synthase] ( iNOS ) and manganese superoxide dismutase ( MnSOD ) mRNAs by in insulin producing RIN cells . Positive_regulation NOS1 IL1B 7588208 329806 *induced* [nitric oxide synthase] expression by rat pancreatic beta-cells : evidence for the involvement of nuclear factor kappa B in the signaling mechanism . Positive_regulation NOS1 IL1B 7679081 211180 These data suggest that *induced* [NOS] mRNA expression may be mediated by transcription of immediate early response genes , and that c-fos may be one of these genes . Positive_regulation NOS1 IL1B 7686532 222267 These data demonstrate for the first time that *induces* gene expression of inducible [nitric oxide synthase] and its de novo protein synthesis in rat vascular smooth muscle cells , thereby leading to generation of nitric oxide via Ca2+/calmodulin independent and protein kinase C-independent mechanisms . Positive_regulation NOS1 IL1B 7688219 225317 Endothelial cell [nitric oxide synthase] ( the constitutive enzyme ) was stimulated with bradykinin , and vascular smooth muscle cell nitric oxide synthase ( the inducible enzyme ) was *induced* with . Positive_regulation NOS1 IL1B 7689226 225722 resulting from cleavage of pIL-1 beta by SPE B *induced* [nitric oxide synthase] activity in vascular smooth muscle cells and killed of the human melanoma A375 line . Positive_regulation NOS1 IL1B 7689587 225786 *Induction* of [nitric oxide synthase] activity in human astrocytes by and interferon-gamma . Positive_regulation NOS1 IL1B 7965120 279645 This study further examines these questions by investigating the effects of Hb on the *induction* of [NOS] by . Positive_regulation NOS1 IL1B 8224196 234758 Damage also resulted following *induction* of [nitric oxide synthase] by the cytokine in both islets and HIT-T15 cells and was prevented by replacing the substrate , arginine , with nitromonomethyl arginine . Positive_regulation NOS1 IL1B 8224196 234761 Thus intracellular levels of nitric oxide generated by *induced* [nitric oxide synthase] were sufficient to cause DNA damage in islet cells and HIT-T15 cells . Positive_regulation NOS1 IL1B 8440413 213319 The purpose of this investigation was to determine if brief exposures of islets to IL-1 beta are sufficient to induce the formation of nitric oxide and to examine the signaling process associated with *induced* expression of [nitric oxide synthase] . Positive_regulation NOS1 IL1B 8630528 361260 Addition of 3-isobutyl-1-methyl xanthine resulted in a threefold reduction in the mRNA level of *induced* inducible [nitric oxide synthase] . Positive_regulation NOS1 IL1B 8662662 365420 Another antioxidant , rotenone , which inhibits reactive oxygen intermediate production by inhibiting the mitochondrial electron transport system , did not inhibit IL-1beta induced iNOS and Cox-2 mRNA expression but inhibited iNOS and Cox-2 protein expression , suggesting a post-transcriptional target for the inhibition of [NOS] and Cox-2 expression *induced* by . Positive_regulation NOS1 IL1B 8662809 367292 Suppression of *induced* [nitric-oxide synthase] promoter/enhancer activity by transforming growth factor-beta1 in vascular smooth muscle cells . Positive_regulation NOS1 IL1B 8666334 365568 Furthermore , markedly *increased* [NOS] activity , and this increase in activity was accompanied by the expression of inducible NOS (iNOS) messenger RNA ( mRNA ) . Positive_regulation NOS1 IL1B 8700134 375431 *Induction* of hepatic [nitric oxide synthase (NOS)] by tumor necrosis factor-alpha (TNF alpha) , , interferon-gamma (IFN gamma) , interleukin-6 (IL-6) , and lipopolysaccharide was assessed as activity and immunoreactive protein . Positive_regulation NOS1 IL1B 8737749 376969 Here we show that in cultured bovine chondrocytes and explants of human osteoarthritic cartilage both [nitric oxide synthase] and cyclooxygenase activities were *induced* by the inflammatory mediators , lipopolysaccharide , and or tumor necrosis factor-alpha . Positive_regulation NOS1 IL1B 8779862 379938 The results indicate that LPS induction of [NOS] activity in brain cells is *mediated* in part by both and TNF-alpha . Positive_regulation NOS1 IL1B 8943052 399486 Among the tetracycline group of compounds , doxycycline > minocycline blocked and reversed both spontaneous and *induced* [OA-NOS] activity in ex vivo conditions . Positive_regulation NOS1 IL1B 8977400 408784 Induction of guanosine triphosphate-cyclohydrolase by follicle stimulating hormone enhances *stimulated* [nitric oxide synthase] activity in granulosa cells . Positive_regulation NOS1 IL1B 8977400 408787 Treatment with the GTPCH inhibitor 2,4-diamino-6-hydroxypyrimidine prevented *induced* [NOS] activity in untreated or FSH stimulated cells , and this inhibition was completely reversed by sepiapterin , a substrate for BH4 biosynthesis , via an alternative pterin salvage pathway present in many cell types . Positive_regulation NOS1 IL1B 9153192 431084 In this study , we describe the opposing effects of these inhibitors on *stimulated* induction of [nitric-oxide synthase-2 (NOS-2)] in rat pulmonary artery smooth muscle cells ( RPASMC ) and rat hepatocytes . Positive_regulation NOS1 IL1B 9237621 445650 *Induction* of inducible [nitric oxide synthase] by tumor necrosis factor-alpha , interferon-gamma and inhibited cell proliferation and led to a G1 arrest . Positive_regulation NOS1 IL1B 9339386 458454 Transforming growth factor-beta 2 inhibits *induced* expression of inducible [nitric oxide synthase] in rat renal mesangial cells . Positive_regulation NOS1 IL1B 9369275 464002 Exogenous angiotensin II inhibited *stimulated* inducible [nitric oxide synthase] protein expression in both deendothelialized vessels and those with endothelium , although with reduced ability on the aortic segments with endothelium by a nitric oxide independent mechanism . Positive_regulation NOS1 IL1B 9369275 464005 In the aortic rings with endothelium , either inhibition of the AT-1 receptor with losartan or blocking of angiotensin II generation with fosinopril enhanced stimulated *inducible* [nitric oxide synthase] protein expression . Positive_regulation NOS1 IL1B 9395303 468381 Insulin-like growth factor I reverses inhibition of insulin secretion , *induction* of [nitric oxide synthase] and cytokine mediated apoptosis in rat islets of Langerhans . Positive_regulation NOS1 IL1B 9453318 484218 *stimulated* [ 3H ] citrulline forming activity of the [nitric oxide synthase (NOS)] was also significantly lower in high-glucose exposed cells , and this was reflected in diminished cellular levels of NOS protein . Positive_regulation NOS1 IL1B 9453318 484219 Increasing intracellular calcium by A23187 , an ionophore or thapsigargin , an inhibitor of endoplasmic reticulum Ca2+-ATPase , significantly decreased *induced* NO release and [NOS] expression . Positive_regulation NOS1 IL1B 9453318 484220 These results indicate that glucose induced inhibition of *stimulated* NO release and [NOS] expression may be mediated by PKC activation and increased intracellular calcium . Positive_regulation NOS1 IL1B 9652398 515855 However , in these cells , *induction* of inducible [nitric oxide synthase] , granulocyte-macrophage colony stimulating factor and cyclooxygenase-2 mRNA showed 70-90 % repression by dexamethsone . Positive_regulation NOS1 MAP2K6 15195252 1260135 When [NO synthase (NOS)] activity is *inhibited* by the specific inhibitor of NOS or , cells are prevented from death . Positive_regulation NOS1 MAP2K6 23764028 2828356 In the mosquito , ingested TGF-ß1 *induces* A. stephensi [NOS] ( AsNOS ) , which limits parasite development and which in turn is suppressed by activation of the mosquito homolog of the mitogen activated protein kinases and ERK . Positive_regulation NOS1 PGC 21435455 2406402 In addition to inactivation of forkhead transcription factor signaling through enhanced Akt/protein kinase B expression , in glycolytic muscles , overexpression *led* to enhanced expression of inducible [nitric oxide synthase] and endothelial nitric oxide synthase , production of nitric oxide , and expression of antioxidant enzyme including superoxide dismutases ( SOD1 , SOD2 , and SOD3 ) and catalase , and reduced oxidative stress . Positive_regulation NOS1 PLAT 17717150 1801515 In conclusion , our results demonstrate that after MCAO the interaction between and LRP *results* in NF-kappaB activation in astrocytes and induction of inducible [nitric-oxide synthase] expression in the ischemic tissue , suggesting a cytokine-like plasminogen independent role for tPA during cerebral ischemia . Positive_regulation NOS1 PLAU 21540184 2444673 ( uPA ) *induces* pulmonary microvascular endothelial permeability through low density lipoprotein receptor related protein ( LRP ) -dependent activation of endothelial [nitric-oxide synthase] . Positive_regulation NOS1 S100B 10627310 658980 The astrocyte derived *stimulates* production of inducible [nitric oxide synthase] and nitric oxide ( NO ) in astrocytes [ Hu et al. , 1996 , J. Biol. Chem. 271 : 2543 ] , but its effect on microglia is not known . Positive_regulation NOS1 S100B 12045670 950149 An astrocytic protein *enhances* the expression of inducible [nitric oxide synthase] in cultured astrocytes at micromolar concentrations , leading to nitric oxide mediated death of cocultured neurons . Positive_regulation NOS1 S100B 19923851 2197953 We suggest that overproduction of NO may account for neuronal death at the spinal cord of T. cruzi infected IL-12p40KO mice and that IFN-gamma and may *contribute* to [NOS] activation in the absence of IL-12 . Positive_regulation NOS1 S100B 8576219 350269 *stimulates* inducible [nitric oxide synthase] activity and mRNA levels in rat cortical astrocytes . Positive_regulation NOS1 SPHK1 16269668 1502334 Endothelial [nitric oxide synthase] *activation* by tumor necrosis factor alpha through neutral sphingomyelinase 2 , , and sphingosine 1 phosphate receptors : a novel pathway relevant to the pathophysiology of endothelium . Positive_regulation NOS1 SPHK1 16857953 1600463 *dependent* activation of endothelial [nitric oxide synthase] by angiotensin II . Positive_regulation NOS1 TLR7 10426995 632958 Several lipoproteins stimulated *dependent* transcription of inducible [nitric oxide synthase] and the production of nitric oxide , a powerful microbicidal pathway . Positive_regulation NOS1 TLR7 15994412 1446993 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for tumor necrosis factor ( TNF-alpha ) , interleukin 6 , [nitric oxide synthase-II] ( iNOS ) , and NADPH oxidase 2 (Nox2) . Positive_regulation NOS1 TNF 10084320 599194 A strong effect on inducible [nitric oxide synthase] gene expression could be *detected* when the cells were coincubated with the proinflammatory cytokines interferon-gamma and with inducible nitric oxide synthase cDNA concentrations averaging 11.7 +/- 0.6 amol per microg total RNA at 24 h , and 25.0 +/- 1.4 amol per microg total RNA at 48 h , respectively . Positive_regulation NOS1 TNF 10356322 618387 We investigated the molecular mechanism for the synergistic *induction* of inducible [nitric oxide synthase] transcription by and IFN-gamma . Positive_regulation NOS1 TNF 10545521 564620 This TNF-alpha production was associated with elevated levels of tetrahydrobiopterin ( BH ( 4 ) ) , a *stimulated* cofactor and enhancer of eNOS derived NO biosynthesis and [NOS] activity in mesenteric vasculature . Positive_regulation NOS1 TNF 10574230 568872 Nimodipine inhibited the Ca2+ independent [NOS] activity *induced* by lipopolysaccharide (LPS) + in mouse astroglial cells with an IC50 value of 0.036+/-0.003 mM and Ca2+ dependent NOS activity in mouse neurons with an IC50 value of 0.047+/-0.003 mM , but did not affect Ca2+ dependent NOS activity in BCECs . Positive_regulation NOS1 TNF 10713108 675820 Beta-amyloid stimulation of inducible [nitric-oxide synthase] in astrocytes is interleukin-1beta- and *dependent* , and involves a TNFalpha receptor associated factor- and NFkappaB inducing kinase dependent signaling mechanism . Positive_regulation NOS1 TNF 10929773 719749 Ultraviolet B radiation downregulates inducible [nitric oxide synthase] expression *induced* by interferon-gamma or in murine keratinocyte Pam 212 cells . Positive_regulation NOS1 TNF 11003590 734692 The characterization of the mechanisms responsible for the TNF-alpha effect on UCP-2 expression demonstrates an involvement of the induced *inducible* ( i ) [nitric oxide synthase (NOS)] expression . Positive_regulation NOS1 TNF 11031095 740156 and ( ii ) TNF-alpha initiated apoptosis may be mediated in part by NO as produced by a [NOS] expressed in *response* to . Positive_regulation NOS1 TNF 11085984 786351 *Activation* of the endothelial [nitric-oxide synthase] by . Positive_regulation NOS1 TNF 11160388 781723 beta-Amyloid stimulation of microglia and monocytes results in *dependent* expression of inducible [nitric oxide synthase] and neuronal apoptosis . Positive_regulation NOS1 TNF 11224628 787967 In contrast , [nitric oxide synthase] expression is *induced* by IL-1 , , and gamma interferon , a T-helper 1 cytokine profile . Positive_regulation NOS1 TNF 11399519 824228 Interferon (IFN)-gamma and Herpes simplex synergistically *induce* [nitric oxide synthase] 2 in macrophages through cooperative action of nuclear factor-kappa B and IFN regulatory factor-1 . Positive_regulation NOS1 TNF 11517169 851235 This action of GH may be sufficient to suppress the synergistic *induction* of inducible [nitric oxide synthase] by interferon-gamma and , thereby preventing the cytotoxicity to beta-cells . Positive_regulation NOS1 TNF 11943165 928668 Recombinant glucocorticoid induced receptor ( rGITR ) *induces* [NOS] in murine macrophage . Positive_regulation NOS1 TNF 11956484 931192 The induction of inducible [nitric oxide synthase] in the urothelium appears to *depend* on the synergistic effect of IL-1beta and . Positive_regulation NOS1 TNF 12858016 1110789 *Induction* of [nitric oxide synthase (NOS)] by soluble glucocorticoid induced receptor ( sGITR ) is modulated by IFN-gamma in murine macrophage . Positive_regulation NOS1 TNF 12884305 1116566 *mediates* the induction of [nitric oxide synthase] in macrophages but not in neutrophils in experimental cutaneous leishmaniasis . Positive_regulation NOS1 TNF 16328964 1503643 Both and inosine *increased* nitrite accumulation and [nitric oxide synthase] activity . Positive_regulation NOS1 TNF 16827641 1586615 The *role* of in mediating pathophysiological activity of inducible [nitric oxide synthase] during transplant vasculopathy remains contentious . Positive_regulation NOS1 TNF 16873093 1593281 On the other hand , BMK strongly inhibited interleukin-1beta (IL-1beta)- and *induced* [Nitricoxide (NO) synthase] expression with little effect on constitutive NO synthase expression . Positive_regulation NOS1 TNF 16876161 1600870 In addition , *stimulates* [NOS] catalytic activity . Positive_regulation NOS1 TNF 16940413 1639229 It suppressed the transcription of NF-kappaB downstream gene products including cyclooxygenase-2 and inducible [nitric-oxide synthase] *induced* by or lipopolysaccharide in macrophages and hepatocarcinoma cells . Positive_regulation NOS1 TNF 17851925 1910970 *Induction* of inducible [nitric oxide synthase] and apoptosis by LPS and in nasal microvascular endothelial cells . Positive_regulation NOS1 TNF 18275839 1937994 In Caco-2 cells , Hex ( 2.5-20 microM ) inhibited *induced* NF-kappaB activation ( IkappaB phosphorylation and degradation , p50 and RelA nuclear translocation , and NF-kappaB-DNA binding ) , inducible [nitric oxide synthase] expression , and cell oxidant increase . Positive_regulation NOS1 TNF 18295395 1896681 Our results showed that CS inhibited *induced* NF-kappaB activation and subsequent vascular cell adhesion molecule 1 and inducible [nitric oxide synthase] expressions by blocking Akt signals in JB6 cells . Positive_regulation NOS1 TNF 18339892 1912471 [NOS] was markedly *inhibited* by blocking antibodies to IFN-gamma and , suggesting the key role of these lymphocyte cytokines in mediating NOS . Positive_regulation NOS1 TNF 20135642 2235873 Integrin linked kinase is involved in induced *inducible* [nitric-oxide synthase] expression in myoblasts . Positive_regulation NOS1 TNF 20489729 2327428 *induced* activation of p38 MAPK and the production of inducible [nitric oxide synthase] were suppressed in ASK1-deficient Müller glial cells . Positive_regulation NOS1 TNF 20884819 2357069 Positive immunolabelings for interleukin-6 , *inducible* [nitric oxide synthase] , and dimeric copper- and zinc containing superoxide dismutase were observed mainly in the inflammatory cells in the lesions ; Positive_regulation NOS1 TNF 21637955 2531995 Aldose reductase regulates induced *inducible* [nitric oxide synthase] expression in human mesangial cells . Positive_regulation NOS1 TNF 22847916 2682368 and IFNG *stimulated* [NOS] activity ( P < 0.05 ) and 1400W , a specific inhibitor of iNOS , reduced NO production stimulated by TNF and IFNG in LECs ( P < 0.05 ) . Positive_regulation NOS1 TNF 23527096 2761979 In addition , NaHS treatment prevented the increase of nitric oxide , Intercellular Adhesion Molecule 1 ( ICAM-1 ) and interleukin (IL)-6 production and inducible [nitric oxide synthase] activation *induced* by . Positive_regulation NOS1 TNF 24905701 2952086 Furthermore , HMGB1 and IL-1ß and/or a ( but not HMGI/Y ) also significantly *induced* inducible [nitric oxide synthase] , NO , and interleukin (IL)-8 production in human cartilage and chondrocytes . Positive_regulation NOS1 TNF 7475350 331522 [Nitric oxide synthase (NOS)] activity was *enhanced* in human umbilical vein endothelial cells ( HUVECs ) by the combined stimulation with IFN-gamma plus IL-1beta , and LPS which was accompanied by cell death . Positive_regulation NOS1 TNF 7504484 237420 Nitric oxide and [nitric oxide synthase] mRNA *induction* in mouse islet cells by interferon-gamma plus . Positive_regulation NOS1 TNF 7506700 244439 These findings suggest that interferon gamma directly *induces* the expression of the inducible [nitric oxide synthase] gene , whereas and interleukin-1 beta induce it , at least in part , via the induction of intermediary protein ( s ) , and that transforming growth factor-beta 1 inhibits cytokine induced nitric oxide production by blocking the posttranscriptional synthesis of inducible nitric oxide synthase . Positive_regulation NOS1 TNF 7509010 240171 Dexamethasone inhibits [nitric oxide synthase] mRNA *induction* by interleukin-1 alpha and in vascular smooth muscle cells . Positive_regulation NOS1 TNF 7513301 253696 In this study , we determine whether produced by activated bone marrow derived macrophages ( BMM ) is *involved* in the induction of the inducible NO synthase gene ( [mac-NOS] ) for NO-dependent amebicidal activity . Positive_regulation NOS1 TNF 7525497 276920 [NOS] activity was *increased* by and IFN-gamma , and significantly reduced by tumor-cell conditioned medium . Positive_regulation NOS1 TNF 7529496 291452 The inflammatory mediators interleukin-1 beta (IL-1 beta) , and the bacterial cell wall fragment endotoxin , *induced* both [nitric oxide synthase] activity and stromelysin and collagenase activity in whole cell preparations and in conditioned media from explants of bovine and human cartilage . Positive_regulation NOS1 TNF 7539338 307015 Using previously published data , we developed a pharmacokinetic-pharmacodynamic model that relates the production of TNF in response to administration of FAA , the enhancement of [NOS] activity in *response* to , and the elevation of plasma nitrate in response to NO production . Positive_regulation NOS1 TNF 7543491 314294 IFN-gamma and , potent inhibitors of hematopoiesis , *induce* [nitric oxide synthase (NOS)] in various cell types . Positive_regulation NOS1 TNF 7573346 324957 Thus , interleukin-1 alpha and inducible [nitric oxide synthase] were *induced* mostly in the cells accumulated around the beads and also in some bronchiolar epithelial cells during the early phase ( 1 to 3 days ) , whereas was induced in the cells around the beads at the later resolution phase ( 3 to 7 days ) . Positive_regulation NOS1 TNF 7682342 214443 In combination , and IFN-gamma markedly *increased* [NOS] activity beyond that expected for a merely additive effect . Positive_regulation NOS1 TNF 7693276 231232 1. This study investigates the *role* of in the induction of [nitric oxide synthase (NOS)] by bacterial endotoxin ( lipopolysaccharide ; Positive_regulation NOS1 TNF 8549863 346492 Used alone or in combination , and IFN significantly *enhanced* the activity of inducible [nitric oxide synthase] as determined by measuring the conversion of 14C labeled arginine to 14C labeled citrulline and nitric oxide . Positive_regulation NOS1 TNF 8700134 375435 [NOS] *induction* by was dose dependent from concentrations of 0.06 to 60 nM and was increased 2-3-fold by IFN gamma . Positive_regulation NOS1 TNF 8737749 376968 Here we show that in cultured bovine chondrocytes and explants of human osteoarthritic cartilage both [nitric oxide synthase] and cyclooxygenase activities were *induced* by the inflammatory mediators , lipopolysaccharide , and interleukin-1 beta or . Positive_regulation NOS1 TNF 8746212 344049 Experimental and clinical evidence suggests that *induces* the expression of vascular [nitric oxide (NO) synthase] within hours and that NO released from smooth muscle cells could be involved in the pathogenesis of septic shock . Positive_regulation NOS1 TNF 8752503 343589 All epithelial cells exhibited [constitutive NOS] activity that was calcium dependent , and inducible , lesser calcium dependent activity in the *presence* of interferon-gamma , interleukin-1 beta , , and lipopolysaccharide . Positive_regulation NOS1 TNF 8779862 379920 *Roles* of IL-1 and in endotoxin induced activation of [nitric oxide synthase] in cultured rat brain cells . Positive_regulation NOS1 TNF 8779862 379933 To determine whether LPS induction of [NOS] in brain cells is *mediated* by IL-1 or , acting alone or in concert , the effects of IL-1-receptor antagonist (IL-1Ra) and of TNF-soluble receptor ( TNFsRp55 ) , presented individually and in combination , on LPS induced NOS activity were tested . Positive_regulation NOS1 TNF 8779862 379937 The results indicate that LPS induction of [NOS] activity in brain cells is *mediated* in part by both IL-1 beta and . Positive_regulation NOS1 TNF 8861703 388539 These data suggest that vasodilation by LPS is mainly due to nitric oxide predominantly synthesized by an inducible [nitric oxide synthase] , proximally *induced* by . Positive_regulation NOS1 TNF 8917029 395973 The hypothesis that in humans , *induces* vasodilation and shock through activation of inducible [nitric-oxide synthase] and subsequent formation of excessive quantities of nitric oxide is not substantiated by our results . Positive_regulation NOS1 TNF 9161719 431833 [NOS] activity was stimulated by exposure to interferon-gamma (IFN-gamma) and could be further *stimulated* by and epidermal growth factor (EGF) although neither was affective alone . Positive_regulation NOS1 TNF 9215702 441812 The isoform of the [nitric oxide synthase] *induced* in human neuroblastoma cells by treatment was identified enzymatically as isoform II by Western blotting and by the polymerase chain reaction . Positive_regulation NOS1 TNF 9294835 452984 This study suggests that dialytic `` acetate intolerance '' can be induced by the *activation* , through cAMP and release , of [NOS] . Positive_regulation NOS1 TNF 9693272 523365 Single stimulation of smooth muscle cells with either neopterin or *caused* inducible [nitric oxide synthase] gene expression and nitric oxide production . Positive_regulation NOS1 TNF 9834372 479673 *regulates* inducible [nitric oxide synthase] gene expression in the portal hypertensive gastric mucosa of the rat . Positive_regulation NOS1 TNF 9875639 557215 In transformed hepatic stellate cells , and interferon-gamma have a crucial role in nitric oxide production , and extracellular L-arginine transport and inducible [nitric oxide synthase] expression are *regulated* in a differential cytokine-specific manner . Positive_regulation NOS1 TNFSF10 11568010 864137 *stimulated* caspase 3 and [nitric oxide synthase (NOS)] activities , and both pathways cooperate in mediating inhibition of K562 survival/growth . Positive_regulation NOS1 TNFSF10 11568010 864138 Moreover , z-VAD-fmk was able to block *mediated* apoptosis and cell cycle abnormalities and increase of [NOS] activity . Positive_regulation NOS1 TNFSF10 17540725 1778503 In addition , GAPDH small interfering RNA partially prevented the apoptotic effect of TRAIL , although *induced* [nitric oxide synthase] stimulation and production of nitric oxide were not attenuated . Positive_regulation NOS2 ARSA 17218764 1664117 Furthermore , in comparison to plain ASA , caused stronger inhibition of cNOS and *increase* in [iNOS] expression in the gastric mucosa . Positive_regulation NOS2 ARSA 18077625 1868183 Therefore , <5-ASA> prevents irradiation *induced* inflammatory processes as well as expression of tumor necrosis factor alpha , monocyte chemotactic protein-1 , inducible [nitric-oxide synthase] , and macrophage infiltration . Positive_regulation NOS2 BLVRA 25206501 2886917 We hypothesize that dependent *inducible* [nitric oxide synthase] regulation strongly contributes to the cognitive improvement observed following atorvastatin treatment . Positive_regulation NOS2 CAPN8 10835326 699152 *Role* of in hypoxic inhibition of [nitric oxide synthase] activity in pulmonary endothelial cells . Positive_regulation NOS2 CAPN8 18624772 2179436 Activation of protease by oxidized and glycated LDL *increases* the degradation of endothelial [nitric oxide synthase] . Positive_regulation NOS2 CST6 11238649 790934 mRNA expression and flow cytometric analysis of infected spleen cells suggested that and IFN-gamma treatment , in addition to greatly reducing parasite numbers , *resulted* in reduced levels of IL-4 but increased levels of IL-12 and [inducible NO synthase] . Positive_regulation NOS2 EDN2 10770961 686091 Dysfunctional renal [nitric oxide synthase] as a determinant of salt-sensitive hypertension : mechanisms of renal artery endothelial dysfunction and *role* of for vascular hypertrophy and Glomerulosclerosis . Positive_regulation NOS2 EDN2 18973526 2086083 The *roles* of the receptors A and B ( ET ( A ) and ET ( B ) ) in CsA enhanced expression of PCNA and [iNOS] were examined in cultured human gingival fibroblasts pretreated with receptor antagonists , by immunocytochemistry and RT-PCR , respectively . Positive_regulation NOS2 EDN2 9473143 476304 *enhances* lipopolysaccharide induced expression of inducible [nitric oxide synthase] in rat glial cells . Positive_regulation NOS2 EDN2 9473143 476310 We found that in glial cell cultures lipopolysaccharide stimulated [inducible NO synthase] expression and nitrite accumulation were synergistically *enhanced* by pretreatment with endothelin , whereas itself did not induce these responses . Positive_regulation NOS2 EPHB2 12372406 996386 Porphyromonas gingivalis lipopolysaccharide interferes with salivary mucin synthesis through inducible [nitric oxide synthase] *activation* by and p38 kinase . Positive_regulation NOS2 EPHB2 12426209 1014369 Treatment of VSMCs with PDGF or EGF alone potently induced phosphorylation and DNA synthesis but did not *induce* NF-kappaB activation or [iNOS] expression . Positive_regulation NOS2 EPHB2 12426209 1014381 Inhibition of phosphorylation with selective inhibitors ( PD98059 or U0126 ) *attenuated* interleukin-1beta induced persistent NF-kappaB activation and [iNOS] expression in either the absence or presence of the growth factors . Positive_regulation NOS2 EPHB2 12609986 1085307 The regulation of macrophage activation by ERK appears to be selective for IL-1 , as inhibition does not *attenuate* dsRNA induced [iNOS] expression by macrophages . Positive_regulation NOS2 EPHB2 16327214 1490980 activation , [iNOS] *induction* , and NO production following LPS stimulation were all markedly inhibited in the presence of U0126 , an ERK inhibitor . Positive_regulation NOS2 EPHB2 16476053 1524214 Inhibition of activity , by the inhibitor U0126 , *reduced* LPS induced [iNOS] expression in our cell lines . Positive_regulation NOS2 EPHB2 17804409 1817448 Increased [iNOS] activity was *dependent* on B1R activation of the MAPK . Positive_regulation NOS2 EPHB2 18164123 2008038 Pretreating the macrophages with the NF-?B inhibitor , BAY 11-7082 , and the inhibitor , PD98059 , *inhibited* NO production and [iNOS] expression induced by 1-BP . Positive_regulation NOS2 EPHB2 19474186 2107589 In conclusion , this study suggests that sildenafil has antiapoptotic effects in experimental IR renal injury via phosphorylation , *induction* of [iNOS] and eNOS production , and a decrease in the Bax/Bcl-2 ratio . Positive_regulation NOS2 EPHB2 19958762 2199307 Both IL-1beta induced [iNOS] expression and NO production in ASMCs of G-K and control rats were markedly *reduced* in the presence of an inhibitor , U0126 or PD98059 . Positive_regulation NOS2 EPHB2 23143065 2717919 OPTmecAMP inactivated Raf1/MEK/ERK signaling , but *had* no effect on [iNOS] expression . Positive_regulation NOS2 EPHB2 23178030 2736153 ROS dependent stimulation of , JNK , NF-?B , and AP-1 activation *contributes* to P. acnes induced [iNOS/NO] and COX-2/PGE2 in macrophages , and chemicals such as hispolon possessing ability to block iNOS/NO and COX-2/PGE2 production reserve potential to be further developed for treatment of the early phase of inflammation elicited by P. acnes . Positive_regulation NOS2 EPHB2 23680829 2819334 IL-1 dependent upregulation of [iNOS] , IL-6 , Cox-2 , ( MMP)-3 , and MMP-13 was significantly *reduced* by inhibition . Positive_regulation NOS2 F2R 11701759 878760 Thrombin and *activating* peptide increase [iNOS] expression in cytokine stimulated C6 glioma cells . Positive_regulation NOS2 FAS 14615069 1163718 Fas receptor activation also increased the generation of reactive oxygen species , and N-acetylcysteine , a well-known antioxidant , could block mediated [iNOS] *induction* . Positive_regulation NOS2 FAS 14615069 1163721 Overall , [iNOS] *induction* and P450 3A4 suppression by activation may cause toxic cellular damage in gastrointestinal tissues . Positive_regulation NOS2 FAS 14967838 1220247 signaling *induces* Akt activation and upregulation of endothelial [nitric oxide synthase] expression . Positive_regulation NOS2 FAS 14967838 1220259 Here , we report that engagement with Fas ligand *induced* activation of Akt and upregulation of endothelial [nitric oxide synthase] expression without induction of apoptosis . Positive_regulation NOS2 FAS 15317908 1286372 Death promoting effects have been ascribed to inhibition of nuclear factor-kappaB , increase of expression , p53 stabilization , cytokine and chemokine release , and *activation* of [nitric oxide synthase] , p38 , and c-Jun-N-terminal kinase . Positive_regulation NOS2 HBEGF 23393916 2713223 These results suggest that *regulates* [iNOS] expression and NO production in adipocytes through the modulating activation of NF-kappaB and may have a potential clinical application within protocols designed for treating metabolic syndrome . Positive_regulation NOS2 HRH1 17607157 1822146 Moreover , <2-h i-I/R> *increased* the pulmonary [iNOS] mRNA expression , a fact prevented by lymphatic thoracic duct ligation . Positive_regulation NOS2 HSD11B2 19776225 2232013 Pharmacological inhibition of <11 beta-HSD1> and RNA interference against 11 beta-HSD1 *reduced* the mRNA and protein levels of [iNOS] , MCP-1 , and IL-6 . Positive_regulation NOS2 IL1B 10066820 593912 Bacterial lipopolysaccharide (LPS) or was unable to *induce* the expression of [iNOS] and the production of NO in rat C6 glial cells . Positive_regulation NOS2 IL1B 10085153 599478 Deletion analysis of the iNOS promoter/enhancer revealed that an AT-rich sequence ( -61 to -54 ) downstream of the NF-kappaB site ( -85 to -76 ) in the 5'-flanking sequence was important for [iNOS] *induction* by and endotoxin in vascular smooth muscle cells . Positive_regulation NOS2 IL1B 10193805 603753 In the present study we examined the effect of pharmacological dose of human recombinant erythropoietin ( rHuEpo ) on the *induced* NO and cGMP production as well as [inducible nitric oxide synthase (iNOS)] in cultured rat VSMC . Positive_regulation NOS2 IL1B 10193805 603754 While rHuEpo inhibited *induced* [iNOS] mRNA expression , rHuEpo vehicle did not affect IL-1beta induced iNOS mRNA expression . Positive_regulation NOS2 IL1B 10193805 603755 It is suggested that a pharmacological dose of rHuEpo inhibits *induced* NO and cGMP production as well as [iNOS] mRNA expression , presumably via the Epo receptor . Positive_regulation NOS2 IL1B 10321717 612295 can *cause* induction of [inducible nitric oxide synthase (iNOS)] expression in vascular smooth muscle cells and produce vasorelaxation , hypotension and ultimately tissue damage . Positive_regulation NOS2 IL1B 10352496 561433 LPC inhibited *stimulated* [iNOS] protein expression , whereas LPC did not inhibit IL-1 beta stimulated iNOS mRNA expression . Positive_regulation NOS2 IL1B 10365824 621119 We have previously reported that the inflammatory cytokine *induced* the expression of the inducible [nitric oxide synthase] gene in primary cultured rat hepatocytes . Positive_regulation NOS2 IL1B 10403504 629018 Nevertheless , estradiol still inhibited *induced* [iNOS] and NO production even in the presence of high glucose . Positive_regulation NOS2 IL1B 10406194 629399 *increased* levels of inducible [nitric oxide synthase] protein and inducible nitric oxide synthase mRNA , as well as nitric oxide production , in the cultured hepatocytes . Positive_regulation NOS2 IL1B 10406194 629402 FK506 markedly inhibited the nitric oxide formation , inducible nitric oxide synthase protein synthesis and inducible [nitric oxide synthase] mRNA expression *induced* by , but cyclosporin A had no effects . Positive_regulation NOS2 IL1B 10412764 630873 Lysophosphatidylcholine up-regulates *induced* [iNOS] expression in rat mesangial cells . Positive_regulation NOS2 IL1B 10412764 630874 These findings suggest that LPC may contribute to progression of glomerular inflammation by augmenting *induced* [iNOS] expression . Positive_regulation NOS2 IL1B 10433805 634068 In RIN5F cells , the activity of [iNOS] *induced* by ( 10 pM , 24 h ) , was significantly reduced by glucagon ( 1000 nM ) , which raises cyclic AMP , and by forskolin ( 1-10 microM ) , a non specific activator of adenylate cyclase . Positive_regulation NOS2 IL1B 10523329 653402 N-acetyl-L-cysteine enhances *induced* [nitric oxide synthase] expression . Positive_regulation NOS2 IL1B 10523329 653405 The effect of N-acetyl-L-cysteine on *induced* [nitric oxide synthase] expression was studied in rat vascular smooth muscle cells to determine if the reduction/oxidation state would modulate cytokine induced changes . Positive_regulation NOS2 IL1B 10572062 568673 The results show that TGF-beta(1) caused a virtually complete suppression of *induced* [iNOS] expression while preventing the decline in alpha-SMA expression or the myofibroblast subpopulation . Positive_regulation NOS2 IL1B 10593906 572865 Both p38alpha ( MAPK ) and JNK/SAPK pathways are important for *induction* of [nitric-oxide synthase] by in rat glomerular mesangial cells . Positive_regulation NOS2 IL1B 10593906 572867 *induces* expression of the [inducible nitric-oxide synthase (iNOS)] with concomitant release of nitric oxide ( NO ) from glomerular mesangial cells . Positive_regulation NOS2 IL1B 10593906 572868 Our current study demonstrates that overexpression of the dominant negative form of JNK1 or p54 SAPKbeta/JNK2 significantly reduces the [iNOS] protein expression and NO production *induced* by . Positive_regulation NOS2 IL1B 10593906 572872 Similarly , overexpression of the kinase-dead mutant form of p38alpha ( MAPK ) also inhibits *induced* [iNOS] expression and NO production . Positive_regulation NOS2 IL1B 10593906 572876 therefore , we examined the role of these MAPK kinases in the modulation of [iNOS] *induced* by . Positive_regulation NOS2 IL1B 10593906 572877 Overexpression of the dominant negative form of MKK4/SEK1 decreases *induced* [iNOS] expression and NO production with inhibition of both SAPK/JNK and p38 ( MAPK ) phosphorylation . Positive_regulation NOS2 IL1B 10593906 572880 This study suggests that the activation of both SAPK/JNK and p38alpha ( MAPK ) signaling cascades are necessary for the *induced* expression of [iNOS] and production of NO in renal mesangial cells . Positive_regulation NOS2 IL1B 10601882 574645 [iNOS] induction involves activation by phosphorylation of the MAP kinase p38 and can be *induced* in cultured astrocytes by or H2O2 . Positive_regulation NOS2 IL1B 10702213 672496 Superoxide enhances *mediated* transcription of the hepatocyte-inducible [nitric oxide synthase] gene . Positive_regulation NOS2 IL1B 10702213 672499 Using rat hepatocytes in primary culture , [iNOS] gene transcription was *induced* by . Positive_regulation NOS2 IL1B 10712388 674006 *induced* [iNOS] expression and NO generation and significantly upregulated VEGF mRNA expression and protein synthesis . Positive_regulation NOS2 IL1B 10713108 675827 Here , we address the possibility that Abeta stimulated [iNOS] expression might *result* from an initial induction of and TNFalpha . Positive_regulation NOS2 IL1B 10713108 675832 Our data suggest that Abeta stimulation of astrocyte [iNOS] is *mediated* in part by and TNFalpha , and involves a TRAF6- , TRAF2- , and NIK dependent signaling mechanism . Positive_regulation NOS2 IL1B 10748917 579745 *induces* the expression of the inducible [isoform of NO synthase (iNOS)] , which use L-arginine as substrate to overproduce NO . Positive_regulation NOS2 IL1B 10775561 686636 N-Acetyl-L-cysteine potentiates *induction* of [nitric oxide synthase] : role of p44/42 mitogen activated protein kinases . Positive_regulation NOS2 IL1B 10775561 686638 The effect of N-acetyl-L-cysteine on potentiating *induced* nitrite production and [iNOS] expression was mimicked either by the enantiomers , L-cysteine and D-cysteine , or by a non-thiol containing antioxidant , L-ascorbic acid . Positive_regulation NOS2 IL1B 10775561 686655 Inhibition of p44/42 MAPK phosphorylation by the selective inhibitor PD98059 clearly inhibited [iNOS] expression *induced* by either in the absence or in the presence of N-acetyl-L-cysteine . Positive_regulation NOS2 IL1B 10775561 686686 These observations , combined with previous results , indicate that p44/42 MAPK activation is required for *induction* of [iNOS] and that N-acetyl-L-cysteine may act as a reducing agent and facilitate interleukin-1beta induced iNOS expression through a reduction/oxidation related mechanism involving potentiation of cytokine activation of the p44/42 MAPK signaling pathway . Positive_regulation NOS2 IL1B 10793263 689610 In conclusion , a p50 and p65 NF-kappaB heterodimer binds to a reverse-NF-kappaB site on the rat iNOS promoter and contributes to [iNOS] *induction* by and IFN-gamma in RASMCs . Positive_regulation NOS2 IL1B 10843870 700349 Both toxins enhanced *stimulated* [iNOS] expression and NO production . Positive_regulation NOS2 IL1B 10861753 705330 After 4 weeks of treatment with E ( 2 ) + DHT , a significant increase in transcript levels of IL-4 , IL-5 , IL-6 , MIP-2 , eotaxin , and [iNOS] was *detected* , while and TNF-alpha transcript levels only increased slightly . Positive_regulation NOS2 IL1B 10871193 706786 However , normal *mediated* translocation of NF-kappaB and induction of inducible [nitric oxide synthase] expression and nitric oxide production was severely impaired in the INS-1res cell lines , suggesting a mechanism for the IL-1beta resistance . Positive_regulation NOS2 IL1B 10882405 709473 4. Moreover , CGP-43182 completely blocked *induced* gene expression of the inducible [nitric oxide synthase] , leading to an inhibition of cytokine stimulated nitric oxide formation . Positive_regulation NOS2 IL1B 10924055 718155 In contrast , the non-Src inhibitors TP 47/AG 213 and genistein and the tyrosine phosphatase inhibitor vanadate did not affect the spontaneous upregulation of IL-1beta mRNA but blocked both the *mediated* and spontaneous induction of [iNOS] . Positive_regulation NOS2 IL1B 10967106 751779 Inducible [nitric oxide synthase] mRNA accumulation and nitrite production , which *required* the simultaneous presence of and IFN-gamma , were also suppressed by approximately 70 % , and these cells were more resistant to cytokine induced apoptosis as compared with parental cells . Positive_regulation NOS2 IL1B 10967106 751785 These results demonstrate that is *involved* in inducible [nitric oxide synthase] gene expression and induction of apoptosis in mouse beta cells but does not contribute to impaired glucose stimulated insulin secretion . Positive_regulation NOS2 IL1B 10976000 729527 L-buthionine-S , R-sulfoximine ( BSO ) , an inhibitor of GSH synthesis , decreased *induced* nitrite release in rat islets and purified rat beta cells , nitrite formation and [iNOS] gene promoter activity in insulinoma cells , and iNOS mRNA expression in rat islets . Positive_regulation NOS2 IL1B 11024034 767724 The resistance to IL-1 beta plus IFN-gamma in STAT-1 alpha expressing cells is due in part to interference with *mediated* stimulation of inducible [nitric-oxide synthase] expression and nitric oxide production . Positive_regulation NOS2 IL1B 11046081 742870 To investigate the possible relationship between cytokine induced expression of iNOS and epithelial ion channel function , we measured whole-cell current in A549 cells treated with a mixture of cytokines : tumor necrosis factor , , and interferon-gamma for 12 h. Cytokines significantly *increased* the expression and activity of [iNOS] , and reduced generation of cGMP in response to stimulation with NO donor S-nitroso-glutathione ( GSNO ) . Positive_regulation NOS2 IL1B 11181061 785017 Expression of [inducible nitric oxide synthase (iNOS)] and subsequent NO formation *induced* by or ( IL-1 beta + IFN-gamma ) may impair islet function in rodent islets . Positive_regulation NOS2 IL1B 11191283 761392 TNF-alpha activated NF-kappaB in gel shift experiments without inducing iNOS -- as assessed by nitrite formation -- whereas *stimulated* both NF-kappaB activation and [iNOS] induction . Positive_regulation NOS2 IL1B 11216878 785911 2 ) LIF and IFN-gamma , but not , *induce* the [iNOS] mRNA expression in syncytiotrophoblast cells in vitro , suggesting possible similar regulatory mechanisms in vivo . Positive_regulation NOS2 IL1B 11222532 787684 The purpose of these studies was to investigate the *role* of interferon-gamma (IFN-gamma) , tumor necrosis factor-alpha (TNF-alpha) , , and transforming growth factor-beta ( TGF-beta ) in the regulation of inducible [nitric oxide synthase] ( NOS2 ) activity in rabbit corneal cells . Positive_regulation NOS2 IL1B 11270616 797391 Experiments using stable clones of rat C6 glioma cells transfected with dominant negative IkappaB alpha ( serines 32 and 36 replaced by alanine ) suggest that NF-kappaB activation ( phosphorylation of IkappaB alpha ) is involved in LPS/IFNgamma- or *induced* [iNOS] expression . Positive_regulation NOS2 IL1B 11275558 797843 Our results suggest that the inhibitory action of N2733 toward *induced* NF-kappaB activation and [iNOS] expression is due to its blockade of the upstream signal ( s ) leading to IKK-alpha activation , and subsequent phosphorylation and degradation of IkappaB-alpha in rat VSMCs . Positive_regulation NOS2 IL1B 11287034 799931 Aspirin dose dependently inhibits the *stimulated* increase in inducible [nitric oxide synthase] , nitric oxide , and prostaglandin E ( 2 ) production in rat ovarian dispersates cultured in vitro . Positive_regulation NOS2 IL1B 11287034 799933 Determine if aspirin inhibits the *stimulated* expression of [inducible nitric oxide synthase (iNOS)] , nitric oxide ( NO ) , and prostaglandin E ( 2 ) ( PGE ( 2 ) ) in rat ovarian dispersates cultured in vitro . Positive_regulation NOS2 IL1B 11287034 799934 Coadministration of IL-1 beta and aspirin ( 10 mM ) attenuates *stimulated* [iNOS] expression after culture for 24 and 48 hours . Positive_regulation NOS2 IL1B 11287034 799935 Aspirin significantly inhibits the *stimulated* expression of [iNOS] , NO , and PGE ( 2 ) in ovarian dispersates cultured in vitro . Positive_regulation NOS2 IL1B 11457450 838166 15-deoxy-Delta12,14-prostaglandin J2 ( 15d-PGJ2 ) , in contrast to troglitazone , was highly potent to counteract *induced* cyclooxygenase-2 and inductible [nitric oxide synthase] expression , NO production and the decrease in proteoglycan synthesis . Positive_regulation NOS2 IL1B 11474579 841778 C/EBP sites within the -205/+88 bp region were shown to be responsible , along with NF-kappaB site , for *induction* of [iNOS] promoter by . Positive_regulation NOS2 IL1B 11502570 847680 *induces* the [inducible nitric oxide synthase (iNOS)] , resulting in the release of nitric oxide ( NO ) from glomerular mesangial cells . Positive_regulation NOS2 IL1B 11502570 847681 In this study , we demonstrated that disruption of F-actin formation by sequestration of G-actin with the toxin latrunculin B ( LatB ) dramatically potentiated *induced* [iNOS] protein expression in a dose dependent manner . Positive_regulation NOS2 IL1B 11502570 847682 These data strongly suggest that actin cytoskeletal dynamics regulates *induced* [iNOS] expression . Positive_regulation NOS2 IL1B 11502570 847684 Overexpression of a dominant negative mutant of SRF increases the *induced* [iNOS] expression , providing direct evidence that SRF inhibits iNOS expression . Positive_regulation NOS2 IL1B 11506125 847934 Halothane but not isoflurane attenuates *induced* [nitric oxide synthase] in vascular smooth muscle . Positive_regulation NOS2 IL1B 11506125 847936 *induced* expression of [iNOS] and iNOS mRNA in the rat aorta were inhibited significantly by halothane . Positive_regulation NOS2 IL1B 11557585 861394 Signal transduction pathways of *mediated* [iNOS] in pulmonary vascular smooth muscle cells . Positive_regulation NOS2 IL1B 11557585 861395 In this study , overexpression of constitutively active Rac1 or its dominant negative mutant did not affect *induction* of [iNOS] . Positive_regulation NOS2 IL1B 11557585 861411 The former two pathways were not associated with mediated [iNOS] *induction* , whereas the latter two appeared to have inhibitory roles in iNOS expression . Positive_regulation NOS2 IL1B 11557585 861413 These data suggest that a broad intracellular signaling response to in rat pulmonary artery smooth muscle cells *results* in elevated levels of [iNOS] that is opposed by the geranylgeranylated small G protein Rho as well as the p38 and JAK2 pathways . Positive_regulation NOS2 IL1B 11577997 865225 Diphenyleneiodonium inhibits NF-kappaB activation and [iNOS] expression *induced* by : involvement of reactive oxygen species . Positive_regulation NOS2 IL1B 11580140 865451 In addition , it is concluded that the upregulation of iNOS in hepatocytes by LPS is caused by cytokines produced by Kupffer cells because inhibition of TNFalpha and production *attenuated* [iNOS] induction . Positive_regulation NOS2 IL1B 11730360 884949 We found that both and TNF-alpha could independently activate cytosolic NF-kappaB , direct its translocation into the nucleus , and *induce* [iNOS] monomer synthesis . Positive_regulation NOS2 IL1B 11742807 897774 Molecular mechanisms of [iNOS] *induction* by and IFN-gamma in rat aortic smooth muscle cells . Positive_regulation NOS2 IL1B 11742807 897783 We conclude that in RASMC , NF-kappa B and C/EBP mediate the *induced* [iNOS] expression , whereas IRF-1 and STAT1 mediate the IFN-gamma enhanced iNOS induction . Positive_regulation NOS2 IL1B 11742864 887435 The role of extracellular signal regulated kinase ( ERK ) was studied in the signaling pathway by which *increases* the expression of [inducible NO synthase (iNOS)] in rat vascular smooth muscle cells . Positive_regulation NOS2 IL1B 11742864 887440 Either PD98059 or U0126 , selective inhibitors of ERK activation , did not influence IL-1beta induced early activation but effectively reduced the prolonged activation of NF-kappaB and significantly reduced *induction* of [iNOS] . Positive_regulation NOS2 IL1B 11795978 902094 Recombinant equine *increased* the expression of [iNOS] in a dose dependent manner . Positive_regulation NOS2 IL1B 11853230 913346 The *induced* NO production and [iNOS] expression in vascular smooth muscle cells of SHRSP were significantly lower than those in cells of WKY . Positive_regulation NOS2 IL1B 11872267 918550 The expression of [iNOS] was *induced* by and Abeta [ 25-35 ] and was partially inhibited by treatment with WSC . Positive_regulation NOS2 IL1B 11880505 919468 In addition , we show that minocycline not only prevents MPTP induced activation of microglia but also the formation of mature and the *activation* of NADPH-oxidase and [inducible nitric oxide synthase (iNOS)] , three key microglial derived cytotoxic mediators . Positive_regulation NOS2 IL1B 11956484 931195 The induction of inducible [nitric oxide synthase] in the urothelium appears to *depend* on the synergistic effect of and TNF-alpha . Positive_regulation NOS2 IL1B 11989973 936437 Expression of [inducible nitric oxide synthase (iNOS)] and subsequent NO formation *induced* by may impair an islet function in rodents . Positive_regulation NOS2 IL1B 12062366 953178 *Induction* of [iNOS] expression in skeletal muscle by and NFkappaB activation : an in vitro and in vivo study . Positive_regulation NOS2 IL1B 12062366 953184 These data demonstrate that , together with the priming effect of gamma-IFN , *induces* [iNOS] expression in skeletal muscle via activation of ERK1/ERK2 and NFkappaB . Positive_regulation NOS2 IL1B 12110001 963237 The *induction* of the [inducible NO-synthase] by TNF-alpha , and LPS provoked a transient down-regulation of CTGF mRNA , an effect that could be partially overcome by pretreatment with the NOS-inhibitor Nomega-nitro-l-arginine methyl ester . Positive_regulation NOS2 IL1B 12120758 964999 The present study was to investigate the effect of a calcium antagonist amlodipine on nitrite , tumor necrosis factor-alpha (TNF-alpha) and formation and [iNOS] *induction* both in lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) treated rat aortic smooth muscle cells ( RASMC ) and in a rat model of endotoxemia . Positive_regulation NOS2 IL1B 12209512 983971 Epigallocatechin-3-gallate inhibits *induced* expression of [nitric oxide synthase] and production of nitric oxide in human chondrocytes : suppression of nuclear factor kappaB activation by degradation of the inhibitor of nuclear factor kappaB . Positive_regulation NOS2 IL1B 12210732 984093 On the other hand , , a Th1 proinflammatory cytokine , dramatically *increases* nitrite and nitrate levels , as well as [inducible nitric oxide synthase (iNOS)] transcripts and also upregulates islet ICAM-1 expression as well as circulating ICAM-1 levels . Positive_regulation NOS2 IL1B 12225970 987941 USF-1 and USF-2 trans-repress *induced* [iNOS] transcription in mesangial cells . Positive_regulation NOS2 IL1B 12225970 987943 These results demonstrated that USF binding to the E-box at -893/-888 serves to trans-repress basal expression and *induction* of the [iNOS] promoter . Positive_regulation NOS2 IL1B 12237341 989189 Because ICE activity is essential for the endogenous synthesis of active IL-1beta , ICE overexpression represents the key signal in the AmB induced and *mediated* effects on [iNOS] activity . Positive_regulation NOS2 IL1B 12365794 995289 in intra-islet macrophages may *induce* Fas and inducible [nitric oxide synthase] expression in an autocrine and paracrine manner and mediate beta cell destruction or even death of some macrophages and T cells . Positive_regulation NOS2 IL1B 12366506 995299 Both LPS and decreased contractility and *increased* NO production , as well as [iNOS] . Positive_regulation NOS2 IL1B 12374621 996600 Green tea polyphenol epigallocatechin-3-gallate inhibits the *induced* activity and expression of cyclooxygenase-2 and [nitric oxide synthase-2] in human chondrocytes . Positive_regulation NOS2 IL1B 12374621 996604 In the present study , we report the pharmacological effects of green tea polyphenol epigallocatechin-3-gallate ( EGCG ) , on *induced* expression and activity of cyclooxygenase-2 (COX-2) and [inducible nitric oxide synthase (iNOS)] in human chondrocytes derived from osteoarthritis ( OA ) cartilage . Positive_regulation NOS2 IL1B 12374621 996606 In addition , *induced* expression of [iNOS] and COX-2 was also markedly inhibited in human chondrocytes pretreated with EGCG ( p < .001 ) . Positive_regulation NOS2 IL1B 12384474 998796 In cultured adult rat CFbs , ( 5 ng/ml ) , but not interferon-gamma ( 10 ng/ml ) or tumor necrosis factor-alpha ( 10 ng/ml ) , *induced* [inducible NO synthase (iNOS)] expression and NO production that was associated with an increase in caspase-3 activity and apoptotic cell death . Positive_regulation NOS2 IL1B 12384474 998801 Our results demonstrate that *induced* [iNOS] expression can trigger NO-dependent apoptosis in adult CFbs , which appears to result from DNA damage and may be mediated by a p53 dependent apoptotic pathway . Positive_regulation NOS2 IL1B 12390534 1000541 In contrast , chlomethiazole and SB203580 potently inhibited the *induced* expression of c-fos and inducible [nitric oxide synthase] , as monitored by northern blot and quantitative RT-PCR , respectively . Positive_regulation NOS2 IL1B 12390534 1000544 Because *induced* expression of c-fos and inducible [nitric oxide synthase] is believed to directly contribute to the pathology of cerebral ischaemic injury , the results suggest a direct mechanism for the neuroprotective effects of chlomethiazole and SB203580 , and further establish the anti-inflammatory properties of chlomethiazole . Positive_regulation NOS2 IL1B 12426209 1014374 However , either PDGF or EGF markedly enhanced *induced* persistent NF-kappaB activation and [iNOS] expression but did not affect the early and transient NF-kappaB activation . Positive_regulation NOS2 IL1B 12426209 1014382 Inhibition of ERK phosphorylation with selective inhibitors ( PD98059 or U0126 ) attenuated *induced* persistent NF-kappaB activation and [iNOS] expression in either the absence or presence of the growth factors . Positive_regulation NOS2 IL1B 12426209 1014387 These results indicate that *induced* expression of NF-kappaB dependent genes , such as [iNOS] , is potentiated in the presence of growth factors through a mechanism requiring ERK dependent enhanced NF-kappaB activation , and the results also suggest that NF-kappaB activation is not required for PDGF or EGF to trigger DNA synthesis in VSMCs . Positive_regulation NOS2 IL1B 12466152 1063554 A unique pattern of phosphorylation determines HNF-4alpha activity as a trans-activator of *mediated* hepatocyte [iNOS] expression in the presence of oxidative stress . Positive_regulation NOS2 IL1B 12475221 1023538 In rat pancreatic islets and insulin producing cell lines , *induces* expression of inducible [nitric oxide synthase] and NO production leading to impairment of glucose stimulated insulin release and decreased cell survival . Positive_regulation NOS2 IL1B 12509805 1038765 Here we report on the roles of nuclear factor-kappaB (NF-kappaB) and mitogen activated protein ( MAP ) kinases in *induced* [iNOS] expression in adult rat astroglia . Positive_regulation NOS2 IL1B 12574151 1057796 ( 1 to 100 U/mL ) dose-dependently *stimulated* not only [iNOS] but also DDAH expression and enzyme activity , accompanied by an increase in NO metabolite and by a decrease in ADMA content in culture media . Positive_regulation NOS2 IL1B 12631052 1067501 Both LPS and reduced contractility in response to phenylephrine and *increased* NO production as well as [iNOS] expression . Positive_regulation NOS2 IL1B 12631052 1067502 LL-37 reduced both the LPS- and *induced* NO production and [iNOS] expression . Positive_regulation NOS2 IL1B 12755375 1090497 LPS and *stimulated* IL-1beta , IL-6 , IL-8 , [iNOS] and COX-2 gene expression . Positive_regulation NOS2 IL1B 12761298 1091492 Thus , it seems that the *induced* expression of [iNOS] is up-regulated in hypoxia to compensate for a decrease in the enzyme activity due to the lower availability of O ( 2 ) as a substrate , and consequently a sufficient amount of NO is produced to elevate cGMP to an adequate level . Positive_regulation NOS2 IL1B 12763754 1119678 Previously we found that *activated* [inducible nitric oxide (NO) synthase] ( iNOS ) expression and that NO production can trigger cardiac fibroblast (CFb) apoptosis . Positive_regulation NOS2 IL1B 12763754 1119680 Here , we provide evidence that angiotensin II (ANG II) significantly attenuated *induced* [iNOS] expression and NO production in CFbs while simultaneously decreasing apoptotic frequency . Positive_regulation NOS2 IL1B 12823994 1104346 Expression of iNOS protein was greatest at 4hr after addition of IL-1beta , and was nearly undetectable at 12hr . IL-1ra greatly reduced *induced* [iNOS] expression . Positive_regulation NOS2 IL1B 12823994 1104347 Lacrimal gland acinar cells are able to produce [iNOS] in *response* to the pro-inflammatory cytokine . Positive_regulation NOS2 IL1B 1378360 190621 Balloon injury and *induce* [nitric oxide synthase] activity in rat carotid arteries . Positive_regulation NOS2 IL1B 1380466 195898 Furthermore , markedly *increased* the mRNA levels of the inducible macrophage form of [nitric oxide synthase] in HIT cells . Positive_regulation NOS2 IL1B 14522818 1185777 p38alpha mutant and p38beta2 wild-type dose dependently inhibited *induced* [iNOS] expression . Positive_regulation NOS2 IL1B 14561487 1154224 However , neither JNKI1 nor JBD did influence *induced* NO synthesis or [iNOS] expression or the transcription of the genes encoding mitochondrial manganese superoxide dismutase ( MnSOD ) , catalase (CAT) , glutathione peroxidase (GPx) , glutathione-S-transferase rho (GSTrho) , heat shock protein ( HSP ) 70 , IL-1beta converting enzyme (ICE) , caspase-3 , apoptosis inducing factor ( AIF ) , Bcl-2 or Bcl-xL . Positive_regulation NOS2 IL1B 14576830 1156599 These results suggest that an activating mutation of K-ras can markedly enhance the [iNOS] expression *mediated* by or LPS , through the activation of promoters on NF-kappaB , C/EBP , and CRE-like sites , and that nitric oxide contributes to the colony formation and tumor growth of K-ras transformed cells . Positive_regulation NOS2 IL1B 14611111 1162784 NGF down-regulates *induced* TNF-alpha and [iNOS] production by OA synovial fibroblasts . Positive_regulation NOS2 IL1B 15001568 1236966 The present study examined the effect of angiotensin II on *induced* NF-kappaB activation and the subsequent expression of [inducible NO synthase (iNOS)] and vascular cell adhesion molecule-1 ( VCAM-1 ) in cultured rat vascular smooth muscle cells . Positive_regulation NOS2 IL1B 15115662 1241561 cAMP significantly inhibits *induced* [iNOS] gene expression in hepatocytes , but the signaling pathways responsible for the effect are not known . Positive_regulation NOS2 IL1B 15115662 1241563 Overexpression of c-Jun in hepatocytes inhibited *induced* nitrite accumulation and [iNOS] promoter activity while dominant negative c-Jun partially reversed the inhibitory effects of cAMP on nitrite accumulation . Positive_regulation NOS2 IL1B 15115662 1241566 We conclude that JNK signaling plays an important role in the inhibitory effects of cAMP on *induced* [iNOS] gene expression in cultured hepatocytes . Positive_regulation NOS2 IL1B 15192102 1281013 In summary , our data show that S1P trans-activates the TGF-beta receptor and triggers activation of Smads followed by activation of connective tissue growth factor gene transcription and inhibition of *induced* expression of [iNOS] , sPLA ( 2 ) , and MMP-9 . Positive_regulation NOS2 IL1B 15201138 1288923 N ( G ) -monomethyl-l-arginine , a known inhibitor of inducible nitric oxide synthetase (iNOS) , markedly inhibited *induced* [iNOS] gene expression , NO release , caspase-3 and caspase-6 activation , lamin B degradation , and loss of metabolic cell viability , indicating that the observed IL-1beta induced effects on nuclear lamin B involve the intermediacy of NO . Positive_regulation NOS2 IL1B 15389634 1366722 ( iii ) 1400W inhibited *induction* of [iNOS] , but failed to completely counteract the other cytotoxic effects ; Positive_regulation NOS2 IL1B 15450943 1300773 Inhibitory effects of epicatechin on induced *inducible* [nitric oxide synthase] expression in RINm5F cells and rat pancreatic islets by down-regulation of NF-kappaB activation . Positive_regulation NOS2 IL1B 15450943 1300784 Epicatechin significantly reduced IL-1beta induced nitrite production , iNOS protein and mRNA expressions , and it also inhibited *induced* IkappaBalpha protein degradation , NF-kappaB activation , and [iNOS] promoter activity . Positive_regulation NOS2 IL1B 15450943 1300787 These results suggest that epicatechin inhibits the *induced* [iNOS] expression by down regulating NF-kappaB activation , and protecting beta-cells from IL-1beta . Positive_regulation NOS2 IL1B 15591777 1346248 Heme oxygenase-1 attenuates *induced* [nitric oxide synthase] expression in vascular smooth muscle cells . Positive_regulation NOS2 IL1B 15591777 1346250 To characterize the role of HO-1 in the vascular inflammatory response , we examined the effect of HO-1 on the expression of [inducible nitric oxide synthase (iNOS)] *induced* by in rat vascular smooth muscle cells ( VSMCs ) . Positive_regulation NOS2 IL1B 15591777 1346253 Western blot analysis demonstrated that *induced* [iNOS] expression was significantly reduced by hemin cotreatment or adenovirus mediated HO-1 gene transfer . Positive_regulation NOS2 IL1B 15591777 1346255 Exposure of cells to CO or a CO donor , the tricarbonyldichlororuthenium ( II ) dimer , also markedly inhibited *induced* [iNOS] expression . Positive_regulation NOS2 IL1B 15591777 1346256 These data support the finding that HO-1 attenuates *induced* [iNOS] gene expression in VSMCs . Positive_regulation NOS2 IL1B 15639640 1362840 Under low and atmospheric oxygen tension , [iNOS] gene expression was *increased* by , but to a lesser extent in 21 % than in 1 or 5 % oxygen ( P < 0.01 ) . Positive_regulation NOS2 IL1B 15683716 1370646 Catalase potentiates *induced* expression of [nitric oxide synthase] in rat vascular smooth muscle cells . Positive_regulation NOS2 IL1B 15683716 1370648 Inhibition of the upstream ERK1 ,2 activator MEK1 ,2 with U0126 prevented *stimulated* [iNOS] expression , while the p38MAPK inhibitor SB03580 potentiated iNOS expression . Positive_regulation NOS2 IL1B 15683721 1370666 Consistently , JNK-I , a specific inhibitor of JNK , inhibited *mediated* activation of AP-1 and expression of [iNOS] . Positive_regulation NOS2 IL1B 15683721 1370668 However , the activation of NF-kappaB and C/EBPbeta was involved in the *induction* of [iNOS] by as well as by IL-IF . Positive_regulation NOS2 IL1B 15784009 1425011 *augmented* the expression of the catalytic gp91 subunit of NADPH oxidase , gp91phox , as well as [inducible NO synthase] in ATDC5 cells . Positive_regulation NOS2 IL1B 15963682 1423159 Inhibitory effect of Buthus martensi Karsch extracts on *induced* expression of [nitric oxide (NO) synthase] and production of NO in human chondrocytes and LPS induced NO and prostaglandin E2 production in mouse peritoneal macrophages . Positive_regulation NOS2 IL1B 16033422 1436188 In contrast , both ERK and JNK inhibitor pretreatments only partially ( approximately 50 % ) inhibited the *induced* [iNOS] expression in the spinal cord . Positive_regulation NOS2 IL1B 16123345 1449346 Overexpression of an inactive mutant of Cav-1 lacking the tyrosine phosphorylation site ( Y14F ) or an siRNA mediated Cav-1 knock down also resulted in marked attenuation of *induced* [iNOS] gene expression and NO release from these cells , thus further implicating Cav-1 in this signaling cascade . Positive_regulation NOS2 IL1B 16174862 1507569 Thus TSA diminishes *induced* [iNOS] transcription through phosphoinositide 3-kinase- and p70s6 kinase dependent pathways that increase site-specific histone H4 acetylation at the -978 to -710 region of the iNOS promoter . Positive_regulation NOS2 IL1B 16283237 1484075 The effects of MAPK inhibition on *induced* [iNOS] production and kappa B inhibitor protein ( IkappaB ) degradation were examined by western blotting . Positive_regulation NOS2 IL1B 16300639 1502899 In vivo , *stimulated* JNK and the expression of the inducible [isoform of nitric oxide synthase (iNOS)] . Positive_regulation NOS2 IL1B 16317111 1518959 We found that Y-27632 potentiated *induced* [iNOS] expression , p65 nuclear translocation , IkappaB kinase (IKK) , and NF-kappaB activation , whereas it had minimal effects on LPS induced responses . Positive_regulation NOS2 IL1B 16317111 1518962 In contrast , farnesyl transferase inhibitors blocked [iNOS] protein expression *induced* by LPS and , whereas NSC23766 had no effect . Positive_regulation NOS2 IL1B 16317111 1519008 Through abrogating this negative signaling , statins differentially regulate [iNOS] expression *induced* by LPS and in VSMCs . Positive_regulation NOS2 IL1B 16393772 1494465 Aurothiomalate , hydroxychloroquine , methotrexate and leflunomide inhibited *induced* [inducible NO synthase (iNOS)] expression and NO production in immortalized H4 chondrocytes , while penicillamine and sulfasalazine had no effect . Positive_regulation NOS2 IL1B 16436473 1554454 PKC-delta mediates activation of ERK1/2 and *induction* of [iNOS] by in vascular smooth muscle cells . Positive_regulation NOS2 IL1B 16436473 1554457 Stimulation of rat aortic VSM cells with *activated* PLC-gamma and pharmacological inhibition of PLC attenuated IL-1beta induced ERK1/2 activation and subsequent [iNOS] expression . Positive_regulation NOS2 IL1B 16452158 1554675 DTF strongly repressed *dependent* [iNOS] induction in a magnitude dependent manner . Positive_regulation NOS2 IL1B 16707097 1564050 IL-1Beta activated the extracellular signal regulated kinase 1/2 ( ERK1/2 ) , and this activation was also enhanced by H ( 2 ) S. Inhibition of ERK1/2 activation by the selective inhibitor U0126 inhibited *induced* NF-kappaB activation , [iNOS] expression , and NO production either in the absence or presence of H ( 2 ) S . Positive_regulation NOS2 IL1B 16782700 1590856 *increased* endothelial cell endothelial [nitric oxide (NO) synthase] ( eNOS ) expression but did not enhance eNOS activity as evidenced by release of NO ( x ) into conditioned medium in response to acetylcholine or shear stress . Positive_regulation NOS2 IL1B 16887914 1632446 This study was designed to evaluate whether *mediates* high-output [inducible nitric oxide synthase (iNOS)] expression and nitric oxide ( NO ) production in these specialized epithelial cells and characterize gonadotropin and cytokine-regulation of NO . Positive_regulation NOS2 IL1B 16887914 1632447 Inhibition of JNK , but not COX-2 , activity inhibits *induced* [iNOS] expression and NO production . Positive_regulation NOS2 IL1B 17015748 1629894 *induced* increased mRNA levels of MIP-2 , MCP-1 , RANTES , [inducible NO synthase (iNOS)] , and cyclooxygenase-2 (COX-2) in the IEC-18 cell line . Positive_regulation NOS2 IL1B 17031850 1708840 However , HNE strongly inhibited *induced* [iNOS] or NO production . Positive_regulation NOS2 IL1B 17031850 1708871 HNE abrogated *induced* [iNOS] expression and promoter activity mainly through NF-kappaB site ( -5,817/-5,808 ) possibly via suppression of IKKalpha induced IkappaBalpha phosphorylation and NF-kappaB/p65 nuclear translocation . Positive_regulation NOS2 IL1B 17068060 1693028 To investigate the presence and functionality of oestrogen receptor alpha ( ERalpha ) in interleukin (IL)1beta treated rabbit articular chondrocytes in culture , and to determine the mechanisms of 17beta oestradiol ( E2 ) effects on *induced* [inducible nitric oxide synthase (iNOS)] expression . Positive_regulation NOS2 IL1B 17068060 1693029 E2 decreased *induced* [iNOS] protein expression ( -40 % ) . Positive_regulation NOS2 IL1B 17095838 1644598 We found that two structurally-distinct inhibitors of sphingomyelinase activation ( e.g. , 3-O-methylsphingomyelin or desipramine ) or ceramide biosynthesis inhibitor ( e.g. , fumonisin ) failed to exert clear effects on *induced* [iNOS] expression , NO release and loss in cell viability . Positive_regulation NOS2 IL1B 17146391 1653974 Pharmacologic inhibitors such as PD98059 ( an extracellular regulated protein kinase [ ERKs ] inhibitor ) , SB203580 ( a p38 mitogen activated protein kinase [ MAPK ] inhibitor ) , SP600125 ( a c-Jun N-terminal kinases [ JNKs ] ) inhibitor ) , and LY294002 ( an inhibitor of phosphoinositide 3-kinase [ PI3 K ] ) were used to see the role of JNKs , ERKs , p38 MAPK , or PI3 K signaling pathway ( s ) in [iNOS] expression in *response* to in HEI-OC1 cells . Positive_regulation NOS2 IL1B 17146391 1653976 IL-1beta treatment also led to activation of JNKs , ERKs , and p70S6 K. Interestingly , pharmacologic inhibition of the PI3 K signaling pathway by LY294002 resulted in strong down-regulation of the *induced* expressions of [iNOS] protein and mRNA . Positive_regulation NOS2 IL1B 17146391 1653977 However , inhibition of JNKs and ERKs by SP29004 and PD98059 , respectively , had no effect on the *induced* [iNOS] expression . Positive_regulation NOS2 IL1B 17146391 1653979 These results suggest that the pro-inflammatory cytokine strongly *induces* [iNOS] expression and NO production in HEI-OC1 cells , and the induction appears to be achieved by increased iNOS transcription and activation of PI3 K signaling pathway . Positive_regulation NOS2 IL1B 17407761 1728346 Here , we report for the first time on the use of lentiviral vector based shRNA delivery to efficiently suppress the *mediated* induction of [iNOS] expression , the accumulation of nitrite and provide significant protection against the cytotoxic effects of IL-1beta exposure . Positive_regulation NOS2 IL1B 17438334 1742844 IL-22 did not stabilize necrosis factor-alpha/IFNgamma *induced* [iNOS] mRNA . Positive_regulation NOS2 IL1B 17510469 1761925 *induced* expression and activation of inducible [nitric oxide synthase] and cyclooxygenase-2 were inhibited by apoE in vascular smooth muscle cells ( VSMCs ) . Positive_regulation NOS2 IL1B 17512943 1751190 In wild-type fibroblasts , was only a weak *inducer* of [iNOS] and of NO accumulation and hypoxia alone had no significant effect on iNOS activation . Positive_regulation NOS2 IL1B 17512943 1751192 However , in combination with hypoxia extensively *stimulated* [iNOS] and NO production , and this stimulation was enhanced in SphK-1 null fibroblasts . Positive_regulation NOS2 IL1B 17543124 1762549 Malarial pigment haemozoin , IFN-gamma , TNF-alpha , and LPS do not *stimulate* expression of inducible [nitric oxide synthase] and production of nitric oxide in immuno purified human monocytes . Positive_regulation NOS2 IL1B 17620422 1798299 [Inducible nitric oxide (NO) synthase] *induction* and NO production by were impaired in STAT1 ( -/- ) islet cells . Positive_regulation NOS2 IL1B 17625924 1858006 It also inhibits *induced* expression of the pro-inflammatory genes [iNOS] and COX-2 and restores TGF-beta receptors I and II ( TGF-betaRI and RII ) mRNA levels . Positive_regulation NOS2 IL1B 17694686 1782125 IL-1beta induced NO levels and thermal hyperalgesia in rats , likely via either inhibiting the mediated p38 MAPK activation and subsequent [iNOS] *induction* , or direct attenuation of the central iNOS activity , which therefore reduces the central sensitization of inflammatory pain . Positive_regulation NOS2 IL1B 17913526 1874108 [iNOS] promoter activity *induced* by was inhibited by dexamethasone and the inhibitory effect was reversed by HDAC inhibitor trichostatin A . Positive_regulation NOS2 IL1B 17936042 1844323 Pretreatment of cells with pitavastatin resulted in up-regulation of [iNOS] *induction* by , followed by increased NO production . Positive_regulation NOS2 IL1B 17936043 1844324 Pretreatment of cells with rebamipide resulted in up-regulation of [iNOS] *induction* by , followed by increased NO production . Positive_regulation NOS2 IL1B 17965436 1850059 PAA enhanced the *mediated* induction of [iNOS] expression regarding both mRNA and protein . Positive_regulation NOS2 IL1B 18029909 1827993 Reporter gene assays showed that FXR ligands activated an FXR reporter gene and suppressed *induced* nuclear factor (NF)-kappaB activation and [iNOS] in a manner that required functional FXR and SHP . Positive_regulation NOS2 IL1B 18053091 1983969 Rottlerin , a known inhibitor of protein kinase Cdelta , also increased histone H4 acetylation , and inhibited *induced* [iNOS] expression and NO release in these cells . Positive_regulation NOS2 IL1B 18077487 1847151 stimulation *induced* expression of [iNOS] reverted by 1 and 10 mmol/l GS . Positive_regulation NOS2 IL1B 18080123 1903345 Celecoxib at 100 nM reduced the *induced* productions of MMP-1 , MMP-3 , [iNOS] , and NO , whereas indomethacin at 100 nM showed no effect . Positive_regulation NOS2 IL1B 18246123 1924614 Cell death in response to IL-1beta/IFNgamma is independent of caspases , but requires the *induced* production of [inducible nitric oxide synthase (iNOS)] and NO . Positive_regulation NOS2 IL1B 18300858 1873454 However , the high concentration of D-glucose did increase [iNOS] expression in *response* to low concentrations of IL-1beta ( 2.5 and 5 ng/ml ) , as well as the induced activation of both ERK 1/2 and NF-kappaB . Positive_regulation NOS2 IL1B 18300858 1873465 D-glucose also enhanced , concentration-dependently , the expression and activity of [iNOS] *induced* by co-incubation with ( 10 ng/ml ) . Positive_regulation NOS2 IL1B 18313411 1897481 However , *stimulated* [iNOS] mRNA expression was unaffected by CO . Positive_regulation NOS2 IL1B 18313411 1897484 CO was found to increase p38 phosphorylation and p38 inhibition using SB203580 increased [iNOS] protein levels in *response* to . Positive_regulation NOS2 IL1B 18348730 1925336 *induced* a transient increase in [iNOS] expression and stimulated the production of nitrite release . Positive_regulation NOS2 IL1B 18348730 1925337 Stimulation by either dynamic compression or SB203580 in isolation reduced the *induced* [iNOS] expression and nitrite production . Positive_regulation NOS2 IL1B 18372240 1888323 Interestingly , the anti-inflammatory cytokines IL-4 , IL-13 and IL-10 decreased *stimulated* NFkappaB activation and [iNOS] expression . Positive_regulation NOS2 IL1B 18587266 1931172 Effect of sildenafil citrate on *induced* nitric oxide synthesis and [iNOS] expression in SW982 cells . Positive_regulation NOS2 IL1B 18587266 1931173 When SW982 cells were pretreated with sildenafil citrate ( Viagra ) , a PDE5 specific inhibitor , sildenafil citrate significantly inhibited *induced* NO synthesis and [iNOS] expressions . Positive_regulation NOS2 IL1B 18827362 1970796 These data suggest that troglitazone is capable of increasing *induced* COX-2 and [iNOS] expression through an IkappaBalpha dependent mechanism in VSMC from WKY and SHR . Positive_regulation NOS2 IL1B 18836229 1971256 In addition , *upregulates* the expression of [iNOS] and COX-2 mRNA via upstream activation of p38 MAPK . Positive_regulation NOS2 IL1B 18836229 1971257 Real-time quantitative PCR analysis revealed that *enhanced* [iNOS] and COX-2 mRNA levels , with the maximum expression at 6 or 12 hours . Positive_regulation NOS2 IL1B 18957328 2014828 and tumor necrosis factor-alpha (TNF-alpha) *induced* [iNOS] gene expression and NO production , although these actions were inhibited by L-NG-monomethylarginine ( L-NMMA ) and decreased alkaline phosphatase ( ALPase ) activity . Positive_regulation NOS2 IL1B 19281374 655780 *Induction* of [iNOS] transcription in interferon-gamma primed cells by treatment with lipopolysaccharide , Salmonella sp. , or was potently inhibited by pretreatment with genistein , an isoflavone derived from the soy species genistin . Positive_regulation NOS2 IL1B 19398497 2095059 Exendin-4 inhibits *induced* [iNOS] expression at the protein level , but not at the transcriptional and posttranscriptional levels , in RINm5F beta-cells . Positive_regulation NOS2 IL1B 19398497 2095060 Therefore , the effects of EX-4 on the *induced* [iNOS] gene expression were investigated employing RINm5F beta-cells . Positive_regulation NOS2 IL1B 19398497 2095061 EX-4 inhibited *induced* [iNOS] protein expression and nitrite production . Positive_regulation NOS2 IL1B 19398497 2095062 However , northern blot and promoter analyses showed that EX-4 failed to inhibit *induced* [iNOS] mRNA expression and iNOS promoter activity . Positive_regulation NOS2 IL1B 19458323 2136077 Moreover , IL-1 alpha and *enhanced* VEGF and [iNOS] expression by murine peritoneal macrophages . Positive_regulation NOS2 IL1B 19513610 2092622 It is suggested that PDTC can inhibit NO production and [iNOS] mRNA expression *induced* by , which may provide an alternative method for the treatment of osteoarthritis . Positive_regulation NOS2 IL1B 19595066 2105455 [ Glutamine inhibits *induced* nitric oxide production and inducible [nitric oxide synthase] expression : experiment with cultured rat hepatocytes ] . Positive_regulation NOS2 IL1B 19669392 2186118 increased IkappaB-alpha expression ( p < 0.001 ) at 60 min and either *induced* [iNOS] ( p < 0.001 ) and IL-1beta ( p < 0.01 ) or inhibited IL-4 ( p < 0.05 ) expression at 360 min . Positive_regulation NOS2 IL1B 19740337 2134851 Furthermore , induction of was *necessary* for [iNOS] induction by BMP-6 . Positive_regulation NOS2 IL1B 19763723 2247723 In vitro , muscone reversed *induced* upregulation of IL-1beta , tumor necrosis factor alpha , cyclooxygenase 2 , inducible [nitric oxide synthase] , matrix metalloproteinase 13 , aggrecanase 2 , and nitric oxide and downregulation of Col2alpha1 and aggrecan . Positive_regulation NOS2 IL1B 19958762 2199305 Enhancement of *induced* [iNOS] expression in cultured vascular smooth muscle cells of Goto-Kakizaki diabetes rats . Positive_regulation NOS2 IL1B 19958762 2199306 Stimulation with *induced* [iNOS] expression , which was much greater in ASMCs from G-K rats than in ASMCs from control rats . Positive_regulation NOS2 IL1B 19958762 2199308 Both *induced* [iNOS] expression and NO production in ASMCs of G-K and control rats were markedly reduced in the presence of an ERK inhibitor , U0126 or PD98059 . Positive_regulation NOS2 IL1B 20141611 2178974 THS-78-5 was also able to attenuate induced *inducible* [nitric oxide synthase] expression and subsequent NO release . Positive_regulation NOS2 IL1B 20412328 2282333 Furthermore , both HTHQ and vitamin E attenuated *induced* [iNOS] protein expression in cultured hepatocytes , the potency of HTHQ being 10-times higher than that of vitamin E . Positive_regulation NOS2 IL1B 20541824 2301947 The expression of [iNOS] and the promoting apoptosis gene Bax and Fas were significantly *up-regulated* by the induction of and TNF-alpha . Positive_regulation NOS2 IL1B 20717505 2306732 AF pellet resulted in dose dependent [iNOS] and COX-2 expression in *response* to , stimulation , demonstrating that 1 ng/ml for 24 hours yielded a maximal response . Positive_regulation NOS2 IL1B 22126015 2514760 *induced* [iNOS] expression in human lung carcinoma A549 cells : involvement of STAT and MAPK pathways . Positive_regulation NOS2 IL1B 22126015 2514763 Use of specific chemical inhibitors for JAK1 kinase ( piceatannol ) , JAK2 kinase ( AG-490 ) , MEK1/2 ( PD98059 ) and JNK1/2 ( SP600125 ) revealed that *induced* [iNOS] expression involved signaling pathways in addition to JAK-STAT and ERK1/2-JNK1/2 activation . Positive_regulation NOS2 IL1B 22126015 2514764 Overall , these results suggested that instead of specific pharmacological inhibitors , use of chemopreventive agents with broad spectrum efficacy to inhibit *induced* signaling cascades and [iNOS] expression would be a better strategy towards lung cancer prevention and/or treatment . Positive_regulation NOS2 IL1B 7473142 331467 However , in these cells , plasma obtained from rats 1 h after administration of HP-228 prevented the *induction* of [iNOS] by both LPS and . Positive_regulation NOS2 IL1B 7487987 322996 Nicotinamide inhibits IRF-1 mRNA induction and prevents *induced* [nitric oxide synthase] expression in pancreatic beta cells . Positive_regulation NOS2 IL1B 7488131 332113 *induced* expression of [nitric oxide synthase] in rat renal mesangial cells is suppressed by cyclosporin A . Positive_regulation NOS2 IL1B 7488131 332116 Furthermore , by electrophoretic mobility shift analysis we demonstrate reduced DNA binding of the nuclear factor NF kappa B , an essential component of the *dependent* upregulation of [iNOS] gene transcription . Positive_regulation NOS2 IL1B 7504472 237418 Growth factor regulation of *induced* [nitric oxide synthase] and GTP : cyclohydrolase expression in cultured smooth muscle cells . Positive_regulation NOS2 IL1B 7505613 237679 *induces* the coexpression of both [nitric oxide synthase] and cyclooxygenase by islets of Langerhans : activation of cyclooxygenase by nitric oxide . Positive_regulation NOS2 IL1B 7505613 237683 Actinomycin D prevents *induced* iCOX and [iNOS] expression and the production of both nitrite and PGE2 by islets , suggesting that mRNA transcription is required for IL-1 beta induced expression of both iNOS and iCOX . Positive_regulation NOS2 IL1B 7506668 240009 Cyclosporin derivatives inhibit *induction* of [nitric oxide synthase] in renal mesangial cells . Positive_regulation NOS2 IL1B 7506700 244444 These findings suggest that interferon gamma directly *induces* the expression of the inducible [nitric oxide synthase] gene , whereas tumor necrosis factor-alpha and induce it , at least in part , via the induction of intermediary protein ( s ) , and that transforming growth factor-beta 1 inhibits cytokine induced nitric oxide production by blocking the posttranscriptional synthesis of inducible nitric oxide synthase . Positive_regulation NOS2 IL1B 7517798 261746 *Induction* of [nitric oxide synthase] gene by in cultured rat cardiocytes . Positive_regulation NOS2 IL1B 7517798 261754 similarly *induced* [iNOS] mRNA expression in cultured adult rat cardiocytes in a time dependent manner . Positive_regulation NOS2 IL1B 7517798 261755 Northern blotting and immunocytochemical study revealed that *induced* iNOS mRNA and [iNOS-like] immunoreactivity were exclusively localized to cardiac myocytes but also to nonmyocytes , to a lesser extent . Positive_regulation NOS2 IL1B 7517798 261761 Dexamethasone inhibited the *induced* NOx production as well as [iNOS] mRNA expression . Positive_regulation NOS2 IL1B 7517798 261766 Cycloheximide and actinomycin D completely inhibited the *induced* NOx production and [iNOS] mRNA expression . Positive_regulation NOS2 IL1B 7517798 261775 These data demonstrate that *induces* macrophage-type [iNOS] mRNA expression mainly by cardiac myocytes but also by nonmyocytes to a lesser extent , and subsequent de novo protein synthesis of iNOS leads to excessive local production of NO by cardiocytes . Positive_regulation NOS2 IL1B 7519400 265580 Tyrosine kinase involvement in *induced* expression of [iNOS] by beta-cells purified from islets of Langerhans . Positive_regulation NOS2 IL1B 7519400 265582 Both the expression of iNOS and nitrite formation induced by IL-1 beta were prevented by the mRNA transcriptional inhibitor actinomycin D . did not *induce* the expression of [iNOS] by FACS purified alpha-cells , the other major endocrine cell type of the islet . Positive_regulation NOS2 IL1B 7519400 265583 The tyrosine kinase inhibitors genistein and herbimycin A prevented *induced* expression of immunoprecipitable [iNOS] and nitrite release by islets , by insulinoma RINm5F cells , and by FACS purified beta-cells . Positive_regulation NOS2 IL1B 7519400 265584 Herbimycin A and genistein also prevented *induced* [iNOS] mRNA accumulation as determined by Northern blot analysis of total RNA isolated from RINm5F cells . Positive_regulation NOS2 IL1B 7519400 265585 These findings indicate tyrosine kinase activation participates in *induced* expression of [iNOS] by the insulin secreting beta-cell . Positive_regulation NOS2 IL1B 7520256 266272 However , following *activation* of [inducible NOS] in astrocytes by plus interferon-gamma , NMDA but not kainate neurotoxicity was markedly potentiated . Positive_regulation NOS2 IL1B 7521071 269274 Cyclic nucleotide regulation of *induced* [nitric oxide synthase] expression in vascular smooth muscle cells . Positive_regulation NOS2 IL1B 7526844 280505 Possible role of protein kinase C-epsilon isoenzyme in inhibition of *induction* of [nitric oxide synthase] in rat renal mesangial cells . Positive_regulation NOS2 IL1B 7526844 280507 Here we report that addition of the biologically active phorbol esters , phorbol 12-myristate 13-acetate ( PMA ) and phorbol 12,13-dibutyrate ( PDBu ) , dose-dependently inhibited the *stimulated* increase in [iNOS] mRNA levels and nitrite production . Positive_regulation NOS2 IL1B 7526844 280508 In contrast , a 24 h treatment of mesangial cells with PMA or PDBu , a regimen that also causes depletion of PKC-epsilon , abolished inhibition of *induced* [iNOS] expression and nitrite production . Positive_regulation NOS2 IL1B 7526844 280509 In addition , the selective PKC inhibitor calphostin C potentiated *induction* of [iNOS] activity . Positive_regulation NOS2 IL1B 7526844 280510 In summary these data suggest that *induction* of [iNOS] expression is tonically suppressed by PKC and the epsilon-isoenzyme is the most likely candidate mediating this effect . Positive_regulation NOS2 IL1B 7527554 280836 In contrast to PGE2 , a stable analog of PGI2 , carba prostacyclin , enhanced *induced* [iNOS] mRNA levels and nitrite production . Positive_regulation NOS2 IL1B 7528007 280915 We examined whether dexamethasone differentially affects [iNOS] induction in *response* to and a membrane-permeable cAMP analogue , N6,O-2'-dibutyryladenosine 3',5'-phosphate ( Bt2cAMP ) . Positive_regulation NOS2 IL1B 7528993 284180 TGF-beta dose dependently inhibited the *induced* NOx production and [iNOS] mRNA expression . Positive_regulation NOS2 IL1B 7528993 284185 These data indicate that *induces* [iNOS] gene expression and de novo synthesis of iNOS and subsequent NO generation in vascular endothelium and that TGF-beta and glucocorticoid block iNOS gene expression at the transcriptional level . Positive_regulation NOS2 IL1B 7530759 291726 In contrast , *induces* the expression of [iNOS] and also inhibits insulin secretion by both intact islets and Facs purified beta cells , whereas TNF+LPS have no inhibitory effects on insulin secretion by purified beta cells . Positive_regulation NOS2 IL1B 7533726 287713 These observations suggest that pyrrolidine dithiocarbamate prevents the *mediated* expression of the inducible [nitric oxide synthase] without affecting the activity of the constitutive enzyme in the rat aorta . Positive_regulation NOS2 IL1B 7534490 287736 These results indicate that , of the various cytokines studied , only *stimulates* [iNOS] mRNA accumulation and NO synthesis in mesangial cells . Positive_regulation NOS2 IL1B 7534708 287759 The angiotensin converting enzyme inhibitors , however , had no effects on the *induced* [inducible NO synthase] mRNA expression . Positive_regulation NOS2 IL1B 7538755 306885 Ethanol potentiates stimulated *inducible* [nitric oxide synthase] expression in cultured vascular smooth muscle cells . Positive_regulation NOS2 IL1B 7538755 306887 Ethanol ( 6.5-650 mM ) potentiated the *mediated* stimulation of [iNOS] mRNA production , the appearance of iNOS protein and the generation of nitrite and L-citrulline from smooth muscle cells in a concentration dependent manner . Positive_regulation NOS2 IL1B 7538755 306888 These results demonstrate that pharmacologically relevant concentrations of ethanol enhance the *induced* expression of the [iNOS] gene in vascular smooth muscle . Positive_regulation NOS2 IL1B 7539260 306999 We presently investigated the effects of pyrrolidine dithiocarbamate ( PDTC ) , a potent inhibitor of nuclear factor kappa B (NF-kappa B) , on the *induction* of [nitric oxide synthase] ( iNOS ) and manganese superoxide dismutase ( MnSOD ) mRNAs by in insulin producing RIN cells . Positive_regulation NOS2 IL1B 7539260 307001 PDTC decreased by 90 % both *induced* increase in medium nitrite accumulation ( an indicator of NO production ) and induction of [iNOS] mRNA expression . Positive_regulation NOS2 IL1B 7540573 310059 In conclusion , the *induced* [iNOS] cloned and expressed from rat islets and RIN cells is encoded by the same transcript as the iNOS induced in other cell types . Positive_regulation NOS2 IL1B 7543244 314249 However , the cellular mechanisms that underlie the *induction* of [iNOS] by in mesangial cells has not been clarified . Positive_regulation NOS2 IL1B 7543244 314250 Because we have shown that tyrosine kinase inhibitors attenuate IL-1 beta induced cyclooxygenase expression and prostaglandin production , we investigated the effect of tyrosine kinase inhibitors on *induced* nitrite production and [iNOS] mRNA expression in rat mesangial cells . Positive_regulation NOS2 IL1B 7543244 314251 In addition , both of these inhibitors blocked *induced* [iNOS] mRNA expression . Positive_regulation NOS2 IL1B 7586373 333760 These results indicate that Ang II upregulates *induced* [iNOS] expression in cardiac myocytes , which is mediated at least partially via activation of protein kinase C . Positive_regulation NOS2 IL1B 7588208 329807 *induced* [nitric oxide synthase] expression by rat pancreatic beta-cells : evidence for the involvement of nuclear factor kappa B in the signaling mechanism . Positive_regulation NOS2 IL1B 7686532 222268 These data demonstrate for the first time that *induces* gene expression of inducible [nitric oxide synthase] and its de novo protein synthesis in rat vascular smooth muscle cells , thereby leading to generation of nitric oxide via Ca2+/calmodulin independent and protein kinase C-independent mechanisms . Positive_regulation NOS2 IL1B 7688219 225318 Endothelial cell [nitric oxide synthase] ( the constitutive enzyme ) was stimulated with bradykinin , and vascular smooth muscle cell nitric oxide synthase ( the inducible enzyme ) was *induced* with . Positive_regulation NOS2 IL1B 7689226 225723 resulting from cleavage of pIL-1 beta by SPE B *induced* [nitric oxide synthase] activity in vascular smooth muscle cells and killed of the human melanoma A375 line . Positive_regulation NOS2 IL1B 7689587 225788 *Induction* of [nitric oxide synthase] activity in human astrocytes by and interferon-gamma . Positive_regulation NOS2 IL1B 8224196 234759 Damage also resulted following *induction* of [nitric oxide synthase] by the cytokine in both islets and HIT-T15 cells and was prevented by replacing the substrate , arginine , with nitromonomethyl arginine . Positive_regulation NOS2 IL1B 8224196 234762 Thus intracellular levels of nitric oxide generated by *induced* [nitric oxide synthase] were sufficient to cause DNA damage in islet cells and HIT-T15 cells . Positive_regulation NOS2 IL1B 8440413 213320 The purpose of this investigation was to determine if brief exposures of islets to IL-1 beta are sufficient to induce the formation of nitric oxide and to examine the signaling process associated with *induced* expression of [nitric oxide synthase] . Positive_regulation NOS2 IL1B 8552616 347237 Surprisingly , nuclear run-on transcription experiments demonstrate that dexamethasone markedly attenuates *induced* [iNOS] gene transcription . Positive_regulation NOS2 IL1B 8572246 340722 We hypothesized that *mediated* [inducible nitric oxide synthase (iNOS)] gene expression would be inhibited after induction of the heat shock response in cultured rat pulmonary artery smooth muscle cells ( RPASMC ) . Positive_regulation NOS2 IL1B 8572246 340723 Prior induction of the heat shock response inhibited *mediated* [iNOS] gene expression in a time- and dose dependent manner . Positive_regulation NOS2 IL1B 8572246 340724 We conclude that induction of the heat shock response inhibits *mediated* [iNOS] gene expression in cultured RPASMC . Positive_regulation NOS2 IL1B 8579596 350554 Two mechanistically distinct tyrosine kinase inhibitors , genistein and herbimycin A , block the *induction* of cyclooxygenase-2 (COX-2) and [inducible nitric oxide synthase (iNOS)] by in rat mesangial cells . Positive_regulation NOS2 IL1B 8602881 352089 However , only actinomycin D inhibited *stimulated* [iNOS] mRNA expression , Treatment of smooth muscle cells with IL-1beta in the presence of platelet derived growth factor or thrombin resulted in the inhibition of cytokine stimulated expression of iNOS mRNA and NO release . Positive_regulation NOS2 IL1B 8602881 352090 In contract , the concomitant exposure of smooth muscle cells to IL-1beta-and plasmin resulted resulted in the potentiation of both *stimulated* [iNOS] expression and NO generation . Positive_regulation NOS2 IL1B 8602881 352091 These results demonstrate that specific protein components of the hemostatic system regulate *stimulated* [iNOS] mRNA expression in vascular smooth muscle cells . Positive_regulation NOS2 IL1B 8630528 361261 Addition of 3-isobutyl-1-methyl xanthine resulted in a threefold reduction in the mRNA level of *induced* inducible [nitric oxide synthase] . Positive_regulation NOS2 IL1B 8635652 362077 Furthermore , *induced* higher islet [iNOS] mRNA expression and nitric oxide production from WK/Mol islets compared with BN/CR islets . Positive_regulation NOS2 IL1B 8662662 365415 We therefore evaluated the effects of antioxidants on *induced* cyclooxygenase-2 (Cox-2) and [inducible nitric-oxide synthase (iNOS)] expression in rat mesangial cells . Positive_regulation NOS2 IL1B 8662662 365421 Another antioxidant , rotenone , which inhibits reactive oxygen intermediate production by inhibiting the mitochondrial electron transport system , did not inhibit *induced* [iNOS] and Cox-2 mRNA expression but inhibited iNOS and Cox-2 protein expression , suggesting a post-transcriptional target for the inhibition of NOS and Cox-2 expression induced by IL-1beta . Positive_regulation NOS2 IL1B 8662809 367293 Suppression of *induced* [nitric-oxide synthase] promoter/enhancer activity by transforming growth factor-beta1 in vascular smooth muscle cells . Positive_regulation NOS2 IL1B 8662883 367480 In contrast , sepiapterin , which provides BH4 through the pterin salvage pathway , strongly potentiated *induced* [iNOS] expression and abrogated the inhibitory effect of DAHP . Positive_regulation NOS2 IL1B 8698225 372888 In MPN cultures , tumor necrosis factor alpha and treatment resulted in induction of MnSOD , but only IL-1beta *induced* [iNOS] . Positive_regulation NOS2 IL1B 8737749 376971 Here we show that in cultured bovine chondrocytes and explants of human osteoarthritic cartilage both [nitric oxide synthase] and cyclooxygenase activities were *induced* by the inflammatory mediators , lipopolysaccharide , and or tumor necrosis factor-alpha . Positive_regulation NOS2 IL1B 8760147 378034 Accordingly , we sought to determine a *role* for in stimulating [iNOS] transcription in cultured rat pulmonary artery smooth muscle cells ( RPASMC ) . Positive_regulation NOS2 IL1B 8760147 378036 These data document that , by itself , *increases* [iNOS] expression in RPASMC by transcriptional activation , mediated in part by NF-kappa B . Positive_regulation NOS2 IL1B 8830655 385494 TNF-alpha and synergistically *stimulate* [iNOS] transcription in rat glomerular mesangial cells . Positive_regulation NOS2 IL1B 8895359 392479 *induced* expression of [iNOS] was unchanged with the addition of LSF . Positive_regulation NOS2 IL1B 8904645 394030 In addition the interaction between cyclic AMP- and cyclic GMP elevating agonists on the *stimulated* expression of [iNOS] was examined . Positive_regulation NOS2 IL1B 8911924 395353 Lipopolysaccharide or *increased* nitrite production and [inducible NO synthase] mRNA levels , and ethanol potentiated this effect . Positive_regulation NOS2 IL1B 8977400 408785 Induction of guanosine triphosphate-cyclohydrolase by follicle stimulating hormone enhances *stimulated* [nitric oxide synthase] activity in granulosa cells . Positive_regulation NOS2 IL1B 8981400 403763 We conclude that during systemic inflammation vascular , binding to vascular and perivascular IL-1RI receptors , may *induce* perivascular [iNOS] gene expression , leading to the production of NO and modulation of the effects of IL-1 beta in the brain . Positive_regulation NOS2 IL1B 8982730 403906 *Induction* of [inducible NO synthase] in mesangial cells by leads to excessive formation of NO by the cells as measured by nitrite production . Positive_regulation NOS2 IL1B 8982730 403907 Moreover , preincubation of mesangial cells with interleukin-1 beta protects the cells from apoptosis induced by subsequent addition of exogenous NO thus suggesting that not only *triggers* the expression of [inducible NO synthase] and massive NO formation but simultaneously stimulates a protecting principle in the cells . Positive_regulation NOS2 IL1B 8982730 403908 However , whether endogenously produced NO can fulfil this function critically depends on a balance between a yet to be defined protective mechanism and [inducible NO synthase] expression in mesangial cells in *response* to and eventually other inflammatory cytokines . Positive_regulation NOS2 IL1B 8986132 404009 In RIN cells , ebselen counteracted both the expression of iNOS mRNA and the increase in nitrite production induced by 6 hr exposure to IL-beta but failed to block *induced* [iNOS] expression following 24 hr exposure to the cytokine . Positive_regulation NOS2 IL1B 9048600 416809 In adult Leydig cells , *stimulated* [iNOS] mRNA expression . Positive_regulation NOS2 IL1B 9106264 424496 The addition of 8-bromo-cyclic AMP , but not 8-bromo-cyclic GMP , was found to further enhance the expression of [iNOS] activity *induced* by and IFN-gamma co-stimulation . Positive_regulation NOS2 IL1B 9153221 431248 1 unit/ml or 150 units/ml rat IFN-gamma do not *stimulate* [iNOS] expression or nitrite production by rat islets ; Positive_regulation NOS2 IL1B 9177260 434136 In the presence of oxidative stress , *mediated* hepatocyte [iNOS] expression and NO synthesis are significantly increased . Positive_regulation NOS2 IL1B 9177260 434137 These data indicate that BZT mediated oxidative stress increases *induced* [iNOS] gene transcription and iNOS promoter activity . Positive_regulation NOS2 IL1B 9202213 439966 Addition of IFN-gamma , before or after arrest of *induced* [iNOS] gene transcription by actinomycin D , did not prolong iNOS mRNA half life in the rat insulin producing cell line RINm5F ( RIN cells ) . Positive_regulation NOS2 IL1B 9231726 444925 The inhibitory effect of ET on *stimulated* [iNOS] expression appears to be mediated by ET ( B ) receptors , because ( 1 ) both ET-1 and ET-3 inhibited the effects of TNF-alpha/IL-1beta on iNOS expression and nitrite accumulation , ( 2 ) a selective ET ( B ) receptor agonist , Suc- [ Glu ( 9 ) , Ala ( 11,15 ) ] -ET-1 ( 8-21 ) ( IRL1620 ) , decreased the effects of TNF-alpha/IL-1beta , and ( 3 ) a selective ET ( B ) receptor antagonist , N-cis-2,6-dimethylpiperidinocarbonyl-L-gamma-methylleucyl-D- 1-methoxycarbonyltryptophanyl-D-norleucine , abolished the inhibitory effects of ETs and IRL1620 . Positive_regulation NOS2 IL1B 9237621 445652 *Induction* of inducible [nitric oxide synthase] by tumor necrosis factor-alpha , interferon-gamma and inhibited cell proliferation and led to a G1 arrest . Positive_regulation NOS2 IL1B 9259476 448704 Furthermore , our results indicate a decisive *role* of in [iNOS] expression and NO generation . Positive_regulation NOS2 IL1B 9315292 455766 Tumor necrosis factor-alpha and are *involved* in the induction of [iNOS] gene as well as the immune system . Positive_regulation NOS2 IL1B 9323084 456531 These data indicate that *induces* [iNOS] gene expression , de novo synthesis of iNOS protein , and NO generation in neonatal rat cardiomyocytes and that chronic hypoxia appears to be a potent negative regulator of iNOS expression in these cells . Positive_regulation NOS2 IL1B 9328802 457357 These results indicate that AVP inhibits *induced* [iNOS] expression in VSMCs through the V1a receptor , which is mediated at least partially via activation of protein kinase C . Positive_regulation NOS2 IL1B 9331934 457589 In the present study using primary human fetal astrocyte cultures , we found that *stimulated* activation of nuclear factor kappa B (NF-kappa B) within 2 h , [iNOS] mRNA expression at 8 h , and maximal NO production by 5 days post-treatment . Positive_regulation NOS2 IL1B 9339386 458455 Transforming growth factor-beta 2 inhibits *induced* expression of inducible [nitric oxide synthase] in rat renal mesangial cells . Positive_regulation NOS2 IL1B 9369264 463998 These results support the hypothesis that the heart may be a target organ for AVP and that AVP modulates *induced* [iNOS] expression in myocytes through the V1a receptor , which is mediated at least partially via activation of protein kinase C . Positive_regulation NOS2 IL1B 9369275 464003 Exogenous angiotensin II inhibited *stimulated* inducible [nitric oxide synthase] protein expression in both deendothelialized vessels and those with endothelium , although with reduced ability on the aortic segments with endothelium by a nitric oxide independent mechanism . Positive_regulation NOS2 IL1B 9369275 464006 In the aortic rings with endothelium , either inhibition of the AT-1 receptor with losartan or blocking of angiotensin II generation with fosinopril enhanced stimulated *inducible* [nitric oxide synthase] protein expression . Positive_regulation NOS2 IL1B 9375806 465364 The protective effects of IRAP correlate with an inhibition of *induced* [iNOS] expression by islets and FACS purified beta-cells . Positive_regulation NOS2 IL1B 9395303 468382 Insulin-like growth factor I reverses inhibition of insulin secretion , *induction* of [nitric oxide synthase] and cytokine mediated apoptosis in rat islets of Langerhans . Positive_regulation NOS2 IL1B 9436821 474859 The *stimulated* increase in nitrite formation , [iNOS] protein , and mRNA abundance in VSMCs was significantly augmented in the presence of thiopental ( 100 microM ) , whereas methohexital , hexobarbital , pentobarbital , and phenobarbital were without effect . Positive_regulation NOS2 IL1B 9442805 475262 It has been shown that the [inducible nitric oxide synthase (iNOS)] is *induced* in islets of Langerhans by . Positive_regulation NOS2 IL1B 9500699 490946 Although previous work has indicated the requirement for multiple proinflammatory cytokines to induce hepatocyte NO production , investigators have recently shown that alone can *initiate* [iNOS] expression . Positive_regulation NOS2 IL1B 9500699 490948 On the basis of the known ability of IL-1beta to induce transcription and translation of the IFN family of genes , we hypothesized that *mediated* hepatocyte expression of [iNOS] is dependent on endogenous IFN-gamma synthesis . Positive_regulation NOS2 IL1B 9500699 490951 Parallel experiments examining IL-1beta mediated endogenous hepatocyte IL-1beta and TNF-alpha synthesis indicated no role for these cytokines in the *induction* of [iNOS] expression by . Positive_regulation NOS2 IL1B 9551998 499171 *Induction* of [inducible nitric-oxide synthase (iNOS)] , IL-1beta , and IL-8 genes by , TNF-alpha , or PMA was blocked in Ad5 IkappaB infected cells but not in Ad5 LacZ controls as assayed by RT-PCR and ELISA . Positive_regulation NOS2 IL1B 9559891 500249 Western blot analysis of rat aorta homogenates revealed that 17beta-oestradiol treatment resulted in a reduction in *induced* [iNOS] protein level . Positive_regulation NOS2 IL1B 9568691 501329 The current studies were designed to characterize the involvement of protease ( s ) in the signaling pathway of *induced* [iNOS] and COX-2 expression by rat islets and transformed rat pancreatic beta-cells . Positive_regulation NOS2 IL1B 9568691 501333 The transcription factor NFkappaB is essential for activation of a number of cytokine-inducible enzymes and was evaluated as a possible site of protease action necessary for *induced* coexpression of [iNOS] and COX-2 . Positive_regulation NOS2 IL1B 9568691 501340 This study also suggests that *induced* [iNOS] and COX-2 coexpression by pancreatic beta-cells share a common signaling pathway in utilizing the proteasome complex ( 26S ) and the transcription factor NFkappaB , and it identifies sites of intervention to prevent the overproduction of their inflammatory products . Positive_regulation NOS2 IL1B 9575890 502708 The inflammatory cytokine *induces* both cyclooxygenase-2 (Cox-2) and the [inducible nitric oxide synthase (iNOS)] with concomitant release of PGs and nitric oxide ( NO ) by glomerular mesangial cells . Positive_regulation NOS2 IL1B 9575890 502711 We demonstrate that both insulin and IGF-I increase *induced* Cox-2 and [iNOS] protein expression , which in turn enhance PGE2 and NO production . Positive_regulation NOS2 IL1B 9576743 502863 Treatment of INS-1 cells with L-NMMA , an inhibitor of iNOS , provides the same degree of protection against IL-1beta or supernatants from LPS activated rat PBMC as MnSOD overexpression , supporting the idea that MnSOD protects INS-1 cells by interfering with the normal *mediated* increase in [iNOS] . Positive_regulation NOS2 IL1B 9590244 504773 Expression of the [inducible nitric oxide synthase (iNOS)] gene in rat mesangial cells is differentially *triggered* by and cAMP predominantly at the transcriptional level . Positive_regulation NOS2 IL1B 9590244 504774 Moreover , a minimal promoter ranging from the transcriptional start site up to -111 containing a kappaB site is sufficient to confer *mediated* [iNOS] promoter activation . Positive_regulation NOS2 IL1B 9650577 515401 Treatment of the cells with the A2A receptor agonist CGS 21680 inhibited both NO production and [iNOS] expression *induced* by stimulation with either LPS/IFN-gamma or , whereas the A1 and A3 receptor agonists , CPA and Cl-IB-MECA , respectively , did not have significant inhibitory effects . Positive_regulation NOS2 IL1B 9652398 515856 However , in these cells , *induction* of inducible [nitric oxide synthase] , granulocyte-macrophage colony stimulating factor and cyclooxygenase-2 mRNA showed 70-90 % repression by dexamethsone . Positive_regulation NOS2 IL1B 9661135 518080 To elucidate the effect of atrial natriuretic peptide (ANP) on cytokine induced nitric oxide ( NO ) production , we examined whether ANP affects *stimulated* NO production and [inducible NO synthase (iNOS)] mRNA expression in cultured rat vascular smooth muscle cells ( VSMC ) . Positive_regulation NOS2 IL1B 9661135 518082 ANP ( 10 nM to 1 mM ) enhanced the nitrite production and [iNOS] mRNA expression in the *presence* of . Positive_regulation NOS2 IL1B 9696008 524410 also *induced* NO production and [inducible NO synthase (iNOS)] gene expression . Positive_regulation NOS2 IL1B 9696008 524411 IL-1beta-receptor antagonist (IL-1ra) , which interferes with the interaction of IL-1beta with target cells , also abolished the inhibitory effects of IL-1beta on hepatocyte DNA synthesis as well as *induced* [iNOS] gene expression . Positive_regulation NOS2 IL1B 9718067 528140 The enhancement of NO production occurs dependent of the effects of these agents on *induction* of [inducible nitric oxide synthase (iNOS)] expression by . Positive_regulation NOS2 IL1B 9724162 529375 NO production and [iNOS] mRNA transcriptional levels in Kupffer cells were markedly *increased* by stimulation with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) , and moderately by . Positive_regulation NOS2 IL1B 9753298 533906 CNTF potentiated IL-1beta mediated NO synthesis from RIN-5AH cells by 83 % , and *induced* islet [inducible NO-synthase (iNOS)] mRNA expression fourfold . Positive_regulation NOS2 IL1B 9754830 535228 In human islet cells both and IFN-gamma are *required* for [iNOS] expression . Positive_regulation NOS2 IL1B 9754830 535230 Site-mutation analysis showed that both the distal and proximal NF-kappaB and GAS are necessary for *induced* [iNOS] expression in RINm5F cells . Positive_regulation NOS2 IL1B 9754830 535236 In primary beta cells both NF-kappaB binding sites are required for *induced* [iNOS] promoter activation . Positive_regulation NOS2 MAOA 15490317 1321354 In the course of a screening of plant extracts for potential CNS and anti-inflammatory activities , a dichloromethane extract of Salvia miltiorrhiza showed a pronounced inhibitory effect on recombinant and on [inducible NO synthase (iNOS)] *induction* in Raw 267.4 cells . Positive_regulation NOS2 MAP2K6 19288477 2063888 Here we found that US-mediated [inducible nitric oxide synthase (iNOS)] expression was *attenuated* by Ras inhibitor ( manumycin A ) , Raf-1 inhibitor ( GW5074 ) , inhibitor ( PD98059 ) , NF-kappaB inhibitor ( PDTC ) , and IkappaB protease inhibitor ( TPCK ) . Positive_regulation NOS2 MAP2K6 19457095 2107236 In addition , over-expression of MAPK kinase 1 ( MEK1 ) , MEK3 , , and MEK kinase significantly *increased* [iNOS] expression and NO production in glial cells . Positive_regulation NOS2 PGC 21435455 2406403 In addition to inactivation of forkhead transcription factor signaling through enhanced Akt/protein kinase B expression , in glycolytic muscles , overexpression *led* to enhanced expression of inducible nitric oxide synthase and endothelial [nitric oxide synthase] , production of nitric oxide , and expression of antioxidant enzyme including superoxide dismutases ( SOD1 , SOD2 , and SOD3 ) and catalase , and reduced oxidative stress . Positive_regulation NOS2 PLAT 17717150 1801528 In conclusion , our results demonstrate that after MCAO the interaction between and LRP *results* in NF-kappaB activation in astrocytes and induction of inducible [nitric-oxide synthase] expression in the ischemic tissue , suggesting a cytokine-like plasminogen independent role for tPA during cerebral ischemia . Positive_regulation NOS2 PLAU 21540184 2444674 ( uPA ) *induces* pulmonary microvascular endothelial permeability through low density lipoprotein receptor related protein ( LRP ) -dependent activation of endothelial [nitric-oxide synthase] . Positive_regulation NOS2 PTGER2 15920732 1445798 We demonstrated that microglial was *necessary* for lipopolysaccharide (LPS) activated microglia mediated neurotoxicity , as well as induction of [inducible nitric oxide synthase (iNOS)] and cyclooxygenase 2 (COX-2) . Positive_regulation NOS2 S100B 10627310 658981 The astrocyte derived *stimulates* production of inducible [nitric oxide synthase] and nitric oxide ( NO ) in astrocytes [ Hu et al. , 1996 , J. Biol. Chem. 271 : 2543 ] , but its effect on microglia is not known . Positive_regulation NOS2 S100B 11578775 865299 also *stimulated* both [iNOS] and IL-1 beta , although S100B83stop was significantly less effective than wild-type S100B in inducing iNOS . Positive_regulation NOS2 S100B 11705636 879420 As a first step toward elucidating the mechanisms by which S100B might be serving this detrimental role , we examined the mechanisms by which *stimulates* glial [inducible nitric oxide synthase (iNOS)] , an oxidative stress related enzyme that has been linked to neuropathology through the production of neurotoxic peroxynitrite . Positive_regulation NOS2 S100B 11705636 879421 We report here that *stimulates* [iNOS] in rat primary cortical astrocytes through a signal transduction pathway that involves activation of the transcription factor NFkappaB . Positive_regulation NOS2 S100B 11705636 879422 Furthermore , *induced* [iNOS] promoter activation was inhibited upon mutation of the NFkappaB response element in the promoter , and transfection of cells with an NFkappaB inhibitor blocked S100B induced iNOS promoter activation and nitric oxide production . Positive_regulation NOS2 S100B 12045670 950150 An astrocytic protein *enhances* the expression of inducible [nitric oxide synthase] in cultured astrocytes at micromolar concentrations , leading to nitric oxide mediated death of cocultured neurons . Positive_regulation NOS2 S100B 16376947 1547168 Our results demonstrate that *stimulates* both NO production and [iNOS] protein transcription and expression in J774 and rat peritoneal macrophages . Positive_regulation NOS2 S100B 19558426 2142523 Exogenous *induced* a significant increase in both [iNOS] expression and NO production in controls and UC patients ; Positive_regulation NOS2 S100B 8576219 350270 *stimulates* inducible [nitric oxide synthase] activity and mRNA levels in rat cortical astrocytes . Positive_regulation NOS2 S100B 8576219 350274 Our data indicate that can *induce* a potent activation of [inducible NOS] in astrocytes , an observation that might have relevance to the role of S100 beta in neuropathology . Positive_regulation NOS2 S100B 9375660 465348 Recent data have demonstrated that treatment of cultured rat astrocytes with high concentrations of *results* in a potent activation of [inducible nitric oxide synthase (iNOS)] and a subsequent generation of nitric oxide ( NO ) , which can lead to astrocytic cell death . Positive_regulation NOS2 SPHK1 11815603 922500 In contrast , enforced expression of *had* no effect on [iNOS] expression or NO formation . Positive_regulation NOS2 SPHK1 16269668 1502336 Endothelial [nitric oxide synthase] *activation* by tumor necrosis factor alpha through neutral sphingomyelinase 2 , , and sphingosine 1 phosphate receptors : a novel pathway relevant to the pathophysiology of endothelium . Positive_regulation NOS2 SPHK1 16857953 1600465 *dependent* activation of endothelial [nitric oxide synthase] by angiotensin II . Positive_regulation NOS2 SPHK1 17512943 1751184 To determine whether *regulates* cell proliferation and the proinflammatory protein [inducible nitric oxide synthase (iNOS)] , we exposed cultured cardiac fibroblasts to the cytokine interleukin-1beta (IL-1beta) and/or hypoxia . Positive_regulation NOS2 SPHK1 20036321 2200446 Suppression of by its inhibitor , N , N Dimethylsphingosine ( DMS ) , or siRNA *resulted* in decreased mRNA expression of TNF-alpha , IL-1beta , and [iNOS] and release of TNF-alpha and nitric oxide ( NO ) in LPS activated microglia . Positive_regulation NOS2 STK39 18621907 1966361 Together , the data demonstrate a central *role* of in the upregulation of both arginase II and [iNOS] in bPAEC in response to L/T treatment . Positive_regulation NOS2 TLR7 10426995 632968 Several lipoproteins stimulated *dependent* transcription of inducible [nitric oxide synthase] and the production of nitric oxide , a powerful microbicidal pathway . Positive_regulation NOS2 TLR7 15994412 1447003 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for tumor necrosis factor ( TNF-alpha ) , interleukin 6 , [nitric oxide synthase-II] ( iNOS ) , and NADPH oxidase 2 (Nox2) . Positive_regulation NOS2 TLR7 18250410 1865256 Previous pharmacologic studies have suggested that a PI3K-Akt pathway negatively regulates *induced* [inducible NO synthase] expression and cytokine production . Positive_regulation NOS2 TLR7 20138367 2227238 Nevertheless *mediated* JNK activation as well as the increased protein expression of [iNOS] and COX-2 remained unchanged when Syk protein was knockdown by siRNA approach . Positive_regulation NOS2 TNF 10084320 599195 A strong effect on inducible [nitric oxide synthase] gene expression could be *detected* when the cells were coincubated with the proinflammatory cytokines interferon-gamma and with inducible nitric oxide synthase cDNA concentrations averaging 11.7 +/- 0.6 amol per microg total RNA at 24 h , and 25.0 +/- 1.4 amol per microg total RNA at 48 h , respectively . Positive_regulation NOS2 TNF 10198298 605156 However , when used in combination , , IFN-gamma , and LPS markedly and synergistically *increased* [iNOS] activity in these cells . Positive_regulation NOS2 TNF 10356322 618389 We investigated the molecular mechanism for the synergistic *induction* of inducible [nitric oxide synthase] transcription by and IFN-gamma . Positive_regulation NOS2 TNF 10417671 631636 Treatment with anti-TNF-alpha mAb did not affect the expression of IFN-gamma in the LPC but inhibited expression of iNOS in the infected mice , indicating the *role* of in the induction of [iNOS] . Positive_regulation NOS2 TNF 10462263 639973 [iNOS] mRNA levels were *increased* by , and were abruptly diminished after OP mRNA was significantly induced . Positive_regulation NOS2 TNF 10470105 641369 Simultaneously , *stimulated* induction of [iNOS] and generation of NO.. Positive_regulation NOS2 TNF 10496923 647233 Hepatocyte [iNOS] *induced* by recombinant mouse was also inhibited by DEM treatment . Positive_regulation NOS2 TNF 10601128 574254 Salicylate treatment inhibited [iNOS] expression *induced* by and IFN-gamma and attenuated the phosphorylation of ERK by TNF-alpha and IFN-gamma either alone or in combination . Positive_regulation NOS2 TNF 10705297 673073 Therefore , in the present study , we investigated the *role* of endogenous IFN-gamma , and IL-10 in the regulation of LPS induced tissue [iNOS] expression in the major organs . Positive_regulation NOS2 TNF 10705297 673086 In contrast , blocking both mediators nearly completely prevents iNOS expression after LPS challenge , suggesting that the presence of either IFN-gamma or is *essential* for LPS induced [iNOS] expression in these organs . Positive_regulation NOS2 TNF 10713108 675821 Beta-amyloid stimulation of inducible [nitric-oxide synthase] in astrocytes is interleukin-1beta- and *dependent* , and involves a TNFalpha receptor associated factor- and NFkappaB inducing kinase dependent signaling mechanism . Positive_regulation NOS2 TNF 10713108 675826 Here , we address the possibility that Abeta stimulated [iNOS] expression might *result* from an initial induction of IL-1beta and . Positive_regulation NOS2 TNF 10713108 675828 We find that in Abeta stimulated astrocyte cultures , IL-1beta and production occur before iNOS production , new protein synthesis is *required* for increased [iNOS] mRNA levels , and the IL-1 receptor antagonist IL-1ra can inhibit nitrite accumulation . Positive_regulation NOS2 TNF 10713108 675831 Our data suggest that Abeta stimulation of astrocyte [iNOS] is *mediated* in part by IL-1beta and , and involves a TRAF6- , TRAF2- , and NIK dependent signaling mechanism . Positive_regulation NOS2 TNF 10728381 678157 *induced* a concentration dependent increase in [iNOS] mRNA expression and nitrite production as well as significant apoptosis of cardiomyocytes in the wild type mice ( n = 4 , P < 0.01 ) . Positive_regulation NOS2 TNF 10729362 678233 We used the reverse transcriptase-polymerase chain reaction ( RT-PCR ) to identify the subtypes of NO synthase that were expressed in the ST2 cells and we detected the expression of an [inducible NO synthase] gene in *response* to . Positive_regulation NOS2 TNF 10788433 688675 Treatment with the antioxidant pyrrolidine dithiocarbamate , which is known to inhibit NF-kappaB and sphingomyelinase in C6 cells , or with the peptide SN-50 , which blocks translocation of NF-kappaB to the nucleus , inhibited *dependent* [iNOS] mRNA expression without affecting GTPCH mRNA levels . Positive_regulation NOS2 TNF 10807663 692264 However , alone did not *induce* [iNOS] promoter activity , protein expression , or nitrite production , indicating that NF-kappaB activation alone is not sufficient for iNOS induction . Positive_regulation NOS2 TNF 10824457 696244 Dexamethasone decreased CBF at a concentration of 10 ( -6 ) M. Fluorescent immunohistochemistry demonstrated that the expression of [inducible NOS] was *augmented* by and attenuated by dexamethasone , whereas that of endothelial NOS remained unchanged . Positive_regulation NOS2 TNF 10839591 698187 In the relationship between cardiomyopathy and encephalopathy , the *activation* of [iNOS] by may have a significant pathogenetic role in HIV disease . Positive_regulation NOS2 TNF 10861753 705329 After 4 weeks of treatment with E ( 2 ) + DHT , a significant increase in transcript levels of IL-4 , IL-5 , IL-6 , MIP-2 , eotaxin , and [iNOS] was *detected* , while IL-1beta and transcript levels only increased slightly . Positive_regulation NOS2 TNF 10929773 719751 Ultraviolet B radiation downregulates inducible [nitric oxide synthase] expression *induced* by interferon-gamma or in murine keratinocyte Pam 212 cells . Positive_regulation NOS2 TNF 10929773 719755 UVBR also downregulated IFN-gamma- or *induced* [iNOS] expression at both the mRNA level and the protein level . Positive_regulation NOS2 TNF 10929773 719756 These findings suggest the possibility that the down-regulatory effect of UVBR on IFN-gamma- or *induced* [iNOS] expression may , in part , explain the antiinflammatory and therapeutic properties of UVBR in inflammatory dermatoses . Positive_regulation NOS2 TNF 11002413 767498 alone neither *induced* [iNOS] in USAC cells nor caused production of NO , but addition of TNF-alpha to USAC cells pretreated with LPS and IFN-gamma enhanced the expression of iNOS mRNA , induced iNOS protein and produced NO . Positive_regulation NOS2 TNF 11003590 734696 Moreover , Western blot analysis clearly showed that alone *induces* the expression of [iNOS] after 12-24 h treatment of differentiated 3T3F442A cells . Positive_regulation NOS2 TNF 11046081 742868 To investigate the possible relationship between cytokine induced expression of iNOS and epithelial ion channel function , we measured whole-cell current in A549 cells treated with a mixture of cytokines : , interleukin-1 beta , and interferon-gamma for 12 h. Cytokines significantly *increased* the expression and activity of [iNOS] , and reduced generation of cGMP in response to stimulation with NO donor S-nitroso-glutathione ( GSNO ) . Positive_regulation NOS2 TNF 11085984 786352 *Activation* of the endothelial [nitric-oxide synthase] by . Positive_regulation NOS2 TNF 11095498 755265 and nerve growth factor synergistically *induce* [iNOS] in pheochromocytoma cells . Positive_regulation NOS2 TNF 11095498 755268 [Inducible nitric oxide synthase (iNOS)] has been reported in tangle bearing neurons of patients with Alzheimer 's disease ( AD ) , and can be *induced* by . Positive_regulation NOS2 TNF 11095498 755270 We found that while and NGF alone were unable to *induce* [iNOS] , their simultaneous addition resulted in iNOS induction and the release of nitric oxide . Positive_regulation NOS2 TNF 11095498 755272 Our results suggest that synergistic [iNOS] *induction* by and NGF may occur in selective population of NGF-responsive neurons in the presence of elevated CNS levels of TNFalpha . Positive_regulation NOS2 TNF 11103793 756365 These results led us to conclude that IFN-gamma treated RAW 264.7 cells release to *induce* [iNOS] expression in promoter-sensitive JB6 cells . Positive_regulation NOS2 TNF 11160388 781724 beta-Amyloid stimulation of microglia and monocytes results in *dependent* expression of inducible [nitric oxide synthase] and neuronal apoptosis . Positive_regulation NOS2 TNF 11176169 779541 However , PCT ameliorated *induced* [iNOS] gene expression in a dose dependent manner ( maximal inhibition at PCT 100 ng/mL by -66 % for 24 hrs and -80 % for 48 hrs ) . Positive_regulation NOS2 TNF 11181643 785301 In addition to their other functions , and IFN-gamma both *induce* the [inducible nitric oxide (NO) synthase] ( iNOS ) . Positive_regulation NOS2 TNF 11191283 761399 However , both ceramide and potentiated IL-1beta- *induced* activation of NF-kappaB and [iNOS] . Positive_regulation NOS2 TNF 11192310 779551 The hypothesis of this study was to determine if would *stimulate* [iNOS] and its product nitric oxide ( NO ) similarly in immortalized macrophage and cardiac myocytes . Positive_regulation NOS2 TNF 11192310 779552 The expression of [iNOS] in the cardiac myocyte did not *increase* with and LPS . Positive_regulation NOS2 TNF 11192310 779554 This study suggests that HL-1 myocyte [iNOS] can not be *induced* by , unlike macrophage iNOS . Positive_regulation NOS2 TNF 11216573 763935 Both double combinations of TNFalpha + IFNgamma and IL-1beta + IFNgamma were able to induce [iNOS] mRNA expression , but only + IFNgamma *induced* significant NO production . Positive_regulation NOS2 TNF 11224628 787969 In contrast , [nitric oxide synthase] expression is *induced* by IL-1 , , and gamma interferon , a T-helper 1 cytokine profile . Positive_regulation NOS2 TNF 11399519 824230 Interferon (IFN)-gamma and Herpes simplex synergistically *induce* [nitric oxide synthase] 2 in macrophages through cooperative action of nuclear factor-kappa B and IFN regulatory factor-1 . Positive_regulation NOS2 TNF 11453704 837107 Furthermore , co-incubating S. typhimurium with Mphi resulted in interleukin (IL)-12p40 , IL-6 and production as well as [iNOS] *induction* while IL-12p70 was not detectable . Positive_regulation NOS2 TNF 11474215 841761 Also , *induced* [iNOS] gene expression in anterior pituitary cells as assessed by reverse transcriptase-polymerase chain reaction . Positive_regulation NOS2 TNF 11474215 841763 The current results indicate that NO is involved in the inhibitory effect of TNF-alpha on prolactin secretion and that *induces* [iNOS] transcription and stimulates NO synthesis in anterior pituitary cells . Positive_regulation NOS2 TNF 11517169 851237 This action of GH may be sufficient to suppress the synergistic *induction* of inducible [nitric oxide synthase] by interferon-gamma and , thereby preventing the cytotoxicity to beta-cells . Positive_regulation NOS2 TNF 11521163 852422 These effects may be mainly due to inhibition of formation and of the *induction* of [iNOS] . Positive_regulation NOS2 TNF 11535575 854733 These observations strongly suggest that APC *inhibits* [iNOS] induction by decreasing production , leading to the prevention of ET-induced hypotension . Positive_regulation NOS2 TNF 11580140 865450 In addition , it is concluded that the upregulation of iNOS in hepatocytes by LPS is caused by cytokines produced by Kupffer cells because inhibition of and IL-1beta production *attenuated* [iNOS] induction . Positive_regulation NOS2 TNF 11730360 884948 We found that both IL-1beta and could independently activate cytosolic NF-kappaB , direct its translocation into the nucleus , and *induce* [iNOS] monomer synthesis . Positive_regulation NOS2 TNF 11776329 890643 *induces* [iNOS] , thereby contributing to the development of shock . Positive_regulation NOS2 TNF 11815603 922499 In C6 glioma cells , the sphingolipid second messenger ceramide potentiates expression of [inducible nitric-oxide synthase (iNOS)] *induced* by without affecting GTP cyclohydrolase I (GTPCH) , the rate limiting enzyme in the biosynthesis of 6 ( R ) -5,6,7,8-tetrahydrobiopterin ( BH ( 4 ) ) , a cofactor required for iNOS activity . Positive_regulation NOS2 TNF 11827697 909437 In the myocardium , *enhances* the expression of [inducible nitric oxide synthase (iNOS)] . Positive_regulation NOS2 TNF 11956484 931194 The induction of inducible [nitric oxide synthase] in the urothelium appears to *depend* on the synergistic effect of IL-1beta and . Positive_regulation NOS2 TNF 11976279 934398 Western blot analysis and immunohistochemistry revealed that plus interferon-gamma (IFNgamma) synergistically *induce* [iNOS] gene expression in the endothelium but not in the smooth muscle of these segments while constitutive endothelial NO synthase (eNOS) abundance was markedly reduced . Positive_regulation NOS2 TNF 12120758 964998 The present study was to investigate the effect of a calcium antagonist amlodipine on nitrite , and interleukin-1beta (IL-1beta) formation and [iNOS] *induction* both in lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) treated rat aortic smooth muscle cells ( RASMC ) and in a rat model of endotoxemia . Positive_regulation NOS2 TNF 12153521 971457 Both LPS and *induce* the expression of the NF-kappaB dependent gene [inducible nitric oxide synthase (iNOS)] , which occurs subsequent to NF-kappaB activation . Positive_regulation NOS2 TNF 12384474 998794 In cultured adult rat CFbs , IL-1beta ( 5 ng/ml ) , but not interferon-gamma ( 10 ng/ml ) or ( 10 ng/ml ) , *induced* [inducible NO synthase (iNOS)] expression and NO production that was associated with an increase in caspase-3 activity and apoptotic cell death . Positive_regulation NOS2 TNF 12395315 1008627 In conclusion , [iNOS] expression in vivo is *dependent* on both and IFN-gamma . Positive_regulation NOS2 TNF 12395315 1008634 Although con A-induced liver injury depends on both TNFR1 and TNFR2 , *dependent* [iNOS] expression is mediated exclusively by TNFR1 and requires NF-kappaB activation . Positive_regulation NOS2 TNF 12509805 1038764 Here we report on the roles of nuclear factor-kappaB (NF-kappaB) and mitogen activated protein ( MAP ) kinases in *induced* [iNOS] expression in adult rat astroglia . Positive_regulation NOS2 TNF 12526099 1028241 The present study was undertaken to explore whether retinoids , which are known to have immunomodulatory actions , could attenuate *stimulated* [inducible nitric oxide synthase (iNOS)] expression in 3T3-L1 adipocytes . Positive_regulation NOS2 TNF 12526099 1028242 The inhibitory effect of RA on *induced* [iNOS] induction was reversible , completely recovered after 2 days , and was exerted through the inhibition of NF-kappaB activation . Positive_regulation NOS2 TNF 12594738 1060940 Although alone *induced* neither [iNOS] mRNA expression nor nitrite formation , it significantly potentiated the effect of LPS on both . Positive_regulation NOS2 TNF 12621554 1066422 Results showed that neither FK506 nor TP at lower concentration ( 10 microg/L ) alone affected *induced* COX-2 , [iNOS] expression and production of PGE2 , NO in synovial cells . Positive_regulation NOS2 TNF 12675973 1076740 These data suggest that after SCI , apoptosis induced by TNF-alpha may be mediated in part by NO via upregulation of [iNOS] , induced in *response* to . Positive_regulation NOS2 TNF 12754112 1090435 Investigation of downstream signaling pathways of apoptosis revealed that *induced* the expression of [iNOS] , but failed to stimulate the activity of caspase 3 . Positive_regulation NOS2 TNF 12839867 1108102 Endothelin-1 inhibits *induced* [iNOS] expression in 3T3-F442A adipocytes . Positive_regulation NOS2 TNF 12839867 1108103 In isolated adipocytes , *induces* the expression of the [inducible nitric oxide synthase (iNOS)] . Positive_regulation NOS2 TNF 12839867 1108104 The purpose of the present work was , in the 3T3-F442A adipocyte cell line , to characterise *induced* [iNOS] expression and to determine whether or not ET-1 could influence TNFalpha induced iNOS expression and NO production . Positive_regulation NOS2 TNF 12839867 1108105 *induced* [iNOS] expression requires nuclear factor kappaB activation , but does not necessitate the activation of the PI-3 kinase/Akt and P38-MAP kinase pathways . Positive_regulation NOS2 TNF 12839867 1108106 3 . ET-1 , but not ET-3 , inhibited the *induced* expression of [iNOS] protein and mRNA as well as nitrite production . Positive_regulation NOS2 TNF 12839867 1108107 6. Thus , these results confirm that adipocytes are a target for circulating ET-1 and demonstrate that the activation of the ETA receptor subtype can prevent *induced* [iNOS] expression . Positive_regulation NOS2 TNF 12858016 1110790 Earlier study showed that glucocorticoid induced receptor ( GITR ) , a new TNFR family , *activated* murine macrophages to express [inducible nitric oxide synthase (iNOS)] and to generate nitric oxide ( NO ) . Positive_regulation NOS2 TNF 12884305 1116567 *mediates* the induction of [nitric oxide synthase] in macrophages but not in neutrophils in experimental cutaneous leishmaniasis . Positive_regulation NOS2 TNF 14707269 1181026 *induces* [iNOS] and NO production in transformation-sensitive JB6 P+ , but not in transformation-resistant JB6 P- , mouse epidermal cells . Positive_regulation NOS2 TNF 14710909 1181386 Addition of RXM at a dose of 7.5 microg/ml to cell cultures caused reduction of [iNOS] mRNA expression , which was *enhanced* by stimulation in vitro . Positive_regulation NOS2 TNF 14985234 1250967 IL-Ibeta , , and LPS *increased* [inducible nitric oxide synthase (iNOS)] expression and cGMP production . Positive_regulation NOS2 TNF 14996411 1216225 The present investigation demonstrated that oligochitosan can significantly increase the activity of [inducible nitric oxide synthase (iNOS)] and *induce* the synthesis of nitric oxide ( NO ) and in macrophages . Positive_regulation NOS2 TNF 15019293 1220957 As and interferon-gamma (IFN-gamma) *contributed* crucially to the activation of [inducible NO synthase (iNOS)] gene transcription and to the differentiation of macrophages , we tested their roles in the induction of iMacs differentiation from bone marrow hematopoietic progenitor cells ( HPC ) of uncompromised mice . Positive_regulation NOS2 TNF 15019293 1220959 CD11b+Gr-1+ cells only derived in presence of [ GM-CSF + SCF + TNF-alpha ] or [ GM-CSF + SCF + IFN-gamma ] could express [iNOS] upon in vitro *stimulation* with [ IFN-gamma + ] or [ IFN-gamma + LPS ] known to boost iNOS expression in murine macrophages . Positive_regulation NOS2 TNF 15067740 1232059 [ Effect of Triptolide on *induced* activation of NF-kappaB and expression of COX-2 and [iNOS] in human rheumatoid arthritis synovial fibroblasts ] . Positive_regulation NOS2 TNF 15067740 1232062 To explore the effects of Triptolide ( TP ) on *induced* cell proliferation and expressions of cyclooxygenase-2 (COX-2) , [inducible nitric oxide synthase (iNOS)] and their inducing products PGE2 , NO in human rheumatoid arthritis synovial fibroblasts ( RASF ) . Positive_regulation NOS2 TNF 15067740 1232064 TP could significantly down-regulate *induced* COX-2 , [iNOS] expression and production of PGE2 , NO in human RASF , which is associated with the suppression of NF-kappaB activity . Positive_regulation NOS2 TNF 15176692 1254982 Since is a potent *activator* of macrophagic [inducible nitric oxide synthase (NOS)] , the aim of this study was to investigate whether TNF-alpha inhibition prevented hepatopulmonary syndrome and hyperdynamic circulatory state in rats with cirrhosis . Positive_regulation NOS2 TNF 15265685 1275396 In this study , we found that , but not receptor activator of nuclear factor kappa B ligand and interleukin 1 , *increased* the expression of [iNOS] both at the mRNA and protein levels . Positive_regulation NOS2 TNF 15618842 1348838 The production of large amounts of nitric oxide , consequent to endotoxin induced *mediated* upregulation of [inducible nitric oxide synthase (iNOS)] , has been suggested to be central to this phenomenon . Positive_regulation NOS2 TNF 15618842 1348839 Terlipressin has recently been shown in an animal model of cirrhosis to suppress endotoxin induced *mediated* upregulation of [iNOS] , thereby preventing overproduction of nitric oxide and restoring normal vascular tone . Positive_regulation NOS2 TNF 15851377 1399469 Neither FK506 nor TP at a lower concentration ( 10 ng/ml ) affected *induced* COX-2 and [iNOS] expressions or PGE subset2 and NO productions in synovial cells . Positive_regulation NOS2 TNF 15983205 1424814 The observed coincidence of IL-1beta and expression in the immune cells and the *induction* of [iNOS] and procaspase 3 mRNA expression in the beta-cells depicts a sequence of pathological changes leading to apoptotic beta-cell death in the IDDM rat . Positive_regulation NOS2 TNF 16033420 1436109 Amyloid-beta peptide enhances *induced* [iNOS] through neutral sphingomyelinase/ceramide pathway in oligodendrocytes . Positive_regulation NOS2 TNF 16033420 1436110 In order to study the roles of the amyloid-beta peptide in inducing oxidative stress damage in white matter of AD , we investigated the effects of amyloid-beta peptide 25-35 ( Abeta ) on proinflammatory cytokine *induced* [inducible nitric oxide synthase (iNOS)] in cultured oligodendrocytes ( OLGs ) . Positive_regulation NOS2 TNF 16033420 1436111 Although Abeta 25-35 by itself had little effect on iNOS mRNA , protein , and nitrite production , it enhanced *induced* [iNOS] expression and nitrite generation in OLGs . Positive_regulation NOS2 TNF 16033420 1436115 Cell permeable C2-ceramide enhanced *induced* [iNOS] expression and nitrite generation . Positive_regulation NOS2 TNF 16033420 1436119 These results suggest that neutral sphingomyelinase/ceramide pathway is required but may not be sufficient for [iNOS] expression *induced* by and the combination of TNF-alpha and Abeta . Positive_regulation NOS2 TNF 16055364 1488946 Although TNF-alpha is one of the iNOS-inducible factors , the [iNOS] up-regulation was not *regulated* by . Positive_regulation NOS2 TNF 16133968 1450286 , including other proinflammatory cytokines alone or in combination , *induces* [iNOS] expression and upregulates inflammatory responses . Positive_regulation NOS2 TNF 16133968 1450287 Although indomethacin significantly increased serum and nitrate/nitrite levels over the control value as early as 12 hr , [iNOS] expression was *detected* only after 4 days . Positive_regulation NOS2 TNF 16144552 1461265 We previously showed in NGF-responsive PC12 cells that and NGF synergistically *induce* the expression of the free-radical producing enzyme [inducible nitric oxide synthase (iNOS)] . Positive_regulation NOS2 TNF 16247220 1471553 Forced expression of SOCS1 significantly inhibited [iNOS] transcription *induced* by LPS , or interferon-gamma . Positive_regulation NOS2 TNF 16328964 1503644 Both and inosine *increased* nitrite accumulation and [nitric oxide synthase] activity . Positive_regulation NOS2 TNF 16421203 1554189 LPS mediated [iNOS] expression and apoptosis also were *inhibited* by siRNA mediated silencing of induction , indicating TNF induction both precedes and is necessary for subsequent regulation of iNOS expression . Positive_regulation NOS2 TNF 16613848 1568884 Using murine RAW 264.7 and primary bone marrow cells or osteoclasts formed from them by receptor activator of NF-kappaB ligand ( RANKL ) differentiation , we found that [inducible nitric-oxide synthase (iNOS)] expression and NO generation were *stimulated* by interferon (IFN)-gamma or lipopolysaccharide , but not by interleukin-1 or . Positive_regulation NOS2 TNF 16754782 1599076 The cell-permeable cGMP analog 8-Br-cGMP , xanthine based KMUP-1 and KMUP-3 , and the phosphodiesterase 5 inhibitor zaprinast all inhibited *induced* increases of [iNOS] expression and NO levels and reversed TNF-alpha induced decreases of sGCalpha1 , sGCbeta1 , and PKG expression . Positive_regulation NOS2 TNF 16754782 1599097 In conclusion , xanthine based KMUP-1 and KMUP-3 inhibit *induced* expression of [iNOS] in TSMCs , involving the sGC/cGMP/PKG expression pathway but without the involvement of COX-2 . Positive_regulation NOS2 TNF 16827641 1586616 The *role* of in mediating pathophysiological activity of inducible [nitric oxide synthase] during transplant vasculopathy remains contentious . Positive_regulation NOS2 TNF 16873093 1593282 On the other hand , BMK strongly inhibited interleukin-1beta (IL-1beta)- and *induced* [Nitricoxide (NO) synthase] expression with little effect on constitutive NO synthase expression . Positive_regulation NOS2 TNF 16940413 1639230 It suppressed the transcription of NF-kappaB downstream gene products including cyclooxygenase-2 and inducible [nitric-oxide synthase] *induced* by or lipopolysaccharide in macrophages and hepatocarcinoma cells . Positive_regulation NOS2 TNF 17035338 1674557 Taken together , our data suggest that the produced in response to IFN-gamma is *required* for [iNOS] induction by activating NF-kappaB transcription factor . Positive_regulation NOS2 TNF 17070777 1649817 Stimulation of human bronchial EC line HS-24 by *caused* an increased expression of [inducible nitric oxide synthase (iNOS)] . Positive_regulation NOS2 TNF 17091492 1667556 *induced* [iNOS] expression increased by prostaglandin E2 in rat primary astrocytes via EP2 evoked cAMP/PKA and intracellular calcium signaling . Positive_regulation NOS2 TNF 17438334 1742841 IL-22 did not stabilize *induced* [iNOS] mRNA . Positive_regulation NOS2 TNF 17604001 1768465 We found that , in glomerular podocytes , *induction* of monocyte chemoattractant protein 1 ( MCP-1 ) and [inducible nitric oxide synthase (iNOS)] by was abrogated by K-7174 . Positive_regulation NOS2 TNF 17604001 1768467 Furthermore , K-7174 elicited UPR abrogated *induction* of MCP-1 and [iNOS] not only by but also by medium conditioned by activated macrophages . Positive_regulation NOS2 TNF 17851925 1910971 *Induction* of inducible [nitric oxide synthase] and apoptosis by LPS and in nasal microvascular endothelial cells . Positive_regulation NOS2 TNF 17851925 1910973 The expression of [iNOS] *induced* by both the LPS and was investigated by fluorescent immunohistochemistry , using confocal laser microscopy . Positive_regulation NOS2 TNF 17851925 1910975 The fluorescent immunohistochemistory study demonstrated that LPS and *induced* the expression of [iNOS] in HNMECs . Positive_regulation NOS2 TNF 17851925 1910976 remarkably *augmented* the expression of [iNOS] in HNMECs in comparison to stimulation by either LPS or TNF-alpha alone . Positive_regulation NOS2 TNF 18054434 1852583 *Induction* of [inducible NOS] by in combination with lipopolysaccharide (LPS) dramatically attenuated SULT2B1a expression ; Positive_regulation NOS2 TNF 18242889 1864997 However , aminoguanidine ( AG ) , a selective *inhibitor* of [inducible nitric oxide synthase (iNOS)] , and pentoxifylline (PTX) , an inhibitor of synthesis , had no effect on LPS induced upregulation of HO-1 in fetal liver . Positive_regulation NOS2 TNF 18275839 1937995 In Caco-2 cells , Hex ( 2.5-20 microM ) inhibited *induced* NF-kappaB activation ( IkappaB phosphorylation and degradation , p50 and RelA nuclear translocation , and NF-kappaB-DNA binding ) , inducible [nitric oxide synthase] expression , and cell oxidant increase . Positive_regulation NOS2 TNF 18295395 1896672 Chondroitin sulfate extracted from the Styela clava tunic suppresses *induced* expression of inflammatory factors , VCAM-1 and [iNOS] by blocking Akt/NF-kappaB signal in JB6 cells . Positive_regulation NOS2 TNF 18295395 1896685 Our results showed that CS inhibited *induced* NF-kappaB activation and subsequent vascular cell adhesion molecule 1 and inducible [nitric oxide synthase] expressions by blocking Akt signals in JB6 cells . Positive_regulation NOS2 TNF 18369347 1912828 This effect seemed to be associated with the *induced* expression of [iNOS] . Positive_regulation NOS2 TNF 18369347 1912830 The results showed that *induced* [iNOS] expression and release of NO after 24-h treatment of differentiated 3T3-L1 adipocytes . Positive_regulation NOS2 TNF 18369347 1912833 In addition , pretreatment with protein tyrosine kinase (PTK) inhibitors , genistein and AG-1288 , prevented *induced* [iNOS] expression and subsequent resistin downregulation . Positive_regulation NOS2 TNF 18755151 1975279 IFNgamma and dramatically *induced* the expression of [inducible nitric oxide synthase (iNOS)] by BMSCs in culture , and BMSCs generated from iNOS knockout mice did not induce apoptosis of lymphoma cells in the presence of IFNgamma and TNF . Positive_regulation NOS2 TNF 18957328 2014827 Interleukin-1beta (IL-1beta) and *induced* [iNOS] gene expression and NO production , although these actions were inhibited by L-NG-monomethylarginine ( L-NMMA ) and decreased alkaline phosphatase ( ALPase ) activity . Positive_regulation NOS2 TNF 19164562 2032457 The presence of Gr-1 ( + ) neutrophils and elevated expression in colon were *required* for increased [iNOS] expression and cancer , whereas interleukin-10 (IL-10) down-regulated TNF-alpha and iNOS expression and suppressed cancer . Positive_regulation NOS2 TNF 19188055 2049373 Western blot analysis of mouse macrophage cell line RAW 264.7 activated with lipopolysaccharide showed that bisdemethoxycurcumin inhibited inducible nitric oxide synthase (iNOS) production significantly but had no effect on tumor necrosis factor-alpha (TNF-alpha) production , whereas curcumin showed stronger suppression of [iNOS] protein production and *inhibited* protein production significantly . Positive_regulation NOS2 TNF 19383900 2066109 Furthermore , SW480 cells stably transformed with wild-type adenomatous polyposis coli showed decreased beta-catenin protein and increased *induced* p65 NF-kappaB binding as well as [iNOS] and Traf1 expression . Positive_regulation NOS2 TNF 19776225 2232019 In contrast , overexpression of 11 beta-HSD1 further augmented *induced* [iNOS] , IL-6 , and MCP-1 expression . Positive_regulation NOS2 TNF 19819972 2154507 Suppression of *induced* [iNOS] expression using short hairpin RNA significantly reduced TNF-alpha induced lipolysis . Positive_regulation NOS2 TNF 19967660 2174479 In diabetes , whether peroxynitrite ( ONOO ( - ) ) , generated from [inducible nitric oxide synthase (iNOS)] *induced* by , plays a primary role in the pathogenesis of glomerular lesion is not yet fully known . Positive_regulation NOS2 TNF 20135642 2235875 Integrin linked kinase is involved in induced *inducible* [nitric-oxide synthase] expression in myoblasts . Positive_regulation NOS2 TNF 20135642 2235882 stimulation *caused* [iNOS] expression and NO production in myoblasts ( G7 cells ) . Positive_regulation NOS2 TNF 20135642 2235897 Our results suggest that *increased* [iNOS] expression and NO production in myoblasts via the ILK/Akt/mTOR and NF-kappaB signaling pathway . Positive_regulation NOS2 TNF 20199198 2216433 Hypoxia is associated with an increase in the generation of several proinflammatory cytokines and other inflammation mediators , such as , IL-1-beta , IL-6 , IL-8 , chemokines ( monocyte chemoattractant protein-1 , CC-chemokine receptor 2 , macrophage inflammatory protein-1alpha , intercellular adhesion molecule-1 ) , acute-phase protein gene expressions , COX-2 gene transcription , *induction* of [iNOS] , and reactive oxygen species . Positive_regulation NOS2 TNF 20489729 2327429 induced *activation* of p38 MAPK and the production of inducible [nitric oxide synthase] were suppressed in ASK1-deficient Müller glial cells . Positive_regulation NOS2 TNF 20541824 2301946 The expression of [iNOS] and the promoting apoptosis gene Bax and Fas were significantly *up-regulated* by the induction of IL-1beta and . Positive_regulation NOS2 TNF 20675566 2322640 This improvement is due to the role of resveratrol in inhibiting induced NF-?B activation , therefore subsequently *inhibiting* the expression and activation of NAD(P)H oxidase and [iNOS] as well as increasing eNOS expression in type 2 diabetes . Positive_regulation NOS2 TNF 20678226 2305647 This activation of IDO by direct application of LPS was preceded by synthesis and secretion of and IL-6 protein and *activation* of [iNOS] while IFN gamma expression was undetectable . Positive_regulation NOS2 TNF 20805415 2324605 Enhanced Rac activation and phagocytosis following IFN-? priming were dependent on NO production via inducible NO synthase and activation of protein kinase G. Notably , endogenous production of in response to IFN-? priming was critically *required* for [inducible NO synthase] upregulation , NO production , Rac activation , and enhanced phagocytosis . Positive_regulation NOS2 TNF 20884819 2357070 Positive immunolabelings for interleukin-6 , *inducible* [nitric oxide synthase] , and dimeric copper- and zinc containing superoxide dismutase were observed mainly in the inflammatory cells in the lesions ; Positive_regulation NOS2 TNF 21567079 2441238 Newcastle disease virus ( NDV ) is an interesting agent for activating innate immune activity in macrophages including secretion of and IFN-a , upregulation of TRAIL and *activation* of NF-?B and [iNOS] . Positive_regulation NOS2 TNF 21637955 2531997 Aldose reductase regulates induced *inducible* [nitric oxide synthase] expression in human mesangial cells . Positive_regulation NOS2 TNF 21637955 2532004 Here , we report our finding that AR regulates *induced* ( TNF-a induced ) [iNOS] expression in human mesangial cells ( HMC ) via nuclear factor ?B ( NF?B ) signal pathway . Positive_regulation NOS2 TNF 21637955 2532005 The *induced* [iNOS] expression in HMC with different level of AR was measured by Real-time PCR and Western blot . Positive_regulation NOS2 TNF 21637955 2532007 In cultured HMC , *induces* the expression of [iNOS] , which is attenuated by knockdown AR with siRNA . Positive_regulation NOS2 TNF 21637955 2532008 Taken together , these data demonstrate the role of AR in regulating [iNOS] expression *induced* by in cultured HMC , indicating the novel function of AR in glomerulonephritis besides glucose metabolism . Positive_regulation NOS2 TNF 22000995 2526255 Pentoxifylline markedly reduced the expression of Icam1 and [iNos] *induced* by in vitro in AR42J cells . Positive_regulation NOS2 TNF 22000995 2526261 Oxidative stress significantly contributes to the *induced* up-regulation of Icam and [iNos] in AR42J cells . Positive_regulation NOS2 TNF 22005300 2503243 Surprisingly , MDL-1 induced NO and production *required* eNOS but not [iNOS] . Positive_regulation NOS2 TNF 22065579 2534132 Phorbol ester- and *dependent* activation of the ERK regulated transcription factors Elk1 and NF-?B and expression of the [iNOS] gene were suppressed by hBVR siRNA ; Positive_regulation NOS2 TNF 22230399 2519484 KMUP-1 inhibited *induced* [iNOS] and U46619 induced PDE-5A and phospho-p38 MAPK in normoxia , confirming its anti-proinflammatory action . Positive_regulation NOS2 TNF 22526394 2595921 also *increased* the production of [inducible nitric oxide synthase (iNOS)] , nitric oxide ( NO ) , and intercellular adhesion molecule 1 ( ICAM-1 ) through activation of p38 mitogen activated protein kinase (MAPK) from HT-29 cells . Positive_regulation NOS2 TNF 22570350 2614209 Critical role of *induced* macrophage VEGF and [iNOS] production in the experimental corneal neovascularization . Positive_regulation NOS2 TNF 22570350 2614211 Moreover , *enhanced* VEGF and [iNOS] expression by peritoneal macrophage from WT , but not KO mice . Positive_regulation NOS2 TNF 22704420 2616008 FYN significantly inhibited *induced* expression of [iNOS] and COX-2 compared with the control group in A549 cells ( P < 0.01 , P < 0.01 ) . Positive_regulation NOS2 TNF 22704420 2616013 These results suggest that FYN inhibits [iNOS] and COX-2 activation *induced* by , therefore , it is expected to develop a new strategy to treat lung cancer . Positive_regulation NOS2 TNF 22815072 2676743 significantly *increased* NO generation and [iNOS] expression . Positive_regulation NOS2 TNF 22847916 2682366 and IFNG *stimulated* the relative steady-state amounts of inducible nitric oxide synthase (iNOS) mRNA and [iNOS] protein expression ( P < 0.05 ) , whereas P4 inhibited relative steady-state amounts of iNOS mRNA and iNOS protein expression ( P < 0.05 ) . Positive_regulation NOS2 TNF 22863952 2677304 Therefore , *induced* [iNOS] activates a p53 dependent pathway of IEC apoptosis in CUC . Positive_regulation NOS2 TNF 23302986 2733094 ROS scavenger administration before isoflurane abolished the isoflurane preconditioning effect as well as isoflurane induced inhibition of phosphorylation of inhibitory ?Ba , NF?B p65 , [iNOS] *activation* , and mRNA expression of and IL-6 in acute LPS challenged lungs . Positive_regulation NOS2 TNF 23527096 2761982 In addition , NaHS treatment prevented the increase of nitric oxide , Intercellular Adhesion Molecule 1 ( ICAM-1 ) and interleukin (IL)-6 production and inducible [nitric oxide synthase] activation *induced* by . Positive_regulation NOS2 TNF 23717114 2714410 Air dried PG leaf extract inhibited *induced* NF-?B transcription activity and NF-?B dependent cyclooxygenase (COX)-2 and [inducible nitric oxide synthase (iNOS)] gene expression more efficiently than the steamed extract . Positive_regulation NOS2 TNF 23717114 2714411 Furthermore , the ginsenosides Rd and Km inhibited the *induced* expression levels of the COX-2 and [iNOS] gene in HepG2 cells . Positive_regulation NOS2 TNF 23726836 2819757 Tetramethylpyrazine attenuates *induced* [iNOS] expression in human endothelial cells : Involvement of Syk mediated activation of PI3K-IKK-I?B signaling pathways . Positive_regulation NOS2 TNF 23726836 2819758 We explored the effect of tetramethylpyrazine ( TMP ) , a compound derived from chuanxiong , on *induced* [iNOS] in human umbilical vein endothelial cells ( HUVECs ) and explored the signal pathways involved by using RT-PCR and Western blot . Positive_regulation NOS2 TNF 23726836 2819759 TMP suppressed *induced* expression of [iNOS] by inhibiting I?B kinase ( IKK ) phosphorylation , I?B degradation and nuclear factor ?B ( NF-?B ) nuclear translocation , which were required for NO gene transcription . Positive_regulation NOS2 TNF 23815760 2870679 Compounds 1-6 also exhibited inhibition of *induced* expression of [iNOS] and ICAM-1 mRNA and dose dependent inhibition of iNOS promoter activity , with IC50 values ranging from 3.3 to 5.0 µM . Positive_regulation NOS2 TNF 24039983 2842420 Paraquat poisoning induces *dependent* [iNOS/NO] mediated hyporesponsiveness of the aorta to vasoconstrictors in rats . Positive_regulation NOS2 TNF 24204674 2864605 In conclusion , metformin inhibits the *induced* inflammatory signaling and NF-?B mediated [iNOS] expression in lung tissue of obese mice . Positive_regulation NOS2 TNF 24507356 2914247 The results showed that the treatment of macrophages with CS3 could not only increase the nitric oxide ( NO ) release and the cytokines , IL-6 and IL-1ß production significantly , but also *enhance* the [inducible NOS (iNOS)] expression , NF-?Bp65 nuclear translocation , Erk1/2 and SAPK/JNK phosphorylation . Positive_regulation NOS2 TNF 24777714 2950244 Furthermore , expressions of tumor necrosis factor (TNF)-a and monocyte chemoattractant protein (MCP)-1 messenger ( m ) RNA in U87 and C6 cells were detected by an RT-PCR , and and MCP-1 *induced* [iNOS] protein expression in time- and concentration dependent manners . Positive_regulation NOS2 TNF 24905701 2952089 Furthermore , HMGB1 and IL-1ß and/or a ( but not HMGI/Y ) also significantly *induced* inducible [nitric oxide synthase] , NO , and interleukin (IL)-8 production in human cartilage and chondrocytes . Positive_regulation NOS2 TNF 7504484 237422 Nitric oxide and [nitric oxide synthase] mRNA *induction* in mouse islet cells by interferon-gamma plus . Positive_regulation NOS2 TNF 7504484 237428 Here we show that interferon-gamma (IFN-gamma) and synergistically *induced* NO production and [inducible NO synthase (iNOS)] mRNA expression in mouse islet cells . Positive_regulation NOS2 TNF 7506700 244442 These findings suggest that interferon gamma directly *induces* the expression of the inducible [nitric oxide synthase] gene , whereas and interleukin-1 beta induce it , at least in part , via the induction of intermediary protein ( s ) , and that transforming growth factor-beta 1 inhibits cytokine induced nitric oxide production by blocking the posttranscriptional synthesis of inducible nitric oxide synthase . Positive_regulation NOS2 TNF 7509010 240173 Dexamethasone inhibits [nitric oxide synthase] mRNA *induction* by interleukin-1 alpha and in vascular smooth muscle cells . Positive_regulation NOS2 TNF 7513301 253697 In this study , we determine whether produced by activated bone marrow derived macrophages ( BMM ) is *involved* in the induction of the [inducible NO synthase] gene ( mac-NOS ) for NO-dependent amebicidal activity . Positive_regulation NOS2 TNF 7513694 253780 The *role* of endogenous and interferon-beta (IFN-beta) in lipopolysaccharide (LPS) induced activation of the [inducible nitric-oxide synthase (i-NOS)] gene was investigated . Positive_regulation NOS2 TNF 7513694 253784 These data thus suggest that endogenous IFN-beta , but not , produced by LPS stimulated J774 cells specifically *contributes* , probably in an auto/paracrine fashion , to the activation of the [i-NOS] gene expression by LPS . Positive_regulation NOS2 TNF 7514535 254047 However , [iNOS] synthesis *requires* the presence of both and IFN-gamma , while VCAM-1 can be induced by either cytokine alone . Positive_regulation NOS2 TNF 7529496 291453 The inflammatory mediators interleukin-1 beta (IL-1 beta) , and the bacterial cell wall fragment endotoxin , *induced* both [nitric oxide synthase] activity and stromelysin and collagenase activity in whole cell preparations and in conditioned media from explants of bovine and human cartilage . Positive_regulation NOS2 TNF 7530365 291622 Thus , endogenous is not *required* for LPS induced acute phase hypotension or [iNOS] II activity . Positive_regulation NOS2 TNF 7530759 291722 Although induce iNOS expression and inhibit insulin secretion by intact islets , this combination does not *induce* the expression of [iNOS] by beta or alpha cells purified by fluorescence activated cell sorting ( Facs ) . Positive_regulation NOS2 TNF 7530759 291732 Immunohistochemical localization of iNOS and insulin confirm that *induce* the expression of [iNOS] by islet beta cells , and that a small percentage of noninsulin containing cells also express iNOS . Positive_regulation NOS2 TNF 7536858 300318 PDTC ( 100 microM ) was able to inhibit the [iNOS] activity *induced* by LPS and independently ( 56.8 and 49.9 % inhibition , respectively ) , and in combination ( 79.1 % inhibition ) . Positive_regulation NOS2 TNF 7536858 300319 PDTC ( 1 to 100 microM ) inhibited LPS + *induced* NO synthesis and [iNOS] mRNA expression in a concentration dependent fashion ( 69 to 86 % inhibition of NO synthesis and 50 to 100 % inhibition of mRNA expression ) . Positive_regulation NOS2 TNF 7543491 314296 or IFN-gamma *increased* [iNOS] expression . Positive_regulation NOS2 TNF 7573346 324958 Thus , interleukin-1 alpha and inducible [nitric oxide synthase] were *induced* mostly in the cells accumulated around the beads and also in some bronchiolar epithelial cells during the early phase ( 1 to 3 days ) , whereas was induced in the cells around the beads at the later resolution phase ( 3 to 7 days ) . Positive_regulation NOS2 TNF 7680009 211338 Interferon gamma (IFN gamma) and markedly *increased* [iNOS] mRNA levels in time- and dose dependent manners . Positive_regulation NOS2 TNF 7680009 211342 These results suggest that IFN gamma directly *induces* the expression of the [iNOS] gene whereas mainly induces it via the induction of an intermediary protein in cultured VSMC . Positive_regulation NOS2 TNF 8549863 346493 Used alone or in combination , and IFN significantly *enhanced* the activity of inducible [nitric oxide synthase] as determined by measuring the conversion of 14C labeled arginine to 14C labeled citrulline and nitric oxide . Positive_regulation NOS2 TNF 8609750 352849 Nitric oxide ( NO ) exerts a negative inotropic effect on the myocardium and is produced by NO-synthase , an inducible form of which ( [iNOS] ) is *stimulated* by tumour necrosis factor ( ) . Positive_regulation NOS2 TNF 8614565 342832 Using reverse transcriptase-polymerase chain reaction ( RT-PCR ) and Southern blot analysis , we also found that produce an *increase* of [inducible NO synthase (iNOS)] mRNA expression . Positive_regulation NOS2 TNF 8662883 367479 In contrast , sepiapterin , which provides BH4 through the pterin salvage pathway , strongly potentiated *induced* [iNOS] expression and abrogated the inhibitory effect of DAHP . Positive_regulation NOS2 TNF 8680718 343247 In marked contrast the presence of *had* no effect on IL-1 alpha/IFN-gamma induced [iNOS] mRNA expression by HT-29 cells . Positive_regulation NOS2 TNF 8737749 376970 Here we show that in cultured bovine chondrocytes and explants of human osteoarthritic cartilage both [nitric oxide synthase] and cyclooxygenase activities were *induced* by the inflammatory mediators , lipopolysaccharide , and interleukin-1 beta or . Positive_regulation NOS2 TNF 8746212 344050 Experimental and clinical evidence suggests that *induces* the expression of vascular [nitric oxide (NO) synthase] within hours and that NO released from smooth muscle cells could be involved in the pathogenesis of septic shock . Positive_regulation NOS2 TNF 8779862 379922 *Roles* of IL-1 and in endotoxin induced activation of [nitric oxide synthase] in cultured rat brain cells . Positive_regulation NOS2 TNF 8830655 385493 and IL-1beta synergistically *stimulate* [iNOS] transcription in rat glomerular mesangial cells . Positive_regulation NOS2 TNF 8861703 388540 These data suggest that vasodilation by LPS is mainly due to nitric oxide predominantly synthesized by an inducible [nitric oxide synthase] , proximally *induced* by . Positive_regulation NOS2 TNF 8903396 393902 Thus , the present study suggests that NO and TNF-alpha released from LPS pretreated Kupffer cells directly inhibit the hepatocyte mitochondrial function in the early phase , and then NO synthesized by *induced* hepatocyte [iNOS] causes lethal hepatocyte injury , characterized by diminished mitochondrial energization and membrane barrier function in the late phase . Positive_regulation NOS2 TNF 8917029 395974 The hypothesis that in humans , *induces* vasodilation and shock through activation of inducible [nitric-oxide synthase] and subsequent formation of excessive quantities of nitric oxide is not substantiated by our results . Positive_regulation NOS2 TNF 9193655 438005 Although the precise mechanism requires further investigation , our results indicate that ADP-ribosylation is a crucial step restricted to the signalling pathway which leads to [iNOS] mRNA induction , as well as and MHC class II *induction* during macrophage activation . Positive_regulation NOS2 TNF 9199204 438683 In an attempt to modulate *induced* expression of [iNOS] in MCECs , we designed a double-strand hairpin ( hp ) oligonucleotide carrying the NF-kappaB motif . Positive_regulation NOS2 TNF 9199204 438687 The present study confirms the role of transcription factor NF-kappaB in [iNOS] expression *induced* by in MCECs . Positive_regulation NOS2 TNF 9215702 441813 The isoform of the [nitric oxide synthase] *induced* in human neuroblastoma cells by treatment was identified enzymatically as isoform II by Western blotting and by the polymerase chain reaction . Positive_regulation NOS2 TNF 9231726 444924 The inhibitory effect of ET on *stimulated* [iNOS] expression appears to be mediated by ET ( B ) receptors , because ( 1 ) both ET-1 and ET-3 inhibited the effects of TNF-alpha/IL-1beta on iNOS expression and nitrite accumulation , ( 2 ) a selective ET ( B ) receptor agonist , Suc- [ Glu ( 9 ) , Ala ( 11,15 ) ] -ET-1 ( 8-21 ) ( IRL1620 ) , decreased the effects of TNF-alpha/IL-1beta , and ( 3 ) a selective ET ( B ) receptor antagonist , N-cis-2,6-dimethylpiperidinocarbonyl-L-gamma-methylleucyl-D- 1-methoxycarbonyltryptophanyl-D-norleucine , abolished the inhibitory effects of ETs and IRL1620 . Positive_regulation NOS2 TNF 9278945 450998 IFN gamma/ LPS induced iNOS mRNA levels were effected less than were [iNOS] mRNA levels *induced* by IFN gamma/IL-2 or IFN gamma/ . Positive_regulation NOS2 TNF 9281616 451514 Interestingly , antioxidants such as N-acetylcysteine (NAC) , ascorbic acid , or alpha-tocopherol fail to inhibit *induced* increase in [iNOS] protein . Positive_regulation NOS2 TNF 9315292 455765 and interleukin-1 beta are *involved* in the induction of [iNOS] gene as well as the immune system . Positive_regulation NOS2 TNF 9347218 460582 and IL-6 may be produced in heart failure and may *induce* [inducible NO synthase] , resulting in NO production , which acts as a negative inotrope . Positive_regulation NOS2 TNF 9353295 461426 Treatment of mouse astrocyte cultures with combined interleukin (IL)-1alpha and tumor necrosis factor (TNF)-alpha induced expression of inducible nitric-oxide synthase (iNOS) , resulting in sustained release of large amounts of nitric oxide , whereas and IL-1alpha individually were unable to *induce* [iNOS] expression in astrocytes . Positive_regulation NOS2 TNF 9353295 461428 The p38 ( MAPK ) pathway is specifically involved in *induced* [iNOS] expression , since iNOS protein and nitric oxide release in the presence of a specific inhibitor of p38 ( MAPK ) , 4- ( 4-fluorophenyl ) -2-2- ( 4-hydroxyphenyl ) -5- ( 4-pyridyl ) -imidazole ( FHPI ) , were dramatically diminished . Positive_regulation NOS2 TNF 9353295 461432 These data suggest that *induced* [iNOS] expression depends on a yet undetermined second pathway in addition to p38 ( MAPK ) . Positive_regulation NOS2 TNF 9369379 464026 A reverse transcription-polymerase chain reaction ( RT-PCR ) assay revealed that *caused* a concentration- and time dependent expression of [inducible NO synthase] in brown adipocytes . Positive_regulation NOS2 TNF 9400371 469229 Forskolin , interleukin (IL)-6 , , or interferon (IFN)-gamma *enhanced* the LPS induced [iNOS] expression . Positive_regulation NOS2 TNF 9405166 469726 However , this low does not suffice to *induce* [iNOS] - documented by reverse transcriptase polymerase chain reaction - or enhance nitrite concentrations in the cell culture supernatants as a measure of cellular NO production , neither in the presence nor absence of dexamethasone ( 0.1 micro M ) . Positive_regulation NOS2 TNF 9472897 486317 alone or in combination with endotoxin or other cytokines can *cause* expression of [inducible nitric oxide (NO) synthase] . Positive_regulation NOS2 TNF 9472897 486318 The present study indicates that *causes* cerebral vasodilatation and expression of [inducible NO synthase] in perivascular and arachnoid cells . Positive_regulation NOS2 TNF 9473143 476315 These results suggest that the increase in [inducible NO synthase] expression by endothelin was *due* to the elevated production via protein kinase C . Positive_regulation NOS2 TNF 9551998 499170 *Induction* of [inducible nitric-oxide synthase (iNOS)] , IL-1beta , and IL-8 genes by IL-1beta , , or PMA was blocked in Ad5 IkappaB infected cells but not in Ad5 LacZ controls as assayed by RT-PCR and ELISA . Positive_regulation NOS2 TNF 9650577 515399 Treatment of the cells with the A2A receptor agonist CGS 21680 inhibited both NO production and [iNOS] expression *induced* by stimulation with either LPS/IFN-gamma or , whereas the A1 and A3 receptor agonists , CPA and Cl-IB-MECA , respectively , did not have significant inhibitory effects . Positive_regulation NOS2 TNF 9693272 523366 Single stimulation of smooth muscle cells with either neopterin or *caused* inducible [nitric oxide synthase] gene expression and nitric oxide production . Positive_regulation NOS2 TNF 9761373 536762 Production of gamma-interferon ( IFN-gamma ) and in Trypanosoma cruzi infected mice *results* in the activation of [inducible nitric oxide synthase (iNOS)] and in elevated nitric oxide ( NO ) synthesis , which is important for the macrophage trypanocidal activity . Positive_regulation NOS2 TNF 9794913 543196 Hepatocellular , but not bile duct , injury occurs during experimental pancreatitis that is associated with hepatic TNF- , IL-1beta , and [iNOS] mRNA gene *induction* , as well as protein and nitrite production . Positive_regulation NOS2 TNF 9834372 479674 *regulates* inducible [nitric oxide synthase] gene expression in the portal hypertensive gastric mucosa of the rat . Positive_regulation NOS2 TNF 9875639 557217 In transformed hepatic stellate cells , and interferon-gamma have a crucial role in nitric oxide production , and extracellular L-arginine transport and inducible [nitric oxide synthase] expression are *regulated* in a differential cytokine-specific manner . Positive_regulation NOS2 TNF 9918806 559198 Potential role of the JNK/SAPK signal transduction pathway in the *induction* of [iNOS] by . Positive_regulation NOS2 TNFSF10 17540725 1778504 In addition , GAPDH small interfering RNA partially prevented the apoptotic effect of TRAIL , although *induced* [nitric oxide synthase] stimulation and production of nitric oxide were not attenuated . Positive_regulation NOS2 TNFSF10 21567079 2441239 Newcastle disease virus ( NDV ) is an interesting agent for activating innate immune activity in macrophages including secretion of TNF-a and IFN-a , upregulation of and *activation* of NF-?B and [iNOS] . Positive_regulation NOS3 ADRB2 12617769 1065731 Isoprenaline increases [eNOS] activity of HUVEC , this is *mediated* by and associated with an increase of eNOS serine phosphorylation level . Positive_regulation NOS3 ALDH2 22155639 2536596 Here we show that in human aortic endothelial cells ( HAECs ) , rapid activation of mitochondrial mediates ethanol *induced* [eNOS] activation by preventing reactive oxygen species ( ROS ) accumulation . Positive_regulation NOS3 ANGPT1 12759249 1091071 In summary , our results demonstrate for the first time that endothelial derived NO is required for Ang1 induced angiogenesis , and that the PI3-kinase signaling mediates the activation of [eNOS] and NO release in *response* to . Positive_regulation NOS3 ANGPT1 16380295 1539808 Combined gene transfer of both and ad-VEGF165 significantly *increased* cavernous angiogenesis , [eNOS] phosphorylation , and cGMP expression compared with that in the groups treated with either therapy alone . Positive_regulation NOS3 ANGPT1 18078386 1903342 in contrast , *increased* [eNOS] expression and augmented nitrate wound content and VEGFR-2 immunostaining and protein expression . Positive_regulation NOS3 ANGPT1 18556567 1946041 These alterations led to a significant impairment of *induced* Akt and [eNOS] phosphorylation , along with a remarkable impairment of Ang-1 induced endothelial cell migration and endothelial cell spheroid sprouting . Positive_regulation NOS3 ANGPT1 19564638 2142530 In contrast to VEGF stimulation , *causes* a marked protein kinase C ( PKC ) -dependent increase in phosphorylation of [eNOS] on the inhibitory Thr ( 497 ) . Positive_regulation NOS3 ARSA 18077625 1868184 Therefore , <5-ASA> prevents irradiation *induced* inflammatory processes as well as expression of tumor necrosis factor alpha , monocyte chemotactic protein-1 , inducible [nitric-oxide synthase] , and macrophage infiltration . Positive_regulation NOS3 BLVRA 25206501 2886918 We hypothesize that dependent *inducible* [nitric oxide synthase] regulation strongly contributes to the cognitive improvement observed following atorvastatin treatment . Positive_regulation NOS3 CAPN8 10835326 699166 *Role* of in hypoxic inhibition of [nitric oxide synthase] activity in pulmonary endothelial cells . Positive_regulation NOS3 CAPN8 16100081 1466462 In this study , we evaluated the *role* of in CSE induced decrease in [eNOS] gene expression . Positive_regulation NOS3 CAPN8 16100081 1466581 These results indicate that CSE induced inhibition of [eNOS] expression in PAEC is *caused* by inhibition due to an increase in calpastatin protein content . Positive_regulation NOS3 CAPN8 18624772 2179451 Activation of protease by oxidized and glycated LDL *increases* the degradation of endothelial [nitric oxide synthase] . Positive_regulation NOS3 CAPN8 18682401 1973392 We propose that the protective effect exerted by HSP90 on [eNOS] degradation *mediated* by represents a novel and critical mechanism that assures the reversibility of the intracellular trafficking and activation of the synthase . Positive_regulation NOS3 EDN2 10770961 686094 Dysfunctional renal [nitric oxide synthase] as a determinant of salt-sensitive hypertension : mechanisms of renal artery endothelial dysfunction and *role* of for vascular hypertrophy and Glomerulosclerosis . Positive_regulation NOS3 EDN2 12623978 1066533 inhibits NPR-A and *stimulates* [eNOS] gene expression in rat IMCD cells . Positive_regulation NOS3 EDN2 9473143 476307 *enhances* lipopolysaccharide induced expression of inducible [nitric oxide synthase] in rat glial cells . Positive_regulation NOS3 EPHB2 10899167 730658 Taken together , our results suggest that bradykinin induced activation of *leads* to [eNOS] phosphorylation and enzyme inhibition , a process influenced by the reversible associations of members of the MAP kinase pathway with eNOS . Positive_regulation NOS3 EPHB2 12372406 996387 Porphyromonas gingivalis lipopolysaccharide interferes with salivary mucin synthesis through inducible [nitric oxide synthase] *activation* by and p38 kinase . Positive_regulation NOS3 EPHB2 12937820 1132997 E ( 2 ) inhibited the expression of , phosphorylated ERK and *induced* the [eNOS] expression . Positive_regulation NOS3 EPHB2 14586499 1165267 Our results show that C-peptide increases NO production by increasing eNOS protein contents through *dependent* up-regulation of [eNOS] gene transcription . Positive_regulation NOS3 EPHB2 16164642 1456359 and VEGF stimulated eNOS phosphorylation on Ser1177 was prevented by PD098059 , an upstream inhibitor of ERK , demonstrating that was *involved* in VEGF regulation of [eNOS] . Positive_regulation NOS3 EPHB2 16455784 1547990 We report that pregnancy adaptation of eNOS activation includes the reduced sensitivity to *mediated* attenuation of eNOS activity and enhanced stimulation of [eNOS] activity through a wortmannin-sensitive , LY294002-insensitive , Akt independent mechanism . Positive_regulation NOS3 EPHB2 16877565 1638831 However , inhibitors of Raf-1 and MEK or a dominant negative mutant *blocked* FKN induced ERK , but not Akt and [eNOS] , phosphorylation . Positive_regulation NOS3 EPHB2 17714736 1789413 Meanwhile , PCNA expression and activation were augmented with decreased lung tissue CO and HO-1 protein production but *increased* lung tissue NO production and [eNOS] expression . Positive_regulation NOS3 EPHB2 19474186 2107590 In conclusion , this study suggests that sildenafil has antiapoptotic effects in experimental IR renal injury via phosphorylation , *induction* of iNOS and [eNOS] production , and a decrease in the Bax/Bcl-2 ratio . Positive_regulation NOS3 FAS 14967838 1220248 signaling *induces* Akt activation and upregulation of endothelial [nitric oxide synthase] expression . Positive_regulation NOS3 FAS 14967838 1220260 Here , we report that engagement with Fas ligand *induced* activation of Akt and upregulation of endothelial [nitric oxide synthase] expression without induction of apoptosis . Positive_regulation NOS3 FAS 15317908 1286373 Death promoting effects have been ascribed to inhibition of nuclear factor-kappaB , increase of expression , p53 stabilization , cytokine and chemokine release , and *activation* of [nitric oxide synthase] , p38 , and c-Jun-N-terminal kinase . Positive_regulation NOS3 HBEGF 18925469 1994481 *stimulates* [eNOS] expression and nitric oxide production and promotes eNOS dependent angiogenesis . Positive_regulation NOS3 HBEGF 18925469 1994483 However , the *role* of in regulation of [eNOS] has not yet been investigated . Positive_regulation NOS3 HBEGF 18925469 1994485 significantly upregulated expression of eNOS mRNA , *stimulated* [eNOS] protein production , and increased NO release from HUVEC . Positive_regulation NOS3 HBEGF 19559571 2110493 *induced* VEGF production and [eNOS] activation depend on both PI3 kinase and MAP kinase in HaCaT cells . Positive_regulation NOS3 HBEGF 19559571 2110495 Although endothelial nitric oxide synthase (eNOS) and vascular endothelial growth factor ( VEGF ) appear to be involved in mitogenesis and chemotaxis in epidermal keratinocytes , the activation of [eNOS] and VEGF production *induced* by and its signaling mechanism remains undefined . Positive_regulation NOS3 HBEGF 19559571 2110497 We examined possible signal transduction pathways by which *leads* to [eNOS] activation and VEGF production in human epidermal keratinocyte cell line ( HaCaT cells ) . Positive_regulation NOS3 HBEGF 19559571 2110514 The *induced* [eNOS] activation was significantly blocked by the p42/p44 MAPK inhibitor U0126 and the phosphatidylinositol 3-kinase ( P13K ) inhibitor LY294002 . Positive_regulation NOS3 HBEGF 19559571 2110522 Finally , the *induced* activation of Akt and [eNOS] was suppressed by VEGF competitive antagonist , CBO-P11 . Positive_regulation NOS3 HBEGF 19559571 2110523 These results demonstrate that *induced* [eNOS] activation depends on p42/p44 MAPK , PI3K/Akt pathways and endogenous VEGF in HaCaT cells . Positive_regulation NOS3 IGFBP1 22357965 2572186 *induced* vasodilatation independently of IGF and increased [endothelial NO synthase (eNOS)] activity in arterial segments ex vivo , while in endothelial cells , hIGFBP1 increased eNOS Ser ( 1177 ) phosphorylation via phosphatidylinositol 3-kinase signaling . Positive_regulation NOS3 IL1B 10365824 621120 We have previously reported that the inflammatory cytokine *induced* the expression of the inducible [nitric oxide synthase] gene in primary cultured rat hepatocytes . Positive_regulation NOS3 IL1B 10406194 629400 *increased* levels of inducible [nitric oxide synthase] protein and inducible nitric oxide synthase mRNA , as well as nitric oxide production , in the cultured hepatocytes . Positive_regulation NOS3 IL1B 10406194 629403 FK506 markedly inhibited the nitric oxide formation , inducible [nitric oxide synthase] protein synthesis and inducible nitric oxide synthase mRNA expression *induced* by , but cyclosporin A had no effects . Positive_regulation NOS3 IL1B 10523329 653403 N-acetyl-L-cysteine enhances *induced* [nitric oxide synthase] expression . Positive_regulation NOS3 IL1B 10523329 653406 The effect of N-acetyl-L-cysteine on *induced* [nitric oxide synthase] expression was studied in rat vascular smooth muscle cells to determine if the reduction/oxidation state would modulate cytokine induced changes . Positive_regulation NOS3 IL1B 10593906 572866 Both p38alpha ( MAPK ) and JNK/SAPK pathways are important for *induction* of [nitric-oxide synthase] by in rat glomerular mesangial cells . Positive_regulation NOS3 IL1B 10702213 672497 Superoxide enhances *mediated* transcription of the hepatocyte-inducible [nitric oxide synthase] gene . Positive_regulation NOS3 IL1B 10775561 686637 N-Acetyl-L-cysteine potentiates *induction* of [nitric oxide synthase] : role of p44/42 mitogen activated protein kinases . Positive_regulation NOS3 IL1B 10871193 706787 However , normal mediated translocation of NF-kappaB and *induction* of inducible [nitric oxide synthase] expression and nitric oxide production was severely impaired in the INS-1res cell lines , suggesting a mechanism for the IL-1beta resistance . Positive_regulation NOS3 IL1B 10882405 709474 4. Moreover , CGP-43182 completely blocked *induced* gene expression of the inducible [nitric oxide synthase] , leading to an inhibition of cytokine stimulated nitric oxide formation . Positive_regulation NOS3 IL1B 10967106 751781 Inducible [nitric oxide synthase] mRNA accumulation and nitrite production , which *required* the simultaneous presence of and IFN-gamma , were also suppressed by approximately 70 % , and these cells were more resistant to cytokine induced apoptosis as compared with parental cells . Positive_regulation NOS3 IL1B 10967106 751786 These results demonstrate that is *involved* in inducible [nitric oxide synthase] gene expression and induction of apoptosis in mouse beta cells but does not contribute to impaired glucose stimulated insulin secretion . Positive_regulation NOS3 IL1B 11024034 767725 The resistance to IL-1 beta plus IFN-gamma in STAT-1 alpha expressing cells is due in part to interference with *mediated* stimulation of inducible [nitric-oxide synthase] expression and nitric oxide production . Positive_regulation NOS3 IL1B 11222532 787689 The purpose of these studies was to investigate the *role* of interferon-gamma (IFN-gamma) , tumor necrosis factor-alpha (TNF-alpha) , , and transforming growth factor-beta ( TGF-beta ) in the regulation of inducible [nitric oxide synthase] ( NOS2 ) activity in rabbit corneal cells . Positive_regulation NOS3 IL1B 11287034 799932 Aspirin dose dependently inhibits the *stimulated* increase in inducible [nitric oxide synthase] , nitric oxide , and prostaglandin E ( 2 ) production in rat ovarian dispersates cultured in vitro . Positive_regulation NOS3 IL1B 11457450 838167 15-deoxy-Delta12,14-prostaglandin J2 ( 15d-PGJ2 ) , in contrast to troglitazone , was highly potent to counteract *induced* cyclooxygenase-2 and inductible [nitric oxide synthase] expression , NO production and the decrease in proteoglycan synthesis . Positive_regulation NOS3 IL1B 11506125 847935 Halothane but not isoflurane attenuates *induced* [nitric oxide synthase] in vascular smooth muscle . Positive_regulation NOS3 IL1B 11956484 931197 The induction of inducible [nitric oxide synthase] in the urothelium appears to *depend* on the synergistic effect of and TNF-alpha . Positive_regulation NOS3 IL1B 12209512 983972 Epigallocatechin-3-gallate inhibits *induced* expression of [nitric oxide synthase] and production of nitric oxide in human chondrocytes : suppression of nuclear factor kappaB activation by degradation of the inhibitor of nuclear factor kappaB . Positive_regulation NOS3 IL1B 12365794 995290 in intra-islet macrophages may *induce* Fas and inducible [nitric oxide synthase] expression in an autocrine and paracrine manner and mediate beta cell destruction or even death of some macrophages and T cells . Positive_regulation NOS3 IL1B 12374621 996601 Green tea polyphenol epigallocatechin-3-gallate inhibits the *induced* activity and expression of cyclooxygenase-2 and [nitric oxide synthase-2] in human chondrocytes . Positive_regulation NOS3 IL1B 12390534 1000542 In contrast , chlomethiazole and SB203580 potently inhibited the *induced* expression of c-fos and inducible [nitric oxide synthase] , as monitored by northern blot and quantitative RT-PCR , respectively . Positive_regulation NOS3 IL1B 12390534 1000545 Because *induced* expression of c-fos and inducible [nitric oxide synthase] is believed to directly contribute to the pathology of cerebral ischaemic injury , the results suggest a direct mechanism for the neuroprotective effects of chlomethiazole and SB203580 , and further establish the anti-inflammatory properties of chlomethiazole . Positive_regulation NOS3 IL1B 12475221 1023539 In rat pancreatic islets and insulin producing cell lines , *induces* expression of inducible [nitric oxide synthase] and NO production leading to impairment of glucose stimulated insulin release and decreased cell survival . Positive_regulation NOS3 IL1B 1378360 190622 Balloon injury and *induce* [nitric oxide synthase] activity in rat carotid arteries . Positive_regulation NOS3 IL1B 1380466 195899 Furthermore , markedly *increased* the mRNA levels of the inducible macrophage form of [nitric oxide synthase] in HIT cells . Positive_regulation NOS3 IL1B 15450943 1300774 Inhibitory effects of epicatechin on induced *inducible* [nitric oxide synthase] expression in RINm5F cells and rat pancreatic islets by down-regulation of NF-kappaB activation . Positive_regulation NOS3 IL1B 15591777 1346249 Heme oxygenase-1 attenuates *induced* [nitric oxide synthase] expression in vascular smooth muscle cells . Positive_regulation NOS3 IL1B 15683716 1370647 Catalase potentiates *induced* expression of [nitric oxide synthase] in rat vascular smooth muscle cells . Positive_regulation NOS3 IL1B 15963682 1423160 Inhibitory effect of Buthus martensi Karsch extracts on *induced* expression of [nitric oxide (NO) synthase] and production of NO in human chondrocytes and LPS induced NO and prostaglandin E2 production in mouse peritoneal macrophages . Positive_regulation NOS3 IL1B 16497991 1548959 These results indicate that and BPS antagonistically *regulates* the [eNOS] expression through the activation of p38 and PKA , respectively . Positive_regulation NOS3 IL1B 16782700 1590857 increased endothelial cell endothelial nitric oxide (NO) synthase ( eNOS ) expression but did not *enhance* [eNOS] activity as evidenced by release of NO ( x ) into conditioned medium in response to acetylcholine or shear stress . Positive_regulation NOS3 IL1B 17510469 1761926 induced expression and *activation* of inducible [nitric oxide synthase] and cyclooxygenase-2 were inhibited by apoE in vascular smooth muscle cells ( VSMCs ) . Positive_regulation NOS3 IL1B 17543124 1762551 Malarial pigment haemozoin , IFN-gamma , TNF-alpha , and LPS do not *stimulate* expression of inducible [nitric oxide synthase] and production of nitric oxide in immuno purified human monocytes . Positive_regulation NOS3 IL1B 19595066 2105456 [ Glutamine inhibits *induced* nitric oxide production and inducible [nitric oxide synthase] expression : experiment with cultured rat hepatocytes ] . Positive_regulation NOS3 IL1B 19763723 2247724 In vitro , muscone reversed *induced* upregulation of IL-1beta , tumor necrosis factor alpha , cyclooxygenase 2 , inducible [nitric oxide synthase] , matrix metalloproteinase 13 , aggrecanase 2 , and nitric oxide and downregulation of Col2alpha1 and aggrecan . Positive_regulation NOS3 IL1B 20141611 2178975 THS-78-5 was also able to attenuate induced *inducible* [nitric oxide synthase] expression and subsequent NO release . Positive_regulation NOS3 IL1B 7487987 322997 Nicotinamide inhibits IRF-1 mRNA induction and prevents *induced* [nitric oxide synthase] expression in pancreatic beta cells . Positive_regulation NOS3 IL1B 7488131 332114 *induced* expression of [nitric oxide synthase] in rat renal mesangial cells is suppressed by cyclosporin A . Positive_regulation NOS3 IL1B 7504472 237419 Growth factor regulation of *induced* [nitric oxide synthase] and GTP : cyclohydrolase expression in cultured smooth muscle cells . Positive_regulation NOS3 IL1B 7505613 237680 *induces* the coexpression of both [nitric oxide synthase] and cyclooxygenase by islets of Langerhans : activation of cyclooxygenase by nitric oxide . Positive_regulation NOS3 IL1B 7506668 240010 Cyclosporin derivatives inhibit *induction* of [nitric oxide synthase] in renal mesangial cells . Positive_regulation NOS3 IL1B 7506700 244447 These findings suggest that interferon gamma directly *induces* the expression of the inducible [nitric oxide synthase] gene , whereas tumor necrosis factor-alpha and induce it , at least in part , via the induction of intermediary protein ( s ) , and that transforming growth factor-beta 1 inhibits cytokine induced nitric oxide production by blocking the posttranscriptional synthesis of inducible nitric oxide synthase . Positive_regulation NOS3 IL1B 7517798 261747 *Induction* of [nitric oxide synthase] gene by in cultured rat cardiocytes . Positive_regulation NOS3 IL1B 7521071 269275 Cyclic nucleotide regulation of *induced* [nitric oxide synthase] expression in vascular smooth muscle cells . Positive_regulation NOS3 IL1B 7526844 280506 Possible role of protein kinase C-epsilon isoenzyme in inhibition of *induction* of [nitric oxide synthase] in rat renal mesangial cells . Positive_regulation NOS3 IL1B 7533726 287714 These observations suggest that pyrrolidine dithiocarbamate prevents the *mediated* expression of the inducible [nitric oxide synthase] without affecting the activity of the constitutive enzyme in the rat aorta . Positive_regulation NOS3 IL1B 7538755 306886 Ethanol potentiates stimulated *inducible* [nitric oxide synthase] expression in cultured vascular smooth muscle cells . Positive_regulation NOS3 IL1B 7539260 307000 We presently investigated the effects of pyrrolidine dithiocarbamate ( PDTC ) , a potent inhibitor of nuclear factor kappa B (NF-kappa B) , on the *induction* of [nitric oxide synthase] ( iNOS ) and manganese superoxide dismutase ( MnSOD ) mRNAs by in insulin producing RIN cells . Positive_regulation NOS3 IL1B 7588208 329808 *induced* [nitric oxide synthase] expression by rat pancreatic beta-cells : evidence for the involvement of nuclear factor kappa B in the signaling mechanism . Positive_regulation NOS3 IL1B 7686532 222269 These data demonstrate for the first time that *induces* gene expression of inducible [nitric oxide synthase] and its de novo protein synthesis in rat vascular smooth muscle cells , thereby leading to generation of nitric oxide via Ca2+/calmodulin independent and protein kinase C-independent mechanisms . Positive_regulation NOS3 IL1B 7688219 225319 Endothelial cell nitric oxide synthase ( the constitutive enzyme ) was stimulated with bradykinin , and vascular smooth muscle cell [nitric oxide synthase] ( the inducible enzyme ) was *induced* with . Positive_regulation NOS3 IL1B 7689226 225724 resulting from cleavage of pIL-1 beta by SPE B *induced* [nitric oxide synthase] activity in vascular smooth muscle cells and killed of the human melanoma A375 line . Positive_regulation NOS3 IL1B 7689587 225790 *Induction* of [nitric oxide synthase] activity in human astrocytes by and interferon-gamma . Positive_regulation NOS3 IL1B 8224196 234760 Damage also resulted following *induction* of [nitric oxide synthase] by the cytokine in both islets and HIT-T15 cells and was prevented by replacing the substrate , arginine , with nitromonomethyl arginine . Positive_regulation NOS3 IL1B 8224196 234763 Thus intracellular levels of nitric oxide generated by *induced* [nitric oxide synthase] were sufficient to cause DNA damage in islet cells and HIT-T15 cells . Positive_regulation NOS3 IL1B 8440413 213321 The purpose of this investigation was to determine if brief exposures of islets to IL-1 beta are sufficient to induce the formation of nitric oxide and to examine the signaling process associated with *induced* expression of [nitric oxide synthase] . Positive_regulation NOS3 IL1B 8630528 361262 Addition of 3-isobutyl-1-methyl xanthine resulted in a threefold reduction in the mRNA level of *induced* inducible [nitric oxide synthase] . Positive_regulation NOS3 IL1B 8662809 367294 Suppression of *induced* [nitric-oxide synthase] promoter/enhancer activity by transforming growth factor-beta1 in vascular smooth muscle cells . Positive_regulation NOS3 IL1B 8737749 376973 Here we show that in cultured bovine chondrocytes and explants of human osteoarthritic cartilage both [nitric oxide synthase] and cyclooxygenase activities were *induced* by the inflammatory mediators , lipopolysaccharide , and or tumor necrosis factor-alpha . Positive_regulation NOS3 IL1B 8977400 408786 Induction of guanosine triphosphate-cyclohydrolase by follicle stimulating hormone enhances *stimulated* [nitric oxide synthase] activity in granulosa cells . Positive_regulation NOS3 IL1B 9237621 445654 *Induction* of inducible [nitric oxide synthase] by tumor necrosis factor-alpha , interferon-gamma and inhibited cell proliferation and led to a G1 arrest . Positive_regulation NOS3 IL1B 9339386 458456 Transforming growth factor-beta 2 inhibits *induced* expression of inducible [nitric oxide synthase] in rat renal mesangial cells . Positive_regulation NOS3 IL1B 9369275 464004 Exogenous angiotensin II inhibited *stimulated* inducible [nitric oxide synthase] protein expression in both deendothelialized vessels and those with endothelium , although with reduced ability on the aortic segments with endothelium by a nitric oxide independent mechanism . Positive_regulation NOS3 IL1B 9369275 464007 In the aortic rings with endothelium , either inhibition of the AT-1 receptor with losartan or blocking of angiotensin II generation with fosinopril enhanced stimulated *inducible* [nitric oxide synthase] protein expression . Positive_regulation NOS3 IL1B 9395303 468383 Insulin-like growth factor I reverses inhibition of insulin secretion , *induction* of [nitric oxide synthase] and cytokine mediated apoptosis in rat islets of Langerhans . Positive_regulation NOS3 IL1B 9652398 515857 However , in these cells , *induction* of inducible [nitric oxide synthase] , granulocyte-macrophage colony stimulating factor and cyclooxygenase-2 mRNA showed 70-90 % repression by dexamethsone . Positive_regulation NOS3 MAP2K6 12527803 1048485 In summary , H ( 2 ) O ( 2 ) causes endothelial NO* release mediated by cooperative effects between PI 3-kinase/Akt dependent [eNOS] serine 1179 phosphorylation and *activation* of . Positive_regulation NOS3 MAP2K6 15226277 1273998 An Src kinase inhibitor , pp2 , and inhibitor , PD98059 , *blocked* the ERK1/2 phosphorylation and [eNOS] expression . Positive_regulation NOS3 MAP2K6 16877565 1638837 However , inhibitors of Raf-1 and or a dominant negative ERK mutant *blocked* FKN induced ERK , but not Akt and [eNOS] , phosphorylation . Positive_regulation NOS3 MAP2K6 22219320 2544465 The induction of [eNOS] expression by IL-17 was *prevented* by the pharmacological inhibition of NF-?B , , and JNK , as well as by small interfering RNA mediated gene silencing of these signaling pathways . Positive_regulation NOS3 NOSTRIN 16807357 1606003 In CHO-eNOS cells , *mediated* translocation of [eNOS] involves caveolin in a process most likely representing caveolar trafficking . Positive_regulation NOS3 NOSTRIN 17570224 1753728 *induces* intracellular translocation of [eNOS] and reduces NO generation . Positive_regulation NOS3 PECAM1 16118242 1454347 *Role* of in the shear-stress induced activation of Akt and the [endothelial nitric oxide synthase (eNOS)] in endothelial cells . Positive_regulation NOS3 PECAM1 16118242 1454353 Since a major constituent of these endothelial cell-cell contacts is the platelet endothelial cell adhesion molecule-1 ( PECAM-1 ) we assessed the *role* of in the activation of [eNOS] . Positive_regulation NOS3 PECAM1 16118242 1454358 Down-regulation of using a siRNA approach *attenuated* the shear-stress induced phosphorylation of Akt and [eNOS] , as well as the shear-stress induced accumulation of cyclic GMP levels while the shear-stress induced phosphorylation of AMPK remained intact . Positive_regulation NOS3 PECAM1 21183735 2391099 The current study was conducted to determine the *role* of in the regulation of basal [eNOS] activity . Positive_regulation NOS3 PGC 21435455 2406404 In addition to inactivation of forkhead transcription factor signaling through enhanced Akt/protein kinase B expression , in glycolytic muscles , overexpression *led* to enhanced expression of inducible nitric oxide synthase and endothelial [nitric oxide synthase] , production of nitric oxide , and expression of antioxidant enzyme including superoxide dismutases ( SOD1 , SOD2 , and SOD3 ) and catalase , and reduced oxidative stress . Positive_regulation NOS3 PLAT 17717150 1801541 In conclusion , our results demonstrate that after MCAO the interaction between and LRP *results* in NF-kappaB activation in astrocytes and induction of inducible [nitric-oxide synthase] expression in the ischemic tissue , suggesting a cytokine-like plasminogen independent role for tPA during cerebral ischemia . Positive_regulation NOS3 PLAU 21540184 2444675 ( uPA ) *induces* pulmonary microvascular endothelial permeability through low density lipoprotein receptor related protein ( LRP ) -dependent activation of endothelial [nitric-oxide synthase] . Positive_regulation NOS3 PLAU 21540184 2444677 *induced* phosphorylation of [eNOS] was decreased by anti-low density lipoprotein receptor related protein-1 ( LRP ) antibody and an LRP antagonist , receptor associated protein (RAP) , and when binding to the uPA receptor was blocked by the isolated growth factor-like domain of uPA . Positive_regulation NOS3 PLAU 21540184 2444713 *induced* phosphorylation of [eNOS] was also inhibited by the protein kinase A (PKA) inhibitor , myristoylated PKI , but was not dependent on PI3K-Akt signaling . Positive_regulation NOS3 S100B 10627310 658982 The astrocyte derived *stimulates* production of inducible [nitric oxide synthase] and nitric oxide ( NO ) in astrocytes [ Hu et al. , 1996 , J. Biol. Chem. 271 : 2543 ] , but its effect on microglia is not known . Positive_regulation NOS3 S100B 12045670 950151 An astrocytic protein *enhances* the expression of inducible [nitric oxide synthase] in cultured astrocytes at micromolar concentrations , leading to nitric oxide mediated death of cocultured neurons . Positive_regulation NOS3 S100B 8576219 350271 *stimulates* inducible [nitric oxide synthase] activity and mRNA levels in rat cortical astrocytes . Positive_regulation NOS3 S1PR3 15334188 1291022 Finally , S1P also protects endothelial cells from apoptosis through *activation* of phosphatidylinositol [3-kinase/Akt/eNOS] via S1P(1) and receptors . Positive_regulation NOS3 SPHK1 16269668 1502338 Endothelial [nitric oxide synthase] *activation* by tumor necrosis factor alpha through neutral sphingomyelinase 2 , , and sphingosine 1 phosphate receptors : a novel pathway relevant to the pathophysiology of endothelium . Positive_regulation NOS3 SPHK1 16857953 1600467 *dependent* activation of endothelial [nitric oxide synthase] by angiotensin II . Positive_regulation NOS3 TLR7 10426995 632978 Several lipoproteins stimulated *dependent* transcription of inducible [nitric oxide synthase] and the production of nitric oxide , a powerful microbicidal pathway . Positive_regulation NOS3 TLR7 15994412 1447013 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for tumor necrosis factor ( TNF-alpha ) , interleukin 6 , [nitric oxide synthase-II] ( iNOS ) , and NADPH oxidase 2 (Nox2) . Positive_regulation NOS3 TNF 10084320 599196 A strong effect on inducible [nitric oxide synthase] gene expression could be *detected* when the cells were coincubated with the proinflammatory cytokines interferon-gamma and with inducible nitric oxide synthase cDNA concentrations averaging 11.7 +/- 0.6 amol per microg total RNA at 24 h , and 25.0 +/- 1.4 amol per microg total RNA at 48 h , respectively . Positive_regulation NOS3 TNF 10356322 618391 We investigated the molecular mechanism for the synergistic *induction* of inducible [nitric oxide synthase] transcription by and IFN-gamma . Positive_regulation NOS3 TNF 10713108 675822 Beta-amyloid stimulation of inducible [nitric-oxide synthase] in astrocytes is interleukin-1beta- and *dependent* , and involves a TNFalpha receptor associated factor- and NFkappaB inducing kinase dependent signaling mechanism . Positive_regulation NOS3 TNF 10929773 719753 Ultraviolet B radiation downregulates inducible [nitric oxide synthase] expression *induced* by interferon-gamma or in murine keratinocyte Pam 212 cells . Positive_regulation NOS3 TNF 11085984 786353 *Activation* of the endothelial [nitric-oxide synthase] by . Positive_regulation NOS3 TNF 11160388 781725 beta-Amyloid stimulation of microglia and monocytes results in *dependent* expression of inducible [nitric oxide synthase] and neuronal apoptosis . Positive_regulation NOS3 TNF 11224628 787971 In contrast , [nitric oxide synthase] expression is *induced* by IL-1 , , and gamma interferon , a T-helper 1 cytokine profile . Positive_regulation NOS3 TNF 11399519 824232 Interferon (IFN)-gamma and Herpes simplex synergistically *induce* [nitric oxide synthase] 2 in macrophages through cooperative action of nuclear factor-kappa B and IFN regulatory factor-1 . Positive_regulation NOS3 TNF 11517169 851239 This action of GH may be sufficient to suppress the synergistic *induction* of inducible [nitric oxide synthase] by interferon-gamma and , thereby preventing the cytotoxicity to beta-cells . Positive_regulation NOS3 TNF 11826414 909390 Activation of [eNOS] in rat portal hypertensive gastric mucosa is *mediated* by via the PI 3-kinase-Akt signaling pathway . Positive_regulation NOS3 TNF 11826414 909393 To determine human relevance , we used human microvascular endothelial cells to examine directly whether *stimulates* [eNOS] phosphorylation via PI 3-kinase . Positive_regulation NOS3 TNF 11826414 909394 Furthermore , *stimulated* [eNOS] phosphorylation in human microvascular endothelial cells . Positive_regulation NOS3 TNF 11826414 909395 In conclusion , these findings show that in PHT gastric mucosa , *stimulates* [eNOS] phosphorylation at serine 1177 ( required for its activation ) via the PI 3-kinase-Akt signal transduction pathway . Positive_regulation NOS3 TNF 11956484 931196 The induction of inducible [nitric oxide synthase] in the urothelium appears to *depend* on the synergistic effect of IL-1beta and . Positive_regulation NOS3 TNF 12884305 1116568 *mediates* the induction of [nitric oxide synthase] in macrophages but not in neutrophils in experimental cutaneous leishmaniasis . Positive_regulation NOS3 TNF 15808421 1391136 Similarly , DEM and CDNB inhibited *induced* Akt and [eNOS] phosphorylation , suggesting that thiol modification is involved in eNOS inductive pathways . Positive_regulation NOS3 TNF 16269668 1502349 In human endothelial cells , we found that [eNOS] *activation* by is time dependent and requires activation of Akt , a known eNOS activator . Positive_regulation NOS3 TNF 16269668 1502359 Thus , [eNOS] is *activated* by via S1P receptors , activated by Sph1P generated through N-SMase2 and SK1 activation . Positive_regulation NOS3 TNF 16328964 1503645 Both and inosine *increased* nitrite accumulation and [nitric oxide synthase] activity . Positive_regulation NOS3 TNF 16827641 1586617 The *role* of in mediating pathophysiological activity of inducible [nitric oxide synthase] during transplant vasculopathy remains contentious . Positive_regulation NOS3 TNF 16873093 1593283 On the other hand , BMK strongly inhibited interleukin-1beta (IL-1beta)- and *induced* [Nitricoxide (NO) synthase] expression with little effect on constitutive NO synthase expression . Positive_regulation NOS3 TNF 16940413 1639231 It suppressed the transcription of NF-kappaB downstream gene products including cyclooxygenase-2 and inducible [nitric-oxide synthase] *induced* by or lipopolysaccharide in macrophages and hepatocarcinoma cells . Positive_regulation NOS3 TNF 16945356 1633154 We demonstrate that prolonged shear stress has a potential that is superior to that of statins to induce the KLF2 dependent expression of [eNOS] and TM , especially in the *presence* of the pro-inflammatory cytokine . Positive_regulation NOS3 TNF 17851925 1910972 *Induction* of inducible [nitric oxide synthase] and apoptosis by LPS and in nasal microvascular endothelial cells . Positive_regulation NOS3 TNF 18275839 1937996 In Caco-2 cells , Hex ( 2.5-20 microM ) inhibited *induced* NF-kappaB activation ( IkappaB phosphorylation and degradation , p50 and RelA nuclear translocation , and NF-kappaB-DNA binding ) , inducible [nitric oxide synthase] expression , and cell oxidant increase . Positive_regulation NOS3 TNF 18295395 1896689 Our results showed that CS inhibited *induced* NF-kappaB activation and subsequent vascular cell adhesion molecule 1 and inducible [nitric oxide synthase] expressions by blocking Akt signals in JB6 cells . Positive_regulation NOS3 TNF 18422522 1926164 We found that [eNOS] , which is endogenously expressed by these cells , was *activated* by , a proinflammatory cytokine that plays important roles in ALS2 and several neurodegenerative diseases . Positive_regulation NOS3 TNF 18422522 1926165 The *dependent* [eNOS] activation occurred through generation , by sphingosine-kinase-1 , of sphingosine-1-phosphate , stimulation of its membrane receptors and activation of Akt , as determined using small interference RNA and dominant negative constructs specific for the enzymes and receptors . Positive_regulation NOS3 TNF 18422522 1926166 [eNOS] *activation* by conferred cytoprotection from excitotoxicity and neurotoxic cues such as reactive oxygen species , endoplasmic reticulum stress , DNA damage , and mutated alsin itself . Positive_regulation NOS3 TNF 18713021 1974726 We found that inhibition of DNA topoisomerase I , but not Cdc2-like kinases , prevents the *induced* increase in [eNOS] isoform expression and NO reduction in HUVEC . Positive_regulation NOS3 TNF 18713021 1974728 Our results demonstrate , for the first time , that DNA topoisomerase I but not Cdc2-like kinases serves as an important regulator of the differential eNOS isoform expression in endothelial cells , thereby modulating the *induced* [eNOS] activity switch . Positive_regulation NOS3 TNF 20135642 2235877 Integrin linked kinase is involved in induced *inducible* [nitric-oxide synthase] expression in myoblasts . Positive_regulation NOS3 TNF 20489729 2327430 *induced* activation of p38 MAPK and the production of inducible [nitric oxide synthase] were suppressed in ASK1-deficient Müller glial cells . Positive_regulation NOS3 TNF 20675566 2322641 This improvement is due to the role of resveratrol in inhibiting induced NF-?B activation , therefore subsequently *inhibiting* the expression and activation of NAD(P)H oxidase and iNOS as well as increasing [eNOS] expression in type 2 diabetes . Positive_regulation NOS3 TNF 20884819 2357071 Positive immunolabelings for interleukin-6 , *inducible* [nitric oxide synthase] , and dimeric copper- and zinc containing superoxide dismutase were observed mainly in the inflammatory cells in the lesions ; Positive_regulation NOS3 TNF 21637955 2531999 Aldose reductase regulates induced *inducible* [nitric oxide synthase] expression in human mesangial cells . Positive_regulation NOS3 TNF 22005300 2503244 Surprisingly , MDL-1 induced NO and production *required* [eNOS] but not iNOS . Positive_regulation NOS3 TNF 22280454 2560020 Ankaflavin and monascin regulate endothelial adhesion molecules and [endothelial NO synthase (eNOS)] expression *induced* by in human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation NOS3 TNF 22510373 2613310 *increased* [endothelial nitric oxide synthase (eNOS)] phosphorylation at Thr495 and decreased total eNOS expression and both basal and stimulated eNOS activity . Positive_regulation NOS3 TNF 23266106 2741429 NF-?B p50 gene deletion blocked NF-?B activation , *inhibited* expression , prevented [eNOS] down-regulation and reversed the impaired endothelium dependent vasodepressor response induced by CIH . Positive_regulation NOS3 TNF 23427281 2887212 The *induces* [eNOS] and MMP-9 expression and PKB activation . Positive_regulation NOS3 TNF 23462755 2760704 *induced* intercellular adhesion molecule-1 ( ICAM-1 ) and [endothelial nitric oxide synthase (eNOS)] phosphorylation were measured with and without ROCK inhibition by fasudil or ROCK-specific small interfering RNA ( siRNA ) . Positive_regulation NOS3 TNF 23527096 2761985 In addition , NaHS treatment prevented the increase of nitric oxide , Intercellular Adhesion Molecule 1 ( ICAM-1 ) and interleukin (IL)-6 production and inducible [nitric oxide synthase] activation *induced* by . Positive_regulation NOS3 TNF 23941776 2835882 *increased* [eNOS] mRNA level and NO metabolite ( nitrite ) production during CL growth . Positive_regulation NOS3 TNF 24401210 2900321 T0901317 influenced NO metabolism as indicated by a decrease in TNF-a upregulated arginase activity , a reversal of *induced* downregulation of argininosuccinate synthase mRNA expression and [eNOS] expression to basal levels and a raise in NO production . Positive_regulation NOS3 TNF 24905701 2952092 Furthermore , HMGB1 and IL-1ß and/or a ( but not HMGI/Y ) also significantly *induced* inducible [nitric oxide synthase] , NO , and interleukin (IL)-8 production in human cartilage and chondrocytes . Positive_regulation NOS3 TNF 7504484 237424 Nitric oxide and [nitric oxide synthase] mRNA *induction* in mouse islet cells by interferon-gamma plus . Positive_regulation NOS3 TNF 7506700 244445 These findings suggest that interferon gamma directly *induces* the expression of the inducible [nitric oxide synthase] gene , whereas and interleukin-1 beta induce it , at least in part , via the induction of intermediary protein ( s ) , and that transforming growth factor-beta 1 inhibits cytokine induced nitric oxide production by blocking the posttranscriptional synthesis of inducible nitric oxide synthase . Positive_regulation NOS3 TNF 7509010 240175 Dexamethasone inhibits [nitric oxide synthase] mRNA *induction* by interleukin-1 alpha and in vascular smooth muscle cells . Positive_regulation NOS3 TNF 7529496 291454 The inflammatory mediators interleukin-1 beta (IL-1 beta) , and the bacterial cell wall fragment endotoxin , *induced* both [nitric oxide synthase] activity and stromelysin and collagenase activity in whole cell preparations and in conditioned media from explants of bovine and human cartilage . Positive_regulation NOS3 TNF 7573346 324959 Thus , interleukin-1 alpha and inducible [nitric oxide synthase] were *induced* mostly in the cells accumulated around the beads and also in some bronchiolar epithelial cells during the early phase ( 1 to 3 days ) , whereas was induced in the cells around the beads at the later resolution phase ( 3 to 7 days ) . Positive_regulation NOS3 TNF 8549863 346494 Used alone or in combination , and IFN significantly *enhanced* the activity of inducible [nitric oxide synthase] as determined by measuring the conversion of 14C labeled arginine to 14C labeled citrulline and nitric oxide . Positive_regulation NOS3 TNF 8737749 376972 Here we show that in cultured bovine chondrocytes and explants of human osteoarthritic cartilage both [nitric oxide synthase] and cyclooxygenase activities were *induced* by the inflammatory mediators , lipopolysaccharide , and interleukin-1 beta or . Positive_regulation NOS3 TNF 8746212 344051 Experimental and clinical evidence suggests that *induces* the expression of vascular [nitric oxide (NO) synthase] within hours and that NO released from smooth muscle cells could be involved in the pathogenesis of septic shock . Positive_regulation NOS3 TNF 8779862 379924 *Roles* of IL-1 and in endotoxin induced activation of [nitric oxide synthase] in cultured rat brain cells . Positive_regulation NOS3 TNF 8861703 388541 These data suggest that vasodilation by LPS is mainly due to nitric oxide predominantly synthesized by an inducible [nitric oxide synthase] , proximally *induced* by . Positive_regulation NOS3 TNF 8917029 395975 The hypothesis that in humans , *induces* vasodilation and shock through activation of inducible [nitric-oxide synthase] and subsequent formation of excessive quantities of nitric oxide is not substantiated by our results . Positive_regulation NOS3 TNF 9215702 441814 The isoform of the [nitric oxide synthase] *induced* in human neuroblastoma cells by treatment was identified enzymatically as isoform II by Western blotting and by the polymerase chain reaction . Positive_regulation NOS3 TNF 9693272 523367 Single stimulation of smooth muscle cells with either neopterin or *caused* inducible [nitric oxide synthase] gene expression and nitric oxide production . Positive_regulation NOS3 TNF 9834372 479675 *regulates* inducible [nitric oxide synthase] gene expression in the portal hypertensive gastric mucosa of the rat . Positive_regulation NOS3 TNF 9875639 557219 In transformed hepatic stellate cells , and interferon-gamma have a crucial role in nitric oxide production , and extracellular L-arginine transport and inducible [nitric oxide synthase] expression are *regulated* in a differential cytokine-specific manner . Positive_regulation NOS3 TNFSF10 16229016 1517957 Although an important factor that regulates eNOS activity is its localization within the cells , little is known about the *role* of in the regulation of [eNOS] trafficking among cellular compartments and the cytoskeleton involvement in this machinery . Positive_regulation NOS3 TNFSF10 17540725 1778505 In addition , GAPDH small interfering RNA partially prevented the apoptotic effect of TRAIL , although *induced* [nitric oxide synthase] stimulation and production of nitric oxide were not attenuated . Positive_regulation NOSTRIN NOS3 17570224 1753727 [NOSTRIN] *induces* intracellular translocation of and reduces NO generation . Positive_regulation NOSTRIN PECAM1 21183735 2391101 Furthermore , we demonstrate that activation of blunted signal transducers and activators of transcription 3 ( STAT3 ) in the absence of *results* in decreased [NOSTRIN] expression via direct binding of the signal transducers and activators of transcription 3 to the NOSTRIN promoter . Positive_regulation NOTCH1 CCND1 20443831 2009607 ErbB2 induced cyclin D1 and cyclin D1 expression was suficient to induce Notch1 activity , and conversely , genetic deletion of Notch1 in mammary epithelial cells using foxed Notch ( Notch ( fl/fl ) ) mice demonstrated that is *induced* by [Notch1] . Positive_regulation NOTCH1 CDKN1C 16033893 1436232 Here , we report that , in zebrafish , expression of the Cdki gene cyclin dependent kinase inhibitor 1c ( cdkn1c ) , a p57 homolog , is negatively regulated by [Delta-Notch] signaling and that function is *required* for neural plate cells to stop dividing and differentiate as neurons on schedule , even in the absence of Notch signaling activity . Positive_regulation NOTCH1 HBEGF 24188029 2921119 RT-qPCR analysis demonstrated that HB-EGF affected the expression of Notch signaling pathway genes , implying a role for the [Notch] signaling in *mediated* astrocyte response . Positive_regulation NOTCH1 HES2 16682003 1559634 Hrt and negatively *regulate* [Notch] signaling through interactions with RBP-Jkappa . Positive_regulation NOTCH1 JAG1 11707585 879626 Fringe modulation of *induced* [Notch] signaling requires the action of beta 4galactosyltransferase-1 . Positive_regulation NOTCH1 JAG1 11707585 879630 Although the beta 3GlcNAcT activity of manic or lunatic fringe is shown to be necessary for inhibition of *induced* [Notch] signaling in a coculture assay , it is not sufficient . Positive_regulation NOTCH1 JAG1 11964309 932754 [Notch1] signaling may therefore be *activated* in tumor cells by through homotypic or heterotypic cell-cell interactions , and it seems likely that these interactions contribute to lymphomagenesis in vivo . Positive_regulation NOTCH1 JAG1 12357247 994177 During mammalian central nervous system ( CNS ) development , contact mediated *activation* of [Notch1] receptors on oligodendrocyte precursors by the ligand induces Hes5 , which inhibits maturation of these cells . Positive_regulation NOTCH1 JAG1 12370358 995874 Our data suggest that *activation* of [Notch] by plays an important role in maturation of human DCs . Positive_regulation NOTCH1 JAG1 12417415 1012994 Interestingly , addition of a beta1,4 galactose by beta4GalT-1 to the GlcNAc added by fringe is required for *induced* [Notch] signaling to be inhibited in a co-culture assay . Positive_regulation NOTCH1 JAG1 14726396 1234979 *induced* [Notch] signaling drives proliferation of multiple myeloma cells . Positive_regulation NOTCH1 JAG1 15192074 1288762 Treatment with 17 beta-estradiol also led to an activation of Notch signaling in MCF7 cells expressing Notch1 reporter gene or by promoting *induced* [Notch] signaling in coculture assays . Positive_regulation NOTCH1 JAG1 15550486 1374892 *dependent* [Notch] signaling is dispensable for hematopoietic stem cell self-renewal and differentiation . Positive_regulation NOTCH1 JAG1 15550486 1374896 In contrast to earlier reports , these data exclude an essential role for *mediated* [Notch] signaling during hematopoiesis . Positive_regulation NOTCH1 JAG1 15574878 1361286 Fringe glycosyltransferases differentially modulate [Notch1] proteolysis *induced* by Delta1 and . Positive_regulation NOTCH1 JAG1 15574878 1361292 Interestingly , suppression of *induced* [Notch1] signaling did not correlate with changes in Jagged1 binding as found for Delta1 . Positive_regulation NOTCH1 JAG1 15695512 1395524 Critical regulation of bone morphogenetic protein induced osteoblastic differentiation by *activated* [Notch1] signaling . Positive_regulation NOTCH1 JAG1 15695512 1395535 These results indicate the functional redundancy between Delta1 and Jagged1 in osteoblastic differentiation whereby *activated* [Notch1] enhances BMP2 induced differentiation through the identical signaling pathway . Positive_regulation NOTCH1 JAG1 16023595 1435206 Here , we report that the Notch ligand induced by growth factors via mitogen activating protein kinase (MAPK) in head and neck squamous cell carcinoma ( HNSCC ) cells *triggered* [Notch] activation in neighboring endothelial cells ( ECs ) and promoted capillary-like sprout formation . Positive_regulation NOTCH1 JAG1 16571776 1555920 Here , we show that activation of the Notch pathway by either *stimulation* of cell surface [Notch] receptors with crosslinked soluble delta-like 4 ( sDll4 ) ( sJag1 ) or constitutive expression of the Notch1 intracellular domain ( N ( IC ) ) suppresses endothelial cell proliferation . Positive_regulation NOTCH1 JAG1 16865239 1592717 NUMB inhibits Notch signaling in progenitor cells to induce differentiation , while *activates* [Notch] signaling in stem cells to maintain self-renewal potential . Positive_regulation NOTCH1 JAG1 16867989 1613513 Physiological [Notch] *stimulation* by its ligand , but not Dll4 , directly induces Sm-mhc expression in 10T1/2 cells without de novo protein synthesis , indicative of a ligand-selective effect . Positive_regulation NOTCH1 JAG1 17003479 1618618 *Stimulation* of [Notch] by its ligand diminished the proliferation of cultured metaplastic exocrine cells . Positive_regulation NOTCH1 JAG1 17259973 1696713 Conversely , *activation* of [Notch] by a soluble peptide leads to fewer tip cells and vessel branches . Positive_regulation NOTCH1 JAG1 17475842 1738422 In the present report we demonstrate that *induced* [Notch] signaling ( using immobilized Jagged-1 fusion protein ) during stimulation of purified human CD4+ and CD8+ T cells potently inhibits T cell proliferation and effector function , including both Th1- and Th2 associated cytokines . Positive_regulation NOTCH1 JAG1 17568183 1815809 and JAG2 *activate* [Notch] signaling , while DKK1 and SFRP1 inhibit WNT signaling . Positive_regulation NOTCH1 JAG1 17652726 1776201 The *activation* of [Notch] by resulted in the upregulation of active forms of Notch1 and 2 proteins ( P < 0.05 ) , with a concurrent increase in Ki67 ( P < 0.05 ) and a decrease in CK3 ( P < 0.05 ) expression . Positive_regulation NOTCH1 JAG1 17967789 1826518 Likewise , *stimulation* of [Notch] signaling by immobilized promoted Wnt5a expression in EPCs . Positive_regulation NOTCH1 JAG1 17984306 1826750 mediated [Notch] *activation* induces epithelial-to-mesenchymal transition through Slug induced repression of E-cadherin . Positive_regulation NOTCH1 JAG1 18256896 1884758 [Notch] *activation* by the and Delta-like 4 ligands regulates different steps of blood vessel development ranging from proliferation and survival of endothelial cells , to vessel branching and arterial-venous differentiation . Positive_regulation NOTCH1 JAG1 18347015 1905813 Nevertheless , they have reduced binding of Notch ligands and low levels of Delta1- and *induced* [Notch] signaling . Positive_regulation NOTCH1 JAG1 18445292 1915679 In an ES cell co-culture assay , [Notch] signaling *induced* by or Delta1 was reduced to a similar level in Notch1 ( lbd ) and Notch1 null cells . Positive_regulation NOTCH1 JAG1 18495362 1921845 *Stimulation* of [Notch] receptors by exposure of mouse cortical neurons to the Notch ligand resulted in increased microtubule stability , as measured by using antibodies against post-translationally modified alpha tubulin , and changes in axonal morphology and branching , with varicosity loss , thicker neurites and enlarged growth cones . Positive_regulation NOTCH1 JAG1 18528438 1934273 Taken together , our results indicate that *mediated* activation of [Notch1] is responsible for regulating GATA2 expression in the AGM , which in turn is essential for definitive haematopoiesis in the mouse . Positive_regulation NOTCH1 JAG1 18710934 1968163 In contrast , *induction* of [Notch] signaling by or by ectopic expression of intracellular Notch2 enhances NFATc1 promoter activity and expression and promotes osteoclastogenesis . Positive_regulation NOTCH1 JAG1 19524514 2092997 Upon glycosylation of Notch , [Dll4-Notch] signaling is *enhanced* , whereas has weak signaling capacity and competes with Dll4 . Positive_regulation NOTCH1 JAG1 19598246 2149798 Recently , another Notch ligand , *dependent* [Notch] activation , has been revealed to be important for the determination of the prosensory region in the earlier stage before cell differentiation . Positive_regulation NOTCH1 JAG1 19915977 2287039 Cyclin D1 is a direct target of *mediated* [Notch] signaling in breast cancer . Positive_regulation NOTCH1 JAG1 19915977 2287048 We show that down-regulation *reduces* direct binding of [Notch] to the cyclin D1 promoter , reduced cyclin D1 expression and inhibition of cell cycle progression through the cyclin D1-dependant G1/S checkpoint . Positive_regulation NOTCH1 JAG1 19935714 2210110 In the human HT29Cl16E colonic carcinoma cell line , induction of goblet cell differentiation by contact inhibition of growth depended on the loss of mediated [Notch] *activation* , with signaling through Notch1 and Notch2 acting redundantly . Positive_regulation NOTCH1 JAG1 20010940 2191380 Epithelial-to-mesenchymal transition is mediated , in part , by two transcription repressors , Snail and Slug , that are known to be targets of the Notch signaling pathway , and induced [Notch] *activation* increases EMT . Positive_regulation NOTCH1 JAG1 20081190 2194400 Fng proteins enhance Dll1 activated Notch signalling and block [Notch] activation *mediated* by . Positive_regulation NOTCH1 JAG1 20157766 2272310 could *activate* [Notch] signaling in the human promyelocytic leukemia cell line HL60 , as shown by a reporter assay and the induced expression of Notch effector gene Hes1 and Hes5 . Positive_regulation NOTCH1 JAG1 20428807 2247364 [Notch] is *activated* by DLL and presents on neighboring cells . Positive_regulation NOTCH1 JAG1 20510365 2289453 In vivo overexpression experiments with Notch ligands suggest that Lfng strongly augments [Notch] signaling *mediated* by Delta-like 1 but not . Positive_regulation NOTCH1 JAG1 20602435 2309650 While *induced* minimal [Notch] signaling , Jagged2 elicited substantial levels of Hes1 transcripts and promoted T lymphopoiesis in vitro . Positive_regulation NOTCH1 JAG1 20837470 2342402 In CHO cells with low levels of Slc35c2 , both Delta1- and *induced* [Notch] signaling were reduced , and the fucosylation of a Notch1 fragment was also decreased . Positive_regulation NOTCH1 JAG1 21124801 2355722 However , can only *activate* [Notch] signalling within the V1 and dI6 domains , whereas Dll1 can signal to neural progenitors both inside and outside its domains of expression . Positive_regulation NOTCH1 JAG1 21151194 2463386 Epithelial and stromal cell populations in the thymus express the Notch DSL ( Delta , Serrate and Lag2 ) ligands Delta-like 1 (Dll1) , Delta-like 4 (Dll4) , and Jagged 2 , and *induce* [Notch] signalling in thymocytes that express the Notch receptor . Positive_regulation NOTCH1 JAG1 21199807 2374289 These data suggest that *induced* [Notch] activation results in breast cancer progression through upregulation of the plasminogen activator system , directly linking these 2 important pathways of poor prognosis . Positive_regulation NOTCH1 JAG1 21685392 2465401 *Activation* of [Notch] signaling by in vascular smooth muscle cells ( VSMC ) promotes a differentiated phenotype characterized by increased expression of contractile proteins . Positive_regulation NOTCH1 JAG1 21685392 2465417 *Activation* of [Notch] receptors by caused CBF1 dependent up-regulation of miR-143/145 , increased differentiation , and decreased proliferation . Positive_regulation NOTCH1 JAG1 21712044 2460738 We also showed that the proliferative response of the neonatal cardiomyocytes involved the *activation* of [Notch-1] receptor by its ligand expressed by the adjacent MSCs . Positive_regulation NOTCH1 JAG1 22081605 2528649 In mutant Chinese hamster ovary ( CHO ) cells that do not add galactose (Gal) to the GlcNAc transferred by Fringe , *induced* [NOTCH] signaling is not inhibited by LFNG or MFNG . Positive_regulation NOTCH1 JAG1 22147907 2536473 [Notch] *activation* of contributes to the assembly of the arterial wall . Positive_regulation NOTCH1 JAG1 22275127 2551531 Requirements for *mediated* [Notch] signaling during early mouse lens development . Positive_regulation NOTCH1 JAG1 22388089 2577110 In particular , we found that during biliary regeneration , expression of ( a Notch ligand ) by myofibroblasts *promoted* [Notch] signaling in HPCs and thus their biliary specification to cholangiocytes . Positive_regulation NOTCH1 JAG1 22427350 2588201 Analysis of clinical data indicates that Jag1 expression correlates with both grade and stage of ACCs , supporting a role of dependent [Notch] *activation* in late-stage ACCs . Positive_regulation NOTCH1 JAG1 22452482 2606751 Endothelial progenitor cells promote astrogliosis following spinal cord injury through *dependent* [Notch] signaling . Positive_regulation NOTCH1 JAG1 23046039 2689808 Moreover , also *increased* expression of [Notch] downstream genes and PPAR-? . Positive_regulation NOTCH1 JAG1 23116754 2751046 In the further experiments , down-regulation of Notch signaling was shown to be critical for BM-MSCs to differentiate into hepatocytes , as increased *resulted* in up-regulated [Notch] activation leading to higher levels of expression of Hes1 and Hey1 , which completely blocked Albumin expresion in BM-MSCs . Positive_regulation NOTCH1 JAG1 23526493 2782374 Our results demonstrate that *mediated* [Notch] signaling regulates multiple cell fate decisions as well as differentiation in the respiratory system to coordinate lung development and to maintain a balance of airway cell types in adult life . Positive_regulation NOTCH1 JAG1 23831026 2815971 We show that shedding of Jag1 is reduced in BACE1 null mice and upregulated *enhances* [Notch] signaling via cell-cell juxtacrine interactions . Positive_regulation NOTCH1 JAG1 23965337 2845530 Overexpression of S-phase kinase associated protein before [Notch] *activation* by suppressed the induction of p27 ( kip1 ) . Positive_regulation NOTCH1 JAG1 23989801 2836402 In addition , *activation* of [Notch1] by or administration of peroxynitrite scavenger reduced production of peroxynitrite and attenuated MI/R injury . Positive_regulation NOTCH1 JAG1 24115357 2896444 We show that the transplantation of hESC derived OPC and MP promotes astrogliosis , through activation of *dependent* [Notch] and Jak/STAT signaling that support axonal survival . Positive_regulation NOTCH1 JAG1 24140644 2868116 In conclusion , it seems that HCs fine-tune liver inflammation by upregulation of and *activation* of [Notch] signaling in Th1 cells . Positive_regulation NOTCH1 JAG1 25309874 2959377 In fact , *stimulated* [Notch] activation is directly implicated in tumor growth through maintaining cancer stem cell populations , promoting cell survival , inhibiting apoptosis , and driving cell proliferation and metastasis . Positive_regulation NOTCH1 MAML3 16966428 1627805 These findings indicate that the Notch requirement during the beta-selection checkpoint in vivo is absolute and independent of the pre-TCR , and it depends on transcriptional *activation* by [Notch] via the complex . Positive_regulation NOTCH1 MAML3 19349467 2057579 *dependent* [Notch1] signaling controls T lineage-specific IL-7R{alpha } gene expression in early human thymopoiesis and leukemia . Positive_regulation NOTCH1 MAML3 21302306 2480158 We found that FGF1 export and expression are regulated through [Notch] signaling *mediated* by transcription factor CBF1 and its partner . Positive_regulation NOTCH1 MAML3 21640102 2446184 is *required* for stable formation of [Notch] transcriptional complexes at the promoters of Notch target genes . Positive_regulation NOTCH1 MAML3 21640102 2446205 Overexpression of by retroviral transduction in CaSki cells *resulted* in significant decreases in the mRNA levels of Hes1 and [Notch1] but had no effects on the levels of MAML1 , p53 or HPV E6/E7 . Positive_regulation NOTCH1 MAML3 21640102 2446208 Furthermore , increased level of cleaved [Notch1] was *detected* when was expressed . Positive_regulation NOTCH1 MAML3 22069191 2504259 Mastermind-like 1 (MamL1) and are *essential* for [Notch] signaling in vivo . Positive_regulation NOTCH1 MAML3 23293291 2725488 transcriptional co-activator *mediated* [Notch] signaling is indispensable for maintaining conjunctival epithelial identity . Positive_regulation NOTCH1 NR2F1 16914494 1608516 Thus , we present evidence that reduced Notch signaling contributes to increases in hair cell and support cell differentiation in COUP-TFI ( -/- ) mice , and suggest that is *required* for [Notch] regulation of hair cell and support cell differentiation . Positive_regulation NOTCH1 NRARP 16228014 1489375 These findings reveal that independently *regulates* canonical Wnt and [Notch] signalling by modulating LEF1 and Notch protein turnover , respectively . Positive_regulation NOTCH1 PGC 24506866 2914228 Mechanistically , *induces* [Notch] signaling , blunts activation of Rac/Akt/eNOS signaling , and renders endothelial cells unresponsive to established angiogenic factors . Positive_regulation NOTCH1 RNF150 11740941 887162 [Notch] signaling in Drosophila *requires* a encoded by neuralized . Positive_regulation NOTCH1 TLR7 18085664 1847289 [Notch] signaling is *activated* by stimulation and regulates macrophage functions . Positive_regulation NOTCH1 TLR7 18976936 1989478 This Hes1- and Hey1 mediated feedback inhibitory loop was abrogated by interferon-gamma (IFN-gamma) , which blocked *induced* activation of canonical [Notch] target genes by inhibiting Notch2 signaling and downstream transcription . Positive_regulation NOTCH1 TLR7 22205705 2558827 It is widely accepted that signaling can *activate* [Notch] pathway ; Positive_regulation NOTCH1 TNF 14586405 1159561 We found that *induced* the expression of [Notch-1] , Notch-4 , and Jagged-2 in RSF . Positive_regulation NOTCH1 TNF 21593384 2441525 With regard to pDCs , [Notch] activation *induced* whereas Notch inhibition significantly abrogated the secretion of CCL19 , CXCL9 , CXCL10 , and TNF-a . Positive_regulation NOTCH1 TNF 23938602 2845162 , a major inflammatory cytokine , significantly *activated* [Notch] signaling in vitro . Positive_regulation NOTCH2 CDKN1C 16033893 1436233 Here , we report that , in zebrafish , expression of the Cdki gene cyclin dependent kinase inhibitor 1c ( cdkn1c ) , a p57 homolog , is negatively regulated by [Delta-Notch] signaling and that function is *required* for neural plate cells to stop dividing and differentiate as neurons on schedule , even in the absence of Notch signaling activity . Positive_regulation NOTCH2 HBEGF 24188029 2921120 RT-qPCR analysis demonstrated that HB-EGF affected the expression of Notch signaling pathway genes , implying a role for the [Notch] signaling in *mediated* astrocyte response . Positive_regulation NOTCH2 HES2 16682003 1559641 Hrt and negatively *regulate* [Notch] signaling through interactions with RBP-Jkappa . Positive_regulation NOTCH2 JAG1 10958687 726169 Binding of Delta1 , , and Jagged2 to Notch2 rapidly *induces* cleavage , nuclear translocation , and hyperphosphorylation of [Notch2] . Positive_regulation NOTCH2 JAG1 11707585 879627 Fringe modulation of *induced* [Notch] signaling requires the action of beta 4galactosyltransferase-1 . Positive_regulation NOTCH2 JAG1 11707585 879631 Although the beta 3GlcNAcT activity of manic or lunatic fringe is shown to be necessary for inhibition of *induced* [Notch] signaling in a coculture assay , it is not sufficient . Positive_regulation NOTCH2 JAG1 12370358 995875 Our data suggest that *activation* of [Notch] by plays an important role in maturation of human DCs . Positive_regulation NOTCH2 JAG1 12417415 1012995 Interestingly , addition of a beta1,4 galactose by beta4GalT-1 to the GlcNAc added by fringe is required for *induced* [Notch] signaling to be inhibited in a co-culture assay . Positive_regulation NOTCH2 JAG1 14726396 1234980 *induced* [Notch] signaling drives proliferation of multiple myeloma cells . Positive_regulation NOTCH2 JAG1 15192074 1288763 Treatment with 17 beta-estradiol also led to an activation of Notch signaling in MCF7 cells expressing Notch1 reporter gene or by promoting *induced* [Notch] signaling in coculture assays . Positive_regulation NOTCH2 JAG1 15550486 1374893 *dependent* [Notch] signaling is dispensable for hematopoietic stem cell self-renewal and differentiation . Positive_regulation NOTCH2 JAG1 15550486 1374897 In contrast to earlier reports , these data exclude an essential role for *mediated* [Notch] signaling during hematopoiesis . Positive_regulation NOTCH2 JAG1 16023595 1435207 Here , we report that the Notch ligand induced by growth factors via mitogen activating protein kinase (MAPK) in head and neck squamous cell carcinoma ( HNSCC ) cells *triggered* [Notch] activation in neighboring endothelial cells ( ECs ) and promoted capillary-like sprout formation . Positive_regulation NOTCH2 JAG1 16571776 1555921 Here , we show that activation of the Notch pathway by either *stimulation* of cell surface [Notch] receptors with crosslinked soluble delta-like 4 ( sDll4 ) ( sJag1 ) or constitutive expression of the Notch1 intracellular domain ( N ( IC ) ) suppresses endothelial cell proliferation . Positive_regulation NOTCH2 JAG1 16865239 1592718 NUMB inhibits Notch signaling in progenitor cells to induce differentiation , while *activates* [Notch] signaling in stem cells to maintain self-renewal potential . Positive_regulation NOTCH2 JAG1 16867989 1613515 Physiological [Notch] *stimulation* by its ligand , but not Dll4 , directly induces Sm-mhc expression in 10T1/2 cells without de novo protein synthesis , indicative of a ligand-selective effect . Positive_regulation NOTCH2 JAG1 17003479 1618619 *Stimulation* of [Notch] by its ligand diminished the proliferation of cultured metaplastic exocrine cells . Positive_regulation NOTCH2 JAG1 17259973 1696714 Conversely , *activation* of [Notch] by a soluble peptide leads to fewer tip cells and vessel branches . Positive_regulation NOTCH2 JAG1 17475842 1738423 In the present report we demonstrate that *induced* [Notch] signaling ( using immobilized Jagged-1 fusion protein ) during stimulation of purified human CD4+ and CD8+ T cells potently inhibits T cell proliferation and effector function , including both Th1- and Th2 associated cytokines . Positive_regulation NOTCH2 JAG1 17568183 1815811 and JAG2 *activate* [Notch] signaling , while DKK1 and SFRP1 inhibit WNT signaling . Positive_regulation NOTCH2 JAG1 17652726 1776206 The *activation* of [Notch] by resulted in the upregulation of active forms of Notch1 and 2 proteins ( P < 0.05 ) , with a concurrent increase in Ki67 ( P < 0.05 ) and a decrease in CK3 ( P < 0.05 ) expression . Positive_regulation NOTCH2 JAG1 17967789 1826519 Likewise , *stimulation* of [Notch] signaling by immobilized promoted Wnt5a expression in EPCs . Positive_regulation NOTCH2 JAG1 17984306 1826751 mediated [Notch] *activation* induces epithelial-to-mesenchymal transition through Slug induced repression of E-cadherin . Positive_regulation NOTCH2 JAG1 18256896 1884760 [Notch] *activation* by the and Delta-like 4 ligands regulates different steps of blood vessel development ranging from proliferation and survival of endothelial cells , to vessel branching and arterial-venous differentiation . Positive_regulation NOTCH2 JAG1 18347015 1905814 Nevertheless , they have reduced binding of Notch ligands and low levels of Delta1- and *induced* [Notch] signaling . Positive_regulation NOTCH2 JAG1 18445292 1915681 In an ES cell co-culture assay , [Notch] signaling *induced* by or Delta1 was reduced to a similar level in Notch1 ( lbd ) and Notch1 null cells . Positive_regulation NOTCH2 JAG1 18495362 1921846 *Stimulation* of [Notch] receptors by exposure of mouse cortical neurons to the Notch ligand resulted in increased microtubule stability , as measured by using antibodies against post-translationally modified alpha tubulin , and changes in axonal morphology and branching , with varicosity loss , thicker neurites and enlarged growth cones . Positive_regulation NOTCH2 JAG1 18710934 1968165 In contrast , *induction* of [Notch] signaling by or by ectopic expression of intracellular Notch2 enhances NFATc1 promoter activity and expression and promotes osteoclastogenesis . Positive_regulation NOTCH2 JAG1 19524514 2092998 Upon glycosylation of Notch , [Dll4-Notch] signaling is *enhanced* , whereas has weak signaling capacity and competes with Dll4 . Positive_regulation NOTCH2 JAG1 19598246 2149799 Recently , another Notch ligand , dependent [Notch] *activation* , has been revealed to be important for the determination of the prosensory region in the earlier stage before cell differentiation . Positive_regulation NOTCH2 JAG1 19915977 2287040 Cyclin D1 is a direct target of *mediated* [Notch] signaling in breast cancer . Positive_regulation NOTCH2 JAG1 19915977 2287049 We show that down-regulation *reduces* direct binding of [Notch] to the cyclin D1 promoter , reduced cyclin D1 expression and inhibition of cell cycle progression through the cyclin D1-dependant G1/S checkpoint . Positive_regulation NOTCH2 JAG1 19935714 2210111 In the human HT29Cl16E colonic carcinoma cell line , induction of goblet cell differentiation by contact inhibition of growth depended on the loss of mediated [Notch] *activation* , with signaling through Notch1 and Notch2 acting redundantly . Positive_regulation NOTCH2 JAG1 20010940 2191381 Epithelial-to-mesenchymal transition is mediated , in part , by two transcription repressors , Snail and Slug , that are known to be targets of the Notch signaling pathway , and *induced* [Notch] activation increases EMT . Positive_regulation NOTCH2 JAG1 20081190 2194401 Fng proteins enhance Dll1 activated Notch signalling and block [Notch] activation *mediated* by . Positive_regulation NOTCH2 JAG1 20157766 2272312 could *activate* [Notch] signaling in the human promyelocytic leukemia cell line HL60 , as shown by a reporter assay and the induced expression of Notch effector gene Hes1 and Hes5 . Positive_regulation NOTCH2 JAG1 20428807 2247369 [Notch] is *activated* by DLL and presents on neighboring cells . Positive_regulation NOTCH2 JAG1 20510365 2289456 In vivo overexpression experiments with Notch ligands suggest that Lfng strongly augments [Notch] signaling *mediated* by Delta-like 1 but not . Positive_regulation NOTCH2 JAG1 20602435 2309651 While *induced* minimal [Notch] signaling , Jagged2 elicited substantial levels of Hes1 transcripts and promoted T lymphopoiesis in vitro . Positive_regulation NOTCH2 JAG1 20837470 2342403 In CHO cells with low levels of Slc35c2 , both Delta1- and *induced* [Notch] signaling were reduced , and the fucosylation of a Notch1 fragment was also decreased . Positive_regulation NOTCH2 JAG1 21124801 2355723 However , can only *activate* [Notch] signalling within the V1 and dI6 domains , whereas Dll1 can signal to neural progenitors both inside and outside its domains of expression . Positive_regulation NOTCH2 JAG1 21151194 2463389 Epithelial and stromal cell populations in the thymus express the Notch DSL ( Delta , Serrate and Lag2 ) ligands Delta-like 1 (Dll1) , Delta-like 4 (Dll4) , and Jagged 2 , and *induce* [Notch] signalling in thymocytes that express the Notch receptor . Positive_regulation NOTCH2 JAG1 21199807 2374290 These data suggest that induced [Notch] *activation* results in breast cancer progression through upregulation of the plasminogen activator system , directly linking these 2 important pathways of poor prognosis . Positive_regulation NOTCH2 JAG1 21685392 2465402 *Activation* of [Notch] signaling by in vascular smooth muscle cells ( VSMC ) promotes a differentiated phenotype characterized by increased expression of contractile proteins . Positive_regulation NOTCH2 JAG1 21685392 2465418 *Activation* of [Notch] receptors by caused CBF1 dependent up-regulation of miR-143/145 , increased differentiation , and decreased proliferation . Positive_regulation NOTCH2 JAG1 22081605 2528650 In mutant Chinese hamster ovary ( CHO ) cells that do not add galactose (Gal) to the GlcNAc transferred by Fringe , *induced* [NOTCH] signaling is not inhibited by LFNG or MFNG . Positive_regulation NOTCH2 JAG1 22147907 2536474 [Notch] *activation* of contributes to the assembly of the arterial wall . Positive_regulation NOTCH2 JAG1 22275127 2551533 Requirements for *mediated* [Notch] signaling during early mouse lens development . Positive_regulation NOTCH2 JAG1 22388089 2577111 In particular , we found that during biliary regeneration , expression of ( a Notch ligand ) by myofibroblasts *promoted* [Notch] signaling in HPCs and thus their biliary specification to cholangiocytes . Positive_regulation NOTCH2 JAG1 22427350 2588202 Analysis of clinical data indicates that Jag1 expression correlates with both grade and stage of ACCs , supporting a role of *dependent* [Notch] activation in late-stage ACCs . Positive_regulation NOTCH2 JAG1 22452482 2606752 Endothelial progenitor cells promote astrogliosis following spinal cord injury through *dependent* [Notch] signaling . Positive_regulation NOTCH2 JAG1 23046039 2689809 Moreover , also *increased* expression of [Notch] downstream genes and PPAR-? . Positive_regulation NOTCH2 JAG1 23116754 2751047 In the further experiments , down-regulation of Notch signaling was shown to be critical for BM-MSCs to differentiate into hepatocytes , as increased *resulted* in up-regulated [Notch] activation leading to higher levels of expression of Hes1 and Hey1 , which completely blocked Albumin expresion in BM-MSCs . Positive_regulation NOTCH2 JAG1 23526493 2782375 Our results demonstrate that *mediated* [Notch] signaling regulates multiple cell fate decisions as well as differentiation in the respiratory system to coordinate lung development and to maintain a balance of airway cell types in adult life . Positive_regulation NOTCH2 JAG1 23831026 2815972 We show that shedding of Jag1 is reduced in BACE1 null mice and upregulated *enhances* [Notch] signaling via cell-cell juxtacrine interactions . Positive_regulation NOTCH2 JAG1 23965337 2845531 Overexpression of S-phase kinase associated protein before [Notch] *activation* by suppressed the induction of p27 ( kip1 ) . Positive_regulation NOTCH2 JAG1 24115357 2896445 We show that the transplantation of hESC derived OPC and MP promotes astrogliosis , through activation of *dependent* [Notch] and Jak/STAT signaling that support axonal survival . Positive_regulation NOTCH2 JAG1 24140644 2868117 In conclusion , it seems that HCs fine-tune liver inflammation by upregulation of and *activation* of [Notch] signaling in Th1 cells . Positive_regulation NOTCH2 JAG1 24651014 2925934 In turn , upregulation of on ECs reciprocally *induces* [Notch2-Hey1] in LCs . Positive_regulation NOTCH2 JAG1 25309874 2959378 In fact , *stimulated* [Notch] activation is directly implicated in tumor growth through maintaining cancer stem cell populations , promoting cell survival , inhibiting apoptosis , and driving cell proliferation and metastasis . Positive_regulation NOTCH2 MAML3 16966428 1627809 These findings indicate that the Notch requirement during the beta-selection checkpoint in vivo is absolute and independent of the pre-TCR , and it depends on transcriptional *activation* by [Notch] via the complex . Positive_regulation NOTCH2 MAML3 21302306 2480162 We found that FGF1 export and expression are regulated through [Notch] signaling *mediated* by transcription factor CBF1 and its partner . Positive_regulation NOTCH2 MAML3 21640102 2446187 is *required* for stable formation of [Notch] transcriptional complexes at the promoters of Notch target genes . Positive_regulation NOTCH2 MAML3 22069191 2504261 Mastermind-like 1 (MamL1) and are *essential* for [Notch] signaling in vivo . Positive_regulation NOTCH2 MAML3 23293291 2725491 transcriptional co-activator *mediated* [Notch] signaling is indispensable for maintaining conjunctival epithelial identity . Positive_regulation NOTCH2 NR2F1 16914494 1608517 Thus , we present evidence that reduced Notch signaling contributes to increases in hair cell and support cell differentiation in COUP-TFI ( -/- ) mice , and suggest that is *required* for [Notch] regulation of hair cell and support cell differentiation . Positive_regulation NOTCH2 NRARP 16228014 1489376 These findings reveal that independently *regulates* canonical Wnt and [Notch] signalling by modulating LEF1 and Notch protein turnover , respectively . Positive_regulation NOTCH2 PGC 24506866 2914229 Mechanistically , *induces* [Notch] signaling , blunts activation of Rac/Akt/eNOS signaling , and renders endothelial cells unresponsive to established angiogenic factors . Positive_regulation NOTCH2 RNF150 11740941 887238 [Notch] signaling in Drosophila *requires* a encoded by neuralized . Positive_regulation NOTCH2 TLR7 18085664 1847299 [Notch] signaling is *activated* by stimulation and regulates macrophage functions . Positive_regulation NOTCH2 TLR7 18976936 1989488 This Hes1- and Hey1 mediated feedback inhibitory loop was abrogated by interferon-gamma (IFN-gamma) , which blocked *induced* activation of canonical [Notch] target genes by inhibiting Notch2 signaling and downstream transcription . Positive_regulation NOTCH2 TLR7 22205705 2558837 It is widely accepted that signaling can *activate* [Notch] pathway ; Positive_regulation NOTCH2 TNF 20011512 2175074 In conclusion , signaling *activates* [Notch2] that sensitizes ECs to apoptosis via modulation of the key apoptosis regulator survivin . Positive_regulation NOTCH2 TNF 21593384 2441526 With regard to pDCs , [Notch] activation *induced* whereas Notch inhibition significantly abrogated the secretion of CCL19 , CXCL9 , CXCL10 , and TNF-a . Positive_regulation NOTCH2 TNF 23938602 2845163 , a major inflammatory cytokine , significantly *activated* [Notch] signaling in vitro . Positive_regulation NOTCH3 CDKN1C 16033893 1436234 Here , we report that , in zebrafish , expression of the Cdki gene cyclin dependent kinase inhibitor 1c ( cdkn1c ) , a p57 homolog , is negatively regulated by [Delta-Notch] signaling and that function is *required* for neural plate cells to stop dividing and differentiate as neurons on schedule , even in the absence of Notch signaling activity . Positive_regulation NOTCH3 HBEGF 24188029 2921121 RT-qPCR analysis demonstrated that HB-EGF affected the expression of Notch signaling pathway genes , implying a role for the [Notch] signaling in *mediated* astrocyte response . Positive_regulation NOTCH3 HES2 16682003 1559648 Hrt and negatively *regulate* [Notch] signaling through interactions with RBP-Jkappa . Positive_regulation NOTCH3 JAG1 11707585 879628 Fringe modulation of *induced* [Notch] signaling requires the action of beta 4galactosyltransferase-1 . Positive_regulation NOTCH3 JAG1 11707585 879632 Although the beta 3GlcNAcT activity of manic or lunatic fringe is shown to be necessary for inhibition of *induced* [Notch] signaling in a coculture assay , it is not sufficient . Positive_regulation NOTCH3 JAG1 12370358 995876 Our data suggest that *activation* of [Notch] by plays an important role in maturation of human DCs . Positive_regulation NOTCH3 JAG1 12417415 1012996 Interestingly , addition of a beta1,4 galactose by beta4GalT-1 to the GlcNAc added by fringe is required for *induced* [Notch] signaling to be inhibited in a co-culture assay . Positive_regulation NOTCH3 JAG1 14726396 1234981 *induced* [Notch] signaling drives proliferation of multiple myeloma cells . Positive_regulation NOTCH3 JAG1 15192074 1288764 Treatment with 17 beta-estradiol also led to an activation of Notch signaling in MCF7 cells expressing Notch1 reporter gene or by promoting *induced* [Notch] signaling in coculture assays . Positive_regulation NOTCH3 JAG1 15550486 1374894 *dependent* [Notch] signaling is dispensable for hematopoietic stem cell self-renewal and differentiation . Positive_regulation NOTCH3 JAG1 15550486 1374898 In contrast to earlier reports , these data exclude an essential role for *mediated* [Notch] signaling during hematopoiesis . Positive_regulation NOTCH3 JAG1 16023595 1435208 Here , we report that the Notch ligand induced by growth factors via mitogen activating protein kinase (MAPK) in head and neck squamous cell carcinoma ( HNSCC ) cells *triggered* [Notch] activation in neighboring endothelial cells ( ECs ) and promoted capillary-like sprout formation . Positive_regulation NOTCH3 JAG1 16571776 1555922 Here , we show that activation of the Notch pathway by either *stimulation* of cell surface [Notch] receptors with crosslinked soluble delta-like 4 ( sDll4 ) ( sJag1 ) or constitutive expression of the Notch1 intracellular domain ( N ( IC ) ) suppresses endothelial cell proliferation . Positive_regulation NOTCH3 JAG1 16827154 1586605 These findings suggest that Notch3 may be involved in mechanisms controling the differentiation and the spread of HCC and that [Notch3] activation may be *dependent* on both and Delta 1 ligands . Positive_regulation NOTCH3 JAG1 16865239 1592719 NUMB inhibits Notch signaling in progenitor cells to induce differentiation , while *activates* [Notch] signaling in stem cells to maintain self-renewal potential . Positive_regulation NOTCH3 JAG1 16867989 1613517 Physiological [Notch] *stimulation* by its ligand , but not Dll4 , directly induces Sm-mhc expression in 10T1/2 cells without de novo protein synthesis , indicative of a ligand-selective effect . Positive_regulation NOTCH3 JAG1 17003479 1618620 *Stimulation* of [Notch] by its ligand diminished the proliferation of cultured metaplastic exocrine cells . Positive_regulation NOTCH3 JAG1 17259973 1696715 Conversely , *activation* of [Notch] by a soluble peptide leads to fewer tip cells and vessel branches . Positive_regulation NOTCH3 JAG1 17475842 1738424 In the present report we demonstrate that *induced* [Notch] signaling ( using immobilized Jagged-1 fusion protein ) during stimulation of purified human CD4+ and CD8+ T cells potently inhibits T cell proliferation and effector function , including both Th1- and Th2 associated cytokines . Positive_regulation NOTCH3 JAG1 17568183 1815813 and JAG2 *activate* [Notch] signaling , while DKK1 and SFRP1 inhibit WNT signaling . Positive_regulation NOTCH3 JAG1 17652726 1776207 The *activation* of [Notch] by resulted in the upregulation of active forms of Notch1 and 2 proteins ( P < 0.05 ) , with a concurrent increase in Ki67 ( P < 0.05 ) and a decrease in CK3 ( P < 0.05 ) expression . Positive_regulation NOTCH3 JAG1 17967789 1826520 Likewise , *stimulation* of [Notch] signaling by immobilized promoted Wnt5a expression in EPCs . Positive_regulation NOTCH3 JAG1 17984306 1826752 mediated [Notch] *activation* induces epithelial-to-mesenchymal transition through Slug induced repression of E-cadherin . Positive_regulation NOTCH3 JAG1 18256896 1884762 [Notch] *activation* by the and Delta-like 4 ligands regulates different steps of blood vessel development ranging from proliferation and survival of endothelial cells , to vessel branching and arterial-venous differentiation . Positive_regulation NOTCH3 JAG1 18347015 1905815 Nevertheless , they have reduced binding of Notch ligands and low levels of Delta1- and *induced* [Notch] signaling . Positive_regulation NOTCH3 JAG1 18445292 1915683 In an ES cell co-culture assay , [Notch] signaling *induced* by or Delta1 was reduced to a similar level in Notch1 ( lbd ) and Notch1 null cells . Positive_regulation NOTCH3 JAG1 18495362 1921847 *Stimulation* of [Notch] receptors by exposure of mouse cortical neurons to the Notch ligand resulted in increased microtubule stability , as measured by using antibodies against post-translationally modified alpha tubulin , and changes in axonal morphology and branching , with varicosity loss , thicker neurites and enlarged growth cones . Positive_regulation NOTCH3 JAG1 18710934 1968167 In contrast , *induction* of [Notch] signaling by or by ectopic expression of intracellular Notch2 enhances NFATc1 promoter activity and expression and promotes osteoclastogenesis . Positive_regulation NOTCH3 JAG1 18757425 1956572 In cell lines with the highest HEY1 induction , [NOTCH3] activation was the *consequence* of transcriptional induction . Positive_regulation NOTCH3 JAG1 19150886 2038048 Furthermore , in mural cells , a dominant negative Mastermind-like1 construct inhibited [NOTCH3] expression , and endothelial expressed was *required* for its induction . Positive_regulation NOTCH3 JAG1 19524514 2092999 Upon glycosylation of Notch , [Dll4-Notch] signaling is *enhanced* , whereas has weak signaling capacity and competes with Dll4 . Positive_regulation NOTCH3 JAG1 19598246 2149800 Recently , another Notch ligand , *dependent* [Notch] activation , has been revealed to be important for the determination of the prosensory region in the earlier stage before cell differentiation . Positive_regulation NOTCH3 JAG1 19915977 2287041 Cyclin D1 is a direct target of *mediated* [Notch] signaling in breast cancer . Positive_regulation NOTCH3 JAG1 19915977 2287050 We show that down-regulation *reduces* direct binding of [Notch] to the cyclin D1 promoter , reduced cyclin D1 expression and inhibition of cell cycle progression through the cyclin D1-dependant G1/S checkpoint . Positive_regulation NOTCH3 JAG1 19935714 2210112 In the human HT29Cl16E colonic carcinoma cell line , induction of goblet cell differentiation by contact inhibition of growth depended on the loss of mediated [Notch] *activation* , with signaling through Notch1 and Notch2 acting redundantly . Positive_regulation NOTCH3 JAG1 20010940 2191382 Epithelial-to-mesenchymal transition is mediated , in part , by two transcription repressors , Snail and Slug , that are known to be targets of the Notch signaling pathway , and induced [Notch] *activation* increases EMT . Positive_regulation NOTCH3 JAG1 20081190 2194402 Fng proteins enhance Dll1 activated Notch signalling and block [Notch] activation *mediated* by . Positive_regulation NOTCH3 JAG1 20157766 2272314 could *activate* [Notch] signaling in the human promyelocytic leukemia cell line HL60 , as shown by a reporter assay and the induced expression of Notch effector gene Hes1 and Hes5 . Positive_regulation NOTCH3 JAG1 20428807 2247374 [Notch] is *activated* by DLL and presents on neighboring cells . Positive_regulation NOTCH3 JAG1 20510365 2289459 In vivo overexpression experiments with Notch ligands suggest that Lfng strongly augments [Notch] signaling *mediated* by Delta-like 1 but not . Positive_regulation NOTCH3 JAG1 20602435 2309652 While *induced* minimal [Notch] signaling , Jagged2 elicited substantial levels of Hes1 transcripts and promoted T lymphopoiesis in vitro . Positive_regulation NOTCH3 JAG1 20837470 2342404 In CHO cells with low levels of Slc35c2 , both Delta1- and *induced* [Notch] signaling were reduced , and the fucosylation of a Notch1 fragment was also decreased . Positive_regulation NOTCH3 JAG1 21124801 2355724 However , can only *activate* [Notch] signalling within the V1 and dI6 domains , whereas Dll1 can signal to neural progenitors both inside and outside its domains of expression . Positive_regulation NOTCH3 JAG1 21151194 2463392 Epithelial and stromal cell populations in the thymus express the Notch DSL ( Delta , Serrate and Lag2 ) ligands Delta-like 1 (Dll1) , Delta-like 4 (Dll4) , and Jagged 2 , and *induce* [Notch] signalling in thymocytes that express the Notch receptor . Positive_regulation NOTCH3 JAG1 21199807 2374291 These data suggest that *induced* [Notch] activation results in breast cancer progression through upregulation of the plasminogen activator system , directly linking these 2 important pathways of poor prognosis . Positive_regulation NOTCH3 JAG1 21685392 2465403 *Activation* of [Notch] signaling by in vascular smooth muscle cells ( VSMC ) promotes a differentiated phenotype characterized by increased expression of contractile proteins . Positive_regulation NOTCH3 JAG1 21685392 2465419 *Activation* of [Notch] receptors by caused CBF1 dependent up-regulation of miR-143/145 , increased differentiation , and decreased proliferation . Positive_regulation NOTCH3 JAG1 22081605 2528651 In mutant Chinese hamster ovary ( CHO ) cells that do not add galactose (Gal) to the GlcNAc transferred by Fringe , *induced* [NOTCH] signaling is not inhibited by LFNG or MFNG . Positive_regulation NOTCH3 JAG1 22147907 2536475 [Notch] *activation* of contributes to the assembly of the arterial wall . Positive_regulation NOTCH3 JAG1 22275127 2551535 Requirements for *mediated* [Notch] signaling during early mouse lens development . Positive_regulation NOTCH3 JAG1 22388089 2577112 In particular , we found that during biliary regeneration , expression of ( a Notch ligand ) by myofibroblasts *promoted* [Notch] signaling in HPCs and thus their biliary specification to cholangiocytes . Positive_regulation NOTCH3 JAG1 22427350 2588203 Analysis of clinical data indicates that Jag1 expression correlates with both grade and stage of ACCs , supporting a role of dependent [Notch] *activation* in late-stage ACCs . Positive_regulation NOTCH3 JAG1 22452482 2606753 Endothelial progenitor cells promote astrogliosis following spinal cord injury through *dependent* [Notch] signaling . Positive_regulation NOTCH3 JAG1 23046039 2689810 Moreover , also *increased* expression of [Notch] downstream genes and PPAR-? . Positive_regulation NOTCH3 JAG1 23116754 2751048 In the further experiments , down-regulation of Notch signaling was shown to be critical for BM-MSCs to differentiate into hepatocytes , as increased *resulted* in up-regulated [Notch] activation leading to higher levels of expression of Hes1 and Hey1 , which completely blocked Albumin expresion in BM-MSCs . Positive_regulation NOTCH3 JAG1 23526493 2782376 Our results demonstrate that *mediated* [Notch] signaling regulates multiple cell fate decisions as well as differentiation in the respiratory system to coordinate lung development and to maintain a balance of airway cell types in adult life . Positive_regulation NOTCH3 JAG1 23831026 2815973 We show that shedding of Jag1 is reduced in BACE1 null mice and upregulated *enhances* [Notch] signaling via cell-cell juxtacrine interactions . Positive_regulation NOTCH3 JAG1 23965337 2845532 Overexpression of S-phase kinase associated protein before [Notch] *activation* by suppressed the induction of p27 ( kip1 ) . Positive_regulation NOTCH3 JAG1 24115357 2896446 We show that the transplantation of hESC derived OPC and MP promotes astrogliosis , through activation of *dependent* [Notch] and Jak/STAT signaling that support axonal survival . Positive_regulation NOTCH3 JAG1 24140644 2868118 In conclusion , it seems that HCs fine-tune liver inflammation by upregulation of and *activation* of [Notch] signaling in Th1 cells . Positive_regulation NOTCH3 JAG1 25309874 2959379 In fact , *stimulated* [Notch] activation is directly implicated in tumor growth through maintaining cancer stem cell populations , promoting cell survival , inhibiting apoptosis , and driving cell proliferation and metastasis . Positive_regulation NOTCH3 MAML3 16966428 1627813 These findings indicate that the Notch requirement during the beta-selection checkpoint in vivo is absolute and independent of the pre-TCR , and it depends on transcriptional *activation* by [Notch] via the complex . Positive_regulation NOTCH3 MAML3 21302306 2480166 We found that FGF1 export and expression are regulated through [Notch] signaling *mediated* by transcription factor CBF1 and its partner . Positive_regulation NOTCH3 MAML3 21640102 2446190 is *required* for stable formation of [Notch] transcriptional complexes at the promoters of Notch target genes . Positive_regulation NOTCH3 MAML3 22069191 2504263 Mastermind-like 1 (MamL1) and are *essential* for [Notch] signaling in vivo . Positive_regulation NOTCH3 MAML3 23293291 2725494 transcriptional co-activator *mediated* [Notch] signaling is indispensable for maintaining conjunctival epithelial identity . Positive_regulation NOTCH3 NR2F1 16914494 1608518 Thus , we present evidence that reduced Notch signaling contributes to increases in hair cell and support cell differentiation in COUP-TFI ( -/- ) mice , and suggest that is *required* for [Notch] regulation of hair cell and support cell differentiation . Positive_regulation NOTCH3 NRARP 16228014 1489377 These findings reveal that independently *regulates* canonical Wnt and [Notch] signalling by modulating LEF1 and Notch protein turnover , respectively . Positive_regulation NOTCH3 PGC 24506866 2914230 Mechanistically , *induces* [Notch] signaling , blunts activation of Rac/Akt/eNOS signaling , and renders endothelial cells unresponsive to established angiogenic factors . Positive_regulation NOTCH3 RNF150 11740941 887314 [Notch] signaling in Drosophila *requires* a encoded by neuralized . Positive_regulation NOTCH3 TLR7 18085664 1847309 [Notch] signaling is *activated* by stimulation and regulates macrophage functions . Positive_regulation NOTCH3 TLR7 18976936 1989498 This Hes1- and Hey1 mediated feedback inhibitory loop was abrogated by interferon-gamma (IFN-gamma) , which blocked *induced* activation of canonical [Notch] target genes by inhibiting Notch2 signaling and downstream transcription . Positive_regulation NOTCH3 TLR7 22205705 2558847 It is widely accepted that signaling can *activate* [Notch] pathway ; Positive_regulation NOTCH3 TNF 21593384 2441527 With regard to pDCs , [Notch] activation *induced* whereas Notch inhibition significantly abrogated the secretion of CCL19 , CXCL9 , CXCL10 , and TNF-a . Positive_regulation NOTCH3 TNF 23938602 2845164 , a major inflammatory cytokine , significantly *activated* [Notch] signaling in vitro . Positive_regulation NOTCH4 CDKN1C 16033893 1436235 Here , we report that , in zebrafish , expression of the Cdki gene cyclin dependent kinase inhibitor 1c ( cdkn1c ) , a p57 homolog , is negatively regulated by [Delta-Notch] signaling and that function is *required* for neural plate cells to stop dividing and differentiate as neurons on schedule , even in the absence of Notch signaling activity . Positive_regulation NOTCH4 HBEGF 24188029 2921122 RT-qPCR analysis demonstrated that HB-EGF affected the expression of Notch signaling pathway genes , implying a role for the [Notch] signaling in *mediated* astrocyte response . Positive_regulation NOTCH4 HES2 16682003 1559655 Hrt and negatively *regulate* [Notch] signaling through interactions with RBP-Jkappa . Positive_regulation NOTCH4 JAG1 11707585 879629 Fringe modulation of *induced* [Notch] signaling requires the action of beta 4galactosyltransferase-1 . Positive_regulation NOTCH4 JAG1 11707585 879633 Although the beta 3GlcNAcT activity of manic or lunatic fringe is shown to be necessary for inhibition of *induced* [Notch] signaling in a coculture assay , it is not sufficient . Positive_regulation NOTCH4 JAG1 12370358 995877 Our data suggest that *activation* of [Notch] by plays an important role in maturation of human DCs . Positive_regulation NOTCH4 JAG1 12417415 1012997 Interestingly , addition of a beta1,4 galactose by beta4GalT-1 to the GlcNAc added by fringe is required for *induced* [Notch] signaling to be inhibited in a co-culture assay . Positive_regulation NOTCH4 JAG1 14726396 1234982 *induced* [Notch] signaling drives proliferation of multiple myeloma cells . Positive_regulation NOTCH4 JAG1 15192074 1288765 Treatment with 17 beta-estradiol also led to an activation of Notch signaling in MCF7 cells expressing Notch1 reporter gene or by promoting *induced* [Notch] signaling in coculture assays . Positive_regulation NOTCH4 JAG1 15550486 1374895 *dependent* [Notch] signaling is dispensable for hematopoietic stem cell self-renewal and differentiation . Positive_regulation NOTCH4 JAG1 15550486 1374899 In contrast to earlier reports , these data exclude an essential role for *mediated* [Notch] signaling during hematopoiesis . Positive_regulation NOTCH4 JAG1 16023595 1435209 Here , we report that the Notch ligand induced by growth factors via mitogen activating protein kinase (MAPK) in head and neck squamous cell carcinoma ( HNSCC ) cells *triggered* [Notch] activation in neighboring endothelial cells ( ECs ) and promoted capillary-like sprout formation . Positive_regulation NOTCH4 JAG1 16571776 1555923 Here , we show that activation of the Notch pathway by either *stimulation* of cell surface [Notch] receptors with crosslinked soluble delta-like 4 ( sDll4 ) ( sJag1 ) or constitutive expression of the Notch1 intracellular domain ( N ( IC ) ) suppresses endothelial cell proliferation . Positive_regulation NOTCH4 JAG1 16865239 1592720 NUMB inhibits Notch signaling in progenitor cells to induce differentiation , while *activates* [Notch] signaling in stem cells to maintain self-renewal potential . Positive_regulation NOTCH4 JAG1 16867989 1613519 Physiological [Notch] *stimulation* by its ligand , but not Dll4 , directly induces Sm-mhc expression in 10T1/2 cells without de novo protein synthesis , indicative of a ligand-selective effect . Positive_regulation NOTCH4 JAG1 17003479 1618621 *Stimulation* of [Notch] by its ligand diminished the proliferation of cultured metaplastic exocrine cells . Positive_regulation NOTCH4 JAG1 17259973 1696716 Conversely , *activation* of [Notch] by a soluble peptide leads to fewer tip cells and vessel branches . Positive_regulation NOTCH4 JAG1 17475842 1738425 In the present report we demonstrate that *induced* [Notch] signaling ( using immobilized Jagged-1 fusion protein ) during stimulation of purified human CD4+ and CD8+ T cells potently inhibits T cell proliferation and effector function , including both Th1- and Th2 associated cytokines . Positive_regulation NOTCH4 JAG1 17568183 1815815 and JAG2 *activate* [Notch] signaling , while DKK1 and SFRP1 inhibit WNT signaling . Positive_regulation NOTCH4 JAG1 17652726 1776208 The *activation* of [Notch] by resulted in the upregulation of active forms of Notch1 and 2 proteins ( P < 0.05 ) , with a concurrent increase in Ki67 ( P < 0.05 ) and a decrease in CK3 ( P < 0.05 ) expression . Positive_regulation NOTCH4 JAG1 17967789 1826521 Likewise , *stimulation* of [Notch] signaling by immobilized promoted Wnt5a expression in EPCs . Positive_regulation NOTCH4 JAG1 17984306 1826753 mediated [Notch] *activation* induces epithelial-to-mesenchymal transition through Slug induced repression of E-cadherin . Positive_regulation NOTCH4 JAG1 18256896 1884764 [Notch] *activation* by the and Delta-like 4 ligands regulates different steps of blood vessel development ranging from proliferation and survival of endothelial cells , to vessel branching and arterial-venous differentiation . Positive_regulation NOTCH4 JAG1 18347015 1905816 Nevertheless , they have reduced binding of Notch ligands and low levels of Delta1- and *induced* [Notch] signaling . Positive_regulation NOTCH4 JAG1 18445292 1915685 In an ES cell co-culture assay , [Notch] signaling *induced* by or Delta1 was reduced to a similar level in Notch1 ( lbd ) and Notch1 null cells . Positive_regulation NOTCH4 JAG1 18495362 1921848 *Stimulation* of [Notch] receptors by exposure of mouse cortical neurons to the Notch ligand resulted in increased microtubule stability , as measured by using antibodies against post-translationally modified alpha tubulin , and changes in axonal morphology and branching , with varicosity loss , thicker neurites and enlarged growth cones . Positive_regulation NOTCH4 JAG1 18710934 1968169 In contrast , *induction* of [Notch] signaling by or by ectopic expression of intracellular Notch2 enhances NFATc1 promoter activity and expression and promotes osteoclastogenesis . Positive_regulation NOTCH4 JAG1 19524514 2093000 Upon glycosylation of Notch , [Dll4-Notch] signaling is *enhanced* , whereas has weak signaling capacity and competes with Dll4 . Positive_regulation NOTCH4 JAG1 19598246 2149801 Recently , another Notch ligand , *dependent* [Notch] activation , has been revealed to be important for the determination of the prosensory region in the earlier stage before cell differentiation . Positive_regulation NOTCH4 JAG1 19915977 2287042 Cyclin D1 is a direct target of *mediated* [Notch] signaling in breast cancer . Positive_regulation NOTCH4 JAG1 19915977 2287051 We show that down-regulation *reduces* direct binding of [Notch] to the cyclin D1 promoter , reduced cyclin D1 expression and inhibition of cell cycle progression through the cyclin D1-dependant G1/S checkpoint . Positive_regulation NOTCH4 JAG1 19935714 2210113 In the human HT29Cl16E colonic carcinoma cell line , induction of goblet cell differentiation by contact inhibition of growth depended on the loss of mediated [Notch] *activation* , with signaling through Notch1 and Notch2 acting redundantly . Positive_regulation NOTCH4 JAG1 20010940 2191383 Epithelial-to-mesenchymal transition is mediated , in part , by two transcription repressors , Snail and Slug , that are known to be targets of the Notch signaling pathway , and *induced* [Notch] activation increases EMT . Positive_regulation NOTCH4 JAG1 20081190 2194403 Fng proteins enhance Dll1 activated Notch signalling and block [Notch] activation *mediated* by . Positive_regulation NOTCH4 JAG1 20157766 2272316 could *activate* [Notch] signaling in the human promyelocytic leukemia cell line HL60 , as shown by a reporter assay and the induced expression of Notch effector gene Hes1 and Hes5 . Positive_regulation NOTCH4 JAG1 20428807 2247379 [Notch] is *activated* by DLL and presents on neighboring cells . Positive_regulation NOTCH4 JAG1 20510365 2289462 In vivo overexpression experiments with Notch ligands suggest that Lfng strongly augments [Notch] signaling *mediated* by Delta-like 1 but not . Positive_regulation NOTCH4 JAG1 20602435 2309653 While *induced* minimal [Notch] signaling , Jagged2 elicited substantial levels of Hes1 transcripts and promoted T lymphopoiesis in vitro . Positive_regulation NOTCH4 JAG1 20837470 2342405 In CHO cells with low levels of Slc35c2 , both Delta1- and *induced* [Notch] signaling were reduced , and the fucosylation of a Notch1 fragment was also decreased . Positive_regulation NOTCH4 JAG1 21124801 2355725 However , can only *activate* [Notch] signalling within the V1 and dI6 domains , whereas Dll1 can signal to neural progenitors both inside and outside its domains of expression . Positive_regulation NOTCH4 JAG1 21151194 2463395 Epithelial and stromal cell populations in the thymus express the Notch DSL ( Delta , Serrate and Lag2 ) ligands Delta-like 1 (Dll1) , Delta-like 4 (Dll4) , and Jagged 2 , and *induce* [Notch] signalling in thymocytes that express the Notch receptor . Positive_regulation NOTCH4 JAG1 21199807 2374292 These data suggest that induced [Notch] *activation* results in breast cancer progression through upregulation of the plasminogen activator system , directly linking these 2 important pathways of poor prognosis . Positive_regulation NOTCH4 JAG1 21685392 2465404 *Activation* of [Notch] signaling by in vascular smooth muscle cells ( VSMC ) promotes a differentiated phenotype characterized by increased expression of contractile proteins . Positive_regulation NOTCH4 JAG1 21685392 2465420 *Activation* of [Notch] receptors by caused CBF1 dependent up-regulation of miR-143/145 , increased differentiation , and decreased proliferation . Positive_regulation NOTCH4 JAG1 22081605 2528652 In mutant Chinese hamster ovary ( CHO ) cells that do not add galactose (Gal) to the GlcNAc transferred by Fringe , *induced* [NOTCH] signaling is not inhibited by LFNG or MFNG . Positive_regulation NOTCH4 JAG1 22147907 2536476 [Notch] *activation* of contributes to the assembly of the arterial wall . Positive_regulation NOTCH4 JAG1 22275127 2551537 Requirements for *mediated* [Notch] signaling during early mouse lens development . Positive_regulation NOTCH4 JAG1 22388089 2577113 In particular , we found that during biliary regeneration , expression of ( a Notch ligand ) by myofibroblasts *promoted* [Notch] signaling in HPCs and thus their biliary specification to cholangiocytes . Positive_regulation NOTCH4 JAG1 22427350 2588204 Analysis of clinical data indicates that Jag1 expression correlates with both grade and stage of ACCs , supporting a role of *dependent* [Notch] activation in late-stage ACCs . Positive_regulation NOTCH4 JAG1 22452482 2606754 Endothelial progenitor cells promote astrogliosis following spinal cord injury through *dependent* [Notch] signaling . Positive_regulation NOTCH4 JAG1 23046039 2689811 Moreover , also *increased* expression of [Notch] downstream genes and PPAR-? . Positive_regulation NOTCH4 JAG1 23116754 2751049 In the further experiments , down-regulation of Notch signaling was shown to be critical for BM-MSCs to differentiate into hepatocytes , as increased *resulted* in up-regulated [Notch] activation leading to higher levels of expression of Hes1 and Hey1 , which completely blocked Albumin expresion in BM-MSCs . Positive_regulation NOTCH4 JAG1 23526493 2782377 Our results demonstrate that *mediated* [Notch] signaling regulates multiple cell fate decisions as well as differentiation in the respiratory system to coordinate lung development and to maintain a balance of airway cell types in adult life . Positive_regulation NOTCH4 JAG1 23831026 2815974 We show that shedding of Jag1 is reduced in BACE1 null mice and upregulated *enhances* [Notch] signaling via cell-cell juxtacrine interactions . Positive_regulation NOTCH4 JAG1 23965337 2845533 Overexpression of S-phase kinase associated protein before [Notch] *activation* by suppressed the induction of p27 ( kip1 ) . Positive_regulation NOTCH4 JAG1 24115357 2896447 We show that the transplantation of hESC derived OPC and MP promotes astrogliosis , through activation of *dependent* [Notch] and Jak/STAT signaling that support axonal survival . Positive_regulation NOTCH4 JAG1 24140644 2868119 In conclusion , it seems that HCs fine-tune liver inflammation by upregulation of and *activation* of [Notch] signaling in Th1 cells . Positive_regulation NOTCH4 JAG1 25309874 2959380 In fact , *stimulated* [Notch] activation is directly implicated in tumor growth through maintaining cancer stem cell populations , promoting cell survival , inhibiting apoptosis , and driving cell proliferation and metastasis . Positive_regulation NOTCH4 MAML3 16966428 1627817 These findings indicate that the Notch requirement during the beta-selection checkpoint in vivo is absolute and independent of the pre-TCR , and it depends on transcriptional *activation* by [Notch] via the complex . Positive_regulation NOTCH4 MAML3 21302306 2480170 We found that FGF1 export and expression are regulated through [Notch] signaling *mediated* by transcription factor CBF1 and its partner . Positive_regulation NOTCH4 MAML3 21640102 2446193 is *required* for stable formation of [Notch] transcriptional complexes at the promoters of Notch target genes . Positive_regulation NOTCH4 MAML3 22069191 2504265 Mastermind-like 1 (MamL1) and are *essential* for [Notch] signaling in vivo . Positive_regulation NOTCH4 MAML3 23293291 2725497 transcriptional co-activator *mediated* [Notch] signaling is indispensable for maintaining conjunctival epithelial identity . Positive_regulation NOTCH4 NR2F1 16914494 1608519 Thus , we present evidence that reduced Notch signaling contributes to increases in hair cell and support cell differentiation in COUP-TFI ( -/- ) mice , and suggest that is *required* for [Notch] regulation of hair cell and support cell differentiation . Positive_regulation NOTCH4 NRARP 16228014 1489378 These findings reveal that independently *regulates* canonical Wnt and [Notch] signalling by modulating LEF1 and Notch protein turnover , respectively . Positive_regulation NOTCH4 PGC 24506866 2914231 Mechanistically , *induces* [Notch] signaling , blunts activation of Rac/Akt/eNOS signaling , and renders endothelial cells unresponsive to established angiogenic factors . Positive_regulation NOTCH4 RNF150 11740941 887390 [Notch] signaling in Drosophila *requires* a encoded by neuralized . Positive_regulation NOTCH4 TLR7 18085664 1847319 [Notch] signaling is *activated* by stimulation and regulates macrophage functions . Positive_regulation NOTCH4 TLR7 18976936 1989508 This Hes1- and Hey1 mediated feedback inhibitory loop was abrogated by interferon-gamma (IFN-gamma) , which blocked *induced* activation of canonical [Notch] target genes by inhibiting Notch2 signaling and downstream transcription . Positive_regulation NOTCH4 TLR7 22205705 2558857 It is widely accepted that signaling can *activate* [Notch] pathway ; Positive_regulation NOTCH4 TNF 14586405 1159562 We found that *induced* the expression of Notch-1 , [Notch-4] , and Jagged-2 in RSF . Positive_regulation NOTCH4 TNF 18802018 1986929 We found that inhibition of Notch activity , reflected by both a reduced CBF1 activity and Hes1 expression , parallels the downregulation of [Notch4] expression *mediated* by in ECs . Positive_regulation NOTCH4 TNF 21593384 2441528 With regard to pDCs , [Notch] activation *induced* whereas Notch inhibition significantly abrogated the secretion of CCL19 , CXCL9 , CXCL10 , and TNF-a . Positive_regulation NOTCH4 TNF 23938602 2845165 , a major inflammatory cytokine , significantly *activated* [Notch] signaling in vitro . Positive_regulation NOV CTGF 21748432 2546609 We further found that adenoviral overexpression of *suppressed* [CCN3/NOV] expression , while the overexpression of CCN3/NOV as well as the suppression of CCN3/NOV by targeting siRNAs both resulted in enhanced CCN2/CTGF expression . Positive_regulation NOX1 ADRB2 19330844 2141811 activation *induces* microglial [NADPH oxidase] activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway . Positive_regulation NOX1 CAPN8 18950702 2014297 In conclusion , [NADPH oxidase] *induces* activation , leading to apoptosis in NE-induced cardiomyocytes . Positive_regulation NOX1 CTGF 16612258 1546601 CsA induced myocardial ANP and mRNA overexpression , RAS activation , [NADPH oxidase] *induction* , and NRF2 overexpression were prevented by LA . Positive_regulation NOX1 EPHB2 11211919 763856 These results suggest that the formation of F-actin is dependent on PI3-K and independent of PKC , ERK and p38 MAPK as well as the increase in intracellular Ca2+ , whereas the activation of [NADPH oxidase] is partly *dependent* on , p38 MAPK , Akt regulated by PI3-K , and strongly dependent on the activation of PKC and the increase in intracellular Ca2+ . Positive_regulation NOX1 EPHB2 15894894 1407894 These results suggest that either or p38 MAP-kinase are *involved* in the activation of both cPLA2 and [NADPH oxidase] , and that cPLA2 is required for activation of the NADPH oxidase by Ang II in human neutrophils . Positive_regulation NOX1 EPHB2 18573285 1959241 The subsequent response was increased ROS production associated with *activation* of [NADPH oxidase] ( NOX2 ) and then phosphorylation of MAP kinases ( , JNK ) . Positive_regulation NOX1 EPHB2 18638447 1947615 It was also reported that extracellular signal regulated kinase ( ) 1/2 is *involved* in the expression of [NOX1] . Positive_regulation NOX1 EPHB2 21660950 2442617 EGF induced downstream of FAK *requires* [rac1-NADPH oxidase] . Positive_regulation NOX1 FAS 15917250 1433512 These inhibitors and p47phox protein knockdown inhibited the early CD95L induced ROS response , suggesting that ceramide and PKCzeta are upstream events of the induced [Nox/Duox] *activation* . Positive_regulation NOX1 IL1B 10022882 590399 Reactive oxygen intermediate dependent NF-kappaB activation by *requires* 5-lipoxygenase or [NADPH oxidase] activity . Positive_regulation NOX1 IL1B 10086983 599680 After bilateral adrenalectomy , induced a smaller pressor response , but a larger *increase* in plasma [NOx] ; Positive_regulation NOX1 IL1B 10642306 660796 BEL inhibited *stimulated* [NOx] production and iNOS protein by 88 % and 93 % , respectively . Positive_regulation NOX1 IL1B 11880505 919469 In addition , we show that minocycline not only prevents MPTP induced activation of microglia but also the formation of mature and the *activation* of [NADPH-oxidase] and inducible nitric oxide synthase (iNOS) , three key microglial derived cytotoxic mediators . Positive_regulation NOX1 IL1B 14657615 1188528 Both and SNP *enhanced* [NOX] activity , by 67 and 45 % , respectively , following 24 h of treatment . Positive_regulation NOX1 IL1B 15784009 1425012 *augmented* the expression of the catalytic gp91 subunit of [NADPH oxidase] , gp91phox , as well as inducible NO synthase in ATDC5 cells . Positive_regulation NOX1 IL1B 17673675 1799321 We conclude that in *response* to tumor necrosis factor-alpha and , NADPH oxidase generates ROS within early endosomes and that [Nox1] can not produce sufficient ROS for cell signaling in the absence of ClC-3 . Positive_regulation NOX1 IL1B 17920716 1849147 Perfusion of Mn ( III ) tetrakis ( 4-benzoic acid ) porphyrin chloride , a superoxide ( O ( 2 ) ( - ) ) dismutase mimic , into the mPFC reduced the increases in levels of 2,3-DHBA induced by centrally administered IL-1beta , but enhanced the increases in levels of [NOx] ( - ) *induced* by centrally administered . Positive_regulation NOX1 IL1B 18929641 1994590 , flagellin , interferon-gamma , and tumor necrosis factor alpha (TNF-alpha) similarly *induced* [Nox1] in a colon cancer cell line ( T84 ) , whereas only TNF-alpha fully induced NOXO1 and upregulated superoxide producing activity by ninefold . Positive_regulation NOX1 IL1B 7506289 237765 stimulated production of NO2-/NO3- ( NOx ) in a time dependent manner and both [NOx] and cyclic GMP formation were *stimulated* in a dose dependent manner by IL-1 beta . Positive_regulation NOX1 IL1B 7506289 237769 *induced* [NOx] production and intracellular cyclic GMP formation were similarly blocked by an NO synthase inhibitor , NG-monomethyl-L-arginine ( LNMMA ) , whose effect was reversed by L-arginine , but not by D-arginine . Positive_regulation NOX1 IL1B 7506289 237773 Dexamethasone inhibited *induced* [NOx] production in a dose dependent manner . Positive_regulation NOX1 IL1B 7506289 237777 A calmodulin inhibitor ( W-7 ) showed no effect on *induced* [NOx] production , whereas cycloheximide and the actinomycin D completely inhibited NOx production . Positive_regulation NOX1 IL1B 7517798 261750 dose-dependently ( 0.1 to 10 ng/mL ) *stimulated* [NOx] production as a function of time ( 6 to 48 hours ) . Positive_regulation NOX1 IL1B 7517798 261757 NG-mono-methyl-L-arginine , an NOS inhibitor , completely blocked the *induced* [NOx] production , whose effect was reversed by L-arginine but not by D-arginine . Positive_regulation NOX1 IL1B 7517798 261762 Dexamethasone inhibited the *induced* [NOx] production as well as iNOS mRNA expression . Positive_regulation NOX1 IL1B 7517798 261767 Cycloheximide and actinomycin D completely inhibited the *induced* [NOx] production and iNOS mRNA expression . Positive_regulation NOX1 IL1B 7517798 261771 Neither a calmodulin inhibitor ( W-7 ) , a protein kinase C inhibitor ( calphostin C ) , nor a Ca2+ channel antagonist ( nicardipine ) showed any effect on the *induced* [NOx] production . Positive_regulation NOX1 IL1B 7528993 284168 Among several cytokines and bacterial lipopolysaccharide tested , most effectively *stimulated* [NOx] production . Positive_regulation NOX1 IL1B 7528993 284172 Northern blot analysis using cDNA for mouse liver iNOS as a probe showed that induced expression of iNOS mRNA and *stimulated* [NOx] production in a dose- and time dependent manner . Positive_regulation NOX1 IL1B 7528993 284176 Transforming growth factor (TGF)-beta and dexamethasone blocked the *induced* [NOx] production as well as expression of iNOS mRNA and protein . Positive_regulation NOX1 IL1B 7528993 284181 TGF-beta dose dependently inhibited the *induced* [NOx] production and iNOS mRNA expression . Positive_regulation NOX1 ITGB2 17197441 1702267 We conclude that class IA PI3K serves as a nodal point regulating dependent PMN adhesion and *activation* of [NADPH oxidase] , and leads to oxidant production at sites of PMN adhesion , and the resultant lung microvascular injury in mice . Positive_regulation NOX1 ITGB2 18755982 1992918 dependent *activation* of the neutrophil [NADPH oxidase] during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks . Positive_regulation NOX1 PLAU 18436804 1926425 These effects were related to mediated *activation* of [NADPH oxidase] , and could not be reproduced in mouse peritoneal macrophages ( MPM ) harvested from p47(phox)-/- mice , suggesting a causal relationship between NADPH oxidase activation and the effects of uPA on macrophage oxidative stress and PON2 expression . Positive_regulation NOX1 TLR7 22423966 2572981 Autophagy protein Rubicon mediates phagocytic [NADPH oxidase] activation in *response* to microbial infection or stimulation . Positive_regulation NOX1 TNF 11834706 911123 These data show that endothelial cell p47(phox) is critical in the *upregulation* of [NADPH oxidase] activity by PMA and . Positive_regulation NOX1 TNF 12016268 942384 PKCzeta regulates induced *activation* of [NADPH oxidase] in endothelial cells . Positive_regulation NOX1 TNF 12729920 1086752 In this report , we demonstrate that [NADPH oxidase] is *activated* by plus interferon-gamma (IFN-gamma) in human monocytic cells ( THP-1 cells ) differentiated with phorbol ester ( PMA ) and that physiological concentration of 17beta-estradiol inhibits NADPH oxidase activity in THP-1 cells stimulated with TNF-alpha plus IFN-gamma . Positive_regulation NOX1 TNF 12729920 1086761 Activation of [NADPH oxidase] *induced* by plus IFN-gamma is caused by up-regulation of p47(phox) ( cytosolic component of NADPH oxidase ) expression . Positive_regulation NOX1 TNF 14769150 1182374 The effect of IFN-gamma and on the eosinophilic differentiation and [NADPH oxidase] *activation* of human HL-60 clone 15 cells . Positive_regulation NOX1 TNF 15018305 1183073 Nifedipine completely inhibited *induced* nicotinamide adenine dinucleotide phosphate ( [NADPH) oxidase] activity in HUVEC . Positive_regulation NOX1 TNF 15071361 1232527 Azelnidipine also completely prevented *induced* increase in [NADPH oxidase] activity in HUVEC . Positive_regulation NOX1 TNF 15276019 1276769 Further , PEDF completely prevented the *induced* increase in [NADPH oxidase] activity . Positive_regulation NOX1 TNF 15643139 1363449 Nicotinamide adenine dinucleotide phosphate ( [NAD(P)H) oxidase] is *regulated* by angiotensin II , interleukin (IL)-1beta and via p38 mitogen activated protein kinase (MAPK) . Positive_regulation NOX1 TNF 15743827 1379092 In coronary microvascular EC from p47phox-/- mice , induced [NADPH oxidase] *activation* , ERK1/2 activation , and cell surface intercellular adhesion molecule 1 ( ICAM-1 ) expression were all inhibited . Positive_regulation NOX1 TNF 1618916 191404 *Activation* of the [NADPH oxidase] by phorbol myristate acetate , F- , N-formyl-methionyl-leucyl-phenylalanine ( FMLP ) , or dramatically reduced autofluorescence levels . Positive_regulation NOX1 TNF 16267103 1532093 In summary , our data indicate that *activates* [NAD(P)H oxidase] , resulting in an increase in intracellular H ( 2 ) O ( 2 ) that stimulates Ca ( 2+ ) sparks and transient K ( Ca ) currents , leading to a reduction in global [ Ca ( 2+ ) ] ( i ) , and vasodilation . Positive_regulation NOX1 TNF 16713603 1575816 We also observed a dose dependent decrease in ROS production and [NADPH oxidase] activity *induced* by in the presence of SalB . Positive_regulation NOX1 TNF 16997860 1647250 The aim of this study was to consider ( an ) other ( s ) *role* ( s ) for in facilitating the [NADPH-oxidase] activation by these antibodies . Positive_regulation NOX1 TNF 17560373 1753347 induced *activation* of the Nox1 [NADPH oxidase] and its role in the induction of necrotic cell death . Positive_regulation NOX1 TNF 17560373 1753351 Here we show that also *activates* the Nox1 [NADPH oxidase] in mouse fibroblasts when cells undergo necrosis . Positive_regulation NOX1 TNF 17588511 1764391 In a recent issue of Molecular Cell , Kim et al. ( 2007 ) reported on a novel receptor 1 necrotic signaling complex *inducing* TRADD- and RIP1 dependent recruitment and activation of the ROS generating Nox1 [NADPH oxidase] complex . Positive_regulation NOX1 TNF 17673675 1799320 We conclude that in *response* to and interleukin-1beta , NADPH oxidase generates ROS within early endosomes and that [Nox1] can not produce sufficient ROS for cell signaling in the absence of ClC-3 . Positive_regulation NOX1 TNF 17704189 1822335 We found that alveolar macrophages have high constitutive [NADPH oxidase] activity that was not increased by TNF-alpha , but *increased* the activity of the mitochondrial respiratory chain . Positive_regulation NOX1 TNF 18929641 1994587 Interleukin-1beta , flagellin , interferon-gamma , and similarly *induced* [Nox1] in a colon cancer cell line ( T84 ) , whereas only TNF-alpha fully induced NOXO1 and upregulated superoxide producing activity by ninefold . Positive_regulation NOX1 TNF 19118162 2042344 rapidly *increased* [NADPH oxidase] activity in CMVEC . Positive_regulation NOX1 TNF 19478208 2102428 We hypothesized that resveratrol protects against oxidative stress induced endothelial dysfunction in aortas of diabetic mice by inhibiting induced *activation* of [NAD(P)H oxidase] and preserving phosphorylation of endothelial nitric oxide synthase (eNOS) . Positive_regulation NOX1 TNF 19478208 2102432 Resveratrol restored endothelial function in type 2 diabetes by inhibiting induced *activation* of [NAD(P)H oxidase] and preserving eNOS phosphorylation , suggesting the potential for new treatment approaches to promote vascular health in metabolic diseases . Positive_regulation NOX1 TNF 19546345 2121449 Estrogen at physiological concentration inhibited *stimulated* [NAD(P)H oxidase] activity in both cultured smooth muscle cells and peritoneal macrophages . Positive_regulation NOX1 TNF 20675566 2322642 This improvement is due to the role of resveratrol in inhibiting induced NF-?B activation , therefore subsequently *inhibiting* the expression and activation of [NAD(P)H oxidase] and iNOS as well as increasing eNOS expression in type 2 diabetes . Positive_regulation NOX1 TNF 20729399 2335751 In addition , kallistatin inhibited *induced* reactive oxygen species formation and [NADPH oxidase] activity , and these effects were attenuated by phosphatidylinositol 3-kinase and NOS inhibition . Positive_regulation NOX1 TNF 21088376 2413908 PMN generated reactive oxygen species ( ROS ) in *response* to alone , and [NADPH oxidase] activity increased in response to stimulation with formyl-Met-Leu-Phe after priming . Positive_regulation NOX1 TNF 22182514 2543308 The deficiency in p47phox prevented *induced* [NADPH oxidase] and C2GNT activity and adherence to endothelial cells . Positive_regulation NOX1 TNF 23300968 2725807 Furthermore , *led* to an increased [NAD(P)H oxidase] activity in both sedentary and exercised mice whereas xanthine oxidase activity and intramitochondrial ROS production was only enhanced in sedentary animals by TNF-a . Positive_regulation NOX1 TNF 23774252 2843958 Understanding the regulation of MMP-9 expression and [NADPH oxidase] *activation* by on H9c2 cells may provide potential therapeutic targets of chronic heart failure . Positive_regulation NOX1 TNF 24374371 2917194 Taking these results together , we propose that ileocolitis in the DKO mice is caused by [Nox1] , which is *induced* by . Positive_regulation NOX1 TNF 24401210 2900317 Furthermore , T0901317 reduced the expression of the oxidative stress markers : AT1R , NOX4 , and p22phox and normalized the *induced* [NOX] activity to basal levels . Positive_regulation NOX1 TNF 8906841 394418 Taken together , these findings demonstrate that *activates* the [NADPH oxidase] through stimulation of tyrosine kinases , whose function is cytoskeleton dependent , and raise the problem of whether the activation of this respiratory burst involves signals arising from TNF activated beta2 integrins . Positive_regulation NOX1 TP63 14978110 1213432 These results suggest that p41 ( nox ) and ( nox ) are *involved* in the [Nox1] activation in surface mucous cells of the colon , and besides that , epithelial cells discern pathogenicities among bacteria to appropriately operate Nox1 for the host defense . Positive_regulation NOX3 ADRB2 19330844 2141812 activation *induces* microglial [NADPH oxidase] activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway . Positive_regulation NOX3 CAPN8 18950702 2014311 In conclusion , [NADPH oxidase] *induces* activation , leading to apoptosis in NE-induced cardiomyocytes . Positive_regulation NOX3 CTGF 16612258 1546606 CsA induced myocardial ANP and mRNA overexpression , RAS activation , [NADPH oxidase] *induction* , and NRF2 overexpression were prevented by LA . Positive_regulation NOX3 EPHB2 11211919 763857 These results suggest that the formation of F-actin is dependent on PI3-K and independent of PKC , ERK and p38 MAPK as well as the increase in intracellular Ca2+ , whereas the activation of [NADPH oxidase] is partly *dependent* on , p38 MAPK , Akt regulated by PI3-K , and strongly dependent on the activation of PKC and the increase in intracellular Ca2+ . Positive_regulation NOX3 EPHB2 15894894 1407897 These results suggest that either or p38 MAP-kinase are involved in the activation of both cPLA2 and NADPH oxidase , and that cPLA2 is *required* for activation of the [NADPH oxidase] by Ang II in human neutrophils . Positive_regulation NOX3 EPHB2 18573285 1959242 The subsequent response was increased ROS production associated with *activation* of [NADPH oxidase] ( NOX2 ) and then phosphorylation of MAP kinases ( , JNK ) . Positive_regulation NOX3 EPHB2 21660950 2442618 EGF induced downstream of FAK *requires* [rac1-NADPH oxidase] . Positive_regulation NOX3 FAS 15917250 1433513 These inhibitors and p47phox protein knockdown inhibited the early CD95L induced ROS response , suggesting that ceramide and PKCzeta are upstream events of the *induced* [Nox/Duox] activation . Positive_regulation NOX3 IL1B 10022882 590402 Reactive oxygen intermediate dependent NF-kappaB activation by *requires* 5-lipoxygenase or [NADPH oxidase] activity . Positive_regulation NOX3 IL1B 10086983 599681 After bilateral adrenalectomy , induced a smaller pressor response , but a larger *increase* in plasma [NOx] ; Positive_regulation NOX3 IL1B 10642306 660797 BEL inhibited *stimulated* [NOx] production and iNOS protein by 88 % and 93 % , respectively . Positive_regulation NOX3 IL1B 11880505 919470 In addition , we show that minocycline not only prevents MPTP induced activation of microglia but also the formation of mature and the *activation* of [NADPH-oxidase] and inducible nitric oxide synthase (iNOS) , three key microglial derived cytotoxic mediators . Positive_regulation NOX3 IL1B 14657615 1188529 Both and SNP *enhanced* [NOX] activity , by 67 and 45 % , respectively , following 24 h of treatment . Positive_regulation NOX3 IL1B 15784009 1425013 *augmented* the expression of the catalytic gp91 subunit of [NADPH oxidase] , gp91phox , as well as inducible NO synthase in ATDC5 cells . Positive_regulation NOX3 IL1B 17920716 1849148 Perfusion of Mn ( III ) tetrakis ( 4-benzoic acid ) porphyrin chloride , a superoxide ( O ( 2 ) ( - ) ) dismutase mimic , into the mPFC reduced the increases in levels of 2,3-DHBA induced by centrally administered IL-1beta , but enhanced the increases in levels of [NOx] ( - ) *induced* by centrally administered . Positive_regulation NOX3 IL1B 7506289 237766 Interleukin-1 beta (IL-1 beta) stimulated production of NO2-/NO3- ( NOx ) in a time dependent manner and both [NOx] and cyclic GMP formation were *stimulated* in a dose dependent manner by . Positive_regulation NOX3 IL1B 7506289 237770 *induced* [NOx] production and intracellular cyclic GMP formation were similarly blocked by an NO synthase inhibitor , NG-monomethyl-L-arginine ( LNMMA ) , whose effect was reversed by L-arginine , but not by D-arginine . Positive_regulation NOX3 IL1B 7506289 237774 Dexamethasone inhibited *induced* [NOx] production in a dose dependent manner . Positive_regulation NOX3 IL1B 7506289 237778 A calmodulin inhibitor ( W-7 ) showed no effect on *induced* [NOx] production , whereas cycloheximide and the actinomycin D completely inhibited NOx production . Positive_regulation NOX3 IL1B 7517798 261751 dose-dependently ( 0.1 to 10 ng/mL ) *stimulated* [NOx] production as a function of time ( 6 to 48 hours ) . Positive_regulation NOX3 IL1B 7517798 261758 NG-mono-methyl-L-arginine , an NOS inhibitor , completely blocked the *induced* [NOx] production , whose effect was reversed by L-arginine but not by D-arginine . Positive_regulation NOX3 IL1B 7517798 261763 Dexamethasone inhibited the *induced* [NOx] production as well as iNOS mRNA expression . Positive_regulation NOX3 IL1B 7517798 261768 Cycloheximide and actinomycin D completely inhibited the *induced* [NOx] production and iNOS mRNA expression . Positive_regulation NOX3 IL1B 7517798 261772 Neither a calmodulin inhibitor ( W-7 ) , a protein kinase C inhibitor ( calphostin C ) , nor a Ca2+ channel antagonist ( nicardipine ) showed any effect on the *induced* [NOx] production . Positive_regulation NOX3 IL1B 7528993 284169 Among several cytokines and bacterial lipopolysaccharide tested , most effectively *stimulated* [NOx] production . Positive_regulation NOX3 IL1B 7528993 284173 Northern blot analysis using cDNA for mouse liver iNOS as a probe showed that induced expression of iNOS mRNA and *stimulated* [NOx] production in a dose- and time dependent manner . Positive_regulation NOX3 IL1B 7528993 284177 Transforming growth factor (TGF)-beta and dexamethasone blocked the *induced* [NOx] production as well as expression of iNOS mRNA and protein . Positive_regulation NOX3 IL1B 7528993 284182 TGF-beta dose dependently inhibited the *induced* [NOx] production and iNOS mRNA expression . Positive_regulation NOX3 ITGB2 17197441 1702269 We conclude that class IA PI3K serves as a nodal point regulating dependent PMN adhesion and *activation* of [NADPH oxidase] , and leads to oxidant production at sites of PMN adhesion , and the resultant lung microvascular injury in mice . Positive_regulation NOX3 ITGB2 18755982 1992920 dependent *activation* of the neutrophil [NADPH oxidase] during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks . Positive_regulation NOX3 PLAU 18436804 1926426 These effects were related to *mediated* activation of [NADPH oxidase] , and could not be reproduced in mouse peritoneal macrophages ( MPM ) harvested from p47(phox)-/- mice , suggesting a causal relationship between NADPH oxidase activation and the effects of uPA on macrophage oxidative stress and PON2 expression . Positive_regulation NOX3 TLR7 22423966 2572992 Autophagy protein Rubicon mediates phagocytic [NADPH oxidase] activation in *response* to microbial infection or stimulation . Positive_regulation NOX3 TNF 11834706 911124 These data show that endothelial cell p47(phox) is critical in the *upregulation* of [NADPH oxidase] activity by PMA and . Positive_regulation NOX3 TNF 12016268 942385 PKCzeta regulates *induced* activation of [NADPH oxidase] in endothelial cells . Positive_regulation NOX3 TNF 12729920 1086754 In this report , we demonstrate that [NADPH oxidase] is *activated* by plus interferon-gamma (IFN-gamma) in human monocytic cells ( THP-1 cells ) differentiated with phorbol ester ( PMA ) and that physiological concentration of 17beta-estradiol inhibits NADPH oxidase activity in THP-1 cells stimulated with TNF-alpha plus IFN-gamma . Positive_regulation NOX3 TNF 12729920 1086764 Activation of [NADPH oxidase] *induced* by plus IFN-gamma is caused by up-regulation of p47(phox) ( cytosolic component of NADPH oxidase ) expression . Positive_regulation NOX3 TNF 14769150 1182376 The effect of IFN-gamma and on the eosinophilic differentiation and [NADPH oxidase] *activation* of human HL-60 clone 15 cells . Positive_regulation NOX3 TNF 15018305 1183074 Nifedipine completely inhibited *induced* nicotinamide adenine dinucleotide phosphate ( [NADPH) oxidase] activity in HUVEC . Positive_regulation NOX3 TNF 15071361 1232528 Azelnidipine also completely prevented *induced* increase in [NADPH oxidase] activity in HUVEC . Positive_regulation NOX3 TNF 15276019 1276770 Further , PEDF completely prevented the *induced* increase in [NADPH oxidase] activity . Positive_regulation NOX3 TNF 15643139 1363451 Nicotinamide adenine dinucleotide phosphate ( [NAD(P)H) oxidase] is *regulated* by angiotensin II , interleukin (IL)-1beta and via p38 mitogen activated protein kinase (MAPK) . Positive_regulation NOX3 TNF 15743827 1379093 In coronary microvascular EC from p47phox-/- mice , *induced* [NADPH oxidase] activation , ERK1/2 activation , and cell surface intercellular adhesion molecule 1 ( ICAM-1 ) expression were all inhibited . Positive_regulation NOX3 TNF 1618916 191405 *Activation* of the [NADPH oxidase] by phorbol myristate acetate , F- , N-formyl-methionyl-leucyl-phenylalanine ( FMLP ) , or dramatically reduced autofluorescence levels . Positive_regulation NOX3 TNF 16267103 1532094 In summary , our data indicate that *activates* [NAD(P)H oxidase] , resulting in an increase in intracellular H ( 2 ) O ( 2 ) that stimulates Ca ( 2+ ) sparks and transient K ( Ca ) currents , leading to a reduction in global [ Ca ( 2+ ) ] ( i ) , and vasodilation . Positive_regulation NOX3 TNF 16713603 1575817 We also observed a dose dependent decrease in ROS production and [NADPH oxidase] activity *induced* by in the presence of SalB . Positive_regulation NOX3 TNF 16997860 1647251 The aim of this study was to consider ( an ) other ( s ) *role* ( s ) for in facilitating the [NADPH-oxidase] activation by these antibodies . Positive_regulation NOX3 TNF 17560373 1753348 *induced* activation of the Nox1 [NADPH oxidase] and its role in the induction of necrotic cell death . Positive_regulation NOX3 TNF 17560373 1753352 Here we show that also *activates* the Nox1 [NADPH oxidase] in mouse fibroblasts when cells undergo necrosis . Positive_regulation NOX3 TNF 17588511 1764393 In a recent issue of Molecular Cell , Kim et al. ( 2007 ) reported on a novel receptor 1 necrotic signaling complex *inducing* TRADD- and RIP1 dependent recruitment and activation of the ROS generating Nox1 [NADPH oxidase] complex . Positive_regulation NOX3 TNF 17704189 1822336 We found that alveolar macrophages have high constitutive [NADPH oxidase] activity that was not increased by TNF-alpha , but *increased* the activity of the mitochondrial respiratory chain . Positive_regulation NOX3 TNF 19118162 2042345 rapidly *increased* [NADPH oxidase] activity in CMVEC . Positive_regulation NOX3 TNF 19478208 2102429 We hypothesized that resveratrol protects against oxidative stress induced endothelial dysfunction in aortas of diabetic mice by inhibiting *induced* activation of [NAD(P)H oxidase] and preserving phosphorylation of endothelial nitric oxide synthase (eNOS) . Positive_regulation NOX3 TNF 19478208 2102433 Resveratrol restored endothelial function in type 2 diabetes by inhibiting induced *activation* of [NAD(P)H oxidase] and preserving eNOS phosphorylation , suggesting the potential for new treatment approaches to promote vascular health in metabolic diseases . Positive_regulation NOX3 TNF 19546345 2121450 Estrogen at physiological concentration inhibited *stimulated* [NAD(P)H oxidase] activity in both cultured smooth muscle cells and peritoneal macrophages . Positive_regulation NOX3 TNF 20675566 2322643 This improvement is due to the role of resveratrol in inhibiting induced NF-?B activation , therefore subsequently *inhibiting* the expression and activation of [NAD(P)H oxidase] and iNOS as well as increasing eNOS expression in type 2 diabetes . Positive_regulation NOX3 TNF 20729399 2335753 In addition , kallistatin inhibited *induced* reactive oxygen species formation and [NADPH oxidase] activity , and these effects were attenuated by phosphatidylinositol 3-kinase and NOS inhibition . Positive_regulation NOX3 TNF 21088376 2413910 PMN generated reactive oxygen species ( ROS ) in *response* to alone , and [NADPH oxidase] activity increased in response to stimulation with formyl-Met-Leu-Phe after priming . Positive_regulation NOX3 TNF 22182514 2543309 The deficiency in p47phox prevented *induced* [NADPH oxidase] and C2GNT activity and adherence to endothelial cells . Positive_regulation NOX3 TNF 23300968 2725808 Furthermore , *led* to an increased [NAD(P)H oxidase] activity in both sedentary and exercised mice whereas xanthine oxidase activity and intramitochondrial ROS production was only enhanced in sedentary animals by TNF-a . Positive_regulation NOX3 TNF 23774252 2843960 Understanding the regulation of MMP-9 expression and [NADPH oxidase] *activation* by on H9c2 cells may provide potential therapeutic targets of chronic heart failure . Positive_regulation NOX3 TNF 24401210 2900318 Furthermore , T0901317 reduced the expression of the oxidative stress markers : AT1R , NOX4 , and p22phox and normalized the *induced* [NOX] activity to basal levels . Positive_regulation NOX3 TNF 8906841 394419 Taken together , these findings demonstrate that *activates* the [NADPH oxidase] through stimulation of tyrosine kinases , whose function is cytoskeleton dependent , and raise the problem of whether the activation of this respiratory burst involves signals arising from TNF activated beta2 integrins . Positive_regulation NOX4 ADRB2 19330844 2141813 activation *induces* microglial [NADPH oxidase] activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway . Positive_regulation NOX4 CAPN8 18950702 2014325 In conclusion , [NADPH oxidase] *induces* activation , leading to apoptosis in NE-induced cardiomyocytes . Positive_regulation NOX4 CTGF 16612258 1546611 CsA induced myocardial ANP and mRNA overexpression , RAS activation , [NADPH oxidase] *induction* , and NRF2 overexpression were prevented by LA . Positive_regulation NOX4 EMP1 22465347 2818006 The present study demonstrated for the first time that *induced* upregulation of [Nox4] expression may enhance ROS production in HUVECs . Positive_regulation NOX4 EPHB2 11211919 763858 These results suggest that the formation of F-actin is dependent on PI3-K and independent of PKC , ERK and p38 MAPK as well as the increase in intracellular Ca2+ , whereas the activation of [NADPH oxidase] is partly *dependent* on , p38 MAPK , Akt regulated by PI3-K , and strongly dependent on the activation of PKC and the increase in intracellular Ca2+ . Positive_regulation NOX4 EPHB2 15894894 1407900 These results suggest that either or p38 MAP-kinase are *involved* in the activation of both cPLA2 and [NADPH oxidase] , and that cPLA2 is required for activation of the NADPH oxidase by Ang II in human neutrophils . Positive_regulation NOX4 EPHB2 18573285 1959243 The subsequent response was increased ROS production associated with *activation* of [NADPH oxidase] ( NOX2 ) and then phosphorylation of MAP kinases ( , JNK ) . Positive_regulation NOX4 EPHB2 21660950 2442619 EGF induced downstream of FAK *requires* [rac1-NADPH oxidase] . Positive_regulation NOX4 FAS 15917250 1433514 These inhibitors and p47phox protein knockdown inhibited the early CD95L induced ROS response , suggesting that ceramide and PKCzeta are upstream events of the induced [Nox/Duox] *activation* . Positive_regulation NOX4 IL1B 10022882 590405 Reactive oxygen intermediate dependent NF-kappaB activation by *requires* 5-lipoxygenase or [NADPH oxidase] activity . Positive_regulation NOX4 IL1B 10086983 599682 After bilateral adrenalectomy , induced a smaller pressor response , but a larger *increase* in plasma [NOx] ; Positive_regulation NOX4 IL1B 10642306 660798 BEL inhibited *stimulated* [NOx] production and iNOS protein by 88 % and 93 % , respectively . Positive_regulation NOX4 IL1B 11880505 919471 In addition , we show that minocycline not only prevents MPTP induced activation of microglia but also the formation of mature and the *activation* of [NADPH-oxidase] and inducible nitric oxide synthase (iNOS) , three key microglial derived cytotoxic mediators . Positive_regulation NOX4 IL1B 14657615 1188530 Both and SNP *enhanced* [NOX] activity , by 67 and 45 % , respectively , following 24 h of treatment . Positive_regulation NOX4 IL1B 15784009 1425014 *augmented* the expression of the catalytic gp91 subunit of [NADPH oxidase] , gp91phox , as well as inducible NO synthase in ATDC5 cells . Positive_regulation NOX4 IL1B 17920716 1849149 Perfusion of Mn ( III ) tetrakis ( 4-benzoic acid ) porphyrin chloride , a superoxide ( O ( 2 ) ( - ) ) dismutase mimic , into the mPFC reduced the increases in levels of 2,3-DHBA induced by centrally administered IL-1beta , but enhanced the increases in levels of [NOx] ( - ) *induced* by centrally administered . Positive_regulation NOX4 IL1B 7506289 237767 stimulated production of NO2-/NO3- ( NOx ) in a time dependent manner and both [NOx] and cyclic GMP formation were *stimulated* in a dose dependent manner by IL-1 beta . Positive_regulation NOX4 IL1B 7506289 237771 *induced* [NOx] production and intracellular cyclic GMP formation were similarly blocked by an NO synthase inhibitor , NG-monomethyl-L-arginine ( LNMMA ) , whose effect was reversed by L-arginine , but not by D-arginine . Positive_regulation NOX4 IL1B 7506289 237775 Dexamethasone inhibited *induced* [NOx] production in a dose dependent manner . Positive_regulation NOX4 IL1B 7506289 237779 A calmodulin inhibitor ( W-7 ) showed no effect on *induced* [NOx] production , whereas cycloheximide and the actinomycin D completely inhibited NOx production . Positive_regulation NOX4 IL1B 7517798 261752 dose-dependently ( 0.1 to 10 ng/mL ) *stimulated* [NOx] production as a function of time ( 6 to 48 hours ) . Positive_regulation NOX4 IL1B 7517798 261759 NG-mono-methyl-L-arginine , an NOS inhibitor , completely blocked the *induced* [NOx] production , whose effect was reversed by L-arginine but not by D-arginine . Positive_regulation NOX4 IL1B 7517798 261764 Dexamethasone inhibited the *induced* [NOx] production as well as iNOS mRNA expression . Positive_regulation NOX4 IL1B 7517798 261769 Cycloheximide and actinomycin D completely inhibited the *induced* [NOx] production and iNOS mRNA expression . Positive_regulation NOX4 IL1B 7517798 261773 Neither a calmodulin inhibitor ( W-7 ) , a protein kinase C inhibitor ( calphostin C ) , nor a Ca2+ channel antagonist ( nicardipine ) showed any effect on the *induced* [NOx] production . Positive_regulation NOX4 IL1B 7528993 284170 Among several cytokines and bacterial lipopolysaccharide tested , most effectively *stimulated* [NOx] production . Positive_regulation NOX4 IL1B 7528993 284174 Northern blot analysis using cDNA for mouse liver iNOS as a probe showed that induced expression of iNOS mRNA and *stimulated* [NOx] production in a dose- and time dependent manner . Positive_regulation NOX4 IL1B 7528993 284178 Transforming growth factor (TGF)-beta and dexamethasone blocked the *induced* [NOx] production as well as expression of iNOS mRNA and protein . Positive_regulation NOX4 IL1B 7528993 284183 TGF-beta dose dependently inhibited the *induced* [NOx] production and iNOS mRNA expression . Positive_regulation NOX4 ITGB2 17197441 1702271 We conclude that class IA PI3K serves as a nodal point regulating dependent PMN adhesion and *activation* of [NADPH oxidase] , and leads to oxidant production at sites of PMN adhesion , and the resultant lung microvascular injury in mice . Positive_regulation NOX4 ITGB2 18755982 1992922 dependent *activation* of the neutrophil [NADPH oxidase] during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks . Positive_regulation NOX4 PLAU 18436804 1926427 These effects were related to mediated *activation* of [NADPH oxidase] , and could not be reproduced in mouse peritoneal macrophages ( MPM ) harvested from p47(phox)-/- mice , suggesting a causal relationship between NADPH oxidase activation and the effects of uPA on macrophage oxidative stress and PON2 expression . Positive_regulation NOX4 SPHK1 23933064 2845043 Furthermore , deficiency *attenuated* hyperoxia induced accumulation of IL-6 in bronchoalveolar lavage fluids and NADPH oxidase (NOX) 2 and [NOX4] protein expression in lung tissue . Positive_regulation NOX4 TLR7 22423966 2573003 Autophagy protein Rubicon mediates phagocytic [NADPH oxidase] activation in *response* to microbial infection or stimulation . Positive_regulation NOX4 TNF 11834706 911125 These data show that endothelial cell p47(phox) is critical in the *upregulation* of [NADPH oxidase] activity by PMA and . Positive_regulation NOX4 TNF 12016268 942386 PKCzeta regulates induced *activation* of [NADPH oxidase] in endothelial cells . Positive_regulation NOX4 TNF 12729920 1086756 In this report , we demonstrate that [NADPH oxidase] is *activated* by plus interferon-gamma (IFN-gamma) in human monocytic cells ( THP-1 cells ) differentiated with phorbol ester ( PMA ) and that physiological concentration of 17beta-estradiol inhibits NADPH oxidase activity in THP-1 cells stimulated with TNF-alpha plus IFN-gamma . Positive_regulation NOX4 TNF 12729920 1086767 Activation of [NADPH oxidase] *induced* by plus IFN-gamma is caused by up-regulation of p47(phox) ( cytosolic component of NADPH oxidase ) expression . Positive_regulation NOX4 TNF 14769150 1182378 The effect of IFN-gamma and on the eosinophilic differentiation and [NADPH oxidase] *activation* of human HL-60 clone 15 cells . Positive_regulation NOX4 TNF 15018305 1183075 Nifedipine completely inhibited *induced* nicotinamide adenine dinucleotide phosphate ( [NADPH) oxidase] activity in HUVEC . Positive_regulation NOX4 TNF 15071361 1232529 Azelnidipine also completely prevented *induced* increase in [NADPH oxidase] activity in HUVEC . Positive_regulation NOX4 TNF 15276019 1276771 Further , PEDF completely prevented the *induced* increase in [NADPH oxidase] activity . Positive_regulation NOX4 TNF 15643139 1363453 Nicotinamide adenine dinucleotide phosphate ( [NAD(P)H) oxidase] is *regulated* by angiotensin II , interleukin (IL)-1beta and via p38 mitogen activated protein kinase (MAPK) . Positive_regulation NOX4 TNF 15743827 1379094 In coronary microvascular EC from p47phox-/- mice , induced [NADPH oxidase] *activation* , ERK1/2 activation , and cell surface intercellular adhesion molecule 1 ( ICAM-1 ) expression were all inhibited . Positive_regulation NOX4 TNF 1618916 191406 *Activation* of the [NADPH oxidase] by phorbol myristate acetate , F- , N-formyl-methionyl-leucyl-phenylalanine ( FMLP ) , or dramatically reduced autofluorescence levels . Positive_regulation NOX4 TNF 16267103 1532095 In summary , our data indicate that *activates* [NAD(P)H oxidase] , resulting in an increase in intracellular H ( 2 ) O ( 2 ) that stimulates Ca ( 2+ ) sparks and transient K ( Ca ) currents , leading to a reduction in global [ Ca ( 2+ ) ] ( i ) , and vasodilation . Positive_regulation NOX4 TNF 16713603 1575818 We also observed a dose dependent decrease in ROS production and [NADPH oxidase] activity *induced* by in the presence of SalB . Positive_regulation NOX4 TNF 16997860 1647252 The aim of this study was to consider ( an ) other ( s ) *role* ( s ) for in facilitating the [NADPH-oxidase] activation by these antibodies . Positive_regulation NOX4 TNF 17560373 1753349 induced *activation* of the Nox1 [NADPH oxidase] and its role in the induction of necrotic cell death . Positive_regulation NOX4 TNF 17560373 1753353 Here we show that also *activates* the Nox1 [NADPH oxidase] in mouse fibroblasts when cells undergo necrosis . Positive_regulation NOX4 TNF 17588511 1764395 In a recent issue of Molecular Cell , Kim et al. ( 2007 ) reported on a novel receptor 1 necrotic signaling complex *inducing* TRADD- and RIP1 dependent recruitment and activation of the ROS generating Nox1 [NADPH oxidase] complex . Positive_regulation NOX4 TNF 17704189 1822337 We found that alveolar macrophages have high constitutive [NADPH oxidase] activity that was not increased by TNF-alpha , but *increased* the activity of the mitochondrial respiratory chain . Positive_regulation NOX4 TNF 19118162 2042346 rapidly *increased* [NADPH oxidase] activity in CMVEC . Positive_regulation NOX4 TNF 19478208 2102430 We hypothesized that resveratrol protects against oxidative stress induced endothelial dysfunction in aortas of diabetic mice by inhibiting induced *activation* of [NAD(P)H oxidase] and preserving phosphorylation of endothelial nitric oxide synthase (eNOS) . Positive_regulation NOX4 TNF 19478208 2102434 Resveratrol restored endothelial function in type 2 diabetes by inhibiting *induced* activation of [NAD(P)H oxidase] and preserving eNOS phosphorylation , suggesting the potential for new treatment approaches to promote vascular health in metabolic diseases . Positive_regulation NOX4 TNF 19546345 2121451 Estrogen at physiological concentration inhibited *stimulated* [NAD(P)H oxidase] activity in both cultured smooth muscle cells and peritoneal macrophages . Positive_regulation NOX4 TNF 20675566 2322644 This improvement is due to the role of resveratrol in inhibiting induced NF-?B activation , therefore subsequently *inhibiting* the expression and activation of [NAD(P)H oxidase] and iNOS as well as increasing eNOS expression in type 2 diabetes . Positive_regulation NOX4 TNF 20729399 2335755 In addition , kallistatin inhibited *induced* reactive oxygen species formation and [NADPH oxidase] activity , and these effects were attenuated by phosphatidylinositol 3-kinase and NOS inhibition . Positive_regulation NOX4 TNF 21088376 2413912 PMN generated reactive oxygen species ( ROS ) in *response* to alone , and [NADPH oxidase] activity increased in response to stimulation with formyl-Met-Leu-Phe after priming . Positive_regulation NOX4 TNF 22182514 2543310 The deficiency in p47phox prevented *induced* [NADPH oxidase] and C2GNT activity and adherence to endothelial cells . Positive_regulation NOX4 TNF 23300968 2725809 Furthermore , *led* to an increased [NAD(P)H oxidase] activity in both sedentary and exercised mice whereas xanthine oxidase activity and intramitochondrial ROS production was only enhanced in sedentary animals by TNF-a . Positive_regulation NOX4 TNF 23774252 2843962 Understanding the regulation of MMP-9 expression and [NADPH oxidase] *activation* by on H9c2 cells may provide potential therapeutic targets of chronic heart failure . Positive_regulation NOX4 TNF 24401210 2900319 Furthermore , T0901317 reduced the expression of the oxidative stress markers : AT1R , NOX4 , and p22phox and normalized the *induced* [NOX] activity to basal levels . Positive_regulation NOX4 TNF 8906841 394420 Taken together , these findings demonstrate that *activates* the [NADPH oxidase] through stimulation of tyrosine kinases , whose function is cytoskeleton dependent , and raise the problem of whether the activation of this respiratory burst involves signals arising from TNF activated beta2 integrins . Positive_regulation NOX4 TNFSF10 19876066 2232143 These results collectively indicate that *induced* activation of PKCdelta and [NOX4] can modulate TRAIL mediated apoptosis by promoting oxidative modification of active caspase-3 in a negative-feedback manner . Positive_regulation NOX5 ADRB2 19330844 2141806 activation *induces* microglial [NADPH oxidase] activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway . Positive_regulation NOX5 CAPN8 18950702 2014275 In conclusion , [NADPH oxidase] *induces* activation , leading to apoptosis in NE-induced cardiomyocytes . Positive_regulation NOX5 CTGF 16612258 1546580 CsA induced myocardial ANP and mRNA overexpression , RAS activation , [NADPH oxidase] *induction* , and NRF2 overexpression were prevented by LA . Positive_regulation NOX5 EPHB2 11211919 763855 These results suggest that the formation of F-actin is dependent on PI3-K and independent of PKC , ERK and p38 MAPK as well as the increase in intracellular Ca2+ , whereas the activation of [NADPH oxidase] is partly *dependent* on , p38 MAPK , Akt regulated by PI3-K , and strongly dependent on the activation of PKC and the increase in intracellular Ca2+ . Positive_regulation NOX5 EPHB2 15894894 1407884 These results suggest that either or p38 MAP-kinase are *involved* in the activation of both cPLA2 and [NADPH oxidase] , and that cPLA2 is required for activation of the NADPH oxidase by Ang II in human neutrophils . Positive_regulation NOX5 EPHB2 18573285 1959240 The subsequent response was increased ROS production associated with *activation* of [NADPH oxidase] ( NOX2 ) and then phosphorylation of MAP kinases ( , JNK ) . Positive_regulation NOX5 EPHB2 21297032 2410387 The mutation of S498 to a nonphosphorylatable residue and to a lesser degree T494 blocked the ability of to *stimulate* [Nox5] activity . Positive_regulation NOX5 EPHB2 21660950 2442612 EGF induced downstream of FAK *requires* [rac1-NADPH oxidase] . Positive_regulation NOX5 FAS 15917250 1433510 These inhibitors and p47phox protein knockdown inhibited the early CD95L induced ROS response , suggesting that ceramide and PKCzeta are upstream events of the induced [Nox/Duox] *activation* . Positive_regulation NOX5 IL1B 10022882 590382 Reactive oxygen intermediate dependent NF-kappaB activation by *requires* 5-lipoxygenase or [NADPH oxidase] activity . Positive_regulation NOX5 IL1B 10086983 599679 After bilateral adrenalectomy , induced a smaller pressor response , but a larger *increase* in plasma [NOx] ; Positive_regulation NOX5 IL1B 10642306 660795 BEL inhibited *stimulated* [NOx] production and iNOS protein by 88 % and 93 % , respectively . Positive_regulation NOX5 IL1B 11880505 919462 In addition , we show that minocycline not only prevents MPTP induced activation of microglia but also the formation of mature and the *activation* of [NADPH-oxidase] and inducible nitric oxide synthase (iNOS) , three key microglial derived cytotoxic mediators . Positive_regulation NOX5 IL1B 14657615 1188527 Both and SNP *enhanced* [NOX] activity , by 67 and 45 % , respectively , following 24 h of treatment . Positive_regulation NOX5 IL1B 15784009 1425009 *augmented* the expression of the catalytic gp91 subunit of [NADPH oxidase] , gp91phox , as well as inducible NO synthase in ATDC5 cells . Positive_regulation NOX5 IL1B 17920716 1849146 Perfusion of Mn ( III ) tetrakis ( 4-benzoic acid ) porphyrin chloride , a superoxide ( O ( 2 ) ( - ) ) dismutase mimic , into the mPFC reduced the increases in levels of 2,3-DHBA induced by centrally administered IL-1beta , but enhanced the increases in levels of [NOx] ( - ) *induced* by centrally administered . Positive_regulation NOX5 IL1B 7506289 237763 Interleukin-1 beta (IL-1 beta) stimulated production of NO2-/NO3- ( NOx ) in a time dependent manner and both [NOx] and cyclic GMP formation were *stimulated* in a dose dependent manner by . Positive_regulation NOX5 IL1B 7506289 237768 *induced* [NOx] production and intracellular cyclic GMP formation were similarly blocked by an NO synthase inhibitor , NG-monomethyl-L-arginine ( LNMMA ) , whose effect was reversed by L-arginine , but not by D-arginine . Positive_regulation NOX5 IL1B 7506289 237772 Dexamethasone inhibited *induced* [NOx] production in a dose dependent manner . Positive_regulation NOX5 IL1B 7506289 237776 A calmodulin inhibitor ( W-7 ) showed no effect on *induced* [NOx] production , whereas cycloheximide and the actinomycin D completely inhibited NOx production . Positive_regulation NOX5 IL1B 7517798 261749 dose-dependently ( 0.1 to 10 ng/mL ) *stimulated* [NOx] production as a function of time ( 6 to 48 hours ) . Positive_regulation NOX5 IL1B 7517798 261756 NG-mono-methyl-L-arginine , an NOS inhibitor , completely blocked the *induced* [NOx] production , whose effect was reversed by L-arginine but not by D-arginine . Positive_regulation NOX5 IL1B 7517798 261760 Dexamethasone inhibited the *induced* [NOx] production as well as iNOS mRNA expression . Positive_regulation NOX5 IL1B 7517798 261765 Cycloheximide and actinomycin D completely inhibited the *induced* [NOx] production and iNOS mRNA expression . Positive_regulation NOX5 IL1B 7517798 261770 Neither a calmodulin inhibitor ( W-7 ) , a protein kinase C inhibitor ( calphostin C ) , nor a Ca2+ channel antagonist ( nicardipine ) showed any effect on the *induced* [NOx] production . Positive_regulation NOX5 IL1B 7528993 284167 Among several cytokines and bacterial lipopolysaccharide tested , most effectively *stimulated* [NOx] production . Positive_regulation NOX5 IL1B 7528993 284171 Northern blot analysis using cDNA for mouse liver iNOS as a probe showed that induced expression of iNOS mRNA and *stimulated* [NOx] production in a dose- and time dependent manner . Positive_regulation NOX5 IL1B 7528993 284175 Transforming growth factor (TGF)-beta and dexamethasone blocked the *induced* [NOx] production as well as expression of iNOS mRNA and protein . Positive_regulation NOX5 IL1B 7528993 284179 TGF-beta dose dependently inhibited the *induced* [NOx] production and iNOS mRNA expression . Positive_regulation NOX5 ITGB2 17197441 1702265 We conclude that class IA PI3K serves as a nodal point regulating dependent PMN adhesion and *activation* of [NADPH oxidase] , and leads to oxidant production at sites of PMN adhesion , and the resultant lung microvascular injury in mice . Positive_regulation NOX5 ITGB2 18755982 1992916 dependent *activation* of the neutrophil [NADPH oxidase] during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks . Positive_regulation NOX5 PLAU 18436804 1926424 These effects were related to *mediated* activation of [NADPH oxidase] , and could not be reproduced in mouse peritoneal macrophages ( MPM ) harvested from p47(phox)-/- mice , suggesting a causal relationship between NADPH oxidase activation and the effects of uPA on macrophage oxidative stress and PON2 expression . Positive_regulation NOX5 TLR7 22423966 2572960 Autophagy protein Rubicon mediates phagocytic [NADPH oxidase] activation in *response* to microbial infection or stimulation . Positive_regulation NOX5 TNF 11834706 911122 These data show that endothelial cell p47(phox) is critical in the *upregulation* of [NADPH oxidase] activity by PMA and . Positive_regulation NOX5 TNF 12016268 942383 PKCzeta regulates induced *activation* of [NADPH oxidase] in endothelial cells . Positive_regulation NOX5 TNF 12729920 1086750 In this report , we demonstrate that [NADPH oxidase] is *activated* by plus interferon-gamma (IFN-gamma) in human monocytic cells ( THP-1 cells ) differentiated with phorbol ester ( PMA ) and that physiological concentration of 17beta-estradiol inhibits NADPH oxidase activity in THP-1 cells stimulated with TNF-alpha plus IFN-gamma . Positive_regulation NOX5 TNF 12729920 1086758 Activation of [NADPH oxidase] *induced* by plus IFN-gamma is caused by up-regulation of p47(phox) ( cytosolic component of NADPH oxidase ) expression . Positive_regulation NOX5 TNF 14769150 1182372 The effect of IFN-gamma and on the eosinophilic differentiation and [NADPH oxidase] *activation* of human HL-60 clone 15 cells . Positive_regulation NOX5 TNF 15018305 1183072 Nifedipine completely inhibited *induced* nicotinamide adenine dinucleotide phosphate ( [NADPH) oxidase] activity in HUVEC . Positive_regulation NOX5 TNF 15071361 1232526 Azelnidipine also completely prevented *induced* increase in [NADPH oxidase] activity in HUVEC . Positive_regulation NOX5 TNF 15276019 1276768 Further , PEDF completely prevented the *induced* increase in [NADPH oxidase] activity . Positive_regulation NOX5 TNF 15643139 1363447 Nicotinamide adenine dinucleotide phosphate ( [NAD(P)H) oxidase] is *regulated* by angiotensin II , interleukin (IL)-1beta and via p38 mitogen activated protein kinase (MAPK) . Positive_regulation NOX5 TNF 15743827 1379089 In coronary microvascular EC from p47phox-/- mice , *induced* [NADPH oxidase] activation , ERK1/2 activation , and cell surface intercellular adhesion molecule 1 ( ICAM-1 ) expression were all inhibited . Positive_regulation NOX5 TNF 1618916 191403 *Activation* of the [NADPH oxidase] by phorbol myristate acetate , F- , N-formyl-methionyl-leucyl-phenylalanine ( FMLP ) , or dramatically reduced autofluorescence levels . Positive_regulation NOX5 TNF 16267103 1532092 In summary , our data indicate that *activates* [NAD(P)H oxidase] , resulting in an increase in intracellular H ( 2 ) O ( 2 ) that stimulates Ca ( 2+ ) sparks and transient K ( Ca ) currents , leading to a reduction in global [ Ca ( 2+ ) ] ( i ) , and vasodilation . Positive_regulation NOX5 TNF 16713603 1575815 We also observed a dose dependent decrease in ROS production and [NADPH oxidase] activity *induced* by in the presence of SalB . Positive_regulation NOX5 TNF 16997860 1647249 The aim of this study was to consider ( an ) other ( s ) *role* ( s ) for in facilitating the [NADPH-oxidase] activation by these antibodies . Positive_regulation NOX5 TNF 17560373 1753346 *induced* activation of the Nox1 [NADPH oxidase] and its role in the induction of necrotic cell death . Positive_regulation NOX5 TNF 17560373 1753350 Here we show that also *activates* the Nox1 [NADPH oxidase] in mouse fibroblasts when cells undergo necrosis . Positive_regulation NOX5 TNF 17588511 1764389 In a recent issue of Molecular Cell , Kim et al. ( 2007 ) reported on a novel receptor 1 necrotic signaling complex *inducing* TRADD- and RIP1 dependent recruitment and activation of the ROS generating Nox1 [NADPH oxidase] complex . Positive_regulation NOX5 TNF 17704189 1822334 We found that alveolar macrophages have high constitutive [NADPH oxidase] activity that was not increased by TNF-alpha , but *increased* the activity of the mitochondrial respiratory chain . Positive_regulation NOX5 TNF 19118162 2042343 rapidly *increased* [NADPH oxidase] activity in CMVEC . Positive_regulation NOX5 TNF 19478208 2102427 We hypothesized that resveratrol protects against oxidative stress induced endothelial dysfunction in aortas of diabetic mice by inhibiting *induced* activation of [NAD(P)H oxidase] and preserving phosphorylation of endothelial nitric oxide synthase (eNOS) . Positive_regulation NOX5 TNF 19478208 2102431 Resveratrol restored endothelial function in type 2 diabetes by inhibiting *induced* activation of [NAD(P)H oxidase] and preserving eNOS phosphorylation , suggesting the potential for new treatment approaches to promote vascular health in metabolic diseases . Positive_regulation NOX5 TNF 19546345 2121448 Estrogen at physiological concentration inhibited *stimulated* [NAD(P)H oxidase] activity in both cultured smooth muscle cells and peritoneal macrophages . Positive_regulation NOX5 TNF 20675566 2322639 This improvement is due to the role of resveratrol in inhibiting induced NF-?B activation , therefore subsequently *inhibiting* the expression and activation of [NAD(P)H oxidase] and iNOS as well as increasing eNOS expression in type 2 diabetes . Positive_regulation NOX5 TNF 20729399 2335749 In addition , kallistatin inhibited *induced* reactive oxygen species formation and [NADPH oxidase] activity , and these effects were attenuated by phosphatidylinositol 3-kinase and NOS inhibition . Positive_regulation NOX5 TNF 21088376 2413906 PMN generated reactive oxygen species ( ROS ) in *response* to alone , and [NADPH oxidase] activity increased in response to stimulation with formyl-Met-Leu-Phe after priming . Positive_regulation NOX5 TNF 22182514 2543306 The deficiency in p47phox prevented *induced* [NADPH oxidase] and C2GNT activity and adherence to endothelial cells . Positive_regulation NOX5 TNF 22427510 2594310 In HVSMC , angiotensin II , endothelin-1 and *increased* endogenous [Nox5] mRNA levels , while adenovirus mediated overexpression of Nox5 promoted p38 MAPK , JAK2 , JNK , and ERK1/2 phosphorylation in endothelial cells ( EC ) , but only increased ERK1/2 phosphorylation in HVSMC . Positive_regulation NOX5 TNF 23300968 2725806 Furthermore , *led* to an increased [NAD(P)H oxidase] activity in both sedentary and exercised mice whereas xanthine oxidase activity and intramitochondrial ROS production was only enhanced in sedentary animals by TNF-a . Positive_regulation NOX5 TNF 23774252 2843955 Understanding the regulation of MMP-9 expression and [NADPH oxidase] *activation* by on H9c2 cells may provide potential therapeutic targets of chronic heart failure . Positive_regulation NOX5 TNF 24401210 2900316 Furthermore , T0901317 reduced the expression of the oxidative stress markers : AT1R , NOX4 , and p22phox and normalized the *induced* [NOX] activity to basal levels . Positive_regulation NOX5 TNF 8906841 394417 Taken together , these findings demonstrate that *activates* the [NADPH oxidase] through stimulation of tyrosine kinases , whose function is cytoskeleton dependent , and raise the problem of whether the activation of this respiratory burst involves signals arising from TNF activated beta2 integrins . Positive_regulation NOXO1 TNF 18929641 1994580 Interleukin-1beta , flagellin , interferon-gamma , and tumor necrosis factor alpha (TNF-alpha) similarly induced Nox1 in a colon cancer cell line ( T84 ) , whereas only fully *induced* [NOXO1] and upregulated superoxide producing activity by ninefold . Positive_regulation NOXO1 TNF 18929641 1994591 Serial mutation analysis of the elements identified an AP-1 binding site ( from -561 to -551 bp , agtAAGtcatg ) as a crucial element for *stimulated* transcription of the human [NOXO1] gene , which was also confirmed by the AP-1 decoy experiments . Positive_regulation NPEPPS EPHB2 19274665 2079743 We observed kinase inhibitor , U0126 , but not phosphatidylinositol 3-kinase (PI-3K) , LY294002 , or protein kinase A (PKA) inhibitor , H-89 , *inhibited* stromal CM or androgen induced [PSA] promoter luciferase activities , and anchorage independent growth of LNCaP cells . Positive_regulation NPEPPS PLAT 10603431 575021 These results suggest that up-regulated may *contribute* to the degradation of [PSA-NCAM] . Positive_regulation NPEPPS TNF 10996034 733711 In in vitro experiments using human peripheral blood mononuclear cells ( PBMC ) , [OK-PSA] *induced* IFN-gamma , interleukin (IL)-2 , IL-12 , IL-18 , and TNF-beta that are generally called `` Th1-type cytokines '' both in protein and in mRNA levels . Positive_regulation NPEPPS TNF 21864268 2505691 was the first successful *target* of cytokine inhibition therapy for psoriasis and [PsA] ( e.g. , infliximab , adalimumab , and etanercept ) . Positive_regulation NPEPPS TNF 8835089 344633 In the Indo+TNF group the early *induced* rise in [Psa] was blunted compared to the TNF group [ 2.9 +/- 1.2 vs. 3.6 +/- 0.8 kPa ( 22 +/- 3 vs. 27 +/- 6 mm Hg ; p < 0.04 ) ] as were the late decreases in pH and Psa ( p < 0.04 ) . Positive_regulation NPNT MYLIP 19844573 2155538 MicroRNA *regulates* [nephronectin] expression modulating osteoblast differentiation by targeting GalNT-7 . Positive_regulation NPNT SMAD1 22842459 2646555 [Nephronectin] expression is *regulated* by signaling in osteoblast-like MC3T3-E1 cells . Positive_regulation NPNT SMAD2 22842459 2646556 [Nephronectin] expression is *regulated* by signaling in osteoblast-like MC3T3-E1 cells . Positive_regulation NPNT SMAD3 22842459 2646557 [Nephronectin] expression is *regulated* by signaling in osteoblast-like MC3T3-E1 cells . Positive_regulation NPNT SMAD4 22842459 2646558 [Nephronectin] expression is *regulated* by signaling in osteoblast-like MC3T3-E1 cells . Positive_regulation NPNT SMAD5 22842459 2646559 [Nephronectin] expression is *regulated* by signaling in osteoblast-like MC3T3-E1 cells . Positive_regulation NPNT SMAD6 22842459 2646560 [Nephronectin] expression is *regulated* by signaling in osteoblast-like MC3T3-E1 cells . Positive_regulation NPNT SMAD7 22842459 2646561 [Nephronectin] expression is *regulated* by signaling in osteoblast-like MC3T3-E1 cells . Positive_regulation NPNT SMAD9 22842459 2646562 [Nephronectin] expression is *regulated* by signaling in osteoblast-like MC3T3-E1 cells . Positive_regulation NPNT TGFBR1 22842459 2646571 The inhibitor *induced* increase of [Npnt] expression occurred in both time- and dose dependent manners , while that expression was also induced by introduction of an siRNA for Smad2 , a central intracellular mediator of TGF-ß signaling . Positive_regulation NPPA EDN2 14716210 1197458 The aim of the present study was to investigate the putative *role* of in mediating ischemia/hypoxia induced [ANP] release utilizing exogenous ET-1 or ET receptor antagonists ( BQ-123 or Bosentan ) . Positive_regulation NPPA EDN2 1531104 180272 Norepinephrine and *increased* [ANP] secretion 144 +/- 16 and 136 +/- 2 % above baseline , respectively . Positive_regulation NPPA EDN2 1828025 158518 produced a concentration related *increase* in the secretion of [ANP] . Positive_regulation NPPA EDN2 1828025 158521 The ability of to *induce* [ANP] secretion was dependent upon calcium , since added nifedipine , a calcium channel blocker , significantly reversed the effects of this vasoconstrictor peptide . Positive_regulation NPPA EDN2 1828025 158524 These studies provide the first evidence that *regulates* [ANP] gene expression in the brain . Positive_regulation NPPA EDN2 2163306 136005 ( 1-100 nM ) *increased* [ANP] secretion in a dose dependent manner from 1.6- to 6.7-fold above baseline . Positive_regulation NPPA EDN2 2163306 136008 The calcium dependency of *stimulated* [ANP] secretion was examined using paced left atria . Positive_regulation NPPA EDN2 2163306 136014 Nitrendipine decreased *stimulated* [ANP] secretion by 51 % without affecting endothelin binding . Positive_regulation NPPA EDN2 2163306 136017 Ryanodine had no effect on *stimulated* [ANP] secretion . Positive_regulation NPPA EDN2 8377212 229993 [ANP] secretion is *stimulated* by . Positive_regulation NPPA EDN2 8601621 351915 Each of these agents reduced *stimulated* [ANP] secretion in a dose dependent fashion and the two in combination proved to be more effective than either agent used alone ( VD3 : 49 % ; Positive_regulation NPPA EDN2 8690006 370540 In contrast , left atrial [ANP] secretion is *stimulated* by and 3 but not 1 . Positive_regulation NPPA EDN2 9513855 492091 *stimulates* [ANP] secretion and its concentration increases after heart transplantation , suggesting a role for this peptide in the cardiovascular adaptative response to heart transplantation . Positive_regulation NPPA EDN2 9513855 492097 To investigate whether may induce [ANP] *increase* in heart transplant recipients , we monitored daily ANP , endothelin , and related hormonal , biologic , and hemodynamic parameters before and during the first week after either heart transplantation ( n = 15 ) or coronary artery bypass grafting ( n = 10 ) . Positive_regulation NPPA EDN2 9513855 492103 Elevated , suggesting vascular dysfunction , likely *contributes* to the [ANP] increase observed early after heart transplantation . Positive_regulation NPPA GLP1R 23542788 2777713 Cardiomyocyte GLP-1R activation promoted the translocation of the Rap guanine nucleotide exchange factor Epac2 ( also known as Rapgef4 ) to the membrane , whereas Epac2 deficiency eliminated *dependent* stimulation of [ANP] secretion . Positive_regulation NPPA IL1B 10591026 572504 In the MC-NMC coculture , and ET-1 each significantly *augmented* the secretion of [ANP] and BNP . Positive_regulation NPPA IL1B 10591026 572506 This study shows that *induces* unique cardiac hypertrophy and the marked secretion of [ANP] and BNP , and that NMC is indispensable when treated with IL-1 beta . Positive_regulation NPPA IL1B 8396869 230339 To assess the central *role* of in the release of ACTH , vasopressin ( AVP ) and [atrial natriuretic peptide (ANP)] and in the regulation of blood pressure and thermogenesis , 3 ng ( 0.173 pM ) x 100-1 x BW-1 ( LIL ) , 30 ng ( 1.73 pM ) x 100g-1 x BW-1 ( MIL ) , and 150 ng ( 8.63 pM ) x 100g-1 x BW-1 ( HIL ) of human IL-1 beta dissolved in sterile saline were injected intracerebroventricularly to conscious rats . Positive_regulation NPPA IL1B 8396869 230341 In the LIL group , *increased* blood pressure , body temperature and plasma AVP and [ANP] without any changes in heart rate ( HR ) and plasma ACTH . Positive_regulation NPPA IL1B 8693488 343287 *increased* significantly plasma [ANP] and AVP and UNa V , but not UF , accompanied by decreases in Posm and UKV and increases in MABP ( ExI ) . Positive_regulation NPPA TNF 18186083 1863099 However , [ANP] does not *induce* NO synthase Type 2 (NOS-2) or expression and is able to decrease lipopolysaccharide (LPS) elicited induction of these inflammatory genes . Positive_regulation NPPA TNF 21130119 2390084 [ANP] *induced* the release of histamine and from RPMCs and enhanced serotonin release from MPMCs , in a dose dependent fashion , as well as reduced cAMP level of RPMCs in vitro . Positive_regulation NPR1 EDN2 12623978 1066542 Although exogenous *had* little or no effect on basal expression of eNOS mRNA or protein or [NPR-A] gene expression , both the type A ( BQ610 ) and type B ( IRL1038 ) endothelin receptor antagonists proved capable of reducing eNOS mRNA and protein expression , and increasing levels of the NPR-A mRNA . Positive_regulation NPR2 PLAU 21395696 2438303 Plasminogen activator inhibitors (PAI)-1 , 2 and the receptor were also *targets* for [NprB] in vitro . Positive_regulation NPS IL1B 14698853 1195822 To investigate whether this peptide hyporesponsiveness in LEW/N cells is secondary to their deficient mRNA expression , temporal mRNA expression patterns of CRH , AVP , and several hypothalamic [neuropeptides] *induced* by in LEW/N and F344/N hypothalamic dissociated cell cultures were delineated by quantitative real-time polymerase chain reaction ( RT-PCR ) . Positive_regulation NPS TNF 16492228 1528637 The transient increase in sICAM-1 and found in the internal jugular blood of MWoA patients assessed ictally can be *induced* by sensory [neuropeptides] released from activated trigeminal endings . Positive_regulation NPS TNF 18180317 1856486 In addition , GLP-1 attenuated *mediated* induction of Nur77 mRNA and TNF-alpha mediated binding of [nuclear proteins (NPs)] to the PAI-1 , Nur77 , cis acting response element nerve growth factor induced clone B response element ( NBRE ) . Positive_regulation NPS TNF 20933561 2369022 In PAMs , [NPS] could *induce* the production of the pro-inflammatory cytokines IL-1ß , IL-6 and . Positive_regulation NPTX1 BPI 8040321 266669 and p15A display similar features of antibacterial action distinct from defensin NP-1 , but [NP-1] *acts* synergistically only with BPI and not with p15A . Positive_regulation NPY EDN2 12234805 988922 *induced* modulation of [neuropeptide Y] and norepinephrine release from the rat mesenteric bed . Positive_regulation NPY EPHB2 24699455 2949435 We found that NPY induced a dose dependent migration of human monocyte derived immature DCs through the engagement of [NPY] Y1 receptor and the *activation* of and p38 mitogen activated protein kinases . Positive_regulation NPY FOXO1 22876196 2641520 Increased Dyrk1a activated Sirt1 to regulate the deacetylation of FOXO , which potentiated *induced* [sNPF/NPY] expression and in turn promoted food intake . Positive_regulation NPY IL1B 11277982 798045 *induces* expression of [neuropeptide Y] in primary astrocyte cultures in a cytokine-specific manner : induction in human but not rat astrocytes . Positive_regulation NPY IL1B 11277982 798047 , but not IL-6 or TNF-alpha , *led* to an increase in [NPY] production dose-dependently . Positive_regulation NPY IL1B 11277982 798051 In summary , we demonstrate that *induction* of [NPY] expression in astrocytes is species- and cytokine-specific and that IL-1 receptor is involved . Positive_regulation NPY IL1B 19309436 2073459 We observed that *increases* the release of [NPY] , norepinephrine ( NE ) , and epinephrine ( EP ) from human chromaffin cells . Positive_regulation NPY IL1B 9323447 456568 *induces* anorexia and [neuropeptide Y (NPY)] increases feeding by direct action in the central nervous system ( CNS ) . Positive_regulation NPY NT5E 8891268 391930 Under none of these conditions did BDNF , , NT-3 or NGF *induce* an increase in [NPY] production . Positive_regulation NPY TNF 11277982 798046 IL-1beta , but not IL-6 or , *led* to an increase in [NPY] production dose-dependently . Positive_regulation NPY TNF 24108115 2852589 Here , we investigated if [NPY] expression during inflammation is *induced* by , the main proinflammatory cytokine . Positive_regulation NPY TNF 24108115 2852590 Further , we assessed if [NPY] expression is *inducible* by in enteric neuronal cells and mouse model of experimental colitis , using the TNF inhibitors-etanercept ( blocks transmembrane and soluble TNF ) and XPro1595 ( blocks soluble TNF only ) . Positive_regulation NPY TNF 24108115 2852591 Further , *activated* [NPY] promoter in enteric neurons through phospho-c-Jun. NPY ( -/- ) mice had decreased intestinal permeability . Positive_regulation NPY4R EPHB2 19778233 2141053 The induction of TNF-alpha and TGF-beta1 by silica was suppressed by Src *inhibitor* ( [PP1] ) , inhibitor ( PD98059 ) , but not by p38 kinase inhibitor ( SB203580 ) . Positive_regulation NPY4R TNF 17158207 1694198 *increased* serine/threonine phosphatase activity of protein [phosphatase 1 (PP1)] in response to C6 , but not insulin , suggesting a ceramide-specific effect . Positive_regulation NPY4R TNF 24089494 2848160 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed receptor 1 and *requires* activation of p38 MAPK , phosphatidylinositol 3-kinase , protein [phosphatase 1 (PP1)] , and dynamin GTPase . Positive_regulation NPY5R TNF 14599717 1161301 Y1 and Y2 receptors were expressed in basal conditions , and LPS , and IFN-gamma *induced* [Y5 receptor] expression with a concomitant extinction of Y2 receptor expression . Positive_regulation NPY6R EPHB2 19508391 2108583 Effects of tripterine were investigated on endothelial barrier function , inducible nitric oxide synthase (iNOS) expression , nicotinamide adenine dinucleotide phasphate ( NADPH) oxidase activity , 3-nitrotyrosine formation , protein [phosphatase type 2A (PP2A)] activity , *activation* of , c-Jun terminal kinase (JNK) and Janus kinase ( Jak2 ) , and degradation of IkappaB in microvascular endothelial cells exposed to pro-inflammatory stimulus [ lipopolysaccharide (LPS) + interferon gamma (IFNgamma) ] and on vascular permeability in air pouches of mice injected with LPS + IFNgamma . Positive_regulation NQO1 ARSA 16267095 1532082 Compared with untreated Min mice , *increased* in the liver the activity ( nmol/min/mg ; mean+/-SEM for all ) of [NQO] ( 85+/-6 versus 128+/-11 , P < 0.05 ) and GST ( 2560+/-233 versus 4254+/-608 , P < 0.005 ) and also in the intestine but not in the kidney ; Positive_regulation NQO1 ARSA 22209714 2549749 Pretreatment of cells with NaF , an esterase inhibitor , abrogated the *mediated* increases in [NQO1] enzyme activity . Positive_regulation NQO1 TNF 16682409 1584065 We also found that *activated* [NQO1] , and NQO1-specific small interfering RNA abolished the TNF induced NQO1 activity and NF-kappaB activation . Positive_regulation NQO2 ARSA 16267095 1532083 Compared with untreated Min mice , *increased* in the liver the activity ( nmol/min/mg ; mean+/-SEM for all ) of [NQO] ( 85+/-6 versus 128+/-11 , P < 0.05 ) and GST ( 2560+/-233 versus 4254+/-608 , P < 0.005 ) and also in the intestine but not in the kidney ; Positive_regulation NQO2 TNF 17942934 1814228 In agreement with this , we also found that *activated* [NQO2] , and NQO2-specific small interfering RNA abrogated the TNF induced NQO2 activity and NF-kappaB activation . Positive_regulation NR0B1 IL1B 16202978 1468540 First , we found that [DSS] markedly *induced* production in both dose- and time dependent manners ( P < 0.05 and P < 0.01 , respectively ) in murine peritoneal macrophages ( pMphi ) , while that of tumor necrosis factor-alpha was insignificant . Positive_regulation NR1D1 RNASE1 12853122 1110019 The bactericidal activities of mature [Ear-1] ( Q ) and mature Ear-2 ( Q ) were not *inhibited* by inhibitor , but was increased by treatment at 96 degrees C for 20 min . Positive_regulation NR1D1 RNASE7 12853122 1110027 The bactericidal activities of mature [Ear-1] ( Q ) and mature Ear-2 ( Q ) were not *inhibited* by inhibitor , but was increased by treatment at 96 degrees C for 20 min . Positive_regulation NR1I2 CYP24A1 16691293 1563742 However , here we showed that activation of [SXR] did not *induce* expression in vitro and in vivo , nor did it transactivate the CYP24 promoter . Positive_regulation NR1I2 IL1B 20460758 2257488 However , rifampicin the nuclear receptor steroid and xenobiotic receptor (SXR) ligand had no effect of IL-beta , suggesting that is *involved* in VK ( 2 ) dependent gamma-calboxylation but not [SXR-activation] . Positive_regulation NR1I3 EPHB2 11097627 755788 We analyzed the kinetics of *activation* of and PLA(2) by the [CaR] in response to Ca ( 2+ ) , Co ( 2+ ) , and Pb ( 2+ ) . Positive_regulation NR1I3 EPHB2 17426287 1742285 Interestingly , this Rab11a dominant negative mutant does not interfere with CaR dependent activation of ERK 1/2 , suggesting that signaling is not *sufficient* to promote PTHrP secretion downstream of [CaR] . Positive_regulation NR1I3 TNF 14664720 1177712 *had* no effect on PTH secretion , and PTH and [CaR] mRNA expression . Positive_regulation NR2F1 BMP1 19812316 2148654 signaling is *essential* for the correct dorsoventral spatial expression of [COUP-TFI] and COUP-TFII . Positive_regulation NR2F1 BMP10 19812316 2148662 signaling is *essential* for the correct dorsoventral spatial expression of [COUP-TFI] and COUP-TFII . Positive_regulation NR2F1 BMP15 19812316 2148655 signaling is *essential* for the correct dorsoventral spatial expression of [COUP-TFI] and COUP-TFII . Positive_regulation NR2F1 BMP2 19812316 2148656 signaling is *essential* for the correct dorsoventral spatial expression of [COUP-TFI] and COUP-TFII . Positive_regulation NR2F1 BMP3 19812316 2148657 signaling is *essential* for the correct dorsoventral spatial expression of [COUP-TFI] and COUP-TFII . Positive_regulation NR2F1 BMP4 19812316 2148658 signaling is *essential* for the correct dorsoventral spatial expression of [COUP-TFI] and COUP-TFII . Positive_regulation NR2F1 BMP5 19812316 2148659 signaling is *essential* for the correct dorsoventral spatial expression of [COUP-TFI] and COUP-TFII . Positive_regulation NR2F1 BMP6 19812316 2148660 signaling is *essential* for the correct dorsoventral spatial expression of [COUP-TFI] and COUP-TFII . Positive_regulation NR2F1 BMP7 19812316 2148661 signaling is *essential* for the correct dorsoventral spatial expression of [COUP-TFI] and COUP-TFII . Positive_regulation NR2F1 CCAR2 19112178 2036842 *stabilized* the interaction between [COUP-TFI] and NCoR by interacting directly with both proteins . Positive_regulation NR2F1 FGF1 18625063 1941911 *promotes* [CoupTF1] expression , represses proliferation and promotes neural differentiation . Positive_regulation NR2F1 FGF10 18625063 1941912 *promotes* [CoupTF1] expression , represses proliferation and promotes neural differentiation . Positive_regulation NR2F1 FGF11 18625063 1941913 *promotes* [CoupTF1] expression , represses proliferation and promotes neural differentiation . Positive_regulation NR2F1 FGF12 18625063 1941914 *promotes* [CoupTF1] expression , represses proliferation and promotes neural differentiation . Positive_regulation NR2F1 FGF13 18625063 1941915 *promotes* [CoupTF1] expression , represses proliferation and promotes neural differentiation . Positive_regulation NR2F1 FGF14 18625063 1941916 *promotes* [CoupTF1] expression , represses proliferation and promotes neural differentiation . Positive_regulation NR2F1 FGF16 18625063 1941917 *promotes* [CoupTF1] expression , represses proliferation and promotes neural differentiation . Positive_regulation NR2F1 FGF17 18625063 1941918 *promotes* [CoupTF1] expression , represses proliferation and promotes neural differentiation . Positive_regulation NR2F1 FGF18 18625063 1941919 *promotes* [CoupTF1] expression , represses proliferation and promotes neural differentiation . Positive_regulation NR2F1 FGF19 18625063 1941920 *promotes* [CoupTF1] expression , represses proliferation and promotes neural differentiation . Positive_regulation NR2F1 FGF2 18625063 1941921 *promotes* [CoupTF1] expression , represses proliferation and promotes neural differentiation . Positive_regulation NR2F1 FGF20 18625063 1941922 *promotes* [CoupTF1] expression , represses proliferation and promotes neural differentiation . Positive_regulation NR2F1 FGF21 18625063 1941923 *promotes* [CoupTF1] expression , represses proliferation and promotes neural differentiation . Positive_regulation NR2F1 FGF22 18625063 1941924 *promotes* [CoupTF1] expression , represses proliferation and promotes neural differentiation . Positive_regulation NR2F1 FGF23 18625063 1941925 *promotes* [CoupTF1] expression , represses proliferation and promotes neural differentiation . Positive_regulation NR2F1 FGF3 18625063 1941926 *promotes* [CoupTF1] expression , represses proliferation and promotes neural differentiation . Positive_regulation NR2F1 FGF4 18625063 1941927 *promotes* [CoupTF1] expression , represses proliferation and promotes neural differentiation . Positive_regulation NR2F1 FGF5 18625063 1941928 *promotes* [CoupTF1] expression , represses proliferation and promotes neural differentiation . Positive_regulation NR2F1 FGF6 18625063 1941929 *promotes* [CoupTF1] expression , represses proliferation and promotes neural differentiation . Positive_regulation NR2F1 FGF7 18625063 1941930 *promotes* [CoupTF1] expression , represses proliferation and promotes neural differentiation . Positive_regulation NR2F1 FGF8 18625063 1941931 *promotes* [CoupTF1] expression , represses proliferation and promotes neural differentiation . Positive_regulation NR2F1 FGF9 18625063 1941932 *promotes* [CoupTF1] expression , represses proliferation and promotes neural differentiation . Positive_regulation NR2F1 IFNGR2 9914518 586969 Moreover , this enhancement of transcriptional activation by [COUP-TFI] *requires* specifically the transactivation function of ER and can be observed in the presence of E2 or 4-hydroxytamoxifen but not ICI 164384 . Positive_regulation NR2F1 MOCOS 23785296 2802474 Global gene expression analysis by RNA-seq revealed that in the mouse mammary gland , the orphan nuclear receptor gene [Nr2f1/Coup-tf1] is *regulated* by . Positive_regulation NR2F1 MOCOS 23785296 2802476 Our data suggest that the non-protein coding locus *regulates* [Nr2f1] , which is a candidate modifier of differentiation , proliferation , and mammary cancer risk . Positive_regulation NR2F6 RNASE1 12853122 1110031 The bactericidal activities of mature Ear-1 ( Q ) and mature [Ear-2] ( Q ) were not *inhibited* by inhibitor , but was increased by treatment at 96 degrees C for 20 min . Positive_regulation NR2F6 RNASE7 12853122 1110039 The bactericidal activities of mature Ear-1 ( Q ) and mature [Ear-2] ( Q ) were not *inhibited* by inhibitor , but was increased by treatment at 96 degrees C for 20 min . Positive_regulation NR3C1 EPHB2 23667643 2785003 Viral infection increases glucocorticoid induced interleukin-10 production through *mediated* phosphorylation of the [glucocorticoid receptor] in dendritic cells : potential clinical implications . Positive_regulation NR3C1 FOXA1 22001115 2522167 *promotes* [glucocorticoid receptor (GR)-DNA] binding and transcription . Positive_regulation NR3C1 FOXO1 24971545 2952486 Here we show that upregulation of expression by glucocorticoids *requires* the [glucocorticoid receptor (GR)] and binding of hormones to it . Positive_regulation NR3C1 IL1B 11146166 758911 A total of 14 clones could be matched to known genes and were categorized into four groups : A ) transcription factors : prothymosin , CA150 , p78 serine/threonine kinase , *stimulating* gene , [glucocorticoid receptor] , MLN64/CAB1 , gastrin binding protein , and polypeptide from glioblastoma ; Positive_regulation NR3C1 RNASE1 3790497 66326 Bovine pancreatic and S protein ( enzymatically inactive proteolytic fragment of RNase A which contains RNA binding site ) *stimulate* the activation , as evidenced by increasing DNA-cellulose binding , of highly purified rat hepatic [glucocorticoid-receptor] complexes . Positive_regulation NR3C1 RNASE1 6672455 34252 The present results are consistent with the hypothesis that binder IB is formed in vitro by a process which may not involve proteolytic cleavage or *induced* modification of the [glucocorticoid receptor] ( binder II ) . Positive_regulation NR3C1 RNASE7 6672455 34260 The present results are consistent with the hypothesis that binder IB is formed in vitro by a process which may not involve proteolytic cleavage or *induced* modification of the [glucocorticoid receptor] ( binder II ) . Positive_regulation NR3C1 TNF 8823306 384885 We found that *increased* glucocorticoid induced transcriptional activity of the [glucocorticoid receptor (GR)] via the glucocorticoid response elements ( GRE ) in L-929 mouse fibroblasts transfected with a glucocorticoid-inducible reporter plasmid . Positive_regulation NR3C1 TNF 9435375 474693 We have previously shown that and IL-1 may *enhance* the glucocorticoid ( GC ) -induced transcriptional activity of [glucocorticoid receptor (GR)] in different cell lines transfected with a reporter plasmid carrying GC response elements ( GRE ) . Positive_regulation NR3C2 CTGF 17602195 1815909 is a functional target of aldosterone in mesangial cells , but aldosterone induced CTGF gene expression is not directly *mediated* by the [mineralocorticoid receptor] . Positive_regulation NR3C2 HSD11B2 10620097 576141 This is *caused* by 18betaGA mediated inhibition of <11betaHSD> , resulting in activation of the renal [mineralocorticoid receptor] by cortisol . Positive_regulation NR3C2 HSD11B2 23042946 2698573 Furthermore , inhibition of activity by 18ß-glycyrrhetinic acid *resulted* in elevated whole-body cortisol levels and preoptic area mRNA abundance of corticotropin releasing factor and [mineralocorticoid receptor] . Positive_regulation NR3C2 RNASE1 18691036 1949485 Based on our earlier report that [mixed lymphocyte reactions (MLR)] *induce* a that inhibits HIV-1 replication , we proposed that maternal-fetal alloantigen stimulation activates factors that protect the fetus against vertically transmitted infections . Positive_regulation NR3C2 RNASE7 18691036 1949493 Based on our earlier report that [mixed lymphocyte reactions (MLR)] *induce* a that inhibits HIV-1 replication , we proposed that maternal-fetal alloantigen stimulation activates factors that protect the fetus against vertically transmitted infections . Positive_regulation NR3C2 TLR7 21334039 2404025 A CPXV infection of DCs did not stimulate cytokine or chemokine secretion directly , but suppressed agonist *induced* cytokine secretion and a DC-stimulated [mixed leukocyte reaction (MLR)] . Positive_regulation NR3C2 TNF 7827283 285742 Together these data suggest that the suppression of [MLR] by IL-10 *requires* the effective inhibition of both IL-2 and production to suppress a synergy between these two cytokines . Positive_regulation NR4A1 ANGPT1 22628435 2614768 Both and VEGF *induce* [Nur77] expression , by > 5- and 30-fold , respectively . Positive_regulation NR4A1 CTGF 7593235 334631 [NAK-1] , PAI-1 , and HSP-70 were induced or stimulated only in cells at the wound edge , u-PA was stimulated in cells away from the wound , and was *induced* in each of these populations suggesting that cell-to-cell communication may regulate gene expression after wounding . Positive_regulation NR4A1 EPHB2 22186412 2543379 signaling , but not c-Raf , is *required* for gonadotropin releasing hormone (GnRH) induced regulation of [Nur77] in pituitary gonadotropes . Positive_regulation NR4A1 EPHB2 22186412 2543383 Using a variety of approaches , we show that GnRH induced transcriptional upregulation of [Nur77] in aT3-1 cells is *dependent* on calcium , protein kinase C ( PKC ) , and signaling . Positive_regulation NR4A1 EPHB2 22186412 2543388 These results further clarify the *role* of and PKC signaling in regulation of the GnRH induced immediate early gene program as well as GnRH induced transcription stimulating activity of [Nur77] in the gonadotrope and shed new light on the complex functional organization of this signaling pathway in the pituitary gonadotrope . Positive_regulation NR4A1 FOXO1 22496671 2583709 We report here that , when RE is replaced with four LexA operators in MATa cells , 95 % of cells use [HMR] for repair , but expression of a fusion protein strongly *increases* HML usage . Positive_regulation NR4A1 TNF 12815108 1107670 [Nur77] expression is strongly *induced* by . Positive_regulation NR4A1 TNF 15910281 1445696 The *induction* of [Nur77] by and anisomycin was abolished in MSK1/2 double-knockout cells , whereas induction was significantly reduced in response to PMA or EGF . Positive_regulation NR4A1 TNF 15910281 1445700 Consistent with the decrease in Nur77 mRNA levels in the MSK1/2-knockout cells , it was also found that MSKs were required for the *induction* of [Nur77] protein by PMA and . Positive_regulation NR4A1 TNF 15990085 1429536 RG and PG attenuated *mediated* induction of trans acting factor ( s ) [Nur77/Nurr1] and binding of nuclear proteins ( NP ) to the cis acting element ( NBRE ) . Positive_regulation NR4A1 TNF 18180317 1856487 In addition , GLP-1 attenuated TNF-alpha mediated induction of Nur77 mRNA and *mediated* binding of nuclear proteins (NPs) to the PAI-1 , [Nur77] , cis acting response element nerve growth factor induced clone B response element ( NBRE ) . Positive_regulation NR4A1 TNF 19136619 2047977 In addition , treatment attenuated or hyperglycaemia mediated *induction* of the orphan nuclear receptor [Nur77] mRNA expression . Positive_regulation NR4A2 EPHB2 15106839 1240580 Differential *role* of in cAMP induced [Nurr1] expression in N2A and C6 cells . Positive_regulation NR4A2 EPHB2 19246938 2050813 the inhibitor can partially *block* the translocation of [Nurr1] from the cytoplasm to the nucleus . Positive_regulation NR4A2 FOXA1 17596284 1768249 Subsequently , and Foxa2 *regulate* the expression of [Nurr1] ( Nr4a2 ) and engrailed 1 in immature neurons and the expression of aromatic l-amino acid decarboxylase and tyrosine hydroxylase in mature neurons during early and late differentiation of midbrain dopaminergic neurons . Positive_regulation NR4A2 IL1B 19544469 2128852 Surprisingly , IL-1beta did not activate the NF-kappaB pathway or the transcription factor activating protein 1 (AP-1) , but inhibition of nuclear translocation of NF-kappaB by SN50 facilitated *induced* [Nurr1] expression and dopaminergic differentiation of mdNPCs . Positive_regulation NR4A2 STK39 15485875 1342663 Receptor tyrosine kinase activators had minimal effect , whereas activators *had* no effect on basal [Nurr1] mRNA levels . Positive_regulation NR4A2 TNF 15990085 1429537 RG and PG attenuated *mediated* induction of trans acting factor ( s ) [Nur77/Nurr1] and binding of nuclear proteins ( NP ) to the cis acting element ( NBRE ) . Positive_regulation NR4A2 TNF 19732956 2147099 Transcriptional effects of NR4A2 on the human IL-8 promoter are enhanced in the *presence* of , suggesting molecular crosstalk between TNF-alpha signalling and [NR4A2] . Positive_regulation NR4A2 TNF 20407282 2267573 IL-1beta , IL-6 and *stimulated* the nuclear expression levels of NF-kappaB , NF-kappaB dependent [Nurr1] and c-Fos proteins . Positive_regulation NR5A1 EPHB2 11410589 849746 We demonstrate that cyclic AMP induced steroid synthesis is dependent upon the phosphorylation and activation of ERKs and that activation *results* in enhanced phosphorylation of [SF-1] and increased steroid production through increased transcription of the StAR gene . Positive_regulation NR5A1 EPHB2 11410589 849758 These effects were attributed to the finding that activity is *required* for [SF-1] phosphorylation , a transcription factor required for the regulation of StAR gene transcription . Positive_regulation NR5A1 EPHB2 11410589 849759 This conclusion was supported by our demonstration of an *dependent* increase in the binding of [SF-1] from FSK treated Y1 nuclei to three consensus double stranded DNA sequences from the StAR promoter region . Positive_regulation NR5A1 EPHB2 18004794 1894552 The results suggested that ( 1 ) ERK pathway of rat ZFR cells might be PKA dependent , ( 2 ) activity was *required* for [SF-1] phosphorylation to upregulate steroidogenesis in rat ZFR cells , and ( 3 ) DHEA did not affect ERK phosphorylation , however , it attenuated forskolin stimulated SF-1 phosphorylation to affect StAR protein expression . Positive_regulation NR5A1 NES 18951950 2034809 Mice with CNS-specific knockout of [SF-1] *mediated* by showed increased anxiety-like behavior , revealing a crucial role of SF-1 in a complex behavioral phenotype . Positive_regulation NR5A2 TNF 12837754 1134697 These results indicate that induction of Mrp3 after BDL is due to *dependent* up-regulation of [Lrh-1] . Positive_regulation NRARP NOTCH1 15325262 1287110 Interestingly , increased [Nrarp] transcription was *observed* following induction of signaling , suggesting the existence of a negative feedback loop . Positive_regulation NRARP NOTCH1 19056690 2047430 High activity *increases* DTX1 , [NRARP] , and RUNX3 expression , genes that are down-regulated during alphabeta-lineage differentiation . Positive_regulation NRARP NOTCH2 15325262 1287111 Interestingly , increased [Nrarp] transcription was *observed* following induction of signaling , suggesting the existence of a negative feedback loop . Positive_regulation NRARP NOTCH2 19056690 2047431 High activity *increases* DTX1 , [NRARP] , and RUNX3 expression , genes that are down-regulated during alphabeta-lineage differentiation . Positive_regulation NRARP NOTCH3 15325262 1287112 Interestingly , increased [Nrarp] transcription was *observed* following induction of signaling , suggesting the existence of a negative feedback loop . Positive_regulation NRARP NOTCH3 19056690 2047432 High activity *increases* DTX1 , [NRARP] , and RUNX3 expression , genes that are down-regulated during alphabeta-lineage differentiation . Positive_regulation NRARP NOTCH4 15325262 1287113 Interestingly , increased [Nrarp] transcription was *observed* following induction of signaling , suggesting the existence of a negative feedback loop . Positive_regulation NRARP NOTCH4 19056690 2047433 High activity *increases* DTX1 , [NRARP] , and RUNX3 expression , genes that are down-regulated during alphabeta-lineage differentiation . Positive_regulation NRAS AGR2 8021500 263077 These events may be important for *activation* of [Ras] by the . Positive_regulation NRAS ANGPT1 12039842 954288 Accordingly , ephrinB2 inhibited VEGF- and *induced* [Ras-MAPK] activities , whereas ephrinB2 did not alter VEGF induced Flk phosphorylation or Ang1 induced Tie2 phosphorylation . Positive_regulation NRAS CCND1 11223027 787812 Thus , [Ras] activity during G2 phase *induces* expression . Positive_regulation NRAS CCND1 12429909 1015097 These studies were designed to understand how [Ras] could *induce* levels only during G2 phase . Positive_regulation NRAS CTGF 15855807 1425625 TGF-beta1 induced connective tissue growth factor ( ) expression in human renal proximal tubule epithelial cells *requires* [Ras/MEK/ERK] and Smad signalling . Positive_regulation NRAS EDN2 17707940 1800763 Endothelin stimulated protein kinase C ( PKC ) was partially inhibited by both YM-254890 and pertussis toxin , while only pertussis toxin attenuated induced [Ras] *activation* . Positive_regulation NRAS EPHB2 10898494 712067 Here , we analyzed the effects of Vav on three known downstream targets of [Ras] , i. e. *activation* of and NFAT , and up-regulation of the activation antigen CD69 . Positive_regulation NRAS EPHB2 10978313 751958 Whereas the essential *roles* of and JNK in [Ras] signaling has been established , the contribution of p38 remains unclear . Positive_regulation NRAS EPHB2 11018025 752782 Expression of a dominant negative mutant of Ras also did not significantly impair calcium induced ERK activation , indicating that calcium mediated activation does not *require* active [Ras] . Positive_regulation NRAS EPHB2 11088001 764967 We show that the activation of via SSTR1 is mediated by the betagamma subunit of a pertussis toxin-sensitive G-protein and *requires* both the small G protein [Ras] and the serine/threonine kinase Raf-1 . Positive_regulation NRAS EPHB2 11574537 882428 NT-stimulated activity *requires* [Ras] activation because overexpression of the dominant negative Ras mutant Ras-17N almost completely inhibits the Erk activation . Positive_regulation NRAS EPHB2 12364324 1019155 GLP1 stimulated activation of is blocked by inhibitors of MEK , but GLP1 does not *induce* the activation of A-Raf , B-Raf , C-Raf , or [Ras] . Positive_regulation NRAS EPHB2 12902401 1121128 LPA induced chemotaxis is markedly dependent on activation of PTX-sensitive heterotrimeric G-proteins , on activation of the small GTPases [Ras] , Rac and RhoA , and on GTPase dependent *activation* of . Positive_regulation NRAS EPHB2 15205467 1281174 Thus , unlike galectin-1 , which prolongs [Ras] *activation* of and inhibits PI3-K , K-Ras-GTP/galectin-3 interactions promote , in addition to PI3-K and Raf-1 activation , a third inhibitory signal that attenuates active ERK . Positive_regulation NRAS EPHB2 15650750 1364060 Influx of calcium , mediated either by L-type voltage-sensitive calcium channels or glutamate receptors , is associated with the suppression of brain derived neurotrophic factor (BDNF) *activation* of [Ras] and its effectors and Akt . Positive_regulation NRAS EPHB2 16436505 1540516 In addition , we demonstrated that Tat activation of [Ras] , but not of Rac , *induces* phosphorylation . Positive_regulation NRAS EPHB2 20176802 2222131 [Ras] *activation* of restores impaired tonic BCR signaling and rescues immature B cell differentiation . Positive_regulation NRAS EPHB2 20639215 2322046 We found that phosphorylation of this receptor contributed to [Ras] and ERK activation and that inhibition of , PKC , and EGFR *blocked* the mitogenic response induced by sPLA ( 2 ) -IIA . Positive_regulation NRAS EPHB2 21330403 2420302 Measurements of the dephosphorylation of and the *activation* of [Ras] showed that the ROS scavenger prevents the cAMP provoked activation of Ras and that cAMP , with or without a ROS scavenger , has little or no effect on the dephosphorylation of ERK . Positive_regulation NRAS EPHB2 21771815 2456804 [Ras] continues to promote subsequent aspects of duct morphogenesis and differentiation , and *acts* primarily through and the transcriptional effectors LIN-1/Ets and EOR-1 . Positive_regulation NRAS EPHB2 21949793 2488029 Like costimulation via CD28 , active [Ras] *induced* AKT , JNK and phosphorylation . Positive_regulation NRAS EPHB2 22258408 2544917 We observed that loss of mitochondrial genome reversibly *induced* overexpression and activation of proto-oncogenic [Ras] , especially K-Ras 4A , responsible for the activation of AKT and leading to advanced phenotype of prostate and breast cancer . Positive_regulation NRAS EPHB2 22687285 2643699 *activation* of [RAS] signaling to LKB1 and RASGRP3 , via and p90RSK , might be involved in liver carcinogenesis and be used as a prognostic marker . Positive_regulation NRAS EPHB2 9234703 445396 [Ras] *activation* of was inhibited by both Pak1 ( R299 ) and Pak1 ( L83,L86,R299 ) , while neither mutant inhibited Raf activation of ERK . Positive_regulation NRAS EPHB2 9556628 499868 A dominant negative form of RHAMMv4 inhibits mutant active [Ras] *activation* of and coimmunoprecipitates with both mitogen activated protein kinase kinase and ERK , suggesting that the intracellular RHAMMv4 acts downstream of Ras , possibly at the level of mitogen activated protein kinase kinase-ERK interactions . Positive_regulation NRAS EPHB2 9892010 586568 We show that the activation of via SSTR1 is pertussis toxin sensitive and *requires* the small G protein [Ras] , phosphatidylinositol 3-kinase , the serine/threonine kinase Raf-1 , and the protein tyrosine phosphatase SHP-2 . Positive_regulation NRAS FAS 9240472 445945 Osmotic cell shrinkage did not interfere with *induced* activation of the acidic sphingomyelinase or activation of [Ras] but impaired the formation of O2 suggesting an important function of cell volume in the synthesis of reactive oxygen intermediates upon Fas receptor ligation . Positive_regulation NRAS FHL1 23456229 2781825 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Positive_regulation NRAS GPR115 9020193 413029 A scaffold for mediated [Ras] *activation* . Positive_regulation NRAS GPR132 9020193 413018 A scaffold for mediated [Ras] *activation* . Positive_regulation NRAS GPR87 9020193 413098 A scaffold for mediated [Ras] *activation* . Positive_regulation NRAS ITGB2 17624948 1770115 We have recently shown that Ras is also downstream of LFA-1 engagement : signaling through phospholipase D (PLD) to RasGRP1 was *required* for [Ras] activation on the plasma membrane following stimulation of TCR . Positive_regulation NRAS MAP2K6 10442634 635731 Finally , while Rlf-CAAX does not increase Erk activity , inhibition of *blocks* both [Ras-] as well as Rlf-CAAX induced differentiation , suggesting that RalGEFs induce PrE differentiation in a manner depending on basal MEK or Erk activity . Positive_regulation NRAS MAP2K6 10978313 751994 was *required* for [Ras] stimulation of the p38 pathway . Positive_regulation NRAS MAP2K6 12411397 1010770 PE and ET-1 do not activate protein kinase B but stimulate [Ras] and Erk , and their ability to activate protein synthesis was *blocked* by inhibition of Ras or and by rapamycin , which inhibits mTOR ( mammalian target of rapamycin ) . Positive_regulation NRAS MAP2K6 19022560 2029239 Furthermore , *activation* of Raf-1 , and the ERKs by either EGF or [Ras] ( G12R ) was inhibited by NM23H2 overexpression . Positive_regulation NRAS MAP2K6 23546290 2763098 Second , farnesyltransferase inhibitor I , a [Ras] *inhibitor* , and U0126 , a inhibitor , induced an inhibition of the cell proliferation in C6 cells , while the cell proliferation was inhibited by nobiletin as well . Positive_regulation NRAS MAP2K6 8182145 256520 One of these pathways involves the activation of [Ras] , leading to the activation of Raf-1 , and the subsequent *activation* of ( MAPK or ERK kinase ) . Positive_regulation NRAS MAP2K6 9135066 427706 Moreover , inhibition of endogenous by a specific inhibitor , PD 098059 , *suppressed* the activation of p96h2bk by oncogenic [Ras] . Positive_regulation NRAS NGFR 8108130 246109 We have previously shown that nerve growth factor (NGF) induces a rapid and relatively continuous activation of Ras in rat pheochromocytoma PC12 cells while epidermal growth factor (EGF) activates Ras transiently , and that tyrosine kinase activity of the is *essential* for the activation of [Ras] ( Muroya et al. , Oncogene , 7 , 277-281 , 1992 ) . Positive_regulation NRAS S100B 21209080 2391865 The *dependent* activation of diaphanous-1/Rac1/JNK/AP-1 , Ras/Rac1/NF-?B and [Src/Ras/PI3K/RhoA/diaphanous-1] results in the up-regulation of expression of the chemokines , CCL3 , CCL5 , and CXCL12 , whose release and activity are required for S100B to stimulate microglia migration . Positive_regulation NRAS SELL 8986819 404100 Stimulation of the Ras pathway by L-selectin requires functional p56lck , since p56lck-deficient Jurkat cells ( JCaM1.6 ) do not show tyrosine phosphorylation , association of with Grb2/Sos , and *activation* of [Ras] upon L-selectin triggering . Positive_regulation NRAS TNF 12600818 1085045 treatment *induced* both [Ras] and MEKK1 activation . Positive_regulation NRAS TNF 14999690 1216810 In conclusion , these data support the hypotheses that hepatocellular oxidative stress leads to cell death and that *induced* [Ras] activation is important in hepatic proliferation in response to ethanol induced liver injury . Positive_regulation NRAS TNF 17059425 1683929 Zoledronate reduced Ras prenylation , [Ras] and RhoA translocation to the membrane , and sustained ERK1/2 phosphorylation and *induced* JNK phosphorylation . Positive_regulation NRAS TNF 17994109 1851170 triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* [Ras] , p38 MAPK , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation NRAS TNF 18310456 1879065 Simvastatin potently suppressed TNF-alpha induced phosphorylation of ERK1/2 and SAPK/JNK by inhibiting *induced* membrane localization of [Ras] and RhoA . Positive_regulation NRAS TNF 21938476 2532761 With 4-MC pretreatment to hyperglycemic rats the following results were noted : ( i ) Decrease in pancreatic NGF level was blocked , ( ii ) Increase in pancreatic TNF-a level and the number of ( + ) beta cell in the islets were prevented , ( iii ) *Increase* in the number of ß cell synthhesized apoptotic [Ras] effectors that RASSF1 and NORE1 was blocked , ( iv ) While pancreatic lipid peroxidation level decreased , antioxidant molecule glutathione and antioxidant enzymes glutathione peroxidase , catalase and superoxide dismutase activities increased , ( v ) Pancreatic caspase-3 activity and the number of cleaved caspase-3 ( + ) ß cells were decreased . Positive_regulation NRF1 PGC 24140059 2863933 The activation of *led* to increased mRNA levels of mitochondrial transcription factor A ( Tfam ) and [nuclear related factor 1(Nrf1)] , these changes were accompanied by increases in mitochondrial DNA copy number and complex protein levels , while activation of Nrf2 increased levels of phase II detoxifying enzymes , including nicotinamide adenine dinucleotide phosphate : quinone oxidoreductase 1 ( NQO1 ) , superoxide dismutase ( MnSOD ) and catalase . Positive_regulation NRG1 CTGF 22350758 2586826 [Neuregulin] *induces* expression in hypertrophic scarring fibroblasts . Positive_regulation NRG1 EPHB2 17085783 1643756 [NRG] *induces* prolonged activation of PKB/Akt and . Positive_regulation NRG1 EPHB2 21898395 2554625 After ErbB4 cleavage , the *activation* of by [neuregulin 1] was almost completely inhibited . Positive_regulation NRG2 CTGF 22350758 2586827 [Neuregulin] *induces* expression in hypertrophic scarring fibroblasts . Positive_regulation NRG2 EPHB2 17085783 1643760 [NRG] *induces* prolonged activation of PKB/Akt and . Positive_regulation NRG3 CTGF 22350758 2586828 [Neuregulin] *induces* expression in hypertrophic scarring fibroblasts . Positive_regulation NRG3 EPHB2 17085783 1643764 [NRG] *induces* prolonged activation of PKB/Akt and . Positive_regulation NRG4 CTGF 22350758 2586825 [Neuregulin] *induces* expression in hypertrophic scarring fibroblasts . Positive_regulation NRG4 EPHB2 17085783 1643736 [NRG] *induces* prolonged activation of PKB/Akt and . Positive_regulation NRIP1 FHL1 19401155 2070360 Overexpression of *enhanced* [RIP140] repression of estrogen signaling in breast cancer cells in a reporter assay , whereas reduction of endogenous FHL1 with FHL1 small interfering RNA abolished this effect . Positive_regulation NRIP1 FHL1 19401155 2070361 Furthermore , overexpression of the deletion mutant that lacks the RIP140 binding sites *had* no effect on [RIP140] repression of estrogen signaling . Positive_regulation NRK IL1B 18975157 478900 CINC-1 induction in *stimulated* rat fibroblast [NRK-49F] cells was quantitated by a sensitive ELISA . Positive_regulation NRK IL1B 8471066 216164 The anti-inflammatory steroids ( dexamethasone , prednisolone and hydrocortisone ) at 10 ( -9 ) -10 ( -6 ) M significantly suppressed the production of rat gro/CINC by the *stimulated* [NRK-49F] cells in a dose dependent manner . Positive_regulation NRP1 HBEGF 16330548 1512018 Epidermal growth factor (EGF) and ( HB-EGF ) strongly *up-regulated* [NRP1] expression , concomitant with down-regulation of NRSF . Positive_regulation NRP1 MAOA 24865426 2945522 dependent *activation* of [neuropilin-1] promoted AKT/FOXO1/TWIST1 signaling , allowing FOXO1 binding at the TWIST1 promoter . Positive_regulation NRP1 OXTR 16014624 1453124 showed high affinity binding to VEGF165 ( Kd = 2.2 nm ) , as compared with heparin ( Kd = 15 nm ) , and *potentiated* the affinity of VEGF165 for VEGF receptor-1 and -2 and for [neuropilin-1] . Positive_regulation NRP1 TNF 12613541 1030019 [NRP1] expression is *regulated* in EC by , the transcription factors dHAND and Ets-1 , and vascular injury . Positive_regulation NRP1 TNF 9705358 526021 *regulates* expression of vascular endothelial growth factor receptor-2 and of its co-receptor [neuropilin-1] in human vascular endothelial cells . Positive_regulation NRP2 IL1B 22853041 2682387 *upregulates* brain derived neurotrophic factor , neurotrophin 3 and [neuropilin 2] gene expression and NGF production in annulus cells . Positive_regulation NRTN TNF 12960779 1138491 Lipopolysaccharide and *regulate* the expression of GDNF , [neurturin] and their receptors . Positive_regulation NT5C CFI 17538026 1773223 Like Net1/Cfi1 , [Dnt1] is required for rDNA silencing and minichromosome maintenance , and both Dnt1 and negatively *regulate* the homologous SIN and MEN pathways . Positive_regulation NT5E ACPP 1557611 184483 The decreased [ecto-5'-NT] activity of BMC from patients with immunodeficiency may thus be *due* to a defective regulation of activity in vivo . Positive_regulation NT5E ADA 2541427 110493 Adenosine metabolism in hypothyrosis has been shown to decrease in thymocytes ( [5'-nucleotidase] activity decreases by 18 % and activity *increases* in thymocyte light fractions ) . Positive_regulation NT5E ADA 2842422 95383 Following an initial time lag of 24 h , mean activity from seven separate experiments as measured in nmoles/10 ( 6 ) cells/h *increased* from a baseline of 31.3 +/- 9.3 to 57.8 +/- 16.4 ( P less than 0.005 ) at 72 h and to 72 +/- 21.5 ( P less than .025 ) by 96 h . [5NT] activity increased from a baseline of 2.2 +/- 0.9 to a maximum of 44 +/- 10.1 by 72 h and then declined to 29 +/- 18 ( P less than 0.005 ) by 96 h , while no significant change in PNP activity was observed . Positive_regulation NT5E ADA 9933023 589198 Erythro-9- ( 2-hydroxy-3-nonyl ) adenine ( 10 microM ) , an inhibitor of , and alpha , beta-methyleneadenosine 5'-diphosphate ( 100 microM ) , an *inhibitor* of [ecto-5'-nucleotidase] , did not alter forskolin activity . Positive_regulation NT5E ATP5O 6135422 29076 Acetaldehyde produced non-competitive inhibition of ( Na+K+ ) and Mg2+ ATPase at concentrations of 6 and 56 mM respectively and [5' nucleotidase] activity was also *inhibited* at these concentrations . Positive_regulation NT5E BRAP 17693717 1782074 One of the genes , aphA , encoded a [5'-nucleotidase] activity and was *induced* by or inosine . Positive_regulation NT5E CASR 20684246 2299148 It was established , that apyrase and [5'-nucleotidase] activities decreased and adenosine deaminase activity *increased* in platelets of the rats with . Positive_regulation NT5E CD38 10229870 611244 The aim of this study was 2-fold : first , to characterize the mechanisms by which *regulates* [CD73] expression ; Positive_regulation NT5E DCE 3787626 66303 DSF alone did not elicit these responses while at the highest concentration level *increased* liver-to-body weight ratios and the activity of [5'-nucleotidase] . Positive_regulation NT5E EGF 9851317 554370 In contrast , genistein ( 10 mg x ml(-1) ) , an inhibitor of tyrosine kinase , prevented *dependent* stimulation of aminopeptidase N and [5'-nucleotidase] , suggesting that protein phosphorylation was involved in the signaling mechanism . Positive_regulation NT5E ESR1 14760094 1206879 *Role* of in the regulation of [ecto-5'-nucleotidase] and adenosine in breast cancer . Positive_regulation NT5E HIF1A 12370277 995690 Examination of the CD73 gene promoter identified at least one binding site for hypoxia-inducible factor-1 (HIF-1) and inhibition of expression by antisense oligonucleotides *resulted* in significant inhibition of hypoxia-inducible [CD73] expression . Positive_regulation NT5E HPSE 10545017 564210 In this study , we demonstrated that nerve growth factor (NGF) , the prototypic NT , and [NT-4/5] increased in vitro invasion through a reconstituted basement membrane and *induced* time- and dose dependent expression of , a heparan sulfate-specific endo-beta-D-glucuronidase , an important molecular determinant of tumor metastasis . Positive_regulation NT5E IFNB1 18034430 1832565 also *induced* the expression and activity of [CD73] and concurrently decreased vascular permeability in cultured human pulmonary endothelial cells . Positive_regulation NT5E IFNB1 18825744 1981589 *regulates* [CD73] and adenosine expression at the blood-brain barrier . Positive_regulation NT5E IFNB1 18825744 1981591 *increases* the expression of [ecto-5'-nucleotidase] both on BBB-EC and astrocytes . Positive_regulation NT5E IFNB1 24503265 2914100 In ex-vivo studies , we first established that *induced* [CD73] up-regulation in cultured human lung tissue samples . Positive_regulation NT5E IL1B 2165999 137868 and TNF-alpha *stimulated* mesangial cell [5'-nucleotidase] activity in a dose dependent manner after treatment for 24 hr. Maximum increases reached 4.5 times and 1.7 times basal values for IL-1 beta ( 20 U/ml ) and TNF-alpha ( 25 ng/ml ) , respectively . Positive_regulation NT5E IL1B 2165999 137870 *Stimulation* of [5'-nucleotidase] by and TNF-alpha was specific since the activity of other ectoenzymes , such as Mg2 ( + ) -ATPase , was unchanged . Positive_regulation NT5E MCM2 2550695 117613 In addition , produced a dose dependent *increase* of mesangial cell [ecto-5'-nucleotidase] activity . Positive_regulation NT5E MCM2 2550695 117626 *Stimulation* of [ecto-5'-nucleotidase] activity by was inhibited by cycloheximide , which suggests that protein synthesis was required . Positive_regulation NT5E MCM3 2550695 117614 In addition , produced a dose dependent *increase* of mesangial cell [ecto-5'-nucleotidase] activity . Positive_regulation NT5E MCM3 2550695 117627 *Stimulation* of [ecto-5'-nucleotidase] activity by was inhibited by cycloheximide , which suggests that protein synthesis was required . Positive_regulation NT5E MCM4 2550695 117615 In addition , produced a dose dependent *increase* of mesangial cell [ecto-5'-nucleotidase] activity . Positive_regulation NT5E MCM4 2550695 117628 *Stimulation* of [ecto-5'-nucleotidase] activity by was inhibited by cycloheximide , which suggests that protein synthesis was required . Positive_regulation NT5E MCM5 2550695 117616 In addition , produced a dose dependent *increase* of mesangial cell [ecto-5'-nucleotidase] activity . Positive_regulation NT5E MCM5 2550695 117629 *Stimulation* of [ecto-5'-nucleotidase] activity by was inhibited by cycloheximide , which suggests that protein synthesis was required . Positive_regulation NT5E MCM6 2550695 117617 In addition , produced a dose dependent *increase* of mesangial cell [ecto-5'-nucleotidase] activity . Positive_regulation NT5E MCM6 2550695 117630 *Stimulation* of [ecto-5'-nucleotidase] activity by was inhibited by cycloheximide , which suggests that protein synthesis was required . Positive_regulation NT5E MCM7 2550695 117618 In addition , produced a dose dependent *increase* of mesangial cell [ecto-5'-nucleotidase] activity . Positive_regulation NT5E MCM7 2550695 117631 *Stimulation* of [ecto-5'-nucleotidase] activity by was inhibited by cycloheximide , which suggests that protein synthesis was required . Positive_regulation NT5E MCOLN1 15478804 1319764 Expression in Pichia pastoris resulted in the secretion of an active enzyme with the catalytic properties of both a *dependent* diphosphohydrolase/apyrase and a [5'-nucleotidase] . Positive_regulation NT5E MCOLN1 6112213 15181 Using electron microscope cytochemistry and cells separated on Ficoll-Hypaque , *dependent* ATPase , ADPase and [5'-nucleotidase] were predominantly localized as ectoenzymes on normal human granulocytes . Positive_regulation NT5E MCOLN1 9575796 502675 Analysis of all known substrates , products , activators , and inhibitors of the 5'-NT suggests that [5'-NT] is *activated* primarily by and ADP and is inhibited by H+ . Positive_regulation NT5E NR4A1 16271703 1479253 In dogs , IP procedure decreased IS and *activated* [ecto-5'-nucleotidase] , both of which were mimicked by transient exposure to either cromakalim or diazoxide , and these effects were blunted by either GF109203X ( a PKC inhibitor ) or 5-hydroxydecanoate ( a mitoK ( ATP ) channel blocker ) , but not by ( a surface sarcolenmal K ( ATP ) channel blocker ) . Positive_regulation NT5E PRKCA 9345290 459367 *Role* of in activation of [ecto-5'-nucleotidase] in the preconditioned canine myocardium . Positive_regulation NT5E SETD2 21057730 2344657 [CD73] activity is primarily regulated at the level of transcription in *response* to the oxygen sensing transcription factor , and its tissue-specific expression correlates negatively with oxygen tension . Positive_regulation NT5E SETD2 21057730 2344659 *dependent* induction of [CD73] contributes to the protective effects of hypoxia in the inflamed intestinal mucosa . Positive_regulation NT5E SLPI 12712698 581635 The activity of was decreasing with growing , and the activity of [5'-NT] was *increased* with growing . Positive_regulation NT5E TG 6094284 42945 In the serum-free culture , in which TSH was administered to well reformed follicles , this increase in [5'-nucleotidase] activity concerns both the ecto-enzymic and intracellular forms of the enzyme and it coincides with the period of several days during which several glycosyltransferase activities are elevated and production *increased* . Positive_regulation NT5E TNF 2165999 137867 IL-1 beta and *stimulated* mesangial cell [5'-nucleotidase] activity in a dose dependent manner after treatment for 24 hr. Maximum increases reached 4.5 times and 1.7 times basal values for IL-1 beta ( 20 U/ml ) and TNF-alpha ( 25 ng/ml ) , respectively . Positive_regulation NT5E TNF 2165999 137869 *Stimulation* of [5'-nucleotidase] by IL-1 beta and was specific since the activity of other ectoenzymes , such as Mg2 ( + ) -ATPase , was unchanged . Positive_regulation NT5E XDH 14623316 1169351 deactivated both NOS and ecto-5(')-nucleotidase , and amlodipine *increased* both activities of NOS and [ecto-5(')-nucleotidase] by 117+/-33 % and 48+/-6 % , respectively . Positive_regulation NTAN1 SELL 9254657 447684 PLN HEV adhesion was also critically dependent on peripheral lymph node vascular addressins ( PNAds ) , but lymphocyte was absolutely *required* for [PNAd] binding . Positive_regulation NTF3 CAPN8 22580607 2757131 Spheroidgenesis and lymphovascular emboli formation are the direct result of *mediated* cleavage of E-cad and the generation of [E-cad/NTF1] from membrane associated E-cad rather than the de novo presence of either E-cad/NTF1 or E-cad/CTF1 . Positive_regulation NTF3 HRH1 15167971 1253498 Activation of *enhances* [neurotrophic factor] secretion from cultured astrocytes . Positive_regulation NTF3 IL1B 16670534 1558555 The [neurotrophic factor] secretion could be *stimulated* by , tumor necrosis factor-alpha , and lipopolysaccharides in a time- and dose dependent manner . Positive_regulation NTF3 IL1B 22853041 2682388 *upregulates* brain derived neurotrophic factor , [neurotrophin 3] and neuropilin 2 gene expression and NGF production in annulus cells . Positive_regulation NTF3 NT5E 11536331 855215 BDNF and *induced* the dimers , whereas [NT-3] formed slight dimers but NGF did not . Positive_regulation NTF3 SPHK1 9278531 451383 Nerve growth factor (NGF) , a [neurotrophic factor] for pheochromocytoma PC12 cells , *induced* a biphasic increase in the activity of , the enzyme that catalyzes the formation of SPP . Positive_regulation NTF3 TLR7 22499581 2618292 Eicosanoid receptor subtype mediated opposing regulation of *stimulated* expression of astrocyte glial derived [neurotrophic factor] . Positive_regulation NTF3 TNF 16670534 1558554 The [neurotrophic factor] secretion could be *stimulated* by IL-1beta , , and lipopolysaccharides in a time- and dose dependent manner . Positive_regulation NTF4 CAPN8 22580607 2757145 Spheroidgenesis and lymphovascular emboli formation are the direct result of *mediated* cleavage of E-cad and the generation of [E-cad/NTF1] from membrane associated E-cad rather than the de novo presence of either E-cad/NTF1 or E-cad/CTF1 . Positive_regulation NTN1 ITGB2 8097379 217639 In light of the ability of CD18 integrins to participate in leukocyte adherence ( and thereby migration ) , we examined the *role* of the integrin in [NTN] using OX42 , a monoclonal antibody directed against rat CD11b . Positive_regulation NTN1 TNF 22915753 2683079 RNAi mediated attenuation of Tnfrsf1b decreased *induced* [netrin-1] production and augmented epithelial cell apoptosis in culture . Positive_regulation NTN1 UNC5B 15729359 1396330 In the absence of [netrin-1] , *reduces* DAP-kinase autophosphorylation on Ser308 and increases the catalytic activity of the kinase while netrin-1 blocks UNC5H2 dependent DAP-kinase activation . Positive_regulation NTN1 UNC5B 17908930 1803363 *Activation* of the receptor by [Netrin-1] inhibits sprouting angiogenesis . Positive_regulation NTN3 ITGB2 8097379 217641 In light of the ability of CD18 integrins to participate in leukocyte adherence ( and thereby migration ) , we examined the *role* of the integrin in [NTN] using OX42 , a monoclonal antibody directed against rat CD11b . Positive_regulation NTN4 ITGB2 8097379 217635 In light of the ability of CD18 integrins to participate in leukocyte adherence ( and thereby migration ) , we examined the *role* of the integrin in [NTN] using OX42 , a monoclonal antibody directed against rat CD11b . Positive_regulation NTN5 ITGB2 8097379 217637 In light of the ability of CD18 integrins to participate in leukocyte adherence ( and thereby migration ) , we examined the *role* of the integrin in [NTN] using OX42 , a monoclonal antibody directed against rat CD11b . Positive_regulation NTRK1 ANGPT1 19875484 2187906 The antiangiogenic growth factor angiopoietin-2 (Ang-2) antagonizes , whereas *activates* the endothelial cell-specific [tyrosine kinase receptor-2 (Tie-2)] . Positive_regulation NTRK1 CTGF 15601748 1361745 Connective tissue growth factor interacts with and *activates* the tyrosine kinase receptor [TrkA] . Positive_regulation NTRK1 CTGF 22586581 2643399 Hyperglycemia causes renal cell damage via *induced* activation of the [TrkA] receptor : implications for diabetic nephropathy . Positive_regulation NTRK1 EPHB2 15890337 1411500 These data suggest a distinct requirement for CSK in the regulation of [NGF/TrkA] *activation* of RAS , RAC , , and AKT via the differential control of SFKs in the orchestration of neuronal differentiation . Positive_regulation NTRK1 EPHB2 18299325 1903881 Importantly , proNGF activates [TrkA] tyrosine phosphorylation , *induces* and Akt activation , and causes PC12 cell differentiation . Positive_regulation NTRK1 EPHB2 18758136 1968965 Analysis of the common features of the augmented pathways suggests that [TrkA] is most likely to be the primary target of MCC-257 and that both and Akt may be *involved* in the cellular effects of this compound . Positive_regulation NTRK1 IL1B 19177265 2061157 FACS studies showed that unstimulated FLS expressed low levels of NGF and the high-affinity NGF-tyrosine kinase receptor TrkA , and TNFalpha and *increased* NGF and [TrkA] expression in FLS . Positive_regulation NTRK1 NGFR 8253850 238398 The failure of [trkA] to result in an NGF promoted survival response in ciliary neurons is not *due* to absence of the low-affinity , p75 , in these neurons . Positive_regulation NTRK1 TNF 14611111 1162780 NGF , but not IL-1 beta , and CCK-8 , *enhances* the expression of [TrkA] in isolated synovial cells . Positive_regulation NTRK1 TNF 19177265 2061156 FACS studies showed that unstimulated FLS expressed low levels of NGF and the high-affinity NGF-tyrosine kinase receptor TrkA , and and IL-1beta *increased* NGF and [TrkA] expression in FLS . Positive_regulation NTRK2 EPHB2 12504600 1026941 These data suggest that BDNF , once released with activity from primary afferent nociceptors , exerts a neuromodulatory role in pain processing through stimulation of postsynaptic [TrkB] receptors and subsequent *activation* of . Positive_regulation NTRK2 EPHB2 21411668 2404882 Levels of the pan-neurotrophin receptor p75(NTR) and the BDNF receptor TrkB ( tropomyosin receptor kinase B ) are not significantly altered in these synaptoneurosomes , but phosphorylation of [TrkB] and downstream *activation* of PLC?1 ( phospholipase C?1 ) and ( extracellular response kinase ) are attenuated-observations consistent with reduced availability of mature BDNF to activate TrkB signaling . Positive_regulation NTRK2 EPHB2 24530412 2924315 It is noteworthy that a tyrosine kinase receptor inhibitor , K252a , an inhibitor ( U0126 ) , and a PI3Kinase-Akt inhibitor ( LY294002 ) remarkably *attenuated* [TrkB] , ERK , and Akt phosphorylation as well as increase of OPN mRNA expression in the HCEM cells , respectively . Positive_regulation NTRK2 MAP2K6 24530412 2924324 It is noteworthy that a tyrosine kinase receptor inhibitor , K252a , an inhibitor ( U0126 ) , and a PI3Kinase-Akt inhibitor ( LY294002 ) remarkably *attenuated* [TrkB] , ERK , and Akt phosphorylation as well as increase of OPN mRNA expression in the HCEM cells , respectively . Positive_regulation NTS PLAU 9428741 474309 To investigate if [neurotensin (NT)] could *induce* activation of ( uPA ) in vascular endothelial cells , we utilized the acetyl-NT ( 8-13 ) analogue , TJN-950 , in which the C-terminal leucine is reduced to leucinol . Positive_regulation NTS TNF 1372239 182932 Interleukin-1 alpha and differentially *regulate* enkephalin , vasoactive intestinal polypeptide , [neurotensin] , and substance P biosynthesis in chromaffin cells . Positive_regulation NTSR1 EPHB2 20663927 2305275 The purpose of our current study was to determine : ( a ) whether HDACi alters NTR1 expression and function , and ( b ) the *role* of in [NTR1] regulation . Positive_regulation NTSR1 EPHB2 20663927 2305280 Selective kinase/ERK inhibitors *suppressed* [NTR1] mRNA expression in a time- and dose dependent fashion , and reduced NTR1 promoter activity by approximately 70 % . Positive_regulation NUAK2 TNF 18023418 1846375 Identification of a novel substrate for *induced* kinase [NUAK2] . Positive_regulation NUDC STK39 18083840 1837362 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation NUP107 CAPN8 24467364 2927303 In vivo and in vitro inhibition *prevented* this [nucleoporin] degradation . Positive_regulation NUP133 CAPN8 24467364 2927219 In vivo and in vitro inhibition *prevented* this [nucleoporin] degradation . Positive_regulation NUP153 CAPN8 24467364 2927345 In vivo and in vitro inhibition *prevented* this [nucleoporin] degradation . Positive_regulation NUP153 CD14 15834312 1394709 These data indicate that functional TLR4 and are *required* for [NPC] production of cytokines and that at least one of the critical components from hepatocytes is LBP . Positive_regulation NUP153 IFI27 12490316 1033147 To clarify the *roles* of and c-myc in [nasopharyngeal carcinoma (NPC)] , we used immunohistochemical studies to examine the expression of p27 and c-myc proteins in 69 patients with NPC . Positive_regulation NUP153 MUC16 19068094 2182130 The results showed that HSP70 and 5B expression *increased* not only in rat [NPC] but also in atypical hyperplasia nasopharyngeal tissues , a precancer stage of NPC . Positive_regulation NUP153 NES 9371762 466139 A functional is *required* for active export , presumably by interacting directly or indirectly with the [nuclear pore complex] . Positive_regulation NUP155 CAPN8 24467364 2927359 In vivo and in vitro inhibition *prevented* this [nucleoporin] degradation . Positive_regulation NUP155 NES 9371762 466140 A functional is *required* for active export , presumably by interacting directly or indirectly with the [nuclear pore complex] . Positive_regulation NUP160 CAPN8 24467364 2927233 In vivo and in vitro inhibition *prevented* this [nucleoporin] degradation . Positive_regulation NUP188 CAPN8 24467364 2927205 In vivo and in vitro inhibition *prevented* this [nucleoporin] degradation . Positive_regulation NUP188 NES 9371762 466111 A functional is *required* for active export , presumably by interacting directly or indirectly with the [nuclear pore complex] . Positive_regulation NUP205 CAPN8 24467364 2927247 In vivo and in vitro inhibition *prevented* this [nucleoporin] degradation . Positive_regulation NUP205 NES 9371762 466112 A functional is *required* for active export , presumably by interacting directly or indirectly with the [nuclear pore complex] . Positive_regulation NUP210 CAPN8 24467364 2927331 In vivo and in vitro inhibition *prevented* this [nucleoporin] degradation . Positive_regulation NUP210 CD14 15834312 1394707 These data indicate that functional TLR4 and are *required* for [NPC] production of cytokines and that at least one of the critical components from hepatocytes is LBP . Positive_regulation NUP210 IFI27 12490316 1033146 To clarify the *roles* of and c-myc in [nasopharyngeal carcinoma (NPC)] , we used immunohistochemical studies to examine the expression of p27 and c-myc proteins in 69 patients with NPC . Positive_regulation NUP210 MUC16 19068094 2182115 The results showed that HSP70 and 5B expression *increased* not only in rat [NPC] but also in atypical hyperplasia nasopharyngeal tissues , a precancer stage of NPC . Positive_regulation NUP210 NES 9371762 466117 A functional is *required* for active export , presumably by interacting directly or indirectly with the [nuclear pore complex] . Positive_regulation NUP214 CAPN8 24467364 2927373 In vivo and in vitro inhibition *prevented* this [nucleoporin] degradation . Positive_regulation NUP214 CD14 15834312 1394711 These data indicate that functional TLR4 and are *required* for [NPC] production of cytokines and that at least one of the critical components from hepatocytes is LBP . Positive_regulation NUP214 IFI27 12490316 1033148 To clarify the *roles* of and c-myc in [nasopharyngeal carcinoma (NPC)] , we used immunohistochemical studies to examine the expression of p27 and c-myc proteins in 69 patients with NPC . Positive_regulation NUP214 MUC16 19068094 2182145 The results showed that HSP70 and 5B expression *increased* not only in rat [NPC] but also in atypical hyperplasia nasopharyngeal tissues , a precancer stage of NPC . Positive_regulation NUP214 NES 9371762 466141 A functional is *required* for active export , presumably by interacting directly or indirectly with the [nuclear pore complex] . Positive_regulation NUP35 CAPN8 24467364 2927289 In vivo and in vitro inhibition *prevented* this [nucleoporin] degradation . Positive_regulation NUP35 NES 9371762 466116 A functional is *required* for active export , presumably by interacting directly or indirectly with the [nuclear pore complex] . Positive_regulation NUP37 CAPN8 24467364 2927317 In vivo and in vitro inhibition *prevented* this [nucleoporin] degradation . Positive_regulation NUP43 ADRB2 10196213 604410 However , endocytosis does not appear to be required for alpha2-adrenergic , epidermal growth factor , lysophosphatidic acid , or *mediated* [p42/p44] MAP kinase activation in COS-1 cells . Positive_regulation NUP43 CAPN8 24467364 2927261 In vivo and in vitro inhibition *prevented* this [nucleoporin] degradation . Positive_regulation NUP43 CD14 7521366 269323 dependent *activation* of protein kinase C and mitogen activated protein kinases ( [p42] and p44 ) in human monocytes treated with bacterial lipopolysaccharide . Positive_regulation NUP43 CTGF 16408113 1513528 P-PI3-K blockade downregulated the *stimulated* expression of P-PI3-K , P-Akt , and NF-kappaB but not [P-p42/44] MAPK , and partially decreased the release of the above chemokines . Positive_regulation NUP43 CTGF 16408113 1513537 LXA ( 4 ) dose-dependently inhibited the *stimulated* mRNA expression and protein release of the above chemokines , and the expression of [P-p42/44MAPK] , P-PI3-K , P-Akt , and NF-kappaB . Positive_regulation NUP43 EDN2 7509933 241585 *stimulates* mitogen activated protein kinase [p42] activity through the phosphorylation of the kinase in rat mesangial cells . Positive_regulation NUP43 EFNB1 15502157 1347554 Further downstream of the signaling pathway , stimulation *led* to increased LAT ( linker for activation of T-cells ) phosphorylation and [p44/42] and p38 MAPK activation . Positive_regulation NUP43 EPHB2 21518868 2428892 EGF activates NF-?B and stimulates phosphorylation of FER , EGF receptor (EGFR) , and ERK [p42/p44] , and decreased expression of FER or inhibition of phosphorylation *inhibits* the EGF induced activation of NF-?B . Positive_regulation NUP43 F2R 11841573 912181 Activation of the microglial *induces* a rapid cytosolic free [ Ca2+ ] i increase and transient activation of both p38 and [p44/42] mitogen activated protein kinases . Positive_regulation NUP43 F2R 19360302 2058256 We found that stimulation of HCC cells with thrombin , the activating peptide , TFLLRN-NH2 , and the PAR4-selective activating peptide , AYPGKF-NH2 , increased cell invasion across a Matrigel coated membrane barrier and *stimulated* activation of [p42/p44] MAPKinase phosphorylation . Positive_regulation NUP43 F2R 21252088 2402879 In the present study , we show that FVIIa , upon binding to EPCR on endothelial cells , activates endogenous protease activated receptor-1 (PAR1) and induces mediated [p44/42] mitogen activated protein kinase (MAPK) *activation* . Positive_regulation NUP43 FAS 16024776 1435371 In contrast , *mediated* activation of JNK , p38 , and [p42/44] occurred essentially independent from IFN-gamma sensitization , indicating that the apoptosis- and NF-kappaB related FasL-IFN-gamma cross talk was not due to a simple global enhancement of Fas signaling . Positive_regulation NUP43 HBEGF 11171084 783774 Both [p42] MAPK activation and mRNA *induction* were inhibited by genistein , indicating a requirement for an upstream tyrosine kinase activity . Positive_regulation NUP43 IL1B 11455208 837912 TNF-alpha and *activated* [p44/42] and p38 mitogen activated protein kinases ( MAPKs ) in HUVECs ; Positive_regulation NUP43 IL1B 11777983 899907 Furthermore , IL-17 , , and TNF-alpha *induced* a rapid activation of extracellular signal related kinase [p42/44] and p38 MAPKs , and specific MAPK inhibitors ( SB203580 , PD98059 , and U0216 ) significantly reduced IL-17- , IL-1beta- , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Positive_regulation NUP43 IL1B 12356282 993790 induced [p44/42] mitogen activated protein kinase (MAPK) *activation* was inhibited by the MAPK/extracellular signal regulated protein kinase ( MEK ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation NUP43 IL1B 12760902 1119669 and TGF-beta1 *induced* an activation of ERK [p42/44] and p38 MAP kinases , and the MAP kinase inhibitors ( SB-202190 , PD-98059 , and U-0216 ) significantly reduced the IL-1beta- and TGF-beta1 induced IL-11 secretion . Positive_regulation NUP43 IL1B 15067222 1231908 This hypothesis was further supported by the transient activation of [p42/p44] and p38 MAPKs *induced* by . Positive_regulation NUP43 IL1B 16141635 1454862 DHA stimulated both rapid and prolonged activation of [p44/42] , but not p38 , mitogen activated protein kinase (MAPK) *induced* by and PMA . Positive_regulation NUP43 IL1B 16521184 1531271 *activates* [p44/42] and p38 mitogen activated protein kinases via different pathways in cat esophageal smooth muscle cells . Positive_regulation NUP43 IL1B 16521184 1531273 Phosphokinase C ( PKC ) was found to play a mediating role in the *induced* [p44/42] MAP kinase activity . Positive_regulation NUP43 IL1B 16521184 1531275 Based on these results , induced [p44/42] MAP kinase *activation* is mediated by the Gi protein , tyrosine kinase , phospholipase C (PLC) and PKC . Positive_regulation NUP43 LBP 11134043 794921 Here we show that secretion of tumor necrosis factor-alpha induced by Treponema culture supernatants and extracted LTA was paralleled by an *dependent* phosphorylation of mitogen activated protein kinases ( MAPKs ) [p42] and p44 , and p38 , as well as the stress activated protein kinases c-Jun N-terminal kinases 1 and 2 . Positive_regulation NUP43 MAP2K6 11462762 839164 These injury conditions led to a rapid phosphorylation of [p44/42] that was *blocked* by inhibitors . Positive_regulation NUP43 MAP2K6 11479233 842208 Inhibitors of ( U0126 ) and PI3K ( LY294002 ) *blocked* [p42/p44] ( erk ) and Akt , respectively , and partially blocked HGF induced production of IL-8 and VEGF , whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A . Positive_regulation NUP43 MAP2K6 12356282 993796 IL-1beta induced [p44/42] mitogen activated protein kinase (MAPK) activation was *inhibited* by the MAPK/extracellular signal regulated protein kinase ( ) inhibitor , PD 98059 ( 30 microM ) , while byakangelicol ( 50 microM ) had no effect . Positive_regulation NUP43 MAP2K6 9626658 511847 These results indicate that *mediates* the IGF-I/insulin induced [p42/] p44 MAPK activation . Positive_regulation NUP43 NES 9371762 466114 A functional is *required* for active export , presumably by interacting directly or indirectly with the [nuclear pore complex] . Positive_regulation NUP43 PLAU 15031204 1257163 In HeLa cells the dominant negative form of JNK interferes with the [p42/p44] MAPK *activation* of the . Positive_regulation NUP43 S100B 17564756 1804574 By contrast , in FL-RAGE cells but not in Delta-RAGE cells and AGEs *activate* [p42/44] MAPK , augment cyclin D(1)/cdk4 protein and RNA levels and the transition into the S-phase . Positive_regulation NUP43 TNF 10501211 648486 In contrast , did not *activate* the extracellular signal regulated kinase ( MAP kinase ) [p42] , nor did it elicit a mitogenic response . Positive_regulation NUP43 TNF 11043572 742368 These activation kinetics suggest a mechanism of p42/44 action more complicated than a direct phosphorylation of IRS-1 triggered by the early spike of *induced* [p42/44] activity . Positive_regulation NUP43 TNF 11435466 832522 However , the cytotoxic responses to daunorubicin and exogenous ceramide remain unaltered , as do the *induced* [p42/p44] MAPK activation and CD54 expression . Positive_regulation NUP43 TNF 11438547 843388 *activated* p38 MAPK and [p44/p42] MAPK in wild-type but not in p60 ( -/- ) , p80 ( -/- ) , or p60 ( -/- ) p80 ( -/- ) macrophages . Positive_regulation NUP43 TNF 11455208 837911 and IL-1beta *activated* [p44/42] and p38 mitogen activated protein kinases ( MAPKs ) in HUVECs ; Positive_regulation NUP43 TNF 11495721 846380 Furthermore , overexpression of dominant negative mutants , H-Ras-15A and Raf-N4 , significantly suppressed [p42/p44] mitogen activated protein kinase (MAPK) activation *induced* by and PDGF-BB and attenuated the effect of TNF-alpha on BK-induced IP response , indicating that Ras and Raf may be required for activation of these kinases . Positive_regulation NUP43 TNF 11777983 899904 Furthermore , IL-17 , IL-1beta , and *induced* a rapid activation of extracellular signal related kinase [p42/44] and p38 MAPKs , and specific MAPK inhibitors ( SB203580 , PD98059 , and U0216 ) significantly reduced IL-17- , IL-1beta- , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Positive_regulation NUP43 TNF 11930247 927413 The [p44/42] MAPK activity was significantly *enhanced* by and the TNF-alpha effect was opposed by rhIL-10 . Positive_regulation NUP43 TNF 12060576 952774 Strikingly , the *activation* of [p42] ( mapk/erk2 ) and Akt by was also inhibited in the presence of NaCl . Positive_regulation NUP43 TNF 12160518 971795 *activated* [p44/42] and p38 MAP kinases , which was inhibited by the specific inhibitors of these kinases , PD98059 or SB202190 , respectively . Positive_regulation NUP43 TNF 14751545 1205479 This hypothesis was further supported by that *induced* a transient activation of [p42/p44] and p38 MAPKs in a time-and concentration dependent manner . Positive_regulation NUP43 TNF 15240695 1270312 Jurkat cells that did not express Syk ( JCaM1 , JCaM1/lck ) showed lack of *induced* Syk , JNK , p38 MAPK , and [p44/p42] MAPK activation , as well as TNF induced IkappaBalpha phosphorylation , IkappaBalpha degradation , and NF-kappaB activation . Positive_regulation NUP43 TNF 15365619 1334203 Rosiglitazone ameliorates insulin resistance in brown adipocytes of Wistar rats by impairing *induction* of p38 and [p42/p44] mitogen activated protein kinases . Positive_regulation NUP43 TNF 15452110 1341985 In contrast , induced [p42/p44] MAPK *activation* and CD54 expression remained unaltered . Positive_regulation NUP43 TNF 16682409 1584050 Further , the deletion of NQO1 abolished induced c-Jun N-terminal kinase , Akt , p38 , and [p44/p42] mitogen activated protein kinase *activation* . Positive_regulation NUP43 TNF 17161959 1694531 Upon examination of the signaling components , we found that was a potent *activator* of p38 , [p44/42] , p54/46 MAPK , and IkappaBalpha ( IkappaBalpha ) . Positive_regulation NUP43 TNF 17942934 1814207 Deletion of NQO2 also abolished *induced* c-Jun NH2-terminal kinase , Akt , p38 , and [p44/p42] mitogen activated protein kinase activation . Positive_regulation NUP43 TNF 18258304 1884775 *induces* [p42/p44] , p54 and p38 MAPK kinase ; Positive_regulation NUP43 TNF 18258304 1884790 However , over-expression of a dominant negative form of Rac strongly inhibited induced [p42/44] MAPK kinase *activation* , but had little effect upon JNK and no effect upon p38 MAPK activity . Positive_regulation NUP43 TNF 19441104 2101430 D10 supplementation did not suppress activation of hepatocyte growth factor (HGF) , induction of transforming growth factor alpha ( TGF-alpha ) expression , or alpha-interleukin-6 cytokine signaling , [p42/44] extracellular signal regulated kinase ( ERK ) *activation* , immediate early gene expression , or expression of CCAAT/enhancer binding protein beta ( C/EBPbeta ) , but did augment expression of the mito-inhibitory factors C/EBPalpha , p21 ( Waf1/Cip1 ) , and p27 ( Kip1 ) . Positive_regulation NUP43 TNF 20372827 2238935 VIP markedly up-regulated the *induced* [p44/p42] MAP kinase phosphorylation . Positive_regulation NUP43 TNF 21520062 2423115 Here , we report that *induced* cPLA(2) protein and mRNA expression , PGE ( 2 ) production , and phosphorylation of [p42/p44] MAPK , p38 MAPK , and JNK1/2 , which were attenuated by pretreatment with a ROS scavenger [ N-acetyl-L-cysteine , ( NAC ) ] and the inhibitors of NADPH oxidase [ apocynin (APO) and diphenyleneiodonium chloride ( DPI ) ] , MEK1/2 ( U0126 ) , p38 MAPK ( SB202190 ) , and JNK1/2 ( SP600125 ) or transfection with siRNA of Nox2 , p47(phox) , MEK1 , p42 , p38 , or JNK2 . Positive_regulation NUP43 TNF 24441870 2922923 We showed that markedly *stimulated* Jak2 , PDGFR , Akt , and [p42/p44] MAPK phosphorylation , which were attenuated by their respective inhibitors . Positive_regulation NUP43 TNF 24441870 2922945 In addition , *induced* [p42/p44] MAPK phosphorylation was reduced by AG1296 or LY294002 . Positive_regulation NUP43 TNF 24441870 2922978 On the other hand , could *induce* Akt and [p42/p44] MAPK translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation NUP43 TNF 7726846 302074 Since we recently found that stimulation of neutrophils does not *increase* the tyrosine phosphorylation or activation of the [p42erk2] and p44erk1 mitogen activated protein kinases ( MAPKs ) , the present studies demonstrate the involvement of a MAPK independent pathway in the phosphorylation and activation of cPLA2 . Positive_regulation NUP43 TNF 8626494 360270 Inhibition of induced [p42/p44] mitogen activated protein kinase *activation* by sodium salicylate . Positive_regulation NUP43 TNF 8626494 360284 *activates* both [p42] and p44 mitogen activated protein kinases (MAPK) in human FS-4 fibroblasts , cells for which TNF is mitogenic . Positive_regulation NUP43 TNF 8626494 360312 We now show that neither phorbol ester-sensitive protein kinase C nor Gialpha link TNF to p42/p44 MAPK activation , because pretreatment of FS-4 cells with phorbol ester to down-regulate protein kinase C or pretreatment with pertussis toxin to block Gialpha does not inhibit [p42/p44] MAPK *activation* by . Positive_regulation NUP43 TNF 8626494 360328 To further analyze MAPK activation in FS-4 cells , we compared [p42/p44] MAPK *activation* by and epidermal growth factor (EGF) . Positive_regulation NUP43 TNF 8626494 360357 Elucidation of the mechanism whereby sodium salicylate blocks induced [p42/p44] MAPK *activation* may help to clarify TNF activated signaling pathways . Positive_regulation NUP43 TNF 9096313 422378 In a previous study , we demonstrated that sodium salicylate ( NaSal ) selectively inhibits induced *activation* of the [p42] and p44 mitogen activated protein kinases ( MAPKs ) ( known as extracellular signal regulated kinases ) . Positive_regulation NUP43 TNF 9176264 433702 The .NO synthase inhibitor aminoguanidine ( 100 microM ) prevented the *induced* increase in NO2- , nitrotyrosine immunofluorescence , oxidized [p42] , and permeability . Positive_regulation NUP43 TNF 9885438 558291 On the other hand , selectively *induced* tyrosine phosphorylation of [p42] , and PMA selectively induced that of p44 and p42 . Positive_regulation NUP43 TNFSF10 19895579 2176166 Preceding cell death , *activated* nuclear factor kappaB , c-Jun N-terminal kinase , p38 and [p42/44] . Positive_regulation NUP50 CAPN8 24467364 2927387 In vivo and in vitro inhibition *prevented* this [nucleoporin] degradation . Positive_regulation NUP50 NES 9371762 466142 A functional is *required* for active export , presumably by interacting directly or indirectly with the [nuclear pore complex] . Positive_regulation NUP54 CAPN8 24467364 2927191 In vivo and in vitro inhibition *prevented* this [nucleoporin] degradation . Positive_regulation NUP62 CAPN8 24467364 2927401 In vivo and in vitro inhibition *prevented* this [nucleoporin] degradation . Positive_regulation NUP62 CD14 15834312 1394713 These data indicate that functional TLR4 and are *required* for [NPC] production of cytokines and that at least one of the critical components from hepatocytes is LBP . Positive_regulation NUP62 IFI27 12490316 1033149 To clarify the *roles* of and c-myc in [nasopharyngeal carcinoma (NPC)] , we used immunohistochemical studies to examine the expression of p27 and c-myc proteins in 69 patients with NPC . Positive_regulation NUP62 MUC16 19068094 2182160 The results showed that HSP70 and 5B expression *increased* not only in rat [NPC] but also in atypical hyperplasia nasopharyngeal tissues , a precancer stage of NPC . Positive_regulation NUP85 CAPN8 24467364 2927443 In vivo and in vitro inhibition *prevented* this [nucleoporin] degradation . Positive_regulation NUP85 NES 9371762 466145 A functional is *required* for active export , presumably by interacting directly or indirectly with the [nuclear pore complex] . Positive_regulation NUP88 CAPN8 24467364 2927415 In vivo and in vitro inhibition *prevented* this [nucleoporin] degradation . Positive_regulation NUP88 NES 9371762 466143 A functional is *required* for active export , presumably by interacting directly or indirectly with the [nuclear pore complex] . Positive_regulation NUP93 CAPN8 24467364 2927275 In vivo and in vitro inhibition *prevented* this [nucleoporin] degradation . Positive_regulation NUP93 NES 9371762 466115 A functional is *required* for active export , presumably by interacting directly or indirectly with the [nuclear pore complex] . Positive_regulation NUP98 CAPN8 24467364 2927429 In vivo and in vitro inhibition *prevented* this [nucleoporin] degradation . Positive_regulation NUP98 NES 9371762 466144 A functional is *required* for active export , presumably by interacting directly or indirectly with the [nuclear pore complex] . Positive_regulation NUPL2 NES 9371762 466110 A functional is *required* for active export , presumably by interacting directly or indirectly with the [nuclear pore complex] . Positive_regulation OAS1 IFI27 18329281 1891936 However , the up-regulation by healthy pregnancy serum was not due to a general type 1 interferon response , since 6-16 and [OAS1] were not *up-regulated* similarly . Positive_regulation OAS1 IL1B 12051728 950602 *potentiated* IFN-alpha induced 2 ( ` ) 5 ( ` ) [-OAS] and PKR gene expression , similar to expression of the transfected reporter genes containing the IFN stimulated regulatory elements , while IL-10 suppressed IFN-alpha stimulated gene expression . Positive_regulation OAS1 MX2 19577285 2117545 Furthermore , deficient S100A11 gene expression significantly impaired IL-29 ( IFN-lambda1 ) responsiveness ( [2' 5'-oligoadenylate synthetase] and *induction* ) and its anti-VV effects in keratinocytes . Positive_regulation OAS1 TLR7 19643938 2185782 *induced* myxovirus resistance protein A and [2'5' oligoadenylate synthetase] mRNA expression and protein levels of IP-10 were significantly lower in asthma subjects compared with healthy subjects ( p = 0.041 , p = 0.003 and p = 0.001 respectively ) . Positive_regulation OAS1 TNF 1314865 185354 The sixteenfold increase over constitutive intracellular [2'-5' oligo-adenylate synthetase] ( 2'-5 ' A synthetase ) activity *induced* by ( 400 U/ml ) failed to occur when PFN ( 1 mg/ml ) was added prior to cytokine treatment . Positive_regulation OAS1 TNF 2550793 117633 This antiviral state is quite similar to that established by interferon ( IFN ) , e.g. , treatment of HEp-2 cells *induces* [2',5'-oligoadenylate synthetase] activity . Positive_regulation OAS1 TNF 8279819 240517 *Induction* of [2',5'-oligo-adenylate (2-5A) synthetase] by is also enhanced by quercetin . Positive_regulation OAS2 IL1B 12051728 950603 *potentiated* IFN-alpha induced 2 ( ` ) 5 ( ` ) [-OAS] and PKR gene expression , similar to expression of the transfected reporter genes containing the IFN stimulated regulatory elements , while IL-10 suppressed IFN-alpha stimulated gene expression . Positive_regulation OAS2 MX2 19577285 2117547 Furthermore , deficient S100A11 gene expression significantly impaired IL-29 ( IFN-lambda1 ) responsiveness ( [2' 5'-oligoadenylate synthetase] and *induction* ) and its anti-VV effects in keratinocytes . Positive_regulation OAS2 TLR7 19643938 2185783 *induced* myxovirus resistance protein A and [2'5' oligoadenylate synthetase] mRNA expression and protein levels of IP-10 were significantly lower in asthma subjects compared with healthy subjects ( p = 0.041 , p = 0.003 and p = 0.001 respectively ) . Positive_regulation OAS2 TNF 1314865 185355 The sixteenfold increase over constitutive intracellular [2'-5' oligo-adenylate synthetase] ( 2'-5 ' A synthetase ) activity *induced* by ( 400 U/ml ) failed to occur when PFN ( 1 mg/ml ) was added prior to cytokine treatment . Positive_regulation OAS2 TNF 2550793 117634 This antiviral state is quite similar to that established by interferon ( IFN ) , e.g. , treatment of HEp-2 cells *induces* [2',5'-oligoadenylate synthetase] activity . Positive_regulation OAS2 TNF 8279819 240518 *Induction* of [2',5'-oligo-adenylate (2-5A) synthetase] by is also enhanced by quercetin . Positive_regulation OAS3 IL1B 12051728 950604 *potentiated* IFN-alpha induced 2 ( ` ) 5 ( ` ) [-OAS] and PKR gene expression , similar to expression of the transfected reporter genes containing the IFN stimulated regulatory elements , while IL-10 suppressed IFN-alpha stimulated gene expression . Positive_regulation OAS3 MX2 19577285 2117549 Furthermore , deficient S100A11 gene expression significantly impaired IL-29 ( IFN-lambda1 ) responsiveness ( [2' 5'-oligoadenylate synthetase] and *induction* ) and its anti-VV effects in keratinocytes . Positive_regulation OAS3 TLR7 19643938 2185784 *induced* myxovirus resistance protein A and [2'5' oligoadenylate synthetase] mRNA expression and protein levels of IP-10 were significantly lower in asthma subjects compared with healthy subjects ( p = 0.041 , p = 0.003 and p = 0.001 respectively ) . Positive_regulation OAS3 TNF 1314865 185356 The sixteenfold increase over constitutive intracellular [2'-5' oligo-adenylate synthetase] ( 2'-5 ' A synthetase ) activity *induced* by ( 400 U/ml ) failed to occur when PFN ( 1 mg/ml ) was added prior to cytokine treatment . Positive_regulation OAS3 TNF 2550793 117635 This antiviral state is quite similar to that established by interferon ( IFN ) , e.g. , treatment of HEp-2 cells *induces* [2',5'-oligoadenylate synthetase] activity . Positive_regulation OAS3 TNF 8279819 240519 *Induction* of [2',5'-oligo-adenylate (2-5A) synthetase] by is also enhanced by quercetin . Positive_regulation OATP1 ABCG2 19139163 2048002 It is interesting to note that transport of 17beta-estradiol 17beta-d-glucuronide ( control ) , gimatecan , and BNP1350 by [OATP1B1] could be completely *inhibited* by the classic ABCB1 and/or inhibitors elacridar , valspodar , pantoprazole , and , to a lesser extent , zosuquidar and verapamil . Positive_regulation OCLN ANGPT1 15056293 1229947 A pericyte derived multimeric complex *induces* [occludin] gene expression in brain capillary endothelial cells through Tie-2 activation in vitro . Positive_regulation OCLN EPHB2 10898713 712110 H ( 2 ) O ( 2 ) mediates changes in ERK1/ERK2 phosphorylation , increases endothelial solute permeability , and alters [occludin] localization and phosphorylation were all *blocked* by PD-98059 , a specific mitogen activated protein ( MAP ) or kinase 1 inhibitor . Positive_regulation OCLN FLG 22796440 2645586 Reduced expression of epidermal growth factor receptor , E-cadherin , and [occludin] in the skin of flaky tail mice is *due* to and loricrin deficiencies . Positive_regulation OCLN FLG 22796440 2645590 Our findings suggest that the observed reductions in EGFR , E-cadherin , and [occludin] expression were *due* to deficiency accompanied with subsequent loricrin deficiency and disruption of the SIRT1 pathway in the skin of Flg ( ft ) mice . Positive_regulation OCLN IL1B 15350541 1292417 *regulates* expression of Cx32 , [occludin] , and claudin-2 of rat hepatocytes via distinct signal transduction pathways . Positive_regulation OCLN MMP28 14672808 1189122 PAO induced [occludin] proteolysis could be *prevented* by different inhibitors . Positive_regulation OCLN MMP28 19141539 2060902 Indeed , the HIV induced decrease in the expression of JAM-A and [occludin] was *restored* by inhibition of activity . Positive_regulation OCLN MMP28 20197061 2229374 inhibition by the metalloproteinase inhibitor GM6001 *prevented* [occludin] degradation and reduced the intercellular gap formation . Positive_regulation OCLN MMP28 21777561 2467240 We show that extracellular matrix metalloproteinase inducer ( EMMPRIN ; also termed CD147 ) , an inducer of MMP expression , participates in the pathogenesis of dry eye through *mediated* cleavage of [occludin] , an important component of tight junctions . Positive_regulation OCLN MMP7 14672808 1189137 PAO induced [occludin] proteolysis could be *prevented* by different inhibitors . Positive_regulation OCLN MMP7 19141539 2060917 Indeed , the HIV induced decrease in the expression of JAM-A and [occludin] was *restored* by inhibition of activity . Positive_regulation OCLN MMP7 20197061 2229389 inhibition by the metalloproteinase inhibitor GM6001 *prevented* [occludin] degradation and reduced the intercellular gap formation . Positive_regulation OCLN MMP7 21777561 2467255 We show that extracellular matrix metalloproteinase inducer ( EMMPRIN ; also termed CD147 ) , an inducer of MMP expression , participates in the pathogenesis of dry eye through *mediated* cleavage of [occludin] , an important component of tight junctions . Positive_regulation OCLN PLAT 21610723 2470315 Both and age independently *increased* claudin 5 and [occludin] phosphorylation during ischemia . Positive_regulation OCLN PLAT 22244977 2564155 GM6001 significantly reduced tPA elevated brain hemoglobin , MMP-9 , and inhibited the degradation of [occludin] and ZO-1 *induced* by , but not claudin-5 . Positive_regulation ODC1 CLU 7518873 265415 Stratum corneum turnover rates ( SCR ) , , protein , DNA and RNA synthesis , and [ornithine decarboxylase (ODC)] *induction* were determined at monthly intervals over a period of two years . Positive_regulation ODC1 IL1B 10623442 658039 *induces* [ornithine decarboxylase] activity in insulin producing cells . Positive_regulation ODC1 IL1B 10623442 658040 Both basal and *induced* [ODC] activities completely disappear following a 2 h block of protein translation . Positive_regulation ODC1 IL1B 1745018 171991 [ODC] activity with similar kinetics but lower peak levels was also *induced* by incubating MCs with mitogens , such as platelet derived growth factor ( PDGF-AB 20 ng/ml ) , arginine vasopressin ( AVP 10 ( -7 ) M ) , phorbol myristate acetate ( PMA 10 ( -7 ) M ) , interleukin 1 alpha and beta ( IL-1 alpha 10 U/ml , 10 U/ml ) . Positive_regulation ODC1 TGM2 6136284 29796 It follows that changes in [ornithine decarboxylase] activity previously observed under these conditions are not *dependent* on activity . Positive_regulation ODC1 TNF 10199820 605367 and IFN-gamma induction of NO generation *resulted* in suppressed [ODC] activity , an effect prevented by the inducible NOS inhibitor L-N6- ( 1-iminoethyl ) lysine ( L-NIL ) . Positive_regulation ODC1 TNF 1385320 200748 IL-1 alpha , IL-1 beta , and TNF beta *induced* HDC and [ODC] , as does LPS . Positive_regulation ODC1 TNF 1472981 207216 2. The *induction* of [ODC] by LPS , IL-1 or was suppressed by GalN in the liver , and this suppression preceded the hepatic congestion . Positive_regulation ODC1 TNF 1641775 194824 The purpose of this study was to determine whether interleukin-1 (IL-1) or , which are released immediately after injury , *regulates* gut mucosal [ODC] enzyme activity and gene expression . Positive_regulation ODC1 TNF 1641775 194828 IL-1 , but not , *increased* small intestinal [ODC] enzyme activity . Positive_regulation ODC1 TNF 1641775 194830 Both IL-1 and *increased* small intestinal [ODC] mRNA levels . Positive_regulation ODC1 TNF 1874802 165375 *stimulates* [ornithine decarboxylase] activity in human fibroblasts and tumor target cells . Positive_regulation ODC1 TNF 1874802 165376 induced cytotoxicity in ME-180 cervical carcinoma cells and , interestingly , *stimulated* both [ODC] activity ( 3-6-fold ) and putrescine accumulation when measured prior to the onset of cytotoxicity . Positive_regulation ODC1 TNF 1874802 165377 Based upon studies with cycloheximide , de novo protein biosynthesis was required for mediated [ODC] *induction* in ME-180 cells . Positive_regulation ODC1 TNF 1874802 165378 Interferon gamma treatment had no significant effect on basal ODC activity but inhibited mediated [ODC] *induction* by approximately 50 % . Positive_regulation ODC1 TNF 2784963 111442 *Induction* of histidine and [ornithine decarboxylase] activities in mouse tissues by recombinant interleukin-1 and . Positive_regulation ODC1 TNF 8300853 248684 When used individually , however , only IL-1 alpha ( 79 +/- 3 % ) , IFN-gamma ( 70 +/- 2 % ) and ( 65 +/- 5 % ) *induced* [ODC] hsp72 expression in mixed glial cell cultures . Positive_regulation ODC1 TNF 9632528 512705 In PC60 R55/R75 cells , *induced* [ODC] activity was completely suppressed by externally added spermine ( Spm ) . Positive_regulation OLFM4 EGF 21048224 2344476 [Olfactomedin-4] regulation by estrogen in the human endometrium *requires* signaling . Positive_regulation OLFM4 EGF 21048224 2344478 In turn , *activates* the [OLFM-4] promoter , and estrogen receptor-a is needed for the complete EGF response . Positive_regulation OLFM4 ERN1 24043762 2846306 This is characterized by intestinal stem cell ( ISC ) expansion as shown by an *mediated* increase in Lgr5 ( + ) and [Olfm4] ( + ) ISCs and a Stat3 dependent increase in the proliferative output of transit amplifying cells . Positive_regulation OLFM4 NOTCH1 22190634 2537351 Furthermore , expression of the CBC stem cell-specific marker [Olfm4] was directly *dependent* on signaling , with transcription activated through RBP-J? binding sites in the promoter . Positive_regulation OLFM4 NOTCH2 22190634 2537352 Furthermore , expression of the CBC stem cell-specific marker [Olfm4] was directly *dependent* on signaling , with transcription activated through RBP-J? binding sites in the promoter . Positive_regulation OLFM4 NOTCH3 22190634 2537353 Furthermore , expression of the CBC stem cell-specific marker [Olfm4] was directly *dependent* on signaling , with transcription activated through RBP-J? binding sites in the promoter . Positive_regulation OLFM4 NOTCH4 22190634 2537354 Furthermore , expression of the CBC stem cell-specific marker [Olfm4] was directly *dependent* on signaling , with transcription activated through RBP-J? binding sites in the promoter . Positive_regulation OLIG2 EPHB2 22901811 2647436 Here , we show that biallelic Nf1 inactivation promotes *dependent* , ectopic [Olig2] expression specifically in transit amplifying progenitors , leading to increased gliogenesis at the expense of neurogenesis in neonatal and adult subventricular zone ( SVZ ) . Positive_regulation OLR1 CD14 19730000 2152394 The epithelioid-like CK ( + ) cells did not regulate [LOX-1] expression upon oxLDL application , but the expression of TLR4 and *increased* between 0 and 36 h of oxLDL/nDL treatment . Positive_regulation OLR1 HBEGF 15380451 1298428 *induces* expression of [lectin-like oxidized LDL receptor-1] in vascular smooth muscle cells . Positive_regulation OLR1 HBEGF 15380451 1298431 Here we show that heparin binding epidermal growth factor-like growth factor ( ) , a potent mitogen for vascular smooth muscle cells , *induces* [LOX-1] expression in cultured bovine aortic smooth muscle cells . Positive_regulation OLR1 HBEGF 15380451 1298432 *induced* expression of [LOX-1] was suppressed by ZD1839 , an inhibitor of EGF receptor phosphorylation . Positive_regulation OLR1 HBEGF 15380451 1298441 Both MEK and p38 mitogen activated protein kinase (MAPK) inhibitors significantly blocked [LOX-1] upregulation *induced* by . Positive_regulation OLR1 HBEGF 15380451 1298455 Phosphatidylinositol 3-kinase (PI3K) inhibitors also blocked *induced* [LOX-1] expression . Positive_regulation OLR1 HBEGF 18282574 1911700 Inhibitors of metalloproteinases , epidermal growth factor (EGF) receptor tyrosine kinase , heparin binding EGF-like growth factor ( ) , p38 mitogen activated protein kinase ( p38 MAPK ) , MAPK kinase ( MEK1 ) and phosphoinositide 3-kinase (PI3K) significantly *blocked* RLP induced [LOX-1] expression and cell migration of BVSMCs . Positive_regulation OLR1 IL1B 15271788 1302370 The PPARgamma activator , 15d-PGJ ( 2 ) , however , inhibited *induced* upregulation of [LOX-1] . Positive_regulation OLR1 TNF 11511093 848823 PPARgamma ligands inhibit *induced* [LOX-1] expression in cultured endothelial cells . Positive_regulation OLR1 TNF 11511093 848824 Natural PPARgamma ligand 15-deoxy-Delta ( 12,14 ) -prostaglandin J ( 2 ) ( 15d-PGJ ( 2 ) ) and the thiazolidinediones , pioglitazone and troglitazone , decreased *induced* [LOX-1] mRNA expression in BAEC . Positive_regulation OLR1 TNF 11511093 848825 In contrast , PPARalpha ligands , Wy14643 and fenofibric acid , did not alter *induced* [LOX-1] expression . Positive_regulation OLR1 TNF 11511093 848827 Taken together , PPARgamma activators inhibit *induced* [LOX-1] expression in cultured BAEC , which may beneficially influence inflammatory responses in atherosclerosis . Positive_regulation OLR1 TNF 12958047 1174108 [LOX-1] , a novel lectin-like receptor for oxidized LDL ( ox-LDL ) , is expressed in *response* to ox-LDL , angiotensin II (Ang II) , , and other stress stimuli . Positive_regulation OLR1 TNF 17868983 1818205 *Up-regulation* of [LOX-1] expression by promotes trans-endothelial migration of MDA-MB-231 breast cancer cells . Positive_regulation OLR1 TNF 17868983 1818206 We showed that *up-regulation* of endothelial [LOX-1] by promoted the adhesion and trans-endothelial migration of MDA-MB-231 breast cancer cells . Positive_regulation OLR1 TNF 20139626 2213736 Leonurus sibiricus herb extract suppresses oxidative stress and ameliorates hypercholesterolemia in C57BL/6 mice and *induced* expression of adhesion molecules and [lectin-like oxidized LDL receptor-1] in human umbilical vein endothelial cells . Positive_regulation OLR1 TNF 20581092 2309113 Adiponectin reduced *induced* [LOX-1] expression . Positive_regulation OLR1 TNF 21544615 2458642 H2 inhibits *induced* [lectin-like oxidized LDL receptor-1] expression by inhibiting nuclear factor ?B activation in endothelial cells . Positive_regulation OLR1 TNF 21544615 2458643 The *induced* upregulation of [LOX-1] was also attenuated by the NF-?B inhibitor N-acetyl-L-cysteine . Positive_regulation OLR1 TNF 24101392 2852461 Prostacyclin and bradykinin did not modulate LOX-1 basal expression but were able to prevent significantly the *up-regulation* of [LOX-1] expression by , in HUVEC in vitro . Positive_regulation OLR1 TNF 9710125 526621 Nuclear runoff assay revealed that *stimulates* transcription of the [LOX-1] gene . Positive_regulation OMP IL1B 14622404 1169170 [Omp100] induced inflammatory cytokine responses of interleukin (IL)-8 , IL-6 and tumour necrosis factor (TNF)alpha in epithelial cells , and *induced* and TNFalpha production in mouse macrophages . Positive_regulation OMP TNF 14622404 1169169 [Omp100] induced inflammatory cytokine responses of interleukin (IL)-8 , IL-6 and tumour necrosis factor (TNF)alpha in epithelial cells , and *induced* IL-1beta and production in mouse macrophages . Positive_regulation OMP TNF 15383598 1298972 Lipidated ( L ) [-Omp16] and L-Omp19 , but not their unlipidated forms , *induced* the secretion of , IL-6 , IL-10 , and IL-12 in a time- and dose dependent fashion . Positive_regulation OPA1 CCND1 21928377 2539272 meanwhile , the expressions of FLT3 , p65 , , and Bc1-2 decreased significantly , and the expression of nuclear Silencing [mediator] for retinoic acid and thyroid hormone receptors ( SMRT ) *increased* notably . Positive_regulation OPA1 CD14 12435950 1016060 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation OPA1 CST6 12753433 1090297 In addition , [mediator] release stimulated by antigen fractions of about 15 kDa was *due* to filarial . Positive_regulation OPA1 CTGF 23108098 2721394 Thrombin is a multifunctional serine protease and an important fibrotic [mediator] that *induces* expression . Positive_regulation OPA1 EPHB2 12769834 1107594 These results show that MSK1 is an important *activated* [mediator] of mitogen stimulated c-fos induction . Positive_regulation OPA1 F2R 12370392 995987 Unlike what is known for FcepsilonRI mediated adhesion , mediated adhesion to FN did not *increase* [mediator] release . Positive_regulation OPA1 F2R 19205424 2007275 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Positive_regulation OPA1 F2R 9141614 428479 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Positive_regulation OPA1 FAS 9481450 476386 More recently , workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic [mediator] , ceramide and that the activity of doxorubicin can be *blocked* by inhibitors of ( fas ) . Positive_regulation OPA1 IL1B 11132773 760286 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation OPA1 IL1B 20380881 2266997 The aim of this study was to test the hypothesis that cellular attachment to the ECM is a critical [mediator] of *induced* signalling pathways and development of reactive phenotype in astrocytes . Positive_regulation OPA1 LBP 12435950 1016061 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Positive_regulation OPA1 NR2F1 24462372 2913092 These findings indicate that plays an important role in the neurodevelopment of the visual system and that its disruption can *lead* to [optic atrophy] with intellectual disability . Positive_regulation OPA1 TLR7 18403024 1914136 In this study we wanted to know whether ligation of expressed by dendritic cells would *induce* differential proinflammatory [mediator] expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation OPA1 TLR7 18584038 1930835 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Positive_regulation OPA1 TLR7 21247892 2409353 One [mediator] whose generation is *induced* by ligation is prostaglandin E ( 2 ) ( PGE ( 2 ) ) , which is well known to increase intracellular cAMP upon G protein coupled receptor ligation . Positive_regulation OPA1 TNF 11132773 760285 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Positive_regulation OPA1 TNF 17389616 1748469 Since tumour necrosis factor (TNF)-alpha is an early mediator of UVR effects , we also examined influence of CLA on *induced* [mediator] release . Positive_regulation OPA1 TNF 17456789 1761151 An interaction of histone deacetylase 3 (HDAC3) and silencing [mediator] for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by and observed in a chromatin immunoprecipitation assay . Positive_regulation OPA1 TNF 23815148 2849309 Part of this difference is because LTa but not can *activate* Herpes Virus Entry [Mediator] and also heterotrimerise with LTß to activate LTßR , which is consistent with the similar phenotypes of the LTa and LTßR deficient mice . Positive_regulation OPA1 TNF 7530746 291714 Our observations suggest that RANTES represents an important [mediator] of lung M phi recruitment in the setting of endotoxemia , and that the expression of RANTES in vivo is *dependent* upon the endogenous production of . Positive_regulation OPA1 TNF 7947995 277238 The current study tested if the *induced* increase in lipid [mediator] production may be , in part , due to altered CoA-IT activity . Positive_regulation OPA1 TNF 9288135 452530 We hypothesized that IL-1 and production in the lungs is essential to the development of ARDS and is *induced* by a [mediator] released from the inflamed pancreas . Positive_regulation OPA2 NR2F1 24462372 2913093 These findings indicate that plays an important role in the neurodevelopment of the visual system and that its disruption can *lead* to [optic atrophy] with intellectual disability . Positive_regulation OPA3 NR2F1 24462372 2913094 These findings indicate that plays an important role in the neurodevelopment of the visual system and that its disruption can *lead* to [optic atrophy] with intellectual disability . Positive_regulation OPA4 NR2F1 24462372 2913088 These findings indicate that plays an important role in the neurodevelopment of the visual system and that its disruption can *lead* to [optic atrophy] with intellectual disability . Positive_regulation OPA5 NR2F1 24462372 2913089 These findings indicate that plays an important role in the neurodevelopment of the visual system and that its disruption can *lead* to [optic atrophy] with intellectual disability . Positive_regulation OPA6 NR2F1 24462372 2913090 These findings indicate that plays an important role in the neurodevelopment of the visual system and that its disruption can *lead* to [optic atrophy] with intellectual disability . Positive_regulation OPA8 NR2F1 24462372 2913091 These findings indicate that plays an important role in the neurodevelopment of the visual system and that its disruption can *lead* to [optic atrophy] with intellectual disability . Positive_regulation OPN1LW RARB 12242694 990335 Inhibition of RAR function in HMECs by DNRAR suppressed expression of CBP/p300 and expression of in MCF-7 cells *promoted* induction of [CBP/p300] when cells were treated with 1.0 microM all-trans-retinoic acid ( ATRA ) . Positive_regulation OPN1LW TNF 10760264 683518 Here , we show that induction of gene expression in T cells stimulated by engagement of the T cell receptor ( TCR ) or by virus infection *requires* [CBP/p300] . Positive_regulation OPN1LW TNF 12165799 972975 Overexpression of [CBP] *induced* p53 transcriptional activity and recovery of induced inhibition . Positive_regulation OPN1LW TNF 19596989 2112076 The *induction* of [CBP] by was observed only in neurons , but not in astroglia and microglia , and it was contingent on the activation of transcription factor NF-kappaB . Positive_regulation OPN1LW TNF 19596989 2112077 This study illustrates a novel biological *role* of in increasing neuron-specific expression of [CBP] for preconditioning that may have therapeutic potential against neurodegenerative disorders . Positive_regulation OPN1MW FAS 15964831 1434667 However , FN or [CBD] may *induce* without increased activation of Rho ( i.e. the basal level of GTP-Rho induces sufficient phospho-MLC for FA assembly under this condition ) . Positive_regulation OPN1MW IFI27 15297432 1283403 [GCP] *induced* and p53 ( LNCaP only ) protein expression within 6 h and suppressed phosphorylated Akt in both cell lines . Positive_regulation OPN1MW MUC16 21249146 2380048 Shigella [CBD8] and IFN-? *induced* the highest secretion and greatest impairment in tight junctions and , consequently , translocation of gliadin fragments into the lamina propria . Positive_regulation OPRM1 AGR2 8206835 261227 The induction pattern of MOA catabolism shown by strain NT1 harboring the MOP cyclase-deficient pYDPH208 suggests that is converted into MOP by MOP cyclase and that [MOP] , but not AGR , *induces* catabolism of MOA . Positive_regulation OPRM1 GPR115 10698001 671544 To investigate the functional *role* of in homologous desensitization of the [mu-opioid receptor] , human embryonic kidney (HEK) 293 cells , which express a significant level of GRK2 , were stably transfected with the cDNA encoding the rat mu-opioid receptor . Positive_regulation OPRM1 GPR132 10698001 671533 To investigate the functional *role* of in homologous desensitization of the [mu-opioid receptor] , human embryonic kidney (HEK) 293 cells , which express a significant level of GRK2 , were stably transfected with the cDNA encoding the rat mu-opioid receptor . Positive_regulation OPRM1 GPR87 10698001 671613 To investigate the functional *role* of in homologous desensitization of the [mu-opioid receptor] , human embryonic kidney (HEK) 293 cells , which express a significant level of GRK2 , were stably transfected with the cDNA encoding the rat mu-opioid receptor . Positive_regulation OPRM1 TNF 16914208 1646361 Earlier investigations demonstrated up-regulated [mu-opioid receptor] expression in neuronal and immune cells in *response* to IL-1 , IL-4 , IL-6 and . Positive_regulation OPRM1 TNF 19482692 2085909 In this review , the *up-regulation* of human [mu-opioid receptor] gene expression in neuronal and immune effector cells by interleukin-1 , interleukin-4 , interleukin-6 and , as well as its down-regulation by interferon-gamma and granulocyte/macrophage colony stimulating factor will be summarized along with molecular mechanisms , such as transcription factor-promoter-interactions . Positive_regulation OPTC MMP28 22534113 2608257 This study was conducted to investigate the effects of hypoxia and vascular endothelial growth factor ( VEGF ) on *mediated* [opticin] production in retinal pigment epithelium (RPE) cells . Positive_regulation OPTC MMP7 22534113 2608272 This study was conducted to investigate the effects of hypoxia and vascular endothelial growth factor ( VEGF ) on *mediated* [opticin] production in retinal pigment epithelium (RPE) cells . Positive_regulation OPTN TNF 12379221 997093 [OPTN] expression is also *induced* 2.3-fold by and 2.6-fold by prolonged DEX treatment . Positive_regulation OPTN TNF 19340308 2056714 *induced* [optineurin] promoter activity was inhibited by expression of inhibitor of NF-kappaB ( IkappaBalpha ) super-repressor . Positive_regulation OPTN TNF 19340308 2056717 Blocking of NF-kappaB activation resulted in inhibition of *induced* [optineurin] gene expression . Positive_regulation OPTN TNF 9488477 488975 Three major mRNA forms of [FIP-2] have been detected in multiple human tissues , and expression of the transcripts was *induced* by treatment in a time dependent manner in two different cell lines . Positive_regulation OPTN TNF 9488477 488976 These data suggest that [FIP-2] is one of the cellular targets for Ad E3-14.7K and that its mechanism of affecting cell death *involves* the receptor , RIP , or a downstream molecule affected by either of these two molecules . Positive_regulation ORAI1 ANGPT1 23041942 2726885 also *increased* [Orai1] and calmodulin expression in mouse hearts in vivo . Positive_regulation ORAI1 TNF 22241747 2629510 Cav-1 overexpression significantly increased [Orai1] expression and SOCE , especially in the *presence* of . Positive_regulation ORM1 IL1B 8525785 331128 In conclusion , subcutaneous ( probably by stimulation of interleukin-6 ) strongly *induces* fibrinogen and [orosomucoid] expression in rat liver , and suppresses immunohistochemically stainable albumin in a heterogenous way , mainly in the periportal zone . Positive_regulation ORM2 IL1B 8525785 331129 In conclusion , subcutaneous ( probably by stimulation of interleukin-6 ) strongly *induces* fibrinogen and [orosomucoid] expression in rat liver , and suppresses immunohistochemically stainable albumin in a heterogenous way , mainly in the periportal zone . Positive_regulation OSCAR TNF 19756392 2183409 We demonstrate that silibinin can inhibit *induced* osteoclastogenesis as well as the expression of NFATc1 and [OSCAR] . Positive_regulation OSM CHI3L1 21953450 2507276 Activation of STAT3 by [oncostatin M] *induced* expression in astrocytes , whereas expression of a dominant negative STAT3 had a suppressive effect . Positive_regulation OSM IFI27 10951574 723779 Inhibition of MEK activation completely abrogated OSM and IL-6 induced p27kip1 accumulation , while expression of dominant negative STAT5 decreased the [OSM] and IL-6 mediated inhibition of DNA-synthesis and partially *inhibited* accumulation . Positive_regulation OSM IL1B 12097485 961479 PGE ( 2 ) produced in the cocultures is responsible for OSM induction , because pretreatment with indomethacin , an inhibitor of prostaglandin synthesis , as well as depletion of PGE ( 2 ) , abrogate [OSM] expression *induced* by or TNF-alpha . Positive_regulation OSM IL1B 16684952 1560073 [OSM] *induced* HGF secretion to a similar extent as in both a time- and dose dependent manner . Positive_regulation OSM MMP28 11207308 786962 We have previously shown that [OSM] *induces* and tissue inhibitor of metalloproteinase-3 ( TIMP-3 ) gene expression in chondrocytes by protein tyrosine kinase dependent mechanisms . Positive_regulation OSM MMP28 14673992 1178682 Specifically , [OSM] + TNFalpha *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation OSM MMP28 16549372 1582274 TNF-alpha and [OSM] *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation OSM MMP7 11207308 786977 We have previously shown that [OSM] *induces* and tissue inhibitor of metalloproteinase-3 ( TIMP-3 ) gene expression in chondrocytes by protein tyrosine kinase dependent mechanisms . Positive_regulation OSM MMP7 14673992 1178697 Specifically , [OSM] + TNFalpha *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation OSM MMP7 16549372 1582289 TNF-alpha and [OSM] *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation OSM PECAM1 17218396 1717767 These cells expressed CD49f but not CD45 , CD34 , Thy-1 , c-kit , , or flk-1 , and [oncostatin M] *induced* their differentiation . Positive_regulation OSM PLAT 12090757 960035 [Oncostatin M] *induces* and plasminogen activator inhibitor-1 in Calu-1 lung carcinoma cells . Positive_regulation OSM TNF 12097485 961478 PGE ( 2 ) produced in the cocultures is responsible for OSM induction , because pretreatment with indomethacin , an inhibitor of prostaglandin synthesis , as well as depletion of PGE ( 2 ) , abrogate [OSM] expression *induced* by IL-1beta or . Positive_regulation OSR1 BMP1 16243309 1483708 In explant cultures , Bmp activation of Odd skipped related 1 (Odd-1) , the earliest known gene expressed in the intermediate mesoderm , is blocked by cyclohexamide , indicating that the *activation* of [Odd-1] by signaling is translation dependent . Positive_regulation OSR1 BMP10 16243309 1483716 In explant cultures , Bmp activation of Odd skipped related 1 (Odd-1) , the earliest known gene expressed in the intermediate mesoderm , is blocked by cyclohexamide , indicating that the *activation* of [Odd-1] by signaling is translation dependent . Positive_regulation OSR1 BMP15 16243309 1483709 In explant cultures , Bmp activation of Odd skipped related 1 (Odd-1) , the earliest known gene expressed in the intermediate mesoderm , is blocked by cyclohexamide , indicating that the *activation* of [Odd-1] by signaling is translation dependent . Positive_regulation OSR1 BMP2 16243309 1483710 In explant cultures , Bmp activation of Odd skipped related 1 (Odd-1) , the earliest known gene expressed in the intermediate mesoderm , is blocked by cyclohexamide , indicating that the *activation* of [Odd-1] by signaling is translation dependent . Positive_regulation OSR1 BMP3 16243309 1483711 In explant cultures , Bmp activation of Odd skipped related 1 (Odd-1) , the earliest known gene expressed in the intermediate mesoderm , is blocked by cyclohexamide , indicating that the *activation* of [Odd-1] by signaling is translation dependent . Positive_regulation OSR1 BMP4 16243309 1483712 In explant cultures , Bmp activation of Odd skipped related 1 (Odd-1) , the earliest known gene expressed in the intermediate mesoderm , is blocked by cyclohexamide , indicating that the *activation* of [Odd-1] by signaling is translation dependent . Positive_regulation OSR1 BMP5 16243309 1483713 In explant cultures , Bmp activation of Odd skipped related 1 (Odd-1) , the earliest known gene expressed in the intermediate mesoderm , is blocked by cyclohexamide , indicating that the *activation* of [Odd-1] by signaling is translation dependent . Positive_regulation OSR1 BMP6 16243309 1483714 In explant cultures , Bmp activation of Odd skipped related 1 (Odd-1) , the earliest known gene expressed in the intermediate mesoderm , is blocked by cyclohexamide , indicating that the *activation* of [Odd-1] by signaling is translation dependent . Positive_regulation OSR1 BMP7 16243309 1483715 In explant cultures , Bmp activation of Odd skipped related 1 (Odd-1) , the earliest known gene expressed in the intermediate mesoderm , is blocked by cyclohexamide , indicating that the *activation* of [Odd-1] by signaling is translation dependent . Positive_regulation OSR1 CAP1 19395663 2089446 , a transcription factor of the basic region leucine zipper family , *regulates* the [oxidative stress response (OSR)] in Candida albicans . Positive_regulation OSR1 FGF1 23517227 2787875 Moreover , knockdown of Wnk4 significantly reduced the phosphorylation level of [Osr1] *induced* by . Positive_regulation OSR1 FGF10 23517227 2787876 Moreover , knockdown of Wnk4 significantly reduced the phosphorylation level of [Osr1] *induced* by . Positive_regulation OSR1 FGF11 23517227 2787877 Moreover , knockdown of Wnk4 significantly reduced the phosphorylation level of [Osr1] *induced* by . Positive_regulation OSR1 FGF12 23517227 2787878 Moreover , knockdown of Wnk4 significantly reduced the phosphorylation level of [Osr1] *induced* by . Positive_regulation OSR1 FGF13 23517227 2787879 Moreover , knockdown of Wnk4 significantly reduced the phosphorylation level of [Osr1] *induced* by . Positive_regulation OSR1 FGF14 23517227 2787880 Moreover , knockdown of Wnk4 significantly reduced the phosphorylation level of [Osr1] *induced* by . Positive_regulation OSR1 FGF16 23517227 2787881 Moreover , knockdown of Wnk4 significantly reduced the phosphorylation level of [Osr1] *induced* by . Positive_regulation OSR1 FGF17 23517227 2787882 Moreover , knockdown of Wnk4 significantly reduced the phosphorylation level of [Osr1] *induced* by . Positive_regulation OSR1 FGF18 23517227 2787883 Moreover , knockdown of Wnk4 significantly reduced the phosphorylation level of [Osr1] *induced* by . Positive_regulation OSR1 FGF19 23517227 2787884 Moreover , knockdown of Wnk4 significantly reduced the phosphorylation level of [Osr1] *induced* by . Positive_regulation OSR1 FGF2 23517227 2787885 Moreover , knockdown of Wnk4 significantly reduced the phosphorylation level of [Osr1] *induced* by . Positive_regulation OSR1 FGF20 23517227 2787886 Moreover , knockdown of Wnk4 significantly reduced the phosphorylation level of [Osr1] *induced* by . Positive_regulation OSR1 FGF21 23517227 2787887 Moreover , knockdown of Wnk4 significantly reduced the phosphorylation level of [Osr1] *induced* by . Positive_regulation OSR1 FGF22 23517227 2787888 Moreover , knockdown of Wnk4 significantly reduced the phosphorylation level of [Osr1] *induced* by . Positive_regulation OSR1 FGF23 23517227 2787889 Moreover , knockdown of Wnk4 significantly reduced the phosphorylation level of [Osr1] *induced* by . Positive_regulation OSR1 FGF3 23517227 2787890 Moreover , knockdown of Wnk4 significantly reduced the phosphorylation level of [Osr1] *induced* by . Positive_regulation OSR1 FGF4 23517227 2787891 Moreover , knockdown of Wnk4 significantly reduced the phosphorylation level of [Osr1] *induced* by . Positive_regulation OSR1 FGF5 23517227 2787892 Moreover , knockdown of Wnk4 significantly reduced the phosphorylation level of [Osr1] *induced* by . Positive_regulation OSR1 FGF6 23517227 2787893 Moreover , knockdown of Wnk4 significantly reduced the phosphorylation level of [Osr1] *induced* by . Positive_regulation OSR1 FGF7 23517227 2787894 Moreover , knockdown of Wnk4 significantly reduced the phosphorylation level of [Osr1] *induced* by . Positive_regulation OSR1 FGF8 23517227 2787895 Moreover , knockdown of Wnk4 significantly reduced the phosphorylation level of [Osr1] *induced* by . Positive_regulation OSR1 FGF9 23517227 2787896 Moreover , knockdown of Wnk4 significantly reduced the phosphorylation level of [Osr1] *induced* by . Positive_regulation OSR1 GADD45G 22791815 2682134 Together , these results suggest that *induction* of BDA and [ODD] at dA and dG residues is through Cr ( V ) intermediate . Positive_regulation OSR1 GADD45G 22791815 2682135 We propose that these *induced* BDA and [ODD] contribute to mutagenesis of the p53 gene that leads to lung carcinogenesis . Positive_regulation OSR1 IKZF1 18804520 1981228 These findings indicate that [Osr1] expression is *regulated* by Runx2 and , which are known as master-gene of osteogenesis and hematopoiesis , respectively . Positive_regulation OSR1 INS 21909387 2479027 Moreover , insulin administration to WNK4 hypomorphic mice did not increase phosphorylation of OSR1 , SPAK and NCC in the kidney , suggesting that WNK4 is also involved in the *induced* [OSR1] , SPAK and NCC phosphorylation mechanism in vivo . Positive_regulation OSR1 LHX8 23383144 2739521 Ectopic expression of WNK1 , WNK4 or [Osr1] in mammalian cells *induced* the expression of the . Positive_regulation OSR1 MT-CO2 7485922 326881 We tested three devices used for differentiating oesophageal from endotracheal intubation : 1. *dependent* [Oesophageal Detector Device (ODD)] as described by Pollard and Wee , 2 . Positive_regulation OSR1 PI3 24191005 2868458 We found that inhibition of *reduced* [OSR1] activation by osmotic stress . Positive_regulation OSR1 RUNX2 18804520 1981224 [Odd skipped related 1] gene expression is *regulated* by and Ikzf1 transcription factors . Positive_regulation OSR1 RUNX2 18804520 1981227 These findings indicate that [Osr1] expression is *regulated* by and Ikzf1 , which are known as master-gene of osteogenesis and hematopoiesis , respectively . Positive_regulation OSR1 VHL 16176182 1500592 Hypoxic stabilization of [ODD-GFP] in the ectoderm was *restored* by inducing expression in these cells . Positive_regulation OSR1 WNK1 16832045 1587592 Here we present evidence that the protein kinase *regulates* [OSR1] , SPAK , and NKCC activities . Positive_regulation OSR1 WNK1 16832045 1587595 [OSR1] exists in a complex with WNK1 in cells , is *activated* by recombinant in vitro , and is phosphorylated in a WNK1 dependent manner in cells . Positive_regulation OSR1 WNK1 16832045 1587596 Depletion of from HeLa cells by using small interfering RNA *reduces* [OSR1] kinase activity . Positive_regulation OSR1 WNK1 22032326 2527379 In the present study , we first describe the generation of double-knockin ES ( embryonic stem ) cells , where SPAK and [OSR1] can not be *activated* by . Positive_regulation OSR1 WNK1 22989884 2694114 C-terminal fragments of WNK1 that contain three RFXV interaction motifs can bind OSR1 , block activation of OSR1 by sorbitol , and prevent the OSR1 induced enhancement of ion co-transporter activity in cells , further supporting the conclusion that association with is *required* for [OSR1] activation and function at least in some contexts . Positive_regulation OSR2 MSX1 21420399 2416711 These data indicate that [Osr2] *acts* downstream of Pax9 and patterns the mesenchymal odontogenic field through protein-protein interactions with and Pax9 during early tooth development . Positive_regulation OSTC TNF 10753825 681801 Tumor necrosis factor-alpha (TNF-alpha) activated DC1 induced allogeneic naive T cells to produce IFN-gamma , which is typical of Th1 responses , whereas *activated* [DC2] induced allogeneic naive T cells to produce IL-4 and IL-10 , which are typical of Th2 responses . Positive_regulation OTOP1 TNF 24379350 2921675 [Otop1] expression is markedly increased in obese mouse WAT and is *stimulated* by in cultured adipocytes . Positive_regulation OTUD5 IL1R2 21115691 2357904 signaling *regulates* [DUBA] expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production . Positive_regulation OTX1 EPHB2 24098142 2852199 However , even weakly activated *activates* [Otx] and Nodal transcription occasionally , probably because of the inherently stochastic nature of signal transduction processes and binding of transcription factors to target sequences . Positive_regulation OTX2 EPHB2 24098142 2852200 However , even weakly activated *activates* [Otx] and Nodal transcription occasionally , probably because of the inherently stochastic nature of signal transduction processes and binding of transcription factors to target sequences . Positive_regulation OXTR ADRB2 10333543 615139 The objective of the present study was to further elucidate our previous observation that activation *induces* [oxytocin receptor (OTR)] expression in rat myometrium . Positive_regulation OXTR CEBPB 16569740 1568501 In transient transfection studies , [OTR] promoter activity was *increased* by and NF-kappaB , but not by AP-1 . Positive_regulation OXTR EDN1 15860558 1425732 Hence , we propose that an *induced* [OT/OTR] system activation underlies the estrogen dependent hyperresponsiveness to ET-1 . Positive_regulation OXTR EGFR 12810550 1102581 Extracellular signal regulated kinase 1/2 activation by myometrial [oxytocin receptor] *involves* Galpha ( q ) Gbetagamma and tyrosine kinase activation . Positive_regulation OXTR ESR1 11694763 877147 The use of a DNA binding mutant , the TR P box mutant , showed that inhibition of *mediated* induction of the rat [OTR] gene promoter by the TRalpha1 isoform does not require DNA binding ability . Positive_regulation OXTR ESR1 9579693 503400 Using mice genetically deficient in estrogen receptor alpha (ERalpha) , we demonstrate that is not necessary for basal OTR synthesis , but is absolutely *necessary* for the induction of [OTR] binding in the brain by estrogen . Positive_regulation OXTR FOS 10218980 608725 We showed the *requirement* for GABP alpha/beta and in endogenous [OTR] gene expression , using oligonucleotide GABP and AP-1 binding decoys to inhibit serum induced increases in 125I labeled OT antagonist binding to Hs578T cells . Positive_regulation OXTR IL13 20670427 2305316 PCR analysis demonstrates that [OXTR] is expressed in HASMCs under basal conditions and that both and tumor necrosis factor ( TNFalpha ) *stimulate* a time dependent increase in OXTR expression at 6 and 18 hr. Additionally , oxytocin increases cytosolic calcium levels in fura-2 loaded HASMCs that were enhanced in cells treated for 24 hr with IL-13 . Positive_regulation OXTR IL1B 16569740 1568499 induces an *increase* in OTR mRNA concentrations and [OTR] ligand binding in myometrial cells , which is maximal at 4 h and decreased after 20 h . IL-1beta activates the transcription factors AP-1 C/EBPbeta , and NF-kappaB . Positive_regulation OXTR IL1B 20926803 2389278 We show that incubation of primary human amnion epithelial cells with *results* in a rapid , transient up-regulation of [OXTR] mRNA expression , which peaks in prelabor samples after 6 h. Incubation of prelabor amnion epithelial cells with OXT results in a marked increase of prostaglandin E ( 2 ) synthesis , and we demonstrate that OXT activates the extracellular signal regulated protein kinase signal transduction pathway to stimulate up-regulation of cyclo-oxygenase 2 in human amnion epithelial cells . Positive_regulation OXTR IL2 11241181 791969 In contrast , when endometrium was collected in early luteolysis , none of the interleukins altered [OTR] expression or caused a significant stimulation of PGF ( 2alpha ) production but *increased* PGE ( 2 ) . Positive_regulation OXTR JUN 10218980 608726 We showed the *requirement* for GABP alpha/beta and in endogenous [OTR] gene expression , using oligonucleotide GABP and AP-1 binding decoys to inhibit serum induced increases in 125I labeled OT antagonist binding to Hs578T cells . Positive_regulation OXTR JUN 15494465 1359495 Overexpression of C/EBP , but not , *increased* [OTR] promoter activity . Positive_regulation OXTR JUN 16569740 1568502 In transient transfection studies , [OTR] promoter activity was *increased* by C/EBPbeta and NF-kappaB , but not by . Positive_regulation OXTR NFKB1 16569740 1568503 In transient transfection studies , [OTR] promoter activity was *increased* by C/EBPbeta and , but not by AP-1 . Positive_regulation OXTR PGF 15776109 1397358 ( 2alpha ) at 8 % WT levels was *sufficient* to induce coordinated temporal [oxytocin receptor (OTR)] expression in uterus and normal ovarian luteolysis in PGHS1 ( Neo/Neo ) mice at late gestation , while absence of PGHS1 expression in null mice delayed OTR induction and the programmed decrease of serum progesterone during parturition . Positive_regulation OXTR PGF 23678036 2805693 *increased* [OTR] in the lower segment while decreasing it in the upper segment . Positive_regulation OXTR PGF 23678036 2805695 Indomethacin reversed the PGF2a induced effects on CX-43 and PTGS-2 , but it did not alter *induced* PTGFR and [OTR] expression . Positive_regulation OXTR PPP5C 24334513 2921480 E2 and *increased* [OTR] mRNA levels and decreased ERa and ERß mRNA levels 3 and 6 h posttreatment . Positive_regulation OXTR PTGS1 15776109 1397359 PGF ( 2alpha ) at 8 % WT levels was sufficient to induce coordinated temporal oxytocin receptor (OTR) expression in uterus and normal ovarian luteolysis in PGHS1 ( Neo/Neo ) mice at late gestation , while absence of expression in null mice *delayed* [OTR] induction and the programmed decrease of serum progesterone during parturition . Positive_regulation OXTR RELA 16569740 1568504 In transient transfection studies , [OTR] promoter activity was *increased* by C/EBPbeta and , but not by AP-1 . Positive_regulation OXTR RELN 15949229 1421224 Availability of the reelin haploinsufficient ( +/- ) reeler mouse ( HRM ) provides a model for examining the *role* of in the development of the OT system and especially in the expression of the [OT receptor (OTR)] . Positive_regulation OXTR TNF 20670427 2305315 PCR analysis demonstrates that [OXTR] is expressed in HASMCs under basal conditions and that both interleukin (IL)-13 and ( TNFalpha ) *stimulate* a time dependent increase in OXTR expression at 6 and 18 hr. Additionally , oxytocin increases cytosolic calcium levels in fura-2 loaded HASMCs that were enhanced in cells treated for 24 hr with IL-13 . Positive_regulation OXTR VEGFA 12618159 1065779 2. To verify an up-regulation of [oxytocin receptor] expression in MMECs as a *result* of ( VEGF ) , which had been found in a previous study . Positive_regulation P2RX3 VSNL1 23707265 2827903 *Upregulation* of [P2X3] receptors by neuronal calcium sensor protein in dorsal root ganglions contributes to the bone cancer pain in rats . Positive_regulation P2RX3 VSNL1 23707265 2827904 Taken together , these results suggest that functional *upregulation* of [P2X3] receptors by in DRG neurons contributes to the development of cancer induced bone pain in MRMT-1 rats . Positive_regulation P2RX7 IL1B 11860279 917069 Thus , is not *required* for [P2X7] receptor stimulated microglial death . Positive_regulation P2RX7 IL1B 12796490 1120090 Maturation and release of by lipopolysaccharide primed mouse Schwann cells *require* the stimulation of [P2X7] receptors . Positive_regulation P2RX7 IL1B 16301672 1485267 Inhibitory effects of chloride on the *activation* of caspase-1 , secretion , and cytolysis by the [P2X7] receptor . Positive_regulation P2RX7 IL1B 16837047 1666091 In contrast , neither seabream nor zebrafish [P2X(7)] receptors *induced* the secretion of mammalian or fish when expressed in HEK293 , while a chimeric receptor harboring the ATP binding domain of seabream P2X(7) and the intracellular region of its rat counterpart did so . Positive_regulation P2RX7 IL1B 16837047 1666094 These findings indicate that [P2X(7)] receptor mediated activation of ICE and release of *result* from different downstream signaling pathways and suggest that although the mechanisms involved in IL-1beta secretion are conserved throughout evolution , distinct inflammatory signals have been selected for the secretion of this cytokine in different vertebrates . Positive_regulation P2RX7 IL1B 20185692 2272451 and 3 ) to test whether [P2X(7)R] stimulation in T84 monolayers can *induce* caspase-1 activation and release by IEC . Positive_regulation P2RX7 TNF 15830104 1394414 Furthermore , LPS and M-CSF could up-regulate P2X7 receptor expression in monocytes , while IFN-gamma , and GM-CSF had weak effects , but pretreatment with these inducers could not further *enhance* LPS stimulated [P2X7] receptor expression in monocytes . Positive_regulation P2RY12 F2R 15968399 1423778 The [P2Y(12)] receptors also *mediated* the potentiating effect of stimulation on thrombin generation . Positive_regulation P2RY12 F2R 21730013 2476251 Using saturation [ ( 3 ) H ] 2- ( methylthio ) ADP ( [ ( 3 ) H ] 2MeSADP ) binding studies , we first demonstrated that platelet stimulation with thrombin and convulxin ( mouse ) and activating peptide ( TRAP ) ( human ) significantly *increased* surface expression of [P2Y(12)] relative to that of resting platelets . Positive_regulation P2RY2 IL1B 10978250 730964 The cyclooxygenase inhibitor indomethacin and the protein kinase C inhibitor RO-31-8220 inhibited *induced* upregulation of [P2Y(2)] receptor mRNA expression , whereas rapamycin and PD098059 had no effects . Positive_regulation P2RY2 IL1B 20387013 2262071 In rat primary cortical neurons ( rPCNs ) [P2Y(2)R] expression is *increased* by stimulation with , a pro-inflammatory cytokine whose levels are elevated in AD , in part due to nucleotide stimulated release from glial cells . Positive_regulation P2RY2 IL1B 20387013 2262078 Data with rPCNs suggest that [P2Y(2)R] *upregulation* by and subsequent activation by UTP are neuroprotective , since this increases the non-amyloidogenic cleavage of amyloid precursor protein . Positive_regulation P4HB TNF 8691130 372700 However , enhanced in vitro baboon thymocyte proliferation to concanavalin A , and infusion of p75TNF *resulted* in increased soluble [p55] and p75 receptor plasma concentrations . Positive_regulation PABPC1 TNF 12040173 949659 A common feature of each pathway is the *induced* formation of a [multiprotein] signaling complex at the cell membrane . Positive_regulation PADI1 TNF 17079667 1642945 Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination : a role for *induced* [peptidylarginine deiminase] 4 translocation . Positive_regulation PADI2 TNF 17079667 1642944 Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination : a role for *induced* [peptidylarginine deiminase] 4 translocation . Positive_regulation PADI3 CA2 16892136 1597123 Human fibrinogen was deiminated by the [peptidylarginine deiminase (PAD)] in the *presence* of in vitro . Positive_regulation PADI3 CA2 3711070 60261 [Peptidylarginine deiminase] *required* millimolar for the binding to STI-Sepharose . Positive_regulation PADI3 INS 1734040 181662 also *increased* the [peptidylarginine deiminase] activity in a dose dependent manner . Positive_regulation PADI3 NFYA 16671893 1583540 and Sp1/Sp3 are *involved* in the transcriptional regulation of the [peptidylarginine deiminase type III] gene ( PADI3 ) in human keratinocytes . Positive_regulation PADI3 NFYB 16671893 1583541 and Sp1/Sp3 are *involved* in the transcriptional regulation of the [peptidylarginine deiminase type III] gene ( PADI3 ) in human keratinocytes . Positive_regulation PADI3 NFYC 16671893 1583542 and Sp1/Sp3 are *involved* in the transcriptional regulation of the [peptidylarginine deiminase type III] gene ( PADI3 ) in human keratinocytes . Positive_regulation PADI3 SP1 16671893 1583538 NF-Y and are *involved* in the transcriptional regulation of the [peptidylarginine deiminase type III] gene ( PADI3 ) in human keratinocytes . Positive_regulation PADI3 SP3 16671893 1583539 NF-Y and are *involved* in the transcriptional regulation of the [peptidylarginine deiminase type III] gene ( PADI3 ) in human keratinocytes . Positive_regulation PADI3 TNF 17079667 1642943 Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination : a role for *induced* [peptidylarginine deiminase] 4 translocation . Positive_regulation PADI4 TNF 17079667 1642946 Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination : a role for *induced* [peptidylarginine deiminase] 4 translocation . Positive_regulation PADI6 TNF 17079667 1642947 Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination : a role for *induced* [peptidylarginine deiminase] 4 translocation . Positive_regulation PAEP FOLR1 22292640 2520659 In control release tests , DOX behavior of controlled release in *mediated* micellar [folate-PEG-PDLLA-DOX-micelles] was obvious , with pH sensitivity . Positive_regulation PAF1 ALOX5 1650153 162975 Taken together , our studies indicate that [PAF] can significantly augment lung NK cell activity and that this effect is *dependent* on PKC , <5-lipoxygenase> , and extracellular calcium . Positive_regulation PAF1 ALOX5 3152458 104196 This suggests that <5-lipoxygenase> *dependent* mediators and [PAF] are involved in allergic contact dermatitis and that these mediators play only a minor role in irritant dermatitis . Positive_regulation PAF1 ALOX5 6089913 41332 The specific <5-lipoxygenase> inhibitor , 6,8-de-epoxy-6,9- ( phenylimino ) delta 6,8-prostaglandin I1 ( U-60257 ) , *inhibits* [PAF-acether] , but not leukotriene B4-mediated chemotaxis . Positive_regulation PAF1 ALOX5 8415804 234043 Although the early pulmonary vascular response ( < 10 min ) to PAF is dependent on cyclooxygenase products , the sustained response ( after 10 min ) can not be explained by either <5-lipoxygenase> or cyclooxygenase products but may be *mediated* directly by [PAF] receptors . Positive_regulation PAF1 ANGPT1 16617006 1624488 *mediated* endothelial [PAF] synthesis requires the activation of the p38 and p42/44 MAPKs , PI3K intracellular signalling pathways , and a secreted phospholipase A(2) ( sPLA ( 2 ) -V ) . Positive_regulation PAF1 CHI3L1 8245706 236928 On the other hand , the release of [platelet activating factor (PAF)] induced by opsonized particles was *enhanced* only by and not by CGP41-251 and CGP44-800 . Positive_regulation PAF1 EDN2 2051719 161791 In addition , *induced* a significant increase in the production of [PAF] by isolated glomeruli ( Basal , 81 +/- 10 pg/mg protein ; endothelin , 10 ( -7 ) M , 140 +/- 18 pg/mg protein ) . Positive_regulation PAF1 EDN2 8898708 393084 *stimulates* phosphoinositide hydrolysis and [PAF] synthesis in brain microvessels . Positive_regulation PAF1 HBEGF 17322418 1747798 Increased alkaline phosphatase ( AP ) activity after PAF treatment in AP-HB-EGF fusion construct transfected SMCs indicated that [PAF] *induced* the release of within 1 min. Gelatin zymography data showed that PAF stimulated MMP-2 activity and MMP-9 activity within 1 min . Positive_regulation PAF1 IL1B 10447739 577416 We conclude that CRH and [PAF] can *induce* the expression of , but this is not obligatory for increased PGE2 release , and the effect of these stimuli on COX-2 expression is a direct , IL-1beta independent effect . Positive_regulation PAF1 IL1B 1519663 196912 Stimulation of isolated mouse alveolar macrophages with recombinant murine or IL-1 alpha *resulted* in rapid , dose dependent , and cell concentration dependent increases in [PAF] secretion . Positive_regulation PAF1 IL1B 16807360 1612753 In circular muscle , exogenous [PAF] *induced* sequential formation of IL-6 , H ( 2 ) O ( 2 ) , , and PAF . Positive_regulation PAF1 IL1B 16829183 1591454 Both TNF-alpha and induced HUVEC platelet activating factor (PAF) production and [PAF] was *required* for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine ) . Positive_regulation PAF1 IL1B 7882558 298862 and IL-6 *stimulate* the production of [platelet activating factor (PAF)] by cultured rabbit synovial cells . Positive_regulation PAF1 IL1B 8080039 270822 and tumor necrosis factor-alpha *induce* [PAF] production by endothelium , and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist . Positive_regulation PAF1 ITGB2 7902855 245060 Ligation of was not *sufficient* for [PAF] synthesis suggesting that an additional receptor was involved . Positive_regulation PAF1 LBP 7541418 310467 Moreover , LeuM3 , 28C5 , and 18E12 mAbs that were themselves unable to stimulate the synthesis of PAF blocked [PAF] synthesis *initiated* by complex . Positive_regulation PAF1 LBP 7541418 310472 was *required* for synthesis of [PAF] by MO . Positive_regulation PAF1 MAP2K6 10606930 655852 The results showed that TNF alpha , IL-1 alpha and [PAF] *induced* serine phosphorylation of MKK3 and , and p38 MAP kinase activation in BECs . Positive_regulation PAF1 MUC16 9620929 510790 In rat tracheas studied by in situ hybridization , [PAF] *induced* MUC5 gene expression in epithelial cells that stained for mucosubstances . Positive_regulation PAF1 PLAT 1521562 196954 Using a perfused rat hindleg system , release of from endothelial cells could be *induced* by [platelet activating factor (PAF)] , bradykinin , substance P , thrombin , carbachol and A23187 , while this release was inhibited by mepacrine and by nor-dihydroguaiaretic acid . Positive_regulation PAF1 TGM2 7679111 211203 The finding that competitive inhibitors of significantly *inhibited* [C-PAF] release , enhancement of MC540 staining , and externalization of phosphatidylserine , strongly suggest a role for this enzyme in the enhancement of phospholipid transbilayer movement . Positive_regulation PAF1 TNF 10409262 630006 Both and interleukin-1 modestly *increased* plasma [PAF-AH] activity and mRNA levels in liver and spleen , suggesting that they may partly mediate the effect of LPS on PAF-AH . Positive_regulation PAF1 TNF 10435033 634216 ( 4 ) the synthesis of [PAF] *induced* by . Positive_regulation PAF1 TNF 11080081 749568 *increased* the production of [PAF] and NO . Positive_regulation PAF1 TNF 12428690 1014872 Synthesis of [PAF] was not *inducible* by in murine F10-M3 melanoma cells . Positive_regulation PAF1 TNF 15702351 1382769 Finally , up to 2 mug/ml , [PAF] did not *induce* the production of pro-inflammatory cytokines such as IL-6 , IL-8 , and . Positive_regulation PAF1 TNF 1668105 176689 [PAF] *induced* maximal synthesis 2-3 hr after monocyte stimulation as assessed by dot blotting of cell associated TNF alpha using polyclonal anti-TNF antibody . Positive_regulation PAF1 TNF 16829183 1591453 Both and IL-1beta induced HUVEC platelet activating factor (PAF) production and [PAF] was *required* for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine ) . Positive_regulation PAF1 TNF 18180165 1863038 *induces* [platelet activating factor (PAF)] synthesis in many inflammatory cells . Positive_regulation PAF1 TNF 18180165 1863043 We found that , although both cultures synthesized PAF at a similar basal rate , *induced* [PAF] synthesis in adipocytes was 7-fold higher than in preadipocytes . Positive_regulation PAF1 TNF 18180165 1863048 Wortmannin enhanced *dependent* [PAF] synthesis in adipocytes but not in preadipocytes , indicating the negative control by PI3K in mature cells . Positive_regulation PAF1 TNF 20016469 2204614 , which is assumed to mediate the interaction between mesangial cells and podocytes , also *induces* the expression of [platelet activating factor (PAF)] . Positive_regulation PAF1 TNF 20423922 2437238 In rats , increased hydraulic conductivity 2.5-fold over baseline and [PAF] *increased* it 5-fold ; Positive_regulation PAF1 TNF 2137857 128813 The peptide HDMNKVLDL ( antiflammin-2 ) inhibits the synthesis of [platelet activating factor (PAF)] *induced* by or phagocytosis in rat macrophages and human neutrophils , and by thrombin in vascular endothelial cells . Positive_regulation PAF1 TNF 2266661 147301 Inhibitors of PAF synthesis , such as plasma alpha 1-proteinase inhibitor and an anti-inflammatory peptide , blocked changes induced by TNF , PAF receptor antagonists inhibited changes *induced* by [PAF] and also by . Positive_regulation PAF1 TNF 2801951 119978 Since *stimulates* [PAF] synthesis in vitro , we tested the hypothesis that PAF mediates TNF induced lung injury in vivo using specific PAF receptor antagonists . Positive_regulation PAF1 TNF 3049910 99309 and IL-1 *stimulate* the synthesis and release of [platelet activating factor (PAF)] by neutrophils and vascular endothelial cells . Positive_regulation PAF1 TNF 3049910 99317 Low concentrations of this antiproteinase and of human plasma alpha 1-antichymotrypsin inhibited *induced* [PAF] synthesis in neutrophils , macrophages , and vascular endothelial cells . Positive_regulation PAF1 TNF 3119758 80237 Synthesis of [PAF] in *response* to was also detected in rat polymorphonuclear neutrophils , but not in human tumor cells and dermal fibroblasts . Positive_regulation PAF1 TNF 3261295 95990 About 30 % of [PAF] produced in *response* to either or IL-1 is released into the medium , whereas approximately 70 % remains cell associated . Positive_regulation PAF1 TNF 3261295 96008 Experiments with labeled precursors show that [PAF] is synthesized de novo in *response* to . Positive_regulation PAF1 TNF 3261295 96018 This suggests that [PAF] is synthesized by the same pathway in *response* to or IL-1 . Positive_regulation PAF1 TNF 3366898 93070 In the present study , we have shown that ( a ) *caused* [PAF] production in bowel tissue ; Positive_regulation PAF1 TNF 7516414 257607 These results suggest that the angiogenic effect of is , at least in part , *mediated* by [PAF] synthesized from monocytes and/or endothelial cells infiltrating the Matrigel plug . Positive_regulation PAF1 TNF 7681399 214259 In conclusion , the *enhancement* of [PAF] responses by , associated with functional characteristics of differentiation in Mono Mac 6 cells , may represent a specific mechanism of cooperative interaction between PAF and TNF in inflammation , sepsis , immunoregulation and atherogenesis . Positive_regulation PAF1 TNF 7821968 285554 We have shown previously that endotoxin , tumour necrosis factor (TNF) and platelet activating factor (PAF) are important in the pathogenesis of bowel injury , and that endotoxin and *induce* [PAF] formation in bowel tissue . Positive_regulation PAF1 TNF 7882905 289171 Because the release of [PAF] is *stimulated* by , this study was designed to measure the effects of polyI : C on TNF induced lung inflammation and injury . Positive_regulation PAF1 TNF 8080039 270821 Interleukin-1 beta and *induce* [PAF] production by endothelium , and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist . Positive_regulation PAF1 TNF 9394802 468196 These data suggest that [PAF] , which is released immediately or shortly after LPS injection , *induces* the expression of through the activation of NF-kappa B . Positive_regulation PAFAH1B1 IFI27 19615744 2208882 We investigated whether , in [myelodysplastic syndromes (MDS)] , aberrant expression of miR-150/miR-221/miR-222 and their designated target mRNA molecules MYB , and c-KIT may be *involved* in insufficient haematopoiesis . Positive_regulation PAFAH1B1 STK39 18083840 1837377 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation PAH ARSA 3912188 55187 Neither nor SA *caused* a significant change in urine volume , in the renal clearances of Na , K , free water , osmolality , creatinine , inulin and [p-aminohippurate (PAH)] or in plasma Li level . Positive_regulation PAH IL1B 18830893 1971138 [PAH] *induced* significant secretion of , IL-8 , and IL-12 after 24 or 48 hr of treatment , an effect reinforced by LPS stimulation ; Positive_regulation PAH TNF 21839840 2505624 Scallop [phenylalanine hydroxylase] implicates in immune response and can be *induced* by human . Positive_regulation PAIP1 TNF 12040173 949656 A common feature of each pathway is the *induced* formation of a [multiprotein] signaling complex at the cell membrane . Positive_regulation PAK1 ARSA 23146664 2722879 The mechanism of [PAK1] inhibition and *induction* of membranous translocation of adhesion proteins by <5-ASA> might be independent of its known anti-inflammatory action . Positive_regulation PAK1 EPHB2 12546821 1051225 Activation of the receptor *induces* translocation of the Rho-GEF kalirin to synapses and activation of Rac1 and its effector [PAK] . Positive_regulation PAK1 EPHB2 18586681 1953526 Inhibition of MAPK pathways showed that signaling but not p38 is *required* for full [PAK] activation and focal adhesion turnover . Positive_regulation PAK1 EPHB2 20526801 2320148 We conclude that [Rac1/Pak1] signaling is critical to MB cell migration and is functionally *dependent* on activity . Positive_regulation PAK1 GPR115 14695200 1180166 *Activation* of [p21 activated kinase 1-nuclear] factor kappaB signaling by Kaposi 's sarcoma associated herpes virus during cellular transformation . Positive_regulation PAK1 GPR132 14695200 1180155 *Activation* of [p21 activated kinase 1-nuclear] factor kappaB signaling by Kaposi 's sarcoma associated herpes virus during cellular transformation . Positive_regulation PAK1 GPR87 14695200 1180235 *Activation* of [p21 activated kinase 1-nuclear] factor kappaB signaling by Kaposi 's sarcoma associated herpes virus during cellular transformation . Positive_regulation PAK1 IL1B 9038353 415467 Endothelin-1 and , which also activate SAPKs/JNKs , did not *increase* [alpha PAK] activity and presumably act through different PAK isoforms or other mechanisms . Positive_regulation PAK1 MAP2K6 18586681 1953533 Inhibition of MAPK pathways showed that signaling but not p38 is *required* for full [PAK] activation and focal adhesion turnover . Positive_regulation PAK1 TNF 19298660 2056097 *induced* expression of matrix metalloproteinase-9 through [p21 activated kinase-1] . Positive_regulation PAK1 TNF 19298660 2056099 In *response* to or IL-1alpha , [PAK1] was promptly activated , as characterized by a sequential phosphorylation , initiated at threonine-212 followed by at threonine-423 in the activation loop of the kinase , in human skin keratinocytes , dermal fibroblasts , and rat hepatic stellate cells . Positive_regulation PAK1 TNF 22416254 2612624 Stimulation with IL-1ß or *up-regulated* [p-PAK1] expression . Positive_regulation PAK2 EPHB2 12546821 1051230 Activation of the receptor *induces* translocation of the Rho-GEF kalirin to synapses and activation of Rac1 and its effector [PAK] . Positive_regulation PAK2 EPHB2 18586681 1953535 Inhibition of MAPK pathways showed that signaling but not p38 is *required* for full [PAK] activation and focal adhesion turnover . Positive_regulation PAK2 F2R 24025335 2857095 Inhibition or depletion of also *blocked* thrombin induced activation of Pyk2 , Gab1 , p115 RhoGEF , Rac1 , RhoA , and [Pak2] , resulting in diminished THP-1 cell F-actin cytoskeletal remodeling and migration . Positive_regulation PAK2 MAP2K6 18586681 1953542 Inhibition of MAPK pathways showed that signaling but not p38 is *required* for full [PAK] activation and focal adhesion turnover . Positive_regulation PAK2 MMP28 20111678 2178739 In the present study , we examined the effects of resveratrol on apoptotic biochemical events in Hep G2 cells induced by CTN. Resveratrol inhibited CTN induced ROS generation , activation of JNK , loss of mitochondrial , as well as *activation* of caspase-9 , caspase-3 and [PAK2] . Positive_regulation PAK2 MMP7 20111678 2178754 In the present study , we examined the effects of resveratrol on apoptotic biochemical events in Hep G2 cells induced by CTN. Resveratrol inhibited CTN induced ROS generation , activation of JNK , loss of mitochondrial , as well as *activation* of caspase-9 , caspase-3 and [PAK2] . Positive_regulation PAK3 EPHB2 12546821 1051235 Activation of the receptor *induces* translocation of the Rho-GEF kalirin to synapses and activation of Rac1 and its effector [PAK] . Positive_regulation PAK3 EPHB2 18586681 1953544 Inhibition of MAPK pathways showed that signaling but not p38 is *required* for full [PAK] activation and focal adhesion turnover . Positive_regulation PAK3 MAP2K6 18586681 1953551 Inhibition of MAPK pathways showed that signaling but not p38 is *required* for full [PAK] activation and focal adhesion turnover . Positive_regulation PAK4 EPHB2 12546821 1051180 Activation of the receptor *induces* translocation of the Rho-GEF kalirin to synapses and activation of Rac1 and its effector [PAK] . Positive_regulation PAK4 EPHB2 18586681 1953508 Inhibition of MAPK pathways showed that signaling but not p38 is *required* for full [PAK] activation and focal adhesion turnover . Positive_regulation PAK4 MAP2K6 15550393 1367773 [PAK4] and PAK5 were similarly *activated* by , consistent with a conserved TPY motif in their activation domains . Positive_regulation PAK4 MAP2K6 18586681 1953515 Inhibition of MAPK pathways showed that signaling but not p38 is *required* for full [PAK] activation and focal adhesion turnover . Positive_regulation PAK4 TNF 23293332 2737825 *induced* a significant increase in the [Pak4] expression in endometrial cells in vitro , whereas IL-1ß had no effects . Positive_regulation PAK4 TNF 23293332 2737826 These findings suggest that [Pak4] is *regulated* by progesterone and in endometrial cells and that the increased expression of Pak4 might lead to the establishment and progression of endometriosis by enhanced cellular viability and invasiveness in endometrial cells . Positive_regulation PAK6 EPHB2 12546821 1051185 Activation of the receptor *induces* translocation of the Rho-GEF kalirin to synapses and activation of Rac1 and its effector [PAK] . Positive_regulation PAK6 EPHB2 18586681 1953517 Inhibition of MAPK pathways showed that signaling but not p38 is *required* for full [PAK] activation and focal adhesion turnover . Positive_regulation PAK6 MAP2K6 15550393 1367768 *Activation* of [p21 activated kinase 6] by and p38 MAP kinase . Positive_regulation PAK6 MAP2K6 15550393 1367770 This study found that basal [PAK6] kinase activity was repressed by a p38 mitogen activated protein (MAP) kinase antagonist and could be strongly *stimulated* by constitutively active , an upstream activator of p38 MAP kinases . Positive_regulation PAK6 MAP2K6 15550393 1367771 Moreover , [PAK6] was directly *activated* by , and mutation of tyrosine 566 in a consensus MKK6 site ( threonine-proline-tyrosine , TPY ) in the activation loop of the PAK6 kinase domain prevented activation by MKK6 . Positive_regulation PAK6 MAP2K6 15550393 1367772 [PAK6] *activation* by was also blocked by mutation of an autophosphorylated serine ( serine 560 ) in the PAK6 activation loop , indicating that phosphorylation of this site is necessary for MKK6 mediated activation . Positive_regulation PAK6 MAP2K6 15550393 1367774 PAK4 and [PAK5] were similarly *activated* by , consistent with a conserved TPY motif in their activation domains . Positive_regulation PAK6 MAP2K6 15550393 1367775 The *activation* of [PAK6] by both p38 MAP kinase and suggests that PAK6 plays a role in the cellular response to stress related signals . Positive_regulation PAK6 MAP2K6 18586681 1953524 Inhibition of MAPK pathways showed that signaling but not p38 is *required* for full [PAK] activation and focal adhesion turnover . Positive_regulation PAK7 EPHB2 12546821 1051175 Activation of the receptor *induces* translocation of the Rho-GEF kalirin to synapses and activation of Rac1 and its effector [PAK] . Positive_regulation PAK7 EPHB2 18586681 1953499 Inhibition of MAPK pathways showed that signaling but not p38 is *required* for full [PAK] activation and focal adhesion turnover . Positive_regulation PAK7 MAP2K6 18586681 1953506 Inhibition of MAPK pathways showed that signaling but not p38 is *required* for full [PAK] activation and focal adhesion turnover . Positive_regulation PALLD EPHB2 22216253 2519250 Suppression of activation by a chemical inhibitor *reduced* [palladin] phosphorylation , and expression of active MEK alone was sufficient for phosphorylation . Positive_regulation PAM F2R 15086339 1234689 In the murine keratinocyte cell line [PAM-212] *activation* of with specific activating peptides resulted in a calcium influx and an increase of proliferation , whereas activation of PAR-2 caused a diminished proliferation . Positive_regulation PAM TLR7 22235849 2591929 ligands , MALP2 , [Pam3CSK4] , LTA , and imiquimod induced high epithelial COX-2 expression , while zymosan and poly dI : dC *induced* very low enzyme expression . Positive_regulation PAM TNF 16783405 1599408 In contrast , S. aureus ( TLR2/TLR1/TLR6 ) or [Pam] ( 3 ) CSK4 ( TLR2/TLR1 ) , or FSL-1 and LTA ( TLR2/TLR6 ) *induced* without an effect on NO. 3 . Positive_regulation PAM TNF 23741282 2878221 [PAM] *induced* choroid plexus transcription of and resulted in the most dramatic increase in numbers of white blood cells in the CSF . Positive_regulation PAM TNF 9386357 466426 The PAM model suggested that and GM-CSF could *activate* [PAM] to restrict the intracellular growth of the bacteria , probably not through the superoxide anion release , but through the myeloperoxidasae-halide system . Positive_regulation PAM TNF 9826384 550594 Thus , augments the capacity of PMNs to damage Aspergillus hyphae , possibly through enhanced oxidative mechanisms , and *increases* [PAM] phagocytic activity against conidia . Positive_regulation PAN2 AGR2 8440343 213298 PM , but not 6-DMAP or [PAN] , inhibited [ 14C ] leucine incorporation , *induced* a time related cytotoxic effect , , a metaphase-mitotic-arrest , apoptosis and c-myc mRNA superinduction . Positive_regulation PAN3 AGR2 8440343 213299 PM , but not 6-DMAP or [PAN] , inhibited [ 14C ] leucine incorporation , *induced* a time related cytotoxic effect , , a metaphase-mitotic-arrest , apoptosis and c-myc mRNA superinduction . Positive_regulation PAPPA IL1B 14962808 1208745 Tumor necrosis factor alpha (TNFalpha) , , and IL-4 also *increased* [PAPP-A] expression 3- to 4-fold . Positive_regulation PAPPA IL1B 16269458 1509294 An inhibitor of p38 activation ( SB203580 ) had no effect on TNFalpha- or *stimulated* [PAPP-A] expression . Positive_regulation PAPPA IL1B 16269458 1509298 However , SP600125 effectively inhibited *induced* [PAPP-A] protein expression . Positive_regulation PAPPA IL1B 16269458 1509299 MG-132 , a proteasome inhibitor that blocked degradation of the intrinsic NFkappaB inhibitor , IkappaB , and thereby prevented NFkappaB activation , was a potent inhibitor of both TNFalpha- and *stimulated* [PAPP-A] mRNA and protein expression and IGF binding protein-4 protease activity . Positive_regulation PAPPA IL1B 16269458 1509303 BAY11-7082 , another inhibitor of NFkappaB activation , also inhibited TNFalpha- and *stimulated* [PAPP-A] expression and IGF binding protein-4 protease activity . Positive_regulation PAPPA IL1B 16338976 1503971 Interestingly , pretreatment of hCASMC with resveratrol , a polyphenol found in the skin of grapes and in red wine purported to underlie the `` French paradox , '' inhibited TNF-alpha- and *induced* [PAPP-A] expression and , hence , its IGFBP-4 proteolytic activity . Positive_regulation PAPPA IL1B 16338976 1503973 Our finding that [PAPP-A] gene expression in hCASMC is *stimulated* by TNF-alpha and suggests a mechanism for the regulation of PAPP-A in response to vascular injury that may contribute to the enhanced IGF-I bioactivity in intimal hyperplasia and atherosclerotic plaque development . Positive_regulation PAPPA TNF 14962808 1208744 , IL-1beta , and IL-4 also *increased* [PAPP-A] expression 3- to 4-fold . Positive_regulation PAPPA TNF 16269458 1509297 The JNK inhibitor , SP600125 , had no effect on IL-1beta- or *stimulated* [PAPP-A] mRNA expression . Positive_regulation PAPPA TNF 16338976 1503969 and interleukin (IL)-1beta *stimulated* [PAPP-A] gene expression in a time- and dose dependent manner . Positive_regulation PAPPA TNF 16338976 1503972 Our finding that [PAPP-A] gene expression in hCASMC is *stimulated* by and IL-1beta suggests a mechanism for the regulation of PAPP-A in response to vascular injury that may contribute to the enhanced IGF-I bioactivity in intimal hyperplasia and atherosclerotic plaque development . Positive_regulation PAPPA TNF 17936662 1888971 *Stimulation* of [PAPP-A] expression by was associated with significantly increased VCAM , ICAM , and MCP-1 expression but without major changes in other IGF system components . Positive_regulation PAPPA TNF 17936662 1888972 The anti-oxidant , N-acetyl cysteine , inhibited *induced* [PAPP-A] expression without altering the induction in VCAM , ICAM , and MCP-1 . Positive_regulation PAPPA TNF 22709655 2643915 Although *induced* [PAPP-A] expression in skeletal myoblast culture and its expression increased upon injury , abrogation of TNF-a signaling in TNF-a receptor knockout mice had no impact on the extent of injury induction of PAPP-A . Positive_regulation PAPPA TNF 22997483 2679086 CRP and *induce* [PAPP-A] expression in human peripheral blood mononuclear cells . Positive_regulation PARD6A F2R 11516655 851166 Although these PAR proteins therefore seem to play a conserved role in early anterior-posterior polarity in C. elegans and Drosophila , the relationships between them are different , as the localization of does not *require* Bazooka or [PAR-6] in Drosophila , as it does in the worm . Positive_regulation PARP1 CAPN8 19427306 2101253 Both calpain and [PARP-1] are involved with AIF processing as AIF truncation , nuclear translocation and neuronal death were *attenuated* by inhibition using adeno associated virus mediated overexpression of the endogenous calpain inhibitor , calpastatin , or treatment with the PARP-1 inhibitor 3-ABA . Positive_regulation PARP1 CCND1 20512478 2264107 The G(1)/S phase arrest was accompanied by down regulation of , one of the cyclins required for advance from G ( 1 ) to S. Subsequent apoptosis was *induced* by the gradual activation of caspase-3 and the cleavage of [PARP] . Positive_regulation PARP1 EPHB2 15178807 1280490 TPA treatment rapidly increased phosphorylation of , a reported downstream effector of both PKC and Rap1 , in ERC-18 cells , but induced weak [Rap1] *activation* . Positive_regulation PARP1 EPHB2 16152590 1517338 Bcl-2 phosphorylation and *activation* of and JNK and caspase 3-dependent cleavage of [PARP] were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation PARP1 EPHB2 16648609 1553345 Furthermore , the antioxidant N-acetyl-L-cysteine effectively blocked ajoene mediated ROS generation , *activation* of JNK and , translocation of AIF , and degradation of [PARP-1] . Positive_regulation PARP1 EPHB2 22391342 2587495 ERK inhibitor blocked the interaction of PARP-1 with ERK1/2 , phosphorylation of PARP-1 , and poly ( ADP-ribosyl ) ation of p65 , suggesting that *dependent* phosphorylation of [PARP-1] regulates PARP-1 activity and NF-?B activation . Positive_regulation PARP1 F2R 15078882 1251878 We found that , similarly to thrombin , selective stimulation of either or PAR-4 by specific activating peptides *caused* accumulation of GTP bound [Rap1B] in a dose dependent manner . Positive_regulation PARP1 F2R 15078882 1251892 In the presence of the ADP scavengers apyrase or phosphocreatine-phosphocreatine kinase , activation of [Rap1B] *induced* by stimulation of either or PAR-4 was totally inhibited . Positive_regulation PARP1 F2R 19483102 2107929 Perturbation of PI3K signaling by isoform-selective inhibitors had differential effects on [Rap1] *activation* through and PAR4 . Positive_regulation PARP1 F2R 24790104 2950504 Stimulation of the G-protein coupled receptor with thrombin in human 1321N1 glioblastoma cells *led* to a robust increase in [Rap1] activation . Positive_regulation PARP1 FAS 11259186 795752 The MC159 expressing virus blocked *induced* activation of caspase-3 and -8 , degradation of [PARP] , and cleavage of DNA , whereas the parental vaccinia virus did not . Positive_regulation PARP1 FAS 11907276 923556 TNF but not *mediated* [PARP] activation , whereas a PARP inhibitor suppressed TNF induced necrosis and the sensitizing effect of zVAD . Positive_regulation PARP1 FAS 23246487 2736933 Further studies with HCT8 cells showed that knockdown of FAM3B increased the protein levels of membrane bound and Bax , reduced the expression of Bcl-2 , *promoted* the cleavage of caspases-8 , -3 , -9 and [PARP] , and the nuclear translocation of cleaved PARP . Positive_regulation PARP1 FAS 9398401 468987 Ligation of CD40 potentiates mediated *activation* of the cysteine protease CPP32 , cleavage of its death substrate [PARP] , and apoptosis in Ramos-Burkitt lymphoma B cells . Positive_regulation PARP1 IL1B 17404069 1721536 Resveratrol inhibits *induced* stimulation of caspase-3 and cleavage of [PARP] in human articular chondrocytes in vitro . Positive_regulation PARP1 ITGAL 8871630 389564 Modification of *requires* expression of the cell surface [ADPRT] and causes the loss of epitopes recognized by alpha- and beta-chain-specific Abs. Concomitantly , the generation of inositol phosphates induced by Ab cross linking of LFA-1 is significantly inhibited . Positive_regulation PARP1 LBP 24595452 2920503 at the dose of 40 mg/kg significantly *suppressed* overexpression of Bax , CytC , Caspase-3 , -9 and cleaved [PARP-1] , and inhibited the reduction of Bcl-2 expression . Positive_regulation PARP1 MAP2K6 17295209 1771858 inhibitor PD 184352 also *reduced* [PARP] activation and improved LNCaP survival following EGF and IR treatment . Positive_regulation PARP1 MMP28 14766804 1227576 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP1 MMP7 14766804 1227591 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP1 TNF 11835405 911426 Additionally , TNF induced caspase-3 and caspase-8 activation and *induced* [PARP] cleavage were unaffected by the presence or absence of STAT1 . Positive_regulation PARP1 TNF 11907276 923582 Our results indicate that *induces* [PARP] activation leading to ATP depletion and subsequent necrosis . Positive_regulation PARP1 TNF 12829021 1105068 The cell lines overexpressing MnSOD ( 1F2 or 2C6 ) displayed decreased radiation induced , induced , or IL-3 withdrawal *induced* mitochondrial membrane permeability , caspase-3 and [PARP] activation , and apoptosis . Positive_regulation PARP1 TNF 15492857 1321715 As the molecular mechanism involved , we showed Delta-1 stimulation partially suppressed the sequential activation of caspase-8 , caspase-3 , and , [PARP] *induced* by . Positive_regulation PARP1 TNF 16043520 1437849 Both compounds blocked *induced* activation of [Rap1A] , a phox associated guanosine triphosphatase that is regulated by cAMP . Positive_regulation PARP1 TNF 19181934 2043856 Pre-exposure of cells to an IKK inhibitor ( PS-1145 ) prevented *induced* caspase-3 and [PARP] cleavage . Positive_regulation PARP1 TNF 19447888 2107169 Moreover , we found that *enhanced* MOR gene expression as well as increased [PARP-1] binding to the G ( -172 ) -- > T region and G ( -172 ) -- > T-dependent transcription in SH-SY5Y cells . Positive_regulation PARP1 TNF 20236182 2237972 DEC2 over-expression caused by the transfection of an expression vector reduced the amounts of cleaved [PARP] and caspase-8 *induced* by treatment , whereas DEC1 over-expression increased it . Positive_regulation PARP1 TNF 21188622 2402178 Gomisins A and N strongly promoted *induced* cleavage of caspase-3 and [PARP-1] , which are key markers of apoptosis . Positive_regulation PARP1 TNFSF10 11964312 932777 While it had no activity alone , ectopic overexpression of Smac/DIABLO or treatment with the N-terminus heptapeptide ( Smac-7 ) or tetrapeptide ( Smac-4 ) of Smac/DIABLO significantly increased Epo B- or *induced* processing and [PARP] cleavage activity of caspase-3 . Positive_regulation PARP1 TNFSF10 17273769 1691735 Fenretinide and cooperatively *activated* caspase-3 , -8 , -10 and -9 and cleavage of Bid and [PARP] , and this activation was also blocked in the presence of DR5/Fc chimeric protein . Positive_regulation PARP1 TNFSF10 20667470 2317065 The pro-survival effect is associated with an increased expression of the inhibitor of apoptosis protein-1 ( c-IAP1 ) , a decrease of *induced* cleavage of [PARP] , procaspase 9 and procaspase 3 , and a decrease of cytochrome C release from the mitochondria . Positive_regulation PARP1 TNFSF10 22982206 2716113 We first found that VA induces a major molecule of ER stress , CCAAT/enhancer binding protein homologous protein ( CHOP ) -dependent DR5 induction and subsequently increases *induced* cleavage of caspases and [PARP] in TRAIL-resistant Hep3B cells . Positive_regulation PARP10 CCND1 20512478 2264102 The G(1)/S phase arrest was accompanied by down regulation of , one of the cyclins required for advance from G ( 1 ) to S. Subsequent apoptosis was *induced* by the gradual activation of caspase-3 and the cleavage of [PARP] . Positive_regulation PARP10 EPHB2 16152590 1517333 Bcl-2 phosphorylation and *activation* of and JNK and caspase 3-dependent cleavage of [PARP] were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation PARP10 FAS 11259186 795747 The MC159 expressing virus blocked *induced* activation of caspase-3 and -8 , degradation of [PARP] , and cleavage of DNA , whereas the parental vaccinia virus did not . Positive_regulation PARP10 FAS 11907276 923551 TNF but not *mediated* [PARP] activation , whereas a PARP inhibitor suppressed TNF induced necrosis and the sensitizing effect of zVAD . Positive_regulation PARP10 FAS 23246487 2736923 Further studies with HCT8 cells showed that knockdown of FAM3B increased the protein levels of membrane bound and Bax , reduced the expression of Bcl-2 , *promoted* the cleavage of caspases-8 , -3 , -9 and [PARP] , and the nuclear translocation of cleaved PARP . Positive_regulation PARP10 FAS 9398401 468982 Ligation of CD40 potentiates *mediated* activation of the cysteine protease CPP32 , cleavage of its death substrate [PARP] , and apoptosis in Ramos-Burkitt lymphoma B cells . Positive_regulation PARP10 IL1B 17404069 1721531 Resveratrol inhibits *induced* stimulation of caspase-3 and cleavage of [PARP] in human articular chondrocytes in vitro . Positive_regulation PARP10 MAP2K6 17295209 1771823 inhibitor PD 184352 also *reduced* [PARP] activation and improved LNCaP survival following EGF and IR treatment . Positive_regulation PARP10 MMP28 14766804 1227466 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP10 MMP7 14766804 1227481 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP10 TNF 11835405 911421 Additionally , TNF induced caspase-3 and caspase-8 activation and *induced* [PARP] cleavage were unaffected by the presence or absence of STAT1 . Positive_regulation PARP10 TNF 11907276 923577 Our results indicate that *induces* [PARP] activation leading to ATP depletion and subsequent necrosis . Positive_regulation PARP10 TNF 12829021 1105058 The cell lines overexpressing MnSOD ( 1F2 or 2C6 ) displayed decreased radiation induced , induced , or IL-3 withdrawal *induced* mitochondrial membrane permeability , caspase-3 and [PARP] activation , and apoptosis . Positive_regulation PARP10 TNF 15492857 1321710 As the molecular mechanism involved , we showed Delta-1 stimulation partially suppressed the sequential activation of caspase-8 , caspase-3 , and , [PARP] *induced* by . Positive_regulation PARP10 TNF 19181934 2043851 Pre-exposure of cells to an IKK inhibitor ( PS-1145 ) prevented *induced* caspase-3 and [PARP] cleavage . Positive_regulation PARP10 TNF 20236182 2237967 DEC2 over-expression caused by the transfection of an expression vector reduced the amounts of cleaved [PARP] and caspase-8 *induced* by treatment , whereas DEC1 over-expression increased it . Positive_regulation PARP10 TNFSF10 11964312 932772 While it had no activity alone , ectopic overexpression of Smac/DIABLO or treatment with the N-terminus heptapeptide ( Smac-7 ) or tetrapeptide ( Smac-4 ) of Smac/DIABLO significantly increased Epo B- or *induced* processing and [PARP] cleavage activity of caspase-3 . Positive_regulation PARP10 TNFSF10 17273769 1691730 Fenretinide and cooperatively *activated* caspase-3 , -8 , -10 and -9 and cleavage of Bid and [PARP] , and this activation was also blocked in the presence of DR5/Fc chimeric protein . Positive_regulation PARP10 TNFSF10 20667470 2317060 The pro-survival effect is associated with an increased expression of the inhibitor of apoptosis protein-1 ( c-IAP1 ) , a decrease of *induced* cleavage of [PARP] , procaspase 9 and procaspase 3 , and a decrease of cytochrome C release from the mitochondria . Positive_regulation PARP10 TNFSF10 22982206 2716108 We first found that VA induces a major molecule of ER stress , CCAAT/enhancer binding protein homologous protein ( CHOP ) -dependent DR5 induction and subsequently increases *induced* cleavage of caspases and [PARP] in TRAIL-resistant Hep3B cells . Positive_regulation PARP11 CCND1 20512478 2264098 The G(1)/S phase arrest was accompanied by down regulation of , one of the cyclins required for advance from G ( 1 ) to S. Subsequent apoptosis was *induced* by the gradual activation of caspase-3 and the cleavage of [PARP] . Positive_regulation PARP11 EPHB2 16152590 1517329 Bcl-2 phosphorylation and *activation* of and JNK and caspase 3-dependent cleavage of [PARP] were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation PARP11 FAS 11259186 795742 The MC159 expressing virus blocked *induced* activation of caspase-3 and -8 , degradation of [PARP] , and cleavage of DNA , whereas the parental vaccinia virus did not . Positive_regulation PARP11 FAS 11907276 923548 TNF but not *mediated* [PARP] activation , whereas a PARP inhibitor suppressed TNF induced necrosis and the sensitizing effect of zVAD . Positive_regulation PARP11 FAS 23246487 2736917 Further studies with HCT8 cells showed that knockdown of FAM3B increased the protein levels of membrane bound and Bax , reduced the expression of Bcl-2 , *promoted* the cleavage of caspases-8 , -3 , -9 and [PARP] , and the nuclear translocation of cleaved PARP . Positive_regulation PARP11 FAS 9398401 468978 Ligation of CD40 potentiates *mediated* activation of the cysteine protease CPP32 , cleavage of its death substrate [PARP] , and apoptosis in Ramos-Burkitt lymphoma B cells . Positive_regulation PARP11 IL1B 17404069 1721527 Resveratrol inhibits *induced* stimulation of caspase-3 and cleavage of [PARP] in human articular chondrocytes in vitro . Positive_regulation PARP11 MAP2K6 17295209 1771802 inhibitor PD 184352 also *reduced* [PARP] activation and improved LNCaP survival following EGF and IR treatment . Positive_regulation PARP11 MMP28 14766804 1227400 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP11 MMP7 14766804 1227415 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP11 TNF 11835405 911416 Additionally , *induced* caspase-3 and caspase-8 activation and TNF induced [PARP] cleavage were unaffected by the presence or absence of STAT1 . Positive_regulation PARP11 TNF 11907276 923561 Our results indicate that *induces* [PARP] activation leading to ATP depletion and subsequent necrosis . Positive_regulation PARP11 TNF 12829021 1105050 The cell lines overexpressing MnSOD ( 1F2 or 2C6 ) displayed decreased radiation induced , induced , or IL-3 withdrawal *induced* mitochondrial membrane permeability , caspase-3 and [PARP] activation , and apoptosis . Positive_regulation PARP11 TNF 15492857 1321706 As the molecular mechanism involved , we showed Delta-1 stimulation partially suppressed the sequential activation of caspase-8 , caspase-3 , and , [PARP] *induced* by . Positive_regulation PARP11 TNF 19181934 2043847 Pre-exposure of cells to an IKK inhibitor ( PS-1145 ) prevented *induced* caspase-3 and [PARP] cleavage . Positive_regulation PARP11 TNF 20236182 2237963 DEC2 over-expression caused by the transfection of an expression vector reduced the amounts of cleaved [PARP] and caspase-8 *induced* by treatment , whereas DEC1 over-expression increased it . Positive_regulation PARP11 TNFSF10 11964312 932769 While it had no activity alone , ectopic overexpression of Smac/DIABLO or treatment with the N-terminus heptapeptide ( Smac-7 ) or tetrapeptide ( Smac-4 ) of Smac/DIABLO significantly increased Epo B- or *induced* processing and [PARP] cleavage activity of caspase-3 . Positive_regulation PARP11 TNFSF10 17273769 1691726 Fenretinide and cooperatively *activated* caspase-3 , -8 , -10 and -9 and cleavage of Bid and [PARP] , and this activation was also blocked in the presence of DR5/Fc chimeric protein . Positive_regulation PARP11 TNFSF10 20667470 2317057 The pro-survival effect is associated with an increased expression of the inhibitor of apoptosis protein-1 ( c-IAP1 ) , a decrease of *induced* cleavage of [PARP] , procaspase 9 and procaspase 3 , and a decrease of cytochrome C release from the mitochondria . Positive_regulation PARP11 TNFSF10 22982206 2716105 We first found that VA induces a major molecule of ER stress , CCAAT/enhancer binding protein homologous protein ( CHOP ) -dependent DR5 induction and subsequently increases *induced* cleavage of caspases and [PARP] in TRAIL-resistant Hep3B cells . Positive_regulation PARP12 CCND1 20512478 2264100 The G(1)/S phase arrest was accompanied by down regulation of , one of the cyclins required for advance from G ( 1 ) to S. Subsequent apoptosis was *induced* by the gradual activation of caspase-3 and the cleavage of [PARP] . Positive_regulation PARP12 EPHB2 16152590 1517331 Bcl-2 phosphorylation and *activation* of and JNK and caspase 3-dependent cleavage of [PARP] were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation PARP12 FAS 11259186 795745 The MC159 expressing virus blocked *induced* activation of caspase-3 and -8 , degradation of [PARP] , and cleavage of DNA , whereas the parental vaccinia virus did not . Positive_regulation PARP12 FAS 11907276 923549 TNF but not *mediated* [PARP] activation , whereas a PARP inhibitor suppressed TNF induced necrosis and the sensitizing effect of zVAD . Positive_regulation PARP12 FAS 23246487 2736919 Further studies with HCT8 cells showed that knockdown of FAM3B increased the protein levels of membrane bound and Bax , reduced the expression of Bcl-2 , *promoted* the cleavage of caspases-8 , -3 , -9 and [PARP] , and the nuclear translocation of cleaved PARP . Positive_regulation PARP12 FAS 9398401 468980 Ligation of CD40 potentiates *mediated* activation of the cysteine protease CPP32 , cleavage of its death substrate [PARP] , and apoptosis in Ramos-Burkitt lymphoma B cells . Positive_regulation PARP12 IL1B 17404069 1721529 Resveratrol inhibits *induced* stimulation of caspase-3 and cleavage of [PARP] in human articular chondrocytes in vitro . Positive_regulation PARP12 MAP2K6 17295209 1771809 inhibitor PD 184352 also *reduced* [PARP] activation and improved LNCaP survival following EGF and IR treatment . Positive_regulation PARP12 MMP28 14766804 1227422 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP12 MMP7 14766804 1227437 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP12 TNF 11835405 911419 Additionally , TNF induced caspase-3 and caspase-8 activation and *induced* [PARP] cleavage were unaffected by the presence or absence of STAT1 . Positive_regulation PARP12 TNF 11907276 923575 Our results indicate that *induces* [PARP] activation leading to ATP depletion and subsequent necrosis . Positive_regulation PARP12 TNF 12829021 1105054 The cell lines overexpressing MnSOD ( 1F2 or 2C6 ) displayed decreased radiation induced , induced , or IL-3 withdrawal *induced* mitochondrial membrane permeability , caspase-3 and [PARP] activation , and apoptosis . Positive_regulation PARP12 TNF 15492857 1321708 As the molecular mechanism involved , we showed Delta-1 stimulation partially suppressed the sequential activation of caspase-8 , caspase-3 , and , [PARP] *induced* by . Positive_regulation PARP12 TNF 19181934 2043849 Pre-exposure of cells to an IKK inhibitor ( PS-1145 ) prevented *induced* caspase-3 and [PARP] cleavage . Positive_regulation PARP12 TNF 20236182 2237965 DEC2 over-expression caused by the transfection of an expression vector reduced the amounts of cleaved [PARP] and caspase-8 *induced* by treatment , whereas DEC1 over-expression increased it . Positive_regulation PARP12 TNFSF10 11964312 932770 While it had no activity alone , ectopic overexpression of Smac/DIABLO or treatment with the N-terminus heptapeptide ( Smac-7 ) or tetrapeptide ( Smac-4 ) of Smac/DIABLO significantly increased Epo B- or *induced* processing and [PARP] cleavage activity of caspase-3 . Positive_regulation PARP12 TNFSF10 17273769 1691728 Fenretinide and cooperatively *activated* caspase-3 , -8 , -10 and -9 and cleavage of Bid and [PARP] , and this activation was also blocked in the presence of DR5/Fc chimeric protein . Positive_regulation PARP12 TNFSF10 20667470 2317058 The pro-survival effect is associated with an increased expression of the inhibitor of apoptosis protein-1 ( c-IAP1 ) , a decrease of *induced* cleavage of [PARP] , procaspase 9 and procaspase 3 , and a decrease of cytochrome C release from the mitochondria . Positive_regulation PARP12 TNFSF10 22982206 2716106 We first found that VA induces a major molecule of ER stress , CCAAT/enhancer binding protein homologous protein ( CHOP ) -dependent DR5 induction and subsequently increases *induced* cleavage of caspases and [PARP] in TRAIL-resistant Hep3B cells . Positive_regulation PARP14 CCND1 20512478 2264111 The G(1)/S phase arrest was accompanied by down regulation of , one of the cyclins required for advance from G ( 1 ) to S. Subsequent apoptosis was *induced* by the gradual activation of caspase-3 and the cleavage of [PARP] . Positive_regulation PARP14 EPHB2 16152590 1517342 Bcl-2 phosphorylation and *activation* of and JNK and caspase 3-dependent cleavage of [PARP] were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation PARP14 FAS 11259186 795756 The MC159 expressing virus blocked *induced* activation of caspase-3 and -8 , degradation of [PARP] , and cleavage of DNA , whereas the parental vaccinia virus did not . Positive_regulation PARP14 FAS 11907276 923560 TNF but not *mediated* [PARP] activation , whereas a PARP inhibitor suppressed TNF induced necrosis and the sensitizing effect of zVAD . Positive_regulation PARP14 FAS 23246487 2736941 Further studies with HCT8 cells showed that knockdown of FAM3B increased the protein levels of membrane bound and Bax , reduced the expression of Bcl-2 , *promoted* the cleavage of caspases-8 , -3 , -9 and [PARP] , and the nuclear translocation of cleaved PARP . Positive_regulation PARP14 FAS 9398401 468991 Ligation of CD40 potentiates mediated *activation* of the cysteine protease CPP32 , cleavage of its death substrate [PARP] , and apoptosis in Ramos-Burkitt lymphoma B cells . Positive_regulation PARP14 IL1B 17404069 1721540 Resveratrol inhibits *induced* stimulation of caspase-3 and cleavage of [PARP] in human articular chondrocytes in vitro . Positive_regulation PARP14 MAP2K6 17295209 1771886 inhibitor PD 184352 also *reduced* [PARP] activation and improved LNCaP survival following EGF and IR treatment . Positive_regulation PARP14 MMP28 14766804 1227664 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP14 MMP7 14766804 1227679 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP14 TNF 11835405 911430 Additionally , TNF induced caspase-3 and caspase-8 activation and *induced* [PARP] cleavage were unaffected by the presence or absence of STAT1 . Positive_regulation PARP14 TNF 11907276 923586 Our results indicate that *induces* [PARP] activation leading to ATP depletion and subsequent necrosis . Positive_regulation PARP14 TNF 12829021 1105076 The cell lines overexpressing MnSOD ( 1F2 or 2C6 ) displayed decreased radiation induced , induced , or IL-3 withdrawal *induced* mitochondrial membrane permeability , caspase-3 and [PARP] activation , and apoptosis . Positive_regulation PARP14 TNF 15492857 1321719 As the molecular mechanism involved , we showed Delta-1 stimulation partially suppressed the sequential activation of caspase-8 , caspase-3 , and , [PARP] *induced* by . Positive_regulation PARP14 TNF 19181934 2043860 Pre-exposure of cells to an IKK inhibitor ( PS-1145 ) prevented *induced* caspase-3 and [PARP] cleavage . Positive_regulation PARP14 TNF 20236182 2237976 DEC2 over-expression caused by the transfection of an expression vector reduced the amounts of cleaved [PARP] and caspase-8 *induced* by treatment , whereas DEC1 over-expression increased it . Positive_regulation PARP14 TNFSF10 11964312 932781 While it had no activity alone , ectopic overexpression of Smac/DIABLO or treatment with the N-terminus heptapeptide ( Smac-7 ) or tetrapeptide ( Smac-4 ) of Smac/DIABLO significantly increased Epo B- or *induced* processing and [PARP] cleavage activity of caspase-3 . Positive_regulation PARP14 TNFSF10 17273769 1691739 Fenretinide and cooperatively *activated* caspase-3 , -8 , -10 and -9 and cleavage of Bid and [PARP] , and this activation was also blocked in the presence of DR5/Fc chimeric protein . Positive_regulation PARP14 TNFSF10 20667470 2317069 The pro-survival effect is associated with an increased expression of the inhibitor of apoptosis protein-1 ( c-IAP1 ) , a decrease of *induced* cleavage of [PARP] , procaspase 9 and procaspase 3 , and a decrease of cytochrome C release from the mitochondria . Positive_regulation PARP14 TNFSF10 22982206 2716117 We first found that VA induces a major molecule of ER stress , CCAAT/enhancer binding protein homologous protein ( CHOP ) -dependent DR5 induction and subsequently increases *induced* cleavage of caspases and [PARP] in TRAIL-resistant Hep3B cells . Positive_regulation PARP15 CCND1 20512478 2264105 The G(1)/S phase arrest was accompanied by down regulation of , one of the cyclins required for advance from G ( 1 ) to S. Subsequent apoptosis was *induced* by the gradual activation of caspase-3 and the cleavage of [PARP] . Positive_regulation PARP15 EPHB2 16152590 1517336 Bcl-2 phosphorylation and *activation* of and JNK and caspase 3-dependent cleavage of [PARP] were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation PARP15 FAS 11259186 795750 The MC159 expressing virus blocked *induced* activation of caspase-3 and -8 , degradation of [PARP] , and cleavage of DNA , whereas the parental vaccinia virus did not . Positive_regulation PARP15 FAS 11907276 923554 TNF but not *mediated* [PARP] activation , whereas a PARP inhibitor suppressed TNF induced necrosis and the sensitizing effect of zVAD . Positive_regulation PARP15 FAS 23246487 2736929 Further studies with HCT8 cells showed that knockdown of FAM3B increased the protein levels of membrane bound and Bax , reduced the expression of Bcl-2 , *promoted* the cleavage of caspases-8 , -3 , -9 and [PARP] , and the nuclear translocation of cleaved PARP . Positive_regulation PARP15 FAS 9398401 468985 Ligation of CD40 potentiates mediated *activation* of the cysteine protease CPP32 , cleavage of its death substrate [PARP] , and apoptosis in Ramos-Burkitt lymphoma B cells . Positive_regulation PARP15 IL1B 17404069 1721534 Resveratrol inhibits *induced* stimulation of caspase-3 and cleavage of [PARP] in human articular chondrocytes in vitro . Positive_regulation PARP15 MAP2K6 17295209 1771844 inhibitor PD 184352 also *reduced* [PARP] activation and improved LNCaP survival following EGF and IR treatment . Positive_regulation PARP15 MMP28 14766804 1227532 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP15 MMP7 14766804 1227547 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP15 TNF 11835405 911424 Additionally , TNF induced caspase-3 and caspase-8 activation and *induced* [PARP] cleavage were unaffected by the presence or absence of STAT1 . Positive_regulation PARP15 TNF 11907276 923580 Our results indicate that *induces* [PARP] activation leading to ATP depletion and subsequent necrosis . Positive_regulation PARP15 TNF 12829021 1105064 The cell lines overexpressing MnSOD ( 1F2 or 2C6 ) displayed decreased radiation induced , induced , or IL-3 withdrawal *induced* mitochondrial membrane permeability , caspase-3 and [PARP] activation , and apoptosis . Positive_regulation PARP15 TNF 15492857 1321713 As the molecular mechanism involved , we showed Delta-1 stimulation partially suppressed the sequential activation of caspase-8 , caspase-3 , and , [PARP] *induced* by . Positive_regulation PARP15 TNF 19181934 2043854 Pre-exposure of cells to an IKK inhibitor ( PS-1145 ) prevented *induced* caspase-3 and [PARP] cleavage . Positive_regulation PARP15 TNF 20236182 2237970 DEC2 over-expression caused by the transfection of an expression vector reduced the amounts of cleaved [PARP] and caspase-8 *induced* by treatment , whereas DEC1 over-expression increased it . Positive_regulation PARP15 TNFSF10 11964312 932775 While it had no activity alone , ectopic overexpression of Smac/DIABLO or treatment with the N-terminus heptapeptide ( Smac-7 ) or tetrapeptide ( Smac-4 ) of Smac/DIABLO significantly increased Epo B- or *induced* processing and [PARP] cleavage activity of caspase-3 . Positive_regulation PARP15 TNFSF10 17273769 1691733 Fenretinide and cooperatively *activated* caspase-3 , -8 , -10 and -9 and cleavage of Bid and [PARP] , and this activation was also blocked in the presence of DR5/Fc chimeric protein . Positive_regulation PARP15 TNFSF10 20667470 2317063 The pro-survival effect is associated with an increased expression of the inhibitor of apoptosis protein-1 ( c-IAP1 ) , a decrease of *induced* cleavage of [PARP] , procaspase 9 and procaspase 3 , and a decrease of cytochrome C release from the mitochondria . Positive_regulation PARP15 TNFSF10 22982206 2716111 We first found that VA induces a major molecule of ER stress , CCAAT/enhancer binding protein homologous protein ( CHOP ) -dependent DR5 induction and subsequently increases *induced* cleavage of caspases and [PARP] in TRAIL-resistant Hep3B cells . Positive_regulation PARP16 CCND1 20512478 2264103 The G(1)/S phase arrest was accompanied by down regulation of , one of the cyclins required for advance from G ( 1 ) to S. Subsequent apoptosis was *induced* by the gradual activation of caspase-3 and the cleavage of [PARP] . Positive_regulation PARP16 EPHB2 16152590 1517334 Bcl-2 phosphorylation and *activation* of and JNK and caspase 3-dependent cleavage of [PARP] were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation PARP16 FAS 11259186 795748 The MC159 expressing virus blocked *induced* activation of caspase-3 and -8 , degradation of [PARP] , and cleavage of DNA , whereas the parental vaccinia virus did not . Positive_regulation PARP16 FAS 11907276 923552 TNF but not *mediated* [PARP] activation , whereas a PARP inhibitor suppressed TNF induced necrosis and the sensitizing effect of zVAD . Positive_regulation PARP16 FAS 23246487 2736925 Further studies with HCT8 cells showed that knockdown of FAM3B increased the protein levels of membrane bound and Bax , reduced the expression of Bcl-2 , *promoted* the cleavage of caspases-8 , -3 , -9 and [PARP] , and the nuclear translocation of cleaved PARP . Positive_regulation PARP16 FAS 9398401 468983 Ligation of CD40 potentiates mediated *activation* of the cysteine protease CPP32 , cleavage of its death substrate [PARP] , and apoptosis in Ramos-Burkitt lymphoma B cells . Positive_regulation PARP16 IL1B 17404069 1721532 Resveratrol inhibits *induced* stimulation of caspase-3 and cleavage of [PARP] in human articular chondrocytes in vitro . Positive_regulation PARP16 MAP2K6 17295209 1771830 inhibitor PD 184352 also *reduced* [PARP] activation and improved LNCaP survival following EGF and IR treatment . Positive_regulation PARP16 MMP28 14766804 1227488 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP16 MMP7 14766804 1227503 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP16 TNF 11835405 911422 Additionally , *induced* caspase-3 and caspase-8 activation and TNF induced [PARP] cleavage were unaffected by the presence or absence of STAT1 . Positive_regulation PARP16 TNF 11907276 923578 Our results indicate that *induces* [PARP] activation leading to ATP depletion and subsequent necrosis . Positive_regulation PARP16 TNF 12829021 1105060 The cell lines overexpressing MnSOD ( 1F2 or 2C6 ) displayed decreased radiation induced , induced , or IL-3 withdrawal *induced* mitochondrial membrane permeability , caspase-3 and [PARP] activation , and apoptosis . Positive_regulation PARP16 TNF 15492857 1321711 As the molecular mechanism involved , we showed Delta-1 stimulation partially suppressed the sequential activation of caspase-8 , caspase-3 , and , [PARP] *induced* by . Positive_regulation PARP16 TNF 19181934 2043852 Pre-exposure of cells to an IKK inhibitor ( PS-1145 ) prevented *induced* caspase-3 and [PARP] cleavage . Positive_regulation PARP16 TNF 20236182 2237968 DEC2 over-expression caused by the transfection of an expression vector reduced the amounts of cleaved [PARP] and caspase-8 *induced* by treatment , whereas DEC1 over-expression increased it . Positive_regulation PARP16 TNFSF10 11964312 932773 While it had no activity alone , ectopic overexpression of Smac/DIABLO or treatment with the N-terminus heptapeptide ( Smac-7 ) or tetrapeptide ( Smac-4 ) of Smac/DIABLO significantly increased Epo B- or *induced* processing and [PARP] cleavage activity of caspase-3 . Positive_regulation PARP16 TNFSF10 17273769 1691731 Fenretinide and cooperatively *activated* caspase-3 , -8 , -10 and -9 and cleavage of Bid and [PARP] , and this activation was also blocked in the presence of DR5/Fc chimeric protein . Positive_regulation PARP16 TNFSF10 20667470 2317061 The pro-survival effect is associated with an increased expression of the inhibitor of apoptosis protein-1 ( c-IAP1 ) , a decrease of *induced* cleavage of [PARP] , procaspase 9 and procaspase 3 , and a decrease of cytochrome C release from the mitochondria . Positive_regulation PARP16 TNFSF10 22982206 2716109 We first found that VA induces a major molecule of ER stress , CCAAT/enhancer binding protein homologous protein ( CHOP ) -dependent DR5 induction and subsequently increases *induced* cleavage of caspases and [PARP] in TRAIL-resistant Hep3B cells . Positive_regulation PARP2 CCND1 20512478 2264109 The G(1)/S phase arrest was accompanied by down regulation of , one of the cyclins required for advance from G ( 1 ) to S. Subsequent apoptosis was *induced* by the gradual activation of caspase-3 and the cleavage of [PARP] . Positive_regulation PARP2 EPHB2 16152590 1517340 Bcl-2 phosphorylation and *activation* of and JNK and caspase 3-dependent cleavage of [PARP] were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation PARP2 FAS 11259186 795754 The MC159 expressing virus blocked *induced* activation of caspase-3 and -8 , degradation of [PARP] , and cleavage of DNA , whereas the parental vaccinia virus did not . Positive_regulation PARP2 FAS 11907276 923558 TNF but not *mediated* [PARP] activation , whereas a PARP inhibitor suppressed TNF induced necrosis and the sensitizing effect of zVAD . Positive_regulation PARP2 FAS 23246487 2736937 Further studies with HCT8 cells showed that knockdown of FAM3B increased the protein levels of membrane bound and Bax , reduced the expression of Bcl-2 , *promoted* the cleavage of caspases-8 , -3 , -9 and [PARP] , and the nuclear translocation of cleaved PARP . Positive_regulation PARP2 FAS 9398401 468989 Ligation of CD40 potentiates mediated *activation* of the cysteine protease CPP32 , cleavage of its death substrate [PARP] , and apoptosis in Ramos-Burkitt lymphoma B cells . Positive_regulation PARP2 IL1B 17404069 1721538 Resveratrol inhibits *induced* stimulation of caspase-3 and cleavage of [PARP] in human articular chondrocytes in vitro . Positive_regulation PARP2 MAP2K6 17295209 1771872 inhibitor PD 184352 also *reduced* [PARP] activation and improved LNCaP survival following EGF and IR treatment . Positive_regulation PARP2 MMP28 14766804 1227620 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP2 MMP7 14766804 1227635 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP2 TNF 11835405 911428 Additionally , TNF induced caspase-3 and caspase-8 activation and *induced* [PARP] cleavage were unaffected by the presence or absence of STAT1 . Positive_regulation PARP2 TNF 11907276 923584 Our results indicate that *induces* [PARP] activation leading to ATP depletion and subsequent necrosis . Positive_regulation PARP2 TNF 12829021 1105072 The cell lines overexpressing MnSOD ( 1F2 or 2C6 ) displayed decreased radiation induced , induced , or IL-3 withdrawal *induced* mitochondrial membrane permeability , caspase-3 and [PARP] activation , and apoptosis . Positive_regulation PARP2 TNF 15492857 1321717 As the molecular mechanism involved , we showed Delta-1 stimulation partially suppressed the sequential activation of caspase-8 , caspase-3 , and , [PARP] *induced* by . Positive_regulation PARP2 TNF 19181934 2043858 Pre-exposure of cells to an IKK inhibitor ( PS-1145 ) prevented *induced* caspase-3 and [PARP] cleavage . Positive_regulation PARP2 TNF 20236182 2237974 DEC2 over-expression caused by the transfection of an expression vector reduced the amounts of cleaved [PARP] and caspase-8 *induced* by treatment , whereas DEC1 over-expression increased it . Positive_regulation PARP2 TNFSF10 11964312 932779 While it had no activity alone , ectopic overexpression of Smac/DIABLO or treatment with the N-terminus heptapeptide ( Smac-7 ) or tetrapeptide ( Smac-4 ) of Smac/DIABLO significantly increased Epo B- or *induced* processing and [PARP] cleavage activity of caspase-3 . Positive_regulation PARP2 TNFSF10 17273769 1691737 Fenretinide and cooperatively *activated* caspase-3 , -8 , -10 and -9 and cleavage of Bid and [PARP] , and this activation was also blocked in the presence of DR5/Fc chimeric protein . Positive_regulation PARP2 TNFSF10 20667470 2317067 The pro-survival effect is associated with an increased expression of the inhibitor of apoptosis protein-1 ( c-IAP1 ) , a decrease of *induced* cleavage of [PARP] , procaspase 9 and procaspase 3 , and a decrease of cytochrome C release from the mitochondria . Positive_regulation PARP2 TNFSF10 22982206 2716115 We first found that VA induces a major molecule of ER stress , CCAAT/enhancer binding protein homologous protein ( CHOP ) -dependent DR5 induction and subsequently increases *induced* cleavage of caspases and [PARP] in TRAIL-resistant Hep3B cells . Positive_regulation PARP3 CCND1 20512478 2264110 The G(1)/S phase arrest was accompanied by down regulation of , one of the cyclins required for advance from G ( 1 ) to S. Subsequent apoptosis was *induced* by the gradual activation of caspase-3 and the cleavage of [PARP] . Positive_regulation PARP3 EPHB2 16152590 1517341 Bcl-2 phosphorylation and *activation* of and JNK and caspase 3-dependent cleavage of [PARP] were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation PARP3 FAS 11259186 795755 The MC159 expressing virus blocked *induced* activation of caspase-3 and -8 , degradation of [PARP] , and cleavage of DNA , whereas the parental vaccinia virus did not . Positive_regulation PARP3 FAS 11907276 923559 TNF but not *mediated* [PARP] activation , whereas a PARP inhibitor suppressed TNF induced necrosis and the sensitizing effect of zVAD . Positive_regulation PARP3 FAS 23246487 2736939 Further studies with HCT8 cells showed that knockdown of FAM3B increased the protein levels of membrane bound and Bax , reduced the expression of Bcl-2 , *promoted* the cleavage of caspases-8 , -3 , -9 and [PARP] , and the nuclear translocation of cleaved PARP . Positive_regulation PARP3 FAS 9398401 468990 Ligation of CD40 potentiates *mediated* activation of the cysteine protease CPP32 , cleavage of its death substrate [PARP] , and apoptosis in Ramos-Burkitt lymphoma B cells . Positive_regulation PARP3 IL1B 17404069 1721539 Resveratrol inhibits *induced* stimulation of caspase-3 and cleavage of [PARP] in human articular chondrocytes in vitro . Positive_regulation PARP3 MAP2K6 17295209 1771879 inhibitor PD 184352 also *reduced* [PARP] activation and improved LNCaP survival following EGF and IR treatment . Positive_regulation PARP3 MMP28 14766804 1227642 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP3 MMP7 14766804 1227657 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP3 TNF 11835405 911429 Additionally , *induced* caspase-3 and caspase-8 activation and TNF induced [PARP] cleavage were unaffected by the presence or absence of STAT1 . Positive_regulation PARP3 TNF 11907276 923585 Our results indicate that *induces* [PARP] activation leading to ATP depletion and subsequent necrosis . Positive_regulation PARP3 TNF 12829021 1105074 The cell lines overexpressing MnSOD ( 1F2 or 2C6 ) displayed decreased radiation induced , induced , or IL-3 withdrawal *induced* mitochondrial membrane permeability , caspase-3 and [PARP] activation , and apoptosis . Positive_regulation PARP3 TNF 15492857 1321718 As the molecular mechanism involved , we showed Delta-1 stimulation partially suppressed the sequential activation of caspase-8 , caspase-3 , and , [PARP] *induced* by . Positive_regulation PARP3 TNF 19181934 2043859 Pre-exposure of cells to an IKK inhibitor ( PS-1145 ) prevented *induced* caspase-3 and [PARP] cleavage . Positive_regulation PARP3 TNF 20236182 2237975 DEC2 over-expression caused by the transfection of an expression vector reduced the amounts of cleaved [PARP] and caspase-8 *induced* by treatment , whereas DEC1 over-expression increased it . Positive_regulation PARP3 TNFSF10 11964312 932780 While it had no activity alone , ectopic overexpression of Smac/DIABLO or treatment with the N-terminus heptapeptide ( Smac-7 ) or tetrapeptide ( Smac-4 ) of Smac/DIABLO significantly increased Epo B- or *induced* processing and [PARP] cleavage activity of caspase-3 . Positive_regulation PARP3 TNFSF10 17273769 1691738 Fenretinide and cooperatively *activated* caspase-3 , -8 , -10 and -9 and cleavage of Bid and [PARP] , and this activation was also blocked in the presence of DR5/Fc chimeric protein . Positive_regulation PARP3 TNFSF10 20667470 2317068 The pro-survival effect is associated with an increased expression of the inhibitor of apoptosis protein-1 ( c-IAP1 ) , a decrease of *induced* cleavage of [PARP] , procaspase 9 and procaspase 3 , and a decrease of cytochrome C release from the mitochondria . Positive_regulation PARP3 TNFSF10 22982206 2716116 We first found that VA induces a major molecule of ER stress , CCAAT/enhancer binding protein homologous protein ( CHOP ) -dependent DR5 induction and subsequently increases *induced* cleavage of caspases and [PARP] in TRAIL-resistant Hep3B cells . Positive_regulation PARP4 CCND1 20512478 2264108 The G(1)/S phase arrest was accompanied by down regulation of , one of the cyclins required for advance from G ( 1 ) to S. Subsequent apoptosis was *induced* by the gradual activation of caspase-3 and the cleavage of [PARP] . Positive_regulation PARP4 EPHB2 16152590 1517339 Bcl-2 phosphorylation and *activation* of and JNK and caspase 3-dependent cleavage of [PARP] were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation PARP4 FAS 11259186 795753 The MC159 expressing virus blocked *induced* activation of caspase-3 and -8 , degradation of [PARP] , and cleavage of DNA , whereas the parental vaccinia virus did not . Positive_regulation PARP4 FAS 11907276 923557 TNF but not *mediated* [PARP] activation , whereas a PARP inhibitor suppressed TNF induced necrosis and the sensitizing effect of zVAD . Positive_regulation PARP4 FAS 23246487 2736935 Further studies with HCT8 cells showed that knockdown of FAM3B increased the protein levels of membrane bound and Bax , reduced the expression of Bcl-2 , *promoted* the cleavage of caspases-8 , -3 , -9 and [PARP] , and the nuclear translocation of cleaved PARP . Positive_regulation PARP4 FAS 9398401 468988 Ligation of CD40 potentiates *mediated* activation of the cysteine protease CPP32 , cleavage of its death substrate [PARP] , and apoptosis in Ramos-Burkitt lymphoma B cells . Positive_regulation PARP4 IL1B 17404069 1721537 Resveratrol inhibits *induced* stimulation of caspase-3 and cleavage of [PARP] in human articular chondrocytes in vitro . Positive_regulation PARP4 MAP2K6 17295209 1771865 inhibitor PD 184352 also *reduced* [PARP] activation and improved LNCaP survival following EGF and IR treatment . Positive_regulation PARP4 MMP28 14766804 1227598 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP4 MMP7 14766804 1227613 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP4 TNF 11835405 911427 Additionally , *induced* caspase-3 and caspase-8 activation and TNF induced [PARP] cleavage were unaffected by the presence or absence of STAT1 . Positive_regulation PARP4 TNF 11907276 923583 Our results indicate that *induces* [PARP] activation leading to ATP depletion and subsequent necrosis . Positive_regulation PARP4 TNF 12829021 1105070 The cell lines overexpressing MnSOD ( 1F2 or 2C6 ) displayed decreased radiation induced , induced , or IL-3 withdrawal *induced* mitochondrial membrane permeability , caspase-3 and [PARP] activation , and apoptosis . Positive_regulation PARP4 TNF 15492857 1321716 As the molecular mechanism involved , we showed Delta-1 stimulation partially suppressed the sequential activation of caspase-8 , caspase-3 , and , [PARP] *induced* by . Positive_regulation PARP4 TNF 19181934 2043857 Pre-exposure of cells to an IKK inhibitor ( PS-1145 ) prevented *induced* caspase-3 and [PARP] cleavage . Positive_regulation PARP4 TNF 20236182 2237973 DEC2 over-expression caused by the transfection of an expression vector reduced the amounts of cleaved [PARP] and caspase-8 *induced* by treatment , whereas DEC1 over-expression increased it . Positive_regulation PARP4 TNFSF10 11964312 932778 While it had no activity alone , ectopic overexpression of Smac/DIABLO or treatment with the N-terminus heptapeptide ( Smac-7 ) or tetrapeptide ( Smac-4 ) of Smac/DIABLO significantly increased Epo B- or *induced* processing and [PARP] cleavage activity of caspase-3 . Positive_regulation PARP4 TNFSF10 17273769 1691736 Fenretinide and cooperatively *activated* caspase-3 , -8 , -10 and -9 and cleavage of Bid and [PARP] , and this activation was also blocked in the presence of DR5/Fc chimeric protein . Positive_regulation PARP4 TNFSF10 20667470 2317066 The pro-survival effect is associated with an increased expression of the inhibitor of apoptosis protein-1 ( c-IAP1 ) , a decrease of *induced* cleavage of [PARP] , procaspase 9 and procaspase 3 , and a decrease of cytochrome C release from the mitochondria . Positive_regulation PARP4 TNFSF10 22982206 2716114 We first found that VA induces a major molecule of ER stress , CCAAT/enhancer binding protein homologous protein ( CHOP ) -dependent DR5 induction and subsequently increases *induced* cleavage of caspases and [PARP] in TRAIL-resistant Hep3B cells . Positive_regulation PARP6 CCND1 20512478 2264106 The G(1)/S phase arrest was accompanied by down regulation of , one of the cyclins required for advance from G ( 1 ) to S. Subsequent apoptosis was *induced* by the gradual activation of caspase-3 and the cleavage of [PARP] . Positive_regulation PARP6 EPHB2 16152590 1517337 Bcl-2 phosphorylation and *activation* of and JNK and caspase 3-dependent cleavage of [PARP] were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation PARP6 FAS 11259186 795751 The MC159 expressing virus blocked *induced* activation of caspase-3 and -8 , degradation of [PARP] , and cleavage of DNA , whereas the parental vaccinia virus did not . Positive_regulation PARP6 FAS 11907276 923555 TNF but not *mediated* [PARP] activation , whereas a PARP inhibitor suppressed TNF induced necrosis and the sensitizing effect of zVAD . Positive_regulation PARP6 FAS 23246487 2736931 Further studies with HCT8 cells showed that knockdown of FAM3B increased the protein levels of membrane bound and Bax , reduced the expression of Bcl-2 , *promoted* the cleavage of caspases-8 , -3 , -9 and [PARP] , and the nuclear translocation of cleaved PARP . Positive_regulation PARP6 FAS 9398401 468986 Ligation of CD40 potentiates *mediated* activation of the cysteine protease CPP32 , cleavage of its death substrate [PARP] , and apoptosis in Ramos-Burkitt lymphoma B cells . Positive_regulation PARP6 IL1B 17404069 1721535 Resveratrol inhibits *induced* stimulation of caspase-3 and cleavage of [PARP] in human articular chondrocytes in vitro . Positive_regulation PARP6 MAP2K6 17295209 1771851 inhibitor PD 184352 also *reduced* [PARP] activation and improved LNCaP survival following EGF and IR treatment . Positive_regulation PARP6 MMP28 14766804 1227554 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP6 MMP7 14766804 1227569 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP6 TNF 11835405 911425 Additionally , *induced* caspase-3 and caspase-8 activation and TNF induced [PARP] cleavage were unaffected by the presence or absence of STAT1 . Positive_regulation PARP6 TNF 11907276 923581 Our results indicate that *induces* [PARP] activation leading to ATP depletion and subsequent necrosis . Positive_regulation PARP6 TNF 12829021 1105066 The cell lines overexpressing MnSOD ( 1F2 or 2C6 ) displayed decreased radiation induced , induced , or IL-3 withdrawal *induced* mitochondrial membrane permeability , caspase-3 and [PARP] activation , and apoptosis . Positive_regulation PARP6 TNF 15492857 1321714 As the molecular mechanism involved , we showed Delta-1 stimulation partially suppressed the sequential activation of caspase-8 , caspase-3 , and , [PARP] *induced* by . Positive_regulation PARP6 TNF 19181934 2043855 Pre-exposure of cells to an IKK inhibitor ( PS-1145 ) prevented *induced* caspase-3 and [PARP] cleavage . Positive_regulation PARP6 TNF 20236182 2237971 DEC2 over-expression caused by the transfection of an expression vector reduced the amounts of cleaved [PARP] and caspase-8 *induced* by treatment , whereas DEC1 over-expression increased it . Positive_regulation PARP6 TNFSF10 11964312 932776 While it had no activity alone , ectopic overexpression of Smac/DIABLO or treatment with the N-terminus heptapeptide ( Smac-7 ) or tetrapeptide ( Smac-4 ) of Smac/DIABLO significantly increased Epo B- or *induced* processing and [PARP] cleavage activity of caspase-3 . Positive_regulation PARP6 TNFSF10 17273769 1691734 Fenretinide and cooperatively *activated* caspase-3 , -8 , -10 and -9 and cleavage of Bid and [PARP] , and this activation was also blocked in the presence of DR5/Fc chimeric protein . Positive_regulation PARP6 TNFSF10 20667470 2317064 The pro-survival effect is associated with an increased expression of the inhibitor of apoptosis protein-1 ( c-IAP1 ) , a decrease of *induced* cleavage of [PARP] , procaspase 9 and procaspase 3 , and a decrease of cytochrome C release from the mitochondria . Positive_regulation PARP6 TNFSF10 22982206 2716112 We first found that VA induces a major molecule of ER stress , CCAAT/enhancer binding protein homologous protein ( CHOP ) -dependent DR5 induction and subsequently increases *induced* cleavage of caspases and [PARP] in TRAIL-resistant Hep3B cells . Positive_regulation PARP8 CCND1 20512478 2264104 The G(1)/S phase arrest was accompanied by down regulation of , one of the cyclins required for advance from G ( 1 ) to S. Subsequent apoptosis was *induced* by the gradual activation of caspase-3 and the cleavage of [PARP] . Positive_regulation PARP8 EPHB2 16152590 1517335 Bcl-2 phosphorylation and *activation* of and JNK and caspase 3-dependent cleavage of [PARP] were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation PARP8 FAS 11259186 795749 The MC159 expressing virus blocked *induced* activation of caspase-3 and -8 , degradation of [PARP] , and cleavage of DNA , whereas the parental vaccinia virus did not . Positive_regulation PARP8 FAS 11907276 923553 TNF but not *mediated* [PARP] activation , whereas a PARP inhibitor suppressed TNF induced necrosis and the sensitizing effect of zVAD . Positive_regulation PARP8 FAS 23246487 2736927 Further studies with HCT8 cells showed that knockdown of FAM3B increased the protein levels of membrane bound and Bax , reduced the expression of Bcl-2 , *promoted* the cleavage of caspases-8 , -3 , -9 and [PARP] , and the nuclear translocation of cleaved PARP . Positive_regulation PARP8 FAS 9398401 468984 Ligation of CD40 potentiates *mediated* activation of the cysteine protease CPP32 , cleavage of its death substrate [PARP] , and apoptosis in Ramos-Burkitt lymphoma B cells . Positive_regulation PARP8 IL1B 17404069 1721533 Resveratrol inhibits *induced* stimulation of caspase-3 and cleavage of [PARP] in human articular chondrocytes in vitro . Positive_regulation PARP8 MAP2K6 17295209 1771837 inhibitor PD 184352 also *reduced* [PARP] activation and improved LNCaP survival following EGF and IR treatment . Positive_regulation PARP8 MMP28 14766804 1227510 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP8 MMP7 14766804 1227525 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP8 TNF 11835405 911423 Additionally , *induced* caspase-3 and caspase-8 activation and TNF induced [PARP] cleavage were unaffected by the presence or absence of STAT1 . Positive_regulation PARP8 TNF 11907276 923579 Our results indicate that *induces* [PARP] activation leading to ATP depletion and subsequent necrosis . Positive_regulation PARP8 TNF 12829021 1105062 The cell lines overexpressing MnSOD ( 1F2 or 2C6 ) displayed decreased radiation induced , induced , or IL-3 withdrawal *induced* mitochondrial membrane permeability , caspase-3 and [PARP] activation , and apoptosis . Positive_regulation PARP8 TNF 15492857 1321712 As the molecular mechanism involved , we showed Delta-1 stimulation partially suppressed the sequential activation of caspase-8 , caspase-3 , and , [PARP] *induced* by . Positive_regulation PARP8 TNF 19181934 2043853 Pre-exposure of cells to an IKK inhibitor ( PS-1145 ) prevented *induced* caspase-3 and [PARP] cleavage . Positive_regulation PARP8 TNF 20236182 2237969 DEC2 over-expression caused by the transfection of an expression vector reduced the amounts of cleaved [PARP] and caspase-8 *induced* by treatment , whereas DEC1 over-expression increased it . Positive_regulation PARP8 TNFSF10 11964312 932774 While it had no activity alone , ectopic overexpression of Smac/DIABLO or treatment with the N-terminus heptapeptide ( Smac-7 ) or tetrapeptide ( Smac-4 ) of Smac/DIABLO significantly increased Epo B- or *induced* processing and [PARP] cleavage activity of caspase-3 . Positive_regulation PARP8 TNFSF10 17273769 1691732 Fenretinide and cooperatively *activated* caspase-3 , -8 , -10 and -9 and cleavage of Bid and [PARP] , and this activation was also blocked in the presence of DR5/Fc chimeric protein . Positive_regulation PARP8 TNFSF10 20667470 2317062 The pro-survival effect is associated with an increased expression of the inhibitor of apoptosis protein-1 ( c-IAP1 ) , a decrease of *induced* cleavage of [PARP] , procaspase 9 and procaspase 3 , and a decrease of cytochrome C release from the mitochondria . Positive_regulation PARP8 TNFSF10 22982206 2716110 We first found that VA induces a major molecule of ER stress , CCAAT/enhancer binding protein homologous protein ( CHOP ) -dependent DR5 induction and subsequently increases *induced* cleavage of caspases and [PARP] in TRAIL-resistant Hep3B cells . Positive_regulation PARP9 CCND1 20512478 2264101 The G(1)/S phase arrest was accompanied by down regulation of , one of the cyclins required for advance from G ( 1 ) to S. Subsequent apoptosis was *induced* by the gradual activation of caspase-3 and the cleavage of [PARP] . Positive_regulation PARP9 EPHB2 16152590 1517332 Bcl-2 phosphorylation and *activation* of and JNK and caspase 3-dependent cleavage of [PARP] were observed in MDA-MB-435 cells treated with CB694 . Positive_regulation PARP9 FAS 11259186 795746 The MC159 expressing virus blocked *induced* activation of caspase-3 and -8 , degradation of [PARP] , and cleavage of DNA , whereas the parental vaccinia virus did not . Positive_regulation PARP9 FAS 11907276 923550 TNF but not *mediated* [PARP] activation , whereas a PARP inhibitor suppressed TNF induced necrosis and the sensitizing effect of zVAD . Positive_regulation PARP9 FAS 23246487 2736921 Further studies with HCT8 cells showed that knockdown of FAM3B increased the protein levels of membrane bound and Bax , reduced the expression of Bcl-2 , *promoted* the cleavage of caspases-8 , -3 , -9 and [PARP] , and the nuclear translocation of cleaved PARP . Positive_regulation PARP9 FAS 9398401 468981 Ligation of CD40 potentiates mediated *activation* of the cysteine protease CPP32 , cleavage of its death substrate [PARP] , and apoptosis in Ramos-Burkitt lymphoma B cells . Positive_regulation PARP9 IL1B 17404069 1721530 Resveratrol inhibits *induced* stimulation of caspase-3 and cleavage of [PARP] in human articular chondrocytes in vitro . Positive_regulation PARP9 MAP2K6 17295209 1771816 inhibitor PD 184352 also *reduced* [PARP] activation and improved LNCaP survival following EGF and IR treatment . Positive_regulation PARP9 MMP28 14766804 1227444 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP9 MMP7 14766804 1227459 The cleavage of [PARP] by MMP-2 was also *blocked* by inhibitors . Positive_regulation PARP9 TNF 11835405 911420 Additionally , *induced* caspase-3 and caspase-8 activation and TNF induced [PARP] cleavage were unaffected by the presence or absence of STAT1 . Positive_regulation PARP9 TNF 11907276 923576 Our results indicate that *induces* [PARP] activation leading to ATP depletion and subsequent necrosis . Positive_regulation PARP9 TNF 12829021 1105056 The cell lines overexpressing MnSOD ( 1F2 or 2C6 ) displayed decreased radiation induced , induced , or IL-3 withdrawal *induced* mitochondrial membrane permeability , caspase-3 and [PARP] activation , and apoptosis . Positive_regulation PARP9 TNF 15492857 1321709 As the molecular mechanism involved , we showed Delta-1 stimulation partially suppressed the sequential activation of caspase-8 , caspase-3 , and , [PARP] *induced* by . Positive_regulation PARP9 TNF 19181934 2043850 Pre-exposure of cells to an IKK inhibitor ( PS-1145 ) prevented *induced* caspase-3 and [PARP] cleavage . Positive_regulation PARP9 TNF 20236182 2237966 DEC2 over-expression caused by the transfection of an expression vector reduced the amounts of cleaved [PARP] and caspase-8 *induced* by treatment , whereas DEC1 over-expression increased it . Positive_regulation PARP9 TNFSF10 11964312 932771 While it had no activity alone , ectopic overexpression of Smac/DIABLO or treatment with the N-terminus heptapeptide ( Smac-7 ) or tetrapeptide ( Smac-4 ) of Smac/DIABLO significantly increased Epo B- or *induced* processing and [PARP] cleavage activity of caspase-3 . Positive_regulation PARP9 TNFSF10 17273769 1691729 Fenretinide and cooperatively *activated* caspase-3 , -8 , -10 and -9 and cleavage of Bid and [PARP] , and this activation was also blocked in the presence of DR5/Fc chimeric protein . Positive_regulation PARP9 TNFSF10 20667470 2317059 The pro-survival effect is associated with an increased expression of the inhibitor of apoptosis protein-1 ( c-IAP1 ) , a decrease of *induced* cleavage of [PARP] , procaspase 9 and procaspase 3 , and a decrease of cytochrome C release from the mitochondria . Positive_regulation PARP9 TNFSF10 22982206 2716107 We first found that VA induces a major molecule of ER stress , CCAAT/enhancer binding protein homologous protein ( CHOP ) -dependent DR5 induction and subsequently increases *induced* cleavage of caspases and [PARP] in TRAIL-resistant Hep3B cells . Positive_regulation PARVA ANKRD1 15872073 1426121 Overexpression of the PINCH-1 binding of ILK but not that of a PINCH-1 binding defective mutant form of the ankyrin domain effectively *inhibited* the formation of the [PINCH-1-ILK-alpha-parvin] complex . Positive_regulation PAWR F2R 12716374 1083718 These studies provide evidence that , in human platelets , both Galphaq and PLC-beta2 play a major role in *responses* to and [PAR4] activation , and that PLC-beta2 is required for the sustained Ca2+ rise upon thrombin activation . Positive_regulation PAWR F2R 20128804 2235799 The contractile effect of thrombin was abolished by either a protease inhibitor or a proteinase activated receptor 1 ( PAR(1) ) antagonist , while it was mimicked by *activating* peptide ( PAR(1)AP ) , but not [PAR(4)AP] . Positive_regulation PAWR FAS 11585763 866263 [Par-4] drives trafficking and *activation* of and Fasl to induce prostate cancer cell apoptosis and tumor regression . Positive_regulation PAX2 MAP2K6 20392803 2307361 Stretch stimulated [Pax2] expression was *suppressed* by a p38 inhibitor , SB203580 , or a inhibitor , PD98059 . Positive_regulation PAX3 MSX1 15691759 1371431 *induces* [Pax3] and ZicR1 cell autonomously , in turn , Pax3 combined with ZicR1 activates Slug in a WNT dependent manner . Positive_regulation PBK EPHB2 15265705 1275447 It is suggested that PI3K and *mediated* the activation of [SPK] and would be involved in the HGF induced migration of endothelial cells . Positive_regulation PC PLAT 10574983 569391 Additionally , *triggers* activation of [pro-PCB] in blood plasma in a reaction that is stimulated by a neutralizing antibody versus alpha(2)-antiplasmin . Positive_regulation PC TNF 20638727 2322037 Further in-silico analysis showed that [PCB-153] most likely *acted* through the receptor , leading to oxidative stress involving metallothionein gene families , and causing apoptosis mainly by the Fas receptor signaling pathway . Positive_regulation PCBD1 ARSA 18335236 1912218 Here , we provide evidences that ASA also behaves as an agent inducing programmed cell death (PCD) in cell cultures of the model plant Arabidopsis thaliana , in a similar way than the well established PCD inducing agent H ( 2 ) O ( 2 ) , although the *induction* of [PCD] by requires much lower inducer concentrations . Positive_regulation PCBD1 FAS 10537175 563110 We investigated the possibility that FAP-1 might be involved in protection against *mediated* [PCD] in human thyrocytes . Positive_regulation PCBD1 FAS 10537175 563111 In addition , in the presence of a suboptimal concentration of CHX , the Ac-SLV tripeptide yielded a strong , synergistic increase in *mediated* [PCD] as compared to thyrocytes treated with control tripeptide . Positive_regulation PCBD1 FAS 10537175 563112 These results implicate FAP-1 as a regulator of *induced* [PCD] in thyrocytes . Positive_regulation PCBD1 FAS 10579724 569902 In the presence of neurotrophic factors , exogenous activators such as soluble FasL or anti-Fas antibodies *triggered* [PCD] of 40-50 % of purified motoneurons over the following 3-5 d ; Positive_regulation PCBD1 FAS 10807785 692338 ( CD95 ) *triggers* [programmed cell death (PCD)] and is involved in immune response control and cell mediated cytotoxicity . Positive_regulation PCBD1 FAS 12855571 1149811 In B lymphocytes , *induction* of apoptosis or [programmed cell death (PCD)] by ( CD95/APO-1 ) is suppressed by the triggering of CD40 . Positive_regulation PCBD1 FAS 17153599 1661701 In leukemic Jurkat cells Tau-Cl ( > 200 microM ) triggers mitochondrial , p53 independent apoptosis and amplifies [PCD] *induced* by treatment . Positive_regulation PCBD1 MUC16 22847250 2671347 Different [pHs] ( 5.8 , 6.8 and 7.4 ) in the apical medium , the *presence* or absence of ( 3.0 % w/v ) in the donor site and the presence or absence of bovine serum albumin ( 4.0 % v/v ) in the receptor chamber were the evaluated conditions . Positive_regulation PCBD1 TNF 11009421 735897 These cells are also more susceptible than control cells to undergo *mediated* [PCD] . Positive_regulation PCBD1 TNF 11090464 754662 Several lines of evidence are provided to show that progesterone regulates luteal cell survival : 1 ) CL and LECs express progesterone receptor mRNA , 2 ) physiological levels of the steroid abolished *induced* [PCD] of LECs , and 3 ) progesterone producing cells are protected from PCD . Positive_regulation PCBD1 TNF 11090464 754663 In conclusion , this study suggests that *induced* [PCD] during structural luteolysis is mediated by TNFRI , primarily affects endothelial cells , and that the decline in progesterone , preceding structural luteolysis , is a prerequisite for the initiation of apoptosis in endothelial cells . Positive_regulation PCBD1 TNF 16083851 1442917 Here , we demonstrate that stable transfection of a cDNA encompassing the C-terminal apoptosis inhibitory domain ( AID ) of FE65-like protein 1 into mouse L929 fibrosarcoma cells protects from caspase independent as well as from apoptotic [PCD] *induced* by . Positive_regulation PCBD1 TNF 16267788 1502318 This latter activity of NF-kappaB antagonizes [programmed cell death (PCD)] *induced* by the proinflammatory cytokine and plays an important role in immunity , lymphopoiesis , osteogenesis , tumorigenesis and radio- and chemoresistance in cancer . Positive_regulation PCBD1 TNF 16267788 1502321 Notably , NF-kappaB also blunts accumulation of reactive oxygen species ( ROS ) , which themselves are pivotal elements for *induction* of [PCD] by , and this suppression of ROS formation mediates an additional protective activity recently ascribed to NF-kappaB . Positive_regulation PCBD1 TNF 16456579 1547992 Activation of NF-kappaB antagonizes [programmed cell death (PCD)] *induced* by and several other triggers . Positive_regulation PCBD1 TNF 17026999 1647905 In concert with the enhanced resistance of AC-overexpressing cells against caspase independent [PCD] *induced* by , our results suggest that ceramide acts as a common mediator of caspase independent PCD caused by death receptors such as mTRAIL-R2 and TNF-R55 . Positive_regulation PCBD1 TNF 17403902 1742058 Twist-1 is an evolutionarily conserved target of NF-kappaB , blocks [PCD] *induced* by chemotherapeutic drugs and in NF-kappaB-deficient cells , and is essential to counter this PCD in cancer cells . Positive_regulation PCBD1 TNF 19347278 2057476 NF-kappaB also counters [programmed cell death (PCD)] *induced* by the proinflammatory cytokine , and this activity of NF-kappaB is crucial for organismal physiology , chronic inflammation , and tumorigenesis . Positive_regulation PCBD1 TNF 8262257 239162 The present paper focuses on some specific aspects of [PCD] *induced* by the cytokine . Positive_regulation PCBD1 TNFSF10 10438545 634873 Despite the expression of TRAIL receptors death receptor 4 and death receptor 5 , purified could not *induce* [programmed cell death (PCD)] in any of the thyroid follicular cells examined . Positive_regulation PCBD1 TNFSF10 10438545 634874 This suggested that despite the presence of a labile inhibitor of the TRAIL pathway , could *mediate* [PCD] under appropriate conditions . Positive_regulation PCBD1 TNFSF10 17026999 1647904 Cells overexpressing acid ceramidase (AC) , an enzyme that metabolizes the sphingolipid ceramide , show enhanced survival from *induced* caspase independent [PCD] but not from apoptosis , implicating a function of ceramide as a key mediator in caspase independent PCD ( but not apoptosis ) induced by mTRAIL-R2 . Positive_regulation PCBD2 TNF 8473346 216240 Stimulation of the cells with , phorbol 12-myristate 13-acetate , lipopolysaccharide , or interleukin-1 *increased* mRNA levels for [PHS II] , and this change correlated well with increased prostacyclin biosynthesis . Positive_regulation PCDH19 CTCF 22854024 2660632 is *required* for neural development and stochastic expression of clustered [Pcdh] genes in neurons . Positive_regulation PCDH19 RET 20616001 2296905 In particular , we find that the receptor tyrosine kinase binds to Pcdhs in differentiated neuroblastoma cells and is *required* for stabilization and differentiation induced phosphorylation of [Pcdh] proteins . Positive_regulation PCDH8 CTCF 22854024 2660637 is *required* for neural development and stochastic expression of clustered [Pcdh] genes in neurons . Positive_regulation PCDH8 RET 20616001 2296910 In particular , we find that the receptor tyrosine kinase binds to Pcdhs in differentiated neuroblastoma cells and is *required* for stabilization and differentiation induced phosphorylation of [Pcdh] proteins . Positive_regulation PCDHA1 PCDH19 15347688 1333775 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA1 PCDH8 15347688 1333780 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA10 PCDH19 15347688 1333786 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA10 PCDH8 15347688 1333791 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA11 PCDH19 15347688 1333797 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA11 PCDH8 15347688 1333802 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA12 PCDH19 15347688 1333808 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA12 PCDH8 15347688 1333813 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA13 PCDH19 15347688 1333819 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA13 PCDH8 15347688 1333824 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA14 PCDH19 15347688 1333764 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA14 PCDH8 15347688 1333769 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA2 PCDH19 15347688 1333830 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA2 PCDH8 15347688 1333835 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA3 PCDH19 15347688 1333841 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA3 PCDH8 15347688 1333846 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA4 PCDH19 15347688 1333852 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA4 PCDH8 15347688 1333857 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA5 PCDH19 15347688 1333863 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA5 PCDH8 15347688 1333868 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA6 PCDH19 15347688 1333874 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA6 PCDH8 15347688 1333879 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA7 PCDH19 15347688 1333885 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA7 PCDH8 15347688 1333890 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA8 PCDH19 15347688 1333896 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA8 PCDH8 15347688 1333901 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA9 PCDH19 15347688 1333907 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCDHA9 PCDH8 15347688 1333912 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Positive_regulation PCGF2 ID1 20697353 2335480 In this study , we examined the effect of Id1 on polycomb group ( PcG ) proteins , which are crucial epigenetic gene silencers , and found that *regulated* the expression of [Mel-18] and Bmi-1 , both of which belong to polycomb repressive complex 1 . Positive_regulation PCK1 CA12 6427227 37987 Studies of [phosphoenolpyruvate carboxylase] in the *presence* and absence of in vitro confirm the validity of the method . Positive_regulation PCK1 FAS 2195292 136365 [Phosphoenolpyruvate carboxykinase] ( PEPCK ) activity increased after 2 weeks on a LP diet ( +35 % , day 21 ) and activity *increased* only during the first week on the diet ( +100 % , day 7 ) . Positive_regulation PCK1 FOXO1 11467835 840754 The insulin responsive H4IIEC3 rat hepatoma cell line ( H4 cells ) was used in order to determine the *role* of the transcription factor in the regulation of [phosphoenolpyruvate carboxykinase] ( PEPCK ) and glucose-6-phosphatase (G6Pase) . Positive_regulation PCK2 FAS 2195292 136366 [Phosphoenolpyruvate carboxykinase] ( PEPCK ) activity increased after 2 weeks on a LP diet ( +35 % , day 21 ) and activity *increased* only during the first week on the diet ( +100 % , day 7 ) . Positive_regulation PCK2 FOXO1 11467835 840755 The insulin responsive H4IIEC3 rat hepatoma cell line ( H4 cells ) was used in order to determine the *role* of the transcription factor in the regulation of [phosphoenolpyruvate carboxykinase] ( PEPCK ) and glucose-6-phosphatase (G6Pase) . Positive_regulation PCNA ANGPT1 21704119 2465571 In cultured EAFs from prepubertal rats treated with diethylstilbestrol (DES) , *increased* [PCNA] and decreased apoptosis while ANGPT2 reversed these effects . Positive_regulation PCNA CAPN8 12569370 1057312 Treatment of ZR75 cultures with calcium+A23187 recapitulated the formation of the *induced* LMW forms of [cyclin] E. Altered calcium homeostasis and/or inability of the endogenous calpain inhibitor to control the activity of high levels of the calpain small subunit may contribute to increased calpain activity in breast tumors , causing abundant levels of LMW cyclin E . Positive_regulation PCNA CAPN8 17566644 1763121 In this neurotoxic model , Western blot studies revealed that activity increase was *followed* by changes in [cyclin dependent kinase 5 (cdk5)] and its activator p25 . Positive_regulation PCNA CAPN8 20506302 2362899 Using selective pharmacological tools , we showed that enhanced intracellular calcium lead to [cyclin dependent kinase 5 (cdk5)] *activation* , by proteolysis of p35 to p25 , as well as glycogen synthase kinase 3ß (GSK3ß) activation , by its phosphorylation at tyrosine 216 . Positive_regulation PCNA CCND1 10086334 599638 Expression of exogenous , SV40 large T antigen or CCG1/TAF(II)250 *increased* [cyclin] A expression at 39.5 degrees C. Coexpression of HPV16 E7 and adenovirus E1b19K , which blocks apoptosis , rescued the proliferation of tsBN462 cells at 38.5 degrees C . Positive_regulation PCNA CCND1 10440924 635522 This increased kinase activity was accompanied by an elevated level of protein and *increased* G1 [cyclin/cdk] complex formation . Positive_regulation PCNA CCND1 10516294 652327 Analysis of the different cell cycle regulatory elements in this model revealed that apoptosis is preceded by an *increase* in the level of [cyclin] E protein , with elevated nuclear levels of and with enhanced activity of the cyclin D1- and E- associated kinases . Positive_regulation PCNA CCND1 10766840 684537 binds and *regulates* the activity of [cyclin dependent kinases (CDKs)] 4 and 6 . Positive_regulation PCNA CCND1 11114718 759177 The kinase activities of cyclin D/CDK4 , 6 and cyclin E/CDK2 complexes were only slightly elevated , consistent with the findings that coordinate increases in p21 , and cyclin E *resulted* in an increase in [cyclin/CDK/p21] complexes . Positive_regulation PCNA CCND1 12401786 1025521 Our data also demonstrate that ectopic overexpression of either cyclin is sufficient to induce mitogen independent growth in human T98G and Rat-1 cells , although the effects of *require* downstream activation of [cyclin] E-CDK2 activity . Positive_regulation PCNA CCND1 15033176 1223354 IGF-I enhanced FGF-2 induction of , *activation* of G ( 1 ) [cyclin-cyclin] dependent kinase (cdk) complexes , and hyperphosphorylation of retinoblastoma protein ( pRb ) . Positive_regulation PCNA CCND1 16023250 1441605 Exposure to RS is able to block cell cycle progression after and [PCNA] *induction* , but prior to S phase . Positive_regulation PCNA CCND1 17070615 1675179 In normal cells , complexes with and *activates* [cyclin dependent kinases (CDK)] and acts as a transcriptional regulator . Positive_regulation PCNA CCND1 20801098 2324494 inhibits p300 dependent RUNX3 acetylation and negatively *regulates* [cyclin dependent kinase (cdk)] inhibitor p21 expression . Positive_regulation PCNA CCND1 7479977 331971 Ectopic expression of *triggers* premature activation of the [cyclin] A promoter by E2F , and this effect is blocked by the tumor suppressor protein p16INK4 . Positive_regulation PCNA CCND1 9169494 432870 overexpression *resulted* in a concomitant increase in CDK4 levels in the adult myocardium , as well as modest increases in [proliferating cell nuclear antigen] and CDK2 levels . Positive_regulation PCNA CCND1 9236224 445607 We have shown previously ( ) that NGF *induces* the expression of the p21 WAF1/CIP1/Sdi1 ( p21 ) cyclin dependent kinase (Cdk) inhibitor protein and the G1 phase [cyclin] , . Positive_regulation PCNA CCND1 9244353 446264 We demonstrate that both and CDK4 functionally depend on active Myc to exert their potential as oncogenes and vice versa that the transforming ability of Myc *requires* functional [cyclin] D/CDK complexes . Positive_regulation PCNA CCND1 9281369 451452 Cyclin E- and A-associated histone H1 kinase activity and retinoblastoma protein associated kinase activity also increased , but [cyclin] B kinase activity was not *enhanced* by IGF-1 . Positive_regulation PCNA CDKN1C 15294951 1279032 Most notably , increased levels *resulted* in marked inhibition of both cyclin E- and [cyclin] A-associated cdk2 kinase activities and a decrease in cyclin A amounts . Positive_regulation PCNA EDN2 18973526 2086086 The *roles* of the receptors A and B ( ET ( A ) and ET ( B ) ) in CsA enhanced expression of [PCNA] and iNOS were examined in cultured human gingival fibroblasts pretreated with receptor antagonists , by immunocytochemistry and RT-PCR , respectively . Positive_regulation PCNA EPHB2 17893107 1823884 In stimulated MC , inhibition of *reduced* cyclin dependent kinase 2 (CDK2) phosphorylation , CDK2 activity and [cyclin] E/A expression , whereas downregulation of CDK inhibitor p27 ( Kip1 ) expression was inhibited . Positive_regulation PCNA EPHB2 19139116 2025560 However , only an inhibitor *prevented* [D-cyclin] IRES activity in resistant `` low-AKT '' myeloma cells . Positive_regulation PCNA FAS 12955077 1137676 Although Rb is inactivated by phosphorylation by cyclins D and E and their associated kinases during cell cycle progression , we find that Rb is inactivated upon apoptotic *stimulation* by through the mediation of p38 kinase , independent of cyclins and [cyclin dependent kinases (cdks)] . Positive_regulation PCNA FUT4 17556010 1773842 We found that overexpression promoted cell proliferation and *increased* the expression of [proliferating cell nuclear antigen] that correlated with Lewis Y augmentation . Positive_regulation PCNA ID1 12949053 1158039 In the PLC/PRF/5 HCC cell line study , ectopic expression *resulted* in proliferation of HCC cells and an increased percentage of S phase cells and [PCNA] expression . Positive_regulation PCNA IFI27 10896783 711677 Evaluation of the kinase activity of cyclin-Cdk complexes showed that RA increases ( Kip1 ) expression in CH27 cells *leading* to markedly reduced [cyclin] A/Cdk2 kinase activity and slightly reduced cyclin E/Cdk2 kinase activity , with no effect on cyclin D/Cdk4 and cyclin D/Cdk6 activities . Positive_regulation PCNA IFI27 15367678 1294786 Adhesion of epithelial cells to the ECM failed to efficiently induce degradation of , to induce cdk2 activity , or to *induce* Myc and [cyclin] A synthesis ; Positive_regulation PCNA IFI27 21312237 2398705 WIN 55,212-2 also upregulated phospho-ERK1/2 , *induced* and Cip1/WAF1/p21 expression , decreased cyclin D1 and [cyclin] E expression , decreased Cdk 2 , Cdk 4 , and Cdk 6 expression levels , and decreased phospho-Rb and E2F-1 expression . Positive_regulation PCNA PLAT 20724593 2323798 In the murine obstruction model , deficiency *reduced* renal GSK3ß phosphorylation and induction of [PCNA] and FSP-1 . Positive_regulation PCNA SPHK1 17114809 1677160 Tumor necrosis factor-alpha stimulated cell proliferation is mediated through *dependent* Akt activation and [cyclin] D expression . Positive_regulation PCNA SYNM 22113341 2658126 also *resulted* in a repression of cyclin or [cyclin-like] transcripts . Positive_regulation PCNA TNF 16195372 1462898 Wild-type and TNFR1-specific mutein trigger tubular cell apoptosis whereas wild-type TNF and TNFR2-specific mutein *induce* tubular cells to express [proliferating cell nuclear antigen] . Positive_regulation PCNA TNF 17114809 1677185 Furthermore , [cyclin] D expression was *increased* by in a SphK- and Akt dependent manner . Positive_regulation PCNA TNF 17114809 1677202 We conclude that SphK dependent Akt activation plays a significant role in *induced* [cyclin] D expression and cell proliferation . Positive_regulation PCNA TNF 17273796 1691780 We found that curcumin inhibited the expression of TNF-alpha induced IL-1beta , IL-6 , and TNF-alpha , but not IL-8 , in TNF-alpha treated HaCaT cells as well as the *induced* [cyclin] E expression . Positive_regulation PCNA TNF 21811927 2462727 Furthermore , treatment with OD 78 decreased *induced* levels of cyclin E , cyclin D1 , CDK2 , [proliferating cell nuclear antigen] , and phosphorylated retinoblastoma protein , but not the CDK4 expression level . Positive_regulation PCNA TNF 23035855 2716432 In addition , the effects of total flavonoids on inflammatory molecule expression of cells were tested by immunohistochemistry staining , showing that *induced* expression of [PCNA] , NF-?B p65 , ICAM-1 , and VCAM-1 in VSMCs was dose-dependently suppressed by total flavonoids . Positive_regulation PCNP TNF 23141169 2763643 Lipopolysaccharide , , and IL-1ß significantly *stimulated* [NT-pCNP] production in a dose and time dependent manner ; Positive_regulation PCSK9 ANXA2 24808179 2950609 In this study , we investigated the effect of silencing the expression of AnxA2 and PCSK9 in HepG2 and Huh7 cells to better define the *role* of in [PCSK9] regulation . Positive_regulation PCSK9 ANXA2 24808179 2950612 Overall , our data revealed a plausible new *role* of in the reduction of [PCSK9] protein levels via a translational mechanism . Positive_regulation PCSK9 APAF1 20462491 2257656 Apaf-1 coassembles with cytochrome c to form the , which then binds and *activates* [procaspase-9 (pc-9)] . Positive_regulation PCSK9 APOB 19917273 2197784 Thus , in the *presence* of high levels , [wild-type-PCSK9] , which has twice the binding affinity of R46L-PCSK9 to bind to the LDLR , may not be significantly more potent in degrading the LDLR than R46L-PCSK9 . Positive_regulation PCSK9 APOB 21847580 2521802 However , *induced* HUVEC apoptosis and [PCSK9] expression , but not LOX-1 expression , were significantly reduced by PCSK9 siRNA . Positive_regulation PCSK9 CA2 8306412 249051 The endonuclease activity of VP-16 treated N231 , but not [PC-9] , cells *required* both and Mg2+ for full activity . Positive_regulation PCSK9 CETP 23307117 2725942 In this review , we discuss these promising therapies , which include [PCSK9] *inhibitors* , apolipoprotein B antisense oligonucleotides , microsomal transfer protein inhibitors , thyroid mimetics , and inhibitors . Positive_regulation PCSK9 CHRD 23105118 2707058 The is *required* for the activity of [PCSK9] , but the mechanism behind this remains obscure . Positive_regulation PCSK9 CYCS 20462491 2257655 Apaf-1 coassembles with cytochrome c to form the , which then binds and *activates* [procaspase-9 (pc-9)] . Positive_regulation PCSK9 EEF1A2 18298956 1878911 Of functional relevance , coadministration of CDCA counteracted the *induced* [PCSK9] expression , leading to a potentiation of LDL receptor activity . Positive_regulation PCSK9 EEF1A2 20525997 2301546 Since that initial observation , at least two other groups have reported *induced* [PCSK9] increases . Positive_regulation PCSK9 EGF 24103783 2863566 Characterization of the *role* of of low density lipoprotein receptor in [PCSK9] binding . Positive_regulation PCSK9 EGF 24103783 2863571 Here , we further characterized the *role* of in binding of [PCSK9] to the LDLR . Positive_regulation PCSK9 EGF 24103783 2863577 Thus , our findings reveal that of the LDLR is *critical* for [PCSK9] binding at the cell surface ( neutral pH ) and at the acidic endosomal environment ( pH 6.0 ) , but different determinants contribute to efficient PCSK9 binding in different pH environments . Positive_regulation PCSK9 FURIN 21147780 2384595 In agreement with a key *role* of in regulating [PCSK9] activity in vivo , we observed an overall 26 % drop in the LDL receptor protein levels of Fur-hKO livers , likely due to the compound effects of a 35 % increase in PCSK9 mRNA levels and the loss of PCSK9 cleavage , suggesting a higher activity of PCSK9 in these mice . Positive_regulation PCSK9 FURIN 21147780 2384597 We conclude that in hepatocytes *regulates* [PCSK9] mRNA levels and is the key in vivo inactivating protease of circulating PCSK9 . Positive_regulation PCSK9 HGF 22722827 2644099 The *stimulation* of [PC-9] with caused an increase in the topo I protein level via the activation of MET . Positive_regulation PCSK9 HGF 23327866 2733649 *stimulated* Met phosphorylation in the [PC-9] and H292 cells . Positive_regulation PCSK9 HNF1A 22288532 2580233 In addition to SREBP2 , ( hepatic nuclear factor 1a ) positively *regulates* [PCSK9] gene transcription in hepatic cells through a binding site located 28 bp upstream from SRE . Positive_regulation PCSK9 HNF1A 22426206 2577573 [Pcsk9] is *regulated* by the transcription factor , and our further detailed analyses suggest that increased mTORC1 activity leads to activation of PKCd , reduced activity of HNF4a and HNF1a , decreased PCSK9 expression , and ultimately increased hepatic LDLR protein levels , which result in decreased circulating LDL levels . Positive_regulation PCSK9 IL1B 10623436 658033 The HLA-class I antigen expression of [PC-9] was *augmented* by either TNF-alpha or . Positive_regulation PCSK9 INS 16407292 1527446 Moreover , *up-regulated* hepatic [PCSK9] expression in vivo during a hyperinsulinemic-euglycemic clamp in mice . Positive_regulation PCSK9 INS 16407292 1527447 Adenoviral mediated overexpression of a dominant or negative form of SREBP-1c confirmed the implication of this transcription factor in *mediated* stimulation of [PCSK9] expression . Positive_regulation PCSK9 LDLR 24103783 2863567 Characterization of the *role* of EGF-A of in [PCSK9] binding . Positive_regulation PCSK9 LDLR 24144304 2889460 *promoted* autocatalytic cleavage of [pro-PCSK9] . Positive_regulation PCSK9 LDLR 24144304 2889462 The findings of the present study indicate that the binding of to pro-PCSK9 in the ER *promotes* autocatalytic cleavage of [PCSK9] , and autocatalytically cleaved PCSK9 acts as a chaperone to promote the exit of WT-ED-LDLR from the ER . Positive_regulation PCSK9 MCOLN1 8306412 249050 The endonuclease activity of VP-16 treated N231 , but not [PC-9] , cells *required* both Ca2+ and for full activity . Positive_regulation PCSK9 MYLIP 24675665 2935056 Interestingly , hepatic overexpression markedly *increased* plasma [PCSK9] levels . Positive_regulation PCSK9 MYLIP 24675665 2935057 In wild-type mice , but not in LDLR-deficient mice , *enhanced* hepatic [PCSK9] expression , with activation of sterol regulatory element binding protein 2 and subsequently increased expression of its target genes . Positive_regulation PCSK9 MYLIP 24675665 2935058 A vicious cycle in LDLR degradation might be generated by [PCSK9] *induced* by hepatic overexpression via dual mechanisms : sterol regulatory element binding protein 2/LDLR . Positive_regulation PCSK9 PTGS2 23065687 2915625 We sought to determine whether ( prostaglandin G/H synthase and cyclooxygenase ) ( PTGS2 ) ( aka COX2 ) , whose expression is also frequently increased in NSCLC , differentially *regulates* [PCSK] expression and activity between normal ( NHBE ) and NSCLC epithelial cells ( NCI-H292 , NCI-H441 , A549 ) . Positive_regulation PCSK9 SORT1 24506872 2914237 Furthermore , circulating PCSK9 and sortilin were positively correlated in a human cohort of healthy individuals , suggesting that is *involved* in [PCSK9] secretion in humans . Positive_regulation PCSK9 SREBF1 17921436 1849151 In summary , it is suggested that the expression of PCSK9 is regulated by sterol at the transcriptional level in HepG2 cells and that both and SREBP-2 can transcriptionally *activate* [PCSK9] via SRE in its proximal promoter region in vitro . Positive_regulation PCSK9 SREBF2 17921436 1849150 Expression of nuclear forms of sterol-regulatory element binding protein-1 ( SREBP-1 ) and dramatically *increased* the promoter activity of [PCSK9] . Positive_regulation PCSK9 SREBF2 17921436 1849152 In summary , it is suggested that the expression of PCSK9 is regulated by sterol at the transcriptional level in HepG2 cells and that both SREBP-1 and can transcriptionally *activate* [PCSK9] via SRE in its proximal promoter region in vitro . Positive_regulation PCSK9 SREBF2 17921436 1849153 However , in vivo , it is suggested that the sterol dependent regulation of [PCSK9] is *mediated* predominantly by . Positive_regulation PCSK9 SREBF2 19687008 2144378 Finally , we show that a coordinate modest reduction of HNF1alpha and nuclear by BBR *led* to a strong suppression of [PCSK9] transcription through these two critical regulatory sequences . Positive_regulation PCSK9 SREBF2 22288532 2580237 Mutation of this motif lowers the basal promoter activity and abolishes the sterol mediated repression as well as the *induced* activation of the [PCSK9] promoter . Positive_regulation PCSK9 TNF 10623436 658032 The HLA-class I antigen expression of [PC-9] was *augmented* by either or IL-1beta . Positive_regulation PDAP1 TNF 10982776 732009 We examined whether *induction* of [PAP I] expression was mediated by NF-kappaB or MAP kinases by using specific inhibitors of both pathways . Positive_regulation PDB1 TNF 15979550 1424665 However , neutralization of TNF-alpha by addition of anti-TNF-alpha antibodies did not prevent the suppression of mitogenesis , induction of apoptosis , or *activation* of gene expression by [PDB] . Positive_regulation PDC FOXO1 22315317 2580515 The *role* of and PPAR transcription factors in diet mediated inhibition of [PDC] activation and carbohydrate oxidation during exercise in humans and the role of pharmacological activation of PDC in overriding these changes . Positive_regulation PDC TLR7 16889610 1613930 Higher doses of prednisolone were needed to induce apoptosis in *stimulated* [PDC] . Positive_regulation PDC TLR7 18287072 1872596 Thus , PDC-TREM is responsible for IFN-alpha production , whereas signals are *essential* for [PDC-TREM] expression . Positive_regulation PDC TLR7 20067543 2177860 Finally , in *stimulated* [PDC] , PGE ( 2 ) and TGF-beta reduce the CCR7 : CXCR4 ratio , suggesting that PDC are impaired in their ability to migrate to tumour draining lymph nodes but are retained in stromal cell derived factor 1 (SDF-1) expressing tissues . Positive_regulation PDC TLR7 23131038 2745287 However , in both study populations , the stimulation in comparison to TLR9 stimulation *induced* higher expression of [PDC] surface activation and maturation markers and significantly ( p < 0.05 ) decreased the expression of BDCA-2 , a negative regulator of interferon . Positive_regulation PDC TLR7 23968562 2855736 Surprisingly , mTOR-inhibition enhanced the capacity of *activated* [PDC] to stimulate naive and memory T helper cell proliferation , which was caused by rapamycin induced up-regulation of CD80 expression on PDC . Positive_regulation PDC TLR7 23968562 2855737 Finally , rapamycin treatment of *activated* [PDC] enhanced their capacity to induce CD4 ( + ) forkhead box protein 3 (FoxP3) ( + ) regulatory T cells , but did not affect the generation of suppressive CD8 ( + ) CD38 ( + ) lymphocyte activation gene (LAG)-3 ( + ) Treg . Positive_regulation PDC TLR7 23968562 2855743 In general , rapamycin inhibits innate and adaptive immune functions of *stimulated* human [PDC] , but enhances the ability of TLR-7 stimulated PDC to stimulate CD4 ( + ) T cell proliferation and induce CD4 ( + ) FoxP3 ( + ) regulatory T cell generation . Positive_regulation PDCD1 CAPN8 10825507 696628 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Positive_regulation PDCD1 CAPN8 18496573 1965482 ICP10PK inhibits *dependent* release of apoptosis inducing factor and [programmed cell death] in response to the toxin MPP+ . Positive_regulation PDCD1 CAPN8 20224428 2272663 Because beta3 integrin contributes to cardioprotective signaling , these studies indicate that the loss of specific integrin function could be a key mechanism for *mediated* [programmed cell death] of cardiomyocytes in PO myocardium . Positive_regulation PDCD1 CLU 22358960 178191 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Positive_regulation PDCD1 EPHB2 18713014 1974670 signaling *leads* to stimulus-specific changes in gene expression , alterations in cell metabolism or induction of [programmed cell death] ( apoptosis ) , and thus controls cell differentiation and proliferation . Positive_regulation PDCD1 FAS 10352248 617134 Restimulation of Ag receptors on peripheral T lymphocytes induces tyrosine phosphorylation based signaling cascades that evoke Fas ligand expression and induction of *mediated* [programmed cell death] . Positive_regulation PDCD1 FAS 10679090 668762 These results provide evidence that *mediated* [programmed cell death] plays a significant role in the pathogenesis of autoimmune diabetes . Positive_regulation PDCD1 FAS 10722700 677206 Activation of either tumor necrosis factor receptor 1 or *induces* a low level of [programmed cell death] in LNCaP human prostate cancer cells . Positive_regulation PDCD1 FAS 10726692 677722 Ceramides ( known stimuli of apoptosis downstream from the CD95-receptor complex ) also were used to test whether apoptosis would be induced in neuroblastoma cell cultures resistant to *mediated* [programmed cell death] . Positive_regulation PDCD1 FAS 11061245 746370 ( CD95 ) *triggers* [programmed cell death] and is involved in shutting off the immune response . Positive_regulation PDCD1 FAS 11164911 782697 The cellular caspase-inhibitory protein FLIP has been recently identified as a potent regulator of T lymphocyte susceptibility to *mediated* [programmed cell death] ( apoptosis ) . Positive_regulation PDCD1 FAS 11246866 793286 ( CD95 ) *triggers* [programmed cell death] and is involved in cell mediated cytotoxicity and in shutting off the immune response . Positive_regulation PDCD1 FAS 11342432 812720 Surprisingly , it was found that clonogenic progenitors were protected from gammaIFN plus *induced* [programmed cell death] when Lin ( + ) cells were removed from cultured splenocytes . Positive_regulation PDCD1 FAS 11385298 821645 ( CD95 ) and Fas ligand ( FasL/CD95L ) are *involved* in [programmed cell death] and the regulation of host immune responses . Positive_regulation PDCD1 FAS 11483955 844632 Here we have used a screen for proteins that interact physically with the cytoplasmic domain of the type II TGF-beta receptor to isolate the gene encoding Daxx - a protein associated with the Fas receptor that mediates activation of Jun amino-terminal kinase (JNK) and [programmed cell death] *induced* by . Positive_regulation PDCD1 FAS 1385299 200732 Binding of anti-APO-1 antibody to the *induces* [programmed cell death] ( apoptosis ) . Positive_regulation PDCD1 FAS 14977887 1227992 In fact , G1-overexpressing cells appeared resistant to both cytotoxic drug induced and *dependent* [programmed cell death] , and this resistance implicated mitochondrial apoptotic genes . Positive_regulation PDCD1 FAS 15879137 1406051 Heat killed A. phagocytophilum caused some similar initial alterations in neutrophil gene expression and function , which included delaying normal PMN apoptosis and blocking *induced* [programmed cell death] . Positive_regulation PDCD1 FAS 1689786 128394 Binding of to cells expressing APO-1 *results* in [programmed cell death] , apoptosis , the most common form of death in eukaryotic cells . Positive_regulation PDCD1 FAS 17605793 1774722 Molecular and biochemical assessment of these mutant Fas ligand proteins were carried out by expressing the mutant FasL cDNA in mammalian cells and analysis its effects on *mediated* [programmed cell death] . Positive_regulation PDCD1 FAS 22553782 2590581 However , PI3-K activation is crucial upon the BCR driven anti-apoptotic effect , while p38 MAPK mediated inactivation of caspases seems to play essential role in TLR9 mediated protection against *induced* [programmed cell death] . Positive_regulation PDCD1 FAS 7530337 291605 ( CD95 ) /FasL interactions *required* for [programmed cell death] after T-cell activation . Positive_regulation PDCD1 FAS 7896458 299838 In contrast to malignant cell lines , which express low levels of bax-alpha , non-malignant epithelial cell lines displaying high amounts of bax-alpha were highly sensitive to *induction* of [programmed cell death] by both serum starvation and ( CD95 ) triggering . Positive_regulation PDCD1 FAS 8647190 363429 While in most situations ligation *activates* [programmed cell death] , on resting T lymphocytes it can co-stimulate proliferation with the T cell receptor (TCR)/CD3 complex . Positive_regulation PDCD1 FAS 8670891 375078 Cathepsin D protease mediates [programmed cell death] *induced* by interferon-gamma , and TNF-alpha . Positive_regulation PDCD1 FAS 8758891 377819 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Positive_regulation PDCD1 FAS 8824295 385034 Genetic and pharmacological inhibition of Ras or Rac 1 and Rac 2 stimulation blocks Fas induced apoptosis , pointing to an important function of a Ras and Rac protein regulated signaling pathway in *mediated* [programmed cell death] . Positive_regulation PDCD1 FAS 8943716 400142 *induced* [programmed cell death] is mediated by a Ras regulated O2- synthesis . Positive_regulation PDCD1 FAS 8943716 400150 Likewise , the antioxidants N-acetyl-cysteine and N-t-butyl-phenylnitrone abolished Fas induced cell death , pointing to an important role for Ras triggered ROI synthesis in *mediated* [programmed cell death] . Positive_regulation PDCD1 FAS 8967952 402395 [Programmed cell death] ( apoptosis ) *mediated* by the cytokine receptor is critical for the removal of autoreactive T cells , the mechanism of immune privilege , and for maintenance of immune-system homeostasis . Positive_regulation PDCD1 FAS 9049148 416917 Reactive oxygen species ( ROS ) appear to be involved in *induced* [programmed cell death] . Positive_regulation PDCD1 FAS 9049787 416988 In contrast , rechallenge of previously stimulated lymphocytes with anti-CD3 monoclonal antibody triggered apoptosis in a larger proportion of T cells from cord blood as compared to peripheral blood , whereas the number of T cells undergoing *induced* [programmed cell death] were lower in cord blood compared to peripheral blood . Positive_regulation PDCD1 FAS 9064994 406204 The ( APO-1/Fas ) receptor *mediates* [programmed cell death] in apoptosis sensitive cells upon oligomerization either by CD95 antibody or by its natural ligand , CD95 ligand (CD95 L) . Positive_regulation PDCD1 FAS 9126929 426591 The interaction of ( CD95 ) , a member of the tumor necrosis factor receptor (TNFR) family , and its ligand ( FasL ) *triggers* [programmed cell death] ( apoptosis ) and is involved in the regulation of immune responses . Positive_regulation PDCD1 FAS 9177220 434102 In addition to providing costimulatory signals for cell proliferation , ligation of both TNFR1 and can *result* in [programmed cell death] or apoptosis . Positive_regulation PDCD1 FAS 9207149 440673 The n-type K+ channel ( n-K+ , Kv1.3 ) in lymphocytes has been recently implicated in the regulation of *induced* [programmed cell death] . Positive_regulation PDCD1 FAS 9207415 440818 CD40 and *induce* [programmed cell death] in the human myeloma cell line XG2 . Positive_regulation PDCD1 FAS 9208846 440996 ( CD95 ) ligation *activates* [programmed cell death] , a cellular process that plays an important role in the maturation of the host immune response . Positive_regulation PDCD1 FAS 9350288 460825 The mutation is leaky , allowing for low levels of the APO-1/Fas ( CD95 ) receptor and partial activity of ligand *mediated* [programmed cell death] in this strain . Positive_regulation PDCD1 FAS 9454753 484348 ) *triggers* [programmed cell death] after activation by its ligand and because incubation of human ECFCs with IFNgamma produces apoptosis , we have investigated the expression and function of Fas and Fas ligand (FasL) in highly purified human ECFCs before and after incubation with IFNgamma in vitro . Positive_regulation PDCD1 FAS 9490596 489553 [Programmed cell death] ( apoptosis ) *mediated* by ( CD95 ) , a 45-kD surface protein belonging to the tumor necrosis factor receptor family , is important in the resolution of all inflammatory immune responses . Positive_regulation PDCD1 FAS 9806545 544812 We also found that Pml is essential for *induction* of [programmed cell death] by , tumour necrosis factor alpha (TNF) , ceramide and type I and II interferons ( IFNs ) . Positive_regulation PDCD1 JAG1 16027528 1435883 Evaluation of biochemical and morphological features suggested that the major form of [programmed cell death] *induced* by 115 and EFDAC was autophagy . Positive_regulation PDCD1 MAP2K6 18713014 1974676 signaling *leads* to stimulus-specific changes in gene expression , alterations in cell metabolism or induction of [programmed cell death] ( apoptosis ) , and thus controls cell differentiation and proliferation . Positive_regulation PDCD1 TGM2 11697888 877631 activity is *involved* in polyamine induced [programmed cell death] . Positive_regulation PDCD1 TGM2 24778637 2937151 Senescence and [programmed cell death] in plants : polyamine action *mediated* by . Positive_regulation PDCD1 TNF 10657935 664293 Tumor necrosis factor (TNF) receptor ( TNFR ) -associated factors 1 and 2 ( TRAF1 and TRAF2 ) and inhibitor of apoptosis proteins cIAP1 ( MIHB ) and cIAP2 ( MIHC ) were recently identified as proteins that associate with the TNF-alpha receptors TNFRI ( p55 ) and TNFRII ( p75 ) and inhibit *induced* [programmed cell death] or apoptosis . Positive_regulation PDCD1 TNF 10858960 704747 These proteins are also known to interfere with [programmed cell death] *induced* by and Fas ligand . Positive_regulation PDCD1 TNF 11153078 759050 Since ceramide is an important regulatory molecule of [programmed cell death] *induced* by , we examined whether nef could alter TNF-alpha induced apoptosis in the U251MG human astrocytoma cell line . Positive_regulation PDCD1 TNF 12048203 968538 The activation of AKT2 inhibits UV- and TNF alpha induced c-Jun N-terminal kinase (JNK) and p38 activities that have been shown to be required for stress- and *induced* [programmed cell death] . Positive_regulation PDCD1 TNF 12048203 968546 Furthermore , phosphatidylinositol 3-kinase inhibitor or dominant negative AKT2 significantly enhances UV- and TNF alpha induced apoptosis , whereas expression of constitutively active AKT2 inhibits [programmed cell death] in *response* to UV and -induced apoptosis by inhibition of stress kinases and provide the first evidence that AKT inhibits stress kinase JNK through activation of the NF kappa B pathway . Positive_regulation PDCD1 TNF 12093867 960426 Fas and the *regulate* the [programmed cell death] of lymphocytes . Positive_regulation PDCD1 TNF 12446776 1017910 The proinflammatory cytokine *regulates* immune responses , inflammation , and [programmed cell death] ( apoptosis ) . Positive_regulation PDCD1 TNF 12933798 1151442 Zoledronate sensitizes endothelial cells to *induced* [programmed cell death] : evidence for the suppression of sustained activation of focal adhesion kinase and protein kinase B/Akt . Positive_regulation PDCD1 TNF 12933798 1151450 Taken together these data demonstrate that zoledronate sensitizes endothelial cells to *induced* , caspase independent [programmed cell death] and point to the FAK-PKB/Akt pathway as a novel zoledronate target . Positive_regulation PDCD1 TNF 14989423 1034259 IL-1 and TNFalpha share several biological properties but the salient difference is that receptor signaling *induces* [programmed cell death] whereas IL-1 receptor signaling does not . Positive_regulation PDCD1 TNF 15225801 1268420 Activation of p38 MAP kinase was shown to have both pro- and anti-apoptotic actions in *induced* [programmed cell death] depending on cell context . Positive_regulation PDCD1 TNF 15621052 1358403 *induces* [programmed cell death] and contributes to cardiac ischemia/reperfusion injury . Positive_regulation PDCD1 TNF 16077199 1442298 Apparently , cycloheximide sensitized cells to *induced* [programmed cell death] . Positive_regulation PDCD1 TNF 16083851 1442910 The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase independent [programmed cell death] *mediated* by . Positive_regulation PDCD1 TNF 18064605 1867942 We found that deoxycholyltaurine (DCT) markedly attenuated both unstimulated and *stimulated* [programmed cell death] in colon cancer cells by a phosphatidylinositol 3-kinase (PI3K) dependent mechanism . Positive_regulation PDCD1 TNF 18851874 2000874 Although both L153R and C417R impaired TLR and TNF-alpha induced NF-kappaB activation , L153R also increased *induced* [programmed cell death] with decreased A20 expression . Positive_regulation PDCD1 TNF 19706490 2144763 Expression of HO-1 suppresses the pro-oxidant effects of free heme , preventing it from sensitizing hepatocytes to undergo *mediated* [programmed cell death] by apoptosis . Positive_regulation PDCD1 TNF 20683023 2299012 Heterogeneity of radiation- and *induced* [programmed cell death] in carcinoma , sarcoma and lymphoma cell lines . Positive_regulation PDCD1 TNF 20705491 2312796 A20 is a ubiquitin modifying enzyme that restricts NF-kappaB signals and protects cells against *induced* [programmed cell death] . Positive_regulation PDCD1 TNF 20832854 2325317 It is thus suggested that the co-immobilized TNF-a plus IFN-? promotes the activation of some unknown key markers in response to IFN-? , and the binding of the co-immobilized plus IFN-? with some other TNF-a receptors *results* in enhanced [programmed cell death] in HeLa cells . Positive_regulation PDCD1 TNF 7593233 334614 Interferon-gamma and suppress both early and late stages of hematopoiesis and *induce* [programmed cell death] . Positive_regulation PDCD1 TNF 7600193 311510 The *induction* of accelerated thymic [programmed cell death] during polymicrobial sepsis : control by corticosteroids but not . Positive_regulation PDCD1 TNF 8166195 254828 *Induction* of [programmed cell death] ( apoptosis ) by was quantitated by means of a deoxyribonucleic acid fragmentation assay . Positive_regulation PDCD1 TNF 8627883 356108 Furthermore , by using a nuclease digestion assay , we demonstrated that *activated* a Ca++/Mg++ dependent endonuclease responsible for [programmed cell death] or apoptosis . Positive_regulation PDCD1 TNF 8657285 367003 Ceramide is an important regulatory participant of [programmed cell death] ( apoptosis ) *induced* by and Fas ligand , members of the TNF superfamily . Positive_regulation PDCD1 TNF 8670891 375077 Cathepsin D protease mediates [programmed cell death] *induced* by interferon-gamma , Fas/APO-1 and . Positive_regulation PDCD1 TNF 8670891 375099 Pepstatin A , an inhibitor of cathepsin D , suppressed cell death in these systems and interfered with the *induced* [programmed cell death] of U937 cells as well . Positive_regulation PDCD1 TNF 8758891 377818 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Positive_regulation PDCD1 TNF 9565035 500888 In adenovirus infected cells , [programmed cell death] ( apoptosis ) *induced* by the cytokine is inhibited by several adenovirus encoded proteins . Positive_regulation PDCD1 TNF 9602717 478286 Furthermore , *stimulates* [programmed cell death] ( apoptosis ) in luteal cells kept under culture conditions . Positive_regulation PDCD1 TNF 9806545 544811 We also found that Pml is essential for *induction* of [programmed cell death] by Fas , , ceramide and type I and II interferons ( IFNs ) . Positive_regulation PDCD1 TNFSF10 10960444 726372 Recombinant *induced* extensive [programmed cell death] in cholangiocarcinoma cell lines lacking decoy receptor expression . Positive_regulation PDCD1 TNFSF10 12398939 1008993 can selectively *induce* [programmed cell death] in transformed cells , although its wide tissue distribution suggests potential physiological roles . Positive_regulation PDCD1 TNFSF10 16251995 1525662 Using adenovirus ( Ad ) -mediated gene transfer , we overexpressed the proapoptotic molecules p53 , procaspase 3 , Bax , and to *induce* therapeutic [programmed cell death] of residual lens cells to prevent PCO . Positive_regulation PDCD1 TNFSF10 16651415 1557585 We propose that MNDA has a role regulating programmed cell death in myeloid progenitor cells , and that its down-regulation in MDS is related to granulocyte-macrophage progenitor cell sensitivity to *induced* [programmed cell death] . Positive_regulation PDCD1 TNFSF10 16934748 1608857 In conclusion , alternative splicing might be involved in functional fine tuning of *induced* [programmed cell death] . Positive_regulation PDCD1 TNFSF10 17487744 1739302 Thus , the effect of bexarotene on *mediated* [programmed cell death] involved proximal events of the extrinsic pathway ; Positive_regulation PDCD1 TNFSF10 19196465 2079378 Here , we hypothesise that the susceptibility of RASFs to receptor mediated apoptosis depends on the proliferation status of these cells and therefore analysed the cell cycle dependency of FasL- and *induced* [programmed cell death] of RASFs in vitro . Positive_regulation PDCD1 TNFSF10 21711324 2494350 The accumulation of apoptotic cell debris has been hypothesized to induce this autoimmune inflammation , and may *trigger* this [programmed cell death] . Positive_regulation PDCD1 TNFSF10 23792015 2824244 The accumulation of apoptotic cell debris has been hypothesized to induce the autoimmune inflammation in SLE , and may *trigger* this [programmed cell death] . Positive_regulation PDCD10 CAPN8 10825507 696642 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Positive_regulation PDCD10 CAPN8 18496573 1965497 ICP10PK inhibits *dependent* release of apoptosis inducing factor and [programmed cell death] in response to the toxin MPP+ . Positive_regulation PDCD10 CAPN8 20224428 2272677 Because beta3 integrin contributes to cardioprotective signaling , these studies indicate that the loss of specific integrin function could be a key mechanism for *mediated* [programmed cell death] of cardiomyocytes in PO myocardium . Positive_regulation PDCD10 CLU 22358960 178192 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Positive_regulation PDCD10 EPHB2 18713014 1974678 signaling *leads* to stimulus-specific changes in gene expression , alterations in cell metabolism or induction of [programmed cell death] ( apoptosis ) , and thus controls cell differentiation and proliferation . Positive_regulation PDCD10 FAS 10352248 617135 Restimulation of Ag receptors on peripheral T lymphocytes induces tyrosine phosphorylation based signaling cascades that evoke Fas ligand expression and induction of *mediated* [programmed cell death] . Positive_regulation PDCD10 FAS 10679090 668764 These results provide evidence that *mediated* [programmed cell death] plays a significant role in the pathogenesis of autoimmune diabetes . Positive_regulation PDCD10 FAS 10722700 677208 Activation of either tumor necrosis factor receptor 1 or *induces* a low level of [programmed cell death] in LNCaP human prostate cancer cells . Positive_regulation PDCD10 FAS 10726692 677723 Ceramides ( known stimuli of apoptosis downstream from the CD95-receptor complex ) also were used to test whether apoptosis would be induced in neuroblastoma cell cultures resistant to *mediated* [programmed cell death] . Positive_regulation PDCD10 FAS 11061245 746371 ( CD95 ) *triggers* [programmed cell death] and is involved in shutting off the immune response . Positive_regulation PDCD10 FAS 11164911 782698 The cellular caspase-inhibitory protein FLIP has been recently identified as a potent regulator of T lymphocyte susceptibility to *mediated* [programmed cell death] ( apoptosis ) . Positive_regulation PDCD10 FAS 11246866 793287 ( CD95 ) *triggers* [programmed cell death] and is involved in cell mediated cytotoxicity and in shutting off the immune response . Positive_regulation PDCD10 FAS 11342432 812721 Surprisingly , it was found that clonogenic progenitors were protected from gammaIFN plus *induced* [programmed cell death] when Lin ( + ) cells were removed from cultured splenocytes . Positive_regulation PDCD10 FAS 11385298 821647 ( CD95 ) and Fas ligand ( FasL/CD95L ) are *involved* in [programmed cell death] and the regulation of host immune responses . Positive_regulation PDCD10 FAS 11483955 844633 Here we have used a screen for proteins that interact physically with the cytoplasmic domain of the type II TGF-beta receptor to isolate the gene encoding Daxx - a protein associated with the Fas receptor that mediates activation of Jun amino-terminal kinase (JNK) and [programmed cell death] *induced* by . Positive_regulation PDCD10 FAS 1385299 200733 Binding of anti-APO-1 antibody to the *induces* [programmed cell death] ( apoptosis ) . Positive_regulation PDCD10 FAS 14977887 1227993 In fact , G1-overexpressing cells appeared resistant to both cytotoxic drug induced and *dependent* [programmed cell death] , and this resistance implicated mitochondrial apoptotic genes . Positive_regulation PDCD10 FAS 15879137 1406052 Heat killed A. phagocytophilum caused some similar initial alterations in neutrophil gene expression and function , which included delaying normal PMN apoptosis and blocking *induced* [programmed cell death] . Positive_regulation PDCD10 FAS 1689786 128395 Binding of to cells expressing APO-1 *results* in [programmed cell death] , apoptosis , the most common form of death in eukaryotic cells . Positive_regulation PDCD10 FAS 17605793 1774723 Molecular and biochemical assessment of these mutant Fas ligand proteins were carried out by expressing the mutant FasL cDNA in mammalian cells and analysis its effects on *mediated* [programmed cell death] . Positive_regulation PDCD10 FAS 22553782 2590582 However , PI3-K activation is crucial upon the BCR driven anti-apoptotic effect , while p38 MAPK mediated inactivation of caspases seems to play essential role in TLR9 mediated protection against *induced* [programmed cell death] . Positive_regulation PDCD10 FAS 7530337 291607 ( CD95 ) /FasL interactions *required* for [programmed cell death] after T-cell activation . Positive_regulation PDCD10 FAS 7896458 299839 In contrast to malignant cell lines , which express low levels of bax-alpha , non-malignant epithelial cell lines displaying high amounts of bax-alpha were highly sensitive to *induction* of [programmed cell death] by both serum starvation and ( CD95 ) triggering . Positive_regulation PDCD10 FAS 8647190 363430 While in most situations ligation *activates* [programmed cell death] , on resting T lymphocytes it can co-stimulate proliferation with the T cell receptor (TCR)/CD3 complex . Positive_regulation PDCD10 FAS 8670891 375081 Cathepsin D protease mediates [programmed cell death] *induced* by interferon-gamma , and TNF-alpha . Positive_regulation PDCD10 FAS 8758891 377821 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Positive_regulation PDCD10 FAS 8824295 385035 Genetic and pharmacological inhibition of Ras or Rac 1 and Rac 2 stimulation blocks Fas induced apoptosis , pointing to an important function of a Ras and Rac protein regulated signaling pathway in *mediated* [programmed cell death] . Positive_regulation PDCD10 FAS 8943716 400143 *induced* [programmed cell death] is mediated by a Ras regulated O2- synthesis . Positive_regulation PDCD10 FAS 8943716 400151 Likewise , the antioxidants N-acetyl-cysteine and N-t-butyl-phenylnitrone abolished Fas induced cell death , pointing to an important role for Ras triggered ROI synthesis in *mediated* [programmed cell death] . Positive_regulation PDCD10 FAS 8967952 402396 [Programmed cell death] ( apoptosis ) *mediated* by the cytokine receptor is critical for the removal of autoreactive T cells , the mechanism of immune privilege , and for maintenance of immune-system homeostasis . Positive_regulation PDCD10 FAS 9049148 416918 Reactive oxygen species ( ROS ) appear to be involved in *induced* [programmed cell death] . Positive_regulation PDCD10 FAS 9049787 416989 In contrast , rechallenge of previously stimulated lymphocytes with anti-CD3 monoclonal antibody triggered apoptosis in a larger proportion of T cells from cord blood as compared to peripheral blood , whereas the number of T cells undergoing *induced* [programmed cell death] were lower in cord blood compared to peripheral blood . Positive_regulation PDCD10 FAS 9064994 406205 The ( APO-1/Fas ) receptor *mediates* [programmed cell death] in apoptosis sensitive cells upon oligomerization either by CD95 antibody or by its natural ligand , CD95 ligand (CD95 L) . Positive_regulation PDCD10 FAS 9126929 426592 The interaction of ( CD95 ) , a member of the tumor necrosis factor receptor (TNFR) family , and its ligand ( FasL ) *triggers* [programmed cell death] ( apoptosis ) and is involved in the regulation of immune responses . Positive_regulation PDCD10 FAS 9177220 434104 In addition to providing costimulatory signals for cell proliferation , ligation of both TNFR1 and can *result* in [programmed cell death] or apoptosis . Positive_regulation PDCD10 FAS 9207149 440674 The n-type K+ channel ( n-K+ , Kv1.3 ) in lymphocytes has been recently implicated in the regulation of *induced* [programmed cell death] . Positive_regulation PDCD10 FAS 9207415 440820 CD40 and *induce* [programmed cell death] in the human myeloma cell line XG2 . Positive_regulation PDCD10 FAS 9208846 440997 ( CD95 ) ligation *activates* [programmed cell death] , a cellular process that plays an important role in the maturation of the host immune response . Positive_regulation PDCD10 FAS 9350288 460827 The mutation is leaky , allowing for low levels of the APO-1/Fas ( CD95 ) receptor and partial activity of ligand *mediated* [programmed cell death] in this strain . Positive_regulation PDCD10 FAS 9454753 484349 ) *triggers* [programmed cell death] after activation by its ligand and because incubation of human ECFCs with IFNgamma produces apoptosis , we have investigated the expression and function of Fas and Fas ligand (FasL) in highly purified human ECFCs before and after incubation with IFNgamma in vitro . Positive_regulation PDCD10 FAS 9490596 489554 [Programmed cell death] ( apoptosis ) *mediated* by ( CD95 ) , a 45-kD surface protein belonging to the tumor necrosis factor receptor family , is important in the resolution of all inflammatory immune responses . Positive_regulation PDCD10 FAS 9806545 544815 We also found that Pml is essential for *induction* of [programmed cell death] by , tumour necrosis factor alpha (TNF) , ceramide and type I and II interferons ( IFNs ) . Positive_regulation PDCD10 JAG1 16027528 1435884 Evaluation of biochemical and morphological features suggested that the major form of [programmed cell death] *induced* by 115 and EFDAC was autophagy . Positive_regulation PDCD10 MAP2K6 18713014 1974684 signaling *leads* to stimulus-specific changes in gene expression , alterations in cell metabolism or induction of [programmed cell death] ( apoptosis ) , and thus controls cell differentiation and proliferation . Positive_regulation PDCD10 TGM2 11697888 877638 activity is *involved* in polyamine induced [programmed cell death] . Positive_regulation PDCD10 TGM2 24778637 2937158 Senescence and [programmed cell death] in plants : polyamine action *mediated* by . Positive_regulation PDCD10 TNF 10657935 664294 Tumor necrosis factor (TNF) receptor ( TNFR ) -associated factors 1 and 2 ( TRAF1 and TRAF2 ) and inhibitor of apoptosis proteins cIAP1 ( MIHB ) and cIAP2 ( MIHC ) were recently identified as proteins that associate with the TNF-alpha receptors TNFRI ( p55 ) and TNFRII ( p75 ) and inhibit *induced* [programmed cell death] or apoptosis . Positive_regulation PDCD10 TNF 10858960 704749 These proteins are also known to interfere with [programmed cell death] *induced* by and Fas ligand . Positive_regulation PDCD10 TNF 11153078 759051 Since ceramide is an important regulatory molecule of [programmed cell death] *induced* by , we examined whether nef could alter TNF-alpha induced apoptosis in the U251MG human astrocytoma cell line . Positive_regulation PDCD10 TNF 12048203 968539 The activation of AKT2 inhibits UV- and TNF alpha induced c-Jun N-terminal kinase (JNK) and p38 activities that have been shown to be required for stress- and *induced* [programmed cell death] . Positive_regulation PDCD10 TNF 12048203 968547 Furthermore , phosphatidylinositol 3-kinase inhibitor or dominant negative AKT2 significantly enhances UV- and TNF alpha induced apoptosis , whereas expression of constitutively active AKT2 inhibits [programmed cell death] in *response* to UV and -induced apoptosis by inhibition of stress kinases and provide the first evidence that AKT inhibits stress kinase JNK through activation of the NF kappa B pathway . Positive_regulation PDCD10 TNF 12093867 960427 Fas and the *regulate* the [programmed cell death] of lymphocytes . Positive_regulation PDCD10 TNF 12446776 1017911 The proinflammatory cytokine *regulates* immune responses , inflammation , and [programmed cell death] ( apoptosis ) . Positive_regulation PDCD10 TNF 12933798 1151443 Zoledronate sensitizes endothelial cells to *induced* [programmed cell death] : evidence for the suppression of sustained activation of focal adhesion kinase and protein kinase B/Akt . Positive_regulation PDCD10 TNF 12933798 1151451 Taken together these data demonstrate that zoledronate sensitizes endothelial cells to *induced* , caspase independent [programmed cell death] and point to the FAK-PKB/Akt pathway as a novel zoledronate target . Positive_regulation PDCD10 TNF 14989423 1034260 IL-1 and TNFalpha share several biological properties but the salient difference is that receptor signaling *induces* [programmed cell death] whereas IL-1 receptor signaling does not . Positive_regulation PDCD10 TNF 15225801 1268421 Activation of p38 MAP kinase was shown to have both pro- and anti-apoptotic actions in *induced* [programmed cell death] depending on cell context . Positive_regulation PDCD10 TNF 15621052 1358404 *induces* [programmed cell death] and contributes to cardiac ischemia/reperfusion injury . Positive_regulation PDCD10 TNF 16077199 1442299 Apparently , cycloheximide sensitized cells to *induced* [programmed cell death] . Positive_regulation PDCD10 TNF 16083851 1442911 The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase independent [programmed cell death] *mediated* by . Positive_regulation PDCD10 TNF 18064605 1867943 We found that deoxycholyltaurine (DCT) markedly attenuated both unstimulated and *stimulated* [programmed cell death] in colon cancer cells by a phosphatidylinositol 3-kinase (PI3K) dependent mechanism . Positive_regulation PDCD10 TNF 18851874 2000875 Although both L153R and C417R impaired TLR and TNF-alpha induced NF-kappaB activation , L153R also increased *induced* [programmed cell death] with decreased A20 expression . Positive_regulation PDCD10 TNF 19706490 2144764 Expression of HO-1 suppresses the pro-oxidant effects of free heme , preventing it from sensitizing hepatocytes to undergo *mediated* [programmed cell death] by apoptosis . Positive_regulation PDCD10 TNF 20683023 2299013 Heterogeneity of radiation- and *induced* [programmed cell death] in carcinoma , sarcoma and lymphoma cell lines . Positive_regulation PDCD10 TNF 20705491 2312797 A20 is a ubiquitin modifying enzyme that restricts NF-kappaB signals and protects cells against *induced* [programmed cell death] . Positive_regulation PDCD10 TNF 20832854 2325318 It is thus suggested that the co-immobilized TNF-a plus IFN-? promotes the activation of some unknown key markers in response to IFN-? , and the binding of the co-immobilized plus IFN-? with some other TNF-a receptors *results* in enhanced [programmed cell death] in HeLa cells . Positive_regulation PDCD10 TNF 7593233 334616 Interferon-gamma and suppress both early and late stages of hematopoiesis and *induce* [programmed cell death] . Positive_regulation PDCD10 TNF 7600193 311511 The *induction* of accelerated thymic [programmed cell death] during polymicrobial sepsis : control by corticosteroids but not . Positive_regulation PDCD10 TNF 8166195 254829 *Induction* of [programmed cell death] ( apoptosis ) by was quantitated by means of a deoxyribonucleic acid fragmentation assay . Positive_regulation PDCD10 TNF 8627883 356109 Furthermore , by using a nuclease digestion assay , we demonstrated that *activated* a Ca++/Mg++ dependent endonuclease responsible for [programmed cell death] or apoptosis . Positive_regulation PDCD10 TNF 8657285 367005 Ceramide is an important regulatory participant of [programmed cell death] ( apoptosis ) *induced* by and Fas ligand , members of the TNF superfamily . Positive_regulation PDCD10 TNF 8670891 375080 Cathepsin D protease mediates [programmed cell death] *induced* by interferon-gamma , Fas/APO-1 and . Positive_regulation PDCD10 TNF 8670891 375100 Pepstatin A , an inhibitor of cathepsin D , suppressed cell death in these systems and interfered with the *induced* [programmed cell death] of U937 cells as well . Positive_regulation PDCD10 TNF 8758891 377820 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Positive_regulation PDCD10 TNF 9565035 500889 In adenovirus infected cells , [programmed cell death] ( apoptosis ) *induced* by the cytokine is inhibited by several adenovirus encoded proteins . Positive_regulation PDCD10 TNF 9602717 478287 Furthermore , *stimulates* [programmed cell death] ( apoptosis ) in luteal cells kept under culture conditions . Positive_regulation PDCD10 TNF 9806545 544814 We also found that Pml is essential for *induction* of [programmed cell death] by Fas , , ceramide and type I and II interferons ( IFNs ) . Positive_regulation PDCD10 TNFSF10 10960444 726373 Recombinant *induced* extensive [programmed cell death] in cholangiocarcinoma cell lines lacking decoy receptor expression . Positive_regulation PDCD10 TNFSF10 12398939 1008994 can selectively *induce* [programmed cell death] in transformed cells , although its wide tissue distribution suggests potential physiological roles . Positive_regulation PDCD10 TNFSF10 16251995 1525664 Using adenovirus ( Ad ) -mediated gene transfer , we overexpressed the proapoptotic molecules p53 , procaspase 3 , Bax , and to *induce* therapeutic [programmed cell death] of residual lens cells to prevent PCO . Positive_regulation PDCD10 TNFSF10 16651415 1557586 We propose that MNDA has a role regulating programmed cell death in myeloid progenitor cells , and that its down-regulation in MDS is related to granulocyte-macrophage progenitor cell sensitivity to *induced* [programmed cell death] . Positive_regulation PDCD10 TNFSF10 16934748 1608858 In conclusion , alternative splicing might be involved in functional fine tuning of *induced* [programmed cell death] . Positive_regulation PDCD10 TNFSF10 17487744 1739303 Thus , the effect of bexarotene on *mediated* [programmed cell death] involved proximal events of the extrinsic pathway ; Positive_regulation PDCD10 TNFSF10 19196465 2079379 Here , we hypothesise that the susceptibility of RASFs to receptor mediated apoptosis depends on the proliferation status of these cells and therefore analysed the cell cycle dependency of FasL- and *induced* [programmed cell death] of RASFs in vitro . Positive_regulation PDCD10 TNFSF10 21711324 2494351 The accumulation of apoptotic cell debris has been hypothesized to induce this autoimmune inflammation , and may *trigger* this [programmed cell death] . Positive_regulation PDCD10 TNFSF10 23792015 2824245 The accumulation of apoptotic cell debris has been hypothesized to induce the autoimmune inflammation in SLE , and may *trigger* this [programmed cell death] . Positive_regulation PDCD11 CAPN8 10825507 696614 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Positive_regulation PDCD11 CAPN8 18496573 1965467 ICP10PK inhibits *dependent* release of apoptosis inducing factor and [programmed cell death] in response to the toxin MPP+ . Positive_regulation PDCD11 CAPN8 20224428 2272649 Because beta3 integrin contributes to cardioprotective signaling , these studies indicate that the loss of specific integrin function could be a key mechanism for *mediated* [programmed cell death] of cardiomyocytes in PO myocardium . Positive_regulation PDCD11 CLU 22358960 178190 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Positive_regulation PDCD11 EPHB2 18713014 1974662 signaling *leads* to stimulus-specific changes in gene expression , alterations in cell metabolism or induction of [programmed cell death] ( apoptosis ) , and thus controls cell differentiation and proliferation . Positive_regulation PDCD11 FAS 10352248 617133 Restimulation of Ag receptors on peripheral T lymphocytes induces tyrosine phosphorylation based signaling cascades that evoke Fas ligand expression and induction of *mediated* [programmed cell death] . Positive_regulation PDCD11 FAS 10679090 668760 These results provide evidence that *mediated* [programmed cell death] plays a significant role in the pathogenesis of autoimmune diabetes . Positive_regulation PDCD11 FAS 10722700 677204 Activation of either tumor necrosis factor receptor 1 or *induces* a low level of [programmed cell death] in LNCaP human prostate cancer cells . Positive_regulation PDCD11 FAS 10726692 677721 Ceramides ( known stimuli of apoptosis downstream from the CD95-receptor complex ) also were used to test whether apoptosis would be induced in neuroblastoma cell cultures resistant to *mediated* [programmed cell death] . Positive_regulation PDCD11 FAS 11061245 746369 ( CD95 ) *triggers* [programmed cell death] and is involved in shutting off the immune response . Positive_regulation PDCD11 FAS 11164911 782696 The cellular caspase-inhibitory protein FLIP has been recently identified as a potent regulator of T lymphocyte susceptibility to *mediated* [programmed cell death] ( apoptosis ) . Positive_regulation PDCD11 FAS 11246866 793285 ( CD95 ) *triggers* [programmed cell death] and is involved in cell mediated cytotoxicity and in shutting off the immune response . Positive_regulation PDCD11 FAS 11342432 812719 Surprisingly , it was found that clonogenic progenitors were protected from gammaIFN plus *induced* [programmed cell death] when Lin ( + ) cells were removed from cultured splenocytes . Positive_regulation PDCD11 FAS 11385298 821643 ( CD95 ) and Fas ligand ( FasL/CD95L ) are *involved* in [programmed cell death] and the regulation of host immune responses . Positive_regulation PDCD11 FAS 11483955 844630 Here we have used a screen for proteins that interact physically with the cytoplasmic domain of the type II TGF-beta receptor to isolate the gene encoding Daxx - a protein associated with the Fas receptor that mediates activation of Jun amino-terminal kinase (JNK) and [programmed cell death] *induced* by . Positive_regulation PDCD11 FAS 1385299 200731 Binding of anti-APO-1 antibody to the *induces* [programmed cell death] ( apoptosis ) . Positive_regulation PDCD11 FAS 14977887 1227991 In fact , G1-overexpressing cells appeared resistant to both cytotoxic drug induced and *dependent* [programmed cell death] , and this resistance implicated mitochondrial apoptotic genes . Positive_regulation PDCD11 FAS 15879137 1406050 Heat killed A. phagocytophilum caused some similar initial alterations in neutrophil gene expression and function , which included delaying normal PMN apoptosis and blocking *induced* [programmed cell death] . Positive_regulation PDCD11 FAS 1689786 128393 Binding of to cells expressing APO-1 *results* in [programmed cell death] , apoptosis , the most common form of death in eukaryotic cells . Positive_regulation PDCD11 FAS 17605793 1774721 Molecular and biochemical assessment of these mutant Fas ligand proteins were carried out by expressing the mutant FasL cDNA in mammalian cells and analysis its effects on *mediated* [programmed cell death] . Positive_regulation PDCD11 FAS 22553782 2590580 However , PI3-K activation is crucial upon the BCR driven anti-apoptotic effect , while p38 MAPK mediated inactivation of caspases seems to play essential role in TLR9 mediated protection against *induced* [programmed cell death] . Positive_regulation PDCD11 FAS 7530337 291603 ( CD95 ) /FasL interactions *required* for [programmed cell death] after T-cell activation . Positive_regulation PDCD11 FAS 7896458 299837 In contrast to malignant cell lines , which express low levels of bax-alpha , non-malignant epithelial cell lines displaying high amounts of bax-alpha were highly sensitive to *induction* of [programmed cell death] by both serum starvation and ( CD95 ) triggering . Positive_regulation PDCD11 FAS 8647190 363428 While in most situations ligation *activates* [programmed cell death] , on resting T lymphocytes it can co-stimulate proliferation with the T cell receptor (TCR)/CD3 complex . Positive_regulation PDCD11 FAS 8670891 375075 Cathepsin D protease mediates [programmed cell death] *induced* by interferon-gamma , and TNF-alpha . Positive_regulation PDCD11 FAS 8758891 377817 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Positive_regulation PDCD11 FAS 8824295 385033 Genetic and pharmacological inhibition of Ras or Rac 1 and Rac 2 stimulation blocks Fas induced apoptosis , pointing to an important function of a Ras and Rac protein regulated signaling pathway in *mediated* [programmed cell death] . Positive_regulation PDCD11 FAS 8943716 400141 *induced* [programmed cell death] is mediated by a Ras regulated O2- synthesis . Positive_regulation PDCD11 FAS 8943716 400149 Likewise , the antioxidants N-acetyl-cysteine and N-t-butyl-phenylnitrone abolished Fas induced cell death , pointing to an important role for Ras triggered ROI synthesis in *mediated* [programmed cell death] . Positive_regulation PDCD11 FAS 8967952 402394 [Programmed cell death] ( apoptosis ) *mediated* by the cytokine receptor is critical for the removal of autoreactive T cells , the mechanism of immune privilege , and for maintenance of immune-system homeostasis . Positive_regulation PDCD11 FAS 9049148 416916 Reactive oxygen species ( ROS ) appear to be involved in *induced* [programmed cell death] . Positive_regulation PDCD11 FAS 9049787 416987 In contrast , rechallenge of previously stimulated lymphocytes with anti-CD3 monoclonal antibody triggered apoptosis in a larger proportion of T cells from cord blood as compared to peripheral blood , whereas the number of T cells undergoing *induced* [programmed cell death] were lower in cord blood compared to peripheral blood . Positive_regulation PDCD11 FAS 9064994 406203 The ( APO-1/Fas ) receptor *mediates* [programmed cell death] in apoptosis sensitive cells upon oligomerization either by CD95 antibody or by its natural ligand , CD95 ligand (CD95 L) . Positive_regulation PDCD11 FAS 9126929 426590 The interaction of ( CD95 ) , a member of the tumor necrosis factor receptor (TNFR) family , and its ligand ( FasL ) *triggers* [programmed cell death] ( apoptosis ) and is involved in the regulation of immune responses . Positive_regulation PDCD11 FAS 9177220 434100 In addition to providing costimulatory signals for cell proliferation , ligation of both TNFR1 and can *result* in [programmed cell death] or apoptosis . Positive_regulation PDCD11 FAS 9207149 440672 The n-type K+ channel ( n-K+ , Kv1.3 ) in lymphocytes has been recently implicated in the regulation of *induced* [programmed cell death] . Positive_regulation PDCD11 FAS 9207415 440816 CD40 and *induce* [programmed cell death] in the human myeloma cell line XG2 . Positive_regulation PDCD11 FAS 9208846 440995 ( CD95 ) ligation *activates* [programmed cell death] , a cellular process that plays an important role in the maturation of the host immune response . Positive_regulation PDCD11 FAS 9350288 460823 The mutation is leaky , allowing for low levels of the APO-1/Fas ( CD95 ) receptor and partial activity of ligand *mediated* [programmed cell death] in this strain . Positive_regulation PDCD11 FAS 9454753 484347 ) *triggers* [programmed cell death] after activation by its ligand and because incubation of human ECFCs with IFNgamma produces apoptosis , we have investigated the expression and function of Fas and Fas ligand (FasL) in highly purified human ECFCs before and after incubation with IFNgamma in vitro . Positive_regulation PDCD11 FAS 9490596 489552 [Programmed cell death] ( apoptosis ) *mediated* by ( CD95 ) , a 45-kD surface protein belonging to the tumor necrosis factor receptor family , is important in the resolution of all inflammatory immune responses . Positive_regulation PDCD11 FAS 9806545 544809 We also found that Pml is essential for *induction* of [programmed cell death] by , tumour necrosis factor alpha (TNF) , ceramide and type I and II interferons ( IFNs ) . Positive_regulation PDCD11 JAG1 16027528 1435882 Evaluation of biochemical and morphological features suggested that the major form of [programmed cell death] *induced* by 115 and EFDAC was autophagy . Positive_regulation PDCD11 MAP2K6 18713014 1974668 signaling *leads* to stimulus-specific changes in gene expression , alterations in cell metabolism or induction of [programmed cell death] ( apoptosis ) , and thus controls cell differentiation and proliferation . Positive_regulation PDCD11 TGM2 11697888 877624 activity is *involved* in polyamine induced [programmed cell death] . Positive_regulation PDCD11 TGM2 24778637 2937144 Senescence and [programmed cell death] in plants : polyamine action *mediated* by . Positive_regulation PDCD11 TNF 10657935 664292 Tumor necrosis factor (TNF) receptor ( TNFR ) -associated factors 1 and 2 ( TRAF1 and TRAF2 ) and inhibitor of apoptosis proteins cIAP1 ( MIHB ) and cIAP2 ( MIHC ) were recently identified as proteins that associate with the TNF-alpha receptors TNFRI ( p55 ) and TNFRII ( p75 ) and inhibit *induced* [programmed cell death] or apoptosis . Positive_regulation PDCD11 TNF 10858960 704745 These proteins are also known to interfere with [programmed cell death] *induced* by and Fas ligand . Positive_regulation PDCD11 TNF 11153078 759049 Since ceramide is an important regulatory molecule of [programmed cell death] *induced* by , we examined whether nef could alter TNF-alpha induced apoptosis in the U251MG human astrocytoma cell line . Positive_regulation PDCD11 TNF 12048203 968536 The activation of AKT2 inhibits UV- and TNF alpha induced c-Jun N-terminal kinase (JNK) and p38 activities that have been shown to be required for stress- and *induced* [programmed cell death] . Positive_regulation PDCD11 TNF 12048203 968545 Furthermore , phosphatidylinositol 3-kinase inhibitor or dominant negative AKT2 significantly enhances UV- and TNF alpha induced apoptosis , whereas expression of constitutively active AKT2 inhibits [programmed cell death] in *response* to UV and -induced apoptosis by inhibition of stress kinases and provide the first evidence that AKT inhibits stress kinase JNK through activation of the NF kappa B pathway . Positive_regulation PDCD11 TNF 12093867 960425 Fas and the *regulate* the [programmed cell death] of lymphocytes . Positive_regulation PDCD11 TNF 12446776 1017909 The proinflammatory cytokine *regulates* immune responses , inflammation , and [programmed cell death] ( apoptosis ) . Positive_regulation PDCD11 TNF 12933798 1151441 Zoledronate sensitizes endothelial cells to *induced* [programmed cell death] : evidence for the suppression of sustained activation of focal adhesion kinase and protein kinase B/Akt . Positive_regulation PDCD11 TNF 12933798 1151449 Taken together these data demonstrate that zoledronate sensitizes endothelial cells to *induced* , caspase independent [programmed cell death] and point to the FAK-PKB/Akt pathway as a novel zoledronate target . Positive_regulation PDCD11 TNF 14989423 1034258 IL-1 and TNFalpha share several biological properties but the salient difference is that receptor signaling *induces* [programmed cell death] whereas IL-1 receptor signaling does not . Positive_regulation PDCD11 TNF 15225801 1268419 Activation of p38 MAP kinase was shown to have both pro- and anti-apoptotic actions in *induced* [programmed cell death] depending on cell context . Positive_regulation PDCD11 TNF 15621052 1358402 *induces* [programmed cell death] and contributes to cardiac ischemia/reperfusion injury . Positive_regulation PDCD11 TNF 16077199 1442297 Apparently , cycloheximide sensitized cells to *induced* [programmed cell death] . Positive_regulation PDCD11 TNF 16083851 1442909 The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase independent [programmed cell death] *mediated* by . Positive_regulation PDCD11 TNF 18064605 1867941 We found that deoxycholyltaurine (DCT) markedly attenuated both unstimulated and *stimulated* [programmed cell death] in colon cancer cells by a phosphatidylinositol 3-kinase (PI3K) dependent mechanism . Positive_regulation PDCD11 TNF 18851874 2000872 Although both L153R and C417R impaired TLR and TNF-alpha induced NF-kappaB activation , L153R also increased *induced* [programmed cell death] with decreased A20 expression . Positive_regulation PDCD11 TNF 19706490 2144762 Expression of HO-1 suppresses the pro-oxidant effects of free heme , preventing it from sensitizing hepatocytes to undergo *mediated* [programmed cell death] by apoptosis . Positive_regulation PDCD11 TNF 20683023 2299011 Heterogeneity of radiation- and *induced* [programmed cell death] in carcinoma , sarcoma and lymphoma cell lines . Positive_regulation PDCD11 TNF 20705491 2312795 A20 is a ubiquitin modifying enzyme that restricts NF-kappaB signals and protects cells against *induced* [programmed cell death] . Positive_regulation PDCD11 TNF 20832854 2325316 It is thus suggested that the co-immobilized TNF-a plus IFN-? promotes the activation of some unknown key markers in response to IFN-? , and the binding of the co-immobilized plus IFN-? with some other TNF-a receptors *results* in enhanced [programmed cell death] in HeLa cells . Positive_regulation PDCD11 TNF 7593233 334604 Interferon-gamma and suppress both early and late stages of hematopoiesis and *induce* [programmed cell death] . Positive_regulation PDCD11 TNF 7600193 311509 The *induction* of accelerated thymic [programmed cell death] during polymicrobial sepsis : control by corticosteroids but not . Positive_regulation PDCD11 TNF 8166195 254827 *Induction* of [programmed cell death] ( apoptosis ) by was quantitated by means of a deoxyribonucleic acid fragmentation assay . Positive_regulation PDCD11 TNF 8627883 356107 Furthermore , by using a nuclease digestion assay , we demonstrated that *activated* a Ca++/Mg++ dependent endonuclease responsible for [programmed cell death] or apoptosis . Positive_regulation PDCD11 TNF 8657285 367001 Ceramide is an important regulatory participant of [programmed cell death] ( apoptosis ) *induced* by and Fas ligand , members of the TNF superfamily . Positive_regulation PDCD11 TNF 8670891 375074 Cathepsin D protease mediates [programmed cell death] *induced* by interferon-gamma , Fas/APO-1 and . Positive_regulation PDCD11 TNF 8670891 375098 Pepstatin A , an inhibitor of cathepsin D , suppressed cell death in these systems and interfered with the *induced* [programmed cell death] of U937 cells as well . Positive_regulation PDCD11 TNF 8758891 377816 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Positive_regulation PDCD11 TNF 9565035 500887 In adenovirus infected cells , [programmed cell death] ( apoptosis ) *induced* by the cytokine is inhibited by several adenovirus encoded proteins . Positive_regulation PDCD11 TNF 9602717 478285 Furthermore , *stimulates* [programmed cell death] ( apoptosis ) in luteal cells kept under culture conditions . Positive_regulation PDCD11 TNF 9806545 544808 We also found that Pml is essential for *induction* of [programmed cell death] by Fas , , ceramide and type I and II interferons ( IFNs ) . Positive_regulation PDCD11 TNFSF10 10960444 726371 Recombinant *induced* extensive [programmed cell death] in cholangiocarcinoma cell lines lacking decoy receptor expression . Positive_regulation PDCD11 TNFSF10 12398939 1008992 can selectively *induce* [programmed cell death] in transformed cells , although its wide tissue distribution suggests potential physiological roles . Positive_regulation PDCD11 TNFSF10 16251995 1525660 Using adenovirus ( Ad ) -mediated gene transfer , we overexpressed the proapoptotic molecules p53 , procaspase 3 , Bax , and to *induce* therapeutic [programmed cell death] of residual lens cells to prevent PCO . Positive_regulation PDCD11 TNFSF10 16651415 1557584 We propose that MNDA has a role regulating programmed cell death in myeloid progenitor cells , and that its down-regulation in MDS is related to granulocyte-macrophage progenitor cell sensitivity to *induced* [programmed cell death] . Positive_regulation PDCD11 TNFSF10 16934748 1608856 In conclusion , alternative splicing might be involved in functional fine tuning of *induced* [programmed cell death] . Positive_regulation PDCD11 TNFSF10 17487744 1739301 Thus , the effect of bexarotene on *mediated* [programmed cell death] involved proximal events of the extrinsic pathway ; Positive_regulation PDCD11 TNFSF10 19196465 2079377 Here , we hypothesise that the susceptibility of RASFs to receptor mediated apoptosis depends on the proliferation status of these cells and therefore analysed the cell cycle dependency of FasL- and *induced* [programmed cell death] of RASFs in vitro . Positive_regulation PDCD11 TNFSF10 21711324 2494349 The accumulation of apoptotic cell debris has been hypothesized to induce this autoimmune inflammation , and may *trigger* this [programmed cell death] . Positive_regulation PDCD11 TNFSF10 23792015 2824243 The accumulation of apoptotic cell debris has been hypothesized to induce the autoimmune inflammation in SLE , and may *trigger* this [programmed cell death] . Positive_regulation PDCD1LG2 CCL17 12909129 1121888 Endogenous CCL17 and [B7-DC] mRNAs were increased similarly in IL-4 cultured DCs but only was *induced* by LPS . Positive_regulation PDCD1LG2 TNF 16129490 1507339 Flow cytometric analysis revealed that B7-H1 but not [B7-DC] constitutively expresses on TECs , and the B7-H1 protein expression was profoundly *up-regulated* by the stimulation of with a dose dependent manner . Positive_regulation PDCD1LG2 TNF 18318992 1881060 PD-L1 expression was repressed and PD-L2 expression remained unchanged in mature CD40 ligated DCs , whereas stimulated DCs kept high expression of PD-L1 and significantly *enhanced* [PD-L2] expression on DCs . Positive_regulation PDCD2 CAPN8 10825507 696656 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Positive_regulation PDCD2 CAPN8 18496573 1965512 ICP10PK inhibits *dependent* release of apoptosis inducing factor and [programmed cell death] in response to the toxin MPP+ . Positive_regulation PDCD2 CAPN8 20224428 2272691 Because beta3 integrin contributes to cardioprotective signaling , these studies indicate that the loss of specific integrin function could be a key mechanism for *mediated* [programmed cell death] of cardiomyocytes in PO myocardium . Positive_regulation PDCD2 CLU 22358960 178193 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Positive_regulation PDCD2 EPHB2 18713014 1974686 signaling *leads* to stimulus-specific changes in gene expression , alterations in cell metabolism or induction of [programmed cell death] ( apoptosis ) , and thus controls cell differentiation and proliferation . Positive_regulation PDCD2 FAS 10352248 617136 Restimulation of Ag receptors on peripheral T lymphocytes induces tyrosine phosphorylation based signaling cascades that evoke Fas ligand expression and induction of *mediated* [programmed cell death] . Positive_regulation PDCD2 FAS 10679090 668766 These results provide evidence that *mediated* [programmed cell death] plays a significant role in the pathogenesis of autoimmune diabetes . Positive_regulation PDCD2 FAS 10722700 677210 Activation of either tumor necrosis factor receptor 1 or *induces* a low level of [programmed cell death] in LNCaP human prostate cancer cells . Positive_regulation PDCD2 FAS 10726692 677724 Ceramides ( known stimuli of apoptosis downstream from the CD95-receptor complex ) also were used to test whether apoptosis would be induced in neuroblastoma cell cultures resistant to *mediated* [programmed cell death] . Positive_regulation PDCD2 FAS 11061245 746372 ( CD95 ) *triggers* [programmed cell death] and is involved in shutting off the immune response . Positive_regulation PDCD2 FAS 11164911 782699 The cellular caspase-inhibitory protein FLIP has been recently identified as a potent regulator of T lymphocyte susceptibility to *mediated* [programmed cell death] ( apoptosis ) . Positive_regulation PDCD2 FAS 11246866 793288 ( CD95 ) *triggers* [programmed cell death] and is involved in cell mediated cytotoxicity and in shutting off the immune response . Positive_regulation PDCD2 FAS 11342432 812722 Surprisingly , it was found that clonogenic progenitors were protected from gammaIFN plus *induced* [programmed cell death] when Lin ( + ) cells were removed from cultured splenocytes . Positive_regulation PDCD2 FAS 11385298 821649 ( CD95 ) and Fas ligand ( FasL/CD95L ) are *involved* in [programmed cell death] and the regulation of host immune responses . Positive_regulation PDCD2 FAS 11483955 844634 Here we have used a screen for proteins that interact physically with the cytoplasmic domain of the type II TGF-beta receptor to isolate the gene encoding Daxx - a protein associated with the Fas receptor that mediates activation of Jun amino-terminal kinase (JNK) and [programmed cell death] *induced* by . Positive_regulation PDCD2 FAS 1385299 200734 Binding of anti-APO-1 antibody to the *induces* [programmed cell death] ( apoptosis ) . Positive_regulation PDCD2 FAS 14977887 1227994 In fact , G1-overexpressing cells appeared resistant to both cytotoxic drug induced and *dependent* [programmed cell death] , and this resistance implicated mitochondrial apoptotic genes . Positive_regulation PDCD2 FAS 15879137 1406053 Heat killed A. phagocytophilum caused some similar initial alterations in neutrophil gene expression and function , which included delaying normal PMN apoptosis and blocking *induced* [programmed cell death] . Positive_regulation PDCD2 FAS 1689786 128396 Binding of to cells expressing APO-1 *results* in [programmed cell death] , apoptosis , the most common form of death in eukaryotic cells . Positive_regulation PDCD2 FAS 17605793 1774724 Molecular and biochemical assessment of these mutant Fas ligand proteins were carried out by expressing the mutant FasL cDNA in mammalian cells and analysis its effects on *mediated* [programmed cell death] . Positive_regulation PDCD2 FAS 22553782 2590583 However , PI3-K activation is crucial upon the BCR driven anti-apoptotic effect , while p38 MAPK mediated inactivation of caspases seems to play essential role in TLR9 mediated protection against *induced* [programmed cell death] . Positive_regulation PDCD2 FAS 7530337 291609 ( CD95 ) /FasL interactions *required* for [programmed cell death] after T-cell activation . Positive_regulation PDCD2 FAS 7896458 299840 In contrast to malignant cell lines , which express low levels of bax-alpha , non-malignant epithelial cell lines displaying high amounts of bax-alpha were highly sensitive to *induction* of [programmed cell death] by both serum starvation and ( CD95 ) triggering . Positive_regulation PDCD2 FAS 8647190 363431 While in most situations ligation *activates* [programmed cell death] , on resting T lymphocytes it can co-stimulate proliferation with the T cell receptor (TCR)/CD3 complex . Positive_regulation PDCD2 FAS 8670891 375084 Cathepsin D protease mediates [programmed cell death] *induced* by interferon-gamma , and TNF-alpha . Positive_regulation PDCD2 FAS 8758891 377823 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Positive_regulation PDCD2 FAS 8824295 385036 Genetic and pharmacological inhibition of Ras or Rac 1 and Rac 2 stimulation blocks Fas induced apoptosis , pointing to an important function of a Ras and Rac protein regulated signaling pathway in *mediated* [programmed cell death] . Positive_regulation PDCD2 FAS 8943716 400144 *induced* [programmed cell death] is mediated by a Ras regulated O2- synthesis . Positive_regulation PDCD2 FAS 8943716 400152 Likewise , the antioxidants N-acetyl-cysteine and N-t-butyl-phenylnitrone abolished Fas induced cell death , pointing to an important role for Ras triggered ROI synthesis in *mediated* [programmed cell death] . Positive_regulation PDCD2 FAS 8967952 402397 [Programmed cell death] ( apoptosis ) *mediated* by the cytokine receptor is critical for the removal of autoreactive T cells , the mechanism of immune privilege , and for maintenance of immune-system homeostasis . Positive_regulation PDCD2 FAS 9049148 416919 Reactive oxygen species ( ROS ) appear to be involved in *induced* [programmed cell death] . Positive_regulation PDCD2 FAS 9049787 416990 In contrast , rechallenge of previously stimulated lymphocytes with anti-CD3 monoclonal antibody triggered apoptosis in a larger proportion of T cells from cord blood as compared to peripheral blood , whereas the number of T cells undergoing *induced* [programmed cell death] were lower in cord blood compared to peripheral blood . Positive_regulation PDCD2 FAS 9064994 406206 The ( APO-1/Fas ) receptor *mediates* [programmed cell death] in apoptosis sensitive cells upon oligomerization either by CD95 antibody or by its natural ligand , CD95 ligand (CD95 L) . Positive_regulation PDCD2 FAS 9126929 426593 The interaction of ( CD95 ) , a member of the tumor necrosis factor receptor (TNFR) family , and its ligand ( FasL ) *triggers* [programmed cell death] ( apoptosis ) and is involved in the regulation of immune responses . Positive_regulation PDCD2 FAS 9177220 434106 In addition to providing costimulatory signals for cell proliferation , ligation of both TNFR1 and can *result* in [programmed cell death] or apoptosis . Positive_regulation PDCD2 FAS 9207149 440675 The n-type K+ channel ( n-K+ , Kv1.3 ) in lymphocytes has been recently implicated in the regulation of *induced* [programmed cell death] . Positive_regulation PDCD2 FAS 9207415 440822 CD40 and *induce* [programmed cell death] in the human myeloma cell line XG2 . Positive_regulation PDCD2 FAS 9208846 440998 ( CD95 ) ligation *activates* [programmed cell death] , a cellular process that plays an important role in the maturation of the host immune response . Positive_regulation PDCD2 FAS 9350288 460829 The mutation is leaky , allowing for low levels of the APO-1/Fas ( CD95 ) receptor and partial activity of ligand *mediated* [programmed cell death] in this strain . Positive_regulation PDCD2 FAS 9454753 484350 ) *triggers* [programmed cell death] after activation by its ligand and because incubation of human ECFCs with IFNgamma produces apoptosis , we have investigated the expression and function of Fas and Fas ligand (FasL) in highly purified human ECFCs before and after incubation with IFNgamma in vitro . Positive_regulation PDCD2 FAS 9490596 489555 [Programmed cell death] ( apoptosis ) *mediated* by ( CD95 ) , a 45-kD surface protein belonging to the tumor necrosis factor receptor family , is important in the resolution of all inflammatory immune responses . Positive_regulation PDCD2 FAS 9806545 544818 We also found that Pml is essential for *induction* of [programmed cell death] by , tumour necrosis factor alpha (TNF) , ceramide and type I and II interferons ( IFNs ) . Positive_regulation PDCD2 JAG1 16027528 1435885 Evaluation of biochemical and morphological features suggested that the major form of [programmed cell death] *induced* by 115 and EFDAC was autophagy . Positive_regulation PDCD2 MAP2K6 18713014 1974692 signaling *leads* to stimulus-specific changes in gene expression , alterations in cell metabolism or induction of [programmed cell death] ( apoptosis ) , and thus controls cell differentiation and proliferation . Positive_regulation PDCD2 TGM2 11697888 877645 activity is *involved* in polyamine induced [programmed cell death] . Positive_regulation PDCD2 TGM2 24778637 2937165 Senescence and [programmed cell death] in plants : polyamine action *mediated* by . Positive_regulation PDCD2 TNF 10657935 664295 Tumor necrosis factor (TNF) receptor ( TNFR ) -associated factors 1 and 2 ( TRAF1 and TRAF2 ) and inhibitor of apoptosis proteins cIAP1 ( MIHB ) and cIAP2 ( MIHC ) were recently identified as proteins that associate with the TNF-alpha receptors TNFRI ( p55 ) and TNFRII ( p75 ) and inhibit *induced* [programmed cell death] or apoptosis . Positive_regulation PDCD2 TNF 10858960 704751 These proteins are also known to interfere with [programmed cell death] *induced* by and Fas ligand . Positive_regulation PDCD2 TNF 11153078 759052 Since ceramide is an important regulatory molecule of [programmed cell death] *induced* by , we examined whether nef could alter TNF-alpha induced apoptosis in the U251MG human astrocytoma cell line . Positive_regulation PDCD2 TNF 12048203 968540 The activation of AKT2 inhibits UV- and TNF alpha induced c-Jun N-terminal kinase (JNK) and p38 activities that have been shown to be required for stress- and *induced* [programmed cell death] . Positive_regulation PDCD2 TNF 12048203 968548 Furthermore , phosphatidylinositol 3-kinase inhibitor or dominant negative AKT2 significantly enhances UV- and TNF alpha induced apoptosis , whereas expression of constitutively active AKT2 inhibits [programmed cell death] in *response* to UV and -induced apoptosis by inhibition of stress kinases and provide the first evidence that AKT inhibits stress kinase JNK through activation of the NF kappa B pathway . Positive_regulation PDCD2 TNF 12093867 960428 Fas and the *regulate* the [programmed cell death] of lymphocytes . Positive_regulation PDCD2 TNF 12446776 1017912 The proinflammatory cytokine *regulates* immune responses , inflammation , and [programmed cell death] ( apoptosis ) . Positive_regulation PDCD2 TNF 12933798 1151444 Zoledronate sensitizes endothelial cells to *induced* [programmed cell death] : evidence for the suppression of sustained activation of focal adhesion kinase and protein kinase B/Akt . Positive_regulation PDCD2 TNF 12933798 1151452 Taken together these data demonstrate that zoledronate sensitizes endothelial cells to *induced* , caspase independent [programmed cell death] and point to the FAK-PKB/Akt pathway as a novel zoledronate target . Positive_regulation PDCD2 TNF 14989423 1034261 IL-1 and TNFalpha share several biological properties but the salient difference is that receptor signaling *induces* [programmed cell death] whereas IL-1 receptor signaling does not . Positive_regulation PDCD2 TNF 15225801 1268422 Activation of p38 MAP kinase was shown to have both pro- and anti-apoptotic actions in *induced* [programmed cell death] depending on cell context . Positive_regulation PDCD2 TNF 15621052 1358405 *induces* [programmed cell death] and contributes to cardiac ischemia/reperfusion injury . Positive_regulation PDCD2 TNF 16077199 1442300 Apparently , cycloheximide sensitized cells to *induced* [programmed cell death] . Positive_regulation PDCD2 TNF 16083851 1442912 The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase independent [programmed cell death] *mediated* by . Positive_regulation PDCD2 TNF 18064605 1867944 We found that deoxycholyltaurine (DCT) markedly attenuated both unstimulated and *stimulated* [programmed cell death] in colon cancer cells by a phosphatidylinositol 3-kinase (PI3K) dependent mechanism . Positive_regulation PDCD2 TNF 18851874 2000876 Although both L153R and C417R impaired TLR and TNF-alpha induced NF-kappaB activation , L153R also increased *induced* [programmed cell death] with decreased A20 expression . Positive_regulation PDCD2 TNF 19706490 2144765 Expression of HO-1 suppresses the pro-oxidant effects of free heme , preventing it from sensitizing hepatocytes to undergo *mediated* [programmed cell death] by apoptosis . Positive_regulation PDCD2 TNF 20683023 2299014 Heterogeneity of radiation- and *induced* [programmed cell death] in carcinoma , sarcoma and lymphoma cell lines . Positive_regulation PDCD2 TNF 20705491 2312798 A20 is a ubiquitin modifying enzyme that restricts NF-kappaB signals and protects cells against *induced* [programmed cell death] . Positive_regulation PDCD2 TNF 20832854 2325319 It is thus suggested that the co-immobilized TNF-a plus IFN-? promotes the activation of some unknown key markers in response to IFN-? , and the binding of the co-immobilized plus IFN-? with some other TNF-a receptors *results* in enhanced [programmed cell death] in HeLa cells . Positive_regulation PDCD2 TNF 7593233 334618 Interferon-gamma and suppress both early and late stages of hematopoiesis and *induce* [programmed cell death] . Positive_regulation PDCD2 TNF 7600193 311512 The *induction* of accelerated thymic [programmed cell death] during polymicrobial sepsis : control by corticosteroids but not . Positive_regulation PDCD2 TNF 8166195 254830 *Induction* of [programmed cell death] ( apoptosis ) by was quantitated by means of a deoxyribonucleic acid fragmentation assay . Positive_regulation PDCD2 TNF 8627883 356110 Furthermore , by using a nuclease digestion assay , we demonstrated that *activated* a Ca++/Mg++ dependent endonuclease responsible for [programmed cell death] or apoptosis . Positive_regulation PDCD2 TNF 8657285 367007 Ceramide is an important regulatory participant of [programmed cell death] ( apoptosis ) *induced* by and Fas ligand , members of the TNF superfamily . Positive_regulation PDCD2 TNF 8670891 375083 Cathepsin D protease mediates [programmed cell death] *induced* by interferon-gamma , Fas/APO-1 and . Positive_regulation PDCD2 TNF 8670891 375101 Pepstatin A , an inhibitor of cathepsin D , suppressed cell death in these systems and interfered with the *induced* [programmed cell death] of U937 cells as well . Positive_regulation PDCD2 TNF 8758891 377822 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Positive_regulation PDCD2 TNF 9565035 500890 In adenovirus infected cells , [programmed cell death] ( apoptosis ) *induced* by the cytokine is inhibited by several adenovirus encoded proteins . Positive_regulation PDCD2 TNF 9602717 478288 Furthermore , *stimulates* [programmed cell death] ( apoptosis ) in luteal cells kept under culture conditions . Positive_regulation PDCD2 TNF 9806545 544817 We also found that Pml is essential for *induction* of [programmed cell death] by Fas , , ceramide and type I and II interferons ( IFNs ) . Positive_regulation PDCD2 TNFSF10 10960444 726374 Recombinant *induced* extensive [programmed cell death] in cholangiocarcinoma cell lines lacking decoy receptor expression . Positive_regulation PDCD2 TNFSF10 12398939 1008995 can selectively *induce* [programmed cell death] in transformed cells , although its wide tissue distribution suggests potential physiological roles . Positive_regulation PDCD2 TNFSF10 16251995 1525666 Using adenovirus ( Ad ) -mediated gene transfer , we overexpressed the proapoptotic molecules p53 , procaspase 3 , Bax , and to *induce* therapeutic [programmed cell death] of residual lens cells to prevent PCO . Positive_regulation PDCD2 TNFSF10 16651415 1557587 We propose that MNDA has a role regulating programmed cell death in myeloid progenitor cells , and that its down-regulation in MDS is related to granulocyte-macrophage progenitor cell sensitivity to *induced* [programmed cell death] . Positive_regulation PDCD2 TNFSF10 16934748 1608859 In conclusion , alternative splicing might be involved in functional fine tuning of *induced* [programmed cell death] . Positive_regulation PDCD2 TNFSF10 17487744 1739304 Thus , the effect of bexarotene on *mediated* [programmed cell death] involved proximal events of the extrinsic pathway ; Positive_regulation PDCD2 TNFSF10 19196465 2079380 Here , we hypothesise that the susceptibility of RASFs to receptor mediated apoptosis depends on the proliferation status of these cells and therefore analysed the cell cycle dependency of FasL- and *induced* [programmed cell death] of RASFs in vitro . Positive_regulation PDCD2 TNFSF10 21711324 2494352 The accumulation of apoptotic cell debris has been hypothesized to induce this autoimmune inflammation , and may *trigger* this [programmed cell death] . Positive_regulation PDCD2 TNFSF10 23792015 2824246 The accumulation of apoptotic cell debris has been hypothesized to induce the autoimmune inflammation in SLE , and may *trigger* this [programmed cell death] . Positive_regulation PDCD4 CAPN8 10825507 696670 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Positive_regulation PDCD4 CAPN8 18496573 1965527 ICP10PK inhibits *dependent* release of apoptosis inducing factor and [programmed cell death] in response to the toxin MPP+ . Positive_regulation PDCD4 CAPN8 20224428 2272705 Because beta3 integrin contributes to cardioprotective signaling , these studies indicate that the loss of specific integrin function could be a key mechanism for *mediated* [programmed cell death] of cardiomyocytes in PO myocardium . Positive_regulation PDCD4 CLU 22358960 178194 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Positive_regulation PDCD4 EPHB2 18713014 1974694 signaling *leads* to stimulus-specific changes in gene expression , alterations in cell metabolism or induction of [programmed cell death] ( apoptosis ) , and thus controls cell differentiation and proliferation . Positive_regulation PDCD4 FAS 10352248 617137 Restimulation of Ag receptors on peripheral T lymphocytes induces tyrosine phosphorylation based signaling cascades that evoke Fas ligand expression and induction of *mediated* [programmed cell death] . Positive_regulation PDCD4 FAS 10679090 668768 These results provide evidence that *mediated* [programmed cell death] plays a significant role in the pathogenesis of autoimmune diabetes . Positive_regulation PDCD4 FAS 10722700 677212 Activation of either tumor necrosis factor receptor 1 or *induces* a low level of [programmed cell death] in LNCaP human prostate cancer cells . Positive_regulation PDCD4 FAS 10726692 677725 Ceramides ( known stimuli of apoptosis downstream from the CD95-receptor complex ) also were used to test whether apoptosis would be induced in neuroblastoma cell cultures resistant to *mediated* [programmed cell death] . Positive_regulation PDCD4 FAS 11061245 746373 ( CD95 ) *triggers* [programmed cell death] and is involved in shutting off the immune response . Positive_regulation PDCD4 FAS 11164911 782700 The cellular caspase-inhibitory protein FLIP has been recently identified as a potent regulator of T lymphocyte susceptibility to *mediated* [programmed cell death] ( apoptosis ) . Positive_regulation PDCD4 FAS 11246866 793289 ( CD95 ) *triggers* [programmed cell death] and is involved in cell mediated cytotoxicity and in shutting off the immune response . Positive_regulation PDCD4 FAS 11342432 812723 Surprisingly , it was found that clonogenic progenitors were protected from gammaIFN plus *induced* [programmed cell death] when Lin ( + ) cells were removed from cultured splenocytes . Positive_regulation PDCD4 FAS 11385298 821651 ( CD95 ) and Fas ligand ( FasL/CD95L ) are *involved* in [programmed cell death] and the regulation of host immune responses . Positive_regulation PDCD4 FAS 11483955 844635 Here we have used a screen for proteins that interact physically with the cytoplasmic domain of the type II TGF-beta receptor to isolate the gene encoding Daxx - a protein associated with the Fas receptor that mediates activation of Jun amino-terminal kinase (JNK) and [programmed cell death] *induced* by . Positive_regulation PDCD4 FAS 1385299 200735 Binding of anti-APO-1 antibody to the *induces* [programmed cell death] ( apoptosis ) . Positive_regulation PDCD4 FAS 14977887 1227995 In fact , G1-overexpressing cells appeared resistant to both cytotoxic drug induced and *dependent* [programmed cell death] , and this resistance implicated mitochondrial apoptotic genes . Positive_regulation PDCD4 FAS 15879137 1406054 Heat killed A. phagocytophilum caused some similar initial alterations in neutrophil gene expression and function , which included delaying normal PMN apoptosis and blocking *induced* [programmed cell death] . Positive_regulation PDCD4 FAS 1689786 128397 Binding of to cells expressing APO-1 *results* in [programmed cell death] , apoptosis , the most common form of death in eukaryotic cells . Positive_regulation PDCD4 FAS 17605793 1774725 Molecular and biochemical assessment of these mutant Fas ligand proteins were carried out by expressing the mutant FasL cDNA in mammalian cells and analysis its effects on *mediated* [programmed cell death] . Positive_regulation PDCD4 FAS 22553782 2590584 However , PI3-K activation is crucial upon the BCR driven anti-apoptotic effect , while p38 MAPK mediated inactivation of caspases seems to play essential role in TLR9 mediated protection against *induced* [programmed cell death] . Positive_regulation PDCD4 FAS 7530337 291611 ( CD95 ) /FasL interactions *required* for [programmed cell death] after T-cell activation . Positive_regulation PDCD4 FAS 7896458 299841 In contrast to malignant cell lines , which express low levels of bax-alpha , non-malignant epithelial cell lines displaying high amounts of bax-alpha were highly sensitive to *induction* of [programmed cell death] by both serum starvation and ( CD95 ) triggering . Positive_regulation PDCD4 FAS 8647190 363432 While in most situations ligation *activates* [programmed cell death] , on resting T lymphocytes it can co-stimulate proliferation with the T cell receptor (TCR)/CD3 complex . Positive_regulation PDCD4 FAS 8670891 375087 Cathepsin D protease mediates [programmed cell death] *induced* by interferon-gamma , and TNF-alpha . Positive_regulation PDCD4 FAS 8758891 377825 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Positive_regulation PDCD4 FAS 8824295 385037 Genetic and pharmacological inhibition of Ras or Rac 1 and Rac 2 stimulation blocks Fas induced apoptosis , pointing to an important function of a Ras and Rac protein regulated signaling pathway in *mediated* [programmed cell death] . Positive_regulation PDCD4 FAS 8943716 400145 *induced* [programmed cell death] is mediated by a Ras regulated O2- synthesis . Positive_regulation PDCD4 FAS 8943716 400153 Likewise , the antioxidants N-acetyl-cysteine and N-t-butyl-phenylnitrone abolished Fas induced cell death , pointing to an important role for Ras triggered ROI synthesis in *mediated* [programmed cell death] . Positive_regulation PDCD4 FAS 8967952 402398 [Programmed cell death] ( apoptosis ) *mediated* by the cytokine receptor is critical for the removal of autoreactive T cells , the mechanism of immune privilege , and for maintenance of immune-system homeostasis . Positive_regulation PDCD4 FAS 9049148 416920 Reactive oxygen species ( ROS ) appear to be involved in *induced* [programmed cell death] . Positive_regulation PDCD4 FAS 9049787 416991 In contrast , rechallenge of previously stimulated lymphocytes with anti-CD3 monoclonal antibody triggered apoptosis in a larger proportion of T cells from cord blood as compared to peripheral blood , whereas the number of T cells undergoing *induced* [programmed cell death] were lower in cord blood compared to peripheral blood . Positive_regulation PDCD4 FAS 9064994 406207 The ( APO-1/Fas ) receptor *mediates* [programmed cell death] in apoptosis sensitive cells upon oligomerization either by CD95 antibody or by its natural ligand , CD95 ligand (CD95 L) . Positive_regulation PDCD4 FAS 9126929 426594 The interaction of ( CD95 ) , a member of the tumor necrosis factor receptor (TNFR) family , and its ligand ( FasL ) *triggers* [programmed cell death] ( apoptosis ) and is involved in the regulation of immune responses . Positive_regulation PDCD4 FAS 9177220 434108 In addition to providing costimulatory signals for cell proliferation , ligation of both TNFR1 and can *result* in [programmed cell death] or apoptosis . Positive_regulation PDCD4 FAS 9207149 440676 The n-type K+ channel ( n-K+ , Kv1.3 ) in lymphocytes has been recently implicated in the regulation of *induced* [programmed cell death] . Positive_regulation PDCD4 FAS 9207415 440824 CD40 and *induce* [programmed cell death] in the human myeloma cell line XG2 . Positive_regulation PDCD4 FAS 9208846 440999 ( CD95 ) ligation *activates* [programmed cell death] , a cellular process that plays an important role in the maturation of the host immune response . Positive_regulation PDCD4 FAS 9350288 460831 The mutation is leaky , allowing for low levels of the APO-1/Fas ( CD95 ) receptor and partial activity of ligand *mediated* [programmed cell death] in this strain . Positive_regulation PDCD4 FAS 9454753 484351 ) *triggers* [programmed cell death] after activation by its ligand and because incubation of human ECFCs with IFNgamma produces apoptosis , we have investigated the expression and function of Fas and Fas ligand (FasL) in highly purified human ECFCs before and after incubation with IFNgamma in vitro . Positive_regulation PDCD4 FAS 9490596 489556 [Programmed cell death] ( apoptosis ) *mediated* by ( CD95 ) , a 45-kD surface protein belonging to the tumor necrosis factor receptor family , is important in the resolution of all inflammatory immune responses . Positive_regulation PDCD4 FAS 9806545 544821 We also found that Pml is essential for *induction* of [programmed cell death] by , tumour necrosis factor alpha (TNF) , ceramide and type I and II interferons ( IFNs ) . Positive_regulation PDCD4 JAG1 16027528 1435886 Evaluation of biochemical and morphological features suggested that the major form of [programmed cell death] *induced* by 115 and EFDAC was autophagy . Positive_regulation PDCD4 MAP2K6 18713014 1974700 signaling *leads* to stimulus-specific changes in gene expression , alterations in cell metabolism or induction of [programmed cell death] ( apoptosis ) , and thus controls cell differentiation and proliferation . Positive_regulation PDCD4 TGM2 11697888 877652 activity is *involved* in polyamine induced [programmed cell death] . Positive_regulation PDCD4 TGM2 24778637 2937172 Senescence and [programmed cell death] in plants : polyamine action *mediated* by . Positive_regulation PDCD4 TNF 10657935 664296 Tumor necrosis factor (TNF) receptor ( TNFR ) -associated factors 1 and 2 ( TRAF1 and TRAF2 ) and inhibitor of apoptosis proteins cIAP1 ( MIHB ) and cIAP2 ( MIHC ) were recently identified as proteins that associate with the TNF-alpha receptors TNFRI ( p55 ) and TNFRII ( p75 ) and inhibit *induced* [programmed cell death] or apoptosis . Positive_regulation PDCD4 TNF 10858960 704753 These proteins are also known to interfere with [programmed cell death] *induced* by and Fas ligand . Positive_regulation PDCD4 TNF 11153078 759053 Since ceramide is an important regulatory molecule of [programmed cell death] *induced* by , we examined whether nef could alter TNF-alpha induced apoptosis in the U251MG human astrocytoma cell line . Positive_regulation PDCD4 TNF 12048203 968541 The activation of AKT2 inhibits UV- and TNF alpha induced c-Jun N-terminal kinase (JNK) and p38 activities that have been shown to be required for stress- and *induced* [programmed cell death] . Positive_regulation PDCD4 TNF 12048203 968549 Furthermore , phosphatidylinositol 3-kinase inhibitor or dominant negative AKT2 significantly enhances UV- and TNF alpha induced apoptosis , whereas expression of constitutively active AKT2 inhibits [programmed cell death] in *response* to UV and -induced apoptosis by inhibition of stress kinases and provide the first evidence that AKT inhibits stress kinase JNK through activation of the NF kappa B pathway . Positive_regulation PDCD4 TNF 12093867 960429 Fas and the *regulate* the [programmed cell death] of lymphocytes . Positive_regulation PDCD4 TNF 12446776 1017913 The proinflammatory cytokine *regulates* immune responses , inflammation , and [programmed cell death] ( apoptosis ) . Positive_regulation PDCD4 TNF 12933798 1151445 Zoledronate sensitizes endothelial cells to *induced* [programmed cell death] : evidence for the suppression of sustained activation of focal adhesion kinase and protein kinase B/Akt . Positive_regulation PDCD4 TNF 12933798 1151453 Taken together these data demonstrate that zoledronate sensitizes endothelial cells to *induced* , caspase independent [programmed cell death] and point to the FAK-PKB/Akt pathway as a novel zoledronate target . Positive_regulation PDCD4 TNF 14989423 1034262 IL-1 and TNFalpha share several biological properties but the salient difference is that receptor signaling *induces* [programmed cell death] whereas IL-1 receptor signaling does not . Positive_regulation PDCD4 TNF 15225801 1268423 Activation of p38 MAP kinase was shown to have both pro- and anti-apoptotic actions in *induced* [programmed cell death] depending on cell context . Positive_regulation PDCD4 TNF 15621052 1358406 *induces* [programmed cell death] and contributes to cardiac ischemia/reperfusion injury . Positive_regulation PDCD4 TNF 16077199 1442301 Apparently , cycloheximide sensitized cells to *induced* [programmed cell death] . Positive_regulation PDCD4 TNF 16083851 1442913 The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase independent [programmed cell death] *mediated* by . Positive_regulation PDCD4 TNF 18064605 1867945 We found that deoxycholyltaurine (DCT) markedly attenuated both unstimulated and *stimulated* [programmed cell death] in colon cancer cells by a phosphatidylinositol 3-kinase (PI3K) dependent mechanism . Positive_regulation PDCD4 TNF 18851874 2000877 Although both L153R and C417R impaired TLR and TNF-alpha induced NF-kappaB activation , L153R also increased *induced* [programmed cell death] with decreased A20 expression . Positive_regulation PDCD4 TNF 19706490 2144766 Expression of HO-1 suppresses the pro-oxidant effects of free heme , preventing it from sensitizing hepatocytes to undergo *mediated* [programmed cell death] by apoptosis . Positive_regulation PDCD4 TNF 20683023 2299015 Heterogeneity of radiation- and *induced* [programmed cell death] in carcinoma , sarcoma and lymphoma cell lines . Positive_regulation PDCD4 TNF 20705491 2312799 A20 is a ubiquitin modifying enzyme that restricts NF-kappaB signals and protects cells against *induced* [programmed cell death] . Positive_regulation PDCD4 TNF 20832854 2325320 It is thus suggested that the co-immobilized TNF-a plus IFN-? promotes the activation of some unknown key markers in response to IFN-? , and the binding of the co-immobilized plus IFN-? with some other TNF-a receptors *results* in enhanced [programmed cell death] in HeLa cells . Positive_regulation PDCD4 TNF 23281820 2775389 Rapamycin increased PDCD4 expression via the inhibition of *induced* [PDCD4] degradation in orbital fibroblasts . Positive_regulation PDCD4 TNF 7593233 334620 Interferon-gamma and suppress both early and late stages of hematopoiesis and *induce* [programmed cell death] . Positive_regulation PDCD4 TNF 7600193 311513 The *induction* of accelerated thymic [programmed cell death] during polymicrobial sepsis : control by corticosteroids but not . Positive_regulation PDCD4 TNF 8166195 254831 *Induction* of [programmed cell death] ( apoptosis ) by was quantitated by means of a deoxyribonucleic acid fragmentation assay . Positive_regulation PDCD4 TNF 8627883 356111 Furthermore , by using a nuclease digestion assay , we demonstrated that *activated* a Ca++/Mg++ dependent endonuclease responsible for [programmed cell death] or apoptosis . Positive_regulation PDCD4 TNF 8657285 367009 Ceramide is an important regulatory participant of [programmed cell death] ( apoptosis ) *induced* by and Fas ligand , members of the TNF superfamily . Positive_regulation PDCD4 TNF 8670891 375086 Cathepsin D protease mediates [programmed cell death] *induced* by interferon-gamma , Fas/APO-1 and . Positive_regulation PDCD4 TNF 8670891 375102 Pepstatin A , an inhibitor of cathepsin D , suppressed cell death in these systems and interfered with the *induced* [programmed cell death] of U937 cells as well . Positive_regulation PDCD4 TNF 8758891 377824 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Positive_regulation PDCD4 TNF 9565035 500891 In adenovirus infected cells , [programmed cell death] ( apoptosis ) *induced* by the cytokine is inhibited by several adenovirus encoded proteins . Positive_regulation PDCD4 TNF 9602717 478289 Furthermore , *stimulates* [programmed cell death] ( apoptosis ) in luteal cells kept under culture conditions . Positive_regulation PDCD4 TNF 9806545 544820 We also found that Pml is essential for *induction* of [programmed cell death] by Fas , , ceramide and type I and II interferons ( IFNs ) . Positive_regulation PDCD4 TNFSF10 10960444 726375 Recombinant *induced* extensive [programmed cell death] in cholangiocarcinoma cell lines lacking decoy receptor expression . Positive_regulation PDCD4 TNFSF10 12398939 1008996 can selectively *induce* [programmed cell death] in transformed cells , although its wide tissue distribution suggests potential physiological roles . Positive_regulation PDCD4 TNFSF10 16251995 1525668 Using adenovirus ( Ad ) -mediated gene transfer , we overexpressed the proapoptotic molecules p53 , procaspase 3 , Bax , and to *induce* therapeutic [programmed cell death] of residual lens cells to prevent PCO . Positive_regulation PDCD4 TNFSF10 16651415 1557588 We propose that MNDA has a role regulating programmed cell death in myeloid progenitor cells , and that its down-regulation in MDS is related to granulocyte-macrophage progenitor cell sensitivity to *induced* [programmed cell death] . Positive_regulation PDCD4 TNFSF10 16934748 1608860 In conclusion , alternative splicing might be involved in functional fine tuning of *induced* [programmed cell death] . Positive_regulation PDCD4 TNFSF10 17487744 1739305 Thus , the effect of bexarotene on *mediated* [programmed cell death] involved proximal events of the extrinsic pathway ; Positive_regulation PDCD4 TNFSF10 19196465 2079381 Here , we hypothesise that the susceptibility of RASFs to receptor mediated apoptosis depends on the proliferation status of these cells and therefore analysed the cell cycle dependency of FasL- and *induced* [programmed cell death] of RASFs in vitro . Positive_regulation PDCD4 TNFSF10 21711324 2494353 The accumulation of apoptotic cell debris has been hypothesized to induce this autoimmune inflammation , and may *trigger* this [programmed cell death] . Positive_regulation PDCD4 TNFSF10 23792015 2824247 The accumulation of apoptotic cell debris has been hypothesized to induce the autoimmune inflammation in SLE , and may *trigger* this [programmed cell death] . Positive_regulation PDCD5 CAPN8 10825507 696684 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Positive_regulation PDCD5 CAPN8 18496573 1965542 ICP10PK inhibits *dependent* release of apoptosis inducing factor and [programmed cell death] in response to the toxin MPP+ . Positive_regulation PDCD5 CAPN8 20224428 2272719 Because beta3 integrin contributes to cardioprotective signaling , these studies indicate that the loss of specific integrin function could be a key mechanism for *mediated* [programmed cell death] of cardiomyocytes in PO myocardium . Positive_regulation PDCD5 CLU 22358960 178195 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Positive_regulation PDCD5 EPHB2 18713014 1974702 signaling *leads* to stimulus-specific changes in gene expression , alterations in cell metabolism or induction of [programmed cell death] ( apoptosis ) , and thus controls cell differentiation and proliferation . Positive_regulation PDCD5 FAS 10352248 617138 Restimulation of Ag receptors on peripheral T lymphocytes induces tyrosine phosphorylation based signaling cascades that evoke Fas ligand expression and induction of *mediated* [programmed cell death] . Positive_regulation PDCD5 FAS 10679090 668770 These results provide evidence that *mediated* [programmed cell death] plays a significant role in the pathogenesis of autoimmune diabetes . Positive_regulation PDCD5 FAS 10722700 677214 Activation of either tumor necrosis factor receptor 1 or *induces* a low level of [programmed cell death] in LNCaP human prostate cancer cells . Positive_regulation PDCD5 FAS 10726692 677726 Ceramides ( known stimuli of apoptosis downstream from the CD95-receptor complex ) also were used to test whether apoptosis would be induced in neuroblastoma cell cultures resistant to *mediated* [programmed cell death] . Positive_regulation PDCD5 FAS 11061245 746374 ( CD95 ) *triggers* [programmed cell death] and is involved in shutting off the immune response . Positive_regulation PDCD5 FAS 11164911 782701 The cellular caspase-inhibitory protein FLIP has been recently identified as a potent regulator of T lymphocyte susceptibility to *mediated* [programmed cell death] ( apoptosis ) . Positive_regulation PDCD5 FAS 11246866 793290 ( CD95 ) *triggers* [programmed cell death] and is involved in cell mediated cytotoxicity and in shutting off the immune response . Positive_regulation PDCD5 FAS 11342432 812724 Surprisingly , it was found that clonogenic progenitors were protected from gammaIFN plus *induced* [programmed cell death] when Lin ( + ) cells were removed from cultured splenocytes . Positive_regulation PDCD5 FAS 11385298 821653 ( CD95 ) and Fas ligand ( FasL/CD95L ) are *involved* in [programmed cell death] and the regulation of host immune responses . Positive_regulation PDCD5 FAS 11483955 844636 Here we have used a screen for proteins that interact physically with the cytoplasmic domain of the type II TGF-beta receptor to isolate the gene encoding Daxx - a protein associated with the Fas receptor that mediates activation of Jun amino-terminal kinase (JNK) and [programmed cell death] *induced* by . Positive_regulation PDCD5 FAS 1385299 200736 Binding of anti-APO-1 antibody to the *induces* [programmed cell death] ( apoptosis ) . Positive_regulation PDCD5 FAS 14977887 1227996 In fact , G1-overexpressing cells appeared resistant to both cytotoxic drug induced and *dependent* [programmed cell death] , and this resistance implicated mitochondrial apoptotic genes . Positive_regulation PDCD5 FAS 15879137 1406055 Heat killed A. phagocytophilum caused some similar initial alterations in neutrophil gene expression and function , which included delaying normal PMN apoptosis and blocking *induced* [programmed cell death] . Positive_regulation PDCD5 FAS 1689786 128398 Binding of to cells expressing APO-1 *results* in [programmed cell death] , apoptosis , the most common form of death in eukaryotic cells . Positive_regulation PDCD5 FAS 17605793 1774726 Molecular and biochemical assessment of these mutant Fas ligand proteins were carried out by expressing the mutant FasL cDNA in mammalian cells and analysis its effects on *mediated* [programmed cell death] . Positive_regulation PDCD5 FAS 22553782 2590585 However , PI3-K activation is crucial upon the BCR driven anti-apoptotic effect , while p38 MAPK mediated inactivation of caspases seems to play essential role in TLR9 mediated protection against *induced* [programmed cell death] . Positive_regulation PDCD5 FAS 7530337 291613 ( CD95 ) /FasL interactions *required* for [programmed cell death] after T-cell activation . Positive_regulation PDCD5 FAS 7896458 299842 In contrast to malignant cell lines , which express low levels of bax-alpha , non-malignant epithelial cell lines displaying high amounts of bax-alpha were highly sensitive to *induction* of [programmed cell death] by both serum starvation and ( CD95 ) triggering . Positive_regulation PDCD5 FAS 8647190 363433 While in most situations ligation *activates* [programmed cell death] , on resting T lymphocytes it can co-stimulate proliferation with the T cell receptor (TCR)/CD3 complex . Positive_regulation PDCD5 FAS 8670891 375090 Cathepsin D protease mediates [programmed cell death] *induced* by interferon-gamma , and TNF-alpha . Positive_regulation PDCD5 FAS 8758891 377827 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Positive_regulation PDCD5 FAS 8824295 385038 Genetic and pharmacological inhibition of Ras or Rac 1 and Rac 2 stimulation blocks Fas induced apoptosis , pointing to an important function of a Ras and Rac protein regulated signaling pathway in *mediated* [programmed cell death] . Positive_regulation PDCD5 FAS 8943716 400146 *induced* [programmed cell death] is mediated by a Ras regulated O2- synthesis . Positive_regulation PDCD5 FAS 8943716 400154 Likewise , the antioxidants N-acetyl-cysteine and N-t-butyl-phenylnitrone abolished Fas induced cell death , pointing to an important role for Ras triggered ROI synthesis in *mediated* [programmed cell death] . Positive_regulation PDCD5 FAS 8967952 402399 [Programmed cell death] ( apoptosis ) *mediated* by the cytokine receptor is critical for the removal of autoreactive T cells , the mechanism of immune privilege , and for maintenance of immune-system homeostasis . Positive_regulation PDCD5 FAS 9049148 416921 Reactive oxygen species ( ROS ) appear to be involved in *induced* [programmed cell death] . Positive_regulation PDCD5 FAS 9049787 416992 In contrast , rechallenge of previously stimulated lymphocytes with anti-CD3 monoclonal antibody triggered apoptosis in a larger proportion of T cells from cord blood as compared to peripheral blood , whereas the number of T cells undergoing *induced* [programmed cell death] were lower in cord blood compared to peripheral blood . Positive_regulation PDCD5 FAS 9064994 406208 The ( APO-1/Fas ) receptor *mediates* [programmed cell death] in apoptosis sensitive cells upon oligomerization either by CD95 antibody or by its natural ligand , CD95 ligand (CD95 L) . Positive_regulation PDCD5 FAS 9126929 426595 The interaction of ( CD95 ) , a member of the tumor necrosis factor receptor (TNFR) family , and its ligand ( FasL ) *triggers* [programmed cell death] ( apoptosis ) and is involved in the regulation of immune responses . Positive_regulation PDCD5 FAS 9177220 434110 In addition to providing costimulatory signals for cell proliferation , ligation of both TNFR1 and can *result* in [programmed cell death] or apoptosis . Positive_regulation PDCD5 FAS 9207149 440677 The n-type K+ channel ( n-K+ , Kv1.3 ) in lymphocytes has been recently implicated in the regulation of *induced* [programmed cell death] . Positive_regulation PDCD5 FAS 9207415 440826 CD40 and *induce* [programmed cell death] in the human myeloma cell line XG2 . Positive_regulation PDCD5 FAS 9208846 441000 ( CD95 ) ligation *activates* [programmed cell death] , a cellular process that plays an important role in the maturation of the host immune response . Positive_regulation PDCD5 FAS 9350288 460833 The mutation is leaky , allowing for low levels of the APO-1/Fas ( CD95 ) receptor and partial activity of ligand *mediated* [programmed cell death] in this strain . Positive_regulation PDCD5 FAS 9454753 484352 ) *triggers* [programmed cell death] after activation by its ligand and because incubation of human ECFCs with IFNgamma produces apoptosis , we have investigated the expression and function of Fas and Fas ligand (FasL) in highly purified human ECFCs before and after incubation with IFNgamma in vitro . Positive_regulation PDCD5 FAS 9490596 489557 [Programmed cell death] ( apoptosis ) *mediated* by ( CD95 ) , a 45-kD surface protein belonging to the tumor necrosis factor receptor family , is important in the resolution of all inflammatory immune responses . Positive_regulation PDCD5 FAS 9806545 544824 We also found that Pml is essential for *induction* of [programmed cell death] by , tumour necrosis factor alpha (TNF) , ceramide and type I and II interferons ( IFNs ) . Positive_regulation PDCD5 JAG1 16027528 1435887 Evaluation of biochemical and morphological features suggested that the major form of [programmed cell death] *induced* by 115 and EFDAC was autophagy . Positive_regulation PDCD5 MAP2K6 18713014 1974708 signaling *leads* to stimulus-specific changes in gene expression , alterations in cell metabolism or induction of [programmed cell death] ( apoptosis ) , and thus controls cell differentiation and proliferation . Positive_regulation PDCD5 TGM2 11697888 877659 activity is *involved* in polyamine induced [programmed cell death] . Positive_regulation PDCD5 TGM2 24778637 2937179 Senescence and [programmed cell death] in plants : polyamine action *mediated* by . Positive_regulation PDCD5 TNF 10657935 664297 Tumor necrosis factor (TNF) receptor ( TNFR ) -associated factors 1 and 2 ( TRAF1 and TRAF2 ) and inhibitor of apoptosis proteins cIAP1 ( MIHB ) and cIAP2 ( MIHC ) were recently identified as proteins that associate with the TNF-alpha receptors TNFRI ( p55 ) and TNFRII ( p75 ) and inhibit *induced* [programmed cell death] or apoptosis . Positive_regulation PDCD5 TNF 10858960 704755 These proteins are also known to interfere with [programmed cell death] *induced* by and Fas ligand . Positive_regulation PDCD5 TNF 11153078 759054 Since ceramide is an important regulatory molecule of [programmed cell death] *induced* by , we examined whether nef could alter TNF-alpha induced apoptosis in the U251MG human astrocytoma cell line . Positive_regulation PDCD5 TNF 12048203 968542 The activation of AKT2 inhibits UV- and TNF alpha induced c-Jun N-terminal kinase (JNK) and p38 activities that have been shown to be required for stress- and *induced* [programmed cell death] . Positive_regulation PDCD5 TNF 12048203 968550 Furthermore , phosphatidylinositol 3-kinase inhibitor or dominant negative AKT2 significantly enhances UV- and TNF alpha induced apoptosis , whereas expression of constitutively active AKT2 inhibits [programmed cell death] in *response* to UV and -induced apoptosis by inhibition of stress kinases and provide the first evidence that AKT inhibits stress kinase JNK through activation of the NF kappa B pathway . Positive_regulation PDCD5 TNF 12093867 960430 Fas and the *regulate* the [programmed cell death] of lymphocytes . Positive_regulation PDCD5 TNF 12446776 1017914 The proinflammatory cytokine *regulates* immune responses , inflammation , and [programmed cell death] ( apoptosis ) . Positive_regulation PDCD5 TNF 12933798 1151446 Zoledronate sensitizes endothelial cells to *induced* [programmed cell death] : evidence for the suppression of sustained activation of focal adhesion kinase and protein kinase B/Akt . Positive_regulation PDCD5 TNF 12933798 1151454 Taken together these data demonstrate that zoledronate sensitizes endothelial cells to *induced* , caspase independent [programmed cell death] and point to the FAK-PKB/Akt pathway as a novel zoledronate target . Positive_regulation PDCD5 TNF 14989423 1034263 IL-1 and TNFalpha share several biological properties but the salient difference is that receptor signaling *induces* [programmed cell death] whereas IL-1 receptor signaling does not . Positive_regulation PDCD5 TNF 15225801 1268424 Activation of p38 MAP kinase was shown to have both pro- and anti-apoptotic actions in *induced* [programmed cell death] depending on cell context . Positive_regulation PDCD5 TNF 15621052 1358407 *induces* [programmed cell death] and contributes to cardiac ischemia/reperfusion injury . Positive_regulation PDCD5 TNF 16077199 1442302 Apparently , cycloheximide sensitized cells to *induced* [programmed cell death] . Positive_regulation PDCD5 TNF 16083851 1442914 The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase independent [programmed cell death] *mediated* by . Positive_regulation PDCD5 TNF 18064605 1867946 We found that deoxycholyltaurine (DCT) markedly attenuated both unstimulated and *stimulated* [programmed cell death] in colon cancer cells by a phosphatidylinositol 3-kinase (PI3K) dependent mechanism . Positive_regulation PDCD5 TNF 18851874 2000878 Although both L153R and C417R impaired TLR and TNF-alpha induced NF-kappaB activation , L153R also increased *induced* [programmed cell death] with decreased A20 expression . Positive_regulation PDCD5 TNF 19706490 2144767 Expression of HO-1 suppresses the pro-oxidant effects of free heme , preventing it from sensitizing hepatocytes to undergo *mediated* [programmed cell death] by apoptosis . Positive_regulation PDCD5 TNF 20683023 2299016 Heterogeneity of radiation- and *induced* [programmed cell death] in carcinoma , sarcoma and lymphoma cell lines . Positive_regulation PDCD5 TNF 20705491 2312800 A20 is a ubiquitin modifying enzyme that restricts NF-kappaB signals and protects cells against *induced* [programmed cell death] . Positive_regulation PDCD5 TNF 20832854 2325321 It is thus suggested that the co-immobilized TNF-a plus IFN-? promotes the activation of some unknown key markers in response to IFN-? , and the binding of the co-immobilized plus IFN-? with some other TNF-a receptors *results* in enhanced [programmed cell death] in HeLa cells . Positive_regulation PDCD5 TNF 7593233 334622 Interferon-gamma and suppress both early and late stages of hematopoiesis and *induce* [programmed cell death] . Positive_regulation PDCD5 TNF 7600193 311514 The *induction* of accelerated thymic [programmed cell death] during polymicrobial sepsis : control by corticosteroids but not . Positive_regulation PDCD5 TNF 8166195 254832 *Induction* of [programmed cell death] ( apoptosis ) by was quantitated by means of a deoxyribonucleic acid fragmentation assay . Positive_regulation PDCD5 TNF 8627883 356112 Furthermore , by using a nuclease digestion assay , we demonstrated that *activated* a Ca++/Mg++ dependent endonuclease responsible for [programmed cell death] or apoptosis . Positive_regulation PDCD5 TNF 8657285 367011 Ceramide is an important regulatory participant of [programmed cell death] ( apoptosis ) *induced* by and Fas ligand , members of the TNF superfamily . Positive_regulation PDCD5 TNF 8670891 375089 Cathepsin D protease mediates [programmed cell death] *induced* by interferon-gamma , Fas/APO-1 and . Positive_regulation PDCD5 TNF 8670891 375103 Pepstatin A , an inhibitor of cathepsin D , suppressed cell death in these systems and interfered with the *induced* [programmed cell death] of U937 cells as well . Positive_regulation PDCD5 TNF 8758891 377826 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Positive_regulation PDCD5 TNF 9565035 500892 In adenovirus infected cells , [programmed cell death] ( apoptosis ) *induced* by the cytokine is inhibited by several adenovirus encoded proteins . Positive_regulation PDCD5 TNF 9602717 478290 Furthermore , *stimulates* [programmed cell death] ( apoptosis ) in luteal cells kept under culture conditions . Positive_regulation PDCD5 TNF 9806545 544823 We also found that Pml is essential for *induction* of [programmed cell death] by Fas , , ceramide and type I and II interferons ( IFNs ) . Positive_regulation PDCD5 TNFSF10 10960444 726376 Recombinant *induced* extensive [programmed cell death] in cholangiocarcinoma cell lines lacking decoy receptor expression . Positive_regulation PDCD5 TNFSF10 12398939 1008997 can selectively *induce* [programmed cell death] in transformed cells , although its wide tissue distribution suggests potential physiological roles . Positive_regulation PDCD5 TNFSF10 16251995 1525670 Using adenovirus ( Ad ) -mediated gene transfer , we overexpressed the proapoptotic molecules p53 , procaspase 3 , Bax , and to *induce* therapeutic [programmed cell death] of residual lens cells to prevent PCO . Positive_regulation PDCD5 TNFSF10 16651415 1557589 We propose that MNDA has a role regulating programmed cell death in myeloid progenitor cells , and that its down-regulation in MDS is related to granulocyte-macrophage progenitor cell sensitivity to *induced* [programmed cell death] . Positive_regulation PDCD5 TNFSF10 16934748 1608861 In conclusion , alternative splicing might be involved in functional fine tuning of *induced* [programmed cell death] . Positive_regulation PDCD5 TNFSF10 17487744 1739306 Thus , the effect of bexarotene on *mediated* [programmed cell death] involved proximal events of the extrinsic pathway ; Positive_regulation PDCD5 TNFSF10 19196465 2079382 Here , we hypothesise that the susceptibility of RASFs to receptor mediated apoptosis depends on the proliferation status of these cells and therefore analysed the cell cycle dependency of FasL- and *induced* [programmed cell death] of RASFs in vitro . Positive_regulation PDCD5 TNFSF10 21711324 2494354 The accumulation of apoptotic cell debris has been hypothesized to induce this autoimmune inflammation , and may *trigger* this [programmed cell death] . Positive_regulation PDCD5 TNFSF10 23792015 2824248 The accumulation of apoptotic cell debris has been hypothesized to induce the autoimmune inflammation in SLE , and may *trigger* this [programmed cell death] . Positive_regulation PDCD6 CAPN8 10825507 696698 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Positive_regulation PDCD6 CAPN8 18496573 1965557 ICP10PK inhibits *dependent* release of apoptosis inducing factor and [programmed cell death] in response to the toxin MPP+ . Positive_regulation PDCD6 CAPN8 20224428 2272733 Because beta3 integrin contributes to cardioprotective signaling , these studies indicate that the loss of specific integrin function could be a key mechanism for *mediated* [programmed cell death] of cardiomyocytes in PO myocardium . Positive_regulation PDCD6 CLU 22358960 178196 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Positive_regulation PDCD6 EPHB2 18713014 1974710 signaling *leads* to stimulus-specific changes in gene expression , alterations in cell metabolism or induction of [programmed cell death] ( apoptosis ) , and thus controls cell differentiation and proliferation . Positive_regulation PDCD6 FAS 10352248 617139 Restimulation of Ag receptors on peripheral T lymphocytes induces tyrosine phosphorylation based signaling cascades that evoke Fas ligand expression and induction of *mediated* [programmed cell death] . Positive_regulation PDCD6 FAS 10679090 668772 These results provide evidence that *mediated* [programmed cell death] plays a significant role in the pathogenesis of autoimmune diabetes . Positive_regulation PDCD6 FAS 10722700 677216 Activation of either tumor necrosis factor receptor 1 or *induces* a low level of [programmed cell death] in LNCaP human prostate cancer cells . Positive_regulation PDCD6 FAS 10726692 677727 Ceramides ( known stimuli of apoptosis downstream from the CD95-receptor complex ) also were used to test whether apoptosis would be induced in neuroblastoma cell cultures resistant to *mediated* [programmed cell death] . Positive_regulation PDCD6 FAS 11061245 746375 ( CD95 ) *triggers* [programmed cell death] and is involved in shutting off the immune response . Positive_regulation PDCD6 FAS 11164911 782702 The cellular caspase-inhibitory protein FLIP has been recently identified as a potent regulator of T lymphocyte susceptibility to *mediated* [programmed cell death] ( apoptosis ) . Positive_regulation PDCD6 FAS 11246866 793291 ( CD95 ) *triggers* [programmed cell death] and is involved in cell mediated cytotoxicity and in shutting off the immune response . Positive_regulation PDCD6 FAS 11342432 812725 Surprisingly , it was found that clonogenic progenitors were protected from gammaIFN plus *induced* [programmed cell death] when Lin ( + ) cells were removed from cultured splenocytes . Positive_regulation PDCD6 FAS 11385298 821655 ( CD95 ) and Fas ligand ( FasL/CD95L ) are *involved* in [programmed cell death] and the regulation of host immune responses . Positive_regulation PDCD6 FAS 11483955 844637 Here we have used a screen for proteins that interact physically with the cytoplasmic domain of the type II TGF-beta receptor to isolate the gene encoding Daxx - a protein associated with the Fas receptor that mediates activation of Jun amino-terminal kinase (JNK) and [programmed cell death] *induced* by . Positive_regulation PDCD6 FAS 1385299 200737 Binding of anti-APO-1 antibody to the *induces* [programmed cell death] ( apoptosis ) . Positive_regulation PDCD6 FAS 14977887 1227997 In fact , G1-overexpressing cells appeared resistant to both cytotoxic drug induced and *dependent* [programmed cell death] , and this resistance implicated mitochondrial apoptotic genes . Positive_regulation PDCD6 FAS 15879137 1406056 Heat killed A. phagocytophilum caused some similar initial alterations in neutrophil gene expression and function , which included delaying normal PMN apoptosis and blocking *induced* [programmed cell death] . Positive_regulation PDCD6 FAS 1689786 128399 Binding of to cells expressing APO-1 *results* in [programmed cell death] , apoptosis , the most common form of death in eukaryotic cells . Positive_regulation PDCD6 FAS 17605793 1774727 Molecular and biochemical assessment of these mutant Fas ligand proteins were carried out by expressing the mutant FasL cDNA in mammalian cells and analysis its effects on *mediated* [programmed cell death] . Positive_regulation PDCD6 FAS 22553782 2590586 However , PI3-K activation is crucial upon the BCR driven anti-apoptotic effect , while p38 MAPK mediated inactivation of caspases seems to play essential role in TLR9 mediated protection against *induced* [programmed cell death] . Positive_regulation PDCD6 FAS 7530337 291615 ( CD95 ) /FasL interactions *required* for [programmed cell death] after T-cell activation . Positive_regulation PDCD6 FAS 7896458 299843 In contrast to malignant cell lines , which express low levels of bax-alpha , non-malignant epithelial cell lines displaying high amounts of bax-alpha were highly sensitive to *induction* of [programmed cell death] by both serum starvation and ( CD95 ) triggering . Positive_regulation PDCD6 FAS 8647190 363434 While in most situations ligation *activates* [programmed cell death] , on resting T lymphocytes it can co-stimulate proliferation with the T cell receptor (TCR)/CD3 complex . Positive_regulation PDCD6 FAS 8670891 375093 Cathepsin D protease mediates [programmed cell death] *induced* by interferon-gamma , and TNF-alpha . Positive_regulation PDCD6 FAS 8758891 377829 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Positive_regulation PDCD6 FAS 8824295 385039 Genetic and pharmacological inhibition of Ras or Rac 1 and Rac 2 stimulation blocks Fas induced apoptosis , pointing to an important function of a Ras and Rac protein regulated signaling pathway in *mediated* [programmed cell death] . Positive_regulation PDCD6 FAS 8943716 400147 *induced* [programmed cell death] is mediated by a Ras regulated O2- synthesis . Positive_regulation PDCD6 FAS 8943716 400155 Likewise , the antioxidants N-acetyl-cysteine and N-t-butyl-phenylnitrone abolished Fas induced cell death , pointing to an important role for Ras triggered ROI synthesis in *mediated* [programmed cell death] . Positive_regulation PDCD6 FAS 8967952 402400 [Programmed cell death] ( apoptosis ) *mediated* by the cytokine receptor is critical for the removal of autoreactive T cells , the mechanism of immune privilege , and for maintenance of immune-system homeostasis . Positive_regulation PDCD6 FAS 9049148 416922 Reactive oxygen species ( ROS ) appear to be involved in *induced* [programmed cell death] . Positive_regulation PDCD6 FAS 9049787 416993 In contrast , rechallenge of previously stimulated lymphocytes with anti-CD3 monoclonal antibody triggered apoptosis in a larger proportion of T cells from cord blood as compared to peripheral blood , whereas the number of T cells undergoing *induced* [programmed cell death] were lower in cord blood compared to peripheral blood . Positive_regulation PDCD6 FAS 9064994 406209 The ( APO-1/Fas ) receptor *mediates* [programmed cell death] in apoptosis sensitive cells upon oligomerization either by CD95 antibody or by its natural ligand , CD95 ligand (CD95 L) . Positive_regulation PDCD6 FAS 9126929 426596 The interaction of ( CD95 ) , a member of the tumor necrosis factor receptor (TNFR) family , and its ligand ( FasL ) *triggers* [programmed cell death] ( apoptosis ) and is involved in the regulation of immune responses . Positive_regulation PDCD6 FAS 9177220 434112 In addition to providing costimulatory signals for cell proliferation , ligation of both TNFR1 and can *result* in [programmed cell death] or apoptosis . Positive_regulation PDCD6 FAS 9207149 440678 The n-type K+ channel ( n-K+ , Kv1.3 ) in lymphocytes has been recently implicated in the regulation of *induced* [programmed cell death] . Positive_regulation PDCD6 FAS 9207415 440828 CD40 and *induce* [programmed cell death] in the human myeloma cell line XG2 . Positive_regulation PDCD6 FAS 9208846 441001 ( CD95 ) ligation *activates* [programmed cell death] , a cellular process that plays an important role in the maturation of the host immune response . Positive_regulation PDCD6 FAS 9350288 460835 The mutation is leaky , allowing for low levels of the APO-1/Fas ( CD95 ) receptor and partial activity of ligand *mediated* [programmed cell death] in this strain . Positive_regulation PDCD6 FAS 9454753 484353 ) *triggers* [programmed cell death] after activation by its ligand and because incubation of human ECFCs with IFNgamma produces apoptosis , we have investigated the expression and function of Fas and Fas ligand (FasL) in highly purified human ECFCs before and after incubation with IFNgamma in vitro . Positive_regulation PDCD6 FAS 9490596 489558 [Programmed cell death] ( apoptosis ) *mediated* by ( CD95 ) , a 45-kD surface protein belonging to the tumor necrosis factor receptor family , is important in the resolution of all inflammatory immune responses . Positive_regulation PDCD6 FAS 9806545 544827 We also found that Pml is essential for *induction* of [programmed cell death] by , tumour necrosis factor alpha (TNF) , ceramide and type I and II interferons ( IFNs ) . Positive_regulation PDCD6 JAG1 16027528 1435888 Evaluation of biochemical and morphological features suggested that the major form of [programmed cell death] *induced* by 115 and EFDAC was autophagy . Positive_regulation PDCD6 MAP2K6 18713014 1974716 signaling *leads* to stimulus-specific changes in gene expression , alterations in cell metabolism or induction of [programmed cell death] ( apoptosis ) , and thus controls cell differentiation and proliferation . Positive_regulation PDCD6 TGM2 11697888 877666 activity is *involved* in polyamine induced [programmed cell death] . Positive_regulation PDCD6 TGM2 24778637 2937186 Senescence and [programmed cell death] in plants : polyamine action *mediated* by . Positive_regulation PDCD6 TNF 10657935 664298 Tumor necrosis factor (TNF) receptor ( TNFR ) -associated factors 1 and 2 ( TRAF1 and TRAF2 ) and inhibitor of apoptosis proteins cIAP1 ( MIHB ) and cIAP2 ( MIHC ) were recently identified as proteins that associate with the TNF-alpha receptors TNFRI ( p55 ) and TNFRII ( p75 ) and inhibit *induced* [programmed cell death] or apoptosis . Positive_regulation PDCD6 TNF 10858960 704757 These proteins are also known to interfere with [programmed cell death] *induced* by and Fas ligand . Positive_regulation PDCD6 TNF 11153078 759055 Since ceramide is an important regulatory molecule of [programmed cell death] *induced* by , we examined whether nef could alter TNF-alpha induced apoptosis in the U251MG human astrocytoma cell line . Positive_regulation PDCD6 TNF 12048203 968543 The activation of AKT2 inhibits UV- and TNF alpha induced c-Jun N-terminal kinase (JNK) and p38 activities that have been shown to be required for stress- and *induced* [programmed cell death] . Positive_regulation PDCD6 TNF 12048203 968551 Furthermore , phosphatidylinositol 3-kinase inhibitor or dominant negative AKT2 significantly enhances UV- and TNF alpha induced apoptosis , whereas expression of constitutively active AKT2 inhibits [programmed cell death] in *response* to UV and -induced apoptosis by inhibition of stress kinases and provide the first evidence that AKT inhibits stress kinase JNK through activation of the NF kappa B pathway . Positive_regulation PDCD6 TNF 12093867 960431 Fas and the *regulate* the [programmed cell death] of lymphocytes . Positive_regulation PDCD6 TNF 12446776 1017915 The proinflammatory cytokine *regulates* immune responses , inflammation , and [programmed cell death] ( apoptosis ) . Positive_regulation PDCD6 TNF 12933798 1151447 Zoledronate sensitizes endothelial cells to *induced* [programmed cell death] : evidence for the suppression of sustained activation of focal adhesion kinase and protein kinase B/Akt . Positive_regulation PDCD6 TNF 12933798 1151455 Taken together these data demonstrate that zoledronate sensitizes endothelial cells to *induced* , caspase independent [programmed cell death] and point to the FAK-PKB/Akt pathway as a novel zoledronate target . Positive_regulation PDCD6 TNF 14989423 1034264 IL-1 and TNFalpha share several biological properties but the salient difference is that receptor signaling *induces* [programmed cell death] whereas IL-1 receptor signaling does not . Positive_regulation PDCD6 TNF 15225801 1268425 Activation of p38 MAP kinase was shown to have both pro- and anti-apoptotic actions in *induced* [programmed cell death] depending on cell context . Positive_regulation PDCD6 TNF 15621052 1358408 *induces* [programmed cell death] and contributes to cardiac ischemia/reperfusion injury . Positive_regulation PDCD6 TNF 16077199 1442303 Apparently , cycloheximide sensitized cells to *induced* [programmed cell death] . Positive_regulation PDCD6 TNF 16083851 1442915 The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase independent [programmed cell death] *mediated* by . Positive_regulation PDCD6 TNF 18064605 1867947 We found that deoxycholyltaurine (DCT) markedly attenuated both unstimulated and *stimulated* [programmed cell death] in colon cancer cells by a phosphatidylinositol 3-kinase (PI3K) dependent mechanism . Positive_regulation PDCD6 TNF 18851874 2000879 Although both L153R and C417R impaired TLR and TNF-alpha induced NF-kappaB activation , L153R also increased *induced* [programmed cell death] with decreased A20 expression . Positive_regulation PDCD6 TNF 19706490 2144768 Expression of HO-1 suppresses the pro-oxidant effects of free heme , preventing it from sensitizing hepatocytes to undergo *mediated* [programmed cell death] by apoptosis . Positive_regulation PDCD6 TNF 20683023 2299017 Heterogeneity of radiation- and *induced* [programmed cell death] in carcinoma , sarcoma and lymphoma cell lines . Positive_regulation PDCD6 TNF 20705491 2312801 A20 is a ubiquitin modifying enzyme that restricts NF-kappaB signals and protects cells against *induced* [programmed cell death] . Positive_regulation PDCD6 TNF 20832854 2325322 It is thus suggested that the co-immobilized TNF-a plus IFN-? promotes the activation of some unknown key markers in response to IFN-? , and the binding of the co-immobilized plus IFN-? with some other TNF-a receptors *results* in enhanced [programmed cell death] in HeLa cells . Positive_regulation PDCD6 TNF 7593233 334624 Interferon-gamma and suppress both early and late stages of hematopoiesis and *induce* [programmed cell death] . Positive_regulation PDCD6 TNF 7600193 311515 The *induction* of accelerated thymic [programmed cell death] during polymicrobial sepsis : control by corticosteroids but not . Positive_regulation PDCD6 TNF 8166195 254833 *Induction* of [programmed cell death] ( apoptosis ) by was quantitated by means of a deoxyribonucleic acid fragmentation assay . Positive_regulation PDCD6 TNF 8627883 356113 Furthermore , by using a nuclease digestion assay , we demonstrated that *activated* a Ca++/Mg++ dependent endonuclease responsible for [programmed cell death] or apoptosis . Positive_regulation PDCD6 TNF 8657285 367013 Ceramide is an important regulatory participant of [programmed cell death] ( apoptosis ) *induced* by and Fas ligand , members of the TNF superfamily . Positive_regulation PDCD6 TNF 8670891 375092 Cathepsin D protease mediates [programmed cell death] *induced* by interferon-gamma , Fas/APO-1 and . Positive_regulation PDCD6 TNF 8670891 375104 Pepstatin A , an inhibitor of cathepsin D , suppressed cell death in these systems and interfered with the *induced* [programmed cell death] of U937 cells as well . Positive_regulation PDCD6 TNF 8758891 377828 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Positive_regulation PDCD6 TNF 9565035 500893 In adenovirus infected cells , [programmed cell death] ( apoptosis ) *induced* by the cytokine is inhibited by several adenovirus encoded proteins . Positive_regulation PDCD6 TNF 9602717 478291 Furthermore , *stimulates* [programmed cell death] ( apoptosis ) in luteal cells kept under culture conditions . Positive_regulation PDCD6 TNF 9806545 544826 We also found that Pml is essential for *induction* of [programmed cell death] by Fas , , ceramide and type I and II interferons ( IFNs ) . Positive_regulation PDCD6 TNFSF10 10960444 726377 Recombinant *induced* extensive [programmed cell death] in cholangiocarcinoma cell lines lacking decoy receptor expression . Positive_regulation PDCD6 TNFSF10 12398939 1008998 can selectively *induce* [programmed cell death] in transformed cells , although its wide tissue distribution suggests potential physiological roles . Positive_regulation PDCD6 TNFSF10 16251995 1525672 Using adenovirus ( Ad ) -mediated gene transfer , we overexpressed the proapoptotic molecules p53 , procaspase 3 , Bax , and to *induce* therapeutic [programmed cell death] of residual lens cells to prevent PCO . Positive_regulation PDCD6 TNFSF10 16651415 1557590 We propose that MNDA has a role regulating programmed cell death in myeloid progenitor cells , and that its down-regulation in MDS is related to granulocyte-macrophage progenitor cell sensitivity to *induced* [programmed cell death] . Positive_regulation PDCD6 TNFSF10 16934748 1608862 In conclusion , alternative splicing might be involved in functional fine tuning of *induced* [programmed cell death] . Positive_regulation PDCD6 TNFSF10 17487744 1739307 Thus , the effect of bexarotene on *mediated* [programmed cell death] involved proximal events of the extrinsic pathway ; Positive_regulation PDCD6 TNFSF10 19196465 2079383 Here , we hypothesise that the susceptibility of RASFs to receptor mediated apoptosis depends on the proliferation status of these cells and therefore analysed the cell cycle dependency of FasL- and *induced* [programmed cell death] of RASFs in vitro . Positive_regulation PDCD6 TNFSF10 21711324 2494355 The accumulation of apoptotic cell debris has been hypothesized to induce this autoimmune inflammation , and may *trigger* this [programmed cell death] . Positive_regulation PDCD6 TNFSF10 23792015 2824249 The accumulation of apoptotic cell debris has been hypothesized to induce the autoimmune inflammation in SLE , and may *trigger* this [programmed cell death] . Positive_regulation PDCD7 CAPN8 10825507 696712 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Positive_regulation PDCD7 CAPN8 18496573 1965572 ICP10PK inhibits *dependent* release of apoptosis inducing factor and [programmed cell death] in response to the toxin MPP+ . Positive_regulation PDCD7 CAPN8 20224428 2272747 Because beta3 integrin contributes to cardioprotective signaling , these studies indicate that the loss of specific integrin function could be a key mechanism for *mediated* [programmed cell death] of cardiomyocytes in PO myocardium . Positive_regulation PDCD7 CLU 22358960 178197 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Positive_regulation PDCD7 EPHB2 18713014 1974718 signaling *leads* to stimulus-specific changes in gene expression , alterations in cell metabolism or induction of [programmed cell death] ( apoptosis ) , and thus controls cell differentiation and proliferation . Positive_regulation PDCD7 FAS 10352248 617140 Restimulation of Ag receptors on peripheral T lymphocytes induces tyrosine phosphorylation based signaling cascades that evoke Fas ligand expression and induction of *mediated* [programmed cell death] . Positive_regulation PDCD7 FAS 10679090 668774 These results provide evidence that *mediated* [programmed cell death] plays a significant role in the pathogenesis of autoimmune diabetes . Positive_regulation PDCD7 FAS 10722700 677218 Activation of either tumor necrosis factor receptor 1 or *induces* a low level of [programmed cell death] in LNCaP human prostate cancer cells . Positive_regulation PDCD7 FAS 10726692 677728 Ceramides ( known stimuli of apoptosis downstream from the CD95-receptor complex ) also were used to test whether apoptosis would be induced in neuroblastoma cell cultures resistant to *mediated* [programmed cell death] . Positive_regulation PDCD7 FAS 11061245 746376 ( CD95 ) *triggers* [programmed cell death] and is involved in shutting off the immune response . Positive_regulation PDCD7 FAS 11164911 782703 The cellular caspase-inhibitory protein FLIP has been recently identified as a potent regulator of T lymphocyte susceptibility to *mediated* [programmed cell death] ( apoptosis ) . Positive_regulation PDCD7 FAS 11246866 793292 ( CD95 ) *triggers* [programmed cell death] and is involved in cell mediated cytotoxicity and in shutting off the immune response . Positive_regulation PDCD7 FAS 11342432 812726 Surprisingly , it was found that clonogenic progenitors were protected from gammaIFN plus *induced* [programmed cell death] when Lin ( + ) cells were removed from cultured splenocytes . Positive_regulation PDCD7 FAS 11385298 821657 ( CD95 ) and Fas ligand ( FasL/CD95L ) are *involved* in [programmed cell death] and the regulation of host immune responses . Positive_regulation PDCD7 FAS 11483955 844638 Here we have used a screen for proteins that interact physically with the cytoplasmic domain of the type II TGF-beta receptor to isolate the gene encoding Daxx - a protein associated with the Fas receptor that mediates activation of Jun amino-terminal kinase (JNK) and [programmed cell death] *induced* by . Positive_regulation PDCD7 FAS 1385299 200738 Binding of anti-APO-1 antibody to the *induces* [programmed cell death] ( apoptosis ) . Positive_regulation PDCD7 FAS 14977887 1227998 In fact , G1-overexpressing cells appeared resistant to both cytotoxic drug induced and *dependent* [programmed cell death] , and this resistance implicated mitochondrial apoptotic genes . Positive_regulation PDCD7 FAS 15879137 1406057 Heat killed A. phagocytophilum caused some similar initial alterations in neutrophil gene expression and function , which included delaying normal PMN apoptosis and blocking *induced* [programmed cell death] . Positive_regulation PDCD7 FAS 1689786 128400 Binding of to cells expressing APO-1 *results* in [programmed cell death] , apoptosis , the most common form of death in eukaryotic cells . Positive_regulation PDCD7 FAS 17605793 1774728 Molecular and biochemical assessment of these mutant Fas ligand proteins were carried out by expressing the mutant FasL cDNA in mammalian cells and analysis its effects on *mediated* [programmed cell death] . Positive_regulation PDCD7 FAS 22553782 2590587 However , PI3-K activation is crucial upon the BCR driven anti-apoptotic effect , while p38 MAPK mediated inactivation of caspases seems to play essential role in TLR9 mediated protection against *induced* [programmed cell death] . Positive_regulation PDCD7 FAS 7530337 291617 ( CD95 ) /FasL interactions *required* for [programmed cell death] after T-cell activation . Positive_regulation PDCD7 FAS 7896458 299844 In contrast to malignant cell lines , which express low levels of bax-alpha , non-malignant epithelial cell lines displaying high amounts of bax-alpha were highly sensitive to *induction* of [programmed cell death] by both serum starvation and ( CD95 ) triggering . Positive_regulation PDCD7 FAS 8647190 363435 While in most situations ligation *activates* [programmed cell death] , on resting T lymphocytes it can co-stimulate proliferation with the T cell receptor (TCR)/CD3 complex . Positive_regulation PDCD7 FAS 8670891 375096 Cathepsin D protease mediates [programmed cell death] *induced* by interferon-gamma , and TNF-alpha . Positive_regulation PDCD7 FAS 8758891 377831 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Positive_regulation PDCD7 FAS 8824295 385040 Genetic and pharmacological inhibition of Ras or Rac 1 and Rac 2 stimulation blocks Fas induced apoptosis , pointing to an important function of a Ras and Rac protein regulated signaling pathway in *mediated* [programmed cell death] . Positive_regulation PDCD7 FAS 8943716 400148 *induced* [programmed cell death] is mediated by a Ras regulated O2- synthesis . Positive_regulation PDCD7 FAS 8943716 400156 Likewise , the antioxidants N-acetyl-cysteine and N-t-butyl-phenylnitrone abolished Fas induced cell death , pointing to an important role for Ras triggered ROI synthesis in *mediated* [programmed cell death] . Positive_regulation PDCD7 FAS 8967952 402401 [Programmed cell death] ( apoptosis ) *mediated* by the cytokine receptor is critical for the removal of autoreactive T cells , the mechanism of immune privilege , and for maintenance of immune-system homeostasis . Positive_regulation PDCD7 FAS 9049148 416923 Reactive oxygen species ( ROS ) appear to be involved in *induced* [programmed cell death] . Positive_regulation PDCD7 FAS 9049787 416994 In contrast , rechallenge of previously stimulated lymphocytes with anti-CD3 monoclonal antibody triggered apoptosis in a larger proportion of T cells from cord blood as compared to peripheral blood , whereas the number of T cells undergoing *induced* [programmed cell death] were lower in cord blood compared to peripheral blood . Positive_regulation PDCD7 FAS 9064994 406210 The ( APO-1/Fas ) receptor *mediates* [programmed cell death] in apoptosis sensitive cells upon oligomerization either by CD95 antibody or by its natural ligand , CD95 ligand (CD95 L) . Positive_regulation PDCD7 FAS 9126929 426597 The interaction of ( CD95 ) , a member of the tumor necrosis factor receptor (TNFR) family , and its ligand ( FasL ) *triggers* [programmed cell death] ( apoptosis ) and is involved in the regulation of immune responses . Positive_regulation PDCD7 FAS 9177220 434114 In addition to providing costimulatory signals for cell proliferation , ligation of both TNFR1 and can *result* in [programmed cell death] or apoptosis . Positive_regulation PDCD7 FAS 9207149 440679 The n-type K+ channel ( n-K+ , Kv1.3 ) in lymphocytes has been recently implicated in the regulation of *induced* [programmed cell death] . Positive_regulation PDCD7 FAS 9207415 440830 CD40 and *induce* [programmed cell death] in the human myeloma cell line XG2 . Positive_regulation PDCD7 FAS 9208846 441002 ( CD95 ) ligation *activates* [programmed cell death] , a cellular process that plays an important role in the maturation of the host immune response . Positive_regulation PDCD7 FAS 9350288 460837 The mutation is leaky , allowing for low levels of the APO-1/Fas ( CD95 ) receptor and partial activity of ligand *mediated* [programmed cell death] in this strain . Positive_regulation PDCD7 FAS 9454753 484354 ) *triggers* [programmed cell death] after activation by its ligand and because incubation of human ECFCs with IFNgamma produces apoptosis , we have investigated the expression and function of Fas and Fas ligand (FasL) in highly purified human ECFCs before and after incubation with IFNgamma in vitro . Positive_regulation PDCD7 FAS 9490596 489559 [Programmed cell death] ( apoptosis ) *mediated* by ( CD95 ) , a 45-kD surface protein belonging to the tumor necrosis factor receptor family , is important in the resolution of all inflammatory immune responses . Positive_regulation PDCD7 FAS 9806545 544830 We also found that Pml is essential for *induction* of [programmed cell death] by , tumour necrosis factor alpha (TNF) , ceramide and type I and II interferons ( IFNs ) . Positive_regulation PDCD7 JAG1 16027528 1435889 Evaluation of biochemical and morphological features suggested that the major form of [programmed cell death] *induced* by 115 and EFDAC was autophagy . Positive_regulation PDCD7 MAP2K6 18713014 1974724 signaling *leads* to stimulus-specific changes in gene expression , alterations in cell metabolism or induction of [programmed cell death] ( apoptosis ) , and thus controls cell differentiation and proliferation . Positive_regulation PDCD7 TGM2 11697888 877673 activity is *involved* in polyamine induced [programmed cell death] . Positive_regulation PDCD7 TGM2 24778637 2937193 Senescence and [programmed cell death] in plants : polyamine action *mediated* by . Positive_regulation PDCD7 TNF 10657935 664299 Tumor necrosis factor (TNF) receptor ( TNFR ) -associated factors 1 and 2 ( TRAF1 and TRAF2 ) and inhibitor of apoptosis proteins cIAP1 ( MIHB ) and cIAP2 ( MIHC ) were recently identified as proteins that associate with the TNF-alpha receptors TNFRI ( p55 ) and TNFRII ( p75 ) and inhibit *induced* [programmed cell death] or apoptosis . Positive_regulation PDCD7 TNF 10858960 704759 These proteins are also known to interfere with [programmed cell death] *induced* by and Fas ligand . Positive_regulation PDCD7 TNF 11153078 759056 Since ceramide is an important regulatory molecule of [programmed cell death] *induced* by , we examined whether nef could alter TNF-alpha induced apoptosis in the U251MG human astrocytoma cell line . Positive_regulation PDCD7 TNF 12048203 968544 The activation of AKT2 inhibits UV- and TNF alpha induced c-Jun N-terminal kinase (JNK) and p38 activities that have been shown to be required for stress- and *induced* [programmed cell death] . Positive_regulation PDCD7 TNF 12048203 968552 Furthermore , phosphatidylinositol 3-kinase inhibitor or dominant negative AKT2 significantly enhances UV- and TNF alpha induced apoptosis , whereas expression of constitutively active AKT2 inhibits [programmed cell death] in *response* to UV and -induced apoptosis by inhibition of stress kinases and provide the first evidence that AKT inhibits stress kinase JNK through activation of the NF kappa B pathway . Positive_regulation PDCD7 TNF 12093867 960432 Fas and the *regulate* the [programmed cell death] of lymphocytes . Positive_regulation PDCD7 TNF 12446776 1017916 The proinflammatory cytokine *regulates* immune responses , inflammation , and [programmed cell death] ( apoptosis ) . Positive_regulation PDCD7 TNF 12933798 1151448 Zoledronate sensitizes endothelial cells to *induced* [programmed cell death] : evidence for the suppression of sustained activation of focal adhesion kinase and protein kinase B/Akt . Positive_regulation PDCD7 TNF 12933798 1151456 Taken together these data demonstrate that zoledronate sensitizes endothelial cells to *induced* , caspase independent [programmed cell death] and point to the FAK-PKB/Akt pathway as a novel zoledronate target . Positive_regulation PDCD7 TNF 14989423 1034265 IL-1 and TNFalpha share several biological properties but the salient difference is that receptor signaling *induces* [programmed cell death] whereas IL-1 receptor signaling does not . Positive_regulation PDCD7 TNF 15225801 1268426 Activation of p38 MAP kinase was shown to have both pro- and anti-apoptotic actions in *induced* [programmed cell death] depending on cell context . Positive_regulation PDCD7 TNF 15621052 1358409 *induces* [programmed cell death] and contributes to cardiac ischemia/reperfusion injury . Positive_regulation PDCD7 TNF 16077199 1442304 Apparently , cycloheximide sensitized cells to *induced* [programmed cell death] . Positive_regulation PDCD7 TNF 16083851 1442916 The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase independent [programmed cell death] *mediated* by . Positive_regulation PDCD7 TNF 18064605 1867948 We found that deoxycholyltaurine (DCT) markedly attenuated both unstimulated and *stimulated* [programmed cell death] in colon cancer cells by a phosphatidylinositol 3-kinase (PI3K) dependent mechanism . Positive_regulation PDCD7 TNF 18851874 2000880 Although both L153R and C417R impaired TLR and TNF-alpha induced NF-kappaB activation , L153R also increased *induced* [programmed cell death] with decreased A20 expression . Positive_regulation PDCD7 TNF 19706490 2144769 Expression of HO-1 suppresses the pro-oxidant effects of free heme , preventing it from sensitizing hepatocytes to undergo *mediated* [programmed cell death] by apoptosis . Positive_regulation PDCD7 TNF 20683023 2299018 Heterogeneity of radiation- and *induced* [programmed cell death] in carcinoma , sarcoma and lymphoma cell lines . Positive_regulation PDCD7 TNF 20705491 2312802 A20 is a ubiquitin modifying enzyme that restricts NF-kappaB signals and protects cells against *induced* [programmed cell death] . Positive_regulation PDCD7 TNF 20832854 2325323 It is thus suggested that the co-immobilized TNF-a plus IFN-? promotes the activation of some unknown key markers in response to IFN-? , and the binding of the co-immobilized plus IFN-? with some other TNF-a receptors *results* in enhanced [programmed cell death] in HeLa cells . Positive_regulation PDCD7 TNF 7593233 334626 Interferon-gamma and suppress both early and late stages of hematopoiesis and *induce* [programmed cell death] . Positive_regulation PDCD7 TNF 7600193 311516 The *induction* of accelerated thymic [programmed cell death] during polymicrobial sepsis : control by corticosteroids but not . Positive_regulation PDCD7 TNF 8166195 254834 *Induction* of [programmed cell death] ( apoptosis ) by was quantitated by means of a deoxyribonucleic acid fragmentation assay . Positive_regulation PDCD7 TNF 8627883 356114 Furthermore , by using a nuclease digestion assay , we demonstrated that *activated* a Ca++/Mg++ dependent endonuclease responsible for [programmed cell death] or apoptosis . Positive_regulation PDCD7 TNF 8657285 367015 Ceramide is an important regulatory participant of [programmed cell death] ( apoptosis ) *induced* by and Fas ligand , members of the TNF superfamily . Positive_regulation PDCD7 TNF 8670891 375095 Cathepsin D protease mediates [programmed cell death] *induced* by interferon-gamma , Fas/APO-1 and . Positive_regulation PDCD7 TNF 8670891 375105 Pepstatin A , an inhibitor of cathepsin D , suppressed cell death in these systems and interfered with the *induced* [programmed cell death] of U937 cells as well . Positive_regulation PDCD7 TNF 8758891 377830 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Positive_regulation PDCD7 TNF 9565035 500894 In adenovirus infected cells , [programmed cell death] ( apoptosis ) *induced* by the cytokine is inhibited by several adenovirus encoded proteins . Positive_regulation PDCD7 TNF 9602717 478292 Furthermore , *stimulates* [programmed cell death] ( apoptosis ) in luteal cells kept under culture conditions . Positive_regulation PDCD7 TNF 9806545 544829 We also found that Pml is essential for *induction* of [programmed cell death] by Fas , , ceramide and type I and II interferons ( IFNs ) . Positive_regulation PDCD7 TNFSF10 10960444 726378 Recombinant *induced* extensive [programmed cell death] in cholangiocarcinoma cell lines lacking decoy receptor expression . Positive_regulation PDCD7 TNFSF10 12398939 1008999 can selectively *induce* [programmed cell death] in transformed cells , although its wide tissue distribution suggests potential physiological roles . Positive_regulation PDCD7 TNFSF10 16251995 1525674 Using adenovirus ( Ad ) -mediated gene transfer , we overexpressed the proapoptotic molecules p53 , procaspase 3 , Bax , and to *induce* therapeutic [programmed cell death] of residual lens cells to prevent PCO . Positive_regulation PDCD7 TNFSF10 16651415 1557591 We propose that MNDA has a role regulating programmed cell death in myeloid progenitor cells , and that its down-regulation in MDS is related to granulocyte-macrophage progenitor cell sensitivity to *induced* [programmed cell death] . Positive_regulation PDCD7 TNFSF10 16934748 1608863 In conclusion , alternative splicing might be involved in functional fine tuning of *induced* [programmed cell death] . Positive_regulation PDCD7 TNFSF10 17487744 1739308 Thus , the effect of bexarotene on *mediated* [programmed cell death] involved proximal events of the extrinsic pathway ; Positive_regulation PDCD7 TNFSF10 19196465 2079384 Here , we hypothesise that the susceptibility of RASFs to receptor mediated apoptosis depends on the proliferation status of these cells and therefore analysed the cell cycle dependency of FasL- and *induced* [programmed cell death] of RASFs in vitro . Positive_regulation PDCD7 TNFSF10 21711324 2494356 The accumulation of apoptotic cell debris has been hypothesized to induce this autoimmune inflammation , and may *trigger* this [programmed cell death] . Positive_regulation PDCD7 TNFSF10 23792015 2824250 The accumulation of apoptotic cell debris has been hypothesized to induce the autoimmune inflammation in SLE , and may *trigger* this [programmed cell death] . Positive_regulation PDE4B CREB1 12065634 954526 Dominant negative mutants of CREB suppressed [PDE4B2] promoter activity and a constitutively active form of robustly *stimulated* it . Positive_regulation PDE4B CREB3 12065634 954527 Dominant negative mutants of CREB suppressed [PDE4B2] promoter activity and a constitutively active form of robustly *stimulated* it . Positive_regulation PDE4B CREB5 12065634 954525 Dominant negative mutants of CREB suppressed [PDE4B2] promoter activity and a constitutively active form of robustly *stimulated* it . Positive_regulation PDE4B PDE4D 11476896 841936 Stimulation for 24 h by TSH , forskolin or dibutyryl cAMP *induced* an increase in mRNA levels of [PDE4B] , , and PDE4C . Positive_regulation PDE4B PRKACB 16458997 1567526 Despite the hypoxia induced increases in the expression of PDE4A10/11 , [PDE4B2] and PDE4D5 and *activation* of certain of these long PDE4 isoforms through phosphorylation , we suggest that the failure to see any overall increase in PDE4 activity is due to ERK mediated phosphorylation and inhibition of particular PDE4 long isoforms . Positive_regulation PDE4B PRKACB 24413164 2917778 ß1AR- but not ß2AR-ligation induced dependent *activation* of [PDE4B] and interruption of this negative feedback with PKA inhibitors increased sarcolemmal cAMP . Positive_regulation PDE4B PRKACG 16458997 1567527 Despite the hypoxia induced increases in the expression of PDE4A10/11 , [PDE4B2] and PDE4D5 and *activation* of certain of these long PDE4 isoforms through phosphorylation , we suggest that the failure to see any overall increase in PDE4 activity is due to ERK mediated phosphorylation and inhibition of particular PDE4 long isoforms . Positive_regulation PDE4B PRKACG 24413164 2917779 ß1AR- but not ß2AR-ligation induced dependent *activation* of [PDE4B] and interruption of this negative feedback with PKA inhibitors increased sarcolemmal cAMP . Positive_regulation PDE4B PRKAR1A 16458997 1567528 Despite the hypoxia induced increases in the expression of PDE4A10/11 , [PDE4B2] and PDE4D5 and *activation* of certain of these long PDE4 isoforms through phosphorylation , we suggest that the failure to see any overall increase in PDE4 activity is due to ERK mediated phosphorylation and inhibition of particular PDE4 long isoforms . Positive_regulation PDE4B PRKAR1A 24413164 2917780 ß1AR- but not ß2AR-ligation induced dependent *activation* of [PDE4B] and interruption of this negative feedback with PKA inhibitors increased sarcolemmal cAMP . Positive_regulation PDE4B PRKAR1B 16458997 1567529 Despite the hypoxia induced increases in the expression of PDE4A10/11 , [PDE4B2] and PDE4D5 and *activation* of certain of these long PDE4 isoforms through phosphorylation , we suggest that the failure to see any overall increase in PDE4 activity is due to ERK mediated phosphorylation and inhibition of particular PDE4 long isoforms . Positive_regulation PDE4B PRKAR1B 24413164 2917781 ß1AR- but not ß2AR-ligation induced dependent *activation* of [PDE4B] and interruption of this negative feedback with PKA inhibitors increased sarcolemmal cAMP . Positive_regulation PDE4B PRKAR2A 16458997 1567530 Despite the hypoxia induced increases in the expression of PDE4A10/11 , [PDE4B2] and PDE4D5 and *activation* of certain of these long PDE4 isoforms through phosphorylation , we suggest that the failure to see any overall increase in PDE4 activity is due to ERK mediated phosphorylation and inhibition of particular PDE4 long isoforms . Positive_regulation PDE4B PRKAR2A 24413164 2917782 ß1AR- but not ß2AR-ligation induced dependent *activation* of [PDE4B] and interruption of this negative feedback with PKA inhibitors increased sarcolemmal cAMP . Positive_regulation PDE4B PRKAR2B 16458997 1567531 Despite the hypoxia induced increases in the expression of PDE4A10/11 , [PDE4B2] and PDE4D5 and *activation* of certain of these long PDE4 isoforms through phosphorylation , we suggest that the failure to see any overall increase in PDE4 activity is due to ERK mediated phosphorylation and inhibition of particular PDE4 long isoforms . Positive_regulation PDE4B PRKAR2B 24413164 2917783 ß1AR- but not ß2AR-ligation induced dependent *activation* of [PDE4B] and interruption of this negative feedback with PKA inhibitors increased sarcolemmal cAMP . Positive_regulation PDE4B TLR1 16034090 1436246 In these cells , LPS stimulation of *caused* a major up-regulation of [PDE4B] but not the paralogs PDE4A or PDE4D . Positive_regulation PDE4B TLR10 16034090 1436254 In these cells , LPS stimulation of *caused* a major up-regulation of [PDE4B] but not the paralogs PDE4A or PDE4D . Positive_regulation PDE4B TLR2 16034090 1436247 In these cells , LPS stimulation of *caused* a major up-regulation of [PDE4B] but not the paralogs PDE4A or PDE4D . Positive_regulation PDE4B TLR3 16034090 1436248 In these cells , LPS stimulation of *caused* a major up-regulation of [PDE4B] but not the paralogs PDE4A or PDE4D . Positive_regulation PDE4B TLR4 16034090 1436249 In these cells , LPS stimulation of *caused* a major up-regulation of [PDE4B] but not the paralogs PDE4A or PDE4D . Positive_regulation PDE4B TLR5 16034090 1436250 In these cells , LPS stimulation of *caused* a major up-regulation of [PDE4B] but not the paralogs PDE4A or PDE4D . Positive_regulation PDE4B TLR6 16034090 1436255 In these cells , LPS stimulation of *caused* a major up-regulation of [PDE4B] but not the paralogs PDE4A or PDE4D . Positive_regulation PDE4B TLR7 16034090 1436251 In these cells , LPS stimulation of *caused* a major up-regulation of [PDE4B] but not the paralogs PDE4A or PDE4D . Positive_regulation PDE4B TLR8 16034090 1436252 In these cells , LPS stimulation of *caused* a major up-regulation of [PDE4B] but not the paralogs PDE4A or PDE4D . Positive_regulation PDE4B TLR9 16034090 1436253 In these cells , LPS stimulation of *caused* a major up-regulation of [PDE4B] but not the paralogs PDE4A or PDE4D . Positive_regulation PDE4B TNF 22865690 2687455 Immunoblotting for PDE4 showed that both cytokines increased PDE4A1 , but only *increased* [PDE4B2] . Positive_regulation PDE4D EPHB2 10187850 602988 In addition , we show that stimulation of PKC via the associated activation of the cascade results in the phosphorylation and *activation* of [PDE4D3] in these cells . Positive_regulation PDE4D MAP2K6 10187850 602994 In addition , we show that stimulation of PKC via the associated activation of the cascade results in the phosphorylation and *activation* of [PDE4D3] in these cells . Positive_regulation PDE5A ANGPT2 15623434 1358487 rapidly and transiently *increased* [PDE5A] mRNA levels in rat aortic VSMC . Positive_regulation PDE5A ANGPT2 15623434 1358488 Increased [PDE5A] mRNA level was transcription dependent and *mediated* by the type 1 receptor . Positive_regulation PDE5A ANGPT2 15623434 1358489 activation of extracellular signal regulated kinases 1/2 ( ERK1/2 ) was *essential* for Ang II-induced [PDE5A] upregulation . Positive_regulation PDE5A BRAF 24710960 2938895 Recent studies have shown that activation down-regulates PDE5A levels , and low [PDE5A] expression by BRAF activation or sildenafil use *increases* the invasiveness of melanoma cells , which raises the possible adverse effect of sildenafil use on melanoma risk . Positive_regulation PDE5A NPPA 17906676 1824255 [PDE-5A] is rapidly activated in *response* to stimulation and lowers intracellular cGMP levels . Positive_regulation PDE7A STK39 17558395 1762790 We show that a , PpkA , is *required* for assembly of the H-T6SS and for secretion of [Hcp1] . Positive_regulation PDGFA F2R 11861803 917355 We characterized the relationship between CD62 expression and platelet derived growth factor ( [PDGF)(AB] ) and PDGF(BB) secretion in *response* to activating peptide ( TRAP ) . Positive_regulation PDGFA F2R 17958740 1814933 The agonist peptide *had* no effect on cell growth and [PDGF-AB] levels . Positive_regulation PDGFA F2R 8607120 342735 activating peptide ( TRAP ) *stimulates* mitogenesis , c-fos and [PDGF-A] gene expression in human vascular smooth muscle cells . Positive_regulation PDGFA HBEGF 20172951 2360209 Whereas LPS did not increase expression of VEGF , angiopoietin-1 (Ang-1) , Tie2 , fetal liver kinase-1 (Flk-1) , fms-like tyrosine kinase-1 (Flt-1) , [PDGFA] , PDGFB , ( HB-EGF ) , or connective tissue growth factor (CTGF) , LPS did *stimulate* the production of the angiogenic CC chemokines macrophage inflammatory protein-1a ( MIP-1a ) and monocyte chemoattractant protein-1 ( MCP-1 ) . Positive_regulation PDGFA IL1B 1995295 154270 *stimulates* [PDGF-AA] synthesis also in the presence of indomethacin , a prostaglandin synthesis inhibitor . Positive_regulation PDGFA IL1B 1995295 154271 Transforming growth factor beta 1 ( TGF-beta 1 ) , a dimeric polypeptide which displays multiple biological activities , inhibits in a dose dependent manner ( 1-10 ng/ml ) [PDGF-AA] production *induced* by . Positive_regulation PDGFA MAP2K6 15920755 1497524 [PDGF-AB] *induced* a rapid activation followed by phosphorylation of the MEK substrates ERK1/2 while FGF-2 showed a less pronounced and delayed activation . Positive_regulation PDGFA TNF 10412737 630862 Exposure to VLDL , IDL , LDL , or a high concentration of HDL *enhanced* the secretion of IL-6 , [PDGF-AB] , and TGF-beta by mesangial cells , whereas secretion was stimulated by oxidized LDL . Positive_regulation PDGFA TNF 7673548 325963 Prostaglandin E1 slightly inhibited PDGF-AB production , transforming growth factor beta 1 *promoted* [PDGF-AB] production and interferon-gamma , interleukin-1 alpha , and failed to exert any influence at all . Positive_regulation PDGFA TNF 7751646 306774 *induces* [PDGF A] chain gene expression with a maximum at 4 h. DNA synthesis is abrogated in response to TNF-alpha by a goat anti-PDGF IgG but not by nonimmune goat IgG , suggesting induction of an autocrine PDGF-AA loop by TNF-alpha . Positive_regulation PDGFB CCND1 17823285 1801962 [PDGF-BB] *induced* expression , CDK4 activity , and Rb protein phosphorylation , leading to VSMC growth and motility , and these responses were suppressed by the blockade of STAT-5B . Positive_regulation PDGFB CCND1 23637826 2779267 These effects of extract were due to blockade of [PDGF-BB] *induced* expression of iNOS , and proliferating cell nuclear antigen ( PCNA ) . Positive_regulation PDGFB CCND1 8831499 385736 [PDGF-BB] *induced* an increase in mRNA levels of , cyclin dependent kinase (cdk) 4 , and cdk2 , as well as the activity of cdk2 , which preceded the G1/S boundary , as estimated by the kinetics of DNA synthesis . Positive_regulation PDGFB CTGF 22363445 2561523 induced PDGF-B expression in endothelial cells , and *potentiated* [PDGF-B] mediated Akt signaling in mural ( vascular smooth muscle/pericyte ) cells . Positive_regulation PDGFB EPHB2 15948243 1421111 [PDGF-BB] *induced* STAT-specific binding activity , and activation of Src , JAK2 , STAT1 , STAT3 , and . Positive_regulation PDGFB EPHB2 19417143 2179775 Imatinib ( 1 µmol/L ) treatment of DAOY and D556 cells inhibited PDGF-BB- and serum mediated migration and invasion at 24 and 48 h , respectively , and concomitantly inhibited [PDGF-BB] *activation* of PDGFRB , Akt , and but increased PTEN expression and activity . Positive_regulation PDGFB F2R 11861803 917356 We characterized the relationship between CD62 expression and platelet derived growth factor ( [PDGF)(AB] ) and PDGF(BB) secretion in *response* to activating peptide ( TRAP ) . Positive_regulation PDGFB F2R 17958740 1814934 The agonist peptide *had* no effect on cell growth and [PDGF-AB] levels . Positive_regulation PDGFB IL1B 12200971 982985 The effect of IL-1 beta on syndecan-1 mRNA synthesis was partially reversed after adding [PDGF-BB] and TGF-beta 1 , separately or in combination , in the *presence* of . Positive_regulation PDGFB IL1B 8627292 355862 [PDGF B-chain] mRNA levels were *increased* by TGF-beta 1 , TNF-alpha , TNF-alpha/TGF-beta , or 1 , whereas PDGF A-chain mRNA levels were not consistently affected by cytokine treatments . Positive_regulation PDGFB IL1B 9284956 451877 Expression of KGF transcript was down-regulated by EGF , TGF-alpha , and [PDGF-BB] , was markedly *up-regulated* by , and was more pronounced in limbal than in corneal fibroblasts . Positive_regulation PDGFB ITGB2 19728062 2175871 Additionally , blockade significantly *inhibited* the [Ang-2/PDGF-BB] based increase in matrix metalloproteinase-9 (MMP-9) and membrane type-1-MMP (MT1-MMP) . Positive_regulation PDGFB MAP2K6 15920755 1497531 [PDGF-AB] *induced* a rapid activation followed by phosphorylation of the MEK substrates ERK1/2 while FGF-2 showed a less pronounced and delayed activation . Positive_regulation PDGFB MMP28 18489818 1939190 So , [PDGF-B] may *induce* the expression of for the degradation of collagen type III on the wall of the saccular aneurysms . Positive_regulation PDGFB MMP28 20392987 2240433 Additionally , blockade *down-regulated* VEGF-A and up-regulated [PDGF-BB] . Positive_regulation PDGFB MMP7 18489818 1939205 So , [PDGF-B] may *induce* the expression of for the degradation of collagen type III on the wall of the saccular aneurysms . Positive_regulation PDGFB MMP7 20392987 2240448 Additionally , blockade *down-regulated* VEGF-A and up-regulated [PDGF-BB] . Positive_regulation PDGFB TNF 10412737 630864 Exposure to VLDL , IDL , LDL , or a high concentration of HDL *enhanced* the secretion of IL-6 , [PDGF-AB] , and TGF-beta by mesangial cells , whereas secretion was stimulated by oxidized LDL . Positive_regulation PDGFB TNF 12730063 1106748 Functional studies confirmed the senescent dysregulation of TNF-alpha receptor pathways , demonstrating that *induced* [PDGF-B] expression in cardiac microvascular endothelial cells of 4-mo-old , but not 24-mo-old , rats . Positive_regulation PDGFB TNF 15175554 1254916 In the present study , by using the antioxidant N-acetylcysteine (NAC) , we investigated in human umbilical vein endothelial cells ( HUVECs ) the roles of oxidative stress in [PDGF-B] expression *induced* by and its underlying mechanisms . Positive_regulation PDGFB TNF 15175554 1254924 These results suggest that oxidative stress mediates the *induced* expression of [PDGF-B] in HUVECs through redox-sensitive transcription factors , predominantly the SP-1 and possibly , to some extent of NF-kappaB . Positive_regulation PDGFB TNF 23664275 2796060 By using pharmacological inhibitors , specific for the main pathways , NF-kB , ERK1/2 and p38 MAPK , activated by exposure of endothelial cells to TNF-a , we found that only NF-kB appeared to be significantly involved in mediating the [PDGF-BB] *induction* by . Positive_regulation PDGFB TNF 7673548 325967 Prostaglandin E1 slightly inhibited PDGF-AB production , transforming growth factor beta 1 *promoted* [PDGF-AB] production and interferon-gamma , interleukin-1 alpha , and failed to exert any influence at all . Positive_regulation PDGFB TNF 8627292 355861 [PDGF B-chain] mRNA levels were *increased* by TGF-beta 1 , , TNF-alpha/TGF-beta , or IL-1-beta/TGF-beta 1 , whereas PDGF A-chain mRNA levels were not consistently affected by cytokine treatments . Positive_regulation PDGFC EPHB2 15247255 1295844 Fibroblast growth factor-2 induction of [platelet derived growth factor-C] chain transcription in vascular smooth muscle cells is *dependent* but not JNK dependent and mediated by Egr-1 . Positive_regulation PDGFC EPHB2 15247255 1295855 Moreover , using pharmacological inhibitors we demonstrate the critical *role* of but not JNK in FGF-2-inducible [PDGF-C] expression . Positive_regulation PDGFC EPHB2 15247255 1295859 These findings thus demonstrate that [PDGF-C] transcription , activated by FGF-2 , is *mediated* by Egr-1 and its upstream kinase . Positive_regulation PDGFC EPHB2 19795151 2209073 PD98059 , a specific inhibitor of phosphorylation , but not the p38 inhibitor SB203580 or the JNK inhibitor SP600125 *prevented* [PDGF-CC] induced TF expression in a concentration dependent manner . Positive_regulation PDGFC PLAT 15372073 1297785 is a potent *activator* of [PDGF-CC] . Positive_regulation PDGFC PLAT 15372073 1297786 We further demonstrate that growth of primary fibroblasts in culture is dependent on a *mediated* cleavage of latent [PDGF-CC] , generating a growth stimulatory loop . Positive_regulation PDGFC PLAT 15911618 1433296 Recently , the multidomain serine protease , a thrombolytic agent used for treatment of acute ischemic stroke , was shown to cleave and *activate* [PDGF-CC] . Positive_regulation PDGFC PLAT 15911618 1433297 In this study we determine the molecular mechanism of *mediated* activation of [PDGF-CC] . Positive_regulation PDGFC PLAT 15911618 1433299 Elucidating the regulation and the mechanism of *mediated* activation of [PDGF-CC] will advance our knowledge of the physiological function of PDGF-CC and tPA and may provide new therapeutic opportunities for thrombolytic and cardiovascular therapies . Positive_regulation PDGFC PLAT 18568034 1934997 *Activation* of [PDGF-CC] by impairs blood-brain barrier integrity during ischemic stroke . Positive_regulation PDGFC PLAT 24269585 2898281 is not *necessary* for [platelet derived growth factor-c] activation . Positive_regulation PDGFD PLAU 15988036 1429275 [Platelet derived growth factor D] is *activated* by in prostate carcinoma cells . Positive_regulation PDGFD PLAU 18997817 2028972 Here , we elucidate the structural requirements for *mediated* activation of [PDGF-DD] , as well as the intricate interplay with uPA receptor (uPAR) signalling . Positive_regulation PDGFRA IL1B 10030841 591882 Because *upregulates* both PGE2 production and [PDGF-Ralpha] expression , these data suggest that PGE2 functions in a negative feedback loop to limit expression of PDGF-Ralpha and suppress PDGF stimulated myofibroblast proliferation . Positive_regulation PDGFRA IL1B 19648113 2143246 IL-1beta facilitates the dissociation of histone deacetylase (HDAC)-1/2 from the PDGF-R alpha promoter , whereas the HDAC inhibitors suberoylanilide hydroxamic acid and trichostatin A potentiate *induction* of [PDGF-R alpha] transcription . Positive_regulation PDGFRA IL1B 8760137 378023 We previously reported that *upregulates* the PDGF receptor-alpha ( [PDGFR-alpha] ) gene , and in this study we sought to establish the importance of the PDGFR-alpha relative to the PDGFR-beta in mediating a chemotactic response to PDGF-AA , -AB , and -BB . Positive_regulation PDGFRA IL1B 9458803 484640 These data suggest that *mediated* induction of [PDGF-R alpha] in vivo is important to lung myofibroblast hyperplasia during fibrogenesis . Positive_regulation PDGFRA IL1B 9759865 536576 Treatment of cells with pyrrolidine dithiocarbamate ( PDTC ) , an antioxidant that inhibits NF-kappaB activation , completely blocked [PDGF-Ralpha] *up-regulation* by as assayed by [ 125I ] PDGF-AA binding and PDGF-Ralpha mRNA expression , suggesting a role for NF-kappaB . Positive_regulation PDGFRA IL1B 9759865 536590 Pretreatment of cells with the MAP kinase kinase-1 (MEK1) inhibitor PD 98059 blocked IL-1beta induced activation of ERK-2 by more than 90 % but enhanced *stimulated* induction of [PDGF-Ralpha] expression fourfold . Positive_regulation PDGFRB EPHB2 14657000 1202049 We investigated this crosstalk under different conditions and found that both Akt and activation induced by S1P , but not lysophosphatidic acid (LPA) , in HEY ovarian cancer cells *required* [PDGFR] but not epidermal growth factor receptor (EGFR) or insulin-like growth factor-I receptor ( IGFR ) . Positive_regulation PDGFRB IL1B 16477012 1554860 *induced* a sustained phosphorylation of [PDGF receptor (PDGFR)-beta] and its association with IL-1 receptor ( IL-1R1 ) . Positive_regulation PDGFRB IL1B 17299794 1718842 Src , PDGFR , and PI3K/Akt mediated the effects of IL-1beta because pretreatment with PP1 , AG1296 , and wortmannin also abrogated *stimulated* Src , [PDGFR] , and Akt phosphorylation , respectively . Positive_regulation PDGFRB IL1B 18315570 1897522 *stimulated* c-Src , [PDGFR] , and Akt phosphorylation and proMMP-9 expression were attenuated by the inhibitors of c-Src ( PP1 ) , PDGFR ( AG1296 ) , and PI3K ( LY294002 ) , respectively , or transfection with dominant negative plasmid of c-Src or short hairpin RNAs of PDGFR and Akt . Positive_regulation PDGFRB TNF 24361597 2911233 Moreover , also time-dependently *stimulated* phosphorylation of c-Src and PDGFR and [c-Src/PDGFR] complex formation , which were reduced by pretreatment with PP1 or AG1296 . Positive_regulation PDHX FOXO1 23045346 2706500 We previously reported that statin myopathy is associated with impaired carbohydrate ( CHO ) oxidation in fast-twitch rodent skeletal muscle , which we hypothesised occurred as a result of *mediated* upregulation of [pyruvate dehydrogenase kinase-4 (PDK4)] gene transcription . Positive_regulation PDHX FOXO1 23247844 2745670 *mediated* upregulation of [pyruvate dehydrogenase kinase-4 (PDK4)] decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension : therapeutic benefits of dichloroacetate . Positive_regulation PDK1 CAPN8 23071514 2685987 Pro-death activity of violacein is actually carried out by inhibition of and DAPK1 and *activation* of PKA , AKT and [PDK] , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation PDK1 DAPK1 23071514 2685991 Pro-death activity of violacein is actually carried out by inhibition of calpain and and *activation* of PKA , AKT and [PDK] , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation PDK2 CAPN8 23071514 2686002 Pro-death activity of violacein is actually carried out by inhibition of and DAPK1 and *activation* of PKA , AKT and [PDK] , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation PDK2 DAPK1 23071514 2686006 Pro-death activity of violacein is actually carried out by inhibition of calpain and and *activation* of PKA , AKT and [PDK] , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation PDK3 CAPN8 23071514 2686017 Pro-death activity of violacein is actually carried out by inhibition of and DAPK1 and *activation* of PKA , AKT and [PDK] , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation PDK3 DAPK1 23071514 2686021 Pro-death activity of violacein is actually carried out by inhibition of calpain and and *activation* of PKA , AKT and [PDK] , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation PDK4 CAPN8 23071514 2686032 Pro-death activity of violacein is actually carried out by inhibition of and DAPK1 and *activation* of PKA , AKT and [PDK] , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation PDK4 DAPK1 23071514 2686036 Pro-death activity of violacein is actually carried out by inhibition of calpain and and *activation* of PKA , AKT and [PDK] , followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse , leading to cellular demise . Positive_regulation PDK4 FOXO1 17079227 1654917 The forkhead transcription factor ( ) binds the PDK4 gene and *contributes* to the induction of [PDK4] by ERRs and PGC-1alpha . Positive_regulation PDK4 FOXO1 23247844 2745671 Chronic dichloroacetate inhibits *induced* [PDK4] upregulation and restores GO , leading to improved bioenergetics and RV function in RVH . Positive_regulation PDLIM7 CAPN8 18363826 1925384 A cell-permeant specific inhibitor of ( PD150606 ) *prevented* [LMP] , but not ROS production . Positive_regulation PDLIM7 CCL17 14747532 1204352 Collectively , [LMP1] *induces* and CCL22 in EBV infected B cells via activation of NF-kappa B and probably ATF2 . Positive_regulation PDLIM7 CCND1 24499623 2884900 These findings may provide a novel linkage between the EGFR and STAT3 signaling pathways and the *activation* of by [LMP1] in the carcinogenesis of NPC . Positive_regulation PDLIM7 FAS 19664329 2119345 As a nuclear factor-kappaB (NF-kappaB) dependent molecule , is *induced* by [LMP1] , and LMP1 enhances Fas mediated apoptosis , according to our finding of stimulus dependent apoptosis regulation by LMP1 . Positive_regulation PDLIM7 HBEGF 17361012 1777666 Epidermal growth factor receptor (EGFR) ligands ( transforming growth factor alpha ( TGFalpha ) , and epiregulin ) are constitutively *induced* by [LMP1] , leading to EGFR phosphorylation but also down-regulation , degradation or turn-over , with the appearance of cleaved EGFR fragments . Positive_regulation PDLIM7 ID1 21701587 2447041 interacts and *stabilizes* the Epstein-Barr virus [latent membrane protein 1 (LMP1)] in nasopharyngeal epithelial cells . Positive_regulation PDLIM7 ITGB2 2157887 131495 [LMP1] expression in all cell lines *induced* growth in large clumps and expression of the cellular adhesion molecules ICAM-1 , , and LFA-3 in those cell lines which constitutively express low levels . Positive_regulation PDLIM7 ITGB2 8093369 210044 [LMP1] also *induced* increased CD21 , ICAM-1 and surface expression on transfected primary T-cells , and CD21 and ICAM-1 in four of five B-cell chronic lymphocytic leukemias tested . Positive_regulation PDLIM7 MAP2K6 18363826 1925372 Both [LMP] and ROS production were *blocked* by an NMDA channel blocker ( MK-801 ) and by inhibitors of ( U0126 ) , calcium dependent/independent phospholipases A2 ( methyl arachidonyl fluorophosphonate ) but not calcium independent phospholipases A2 ( bromoenol lactone ) and cyclooxygenase-2 ( NS398 ) . Positive_regulation PDLIM7 TLR7 22952664 2667449 We find that activation *increases* the expression of EBV [LMP1] , and IFN regulatory factor 7 (IRF7) is involved in the stimulation process . Positive_regulation PDLIM7 TLR7 22952664 2667454 Therefore , the aberrant activation of might *induce* [LMP1] expression and LMP1-expression cells may be producing IFNs in lupus patients . Positive_regulation PDLIM7 TNF 18056442 1833578 Similar to that of LAPF silencing , silencing of endogenous p53 expression in L929 cells could significantly impair *induced* [LMP] and apoptosis . Positive_regulation PDLIM7 TNF 22454477 2594949 *induced* [LMP] is effectively abrogated by siRNAs targeting acid sphingomyelinase or acid ceramidase , which prevent both LMP and death induced by TNF/CHX . Positive_regulation PDLIM7 TNF 9205097 440478 Epstein-Barr virus encoded [LMP1] and CD40 mediate IL-6 production in epithelial cells via an NF-kappaB pathway *involving* receptor associated factors . Positive_regulation PDLIM7 TNFAIP2 23975427 2942270 Luciferase reporter assays showed that [LMP1] transcriptionally *induces* expression through a newly identified NF-?B binding site within the TNFAIP2 promoter ( -3,869 to -3,860 bp ) . Positive_regulation PDR PLAT 25349789 2959845 To investigate the *role* of and plasminogen activator inhibitor (PAI) in [proliferative diabetic retinopathy (PDR)] and to discuss the correlations among t-PA , PAI and vascular endothelial growth factor ( VEGF ) expressions . Positive_regulation PDX1 FOXO1 16282329 1509485 Taken together , is *involved* in the nucleocytoplasmic translocation of [PDX-1] by oxidative stress and the JNK pathway . Positive_regulation PDYN EPHB2 11784793 901082 MAP kinase activation in superficial spinal cord neurons *induces* [prodynorphin] and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity . Positive_regulation PDZK1 PDZK1IP1 12837682 1134685 Results obtained from transfection studies using opossum kidney cells indicated that the apical localization of MAP17 is independent of PDZK1 but that is *required* for apical localization of [PDZK1] . Positive_regulation PDZK1 PPARA 18955051 1989319 Finally , we demonstrate that endogenous *regulates* [PDZK1] expression . Positive_regulation PDZK1 SCARB1 23720744 2806798 Immunohistochemical studies established that the localization of [PDZK1] on hepatocyte cell surface membranes in vivo is *dependent* on its PDZ4 domain and the presence of . Positive_regulation PEA15 EDN2 9721757 528745 *induces* a calcium dependent phosphorylation of [PEA-15] in intact astrocytes : identification of Ser104 and Ser116 phosphorylated , respectively , by protein kinase C and calcium/calmodulin kinase II in vitro . Positive_regulation PEA15 EDN2 9721757 528750 These results demonstrate that [PEA-15] is phosphorylated in astrocytes by CaMKII ( or a related kinase ) and by protein kinase C in *response* to . Positive_regulation PEBP1 ABCA4 21554544 2470212 One hypothesis suggests that *mediates* the trans-bilayer translocation of [retinal-phosphatidylethanolamine] conjugates to facilitate the retinal regeneration process in the visual cycle . Positive_regulation PEBP1 TNF 8808758 382945 *had* no effect on the distribution of radioactivity in 1-acyl , 1-alkyl , and 1-alk-1-enyl subclasses of phosphatidylcholine , [phosphatidylethanolamine] , and triglyceride . Positive_regulation PEBP4 ABCA4 21554544 2470211 One hypothesis suggests that *mediates* the trans-bilayer translocation of [retinal-phosphatidylethanolamine] conjugates to facilitate the retinal regeneration process in the visual cycle . Positive_regulation PEBP4 TNF 8808758 382944 *had* no effect on the distribution of radioactivity in 1-acyl , 1-alkyl , and 1-alk-1-enyl subclasses of phosphatidylcholine , [phosphatidylethanolamine] , and triglyceride . Positive_regulation PECAM1 AKT1 23292117 2742042 EGCG inhibited HPV-16 oncoprotein induced angiogenesis conferred by NSCLC through the inhibition of HIF-1a protein expression and HIF-1a dependent expression of VEGF , IL-8 , and [CD31] as well as *activation* of , suggesting that HIF-1a may be a potential target of EGCG against HPV related NSCLC angiogenesis . Positive_regulation PECAM1 AKT2 23292117 2742043 EGCG inhibited HPV-16 oncoprotein induced angiogenesis conferred by NSCLC through the inhibition of HIF-1a protein expression and HIF-1a dependent expression of VEGF , IL-8 , and [CD31] as well as *activation* of , suggesting that HIF-1a may be a potential target of EGCG against HPV related NSCLC angiogenesis . Positive_regulation PECAM1 AKT3 23292117 2742044 EGCG inhibited HPV-16 oncoprotein induced angiogenesis conferred by NSCLC through the inhibition of HIF-1a protein expression and HIF-1a dependent expression of VEGF , IL-8 , and [CD31] as well as *activation* of , suggesting that HIF-1a may be a potential target of EGCG against HPV related NSCLC angiogenesis . Positive_regulation PECAM1 ANGPT1 22558265 2591220 Overexpression of *led* to significant increases in number of [CD31] ( + ) and smooth muscle-like cells and VEGF expression in bone marrow ( BM ) . Positive_regulation PECAM1 APOB 12775720 1119807 Together , these findings suggest that , following a first phase in which LDL , through its B-site , phosphorylates and thereby activates p38MAPK , a second phase is initiated in which *activates* [PECAM-1] and induces dephosphorylation of p38MAPK via activation of the Ser/Thr phosphatases PP1/PP2A . Positive_regulation PECAM1 APOB 23956504 2831859 Expressions of ICAM-1 , [PECAM-1] , and VCAM-1 as well as the levels of intracellular Ca ( 2+ ) are also markedly *increased* by in a dose dependent manner . Positive_regulation PECAM1 BDKRB2 18672896 1948191 Coexpression of , a Galphaq/11 coupled receptor , with PECAM-1 *enhances* formation of the [PECAM-1-Galphaq/11] complex , suggesting an interaction between PECAM-1 and BKRB2 . Positive_regulation PECAM1 CCL2 22641100 2632594 Surface localization of [PECAM-1] is increased in *response* to . Positive_regulation PECAM1 CDC73 12709415 1093365 The activated *increased* the mucosal IL-6 and [PECAM-1] , enhanced the expression of FasL but not Fas , and led to the cleavage of Bid and the release of cytochrome c from mitochondria to activate caspase-9 . Positive_regulation PECAM1 CDH5 17170064 1717050 Endothelial stimulation of ASCs in methylcellulose elicits phenotypic changes , marginal upregulation of CD31 , and expression and restrictive *induction* of a [CD31] ( + ) CD144 ( + ) immunophenotype . Positive_regulation PECAM1 CRP 11520795 852349 Stimulation of platelets by collagen- , ( GP)VI-selective agonist , , and PECAM-1-immunoglobulin chimera *induced* tyrosine phosphorylation of [PECAM-1] in a time- and dose dependent manner . Positive_regulation PECAM1 CSF1 11895768 920769 The M-CSF receptor was expressed in PCLP1 ( + ) CD45 ( - ) cells , the precursors of endothelial cells , and *up-regulated* the expression of more mature endothelial cell markers-VCAM-1 , [PECAM-1] , and E-selectin-in PCLP1 ( + ) CD45 ( - ) cells . Positive_regulation PECAM1 CTR9 12709415 1093366 The activated *increased* the mucosal IL-6 and [PECAM-1] , enhanced the expression of FasL but not Fas , and led to the cleavage of Bid and the release of cytochrome c from mitochondria to activate caspase-9 . Positive_regulation PECAM1 CXCL12 22121892 2636414 Functional assays showed that activation of this receptor by stimulated the migration of LSEC and *increased* the expression of [PECAM-1] . Positive_regulation PECAM1 DNTT 11948141 930085 Double-immunofluorescent IHC for *mediated* dUTP-biotin nick-end labeling ( TUNEL ) and [CD-31] demonstrated tumor and endothelial cell apoptosis in those tumors treated with Ad-hIFN-beta gene therapy . Positive_regulation PECAM1 DNTT 24976986 2947623 In parallel , lungs were removed and Colocalization with *mediated* dUTP nick end labeling ( TUNEL ) , Hoeschts and [CD31] was performed to evaluate pulmonary capillaries-specific apoptosis and identify the origins of the EMPs . Positive_regulation PECAM1 ENG 21406632 2416501 By using region of interest ( ROI ) analysis , the DOS measure of total tissue hemoglobin ( Hb ( T ) ) was temporally correlated with quantitative measures of existing ( [CD31] expressing ) and tumor *induced* ( expressing ) vessels , in pretreatment and posttreatment tissue specimens , to assess change . Positive_regulation PECAM1 FGF1 19080715 2003357 In the *presence* of VEGF and , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 FGF10 19080715 2003358 In the *presence* of VEGF and , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 FGF11 19080715 2003359 In the *presence* of VEGF and , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 FGF12 19080715 2003360 In the *presence* of VEGF and , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 FGF13 19080715 2003361 In the *presence* of VEGF and , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 FGF14 19080715 2003362 In the *presence* of VEGF and , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 FGF16 19080715 2003363 In the *presence* of VEGF and , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 FGF17 19080715 2003364 In the *presence* of VEGF and , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 FGF18 19080715 2003365 In the *presence* of VEGF and , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 FGF19 19080715 2003366 In the *presence* of VEGF and , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 FGF2 19080715 2003367 In the *presence* of VEGF and , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 FGF20 19080715 2003368 In the *presence* of VEGF and , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 FGF21 19080715 2003369 In the *presence* of VEGF and , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 FGF22 19080715 2003370 In the *presence* of VEGF and , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 FGF23 19080715 2003371 In the *presence* of VEGF and , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 FGF3 19080715 2003372 In the *presence* of VEGF and , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 FGF4 19080715 2003373 In the *presence* of VEGF and , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 FGF5 19080715 2003374 In the *presence* of VEGF and , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 FGF6 19080715 2003375 In the *presence* of VEGF and , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 FGF7 19080715 2003376 In the *presence* of VEGF and , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 FGF8 19080715 2003377 In the *presence* of VEGF and , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 FGF9 19080715 2003378 In the *presence* of VEGF and , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 HLA-DRA 11899433 894258 The results show that exposure to LPG did not affect the expression of major histocompatibility complex ( and B7 , but *induced* an up-regulation of CD25 , [CD31] and vascular endothelial (VE)-cadherin expression and a down-regulation of Mac-1 expression , by LC . Positive_regulation PECAM1 HLA-DRB1 11899433 894259 The results show that exposure to LPG did not affect the expression of major histocompatibility complex ( and B7 , but *induced* an up-regulation of CD25 , [CD31] and vascular endothelial (VE)-cadherin expression and a down-regulation of Mac-1 expression , by LC . Positive_regulation PECAM1 HMOX1 17488882 1766627 In conclusion , and eNOS are relevant targets for D-4F and may *contribute* to the D-4F mediated increase in TM and [CD31] ( + ) , the antioxidant and anti-inflammatory properties , and confers robust vascular protection in this animal model of type 1 diabetes . Positive_regulation PECAM1 ICAM1 22806890 2660204 Importantly , *induction* of Src signaling induced [PECAM-1] Tyr686 phosphorylation and increased EC surface anti-PECAM-1 mAb binding activity . Positive_regulation PECAM1 IFNB1 11781384 900333 Treatment with LPS and triggering of the endothelial cells with PECAM-1 mAb or recombinant PECAM-1 had no effect on gelatinase A or B production , whereas PMA stimulated the production of progelatinase B . significantly *up-regulated* the expression of [PECAM-1] in HUVECs but did not affect gelatinase secretion . Positive_regulation PECAM1 IGF1 18939362 1978036 Combination of 20 ng/ml TNF-alpha with 50 ng/ml IGF-1 enhances expression of CD54 to 96.8 +/- 1.2 % , with 200 ng/ml *enhances* [CD31] and CD54 expression respectively to 90.5 +/- 2.3 % and 96.6 +/- 0.6 % . Positive_regulation PECAM1 IL17A 23372655 2739170 Inhibition of at tumor sites significantly *suppressed* [CD31] , MMP9 , and VEGF expression in tumor tissue . Positive_regulation PECAM1 IL3 12935294 1157806 We have identified the inhibitory immunoreceptor PECAM-1 ( platelet endothelial cell adhesion molecule-1 ) /CD31 ( cluster determinant 31 ) as a component of this 135 kDa substrate and also show that can *induce* tyrosine phosphorylation of [PECAM-1] . Positive_regulation PECAM1 IL4 10804726 691944 Interleukin-7 preserved the population of CD4+CD31- T cells in cord blood and induced their IL-4 producing ability without T cell receptor ( TCR ) stimulation , while *induced* [CD31] on CD31- T cells and could not induce their IL-4 producing ability . Positive_regulation PECAM1 IL7 19008454 2047184 Furthermore , sustained or *increased* [CD31] expression even in nonproliferating cells . Positive_regulation PECAM1 IL9 23335955 2733743 also *promoted* angiogenesis and VEGF and [CD31] overexpression in mice in vivo and increased tube formation of human endothelial cells in vitro . Positive_regulation PECAM1 INS 15133755 1245760 Neutrophil-transendothelial migration and [PECAM-1] expression were *enhanced* by ( 100 micro U/mL , 24 h ) and were attenuated by gliclazide ( 20 micro M ) , but not by other K ( ATP ) channel blockers ( glibenclamide , nateglinide , and glimepiride ) . Positive_regulation PECAM1 ITGAV 10438720 635000 These results indicate that CD31 mediated inside-out signaling activates on endothelial cells , that the heterophilic alphavbeta3 [integrin/CD31] interaction *induces* beta1 integrin mediated adhesion of eosinophils to endothelial cells , and that the heterophilic interaction itself is not significantly involved in firm adhesion of eosinophils to endothelial cells . Positive_regulation PECAM1 ITGB3 10438720 635001 These results indicate that CD31 mediated inside-out signaling activates on endothelial cells , that the heterophilic alphavbeta3 [integrin/CD31] interaction *induces* beta1 integrin mediated adhesion of eosinophils to endothelial cells , and that the heterophilic interaction itself is not significantly involved in firm adhesion of eosinophils to endothelial cells . Positive_regulation PECAM1 LEO1 12709415 1093369 The activated *increased* the mucosal IL-6 and [PECAM-1] , enhanced the expression of FasL but not Fas , and led to the cleavage of Bid and the release of cytochrome c from mitochondria to activate caspase-9 . Positive_regulation PECAM1 LYN 21297004 2410369 was *required* for [PECAM-1] tyrosine phosphorylation and subsequent binding of the Src homology 2 domain containing phosphatase-2 , SHP-2 . Positive_regulation PECAM1 MBTPS1 18502612 1928185 In this study , we demonstrated that *induced* [PECAM-1] tyrosine phosphorylation in human umbilical cord vein cells ( HUVECs ) . Positive_regulation PECAM1 MBTPS1 18502612 1928186 Moreover , cSrc and Fyn siRNA significantly suppressed *induced* [PECAM-1] phosphorylation . Positive_regulation PECAM1 MBTPS1 18502612 1928187 These results suggested that *induced* [PECAM-1] phosphorylation through G ( i ) and subsequent cSrc and Fyn . Positive_regulation PECAM1 NEU1 24550400 2928893 overexpression *increased* [CD31] binding to Arachis hypogaea or peanut agglutinin lectin , indicating CD31 desialylation . Positive_regulation PECAM1 NFKB1 10640752 660660 These results demonstrate that can *regulate* the transcriptional activity of [PECAM-1] . Positive_regulation PECAM1 NOS3 17488882 1766628 In conclusion , HO-1 and are relevant targets for D-4F and may *contribute* to the D-4F mediated increase in TM and [CD31] ( + ) , the antioxidant and anti-inflammatory properties , and confers robust vascular protection in this animal model of type 1 diabetes . Positive_regulation PECAM1 NOTCH1 22865639 2687441 ß ( 2 ) -Integrin and differentially *regulate* CD34 ( + ) [CD31] ( + ) cell plasticity in vascular niches . Positive_regulation PECAM1 OSM 17218396 1717769 These cells expressed CD49f but not CD45 , CD34 , Thy-1 , c-kit , [CD31] , or flk-1 , and *induced* their differentiation . Positive_regulation PECAM1 PAF1 12709415 1093367 The activated *increased* the mucosal IL-6 and [PECAM-1] , enhanced the expression of FasL but not Fas , and led to the cleavage of Bid and the release of cytochrome c from mitochondria to activate caspase-9 . Positive_regulation PECAM1 PMP2 11583705 865770 stimulation of THP-1 cells *increased* CD11b , CD32 , and CD33 but not CD29 , [CD31] , and CD36 . Positive_regulation PECAM1 PMP22 11583705 865771 stimulation of THP-1 cells *increased* CD11b , CD32 , and CD33 but not CD29 , [CD31] , and CD36 . Positive_regulation PECAM1 PPP1R3A 20473743 2258033 Panaxoside could *increase* the expression of HIF-1alpha and [CD31] of myocardium and stimulate the angiogenesis . Positive_regulation PECAM1 PTPN11 12535670 1049642 Using differentially phosphorylated recombinant proteins we found that phosphotyrosine 686 preferentially mediates binding and 663 mediates *activation* of by [PECAM-1] . Positive_regulation PECAM1 PTPN11 19096001 2036193 These findings reveal that p38MAPK phosphorylation and platelet activation by LDL are suppressed by two mechanisms : ( 1 ) short *activation* of [PECAM-1/PP2A] , and ( 2 ) prolonged activation of SHP-1 and . Positive_regulation PECAM1 PTPN6 19096001 2036194 These findings reveal that p38MAPK phosphorylation and platelet activation by LDL are suppressed by two mechanisms : ( 1 ) short activation of [PECAM-1/PP2A] , and ( 2 ) prolonged *activation* of and SHP-2 . Positive_regulation PECAM1 RELA 10640752 660661 These results demonstrate that can *regulate* the transcriptional activity of [PECAM-1] . Positive_regulation PECAM1 RETN 19445973 2120293 In endothelial EA.hy 926 cells , *increased* the expression of MCP-1 and [PECAM-1] and adhesion of monocytes to endothelial cells . Positive_regulation PECAM1 SELE 9506571 491441 In early lesions , expression of [PECAM-1] , ICAM-1 , ICAM-2 , and P-selectin was similar to that in control samples , and VCAM-1 and were *induced* in vascular endothelium . Positive_regulation PECAM1 SETD2 23292117 2742041 EGCG inhibited HPV-16 oncoprotein induced angiogenesis conferred by NSCLC through the inhibition of HIF-1a protein expression and *dependent* expression of VEGF , IL-8 , and [CD31] as well as activation of Akt , suggesting that HIF-1a may be a potential target of EGCG against HPV related NSCLC angiogenesis . Positive_regulation PECAM1 SRC 12775720 1119777 Interestingly , LDL and the B-site peptide also *induce* tyrosine phosphorylation of [PECAM-1] , and studies with immunoprecipitates indicate the involvement of . Positive_regulation PECAM1 TAT 23301033 2725846 In an allograft model , *promotes* vIL-6 induced tumorigenesis and expression of [CD31] , CD34 , SMA , VEGF , b-FGF , and cyclin D1 . Positive_regulation PECAM1 TGFB1 7930623 274765 Analysis of the intracellular signaling pathways indicates that *induces* protein kinase C activity , as well as [PECAM-1] phosphorylation and association with cytoskeletal components . Positive_regulation PECAM1 TGFB3 16323168 1490902 In tandem , *increased* the level of expression of both Flk-1 and [CD31] . Positive_regulation PECAM1 TIE1 12107087 963013 Relative to control , in dermis highly stimulated by VEGF , the Ang-2 mRNA transcript numbers increased 35-fold , [PECAM-1] and VE-cadherin increased 10-fold , *increased* 8-fold , KDR and Flt-1 each increased 4-fold , and Ang-1 increased 2-fold . Positive_regulation PECAM1 TLR4 12091428 960148 These findings demonstrate that endotoxin induced keratitis is regulated by *dependent* expression of [PECAM-1] and MIP-2 , which are essential for recruitment of neutrophils to this site and for development of endotoxin induced stromal disease . Positive_regulation PECAM1 TNF 10484438 644096 The dual radiolabeled monoclonal antibody technique was used to quantify constitutive and *induced* expression of intercellular adhesion molecule 1 ( ICAM-1 ) , vascular cell adhesion molecule 1 ( VCAM-1 ) , ICAM-2 , P-selectin , E-selectin , and platelet-endothelial cell adhesion molecule 1 ( [PECAM-1] ) in different vascular beds of normal ( C57Bl/6 ) and RM-1 tumor bearing mice . Positive_regulation PECAM1 TNF 10996391 733874 Early production of after liver injury could *induce* an increased ICAM-1-expression and a decreased [PECAM-1] expression , which might be essential for the transmigration of inflammatory cells into the parenchyma . Positive_regulation PECAM1 TNF 15969490 1423821 Immunocytochemical staining showed that methoxyflavone modestly inhibited [PECAM-1] expression *induced* by . Positive_regulation PECAM1 TNF 16916501 1672901 Niacin reduced TNF-alpha induced rise in ICAM-1 levels by 66 % to 89 % ( p < 0.0001 ) , but did not significantly affect *induced* rise in [PECAM-1] . Positive_regulation PECAM1 TNF 17259331 1691247 Additionally , immunocytochemical staining revealed that isoliquiritigenin attenuated [PECAM-1] expression *induced* by . Positive_regulation PECAM1 TNF 17607964 1765403 The cultures pretreated with Epo reduced ICAM-1 and [PECAM-I] expression *induced* by from 70.0 +/- 3.94 % to 59.3 +/- 0.60 % and from 83.4 +/- 2.27 % to 57.7 +/- 0.66 % respectively for ICAM-1 and PECAM-1 . Positive_regulation PECAM1 TNF 19828693 2168891 In vitro , TEM was mediated by EFNA4 binding to endothelial EphA2 receptor , which is highly expressed in *activated* HUVECs as well as in the [CD31] ( + ) endothelial cells of human lymph nodes . Positive_regulation PECAM1 VCAM1 9506571 491442 In early lesions , expression of [PECAM-1] , ICAM-1 , ICAM-2 , and P-selectin was similar to that in control samples , and and E-selectin were *induced* in vascular endothelium . Positive_regulation PECAM1 VEGFA 16151023 1467399 Second , we used D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol ( D-PDMP ) , an inhibitor of LacCer synthase and glucosylceramide synthase , that significantly mitigated *induced* [PECAM-1] expression and angiogenesis . Positive_regulation PECAM1 VEGFA 16151023 1467400 Also , *induced* [PECAM-1] expression and angiogenesis was mitigated by protein kinase C and phospholipase A2 inhibitors . Positive_regulation PECAM1 VEGFA 16990600 1673996 indeed *induced* a differential expression of VCAM-1 and [PECAM-1] in endothelial cells . Positive_regulation PECAM1 VEGFA 19080715 2003356 In the *presence* of and FGF , the sprouts branching from the EBs assimilated Dil-AcLDL , expressed [CD31] and formed a 3-dimensional cylindrical organization . Positive_regulation PECAM1 VEGFA 19219548 2086527 Mechanistic studies revealed that the use of LY294002 , a PI3 kinase inhibitor , mitigated *induced* expression of platelet-endothelial cell adhesion molecule ( [PECAM-1/CD31] ) ; Positive_regulation PECAM1 VEGFA 24625025 2925474 Bevacizumab treatment *induced* significant low expression of mouse [Pecam1/Cd31] , Eng/Cd105 , Flt1/Vegfr1 and Kdr/Vefr2 while the human PECAM1/CD31 and were upregulated . Positive_regulation PECAM1 WDR61 12709415 1093368 The activated *increased* the mucosal IL-6 and [PECAM-1] , enhanced the expression of FasL but not Fas , and led to the cleavage of Bid and the release of cytochrome c from mitochondria to activate caspase-9 . Positive_regulation PELI1 TLR7 22007846 2526491 The IKK related kinases are also the major protein kinases that activate [Pellino 1] in *response* to ( Toll-like receptor ) ligands that signal via the adaptors MyD88 ( myeloid differentiation primary response gene 88 ) and/or TRIF [ TIR ( Toll/IL-1 receptor ) domain containing adaptor protein inducing interferon ß ] . Positive_regulation PENK IL1B 1478730 207512 *regulates* [proenkephalin] gene expression in astrocytes cultured from rat cortex . Positive_regulation PENK IL1B 1478730 207514 [Proenkephalin] mRNA expression was *stimulated* by in a time- and concentration dependent manner , being maximal with 5 U/ml IL-1 beta at 4 h . Positive_regulation PENK IL1B 1478730 207515 also *regulated* a [proenkephalin-chloramphenicol] acetyltransferase fusion gene transiently transfected into astrocytes , with a dose-response similar to that active in proenkephalin mRNA . Positive_regulation PENK IL1B 8522984 345868 The enhanced mu-receptor mRNA expression , together with the previous observation that *stimulates* [proenkephalin] synthesis in astrocytes , supports the IL1 beta mediated regulation of an astroglial opioid peptide and receptor in vitro , a phenomenon that may be significant in the modulation of the gliotic response to neuronal damage . Positive_regulation PEPD EPHB2 17169973 1701490 Supporting evidence comes from experiments showing that specific inhibitor ( UO126 ) *inhibited* CPT induced up-regulation of [prolidase] activity while it had no effect on CPT induced inhibition of collagen biosynthesis and activation of NF-kappaB . Positive_regulation PEPD MAP2K6 17169973 1701496 Supporting evidence comes from experiments showing that specific inhibitor ( UO126 ) *inhibited* CPT induced up-regulation of [prolidase] activity while it had no effect on CPT induced inhibition of collagen biosynthesis and activation of NF-kappaB . Positive_regulation PER1 ADRB2 17299247 1698963 In our studies of clock gene mRNA expressions in human bronchial epithelial cells in vitro and peripheral blood cells in vivo , we demonstrated that glucocorticoid or agonist treatment strongly *induced* human [Per1] mRNA expression both in vitro and in vivo . Positive_regulation PER1 TFPI2 16790549 1585807 Expression of a dominant negative PP5 mutant reduces [PER] phosphorylation by CKIepsilon in vivo , and down-regulation of significantly *reduces* the amplitude of circadian cycling in cultured human fibroblasts . Positive_regulation PET100 AGR2 14737544 1199706 The reactions of 2,4,6-trifluorophenylboronic acid with aryl ( iodo ) palladium ( ii ) complexes , trans-Pd ( C ( 6 ) F ( 5 ) ) I ( PR(3) ) ( 2 ) ( PR(3)= [PEt] ( 3 ) , PMe ( 2 ) Ph , PMePh ( 2 ) ) in the *presence* of afforded trans-Pd ( C ( 6 ) F(5))(2,4,6-C ( 6 ) F ( 3 ) H ( 2 ) ) ( PR(3) ) ( 2 ) which are stabilized by fluorine atoms in the ortho positions . Positive_regulation PET112 AGR2 14737544 1199708 The reactions of 2,4,6-trifluorophenylboronic acid with aryl ( iodo ) palladium ( ii ) complexes , trans-Pd ( C ( 6 ) F ( 5 ) ) I ( PR(3) ) ( 2 ) ( PR(3)= [PEt] ( 3 ) , PMe ( 2 ) Ph , PMePh ( 2 ) ) in the *presence* of afforded trans-Pd ( C ( 6 ) F(5))(2,4,6-C ( 6 ) F ( 3 ) H ( 2 ) ) ( PR(3) ) ( 2 ) which are stabilized by fluorine atoms in the ortho positions . Positive_regulation PET117 AGR2 14737544 1199707 The reactions of 2,4,6-trifluorophenylboronic acid with aryl ( iodo ) palladium ( ii ) complexes , trans-Pd ( C ( 6 ) F ( 5 ) ) I ( PR(3) ) ( 2 ) ( PR(3)= [PEt] ( 3 ) , PMe ( 2 ) Ph , PMePh ( 2 ) ) in the *presence* of afforded trans-Pd ( C ( 6 ) F(5))(2,4,6-C ( 6 ) F ( 3 ) H ( 2 ) ) ( PR(3) ) ( 2 ) which are stabilized by fluorine atoms in the ortho positions . Positive_regulation PF4 TNF 10590045 572276 In previous studies , we found that [PF-4] specifically binds to human polymorphonuclear granulocytes ( PMN ) , but *requires* as a costimulus for the induction of effector functions in suspended cells . Positive_regulation PFN1 EPHB2 22693641 2615629 Our findings reveal that ACE2 deficiency worsens Ang II-mediated aortic inflammation and peroxynitrite production associated with the augmentation of [profilin-1] expression and the *activation* of the signaling , suggesting potential therapeutic approaches by enhancing ACE2 action for patients with vascular diseases . Positive_regulation PGA3 TNF 19514423 2092707 Patients with highly active hepatitis and maximal morphological changes in the liver had significant lowering of NDV induced production of IFN-alpha , IFN-gamma , TNF-alpha , IL-6 and [PGA] *induced* production of . Positive_regulation PGA4 TNF 19514423 2092708 Patients with highly active hepatitis and maximal morphological changes in the liver had significant lowering of NDV induced production of IFN-alpha , IFN-gamma , TNF-alpha , IL-6 and [PGA] *induced* production of . Positive_regulation PGA5 TNF 19514423 2092709 Patients with highly active hepatitis and maximal morphological changes in the liver had significant lowering of NDV induced production of IFN-alpha , IFN-gamma , TNF-alpha , IL-6 and [PGA] *induced* production of . Positive_regulation PGC ABRA 23720020 2827959 overexpression *increased* [Pgc-1a] , Srf , Ckmt2 , Cpt-1ß , and Mhc1 mRNA . Positive_regulation PGC ACACA 21803289 2462282 Deletion of mIndy in mice ( mINDY ( -/- ) mice ) reduces hepatocellular ATP/ADP ratio , activates hepatic AMPK , *induces* [PGC-1a] , inhibits , and reduces SREBP-1c levels . Positive_regulation PGC ACADM 12522104 1063976 In support of this hypothesis , adenovirus mediated delivery of small interfering RNA for ERRalpha , or of PGC-1 mutants that interact selectively with different types of nuclear receptors , shows that [PGC-1] can *induce* the fatty acid oxidation enzyme ( medium-chain acyl-coenzyme A dehydrogenase ) in an ERRalpha dependent manner . Positive_regulation PGC ADIPOQ 22415879 2600584 Therefore , our study indicates that *enhances* p38 [MAPK/PGC-1a] signaling and mitochondrial biogenesis in skeletal muscle by suppressing MKP1 expression . Positive_regulation PGC ADRB3 11369446 817414 These results show that selective stimulation of the rapidly *upregulates* the expression of [PGC-1] in brown adipocytes without a concomitant increase in PPARgamma2 . Positive_regulation PGC AKT1 22249024 2575344 Integrin dependent activation *regulates* [PGC-1] expression and fatty acid oxidation . Positive_regulation PGC AKT1 22249024 2575347 Our findings imply a linear pathway whereby an integrin dependent activation of *leads* to increased [PGC-1a] and PDK4 expression resulting in increased energy production by fatty acid oxidation . Positive_regulation PGC ANGPT2 10354287 617770 Combined ET and type 1 blockade completely *prevented* the increase in systemic BP , [PGC] , and RE and the fall in Kf with systemic NOS inhibition , leaving only a very attenuated rise in RA . Positive_regulation PGC APP 24304563 2921423 Importantly , *increases* [PGC-1a] expression also in the mice brain . Positive_regulation PGC BMP2 11401407 824435 These results suggest that [PGC] generation in the mouse embryo is *regulated* not only by extraembryonic ectoderm derived BMP4 and BMP8B , but also by endoderm derived . Positive_regulation PGC BMP4 11401407 824433 Previous studies have demonstrated that extraembryonic ectoderm derived and BMP8B are both *required* for [PGC] generation . Positive_regulation PGC BMP4 11401407 824436 These results suggest that [PGC] generation in the mouse embryo is *regulated* not only by extraembryonic ectoderm derived and BMP8B , but also by endoderm derived BMP2 . Positive_regulation PGC BMP4 11707591 879634 Our results clearly demonstrate that made in the ExM does not affect the establishment of either PGC or allantois lineages , but is *required* for [PGC] localization and survival and for the differentiation of the allantois . Positive_regulation PGC BMP4 12806005 1030709 Both and 8b ( Bmp8b ) are expressed in the extraembryonic ectoderm and are *required* for [PGC] formation . Positive_regulation PGC BMP8B 10894154 711493 In this study , we report that , a member of the Gbb-60A class of the BMP superfamily , is expressed in the extraembryonic ectoderm in pregastrula and gastrula stage mouse embryos and is *required* for [PGC] generation . Positive_regulation PGC BMP8B 11401407 824434 Previous studies have demonstrated that extraembryonic ectoderm derived BMP4 and are both *required* for [PGC] generation . Positive_regulation PGC CA2 12665481 1074762 In this study , we tested the hypothesis that raising cytosolic in L6 myotubes *induces* increased expression of [PGC-1] , NRF-1 , NRF-2 , and mtTFA , factors that have been implicated in mitochondrial biogenesis and in the adaptation of muscle to exercise . Positive_regulation PGC CA2 12665481 1074767 Raising cytosolic by exposing L6 myotubes to caffeine for 5 h *induced* significant increases in [PGC-1] and mtTFA protein expression and in NRF-1 and NRF-2 binding to DNA . Positive_regulation PGC CALM3 20799369 2318201 Using the same animal model , the present study investigated the role of *dependent* protein kinase IV ( CaMKIV ) and [PGC-1a] in delayed neuronal cell death and mitochondrial biogenesis in the hippocampus . Positive_regulation PGC CAMK1 11951046 930434 induced expression of peroxisome proliferator activated receptor gamma coactivator 1 ( PGC-1 ) , a master regulator of mitochondrial biogenesis in vivo , and *activated* the [PGC-1] gene promoter in cultured myocytes . Positive_regulation PGC CAMK4 11951046 930435 induced expression of peroxisome proliferator activated receptor gamma coactivator 1 ( PGC-1 ) , a master regulator of mitochondrial biogenesis in vivo , and *activated* the [PGC-1] gene promoter in cultured myocytes . Positive_regulation PGC CPT1A 22990076 2698001 PPARd , [PGC-1a] , FAT/CD36 , and LPL content were *enhanced* following acute exercise , whereas PPARa , AMPKa , , and COX-IV content were enhanced only after exercise training . Positive_regulation PGC CREB1 11557984 861456 Fasting hyperglycaemia is strongly correlated with type II diabetes , so our results suggest that the *activation* of [PGC-1] by in liver contributes importantly to the pathogenesis of this disease . Positive_regulation PGC CREB1 14614508 1163637 The coordinate *induction* of [PGC-1] and repression of PPAR-gamma by during fasting provides a molecular rationale for the antagonism between insulin and counter-regulatory hormones , and indicates a potential role for CREB antagonists as therapeutic agents in enhancing insulin sensitivity in the liver . Positive_regulation PGC CREB1 21156859 2390405 Our results also provided new mechanisms in myotubes that the p38 MAPK induced [PGC-1a] gene transcription was *mediated* by . Positive_regulation PGC CREB1 22767158 2676371 hesperetin activates PI-3 K , PKA , PKC , ERK1 and , and it *induces* PI-3 K , PKA , [PGC-1a] and seladin-1 via both ER and TrkA ; Positive_regulation PGC CREB1 23220172 2736570 Similarly , inhibition *reduced* CREB activation and [PGC-1a] protein levels in selenoprotein H transfected cells . Positive_regulation PGC CREB1 24829353 2950846 By using promoter-luciferase reporters , kinase inhibitors , and dominant negative mutants , we further observed that the HCV induced upregulation of [WT-PGC-1a] was *mediated* by the phosphorylation of cyclic AMP ( cAMP ) -responsive element binding protein ( CREB ) , whereas that of L-PGC-1a was mediated by phosphorylation and forkhead box O1 dephosphorylation . Positive_regulation PGC CREB1 24829353 2950849 WT-PGC-1a upregulation was mediated by CREB phosphorylation , whereas [L-PGC-1a] upregulation was *mediated* by phosphorylation and FoxO1 dephosphorylation . Positive_regulation PGC CREB1 24931672 2946941 Our results indicate that 14,15-EET protects neurons from OGD induced apoptosis by promoting mitochondrial biogenesis and function through *mediated* activation of [PGC-1a] and NRF-1 . Positive_regulation PGC CREB3 11557984 861457 Fasting hyperglycaemia is strongly correlated with type II diabetes , so our results suggest that the *activation* of [PGC-1] by in liver contributes importantly to the pathogenesis of this disease . Positive_regulation PGC CREB3 14614508 1163638 The coordinate *induction* of [PGC-1] and repression of PPAR-gamma by during fasting provides a molecular rationale for the antagonism between insulin and counter-regulatory hormones , and indicates a potential role for CREB antagonists as therapeutic agents in enhancing insulin sensitivity in the liver . Positive_regulation PGC CREB3 21156859 2390406 Our results also provided new mechanisms in myotubes that the p38 MAPK induced [PGC-1a] gene transcription was *mediated* by . Positive_regulation PGC CREB3 22767158 2676372 hesperetin activates PI-3 K , PKA , PKC , ERK1 and , and it *induces* PI-3 K , PKA , [PGC-1a] and seladin-1 via both ER and TrkA ; Positive_regulation PGC CREB3 23220172 2736571 Similarly , inhibition *reduced* CREB activation and [PGC-1a] protein levels in selenoprotein H transfected cells . Positive_regulation PGC CREB3 24829353 2950847 By using promoter-luciferase reporters , kinase inhibitors , and dominant negative mutants , we further observed that the HCV induced upregulation of [WT-PGC-1a] was *mediated* by the phosphorylation of cyclic AMP ( cAMP ) -responsive element binding protein ( CREB ) , whereas that of L-PGC-1a was mediated by phosphorylation and forkhead box O1 dephosphorylation . Positive_regulation PGC CREB3 24829353 2950850 [WT-PGC-1a] upregulation was *mediated* by phosphorylation , whereas L-PGC-1a upregulation was mediated by CREB phosphorylation and FoxO1 dephosphorylation . Positive_regulation PGC CREB3 24931672 2946942 Our results indicate that 14,15-EET protects neurons from OGD induced apoptosis by promoting mitochondrial biogenesis and function through *mediated* activation of [PGC-1a] and NRF-1 . Positive_regulation PGC CREB5 11557984 861455 Fasting hyperglycaemia is strongly correlated with type II diabetes , so our results suggest that the *activation* of [PGC-1] by in liver contributes importantly to the pathogenesis of this disease . Positive_regulation PGC CREB5 14614508 1163636 The coordinate *induction* of [PGC-1] and repression of PPAR-gamma by during fasting provides a molecular rationale for the antagonism between insulin and counter-regulatory hormones , and indicates a potential role for CREB antagonists as therapeutic agents in enhancing insulin sensitivity in the liver . Positive_regulation PGC CREB5 21156859 2390404 Our results also provided new mechanisms in myotubes that the p38 MAPK induced [PGC-1a] gene transcription was *mediated* by . Positive_regulation PGC CREB5 22767158 2676370 hesperetin activates PI-3 K , PKA , PKC , ERK1 and , and it *induces* PI-3 K , PKA , [PGC-1a] and seladin-1 via both ER and TrkA ; Positive_regulation PGC CREB5 23220172 2736569 Similarly , inhibition *reduced* CREB activation and [PGC-1a] protein levels in selenoprotein H transfected cells . Positive_regulation PGC CREB5 24829353 2950845 By using promoter-luciferase reporters , kinase inhibitors , and dominant negative mutants , we further observed that the HCV induced upregulation of [WT-PGC-1a] was *mediated* by the phosphorylation of cyclic AMP ( cAMP ) -responsive element binding protein ( CREB ) , whereas that of L-PGC-1a was mediated by phosphorylation and forkhead box O1 dephosphorylation . Positive_regulation PGC CREB5 24829353 2950848 [WT-PGC-1a] upregulation was *mediated* by phosphorylation , whereas L-PGC-1a upregulation was mediated by CREB phosphorylation and FoxO1 dephosphorylation . Positive_regulation PGC CREB5 24931672 2946940 Our results indicate that 14,15-EET protects neurons from OGD induced apoptosis by promoting mitochondrial biogenesis and function through *mediated* activation of [PGC-1a] and NRF-1 . Positive_regulation PGC EPO 23523698 2794279 These data suggest that contributes to skeletal muscle fiber programming and metabolism , and *increases* [PGC-1a] and AMPK activity during muscle development directly to affect the proportion of slow/fast twitch myofibers in mature skeletal muscle . Positive_regulation PGC ESRRA 12522104 1063974 First , [PGC-1] *induces* the expression of . Positive_regulation PGC FGF21 22302939 2551946 *regulates* [PGC-1a] and browning of white adipose tissues in adaptive thermogenesis . Positive_regulation PGC FIS1 22769563 2659822 IL-6 over-expression in pre-cachectic mice accelerated body weight loss and muscle wasting , without reducing mitochondrial content , while [PGC-1a] and Mfn1/Mfn2 protein expression was suppressed and protein expression *induced* . Positive_regulation PGC FOXO1 12606503 1062901 Coexpression of *stimulates* the [PGC-1] promoter activity via interaction with the IRSs , while coexpression of FKHR ( 3A ) , in which the three putative PKB sites in FKHR are mutated , mainly abolishes the suppressive effect of PKB . Positive_regulation PGC FOXO1 22009745 2516463 Here we describe a novel human liver-specific [PGC-1a] transcript that results from alternative promoter usage and is *induced* by as well as glucocorticoids and cAMP-response element binding protein signaling but is not present in other mammals . Positive_regulation PGC FOXO3 22076434 2599448 Interestingly , administering fenofibrate or tempol to the HFD induced SHRs reversed all of the renal phenotypes by increasing the PPARa expression with concomitant inactivation of the PI3K-Akt pathway , dephosphorylation of and *activation* of [PGC-1a-ERR-1a] signaling , and this all resulted in ameliorating the oxidative stress and apoptotic cell death . Positive_regulation PGC GCG 12107181 991471 Finally , we show that the transcriptional *induction* of the [PGC-1] gene by through cAMP in hepatocytes precedes that of L-CPT-1 . Positive_regulation PGC GCG 22117073 2534997 Overexpression of PGC-1a and *induction* of [PGC-1a] by fasting , physical exercise , , or cAMP was associated with increased IL1Rn mRNA and protein expression in hepatocytes . Positive_regulation PGC GRAP2 23443926 2771446 ß-Adrenergic stimulation does not activate MAP kinase or *induce* [PGC-1a] in skeletal muscle . Positive_regulation PGC HTT 21715619 2447228 Importantly , expression of mutant in primary oligodendrocytes *resulted* in decreased expression of [PGC1a] and its targets HmgcS1 , Hmgcr , and MBP . Positive_regulation PGC IGF1 23217713 2707905 Rather , it specifically induces and represses myostatin , and expression of [PGC-1a4] in vitro and in vivo *induces* robust skeletal muscle hypertrophy . Positive_regulation PGC IL4 16814729 1580850 We show here that in *response* to , signal transducer and activator of transcription 6 ( STAT6 ) and [PPARgamma-coactivator-1beta (PGC-1beta)] induce macrophage programs for fatty acid oxidation and mitochondrial biogenesis . Positive_regulation PGC IL6 23240005 2708490 Our findings demonstrate depot-specific differences in the ability of to *induce* [PGC-1a] and mitochondrial enzymes and demonstrate that IL-6 is not necessary for the maintenance of adipose tissue mitochondrial content in vivo . Positive_regulation PGC IRF4 24995979 2948305 also *induces* the expression of [PGC-1a] and PRDM16 and interacts with PGC-1a , driving Ucp1 expression . Positive_regulation PGC KAT2A 21888529 2491581 Further research examining exercise mediated activation of SIRT1 and the *role* of in regulating [PGC-1a] transcriptional activity in skeletal muscle is required . Positive_regulation PGC KSR1 21518958 2434990 *regulates* [PGC1a] and estrogen related receptor a to promote oncogenic Ras dependent anchorage independent growth . Positive_regulation PGC LEP 11108270 756817 We conclude that action is *required* for normal basal and cold stimulated [PGC-1] expression in BAT in rodents and that hyperleptinemia rapidly up-regulates its expression , at least in part , by direct action . Positive_regulation PGC LIPE 21505145 2444329 Inhibiting in 3T3-L1 adipocytes also *potentiated* the induction of [PGC-1a] , UCP1 , and NOR-1 by ß-AR activation , as did siRNA knockdown of adipose triglyceride lipase , the rate limiting enzyme for lipolysis . Positive_regulation PGC MAD2L2 24009519 2836859 We demonstrated that is *essential* for [PGC] , but not somatic development . Positive_regulation PGC MAPK1 11481440 843667 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Positive_regulation PGC MAPK1 21156859 2390376 Our results showed that the basal level of p38 MAPK phosphorylation was increased in gastrocnemius of mice under HFD and that p38 *stimulated* [PGC-1a] gene transcription in C ( 2 ) C ( 12 ) myotubes . Positive_regulation PGC MAPK1 21156859 2390408 Our results also provided new mechanisms in myotubes that the p38 *induced* [PGC-1a] gene transcription was mediated by CREB . Positive_regulation PGC MAPK1 21156859 2390446 The p38 *induced* [PGC-1a] gene transcription was prevented by insulin . Positive_regulation PGC MAPK1 23443926 2771448 In brown adipocytes , the increase in [PGC-1a] expression induced by ß-adrenergic stimulation is *mediated* by activation of p38 mitogen activated protein kinase ( p38 ) , which phosphorylates and activates the cAMP response element binding protein ( CREB ) family member activating transcription factor 2 ( ATF2 ) , which binds to a cyclic AMP response element ( CRE ) in the PGC-1a promoter and mediates the increase in PGC-1a transcription . Positive_regulation PGC MAPK10 11481440 843668 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Positive_regulation PGC MAPK10 21156859 2390377 Our results showed that the basal level of p38 MAPK phosphorylation was increased in gastrocnemius of mice under HFD and that p38 *stimulated* [PGC-1a] gene transcription in C ( 2 ) C ( 12 ) myotubes . Positive_regulation PGC MAPK10 21156859 2390409 Our results also provided new mechanisms in myotubes that the p38 *induced* [PGC-1a] gene transcription was mediated by CREB . Positive_regulation PGC MAPK10 21156859 2390447 The p38 *induced* [PGC-1a] gene transcription was prevented by insulin . Positive_regulation PGC MAPK10 23443926 2771449 In brown adipocytes , the increase in [PGC-1a] expression induced by ß-adrenergic stimulation is *mediated* by activation of p38 ( p38 MAPK ) , which phosphorylates and activates the cAMP response element binding protein ( CREB ) family member activating transcription factor 2 ( ATF2 ) , which binds to a cyclic AMP response element ( CRE ) in the PGC-1a promoter and mediates the increase in PGC-1a transcription . Positive_regulation PGC MAPK11 11481440 843669 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Positive_regulation PGC MAPK11 21156859 2390378 Our results showed that the basal level of p38 MAPK phosphorylation was increased in gastrocnemius of mice under HFD and that p38 *stimulated* [PGC-1a] gene transcription in C ( 2 ) C ( 12 ) myotubes . Positive_regulation PGC MAPK11 21156859 2390410 Our results also provided new mechanisms in myotubes that the p38 *induced* [PGC-1a] gene transcription was mediated by CREB . Positive_regulation PGC MAPK11 21156859 2390448 The p38 *induced* [PGC-1a] gene transcription was prevented by insulin . Positive_regulation PGC MAPK11 23443926 2771450 In brown adipocytes , the increase in [PGC-1a] expression induced by ß-adrenergic stimulation is *mediated* by activation of p38 mitogen activated protein kinase ( p38 ) , which phosphorylates and activates the cAMP response element binding protein ( CREB ) family member activating transcription factor 2 ( ATF2 ) , which binds to a cyclic AMP response element ( CRE ) in the PGC-1a promoter and mediates the increase in PGC-1a transcription . Positive_regulation PGC MAPK12 11481440 843670 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Positive_regulation PGC MAPK12 21156859 2390379 Our results showed that the basal level of p38 MAPK phosphorylation was increased in gastrocnemius of mice under HFD and that p38 *stimulated* [PGC-1a] gene transcription in C ( 2 ) C ( 12 ) myotubes . Positive_regulation PGC MAPK12 21156859 2390411 Our results also provided new mechanisms in myotubes that the p38 *induced* [PGC-1a] gene transcription was mediated by CREB . Positive_regulation PGC MAPK12 21156859 2390449 The p38 *induced* [PGC-1a] gene transcription was prevented by insulin . Positive_regulation PGC MAPK12 23443926 2771451 In brown adipocytes , the increase in [PGC-1a] expression induced by ß-adrenergic stimulation is *mediated* by activation of p38 ( p38 MAPK ) , which phosphorylates and activates the cAMP response element binding protein ( CREB ) family member activating transcription factor 2 ( ATF2 ) , which binds to a cyclic AMP response element ( CRE ) in the PGC-1a promoter and mediates the increase in PGC-1a transcription . Positive_regulation PGC MAPK13 11481440 843671 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Positive_regulation PGC MAPK13 21156859 2390380 Our results showed that the basal level of p38 MAPK phosphorylation was increased in gastrocnemius of mice under HFD and that p38 *stimulated* [PGC-1a] gene transcription in C ( 2 ) C ( 12 ) myotubes . Positive_regulation PGC MAPK13 21156859 2390412 Our results also provided new mechanisms in myotubes that the p38 *induced* [PGC-1a] gene transcription was mediated by CREB . Positive_regulation PGC MAPK13 21156859 2390450 The p38 *induced* [PGC-1a] gene transcription was prevented by insulin . Positive_regulation PGC MAPK13 23443926 2771452 In brown adipocytes , the increase in [PGC-1a] expression induced by ß-adrenergic stimulation is *mediated* by activation of p38 mitogen activated protein kinase ( p38 ) , which phosphorylates and activates the cAMP response element binding protein ( CREB ) family member activating transcription factor 2 ( ATF2 ) , which binds to a cyclic AMP response element ( CRE ) in the PGC-1a promoter and mediates the increase in PGC-1a transcription . Positive_regulation PGC MAPK14 11481440 843672 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Positive_regulation PGC MAPK14 21156859 2390381 Our results showed that the basal level of p38 MAPK phosphorylation was increased in gastrocnemius of mice under HFD and that p38 *stimulated* [PGC-1a] gene transcription in C ( 2 ) C ( 12 ) myotubes . Positive_regulation PGC MAPK14 21156859 2390413 Our results also provided new mechanisms in myotubes that the p38 *induced* [PGC-1a] gene transcription was mediated by CREB . Positive_regulation PGC MAPK14 21156859 2390451 The p38 *induced* [PGC-1a] gene transcription was prevented by insulin . Positive_regulation PGC MAPK14 23443926 2771453 In brown adipocytes , the increase in [PGC-1a] expression induced by ß-adrenergic stimulation is *mediated* by activation of p38 mitogen activated protein kinase ( p38 ) , which phosphorylates and activates the cAMP response element binding protein ( CREB ) family member activating transcription factor 2 ( ATF2 ) , which binds to a cyclic AMP response element ( CRE ) in the PGC-1a promoter and mediates the increase in PGC-1a transcription . Positive_regulation PGC MAPK15 11481440 843666 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Positive_regulation PGC MAPK15 21156859 2390375 Our results showed that the basal level of p38 MAPK phosphorylation was increased in gastrocnemius of mice under HFD and that p38 *stimulated* [PGC-1a] gene transcription in C ( 2 ) C ( 12 ) myotubes . Positive_regulation PGC MAPK15 21156859 2390407 Our results also provided new mechanisms in myotubes that the p38 *induced* [PGC-1a] gene transcription was mediated by CREB . Positive_regulation PGC MAPK15 21156859 2390445 The p38 *induced* [PGC-1a] gene transcription was prevented by insulin . Positive_regulation PGC MAPK15 23443926 2771447 In brown adipocytes , the increase in [PGC-1a] expression induced by ß-adrenergic stimulation is *mediated* by activation of p38 ( p38 MAPK ) , which phosphorylates and activates the cAMP response element binding protein ( CREB ) family member activating transcription factor 2 ( ATF2 ) , which binds to a cyclic AMP response element ( CRE ) in the PGC-1a promoter and mediates the increase in PGC-1a transcription . Positive_regulation PGC MAPK3 11481440 843673 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Positive_regulation PGC MAPK3 21156859 2390382 Our results showed that the basal level of p38 MAPK phosphorylation was increased in gastrocnemius of mice under HFD and that p38 *stimulated* [PGC-1a] gene transcription in C ( 2 ) C ( 12 ) myotubes . Positive_regulation PGC MAPK3 21156859 2390414 Our results also provided new mechanisms in myotubes that the p38 *induced* [PGC-1a] gene transcription was mediated by CREB . Positive_regulation PGC MAPK3 21156859 2390452 The p38 *induced* [PGC-1a] gene transcription was prevented by insulin . Positive_regulation PGC MAPK3 22767158 2676373 hesperetin activates PI-3 K , PKA , PKC , and CREB , and it *induces* PI-3 K , PKA , [PGC-1a] and seladin-1 via both ER and TrkA ; Positive_regulation PGC MAPK3 23443926 2771454 In brown adipocytes , the increase in [PGC-1a] expression induced by ß-adrenergic stimulation is *mediated* by activation of p38 ( p38 MAPK ) , which phosphorylates and activates the cAMP response element binding protein ( CREB ) family member activating transcription factor 2 ( ATF2 ) , which binds to a cyclic AMP response element ( CRE ) in the PGC-1a promoter and mediates the increase in PGC-1a transcription . Positive_regulation PGC MAPK4 11481440 843674 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Positive_regulation PGC MAPK4 21156859 2390383 Our results showed that the basal level of p38 MAPK phosphorylation was increased in gastrocnemius of mice under HFD and that p38 *stimulated* [PGC-1a] gene transcription in C ( 2 ) C ( 12 ) myotubes . Positive_regulation PGC MAPK4 21156859 2390415 Our results also provided new mechanisms in myotubes that the p38 *induced* [PGC-1a] gene transcription was mediated by CREB . Positive_regulation PGC MAPK4 21156859 2390453 The p38 *induced* [PGC-1a] gene transcription was prevented by insulin . Positive_regulation PGC MAPK4 23443926 2771455 In brown adipocytes , the increase in [PGC-1a] expression induced by ß-adrenergic stimulation is *mediated* by activation of p38 mitogen activated protein kinase ( p38 ) , which phosphorylates and activates the cAMP response element binding protein ( CREB ) family member activating transcription factor 2 ( ATF2 ) , which binds to a cyclic AMP response element ( CRE ) in the PGC-1a promoter and mediates the increase in PGC-1a transcription . Positive_regulation PGC MAPK6 11481440 843675 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Positive_regulation PGC MAPK6 21156859 2390384 Our results showed that the basal level of p38 MAPK phosphorylation was increased in gastrocnemius of mice under HFD and that p38 *stimulated* [PGC-1a] gene transcription in C ( 2 ) C ( 12 ) myotubes . Positive_regulation PGC MAPK6 21156859 2390416 Our results also provided new mechanisms in myotubes that the p38 *induced* [PGC-1a] gene transcription was mediated by CREB . Positive_regulation PGC MAPK6 21156859 2390454 The p38 *induced* [PGC-1a] gene transcription was prevented by insulin . Positive_regulation PGC MAPK6 23443926 2771456 In brown adipocytes , the increase in [PGC-1a] expression induced by ß-adrenergic stimulation is *mediated* by activation of p38 ( p38 MAPK ) , which phosphorylates and activates the cAMP response element binding protein ( CREB ) family member activating transcription factor 2 ( ATF2 ) , which binds to a cyclic AMP response element ( CRE ) in the PGC-1a promoter and mediates the increase in PGC-1a transcription . Positive_regulation PGC MAPK7 11481440 843676 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Positive_regulation PGC MAPK7 21156859 2390385 Our results showed that the basal level of p38 MAPK phosphorylation was increased in gastrocnemius of mice under HFD and that p38 *stimulated* [PGC-1a] gene transcription in C ( 2 ) C ( 12 ) myotubes . Positive_regulation PGC MAPK7 21156859 2390417 Our results also provided new mechanisms in myotubes that the p38 *induced* [PGC-1a] gene transcription was mediated by CREB . Positive_regulation PGC MAPK7 21156859 2390455 The p38 *induced* [PGC-1a] gene transcription was prevented by insulin . Positive_regulation PGC MAPK7 23443926 2771457 In brown adipocytes , the increase in [PGC-1a] expression induced by ß-adrenergic stimulation is *mediated* by activation of p38 mitogen activated protein kinase ( p38 ) , which phosphorylates and activates the cAMP response element binding protein ( CREB ) family member activating transcription factor 2 ( ATF2 ) , which binds to a cyclic AMP response element ( CRE ) in the PGC-1a promoter and mediates the increase in PGC-1a transcription . Positive_regulation PGC MAPK8 11481440 843677 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Positive_regulation PGC MAPK8 21156859 2390386 Our results showed that the basal level of p38 MAPK phosphorylation was increased in gastrocnemius of mice under HFD and that p38 *stimulated* [PGC-1a] gene transcription in C ( 2 ) C ( 12 ) myotubes . Positive_regulation PGC MAPK8 21156859 2390418 Our results also provided new mechanisms in myotubes that the p38 *induced* [PGC-1a] gene transcription was mediated by CREB . Positive_regulation PGC MAPK8 21156859 2390456 The p38 *induced* [PGC-1a] gene transcription was prevented by insulin . Positive_regulation PGC MAPK8 23443926 2771458 In brown adipocytes , the increase in [PGC-1a] expression induced by ß-adrenergic stimulation is *mediated* by activation of p38 mitogen activated protein kinase ( p38 ) , which phosphorylates and activates the cAMP response element binding protein ( CREB ) family member activating transcription factor 2 ( ATF2 ) , which binds to a cyclic AMP response element ( CRE ) in the PGC-1a promoter and mediates the increase in PGC-1a transcription . Positive_regulation PGC MAPK9 11481440 843678 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Positive_regulation PGC MAPK9 21156859 2390387 Our results showed that the basal level of p38 MAPK phosphorylation was increased in gastrocnemius of mice under HFD and that p38 *stimulated* [PGC-1a] gene transcription in C ( 2 ) C ( 12 ) myotubes . Positive_regulation PGC MAPK9 21156859 2390419 Our results also provided new mechanisms in myotubes that the p38 *induced* [PGC-1a] gene transcription was mediated by CREB . Positive_regulation PGC MAPK9 21156859 2390457 The p38 *induced* [PGC-1a] gene transcription was prevented by insulin . Positive_regulation PGC MAPK9 23443926 2771459 In brown adipocytes , the increase in [PGC-1a] expression induced by ß-adrenergic stimulation is *mediated* by activation of p38 ( p38 MAPK ) , which phosphorylates and activates the cAMP response element binding protein ( CREB ) family member activating transcription factor 2 ( ATF2 ) , which binds to a cyclic AMP response element ( CRE ) in the PGC-1a promoter and mediates the increase in PGC-1a transcription . Positive_regulation PGC MSH2 23201126 2724062 signaling strongly induces PGC-1a expression and *stabilizes* both PGC-1a and [PGC-1ß] proteins . Positive_regulation PGC MSH3 23201126 2724063 signaling strongly induces PGC-1a expression and *stabilizes* both PGC-1a and [PGC-1ß] proteins . Positive_regulation PGC MSH4 23201126 2724064 signaling strongly induces PGC-1a expression and *stabilizes* both PGC-1a and [PGC-1ß] proteins . Positive_regulation PGC MSH5 23201126 2724065 signaling strongly induces PGC-1a expression and *stabilizes* both PGC-1a and [PGC-1ß] proteins . Positive_regulation PGC MSH6 23201126 2724066 signaling strongly induces PGC-1a expression and *stabilizes* both PGC-1a and [PGC-1ß] proteins . Positive_regulation PGC MSTN 23217713 2707904 Rather , it specifically induces IGF1 and represses , and expression of [PGC-1a4] in vitro and in vivo *induces* robust skeletal muscle hypertrophy . Positive_regulation PGC MYLIP 23834033 2865815 Hepatic overexpression of *reduced* NAMPT/NAD ( + ) levels , increased acetylation of the SIRT1 target transcriptional regulators , [PGC-1a] , SREBP-1c , FXR , and NF-?B , and resulted in obesity-mimetic outcomes . Positive_regulation PGC NOTCH1 24506866 2914232 Mechanistically , [PGC-1a] *induces* signaling , blunts activation of Rac/Akt/eNOS signaling , and renders endothelial cells unresponsive to established angiogenic factors . Positive_regulation PGC NOTCH2 24506866 2914233 Mechanistically , [PGC-1a] *induces* signaling , blunts activation of Rac/Akt/eNOS signaling , and renders endothelial cells unresponsive to established angiogenic factors . Positive_regulation PGC NOTCH3 24506866 2914234 Mechanistically , [PGC-1a] *induces* signaling , blunts activation of Rac/Akt/eNOS signaling , and renders endothelial cells unresponsive to established angiogenic factors . Positive_regulation PGC NOTCH4 24506866 2914235 Mechanistically , [PGC-1a] *induces* signaling , blunts activation of Rac/Akt/eNOS signaling , and renders endothelial cells unresponsive to established angiogenic factors . Positive_regulation PGC PIM3 21187426 2378912 We identify an important *role* for in modulating c-Myc and [PGC-1a] protein levels and cell growth . Positive_regulation PGC PLP1 25197313 2958075 Regarding mRNA expression , mainly *promoted* the expression of CPT-1 , [PGC1a] , UCP-1 , and AMPK in the mitochondria , whereas FB mostly enhanced the expression of Ech1 , Acox1 , Acaa1 , and Ehhadh in peroxisomes . Positive_regulation PGC POLDIP2 11481440 843692 Activation of the MAPK *enhances* the activity of wild-type [PGC-1] but not of a PGC-1 variant that no longer interacts with the repressor . Positive_regulation PGC POLDIP2 22496244 2613166 These results question the existence of reduced ß-adrenergic responsiveness in diet induced obesity and demonstrate that increases in phosphorylation are not *required* for induction of [PGC-1a] in muscle from obese rats . Positive_regulation PGC PPARA 10669761 666582 Retroviral vector mediated expression studies performed in 3T3-L1 cells demonstrated that PPARalpha and [PGC-1] cooperatively *induced* the expression of target genes and increased cellular palmitate oxidation rates . Positive_regulation PGC PPRC1 23927032 2844987 In the brain , PGC-1a and [PGC-1ß] were unchanged , but expression and mitochondrial DNA copy number *increased* . Positive_regulation PGC PRDM16 22033933 2516797 ( PRD1-BF1-RIZ1 homologous domain containing 16 ) *promoted* PPARa induction of [PGC-1a] gene transcription , especially under conditions in which protein kinase A pathways were activated . Positive_regulation PGC PRKAA1 16364253 1504759 Here we show that activation by 5-aminoimidazole-4-carboxamide ribonucleoside ( AICAR ) *increases* mRNA expression of PPARalpha target genes and [PGC-1] in cultured muscle cells and mouse skeletal muscle , and that inhibition of PPARalpha and PGC-1 by siRNAs prevents AICAR stimulated increase in fatty acid oxidation . Positive_regulation PGC PRKAA1 20643772 2316870 Nitric oxide and cooperatively *regulate* [PGC-1] in skeletal muscle cells . Positive_regulation PGC PRKAA1 21803289 2462283 Deletion of mIndy in mice ( mINDY ( -/- ) mice ) reduces hepatocellular ATP/ADP ratio , activates hepatic , *induces* [PGC-1a] , inhibits ACC-2 , and reduces SREBP-1c levels . Positive_regulation PGC PRKAA1 21814795 2538984 The constant activation of polyamine catabolism produces a futile cycle that greatly reduces the ATP pools and induces <5'-AMP activated protein kinase (AMPK)> , which in turn *activates* [PGC-1a] in WAT . Positive_regulation PGC PRKAA1 21862727 2510289 phosphorylation increased to a greater extent in the R-leg , and AICAR stimulation of cultured human myotubes *induced* the expression of [PGC-1a-a] and PGC-1a-b . Positive_regulation PGC PRKAA1 23090186 2717177 Resveratrol also lowered the NEFA and triacylglycerol content of the kidney , and this action was related to increases in the phosphorylation of and the *activation* of [SIRT1-PGC-1a] signalling and of the key downstream effectors , the PPARa-oestrogen related receptor ( ERR ) -1a-sterol regulatory element binding protein 1 ( SREBP1 ) . Positive_regulation PGC PRKAA1 23090186 2717201 Resveratrol prevented high-glucose induced oxidative stress and apoptosis in cultured mesangial cells through the phosphorylation of and *activation* of [SIRT1-PGC-1a] signalling and the downstream effectors , PPARa-ERR-1a-SREBP1 . Positive_regulation PGC PRKAA1 23090186 2717225 The results suggest that resveratrol prevents diabetic nephropathy in db/db mice by the phosphorylation of and *activation* of [SIRT1-PGC-1a] signalling , which appear to prevent lipotoxicity related apoptosis and oxidative stress in the kidney . Positive_regulation PGC PRKAA1 23963743 2916040 The purpose of the present investigation was to evaluate the *role* of in regulating [PGC-1a] and mitochondrial enzymes in mouse epididymal and inguinal subcutaneous adipose tissue . Positive_regulation PGC PRKAA1 23963743 2916052 Norepinephrine- and CL 316,243 mediated induction of [PGC-1a] and mitochondrial protein expression is *regulated* by in epididymal , but not inguinal adipose tissue . Positive_regulation PGC PRKAA2 16364253 1504760 Here we show that activation by 5-aminoimidazole-4-carboxamide ribonucleoside ( AICAR ) *increases* mRNA expression of PPARalpha target genes and [PGC-1] in cultured muscle cells and mouse skeletal muscle , and that inhibition of PPARalpha and PGC-1 by siRNAs prevents AICAR stimulated increase in fatty acid oxidation . Positive_regulation PGC PRKAA2 20643772 2316871 Nitric oxide and cooperatively *regulate* [PGC-1] in skeletal muscle cells . Positive_regulation PGC PRKAA2 21803289 2462284 Deletion of mIndy in mice ( mINDY ( -/- ) mice ) reduces hepatocellular ATP/ADP ratio , activates hepatic , *induces* [PGC-1a] , inhibits ACC-2 , and reduces SREBP-1c levels . Positive_regulation PGC PRKAA2 21814795 2538985 The constant activation of polyamine catabolism produces a futile cycle that greatly reduces the ATP pools and induces <5'-AMP activated protein kinase (AMPK)> , which in turn *activates* [PGC-1a] in WAT . Positive_regulation PGC PRKAA2 21862727 2510290 phosphorylation increased to a greater extent in the R-leg , and AICAR stimulation of cultured human myotubes *induced* the expression of PGC-1a-a and [PGC-1a-b] . Positive_regulation PGC PRKAA2 23090186 2717178 Resveratrol also lowered the NEFA and triacylglycerol content of the kidney , and this action was related to increases in the phosphorylation of and the *activation* of [SIRT1-PGC-1a] signalling and of the key downstream effectors , the PPARa-oestrogen related receptor ( ERR ) -1a-sterol regulatory element binding protein 1 ( SREBP1 ) . Positive_regulation PGC PRKAA2 23090186 2717202 Resveratrol prevented high-glucose induced oxidative stress and apoptosis in cultured mesangial cells through the phosphorylation of and *activation* of [SIRT1-PGC-1a] signalling and the downstream effectors , PPARa-ERR-1a-SREBP1 . Positive_regulation PGC PRKAA2 23090186 2717226 The results suggest that resveratrol prevents diabetic nephropathy in db/db mice by the phosphorylation of and *activation* of [SIRT1-PGC-1a] signalling , which appear to prevent lipotoxicity related apoptosis and oxidative stress in the kidney . Positive_regulation PGC PRKAA2 23963743 2916041 The purpose of the present investigation was to evaluate the *role* of in regulating [PGC-1a] and mitochondrial enzymes in mouse epididymal and inguinal subcutaneous adipose tissue . Positive_regulation PGC PRKAA2 23963743 2916053 Norepinephrine- and CL 316,243 mediated induction of [PGC-1a] and mitochondrial protein expression is *regulated* by in epididymal , but not inguinal adipose tissue . Positive_regulation PGC PRKAB1 16364253 1504761 Here we show that activation by 5-aminoimidazole-4-carboxamide ribonucleoside ( AICAR ) *increases* mRNA expression of PPARalpha target genes and [PGC-1] in cultured muscle cells and mouse skeletal muscle , and that inhibition of PPARalpha and PGC-1 by siRNAs prevents AICAR stimulated increase in fatty acid oxidation . Positive_regulation PGC PRKAB1 20643772 2316872 Nitric oxide and cooperatively *regulate* [PGC-1] in skeletal muscle cells . Positive_regulation PGC PRKAB1 21803289 2462285 Deletion of mIndy in mice ( mINDY ( -/- ) mice ) reduces hepatocellular ATP/ADP ratio , activates hepatic , *induces* [PGC-1a] , inhibits ACC-2 , and reduces SREBP-1c levels . Positive_regulation PGC PRKAB1 21814795 2538986 The constant activation of polyamine catabolism produces a futile cycle that greatly reduces the ATP pools and induces <5'-AMP activated protein kinase (AMPK)> , which in turn *activates* [PGC-1a] in WAT . Positive_regulation PGC PRKAB1 21862727 2510291 phosphorylation increased to a greater extent in the R-leg , and AICAR stimulation of cultured human myotubes *induced* the expression of [PGC-1a-a] and PGC-1a-b . Positive_regulation PGC PRKAB1 23090186 2717179 Resveratrol also lowered the NEFA and triacylglycerol content of the kidney , and this action was related to increases in the phosphorylation of and the *activation* of [SIRT1-PGC-1a] signalling and of the key downstream effectors , the PPARa-oestrogen related receptor ( ERR ) -1a-sterol regulatory element binding protein 1 ( SREBP1 ) . Positive_regulation PGC PRKAB1 23090186 2717203 Resveratrol prevented high-glucose induced oxidative stress and apoptosis in cultured mesangial cells through the phosphorylation of and *activation* of [SIRT1-PGC-1a] signalling and the downstream effectors , PPARa-ERR-1a-SREBP1 . Positive_regulation PGC PRKAB1 23090186 2717227 The results suggest that resveratrol prevents diabetic nephropathy in db/db mice by the phosphorylation of and *activation* of [SIRT1-PGC-1a] signalling , which appear to prevent lipotoxicity related apoptosis and oxidative stress in the kidney . Positive_regulation PGC PRKAB1 23963743 2916042 The purpose of the present investigation was to evaluate the *role* of in regulating [PGC-1a] and mitochondrial enzymes in mouse epididymal and inguinal subcutaneous adipose tissue . Positive_regulation PGC PRKAB1 23963743 2916054 Norepinephrine- and CL 316,243 mediated induction of [PGC-1a] and mitochondrial protein expression is *regulated* by in epididymal , but not inguinal adipose tissue . Positive_regulation PGC PRKAB2 16364253 1504762 Here we show that activation by 5-aminoimidazole-4-carboxamide ribonucleoside ( AICAR ) *increases* mRNA expression of PPARalpha target genes and [PGC-1] in cultured muscle cells and mouse skeletal muscle , and that inhibition of PPARalpha and PGC-1 by siRNAs prevents AICAR stimulated increase in fatty acid oxidation . Positive_regulation PGC PRKAB2 20643772 2316873 Nitric oxide and cooperatively *regulate* [PGC-1] in skeletal muscle cells . Positive_regulation PGC PRKAB2 21803289 2462286 Deletion of mIndy in mice ( mINDY ( -/- ) mice ) reduces hepatocellular ATP/ADP ratio , activates hepatic , *induces* [PGC-1a] , inhibits ACC-2 , and reduces SREBP-1c levels . Positive_regulation PGC PRKAB2 21814795 2538987 The constant activation of polyamine catabolism produces a futile cycle that greatly reduces the ATP pools and induces <5'-AMP activated protein kinase (AMPK)> , which in turn *activates* [PGC-1a] in WAT . Positive_regulation PGC PRKAB2 21862727 2510292 phosphorylation increased to a greater extent in the R-leg , and AICAR stimulation of cultured human myotubes *induced* the expression of PGC-1a-a and [PGC-1a-b] . Positive_regulation PGC PRKAB2 23090186 2717180 Resveratrol also lowered the NEFA and triacylglycerol content of the kidney , and this action was related to increases in the phosphorylation of and the *activation* of [SIRT1-PGC-1a] signalling and of the key downstream effectors , the PPARa-oestrogen related receptor ( ERR ) -1a-sterol regulatory element binding protein 1 ( SREBP1 ) . Positive_regulation PGC PRKAB2 23090186 2717204 Resveratrol prevented high-glucose induced oxidative stress and apoptosis in cultured mesangial cells through the phosphorylation of and *activation* of [SIRT1-PGC-1a] signalling and the downstream effectors , PPARa-ERR-1a-SREBP1 . Positive_regulation PGC PRKAB2 23090186 2717228 The results suggest that resveratrol prevents diabetic nephropathy in db/db mice by the phosphorylation of and *activation* of [SIRT1-PGC-1a] signalling , which appear to prevent lipotoxicity related apoptosis and oxidative stress in the kidney . Positive_regulation PGC PRKAB2 23963743 2916043 The purpose of the present investigation was to evaluate the *role* of in regulating [PGC-1a] and mitochondrial enzymes in mouse epididymal and inguinal subcutaneous adipose tissue . Positive_regulation PGC PRKAB2 23963743 2916055 Norepinephrine- and CL 316,243 mediated induction of [PGC-1a] and mitochondrial protein expression is *regulated* by in epididymal , but not inguinal adipose tissue . Positive_regulation PGC PRKACB 20670916 2298488 The cAMP induced inhibition of HNF-4alpha in COS-1 cells was counteracted by overexpression of the nuclear receptor coactivator PGC-1alpha , and dependent *induction* of the [PGC1A] gene in HepG2 cells seems to explain the cell specific differences . Positive_regulation PGC PRKACB 22767158 2676374 hesperetin activates PI-3 K , , PKC , ERK1 and CREB , and it *induces* PI-3 K , PKA , [PGC-1a] and seladin-1 via both ER and TrkA ; Positive_regulation PGC PRKACB 22767158 2676446 any inhibitor of PI-3 K , or PKC effectively *suppresses* the activation of ERK1 and CREB as well as the induction of [PGC-1a] and seladin-1 ; Positive_regulation PGC PRKACG 20670916 2298489 The cAMP induced inhibition of HNF-4alpha in COS-1 cells was counteracted by overexpression of the nuclear receptor coactivator PGC-1alpha , and dependent *induction* of the [PGC1A] gene in HepG2 cells seems to explain the cell specific differences . Positive_regulation PGC PRKACG 22767158 2676375 hesperetin activates PI-3 K , , PKC , ERK1 and CREB , and it *induces* PI-3 K , PKA , [PGC-1a] and seladin-1 via both ER and TrkA ; Positive_regulation PGC PRKACG 22767158 2676447 any inhibitor of PI-3 K , or PKC effectively *suppresses* the activation of ERK1 and CREB as well as the induction of [PGC-1a] and seladin-1 ; Positive_regulation PGC PRKAG1 16364253 1504763 Here we show that activation by 5-aminoimidazole-4-carboxamide ribonucleoside ( AICAR ) *increases* mRNA expression of PPARalpha target genes and [PGC-1] in cultured muscle cells and mouse skeletal muscle , and that inhibition of PPARalpha and PGC-1 by siRNAs prevents AICAR stimulated increase in fatty acid oxidation . Positive_regulation PGC PRKAG1 20643772 2316874 Nitric oxide and cooperatively *regulate* [PGC-1] in skeletal muscle cells . Positive_regulation PGC PRKAG1 21803289 2462287 Deletion of mIndy in mice ( mINDY ( -/- ) mice ) reduces hepatocellular ATP/ADP ratio , activates hepatic , *induces* [PGC-1a] , inhibits ACC-2 , and reduces SREBP-1c levels . Positive_regulation PGC PRKAG1 21814795 2538988 The constant activation of polyamine catabolism produces a futile cycle that greatly reduces the ATP pools and induces <5'-AMP activated protein kinase (AMPK)> , which in turn *activates* [PGC-1a] in WAT . Positive_regulation PGC PRKAG1 21862727 2510293 phosphorylation increased to a greater extent in the R-leg , and AICAR stimulation of cultured human myotubes *induced* the expression of PGC-1a-a and [PGC-1a-b] . Positive_regulation PGC PRKAG1 23090186 2717181 Resveratrol also lowered the NEFA and triacylglycerol content of the kidney , and this action was related to increases in the phosphorylation of and the *activation* of [SIRT1-PGC-1a] signalling and of the key downstream effectors , the PPARa-oestrogen related receptor ( ERR ) -1a-sterol regulatory element binding protein 1 ( SREBP1 ) . Positive_regulation PGC PRKAG1 23090186 2717205 Resveratrol prevented high-glucose induced oxidative stress and apoptosis in cultured mesangial cells through the phosphorylation of and *activation* of [SIRT1-PGC-1a] signalling and the downstream effectors , PPARa-ERR-1a-SREBP1 . Positive_regulation PGC PRKAG1 23090186 2717229 The results suggest that resveratrol prevents diabetic nephropathy in db/db mice by the phosphorylation of and *activation* of [SIRT1-PGC-1a] signalling , which appear to prevent lipotoxicity related apoptosis and oxidative stress in the kidney . Positive_regulation PGC PRKAG1 23963743 2916044 The purpose of the present investigation was to evaluate the *role* of in regulating [PGC-1a] and mitochondrial enzymes in mouse epididymal and inguinal subcutaneous adipose tissue . Positive_regulation PGC PRKAG1 23963743 2916056 Norepinephrine- and CL 316,243 mediated induction of [PGC-1a] and mitochondrial protein expression is *regulated* by in epididymal , but not inguinal adipose tissue . Positive_regulation PGC PRKAG2 16364253 1504764 Here we show that activation by 5-aminoimidazole-4-carboxamide ribonucleoside ( AICAR ) *increases* mRNA expression of PPARalpha target genes and [PGC-1] in cultured muscle cells and mouse skeletal muscle , and that inhibition of PPARalpha and PGC-1 by siRNAs prevents AICAR stimulated increase in fatty acid oxidation . Positive_regulation PGC PRKAG2 20643772 2316875 Nitric oxide and cooperatively *regulate* [PGC-1] in skeletal muscle cells . Positive_regulation PGC PRKAG2 21803289 2462288 Deletion of mIndy in mice ( mINDY ( -/- ) mice ) reduces hepatocellular ATP/ADP ratio , activates hepatic , *induces* [PGC-1a] , inhibits ACC-2 , and reduces SREBP-1c levels . Positive_regulation PGC PRKAG2 21814795 2538989 The constant activation of polyamine catabolism produces a futile cycle that greatly reduces the ATP pools and induces <5'-AMP activated protein kinase (AMPK)> , which in turn *activates* [PGC-1a] in WAT . Positive_regulation PGC PRKAG2 21862727 2510294 phosphorylation increased to a greater extent in the R-leg , and AICAR stimulation of cultured human myotubes *induced* the expression of [PGC-1a-a] and PGC-1a-b . Positive_regulation PGC PRKAG2 23090186 2717182 Resveratrol also lowered the NEFA and triacylglycerol content of the kidney , and this action was related to increases in the phosphorylation of and the *activation* of [SIRT1-PGC-1a] signalling and of the key downstream effectors , the PPARa-oestrogen related receptor ( ERR ) -1a-sterol regulatory element binding protein 1 ( SREBP1 ) . Positive_regulation PGC PRKAG2 23090186 2717206 Resveratrol prevented high-glucose induced oxidative stress and apoptosis in cultured mesangial cells through the phosphorylation of and *activation* of [SIRT1-PGC-1a] signalling and the downstream effectors , PPARa-ERR-1a-SREBP1 . Positive_regulation PGC PRKAG2 23090186 2717230 The results suggest that resveratrol prevents diabetic nephropathy in db/db mice by the phosphorylation of and *activation* of [SIRT1-PGC-1a] signalling , which appear to prevent lipotoxicity related apoptosis and oxidative stress in the kidney . Positive_regulation PGC PRKAG2 23963743 2916045 The purpose of the present investigation was to evaluate the *role* of in regulating [PGC-1a] and mitochondrial enzymes in mouse epididymal and inguinal subcutaneous adipose tissue . Positive_regulation PGC PRKAG2 23963743 2916057 Norepinephrine- and CL 316,243 mediated induction of [PGC-1a] and mitochondrial protein expression is *regulated* by in epididymal , but not inguinal adipose tissue . Positive_regulation PGC PRKAR1A 20670916 2298490 The cAMP induced inhibition of HNF-4alpha in COS-1 cells was counteracted by overexpression of the nuclear receptor coactivator PGC-1alpha , and dependent *induction* of the [PGC1A] gene in HepG2 cells seems to explain the cell specific differences . Positive_regulation PGC PRKAR1A 22767158 2676376 hesperetin activates PI-3 K , , PKC , ERK1 and CREB , and it *induces* PI-3 K , PKA , [PGC-1a] and seladin-1 via both ER and TrkA ; Positive_regulation PGC PRKAR1A 22767158 2676448 any inhibitor of PI-3 K , or PKC effectively *suppresses* the activation of ERK1 and CREB as well as the induction of [PGC-1a] and seladin-1 ; Positive_regulation PGC PRKAR1B 20670916 2298491 The cAMP induced inhibition of HNF-4alpha in COS-1 cells was counteracted by overexpression of the nuclear receptor coactivator PGC-1alpha , and dependent *induction* of the [PGC1A] gene in HepG2 cells seems to explain the cell specific differences . Positive_regulation PGC PRKAR1B 22767158 2676377 hesperetin activates PI-3 K , , PKC , ERK1 and CREB , and it *induces* PI-3 K , PKA , [PGC-1a] and seladin-1 via both ER and TrkA ; Positive_regulation PGC PRKAR1B 22767158 2676449 any inhibitor of PI-3 K , or PKC effectively *suppresses* the activation of ERK1 and CREB as well as the induction of [PGC-1a] and seladin-1 ; Positive_regulation PGC PRKAR2A 20670916 2298492 The cAMP induced inhibition of HNF-4alpha in COS-1 cells was counteracted by overexpression of the nuclear receptor coactivator PGC-1alpha , and dependent *induction* of the [PGC1A] gene in HepG2 cells seems to explain the cell specific differences . Positive_regulation PGC PRKAR2A 22767158 2676378 hesperetin activates PI-3 K , , PKC , ERK1 and CREB , and it *induces* PI-3 K , PKA , [PGC-1a] and seladin-1 via both ER and TrkA ; Positive_regulation PGC PRKAR2A 22767158 2676450 any inhibitor of PI-3 K , or PKC effectively *suppresses* the activation of ERK1 and CREB as well as the induction of [PGC-1a] and seladin-1 ; Positive_regulation PGC PRKAR2B 20670916 2298493 The cAMP induced inhibition of HNF-4alpha in COS-1 cells was counteracted by overexpression of the nuclear receptor coactivator PGC-1alpha , and dependent *induction* of the [PGC1A] gene in HepG2 cells seems to explain the cell specific differences . Positive_regulation PGC PRKAR2B 22767158 2676379 hesperetin activates PI-3 K , , PKC , ERK1 and CREB , and it *induces* PI-3 K , PKA , [PGC-1a] and seladin-1 via both ER and TrkA ; Positive_regulation PGC PRKAR2B 22767158 2676451 any inhibitor of PI-3 K , or PKC effectively *suppresses* the activation of ERK1 and CREB as well as the induction of [PGC-1a] and seladin-1 ; Positive_regulation PGC RBBP8 17089023 1644235 We further demonstrated that the overexpression of *resulted* in changes in the expression of the [PGC-1] responsive gene , fatty acid synthase (FAS) . Positive_regulation PGC RBP4 23300015 2818400 The cyclic adenosine monophosphate ( cAMP ) -response element binding protein ( CREB ) was identified as the target transcription factor involved in the *mediated* up-regulation of [PGC-1ß] transcription as a result of phosphorylation on Ser133 . Positive_regulation PGC SIRT1 20929977 2368935 Parallel to this , we observed AMPK activation , [PGC-1a] deacetylation , and *induction* in trained wild-type mice . Positive_regulation PGC SIRT1 21212096 2386308 Increases in gluconeogenesis , Hmgcr , Acc , and cholesterol were abolished by SIRT1 inhibitors and rotenone , while activators *increased* gluconeogenesis , Hmgcr , Acc , [Pgc1ß] , and sterol regulatory element binding protein 1c ( Srebp1c ) gene expression . Positive_regulation PGC SIRT1 21874557 2510399 Parallel to these changes , we observed AMPK activation , *induction* and [PGC-1a] deacetylation . Positive_regulation PGC SIRT1 21888529 2491580 Further research examining exercise mediated activation of and the *role* of GCN5 in regulating [PGC-1a] transcriptional activity in skeletal muscle is required . Positive_regulation PGC SIRT1 22492282 2522530 Analysis of muscle-specific AdipoR1 knockout mice revealed the pivotal role of adiponectin/AdipoR1 in the regulation of mitochondrial biogenesis via AMPK- and mediated [PGC-1a] *activation* as well as Ca ( 2+ ) -dependent up-regulation of PGC-1a expression . Positive_regulation PGC SIRT1 22892143 2672014 We demonstrate that nitrite significantly increases cellular mitochondrial number by augmenting the activity of adenylate kinase , resulting in AMP kinase phosphorylation , downstream *activation* of , and deacetylation of [PGC1a] , the master regulator of mitochondrial biogenesis . Positive_regulation PGC SIRT1 23525928 2787928 Collectively , we demonstrate that the *dependent* [PGC-1a] subcellular translocation following resveratrol application potentially attenuates serum deprivation elicited RGC-5 cell death , thereby raising the possibility of mitigating glaucomatous retinopathy by enhancement of mitochondrial biogenesis . Positive_regulation PGC SIRT1 24870244 2945651 The histone acetyltransferase GCN5 ( general control non repressed protein 5 ) acetylates PGC-1a and suppresses its transcriptional activity , whereas deacetylates and *activates* [PGC-1a] . Positive_regulation PGC SOX2 17136346 1693661 Over-expression of *up-regulated* expression of pepsinogen A but not that of [pepsinogen C] in 293T human embryonic kidney cells , and some GC and CRC cell lines . Positive_regulation PGC SREBF1 21803289 2462281 Deletion of mIndy in mice ( mINDY ( -/- ) mice ) reduces hepatocellular ATP/ADP ratio , activates hepatic AMPK , *induces* [PGC-1a] , inhibits ACC-2 , and reduces levels . Positive_regulation PGC TERT 21307849 2393306 In the setting of telomere dysfunction , enforced or PGC-1a expression or germline deletion of p53 ( also known as Trp53 ) substantially *restores* [PGC] network expression , mitochondrial respiration , cardiac function and gluconeogenesis . Positive_regulation PGC TNF 22343369 2606082 Atorvastatin attenuates *induced* increase of glucose oxidation through [PGC-1a] upregulation in cardiomyocytes . Positive_regulation PGC TNF 24654751 2942827 [PGC-1a] expression was *enhanced* in SCs from OE by ( P < .05 ) but not by hypoxia or 17ß-estradiol . Positive_regulation PGC TNFRSF12A 23342071 2733891 Selective targeting of the *dependent* signaling pathway or augmenting [PGC1a] levels may serve as novel therapeutic strategies for cardiomyopathy and heart failure . Positive_regulation PGC TRAF2 23342071 2733890 Selective targeting of the *dependent* signaling pathway or augmenting [PGC1a] levels may serve as novel therapeutic strategies for cardiomyopathy and heart failure . Positive_regulation PGC TRO 20860658 2325951 , but not Rosi or Pio , selectively *stimulated* [PGC-1a] protein degradation . Positive_regulation PGC TRPV4 23021218 2679466 In particular , negatively *regulated* the expression of [PGC1a] , UCP1 , and cellular respiration . Positive_regulation PGC TWIST1 23093952 2690818 Transcriptional Activity of [PGC-1a] and NT-PGC-1a Is Differentially *Regulated* by in Brown Fat Metabolism . Positive_regulation PGC TXN 16987018 1617755 Expression of NRF1 and [PGC-1gamma] was upregulated in Tg-Trx1 , and *stimulated* the transcriptional activity of NRF1 and NRF2 in cardiac myocytes . Positive_regulation PGC UCP1 22561685 2631940 Rald induced uncoupling protein-1 (Ucp1) mRNA and protein levels in white adipocytes by selectively activating the retinoic acid receptor ( RAR ) , recruiting the coactivator [PGC-1a] and *inducing* promoter activity . Positive_regulation PGC UCP2 22500511 2583902 PIO *induced* a 2-fold increase in UCP-2 and nuclear bound [PGC1a] in WT mice with no expression in KO mice . Positive_regulation PGC UTRN 24447845 2912974 We show here that [PGC-1ß] does not *induce* or other neuromuscular genes when transgenically expressed in mouse skeletal muscle . Positive_regulation PGC VEGFA 21364124 2443454 [PGC-1ß] *induces* the expression of vascular endothelial growth factor ( ) in cell culture and in vivo . Positive_regulation PGC VEGFA 23141926 2717874 In skeletal muscle , [PGC-1a] *induces* expression and powerfully promotes angiogenesis , suggesting a similar role in other tissues . Positive_regulation PGC VEGFA 24505137 2928419 [NT-PGC-1a] strongly *induces* expression , whereas having little effect on mitochondrial genes . Positive_regulation PGC WNT1 22232553 2563964 Brown adipose tissue insulin sensitivity and reduced adiposity of LRP6 ( +/- ) mice were accounted for by diminished *dependent* mTORC1 activity and enhanced expression of brown adipose tissue [PGC1-a] and UCP1 . Positive_regulation PGC WNT11 22232553 2563965 Brown adipose tissue insulin sensitivity and reduced adiposity of LRP6 ( +/- ) mice were accounted for by diminished *dependent* mTORC1 activity and enhanced expression of brown adipose tissue [PGC1-a] and UCP1 . Positive_regulation PGC WNT16 22232553 2563970 Brown adipose tissue insulin sensitivity and reduced adiposity of LRP6 ( +/- ) mice were accounted for by diminished *dependent* mTORC1 activity and enhanced expression of brown adipose tissue [PGC1-a] and UCP1 . Positive_regulation PGC WNT2 22232553 2563966 Brown adipose tissue insulin sensitivity and reduced adiposity of LRP6 ( +/- ) mice were accounted for by diminished *dependent* mTORC1 activity and enhanced expression of brown adipose tissue [PGC1-a] and UCP1 . Positive_regulation PGC WNT3 22232553 2563967 Brown adipose tissue insulin sensitivity and reduced adiposity of LRP6 ( +/- ) mice were accounted for by diminished *dependent* mTORC1 activity and enhanced expression of brown adipose tissue [PGC1-a] and UCP1 . Positive_regulation PGC WNT4 22232553 2563968 Brown adipose tissue insulin sensitivity and reduced adiposity of LRP6 ( +/- ) mice were accounted for by diminished *dependent* mTORC1 activity and enhanced expression of brown adipose tissue [PGC1-a] and UCP1 . Positive_regulation PGC WNT6 22232553 2563969 Brown adipose tissue insulin sensitivity and reduced adiposity of LRP6 ( +/- ) mice were accounted for by diminished *dependent* mTORC1 activity and enhanced expression of brown adipose tissue [PGC1-a] and UCP1 . Positive_regulation PGD ALOX5 8500985 220933 The cyclooxygenase inhibitor , indomethacin , and the specific <5-lipoxygenase> inhibitor , L-651,392 completely *inhibited* [PGD2] and LTC4/D4 generation , respectively , without affecting release of other mediators . Positive_regulation PGD IL1B 16423868 1533934 In Sertoli epithelial cells , the *induces* prostaglandins ( PG ) PGE ( 2 ) , PGF ( 2alpha ) and PGI ( 2 ) ( 7- , 11- , and 2-fold , respectively ) , but not [PGD] ( 2 ) , production . Positive_regulation PGD IL1B 18598759 1972269 Exogenous NO augmented COX-2 protein expression and increased COX-2 dependent [PGD] ( 2 ) generation in *response* to SCF , IL-10 , and , or antigen activation in combination with IL-10 and IL-1beta after sensitization with IgE . Positive_regulation PGD IL1B 8954964 401095 These results suggest that , of the three PLA2s expressed in BMMC , type II sPLA2 is the critical enzyme that is coupled with COX-2 dependent [PGD2] generation elicited by IgE/Ag in the *presence* of IL-10 + . Positive_regulation PGD IL1B 8982097 403791 Among these cytokines , only significantly *stimulated* production of prostaglandins E2 and F2 alpha but not [PGD2] , thromboxane B2 and 6-keto-PGF1 alpha . Positive_regulation PGD TNF 18996481 2001420 *increased* [PGD2] levels which were enhanced by 7beta-OH-EPIA . Positive_regulation PGD TNF 22922824 2672502 The impact increased the release of PGE2 and [PGD2] in the *presence* and absence of to a similar extent while TNF-a alone showed no effect . Positive_regulation PGF ARSA 12711246 1083226 D-003 and ASA monotherapies reduced serum TxB ( 2 ) levels , whereas D-003 , but not , significantly *increased* 6 keto [PgF1alpha] levels . Positive_regulation PGF EPHB2 20536573 2271623 [PGF] ( 2alpha ) *induced* both and CREB/ATF-1 phosphorylation in pulp cells . Positive_regulation PGF IL1B 11327082 807525 IL-6 mRNA was expressed in PGF2alpha stimulated HGF , and [PGF2alpha] increased IL-6 mRNA levels *induced* by and TNFalpha . Positive_regulation PGF IL1B 11585122 865979 Northern blot analysis revealed that PGF2alpha enhanced MMP-1 mRNA expression in HGF and that [PGF2alpha] increased MMP-1 mRNA levels *induced* by . Positive_regulation PGF IL1B 14611637 1162786 In rats , PGF ( 2alpha ) and are *involved* in structural luteolysis , [PGF] ( 2alpha ) by increasing ovarian lipid peroxidation , and IL-1beta by reducing progesterone and increasing PGF ( 2alpha ) concentrations . Positive_regulation PGF IL1B 15840748 1425472 and TNFalpha *caused* concentration dependent increases in [9alpha,11beta-PGF] ( 2 ) production in human amnion and choriodecidual explants . Positive_regulation PGF IL1B 16556676 1562118 By contrast , with the existing known human endometrial cell lines Ishikawa and KLE , HIESC and HIEEC increase their production of [PGF2alpha] and PGE2 and cyclooxygenase (COX)-2 protein expression in *response* to . Positive_regulation PGF IL1B 18824521 1987708 Cultured bovine epithelial and stromal cells were exposed to IL1A or IL1B ( 0.006-3.0 nM ) for 24 h . IL1A and dose-dependently *stimulated* PGE2 and [PGF2alpha] production in the stromal cells , but not in the epithelial cells . Positive_regulation PGF IL1B 19345795 2057460 We found that *stimulated* [PGF] ( 2alpha ) production of human dental pulp cells . Positive_regulation PGF IL1B 19345795 2057464 Aspirin inhibited *induced* [PGF] ( 2alpha ) , but not IL-8 production . Positive_regulation PGF IL1B 19374865 2065504 We show that PPAR activators , as well as liver X receptor alpha , farnesoid X receptor and retinoid X receptor alpha activators , inhibit *induced* SMC 6-keto [PGF1alpha] synthesis , an index of cyclooxygenase (COX)-2 activity , with IC ( 50 ) between 1 and 69 microM . Positive_regulation PGF IL1B 8939002 398450 significantly *stimulated* the production of [PGF] only . Positive_regulation PGF IL1B 9047011 416727 In contrast , significantly *stimulated* [PGF2] alpha production in a dose dependent manner during the mid and late luteal phases ( p < 0.05 ) . Positive_regulation PGF IL1B 9551670 477819 *stimulated* [PGF2alpha] in luteal and luteal plus accessory cells , and tended to elevate PGF2alpha in accessory cells . Positive_regulation PGF IL1B 9551670 477820 Indomethacin inhibited the *stimulated* [PGF2alpha] and PGE2 release . Positive_regulation PGF MMP28 11870075 918322 The objectives of these experiments were to determine whether 1 ) [PGF] ( 2 alpha ) affects expression of mRNA encoding fibrillar collagenases ( MMP-1 and -13 ) , gelatinases A and B ( MMP-2 and -9 ) , membrane type (mt)-1 MMP ( MMP-14 ) , stromelysin ( MMP-3 ) , and matrilysin ( MMP-7 ) , and 2 ) PGF ( 2 alpha ) *increases* activity during PGF ( 2 alpha ) -induced luteolysis in sheep . Positive_regulation PGF MMP7 11870075 918337 The objectives of these experiments were to determine whether 1 ) [PGF] ( 2 alpha ) affects expression of mRNA encoding fibrillar collagenases ( MMP-1 and -13 ) , gelatinases A and B ( MMP-2 and -9 ) , membrane type (mt)-1 MMP ( MMP-14 ) , stromelysin ( MMP-3 ) , and matrilysin ( MMP-7 ) , and 2 ) PGF ( 2 alpha ) *increases* activity during PGF ( 2 alpha ) -induced luteolysis in sheep . Positive_regulation PGF PLAU 10886518 709837 Similarly , [placenta growth factor] did not *induce* production in these cells . Positive_regulation PGF SLCO2A1 20962043 2348473 The results of the present study provide important new insights on IFNT signaling and molecular control of *mediated* release of [PGF] ( 2a ) and unravel the underlying mechanisms responsible for the increased basal release of PGF ( 2a ) at the time of establishment of pregnancy in ruminants . Positive_regulation PGF SLCO2A1 23759308 2843879 In conclusion , intrauterine inhibition of *inhibits* the pulsatile release of [PGF2] ( alpha ) from the endometrium without modulating spatial expressions of estrogen and oxytocin receptor proteins and metabolism of PGF2 ( alpha ) at the time of luteolysis . Positive_regulation PGF TNF 10775156 686505 The aims of the present study were to determine the cell types in the endometrium ( epithelial or stromal cells ) responsible for the secretion of [PGF] ( 2alpha ) in *response* to , and the intracellular mechanisms of TNFalpha action . Positive_regulation PGF TNF 10775156 686508 Cultured bovine epithelial and stromal cells were exposed to TNFalpha ( 0.006-6 nM ) or oxytocin ( 100 nM ) for 4 h . *resulted* in a dose dependent increase of [PGF] ( 2alpha ) production in the stromal cells ( P < 0.001 ) but not in the epithelial cells . Positive_regulation PGF TNF 10775156 686510 Although an NO synthase (NOS) inhibitor ( L-NAME ) reduced *stimulated* [PGF] ( 2alpha ) production , an inhibitor of phosphodiesterase augmented the actions of TNFalpha and S-NAP ( P < 0. 05 ) . Positive_regulation PGF TNF 10913228 716257 *enhanced* the [PGF2] alpha stimulated formation of inositol phosphates . Positive_regulation PGF TNF 11327082 807524 IL-6 mRNA was expressed in PGF2alpha stimulated HGF , and [PGF2alpha] increased IL-6 mRNA levels *induced* by IL-1beta and . Positive_regulation PGF TNF 11393218 823085 Although *stimulated* both PGE2 and [PGF2alpha] secretion during the entire period of the estrous cycle , the level of stimulation of TNFalpha on PGE2 output by the bovine endometrium does not show the same cyclical changes as that shown on PGF2alpha output . Positive_regulation PGF TNF 12142242 969540 Furthermore , our recent study has shown that IFN-tau suppresses the action of TNF-alpha on PGF ( 2alpha ) synthesis by the bovine endometrium in vitro , suggesting that IFN-tau plays a luteoprotective role by inhibiting *induced* [PGF] ( 2alpha ) production in early pregnancy . Positive_regulation PGF TNF 13679315 1185642 The aims of the present study were to determine the effect of interferon-tau ( IFNtau ) on *stimulated* [PGF2alpha] synthesis and the intracellular mechanisms of TNFalpha and IFNtau action in the stromal cells . Positive_regulation PGF TNF 13679315 1185644 When cultured bovine stromal cells were exposed to TNFalpha ( 0.006-0.6 nM ) for 24 h , the production of [PGF2alpha] and cyclooxygenase (COX)-2 gene expression were *stimulated* by ( 0.06-0.6 nM , P < 0.05 ) . Positive_regulation PGF TNF 14967905 1182629 In primary culture of frozen and unfrozen endometrial cells , OT strongly stimulated [PGF] ( 2alpha ) production in epithelial cells , and strongly *stimulated* PGF ( 2alpha ) production in stromal cells ( P < 0.05 ) . Positive_regulation PGF TNF 15840748 1425471 IL-1beta and *caused* concentration dependent increases in [9alpha,11beta-PGF] ( 2 ) production in human amnion and choriodecidual explants . Positive_regulation PGF TNF 16534415 1536546 Gi alpha2-/- myofibroblasts from the small intestine and colon both released asymptotically equal to 50 % less arachidonate and 3- to 7-fold less PGE2 and 6-keto [PGF1alpha] in *response* to adenosine triphosphate , thrombin , , or lipopolysaccharide , in a partially cyclooxygenase (COX)-2 dependent manner . Positive_regulation PGF TNF 17107518 1645099 Moreover , *increased* [PGF] ( 2alpha ) secretion from both endometrial cell types with effective concentrations of 1 ( p < 0.05 ) , 10 and 50 ng/ml ( p < 0.01 ) . Positive_regulation PGF TNF 17107518 1645101 Summarizing , induces both PGs secretion from cultured porcine endometrium , but preferentially *stimulates* [PGF] ( 2alpha ) release from luminal epithelial cells . Positive_regulation PGF TNF 1733731 181618 ( 1-1000 ng/ml ) produced a dose dependent *increase* in prostaglandin (PG)F2 alpha and [6-keto-PGF1] alpha synthesis on all days of culture , but had no effect on basal progesterone ( P4 ) production . Positive_regulation PGF TNF 1733731 181632 TNF-alpha , in combination with other known stimulators of luteal PG synthesis , interleukin-1 beta ( 2.5 ng/ml ) or interferon-gamma ( IFN-gamma , 100 U/ml ) , had synergistic effects on PGF2 alpha production ( greater than 50-fold above control , P less than 0.05 ) whereas interferon-alpha ( 1000 U/ml ) significantly suppressed *stimulated* [PGF2] alpha production . Positive_regulation PGF TNF 18564315 2113507 One microgram *increased* [PGF] ( 2alpha ) and NO ( p < 0.001 ) and decreased P4 ( p < 0.05 ) . Positive_regulation PGF TNF 21370737 2361334 at a dose of 1 ng/ml significantly *increased* [PGF2alpha] secretion at estrus ( P < 0.01 ) and PGE2 secretion at diestrus ( P < 0.001 ) after 12h incubation . Positive_regulation PGF TNF 21420267 2438335 The pretreatment of cells with P4 ( progesterone ) , E2 ( 17 ß-estradiol ) , or E2/P4 augmented *induced* [PGF] ( 2a ) and PGE2 secretion ( P < 0.01 ) . Positive_regulation PGF TNF 8948504 400588 Inhibitors of RNA and protein synthesis ( actinomycin D and cycloheximide , respectively ) completely blocked *stimulated* [PGF2] alpha production . Positive_regulation PGF TNF 8948504 400589 The phospholipase A2 inhibitor , aristolochic acid , prevented *stimulated* , but not basal , [PGF2] alpha production , whereas the phospholipase C inhibitor , compound 48/80 , was without effect . Positive_regulation PGM1 S100B 8894274 392361 In contrast , *stimulated* [phosphoglucomutase] activity in a calcium dependent manner . Positive_regulation PGM2 S100B 8894274 392362 In contrast , *stimulated* [phosphoglucomutase] activity in a calcium dependent manner . Positive_regulation PGM3 S100B 8894274 392363 In contrast , *stimulated* [phosphoglucomutase] activity in a calcium dependent manner . Positive_regulation PGM5 S100B 8894274 392364 In contrast , *stimulated* [phosphoglucomutase] activity in a calcium dependent manner . Positive_regulation PGP CAPN8 10493948 646910 These results indicated that involved Pgp turnover and that calpain inhibition *induced* ubiquitinated [Pgp-accumulation] mainly at the cell surface membrane with a reduction in its own functions suggesting that the modulation of Pgp-turnover involves MDR-reversal by another approach . Positive_regulation PGP S1PR3 17316399 1699831 Finally , we found that the S1P mediated stimulation of [P-gp] activity is *mediated* by S1P-1 and receptors at the RBE4 cell surface . Positive_regulation PGP SRGN 1348973 185834 *had* little effect on the binding of [ 3H ] -azidopine to [P-gp] . Positive_regulation PGP TNF 19384845 2069202 *restored* [Pgp] expression and function . Positive_regulation PGP TNF 19629677 2195056 also *increased* protein expression of [P-gp] but the uptake of the P-gp substrate rhodamine 123 was not affected by any of the cytokines . Positive_regulation PGP TNF 20300455 2224063 The signaling pathway through which lipopolysaccharide (LPS) or *regulates* [P-gp] expression and activity was investigated further in the present study . Positive_regulation PGP TNF 24028618 2842192 This report suggested that , ET-1 , NOS and PKC may *mediate* upregulation of [P-gp] in the rBMECs under OGD , which may be worthy of being referenced for the investigation of P-gp at the blood-brain barrier in the early period of stroke . Positive_regulation PGP TNF 24130926 2714735 In results of real time PCR analysis , the [P-gp] mRNA expression was *increased* by or IFN-? treatment for 24 hr in both cell types . Positive_regulation PGP TNF 7564516 324358 Recombinant cytokines including GM-CSF , G-CSF , IL-1 beta , IL-6 , stem cell factor , LIF , erythropoietin , and IL-3 had no effect on P-gp expression whereas *induced* dose- and time dependent [P-gp] and mdr-1 gene overexpression . Positive_regulation PGP TNF 7564516 324359 However , *induced* [P-gp] overexpression had no influence on P-gp efflux capacity . Positive_regulation PGR CCND1 20404095 2262357 *regulated* [progesterone receptor] expression through a novel estrogen- and cyclin D1-responsive enhancer in DNA encoding part of the 3 ' untranslated region of the progesterone receptor gene . Positive_regulation PGR EPHB2 17081988 1643158 Five minutes after hormone treatment , activation *leads* to phosphorylation of the [progesterone receptor (PR)] , activation of Msk1 , and recruitment of a complex of the three proteins to a nucleosome on the MMTV promoter . Positive_regulation PGR TNF 21784129 2476458 *induced* luciferase expression in the absence and presence of estradiol and also augmented expression of the estrogen regulated genes c-fos , GREB1 , and [progesterone receptor] . Positive_regulation PHB EPHB2 19725029 2183176 TGF-beta activation of intracellular signaling , *led* to [PHB] phosphorylation , decreased inner mitochondrial permeability , and increased cell survival . Positive_regulation PHC1 ZFP57 20808772 2314014 Levels of both and PcG proteins inversely correlated with those of reactive oxygen species ( ROS ) in senescing MEFs , but the treatment of Zfp277 ( -/- ) MEFs with an antioxidant *restored* the binding of PRC2 but not [PRC1] to the Ink4a/Arf locus . Positive_regulation PHEX TNF 16890604 1597045 The aim of this study was to evaluate whether *regulates* [Phex] gene expression thus contributing to the abnormal bone metabolism observed in IBD . Positive_regulation PHF17 CCND1 18399550 1893752 Overexpression of [ING4] can induce growth inhibition in A549 cells both in vitro and in vivo , and also *induce* up-regulation of p27 , down-regulation of , SKP2 , and Cox2 , and inactivation of the Wnt-1/beta-catenin pathway . Positive_regulation PHKA2 EDN2 15911746 1420301 We have investigated the role of the actin cytoskeleton in noradrenaline ( NA ) -induced and induced *activation* of the calcium dependent nonreceptor tyrosine kinase [PYK2] and subsequent phosphorylation of paxillin in rat small mesenteric arteries . Positive_regulation PHKA2 F2R 24025335 2857096 Inhibition or depletion of also *blocked* thrombin induced activation of [Pyk2] , Gab1 , p115 RhoGEF , Rac1 , RhoA , and Pak2 , resulting in diminished THP-1 cell F-actin cytoskeletal remodeling and migration . Positive_regulation PHKA2 GPR115 14963038 1235493 [Pyk2] is a member of the focal adhesion kinase family and can be *activated* by c-Src , epidermal growth factor receptor (EGFR) , Janus kinase 1 , tyrosine kinases , and signaling . Positive_regulation PHKA2 GPR115 9826186 550510 Further studies indicate that [Pyk2] phosphorylation , but not MAPK activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation PHKA2 GPR132 14963038 1235482 [Pyk2] is a member of the focal adhesion kinase family and can be *activated* by c-Src , epidermal growth factor receptor (EGFR) , Janus kinase 1 , tyrosine kinases , and signaling . Positive_regulation PHKA2 GPR132 9826186 550499 Further studies indicate that [Pyk2] phosphorylation , but not MAPK activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation PHKA2 GPR87 14963038 1235562 [Pyk2] is a member of the focal adhesion kinase family and can be *activated* by c-Src , epidermal growth factor receptor (EGFR) , Janus kinase 1 , tyrosine kinases , and signaling . Positive_regulation PHKA2 GPR87 9826186 550579 Further studies indicate that [Pyk2] phosphorylation , but not MAPK activation , is *dependent* on a pertussis toxin-sensitive as well as partially on actin cytoskeleton . Positive_regulation PHKA2 ITGB2 20805505 2318287 Thus , [PYK2] facilitates *dependent* CD8 T-cell responses and promotes CD8 T-cell short lived effector fate , suggesting that PYK2 may be an interesting therapeutic target to suppress exacerbated CD8 T-cell responses . Positive_regulation PHKA2 ITGB2 21270398 2392763 Whereas CD16 activated Ca ( 2+ ) mobilization and LAT phosphorylation , did not , but *induced* strong [Pyk2] and paxillin phosphorylation . Positive_regulation PHKA2 TLR7 12616494 1065687 PP2 , an inhibitor of Src family tyrosine kinases , prevented the *induced* phosphorylation of paxillin and [Pyk2] without affecting TLR induced IRAK activation . Positive_regulation PHKA2 TNF 23774252 2843951 In addition , *mediated* [PYK2] phosphorylation was inhibited by NAC , DPI , or APO . Positive_regulation PHKA2 TNF 23774252 2843953 We demonstrated that NADPH oxidase derived ROS generation is involved in *induced* [PYK2] activation in these cells . Positive_regulation PHLDA1 EPHB2 15037619 1251181 The , JNK , and phosphatidylinositol 3-kinase pathways were not *involved* in IGF-I induced regulation of [TDAG51] . Positive_regulation PHOSPHO1 TNF 14695331 1195041 [Phospho-MKK3] levels were low in medium treated FLS , but were rapidly *increased* by interleukin-1 and , although phospho-MKK6 levels only modestly increased . Positive_regulation PHOSPHO2 TNF 14695331 1195081 [Phospho-MKK3] levels were low in medium treated FLS , but were rapidly *increased* by interleukin-1 and , although phospho-MKK6 levels only modestly increased . Positive_regulation PI3 ANGPT1 10625301 658522 *induced* phosphorylation of Tie2 and the p85 subunit of phosphatidylinositol 3'-kinase ( PI 3'-kinase ) and increased [PI 3'-kinase] activity in a dose dependent manner . Positive_regulation PI3 ANGPT1 12514118 1063778 *induced* [PI3-kinase] activation prevents neuronal apoptosis . Positive_regulation PI3 ANGPT1 16061664 1439076 *activated* mitogen activated protein kinase (MAPK) and [phosphoinositide 3-kinase (PI3K)] in IBE cells and HUVECs . Positive_regulation PI3 CCND1 17700539 1848735 Transcriptional activation of c-myc and promoters by nuclear IRS-1 does not occur with a mutant , inactive IRS-1 protein ( deletion of the phosphotyrosine binding domain , PTB ) and does not *require* [PI3-kinase] activity . Positive_regulation PI3 CTGF 12218048 1012170 The inhibition of *induced* p42/44 MAPK or [phosphatidylinositol 3-kinase (PI3K)/protein] kinase B pathway activities abrogated the induction of fibronectin expression . Positive_regulation PI3 CTGF 16408113 1513486 *enhanced* the mRNA expression and protein release of fractalkine , MCP-1 , and RANTES , the expression of phospho ( P ) -p42/44 mitogen activated protein kinase (MAPK) , [P-phosphoinositide 3-kinase (PI3-K)] , P-Akt , and activity of nuclear factor-kappaB (NF-kappaB) in mesangial cells . Positive_regulation PI3 EDN2 10198327 605191 ( 10 ( -7 ) M ) *induced* a sustained increase in [PI 3-kinase] activity at both 30 s and 4 min of stimulation ( 151.5 +/- 8.5 % at 30 s and 175.8 +/- 8.7 % at 4 min , P < 0.005 ) . Positive_regulation PI3 EDN2 10198327 605194 Preincubation of smooth muscle cells with the tyrosine kinase inhibitor genistein ( 3 microM ) resulted in a significant inhibition of both C2 ceramide induced and induced [PI 3-kinase] *activation* and contraction . Positive_regulation PI3 EDN2 9843784 553611 Both ceramide- and *induced* [PI 3-kinase] activation was inhibited by C3 exoenzyme pretreatment . Positive_regulation PI3 EPHB2 11306698 804285 These results demonstrated that t-BHQ activated [PI3-kinase] and Akt , which was responsible for ARE mediated rGSTA2 induction , and that might negatively *regulate* rGSTA2 expression , whereas activation of p38 MAP kinase or of JNK by t-BHQ was not associated with the enzyme induction . Positive_regulation PI3 EPHB2 12138095 991547 Cell survival relied on two pertussis toxin-sensitive events , activation of and *activation* of [phosphatidylinositol 3-kinase (PI3K)/Akt] by S1P . Positive_regulation PI3 EPHB2 18340449 1932035 Using chondrosarcoma cells stimulated with IL-1beta , the effects of GLN on the mRNA and protein levels of MMP-3 , the *activation* of JNK , , p38 , NF-kappaB , and AP-1 , the nuclear translocation of NF-kappaB/Rel family members , and [PI3-kinase/Akt] activation were studied . Positive_regulation PI3 FAS 20153221 2214762 stimulation of CD95 on these cells *activated* [phosphoinositide 3-kinase (PI3K)] and metalloproteinase-9 ( MMP-9 ) via recruitment and activation of Syk kinase , ultimately leading to increased migration . Positive_regulation PI3 FAS 9446703 483668 Here , we demonstrate that ligation *induces* a rapid and transient tyrosine phosphorylation and activation of [phosphoinositide-3-kinase (PI-3-K)] in Jurkat T lymphocytes or CD95-sensitive glioma cells . Positive_regulation PI3 FAS 9446703 483670 Experiments using p56lck-deficient or p56lck reconstituted Jurkat clones and the tyrosine kinase inhibitor herbimycin A revealed that tyrosine phosphorylation and *activation* of [PI-3-K] by depends on expression of Src-like tyrosine kinases , in particular p56lck . Positive_regulation PI3 FAS 9468284 485773 We demonstrate a rapid and transient *activation* of [phosphoinositide-3-kinase (PI-3-K)] by receptor triggering or cellular treatment with synthetic C6-ceramide . Positive_regulation PI3 FAS 9468284 485775 Treatment with the caspase inhibitor Ac-YVAD-cmk or cellular transfection with transdominant inhibitory N17Ras prevented PI-3-K stimulation by Fas , suggesting that *activates* [PI-3-K] via caspases and Ras . Positive_regulation PI3 FUT4 23887626 2821555 Moreover , *induced* activation of [phosphatidylinositol 3-kinase (PI3K)/Akt] , and inactivation of GSK3ß and nuclear translocation of NF-?B , resulting in increased Snail and MMP-9 expression and greater cell motility . Positive_regulation PI3 GPR115 10187765 602634 Furthermore , we show that the p85 regulatory subunit is required for *activation* of [PI 3-kinase] activity by this . Positive_regulation PI3 GPR115 14980723 1214023 It has been proposed that [phosphoinositide 3-kinase (PI3K)] , one of the phosphatidylinositol kinases , can be *regulated* by as well as nerve growth factor associated receptors . Positive_regulation PI3 GPR115 24014027 2856634 The non-catalytic subunits are assumed to be redundant adaptors for Gß? enabling *mediated* regulation of [PI3K?] . Positive_regulation PI3 GPR115 9704065 479339 mediated *activation* of [PI 3-kinase] in neutrophils . Positive_regulation PI3 GPR132 10187765 602623 Furthermore , we show that the p85 regulatory subunit is required for *activation* of [PI 3-kinase] activity by this . Positive_regulation PI3 GPR132 14980723 1214012 It has been proposed that [phosphoinositide 3-kinase (PI3K)] , one of the phosphatidylinositol kinases , can be *regulated* by as well as nerve growth factor associated receptors . Positive_regulation PI3 GPR132 24014027 2856623 The non-catalytic subunits are assumed to be redundant adaptors for Gß? enabling *mediated* regulation of [PI3K?] . Positive_regulation PI3 GPR132 9704065 479328 *mediated* activation of [PI 3-kinase] in neutrophils . Positive_regulation PI3 GPR87 10187765 602703 Furthermore , we show that the p85 regulatory subunit is required for *activation* of [PI 3-kinase] activity by this . Positive_regulation PI3 GPR87 14980723 1214092 It has been proposed that [phosphoinositide 3-kinase (PI3K)] , one of the phosphatidylinositol kinases , can be *regulated* by as well as nerve growth factor associated receptors . Positive_regulation PI3 GPR87 24014027 2856703 The non-catalytic subunits are assumed to be redundant adaptors for Gß? enabling *mediated* regulation of [PI3K?] . Positive_regulation PI3 GPR87 9704065 479408 mediated *activation* of [PI 3-kinase] in neutrophils . Positive_regulation PI3 IL1B 17390080 1716152 We have previously demonstrated that *induced* HBD-2 mRNA expression in A549 cells through activation of nuclear factor-kappaB (NF-kappaB) transcriptional factor as well as p38 mitogen activated protein kinase (MAPK) , c-Jun N-terminal kinase (JNK) , or [phosphatidylinositol-3-kinase (PI3K)] . Positive_regulation PI3 IL1B 19136710 2060848 Brief stimulation of CECs with *activated* [PI 3-kinase] and p38 in a biphasic fashion . Positive_regulation PI3 IL1B 8858138 388414 These experiments suggest that can *activate* [PI 3-kinase] in renal mesangial cells and that the enzyme plays a role in IL-1 beta induced PGE2 and NO formation in the renal mesangial cell . Positive_regulation PI3 LAMB3 10926936 737186 Ligation of by integrin alpha(6)beta(4) *activates* [phosphoinositide 3-OH-kinase (PI3K)] signaling . Positive_regulation PI3 LAMB3 18283320 1878362 Recently , the [phosphatidylinositol 3-kinase (PI3K)] activation *induced* by during carcinogenesis or tumour invasion has been highlighted in skin squamous cell carcinoma . Positive_regulation PI3 MAP2K6 12137763 969039 Both and p38 inhibitors *stimulated* [PI-3K] . Positive_regulation PI3 MAP2K6 15934945 1414696 U0126 , a 1/2 ( MEK1/2 ) inhibitor , and LY294002 , a [phosphatidylinositol 3-kinase (PI3K)] *inhibitor* , both inhibited FGF2 induced BrdU incorporation , suggesting that the extracellular signal regulated kinase1/2 ( ERK1/2 ) and PI3K pathways are required for FGF2 induced NP cell proliferation . Positive_regulation PI3 MAP2K6 9858556 582038 Activated *stimulates* expression of AP-1 components independently of phosphatidylinositol 3-kinase ( [PI3-kinase] ) but requires a PI3-kinase signal To stimulate DNA synthesis . Positive_regulation PI3 NEDD9 9886492 584745 In contrast , tyrosine phosphorylation of p115 or

was undetectable by immunoblot with IGF-I stimulation , and [PI 3-kinase] activity was *mediated* via IRS-1 phosphorylated with IGF-I stimulation , little of which was associated with SHP-2 . Positive_regulation PI3 PECAM1 15632208 1387986 Sphingosine kinase-1 enhances endothelial cell survival through a dependent *activation* of [PI-3K/Akt] and regulation of Bcl-2 family members . Positive_regulation PI3 PECAM1 24030383 2857123 Activation of signaling *results* in its tyrosine phosphorylation , the recruitment and activation of tyrosine phosphatase SHP-2 , the subsequent binding of [phosphoinositol 3-kinase (PI3K)] , and diminished PI3K signaling . Positive_regulation PI3 PODXL 17616675 1769281 expression also *led* to an increase in mitogen activated protein kinase (MAPK) and [phosphatidylinositol 3-kinase (PI3K)] activity . Positive_regulation PI3 PTGER2 23575689 2768176 Meanwhile , cAMP mediated suppression of T-cell receptor signalling is overcome by simultaneous *activation* of [PI3-kinase] through and/or CD28 . Positive_regulation PI3 S1PR3 12385647 1034880 We previously demonstrated that sphingosine 1-phosphate (S1P) induced PLD activation via the G-protein coupled receptor was *involved* in S1P induced stimulation of [PI 3-kinase] and Akt . Positive_regulation PI3 STK39 14517417 581703 Stimulation of primary bovine capillary endothelial ( BCE ) cells with FGF-2 , VEGF-A ( 165 ) , or a combination of the two induced [PI3-kinase] activity in vitro and subsequent *activation* of the Akt . Positive_regulation PI3 STK39 15657037 1381689 Taken together , these data suggest that 1 ) TGFbeta receptors can indirectly associate with p85 , 2 ) both receptors are required for ligand induced PI3 kinase activation , and 3 ) the activated TbetaRI can potently *induce* [PI3] kinase activity . Positive_regulation PI3 TLR7 18287072 1872562 However , when coupled with Sema6D , a ligand for Plexin-A1 , limited *resulted* in PDC-TREM mediated DAP12 dependent phosphorylation of [phosphoinositide 3-kinase (PI3K)] and extracellular regulated kinase (Erk) 1/2 at 6-9 h , and IFN-alpha was produced . Positive_regulation PI3 TLR7 21665146 2442683 Receptor tyrosine kinases and unexpectedly *activate* myeloid cell [PI3k?] , a single convergent point promoting tumor inflammation and progression . Positive_regulation PI3 TLR7 23979601 2850725 Both [phosphatidylinositol 3-kinase (PI3K)-Akt] and p38 mitogen activated protein kinase (MAPK) signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Positive_regulation PI3 TNF 10187765 602512 also *stimulated* increased [PI 3-kinase] activity , however TNFalpha stimulated NF-kappaB activation was not affected by the PI 3-kinase inhibitors or the p85 dominant negative mutant . Positive_regulation PI3 TNF 10419100 631716 The mechanisms by which and ceramides *increase* [PI 3-kinase] activity were investigated further by using rat2 fibroblasts . Positive_regulation PI3 TNF 10640750 660653 Consistent with its involvement in TNF signaling , [PI 3-kinase] activities in HepG2 and U937 cells can be *stimulated* by in a rapid but transient manner through a mechanism that may involve its association with the insulin receptor substrate-1 . Positive_regulation PI3 TNF 10753884 682350 Interestingly , [PI 3-kinase] activity also was *enhanced* by , and NF-kappaB pathway was involved in mediating its effect . Positive_regulation PI3 TNF 10836611 698053 SB202190 or SB203580 , two specific p38 MAP kinase inhibitors almost completely blocked the *induction* of [SKALP] expression by and serum . Positive_regulation PI3 TNF 11247802 793350 *induced* marked activation of [PI3-kinase] and Akt/PKB , and the activation of PI3-kinase and Akt/PKB was rapid ( maximal at 10 and 15 min , respectively ) and concentration dependent . Positive_regulation PI3 TNF 11266376 796739 can *activate* [PI 3-kinase] directly in addition to inducing COX-2 . Positive_regulation PI3 TNF 11423913 831044 These results suggest that *induced* MAP kinase and [PI3-kinase/Akt] signaling play important roles in protecting BAE cells from TNF cytotoxicity . Positive_regulation PI3 TNF 12218155 986514 In contrast , both fMLP and alone *caused* a 3-fold increase in [PI3-kinase] activity in p110gamma PI3-kinase immunoprecipitates . Positive_regulation PI3 TNF 12230886 988344 Induction of the SKALP promoter by *resulted* in increased expression levels of the secreted [SKALP-EGFP] fusion protein as assessed by direct readout of fluorescence and fluorescence polarization in 96-well cell culture plates . Positive_regulation PI3 TNF 15115707 1279370 Coimmunoprecipitation studies established that [PI 3-kinase] , delta-PKC , and TNFR-1 formed a signal complex in *response* to . Positive_regulation PI3 TNF 15703956 1497476 *Activation* of p38 mitogen activated protein (MAP) kinase and [phosphatidylinositol 3-kinase (PI3K)] by was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation PI3 TNF 15953363 1421745 It inhibits *induced* [PI3-kinase] , Akt and NF-kappaB activation in these cells . Positive_regulation PI3 TNF 16794257 1631657 Quercetin also inhibited *induced* [PI 3-kinase] activity , Akt phosphorylation , intracellular H ( 2 ) O ( 2 ) production , NF-kappaB transactivation , IL-8 promoter activity , and steady-state mRNA levels , consistent with the notion that quercetin inhibits chemokine expression by attenuating NF-kappaB transactivation via a PI 3-kinase/Akt dependent pathway . Positive_regulation PI3 TNF 17607712 1798197 Although *induced* the activation of p38 MAPK , JNK , ERK and [PI-3K] signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation PI3 TNF 18632801 1972585 also *caused* [PI3-kinase/Akt] activation , which was further increased by PDTC and prevented by the PI3-kinase inhibitor , LY294002 . Positive_regulation PI3 TNF 8557661 347515 In murine 3T3-L1 adipocytes , IRS-1 and [PI 3-kinase] phosphorylation and the association of these proteins are *promoted* by murine , which interacts with the type 1 and type 2 TNF receptors . Positive_regulation PI4KA SNCAIP 8864845 388988 The activity of [PI 4-kinase] in the platelet lysate was *increased* by sphingosine but not by . Positive_regulation PI4KB CABP4 11020214 737815 This was a novel finding and suggests that a activates and *regulates* [PtdIns 4-kinasebeta] . Positive_regulation PI4KB SNCAIP 8864845 388989 The activity of [PI 4-kinase] in the platelet lysate was *increased* by sphingosine but not by . Positive_regulation PIAS2 TNF 20624960 2297179 The interaction between Mule and [Miz1] was *promoted* by independently of the pox virus and zinc finger domain of Miz1 . Positive_regulation PIEZO1 F2R 19686683 2126367 The phosphorylation of Mib by *results* in [Mib] degradation , repression of Notch signaling , and stimulation of neuronal differentiation . Positive_regulation PIGA PIGR 9430737 474443 The endometrium can likewise perform *mediated* external translocation of [pIgA] that in this tissue appears to be mainly derived from serum , partly under hormonal regulation . Positive_regulation PIGR CD79A 9649586 515375 The secretory antibody response to infections of mucosal surfaces *requires* transport of IgA from the basal to apical surface of mucosal epithelial cells by a specific transport protein , the [polymeric immunoglobulin receptor (pIgR)] . Positive_regulation PIGR ERVK-6 15270729 1276282 Cleavage of [pIgR] on the cell surface was partially *inhibited* by the inhibitor , leupeptin . Positive_regulation PIGR IFNG 10233739 611575 and IL-4 *induced* similar maximal expression of [pIgR] , but IFN-gamma enhanced sIgA release more than IL-4 . Positive_regulation PIGR IFNG 12242032 989747 We report here that strongly *increased* [pIgR] mRNA levels through a direct effect on mammary epithelial cells . Positive_regulation PIGR IFNG 8455639 215445 We studied the mechanism by which *induces* [pIgR] expression in HT-29.74 cells , a subclone of the HT-29 cell line selected for high concns of pIgR . Positive_regulation PIGR IFNG 8455639 215446 This assay was used to determine if *induction* of [pIgR] by is mediated by accumulation of pIgR mRNA . Positive_regulation PIGR IFNG 8455639 215447 These results suggest that *induction* of [pIgR] expression by involves an increase in steady-state concns of pIgR mRNA via a protein synthesis dependent mechanism . Positive_regulation PIGR IFNG 9182878 436341 It is now shown that IRF-1 is not detected in nuclear extracts from HT-29 cells stimulated with IFN-gamma in the presence of cycloheximide , suggesting that de novo synthesis of IRF-1 is required for *induction* of [pIgR] transcription by . Positive_regulation PIGR IL10 9415030 471883 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL11 9415030 471884 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL13 9415030 471885 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL15 9415030 471886 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL16 9415030 471887 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL18 9415030 471888 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL19 9415030 471889 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL1A 20173656 2327142 Tumor necrosis factor (TNF)-a and *stimulate* the production of [polymeric immunoglobulin receptor] , the protein required to transport immunoglobulin A (IgA) to mucosal surfaces . Positive_regulation PIGR IL1B 18363466 1887870 Tumor necrosis factor-alpha (TNF-alpha) and *stimulate* the production of [polymeric immunoglobulin receptor (pIgR)] , the protein required to transport immunoglobulin A (IgA) to mucosal surfaces . Positive_regulation PIGR IL2 9415030 471890 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL20 9415030 471891 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL21 9415030 471892 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL22 9415030 471875 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL24 9415030 471873 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL25 9415030 471874 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL26 9415030 471879 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL27 9415030 471880 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL3 9415030 471893 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL31 9415030 471881 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL32 9415030 471878 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL33 9415030 471877 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL34 9415030 471882 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL37 9415030 471876 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL4 10233739 611576 IFN-gamma and *induced* similar maximal expression of [pIgR] , but IFN-gamma enhanced sIgA release more than IL-4 . Positive_regulation PIGR IL4 9415030 471894 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL5 9415030 471895 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL6 9415030 471896 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL7 9415030 471897 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL8 9415030 471898 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IL9 9415030 471899 The [polymeric immunoglobulin receptor] ( secretory component ) in a human intestinal epithelial cell line is *up-regulated* by . Positive_regulation PIGR IRF1 9182878 436342 It is now shown that IRF-1 is not detected in nuclear extracts from HT-29 cells stimulated with IFN-gamma in the presence of cycloheximide , suggesting that de novo synthesis of is *required* for induction of [pIgR] transcription by IFN-gamma . Positive_regulation PIGR JAK1 23160152 2860356 Because IL-4 stimulates IgA and is reduced during PN , we hypothesized that the suppressed [pIgR] is a *result* of decreased and STAT-6 phosphorylation . Positive_regulation PIGR MAPK1 17971154 1866677 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Positive_regulation PIGR MAPK1 20450283 2257158 Induction of [pIgR] expression in HT-29 cells *required* NF-kappaB signaling but not signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation PIGR MAPK10 17971154 1866678 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Positive_regulation PIGR MAPK10 20450283 2257159 Induction of [pIgR] expression in HT-29 cells *required* NF-kappaB signaling but not signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation PIGR MAPK11 17971154 1866679 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Positive_regulation PIGR MAPK11 20450283 2257160 Induction of [pIgR] expression in HT-29 cells *required* NF-kappaB signaling but not signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation PIGR MAPK12 17971154 1866680 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Positive_regulation PIGR MAPK12 20450283 2257161 Induction of [pIgR] expression in HT-29 cells *required* NF-kappaB signaling but not signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation PIGR MAPK13 17971154 1866681 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Positive_regulation PIGR MAPK13 20450283 2257162 Induction of [pIgR] expression in HT-29 cells *required* NF-kappaB signaling but not signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation PIGR MAPK14 17971154 1866682 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Positive_regulation PIGR MAPK14 20450283 2257163 Induction of [pIgR] expression in HT-29 cells *required* NF-kappaB signaling but not signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation PIGR MAPK15 17971154 1866676 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Positive_regulation PIGR MAPK15 20450283 2257157 Induction of [pIgR] expression in HT-29 cells *required* NF-kappaB signaling but not signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation PIGR MAPK3 17971154 1866683 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Positive_regulation PIGR MAPK3 20450283 2257164 Induction of [pIgR] expression in HT-29 cells *required* NF-kappaB signaling but not signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation PIGR MAPK4 17971154 1866684 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Positive_regulation PIGR MAPK4 20450283 2257165 Induction of [pIgR] expression in HT-29 cells *required* NF-kappaB signaling but not signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation PIGR MAPK6 17971154 1866685 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Positive_regulation PIGR MAPK6 20450283 2257166 Induction of [pIgR] expression in HT-29 cells *required* NF-kappaB signaling but not signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation PIGR MAPK7 17971154 1866686 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Positive_regulation PIGR MAPK7 20450283 2257167 Induction of [pIgR] expression in HT-29 cells *required* NF-kappaB signaling but not signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation PIGR MAPK8 17971154 1866687 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Positive_regulation PIGR MAPK8 20450283 2257168 Induction of [pIgR] expression in HT-29 cells *required* NF-kappaB signaling but not signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation PIGR MAPK9 17971154 1866688 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Positive_regulation PIGR MAPK9 20450283 2257169 Induction of [pIgR] expression in HT-29 cells *required* NF-kappaB signaling but not signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation PIGR NFKB1 14678201 1189435 In studies using human intestinal epithelial cells ( HT29 ) , multiple inhibitors of the transcription factor , including a dominant negative IkappaBalpha-serine mutant , *inhibited* both IL-4- and IFN dependent increases in [pIgR] expression . Positive_regulation PIGR NFKB1 20450283 2257170 Induction of [pIgR] expression in HT-29 cells *required* signaling but not MAPK signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation PIGR PIGA 11169207 783364 These data suggest that the species difference in *induced* [pIgR-transcytosis] does not stem from the defective production of second messengers , but from a different sensitivity of pIgR to intracellular calcium . Positive_regulation PIGR PIK3C3 17971154 1866689 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both mitogen activated protein kinase and in HT-29 cell line . Positive_regulation PIGR PIK3R4 17971154 1866690 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both mitogen activated protein kinase and in HT-29 cell line . Positive_regulation PIGR RELA 14678201 1189436 In studies using human intestinal epithelial cells ( HT29 ) , multiple inhibitors of the transcription factor , including a dominant negative IkappaBalpha-serine mutant , *inhibited* both IL-4- and IFN dependent increases in [pIgR] expression . Positive_regulation PIGR RELA 20450283 2257171 Induction of [pIgR] expression in HT-29 cells *required* signaling but not MAPK signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation PIGR STAT6 11034397 740719 Thus , activation *mediates* a delayed transcriptional enhancement of [pIgR] by induction of a de novo synthesized protein that cooperates with STAT6 itself bound to its cognate DNA element in intron 1 . Positive_regulation PIGR STAT6 23160152 2860355 Because IL-4 stimulates IgA and is reduced during PN , we hypothesized that the suppressed [pIgR] is a *result* of decreased JAK-1 and phosphorylation . Positive_regulation PIGR TCF12 12794133 1098048 Extensive overlap in the tissue distribution of hepatocyte NF-1 and pIgR suggests that this *contributes* to tissue-specific [pIgR] expression . Positive_regulation PIGR TCF12 9973374 596023 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Positive_regulation PIGR TCF15 12794133 1098049 Extensive overlap in the tissue distribution of hepatocyte NF-1 and pIgR suggests that this *contributes* to tissue-specific [pIgR] expression . Positive_regulation PIGR TCF15 9973374 596024 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Positive_regulation PIGR TCF19 12794133 1098050 Extensive overlap in the tissue distribution of hepatocyte NF-1 and pIgR suggests that this *contributes* to tissue-specific [pIgR] expression . Positive_regulation PIGR TCF19 9973374 596025 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Positive_regulation PIGR TCF20 12794133 1098051 Extensive overlap in the tissue distribution of hepatocyte NF-1 and pIgR suggests that this *contributes* to tissue-specific [pIgR] expression . Positive_regulation PIGR TCF20 9973374 596026 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Positive_regulation PIGR TCF21 12794133 1098052 Extensive overlap in the tissue distribution of hepatocyte NF-1 and pIgR suggests that this *contributes* to tissue-specific [pIgR] expression . Positive_regulation PIGR TCF21 9973374 596027 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Positive_regulation PIGR TCF23 12794133 1098056 Extensive overlap in the tissue distribution of hepatocyte NF-1 and pIgR suggests that this *contributes* to tissue-specific [pIgR] expression . Positive_regulation PIGR TCF23 9973374 596031 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Positive_regulation PIGR TCF24 12794133 1098058 Extensive overlap in the tissue distribution of hepatocyte NF-1 and pIgR suggests that this *contributes* to tissue-specific [pIgR] expression . Positive_regulation PIGR TCF24 9973374 596033 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Positive_regulation PIGR TCF25 12794133 1098057 Extensive overlap in the tissue distribution of hepatocyte NF-1 and pIgR suggests that this *contributes* to tissue-specific [pIgR] expression . Positive_regulation PIGR TCF25 9973374 596032 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Positive_regulation PIGR TCF3 12794133 1098053 Extensive overlap in the tissue distribution of hepatocyte NF-1 and pIgR suggests that this *contributes* to tissue-specific [pIgR] expression . Positive_regulation PIGR TCF3 9973374 596028 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Positive_regulation PIGR TCF4 12794133 1098054 Extensive overlap in the tissue distribution of hepatocyte NF-1 and pIgR suggests that this *contributes* to tissue-specific [pIgR] expression . Positive_regulation PIGR TCF4 9973374 596029 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Positive_regulation PIGR TCF7 12794133 1098055 Extensive overlap in the tissue distribution of hepatocyte NF-1 and pIgR suggests that this *contributes* to tissue-specific [pIgR] expression . Positive_regulation PIGR TCF7 9973374 596030 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Positive_regulation PIGR TNF 10803841 690583 Stimulation by significantly *activated* the [pIgR] gene promoter , as a 775-bp upstream region of the pIgR gene increased luciferase gene expression in cells treated with TNF-alpha . Positive_regulation PIGR TNF 10803841 690584 These data indicated that [pIgR] gene expression *induced* by is transcriptionally regulated via activation of NF-kappaB . Positive_regulation PIGR TNF 11714807 881444 The proinflammatory cytokine is a key mediator of host responses to infections , and it can *stimulate* protein synthesis dependent transcriptional up-regulation of [pIgR/SC] in the HT-29 intestinal adenocarcinoma cell line . Positive_regulation PIGR TNF 11714807 881445 Thus , DNA elements located > 4 kb apart were found to cooperate in *induced* [pIgR/SC] up-regulation . Positive_regulation PIGR TNF 15265917 1275623 activates a proinflammatory gene repertoire in mucosal epithelial cells and also *enhances* [pIgR] expression . Positive_regulation PIGR TNF 15265917 1275624 In this study we show that *induced* up-regulation of the human [pIgR] critically depends on an NF-kappa B site and flanking sequences within a 204-bp region of the first intron in the pIgR gene , a region largely overlapping with a recently characterized IL-4-responsive enhancer . Positive_regulation PIGR TNF 18363466 1887869 and interleukin-1 beta (IL-1beta) *stimulate* the production of [polymeric immunoglobulin receptor (pIgR)] , the protein required to transport immunoglobulin A (IgA) to mucosal surfaces . Positive_regulation PIGR TNF 20173656 2327141 and interleukin (IL)-1ß *stimulate* the production of [polymeric immunoglobulin receptor] , the protein required to transport immunoglobulin A (IgA) to mucosal surfaces . Positive_regulation PIH TNF 19588763 2105272 Compared with those of HC group , plasma levels of LPS and in LPS group significantly *increased* at 2nd [PIH] ( 18,320.50 +/- 2782.50 EU/mL and 988 +/- 130 ng/L , respectively ) , then decreased gradually to 1.80 +/- 0.80 EU/mL and 150 +/- 44 ng/L at 72nd PIH , which was close to those of HC group . Positive_regulation PIK3C2B CAPN8 11931646 961563 The data presented in this report show that in renal cells there is a spatial separation of the inositol lipid signalling system between BLM and BBM , and that HGF causes activation of PLC and PI3K primarily in BLM , which leads to mediated *activation* of [PI3K-C2 beta] in BBM with a concomitant increase in PtdIns3P . Positive_regulation PIK3C2B CAPN8 12573450 1057511 The presence of PI3K inhibitor LY 294002 completely abolished the *mediated* increase in the activity of [PI3K-C2beta] but did not prevent the gel shift . Positive_regulation PIK3C2B CAPN8 12573450 1057525 These results demonstrate the mediated *activation* of the nuclear [PI3K-C2beta] during G ( 2 ) /M phase of the cell cycle in HL-60 cells . Positive_regulation PIK3C3 EPHB2 11445578 850497 *regulates* the hepatocyte growth factor mediated interaction of Gab1 and the [phosphatidylinositol 3-kinase] . Positive_regulation PIK3C3 EPHB2 16844778 1592173 Activated Src phosphorylates Cbl , which recruits the p85 subunit of phosphatidylinositol 3-kinase , resulting in [phosphatidylinositol 3-kinase] activation and eventually the *activation* of Akt and . Positive_regulation PIK3C3 EPHB2 19479862 2097677 The MAPKs p38 , JNK , and were necessary for IL-6 production , but [phosphatidylinositol 3-kinase] ( PI 3-kinase ) was *required* for selective CCL5 induction . Positive_regulation PIK3C3 FAS 11729103 897048 Instead , the early inhibition of p38 MAPK concurred with a *induced* activation of [phosphatidylinositol 3-kinase] , inhibition of which reduced apoptosis . Positive_regulation PIK3C3 FAS 11729103 897063 We conclude that p38 MAPK activity represents a survival signal that is inactivated transiently during both spontaneous and Fas induced apoptosis , whereas *induced* [phosphatidylinositol 3-kinase] activity is a proapoptotic signal in isolated human neutrophils . Positive_regulation PIK3C3 FAS 19204002 2049788 The up-regulation of both SREBP and by NS4B protein *required* [phosphatidylinositol 3-kinase] activity . Positive_regulation PIK3C3 S1PR3 15334188 1291024 Finally , S1P also protects endothelial cells from apoptosis through *activation* of [phosphatidylinositol 3-kinase/Akt/eNOS] via S1P(1) and receptors . Positive_regulation PIK3C3 SPHK1 16622018 1551522 Macrophage 's proinflammatory response to a mycobacterial infection is dependent on mediated *activation* of phosphatidylinositol phospholipase C , protein kinase C , ERK1/2 , and [phosphatidylinositol 3-kinase] . Positive_regulation PIK3C3 TNF 11266376 796727 There has been recent speculation on the *activation* of [phosphatidylinositol 3-kinase] ( PI 3-kinase ) by and its role in the regulation of genes controlled by NF-kappaB . Positive_regulation PIK3C3 TNF 11356844 834433 *Activation* of [phosphatidylinositol (PI) 3-kinase/Akt] signaling by activates IKK and NF-kappaB . Positive_regulation PIK3C3 TNF 14592823 1209472 Furthermore , *mediated* activation of [phosphatidylinositol 3-kinase] ( PI 3-kinase ) represents an additional essential signaling component in this process as demonstrated by studies with its inhibitor wortmannin as well as by analysis of the phosphorylation of AKT kinase . Positive_regulation PIK3C3 TNF 15722197 1374646 The *activation* of NF-kappaB and [phosphatidylinositol-3 (PI3) kinase] by and TRAIL overrides the pro-apoptotic effects of these ligands in carcinoma cells and hinders their therapeutic application . Positive_regulation PIK3C3 TNF 23538493 2788589 In addition , *induced* a downregulation of claudin-1 , claudin-2 , claudin-4 , and occludin as well as activation of [phosphatidylinositol 3-kinase] signaling in T-84 but not Caco-2 cells , which was reversed by adalimumab . Positive_regulation PIK3C3 TNFSF10 15722197 1374647 The *activation* of NF-kappaB and [phosphatidylinositol-3 (PI3) kinase] by TNF-alpha and overrides the pro-apoptotic effects of these ligands in carcinoma cells and hinders their therapeutic application . Positive_regulation PIK3CA CCND1 16522728 1531465 We conclude that incretin induced beta-cell replication is dependent on cAMP/PKA , p42 MAPK and [PI3K] activities , which may *involve* transcriptional induction of . Positive_regulation PIK3CA CCND1 22579115 2609560 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated and Cyclin B1 proteins as well as *activation* of [PI3K/Akt] and Raf/MEK/ERK , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation PIK3CA CD14 22561121 2608693 Zaprinast was found to activate ERK1/2 , p38 MAPK , JNK , NF?B , and [PI3K/Akt] , and subsequently , *induce* the mRNA expressions of IL-1a , IL-1ß , TNF-a , CCL2 , CCL4 , CXCL1 , CXCL2 , and . Positive_regulation PIK3CA CHI3L1 19915670 2166566 NF1-loss was associated with lower overall MAPK and [PI3K] *activation* and relative overexpression of the mesenchymal marker . Positive_regulation PIK3CA CTGF 16408113 1513533 P-PI3-K blockade downregulated the *stimulated* expression of [P-PI3-K] , P-Akt , and NF-kappaB but not P-p42/44 MAPK , and partially decreased the release of the above chemokines . Positive_regulation PIK3CA CTGF 16408113 1513542 LXA ( 4 ) dose-dependently inhibited the *stimulated* mRNA expression and protein release of the above chemokines , and the expression of P-p42/44MAPK , [P-PI3-K] , P-Akt , and NF-kappaB . Positive_regulation PIK3CA CTGF 23681229 2785478 Our studies are the first to demonstrate that reduced as an unfavorable prognosis factor *mediates* the activation of miR-18b , an oncomir directly suppresses CTGF expression , by [PI3K/AKT/C-Jun] and C-Myc and promotes cell growth of NPC . Positive_regulation PIK3CA EPHB2 11100733 755935 The G betagamma-responsive activation induced by H2O2 is independent of ligands binding to Gi-coupled receptors , but *requires* [phosphatidylinositol-3-kinase] and Src activation . Positive_regulation PIK3CA EPHB2 11444915 834159 Analogous to ISO , AII treatment increased and PI3-K activity , and [PI3-K] was *required* for protein synthesis . Positive_regulation PIK3CA EPHB2 11896055 944398 negatively *regulates* the epidermal growth factor mediated interaction of Gab1 and the [phosphatidylinositol 3-kinase] . Positive_regulation PIK3CA EPHB2 11896055 944424 HGF stimulated ERK activation increases the Gab1/PI3K association , whereas EGF stimulated activation *results* in a decrease in the tyrosine phosphorylation of Gab1 and a decreased association with the [PI3K] . Positive_regulation PIK3CA EPHB2 12681450 1077459 This report shows that the [PI3K] inhibitors LY294002 and wortmannin block *activation* of MEK and by IL-2 in primary human T cells . Positive_regulation PIK3CA EPHB2 16118117 1449221 The impedance by leptin of the LPS inhibitory effect on mucin synthesis was blocked by wortmannin , an *inhibitor* of [PI3K] , as well as by inhibitor , PD98059 . Positive_regulation PIK3CA EPHB2 16754300 1571455 The impedance by PAF antagonist of the LPS induced reduction in mucin synthesis was countered by wortmannin , an *inhibitor* of [PI3K] , as well as by inhibitor , PD98059 . Positive_regulation PIK3CA EPHB2 16782756 1625039 Taken together , these data demonstrate that mtALDH overexpression attenuates hyperoxia induced cell death in lung epithelial cells through reduction of ROS , *activation* of , and [PI3K-Akt] cell survival signaling pathways . Positive_regulation PIK3CA EPHB2 16983494 1617419 The inhibition by PAF antagonist of the LPS induced reduction in mucin synthesis was countered by wortmannin , an *inhibitor* of [PI3K] , as well as by inhibitor , PD98059 . Positive_regulation PIK3CA EPHB2 17540722 1778468 inhibitor PD98059 *inhibited* the [PI3K] activity , Akt phosphorylation , and lipid accumulation triggered by HG . Positive_regulation PIK3CA EPHB2 20433817 2268173 Taken together , these results suggest that gomesin could be a useful anticancer agent , which mechanism of cytotoxicity implicates calcium entry through L-type calcium channels , *activation* of , PKC and [PI3K] signaling as well as the generation of reactive oxygen species . Positive_regulation PIK3CA EPHB2 21129142 2401918 These findings highlight the importance of IAV induced and [PI3K] early *activation* as signalling mediators in V-ATPase stimulated endosomal acidification required for fusion . Positive_regulation PIK3CA EPHB2 22960230 2684084 Our data suggest that dual [PI3K/mTOR] inhibitors may represent a useful pharmacological tool in the therapy of advanced adrenocortical cancer and that simultaneous inhibition of both and PI3K - mTOR pathways may be *required* to obtain a higher antiproliferative effect in this type of tumor . Positive_regulation PIK3CA EPHB2 9892010 586570 We show that the activation of via SSTR1 is pertussis toxin sensitive and *requires* the small G protein Ras , [phosphatidylinositol 3-kinase] , the serine/threonine kinase Raf-1 , and the protein tyrosine phosphatase SHP-2 . Positive_regulation PIK3CA F2R 11065174 746981 Thus , the PAR-1 mediated contraction is considered to be dependent on intracellular and extracellular Ca2+ , the influx of the latter being induced through activation of L-type Ca2+ channels triggered by the enhanced Na+ permeability , and that PLC and [PI3K] , in addition to PKC and TK , are involved in the *mediated* dual responses . Positive_regulation PIK3CA FOXO1 20709952 2312826 However , whereas the [PI(3)K/Akt] regulation of Rag transcription is *mediated* by , we show in this study that the MEK/ERK pathway coordinates with the regulation of Rag by controlling the phosphorylation and turnover of E47 and its consequential binding to the Rag enhancer regions . Positive_regulation PIK3CA FUT4 20506505 2307963 These data suggested that not only *activates* MAPK and [PI3K/Akt] signals , but also promotes the crosstalk among these signaling pathways . Positive_regulation PIK3CA GPR115 10400698 628585 We have analyzed in Chinese hamster ovary cells the upstream mediators by which the , gastrin/CCKB , *activates* the extracellular regulated kinases ( ERKs ) and [p85/p110-phosphatidylinositol 3-kinase] ( PI 3-kinase ) pathways . Positive_regulation PIK3CA GPR132 10400698 628574 We have analyzed in Chinese hamster ovary cells the upstream mediators by which the , gastrin/CCKB , *activates* the extracellular regulated kinases ( ERKs ) and [p85/p110-phosphatidylinositol 3-kinase] ( PI 3-kinase ) pathways . Positive_regulation PIK3CA GPR87 10400698 628654 We have analyzed in Chinese hamster ovary cells the upstream mediators by which the , gastrin/CCKB , *activates* the extracellular regulated kinases ( ERKs ) and [p85/p110-phosphatidylinositol 3-kinase] ( PI 3-kinase ) pathways . Positive_regulation PIK3CA IGFBP1 9325295 456815 complex with hST-3 restores IGF-I *induced* proliferation and [PI 3-K] kinase activity in these cells . Positive_regulation PIK3CA IL1B 16567807 1562239 Western blot analysis combined with I ( GABA ) recording and confocal images of GABA ( A ) Rs in oocytes showed that *stimulates* the IL-1RI dependent [phosphatidylinositol 3-kinase] activation and the consequent facilitation of phospho-Akt mediated insertion of GABA ( A ) Rs into the cell surface . Positive_regulation PIK3CA IL1B 17299794 1718843 Src , PDGFR , and [PI3K/Akt] *mediated* the effects of because pretreatment with PP1 , AG1296 , and wortmannin also abrogated IL-1beta stimulated Src , PDGFR , and Akt phosphorylation , respectively . Positive_regulation PIK3CA IL1B 17390080 1716170 Addition of triptolide did not suppress activation of p38 MAPK , JNK , or [PI3K] in *response* to . Positive_regulation PIK3CA IL1B 17504920 1744646 In summary , results presented herein demonstrate that *stimulates* [PI3K/PKB-] , P70S6K- , and ERK1/2 dependent pathways in rat Sertoli cells . Positive_regulation PIK3CA INPP4B 24288008 2926682 We further demonstrate that *regulates* [PI3K/Akt] signaling and exerts a tumor suppressor effect , impacting the proliferative , invasive , and tumorigenic capacity of melanoma cells . Positive_regulation PIK3CA IRS4 20079766 2225643 We report also Ins induced [PI3-K] activation *mediated* by . Positive_regulation PIK3CA ITGAL 11359803 816334 mediated costimulation of CD8+ T cell proliferation *requires* [phosphatidylinositol 3-kinase] activity . Positive_regulation PIK3CA ITGB2 14960575 1227760 We have identified Vav , a guanine nucleotide exchange factor for Rac-1 , and PI3K/Akt , as regulators of the activation and inactivation phases of the activity of Rac-1 , respectively , in the context of LFA-1 signaling based on the following experimental evidence : ( i ) *induced* activation of Vav and [PI3K/Akt] with kinetics consistent with a regulatory role for these molecules on Rac-1 , ( ii ) overexpression of a constitutively active Vav mutant induces activation of Rac independently of LFA-1 stimulation whereas overexpression of a dominant negative Vav mutant blocks LFA-1 mediated Rac activation , ( iii ) pharmacological inhibition of PI3K/Akt prevented the fall in the activity of Rac-1 after its initial activation but had no effect on Vav activity , and ( iv ) overexpression of a dominant negative or a constitutively active Akt-1 induced or inhibited , respectively , Rac-1 activity . Positive_regulation PIK3CA LAMB3 18283320 1878365 The expression of laminin-332 in 126 resected oesophageal squamous cell carcinoma ( ESCC ) specimens was immunohistochemically examined to determine its associations with the clinicopathological characteristics , and the effect of on the invasiveness and the [PI3K] *activation* was assessed by in vitro experiments using ESCC cell lines ( ESCCs ) . Positive_regulation PIK3CA MAP2K6 12114408 964062 Our results suggest the combination of paclitaxel and inhibitor *leads* to down-regulation of the [PI3K-Akt] signaling in addition to the proapoptotic effects of paclitaxel and MEK inhibitor alone . Positive_regulation PIK3CA MAP2K6 12681450 1077466 This report shows that the [PI3K] inhibitors LY294002 and wortmannin block *activation* of and ERK by IL-2 in primary human T cells . Positive_regulation PIK3CA MAP2K6 15618457 1387795 The [PI3K] *inhibitors* wortmannin and LY-294002 and an Akt inhibitor , 1-L-6-hydroxymethyl-chiro-inositol 2- ( R ) -2-O-methyl-3-O-octadecylcarbonate , but not a inhibitor PD-98059 , blocked isoproterenol mediated eosinophil survival . Positive_regulation PIK3CA MAP2K6 21769916 2494847 In TGW cells , PD98059 , a inhibitor , but not SB203580 ( a p38 MAPK inhibitor ) and LY294002 ( a [PI3K] *inhibitor* ) inhibited GDNF induced GAP43 expression , suggesting the MEK/ERK pathway has a major role in GDNF induced GAP43 transcription . Positive_regulation PIK3CA MAP2K6 24442130 2918073 Inhibition of these pathways utilizing PF-04691502 , a [PI3K] and mTOR *inhibitor* , and PD-0325901 , a inhibitor , slowed the tumor growth of PDX models of bladder cancer . Positive_regulation PIK3CA MAP2K6 9595422 505967 The effect of ET-1 in suppressing apoptosis was unaffected by any of the following reagents : a phospholipase C inhibitor ( U73122 ) , a tyrosine kinase inhibitor ( ST638 ) , an inhibitor ( PD98059 ) , a [phosphatidylinositol-3 kinase] *inhibitors* ( wortmannin , LY294002 ) . Positive_regulation PIK3CA MMP7 21273532 2419763 Collectively , these findings indicate that ACh induced cell migration is mediated by *mediated* release of HBEGF , an ERBB ligand that activates ERBB1 and downstream ERK and [PI3K] signaling . Positive_regulation PIK3CA NGFR 22880054 2641726 Whereas Src kinases are often required for Syk activation , we show here that [PI3K/Akt] *activation* and autocrine IL-10 production by involves the Src family kinase Fyn . Positive_regulation PIK3CA PECAM1 24030383 2857124 Activation of signaling *results* in its tyrosine phosphorylation , the recruitment and activation of tyrosine phosphatase SHP-2 , the subsequent binding of phosphoinositol 3-kinase (PI3K) , and diminished [PI3K] signaling . Positive_regulation PIK3CA PLAT 17498240 1739846 Consistent with neurotrophic effects , *activated* Raf-K/ERK , PKC and [PI3-K/Akt] , 5-60 min after treatment . Positive_regulation PIK3CA PLAT 23562854 2778002 Glucose deprivation induced activation of [PI3K-Akt-GSK3ß] , p38 and AMPK , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation PIK3CA PLAU 10995743 752344 We demonstrate that *induces* [PI3-K] activation , which is abolished in VSMC expressing the dominant negative form of Tyk2 . Positive_regulation PIK3CA PLAU 10995743 752346 The regulatory subunit p85 of PI3-K co-immunoprecipitates with Tyk2 but not with Jak1 , Jak2 , or Jak3 , and stimulation *increases* the [PI3-K] activity in Tyk2 immunoprecipitates . Positive_regulation PIK3CA PLAU 10995743 752349 We provide evidence that the Tyk2 mediated [PI3-K] activation in *response* to is required for VSMC migration . Positive_regulation PIK3CA PLAU 12545160 1051060 Downregulation of *inhibits* migration and [PI3k/Akt] signaling in glioblastoma cells . Positive_regulation PIK3CA PODXL 17616675 1769345 These findings suggest that leads to increased in vitro migration and invasion , increased MMP expression , and *increased* activation of MAPK and [PI3K] activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation PIK3CA S100B 21209080 2391867 The *dependent* activation of diaphanous-1/Rac1/JNK/AP-1 , Ras/Rac1/NF-?B and [Src/Ras/PI3K/RhoA/diaphanous-1] results in the up-regulation of expression of the chemokines , CCL3 , CCL5 , and CXCL12 , whose release and activity are required for S100B to stimulate microglia migration . Positive_regulation PIK3CA SELL 20564190 2285239 Western blot analysis demonstrated that [PI3K] activation , peaking within 5 min , was *induced* by ligation of and PSGL-1 with E-selectin , and that Vav1 ( the pivotal downstream effector of PI3K signaling pathway involved in cytoskeleton regulation ) was recruited to the membrane and tyrosine phosphorylated , depending on PI3K . Positive_regulation PIK3CA SLC38A3 23376640 2747988 In addition , knockdown of STAT3 expression significantly attenuated induced [PI3K/Akt] *activation* , COX-2 expression , and cell proliferation . Positive_regulation PIK3CA SPHK1 11418646 830249 Pretreatment of cells with N , N-dimethylsphingosine ( DMS ) , an inhibitor of , or LY 294002 , an *inhibitor* of [PI3K] that acts upstream of Akt , increased the number of apoptotic cells induced by TNF-alpha in Ad5IkappaB infected Huh-7 and Hc cells . Positive_regulation PIK3CA SPHK1 24572701 2919814 In vitro , the inhibition of induced cell death in colon cancer cell lines and *attenuated* the serum dependent [PI3K/Akt] signaling . Positive_regulation PIK3CA TLR7 18227218 1871228 We show that [PI3K] is *activated* by stimulation in primary human pDCs and demonstrate , using specific inhibitors , that PI3K is required for type I IFN production by pDCs , both at the transcriptional and protein levels . Positive_regulation PIK3CA TLR7 22187458 2537228 TLR ligation leads to the activation of NF-?B and MAPKs through well defined pathways , but it has remained unclear how signaling *activates* [PI3K] , which provides an inhibitory pathway limiting TLR responses . Positive_regulation PIK3CA TLR7 22187460 2537270 signaling also *leads* to activation of [PI3K] , but the molecular mechanism is not understood . Positive_regulation PIK3CA TLR7 22895011 2682779 Here , we summarize the current understanding of signaling pathways activated by TLRs and provide our perspective on *mediated* activation of [PI3K] and its impact on regulating cellular processes . Positive_regulation PIK3CA TNF 10976992 729657 In contrast , intranuclear translocation of [PI 3-K] did not occur in *response* to the proapoptotic cytokine . Positive_regulation PIK3CA TNF 11247802 793341 The *activation* of [phosphatidylinositol (PI) 3-kinase] and Akt/protein kinase B (PKB) by and their roles on stimulation of protein synthesis were investigated in cultured neonatal rat cardiac myocytes . Positive_regulation PIK3CA TNF 11337489 827575 We also have shown that induces tyrosine phosphorylation and internalization of the overexpressed EGFR in NIH3T3 cells and the endogenously expressed EGFR in A431 cells and that the transactivation by TNF is *suppressed* by N-acetyl-l-cysteine or overexpression of an endogenous reducing molecule , thioredoxin , but not by [phosphatidylinositol 3-kinase] inhibitors and protein kinase C inhibitor . Positive_regulation PIK3CA TNF 11418646 830256 induced *activations* of [PI3K] and Akt were inhibited by DMS . Positive_regulation PIK3CA TNF 12055072 951599 In adherent neutrophils , *triggers* association of both protein kinase C (PKC)-delta and [phosphatidylinositol (PI) 3-kinase] with the p60TNFR . Positive_regulation PIK3CA TNF 14532277 1174909 Taken together , our data demonstrated that induces transactivation between Etk and VEGFR2 , and Etk directly *activates* [PI3K-Akt] angiogenic signaling independent of VEGF induced VEGFR2-PI3K-Akt signaling pathway . Positive_regulation PIK3CA TNF 14623898 1200896 Down-regulation of PTEN by NIK/NF-kappaB results in activation of the PI3K/Akt pathway and augmentation of *induced* [PI3K/Akt] stimulation . Positive_regulation PIK3CA TNF 16051251 1525207 also *activated* [phosphatidylinositol (PI)3-kinase] , as reflected by phosphorylation of Akt . Positive_regulation PIK3CA TNF 20082310 2212579 *increased* the FAK , [PI3K] , and Akt phosphorylation . Positive_regulation PIK3CA TNF 20237236 2259892 *caused* activation of NF-kappaB , MAP kinases , and [PI3K-Akt] in podocytes , whereas blockade of these molecules did not affect inhibition of RAR by TNF-alpha . Positive_regulation PIK3CA TNF 21478427 2434053 *induced* [PI3K] activation resulted in the generation of reactive oxygen species , which activated caspase-3 , a mechanism that did not operate in neutrophils without active NADPH oxidase . Positive_regulation PIK3CA TNF 22561121 2608692 Zaprinast was found to activate ERK1/2 , p38 MAPK , JNK , NF?B , and [PI3K/Akt] , and subsequently , *induce* the mRNA expressions of IL-1a , IL-1ß , , CCL2 , CCL4 , CXCL1 , CXCL2 , and CD14 . Positive_regulation PIK3CA TNF 23726836 2819761 TMP significantly inhibited *induced* phosphorylation of Syk and [PI3K] . Positive_regulation PIK3CA TNF 24089494 2848158 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed receptor 1 and *requires* activation of p38 MAPK , [phosphatidylinositol 3-kinase] , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation PIK3CA TNFSF10 21472268 2361574 Further investigation revealed that engagement *led* to the activation of [PI3K/Akt] as well as of NF-?B . Positive_regulation PIK3CA TNFSF10 21472268 2361584 Our data demonstrated that the *activation* of [PI3K/Akt] and NF-?B by is responsible for resistance to TRAIL in human gastric cancer cells . Positive_regulation PIK3CG GPR115 19494508 2091726 These results suggest that [PI3Kgamma] *activation* through PTX-sensitive as a secondary response of FcepsilonRI cross linking regulates FcepsilonRI mediated mast cell migration toward the Ag , while simultaneously activated PI3Kgamma through a PTX-insensitive pathway might have an effect on degranulation . Positive_regulation PIK3CG GPR115 19906996 2171520 By analyzing GFP tagged proteins expressed in HEK293 cells , PI3Kgamma complemented bone marrow derived mast cells ( BMMCs ) from p110gamma ( -/- ) mice , and purified recombinant proteins reconstituted to lipid vesicles , we elucidated a novel pathway of p87 dependent , *induced* [PI3Kgamma] activation . Positive_regulation PIK3CG GPR132 19494508 2091715 These results suggest that [PI3Kgamma] *activation* through PTX-sensitive as a secondary response of FcepsilonRI cross linking regulates FcepsilonRI mediated mast cell migration toward the Ag , while simultaneously activated PI3Kgamma through a PTX-insensitive pathway might have an effect on degranulation . Positive_regulation PIK3CG GPR132 19906996 2171509 By analyzing GFP tagged proteins expressed in HEK293 cells , PI3Kgamma complemented bone marrow derived mast cells ( BMMCs ) from p110gamma ( -/- ) mice , and purified recombinant proteins reconstituted to lipid vesicles , we elucidated a novel pathway of p87 dependent , induced [PI3Kgamma] *activation* . Positive_regulation PIK3CG GPR87 19494508 2091795 These results suggest that [PI3Kgamma] *activation* through PTX-sensitive as a secondary response of FcepsilonRI cross linking regulates FcepsilonRI mediated mast cell migration toward the Ag , while simultaneously activated PI3Kgamma through a PTX-insensitive pathway might have an effect on degranulation . Positive_regulation PIK3CG GPR87 19906996 2171589 By analyzing GFP tagged proteins expressed in HEK293 cells , PI3Kgamma complemented bone marrow derived mast cells ( BMMCs ) from p110gamma ( -/- ) mice , and purified recombinant proteins reconstituted to lipid vesicles , we elucidated a novel pathway of p87 dependent , *induced* [PI3Kgamma] activation . Positive_regulation PIK3R1 CCND1 16522728 1531466 We conclude that incretin induced beta-cell replication is dependent on cAMP/PKA , p42 MAPK and [PI3K] activities , which may *involve* transcriptional induction of . Positive_regulation PIK3R1 CCND1 22579115 2609561 Further investigation indicates that IL-8 stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle regulated and Cyclin B1 proteins as well as *activation* of [PI3K/Akt] and Raf/MEK/ERK , whereas IL-8 enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression . Positive_regulation PIK3R1 CD14 22561121 2608698 Zaprinast was found to activate ERK1/2 , p38 MAPK , JNK , NF?B , and [PI3K/Akt] , and subsequently , *induce* the mRNA expressions of IL-1a , IL-1ß , TNF-a , CCL2 , CCL4 , CXCL1 , CXCL2 , and . Positive_regulation PIK3R1 CHI3L1 19915670 2166580 NF1-loss was associated with lower overall MAPK and [PI3K] *activation* and relative overexpression of the mesenchymal marker . Positive_regulation PIK3R1 CTGF 16408113 1513534 P-PI3-K blockade downregulated the *stimulated* expression of [P-PI3-K] , P-Akt , and NF-kappaB but not P-p42/44 MAPK , and partially decreased the release of the above chemokines . Positive_regulation PIK3R1 CTGF 16408113 1513543 LXA ( 4 ) dose-dependently inhibited the *stimulated* mRNA expression and protein release of the above chemokines , and the expression of P-p42/44MAPK , [P-PI3-K] , P-Akt , and NF-kappaB . Positive_regulation PIK3R1 CTGF 23681229 2785480 Our studies are the first to demonstrate that reduced as an unfavorable prognosis factor *mediates* the activation of miR-18b , an oncomir directly suppresses CTGF expression , by [PI3K/AKT/C-Jun] and C-Myc and promotes cell growth of NPC . Positive_regulation PIK3R1 EPHB2 11100733 755936 The G betagamma-responsive activation induced by H2O2 is independent of ligands binding to Gi-coupled receptors , but *requires* [phosphatidylinositol-3-kinase] and Src activation . Positive_regulation PIK3R1 EPHB2 11444915 834160 Analogous to ISO , AII treatment increased and PI3-K activity , and [PI3-K] was *required* for protein synthesis . Positive_regulation PIK3R1 EPHB2 11896055 944400 negatively *regulates* the epidermal growth factor mediated interaction of Gab1 and the [phosphatidylinositol 3-kinase] . Positive_regulation PIK3R1 EPHB2 11896055 944426 HGF stimulated ERK activation increases the Gab1/PI3K association , whereas EGF stimulated activation *results* in a decrease in the tyrosine phosphorylation of Gab1 and a decreased association with the [PI3K] . Positive_regulation PIK3R1 EPHB2 12681450 1077468 This report shows that the [PI3K] inhibitors LY294002 and wortmannin block *activation* of MEK and by IL-2 in primary human T cells . Positive_regulation PIK3R1 EPHB2 16118117 1449222 The impedance by leptin of the LPS inhibitory effect on mucin synthesis was blocked by wortmannin , an *inhibitor* of [PI3K] , as well as by inhibitor , PD98059 . Positive_regulation PIK3R1 EPHB2 16754300 1571456 The impedance by PAF antagonist of the LPS induced reduction in mucin synthesis was countered by wortmannin , an *inhibitor* of [PI3K] , as well as by inhibitor , PD98059 . Positive_regulation PIK3R1 EPHB2 16782756 1625053 Taken together , these data demonstrate that mtALDH overexpression attenuates hyperoxia induced cell death in lung epithelial cells through reduction of ROS , *activation* of , and [PI3K-Akt] cell survival signaling pathways . Positive_regulation PIK3R1 EPHB2 16983494 1617420 The inhibition by PAF antagonist of the LPS induced reduction in mucin synthesis was countered by wortmannin , an *inhibitor* of [PI3K] , as well as by inhibitor , PD98059 . Positive_regulation PIK3R1 EPHB2 17540722 1778482 inhibitor PD98059 *inhibited* the [PI3K] activity , Akt phosphorylation , and lipid accumulation triggered by HG . Positive_regulation PIK3R1 EPHB2 20433817 2268187 Taken together , these results suggest that gomesin could be a useful anticancer agent , which mechanism of cytotoxicity implicates calcium entry through L-type calcium channels , *activation* of , PKC and [PI3K] signaling as well as the generation of reactive oxygen species . Positive_regulation PIK3R1 EPHB2 21129142 2401919 These findings highlight the importance of IAV induced and [PI3K] early *activation* as signalling mediators in V-ATPase stimulated endosomal acidification required for fusion . Positive_regulation PIK3R1 EPHB2 22960230 2684086 Our data suggest that dual [PI3K/mTOR] inhibitors may represent a useful pharmacological tool in the therapy of advanced adrenocortical cancer and that simultaneous inhibition of both and PI3K - mTOR pathways may be *required* to obtain a higher antiproliferative effect in this type of tumor . Positive_regulation PIK3R1 EPHB2 9892010 586572 We show that the activation of via SSTR1 is pertussis toxin sensitive and *requires* the small G protein Ras , [phosphatidylinositol 3-kinase] , the serine/threonine kinase Raf-1 , and the protein tyrosine phosphatase SHP-2 . Positive_regulation PIK3R1 F2R 11065174 746982 Thus , the PAR-1 mediated contraction is considered to be dependent on intracellular and extracellular Ca2+ , the influx of the latter being induced through activation of L-type Ca2+ channels triggered by the enhanced Na+ permeability , and that PLC and [PI3K] , in addition to PKC and TK , are involved in the *mediated* dual responses . Positive_regulation PIK3R1 FOXO1 20709952 2312827 However , whereas the [PI(3)K/Akt] regulation of Rag transcription is *mediated* by , we show in this study that the MEK/ERK pathway coordinates with the regulation of Rag by controlling the phosphorylation and turnover of E47 and its consequential binding to the Rag enhancer regions . Positive_regulation PIK3R1 FUT4 20506505 2307964 These data suggested that not only *activates* MAPK and [PI3K/Akt] signals , but also promotes the crosstalk among these signaling pathways . Positive_regulation PIK3R1 GPR115 10400698 628678 We have analyzed in Chinese hamster ovary cells the upstream mediators by which the , gastrin/CCKB , *activates* the extracellular regulated kinases ( ERKs ) and [p85/p110-phosphatidylinositol 3-kinase] ( PI 3-kinase ) pathways . Positive_regulation PIK3R1 GPR132 10400698 628667 We have analyzed in Chinese hamster ovary cells the upstream mediators by which the , gastrin/CCKB , *activates* the extracellular regulated kinases ( ERKs ) and [p85/p110-phosphatidylinositol 3-kinase] ( PI 3-kinase ) pathways . Positive_regulation PIK3R1 GPR87 10400698 628747 We have analyzed in Chinese hamster ovary cells the upstream mediators by which the , gastrin/CCKB , *activates* the extracellular regulated kinases ( ERKs ) and [p85/p110-phosphatidylinositol 3-kinase] ( PI 3-kinase ) pathways . Positive_regulation PIK3R1 IGFBP1 9325295 456817 complex with hST-3 restores IGF-I *induced* proliferation and [PI 3-K] kinase activity in these cells . Positive_regulation PIK3R1 IL1B 16567807 1562241 Western blot analysis combined with I ( GABA ) recording and confocal images of GABA ( A ) Rs in oocytes showed that *stimulates* the IL-1RI dependent [phosphatidylinositol 3-kinase] activation and the consequent facilitation of phospho-Akt mediated insertion of GABA ( A ) Rs into the cell surface . Positive_regulation PIK3R1 IL1B 17299794 1718844 Src , PDGFR , and [PI3K/Akt] *mediated* the effects of because pretreatment with PP1 , AG1296 , and wortmannin also abrogated IL-1beta stimulated Src , PDGFR , and Akt phosphorylation , respectively . Positive_regulation PIK3R1 IL1B 17390080 1716171 Addition of triptolide did not suppress activation of p38 MAPK , JNK , or [PI3K] in *response* to . Positive_regulation PIK3R1 IL1B 17504920 1744647 In summary , results presented herein demonstrate that *stimulates* [PI3K/PKB-] , P70S6K- , and ERK1/2 dependent pathways in rat Sertoli cells . Positive_regulation PIK3R1 INPP4B 24288008 2926683 We further demonstrate that *regulates* [PI3K/Akt] signaling and exerts a tumor suppressor effect , impacting the proliferative , invasive , and tumorigenic capacity of melanoma cells . Positive_regulation PIK3R1 IRS4 20079766 2225645 We report also Ins induced [PI3-K] activation *mediated* by . Positive_regulation PIK3R1 ITGAL 11359803 816335 mediated costimulation of CD8+ T cell proliferation *requires* [phosphatidylinositol 3-kinase] activity . Positive_regulation PIK3R1 ITGB2 14960575 1227761 We have identified Vav , a guanine nucleotide exchange factor for Rac-1 , and PI3K/Akt , as regulators of the activation and inactivation phases of the activity of Rac-1 , respectively , in the context of LFA-1 signaling based on the following experimental evidence : ( i ) *induced* activation of Vav and [PI3K/Akt] with kinetics consistent with a regulatory role for these molecules on Rac-1 , ( ii ) overexpression of a constitutively active Vav mutant induces activation of Rac independently of LFA-1 stimulation whereas overexpression of a dominant negative Vav mutant blocks LFA-1 mediated Rac activation , ( iii ) pharmacological inhibition of PI3K/Akt prevented the fall in the activity of Rac-1 after its initial activation but had no effect on Vav activity , and ( iv ) overexpression of a dominant negative or a constitutively active Akt-1 induced or inhibited , respectively , Rac-1 activity . Positive_regulation PIK3R1 LAMB3 18283320 1878368 The expression of laminin-332 in 126 resected oesophageal squamous cell carcinoma ( ESCC ) specimens was immunohistochemically examined to determine its associations with the clinicopathological characteristics , and the effect of on the invasiveness and the [PI3K] *activation* was assessed by in vitro experiments using ESCC cell lines ( ESCCs ) . Positive_regulation PIK3R1 MAP2K6 12114408 964069 Our results suggest the combination of paclitaxel and inhibitor *leads* to down-regulation of the [PI3K-Akt] signaling in addition to the proapoptotic effects of paclitaxel and MEK inhibitor alone . Positive_regulation PIK3R1 MAP2K6 12681450 1077475 This report shows that the [PI3K] inhibitors LY294002 and wortmannin block *activation* of and ERK by IL-2 in primary human T cells . Positive_regulation PIK3R1 MAP2K6 15618457 1387802 The [PI3K] *inhibitors* wortmannin and LY-294002 and an Akt inhibitor , 1-L-6-hydroxymethyl-chiro-inositol 2- ( R ) -2-O-methyl-3-O-octadecylcarbonate , but not a inhibitor PD-98059 , blocked isoproterenol mediated eosinophil survival . Positive_regulation PIK3R1 MAP2K6 21769916 2494854 In TGW cells , PD98059 , a inhibitor , but not SB203580 ( a p38 MAPK inhibitor ) and LY294002 ( a [PI3K] *inhibitor* ) inhibited GDNF induced GAP43 expression , suggesting the MEK/ERK pathway has a major role in GDNF induced GAP43 transcription . Positive_regulation PIK3R1 MAP2K6 24442130 2918080 Inhibition of these pathways utilizing PF-04691502 , a [PI3K] and mTOR *inhibitor* , and PD-0325901 , a inhibitor , slowed the tumor growth of PDX models of bladder cancer . Positive_regulation PIK3R1 MAP2K6 9595422 505974 The effect of ET-1 in suppressing apoptosis was unaffected by any of the following reagents : a phospholipase C inhibitor ( U73122 ) , a tyrosine kinase inhibitor ( ST638 ) , an inhibitor ( PD98059 ) , a [phosphatidylinositol-3 kinase] *inhibitors* ( wortmannin , LY294002 ) . Positive_regulation PIK3R1 MMP7 21273532 2419764 Collectively , these findings indicate that ACh induced cell migration is mediated by *mediated* release of HBEGF , an ERBB ligand that activates ERBB1 and downstream ERK and [PI3K] signaling . Positive_regulation PIK3R1 NGFR 22880054 2641729 Whereas Src kinases are often required for Syk activation , we show here that [PI3K/Akt] *activation* and autocrine IL-10 production by involves the Src family kinase Fyn . Positive_regulation PIK3R1 PECAM1 24030383 2857125 Activation of signaling *results* in its tyrosine phosphorylation , the recruitment and activation of tyrosine phosphatase SHP-2 , the subsequent binding of phosphoinositol 3-kinase (PI3K) , and diminished [PI3K] signaling . Positive_regulation PIK3R1 PLAT 17498240 1739847 Consistent with neurotrophic effects , *activated* Raf-K/ERK , PKC and [PI3-K/Akt] , 5-60 min after treatment . Positive_regulation PIK3R1 PLAT 23562854 2778003 Glucose deprivation induced activation of [PI3K-Akt-GSK3ß] , p38 and AMPK , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation PIK3R1 PLAU 10995743 752345 We demonstrate that *induces* [PI3-K] activation , which is abolished in VSMC expressing the dominant negative form of Tyk2 . Positive_regulation PIK3R1 PLAU 10995743 752347 The regulatory subunit p85 of PI3-K co-immunoprecipitates with Tyk2 but not with Jak1 , Jak2 , or Jak3 , and stimulation *increases* the [PI3-K] activity in Tyk2 immunoprecipitates . Positive_regulation PIK3R1 PLAU 10995743 752351 We provide evidence that the Tyk2 mediated [PI3-K] activation in *response* to is required for VSMC migration . Positive_regulation PIK3R1 PLAU 12545160 1051061 Downregulation of *inhibits* migration and [PI3k/Akt] signaling in glioblastoma cells . Positive_regulation PIK3R1 PODXL 17616675 1769346 These findings suggest that leads to increased in vitro migration and invasion , increased MMP expression , and *increased* activation of MAPK and [PI3K] activity in MCF7 and PC3 cells through its ability to form a complex with ezrin . Positive_regulation PIK3R1 S100B 21209080 2391869 The *dependent* activation of diaphanous-1/Rac1/JNK/AP-1 , Ras/Rac1/NF-?B and [Src/Ras/PI3K/RhoA/diaphanous-1] results in the up-regulation of expression of the chemokines , CCL3 , CCL5 , and CXCL12 , whose release and activity are required for S100B to stimulate microglia migration . Positive_regulation PIK3R1 SELL 20564190 2285241 Western blot analysis demonstrated that [PI3K] activation , peaking within 5 min , was *induced* by ligation of and PSGL-1 with E-selectin , and that Vav1 ( the pivotal downstream effector of PI3K signaling pathway involved in cytoskeleton regulation ) was recruited to the membrane and tyrosine phosphorylated , depending on PI3K . Positive_regulation PIK3R1 SLC38A3 23376640 2747989 In addition , knockdown of STAT3 expression significantly attenuated *induced* [PI3K/Akt] activation , COX-2 expression , and cell proliferation . Positive_regulation PIK3R1 SPHK1 11418646 830251 Pretreatment of cells with N , N-dimethylsphingosine ( DMS ) , an inhibitor of , or LY 294002 , an *inhibitor* of [PI3K] that acts upstream of Akt , increased the number of apoptotic cells induced by TNF-alpha in Ad5IkappaB infected Huh-7 and Hc cells . Positive_regulation PIK3R1 SPHK1 24572701 2919815 In vitro , the inhibition of induced cell death in colon cancer cell lines and *attenuated* the serum dependent [PI3K/Akt] signaling . Positive_regulation PIK3R1 TLR7 18227218 1871238 We show that [PI3K] is *activated* by stimulation in primary human pDCs and demonstrate , using specific inhibitors , that PI3K is required for type I IFN production by pDCs , both at the transcriptional and protein levels . Positive_regulation PIK3R1 TLR7 22187458 2537238 TLR ligation leads to the activation of NF-?B and MAPKs through well defined pathways , but it has remained unclear how signaling *activates* [PI3K] , which provides an inhibitory pathway limiting TLR responses . Positive_regulation PIK3R1 TLR7 22187460 2537280 signaling also *leads* to activation of [PI3K] , but the molecular mechanism is not understood . Positive_regulation PIK3R1 TLR7 22895011 2682789 Here , we summarize the current understanding of signaling pathways activated by TLRs and provide our perspective on *mediated* activation of [PI3K] and its impact on regulating cellular processes . Positive_regulation PIK3R1 TNF 10976992 729658 In contrast , intranuclear translocation of [PI 3-K] did not occur in *response* to the proapoptotic cytokine . Positive_regulation PIK3R1 TNF 11247802 793342 The *activation* of [phosphatidylinositol (PI) 3-kinase] and Akt/protein kinase B (PKB) by and their roles on stimulation of protein synthesis were investigated in cultured neonatal rat cardiac myocytes . Positive_regulation PIK3R1 TNF 11337489 827576 We also have shown that induces tyrosine phosphorylation and internalization of the overexpressed EGFR in NIH3T3 cells and the endogenously expressed EGFR in A431 cells and that the transactivation by TNF is *suppressed* by N-acetyl-l-cysteine or overexpression of an endogenous reducing molecule , thioredoxin , but not by [phosphatidylinositol 3-kinase] inhibitors and protein kinase C inhibitor . Positive_regulation PIK3R1 TNF 11418646 830257 *induced* activations of [PI3K] and Akt were inhibited by DMS . Positive_regulation PIK3R1 TNF 12055072 951600 In adherent neutrophils , *triggers* association of both protein kinase C (PKC)-delta and [phosphatidylinositol (PI) 3-kinase] with the p60TNFR . Positive_regulation PIK3R1 TNF 14532277 1174912 Taken together , our data demonstrated that induces transactivation between Etk and VEGFR2 , and Etk directly *activates* [PI3K-Akt] angiogenic signaling independent of VEGF induced VEGFR2-PI3K-Akt signaling pathway . Positive_regulation PIK3R1 TNF 14623898 1200899 Down-regulation of PTEN by NIK/NF-kappaB results in activation of the PI3K/Akt pathway and augmentation of *induced* [PI3K/Akt] stimulation . Positive_regulation PIK3R1 TNF 16051251 1525208 also *activated* [phosphatidylinositol (PI)3-kinase] , as reflected by phosphorylation of Akt . Positive_regulation PIK3R1 TNF 20082310 2212580 *increased* the FAK , [PI3K] , and Akt phosphorylation . Positive_regulation PIK3R1 TNF 20237236 2259893 *caused* activation of NF-kappaB , MAP kinases , and [PI3K-Akt] in podocytes , whereas blockade of these molecules did not affect inhibition of RAR by TNF-alpha . Positive_regulation PIK3R1 TNF 21478427 2434054 induced [PI3K] *activation* resulted in the generation of reactive oxygen species , which activated caspase-3 , a mechanism that did not operate in neutrophils without active NADPH oxidase . Positive_regulation PIK3R1 TNF 22561121 2608697 Zaprinast was found to activate ERK1/2 , p38 MAPK , JNK , NF?B , and [PI3K/Akt] , and subsequently , *induce* the mRNA expressions of IL-1a , IL-1ß , , CCL2 , CCL4 , CXCL1 , CXCL2 , and CD14 . Positive_regulation PIK3R1 TNF 23726836 2819762 TMP significantly inhibited *induced* phosphorylation of Syk and [PI3K] . Positive_regulation PIK3R1 TNF 24089494 2848159 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed receptor 1 and *requires* activation of p38 MAPK , [phosphatidylinositol 3-kinase] , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation PIK3R1 TNFSF10 21472268 2361575 Further investigation revealed that engagement *led* to the activation of [PI3K/Akt] as well as of NF-?B . Positive_regulation PIK3R1 TNFSF10 21472268 2361585 Our data demonstrated that the *activation* of [PI3K/Akt] and NF-?B by is responsible for resistance to TRAIL in human gastric cancer cells . Positive_regulation PIK3R4 EPHB2 11445578 850499 *regulates* the hepatocyte growth factor mediated interaction of Gab1 and the [phosphatidylinositol 3-kinase] . Positive_regulation PIK3R4 EPHB2 16844778 1592177 Activated Src phosphorylates Cbl , which recruits the p85 subunit of phosphatidylinositol 3-kinase , resulting in [phosphatidylinositol 3-kinase] activation and eventually the *activation* of Akt and . Positive_regulation PIK3R4 EPHB2 19479862 2097679 The MAPKs p38 , JNK , and were necessary for IL-6 production , but [phosphatidylinositol 3-kinase] ( PI 3-kinase ) was *required* for selective CCL5 induction . Positive_regulation PIK3R4 FAS 11729103 897049 Instead , the early inhibition of p38 MAPK concurred with a induced *activation* of [phosphatidylinositol 3-kinase] , inhibition of which reduced apoptosis . Positive_regulation PIK3R4 FAS 11729103 897064 We conclude that p38 MAPK activity represents a survival signal that is inactivated transiently during both spontaneous and Fas induced apoptosis , whereas *induced* [phosphatidylinositol 3-kinase] activity is a proapoptotic signal in isolated human neutrophils . Positive_regulation PIK3R4 FAS 19204002 2049789 The up-regulation of both SREBP and by NS4B protein *required* [phosphatidylinositol 3-kinase] activity . Positive_regulation PIK3R4 S1PR3 15334188 1291026 Finally , S1P also protects endothelial cells from apoptosis through *activation* of [phosphatidylinositol 3-kinase/Akt/eNOS] via S1P(1) and receptors . Positive_regulation PIK3R4 SPHK1 16622018 1551524 Macrophage 's proinflammatory response to a mycobacterial infection is dependent on mediated *activation* of phosphatidylinositol phospholipase C , protein kinase C , ERK1/2 , and [phosphatidylinositol 3-kinase] . Positive_regulation PIK3R4 TNF 11266376 796728 There has been recent speculation on the *activation* of [phosphatidylinositol 3-kinase] ( PI 3-kinase ) by and its role in the regulation of genes controlled by NF-kappaB . Positive_regulation PIK3R4 TNF 11356844 834434 *Activation* of [phosphatidylinositol (PI) 3-kinase/Akt] signaling by activates IKK and NF-kappaB . Positive_regulation PIK3R4 TNF 14592823 1209473 Furthermore , mediated *activation* of [phosphatidylinositol 3-kinase] ( PI 3-kinase ) represents an additional essential signaling component in this process as demonstrated by studies with its inhibitor wortmannin as well as by analysis of the phosphorylation of AKT kinase . Positive_regulation PIK3R4 TNF 15722197 1374648 The *activation* of NF-kappaB and [phosphatidylinositol-3 (PI3) kinase] by and TRAIL overrides the pro-apoptotic effects of these ligands in carcinoma cells and hinders their therapeutic application . Positive_regulation PIK3R4 TNF 23538493 2788593 In addition , *induced* a downregulation of claudin-1 , claudin-2 , claudin-4 , and occludin as well as activation of [phosphatidylinositol 3-kinase] signaling in T-84 but not Caco-2 cells , which was reversed by adalimumab . Positive_regulation PIK3R4 TNFSF10 15722197 1374649 The *activation* of NF-kappaB and [phosphatidylinositol-3 (PI3) kinase] by TNF-alpha and overrides the pro-apoptotic effects of these ligands in carcinoma cells and hinders their therapeutic application . Positive_regulation PIM1 EPHB2 21147132 2378319 Inhibitors of p38MAPK and *attenuated* the SS-induced expression of [Pim-1] . Positive_regulation PIM3 TNF 21181358 2358323 Furthermore , H ( 2 ) O ( 2 ) but not *up-regulated* the [Pim-3] gene expression in cultured cardiomyocytes . Positive_regulation PIN1 TLR7 21743479 2456122 We found here that and TLR9 *activated* the isomerase [Pin1] , which then bound to IRAK1 ; Positive_regulation PIN1 TNF 20956805 2357369 We first showed that [Pin1] is expressed in neutrophil cytosol and that its activity is markedly *enhanced* by . Positive_regulation PIP SRGN 2822001 78668 Mg2+ ( 0.5 mM ) potentiated p [ NH ] *stimulated* breakdown of [PIP2] . Positive_regulation PIP5K1A GPR115 11431481 850213 Thus , these findings suggest that stimulation of a ( PAR1 ) *leads* to the sequential activation of G alpha ( q ) , Rac , Rho , and [PIP5K I alpha] . Positive_regulation PIP5K1A GPR132 11431481 850202 Thus , these findings suggest that stimulation of a ( PAR1 ) *leads* to the sequential activation of G alpha ( q ) , Rac , Rho , and [PIP5K I alpha] . Positive_regulation PIP5K1A GPR87 11431481 850282 Thus , these findings suggest that stimulation of a ( PAR1 ) *leads* to the sequential activation of G alpha ( q ) , Rac , Rho , and [PIP5K I alpha] . Positive_regulation PITX2 AXIN2 17404238 1721620 Conditional beta cell expression of , a potent negative regulator of Wnt signaling , *led* to reduced [Pitx2] and Cyclin D2 expression by beta cells , resulting in reduced neonatal beta cell expansion and mass and impaired glucose tolerance . Positive_regulation PIWIL4 TDRKH 23714778 2806507 is a mitochondrial protein often juxtaposed to pi-bodies and piP-bodies and is *required* for Tdrd1 cytoplasmic localization and [Miwi2] nuclear localization . Positive_regulation PKD1 TNF 21292998 2410192 , while having no detectable effect on the activation of PKD when added alone , *augmented* [PKD] activation stimulated by LPA , as measured by PKD autophosphorylation at Ser ( 910 ) . Positive_regulation PKD2 EPHB2 19098310 2042018 In addition , we found that activation was *induced* by [PKD2] overexpression via B-Raf signaling , providing a possible molecular mechanism of cystogenesis . Positive_regulation PKD2 GPR115 18323855 1897764 [TRPP2/TRPC1] is activated in *response* to activation and shows a pattern of single-channel conductance , amiloride sensitivity and ion permeability distinct from that of TRPP2 or TRPC1 alone . Positive_regulation PKD2 GPR115 19244406 2093777 Functional studies in cell culture show that [TRPP2] can be activated in *response* to mechanical cues ( fluid shear stress ) and/or receptor tyrosine kinase ( RTK ) and activation at the cell surface . Positive_regulation PKD2 GPR132 18323855 1897753 [TRPP2/TRPC1] is activated in *response* to activation and shows a pattern of single-channel conductance , amiloride sensitivity and ion permeability distinct from that of TRPP2 or TRPC1 alone . Positive_regulation PKD2 GPR132 19244406 2093766 Functional studies in cell culture show that [TRPP2] can be activated in *response* to mechanical cues ( fluid shear stress ) and/or receptor tyrosine kinase ( RTK ) and activation at the cell surface . Positive_regulation PKD2 GPR87 18323855 1897833 [TRPP2/TRPC1] is activated in *response* to activation and shows a pattern of single-channel conductance , amiloride sensitivity and ion permeability distinct from that of TRPP2 or TRPC1 alone . Positive_regulation PKD2 GPR87 19244406 2093846 Functional studies in cell culture show that [TRPP2] can be activated in *response* to mechanical cues ( fluid shear stress ) and/or receptor tyrosine kinase ( RTK ) and activation at the cell surface . Positive_regulation PKD2 TNF 21292998 2410193 , while having no detectable effect on the activation of PKD when added alone , *augmented* [PKD] activation stimulated by LPA , as measured by PKD autophosphorylation at Ser ( 910 ) . Positive_regulation PKD3 TNF 21292998 2410194 , while having no detectable effect on the activation of PKD when added alone , *augmented* [PKD] activation stimulated by LPA , as measured by PKD autophosphorylation at Ser ( 910 ) . Positive_regulation PKM DAPK1 21725354 2546589 Notably , transfection of cells , with a truncated DAPk lacking the KD , elevated endogenous PKM2 activity , suggesting that [PKM2] *activation* by occurs independently of its kinase activity . Positive_regulation PKM EGLN3 21620138 2436373 Interaction of PKM2 with *enhances* [PKM2] binding to HIF-1a and PKM2 coactivator function . Positive_regulation PKN1 ANGPT1 16049136 1459905 Overexpression of antioxidants ( superoxide dismutase and catalase ) and Rac1N17 , as well as preincubation with selective inhibitors of NADPH oxidase augmented basal p38 phosphorylation , inhibited *induced* [PAK-1] phosphorylation and potentiated Ang-1 induced Erk1/2 phosphorylation but had no influence on AKT and SAPK/JNK phosphorylation by Ang-1 . Positive_regulation PKN1 EPHB2 15542607 1360697 Adhesion stimulates direct PAK1/ERK2 association and leads to *dependent* [PAK1] Thr212 phosphorylation . Positive_regulation PKN1 EPHB2 20526801 2320124 In this study , we investigated whether *regulates* [Rac1/Pak1] signaling and is critically linked to MB cell migration . Positive_regulation PKN1 EPHB2 20526801 2320147 However , specific depletion of Pak1 by siRNA has no effect on PDGF induced ERK phosphorylation , indicating that in MB cells ERK signaling is Pak1 independent , but PDGF induced migration is dependent on *mediated* activation of [Pak1] . Positive_regulation PKN1 EPHB2 22981863 2688689 LAT independent activation via Bam32-PLC-?1-Pak1 complexes : GTPase independent [Pak1] *activation* . Positive_regulation PKN1 SPHK1 18644866 1954718 was *required* for heregulin induced migration , lamellipodia formation , activation of [PAK1] , and subsequent FLNa phosphorylation . Positive_regulation PKN1 TNF 12089369 959717 stimulation *increased* association of [PAK1] with Akt . Positive_regulation PKP1 INS 23444369 2781136 stimulation *induced* the phosphorylation of [plakophilin 1] , which correlated with reduced intercellular adhesion and an increased activity of plakophilin 1 in the stimulation of translation . Positive_regulation PKP3 PKP1 21947748 2642504 In breast cancer , compared with normal tissue , and PKP2 expressions were indifferent ( P > 0.05 ) , but [PKP3] expression was significantly *increased* in breast cancer ( P = 0.0014 ) . Positive_regulation PLA2G16 TNF 16720829 1585002 Likewise , the *inducing* activity of diphosphoryl lipid [A (DPLA)] was also sensitive to boiling . Positive_regulation PLA2G1B ALOX5 18544894 1929095 Quinacrine , a [phospholipase A(2)] *inhibitor* , indomethacin , and AA861 , a <5-lipoxygenase> inhibitor , inhibited the contraction . Positive_regulation PLA2G1B ALOX5 19754384 2140389 In addition , novel substances such as HDL related agents , cyclopentenone prostaglandins , lipoprotein associated [phospholipase A(2)] *inhibitors* , <5-lipoxygenase> pathway inhibitors , acyl CoA : cholesterol acyltransferase inhibitors , analogues of probucol and lysophosphatidic acid antagonists have been developed for the treatment of atherosclerosis as a consequence of their actions on oxidative stress and inflammation . Positive_regulation PLA2G1B ALOX5 7592874 334457 Inhibition of <5-lipoxygenase> with either eicosatetraynoic acid or zileuton *prevented* the AA-induced increase in [PLA2] activity but had no effect on the response induced by LTB4 . Positive_regulation PLA2G1B ALOX5 8189063 257002 Ag , but not [PLA2] , *induces* the translocation of <5-LO> to cellular membranes and the formation of 5-LO products . Positive_regulation PLA2G1B ANGPT1 14584044 1187140 However , *had* no effect on VEGF induced activation of [phospholipase A(2)] or the release of arachidonic acid . Positive_regulation PLA2G1B BPI 3300783 76496 To explore further the determinants of hydrolysis we measured the binding of 125I labeled [phospholipase A2] to E. coli in the *presence* and absence of . Positive_regulation PLA2G1B BPI 7929350 274498 Substitution of Ser for Arg-7 +/- Gln for Lys-15 caused , respectively , about a 10- and 25-fold reduction in *dependent* [PLA2] binding and activity to E. coli , but had no effect on hydrolysis of PL of autoclaved E. coli or dispersions of purified PL. PL degradation during phagocytosis was increased after pretreatment of E. coli ( or PMN ) with wild-type PLA2 followed by removal of unbound PLA2 . Positive_regulation PLA2G1B BPI 8141787 252239 ' bound with high affinity to Salmonella typhimurium cells ( apparent Kd = 36 nM ) , permeabilized their outer membranes to actinomycin D , specifically *activated* a synovial fluid [phospholipase A2] and showed potent bactericidal activity . Positive_regulation PLA2G1B CAPN8 24323421 2880236 A metabolic sequence including NMDA receptor activation , *activation* of [phospholipase A2] and production of free radicals , and also the activation of are shown to be critical . Positive_regulation PLA2G1B EDN2 2159883 133206 induced *activation* of phospholipase C and [phospholipase A2] signal transduction pathways ( EC50 approximately 5-8 nM for both ) in hVSMC apparently proceed in an independent parallel manner rather than a sequential one . Positive_regulation PLA2G1B EDN2 2492195 105551 *Activation* of [phospholipase A2] by in cultured vascular smooth muscle cells . Positive_regulation PLA2G1B EDN2 2492195 105557 The data herein implicate *activation* of [phospholipase A2] by with subsequent metabolism of arachidonic acid via the lipoxygenase pathway . Positive_regulation PLA2G1B EDN2 8262973 239231 has been shown to *activate* [phospholipase A2] and release arachidonic acid in isolated rat hearts . Positive_regulation PLA2G1B EDN2 8526939 336627 *Activation* of [phospholipase A2] by the human receptor in Chinese hamster ovary cells involves Gi protein mediated calcium influx . Positive_regulation PLA2G1B EPHB2 12920210 1130941 We also found that *mediated* cytosolic [PLA2] activity is essential for superoxide generation . Positive_regulation PLA2G1B FAS 7540278 307214 Bcl-x and Bcl-2 inhibit TNF and induced apoptosis and *activation* of [phospholipase A2] in breast carcinoma cells . Positive_regulation PLA2G1B FAS 8557994 348690 Overexpression of A20 also inhibits TNF induced activation of phospholipase A2 in a similar dose dependent manner as it inhibits TNF mediated apoptosis , whereas it does not affect the *activation* of [phospholipase A2] by . Positive_regulation PLA2G1B FAS 8846779 338013 cross linking *resulted* also in ERK-2 activation and in [phospholipase A2 (PLA2)] induction , independently of the PC-PLC/aSMase pathway . Positive_regulation PLA2G1B FUT4 2739065 114665 *suppressed* a decrease in the blood pressure , activations of [phospholipase A2] and prekallikrein , but had no effect on serum TXB2 , 6-keto-PGF1 alpha , C3 and CH50 compared with the LPS alone group . Positive_regulation PLA2G1B GPR115 17595527 1764808 The signaling pathway for guanylin peptides in the kidney involves an unknown which *activates* [PLA(2)] and increases arachidonic acid as well . Positive_regulation PLA2G1B GPR132 17595527 1764797 The signaling pathway for guanylin peptides in the kidney involves an unknown which *activates* [PLA(2)] and increases arachidonic acid as well . Positive_regulation PLA2G1B GPR87 17595527 1764877 The signaling pathway for guanylin peptides in the kidney involves an unknown which *activates* [PLA(2)] and increases arachidonic acid as well . Positive_regulation PLA2G1B IL1B 10199864 605382 COX-2 and cytosolic [PLA2] mediate *induced* cAMP production in human vascular smooth muscle cells . Positive_regulation PLA2G1B IL1B 10438477 634834 Type II-secreted [phospholipase A(2)] ( type II-sPLA ( 2 ) ) is expressed in smooth muscle cells during atherosclerosis or in *response* to . Positive_regulation PLA2G1B IL1B 10675243 667696 The 85 kDa [phospholipase A2] was *induced* by , whereas there was no apparent change in secretory phospholipase A2 enzyme concentrations . Positive_regulation PLA2G1B IL1B 10791956 714419 *Induction* of the transcription of secreted type IIA [phospholipase A(2)] gene by in chondrocytes absolutely requires C/EBPbeta and C/EBPdelta factors but does not involve NF-kappaB . Positive_regulation PLA2G1B IL1B 10843735 700285 The regulatory effects of interferon (IFN)-gamma and IL-4 on *induced* COX , [PLA(2)isoforms] expression and terminal delayed PGE ( 2 ) generation were examined in three types of human fibroblasts . Positive_regulation PLA2G1B IL1B 10843735 700290 IL-1beta also stimulated expression of cPLA(2)and COX-2 only , while constitutive and *induced* type IIA and type V secretory [PLA(2)s] ( sPLA(2)s ) expression could not be detected . Positive_regulation PLA2G1B IL1B 11132768 760226 In contrast , DEX inhibited *induced* [PLA2] activity but not constitutive activity . Positive_regulation PLA2G1B IL1B 11407686 825869 significantly *up-regulated* [PLA2] activity ( P < 0.005 ) and cPLA2 mRNA expression while anti-MIF monoclonal antibody ( mAb ) significantly inhibited this IL-1beta induced PLA2 activity ( P < 0.02 ) . Positive_regulation PLA2G1B IL1B 11571275 875435 Group IIa phospholipase A(2) ( GIIa [PLA(2)] ) is released by some cells in *response* to . Positive_regulation PLA2G1B IL1B 11571275 875439 The purpose of this study was to determine whether would *stimulate* the synthesis and release of GIIa [PLA(2)] from cardiomyocytes , and to define the role of p38 MAPK and cytosolic PLA(2) in the regulation of this process . Positive_regulation PLA2G1B IL1B 11571275 875440 also *stimulated* a progressive increase in cellular and extracellular GIIa [PLA(2)] protein levels and increased extracellular PLA(2) activity 70-fold . Positive_regulation PLA2G1B IL1B 11571275 875469 These results provide direct evidence that p38 MAPK activation was necessary for *induced* synthesis and release of GIIa [PLA(2)] by cardiomyocytes . Positive_regulation PLA2G1B IL1B 12562859 1064212 We established that AA potentiates *induced* expression of the type IIA secreted [phospholipase A2] ( sPLA2 ) gene , whereas EPA and DHA reduce this stimulation . Positive_regulation PLA2G1B IL1B 1333514 204409 In summary , these studies suggest that *mediated* endothelial cell [phospholipase A2] activity and prostacyclin synthesis occur via a novel transducing pathway that does not involve early activation of phospholipase C , phospholipase D , or adenylate cyclase . Positive_regulation PLA2G1B IL1B 1577722 187476 and forskolin *induce* prostaglandin E2 release as well as 14-kDa group II [phospholipase A2] gene expression and secretion of the enzyme from rat glomerular mesangial cells . Positive_regulation PLA2G1B IL1B 1577722 187480 However , under conditions where the *induced* expression of group II [phospholipase A2] is fully suppressed by transforming growth factor-beta 2 , the growth factor itself stimulated prostaglandin E2 synthesis by a mechanism apparently not involving group II phospholipase A2 . Positive_regulation PLA2G1B IL1B 1618301 191315 Antisera against group II phospholipase A2 totally blocked the *induced* [phospholipase A2] activity , but antisera against group I phospholipase A2 did not . Positive_regulation PLA2G1B IL1B 17325654 1719873 FTY720 suppresses *induced* secretory [phospholipase A2] expression in renal mesangial cells by a transcriptional mechanism . Positive_regulation PLA2G1B IL1B 17908795 1824368 Inhibition of *induced* group IIA secretory [phospholipase A2] expression by peroxisome proliferator activated receptors ( PPARs ) in rat vascular smooth muscle cells : cooperation between PPARbeta and the proto-oncogene BCL-6 . Positive_regulation PLA2G1B IL1B 1936271 170275 The tyrosine kinase inhibitor genistein dose-dependently antagonized the inhibitory effect of PDGF-BB on *stimulated* [PLA2] secretion , thus suggesting that tyrosine phosphorylation may be required for PDGF-BB inhibition of PLA2 gene expression in mesangial cells . Positive_regulation PLA2G1B IL1B 19675207 2150734 release at a low TLO dose *requires* potassium efflux , calcium influx , and the activities of calcium independent [PLA(2)] , caspase-1 , and cathepsin B . Positive_regulation PLA2G1B IL1B 1989605 152317 The time dependent increase of [phospholipase A2] activity in both cells and culture medium upon *stimulation* with plus forskolin is accompanied with elevated 14 kDa phospholipase A2 protein levels . Positive_regulation PLA2G1B IL1B 2803314 120007 *stimulates* [phospholipase A2] mRNA synthesis in rabbit articular chondrocytes . Positive_regulation PLA2G1B IL1B 7663391 321844 *stimulates* [phospholipase A2] activity in rat C6 glioma cells . Positive_regulation PLA2G1B IL1B 7663391 321845 These results suggested that may *stimulate* [phospholipase A2] activity through its gene activation . Positive_regulation PLA2G1B IL1B 7945342 276519 From these observations , we suggest that first *induces* the synthesis and release of Type II inflammatory [phospholipase A2] , which in turn stimulates the expression of Gi2 alpha gene via production of various lipid mediators . Positive_regulation PLA2G1B IL1B 8224206 234766 *induces* gene expression and secretion of the secretory [phospholipase A2] ( sPLA2 ) and prostaglandin E2 ( PGE2 ) release from rat mesangial cells . Positive_regulation PLA2G1B IL1B 8273584 239504 *induces* cytosolic [PLA2] in parallel with prostaglandin E2 in rheumatoid synovial fibroblasts . Positive_regulation PLA2G1B IL1B 8654401 358798 [PLA2] expression in TBSMC cultures was markedly *increased* by tumour-necrosis factor (TNF) alpha ( 130-fold ) and ( 7.4-fold ) . Positive_regulation PLA2G1B IL1B 8654401 358800 Northern blot analysis showed that TNF alpha and *increased* both [PLA2] and inducible cyclooxygenase ( Cox-2 ) mRNA transcription . Positive_regulation PLA2G1B IL1B 9061002 417819 Half-life of *induced* group II [phospholipase A2] in rat mesangial cells . Positive_regulation PLA2G1B IL1B 9109430 424829 The present study showed that *induced* the sustained synthesis of prostaglandin E2 and a parallel increase in type II sPLA2 gene expression ( assessed by enzymatic activity and Northern blot analysis ) , but no increase in cytosolic PLA2 gene expression ( assessed by Northern and Western blot analysis ) or cytosolic [PLA2] activity in rabbit articular chondrocytes . Positive_regulation PLA2G1B IL1B 9124287 419505 *stimulates* [phospholipase A2] activity in adult rat ventricular myocytes . Positive_regulation PLA2G1B IL1B 9124287 419508 Additionally , IL-1beta caused an increase in arachidonic acid release in 20 min. Pretreatment with E-6- ( bromomethylene ) tetrahydro-3- ( 1-naphthalenyl ) -2H-pyran-2-one , a selective Ca2+ independent PLA2 inhibitor , blocked *induced* increases in both [PLA2] activity and arachidonic acid release . Positive_regulation PLA2G1B IL1B 9124287 419509 These results show that , via activation of its receptors , *stimulates* specifically membrane associated Ca2+ independent plasmalogen-selective [PLA2] in rat ventricular myocytes . Positive_regulation PLA2G1B IL1B 9208149 440913 Suppression by cyclosporin A of *induced* expression of group II [phospholipase A2] in rat renal mesangial cells . Positive_regulation PLA2G1B IL1B 9208149 440914 Previously we found that the nuclear transcription factor kappa B ( NF kappa B ) is an essential component of the *dependent* upregulation of [PLA2] gene transcription . Positive_regulation PLA2G1B IL1B 9227468 443234 *caused* a concentration dependent and a time dependent increase in PLAP levels as well as in [PLA2] activity , with the maximal increase observed at an IL-1 beta concentration between 10 and 30 ng/ml reached in 2-10 min . Positive_regulation PLA2G1B IL1B 9353419 461549 Exposure of human rheumatoid synovial fibroblasts ( RSF ) to *results* in the coordinate up-regulation of 85-kDa [phospholipase A2 (PLA2)] and mitogen-inducible cyclooxygenase ( COX II ) and subsequent biosynthesis of prostaglandin E2 ( PGE2 ) . Positive_regulation PLA2G1B IL1B 9555020 499670 Platelet derived growth factor (PDGF)-BB potently inhibits secretion of and forskolin *induced* group II [PLA2] activity . Positive_regulation PLA2G1B IL1B 9555020 499673 Basic fibroblast growth factor (bFGF) virtually does not inhibit *stimulated* group II [PLA2] activity , but markedly inhibits forskolin induced expression of group II PLA2 activity . Positive_regulation PLA2G1B IL1B 9746498 533321 TNF-alpha and together *enhanced* synergistically cytosolic and membrane [PLA2] activities and arachidonic acid release that were blocked differentially by MAFP and BEL , respectively , and inhibited completely by MAFP plus BEL . Positive_regulation PLA2G1B ITGB2 9590257 504797 Type II [phospholipase A2] ( PLA2-II ) also *induces* translocation of from secretory vesicles . Positive_regulation PLA2G1B MAP2K6 16098515 1448179 Taken together , our results suggest that PLA2 plays a fundamental role in agonist stimulated exocytosis and that are *involved* in [PLA2] regulation during this process . Positive_regulation PLA2G1B PLAU 16926552 1615039 *stimulated* phosphorylation of cytosolic [PLA2] . Positive_regulation PLA2G1B PTGIS 2124458 145380 Indapamide ( 3 mg/kg i.p. ) induces significant decrease on BP over 60 min. Mepacrine ( 5 mg/kg i.p. ) , [phospholipase A2] *inhibitor* , indomethacin ( 5 mg/kg i.p ) , cyclo-oxygenase inhibitor , and tranylcypromine ( 0,1 mg/kg i.p. ) , inhibitor , antagonize the antihypertensive action of indapamide . Positive_regulation PLA2G1B TGM2 12511595 1038860 Subsequent research showed that [PLA(2)] is *activated* by . Positive_regulation PLA2G1B TGM2 16399636 1513066 Effects of antiflammins on transglutaminase and [phospholipase A2] *activation* by . Positive_regulation PLA2G1B TGM2 20052409 2193615 In vitro studies using recombinant human enzymes reveal that *augments* the enzymatic activity of secreted [phospholipase A(2)] ( PLA(2) ) group X ( sPLA(2)-X ) , an enzyme recently implicated in asthma pathogenesis . Positive_regulation PLA2G1B TGM2 8096844 214585 To our knowledge , this is the first demonstration that catalyzes the incorporation of amines into a phospholipase , and that this post-translational modification *increases* [phospholipase A2] activity . Positive_regulation PLA2G1B TNF 11120795 758218 Although a significant inhibitory effect of MAFP on both *induced* AA release and [PLA(2)] activity in MCF7 was observed , BEL had no effect . Positive_regulation PLA2G1B TNF 11445585 860029 Atypical lambda/iota PKC conveys 5-lipoxygenase/leukotriene B4-mediated cross-talk between [phospholipase A2s] regulating NF-kappa B activation in *response* to and interleukin-1beta . Positive_regulation PLA2G1B TNF 1445362 205199 An augmentation of the amount of released arachidonic acid or the reduction of the *stimulated* [phospholipase A2] activity did not modify the TNF induced DNA fragmentation in the endothelial cells . Positive_regulation PLA2G1B TNF 1500203 193659 Since both interleukin 1 and *induce* expression of the proinflammatory enzyme [phospholipase A2 (PLA2)] , we examined serum PLA2 levels in 14 adults with malaria . Positive_regulation PLA2G1B TNF 16249288 1508392 and leptin both *induced* a time dependent activation of [PLA2G2] and PLA2G5 in placental cells . Positive_regulation PLA2G1B TNF 1643102 194849 Glucocorticoids only moderately reduced PLA2 activity in control cells , but completely inhibited the *induced* increase in the activity of the high-molecular-weight cytosolic [PLA2] . Positive_regulation PLA2G1B TNF 1698425 141450 Previous work suggested that *induces* M-CSF gene expression through activation of [phospholipase A2] and eicosanoid production . Positive_regulation PLA2G1B TNF 1698425 141452 The present studies also demonstrate that *stimulated* [phospholipase A2] activity . Positive_regulation PLA2G1B TNF 1730604 181286 In this report we have examined the ability of to *induce* the activity of [phospholipase A2 (PLA2)] in the cell line C3HA , a murine 3T3-like cell line which is normally resistant to TNF induced cytolysis but can be sensitized with inhibitors of transcription and translation . Positive_regulation PLA2G1B TNF 1730604 181287 Our results show that is normally unable to *induce* the activity of [PLA2] in this cell , as measured by the release of [ 3H ] arachidonic acid . Positive_regulation PLA2G1B TNF 1730604 181288 We find , however , that in the presence of either actinomycin D ( Act D ) or cycloheximide ( CHI ) , TNF is indeed able to induce phospholipase activity and that the *induced* activation of [PLA2] occurs 2-4 h before the onset of 51Cr release . Positive_regulation PLA2G1B TNF 1730604 181290 The ability of to *induce* the activity of [PLA2] was also tested in two other cell types which are resistant to TNF except in the presence of Act D or CHI : SK-MEL-28 , a human melanoma derived cell line , and pVBETK-1cl15.2 , an SV40 transformed murine L cell line . Positive_regulation PLA2G1B TNF 1730604 181291 Our results were the same , treatment with a combination of Act D and or CHI and TNF was *required* to cause activation of [PLA2] . Positive_regulation PLA2G1B TNF 1737348 181913 The analysis of TNF alpha-sensitive cells has shown that [phospholipase A2] is *activated* by in these cells and that the activity of phospholipase A2 is required for their cytolysis . Positive_regulation PLA2G1B TNF 1737348 181914 The measurement of the release of radiolabeled material from cervical and ovarian carcinoma cell lines prelabeled with [ 3H ] arachidonic acid showed that not only was [phospholipase A2] required for the cytolysis of these cells by TNF alpha in the presence of protein synthesis inhibitors , but more importantly , phospholipase A2 was not *activated* by unless protein synthesis was inhibited . Positive_regulation PLA2G1B TNF 1737348 181916 These results indicate that a protein synthesis dependent resistance mechanism expressed by these cell lines blocks TNF alpha mediated cytolysis by preventing the *activation* of [phospholipase A2] by . Positive_regulation PLA2G1B TNF 1846528 151691 We have previously shown that recombinant interleukin 1 (IL-1) and recombinant synergistically *stimulate* [phospholipase A2] release from mesangial cells . Positive_regulation PLA2G1B TNF 1846528 151694 The protein kinase inhibitors H-8 , staurosporine , K252a and amiloride inhibited IL-1 beta- and *stimulated* [phospholipase A2] secretion . Positive_regulation PLA2G1B TNF 1846897 153391 We investigated these possibilities in TNF-alpha priming of PMN and report that *had* no direct effect on [PLA2] activation or metabolite formation . Positive_regulation PLA2G1B TNF 18475466 209533 To our knowledge , this is the first time that an association between intravenous administration and *induction* of circulating [PLA(2)] in man has been established . Positive_regulation PLA2G1B TNF 1885215 165703 Both IL-1 and *induced* the de novo synthesis of [PLA2] in a concentration dependent manner . Positive_regulation PLA2G1B TNF 1989605 152316 Interleukin-1 beta , and forskolin *stimulate* the synthesis and secretion of group II [phospholipase A2] in rat mesangial cells . Positive_regulation PLA2G1B TNF 2033082 159617 Agents which increase intracellular cAMP concentration did not stimulate PLA2-II expression by themselves but selectively enhanced *induced* [PLA2-II] expression about 5-fold . Positive_regulation PLA2G1B TNF 20739059 2324348 In macrophages , the proinflammatory cytokine *increased* the apoptosis rate , the reactive oxygen species production and the activation of c-Jun N-terminal kinase elicited by ferucarbotran , which might be mediated by the induction of cytoplasmic [phospholipase A2] by TNF-a . Positive_regulation PLA2G1B TNF 2121330 143520 Taken together , these findings indicated that *stimulates* [phospholipase A2] and arachidonic acid metabolism in HL-60 cells . Positive_regulation PLA2G1B TNF 2156930 129525 Taken together , these results suggest that LPS *induces* gene expression through activation of [phospholipase A2] and that the level of this induction is regulated by activity of the 5-lipoxygenase and cyclooxygenase pathways . Positive_regulation PLA2G1B TNF 2157420 131451 PMA , FMP , LPS and can *activate* [phospholipase A2] and induce the release of AA from the cell membrane lipid pool . Positive_regulation PLA2G1B TNF 22031851 2547577 Studies in mesangial cells and macrophages were carried out to establish that the in vivo increase in [PLA(2)] and COX were *mediated* by and IL-1ß and that curcumin , by antagonizing the cytokines , could significantly reduce both PLA(2) and COX . Positive_regulation PLA2G1B TNF 2373711 138412 Both forskolin induced and *induced* [PLA2] release responses were almost completely blocked by 10 and 100 nM dexamethasone , respectively , as assayed by protein blotting and PLA2 activity assays . Positive_regulation PLA2G1B TNF 2373711 138414 Inhibition of *induced* [PLA2] release by glucocorticoids may be explained by the blocking of post-transcriptional synthesis of the group II PLA2 . Positive_regulation PLA2G1B TNF 2784674 109032 Interleukin 1 and synergistically *stimulate* prostaglandin synthesis and [phospholipase A2] release from rat renal mesangial cells . Positive_regulation PLA2G1B TNF 3128274 91756 Tumour necrosis factor ( ) *induces* [phospholipase A2] activity and synthesis of a phospholipase A2-activating protein in endothelial cells . Positive_regulation PLA2G1B TNF 3323504 82882 In contrast to IL-1 , neither IL-2 nor *activated* [PLA2] , PGE2 , or neutral protease secretion in these cells and neither of these cytokines inhibited the chondrocyte metabolic response to IL-1 . Positive_regulation PLA2G1B TNF 7556640 327707 The cellular resistance correlated with the inhibition of *induced* activation of [phospholipase A2] and down-modulation of TNF receptors . Positive_regulation PLA2G1B TNF 7853352 286928 Recombinant murine ( 0.1 microgram/mL ) *caused* a dose dependent increase in [PLA2] activity in cultured mouse hepatocytes . Positive_regulation PLA2G1B TNF 7853352 286930 Putative PLA2 inhibitors , chlorpromazine (CPZ) and 4-bromophenacyl bromide ( BPB ) , both prevented the *induced* increase in [PLA2] activity . Positive_regulation PLA2G1B TNF 7853352 286932 Taken together , these results demonstrate that *activates* [PLA2] , which occurs prior to other deleterious events in hepatocytes , and that inhibition of PLA2 activity reduces cell injury by TNF alpha . Positive_regulation PLA2G1B TNF 7853352 286933 Additionally , protein synthesis inhibition potentiates *induction* of [PLA2] and toxicity , suggesting that there is a protein-synthesis dependent protective mechanism in hepatocytes which ameliorates the effects induced by PLA2 . Positive_regulation PLA2G1B TNF 7962141 279308 [Phospholipase A2] *activation* by has been shown to be important in the transduction of signals leading to cell death . Positive_regulation PLA2G1B TNF 8376787 229968 *induced* activation of [phospholipase A2] and release of arachidonic acid metabolites was observed only in the H-2Kb transfected , but not in BL6-8 melanoma cells transfected with neor or class II H-21Ak genes . Positive_regulation PLA2G1B TNF 8409402 233340 Overexpression of major heat shock protein hsp70 inhibits *induced* activation of [phospholipase A2] . Positive_regulation PLA2G1B TNF 8488366 219202 b ) may *stimulate* [phospholipase A2-dependent] AA release without affecting the formation of PAF-acether and c ) pretreatment with TNF-alpha potentiates the formation of PGE2 after stimulation with phospholipase A2 activators . Positive_regulation PLA2G1B TNF 8506288 221440 Cytoplasmic [phospholipase A2] activity and gene expression are *stimulated* by : dexamethasone blocks the induced synthesis . Positive_regulation PLA2G1B TNF 8554585 340042 [Phospholipase A2] is *activated* by in primary hepatocytes stimulated by a deleted form of hepatocyte growth factor . Positive_regulation PLA2G1B TNF 8554585 340043 *activated* [PLA2] in hepatocytes and it is believed that the subsequent production of PGE2 plays a role in the `` priming '' process in these cells and at the same time amplifies the proliferating signals induced by hepatocyte-specific growth factors . Positive_regulation PLA2G1B TNF 8557994 348688 Overexpression of A20 also inhibits *induced* activation of [phospholipase A2] in a similar dose dependent manner as it inhibits TNF mediated apoptosis , whereas it does not affect the activation of phospholipase A2 by anti-Fas . Positive_regulation PLA2G1B TNF 8611631 352992 In vitro activity assay revealed that *increased* the dithiothreitol ( DTT ) -resistant [PLA2] activity which was blocked by the cPLA2 inhibitor AACOCF3 . Positive_regulation PLA2G1B TNF 8654401 358799 Northern blot analysis showed that and IL-1beta *increased* both [PLA2] and inducible cyclooxygenase ( Cox-2 ) mRNA transcription . Positive_regulation PLA2G1B TNF 8704250 373389 We conclude that *Induced* stimulation of coagulation , fibrinolysis , neutrophil degranulation , and release of secretory [phospholipase A2] are predominantly mediated by the p55 TNF receptor . Positive_regulation PLA2G1B TNF 8746487 343491 The results suggest that and IL-6 *stimulate* the production of type II [PLA2] in the plasma of patients with sepsis . Positive_regulation PLA2G1B TNF 9042153 416055 Because along with IL-1 beta markedly *enhance* the gene expression and extracellular release of proinflammatory secretory nonpancreatic [phospholipase A2] ( sPLA2 ) , we tested the impact of MTD on the expression of sPLA2 . Positive_regulation PLA2G1B TNF 9405367 469776 In association with cell death , c-Myc impaired *induced* activation of [phospholipase A2] , JNK protein kinase and cell survival-signaling associated NF-kappaB transcription factor complex . Positive_regulation PLA2G1B TNF 9746498 533320 and IL-1beta together *enhanced* synergistically cytosolic and membrane [PLA2] activities and arachidonic acid release that were blocked differentially by MAFP and BEL , respectively , and inhibited completely by MAFP plus BEL . Positive_regulation PLA2G2A GIF 15863363 1401266 The present study shows that the incubation of human aortic smooth muscle cells ( HASMC ) and HepG2 cells with atorvastatin and mevastatin as HMG-CoA reductase inhibitors potentiated the *induced* [group IIA phospholipase A(2)] ( sPLA ( 2 ) -IIA ) expression in a dose- and time dependent manner . Positive_regulation PLA2G2A GSK3B 15527765 1332454 negatively *regulates* [group IIA phospholipase A2] expression in human aortic smooth muscle and HepG2 hepatoma cells . Positive_regulation PLA2G2A IFNG 10811652 714640 *induces* secretory [group IIA phospholipase A2] in human arterial smooth muscle cells . Positive_regulation PLA2G2A IFNG 15863363 1401265 Statins potentiate the induced *upregulation* of [group IIA phospholipase A2] in human aortic smooth muscle cells and HepG2 hepatoma cells . Positive_regulation PLA2G2A IL1A 11156559 780608 2. In this study we investigated the effects of ATP and UTP on *induced* mRNA expression and activity of [group IIA phospholipase A(2)] ( sPLA ( 2 ) -IIA ) in rat mesangial cells . Positive_regulation PLA2G2A IL1B 11571275 875436 [Group IIa phospholipase A(2)] ( GIIa PLA(2) ) is released by some cells in *response* to . Positive_regulation PLA2G2A MAPK1 11571275 875410 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Positive_regulation PLA2G2A MAPK10 11571275 875411 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Positive_regulation PLA2G2A MAPK11 11571275 875412 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Positive_regulation PLA2G2A MAPK12 11571275 875413 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Positive_regulation PLA2G2A MAPK13 11571275 875414 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Positive_regulation PLA2G2A MAPK14 11571275 875415 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Positive_regulation PLA2G2A MAPK15 11571275 875409 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Positive_regulation PLA2G2A MAPK3 11571275 875416 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Positive_regulation PLA2G2A MAPK4 11571275 875417 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Positive_regulation PLA2G2A MAPK6 11571275 875418 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Positive_regulation PLA2G2A MAPK7 11571275 875419 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Positive_regulation PLA2G2A MAPK8 11571275 875420 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Positive_regulation PLA2G2A MAPK9 11571275 875421 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Positive_regulation PLA2G2A TNF 11856764 914388 Potentiation of *stimulated* [group IIA phospholipase A(2)] expression by peroxisome proliferator activated receptor alpha activators in rat mesangial cells . Positive_regulation PLA2G2D TNF 15611272 1357377 Both [sPLA(2)s] *induced* and IL-6 release in a concentration dependent manner by increasing their mRNA expression . Positive_regulation PLA2G4A EPHB2 10897414 711858 Activation of [cytosolic phospholipase A2] by opsonized zymosan in human neutrophils *requires* both and p38 MAP-kinase . Positive_regulation PLA2G4A EPHB2 10996851 733923 This implies that intracellular Ca ( 2+ ) level is the key factor for induction of cPLA(2) activity and thapsigargin elicited activation itself is substantially *sufficient* for [cPLA(2)] activation upon intracellular Ca ( 2+ ) increase . Positive_regulation PLA2G4A EPHB2 11279537 764691 *dependent* [cytosolic phospholipase A2] activity is induced by CD95 ligand cross linking in the mouse derived Sertoli cell line TM4 and is required to trigger apoptosis in CD95 bearing cells . Positive_regulation PLA2G4A EPHB2 12423237 1014041 However , complete inhibition of by U0126 , an inhibitor of mitogen activated protein kinase kinase ( MEK ) , did not completely *inhibit* PMA stimulated [cPLA2] and AA release . Positive_regulation PLA2G4A EPHB2 15894894 1407903 These results suggest that either or p38 MAP-kinase are involved in the activation of both cPLA2 and NADPH oxidase , and that [cPLA2] is *required* for activation of the NADPH oxidase by Ang II in human neutrophils . Positive_regulation PLA2G4A EPHB2 16754300 1571457 Our findings are the first to demonstrate that the detrimental consequences of H. pylori LPS on gastric mucin synthesis involve *dependent* [cPLA2] activation that leads to up-regulation in PAF generation and ET-1 production . Positive_regulation PLA2G4A EPHB2 16983494 1617451 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary mucin synthesis involves *dependent* [cPLA2] activation that leads to up-regulation in PAF production and ET-1 generation . Positive_regulation PLA2G4A EPHB2 17440231 1729600 The results of our findings point to H. pylori LPS induced *dependent* [cPLA(2)] activation as a critical factor influencing the level of PAF generation , and hence the extent of pathological consequences of H. pylori infection on the synthesis of gastric mucin . Positive_regulation PLA2G4A EPHB2 18622138 1984350 Either p38 or an inhibitor significantly *attenuated* not only [cPLA(2)] phosphorylation and activity , but also the late-phase anaphylaxis . Positive_regulation PLA2G4A EPHB2 18622138 1984366 TNF-alpha-induces [cPLA(2)] activation through the pathway *involving* p38 MAPK and activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Positive_regulation PLA2G4A EPHB2 23563696 2794530 Induction in gastric mucosal prostaglandin and nitric oxide by Helicobacter pylori is dependent on mediated *activation* of IKK-ß and [cPLA2] : modulatory effect of ghrelin . Positive_regulation PLA2G4A EPHB2 23563696 2794543 We show that activation by the LPS *leads* to phosphorylation of the inhibitory ?B kinase-ß ( IKK-ß ) and [cytosolic phospholipase A2 (cPLA2)] , and is reflected in the upsurge in NF-?B nuclear translocation , induction in COX-2 and iNOS expression , and up-regulation in cPLA2 activity . Positive_regulation PLA2G4A F2R 7782348 309652 Differential *activation* of [cytosolic phospholipase A2 (cPLA2)] by thrombin and agonist peptide in human platelets . Positive_regulation PLA2G4A FAS 9311830 455083 Moreover , the mechanism of action of BHRF1 resembled that of Bcl-2 and Bcl-xL as it inhibited TNF- and induced *activation* of two enzymes participating in the apoptosis pathway , [cytosolic phospholipase A2] and caspase-3/CPP32 , but did not interfere with the activation of NF-kappaB-like transcription factors . Positive_regulation PLA2G4A IL1B 10807497 692220 Augmented PGE2 production by mineralizing osteoblasts after IL-1beta treatment , and the involvement of *induced* [cPLA2] , sPLA2 , COX-2 and PGE synthase activities in this phenomenon were demonstrated . Positive_regulation PLA2G4A IL1B 11407686 825870 significantly *up-regulated* PLA2 activity ( P < 0.005 ) and [cPLA2] mRNA expression while anti-MIF monoclonal antibody ( mAb ) significantly inhibited this IL-1beta induced PLA2 activity ( P < 0.02 ) . Positive_regulation PLA2G4A IL1B 11445585 860048 In this study , we have further investigated the mechanisms of PLA(2) modulated NF-kappaB activation with respect to specific kinases involved in *stimulated* [cPLA(2)] phosphorylation and NF-kappaB activation . Positive_regulation PLA2G4A IL1B 11445585 860054 The protein kinase C ( PKC ) inhibitors RO 31-8220 , Gö 6976 , and a pseudosubstrate peptide inhibitor of atypical PKCs attenuated arachidonic acid release , [cPLA(2)] phosphorylation , and NF-kappaB activation *induced* by TNF-alpha or , thus indicating atypical PKCs in cPLA(2) regulation and transcription factor activation . Positive_regulation PLA2G4A IL1B 11445585 860058 Transfection of a kinase-inactive mutant of lambda/iotaPKC in NIH-3T3 fibroblasts completely abolished *stimulated* cellular arachidonic acid release and [cPLA(2)] activation assayed in vitro , confirming the role of lambda/iotaPKC in cPLA(2) regulation . Positive_regulation PLA2G4A IL1B 11445585 860072 Hence , lambda/iotaPKC regulates snpPLA ( 2 ) /LTB ( 4 ) -mediated [cPLA(2)] activation , cellular arachidonic acid release , and NF-kappaB activation *induced* by TNF-alpha and . Positive_regulation PLA2G4A IL1B 11863390 917487 We have shown that *induces* the in vitro expression of genes believed to play important role in ovulation ( IL-1 beta itself , its receptors , IL-1 beta receptor antagonist , glucose transporters 1 and 3 , secretory and [cytosolic phospholipase A(2)] , prostaglandin endoperoxide synthase 1 and 2 ) . Positive_regulation PLA2G4A IL1B 15205451 1295587 IL-1beta significantly increased the phosphorylation of extracellular signal regulated kinase 1 ( ERK1 ) /ERK2 MAPKs and cPLA(2) and *induced* [cPLA(2)] phosphorylation was blocked by PD98059 . Positive_regulation PLA2G4A IL1B 15883739 1406647 None of the PG metabolites tested showed significant effects on the level of COX-1 or cPLA2 protein expression , except for PGF2alpha , which increased *induced* [cPLA2] protein expression slightly . Positive_regulation PLA2G4A IL1B 15950779 1421565 We report that *induced* [cPLA2] and COX-2 mRNA and protein expression and subsequent prostaglandin E2 ( PGE2 ) release in a time dependent manner in H4 neuroglioma cells . Positive_regulation PLA2G4A IL1B 15950779 1421566 *induced* [cPLA2] and COX-2 gene expression is modulated through the p38 MAPK pathway in both neuroglioma and neuroblastoma cells . Positive_regulation PLA2G4A IL1B 16338461 1503944 Dexamethasone fails to inhibit the *induction* of [cytosolic phospholipase A(2)] expression by in cultured primary human amnion fibroblasts . Positive_regulation PLA2G4A IL1B 16645161 1604685 significantly *increased* the phosphorylation of p38 MAPK and [cPLA(2)] . Positive_regulation PLA2G4A IL1B 16645161 1604686 *induced* [cPLA(2)] phosphorylation was blocked by SB-203580 but not by AACOCF3 , suggesting sequential activation of p38 MAPK phosphorylating cPLA(2) . Positive_regulation PLA2G4A IL1B 16935997 1615359 In primary cultures of uterine myocytes , [cPLA(2)] mRNA expression was *increased* by and IL-6 ; Positive_regulation PLA2G4A IL1B 17046175 1674722 We found that *increased* the expression levels of [cPLA(2)] and COX-2 , and also increased the secretion of PGE ( 2 ) . Positive_regulation PLA2G4A IL1B 18708082 1974577 Involvement of MAPKs , NF-kappaB and p300 co-activator in *induced* [cytosolic phospholipase A2] expression in canine tracheal smooth muscle cells . Positive_regulation PLA2G4A IL1B 18708082 1974580 However , the mechanisms underlying *induced* [cPLA2] expression and PGE2 synthesis by canine tracheal smooth muscle cells ( CTSMCs ) have not been defined . Positive_regulation PLA2G4A IL1B 18708082 1974581 Furthermore , *induced* [cPLA2] expression and PGE2 synthesis was inhibited by a selective NF-kappaB inhibitor ( helenalin ) or transfection with dominant negative mutants of NF-kappaB inducing kinase (NIK) , IkappaB kinase (IKK)-alpha , and IKK-beta . Positive_regulation PLA2G4A IL1B 18708082 1974587 *induced* [cPLA2] expression and PGE2 production was inhibited by actinomycin D and cycloheximide , indicating the involvement of transcriptional and translational events in these responses . Positive_regulation PLA2G4A IL1B 18708082 1974588 These results suggest that in CTSMCs , *induced* [cPLA2] expression and PGE2 synthesis was independently mediated through activation of MAPKs and NF-kappaB pathways and was connected to p300 recruitment and activation . Positive_regulation PLA2G4A IL1B 19918789 2209946 Our results showed that PA (1) inhibited anchorage dependent and -independent A549 growth in a concentration dependent manner , ( 2 ) induced apoptosis and disrupted mitochondrial membrane potential in A549 cells , and at nonlethal levels , ( 3 ) decreased *induced* activation of [cPLA(2)] and COX-2 , ( 4 ) suppressed IL-1 beta induced activation of mitogen activated protein kinases ( MAPKs ) , and ( 5 ) inhibited IL-1 beta stimulated nuclear factor kappa B (NF-kappaB) signaling pathways . Positive_regulation PLA2G4A IL1B 20069553 2225541 However , the mechanisms underlying *induced* [cPLA(2)] expression and PGE ( 2 ) synthesis in human tracheal smooth muscle cells ( HTSMCs ) remain unknown . Positive_regulation PLA2G4A IL1B 20069553 2225546 *induced* [cPLA(2)] expression was also inhibited by pretreatment with a NF-kappaB inhibitor , helenalin or transfection with siRNA of NIK , IKKalpha , or IKKbeta . Positive_regulation PLA2G4A IL1B 20069553 2225547 In addition , transfection with p300 siRNA blocked [cPLA(2)] expression *induced* by . Positive_regulation PLA2G4A IL1B 20069553 2225548 These results suggest that in HTSMCs , activation of MAPKs , NF-kappaB , and p300 are essential for *induced* [cPLA(2)] expression and PGE ( 2 ) secretion . Positive_regulation PLA2G4A IL1B 7480804 326818 *induces* the synthesis and activity of [cytosolic phospholipase A2] and the release of prostaglandin E2 in human amnion derived WISH cells . Positive_regulation PLA2G4A IL1B 7480804 326819 The objective of this study was to examine the expression and activity of [cytosolic phospholipase A2 (cPLA2)] in relation to prostaglandin E2 ( PGE2 ) synthesis in human amnion derived WISH cells in *response* to stimulation by . Positive_regulation PLA2G4A IL1B 7480804 326822 The parallel increase in total cellular cPLA2 activity and cPLA2 protein level indicates that may *induce* the synthesis of [cPLA2] . Positive_regulation PLA2G4A IL1B 8224206 234764 *induced* [cytosolic phospholipase A2] activity and protein synthesis is blocked by dexamethasone in rat mesangial cells . Positive_regulation PLA2G4A IL1B 8224206 234768 In parallel with the effect of dexamethasone on the sPLA2 , this glucocorticoid inhibits the IL-1 beta enhanced [cPLA2] activity as a *result* of the suppression of induced cPLA2 gene expression . Positive_regulation PLA2G4A IL1B 8711133 371295 *Induction* of both [cytosolic phospholipase A2] and prostaglandin H synthase-2 by in WISH cells in inhibited by dexamethasone . Positive_regulation PLA2G4A IL1B 8711133 371296 In previous studies we have shown that *induced* both PGE2 release and total cellular [cPLA2] activity and cPLA2 protein synthesis in human amnion derived WISH cells . Positive_regulation PLA2G4A IL1B 8711133 371299 Using RT-PCR , we found that ( 0.1 ng/ml ) coordinately *induced* both [cPLA2] and PGHS-2 mRNA expression within 2 hours . Positive_regulation PLA2G4A IL1B 8711133 371301 The synthetic glucocorticoid dexamethasone ( 10 ( -10 ) -10 ( -6 ) M ) inhibited *induced* [cPLA2] and PGHS-2 mRNA expression activity and protein synthesis and PGE2 release in a concentration dependent manner . Positive_regulation PLA2G4A IL1B 8711133 371303 In addition , cycloheximide ( 5 micrograms/ml ) apparently superinduced , but actinomycin D ( 2 micrograms/ml ) inhibited *induced* [cPLA2] and PGHS-2 mRNA expression suggesting that both are immediate early genes and a transcriptional mechanism is involved in the induction of both cPLA2 and PGHS-2 mRNA by IL-1 beta . Positive_regulation PLA2G4A IL1B 9060638 417788 Ad infection did not inhibit [cPLA2] translocation in *response* to or platelet derived growth factor . Positive_regulation PLA2G4A MAP2K6 11546664 856613 The mitogen activated protein kinase (MAPK) kinase ( ) inhibitors , PD-98059 and U-0126 , blocked IL-1 alpha induced ERK activation and partially *attenuated* [cPLA(2)alpha] phosphorylation and PGI ( 2 ) release , suggesting that ERK dependent and -independent pathways regulate cPLA(2)alpha phosphorylation . Positive_regulation PLA2G4A S1PR3 18502815 1939394 [Cytosolic phospholipase A2alpha] activation induced by S1P is *mediated* by the receptor in lung epithelial cells . Positive_regulation PLA2G4A TNF 10329351 613157 also *increased* the level of immunoreactive [cPLA2] protein in a time dependent manner with the highest levels evident after 8 and 16 h . Positive_regulation PLA2G4A TNF 10749570 681180 Alveolar increased [ Ca ( 2+ ) ] ( i ) and *activated* [cPLA(2)] in alveolar epithelial cells , and increased both endothelial [ Ca ( 2+ ) ] ( i ) and P-selectin expression in adjoining perialveolar capillaries . Positive_regulation PLA2G4A TNF 10913368 716283 *Activation* of ERK1/2 and [cPLA(2)] by the p55 receptor occurs independently of FAN . Positive_regulation PLA2G4A TNF 10913368 716289 Analysis of embryonal fibroblasts from FAN knockout mice revealed that induced *activation* of both ERK and [cPLA(2)] occurs without involvement of FAN . Positive_regulation PLA2G4A TNF 10913368 716291 Furthermore , we provide evidence that the dependent *activation* of ERK and [cPLA(2)] requires the intact death domain of TNF-R55 . Positive_regulation PLA2G4A TNF 10913368 716294 Finally , we demonstrate that in murine fibroblasts cPLA(2) is phosphorylated in *response* to solely by ERK , but not by p38 mitogen activated protein kinase , suggesting a signaling pathway from TNF-R55 via the death domain to ERK and [cPLA(2)] . Positive_regulation PLA2G4A TNF 10930295 719778 IL-1beta , PMA and *increased* both [cPLA(2)enzyme] activity and expression , but did not lead to any increase in npPLA ( 2 ) expression or activity . Positive_regulation PLA2G4A TNF 11120795 758220 Western blot analysis revealed that *induced* a differential cleavage of [cPLA(2)] in TNF-sensitive vs TNF-resistant cells . Positive_regulation PLA2G4A TNF 11122142 762718 In this study , we found that Dex inhibited both spontaneous and *induced* activation of [cPLA(2)] . Positive_regulation PLA2G4A TNF 11266661 797177 However , *caused* no activation of p42/p44 MAPK or [cytosolic phospholipase A(2)] activity . Positive_regulation PLA2G4A TNF 11404253 825255 We found that in H441 cells , as reported in other cell types , [cytosolic phospholipase A2 (cPLA2)] is *activated* by . Positive_regulation PLA2G4A TNF 11445585 860047 In this study , we have further investigated the mechanisms of PLA(2) modulated NF-kappaB activation with respect to specific kinases involved in *stimulated* [cPLA(2)] phosphorylation and NF-kappaB activation . Positive_regulation PLA2G4A TNF 11445585 860053 The protein kinase C ( PKC ) inhibitors RO 31-8220 , Gö 6976 , and a pseudosubstrate peptide inhibitor of atypical PKCs attenuated arachidonic acid release , [cPLA(2)] phosphorylation , and NF-kappaB activation *induced* by or IL-1beta , thus indicating atypical PKCs in cPLA(2) regulation and transcription factor activation . Positive_regulation PLA2G4A TNF 11445585 860057 Transfection of a kinase-inactive mutant of lambda/iotaPKC in NIH-3T3 fibroblasts completely abolished *stimulated* cellular arachidonic acid release and [cPLA(2)] activation assayed in vitro , confirming the role of lambda/iotaPKC in cPLA(2) regulation . Positive_regulation PLA2G4A TNF 11445585 860071 Hence , lambda/iotaPKC regulates snpPLA ( 2 ) /LTB ( 4 ) -mediated [cPLA(2)] activation , cellular arachidonic acid release , and NF-kappaB activation *induced* by and IL-1beta . Positive_regulation PLA2G4A TNF 12401196 1009270 Role of caspases in *mediated* regulation of [cPLA(2)] . Positive_regulation PLA2G4A TNF 15950244 1445959 On the other hand , NDGA did not interfere with the *induced* phosphorylation of [cPLA(2)] , indicating that NDGA does not block all TNF dependent signaling . Positive_regulation PLA2G4A TNF 1643102 194847 Glucocorticoids inhibit *induced* [cytosolic phospholipase A2] activity . Positive_regulation PLA2G4A TNF 19415240 2089856 Furthermore , OGD and the NF-kappaB activator *stimulated* the expression of [cPLA-2] , cyclooxygenase-2 (COX-2) , and mPGES-1 and increased the release of PGE ( 2 ) from neurons . Positive_regulation PLA2G4A TNF 21068383 2376496 Selective cytosolic phospholipase A(2)-a ( cPLA(2)-a ) inhibitors abrogate TNF/sPLA ( 2 ) -IIA mediated PGE ( 2 ) production without affecting COX-2 levels , indicating arachidonic acid ( AA ) flux to COX-2 occurs exclusively through *mediated* activation of [cPLA(2)-a] . Positive_regulation PLA2G4A TNF 21199900 2379096 Preincubation of endothelial ECV-304 cells that express ICAM-1 and of HUVEC that express ICAM-1 and VCAM-1 with 1 µM AS prevented [cPLA(2)a] and the adhesion molecule upregulation *induced* by and inhibited their adherence to phagocyte like-PLB cells . Positive_regulation PLA2G4A TNF 21520062 2423113 Activation and *induction* of [cytosolic phospholipase A2] by mediated through Nox2 , MAPKs , NF-?B , and p300 in human tracheal smooth muscle cells . Positive_regulation PLA2G4A TNF 21520062 2423114 However , the mechanisms underlying *induced* [cPLA(2)] expression and PGE ( 2 ) synthesis in human tracheal smooth muscle cells ( HTSMCs ) remain unknown . Positive_regulation PLA2G4A TNF 21520062 2423129 *induced* [cPLA(2)] expression was also inhibited by pretreatment with a selective NF-?B inhibitor [ helenalin ( HLN ) ] or transfection with dominant negative mutants of NF-?B inducing kinase ( NIK ) or I?B kinase ( IKK ) a/ß. TNF-a induced NF-?B translocation was blocked by pretreatment with NAC , DPI , APO , or HLN , but not by U0126 , SB202190 , or SP600125 . Positive_regulation PLA2G4A TNF 21520062 2423130 These results suggested that in HTSMCs , activation of p47(phox) , MAPKs , NF-?B , and p300 is essential for *induced* [cPLA(2)] expression and PGE ( 2 ) release . Positive_regulation PLA2G4A TNF 22427514 2594380 H/R and *induced* [cPLA(2)a] phosphorylation in cPLA(2)a ( +/+ ) cardiomyocytes , which was reversible by sTNFR : Fc . Positive_regulation PLA2G4A TNF 24069158 2846986 *induces* [cytosolic phospholipase A2] expression in human lung epithelial cells via JNK1/2- and p38 MAPK dependent AP-1 activation . Positive_regulation PLA2G4A TNF 24069158 2846987 However , the mechanisms underlying *induced* [cPLA2] expression in human lung epithelial cells ( HPAEpiCs ) were not completely understood . Positive_regulation PLA2G4A TNF 24069158 2847003 Furthermore , *induced* [cPLA2] promoter activity was abrogated by transfection with the point mutated AP-1 cPLA2 construct . Positive_regulation PLA2G4A TNF 24069158 2847010 In an in vivo study , we found that *induced* leukocyte count in BAL fluid of mice and [cPLA2] mRNA levels in lung tissues via MAPKs and AP-1 . Positive_regulation PLA2G4A TNF 24069158 2847067 Taken together , these results demonstrated that *induced* [cPLA2] expression was mediated through p38 MAPK- and JNK1/2 dependent p300/c-Fos/c-Jun/ATF2 complex formation in HPAEpiCs . Positive_regulation PLA2G4A TNF 24441870 2922918 *induces* [cytosolic phospholipase A2] expression via Jak2/PDGFR dependent Elk-1/p300 activation in human lung epithelial cells . Positive_regulation PLA2G4A TNF 24441870 2922921 However , the mechanisms underlying *induced* [cPLA2] expression in human lung epithelial cells ( HPAEpiCs ) were not completely understood . Positive_regulation PLA2G4A TNF 24441870 2922999 Taken together , these results demonstrated that *induced* [cPLA2] expression and PGE2 release were mediated through a Jak2/PDGFR/PI3K/Akt/p42/p44 MAPK/Elk-1 pathway in HPAEpiCs . Positive_regulation PLA2G4A TNF 24616552 2925419 HO-1 induction by CO-RM2 attenuates *induced* [cytosolic phospholipase A2] expression via inhibition of PKCa dependent NADPH oxidase/ROS and NF-?B . Positive_regulation PLA2G4A TNF 24616552 2925420 The objective of the study was to investigate the detailed mechanisms of *induced* [cPLA2] expression and to determine whether carbon monoxide releasing molecule-2 ( CO-RM2 ) suppresses TNF-a induced expression of NF-?B related proinflammatory genes , including cPLA2 , via HO-1 induction in RA synovial fibroblasts ( RASFs ) . Positive_regulation PLA2G4A TNF 24616552 2925421 Here , we reported that *induced* [cPLA2] expression was mediated through TNFR1/PKCa dependent signaling pathways , including NADPH oxidase (NOX) activation/ROS production and NF-?B activation . Positive_regulation PLA2G4A TNF 24616552 2925422 CO-RM2 significantly suppressed *induced* [cPLA2] expression by inhibiting the ROS generation and the phosphorylation of NF-?B p65 and IKK a/ß , but not the phosphorylation of p38 MAPK and JNK1/2 . Positive_regulation PLA2G4A TNF 7726846 302072 We demonstrate that stimulation of neutrophils *induces* the phosphorylation of [cytosolic phospholipase A2 (cPLA2)] and also increases its activity . Positive_regulation PLA2G4A TNF 7806430 284758 We have observed that pentoxifylline prevents the *mediated* activation of sn-2 arachidonic acid-specific [cytosolic phospholipase A2] , an important component of the signal transduction pathway of TNF alpha cytotoxicity . Positive_regulation PLA2G4A TNF 8506288 221441 By itself , *causes* a modest increase in [cPLA2] activity , but with the Ca2+ ionophore A23187 it provides a strong synergistic action . Positive_regulation PLA2G4A TNF 8611631 352991 *induces* the 85-kDa [cytosolic phospholipase A2] gene expression in human bronchial epithelial cells . Positive_regulation PLA2G4A TNF 8611631 352993 These results demonstrate that the [cPLA2] gene expression is *up-regulated* by and this effect may contribute to the TNF-alpha stimulated AA release in airway epithelial cells . Positive_regulation PLA2G4A TNF 8852946 387881 We conclude that ( 1 ) IL-1 , , and PTH , but not IL-6 nor IL-11 , can *increase* the expression of PGHS-2 , [cPLA2] , and PGE2 production in cultured mouse calvariae ; Positive_regulation PLA2G4A TNF 8870643 389429 Furthermore , the *stimulated* phosphorylation and activation of [cPLA2] are completely abolished in cells treated with SB 203580 . Positive_regulation PLA2G4A TNF 9060638 417769 Adenovirus E3-10.4K/14.5K protein complex inhibits *induced* translocation of [cytosolic phospholipase A2] to membranes . Positive_regulation PLA2G4A TNF 9060638 417781 We now report that *induces* translocation of [cPLA2] from the cytosol to membranes in Ad-infected human A549 cells and that E3-10.4K/14.5K but not E3-14.7K or E1B-19K is required to inhibit TNF induced translocation of cPLA2 . Positive_regulation PLA2G4A TNF 9060638 417785 Under the same conditions , Ad infection did not inhibit *induced* phosphorylation of [cPLA2] or TNF activation of NFkappaB . Positive_regulation PLA2G4A TNF 9060638 417790 We propose that E3-10.4K/14.5K inhibits TNF induced AA release and apoptosis by directly or indirectly inhibiting *induced* translocation of [cPLA2] from the cytosol to membranes . Positive_regulation PLA2G4A TNF 9485014 488201 Both immunofluorescence microscopy and Western blotting of cell subcompartments demonstrated translocation of [cPLA2] from the cytosol to the cell membrane in *response* to . Positive_regulation PLA2G4A TNF 9485014 488203 Prior incubation of cells with 1,25 ( OH ) 2D3 significantly inhibited ( a ) *induced* [ 3H ] arachidonic acid release and apoptosis , ( b ) TNF induced translocation of [cPLA2] to the membrane , and ( c ) the up-regulation of cPLA2 mRNA with TNF . Positive_regulation PLA2G4A TNF 9485014 488204 1,25 ( OH ) 2D3 directly inhibits [cPLA2] translocation and mRNA up-regulation *induced* by . Positive_regulation PLA2G4A TNF 9622592 511265 and growth factors *had* no significant effect on [cPLA2] mRNA expression . Positive_regulation PLA2G4A TNF 9637506 513726 *Activation* of [cytosolic phospholipase A2 (cPLA2)] by has been shown to be an important component of the signaling pathway leading to cell death . Positive_regulation PLA2G4A TNF 9637506 513727 The protein synthesis inhibitor , cycloheximide , increased *induced* [cPLA2] activity and cytotoxicity in both CEM and CEM/VLB100 cell lines . Positive_regulation PLA2G4A TNF 9831076 551405 Moreover , a comparative study using TNF and anti-Fas antibodies as cell death stimuli showed that PLD and [cPLA2] are specifically *activated* by . Positive_regulation PLA2G5 TNF 16249288 1508394 and leptin both *induced* a time dependent activation of PLA2G2 and [PLA2G5] in placental cells . Positive_regulation PLA2G6 ALOX5 17720770 1816970 The low PUFA diet ( % energy , 1.2 % LA+0.06 % ALA ) increased arachidonic acid ( AA ) and decreased eicosapentaenoic acid ( EPA ) in heart membranes and increased Ca ( 2+ ) -independent [iPLA(2)] activity , COX-2 expression , and *activation* of <5-LO> . Positive_regulation PLA2G6 F2R 12372769 996481 Stimulation of with thrombin or PAR-2 by tryptase *leads* to activation of a membrane associated [iPLA(2)] and the production of platelet activating factor , arachidonic acid , and PGE ( 2 ) . Positive_regulation PLA2G6 TNF 9746498 533319 *induced* increases in cytosolic [iPLA2] activity and arachidonic acid release were completely blocked by methyl arachidonyl fluorophosphonate ( MAFP ) but not by bromoenol lactone ( BEL ) . Positive_regulation PLAA IL1B 9227468 443232 *induces* synthesis of [phospholipase A2-activating protein] in rabbit distal colon . Positive_regulation PLAA IL1B 9227468 443235 *caused* a concentration dependent and a time dependent increase in [PLAP] levels as well as in PLA2 activity , with the maximal increase observed at an IL-1 beta concentration between 10 and 30 ng/ml reached in 2-10 min . Positive_regulation PLAA IL1B 9227468 443236 The [PLAP] mRNA levels were also *regulated* by with a similar time course . Positive_regulation PLAA TNF 18291623 1878552 We demonstrated for the first time that the *induction* of native [PLAA] by can perpetuate inflammation by enhancing activation of PLA(2) and NF-kappaB . Positive_regulation PLAA TNF 3128274 91757 Tumour necrosis factor ( ) *induces* phospholipase A2 activity and synthesis of a [phospholipase A2-activating protein] in endothelial cells . Positive_regulation PLAA TNF 7706741 297816 [Phospholipase A2-activating protein] *induces* the synthesis of IL-1 and in human monocytes . Positive_regulation PLAGL1 ADCYAP1 19346254 2080913 In cerebellar granule cells in culture , an increase in [Lot1] expression was paralleled by inhibition of proliferation and up-regulation of the receptor , which in turn positively *regulated* Lot1 expression . Positive_regulation PLAGL1 JUN 16061485 1460154 Luciferase reporter analysis and mutagenesis of the Lot1 promoter region indicated a crucial *role* of the binding site ( located at -268 bp ) in cAMP induced [Lot1] transcription . Positive_regulation PLAGL1 MAP2K1 10597250 573577 Blocking the ligand activated EGFR signal transduction pathway by the specific EGF receptor inhibitor , tyrphostin AG1478 , and the inhibitor , PD098059 , *restores* the normal level of [Lot1] gene expression . Positive_regulation PLAGL1 MAP2K2 10597250 573578 Blocking the ligand activated EGFR signal transduction pathway by the specific EGF receptor inhibitor , tyrphostin AG1478 , and the inhibitor , PD098059 , *restores* the normal level of [Lot1] gene expression . Positive_regulation PLAGL1 MAP2K3 10597250 573579 Blocking the ligand activated EGFR signal transduction pathway by the specific EGF receptor inhibitor , tyrphostin AG1478 , and the inhibitor , PD098059 , *restores* the normal level of [Lot1] gene expression . Positive_regulation PLAGL1 MAP2K4 10597250 573580 Blocking the ligand activated EGFR signal transduction pathway by the specific EGF receptor inhibitor , tyrphostin AG1478 , and the inhibitor , PD098059 , *restores* the normal level of [Lot1] gene expression . Positive_regulation PLAGL1 MAP2K5 10597250 573581 Blocking the ligand activated EGFR signal transduction pathway by the specific EGF receptor inhibitor , tyrphostin AG1478 , and the inhibitor , PD098059 , *restores* the normal level of [Lot1] gene expression . Positive_regulation PLAGL1 MAP2K6 10597250 573582 Blocking the ligand activated EGFR signal transduction pathway by the specific EGF receptor inhibitor , tyrphostin AG1478 , and the inhibitor , PD098059 , *restores* the normal level of [Lot1] gene expression . Positive_regulation PLAGL1 MAP2K7 10597250 573583 Blocking the ligand activated EGFR signal transduction pathway by the specific EGF receptor inhibitor , tyrphostin AG1478 , and the inhibitor , PD098059 , *restores* the normal level of [Lot1] gene expression . Positive_regulation PLAT A2M 8501135 220936 We have shown ( Bizik et al. , Cell Regul 1 : 895-905 , 1990 ) that [tPA] can activate plasminogen on the surface of human melanoma cells in the *presence* of secretion . Positive_regulation PLAT ACE 12015245 941776 Angiotensin II increases the production and secretion of plasminogen activator inhibitor-1 , while *contributes* to reduced production of [tissue plasminogen activator] and endothelial nitric oxide synthesis by bradykinin degradation . Positive_regulation PLAT ADCY1 21919910 2506834 Pituitary *activating* polypeptide ( PACAP ) and [tissue plasminogen activator (tPA)] play important roles in neuronal migration and survival . Positive_regulation PLAT ADCY10 21919910 2506833 Pituitary *activating* polypeptide ( PACAP ) and [tissue plasminogen activator (tPA)] play important roles in neuronal migration and survival . Positive_regulation PLAT ADCY2 21919910 2506835 Pituitary *activating* polypeptide ( PACAP ) and [tissue plasminogen activator (tPA)] play important roles in neuronal migration and survival . Positive_regulation PLAT ADCY3 21919910 2506836 Pituitary *activating* polypeptide ( PACAP ) and [tissue plasminogen activator (tPA)] play important roles in neuronal migration and survival . Positive_regulation PLAT ADCY4 21919910 2506837 Pituitary *activating* polypeptide ( PACAP ) and [tissue plasminogen activator (tPA)] play important roles in neuronal migration and survival . Positive_regulation PLAT ADCY5 21919910 2506838 Pituitary *activating* polypeptide ( PACAP ) and [tissue plasminogen activator (tPA)] play important roles in neuronal migration and survival . Positive_regulation PLAT ADCY6 21919910 2506839 Pituitary *activating* polypeptide ( PACAP ) and [tissue plasminogen activator (tPA)] play important roles in neuronal migration and survival . Positive_regulation PLAT ADCY7 21919910 2506840 Pituitary *activating* polypeptide ( PACAP ) and [tissue plasminogen activator (tPA)] play important roles in neuronal migration and survival . Positive_regulation PLAT ADCY8 21919910 2506841 Pituitary *activating* polypeptide ( PACAP ) and [tissue plasminogen activator (tPA)] play important roles in neuronal migration and survival . Positive_regulation PLAT ADCY9 21919910 2506842 Pituitary *activating* polypeptide ( PACAP ) and [tissue plasminogen activator (tPA)] play important roles in neuronal migration and survival . Positive_regulation PLAT ADCYAP1 11870092 918411 When granulosa cells were stimulated within the intact follicle ( i.e. , maintaining the three-dimensional structure and in the presence of the theca cell layers ) , both and VIP dose-dependently *stimulated* [tPA] . Positive_regulation PLAT ADCYAP1 21919910 2506844 In this study , we show that , in PC12 cells , *induced* a 9.85-fold increase in [tPA] gene expression through activation of the protein kinase A- and protein kinase C-dependent signaling pathways . Positive_regulation PLAT ADCYAP1 21919910 2506845 In immature cerebellar granule neurons (CGN) , *stimulated* [tPA] mRNA expression and release of proteolytically active tPA . Positive_regulation PLAT ADCYAP1 21919910 2506846 Altogether , these data indicate that [tPA] gene expression is *activated* by in both tumoral and normal neuronal cells . Positive_regulation PLAT ADCYAP1 21919910 2506847 The present study also demonstrates that *stimulates* the release of [tPA] which promotes CGN survival by a mechanism dependent of its proteolytic activity . Positive_regulation PLAT AKT1 20440070 2268334 In contrast , tPA induced delayed IPC required the proteolytic activity of [tPA] and was *mediated* by plasmin , the NMDA receptor , and phosphorylation . Positive_regulation PLAT AKT1 23562854 2778005 Glucose deprivation induced activation of , p38 and AMPK , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced [tPA] down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation PLAT AKT2 23562854 2778006 Glucose deprivation induced activation of , p38 and AMPK , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced [tPA] down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation PLAT AKT3 23562854 2778007 Glucose deprivation induced activation of , p38 and AMPK , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced [tPA] down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation PLAT ANG 7991590 282953 Binding of angiogenin to its cell-surface binding protein ( actin ) followed by dissociation of the complex from the cell surface and subsequent *activation* of [tissue-type plasminogen activator/plasmin] are likely steps involved in the processes of endothelial cell invasion and angiogenesis . Positive_regulation PLAT ANG 9330225 457510 Plasminogen accelerated inactivation of angiogenin by elastase might be a significant event in the process of angiogenin induced angiogenesis since ( i ) angiogenin and plasminogen circulate in plasma at high concentrations , ( ii ) , especially when bound to actin , *activates* [tissue plasminogen activator] to generate plasmin from plasminogen , and ( iii ) elastase cleaves plasminogen to produce angiostatin , a potent inhibitor of angiogenesis and metastasis . Positive_regulation PLAT ANGPT2 21786025 2476559 Based on above results , may induced cerebral aneurysm , ischemia/infarction on brain through RAS system by down regulating the mRNA levels of MMP 2 , uPA , PAI , PPAR-A , MCSF1 and up *regulating* [tPA] and MCP-1 and ß carotene attenuates the disease condition and bring down to normal expression levels of above genes . Positive_regulation PLAT ANXA2 15257287 1274352 siRNA mediated downregulation of and disruption of the complex by microinjection of peptide competitors *result* in a marked reduction in vWF but not [tPA] secretion , without affecting the appearance of WPbs . Positive_regulation PLAT ANXA2 22162045 2549123 Furthermore , we demonstrated that and Galectin-1 receptors are *involved* in [tPA] signaling and inflammatory response in glial cells . Positive_regulation PLAT APOB 10845890 700683 The present study demonstrated that treatment with antioxidants , butylated hydroxytoluene or vitamin E , blocked native LDL- and glycated *induced* changes in PAI-1 and [tPA] generation in ECs . Positive_regulation PLAT APOB 10845890 700685 Cotreatment with native or glycated HDL inhibited LDL induced or glycated *induced* changes in PAI-1 and [tPA] generation in ECs . Positive_regulation PLAT APOB 10845890 700687 The effects of antioxidants and HDL on LDL induced or its glycated *induced* changes in the generation of PAI-1 and [tPA] were also found in cultured human coronary artery ECs . Positive_regulation PLAT APOB 12167592 973164 slightly *increased* [tPA] release at hours 24 and 48 but did not increase PA activity in culture medium . Positive_regulation PLAT APOB 12167592 973169 In summary , *regulates* PAI-1 , uPA , and [tPA] in biphasic patterns in HMC , and the upregulation of PAI-1 , uPA , and tPA after long-term LDL exposure seems to be mediated by a delayed PKC activation associated with an increased PA inhibitory activity . Positive_regulation PLAT APOB 15708180 1372948 The total cholesterol , and sVCAM-1 ( from 394.4+/-251.7 to 321.0+/-198.9 ng/ml , p < 0.05 ) all decreased significantly and the [tPA] ( from 9.47+/-3.57 to 11.62+/-3.99 ng/ml , p < 0.05 ) *increased* significantly after atorvastatin treatment . Positive_regulation PLAT APOB 16037259 1437235 Glycation does not alter *induced* secretion of [tissue plasminogen activator] and plasminogen activator inhibitor-1 from human aortic endothelial cells . Positive_regulation PLAT APOB 16037259 1437237 Using LDL of different density subclasses , [tPA] and PAI-1 release in *response* to from diabetic patients compared with control subjects did not differ when HAECs were incubated with LDLs of increasing density isolated from each subject pair . Positive_regulation PLAT APOB 9672075 520079 Treatment with 25 mmol/L aminoguanidine , an antioxidant and inhibitor of the formation of advanced glycation end products , during glycation normalized glycated *induced* generation of PAI-1 and [tPA] in ECs . Positive_regulation PLAT APOH 19180513 2033176 In addition , bound tPA with high affinity ( K ( d ) approximately 20 nM ) , *stimulated* [tPA] amidolytic activity , and caused an overall 20-fold increase in the catalytic efficiency ( K ( cat ) /K ( m ) ) of tPA mediated conversion of Glu-plasminogen to plasmin . Positive_regulation PLAT ARG1 21394642 2562061 ( 9 ) -bradykinin *had* no effect on blood flow or [tissue plasminogen activator] release . Positive_regulation PLAT ARG2 21394642 2562062 ( 9 ) -bradykinin *had* no effect on blood flow or [tissue plasminogen activator] release . Positive_regulation PLAT ASIP 8030371 263746 To examine whether the epidermal growth factor (EGF)-like domain is *involved* in the interaction of [tissue plasminogen activator (t-PA)] with platelets , we have expressed this domain in E. coli . Positive_regulation PLAT B3GAT1 20338610 2327181 HA/CMC and the NK-1RA alone as well as *increased* peritoneal [tPA] activity by 124 % , 432 % , and 192 % , respectively ( P < .05 ) compared with saline controls . Positive_regulation PLAT BDNF 10215917 608231 *stimulates* expression , activity and release of [tissue-type plasminogen activator] in mouse cortical neurons . Positive_regulation PLAT BDNF 10215917 608232 Here , we report that *stimulates* the expression of [tissue-type plasminogen activator] ( tPA ) in primary cultures of cortical neurons in a time- and concentration dependent manner . Positive_regulation PLAT BDNF 10215917 608234 *Induction* of [tPA] expression by is accompanied by an increase in the proteolytic activity of tPA associated with cortical neurons and a release of tPA into the extracellular space . Positive_regulation PLAT BDNF 10215917 608235 Release of [tPA] *induced* by depends on extracellular Ca2+ since it is markedly reduced in the presence of ethylene glycol-bis ( beta-aminoethylether ) -N , N,N ' , N'-tetraacetic acid ( EGTA ) . Positive_regulation PLAT BDNF 10215917 608239 *Up-regulation* of [tPA] expression by is followed by the induction of plasminogen activator inhibitor 2 ( PAI-2 ) , an inhibitor of tPA . Positive_regulation PLAT BDNF 10215917 608241 Together these results suggest that *activation* of [tPA] by may contribute to structural changes associated with neuronal development or synaptic plasticity . Positive_regulation PLAT BDNF 17179157 1695156 Further analysis revealed that induction of SNAT1 expression and System A activity by is *necessary* in particular to enhance synthesis of [tissue-type plasminogen activator] , a protein that we demonstrate to be essential for the effects of BDNF on cortical dendritic morphology . Positive_regulation PLAT BDNF 21615740 2464390 Zinc triggered *induction* of [tissue plasminogen activator] by and metalloproteinases . Positive_regulation PLAT BMP7 16806868 1599833 *increased* SERPINE2 secretion and expression and [tPA] secretion . Positive_regulation PLAT CA2 9351387 461129 In this study , we investigated the *role* of and G proteins in thrombin induced acute release ( regulated secretion ) of [tissue-type plasminogen activator (TPA)] and von Willebrand factor (vWF) , using a previously described system of primary human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation PLAT CALCA 3017447 62079 In UMR 106-06 cells , which unlike UMR 106-01 cells show a cyclic AMP response to calcitonin , [tPA] activity was also increased in *response* to , and the effect was enhanced by IBMX . Positive_regulation PLAT CCL4 23831191 2870693 *induces* [tissue-type plasminogen activator] in rat brain ; Positive_regulation PLAT CDC73 12241114 989683 *stimulated* [tPA] release into the conditioned medium . Positive_regulation PLAT CDC73 1521562 196957 Using a perfused rat hindleg system , release of [tissue-type plasminogen activator (t-PA)] from endothelial cells could be *induced* by , bradykinin , substance P , thrombin , carbachol and A23187 , while this release was inhibited by mepacrine and by nor-dihydroguaiaretic acid . Positive_regulation PLAT CDC73 1719289 169606 The effect of BL 194 on *induced* release of [tPA] and vWF could be mimicked by isobutyl-methylxanthine ( IBMX ) , an inhibitor of phosphodiesterases . Positive_regulation PLAT CDC73 1719289 169611 In vivo , BL 194 and pentoxifylline did not affect baseline levels of plasma tPA and PA inhibitor activity , nor did these compounds affect the in vivo *induction* of [tPA] release by . Positive_regulation PLAT CDC73 3924144 49100 *induced* release of [tissue-type plasminogen activator] from vessel walls . Positive_regulation PLAT CGA 16514196 1530786 The results suggest that surge *induced* regulation of tissue inhibitor of metalloproteinase-4 and [tissue plasminogen activator] may be prostanoid dependent , and support a potential role for increased tissue plasminogen activator expression and decreased tissue inhibitor of metalloproteinase-4 expression in the mechanism of ovulation . Positive_regulation PLAT CGA 18818294 2012687 Therefore , *increases* granulosa cell [tPA] and PAI-1 protein levels and tPA dependent proteolytic activity . Positive_regulation PLAT CGA 9687315 522182 This suggests that the dose- and time dependent decrease in the *induced* [tPA] activity in the culture by the presence of PRL may be due to decreasing tPA mRNA synthesis on one hand and to neutralization of the tPA activity by the increased PAI-I activity on the other . Positive_regulation PLAT CGB8 16514196 1530785 The results suggest that surge *induced* regulation of tissue inhibitor of metalloproteinase-4 and [tissue plasminogen activator] may be prostanoid dependent , and support a potential role for increased tissue plasminogen activator expression and decreased tissue inhibitor of metalloproteinase-4 expression in the mechanism of ovulation . Positive_regulation PLAT CGB8 18818294 2012686 Therefore , *increases* granulosa cell [tPA] and PAI-1 protein levels and tPA dependent proteolytic activity . Positive_regulation PLAT CGB8 9687315 522181 This suggests that the dose- and time dependent decrease in the *induced* [tPA] activity in the culture by the presence of PRL may be due to decreasing tPA mRNA synthesis on one hand and to neutralization of the tPA activity by the increased PAI-I activity on the other . Positive_regulation PLAT CLEC3B 12694198 1080669 The kinetic parameters of the *stimulated* enhancement of [tPA] were comparable to fibrinogen fragments , which are so far the best inducer of tPA catalysed plasminogen activation . Positive_regulation PLAT CLEC3B 19152657 2026839 *enhances* plasminogen activation by a [tissue-type plasminogen activator] so that it has been suggested to play a role in tissue remodeling . Positive_regulation PLAT CMC1 20338610 2327179 HA/CMC and the NK-1RA alone as well as *increased* peritoneal [tPA] activity by 124 % , 432 % , and 192 % , respectively ( P < .05 ) compared with saline controls . Positive_regulation PLAT CMC2 20338610 2327178 and the NK-1RA alone as well as HA/CMC+NK-1RA *increased* peritoneal [tPA] activity by 124 % , 432 % , and 192 % , respectively ( P < .05 ) compared with saline controls . Positive_regulation PLAT CMC4 20338610 2327180 and the NK-1RA alone as well as HA/CMC+NK-1RA *increased* peritoneal [tPA] activity by 124 % , 432 % , and 192 % , respectively ( P < .05 ) compared with saline controls . Positive_regulation PLAT CPB1 15105189 1240503 Overall , the combined strategy was associated with a reduction in *induced* increases in markers of thrombin generation , fibrin formation , [tPA] release , and fibrin degradation and better preservation of PAI-1 . Positive_regulation PLAT CPB1 22003219 2513216 activation of the kallikrein-kinin system *increases* activated factor XIIa , kallikrein , bradykinin , and [tissue plasminogen activator] levels , but has little effect on thrombin generation . Positive_regulation PLAT CPB2 15105189 1240504 Overall , the combined strategy was associated with a reduction in *induced* increases in markers of thrombin generation , fibrin formation , [tPA] release , and fibrin degradation and better preservation of PAI-1 . Positive_regulation PLAT CPB2 22003219 2513217 activation of the kallikrein-kinin system *increases* activated factor XIIa , kallikrein , bradykinin , and [tissue plasminogen activator] levels , but has little effect on thrombin generation . Positive_regulation PLAT CSF2 1707693 155061 and G-CSF ( 1 ng/mL to 1 microgram/mL ) *had* no effect on the expression of either [tissue plasminogen activator (tPA)] or plasminogen activator inhibitor-1 ( PAI-1 ) by endothelial cells . Positive_regulation PLAT CSF3 1707693 155062 GM-CSF and ( 1 ng/mL to 1 microgram/mL ) *had* no effect on the expression of either [tissue plasminogen activator (tPA)] or plasminogen activator inhibitor-1 ( PAI-1 ) by endothelial cells . Positive_regulation PLAT CTR9 12241114 989684 *stimulated* [tPA] release into the conditioned medium . Positive_regulation PLAT CTR9 1521562 196958 Using a perfused rat hindleg system , release of [tissue-type plasminogen activator (t-PA)] from endothelial cells could be *induced* by , bradykinin , substance P , thrombin , carbachol and A23187 , while this release was inhibited by mepacrine and by nor-dihydroguaiaretic acid . Positive_regulation PLAT CTR9 1719289 169607 The effect of BL 194 on *induced* release of [tPA] and vWF could be mimicked by isobutyl-methylxanthine ( IBMX ) , an inhibitor of phosphodiesterases . Positive_regulation PLAT CTR9 1719289 169612 In vivo , BL 194 and pentoxifylline did not affect baseline levels of plasma tPA and PA inhibitor activity , nor did these compounds affect the in vivo *induction* of [tPA] release by . Positive_regulation PLAT CTR9 3924144 49101 *induced* release of [tissue-type plasminogen activator] from vessel walls . Positive_regulation PLAT CUL1 9430489 482105 The c-kit ligand *upregulates* uPAR expression , and the release of [tPA] from MC . Positive_regulation PLAT EDN1 1644323 194868 *increased* the [tissue type plasminogen activator] release and platelet activating factor formation , and induced subsequent gastric mucosal haemorrhagic change in a dose dependent manner . Positive_regulation PLAT EDN1 2125563 146737 and -3 *induce* the release of [tissue-type plasminogen activator] and von Willebrand factor from endothelial cells . Positive_regulation PLAT EDN3 2125563 146738 *induce* the release of [tissue-type plasminogen activator] and von Willebrand factor from endothelial cells . Positive_regulation PLAT EEF1A2 18599869 1947149 In addition to reducing TM upregulation , inhibition of HSF1 reduced *induced* upregulation of [tissue plasminogen activator] , whereas downregulation of thrombomospondin , plasminogen activator inhibitor 1 , or connective tissue growth factor was unaffected . Positive_regulation PLAT EGF 10377062 623529 In the *presence* of , however , some activity of [tPA-PAI] was detected at 12 h of culture . Positive_regulation PLAT EGF 11814314 892822 We have examined expression of the components of the plasminogen activation system in human astrocytoma U373-MG cells and found that interleukin 1beta (IL-1beta) , tumour necrosis factor alpha TNF-alpha ) , interferon gamma (INF-gamma) and specifically *regulate* the expression of [tissue-type plasminogen activator (t-PA)] , urokinase-type plasminogen activator ( u-PA ) , plasminogen activator inhibitor type 1 ( PAI-1 ) and protease nexin-1 (PN-1) . Positive_regulation PLAT EGF 1537881 180629 We have previously demonstrated that *induces* cell migration , [tissue-type plasminogen activator] synthesis , as well as tubular formation in microvascular endothelial cells from human omental tissue . Positive_regulation PLAT EGF 1654897 166175 *induces* tubular formation of cultured human omental microvascular endothelial ( HOME ) cells and EGF also stimulates cell migration as well as expression of [tissue type plasminogen activator (t-PA)] . Positive_regulation PLAT EGF 16806868 1599837 inhibited SERPINE2 secretion and expression , but *increased* secreted [tPA] activity . Positive_regulation PLAT EGF 2128970 150616 It has previously been reported that *enhances* uPA but not [tPA] in the A431 squamous carcinoma cell line . Positive_regulation PLAT EGF 2128970 150619 Under conditions in which *had* no effect on [tPA] activity , tPA antigen paradoxically increased with a concomitant rise of tPA/PAI-1 complexes . Positive_regulation PLAT EGF 2133249 150698 We found that , under conditions in which *had* no effect on [tPA] activity , tPA antigen increased with a concomitant rise of tPA/PAI-1 complexes , indicating the action of an inhibitor . Positive_regulation PLAT EGF 2168711 140367 The aim of the present study was to determine whether specific tPA receptors or receptors *mediate* the binding of [tPA] to cells and whether tPA possesses intrinsic mitogenic activity . Positive_regulation PLAT EGF 2509602 120466 *increases* the production of [tissue plasminogen activator (t-PA)] and activates the aromatase activity of the both cell types . Positive_regulation PLAT EGF 2544397 114030 While FSH and GnRH are known to stimulate accumulation of tissue-type plasminogen activator ( tPA ) mRNA in granulosa cells , studies using nonovarian cells have shown *stimulation* of [tPA] by . Positive_regulation PLAT EGF 7508907 244851 or transforming growth factor-alpha ( TGF-alpha ) *stimulated* cell migration , chemotaxis , and the expression of [tissue-type plasminogen activator (t-PA)] in human omental microvascular endothelial ( HOME ) cells . Positive_regulation PLAT EGF 7679996 211337 and TGF-alpha *induced* expression of [tPA] in HOME cells , while IGF-1 and HGF did not . Positive_regulation PLAT EGFR 17452424 1778058 Firstly , we found that [tPA] *induced* a rapid and transient phosphorylation of the . Positive_regulation PLAT EGFR 17452424 1778059 The mitogenic activity of [tPA] was also *inhibited* by siRNA depletion of , thus confirming the involvement of this receptor in tPA triggered signalling . Positive_regulation PLAT EPHB2 23731391 2853954 Our recent work shows that a catalytically inactive tPA variant ( tPA-S ( 481 ) A ) that competes with endogenous wild type ( wt ) tPA for binding to NMDA-R through its receptor docking site but that can not activate it , prevents *activation* of by wt [tPA] and impairment of autoregulation when administered 30 min after fluid percussion injury ( FPI ) . Positive_regulation PLAT F10 10037444 592122 When added to confluent HUVEC , *induced* the expression of tissue factor and the release of [tissue-type plasminogen activator] and plasminogen activator inhibitor-1 without affecting urokinase expression . Positive_regulation PLAT F12 12182909 977916 *increased* transiently after rt-PA but not after [TNK-tPA] . Positive_regulation PLAT F2R 9379363 465874 The effects of different flavonoids isolated from the roots of Scutellaria baicalensis Georgi on the production of [tissue-type plasminogen activator (t-PA)] and plasminogen activator inhibitor-1 ( PAI-1 ) *induced* by thrombin and agonist peptide , Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe , have been examined in cultured human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation PLAT F7 10331509 614661 *Activation* of by [tissue-type plasminogen activator] . Positive_regulation PLAT F8 9427706 481725 Systemic administration of desmopressin ( DDAVP ) *induces* increased plasma levels of [tissue-type plasminogen activator (t-PA)] , , and von Willebrand factor (vWF) . Positive_regulation PLAT FGA 2128181 149286 The amidolytic activity of one-chain [tissue-type plasminogen activator] was *stimulated* by intact and somewhat more strongly by fibrin X-fragment . Positive_regulation PLAT FGB 10351993 617098 As fasting insulin concentrations increased , postloading insulin , glucose , blood pressure , body mass index , waist-to-hip ratio , total cholesterol , triglycerides , LDL-cholesterol , apoprotein B , plasminogen activator inhibitor 1 , [tissue plasminogen activator] , and *increased* , but lipoprotein(a) , HDL-cholesterol , and apoprotein A1 decreased . Positive_regulation PLAT FGB 1693270 132747 Moreover , vitronectin was found to inhibit in a dose dependent fashion the induced *activation* of plasminogen by [tissue plasminogen activator] . Positive_regulation PLAT FGB 1903067 156106 These results indicate that *enhances* the amidolytic activity of single chain [tPA] by binding to kringle 2 domain or light chain through D domain of fibrinogen . Positive_regulation PLAT FGB 2128181 149287 The amidolytic activity of one-chain [tissue-type plasminogen activator] was *stimulated* by intact and somewhat more strongly by fibrin X-fragment . Positive_regulation PLAT FGB 3130631 92688 Activation in serum of human [ Glu1 ] plasminogen ( [ Glu1 ] Pg ) by recombinant [tissue plasminogen activator] was inhibited by the normal serum levels of Cl- and was *enhanced* by physiological levels of in the presence or absence of Cl- . Positive_regulation PLAT FGB 9179603 434375 In the early phase , a significant increase in level was *followed* by increases in the activities of plasminogen and [tissue-type plasminogen activator] with a decrease in alpha 2-plasmin inhibitor activity and platelet count . Positive_regulation PLAT FGF2 10367292 621360 In [tPA] , 50 and 100 ng/mL *increased* PGI2 production from 1.98 +/- 0.14 to 3.5 +/- 1.05 and 3.96 +/- 0.46 ( p < 0.02 ) . Positive_regulation PLAT FGF2 12008951 940760 mRNA analysis revealed that FGF-1 , and FGF-4 *induced* the mRNA expression levels of uPA , [tPA] , uPAR , PAI-1 and PAI-2 , and reduced those of IGF-1 , IGF-1R , IGF-2R and IGFBP-4 , without significantly affecting the levels of IGFBP-3 , IGFBP-5 and IGFBP-6 mRNA . Positive_regulation PLAT FGF2 1324147 194937 Furthermore , *stimulated* [tissue plasminogen activator] activity in a dose dependent manner , and FSH primed granulosa cells were more responsive to bFGF action , with a decrease in the ED50 from 5.0 to 1.5 ng/ml . Positive_regulation PLAT FGF2 20018898 2204793 We demonstrate that in HUVECs , TM601 inhibits both vascular endothelial growth factor- and *induced* [tissue plasminogen activator] activation , which is required for activation of plasminogen to plasmin . Positive_regulation PLAT FGF2 2171912 144121 *induction* of granulosa cell [tissue-type plasminogen activator] expression and oocyte maturation : potential role as a paracrine ovarian hormone . Positive_regulation PLAT FGF2 7701477 297562 PDGF , and serum *increased* [tPA] ( serum > PDGF > FGF ) . Positive_regulation PLAT FGF2 9106134 424358 The [tissue plasminogen activator (t-PA)] activity was *enhanced* by . Positive_regulation PLAT FGF2 9124280 419477 Although IL-4 had no effects on SMC tPA , UPA , and PAI-1 production , it potentiated *induced* [tPA] , UPA , and PAI-1 antigens . Positive_regulation PLAT FGF2 9124280 419499 IFN-gamma did not significantly affect *induction* of SMC [tPA] and PAI-1 antigens . Positive_regulation PLAT FGF2 9124280 419503 IFN-gamma decreased the IL-4 plus *induction* of both [tPA] and UPA antigens . Positive_regulation PLAT FGF2 9307014 454344 Heparin abrogated *induced* release of [tissue-type plasminogen activator] by these cells . Positive_regulation PLAT FGF4 12008951 940761 mRNA analysis revealed that FGF-1 , FGF-2 and *induced* the mRNA expression levels of uPA , [tPA] , uPAR , PAI-1 and PAI-2 , and reduced those of IGF-1 , IGF-1R , IGF-2R and IGFBP-4 , without significantly affecting the levels of IGFBP-3 , IGFBP-5 and IGFBP-6 mRNA . Positive_regulation PLAT FGG 2128181 149288 The amidolytic activity of one-chain [tissue-type plasminogen activator] was *stimulated* by intact and somewhat more strongly by fibrin X-fragment . Positive_regulation PLAT GH1 8206322 261189 *induction* of rat granulosa cell [tissue-plasminogen activator] expression and progesterone synthesis . Positive_regulation PLAT GIF 11814314 892823 We have examined expression of the components of the plasminogen activation system in human astrocytoma U373-MG cells and found that interleukin 1beta (IL-1beta) , tumour necrosis factor alpha TNF-alpha ) , and epidermal growth factor (EGF) specifically *regulate* the expression of [tissue-type plasminogen activator (t-PA)] , urokinase-type plasminogen activator ( u-PA ) , plasminogen activator inhibitor type 1 ( PAI-1 ) and protease nexin-1 (PN-1) . Positive_regulation PLAT GNRH1 1801839 176969 Similar to hCG , also *increases* [tPA] activity in cumulus-oocyte complexes in a time dependent fashion . Positive_regulation PLAT GNRH1 3114254 77526 *induced* [tissue-type PA (tPA)] secretion by cultured rat granulosa cells , but inhibited the secretion of urokinase-type PA . Positive_regulation PLAT GNRH1 3139993 99618 Our data suggest that FSH and *increase* the [tPA] mRNA levels by two distinct pathways in cultured granulosa cells , providing a model system for studying the hormonal regulation of tPA gene expression . Positive_regulation PLAT HCG11 9433919 474500 Our previous studies have demonstrated that rat epididymis expressed luteinizing hormone receptor (LHR) , tissue type ( t ) and urokinase type ( u ) PA , mRNAs , and [tPA] activity was *stimulated* in vitro by . Positive_regulation PLAT HCG11 9433919 474518 In-vitro experiments showed that both [tPA] and uPA activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAT HCG11 9455847 475592 PRL also suppressed *induced* [tPA] gene expression in a dose- and time dependent manner . Positive_regulation PLAT HCG14 9433919 474501 Our previous studies have demonstrated that rat epididymis expressed luteinizing hormone receptor (LHR) , tissue type ( t ) and urokinase type ( u ) PA , mRNAs , and [tPA] activity was *stimulated* in vitro by . Positive_regulation PLAT HCG14 9433919 474519 In-vitro experiments showed that both [tPA] and uPA activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAT HCG14 9455847 475593 PRL also suppressed *induced* [tPA] gene expression in a dose- and time dependent manner . Positive_regulation PLAT HCG15 9433919 474502 Our previous studies have demonstrated that rat epididymis expressed luteinizing hormone receptor (LHR) , tissue type ( t ) and urokinase type ( u ) PA , mRNAs , and [tPA] activity was *stimulated* in vitro by . Positive_regulation PLAT HCG15 9433919 474520 In-vitro experiments showed that both [tPA] and uPA activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAT HCG15 9455847 475594 PRL also suppressed *induced* [tPA] gene expression in a dose- and time dependent manner . Positive_regulation PLAT HCG16 9433919 474505 Our previous studies have demonstrated that rat epididymis expressed luteinizing hormone receptor (LHR) , tissue type ( t ) and urokinase type ( u ) PA , mRNAs , and [tPA] activity was *stimulated* in vitro by . Positive_regulation PLAT HCG16 9433919 474523 In-vitro experiments showed that both [tPA] and uPA activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAT HCG16 9455847 475597 PRL also suppressed *induced* [tPA] gene expression in a dose- and time dependent manner . Positive_regulation PLAT HCG17 9433919 474516 Our previous studies have demonstrated that rat epididymis expressed luteinizing hormone receptor (LHR) , tissue type ( t ) and urokinase type ( u ) PA , mRNAs , and [tPA] activity was *stimulated* in vitro by . Positive_regulation PLAT HCG17 9433919 474534 In-vitro experiments showed that both [tPA] and uPA activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAT HCG17 9455847 475608 PRL also suppressed *induced* [tPA] gene expression in a dose- and time dependent manner . Positive_regulation PLAT HCG18 9433919 474515 Our previous studies have demonstrated that rat epididymis expressed luteinizing hormone receptor (LHR) , tissue type ( t ) and urokinase type ( u ) PA , mRNAs , and [tPA] activity was *stimulated* in vitro by . Positive_regulation PLAT HCG18 9433919 474533 In-vitro experiments showed that both [tPA] and uPA activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAT HCG18 9455847 475607 PRL also suppressed *induced* [tPA] gene expression in a dose- and time dependent manner . Positive_regulation PLAT HCG20 9433919 474513 Our previous studies have demonstrated that rat epididymis expressed luteinizing hormone receptor (LHR) , tissue type ( t ) and urokinase type ( u ) PA , mRNAs , and [tPA] activity was *stimulated* in vitro by . Positive_regulation PLAT HCG20 9433919 474531 In-vitro experiments showed that both [tPA] and uPA activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAT HCG20 9455847 475605 PRL also suppressed *induced* [tPA] gene expression in a dose- and time dependent manner . Positive_regulation PLAT HCG21 9433919 474514 Our previous studies have demonstrated that rat epididymis expressed luteinizing hormone receptor (LHR) , tissue type ( t ) and urokinase type ( u ) PA , mRNAs , and [tPA] activity was *stimulated* in vitro by . Positive_regulation PLAT HCG21 9433919 474532 In-vitro experiments showed that both [tPA] and uPA activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAT HCG21 9455847 475606 PRL also suppressed *induced* [tPA] gene expression in a dose- and time dependent manner . Positive_regulation PLAT HCG22 9433919 474511 Our previous studies have demonstrated that rat epididymis expressed luteinizing hormone receptor (LHR) , tissue type ( t ) and urokinase type ( u ) PA , mRNAs , and [tPA] activity was *stimulated* in vitro by . Positive_regulation PLAT HCG22 9433919 474529 In-vitro experiments showed that both [tPA] and uPA activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAT HCG22 9455847 475603 PRL also suppressed *induced* [tPA] gene expression in a dose- and time dependent manner . Positive_regulation PLAT HCG23 9433919 474503 Our previous studies have demonstrated that rat epididymis expressed luteinizing hormone receptor (LHR) , tissue type ( t ) and urokinase type ( u ) PA , mRNAs , and [tPA] activity was *stimulated* in vitro by . Positive_regulation PLAT HCG23 9433919 474521 In-vitro experiments showed that both [tPA] and uPA activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAT HCG23 9455847 475595 PRL also suppressed *induced* [tPA] gene expression in a dose- and time dependent manner . Positive_regulation PLAT HCG24 9433919 474509 Our previous studies have demonstrated that rat epididymis expressed luteinizing hormone receptor (LHR) , tissue type ( t ) and urokinase type ( u ) PA , mRNAs , and [tPA] activity was *stimulated* in vitro by . Positive_regulation PLAT HCG24 9433919 474527 In-vitro experiments showed that both [tPA] and uPA activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAT HCG24 9455847 475601 PRL also suppressed *induced* [tPA] gene expression in a dose- and time dependent manner . Positive_regulation PLAT HCG25 9433919 474504 Our previous studies have demonstrated that rat epididymis expressed luteinizing hormone receptor (LHR) , tissue type ( t ) and urokinase type ( u ) PA , mRNAs , and [tPA] activity was *stimulated* in vitro by . Positive_regulation PLAT HCG25 9433919 474522 In-vitro experiments showed that both [tPA] and uPA activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAT HCG25 9455847 475596 PRL also suppressed *induced* [tPA] gene expression in a dose- and time dependent manner . Positive_regulation PLAT HCG26 9433919 474512 Our previous studies have demonstrated that rat epididymis expressed luteinizing hormone receptor (LHR) , tissue type ( t ) and urokinase type ( u ) PA , mRNAs , and [tPA] activity was *stimulated* in vitro by . Positive_regulation PLAT HCG26 9433919 474530 In-vitro experiments showed that both [tPA] and uPA activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAT HCG26 9455847 475604 PRL also suppressed *induced* [tPA] gene expression in a dose- and time dependent manner . Positive_regulation PLAT HCG27 9433919 474510 Our previous studies have demonstrated that rat epididymis expressed luteinizing hormone receptor (LHR) , tissue type ( t ) and urokinase type ( u ) PA , mRNAs , and [tPA] activity was *stimulated* in vitro by . Positive_regulation PLAT HCG27 9433919 474528 In-vitro experiments showed that both [tPA] and uPA activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAT HCG27 9455847 475602 PRL also suppressed *induced* [tPA] gene expression in a dose- and time dependent manner . Positive_regulation PLAT HCG4 9433919 474506 Our previous studies have demonstrated that rat epididymis expressed luteinizing hormone receptor (LHR) , tissue type ( t ) and urokinase type ( u ) PA , mRNAs , and [tPA] activity was *stimulated* in vitro by . Positive_regulation PLAT HCG4 9433919 474524 In-vitro experiments showed that both [tPA] and uPA activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAT HCG4 9455847 475598 PRL also suppressed *induced* [tPA] gene expression in a dose- and time dependent manner . Positive_regulation PLAT HCG8 9433919 474507 Our previous studies have demonstrated that rat epididymis expressed luteinizing hormone receptor (LHR) , tissue type ( t ) and urokinase type ( u ) PA , mRNAs , and [tPA] activity was *stimulated* in vitro by . Positive_regulation PLAT HCG8 9433919 474525 In-vitro experiments showed that both [tPA] and uPA activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAT HCG8 9455847 475599 PRL also suppressed *induced* [tPA] gene expression in a dose- and time dependent manner . Positive_regulation PLAT HCG9 9433919 474508 Our previous studies have demonstrated that rat epididymis expressed luteinizing hormone receptor (LHR) , tissue type ( t ) and urokinase type ( u ) PA , mRNAs , and [tPA] activity was *stimulated* in vitro by . Positive_regulation PLAT HCG9 9433919 474526 In-vitro experiments showed that both [tPA] and uPA activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAT HCG9 9455847 475600 PRL also suppressed *induced* [tPA] gene expression in a dose- and time dependent manner . Positive_regulation PLAT HGF 10064822 593463 These results are consistent with the hypothesis that plays a role in the development and maintenance of both the cerebral cortex and hippocampus , and that [tPA] may *act* as a regulator of HGF/SF activity in these structures . Positive_regulation PLAT HGF 24536011 2915055 inhibited formation of abdominal adhesions after hepatectomy by reducing IFN-? and PAI-1 levels , and *increasing* [tPA] levels compared with those in mice treated with phosphate buffered saline ( P < 0·001 , P = 0·002 and P = 0·035 respectively ) . Positive_regulation PLAT HRAS 11437413 832805 Surprisingly , low-dose *enhanced* the activity of [tissue-type plasminogen activator] ( tPA ) , and activated pro-matrix metalloproteinases ( proMMP2 and proMMP9 ) . Positive_regulation PLAT HRG 9102401 419237 In contrast , native bound to hydrazide or nickel chelate surfaces strongly *stimulated* the activation of plasminogen by [tissue plasminogen activator] , but not by urokinase or streptokinase . Positive_regulation PLAT HSF1 18599869 1947150 In addition to reducing TM upregulation , inhibition of *reduced* statin induced upregulation of [tissue plasminogen activator] , whereas downregulation of thrombomospondin , plasminogen activator inhibitor 1 , or connective tissue growth factor was unaffected . Positive_regulation PLAT HSPG2 17264956 1691417 Acute [tissue-type plasminogen activator] release in human microvascular endothelial cells : the *roles* of Galphaq , , IP3 and 5,6-epoxyeicosatrienoic acid . Positive_regulation PLAT HTC1 2936742 57082 The PA inhibitor rapidly *inhibits* urokinase and [tissue plasminogen activator] with an apparent second-order rate constant of 3-5 x 10 ( 7 ) M-1 X s-1 . Positive_regulation PLAT HTC2 2936742 57083 The PA inhibitor rapidly *inhibits* urokinase and [tissue plasminogen activator] with an apparent second-order rate constant of 3-5 x 10 ( 7 ) M-1 X s-1 . Positive_regulation PLAT IGFBP5 16505491 1549073 Furthermore , we noted that IGFBP-5 activated plasminogen to a greater extent than could be explained solely by inhibition of PAI-1 , suggesting that could directly *activate* [tPA] . Positive_regulation PLAT IGFBP5 16505491 1549076 These data demonstrate that can *enhance* the activity of [tPA] and that this can result in cell death induced by cleavage of focal adhesions . Positive_regulation PLAT IL1A 12123742 965552 Both drugs inhibited the *induced* mRNA expression of [tPA] , whereas expression of uPA was only mildly reduced by PSGAG , which also induced PAI-1 above IL-1 stimulated levels . Positive_regulation PLAT IL1A 12234061 988794 All tested NSAIDs dose dependently inhibited the *induced* mRNA expression of [tPA] , whereas only indomethacin and tiaprofenic acid were also able to reduce the expression of uPA . Positive_regulation PLAT IL1A 16410064 1513620 Examination of the signal transduction pathways leading to *upregulation* of [tissue type plasminogen activator] by in human pulp cells . Positive_regulation PLAT IL1A 16953813 1610999 Signal transduction pathways involved in the *stimulation* of [tissue type plasminogen activator] by and Porphyromonas gingivalis in human osteosarcoma cells . Positive_regulation PLAT IL1B 10743860 680564 Our previous studies had demonstrated that in inflamed gingival tissues , [tissue-type plasminogen activator (t-PA)] is significantly increased in the extracellular matrix of the connective tissue and that can up *regulate* the level of t-PA and plasminogen activator inhibitor-2 ( PAI-2 ) synthesis by human gingival fibroblasts . Positive_regulation PLAT IL1B 11786081 901233 *induced* [tPA] and plasminogen activator inhibitor (PAI)-1 mRNA and supernatant tPA antigen were significantly inhibited by both NO donors , which resulted in a net decrease in the IL-1beta evoked tPA enzyme activity in the conditioned media . Positive_regulation PLAT IL1B 11786081 901234 In contrast , HXXO caused a marked amplification of the *induced* steady-state tPA mRNA level and [tPA] enzyme activity that was blocked by catalase . Positive_regulation PLAT IL1B 11814314 892824 We have examined expression of the components of the plasminogen activation system in human astrocytoma U373-MG cells and found that , tumour necrosis factor alpha TNF-alpha ) , interferon gamma (INF-gamma) and epidermal growth factor (EGF) specifically *regulate* the expression of [tissue-type plasminogen activator (t-PA)] , urokinase-type plasminogen activator ( u-PA ) , plasminogen activator inhibitor type 1 ( PAI-1 ) and protease nexin-1 (PN-1) . Positive_regulation PLAT IL1B 1481722 208211 *stimulated* uPA and [tPA] activity . Positive_regulation PLAT IL1B 8826848 385272 Tumour necrosis factor alpha (TNF-alpha) and *increased* in several , but not all , cell lines the production of urokinase-type plasminogen activator ( uPA ) , [tissue-type PA (tPA)] and plasminogen activator inhibitor type 1 ( PAI-1 ) as analysed by zymography , enzyme immunoassays and Northern analysis . Positive_regulation PLAT IL1B 8874752 389999 We found that *increased* [tPA] secretion in these cells . Positive_regulation PLAT IL4 9124280 419504 IFN-gamma decreased the plus bFGF *induction* of both [tPA] and UPA antigens . Positive_regulation PLAT IL6 12794725 1098330 These results suggest that can *regulate* DV-induced [tPA] production of endothelial cells , which may play important roles in the pathogenic development of DHF/DSS . Positive_regulation PLAT IL9 8454185 215280 Nonidet ( 0.01 % ) , sonication , and freezing and thawing of the cells substantially *increased* the stimulatory effect of mycoplasma on [tPA] activity . Positive_regulation PLAT INS 1576255 187321 also *stimulated* uPa and [tPa] production by prepubertal Sertoli cells , and retinol significantly suppressed uPa production and the ability of FSH to stimulate tPa production by midpubertal Sertoli cells . Positive_regulation PLAT JUN 18982462 2006584 We have analyzed a possible *role* of mitogen activated protein kinase (MAPK) and in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Positive_regulation PLAT JUN 18982462 2006611 We further examined whether located in the tPA promoter is *involved* in FSH regulated [tPA] production , and demonstrated that FSH significantly stimulated AP-1 expression , whereas inclusion of H89 , UO126 , or SB20358 in the culture significantly decreased FSH induced AP-1 expression . Positive_regulation PLAT JUN 8013074 262258 This agent selectively *inhibits* the transcription of [tissue-type plasminogen activator] and interstitial collagenase , probably by decreasing the binding of to phorbol ester-responsive elements in the promoters of these genes . Positive_regulation PLAT KLKB1 3908315 54385 Neither nor the labile , human extrinsic [tissue-type plasminogen activator] *induced* activation . Positive_regulation PLAT KRAS 11437413 832806 Surprisingly , low-dose *enhanced* the activity of [tissue-type plasminogen activator] ( tPA ) , and activated pro-matrix metalloproteinases ( proMMP2 and proMMP9 ) . Positive_regulation PLAT KRT18 11689350 876193 tPA binding to K18 may be important in the mechanism whereby complexes *promote* plasminogen activation by [tPA] . Positive_regulation PLAT KRT8 8810346 383319 Cell-surface is the major plasminogen receptor on breast cancer cells and is *required* for the accelerated activation of cell associated plasminogen by [tissue-type plasminogen activator] . Positive_regulation PLAT LEO1 12241114 989687 *stimulated* [tPA] release into the conditioned medium . Positive_regulation PLAT LEO1 1521562 196961 Using a perfused rat hindleg system , release of [tissue-type plasminogen activator (t-PA)] from endothelial cells could be *induced* by , bradykinin , substance P , thrombin , carbachol and A23187 , while this release was inhibited by mepacrine and by nor-dihydroguaiaretic acid . Positive_regulation PLAT LEO1 1719289 169610 The effect of BL 194 on *induced* release of [tPA] and vWF could be mimicked by isobutyl-methylxanthine ( IBMX ) , an inhibitor of phosphodiesterases . Positive_regulation PLAT LEO1 1719289 169615 In vivo , BL 194 and pentoxifylline did not affect baseline levels of plasma tPA and PA inhibitor activity , nor did these compounds affect the in vivo *induction* of [tPA] release by . Positive_regulation PLAT LEO1 3924144 49104 *induced* release of [tissue-type plasminogen activator] from vessel walls . Positive_regulation PLAT LEP 20051227 2200937 In conclusion , our study shows that upregulates the expression of PAI-1 in vascular endothelial cells via activation of ERK1/2 but does not *regulate* [tPA] expression . Positive_regulation PLAT LGALS1 19171142 2049013 moderately *increases* the catalytic activity of [tPA] . Positive_regulation PLAT LGALS1 22162045 2549124 Furthermore , we demonstrated that AnnexinA2 and receptors are *involved* in [tPA] signaling and inflammatory response in glial cells . Positive_regulation PLAT LRP1 18037995 1832674 In rat kidney fibroblasts , [tPA] *induced* rapid tyrosine phosphorylation and enhanced beta1 integrin recruitment by facilitating the LRP-1/beta1 integrin complex formation . Positive_regulation PLAT MAPK1 12387826 1000245 In turn , activation may *cause* [tPA] degradation or a decrease in expression to promote synaptic plasticity . Positive_regulation PLAT MAPK1 15625301 1362092 In a mouse model of focal cerebral ischemia , [tPA] *induces* eNOS inhibition , activation , and p38 inhibition , possibly as part of a more complex signaling response exacerbating brain injury . Positive_regulation PLAT MAPK1 18982462 2006544 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Positive_regulation PLAT MAPK1 18982462 2006585 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Positive_regulation PLAT MAPK10 12387826 1000246 In turn , activation may *cause* [tPA] degradation or a decrease in expression to promote synaptic plasticity . Positive_regulation PLAT MAPK10 18982462 2006545 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Positive_regulation PLAT MAPK10 18982462 2006586 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Positive_regulation PLAT MAPK11 12387826 1000247 In turn , activation may *cause* [tPA] degradation or a decrease in expression to promote synaptic plasticity . Positive_regulation PLAT MAPK11 18982462 2006546 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Positive_regulation PLAT MAPK11 18982462 2006587 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Positive_regulation PLAT MAPK12 12387826 1000248 In turn , activation may *cause* [tPA] degradation or a decrease in expression to promote synaptic plasticity . Positive_regulation PLAT MAPK12 18982462 2006547 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Positive_regulation PLAT MAPK12 18982462 2006588 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Positive_regulation PLAT MAPK13 12387826 1000249 In turn , activation may *cause* [tPA] degradation or a decrease in expression to promote synaptic plasticity . Positive_regulation PLAT MAPK13 18982462 2006548 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Positive_regulation PLAT MAPK13 18982462 2006589 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Positive_regulation PLAT MAPK14 12387826 1000250 In turn , activation may *cause* [tPA] degradation or a decrease in expression to promote synaptic plasticity . Positive_regulation PLAT MAPK14 18982462 2006549 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Positive_regulation PLAT MAPK14 18982462 2006590 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Positive_regulation PLAT MAPK15 12387826 1000244 In turn , activation may *cause* [tPA] degradation or a decrease in expression to promote synaptic plasticity . Positive_regulation PLAT MAPK15 18982462 2006543 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Positive_regulation PLAT MAPK15 18982462 2006583 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Positive_regulation PLAT MAPK3 12387826 1000251 In turn , activation may *cause* [tPA] degradation or a decrease in expression to promote synaptic plasticity . Positive_regulation PLAT MAPK3 18982462 2006550 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Positive_regulation PLAT MAPK3 18982462 2006591 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Positive_regulation PLAT MAPK4 12387826 1000252 In turn , activation may *cause* [tPA] degradation or a decrease in expression to promote synaptic plasticity . Positive_regulation PLAT MAPK4 18982462 2006551 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Positive_regulation PLAT MAPK4 18982462 2006592 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Positive_regulation PLAT MAPK6 12387826 1000253 In turn , activation may *cause* [tPA] degradation or a decrease in expression to promote synaptic plasticity . Positive_regulation PLAT MAPK6 18982462 2006552 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Positive_regulation PLAT MAPK6 18982462 2006593 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Positive_regulation PLAT MAPK7 12387826 1000254 In turn , activation may *cause* [tPA] degradation or a decrease in expression to promote synaptic plasticity . Positive_regulation PLAT MAPK7 18982462 2006553 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Positive_regulation PLAT MAPK7 18982462 2006594 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Positive_regulation PLAT MAPK8 12387826 1000255 In turn , activation may *cause* [tPA] degradation or a decrease in expression to promote synaptic plasticity . Positive_regulation PLAT MAPK8 18982462 2006554 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Positive_regulation PLAT MAPK8 18982462 2006595 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Positive_regulation PLAT MAPK9 12387826 1000256 In turn , activation may *cause* [tPA] degradation or a decrease in expression to promote synaptic plasticity . Positive_regulation PLAT MAPK9 18982462 2006555 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Positive_regulation PLAT MAPK9 18982462 2006596 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Positive_regulation PLAT MMP1 21615740 2464396 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Positive_regulation PLAT MMP10 21615740 2464397 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Positive_regulation PLAT MMP11 21615740 2464398 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Positive_regulation PLAT MMP12 21615740 2464399 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Positive_regulation PLAT MMP13 21615740 2464400 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Positive_regulation PLAT MMP14 21615740 2464401 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Positive_regulation PLAT MMP15 21615740 2464402 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Positive_regulation PLAT MMP16 21615740 2464403 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Positive_regulation PLAT MMP17 21615740 2464404 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Positive_regulation PLAT MMP19 21615740 2464405 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Positive_regulation PLAT MMP2 21615740 2464406 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Positive_regulation PLAT MMP20 21615740 2464407 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Positive_regulation PLAT MMP21 21615740 2464394 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Positive_regulation PLAT MMP24 21615740 2464408 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Positive_regulation PLAT MMP25 21615740 2464391 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Positive_regulation PLAT MMP26 21615740 2464392 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Positive_regulation PLAT MMP27 21615740 2464393 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Positive_regulation PLAT MMP28 21615740 2464395 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Positive_regulation PLAT MMP3 21615740 2464409 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Positive_regulation PLAT MMP7 18721140 1968341 ( matrix metalloprotease-7 ) cleaves membrane bound annexin II and *enhances* binding of [tissue-type plasminogen activator] to cancer cell surfaces . Positive_regulation PLAT MMP7 21615740 2464410 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Positive_regulation PLAT MMP8 21615740 2464411 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Positive_regulation PLAT MMP9 11703174 878876 Additionally , [tissue type plasminogen activator] does not *induce* release by monocytes as observed under the action of urokinase . Positive_regulation PLAT MMP9 12438450 1016777 In vitro , [tPA] *induced* gene expression and protein secretion in renal interstitial fibroblasts . Positive_regulation PLAT MMP9 16303771 1511113 This study investigated the mechanism by which [tPA] *induces* gene expression . Positive_regulation PLAT MMP9 21615740 2464412 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Positive_regulation PLAT MSC 20140248 2208116 Collectively , these in vivo and in vitro data suggest that the *mediated* increased activation of [tPA] in astrocytes promotes neurite outgrowth after stroke . Positive_regulation PLAT MSC 21829213 2500478 To probe the mechanisms that underlie *mediated* activation of [tPA] , we investigated the morphogenetic gene , sonic hedgehog (Shh) pathway . Positive_regulation PLAT NRAS 11437413 832807 Surprisingly , low-dose *enhanced* the activity of [tissue-type plasminogen activator] ( tPA ) , and activated pro-matrix metalloproteinases ( proMMP2 and proMMP9 ) . Positive_regulation PLAT NTF4 10215917 608233 Among the other members of the neurotrophin family , and to a lesser extent neurotrophin-3 (NT-3) also *increased* [tPA] mRNA expression , while nerve growth factor (NGF) was devoid of any effect . Positive_regulation PLAT OSM 12090757 960037 *induces* [tissue-type plasminogen activator] and plasminogen activator inhibitor-1 in Calu-1 lung carcinoma cells . Positive_regulation PLAT OSM 12090757 960038 Western blot studies demonstrated that *mediates* a marked increase in secretion of the [tPA] protein . Positive_regulation PLAT OSM 12090757 960040 Inhibitor studies demonstrated that mediated *induction* of [tPA] and PAI-1 mRNAs is largely dependent upon activation of the MEK1/2 pathway . Positive_regulation PLAT OSM 9863709 556137 On a human microvasculature endothelial cell line , did not modify PAI-1 but *induced* an increase in [tPA] secretion . Positive_regulation PLAT PAEP 19656559 2125724 Therefore , the use of liposomes could prolong the circulation lifetimes and longevity effect of liposomes on [tPA] was *increased* by . Positive_regulation PLAT PAF1 12241114 989685 *stimulated* [tPA] release into the conditioned medium . Positive_regulation PLAT PAF1 1521562 196959 Using a perfused rat hindleg system , release of [tissue-type plasminogen activator (t-PA)] from endothelial cells could be *induced* by , bradykinin , substance P , thrombin , carbachol and A23187 , while this release was inhibited by mepacrine and by nor-dihydroguaiaretic acid . Positive_regulation PLAT PAF1 1719289 169608 The effect of BL 194 on *induced* release of [tPA] and vWF could be mimicked by isobutyl-methylxanthine ( IBMX ) , an inhibitor of phosphodiesterases . Positive_regulation PLAT PAF1 1719289 169613 In vivo , BL 194 and pentoxifylline did not affect baseline levels of plasma tPA and PA inhibitor activity , nor did these compounds affect the in vivo *induction* of [tPA] release by . Positive_regulation PLAT PAF1 3924144 49102 *induced* release of [tissue-type plasminogen activator] from vessel walls . Positive_regulation PLAT PDE4D 22245243 2599885 Inhibition of PDE4 and *reduced* expression of [tPA] by HBEC via Epac pathway . Positive_regulation PLAT PDGFC 18568034 1934998 *Activation* of by [tissue plasminogen activator] impairs blood-brain barrier integrity during ischemic stroke . Positive_regulation PLAT PGP 10937800 720805 Tripeptide after single intravenous ( 0.2 , 1.0 and 1.5 mg/kg ) or intranasal ( 0.5 mg/ kg ) administration *increased* ( P < 0.05 ) total fibrinolytic and fibrin depolymerizating ( FDA ) activities , and [tissue plasminogen activator] levels ( t-PA ) , and decreased the plasmin inhibitors (PI) and activated factor XIII ( factor XIIIa ) levels in blood plasma . Positive_regulation PLAT PIK3CA 23562854 2778008 Glucose deprivation induced activation of , p38 and AMPK , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced [tPA] down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation PLAT PIK3R1 23562854 2778009 Glucose deprivation induced activation of , p38 and AMPK , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced [tPA] down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation PLAT PLAU 15703084 1376365 While was localized mainly in the cell cytoplasm , the [tPA] was *detected* mainly on cell surface and in the perivitelline space . Positive_regulation PLAT PLAU 16313928 1526167 The expression of [tPA] increased greatly during the proliferative stage of culture , and expression *increased* throughout the culture period , increasing markedly from the proliferative to the later stages of culture . Positive_regulation PLAT PLAU 17134505 1661452 Absence of uPAR alone or the combined absence of uPAR and [tPA] had no impact on the resolution of centrilobular injury , but the loss of receptor-free significantly *impaired* the clearance of necrotic hepatocytes up to 14 days after CCl4 . Positive_regulation PLAT PLAU 17680802 1873851 Psychostimulants induce both [tPA] and uPA in acute and chronic drug delivery , but cocaine *induces* preferentially , whereas morphine and amphetamine induce preferentially tPA . Positive_regulation PLAT PLAU 18042398 1846621 During the critical 1-2 h delay period required for this synaptic plasticity following a C2 hemisection in mice , uPA and [tPA] mRNAs are rapidly *induced* in C4-5 ventral spinal cord neurons in the ipsilateral phrenic motor nucleus ( PMN ) , as are and tPA protein levels . Positive_regulation PLAT PLAU 1918136 168367 In three of these five cell lines , this process was *mediated* by [tissue-type plasminogen activator (t-PA)] and in the other two cell lines by ( u-PA ) . Positive_regulation PLAT PLD1 15716416 1374105 We now show that overexpression of wild-type PLD1 in cultured neurons promotes tPA release and tPA dependent neurite extension , whereas overexpression of an inactive PLD1 allele or pharmacological inhibition of *inhibits* [tPA] release . Positive_regulation PLAT PLG 10318667 611845 Plg system components affect FCI at 2 different levels : ( 1 ) reduction of [tPA] activity ( tPA gene inactivation ) reduces whereas its augmentation ( PAI-1 gene inactivation ) increases infarct size , and ( 2 ) reduction of activity ( Plg gene inactivation or alpha2-AP injection ) *increases* whereas its augmentation ( alpha2-AP gene inactivation or alpha2-AP neutralization ) reduces infarct size . Positive_regulation PLAT PLG 10333090 614925 A concomitant enhancement of tissue activity *resulted* in significant increases in tissue plasminogen activity antigen and total fibrin/fibrinogen degradation products , and a significant decrease in [tissue plasminogen activator] inhibitor-1 activity . Positive_regulation PLAT PLG 10376931 623520 The *activation* of ubiquitous by urokinase ( u-PA ) and [tissue-type plasminogen activator (t-PA)] , which is associated with various neuropathologies , including multiple sclerosis (MS) , is the key initiator of the activation cascade of the four classes of matrix metalloproteinases ( MMPs ) : collagenases , stromelysins , membrane-type metalloproteinases and gelatinases . Positive_regulation PLAT PLG 10632469 576576 In an in vitro test , bovine intestine dermatan sulfate exhibited stronger effects on stimulation of heparin cofactor II and *activation* of by [tissue plasminogen activator] . Positive_regulation PLAT PLG 10764803 707572 Type 1 activator inhibitor ( PAI-1 ) , the primary *inhibitor* of [tissue-type plasminogen activator (t-PA)] , circulates as a complex with the abundant plasma glycoprotein , vitronectin . Positive_regulation PLAT PLG 10800598 690437 Truncations in this region also have been found to introduce a new , non-enzymatic biological activity into aspartase , the ability to specifically enhance the *activation* of to plasmin by [tissue plasminogen activator] . Positive_regulation PLAT PLG 11112095 757519 Mechanism of enhancement by fucoidan and CNBr-fibrinogen digest of the *activation* of by [tissue plasminogen activator] . Positive_regulation PLAT PLG 11460476 838819 We report on a study that involved intravenous and subcutaneous application of ancrod in healthy subjects in which it was shown that ancrod induces the formation of desAA-fibrin complexes that are partially crosslinked by factor XIII proenzyme , and act as cofactor in [tPA] *induced* activation . Positive_regulation PLAT PLG 11744725 915977 Type 1 activator inhibitor ( PAI-1 ) , the primary *inhibitor* of [tissue-type plasminogen activator (t-PA)] , is found in plasma and platelets . Positive_regulation PLAT PLG 12695744 1081180 The effect of fucoidan , heparin and cyanogen bromide-fibrinogen on the *activation* of human by [tissue plasminogen activator] . Positive_regulation PLAT PLG 12695744 1081184 Earlier studies on the stimulatory effect of fucoidan , heparin , and cyanogen bromide ( CNBr ) -fibrinogen digest on the in-vitro *activation* of glutamic type by [tissue plasminogen activator] , which were performed using subphysiologic ionic strengths of buffers , gave inconsistent results because of the variation in the ionic strengths of the buffers used . Positive_regulation PLAT PLG 12695744 1081186 The double reciprocal plots of the *activation* of glutamic type by [tissue plasminogen activator] in the presence of fucoidan and 6-aminohexanoic acid ( 6-AH ) or heparin and 6-AH showed a four- to six-fold increase in K ( cat ) , while the K ( m ) remained unchanged . Positive_regulation PLAT PLG 12787697 1097036 the aortic matrix degradation in AAA may be partly caused by an *activation* of by [tPA] , but apparently not by uPA , which usually dominates matrix degradation . Positive_regulation PLAT PLG 1338753 209157 The structure basis of the poor fibrin specificity of urokinase ( II ) -- The inhibition of urokinase A chain 149-157 on the fibrin stimulated *activation* of by [tissue type plasminogen activator] . Positive_regulation PLAT PLG 1388168 196359 It is possible that *regulates* the biosynthesis of [tPA] in HUVEC through the signal transduction pathway involving protein kinase . Positive_regulation PLAT PLG 14515195 1147043 Active plasmin is generated by proteolytic *activation* of the zymogen by urokinase-type plasminogen activator ( uPA ) and [tissue-type plasminogen activator] ( tPA ) . Positive_regulation PLAT PLG 14743974 1182086 Studies were conducted on the mechanism of the stimulatory effect of 6-aminohexanoic acid ( 6-AH ) during the in vitro *activation* of human glutamic ( Glu-Plg ) by streptokinase or by [tissue plasminogen activator (t-PA)] and the possible role of the addition of physiological concentrations of NaCl to the buffer solution . Positive_regulation PLAT PLG 15099052 408440 The BBB endothelium also expresses [tissue plasminogen activator (tPA)] , a key protein in fibrinolysis , and its rapid *inhibitor* , activator inhibitor ( PAI-1 ) . Positive_regulation PLAT PLG 15574344 1355674 Active plasmin is generated by proteolytic *activation* of the zymogen by urokinase-type plasminogen activator ( uPA ) and [tissue-type plasminogen activator] ( tPA ) . Positive_regulation PLAT PLG 1636166 194314 The SF-ELISA immunologically measures the concentration of desAA- and desAABB-fibrin while the SF-tPA-test is based on *activation* of by [tissue plasminogen activator (tPA)] in the presence of fibrin ; Positive_regulation PLAT PLG 16489740 1528542 However , [tPA] *activation* of on Hcys fibrin was slower than that of the control . Positive_regulation PLAT PLG 16489759 1528543 Surprisingly , the same peptides also delay fibrinolysis , whether activated by exogenously added plasmin or from the fibrin enhanced stimulation of [tissue plasminogen activator (tPA)] *activation* of . Positive_regulation PLAT PLG 1689060 126669 By inhibiting the inactivation of plasmin by alpha 2AP , RWR interacts synergistically with activators to *increase* the potency ( for 50 % clot lysis ) of urokinase by 80-fold , [tissue plasminogen activator] by 27-fold , and streptokinase by 20-fold . Positive_regulation PLAT PLG 1693270 132748 Moreover , vitronectin was found to inhibit in a dose dependent fashion the fibrin(ogen) induced *activation* of by [tissue plasminogen activator] . Positive_regulation PLAT PLG 1697146 139511 was stable in equine plasma stored up to 1 week at 4 C and up to 5 months at -70 C . Plasminogen in nonacidified equine plasma was not *activated* by urokinase , streptokinase , [tissue plasminogen activator] , or tissue plasminogen activator plus soluble fibrin . Positive_regulation PLAT PLG 1699517 143265 The mechanism of *activation* of human by fibrin bound [tissue-type plasminogen activator (t-PA)] in a plasma environment or in a reconstituted system was characterized . Positive_regulation PLAT PLG 17182930 1662684 The aortic matrix degradation in AAA may be partly caused by an *activation* of by [tPA] , but not by uPA , which usually dominates matrix degradation . Positive_regulation PLAT PLG 17379720 1715312 Strain ST1 of L. crispatus enhanced *activation* of human by the [tissue-type Plg activator (tPA)] , whereas enhancement of the urokinase mediated Plg activation was lower . Positive_regulation PLAT PLG 18180617 1856510 Effect of oversulfated chondroitin-6-sulfate or oversulfated fucoidan in the *activation* of glutamic by [tissue plasminogen activator] : role of lysine and cyanogen bromide-fibrinogen . Positive_regulation PLAT PLG 18180617 1856512 Addition of 28.6 microg/ml oversulfated compound gave a two-fold to four-fold increase in the rate of enhancement of *activation* of glutamic by [tissue plasminogen activator] using 0.05 mol/l Tris buffer ( pH 7.35 ) containing physiological concentrations of NaCl ( 0.9 % ) . Positive_regulation PLAT PLG 18180617 1856514 In the present study , the effect of lysine or cyanogen bromide treated fibrinogen , alone or in combination with the oversulfated compounds , on the *activation* of glutamic by [tissue plasminogen activator] was investigated . Positive_regulation PLAT PLG 18685430 1949246 The result of the in-vitro studies of the *activation* of glutamic by [tissue plasminogen activator (t-PA)] or by high-molecular-weight urokinase using 0.05 mol/l Tris buffer ( pH 7.35 ) containing a physiological concentration of NaCl ( 0.9 % ) showed that 28.6 microg/ml S-2 enhanced the activation by three-fold to four-fold by t-PA or by urokinase , while the same concentrations of N-2 or unfractionated heparin gave less than 30 % enhancement of t-PA and no enhancement of urokinase . Positive_regulation PLAT PLG 1899177 152048 The *activation* of native human ( Glu1-Pg ) by [tissue plasminogen activator] , urinary plasminogen activator ( u-PA ) , and streptokinase is inhibited by the divalent cations Ca2+ , Mg2+ , and Mn2+ . Positive_regulation PLAT PLG 19017261 2016842 *Activation* of by [tissue-type plasminogen activator (t-PA)] is enhanced in the presence of fibrin or at the endothelial cell surface . Positive_regulation PLAT PLG 1905925 161672 Structural requirements of position A alpha-157 in fibrinogen for the fibrin induced rate enhancement of the *activation* of by [tissue-type plasminogen activator] . Positive_regulation PLAT PLG 1905925 161674 The sequence fibrinogen-A alpha- ( 148-160 ) can mimic part of the fibrin induced rate enhancement of the *activation* of by [tissue-type plasminogen activator] . Positive_regulation PLAT PLG 1948823 171269 We measured antigen levels of two kinds of plasminogen activators , [tissue type plasminogen activator (t-PA)] and urokinase type plasminogen activator ( UK ) , as well as their primary *inhibitor* , type-1 activator inhibitor ( PAI-1 ) in the tissue extracts of benign and malignant breast tumors . Positive_regulation PLAT PLG 1969852 130889 Synthesis , purification , and properties of a peptide that enhances the *activation* of human [ Glu1 ] by [tissue plasminogen activator] and retards fibrin polymerization . Positive_regulation PLAT PLG 19809307 2180577 Similar concentration dependent effects of defibrotide were observed when plasmin was generated by [tissue plasminogen activator] or urokinase *activation* of . Positive_regulation PLAT PLG 20440070 2268335 In contrast , tPA induced delayed IPC required the proteolytic activity of [tPA] and was *mediated* by , the NMDA receptor , and PKB phosphorylation . Positive_regulation PLAT PLG 2114043 135611 We conclude that the incorporation of [tissue-type plasminogen activator] into fibrin and the in situ *activation* of enhance local fibrinolysis , thereby increasing the risk of bleeding in patients undergoing open heart surgery . Positive_regulation PLAT PLG 21346556 2411260 The results of in-vitro studies of the *activation* of glutamic ( Glu-Plg ) by [tissue plasminogen activator (t-PA)] using 0.05 mol/l Tris buffer ( pH 7.35 ) containing physiological concentration of NaCl ( 0.9 % ) , showed that oat spelts xylan sulfate and amylopectin sulfate gave a 20-fold enhancement of the activation in a synergistic manner when used in combination with 32.4 mmol/l of lysine . Positive_regulation PLAT PLG 2148848 146885 Effect of fibrin-like stimulators on the *activation* of by [tissue-type plasminogen activator (t-PA)] -- studies with active site mutagenized plasminogen and plasmin resistant t-PA . Positive_regulation PLAT PLG 2174048 145630 The data clearly illustrate that the binding of with fibrin , mainly determined by kringle 5 , is *essential* for effective activation by [tissue-type plasminogen activator] . Positive_regulation PLAT PLG 21976662 2512843 DNA ( 0.1-5.0 µg/ml ) , but not RNA , potentiates the *activation* of Glu- and by [tPA] and uPA by 480- and 70-fold and 10.7- and 17-fold , respectively , via a template mechanism similar to that known for fibrin . Positive_regulation PLAT PLG 22003920 2516453 *Activation* of to plasmin by staphylokinase or [tissue plasminogen activator] decreased in the presence of TPI , whereas TPI was degraded by plasmin . Positive_regulation PLAT PLG 22187433 2549491 A high affinity interaction of with fibrin is not *essential* for efficient activation by [tissue-type plasminogen activator] . Positive_regulation PLAT PLG 22318336 2575927 Herpes simplex virus types 1 ( HSV1 ) and 2 , and cytomegalovirus ( CMV ) purified from various cell lines each accelerated the proteolytic *activation* of to plasmin by [tPA] . Positive_regulation PLAT PLG 23781399 2885127 Infarct size , neurological deficit scores , blood brain barrier ( BBB ) permeability , brain hemorrhage , and expression of endogenous [tissue plasminogen activator (tPA)] and its *inhibitor* , activator inhibitor ( PAI-1 ) were assessed . Positive_regulation PLAT PLG 2437668 72930 The *activation* of a native form of ( Glu-plg ) by [tissue plasminogen activator(t-PA)] was enhanced when the plasma was clotted by the addition of thrombin or thrombin plus Ca++ . Positive_regulation PLAT PLG 2441630 75845 *Activation* of by [tissue-type plasminogen activator] ( tpA ) is potentiated by fibrin . Positive_regulation PLAT PLG 2500878 113903 In human plasma , the *activation* of by [tissue plasminogen activator (t-PA)] is a fibrin localized process which allows the specific dissolution of thrombi . Positive_regulation PLAT PLG 2504719 117048 Anticoagulant low molecular weight heparin does not enhance the *activation* of by [tissue plasminogen activator] . Positive_regulation PLAT PLG 2546631 115444 *Activation* of by [tissue plasminogen activator (t-PA)] was enhanced by hepatocytes in primary culture . Positive_regulation PLAT PLG 2940088 59385 MA-HAL did not influence the *activation* of by [tissue-type plasminogen activator] in the absence of CNBr digested fibrinogen , but abolished the effect of CNBr digested fibrinogen on the Michaelis constant of the reaction . Positive_regulation PLAT PLG 2941084 59602 *Activation* of by [tissue plasminogen activator] on normal and thrombasthenic platelets : effects on surface proteins and platelet aggregation . Positive_regulation PLAT PLG 2943315 61917 Direct analyses of plasminogen activation by polyacrylamide gel electrophoresis demonstrate that heparin increases the *activation* of by both [tPA] and uPA . Positive_regulation PLAT PLG 2974648 101799 Platelets were found to provide a surface for *activation* of by the [tissue-type plasminogen activator (t-PA)] at an optimum concentration and to potentiate the generation of plasmin by the amidolytic method , fibrin lysis time and fibrin plate method . Positive_regulation PLAT PLG 3083529 58632 Effects of fibrin on the enhanced *activation* of by urokinase and [tissue plasminogen activator] : role of cross-link . Positive_regulation PLAT PLG 3087001 59925 The method is based on the principle that fibrin stimulates the *activation* of by [tissue plasminogen activator (t-PA)] . Positive_regulation PLAT PLG 3127307 90463 The *activation* of ( Glu-Pg ) by streptokinase ( SK ) , urokinase ( UK ) and [tissue plasminogen activator (tPA)] is under rigorous control by molecules such as epsilon-aminocaproic acid ( EACA ) , fibrinogen (Fg) , fibrin ( Fn ) and , as we have recently discovered , anions . Positive_regulation PLAT PLG 3137140 95917 Kinetic analyses were made for the *activation* of ( Glu-Plg ) by [tissue plasminogen activator (t-PA)] obtained from various sources . Positive_regulation PLAT PLG 3139399 97370 A factor from endothelium facilitates *activation* of by [tissue plasminogen activator] . Positive_regulation PLAT PLG 3146348 102754 Effectors of the *activation* of human [ Glu1 ] by human [tissue plasminogen activator] . Positive_regulation PLAT PLG 3146348 102756 The *activation* of human [ Glu1 ] [ ( Glu1 ] Pg ) by human recombinant ( rec ) two-chain [tissue plasminogen activator (t-PA)] is inhibited by Cl- , at physiological concentrations , and stimulated by epsilon-aminocaproic acid ( EACA ) , as well as fibrin(ogen) . Positive_regulation PLAT PLG 3937289 55267 The fibrinolysis potentiating substance in the platelets required the presence of both tPA and plasminogen , suggesting that it potentiates the *activation* of by [tPA] . Positive_regulation PLAT PLG 4040660 51064 *Activation* of human by human [tissue-type plasminogen activator (t-PA)] is accelerated in the presence of cyanogen bromide digests of human fibrin(ogen) . Positive_regulation PLAT PLG 6229056 33141 Differences in effects of fibrin(ogen) fragments on the *activation* of <1-glu-plasminogen> and 442-val-plasminogen by [tissue-type plasminogen activator] . Positive_regulation PLAT PLG 6489341 42557 Stabilization of the Michaelis complex between urokinase and plasminogen by formation of a cyclic ternary complex with CNBr-Fg , which has been invoked to explain the dramatic stimulatory effect of CNBr-Fg on the *activation* of by [tissue-type plasminogen activator] , does not appear to play a significant role in the increased activation rate . Positive_regulation PLAT PLG 6538196 35556 Kinetics of the *activation* of by natural and recombinant [tissue-type plasminogen activator] . Positive_regulation PLAT PLG 6538196 35558 The present findings obtained in a homogenous liquid milieu support the previously proposed mechanism of the *activation* of by [tissue-type plasminogen activator] in the presence of fibrin . Positive_regulation PLAT PLG 6539000 38040 The fibrin mediated enhancement of the *activation* of by [tissue-type plasminogen activator] observed with normal fibrin , is strongly decreased with fibrin Dusard , although the binding of tissue-type plasminogen activator to this fibrin is normal . Positive_regulation PLAT PLG 6543039 44411 Binding does however not seem to be the only condition required since it was found that fragment D is a much stronger potentiator of the *activation* of by [tissue-type plasminogen activator] than fragment E although plasminogen binds to both fragment D and fragment E . Positive_regulation PLAT PLG 6543039 44413 Furthermore , fragment E has the same effect on the *activation* of lys-and by [tissue-type plasminogen activator] . Positive_regulation PLAT PLG 7199524 20127 Kinetics of the *activation* of by human [tissue plasminogen activator] . Positive_regulation PLAT PLG 7199524 20129 The kinetics of the *activation* of and Lys-plasminogen (P) by a two-chain form of human [tissue plasminogen activator (A)] were studied in purified systems , and in the presence of fibrinogen ( f ) and of fibrin films ( F ) of increasing size and surface density . Positive_regulation PLAT PLG 7620156 315567 Intravenous administration of IL-1 alpha ( 10 micrograms/kg ) induced the formation of thrombin , as evidenced by the appearance of thrombin-antithrombin III (TAT) complexes into the circulation ( peak levels , 188 +/- 92 ng/mL at 2 hours ) , as well as the activation of fibrinolysis , assessed by circulating plasmin-alpha 2-antiplasmin complexes ( PAP complexes ; peak levels , 0.4 % +/- 0.03 % of fully activated plasma at 1 hour ) , the release of [tissue-type plasminogen activator] ( t-PA ; peak levels , 6 +/- 2 ng/mL at 2 hours ) , and its *inhibitor* , activator inhibitor ( PAI ; peak levels , 724 +/- 246 ng/mL at 4 hours ) . Positive_regulation PLAT PLG 7696314 297290 It is concluded that plasmin substrates containing a lysine residue have a general capacity to enhance plasminogen activation presumably by inducing a conformational change in the native zymogen in a manner similar to 6-aminohexanoate , while the same substrates are inhibitory both on the amidolytic activity of [sc-tPA] and the *activation* of native and by sc-tPA . Positive_regulation PLAT PLG 7711052 298031 The N-linked sugar on plasminogen ( at Asn-288 ) within kringle 3 reduces the rate of the beta- to alpha-conformational change , modulates the transport of plasminogen into the extravascular compartment , decreases plasminogen binding to U937 cells and downregulates the *activation* of by both urokinase and [tissue plasminogen activator] . Positive_regulation PLAT PLG 8052969 267802 Plasminogen activation assays showed that this [tPA-like-PA] could *induce* activation to form plasmin . Positive_regulation PLAT PLG 8128448 242060 As reported in recent literature , heparin stimulated the *activation* of by high molecular weight ( HMW ) and low molecular weight ( LMW ) two-chain urokinase-type plasminogen activator ( u-PA ) and two-chain [tissue-type plasminogen activator (t-PA)] 10- to 17-fold . Positive_regulation PLAT PLG 8187237 256710 Effects of lipoprotein(a) on the binding of to fibrin and its *activation* by fibrin bound [tissue-type plasminogen activator] . Positive_regulation PLAT PLG 8454185 215275 Mycoplasma cells stimulate in vitro *activation* of by purified [tissue-type plasminogen activator] . Positive_regulation PLAT PLG 8454185 215278 Mycoplasma cells markedly enhanced the *activation* of by [tPA] in a concentration- , temperature- and pH-dependent manner . Positive_regulation PLAT PLG 8641739 362878 During both models of hyperinsulinemia , activator inhibitor activity and antigen decreased significantly ( both P < .001 ) , and [tissue plasminogen activator] activity *increased* significantly ( P < . Positive_regulation PLAT PLG 8810346 383320 Cell-surface cytokeratin 8 is the major plasminogen receptor on breast cancer cells and is required for the accelerated *activation* of cell associated by [tissue-type plasminogen activator] . Positive_regulation PLAT PLG 8810346 383324 These studies identify cell-surface CK 8 as a major plasminogen receptor in breast cancer cells and as a required component for the rapid *activation* of cell associated by [tissue-type plasminogen activator] . Positive_regulation PLAT PLG 8872134 389639 Reexamination of the extent of the *activation* of Lys78 by [tissue plasminogen activator] in the presence of polymerized fibrin . Positive_regulation PLAT PLG 9102401 419238 In contrast , native HPRG bound to hydrazide or nickel chelate surfaces strongly stimulated the *activation* of by [tissue plasminogen activator] , but not by urokinase or streptokinase . Positive_regulation PLAT PLG 9141488 428409 Myosin binds both tPA and plasminogen , and enhances *activation* of by [tPA] but not by urokinase-type plasminogen activator ( uPA ) . Positive_regulation PLAT PLG 9152313 431036 Endogenous fibrinolytic activity was assessed by measurement of [tissue plasminogen activator (tPA)] and its naturally occurring *inhibitor* , activator inhibitor ( PAI-1 ) . Positive_regulation PLAT PLG 9264548 449336 *Activation* of covalently intact by [tissue-type plasminogen activator] ( tPA ) is facilitated by a majority of proteins subjected to denaturing conditions . Positive_regulation PLAT PLG 9268198 449775 To investigate whether the endothelium-platelet interactions may be altered by plasminogen activation , cultured human umbilical vein endothelial cells ( ECs ) were treated with [tissue-type plasminogen activator (t-PA)] in the *presence* of , and platelet adhesion to ECs was subsequently measured by using a tapered flow chamber . Positive_regulation PLAT POLDIP2 23562854 2778004 Glucose deprivation induced activation of PI3K-Akt-GSK3ß , and AMPK , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced [tPA] down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation PLAT PRKAA1 23562854 2778010 Glucose deprivation induced activation of PI3K-Akt-GSK3ß , p38 and , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced [tPA] down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation PLAT PRKAA1 23881246 2861364 Mass spectrometry and immunohistochemical studies show that the release of this [tPA] in the synaptic space *induces* activation in the postsynaptic terminal , and an AMPK mediated increase in neuronal uptake of glucose and neuronal adenosine 5 ' ( tetrahydrogen triphosphate ; Positive_regulation PLAT PRKAA1 24200922 2891714 This [tPA] *induces* activation , membrane recruitment of GLUT1 , and GLUT1 mediated glucose uptake in astrocytes and endothelial cells . Positive_regulation PLAT PRKAA2 23562854 2778011 Glucose deprivation induced activation of PI3K-Akt-GSK3ß , p38 and , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced [tPA] down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation PLAT PRKAA2 23881246 2861365 Mass spectrometry and immunohistochemical studies show that the release of this [tPA] in the synaptic space *induces* activation in the postsynaptic terminal , and an AMPK mediated increase in neuronal uptake of glucose and neuronal adenosine 5 ' ( tetrahydrogen triphosphate ; Positive_regulation PLAT PRKAA2 24200922 2891715 This [tPA] *induces* activation , membrane recruitment of GLUT1 , and GLUT1 mediated glucose uptake in astrocytes and endothelial cells . Positive_regulation PLAT PRKAB1 23562854 2778012 Glucose deprivation induced activation of PI3K-Akt-GSK3ß , p38 and , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced [tPA] down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation PLAT PRKAB1 23881246 2861366 Mass spectrometry and immunohistochemical studies show that the release of this [tPA] in the synaptic space *induces* activation in the postsynaptic terminal , and an AMPK mediated increase in neuronal uptake of glucose and neuronal adenosine 5 ' ( tetrahydrogen triphosphate ; Positive_regulation PLAT PRKAB1 24200922 2891716 This [tPA] *induces* activation , membrane recruitment of GLUT1 , and GLUT1 mediated glucose uptake in astrocytes and endothelial cells . Positive_regulation PLAT PRKAB2 23562854 2778013 Glucose deprivation induced activation of PI3K-Akt-GSK3ß , p38 and , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced [tPA] down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation PLAT PRKAB2 23881246 2861367 Mass spectrometry and immunohistochemical studies show that the release of this [tPA] in the synaptic space *induces* activation in the postsynaptic terminal , and an AMPK mediated increase in neuronal uptake of glucose and neuronal adenosine 5 ' ( tetrahydrogen triphosphate ; Positive_regulation PLAT PRKAB2 24200922 2891717 This [tPA] *induces* activation , membrane recruitment of GLUT1 , and GLUT1 mediated glucose uptake in astrocytes and endothelial cells . Positive_regulation PLAT PRKACB 18493852 1965431 To examine PKA involvement in the effects of db-cAMP on MMP-9 and tPA activity , we added the inhibitors , H89 or rp-cAMP , along with db-cAMP , and they *inhibited* db-cAMP mediated changes in [tPA] activity without affecting MMP-9 activity . Positive_regulation PLAT PRKACG 18493852 1965432 To examine PKA involvement in the effects of db-cAMP on MMP-9 and tPA activity , we added the inhibitors , H89 or rp-cAMP , along with db-cAMP , and they *inhibited* db-cAMP mediated changes in [tPA] activity without affecting MMP-9 activity . Positive_regulation PLAT PRKAG1 23562854 2778014 Glucose deprivation induced activation of PI3K-Akt-GSK3ß , p38 and , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced [tPA] down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation PLAT PRKAG1 23881246 2861368 Mass spectrometry and immunohistochemical studies show that the release of this [tPA] in the synaptic space *induces* activation in the postsynaptic terminal , and an AMPK mediated increase in neuronal uptake of glucose and neuronal adenosine 5 ' ( tetrahydrogen triphosphate ; Positive_regulation PLAT PRKAG1 24200922 2891718 This [tPA] *induces* activation , membrane recruitment of GLUT1 , and GLUT1 mediated glucose uptake in astrocytes and endothelial cells . Positive_regulation PLAT PRKAG2 23562854 2778015 Glucose deprivation induced activation of PI3K-Akt-GSK3ß , p38 and , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced [tPA] down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation PLAT PRKAG2 23881246 2861369 Mass spectrometry and immunohistochemical studies show that the release of this [tPA] in the synaptic space *induces* activation in the postsynaptic terminal , and an AMPK mediated increase in neuronal uptake of glucose and neuronal adenosine 5 ' ( tetrahydrogen triphosphate ; Positive_regulation PLAT PRKAG2 24200922 2891719 This [tPA] *induces* activation , membrane recruitment of GLUT1 , and GLUT1 mediated glucose uptake in astrocytes and endothelial cells . Positive_regulation PLAT PRKAR1A 18493852 1965433 To examine PKA involvement in the effects of db-cAMP on MMP-9 and tPA activity , we added the inhibitors , H89 or rp-cAMP , along with db-cAMP , and they *inhibited* db-cAMP mediated changes in [tPA] activity without affecting MMP-9 activity . Positive_regulation PLAT PRKAR1B 18493852 1965434 To examine PKA involvement in the effects of db-cAMP on MMP-9 and tPA activity , we added the inhibitors , H89 or rp-cAMP , along with db-cAMP , and they *inhibited* db-cAMP mediated changes in [tPA] activity without affecting MMP-9 activity . Positive_regulation PLAT PRKAR2A 18493852 1965435 To examine PKA involvement in the effects of db-cAMP on MMP-9 and tPA activity , we added the inhibitors , H89 or rp-cAMP , along with db-cAMP , and they *inhibited* db-cAMP mediated changes in [tPA] activity without affecting MMP-9 activity . Positive_regulation PLAT PRKAR2B 18493852 1965436 To examine PKA involvement in the effects of db-cAMP on MMP-9 and tPA activity , we added the inhibitors , H89 or rp-cAMP , along with db-cAMP , and they *inhibited* db-cAMP mediated changes in [tPA] activity without affecting MMP-9 activity . Positive_regulation PLAT PTH 1796756 176338 Densitometric scanning of the zymograms of the bone extracts indicated that *stimulated* only the production of [tPA] and had no effect on that of uPA . Positive_regulation PLAT PTH 3017447 62078 and prostaglandin E2 , which increase cyclic AMP production in the sarcoma cells , also *increased* [tPA] activity . Positive_regulation PLAT PTH 3017447 62081 Synthetic peptide antagonists of PTH-responsive adenylate cyclase , [ 34Tyr ] -hPTH ( 3-34 ) amide and [ 34Tyr ] -hPTH ( 5-34 ) amide , inhibited the *induced* increase in [tPA] activity over the same concentration range at which they inhibited cyclic AMP production , but the antagonist peptides had no effect on the tPA responses to prostaglandin E2 , calcitonin or 1,25-dihydroxyvitamin D-3 . Positive_regulation PLAT PTH 8079664 270811 also *enhanced* the activity of [tissue-type plasminogen activator] ( PA ) in extracts of metatarsals but not that of urokinase ( which is , however , the main PA present in the mouse fetal metatarsal culture model ) . Positive_regulation PLAT RARA 9247151 446376 9,13-di-cis-Retinoic acid induces the production of [tPA] and *activation* of latent TGF-beta via in a human liver stellate cell line , LI90 . Positive_regulation PLAT RARB 8695801 372855 Stimulation of [tissue-type plasminogen activator] expression by retinoic acid in human endothelial cells *requires* 2 induction . Positive_regulation PLAT RLN1 9606598 508275 Because tissue-type plasminogen activator ( tPA ) might play a role in follicular rupture and because might *increase* [tPA] production , concentrations of tPA and relaxin in manipulated and control follicles were measured at different stages of development . Positive_regulation PLAT RLN2 9606598 508276 Because tissue-type plasminogen activator ( tPA ) might play a role in follicular rupture and because might *increase* [tPA] production , concentrations of tPA and relaxin in manipulated and control follicles were measured at different stages of development . Positive_regulation PLAT RLN3 9606598 508277 Because tissue-type plasminogen activator ( tPA ) might play a role in follicular rupture and because might *increase* [tPA] production , concentrations of tPA and relaxin in manipulated and control follicles were measured at different stages of development . Positive_regulation PLAT RTN4R 9220151 442527 We have previously reported that *increases* the synthesis of [tissue-type plasminogen activator (t-PA)] and decreases plasminogen activator inhibitor-1 ( PAI-1 ) activity in cultured human endothelial cells from different vascular sources . Positive_regulation PLAT S100A1 15257287 1274351 siRNA mediated downregulation of annexin and disruption of the complex by microinjection of peptide competitors *result* in a marked reduction in vWF but not [tPA] secretion , without affecting the appearance of WPbs . Positive_regulation PLAT SERPINB2 3091604 62521 The was inactive towards single-chain urokinase-type plasminogen activator and plasmin , but it *inhibited* two-chain [tissue-type plasminogen activator] with a k below 10 ( 3 ) M-1 s-1 and thrombin with a k of 4 X 10(4) M-1 s-1 in the absence and 2 X 10 ( 5 ) M-1 s-1 in the presence of heparin . Positive_regulation PLAT SERPINB5 21810423 2505346 This study suggests that extracellular *increased* pro and active uPA and [tPA] released by corneal fibroblasts and myofibroblasts on the short time scale of 1-4 h , but by 24 h there was no increase over the levels produced without maspin . Positive_regulation PLAT SERPIND1 10632469 576575 In an in vitro test , bovine intestine dermatan sulfate exhibited stronger effects on stimulation of and *activation* of Glu-plasminogen by [tissue plasminogen activator] . Positive_regulation PLAT SERPINE1 10764803 707571 Type 1 plasminogen activator *inhibitor* ( ) , the primary inhibitor of [tissue-type plasminogen activator (t-PA)] , circulates as a complex with the abundant plasma glycoprotein , vitronectin . Positive_regulation PLAT SERPINE1 10928471 719613 Fluvastatin inhibits basal and stimulated , but *induces* [tissue type plasminogen activator] in cultured human endothelial cells . Positive_regulation PLAT SERPINE1 11220710 787387 Initial levels of and changes in body mass contributed to the fall in PAI-1 ( adj. R2 = 0.18 , p = 0.0016 ) and initial levels of tPA-Ag *contributed* significantly to changes in [tPA-Ag] ( adj. R2 = 0.57 , p < 0.0001 ) . Positive_regulation PLAT SERPINE1 11744725 915976 Type 1 plasminogen activator *inhibitor* ( ) , the primary inhibitor of [tissue-type plasminogen activator (t-PA)] , is found in plasma and platelets . Positive_regulation PLAT SERPINE1 15099052 408439 The BBB endothelium also expresses [tissue plasminogen activator (tPA)] , a key protein in fibrinolysis , and its rapid *inhibitor* , plasminogen activator inhibitor ( ) . Positive_regulation PLAT SERPINE1 1718809 169406 In most patients , the increase in tissue-type plasminogen activator was counterbalanced by the increased levels of , but in a subgroup of patients the change in balance *resulted* in extremely high [tissue-type plasminogen-activator] levels . Positive_regulation PLAT SERPINE1 17215448 1709673 inactivated soluble tPA at equimolar ratios in vitro , but it *had* no effect on the amidolytic or fibrinolytic activity of [RBC/tPA] . Positive_regulation PLAT SERPINE1 17672283 1669061 The results showed similar concentrations of TF , TM and PAI-2 in both groups , while [tPA] increased no significantly and TFPI and *increased* significantly in SPE placentas . Positive_regulation PLAT SERPINE1 1948823 171268 We measured antigen levels of two kinds of plasminogen activators , [tissue type plasminogen activator (t-PA)] and urokinase type plasminogen activator ( UK ) , as well as their primary *inhibitor* , type-1 plasminogen activator inhibitor ( ) in the tissue extracts of benign and malignant breast tumors . Positive_regulation PLAT SERPINE1 21193004 2391313 In contrast , the massive up-regulation of in astrocytes during subchronic and chronic inflammatory conditions , *leads* to decreased [tPA] activity in the later stages of MCAO . Positive_regulation PLAT SERPINE1 23378038 2754804 The activity of [tPA] is *regulated* by an endogenous inhibitor ( PAI-1 ) , which is expressed mainly in astrocytes . Positive_regulation PLAT SERPINE1 23781399 2885126 Infarct size , neurological deficit scores , blood brain barrier ( BBB ) permeability , brain hemorrhage , and expression of endogenous [tissue plasminogen activator (tPA)] and its *inhibitor* , plasminogen activator inhibitor ( ) were assessed . Positive_regulation PLAT SERPINE1 2503591 115240 There was a significant increase of [tPA] with age in both sexes , but *increased* only in women . Positive_regulation PLAT SERPINE1 7947924 277209 TGF-alpha *enhanced* the expression of the [tissue type plasminogen activator (t-PA)] gene , whereas TGF-beta increased the expression of the gene and inhibited that of the t-PA gene . Positive_regulation PLAT SERPINE1 9152313 431035 Endogenous fibrinolytic activity was assessed by measurement of [tissue plasminogen activator (tPA)] and its naturally occurring *inhibitor* , plasminogen activator inhibitor ( ) . Positive_regulation PLAT SERPINE1 9562609 500606 From results obtained with cycloheximide , ongoing protein synthesis was judged to be required for both induction with dexamethasone and PAI-1 suppression with IBMX , but not for the [tPA] *induction* with IBMX . Positive_regulation PLAT SERPINE2 15128599 1279535 In cultures of cells from small follicles , secreted [tPA] levels increased with time of culture for antral but not basal cells , and levels *increased* with time for basal but not antral cells . Positive_regulation PLAT SERPINI1 12070304 955796 These findings indicate that [tPA] acts on a substrate other than plasminogen and that the effects of on seizure progression and neuronal cell survival are *mediated* through the inhibition of tPA . Positive_regulation PLAT SKP1 9430489 482104 The c-kit ligand *upregulates* uPAR expression , and the release of [tPA] from MC . Positive_regulation PLAT STX2 24578379 2929537 In in vitro cell studies , silencing STXBP5 decreased the release of tPA from vascular endothelial cells , whereas silencing *increased* the [tPA] release . Positive_regulation PLAT SYP 23549381 2804114 Marrow stromal cell treatment significantly enhanced functional recovery after ischemia , concurrent with increases of , synapse density , and myelinated axons along the IBZ , and significantly *increased* [tPA] and Shh expression in astrocytes and neurons compared with control . Positive_regulation PLAT TFPI 17672283 1669060 The results showed similar concentrations of TF , TM and PAI-2 in both groups , while [tPA] increased no significantly and and PAI-1 *increased* significantly in SPE placentas . Positive_regulation PLAT TGFA 7508907 244850 Epidermal growth factor (EGF) or ( TGF-alpha ) *stimulated* cell migration , chemotaxis , and the expression of [tissue-type plasminogen activator (t-PA)] in human omental microvascular endothelial ( HOME ) cells . Positive_regulation PLAT TGFB1 10436120 634504 To study the mechanism of this process , we examined the hypothesis that astrocyte regulation of endothelial [tPA] and TM is *mediated* by ( TGF-beta ) . Positive_regulation PLAT TGFB2 10436120 634505 To study the mechanism of this process , we examined the hypothesis that astrocyte regulation of endothelial [tPA] and TM is *mediated* by ( TGF-beta ) . Positive_regulation PLAT TGFB2 8670784 375070 Cell lines derived from intraocular tumors secreted [tissue-type PA (tPA)] , and *stimulated* tPA activity and secretion of cell lines containing epithelioid cells but had no effect on spindle cells . Positive_regulation PLAT TGFB3 10436120 634506 To study the mechanism of this process , we examined the hypothesis that astrocyte regulation of endothelial [tPA] and TM is *mediated* by ( TGF-beta ) . Positive_regulation PLAT THBS1 1531022 180267 also inhibits urokinase plasminogen activator , but more slowly than plasmin , *stimulates* the amidolytic activity of [tissue plasminogen activator] , and has no effect on the amidolytic activity of alpha-thrombin or factor Xa . Positive_regulation PLAT TNF 11814314 892821 We have examined expression of the components of the plasminogen activation system in human astrocytoma U373-MG cells and found that interleukin 1beta (IL-1beta) , tumour necrosis factor alpha ) , interferon gamma (INF-gamma) and epidermal growth factor (EGF) specifically *regulate* the expression of [tissue-type plasminogen activator (t-PA)] , urokinase-type plasminogen activator ( u-PA ) , plasminogen activator inhibitor type 1 ( PAI-1 ) and protease nexin-1 (PN-1) . Positive_regulation PLAT TNF 12692009 1080463 Intra-arterial impairs endothelium dependent vasodilatation and *stimulates* local [tissue plasminogen activator] release in humans . Positive_regulation PLAT TNF 1433370 204612 The release of tissue-type plasminogen activator was preceded by granulocytopenia , which may indicate an association between a proposed *induced* granulocyte-endothelial interaction in vivo and release of [tissue-type plasminogen activator] . Positive_regulation PLAT TNF 15207722 1261665 RT-PCR analysis and gene reporter assays using the human tPA promoter indicated that upregulation of the tPA gene transcription by both Neovastat and TNFalpha was correlated with the phosphorylation of JNK1/2 and of IkappaB and that SP600125 and BAY11-7082 , inhibitors of JNK and IkappaK , respectively , inhibit the increase of [tPA] gene transcription *induced* by Neovastat and . Positive_regulation PLAT TNF 16171572 1457366 *induced* a time and concentration dependent activation of the urokinase type plasminogen activator ( u-PA ) and [tissue type plasminogen activator (t-PA)] activity in A549 cells . Positive_regulation PLAT TNF 16879221 1593925 This study aims at investigating how *regulates* endothelial gene expression of the key fibrinolytic enzyme [tissue-type plasminogen activator (t-PA)] . Positive_regulation PLAT TNF 17974273 1820569 In addition , T3A cells released more tissue factor ( TF ) , [tissue-type plasminogen activator (t-PA)] , plasminogen activator inhibitor ( PAI-1 ) and urine plasminogen activator ( u-PA ) than LSEC in *response* to . Positive_regulation PLAT TNF 21792242 2532311 We present in vitro and in vivo evidence indicating that endogenous tPA and recombinant [tPA] *induce* the expression of neuronal . Positive_regulation PLAT TNF 8826848 385271 and interleukin-1 beta (IL-1 beta) *increased* in several , but not all , cell lines the production of urokinase-type plasminogen activator ( uPA ) , [tissue-type PA (tPA)] and plasminogen activator inhibitor type 1 ( PAI-1 ) as analysed by zymography , enzyme immunoassays and Northern analysis . Positive_regulation PLAT TUBB4B 9783905 540766 adrenergic receptors *mediate* cAMP , [tissue-type plasminogen activator] and transferrin production in rat Sertoli cells . Positive_regulation PLAT UGCG 21412817 2421293 such as hydrocortisone *regulate* the expression of [tPA/PAI-1] in various biological systems in a tissue-specific manner . Positive_regulation PLAT UTP15 11372682 817785 The aim of the present study was to investigate whether ATP and can *induce* acute [tPA] release from the vascular endothelium in vivo . Positive_regulation PLAT UTP18 11372682 817783 The aim of the present study was to investigate whether ATP and can *induce* acute [tPA] release from the vascular endothelium in vivo . Positive_regulation PLAT UTP20 11372682 817781 The aim of the present study was to investigate whether ATP and can *induce* acute [tPA] release from the vascular endothelium in vivo . Positive_regulation PLAT UTP23 11372682 817786 The aim of the present study was to investigate whether ATP and can *induce* acute [tPA] release from the vascular endothelium in vivo . Positive_regulation PLAT UTP3 11372682 817784 The aim of the present study was to investigate whether ATP and can *induce* acute [tPA] release from the vascular endothelium in vivo . Positive_regulation PLAT UTP6 11372682 817782 The aim of the present study was to investigate whether ATP and can *induce* acute [tPA] release from the vascular endothelium in vivo . Positive_regulation PLAT VEGFA 21486955 2417731 Treatment with the competitive peptide inhibits the generation of plasmin and suppresses the *induced* activity of [tPA] under hypoxic conditions . Positive_regulation PLAT VEGFA 9378778 465695 In both BME and BAE cells , antibodies to bFGF also decreased basal levels of cell associated uPA activity , and completely blocked the mediated *increase* in uPA and [tPA] expression observed in parallel cultures incubated with VEGF alone . Positive_regulation PLAT VIP 11870092 918410 When granulosa cells were stimulated within the intact follicle ( i.e. , maintaining the three-dimensional structure and in the presence of the theca cell layers ) , both PACAP and dose-dependently *stimulated* [tPA] . Positive_regulation PLAT WDR61 12241114 989686 *stimulated* [tPA] release into the conditioned medium . Positive_regulation PLAT WDR61 1521562 196960 Using a perfused rat hindleg system , release of [tissue-type plasminogen activator (t-PA)] from endothelial cells could be *induced* by , bradykinin , substance P , thrombin , carbachol and A23187 , while this release was inhibited by mepacrine and by nor-dihydroguaiaretic acid . Positive_regulation PLAT WDR61 1719289 169609 The effect of BL 194 on *induced* release of [tPA] and vWF could be mimicked by isobutyl-methylxanthine ( IBMX ) , an inhibitor of phosphodiesterases . Positive_regulation PLAT WDR61 1719289 169614 In vivo , BL 194 and pentoxifylline did not affect baseline levels of plasma tPA and PA inhibitor activity , nor did these compounds affect the in vivo *induction* of [tPA] release by . Positive_regulation PLAT WDR61 3924144 49103 *induced* release of [tissue-type plasminogen activator] from vessel walls . Positive_regulation PLAU ABCC6 22131991 2515174 Pretreatment with a PPAR-? antagonist reversed these effects , suggesting that *mediates* its effect on cell motility and [uPA] activity through PPAR-? activation . Positive_regulation PLAU ADCY1 3021458 64534 In contrast to LLC-PK1 cells , the mutant did not exhibit production of urokinase-type plasminogen activator ( uPA ) in response to the hormones calcitonin and vasopressin , but produced the expected levels of [uPA] upon *stimulation* by the receptor independent activators forskolin and cholera toxin , as well as by the phosphodiesterase inhibitor isobutylmethylxanthine and the 8-bromo analogue of adenosine cyclic monophosphate , Br8cAMP . Positive_regulation PLAU ADCY10 3021458 64533 In contrast to LLC-PK1 cells , the mutant did not exhibit production of urokinase-type plasminogen activator ( uPA ) in response to the hormones calcitonin and vasopressin , but produced the expected levels of [uPA] upon *stimulation* by the receptor independent activators forskolin and cholera toxin , as well as by the phosphodiesterase inhibitor isobutylmethylxanthine and the 8-bromo analogue of adenosine cyclic monophosphate , Br8cAMP . Positive_regulation PLAU ADCY2 3021458 64535 In contrast to LLC-PK1 cells , the mutant did not exhibit production of urokinase-type plasminogen activator ( uPA ) in response to the hormones calcitonin and vasopressin , but produced the expected levels of [uPA] upon *stimulation* by the receptor independent activators forskolin and cholera toxin , as well as by the phosphodiesterase inhibitor isobutylmethylxanthine and the 8-bromo analogue of adenosine cyclic monophosphate , Br8cAMP . Positive_regulation PLAU ADCY3 3021458 64536 In contrast to LLC-PK1 cells , the mutant did not exhibit production of urokinase-type plasminogen activator ( uPA ) in response to the hormones calcitonin and vasopressin , but produced the expected levels of [uPA] upon *stimulation* by the receptor independent activators forskolin and cholera toxin , as well as by the phosphodiesterase inhibitor isobutylmethylxanthine and the 8-bromo analogue of adenosine cyclic monophosphate , Br8cAMP . Positive_regulation PLAU ADCY4 3021458 64537 In contrast to LLC-PK1 cells , the mutant did not exhibit production of urokinase-type plasminogen activator ( uPA ) in response to the hormones calcitonin and vasopressin , but produced the expected levels of [uPA] upon *stimulation* by the receptor independent activators forskolin and cholera toxin , as well as by the phosphodiesterase inhibitor isobutylmethylxanthine and the 8-bromo analogue of adenosine cyclic monophosphate , Br8cAMP . Positive_regulation PLAU ADCY5 3021458 64538 In contrast to LLC-PK1 cells , the mutant did not exhibit production of urokinase-type plasminogen activator ( uPA ) in response to the hormones calcitonin and vasopressin , but produced the expected levels of [uPA] upon *stimulation* by the receptor independent activators forskolin and cholera toxin , as well as by the phosphodiesterase inhibitor isobutylmethylxanthine and the 8-bromo analogue of adenosine cyclic monophosphate , Br8cAMP . Positive_regulation PLAU ADCY6 3021458 64539 In contrast to LLC-PK1 cells , the mutant did not exhibit production of urokinase-type plasminogen activator ( uPA ) in response to the hormones calcitonin and vasopressin , but produced the expected levels of [uPA] upon *stimulation* by the receptor independent activators forskolin and cholera toxin , as well as by the phosphodiesterase inhibitor isobutylmethylxanthine and the 8-bromo analogue of adenosine cyclic monophosphate , Br8cAMP . Positive_regulation PLAU ADCY7 3021458 64540 In contrast to LLC-PK1 cells , the mutant did not exhibit production of urokinase-type plasminogen activator ( uPA ) in response to the hormones calcitonin and vasopressin , but produced the expected levels of [uPA] upon *stimulation* by the receptor independent activators forskolin and cholera toxin , as well as by the phosphodiesterase inhibitor isobutylmethylxanthine and the 8-bromo analogue of adenosine cyclic monophosphate , Br8cAMP . Positive_regulation PLAU ADCY8 3021458 64541 In contrast to LLC-PK1 cells , the mutant did not exhibit production of urokinase-type plasminogen activator ( uPA ) in response to the hormones calcitonin and vasopressin , but produced the expected levels of [uPA] upon *stimulation* by the receptor independent activators forskolin and cholera toxin , as well as by the phosphodiesterase inhibitor isobutylmethylxanthine and the 8-bromo analogue of adenosine cyclic monophosphate , Br8cAMP . Positive_regulation PLAU ADCY9 3021458 64542 In contrast to LLC-PK1 cells , the mutant did not exhibit production of urokinase-type plasminogen activator ( uPA ) in response to the hormones calcitonin and vasopressin , but produced the expected levels of [uPA] upon *stimulation* by the receptor independent activators forskolin and cholera toxin , as well as by the phosphodiesterase inhibitor isobutylmethylxanthine and the 8-bromo analogue of adenosine cyclic monophosphate , Br8cAMP . Positive_regulation PLAU ANG 19158252 2043321 Upregulation of *led* to increased activation of [urokinase plasminogen activator] and generation of active plasmin , which facilitated the migration of endothelial cells toward chemoattractants , including angiogenin , and chemotaxis was prevented by the inhibition of angiogenin nuclear translocation . Positive_regulation PLAU ANG 7540839 310143 *up-regulated* both mRNA level and activity of [urokinase type plasminogen activator] , a key mediator of angiogenesis . Positive_regulation PLAU ANGPT2 11280779 798805 MMP-1 , MMP-9 , and [urokinase-type plasminogen activator] in ECs were strongly *up-regulated* by in the presence of VEGF in vitro . Positive_regulation PLAU ANXA5 16638992 1552957 also *increased* the release of [uPA] both from wounded RCE cell monolayers and from nonwounded semiconfluent RCE cells . Positive_regulation PLAU APOB 12167592 973170 In summary , *regulates* PAI-1 , [uPA] , and tPA in biphasic patterns in HMC , and the upregulation of PAI-1 , uPA , and tPA after long-term LDL exposure seems to be mediated by a delayed PKC activation associated with an increased PA inhibitory activity . Positive_regulation PLAU APOB 15149885 1248452 Activation of PAF receptor by oxidised in human monocytes *stimulates* chemokine releases but not [urokinase-type plasminogen activator] expression . Positive_regulation PLAU APOB 15149885 1248453 [uPA] monocyte expression was *stimulated* by either copper ions oxidised or O2*-/HO* free radical oxidised . Positive_regulation PLAU APOB 22906080 2678027 Aggregated low-density *induce* impairment of the cytoskeleton dynamics through [urokinase-type plasminogen activator/urokinase-type] plasminogen activator receptor in human vascular smooth muscle cell . Positive_regulation PLAU ASGR1 12152683 971409 In order to study the *role* of the in the rapid plasma clearance of [urokinase-type plasminogen activator] ( u-PA ) , a microtiter plate binding assay was developed using ASGPr purified from rat liver extracts . Positive_regulation PLAU ASGR2 12152683 971410 In order to study the *role* of the in the rapid plasma clearance of [urokinase-type plasminogen activator] ( u-PA ) , a microtiter plate binding assay was developed using ASGPr purified from rat liver extracts . Positive_regulation PLAU AVPR2 8380270 210126 Oxytocin induced cAMP dependent protein kinase activation and [urokinase-type plasminogen activator] production in LLC-PK1 renal epithelial cells is *mediated* by the . Positive_regulation PLAU BCL10 19097687 2042007 This study demonstrates that additionally *induces* [uPA] expression and FAK activation . Positive_regulation PLAU BCL2 19097687 2042008 This study demonstrates that additionally *induces* [uPA] expression and FAK activation . Positive_regulation PLAU BCL3 19097687 2042009 This study demonstrates that additionally *induces* [uPA] expression and FAK activation . Positive_regulation PLAU BCL5 19097687 2042004 This study demonstrates that additionally *induces* [uPA] expression and FAK activation . Positive_regulation PLAU BCL6 19097687 2042005 This study demonstrates that additionally *induces* [uPA] expression and FAK activation . Positive_regulation PLAU BCL9 19097687 2042006 This study demonstrates that additionally *induces* [uPA] expression and FAK activation . Positive_regulation PLAU BDNF 16620701 1551315 *increased* [uPA] and PAI-1 production in a dose dependent manner . Positive_regulation PLAU BDNF 16620701 1551319 Maximal activation of [uPA] and PAI-1 expression in HUVECs was induced by 100 ng/ml BDNF , while effects of 200 ng/ml and 400 ng/ml BDNF were slightly reduced in comparison with with those of 100 ng/ml. uPAease activity for BDNF was also *increased* by in a dose dependent manner . Positive_regulation PLAU BRAF 22702340 2681744 In PTC , ( V600E ) *induces* [uPA] and uPAR expression . Positive_regulation PLAU BRMS1L 19165610 2038431 Further , we confirm that BRMS1 expression does not alter IKKbeta kinase activity suggesting that *dependent* [uPA] regulation does not occur through inhibition of the classical upstream activators of NF-kappaB . Positive_regulation PLAU BSG 17210677 1681414 Enhanced expression in a tumorigenic breast epithelial cell line NS2T2A *increased* the levels of [uPA] , uPA receptor , and the uPA inhibitor plasminogen activator inhibitor-1 ( PAI-1 ) , as measured by quantitative reverse transcription-PCR , Western blot , and plasminogen-casein zymography . Positive_regulation PLAU BSG 22443116 2588403 In this study , the *role* of in regulating [uPA] and invasion was investigated in oral squamous cell carcinoma ( OSCC ) progression . Positive_regulation PLAU CALCA 11820789 908830 *Induction* of [uPA] but not NF-IL3A by is dependent on Erk1/2 phosphorylation in porcine renal cell line LLC-PK1 . Positive_regulation PLAU CALCA 16381004 1533342 *stimulates* the secretion of [urokinase-type plasminogen activator] from prostate cancer cells : its possible implications on tumor cell invasion . Positive_regulation PLAU CALCA 3021458 64532 In contrast to LLC-PK1 cells , the mutant did not exhibit production of [urokinase-type plasminogen activator] ( uPA ) in *response* to the hormones and vasopressin , but produced the expected levels of uPA upon stimulation by the receptor independent adenylate cyclase activators forskolin and cholera toxin , as well as by the phosphodiesterase inhibitor isobutylmethylxanthine and the 8-bromo analogue of adenosine cyclic monophosphate , Br8cAMP . Positive_regulation PLAU CALCA 3360780 92182 Furthermore , *induction* of [uPA] mRNA accumulation by or 8-bromo-cAMP treatment did not require protein synthesis . Positive_regulation PLAU CALCA 3593259 75415 Inhibition of protein synthesis led to two superinductive effects : an increase in *induced* [uPA] mRNA accumulation over time , and a shift in the dose-response curve so that lower calcitonin doses became more potent . Positive_regulation PLAU CALCA 3593259 75416 To explain these two superinductive effects of protein-synthesis inhibition on calcitonin treatment , we demonstrated that the inhibition of protein synthesis increased both *induced* [uPA-gene] transcription and uPA-mRNA stability . Positive_regulation PLAU CALCA 3653259 78375 T47D cells , however , failed to produce [uPA] in *response* to , forskolin , or the cAMP analog 8-bromo-cAMP , whereas LLC-PK1 cells produced high levels of uPA in response to all these agents . Positive_regulation PLAU CALCA 3827925 70903 Treatment with the synthetic glucocorticoid hormone , dexamethasone , was found to inhibit *induction* of [uPA] enzyme activity by as much as 80 % . Positive_regulation PLAU CASP1 18938165 2000917 We then showed that Egr-1 was necessary early in the fibrotic process for *mediated* apoptosis of myofibroblasts and the production of [urokinase plasminogen activator] , a protein that enhances TGF-beta1 activation . Positive_regulation PLAU CASP10 18938165 2000918 We then showed that Egr-1 was necessary early in the fibrotic process for *mediated* apoptosis of myofibroblasts and the production of [urokinase plasminogen activator] , a protein that enhances TGF-beta1 activation . Positive_regulation PLAU CASP12 18938165 2000928 We then showed that Egr-1 was necessary early in the fibrotic process for *mediated* apoptosis of myofibroblasts and the production of [urokinase plasminogen activator] , a protein that enhances TGF-beta1 activation . Positive_regulation PLAU CASP14 18938165 2000919 We then showed that Egr-1 was necessary early in the fibrotic process for *mediated* apoptosis of myofibroblasts and the production of [urokinase plasminogen activator] , a protein that enhances TGF-beta1 activation . Positive_regulation PLAU CASP16 18938165 2000929 We then showed that Egr-1 was necessary early in the fibrotic process for *mediated* apoptosis of myofibroblasts and the production of [urokinase plasminogen activator] , a protein that enhances TGF-beta1 activation . Positive_regulation PLAU CASP2 18938165 2000920 We then showed that Egr-1 was necessary early in the fibrotic process for *mediated* apoptosis of myofibroblasts and the production of [urokinase plasminogen activator] , a protein that enhances TGF-beta1 activation . Positive_regulation PLAU CASP3 18938165 2000921 We then showed that Egr-1 was necessary early in the fibrotic process for *mediated* apoptosis of myofibroblasts and the production of [urokinase plasminogen activator] , a protein that enhances TGF-beta1 activation . Positive_regulation PLAU CASP4 18938165 2000922 We then showed that Egr-1 was necessary early in the fibrotic process for *mediated* apoptosis of myofibroblasts and the production of [urokinase plasminogen activator] , a protein that enhances TGF-beta1 activation . Positive_regulation PLAU CASP5 18938165 2000923 We then showed that Egr-1 was necessary early in the fibrotic process for *mediated* apoptosis of myofibroblasts and the production of [urokinase plasminogen activator] , a protein that enhances TGF-beta1 activation . Positive_regulation PLAU CASP6 18938165 2000924 We then showed that Egr-1 was necessary early in the fibrotic process for *mediated* apoptosis of myofibroblasts and the production of [urokinase plasminogen activator] , a protein that enhances TGF-beta1 activation . Positive_regulation PLAU CASP7 18938165 2000925 We then showed that Egr-1 was necessary early in the fibrotic process for *mediated* apoptosis of myofibroblasts and the production of [urokinase plasminogen activator] , a protein that enhances TGF-beta1 activation . Positive_regulation PLAU CASP8 18938165 2000926 We then showed that Egr-1 was necessary early in the fibrotic process for *mediated* apoptosis of myofibroblasts and the production of [urokinase plasminogen activator] , a protein that enhances TGF-beta1 activation . Positive_regulation PLAU CASP9 18938165 2000927 We then showed that Egr-1 was necessary early in the fibrotic process for *mediated* apoptosis of myofibroblasts and the production of [urokinase plasminogen activator] , a protein that enhances TGF-beta1 activation . Positive_regulation PLAU CAV1 15769846 1384303 *mediates* the expression and localization of cathepsin B , [pro-urokinase plasminogen activator] and their cell-surface receptors in human colorectal carcinoma cells . Positive_regulation PLAU CBX8 9455804 484480 Moreover , [HMW-uPA] *induces* cell proliferation in LNCaP cells , which do not produce uPA in the basal conditions , while and DU145 cell growth is supported by autocrine production of uPA . Positive_regulation PLAU CCNC 8814143 383465 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU CCND1 9314544 455535 Hox D3 antisense *blocked* the ability of bFGF to induce [uPA] and integrin alphavbeta3 expression , yet had no effect on EC cell proliferation or bFGF mediated expression . Positive_regulation PLAU CD44 12402308 1009508 stimulation by fragmented hyaluronic acid *induces* upregulation of [urokinase-type plasminogen activator] and its receptor and subsequently facilitates invasion of human chondrosarcoma cells . Positive_regulation PLAU CD44 12402308 1009513 Our study indicates that ( i ) stimulation by fragmented HA *upregulates* expression of [uPA] and uPAR mRNA and protein but does not affect MMPs secretion or PAI-1 mRNA expression ; Positive_regulation PLAU CDC73 15149885 1248447 Activation of receptor by oxidised LDL in human monocytes *stimulates* chemokine releases but not [urokinase-type plasminogen activator] expression . Positive_regulation PLAU CDC73 15149885 1248466 Our results indicated that oxidation products are responsible for the monocyte chemokine releases , but did not *contribute* to the enhanced monocyte [uPA] expression by oxidised LDL . Positive_regulation PLAU CDC73 9185044 436693 We have found that in the cornea , a potent lipid inflammatory mediator *activates* the expression of two metalloproteinases ( MMP-1 and MMP-9 ) as well as [urokinase-plasminogen activator (uPA)] . Positive_regulation PLAU CDK19 8814143 383470 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU CDK8 8814143 383468 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU CGA 10457348 639293 Estradiol and insulin did not alter , whereas human chorionic and prolactin *increased* [uPA] activity . Positive_regulation PLAU CGA 11967205 933111 surge *induced* up-regulation of the plasminogen activators ( tissue plasminogen activator and urokinase plasminogen activator ) and the [urokinase plasminogen activator] receptor within bovine periovulatory follicular and luteal tissue . Positive_regulation PLAU CGB8 10457348 639292 Estradiol and insulin did not alter , whereas human chorionic and prolactin *increased* [uPA] activity . Positive_regulation PLAU CGB8 11967205 933110 surge *induced* up-regulation of the plasminogen activators ( tissue plasminogen activator and urokinase plasminogen activator ) and the [urokinase plasminogen activator] receptor within bovine periovulatory follicular and luteal tissue . Positive_regulation PLAU COL1A1 10791952 714409 Bead immobilized laminin-5 and , two major alpha ( 3 ) beta ( 1 ) ligands , also *induced* [uPA] expression . Positive_regulation PLAU COL1A2 10791952 714410 Bead immobilized laminin-5 and , two major alpha ( 3 ) beta ( 1 ) ligands , also *induced* [uPA] expression . Positive_regulation PLAU CSF1 10727433 677898 Macrophage colony stimulating factor ( ) binds to a receptor ( CSF-1R ) encoded by the c-fms proto-oncogene and *activates* transcription of the [urokinase plasminogen activator (uPA)] gene in murine bone-marrow derived macrophages . Positive_regulation PLAU CSF1 10727433 677900 Mutation of the expressed CSF-1R at either Y807 or Y559 , sites of receptor tyrosine phosphorylation implicated in signal transduction , reduced but did not abolish [uPA] promoter *activation* by . Positive_regulation PLAU CSF1 7882368 298849 Furthermore , cell surface bound [uPA] increased from 74 % in the absence of CSF-1 to 100 % ( fully saturated ) in the *presence* of . Positive_regulation PLAU CSF2 10727433 677899 Macrophage ( CSF-1 ) binds to a receptor ( CSF-1R ) encoded by the c-fms proto-oncogene and *activates* transcription of the [urokinase plasminogen activator (uPA)] gene in murine bone-marrow derived macrophages . Positive_regulation PLAU CSF2 1846764 153350 Purified hematopoietic growth factors such as colony stimulating factor-1 (CSF-1) or macrophage CSF , granulocyte-macrophage CSF , and interleukin-3 or , *stimulate* the [urokinase-type plasminogen activator] ( u-PA ) activity of murine bone marrow derived macrophages ( BMM ) and resident peritoneal macrophages . Positive_regulation PLAU CSF2 1899623 153922 Activation of human monocytes by granulocyte-macrophage : *increased* [urokinase-type plasminogen activator] activity . Positive_regulation PLAU CSF2 7684044 216602 When examined at similar concentrations , bFGF had little effect , and interleukin-1 alpha , tumor necrosis factor-alpha , and monocyte *had* no effect on macrophage [uPA] expression . Positive_regulation PLAU CSF3 16331631 1526315 3 ) primary and metastatic tumors significantly upregulated uPA and PAI-1 expression in Bik-/- mice relative to Bik+/+ mice at least through phosphorylation of ERK1/2 and 4 ) exogenous bikunin suppressed phosphorylation of ERK1/2 and upregulation of [uPA] and PAI-1 expression in 3LL cells in *response* to . Positive_regulation PLAU CSF3 9872602 556918 We showed that *induced* a dose dependent increase in the [urokinase-type plasminogen activator] ( uPA ) activity in the conditioned medium of a PC-9 lung cancer cell line . Positive_regulation PLAU CTNNB1 12958170 1138186 Here we provide evidence that PGE2 transactivates c-Met-R ( contingent upon functional EGFR ) , increases tyrosine phosphorylation and nuclear accumulation of , and *induces* [urokinase-type plasminogen activator] receptor ( uPAR ) mRNA expression . Positive_regulation PLAU CTNNB1 15004225 1237027 Our results show that low concentrations of DCA ( 5 and 50 microM ) significantly increase tyrosine phosphorylation of , *induce* [urokinase-type plasminogen activator] , uPAR , and cyclin D1 expression and enhance colon cancer cell proliferation and invasiveness . Positive_regulation PLAU CTNNB1 20624392 2297147 However , [uPA-PAI-1] complex , *increased* type II VLDLR expression with promoted cell proliferation and migration and stabilization of . Positive_regulation PLAU CTR9 15149885 1248448 Activation of receptor by oxidised LDL in human monocytes *stimulates* chemokine releases but not [urokinase-type plasminogen activator] expression . Positive_regulation PLAU CTR9 15149885 1248467 Our results indicated that oxidation products are responsible for the monocyte chemokine releases , but did not *contribute* to the enhanced monocyte [uPA] expression by oxidised LDL . Positive_regulation PLAU CTR9 9185044 436694 We have found that in the cornea , a potent lipid inflammatory mediator *activates* the expression of two metalloproteinases ( MMP-1 and MMP-9 ) as well as [urokinase-plasminogen activator (uPA)] . Positive_regulation PLAU CTSB 10708859 673624 can degrade extracellular matrix proteins , such as collagen IV and laminin , and can *activate* the precursor form of [urokinase plasminogen activator (uPA)] , perhaps thereby initiating an extracellular proteolytic cascade . Positive_regulation PLAU CTSB 11815600 928872 In the absence of TPA , exogenously added *activated* [pro-uPA] and suppressed MCF10A-Neo proliferation . Positive_regulation PLAU CTSB 11815600 928874 Pretreatment with cycloheximide did not suppress the exocytosis of or the *activation* of [pro-uPA] . Positive_regulation PLAU CTSB 1900515 153994 efficiently *activates* the soluble and the tumor cell receptor bound form of the proenzyme [urokinase-type plasminogen activator] ( Pro-uPA ) . Positive_regulation PLAU CTSC 8055919 267893 *Activation* of thrombin inactivated single-chain [urokinase-type plasminogen activator] by ( cathepsin C ) . Positive_regulation PLAU CTSD 1900515 153996 In contrast , no significant *activation* of [pro-uPA] by was observed . Positive_regulation PLAU CTSL 1551416 184055 Enzymatic assays , SDS-PAGE and Western blot analysis revealed that is a potent *activator* of [pro-uPA] . Positive_regulation PLAU CTSL 1551416 184057 As determined by N-terminal amino acid sequence analysis , *activation* of [pro-uPA] by is achieved by cleavage of the Lys158-Ile159 peptide bond , a common activation site of serine proteases such as plasmin and kallikrein . Positive_regulation PLAU CTSL 1551416 184058 Nevertheless , even at pH 7.0 , [pro-uPA] was *activated* by , although a 10-fold higher concentration of cathepsin L was required . Positive_regulation PLAU CXCL12 21567400 2562267 receptor 4 and ß1 integrin interaction *regulates* [urokinase-type plasminogen activator] expression in human colorectal cancer cells . Positive_regulation PLAU CXCL12 21567400 2562269 We found that stimulation *led* to an increase in the expression and secretion of [uPA] in these cells . Positive_regulation PLAU CXCL12 21567400 2562270 Experiments involving specific inhibitors and small interfering RNA demonstrated that the activation of p38 mitogen activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/Akt pathways are critical for *induced* [uPA] expression . Positive_regulation PLAU CXCL12 21567400 2562273 Inhibition of Sp1 and AP-1 activation blocked the *induced* expression and activity of the [uPA] promoter . Positive_regulation PLAU DNLZ 8908197 394502 We now report that or S180 cell conditioned medium rapidly induces a 4- to 5-fold *increase* in cell bound [uPA] activity and in the high-affinity binding of 125I-prouPA to vascular endothelial cells . Positive_regulation PLAU E2F1 10688648 670074 We found that overexpression of , which acts mainly in late G ( 1 ) , *inhibits* promoter activity and endogenous expression of the [urokinase-type PA (uPA)] and PA inhibitor 1 (PAI-1) genes . Positive_regulation PLAU EGF 10377062 623530 The [uPA] activity in oocytes was not *detected* when they were cultured without cumulus cells in either the presence or absence of EGF , although cumulus expansion was stimulated by , exhibiting a time-course similar to that observed in PA production . Positive_regulation PLAU EGF 11814314 892826 We have examined expression of the components of the plasminogen activation system in human astrocytoma U373-MG cells and found that interleukin 1beta (IL-1beta) , tumour necrosis factor alpha TNF-alpha ) , interferon gamma (INF-gamma) and specifically *regulate* the expression of tissue-type plasminogen activator (t-PA) , [urokinase-type plasminogen activator] ( u-PA ) , plasminogen activator inhibitor type 1 ( PAI-1 ) and protease nexin-1 (PN-1) . Positive_regulation PLAU EGF 12384986 999493 also *induced* increased expression of [uPA] and uPA receptor (uPAR) proteins and mRNA , as well as transcription factor activator protein-1 (AP-1)-DNA binding . Positive_regulation PLAU EGF 12384986 999494 Moreover , transfection of SCC cells with AP-1 decoy oligodeoxynucleotides ( ODNs ) resulted in the suppression of *induced* [uPA] and uPAR expression and Matrigel invasion . Positive_regulation PLAU EGF 12841683 1108335 *increased* [uPA] protein level and uPA activity in both cell types . Positive_regulation PLAU EGF 14699120 1211596 DN Lck and inhibitors of Lck , receptor , and MEK-1 *suppressed* H/R induced [uPA] secretion and cell motility . Positive_regulation PLAU EGF 15886816 1406884 ( 6 ) the *induced* [uPA] secretion and its membrane uptake through the increment of uPAR ; Positive_regulation PLAU EGF 16340751 1504030 Subsequently , the *induced* MMP-9 and [uPA] expression and MMP-9 activity , as well as cell invasiveness , were also inhibited by these NF-kappaB inhibitors . Positive_regulation PLAU EGF 18478929 1840486 Subsequently , the *induced* [uPA] expression and invasiveness were also inhibited by NF-kappaB inhibitor . Positive_regulation PLAU EGF 18824345 2113760 ISL decreased *induced* secretion of [urokinase-type plasminogen activator] ( uPA ) , matrix metalloproteinase (MMP)-9 , tissue inhibitor of metalloproteinase-1 ( TIMP-1 ) , and vascular endothelial growth factor ( VEGF ) , but increased TIMP-2 secretion in a concentration dependent manner . Positive_regulation PLAU EGF 18824345 2113764 The JNK inhibitor SP600125 inhibited basal and *induced* secretion of [uPA] , VEGF , MMP-9 and TIMP-1 , as well as AP-1 DNA binding activity and cell migration . Positive_regulation PLAU EGF 1904255 159342 At high seeding density , *stimulated* an increase in [urokinase type plasminogen activator] activity , which may have augmented the ability of cells to degrade the extracellular matrix . Positive_regulation PLAU EGF 20467333 2268920 Here , we characterized the signal transduction pathway ( s ) by which *regulates* [uPA] expression and promotes astrocytoma invasion . Positive_regulation PLAU EGF 20467333 2268935 Similarly , mutations in the activator protein 1 binding site of the uPA promoter reduced *induced* increases in [uPA] promoter activity . Positive_regulation PLAU EGF 20467333 2268936 In summary , these results suggest that c-Src , mitogen activated protein kinase , and a composite activator protein 1 on the uPA promoter are responsible for *induced* [uPA] expression and GBM invasion . Positive_regulation PLAU EGF 2128970 150617 It has previously been reported that *enhances* [uPA] but not tPA in the A431 squamous carcinoma cell line . Positive_regulation PLAU EGF 21303946 2403661 *dependent* induction of matrix metalloproteinase (MMP)-2 , pro- and active form of [urokinase plasminogen activator] , and chorionic gonadotropin ( CG ) -ß was noticed in shRNAmir-control cells , whereas these genes were suppressed in EGF treated shRNAmir-AP-2a cells . Positive_regulation PLAU EGF 22716951 2726332 Maslinic acid significantly ( P < 0·05 ) down-regulated both basal and *stimulated* secretion of matrix metalloproteinase (MMP)-9 ( 25-67 % ) , MMP-2 ( 50-86 % ) , [urokinase-type plasminogen activator] ( uPA , about 100 % ) , vascular endothelial growth factor ( VEGF , 98-100 % ) and tissue inhibitors of metalloproteinases ( TIMP ) -1 , as well as expression of uPA receptor (uPAR) , intercellular adhesion molecules ( 22-33 % ) , vascular cell adhesion molecules ( 23-46 % ) and E-cadherin , whereas it increased TIMP-2 secretion . Positive_regulation PLAU EGF 2497975 111788 Time course studies of the *mediated* induction of [uPA] activity in A431 tumor cells indicated that within 8 h after exposure to EGF , a twofold increase above basal untreated control levels was observed using the substrate hydrolysis assay . Positive_regulation PLAU EGF 7782459 309678 Recent experiments show that both LIF and *stimulate* secretion of [urokinase-type plasminogen activator] ( uPA ) and gelatinase B/matrix metalloproteinase-9 (MMP-9) in day 7 mouse blastocyst outgrowths . Positive_regulation PLAU EGF 8616826 353880 *increased* [uPA] secretion from both cell lines , as determined by ELISA and zymography , and this correlated with increased expression of uPA mRNA . Positive_regulation PLAU EGF 9547511 498798 Finally , *caused* an increase in the steady-state [uPA] mRNA levels in the cells . Positive_regulation PLAU EGF 9547511 498799 These results provide evidence that *causes* an increase in the secretion of [uPA] by rat endometrial stromal cells from uteri sensitized for the decidual cell reaction through a mechanism that involves an increase in steady-state uPA mRNA levels . Positive_regulation PLAU EGF 9639404 514067 Here , we have identified transcriptional requirements for the *induction* of [uPA] and 92 kDa type IV collagenase by . Positive_regulation PLAU EGF 9639404 514072 Reporter transfection assays revealed the *activation* of [uPA] and MMP-9 collagenase promoters by and the requirement of each of the composite Ets and AP-1 transcription factor binding sites for an EGF response . Positive_regulation PLAU EGF 9639404 514074 Most notably , transfections with the Ets-1 and Ets-2 expression vectors potentiated [uPA] and MMP-9 promoter activation in *response* to . Positive_regulation PLAU EGFR 24340014 2880784 Treatment of HPNE/K-Ras/ShSmad4 cells with an inhibitor of EGFR reduced EGF mediated NF-?B nuclear translocation and inhibitors of either or NF-?B *reduced* the increase in MMP-9 or [uPA] expression . Positive_regulation PLAU EGR1 17581316 1764128 STI571 may therefore influence many aspects of tumor cell biology through inducing [urokinase-type plasminogen activator] and interleukin-8 , in which the induction of expression and extracellular signal regulated kinase 1/2 phosphorylation might be *involved* . Positive_regulation PLAU ELAVL1 14517288 1147345 stabilized an ARE ( uPA ) -containing RNA substrate in vitro and *stabilized* in HeLa Tet-off cells both endogenous [uPA] and uPAR mRNAs and a beta-globin reporter mRNA containing the ARE ( uPA ) . Positive_regulation PLAU ELAVL1 14517288 1147347 RNAi mediated depletion of in BT-549 and MDA-MB-231 cells significantly *reduced* the steady-state levels of endogenous [uPA] and uPAR mRNAs . Positive_regulation PLAU ELN 24874477 2945731 We showed that and VGVAPG elastin hexapeptide *stimulated* Hsp90 , pro-MMP-2 and [uPA] secretion within 6 h , whereas AGVPGLGVG and GRKRK peptides had no effect . Positive_regulation PLAU ENPP2 17013094 1629244 *stimulates* [urokinase-type plasminogen activator] expression through phosphoinositide 3-kinase-Akt-nuclear [ corrected ] factor kappa B signaling cascade in human melanoma cells . Positive_regulation PLAU ENPP2 17013094 1629300 *induced* [uPA] expression in a dose dependent manner that was inhibited by pharmacological inhibitors for Gi ( pertussis toxin ) , phosphoinositide 3-kinase ( PI3K , LY294002 ) , Akt inhibitor (AktI) , proteosome activity and IkappaB phosphorylation ( pyrrolidine dithiocarbamate ) , and by a dominant negative mutant ( DN ) of Akt . Positive_regulation PLAU ENPP2 17013094 1629303 Moreover , *increased* the DNA binding ability of NF-kappaB and promoter activity of [uPA] . Positive_regulation PLAU ENPP2 17013094 1629304 Collectively , these data strongly suggest *induces* [uPA] expression via the Gi-PI3K-Akt-NF-kappaB signaling pathway that might be critical for autotaxin induced tumor cell invasion and metastasis . Positive_regulation PLAU EPHB2 11774742 890607 We next asked whether the mechanism of inhibition of uPA expression by bik is due to interference with MAP kinase , since PMA could also activate a signaling pathway involving *dependent* [uPA] expression . Positive_regulation PLAU EPHB2 12458339 1021595 but not phospholipase D is *involved* in keratinocyte growth factor stimulated secretion of matrix metalloprotease-9 and [urokinase-type plasminogen activator] in SNU-16 human stomach cancer cell . Positive_regulation PLAU EPHB2 12458339 1021610 However , only inhibition of Src and could *block* KGF stimulated secretion of [uPA] and MMP-9 . Positive_regulation PLAU EPHB2 14704150 1219069 To our knowledge , this is the first report that OPN induces alpha(v)beta(3) integrin mediated AP-1 activity and uPA secretion by activating c-Src/EGFR/ERK signaling pathways and further demonstrates a functional molecular link between OPN induced integrin/c-Src dependent EGFR phosphorylation and *mediated* [uPA] secretion , and all of these ultimately control the motility of breast cancer cells . Positive_regulation PLAU EPHB2 16520550 1531208 In contrast , SB203580 pre-treatment enhanced cell proliferation and [uPA] secretion *due* to induction of phosphorylation . Positive_regulation PLAU EPHB2 17222183 1689172 *Induction* of [uPA] gene expression by the blockage of E-cadherin via Src- and Shc dependent signaling . Positive_regulation PLAU EPHB2 18495808 1933713 In a 3-D system , we found that not only [uPA-uPAR] association but also the *activation* of were inhibited by HKa . Positive_regulation PLAU EPHB2 20006595 2217442 These results suggest that *mediated* [uPA] activation may be an important factor in cryo-damage of primary uterine cells . Positive_regulation PLAU EPHB2 20491781 2288870 Taken together , these results reveal that 67LR promotes the invasive and metastatic ability of the gastric cancer cells through *increasing* [uPA] and MMP 9 expression , with involvement of the and JNK signal pathway in hypoxia induced 67 LR expressions and subsequent uPA and MMP9 expression . Positive_regulation PLAU ERBB2 12174885 974533 The *up-regulation* of [uPA] by seen in lung cancer cells in vitro is apparently lost in the blood in vivo as is evidenced by the lack of correlation between them which is also true for the receptor as well . Positive_regulation PLAU ERBB2 15247985 1271130 The *upregulation* of [uPA] by seen in cancer cells in vitro appears to occur in vivo in early stage cervical cancer . Positive_regulation PLAU ERBB2 16407820 1560970 Moreover , *mediated* upregulation of [urokinase-type plasminogen activator] receptor ( uPAR ) is reduced by either the PKCalpha inhibitor Go6976 or the Src inhibitor PP2 , and the combination of Go6976 with PP2 is superior to either agent alone in suppressing uPAR expression and cell invasion . Positive_regulation PLAU ERBB2 20043086 2192834 We also demonstrate that the p38 MAPK is an important signaling molecule in the induced *upregulation* of MMP-13 and [uPA] and invasion/migration of H-Ras MCF10A cells overexpressing ErbB2 . Positive_regulation PLAU ERVK-6 10642175 660757 The [pro-uPA] converting activity of the mGK-6 enzyme , as well as its ability to cleave a synthetic substrate for glandular kallikrein , was *inhibited* by the serine proteinase inhibitor leupeptin but not by other serine inhibitors such as aprotinin , antithrombin III , or alpha(1)-antitrypsin . Positive_regulation PLAU ERVK-6 11027463 738931 The following activation mechanism for might occur : [uPA] coexpressed with MMP-9 *activated* plasminogen , and plasmin activated proMMP-3 , which was secreted depending upon inflammatory infiltration , and then MMP-3 activated proMMP-9 , resulting in colorectal cancer progression and metastasis . Positive_regulation PLAU ERVK-6 18460030 1927024 The addition of aprotinin , a serine inhibitor , and tranexamic acid , a [uPA-plasmin] *inhibitor* , inhibited the plasmin induced impairment of BM assembly and facilitated BM reorganization , thereby improving the epidermal structure . Positive_regulation PLAU ETS1 10218628 608487 positively *regulates* expression of [urokinase-type plasminogen activator] ( uPA ) and invasiveness of astrocytic tumors . Positive_regulation PLAU ETS1 18772901 2020436 In addition , expression of the in the pancreatic cancer cells *resulted* in downregulation of [urokinase-type plasminogen activator] ( u-PA ) and metalloproteinase-1 ( MMP-1 ) expression . Positive_regulation PLAU ETV1 12054346 951036 Ectopic expression of the ets transcription factor in transgenic mouse mammary gland *enhances* both [urokinase plasminogen activator] and stromelysin-1 transcription . Positive_regulation PLAU FASLG 15670977 1382183 Stimulation of TRAF2 overexpressing cells with *led* to induction of NF-kappaB and AP-1 , enhanced IL-8- and [uPA-secretion] , and a further increased invasiveness . Positive_regulation PLAU FERMT2 18505917 1917952 Overexpression of increased uPA accumulation at the intracellular face of cell-ECM adhesions and *reduced* the level of secreted [uPA] . Positive_regulation PLAU FGF1 1905574 161584 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Positive_regulation PLAU FGF1 8868466 389226 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Positive_regulation PLAU FGF10 14996996 1220488 VEGF , EGF , FGF-4 and , but not FGF-2 , *stimulate* the activity of trophoblast [uPA] , PAI-1 and MMP-9 . Positive_regulation PLAU FGF10 1905574 161585 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Positive_regulation PLAU FGF10 8868466 389227 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Positive_regulation PLAU FGF11 1905574 161586 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Positive_regulation PLAU FGF11 8868466 389228 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Positive_regulation PLAU FGF12 1905574 161587 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Positive_regulation PLAU FGF12 8868466 389229 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Positive_regulation PLAU FGF13 1905574 161588 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Positive_regulation PLAU FGF13 8868466 389230 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Positive_regulation PLAU FGF14 1905574 161589 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Positive_regulation PLAU FGF14 8868466 389231 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Positive_regulation PLAU FGF16 1905574 161590 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Positive_regulation PLAU FGF16 8868466 389232 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Positive_regulation PLAU FGF17 1905574 161591 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Positive_regulation PLAU FGF17 8868466 389233 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Positive_regulation PLAU FGF18 1905574 161592 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Positive_regulation PLAU FGF18 8868466 389234 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Positive_regulation PLAU FGF19 1905574 161593 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Positive_regulation PLAU FGF19 8868466 389235 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Positive_regulation PLAU FGF2 10393815 627249 Role of endothelial cell extracellular signal regulated kinase1/2 in [urokinase-type plasminogen activator] *upregulation* and in vitro angiogenesis by . Positive_regulation PLAU FGF2 10393815 627251 This is prevented by the MEK inhibitors PD 098059 and U0126 , which also inhibit *mediated* upregulation of [urokinase-type plasminogen activator] ( uPA ) and in vitro formation of capillary-like structures in three-dimensional type I collagen gel . Positive_regulation PLAU FGF2 11500940 847160 ( d ) *induced* [urokinase-type PA (uPA)] in BME and BAE cells , while VEGF induced uPA and tissue-type PA in BME cells with no effect on BAE cells . Positive_regulation PLAU FGF2 12370824 996111 PI3-kinase inhibitors , wortmannin and LY294002 , both enhanced *dependent* [uPA] production by these cells . Positive_regulation PLAU FGF2 12370824 996119 In cells stably expressing mutant p85alpha subunit , efficiently *induced* [uPA] production . Positive_regulation PLAU FGF2 12761886 1091761 In conclusion , these data suggest that genistein , apigenin , and 3-hydroxyflavone inhibit in vitro angiogenesis , in part via preventing *induced* MMP-1 and [uPA] expression and the activation of pro-MMP-2 , and via modulating their inhibitors , TIMP-1 and -2 , and PAI-1 . Positive_regulation PLAU FGF2 12806374 1101685 In PC-3 cells , TGF beta1 and *increased* [urokinase plasminogen activator] secretion . Positive_regulation PLAU FGF2 14996996 1220489 VEGF , EGF , FGF-4 and FGF-10 , but not , *stimulate* the activity of trophoblast [uPA] , PAI-1 and MMP-9 . Positive_regulation PLAU FGF2 15389540 1354277 *mediated* upregulation of [urokinase-type plasminogen activator] expression requires a MAP-kinase dependent activation of poly ( ADP-ribose ) polymerase . Positive_regulation PLAU FGF2 15558021 1361107 Both FGF-2 and phorbol ester-inducible urokinase-type plasminogen activator ( uPA ) expression requires AP-1 binding to an enhancer element in the uPA promoter , and we have previously shown that or PMA *induction* of [uPA] expression is strongly dependent on MEKK1 . Positive_regulation PLAU FGF2 1734031 181659 These results suggest that BAE cell migration from the edge of a wounded monolayer is dependent upon local increases of [uPA] *mediated* by endogenous . Positive_regulation PLAU FGF2 1905574 161594 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Positive_regulation PLAU FGF2 2168862 140382 We have previously shown that the proliferation of cultured astrocytes can be stimulated by the urokinase-type ( uPA ) of plasminogen activator (PA) and that astrocytes are able to release such [uPA] upon *stimulation* with , which is known to act as a mitogen for these cells . Positive_regulation PLAU FGF2 7508907 244852 *stimulated* cell proliferation , cell migration , tubulogenesis and the expression of [urokinase-type plasminogen activator] ( u-PA ) in bovine aortic endothelial ( BAE ) cells . Positive_regulation PLAU FGF2 7513254 253678 Suramin , an anticancer and angiosuppressive agent , inhibits endothelial cell binding of , migration , proliferation , and *induction* of [urokinase-type plasminogen activator] . Positive_regulation PLAU FGF2 7523424 272192 This indicates that both the increase in [uPA] production and formation of capillary-like structures are *mediated* by endogenous expressed by the endothelial cells . Positive_regulation PLAU FGF2 7860647 295257 also induced an *increase* in cell associated [uPA] activity only when added to the cell cultures in the presence of soluble heparin . Positive_regulation PLAU FGF2 8547215 326504 We found that the [uPA] gene is transcriptionally *induced* by as well as by 12-O-tetradecanoylphorbol-13 -acetate involving a PEA3/AP1 element located 2.4 kb upstream of the transcription initiation site ; Positive_regulation PLAU FGF2 8868466 389181 ( FGF-2 ) *induces* cell proliferation and [urokinase-type plasminogen activator] ( uPA ) production in fetal bovine aortic endothelial GM 7373 cells . Positive_regulation PLAU FGF2 8868466 389236 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Positive_regulation PLAU FGF2 8868466 389277 Accordingly , *induces* [uPA] up-regulation in Chinese hamster ovary cells transfected with wild-type FGFR-1 , -2 , -3 , or -4 but not with TK- FGFR-1 mutant . Positive_regulation PLAU FGF2 8868466 389278 [uPA] *up-regulation* by liposome encapsulated was quenched by neutralizing anti-FGF-2 antibodies , indicating that the activity of liposome delivered FGF-2 is mediated by an extracellular action of the growth factor . Positive_regulation PLAU FGF2 8892973 392265 The *induced* increase in [uPA] activity was inhibited in a dose dependent manner by hydrocortisone and transforming growth factor-beta1 ( TGF-beta1 ) . Positive_regulation PLAU FGF2 8940113 398945 *Induction* of [urokinase-type plasminogen activator] by is dependent on expression of FGF receptors and does not require activation of phospholipase Cgamma1 . Positive_regulation PLAU FGF2 8940113 398993 Internalization of FGF through heparan sulfates does not seem to be involved in this response as soluble heparin and suramin at concentrations which inhibited FGF-2 binding to heparan sulfates but not receptors did not affect the *induction* of [uPA] by . Positive_regulation PLAU FGF2 8940113 398994 In contrast , mutation of the site of phospholipase Cgamma1 (PLCgamma) binding in the receptor , which causes loss of PLCgamma activation , had no effect on [uPA] *induction* by . Positive_regulation PLAU FGF2 8940113 398995 These results suggest that PLCgamma activation is not required for *induction* of [uPA] by . Positive_regulation PLAU FGF2 9168787 432634 To investigate the mechanisms by which NO controls angiogenesis , NO was assessed for the ability to affect cell proliferation and upregulation of [urokinase-type plasminogen activator] ( uPA ) *induced* by when added exogenously to or when produced endogenously by coronary venular endothelial cells ( CVECs ) . Positive_regulation PLAU FGF2 9314544 455530 Stimulation of EC with *resulted* in increased expression of Hox D3 , integrin alphavbeta3 , and the [urokinase plasminogen activator (uPA)] . Positive_regulation PLAU FGF2 9314544 455536 Hox D3 antisense blocked the ability of to *induce* [uPA] and integrin alphavbeta3 expression , yet had no effect on EC cell proliferation or bFGF mediated cyclin D1 expression . Positive_regulation PLAU FGF2 9398667 469056 Finally , anti-alphavbeta3 monoclonal and polyclonal antibodies specifically inhibit mitogenesis and [urokinase-type plasminogen activator] ( uPA ) up-regulation *induced* by free in endothelial cells adherent to tissue culture plastic . Positive_regulation PLAU FGF2 9409785 471521 Cooperation of two PEA3/AP1 sites in [uPA] gene *induction* by TPA and . Positive_regulation PLAU FGF2 9442043 483066 Using L6E9 skeletal myoblasts , devoid of endogenous FGF receptors , which have been engineered to express either FGF receptor-1 (FGFR1) or FGF receptor-4 (FGFR4) , we have demonstrated that both receptors , known to be expressed in skeletal muscle cell precursors , were able to mediate [uPA] *induction* by , whereas serum stimulation was FGF receptor independent . Positive_regulation PLAU FGF2 9442043 483067 The *induction* of [uPA] by and serum in FGFR1- and in FGFR4 expressing myoblasts required the mitogen activated protein kinase pathway , since treatment of cells with a specific inhibitor of the mitogen activated protein kinase/extracellular signal regulated kinase-2 kinase , PD98059 , blocked uPA promoter induction . Positive_regulation PLAU FGF2 9442043 483069 Although and serum *induced* [uPA] in proliferating myoblasts , their actions on cell-cell contact induced differentiating myoblasts differed dramatically . Positive_regulation PLAU FGF2 9880324 583823 In particular , phosphorylation of either Y463 or Y730 , dispensable for mitogenic signaling , represents an absolute requirement for mediated [uPA] *induction* . Positive_regulation PLAU FGF20 1905574 161595 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Positive_regulation PLAU FGF20 8868466 389237 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Positive_regulation PLAU FGF21 1905574 161596 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Positive_regulation PLAU FGF21 8868466 389238 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Positive_regulation PLAU FGF22 1905574 161597 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Positive_regulation PLAU FGF22 8868466 389239 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Positive_regulation PLAU FGF23 1905574 161598 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Positive_regulation PLAU FGF23 8868466 389240 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Positive_regulation PLAU FGF3 1905574 161599 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Positive_regulation PLAU FGF3 8868466 389241 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Positive_regulation PLAU FGF4 14996996 1220490 VEGF , EGF , and FGF-10 , but not FGF-2 , *stimulate* the activity of trophoblast [uPA] , PAI-1 and MMP-9 . Positive_regulation PLAU FGF4 1905574 161600 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Positive_regulation PLAU FGF4 8868466 389242 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Positive_regulation PLAU FGF5 1905574 161601 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Positive_regulation PLAU FGF5 8868466 389243 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Positive_regulation PLAU FGF6 1905574 161602 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Positive_regulation PLAU FGF6 8868466 389244 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Positive_regulation PLAU FGF7 12458339 1021596 Src/ERK but not phospholipase D is involved in *stimulated* secretion of matrix metalloprotease-9 and [urokinase-type plasminogen activator] in SNU-16 human stomach cancer cell . Positive_regulation PLAU FGF7 1905574 161603 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Positive_regulation PLAU FGF7 8868466 389245 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Positive_regulation PLAU FGF7 8907612 394494 *enhances* [urokinase-type plasminogen activator] activity in HPV16 DNA immortalized human uterine exocervical epithelial cells . Positive_regulation PLAU FGF8 1905574 161604 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Positive_regulation PLAU FGF8 8868466 389246 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Positive_regulation PLAU FGF9 1905574 161605 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Positive_regulation PLAU FGF9 8868466 389247 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Positive_regulation PLAU FGFR1 9880324 583820 Different tyrosine autophosphorylation requirements in *mediate* [urokinase-type plasminogen activator] induction and mitogenesis . Positive_regulation PLAU FN1 11495705 846374 Free and immobilized vitronectin and *stimulated* the proliferation of cells under serum-free conditions and the production and release of [urokinase-type plasminogen activator] , and increased the release of the activated forms of matrix metalloproteinase-2 and matrix metalloproteinase-9 in an alpha(v)beta(3) integrin dependent manner . Positive_regulation PLAU FN1 12413883 1010990 The positive effect of basic fibroblast growth factor (bFGF) on [uPA] enzymatic activity was slightly potentiated in the *presence* of . Positive_regulation PLAU FOS 8300623 248673 DNA-protein interaction studies , together with mRNA and protein analyses , indicate that c-Jun , but not , is *involved* in OA-dependent [uPA] gene induction . Positive_regulation PLAU FOXO3 18239069 1895715 ChIP and luciferase assays confirm that can both occupy and *transactivate* the [uPA] promoter . Positive_regulation PLAU FPR2 11818541 908611 In this article we show that ( i ) both uPAR and are *necessary* for the chemotactic activity of [uPA] whereas FPRL1/LXA4R is sufficient to mediate D2D3 ( 88-274 ) -induced cell migration . Positive_regulation PLAU GATA6 21076612 2345137 Accordingly , GATA6 physically associated with Sp1 and siRNA knockdown of Sp1 decreased GATA6 activation of the uPA promoter activity suggesting that Sp1 recruits GATA6 to the uPA promoter and mediates *induced* activation of the [uPA] promoter activity . Positive_regulation PLAU GDF15 12907645 1119269 Similarly , the stimulation of gastric cancer cell lines with purified recombinant dose-dependently *increased* cell invasiveness , [uPA] activity , and uPA and uPAR expression . Positive_regulation PLAU GEMIN4 12750156 1119613 Moreover , the activation of plasminogen by [pro-uPA] is *increased* by soluble . Positive_regulation PLAU GEMIN4 12750156 1119619 These results indicate that membrane bound and soluble p97 affect the migration capacity of endothelial and melanoma cells and suggest that could be *involved* in the regulation of plasminogen activation by interacting with [pro-uPA] and plasminogen . Positive_regulation PLAU GIF 11814314 892827 We have examined expression of the components of the plasminogen activation system in human astrocytoma U373-MG cells and found that interleukin 1beta (IL-1beta) , tumour necrosis factor alpha TNF-alpha ) , and epidermal growth factor (EGF) specifically *regulate* the expression of tissue-type plasminogen activator (t-PA) , [urokinase-type plasminogen activator] ( u-PA ) , plasminogen activator inhibitor type 1 ( PAI-1 ) and protease nexin-1 (PN-1) . Positive_regulation PLAU GNRH1 12466358 1022350 Both and II *increased* [uPA] and concomitantly decreased PAI-1 mRNA and protein expression levels in our extravillous cytotrophoblast cultures in a dose- and time dependent manner . Positive_regulation PLAU GRAP2 10766865 684614 [Urokinase plasminogen activator/urokinase-specific] surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive mitogen activated protein kinase activity . Positive_regulation PLAU GRAP2 17611702 1768677 Specific inhibitors were utilized to determine if interference with the ( MAPK ) , p42/44 ( MAPK ) , and PI3K pathways functionally *blocked* LPA mediated [uPA] secretion . Positive_regulation PLAU GRAP2 17611702 1768691 Inhibition of ( MAPK ) signaling by SB202190 completely abrogated LPA induced uPA secretion , while inhibition of the p42/44 ( MAPK ) or PI3K pathways with PD98059 or wortmannin and LY294002 , respectively , decreased but did not completely *block* [uPA] secretion . Positive_regulation PLAU GRAP2 9515796 492233 We found that inhibition of by SB 203580 *resulted* in the almost complete reduction of phorbol myristate acetate induced MMP-9 secretion but not of [urokinase-type plasminogen activator] secretion . Positive_regulation PLAU GRB2 9038378 415567 Regulation of the [urokinase-type plasminogen activator] gene by the oncogene Tpr-Met *involves* . Positive_regulation PLAU HCG11 9433919 474535 In-vitro experiments showed that both tPA and [uPA] activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAU HCG14 9433919 474536 In-vitro experiments showed that both tPA and [uPA] activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAU HCG15 9433919 474537 In-vitro experiments showed that both tPA and [uPA] activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAU HCG16 9433919 474540 In-vitro experiments showed that both tPA and [uPA] activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAU HCG17 9433919 474551 In-vitro experiments showed that both tPA and [uPA] activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAU HCG18 9433919 474550 In-vitro experiments showed that both tPA and [uPA] activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAU HCG20 9433919 474548 In-vitro experiments showed that both tPA and [uPA] activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAU HCG21 9433919 474549 In-vitro experiments showed that both tPA and [uPA] activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAU HCG22 9433919 474546 In-vitro experiments showed that both tPA and [uPA] activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAU HCG23 9433919 474538 In-vitro experiments showed that both tPA and [uPA] activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAU HCG24 9433919 474544 In-vitro experiments showed that both tPA and [uPA] activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAU HCG25 9433919 474539 In-vitro experiments showed that both tPA and [uPA] activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAU HCG26 9433919 474547 In-vitro experiments showed that both tPA and [uPA] activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAU HCG27 9433919 474545 In-vitro experiments showed that both tPA and [uPA] activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAU HCG4 9433919 474541 In-vitro experiments showed that both tPA and [uPA] activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAU HCG8 9433919 474542 In-vitro experiments showed that both tPA and [uPA] activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAU HCG9 9433919 474543 In-vitro experiments showed that both tPA and [uPA] activities in epididymal cells were dramatically *stimulated* by , but not by follicle stimulating hormone ( FSH ) . Positive_regulation PLAU HDAC1 22797919 2706076 PKD2 and PKD3 promote prostate cancer cell invasion by modulating NF-?B- and mediated expression and *activation* of [uPA] . Positive_regulation PLAU HDAC1 22797919 2706089 Taken together , these data suggest that PKD2 and PKD3 coordinate to promote prostate cancer cell invasion through p65 NF-?B- and mediated expression and *activation* of [uPA] . Positive_regulation PLAU HGF 10496342 647203 Likewise , strongly *enhanced* [urokinase-type plasminogen activator] activity and invasion of MMT cells through Matrigel : a 15-fold stimulation in the invasion of MMT cells was seen by HGF . Positive_regulation PLAU HGF 10889138 710401 In human fibroblasts , significantly *increased* the production of matrix metalloprotease-1 (MMP-1) and [urokinase plasminogen activator] , whereas HGF also significantly attenuated the reduction of MMP-1 activity induced by Ang II . Positive_regulation PLAU HGF 11089886 580922 Simultaneous *up-regulation* of [urokinase-type plasminogen activator] ( uPA ) and uPA receptor by factor in human glioma cells . Positive_regulation PLAU HGF 12755996 1090567 *increased* [uPA] and uPAR production in a dose dependent manner up to 10 ng/mL , while effects of 20 ng/mL were approximately equal to those of 10 ng/mL . Positive_regulation PLAU HGF 12755996 1090569 *stimulated* [uPA] production beyond that in control cultures from 8 h until 48 h after HGF addition . Positive_regulation PLAU HGF 14598883 1161240 To investigate the role of HGF/c-met signaling on metastasis in cancer cells stimulated with HGF , we examined the effects of a specific MEK1 inhibitor ( PD98059 ) and a p38 MAP kinase inhibitor ( SB203580 ) on *induced* [uPA] expression in pancreatic cancer cell lines , L3.6PL and IMIM-PC2 . Positive_regulation PLAU HGF 14598883 1161246 Pretreatment of PD98059 decreased *mediated* phosphorylation of extracellular receptor kinase (ERK) , [uPA] secretion and expression of matrix metalloproteinases ( MMP-2 and MMP-9 ) in a dose dependent manner . Positive_regulation PLAU HGF 14598883 1161248 In contrast , SB203580 pretreatment increased *stimulated* ERK phosphorylation , [uPA] secretion and expression of MMPs . Positive_regulation PLAU HGF 15042617 1224569 Enhanced invasion of hormone refractory prostate cancer cells through *induction* of [urokinase-type plasminogen activator] ( u-PA ) . Positive_regulation PLAU HGF 15782129 1410033 *Induction* of the [urokinase-type plasminogen activator] ( uPA ) by factor ( HGF/SF ) plays an important role in tumor cell invasion and metastasis that is mediated through the Met receptor tyrosine kinase . Positive_regulation PLAU HGF 15782129 1410034 Previously , we have shown that a subset of GA derivatives exhibit exquisite potency , inhibiting *induced* [uPA-plasmin] activation at femtomolar concentrations ( fM-GAi ) in canine MDCK cells . Positive_regulation PLAU HGF 15782129 1410036 Here , we report that ( 1 ) inhibition of *induced* [uPA] activity by fM-GAi is not uncommon , in that several human tumor glioblastoma cell lines ( DBTRG , U373 and SNB19 ) , as well as SK-LMS-1 human leiomyosarcoma cells are also sensitive to fM-GAi ; Positive_regulation PLAU HGF 15782129 1410037 ( 2 ) fM-GAi drugs only display inhibitory activity against *induced* [uPA] activity ( rather than basal activity ) , and only when the observed magnitude of uPA activity induction by HGF/SF is at least 1.5 times basal uPA activity ; Positive_regulation PLAU HGF 15849510 1399158 IGF-I and cooperate to induce migration and invasion of CRC cells , and c-Met and [uPA/uPAR] are *required* for IGF-I mediated migration and invasion . Positive_regulation PLAU HGF 15869463 1439689 *Activation* of by [urokinase-type plasminogen activator] is ionic strength dependent . Positive_regulation PLAU HGF 16140945 1450938 In addition , IGF-I and *induced* [uPA] and uPAR expression in L3.6pl cells . Positive_regulation PLAU HGF 17992475 1860059 *Role* of signaling in regulating [urokinase plasminogen activator] on invasiveness in human hepatocellular carcinoma : a potential therapeutic target . Positive_regulation PLAU HGF 17992475 1860064 *enhanced* the protein level and the activity of [uPA] in HepG2 and Hep3B cells , and the uPAR protein level also increased in a HGF dose dependent manner . Positive_regulation PLAU HGF 18632202 1972524 We also observed that *enhanced* the activity of matrix metalloproteinase (MMP)-9 and [urokinase-type plasminogen activator] ( uPA ) in hypopharyngeal carcinoma cells . Positive_regulation PLAU HGF 18632202 1972527 On the other hand , EGCG at physiologically relevant concentration ( 1 microM ) suppressed *induced* tumor motility and MMP-9 and [uPA] activities , and the suppression of Akt and Erk pathway by EGCG was one of the downstream mechanisms to facilitate EGCG induced anti-invasion effects . Positive_regulation PLAU HGF 19497102 2098076 regulates Rac-1 induced ROS production through the Akt pathway and ROS *regulates* [uPA] production and invasion via MAP kinase , which provides novel insight into the mechanisms underlying the progression of gastric cancer . Positive_regulation PLAU HGF 20559690 2315801 These results demonstrated that HDACs regulate *induced* [uPA] and MMP-9 expression through a PKC dependent signal pathway in gastric cancer cells . Positive_regulation PLAU HGF 21209554 2391896 In the cell based screening assay , ( - ) epigallocatechin-3-gallate ( EGCG ) inhibited HGF/SF-Met signaling as indicated by its inhibitory activity on *induced* cell scattering and [uPA] activation ( IC50=15.8 microgram/ml ) . Positive_regulation PLAU HGF 21734448 2484022 *induced* up-regulation of [uPA] was repressed by survivin knockdown . Positive_regulation PLAU HGF 21734448 2484024 In conclusion , survivin appeared to play an important role in the up-regulation of [uPA] *induced* by via JunB and might contribute to HGF mediated tumor invasion and metastasis , which may serve as a promising target for gastric cancer therapy . Positive_regulation PLAU HGF 21892609 2521920 In MDA-MB-231 cells , BITC reduced both basal and *induced* secretion and activity of [urokinase-type plasminogen activator] ( uPA ) . Positive_regulation PLAU HGF 21892609 2521930 LY294002 , a specific Akt inhibitor , reduced both basal and *induced* [uPA] secretion and migration of MDA-MB-231 cells . Positive_regulation PLAU HGF 8622656 354390 A strong correlation has previously been demonstrated between the activation of the urokinase plasminogen activator (uPA) proteolysis network and the acquisition of the invasive-metastatic phenotype , and we show here that signalling significantly *increases* the protein levels of both [uPA] and its cellular receptor in SK-LMS-1 cells . Positive_regulation PLAU HNF1B 7665606 322018 *Role* of in cell-specific cAMP induction of the [urokinase-type plasminogen activator] gene . Positive_regulation PLAU HOXD3 10648567 662091 We have previously established that is *required* for expression of integrin alphavbeta3 and [urokinase plasminogen activator (uPA)] , which contribute to EC adhesion , invasion , and migration during angiogenesis . Positive_regulation PLAU HOXD3 9314544 455544 Expression of , in the absence of bFGF , *resulted* in enhanced expression of integrin alphavbeta3 and [uPA] . Positive_regulation PLAU HRAS 18383343 1899167 Inhibitors of ( FTA ) , Raf ( Bay 54-9085 ) and MEK ( UO126 ) , but not of phosphatidylinositol 3-kinase (PI3K) ( LY294002 ) and of protein kinase C ( BIM ) pathways , *inhibited* [uPA] activity and cell invasion . Positive_regulation PLAU HRAS 18383343 1899177 Our results suggest that *increased* [uPA] expression and activity via the Ras/Raf/MEK signaling pathway leading to enhanced cell invasion and this may contribute to increased invasive growth properties of astrocytomas . Positive_regulation PLAU HRG 11196203 779634 and PGE2 each induced the formation of well organized , three-dimensional structures with empty spaces in the center and *stimulated* the expression of [urokinase plasminogen activator (uPA)] with differential localization of membrane bound uPA at the focal adhesion points and leading edges of the motile cells . Positive_regulation PLAU IFI44 17611702 1768675 Specific inhibitors were utilized to determine if interference with the p38 ( MAPK ) , ( MAPK ) , and PI3K pathways functionally *blocked* LPA mediated [uPA] secretion . Positive_regulation PLAU IFIT1 14699120 1211601 To our knowledge , this is the first report that ( lck ) in presence of H/R *regulates* MEK-1 dependent ERK1/2 phosphorylation and [uPA] secretion through tyrosine phosphorylation of EGF receptor , and it further demonstrates that all of these signaling molecules ultimately control the motility of breast cancer cells . Positive_regulation PLAU IFNA1 12070711 955881 *upregulates* [urokinase-type plasminogen activator] receptor gene expression . Positive_regulation PLAU IFNA10 12070711 955882 *upregulates* [urokinase-type plasminogen activator] receptor gene expression . Positive_regulation PLAU IFNA13 12070711 955883 *upregulates* [urokinase-type plasminogen activator] receptor gene expression . Positive_regulation PLAU IFNA14 12070711 955884 *upregulates* [urokinase-type plasminogen activator] receptor gene expression . Positive_regulation PLAU IFNA16 12070711 955885 *upregulates* [urokinase-type plasminogen activator] receptor gene expression . Positive_regulation PLAU IFNA17 12070711 955886 *upregulates* [urokinase-type plasminogen activator] receptor gene expression . Positive_regulation PLAU IFNA2 12070711 955887 *upregulates* [urokinase-type plasminogen activator] receptor gene expression . Positive_regulation PLAU IFNA21 12070711 955888 *upregulates* [urokinase-type plasminogen activator] receptor gene expression . Positive_regulation PLAU IFNA4 12070711 955889 *upregulates* [urokinase-type plasminogen activator] receptor gene expression . Positive_regulation PLAU IFNA5 12070711 955890 *upregulates* [urokinase-type plasminogen activator] receptor gene expression . Positive_regulation PLAU IFNA6 12070711 955891 *upregulates* [urokinase-type plasminogen activator] receptor gene expression . Positive_regulation PLAU IFNA7 12070711 955892 *upregulates* [urokinase-type plasminogen activator] receptor gene expression . Positive_regulation PLAU IFNA8 12070711 955893 *upregulates* [urokinase-type plasminogen activator] receptor gene expression . Positive_regulation PLAU IGF1 11245436 793088 *Up-regulation* of [urokinase-type plasminogen activator] by depends upon phosphatidylinositol-3 kinase and mitogen activated protein kinase kinase . Positive_regulation PLAU IGF1 11245436 793090 *Induction* of [uPA] protein by was partially inhibited by LY294002 ( 60 % inhibition ) or PD98059 ( 30 % inhibition ) but not by rapamycin . Positive_regulation PLAU IGF1 11245436 793093 Next , using a minimal uPA-luciferase promoter construct containing the binding sites for the AP-1 and Ets transcription factors , we observed that *stimulated* the [uPA] promoter via these sites . Positive_regulation PLAU IGF1 11245436 793094 Furthermore , both Ly294002 and PD98059 were necessary to block *stimulated* [uPA-Luc] activity . Positive_regulation PLAU IGF1 11245436 793095 In summary , we conclude that *requires* both phosphatidylinositol 3-kinase and mitogen activated protein kinase kinase dependent pathways to optimally induce [uPA] expression . Positive_regulation PLAU IGF1 15694866 1371725 Moreover , it has been suggested that induces ligand independent activation of the androgen receptor and *enhances* the expression of matrix metalloproteinase-2 and [urokinase plasminogen activator] . Positive_regulation PLAU IGF1 15849510 1399159 and HGF cooperate to induce migration and invasion of CRC cells , and c-Met and [uPA/uPAR] are *required* for IGF-I mediated migration and invasion . Positive_regulation PLAU IGF1 16140945 1450932 We investigated the hypotheses that ( a ) and hepatocyte growth factor (HGF) mediated migration and invasion of human pancreatic carcinoma cells *require* [uPA] and uPAR function and ( b ) inhibition of uPAR inhibits tumor growth , retroperitoneal invasion , and hepatic metastasis of human pancreatic carcinomas in mice . Positive_regulation PLAU IGF1 16140945 1450939 In addition , and HGF *induced* [uPA] and uPAR expression in L3.6pl cells . Positive_regulation PLAU IGF1 16806868 1599831 *stimulated* SERPINE2 secretion and [uPA] activity , and decreased secreted tPA activity and gene expression . Positive_regulation PLAU IGF1 8631597 356541 In addition , we found that *enhanced* secreted [uPA] activity in both M3 and MM3 cells while IGF-II only stimulated uPA secretion in MM3 cells . Positive_regulation PLAU IGF1 8827475 385369 Insulin and *increased* synthesis of [urokinase plasminogen activator] and enhanced proliferation of cultured bovine mammary epithelial cells . Positive_regulation PLAU IGF1R 10642432 660818 Taken together , these data illustrate that *stimulates* [uPA] production . Positive_regulation PLAU IGF2 8631597 356542 In addition , we found that IGF-I *enhanced* secreted [uPA] activity in both M3 and MM3 cells while only stimulated uPA secretion in MM3 cells . Positive_regulation PLAU IL10 10454570 638008 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL10 18819934 1970356 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL11 10454570 638009 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL11 18819934 1970357 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL13 10454570 638010 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL13 18819934 1970358 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL13 9450789 483995 In contrast , IL-4 and *induced* a decrease in uPAR after 18 h and a significant increase in [uPA] both in the cell lysates and at the cell surface , as well as an increase in cell surface associated CD11b . Positive_regulation PLAU IL15 10454570 638011 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL15 18819934 1970359 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL16 10454570 638012 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL16 18819934 1970360 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL18 10454570 638013 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL18 18819934 1970361 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL19 10454570 638014 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL19 18819934 1970362 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL1A 12390531 1000535 Here , we show that oncostatin M (OSM) and *regulate* the expression of plasminogen activator inhibitor-1 ( PAI-1 ) and [urokinase-type plasminogen activator] ( uPA ) in human astrocytes . Positive_regulation PLAU IL1A 16504015 1529139 In this study , we investigated whether *induces* the alterations of integrin subunits and [urokinase plasminogen activator/urokinase] plasminogen activator receptor ( uPA/uPAR ) expression in pancreatic cancer cells . Positive_regulation PLAU IL1A 16504015 1529146 Based on these findings , we conclude that can *induce* selective upregulation of alpha6beta1-integrin and [uPA/uPAR] in pancreatic cancer cells and these changes may modulate the aggressive functions of pancreatic cancer . Positive_regulation PLAU IL1A 1905804 161649 Transcription of the human urokinase type plasminogen activator ( [uPA] ) gene in HeLa cells is *induced* by phorbol myristate acetate ( PMA ) , and tumor necrosis factor alpha (TNF alpha) . Positive_regulation PLAU IL1A 1905804 161658 Our results suggest that maximal transcriptional *activation* of the [uPA] gene by PMA , and TNF alpha requires the induction of NFkB activity and the decay of a short lived repressor protein , possibly IkB . Positive_regulation PLAU IL1A 8061114 268529 Interferon-alpha 2 counteracts *stimulated* expression of [urokinase-type plasminogen activator] in human foreskin microvascular endothelial cells in vitro . Positive_regulation PLAU IL1A 8061114 268530 We investigated the effect of interferon-alpha 2 ( IFN-alpha 2 ) on *induced* up-regulation of [urokinase type plasminogen activator] ( u-PA ) expression in human foreskin microvascular endothelial cells ( HFMEC ) and human umbilical vein endothelial cells ( HUVEC ) in vitro . Positive_regulation PLAU IL1A 8772229 344228 Recombinant , recombinant IL-1 beta and LPS but not recombinant IL-6 , recombinant TNF alpha and TGF beta dose-dependently *increased* [uPA] accumulation in the conditioned medium . Positive_regulation PLAU IL1A 8772229 344230 Both and IL- 1 beta rapidly *activated* [uPA] gene transcription , but not increased stability of uPA mRNA . Positive_regulation PLAU IL1A 8772229 344234 These results suggest that both and IL-1 beta *cause* a rapid activation of [uPA] gene transcription in which de novo protein synthesis is not required and that LPS induces uPA gene expression independently of the IL-1 pathway . Positive_regulation PLAU IL1B 11238529 790735 *regulates* [urokinase plasminogen activator (u-PA)] , u-PA receptor , soluble u-PA receptor , and plasminogen activator inhibitor-1 messenger ribonucleic acid expression in cultured human endometrial stromal cells . Positive_regulation PLAU IL1B 11519039 851879 We previously reported that both and LPS *induce* [uPA] in RC-K8 human lymphoma cells . Positive_regulation PLAU IL1B 11758807 887685 In addition , *increased* the protein and mRNA levels of both [uPA] and uPAR in gingival fibroblasts . Positive_regulation PLAU IL1B 11758807 887687 These findings suggest that the *enhancement* of [uPA] and uPAR levels by may play an important role in the progression of periodontal diseases through pericellular proteolysis , and subsequent cellular behavior . Positive_regulation PLAU IL1B 11814314 892828 We have examined expression of the components of the plasminogen activation system in human astrocytoma U373-MG cells and found that , tumour necrosis factor alpha TNF-alpha ) , interferon gamma (INF-gamma) and epidermal growth factor (EGF) specifically *regulate* the expression of tissue-type plasminogen activator (t-PA) , [urokinase-type plasminogen activator] ( u-PA ) , plasminogen activator inhibitor type 1 ( PAI-1 ) and protease nexin-1 (PN-1) . Positive_regulation PLAU IL1B 1481722 208212 *stimulated* [uPA] and tPA activity . Positive_regulation PLAU IL1B 1481722 208214 TGF-beta 1 inhibited *stimulated* [uPA] activity , but the effect on tPA was more variable . Positive_regulation PLAU IL1B 18202522 1839017 *stimulates* [urokinase-type plasminogen activator] expression and secretion in human dental pulp cells . Positive_regulation PLAU IL1B 18202522 1839018 The *stimulated* [uPA] mRNA expression and PA activities in the cell lysate and medium were reduced by the tyrosine kinase inhibitors herbimycin A and genistein , and by the NFkappaB inhibitor pyrolidinedithiocarbamate , and were augmented by the tyrosine phosphatase inhibitor sodium orthovanadate . Positive_regulation PLAU IL1B 8772229 344231 Both IL-1 alpha and rapidly *activated* [uPA] gene transcription , but not increased stability of uPA mRNA . Positive_regulation PLAU IL1B 8772229 344235 These results suggest that both IL-1 alpha and *cause* a rapid activation of [uPA] gene transcription in which de novo protein synthesis is not required and that LPS induces uPA gene expression independently of the IL-1 pathway . Positive_regulation PLAU IL1B 8826848 385274 Tumour necrosis factor alpha (TNF-alpha) and *increased* in several , but not all , cell lines the production of [urokinase-type plasminogen activator] ( uPA ) , tissue-type PA (tPA) and plasminogen activator inhibitor type 1 ( PAI-1 ) as analysed by zymography , enzyme immunoassays and Northern analysis . Positive_regulation PLAU IL2 10454570 638015 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL2 11890690 920420 *mediated* upregulation of [uPA] and uPAR in natural killer cells . Positive_regulation PLAU IL2 11890690 920423 These data suggest that *upregulates* both [uPA] and uPAR in NK cells through posttranscriptional as well as transcriptional mechanisms , partially explaining increases in NK cell invasiveness following IL-2 stimulation . Positive_regulation PLAU IL2 18819934 1970363 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL2 9688934 522682 The secretion of [uPA] and plasminogen activator inhibitor-1 from HLMECs was also *enhanced* by tumor necrosis factor-alpha and . Positive_regulation PLAU IL20 10454570 638016 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL20 18819934 1970364 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL21 10454570 638017 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL21 18819934 1970365 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL22 10454570 638000 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL22 18819934 1970348 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL24 10454570 637998 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL24 18819934 1970346 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL25 10454570 637999 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL25 18819934 1970347 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL26 10454570 638004 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL26 18819934 1970352 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL27 10454570 638005 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL27 18819934 1970353 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL3 10454570 638018 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL3 1846764 153351 Purified hematopoietic growth factors such as colony stimulating factor-1 (CSF-1) or macrophage CSF , granulocyte-macrophage CSF , and or multi-CSF , *stimulate* the [urokinase-type plasminogen activator] ( u-PA ) activity of murine bone marrow derived macrophages ( BMM ) and resident peritoneal macrophages . Positive_regulation PLAU IL3 18819934 1970366 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL31 10454570 638006 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL31 18819934 1970354 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL32 10454570 638003 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL32 18819934 1970351 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL33 10454570 638002 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL33 18819934 1970350 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL34 10454570 638007 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL34 18819934 1970355 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL37 10454570 638001 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL37 18819934 1970349 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL4 10454570 638019 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL4 18819934 1970367 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL4 8507866 221528 *stimulates* expression of [urokinase-type-plasminogen activator] in cultured human foreskin microvascular endothelial cells . Positive_regulation PLAU IL4 9450789 483996 In contrast , and IL-13 *induced* a decrease in uPAR after 18 h and a significant increase in [uPA] both in the cell lysates and at the cell surface , as well as an increase in cell surface associated CD11b . Positive_regulation PLAU IL4 9450789 483998 In addition , the increase in [uPA] *induced* by could counterbalance the direct interaction of uPAR with vitronectin . Positive_regulation PLAU IL5 10454570 638020 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL5 18819934 1970368 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL6 10454570 638021 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL6 17849265 1795822 Moreover , *increased* the activity of [urokinase type plasminogen activator] ( uPA ) in MG-63 cells , which was inhibited by SB203580 , PDTC and NF-kappaB SN50 . Positive_regulation PLAU IL6 17849265 1795824 This strongly suggests that p38 MAPK and NF-kappaB are essential to the induced *activation* of cathepsin B or [uPA] and that these two IL-6 activated pathways can act independently . Positive_regulation PLAU IL6 18819934 1970369 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL6 8772229 344229 Recombinant IL-1 alpha , recombinant IL-1 beta and LPS but not recombinant , recombinant TNF alpha and TGF beta dose-dependently *increased* [uPA] accumulation in the conditioned medium . Positive_regulation PLAU IL7 10454570 638022 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL7 18819934 1970370 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL8 10454570 638023 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL8 12175988 976886 In this report , we show that , but not other cytokines tested , is a potent *inducer* of the 38-kDa [uPA] in organ cultured human skin . Positive_regulation PLAU IL8 18819934 1970371 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU IL9 10454570 638024 Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2 , ATF-2 , and Jun family members in human [urokinase-type plasminogen activator] gene *induction* by and tetradecanoyl phorbol acetate . Positive_regulation PLAU IL9 18819934 1970372 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Positive_regulation PLAU ILF3 22986534 2833259 Using a collection of transcription factor targeted small interfering RNAs , we discovered that ( ILF3 ) is *required* for sustained [uPA] expression . Positive_regulation PLAU ILF3 22986534 2833260 The first is that *activates* [uPA] transcription by binding to the CTGTT sequence in the nucleotides -1004~-1000 of the uPA promoter ; Positive_regulation PLAU ILF3 22986534 2833262 Nuclear localization of ILF3 highlights the *role* of in sustained [uPA] expression as a transcription activator and pri-miRNA processing blocker . Positive_regulation PLAU INS 1576255 187322 also *stimulated* [uPa] and tPa production by prepubertal Sertoli cells , and retinol significantly suppressed uPa production and the ability of FSH to stimulate tPa production by midpubertal Sertoli cells . Positive_regulation PLAU INS 8827475 385370 and IGF-I *increased* synthesis of [urokinase plasminogen activator] and enhanced proliferation of cultured bovine mammary epithelial cells . Positive_regulation PLAU ITGA3 10791952 714400 [Urinary-type plasminogen activator (uPA)] expression and uPA receptor localization are *regulated* by in oral keratinocytes . Positive_regulation PLAU ITGAM 23060546 2685564 MDSC can be recruited by [uPA] , and uPAR but not are *required* for such recruitment . Positive_regulation PLAU ITGAV 11051458 743422 In the present study , HT-1080 cell lines expressing either wild-type vitronectin or vitronectin containing a single amino-acid substitution in the integrin binding domain were used to assess whether ligation of the was *required* for [uPA] localization to focal adhesions . Positive_regulation PLAU ITGB1 10791952 714401 [Urinary-type plasminogen activator (uPA)] expression and uPA receptor localization are *regulated* by in oral keratinocytes . Positive_regulation PLAU ITGB5 11051458 743423 In the present study , HT-1080 cell lines expressing either wild-type vitronectin or vitronectin containing a single amino-acid substitution in the integrin binding domain were used to assess whether ligation of the was *required* for [uPA] localization to focal adhesions . Positive_regulation PLAU JUN 10942386 721318 Taken together , our results show that the JNK signaling pathway links external MNNG stimulation and *dependent* [uPA] gene expression , providing the first functional dissection of a transcription coupled signal transduction pathway for MNNG . Positive_regulation PLAU JUN 11050091 786171 PMA could also activate a signaling pathway involving *dependent* [uPA] expression . Positive_regulation PLAU JUN 11774742 890608 We next asked whether the mechanism of inhibition of uPA expression by bik is due to interference with MAP kinase , since PMA could also activate a signaling pathway involving *dependent* [uPA] expression . Positive_regulation PLAU JUN 14704150 1219036 Osteopontin induces *mediated* secretion of [urokinase-type plasminogen activator] through c-Src dependent epidermal growth factor receptor transactivation in breast cancer cells . Positive_regulation PLAU JUN 14704150 1219070 To our knowledge , this is the first report that OPN induces alpha(v)beta(3) integrin mediated AP-1 activity and uPA secretion by activating c-Src/EGFR/ERK signaling pathways and further demonstrates a functional molecular link between OPN induced integrin/c-Src dependent EGFR phosphorylation and *mediated* [uPA] secretion , and all of these ultimately control the motility of breast cancer cells . Positive_regulation PLAU JUN 15558021 1361108 Both FGF-2 and phorbol ester-inducible [urokinase-type plasminogen activator] ( uPA ) expression *requires* binding to an enhancer element in the uPA promoter , and we have previously shown that FGF-2 or PMA induction of uPA expression is strongly dependent on MEKK1 . Positive_regulation PLAU JUN 21567400 2562275 Inhibition of Sp1 and activation *blocked* the SDF-1 induced expression and activity of the [uPA] promoter . Positive_regulation PLAU JUN 8300623 248674 DNA-protein interaction studies , together with mRNA and protein analyses , indicate that , but not c-Fos , is *involved* in OA-dependent [uPA] gene induction . Positive_regulation PLAU JUN 8346015 226929 Here we show that the induction of the [uPA] gene by CSR is *mediated* by the activation of which interacts with an AP-1-like site located 2 kb upstream of the uPA gene . Positive_regulation PLAU JUN 9671463 519906 This activation links external UV stimulation and *dependent* [uPA] transcription , providing a transcription coupled signal transduction pathway for the induction of the murine uPA gene by UV . Positive_regulation PLAU JUN 9990071 597249 three overexpressed genes code for two components of the AP-1 transcription complex , c-jun and fra-1 , and for the [urokinase-type plasminogen activator] receptor ( uPAR ) , whose transcription is *activated* by . Positive_regulation PLAU KHSRP 16912916 1614854 These results indicate that expression of [uPA] , MMP-2 , MMP-9 , and TIMP-1 are directly *regulated* by expression of ( NTR ) and its downstream signal transduction cascade . Positive_regulation PLAU KLF6 10666204 665397 transcriptionally *activates* [urokinase plasminogen activator (uPA)] . Positive_regulation PLAU KLF6 10666204 665399 Furthermore , concomitant expression of Zf9 and uPA proteins was observed in arterial endothelial cells after balloon injury in rats , suggesting a potential *role* of in [uPA] expression not only in vitro but also in vivo . Positive_regulation PLAU KLKB1 12719778 1084078 These findings suggest that spontaneous fibrinolysis might be mediated by tPA and *dependent* [uPA] . Positive_regulation PLAU KRAS 18383343 1899168 Inhibitors of ( FTA ) , Raf ( Bay 54-9085 ) and MEK ( UO126 ) , but not of phosphatidylinositol 3-kinase (PI3K) ( LY294002 ) and of protein kinase C ( BIM ) pathways , *inhibited* [uPA] activity and cell invasion . Positive_regulation PLAU LAMA5 10791952 714411 Bead immobilized and collagen I , two major alpha ( 3 ) beta ( 1 ) ligands , also *induced* [uPA] expression . Positive_regulation PLAU LAMB2 10791952 714412 Bead immobilized and collagen I , two major alpha ( 3 ) beta ( 1 ) ligands , also *induced* [uPA] expression . Positive_regulation PLAU LAMC3 10791952 714413 Bead immobilized and collagen I , two major alpha ( 3 ) beta ( 1 ) ligands , also *induced* [uPA] expression . Positive_regulation PLAU LCK 14534291 1174963 Tyrosine kinase *regulates* cell motility and nuclear factor kappaB mediated secretion of [urokinase type plasminogen activator] through tyrosine phosphorylation of IkappaBalpha following hypoxia/reoxygenation . Positive_regulation PLAU LCK 14534291 1174983 Luciferase reporter gene assay indicated that *induces* NFkappaB dependent [urokinase type plasminogen activator] ( uPA ) promoter activity in presence of H/R . Positive_regulation PLAU LCK 14534291 1174987 To our knowledge , this is the first report that in presence of H/R *regulates* NFkappaB activation , [uPA] secretion , and cell motility through tyrosine phosphorylation of IkappaBalpha and further demonstrates an important redox regulated pathway for NFkappaB activation following H/R injury that is independent of IkappaB kinase/IkappaBalpha mediated signaling pathways . Positive_regulation PLAU LCK 14699120 1211597 DN Lck and inhibitors of , EGF receptor , and MEK-1 *suppressed* H/R induced [uPA] secretion and cell motility . Positive_regulation PLAU LEO1 15149885 1248451 Activation of receptor by oxidised LDL in human monocytes *stimulates* chemokine releases but not [urokinase-type plasminogen activator] expression . Positive_regulation PLAU LEO1 15149885 1248470 Our results indicated that oxidation products are responsible for the monocyte chemokine releases , but did not *contribute* to the enhanced monocyte [uPA] expression by oxidised LDL . Positive_regulation PLAU LEO1 9185044 436697 We have found that in the cornea , a potent lipid inflammatory mediator *activates* the expression of two metalloproteinases ( MMP-1 and MMP-9 ) as well as [urokinase-plasminogen activator (uPA)] . Positive_regulation PLAU LIF 7782459 309679 Recent experiments show that both and EGF *stimulate* secretion of [urokinase-type plasminogen activator] ( uPA ) and gelatinase B/matrix metalloproteinase-9 (MMP-9) in day 7 mouse blastocyst outgrowths . Positive_regulation PLAU LIF 8922882 397192 *increased* the accumulation of [urokinase plasminogen activator (u-PA)] in the Hep G2 cell culture supernatants determined by enzyme linked immunosorbent assay ( ELISA ) ( 0.21 +/- 0.03 ( SE ) ng/ml at baseline ; 0.40 +/- 0.05 ng/ml at 100 U/ml , P < 0.05 ; 0.57 +/- 0.06 ng/ml at 500 U/ml , P < 0.01 ; n = 9 ) without altering total protein content . Positive_regulation PLAU LPA 10589790 572232 Because LPA stimulates the invasion of both hepatoma and lung cell lines , we investigated whether could *induce* [uPA] secretion by ovarian epithelial cells and whether this process was associated with malignant transformation of ovarian epithelial cells . Positive_regulation PLAU LPA 10589790 572234 In contrast , expression of the edg-4 LPA receptor was markedly increased in ovarian cancer cell lines as compared with NOE cell lines , raising the possibility that the edg-4 LPA receptor contributes to the ability of ovarian cancer cells but not NOE cells to produce [uPA] in *response* to . Positive_regulation PLAU LPA 10589790 572237 induced a consistent *increase* in [uPA] promoter activity and mRNA levels , suggesting that increased uPA production is , at least in part , transcriptional . Positive_regulation PLAU LPA 15653692 1381596 *enhances* [urokinase plasminogen activator (uPA)] expression in ovarian cancer cells ; Positive_regulation PLAU LPA 15653692 1381597 In this study , we used the invasive ovarian cancer SK-OV-3 cell line to explore the signaling molecules and pathways essential for *induced* [uPA] up-regulation . Positive_regulation PLAU LPA 15653692 1381599 Moreover , constitutively active H-Ras and Raf-1 activating H-Ras mutant enhance uPA expression , whereas dominant negative H-Ras and Raf-1 block *induced* [uPA] up-regulation , suggesting that the Ras-Raf pathway works downstream of G ( i ) to mediate this LPA induced process . Positive_regulation PLAU LPA 15653692 1381601 Surprisingly , dominant negative MEK1 or Erk2 displays only marginal inhibitory effect on *induced* [uPA] up-regulation , suggesting that a signaling pathway distinct from Raf-MEK1/2-Erk is the prominent pathway responsible for this process . Positive_regulation PLAU LPA 15653692 1381602 In this report , we demonstrate that LPA activates NF-kappaB in a Ras-Raf dependent manner and that blocking NF-kappaB activation with either non-phosphorylable IkappaB or dominant negative IkappaB kinase abolished *induced* [uPA] up-regulation and uPA promoter activation . Positive_regulation PLAU LPA 15653692 1381606 Furthermore , introducing mutations to knock out the NF-kappaB binding site of the uPA promoter results in over 80 % reduction in *induced* [uPA] promoter activation , whereas this activity is largely intact with the promoter containing mutations in the AP1 binding sites . Positive_regulation PLAU LPA 15653692 1381607 Thus these results suggest that the G ( i ) -Ras-Raf-NF-kappaB signaling cascade is responsible for *induced* [uPA] up-regulation in ovarian cancer cells . Positive_regulation PLAU LPA 15919106 1413335 SU1498 also decreases the *induced* increase of [uPA] activity in DOV13 cells . Positive_regulation PLAU LPA 17611702 1768674 In this study we sought to elucidate which signaling pathway ( s ) are involved in *mediated* secretion of [uPA] from ovarian cancer cells . Positive_regulation PLAU LPA 17611702 1768692 Inhibition of p38 ( MAPK ) signaling by SB202190 completely abrogated *induced* [uPA] secretion , while inhibition of the p42/44 ( MAPK ) or PI3K pathways with PD98059 or wortmannin and LY294002 , respectively , decreased but did not completely block uPA secretion . Positive_regulation PLAU LPA 17611702 1768693 In contrast , inhibitors of phospholipase D or the p70S6 kinase pathway did not alter *induced* [uPA] secretion . Positive_regulation PLAU LPA 17611702 1768698 Finally , *induces* [uPA] secretion from ovarian cancer cells predominantly through the LPA2 receptor , with LPA3 contributing to this process . Positive_regulation PLAU LPA 17611702 1768699 These results indicate that the p38 ( MAPK ) signaling pathway is required for optimal *dependent* [uPA] secretion from ovarian cancer cells . Positive_regulation PLAU LPA 18073130 1861919 Kinetics of *induced* [uPA] activity was followed with a colorimetric enzymatic assay . Positive_regulation PLAU LPA 18461672 1909844 To explore the role of lysophosphatidic acid receptor-2 (LPA2) in regulating *induced* [urokinase plasminogen activator (uPA)] activation , cell invasion , and migration in human ovarian cancer cell line SKOV-3 . Positive_regulation PLAU LPA 18461672 1909846 stimulation significantly *enhanced* in vitro [uPA] activity in time- and dose dependent manner . Positive_regulation PLAU LPA 18461672 1909847 LPA2 has an essential role in *induced* [uPA] activation and tumor cell invasion in ovarian cancer SKOV-3 cells . Positive_regulation PLAU LPA 20056268 2218419 In addition , significantly *enhanced* [uPA] activity in HEC-1A conditioned medium in a concentration dependent manner . Positive_regulation PLAU LPA 22249252 2674872 *induced* matrix metalloproteinase (MMP)-9 expression in CAOV-3 and PA-1 cells and [urokinase-type plasminogen activator] ( uPA ) expression in SKOV-3 cells . Positive_regulation PLAU LPA 22249252 2674875 In addition , transfection with dominant negative Ras ( Ras N17 ) significantly inhibited *induced* Rho activation as well as MMP-9 and [uPA] expression . Positive_regulation PLAU LPA 22906080 2678028 Aggregated low-density *induce* impairment of the cytoskeleton dynamics through urokinase-type plasminogen [activator/urokinase-type plasminogen activator] receptor in human vascular smooth muscle cell . Positive_regulation PLAU LRP1 11359936 816710 Here we investigated whether direct interaction between uPAR , a glycosyl-phosphatidylinositol anchored protein , and , a transmembrane receptor , is *required* for clearance of [uPA] : PAI-1 , regeneration of unoccupied uPAR , activation of plasminogen , and the ability of HT1080 cells to invade extracellular matrix . Positive_regulation PLAU LRP1 16807059 1580426 Overall our results identified the *mediated* clearance of [uPA] as one of the mechanisms involved during the control of human thyroid carcinoma cell invasion . Positive_regulation PLAU LRP1 9665342 518431 Degradation of [urokinase plasminogen activator (UPA)] in endometrial stromal cells *requires* both the UPA receptor and the low-density lipoprotein receptor related . Positive_regulation PLAU LRP10 11359936 816707 Here we investigated whether direct interaction between uPAR , a glycosyl-phosphatidylinositol anchored protein , and , a transmembrane receptor , is *required* for clearance of [uPA] : PAI-1 , regeneration of unoccupied uPAR , activation of plasminogen , and the ability of HT1080 cells to invade extracellular matrix . Positive_regulation PLAU LRP10 16807059 1580423 Overall our results identified the *mediated* clearance of [uPA] as one of the mechanisms involved during the control of human thyroid carcinoma cell invasion . Positive_regulation PLAU LRP11 11359936 816708 Here we investigated whether direct interaction between uPAR , a glycosyl-phosphatidylinositol anchored protein , and , a transmembrane receptor , is *required* for clearance of [uPA] : PAI-1 , regeneration of unoccupied uPAR , activation of plasminogen , and the ability of HT1080 cells to invade extracellular matrix . Positive_regulation PLAU LRP11 16807059 1580424 Overall our results identified the *mediated* clearance of [uPA] as one of the mechanisms involved during the control of human thyroid carcinoma cell invasion . Positive_regulation PLAU LRP12 11359936 816709 Here we investigated whether direct interaction between uPAR , a glycosyl-phosphatidylinositol anchored protein , and , a transmembrane receptor , is *required* for clearance of [uPA] : PAI-1 , regeneration of unoccupied uPAR , activation of plasminogen , and the ability of HT1080 cells to invade extracellular matrix . Positive_regulation PLAU LRP12 16807059 1580425 Overall our results identified the *mediated* clearance of [uPA] as one of the mechanisms involved during the control of human thyroid carcinoma cell invasion . Positive_regulation PLAU LRP2 11359936 816711 Here we investigated whether direct interaction between uPAR , a glycosyl-phosphatidylinositol anchored protein , and , a transmembrane receptor , is *required* for clearance of [uPA] : PAI-1 , regeneration of unoccupied uPAR , activation of plasminogen , and the ability of HT1080 cells to invade extracellular matrix . Positive_regulation PLAU LRP2 16807059 1580427 Overall our results identified the *mediated* clearance of [uPA] as one of the mechanisms involved during the control of human thyroid carcinoma cell invasion . Positive_regulation PLAU LRP3 11359936 816712 Here we investigated whether direct interaction between uPAR , a glycosyl-phosphatidylinositol anchored protein , and , a transmembrane receptor , is *required* for clearance of [uPA] : PAI-1 , regeneration of unoccupied uPAR , activation of plasminogen , and the ability of HT1080 cells to invade extracellular matrix . Positive_regulation PLAU LRP3 16807059 1580428 Overall our results identified the *mediated* clearance of [uPA] as one of the mechanisms involved during the control of human thyroid carcinoma cell invasion . Positive_regulation PLAU LRP4 11359936 816713 Here we investigated whether direct interaction between uPAR , a glycosyl-phosphatidylinositol anchored protein , and , a transmembrane receptor , is *required* for clearance of [uPA] : PAI-1 , regeneration of unoccupied uPAR , activation of plasminogen , and the ability of HT1080 cells to invade extracellular matrix . Positive_regulation PLAU LRP4 16807059 1580429 Overall our results identified the *mediated* clearance of [uPA] as one of the mechanisms involved during the control of human thyroid carcinoma cell invasion . Positive_regulation PLAU LRP5 11359936 816714 Here we investigated whether direct interaction between uPAR , a glycosyl-phosphatidylinositol anchored protein , and , a transmembrane receptor , is *required* for clearance of [uPA] : PAI-1 , regeneration of unoccupied uPAR , activation of plasminogen , and the ability of HT1080 cells to invade extracellular matrix . Positive_regulation PLAU LRP5 16807059 1580430 Overall our results identified the *mediated* clearance of [uPA] as one of the mechanisms involved during the control of human thyroid carcinoma cell invasion . Positive_regulation PLAU LRP6 11359936 816715 Here we investigated whether direct interaction between uPAR , a glycosyl-phosphatidylinositol anchored protein , and , a transmembrane receptor , is *required* for clearance of [uPA] : PAI-1 , regeneration of unoccupied uPAR , activation of plasminogen , and the ability of HT1080 cells to invade extracellular matrix . Positive_regulation PLAU LRP6 16807059 1580431 Overall our results identified the *mediated* clearance of [uPA] as one of the mechanisms involved during the control of human thyroid carcinoma cell invasion . Positive_regulation PLAU LRP8 11359936 816716 Here we investigated whether direct interaction between uPAR , a glycosyl-phosphatidylinositol anchored protein , and , a transmembrane receptor , is *required* for clearance of [uPA] : PAI-1 , regeneration of unoccupied uPAR , activation of plasminogen , and the ability of HT1080 cells to invade extracellular matrix . Positive_regulation PLAU LRP8 16807059 1580432 Overall our results identified the *mediated* clearance of [uPA] as one of the mechanisms involved during the control of human thyroid carcinoma cell invasion . Positive_regulation PLAU LRPAP1 22298529 2546360 [uPA] enzymatic activity was also increased in LRP-1-deficient and neutralized cells , and *potentiated* uPA dependent migration in PMCs . Positive_regulation PLAU MAA 11853706 913389 We observed that *induces* the increased secretion of [urokinase-type plasminogen activator] , a key component of the plasmin generating system , and that PKC activation is necessary for this enhanced urokinase-type plasminogen activator secretion . Positive_regulation PLAU MAP2K1 11050091 786172 PMA could also activate a signaling pathway involving *dependent* [uPA] expression . Positive_regulation PLAU MAP2K1 11266465 796879 The inhibitor , PD098059 , *blocked* the growth promoting activity of [uPA] and uPA-PAI-1 complex in these cells . Positive_regulation PLAU MAP2K1 11774742 890609 We next asked whether the mechanism of inhibition of uPA expression by bik is due to interference with MAP kinase , since PMA could also activate a signaling pathway involving *dependent* [uPA] expression . Positive_regulation PLAU MAP2K1 12493778 1056696 Further , we show that growth factor induced [uPA] expression *requires* MEKK1 dependent and JNK activity and that transfection of MEKK1 into knockout cells restores inducible uPA expression and activity . Positive_regulation PLAU MAP2K1 14699120 1211598 DN Lck and inhibitors of Lck , EGF receptor , and *suppressed* H/R induced [uPA] secretion and cell motility . Positive_regulation PLAU MAP2K1 14699120 1211602 To our knowledge , this is the first report that p56 ( lck ) in presence of H/R regulates *dependent* ERK1/2 phosphorylation and [uPA] secretion through tyrosine phosphorylation of EGF receptor , and it further demonstrates that all of these signaling molecules ultimately control the motility of breast cancer cells . Positive_regulation PLAU MAP2K1 15743030 1352218 inhibitors ( PD98059 and U0126 ) *inhibited* the production of MMP-2 , MMP-9 and high MW [uPA] , and upregulated TIMPs ( TIMP-1 , TIMP-2 and TIMP-3 ) . Positive_regulation PLAU MAP2K1 18383343 1899169 Inhibitors of Ras ( FTA ) , Raf ( Bay 54-9085 ) and ( UO126 ) , but not of phosphatidylinositol 3-kinase (PI3K) ( LY294002 ) and of protein kinase C ( BIM ) pathways , *inhibited* [uPA] activity and cell invasion . Positive_regulation PLAU MAP2K1 22155455 2542711 [uPA] downregulated PON1 gene expression via inactivation of peroxisome proliferator activated receptor-? ( PPAR? ) activity , and this effect was *dependent* on uPA mediated activation . Positive_regulation PLAU MAP2K2 11266465 796880 The inhibitor , PD098059 , *blocked* the growth promoting activity of [uPA] and uPA-PAI-1 complex in these cells . Positive_regulation PLAU MAP2K2 11774742 890610 We next asked whether the mechanism of inhibition of uPA expression by bik is due to interference with MAP kinase , since PMA could also activate a signaling pathway involving *dependent* [uPA] expression . Positive_regulation PLAU MAP2K2 15743030 1352219 inhibitors ( PD98059 and U0126 ) *inhibited* the production of MMP-2 , MMP-9 and high MW [uPA] , and upregulated TIMPs ( TIMP-1 , TIMP-2 and TIMP-3 ) . Positive_regulation PLAU MAP2K2 18383343 1899170 Inhibitors of Ras ( FTA ) , Raf ( Bay 54-9085 ) and ( UO126 ) , but not of phosphatidylinositol 3-kinase (PI3K) ( LY294002 ) and of protein kinase C ( BIM ) pathways , *inhibited* [uPA] activity and cell invasion . Positive_regulation PLAU MAP2K2 22155455 2542712 [uPA] downregulated PON1 gene expression via inactivation of peroxisome proliferator activated receptor-? ( PPAR? ) activity , and this effect was *dependent* on uPA mediated activation . Positive_regulation PLAU MAP2K3 11266465 796881 The inhibitor , PD098059 , *blocked* the growth promoting activity of [uPA] and uPA-PAI-1 complex in these cells . Positive_regulation PLAU MAP2K3 11774742 890611 We next asked whether the mechanism of inhibition of uPA expression by bik is due to interference with MAP kinase , since PMA could also activate a signaling pathway involving *dependent* [uPA] expression . Positive_regulation PLAU MAP2K3 15743030 1352220 inhibitors ( PD98059 and U0126 ) *inhibited* the production of MMP-2 , MMP-9 and high MW [uPA] , and upregulated TIMPs ( TIMP-1 , TIMP-2 and TIMP-3 ) . Positive_regulation PLAU MAP2K3 15874933 1405760 [uPA] *activation* of PI3K and was EGFR dependent and that of MEK1 was EGFR independent . Positive_regulation PLAU MAP2K3 18383343 1899171 Inhibitors of Ras ( FTA ) , Raf ( Bay 54-9085 ) and ( UO126 ) , but not of phosphatidylinositol 3-kinase (PI3K) ( LY294002 ) and of protein kinase C ( BIM ) pathways , *inhibited* [uPA] activity and cell invasion . Positive_regulation PLAU MAP2K3 22155455 2542713 [uPA] downregulated PON1 gene expression via inactivation of peroxisome proliferator activated receptor-? ( PPAR? ) activity , and this effect was *dependent* on uPA mediated activation . Positive_regulation PLAU MAP2K4 11266465 796882 The inhibitor , PD098059 , *blocked* the growth promoting activity of [uPA] and uPA-PAI-1 complex in these cells . Positive_regulation PLAU MAP2K4 11774742 890612 We next asked whether the mechanism of inhibition of uPA expression by bik is due to interference with MAP kinase , since PMA could also activate a signaling pathway involving *dependent* [uPA] expression . Positive_regulation PLAU MAP2K4 15743030 1352221 inhibitors ( PD98059 and U0126 ) *inhibited* the production of MMP-2 , MMP-9 and high MW [uPA] , and upregulated TIMPs ( TIMP-1 , TIMP-2 and TIMP-3 ) . Positive_regulation PLAU MAP2K4 18383343 1899172 Inhibitors of Ras ( FTA ) , Raf ( Bay 54-9085 ) and ( UO126 ) , but not of phosphatidylinositol 3-kinase (PI3K) ( LY294002 ) and of protein kinase C ( BIM ) pathways , *inhibited* [uPA] activity and cell invasion . Positive_regulation PLAU MAP2K4 22155455 2542714 [uPA] downregulated PON1 gene expression via inactivation of peroxisome proliferator activated receptor-? ( PPAR? ) activity , and this effect was *dependent* on uPA mediated activation . Positive_regulation PLAU MAP2K5 11266465 796883 The inhibitor , PD098059 , *blocked* the growth promoting activity of [uPA] and uPA-PAI-1 complex in these cells . Positive_regulation PLAU MAP2K5 11774742 890613 We next asked whether the mechanism of inhibition of uPA expression by bik is due to interference with MAP kinase , since PMA could also activate a signaling pathway involving *dependent* [uPA] expression . Positive_regulation PLAU MAP2K5 15743030 1352222 inhibitors ( PD98059 and U0126 ) *inhibited* the production of MMP-2 , MMP-9 and high MW [uPA] , and upregulated TIMPs ( TIMP-1 , TIMP-2 and TIMP-3 ) . Positive_regulation PLAU MAP2K5 18383343 1899173 Inhibitors of Ras ( FTA ) , Raf ( Bay 54-9085 ) and ( UO126 ) , but not of phosphatidylinositol 3-kinase (PI3K) ( LY294002 ) and of protein kinase C ( BIM ) pathways , *inhibited* [uPA] activity and cell invasion . Positive_regulation PLAU MAP2K5 22155455 2542715 [uPA] downregulated PON1 gene expression via inactivation of peroxisome proliferator activated receptor-? ( PPAR? ) activity , and this effect was *dependent* on uPA mediated activation . Positive_regulation PLAU MAP2K6 11266465 796884 The inhibitor , PD098059 , *blocked* the growth promoting activity of [uPA] and uPA-PAI-1 complex in these cells . Positive_regulation PLAU MAP2K6 11774742 890614 We next asked whether the mechanism of inhibition of uPA expression by bik is due to interference with MAP kinase , since PMA could also activate a signaling pathway involving *dependent* [uPA] expression . Positive_regulation PLAU MAP2K6 15743030 1352223 inhibitors ( PD98059 and U0126 ) *inhibited* the production of MMP-2 , MMP-9 and high MW [uPA] , and upregulated TIMPs ( TIMP-1 , TIMP-2 and TIMP-3 ) . Positive_regulation PLAU MAP2K6 18383343 1899174 Inhibitors of Ras ( FTA ) , Raf ( Bay 54-9085 ) and ( UO126 ) , but not of phosphatidylinositol 3-kinase (PI3K) ( LY294002 ) and of protein kinase C ( BIM ) pathways , *inhibited* [uPA] activity and cell invasion . Positive_regulation PLAU MAP2K6 22155455 2542716 [uPA] downregulated PON1 gene expression via inactivation of peroxisome proliferator activated receptor-? ( PPAR? ) activity , and this effect was *dependent* on uPA mediated activation . Positive_regulation PLAU MAP2K7 11266465 796885 The inhibitor , PD098059 , *blocked* the growth promoting activity of [uPA] and uPA-PAI-1 complex in these cells . Positive_regulation PLAU MAP2K7 11774742 890615 We next asked whether the mechanism of inhibition of uPA expression by bik is due to interference with MAP kinase , since PMA could also activate a signaling pathway involving *dependent* [uPA] expression . Positive_regulation PLAU MAP2K7 15743030 1352224 inhibitors ( PD98059 and U0126 ) *inhibited* the production of MMP-2 , MMP-9 and high MW [uPA] , and upregulated TIMPs ( TIMP-1 , TIMP-2 and TIMP-3 ) . Positive_regulation PLAU MAP2K7 18383343 1899175 Inhibitors of Ras ( FTA ) , Raf ( Bay 54-9085 ) and ( UO126 ) , but not of phosphatidylinositol 3-kinase (PI3K) ( LY294002 ) and of protein kinase C ( BIM ) pathways , *inhibited* [uPA] activity and cell invasion . Positive_regulation PLAU MAP2K7 22155455 2542717 [uPA] downregulated PON1 gene expression via inactivation of peroxisome proliferator activated receptor-? ( PPAR? ) activity , and this effect was *dependent* on uPA mediated activation . Positive_regulation PLAU MAP3K1 12493778 1056691 is *required* for inducible [urokinase-type plasminogen activator] expression . Positive_regulation PLAU MAP3K1 12493778 1056697 Further , we show that growth factor induced uPA expression requires MEKK1 dependent MKK1 and JNK activity and that transfection of into knockout cells *restores* inducible [uPA] expression and activity . Positive_regulation PLAU MAP3K1 16568086 1598085 signaling regulates migration through control of cell adhesion and is *required* for inducible expression of [urokinase-type plasminogen activator] ( uPA ) . Positive_regulation PLAU MAP3K2 12493778 1056698 Importantly , disrupted expression of , a related MAPK kinase kinase , *had* no effect on [uPA] activity . Positive_regulation PLAU MAPK1 10537311 563195 Regulation by p38 of adenylate- and uridylate-rich element *mediated* [urokinase-type plasminogen activator] ( uPA ) messenger RNA stability and uPA dependent in vitro cell invasion . Positive_regulation PLAU MAPK1 10766865 684615 [Urokinase plasminogen activator/urokinase-specific] surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha activity . Positive_regulation PLAU MAPK1 10766865 684642 Finally , by selectively inhibiting p38alpha or p38beta MAPK isoforms , we demonstrate that p38alpha , rather than p38beta , activity is *essential* for [uPA/uPAR] expression . Positive_regulation PLAU MAPK1 11050091 786173 PMA could also activate a signaling pathway involving *dependent* [uPA] expression . Positive_regulation PLAU MAPK1 11820789 908832 Induction of [uPA] but not NF-IL3A by calcitonin is *dependent* on phosphorylation in porcine renal cell line LLC-PK1 . Positive_regulation PLAU MAPK1 20467333 2268923 Small-molecule inhibitors of , tyrosine kinase , and small interfering RNA targeting c-Src *blocked* [uPA] upregulation . Positive_regulation PLAU MAPK10 10537311 563196 Regulation by p38 of adenylate- and uridylate-rich element *mediated* [urokinase-type plasminogen activator] ( uPA ) messenger RNA stability and uPA dependent in vitro cell invasion . Positive_regulation PLAU MAPK10 10766865 684616 [Urokinase plasminogen activator/urokinase-specific] surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha activity . Positive_regulation PLAU MAPK10 10766865 684643 Finally , by selectively inhibiting p38alpha or p38beta MAPK isoforms , we demonstrate that p38alpha , rather than p38beta , activity is *essential* for [uPA/uPAR] expression . Positive_regulation PLAU MAPK10 20467333 2268924 Small-molecule inhibitors of , tyrosine kinase , and small interfering RNA targeting c-Src *blocked* [uPA] upregulation . Positive_regulation PLAU MAPK11 10537311 563197 Regulation by p38 of adenylate- and uridylate-rich element *mediated* [urokinase-type plasminogen activator] ( uPA ) messenger RNA stability and uPA dependent in vitro cell invasion . Positive_regulation PLAU MAPK11 10766865 684617 [Urokinase plasminogen activator/urokinase-specific] surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha activity . Positive_regulation PLAU MAPK11 10766865 684644 Finally , by selectively inhibiting p38alpha or p38beta MAPK isoforms , we demonstrate that p38alpha , rather than p38beta , activity is *essential* for [uPA/uPAR] expression . Positive_regulation PLAU MAPK11 20467333 2268925 Small-molecule inhibitors of , tyrosine kinase , and small interfering RNA targeting c-Src *blocked* [uPA] upregulation . Positive_regulation PLAU MAPK12 10537311 563198 Regulation by p38 of adenylate- and uridylate-rich element *mediated* [urokinase-type plasminogen activator] ( uPA ) messenger RNA stability and uPA dependent in vitro cell invasion . Positive_regulation PLAU MAPK12 10766865 684618 [Urokinase plasminogen activator/urokinase-specific] surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha activity . Positive_regulation PLAU MAPK12 10766865 684645 Finally , by selectively inhibiting p38alpha or p38beta MAPK isoforms , we demonstrate that p38alpha , rather than p38beta , activity is *essential* for [uPA/uPAR] expression . Positive_regulation PLAU MAPK12 20467333 2268926 Small-molecule inhibitors of , tyrosine kinase , and small interfering RNA targeting c-Src *blocked* [uPA] upregulation . Positive_regulation PLAU MAPK13 10537311 563199 Regulation by p38 of adenylate- and uridylate-rich element *mediated* [urokinase-type plasminogen activator] ( uPA ) messenger RNA stability and uPA dependent in vitro cell invasion . Positive_regulation PLAU MAPK13 10766865 684619 [Urokinase plasminogen activator/urokinase-specific] surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha activity . Positive_regulation PLAU MAPK13 10766865 684646 Finally , by selectively inhibiting p38alpha or p38beta MAPK isoforms , we demonstrate that p38alpha , rather than p38beta , activity is *essential* for [uPA/uPAR] expression . Positive_regulation PLAU MAPK13 20467333 2268927 Small-molecule inhibitors of , tyrosine kinase , and small interfering RNA targeting c-Src *blocked* [uPA] upregulation . Positive_regulation PLAU MAPK14 10537311 563200 Regulation by p38 of adenylate- and uridylate-rich element *mediated* [urokinase-type plasminogen activator] ( uPA ) messenger RNA stability and uPA dependent in vitro cell invasion . Positive_regulation PLAU MAPK14 10766865 684620 [Urokinase plasminogen activator/urokinase-specific] surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha activity . Positive_regulation PLAU MAPK14 10766865 684647 Finally , by selectively inhibiting p38alpha or p38beta MAPK isoforms , we demonstrate that p38alpha , rather than p38beta , activity is *essential* for [uPA/uPAR] expression . Positive_regulation PLAU MAPK14 20467333 2268928 Small-molecule inhibitors of , tyrosine kinase , and small interfering RNA targeting c-Src *blocked* [uPA] upregulation . Positive_regulation PLAU MAPK15 10537311 563194 Regulation by p38 of adenylate- and uridylate-rich element *mediated* [urokinase-type plasminogen activator] ( uPA ) messenger RNA stability and uPA dependent in vitro cell invasion . Positive_regulation PLAU MAPK15 10766865 684613 [Urokinase plasminogen activator/urokinase-specific] surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha activity . Positive_regulation PLAU MAPK15 10766865 684641 Finally , by selectively inhibiting p38alpha or p38beta MAPK isoforms , we demonstrate that p38alpha , rather than p38beta , activity is *essential* for [uPA/uPAR] expression . Positive_regulation PLAU MAPK15 20467333 2268922 Small-molecule inhibitors of , tyrosine kinase , and small interfering RNA targeting c-Src *blocked* [uPA] upregulation . Positive_regulation PLAU MAPK3 10393815 627252 Nevertheless , a sustained activation is not *sufficient* to trigger [uPA] upregulation and morphogenesis . Positive_regulation PLAU MAPK3 10508858 650812 These results indicate that dormancy of low uPAR cells may be the consequence of insufficient [uPA/uPAR/alpha5beta1] complexes , which can not *induce* activity above a threshold needed to sustain tumor growth in vivo . Positive_regulation PLAU MAPK3 10537311 563201 Regulation by p38 of adenylate- and uridylate-rich element *mediated* [urokinase-type plasminogen activator] ( uPA ) messenger RNA stability and uPA dependent in vitro cell invasion . Positive_regulation PLAU MAPK3 10766865 684621 [Urokinase plasminogen activator/urokinase-specific] surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha activity . Positive_regulation PLAU MAPK3 10766865 684648 Finally , by selectively inhibiting p38alpha or p38beta MAPK isoforms , we demonstrate that p38alpha , rather than p38beta , activity is *essential* for [uPA/uPAR] expression . Positive_regulation PLAU MAPK3 11820789 908833 Induction of [uPA] but not NF-IL3A by calcitonin is *dependent* on phosphorylation in porcine renal cell line LLC-PK1 . Positive_regulation PLAU MAPK3 14699120 1211591 However , the role of hypoxia/reoxygenation ( H/R ) on *mediated* [uPA] secretion and cell motility and the involvement of p56 ( lck ) and EGF receptor in these processes in breast cancer cells is not well defined . Positive_regulation PLAU MAPK3 17581316 1764129 STI571 may therefore influence many aspects of tumor cell biology through inducing [urokinase-type plasminogen activator] and interleukin-8 , in which the induction of early growth response-1 expression and phosphorylation might be *involved* . Positive_regulation PLAU MAPK3 19184369 2049336 After administration of inhibitors including U0126 ( ERK1/2 inhibitor ) , SB203580 ( p38 MAPK inhibitor ) , SP600125 ( JNK1/2 inhibitor ) , CsA ( calcineurin inhibitor ) , and QNZ ( NFkappaB inhibitor ) , the LPS upregulated expression and/or activity of [uPA] , MMP-2 , and MMP-9 in H9c2 cardiomyoblasts are markedly *inhibited* only by inhibitors , U0126 . Positive_regulation PLAU MAPK3 20467333 2268929 Small-molecule inhibitors of , tyrosine kinase , and small interfering RNA targeting c-Src *blocked* [uPA] upregulation . Positive_regulation PLAU MAPK4 10537311 563202 Regulation by p38 of adenylate- and uridylate-rich element *mediated* [urokinase-type plasminogen activator] ( uPA ) messenger RNA stability and uPA dependent in vitro cell invasion . Positive_regulation PLAU MAPK4 10766865 684622 [Urokinase plasminogen activator/urokinase-specific] surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha activity . Positive_regulation PLAU MAPK4 10766865 684649 Finally , by selectively inhibiting p38alpha or p38beta MAPK isoforms , we demonstrate that p38alpha , rather than p38beta , activity is *essential* for [uPA/uPAR] expression . Positive_regulation PLAU MAPK4 20467333 2268930 Small-molecule inhibitors of , tyrosine kinase , and small interfering RNA targeting c-Src *blocked* [uPA] upregulation . Positive_regulation PLAU MAPK6 10537311 563203 Regulation by p38 of adenylate- and uridylate-rich element *mediated* [urokinase-type plasminogen activator] ( uPA ) messenger RNA stability and uPA dependent in vitro cell invasion . Positive_regulation PLAU MAPK6 10766865 684623 [Urokinase plasminogen activator/urokinase-specific] surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha activity . Positive_regulation PLAU MAPK6 10766865 684650 Finally , by selectively inhibiting p38alpha or p38beta MAPK isoforms , we demonstrate that p38alpha , rather than p38beta , activity is *essential* for [uPA/uPAR] expression . Positive_regulation PLAU MAPK6 20467333 2268931 Small-molecule inhibitors of , tyrosine kinase , and small interfering RNA targeting c-Src *blocked* [uPA] upregulation . Positive_regulation PLAU MAPK7 10537311 563204 Regulation by p38 of adenylate- and uridylate-rich element *mediated* [urokinase-type plasminogen activator] ( uPA ) messenger RNA stability and uPA dependent in vitro cell invasion . Positive_regulation PLAU MAPK7 10766865 684624 [Urokinase plasminogen activator/urokinase-specific] surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha activity . Positive_regulation PLAU MAPK7 10766865 684651 Finally , by selectively inhibiting p38alpha or p38beta MAPK isoforms , we demonstrate that p38alpha , rather than p38beta , activity is *essential* for [uPA/uPAR] expression . Positive_regulation PLAU MAPK7 20467333 2268932 Small-molecule inhibitors of , tyrosine kinase , and small interfering RNA targeting c-Src *blocked* [uPA] upregulation . Positive_regulation PLAU MAPK8 10537311 563205 Regulation by p38 of adenylate- and uridylate-rich element *mediated* [urokinase-type plasminogen activator] ( uPA ) messenger RNA stability and uPA dependent in vitro cell invasion . Positive_regulation PLAU MAPK8 10766865 684625 [Urokinase plasminogen activator/urokinase-specific] surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha activity . Positive_regulation PLAU MAPK8 10766865 684652 Finally , by selectively inhibiting p38alpha or p38beta MAPK isoforms , we demonstrate that p38alpha , rather than p38beta , activity is *essential* for [uPA/uPAR] expression . Positive_regulation PLAU MAPK8 20467333 2268933 Small-molecule inhibitors of , tyrosine kinase , and small interfering RNA targeting c-Src *blocked* [uPA] upregulation . Positive_regulation PLAU MAPK8 21859479 2486421 We further observed that 17ß-estradiol treatment *inhibited* PGE2 induced [uPA] , MMP-9 and cellular motility by suppressing activation of in human LoVo cancer cells . Positive_regulation PLAU MAPK9 10537311 563206 Regulation by p38 of adenylate- and uridylate-rich element *mediated* [urokinase-type plasminogen activator] ( uPA ) messenger RNA stability and uPA dependent in vitro cell invasion . Positive_regulation PLAU MAPK9 10766865 684626 [Urokinase plasminogen activator/urokinase-specific] surface receptor expression and matrix invasion by breast cancer cells *requires* constitutive p38alpha activity . Positive_regulation PLAU MAPK9 10766865 684653 Finally , by selectively inhibiting p38alpha or p38beta MAPK isoforms , we demonstrate that p38alpha , rather than p38beta , activity is *essential* for [uPA/uPAR] expression . Positive_regulation PLAU MAPK9 20467333 2268934 Small-molecule inhibitors of , tyrosine kinase , and small interfering RNA targeting c-Src *blocked* [uPA] upregulation . Positive_regulation PLAU MBTPS1 19147534 2026256 *induced* expression of [uPA] and its receptor , uPAR , in GBM cells . Positive_regulation PLAU MDM2 15937335 1434021 However , [uPA] *induced* in a concentration dependent manner . Positive_regulation PLAU MED1 8814143 383492 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED10 8814143 383488 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED11 8814143 383491 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED12 8814143 383463 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED13 8814143 383473 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED13L 8814143 383474 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED14 8814143 383478 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED15 8814143 383464 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED16 8814143 383467 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED17 8814143 383480 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED18 8814143 383487 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED19 8814143 383490 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED20 8814143 383466 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED21 8814143 383461 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED22 8814143 383462 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED23 8814143 383479 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED24 8814143 383475 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED25 8814143 383489 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED26 8814143 383481 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED27 8814143 383482 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED28 8814143 383485 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED29 8814143 383477 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED30 8814143 383476 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED31 8814143 383484 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED4 8814143 383469 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED6 8814143 383471 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED7 8814143 383483 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED8 8814143 383472 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MED9 8814143 383486 To determine whether platelet activating factor (PAF) , a lipid that is accumulated in the cornea after alkali burn , *induces* the gene expression of [urokinase-type plasminogen activator] ( uPA ) in the corneal epithelium . Positive_regulation PLAU MET 12958170 1138187 Here we provide evidence that PGE2 transactivates ( contingent upon functional EGFR ) , increases tyrosine phosphorylation and nuclear accumulation of beta-catenin , and *induces* [urokinase-type plasminogen activator] receptor ( uPAR ) mRNA expression . Positive_regulation PLAU MET 17992475 1860060 *Role* of hepatocyte growth signaling in regulating [urokinase plasminogen activator] on invasiveness in human hepatocellular carcinoma : a potential therapeutic target . Positive_regulation PLAU MET 8622656 354391 A strong correlation has previously been demonstrated between the activation of the urokinase plasminogen activator (uPA) proteolysis network and the acquisition of the invasive-metastatic phenotype , and we show here that signalling significantly *increases* the protein levels of both [uPA] and its cellular receptor in SK-LMS-1 cells . Positive_regulation PLAU MET 9038378 415572 We found that efficiently *activates* the [uPA] gene via a SOS/Ras/extracellular signal regulated kinase ( ERK ) -dependent signaling pathway . Positive_regulation PLAU MET 9038378 415573 Mutation of Y1356 , which abrogates GRB2 binding , reduced the induction to half of the control level , while mutation of Y1349 showed little effect on uPA induction , suggesting an important but partly replaceable role for GRB2 in *dependent* [uPA] gene induction . Positive_regulation PLAU MFI2 16979249 1628097 We have recently demonstrated , that truncated human recombinant soluble ( sMTf ) could *stimulate* the activation of Plg by [urokinase plasminogen activator] and inhibit angiogenesis . Positive_regulation PLAU MMP14 19861500 2160653 We demonstrate here , that the collagen internalisation receptor Endo180 ( also known as CD280 , uPARAP , MRC2 ) is a novel regulator of membrane bound matrix metalloproteinase ( MT1-MMP ) activity , *dependent* MMP-2 activation and [urokinase plasminogen activator (uPA)] activity . Positive_regulation PLAU MMP14 9853262 554903 In addition , when the conditioned medium was successively incubated with uPA and alpha 2-macroglobulin and analyzed by immunoblotting , MT1-MMP decreased , indicating that the soluble was in a latent form and was *activated* by [uPA] . Positive_regulation PLAU MMP2 12761886 1091762 In conclusion , these data suggest that genistein , apigenin , and 3-hydroxyflavone inhibit in vitro angiogenesis , in part via preventing VEGF/bFGF induced MMP-1 and [uPA] expression and the *activation* of , and via modulating their inhibitors , TIMP-1 and -2 , and PAI-1 . Positive_regulation PLAU MMP2 14598319 1161235 Both tPA and uPA activate some matrix metalloproteases ( MMPs ) , indirectly via plasminogen activation or directly , such as the [uPA] *activation* of . Positive_regulation PLAU MMP2 16554301 1562043 2 ) activation of plasminogen by [uPA] and subsequent *activation* of transforming growth factor-beta1 ( TGF-beta1 ) and and -9 by plasmin are critical pathways through which uPA expressing macrophages accumulate in the heart and cause fibrosis ; Positive_regulation PLAU MMP3 10406070 629371 Conversely , steroid withdrawal elicited increases in [uPA] , MMP-1 and activities would *promote* endometrial sloughing by degrading the mixture of decidual cell derived basement membrane-like proteins and interstitial components that comprise the stromal ECM of the perimenstrual endometrium . Positive_regulation PLAU MMP9 16554301 1562044 2 ) activation of plasminogen by [uPA] and subsequent *activation* of transforming growth factor-beta1 ( TGF-beta1 ) and by plasmin are critical pathways through which uPA expressing macrophages accumulate in the heart and cause fibrosis ; Positive_regulation PLAU MMP9 20736374 2313455 *augmented* [uPA] activity in the medium of PC3-ML cells by degrading PN-1 . Positive_regulation PLAU MMP9 20736374 2313456 This study shows a novel molecular pathway in which *regulates* [uPA] activity and tumor cell invasion through cleavage of PN-1 . Positive_regulation PLAU MYC 17382917 1748436 is *essential* for [urokinase plasminogen activator] expression on hypoxia induced vascular smooth muscle cells . Positive_regulation PLAU MYC 17382917 1748437 The results show that was *essential* for hypoxia induced [uPA] expression and activity , resulting in VSMC migration and invasion . Positive_regulation PLAU MYLIP 21779487 2457005 uPA mRNA was a direct target of and miR-181a , and a higher [uPA] level in cells with impaired miRNA processing *resulted* from less mature miR-193a/b and miR-181a processed from their respective primary miRNAs . Positive_regulation PLAU NA 7957773 278100 TNF alpha increased the steady state level of [urokinase-type plasminogen activator] ( uPA ) , and *inhibited* this increase at a dose that also inhibited the increase in the intracellular oxidation state . Positive_regulation PLAU NFKB1 11689575 903858 The urokinase-type plasminogen activator ( uPA ) promoter contains an NF-kappaB binding site , and [uPA] expression in MDA-MB-231 cells is *induced* by the constitutively active . Positive_regulation PLAU NFKB1 11689575 903867 Furthermore , inhibition of markedly attenuated endogenous migration , and inhibition of PI 3-kinase and NF-kappaB *reduced* secretion of [uPA] . Positive_regulation PLAU NFKB1 12477728 1056098 To our knowledge , this is the first report that Syk suppresses the cell motility and *inhibits* the PI 3'-kinase activity and [uPA] secretion by blocking activity through tyrosine phosphorylation of I kappa B alpha . Positive_regulation PLAU NFKB1 14534291 1174984 Luciferase reporter gene assay indicated that Lck induces *dependent* [urokinase type plasminogen activator] ( uPA ) promoter activity in presence of H/R . Positive_regulation PLAU NFKB1 16109653 1445276 To evaluate the *role* of transcription factor in [uPA] and uPAR gene transcription with H. pylori stimulation , the effect of NF-kappaB inhibitor MG132 on H. pylori induced uPA and uPAR mRNA expression was examined . Positive_regulation PLAU NFKB1 16340751 1504031 Subsequently , the EGF induced MMP-9 and [uPA] expression and MMP-9 activity , as well as cell invasiveness , were also *inhibited* by these inhibitors . Positive_regulation PLAU NFKB1 16691505 1560382 Taken together , NIK acts as crucial regulator in OPN induced MAPK/IKK mediated *dependent* [uPA] secretion and MMP-9 activation thereby controlling melanoma cell motility and chemoinvasion . Positive_regulation PLAU NFKB1 17510309 1745187 SN50 , a specific inhibitor of , which could inhibit in vitro invasive and migratory abilities of gastric cancer cells , *reduced* expression of [uPA] and MMP9 proteins and increased expression of TIMP1 protein . Positive_regulation PLAU NFKB1 17571974 1763285 Expression of [uPA] is *regulated* in part by the oxidant-sensitive transcription factor , , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Positive_regulation PLAU NFKB1 18478929 1840487 Subsequently , the EGF induced [uPA] expression and invasiveness were also *inhibited* by inhibitor . Positive_regulation PLAU NFKB1 18478929 1840489 Our findings indicated that *mediated* up-regulation of [uPA] expression is responsible for EGF induced invasiveness in pancreatic cancer cells , and implicate that such anti-NF-kappaB therapy with NF-kappaB inhibitors may contribute to the reduction of invasiveness of pancreatic cancer . Positive_regulation PLAU NFKB1 1905804 161659 Our results suggest that maximal transcriptional activation of the [uPA] gene by PMA , IL-1 and TNF alpha *requires* the induction of activity and the decay of a short lived repressor protein , possibly IkB . Positive_regulation PLAU NFKB1 19165610 2038429 The BRMS1 metastasis suppressor was recently shown to negatively regulate NF-kappaB signaling and down regulate *dependent* [uPA] expression . Positive_regulation PLAU NFKB1 19303700 2064332 Inhibition of activity significantly reduced proliferation and invasion of Hep3B cells as well as *down-regulated* the expression of invasion related molecules including matrix metalloproteinase (MMP)-2 , MMP-9 , membrane type-1 MMP (MT1-MMP) , [urokinase plasminogen activator (uPA)] and vascular endothelial growth factor ( VEGF ) . Positive_regulation PLAU NFKB1 20204677 2272547 Our results shows that TGF-beta1 stimulation of [uPA] and MMP-9 expression *involve* NOXs dependent ROS and , activation , demonstrated by using DPI , NOXs inhibitor , ROS scavenger N-acetylcysteine and SN50 , an NFkb inhibitor . Positive_regulation PLAU NFKB1 20204677 2272559 Thus , *acts* as the crucial signal in TGF-beta1 induced [uPA] and MMP-9 expression thereby mediating the enhancement of cellular malignity by TGF-beta1 . Positive_regulation PLAU NFKB1 20502321 2301209 *dependent* regulation of [urokinase plasminogen activator] by proanthocyanidin-rich grape seed extract : effect on invasion by prostate cancer cells . Positive_regulation PLAU NFKB1 20502321 2301213 Additional studies showed that GSE inhibited DNA binding activity of the transcription factor nuclear factor kappa B (NFkappaB) , which in turn decreased *dependent* [uPA] transcription . Positive_regulation PLAU NFKB1 8804426 382181 Using the protein synthesis inhibitor cycloheximide and the antioxidant PDTC , that have an opposite effect on NF-kappa B and AP-1 activation , we showed that [uPA] mRNA induction by TNF-alpha and PMA in the A549 cell line is mainly *due* to activation . Positive_regulation PLAU NGF 10627600 659184 The [urokinase plasminogen activator] receptor ( UPAR ) is preferentially *induced* by in PC12 pheochromocytoma cells and is required for NGF-driven differentiation . Positive_regulation PLAU NGF 10905620 713695 preferentially *induces* the [urokinase-plasminogen activator] receptor in PC12 cells . Positive_regulation PLAU NGF 21486950 2417727 Release of SH2B1ß from the PM and/or nuclear entry appear to be required for SH2B1ß enhancement of *induced* expression of [urokinase plasminogen activator] receptor gene and neurite outgrowth of PC12 cells . Positive_regulation PLAU NGF 8393859 227996 *activates* soluble and receptor bound single chain [urokinase-type plasminogen activator] . Positive_regulation PLAU NPR2 21395696 2438302 efficiently *activated* human [pro-urokinase plasminogen activator] ( pro-uPA ) , a key protein in the fibrinolytic cascade . Positive_regulation PLAU NRAS 18383343 1899176 Inhibitors of ( FTA ) , Raf ( Bay 54-9085 ) and MEK ( UO126 ) , but not of phosphatidylinositol 3-kinase (PI3K) ( LY294002 ) and of protein kinase C ( BIM ) pathways , *inhibited* [uPA] activity and cell invasion . Positive_regulation PLAU NTS 9428741 474310 To investigate if could *induce* activation of [urokinase-type plasminogen activator] ( uPA ) in vascular endothelial cells , we utilized the acetyl-NT ( 8-13 ) analogue , TJN-950 , in which the C-terminal leucine is reduced to leucinol . Positive_regulation PLAU NUP43 17611702 1768676 Specific inhibitors were utilized to determine if interference with the p38 ( MAPK ) , ( MAPK ) , and PI3K pathways functionally *blocked* LPA mediated [uPA] secretion . Positive_regulation PLAU OSM 10967551 728299 *stimulated* increased mRNA levels of [urokinase-plasminogen activator (uPA)] and urokinase-plasminogen activator receptor ( uPAR ) in a time and dose dependent manner . Positive_regulation PLAU OSM 1953736 172343 *stimulates* [urokinase-type plasminogen activator] activity in human synovial fibroblasts . Positive_regulation PLAU PAF1 15149885 1248449 Activation of receptor by oxidised LDL in human monocytes *stimulates* chemokine releases but not [urokinase-type plasminogen activator] expression . Positive_regulation PLAU PAF1 15149885 1248468 Our results indicated that oxidation products are responsible for the monocyte chemokine releases , but did not *contribute* to the enhanced monocyte [uPA] expression by oxidised LDL . Positive_regulation PLAU PAF1 9185044 436695 We have found that in the cornea , a potent lipid inflammatory mediator *activates* the expression of two metalloproteinases ( MMP-1 and MMP-9 ) as well as [urokinase-plasminogen activator (uPA)] . Positive_regulation PLAU PAICS 8977672 403443 Cell bound [uPA] is *regulated* by . Positive_regulation PLAU PBK 15880258 1406199 Co-transfection of pEGFP-C3-PBK1 and the deletion mutants of the pGL3-uPA promoter indicated that can *increase* the [uPA] promoter activity by about 25 % and this effect is uPA enhancer dependent . Positive_regulation PLAU PDGFB 15223783 1264798 *increased* [uPA] gene expression and fibrinolytic activity . Positive_regulation PLAU PGF 10886518 709838 Similarly , did not *induce* [urokinase-type plasminogen activator] production in these cells . Positive_regulation PLAU PI3 11689575 903868 Furthermore , inhibition of NF-kappaB markedly attenuated endogenous migration , and inhibition of and NF-kappaB *reduced* secretion of [uPA] . Positive_regulation PLAU PI3 12771144 1113360 To our knowledge , this is first report that OPN induces NFkappaB activity and uPA secretion by activating PI 3'-kinase/Akt/IKK mediated signaling pathways and further demonstrates a functional molecular link between OPN induced *dependent* Akt phosphorylation and NFkappaB mediated [uPA] secretion , and all of these ultimately control the motility of breast cancer cells . Positive_regulation PLAU PIK3CA 15874933 1405761 [uPA] *activation* of and MKK3/6 was EGFR dependent and that of MEK1 was EGFR independent . Positive_regulation PLAU PIK3R1 15874933 1405762 [uPA] *activation* of and MKK3/6 was EGFR dependent and that of MEK1 was EGFR independent . Positive_regulation PLAU PKD2 22797919 2706082 These results were further substantiated by the finding that and PKD3 *promoted* the activity of [uPA] and matrix metalloproteinase 9 (MMP9) . Positive_regulation PLAU PKD3 22797919 2706083 These results were further substantiated by the finding that PKD2 and *promoted* the activity of [uPA] and matrix metalloproteinase 9 (MMP9) . Positive_regulation PLAU PLAT 10086616 599647 The [urokinase-type plasminogen activator] ( uPA ) could be *detected* in the basal stratum of the cholesteatoma matrix and in the surrounding granulation tissue , while ( tPA ) was not detectable at all . Positive_regulation PLAU PLAT 16313928 1526168 The expression of increased greatly during the proliferative stage of culture , and [uPA] expression *increased* throughout the culture period , increasing markedly from the proliferative to the later stages of culture . Positive_regulation PLAU PLAT 17134505 1661453 Absence of uPAR alone or the combined absence of uPAR and had no impact on the resolution of centrilobular injury , but the loss of receptor-free [uPA] significantly *impaired* the clearance of necrotic hepatocytes up to 14 days after CCl4 . Positive_regulation PLAU PLAT 18042398 1846622 During the critical 1-2 h delay period required for this synaptic plasticity following a C2 hemisection in mice , [uPA] and tPA mRNAs are rapidly *induced* in C4-5 ventral spinal cord neurons in the ipsilateral phrenic motor nucleus ( PMN ) , as are uPA and protein levels . Positive_regulation PLAU PLAT 1918136 168368 In three of these five cell lines , this process was *mediated* by and in the other two cell lines by [urokinase-type plasminogen activator] ( u-PA ) . Positive_regulation PLAU PLAT 22918041 2693106 Plasma *increases* fibrinolytic activity of exogenous [urokinase-type plasminogen activator] . Positive_regulation PLAU PLAT 8119140 250592 Interestingly , whereas mRNA levels , like those of TGF beta 2 and -beta 3 , were barely detectable in adult prostatic tissues , mRNA levels for [urokinase plasminogen activator] , androgen receptor , and c-myc were readily *detected* and expressed in a lobe-specific fashion . Positive_regulation PLAU PLAU 9249034 446552 The ( 1-281 ) -peptide complex and tc-uPA also showed a similar extent of plasminogen activation as measured by SDS/PAGE , when incubated with plasminogen and Spl in the presence of 100 micro M aprotinin , and plasminogen activation by [pro-uPA] alone was also *stimulated* in the presence of Spl in this assay . Positive_regulation PLAU PLAUR 10090848 600278 Additionally , antisense inhibition *induced* a 68-70 % reduction in [uPA] and plasmin activities . Positive_regulation PLAU PLAUR 11359936 816717 Here we investigated whether direct interaction between , a glycosyl-phosphatidylinositol anchored protein , and LRP , a transmembrane receptor , is *required* for clearance of [uPA] : PAI-1 , regeneration of unoccupied uPAR , activation of plasminogen , and the ability of HT1080 cells to invade extracellular matrix . Positive_regulation PLAU PLAUR 11818541 908612 In this article we show that ( i ) both and FPRL1/LXA4R are *necessary* for the chemotactic activity of [uPA] whereas FPRL1/LXA4R is sufficient to mediate D2D3 ( 88-274 ) -induced cell migration . Positive_regulation PLAU PLAUR 12754207 1113093 [uPA] signaling *requires* its binding to uPA receptor ( ) , but how glycosylphosphatidylinositol anchored uPAR mediates signaling is unclear . Positive_regulation PLAU PLAUR 12754207 1113097 We demonstrated that [uPA] *induced* RGD dependent binding of to alpha 5 beta 1 in solution . Positive_regulation PLAU PLAUR 16140945 1450933 We investigated the hypotheses that ( a ) insulin-like growth factor-I (IGF-I)- and hepatocyte growth factor (HGF) mediated migration and invasion of human pancreatic carcinoma cells require [uPA] and uPAR function and ( b ) inhibition of *inhibits* tumor growth , retroperitoneal invasion , and hepatic metastasis of human pancreatic carcinomas in mice . Positive_regulation PLAU PLAUR 16391791 1505822 Furthermore , [uPA-treatment] significantly *induced* the expression of plasmin(ogen) and in the conditioned medium of non dissociated ( PC-1 ) pancreatic cancer cells . Positive_regulation PLAU PLAUR 16618739 1551073 The maspin effects on surface associated [uPA] and uPAR *required* the interaction between uPA and . Positive_regulation PLAU PLAUR 16923171 1603119 Over-expression of [uPA] in the VTA *induces* doxycycline dependent expression of its receptor , , but not its inhibitor , plasminogen activator inhibitor-1 ( PAI-1 ) . Positive_regulation PLAU PLAUR 17134505 1661447 Based on the efficient activation of plasminogen when uPA is bound to its receptor (uPAR) and on the role of uPA in plasmin mediated liver repair , we hypothesized that [uPA] *requires* for efficient liver repair . Positive_regulation PLAU PLAUR 17134505 1661454 Absence of uPAR alone or the combined absence of and tPA had no impact on the resolution of centrilobular injury , but the loss of receptor-free [uPA] significantly *impaired* the clearance of necrotic hepatocytes up to 14 days after CCl4 . Positive_regulation PLAU PLAUR 17186542 1701676 These results indicate that expression of *requires* [uPA] but not vice versa . Positive_regulation PLAU PLAUR 17344041 1740993 Our results indicate that vitronectin dependent localization of [uPA] to adhesion sites *requires* the sequential binding of vitronectin integrins and to vitronectin . Positive_regulation PLAU PLAUR 17992475 1860065 HGF enhanced the protein level and the activity of [uPA] in HepG2 and Hep3B cells , and the protein level also *increased* in a HGF dose dependent manner . Positive_regulation PLAU PLAUR 19029002 2029309 Biological activities of [uPA] , including proteolysis , cell adhesion , migration , proliferation , and differentiation , are *dependent* on its association with . Positive_regulation PLAU PLAUR 19377974 2065622 Here , we describe the use of PrAg-U2 as a molecular reporter tool to test the controversial question of what components are required for mediated cell surface [pro-uPA] *activation* . Positive_regulation PLAU PLAUR 21573407 243080 Additionally , [uPA receptors (uPA-R)] could be *detected* in HL-60 on both the mRNA and the protein level , whereas the lymphoblastic cell line Raji studied in parallel was negative . Positive_regulation PLAU PLAUR 21783479 1506643 The herbicide Roundup and insecticides Lorsban and Warrior *induced* [uPA] while Lorsban and Warrior also induced . Positive_regulation PLAU PLAUR 22013113 2503312 These data suggested that binding of anti-Ro Abs to apoptotic cardiocytes triggers TGF-ß activation , by virtue of increasing *dependent* [uPA] activity , thus initiating and amplifying a cascade of events that promotes myofibroblast transdifferentiation and scar . Positive_regulation PLAU PLAUR 23060546 2685565 MDSC can be recruited by [uPA] , and but not CD11b are *required* for such recruitment . Positive_regulation PLAU PLAUR 23238745 2736696 We now demonstrate that overexpression induces or *increases* [uPA] secretion both in uPAR negative and in uPAR expressing cells . Positive_regulation PLAU PLAUR 23238745 2736697 These findings demonstrate that , whose expression is regulated by uPA , can , in turn , *regulate* [uPA] expression through a mechanism involving its functional interaction with integrins and fMLF-Rs . Positive_regulation PLAU PLAUR 24125407 2853230 The antiapoptotic activity of [uPA] was *dependent* on the presence of , and it involved ERK1/2 activation dependent downregulation of the proapoptotic protein Bim in macrophages stimulated with Ox-LDL . Positive_regulation PLAU PLAUR 8662951 367698 Soluble also *caused* no increase in the low , but discernible , intrinsic activity of [pro-uPA] . Positive_regulation PLAU PLAUR 9249034 446553 The ( 1-281 ) -peptide complex and tc-uPA also showed a similar extent of plasminogen activation as measured by SDS/PAGE , when incubated with plasminogen and Spl in the presence of 100 micro M aprotinin , and plasminogen activation by [pro-uPA] alone was also *stimulated* in the presence of Spl in this assay . Positive_regulation PLAU PLAUR 9848876 554081 These data suggest that [uPA] stimulates adhesion of SMCs specifically to vitronectin and that it is *mediated* by an interaction with . Positive_regulation PLAU PLCG1 8940113 398946 Induction of [urokinase-type plasminogen activator] by fibroblast growth factor (FGF)-2 is dependent on expression of FGF receptors and does not *require* activation of . Positive_regulation PLAU PLD1 12458339 1021597 Src/ERK but not is *involved* in keratinocyte growth factor stimulated secretion of matrix metalloprotease-9 and [urokinase-type plasminogen activator] in SNU-16 human stomach cancer cell . Positive_regulation PLAU PLD1 9150275 430220 These results suggest for the first time that [uPA] production is *regulated* by and PKC signal transduction pathways in murine mammary adenocarcinoma cells . Positive_regulation PLAU PLD2 12458339 1021598 Src/ERK but not is *involved* in keratinocyte growth factor stimulated secretion of matrix metalloprotease-9 and [urokinase-type plasminogen activator] in SNU-16 human stomach cancer cell . Positive_regulation PLAU PLD2 9150275 430221 These results suggest for the first time that [uPA] production is *regulated* by and PKC signal transduction pathways in murine mammary adenocarcinoma cells . Positive_regulation PLAU PLD3 12458339 1021591 Src/ERK but not is *involved* in keratinocyte growth factor stimulated secretion of matrix metalloprotease-9 and [urokinase-type plasminogen activator] in SNU-16 human stomach cancer cell . Positive_regulation PLAU PLD3 9150275 430216 These results suggest for the first time that [uPA] production is *regulated* by and PKC signal transduction pathways in murine mammary adenocarcinoma cells . Positive_regulation PLAU PLD4 12458339 1021592 Src/ERK but not is *involved* in keratinocyte growth factor stimulated secretion of matrix metalloprotease-9 and [urokinase-type plasminogen activator] in SNU-16 human stomach cancer cell . Positive_regulation PLAU PLD4 9150275 430217 These results suggest for the first time that [uPA] production is *regulated* by and PKC signal transduction pathways in murine mammary adenocarcinoma cells . Positive_regulation PLAU PLD5 12458339 1021593 Src/ERK but not is *involved* in keratinocyte growth factor stimulated secretion of matrix metalloprotease-9 and [urokinase-type plasminogen activator] in SNU-16 human stomach cancer cell . Positive_regulation PLAU PLD5 9150275 430218 These results suggest for the first time that [uPA] production is *regulated* by and PKC signal transduction pathways in murine mammary adenocarcinoma cells . Positive_regulation PLAU PLD6 12458339 1021594 Src/ERK but not is *involved* in keratinocyte growth factor stimulated secretion of matrix metalloprotease-9 and [urokinase-type plasminogen activator] in SNU-16 human stomach cancer cell . Positive_regulation PLAU PLD6 9150275 430219 These results suggest for the first time that [uPA] production is *regulated* by and PKC signal transduction pathways in murine mammary adenocarcinoma cells . Positive_regulation PLAU PLG 10521785 653211 [Urokinase-type plasminogen activator] ( uPA ) *activation* of is an important mediator of cell migration in many cell types . Positive_regulation PLAU PLG 10524682 653858 Unexpectedly , incubation with IGF-1 inhibited this positive feedback of *dependent* [uPA] activity in OA osteoblasts , but not in normal osteoblasts , in a dose dependent manner . Positive_regulation PLAU PLG 10524682 653859 Hence , normal osteoblasts were relatively insensitive to IGF-1 , whereas the same treatment reduced both uPA levels and *dependent* [uPA] activity in OA osteoblasts while it increased basal uPA activity in OA osteoblasts . Positive_regulation PLAU PLG 10928473 719616 *Activation* of bound to surface associated MIP-2alpha by two-chain [urokinase-type plasminogen activator] ( tcu-PA ) was about 2.5-fold more efficient than in solution ( catalytic efficiency k ( cat ) K ( M ) of 0.1 microM ( -1 ) s ( -1 ) , as compared to 0.04 microM ( -1 ) s ( -1 ) . Positive_regulation PLAU PLG 10959704 726285 The assay is based on *activation* of by human [urokinase-type plasminogen activator] ( uPA ) and simultaneous measurement of generated plasmin with the specific plasmin substrate H-D-Val-Phe-Lys-4-nitroanilide ( S-2390 ) , using purified native rat plasminogen for calibration . Positive_regulation PLAU PLG 10974349 729298 C-I-H enhanced the *activation* of Glu- and by high molecular weight [urokinase-type plasminogen activator] ( HMW u-PA ) very effectively , but the activation by low molecular weight u-PA was hardly enhanced with C-I-H . Positive_regulation PLAU PLG 11027463 738932 The following activation mechanism for proteinase might occur : [uPA] coexpressed with MMP-9 *activated* plasminogen , and activated proMMP-3 , which was secreted depending upon inflammatory infiltration , and then MMP-3 activated proMMP-9 , resulting in colorectal cancer progression and metastasis . Positive_regulation PLAU PLG 11323016 807245 *Activation* of cell bound by two-chain [urokinase-type plasminogen activator] ( tcu-PA ) was not significantly different with SMC or fibroblasts from the gene-deficient mice ( 78 % to 140 % of wild-type ) . Positive_regulation PLAU PLG 11689350 876196 The membrane macromolecule that is responsible for plasminogen binding and for supporting *activation* of by [uPA] on the surfaces of these cell types remains to be determined . Positive_regulation PLAU PLG 11965442 953781 The components of the PPS include the [urokinase plasminogen activator (uPA)] , its cell surface receptor urokinase plasminogen activator receptor ( uPAR ) , and its naturally occurring *inhibitors* , activator inhibitors 1 and 2 ( PAI-1 and PAI-2 ) . Positive_regulation PLAU PLG 12138369 969227 In contrast , binding and *activation* of by single-chain [urokinase-type plasminogen activator] ( scu-PA ) at the surface of blood monocytes and alveolar macrophages were not different from those of control values . Positive_regulation PLAU PLG 12142372 969568 Paradoxically , high concentrations of activator inhibitor ( PAI-1 ) , an endogenous *inhibitor* of [uPA] , also correlate with poor prognosis in patients with breast cancer , including the subgroup with node negative disease . Positive_regulation PLAU PLG 12182908 977902 In addition , [sc-uPA] *activation* to two-chain uPA ( tc-uPA ) by and plasminogen activation to plasmin by tc-uPA were both found to be inhibited by ATF . Positive_regulation PLAU PLG 12182908 977905 Kinetic analysis showed that [sc-uPA] *activation* by competitively inhibited by ATF and CPB pretreated ATF (CPB-ATF) with an inhibitory constant ( K ( i ) ) of 3.8+/-0.31 and 12.4 +/- 1.8 microM , respectively . Positive_regulation PLAU PLG 12182908 977906 In contrast to sc-uPA induced Glu- or Lys-plasminogen activation , sc-uPA induced mini-plasminogen activation , [sc-uPA] *activation* by and mini-plasminogen activation by tc-uPA were not affected by ATF . Positive_regulation PLAU PLG 12182908 977909 These findings suggested that the inhibitory effects of ATF on [sc-uPA] *activation* by and Glu- or Lys-plasminogen activation by tc-uPA were related to the binding of ATF ( by its C-terminal Lys ( 135 ) and internal Lys/Arg residue ) with the kringle 1-4 of plasmin and plasminogen , respectively . Positive_regulation PLAU PLG 12431907 1054936 To address the hypothesis that the liver injury in transgenic mice results from the intracellular *activation* of by transgene derived [uPA] ( uPAT ) , we generated mice that overexpress uPAT and lack functional plasminogen ( uPAT-Plg ( - ) ) . Positive_regulation PLAU PLG 12543785 1050811 Besides degrading of matrix proteins , PMN-E has been shown to be able to cleave and inactivate plasminogen activator inhibitor-1 ( PAI-1 ) , the main *inhibitor* of [uPA] , and alpha2-antiplasmin , the natural inhibitor of , thus enabling an uncontrolled matrix degradation by the fibrinolytic enzymes . Positive_regulation PLAU PLG 12750156 1119614 Moreover , the *activation* of by [pro-uPA] is increased by soluble p97 . Positive_regulation PLAU PLG 12853975 1110179 In these tumors , the expression pattern of [uPA] and PAI-1 resembles that of human ductal breast cancer and is *required* for efficient metastasis . Positive_regulation PLAU PLG 12915673 1129967 To date , the factors capable of regulating the coordinate expression of the urokinase-type plasminogen activator ( [uPA] ) and its endogenous *inhibitor* , activator inhibitor ( PAI-1 ) , at the maternal-fetal interface remain poorly characterized . Positive_regulation PLAU PLG 14515195 1147044 Active plasmin is generated by proteolytic *activation* of the zymogen by [urokinase-type plasminogen activator] ( uPA ) and tissue-type plasminogen activator ( tPA ) . Positive_regulation PLAU PLG 1524563 197144 At the same time , [urokinase-type plasminogen activator] is stimulated in tissue constituent cells and activity *increases* locally . Positive_regulation PLAU PLG 15353482 1359037 *Activation* of by [urokinase plasminogen activator (uPA)] plays important roles in several physiologic and pathologic conditions . Positive_regulation PLAU PLG 15353482 1359040 In contrast , neither Glunor Lys-plasminogen inhibits the *activation* of by 2-chain [uPA] . Positive_regulation PLAU PLG 15574344 1355675 Active plasmin is generated by proteolytic *activation* of the zymogen by [urokinase-type plasminogen activator] ( uPA ) and tissue-type plasminogen activator ( tPA ) . Positive_regulation PLAU PLG 16391791 1505823 Furthermore , [uPA-treatment] significantly *induced* the expression of and uPAR in the conditioned medium of non dissociated ( PC-1 ) pancreatic cancer cells . Positive_regulation PLAU PLG 16554301 1562045 2 ) activation of plasminogen by [uPA] and subsequent *activation* of transforming growth factor-beta1 ( TGF-beta1 ) and matrix metalloproteinase (MMP)-2 and -9 by are critical pathways through which uPA expressing macrophages accumulate in the heart and cause fibrosis ; Positive_regulation PLAU PLG 16979249 1628098 We have recently demonstrated , that truncated human recombinant soluble melanotransferrin ( sMTf ) could stimulate the *activation* of by [urokinase plasminogen activator] and inhibit angiogenesis . Positive_regulation PLAU PLG 17709546 1783166 [Urokinase-type plasminogen activator] stimulation of monocyte matrix metalloproteinase-1 production is *mediated* by dependent signaling through annexin A2 and inhibited by inactive plasmin . Positive_regulation PLAU PLG 1827121 155290 Analysis of enzymatic activity indicates that under conditions where [syn-uPA] and std-uPA are completely *inhibited* by endothelial-type activator inhibitor ( PAI-1 ) , mut-uPA retains 90 % activity . Positive_regulation PLAU PLG 1828371 158637 This treatment exhaustively inactivated the Tc-uPA contaminant but did not affect Sc-uPA , as evidenced by the lack of significant incorporation of radiolabeled inhibitor in Sc-uPA and full *activation* of the inhibitor treated [Sc-uPA] by . Positive_regulation PLAU PLG 1829461 161324 Therefore , the cellular binding of Plg appears to be of critical importance for the efficient *activation* of by receptor bound [uPA] . Positive_regulation PLAU PLG 18799467 1986867 In enzyme activity assays in vitro , mU1 blocked uPA catalyzed plasminogen activation as well as mediated [pro-uPA] *activation* , whereas mU3 only was directed against the first of these reactions . Positive_regulation PLAU PLG 18808175 1981281 Up-regulation of uPA and uPAR in cancer appears to potentiate the malignant phenotype , either ( i ) directly by triggering mediated degradation or *activation* of [uPA] 's or plasmin 's proteolytic targets ( e.g. , extracellular matrix zymogen proteases or nascent growth factors ) or indirectly by simultaneously altering a range of downstream functions including signal transduction pathways ( Romer , J. ; Positive_regulation PLAU PLG 1948823 171271 We measured antigen levels of two kinds of plasminogen activators , tissue type plasminogen activator (t-PA) and [urokinase type plasminogen activator] ( UK ) , as well as their primary *inhibitor* , type-1 activator inhibitor ( PAI-1 ) in the tissue extracts of benign and malignant breast tumors . Positive_regulation PLAU PLG 19616049 2137401 Unlike constitutively active plasminogen activators , single chain [urokinase plasminogen activator] ( scuPA ) is *activated* by proteolysis or binding to its receptor , uPAR . Positive_regulation PLAU PLG 1969415 128684 The mechanism of the *activation* of by single-chain [urokinase-type plasminogen activator] ( single-chain u-PA , scu-PA ) was studied using rscu-PA-Glu158 , a recombinant plasmin-resistant mutant of human scu-PA obtained by site-specific mutagenesis of Lys158 to Glu , and rPlg-Ala740 , a recombinant human plasminogen in which the catalytic site is destroyed by mutagenesis of the active-site Ser740 to Ala. Conversion of 125I labeled single-chain plasminogen to two-chain plasmin was quantitated on reduced sodium dodecyl sulfate-gel electrophoresis combined with autoradiography and radioisotope counting of gels bands . Positive_regulation PLAU PLG 20180903 2307276 *Activation* of single-chain [urokinase-type plasminogen activator] by platelet associated : a mechanism for stimulation of fibrinolysis by platelets . Positive_regulation PLAU PLG 20537284 2271644 also *stimulated* [uPA] expression in CRS patient fibroblasts after 48 hours ( p < 0.04 ) . Positive_regulation PLAU PLG 20693403 2437274 This study shows that airway smooth muscle *activation* of by [uPA] is accelerated in a collagen-rich environment in which the inhibitory effect of TGF-ß is attenuated in association with greater uPA expression induced via ß1-integrin signaling . Positive_regulation PLAU PLG 2197510 138019 TPA treated K562 cells also synthesize and secrete platelet derived growth factor ( PDGF ) , transforming growth factor beta 1 ( TGF beta 1 ) , [urokinase-plasminogen activator (u-PA)] and its specific *inhibitor* , type 1 activator inhibitor ( PAI-1 ) . Positive_regulation PLAU PLG 21976662 2512844 DNA ( 0.1-5.0 µg/ml ) , but not RNA , potentiates the *activation* of Glu- and by tPA and [uPA] by 480- and 70-fold and 10.7- and 17-fold , respectively , via a template mechanism similar to that known for fibrin . Positive_regulation PLAU PLG 23341464 2753961 Moreover , upon *activation* of PepO bound by [urokinase-type plasminogen activator] , generated plasmin cleaved complement protein C3b thus assisting in complement control . Positive_regulation PLAU PLG 23835563 2839026 To investigate the prognostic value of urokinase-type plasminogen activator ( [uPA] ) and its *inhibitor* , type-1 activator inhibitor ( PAI-1 ) , in differentiated thyroid cancer . Positive_regulation PLAU PLG 2942403 60776 Selective use of these monoclonal antibodies demonstrated unequivocally that *mediates* the activation of the proenzyme form of [urokinase-type plasminogen activator] . Positive_regulation PLAU PLG 2943315 61918 Direct analyses of plasminogen activation by polyacrylamide gel electrophoresis demonstrate that heparin increases the *activation* of by both tPA and [uPA] . Positive_regulation PLAU PLG 2977134 103344 Single-chain [urokinase-type plasminogen activator] ( scu-PA ) , a potential therapeutic reagent for thrombosis , is *activated* in plasma by . Positive_regulation PLAU PLG 3023326 65681 These data show that secreted [pro-uPA] can find its way to the specific surface receptor without previous conversion to the two-chain form and that , once bound , can be *activated* by . Positive_regulation PLAU PLG 3609016 76718 *Activation* of by single-chain [urokinase-type plasminogen activator] ( sc-uPA ) , isolated from human urine , was studied in a purified system in the absence and presence of the cyanogen bromide fibrinogen fragment , FCB 2 , and compared to plasminogen activation by two-chain high-Mr urokinase . Positive_regulation PLAU PLG 3778931 65260 Comparative kinetic analysis of the *activation* of human by natural and recombinant single-chain [urokinase-type plasminogen activator] . Positive_regulation PLAU PLG 8063761 268790 It has been postulated that this may be due , in part , to an enhanced *mediated* feedback activation of [pro-uPA] . Positive_regulation PLAU PLG 8128448 242061 As reported in recent literature , heparin stimulated the *activation* of by high molecular weight ( HMW ) and low molecular weight ( LMW ) two-chain [urokinase-type plasminogen activator] ( u-PA ) and two-chain tissue-type plasminogen activator (t-PA) 10- to 17-fold . Positive_regulation PLAU PLG 8257443 238568 Suramin inhibited plasmin activation of [pro-uPA] by a non-competitive mechanism ( Ki approx. 2 micrograms/ml ) , which did not *involve* a direct effect on catalytic activity . Positive_regulation PLAU PLG 8444857 213709 [Pro-uPA] *activation* by was also accelerated , although to a lesser extent . Positive_regulation PLAU PLG 8662951 367696 Plasminogen activation catalyzed by the urokinase-type plasminogen activator ( uPA ) constitutes a reciprocal zymogen activation system , as can efficiently *activate* [pro-uPA] , the single-chain zymogenic form of the protease . Positive_regulation PLAU PLG 8662951 367697 In contrast to the increased efficiencies of activation and [pro-uPA] *activation* observed with cell-surface uPAR , soluble uPAR had an inhibitory effect on both of these individual reactions . Positive_regulation PLAU PLG 8778334 371435 Both the stroma and the epidermis may contribute to local spread of the tumour through production of [uPA] and consequent mediated *activation* of collagenases and metalloproteinases . Positive_regulation PLAU PLG 8804418 382166 This delay of the activation system was shown to include a partial inhibition of the *mediated* activation of [pro-uPA] as well as of the uPA mediated activation of plasminogen . Positive_regulation PLAU PLG 9141488 428410 Myosin binds both tPA and plasminogen , and enhances *activation* of by tPA but not by [urokinase-type plasminogen activator] ( uPA ) . Positive_regulation PLAU PLG 9151959 430893 The two zymogens , plasminogen and pro-urokinase plasminogen activator ( pro-uPA ) , constitute a system of reciprocal activation , since , generated by uPA catalysed plasminogen activation , can *activate* [pro-uPA] to uPA . Positive_regulation PLAU PLG 9521847 493836 They amplified plasminogen activation in culture supernatants up to 70-fold by stimulating ( i ) [pro-uPA] *activation* by and ( ii ) plasminogen activation by uPA . Positive_regulation PLAU PRDX2 17923479 1830352 Chromatin immunoprecipitation assays showed that the *induction* of [uPA] expression by was accompanied by a remarkable increase of acetylation of histones H3 and H4 , which are associated with the uPA promoter region in human cancer cells . Positive_regulation PLAU PRDX2 17923479 1830353 These results were further substantiated by the findings of a restriction enzyme accessibility assay and *stimulated* [uPA] promoter activity through the inhibition of HDAC activity . Positive_regulation PLAU PRKCG 12939403 1133247 This behavior correlated with increased production of [uPA] and MMPs-9/-2 *induced* by . Positive_regulation PLAU PRL 10457348 639294 Estradiol and insulin did not alter , whereas human chorionic gonadotropin and *increased* [uPA] activity . Positive_regulation PLAU PRL 9724020 529330 Increased production of PAI-1 induced by 16K *results* in the formation of inactive [PAI-1/uPA] complexes , consistent with the observed decrease in uPA activity . Positive_regulation PLAU PROK1 11820789 908831 Induction of [uPA] but not NF-IL3A by calcitonin is *dependent* on Erk1/2 phosphorylation in porcine renal cell line . Positive_regulation PLAU PTGS2 21592330 2441483 *dependent* and independent activation of [CK2a-Akt/uPA] signal is mainly involved in urothelial carcinoma cell survival , moreover , not only COX2 but also CK2a could be direct targets of COX2 inhibitors . Positive_regulation PLAU PTH 1796756 176339 However , also *enhanced* the release of [uPA] ( both the 48 kD and the 29 kD forms ) from the bones into the media . Positive_regulation PLAU PTH 1796756 176341 Although inhibiting bone resorption , calcitonin had no effect on the PTH induced accumulation of PA in bone or on the release of tPA , but it prevented the *induced* accumulation of 29 kD [uPA] in the culture fluids . Positive_regulation PLAU PTPN11 19133257 2042517 Elucidating the underlying mechanisms , we found that [uPA] *induced* recruitment to lipid rafts . Positive_regulation PLAU PXDNL 14871936 1208381 Overexpression of *suppressed* some ret1 mutant phenotypes , namely , Ca2+ dependence and enhanced [uPA] secretion . Positive_regulation PLAU RBL2 12546716 1051151 Rb2 greatly or moderately increased the amount of urokinase-type PA (uPA) or its inhibitor ( PAI-1 ) , present in the culture medium , whereas saponin did not influence mRNA levels of uPA , its surface receptor , and PAI-1 , suggesting that may *stimulate* the secretion of [uPA] without enhancing its gene expression . Positive_regulation PLAU RBL2 12546716 1051152 may *stimulate* the secretion of [uPA] without enhancing the gene expression of uPA , uPA receptor (uPAR) , and PAI-1 . Positive_regulation PLAU RELA 10467400 640768 We report that the [urokinase-type plasminogen activator] ( uPA ) , one of the critical proteases involved in tumor invasion and metastasis , is overexpressed in pancreatic tumor cells and its overexpression is *induced* by constitutive activity . Positive_regulation PLAU RELA 10467400 640770 The uPA promoter contains an NF-kappaB binding site that directly mediates the *induction* of [uPA] expression by . Positive_regulation PLAU RELA 11689575 903859 The urokinase-type plasminogen activator ( uPA ) promoter contains an NF-kappaB binding site , and [uPA] expression in MDA-MB-231 cells is *induced* by the constitutively active . Positive_regulation PLAU RELA 11689575 903869 Furthermore , inhibition of NF-kappaB markedly attenuated endogenous migration , and inhibition of PI 3-kinase and *reduced* secretion of [uPA] . Positive_regulation PLAU RELA 12477728 1056099 To our knowledge , this is the first report that Syk suppresses the cell motility and *inhibits* the PI 3'-kinase activity and [uPA] secretion by blocking activity through tyrosine phosphorylation of I kappa B alpha . Positive_regulation PLAU RELA 14534291 1174985 Luciferase reporter gene assay indicated that Lck induces *dependent* [urokinase type plasminogen activator] ( uPA ) promoter activity in presence of H/R . Positive_regulation PLAU RELA 16109653 1445277 To evaluate the *role* of transcription factor in [uPA] and uPAR gene transcription with H. pylori stimulation , the effect of NF-kappaB inhibitor MG132 on H. pylori induced uPA and uPAR mRNA expression was examined . Positive_regulation PLAU RELA 16340751 1504032 Subsequently , the EGF induced MMP-9 and [uPA] expression and MMP-9 activity , as well as cell invasiveness , were also *inhibited* by these inhibitors . Positive_regulation PLAU RELA 16691505 1560383 Taken together , NIK acts as crucial regulator in OPN induced MAPK/IKK mediated *dependent* [uPA] secretion and MMP-9 activation thereby controlling melanoma cell motility and chemoinvasion . Positive_regulation PLAU RELA 17510309 1745188 SN50 , a specific inhibitor of , which could inhibit in vitro invasive and migratory abilities of gastric cancer cells , *reduced* expression of [uPA] and MMP9 proteins and increased expression of TIMP1 protein . Positive_regulation PLAU RELA 17571974 1763286 Expression of [uPA] is *regulated* in part by the oxidant-sensitive transcription factor , , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Positive_regulation PLAU RELA 18478929 1840488 Subsequently , the EGF induced [uPA] expression and invasiveness were also *inhibited* by inhibitor . Positive_regulation PLAU RELA 18478929 1840490 Our findings indicated that *mediated* up-regulation of [uPA] expression is responsible for EGF induced invasiveness in pancreatic cancer cells , and implicate that such anti-NF-kappaB therapy with NF-kappaB inhibitors may contribute to the reduction of invasiveness of pancreatic cancer . Positive_regulation PLAU RELA 1905804 161660 Our results suggest that maximal transcriptional activation of the [uPA] gene by PMA , IL-1 and TNF alpha *requires* the induction of activity and the decay of a short lived repressor protein , possibly IkB . Positive_regulation PLAU RELA 19165610 2038430 The BRMS1 metastasis suppressor was recently shown to negatively regulate NF-kappaB signaling and down regulate *dependent* [uPA] expression . Positive_regulation PLAU RELA 19303700 2064333 Inhibition of activity significantly reduced proliferation and invasion of Hep3B cells as well as *down-regulated* the expression of invasion related molecules including matrix metalloproteinase (MMP)-2 , MMP-9 , membrane type-1 MMP (MT1-MMP) , [urokinase plasminogen activator (uPA)] and vascular endothelial growth factor ( VEGF ) . Positive_regulation PLAU RELA 20204677 2272548 Our results shows that TGF-beta1 stimulation of [uPA] and MMP-9 expression *involve* NOXs dependent ROS and , activation , demonstrated by using DPI , NOXs inhibitor , ROS scavenger N-acetylcysteine and SN50 , an NFkb inhibitor . Positive_regulation PLAU RELA 20204677 2272560 Thus , *acts* as the crucial signal in TGF-beta1 induced [uPA] and MMP-9 expression thereby mediating the enhancement of cellular malignity by TGF-beta1 . Positive_regulation PLAU RELA 20502321 2301210 *dependent* regulation of [urokinase plasminogen activator] by proanthocyanidin-rich grape seed extract : effect on invasion by prostate cancer cells . Positive_regulation PLAU RELA 20502321 2301214 Additional studies showed that GSE inhibited DNA binding activity of the transcription factor nuclear factor kappa B (NFkappaB) , which in turn decreased *dependent* [uPA] transcription . Positive_regulation PLAU RELA 8804426 382182 Using the protein synthesis inhibitor cycloheximide and the antioxidant PDTC , that have an opposite effect on NF-kappa B and AP-1 activation , we showed that [uPA] mRNA induction by TNF-alpha and PMA in the A549 cell line is mainly *due* to activation . Positive_regulation PLAU RELA 9914486 586959 In a previous study we observed that suppression of dramatically *reduced* endogenous [uPA] synthesis in the human ovarian cancer cell line OV-MZ-6 . Positive_regulation PLAU RENBP 8526923 336612 The [uPA] *induction* by was effectively suppressed by the antibody against granulocyte-macrophage colony stimulating factor ( GM-CSF ) . Positive_regulation PLAU RENBP 8526923 336613 These data provide evidence that *stimulates* the [uPA] activity via GM-CSF through MSR in RAW cells . Positive_regulation PLAU RENBP 8526923 336614 These findings , taken together with a recent demonstration of endocytic uptake of AGE-proteins by MSR in vitro and the presence of AGE-proteins in atherosclerotic lesions , strongly suggest that the [uPA] *induction* by via MSR plays an important role in human atherogenesis . Positive_regulation PLAU RPSA 20491781 2288865 Western blot analysis showed that <67LR> *increased* the expression of [urokinase-type plasminogen activator] ( uPA ) and matrix metalloproteinase (MMP)-9 , and decreased tissue inhibitor of matrix metalloproteinase ( TIMP ) -1 protein . Positive_regulation PLAU SEMA5A 23661031 2819253 Blocking effects of PI3K/Akt using pharmacologic inhibitors , dominant negative mutants abolished the ability of to *induce* [uPA] expression and cell invasion and migration . Positive_regulation PLAU SERPINB2 12813409 1103135 , amiloride , *blocked* [uPA] activity in retinal extracts . Positive_regulation PLAU SERPINB2 8635500 362050 When comparing HaCaT and HaRas cells , we found that the cell lines secreted comparable levels of uPA antigen , whereas the levels of [uPA] activity were low in the *presence* of , indicating that PAI-2 serves to regulate uPA activity . Positive_regulation PLAU SERPINB5 11751384 889880 expression *led* to a significantly reduced level of cell surface bound [uPA] and uPA receptor proteins without altering the steady-state levels of the respective mRNAs . Positive_regulation PLAU SERPINB5 15846059 1439530 *regulates* hypoxia mediated stimulation of [uPA/uPAR] complex in invasive breast cancer cells . Positive_regulation PLAU SERPINB5 16618739 1551072 The effects on surface associated uPA and uPAR *required* the interaction between [uPA] and uPAR . Positive_regulation PLAU SERPINB5 21810423 2505347 This study suggests that extracellular *increased* pro and active [uPA] and tPA released by corneal fibroblasts and myofibroblasts on the short time scale of 1-4 h , but by 24 h there was no increase over the levels produced without maspin . Positive_regulation PLAU SERPINE1 12142372 969567 Paradoxically , high concentrations of plasminogen activator *inhibitor* ( ) , an endogenous inhibitor of [uPA] , also correlate with poor prognosis in patients with breast cancer , including the subgroup with node negative disease . Positive_regulation PLAU SERPINE1 12915673 1129966 To date , the factors capable of regulating the coordinate expression of the [urokinase-type plasminogen activator] ( uPA ) and its endogenous *inhibitor* , plasminogen activator inhibitor ( ) , at the maternal-fetal interface remain poorly characterized . Positive_regulation PLAU SERPINE1 15995956 1430027 The decreased active [uPA] levels in infected organs might be *due* to the dramatically increased production during S. aureus infection . Positive_regulation PLAU SERPINE1 16077925 1442402 ( PAI-1 ) *regulates* the proteolytic activity of [urokinase-type plasminogen activator] ( uPA ) and there is increasing evidence for a PAI-1 role in regulating cell migration/invasion by other mechanisms like vitronectin (VN) binding and lipoprotein-receptor related protein ( LRP ) binding . Positive_regulation PLAU SERPINE1 1827121 155289 Analysis of enzymatic activity indicates that under conditions where [syn-uPA] and std-uPA are completely *inhibited* by endothelial-type plasminogen activator inhibitor ( ) , mut-uPA retains 90 % activity . Positive_regulation PLAU SERPINE1 1948823 171270 We measured antigen levels of two kinds of plasminogen activators , tissue type plasminogen activator (t-PA) and [urokinase type plasminogen activator] ( UK ) , as well as their primary *inhibitor* , type-1 plasminogen activator inhibitor ( ) in the tissue extracts of benign and malignant breast tumors . Positive_regulation PLAU SERPINE1 19514465 2092711 Except its role in plasminogen cascade , PAI-1 has an affinity to vitronectin and [uPA/uPAR] what *involves* in cell 's motility . Positive_regulation PLAU SERPINE1 21316840 2398832 Herein we show that PAI-2 is capable of inhibiting [uPA] in the *presence* of , particularly on adherent cells in the presence of vitronectin . Positive_regulation PLAU SERPINE1 2197510 138018 TPA treated K562 cells also synthesize and secrete platelet derived growth factor ( PDGF ) , transforming growth factor beta 1 ( TGF beta 1 ) , [urokinase-plasminogen activator (u-PA)] and its specific *inhibitor* , type 1 plasminogen activator inhibitor ( ) . Positive_regulation PLAU SERPINE1 23835563 2839025 To investigate the prognostic value of urokinase-type plasminogen activator ( [uPA] ) and its *inhibitor* , type-1 plasminogen activator inhibitor ( ) , in differentiated thyroid cancer . Positive_regulation PLAU SETD2 17357815 1720341 DFO treatment resulted in *mediated* induction of [urokinase plasminogen activator] receptor and matrix metalloproteinase 2 . Positive_regulation PLAU SETD2 20807755 2324628 At 1 % O ( 2 ) , vascular endothelial growth factor was regulated by both and HIF-2a , but glucose transporter 1 , carbonic anhydrase 9 , and [urokinase-type plasminogen activator] receptor were *regulated* by HIF-1a rather than by HIF-2a . Positive_regulation PLAU SFTPC 15854129 1399954 Subsequently , we examined whether SPC affected the production of urokinase-type plasminogen activator ( uPA ) , an important regulator of angiogenesis , and found that *stimulated* the expression of [uPA] at both the transcriptional and translational levels . Positive_regulation PLAU SHC1 17222183 1689171 *Induction* of [uPA] gene expression by the blockage of E-cadherin via Src- and dependent Erk signaling . Positive_regulation PLAU SMAD3 21798735 2605053 is *essential* for transforming growth factor-ß1 induced [urokinase type plasminogen activator] expression and migration in transformed keratinocytes . Positive_regulation PLAU SMAD3 21798735 2605055 In the present study , we analysed the *role* of TGF-ß1 induced activation in the [urokinase type plasminogen activator] ( uPA ) production , as well as in cell migration and E-cadherin downregulation in transformed PDV keratinocyte cell line . Positive_regulation PLAU SMC2 14718842 1197629 [sc-uPA] *induces* proliferation and migration , which are domain dependent and mediated in part by Galphai linked , ERK dependent processes , while only the mitogenic response is protease dependent . Positive_regulation PLAU SMC3 14718842 1197633 [sc-uPA] *induces* proliferation and migration , which are domain dependent and mediated in part by Galphai linked , ERK dependent processes , while only the mitogenic response is protease dependent . Positive_regulation PLAU SMC4 14718842 1197630 [sc-uPA] *induces* proliferation and migration , which are domain dependent and mediated in part by Galphai linked , ERK dependent processes , while only the mitogenic response is protease dependent . Positive_regulation PLAU SMC5 14718842 1197631 [sc-uPA] *induces* proliferation and migration , which are domain dependent and mediated in part by Galphai linked , ERK dependent processes , while only the mitogenic response is protease dependent . Positive_regulation PLAU SMC6 14718842 1197632 [sc-uPA] *induces* proliferation and migration , which are domain dependent and mediated in part by Galphai linked , ERK dependent processes , while only the mitogenic response is protease dependent . Positive_regulation PLAU SP1 10361124 619759 Finally , and RAR/RXR synergistically *enhanced* the transactivation activity of the [uPA] promoter . Positive_regulation PLAU SP1 21076612 2345136 Accordingly , GATA6 physically associated with Sp1 and siRNA knockdown of Sp1 decreased GATA6 activation of the uPA promoter activity suggesting that recruits GATA6 to the uPA promoter and *mediates* GATA6 induced activation of the [uPA] promoter activity . Positive_regulation PLAU SP1 21567400 2562274 Inhibition of and AP-1 activation *blocked* the SDF-1 induced expression and activity of the [uPA] promoter . Positive_regulation PLAU SPARC 18813349 1970012 Overexpression of in ovarian cancer cells significantly *attenuated* macrophage- and mesothelial cell induced production and activity of interleukin-6 , prostanoids ( prostaglandins E2 and 8-isoprostanes ) as well as matrix metalloproteinases and [urokinase plasminogen activator] . Positive_regulation PLAU SPHK1 22684547 2705934 Moreover , was *required* for the production of MMP-2/9 and [uPA] in tumor cells , which was suppressed by ERK1/2 inhibitor U0126 , but enhanced by the p38 MAPK inhibitor SB203580 . Positive_regulation PLAU SPP1 11804183 892574 We have recently shown that either exogenous or endogenous , transfected *induces* both [uPA] expression and increased invasiveness of 21 PT ( non-tumorigenic ) and 21 NT ( tumorigenic ) human mammary epithelial cells . Positive_regulation PLAU SPP1 12771144 1113283 *stimulates* cell motility and nuclear factor kappaB mediated secretion of [urokinase type plasminogen activator] through phosphatidylinositol 3-kinase/Akt signaling pathways in breast cancer cells . Positive_regulation PLAU SPP1 12771144 1113285 However , the molecular mechanism by which upstream kinases regulate the *induced* NFkappaB activation and [urokinase type plasminogen activator] ( uPA ) secretion in human breast cancer cells is not well defined . Positive_regulation PLAU SPP1 12771144 1113346 also *enhances* [uPA] secretion , cell motility , and extracellular matrix invasion . Positive_regulation PLAU SPP1 12771144 1113347 Furthermore , cells transfected with Deltap85 or the super-repressor form of IkappaBalpha suppressed the *induced* [uPA] secretion and cell motility , whereas cells transfected with p110CAAX enhanced these effects . Positive_regulation PLAU SPP1 12771144 1113348 Pretreatment of cells with PI 3-kinase inhibitors or NFkappaB inhibitory peptide ( SN-50 ) reduced the *induced* [uPA] secretion , cell motility , and invasion . Positive_regulation PLAU SPP1 12771144 1113359 To our knowledge , this is first report that OPN induces NFkappaB activity and uPA secretion by activating PI 3'-kinase/Akt/IKK mediated signaling pathways and further demonstrates a functional molecular link between *induced* PI 3'-kinase dependent Akt phosphorylation and NFkappaB mediated [uPA] secretion , and all of these ultimately control the motility of breast cancer cells . Positive_regulation PLAU SPP1 14704150 1219035 *induces* AP-1 mediated secretion of [urokinase-type plasminogen activator] through c-Src dependent epidermal growth factor receptor transactivation in breast cancer cells . Positive_regulation PLAU SPP1 14704150 1219067 To our knowledge , this is the first report that *induces* alpha(v)beta(3) integrin mediated AP-1 activity and [uPA] secretion by activating c-Src/EGFR/ERK signaling pathways and further demonstrates a functional molecular link between OPN induced integrin/c-Src dependent EGFR phosphorylation and ERK/AP-1 mediated uPA secretion , and all of these ultimately control the motility of breast cancer cells . Positive_regulation PLAU SPP1 15757900 1403540 also *enhanced* JNK1 dependent/independent AP-1 mediated [urokinase type plasminogen activator] ( uPA ) secretion , uPA dependent promatrix metalloproteinase-9 ( MMP-9 ) activation , cell motility , and invasion . Positive_regulation PLAU SPP1 16012053 1431593 However , the molecular mechanism by which upstream kinases regulate the *induced* NFkappaB activation and [uPA] secretion in human breast cancer cells is not well defined . Positive_regulation PLAU SPP1 16012053 1431617 also *enhances* [uPA] secretion , cell motility and ECM-invasion . Positive_regulation PLAU SPP1 16012053 1431618 Furthermore , cells transfected with Deltap85 or super-repressor form of IkappaBalpha suppressed the *induced* [uPA] secretion and cell motility . Positive_regulation PLAU SPP1 16012053 1431619 Pretreatment of cells with PI 3'-kinase inhibitors or NFkappaB inhibitory peptide ( SN50 ) reduced the *induced* [uPA] secretion , cell motility and ECM-invasion . Positive_regulation PLAU SPP1 16012053 1431627 Taken together , *induces* NFkappaB activity and [uPA] secretion by activating PI 3'-kinase/Akt/IKK mediated signaling pathways and further demonstrates a functional molecular link between OPN induced PI 3'-kinase dependent Akt phosphorylation and NFkappaB mediated uPA secretion , and all of these ultimately control the motility and invasiveness of breast cancer cells . Positive_regulation PLAU SPP1 16691505 1560357 Furthermore , *enhances* NIK regulated [urokinase-type plasminogen activator] ( uPA ) secretion , uPA dependent pro-MMP-9 activation , and cell motility . Positive_regulation PLAU SPP1 16691505 1560381 Taken together , NIK acts as crucial regulator in *induced* MAPK/IKK mediated NF-kappaB dependent [uPA] secretion and MMP-9 activation thereby controlling melanoma cell motility and chemoinvasion . Positive_regulation PLAU SPP1 17244457 1690748 might *enhance* the expression of MMP-2 and [uPA] to promote malignant phenotypes of SMMC-7721 cells . Positive_regulation PLAU SPP1 19885563 2161041 Consistently , OPN isoforms differentially activated migration associated signaling pathways such that OPN-a and -b increased the expression of [urokinase type plasminogen activator] and the phosphorylation of p42/p44 MAP kinase , but these pathways were not *activated* by . Positive_regulation PLAU SPP1 21104439 2437407 Together , these findings indicate that enhanced HCC cells invasion through interaction with its receptor CD44v6 and *increased* MMP-2 and [uPA] expressions , providing at least one mechanism for OPN mediated HCC progression and metastasis . Positive_regulation PLAU SPP1 21174062 2378755 Specific suppression of also *inhibited* matrix metalloproteinase 2 (MMP-2) and [urokinase-type plasminogen activator] ( uPA ) expression in HCCLM6 cells . Positive_regulation PLAU SPRED2 19908229 2247804 In the present work , we analyzed the *role* of in the [urokinase-type plasminogen activator] ( uPA ) stimulation , EMT and cell migration by TGF-beta1 . Positive_regulation PLAU SRC 12458339 1021590 but not phospholipase D is *involved* in keratinocyte growth factor stimulated secretion of matrix metalloprotease-9 and [urokinase-type plasminogen activator] in SNU-16 human stomach cancer cell . Positive_regulation PLAU SRC 12458339 1021609 However , only inhibition of and ERK could *block* KGF stimulated secretion of [uPA] and MMP-9 . Positive_regulation PLAU SRC 14704150 1219068 To our knowledge , this is the first report that OPN induces alpha(v)beta(3) integrin mediated AP-1 activity and uPA secretion by activating c-Src/EGFR/ERK signaling pathways and further demonstrates a functional molecular link between OPN induced *dependent* EGFR phosphorylation and ERK/AP-1 mediated [uPA] secretion , and all of these ultimately control the motility of breast cancer cells . Positive_regulation PLAU SRC 17611702 1768694 Further , tyrosine phosphorylation and functional were *required* for optimal [uPA] secretion . Positive_regulation PLAU ST14 10962009 744774 *Activation* of hepatocyte growth factor and [urokinase/plasminogen activator] by , an epithelial membrane serine protease . Positive_regulation PLAU ST14 10962009 744776 In addition , we noted that can *activate* [urokinase plasminogen activator] but has no affect on plasminogen . Positive_regulation PLAU ST14 14747469 1226283 , a membrane bound serine protease , was shown to *activate* [uPA] in a uPA receptor-free , solution based study . Positive_regulation PLAU ST14 14747469 1226286 Our data identify a novel *role* for for activation of receptor bound [uPA] . Positive_regulation PLAU ST14 16794252 1625118 Kinetic analysis demonstrated that is a relatively poor *activator* of [pro-uPA] in solution , approximately 100-fold less efficient than plasmin ( k ( cat ) /K ( m ) 1.16 x 10 ( 5 ) M(-1)s(-1) cf 1.21 x 10 ( 7 ) M(-1)s(-1) ) . Positive_regulation PLAU ST14 16794252 1625119 However , down-regulation of expression in THP-1 cells by siRNA *reduced* the activation of cell associated [pro-uPA] and the subsequent rapid initiation of plasminogen activation by 76 % to 93 % . Positive_regulation PLAU ST14 17511657 1745568 Using siRNA ( small interfering RNA ) , we have demonstrated that specifically *activates* uPAR associated [pro-uPA] . Positive_regulation PLAU STAT3 16751220 1605263 uPA induced activation does not *require* [uPA] catalytic activity , as the uPA amino-terminal fragment alone was as potent as active two-chain uPA ( tcuPA ) in causing this effect . Positive_regulation PLAU STAT3 16751220 1605265 Single-chain [uPA] likewise *induced* tyrosine phosphorylation of to a similar extent as intact tcuPA . Positive_regulation PLAU STX2 17935821 1819794 In vitro , *induced* matrix metalloproteinase (MMP) 9 , MMP 3 and [urokinase type plasminogen activator] ( uPA ) in hepatocytes . Positive_regulation PLAU TAT 11749069 898123 *stimulated* MEC growth and migration , but not [uPA] production , suggesting that Tat can not activate a complete angiogenic program in these cells , unless FGF-2 is present . Positive_regulation PLAU TAT 14982725 1214434 In addition , both and methamphetamine *stimulated* the release of the MMP activator [uPA] , and in a manner that was sensitive to inhibition with pertussis toxin . Positive_regulation PLAU TCF12 17571974 1763274 Expression of [uPA] is *regulated* in part by the oxidant-sensitive , NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Positive_regulation PLAU TCF15 17571974 1763275 Expression of [uPA] is *regulated* in part by the oxidant-sensitive , NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Positive_regulation PLAU TCF19 17571974 1763276 Expression of [uPA] is *regulated* in part by the oxidant-sensitive , NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Positive_regulation PLAU TCF20 17571974 1763277 Expression of [uPA] is *regulated* in part by the oxidant-sensitive , NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Positive_regulation PLAU TCF21 17571974 1763278 Expression of [uPA] is *regulated* in part by the oxidant-sensitive , NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Positive_regulation PLAU TCF23 17571974 1763282 Expression of [uPA] is *regulated* in part by the oxidant-sensitive , NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Positive_regulation PLAU TCF24 17571974 1763284 Expression of [uPA] is *regulated* in part by the oxidant-sensitive , NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Positive_regulation PLAU TCF25 17571974 1763283 Expression of [uPA] is *regulated* in part by the oxidant-sensitive , NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Positive_regulation PLAU TCF3 17571974 1763279 Expression of [uPA] is *regulated* in part by the oxidant-sensitive , NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Positive_regulation PLAU TCF4 17571974 1763280 Expression of [uPA] is *regulated* in part by the oxidant-sensitive , NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Positive_regulation PLAU TCF7 17571974 1763281 Expression of [uPA] is *regulated* in part by the oxidant-sensitive , NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Positive_regulation PLAU TGFB1 10482694 643846 Neither TSP-1 nor *had* an effect on [uPA] production . Positive_regulation PLAU TGFB1 10652434 663185 *induces* [uPA] and PAI-1 secretion and promotes binding of uPA at the external plasma membrane with increased membrane associated plasmin activity . Positive_regulation PLAU TGFB1 10873638 708452 PD098059 , an inhibitor of mitogen activated protein kinase (MAPK) kinase ( MEK ) , decreased *induced* [uPA] mRNA expression , secreted activity in a dose dependent manner , and abrogated TGF-beta(1) stimulated cell motility and invasiveness . Positive_regulation PLAU TGFB1 12074587 956808 Since anti-invasive effects of TGF-beta in the normal EVT cells were shown to be mediated in part by plasminogen activator inhibitor-1 ( PAI-1 ) and urokinase-type plasminogen activator ( uPA ) , we compared the expression of PAI-1 and [uPA] in the normal EVT , JAR , and JAR-smad3/c cells in the *presence* or absence of . Positive_regulation PLAU TGFB1 12806374 1101684 In PC-3 cells , and bFGF *increased* [urokinase plasminogen activator] secretion . Positive_regulation PLAU TGFB1 12841684 1108339 *increased* the production of [uPA] in PC3 and DU145 cells . Positive_regulation PLAU TGFB1 14676209 1211148 5 ) up-regulation of uPA mRNA in response to TGF-beta1 was almost totally blocked by PP2 and PD98059 and partially ( approximately 55 % ) by LY294002 ; 6 ) *induced* [uPA] mRNA up-regulation was inhibited by treatment with AS ODNs to c-Src or PI3K by 90 or 60 % , respectively , compared with control ODN treatment ; Positive_regulation PLAU TGFB1 14676209 1211149 and 7 ) blockade of the release of the transcription factor NF-kappaB by pyrrolidinedithiocarbamate reduced the *induced* activation of the [uPA] gene by approximately 65 % . Positive_regulation PLAU TGFB1 14676209 1211150 Taken together , these data support a role for TGF-beta1 activation of two distinct pathways ( Src-MAPK-PI3K-NF-kappaB dependent and Src-MAPK-AP-1 dependent ) for *dependent* [uPA] up-regulation and promotion of invasion . Positive_regulation PLAU TGFB1 15452360 1354473 The aim of this study was to determine whether ( TGF-beta1 ) *induces* the synthesis , release and gene expression of [urokinase-type plasminogen activator] ( uPA ) in hepatic stellate cells . Positive_regulation PLAU TGFB1 15452360 1354474 increased to 2-fold uPA activity in lysates from quiescent cells , and to 3.5-fold in activated cells , and *induced* [uPA] gene expression to the same extent in both activated and non activated cells . Positive_regulation PLAU TGFB1 15452360 1354475 These results show that the activity and gene expression of [uPA] are *regulated* by both acetaldehyde and and that the proteolytic activity in the extracellular space is reduced by the influence of TGF-beta1 . Positive_regulation PLAU TGFB1 16002410 1452870 To further elucidate the mechanism of the KTI dependent suppressive effect of *induced* [uPA] expression and invasion , we investigated which signaling pathway transduced by KTI is responsible for this inhibitory effect . Positive_regulation PLAU TGFB1 16554301 1562042 2 ) activation of plasminogen by [uPA] and subsequent *activation* of ( TGF-beta1 ) and matrix metalloproteinase (MMP)-2 and -9 by plasmin are critical pathways through which uPA expressing macrophages accumulate in the heart and cause fibrosis ; Positive_regulation PLAU TGFB1 17187779 1695318 Further , ILK-H reduced the basal and *stimulated* secretion of [uPA] , and increased the secretion of its inhibitor ( PAI-1 ) . Positive_regulation PLAU TGFB1 17625304 1770151 We previously reported that *up-regulated* vascular endothelial growth factor ( VEGF ) production , and the protease production of both MMP-2 and [urokinase-type plasminogen activator] in the highly metastatic pancreatic cancer cell lines SW1990 and CAPAN-2 . Positive_regulation PLAU TGFB1 18182987 1863070 These findings suggest that the microenvironment of SV enhances the progression of prostate cancer through a stimulated invasive potential , and that enhanced [uPA] production in prostate cancer cells *induced* by could therefore be one of the most important mechanisms involved in the progression of prostate cancer after SV invasion . Positive_regulation PLAU TGFB1 1908092 164319 *stimulates* [urokinase-type plasminogen activator] and DNA synthesis , but not prostaglandin E2 production , in human synovial fibroblasts . Positive_regulation PLAU TGFB1 19908229 2247800 Spred2 inhibits *induced* [urokinase type plasminogen activator] expression , cell motility and epithelial mesenchymal transition . Positive_regulation PLAU TGFB1 20204677 2272558 Thus , ROS-NFkappaB acts as the crucial signal in *induced* [uPA] and MMP-9 expression thereby mediating the enhancement of cellular malignity by TGF-beta1 . Positive_regulation PLAU TGFB1 7622580 315898 *induction* of [uPA] expression by THP-1 cells was differentiation dependent . Positive_regulation PLAU TGFB1 7684044 216604 The protein kinase C inhibitor H7 markedly reduced the ability of to *stimulate* expression of [uPA] activity . Positive_regulation PLAU TGFB1 8679225 372506 Phorbol myristate acetate , lipopolysaccharide , ( TGF-beta ) , and tumor necrosis factor-alpha (TNF-alpha) *increased* [uPA] binding and plasminogen activation at the cell surface , with a greater maximal effect on fibrotic than on normal fibroblasts . Positive_regulation PLAU TGFB1 9472634 486281 In MDA-MB-231 , had no effect on cell proliferation but *increased* [uPA] activity and PAI-1 antigen level ; Positive_regulation PLAU TGFB2 1908092 164320 *stimulates* [urokinase-type plasminogen activator] and DNA synthesis , but not prostaglandin E2 production , in human synovial fibroblasts . Positive_regulation PLAU TGFB2 8679225 372507 Phorbol myristate acetate , lipopolysaccharide , ( TGF-beta ) , and tumor necrosis factor-alpha (TNF-alpha) *increased* [uPA] binding and plasminogen activation at the cell surface , with a greater maximal effect on fibrotic than on normal fibroblasts . Positive_regulation PLAU TGFB3 1908092 164321 *stimulates* [urokinase-type plasminogen activator] and DNA synthesis , but not prostaglandin E2 production , in human synovial fibroblasts . Positive_regulation PLAU TGFB3 8679225 372508 Phorbol myristate acetate , lipopolysaccharide , ( TGF-beta ) , and tumor necrosis factor-alpha (TNF-alpha) *increased* [uPA] binding and plasminogen activation at the cell surface , with a greater maximal effect on fibrotic than on normal fibroblasts . Positive_regulation PLAU THBS1 10482694 643847 Neither nor TGF-beta1 *had* an effect on [uPA] production . Positive_regulation PLAU THBS1 10917542 716779 Tumour cell *induced* a 2-7 fold increase in [urokinase plasminogen activator] receptor and cell associated urokinase plasminogen activator expression and a 50-65 % increase in cell associated urokinase plasminogen activator and plasmin activities . Positive_regulation PLAU THBS1 15172186 1253944 *up-regulated* uPAR and [uPA] expression 3- and 4-fold , respectively . Positive_regulation PLAU TIMP2 24418973 2942437 We determined the level of the ECM proteases urokinase-like plasminogen activator ( [uPA] ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous MMP *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and in the conditioned media . Positive_regulation PLAU TMPRSS4 23978400 2888031 *upregulates* [uPA] gene expression through JNK signaling activation to induce cancer cell invasion . Positive_regulation PLAU TMPRSS4 23978400 2888033 Here , we demonstrated that induced the transcription of the urokinase-type plasminogen activator ( uPA ) gene through activating the transcription factors Sp1 , Sp3 , and AP-1 in mainly a JNK dependent manner and that the induction of [uPA] was *required* for TMPRSS4 mediated cancer cell invasion and signaling events . Positive_regulation PLAU TMPRSS4 23978400 2888034 In addition , the uPA receptor was involved in *induced* signaling activation and subsequent [uPA] expression probably through its association with TMPRSS4 on the cell surface . Positive_regulation PLAU TMPRSS4 23978400 2888035 the *upregulation* of [uPA] by contributes to invasion and may represent a novel mechanism for the control of invasion . Positive_regulation PLAU TMPRSS4 24434139 2927052 We also demonstrated that *upregulates* [urokinase-type plasminogen activator] ( uPA ) gene expression to induce cancer cell invasion . Positive_regulation PLAU TMPRSS6 12149247 991910 could also *activate* single-chain [urokinase plasminogen activator] , albeit with low efficiency . Positive_regulation PLAU TNF 11814314 892825 We have examined expression of the components of the plasminogen activation system in human astrocytoma U373-MG cells and found that interleukin 1beta (IL-1beta) , tumour necrosis factor alpha ) , interferon gamma (INF-gamma) and epidermal growth factor (EGF) specifically *regulate* the expression of tissue-type plasminogen activator (t-PA) , [urokinase-type plasminogen activator] ( u-PA ) , plasminogen activator inhibitor type 1 ( PAI-1 ) and protease nexin-1 (PN-1) . Positive_regulation PLAU TNF 12180971 977416 Our laboratory showed that bikunin , a Kunitz-type protease inhibitor , suppresses 4beta-phorbol 12-myristate 13-acetate ( PMA ) - or *induced* [urokinase-type plasminogen activator] ( uPA ) expression in different cell types . Positive_regulation PLAU TNF 1311745 179049 Immunoreactive [uPA] was *induced* equally by IFN and , but TNF generated higher levels of PAI-2 . Positive_regulation PLAU TNF 1338337 209133 and LPS *inhibited* both CSF-1 stimulated [urokinase-type plasminogen activator] ( u-PA ) mRNA levels and u-PA activity in BMM , whereas IFN gamma lowered only the u-PA activity . Positive_regulation PLAU TNF 1381189 196033 Recent observations have indicated that can *promote* the expression , synthesis and secretion of [urokinase plasminogen activator (uPA)] in low passage human umbilical vein endothelial cells which normally synthesize little uPA . Positive_regulation PLAU TNF 1381189 196035 ( 100 U/ml ) treatment of endothelial cultures *induced* steady state levels of [uPA] and PAI-1 mRNA following a 18 hr treatment both 6-fold and 2-fold , respectively utilizing northern analysis . Positive_regulation PLAU TNF 15183452 1255973 We also demonstrate that both and VEGF *induce* upregulated expression of [urokinase-type plasminogen activator] ( u-PA ) . Positive_regulation PLAU TNF 16171572 1457367 *induced* a time and concentration dependent activation of the [urokinase type plasminogen activator] ( u-PA ) and tissue type plasminogen activator (t-PA) activity in A549 cells . Positive_regulation PLAU TNF 1732009 181429 *induction* of endothelial cell [urokinase-type plasminogen activator] mediated proteolysis of extracellular matrix and its antagonism by gamma-interferon . Positive_regulation PLAU TNF 1732009 181430 Recent observations have indicated that can *promote* the synthesis and secretion of [urokinase plasminogen activator (uPA)] in low passage human endothelial cells that normally release little uPA . Positive_regulation PLAU TNF 1732009 181431 In this report we have confirmed and expanded upon these initial observations in human endothelial cells and describe the ability of gamma-interferon ( gamma-IFN ) to inhibit *induced* [uPA] synthesis and secretion in a dose dependent manner ( 0.025 to 25 ng/mL ) . Positive_regulation PLAU TNF 1801706 176949 *induction* of [urokinase-type plasminogen activator] in human endothelial cells . Positive_regulation PLAU TNF 1801706 176950 The *induction* of [uPA] by was inhibited by actinomycin D and cycloheximide implying the necessity of RNA and protein synthesis , respectively . Positive_regulation PLAU TNF 1905804 161648 Transcription of the human [urokinase type plasminogen activator] ( uPA ) gene in HeLa cells is *induced* by phorbol myristate acetate ( PMA ) , interleukin-1 (IL-1) and . Positive_regulation PLAU TNF 1905804 161657 Our results suggest that maximal transcriptional *activation* of the [uPA] gene by PMA , IL-1 and requires the induction of NFkB activity and the decay of a short lived repressor protein , possibly IkB . Positive_regulation PLAU TNF 20804741 2341699 *induces* expression of [urokinase-type plasminogen activator] and ß-catenin activation through generation of ROS in human breast epithelial cells . Positive_regulation PLAU TNF 20804741 2341702 siRNA knock down of ß-catenin abrogated *induced* [uPA] expression as well as Tcf-4/ß-catenin DNA binding . Positive_regulation PLAU TNF 20804741 2341703 *induced* expression of [uPA] and activation of ß-catenin signaling appear to be mediated by ROS in MCF-10A cells , as both events were blocked by the antioxidant N-acetylcysteine . Positive_regulation PLAU TNF 22166006 2536644 PMA , LPS , and , as well as uPA itself , *induce* [uPA] expression in lung epithelial cells . Positive_regulation PLAU TNF 22166006 2536646 PMA , LPS , and *induce* [uPA] expression through increased synthesis as well as stabilization of uPA mRNA , while uPA increases its own expression solely through uPA mRNA stabilization . Positive_regulation PLAU TNF 23221158 2707928 In the presence of another inflammatory cytokine , interleukin 1ß ( IL-1ß , 100 pg/mL ) , *stimulated* expression of uPA mRNA and secretion of [uPA] were enhanced . Positive_regulation PLAU TNF 7683925 216578 Role of protein kinase C in *induction* of endothelial cell [urokinase-type plasminogen activator] . Positive_regulation PLAU TNF 7683925 216579 In this report , the role of the protein kinase C ( PKC ) pathway in mediating *induction* of [uPA] in human umbilical vein endothelial cells is described . Positive_regulation PLAU TNF 7683925 216580 The PKC inhibitors ( H-7 , staurosporine , and calphostin C ) , but not HA-1004 , inhibited *induced* [uPA] expression , synthesis , and secretion in a dose dependent manner . Positive_regulation PLAU TNF 7683925 216581 The effect of PKC inhibitors was specific for *mediated* increased [uPA] expression because cytokine induction of PAI-1 was not influenced by these agents . Positive_regulation PLAU TNF 7683925 216582 This effect was specific for PMA because 4-alpha PMA pretreatment of cells , which does not stimulate PKC , was ineffective in altering *induction* of endothelial cell [uPA] . Positive_regulation PLAU TNF 7683925 216583 In summary , these data implicate a role for the PKC pathway in the *mediated* induction of [uPA] expression , subsequent matrix remodeling , and the formation of tube-like structures , a process important in neovascularization , wound healing , and leukocyte extravasation . Positive_regulation PLAU TNF 7906155 240344 treatment of human umbilical vein endothelial ( HUVE ) cells *induced* [urokinase-type plasminogen (uPA)] activity , increased HUVE uPA dependent extracellular matrix (ECM) degradation , and accelerated matrix remodeling and endothelial differentiation into tubes or cord-like structures . Positive_regulation PLAU TNF 7957773 278097 Effect of radical scavengers on *mediated* activation of the [uPA] in cultured cells . Positive_regulation PLAU TNF 7957773 278099 *increased* the steady state level of [urokinase-type plasminogen activator] ( uPA ) , and NAC inhibited this increase at a dose that also inhibited the increase in the intracellular oxidation state . Positive_regulation PLAU TNF 7957773 278101 PDTC , on the other hand , did not affect the *induction* of the [uPA] gene by . Positive_regulation PLAU TNF 7957773 278102 These results suggest that intracellular glutathione level rather than the oxidation state is necessary for the *induction* of the [uPA] gene by . Positive_regulation PLAU TNF 8088923 271676 *enhances* [urokinase-plasminogen activator (u-PA)] activity and steady-state mRNA levels twofold without affecting tissue-plasminogen activator (t-PA) or PAI-1 . Positive_regulation PLAU TNF 8356923 227521 Recent observations have indicated that and lymphotoxin ( TNF beta ) can *promote* the expression , synthesis and secretion of [urokinase plasminogen activator (uPA)] in human endothelial cells . Positive_regulation PLAU TNF 8679225 372509 Phorbol myristate acetate , lipopolysaccharide , transforming growth factor-beta ( TGF-beta ) , and *increased* [uPA] binding and plasminogen activation at the cell surface , with a greater maximal effect on fibrotic than on normal fibroblasts . Positive_regulation PLAU TNF 8772229 344227 Recombinant IL-1 alpha , recombinant IL-1 beta and LPS but not recombinant IL-6 , recombinant and TGF beta dose-dependently *increased* [uPA] accumulation in the conditioned medium . Positive_regulation PLAU TNF 8804426 382180 Using the protein synthesis inhibitor cycloheximide and the antioxidant PDTC , that have an opposite effect on NF-kappa B and AP-1 activation , we showed that [uPA] mRNA *induction* by and PMA in the A549 cell line is mainly due to NF-kappa B activation . Positive_regulation PLAU TNF 8826848 385273 and interleukin-1 beta (IL-1 beta) *increased* in several , but not all , cell lines the production of [urokinase-type plasminogen activator] ( uPA ) , tissue-type PA (tPA) and plasminogen activator inhibitor type 1 ( PAI-1 ) as analysed by zymography , enzyme immunoassays and Northern analysis . Positive_regulation PLAU TNF 8980909 403754 The effect of UTI on *induced* stimulation of [urokinase-type plasminogen activator] ( uPA ) in cultured human umbilical vein endothelial cells ( HUVEC ) and in the promyeloid leukemia U937 cells was studied . Positive_regulation PLAU TNF 8980909 403755 The PKC inhibitors ( H7 , calphostin C , and staurosporine ) inhibited *induced* [uPA] expression and secretion in a dose dependent manner . Positive_regulation PLAU TNF 8980909 403756 Analysis of the expression of cell surface receptor bound uPA by flow cytometry using uPA-specific MAb indicates that *induction* of [uPA] expression by was inhibited when these cells were incubated with UTI . Positive_regulation PLAU TNF 9454892 484432 We conclude that UTI suppresses tumor cell invasion and metastasis by a mechanism that UTI inhibits *stimulated* [uPA] production via a PKC dependent mechanism . Positive_regulation PLAU TNF 9688934 522681 The secretion of [uPA] and plasminogen activator inhibitor-1 from HLMECs was also *enhanced* by and IL-2 . Positive_regulation PLAU TNFSF10 18397859 1893688 The purpose of this study was to find out if could *induce* the expression of [uPA] , IL-8 , MMP-7 and MMP-9 .and to explore the corresponding potential signaling transduction pathway in pancreatic cancer cells . Positive_regulation PLAU TNFSF10 18397859 1893691 can *stimulate* the expression of [uPA] , IL-8 , MMP-7 and MMP-9 in pancreatic cancer cell lines , especially in Colo357wt . Positive_regulation PLAU TNFSF10 18397859 1893694 The members of caspases , MEK1/2 , PKC , and NF-kappaB are involved in *induced* expression of [uPA] , IL-8 , MMP-7 and MMP-9 . Positive_regulation PLAU TNFSF10 23392805 2739920 *induced* expression of [uPA] and IL-8 strongly enhanced by overexpression of TRAF2 and Bcl-xL in pancreatic ductal adenocarcinoma cells . Positive_regulation PLAU TNFSF10 23392805 2739937 Overexpression of TRAF2 or Bcl-xL strongly increased *mediated* upregulation of [uPA] and IL-8 . Positive_regulation PLAU TNFSF10 23392805 2739941 In PDAC cells , strongly *induced* [uPA] and IL-8 via TRAIL-R1 . Positive_regulation PLAU TP53 23665346 2800803 We used a mouse model of bleomycin (BLM) induced lung injury to understand the involvement of *mediated* changes in [urokinase-type plasminogen activator] ( uPA ) and plasminogen activator inhibitor-1 ( PAI-1 ) levels in the regulation of alveolar epithelial injury . Positive_regulation PLAU TPR 9038378 415571 We found that efficiently *activates* the [uPA] gene via a SOS/Ras/extracellular signal regulated kinase ( ERK ) -dependent signaling pathway . Positive_regulation PLAU VEGFA 11500940 847159 ( d ) FGF-2 induced urokinase-type PA (uPA) in BME and BAE cells , while *induced* [uPA] and tissue-type PA in BME cells with no effect on BAE cells . Positive_regulation PLAU VEGFA 12761886 1091760 In conclusion , these data suggest that genistein , apigenin , and 3-hydroxyflavone inhibit in vitro angiogenesis , in part via preventing *induced* MMP-1 and [uPA] expression and the activation of pro-MMP-2 , and via modulating their inhibitors , TIMP-1 and -2 , and PAI-1 . Positive_regulation PLAU VEGFA 14525763 1185782 This *induced* [pro-uPA] activation on endothelial cells is responsible for VEGF dependent local fibrinolytic activity and might be one of the initial steps in the angiogenic process . Positive_regulation PLAU VEGFA 14644771 1210222 We have further demonstrated that *stimulated* the expression of PAI-1 , but not [urokinase plasminogen activator (uPA)] , in keloid fibroblasts at both mRNA and protein levels , in a dose- and time dependent manner . Positive_regulation PLAU VEGFA 15183452 1255974 We also demonstrate that both TNF-alpha and *induce* upregulated expression of [urokinase-type plasminogen activator] ( u-PA ) . Positive_regulation PLAU VEGFA 16388516 1533441 Specifically , emodin induces the cell cycle arrest of HUVECs in the G0/G1 phase by suppressing cyclin D1 and E expression and retinoblastoma protein phosphorylation , and suppresses Matrigel invasion by inhibiting the basal secretion of matrix metalloproteinase-2 and *stimulated* [urokinase plasminogen activator] receptor expression . Positive_regulation PLAU VEGFA 17359337 1712599 TAPS significantly inhibited *induced* proteolytic enzyme production , including matrix metalloproteinase-2 , [urokinase-type plasminogen activator] and plasminogen activator inhibitor-1 . Positive_regulation PLAU VEGFA 21304816 2388555 then *activated* [uPA] in co-cultured HUVEC , which might be responsible for initiating the migration and the self assembled network formation with the participation of VE-cad . Positive_regulation PLAU VEGFA 7730348 302278 Here , we report that *increases* the high affinity binding of [uPA] to the same cells and that this binding is prevented by a peptide corresponding to the uPA receptor (uPAR) binding growth factor-like domain of uPA . Positive_regulation PLAU VEGFA 9378778 465696 In both BME and BAE cells , antibodies to bFGF also decreased basal levels of cell associated uPA activity , and completely blocked the mediated *increase* in [uPA] and tPA expression observed in parallel cultures incubated with VEGF alone . Positive_regulation PLAU VTN 11495705 846373 Free and immobilized and fibronectin *stimulated* the proliferation of cells under serum-free conditions and the production and release of [urokinase-type plasminogen activator] , and increased the release of the activated forms of matrix metalloproteinase-2 and matrix metalloproteinase-9 in an alpha(v)beta(3) integrin dependent manner . Positive_regulation PLAU VTN 1377687 190518 *regulates* the synthesis and localization of [urokinase-type plasminogen activator] in HT-1080 cells . Positive_regulation PLAU VTN 17344041 1740992 Our results indicate that *dependent* localization of [uPA] to adhesion sites requires the sequential binding of vitronectin integrins and uPAR to vitronectin . Positive_regulation PLAU VTN 9164658 406994 These data demonstrate that the synthesis of and its matrix association by transfected HT-1080 fibrosarcoma cells *results* in localization of [uPA] to alpha v beta 5 containing focal adhesions , decreased cell surface uPA activity , and an increase in cell adhesion . Positive_regulation PLAU WDR61 15149885 1248450 Activation of receptor by oxidised LDL in human monocytes *stimulates* chemokine releases but not [urokinase-type plasminogen activator] expression . Positive_regulation PLAU WDR61 15149885 1248469 Our results indicated that oxidation products are responsible for the monocyte chemokine releases , but did not *contribute* to the enhanced monocyte [uPA] expression by oxidised LDL . Positive_regulation PLAU WDR61 9185044 436696 We have found that in the cornea , a potent lipid inflammatory mediator *activates* the expression of two metalloproteinases ( MMP-1 and MMP-9 ) as well as [urokinase-plasminogen activator (uPA)] . Positive_regulation PLAU WNT1 23340304 2747448 Optimal *induction* of [uPA] by signaling requires ZEB1 expression . Positive_regulation PLAU WNT11 23340304 2747449 Optimal *induction* of [uPA] by signaling requires ZEB1 expression . Positive_regulation PLAU WNT16 23340304 2747454 Optimal *induction* of [uPA] by signaling requires ZEB1 expression . Positive_regulation PLAU WNT2 23340304 2747450 Optimal *induction* of [uPA] by signaling requires ZEB1 expression . Positive_regulation PLAU WNT3 23340304 2747451 Optimal *induction* of [uPA] by signaling requires ZEB1 expression . Positive_regulation PLAU WNT4 23340304 2747452 Optimal *induction* of [uPA] by signaling requires ZEB1 expression . Positive_regulation PLAU WNT6 23340304 2747453 Optimal *induction* of [uPA] by signaling requires ZEB1 expression . Positive_regulation PLAU ZEB1 23340304 2747432 Through multiple experimental approaches , colorectal carcinoma ( CRC ) cell lines and samples from human primary CRC and ZEB1 ( -/- ) mice were used to examine *mediated* regulation of [uPA] and PAI-1 at the protein , mRNA , and transcriptional level . Positive_regulation PLAU ZEB1 23340304 2747436 *regulates* [uPA] and PAI-1 in opposite directions : induces uPA and inhibits PAI-1 . Positive_regulation PLAU ZEB1 23340304 2747447 Optimal induction of [uPA] by Wnt signaling *requires* expression . Positive_regulation PLAUR EPHB2 15389548 1304768 Like NFLC , induction of [urokinase plasminogen activator (uPAR)] , transin/matrix metalloproteinase 3 (MMP3) , Fra-1 and transforming growth factor beta 1 ( TGF beta 1 ) *required* collaborative and JNK signaling while the increased expression of cortexin , rat collapsin response mediator protein 4 ( rCRMP4 ) , rat growth and transformation dependent protein ( RGT ) , and synapsin II required neither mitogen activated protein kinase (MAPK) pathway . Positive_regulation PLAUR EPHB2 16467878 1523609 These results demonstrated that [uPAR] is induced by hypoxia and that increased uPAR expression is *mediated* by phosphorylation , which in turn is modulated by iNOS/NO in MDA-MB-231 cells . Positive_regulation PLAUR EPHB2 17427199 1748791 *dependent* [uPAR] expression is required for motility via phosphorylation of P70S6K in human hepatocarcinoma cells . Positive_regulation PLAUR EPHB2 18495808 1933714 In a 3-D system , we found that not only [uPA-uPAR] association but also the *activation* of were inhibited by HKa . Positive_regulation PLAUR EPHB2 18762175 1975471 Inhibition of PKC-and *resulted* in a strong down-regulation of basal [uPAR] expression whereas the FFA induced up-regulation remained unchanged . Positive_regulation PLAUR EPHB2 19433314 2077921 Interestingly , [uPAR] protein expression was *suppressed* by inhibition and stimulated with p-p38 inhibition , suggesting the presence of a positive feedback loop between uPAR and ERK . Positive_regulation PLAUR EPHB2 21803847 2484751 We also demonstrated that VEGF dependent phosphorylation *required* integrity of caveolae as well as caveolar [uPAR] expression . Positive_regulation PLAUR IL1B 11238529 790741 We investigated the *role* of in regulating u-PA , PAI-1 , [u-PAR] , and soluble u-PAR messenger ribonucleic acid ( mRNA ) expression in cultured human endometrial stromal cells using quantitative competitive PCR . Positive_regulation PLAUR IL1B 11238529 790744 *increased* PAI-1 , [u-PAR] , and soluble u-PAR expression in a dose dependent manner , and this result was reversed by anti-IL-1beta antibody treatment . Positive_regulation PLAUR IL1B 11758807 887686 In addition , *increased* the protein and mRNA levels of both uPA and [uPAR] in gingival fibroblasts . Positive_regulation PLAUR IL1B 11758807 887688 These findings suggest that the *enhancement* of uPA and [uPAR] levels by may play an important role in the progression of periodontal diseases through pericellular proteolysis , and subsequent cellular behavior . Positive_regulation PLAUR IL1B 14702177 1196122 We found an *mediated* expression of [uPAR] by immunoelectron microscopy . Positive_regulation PLAUR IL1B 14702177 1196123 Western blot analysis demonstrated that *stimulated* expression of [uPAR] on chondrocytes in vitro increased in a dose dependent manner . Positive_regulation PLAUR MAP2K6 17427199 1748797 *dependent* [uPAR] expression is required for motility via phosphorylation of P70S6K in human hepatocarcinoma cells . Positive_regulation PLAUR MAP2K6 20089873 2258702 In addition , the VEGF induced transcriptional activation of beta-catenin and [uPAR] expression were *blocked* by PEDF and by inhibitors of p38 and . Positive_regulation PLAUR PLAT 15231724 1289415 The sphingomyelin/ceramide pathway is involved in ERK1/2 phosphorylation , cell proliferation , and [uPAR] overexpression *induced* by . Positive_regulation PLAUR PLAU 10090848 600279 Additionally , antisense [uPAR] inhibition *induced* a 68-70 % reduction in and plasmin activities . Positive_regulation PLAUR PLAU 10190285 603363 Chemotaxis is induced through an *dependent* conformational change in [uPAR] which uncovers a very potent chemotactic epitope acting through a pertussis-toxin sensitive step and activating intracellular tyrosine kinases . Positive_regulation PLAUR PLAU 11342540 827700 The *mediated* induction of [uPAR] is not accomplished through its receptor and requires enzymatic activity . Positive_regulation PLAUR PLAU 11728456 884661 Moreover , *dependent* [uPAR] up-regulation correlates with the increase of a complex between the coding region of uPAR mRNA and an unknown cellular factor . Positive_regulation PLAUR PLAU 11728456 884662 We then propose that *regulates* [uPAR] expression at a post-transcriptional level , by promoting the binding of uPAR mRNA to a stabilizing factor . Positive_regulation PLAUR PLAU 12704669 1082384 We show that is able to *increase* [uPAR] expression , both at protein and mRNA levels , in primary cell cultures obtained from tumor and adjacent normal lung tissues of patients affected by NSCLC , thus suggesting that the enzyme can exert its effect in lung cells . Positive_regulation PLAUR PLAU 12704669 1082385 We then suggest that *regulates* [uPAR] expression in NSCLC at a posttranscriptional level by increasing uPAR-stability through a cellular factor that binds the coding region of uPAR-mRNA . Positive_regulation PLAUR PLAU 12754207 1113094 signaling *requires* its binding to uPA receptor ( [uPAR/CD87] ) , but how glycosylphosphatidylinositol anchored uPAR mediates signaling is unclear . Positive_regulation PLAUR PLAU 12754207 1113095 We studied whether binding of [uPAR] to alpha 5 beta 1 in cis is involved in adhesion and migration of Chinese hamster ovary cells in *response* to immobilized . Positive_regulation PLAUR PLAU 12754207 1113098 We demonstrated that *induced* RGD dependent binding of [uPAR] to alpha 5 beta 1 in solution . Positive_regulation PLAUR PLAU 12952933 1137485 The constitutively recycling endocytic receptor Endo180 forms a trimolecular complex with [uPAR] in the *presence* of , hence its alternate name uPAR associated protein . Positive_regulation PLAUR PLAU 15889147 1407280 We provide evidence that [uPAR] *activation* by induces its association with platelet derived growth factor receptor ( PDGFR)-beta . Positive_regulation PLAUR PLAU 16143315 1461261 Accordingly , both *dependent* enhancement of [uPAR] expression and cell migration were strongly reduced in transfected cells . Positive_regulation PLAUR PLAU 16267271 1502090 wt-uPAR requires both integrins and FPRL1 to mediate *induced* migration , and association of [wt-uPAR] to alpha3beta1 results in uPAR cleavage and extracellular signal regulated kinase ( ERK ) activation . Positive_regulation PLAUR PLAU 16391791 1505824 Furthermore , significantly *induced* the expression of plasmin(ogen) and [uPAR] in the conditioned medium of non dissociated ( PC-1 ) pancreatic cancer cells . Positive_regulation PLAUR PLAU 16618739 1551075 The maspin effects on surface associated uPA and [uPAR] *required* the interaction between and uPAR . Positive_regulation PLAUR PLAU 16923171 1603120 Over-expression of in the VTA *induces* doxycycline dependent expression of its receptor , [uPAR] , but not its inhibitor , plasminogen activator inhibitor-1 ( PAI-1 ) . Positive_regulation PLAUR PLAU 17134505 1661448 Based on the efficient activation of plasminogen when uPA is bound to its receptor (uPAR) and on the role of uPA in plasmin mediated liver repair , we hypothesized that *requires* [uPAR] for efficient liver repair . Positive_regulation PLAUR PLAU 17134505 1661455 Absence of uPAR alone or the combined absence of [uPAR] and tPA had no impact on the resolution of centrilobular injury , but the loss of receptor-free significantly *impaired* the clearance of necrotic hepatocytes up to 14 days after CCl4 . Positive_regulation PLAUR PLAU 17186542 1701677 These results indicate that expression of [uPAR] *requires* but not vice versa . Positive_regulation PLAUR PLAU 17186542 1701679 Finally , we provided evidence that Fyn , a Src family kinase , is involved in *induced* [uPAR] expression . Positive_regulation PLAUR PLAU 17344041 1740994 Our results indicate that vitronectin dependent localization of to adhesion sites *requires* the sequential binding of vitronectin integrins and [uPAR] to vitronectin . Positive_regulation PLAUR PLAU 17549401 1752560 From our in vitro experiments , we have observed that plasmid based RNAi mediated down-regulation of uPAR and in SNB19 human glioma cells *caused* a decrease in the levels of [uPAR] protein and uPA enzyme activities . Positive_regulation PLAUR PLAU 17963689 1850027 binding *increases* [UPAR] localization to lipid rafts and modifies the receptor microdomain composition . Positive_regulation PLAUR PLAU 18279442 1878263 In culture , *increased* lymphocyte proliferation significantly in WT and uPA-/- but not [uPAR-/-] animals . Positive_regulation PLAUR PLAU 18494499 1921834 These observations indicate that hnRNPC could be involved in the *induction* of [uPAR] expression by . Positive_regulation PLAUR PLAU 18494499 1921835 Increased hnRNPC interaction with the uPAR mRNA 3'-UTR through phosphorylation of Y57 represents a novel mechanism by which *regulates* posttranscriptional uPAR mRNA turnover and cell surface [uPAR] expression . Positive_regulation PLAUR PLAU 18564064 1959165 Effects of were independent of its proteolytic activity and *required* [uPAR] for both pro- and anti-apoptotic effects . Positive_regulation PLAUR PLAU 18836029 1993847 further *mediates* its own expression in these cells as well as that of [uPAR] and PAI-1 through induction of changes in mRNA stability . Positive_regulation PLAUR PLAU 19029002 2029307 To determine the *role* of in [uPAR] expression during ALI caused by sepsis . Positive_regulation PLAUR PLAU 19735728 2147188 In conclusion , *triggers* interaction between integrin alpha(v)beta(3) , [uPAR] and MMPs that leads to NSMase-2 and ERK1/2 activation and cell proliferation . Positive_regulation PLAUR PLAU 19784757 2195681 In contrast , inhibition of tyrosine phosphorylation augments PGK binding to uPAR mRNA and attenuates *induced* [uPAR] expression . Positive_regulation PLAUR PLAU 19784757 2195682 Inhibition of tyrosine phosphorylation by mutating Y76 residue abolished [uPAR] expression *induced* by treatment . Positive_regulation PLAUR PLAU 21465475 2523644 The effect of on SK-Hep-1 signaling and SDF-1 expression is *mediated* by [uPAR] . Positive_regulation PLAUR PLAU 23060546 2685566 MDSC can be recruited by , and [uPAR] but not CD11b are *required* for such recruitment . Positive_regulation PLAUR PLAU 8830783 385625 Taken together , these results suggest a dynamic regulatory *role* for PAI-1 and in [uPAR] mediated cell adhesion and release . Positive_regulation PLAUR PLAU 9270032 450174 Using our syngeneic model of uPAR overexpression by the rat breast cancer cell line Mat B-III , we have examined the ability of the nonsteroidal antiestrogen , tamoxifen ( TAM ) , and of a selective synthetic inhibitor of , 4-iodo benzo [ b ] thiophene-2-carboxamidine ( B-428 ) , to *inhibit* expression of uPA and [uPAR] as well as cell growth , invasion , and metastasis of wild-type Mat B-III cells and of cells overexpressing uPAR ( Mat B-III-uPAR ) . Positive_regulation PLAUR PLAU 9821967 548700 Dependence of uPA provoked cell proliferation on uPAR was further demonstrated in Raji cells which do not express [uPAR] and were thus not *induced* by . Positive_regulation PLAUR PLAU 9848876 554082 These data suggest that stimulates adhesion of SMCs specifically to vitronectin and that it is *mediated* by an interaction with [uPAR] . Positive_regulation PLAUR SELL 11290756 800671 To examine the *role* of in [uPAR] mediated signaling , uPAR was cross linked and intracellular Ca ( 2+ ) concentrations were measured by spectrofluorometry . Positive_regulation PLAUR SORL1 14764453 1227334 Thus , *mediates* the [uPAR] localization to the plasma membrane . Positive_regulation PLAUR TLR7 21998707 2493781 However , it is unclear if [uPAR] has direct involvement in the *response* of inflammatory cells , such as neutrophils and macrophages , to stimulation . Positive_regulation PLAUR TNF 7867787 296511 Nuclear run-on transcription assays indicated that uPA mRNA was modulated by butyrate at the transcriptional level but the [uPAR] gene was regulated at both transcriptional and post-transcriptional levels in the *presence* or absence of . Positive_regulation PLAUR TNF 8049441 267473 By contrast , *induced* a 2.5-fold increase in the level of [uPAR] protein released into conditioned medium ( compared with unstimulated cells ) , whereas IFN gamma had no effect . Positive_regulation PLAUR TNF 8298141 248433 We have previously shown that uPAR is expressed on the plasma membrane of circulating neutrophils , and we now report that stimulation with phorbol myristate acetate ( PMA ) , FMLP , or *results* in a rapid increase in the expression of [uPAR] . Positive_regulation PLAUR TNF 8601593 351902 bFGF and VEGF165 enhanced of the [u-PAR] by 72 and 46 % , but itself also *increased* u-PAR in hMVEC by 30 % . Positive_regulation PLCB1 EDN2 12196532 997886 In contrast , pressor hormones like arginine-vasopressin , angiotensin II , and bind serpentine receptors that interact with G ( q ) and *activate* [phospholipase Cbeta] . Positive_regulation PLCB1 EPHB2 11287604 800199 Expression of S982G was found to inhibit *mediated* phosphorylation of endogenous [PLC beta1] . Positive_regulation PLCB1 GPR115 10456177 638837 Binding of GnRH to a *leads* to stimulation of Gq and/or G11 protein and to activation of [phospholipase C beta] . Positive_regulation PLCB1 GPR115 10508586 650075 Thus , membrane localised cRaf1 inhibits *stimulated* activation of [phospholipase Cbeta (PLCbeta)] by sequestration of Gbetagamma subunits , an effect also observed with endogenous levels of cRaf1 . Positive_regulation PLCB1 GPR115 20146267 2281033 These results show that the putative on the plasma membrane senses the IP6 hydrolysates and *activates* [phospholipase Cbeta] , resulting in Ca ( 2+ ) mobilization through Ca ( 2+ ) channels coupled with the inositol 1 , 4 , 5 tri-phosphate and ryanodine receptors on the sarco-endoplasmic reticulum Ca ( 2+ ) store in colorectal cancer cells . Positive_regulation PLCB1 GPR132 10456177 638826 Binding of GnRH to a *leads* to stimulation of Gq and/or G11 protein and to activation of [phospholipase C beta] . Positive_regulation PLCB1 GPR132 10508586 650064 Thus , membrane localised cRaf1 inhibits *stimulated* activation of [phospholipase Cbeta (PLCbeta)] by sequestration of Gbetagamma subunits , an effect also observed with endogenous levels of cRaf1 . Positive_regulation PLCB1 GPR132 20146267 2281022 These results show that the putative on the plasma membrane senses the IP6 hydrolysates and *activates* [phospholipase Cbeta] , resulting in Ca ( 2+ ) mobilization through Ca ( 2+ ) channels coupled with the inositol 1 , 4 , 5 tri-phosphate and ryanodine receptors on the sarco-endoplasmic reticulum Ca ( 2+ ) store in colorectal cancer cells . Positive_regulation PLCB1 GPR87 10456177 638907 Binding of GnRH to a *leads* to stimulation of Gq and/or G11 protein and to activation of [phospholipase C beta] . Positive_regulation PLCB1 GPR87 10508586 650144 Thus , membrane localised cRaf1 inhibits *stimulated* activation of [phospholipase Cbeta (PLCbeta)] by sequestration of Gbetagamma subunits , an effect also observed with endogenous levels of cRaf1 . Positive_regulation PLCB1 GPR87 20146267 2281102 These results show that the putative on the plasma membrane senses the IP6 hydrolysates and *activates* [phospholipase Cbeta] , resulting in Ca ( 2+ ) mobilization through Ca ( 2+ ) channels coupled with the inositol 1 , 4 , 5 tri-phosphate and ryanodine receptors on the sarco-endoplasmic reticulum Ca ( 2+ ) store in colorectal cancer cells . Positive_regulation PLCB1 MAP2K6 11287604 800195 Stimulation of Swiss 3T3 cells with insulin-like growth factor I (IGF-I) caused rapid nuclear translocation of activated ERK and concurrently induced phosphorylation of nuclear [PLC beta1] , which was completely *blocked* by the inhibitor PD 98059 . Positive_regulation PLCB1 RAB31 9307015 454370 P1 also activated recombinant PLC-beta1 , indicating direct *activation* of [PLC-beta1] by effector-domain peptides . Positive_regulation PLCB2 EDN2 12196532 997889 In contrast , pressor hormones like arginine-vasopressin , angiotensin II , and bind serpentine receptors that interact with G ( q ) and *activate* [phospholipase Cbeta] . Positive_regulation PLCB2 F2R 12716374 1083719 These studies provide evidence that , in human platelets , both Galphaq and PLC-beta2 play a major role in *responses* to and PAR4 activation , and that [PLC-beta2] is required for the sustained Ca2+ rise upon thrombin activation . Positive_regulation PLCB2 GPR115 10456177 638931 Binding of GnRH to a *leads* to stimulation of Gq and/or G11 protein and to activation of [phospholipase C beta] . Positive_regulation PLCB2 GPR115 10508586 650168 Thus , membrane localised cRaf1 inhibits *stimulated* activation of [phospholipase Cbeta (PLCbeta)] by sequestration of Gbetagamma subunits , an effect also observed with endogenous levels of cRaf1 . Positive_regulation PLCB2 GPR115 20146267 2281126 These results show that the putative on the plasma membrane senses the IP6 hydrolysates and *activates* [phospholipase Cbeta] , resulting in Ca ( 2+ ) mobilization through Ca ( 2+ ) channels coupled with the inositol 1 , 4 , 5 tri-phosphate and ryanodine receptors on the sarco-endoplasmic reticulum Ca ( 2+ ) store in colorectal cancer cells . Positive_regulation PLCB2 GPR132 10456177 638920 Binding of GnRH to a *leads* to stimulation of Gq and/or G11 protein and to activation of [phospholipase C beta] . Positive_regulation PLCB2 GPR132 10508586 650157 Thus , membrane localised cRaf1 inhibits *stimulated* activation of [phospholipase Cbeta (PLCbeta)] by sequestration of Gbetagamma subunits , an effect also observed with endogenous levels of cRaf1 . Positive_regulation PLCB2 GPR132 20146267 2281115 These results show that the putative on the plasma membrane senses the IP6 hydrolysates and *activates* [phospholipase Cbeta] , resulting in Ca ( 2+ ) mobilization through Ca ( 2+ ) channels coupled with the inositol 1 , 4 , 5 tri-phosphate and ryanodine receptors on the sarco-endoplasmic reticulum Ca ( 2+ ) store in colorectal cancer cells . Positive_regulation PLCB2 GPR87 10456177 639001 Binding of GnRH to a *leads* to stimulation of Gq and/or G11 protein and to activation of [phospholipase C beta] . Positive_regulation PLCB2 GPR87 10508586 650237 Thus , membrane localised cRaf1 inhibits *stimulated* activation of [phospholipase Cbeta (PLCbeta)] by sequestration of Gbetagamma subunits , an effect also observed with endogenous levels of cRaf1 . Positive_regulation PLCB2 GPR87 20146267 2281195 These results show that the putative on the plasma membrane senses the IP6 hydrolysates and *activates* [phospholipase Cbeta] , resulting in Ca ( 2+ ) mobilization through Ca ( 2+ ) channels coupled with the inositol 1 , 4 , 5 tri-phosphate and ryanodine receptors on the sarco-endoplasmic reticulum Ca ( 2+ ) store in colorectal cancer cells . Positive_regulation PLCB2 JAG1 17446173 1760959 *stimulates* activation of [phospholipase C beta2] by heterotrimeric Galphabetagamma and forms a quaternary complex with Galpha ( i1 ) , Gbeta ( 1 ) gamma ( 2 ) , and phospholipase C beta2 . Positive_regulation PLCB3 EDN2 12196532 997892 In contrast , pressor hormones like arginine-vasopressin , angiotensin II , and bind serpentine receptors that interact with G ( q ) and *activate* [phospholipase Cbeta] . Positive_regulation PLCB3 EPHB2 10944430 722865 The upregulation of [PLCbeta3] by IGF-I is *dependent* on the activity of tyrosine kinase , , PI3 kinase , and p70 S6 kinase and PLCbeta3 expression seems to be required for the induction of immediate early genes by IGF-I . Positive_regulation PLCB3 GPR115 10456177 639025 Binding of GnRH to a *leads* to stimulation of Gq and/or G11 protein and to activation of [phospholipase C beta] . Positive_regulation PLCB3 GPR115 10508586 650261 Thus , membrane localised cRaf1 inhibits *stimulated* activation of [phospholipase Cbeta (PLCbeta)] by sequestration of Gbetagamma subunits , an effect also observed with endogenous levels of cRaf1 . Positive_regulation PLCB3 GPR115 20146267 2281219 These results show that the putative on the plasma membrane senses the IP6 hydrolysates and *activates* [phospholipase Cbeta] , resulting in Ca ( 2+ ) mobilization through Ca ( 2+ ) channels coupled with the inositol 1 , 4 , 5 tri-phosphate and ryanodine receptors on the sarco-endoplasmic reticulum Ca ( 2+ ) store in colorectal cancer cells . Positive_regulation PLCB3 GPR132 10456177 639014 Binding of GnRH to a *leads* to stimulation of Gq and/or G11 protein and to activation of [phospholipase C beta] . Positive_regulation PLCB3 GPR132 10508586 650250 Thus , membrane localised cRaf1 inhibits *stimulated* activation of [phospholipase Cbeta (PLCbeta)] by sequestration of Gbetagamma subunits , an effect also observed with endogenous levels of cRaf1 . Positive_regulation PLCB3 GPR132 20146267 2281208 These results show that the putative on the plasma membrane senses the IP6 hydrolysates and *activates* [phospholipase Cbeta] , resulting in Ca ( 2+ ) mobilization through Ca ( 2+ ) channels coupled with the inositol 1 , 4 , 5 tri-phosphate and ryanodine receptors on the sarco-endoplasmic reticulum Ca ( 2+ ) store in colorectal cancer cells . Positive_regulation PLCB3 GPR87 10456177 639095 Binding of GnRH to a *leads* to stimulation of Gq and/or G11 protein and to activation of [phospholipase C beta] . Positive_regulation PLCB3 GPR87 10508586 650330 Thus , membrane localised cRaf1 inhibits *stimulated* activation of [phospholipase Cbeta (PLCbeta)] by sequestration of Gbetagamma subunits , an effect also observed with endogenous levels of cRaf1 . Positive_regulation PLCB3 GPR87 20146267 2281288 These results show that the putative on the plasma membrane senses the IP6 hydrolysates and *activates* [phospholipase Cbeta] , resulting in Ca ( 2+ ) mobilization through Ca ( 2+ ) channels coupled with the inositol 1 , 4 , 5 tri-phosphate and ryanodine receptors on the sarco-endoplasmic reticulum Ca ( 2+ ) store in colorectal cancer cells . Positive_regulation PLCB4 EDN2 12196532 997895 In contrast , pressor hormones like arginine-vasopressin , angiotensin II , and bind serpentine receptors that interact with G ( q ) and *activate* [phospholipase Cbeta] . Positive_regulation PLCB4 GPR115 10456177 639119 Binding of GnRH to a *leads* to stimulation of Gq and/or G11 protein and to activation of [phospholipase C beta] . Positive_regulation PLCB4 GPR115 10508586 650354 Thus , membrane localised cRaf1 inhibits *stimulated* activation of [phospholipase Cbeta (PLCbeta)] by sequestration of Gbetagamma subunits , an effect also observed with endogenous levels of cRaf1 . Positive_regulation PLCB4 GPR115 20146267 2281312 These results show that the putative on the plasma membrane senses the IP6 hydrolysates and *activates* [phospholipase Cbeta] , resulting in Ca ( 2+ ) mobilization through Ca ( 2+ ) channels coupled with the inositol 1 , 4 , 5 tri-phosphate and ryanodine receptors on the sarco-endoplasmic reticulum Ca ( 2+ ) store in colorectal cancer cells . Positive_regulation PLCB4 GPR132 10456177 639108 Binding of GnRH to a *leads* to stimulation of Gq and/or G11 protein and to activation of [phospholipase C beta] . Positive_regulation PLCB4 GPR132 10508586 650343 Thus , membrane localised cRaf1 inhibits *stimulated* activation of [phospholipase Cbeta (PLCbeta)] by sequestration of Gbetagamma subunits , an effect also observed with endogenous levels of cRaf1 . Positive_regulation PLCB4 GPR132 20146267 2281301 These results show that the putative on the plasma membrane senses the IP6 hydrolysates and *activates* [phospholipase Cbeta] , resulting in Ca ( 2+ ) mobilization through Ca ( 2+ ) channels coupled with the inositol 1 , 4 , 5 tri-phosphate and ryanodine receptors on the sarco-endoplasmic reticulum Ca ( 2+ ) store in colorectal cancer cells . Positive_regulation PLCB4 GPR87 10456177 639189 Binding of GnRH to a *leads* to stimulation of Gq and/or G11 protein and to activation of [phospholipase C beta] . Positive_regulation PLCB4 GPR87 10508586 650423 Thus , membrane localised cRaf1 inhibits *stimulated* activation of [phospholipase Cbeta (PLCbeta)] by sequestration of Gbetagamma subunits , an effect also observed with endogenous levels of cRaf1 . Positive_regulation PLCB4 GPR87 20146267 2281381 These results show that the putative on the plasma membrane senses the IP6 hydrolysates and *activates* [phospholipase Cbeta] , resulting in Ca ( 2+ ) mobilization through Ca ( 2+ ) channels coupled with the inositol 1 , 4 , 5 tri-phosphate and ryanodine receptors on the sarco-endoplasmic reticulum Ca ( 2+ ) store in colorectal cancer cells . Positive_regulation PLCG1 AGR2 1380035 193121 The also *mediates* the activation of [phospholipase C-gamma 1] ( PLC-gamma 1 ) thus producing the second messengers , inositol trisphosphate and diacylglycerol . Positive_regulation PLCG1 EPHB2 10958690 726177 The PTEN-deficient cells were also hyperresponsive to T-cell receptor ( TCR ) stimulation , as measured by Itk kinase activity , tyrosine phosphorylation of [phospholipase C-gamma1] , and *activation* of compared to those in PTEN-replete cells . Positive_regulation PLCG1 EPHB2 17119112 1700618 Although RhoH is not required for TCR induced activation of ZAP70 and ZAP70 mediated activation of p38 , it is crucial for the tyrosine phosphorylation of LAT , [PLCgamma1] , and Vav1 and for the *activation* of and calcium influx . Positive_regulation PLCG1 EPHB2 17524370 1762101 HSV mediated overexpression of PLCgamma1 in PC12 cells induced ERK activation via a mechanism dependent , in part , on both MAP-ERK kinase (MEK) and protein kinase C . [PLCgamma1] overexpression in the VTA similarly *induced* activation in the VTA in vivo . Positive_regulation PLCG1 ITGAL 19542227 2116376 Using membrane vesicles expressing the mouse class I major histocompatibility complex , i.e. Ld plus costimulatory ligands , i.e . B7-1 and intercellular adhesion molecule-1 along with 2C T cell receptor transgenic T cells , we investigated the *roles* of CD28 and ( lymphocyte function associated antigen-1 ) in the activation of [PLC-gamma1] and Ca2+ signaling . Positive_regulation PLCG1 ITGB2 16002691 1431006 Experiments performed with specific inhibitors revealed that entry of HIV-1 in activated CD4 ( + ) T cells is regulated by *dependent* ZAP70 , [phospholipase Cgamma1] , and calpain enzymatic activities . Positive_regulation PLCG1 PLAU 8940113 398948 Induction of by fibroblast growth factor (FGF)-2 is dependent on expression of FGF receptors and does not *require* activation of [phospholipase Cgamma1] . Positive_regulation PLCG1 TNF 18079103 1874537 [PLCgamma1] signalling *induces* cardiac expression and myocardial dysfunction during LPS stimulation . Positive_regulation PLCG2 TNF 10946303 722960 These results suggest that , in NCI-H292 epithelial cells , might *activate* [phospholipase C-gamma2] via an upstream tyrosine kinase to induce activation of PKC-alpha and protein tyrosine kinase , resulting in the activation of NF-kappaB inducing kinase and IKK1/2 , and NF-kappaB in the COX-2 promoter , then initiation of COX-2 expression and PGE2 release . Positive_regulation PLCL1 GPR115 17998205 1851335 [Phospholipase Cepsilon] ( PLCepsilon ) is *activated* by various growth factors or ligands via different activation mechanisms . Positive_regulation PLCL1 GPR132 17998205 1851324 [Phospholipase Cepsilon] ( PLCepsilon ) is *activated* by various growth factors or ligands via different activation mechanisms . Positive_regulation PLCL1 GPR87 17998205 1851404 [Phospholipase Cepsilon] ( PLCepsilon ) is *activated* by various growth factors or ligands via different activation mechanisms . Positive_regulation PLD1 ANGPT1 12890486 1117393 Interestingly , *increased* [PLD] activities in a dose- and time dependent manner . Positive_regulation PLD1 EDN2 1537886 180643 Phorbol esters and synthetic diglycerides mimicked the effects of endothelin to stimulate phospholipase D and inhibitors of protein kinase C significantly reduced *stimulated* [phospholipase D] . Positive_regulation PLD1 EDN2 1537886 180661 The calcium ionophore , ionomycin , did not stimulate phospholipase D and mesangial cells pretreated with BAPTA to chelate cytosolic calcium did not show a diminished *stimulated* [phospholipase D] . Positive_regulation PLD1 EDN2 8477817 218594 receptors *stimulate* both phospholipase C and [phospholipase D] activities in different cell lines . Positive_regulation PLD1 EDN2 8477817 218636 The *activation* of PLC or [PLD] by in the three cell lines was mediated by the high affinity binding site ( nM range ) and was not significantly affected by either extracellular or intracellular Ca2+ . Positive_regulation PLD1 EDN2 8717070 378884 4. *Activation* by of phosphatidylcholine-specific [phospholipase D] is under the dual regulation of protein kinase C and [Ca2+ ] i , with protein kinase C being the major regulator and [Ca2+ ] i playing a secondary , modulatory role . Positive_regulation PLD1 EPHB2 17030901 1630644 We report here , for the first time in HSC , that extracellular nucleotides stimulate [PLD] activity and a sustained *activation* of . Positive_regulation PLD1 F2R 11991733 938536 Here , we characterized [PLD] *activation* in neonatal rat cardiomyocytes by the PLC-stimulatory thrombin receptor , in comparison to the endothelin-1 receptor ET ( A ) R , which induces PLD stimulation by activation of protein kinase C (PKC) delta and epsilon . Positive_regulation PLD1 F2R 11991733 938542 Similar to ET ( A ) R , activation of *induced* [PLD] stimulation , which , however , was insensitive to PKC inhibition . Positive_regulation PLD1 F2R 11991733 938548 Furthermore , in contrast to ET ( A ) R , [PLD] *stimulation* by was suppressed by overexpression of regulators of G protein signaling specific for G ( 12 ) -type G proteins and treatment with brefeldin A , an inhibitor of guanine nucleotide exchange factors for ADP-ribosylation factor (ARF) GTPases . Positive_regulation PLD1 F2R 11991733 938554 We conclude that , in contrast to ET ( A ) R-PLD coupling , *induced* cardiomyocyte [PLD] stimulation is PKC independent and mediated by G ( 12 ) -type G proteins and ARF GTPases , while Rho and tyrosine kinases regulate PLD stimulation by either receptor , apparently by controlling the cellular level of PIP ( 2 ) , a common regulator of PLD activity . Positive_regulation PLD1 FAS 10395739 627546 *mediated* activation of [phospholipase D] is coupled to the stimulation of phosphatidylcholine-specific phospholipase C in A20 cells . Positive_regulation PLD1 FAS 10395739 627558 cross linking *resulted* in a both dose- and time dependent increases in [phospholipase D] activity . Positive_regulation PLD1 FAS 10395739 627564 Pretreatment of D609 also effectively inhibited the translocation of protein kinase C betaI and betaII from the cytosol to the membrane and the activation of [phospholipase D] *induced* by cross linking , suggesting that 1 , 2-diacylglycerol released from the cellular phosphatidylcholine pool through phosphatidylcholine-specific phospholipase C plays a major role in protein kinase C/phospholipase D activation . Positive_regulation PLD1 FAS 10395739 627570 Therefore , these results suggest that mediated [phospholipase D] *activation* may be a consequence of primary stimulation of phosphatidylcholine-specific phospholipase C and that phospholipase D may play a role in Fas cross linking signaling downstream from phosphatidylcholine-specific phospholipase C . Positive_regulation PLD1 FAS 10799296 691062 We have previously reported that cross linking *resulted* in an increase in [phospholipase D] activity in A20 murine cells ( J.-S . Positive_regulation PLD1 FAS 10799296 691068 These data suggest that Ras GTPase is essential in transmitting [phospholipase D] activation signal *induced* by cross linking and is located at phosphatidylcholine-specific phospholipase C upstream in Fas signaling cascades . Positive_regulation PLD1 FAS 11007187 735367 We have previously reported that cross linking *resulted* in the activation of phosphatidylcholine-specific phospholipase C ( PC-PLC ) and the subsequent activation of protein kinase C ( PKC ) and [phospholipase D (PLD)] in A20 cells . Positive_regulation PLD1 FAS 11007187 735399 In an attempt to correlate the existence of PC-PLC activity and *activation* of [PLD] by activation among various Fas expressing murine cell lines , we have investigated the effect of anti-Fas monoclonal antibody on PC-PLC and PLD activities in A20 , P388D1 and YAC-1 cell lines . Positive_regulation PLD1 FAS 11007187 735413 These findings suggest that the activation of PC-PLC is a necessary requirement for the *activation* of [PLD] by cross linking and cell lines devoid of functional PC-PLC activity could exhibit enhanced PLD activity by exogenous addition of PC-PLC . Positive_regulation PLD1 FAS 11152958 759026 When phosphatidylcholine-specific phospholipase C ( PC-PLC ) was inhibited by D609 , the *induced* changes in [PLD] activity , DAG content , and PKC translocation were inhibited . Positive_regulation PLD1 FAS 11152958 759032 In contrast , D609 had no effect on Fas induced alterations in sphingolipid metabolism , suggesting that changes in ceramide content do not account for *induced* [PLD] activation . Positive_regulation PLD1 FAS 11152958 759038 Furthermore , C6-ceramide had no effect on *induced* [PLD] activation and PKC translocation . Positive_regulation PLD1 FAS 11795496 892360 D609-sensitive tyrosine phosphorylation is involved in mediated [phospholipase D] *activation* . Positive_regulation PLD1 FAS 11795496 892366 Both and PMA can *activate* [phospholipase D] via activation of protein kinase Cbeta in A20 cells . Positive_regulation PLD1 FAS 11795496 892372 [Phospholipase D] activity was increased 4 fold in the *presence* of and 2.5 fold in the presence of PMA . Positive_regulation PLD1 FAS 11795496 892378 The possible involvement of tyrosine phosphorylation in *induced* activation of [phospholipase D] was investigated . Positive_regulation PLD1 FAS 11795496 892384 A tyrosine kinase inhibitor , genistein , can partially inhibit *induced* [phospholipase D] activation . Positive_regulation PLD1 FAS 11795496 892391 These results strongly indicate that tyrosine phosphorylation may in part account for the increase in phospholipase D activity by Fas cross linking and D609 can block not only PC-PLC activity but also tyrosine phosphorylation involved in induced [phospholipase D] *activation* . Positive_regulation PLD1 FAS 12216112 986272 In contrast , cross linking *stimulated* the activity of [PLD] , PC-PLC , and SMase , translocation of PKC , and protein phosphorylation in Fas-resistant clone # 11 , similar to that of wild type cells . Positive_regulation PLD1 GPR115 11102529 756250 Dual requirement for rho and protein kinase C in direct *activation* of [phospholipase D1] through signaling . Positive_regulation PLD1 GPR115 14501041 1183587 Measurement of *stimulated* [phospholipase D] activity in intact cells . Positive_regulation PLD1 GPR132 11102529 756239 Dual requirement for rho and protein kinase C in direct *activation* of [phospholipase D1] through signaling . Positive_regulation PLD1 GPR132 14501041 1183576 Measurement of *stimulated* [phospholipase D] activity in intact cells . Positive_regulation PLD1 GPR87 11102529 756319 Dual requirement for rho and protein kinase C in direct *activation* of [phospholipase D1] through signaling . Positive_regulation PLD1 GPR87 14501041 1183656 Measurement of *stimulated* [phospholipase D] activity in intact cells . Positive_regulation PLD1 IL1B 10525660 654134 *increased* the expression of adenine nucleotide translocator-1 , [phospholipase D-1] and cytokine induced neutrophil chemoattractant-1 and decreased expression of the protein tyrosine phosphatase-like protein IA-2 . Positive_regulation PLD1 IL1B 10919268 717202 *regulates* [phospholipase D-1] expression in rat pancreatic beta-cells . Positive_regulation PLD1 IL1B 10919268 717205 *induced* an early ( 2-6 h ) and sustained ( 16-24 h ) increase in [PLD1a] mRNA expression in insulin producing RINm5F cells . Positive_regulation PLD1 IL1B 10919268 717207 In conclusion , we have shown that the cytokine *regulates* [PLD1] expression in primary and clonal beta-cells . Positive_regulation PLD1 IL1B 11854442 913964 The results of this study indicate that in human amnion cells , might *activate* [PLD] through an upstream protein kinase C to elicit p38 and finally induce COX-2 expression . Positive_regulation PLD1 IL1B 1333514 204407 *stimulated* protein kinase C , [phospholipase D] , and adenylyl cyclase activities ( 0 to 4 hours ) were unchanged from controls . Positive_regulation PLD1 ITGB2 17346796 1727094 Stable adhesion and migration of human neutrophils requires [phospholipase D-mediated] *activation* of the integrin . Positive_regulation PLD1 ITGB2 8872506 389678 bound to protein A-positive Staphylococcus aureus bacteria *induced* a significant [PLD] activation . Positive_regulation PLD1 MAP2K6 11278912 811571 [PLD] activation by AA and HETEs was *reduced* by inhibitors of Ras farnesyltransferase ( farnesyl protein transferase III and BMS-191563 ) and ( U0126 and PD98059 ) . Positive_regulation PLD1 MAP2K6 12929934 1132256 PTH activated p42/p44 MAP kinase , and the effects of PTH , PDBu , and ionomycin on [PLD] , but not on calcium influx , were *prevented* by the inhibitors PD98059 and U0126 . Positive_regulation PLD1 S1PR3 12385647 1034884 We previously demonstrated that sphingosine 1-phosphate (S1P) induced [PLD] *activation* via the G-protein coupled receptor endothelial differentiation gene (EDG) <3/S1P(3)> was involved in S1P induced stimulation of PI 3-kinase and Akt . Positive_regulation PLD1 SNCAIP 12560086 1052751 *activated* [phospholipase D (PLD)] through a pertussis toxin-sensitive mechanism , also involving extracellular Ca2+ and PKC . Positive_regulation PLD1 SNCAIP 8049083 267423 Among the various sphingoid compounds , in addition to sphingosine , only *activated* the endothelial cell [PLD] . Positive_regulation PLD1 SPHK1 15109308 1272944 activity is *required* for sphingosine mediated [phospholipase D] activation in C2C12 myoblasts . Positive_regulation PLD1 SPHK1 9545263 498471 We show here that , in a human monocytic cell line primed with interferon-gamma , FcgammaRI mobilizes intracellular calcium stores using a novel pathway that involves tyrosine kinase coupling to [phospholipase D] and resultant downstream *activation* of . Positive_regulation PLD1 TNF 8444187 213648 *induced* [phospholipase D] activity was observed 1 h before the onset of cell killing and gradually increased thereafter . Positive_regulation PLD1 TNF 8444187 213654 Subclones selected for resistance to TNF cytotoxicity did not show [phospholipase D] activation in *response* to . Positive_regulation PLD1 TNF 8444187 213672 In contrast , when these subclones were treated with TNF in the presence of actinomycin D , TNF cytotoxicity as well as *induced* [phospholipase D] activity could be restored . Positive_regulation PLD1 TNF 8444187 213684 TNF cytotoxicity and *induced* [phospholipase D] activity were equally modulated by various drugs known to interfere with different steps in the TNF signaling pathway . Positive_regulation PLD1 TNF 8444187 213690 Prelabeling of cells with [ 14C ] lysophosphatidylcholine indicated phosphatidylcholine as one of the substrates for *activated* [phospholipase D] . Positive_regulation PLD1 TNF 9831076 551406 Moreover , a comparative study using TNF and anti-Fas antibodies as cell death stimuli showed that [PLD] and cPLA2 are specifically *activated* by . Positive_regulation PLD1 TNF 9873818 557021 Both and anti-Fas/Apo1 monoclonal antibody *increased* [PLD] activity in a dose dependent manner up to 200 U/ml and 200 ng/ml , respectively . Positive_regulation PLD2 ANGPT1 12890486 1117394 Interestingly , *increased* [PLD] activities in a dose- and time dependent manner . Positive_regulation PLD2 EDN2 1537886 180646 Phorbol esters and synthetic diglycerides mimicked the effects of endothelin to stimulate phospholipase D and inhibitors of protein kinase C significantly reduced *stimulated* [phospholipase D] . Positive_regulation PLD2 EDN2 1537886 180664 The calcium ionophore , ionomycin , did not stimulate phospholipase D and mesangial cells pretreated with BAPTA to chelate cytosolic calcium did not show a diminished *stimulated* [phospholipase D] . Positive_regulation PLD2 EDN2 8477817 218597 receptors *stimulate* both phospholipase C and [phospholipase D] activities in different cell lines . Positive_regulation PLD2 EDN2 8477817 218639 The *activation* of PLC or [PLD] by in the three cell lines was mediated by the high affinity binding site ( nM range ) and was not significantly affected by either extracellular or intracellular Ca2+ . Positive_regulation PLD2 EDN2 8717070 378887 4. *Activation* by of phosphatidylcholine-specific [phospholipase D] is under the dual regulation of protein kinase C and [Ca2+ ] i , with protein kinase C being the major regulator and [Ca2+ ] i playing a secondary , modulatory role . Positive_regulation PLD2 EPHB2 17030901 1630645 We report here , for the first time in HSC , that extracellular nucleotides stimulate [PLD] activity and a sustained *activation* of . Positive_regulation PLD2 F2R 11991733 938537 Here , we characterized [PLD] *activation* in neonatal rat cardiomyocytes by the PLC-stimulatory thrombin receptor , in comparison to the endothelin-1 receptor ET ( A ) R , which induces PLD stimulation by activation of protein kinase C (PKC) delta and epsilon . Positive_regulation PLD2 F2R 11991733 938543 Similar to ET ( A ) R , activation of *induced* [PLD] stimulation , which , however , was insensitive to PKC inhibition . Positive_regulation PLD2 F2R 11991733 938549 Furthermore , in contrast to ET ( A ) R , [PLD] *stimulation* by was suppressed by overexpression of regulators of G protein signaling specific for G ( 12 ) -type G proteins and treatment with brefeldin A , an inhibitor of guanine nucleotide exchange factors for ADP-ribosylation factor (ARF) GTPases . Positive_regulation PLD2 F2R 11991733 938555 We conclude that , in contrast to ET ( A ) R-PLD coupling , *induced* cardiomyocyte [PLD] stimulation is PKC independent and mediated by G ( 12 ) -type G proteins and ARF GTPases , while Rho and tyrosine kinases regulate PLD stimulation by either receptor , apparently by controlling the cellular level of PIP ( 2 ) , a common regulator of PLD activity . Positive_regulation PLD2 FAS 10395739 627547 mediated *activation* of [phospholipase D] is coupled to the stimulation of phosphatidylcholine-specific phospholipase C in A20 cells . Positive_regulation PLD2 FAS 10395739 627559 cross linking *resulted* in a both dose- and time dependent increases in [phospholipase D] activity . Positive_regulation PLD2 FAS 10395739 627565 Pretreatment of D609 also effectively inhibited the translocation of protein kinase C betaI and betaII from the cytosol to the membrane and the activation of [phospholipase D] *induced* by cross linking , suggesting that 1 , 2-diacylglycerol released from the cellular phosphatidylcholine pool through phosphatidylcholine-specific phospholipase C plays a major role in protein kinase C/phospholipase D activation . Positive_regulation PLD2 FAS 10395739 627571 Therefore , these results suggest that mediated [phospholipase D] *activation* may be a consequence of primary stimulation of phosphatidylcholine-specific phospholipase C and that phospholipase D may play a role in Fas cross linking signaling downstream from phosphatidylcholine-specific phospholipase C . Positive_regulation PLD2 FAS 10799296 691063 We have previously reported that cross linking *resulted* in an increase in [phospholipase D] activity in A20 murine cells ( J.-S . Positive_regulation PLD2 FAS 10799296 691069 These data suggest that Ras GTPase is essential in transmitting [phospholipase D] activation signal *induced* by cross linking and is located at phosphatidylcholine-specific phospholipase C upstream in Fas signaling cascades . Positive_regulation PLD2 FAS 11007187 735369 We have previously reported that cross linking *resulted* in the activation of phosphatidylcholine-specific phospholipase C ( PC-PLC ) and the subsequent activation of protein kinase C ( PKC ) and [phospholipase D (PLD)] in A20 cells . Positive_regulation PLD2 FAS 11007187 735401 In an attempt to correlate the existence of PC-PLC activity and *activation* of [PLD] by activation among various Fas expressing murine cell lines , we have investigated the effect of anti-Fas monoclonal antibody on PC-PLC and PLD activities in A20 , P388D1 and YAC-1 cell lines . Positive_regulation PLD2 FAS 11007187 735414 These findings suggest that the activation of PC-PLC is a necessary requirement for the *activation* of [PLD] by cross linking and cell lines devoid of functional PC-PLC activity could exhibit enhanced PLD activity by exogenous addition of PC-PLC . Positive_regulation PLD2 FAS 11152958 759027 When phosphatidylcholine-specific phospholipase C ( PC-PLC ) was inhibited by D609 , the *induced* changes in [PLD] activity , DAG content , and PKC translocation were inhibited . Positive_regulation PLD2 FAS 11152958 759033 In contrast , D609 had no effect on Fas induced alterations in sphingolipid metabolism , suggesting that changes in ceramide content do not account for induced [PLD] *activation* . Positive_regulation PLD2 FAS 11152958 759039 Furthermore , C6-ceramide had no effect on induced [PLD] *activation* and PKC translocation . Positive_regulation PLD2 FAS 11795496 892361 D609-sensitive tyrosine phosphorylation is involved in mediated [phospholipase D] *activation* . Positive_regulation PLD2 FAS 11795496 892367 Both and PMA can *activate* [phospholipase D] via activation of protein kinase Cbeta in A20 cells . Positive_regulation PLD2 FAS 11795496 892373 [Phospholipase D] activity was increased 4 fold in the *presence* of and 2.5 fold in the presence of PMA . Positive_regulation PLD2 FAS 11795496 892379 The possible involvement of tyrosine phosphorylation in induced *activation* of [phospholipase D] was investigated . Positive_regulation PLD2 FAS 11795496 892385 A tyrosine kinase inhibitor , genistein , can partially inhibit induced [phospholipase D] *activation* . Positive_regulation PLD2 FAS 11795496 892392 These results strongly indicate that tyrosine phosphorylation may in part account for the increase in phospholipase D activity by Fas cross linking and D609 can block not only PC-PLC activity but also tyrosine phosphorylation involved in *induced* [phospholipase D] activation . Positive_regulation PLD2 FAS 12216112 986273 In contrast , cross linking *stimulated* the activity of [PLD] , PC-PLC , and SMase , translocation of PKC , and protein phosphorylation in Fas-resistant clone # 11 , similar to that of wild type cells . Positive_regulation PLD2 GPR115 14501041 1183680 Measurement of *stimulated* [phospholipase D] activity in intact cells . Positive_regulation PLD2 GPR132 14501041 1183669 Measurement of *stimulated* [phospholipase D] activity in intact cells . Positive_regulation PLD2 GPR87 14501041 1183749 Measurement of *stimulated* [phospholipase D] activity in intact cells . Positive_regulation PLD2 IL1B 11854442 913966 The results of this study indicate that in human amnion cells , might *activate* [PLD] through an upstream protein kinase C to elicit p38 and finally induce COX-2 expression . Positive_regulation PLD2 IL1B 1333514 204408 *stimulated* protein kinase C , [phospholipase D] , and adenylyl cyclase activities ( 0 to 4 hours ) were unchanged from controls . Positive_regulation PLD2 ITGB2 17346796 1727096 Stable adhesion and migration of human neutrophils requires [phospholipase D-mediated] *activation* of the integrin . Positive_regulation PLD2 ITGB2 8872506 389679 bound to protein A-positive Staphylococcus aureus bacteria *induced* a significant [PLD] activation . Positive_regulation PLD2 MAP2K6 11278912 811580 [PLD] activation by AA and HETEs was *reduced* by inhibitors of Ras farnesyltransferase ( farnesyl protein transferase III and BMS-191563 ) and ( U0126 and PD98059 ) . Positive_regulation PLD2 MAP2K6 12929934 1132263 PTH activated p42/p44 MAP kinase , and the effects of PTH , PDBu , and ionomycin on [PLD] , but not on calcium influx , were *prevented* by the inhibitors PD98059 and U0126 . Positive_regulation PLD2 MAP2K6 15226317 1289304 Furthermore , [PLD2] was *activated* by , whereas NGF stimulated PLD2 activation and hypertrophic neurite extension were blocked by an MEK-specific inhibitor . Positive_regulation PLD2 S1PR3 12385647 1034886 We previously demonstrated that sphingosine 1-phosphate (S1P) induced [PLD] *activation* via the G-protein coupled receptor was involved in S1P induced stimulation of PI 3-kinase and Akt . Positive_regulation PLD2 SNCAIP 12560086 1052752 *activated* [phospholipase D (PLD)] through a pertussis toxin-sensitive mechanism , also involving extracellular Ca2+ and PKC . Positive_regulation PLD2 SNCAIP 8049083 267424 Among the various sphingoid compounds , in addition to sphingosine , only *activated* the endothelial cell [PLD] . Positive_regulation PLD2 SPHK1 15109308 1272946 activity is *required* for sphingosine mediated [phospholipase D] activation in C2C12 myoblasts . Positive_regulation PLD2 SPHK1 9545263 498473 We show here that , in a human monocytic cell line primed with interferon-gamma , FcgammaRI mobilizes intracellular calcium stores using a novel pathway that involves tyrosine kinase coupling to [phospholipase D] and resultant downstream *activation* of . Positive_regulation PLD2 TNF 8444187 213649 *induced* [phospholipase D] activity was observed 1 h before the onset of cell killing and gradually increased thereafter . Positive_regulation PLD2 TNF 8444187 213655 Subclones selected for resistance to TNF cytotoxicity did not show [phospholipase D] activation in *response* to . Positive_regulation PLD2 TNF 8444187 213673 In contrast , when these subclones were treated with TNF in the presence of actinomycin D , TNF cytotoxicity as well as *induced* [phospholipase D] activity could be restored . Positive_regulation PLD2 TNF 8444187 213685 TNF cytotoxicity and *induced* [phospholipase D] activity were equally modulated by various drugs known to interfere with different steps in the TNF signaling pathway . Positive_regulation PLD2 TNF 8444187 213691 Prelabeling of cells with [ 14C ] lysophosphatidylcholine indicated phosphatidylcholine as one of the substrates for *activated* [phospholipase D] . Positive_regulation PLD2 TNF 9831076 551407 Moreover , a comparative study using TNF and anti-Fas antibodies as cell death stimuli showed that [PLD] and cPLA2 are specifically *activated* by . Positive_regulation PLD2 TNF 9873818 557022 Both and anti-Fas/Apo1 monoclonal antibody *increased* [PLD] activity in a dose dependent manner up to 200 U/ml and 200 ng/ml , respectively . Positive_regulation PLD3 ANGPT1 12890486 1117389 Interestingly , *increased* [PLD] activities in a dose- and time dependent manner . Positive_regulation PLD3 EDN2 1537886 180631 Phorbol esters and synthetic diglycerides mimicked the effects of endothelin to stimulate phospholipase D and inhibitors of protein kinase C significantly reduced *stimulated* [phospholipase D] . Positive_regulation PLD3 EDN2 1537886 180649 The calcium ionophore , ionomycin , did not stimulate phospholipase D and mesangial cells pretreated with BAPTA to chelate cytosolic calcium did not show a diminished *stimulated* [phospholipase D] . Positive_regulation PLD3 EDN2 8477817 218582 receptors *stimulate* both phospholipase C and [phospholipase D] activities in different cell lines . Positive_regulation PLD3 EDN2 8477817 218600 The *activation* of PLC or [PLD] by in the three cell lines was mediated by the high affinity binding site ( nM range ) and was not significantly affected by either extracellular or intracellular Ca2+ . Positive_regulation PLD3 EDN2 8717070 378854 4. *Activation* by of phosphatidylcholine-specific [phospholipase D] is under the dual regulation of protein kinase C and [Ca2+ ] i , with protein kinase C being the major regulator and [Ca2+ ] i playing a secondary , modulatory role . Positive_regulation PLD3 EPHB2 17030901 1630640 We report here , for the first time in HSC , that extracellular nucleotides stimulate [PLD] activity and a sustained *activation* of . Positive_regulation PLD3 F2R 11991733 938532 Here , we characterized [PLD] *activation* in neonatal rat cardiomyocytes by the PLC-stimulatory thrombin receptor , in comparison to the endothelin-1 receptor ET ( A ) R , which induces PLD stimulation by activation of protein kinase C (PKC) delta and epsilon . Positive_regulation PLD3 F2R 11991733 938538 Similar to ET ( A ) R , activation of *induced* [PLD] stimulation , which , however , was insensitive to PKC inhibition . Positive_regulation PLD3 F2R 11991733 938544 Furthermore , in contrast to ET ( A ) R , [PLD] *stimulation* by was suppressed by overexpression of regulators of G protein signaling specific for G ( 12 ) -type G proteins and treatment with brefeldin A , an inhibitor of guanine nucleotide exchange factors for ADP-ribosylation factor (ARF) GTPases . Positive_regulation PLD3 F2R 11991733 938550 We conclude that , in contrast to ET ( A ) R-PLD coupling , *induced* cardiomyocyte [PLD] stimulation is PKC independent and mediated by G ( 12 ) -type G proteins and ARF GTPases , while Rho and tyrosine kinases regulate PLD stimulation by either receptor , apparently by controlling the cellular level of PIP ( 2 ) , a common regulator of PLD activity . Positive_regulation PLD3 FAS 10395739 627542 *mediated* activation of [phospholipase D] is coupled to the stimulation of phosphatidylcholine-specific phospholipase C in A20 cells . Positive_regulation PLD3 FAS 10395739 627554 cross linking *resulted* in a both dose- and time dependent increases in [phospholipase D] activity . Positive_regulation PLD3 FAS 10395739 627560 Pretreatment of D609 also effectively inhibited the translocation of protein kinase C betaI and betaII from the cytosol to the membrane and the activation of [phospholipase D] *induced* by cross linking , suggesting that 1 , 2-diacylglycerol released from the cellular phosphatidylcholine pool through phosphatidylcholine-specific phospholipase C plays a major role in protein kinase C/phospholipase D activation . Positive_regulation PLD3 FAS 10395739 627566 Therefore , these results suggest that mediated [phospholipase D] *activation* may be a consequence of primary stimulation of phosphatidylcholine-specific phospholipase C and that phospholipase D may play a role in Fas cross linking signaling downstream from phosphatidylcholine-specific phospholipase C . Positive_regulation PLD3 FAS 10799296 691058 We have previously reported that cross linking *resulted* in an increase in [phospholipase D] activity in A20 murine cells ( J.-S . Positive_regulation PLD3 FAS 10799296 691064 These data suggest that Ras GTPase is essential in transmitting [phospholipase D] activation signal *induced* by cross linking and is located at phosphatidylcholine-specific phospholipase C upstream in Fas signaling cascades . Positive_regulation PLD3 FAS 11007187 735352 We have previously reported that cross linking *resulted* in the activation of phosphatidylcholine-specific phospholipase C ( PC-PLC ) and the subsequent activation of protein kinase C ( PKC ) and [phospholipase D (PLD)] in A20 cells . Positive_regulation PLD3 FAS 11007187 735384 In an attempt to correlate the existence of PC-PLC activity and *activation* of [PLD] by activation among various Fas expressing murine cell lines , we have investigated the effect of anti-Fas monoclonal antibody on PC-PLC and PLD activities in A20 , P388D1 and YAC-1 cell lines . Positive_regulation PLD3 FAS 11007187 735409 These findings suggest that the activation of PC-PLC is a necessary requirement for the *activation* of [PLD] by cross linking and cell lines devoid of functional PC-PLC activity could exhibit enhanced PLD activity by exogenous addition of PC-PLC . Positive_regulation PLD3 FAS 11152958 759022 When phosphatidylcholine-specific phospholipase C ( PC-PLC ) was inhibited by D609 , the *induced* changes in [PLD] activity , DAG content , and PKC translocation were inhibited . Positive_regulation PLD3 FAS 11152958 759028 In contrast , D609 had no effect on Fas induced alterations in sphingolipid metabolism , suggesting that changes in ceramide content do not account for *induced* [PLD] activation . Positive_regulation PLD3 FAS 11152958 759034 Furthermore , C6-ceramide had no effect on *induced* [PLD] activation and PKC translocation . Positive_regulation PLD3 FAS 11795496 892356 D609-sensitive tyrosine phosphorylation is involved in mediated [phospholipase D] *activation* . Positive_regulation PLD3 FAS 11795496 892362 Both and PMA can *activate* [phospholipase D] via activation of protein kinase Cbeta in A20 cells . Positive_regulation PLD3 FAS 11795496 892368 [Phospholipase D] activity was increased 4 fold in the *presence* of and 2.5 fold in the presence of PMA . Positive_regulation PLD3 FAS 11795496 892374 The possible involvement of tyrosine phosphorylation in *induced* activation of [phospholipase D] was investigated . Positive_regulation PLD3 FAS 11795496 892380 A tyrosine kinase inhibitor , genistein , can partially inhibit *induced* [phospholipase D] activation . Positive_regulation PLD3 FAS 11795496 892387 These results strongly indicate that tyrosine phosphorylation may in part account for the increase in phospholipase D activity by Fas cross linking and D609 can block not only PC-PLC activity but also tyrosine phosphorylation involved in *induced* [phospholipase D] activation . Positive_regulation PLD3 FAS 12216112 986267 In contrast , cross linking *stimulated* the activity of [PLD] , PC-PLC , and SMase , translocation of PKC , and protein phosphorylation in Fas-resistant clone # 11 , similar to that of wild type cells . Positive_regulation PLD3 GPR115 14501041 1183215 Measurement of *stimulated* [phospholipase D] activity in intact cells . Positive_regulation PLD3 GPR132 14501041 1183204 Measurement of *stimulated* [phospholipase D] activity in intact cells . Positive_regulation PLD3 GPR87 14501041 1183284 Measurement of *stimulated* [phospholipase D] activity in intact cells . Positive_regulation PLD3 IL1B 11854442 913955 The results of this study indicate that in human amnion cells , might *activate* [PLD] through an upstream protein kinase C to elicit p38 and finally induce COX-2 expression . Positive_regulation PLD3 IL1B 1333514 204403 *stimulated* protein kinase C , [phospholipase D] , and adenylyl cyclase activities ( 0 to 4 hours ) were unchanged from controls . Positive_regulation PLD3 ITGB2 17346796 1727086 Stable adhesion and migration of human neutrophils requires [phospholipase D-mediated] *activation* of the integrin . Positive_regulation PLD3 ITGB2 8872506 389668 bound to protein A-positive Staphylococcus aureus bacteria *induced* a significant [PLD] activation . Positive_regulation PLD3 MAP2K6 11278912 811535 [PLD] activation by AA and HETEs was *reduced* by inhibitors of Ras farnesyltransferase ( farnesyl protein transferase III and BMS-191563 ) and ( U0126 and PD98059 ) . Positive_regulation PLD3 MAP2K6 12929934 1132228 PTH activated p42/p44 MAP kinase , and the effects of PTH , PDBu , and ionomycin on [PLD] , but not on calcium influx , were *prevented* by the inhibitors PD98059 and U0126 . Positive_regulation PLD3 S1PR3 12385647 1034844 We previously demonstrated that sphingosine 1-phosphate (S1P) induced [PLD] *activation* via the G-protein coupled receptor was involved in S1P induced stimulation of PI 3-kinase and Akt . Positive_regulation PLD3 SNCAIP 12560086 1052747 *activated* [phospholipase D (PLD)] through a pertussis toxin-sensitive mechanism , also involving extracellular Ca2+ and PKC . Positive_regulation PLD3 SNCAIP 8049083 267419 Among the various sphingoid compounds , in addition to sphingosine , only *activated* the endothelial cell [PLD] . Positive_regulation PLD3 SPHK1 15109308 1272936 activity is *required* for sphingosine mediated [phospholipase D] activation in C2C12 myoblasts . Positive_regulation PLD3 SPHK1 9545263 498463 We show here that , in a human monocytic cell line primed with interferon-gamma , FcgammaRI mobilizes intracellular calcium stores using a novel pathway that involves tyrosine kinase coupling to [phospholipase D] and resultant downstream *activation* of . Positive_regulation PLD3 TNF 8444187 213644 *induced* [phospholipase D] activity was observed 1 h before the onset of cell killing and gradually increased thereafter . Positive_regulation PLD3 TNF 8444187 213650 Subclones selected for resistance to TNF cytotoxicity did not show [phospholipase D] activation in *response* to . Positive_regulation PLD3 TNF 8444187 213668 In contrast , when these subclones were treated with TNF in the presence of actinomycin D , TNF cytotoxicity as well as *induced* [phospholipase D] activity could be restored . Positive_regulation PLD3 TNF 8444187 213680 TNF cytotoxicity and *induced* [phospholipase D] activity were equally modulated by various drugs known to interfere with different steps in the TNF signaling pathway . Positive_regulation PLD3 TNF 8444187 213686 Prelabeling of cells with [ 14C ] lysophosphatidylcholine indicated phosphatidylcholine as one of the substrates for *activated* [phospholipase D] . Positive_regulation PLD3 TNF 9831076 551401 Moreover , a comparative study using TNF and anti-Fas antibodies as cell death stimuli showed that [PLD] and cPLA2 are specifically *activated* by . Positive_regulation PLD3 TNF 9873818 557017 Both and anti-Fas/Apo1 monoclonal antibody *increased* [PLD] activity in a dose dependent manner up to 200 U/ml and 200 ng/ml , respectively . Positive_regulation PLD4 ANGPT1 12890486 1117390 Interestingly , *increased* [PLD] activities in a dose- and time dependent manner . Positive_regulation PLD4 EDN2 1537886 180634 Phorbol esters and synthetic diglycerides mimicked the effects of endothelin to stimulate phospholipase D and inhibitors of protein kinase C significantly reduced *stimulated* [phospholipase D] . Positive_regulation PLD4 EDN2 1537886 180652 The calcium ionophore , ionomycin , did not stimulate phospholipase D and mesangial cells pretreated with BAPTA to chelate cytosolic calcium did not show a diminished *stimulated* [phospholipase D] . Positive_regulation PLD4 EDN2 8477817 218585 receptors *stimulate* both phospholipase C and [phospholipase D] activities in different cell lines . Positive_regulation PLD4 EDN2 8477817 218603 The *activation* of PLC or [PLD] by in the three cell lines was mediated by the high affinity binding site ( nM range ) and was not significantly affected by either extracellular or intracellular Ca2+ . Positive_regulation PLD4 EDN2 8717070 378857 4. *Activation* by of phosphatidylcholine-specific [phospholipase D] is under the dual regulation of protein kinase C and [Ca2+ ] i , with protein kinase C being the major regulator and [Ca2+ ] i playing a secondary , modulatory role . Positive_regulation PLD4 EPHB2 17030901 1630641 We report here , for the first time in HSC , that extracellular nucleotides stimulate [PLD] activity and a sustained *activation* of . Positive_regulation PLD4 F2R 11991733 938533 Here , we characterized [PLD] *activation* in neonatal rat cardiomyocytes by the PLC-stimulatory thrombin receptor , in comparison to the endothelin-1 receptor ET ( A ) R , which induces PLD stimulation by activation of protein kinase C (PKC) delta and epsilon . Positive_regulation PLD4 F2R 11991733 938539 Similar to ET ( A ) R , activation of *induced* [PLD] stimulation , which , however , was insensitive to PKC inhibition . Positive_regulation PLD4 F2R 11991733 938545 Furthermore , in contrast to ET ( A ) R , [PLD] *stimulation* by was suppressed by overexpression of regulators of G protein signaling specific for G ( 12 ) -type G proteins and treatment with brefeldin A , an inhibitor of guanine nucleotide exchange factors for ADP-ribosylation factor (ARF) GTPases . Positive_regulation PLD4 F2R 11991733 938551 We conclude that , in contrast to ET ( A ) R-PLD coupling , *induced* cardiomyocyte [PLD] stimulation is PKC independent and mediated by G ( 12 ) -type G proteins and ARF GTPases , while Rho and tyrosine kinases regulate PLD stimulation by either receptor , apparently by controlling the cellular level of PIP ( 2 ) , a common regulator of PLD activity . Positive_regulation PLD4 FAS 10395739 627543 mediated *activation* of [phospholipase D] is coupled to the stimulation of phosphatidylcholine-specific phospholipase C in A20 cells . Positive_regulation PLD4 FAS 10395739 627555 cross linking *resulted* in a both dose- and time dependent increases in [phospholipase D] activity . Positive_regulation PLD4 FAS 10395739 627561 Pretreatment of D609 also effectively inhibited the translocation of protein kinase C betaI and betaII from the cytosol to the membrane and the activation of [phospholipase D] *induced* by cross linking , suggesting that 1 , 2-diacylglycerol released from the cellular phosphatidylcholine pool through phosphatidylcholine-specific phospholipase C plays a major role in protein kinase C/phospholipase D activation . Positive_regulation PLD4 FAS 10395739 627567 Therefore , these results suggest that mediated [phospholipase D] *activation* may be a consequence of primary stimulation of phosphatidylcholine-specific phospholipase C and that phospholipase D may play a role in Fas cross linking signaling downstream from phosphatidylcholine-specific phospholipase C . Positive_regulation PLD4 FAS 10799296 691059 We have previously reported that cross linking *resulted* in an increase in [phospholipase D] activity in A20 murine cells ( J.-S . Positive_regulation PLD4 FAS 10799296 691065 These data suggest that Ras GTPase is essential in transmitting [phospholipase D] activation signal *induced* by cross linking and is located at phosphatidylcholine-specific phospholipase C upstream in Fas signaling cascades . Positive_regulation PLD4 FAS 11007187 735354 We have previously reported that cross linking *resulted* in the activation of phosphatidylcholine-specific phospholipase C ( PC-PLC ) and the subsequent activation of protein kinase C ( PKC ) and [phospholipase D (PLD)] in A20 cells . Positive_regulation PLD4 FAS 11007187 735386 In an attempt to correlate the existence of PC-PLC activity and *activation* of [PLD] by activation among various Fas expressing murine cell lines , we have investigated the effect of anti-Fas monoclonal antibody on PC-PLC and PLD activities in A20 , P388D1 and YAC-1 cell lines . Positive_regulation PLD4 FAS 11007187 735410 These findings suggest that the activation of PC-PLC is a necessary requirement for the *activation* of [PLD] by cross linking and cell lines devoid of functional PC-PLC activity could exhibit enhanced PLD activity by exogenous addition of PC-PLC . Positive_regulation PLD4 FAS 11152958 759023 When phosphatidylcholine-specific phospholipase C ( PC-PLC ) was inhibited by D609 , the *induced* changes in [PLD] activity , DAG content , and PKC translocation were inhibited . Positive_regulation PLD4 FAS 11152958 759029 In contrast , D609 had no effect on Fas induced alterations in sphingolipid metabolism , suggesting that changes in ceramide content do not account for induced [PLD] *activation* . Positive_regulation PLD4 FAS 11152958 759035 Furthermore , C6-ceramide had no effect on induced [PLD] *activation* and PKC translocation . Positive_regulation PLD4 FAS 11795496 892357 D609-sensitive tyrosine phosphorylation is involved in mediated [phospholipase D] *activation* . Positive_regulation PLD4 FAS 11795496 892363 Both and PMA can *activate* [phospholipase D] via activation of protein kinase Cbeta in A20 cells . Positive_regulation PLD4 FAS 11795496 892369 [Phospholipase D] activity was increased 4 fold in the *presence* of and 2.5 fold in the presence of PMA . Positive_regulation PLD4 FAS 11795496 892375 The possible involvement of tyrosine phosphorylation in induced *activation* of [phospholipase D] was investigated . Positive_regulation PLD4 FAS 11795496 892381 A tyrosine kinase inhibitor , genistein , can partially inhibit induced [phospholipase D] *activation* . Positive_regulation PLD4 FAS 11795496 892388 These results strongly indicate that tyrosine phosphorylation may in part account for the increase in phospholipase D activity by Fas cross linking and D609 can block not only PC-PLC activity but also tyrosine phosphorylation involved in induced [phospholipase D] *activation* . Positive_regulation PLD4 FAS 12216112 986268 In contrast , cross linking *stimulated* the activity of [PLD] , PC-PLC , and SMase , translocation of PKC , and protein phosphorylation in Fas-resistant clone # 11 , similar to that of wild type cells . Positive_regulation PLD4 GPR115 14501041 1183308 Measurement of *stimulated* [phospholipase D] activity in intact cells . Positive_regulation PLD4 GPR132 14501041 1183297 Measurement of *stimulated* [phospholipase D] activity in intact cells . Positive_regulation PLD4 GPR87 14501041 1183377 Measurement of *stimulated* [phospholipase D] activity in intact cells . Positive_regulation PLD4 IL1B 11854442 913957 The results of this study indicate that in human amnion cells , might *activate* [PLD] through an upstream protein kinase C to elicit p38 and finally induce COX-2 expression . Positive_regulation PLD4 IL1B 1333514 204404 *stimulated* protein kinase C , [phospholipase D] , and adenylyl cyclase activities ( 0 to 4 hours ) were unchanged from controls . Positive_regulation PLD4 ITGB2 17346796 1727088 Stable adhesion and migration of human neutrophils requires [phospholipase D-mediated] *activation* of the integrin . Positive_regulation PLD4 ITGB2 8872506 389669 bound to protein A-positive Staphylococcus aureus bacteria *induced* a significant [PLD] activation . Positive_regulation PLD4 MAP2K6 11278912 811544 [PLD] activation by AA and HETEs was *reduced* by inhibitors of Ras farnesyltransferase ( farnesyl protein transferase III and BMS-191563 ) and ( U0126 and PD98059 ) . Positive_regulation PLD4 MAP2K6 12929934 1132235 PTH activated p42/p44 MAP kinase , and the effects of PTH , PDBu , and ionomycin on [PLD] , but not on calcium influx , were *prevented* by the inhibitors PD98059 and U0126 . Positive_regulation PLD4 S1PR3 12385647 1034846 We previously demonstrated that sphingosine 1-phosphate (S1P) induced [PLD] *activation* via the G-protein coupled receptor was involved in S1P induced stimulation of PI 3-kinase and Akt . Positive_regulation PLD4 SNCAIP 12560086 1052748 *activated* [phospholipase D (PLD)] through a pertussis toxin-sensitive mechanism , also involving extracellular Ca2+ and PKC . Positive_regulation PLD4 SNCAIP 8049083 267420 Among the various sphingoid compounds , in addition to sphingosine , only *activated* the endothelial cell [PLD] . Positive_regulation PLD4 SPHK1 15109308 1272938 activity is *required* for sphingosine mediated [phospholipase D] activation in C2C12 myoblasts . Positive_regulation PLD4 SPHK1 9545263 498465 We show here that , in a human monocytic cell line primed with interferon-gamma , FcgammaRI mobilizes intracellular calcium stores using a novel pathway that involves tyrosine kinase coupling to [phospholipase D] and resultant downstream *activation* of . Positive_regulation PLD4 TNF 8444187 213645 *induced* [phospholipase D] activity was observed 1 h before the onset of cell killing and gradually increased thereafter . Positive_regulation PLD4 TNF 8444187 213651 Subclones selected for resistance to TNF cytotoxicity did not show [phospholipase D] activation in *response* to . Positive_regulation PLD4 TNF 8444187 213669 In contrast , when these subclones were treated with TNF in the presence of actinomycin D , TNF cytotoxicity as well as *induced* [phospholipase D] activity could be restored . Positive_regulation PLD4 TNF 8444187 213681 TNF cytotoxicity and *induced* [phospholipase D] activity were equally modulated by various drugs known to interfere with different steps in the TNF signaling pathway . Positive_regulation PLD4 TNF 8444187 213687 Prelabeling of cells with [ 14C ] lysophosphatidylcholine indicated phosphatidylcholine as one of the substrates for *activated* [phospholipase D] . Positive_regulation PLD4 TNF 9831076 551402 Moreover , a comparative study using TNF and anti-Fas antibodies as cell death stimuli showed that [PLD] and cPLA2 are specifically *activated* by . Positive_regulation PLD4 TNF 9873818 557018 Both and anti-Fas/Apo1 monoclonal antibody *increased* [PLD] activity in a dose dependent manner up to 200 U/ml and 200 ng/ml , respectively . Positive_regulation PLD5 ANGPT1 12890486 1117391 Interestingly , *increased* [PLD] activities in a dose- and time dependent manner . Positive_regulation PLD5 EDN2 1537886 180637 Phorbol esters and synthetic diglycerides mimicked the effects of endothelin to stimulate phospholipase D and inhibitors of protein kinase C significantly reduced *stimulated* [phospholipase D] . Positive_regulation PLD5 EDN2 1537886 180655 The calcium ionophore , ionomycin , did not stimulate phospholipase D and mesangial cells pretreated with BAPTA to chelate cytosolic calcium did not show a diminished *stimulated* [phospholipase D] . Positive_regulation PLD5 EDN2 8477817 218588 receptors *stimulate* both phospholipase C and [phospholipase D] activities in different cell lines . Positive_regulation PLD5 EDN2 8477817 218606 The *activation* of PLC or [PLD] by in the three cell lines was mediated by the high affinity binding site ( nM range ) and was not significantly affected by either extracellular or intracellular Ca2+ . Positive_regulation PLD5 EDN2 8717070 378860 4. *Activation* by of phosphatidylcholine-specific [phospholipase D] is under the dual regulation of protein kinase C and [Ca2+ ] i , with protein kinase C being the major regulator and [Ca2+ ] i playing a secondary , modulatory role . Positive_regulation PLD5 EPHB2 17030901 1630642 We report here , for the first time in HSC , that extracellular nucleotides stimulate [PLD] activity and a sustained *activation* of . Positive_regulation PLD5 F2R 11991733 938534 Here , we characterized [PLD] *activation* in neonatal rat cardiomyocytes by the PLC-stimulatory thrombin receptor , in comparison to the endothelin-1 receptor ET ( A ) R , which induces PLD stimulation by activation of protein kinase C (PKC) delta and epsilon . Positive_regulation PLD5 F2R 11991733 938540 Similar to ET ( A ) R , activation of *induced* [PLD] stimulation , which , however , was insensitive to PKC inhibition . Positive_regulation PLD5 F2R 11991733 938546 Furthermore , in contrast to ET ( A ) R , [PLD] *stimulation* by was suppressed by overexpression of regulators of G protein signaling specific for G ( 12 ) -type G proteins and treatment with brefeldin A , an inhibitor of guanine nucleotide exchange factors for ADP-ribosylation factor (ARF) GTPases . Positive_regulation PLD5 F2R 11991733 938552 We conclude that , in contrast to ET ( A ) R-PLD coupling , *induced* cardiomyocyte [PLD] stimulation is PKC independent and mediated by G ( 12 ) -type G proteins and ARF GTPases , while Rho and tyrosine kinases regulate PLD stimulation by either receptor , apparently by controlling the cellular level of PIP ( 2 ) , a common regulator of PLD activity . Positive_regulation PLD5 FAS 10395739 627544 *mediated* activation of [phospholipase D] is coupled to the stimulation of phosphatidylcholine-specific phospholipase C in A20 cells . Positive_regulation PLD5 FAS 10395739 627556 cross linking *resulted* in a both dose- and time dependent increases in [phospholipase D] activity . Positive_regulation PLD5 FAS 10395739 627562 Pretreatment of D609 also effectively inhibited the translocation of protein kinase C betaI and betaII from the cytosol to the membrane and the activation of [phospholipase D] *induced* by cross linking , suggesting that 1 , 2-diacylglycerol released from the cellular phosphatidylcholine pool through phosphatidylcholine-specific phospholipase C plays a major role in protein kinase C/phospholipase D activation . Positive_regulation PLD5 FAS 10395739 627568 Therefore , these results suggest that mediated [phospholipase D] *activation* may be a consequence of primary stimulation of phosphatidylcholine-specific phospholipase C and that phospholipase D may play a role in Fas cross linking signaling downstream from phosphatidylcholine-specific phospholipase C . Positive_regulation PLD5 FAS 10799296 691060 We have previously reported that cross linking *resulted* in an increase in [phospholipase D] activity in A20 murine cells ( J.-S . Positive_regulation PLD5 FAS 10799296 691066 These data suggest that Ras GTPase is essential in transmitting [phospholipase D] activation signal *induced* by cross linking and is located at phosphatidylcholine-specific phospholipase C upstream in Fas signaling cascades . Positive_regulation PLD5 FAS 11007187 735356 We have previously reported that cross linking *resulted* in the activation of phosphatidylcholine-specific phospholipase C ( PC-PLC ) and the subsequent activation of protein kinase C ( PKC ) and [phospholipase D (PLD)] in A20 cells . Positive_regulation PLD5 FAS 11007187 735388 In an attempt to correlate the existence of PC-PLC activity and *activation* of [PLD] by activation among various Fas expressing murine cell lines , we have investigated the effect of anti-Fas monoclonal antibody on PC-PLC and PLD activities in A20 , P388D1 and YAC-1 cell lines . Positive_regulation PLD5 FAS 11007187 735411 These findings suggest that the activation of PC-PLC is a necessary requirement for the *activation* of [PLD] by cross linking and cell lines devoid of functional PC-PLC activity could exhibit enhanced PLD activity by exogenous addition of PC-PLC . Positive_regulation PLD5 FAS 11152958 759024 When phosphatidylcholine-specific phospholipase C ( PC-PLC ) was inhibited by D609 , the *induced* changes in [PLD] activity , DAG content , and PKC translocation were inhibited . Positive_regulation PLD5 FAS 11152958 759030 In contrast , D609 had no effect on Fas induced alterations in sphingolipid metabolism , suggesting that changes in ceramide content do not account for *induced* [PLD] activation . Positive_regulation PLD5 FAS 11152958 759036 Furthermore , C6-ceramide had no effect on *induced* [PLD] activation and PKC translocation . Positive_regulation PLD5 FAS 11795496 892358 D609-sensitive tyrosine phosphorylation is involved in mediated [phospholipase D] *activation* . Positive_regulation PLD5 FAS 11795496 892364 Both and PMA can *activate* [phospholipase D] via activation of protein kinase Cbeta in A20 cells . Positive_regulation PLD5 FAS 11795496 892370 [Phospholipase D] activity was increased 4 fold in the *presence* of and 2.5 fold in the presence of PMA . Positive_regulation PLD5 FAS 11795496 892376 The possible involvement of tyrosine phosphorylation in *induced* activation of [phospholipase D] was investigated . Positive_regulation PLD5 FAS 11795496 892382 A tyrosine kinase inhibitor , genistein , can partially inhibit induced [phospholipase D] *activation* . Positive_regulation PLD5 FAS 11795496 892389 These results strongly indicate that tyrosine phosphorylation may in part account for the increase in phospholipase D activity by Fas cross linking and D609 can block not only PC-PLC activity but also tyrosine phosphorylation involved in *induced* [phospholipase D] activation . Positive_regulation PLD5 FAS 12216112 986269 In contrast , cross linking *stimulated* the activity of [PLD] , PC-PLC , and SMase , translocation of PKC , and protein phosphorylation in Fas-resistant clone # 11 , similar to that of wild type cells . Positive_regulation PLD5 GPR115 14501041 1183401 Measurement of *stimulated* [phospholipase D] activity in intact cells . Positive_regulation PLD5 GPR132 14501041 1183390 Measurement of *stimulated* [phospholipase D] activity in intact cells . Positive_regulation PLD5 GPR87 14501041 1183470 Measurement of *stimulated* [phospholipase D] activity in intact cells . Positive_regulation PLD5 IL1B 11854442 913959 The results of this study indicate that in human amnion cells , might *activate* [PLD] through an upstream protein kinase C to elicit p38 and finally induce COX-2 expression . Positive_regulation PLD5 IL1B 1333514 204405 *stimulated* protein kinase C , [phospholipase D] , and adenylyl cyclase activities ( 0 to 4 hours ) were unchanged from controls . Positive_regulation PLD5 ITGB2 17346796 1727090 Stable adhesion and migration of human neutrophils requires [phospholipase D-mediated] *activation* of the integrin . Positive_regulation PLD5 ITGB2 8872506 389670 bound to protein A-positive Staphylococcus aureus bacteria *induced* a significant [PLD] activation . Positive_regulation PLD5 MAP2K6 11278912 811553 [PLD] activation by AA and HETEs was *reduced* by inhibitors of Ras farnesyltransferase ( farnesyl protein transferase III and BMS-191563 ) and ( U0126 and PD98059 ) . Positive_regulation PLD5 MAP2K6 12929934 1132242 PTH activated p42/p44 MAP kinase , and the effects of PTH , PDBu , and ionomycin on [PLD] , but not on calcium influx , were *prevented* by the inhibitors PD98059 and U0126 . Positive_regulation PLD5 S1PR3 12385647 1034848 We previously demonstrated that sphingosine 1-phosphate (S1P) induced [PLD] *activation* via the G-protein coupled receptor endothelial differentiation gene (EDG) <3/S1P(3)> was involved in S1P induced stimulation of PI 3-kinase and Akt . Positive_regulation PLD5 SNCAIP 12560086 1052749 *activated* [phospholipase D (PLD)] through a pertussis toxin-sensitive mechanism , also involving extracellular Ca2+ and PKC . Positive_regulation PLD5 SNCAIP 8049083 267421 Among the various sphingoid compounds , in addition to sphingosine , only *activated* the endothelial cell [PLD] . Positive_regulation PLD5 SPHK1 15109308 1272940 activity is *required* for sphingosine mediated [phospholipase D] activation in C2C12 myoblasts . Positive_regulation PLD5 SPHK1 9545263 498467 We show here that , in a human monocytic cell line primed with interferon-gamma , FcgammaRI mobilizes intracellular calcium stores using a novel pathway that involves tyrosine kinase coupling to [phospholipase D] and resultant downstream *activation* of . Positive_regulation PLD5 TNF 8444187 213646 *induced* [phospholipase D] activity was observed 1 h before the onset of cell killing and gradually increased thereafter . Positive_regulation PLD5 TNF 8444187 213652 Subclones selected for resistance to TNF cytotoxicity did not show [phospholipase D] activation in *response* to . Positive_regulation PLD5 TNF 8444187 213670 In contrast , when these subclones were treated with TNF in the presence of actinomycin D , TNF cytotoxicity as well as *induced* [phospholipase D] activity could be restored . Positive_regulation PLD5 TNF 8444187 213682 TNF cytotoxicity and *induced* [phospholipase D] activity were equally modulated by various drugs known to interfere with different steps in the TNF signaling pathway . Positive_regulation PLD5 TNF 8444187 213688 Prelabeling of cells with [ 14C ] lysophosphatidylcholine indicated phosphatidylcholine as one of the substrates for *activated* [phospholipase D] . Positive_regulation PLD5 TNF 9831076 551403 Moreover , a comparative study using TNF and anti-Fas antibodies as cell death stimuli showed that [PLD] and cPLA2 are specifically *activated* by . Positive_regulation PLD5 TNF 9873818 557019 Both and anti-Fas/Apo1 monoclonal antibody *increased* [PLD] activity in a dose dependent manner up to 200 U/ml and 200 ng/ml , respectively . Positive_regulation PLD6 ANGPT1 12890486 1117392 Interestingly , *increased* [PLD] activities in a dose- and time dependent manner . Positive_regulation PLD6 EDN2 1537886 180640 Phorbol esters and synthetic diglycerides mimicked the effects of endothelin to stimulate phospholipase D and inhibitors of protein kinase C significantly reduced *stimulated* [phospholipase D] . Positive_regulation PLD6 EDN2 1537886 180658 The calcium ionophore , ionomycin , did not stimulate phospholipase D and mesangial cells pretreated with BAPTA to chelate cytosolic calcium did not show a diminished *stimulated* [phospholipase D] . Positive_regulation PLD6 EDN2 8477817 218591 receptors *stimulate* both phospholipase C and [phospholipase D] activities in different cell lines . Positive_regulation PLD6 EDN2 8477817 218609 The *activation* of PLC or [PLD] by in the three cell lines was mediated by the high affinity binding site ( nM range ) and was not significantly affected by either extracellular or intracellular Ca2+ . Positive_regulation PLD6 EDN2 8717070 378863 4. *Activation* by of phosphatidylcholine-specific [phospholipase D] is under the dual regulation of protein kinase C and [Ca2+ ] i , with protein kinase C being the major regulator and [Ca2+ ] i playing a secondary , modulatory role . Positive_regulation PLD6 EPHB2 17030901 1630643 We report here , for the first time in HSC , that extracellular nucleotides stimulate [PLD] activity and a sustained *activation* of . Positive_regulation PLD6 F2R 11991733 938535 Here , we characterized [PLD] *activation* in neonatal rat cardiomyocytes by the PLC-stimulatory thrombin receptor , in comparison to the endothelin-1 receptor ET ( A ) R , which induces PLD stimulation by activation of protein kinase C (PKC) delta and epsilon . Positive_regulation PLD6 F2R 11991733 938541 Similar to ET ( A ) R , activation of *induced* [PLD] stimulation , which , however , was insensitive to PKC inhibition . Positive_regulation PLD6 F2R 11991733 938547 Furthermore , in contrast to ET ( A ) R , [PLD] *stimulation* by was suppressed by overexpression of regulators of G protein signaling specific for G ( 12 ) -type G proteins and treatment with brefeldin A , an inhibitor of guanine nucleotide exchange factors for ADP-ribosylation factor (ARF) GTPases . Positive_regulation PLD6 F2R 11991733 938553 We conclude that , in contrast to ET ( A ) R-PLD coupling , *induced* cardiomyocyte [PLD] stimulation is PKC independent and mediated by G ( 12 ) -type G proteins and ARF GTPases , while Rho and tyrosine kinases regulate PLD stimulation by either receptor , apparently by controlling the cellular level of PIP ( 2 ) , a common regulator of PLD activity . Positive_regulation PLD6 FAS 10395739 627545 mediated *activation* of [phospholipase D] is coupled to the stimulation of phosphatidylcholine-specific phospholipase C in A20 cells . Positive_regulation PLD6 FAS 10395739 627557 cross linking *resulted* in a both dose- and time dependent increases in [phospholipase D] activity . Positive_regulation PLD6 FAS 10395739 627563 Pretreatment of D609 also effectively inhibited the translocation of protein kinase C betaI and betaII from the cytosol to the membrane and the activation of [phospholipase D] *induced* by cross linking , suggesting that 1 , 2-diacylglycerol released from the cellular phosphatidylcholine pool through phosphatidylcholine-specific phospholipase C plays a major role in protein kinase C/phospholipase D activation . Positive_regulation PLD6 FAS 10395739 627569 Therefore , these results suggest that mediated [phospholipase D] *activation* may be a consequence of primary stimulation of phosphatidylcholine-specific phospholipase C and that phospholipase D may play a role in Fas cross linking signaling downstream from phosphatidylcholine-specific phospholipase C . Positive_regulation PLD6 FAS 10799296 691061 We have previously reported that cross linking *resulted* in an increase in [phospholipase D] activity in A20 murine cells ( J.-S . Positive_regulation PLD6 FAS 10799296 691067 These data suggest that Ras GTPase is essential in transmitting [phospholipase D] activation signal *induced* by cross linking and is located at phosphatidylcholine-specific phospholipase C upstream in Fas signaling cascades . Positive_regulation PLD6 FAS 11007187 735358 We have previously reported that cross linking *resulted* in the activation of phosphatidylcholine-specific phospholipase C ( PC-PLC ) and the subsequent activation of protein kinase C ( PKC ) and [phospholipase D (PLD)] in A20 cells . Positive_regulation PLD6 FAS 11007187 735390 In an attempt to correlate the existence of PC-PLC activity and *activation* of [PLD] by activation among various Fas expressing murine cell lines , we have investigated the effect of anti-Fas monoclonal antibody on PC-PLC and PLD activities in A20 , P388D1 and YAC-1 cell lines . Positive_regulation PLD6 FAS 11007187 735412 These findings suggest that the activation of PC-PLC is a necessary requirement for the *activation* of [PLD] by cross linking and cell lines devoid of functional PC-PLC activity could exhibit enhanced PLD activity by exogenous addition of PC-PLC . Positive_regulation PLD6 FAS 11152958 759025 When phosphatidylcholine-specific phospholipase C ( PC-PLC ) was inhibited by D609 , the *induced* changes in [PLD] activity , DAG content , and PKC translocation were inhibited . Positive_regulation PLD6 FAS 11152958 759031 In contrast , D609 had no effect on Fas induced alterations in sphingolipid metabolism , suggesting that changes in ceramide content do not account for induced [PLD] *activation* . Positive_regulation PLD6 FAS 11152958 759037 Furthermore , C6-ceramide had no effect on induced [PLD] *activation* and PKC translocation . Positive_regulation PLD6 FAS 11795496 892359 D609-sensitive tyrosine phosphorylation is involved in mediated [phospholipase D] *activation* . Positive_regulation PLD6 FAS 11795496 892365 Both and PMA can *activate* [phospholipase D] via activation of protein kinase Cbeta in A20 cells . Positive_regulation PLD6 FAS 11795496 892371 [Phospholipase D] activity was increased 4 fold in the *presence* of and 2.5 fold in the presence of PMA . Positive_regulation PLD6 FAS 11795496 892377 The possible involvement of tyrosine phosphorylation in induced *activation* of [phospholipase D] was investigated . Positive_regulation PLD6 FAS 11795496 892383 A tyrosine kinase inhibitor , genistein , can partially inhibit *induced* [phospholipase D] activation . Positive_regulation PLD6 FAS 11795496 892390 These results strongly indicate that tyrosine phosphorylation may in part account for the increase in phospholipase D activity by Fas cross linking and D609 can block not only PC-PLC activity but also tyrosine phosphorylation involved in *induced* [phospholipase D] activation . Positive_regulation PLD6 FAS 12216112 986270 In contrast , cross linking *stimulated* the activity of [PLD] , PC-PLC , and SMase , translocation of PKC , and protein phosphorylation in Fas-resistant clone # 11 , similar to that of wild type cells . Positive_regulation PLD6 GPR115 14501041 1183494 Measurement of *stimulated* [phospholipase D] activity in intact cells . Positive_regulation PLD6 GPR132 14501041 1183483 Measurement of *stimulated* [phospholipase D] activity in intact cells . Positive_regulation PLD6 GPR87 14501041 1183563 Measurement of *stimulated* [phospholipase D] activity in intact cells . Positive_regulation PLD6 IL1B 11854442 913961 The results of this study indicate that in human amnion cells , might *activate* [PLD] through an upstream protein kinase C to elicit p38 and finally induce COX-2 expression . Positive_regulation PLD6 IL1B 1333514 204406 *stimulated* protein kinase C , [phospholipase D] , and adenylyl cyclase activities ( 0 to 4 hours ) were unchanged from controls . Positive_regulation PLD6 ITGB2 17346796 1727092 Stable adhesion and migration of human neutrophils requires [phospholipase D-mediated] *activation* of the integrin . Positive_regulation PLD6 ITGB2 8872506 389671 bound to protein A-positive Staphylococcus aureus bacteria *induced* a significant [PLD] activation . Positive_regulation PLD6 MAP2K6 11278912 811562 [PLD] activation by AA and HETEs was *reduced* by inhibitors of Ras farnesyltransferase ( farnesyl protein transferase III and BMS-191563 ) and ( U0126 and PD98059 ) . Positive_regulation PLD6 MAP2K6 12929934 1132249 PTH activated p42/p44 MAP kinase , and the effects of PTH , PDBu , and ionomycin on [PLD] , but not on calcium influx , were *prevented* by the inhibitors PD98059 and U0126 . Positive_regulation PLD6 S1PR3 12385647 1034850 We previously demonstrated that sphingosine 1-phosphate (S1P) induced [PLD] *activation* via the G-protein coupled receptor was involved in S1P induced stimulation of PI 3-kinase and Akt . Positive_regulation PLD6 SNCAIP 12560086 1052750 *activated* [phospholipase D (PLD)] through a pertussis toxin-sensitive mechanism , also involving extracellular Ca2+ and PKC . Positive_regulation PLD6 SNCAIP 8049083 267422 Among the various sphingoid compounds , in addition to sphingosine , only *activated* the endothelial cell [PLD] . Positive_regulation PLD6 SPHK1 15109308 1272942 activity is *required* for sphingosine mediated [phospholipase D] activation in C2C12 myoblasts . Positive_regulation PLD6 SPHK1 9545263 498469 We show here that , in a human monocytic cell line primed with interferon-gamma , FcgammaRI mobilizes intracellular calcium stores using a novel pathway that involves tyrosine kinase coupling to [phospholipase D] and resultant downstream *activation* of . Positive_regulation PLD6 TNF 8444187 213647 *induced* [phospholipase D] activity was observed 1 h before the onset of cell killing and gradually increased thereafter . Positive_regulation PLD6 TNF 8444187 213653 Subclones selected for resistance to TNF cytotoxicity did not show [phospholipase D] activation in *response* to . Positive_regulation PLD6 TNF 8444187 213671 In contrast , when these subclones were treated with TNF in the presence of actinomycin D , TNF cytotoxicity as well as *induced* [phospholipase D] activity could be restored . Positive_regulation PLD6 TNF 8444187 213683 TNF cytotoxicity and *induced* [phospholipase D] activity were equally modulated by various drugs known to interfere with different steps in the TNF signaling pathway . Positive_regulation PLD6 TNF 8444187 213689 Prelabeling of cells with [ 14C ] lysophosphatidylcholine indicated phosphatidylcholine as one of the substrates for *activated* [phospholipase D] . Positive_regulation PLD6 TNF 9831076 551404 Moreover , a comparative study using TNF and anti-Fas antibodies as cell death stimuli showed that [PLD] and cPLA2 are specifically *activated* by . Positive_regulation PLD6 TNF 9873818 557020 Both and anti-Fas/Apo1 monoclonal antibody *increased* [PLD] activity in a dose dependent manner up to 200 U/ml and 200 ng/ml , respectively . Positive_regulation PLG ANGPT1 10807867 692379 *induced* the secretion of [plasmin] and matrix metalloproteinase-2 (MMP-2) , which is inhibited by PI 3'-kinase inhibitors . Positive_regulation PLG ANGPT1 11116055 757975 or VEGF induced migration and sprouting activity , *increased* [plasmin] and matrix metalloproteinase-2 secretion , and decreased tissue inhibitors of metalloproteinase type 2 secretion . Positive_regulation PLG ARSA 3143164 100910 Low and high concentrations of Col *stimulated* the release of [plasminogen activator-inhibitors (PA-I)] from platelets , and could not modify this release . Positive_regulation PLG EMP1 17606760 1792592 *induced* [plasmin] generation affects tube formation mediated by endothelial progenitor cells . Positive_regulation PLG EMP1 17606760 1792595 Prevention of these effects by inhibitors of either uPA or plasmin underscore the key role of *induced* [plasmin] generation . Positive_regulation PLG F2R 15894352 1458502 Thrombin , but not activating peptide or ADP , *stimulated* high-affinity binding of [plasminogen] and greatly promoted platelet dependent plasmin generation . Positive_regulation PLG F2R 19098386 2004024 The expression of PAR(1) on dopaminergic neurons is evident and the *activation* of by [plasmin] is demonstrated by assaying GTP-gammaS binding . Positive_regulation PLG F3 2304886 129818 These results suggest that the isolated effects of intravascular absorption of prostate tissue substances are due to disseminated intravascular coagulation , most likely resulting from tissue and *activation* of [plasminogen] . Positive_regulation PLG FHL1 19850343 2165358 Factor H and inactivate complement and [plasminogen] can be *activated* to plasmin which then degrades the extra-cellular matrix component fibrinogen . Positive_regulation PLG IL1B 12375736 996724 *regulates* cellular proliferation , prostaglandin E2 synthesis , [plasminogen] activator activity , osteocalcin production , and bone resorptive activity of the mouse calvarial bone cells . Positive_regulation PLG IL1B 12916707 1130059 *stimulated* cellular proliferation and the synthesis of prostaglandin E2 and [plasminogen] activator activity in the cultured cells in a dose dependent manner . Positive_regulation PLG IL1B 2784676 109059 *stimulated* cellular proliferation and the synthesis of prostaglandin E2 and [plasminogen] activator activity by the cultured human osteoblast-like cells . Positive_regulation PLG IL1B 3109443 75021 and interleukin-1 alpha *stimulate* the [plasminogen] activator activity and prostaglandin E2 levels of human synovial cells . Positive_regulation PLG IL1B 8601416 351864 *Upregulation* of cell-surface associated [plasminogen] activation in cultured keratinocytes by and tumor necrosis factor-alpha . Positive_regulation PLG MFI2 12750156 1119612 Regulation of [plasminogen] *activation* : a role for ( p97 ) in cell migration . Positive_regulation PLG MFI2 15936756 1433974 *Stimulation* of cell surface [plasminogen] activation by membrane bound : a key phenomenon for cell invasion . Positive_regulation PLG MFI2 16713448 1564819 *stimulates* t-PA dependent activation of [plasminogen] in endothelial cells leading to cell detachment . Positive_regulation PLG MFI2 16979249 1628099 We have recently demonstrated , that truncated human recombinant soluble ( sMTf ) could *stimulate* the activation of [Plg] by urokinase plasminogen activator and inhibit angiogenesis . Positive_regulation PLG MMP28 22798012 2645726 This effect resulted from the presence of the potent inhibitors , tissue inhibitor of metalloproteinases-1 ( TIMP-1 ) , type-1 [plasminogen] activator *inhibitor* ( PAI-1 ) and thrombospondin-1 (TSP-1) in the amnion dressings , as shown by real-time fluorescence zymography and protein microarrays . Positive_regulation PLG MMP7 16391791 1505828 On the other hand , [plasmin-treatment] *induced* the expression of matrix metalloproteinase-2 (MMP-2) , and MMP-9 in PC-1 cells . Positive_regulation PLG MMP7 22798012 2645741 This effect resulted from the presence of the potent inhibitors , tissue inhibitor of metalloproteinases-1 ( TIMP-1 ) , type-1 [plasminogen] activator *inhibitor* ( PAI-1 ) and thrombospondin-1 (TSP-1) in the amnion dressings , as shown by real-time fluorescence zymography and protein microarrays . Positive_regulation PLG PLAT 10318667 611846 Plg system components affect FCI at 2 different levels : ( 1 ) reduction of activity ( tPA gene inactivation ) reduces whereas its augmentation ( PAI-1 gene inactivation ) increases infarct size , and ( 2 ) reduction of [Plg] activity ( Plg gene inactivation or alpha2-AP injection ) *increases* whereas its augmentation ( alpha2-AP gene inactivation or alpha2-AP neutralization ) reduces infarct size . Positive_regulation PLG PLAT 10376931 623521 The *activation* of ubiquitous [plasminogen] by urokinase ( u-PA ) and , which is associated with various neuropathologies , including multiple sclerosis (MS) , is the key initiator of the activation cascade of the four classes of matrix metalloproteinases ( MMPs ) : collagenases , stromelysins , membrane-type metalloproteinases and gelatinases . Positive_regulation PLG PLAT 10632469 576578 In an in vitro test , bovine intestine dermatan sulfate exhibited stronger effects on stimulation of heparin cofactor II and *activation* of [Glu-plasminogen] by . Positive_regulation PLG PLAT 10764803 707573 Type 1 [plasminogen] activator *inhibitor* ( PAI-1 ) , the primary inhibitor of , circulates as a complex with the abundant plasma glycoprotein , vitronectin . Positive_regulation PLG PLAT 10800598 690438 Truncations in this region also have been found to introduce a new , non-enzymatic biological activity into aspartase , the ability to specifically enhance the *activation* of [plasminogen] to plasmin by . Positive_regulation PLG PLAT 10946092 722927 We tested this hypothesis by comparing the effects of histidine-rich glycoprotein and 6-aminohexanoic acid in an in vitro assay of fibrin dependent [plasmin] production *mediated* by . Positive_regulation PLG PLAT 11071275 748074 [Plasminogen] *activation* by was enhanced by the presence of L. mexicana promastigotes . Positive_regulation PLG PLAT 11112095 757520 Mechanism of enhancement by fucoidan and CNBr-fibrinogen digest of the *activation* of [glu-plasminogen] by . Positive_regulation PLG PLAT 11396898 823403 In this communication , data based on a chromogenic substrate assay are presented showing that plasminogen adsorbed to these surfaces is readily converted to [plasmin] in the *presence* of . Positive_regulation PLG PLAT 11400089 824366 Since urokinase ( UK ) has been withdrawn from the market , recombinant ( rt-PA ) has become the [plasminogen] *activator* of choice . Positive_regulation PLG PLAT 11460466 838815 or that become exposed as a consequence of the polymerization process ( e.g. , *dependent* [plasminogen] activation ) . Positive_regulation PLG PLAT 11689350 876195 tPA binding to K18 may be important in the mechanism whereby K8-K18 complexes promote [plasminogen] *activation* by . Positive_regulation PLG PLAT 11744725 915978 Type 1 [plasminogen] activator *inhibitor* ( PAI-1 ) , the primary inhibitor of , is found in plasma and platelets . Positive_regulation PLG PLAT 11775254 766385 The plasma level of platelet alpha-granular membrane protein-140 , soluble fibrinomonomer complex , thrombomodulin , and D-dimer significantly *increased* , fibrinogen , antigen level of protein C , [plasminogen] , alpha 2-plasminogen inhibitor and plasminogen activator inhibitor decreased at diagnosis , were restored to normal after complete remission but protein C activity and protein S remained elevated in ATRA group . Positive_regulation PLG PLAT 11802720 902939 It functions by removing C-terminal lysine residues from partially degraded fibrin that are important in *mediated* [plasmin] formation . Positive_regulation PLG PLAT 12035559 895115 [ [Plasminogen] *activation* by on fibrin clots with different surface structures ] . Positive_regulation PLG PLAT 12035559 895116 The [plasminogen] *activation* by the is one of the fibrinolysis system key reactions . Positive_regulation PLG PLAT 12035559 895117 We have studied the [plasminogen] *activation* by on fibrin clots surface formed on the interface between two phases and in presence of one phase . Positive_regulation PLG PLAT 12092294 960203 is a [plasminogen] *activator* that penetrates the thrombus and causes lysis . Positive_regulation PLG PLAT 12230559 988284 reduced rate of and membrane mediated [plasminogen] *activation* ; Positive_regulation PLG PLAT 12419183 1013134 This correlates with tPA binding and stimulation of mediated [plasminogen] *activation* . Positive_regulation PLG PLAT 12658774 1030337 In order to further investigate the effect of annexin II (Ann-II) on *dependent* [plasminogen (PLG)] activation and its interactive mechanism , recombinant native Ann-II bound t-PA , PLG and plasmin with high affinity was examined . Positive_regulation PLG PLAT 12695744 1081181 The effect of fucoidan , heparin and cyanogen bromide-fibrinogen on the *activation* of human [glutamic-plasminogen] by . Positive_regulation PLG PLAT 12695744 1081185 Earlier studies on the stimulatory effect of fucoidan , heparin , and cyanogen bromide ( CNBr ) -fibrinogen digest on the in-vitro *activation* of glutamic type [plasminogen] by , which were performed using subphysiologic ionic strengths of buffers , gave inconsistent results because of the variation in the ionic strengths of the buffers used . Positive_regulation PLG PLAT 12695744 1081187 The double reciprocal plots of the *activation* of glutamic type [plasminogen] by in the presence of fucoidan and 6-aminohexanoic acid ( 6-AH ) or heparin and 6-AH showed a four- to six-fold increase in K ( cat ) , while the K ( m ) remained unchanged . Positive_regulation PLG PLAT 12697748 1100077 Lp(a) may interfere with mediated [plasminogen] *activation* in fibrinolysis , thereby generating a hypercoagulable state in vivo . Positive_regulation PLG PLAT 12787697 1097037 the aortic matrix degradation in AAA may be partly caused by an *activation* of [plasminogen] by , but apparently not by uPA , which usually dominates matrix degradation . Positive_regulation PLG PLAT 12876631 1115432 The recently described thrombin-activatable fibrinolysis inhibitor ( TAFI ) attenuates fibrinolysis by cleaving of the C-terminal lysine residues from fibrin , thereby inhibiting *mediated* [plasminogen] activation . Positive_regulation PLG PLAT 1338753 209158 The structure basis of the poor fibrin specificity of urokinase ( II ) -- The inhibition of urokinase A chain 149-157 on the fibrin stimulated *activation* of [plasminogen] by . Positive_regulation PLG PLAT 1370273 179278 *mediated* activation of [plasminogen] on the surface of group A , C , and G streptococci . Positive_regulation PLG PLAT 1385938 190887 Ionic modulation of the effects of heparin on [plasminogen] *activation* by : the effects of ionic strength , divalent cations , and chloride . Positive_regulation PLG PLAT 1387641 196286 In the *presence* of fibrin II , and BatPA activated [Glu-plasminogen] with comparable catalytic efficiencies ( 158,000 and 174,000 M-1 s-1 , respectively ) . Positive_regulation PLG PLAT 1387641 196287 By comparison , a variety of monomeric and polymeric fibrin-like species markedly enhanced *mediated* activation of [Glu-plasminogen] . Positive_regulation PLG PLAT 1387993 196305 We have studied [plasminogen] activation *induced* by , as well as other fibrinolytic parameters , in 25 subjects with Lp(a) levels greater than 30 mg/dl and the results were compared with those found in 23 subjects with Lp(a) less than 30 mg/dl . Positive_regulation PLG PLAT 1445933 205263 trans-PGE2 was found to enhance [plasminogen (PLG)] activation *mediated* by ( tPA ) . Positive_regulation PLG PLAT 14515195 1147045 Active plasmin is generated by proteolytic *activation* of the zymogen [plasminogen (Plg)] by urokinase-type plasminogen activator ( uPA ) and ( tPA ) . Positive_regulation PLG PLAT 14580393 1156937 Further GAS with *activated* [plasminogen] bound on their surface penetrated through Transwell-grown pharyngeal cells in significantly higher numbers . Positive_regulation PLG PLAT 1471070 207155 In an in vitro model , we have studied the influence of purified Lp(a) lipoprotein on [plasminogen] *activation* by in the presence of soluble fibrin . Positive_regulation PLG PLAT 14743974 1182085 Mechanism of the stimulatory effect of 6-aminohexanoic acid on [plasminogen] *activation* by streptokinase or : the role of chloride . Positive_regulation PLG PLAT 14743974 1182087 Studies were conducted on the mechanism of the stimulatory effect of 6-aminohexanoic acid ( 6-AH ) during the in vitro *activation* of human glutamic [plasminogen] ( Glu-Plg ) by streptokinase or by and the possible role of the addition of physiological concentrations of NaCl to the buffer solution . Positive_regulation PLG PLAT 1489146 208403 [Plasminogen] activator activity was *due* to both and urokinase . Positive_regulation PLG PLAT 1497339 193456 Allosteric regulation of mediated [plasminogen] *activation* by a modifier mechanism : evidence for a binding site for plasminogen on the tPA A-chain . Positive_regulation PLG PLAT 1497339 193457 We found nonlinear Eadie-Scatchard plots for [Glu-plasminogen] *activation* by recombinant single-chain confirming a non-Michaelis-Menten behavior of tPA . Positive_regulation PLG PLAT 1497339 193458 When such a mechanism was included into a model for mediated [plasminogen] *activation* , the experimentally obtained data could be fitted into such a model by nonlinear regression analysis with resulting p-values of less than 0.001 . Positive_regulation PLG PLAT 15009457 1217843 CPU is able to slow down clot lysis by suppressing the cofactor activity of partially degraded fibrin in the [plasminogen] *activation* by . Positive_regulation PLG PLAT 15166035 1288300 We noted that many angiogenesis inhibitors stimulate mediated [plasminogen] *activation* . Positive_regulation PLG PLAT 15194650 1260090 Specific interaction of with annexin II on the membrane of pancreatic cancer cells *activates* [plasminogen] and promotes invasion in vitro . Positive_regulation PLG PLAT 15351852 1292664 A comparative study of amyloid-beta ( 1-42 ) as a cofactor for [plasminogen] *activation* by vampire bat plasminogen activator and recombinant human . Positive_regulation PLG PLAT 15379562 1298214 Lp(a) may interfere with mediated [plasminogen] *activation* in fibrinolysis , thereby generating a hypercoaguable state in vivo . Positive_regulation PLG PLAT 15574344 1355676 Active plasmin is generated by proteolytic *activation* of the zymogen [plasminogen (Plg)] by urokinase-type plasminogen activator ( uPA ) and ( tPA ) . Positive_regulation PLG PLAT 15574370 1355698 The carboxyl-terminal lysines of S100A10 bind tPA and plasminogen resulting in the stimulation of *dependent* [plasmin] production . Positive_regulation PLG PLAT 15678511 1376148 is the predominant [plasminogen] *activator* present in the vascular and nervous systems . Positive_regulation PLG PLAT 15726889 1352011 Mechanism of the stimulatory effect of native fucoidan , highly sulfated fucoidan and heparin on [plasminogen] *activation* by : the role of chloride . Positive_regulation PLG PLAT 15737740 1378672 Abeta40 as well as oligomeric and fibrillar forms of Abeta42 stimulated mediated [plasminogen] *activation* and cell detachment . Positive_regulation PLG PLAT 15749342 1379496 Amyloid-beta stimulated [plasminogen] *activation* by results in processing of neuroendocrine factors . Positive_regulation PLG PLAT 15788416 1403727 S100A4 alone or in a complex with annexin II accelerated mediated [plasminogen] *activation* in solution and on the endothelial cell surface through interaction of the S100A4 C-terminal lysines with the lysine binding domains of plasminogen . Positive_regulation PLG PLAT 15861134 1411194 is the main *activator* of [plasminogen] into plasmin in the brain where it may have beneficial roles but also neurotoxic effects that could be plasmin dependent or not . Positive_regulation PLG PLAT 1606292 189235 Comparison of fibrin mediated *stimulation* of [plasminogen] activation by and fibrin dependent enhancement of amidolytic activity of t-PA . Positive_regulation PLG PLAT 1636166 194315 The SF-ELISA immunologically measures the concentration of desAA- and desAABB-fibrin while the SF-tPA-test is based on *activation* of [plasminogen] by in the presence of fibrin ; Positive_regulation PLG PLAT 16438933 1521638 Structural basis of the cofactor function of denatured albumin in [plasminogen] *activation* by . Positive_regulation PLG PLAT 1678556 163301 The bacteria effectively promoted [plasminogen] *activation* by which was inhibited by epsilon-aminocaproic acid . Positive_regulation PLG PLAT 16913828 1602106 ( Retavase ) is a [plasminogen] *activator* , mimicking endogenous tissue plasminogen activator (t-PA) , a serine protease , converting plasminogen to plasmin and thereby precipitating thrombolysis . Positive_regulation PLG PLAT 1693270 132750 Moreover , vitronectin was found to inhibit in a dose dependent fashion the fibrin(ogen) induced *activation* of [plasminogen] by . Positive_regulation PLG PLAT 1697146 139512 Plasminogen was stable in equine plasma stored up to 1 week at 4 C and up to 5 months at -70 C . [Plasminogen] in nonacidified equine plasma was not *activated* by urokinase , streptokinase , , or tissue plasminogen activator plus soluble fibrin . Positive_regulation PLG PLAT 16979249 1628101 Since various angiogenesis inhibitors were shown to stimulate mediated [plasminogen] *activation* , we examined the effects of sMTf on tPA dependent fibrinolysis . Positive_regulation PLG PLAT 1699517 143266 The mechanism of *activation* of human [Glu-plasminogen] by fibrin bound in a plasma environment or in a reconstituted system was characterized . Positive_regulation PLG PLAT 1715763 149591 The rate enhancing effect of fibrin(ogen) fragments in [plasminogen] *activation* by is also disabled efficiently by these proteases . Positive_regulation PLG PLAT 17182930 1662685 The aortic matrix degradation in AAA may be partly caused by an *activation* of [plasminogen] by , but not by uPA , which usually dominates matrix degradation . Positive_regulation PLG PLAT 17213677 1689081 Though the odorless garlic preparation did not influence or its inhibitor secretions from human umbilical vein endothelial cells , it *enhanced* [plasmin] generation by t-PA on fibrin film and in chromogenic assays by 1.8-fold and 8.7-fold respectively . Positive_regulation PLG PLAT 17263591 1691345 ( Retavase ) is a [plasminogen] *activator* , mimicking endogenous tissue plasminogen activator (t-PA) , a serine protease , converting plasminogen to plasmin and thereby precipitating thrombolysis . Positive_regulation PLG PLAT 1731899 181393 The dissolution of blood clots by plasmin is normally initiated in vivo by the *activation* of [plasminogen] to plasmin through the activity of . Positive_regulation PLG PLAT 17379720 1715313 Strain ST1 of L. crispatus enhanced *activation* of human [Plg] by the , whereas enhancement of the urokinase mediated Plg activation was lower . Positive_regulation PLG PLAT 17452424 1778056 is the major *activator* of [plasminogen] in plasma . Positive_regulation PLG PLAT 17890121 1811198 Moreover , incubation of S. agalactiae with either plasminogen alone , or [plasminogen] plus fibrinogen , in the *presence* of enhanced its virulence in C57BL/6 mice , suggesting that acquisition of plasmin-like activity by the bacteria increase their invasiveness . Positive_regulation PLG PLAT 17895078 561857 is an unglycosylated [plasminogen] *activator* with enhanced fibrinolytic potency . Positive_regulation PLG PLAT 18000864 1846314 *mediated* generation of [plasmin] is catalyzed by the proteoglycan NG2 . Positive_regulation PLG PLAT 18180617 1856511 Effect of oversulfated chondroitin-6-sulfate or oversulfated fucoidan in the *activation* of glutamic [plasminogen] by : role of lysine and cyanogen bromide-fibrinogen . Positive_regulation PLG PLAT 18180617 1856513 Addition of 28.6 microg/ml oversulfated compound gave a two-fold to four-fold increase in the rate of enhancement of *activation* of glutamic [plasminogen] by using 0.05 mol/l Tris buffer ( pH 7.35 ) containing physiological concentrations of NaCl ( 0.9 % ) . Positive_regulation PLG PLAT 18180617 1856515 In the present study , the effect of lysine or cyanogen bromide treated fibrinogen , alone or in combination with the oversulfated compounds , on the *activation* of glutamic [plasminogen] by was investigated . Positive_regulation PLG PLAT 1824940 151470 An apparent Ki of 43 micrograms/ml was calculated for the inhibitory effect of fibronectin when [plasminogen] *activation* by recombinant single-chain was studied in the presence of 91 micrograms/ml FCB-2 . Positive_regulation PLG PLAT 18331597 1931925 We found that staphylokinase ( SAK ) , a well-known Plg activator of bacterial origin , inhibits [Plg] activation *mediated* by endogenous and uPA . Positive_regulation PLG PLAT 18331597 1931926 In conclusion , SAK reduces *mediated* [Plg] activation by means of SAK . Plg complex formation , consequently downregulating tPA/uPA induced fibrinolysis . Positive_regulation PLG PLAT 18685430 1949247 The result of the in-vitro studies of the *activation* of glutamic [plasminogen] by or by high-molecular-weight urokinase using 0.05 mol/l Tris buffer ( pH 7.35 ) containing a physiological concentration of NaCl ( 0.9 % ) showed that 28.6 microg/ml S-2 enhanced the activation by three-fold to four-fold by t-PA or by urokinase , while the same concentrations of N-2 or unfractionated heparin gave less than 30 % enhancement of t-PA and no enhancement of urokinase . Positive_regulation PLG PLAT 18690354 1949454 Here we show that PAI-2 can inhibit cell bound activity in vitro and thus *prevent* [plasmin] formation . Positive_regulation PLG PLAT 18690354 1949456 However , PAI-2 prevented *mediated* [plasminogen] activation by its classic serpin inhibitory activity rather than through competition with tPA/plasminogen for binding . Positive_regulation PLG PLAT 18690354 1949458 Further analysis showed that PAI-2 inhibited cell bound *induced* [plasmin] activity in both an AIIt dependent and -independent manner . Positive_regulation PLG PLAT 18983515 2001317 Several in vitro and in vivo studies have shown that Lp(a)/apo(a) can inhibit mediated [plasminogen] *activation* on fibrin surfaces , although the mechanism of inhibition by apo(a) remains controversial . Positive_regulation PLG PLAT 1899177 152049 The *activation* of native human [plasminogen] ( Glu1-Pg ) by , urinary plasminogen activator ( u-PA ) , and streptokinase is inhibited by the divalent cations Ca2+ , Mg2+ , and Mn2+ . Positive_regulation PLG PLAT 19017261 2016843 *Activation* of [plasminogen] by is enhanced in the presence of fibrin or at the endothelial cell surface . Positive_regulation PLG PLAT 1904231 159340 The glycoprotein ( t-PA , alteplase , CAS 105857-23-6 ) is a serine protease consisting of 527 amino acids and can *activate* [plasminogen] to plasmin , which subsequently dissolves the fibrin network of a thrombus . Positive_regulation PLG PLAT 1905851 161664 The stimulatory effect of soluble fibrin on [plasminogen] *activation* by as studied by the Coa-set Fibrin Monomer test . Positive_regulation PLG PLAT 1905851 161665 The stimulatory effect of various fibrin preparations on [plasminogen] *activation* by , was studied by the Coa-set Fibrin Monomer test ( Kabi ) . Positive_regulation PLG PLAT 1905925 161673 Structural requirements of position A alpha-157 in fibrinogen for the fibrin induced rate enhancement of the *activation* of [plasminogen] by . Positive_regulation PLG PLAT 1905925 161675 The sequence fibrinogen-A alpha- ( 148-160 ) can mimic part of the fibrin induced rate enhancement of the *activation* of [plasminogen] by . Positive_regulation PLG PLAT 19152657 2026841 Tetranectin enhances [plasminogen] *activation* by a so that it has been suggested to play a role in tissue remodeling . Positive_regulation PLG PLAT 19180513 2033164 beta2-glycoprotein i is a cofactor for mediated [plasminogen] *activation* . Positive_regulation PLG PLAT 19180513 2033165 The purpose of this study was to investigate the effects of beta(2)-glycoprotein I ( beta(2)GPI ) , an abundant plasma glycoprotein , on mediated [plasminogen] *activation* . Positive_regulation PLG PLAT 19180513 2033167 The effect of beta(2)GPI on *mediated* activation of [plasminogen] was assessed using amidolytic assays , a fibrin gel , and plasma clots . Positive_regulation PLG PLAT 19180513 2033172 The effects of IgG fractions and anti-beta(2)GPI antibodies from patients with antiphospholipid syndrome (APS) on mediated [plasminogen] *activation* were also measured . Positive_regulation PLG PLAT 19180513 2033174 Beta(2)-glycoprotein I stimulated *dependent* [plasminogen] activation in the fluid phase and within a fibrin gel . Positive_regulation PLG PLAT 19285282 2046545 Annexin II is a protein with high affinity for plasminogen and tissue-type plasminogen activator ( tPA ) , and also acts as a cofactor for [plasminogen] *activation* by . Positive_regulation PLG PLAT 1948823 171273 We measured antigen levels of two kinds of plasminogen activators , and urokinase type plasminogen activator ( UK ) , as well as their primary *inhibitor* , type-1 [plasminogen] activator inhibitor ( PAI-1 ) in the tissue extracts of benign and malignant breast tumors . Positive_regulation PLG PLAT 1966796 149811 When the patient 's plasma serpins were inhibited , [plasminogen] *activation* by in the presence of several fibrin concentrations was normal , suggesting that the formation of the ternary complex tPA - plasminogen - fibrin was not inhibited by the presence of high levels of Lp(a) . Positive_regulation PLG PLAT 1969852 130890 Synthesis , purification , and properties of a peptide that enhances the *activation* of human [ Glu1 ] [plasminogen] by and retards fibrin polymerization . Positive_regulation PLG PLAT 19809304 2180576 Fibrinogen was purified from the propositus ' and normal control plasma by immunoaffinity chromatography and was used for the following experiments : sodium dodecyl sulfate-polyacrylamide gel electrophoresis , fibrin polymerization , scanning electron microscopic observation of fibrin clot and fibers , clot lysis , and mediated [plasminogen] *activation* . Positive_regulation PLG PLAT 19916923 2166632 Angiostatin K1-3 ( up to 2 microM ) had no effect , while 2 microM angiostatins K1-4 and K1-4 .5 inhibited the fibrin stimulated [Glu-plasminogen] *activation* by by 50 and 100 % , respectively . Positive_regulation PLG PLAT 19916923 2166633 The difference in effects of the three angiostatins on the [Glu-plasminogen] *activation* by scuPA , tcuPA , and in the absence or presence of fibrin is due to the differences in angiostatin structures , mechanisms of action , and fibrin-specificity of plasminogen activators , as well as due to the influence of fibrin on the Glu-plasminogen conformation . Positive_regulation PLG PLAT 19931652 2210046 We now report that purified Xa33/13 increases *dependent* [plasmin] generation by at least 10-fold . Positive_regulation PLG PLAT 20019599 2200190 Displaying no differences from corresponding normal controls were ( a ) lysis of repolymerized fibrin clots , and ( b ) chromogenic measurements of fibrin stimulated [Glu-plasminogen] *activation* by recombinant . Positive_regulation PLG PLAT 20410502 2293977 Patients with FVL generate higher levels of soluble fibrin , which may serve as cofactor in *induced* [plasminogen] activation , leading to a more sustained activation of fibrinolysis with production of more fibrinogen- and fibrin-degradation products . Positive_regulation PLG PLAT 20425534 2247182 Some of these mechanisms include elevations in plasminogen activator inhibitor-1 levels , inhibitory antibodies against tPA or other components of the fibrinolytic system , antibodies against annexin A2 , and finally , antibodies to beta(2)-glycoprotein-I ( beta(2)GPI ) that block the ability of beta(2)GPI to stimulate mediated [plasminogen] *activation* . Positive_regulation PLG PLAT 20440070 2268336 In contrast , induced delayed IPC required the proteolytic activity of tPA and was *mediated* by [plasmin] , the NMDA receptor , and PKB phosphorylation . Positive_regulation PLG PLAT 21054978 2344593 The [plasminogen] *activation* <[tissue-type plasminogen activator> ( tPA ) and urokinase-type plasminogen activator ( uPA ) ] and vascular remodeling ( positive rates of internal elastic membrane , vascular perimeter and vessel wall stiffness index ) were detected by immunohistochemistry and Weigert Van Gieson staining respectively . Positive_regulation PLG PLAT 2107598 128736 The molecular interactions involved in the fibrin mediated *stimulation* of [plasminogen] activation by were studied using natural human plasminogen ( nPlg ) and rPlg-Ala740 , a recombinant human plasminogen in which the catalytic site is destroyed by mutagenesis of the active site Ser740 to Ala. Using this rPlg-Ala740 moiety , the dissociation constant of the interaction between plasminogen and CNBr digested fibrinogen was determined to be 0.40 microM . Positive_regulation PLG PLAT 2112791 135489 Differential effect of platelets on [plasminogen] *activation* by , urokinase , and streptokinase . Positive_regulation PLG PLAT 2114043 135612 We conclude that the incorporation of into fibrin and the in situ *activation* of [plasminogen] enhance local fibrinolysis , thereby increasing the risk of bleeding in patients undergoing open heart surgery . Positive_regulation PLG PLAT 21146216 2437423 SiRNA targetting Ann II caused a decrease in *dependent* [plasmin] generation , while Ann II cDNA transfectant stimulated plasmin production . Positive_regulation PLG PLAT 21194375 2396852 Angiostatin , LK68 and Lys-rhLK8 increased clot lysis time in a dose dependent manner , inhibited mediated [plasminogen] *activation* on a thrombin modified fibrinogen (TMF) surface , showed binding to TMF and significantly decreased the amount of plasminogen bound to TMF . Positive_regulation PLG PLAT 2128181 149284 Comparison of the effects of fibrinogen and fibrin products and isolated peptide chains on the fibrin mediated *stimulation* of [plasminogen] activation by , and on the fibrin dependent enhancement of the amidolytic activity of one-chain tissue-type plasminogen activator . Positive_regulation PLG PLAT 2128181 149285 They were also investigated for their ability to stimulate [plasminogen] *activation* by one-chain , which occurs via ternary complex formation . Positive_regulation PLG PLAT 2129390 150639 Kinetic studies of [plasminogen] *activation* by epithelial . Positive_regulation PLG PLAT 21346556 2411259 Effect of in-vitro addition of sulfated xylans , glucosans or chondroitins on the prothrombin time of human plasma and on the *enhancement* of activation of glutamic [plasminogen] by . Positive_regulation PLG PLAT 21346556 2411261 The results of in-vitro studies of the *activation* of glutamic [plasminogen] ( Glu-Plg ) by using 0.05 mol/l Tris buffer ( pH 7.35 ) containing physiological concentration of NaCl ( 0.9 % ) , showed that oat spelts xylan sulfate and amylopectin sulfate gave a 20-fold enhancement of the activation in a synergistic manner when used in combination with 32.4 mmol/l of lysine . Positive_regulation PLG PLAT 21392255 2426769 To identify the binding site for SP on plasminogen and elucidate the effects of SP on [plasminogen] *activation* by the . Positive_regulation PLG PLAT 2148848 146886 Effect of fibrin-like stimulators on the *activation* of [plasminogen] by -- studies with active site mutagenized plasminogen and plasmin resistant t-PA . Positive_regulation PLG PLAT 21737785 2476306 The presence of RBCs in the clot suppressed the *induced* [plasminogen] activation , resulting in 45 % less plasmin generated after 30 minutes of activation at 40 % ( v/v ) RBCs . Positive_regulation PLG PLAT 21899046 2478189 A decrease in the k ( Pg ) value and an increase in the K ( Pg ) value were found for fibrin stimulated [plasminogen] *activation* by with increasing concentrations of angiostatin . Positive_regulation PLG PLAT 21899046 2478190 In case of fibrin stimulated [plasminogen] *activation* by , both zymogen and tPA are bound to fibrin with formation of the effective triple tPA-Pg-fibrin complex . Positive_regulation PLG PLAT 21951786 2525406 M. hyopneumoniae surface bound [plasminogen] was *activated* by and is able to degrade fibrinogen , demonstrating the biological functionality of M. hyopneumoniae bound plasmin(ogen) upon activation . Positive_regulation PLG PLAT 21976662 2512845 DNA ( 0.1-5.0 µg/ml ) , but not RNA , potentiates the *activation* of Glu- and [Lys-plasminogen] by and uPA by 480- and 70-fold and 10.7- and 17-fold , respectively , via a template mechanism similar to that known for fibrin . Positive_regulation PLG PLAT 22003219 2513218 Increased and circulating fibrin *result* in increased [plasmin] generation , which removes hemostatic fibrin . Positive_regulation PLG PLAT 22003920 2516454 *Activation* of [plasminogen] to plasmin by staphylokinase or decreased in the presence of TPI , whereas TPI was degraded by plasmin . Positive_regulation PLG PLAT 22187433 2549492 Fibrin ( Fn ) enhances [plasminogen (Pg)] *activation* by ( tPA ) by serving as a template onto which Pg and tPA assemble . Positive_regulation PLG PLAT 22238323 2579931 Notably , plasmin and tPA activities , as well as *dependent* generation of [plasmin] in solution , are not decreased in the presence of Aß ( 42 ) . Positive_regulation PLG PLAT 22318336 2575925 Prior reports demonstrated that at least one herpesvirus expresses surface annexin A2 ( A2 ) , a cofactor for *dependent* activation of [plasminogen] to plasmin . Positive_regulation PLG PLAT 22318336 2575928 Herpes simplex virus types 1 ( HSV1 ) and 2 , and cytomegalovirus ( CMV ) purified from various cell lines each accelerated the proteolytic *activation* of [plasminogen] to plasmin by . Positive_regulation PLG PLAT 22974122 2713588 Binding of ( t-PA ) and Pgn to fibrin *regulates* [plasmin] generation , but there is no consistent , quantitative understanding of the individual contribution of t-PA finger and kringle 2 domains to the regulation of fibrinolysis . Positive_regulation PLG PLAT 23500465 2766655 Kallikreins 3 and 5 were able to induce plasmin activity after hydrolyzing plasminogen , and we also verified that [plasminogen] activation was *potentiated* in the presence of glycosaminoglycans compared with plasminogen activation by . Positive_regulation PLG PLAT 2437668 72931 The *activation* of a native form of [plasminogen] ( Glu-plg ) by was enhanced when the plasma was clotted by the addition of thrombin or thrombin plus Ca++ . Positive_regulation PLG PLAT 2441630 75846 *Activation* of [plasminogen] by ( tpA ) is potentiated by fibrin . Positive_regulation PLG PLAT 2470738 111683 The latter antibody also inhibited [plasminogen] *activation* by in the presence of CNBr-fibrinogen fragments in a dose dependent , apparently noncompetitive way . Positive_regulation PLG PLAT 2500878 113904 In human plasma , the *activation* of [plasminogen] by is a fibrin localized process which allows the specific dissolution of thrombi . Positive_regulation PLG PLAT 2503511 115218 Recombinant human ( rt-PA ) , produced by expression in Chinese hamster ovary cells , is a fibrin-specific [plasminogen] *activator* which has been approved for clinical use in the treatment of myocardial infarction . Positive_regulation PLG PLAT 2504719 117049 Anticoagulant low molecular weight heparin does not enhance the *activation* of [plasminogen] by . Positive_regulation PLG PLAT 2546631 115445 *Activation* of [plasminogen] by was enhanced by hepatocytes in primary culture . Positive_regulation PLG PLAT 2938632 58241 Fibrin and plasminogen structures essential to *stimulation* of [plasmin] formation by . Positive_regulation PLG PLAT 2940088 59386 MA-HAL did not influence the *activation* of [plasminogen] by in the absence of CNBr digested fibrinogen , but abolished the effect of CNBr digested fibrinogen on the Michaelis constant of the reaction . Positive_regulation PLG PLAT 2941084 59603 *Activation* of [plasminogen] by on normal and thrombasthenic platelets : effects on surface proteins and platelet aggregation . Positive_regulation PLG PLAT 2942536 60796 and urokinase *enhance* the binding of [plasminogen] to thrombospondin . Positive_regulation PLG PLAT 2943315 61919 Direct analyses of plasminogen activation by polyacrylamide gel electrophoresis demonstrate that heparin increases the *activation* of [plasminogen] by both and uPA . Positive_regulation PLG PLAT 2966802 92571 [Plasminogen] *activation* by in the presence of stimulating CNBr fragment FCB-2 of fibrinogen is a two-phase reaction . Positive_regulation PLG PLAT 2966802 92572 [Plasminogen] *activation* by is stimulated by fibrin . Positive_regulation PLG PLAT 2974648 101798 [Plasminogen] *activation* by in the presence of platelets . Positive_regulation PLG PLAT 2974648 101800 Platelets were found to provide a surface for *activation* of [plasminogen] by the at an optimum concentration and to potentiate the generation of plasmin by the amidolytic method , fibrin lysis time and fibrin plate method . Positive_regulation PLG PLAT 3083529 58633 Effects of fibrin on the enhanced *activation* of [plasminogen] by urokinase and : role of cross-link . Positive_regulation PLG PLAT 3087001 59926 The method is based on the principle that fibrin stimulates the *activation* of [plasminogen] by . Positive_regulation PLG PLAT 3127307 90464 The *activation* of [Glu1-plasminogen] ( Glu-Pg ) by streptokinase ( SK ) , urokinase ( UK ) and is under rigorous control by molecules such as epsilon-aminocaproic acid ( EACA ) , fibrinogen (Fg) , fibrin ( Fn ) and , as we have recently discovered , anions . Positive_regulation PLG PLAT 3131143 92694 The influence of fibrin(ogen) fragments on the kinetic parameters of the *mediated* activation of different forms of [plasminogen] . Positive_regulation PLG PLAT 3137140 95918 Kinetic analyses were made for the *activation* of [Glu-plasminogen] ( Glu-Plg ) by obtained from various sources . Positive_regulation PLG PLAT 3139399 97371 A factor from endothelium facilitates *activation* of [plasminogen] by . Positive_regulation PLG PLAT 3146348 102755 Effectors of the *activation* of human [ Glu1 ] [plasminogen] by human . Positive_regulation PLG PLAT 3146348 102757 The *activation* of human [ Glu1 ] [plasminogen] [ ( Glu1 ] Pg ) by human recombinant ( rec ) two-chain is inhibited by Cl- , at physiological concentrations , and stimulated by epsilon-aminocaproic acid ( EACA ) , as well as fibrin(ogen) . Positive_regulation PLG PLAT 3937289 55265 The potentiating effect of platelet on [plasminogen] *activation* by . Positive_regulation PLG PLAT 3937289 55268 The fibrinolysis potentiating substance in the platelets required the presence of both tPA and plasminogen , suggesting that it potentiates the *activation* of [plasminogen] by . Positive_regulation PLG PLAT 3937289 55269 Since platelets contain both activator ( s ) and inhibitor ( s ) of [plasminogen] *activation* by , a balance between activator ( s ) and inhibitor ( s ) in platelets may also be required for control of the fibrinolytic pathway . Positive_regulation PLG PLAT 4040660 51065 *Activation* of human [plasminogen] by human is accelerated in the presence of cyanogen bromide digests of human fibrin(ogen) . Positive_regulation PLG PLAT 6208894 43183 [Plasminogen] was *activated* by urokinase ( low fibrin-affinity ) or ( high fibrin-affinity ) . Positive_regulation PLG PLAT 6210307 44115 *increases* the binding of [glu-plasminogen] to clots . Positive_regulation PLG PLAT 6210307 44116 Porcine *increases* the binding of [125I-glu-plasminogen] to clots made from human plasma or purified fibrinogen in a time and t-PA concentration dependent fashion . Positive_regulation PLG PLAT 6229056 33142 Differences in effects of fibrin(ogen) fragments on the *activation* of [1-glu-plasminogen] and 442-val-plasminogen by . Positive_regulation PLG PLAT 6489341 42558 Stabilization of the Michaelis complex between urokinase and plasminogen by formation of a cyclic ternary complex with CNBr-Fg , which has been invoked to explain the dramatic stimulatory effect of CNBr-Fg on the *activation* of [plasminogen] by , does not appear to play a significant role in the increased activation rate . Positive_regulation PLG PLAT 6538196 35557 Kinetics of the *activation* of [plasminogen] by natural and recombinant . Positive_regulation PLG PLAT 6538196 35559 The present findings obtained in a homogenous liquid milieu support the previously proposed mechanism of the *activation* of [plasminogen] by in the presence of fibrin . Positive_regulation PLG PLAT 6539000 38041 The fibrin mediated enhancement of the *activation* of [plasminogen] by observed with normal fibrin , is strongly decreased with fibrin Dusard , although the binding of tissue-type plasminogen activator to this fibrin is normal . Positive_regulation PLG PLAT 6543039 44403 Importance of the interaction between plasminogen and fibrin for [plasminogen] *activation* by . Positive_regulation PLG PLAT 6543039 44404 The potentiating effect of fibrin monomer on [plasminogen] *activation* by is much more important with lys-plasminogen than with mini-plasminogen ( which lacks the high affinity lysine binding site important for binding to fibrin ) . Positive_regulation PLG PLAT 6543039 44412 Binding does however not seem to be the only condition required since it was found that fragment D is a much stronger potentiator of the *activation* of [plasminogen] by than fragment E although plasminogen binds to both fragment D and fragment E . Positive_regulation PLG PLAT 6543039 44414 Furthermore , fragment E has the same effect on the *activation* of lys-and [mini-plasminogen] by . Positive_regulation PLG PLAT 6725259 38548 Cross linked [Glu-plasminogen] is slowly *activated* by urokinase and melanoma , but in contrast with uncross linked Glu-plasminogen conversion to Lys-plasminogen or saturation of lysine binding sites with ligand does not increase the rate of activation because the cross-link prevents transition to the loose conformer which is susceptible to activation . Positive_regulation PLG PLAT 6782183 15005 It was found that uterine and urokinase are two immunologically distinct [plasminogen] *activators* . Positive_regulation PLG PLAT 7199524 20128 Kinetics of the *activation* of [plasminogen] by human . Positive_regulation PLG PLAT 7199524 20130 The kinetics of the *activation* of Glu-plasminogen and [Lys-plasminogen (P)] by a two-chain form of human were studied in purified systems , and in the presence of fibrinogen ( f ) and of fibrin films ( F ) of increasing size and surface density . Positive_regulation PLG PLAT 7517736 243628 The degradation of the fibrin clot involves the tissue-type plasminogen activator , which like the uPA *activates* [plasminogen] to plasmin . Positive_regulation PLG PLAT 7642304 317966 Typhimurium SH401-1 was able to bind plasminogen and to enhance the *mediated* activation of the single-chain [plasminogen] to the two-chain plasmin . Positive_regulation PLG PLAT 7696314 297288 [Plasminogen] *activation* by two-chain urokinase-type plasminogen activator ( urokinase ) , two-chain tissue-type plasminogen activator ( tc-tPA ) or trypsin , but not by single chain ( sc-tPA ) is increased 5- to 10-fold by both substrates , as determined by electrophoretic and spectrophotometric kinetic analysis . Positive_regulation PLG PLAT 7696314 297291 It is concluded that plasmin substrates containing a lysine residue have a general capacity to enhance plasminogen activation presumably by inducing a conformational change in the native zymogen in a manner similar to 6-aminohexanoate , while the same substrates are inhibitory both on the amidolytic activity of and the *activation* of native and [des1-77-plasminogen] by sc-tPA . Positive_regulation PLG PLAT 7700563 288341 ( tPA ) is the main [plasminogen] *activator* associated with isolated rat nerve growth cones . Positive_regulation PLG PLAT 7711034 298026 Antifibrinolytic effect of recombinant apolipoprotein(a) in vitro is primarily due to attenuation of mediated [Glu-plasminogen] *activation* . Positive_regulation PLG PLAT 7711034 298028 The two components of the antifibrinolytic effect of r-apo(a) were determined to be ( i ) attenuation of mediated [plasminogen] *activation* ( the major component ) and ( ii ) inhibition of plasmin degradation of fibrin , although r-apo(a) did not directly attenuate plasmin activity , as measured by S-2251 hydrolysis . Positive_regulation PLG PLAT 7711034 298029 r-Apo(a) interfered most substantially with *mediated* activation of [Glu-plasminogen] and less substantially with tPA mediated Lys-plasminogen activation and urokinase mediated activation of plasminogen . Positive_regulation PLG PLAT 7711034 298030 In summary , we have demonstrated that apo(a) is able to attenuate fibrin clot lysis in vitro , primarily as a consequence of the interference by apo(a) with mediated [Glu-plasminogen] *activation* . Positive_regulation PLG PLAT 7711052 298032 The N-linked sugar on plasminogen ( at Asn-288 ) within kringle 3 reduces the rate of the beta- to alpha-conformational change , modulates the transport of plasminogen into the extravascular compartment , decreases plasminogen binding to U937 cells and downregulates the *activation* of [plasminogen] by both urokinase and . Positive_regulation PLG PLAT 7797579 314043 Fibrin clot lysis mediated by tissue-type plasminogen activator was accelerated for the variants as a result of a lower Km for mediated [plasminogen] *activation* , resulting from the increased affinity of rPlg ( variants ) for intact fibrin . Positive_regulation PLG PLAT 7814888 292814 mediated [plasminogen] *activation* was enhanced in the presence of C7 . Positive_regulation PLG PLAT 7992241 282966 The degradation of fibrin by human neutrophil elastase ( HNE ) and the interference of such degradation on the stimulating effect of fibrin on [plasminogen] *activation* by was studied . Positive_regulation PLG PLAT 8052969 267803 Plasminogen activation assays showed that this could *induce* [plasminogen] activation to form plasmin . Positive_regulation PLG PLAT 8128448 242062 As reported in recent literature , heparin stimulated the *activation* of [Lys-plasminogen] by high molecular weight ( HMW ) and low molecular weight ( LMW ) two-chain urokinase-type plasminogen activator ( u-PA ) and two-chain 10- to 17-fold . Positive_regulation PLG PLAT 8149527 252765 is the principal *activator* of [plasminogen] . Positive_regulation PLG PLAT 8187237 256711 Effects of lipoprotein(a) on the binding of [plasminogen] to fibrin and its *activation* by fibrin bound . Positive_regulation PLG PLAT 8329699 223525 The contribution of apo(a) polymorphism to the inhibition of fibrinolysis , a mechanism that may favor thrombus development , was therefore evaluated by measuring the ability of Lp(a) particles of distinct apo(a) isoform content to compete with plasminogen for fibrin binding during [plasminogen] *activation* by fibrin bound . Positive_regulation PLG PLAT 8341074 226202 This study shows that plasminogen activating activity is present in pericardial tissue and that is the major [plasminogen] *activator* . Positive_regulation PLG PLAT 8367835 229343 Our results suggest that rPAI-1 , by inhibiting both *induced* plasmin generation and [plasmin] activity directly , may have clinical value for improving platelet function during and after CPB . Positive_regulation PLG PLAT 8373773 229754 Lipoprotein(a) : a kinetic study of its influence on fibrin dependent [plasminogen] *activation* by prourokinase or . Positive_regulation PLG PLAT 8454185 215276 Mycoplasma cells stimulate in vitro *activation* of [plasminogen] by purified . Positive_regulation PLG PLAT 8454185 215277 In an in vitro direct assay with tissue-type plasminogen activator ( tPA ) , plasminogen and the chromogenic substrate S-2251 , the ability of Mycoplasma fermentans KL4 to stimulate mediated *activation* of [plasminogen] to plasmin was studied . Positive_regulation PLG PLAT 8454185 215279 Mycoplasma cells markedly enhanced the *activation* of [plasminogen] by in a concentration- , temperature- and pH-dependent manner . Positive_regulation PLG PLAT 8457641 215634 The stimulatory effects of these fibrin(ogen) preparations on [plasminogen] *activation* by were studied . Positive_regulation PLG PLAT 8501135 220938 We have shown ( Bizik et al. , Cell Regul 1 : 895-905 , 1990 ) that can *activate* [plasminogen] on the surface of human melanoma cells in the presence of alpha 2-macroglobulin (alpha 2M) secretion . Positive_regulation PLG PLAT 8509362 221576 is a poor *activator* of [plasminogen] , but its catalytic efficiency is greatly enhanced in the presence of fibrin or certain fibrin derivatives . Positive_regulation PLG PLAT 8578474 337477 These observations suggest that [plasminogen] *activation* by is an autocatalytic process on the platelet surface , and that unique reciprocating mechanisms govern the interaction between platelets and the components of the plasminogen activator system . Positive_regulation PLG PLAT 8585005 331381 Using plasma samples from healthy blood donors , patients with cerebral ischemic insult , patients with septicemia , and patients with venous thrombosis , we compared two immunologic tests using monoclonal antibodies against fibrin-specific neo-epitopes , and two functional tests based on the cofactor activity of soluble fibrin complexes in *induced* [plasminogen] activation . Positive_regulation PLG PLAT 8608343 342790 The secreted and the surface associated plasminogen activator (PA)-activity of HaCaTras cells were in part inhibitable by anticatalytic anti-tPA antibodies , thus indicating that *contributes* to extracellular and surface associated [plasminogen] activation . Positive_regulation PLG PLAT 8641739 362879 During both models of hyperinsulinemia , [plasminogen] activator inhibitor activity and antigen decreased significantly ( both P < .001 ) , and activity *increased* significantly ( P < . Positive_regulation PLG PLAT 8810346 383322 Cell-surface cytokeratin 8 is the major plasminogen receptor on breast cancer cells and is required for the accelerated *activation* of cell associated [plasminogen] by . Positive_regulation PLG PLAT 8810346 383323 [Plasminogen] *activation* by was greatly accelerated , due to a large decrease in Km , when the plasminogen was bound to MCF-7 cells . Positive_regulation PLG PLAT 8810346 383325 These studies identify cell-surface CK 8 as a major plasminogen receptor in breast cancer cells and as a required component for the rapid *activation* of cell associated [plasminogen] by . Positive_regulation PLG PLAT 8869642 344912 Fibrin dependent [plasminogen] *activation* by is in part associated with the presence of the kringle 2 domain in t-PA . Positive_regulation PLG PLAT 8872134 389640 Reexamination of the extent of the *activation* of Lys78 [plasminogen] by in the presence of polymerized fibrin . Positive_regulation PLG PLAT 8922633 397175 Matrigel reconstitution and incubation at 37 degrees C caused activation of [plasminogen] , which was serine protease dependent and *involved* as an anti-tPA antibody which inhibited activation . Positive_regulation PLG PLAT 8954829 401064 This antibody , known to inhibit tPA binding to its receptor , did not inhibit *induced* [plasmin] generation . Positive_regulation PLG PLAT 8968395 402679 Both compounds inhibited plasminogen activator inhibitor-1 activity in an amidolytic assay of *mediated* [plasmin] generation . Positive_regulation PLG PLAT 9036151 413856 A steady-state template model that describes the kinetics of fibrin stimulated [ Glu1 ] - and [ Lys78 ] [plasminogen] *activation* by native and variants that lack either the finger or kringle-2 domain . Positive_regulation PLG PLAT 9076449 420351 ( tPA ) is the chief [plasminogen] *activator* in the blood , but its activity is restricted by plasminogen activating inhibitors type 1 ( PAI-1 ) and type 2 ( PAI-2 ) . Positive_regulation PLG PLAT 9102401 419240 In contrast , native HPRG bound to hydrazide or nickel chelate surfaces strongly stimulated the *activation* of [plasminogen] by , but not by urokinase or streptokinase . Positive_regulation PLG PLAT 9120402 419257 These studies demonstrate that plasminogen plays an important role in protecting the glomerulus from acute inflammatory injury and that is the major protective [plasminogen] *activator* . Positive_regulation PLG PLAT 9141488 428411 Myosin binds both tPA and plasminogen , and enhances *activation* of [des1-77-plasminogen] by but not by urokinase-type plasminogen activator ( uPA ) . Positive_regulation PLG PLAT 9141488 428413 Myosin decreases K ( M ) and increases k ( cat ) for [des1-77-plasminogen] *activation* by , to yield catalytic efficiencies in excess of 8000 M-1 s-1 . Positive_regulation PLG PLAT 9253802 447648 The acceleration of *induced* [plasmin] generation in the presence of low concentration of L-arginine , along with augmentation of in vitro fibrinogenolysis have been documented . Positive_regulation PLG PLAT 9264548 449337 *Activation* of covalently intact [plasminogen] by ( tPA ) is facilitated by a majority of proteins subjected to denaturing conditions . Positive_regulation PLG PLAT 9282789 451530 Fibrin dependent *mediated* activation of [plasminogen] is associated with exposure of polymerization dependent epitopes ( Aalpha148-160 , gamma312-324 ) that are expressed in assembled fibrin and in crosslinked ( polymerized ) fibrinogen but not in unpolymerized fibrinogen or fibrin . Positive_regulation PLG PLAT 9315555 455820 In vitro studies have demonstrated that Lp(a) indeed competes with plasminogen binding to fibrin and inhibits *mediated* activation of [plasminogen] . Positive_regulation PLG PLAT 9342217 458809 ( tPA ) *activates* [plasminogen] to the active protease plasmin and is implicated in many biological processes that require extracellular proteolysis . Positive_regulation PLG PLAT 9357156 461952 The latter entails the controlled , localised conversion of plasma zymogen plasminogen to the active enzyme [plasmin] *mediated* by ( tPA ) . Positive_regulation PLG PLAT 9398610 469023 [Plasminogen] *activation* by is accelerated by the presence of a macromolecular surface , which acts as a template that brings enzyme and substrate in close proximity . Positive_regulation PLG PLAT 9520937 493669 We have investigated the expression and cellular localization of urokinase-type plasminogen activator ( uPA ) , ( tPA ) , urokinase-type plasminogen activator receptor ( uPAR ) , and plasminogen activator inhibitor-1 ( PAI-1 ) as well as [plasminogen] *activation* in rat liver regeneration by recruitment of progenitor ( oval ) cells . Positive_regulation PLG PLAT 9569195 501420 Polymerized fibrin strongly enhances mediated [plasminogen] *activation* , concomitant with exposure of ` fibrin-specific ' epitopes at ` Aalpha148-160 ' and ` gamma312-324 ' . Positive_regulation PLG PLAT 9569195 501421 Crosslinked normal fibrinogen , fibrinogen with deficient [ des Bbeta1-42 ] or defective [ Birmingham ( AalphaR16H ) ] fibrin ` D : E ' assembly sites ( ` E ( A ) ' ) , or with defective end-to-end self-association sites ( ` D : D ' ) [ Cedar Rapids ( gammaR275C ) ] , exposed both ` fibrin-specific ' epitopes and enhanced *dependent* [plasminogen] activation , whereas non crosslinked fibrinogens showed minimal or no such activities . Positive_regulation PLG PLAT 9662163 518222 K- and , at concentrations as high as 10 microg/ml of blood , *caused* [plasminogen] activation that was controlled by the natural plasmin inhibitors , and , thus , no proteolytic degradation of plasma fibrinogen ( fibrinogenolysis ) . Positive_regulation PLG PLAT 9730836 530296 The bovine single-chain mediated *activation* of bovine [plasminogen] was studied in the presence and absence of fibrinogen fragments . Positive_regulation PLG PLAT 9763537 537125 is the major [plasminogen] *activator* responsible for dissolving blood clots found in blood vessels . Positive_regulation PLG PLAU 10190291 603365 mediated [plasminogen] *activation* facilitates cell migration and invasion through extracellular matrices by dissolving connective tissue components . Positive_regulation PLG PLAU 10340907 616213 receptor ( uPAR ) is functionally *involved* in the cell surface activation ( i.e. , cleavage ) of [plasminogen] . Positive_regulation PLG PLAU 10500311 648175 Saruplase , or unglycosylated , single-chain ( scu-PA ) selectively *activates* fibrin bound [plasminogen] , and is subsequently converted to its two-chain derivative tcu-PA ( urokinase ) by plasmin . Positive_regulation PLG PLAU 10650871 578037 ( u-PA ) is one major *activator* of [plasminogen] . Positive_regulation PLG PLAU 10928473 719617 *Activation* of [plasminogen] bound to surface associated MIP-2alpha by two-chain ( tcu-PA ) was about 2.5-fold more efficient than in solution ( catalytic efficiency k ( cat ) K ( M ) of 0.1 microM ( -1 ) s ( -1 ) , as compared to 0.04 microM ( -1 ) s ( -1 ) . Positive_regulation PLG PLAU 10959704 726286 The assay is based on *activation* of [plasminogen] by human ( uPA ) and simultaneous measurement of generated plasmin with the specific plasmin substrate H-D-Val-Phe-Lys-4-nitroanilide ( S-2390 ) , using purified native rat plasminogen for calibration . Positive_regulation PLG PLAU 10974349 729299 C-I-H enhanced the *activation* of Glu- and [Lys-plasminogen] by high molecular weight ( HMW u-PA ) very effectively , but the activation by low molecular weight u-PA was hardly enhanced with C-I-H . Positive_regulation PLG PLAU 11016879 736528 The generation of the broad specificity serine protease [plasmin] in the pericellular environment is *regulated* by binding of the ( uPA ) to its specific glycosylphosphatidylinositol (GPI) anchored cell-surface receptor , uPAR . Positive_regulation PLG PLAU 11016879 736534 In both cell-lines , *activated* cell associated [plasminogen] with characteristics both qualitatively and quantitatively indistinguishable from those of uPAR bound uPA . Positive_regulation PLG PLAU 11016879 736535 By contrast , *activated* cell associated [plasminogen] less efficiently . Positive_regulation PLG PLAU 11027463 738934 The following activation mechanism for proteinase might occur : coexpressed with MMP-9 *activated* [plasminogen] , and plasmin activated proMMP-3 , which was secreted depending upon inflammatory infiltration , and then MMP-3 activated proMMP-9 , resulting in colorectal cancer progression and metastasis . Positive_regulation PLG PLAU 11238111 790476 A similar severe regeneration deficit with persistent fibrin deposition was also reproducible in plasminogen-deficient mice after injury , suggesting that fibrinolysis by mediated [plasminogen] *activation* plays a fundamental role in skeletal muscle regeneration . Positive_regulation PLG PLAU 11323016 807246 *Activation* of cell bound [plasminogen] by two-chain ( tcu-PA ) was not significantly different with SMC or fibroblasts from the gene-deficient mice ( 78 % to 140 % of wild-type ) . Positive_regulation PLG PLAU 11359936 816739 Moreover , *dependent* [plasmin] generation and the ability of HT1080 cells to migrate through Matrigel coated invasion chambers are also inhibited in the presence of D3 . Positive_regulation PLG PLAU 11422178 830895 In the present study , to clarify whether uPAR and *activated* [plasmin] are actually involved in the blistering process after pemphigus IgG binding to the cell surface , we examined the effects of the following on uPAR expression and on cell-cell detachment in DJM-1 cells , a squamous cell carcinoma line : ( i ) phosphatidylinositol-specific phospholipase C ( PI-PLC ) - which releases uPAR from the membrane surface into the culture medium by cleaving the glycosylphosphatidylinositol anchor thus inhibiting uPAR activity , and ( ii ) uPA inhibitors ( tranexamic acid , aprotinin , p-aminobenzonic acid and dexamethasone ) . Positive_regulation PLG PLAU 11689350 876197 The membrane macromolecule that is responsible for plasminogen binding and for supporting *activation* of [plasminogen] by on the surfaces of these cell types remains to be determined . Positive_regulation PLG PLAU 11929773 927277 Because we found that uPA , but not tPA , was induced in skeletal muscle regeneration , and persistent fibrin deposition was also reproducible in uPA-deficient mice following injury , we propose that fibrinolysis by *dependent* [plasmin] activity plays a fundamental role in skeletal muscle regeneration . Positive_regulation PLG PLAU 12138369 969228 In contrast , binding and *activation* of [plasminogen] by single-chain ( scu-PA ) at the surface of blood monocytes and alveolar macrophages were not different from those of control values . Positive_regulation PLG PLAU 12142372 969569 Paradoxically , high concentrations of [plasminogen] activator *inhibitor* ( PAI-1 ) , an endogenous inhibitor of , also correlate with poor prognosis in patients with breast cancer , including the subgroup with node negative disease . Positive_regulation PLG PLAU 12182908 977901 It was shown that *induced* activation of [Glu-plasminogen] or Lys-plasminogen was significantly inhibited in the presence of ATF . Positive_regulation PLG PLAU 12182908 977903 In addition , sc-uPA activation to two-chain uPA ( tc-uPA ) by Lys-plasmin and [plasminogen] *activation* to plasmin by were both found to be inhibited by ATF . Positive_regulation PLG PLAU 12182908 977907 In contrast to sc-uPA induced Glu- or Lys-plasminogen activation , sc-uPA induced mini-plasminogen activation , sc-uPA *activation* by [mini-plasmin] and mini-plasminogen activation by were not affected by ATF . Positive_regulation PLG PLAU 12189157 997756 The *role* of and its receptor ( CD87 ) in [plasminogen (Plg)] activation , cell adhesion , and chemotaxis is well established ; Positive_regulation PLG PLAU 12427882 1014776 A marked increase in *dependent* [plasminogen] activation was detected in the CSF of patients with bacterial meningitis vs CSF of patients with GBS and controls . Positive_regulation PLG PLAU 12431907 1054937 To address the hypothesis that the liver injury in transgenic mice results from the intracellular *activation* of [plasminogen] by transgene derived ( uPAT ) , we generated mice that overexpress uPAT and lack functional plasminogen ( uPAT-Plg ( - ) ) . Positive_regulation PLG PLAU 12485432 1025058 Exposure of keratinocyte cultures to hypoxia resulted in upregulation of urokinase plasminogen activator mRNA and a subsequent increase in mediated [plasminogen] *activation* , as determined by indirect chromogenic peptide assay and plasminogen linked zymography . Positive_regulation PLG PLAU 12529357 1071070 It did not block [plasminogen] *activation* by activated in clot lysis and chromogenic substrate assays . Positive_regulation PLG PLAU 12534347 1071125 However , in spite of this very fast inhibition , two-chain still became the dominant [plasminogen] *activator* when plasminogen was incubated with pro-uPA and PAI-1 . Positive_regulation PLG PLAU 12543785 1050812 Besides degrading of matrix proteins , PMN-E has been shown to be able to cleave and inactivate plasminogen activator inhibitor-1 ( PAI-1 ) , the main inhibitor of , and alpha2-antiplasmin , the natural *inhibitor* of [plasmin] , thus enabling an uncontrolled matrix degradation by the fibrinolytic enzymes . Positive_regulation PLG PLAU 12750156 1119616 Moreover , the *activation* of [plasminogen] by is increased by soluble p97 . Positive_regulation PLG PLAU 12853975 1110181 In these tumors , the expression pattern of and PAI-1 resembles that of human ductal breast cancer and [plasminogen] is *required* for efficient metastasis . Positive_regulation PLG PLAU 12871064 1112318 ( uPA ) *activates* [plasminogen] to plasmin and is often associated with diseases where tissue remodeling is essential ( e.g. cancer , macular degeneration , atherosclerosis ) . Positive_regulation PLG PLAU 12915673 1129968 To date , the factors capable of regulating the coordinate expression of the urokinase-type plasminogen activator ( ) and its endogenous *inhibitor* , [plasminogen] activator inhibitor ( PAI-1 ) , at the maternal-fetal interface remain poorly characterized . Positive_regulation PLG PLAU 14515195 1147046 Active plasmin is generated by proteolytic *activation* of the zymogen [plasminogen (Plg)] by ( uPA ) and tissue-type plasminogen activator ( tPA ) . Positive_regulation PLG PLAU 14644129 1171983 Expression levels of mRNA , protein , and activities of were significantly higher ( p < 0.005 ) and *resulted* in more [plasminogen] activation in UCT-2 than in UCT-1 . Positive_regulation PLG PLAU 14707491 1196571 We found that in vitro , Neovastat at 100 microg/ml markedly stimulates t-PA mediated plasmin generation , while it slightly inhibits the generation of [plasmin] *mediated* by . Positive_regulation PLG PLAU 14769799 1235286 The binding of to alpha ( M ) beta ( 2 ) was *critical* for the alpha ( M ) beta ( 2 ) -mediated enhancement of [plasmin (Plm)] generation , because this effect was lost when WT-sc-uPA was replaced with a kringle-less mutant ( DeltaK-sc-uPA ) , which does not bind to alpha ( M ) beta ( 2 ) . Positive_regulation PLG PLAU 1515091 196762 Hence receptor bound will *promote* [plasminogen] activation and thus the dissolution of the tumor matrix and the basement membrane which is a prerequisite for invasion and metastasis . Positive_regulation PLG PLAU 1531956 183285 Removal of cell associated considerably *reduced* [plasmin] generation on these cells . Positive_regulation PLG PLAU 15353482 1359038 *Activation* of [plasminogen] by plays important roles in several physiologic and pathologic conditions . Positive_regulation PLG PLAU 15353482 1359041 In contrast , neither Glunor Lys-plasminogen inhibits the *activation* of [plasminogen] by 2-chain . Positive_regulation PLG PLAU 15353482 1359042 These studies provide insight into the regulation of mediated [plasminogen] *activation* and identify a novel mechanism for its fibrin specificity . Positive_regulation PLG PLAU 15574344 1355677 Active plasmin is generated by proteolytic *activation* of the zymogen [plasminogen (Plg)] by ( uPA ) and tissue-type plasminogen activator ( tPA ) . Positive_regulation PLG PLAU 15574344 1355678 Previous studies have unambiguously demonstrated that *dependent* [plasmin] generation is necessary for myogenesis in vitro and for muscle regeneration in vivo . Positive_regulation PLG PLAU 15574370 1355702 S100A10 also colocalizes plasminogen with the uPA-uPAR complex thereby localizing and stimulating *dependent* [plasmin] formation to the surface of cancer cells . Positive_regulation PLG PLAU 15615772 1361867 Abeta aggregates *induce* expression thereby increasing [plasmin] , which degrades both aggregated and non aggregated forms of Abeta . Positive_regulation PLG PLAU 15885322 1406801 To evaluate the potential role of the uPAR/uPA/PAI-1 system in HIV induced blood-brain-barrier ( BBB ) disruption , CSF dependent [plasminogen] *activation* ( PdPA ) was analyzed by casein zymography , and CSF protein levels of all three molecules were measured by ELISA . Positive_regulation PLG PLAU 16231330 1483643 [Glu-plasminogen] *activation* by is strongly promoted by fibrin fragment E but not fibrin fragment D-dimer , whereas plasminogen activation by t-PA is strongly promoted by fragment D-dimer but not fragment E . Positive_regulation PLG PLAU 16391791 1505825 Furthermore , significantly *induced* the expression of [plasmin(ogen)] and uPAR in the conditioned medium of non dissociated ( PC-1 ) pancreatic cancer cells . Positive_regulation PLG PLAU 1639775 194685 [Plasminogen] *activation* by single-chain or pro-urokinase ( pro-UK ) is accompanied by the generation of two-chain urokinase ( UK ) by plasmin which provides a positive feedback . Positive_regulation PLG PLAU 16525582 1531588 On CHO cell depleted of uPAR , *enhanced* [plasminogen] activation in a kringle and alpha v beta 3-dependent manner . Positive_regulation PLG PLAU 16554301 1562049 2 ) activation of plasminogen by and subsequent *activation* of transforming growth factor-beta1 ( TGF-beta1 ) and matrix metalloproteinase (MMP)-2 and -9 by [plasmin] are critical pathways through which uPA expressing macrophages accumulate in the heart and cause fibrosis ; Positive_regulation PLG PLAU 16676075 1558932 Although the *roles* of and PAI-1 in [plasmin] generation and the degradation of fibrin are well known , recent evidence also suggests that they can participate in acute inflammatory conditions that involve neutrophil activation . Positive_regulation PLG PLAU 16734779 1566246 It has been recently shown that [plasminogen] binding to M. fermentans in the *presence* of the promotes the invasion of host cells by this organism . Positive_regulation PLG PLAU 16794252 1625117 ( urokinase-type plasminogen activator ) *activates* [plasminogen] with high efficiency when bound to its cellular receptor uPAR , but only after a prolonged lag phase during which generated plasmin activates pro-uPA . Positive_regulation PLG PLAU 16979249 1628100 We have recently demonstrated , that truncated human recombinant soluble melanotransferrin ( sMTf ) could stimulate the *activation* of [Plg] by and inhibit angiogenesis . Positive_regulation PLG PLAU 17134505 1661456 *activates* [plasminogen] and promotes liver matrix proteolysis during repair via a process that neither requires its receptor uPAR nor requires a contribution from its functional counterpart tPA . Positive_regulation PLG PLAU 17257442 1710448 Cell-surface [plasminogen] binding was significantly enhanced in the *presence* of elevated levels of in an activity dependent manner and was greatly attenuated in the presence of the plasmin inhibitor aprotinin . Positive_regulation PLG PLAU 17257442 1710449 We show that the majority of lysine dependent plasminogen binding to breast cancer cells is ultimately regulated by [plasmin] activity and is *dependent* on the presence of significant levels of active . Positive_regulation PLG PLAU 17506371 1744686 TGF-beta1 is activated by plasmin , which is formed when [plasminogen] is *activated* by ( uPA ) . Positive_regulation PLG PLAU 17606760 1792590 The generation of [plasmin] *involved* expression of ( uPA ) and its receptor ( uPAR ) at the surface of EMPs and was further increased by their ability to bind exogenous uPA on uPAR . Positive_regulation PLG PLAU 17716658 1801388 The *dependent* [plasminogen] activation in G93A mice at endstage increased markedly compared with controls and immunostaining of the spinal cord from G93A mice revealed increased uPAR immunostaining in neurons . Positive_regulation PLG PLAU 1828371 158638 This treatment exhaustively inactivated the Tc-uPA contaminant but did not affect Sc-uPA , as evidenced by the lack of significant incorporation of radiolabeled inhibitor in Sc-uPA and full *activation* of the inhibitor treated by [plasmin] . Positive_regulation PLG PLAU 1828371 158640 Fibrin , a positive effector of [plasminogen] *activation* by or Sc-uPA preparations in the absence of DFP and dansyl-EGRck , did not promote cleavage of plasminogen or S-2444 by Sc-uPA in the presence of the Tc-uPA inhibitors . Positive_regulation PLG PLAU 1829461 161325 Therefore , the cellular binding of Plg appears to be of critical importance for the efficient *activation* of [Plg] by receptor bound . Positive_regulation PLG PLAU 1829461 161326 Together , these data demonstrate that the cell surface constitutes the preferential site for [Plg] *activation* when is bound to its specific cellular receptor , which therefore has the necessary characteristics to play an efficient role in the generation of pericellular proteolytic activity . Positive_regulation PLG PLAU 18331597 1931927 In conclusion , SAK reduces mediated [Plg] *activation* by means of SAK . Plg complex formation , consequently downregulating tPA/uPA induced fibrinolysis . Positive_regulation PLG PLAU 18472961 1910443 ( uPA ) , a serine protease , can *activate* [plasminogen] and stimulate signaling events on binding its receptor uPAR . Positive_regulation PLG PLAU 18855679 1977184 Whereas uPAR has a well established role in regulating and focalizing mediated [plasminogen] *activation* to the surface of those cells expressing the receptor , the biological function of C4.4A remains elusive . Positive_regulation PLG PLAU 19123477 2037343 [Plasmin(ogen)] is *activated* on cell surfaces by , and is regulated by uPAR and plasminogen activator inhibitor-1 ( PAI-1 ) . Positive_regulation PLG PLAU 1948823 171274 We measured antigen levels of two kinds of plasminogen activators , tissue type plasminogen activator (t-PA) and ( UK ) , as well as their primary *inhibitor* , type-1 [plasminogen] activator inhibitor ( PAI-1 ) in the tissue extracts of benign and malignant breast tumors . Positive_regulation PLG PLAU 19666776 2138691 These complexes promote mediated [plasminogen] *activation* in scuPA treated rabbits with TCN induced pleural injury . Positive_regulation PLG PLAU 1969415 128685 The mechanism of the *activation* of [plasminogen] by single-chain ( single-chain u-PA , scu-PA ) was studied using rscu-PA-Glu158 , a recombinant plasmin-resistant mutant of human scu-PA obtained by site-specific mutagenesis of Lys158 to Glu , and rPlg-Ala740 , a recombinant human plasminogen in which the catalytic site is destroyed by mutagenesis of the active-site Ser740 to Ala. Conversion of 125I labeled single-chain plasminogen to two-chain plasmin was quantitated on reduced sodium dodecyl sulfate-gel electrophoresis combined with autoradiography and radioisotope counting of gels bands . Positive_regulation PLG PLAU 19699300 2202718 These results demonstrate that LRP1 regulates ECM remodeling principally by repressing pathways that require [plasminogen] *activation* by in association with uPAR . Positive_regulation PLG PLAU 19845941 2160220 In this study we show that the monoclonal antibody that recognizes an epitope on the cytokeratin 8 (CK8) ectoplasmic domain ( anti-CK MAb ) inhibits [plasminogen] activation *mediated* by ( uPA ) in MCF-7 and MCF-10A neoT cells . Positive_regulation PLG PLAU 20180903 2307277 *Activation* of single-chain by platelet associated [plasminogen] : a mechanism for stimulation of fibrinolysis by platelets . Positive_regulation PLG PLAU 20693403 2437275 This study shows that airway smooth muscle *activation* of [plasminogen] by is accelerated in a collagen-rich environment in which the inhibitory effect of TGF-ß is attenuated in association with greater uPA expression induced via ß1-integrin signaling . Positive_regulation PLG PLAU 21054978 2344594 The [plasminogen] *activation* [tissue-type plasminogen activator ( tPA ) and ( uPA ) ] and vascular remodeling ( positive rates of internal elastic membrane , vascular perimeter and vessel wall stiffness index ) were detected by immunohistochemistry and Weigert Van Gieson staining respectively . Positive_regulation PLG PLAU 2157592 131458 On the surface , can *activate* surface bound [plasminogen] to produce surface bound plasmin . Positive_regulation PLG PLAU 2157592 131461 In the *presence* of PAI-1 activity is inhibited and [plasmin] production interrupted , while the uPA-PAI-1 complex is internalized and degraded . Positive_regulation PLG PLAU 21707479 2515884 The primary function of this glycolipid anchored receptor is to focalize mediated [plasminogen] *activation* at the cell surface , which is accomplished by its high-affinity interaction with the growth factor-like domain of uPA . Positive_regulation PLG PLAU 21940822 2507174 [Plasminogen] *activation* by ( uPA ) was markedly inhibited ( by 39 % ) by treatment with anti-Plg-R(KT) mAb . Positive_regulation PLG PLAU 21976662 2512846 DNA ( 0.1-5.0 µg/ml ) , but not RNA , potentiates the *activation* of Glu- and [Lys-plasminogen] by tPA and by 480- and 70-fold and 10.7- and 17-fold , respectively , via a template mechanism similar to that known for fibrin . Positive_regulation PLG PLAU 22013113 2503308 In congenital heart block ( CHB ) , binding of maternal anti-SSA/Ro Abs to fetal apoptotic cardiocytes impairs their removal by healthy cardiocytes and increases receptor (uPAR) *dependent* [plasmin] activation . Positive_regulation PLG PLAU 23125522 2696313 The interaction enhances uPA concentrations on the cell surface and *enhances* [plasminogen] activation on the cell surface . Positive_regulation PLG PLAU 23158318 2700097 If the tested protein had plasminogen binding capability , the remaining [plasminogen] would be *activated* by to plasmin , which caused crystal migration through the matrix gel . Positive_regulation PLG PLAU 23341464 2753962 Moreover , upon *activation* of PepO bound [plasminogen] by , generated plasmin cleaved complement protein C3b thus assisting in complement control . Positive_regulation PLG PLAU 23835563 2839027 To investigate the prognostic value of urokinase-type plasminogen activator ( ) and its *inhibitor* , type-1 [plasminogen] activator inhibitor ( PAI-1 ) , in differentiated thyroid cancer . Positive_regulation PLG PLAU 23943648 2861829 ( uPA ) *activates* [plasminogen (Plg)] through a major pericellular proteolytic system involved in cell migration and angiogenesis ; Positive_regulation PLG PLAU 23943648 2861830 however , the Plg receptor that participates in mediated [Plg] *activation* has not yet been identified . Positive_regulation PLG PLAU 23943648 2861831 In conclusion , we propose that TM is a novel Plg receptor that regulates receptor *mediated* [Plg] activation and pericellular proteolysis within lipid rafts at the leading edge of migrating cells during angiogenesis . Positive_regulation PLG PLAU 23997178 2866513 and products of its degradation *contributed* to durable intrapleural [plasminogen] activation up to 24 h after IPFT . Positive_regulation PLG PLAU 24111848 2867816 In this study , the effect of mediated [plasminogen] *activation* on airway smooth muscle ( ASM ) cell proliferation was investigated . Positive_regulation PLG PLAU 2544876 114122 [Plasminogen] activator activity of these cells is *dependent* on exogenous , is competed for by receptor binding diisopropyl fluorophosphate treated uPA , and is inhibited by the addition of PAI-1 . Positive_regulation PLG PLAU 2713507 111197 The relative contribution of several mechanisms to [plasminogen] *activation* and fibrin dissolution by ( u-PA ) in vitro was quantitated . Positive_regulation PLG PLAU 2943315 61920 Direct analyses of plasminogen activation by polyacrylamide gel electrophoresis demonstrate that heparin increases the *activation* of [plasminogen] by both tPA and . Positive_regulation PLG PLAU 3023326 65682 These data show that secreted can find its way to the specific surface receptor without previous conversion to the two-chain form and that , once bound , can be *activated* by [plasmin] . Positive_regulation PLG PLAU 3139404 97372 Single-chain ( scu-PA ) *activates* [plasminogen] directly but with a catalytic efficiency which is about 20 times lower than that of urokinase . Positive_regulation PLG PLAU 3609016 76717 Effect of the cyanogen-bromide-2 fragment of fibrinogen on [plasminogen] *activation* by single-chain . Positive_regulation PLG PLAU 3609016 76719 *Activation* of [Glu-plasminogen] by single-chain ( sc-uPA ) , isolated from human urine , was studied in a purified system in the absence and presence of the cyanogen bromide fibrinogen fragment , FCB 2 , and compared to plasminogen activation by two-chain high-Mr urokinase . Positive_regulation PLG PLAU 3609016 76720 [Plasminogen] *activation* by was significantly increased by the FCB-2 fibrinogen fragment , an effect brought about by decrease of apparent Km and increase of apparent kcat . Positive_regulation PLG PLAU 3778931 65261 Comparative kinetic analysis of the *activation* of human [plasminogen] by natural and recombinant single-chain . Positive_regulation PLG PLAU 7556434 327669 When bound to this receptor , *activates* [plasminogen] , which is derived from plasma or the interstitial fluids . Positive_regulation PLG PLAU 7556451 327681 Receptor bound *activates* [plasminogen] , thus providing plasmin for pericellular proteolysis . Positive_regulation PLG PLAU 7588568 333888 *activates* [plasminogen] to plasmin which in turn degrades extracellular matrix proteins or activates other proteases . Positive_regulation PLG PLAU 7696314 297289 [Plasminogen] *activation* by two-chain ( urokinase ) , two-chain tissue-type plasminogen activator ( tc-tPA ) or trypsin , but not by single chain tPA ( sc-tPA ) is increased 5- to 10-fold by both substrates , as determined by electrophoretic and spectrophotometric kinetic analysis . Positive_regulation PLG PLAU 7734357 305357 Binding of to uPAR *leads* to an enhanced [plasmin] formation and thereby an amplification of pericellular proteolysis . Positive_regulation PLG PLAU 7776154 309247 Therefore , the enhancement of [plasmin] activity in the conditioned medium was *dependent* on increased activity via the decrease of the PAI-1 level of Gin-1 cells treated with C. rectus LPS . Positive_regulation PLG PLAU 7925643 273530 Our findings support the hypothesis that mediated [plasminogen] *activation* is characteristic of mobile rather than sessile keratinocytes . Positive_regulation PLG PLAU 8050560 267526 [Plasminogen] activation is *regulated* by the interaction between ( uPA ) and its specific glycolipid anchored cell surface receptor ( uPAR ) . Positive_regulation PLG PLAU 8128448 242063 As reported in recent literature , heparin stimulated the *activation* of [Lys-plasminogen] by high molecular weight ( HMW ) and low molecular weight ( LMW ) two-chain ( u-PA ) and two-chain tissue-type plasminogen activator (t-PA) 10- to 17-fold . Positive_regulation PLG PLAU 8203466 261036 The findings point at the importance of monocytes/macrophages and fibroblasts in mediated [plasminogen] *activation* in healing human skin wounds . Positive_regulation PLG PLAU 8257443 238569 Suramin inhibited [plasmin] *activation* of by a non-competitive mechanism ( Ki approx. 2 micrograms/ml ) , which did not involve a direct effect on plasmin catalytic activity . Positive_regulation PLG PLAU 8257443 238570 Similarly , its effect on [plasminogen] activation was not *due* to a direct inhibition of . Positive_regulation PLG PLAU 8444857 213708 We have observed that a murine IgG1 monoclonal antibody directed against human urokinase-type plasminogen activator ( uPA ) greatly potentiates *mediated* [plasminogen] activation . Positive_regulation PLG PLAU 8495419 219504 Specifically , cell surface receptor bound *activates* [plasminogen] to the potent general protease plasmin , which then degrades extracellular matrix or basement membrane either directly or via proteolytic activation of latent collagenases . Positive_regulation PLG PLAU 8601416 351866 [Plasminogen] that is also bound to specific membrane binding sites is readily *activated* by uPA-R bound . Positive_regulation PLG PLAU 8804418 382167 This delay of the activation system was shown to include a partial inhibition of the plasmin mediated activation of pro-uPA as well as of the *mediated* activation of [plasminogen] . Positive_regulation PLG PLAU 8822588 384845 [Plasminogen] *activation* by ( uPA ) is implicated in tumor invasion and metastasis by the breakdown of extracellular matrix . Positive_regulation PLG PLAU 8883968 390994 Activation of [plasminogen] is *initiated* by . Positive_regulation PLG PLAU 8912717 395463 [Plasminogen] , which is also bound to membrane binding sites , is readily *activated* by uPA-R bound . Positive_regulation PLG PLAU 8972026 402892 The localization *enhances* [plasmin] formation on the cell surface and facilitates cell migration . Positive_regulation PLG PLAU 9141488 428412 Myosin binds both tPA and plasminogen , and enhances *activation* of [des1-77-plasminogen] by tPA but not by ( uPA ) . Positive_regulation PLG PLAU 9249034 446554 The pro-uPA/uPAR- ( 1-281 ) -peptide complex and also showed a similar extent of plasminogen activation as measured by SDS/PAGE , when incubated with plasminogen and Spl in the presence of 100 micro M aprotinin , and [plasminogen] activation by pro-uPA alone was also *stimulated* in the presence of Spl in this assay . Positive_regulation PLG PLAU 9287983 452412 *regulates* [plasmin] generation from plasminogen . Positive_regulation PLG PLAU 9345041 459297 Thrombin stimulation of platelets induces [plasminogen] activation *mediated* by endogenous . Positive_regulation PLG PLAU 9347794 460590 These results suggest that enhanced urokinase plasminogen activator activity and receptor expression *activates* [plasmin] in the limited cell surface of pemphigus IgG bound keratinocytes and may contribute to the pathogenesis of differential acantholysis in pemphigus vulgaris and pemphigus foliaceus . Positive_regulation PLG PLAU 9391721 467746 Moreover , in the presence of increasing amounts of heparin , [plasminogen] activation *mediated* by occurred as a bell shaped curve , suggesting the formation of a ternary complex . Positive_regulation PLG PLAU 9425170 481579 Receptor independent *role* of in pericellular [plasmin] and matrix metalloproteinase proteolysis during vascular wound healing in mice . Positive_regulation PLG PLAU 9516128 493072 Moreover , VN-mediated binding of the *led* to a fivefold increase in [plasminogen] activator activity . Positive_regulation PLG PLAU 9520937 493670 We have investigated the expression and cellular localization of ( uPA ) , tissue-type plasminogen activator ( tPA ) , urokinase-type plasminogen activator receptor ( uPAR ) , and plasminogen activator inhibitor-1 ( PAI-1 ) as well as [plasminogen] *activation* in rat liver regeneration by recruitment of progenitor ( oval ) cells . Positive_regulation PLG PLAU 9521847 493837 They amplified plasminogen activation in culture supernatants up to 70-fold by stimulating ( i ) pro-uPA activation by plasmin and ( ii ) [plasminogen] *activation* by . Positive_regulation PLG PLAU 9649555 515370 mediated [plasminogen] *activation* in arthritic joints may have deleterious effects via degradation of cartilage and bone matrix proteins as well as beneficial effects via fibrin degradation . Positive_regulation PLG PLAU 9690792 523073 ( uPA ) *activates* [plasminogen] to plasmin , which is involved in the degradation of the vascular basement membrane and extracellular matrix . Positive_regulation PLG PLAU 9843416 553061 [Plasminogen] *activation* by the ( uPA ) is facilitated in the presence of cells expressing the glycolipid anchored high-affinity receptor for uPA ( denoted uPAR ) . Positive_regulation PLG PLAU 9846056 553843 The urokinase-type [plasminogen] ( uP ) is *activated* by u-PA and receptor ( uPAR ) . Positive_regulation PLG SERPINA5 10739384 679691 Bovine has a unique reactive site and can transiently *inhibit* [plasmin] . Positive_regulation PLG TNF 1311745 179043 We determine how recombinant interferon-gamma (IFN) and *regulate* [plasminogen] activation in monoblast-like U937 cells and normal human monocytes . Positive_regulation PLG TNF 1433370 204611 The results suggest a positive association between and rapid *induction* of [plasminogen] activator activity that is consistent with an endothelial product . Positive_regulation PLG TNF 14534369 1165047 and troglitazone *regulate* [plasminogen] activator inhibitor type 1 production through extracellular signal regulated kinase- and nuclear factor-kappaB dependent pathways in cultured human umbilical vein endothelial cells . Positive_regulation PLG TNF 1714936 164920 induced a brief fourfold *increase* in the overall plasma [plasminogen activator (PA)] activity peaking after 1 h ( p less than 0.0001 ) , which was associated with rises in the antigenic levels of urokinase-type plasminogen activator ( p less than 0.0001 ) and tissue-type plasminogen activator ( p less than 0.0001 ) . Positive_regulation PLG TNF 19638263 2143130 mediated [plasminogen] *activation* on neutrophils is involved in the high plasmin activity in mammary secretion of drying-off cows . Positive_regulation PLG TNF 20118172 2287316 Amphetamine ( 10 ( -7 ) -10 ( -4 ) mol/L ) enhanced thrombin- and tumour necrosis factor (TNF)-alpha induced as well as basal TF expression ( P = 0.029 , 0.0003 , and 0.003 at maximal concentration ) , and *induced* [plasminogen activator inhibitor (PAI)-1] expression ( P = 0.003 ) , whereas tissue factor pathway inhibitor expression was impaired ( P = 0.008 ) . Positive_regulation PLG TNF 7810674 284993 Conversely , *increased* [plasminogen activator (PA)] activity due to increased uPA . Positive_regulation PLG TNF 8601416 351863 *Upregulation* of cell-surface associated [plasminogen] activation in cultured keratinocytes by interleukin-1 beta and . Positive_regulation PLG TNF 8679225 372513 Phorbol myristate acetate , lipopolysaccharide , transforming growth factor-beta ( TGF-beta ) , and *increased* uPA binding and [plasminogen] activation at the cell surface , with a greater maximal effect on fibrotic than on normal fibroblasts . Positive_regulation PLG TP63 12913003 1150903 Furthermore , heterologous expression of an N-terminally truncated mutant of , which targets exclusively to the plasma membrane , *led* to an increase in tPA catalyzed [plasminogen] activation . Positive_regulation PLIN1 EPHB2 21701568 2505184 These findings demonstrate that SAA induced lipolysis is a result of downregulation of [perilipin] and *activation* of HSL via and PKA signaling pathways . Positive_regulation PLIN1 FAS 23606724 2795226 To understand how *regulate* [Plin] genes , we used specific activators and antagonists against PPARs , Plin promoter reporter assays , chromatin immunoprecipitation , siRNA , and animal models . Positive_regulation PLIN2 NPNT 23663413 2791172 APOA1 , DCN and expression was higher in cyclic compared to pregnant heifers , and pregnancy *increased* ( P < 0.05 ) the expression of LCAT , NCDN , NMN , [PLIN2] and TINAGL1 . Positive_regulation PLIN2 TNF 19088826 2003761 *increased* the protein levels of [ADRP] , downregulated perilipin proteins but promoted its phosphorylation level . Positive_regulation PLIN4 FAS 23606724 2795228 Our analyses demonstrate that *require* PPARd to induce transcription of [Plin4] and Plin5 . Positive_regulation PLIN5 FAS 23606724 2795229 Our analyses demonstrate that *require* PPARd to induce transcription of Plin4 and [Plin5] . Positive_regulation PLK1 AXIN2 16815967 1586078 High expression compromises the spindle checkpoint , and this *requires* localized [polo-like kinase 1] activity . Positive_regulation PLK1 FOXO1 18356527 1887683 In proliferating cells , Cdk1 induced FOXO1 Ser249 phosphorylation at the G2/M phase of the cell cycle , resulting in *dependent* expression of the mitotic regulator [Polo-like kinase (Plk)] . Positive_regulation PLK1 STK39 18083840 1837392 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation PLN ADRB2 12618231 1065817 stimulation *induces* protein kinase A-dependent [phospholamban] phosphorylation in both adult cardiomyocytes and in adult hearts of rats . Positive_regulation PLN TNF 16447655 1495619 can *increase* the expression of [PLB] and decrease delta [ Ca2+ ] i in cardiomyocytes , which may be related with its negative inotropic effects on cardiomyocytes . Positive_regulation PLN TNF 17913704 1830216 Together with cPLA(2) redistribution and AA release , *induced* a time dependent phosphorylation of ERK , MSK1 , PKCzeta , CaMKII , and [phospholamban] on the threonine 17 residue . Positive_regulation PLOD2 CTGF 24192939 2897113 For this study , we investigate if transforming growth factor-beta ( TGF-ß ) and *regulate* procollagen-lysine , 2-oxoglutarate 5-dioxygenase 2 ( PLOD2 ) ( gene encoding LH2b ) and [LH2b] expression differently in osteoarthritic human synovial fibroblasts ( hSF ) . Positive_regulation PLSCR1 IL1B 17590392 1792433 These results indicate that maximal stimulation of [PLSCR1] by LPS in liver *required* TNFalpha and/or , whereas the stimulation of PLSCR1 in adipose tissue is not dependent on TNFalpha and/or IL-1beta . Positive_regulation PLSCR1 TNF 17590392 1792428 TNFalpha , IL-1beta , and IL-6 all stimulated PLSCR1 in cultured Hep B3 hepatocytes , whereas only *stimulated* [PLSCR1] in cultured 3T3-L1 adipocytes , suggesting cell type-specific effects of cytokines . Positive_regulation PLSCR1 TNF 17590392 1792432 These results indicate that maximal stimulation of PLSCR1 by LPS in liver required TNFalpha and/or IL-1beta , whereas the stimulation of [PLSCR1] in adipose tissue is not *dependent* on and/or IL-1beta . Positive_regulation PLTP EPHB2 22034170 2599389 The inhibition of activity with specific inhibitors significantly *suppressed* Ox-LDL induced TGF-ß1 production , Smad3 phosphorylation and [PLTP] expression . Positive_regulation PMEL CTGF 23681229 2785466 Our studies are the first to demonstrate that reduced as an unfavorable prognosis factor *mediates* the activation of miR-18b , an oncomir directly suppresses CTGF expression , by [PI3K/AKT/C-Jun] and C-Myc and promotes cell growth of NPC . Positive_regulation PMEL EPHB2 21034655 2338914 Axotomy dramatically *increased* the expressions of P-JNK and [P-c-jun] ( paired t-test ) , with no influence on the expressions of P-p38 and . Positive_regulation PMEL TNF 12709443 1100438 Moreover , we show that RelB , p50 , and p100 can associate in the same complex and that but not LTbeta signaling *increases* the association of [p100] with RelB/p50 dimers in the nucleus , leading to the specific inhibition of RelB DNA binding . Positive_regulation PML EPHB2 18445086 1921204 To our knowledge , this is the first report to show that [PML/RARalpha] was *suppressed* by inhibition , through a mechanism dependent on caspase activation . Positive_regulation PML MAP2K6 18445086 1921210 To our knowledge , this is the first report to show that [PML/RARalpha] was *suppressed* by inhibition , through a mechanism dependent on caspase activation . Positive_regulation PMPCB CCND1 16940298 1627460 Here we show that HBx up-regulates and that this process is *mediated* by the NF-kappaB2 ( [p52] ) /BCL-3 complex . Positive_regulation PMPCB TNF 11238728 790996 Inhibition of *induced* NF-kappaB [p52] converts the metabolic effects of microglial derived TNFalpha on mouse cerebellar neurones to neurotoxicity . Positive_regulation PMPCB TNF 17008396 1674097 However , *induced* a [p52/RelB] NFkappaB DNA binding complex in p50 null MEC nuclear extracts . Positive_regulation PMPCB TNF 17008396 1674107 These data suggest that in wild-type MEC , *stimulates* the interaction of bcl3 with p50 and [p52] , and the binding of p52 , as well as RelB , to cyclin D1 promoter kappaB sites , and as a consequence , stimulates the growth of MEC . Positive_regulation PMPCB TNF 24892805 2946097 *promoted* [p52/RELB] binding to NICD , which enhanced binding at the RBPj? site within the Hes1 promoter . Positive_regulation PMPS CLU 15902848 1409193 [PMPs] were *increased* relative to healthy controls in patients with IC , with a further increase in ( P < 0.001 ) . Positive_regulation PMPS IL1B 11583705 865784 [PMPs] *induced* interleukin-8 (IL-8) , , and tumor necrosis factor alpha (TNF alpha) production by THP-1 . Positive_regulation PMPS IL1B 11583705 865789 [PMPs] also *induced* IL-8 , , and interleukin-6 (IL-6) production by ECs . Positive_regulation PMPS TNF 11583705 865783 [PMPs] *induced* interleukin-8 (IL-8) , interleukin-1 beta (IL-1 beta) , and production by THP-1 . Positive_regulation PMS1 IL1B 15103492 1258352 There was no IL-10 production in *stimulated* adult [PMs] . Positive_regulation PMS1 IL1B 15103492 1258362 Therefore , IL-1beta induces both a pro- and an anti-inflammatory response in pediatric PMs , whereas adult [PMs] produce only pro-inflammatory cytokines in *response* to . Positive_regulation PMS2 IL1B 15103492 1258353 There was no IL-10 production in *stimulated* adult [PMs] . Positive_regulation PMS2 IL1B 15103492 1258363 Therefore , IL-1beta induces both a pro- and an anti-inflammatory response in pediatric PMs , whereas adult [PMs] produce only pro-inflammatory cytokines in *response* to . Positive_regulation PNMA1 MAP2K6 17596563 1792519 The inhibitor , U0126 , and the PKA inhibitors , H89 and cAMP dependent protein kinase peptide inhibitor ( PKI ) , completely *inhibited* [MAPK3/1] activation by either ADCYAP1 or CPT-cAMP . Positive_regulation PNMA2 DAPK1 21311567 2463461 *activates* [MARK1/2] to regulate microtubule assembly , neuronal differentiation , and tau toxicity . Positive_regulation PNMA3 TNF 20463356 2301063 By Western blot analysis , we found that rapidly and significantly *increased* phosphorylation of IKBKB , [MAPK1/3] , and MAPK8/9/10 and that the phosphorylation of these kinases by TNF was reduced significantly by TNFRSF1A neutralizing antibody , but not by TNFRSF1B neutralizing antibody . Positive_regulation PNP NT5E 3011239 59680 The authors have therefore also investigated the changes in enzyme pattern of B-CLL after incubation with TPA B-CLL cells are characterized by low levels of ADA , PNP , and <5'-NT> , but TPA *caused* a marked increase in [PNP] activity ( P less than 0.001 , t test for paired samples ) , a pattern similar to HCL . Positive_regulation PNPLA2 FAS 11927940 927200 The anti-angiogenic activity of thrombospondin-1 and [pigment epithelium derived factor] both in vitro and in vivo was *dependent* on this dual induction of and FasL and the resulting apoptosis . Positive_regulation PNPLA2 FOXO1 22721980 2644098 Cyanidin-3-O-ß-glucoside , a typical anthocyanin , exhibits antilipolytic effects in 3T3-L1 adipocytes during hyperglycemia : involvement of *mediated* transcription of [adipose triglyceride lipase] . Positive_regulation PNPLA3 TNF 19149923 2026725 Plasma [ADPN] levels decreased and plasma levels *increased* in children with obesity and both were main influential factors for % BF in children . Positive_regulation PODXL COL4A1 15226400 1268621 We demonstrated that GBM and laminin , but not , *up-regulated* the expression of [podocalyxin] . Positive_regulation PODXL COL4A2 15226400 1268622 We demonstrated that GBM and laminin , but not , *up-regulated* the expression of [podocalyxin] . Positive_regulation PODXL COL4A3 15226400 1268623 We demonstrated that GBM and laminin , but not , *up-regulated* the expression of [podocalyxin] . Positive_regulation PODXL COL4A4 15226400 1268624 We demonstrated that GBM and laminin , but not , *up-regulated* the expression of [podocalyxin] . Positive_regulation PODXL COL4A5 15226400 1268625 We demonstrated that GBM and laminin , but not , *up-regulated* the expression of [podocalyxin] . Positive_regulation PODXL COL4A6 15226400 1268626 We demonstrated that GBM and laminin , but not , *up-regulated* the expression of [podocalyxin] . Positive_regulation PODXL CSF1 11895768 920770 The M-CSF receptor was expressed in PCLP1 ( + ) CD45 ( - ) cells , the precursors of endothelial cells , and *up-regulated* the expression of more mature endothelial cell markers-VCAM-1 , PECAM-1 , and E-selectin-in [PCLP1] ( + ) CD45 ( - ) cells . Positive_regulation PODXL VDR 23548800 2714194 VDR knockdown abolished the protective action of calcitriol and paricalcitol on podocalyxin expression indicating that [podocalyxin] activation of expression is partly *mediated* by . Positive_regulation PODXL VDR 23548800 2714195 Furthermore , specifically *regulates* [podocalyxin] expression by bounding to a site upstream of the podocalyxin promoter . Positive_regulation PODXL WT1 11719225 883664 *regulates* the expression of the major glomerular podocyte membrane protein [Podocalyxin] . Positive_regulation PODXL WT1 11719225 883666 Here , we show that inducible expression of in rat embryonic kidney cell precursors *leads* to the induction of endogenous [Podocalyxin] , the major structural membrane protein of glomerular podocytes , which is implicated in the maintenance of filtration slits . Positive_regulation PODXL WT1 15155752 1273260 [PODXL] is also transcriptionally *regulated* by and has roles in cell adhesion and anti-adhesion . Positive_regulation POLD3 TNF 18787755 1976072 The low-virulent African swine fever virus ( [ASFV/NH/P68] ) *induces* enhanced expression and production of relevant regulatory cytokines ( IFNalpha , and IL12p40 ) on porcine macrophages in comparison to the highly virulent ASFV/L60 . Positive_regulation POLD3 TP63 18787755 1976073 The low-virulent African swine fever virus ( [ASFV/NH/P68] ) *induces* enhanced expression and production of relevant regulatory cytokines ( IFNalpha , TNFalpha and ) on porcine macrophages in comparison to the highly virulent ASFV/L60 . Positive_regulation POLDIP2 ADRB2 11018034 752783 *induced* [p38] MAPK activation is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes . Positive_regulation POLDIP2 ALOX5 17979994 1845474 At physiologically relevant concentrations , genistein inhibits eosinophil LTC ( 4 ) synthesis in vitro , probably by blocking [p38-] and MAPKAP-2 dependent *activation* of <5-LO> . Positive_regulation POLDIP2 ANGPT1 12213726 985671 To further examine the effects of progestin , hypoxia , and reactive oxygen species ( ROS ) on the regulation of and Ang-2 as well as the *activation* of MAPK , SAPK/JNK , and [p38] by the relevant cell types , we conducted in vitro studies with cultured human endometrial stromal cells ( HESCs ) and human endometrial endothelial cells ( HEECs ) . Positive_regulation POLDIP2 CAPN8 21543591 2424006 Downstream , an Aß-mediated rise in [p38] mitogen activated protein kinase (MAPK) activation was followed by downregulation of cAMP response element binding protein , and LTP impairment was *prevented* by inhibitors of p38 MAPK or . Positive_regulation POLDIP2 CD14 15625444 1349230 LPS interacts with the cell surface receptor , which generates transmembrane signals through Toll-like protein 4 *leading* to mitogen activated protein kinase (MAPK) [p38] activation , cytokine synthesis , PMN beta2-integrin expression and oxidative burst . Positive_regulation POLDIP2 EMP1 21811066 2490384 The [p38] signaling *involves* generation induced by indoxyl sulfate and is effectively suppressed by clopidogrel . Positive_regulation POLDIP2 EPHB2 10872747 707005 Pre-treatment of the cells with PD98059 , a selective pathway inhibitor , and SB203580 , a [p38] MAPK *inhibitor* , blocked the induction of HO-1 by the NO donor in a dose dependent manner . Positive_regulation POLDIP2 EPHB2 11446731 835416 These results indicate that activation of extracellular-signal regulated kinase ( ) is required for TPO induced megakaryocyte differentiation and that [p38] is *required* for TPO induced erythroid differentiation . Positive_regulation POLDIP2 EPHB2 15358225 1293397 A specific inhibitor of JNK , SP600125 , abolished paclitaxel induced HO-1 mRNA expression , whereas PD98059 , a specific inhibitor of , and SB203580 , a specific *inhibitor* of [p38] , had no significant effect . Positive_regulation POLDIP2 EPHB2 15480794 1342486 These alterations in protein level of adhesion molecules and in the phosphorylation of mitogen activated protein kinases by glucose were blocked by inhibition of PKC or [p38] but were synergistically *increased* by the inhibition of . Positive_regulation POLDIP2 EPHB2 16038626 1437387 SF significantly prevented Abeta induced increases in IL-1beta and [p38] MAPK *activation* and also Abeta induced changes in and phospho-Akt/PKB expression levels . Positive_regulation POLDIP2 EPHB2 16418769 1495062 TNFalpha *induced* [p38] and ERK activation , whereas oridonin triggered only activation . Positive_regulation POLDIP2 EPHB2 17464174 1731739 The mRNA and surface protein up-regulation of CCR1 and CCR2 in 9CRA stimulated cells were weakly blocked by the pretreatment of SB202190 , a [p38] MAPK *inhibitor* , and PD98059 , an upstream inhibitor . Positive_regulation POLDIP2 EPHB2 20025124 2175493 Prior treatment of the cells with PD98059 , an kinase inhibitor or SB203580 , a [p38MAPK] *inhibitor* , abrogated the C-peptide elicited JNK1 mRNA expression . Positive_regulation POLDIP2 EPHB2 20054486 2177434 HF6-FC exerts its inhibitory effects by suppression of [p38] and NF-kappaB but *activation* of . Positive_regulation POLDIP2 EPHB2 21586573 2449660 Incubation of T cells with ESAT-6 induced phosphorylation and increased functional [p38] MAPK activity , but not *activation* of or JNK . Positive_regulation POLDIP2 EPHB2 21656160 2494202 TBT *induced* the activation of [p38] and JNK while diesel oil enhanced activation of both and p38 . Positive_regulation POLDIP2 EPHB2 23158946 2700103 Icariin promotes differentiation of the mesenchymal stem cells C3H10T1/2 into osteoblasts , and its effect is related to the restraining of expression and *activation* of [p38] expression in the MAPK signaling pathway . Positive_regulation POLDIP2 EPHB2 24974583 2947616 Treatment of B16F10 cells with U0126 , an inhibitor , or SB203580 , a [p38] *inhibitor* , suppressed the migration and invasion abilities of B16F10 cells . Positive_regulation POLDIP2 FOXO1 17303659 1725977 In contrast , *increases* [p38] activity , and p38 is required for effects of Foxo1 on PKB , at least in part . Positive_regulation POLDIP2 IL1B 10640438 577492 and TNF alpha also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation POLDIP2 IL1B 10903806 713234 We conclude that *induces* activation of both [p38] and ERK1/2 , and that ERK1/2 contributes to the pro-apoptotic effects of the cytokine in primary beta-cells . Positive_regulation POLDIP2 IL1B 12091394 984416 Apoptotic changes in the aged brain are triggered by *induced* activation of [p38] and reversed by treatment with eicosapentaenoic acid . Positive_regulation POLDIP2 IL1B 12649265 1079999 *induced* the phosphorylation of p38alpha and [p38beta2] MAPK in cardiomyocytes and stimulated RNA polymerase II binding to the COX-2 promoter , COX-2 transcription , COX-2 protein synthesis , and prostaglandin E2 ( PGE2 ) release . Positive_regulation POLDIP2 IL1B 12649265 1080061 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant MKK6 or p38beta2 MAPK inhibited *induced* [p38] MAPK activation , COX-2 gene expression , and PGE2 release . Positive_regulation POLDIP2 IL1B 12727980 1086592 The altered property of decidualized cells is thought to be caused by attenuation of *induced* [p38] MAPK phosphorylation in a way that involves the activation of the cAMP/protein kinase A pathway . Positive_regulation POLDIP2 IL1B 12799462 1101010 Compound 4a inhibited *induced* phosphorylation of the mitogen activated protein kinase [p38] in EL4 thymoma cells and in freshly isolated murine lymphocytes in a concentration dependent manner . Positive_regulation POLDIP2 IL1B 16141635 1454863 DHA stimulated both rapid and prolonged activation of p44/42 , but not [p38] , mitogen activated protein kinase (MAPK) *induced* by and PMA . Positive_regulation POLDIP2 IL1B 16959849 1639691 *caused* an increase in the phosphorylation of ERK , but not [p38MAPK] or c-Jun N-terminal kinase . Positive_regulation POLDIP2 IL1B 17920534 1804181 SA981 at a concentration of 100 microM partially inhibited *induced* phosphorylation of [p38MAPK] and Akt ( 12.0 % and 36.1 % inhibition of each total amount of phosphoprotein under IL-1beta coexistence condition , respectively ) . Positive_regulation POLDIP2 IL1B 19214751 2071847 *triggered* the activation of [p38] and ERK1/2 ( p44/42) MAP kinase (MAPK) signaling pathways , but WIN55,212-2 mainly inhibited p38 MAPK phosphorylation . Positive_regulation POLDIP2 IL1B 19229069 2054619 Neutralization of the IL-8 receptor , CXCR2 , further induced VCAM-1 in the *presence* of , and [phospho-p38] was required for NF-kappaB activation and VCAM-1 expression . Positive_regulation POLDIP2 LBP 11134043 794922 Here we show that secretion of tumor necrosis factor-alpha induced by Treponema culture supernatants and extracted LTA was paralleled by an *dependent* phosphorylation of mitogen activated protein kinases ( MAPKs ) p42 and p44 , and [p38] , as well as the stress activated protein kinases c-Jun N-terminal kinases 1 and 2 . Positive_regulation POLDIP2 MAP2K6 10627526 659113 Using vectors which express dominant negative proteins , we demonstrate that basal kinase activity is *necessary* for HCMV mediated [p38] activation at these early times of infection ( 12 hpi ) . Positive_regulation POLDIP2 MAP2K6 10903976 713449 PD098059 , a mitogen activated and extracellular regulated kinase kinase ( MEK) 1 inhibitor , UO126 , a dual MEK1 <& MEK2> inhibitor , and SB203580 , a [p38] MAP kinase *inhibitor* in the IL-1beta dependent release of PGE ( 2 ) . Positive_regulation POLDIP2 MAP2K6 12589052 1059820 Transforming growth factor-beta1 ( TGF-beta ) -induced apoptosis of prostate cancer cells involves Smad7 dependent *activation* of [p38] by TGF-beta activated kinase 1 and 3 . Positive_regulation POLDIP2 MAP2K6 15790570 1410264 Expression of *activated* [p38] and resulted in phosphorylation of its downstream substrate , heat shock protein 27 (Hsp27) . Positive_regulation POLDIP2 MAP2K6 20004242 2199797 In this study , we examined [p38beta] , gamma and delta *activation* by MKK3 and , in cells lacking MKK3 , MKK6 or both . Positive_regulation POLDIP2 MAP2K6 20004242 2199799 We show that MKK3 and MKK6 are both essential for the activation of p38gamma and p38beta induced by environmental stress , whereas is the major [p38gamma] *activator* in response to TNFalpha . Positive_regulation POLDIP2 MAP2K6 23867467 2835236 The intracisternal administration of PD98059 ( 1 , 10µg ) , a inhibitor , and SB203580 ( 1 , 5µg ) , a [p38] *inhibitor* , also attenuated the number of formalin induced scratches in the second phase in the IL-1ß treated rats . Positive_regulation POLDIP2 MAP2K6 8622669 354461 Expression of activated MKK3 and in cultured cells *caused* a selective increase in [p38] MAP kinase activity . Positive_regulation POLDIP2 PLAT 23562854 2777998 Glucose deprivation induced activation of PI3K-Akt-GSK3ß , [p38] and AMPK , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation POLDIP2 SELL 9415029 471871 In the present study we demonstrate that stimulation of Jurkat T lymphocytes via *results* in an activation of Jun N-terminal kinase (JNK) but not of [p38-K] . Positive_regulation POLDIP2 TNF 10604552 575042 The results showed that *induced* RANTES production and [p38] MAP kinase activity in human pulmonary vascular endothelial cells . Positive_regulation POLDIP2 TNF 10640438 577491 IL-1 beta and also *stimulated* [p38-MAPK] phosphorylation , but the response to IL-1 beta was consistently greater than TNF alpha . Positive_regulation POLDIP2 TNF 10843427 700084 These results indicated that induced [p38] MAP kinase *activation* and p38 MAP kinase mediated RANTES production by human pulmonary vascular endothelial cells are inversely regulated by intracellular GSH levels . Positive_regulation POLDIP2 TNF 11156586 780635 6. These results indicate that the cellular reduction and oxidation ( redox ) regulated by intracellular GSH is critical for *induced* activation of p38 MAP kinase pathway and [p38] MAP kinase mediated IL-8 production by human pulmonary vascular endothelial cells , and we emphasize that anti-oxidant therapy is an important strategy for the treatment of acute lung injury . Positive_regulation POLDIP2 TNF 11167962 783080 These results indicate that cellular redox regulated by GSH is critical for induced [p38] MAP kinase *activation* and p38 MAP kinase mediated RANTES production by human BECs . Positive_regulation POLDIP2 TNF 12114204 963989 *increased* the phosphorylation of p38 MAPK within 15 min. Anisomycin , an activator of p38 MAPK , increased [p38] MAPK phosphorylation and decreased SP-A mRNA levels in a dose dependent manner . Positive_regulation POLDIP2 TNF 12634851 1068391 Consistent with recent reports demonstrating the antagonistic actions of NF-kappaB and c-Jun amino-terminal kinase (JNK) signalling , we have found that Par4 ( -/- ) cells show a reduced activation of the sustained phase of JNK and [p38] *stimulation* by and interleukin 1 . Positive_regulation POLDIP2 TNF 12867430 1142100 Taken together , our results suggest that *induced* [p38] MAPK activation may regulate the induction of functionally active HA-binding form of CD44 by activating sialidase in LPS stimulated human monocytic cells . Positive_regulation POLDIP2 TNF 14566965 1155098 In both prechondrocytes and articular chondrocytes , *induced* concentration dependent activation of MEK1/2 and NF-kappaB , but not [p38] or JNK . Positive_regulation POLDIP2 TNF 14720501 1197828 Extracellular signal regulated kinase ( ERK1/2 ) , c-Jun N-terminal kinase (JNK) and [p38] were rapidly and significantly *activated* by in HUVEC . Positive_regulation POLDIP2 TNF 15087472 1258130 Stimulatory effects of on neuropeptide gene expression and release appeared to be mediated through the type 2 TNF-alpha receptor , and *required* activation of ERK 1/2 and [p38] , but not Janus kinase , MAPKs . Positive_regulation POLDIP2 TNF 15240725 1270465 Finally , [p38] MAPK *activation* by was blocked by diphenylene iodonium , an inhibitor of flavoprotein oxidoreductase , and by the free radical scavenger N-acetylcystein . Positive_regulation POLDIP2 TNF 15365619 1334204 Rosiglitazone ameliorates insulin resistance in brown adipocytes of Wistar rats by impairing *induction* of [p38] and p42/p44 mitogen activated protein kinases . Positive_regulation POLDIP2 TNF 15454113 1301136 PA and *increased* the phosphorylation of extracellular signal regulated kinase ( ERK)-1/2 , [p38-kinase] , and c-Jun N-terminal kinase (JNK) by Western blotting . Positive_regulation POLDIP2 TNF 16291755 1510579 *stimulates* the JNK , ERK , and [p38] mitogen activated protein kinases and the NF-kappaB pathway by recruiting RIP1 and TRAF2 to the TNF receptor 1 . Positive_regulation POLDIP2 TNF 16418769 1495061 *induced* [p38] and ERK activation , whereas oridonin triggered only ERK activation . Positive_regulation POLDIP2 TNF 16813528 1580730 In addition , activation of p38 was blocked in rats treated with TNF-alpha antagonist , suggesting a *role* of in [p38] activation . Positive_regulation POLDIP2 TNF 17161959 1694532 Upon examination of the signaling components , we found that was a potent *activator* of [p38] , p44/42 , p54/46 MAPK , and IkappaBalpha ( IkappaBalpha ) . Positive_regulation POLDIP2 TNF 17189827 1680125 Stimulation of cells with *resulted* in the activation of mitogen activated protein kinases (MAPK) such as c-Jun N-terminal kinase (JNK) and [p38] , and the abrogation by pretreatment with JNK or p38 MAPK inhibitor . Positive_regulation POLDIP2 TNF 17446186 1749500 *increased* [p38] MAPK phosphorylation , potently stimulated IRS-1 serine phosphorylation , and blunted insulin stimulated IRS-1 tyrosine and Akt phosphorylation and eNOS activity . Positive_regulation POLDIP2 TNF 18042890 1828837 Conversely phosphorylated [p38] ( p-p38 ) could *induce* the upregulation of . Positive_regulation POLDIP2 TNF 18557926 1984197 In this work , we demonstrate that in the premalignant keratinocyte cell line HaCaT , *activates* Akt , ERK1/2 and [p38] . Positive_regulation POLDIP2 TNF 19410630 2089688 By transfection of TAK1 siRNA , *induced* phosphorylation of IkappaBalpha , JNK1/2 , and [p38MAPK] , as well as IL-6 or IL-8 expression , were repressed . Positive_regulation POLDIP2 TNF 19850966 2170300 Both and ET-1 *activated* [p38] ( MAPK ) and extracellular signal regulated kinase ( ERK ) -1/-2 signalling . Positive_regulation POLDIP2 TNF 20004242 2199798 We show that MKK3 and MKK6 are both essential for the activation of p38gamma and p38beta induced by environmental stress , whereas MKK6 is the major [p38gamma] activator in *response* to . Positive_regulation POLDIP2 TNF 20663875 2317008 Analyses of intracellular signaling revealed that the IL-1 and induced *activation* of JNK , [p38] , and NF-?B pathways was impaired in Ubc13 ( flox/flox ) K5-Cre keratinocytes . Positive_regulation POLDIP2 TNF 22294037 2586300 Thus , nocodazole increases the ERK activity to enhance MKP-1 expression which inhibits [p38] activation *induced* by . Positive_regulation POLDIP2 TNF 22947346 2678655 *induced* phosphorylated [p38] mitogen activated protein kinase levels were increased in ASMCs from patients with severe asthma compared with those from patients with nonsevere asthma and nonasthmatic subjects , whereas TNF-a induced phosphorylated c-Jun N-terminal kinase and phosphorylated extracellular signal related kinase levels were increased in all asthmatic groups . Positive_regulation POLDIP2 TNF 9379049 465840 In this study , we have investigated the mechanism of *activation* of the [p38mapk] by in mouse bone marrow derived macrophages . Positive_regulation POLDIP2 TNF 9916130 587461 However , [p38] kinase *activation* by mannitol or was not inhibited by GF109203X . Positive_regulation POLDIP2 TNFSF10 19895579 2176168 Although *induced* stimulation of c-Jun N-terminal kinase and [p38] was caspase dependent in a cell type-specific fashion , activation of nuclear factor kappaB and p42/44 was caspase independent in all cases . Positive_regulation POLDIP2 TNFSF10 21152872 2373382 We found that MEKK1/MEKK4 as opposed to ASK1 , are responsible for *induced* c-Jun NH2-terminal kinase (JNK) or [p38] activation , and that their catalytic activity is repressed by the caspase-8 inhibitor , suggesting that the caspase-8 activation induced by TRAIL is indispensible for MEKK activation . Positive_regulation POLDIP2 TNFSF10 23456625 2787400 Collectively , our data suggest in a subset of NSCLC cells a model in which *induced* activation of [p38] and JNK have counteracting effects on Mcl-1 expression leading to pro- or anti-apoptotic effects , respectively . Positive_regulation POLDIP3 IL1B 12507586 1038431 Also , but not EGCG , *induced* the expression of JNK [p46] without modulating the expression of JNK p54 in OA chondrocytes . Positive_regulation POLDIP3 TNF 9371818 466184 In addition , both the [p46] and p54 JNK/SAPK isoforms were phosphorylated on their TPY motif in *response* to stimulation as reflected by immunoblotting with a phospho-specific antibody that recognizes both kinases . Positive_regulation POLI EPHB2 21555369 2440857 Finally , ErbB2 potentiated RNA [Pol I] transcription could be stimulated by ligand and was not substantially *repressed* by inhibition of PI3-K and ( extracellular signal regulated kinase ) , the main ErbB2 effector signaling pathways . Positive_regulation POLI MAP2K6 21555369 2440863 Finally , ErbB2 potentiated RNA [Pol I] transcription could be stimulated by ligand and was not substantially *repressed* by inhibition of PI3-K and ( extracellular signal regulated kinase ) , the main ErbB2 effector signaling pathways . Positive_regulation POLR2A EDN2 12368904 998456 A preferential role for Cdk9 was shown in [RNA polymerase II] phosphorylation and growth *induced* by , using pharmacological and dominant negative inhibitors . Positive_regulation POLR2A IL1B 12649265 1080007 induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and *stimulated* [RNA polymerase II] binding to the COX-2 promoter , COX-2 transcription , COX-2 protein synthesis , and prostaglandin E2 ( PGE2 ) release . Positive_regulation POLR2A TNF 12192035 980755 Here we report that even though NF-kappaB interacts directly with TAF(II)s , induction of NF-kappaB by does not *enhance* TFIID recruitment and [preinitiation complex] formation on some NF-kappaB-responsive promoters . Positive_regulation POLR2A TNF 18688044 1961011 *induced* inflammatory gene expression , H3K4me2 levels , and recruitment of [RNA polymerase II] at the gene promoters were also enhanced in db/db VSMCs , demonstrating the formation of open chromatin poised for transcriptional activation in diabetes . Positive_regulation POLR2A TNF 19734226 2139670 Furthermore , chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and [RNA polymerase II] to the CXCL8 promoter of asthmatic HASM cells both in the *presence* and absence of stimulation . Positive_regulation POLR2B EDN2 12368904 998459 A preferential role for Cdk9 was shown in [RNA polymerase II] phosphorylation and growth *induced* by , using pharmacological and dominant negative inhibitors . Positive_regulation POLR2B IL1B 12649265 1080008 induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and *stimulated* [RNA polymerase II] binding to the COX-2 promoter , COX-2 transcription , COX-2 protein synthesis , and prostaglandin E2 ( PGE2 ) release . Positive_regulation POLR2B TNF 18688044 1961012 *induced* inflammatory gene expression , H3K4me2 levels , and recruitment of [RNA polymerase II] at the gene promoters were also enhanced in db/db VSMCs , demonstrating the formation of open chromatin poised for transcriptional activation in diabetes . Positive_regulation POLR2B TNF 19734226 2139671 Furthermore , chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and [RNA polymerase II] to the CXCL8 promoter of asthmatic HASM cells both in the *presence* and absence of stimulation . Positive_regulation POLR2C EDN2 12368904 998462 A preferential role for Cdk9 was shown in [RNA polymerase II] phosphorylation and growth *induced* by , using pharmacological and dominant negative inhibitors . Positive_regulation POLR2C IL1B 12649265 1080009 induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and *stimulated* [RNA polymerase II] binding to the COX-2 promoter , COX-2 transcription , COX-2 protein synthesis , and prostaglandin E2 ( PGE2 ) release . Positive_regulation POLR2C TNF 18688044 1961013 *induced* inflammatory gene expression , H3K4me2 levels , and recruitment of [RNA polymerase II] at the gene promoters were also enhanced in db/db VSMCs , demonstrating the formation of open chromatin poised for transcriptional activation in diabetes . Positive_regulation POLR2C TNF 19734226 2139672 Furthermore , chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and [RNA polymerase II] to the CXCL8 promoter of asthmatic HASM cells both in the *presence* and absence of stimulation . Positive_regulation POLR2D EDN2 12368904 998465 A preferential role for Cdk9 was shown in [RNA polymerase II] phosphorylation and growth *induced* by , using pharmacological and dominant negative inhibitors . Positive_regulation POLR2D IL1B 12649265 1080010 induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and *stimulated* [RNA polymerase II] binding to the COX-2 promoter , COX-2 transcription , COX-2 protein synthesis , and prostaglandin E2 ( PGE2 ) release . Positive_regulation POLR2D TNF 18688044 1961014 *induced* inflammatory gene expression , H3K4me2 levels , and recruitment of [RNA polymerase II] at the gene promoters were also enhanced in db/db VSMCs , demonstrating the formation of open chromatin poised for transcriptional activation in diabetes . Positive_regulation POLR2D TNF 19734226 2139673 Furthermore , chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and [RNA polymerase II] to the CXCL8 promoter of asthmatic HASM cells both in the *presence* and absence of stimulation . Positive_regulation POLR2E EDN2 12368904 998468 A preferential role for Cdk9 was shown in [RNA polymerase II] phosphorylation and growth *induced* by , using pharmacological and dominant negative inhibitors . Positive_regulation POLR2E IL1B 12649265 1080011 induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and *stimulated* [RNA polymerase II] binding to the COX-2 promoter , COX-2 transcription , COX-2 protein synthesis , and prostaglandin E2 ( PGE2 ) release . Positive_regulation POLR2E TNF 18688044 1961015 *induced* inflammatory gene expression , H3K4me2 levels , and recruitment of [RNA polymerase II] at the gene promoters were also enhanced in db/db VSMCs , demonstrating the formation of open chromatin poised for transcriptional activation in diabetes . Positive_regulation POLR2E TNF 19734226 2139674 Furthermore , chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and [RNA polymerase II] to the CXCL8 promoter of asthmatic HASM cells both in the *presence* and absence of stimulation . Positive_regulation POLR2F EDN2 12368904 998471 A preferential role for Cdk9 was shown in [RNA polymerase II] phosphorylation and growth *induced* by , using pharmacological and dominant negative inhibitors . Positive_regulation POLR2F IL1B 12649265 1080012 induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and *stimulated* [RNA polymerase II] binding to the COX-2 promoter , COX-2 transcription , COX-2 protein synthesis , and prostaglandin E2 ( PGE2 ) release . Positive_regulation POLR2F TNF 18688044 1961016 *induced* inflammatory gene expression , H3K4me2 levels , and recruitment of [RNA polymerase II] at the gene promoters were also enhanced in db/db VSMCs , demonstrating the formation of open chromatin poised for transcriptional activation in diabetes . Positive_regulation POLR2F TNF 19734226 2139675 Furthermore , chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and [RNA polymerase II] to the CXCL8 promoter of asthmatic HASM cells both in the *presence* and absence of stimulation . Positive_regulation POLR2G EDN2 12368904 998474 A preferential role for Cdk9 was shown in [RNA polymerase II] phosphorylation and growth *induced* by , using pharmacological and dominant negative inhibitors . Positive_regulation POLR2G IL1B 12649265 1080013 induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and *stimulated* [RNA polymerase II] binding to the COX-2 promoter , COX-2 transcription , COX-2 protein synthesis , and prostaglandin E2 ( PGE2 ) release . Positive_regulation POLR2G TNF 18688044 1961017 *induced* inflammatory gene expression , H3K4me2 levels , and recruitment of [RNA polymerase II] at the gene promoters were also enhanced in db/db VSMCs , demonstrating the formation of open chromatin poised for transcriptional activation in diabetes . Positive_regulation POLR2G TNF 19734226 2139676 Furthermore , chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and [RNA polymerase II] to the CXCL8 promoter of asthmatic HASM cells both in the *presence* and absence of stimulation . Positive_regulation POLR2H EDN2 12368904 998477 A preferential role for Cdk9 was shown in [RNA polymerase II] phosphorylation and growth *induced* by , using pharmacological and dominant negative inhibitors . Positive_regulation POLR2H IL1B 12649265 1080014 induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and *stimulated* [RNA polymerase II] binding to the COX-2 promoter , COX-2 transcription , COX-2 protein synthesis , and prostaglandin E2 ( PGE2 ) release . Positive_regulation POLR2H TNF 18688044 1961018 *induced* inflammatory gene expression , H3K4me2 levels , and recruitment of [RNA polymerase II] at the gene promoters were also enhanced in db/db VSMCs , demonstrating the formation of open chromatin poised for transcriptional activation in diabetes . Positive_regulation POLR2H TNF 19734226 2139677 Furthermore , chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and [RNA polymerase II] to the CXCL8 promoter of asthmatic HASM cells both in the *presence* and absence of stimulation . Positive_regulation POLR2I EDN2 12368904 998480 A preferential role for Cdk9 was shown in [RNA polymerase II] phosphorylation and growth *induced* by , using pharmacological and dominant negative inhibitors . Positive_regulation POLR2I IL1B 12649265 1080015 induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and *stimulated* [RNA polymerase II] binding to the COX-2 promoter , COX-2 transcription , COX-2 protein synthesis , and prostaglandin E2 ( PGE2 ) release . Positive_regulation POLR2I TNF 18688044 1961019 *induced* inflammatory gene expression , H3K4me2 levels , and recruitment of [RNA polymerase II] at the gene promoters were also enhanced in db/db VSMCs , demonstrating the formation of open chromatin poised for transcriptional activation in diabetes . Positive_regulation POLR2I TNF 19734226 2139678 Furthermore , chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and [RNA polymerase II] to the CXCL8 promoter of asthmatic HASM cells both in the *presence* and absence of stimulation . Positive_regulation POLR2J EDN2 12368904 998483 A preferential role for Cdk9 was shown in [RNA polymerase II] phosphorylation and growth *induced* by , using pharmacological and dominant negative inhibitors . Positive_regulation POLR2J IL1B 12649265 1080016 induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and *stimulated* [RNA polymerase II] binding to the COX-2 promoter , COX-2 transcription , COX-2 protein synthesis , and prostaglandin E2 ( PGE2 ) release . Positive_regulation POLR2J TNF 18688044 1961020 *induced* inflammatory gene expression , H3K4me2 levels , and recruitment of [RNA polymerase II] at the gene promoters were also enhanced in db/db VSMCs , demonstrating the formation of open chromatin poised for transcriptional activation in diabetes . Positive_regulation POLR2J TNF 19734226 2139679 Furthermore , chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and [RNA polymerase II] to the CXCL8 promoter of asthmatic HASM cells both in the *presence* and absence of stimulation . Positive_regulation POLR2K EDN2 12368904 998486 A preferential role for Cdk9 was shown in [RNA polymerase II] phosphorylation and growth *induced* by , using pharmacological and dominant negative inhibitors . Positive_regulation POLR2K IL1B 12649265 1080017 induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and *stimulated* [RNA polymerase II] binding to the COX-2 promoter , COX-2 transcription , COX-2 protein synthesis , and prostaglandin E2 ( PGE2 ) release . Positive_regulation POLR2K TNF 18688044 1961021 *induced* inflammatory gene expression , H3K4me2 levels , and recruitment of [RNA polymerase II] at the gene promoters were also enhanced in db/db VSMCs , demonstrating the formation of open chromatin poised for transcriptional activation in diabetes . Positive_regulation POLR2K TNF 19734226 2139680 Furthermore , chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and [RNA polymerase II] to the CXCL8 promoter of asthmatic HASM cells both in the *presence* and absence of stimulation . Positive_regulation POLR2L EDN2 12368904 998489 A preferential role for Cdk9 was shown in [RNA polymerase II] phosphorylation and growth *induced* by , using pharmacological and dominant negative inhibitors . Positive_regulation POLR2L IL1B 12649265 1080018 induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and *stimulated* [RNA polymerase II] binding to the COX-2 promoter , COX-2 transcription , COX-2 protein synthesis , and prostaglandin E2 ( PGE2 ) release . Positive_regulation POLR2L TNF 18688044 1961022 *induced* inflammatory gene expression , H3K4me2 levels , and recruitment of [RNA polymerase II] at the gene promoters were also enhanced in db/db VSMCs , demonstrating the formation of open chromatin poised for transcriptional activation in diabetes . Positive_regulation POLR2L TNF 19734226 2139681 Furthermore , chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and [RNA polymerase II] to the CXCL8 promoter of asthmatic HASM cells both in the *presence* and absence of stimulation . Positive_regulation POM121 NES 9371762 466113 A functional is *required* for active export , presumably by interacting directly or indirectly with the [nuclear pore complex] . Positive_regulation POMC FOXO1 24773342 2944472 In that study , central inhibition of Sirt1 decreased body weight and food intake as a result of a *mediated* increase in the anorexigenic [proopiomelanocortin (POMC)] and decrease in the orexigenic Agouti related peptide in the hypothalamic arcuate nucleus . Positive_regulation POMC FOXO1 24773342 2944474 Elevated acetylated and phosphorylated FoxO1 *increased* [POMC] along with the a-MSH maturation enzyme carboxypeptidase E , which resulted in more of the bioactive POMC product a-MSH released into the paraventricular nucleus . Positive_regulation PON1 CLU 9109446 424851 On an atherogenic diet , [PON] activity decreased by 52 % , and levels *increased* 2.8-fold in fatty streak susceptible mice , C57BL/6J ( BL/6 ) , but not in fatty streak resistant mice , C3H/HeJ ( C3H ) . Positive_regulation PON1 MAP2K6 22155455 2542723 uPA downregulated [PON1] gene expression via inactivation of peroxisome proliferator activated receptor-? ( PPAR? ) activity , and this effect was *dependent* on uPA mediated activation . Positive_regulation PON1 PLAU 22155455 2542725 uPA downregulated [PON1] gene expression via inactivation of peroxisome proliferator activated receptor-? ( PPAR? ) activity , and this effect was *dependent* on mediated mitogen activated protein kinase kinase activation . Positive_regulation PON1 TNF 23791833 2815417 The results showed that IL-6 , but not and IL-1ß , significantly *increased* both the function and protein level of [PON1] ; Positive_regulation PON1 TNF 9712337 527247 Additionally , and IL-1 treatment of HepG2 cells *results* in a decrease in [PON] mRNA levels indicating that these cytokines are capable of directly affecting liver cells . Positive_regulation PON2 PLAU 18436804 1926421 *upregulates* [paraoxonase 2] expression in macrophages via an NADPH oxidase dependent mechanism . Positive_regulation PON2 PLAU 18436804 1926423 *increased* [PON2] expression in THP-1 macrophages in a dose dependent manner . Positive_regulation PON2 PLAU 19497963 2128442 We have recently shown that *increases* oxidative stress ( OS ) , cholesterol biosynthesis , and [paraoxonase 2 (PON2)] expression in macrophages via binding to its receptor , the uPAR . Positive_regulation PON2 PLAU 19497963 2128443 The increase in macrophage [PON2] mRNA levels in *response* to was shown to depend on PON2 gene promoter activation and mRNA transcription . Positive_regulation POSTN CTGF 19433344 2128253 Our studies documented that and FGF2 significantly *enhanced* the expression of collagens I & III , biglycan and [periostin] in tissue engineered regenerates after 4 weeks compared to untreated controls . Positive_regulation POSTN EPHB2 19661231 2186106 The IL-4 stimulated [periostin] induction was *suppressed* by MAP kinase 1 inhibitor , indicating an involvement of the MAP kinase pathway . Positive_regulation POT1 EPHB2 12402047 1009416 We conclude that cAMP induced regulation of and *activation* of [Rap1] are independent processes . Positive_regulation POT1 F2R 15078882 1251920 Concomitant stimulation of both and PAR-4 in the presence of ADP scavengers still *resulted* in a strongly reduced activation of [Rap1B] . Positive_regulation POT1 FLG 17045653 1666570 Using a Rap1-GTP pull-down assay , we found that stimulation , but not LPS , of avian heterophils *induced* a rapid and transient [Rap1] activation . Positive_regulation POT1 FLG 17045653 1666591 We show here that stimulation of heterophils *induces* the phosphorylation of [Rap1] . Positive_regulation POT1 ITGAL 24486015 2928144 The gap junction protein connexin43 (Cx43) regulates B lymphocyte adhesion , BCR- and mediated *activation* of the GTPase [Rap1] , and cytoskeletal rearrangements resulting in changes to cell shape and membrane spreading . Positive_regulation POT1 PECAM1 10725328 677540 Importantly , selectively *activated* the small Ras related GTPase , [Rap1] , but not Ras , R-Ras , or Rap2 . Positive_regulation POU1F1 TNF 20817733 2336415 Interestingly , [PiT1] transcription has been shown to be *up-regulated* by the , and we have now investigated the possible involvement of PiT1 in TNF induced apoptosis . Positive_regulation POU2AF1 ADRB2 15024018 1243889 stimulation *increased* CREB phosphorylation , OCA-B expression , and [OCA-B] binding to the 3'-IgH enhancer in a protein kinase A-dependent manner , an effect lost when beta2-adrenergic receptor-deficient B cells were used . Positive_regulation POU5F1 ABCG2 20683952 2299084 We further demonstrate that [Oct4] overexpression induced activation of TCL1 , AKT , and to *mediate* chemoresistance , which can be overcome by addition of the PI3K/AKT inhibitor ; Positive_regulation POU5F1 ZFP57 18687992 1984756 This interaction is important because [Oct4] binding to the Nanog promoter is *promoted* by . Positive_regulation POU6F1 MAOA 22850464 2757210 The enzymatic degradation of [brain 5-HT] is mainly *mediated* by and , in the absence of this enzyme , by its cognate isoenzyme MAOB . Positive_regulation PPA1 AXIN2 21814488 2462847 Third , [Ppa-LIN-18/Ryk] signaling *involves* and ß-catenin and Ppa-axl-1/Axin is epistatic to Ppa-lin-18/Ryk . Positive_regulation PPA2 AXIN2 21814488 2462841 Third , [Ppa-LIN-18/Ryk] signaling *involves* and ß-catenin and Ppa-axl-1/Axin is epistatic to Ppa-lin-18/Ryk . Positive_regulation PPARA ALDH2 12604186 1062570 Recently , we have shown that enrichment of a highly deviated rat hepatoma cell line , JM2 , with arachidonic acid , a natural ligand of peroxisome proliferator activated receptors ( PPARs ) , inhibits growth , partially restores and ALDH3 to their normal levels and *induces* [PPAR] expression . Positive_regulation PPARA ALOX5 20400503 2282138 Subsequent studies show both in vitro and in a murine model of inflammation that <5-lipoxygenase> stimulation *induces* [PPAR-alpha] signaling and that this results specifically from production of the inflammatory mediator and chemoattractant leukotriene B ( 4 ) ( LTB ( 4 ) ) . Positive_regulation PPARA EPHB2 15149321 1248370 activity positively *regulated* [PPAR] activation . Positive_regulation PPARA FAS 23365010 2738899 This indicates that the binding of CLAs and their precursor to PPAR subtypes *results* in [PPAR] activation , thereby induction of the target transporter genes coupled with downstream lipid metabolising genes such as ACOX-1 and PBE . Positive_regulation PPARA FAS 9558724 500196 However , the potent PPAR activators ETYA and Wy-14643 did not suppress hepatic expression of , but did *induce* the [PPAR-responsive] gene , acyl-CoA oxidase (AOX) . Positive_regulation PPARA PGC 10669761 666581 also *enhanced* the transactivation activity of a [PPARalpha-Gal4] DNA binding domain fusion protein . Positive_regulation PPARA PGC 10669761 666583 Retroviral vector mediated expression studies performed in 3T3-L1 cells demonstrated that PPARalpha and cooperatively *induced* the expression of [PPARalpha] target genes and increased cellular palmitate oxidation rates . Positive_regulation PPARA PGC 19577662 2136772 We also performed in vitro transfection assays to obtain mechanistic knowledge of how TTA affected [PPAR] activation in the *presence* of and steroid receptor coactivators (SRC)-1 and SRC-2 , which are associated with energy balance and mitochondrial biogenesis . Positive_regulation PPARA TP63 19458633 2128291 Distinct [PPARalpha] transcripts are differentially *regulated* by , indicating a bimodal action in promoter and/or transcription start specification . Positive_regulation PPARD EPHB2 10969080 744895 These results suggest that p38 , but not , activation is *required* for induced Cox-2 and [PPARdelta] expression during decidualization . Positive_regulation PPARD HBEGF 17637826 1842247 [PPARdelta] enhances keratinocyte proliferation in psoriasis and *induces* . Positive_regulation PPARD TNF 18095554 1838246 To explore the effect of epidermal growth factor (EGF) on apoptosis *induced* by and the expression of [PPARbeta] in HaCaT keratinocytes . Positive_regulation PPARG ALOX5 11511519 851065 Additional experiments suggest that this involves the interplay of several factors , including the loss of growth stimulation by <5-LO> products , the *induction* of [PPARg] , and the potential activation of PPARg by interactions with shunted endoperoxides . Positive_regulation PPARG ARSA 15824083 1397511 In epithelial cells , <5-ASA> *increased* [PPAR-gamma] expression , promoted its translocation from the cytoplasm to the nucleus , and induced a modification of its conformation permitting the recruitment of coactivators and the activation of a peroxisome-proliferator response element-driven gene . Positive_regulation PPARG CTGF 16723090 1565396 [PPAR gamma] inhibits growth of rat hepatic stellate cells and TGF beta *induced* expression . Positive_regulation PPARG EPHB2 12475986 1056004 In addition , TGZ induces *dependent* phosphorylation of [PPAR gamma] , resulting in the down-regulation of PPAR gamma activity . Positive_regulation PPARG EPHB2 15149321 1248368 The *role* of and phosphorylation in [PPAR gamma] activation were studied , as were the effects of PPAR agonists on ERK activation and cell proliferation . Positive_regulation PPARG EPHB2 15193259 1259556 Inhibition of HER-kinase activation prevents *mediated* degradation of [PPARgamma] . Positive_regulation PPARG EPHB2 16945329 1615524 Pretreatment with bisindolylmaleimide I or NAC blocked TPA induced phosphorylation of extracellular signal regulated kinase ( ERK ) , suggesting that mediated signaling is also *involved* in the induction of [PPARgamma] . Positive_regulation PPARG EPHB2 19243475 2271826 Serum regulates adipogenesis of mesenchymal stem cells via *dependent* [PPARgamma] expression and phosphorylation . Positive_regulation PPARG EPHB2 23058985 2698656 Beta-D-glucoside protects against advanced glycation end products ( AGEs ) -mediated diabetic responses by suppressing and *inducing* [PPAR gamma] DNA binding . Positive_regulation PPARG JAG1 12107827 963114 mediated activation of notch signaling *induces* complete maturation of human keratinocytes through NF-kappaB and [PPARgamma] . Positive_regulation PPARG MAP2K6 19243475 2271832 Serum regulates adipogenesis of mesenchymal stem cells via *dependent* [PPARgamma] expression and phosphorylation . Positive_regulation PPARG PGC 10393183 627156 binds to and *increases* the transcriptional activity of [PPARgamma] but does not interact with other PPARs or most other nuclear receptors . Positive_regulation PPARG PGC 9529258 496601 greatly *increases* the transcriptional activity of [PPARgamma] and the thyroid hormone receptor on the uncoupling protein ( UCP-1 ) promoter . Positive_regulation PPARG SLC38A3 16574647 1562432 *induced* degradation of [PPARgamma] appeared to be mediated through phosphorylation of PPARgamma at serine 84 by a process involving the biphasic phosphorylation of ERK1/2 and activation of the epidermal growth factor receptor (EGFR) . Positive_regulation PPARG TNF 18155667 1862694 The [PPARgamma] and LXRalpha mRNA were also significantly *induced* by 10 ng/ml and down regulated by higher TNF-alpha concentration . Positive_regulation PPARG TNF 18155667 1862695 After pre treated by GW9662 , the expression of [PPARgamma] *induced* by was partially prevented , subsequent to the down-regulation of LXRalpha and ABCA1 . Positive_regulation PPARG TNF 18655773 1947858 [PPARgamma] activity is *regulated* by at pre-translational and post-translational levels . Positive_regulation PPARG TNF 20404035 2246081 also *induced* Cd36 and peroxisome proliferators activated receptor ( [Ppar)gamma] expression , as well as microsomal triglyceride transfer protein ( Mtp ) protein and mRNA , but suppressed the sterol regulatory element binding protein ( Srebp)1c protein and mRNA level . Positive_regulation PPARG TNF 22911724 2648580 Using a non-adipogenic HEK293 cell line transfected with luciferase reporter genes , we demonstrated that BME reduced basal and *induced* NFkappaB activity and increased basal and ciglitazone induced [PPARgamma] activity ; Positive_regulation PPARG WNT7A 16835228 1606472 We found that and Fzd 9 expression *led* to increased [PPARgamma] activity . Positive_regulation PPARG ZFP57 20200519 2229609 Ectopic expression of in non-adipogenic NIH 3T3 fibroblasts robustly *activates* expression of [Pparg] in undifferentiated cells and permits cells to undergo adipocyte differentiation under permissive conditions . Positive_regulation PPARG ZFP57 20200519 2229627 *regulates* [Pparg] expression , in part , through amplification of the BMP signalling pathway , an effect dependent on the SMAD binding capacity of Zfp423 . Positive_regulation PPARGC1A FOXO1 12754525 1093587 Furthermore , function is *required* for the robust activation of gluconeogenic gene expression in hepatic cells and in mouse liver by [PGC-1alpha] . Positive_regulation PPARGC1A FOXO1 16527841 1561694 The expression of [PGC-1alpha] in muscle is *regulated* by myocyte enhancer factor 2 and , two transcription factors implicated in terminal muscle differentiation . Positive_regulation PPARGC1A FOXO1 18802029 1976224 Both SUR1-tg and Kir6.2 KO mice had decreased FOXO1 after transverse aortic constriction , in agreement with the reports that a decrease of can *repress* [PGC-1alpha] expression . Positive_regulation PPARGC1A MAP2K6 19233136 2050554 Furthermore , either forced expression of Ca ( 2+ ) - and calmodulin dependent protein kinase IV ( CaMKIV ) , calcineurin A , or the p38 mitogen activated protein kinase ( p38 MAPK ) kinase or the intracellular accumulation of cAMP *activated* the [PGC-1alpha-b] promoter in cultured myoblasts through recruitment of cAMP response element ( CRE ) -binding protein ( CREB ) to a putative CRE located downstream of the E-box . Positive_regulation PPBP ALOX5 2464942 104914 [MDGF] secretion by bleomycin stimulated alveolar macrophages was *inhibited* by cycloheximide , and the <5-lipoxygenase> inhibitors NDGA ( nordihydroguairetic acid ) and BW755c , indicating not only a requirement for protein synthesis but also for metabolites of the 5-lipoxygenase pathway of arachidonic acid metabolism for full expression of activity ( ABSTRACT TRUNCATED AT 250 WORDS ) Positive_regulation PPBP CSF2 21159337 2384810 M-CSF inhibited the expression of [pro-platelet basic protein (PPBP)] *induced* by . Positive_regulation PPBP GTF3C1 9171097 433269 The activity of strongly *enhances* specific binding of basal pol III factors TFIIIA , TFIIIC2 and the [PSE binding protein (PBP)] to their cognate promoter elements and it acts independently of the corresponding termination regions . Positive_regulation PPBP GTF3C2 9171097 433270 The activity of strongly *enhances* specific binding of basal pol III factors TFIIIA , TFIIIC2 and the [PSE binding protein (PBP)] to their cognate promoter elements and it acts independently of the corresponding termination regions . Positive_regulation PPBP GTF3C3 9171097 433271 The activity of strongly *enhances* specific binding of basal pol III factors TFIIIA , TFIIIC2 and the [PSE binding protein (PBP)] to their cognate promoter elements and it acts independently of the corresponding termination regions . Positive_regulation PPBP GTF3C4 9171097 433272 The activity of strongly *enhances* specific binding of basal pol III factors TFIIIA , TFIIIC2 and the [PSE binding protein (PBP)] to their cognate promoter elements and it acts independently of the corresponding termination regions . Positive_regulation PPBP GTF3C5 9171097 433273 The activity of strongly *enhances* specific binding of basal pol III factors TFIIIA , TFIIIC2 and the [PSE binding protein (PBP)] to their cognate promoter elements and it acts independently of the corresponding termination regions . Positive_regulation PPBP IL1A 23136963 2710747 Moreover , in P phase CTVT , while and TGF-ß *had* no obvious effect on [CXCL7] expression , IL-6 was found significantly to reduce CXCL7 expression in a dose dependent manner . Positive_regulation PPBP IL1A 24335961 2905206 CXCL7 promoted cell proliferation in vivo and in vitro , in which expression of [CXCL7] was *induced* by the central proinflammatory cytokine . Positive_regulation PPBP IL6 23136963 2710745 Now we intend to determine the expression pattern of CXCL7 and the *role* of in [CXCL7] induction during spontaneous progressive ( P ) and regressive ( R ) phases in canine transmissible venereal tumor ( CTVT ) . Positive_regulation PPBP LTB 3036988 74846 In contrast , the lipoxygenase pathway products and C4 ( LTC4 ) *stimulated* [MDGF] release in a dose dependent ( 10 ( -10 ) -10 ( -8 ) M ) manner , with LTC4 being more potent on a per unit dose basis . Positive_regulation PPL CAPN8 11803374 903015 Inhibitors of cathepsin or did not *inhibit* [PPL-cleavage] activity . Positive_regulation PPM1A TNF 18930133 2013562 [PPM1A] and PPM1B associate with the phosphorylated form of IKKbeta , and the interaction between PPM1A/PPM1B and IKKbeta is *induced* by in a transient fashion in the cells . Positive_regulation PPM1B TNF 18930133 2013565 PPM1A and [PPM1B] associate with the phosphorylated form of IKKbeta , and the interaction between PPM1A/PPM1B and IKKbeta is *induced* by in a transient fashion in the cells . Positive_regulation PPP1CC STK39 18083840 1837407 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation PPP1R12A EPHB2 15665049 1402424 Alpha1-adrenoceptor mediated phosphorylation of [MYPT-1] and CPI-17 in the uterine artery : *role* of . Positive_regulation PPP1R12A TNF 19427347 2106773 stimulated interleukin (IL)-6 release and *induced* the phosphorylation of myosin phosphatase targeting subunit ( [MYPT)-1] , a Rho-kinase substrate . Positive_regulation PPP1R12A TNF 23462755 2760705 as well as DR sera *promoted* [MYPT-1] phosphorylation in endothelial cells , which was significantly reduced by anti-TNF-a neutralizing antibody . Positive_regulation PPP1R14A EPHB2 15665049 1402423 Alpha1-adrenoceptor mediated phosphorylation of MYPT-1 and [CPI-17] in the uterine artery : *role* of . Positive_regulation PPP1R17 CAPN8 19105197 2042098 In vivo , NMDA immediately decreased [G-substrate] immunoreactivity , and the suppression of activation using ALLN or calpain III , an inhibitor of calpain , *blocked* this decrease . Positive_regulation PPP1R1B EPHB2 16954211 1633350 Under basal conditions , dopamine transporter knock-out mice show enhanced striatal [DARPP-32] phosphorylation , *activation* of , and inactivation of Akt as compared with wild-type littermates . Positive_regulation PPP1R1B EPHB2 22753408 2639433 These studies demonstrate that , in D1R expressing MSNs , l-DOPA induced activation of and mTORC1 *requires* [DARPP-32] and indicates the importance of the cAMP/DARPP-32 signaling cascade in dyskinesia . Positive_regulation PPP1R1B MAOA 23499958 2776912 The inhibition of both and MAO-B by clorgyline and pargyline , respectively , *enhanced* the effects of cocaine on [DARPP-32] phosphorylation . Positive_regulation PPP1R1B RARB 16026464 1435714 In light of the previous findings that DARPP-32 was inducible by retinoids in striatal culture , but not in cortical culture , we hypothesized that the striatum-selective and RXRgamma may *mediate* [DARPP-32] induction by retinoids . Positive_regulation PPP1R1B RARB 16026464 1435715 Ectopic expression of , but not RXRgamma1 , *up-regulated* [DARPP-32] in the cortical explant culture . Positive_regulation PPP1R1B RARB 16026464 1435716 Our study suggests that signaling may *regulate* [DARPP-32] gene expression by an isoform-specific mechanism in developing telencephalic neurons . Positive_regulation PPP1R3A EPHB2 19298253 2056074 [Rg1] could *induce* MEK protein expression and the phosphorylation level of MEK and significantly in a time- and dose dependent manner . Positive_regulation PPP1R3A MAP2K6 19298253 2056080 [Rg1] could *induce* MEK protein expression and the phosphorylation level of and ERK significantly in a time- and dose dependent manner . Positive_regulation PPP1R9B PTGER2 17408863 1736032 Treatment of newborn female rats with the EP receptor agonists iloprost , butaprost and sulprostone indicated that stimulation of both the and EP3 receptors significantly *increased* [spinophilin] , a protein whose levels positively correlate to the presence of dendritic spines and masculinization of the POA . Positive_regulation PPP2CA BPI 17012258 1629182 , but not control protein thaumatin , activated extracellular regulated kinase (ERK) and AKT , and *increased* DNA synthesis in RPE and [RPC] but not in REC . Positive_regulation PPP2CA NMNAT2 23579329 2794781 Whether can *activate* [PP2A] deserves to be explored . Positive_regulation PPP2CA NMNAT2 23579329 2794787 Moreover , we further demonstrated that overexpression of Nmnat2 could activate PP2A with attenuation of tau phosphorylation , whereas downregulation of by shRNA *inhibited* [PP2A] with tau hyperphosphorylation at multiple AD-associated sites . Positive_regulation PPP2CA TNF 17872368 1823583 did not affect total cell Cx43-PP2A catalytic subunit interaction , but it did *induce* [PP2A] catalytic subunit recruitment to the Triton X-100 insoluble subcellular fraction , in which Cx43-gap junction plaques are recovered . Positive_regulation PPP2CA TNF 18292600 1891537 Endogenous AIP1-PP2A complex can be detected in the resting state , and *induces* a complex formation of [AIP1-PP2A] with ASK1 . Positive_regulation PPP2CA TNF 18292600 1891550 Furthermore , *induced* association of [PP2A] with ASK1 was diminished in AIP1-knockdown ECs , suggesting a critical role of AIP1 in recruiting PP2A to ASK1 . Positive_regulation PPP2CA TNF 8665940 369026 In contrast to PP-1 , *caused* a 60 % increase in [PP-2A] activity and insulin failed to prevent this TNF-alpha effect . Positive_regulation PPP2R1A NMNAT2 23579329 2794782 Whether can *activate* [PP2A] deserves to be explored . Positive_regulation PPP2R1A NMNAT2 23579329 2794788 Moreover , we further demonstrated that overexpression of Nmnat2 could activate PP2A with attenuation of tau phosphorylation , whereas downregulation of by shRNA *inhibited* [PP2A] with tau hyperphosphorylation at multiple AD-associated sites . Positive_regulation PPP2R1A TNF 17872368 1823585 did not affect total cell Cx43-PP2A catalytic subunit interaction , but it did *induce* [PP2A] catalytic subunit recruitment to the Triton X-100 insoluble subcellular fraction , in which Cx43-gap junction plaques are recovered . Positive_regulation PPP2R1A TNF 18292600 1891540 Endogenous AIP1-PP2A complex can be detected in the resting state , and *induces* a complex formation of [AIP1-PP2A] with ASK1 . Positive_regulation PPP2R1A TNF 18292600 1891552 Furthermore , *induced* association of [PP2A] with ASK1 was diminished in AIP1-knockdown ECs , suggesting a critical role of AIP1 in recruiting PP2A to ASK1 . Positive_regulation PPP2R1A TNF 8665940 369027 In contrast to PP-1 , *caused* a 60 % increase in [PP-2A] activity and insulin failed to prevent this TNF-alpha effect . Positive_regulation PPP2R2B NMNAT2 23579329 2794783 Whether can *activate* [PP2A] deserves to be explored . Positive_regulation PPP2R2B NMNAT2 23579329 2794789 Moreover , we further demonstrated that overexpression of Nmnat2 could activate PP2A with attenuation of tau phosphorylation , whereas downregulation of by shRNA *inhibited* [PP2A] with tau hyperphosphorylation at multiple AD-associated sites . Positive_regulation PPP2R2B TNF 17872368 1823587 did not affect total cell Cx43-PP2A catalytic subunit interaction , but it did *induce* [PP2A] catalytic subunit recruitment to the Triton X-100 insoluble subcellular fraction , in which Cx43-gap junction plaques are recovered . Positive_regulation PPP2R2B TNF 18292600 1891543 Endogenous AIP1-PP2A complex can be detected in the resting state , and *induces* a complex formation of [AIP1-PP2A] with ASK1 . Positive_regulation PPP2R2B TNF 18292600 1891554 Furthermore , *induced* association of [PP2A] with ASK1 was diminished in AIP1-knockdown ECs , suggesting a critical role of AIP1 in recruiting PP2A to ASK1 . Positive_regulation PPP2R2B TNF 8665940 369028 In contrast to PP-1 , *caused* a 60 % increase in [PP-2A] activity and insulin failed to prevent this TNF-alpha effect . Positive_regulation PPP2R4 MMP28 10704614 672965 To demonstrate the association between the [protein-tyrosine phosphorylation (PTP) and] the *activation* of extracellular in the proliferation and migration of vascular smooth muscle cells ( VSMCs ) , the effect of platelet derived growth factor ( PDGF ) and vanadate ( an inhibitor of protein-tyrosine phosphatase and an activator of certain protein-tyrosine kinases ) on mitogenesis ( [ 3H ] thymidine incorporation after 24 hours ) , migration , PTP ( Western blot analysis using anti-phosphotyrosine antibodies ) , and production of MMP ( gelatin zymography ) was examined in cultured VSMCs . Positive_regulation PPP2R4 MMP7 10704614 672980 To demonstrate the association between the [protein-tyrosine phosphorylation (PTP) and] the *activation* of extracellular in the proliferation and migration of vascular smooth muscle cells ( VSMCs ) , the effect of platelet derived growth factor ( PDGF ) and vanadate ( an inhibitor of protein-tyrosine phosphatase and an activator of certain protein-tyrosine kinases ) on mitogenesis ( [ 3H ] thymidine incorporation after 24 hours ) , migration , PTP ( Western blot analysis using anti-phosphotyrosine antibodies ) , and production of MMP ( gelatin zymography ) was examined in cultured VSMCs . Positive_regulation PPP3CA CAPN8 14627704 1201020 Critical role of *mediated* cleavage of [calcineurin] in excitotoxic neurodegeneration . Positive_regulation PPP3CA CAPN8 17593948 1764726 Recent studies have demonstrated an interplay between calpain and calcineurin , in which can directly *regulate* [calcineurin] activity through proteolysis in glutamate stimulated neurons in culture and in vivo . Positive_regulation PPP3CA CAPN8 17826176 1817576 Furthermore , we provide evidence that Sema5B induces *mediated* cleavage of [calcineurin] . Positive_regulation PPP3CA CAPN8 23365236 2738911 [Calcineurin] can be *activated* by the Ca ( 2+ ) -activated protease , and immunostaining showed that both proteins are present at nerve terminals . Positive_regulation PPP3CA CAPN8 24987545 2947952 [Calcineurin] activity is *regulated* by , a cysteine protease present in the nucleus . Positive_regulation PPP3CA CAPN8 24987545 2948036 Thus , we examined whether *regulates* [calcineurin] in renal tubule nuclei . Positive_regulation PPP3CA EDN2 15124920 1242486 In addition to these protective pathways common among cell types , *activates* the calcium activated phosphatase [calcineurin] , which is necessary for the nuclear import of NFAT transcription factors . Positive_regulation PPP3CA FAS 17644576 1798828 In vitro , stimulation *augmented* [calcineurin] activity and induced apoptosis among infarct tissue derived myofibroblasts ; Positive_regulation PPP3CA PRODH 15914462 1440305 The *activation* of [calcineurin] by p53 and was detected by activation of the nuclear factor of activated T cells ( NFAT ) , an established indicator of activated calcineurin . Positive_regulation PPP3CA RCAN1 12554096 1051464 Transcription of the mammalian gene is *induced* by [calcineurin] , suggesting that it functions as an endogenous feedback regulator of calcineurin signal transduction . Positive_regulation PPP3CA RCAN1 16649988 1557390 While can *regulate* [calcineurin] and GSK-3beta , it has also been shown that calcineurin and GSK-3beta can regulate RCAN1s . Positive_regulation PPP3CA RCAN1 17700645 1903066 We hypothesize that the overexpression of in persons with DS and Ts65Dn mice would *inhibit* normal [calcineurin] activity and produce pathological increases in NMDAR mean open time and opening probability . Positive_regulation PPP3CA RCAN1 18045910 1832889 ( RCAN1/MCIP1/DSCR1 ) *regulates* the calmodulin dependent phosphatase [calcineurin] . Positive_regulation PPP3CA RCAN1 19509306 2142343 A promoter assay further demonstrated that inhibition of degradation in cells *reduced* [calcineurin-NFAT] activity . Positive_regulation PPP3CA RCAN1 20371871 2261759 Together , these findings suggest that [calcineurin/NFAT] *activation* of expression is in part dependent upon C/EBPbeta , whereas activation by C/EBPbeta is not dependent on calcineurin and may provide a calcineurin independent pathway for regulating RCAN1-4 expression . Positive_regulation PPP3CA RCAN1 21965663 2507437 Phosphorylation of at Thr ( 192 ) by Dyrk1A *enhances* the ability of RCAN1 to inhibit the phosphatase activity of [calcineurin (Caln)] , leading to reduced NFAT transcriptional activity and enhanced Tau phosphorylation . Positive_regulation PPP3CA S100B 15076760 1233060 The results indicate that ( 5-10 microM ) *increased* the activity of both purified and cytoskeletal [calcineurin] in a Ca-dependent manner . Positive_regulation PPP3CA TNF 9973478 596198 Calcium dependent *activation* of family gene expression by Ca2+/calmodulin kinase type IV/Gr and [calcineurin] . Positive_regulation PPP3CB CAPN8 14627704 1201034 Critical role of *mediated* cleavage of [calcineurin] in excitotoxic neurodegeneration . Positive_regulation PPP3CB CAPN8 23365236 2738925 [Calcineurin] can be *activated* by the Ca ( 2+ ) -activated protease , and immunostaining showed that both proteins are present at nerve terminals . Positive_regulation PPP3CB CAPN8 24987545 2947966 [Calcineurin] activity is *regulated* by , a cysteine protease present in the nucleus . Positive_regulation PPP3CB CAPN8 24987545 2948050 Thus , we examined whether *regulates* [calcineurin] in renal tubule nuclei . Positive_regulation PPP3CB EDN2 15124920 1242489 In addition to these protective pathways common among cell types , *activates* the calcium activated phosphatase [calcineurin] , which is necessary for the nuclear import of NFAT transcription factors . Positive_regulation PPP3CB FAS 17644576 1798829 In vitro , stimulation *augmented* [calcineurin] activity and induced apoptosis among infarct tissue derived myofibroblasts ; Positive_regulation PPP3CB RCAN1 12554096 1051465 Transcription of the mammalian gene is *induced* by [calcineurin] , suggesting that it functions as an endogenous feedback regulator of calcineurin signal transduction . Positive_regulation PPP3CB RCAN1 17700645 1903067 We hypothesize that the overexpression of in persons with DS and Ts65Dn mice would *inhibit* normal [calcineurin] activity and produce pathological increases in NMDAR mean open time and opening probability . Positive_regulation PPP3CB RCAN1 18045910 1832891 ( RCAN1/MCIP1/DSCR1 ) *regulates* the calmodulin dependent phosphatase [calcineurin] . Positive_regulation PPP3CB RCAN1 19509306 2142344 A promoter assay further demonstrated that inhibition of degradation in cells *reduced* [calcineurin-NFAT] activity . Positive_regulation PPP3CB RCAN1 20371871 2261760 Together , these findings suggest that [calcineurin/NFAT] *activation* of expression is in part dependent upon C/EBPbeta , whereas activation by C/EBPbeta is not dependent on calcineurin and may provide a calcineurin independent pathway for regulating RCAN1-4 expression . Positive_regulation PPP3CB TNF 9973478 596199 Calcium dependent *activation* of family gene expression by Ca2+/calmodulin kinase type IV/Gr and [calcineurin] . Positive_regulation PPP3CC CAPN8 14627704 1201048 Critical role of *mediated* cleavage of [calcineurin] in excitotoxic neurodegeneration . Positive_regulation PPP3CC CAPN8 23365236 2738939 [Calcineurin] can be *activated* by the Ca ( 2+ ) -activated protease , and immunostaining showed that both proteins are present at nerve terminals . Positive_regulation PPP3CC CAPN8 24987545 2947980 [Calcineurin] activity is *regulated* by , a cysteine protease present in the nucleus . Positive_regulation PPP3CC CAPN8 24987545 2948064 Thus , we examined whether *regulates* [calcineurin] in renal tubule nuclei . Positive_regulation PPP3CC EDN2 15124920 1242492 In addition to these protective pathways common among cell types , *activates* the calcium activated phosphatase [calcineurin] , which is necessary for the nuclear import of NFAT transcription factors . Positive_regulation PPP3CC FAS 17644576 1798830 In vitro , stimulation *augmented* [calcineurin] activity and induced apoptosis among infarct tissue derived myofibroblasts ; Positive_regulation PPP3CC RCAN1 12554096 1051466 Transcription of the mammalian gene is *induced* by [calcineurin] , suggesting that it functions as an endogenous feedback regulator of calcineurin signal transduction . Positive_regulation PPP3CC RCAN1 17700645 1903068 We hypothesize that the overexpression of in persons with DS and Ts65Dn mice would *inhibit* normal [calcineurin] activity and produce pathological increases in NMDAR mean open time and opening probability . Positive_regulation PPP3CC RCAN1 18045910 1832893 ( RCAN1/MCIP1/DSCR1 ) *regulates* the calmodulin dependent phosphatase [calcineurin] . Positive_regulation PPP3CC RCAN1 19509306 2142345 A promoter assay further demonstrated that inhibition of degradation in cells *reduced* [calcineurin-NFAT] activity . Positive_regulation PPP3CC RCAN1 20371871 2261761 Together , these findings suggest that [calcineurin/NFAT] *activation* of expression is in part dependent upon C/EBPbeta , whereas activation by C/EBPbeta is not dependent on calcineurin and may provide a calcineurin independent pathway for regulating RCAN1-4 expression . Positive_regulation PPP3CC TNF 9973478 596200 Calcium dependent *activation* of family gene expression by Ca2+/calmodulin kinase type IV/Gr and [calcineurin] . Positive_regulation PPP3R1 CAPN8 17593948 1764740 Recent studies have demonstrated an interplay between calpain and calcineurin , in which can directly *regulate* [calcineurin] activity through proteolysis in glutamate stimulated neurons in culture and in vivo . Positive_regulation PPP3R1 CAPN8 17826176 1817591 Furthermore , we provide evidence that Sema5B induces *mediated* cleavage of [calcineurin] . Positive_regulation PPP3R1 IGFBP1 16291950 1484570 LTP induction was blocked in the *presence* of the inhibitors okadaic acid and microcystin LR , the PP1 inhibitory peptide inhibitor-2 , the PP2A inhibitor fostriecin , and the [PP2B] inhibitor cyclosporin A. LTP induction was not impaired by the PKC inhibitor chelerythrine . Positive_regulation PPP3R1 PRODH 15914462 1440307 The *activation* of [calcineurin] by p53 and was detected by activation of the nuclear factor of activated T cells ( NFAT ) , an established indicator of activated calcineurin . Positive_regulation PPP3R1 RCAN1 16649988 1557391 While can *regulate* [calcineurin] and GSK-3beta , it has also been shown that calcineurin and GSK-3beta can regulate RCAN1s . Positive_regulation PPP3R1 RCAN1 21965663 2507438 Phosphorylation of at Thr ( 192 ) by Dyrk1A *enhances* the ability of RCAN1 to inhibit the phosphatase activity of [calcineurin (Caln)] , leading to reduced NFAT transcriptional activity and enhanced Tau phosphorylation . Positive_regulation PPP3R1 S100B 15076760 1233061 The results indicate that ( 5-10 microM ) *increased* the activity of both purified and cytoskeletal [calcineurin] in a Ca-dependent manner . Positive_regulation PPP5C IL1B 14622206 1168659 Herbimycin A and genistein also decreased *induced* expression of [PPT] mRNA encoding transcripts and the levels of SP-li synthesized in the cells and secreted into the culture medium in a concentration dependent manner . Positive_regulation PPP5C TFPI2 11945080 930055 Subcellular localization of [PP5/TFPI-2] in human placenta : a possible *role* of as an anti-coagulant on the surface of syncytiotrophoblasts . Positive_regulation PPP5C TNF 18068095 1846973 [OK-TX-ppt] also *induced* , IL-10 , IL-12 , and interferon (IFN)-gamma in PBMC . Positive_regulation PPP5C TNF 8592105 341981 dose-dependently *induces* SP , an induction that is secondary to an increase in the SP precursor , [preprotachykinin (PPT)] , mRNA . Positive_regulation PPRC1 PGC 23927032 2844986 In the brain , and PGC-1ß were unchanged , but [PGC-1 related co-activator] expression and mitochondrial DNA copy number *increased* . Positive_regulation PRAME TNFSF10 20838376 2375366 Finally , knocking down [PRAME] or EZH2 , and consequently induction of expression , *enhances* Imatinib sensibility . Positive_regulation PRDM2 TNF 20594067 2316021 [RIZ1] expression was induced in *response* to . Positive_regulation PRDM2 TNF 20594067 2316025 On the other hand , a p53 inhibitor enhanced the *induced* [RIZ1] expression . Positive_regulation PRDX1 IL1B 17890051 1843607 *Role* of and 5-HT2 receptors in midbrain [periaqueductal gray (PAG)] in potentiating defensive rage behavior in cat . Positive_regulation PRDX2 ARSA 3563969 68290 This is demonstrated by the fact that when PRP and RBC obtained from the same subjects before and two hours after the ingestion of ASA ( 0.5 g ) were mixed , it was found that *stimulate* [ASA-PRP] , probably through a platelet cyclooxygenase independent pathway ; Positive_regulation PRDX2 ARSA 3563969 68291 , however , *stimulate* [non-ASA-PRP] , but not ASA-PRP , which suggests that they may need an active platelet cyclooxygenase system for their action . Positive_regulation PRDX2 CCND1 16503970 1529137 We have demonstrated previously , that [TSA] *induces* the ubiquitin dependent degradation of in MCF-7 breast cancer cells . Positive_regulation PRDX2 CTGF 19404935 2075164 Most interestingly , [TSA] *induced* the expression of and ICAM-1 , while silencing of HDAC-7 had no effect on their expression . Positive_regulation PRDX2 TNF 25097261 2954244 Consistent with being part of an inflammatory cascade , we find that [PRDX2] then *induces* release . Positive_regulation PRDX2 VSNL1 18301774 1873489 [Trichostatin A (TSA)] , a histone deacetylase inhibitor , potently *induced* expression , indicating that histone deacetylation is an additional mechanism of VILIP-1 silencing . Positive_regulation PRDX4 CAPN8 21187494 2358813 It is the first time that a [Prx IV] *dependent* up-regulation is revealed . Positive_regulation PRDX5 ALOX5 15123685 1258672 In contrast , metabolites of 5-lipoxygenase were poor inhibitors of isolated thioredoxin reductase , and the overexpression of <5-lipoxygenase> did not *inhibit* [thioredoxin reductase] or cause a G cell cycle arrest . Positive_regulation PRDX5 FOXO1 22858408 2687423 *mediated* [PeroxiredoxinV] expression regulates redox homeostasis during Drosophila melanogaster gut infection . Positive_regulation PRDX6 EPHB2 21346153 2431589 These findings suggest that and p38 MAPK *regulate* subcellular localization of [Prdx6] by activation of 14-3-3e as a chaperone protein , resulting in its translocation to acidic organelles . Positive_regulation PRDX6 MAP2K6 17382207 1715515 Inhibitors of both PKC and largely *prevented* [Prdx6] induction by KGF and , to a lesser extent , TNF-alpha . Positive_regulation PRF1 TNF 11466378 839984 [pfp] ( -/- ) than from B6.gld mice , and residual levels of virus-specific killing of hepatocyte targets by FasL-defective B6.gld CTL were *blocked* by inhibition . Positive_regulation PRG2 CHI3L1 11467840 840763 At 7.6 nM , increased the number of cells of 42 % in GPC , 75 % in RC , and 86 % in RS after 72 h . YKL-40 also *stimulated* total [proteoglycan] synthesis by chondrocytes in a dose dependent manner as assessed by Na [ 35SO4 ] incorporation and cetylpyridinium chloride precipitation . Positive_regulation PRG2 CHI3L1 11467840 840766 At 9.4 nM , *increased* [proteoglycan] synthesis of 42 % in GPC and 58 % in RC after 24 h . Positive_regulation PRG2 CTGF 20819546 2318403 Compared to the control , *promoted* the synthesis of collagen type II and [proteoglycan] . Positive_regulation PRG2 CTGF 21933582 2487356 Both and TIMP1 transfected cell transplantation helps to maintain disc height , and *promotes* the biosynthesis of type II collagen and [proteoglycan] in intervertebral discs , reversing the degeneration of intervertebral discs . Positive_regulation PRG2 EDN2 20625315 2327849 Endothelin-1 stimulation of [proteoglycan] synthesis in vascular smooth muscle is *mediated* by receptor transactivation of the transforming growth factor-[beta ] type I receptor . Positive_regulation PRG2 EPHB2 15801908 1432391 Although IGF-I also activates the ERK/MAPK pathway , activity is not *required* for [proteoglycan] synthesis and may serve as a negative regulator . Positive_regulation PRG2 IL1B 10197168 561073 Matrix degradation by chondrocytes cultured in alginate : *induces* [proteoglycan] degradation and proMMP synthesis but does not result in collagen degradation . Positive_regulation PRG2 IL1B 11286988 799907 ( iii ) peroxynitrite accounts likely for stimulation of COX-2 activity and inhibition of [proteoglycan] synthesis *induced* by . Positive_regulation PRG2 IL1B 12115742 964353 *stimulated* [proteoglycan] degradation in the early days and inhibited proteoglycan synthesis through Day 14 . Positive_regulation PRG2 IL1B 12124863 965849 also *induced* cartilage [proteoglycan] degradation in OA synovial membrane-cartilage cocultures . Positive_regulation PRG2 IL1B 12405690 1009890 At 25 mg/ml glucosamine also prevented *induced* increases in nitric oxide production , prostaglandin E2 and [proteoglycan] release to media . Positive_regulation PRG2 IL1B 14722210 1197891 Dual effects of 17beta-oestradiol on *induced* [proteoglycan] degradation in chondrocytes . Positive_regulation PRG2 IL1B 14722210 1197894 To determine whether 17beta-oestradiol ( E2 ) modulates *induced* [proteoglycan] degradation in chondrocytes , and to analyse the part played by metalloproteinases ( MMPs ) in this process . Positive_regulation PRG2 IL1B 16544161 1561927 The current study demonstrates that the application of dynamic compression induced an inhibition of *NO and an upregulation of cell proliferation and [proteoglycan] synthesis in the *presence* and absence of . Positive_regulation PRG2 IL1B 16912414 1602067 The IL-1beta induced inhibition of cell proliferation was not influenced by 1400W or NS-398 whereas strain induced stimulation of [proteoglycan] synthesis in the *presence* of was enhanced by 1400W . Positive_regulation PRG2 IL1B 17949960 1894482 All tested compounds inhibited dose-dependently *induced* [proteoglycan] release and nitric oxide production by cartilage , indicating cartilage protective activity . Positive_regulation PRG2 IL1B 18545934 1958963 Dynamic compression stimulates cell proliferation and [proteoglycan] synthesis in the *presence* of and/or inhibitors of the MAPKs and NFkappaB and AP-1 signalling pathways . Positive_regulation PRG2 IL1B 19307458 2080189 The CAT fraction inhibited the *induced* [proteoglycan (PG)] release and nitric oxide ( NO ) production by cartilage explants in a dose dependent manner . Positive_regulation PRG2 IL1B 19542681 2099184 In a screening program aimed at discovering anti-osteoarthritis ( OA ) drugs , we identified an imidazo [ 5,1-c ] [ 1,4 ] thiazine derivative , ITZ-1 , that suppressed both *induced* [proteoglycan] and collagen release from bovine nasal cartilage in vitro and suppressed intra-articular infusion of IL-1beta induced cartilage proteoglycan degradation in rat knee joints . Positive_regulation PRG2 IL1B 19836480 2203154 Curcumin blocks *induced* [proteoglycan] degradation , AP-1/NF-kappaB signalling , chondrocyte apoptosis and activation of caspase-3 . Positive_regulation PRG2 IL1B 7932530 275359 These isothiazolones have been shown to exhibit potent , dose dependent inhibition of *induced* breakdown of [proteoglycan] in a cartilage organ culture assay . Positive_regulation PRG2 IL1B 9621897 510915 , added to the 8-week culture for 2 weeks , *caused* a decrease of 60 % in thickness , a decrease of 81 % in [proteoglycan] content , and a decrease of 31 % in collagen content ; Positive_regulation PRG2 MMP28 10220591 609331 The degradation of [proteoglycan] was *inhibited* by and inhibitor , indicating that MMPs are involved in the degradation of proteoglycans induced by high frequency CTF . Positive_regulation PRG2 MMP7 10220591 609346 The degradation of [proteoglycan] was *inhibited* by and inhibitor , indicating that MMPs are involved in the degradation of proteoglycans induced by high frequency CTF . Positive_regulation PRG2 MMP7 10642592 660964 Using macrophages isolated from MMP-null mice , we report that macrophage produced was *required* for [proteoglycan] degradation , loss of wet weight , and macrophage infiltration of cocultured discs . Positive_regulation PRG2 TF 2707185 111107 *stimulates* [proteoglycan] accumulation by fetal lung cells in culture . Positive_regulation PRG2 TNF 12202119 983016 To examine the effects of agonists of peroxisome proliferator activated receptor ( PPAR) gamma on [proteoglycan] degradation *induced* by interleukin (IL)-1beta or in cartilage in vitro . Positive_regulation PRG2 TNF 19026578 2059527 Indomethacin , dexamethasone , and an aggrecanase inhibitor were evaluated for their ability to modulate *induced* [proteoglycan] degradation in vivo . Positive_regulation PRG2 TNF 2349439 135100 Recombinant human *enhanced* neutrophil mediated degradation of [proteoglycan] , even when neutrophils were preincubated with TNF alpha and washed before incubating with cartilage . Positive_regulation PRG2 TNF 2801305 119952 IL-1 , 1 to 100 ng/ml , and , 10 to 1,000 ng/ml , *increased* [proteoglycan] degradation . Positive_regulation PRG2 TNF 7864640 296375 and retinoic acid also *stimulated* [proteoglycan] degradation in chondrocyte monolayers , and in both cases the response was inhibited by bafilomycin A1 . Positive_regulation PRG2 TNF 9647662 515090 It potently inhibited interleukin 1- and *stimulated* [proteoglycan] release from both nasal and articular cartilage . Positive_regulation PRG2 TNF 9770330 538830 In contrast , neutralization of IL-1 , but not , *resulted* in a significant decrease of chondrocyte [proteoglycan] synthesis inhibition . Positive_regulation PRG3 CHI3L1 11467840 840764 At 7.6 nM , increased the number of cells of 42 % in GPC , 75 % in RC , and 86 % in RS after 72 h . YKL-40 also *stimulated* total [proteoglycan] synthesis by chondrocytes in a dose dependent manner as assessed by Na [ 35SO4 ] incorporation and cetylpyridinium chloride precipitation . Positive_regulation PRG3 CHI3L1 11467840 840767 At 9.4 nM , *increased* [proteoglycan] synthesis of 42 % in GPC and 58 % in RC after 24 h . Positive_regulation PRG3 CTGF 20819546 2318404 Compared to the control , *promoted* the synthesis of collagen type II and [proteoglycan] . Positive_regulation PRG3 CTGF 21933582 2487357 Both and TIMP1 transfected cell transplantation helps to maintain disc height , and *promotes* the biosynthesis of type II collagen and [proteoglycan] in intervertebral discs , reversing the degeneration of intervertebral discs . Positive_regulation PRG3 EDN2 20625315 2327852 Endothelin-1 stimulation of [proteoglycan] synthesis in vascular smooth muscle is *mediated* by receptor transactivation of the transforming growth factor-[beta ] type I receptor . Positive_regulation PRG3 EPHB2 15801908 1432392 Although IGF-I also activates the ERK/MAPK pathway , activity is not *required* for [proteoglycan] synthesis and may serve as a negative regulator . Positive_regulation PRG3 IL1B 10197168 561074 Matrix degradation by chondrocytes cultured in alginate : *induces* [proteoglycan] degradation and proMMP synthesis but does not result in collagen degradation . Positive_regulation PRG3 IL1B 11286988 799908 ( iii ) peroxynitrite accounts likely for stimulation of COX-2 activity and inhibition of [proteoglycan] synthesis *induced* by . Positive_regulation PRG3 IL1B 12115742 964354 *stimulated* [proteoglycan] degradation in the early days and inhibited proteoglycan synthesis through Day 14 . Positive_regulation PRG3 IL1B 12124863 965850 also *induced* cartilage [proteoglycan] degradation in OA synovial membrane-cartilage cocultures . Positive_regulation PRG3 IL1B 12405690 1009891 At 25 mg/ml glucosamine also prevented *induced* increases in nitric oxide production , prostaglandin E2 and [proteoglycan] release to media . Positive_regulation PRG3 IL1B 14722210 1197892 Dual effects of 17beta-oestradiol on *induced* [proteoglycan] degradation in chondrocytes . Positive_regulation PRG3 IL1B 14722210 1197895 To determine whether 17beta-oestradiol ( E2 ) modulates *induced* [proteoglycan] degradation in chondrocytes , and to analyse the part played by metalloproteinases ( MMPs ) in this process . Positive_regulation PRG3 IL1B 16544161 1561928 The current study demonstrates that the application of dynamic compression induced an inhibition of *NO and an upregulation of cell proliferation and [proteoglycan] synthesis in the *presence* and absence of . Positive_regulation PRG3 IL1B 16912414 1602068 The IL-1beta induced inhibition of cell proliferation was not influenced by 1400W or NS-398 whereas strain induced stimulation of [proteoglycan] synthesis in the *presence* of was enhanced by 1400W . Positive_regulation PRG3 IL1B 17949960 1894483 All tested compounds inhibited dose-dependently *induced* [proteoglycan] release and nitric oxide production by cartilage , indicating cartilage protective activity . Positive_regulation PRG3 IL1B 18545934 1958964 Dynamic compression stimulates cell proliferation and [proteoglycan] synthesis in the *presence* of and/or inhibitors of the MAPKs and NFkappaB and AP-1 signalling pathways . Positive_regulation PRG3 IL1B 19307458 2080190 The CAT fraction inhibited the *induced* [proteoglycan (PG)] release and nitric oxide ( NO ) production by cartilage explants in a dose dependent manner . Positive_regulation PRG3 IL1B 19542681 2099185 In a screening program aimed at discovering anti-osteoarthritis ( OA ) drugs , we identified an imidazo [ 5,1-c ] [ 1,4 ] thiazine derivative , ITZ-1 , that suppressed both *induced* [proteoglycan] and collagen release from bovine nasal cartilage in vitro and suppressed intra-articular infusion of IL-1beta induced cartilage proteoglycan degradation in rat knee joints . Positive_regulation PRG3 IL1B 19836480 2203156 Curcumin blocks *induced* [proteoglycan] degradation , AP-1/NF-kappaB signalling , chondrocyte apoptosis and activation of caspase-3 . Positive_regulation PRG3 IL1B 7932530 275360 These isothiazolones have been shown to exhibit potent , dose dependent inhibition of *induced* breakdown of [proteoglycan] in a cartilage organ culture assay . Positive_regulation PRG3 IL1B 9621897 510916 , added to the 8-week culture for 2 weeks , *caused* a decrease of 60 % in thickness , a decrease of 81 % in [proteoglycan] content , and a decrease of 31 % in collagen content ; Positive_regulation PRG3 MMP28 10220591 609353 The degradation of [proteoglycan] was *inhibited* by and inhibitor , indicating that MMPs are involved in the degradation of proteoglycans induced by high frequency CTF . Positive_regulation PRG3 MMP7 10220591 609368 The degradation of [proteoglycan] was *inhibited* by and inhibitor , indicating that MMPs are involved in the degradation of proteoglycans induced by high frequency CTF . Positive_regulation PRG3 MMP7 10642592 660965 Using macrophages isolated from MMP-null mice , we report that macrophage produced was *required* for [proteoglycan] degradation , loss of wet weight , and macrophage infiltration of cocultured discs . Positive_regulation PRG3 TF 2707185 111108 *stimulates* [proteoglycan] accumulation by fetal lung cells in culture . Positive_regulation PRG3 TNF 12202119 983018 To examine the effects of agonists of peroxisome proliferator activated receptor ( PPAR) gamma on [proteoglycan] degradation *induced* by interleukin (IL)-1beta or in cartilage in vitro . Positive_regulation PRG3 TNF 19026578 2059528 Indomethacin , dexamethasone , and an aggrecanase inhibitor were evaluated for their ability to modulate *induced* [proteoglycan] degradation in vivo . Positive_regulation PRG3 TNF 2349439 135101 Recombinant human *enhanced* neutrophil mediated degradation of [proteoglycan] , even when neutrophils were preincubated with TNF alpha and washed before incubating with cartilage . Positive_regulation PRG3 TNF 2801305 119953 IL-1 , 1 to 100 ng/ml , and , 10 to 1,000 ng/ml , *increased* [proteoglycan] degradation . Positive_regulation PRG3 TNF 7864640 296376 and retinoic acid also *stimulated* [proteoglycan] degradation in chondrocyte monolayers , and in both cases the response was inhibited by bafilomycin A1 . Positive_regulation PRG3 TNF 9647662 515091 It potently inhibited interleukin 1- and *stimulated* [proteoglycan] release from both nasal and articular cartilage . Positive_regulation PRG3 TNF 9770330 538831 In contrast , neutralization of IL-1 , but not , *resulted* in a significant decrease of chondrocyte [proteoglycan] synthesis inhibition . Positive_regulation PRG4 CHI3L1 11467840 840765 At 7.6 nM , increased the number of cells of 42 % in GPC , 75 % in RC , and 86 % in RS after 72 h . YKL-40 also *stimulated* total [proteoglycan] synthesis by chondrocytes in a dose dependent manner as assessed by Na [ 35SO4 ] incorporation and cetylpyridinium chloride precipitation . Positive_regulation PRG4 CHI3L1 11467840 840768 At 9.4 nM , *increased* [proteoglycan] synthesis of 42 % in GPC and 58 % in RC after 24 h . Positive_regulation PRG4 CTGF 20819546 2318405 Compared to the control , *promoted* the synthesis of collagen type II and [proteoglycan] . Positive_regulation PRG4 CTGF 21933582 2487358 Both and TIMP1 transfected cell transplantation helps to maintain disc height , and *promotes* the biosynthesis of type II collagen and [proteoglycan] in intervertebral discs , reversing the degeneration of intervertebral discs . Positive_regulation PRG4 EDN2 20625315 2327855 Endothelin-1 stimulation of [proteoglycan] synthesis in vascular smooth muscle is *mediated* by receptor transactivation of the transforming growth factor-[beta ] type I receptor . Positive_regulation PRG4 EPHB2 15801908 1432393 Although IGF-I also activates the ERK/MAPK pathway , activity is not *required* for [proteoglycan] synthesis and may serve as a negative regulator . Positive_regulation PRG4 IL1B 10197168 561075 Matrix degradation by chondrocytes cultured in alginate : *induces* [proteoglycan] degradation and proMMP synthesis but does not result in collagen degradation . Positive_regulation PRG4 IL1B 11286988 799909 ( iii ) peroxynitrite accounts likely for stimulation of COX-2 activity and inhibition of [proteoglycan] synthesis *induced* by . Positive_regulation PRG4 IL1B 12115742 964355 *stimulated* [proteoglycan] degradation in the early days and inhibited proteoglycan synthesis through Day 14 . Positive_regulation PRG4 IL1B 12124863 965851 also *induced* cartilage [proteoglycan] degradation in OA synovial membrane-cartilage cocultures . Positive_regulation PRG4 IL1B 12405690 1009892 At 25 mg/ml glucosamine also prevented *induced* increases in nitric oxide production , prostaglandin E2 and [proteoglycan] release to media . Positive_regulation PRG4 IL1B 14722210 1197893 Dual effects of 17beta-oestradiol on *induced* [proteoglycan] degradation in chondrocytes . Positive_regulation PRG4 IL1B 14722210 1197896 To determine whether 17beta-oestradiol ( E2 ) modulates *induced* [proteoglycan] degradation in chondrocytes , and to analyse the part played by metalloproteinases ( MMPs ) in this process . Positive_regulation PRG4 IL1B 16544161 1561929 The current study demonstrates that the application of dynamic compression induced an inhibition of *NO and an upregulation of cell proliferation and [proteoglycan] synthesis in the *presence* and absence of . Positive_regulation PRG4 IL1B 16912414 1602069 The IL-1beta induced inhibition of cell proliferation was not influenced by 1400W or NS-398 whereas strain induced stimulation of [proteoglycan] synthesis in the *presence* of was enhanced by 1400W . Positive_regulation PRG4 IL1B 17949960 1894484 All tested compounds inhibited dose-dependently *induced* [proteoglycan] release and nitric oxide production by cartilage , indicating cartilage protective activity . Positive_regulation PRG4 IL1B 18545934 1958965 Dynamic compression stimulates cell proliferation and [proteoglycan] synthesis in the *presence* of and/or inhibitors of the MAPKs and NFkappaB and AP-1 signalling pathways . Positive_regulation PRG4 IL1B 19307458 2080191 The CAT fraction inhibited the *induced* [proteoglycan (PG)] release and nitric oxide ( NO ) production by cartilage explants in a dose dependent manner . Positive_regulation PRG4 IL1B 19542681 2099186 In a screening program aimed at discovering anti-osteoarthritis ( OA ) drugs , we identified an imidazo [ 5,1-c ] [ 1,4 ] thiazine derivative , ITZ-1 , that suppressed both *induced* [proteoglycan] and collagen release from bovine nasal cartilage in vitro and suppressed intra-articular infusion of IL-1beta induced cartilage proteoglycan degradation in rat knee joints . Positive_regulation PRG4 IL1B 19836480 2203158 Curcumin blocks *induced* [proteoglycan] degradation , AP-1/NF-kappaB signalling , chondrocyte apoptosis and activation of caspase-3 . Positive_regulation PRG4 IL1B 7932530 275361 These isothiazolones have been shown to exhibit potent , dose dependent inhibition of *induced* breakdown of [proteoglycan] in a cartilage organ culture assay . Positive_regulation PRG4 IL1B 9621897 510917 , added to the 8-week culture for 2 weeks , *caused* a decrease of 60 % in thickness , a decrease of 81 % in [proteoglycan] content , and a decrease of 31 % in collagen content ; Positive_regulation PRG4 MMP28 10220591 609375 The degradation of [proteoglycan] was *inhibited* by and inhibitor , indicating that MMPs are involved in the degradation of proteoglycans induced by high frequency CTF . Positive_regulation PRG4 MMP7 10220591 609390 The degradation of [proteoglycan] was *inhibited* by and inhibitor , indicating that MMPs are involved in the degradation of proteoglycans induced by high frequency CTF . Positive_regulation PRG4 MMP7 10642592 660966 Using macrophages isolated from MMP-null mice , we report that macrophage produced was *required* for [proteoglycan] degradation , loss of wet weight , and macrophage infiltration of cocultured discs . Positive_regulation PRG4 TF 2707185 111109 *stimulates* [proteoglycan] accumulation by fetal lung cells in culture . Positive_regulation PRG4 TNF 12202119 983020 To examine the effects of agonists of peroxisome proliferator activated receptor ( PPAR) gamma on [proteoglycan] degradation *induced* by interleukin (IL)-1beta or in cartilage in vitro . Positive_regulation PRG4 TNF 19026578 2059529 Indomethacin , dexamethasone , and an aggrecanase inhibitor were evaluated for their ability to modulate *induced* [proteoglycan] degradation in vivo . Positive_regulation PRG4 TNF 2349439 135102 Recombinant human *enhanced* neutrophil mediated degradation of [proteoglycan] , even when neutrophils were preincubated with TNF alpha and washed before incubating with cartilage . Positive_regulation PRG4 TNF 2801305 119954 IL-1 , 1 to 100 ng/ml , and , 10 to 1,000 ng/ml , *increased* [proteoglycan] degradation . Positive_regulation PRG4 TNF 7864640 296377 and retinoic acid also *stimulated* [proteoglycan] degradation in chondrocyte monolayers , and in both cases the response was inhibited by bafilomycin A1 . Positive_regulation PRG4 TNF 9647662 515092 It potently inhibited interleukin 1- and *stimulated* [proteoglycan] release from both nasal and articular cartilage . Positive_regulation PRG4 TNF 9770330 538832 In contrast , neutralization of IL-1 , but not , *resulted* in a significant decrease of chondrocyte [proteoglycan] synthesis inhibition . Positive_regulation PRKAA1 AXIN2 24093678 2852013 Importantly , adenovirus based knockdown of AXIN in the mouse liver impaired AMPK activation and caused exacerbated fatty liver after starvation , underscoring an essential *role* of in [AMPK] activation . Positive_regulation PRKAA1 C1QTNF1 22086915 2534477 In isolated soleus muscle , recombinant *activated* [AMPK] signaling to increase fatty acid oxidation ex vivo , an effect abrogated by an AMPK inhibitor . Positive_regulation PRKAA1 CCND1 24236567 2903149 We suggest that these tumours may arise through a mechanism involving ATP depletion , *activation* of [AMPK] , and induction of , and that this may be a unique pathway of tumour development that has the potential for therapeutic intervention in these rare tumours . Positive_regulation PRKAA1 EPHB2 19520853 2116099 *Activation* of by [AMPK] upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation PRKAA1 FAS 19477172 2097640 In the present study , we demonstrate that signaling in DU145 human prostate cancer cells *leads* to rapid activation of [AMP activated protein kinase (AMPK)] , which plays a major role in adaptive responses to ATP depleting conditions ; Positive_regulation PRKAA1 FAS 23349077 2754070 These results indicate that CDCQ prevented lipid accumulation by blocking the expression of SREBP-1c and through LKB1/SIRT1 and [AMPK] *activation* in HepG2 cells , suggesting that CDCQ plays a potential role in the prevention of lipogenesis by AMPK activation . Positive_regulation PRKAA1 FOXO1 19079687 2003231 Sepsis and [AMPK] *Activation* by AICAR Differentially Regulate , -3 and -4 mRNA in Striated Muscle . Positive_regulation PRKAA1 HRH1 24636512 2925640 These data suggest a time dependent change of signaling , where olanzapine *activates* [AMPK] by blocking the H1Rs and causing hyperphagia in the acute phase . Positive_regulation PRKAA1 IFI27 18701472 1950388 Cytoplasmic localization of p27 in Tsc2-null cells was reversible pharmacologically using inhibitors of the LKB1/AMPK pathway , and localization of to the cytoplasm could be *induced* directly by activating AMPK physiologically ( glucose deprivation ) or genetically ( constitutively active [AMPK] ) in Tsc2-proficient cells . Positive_regulation PRKAA1 MAP2K6 17728396 1817148 Taken together , our studies identify novel links between the physiological state of the cell , the *activation* of -- > ERK1/2 signaling , and the nucleocytoplasmic distribution of [AMPK] . Positive_regulation PRKAA1 MAP2K6 19520853 2116105 *Activation* of by [AMPK] upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation PRKAA1 MMP28 24255018 2904321 Adiponectin *mediated* [APPL1-AMPK] signaling induces cell migration , activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation PRKAA1 MMP7 24255018 2904336 Adiponectin *mediated* [APPL1-AMPK] signaling induces cell migration , activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation PRKAA1 PGC 21187426 2378905 Overexpression of in TKO MEFs elevated ATP levels and *inhibited* the activation of [AMPK] . Positive_regulation PRKAA1 PGC 21803289 2462289 Deletion of mIndy in mice ( mINDY ( -/- ) mice ) reduces hepatocellular ATP/ADP ratio , activates hepatic [AMPK] , *induces* , inhibits ACC-2 , and reduces SREBP-1c levels . Positive_regulation PRKAA1 PGC 21862727 2510295 [AMPK] phosphorylation increased to a greater extent in the R-leg , and AICAR stimulation of cultured human myotubes *induced* the expression of PGC-1a-a and . Positive_regulation PRKAA1 PGC 23090186 2717184 Resveratrol also lowered the NEFA and triacylglycerol content of the kidney , and this action was related to increases in the phosphorylation of [AMPK] and the *activation* of signalling and of the key downstream effectors , the PPARa-oestrogen related receptor ( ERR ) -1a-sterol regulatory element binding protein 1 ( SREBP1 ) . Positive_regulation PRKAA1 PGC 23090186 2717208 Resveratrol prevented high-glucose induced oxidative stress and apoptosis in cultured mesangial cells through the phosphorylation of [AMPK] and *activation* of signalling and the downstream effectors , PPARa-ERR-1a-SREBP1 . Positive_regulation PRKAA1 PGC 23090186 2717232 The results suggest that resveratrol prevents diabetic nephropathy in db/db mice by the phosphorylation of [AMPK] and *activation* of signalling , which appear to prevent lipotoxicity related apoptosis and oxidative stress in the kidney . Positive_regulation PRKAA1 PGC 23523698 2794262 Erythropoietin also increases [AMPK] , which *induces* and stimulates slow oxidative fiber formation . Positive_regulation PRKAA1 PLAT 23562854 2778016 Glucose deprivation induced activation of PI3K-Akt-GSK3ß , p38 and [AMPK] , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation PRKAA1 PLAT 23881246 2861370 Mass spectrometry and immunohistochemical studies show that the release of this in the synaptic space *induces* [AMPK] activation in the postsynaptic terminal , and an AMPK mediated increase in neuronal uptake of glucose and neuronal adenosine 5 ' ( tetrahydrogen triphosphate ; Positive_regulation PRKAA1 PLAT 24200922 2891720 This *induces* [AMPK] activation , membrane recruitment of GLUT1 , and GLUT1 mediated glucose uptake in astrocytes and endothelial cells . Positive_regulation PRKAA1 STK39 20029389 2192202 LKB1 is a that directly *activates* the energy sensor [AMP activated protein kinase (AMPK)] in response to bioenergetic stress , and mainly acts as a tumor suppressor that controls cell polarity and proliferation . Positive_regulation PRKAA1 TNF 17446186 1749520 also potently *stimulated* the phosphorylation of ERK1/2 and [AMPK] . Positive_regulation PRKAA1 TNF 17446186 1749528 Treatment with SB203580 decreased p38 MAPK phosphorylation back to the baseline and restored insulin sensitivity of IRS-1 tyrosine and Akt phosphorylation and eNOS activity in TNF-alpha treated bAECs without affecting *induced* ERK1/2 and [AMPK] phosphorylation . Positive_regulation PRKAA1 TNF 17446186 1749535 We conclude that in cultured bAECs , induces insulin resistance in the phosphatidylinositol 3-kinase/Akt/eNOS pathway via a p38 MAPK dependent mechanism and *enhances* ERK1/2 and [AMPK] phosphorylation independent of the p38 MAPK pathway . Positive_regulation PRKAA1 TNF 21427236 2412149 *induced* [AMPK] activation has been shown to be necessary for nuclear factor ?appa B ( NF-?B ) -induced inducible nitric oxide synthase expression and for blocking TNF-a induced apoptosis . Positive_regulation PRKAA1 TNFSF10 19197243 2049710 Interestingly , the induced [AMPK] *activation* is refractory to the depletion of the two known AMPK activating kinases , LKB1 and Ca ( 2+ ) /calmodulin dependent kinase kinase-beta , but depends on transforming growth factor-beta activating kinase 1 ( TAK1 ) and TAK1 binding subunit 2 . Positive_regulation PRKAA2 AXIN2 24093678 2852015 Importantly , adenovirus based knockdown of AXIN in the mouse liver impaired AMPK activation and caused exacerbated fatty liver after starvation , underscoring an essential *role* of in [AMPK] activation . Positive_regulation PRKAA2 C1QTNF1 22086915 2534478 In isolated soleus muscle , recombinant *activated* [AMPK] signaling to increase fatty acid oxidation ex vivo , an effect abrogated by an AMPK inhibitor . Positive_regulation PRKAA2 CCND1 24236567 2903150 We suggest that these tumours may arise through a mechanism involving ATP depletion , *activation* of [AMPK] , and induction of , and that this may be a unique pathway of tumour development that has the potential for therapeutic intervention in these rare tumours . Positive_regulation PRKAA2 EPHB2 19520853 2116107 *Activation* of by [AMPK] upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation PRKAA2 FAS 19477172 2097641 In the present study , we demonstrate that signaling in DU145 human prostate cancer cells *leads* to rapid activation of [AMP activated protein kinase (AMPK)] , which plays a major role in adaptive responses to ATP depleting conditions ; Positive_regulation PRKAA2 FAS 23349077 2754074 These results indicate that CDCQ prevented lipid accumulation by blocking the expression of SREBP-1c and through LKB1/SIRT1 and [AMPK] *activation* in HepG2 cells , suggesting that CDCQ plays a potential role in the prevention of lipogenesis by AMPK activation . Positive_regulation PRKAA2 FOXO1 19079687 2003232 Sepsis and [AMPK] *Activation* by AICAR Differentially Regulate , -3 and -4 mRNA in Striated Muscle . Positive_regulation PRKAA2 HRH1 24636512 2925641 These data suggest a time dependent change of signaling , where olanzapine *activates* [AMPK] by blocking the H1Rs and causing hyperphagia in the acute phase . Positive_regulation PRKAA2 IFI27 18701472 1950390 Cytoplasmic localization of p27 in Tsc2-null cells was reversible pharmacologically using inhibitors of the LKB1/AMPK pathway , and localization of to the cytoplasm could be *induced* directly by activating AMPK physiologically ( glucose deprivation ) or genetically ( constitutively active [AMPK] ) in Tsc2-proficient cells . Positive_regulation PRKAA2 MAP2K6 17728396 1817155 Taken together , our studies identify novel links between the physiological state of the cell , the *activation* of -- > ERK1/2 signaling , and the nucleocytoplasmic distribution of [AMPK] . Positive_regulation PRKAA2 MAP2K6 19520853 2116113 *Activation* of by [AMPK] upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation PRKAA2 MMP28 24255018 2904344 Adiponectin *mediated* [APPL1-AMPK] signaling induces cell migration , activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation PRKAA2 MMP7 24255018 2904359 Adiponectin *mediated* [APPL1-AMPK] signaling induces cell migration , activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation PRKAA2 PGC 21187426 2378906 Overexpression of in TKO MEFs elevated ATP levels and *inhibited* the activation of [AMPK] . Positive_regulation PRKAA2 PGC 21803289 2462290 Deletion of mIndy in mice ( mINDY ( -/- ) mice ) reduces hepatocellular ATP/ADP ratio , activates hepatic [AMPK] , *induces* , inhibits ACC-2 , and reduces SREBP-1c levels . Positive_regulation PRKAA2 PGC 21862727 2510296 [AMPK] phosphorylation increased to a greater extent in the R-leg , and AICAR stimulation of cultured human myotubes *induced* the expression of and PGC-1a-b . Positive_regulation PRKAA2 PGC 23090186 2717186 Resveratrol also lowered the NEFA and triacylglycerol content of the kidney , and this action was related to increases in the phosphorylation of [AMPK] and the *activation* of signalling and of the key downstream effectors , the PPARa-oestrogen related receptor ( ERR ) -1a-sterol regulatory element binding protein 1 ( SREBP1 ) . Positive_regulation PRKAA2 PGC 23090186 2717210 Resveratrol prevented high-glucose induced oxidative stress and apoptosis in cultured mesangial cells through the phosphorylation of [AMPK] and *activation* of signalling and the downstream effectors , PPARa-ERR-1a-SREBP1 . Positive_regulation PRKAA2 PGC 23090186 2717234 The results suggest that resveratrol prevents diabetic nephropathy in db/db mice by the phosphorylation of [AMPK] and *activation* of signalling , which appear to prevent lipotoxicity related apoptosis and oxidative stress in the kidney . Positive_regulation PRKAA2 PGC 23523698 2794264 Erythropoietin also increases [AMPK] , which *induces* and stimulates slow oxidative fiber formation . Positive_regulation PRKAA2 PLAT 23562854 2778017 Glucose deprivation induced activation of PI3K-Akt-GSK3ß , p38 and [AMPK] , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation PRKAA2 PLAT 23881246 2861371 Mass spectrometry and immunohistochemical studies show that the release of this in the synaptic space *induces* [AMPK] activation in the postsynaptic terminal , and an AMPK mediated increase in neuronal uptake of glucose and neuronal adenosine 5 ' ( tetrahydrogen triphosphate ; Positive_regulation PRKAA2 PLAT 24200922 2891721 This *induces* [AMPK] activation , membrane recruitment of GLUT1 , and GLUT1 mediated glucose uptake in astrocytes and endothelial cells . Positive_regulation PRKAA2 STK39 20029389 2192217 LKB1 is a that directly *activates* the energy sensor [AMP activated protein kinase (AMPK)] in response to bioenergetic stress , and mainly acts as a tumor suppressor that controls cell polarity and proliferation . Positive_regulation PRKAA2 TNF 17446186 1749521 also potently *stimulated* the phosphorylation of ERK1/2 and [AMPK] . Positive_regulation PRKAA2 TNF 17446186 1749529 Treatment with SB203580 decreased p38 MAPK phosphorylation back to the baseline and restored insulin sensitivity of IRS-1 tyrosine and Akt phosphorylation and eNOS activity in TNF-alpha treated bAECs without affecting *induced* ERK1/2 and [AMPK] phosphorylation . Positive_regulation PRKAA2 TNF 17446186 1749536 We conclude that in cultured bAECs , induces insulin resistance in the phosphatidylinositol 3-kinase/Akt/eNOS pathway via a p38 MAPK dependent mechanism and *enhances* ERK1/2 and [AMPK] phosphorylation independent of the p38 MAPK pathway . Positive_regulation PRKAA2 TNF 21427236 2412150 induced [AMPK] *activation* has been shown to be necessary for nuclear factor ?appa B ( NF-?B ) -induced inducible nitric oxide synthase expression and for blocking TNF-a induced apoptosis . Positive_regulation PRKAA2 TNFSF10 19197243 2049711 Interestingly , the *induced* [AMPK] activation is refractory to the depletion of the two known AMPK activating kinases , LKB1 and Ca ( 2+ ) /calmodulin dependent kinase kinase-beta , but depends on transforming growth factor-beta activating kinase 1 ( TAK1 ) and TAK1 binding subunit 2 . Positive_regulation PRKAB1 AXIN2 24093678 2852017 Importantly , adenovirus based knockdown of AXIN in the mouse liver impaired AMPK activation and caused exacerbated fatty liver after starvation , underscoring an essential *role* of in [AMPK] activation . Positive_regulation PRKAB1 C1QTNF1 22086915 2534479 In isolated soleus muscle , recombinant *activated* [AMPK] signaling to increase fatty acid oxidation ex vivo , an effect abrogated by an AMPK inhibitor . Positive_regulation PRKAB1 CCND1 24236567 2903151 We suggest that these tumours may arise through a mechanism involving ATP depletion , *activation* of [AMPK] , and induction of , and that this may be a unique pathway of tumour development that has the potential for therapeutic intervention in these rare tumours . Positive_regulation PRKAB1 EPHB2 19520853 2116115 *Activation* of by [AMPK] upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation PRKAB1 FAS 19477172 2097642 In the present study , we demonstrate that signaling in DU145 human prostate cancer cells *leads* to rapid activation of [AMP activated protein kinase (AMPK)] , which plays a major role in adaptive responses to ATP depleting conditions ; Positive_regulation PRKAB1 FAS 23349077 2754078 These results indicate that CDCQ prevented lipid accumulation by blocking the expression of SREBP-1c and through LKB1/SIRT1 and [AMPK] *activation* in HepG2 cells , suggesting that CDCQ plays a potential role in the prevention of lipogenesis by AMPK activation . Positive_regulation PRKAB1 FOXO1 19079687 2003233 Sepsis and [AMPK] *Activation* by AICAR Differentially Regulate , -3 and -4 mRNA in Striated Muscle . Positive_regulation PRKAB1 HRH1 24636512 2925642 These data suggest a time dependent change of signaling , where olanzapine *activates* [AMPK] by blocking the H1Rs and causing hyperphagia in the acute phase . Positive_regulation PRKAB1 IFI27 18701472 1950392 Cytoplasmic localization of p27 in Tsc2-null cells was reversible pharmacologically using inhibitors of the LKB1/AMPK pathway , and localization of to the cytoplasm could be *induced* directly by activating AMPK physiologically ( glucose deprivation ) or genetically ( constitutively active [AMPK] ) in Tsc2-proficient cells . Positive_regulation PRKAB1 MAP2K6 17728396 1817162 Taken together , our studies identify novel links between the physiological state of the cell , the *activation* of -- > ERK1/2 signaling , and the nucleocytoplasmic distribution of [AMPK] . Positive_regulation PRKAB1 MAP2K6 19520853 2116121 *Activation* of by [AMPK] upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation PRKAB1 MMP28 24255018 2904367 Adiponectin *mediated* [APPL1-AMPK] signaling induces cell migration , activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation PRKAB1 MMP7 24255018 2904382 Adiponectin *mediated* [APPL1-AMPK] signaling induces cell migration , activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation PRKAB1 PGC 21187426 2378907 Overexpression of in TKO MEFs elevated ATP levels and *inhibited* the activation of [AMPK] . Positive_regulation PRKAB1 PGC 21803289 2462291 Deletion of mIndy in mice ( mINDY ( -/- ) mice ) reduces hepatocellular ATP/ADP ratio , activates hepatic [AMPK] , *induces* , inhibits ACC-2 , and reduces SREBP-1c levels . Positive_regulation PRKAB1 PGC 21862727 2510297 [AMPK] phosphorylation increased to a greater extent in the R-leg , and AICAR stimulation of cultured human myotubes *induced* the expression of PGC-1a-a and . Positive_regulation PRKAB1 PGC 23090186 2717188 Resveratrol also lowered the NEFA and triacylglycerol content of the kidney , and this action was related to increases in the phosphorylation of [AMPK] and the *activation* of signalling and of the key downstream effectors , the PPARa-oestrogen related receptor ( ERR ) -1a-sterol regulatory element binding protein 1 ( SREBP1 ) . Positive_regulation PRKAB1 PGC 23090186 2717212 Resveratrol prevented high-glucose induced oxidative stress and apoptosis in cultured mesangial cells through the phosphorylation of [AMPK] and *activation* of signalling and the downstream effectors , PPARa-ERR-1a-SREBP1 . Positive_regulation PRKAB1 PGC 23090186 2717236 The results suggest that resveratrol prevents diabetic nephropathy in db/db mice by the phosphorylation of [AMPK] and *activation* of signalling , which appear to prevent lipotoxicity related apoptosis and oxidative stress in the kidney . Positive_regulation PRKAB1 PGC 23523698 2794266 Erythropoietin also increases [AMPK] , which *induces* and stimulates slow oxidative fiber formation . Positive_regulation PRKAB1 PLAT 23562854 2778018 Glucose deprivation induced activation of PI3K-Akt-GSK3ß , p38 and [AMPK] , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation PRKAB1 PLAT 23881246 2861372 Mass spectrometry and immunohistochemical studies show that the release of this in the synaptic space *induces* [AMPK] activation in the postsynaptic terminal , and an AMPK mediated increase in neuronal uptake of glucose and neuronal adenosine 5 ' ( tetrahydrogen triphosphate ; Positive_regulation PRKAB1 PLAT 24200922 2891722 This *induces* [AMPK] activation , membrane recruitment of GLUT1 , and GLUT1 mediated glucose uptake in astrocytes and endothelial cells . Positive_regulation PRKAB1 STK39 20029389 2192232 LKB1 is a that directly *activates* the energy sensor [AMP activated protein kinase (AMPK)] in response to bioenergetic stress , and mainly acts as a tumor suppressor that controls cell polarity and proliferation . Positive_regulation PRKAB1 TNF 17446186 1749522 also potently *stimulated* the phosphorylation of ERK1/2 and [AMPK] . Positive_regulation PRKAB1 TNF 17446186 1749530 Treatment with SB203580 decreased p38 MAPK phosphorylation back to the baseline and restored insulin sensitivity of IRS-1 tyrosine and Akt phosphorylation and eNOS activity in TNF-alpha treated bAECs without affecting *induced* ERK1/2 and [AMPK] phosphorylation . Positive_regulation PRKAB1 TNF 17446186 1749537 We conclude that in cultured bAECs , induces insulin resistance in the phosphatidylinositol 3-kinase/Akt/eNOS pathway via a p38 MAPK dependent mechanism and *enhances* ERK1/2 and [AMPK] phosphorylation independent of the p38 MAPK pathway . Positive_regulation PRKAB1 TNF 21427236 2412151 *induced* [AMPK] activation has been shown to be necessary for nuclear factor ?appa B ( NF-?B ) -induced inducible nitric oxide synthase expression and for blocking TNF-a induced apoptosis . Positive_regulation PRKAB1 TNFSF10 19197243 2049712 Interestingly , the *induced* [AMPK] activation is refractory to the depletion of the two known AMPK activating kinases , LKB1 and Ca ( 2+ ) /calmodulin dependent kinase kinase-beta , but depends on transforming growth factor-beta activating kinase 1 ( TAK1 ) and TAK1 binding subunit 2 . Positive_regulation PRKAB2 AXIN2 24093678 2852019 Importantly , adenovirus based knockdown of AXIN in the mouse liver impaired AMPK activation and caused exacerbated fatty liver after starvation , underscoring an essential *role* of in [AMPK] activation . Positive_regulation PRKAB2 C1QTNF1 22086915 2534480 In isolated soleus muscle , recombinant *activated* [AMPK] signaling to increase fatty acid oxidation ex vivo , an effect abrogated by an AMPK inhibitor . Positive_regulation PRKAB2 CCND1 24236567 2903152 We suggest that these tumours may arise through a mechanism involving ATP depletion , *activation* of [AMPK] , and induction of , and that this may be a unique pathway of tumour development that has the potential for therapeutic intervention in these rare tumours . Positive_regulation PRKAB2 EPHB2 19520853 2116123 *Activation* of by [AMPK] upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation PRKAB2 FAS 19477172 2097643 In the present study , we demonstrate that signaling in DU145 human prostate cancer cells *leads* to rapid activation of [AMP activated protein kinase (AMPK)] , which plays a major role in adaptive responses to ATP depleting conditions ; Positive_regulation PRKAB2 FAS 23349077 2754082 These results indicate that CDCQ prevented lipid accumulation by blocking the expression of SREBP-1c and through LKB1/SIRT1 and [AMPK] *activation* in HepG2 cells , suggesting that CDCQ plays a potential role in the prevention of lipogenesis by AMPK activation . Positive_regulation PRKAB2 FOXO1 19079687 2003234 Sepsis and [AMPK] *Activation* by AICAR Differentially Regulate , -3 and -4 mRNA in Striated Muscle . Positive_regulation PRKAB2 HRH1 24636512 2925643 These data suggest a time dependent change of signaling , where olanzapine *activates* [AMPK] by blocking the H1Rs and causing hyperphagia in the acute phase . Positive_regulation PRKAB2 IFI27 18701472 1950394 Cytoplasmic localization of p27 in Tsc2-null cells was reversible pharmacologically using inhibitors of the LKB1/AMPK pathway , and localization of to the cytoplasm could be *induced* directly by activating AMPK physiologically ( glucose deprivation ) or genetically ( constitutively active [AMPK] ) in Tsc2-proficient cells . Positive_regulation PRKAB2 MAP2K6 17728396 1817169 Taken together , our studies identify novel links between the physiological state of the cell , the *activation* of -- > ERK1/2 signaling , and the nucleocytoplasmic distribution of [AMPK] . Positive_regulation PRKAB2 MAP2K6 19520853 2116129 *Activation* of by [AMPK] upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation PRKAB2 MMP28 24255018 2904390 Adiponectin *mediated* [APPL1-AMPK] signaling induces cell migration , activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation PRKAB2 MMP7 24255018 2904405 Adiponectin *mediated* [APPL1-AMPK] signaling induces cell migration , activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation PRKAB2 PGC 21187426 2378908 Overexpression of in TKO MEFs elevated ATP levels and *inhibited* the activation of [AMPK] . Positive_regulation PRKAB2 PGC 21803289 2462292 Deletion of mIndy in mice ( mINDY ( -/- ) mice ) reduces hepatocellular ATP/ADP ratio , activates hepatic [AMPK] , *induces* , inhibits ACC-2 , and reduces SREBP-1c levels . Positive_regulation PRKAB2 PGC 21862727 2510298 [AMPK] phosphorylation increased to a greater extent in the R-leg , and AICAR stimulation of cultured human myotubes *induced* the expression of and PGC-1a-b . Positive_regulation PRKAB2 PGC 23090186 2717190 Resveratrol also lowered the NEFA and triacylglycerol content of the kidney , and this action was related to increases in the phosphorylation of [AMPK] and the *activation* of signalling and of the key downstream effectors , the PPARa-oestrogen related receptor ( ERR ) -1a-sterol regulatory element binding protein 1 ( SREBP1 ) . Positive_regulation PRKAB2 PGC 23090186 2717214 Resveratrol prevented high-glucose induced oxidative stress and apoptosis in cultured mesangial cells through the phosphorylation of [AMPK] and *activation* of signalling and the downstream effectors , PPARa-ERR-1a-SREBP1 . Positive_regulation PRKAB2 PGC 23090186 2717238 The results suggest that resveratrol prevents diabetic nephropathy in db/db mice by the phosphorylation of [AMPK] and *activation* of signalling , which appear to prevent lipotoxicity related apoptosis and oxidative stress in the kidney . Positive_regulation PRKAB2 PGC 23523698 2794268 Erythropoietin also increases [AMPK] , which *induces* and stimulates slow oxidative fiber formation . Positive_regulation PRKAB2 PLAT 23562854 2778019 Glucose deprivation induced activation of PI3K-Akt-GSK3ß , p38 and [AMPK] , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation PRKAB2 PLAT 23881246 2861373 Mass spectrometry and immunohistochemical studies show that the release of this in the synaptic space *induces* [AMPK] activation in the postsynaptic terminal , and an AMPK mediated increase in neuronal uptake of glucose and neuronal adenosine 5 ' ( tetrahydrogen triphosphate ; Positive_regulation PRKAB2 PLAT 24200922 2891723 This *induces* [AMPK] activation , membrane recruitment of GLUT1 , and GLUT1 mediated glucose uptake in astrocytes and endothelial cells . Positive_regulation PRKAB2 STK39 20029389 2192247 LKB1 is a that directly *activates* the energy sensor [AMP activated protein kinase (AMPK)] in response to bioenergetic stress , and mainly acts as a tumor suppressor that controls cell polarity and proliferation . Positive_regulation PRKAB2 TNF 17446186 1749523 also potently *stimulated* the phosphorylation of ERK1/2 and [AMPK] . Positive_regulation PRKAB2 TNF 17446186 1749531 Treatment with SB203580 decreased p38 MAPK phosphorylation back to the baseline and restored insulin sensitivity of IRS-1 tyrosine and Akt phosphorylation and eNOS activity in TNF-alpha treated bAECs without affecting *induced* ERK1/2 and [AMPK] phosphorylation . Positive_regulation PRKAB2 TNF 17446186 1749538 We conclude that in cultured bAECs , induces insulin resistance in the phosphatidylinositol 3-kinase/Akt/eNOS pathway via a p38 MAPK dependent mechanism and *enhances* ERK1/2 and [AMPK] phosphorylation independent of the p38 MAPK pathway . Positive_regulation PRKAB2 TNF 21427236 2412152 induced [AMPK] *activation* has been shown to be necessary for nuclear factor ?appa B ( NF-?B ) -induced inducible nitric oxide synthase expression and for blocking TNF-a induced apoptosis . Positive_regulation PRKAB2 TNFSF10 19197243 2049713 Interestingly , the induced [AMPK] *activation* is refractory to the depletion of the two known AMPK activating kinases , LKB1 and Ca ( 2+ ) /calmodulin dependent kinase kinase-beta , but depends on transforming growth factor-beta activating kinase 1 ( TAK1 ) and TAK1 binding subunit 2 . Positive_regulation PRKACB ADRB2 12114321 964028 In the heart , stimulation of , a prototypical GPCR , *activates* a tightly localized [protein kinase A (PKA)] signaling , which regulates substrates at cell surface membranes , bypassing cytosolic target proteins ( eg , phospholamban ) . Positive_regulation PRKACB ALOX5 20614517 2286500 In patients with DFS , the condition for wound process termination was decreased baseline iNOS activity and enhanced arginase-1 activity during [PKA] *stimulation* with the lower activity of <5-LO> , PDE , and PKS . Positive_regulation PRKACB CAPN8 23410952 2793849 In the process of validating this assay , we discovered that [PKA] activity is *regulated* by the protease . Positive_regulation PRKACB CCND1 16522728 1531467 We conclude that incretin induced beta-cell replication is dependent on [cAMP/PKA] , p42 MAPK and PI3K activities , which may *involve* transcriptional induction of . Positive_regulation PRKACB CTGF 16813525 1580683 Furthermore , we found that was *induced* by PTHrP through [PKA-] , PKC- , and ERK mediated pathways therein . Positive_regulation PRKACB CTGF 16813525 1580707 was critically involved in osteolytic metastasis and was *induced* by [PKA-] and PKC dependent activation of ERK1/2 signaling by PTHrP . Positive_regulation PRKACB EPHB2 12473665 1055939 However , PACAP induced GTP loading of Rap1 was not sufficient to account for ERK activation by PACAP because 1 ) PACAP elicited Rap1 GTP loading depended only on phospholipase C , whereas maximal stimulation of by PACAP also *required* the activity of [protein kinase A (PKA)] , protein kinase C ( PKC ) , and calcium dependent signaling ; Positive_regulation PRKACB EPHB2 17900862 1811336 The stearoylated Val12-Ser49 38-mer peptide enhanced the isoprenaline stimulated [PKA] phosphorylation of the beta ( 2 ) -adrenergic receptors ( beta ( 2 ) AR ) and its *activation* of , whilst the Glu27Ala peptide was ineffective in both these regards . Positive_regulation PRKACB EPHB2 20434519 2282550 Furthermore , in the presence of oocytes , the inhibition of endogenous FGF receptor signaling suppressed FSH- and forskolin induced progesterone and cAMP , showing that endogenous FGF system is involved in *activation* of FSH induced [cAMP-PKA] signaling via and SAPK/JNK . Positive_regulation PRKACB EPHB2 21701568 2505186 These findings demonstrate that SAA induced lipolysis is a result of downregulation of perilipin and *activation* of HSL via and [PKA] signaling pathways . Positive_regulation PRKACB EPHB2 22539851 2590214 Thus , in lesioned animals , Ga ( olf ) upregulation is critical for the *activation* by L-DOPA of D1R stimulated [cAMP/PKA] but not signaling . Positive_regulation PRKACB EPHB2 9808472 545223 Interestingly , the Ca2+ induced nuclear translocation of and Rsk2 to the nucleus *requires* [protein kinase A (PKA)] activation . Positive_regulation PRKACB GLP1R 21356521 2394823 activation by Exendin-4 ( Ex-4 ) *increased* [PKA] and MAPK activity and decreased phosphorylation of AMPK in NTS . Positive_regulation PRKACB GPR115 15499021 1325723 dependent *activation* of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Positive_regulation PRKACB GPR132 15499021 1325712 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Positive_regulation PRKACB GPR87 15499021 1325792 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Positive_regulation PRKACB MAP2K6 11918547 925621 Activation of [protein kinase A (PKA)] , however , lowered PAI-1 secretion induced by uPA and tPA , as a *result* of an inhibition of the PKC pathway and inhibition of Raf , and MAPK phosphorylations . Positive_regulation PRKACB PDE4B 21266552 2414458 The SAM mediated decrease in LPS-inducible up-regulation *resulted* in an increase in cellular cAMP levels and activation of cAMP dependent [protein kinase A (PKA)] , which plays an inhibitory role in LPS induced TNF production . Positive_regulation PRKACB PGC 22767158 2676385 hesperetin activates PI-3 K , [PKA] , PKC , ERK1 and CREB , and it *induces* PI-3 K , PKA , and seladin-1 via both ER and TrkA ; Positive_regulation PRKACB PLAT 18493852 1965437 To examine PKA involvement in the effects of db-cAMP on MMP-9 and tPA activity , we added the [PKA] inhibitors , H89 or rp-cAMP , along with db-cAMP , and they *inhibited* db-cAMP mediated changes in activity without affecting MMP-9 activity . Positive_regulation PRKACB SLCO2A1 21212407 2386319 This increase in aromatase was explained , at least in part , by reduced levels *leading* to enhanced PGE ( 2 ) ? cAMP ? [PKA] signaling . Positive_regulation PRKACB TNF 16754782 1599077 also *increased* [protein kinase A (PKA)] expression and cAMP levels , cyclooxygenase-2 (COX-2) expression , and activated productions of prostaglandin ( PG ) E2 and 6-keto-PGF1alpha ( stable PGI2 metabolite ) . Positive_regulation PRKACB TNF 16754782 1599085 It is suggested that *induced* increases of [PKA] expression and cAMP levels are mediated by releasing PGE2 and PGI2 , the activation products of COX-2 . Positive_regulation PRKACB TNF 19150610 2043121 Although H89 can inhibit both MSK1 and PKA , does not *activate* PKA ( EC 2.7.11.11 ) and as such [PKA] inhibition does not mediate H89 instigated repression of TNF stimulated gene expression . Positive_regulation PRKACB TNF 7476903 326658 When PGE2 was used to activate adenylyl cyclase , however , rolipram potentiated cAMP accumulation , [PKA] *activation* , and inhibition of generation . Positive_regulation PRKACG ADRB2 12114321 964029 In the heart , stimulation of , a prototypical GPCR , *activates* a tightly localized [protein kinase A (PKA)] signaling , which regulates substrates at cell surface membranes , bypassing cytosolic target proteins ( eg , phospholamban ) . Positive_regulation PRKACG ALOX5 20614517 2286501 In patients with DFS , the condition for wound process termination was decreased baseline iNOS activity and enhanced arginase-1 activity during [PKA] *stimulation* with the lower activity of <5-LO> , PDE , and PKS . Positive_regulation PRKACG CAPN8 23410952 2793863 In the process of validating this assay , we discovered that [PKA] activity is *regulated* by the protease . Positive_regulation PRKACG CCND1 16522728 1531468 We conclude that incretin induced beta-cell replication is dependent on [cAMP/PKA] , p42 MAPK and PI3K activities , which may *involve* transcriptional induction of . Positive_regulation PRKACG CTGF 16813525 1580685 Furthermore , we found that was *induced* by PTHrP through [PKA-] , PKC- , and ERK mediated pathways therein . Positive_regulation PRKACG CTGF 16813525 1580710 was critically involved in osteolytic metastasis and was *induced* by [PKA-] and PKC dependent activation of ERK1/2 signaling by PTHrP . Positive_regulation PRKACG EPHB2 12473665 1055941 However , PACAP induced GTP loading of Rap1 was not sufficient to account for ERK activation by PACAP because 1 ) PACAP elicited Rap1 GTP loading depended only on phospholipase C , whereas maximal stimulation of by PACAP also *required* the activity of [protein kinase A (PKA)] , protein kinase C ( PKC ) , and calcium dependent signaling ; Positive_regulation PRKACG EPHB2 17900862 1811338 The stearoylated Val12-Ser49 38-mer peptide enhanced the isoprenaline stimulated [PKA] phosphorylation of the beta ( 2 ) -adrenergic receptors ( beta ( 2 ) AR ) and its *activation* of , whilst the Glu27Ala peptide was ineffective in both these regards . Positive_regulation PRKACG EPHB2 20434519 2282551 Furthermore , in the presence of oocytes , the inhibition of endogenous FGF receptor signaling suppressed FSH- and forskolin induced progesterone and cAMP , showing that endogenous FGF system is involved in *activation* of FSH induced [cAMP-PKA] signaling via and SAPK/JNK . Positive_regulation PRKACG EPHB2 21701568 2505188 These findings demonstrate that SAA induced lipolysis is a result of downregulation of perilipin and *activation* of HSL via and [PKA] signaling pathways . Positive_regulation PRKACG EPHB2 22539851 2590215 Thus , in lesioned animals , Ga ( olf ) upregulation is critical for the *activation* by L-DOPA of D1R stimulated [cAMP/PKA] but not signaling . Positive_regulation PRKACG EPHB2 9808472 545225 Interestingly , the Ca2+ induced nuclear translocation of and Rsk2 to the nucleus *requires* [protein kinase A (PKA)] activation . Positive_regulation PRKACG GLP1R 21356521 2394824 activation by Exendin-4 ( Ex-4 ) *increased* [PKA] and MAPK activity and decreased phosphorylation of AMPK in NTS . Positive_regulation PRKACG GPR115 15499021 1325816 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Positive_regulation PRKACG GPR132 15499021 1325805 dependent *activation* of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Positive_regulation PRKACG GPR87 15499021 1325885 dependent *activation* of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Positive_regulation PRKACG MAP2K6 11918547 925628 Activation of [protein kinase A (PKA)] , however , lowered PAI-1 secretion induced by uPA and tPA , as a *result* of an inhibition of the PKC pathway and inhibition of Raf , and MAPK phosphorylations . Positive_regulation PRKACG PDE4B 21266552 2414459 The SAM mediated decrease in LPS-inducible up-regulation *resulted* in an increase in cellular cAMP levels and activation of cAMP dependent [protein kinase A (PKA)] , which plays an inhibitory role in LPS induced TNF production . Positive_regulation PRKACG PGC 22767158 2676391 hesperetin activates PI-3 K , [PKA] , PKC , ERK1 and CREB , and it *induces* PI-3 K , PKA , and seladin-1 via both ER and TrkA ; Positive_regulation PRKACG PLAT 18493852 1965438 To examine PKA involvement in the effects of db-cAMP on MMP-9 and tPA activity , we added the [PKA] inhibitors , H89 or rp-cAMP , along with db-cAMP , and they *inhibited* db-cAMP mediated changes in activity without affecting MMP-9 activity . Positive_regulation PRKACG SLCO2A1 21212407 2386320 This increase in aromatase was explained , at least in part , by reduced levels *leading* to enhanced PGE ( 2 ) ? cAMP ? [PKA] signaling . Positive_regulation PRKACG TNF 16754782 1599078 also *increased* [protein kinase A (PKA)] expression and cAMP levels , cyclooxygenase-2 (COX-2) expression , and activated productions of prostaglandin ( PG ) E2 and 6-keto-PGF1alpha ( stable PGI2 metabolite ) . Positive_regulation PRKACG TNF 16754782 1599087 It is suggested that *induced* increases of [PKA] expression and cAMP levels are mediated by releasing PGE2 and PGI2 , the activation products of COX-2 . Positive_regulation PRKACG TNF 19150610 2043122 Although H89 can inhibit both MSK1 and PKA , does not *activate* PKA ( EC 2.7.11.11 ) and as such [PKA] inhibition does not mediate H89 instigated repression of TNF stimulated gene expression . Positive_regulation PRKACG TNF 7476903 326659 When PGE2 was used to activate adenylyl cyclase , however , rolipram potentiated cAMP accumulation , [PKA] *activation* , and inhibition of generation . Positive_regulation PRKAG1 AXIN2 24093678 2852021 Importantly , adenovirus based knockdown of AXIN in the mouse liver impaired AMPK activation and caused exacerbated fatty liver after starvation , underscoring an essential *role* of in [AMPK] activation . Positive_regulation PRKAG1 C1QTNF1 22086915 2534481 In isolated soleus muscle , recombinant *activated* [AMPK] signaling to increase fatty acid oxidation ex vivo , an effect abrogated by an AMPK inhibitor . Positive_regulation PRKAG1 CCND1 24236567 2903153 We suggest that these tumours may arise through a mechanism involving ATP depletion , *activation* of [AMPK] , and induction of , and that this may be a unique pathway of tumour development that has the potential for therapeutic intervention in these rare tumours . Positive_regulation PRKAG1 EPHB2 19520853 2116131 *Activation* of by [AMPK] upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation PRKAG1 FAS 19477172 2097644 In the present study , we demonstrate that signaling in DU145 human prostate cancer cells *leads* to rapid activation of [AMP activated protein kinase (AMPK)] , which plays a major role in adaptive responses to ATP depleting conditions ; Positive_regulation PRKAG1 FAS 23349077 2754086 These results indicate that CDCQ prevented lipid accumulation by blocking the expression of SREBP-1c and through LKB1/SIRT1 and [AMPK] *activation* in HepG2 cells , suggesting that CDCQ plays a potential role in the prevention of lipogenesis by AMPK activation . Positive_regulation PRKAG1 FOXO1 19079687 2003235 Sepsis and [AMPK] *Activation* by AICAR Differentially Regulate , -3 and -4 mRNA in Striated Muscle . Positive_regulation PRKAG1 HRH1 24636512 2925644 These data suggest a time dependent change of signaling , where olanzapine *activates* [AMPK] by blocking the H1Rs and causing hyperphagia in the acute phase . Positive_regulation PRKAG1 IFI27 18701472 1950396 Cytoplasmic localization of p27 in Tsc2-null cells was reversible pharmacologically using inhibitors of the LKB1/AMPK pathway , and localization of to the cytoplasm could be *induced* directly by activating AMPK physiologically ( glucose deprivation ) or genetically ( constitutively active [AMPK] ) in Tsc2-proficient cells . Positive_regulation PRKAG1 MAP2K6 17728396 1817176 Taken together , our studies identify novel links between the physiological state of the cell , the *activation* of -- > ERK1/2 signaling , and the nucleocytoplasmic distribution of [AMPK] . Positive_regulation PRKAG1 MAP2K6 19520853 2116137 *Activation* of by [AMPK] upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation PRKAG1 MMP28 24255018 2904413 Adiponectin *mediated* [APPL1-AMPK] signaling induces cell migration , activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation PRKAG1 MMP7 24255018 2904428 Adiponectin *mediated* [APPL1-AMPK] signaling induces cell migration , activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation PRKAG1 PGC 21187426 2378909 Overexpression of in TKO MEFs elevated ATP levels and *inhibited* the activation of [AMPK] . Positive_regulation PRKAG1 PGC 21803289 2462293 Deletion of mIndy in mice ( mINDY ( -/- ) mice ) reduces hepatocellular ATP/ADP ratio , activates hepatic [AMPK] , *induces* , inhibits ACC-2 , and reduces SREBP-1c levels . Positive_regulation PRKAG1 PGC 21862727 2510299 [AMPK] phosphorylation increased to a greater extent in the R-leg , and AICAR stimulation of cultured human myotubes *induced* the expression of PGC-1a-a and . Positive_regulation PRKAG1 PGC 23090186 2717192 Resveratrol also lowered the NEFA and triacylglycerol content of the kidney , and this action was related to increases in the phosphorylation of [AMPK] and the *activation* of signalling and of the key downstream effectors , the PPARa-oestrogen related receptor ( ERR ) -1a-sterol regulatory element binding protein 1 ( SREBP1 ) . Positive_regulation PRKAG1 PGC 23090186 2717216 Resveratrol prevented high-glucose induced oxidative stress and apoptosis in cultured mesangial cells through the phosphorylation of [AMPK] and *activation* of signalling and the downstream effectors , PPARa-ERR-1a-SREBP1 . Positive_regulation PRKAG1 PGC 23090186 2717240 The results suggest that resveratrol prevents diabetic nephropathy in db/db mice by the phosphorylation of [AMPK] and *activation* of signalling , which appear to prevent lipotoxicity related apoptosis and oxidative stress in the kidney . Positive_regulation PRKAG1 PGC 23523698 2794270 Erythropoietin also increases [AMPK] , which *induces* and stimulates slow oxidative fiber formation . Positive_regulation PRKAG1 PLAT 23562854 2778020 Glucose deprivation induced activation of PI3K-Akt-GSK3ß , p38 and [AMPK] , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation PRKAG1 PLAT 23881246 2861374 Mass spectrometry and immunohistochemical studies show that the release of this in the synaptic space *induces* [AMPK] activation in the postsynaptic terminal , and an AMPK mediated increase in neuronal uptake of glucose and neuronal adenosine 5 ' ( tetrahydrogen triphosphate ; Positive_regulation PRKAG1 PLAT 24200922 2891724 This *induces* [AMPK] activation , membrane recruitment of GLUT1 , and GLUT1 mediated glucose uptake in astrocytes and endothelial cells . Positive_regulation PRKAG1 STK39 20029389 2192262 LKB1 is a that directly *activates* the energy sensor [AMP activated protein kinase (AMPK)] in response to bioenergetic stress , and mainly acts as a tumor suppressor that controls cell polarity and proliferation . Positive_regulation PRKAG1 TNF 17446186 1749524 also potently *stimulated* the phosphorylation of ERK1/2 and [AMPK] . Positive_regulation PRKAG1 TNF 17446186 1749532 Treatment with SB203580 decreased p38 MAPK phosphorylation back to the baseline and restored insulin sensitivity of IRS-1 tyrosine and Akt phosphorylation and eNOS activity in TNF-alpha treated bAECs without affecting *induced* ERK1/2 and [AMPK] phosphorylation . Positive_regulation PRKAG1 TNF 17446186 1749539 We conclude that in cultured bAECs , induces insulin resistance in the phosphatidylinositol 3-kinase/Akt/eNOS pathway via a p38 MAPK dependent mechanism and *enhances* ERK1/2 and [AMPK] phosphorylation independent of the p38 MAPK pathway . Positive_regulation PRKAG1 TNF 21427236 2412153 *induced* [AMPK] activation has been shown to be necessary for nuclear factor ?appa B ( NF-?B ) -induced inducible nitric oxide synthase expression and for blocking TNF-a induced apoptosis . Positive_regulation PRKAG1 TNFSF10 19197243 2049714 Interestingly , the *induced* [AMPK] activation is refractory to the depletion of the two known AMPK activating kinases , LKB1 and Ca ( 2+ ) /calmodulin dependent kinase kinase-beta , but depends on transforming growth factor-beta activating kinase 1 ( TAK1 ) and TAK1 binding subunit 2 . Positive_regulation PRKAG2 AXIN2 24093678 2852023 Importantly , adenovirus based knockdown of AXIN in the mouse liver impaired AMPK activation and caused exacerbated fatty liver after starvation , underscoring an essential *role* of in [AMPK] activation . Positive_regulation PRKAG2 C1QTNF1 22086915 2534482 In isolated soleus muscle , recombinant *activated* [AMPK] signaling to increase fatty acid oxidation ex vivo , an effect abrogated by an AMPK inhibitor . Positive_regulation PRKAG2 CCND1 24236567 2903154 We suggest that these tumours may arise through a mechanism involving ATP depletion , *activation* of [AMPK] , and induction of , and that this may be a unique pathway of tumour development that has the potential for therapeutic intervention in these rare tumours . Positive_regulation PRKAG2 EPHB2 19520853 2116139 *Activation* of by [AMPK] upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation PRKAG2 FAS 19477172 2097645 In the present study , we demonstrate that signaling in DU145 human prostate cancer cells *leads* to rapid activation of [AMP activated protein kinase (AMPK)] , which plays a major role in adaptive responses to ATP depleting conditions ; Positive_regulation PRKAG2 FAS 23349077 2754090 These results indicate that CDCQ prevented lipid accumulation by blocking the expression of SREBP-1c and through LKB1/SIRT1 and [AMPK] *activation* in HepG2 cells , suggesting that CDCQ plays a potential role in the prevention of lipogenesis by AMPK activation . Positive_regulation PRKAG2 FOXO1 19079687 2003236 Sepsis and [AMPK] *Activation* by AICAR Differentially Regulate , -3 and -4 mRNA in Striated Muscle . Positive_regulation PRKAG2 HRH1 24636512 2925645 These data suggest a time dependent change of signaling , where olanzapine *activates* [AMPK] by blocking the H1Rs and causing hyperphagia in the acute phase . Positive_regulation PRKAG2 IFI27 18701472 1950398 Cytoplasmic localization of p27 in Tsc2-null cells was reversible pharmacologically using inhibitors of the LKB1/AMPK pathway , and localization of to the cytoplasm could be *induced* directly by activating AMPK physiologically ( glucose deprivation ) or genetically ( constitutively active [AMPK] ) in Tsc2-proficient cells . Positive_regulation PRKAG2 MAP2K6 17728396 1817183 Taken together , our studies identify novel links between the physiological state of the cell , the *activation* of -- > ERK1/2 signaling , and the nucleocytoplasmic distribution of [AMPK] . Positive_regulation PRKAG2 MAP2K6 19520853 2116145 *Activation* of by [AMPK] upon autophagy stimuli disassembled mTORC1 via binding to and activating TSC but disassembled mTORC2 independently of TSC . Positive_regulation PRKAG2 MMP28 24255018 2904436 Adiponectin *mediated* [APPL1-AMPK] signaling induces cell migration , activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation PRKAG2 MMP7 24255018 2904451 Adiponectin *mediated* [APPL1-AMPK] signaling induces cell migration , activation , and collagen remodeling in cardiac fibroblasts . Positive_regulation PRKAG2 PGC 21187426 2378910 Overexpression of in TKO MEFs elevated ATP levels and *inhibited* the activation of [AMPK] . Positive_regulation PRKAG2 PGC 21803289 2462294 Deletion of mIndy in mice ( mINDY ( -/- ) mice ) reduces hepatocellular ATP/ADP ratio , activates hepatic [AMPK] , *induces* , inhibits ACC-2 , and reduces SREBP-1c levels . Positive_regulation PRKAG2 PGC 21862727 2510300 [AMPK] phosphorylation increased to a greater extent in the R-leg , and AICAR stimulation of cultured human myotubes *induced* the expression of and PGC-1a-b . Positive_regulation PRKAG2 PGC 23090186 2717194 Resveratrol also lowered the NEFA and triacylglycerol content of the kidney , and this action was related to increases in the phosphorylation of [AMPK] and the *activation* of signalling and of the key downstream effectors , the PPARa-oestrogen related receptor ( ERR ) -1a-sterol regulatory element binding protein 1 ( SREBP1 ) . Positive_regulation PRKAG2 PGC 23090186 2717218 Resveratrol prevented high-glucose induced oxidative stress and apoptosis in cultured mesangial cells through the phosphorylation of [AMPK] and *activation* of signalling and the downstream effectors , PPARa-ERR-1a-SREBP1 . Positive_regulation PRKAG2 PGC 23090186 2717242 The results suggest that resveratrol prevents diabetic nephropathy in db/db mice by the phosphorylation of [AMPK] and *activation* of signalling , which appear to prevent lipotoxicity related apoptosis and oxidative stress in the kidney . Positive_regulation PRKAG2 PGC 23523698 2794272 Erythropoietin also increases [AMPK] , which *induces* and stimulates slow oxidative fiber formation . Positive_regulation PRKAG2 PLAT 23562854 2778021 Glucose deprivation induced activation of PI3K-Akt-GSK3ß , p38 and [AMPK] , and inhibition of these pathways using LY294002 , SB203580 and compound C significantly *inhibited* glucose deprivation induced down-regulation , demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes . Positive_regulation PRKAG2 PLAT 23881246 2861375 Mass spectrometry and immunohistochemical studies show that the release of this in the synaptic space *induces* [AMPK] activation in the postsynaptic terminal , and an AMPK mediated increase in neuronal uptake of glucose and neuronal adenosine 5 ' ( tetrahydrogen triphosphate ; Positive_regulation PRKAG2 PLAT 24200922 2891725 This *induces* [AMPK] activation , membrane recruitment of GLUT1 , and GLUT1 mediated glucose uptake in astrocytes and endothelial cells . Positive_regulation PRKAG2 STK39 20029389 2192277 LKB1 is a that directly *activates* the energy sensor [AMP activated protein kinase (AMPK)] in response to bioenergetic stress , and mainly acts as a tumor suppressor that controls cell polarity and proliferation . Positive_regulation PRKAG2 TNF 17446186 1749525 also potently *stimulated* the phosphorylation of ERK1/2 and [AMPK] . Positive_regulation PRKAG2 TNF 17446186 1749533 Treatment with SB203580 decreased p38 MAPK phosphorylation back to the baseline and restored insulin sensitivity of IRS-1 tyrosine and Akt phosphorylation and eNOS activity in TNF-alpha treated bAECs without affecting *induced* ERK1/2 and [AMPK] phosphorylation . Positive_regulation PRKAG2 TNF 17446186 1749540 We conclude that in cultured bAECs , induces insulin resistance in the phosphatidylinositol 3-kinase/Akt/eNOS pathway via a p38 MAPK dependent mechanism and *enhances* ERK1/2 and [AMPK] phosphorylation independent of the p38 MAPK pathway . Positive_regulation PRKAG2 TNF 21427236 2412154 induced [AMPK] *activation* has been shown to be necessary for nuclear factor ?appa B ( NF-?B ) -induced inducible nitric oxide synthase expression and for blocking TNF-a induced apoptosis . Positive_regulation PRKAG2 TNFSF10 19197243 2049715 Interestingly , the induced [AMPK] *activation* is refractory to the depletion of the two known AMPK activating kinases , LKB1 and Ca ( 2+ ) /calmodulin dependent kinase kinase-beta , but depends on transforming growth factor-beta activating kinase 1 ( TAK1 ) and TAK1 binding subunit 2 . Positive_regulation PRKAR1A ADRB2 12114321 964030 In the heart , stimulation of , a prototypical GPCR , *activates* a tightly localized [protein kinase A (PKA)] signaling , which regulates substrates at cell surface membranes , bypassing cytosolic target proteins ( eg , phospholamban ) . Positive_regulation PRKAR1A ALOX5 20614517 2286502 In patients with DFS , the condition for wound process termination was decreased baseline iNOS activity and enhanced arginase-1 activity during [PKA] *stimulation* with the lower activity of <5-LO> , PDE , and PKS . Positive_regulation PRKAR1A CAPN8 23410952 2793877 In the process of validating this assay , we discovered that [PKA] activity is *regulated* by the protease . Positive_regulation PRKAR1A CCND1 16522728 1531469 We conclude that incretin induced beta-cell replication is dependent on [cAMP/PKA] , p42 MAPK and PI3K activities , which may *involve* transcriptional induction of . Positive_regulation PRKAR1A CTGF 16813525 1580687 Furthermore , we found that was *induced* by PTHrP through [PKA-] , PKC- , and ERK mediated pathways therein . Positive_regulation PRKAR1A CTGF 16813525 1580713 was critically involved in osteolytic metastasis and was *induced* by [PKA-] and PKC dependent activation of ERK1/2 signaling by PTHrP . Positive_regulation PRKAR1A EPHB2 12473665 1055943 However , PACAP induced GTP loading of Rap1 was not sufficient to account for ERK activation by PACAP because 1 ) PACAP elicited Rap1 GTP loading depended only on phospholipase C , whereas maximal stimulation of by PACAP also *required* the activity of [protein kinase A (PKA)] , protein kinase C ( PKC ) , and calcium dependent signaling ; Positive_regulation PRKAR1A EPHB2 17900862 1811340 The stearoylated Val12-Ser49 38-mer peptide enhanced the isoprenaline stimulated [PKA] phosphorylation of the beta ( 2 ) -adrenergic receptors ( beta ( 2 ) AR ) and its *activation* of , whilst the Glu27Ala peptide was ineffective in both these regards . Positive_regulation PRKAR1A EPHB2 20434519 2282552 Furthermore , in the presence of oocytes , the inhibition of endogenous FGF receptor signaling suppressed FSH- and forskolin induced progesterone and cAMP , showing that endogenous FGF system is involved in *activation* of FSH induced [cAMP-PKA] signaling via and SAPK/JNK . Positive_regulation PRKAR1A EPHB2 21701568 2505190 These findings demonstrate that SAA induced lipolysis is a result of downregulation of perilipin and *activation* of HSL via and [PKA] signaling pathways . Positive_regulation PRKAR1A EPHB2 22539851 2590216 Thus , in lesioned animals , Ga ( olf ) upregulation is critical for the *activation* by L-DOPA of D1R stimulated [cAMP/PKA] but not signaling . Positive_regulation PRKAR1A EPHB2 9808472 545227 Interestingly , the Ca2+ induced nuclear translocation of and Rsk2 to the nucleus *requires* [protein kinase A (PKA)] activation . Positive_regulation PRKAR1A GLP1R 21356521 2394825 activation by Exendin-4 ( Ex-4 ) *increased* [PKA] and MAPK activity and decreased phosphorylation of AMPK in NTS . Positive_regulation PRKAR1A GPR115 15499021 1325909 dependent *activation* of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Positive_regulation PRKAR1A GPR132 15499021 1325898 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Positive_regulation PRKAR1A GPR87 15499021 1325978 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Positive_regulation PRKAR1A MAP2K6 11918547 925635 Activation of [protein kinase A (PKA)] , however , lowered PAI-1 secretion induced by uPA and tPA , as a *result* of an inhibition of the PKC pathway and inhibition of Raf , and MAPK phosphorylations . Positive_regulation PRKAR1A PDE4B 21266552 2414460 The SAM mediated decrease in LPS-inducible up-regulation *resulted* in an increase in cellular cAMP levels and activation of cAMP dependent [protein kinase A (PKA)] , which plays an inhibitory role in LPS induced TNF production . Positive_regulation PRKAR1A PGC 22767158 2676397 hesperetin activates PI-3 K , [PKA] , PKC , ERK1 and CREB , and it *induces* PI-3 K , PKA , and seladin-1 via both ER and TrkA ; Positive_regulation PRKAR1A PLAT 18493852 1965439 To examine PKA involvement in the effects of db-cAMP on MMP-9 and tPA activity , we added the [PKA] inhibitors , H89 or rp-cAMP , along with db-cAMP , and they *inhibited* db-cAMP mediated changes in activity without affecting MMP-9 activity . Positive_regulation PRKAR1A SLCO2A1 21212407 2386321 This increase in aromatase was explained , at least in part , by reduced levels *leading* to enhanced PGE ( 2 ) ? cAMP ? [PKA] signaling . Positive_regulation PRKAR1A TNF 16754782 1599079 also *increased* [protein kinase A (PKA)] expression and cAMP levels , cyclooxygenase-2 (COX-2) expression , and activated productions of prostaglandin ( PG ) E2 and 6-keto-PGF1alpha ( stable PGI2 metabolite ) . Positive_regulation PRKAR1A TNF 16754782 1599089 It is suggested that *induced* increases of [PKA] expression and cAMP levels are mediated by releasing PGE2 and PGI2 , the activation products of COX-2 . Positive_regulation PRKAR1A TNF 19150610 2043123 Although H89 can inhibit both MSK1 and PKA , does not *activate* PKA ( EC 2.7.11.11 ) and as such [PKA] inhibition does not mediate H89 instigated repression of TNF stimulated gene expression . Positive_regulation PRKAR1A TNF 7476903 326660 When PGE2 was used to activate adenylyl cyclase , however , rolipram potentiated cAMP accumulation , [PKA] *activation* , and inhibition of generation . Positive_regulation PRKAR1B ADRB2 12114321 964031 In the heart , stimulation of , a prototypical GPCR , *activates* a tightly localized [protein kinase A (PKA)] signaling , which regulates substrates at cell surface membranes , bypassing cytosolic target proteins ( eg , phospholamban ) . Positive_regulation PRKAR1B ALOX5 20614517 2286503 In patients with DFS , the condition for wound process termination was decreased baseline iNOS activity and enhanced arginase-1 activity during [PKA] *stimulation* with the lower activity of <5-LO> , PDE , and PKS . Positive_regulation PRKAR1B CAPN8 23410952 2793891 In the process of validating this assay , we discovered that [PKA] activity is *regulated* by the protease . Positive_regulation PRKAR1B CCND1 16522728 1531470 We conclude that incretin induced beta-cell replication is dependent on [cAMP/PKA] , p42 MAPK and PI3K activities , which may *involve* transcriptional induction of . Positive_regulation PRKAR1B CTGF 16813525 1580689 Furthermore , we found that was *induced* by PTHrP through [PKA-] , PKC- , and ERK mediated pathways therein . Positive_regulation PRKAR1B CTGF 16813525 1580716 was critically involved in osteolytic metastasis and was *induced* by [PKA-] and PKC dependent activation of ERK1/2 signaling by PTHrP . Positive_regulation PRKAR1B EPHB2 12473665 1055945 However , PACAP induced GTP loading of Rap1 was not sufficient to account for ERK activation by PACAP because 1 ) PACAP elicited Rap1 GTP loading depended only on phospholipase C , whereas maximal stimulation of by PACAP also *required* the activity of [protein kinase A (PKA)] , protein kinase C ( PKC ) , and calcium dependent signaling ; Positive_regulation PRKAR1B EPHB2 17900862 1811342 The stearoylated Val12-Ser49 38-mer peptide enhanced the isoprenaline stimulated [PKA] phosphorylation of the beta ( 2 ) -adrenergic receptors ( beta ( 2 ) AR ) and its *activation* of , whilst the Glu27Ala peptide was ineffective in both these regards . Positive_regulation PRKAR1B EPHB2 20434519 2282553 Furthermore , in the presence of oocytes , the inhibition of endogenous FGF receptor signaling suppressed FSH- and forskolin induced progesterone and cAMP , showing that endogenous FGF system is involved in *activation* of FSH induced [cAMP-PKA] signaling via and SAPK/JNK . Positive_regulation PRKAR1B EPHB2 21701568 2505192 These findings demonstrate that SAA induced lipolysis is a result of downregulation of perilipin and *activation* of HSL via and [PKA] signaling pathways . Positive_regulation PRKAR1B EPHB2 22539851 2590217 Thus , in lesioned animals , Ga ( olf ) upregulation is critical for the *activation* by L-DOPA of D1R stimulated [cAMP/PKA] but not signaling . Positive_regulation PRKAR1B EPHB2 9808472 545229 Interestingly , the Ca2+ induced nuclear translocation of and Rsk2 to the nucleus *requires* [protein kinase A (PKA)] activation . Positive_regulation PRKAR1B GLP1R 21356521 2394826 activation by Exendin-4 ( Ex-4 ) *increased* [PKA] and MAPK activity and decreased phosphorylation of AMPK in NTS . Positive_regulation PRKAR1B GPR115 15499021 1326002 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Positive_regulation PRKAR1B GPR132 15499021 1325991 dependent *activation* of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Positive_regulation PRKAR1B GPR87 15499021 1326071 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Positive_regulation PRKAR1B MAP2K6 11918547 925642 Activation of [protein kinase A (PKA)] , however , lowered PAI-1 secretion induced by uPA and tPA , as a *result* of an inhibition of the PKC pathway and inhibition of Raf , and MAPK phosphorylations . Positive_regulation PRKAR1B PDE4B 21266552 2414461 The SAM mediated decrease in LPS-inducible up-regulation *resulted* in an increase in cellular cAMP levels and activation of cAMP dependent [protein kinase A (PKA)] , which plays an inhibitory role in LPS induced TNF production . Positive_regulation PRKAR1B PGC 22767158 2676403 hesperetin activates PI-3 K , [PKA] , PKC , ERK1 and CREB , and it *induces* PI-3 K , PKA , and seladin-1 via both ER and TrkA ; Positive_regulation PRKAR1B PLAT 18493852 1965440 To examine PKA involvement in the effects of db-cAMP on MMP-9 and tPA activity , we added the [PKA] inhibitors , H89 or rp-cAMP , along with db-cAMP , and they *inhibited* db-cAMP mediated changes in activity without affecting MMP-9 activity . Positive_regulation PRKAR1B SLCO2A1 21212407 2386322 This increase in aromatase was explained , at least in part , by reduced levels *leading* to enhanced PGE ( 2 ) ? cAMP ? [PKA] signaling . Positive_regulation PRKAR1B TNF 16754782 1599080 also *increased* [protein kinase A (PKA)] expression and cAMP levels , cyclooxygenase-2 (COX-2) expression , and activated productions of prostaglandin ( PG ) E2 and 6-keto-PGF1alpha ( stable PGI2 metabolite ) . Positive_regulation PRKAR1B TNF 16754782 1599091 It is suggested that *induced* increases of [PKA] expression and cAMP levels are mediated by releasing PGE2 and PGI2 , the activation products of COX-2 . Positive_regulation PRKAR1B TNF 19150610 2043124 Although H89 can inhibit both MSK1 and PKA , does not *activate* PKA ( EC 2.7.11.11 ) and as such [PKA] inhibition does not mediate H89 instigated repression of TNF stimulated gene expression . Positive_regulation PRKAR1B TNF 7476903 326661 When PGE2 was used to activate adenylyl cyclase , however , rolipram potentiated cAMP accumulation , [PKA] *activation* , and inhibition of generation . Positive_regulation PRKAR2A ADRB2 12114321 964032 In the heart , stimulation of , a prototypical GPCR , *activates* a tightly localized [protein kinase A (PKA)] signaling , which regulates substrates at cell surface membranes , bypassing cytosolic target proteins ( eg , phospholamban ) . Positive_regulation PRKAR2A ALOX5 20614517 2286504 In patients with DFS , the condition for wound process termination was decreased baseline iNOS activity and enhanced arginase-1 activity during [PKA] *stimulation* with the lower activity of <5-LO> , PDE , and PKS . Positive_regulation PRKAR2A CAPN8 23410952 2793905 In the process of validating this assay , we discovered that [PKA] activity is *regulated* by the protease . Positive_regulation PRKAR2A CCND1 16522728 1531471 We conclude that incretin induced beta-cell replication is dependent on [cAMP/PKA] , p42 MAPK and PI3K activities , which may *involve* transcriptional induction of . Positive_regulation PRKAR2A CTGF 16813525 1580691 Furthermore , we found that was *induced* by PTHrP through [PKA-] , PKC- , and ERK mediated pathways therein . Positive_regulation PRKAR2A CTGF 16813525 1580719 was critically involved in osteolytic metastasis and was *induced* by [PKA-] and PKC dependent activation of ERK1/2 signaling by PTHrP . Positive_regulation PRKAR2A EPHB2 12473665 1055947 However , PACAP induced GTP loading of Rap1 was not sufficient to account for ERK activation by PACAP because 1 ) PACAP elicited Rap1 GTP loading depended only on phospholipase C , whereas maximal stimulation of by PACAP also *required* the activity of [protein kinase A (PKA)] , protein kinase C ( PKC ) , and calcium dependent signaling ; Positive_regulation PRKAR2A EPHB2 17900862 1811344 The stearoylated Val12-Ser49 38-mer peptide enhanced the isoprenaline stimulated [PKA] phosphorylation of the beta ( 2 ) -adrenergic receptors ( beta ( 2 ) AR ) and its *activation* of , whilst the Glu27Ala peptide was ineffective in both these regards . Positive_regulation PRKAR2A EPHB2 20434519 2282554 Furthermore , in the presence of oocytes , the inhibition of endogenous FGF receptor signaling suppressed FSH- and forskolin induced progesterone and cAMP , showing that endogenous FGF system is involved in *activation* of FSH induced [cAMP-PKA] signaling via and SAPK/JNK . Positive_regulation PRKAR2A EPHB2 21701568 2505194 These findings demonstrate that SAA induced lipolysis is a result of downregulation of perilipin and *activation* of HSL via and [PKA] signaling pathways . Positive_regulation PRKAR2A EPHB2 22539851 2590218 Thus , in lesioned animals , Ga ( olf ) upregulation is critical for the *activation* by L-DOPA of D1R stimulated [cAMP/PKA] but not signaling . Positive_regulation PRKAR2A EPHB2 9808472 545231 Interestingly , the Ca2+ induced nuclear translocation of and Rsk2 to the nucleus *requires* [protein kinase A (PKA)] activation . Positive_regulation PRKAR2A GLP1R 21356521 2394827 activation by Exendin-4 ( Ex-4 ) *increased* [PKA] and MAPK activity and decreased phosphorylation of AMPK in NTS . Positive_regulation PRKAR2A GPR115 15499021 1326095 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Positive_regulation PRKAR2A GPR132 15499021 1326084 dependent *activation* of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Positive_regulation PRKAR2A GPR87 15499021 1326164 dependent *activation* of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Positive_regulation PRKAR2A MAP2K6 11918547 925649 Activation of [protein kinase A (PKA)] , however , lowered PAI-1 secretion induced by uPA and tPA , as a *result* of an inhibition of the PKC pathway and inhibition of Raf , and MAPK phosphorylations . Positive_regulation PRKAR2A PDE4B 21266552 2414462 The SAM mediated decrease in LPS-inducible up-regulation *resulted* in an increase in cellular cAMP levels and activation of cAMP dependent [protein kinase A (PKA)] , which plays an inhibitory role in LPS induced TNF production . Positive_regulation PRKAR2A PGC 22767158 2676409 hesperetin activates PI-3 K , [PKA] , PKC , ERK1 and CREB , and it *induces* PI-3 K , PKA , and seladin-1 via both ER and TrkA ; Positive_regulation PRKAR2A PLAT 18493852 1965441 To examine PKA involvement in the effects of db-cAMP on MMP-9 and tPA activity , we added the [PKA] inhibitors , H89 or rp-cAMP , along with db-cAMP , and they *inhibited* db-cAMP mediated changes in activity without affecting MMP-9 activity . Positive_regulation PRKAR2A SLCO2A1 21212407 2386323 This increase in aromatase was explained , at least in part , by reduced levels *leading* to enhanced PGE ( 2 ) ? cAMP ? [PKA] signaling . Positive_regulation PRKAR2A TNF 16754782 1599081 also *increased* [protein kinase A (PKA)] expression and cAMP levels , cyclooxygenase-2 (COX-2) expression , and activated productions of prostaglandin ( PG ) E2 and 6-keto-PGF1alpha ( stable PGI2 metabolite ) . Positive_regulation PRKAR2A TNF 16754782 1599093 It is suggested that *induced* increases of [PKA] expression and cAMP levels are mediated by releasing PGE2 and PGI2 , the activation products of COX-2 . Positive_regulation PRKAR2A TNF 19150610 2043125 Although H89 can inhibit both MSK1 and PKA , does not *activate* PKA ( EC 2.7.11.11 ) and as such [PKA] inhibition does not mediate H89 instigated repression of TNF stimulated gene expression . Positive_regulation PRKAR2A TNF 7476903 326662 When PGE2 was used to activate adenylyl cyclase , however , rolipram potentiated cAMP accumulation , [PKA] *activation* , and inhibition of generation . Positive_regulation PRKAR2B ADRB2 12114321 964033 In the heart , stimulation of , a prototypical GPCR , *activates* a tightly localized [protein kinase A (PKA)] signaling , which regulates substrates at cell surface membranes , bypassing cytosolic target proteins ( eg , phospholamban ) . Positive_regulation PRKAR2B ALOX5 20614517 2286505 In patients with DFS , the condition for wound process termination was decreased baseline iNOS activity and enhanced arginase-1 activity during [PKA] *stimulation* with the lower activity of <5-LO> , PDE , and PKS . Positive_regulation PRKAR2B CAPN8 23410952 2793919 In the process of validating this assay , we discovered that [PKA] activity is *regulated* by the protease . Positive_regulation PRKAR2B CCND1 16522728 1531472 We conclude that incretin induced beta-cell replication is dependent on [cAMP/PKA] , p42 MAPK and PI3K activities , which may *involve* transcriptional induction of . Positive_regulation PRKAR2B CTGF 16813525 1580693 Furthermore , we found that was *induced* by PTHrP through [PKA-] , PKC- , and ERK mediated pathways therein . Positive_regulation PRKAR2B CTGF 16813525 1580722 was critically involved in osteolytic metastasis and was *induced* by [PKA-] and PKC dependent activation of ERK1/2 signaling by PTHrP . Positive_regulation PRKAR2B EPHB2 12473665 1055949 However , PACAP induced GTP loading of Rap1 was not sufficient to account for ERK activation by PACAP because 1 ) PACAP elicited Rap1 GTP loading depended only on phospholipase C , whereas maximal stimulation of by PACAP also *required* the activity of [protein kinase A (PKA)] , protein kinase C ( PKC ) , and calcium dependent signaling ; Positive_regulation PRKAR2B EPHB2 17900862 1811346 The stearoylated Val12-Ser49 38-mer peptide enhanced the isoprenaline stimulated [PKA] phosphorylation of the beta ( 2 ) -adrenergic receptors ( beta ( 2 ) AR ) and its *activation* of , whilst the Glu27Ala peptide was ineffective in both these regards . Positive_regulation PRKAR2B EPHB2 20434519 2282555 Furthermore , in the presence of oocytes , the inhibition of endogenous FGF receptor signaling suppressed FSH- and forskolin induced progesterone and cAMP , showing that endogenous FGF system is involved in *activation* of FSH induced [cAMP-PKA] signaling via and SAPK/JNK . Positive_regulation PRKAR2B EPHB2 21701568 2505196 These findings demonstrate that SAA induced lipolysis is a result of downregulation of perilipin and *activation* of HSL via and [PKA] signaling pathways . Positive_regulation PRKAR2B EPHB2 22539851 2590219 Thus , in lesioned animals , Ga ( olf ) upregulation is critical for the *activation* by L-DOPA of D1R stimulated [cAMP/PKA] but not signaling . Positive_regulation PRKAR2B EPHB2 9808472 545233 Interestingly , the Ca2+ induced nuclear translocation of and Rsk2 to the nucleus *requires* [protein kinase A (PKA)] activation . Positive_regulation PRKAR2B GLP1R 21356521 2394828 activation by Exendin-4 ( Ex-4 ) *increased* [PKA] and MAPK activity and decreased phosphorylation of AMPK in NTS . Positive_regulation PRKAR2B GPR115 15499021 1326188 dependent *activation* of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Positive_regulation PRKAR2B GPR132 15499021 1326177 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Positive_regulation PRKAR2B GPR87 15499021 1326257 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Positive_regulation PRKAR2B MAP2K6 11918547 925656 Activation of [protein kinase A (PKA)] , however , lowered PAI-1 secretion induced by uPA and tPA , as a *result* of an inhibition of the PKC pathway and inhibition of Raf , and MAPK phosphorylations . Positive_regulation PRKAR2B PDE4B 21266552 2414463 The SAM mediated decrease in LPS-inducible up-regulation *resulted* in an increase in cellular cAMP levels and activation of cAMP dependent [protein kinase A (PKA)] , which plays an inhibitory role in LPS induced TNF production . Positive_regulation PRKAR2B PGC 22767158 2676415 hesperetin activates PI-3 K , [PKA] , PKC , ERK1 and CREB , and it *induces* PI-3 K , PKA , and seladin-1 via both ER and TrkA ; Positive_regulation PRKAR2B PLAT 18493852 1965442 To examine PKA involvement in the effects of db-cAMP on MMP-9 and tPA activity , we added the [PKA] inhibitors , H89 or rp-cAMP , along with db-cAMP , and they *inhibited* db-cAMP mediated changes in activity without affecting MMP-9 activity . Positive_regulation PRKAR2B SLCO2A1 21212407 2386324 This increase in aromatase was explained , at least in part , by reduced levels *leading* to enhanced PGE ( 2 ) ? cAMP ? [PKA] signaling . Positive_regulation PRKAR2B TNF 16754782 1599082 also *increased* [protein kinase A (PKA)] expression and cAMP levels , cyclooxygenase-2 (COX-2) expression , and activated productions of prostaglandin ( PG ) E2 and 6-keto-PGF1alpha ( stable PGI2 metabolite ) . Positive_regulation PRKAR2B TNF 16754782 1599095 It is suggested that *induced* increases of [PKA] expression and cAMP levels are mediated by releasing PGE2 and PGI2 , the activation products of COX-2 . Positive_regulation PRKAR2B TNF 19150610 2043126 Although H89 can inhibit both MSK1 and PKA , does not *activate* PKA ( EC 2.7.11.11 ) and as such [PKA] inhibition does not mediate H89 instigated repression of TNF stimulated gene expression . Positive_regulation PRKAR2B TNF 7476903 326663 When PGE2 was used to activate adenylyl cyclase , however , rolipram potentiated cAMP accumulation , [PKA] *activation* , and inhibition of generation . Positive_regulation PRKCA ALOX5 16998804 1666300 In particular , the lipid messenger is metabolised by <5-lipoxygenase (5-LO)> to 5-hydroxyeicosatetraenoic acid and *causes* the mitochondrial translocation of [protein kinase Calpha (PKCalpha)] , an event associated with the cytosolic accumulation of Bad and Bax . Positive_regulation PRKCA CAPN8 10868631 706547 We investigated the mechanisms of cytoprotection by PGE1 , focusing on the elevation of intracellular calcium ( [ Ca2+ ] i ) , activation of calpain-mu , and *mediated* activation of [protein kinase C-alpha (PKC-alpha)] . Positive_regulation PRKCA EPHB2 12676358 1076765 *dependent* activation of only [PKCalpha] was observed in immunoprecipitates obtained from 5-HT(1A) agonist treated HN2-5 cells . Positive_regulation PRKCA EPHB2 18550646 1940624 Parathyroid hormone (PTH) inhibits Na+-K+-ATPase activity by serine phosphorylation of the alpha1-subunit through *dependent* phosphorylation and translocation of [protein kinase Calpha (PKCalpha)] . Positive_regulation PRKCA EPHB2 20513439 2284104 Employing PKCalpha and Erk mutants we next demonstrated that *causes* direct phosphorylation and activation of [PKCalpha] . Positive_regulation PRKCA FAS 10336417 615336 This inhibition of [PKCalpha] activity *mediated* by ligation was reversed by okadaic acid , a phosphatase inhibitor , suggesting the involvement of a member of the protein phosphatase 2A subfamily in this component of Fas signaling . Positive_regulation PRKCA IL1B 11478844 842093 PTH , tumor necrosis factor-alpha (TNF-alpha) , and *induced* translocation of [PKC-alpha] and -beta ( I ) to the plasma membrane in UMR-106 cells within 5 min . Positive_regulation PRKCA IL1B 16436473 1554458 Stimulation with *activated* [PKC-alpha] and -delta , which was blocked using the PLC inhibitor U-73122 . Positive_regulation PRKCA MAP2K6 9645686 514760 Insulin induction of [protein kinase C alpha] expression is independent of insulin receptor Tyr1162/1163 residues and *involves* 1 and sustained activation of nuclear p44MAPK . Positive_regulation PRKCA PECAM1 15084746 1237629 Maximal increase in protein occurred after incubation with LacCer for 60 min. LacCer *activated* [PKCalpha] and -epsilon by translocating them from cytosol to membrane . Positive_regulation PRKCA TLR7 19950169 2203988 Herein , we demonstrate that [PKC-alpha] is *induced* by several MyD88 dependent ligands and regulates cytokine expression in human and murine DC . Positive_regulation PRKCA TNF 10887171 730499 In L929 murine fibroblasts , ( 0.5- 5 nm ) *caused* potent inhibition of PKC alpha activity and induced translocation of [PKC alpha] from the cytosol to the membrane . Positive_regulation PRKCA TNF 11478844 842092 PTH , , and interleukin-1 beta (IL-1 beta) *induced* translocation of [PKC-alpha] and -beta ( I ) to the plasma membrane in UMR-106 cells within 5 min . Positive_regulation PRKCA TNF 17016558 1629954 [PKCalpha] *activation* by was responsible for NHE3 internalization , and pharmacological or genetic PKCalpha inhibition prevented NHE3 internalization , Na+ malabsorption , and diarrhea despite continued barrier dysfunction . Positive_regulation PRKCA TNF 7628389 316413 *stimulated* [PKC alpha] translocation was quantitated by Western blot . Positive_regulation PRKCA TNF 7628389 316414 *stimulated* [PKC alpha] translocation was further demonstrated by indirect immunofluorescence assay . Positive_regulation PRKCB ANGPT1 14584044 1187137 Opposing effect of on VEGF mediated disruption of endothelial cell-cell interactions *requires* activation of [PKC beta] . Positive_regulation PRKCB IL1B 11478844 842096 PTH , tumor necrosis factor-alpha (TNF-alpha) , and *induced* translocation of [PKC-alpha and -beta] ( I ) to the plasma membrane in UMR-106 cells within 5 min . Positive_regulation PRKCB IL1B 11478844 842101 The *stimulation* of [PKC-beta] ( I ) translocation by PTH , TNF-alpha or was inhibited by LY379196 . Positive_regulation PRKCB TNF 11478844 842095 PTH , , and interleukin-1 beta (IL-1 beta) *induced* translocation of [PKC-alpha and -beta] ( I ) to the plasma membrane in UMR-106 cells within 5 min . Positive_regulation PRKCB TNF 11478844 842100 The *stimulation* of [PKC-beta] ( I ) translocation by PTH , or IL-1 beta was inhibited by LY379196 . Positive_regulation PRKCD EPHB2 18628248 1954505 A translocation of [protein kinase C (PKC)delta] from the cytosol to the membrane followed by activation of extracellular signal regulated kinase ( ERK ) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated , and TPA induced MMP-9 activation and migration were *inhibited* by the pan PKC inhibitor , GF109203X , the specific PKCdelta inhibitor , rottlerin , an inhibitor ( PD98059 ) and an AP-1 inhibitor ( curcumin ) . Positive_regulation PRKCD HBEGF 12588978 1059738 Here , we identified two distinct signaling pathways required for receptor and nonreceptor tyrosine kinase activation by H2O2 involving a metalloprotease dependent generation of ( HB-EGF ) and [protein kinase C (PKC)-delta] *activation* , respectively . Positive_regulation PRKCD IL1B 11549843 856887 *induced* synthesis of [protein kinase C-delta] and protein kinase C-epsilon in EL4 thymoma cells : possible involvement of phosphatidylinositol 3-kinase . Positive_regulation PRKCD IL1B 9245485 446674 *induced* expression of [protein kinase C (PKC)-delta] and epsilon in NIH 3T3 cells . Positive_regulation PRKCD TNF 12055072 951601 In adherent neutrophils , *triggers* association of both [protein kinase C (PKC)-delta] and phosphatidylinositol (PI) 3-kinase with the p60TNFR . Positive_regulation PRKCE GPR115 15190080 1280783 *mediated* phosphorylation of the activation loop of protein kinase D : dependence on plasma membrane translocation and [protein kinase Cepsilon] . Positive_regulation PRKCE GPR132 15190080 1280772 *mediated* phosphorylation of the activation loop of protein kinase D : dependence on plasma membrane translocation and [protein kinase Cepsilon] . Positive_regulation PRKCE GPR87 15190080 1280852 *mediated* phosphorylation of the activation loop of protein kinase D : dependence on plasma membrane translocation and [protein kinase Cepsilon] . Positive_regulation PRKCE IL1B 11549843 856888 *induced* synthesis of protein kinase C-delta and [protein kinase C-epsilon] in EL4 thymoma cells : possible involvement of phosphatidylinositol 3-kinase . Positive_regulation PRKCZ CTGF 15319369 1303750 Inhibition of *induced* [protein kinase C-zeta] activity with a myristolated PKC-zeta inhibitor prevented cell migration . Positive_regulation PRKCZ IL1B 9020886 413131 *induced* [protein kinase C-zeta] activation is mimicked by exogenous phospholipase D . Positive_regulation PRKCZ TNF 18973186 2078972 Furthermore , UA suppressed the IL-1beta or induced *activation* of [protein kinase C-zeta (PKC-zeta)] . Positive_regulation PRKD1 EDN2 9295346 453172 Bombesin , vasopressin , , bradykinin , and platelet derived growth factor rapidly *activate* [protein kinase D] through a protein kinase C-dependent signal transduction pathway . Positive_regulation PRKD1 GPR115 11410587 849580 Rapid [protein kinase D] translocation in *response* to activation . Positive_regulation PRKD1 GPR132 11410587 849569 Rapid [protein kinase D] translocation in *response* to activation . Positive_regulation PRKD1 GPR87 11410587 849649 Rapid [protein kinase D] translocation in *response* to activation . Positive_regulation PRKD1 IL1B 17331478 1720032 Lipopolysaccharide induced [protein kinase D] activation *mediated* by and protein kinase C . Positive_regulation PRKD1 MAP2K6 11748587 889677 The retrovirally transfected CCK ( B ) /gastrin receptor binds 125I-CCK-8 with high affinity ( Kd = 1.1 nM ) and is functionally coupled to intracellular signaling pathways including rapid and transient increase in Ca2+ fluxes , protein kinase C-dependent [protein kinase D] *activation* , and dependent ERK1/2 activation . Positive_regulation PRKDC TNFSF10 22753480 2639466 In contrast , HSP90 inhibition by geldanamycin markedly enhances *induced* [DNA-PK] and H2AX activation . Positive_regulation PRL ABCG2 23150485 2729615 [PRL] dose-dependently *induced* expression in T-47D human breast cancer cells . Positive_regulation PRL CCND1 18403642 1893866 However , we have recently shown that [prolactin] can rapidly *induce* protein expression and subsequent proliferation in the MCF-7 human breast cancer cell line , suggesting that prolactin actions can be independent of IGFs in breast disease . Positive_regulation PRL CCND1 19169277 2043606 Finally , [PRL] *induces* expression of c-Myc and and leads to increased cell proliferation , which is specifically antagonized by ICI 182,780 or ERalpha depletion . Positive_regulation PRL CCND1 22392353 2577224 The immunoblotting assay showed that [prolactin] *induced* the expression of both p-JAK2 and in Hep-G2 cells . Positive_regulation PRL EPHB2 11994384 938916 [Prolactin] *induces* phosphorylation in epithelial and CD56 ( + ) natural killer cells of the human endometrium . Positive_regulation PRL EPHB2 16785991 1654033 Our data suggest that [PRL] synergistically augments EGF signaling in T47D breast cancer cells at least in part by lessening EGF induced EGFR downregulation and that this effect *requires* PRL induced activity and threonine phosphorylation of EGFR . Positive_regulation PRL EPHB2 17255201 1725258 [Prolactin] *induced* phosphorylation of JAK2 and , whereas IFN-gamma induced phosphorylation of JAK1 , JAK2 , and p38 MAPK . Positive_regulation PRL EPHB2 17550976 1784274 Finally , suppression of Jak1 by lentiviral delivery of Jak1 short hairpin RNA blocked [PRL] *activation* of and signal transducer and activator of transcription ( Stat ) 3 and suppressed PRL activation of Jak2 , Stat5a , Stat5b , and Akt , as well as tyrosine phosphorylation of PRLR . Positive_regulation PRL EPHB2 19022892 2047290 [PRL] also *induced* phosphorylation in vitro in the hypothalamic cell line , 4B , which expresses PRL receptors , and in primary hypothalamic neuronal cultures . Positive_regulation PRL EPHB2 19350575 2057645 [PRL] *induced* and JNK phosphorylation . Positive_regulation PRL EPHB2 21285319 2403438 The gsp oncogene disrupts *dependent* [prolactin] gene regulation in gsp inducible somatotroph cell line . Positive_regulation PRL IL1B 12697678 1081345 We have therefore examined the effects of AGRP on the HPA axis and on [prolactin (PRL)] at baseline and in *response* to stimulation by in nine ovariectomized rhesus monkeys . Positive_regulation PRL IL1B 17201586 1663172 Exogenous induces its own expression , but not that of IL-6 in the hypothalamus and *activates* HPA axis and [prolactin] release . Positive_regulation PRL IL1B 1802676 177004 The release of [PRL] from rat pituitary cells in 30 min was *increased* about 2-fold ( p less than 0.05 ) by 10 ( 5 ) U/l , 10 ( 5 ) U/l interleukin-6 or 100 micrograms/l TNF-alpha . Positive_regulation PRL IL1B 19021033 2006641 The involvement of Ca++ signaling and p42/44 MAP kinase in regulation of [PRL] *induced* and TNF-alpha production by macrophages has also been investigated . Positive_regulation PRL IL1B 8614237 337582 A possible role for nitric oxide but not for prostaglandin E2 in basal and *induced* [PRL] release in vitro . Positive_regulation PRL IL1B 8614237 337583 Now , we show experimental evidence of an involvement of NO in basal and *induced* [prolactin (PRL)] release . Positive_regulation PRL IL1B 8614237 337584 L-NG-nitro-arginine , an inhibitor of nitric oxide synthetase , and hemoglobin , a NO scavenger , impaired basal and *induced* [PRL] release , while molsidomine , a NO donor , was able to release PRL and to amplify interleukin-1-beta induced PRL release , confirming a modulatory role for nitric oxide in pituitary hormone secretion . Positive_regulation PRL IL1B 8614237 337585 On the other hand , no evidence regarding a possible role of prostaglandin E2 ( PGE2 ) in *induced* [PRL] release came out from our experiments . Positive_regulation PRL IL1B 8963751 343710 The absence of a comparable change in the progesterone release rate of males infused with IL-1 beta , and the presence of marked surges of prolactin (PRL) in the females , suggests that altered ovarian function , and that the persistence of large corpora lutea *induced* [PRL] release . Positive_regulation PRL IL1B 9623597 511014 The effect of IL-1beta on amniotic fluid [prolactin] does not appear to be mediated by PGs and may *involve* a direct effect of on decidual cells . Positive_regulation PRL NGFR 10606728 575142 Anandamide ( ANA ) *inhibits* [prolactin-] and nerve growth factor (NGF) induced proliferation of human breast cancer cells by decreasing the levels of the 100 kDa prolactin receptor (PRLr) and the high affinity trk , respectively , and by acting via CB(1)-like cannabinoid receptors . Positive_regulation PRL TMEM100 18613925 1935991 [PRL] activity is *dependent* on the activation of a , the PRL receptor (PRLR) . Positive_regulation PRL TMEM156 18613925 1936009 [PRL] activity is *dependent* on the activation of a , the PRL receptor (PRLR) . Positive_regulation PRL TMEM211 18613925 1936089 [PRL] activity is *dependent* on the activation of a , the PRL receptor (PRLR) . Positive_regulation PRL TMEM213 18613925 1936026 [PRL] activity is *dependent* on the activation of a , the PRL receptor (PRLR) . Positive_regulation PRL TNF 16254029 1508475 *activates* the human [prolactin] gene promoter via nuclear factor-kappaB signaling . Positive_regulation PRL TNF 16254029 1508476 Here we show that the important cytokine *activates* [prolactin] gene transcription in pituitary GH3 cells stably expressing luciferase under control of 5 kb of the human prolactin promoter . Positive_regulation PRL TNF 16325274 1526271 *activates* the extrapituitary [PRL] promoter in myeloid leukemic cells . Positive_regulation PRL TNF 17336385 1726617 [PRL] or GH *induced* production by murine macrophages was insensitive in the presence of competitive inhibitor of NOS , L-NMMA . Positive_regulation PRL TNF 1802676 177005 at 100 micrograms/l significantly *increased* [PRL] release within 5 min incubation and this effect continued throughout the next 30 min of incubation . Positive_regulation PRL TNF 19021033 2006640 The involvement of Ca++ signaling and p42/44 MAP kinase in regulation of [PRL] *induced* IL-1beta and production by macrophages has also been investigated . Positive_regulation PRL TNF 1903696 159068 *increases* release of arachidonate and [prolactin] from rat anterior pituitary cells . Positive_regulation PRL TNF 1903696 159069 significantly *increased* the release of both [PRL] and [ 3H ] arachidonate release in a time- and dose dependent manner . Positive_regulation PRL TNF 1903696 159070 *potentiated* the release of [ 3H ] arachidonate and [PRL] promoted by phospholipase-A2 and melittin , and markedly shifted the dose-response curve to the left . Positive_regulation PRL TNF 1903696 159072 Inhibitors of phospholipase-A2 , such as p-bromophenacyl bromide and quinacrine , had no effect on *induced* [ 3H ] arachidonate and [PRL] release . Positive_regulation PRL TNF 1903696 159074 BW755C , an inhibitor of the conversion of arachidonate to its metabolites , decreased *induced* [PRL] release , while indomethacin , a prostaglandin synthesis inhibitor , had no effect on TNF alpha induced PRL release . Positive_regulation PRL TNF 1903696 159075 These data indicate that arachidonate metabolites may be involved in the process of *induced* [PRL] release . Positive_regulation PRL TNF 2036963 159800 *stimulates* [prolactin] release from anterior pituitary cells : a possible involvement of intracellular calcium mobilization . Positive_regulation PRL TNF 2036963 159801 To define the role of calcium in *induced* [PRL] release , dispersed pituitary cells were exposed to agents that modify TNF alpha induced calcium mobilization . Positive_regulation PRL TNF 2036963 159802 Such calcium channel blockers as cobalt and verapamil decreased basal and *induced* [PRL] release . Positive_regulation PRL TNF 2036963 159803 A low calcium medium also decreased *induced* [PRL] release . Positive_regulation PRL TNF 2036963 159804 These data suggest that intracellular calcium mobilization may be involved in the process of *induced* [PRL] release . Positive_regulation PRL TNF 24997655 2952760 [Prolactin] *increases* alpha expression in peripheral CD14 monocytes of patients with rheumatoid arthritis . Positive_regulation PRL TNF 2564680 108645 The *stimulation* of [Prl] release by in the presence of somatostatin may be related to the elevation of cyclic AMP , a known stimulator of Prl release . Positive_regulation PRL TNF 7758825 307619 [Prolactin] *induced* expression of glial fibrillary acidic protein and at a wound site in the rat brain . Positive_regulation PRL TNF 7759566 307805 [Prolactin] *induced* expression of interleukin-1 alpha , , and transforming growth factor-alpha in cultured astrocytes . Positive_regulation PRLH EPHB2 11751586 898358 Both pertussis toxin ( 10 ng/ml ) , which inactivates Gi/Go proteins , and expression of a peptide derived from the carboxyl terminus of the beta-adrenergic receptor kinase I , which specifically blocks signaling mediated by the betagamma subunits of G proteins , completely blocked the PrRP induced Akt activation , suggesting that Gi/Go proteins are involved in PrRP induced Akt activation , as they are in the *activation* of by [PrRP] . Positive_regulation PRNP CAPN8 15026410 1243911 Our observations suggest that *mediated* endoproteolytic cleavage of [PrP] ( Sc ) may be an important event in prion propagation . Positive_regulation PRNP EPHB2 17387271 1791643 In addition , the upregulation of [PrP] ( C ) was *reduced* by inhibitor ( PD98059 ) . Positive_regulation PRNP TNF 16011481 1459388 *induces* the expression and recombinant promoter activities of GCLC , GCLM and [GSS] in H4IIE cells . Positive_regulation PRNP TNF 22116041 2541352 However , as it is known that Cbl deficiency damages myelin by increasing tumor necrosis factor (TNF)-a and decreasing epidermal growth factor (EGF) levels in rat spinal cord ( SC ) , and that and EGF *regulate* [PrP] ( C ) expression in vitro , we investigated whether Cbl deficiency modifies SC PrP ( C ) and PrP ( C ) -mRNA levels in Cbl-D rats . Positive_regulation PRNP TNF 8790403 380921 To clarify the *role* of in experimental [CJD] , we investigated the expression of TNF-alpha in brain tissues from CJD virus infected mice at weekly intervals after inoculation by reverse transcription coupled PCR , Northern and Western blot analyses , and immunocytochemical staining . Positive_regulation PROC F2R 8391599 224366 One of the mechanisms by which prevention is achieved *involves* a cell surface , thrombomodulin , which converts thrombin from a procoagulant into an anticoagulant due to accelerating thrombin catalyzed activation of an anticoagulant protease zymogen , protein C . [Activated protein C] then proteolytically inactivates coagulation cofactors , Factors Va and VIIIa , in concert with another anticoagulant protein S . Activated protein C is finally neutralized by protein C inhibitor . Positive_regulation PROC SERPINA5 8972021 402890 Heparin *stimulation* of the inhibition of [activated protein C] and other enzymes by human -- influence of the molecular weightof heparin and ionic strength . Positive_regulation PROCR F2R 15626732 1387918 Here , we show that APC enhanced endothelial barrier integrity in a dual-chamber system dependent on binding to [endothelial protein C receptor] , *activation* of , and activity of cellular sphingosine kinase . Positive_regulation PROCR TNF 19620400 2137540 Endothelial NF-kappaB blockade prevented LPS down-regulation of [endothelial protein C receptor (EPCR)] and thrombomodulin protein expressions , *inhibited* tissue converting enzyme activity , reduced EPCR shedding , and restored plasma protein C level . Positive_regulation PRODH CHDH 24410747 2907069 mutants *activated* [ProDH] as wild type plants . Positive_regulation PRODH MYLIP 23764530 2828423 Based on expression and functional analysis , we identified miR172 , miR396a , and miR4233 may regulate P5CS gene , and miR2673 and miR6461 may *regulate* P5CR and [ProDH] gene , respectively . Positive_regulation PRODH PPP3CA 15914462 1440308 The *activation* of by p53 and [proline oxidase] was detected by activation of the nuclear factor of activated T cells ( NFAT ) , an established indicator of activated calcineurin . Positive_regulation PRODH PPP3R1 15914462 1440309 The *activation* of by p53 and [proline oxidase] was detected by activation of the nuclear factor of activated T cells ( NFAT ) , an established indicator of activated calcineurin . Positive_regulation PRODH SEC14L2 23861960 2817424 We established that over-expression of or TAp63ß is sufficient to induce PRODH expression in p53-null cells and that [PRODH] expression *parallels* the modulation of endogenous p73 by genotoxic drugs in several cell lines . Positive_regulation PRODH TP53 11280728 798637 In the conditionally immortalized murine colonic epithelial cell line YAMC , where the p53 phenotype can be modulated by temperature , [proline oxidase] expression and ROS production could only be *induced* when the cells were phenotypically positive . Positive_regulation PRODH TP53 12514185 1063818 A proline oxidase antisense vector repressed induced *up-regulation* of [proline oxidase] , release of cytochrome c from mitochondria , and apoptosis in 786-0 renal carcinoma cells . Positive_regulation PRODH TP53 15914462 1440310 Both [proline oxidase-] and induced *activation* of NFAT were sensitive to the calcineurin inhibitors cyclosporin A and FK-506 , to scavengers of ROS , and to inhibitors of calcium mobilization . Positive_regulation PRODH TP53 19654292 2119092 [Proline oxidase (POX)] , catalyzing the first step in proline catabolism , is *induced* by and can regulate cell survival as well as mediate programmed cell death . Positive_regulation PRODH TP53 22796327 2660075 [PRODH] expression is *inducible* by , leading to increased proline oxidation , reactive oxygen species formation , and induction of apoptosis . Positive_regulation PRODH TP53 23861960 2817421 Here , we confirmed *dependent* induction of endogenous [PRODH] in response to genotoxic damage in cell lines of different histological origin . Positive_regulation PROK1 RCAN1 19801577 2202938 Overexpression of in PROKR1 Ishikawa cells using an adenovirus *leads* to a reduction in [PROK1] induced IL-11 indicating that RCAN1-4 is a negative regulator in the calcineurin mediated signalling to IL-11 . Positive_regulation PROM1 EPHB2 24188385 2890277 Co-culture with CM resulted in an increased resistance to Adriamycin and enhanced expressions of a-FP , MMP9 , ABCG2 , [CD133] , and SOX2 , as well as the *activation* of , AKT , WNT , and TGF-ß1 pathways . Positive_regulation PROM1 GPR87 23593389 2773478 In this study , we explored the *role* of in the regulation of [CD133] expression . Positive_regulation PROM1 GPR87 23593389 2773481 Conversely , silencing of expression *reduced* the levels of [CD133] expression . Positive_regulation PROM1 ID1 24572994 2924797 and NF-?B *promote* the generation of [CD133+] and BMI-1+ keratinocytes and the growth of xenograft tumors in mice . Positive_regulation PROM1 ID1 24572994 2924799 and NF-?B *regulate* the expression of [CD133] and BMI-1 in an additive or synergistic manner in OSCC , which is associated with the generation of naïve and self-renewable keratinocytes and initiate the growth of xenograft tumors in vivo . Positive_regulation PROX1 EPHB2 23391722 2748222 Expression of mutant RAF1 ( S259A ) in ECs activated and *induced* SOX18 and [PROX1] expression , leading to increased commitment of venous ECs to the lymphatic fate . Positive_regulation PRPF40A TNF 9794404 542947 *Induction* of [hIP-10] by also required NFkappaB binding sites , which were protected in vivo and bound p65 homodimeric NFkappaB in vitro . Positive_regulation PRPH2 GPR115 16938805 1609163 To study whether for asthma susceptibility ( GPRA ) *contributes* to [RDS] or BPD . Positive_regulation PRPH2 GPR132 16938805 1609152 To study whether for asthma susceptibility ( GPRA ) *contributes* to [RDS] or BPD . Positive_regulation PRPH2 GPR87 16938805 1609232 To study whether for asthma susceptibility ( GPRA ) *contributes* to [RDS] or BPD . Positive_regulation PRPH2 SYNM 9788584 541846 In the single-dose study , ( 20 mg/kg body weight ( bw ) ) *induced* both [RDS] and hepatotoxicity . Positive_regulation PRPH2 SYNM 9788584 541848 In the repeated-dose study , ( 4 mg/kg bw ) *induced* both [RDS] and hepatotoxicity , but MNU ( 10 mg/kg bw ) induced neither . Positive_regulation PRS EDN2 23469133 2750248 To examine directly the *role* of in mutant [PRs] , we used a scAAV5-Edn2 cDNA vector to restore Edn2 expression in Pde6b ( rd1/rd1 ) ; Positive_regulation PRSS1 TNF 16816895 1646006 After infection , mRNA levels *increased* rapidly to a peak on day one , and then [trypsin I] and matrix metalloproteinase (MMP)-9 , but not MMP-2 , were significantly up-regulated with a peak on day 2 in vivo . Positive_regulation PRSS21 SRC 10698670 671903 We evaluated the *role* of tyrosine kinase in control and EGME treated adult rat [testis in] vivo , as well as in vitro using cultured adult rat seminiferous tubules treated with MAA . Positive_regulation PRSS50 EPHB2 20506264 2307836 An inhibitor *suppressed* Sp1 phosphorylation and bFGF reduced [TSP50] expression at the mRNA level . Positive_regulation PRTN3 F2R 19132232 2005569 Using antibodies and siRNA to inhibit and silence PAR-1 and PAR-2 , we observed that [PR3] upregulation of TF is at least in part *mediated* by . Positive_regulation PRTN3 TNF 16575489 1671876 The spontaneous membrane expression of MPO and [PR3] on PMN could be significantly *increased* by lipopolysaccharide (LPS) and , but not by IL-8 or GRO-alpha . Positive_regulation PRTN3 TNF 9395784 468763 Membrane expressed PR-3 was detected by affinity purified and monoclonal [anti-PR-3] Ab. *induced* membrane expression of PR-3 could be blocked with the RNA synthesis inhibitor actinomycin D , the protein kinase C ( PKC ) and proteinase A ( PKA ) inhibitor staurosporine , the specific PKA inhibitor calphostin C , the c-AMP dependent PKA inhibitor KT5720 and the tyrosine kinase inhibitor genistein in a dose dependent manner . Positive_regulation PRX TNF 19540914 2116361 Moreover , addition of exogenous TNF allowed the recovery of full PRX5 expression in both MyD88 ( -/- ) and TNF ( -/- ) cells stimulated with IFN-gamma , suggesting that basal produced in an MyD88 dependent manner *contributes* to [PRX5] induction . Positive_regulation PRX TNF 20683885 2368086 *Activation* of [Prx1] by may contribute to reduced bone formation in inflammatory arthritis , menopause , and aging . Positive_regulation PSEN1 IL1B 12050157 968747 Cyclooxygenase-2 and [presenilin-1] gene expression *induced* by and amyloid beta 42 peptide is potentiated by hypoxia in primary human neural cells . Positive_regulation PSEN1 IL1B 12050157 968748 Together , and amyloid beta42 peptide [ IL-1beta+Abeta42 ] synergistically *activated* COX-2 and [PS1] gene expression preceded by increases in AP1- , STAT1alpha- , and in particular NF-kappaBp50/p65- and HIF-1alpha-DNA binding . Positive_regulation PSEN1 TNF 18667537 1967330 Here , we demonstrate that *triggers* JNK dependent serine/threonine phosphorylation of [PS1] and NCT to stimulate gamma-secretase activity . Positive_regulation PSEN2 TNF 19202555 2061404 Both AdVs and [Ad5WT] *induced* expression of inflammatory cytokines , such as interleukin-6 and , but , most importantly , they led to a marked and dose dependent increase of cortisol and other steroid hormone production and consistently modulated expression of key steroidogenic enzymes and regulators of steroidogenesis . Positive_regulation PSENEN ADRB2 17115048 1661142 Activation of *stimulates* [gamma-secretase] activity and accelerates amyloid plaque formation . Positive_regulation PSENEN IL1B 15347683 1333753 Using this reporter assay , we have demonstrated that interferon-gamma , , and tumor necrosis factor-alpha can specifically *stimulate* [gamma-secretase] activity , concomitant with increased production of Abeta and the intracellular domain of APP ( AICD ) . Positive_regulation PSENEN TNF 15347683 1333751 Using this reporter assay , we have demonstrated that interferon-gamma , interleukin-1beta , and can specifically *stimulate* [gamma-secretase] activity , concomitant with increased production of Abeta and the intracellular domain of APP ( AICD ) . Positive_regulation PSENEN TNF 18667537 1967329 Our previous results showed that can potently *stimulate* [gamma-secretase] activity through a c-Jun N-terminal kinase (JNK) dependent pathway . Positive_regulation PSG1 ARSA 18642044 1960162 In our subgroup analysis according to our classification based on anastomotic level and extent of pelvic dissection , local remnant tumor and poor grading also independently *increased* the risk of developing EPSBO in [PSG] . Positive_regulation PSG11 ARSA 18642044 1960163 In our subgroup analysis according to our classification based on anastomotic level and extent of pelvic dissection , local remnant tumor and poor grading also independently *increased* the risk of developing EPSBO in [PSG] . Positive_regulation PSG2 ARSA 18642044 1960164 In our subgroup analysis according to our classification based on anastomotic level and extent of pelvic dissection , local remnant tumor and poor grading also independently *increased* the risk of developing EPSBO in [PSG] . Positive_regulation PSG3 ARSA 18642044 1960165 In our subgroup analysis according to our classification based on anastomotic level and extent of pelvic dissection , local remnant tumor and poor grading also independently *increased* the risk of developing EPSBO in [PSG] . Positive_regulation PSG4 ARSA 18642044 1960166 In our subgroup analysis according to our classification based on anastomotic level and extent of pelvic dissection , local remnant tumor and poor grading also independently *increased* the risk of developing EPSBO in [PSG] . Positive_regulation PSG5 ARSA 18642044 1960167 In our subgroup analysis according to our classification based on anastomotic level and extent of pelvic dissection , local remnant tumor and poor grading also independently *increased* the risk of developing EPSBO in [PSG] . Positive_regulation PSG6 ARSA 18642044 1960168 In our subgroup analysis according to our classification based on anastomotic level and extent of pelvic dissection , local remnant tumor and poor grading also independently *increased* the risk of developing EPSBO in [PSG] . Positive_regulation PSG7 ARSA 18642044 1960169 In our subgroup analysis according to our classification based on anastomotic level and extent of pelvic dissection , local remnant tumor and poor grading also independently *increased* the risk of developing EPSBO in [PSG] . Positive_regulation PSG8 ARSA 18642044 1960170 In our subgroup analysis according to our classification based on anastomotic level and extent of pelvic dissection , local remnant tumor and poor grading also independently *increased* the risk of developing EPSBO in [PSG] . Positive_regulation PSG9 ARSA 18642044 1960171 In our subgroup analysis according to our classification based on anastomotic level and extent of pelvic dissection , local remnant tumor and poor grading also independently *increased* the risk of developing EPSBO in [PSG] . Positive_regulation PSIP1 NT5E 7759602 307830 Present results suggest that NGF , NT-3 and may *act* in [PIC] and indirectly in lymphocytes , whereas BDNF and NT-4/5 could control macrophages . Positive_regulation PSMA1 TNF 20100602 2213006 *stimulated* gene-6 protein ( TSG-6 ) [/heavy chain 2 (HC2)] cleaves this unique cross-link and transfers the HCs to hyaluronan and other glycosaminoglycans via a covalent HC*TSG-6 intermediate . Positive_regulation PSMA2 TNF 16873769 1672475 Bikunin and [HC3] ( i.e. , pre-alpha-inhibitor ) were also *induced* by in primary cultures . Positive_regulation PSMB8 TNF 8550087 339916 After 48 hr of exposure to HLA class I-modulating cytokines , [Lmp7] mRNA levels in JEG-3 cells were markedly *increased* by two interferons ( IFN-beta , IFN-gamma ) and whereas at the same time point , Jar cell Lmp7 mRNA was modestly enhanced by IFN-gamma . Positive_regulation PSMB9 IL1B 12903836 1119080 In conclusion our study shows that *increases* the transcription of the proteasome subunit [LMP2] , and that the proteasome is involved in IL-1beta induced suppression of islet function . Positive_regulation PSMB9 TNF 15240699 1270376 In murine bone marrow derived macrophages , LPS and *induced* Tap1 and up-regulated [Lmp2] , which is constitutively expressed at low levels . Positive_regulation PSMB9 TNF 15240699 1270380 In macrophages from STAT-1 knockout mice , neither LPS nor *induced* the expression of Tap1 or [Lmp2] . Positive_regulation PSMB9 TNF 15240699 1270382 These results show that LPS and *regulate* the induction of Tap1 and [Lmp2] through STAT1 , but use distinct areas of the promoter . Positive_regulation PSMB9 TNF 7699330 297462 An adjacent GC box was required for basal expression of both genes as well as augmenting the *induction* of the distal [LMP2] gene . Positive_regulation PSMC2 TNF 22921402 2678260 *enhanced* the interaction of S5b/PSMD5 with [S7/PSMC2] in nonproteasome complexes , and interference of this interaction rescued TNF-a induced proteasome inhibition . Positive_regulation PSMD4 RNASE1 12598767 1062140 In addition , an RNase inhibitor (RI) was used to determine whether the anti-viral activity of [ASF] was *due* to activity . Positive_regulation PSMD4 RNASE7 12598767 1062148 In addition , an RNase inhibitor (RI) was used to determine whether the anti-viral activity of [ASF] was *due* to activity . Positive_regulation PSMD5 TNF 22921402 2678258 *increased* [S5b] ( HGNC symbol PSMD5 ; hereafter S5b/PSMD5 ) expression via NF?B , and the surplus S5b/PSMD5 directly inhibited 26S proteasome assembly and activity . Positive_regulation PSMD5 TNF 22921402 2678261 *enhanced* the interaction of [S5b/PSMD5] with S7/PSMC2 in nonproteasome complexes , and interference of this interaction rescued TNF-a induced proteasome inhibition . Positive_regulation PTAFR TNF 9000543 410122 ( 100-400 U/mL ) significantly *increased* [PAFR] mRNA expression in human monocytes . Positive_regulation PTAFR TNF 9000543 410138 These observations provide new evidence for TNF-alpha and PAF interactions in human monocytes during inflammatory processes through *up-regulation* of [PAFR] expression by . Positive_regulation PTBP1 CCL17 12909129 1121891 Endogenous CCL17 and B7-DC mRNAs were increased similarly in IL-4 cultured [DCs] but only was *induced* by LPS . Positive_regulation PTBP1 CD14 9680340 521002 Cultures enriched in *dependent* [DCs] were more potent stimulators of a mixed leukocyte reaction , compared with control GTS cultures containing both types of DCs . Positive_regulation PTBP1 CD14 9680340 521010 When exposed to the appropriate cytokine combinations , these cells yielded granulocytes , monocytes , and *dependent* [DCs] . Positive_regulation PTBP1 CD14 9680340 521014 Although TNF is required to ensure the institution of DC hematopoiesis from CD34 ( + ) progenitor cells , its activity on a later progenitor appears to limit the development of *dependent* [DCs] . Positive_regulation PTBP1 EDN2 15528350 1332544 Additionally , and hPR also *induced* phenotypic and functional maturation [DCs] . Positive_regulation PTBP1 EDN2 18195069 1857033 Here , we report that can *activate* myeloid [DCs] by triggering the Toll-like receptor (TLR)2-myeloid differentiation factor 88 signaling pathway , thus establishing EDN as an endogenous ligand of TLR2 . Positive_regulation PTBP1 EPHB2 20967853 2369599 Selective activation *induced* mouse and human [DCs] to secrete bioactive transforming growth factor ß , a process required for suppression of T cell responses and differentiation of antigen-specific Treg cells . Positive_regulation PTBP1 FAS 10756053 682848 In this study , human monocyte derived [DCs] were used to demonstrate that DC apoptosis in MV-infected DC-T-cell cocultures is *mediated* , whereas apoptotic T cells could not be rescued by blocking the Fas pathway . Positive_regulation PTBP1 FAS 10756053 682858 A model is proposed to explain how both a specific immune response and immunosuppression can simultaneously occur after MV infection through mediated apoptosis and CD40 *activation* of [DCs] . Positive_regulation PTBP1 FAS 11104808 756544 *activated* [DCs] upregulate the expression of the major histocompatibility complex class II , B7 , and DC-lysosome associated membrane protein ( DC-LAMP ) molecules and secrete proinflammatory cytokines , in particular interleukin (IL)-1beta and tumor necrosis factor alpha . Positive_regulation PTBP1 FAS 23943615 2845261 Here , we show that CD11b ( hi ) Ia ( low ) regulatory [DCs] expressed high level of Fas , and endothelial stromal cell derived TGF-ß could *induce* high expression of on regulatory DCs via ERK activation . Positive_regulation PTBP1 FAS 23943615 2845270 ligation could *promote* regulatory [DCs] to inhibit CD4 ( + ) T cell proliferation more significantly . Positive_regulation PTBP1 FAS 23943615 2845278 Furthermore , ligation preferentially *induced* regulatory [DCs] to produce IL-10 and IP-10 via ERK mediated inactivation of GSK-3 and subsequent up-regulation of ß-catenin . Positive_regulation PTBP1 IL1B 14666382 1242543 Monocyte derived [DCs] were generated in a culture of monocyte with interleukin 4 (IL-4) and granulocyte-macrophage colony stimulating factor , and the maturation of DCs was *induced* by either lipopolysaccharide (LPS) or a proinflammatory cytokine cocktail : tumor-necrosis factor alpha , prostaglandin E2 , IL-6 , and . Positive_regulation PTBP1 IL1B 15560757 1341039 *Stimulation* of day 8 [DCs] from AD patients with TNF-alpha and enhanced the expression of CD83 and CD86 and restored the production of IL-16 . Positive_regulation PTBP1 IL1B 20386470 2245280 LPS stimulation of [DCs] *induced* IL-10 , IL-12p70 , TNFalpha and secretion , and taxol pretreatment modified this response by down regulating IL-1beta secretion whereas colchicine induced a proinflammatory cytokine profile with reduced IL-10 and increased IL-12p70 and TNFalpha secretion . Positive_regulation PTBP1 ITGB2 19234188 2040161 Taken together , one of the mechanisms of Treg mediated suppression functions across species and mediates an *dependent* interaction between Tregs and [DCs] . Positive_regulation PTBP1 ITGB2 23817428 2815794 Therefore , our results indicate that *dependent* interactions between T cells and [DCs] play a crucial role not only in supporting firm arrest during Ag recognition but also in facilitating the Ag scanning processes . Positive_regulation PTBP1 JAG1 19003206 1184961 Our results show that orally administered *induce* systemic T cell unresponsiveness through splenic [DCs] without inducing cell division of T cells , thus providing evidence that splenic DCs are involved in oral tolerance induction . Positive_regulation PTBP1 MAP2K6 24670797 2934990 Our previous research demonstrates that *activation* of [dendritic cells (DCs)] through is required for Ni-induced allergy in mice . Positive_regulation PTBP1 S1PR3 20826749 2325218 Thus , in vitro generated [DCs] *require* S1P(1) and to accomplish this , whereas skin derived DCs migrate unhindered in the absence of S1P(3) but not when S1P(1) signaling is blocked . Positive_regulation PTBP1 TCN1 24296809 2921400 Functionally , OK-432 plus IFN-? conditioned [DCs] *induce* remarkable Th1 and responses more effectively than OK-432 alone , even more than the use of a-type-1 cytokine cocktail . Positive_regulation PTBP1 TLR7 12515817 1039231 Polarized Th1 responses resulting from high antigen dose were not additionally enhanced by *stimulation* of [DCs] by ligands . Positive_regulation PTBP1 TLR7 12682240 1077647 We hypothesized that microbial ligands could *activate* [DCs] to cross-present Ag to CTLs . Positive_regulation PTBP1 TLR7 12776992 1095469 Each can *activate* [DCs] in a similar , but distinct manner . Positive_regulation PTBP1 TLR7 15585847 1345809 Thus , proinflammatory cytokines produced by *activated* , mature [DCs] are required for reversal of Treg anergy , but are not required to overcome Treg suppression . Positive_regulation PTBP1 TLR7 15597784 1346541 We demonstrate that SOCS1 and SOCS3 *play* an important regulatory role in macrophages and [dendritic cells (DCs)] by modulating signaling . Positive_regulation PTBP1 TLR7 15995707 1434818 Synergic stimulation increased production of interleukins 12 and 23 and *increased* the Delta-4/Jagged-1 ratio , leading to [DCs] with enhanced and sustained T helper type 1-polarizing capacity . Positive_regulation PTBP1 TLR7 16219795 1508118 Interleukin-12 (IL-12) is a heterodimeric cytokine produced by [dendritic cells (DCs)] in *response* to ligation . Positive_regulation PTBP1 TLR7 17041145 1649359 In conclusion , we demonstrate that the anti-microbial peptide LL-37 inhibits the *activation* of [DCs] by ligands . Positive_regulation PTBP1 TLR7 17218388 1724878 In our study we demonstrate that *stimulation* of monocyte derived [DCs] with ligands differentially affects the uptake and cross-presentation of cellular antigens . Positive_regulation PTBP1 TLR7 17237413 1689922 In this study we demonstrate that the ability of *activated* [DCs] to suppress Th2 cell development is Ag dose independent and unique to DCs that have been activated through TLRs vs by cytokines . Positive_regulation PTBP1 TLR7 17237413 1689966 We show that *activated* [DCs] inhibit early IL-4 production by CD4 T cells and thus inhibit their ability to subsequently increase GATA-3 expression and commit to the Th2 lineage . Positive_regulation PTBP1 TLR7 17238832 1664280 Further , Stat3 was phosphorylated and bound to the IL-10 promoter in *stimulated* [DCs] . Positive_regulation PTBP1 TLR7 17414322 1722536 Together , our data suggest that ligands *induce* the generation of mature [DCs] that integrate migratory and cytokine secretory capacity as well as cytotoxic T lymphocyte ( CTL ) stimulatory properties . Positive_regulation PTBP1 TLR7 17430585 1728939 ligand stimulation *induced* [DCs] capable of secreting IL-12p70 in primary cultures and after one day of coculture with CD40L expressing fibroblasts , mimicking an encounter with T cells . Positive_regulation PTBP1 TLR7 17508961 1745107 Activation of TLRs by administration of specific bacterial ligands , in particular lipopolysaccharide , can augment airway sensitization in mice , and there is evidence that this process involves *dependent* activation of [DCs] . Positive_regulation PTBP1 TLR7 17548596 1752169 Produced by [dendritic cells (DCs)] in *response* to ligands , IL-27 recently emerged as a key regulator of inflammatory responses . Positive_regulation PTBP1 TLR7 17848994 1795806 mediated *activation* of [dendritic cells (DCs)] is known to be a critical event in the initiation of cellular and humoral immune responses . Positive_regulation PTBP1 TLR7 18259609 1877410 A prerequisite for strong adaptive antiviral immunity is the robust initial activation of the innate immune system , which is frequently mediated by *activated* plasmacytoid [DCs] ( pDCs ) . Positive_regulation PTBP1 TLR7 18424745 1899984 Furthermore , T. gondii activated plasmacytoid [DCs] produce high levels of IL-12 and both plasmacytoid DC maturation and cytokine production are *dependent* on . Positive_regulation PTBP1 TLR7 19017945 1991931 In these ways , *activated* [DCs] are able to activate naive Th cells and initiate Th1 and Th17 responses , and TLR ligands thus serve as adjuvants for these types of responses . Positive_regulation PTBP1 TLR7 19164127 2048391 We also showed that the Jak/STAT signaling pathway was involved in CD40 expression and cytokine production in *stimulated* [DCs] but negatively regulated CD83 expression and cytokine secretion in DCs activated through TLR8 . Positive_regulation PTBP1 TLR7 19255934 2175740 The aim of our study was to determine whether *mediated* stimulation of monocytes and [dendritic cells (DCs)] contributes to the higher levels of CCL18 in SSc . Positive_regulation PTBP1 TLR7 19625644 2118383 We have investigated the ability of *stimulated* human Langerhans cells ( LC ) , dermal DCs (dDC) , and monocyte derived [DCs] ( moDC ) to affect naive and memory Th17 and Th1 responses . Positive_regulation PTBP1 TLR7 19625644 2118423 *stimulated* [DCs] were capable of inducing IL-17A and IFN-gamma production from memory T cells , although the mechanism used by each DC subset differed . Positive_regulation PTBP1 TLR7 19836139 2196417 Additionally , saliva treated [DCs] also presented a similar pattern of cytokine modulation in *response* to other ligands . Positive_regulation PTBP1 TLR7 19854106 2203273 Here , we demonstrate that several ligands , particularly LPS and a synthetic lipoprotein , *activate* human [DCs] to direct increased human Th17 differentiation . Positive_regulation PTBP1 TLR7 20200270 2229549 In *response* to signaling , conventional [DCs] can also produce IFN-beta but not IFN-alpha in a type I IFN independent manner . Positive_regulation PTBP1 TLR7 20361966 2282027 TcES with chemically altered glycans failed to modulate mediated *activation* of [DCs] and their Th1-inhibitng ability , which was STAT6 independent . Positive_regulation PTBP1 TLR7 20451253 2275273 However , down-modulation of chemokine production was observed in simultaneously *stimulated* [DCs] . Positive_regulation PTBP1 TLR7 20498209 2289111 Systemic sclerosis ( SSc ) is an autoimmune disease and accumulating evidence suggests a role for *mediated* activation of [dendritic cells (DCs)] . Positive_regulation PTBP1 TLR7 20498209 2289171 The altered mediated *activation* of [DCs] may be responsible for Th2 skewed T-cell activation in SSc that may be orchestrated by fibrogenic T-cell cytokines , such as IL-4 and IL-13 . Positive_regulation PTBP1 TLR7 20547386 2295883 Collectively , these results demonstrate that dsRNA activated DCs induce more highly polarized human Th1 responses than the other ligand *activated* [DCs] tested here . Positive_regulation PTBP1 TLR7 21469103 2422742 In the presence of *activated* splenic [DCs] , Foxp3 was transiently induced in naïve T cells by TGF-ß but was downregulated at later time points . Positive_regulation PTBP1 TLR7 21493800 2444176 These results suggest that TLR4 and signals together *induce* [DCs] with fully mature and less mature phenotypes that are both required to more efficiently prime CD8+ T cells with qualities associated with memory T cells . Positive_regulation PTBP1 TLR7 21690322 2455630 DCs are important primary targets of TSLP , and we unexpectedly demonstrated that [DCs] also produce TSLP in *response* to stimulation and that this is augmented by IL-4 . Positive_regulation PTBP1 TLR7 21711348 2460700 In this study , we attempted to determine whether AIMP1 is capable of regulating the expression of TLRs , and also capable of affecting the *mediated* activation of [DCs] . Positive_regulation PTBP1 TLR7 22482518 2589175 Our data show that soluble products of T. suis , S. mansoni and T. spiralis suppress TNF-a and IL-12 secretion by *activated* human [DCs] , and that T. suis and S. mansoni , but not T. spiralis , strongly enhance expression of OX40L . Positive_regulation PTBP1 TLR7 22534476 2618648 *activated* conventional [DCs] promote ?-secretase mediated conditioning of plasmacytoid DCs . Positive_regulation PTBP1 TLR7 22753939 2627342 We demonstrate that concurrent Notch and stimulation results in a unique cytokine profile in mouse bone-marrow *derived* [DCs] characterized by enhanced IL-10 and IL-2 , and reduced IL-12 expression compared with TLR ligation alone . Positive_regulation PTBP1 TLR7 22777000 2719488 Synergistic *activated* [DCs] were also able to induce lymphocytes possessing the specific cytotoxicity against MC38-CEA cells in vitro . Positive_regulation PTBP1 TLR7 22916243 2657697 Expression of Plexin-B2 and Plexin-D1 is modulated upon *activation* of [DCs] by ligands , TNFa , and anti-CD40 , again in a reciprocal fashion . Positive_regulation PTBP1 TLR7 22962607 2668010 We could show that *induced* [DCs] are characterized by a predominance of costimulatory over coinhibitory molecules and by high secretion of IL-12p70 , but not IL-10 . Positive_regulation PTBP1 TLR7 22962607 2668050 By means of IL-12p70 secretion , only *induced* [DCs] activated NK cells . Positive_regulation PTBP1 TLR7 23257360 2724788 Given the expansion of CD11c+ DCs during the progression of atherosclerosis and the key role of T cell activation in atherogenesis , we sought to understand the *role* of signaling in CD11c+ [DCs] in atherosclerosis . Positive_regulation PTBP1 TLR7 23291967 2769327 IRF5 deficiency reduces IFN-a , IFN-ß and IL-6 production by Toll-like receptor 9 (TLR9)- and *stimulated* [DCs] and reduces TLR7- and TLR9 induced IL-6 production by B cells to a similar extent in the two lines . Positive_regulation PTBP1 TLR7 23791643 2807857 The intracellular signaling molecule TRAF6 is critical for mediated *activation* of [dendritic cells (DCs)] . Positive_regulation PTBP1 TNF 10201904 605662 Dual *stimulations* of monocyte derived [DCs] with and IL-10 selectively antagonized their respective effects on these DC properties . Positive_regulation PTBP1 TNF 11035052 740881 Contrasting with our previous report using cultured splenic DCs , freshly isolated splenic [DCs] killed YAC-1 cells using a Ca ( 2+ ) -independent mechanism , but this function did not appear *mediated* by Fas ligand , TNF related apoptosis inducing ligand , or . Positive_regulation PTBP1 TNF 11369638 817515 Here it is reported that prostaglandin E ( 2 ) ( PGE ( 2 ) ) , an inflammatory mediator with a previously known Th2 driving function , dose-dependently enhances the IL-12p40 mRNA expression and the secretion of IL-12p40 protein in human *stimulated* immature [dendritic cells (DCs)] . Positive_regulation PTBP1 TNF 11369638 817519 In addition to the selective induction of IL-12p40 in *stimulated* [DCs] , PGE ( 2 ) inhibited the production of IL-12p70 and IL-12p40 in DCs stimulated with LPS or CD40 ligand . Positive_regulation PTBP1 TNF 11781361 900318 In conclusion , this study describes that stimulation by *results* in incompletely matured [DCs] ( semi-mature DCs ) which induce peptide-specific IL-10 producing T cells in vivo and prevent EAE . Positive_regulation PTBP1 TNF 11849317 912769 In this assay we analysed the migratory ability of interleukin-4 (IL-4)/granulocyte macrophage-colony stimulating factor ( GM-CSF ) -derived immature DCs as well as mature [DCs] , *induced* by and modified vaccinia virus Ankara ( MVA ) . Positive_regulation PTBP1 TNF 12471118 1023044 Further characterization of MTSA differentiated DCs showed that they were immature in nature , as *stimulation* of these [DCs] with , anti-CD40 , or LPS further up-regulated the surface levels of various molecules together with an increase in their T cell stimulatory capacity . Positive_regulation PTBP1 TNF 12662282 1074305 [DCs] cultured in serum-free media from adherent or CD14+ apheresis MNCs ( n = 36 ) in the *presence* of GM-CSF + IL4 +/- were frozen and stored at -80 degrees C in 6-percent HES , 5-percent DMSO , and 4-percent HSA . Positive_regulation PTBP1 TNF 12832450 1105605 Phenotypic activation of [DCs] exposed to PrP ( 106-126 ) is partly a *result* of an autocrine response and results in an increased ability of these cells to induce lymphocyte proliferation . Positive_regulation PTBP1 TNF 12928370 1131967 , but not IL-1 , *induce* monocytes to become [DCs] despite the presence of fibroblasts . Positive_regulation PTBP1 TNF 12928370 1131972 *induced* [DCs] contain Langerin positive cells and are able to induce allogenic T cell proliferation . Positive_regulation PTBP1 TNF 14611814 1162837 Increasing enhanced the survival of culturing stem cells and *resulted* in a parallel increase in day 14 [DCs] . Positive_regulation PTBP1 TNF 14632659 1170661 SB203580 , a specific inhibitor of p38 MAPK , partially or markedly inhibited the phenotypic changes of [DCs] *induced* by or DNCB , respectively . Positive_regulation PTBP1 TNF 15193925 1259645 Individual expression of human SLAM , interferon alpha/beta receptor , , and lymphotoxin-alpha or beta from T cells was not *required* for MV-infected [DCs] to inhibit the proliferation of T cells . Positive_regulation PTBP1 TNF 15560757 1341038 *Stimulation* of day 8 [DCs] from AD patients with and IL-1beta enhanced the expression of CD83 and CD86 and restored the production of IL-16 . Positive_regulation PTBP1 TNF 15726369 1389628 Mature [Mo-DCs] ( mMo-DCs ) were *induced* from imMo-DCs with and prostaglandin E ( 2 ) . Positive_regulation PTBP1 TNF 15730393 1377478 However , *stimulated* [DCs] produce low levels of IL-12 . Positive_regulation PTBP1 TNF 15766407 1383669 [DCs] *induced* by GM-CSF+IL-4 and had DC-classical phenotypic characteristics . Positive_regulation PTBP1 TNF 16388755 1505805 [DCs] in peripheral blood mononuclear cells ( PBMCs ) from gastric cancer patients were *induced* with rhGM-CSF , rhIL-4 and . Positive_regulation PTBP1 TNF 17113033 1667782 Our data showed that transcript and protein of DDR2 were expressed constitutively in immature DCs and upregulated in *stimulated* mature [DCs] . Positive_regulation PTBP1 TNF 18056756 1943910 *stimulated* [DCs] have been shown to restore tolerance in experimental autoimmune encephalomyelitis and collagen induced arthritis ( CIA ) . Positive_regulation PTBP1 TNF 18180802 1883500 The results show that the T-HSP70 is capable of maturing human [DCs] *inducing* an increase in the expression level of the CD83 , CD86 and human leukocyte antigen-DR surface markers , as well as in the secretion of interleukin (IL)-12 , and IL-6 cytokines . Positive_regulation PTBP1 TNF 18318992 1881057 Differential expression patterns of PD-L1 and PD-L2 were found when [DCs] were *triggered* by CD40 ligand and . Positive_regulation PTBP1 TNF 18318992 1881063 PD-L1 expression was repressed and PD-L2 expression remained unchanged in mature CD40 ligated DCs , whereas *stimulated* [DCs] kept high expression of PD-L1 and significantly enhanced PD-L2 expression on DCs . Positive_regulation PTBP1 TNF 19058839 2023989 Using real-time RT-PCR and HPLC , the expression and activity of IDO were assessed in *induced* mature [DCs] from HDM-sensitive and nonatopic patients with asthma in response to Der p 1 exposure ex vivo . Positive_regulation PTBP1 TNF 19710690 2186344 In accordance with the elevated MMP-9 release , on co-culture with TNFalpha/IL-1beta stimulated fibroblasts , DCs migrated significantly more effectively through matrigel matrices than did *stimulated* [DCs] . Positive_regulation PTBP1 TNF 20237317 2265982 Sustained secretion is *essential* for robust T-cell activation by [DCs] . Positive_regulation PTBP1 TNF 20386470 2245275 LPS stimulation of [DCs] *induced* IL-10 , IL-12p70 , and IL-1beta secretion , and taxol pretreatment modified this response by down regulating IL-1beta secretion whereas colchicine induced a proinflammatory cytokine profile with reduced IL-10 and increased IL-12p70 and TNFalpha secretion . Positive_regulation PTBP1 TNF 20943074 2332974 [DCs] from healthy human peripheral monocytes ( PBMCs ) were *induced* in vitro with rhGM-CSF , rhIL-4 , Flt3-L and . Positive_regulation PTBP1 TNF 22257833 2564430 We also noted elevated levels of inflammatory mediators , of which *activates* [DCs] and endothelial cells-was the highest . Positive_regulation PTBP1 TNF 22486596 2606885 Here , we show that parasite GPIs efficiently activate [DCs] through TLR2 mediated signalling mechanism and *induce* the production of and IL-12 . Positive_regulation PTBP1 TNF 7561684 324230 These [CFU-DCs] can be expanded for several weeks by in vitro culture with c-kit-ligand , and their differentiation *requires* exogenous in addition to GM-CSF . Positive_regulation PTBP1 TNF 8542932 338760 We show that the *dependent* ex vivo generation of [DCs] from mobilized CD34+ cells is 2.5-fold enhanced by flk-2/flt-3 ligand or c-kit ligand ( stem cell factor ) and five-fold enhanced by a combination of these growth factors . Positive_regulation PTBP1 TNFSF10 11035052 740882 Contrasting with our previous report using cultured splenic DCs , freshly isolated splenic [DCs] killed YAC-1 cells using a Ca ( 2+ ) -independent mechanism , but this function did not appear *mediated* by Fas ligand , , or TNF-alpha . Positive_regulation PTBP2 CCL17 12909129 1121887 Endogenous CCL17 and B7-DC mRNAs were increased similarly in IL-4 cultured [DCs] but only was *induced* by LPS . Positive_regulation PTBP2 CD14 9680340 520999 Cultures enriched in *dependent* [DCs] were more potent stimulators of a mixed leukocyte reaction , compared with control GTS cultures containing both types of DCs . Positive_regulation PTBP2 CD14 9680340 521007 When exposed to the appropriate cytokine combinations , these cells yielded granulocytes , monocytes , and *dependent* [DCs] . Positive_regulation PTBP2 CD14 9680340 521011 Although TNF is required to ensure the institution of DC hematopoiesis from CD34 ( + ) progenitor cells , its activity on a later progenitor appears to limit the development of *dependent* [DCs] . Positive_regulation PTBP2 EDN2 15528350 1332523 Additionally , and hPR also *induced* phenotypic and functional maturation [DCs] . Positive_regulation PTBP2 EDN2 18195069 1857024 Here , we report that can *activate* myeloid [DCs] by triggering the Toll-like receptor (TLR)2-myeloid differentiation factor 88 signaling pathway , thus establishing EDN as an endogenous ligand of TLR2 . Positive_regulation PTBP2 EPHB2 20967853 2369592 Selective activation *induced* mouse and human [DCs] to secrete bioactive transforming growth factor ß , a process required for suppression of T cell responses and differentiation of antigen-specific Treg cells . Positive_regulation PTBP2 FAS 10756053 682845 In this study , human monocyte derived [DCs] were used to demonstrate that DC apoptosis in MV-infected DC-T-cell cocultures is *mediated* , whereas apoptotic T cells could not be rescued by blocking the Fas pathway . Positive_regulation PTBP2 FAS 10756053 682855 A model is proposed to explain how both a specific immune response and immunosuppression can simultaneously occur after MV infection through mediated apoptosis and CD40 *activation* of [DCs] . Positive_regulation PTBP2 FAS 11104808 756541 *activated* [DCs] upregulate the expression of the major histocompatibility complex class II , B7 , and DC-lysosome associated membrane protein ( DC-LAMP ) molecules and secrete proinflammatory cytokines , in particular interleukin (IL)-1beta and tumor necrosis factor alpha . Positive_regulation PTBP2 FAS 23943615 2845258 Here , we show that CD11b ( hi ) Ia ( low ) regulatory [DCs] expressed high level of Fas , and endothelial stromal cell derived TGF-ß could *induce* high expression of on regulatory DCs via ERK activation . Positive_regulation PTBP2 FAS 23943615 2845267 ligation could *promote* regulatory [DCs] to inhibit CD4 ( + ) T cell proliferation more significantly . Positive_regulation PTBP2 FAS 23943615 2845275 Furthermore , ligation preferentially *induced* regulatory [DCs] to produce IL-10 and IP-10 via ERK mediated inactivation of GSK-3 and subsequent up-regulation of ß-catenin . Positive_regulation PTBP2 IL1B 14666382 1242529 Monocyte derived [DCs] were generated in a culture of monocyte with interleukin 4 (IL-4) and granulocyte-macrophage colony stimulating factor , and the maturation of DCs was *induced* by either lipopolysaccharide (LPS) or a proinflammatory cytokine cocktail : tumor-necrosis factor alpha , prostaglandin E2 , IL-6 , and . Positive_regulation PTBP2 IL1B 15560757 1341027 *Stimulation* of day 8 [DCs] from AD patients with TNF-alpha and enhanced the expression of CD83 and CD86 and restored the production of IL-16 . Positive_regulation PTBP2 IL1B 20386470 2245242 LPS stimulation of [DCs] *induced* IL-10 , IL-12p70 , TNFalpha and secretion , and taxol pretreatment modified this response by down regulating IL-1beta secretion whereas colchicine induced a proinflammatory cytokine profile with reduced IL-10 and increased IL-12p70 and TNFalpha secretion . Positive_regulation PTBP2 ITGB2 19234188 2040155 Taken together , one of the mechanisms of Treg mediated suppression functions across species and mediates an *dependent* interaction between Tregs and [DCs] . Positive_regulation PTBP2 ITGB2 23817428 2815788 Therefore , our results indicate that *dependent* interactions between T cells and [DCs] play a crucial role not only in supporting firm arrest during Ag recognition but also in facilitating the Ag scanning processes . Positive_regulation PTBP2 JAG1 19003206 1184958 Our results show that orally administered *induce* systemic T cell unresponsiveness through splenic [DCs] without inducing cell division of T cells , thus providing evidence that splenic DCs are involved in oral tolerance induction . Positive_regulation PTBP2 MAP2K6 24670797 2934945 Our previous research demonstrates that *activation* of [dendritic cells (DCs)] through is required for Ni-induced allergy in mice . Positive_regulation PTBP2 S1PR3 20826749 2325204 Thus , in vitro generated [DCs] *require* S1P(1) and to accomplish this , whereas skin derived DCs migrate unhindered in the absence of S1P(3) but not when S1P(1) signaling is blocked . Positive_regulation PTBP2 TCN1 24296809 2921394 Functionally , OK-432 plus IFN-? conditioned [DCs] *induce* remarkable Th1 and responses more effectively than OK-432 alone , even more than the use of a-type-1 cytokine cocktail . Positive_regulation PTBP2 TLR7 12515817 1039201 Polarized Th1 responses resulting from high antigen dose were not additionally enhanced by *stimulation* of [DCs] by ligands . Positive_regulation PTBP2 TLR7 12682240 1077617 We hypothesized that microbial ligands could *activate* [DCs] to cross-present Ag to CTLs . Positive_regulation PTBP2 TLR7 12776992 1095439 Each can *activate* [DCs] in a similar , but distinct manner . Positive_regulation PTBP2 TLR7 15585847 1345779 Thus , proinflammatory cytokines produced by *activated* , mature [DCs] are required for reversal of Treg anergy , but are not required to overcome Treg suppression . Positive_regulation PTBP2 TLR7 15597784 1346511 We demonstrate that SOCS1 and SOCS3 *play* an important regulatory role in macrophages and [dendritic cells (DCs)] by modulating signaling . Positive_regulation PTBP2 TLR7 15995707 1434788 Synergic stimulation increased production of interleukins 12 and 23 and *increased* the Delta-4/Jagged-1 ratio , leading to [DCs] with enhanced and sustained T helper type 1-polarizing capacity . Positive_regulation PTBP2 TLR7 16219795 1508088 Interleukin-12 (IL-12) is a heterodimeric cytokine produced by [dendritic cells (DCs)] in *response* to ligation . Positive_regulation PTBP2 TLR7 17041145 1649329 In conclusion , we demonstrate that the anti-microbial peptide LL-37 inhibits the *activation* of [DCs] by ligands . Positive_regulation PTBP2 TLR7 17218388 1724848 In our study we demonstrate that *stimulation* of monocyte derived [DCs] with ligands differentially affects the uptake and cross-presentation of cellular antigens . Positive_regulation PTBP2 TLR7 17237413 1689892 In this study we demonstrate that the ability of *activated* [DCs] to suppress Th2 cell development is Ag dose independent and unique to DCs that have been activated through TLRs vs by cytokines . Positive_regulation PTBP2 TLR7 17237413 1689936 We show that *activated* [DCs] inhibit early IL-4 production by CD4 T cells and thus inhibit their ability to subsequently increase GATA-3 expression and commit to the Th2 lineage . Positive_regulation PTBP2 TLR7 17238832 1664250 Further , Stat3 was phosphorylated and bound to the IL-10 promoter in *stimulated* [DCs] . Positive_regulation PTBP2 TLR7 17414322 1722506 Together , our data suggest that ligands *induce* the generation of mature [DCs] that integrate migratory and cytokine secretory capacity as well as cytotoxic T lymphocyte ( CTL ) stimulatory properties . Positive_regulation PTBP2 TLR7 17430585 1728909 ligand stimulation *induced* [DCs] capable of secreting IL-12p70 in primary cultures and after one day of coculture with CD40L expressing fibroblasts , mimicking an encounter with T cells . Positive_regulation PTBP2 TLR7 17508961 1745077 Activation of TLRs by administration of specific bacterial ligands , in particular lipopolysaccharide , can augment airway sensitization in mice , and there is evidence that this process involves *dependent* activation of [DCs] . Positive_regulation PTBP2 TLR7 17548596 1752139 Produced by [dendritic cells (DCs)] in *response* to ligands , IL-27 recently emerged as a key regulator of inflammatory responses . Positive_regulation PTBP2 TLR7 17848994 1795776 mediated *activation* of [dendritic cells (DCs)] is known to be a critical event in the initiation of cellular and humoral immune responses . Positive_regulation PTBP2 TLR7 18259609 1877380 A prerequisite for strong adaptive antiviral immunity is the robust initial activation of the innate immune system , which is frequently mediated by *activated* plasmacytoid [DCs] ( pDCs ) . Positive_regulation PTBP2 TLR7 18424745 1899954 Furthermore , T. gondii activated plasmacytoid [DCs] produce high levels of IL-12 and both plasmacytoid DC maturation and cytokine production are *dependent* on . Positive_regulation PTBP2 TLR7 19017945 1991901 In these ways , *activated* [DCs] are able to activate naive Th cells and initiate Th1 and Th17 responses , and TLR ligands thus serve as adjuvants for these types of responses . Positive_regulation PTBP2 TLR7 19164127 2048388 We also showed that the Jak/STAT signaling pathway was involved in CD40 expression and cytokine production in *stimulated* [DCs] but negatively regulated CD83 expression and cytokine secretion in DCs activated through TLR8 . Positive_regulation PTBP2 TLR7 19255934 2175710 The aim of our study was to determine whether *mediated* stimulation of monocytes and [dendritic cells (DCs)] contributes to the higher levels of CCL18 in SSc . Positive_regulation PTBP2 TLR7 19625644 2118343 We have investigated the ability of *stimulated* human Langerhans cells ( LC ) , dermal DCs (dDC) , and monocyte derived [DCs] ( moDC ) to affect naive and memory Th17 and Th1 responses . Positive_regulation PTBP2 TLR7 19625644 2118393 *stimulated* [DCs] were capable of inducing IL-17A and IFN-gamma production from memory T cells , although the mechanism used by each DC subset differed . Positive_regulation PTBP2 TLR7 19836139 2196387 Additionally , saliva treated [DCs] also presented a similar pattern of cytokine modulation in *response* to other ligands . Positive_regulation PTBP2 TLR7 19854106 2203243 Here , we demonstrate that several ligands , particularly LPS and a synthetic lipoprotein , *activate* human [DCs] to direct increased human Th17 differentiation . Positive_regulation PTBP2 TLR7 20200270 2229545 In *response* to signaling , conventional [DCs] can also produce IFN-beta but not IFN-alpha in a type I IFN independent manner . Positive_regulation PTBP2 TLR7 20361966 2281997 TcES with chemically altered glycans failed to modulate *mediated* activation of [DCs] and their Th1-inhibitng ability , which was STAT6 independent . Positive_regulation PTBP2 TLR7 20451253 2275243 However , down-modulation of chemokine production was observed in simultaneously *stimulated* [DCs] . Positive_regulation PTBP2 TLR7 20498209 2289081 Systemic sclerosis ( SSc ) is an autoimmune disease and accumulating evidence suggests a role for mediated *activation* of [dendritic cells (DCs)] . Positive_regulation PTBP2 TLR7 20498209 2289141 The altered mediated *activation* of [DCs] may be responsible for Th2 skewed T-cell activation in SSc that may be orchestrated by fibrogenic T-cell cytokines , such as IL-4 and IL-13 . Positive_regulation PTBP2 TLR7 20547386 2295853 Collectively , these results demonstrate that dsRNA activated DCs induce more highly polarized human Th1 responses than the other ligand *activated* [DCs] tested here . Positive_regulation PTBP2 TLR7 21469103 2422735 In the presence of *activated* splenic [DCs] , Foxp3 was transiently induced in naïve T cells by TGF-ß but was downregulated at later time points . Positive_regulation PTBP2 TLR7 21493800 2444173 These results suggest that TLR4 and signals together *induce* [DCs] with fully mature and less mature phenotypes that are both required to more efficiently prime CD8+ T cells with qualities associated with memory T cells . Positive_regulation PTBP2 TLR7 21690322 2455589 DCs are important primary targets of TSLP , and we unexpectedly demonstrated that [DCs] also produce TSLP in *response* to stimulation and that this is augmented by IL-4 . Positive_regulation PTBP2 TLR7 21711348 2460670 In this study , we attempted to determine whether AIMP1 is capable of regulating the expression of TLRs , and also capable of affecting the mediated *activation* of [DCs] . Positive_regulation PTBP2 TLR7 22482518 2589145 Our data show that soluble products of T. suis , S. mansoni and T. spiralis suppress TNF-a and IL-12 secretion by *activated* human [DCs] , and that T. suis and S. mansoni , but not T. spiralis , strongly enhance expression of OX40L . Positive_regulation PTBP2 TLR7 22534476 2618618 *activated* conventional [DCs] promote ?-secretase mediated conditioning of plasmacytoid DCs . Positive_regulation PTBP2 TLR7 22753939 2627300 We demonstrate that concurrent Notch and stimulation results in a unique cytokine profile in mouse bone-marrow *derived* [DCs] characterized by enhanced IL-10 and IL-2 , and reduced IL-12 expression compared with TLR ligation alone . Positive_regulation PTBP2 TLR7 22777000 2719458 Synergistic *activated* [DCs] were also able to induce lymphocytes possessing the specific cytotoxicity against MC38-CEA cells in vitro . Positive_regulation PTBP2 TLR7 22916243 2657664 Expression of Plexin-B2 and Plexin-D1 is modulated upon *activation* of [DCs] by ligands , TNFa , and anti-CD40 , again in a reciprocal fashion . Positive_regulation PTBP2 TLR7 22962607 2667980 We could show that *induced* [DCs] are characterized by a predominance of costimulatory over coinhibitory molecules and by high secretion of IL-12p70 , but not IL-10 . Positive_regulation PTBP2 TLR7 22962607 2668020 By means of IL-12p70 secretion , only *induced* [DCs] activated NK cells . Positive_regulation PTBP2 TLR7 23257360 2724758 Given the expansion of CD11c+ DCs during the progression of atherosclerosis and the key role of T cell activation in atherogenesis , we sought to understand the *role* of signaling in CD11c+ [DCs] in atherosclerosis . Positive_regulation PTBP2 TLR7 23291967 2769323 IRF5 deficiency reduces IFN-a , IFN-ß and IL-6 production by Toll-like receptor 9 (TLR9)- and *stimulated* [DCs] and reduces TLR7- and TLR9 induced IL-6 production by B cells to a similar extent in the two lines . Positive_regulation PTBP2 TLR7 23791643 2807827 The intracellular signaling molecule TRAF6 is critical for mediated *activation* of [dendritic cells (DCs)] . Positive_regulation PTBP2 TNF 10201904 605656 Dual *stimulations* of monocyte derived [DCs] with and IL-10 selectively antagonized their respective effects on these DC properties . Positive_regulation PTBP2 TNF 11035052 740872 Contrasting with our previous report using cultured splenic DCs , freshly isolated splenic [DCs] killed YAC-1 cells using a Ca ( 2+ ) -independent mechanism , but this function did not appear *mediated* by Fas ligand , TNF related apoptosis inducing ligand , or . Positive_regulation PTBP2 TNF 11369638 817512 Here it is reported that prostaglandin E ( 2 ) ( PGE ( 2 ) ) , an inflammatory mediator with a previously known Th2 driving function , dose-dependently enhances the IL-12p40 mRNA expression and the secretion of IL-12p40 protein in human *stimulated* immature [dendritic cells (DCs)] . Positive_regulation PTBP2 TNF 11369638 817516 In addition to the selective induction of IL-12p40 in *stimulated* [DCs] , PGE ( 2 ) inhibited the production of IL-12p70 and IL-12p40 in DCs stimulated with LPS or CD40 ligand . Positive_regulation PTBP2 TNF 11781361 900315 In conclusion , this study describes that stimulation by *results* in incompletely matured [DCs] ( semi-mature DCs ) which induce peptide-specific IL-10 producing T cells in vivo and prevent EAE . Positive_regulation PTBP2 TNF 11849317 912766 In this assay we analysed the migratory ability of interleukin-4 (IL-4)/granulocyte macrophage-colony stimulating factor ( GM-CSF ) -derived immature DCs as well as mature [DCs] , *induced* by and modified vaccinia virus Ankara ( MVA ) . Positive_regulation PTBP2 TNF 12471118 1023038 Further characterization of MTSA differentiated DCs showed that they were immature in nature , as *stimulation* of these [DCs] with , anti-CD40 , or LPS further up-regulated the surface levels of various molecules together with an increase in their T cell stimulatory capacity . Positive_regulation PTBP2 TNF 12662282 1074296 [DCs] cultured in serum-free media from adherent or CD14+ apheresis MNCs ( n = 36 ) in the *presence* of GM-CSF + IL4 +/- were frozen and stored at -80 degrees C in 6-percent HES , 5-percent DMSO , and 4-percent HSA . Positive_regulation PTBP2 TNF 12832450 1105602 Phenotypic activation of [DCs] exposed to PrP ( 106-126 ) is partly a *result* of an autocrine response and results in an increased ability of these cells to induce lymphocyte proliferation . Positive_regulation PTBP2 TNF 12928370 1131961 , but not IL-1 , *induce* monocytes to become [DCs] despite the presence of fibroblasts . Positive_regulation PTBP2 TNF 12928370 1131969 *induced* [DCs] contain Langerin positive cells and are able to induce allogenic T cell proliferation . Positive_regulation PTBP2 TNF 14611814 1162834 Increasing enhanced the survival of culturing stem cells and *resulted* in a parallel increase in day 14 [DCs] . Positive_regulation PTBP2 TNF 14632659 1170658 SB203580 , a specific inhibitor of p38 MAPK , partially or markedly inhibited the phenotypic changes of [DCs] *induced* by or DNCB , respectively . Positive_regulation PTBP2 TNF 15193925 1259636 Individual expression of human SLAM , interferon alpha/beta receptor , , and lymphotoxin-alpha or beta from T cells was not *required* for MV-infected [DCs] to inhibit the proliferation of T cells . Positive_regulation PTBP2 TNF 15560757 1341026 *Stimulation* of day 8 [DCs] from AD patients with and IL-1beta enhanced the expression of CD83 and CD86 and restored the production of IL-16 . Positive_regulation PTBP2 TNF 15726369 1389625 Mature [Mo-DCs] ( mMo-DCs ) were *induced* from imMo-DCs with and prostaglandin E ( 2 ) . Positive_regulation PTBP2 TNF 15730393 1377475 However , *stimulated* [DCs] produce low levels of IL-12 . Positive_regulation PTBP2 TNF 15766407 1383660 [DCs] *induced* by GM-CSF+IL-4 and had DC-classical phenotypic characteristics . Positive_regulation PTBP2 TNF 16388755 1505799 [DCs] in peripheral blood mononuclear cells ( PBMCs ) from gastric cancer patients were *induced* with rhGM-CSF , rhIL-4 and . Positive_regulation PTBP2 TNF 17113033 1667779 Our data showed that transcript and protein of DDR2 were expressed constitutively in immature DCs and upregulated in *stimulated* mature [DCs] . Positive_regulation PTBP2 TNF 18056756 1943907 *stimulated* [DCs] have been shown to restore tolerance in experimental autoimmune encephalomyelitis and collagen induced arthritis ( CIA ) . Positive_regulation PTBP2 TNF 18180802 1883487 The results show that the T-HSP70 is capable of maturing human [DCs] *inducing* an increase in the expression level of the CD83 , CD86 and human leukocyte antigen-DR surface markers , as well as in the secretion of interleukin (IL)-12 , and IL-6 cytokines . Positive_regulation PTBP2 TNF 18318992 1881051 Differential expression patterns of PD-L1 and PD-L2 were found when [DCs] were *triggered* by CD40 ligand and . Positive_regulation PTBP2 TNF 18318992 1881059 PD-L1 expression was repressed and PD-L2 expression remained unchanged in mature CD40 ligated DCs , whereas *stimulated* [DCs] kept high expression of PD-L1 and significantly enhanced PD-L2 expression on DCs . Positive_regulation PTBP2 TNF 19058839 2023986 Using real-time RT-PCR and HPLC , the expression and activity of IDO were assessed in *induced* mature [DCs] from HDM-sensitive and nonatopic patients with asthma in response to Der p 1 exposure ex vivo . Positive_regulation PTBP2 TNF 19710690 2186338 In accordance with the elevated MMP-9 release , on co-culture with TNFalpha/IL-1beta stimulated fibroblasts , DCs migrated significantly more effectively through matrigel matrices than did *stimulated* [DCs] . Positive_regulation PTBP2 TNF 20237317 2265979 Sustained secretion is *essential* for robust T-cell activation by [DCs] . Positive_regulation PTBP2 TNF 20386470 2245237 LPS stimulation of [DCs] *induced* IL-10 , IL-12p70 , and IL-1beta secretion , and taxol pretreatment modified this response by down regulating IL-1beta secretion whereas colchicine induced a proinflammatory cytokine profile with reduced IL-10 and increased IL-12p70 and TNFalpha secretion . Positive_regulation PTBP2 TNF 20943074 2332965 [DCs] from healthy human peripheral monocytes ( PBMCs ) were *induced* in vitro with rhGM-CSF , rhIL-4 , Flt3-L and . Positive_regulation PTBP2 TNF 22257833 2564427 We also noted elevated levels of inflammatory mediators , of which *activates* [DCs] and endothelial cells-was the highest . Positive_regulation PTBP2 TNF 22486596 2606868 Here , we show that parasite GPIs efficiently activate [DCs] through TLR2 mediated signalling mechanism and *induce* the production of and IL-12 . Positive_regulation PTBP2 TNF 7561684 324227 These [CFU-DCs] can be expanded for several weeks by in vitro culture with c-kit-ligand , and their differentiation *requires* exogenous in addition to GM-CSF . Positive_regulation PTBP2 TNF 8542932 338745 We show that the *dependent* ex vivo generation of [DCs] from mobilized CD34+ cells is 2.5-fold enhanced by flk-2/flt-3 ligand or c-kit ligand ( stem cell factor ) and five-fold enhanced by a combination of these growth factors . Positive_regulation PTBP2 TNFSF10 11035052 740873 Contrasting with our previous report using cultured splenic DCs , freshly isolated splenic [DCs] killed YAC-1 cells using a Ca ( 2+ ) -independent mechanism , but this function did not appear *mediated* by Fas ligand , , or TNF-alpha . Positive_regulation PTCH1 ZFP57 22391310 2566641 Consistently , overexpression of either in MPLB cells or in Xenopus and mouse embryos strongly *repressed* [Ptch1] expression . Positive_regulation PTEN ARSA 23867870 2830024 Data showed <5-ASA> *induced* peroxisome proliferator activated receptor ? DNA binding to the [PTEN] promoter ( chromatin immunoprecipitation ) and reduced both phosphorylated and oxidized ( inactive ) PTEN protein levels . Positive_regulation PTEN ARSA 23867870 2830030 Therefore , <5-ASA> reduces CUC induced reactive oxygen species in colonic progenitor cells and *enhances* [PTEN] activity , thus attenuating PI3K/Akt signaling . Positive_regulation PTEN ID1 19079342 2030884 negatively *regulated* both p53 and [PTEN] at the transcriptional level . Positive_regulation PTEN ID1 19079342 2030890 In promoter assay with serial deletion and chromatin immunoprecipitation assay , the binding of p53 to the PTEN promoter was reduced by Id-1 , suggesting that *regulates* [PTEN] transcription through its p53 modulation . Positive_regulation PTEN PTGER2 15539459 1360649 Increased [PTEN] activity in *response* to stimulation is associated with decreased tyrosine phosphorylation on PTEN , a mechanism known to regulate enzyme activity . Positive_regulation PTEN TNF 14569058 1186292 Cilostazol enhances casein kinase 2 phosphorylation and suppresses *induced* increased [phosphatase and tensin homolog] deleted from chromosome 10 phosphorylation and apoptotic cell death in SK-N-SH cells . Positive_regulation PTEN TNF 14569058 1186293 This study shows the signaling pathway by which cilostazol suppresses *induced* the [phosphatase and tensin homolog] deleted from chromosome 10 ( PTEN ) phosphorylation and apoptosis via casein kinase 2 (CK2) phosphorylation in the SK-N-SH cells ( neuroblastoma cells ) . Positive_regulation PTEN TNF 16472148 1523701 Further , cilostazol prevented *induced* [PTEN] phosphorylation and apoptotic cell death via increased CK2 phosphorylation in the SK-N-SH cells . Positive_regulation PTEN TNF 17334236 1707599 However , here we show the opposite finding that *upregulates* [PTEN] via activation of NF-kappaB in human leukemic cells . Positive_regulation PTEN TNF 17334236 1707600 *increased* [PTEN] expression at HL-60 cells in a time- and dose dependent manner , but the response was abolished by disruption of NF-kappaB with p65 antisense phosphorothioate oligonucleotide or pyrrolidine dithiocarbamate . Positive_regulation PTEN TNF 17334236 1707604 We conclude that *induces* upregulation of [PTEN] expression through NF-kappaB activation in human leukemic cells . Positive_regulation PTF1A CPA4 16896938 1607824 Adenovirus mediated expression of ngn3 ( also known as Neurog3 ) and [Ptf1a] in these cells *induced* expression of insulin and somatostatin , and of , respectively . Positive_regulation PTGDR2 TNF 21835268 2495742 PGD2 exhibited a typical bell shape dose response in attracting eosinophil from AR patients with optimal activity at 10 ( -7 ) M. Eol-1 cell surface expression of [CRTH2] was significantly *up-regulated* by 10 ng/ml IFN-? and . Positive_regulation PTGDS IL1B 12488457 1056364 The [L-PGDS] gene expression was *up-regulated* slowly by to the maximum level at 24 h . Positive_regulation PTGDS IL1B 15213234 1289079 [PG D2 synthase] mRNA expression was *up-regulated* by , TNF-alpha , or nitric oxide . Positive_regulation PTGDS IL1B 19094210 2006806 The *upregulation* of [L-PGDS] by was blocked by the translational inhibitor cycloheximide , indicating that this effect is indirect , requiring de novo protein synthesis . Positive_regulation PTGDS IL1B 19094210 2006808 Specific inhibitors of the MAPK p38 ( SB 203580 ) and c-jun N-terminal kinase ( JNK ) ( SP600125 ) and of the NF-kappaB ( SN-50 ) and Notch ( DAPT ) signalling pathways suppressed *induced* upregulation of [L-PGDS] expression . Positive_regulation PTGDS IL1B 19094210 2006810 We also found that PGD2 prevented *induced* upregulation of [L-PGDS] expression . Positive_regulation PTGDS TNF 15213234 1289078 [PG D2 synthase] mRNA expression was *up-regulated* by IL-1beta , , or nitric oxide . Positive_regulation PTGER1 IL1B 10467171 640694 These findings indicate that IL-1beta induced IL-6 production in MG-63 cells involves the following sequence of steps : *induced* COX-2 activation , PGE ( 2 ) production , and [EP-1] receptor signaling prior to IL-6 production . Positive_regulation PTGER1 IL1B 9352015 461205 Based on these results , it is proposed that and IL-4 may be *involved* in the initiation and promotion of labor by inducing [EP1] levels and PGE2 production in amnion . Positive_regulation PTGER1 PTGER2 24035156 2857142 In general , [EP1] and EP3 *induce* smooth muscle contraction whereas and EP4 induce smooth muscle relaxation . Positive_regulation PTGER1 PTGER2 8612504 353143 [EP1] promotes cell growth , and and EP4 *mediate* differentiation of the osteoblast . Positive_regulation PTGER2 CGA 18543285 2010442 Thus , this study reports for the first time in mares that the ovulatory process is accompanied by the *dependent* up-regulation of [PTGER2] and PTGER4 , which may in turn regulate PGE2 mediated preovulatory effects . Positive_regulation PTGER2 CGB8 18543285 2010441 Thus , this study reports for the first time in mares that the ovulatory process is accompanied by the *dependent* up-regulation of [PTGER2] and PTGER4 , which may in turn regulate PGE2 mediated preovulatory effects . Positive_regulation PTGER2 CXCR4 20705717 2363460 Subsequently , PGE2via [PTGER2] *induces* expression of . Positive_regulation PTGER2 EDN1 15347673 1323613 In this study , we show that in HEY and OVCA 433 ovarian carcinoma cells , , through the binding with ETA receptor (ETAR) , induces prostaglandin E2 ( PGE2 ) production , as the more represented PG types , and *increases* the [expression of PGE2 receptor type 2 (EP2)] and type 4 ( EP4 ) . Positive_regulation PTGER2 GRAP2 18597804 1959468 While inhibition of PI3K suppressed UVB induced mPGES-1 and CRTH2 expression , JNK inhibition suppressed mPGES-1 , PGIS , EP2 and CRTH2 , and kinase inhibition only *suppressed* EP1 and [EP2] . Positive_regulation PTGER2 IL6 10796889 689776 The data indicate that an *mediated* induction of the previously not expressed [EP2-R] and EP4-R on hepatocytes might establish a prostanoid mediated feedback inhibition loop for the attenuation of the acute phase response . Positive_regulation PTGER2 IL6 21209948 2359483 PGE2 *induces* in orbital fibroblasts through [EP2] receptors and increased gene promoter activity : implications to thyroid associated ophthalmopathy . Positive_regulation PTGER2 LIF 17525067 1762102 Moreover , stimulation with *up-regulated* EP1 , [EP2] and EP4 expression in HTR-8/SVneo cells . Positive_regulation PTGER2 PGD 15646041 1349868 A marked , concentration dependent induction of [EP2-R] mRNA expression was *promoted* by PGE2 , or PGF2alpha after 4 h , whereas EP1-R , EP3-R and EP4-R transcript levels were unaffected . Positive_regulation PTGER2 PGF 15646041 1349869 A marked , concentration dependent induction of [EP2-R] mRNA expression was *promoted* by PGE2 , PGD2 or after 4 h , whereas EP1-R , EP3-R and EP4-R transcript levels were unaffected . Positive_regulation PTGER2 PRKACB 14527510 1148867 The inhibitory effect of PGE2 is mediated by the [EP2] and EP4 receptors , and *involves* both signaling and mediation by DC-derived IL-10 . Positive_regulation PTGER2 PRKACB 16998801 1666294 These results suggest that PGE ( 2 ) inhibits CSE induced apoptosis via [EP(2)] receptor activation and *activation* of , which leads to an alteration in the balance between pro- and anti-apoptotic factors . Positive_regulation PTGER2 PRKACG 14527510 1148868 The inhibitory effect of PGE2 is mediated by the [EP2] and EP4 receptors , and *involves* both signaling and mediation by DC-derived IL-10 . Positive_regulation PTGER2 PRKACG 16998801 1666295 These results suggest that PGE ( 2 ) inhibits CSE induced apoptosis via [EP(2)] receptor activation and *activation* of , which leads to an alteration in the balance between pro- and anti-apoptotic factors . Positive_regulation PTGER2 PRKAR1A 14527510 1148869 The inhibitory effect of PGE2 is mediated by the [EP2] and EP4 receptors , and *involves* both signaling and mediation by DC-derived IL-10 . Positive_regulation PTGER2 PRKAR1A 16998801 1666296 These results suggest that PGE ( 2 ) inhibits CSE induced apoptosis via [EP(2)] receptor activation and *activation* of , which leads to an alteration in the balance between pro- and anti-apoptotic factors . Positive_regulation PTGER2 PRKAR1B 14527510 1148870 The inhibitory effect of PGE2 is mediated by the [EP2] and EP4 receptors , and *involves* both signaling and mediation by DC-derived IL-10 . Positive_regulation PTGER2 PRKAR1B 16998801 1666297 These results suggest that PGE ( 2 ) inhibits CSE induced apoptosis via [EP(2)] receptor activation and *activation* of , which leads to an alteration in the balance between pro- and anti-apoptotic factors . Positive_regulation PTGER2 PRKAR2A 14527510 1148871 The inhibitory effect of PGE2 is mediated by the [EP2] and EP4 receptors , and *involves* both signaling and mediation by DC-derived IL-10 . Positive_regulation PTGER2 PRKAR2A 16998801 1666298 These results suggest that PGE ( 2 ) inhibits CSE induced apoptosis via [EP(2)] receptor activation and *activation* of , which leads to an alteration in the balance between pro- and anti-apoptotic factors . Positive_regulation PTGER2 PRKAR2B 14527510 1148872 The inhibitory effect of PGE2 is mediated by the [EP2] and EP4 receptors , and *involves* both signaling and mediation by DC-derived IL-10 . Positive_regulation PTGER2 PRKAR2B 16998801 1666299 These results suggest that PGE ( 2 ) inhibits CSE induced apoptosis via [EP(2)] receptor activation and *activation* of , which leads to an alteration in the balance between pro- and anti-apoptotic factors . Positive_regulation PTGER2 PTGER1 8612504 353145 promotes cell growth , and [EP2] and EP4 *mediate* differentiation of the osteoblast . Positive_regulation PTGER2 PTGER3 17021176 1630393 Increased activation of [EP2] and decreased *activation* of by PGE2 synergistically induce an increase in cAMP level , which may induce LTP . Positive_regulation PTGER2 PTGER4 23638853 2810569 Selective stimulation of EP2 or receptors attenuates histamine evoked Ca ( 2+ ) signals , but the effects of PGE2 on both Ca ( 2+ ) signals and AC activity are largely *mediated* by [EP2] receptors . Positive_regulation PTGER2 SPAG11B 11399653 824295 We also observed that EP1 but not [EP2] is expressed in M-1 cells and levels are not *induced* by NS-398 . Positive_regulation PTGER2 TNF 19542367 2103687 RASFs expressed all four EP receptors , with selective *induction* of [EP2] by . Positive_regulation PTGER2 VEGFA 17427962 1804476 Prostaglandin E2 *induces* secretion in prostate cancer cells through [EP2] receptor mediated cAMP pathway . Positive_regulation PTGER2 WNT3A 20347274 2244820 Immunoblot further confirmed that [EP2] protein is indeed *increased* by . Positive_regulation PTGER3 IL1B 11268335 764498 Our behavioral and electrophysiological studies have revealed that in the brain *induces* hyperalgesia through the actions of prostaglandin E2 ( PGE2 ) on [EP3] receptors in the preoptic area and its neighboring basal forebrain , whereas the IL-1 beta induced analgesia is produced by the actions of PGE2 on EP1 receptors in the ventromedial hypothalamus . Positive_regulation PTGER3 IL1B 12031964 947859 Inhibition of *induced* COX-2 and [EP3] gene expression by sodium salicylate enhances pancreatic islet beta-cell function . Positive_regulation PTGER3 IL1B 16405508 1513258 Here we describe *induced* [EP3] receptor expression in human astrocytoma cells , primary astrocytes of rat and human origin and in rat brain . Positive_regulation PTGER3 IL1B 16405508 1513259 The analysis of involved signal transduction pathways by pathway-specific inhibitors revealed an essential role of protein kinase C and nuclear factor-kappaB in astrocytic *induced* [EP3] synthesis . Positive_regulation PTGER3 IL1B 19444759 2078672 [EP3] expression was not detected in either the absence or the *presence* of . Positive_regulation PTGER3 IL1B 9352015 461201 or IL-4 *had* no effect on [EP3] protein levels . Positive_regulation PTGER3 IL1B 9629255 512215 The results , taken together , suggest ( 1 ) that at lower doses in the brain *induces* hyperalgesia through [EP3] receptors in the POA and ( 2 ) that the higher doses of brain IL-1 beta produces analgesia through EP1 receptors , probably , in the VMH . Positive_regulation PTGER3 PTGER2 17021176 1630394 Increased activation of and decreased *activation* of [EP3] by PGE2 synergistically induce an increase in cAMP level , which may induce LTP . Positive_regulation PTGER3 PTGER2 24035156 2857144 In general , EP1 and [EP3] *induce* smooth muscle contraction whereas and EP4 induce smooth muscle relaxation . Positive_regulation PTGER4 EPHB2 12566441 1071743 Furthermore , this *activation* of signaling by the [EP(4)] receptors induces the functional expression of early growth response factor-1 (EGR-1) . Positive_regulation PTGER4 IL1B 10800959 690452 In a first set of experiments , animals were treated with the inhibitor of PG synthesis ketorolac to determine the endogenous contribution of PG in mediating the neuronal activation and [EP4] expression in *response* to circulating . Positive_regulation PTGER4 IL1B 11297615 801646 Indeed , the proinflammatory cytokine *stimulated* expression of EP2 and [EP4] transcripts in concentration- and time dependent manner in the GL cells . Positive_regulation PTGER4 IL1B 19444759 2078675 *increases* the production of PGE ( 2 ) , COX-2 , and the PG receptor [EP4] in cultured human chondrocytes . Positive_regulation PTGER4 IL1B 20204061 2180999 Previously , we showed that *stimulated* the expression of prostaglandin ( PG ) receptor [EP4] via increased PGE ( 2 ) production . Positive_regulation PTGER4 PTGER2 22522619 2613660 Our data uncover a previously unrecognized protective role of PTGS-2 derived PGE ( 2 ) in STZ induced diabetes *mediated* by the receptor types and [PTGER4] . Positive_regulation PTGER4 PTGER2 23638853 2810570 Selective stimulation of EP2 or [EP4] receptors attenuates histamine evoked Ca ( 2+ ) signals , but the effects of PGE2 on both Ca ( 2+ ) signals and AC activity are largely *mediated* by receptors . Positive_regulation PTGES CD14 22466648 2589007 [mPGES-1] activation , PGE2 production , and edema formation *required* ( a component of the LPS receptor ) and NFAT . Positive_regulation PTGES EPHB2 19299480 2106078 In the present study , we demonstrate that CGRP is involved in morphine tolerance by differentially regulating the *dependent* up-regulation of IL-1beta , TNF-alpha , and [microsomal prostaglandin E synthase-1] ( mPGES-1 ) in astrocytes and p38 dependent up-regulation of IL-6 in microglia in the rat spinal cord . Positive_regulation PTGES IL1B 12512699 1027685 *induces* functional [prostaglandin E synthase] in cultured human umbilical vein endothelial cells . Positive_regulation PTGES IL1B 12818365 1103662 While the ARE-specific inducer tBHQ did not modulate the basal expression of MGST1-L1 , it was found to act as an antagonist of *stimulated* [MGST1-L1] overexpression . Positive_regulation PTGES IL1B 14558087 1153674 Prostaglandin E2 is an enhancer of *induced* expression of membrane associated [prostaglandin E synthase] in rheumatoid synovial fibroblasts . Positive_regulation PTGES IL1B 15379214 1298201 The COX-2 specific inhibitor , celecoxib , in contrast to the nonspecific COX inhibitor , indomethacin , markedly reduced [mPGES-1] expression *induced* by . Positive_regulation PTGES IL1B 15457451 1301462 The specific p38alpha MAPK inhibitor SC906 suppressed *induced* COX-2 expression but not IL-1beta induced [mPGES-1] expression , suggesting preferential involvement of p38beta MAPK in IL-1beta induced mPGES-1 expression . Positive_regulation PTGES IL1B 15479233 1319772 Conversely , whereas dexamethasone and budesonide were highly effective inhibitors of *induced* cyclooxygenase [(COX)/prostaglandin E synthase (PGES)] activity and COX-2 expression , RU486 ( < 1 microm ) was a poor inhibitor , but was able to efficiently antagonize the effects of dexamethasone and budesonide . Positive_regulation PTGES IL1B 15531909 1367465 Induction of [mPGES-1] expression in *response* to was seen in cultured gastric fibroblasts in vitro , and double immunostaining showed mPGES-1 coexpression with COX-2 in fibroblasts of the ulcer bed in vivo . Positive_regulation PTGES IL1B 15868626 1402190 Peroxisome proliferator activated receptor-gamma ligands , 15-deoxy-delta ( 12,14 ) -prostaglandin J2 and troglitazone , inhibited *induced* [mPGES-1] protein expression , an effect that was reversed by exogenous PGE2 . Positive_regulation PTGES IL1B 16081677 1466263 *induced* [microsomal prostaglandin E synthase 1] ( mPGES-1 ) and cyclooxygenase-2 were attenuated by curcumin at the protein and mRNA levels , but a more dramatic inhibition of mPGES-1 expression was observed at lower concentrations of curcumin in A549 human lung epithelial cells . Positive_regulation PTGES IL1B 16766159 1654012 The results showed that and TNFalpha *induce* the expression of [mPGES-1] without inducing the expression of early growth response factor-1 (Egr-1) . Positive_regulation PTGES IL1B 17186945 1695296 Using specific PPARgamma agonist ( rosiglitazone ) , PPARgamma ligand ( 15-deoxy-Delta12,14-PGJ ( 2 ) ) , and PPARgamma inhibitor ( GW9662 ) , we confirm that activation of PPARgamma blocks *induced* up-regulation of COX-2 , [mPGES-1] , and their derived PGE ( 2 ) . Positive_regulation PTGES IL1B 19802674 2148239 markedly *enhanced* the expression of COX-2 and [microsomal prostaglandin E synthase-1] ( mPGES-1 ) at both the mRNA and protein levels . Positive_regulation PTGES IL1B 20590617 2285839 All p38MAPK inhibitors significantly inhibited the *induced* gene expression of COX-2 , [mPGES1] , iNOS , matrix metalloproteinase 13 (MMP13) and TNFRSF11B , as well as PGE ( 2 ) release . Positive_regulation PTGES MAP2K6 16598755 1598209 Inhibition of PKC activity , activity , or Ca2+ signaling *blocked* agonist induction of COX-2 and [mPGES-1] . Positive_regulation PTGES MAP2K6 17708577 1866026 The PAR2 triggered up-regulation of [mPGES-1] was *suppressed* by inhibitors of COX-1 , cytosolic phospholipase A(2) ( cPLA(2) ) and , but not COX-2 . Positive_regulation PTGES TNF 14722058 1219630 Moreover , *induced* [mPGES-1] by stimulating PC-PLC -- > PKC -- > NO -- > cGMP -- > PKG signal transduction pathway . Positive_regulation PTGES TNF 15642051 1363018 The cytokine *enhanced* the expression of mRNA as well as the protein levels of both COX-2 and [mPGES-1] and subsequently the production of PGE2 in gingival fibroblasts . Positive_regulation PTGES TNF 16766159 1654011 The results showed that IL-1beta and *induce* the expression of [mPGES-1] without inducing the expression of early growth response factor-1 (Egr-1) . Positive_regulation PTGES TNF 16816110 1580950 *induced* COX-2 and [mPGES-1] expression in neurons , followed by formation of PGE2 , which was blocked by a selective COX-2 inhibitor . Positive_regulation PTGES TNF 16816110 1580952 SC-560 treatment neither altered *induced* COX-2 or [mPGES-1] expression nor did the addition of the calcium ionophore A23187 or arachidonic acid reverse the inhibition by SC-560 . Positive_regulation PTGES TNF 19415240 2089857 Furthermore , OGD and the NF-kappaB activator *stimulated* the expression of cPLA-2 , cyclooxygenase-2 (COX-2) , and [mPGES-1] and increased the release of PGE ( 2 ) from neurons . Positive_regulation PTGES TNF 20116443 2258834 IL1beta , and LPS *enhanced* the expression of COX-2 and [mPGES1] whereas phorbol ester enhanced COX-2 expression only . Positive_regulation PTGES TNF 20616214 2321732 *stimulated* PTGS2 and mPGES-1 mRNA , as well as [mPGES-1] protein expression and PGE ( 2 ) release on days 11-12 of pregnancy and the estrous cycle . Positive_regulation PTGES TNF 21075851 2376681 Interestingly , we found that activation of E-prostanoid (EP)2 and EP4 receptors , but not EP1 , EP3 , PGI(2) receptor ( IP ) , thromboxane A(2) receptor ( TP ) , PGD(2) receptor ( DP ) , and PGF ( 2 ) receptor ( FP ) , efficiently blocked LPS induced synthesis and COX-2 and [mPGES-1] *induction* as well as prostaglandin synthesis in spinal cultures . Positive_regulation PTGES TNF 21435451 2406390 In *response* to ( TNF-a ) , IL-1ß , and cocultured lymphocytes , however , [mPGES-1] and COX-2 protein expression increased in fibroblasts and smooth muscle cells , accompanied by increased PGE ( 2 ) , whereas mPGES-2 and cPGES were unaffected . Positive_regulation PTGES TNF 22227567 2550712 Matrix metalloproteinase dependent [microsomal prostaglandin E synthase-1] expression in macrophages : *role* of and the EP4 prostanoid receptor . Positive_regulation PTGES TNF 22608768 2681541 Lipopolysaccharides , , IL-1a , and the reagents combination *increased* PTGS2 , [PTGES] , and PGFS mRNA transcription ( P < 0.01 ) , whereas ALOX5 mRNA transcription was increased only by TNF ( P < 0.001 ) . Positive_regulation PTGES3 EPHB2 14708611 1181145 Inhibition of , Src , or Akt *suppressed* [telomerase] activity in HSC-1 cells , but to a lesser extent than did treatment with AG 1478 . Positive_regulation PTGES3 ID1 10449746 637376 We demonstrate that ectopic expression of *leads* to activation of [telomerase] activity and immortalization of primary human keratinocytes . Positive_regulation PTGES3 ID1 10908559 722491 Under these experimental conditions , expression did not *trigger* induction of [telomerase] activity , and there was progressive shortening of the telomeres that was accompanied by elevated p16 levels and prevalence of active Rb . Positive_regulation PTGES3 IFI27 14612944 1163394 Overexpression of *suppressed* [telomerase] activity in tumor cells . Positive_regulation PTGES3 RARB 14586406 1159570 Our previous work showed that acquisition of immortality at the dysplasia stage of oral cancer progression was consistently associated with four changes : loss of and p16INK4A expression , p53 mutations and *activation* of [telomerase] . Positive_regulation PTGES3 TNF 15020249 1221501 *induces* rapid activation and nuclear translocation of [telomerase] in human lymphocytes . Positive_regulation PTGES3 TNF 15020249 1221514 In this study , we show that tumor necrosis factor alpha (TNFalpha) induces telomerase activity in the cytoplasm of peripheral blood lymphocytes ( PBL ) at 60 min , followed by translocation of activated telomerase to the nucleus at 120 min. Conversely , the phosphoinositol 3-kinase (PI3K) inhibitor wortmannin blocks *induced* activation of [telomerase] , whereas the specific NF-kappaB translocation inhibitor SN-50 blocks TNFalpha induced nuclear translocation of activated telomerase . Positive_regulation PTGES3 TNF 15326480 1296851 The present study described that , in the leukemic KG1 cells , *induced* no apoptosis but a senescence state characterized by prolonged growth arrest , increased beta-galactosidase activity , p21WAF-1 induction , decreased [telomerase] activity , telomeric disturbances ( shortening , losses , fusions ) , and additional chromosomal aberrations . Positive_regulation PTGES3 TNF 19299722 2051937 Here , we show that modulation of levels in long-term cultures of human CD8 ( + ) T lymphocytes , by chronic exposure either to a neutralizing Ab or to an inhibitor of the TNF-alpha receptor-1 , increases proliferative potential , delays loss of CD28 expression , retards cytokine profile changes , and *enhances* [telomerase] activity . Positive_regulation PTGES3 ZFP57 20235149 2244347 Constitutive expression of in C2C12 myoblasts *increased* mTERT expression and [telomerase] activity , and promoted the progression of the cell cycle and cell proliferation . Positive_regulation PTGFR IL1B 16855208 1632227 These results are consistent with the proposal that proinflammatory cytokines directly regulate uterine activation genes and that the transcription factor NFkappaB is involved in both basal and *stimulated* transcription of the [PTGFR] gene . Positive_regulation PTGIS CPOX 11181435 785188 3. The non-selective inhibitor , indomethacin , a selective COX-2 inhibitor NS-398 or the [prostacyclin synthase] *inhibitor* , tranylcypromine ( 10 mg x kg ( -1 ) ) , markedly reduced the inhibitory properties of endothelin-1 , whereas only a combination of both indomethacin , NS-398 or tranylcypromine and L-NAME ( 10 mg x kg ( -1 ) ) were required to abolish the response to bradykinin . Positive_regulation PTGS1 IL1B 11108281 756833 After 4 h of stimulation , *induced* gene expression of cyclooxygenase-2 (COX-2) but not [cyclooxygenase-1 (COX-1)] . Positive_regulation PTGS1 IL1B 11686835 875881 In contrast , *had* no effect on the level of the constitutively expressed [COX-1] . Positive_regulation PTGS1 IL1B 11863390 917488 We have shown that *induces* the in vitro expression of genes believed to play important role in ovulation ( IL-1 beta itself , its receptors , IL-1 beta receptor antagonist , glucose transporters 1 and 3 , secretory and cytosolic phospholipase A(2) , [prostaglandin endoperoxide synthase 1] and 2 ) . Positive_regulation PTGS1 IL1B 15313472 1285553 However , neither , TNF-alpha , IL-6 nor a combination of IL-1beta , TNF-alpha , IL-6 *enhanced* [COX-1] mRNA levels in calvarial osteoblasts . Positive_regulation PTGS1 IL1B 16141635 1454860 DHA and eicosapentaenoic acid slightly enhanced *induced* cyclooxygenase (COX)-2 , but not [COX-1] , expression , whereas arachidonic acid had no effect . Positive_regulation PTGS1 IL1B 16948668 1610111 *stimulated* the COX-2 but not [COX-1] mRNA expression . Positive_regulation PTGS1 IL1B 17077517 1642377 stimulation *increased* the protein , activity and mRNA expression of cyclooxygenase (COX)-2 but not [COX-1] . Positive_regulation PTGS1 IL1B 22572995 2638060 *increased* expression of [PTGS1] and PTGS2 genes that are rate limiting for PG synthesis in the uterine endometrium . Positive_regulation PTGS1 IL1B 22572995 2638065 Collectively , the results indicated that regulates expression of IL1R1 and IL1RAP and *stimulates* expression of [PTGS1] and PTGS2 that are considered to be the most rate limiting enzymes for endometrial synthesis of PGs during the peri-implantation period of pregnancy in pigs . Positive_regulation PTGS1 IL1B 7873203 296659 These results indicate that *induces* cyclooxygenase-2 rather than [cyclooxygenase-1] in IMR-90 cells and this induction is responsible for the augmentation of PGE2 production stimulated with IL-1 beta . Positive_regulation PTGS1 IL1B 8274023 239527 In rat vascular smooth muscle cells , selectively *increased* the expression of COX-2 , but not that of [COX-1] , as assessed by enzyme activity , immunoprecipitation of COX proteins , and mRNA analysis . Positive_regulation PTGS1 IL1B 8872612 389692 Prostaglandin E2 , transforming growth factor-beta , and variably *regulate* the expression of [cyclooxygenase 1] , cyclooxygenase 2 , and lysyl oxidase in IMR90 , human embryo lung fibroblasts . Positive_regulation PTGS1 IL1B 9633531 513127 Analysis of fibroblast proteins showed the induction of [cyclooxygenase-1 (Cox-1)] by TGF-beta 1 and the *induction* of Cox-2 by and TNF-alpha . Positive_regulation PTGS1 TNF 14975359 1212874 Interleukin (IL)-1beta ( 25 ng/ml ) , IL-8 ( 25 ng/ml ) , growth related oncogene-alpha ( GRO , 50 ng/ml ) and ( TNF-alpha , 25 ng/ml ) *stimulated* the [COX-1] protein production as demonstrated by Western blot and enhanced PGE2 synthesis in GMC , beginning on 2 h of incubation , and steadily enhanced TXB2 synthesis over a 24-h period . Positive_regulation PTGS2 ALOX5 15161935 1295145 However , <5-lipoxygenase> inhibition had no effect on alpha7-nAChR mRNA expression , but significantly *inhibited* cell proliferation and activation of NF-kappaB and [cyclooxygenase-2] , whereas NF-kappaB-specific inhibitor caffeic acid phenethyl ester reduced both cell proliferation and cyclooxygenase expression induced by NNK without affecting alpha7-nAChR mRNA level and 5-lipoxygenase expression . Positive_regulation PTGS2 ALOX5 17720770 1816971 The low PUFA diet ( % energy , 1.2 % LA+0.06 % ALA ) increased arachidonic acid ( AA ) and decreased eicosapentaenoic acid ( EPA ) in heart membranes and increased Ca ( 2+ ) -independent iPLA(2) activity , [COX-2] expression , and *activation* of <5-LO> . Positive_regulation PTGS2 ALOX5 17766677 1822815 Separate administration of 4-[5- ( 4-chlorophenyl ) -3- ( trifluoromethyl ) -1H-pyrazol-1-yl ] benzenesulfonamide ( SC-236 ) , a selective [COX-2] *inhibitor* , and CJ-13,610 , a <5-LO> inhibitor , to carbon tetrachloride treated mice significantly reduced fibrosis as revealed by the analysis of Sirius Red stained liver sections without affecting necroinflammation . Positive_regulation PTGS2 ANGPT1 24799613 2944659 P < 0.05 ) and prevalence of subarachnoid hemorrhage ( from 75 % to 48 % ; P < 0.05 ) . In cerebral arteries , expression of the inflammatory markers , Nox2 and catalase increased similarly in elastase+Ang II or elastase+Ang II+Ang 1-7 groups. *increased* the expression of [cyclooxygenase-2] and decreased the expression of matrix metalloproteinase-9 induced by elastase+Ang II ( P < 0.05 ) . In Mas receptor-deficient mice , systolic blood pressure , mortality , and prevalence of subarachnoid hemorrhage were similar ( P > 0.05 ) in groups treated with elastase+Ang II or elastase+Ang II+Ang 1-7 . Positive_regulation PTGS2 ARSA 14633677 1170789 Interestingly , *induced* [COX-2] expression , although it had no effect on COX-1 . Positive_regulation PTGS2 ARSA 16804302 1591044 *induced* both damage and [COX-2] expression in the stomach when given p.o. but not s.c. , despite decreasing the PGE ( 2 ) level similarly via either route of administration . Positive_regulation PTGS2 ARSA 17218764 1664118 Both and ASA-VitC *stimulated* the [COX-2] expression in the gastric mucosa . Positive_regulation PTGS2 ARSA 19576865 2142564 [COX-2] expression was *induced* by , protein kinase C inhibitors reversed this induction . Positive_regulation PTGS2 CA12 20600917 2320483 Three sulphonamides , celecoxib itself , furosemide ( a loop diuretic ) , acetazolamide ( a inhibitor ) , or a selective [COX-2] *inhibitor* lacking the sulphonamide group , lumiracoxib , were injected s.c. , 30 min before the pro-inflammatory stimulus . Positive_regulation PTGS2 CCND1 15548426 1338406 [COX-2] activity is known to induce expression of cyclin D1 in neoplastic cells , and expression can *induce* cell death in postmitotic neurons . Positive_regulation PTGS2 CD14 10409292 630093 In the mIMCD-K2 cell line , LPS significantly *induced* [COX-2] mRNA expression , with concomitant induction of . Positive_regulation PTGS2 DAPK1 22868392 2671623 In human umbilical vein endothelial cells , expressions of vascular cell adhesion molecule 1 , endothelial selectin , and [cyclooxygenase 2] , as well as ROS production induced by tumor necrosis factor-a , were *inhibited* by inhibitor . Positive_regulation PTGS2 EDN2 14530261 1174631 Alterations in subcellular localization of p38 MAPK potentiates *stimulated* [COX-2] expression in glomerular mesangial cells . Positive_regulation PTGS2 EDN2 20176726 2228926 *induced* in GCs changes that characterize the developing CL : cell proliferation as well as up-regulation of vascular endothelial growth factor and [cyclooxygenase-2] ( mRNA and protein levels ) . Positive_regulation PTGS2 EDN2 8077206 270659 *stimulates* [prostaglandin endoperoxide synthase-2] mRNA expression and protein synthesis through a tyrosine kinase signaling pathway in rat mesangial cells . Positive_regulation PTGS2 EPHB2 10969080 744897 These results suggest that p38 , but not , activation is *required* for induced [Cox-2] and PPARdelta expression during decidualization . Positive_regulation PTGS2 EPHB2 11062012 746434 However , as is not *required* for IL-1beta dependent induction of [COX-2] , the mechanism of ceramide and SMase induction of COX-2 remains unclear . Positive_regulation PTGS2 EPHB2 11085935 750658 The potential *role* of in [PGHS-2] up-regulation was assessed by using cell lines expressing , both stably and after adenoviral infection , constitutively active forms of its upstream activator MAPK/ERK kinase ( MEK1 ) . Positive_regulation PTGS2 EPHB2 11292836 819919 Bombesin stimulation of [COX-2] expression *requires* an increase in [ Ca ( 2+ ) ] ( i ) , activation of extracellular signal regulated kinase ( ) -1 and -2 and p38 ( MAPK ) , and increased activation and expression of the transcription factors Elk-1 , ATF-2 , c-Fos , and c-Jun . Positive_regulation PTGS2 EPHB2 11439356 833220 *Role* of p38 MAP kinases and in mediating ultraviolet-B induced [cyclooxygenase-2] gene expression in human keratinocytes . Positive_regulation PTGS2 EPHB2 11813157 907409 however , different patterns of response were observed as regards activation of the kinase , triggering of the NF-kappaB/Rel system , production of chemotactic cytokines , and *induction* of the expression of [cyclooxygenase-2 (COX-2)] . Positive_regulation PTGS2 EPHB2 11880271 919305 Activation of nuclear factor-kappaB (NF-kappaB) , extracellular signal regulated protein kinase ( ) , p38 , and protein kinase C ( PKC ) signaling pathways was each *necessary* for optimal [COX-2] induction . Positive_regulation PTGS2 EPHB2 12377986 997065 Vomitoxin induced [cyclooxygenase-2] gene expression in macrophages *mediated* by activation of and p38 but not JNK mitogen activated protein kinases . Positive_regulation PTGS2 EPHB2 12377986 997066 The inhibitor PD98059 and p38 inhibitor SB203580 *suppressed* VT-induced PGE ( 2 ) and [COX-2] protein expression , whereas impairment of JNK function by transient transfection with a dominant negative ( dn ) JNK vector had no effect on COX-2 protein expression . Positive_regulation PTGS2 EPHB2 12670830 1106027 Pharmacological inhibition of activation partially *blocked* tonicity dependent [COX-2] expression . Positive_regulation PTGS2 EPHB2 12891702 1117754 Also , gastrin dependent [COX-2] expression did not *require* PKC activity , activation of , or transactivation of EGFR . Positive_regulation PTGS2 EPHB2 14713309 1181666 Furthermore , we show that ethanol induced activation *triggers* the stimulation of [cyclo-oxygenase-2 (COX-2)] and the release of prostaglandin E2 , and that blockade of the mitogen activated protein kinase kinase ( MEK ) /ERK pathway by PD98059 abolishes the up-regulation of COX-2 induced by ethanol plus ceramide , and decreases the ethanol induced apoptosis . Positive_regulation PTGS2 EPHB2 14984736 1214720 The and p38 MAPKs can also *stimulate* the expression of both [cyclooxygenase-2 (Cox-2)] and interleukin-8 (IL-8) . Positive_regulation PTGS2 EPHB2 14998726 1216738 Furthermore , we found that PD98059 , an pathway inhibitor , and SB203580 , a p38 MAPK inhibitor , *diminished* AAPH induced [COX-2] expression and PGE ( 2 ) production , whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH . Positive_regulation PTGS2 EPHB2 15231484 1289379 Acid induced activation of both and p38 *causes* a significant increase in [COX-2] promoter activity , and acid activated ERK stabilizes COX-2 mRNA . Positive_regulation PTGS2 EPHB2 15319299 1341724 Consistent with our animal model , an in vitro study also demonstrated that incubation with nicotine ( 50-200 microg/ml ) for 5 h stimulated cell proliferation dose-dependently and increased [COX-2] expression , prostaglandin E ( 2 ) ( PGE ( 2 ) ) and VEGF release , as well as *activation* of phosphorylation . Positive_regulation PTGS2 EPHB2 16207478 1464370 PD153035 , an inhibitor of EGF receptor tyrosine kinase , and PD98059 , an inhibitor of , *attenuated* [COX-2] expression in RIE and RIE-RhoA ( 63L ) . Positive_regulation PTGS2 EPHB2 16275389 1480149 The induction of [COX-2] might be *mediated* by activation of p38 MAPK and . Positive_regulation PTGS2 EPHB2 16446079 1534201 Troglitazone induction of [COX-2] expression is *dependent* on activation in keratinocytes . Positive_regulation PTGS2 EPHB2 17574271 1792285 In vitro , Ro26-2198 inhibited IL-1beta induced activation and [COX-2] *induction* and decreased HCA-7 cell proliferation . Positive_regulation PTGS2 EPHB2 17592548 1764679 We previously reported that the epidermal growth factor receptor (EGFR) is overexpressed in papilloma cells , that cyclooxygenase-2 (COX-2) is induced , and that [COX-2] expression in primary papilloma cells *requires* activation of the EGFR but not . Positive_regulation PTGS2 EPHB2 17604021 1774693 Furthermore , U0126 , an pathway inhibitor , and SB203580 , a p38 MAPK inhibitor , *diminished* EGF induced [COX-2] expression ; Positive_regulation PTGS2 EPHB2 19804834 2184041 Contribution of reactive oxygen species to migration/invasion of human glioblastoma cells U87 via *dependent* [COX-2/PGE] ( 2 ) activation . Positive_regulation PTGS2 EPHB2 19808956 2154251 Inhibition of arsenite induced or JNK signaling using a pharmacologic inhibitor of ERK or JNK substantially *blocked* [COX-2] expression . Positive_regulation PTGS2 EPHB2 21807123 2495265 The COX-2 inhibitor celecoxib blocked IFN-a induced [COX-2] expression , 5-HT uptake and *activation* of Akt , and STAT . Positive_regulation PTGS2 EPHB2 23178030 2736154 ROS dependent stimulation of , JNK , NF-?B , and AP-1 activation *contributes* to P. acnes induced iNOS/NO and [COX-2/PGE2] in macrophages , and chemicals such as hispolon possessing ability to block iNOS/NO and COX-2/PGE2 production reserve potential to be further developed for treatment of the early phase of inflammation elicited by P. acnes . Positive_regulation PTGS2 EPHB2 9705357 526017 Inhibition of activity by PD 98059 also *suppressed* the induction of [COX-2] by epidermal growth factor in intestinal epithelial cells and significantly reduced the expression of COX-2 in Ha-Ras transformed rat intestinal epithelial cells . Positive_regulation PTGS2 GPR115 17868457 1810643 To determine whether increased [COX-2] expression and PGE2 production is *mediated* by the angiogenic and tumorigenic KSHV encoded ( vGPCR ) , we developed a recombinant retrovirus to express vGPCR in Human Umbilical Vascular Endothelial Cells ( HUVEC ) . Positive_regulation PTGS2 GPR132 17868457 1810632 To determine whether increased [COX-2] expression and PGE2 production is *mediated* by the angiogenic and tumorigenic KSHV encoded ( vGPCR ) , we developed a recombinant retrovirus to express vGPCR in Human Umbilical Vascular Endothelial Cells ( HUVEC ) . Positive_regulation PTGS2 GPR87 17868457 1810712 To determine whether increased [COX-2] expression and PGE2 production is *mediated* by the angiogenic and tumorigenic KSHV encoded ( vGPCR ) , we developed a recombinant retrovirus to express vGPCR in Human Umbilical Vascular Endothelial Cells ( HUVEC ) . Positive_regulation PTGS2 HBEGF 20117092 2219720 In this study , we aimed to elucidate the role and underlying mechanism of the alpha subunit of Gq protein ( Galphaq ) in UVB induced secretion and [COX-2] *induction* . Positive_regulation PTGS2 HBEGF 21244855 2414409 *enhanced* the expression of [COX-2] , a response mediated by MEK5-ERK5 signaling , while the COX-2 inhibitor rofecoxib attenuated HB-EGF induced ANF mRNA expression , suggesting that COX-2 is also associated with HB-EGF induced cardiomyocyte hypertrophy . Positive_regulation PTGS2 HBEGF 21244855 2414410 It has been known that ERK5 activates the myocyte enhancer factor (MEF) 2 family of transcription factor , we next tested whether activation of MEF2A contributes to *induced* [COX-2] expression . Positive_regulation PTGS2 HBEGF 21244855 2414412 Inhibition of MEF2A using siRNA attenuated *induced* [COX-2] , ANF expression and cell size . Positive_regulation PTGS2 HSD11B2 15718388 1402865 These data indicate that COX-2 plays a modulating role in the development of hypertension due to 11betaHSD2 deficiency and that <11betaHSD2> *regulates* renal [COX-2] expression by preventing glucocorticoid access to MRs during postnatal development . Positive_regulation PTGS2 IFI27 11756433 916233 These data suggest that [COX-2] inhibits mesangial cell proliferation by a novel mechanism that is independent of prostaglandin synthesis , but *involves* p53 , p21 ( cip-1 ) , and ( kip-1 ) . Positive_regulation PTGS2 IL1B 10082276 597719 *induced* [cyclooxygenase-2] but not cyclooxygenase-1 protein . Positive_regulation PTGS2 IL1B 10084970 599229 Glucocorticoid receptor mediated post-ceramide inhibition of the *dependent* induction of ovarian [prostaglandin endoperoxide synthase-2] in rats . Positive_regulation PTGS2 IL1B 10198245 605112 The cytokine and to a lesser extent EGF , *enhanced* [COX-2] mRNA levels in gingival fibroblasts . Positive_regulation PTGS2 IL1B 10232679 611397 Oligonucleotide decoy experiments confirmed the importance of nuclear factor kappaB (NF-kappaB) activation for [COX-2] *induction* by . Positive_regulation PTGS2 IL1B 10377395 623768 A549 cells have been used as a model system to study [cyclooxygenase-2] *induction* by . Positive_regulation PTGS2 IL1B 10383598 624630 Pretreatment with dexamethasone abolished and BK-stimulated [COX-2] *induction* in all cells studied . Positive_regulation PTGS2 IL1B 10383598 624632 Both and BK *induced* [COX-2] expression in all cells studied and this induction was blocked by dexamethasone . Positive_regulation PTGS2 IL1B 10397405 627824 These results suggest that CRE may mediate the *induction* of [PGHS-2] by and PMA as well as the suppression of expression by dexamethasone in amnion derived cells . Positive_regulation PTGS2 IL1B 10454683 638130 The nuclear transcription factor NF-kappaB mediates *induced* expression of [cyclooxygenase-2] in human myometrial cells . Positive_regulation PTGS2 IL1B 10467171 640695 These findings indicate that IL-1beta induced IL-6 production in MG-63 cells involves the following sequence of steps : induced [COX-2] *activation* , PGE ( 2 ) production , and EP-1 receptor signaling prior to IL-6 production . Positive_regulation PTGS2 IL1B 10523409 653427 *Induction* of [cyclooxygenase-2] expression in human myometrial smooth muscle cells by : involvement of p38 mitogen activated protein kinase . Positive_regulation PTGS2 IL1B 10523409 653428 Cycloheximide ( 10 microg ml-1 , 6 h ) blocked *induced* [COX-2] protein expression and super induced COX-2 mRNA expression . Positive_regulation PTGS2 IL1B 10523409 653429 3. *induced* [COX-2] expression was accompanied by a 3-fold increase of prostaglandin E2 release into the culture medium . Positive_regulation PTGS2 IL1B 10523409 653431 *Induction* of [COX-2] by in HMSMCs provides support for the hypothesis that autocrine prostaglandin signalling in the myometrium , initiated by elevated intrauterine cytokine concentrations , plays a role in regulating myometrial contractility during labour . Positive_regulation PTGS2 IL1B 10531320 562090 Since we recently observed that *induces* [cyclooxygenase-2 (COX-2)] gene expression and PGE ( 2 ) synthesis in islet beta cells , we have reassessed the possibility that PGE ( 2 ) mediates IL-1beta effects on beta function . Positive_regulation PTGS2 IL1B 10564178 567158 Consistent with these observations , *induced* [cyclooxygenase-2] expression was virtually abolished by FP at concentrations of 10 ( -10 ) M and greater , with a resultant decrease in PGE ( 2 ) formation . Positive_regulation PTGS2 IL1B 10564179 567160 ( 20 ng/ml for 22 h ) alone *caused* a marked induction of [COX-2] and increased basal PGE ( 2 ) release 28-fold ( P < 0.001 ) . Positive_regulation PTGS2 IL1B 10594073 573024 An essential *role* of in mediating NF-kappaB activity and [COX-2] transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia . Positive_regulation PTGS2 IL1B 10598013 573698 The molecular mechanism of inhibition of *induced* [cyclooxygenase-2] expression in human synovial cells by Tripterygium wilfordii Hook F extract . Positive_regulation PTGS2 IL1B 10617676 657174 Involvement of protein kinase C-gamma in *induced* [cyclooxygenase-2] expression in human pulmonary epithelial cells . Positive_regulation PTGS2 IL1B 10617676 657176 The tyrosine kinase inhibitors ( genistein and tyrphostin AG126 ) and phosphatidylcholine-phospholipase C inhibitor ( D-609 ) prevented *induced* prostaglandin E ( 2 ) ( PGE ( 2 ) ) release and [COX-2] expression , whereas U-73122 ( a phosphatidylinositol-phospholipase C inhibitor ) and propranolol ( a phosphatidate phosphohydrolase inhibitor ) had no effect . Positive_regulation PTGS2 IL1B 10724331 677486 is a potent *inducer* of [cyclooxygenase-2 (COX-2)] and prostaglandin biosynthesis in many types of cells , yet little is known about the molecular mechanisms regulating IL-1 mediated prostanoid biosynthesis in the endothelium of the microvasculature . Positive_regulation PTGS2 IL1B 10807497 692221 Augmented PGE2 production by mineralizing osteoblasts after IL-1beta treatment , and the involvement of *induced* cPLA2 , sPLA2 , [COX-2] and PGE synthase activities in this phenomenon were demonstrated . Positive_regulation PTGS2 IL1B 10810453 692773 In this study , we examined the *induction* of [COX-2] expression by and tumor necrosis factor-alpha (TNF-alpha) in human primary in vitro differentiated macrophages . Positive_regulation PTGS2 IL1B 10843735 700291 also *stimulated* expression of cPLA(2)and [COX-2] only , while constitutive and IL-1beta induced type IIA and type V secretory PLA(2)s ( sPLA(2)s ) expression could not be detected . Positive_regulation PTGS2 IL1B 10843735 700293 these cytokines apparently suppressed *stimulated* [COX-2] expression and only weakly suppressed cPLA(2)expression in response to IL-1beta . Positive_regulation PTGS2 IL1B 10942208 721288 Activation of NFkappaB is necessary for *induced* [cyclooxygenase-2 (COX-2)] expression in human gingival fibroblasts . Positive_regulation PTGS2 IL1B 10942208 721301 These results suggest that NFkappaB is an important transcription factor for *induced* [COX-2] gene expression , and is involved in inducing COX-2 gene transcription through tyrosine phosphorylation in HGF . Positive_regulation PTGS2 IL1B 10960082 726351 *Induction* of [COX-2] and PGE ( 2 ) biosynthesis by is mediated by PKC and mitogen activated protein kinases in murine astrocytes . Positive_regulation PTGS2 IL1B 10960082 726352 This occurred early at 2 h , with a maximum at 4 h and declined at 12 h . treatment also *induced* the expression of [COX-2] protein as determined by immunoblot analysis . Positive_regulation PTGS2 IL1B 10999850 734384 Cultured myometrial cells expressed low levels of Cox-2 mRNA under baseline conditions , but *caused* a 17-fold induction of expression of the [Cox-2] transcript after incubation for 6 h . IL-1beta also induced expression of biologically active Cox-2 protein , as detected by immunofluorescence , Western blot analysis , and measuring the conversion of arachidonic acid to prostanoids in the presence and absence of a Cox-2-selective inhibitor , NS-398 . Positive_regulation PTGS2 IL1B 11032891 740419 *induces* [cyclooxygenase-2] and prostaglandin E ( 2 ) synthesis in human neuroblastoma cells : involvement of p38 mitogen activated protein kinase and nuclear factor-kappaB . Positive_regulation PTGS2 IL1B 11032891 740421 We further demonstrate that both a free radical scavenger and an inhibitor of p38 mitogen activated protein kinase (MAPK) reduce *induced* synthesis of [COX-2] . Positive_regulation PTGS2 IL1B 11032891 740462 Our data suggest that *induced* [COX-2] expression in SK-N-SH cells is regulated by different mechanisms , presumably involving mRNA transcription and mRNA stability . Positive_regulation PTGS2 IL1B 11053030 745141 The p38 inhibitor SB-203580 ( 3 microM ) decreased *induced* [COX-2] by 70 +/- 7 % ( P < 0.01 ) . Positive_regulation PTGS2 IL1B 11053030 745142 The NF-kappa B inhibitor MG-132 did not alter *induced* [COX-2] expression , indicating that NF-kappa B activation is not required for IL-1 beta induced COX-2 expression in HASM cells . Positive_regulation PTGS2 IL1B 11053030 745146 These results are consistent with the hypothesis that p38 is involved in the signal transduction pathway through which *induces* [COX-2] expression , PGE ( 2 ) release , and beta-adrenergic hyporesponsiveness . Positive_regulation PTGS2 IL1B 11062012 746435 However , as ERK is not required for *dependent* induction of [COX-2] , the mechanism of ceramide and SMase induction of COX-2 remains unclear . Positive_regulation PTGS2 IL1B 11079466 749552 According to Western blot and reverse transcription-polymerase chain reaction ( RT-PCR ) test results , NAC inhibited *induced* [COX-2] expression in protein and messenger RNA . Positive_regulation PTGS2 IL1B 11082190 750247 Critical role of C/EBPdelta and C/EBPbeta factors in the *stimulation* of the [cyclooxygenase-2] gene transcription by in articular chondrocytes . Positive_regulation PTGS2 IL1B 11082190 750255 The p50/p50 homodimer could interact with the C/EBP family members bound to the [ -132 ; -124 ] sequence for full *stimulation* of the [COX-2] transcription by in chondrocytes . Positive_regulation PTGS2 IL1B 11108281 756834 After 4 h of stimulation , *induced* gene expression of [cyclooxygenase-2 (COX-2)] but not cyclooxygenase-1 (COX-1) . Positive_regulation PTGS2 IL1B 11112151 757527 Effect of endogenous and exogenous prostaglandin E ( 2 ) on *induced* [cyclooxygenase-2] expression in human airway smooth-muscle cells . Positive_regulation PTGS2 IL1B 11112151 757528 We studied the effect of endogenous and exogenous prostaglandin E ( 2 ) ( PGE ( 2 ) ) , a metabolite of arachidonic acid through the cyclooxygenase (COX) pathway , on *induced* [COX-2] expression , using primary cultures of human bronchial smooth-muscle cells ( HBSMC ) . Positive_regulation PTGS2 IL1B 11112151 757529 Treatment with exogenous PGE ( 2 ) resulted in enhanced expression of IL-1 beta induced COX-2 protein and messenger RNA ( mRNA ) as compared with the effect of the cytokine per se. Inhibition of PGE ( 2 ) production with a nonselective COX inhibitor ( flurbiprofen , 10 microM ) resulted in a significant reduction in *induced* [COX-2] expression , supporting a role of endogenous COX metabolites in the modulation of COX-2 expression . Positive_regulation PTGS2 IL1B 11112151 757530 PGE ( 2 ) increased adenylate cyclase activity in a concentration dependent manner , and forskolin , a direct activator of adenylate cyclase , caused a marked increase in *dependent* [COX-2] , suggesting the existence of a causal relationship between the two events . Positive_regulation PTGS2 IL1B 11132768 760228 COX activity and [COX2] expression were significantly *increased* by . Positive_regulation PTGS2 IL1B 11171589 783926 The *induction* of [PGHS-2] and PGE ( 2 ) synthesis by could be blocked by glucocorticoid treatment . Positive_regulation PTGS2 IL1B 11250126 793699 *induced* [cyclooxygenase 2] expression and prostaglandin E2 secretion by human neuroblastoma cells : implications for Alzheimer 's disease . Positive_regulation PTGS2 IL1B 11260714 796242 *mediated* induction of [Cox-2] in the CNS contributes to inflammatory pain hypersensitivity . Positive_regulation PTGS2 IL1B 11260714 796244 Thus , preventing central prostanoid production by inhibiting the mediated *induction* of [Cox-2] in neurons or by inhibiting central Cox-2 activity reduces centrally generated inflammatory pain hypersensitivity . Positive_regulation PTGS2 IL1B 11278846 819379 This study demonstrates that sodium salicylate at a therapeutic concentration suppressed [COX-2] gene transcription *induced* by phorbol 12-myristate 13-acetate and by inhibiting the binding of CCAAT/enhancer binding protein beta to its promoter region of COX-2 . Positive_regulation PTGS2 IL1B 11286988 799902 In monolayers , *induced* [COX-2] and NOS II expression in a dose- and time dependent manner , to produce high prostaglandin E ( 2 ) ( PGE ( 2 ) ) and nitrite ( NO ( 2 ) ( - ) ) levels in an apparently coordinated fashion . Positive_regulation PTGS2 IL1B 11286988 799906 These results show that in chondrocytes : ( i ) [COX2] and NOS II genes are *induced* sequentially and distinctly by ; Positive_regulation PTGS2 IL1B 11296546 801509 Differential regulation of *induced* [cyclooxygenase-2] gene expression by nimesulide in human synovial fibroblasts . Positive_regulation PTGS2 IL1B 11296546 801510 Nimesulide or NS-398 inhibited IL-1 beta induced PGE2 production at all concentrations tested , and in addition they suppressed *induced* [COX-2] mRNA expression and protein synthesis . Positive_regulation PTGS2 IL1B 11350802 814711 In other cell types , IL-6 family cytokines induce [COX-2] or augment *induced* COX-2 expression . Positive_regulation PTGS2 IL1B 11350802 814715 In contrast , IL-6 and IL-11 did not alter *induced* [COX-2] expression . Positive_regulation PTGS2 IL1B 11350802 814716 In addition , OSM and synergistically *cause* [COX-2] expression and PGE ( 2 ) release . Positive_regulation PTGS2 IL1B 11352510 814835 Dexamethasone and actinomycin D completely suppressed not only the *induced* [cyclooxygenase-2] mRNA expression , but also the bradykinin induced cyclooxygenase-2 mRNA expression in the interleukin-1 beta primed fibroblasts , although cycloheximide did not inhibit the effects of interleukin-1 beta and bradykinin . Positive_regulation PTGS2 IL1B 11399097 823939 Nimesulide reduces *induced* [cyclooxygenase-2] gene expression in human synovial fibroblasts . Positive_regulation PTGS2 IL1B 11399097 823940 NIM inhibited *induced* [COX-2] expression and protein at sub and therapeutic concentrations ( 0.03-0.3 microg/ml ) while the non-specific NSAID , naproxen , did not . Positive_regulation PTGS2 IL1B 11399097 823944 Pre-treatment of cells with O ( 2 ) radical scavengers ( e.g. PDTC ) or with Ca ( ++ ) channel blockers ( e.g. verapamil ) had a modest effect on *induced* [COX-2] expression . Positive_regulation PTGS2 IL1B 11407686 825872 Anti-MIF mAb significantly reduced *induced* COX activity ( P < 0.05 ) and [COX-2] mRNA expression . Positive_regulation PTGS2 IL1B 11423555 843274 The eicosanoid did n't potentiate *induced* [COX-2] expression nor did it activate COX-2 gene expression in quiescent cells . Positive_regulation PTGS2 IL1B 11432874 850316 These results suggest that [COX-2] *induced* by PMA and is colocalized with caveolin-1 in the segregated caveolae compartment . Positive_regulation PTGS2 IL1B 11457450 838168 15-deoxy-Delta12,14-prostaglandin J2 ( 15d-PGJ2 ) , in contrast to troglitazone , was highly potent to counteract *induced* [cyclooxygenase-2] and inductible nitric oxide synthase expression , NO production and the decrease in proteoglycan synthesis . Positive_regulation PTGS2 IL1B 11509550 848342 and TNF-alpha in combination also significantly *enhanced* [COX-2] promoter activity , indicating that synergism between the cytokines is mediated at the level of gene transcription . Positive_regulation PTGS2 IL1B 11509629 848621 TXA ( 2 ) was the predominant COX-1 derived product , and TXA ( 2 ) synthesis changed little with *up-regulation* of [COX-2] by ( 2-fold increase ) . Positive_regulation PTGS2 IL1B 11509629 848622 The *up-regulation* of [COX-2] by was accompanied by specific up-regulation of PGI synthase and PGE synthase , but not TX synthase . Positive_regulation PTGS2 IL1B 11527948 853463 Pretreatment of RPE cells with a NF-kappa B inhibitor , PDTC , resulted in dose dependent decrease in *induced* [COX-2] gene expression and PG production . Positive_regulation PTGS2 IL1B 11530235 853782 *induced* both nitric oxide synthase 2 (NOS-2) and [cyclooxygenase 2 (COX-2)] gene expression in dorsal root ganglion explant culture with increased NOS-2 and COX-2 activities , and corresponding increases in the production of nitric oxide and prostaglandin E ( 2 ) . Positive_regulation PTGS2 IL1B 11530235 853784 The signaling mechanisms by which *regulates* NOS-2 and [COX-2] genes remain obscure . Positive_regulation PTGS2 IL1B 11530235 853788 In contrast , pyrrolidine dithiocarbamate significantly inhibited COX-2 gene expression at the posttranscriptional level , since pyrrolidine dithiocarbamate did not affect *induced* [COX-2] mRNA transcripts but inhibited COX-2 protein expression and prostaglandin E ( 2 ) production . Positive_regulation PTGS2 IL1B 11530235 853790 Rotenone , another antioxidant that attenuates reactive oxygen species production by inhibiting the mitochondrial electron transport system , failed to inhibit *induced* NOS-2 and [COX-2] mRNA encoding transcripts . Positive_regulation PTGS2 IL1B 11530235 853796 These results indicate that not only transcriptional regulation , but also posttranscriptional events are involved in a redox-sensitive regulation of *induced* NOS-2 and [COX-2] gene expression in the dorsal root ganglia . Positive_regulation PTGS2 IL1B 11686835 875879 *induces* [cyclo-oxygenase-2] expression in gastric cancer cells by the p38 and p44/42 mitogen activated protein kinase signaling pathways . Positive_regulation PTGS2 IL1B 11686835 875883 Our results demonstrated that in human gastric cancer cells , *upregulates* the [COX-2] gene expression through the activation of MEK/p44/42 and p38 MAP kinases pathway . Positive_regulation PTGS2 IL1B 11700032 878455 In human primary cultured decidual cells , a p38 inhibitor , SB202190 , significantly inhibited both prostaglandin F ( 2alpha ) production and [COX-2] expression *induced* by stimulation with . Positive_regulation PTGS2 IL1B 11847219 936778 These results indicate that the *induction* of [PGHS-2] and mPGES by underlies robust PGE ( 2 ) production in orbital fibroblasts . Positive_regulation PTGS2 IL1B 11853544 913349 Differentiation regulates *induced* [cyclo-oxygenase-2] in human articular chondrocytes : role of p38 mitogen activated protein kinase . Positive_regulation PTGS2 IL1B 11853544 913351 Moreover , *induced* [COX-2] expression at 0.01 ng/ml in ( alg+ ) cells , whereas a 100-fold higher dose of cytokine was necessary for stimulation in ( alg- ) cells . Positive_regulation PTGS2 IL1B 11854442 913934 Pretreating the cells with 1-butanol and Ro 31-8220 inhibited the *induced* [COX-2] expression , but 3-butanol did not affect this response . Positive_regulation PTGS2 IL1B 11854442 913952 Moreover , IL-1 beta stimulation of the cells caused the phosphorylation of p38 and extracellular signal regulated kinase ( ERK ) , and *induced* [COX-2] expression was inhibited by the pretreatment of WISH cells with a p38 inhibitor , in contrast ERK upstream inhibitor had no effect . Positive_regulation PTGS2 IL1B 11854442 913972 The results of this study indicate that in human amnion cells , might activate PLD through an upstream protein kinase C to elicit p38 and finally *induce* [COX-2] expression . Positive_regulation PTGS2 IL1B 11934644 927810 This is evidenced by the fact that TENS at low magnitude : ( i ) inhibits recombinant human ( rh ) *dependent* induction of [cyclooxygenase-2 (COX-2)] mRNA expression and production of prostaglandin estradiol ( PGE2 ) ; Positive_regulation PTGS2 IL1B 11971025 933512 We found that PPAR alpha ligands ( clofibrate and WY14643 ) enhanced *induced* [COX-2] expression in human astrocytes and microglia , while inhibiting IL-1 beta plus IFN-gamma induction of iNOS in astrocytes . Positive_regulation PTGS2 IL1B 12021045 942769 These results suggest that NFkappaB is involved in the *induced* [COX-2] expression in the mesenchymal cells of human amnion . Positive_regulation PTGS2 IL1B 12028436 947481 15-Deoxy-Delta12,14-prostaglandin J2 inhibits *induced* [cyclooxygenase-2] expression in mesangial cells . Positive_regulation PTGS2 IL1B 12028436 947484 15D-PGJ2 significantly suppressed *induced* [COX-2] expression and PGE2 production , but thiazolidinediones , synthetic PPARgamma ligands , did not affect COX-2 expression . Positive_regulation PTGS2 IL1B 12028436 947486 These data suggest that 15d-PGJ2 inhibits *induced* [COX-2] expression , independent of PPARgamma activation , by suppression of ERK and JNK pathways and AP-1 activation in mesangial cells . Positive_regulation PTGS2 IL1B 12031964 947860 Inhibition of *induced* [COX-2] and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function . Positive_regulation PTGS2 IL1B 12050157 968749 Together , and amyloid beta42 peptide [ IL-1beta+Abeta42 ] synergistically *activated* [COX-2] and PS1 gene expression preceded by increases in AP1- , STAT1alpha- , and in particular NF-kappaBp50/p65- and HIF-1alpha-DNA binding . Positive_regulation PTGS2 IL1B 12060668 968859 This factor , which was named cytoguardin , suppressed [COX-2] protein levels *induced* by phorbol 12-myristate 13-acetate , , tumor necrosis factor alpha , and lipopolysaccharide (LPS) in fibroblasts and LPS induced COX-2 protein levels and promoter activities in human endothelial cells and murine RAW 264.7 cells in a comparable concentration dependent manner . Positive_regulation PTGS2 IL1B 12107235 963032 COX-2 mRNA , protein , and PGE ( 2 ) levels in IL-1beta treated ESC were decreased by a PKA inhibitor , a nuclear factor ( NF-kappaB ) inhibitor , and an ERK1/2 inhibitor , but not by a p38 MAPK inhibitor or a PKC inhibitor , suggesting the possible involvement of PKA , NF-kappaB , and/or the ERK1/2 signaling pathway ( s ) in *mediated* [COX-2] gene induction in ESC . Positive_regulation PTGS2 IL1B 12107235 963034 We found that 1 ) significantly *increased* [COX-2] mRNA stability ; Positive_regulation PTGS2 IL1B 12113880 963884 Interferon gamma antagonizes *induced* [cyclooxygenase-2] expression and prostaglandin E ( 2 ) production in human myometrial cells . Positive_regulation PTGS2 IL1B 12124863 965848 *induced* robust expression of [COX-2] and PGE ( 2 ) in OA meniscus , synovial membrane , and osteophytic fibrocartilage explants , whereas low levels were produced in OA articular cartilage . Positive_regulation PTGS2 IL1B 12124863 965855 *induced* production of [COX-2] protein and PGE ( 2 ) was low in OA articular cartilage compared with that in the other OA tissues examined . Positive_regulation PTGS2 IL1B 12145100 969673 TNF-alpha , inefficient by itself , potentiates *induced* [PGHS-2] expression in human pulmonary microvascular endothelial cells : requirement of NF-kappaB and p38 MAPK pathways . Positive_regulation PTGS2 IL1B 12147254 970009 *increased* expression of [COX-2] and induced accumulation and nuclear translocation of transcriptionally competent beta-catenin . Positive_regulation PTGS2 IL1B 12193539 981334 Although COX1 is the constitutive isoform of COX , is a potent *inducer* of [COX2] expression in distinct cell types . Positive_regulation PTGS2 IL1B 12220616 986964 *induced* [cyclooxygenase-2] expression is mediated through activation of p42/44 and p38 MAPKS , and NF-kappaB pathways in canine tracheal smooth muscle cells . Positive_regulation PTGS2 IL1B 12220616 986965 markedly *increased* [COX-2] expression and PGE ( 2 ) formation in a time- and concentration dependent manner in TSMCs . Positive_regulation PTGS2 IL1B 12225948 987912 Bradykinin , transforming growth factor-beta1 ( TGF-beta1 ) , and *increased* inducible [COX-2] expression and prostaglandin E ( 2 ) ( PGE ( 2 ) ) release . Positive_regulation PTGS2 IL1B 12237848 989219 These studies demonstrated that , TNFalpha , IL-6 , but not IFN-gamma *increase* the expression of [Cox-2] , whereas they all increase the expression of HCK and FAK . Positive_regulation PTGS2 IL1B 12356282 993766 We examined the inhibitory mechanism of byakangelicol , isolated from Angelica dahurica , on *induced* [cyclooxygenase-2 (COX-2)] expression and prostaglandin E2 ( PGE2 ) release in human pulmonary epithelial cell line ( A549 ) . Positive_regulation PTGS2 IL1B 12356282 993767 Byakangelicol ( 10-50 microM ) concentration-dependently attenuated *induced* [COX-2] expression and PGE2 release . Positive_regulation PTGS2 IL1B 12356282 993917 The inhibitory mechanism of byakangelicol on *induced* [COX-2] expression may be , at least in part , through suppression of NF-kappaB activity . Positive_regulation PTGS2 IL1B 12374621 996602 Green tea polyphenol epigallocatechin-3-gallate inhibits the *induced* activity and expression of [cyclooxygenase-2] and nitric oxide synthase-2 in human chondrocytes . Positive_regulation PTGS2 IL1B 12374621 996605 In the present study , we report the pharmacological effects of green tea polyphenol epigallocatechin-3-gallate ( EGCG ) , on *induced* expression and activity of [cyclooxygenase-2 (COX-2)] and inducible nitric oxide synthase (iNOS) in human chondrocytes derived from osteoarthritis ( OA ) cartilage . Positive_regulation PTGS2 IL1B 12374621 996607 In addition , *induced* expression of iNOS and [COX-2] was also markedly inhibited in human chondrocytes pretreated with EGCG ( p < .001 ) . Positive_regulation PTGS2 IL1B 12384172 998587 Nitric oxide synergistically potentiates *induced* increase of [cyclooxygenase-2] mRNA levels , resulting in the facilitation of substance P release from primary afferent neurons : involvement of cGMP independent mechanisms . Positive_regulation PTGS2 IL1B 12384172 998589 These results suggest that in cultured DRG cells , NO potentiates the *induced* increase in [COX-2] expression via a soluble guanylate cyclase-cGMP independent pathway , resulting in facilitation of SP release . Positive_regulation PTGS2 IL1B 12391274 1007534 The inhibition of both MAPKs reduced *induced* [COX-2] expression and PGE ( 2 ) synthesis . Positive_regulation PTGS2 IL1B 12417253 1012943 Effects of sphondin , isolated from Heracleum laciniatum , on *induced* [cyclooxygenase-2] expression in human pulmonary epithelial cells . Positive_regulation PTGS2 IL1B 12417253 1012944 Recently , under large-scale screening experiments , we found that sphondin , a furanocoumarin derivative isolated from Heracleum laciniatum , possessed an inhibitory effect on *induced* increase in the level of [COX-2] protein and PGE ( 2 ) release in A549 cells . Positive_regulation PTGS2 IL1B 12417253 1012945 Accordingly , we examined in the present study the action mechanism of sphondin on the inhibition of *induced* [COX-2] protein expression and PGE ( 2 ) release in a human pulmonary epithelial cell line ( A549 ) . Positive_regulation PTGS2 IL1B 12417253 1012946 Pretreatment of cells with sphondin ( 10-50 microM ) concentration-dependently attenuated *induced* [COX-2] protein expression and PGE ( 2 ) release . Positive_regulation PTGS2 IL1B 12417253 1012947 The *induced* increase in [COX-2] mRNA expression was also attenuated by sphondin ( 50 microM ) . Positive_regulation PTGS2 IL1B 12417253 1012966 The inhibitory mechanism of sphondin on *induced* [COX-2] expression may be , at least in part , through suppression of NF-kappaB activity . Positive_regulation PTGS2 IL1B 12435328 1015842 Data showed that , as expected , *induced* both [COX-2] and PGE ( 2 ) production . Positive_regulation PTGS2 IL1B 12446609 1017809 In contrast , exogenous corticosterone abolished the effects of ketorolac on *induced* [COX-2] and monocyte chemoattractant protein-1 gene expression in the cerebral endothelium . Positive_regulation PTGS2 IL1B 12453435 1020772 The oxygen radical scavenger pyrrolidine dithiocarbamate enhances *induced* [cyclooxygenase-2] expression in cerebral microvascular smooth muscle cells . Positive_regulation PTGS2 IL1B 12453435 1020773 *increased* [COX-2] protein expression in a dose- and time dependent manner , an increase that was further enhanced by PDTC in a dose dependent manner . Positive_regulation PTGS2 IL1B 12453435 1020774 These results suggest that endogenous oxygen radicals may blunt [COX-2] *induced* by through an effect on translation . Positive_regulation PTGS2 IL1B 12511556 1063601 Furthermore , [COX-2] expression , *induced* by the vasoconstrictor peptide ET-1 or the cytokine also inhibited TNFalpha mediated but not etoposide mediated apoptosis , to an extent , similar to adenoviral COX-2 infection . Positive_regulation PTGS2 IL1B 12512699 1027686 Here we demonstrated that is an *inducer* of [COX-2] and PGE-S in human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation PTGS2 IL1B 12517972 1039410 We show in this study that indomethacin (Indo) , flurbiprofen ( Flur ) , and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced *induced* [COX-2] expression in human airway smooth muscle ( HASM ) cells . Positive_regulation PTGS2 IL1B 12517972 1039411 Indeed , PGE ( 2 ) also induced and enhanced *induced* [COX-2] expression . Positive_regulation PTGS2 IL1B 12529415 1048783 ( 1 ng/ml ) *induced* the expression of [cyclooxygenase-2 (COX-2)] protein 6 h after treatment , accompanied by a 7.5-fold increase in PGE ( 2 ) production . Positive_regulation PTGS2 IL1B 12568957 1057195 *induces* [COX2] , MMP-1 , -3 and -13 , ADAMTS-4 , IL-1 beta and IL-6 in human tendon cells . Positive_regulation PTGS2 IL1B 12573452 1057529 Inhibition by eicosapentaenoic acid of *induced* [PGHS-2] expression in human microvascular endothelial cells : involvement of lipoxygenase derived metabolites and p38 MAPK pathway . Positive_regulation PTGS2 IL1B 12573452 1057530 We established that among fish oil polyunsaturated fatty acids ( PUFAs ) , eicosapentaenoic acid ( EPA ) , but not docosahexaenoic acid ( DHA ) , greatly decreased *induced* [PGHS-2] expression in human pulmonary microvascular endothelial cells ( HPMECs ) . Positive_regulation PTGS2 IL1B 12573452 1057531 Moreover , cyclooxygenase metabolites of EPA ( PGs D3 , E3 and I3 ) markedly potentiate *induced* [PGHS-2] expression , probably by increasing intracellular cAMP levels . Positive_regulation PTGS2 IL1B 12573452 1057532 We found here that HPMECs express only weak amounts of PPARalpha and PPARgamma whose activation by synthetic agonists , Wy-14,643 and ciglitazone , does not cause any inhibition of *induced* [PGHS-2] expression . Positive_regulation PTGS2 IL1B 12588703 1084946 IL-9 had no effect on cyclooxygenase-2 (COX-2) expression or PGE ( 2 ) release and did not augment the [COX-2] expression that was *induced* by . Positive_regulation PTGS2 IL1B 12649265 1080019 induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and *stimulated* RNA polymerase II binding to the [COX-2] promoter , COX-2 transcription , COX-2 protein synthesis , and prostaglandin E2 ( PGE2 ) release . Positive_regulation PTGS2 IL1B 12649265 1080075 Infecting cardiomyocytes with adenoviruses that encode mutant , phosphorylation-resistant MKK6 or p38beta2 MAPK inhibited *induced* p38 MAPK activation , [COX-2] gene expression , and PGE2 release . Positive_regulation PTGS2 IL1B 12649265 1080076 Treatment with the p38alpha and p38beta2 MAPK inhibitor , SB202190 , attenuated *induced* [COX-2] transcription and accelerated the degradation of COX-2 mRNA . Positive_regulation PTGS2 IL1B 12649265 1080090 These results provide direct evidence that MKK6 mediated p38 MAPK activation is necessary for *induced* cardiac myocyte [COX-2] gene expression and PGE2 biosynthesis in vitro and is sufficient for COX-2 gene expression by cardiac myocytes in vitro and in vivo . Positive_regulation PTGS2 IL1B 12672669 1099641 In LSF cells , significantly *increased* IL-8 and PGE2 synthesis and [COX-2] and IL-8 mRNA expression , but progesterone significantly attenuated these effects . Positive_regulation PTGS2 IL1B 12672669 1099643 In prelabor amnion cells , also *increased* IL-8 and PGE2 synthesis and both [COX-2] and IL-8 mRNA and promoter expression ; Positive_regulation PTGS2 IL1B 12672669 1099646 In postlabor amnion cells , *increased* IL-8 and PGE2 synthesis and [COX-2] expression , but progesterone did not attenuate the effect of IL-1beta upon IL-8 synthesis . Positive_regulation PTGS2 IL1B 12681956 1077503 GS also inhibited the gene expression and the protein synthesis of [COX-2] *induced* by , while no effect on COX-1 synthesis was seen . Positive_regulation PTGS2 IL1B 12755375 1090498 LPS and *stimulated* IL-1beta , IL-6 , IL-8 , iNOS and [COX-2] gene expression . Positive_regulation PTGS2 IL1B 12839952 1108181 [Cyclooxygenase-2] is *up-regulated* by in human colorectal cancer cells via multiple signaling pathways . Positive_regulation PTGS2 IL1B 12839952 1108189 These data demonstrate that *induces* [COX-2] expression in HT-29 cells through multiple signaling pathways and NF-kappa B . Positive_regulation PTGS2 IL1B 12881220 1157236 [COX-2] was significantly *induced* by VEGF ( 4.86 +/- 1.03-fold ) and ( 3.93 +/- 0.89-fold ) and slightly increased by TNF-alpha but not by FGF2 , IGF-1 , or PDGFs . Positive_regulation PTGS2 IL1B 12885795 1142853 To determine the role of 15dPGJ2 in expression of proinflammatory genes , we tested its effect on *induction* of [cyclooxygenase-2 (COX-2)] . Positive_regulation PTGS2 IL1B 12892443 1117790 The results showed that lipopolysaccharide and tumor necrosis factor alpha , or TNF-alpha , *induced* [COX-2] in macrophages , while and TNF-alpha induced COX-2 in oral epithelial cells . Positive_regulation PTGS2 IL1B 12923200 1151284 In addition , in neural cells in culture , this lipid messenger also inhibited both *induced* NFkappaB activation and [cyclooxygenase-2] expression . Positive_regulation PTGS2 IL1B 14645533 1173020 Bradykinin and *induce* [cyclooxygenase 2 (COX-2)] in human airway smooth muscle cells . Positive_regulation PTGS2 IL1B 14645533 1173023 We also revealed that endogenous prostaglandin E ( 2 ) was critical in bradykinin induced COX-2 transcription initiation and involved in *induced* [COX-2] transcription at a latter stage . Positive_regulation PTGS2 IL1B 14671209 1178367 In VT cells in culture , *up-regulated* [COX-2] protein expression but did not affect mPGES . Positive_regulation PTGS2 IL1B 14671209 1178370 In CT cells in culture , and TNF-alpha *increased* both mPGES and [COX-2] protein levels . Positive_regulation PTGS2 IL1B 14989826 1215341 [ Hydrogen peroxide upregulates *induced* [cyclooxygenase-2] expression in human pulmonary epithelial cells ] . Positive_regulation PTGS2 IL1B 14989826 1215342 To investigate the effect of hydrogen peroxide ( H ( 2 ) O ( 2 ) ) on *induced* [cyclooxygenase-2 (COX-2)] expression in human pulmonary epithelial cells ( HPEC ) . Positive_regulation PTGS2 IL1B 14989826 1215343 Hydrogen peroxide upregulates *induced* [COX-2] expression in HPEC at transcriptional level . Positive_regulation PTGS2 IL1B 14996278 1216221 also *induced* [COX-2] expression in gingival fibroblasts , and PGE2 , a major COX-2 product , was found to enhance MMP-1 expression . Positive_regulation PTGS2 IL1B 15016613 1257076 Western blot analysis of mucosal homogenates revealed dramatic upregulation of [COX-2] in *response* to or peritoneal PMNs , and the latter was inhibited by an IL-1beta receptor antagonist . Positive_regulation PTGS2 IL1B 15016613 1257078 Real-time PCR revealed that increased mRNA COX-2 expression preceded increased [COX-2] protein expression in *response* to . Positive_regulation PTGS2 IL1B 15016613 1257080 We concluded that PMNs augment recovery of TER in ischemia injured ileal mucosa via *dependent* upregulation of [COX-2] . Positive_regulation PTGS2 IL1B 15024756 1222437 However , despite the fact that *induces* the prostaglandin synthesizing enzyme [cyclooxygenase-2 (COX-2)] in brain vascular cells , no study has established the presence of IL-1 receptor type 1 (IL-1R1) protein in these cells . Positive_regulation PTGS2 IL1B 15067222 1231889 *Induction* of [cyclooxygenase-2] expression in human tracheal smooth muscle cells by : involvement of p42/p44 and p38 mitogen activated protein kinases and nuclear factor-kappaB . Positive_regulation PTGS2 IL1B 15067222 1231891 We found that *increased* [COX-2] expression and PGE ( 2 ) synthesis in time- and concentration dependent manners . Positive_regulation PTGS2 IL1B 15067222 1231905 *induced* [COX-2] expression and PGE ( 2 ) synthesis were also inhibited by an inhibitor of MEK1/2 ( PD98059 ) and inhibitors of p38 MAPK ( SB203580 and SB202190 ) , respectively , suggesting the involvement of p42/p44 and p38 MAPKs in these responses . Positive_regulation PTGS2 IL1B 15111866 1241248 We further demonstrated that p38 MAPK is activated by and PDGF with different kinetics and that p38 MAPK is *required* for maximal [COX2] expression in response to IL-1beta plus PDGF-BB . Positive_regulation PTGS2 IL1B 15124245 1242465 Both and TNF-a upregulated COX-2 mRNA comparably to IL-15 , but neither IL-2 nor interferon-g *had* any effect on the [COX-2] mRNA level . Positive_regulation PTGS2 IL1B 15152078 1252529 NPD1 also inhibited *stimulated* expression of [cyclooxygenase 2] promoter transfected into ARPE-19 cells . Positive_regulation PTGS2 IL1B 15217394 1263754 In view of the fact that is the major *inducer* of spinal [COX-2] upregulation following CFA injection , our results suggest that IL-1 beta induced spinal COX-2 upregulation and pain hypersensitivity following peripheral inflammation are mediated through the activation of the NF-kB associated pathways . Positive_regulation PTGS2 IL1B 15266025 1275901 We found that *increased* [cyclooxygenase-2 (COX-2)] mRNA expression and prostaglandin ( PG ) E ( 2 ) production and that the COX-2 inhibitor celecoxib suppressed IL-1beta induced MUC5AC production . Positive_regulation PTGS2 IL1B 15313472 1285549 and IL-6 and , to a lesser extent , TNF-alpha , *enhances* [COX-2] mRNA levels in calvarial osteoblasts . Positive_regulation PTGS2 IL1B 15313472 1285551 In contrast , the presence of TGF-beta reduced [COX-2] mRNA level , PGE ( 2 ) biosynthesis and bone resorption *induced* by , TNF-alpha , IL-6 or a combination thereof . Positive_regulation PTGS2 IL1B 15334456 1291068 In hypoxia , transcription of [cyclooxygenase 2 (COX-2)] , expression of COX-2 protein , and production of COX-2 derived eicosanoids and matrix metalloproteinase (MMP) activity by FLS were all increased in *response* to . Positive_regulation PTGS2 IL1B 15361371 1293701 *increased* [COX-2] and did not alter COX-1 synthesis in SF. 11-Deoxy-PGE ( 1 ) , an EP(2)/EP(4) agonist , reproduced PGE ( 2 ) action on MCP-1 expression . Positive_regulation PTGS2 IL1B 15457451 1301463 The specific p38alpha MAPK inhibitor SC906 suppressed *induced* [COX-2] expression but not IL-1beta induced mPGES-1 expression , suggesting preferential involvement of p38beta MAPK in IL-1beta induced mPGES-1 expression . Positive_regulation PTGS2 IL1B 15479233 1319773 Conversely , whereas dexamethasone and budesonide were highly effective inhibitors of *induced* cyclooxygenase (COX)/prostaglandin E synthase (PGES) activity and [COX-2] expression , RU486 ( < 1 microm ) was a poor inhibitor , but was able to efficiently antagonize the effects of dexamethasone and budesonide . Positive_regulation PTGS2 IL1B 15483103 1359296 *Induction* of [COX-2] expression in normal endometrial stroma by is primary due to enhancement of COX-2 mRNA stability . Positive_regulation PTGS2 IL1B 15483103 1359297 In contrast , not only *increases* [COX-2] mRNA stability but also up-regulates COX-2 promoter activity in ectopic endometriotic stroma . Positive_regulation PTGS2 IL1B 15483103 1359298 *Induction* of [COX-2] promoter activity by is mediated via MAPK dependent phosphorylation of cAMP responding element binding protein . Positive_regulation PTGS2 IL1B 15483103 1359299 Promoter activity and EMSAs demonstrate that a cAMP response element site located at -571/-564 of COX-2 promoter is critical for *induced* [COX-2] gene expression . Positive_regulation PTGS2 IL1B 15550066 1338539 Effects of PD98059 , SB202190 and SP600125 ( inhibitors of ERK , p38 and JNK , respectively ) on *induced* secretion of IL-6 and IL-8 , and on IL-1beta induced expression of [cyclo-oxygenase-2 (COX-2)] in endometriotic cells were studied . Positive_regulation PTGS2 IL1B 15550066 1338543 Both SB202190 and PD98059 suppressed *induced* expression of [COX-2] in endometriotic cells . Positive_regulation PTGS2 IL1B 15621371 1358427 Tumor necrosis factor alpha and *stimulate* the expression of [cyclooxygenase II] but do not alter prostaglandin E2 receptor mRNA levels in cultured dorsal root ganglia cells . Positive_regulation PTGS2 IL1B 15621371 1358432 These results indicate that TNFalpha and *induce* the functional expression of [COX-2] but not EP receptors in DRG cells in culture and suggest that cytokine induced sensitization of sensory neurons is secondary to prostaglandin production and not alterations in EP receptors . Positive_regulation PTGS2 IL1B 15641079 1362998 Inhibition of *induced* [cyclooxygenase 2] expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase independent mechanism . Positive_regulation PTGS2 IL1B 15641079 1362999 We undertook this study to investigate the effects of 15d-PGJ ( 2 ) on *induced* [COX-2] expression in human synovial fibroblasts ( HSFs ) . Positive_regulation PTGS2 IL1B 15641079 1363000 *induced* COX-2 protein and mRNA expression , as well as [COX-2] promoter activation , were inhibited by 15d-PGJ ( 2 ) . Positive_regulation PTGS2 IL1B 15641079 1363001 These data suggest that 15d-PGJ ( 2 ) can inhibit *induced* [COX-2] expression by an HDAC independent mechanism , probably by interfering with HAT p300 . Positive_regulation PTGS2 IL1B 15723090 1396082 Similarly , IKK beta ( KA ) and I kappa B alpha delta N overexpression also inhibited IL-1beta- and TNF alpha dependent increases in ICAM-1 , IL-8 and GM-CSF in addition to *mediated* increases in [cyclooxygenase-2] expression , whereas IKK alpha ( KM ) overexpression had little effect on these outputs . Positive_regulation PTGS2 IL1B 15727891 1377057 In addition , *induced* [COX-2] expression by the cultured cells , as shown by Western blotting . Positive_regulation PTGS2 IL1B 15758944 1432209 *induces* [cyclooxygenase-2 (Cox-2)] expression in many of its cellular targets resulting in production and release of prostaglandins . Positive_regulation PTGS2 IL1B 15758944 1432210 Although *induced* [Cox-2] expression most likely requires activation of nuclear transcription factor kappa B ( NFkappaB ) pathway , this has never been formally demonstrated in vivo . Positive_regulation PTGS2 IL1B 15758944 1432214 Treatment with NBD peptide completely abolished *induced* NFkappaB activation and [Cox-2] synthesis in microvasculature . Positive_regulation PTGS2 IL1B 15784717 1410100 plays a key role in infection induced preterm labor and *increases* [prostaglandin H synthase 2 (PGHS-2)] and IL-8 expression . Positive_regulation PTGS2 IL1B 15784717 1410102 In this study , we tested the hypotheses that both and mechanical stretch *increase* the myometrial expression of [PGHS-2] and IL-8 via MAPK activation and that their effects are synergistic . Positive_regulation PTGS2 IL1B 15784717 1410103 The inhibitor studies showed that stretch induced increases in both PGHS-2 and IL-8 mRNA expression were ERK1/2 and p38 dependent and that *induced* increases of [PGHS-2] mRNA expression were also ERK1/2 and p38 dependent , but those of IL-8 were dependent only on ERK1/2 activation . Positive_regulation PTGS2 IL1B 15821150 1417631 At low concentrations ( < 0.1 microM ) , 15d-PGJ ( 2 ) inhibited *stimulated* prostaglandin E ( 2 ) ( PGE ( 2 ) ) but not cytokine ( IL-6/IL-8 ) production or [cyclooxygenase-2 (COX-2)] expression . Positive_regulation PTGS2 IL1B 15821150 1417632 At higher concentrations ( 1-10 microM ) , 15d-PGJ ( 2 ) inhibited *stimulated* PGE ( 2 ) and cytokine production and [COX-2] expression , and this effect was not blocked by GW9662 . Positive_regulation PTGS2 IL1B 15878911 1445414 *induced* [COX-2] expression in SEG-1 cells ( P < 0.05 ) , whereas IL-10 and IL-13 had no effect . Positive_regulation PTGS2 IL1B 15900319 1451778 To assess whether this action is mediated by NFkappaB activation , rats were injected into the lateral ventricle of the brain with a specific inhibitor of NFkappaB activation , the NEMO Binding Domain (NBD) peptide that has been shown previously to abolish completely *induced* NFkappaB activation and [Cox-2] synthesis in the brain microvasculature . Positive_regulation PTGS2 IL1B 15912889 1412561 NPD1 also inhibits *stimulated* expression of [COX-2] . Positive_regulation PTGS2 IL1B 15950779 1421567 *induced* cPLA2 and [COX-2] gene expression is modulated through the p38 MAPK pathway in both neuroglioma and neuroblastoma cells . Positive_regulation PTGS2 IL1B 15961395 1440747 c-Jun/activator protein-1 mediates *induced* dedifferentiation but not [cyclooxygenase-2] expression in articular chondrocytes . Positive_regulation PTGS2 IL1B 15961395 1440754 Interestingly , modulation of c-Jun expression did not affect *induced* [COX-2] expression . Positive_regulation PTGS2 IL1B 15961395 1440756 Further experiments revealed that c-Jun phosphorylation was mediated by c-Jun N-terminal kinase and was required for *induced* dedifferentiation but not [COX-2] expression . Positive_regulation PTGS2 IL1B 16081677 1466264 *induced* microsomal prostaglandin E synthase 1 ( mPGES-1 ) and [cyclooxygenase-2] were attenuated by curcumin at the protein and mRNA levels , but a more dramatic inhibition of mPGES-1 expression was observed at lower concentrations of curcumin in A549 human lung epithelial cells . Positive_regulation PTGS2 IL1B 16123052 1499102 [COX-2] in turn is *stimulated* by E ( 2 ) , and PGE ( 2 ) itself in endometrial and endometriotic cells . Positive_regulation PTGS2 IL1B 16210363 1501031 The mechanism involves blockade by IL-4 and interferon-gamma of the dependent *activation* of [PGHS-2] gene promoter activity . Positive_regulation PTGS2 IL1B 16277686 1480510 Real-time PCR analysis showed that *induced* [COX-2] expression maximally ( 37-fold ) at 12 hours and mPGES-1 expression maximally ( 68-fold ) at 24 hours . Positive_regulation PTGS2 IL1B 16326073 1553755 *Up-regulation* of [cyclooxygenase-2] by in colon carcinoma cells . Positive_regulation PTGS2 IL1B 16326073 1553814 Inhibition of NF-kappaB activation diminished *mediated* transcriptional activation of [COX-2] . Positive_regulation PTGS2 IL1B 16326073 1553819 p38 MAPK signalling was required for *dependent* stabilization of [COX-2] transcript . Positive_regulation PTGS2 IL1B 16428068 1515854 Moreover , NS-398 suppressed the anti-apoptotic activity of IL-8 and , but did not *induce* [COX-2] ; Positive_regulation PTGS2 IL1B 16452236 1522134 The cyclin dependent kinase 2 inhibitor down-regulates *mediated* induction of [cyclooxygenase-2] expression in human lung carcinoma cells . Positive_regulation PTGS2 IL1B 16452236 1522135 In this study , we furnish several lines of evidence that show a functional role for the CDK2 in *induced* [COX-2] expression in H358 human non-small cell lung carcinoma cell line by blocking CDK2 activity . Positive_regulation PTGS2 IL1B 16452236 1522136 First , we show that BMS-387032 , a potent CDK2 inhibitor , blocks *induced* expression as well as steady-state mRNA levels of [COX-2] . Positive_regulation PTGS2 IL1B 16452236 1522137 Second , we show that small interfering RNA that abrogates CDK2 expression also blocks *induced* [COX-2] expression . Positive_regulation PTGS2 IL1B 16452236 1522139 Moreover , CDK2 inhibition blocks *induced* binding to the NF-IL6 element of the [COX-2] promoter and inhibits transcription of the COX-2 gene . Positive_regulation PTGS2 IL1B 16452236 1522140 Taken together , the data suggest that CDK2 activity may play an important event in the *induced* [COX-2] expression and prostaglandin E ( 2 ) synthesis and might represent a novel target for BMS-387032 . Positive_regulation PTGS2 IL1B 16508938 1530316 We investigated the effects of S1P on proliferation by WST-1 assay , and its effects on tumor necrosis factor alpha (TNFalpha)- or *induced* [cyclooxygenase 2 (COX-2)] expression and prostaglandin E2 ( PGE2 ) production in RA synoviocytes and MH7A cells by Western blotting and enzyme linked immunosorbent assay , respectively . Positive_regulation PTGS2 IL1B 16513308 1574350 and IL-6 and to a lesser extent TNF-alpha , *enhanced* [COX-2] mRNA levels in calvarial osteoblasts . Positive_regulation PTGS2 IL1B 16574063 1550017 COX-2 mRNA was decreased in response to IL-4 , and promoter analysis indicated that IL-4 inhibited both constitutive and *induced* [COX-2] transcription . Positive_regulation PTGS2 IL1B 16624280 1556735 Cinnamaldehyde reduces *induced* [cyclooxygenase-2] activity in rat cerebral microvascular endothelial cells . Positive_regulation PTGS2 IL1B 16624280 1556736 *increased* the mRNA expression and activity of [COX-2] , and production of PGE ( 2 ) in a dose- and time dependent manner in RCMEC , while mRNA and activity of COX-1 were not significantly altered . Positive_regulation PTGS2 IL1B 16624280 1556737 Cinnamaldehyde significantly decreased *induced* [COX-2] activity and PGE ( 2 ) production in a dose dependent manner , while it showed no inhibitory effect on IL-1beta induced COX-2 mRNA expression in cultured RCMEC . Positive_regulation PTGS2 IL1B 16624280 1556738 In conclusion , cinnamaldehyde reduces *induced* [COX-2] activity , but not IL-1beta induced COX-2 mRNA expression , and consequently inhibits production of PGE ( 2 ) in cultured RCMEC . Positive_regulation PTGS2 IL1B 16632868 1631291 However , overexpression of 15-PGDH by transfection with recombinant plasmid encoding 15-PGDH or adenovirus mediated approach attenuated *induced* expression of [COX-2] . Positive_regulation PTGS2 IL1B 16632868 1631294 On the contrary , downregulation of 15-PGDH expression by 15-PGDH-siRNA or 15-PGDH-antisense approach resulted in an increase in *induced* expression of [COX-2] but not that of COX-1 . Positive_regulation PTGS2 IL1B 16632868 1631295 The levels of *induced* [COX-2] expression appeared to correlate inversely with those of 15-PGDH expression in the cells . Positive_regulation PTGS2 IL1B 16636611 1562981 Baicalin suppressed *induced* RANKL and [COX-2] production at a concentration of 0.01 microg/ml . Positive_regulation PTGS2 IL1B 16636611 1562982 The data suggest that baicalin may inhibit RANKL mRNA expression via the suppression of [COX-2] expression *induced* by . Positive_regulation PTGS2 IL1B 16948668 1610112 *stimulated* the [COX-2] but not COX-1 mRNA expression . Positive_regulation PTGS2 IL1B 17011110 1746983 After treatment with IL-1beta , IkappaB was degraded by almost 90 % within 5 min and became undetectable by 15 min . stimulation *increased* the levels of [COX-2] protein and the gelatinolytic activities of MMP-9 , both of which were inhibited by NF-kappaB inhibitors . Positive_regulation PTGS2 IL1B 17015748 1629895 *induced* increased mRNA levels of MIP-2 , MCP-1 , RANTES , inducible NO synthase (iNOS) , and [cyclooxygenase-2 (COX-2)] in the IEC-18 cell line . Positive_regulation PTGS2 IL1B 17040496 1631056 Bidens pilosa suppresses *induced* [cyclooxygenase-2] expression through the inhibition of mitogen activated protein kinases phosphorylation in normal human dermal fibroblasts . Positive_regulation PTGS2 IL1B 17040496 1631058 *induced* [COX-2] expression was regulated by MAPK pathways , especially by p38 . Positive_regulation PTGS2 IL1B 17046175 1674723 We found that *increased* the expression levels of cPLA(2) and [COX-2] , and also increased the secretion of PGE ( 2 ) . Positive_regulation PTGS2 IL1B 17068133 1683961 Short-term incubation of Leydig cells with TGF-alpha or also *increased* [COX2] protein levels ; Positive_regulation PTGS2 IL1B 17085450 1685066 We have further demonstrated that , in fibroblast-like synoviocytes ( FLSs ) , AuTM acts as a specific COX-2 transcriptional repressor in that *induced* [COX-2] transcription is blocked , whereas COX-1 transcription and translation is unaffected . Positive_regulation PTGS2 IL1B 17105783 1676627 stimulated release of PGE ( 2 ) by HMSM cells and *increased* [COX-2] and mPGES-1 mRNA and protein expression . Positive_regulation PTGS2 IL1B 17133356 1677751 Role of atypical protein kinase C isozymes and NF-kappaB in *induced* expression of [cyclooxygenase-2] in human myometrial smooth muscle cells . Positive_regulation PTGS2 IL1B 17133356 1677756 We have identified a role for atypical protein kinase C ( PKC ) isozymes in *induced* [Cox-2] expression in human myometrial smooth muscle cells ( HMSMC ) . Positive_regulation PTGS2 IL1B 17133356 1677799 Our findings indicate that induced Cox-2 expression in HMSMC in culture *requires* p38-MAPK mediated mRNA stabilization and an independent activation of [Cox-2] transcription which is dependent on the action of atypical PKCs , probably through direct stimulation of the transactivating activity of NF-kappaB . Positive_regulation PTGS2 IL1B 17186945 1695297 Using specific PPARgamma agonist ( rosiglitazone ) , PPARgamma ligand ( 15-deoxy-Delta12,14-PGJ ( 2 ) ) , and PPARgamma inhibitor ( GW9662 ) , we confirm that activation of PPARgamma blocks induced *up-regulation* of [COX-2] , mPGES-1 , and their derived PGE ( 2 ) . Positive_regulation PTGS2 IL1B 17208222 1695804 We found that thalidomide inhibited the *mediated* induction of [COX-2] protein and mRNA in Caco-2 cells . Positive_regulation PTGS2 IL1B 17208222 1695805 Transient transfection with a COX-2 promoter construct demonstrated that thalidomide did not affect *induced* transcriptional activation of [COX-2] , although it did decrease the stability of COX-2 mRNA and suppress IL-1beta induced cytoplasmic shuttling of an mRNA stabilizing protein , HuR . Positive_regulation PTGS2 IL1B 17249620 1664364 NPD1 also inhibited *stimulated* expression of [COX-2] . Positive_regulation PTGS2 IL1B 17296257 1815458 Suppression of *induced* [COX-2] expression by trichostatin A (TSA) in human endometrial stromal cells . Positive_regulation PTGS2 IL1B 17296257 1815459 Following our observation that histone deacetylase inhibitors (HDACIs) trichostatin A (TSA) and valproic acid ( VPA ) can suppress proliferation of endometrial stromal cells , we sought to determine whether TSA suppresses *induced* [COX-2] expression in endometrial stromal cells . Positive_regulation PTGS2 IL1B 17296257 1815460 *stimulated* [COX-2] expression in a concentration dependent manner in endometrial stromal cells . Positive_regulation PTGS2 IL1B 17314019 1726150 Boiled LJ extracts also inhibited expression of *induced* [COX-2] protein expression and suppressed its mRNA induction by IL-1beta in A549 cells . Positive_regulation PTGS2 IL1B 17317723 1740854 Inhibitors of EGFR and phosphatidylinositol-3-kinase also abolished both the *mediated* modulation of the Akt/GSK-3beta/beta-catenin pathway and enhancement of [COX-2] expression . Positive_regulation PTGS2 IL1B 17328065 1711912 PGE ( 2 ) formation and [cyclooxygenase 2 (COX-2)] protein expression were *induced* by and potentiated by kinins with affinity for the B1 or B2 receptors , resulting in PGE ( 2 ) -dependent enhancement of RANKL . Positive_regulation PTGS2 IL1B 17481552 1738701 In this review , we provide evidence for reduced [COX-2] transcriptional expression in *response* to phorbol esters ( PMA ) , lipopolysaccharide (LPS) , and tumor necrosis factor alpha (TNFalpha) . Positive_regulation PTGS2 IL1B 17481556 1738708 Similarly , over-expression of 15-PGDH by the same strategy inhibited *induced* [COX-2] expression . Positive_regulation PTGS2 IL1B 17510469 1761927 *induced* expression and activation of inducible nitric oxide synthase and [cyclooxygenase-2] were inhibited by apoE in vascular smooth muscle cells ( VSMCs ) . Positive_regulation PTGS2 IL1B 17574271 1792286 In vitro , Ro26-2198 inhibited induced ERK activation and [COX-2] *induction* and decreased HCA-7 cell proliferation . Positive_regulation PTGS2 IL1B 17600562 1765097 *induction* of [COX-2] protein is prevented by treatment with a nuclear factor (NF)-kappaB inhibitor , and oestrogen treatment reduces cerebrovascular NF-kappaB activity . Positive_regulation PTGS2 IL1B 17625924 1858007 It also inhibits *induced* expression of the pro-inflammatory genes iNOS and [COX-2] and restores TGF-beta receptors I and II ( TGF-betaRI and RII ) mRNA levels . Positive_regulation PTGS2 IL1B 17644810 1771511 These results , along with recent findings that TSA suppresses proliferation , *induced* [cyclo-oxygenase 2] expression , and constitutive or TNFalpha stimulated nuclear factor kappa B activation in endometrial and endometriotic cells , makes histone deacetylase inhibitors a promising class of compounds for novel and more effective medical treatment of endometriosis , especially given the mounting evidence that endometrios be an epigenetic disease . Positive_regulation PTGS2 IL1B 17683829 1794178 Second , we observed that [cox-2] *activation* by was essential to generate changes in ligand/receptor gene expression . Positive_regulation PTGS2 IL1B 17910039 1888899 Using a retrovirus mediated gene expression approach we demonstrate that overexpression of GILZ inhibits TNF-alpha and *induced* [COX-2] mRNA and protein expression , and knockdown of GILZ by shRNA reduces glucocorticoid inhibition of cytokine induced COX-2 expression . Positive_regulation PTGS2 IL1B 17982107 1821084 In this study , we report that the *induction* of [PGHS-2] by is dramatically enhanced and prolonged when Jak2 signaling is abrogated , either with the specific inhibitor AG490 or by transiently transfecting fibroblasts with a dominant negative mutant Jak2 . Positive_regulation PTGS2 IL1B 17982107 1821085 sPLA ( 2 ) expression following transfection resulted in increased *dependent* [PGHS-2] and microsomal PGE ( 2 ) synthase levels . Positive_regulation PTGS2 IL1B 18097066 1847511 In this study , we examine the role of *mediated* induction of [cyclooxygenase-2] and PGE2 , and evaluate the significance of individual E prostanoid ( EP ) receptors in mediating the fibroproliferative effects of IL-1beta in ALI . Positive_regulation PTGS2 IL1B 18174279 1883131 similarly *induced* expression of [cyclooxygenase-2] , but the cyclooxygenase-2 expression was , in contrast , further enhanced by IL-1 receptor antagonist . Positive_regulation PTGS2 IL1B 18306389 1891695 Treatment of OVCAR-3 cells with LMB revealed a significant reduction of cell proliferation and increased apoptosis as well as suppressed *induced* [COX-2] expression . Positive_regulation PTGS2 IL1B 18314621 1840087 DNA binding avtivity as well as COX-2 mRNA and protein expression were strongly inducible by IL-1beta treatment in OVCAR-3 cells , while p65 siRNA inhibited *dependent* p65 activity ( p = 0.037 ) as well as [COX-2] expression on the mRNA ( p < 0.03 ) and on the protein level . Positive_regulation PTGS2 IL1B 18348730 1925338 *induced* a transient increase in [COX-2] expression and stimulated the cumulative production of PGE2 release . Positive_regulation PTGS2 IL1B 18448096 1915806 Aurothiomalate inhibited *induced* [COX-2] protein expression and PGE ( 2 ) production in chondrocytes in a dose dependent manner . Positive_regulation PTGS2 IL1B 18456507 1921358 15-Deoxy-delta12,14-prostaglandin-J ( 2 ) ( 15d-PGJ ( 2 ) ) has potent anti-inflammatory effects including the inhibition of *induced* expression of [cyclooxygenase-2 (COX-2)] and prostaglandin E ( 2 ) ( PGE ( 2 ) ) production in several cell types . Positive_regulation PTGS2 IL1B 18456507 1921360 Furthermore , preincubation with 15d-PGJ ( 2 ) inhibited IL-1beta induced PGE ( 2 ) production although *induced* [COX-2] expression remained unaffected by the treatment with 15d-PGJ ( 2 ) . Positive_regulation PTGS2 IL1B 18485347 1921713 Furthermore , western blot analysis revealed that overexpression of DSCR1-4 in SK-N-SH neuroblastoma cells attenuated *induced* [cyclooxygenase 2] and intercellular adhesion molecule 1 expression . Positive_regulation PTGS2 IL1B 18571585 1930063 U937 conditioned medium and *stimulated* expression of [cyclooxygenase-2] and prostaglandin E ( 2 ) production in pancreatic cancer cells , which was mediated by activation of the ERK1/2 pathway . Positive_regulation PTGS2 IL1B 18571585 1930064 Mononuclear cells protect pancreatic cancer cells from drug induced apoptosis in vitro by *mediated* expression of [cyclooxygenase-2] and production of prostaglandins . Positive_regulation PTGS2 IL1B 18703638 1974314 In SEMFs , S1P amplifies *induced* [COX-2] expression through increased mRNA stability . Positive_regulation PTGS2 IL1B 18723875 1955945 Using a pharmacological approach , we demonstrated that in primary cultures of myometrial cells from d-19 pregnant rats , induction of [COX2] was *mediated* by 4beta-phorbol 12,13-dibutyrate and through sequential activation of PKC , ERK1/2 , and SphK1 . Positive_regulation PTGS2 IL1B 18827362 1970797 These data suggest that troglitazone is capable of increasing *induced* [COX-2] and iNOS expression through an IkappaBalpha dependent mechanism in VSMC from WKY and SHR . Positive_regulation PTGS2 IL1B 18836229 1971258 Real-time quantitative PCR analysis revealed that *enhanced* iNOS and [COX-2] mRNA levels , with the maximum expression at 6 or 12 hours . Positive_regulation PTGS2 IL1B 18840637 2012919 The induction of 11beta-HSD1 by IL-1beta was further increased by cortisol , whereas the *induction* of [cyclooxygenase 2] by was inhibited by cortisol . Positive_regulation PTGS2 IL1B 18840637 2012920 Nuclear factor kappaB activation inhibitor could only block the *induction* of [cyclooxygenase 2] but not 11beta-HSD1 by , suggesting that different mechanisms were utilized by IL-1beta in the regulation of 11beta-HSD1 versus proinflammatory mediators . Positive_regulation PTGS2 IL1B 19029777 1992436 *Induction* of [cyclooxygenase-2] expression by in human glioma cell line , U87MG . Positive_regulation PTGS2 IL1B 19029777 1992437 *induced* [COX-2] expression strongly at both protein and messenger ribonucleic acid levels in only the U87MG cells of the glioma cell lines . Positive_regulation PTGS2 IL1B 19135800 2037695 We also show that *induces* [COX-2] expression and prostaglandin release in DRG neurons in vitro in a MAP kinase dependent fashion . Positive_regulation PTGS2 IL1B 19235895 2072393 *up-regulated* the [COX-2] expression in enteric glial cells . Positive_regulation PTGS2 IL1B 19390242 2082017 These data suggest that the profound effects of COX-2 silencing on inhibiting invasion , tumor growth and metastasis from MDA-MB-231 cells are dependent on the induction of *dependent* [COX-2] and HIF-1alpha but are independent of hypoxia Positive_regulation PTGS2 IL1B 19393083 2082051 Further studies demonstrated that treatment of mammary epithelial cells with *induced* expression of [cyclooxygenase (Cox)-2] both in vitro and in vivo . Positive_regulation PTGS2 IL1B 19423159 2089902 Cx43 liposomes containing a soluble NEMO binding domain peptide suppressed the intracellular signaling cascade *induced* NF-kappaB activation and [cyclooxygenase-2] expression in Cx43 expressing cells , confirming effective peptide transfer into the cell . Positive_regulation PTGS2 IL1B 19444759 2078676 *increases* the production of PGE ( 2 ) , [COX-2] , and the PG receptor EP4 in cultured human chondrocytes . Positive_regulation PTGS2 IL1B 19452719 2084476 Stronger expressions of [COX-2] and PGE2 *induced* by hypoxia and/or than control were detected on different time ( P < 0.05 ) . Positive_regulation PTGS2 IL1B 19452719 2084478 Hypoxia and/or effectively *induce* [COX-2] expression and PGE2 release in HNE . Positive_regulation PTGS2 IL1B 19520558 2128565 Moreover , NPD1 inhibits *stimulated* expression of [cyclooxygenase-2 (COX-2)] . Positive_regulation PTGS2 IL1B 19580863 2142579 [COX2] *up-regulation* by silica and was eliminated by IL-1 ra . Positive_regulation PTGS2 IL1B 19656660 2125726 In HSF cells , treatment *induced* [COX-2] and MMP-13 expressions in association with activation of ERKs , p38 MAPK , JNKs , and NF-kappaB . Positive_regulation PTGS2 IL1B 19728558 2134072 Stimulation of the cells with *induced* a series of proinflammatory genes ( IL1alpha , IL1beta , TNFalpha , IL8 , monocyte chemoattractant peptide-1 and [COX-2] ) , but if the cells were treated with hyperthermia prior to IL1beta expression , gene expressions were significantly decreased up to 8 h. Treatment with sulfur alone induced expression of observed genes up to 12 h . Positive_regulation PTGS2 IL1B 19763723 2247725 In vitro , muscone reversed *induced* upregulation of IL-1beta , tumor necrosis factor alpha , [cyclooxygenase 2] , inducible nitric oxide synthase , matrix metalloproteinase 13 , aggrecanase 2 , and nitric oxide and downregulation of Col2alpha1 and aggrecan . Positive_regulation PTGS2 IL1B 19776509 2141012 Involvement of protein kinase C in *induced* expression of [cyclooxygenase-2] in human gingival fibroblasts . Positive_regulation PTGS2 IL1B 19777241 2271934 Effects of ( - ) -epigallocatechin-3-gallate on [cyclooxygenase 2] , PGE ( 2 ) , and IL-8 expression *induced* by in human synovial fibroblasts . Positive_regulation PTGS2 IL1B 19802674 2148240 markedly *enhanced* the expression of [COX-2] and microsomal prostaglandin E synthase-1 ( mPGES-1 ) at both the mRNA and protein levels . Positive_regulation PTGS2 IL1B 19802674 2148241 Interestingly , in a dose dependent manner , PGE ( 2 ) recovered mPGES-1 expression from suppression by DEX , whereas it did not restore the expression of [COX-2] in the *presence* of DEX and . Positive_regulation PTGS2 IL1B 19918789 2209947 Our results showed that PA (1) inhibited anchorage dependent and -independent A549 growth in a concentration dependent manner , ( 2 ) induced apoptosis and disrupted mitochondrial membrane potential in A549 cells , and at nonlethal levels , ( 3 ) decreased induced *activation* of cPLA(2) and [COX-2] , ( 4 ) suppressed IL-1 beta induced activation of mitogen activated protein kinases ( MAPKs ) , and ( 5 ) inhibited IL-1 beta stimulated nuclear factor kappa B (NF-kappaB) signaling pathways . Positive_regulation PTGS2 IL1B 20337883 2287569 Ten and 40 microg/mL of hBD-3 up-regulated COX-2 mRNA and protein expression , consistent with [COX-2] *up-regulation* by , whereas hBD-1 and hBD-2 did not . Positive_regulation PTGS2 IL1B 20424388 2262545 Identification of cells expressing [cyclooxygenase-2] in *response* to in rat aortae . Positive_regulation PTGS2 IL1B 20424388 2262547 *induced* [COX-2] expression was also detected in medial smooth muscle cells of endothelium denuded aortae and cultured rat aortic smooth muscle cells . Positive_regulation PTGS2 IL1B 20424388 2262549 Thus , *induces* [COX-2] through the ERK mediated pathway in adventitial fibroblasts and macrophages of healthy aortae ; Positive_regulation PTGS2 IL1B 20717505 2306733 AF pellet resulted in dose dependent iNOS and [COX-2] expression in *response* to , stimulation , demonstrating that 1 ng/ml for 24 hours yielded a maximal response . Positive_regulation PTGS2 IL1B 20717945 2312999 Inhibition of the p50 and p65 subunits of NF-kappaB decreased *induced* [COX-2] transcription . Positive_regulation PTGS2 IL1B 21856929 2496234 The PRPr also reduced *induced* increase of ADAMTS4 and [PTGS2] gene expression . Positive_regulation PTGS2 IL1B 22572995 2638061 *increased* expression of PTGS1 and [PTGS2] genes that are rate limiting for PG synthesis in the uterine endometrium . Positive_regulation PTGS2 IL1B 22572995 2638066 Collectively , the results indicated that regulates expression of IL1R1 and IL1RAP and *stimulates* expression of PTGS1 and [PTGS2] that are considered to be the most rate limiting enzymes for endometrial synthesis of PGs during the peri-implantation period of pregnancy in pigs . Positive_regulation PTGS2 IL1B 7575673 329069 Expression of [PGHS-2] *induced* by either LPS or was blocked by the IL-1 receptor antagonist ( IL-1ra , 2 micrograms/mL ) but not by rolipram , a phosphodiesterase IV inhibitor that inhibits TNF alpha but not IL-1 beta release . Positive_regulation PTGS2 IL1B 7575673 329070 Similar to LPS , *induced* [PGHS-2] expression was apparently not regulated by lipid mediators such as prostaglandins , leukotrienes or PAF as determined with specific inhibitors and antagonists . Positive_regulation PTGS2 IL1B 7575673 329071 Furthermore , marine natural products such as scalaradial have novel effects on the *mediated* induction of [PGHS-2] in human monocytes , which appears to be independent of effects on lipid mediator production . Positive_regulation PTGS2 IL1B 7582449 333529 This study investigates whether endogenous , TNF-alpha , EGF or PDGF *contribute* to the induction of [COX-2] elicited by LPS in BAEC and if their action is due to activation of tyrosine kinase . Positive_regulation PTGS2 IL1B 7615528 314991 Overall , these results indicate that COXs are responsible for the oxidative metabolism of linoleic acid in HUVEC , and *increases* it by inducing the expression of new enzyme , mainly [COX2] . Positive_regulation PTGS2 IL1B 7637265 317512 *regulates* rat mesangial [cyclooxygenase II] gene expression by tyrosine phosphorylation . Positive_regulation PTGS2 IL1B 7637265 317514 *Induction* of [COX II] by was mimicked by incubating the cells in the presence of a protein tyrosine phosphatase inhibitor , vanadate . Positive_regulation PTGS2 IL1B 7637265 317515 Immunoprecipitation of mesangial cell lysates with agarose conjugated antiphosphotyrosine antibody and Western analysis of precipitated proteins with anti-ERK2 antibody demonstrate that the 39/40 kD protein phosphorylated on tyrosine is ERK2 and suggests participation of one of the MAP kinase family of extracellular receptor kinases in *stimulated* induction of the [COX II] gene . Positive_regulation PTGS2 IL1B 7873203 296656 Dexamethasone inhibited the *induced* mRNA expression of [cyclooxygenase-2] whereas IL-4 failed . Positive_regulation PTGS2 IL1B 7873203 296660 These results indicate that *induces* [cyclooxygenase-2] rather than cyclooxygenase-1 in IMR-90 cells and this induction is responsible for the augmentation of PGE2 production stimulated with IL-1 beta . Positive_regulation PTGS2 IL1B 7890656 299437 Radiciciol also suppressed the [COX-2] expression *induced* by in rat smooth muscle cells . Positive_regulation PTGS2 IL1B 7896894 299939 inhibitors of protein kinase A (PKA) or tyrosine kinase ( TK ) had only a limited effect on *induced* [PGHS-2] mRNA expression . Positive_regulation PTGS2 IL1B 8048967 267166 Dexamethasone suppression of *induced* [cyclooxygenase 2] expression is not mediated by lipocortin-1 in A549 cells . Positive_regulation PTGS2 IL1B 8274023 239528 In rat vascular smooth muscle cells , selectively *increased* the expression of [COX-2] , but not that of COX-1 , as assessed by enzyme activity , immunoprecipitation of COX proteins , and mRNA analysis . Positive_regulation PTGS2 IL1B 8526991 336632 *induces* [cyclooxygenase-2] in cultured human decidual cells . Positive_regulation PTGS2 IL1B 8579596 350555 Two mechanistically distinct tyrosine kinase inhibitors , genistein and herbimycin A , block the *induction* of [cyclooxygenase-2 (COX-2)] and inducible nitric oxide synthase (iNOS) by in rat mesangial cells . Positive_regulation PTGS2 IL1B 8606975 342723 For example , in amnion cells induces a rapid *increase* in [PGHS-2] mRNA levels followed by a decrease to undetectable levels within 4 h of treatment ; Positive_regulation PTGS2 IL1B 8621794 360165 however , they both potentiated *induced* mRNA and protein expression of [COX-2] . Positive_regulation PTGS2 IL1B 8632179 361554 *induces* [prostaglandin G/H synthase-2] ( cyclooxygenase-2 ) in primary murine astrocyte cultures . Positive_regulation PTGS2 IL1B 8654401 358802 Northern blot analysis showed that TNF alpha and *increased* both PLA2 and inducible cyclooxygenase ( [Cox-2] ) mRNA transcription . Positive_regulation PTGS2 IL1B 8662662 365416 We therefore evaluated the effects of antioxidants on *induced* [cyclooxygenase-2 (Cox-2)] and inducible nitric-oxide synthase (iNOS) expression in rat mesangial cells . Positive_regulation PTGS2 IL1B 8662662 365417 In contrast , PDTC inhibited Cox-2 expression at the post-transcriptional level , since PDTC did not affect *induced* [Cox-2] mRNA levels but inhibited Cox-2 protein expression and prostaglandin E2 production . Positive_regulation PTGS2 IL1B 8662662 365422 Another antioxidant , rotenone , which inhibits reactive oxygen intermediate production by inhibiting the mitochondrial electron transport system , did not inhibit IL-1beta induced iNOS and Cox-2 mRNA expression but inhibited iNOS and Cox-2 protein expression , suggesting a post-transcriptional target for the inhibition of NOS and [Cox-2] expression *induced* by . Positive_regulation PTGS2 IL1B 8711133 371300 Using RT-PCR , we found that ( 0.1 ng/ml ) coordinately *induced* both cPLA2 and [PGHS-2] mRNA expression within 2 hours . Positive_regulation PTGS2 IL1B 8711133 371302 The synthetic glucocorticoid dexamethasone ( 10 ( -10 ) -10 ( -6 ) M ) inhibited *induced* cPLA2 and [PGHS-2] mRNA expression activity and protein synthesis and PGE2 release in a concentration dependent manner . Positive_regulation PTGS2 IL1B 8852950 387891 Northern blot analysis determined that *induced* [PGHS-2] expression by 30 minutes and mRNA levels were maximal by 1-2 h. Cycloheximide potentiated the accumulation of PGHS-2 mRNA linearly up to 8 h. Dexamethasone , an inhibitor of the induction of PGHS-2 , inhibited IL-1 beta induced PGHS-2 mRNA expression and also suppressed IL-1 beta stimulated formation of TRAP positive MNC . Positive_regulation PTGS2 IL1B 8852950 387892 Moreover , *induced* [PGHS-2] mRNA expression and formation of TRAP positive MNC were inhibited by calphostin C , a selective inhibitor of protein kinase C ( PKC ) . Positive_regulation PTGS2 IL1B 8872612 389696 Prostaglandin E2 , transforming growth factor-beta , and variably *regulate* the expression of cyclooxygenase 1 , [cyclooxygenase 2] , and lysyl oxidase in IMR90 , human embryo lung fibroblasts . Positive_regulation PTGS2 IL1B 9041934 416037 These data demonstrate that signaling via the NF-kappa B pathway is involved in regulation of [COX-2] expression *induced* by in RA synoviocytes . Positive_regulation PTGS2 IL1B 9138698 424226 and TNF alpha *increased* [COX-2] activity and an additional small increase was produced by the three cytokines in combination . Positive_regulation PTGS2 IL1B 9144511 429631 However , suppression of PGHS-2 expression is not the result of suppressed cytokine production , because SK & F 86002 suppressed [PGHS-2] expression *initiated* by and TNF-alpha , in addition to other stimuli . Positive_regulation PTGS2 IL1B 9179403 434361 The glucocorticosteroid dexamethasone and protein synthesis inhibitors , cycloheximide and actinomycin D , not only markedly inhibited IL-1 beta stimulated PGE2 release and COX activity but also suppressed *induced* [COX-2] induction . Positive_regulation PTGS2 IL1B 9187256 437024 We have used *induced* [COX-2] in human A549 cells to investigate the mechanism of action of salicylate on COX-2 activity . Positive_regulation PTGS2 IL1B 9266823 449504 produces a 10-fold induction of COX-2 mRNA and an 8-fold *increase* in [COX-2] transcription that was temporally preceded by activation of the transcription factor nuclear factor-kappaB (NF-kappaB) . Positive_regulation PTGS2 IL1B 9327757 457308 Thus , we have compared the ability of segments of human saphenous vein and internal mammary artery , obtained from the same patient , to express [COX-2] activity and mRNA after organ culture in the *presence* and absence of . Positive_regulation PTGS2 IL1B 9405225 469732 Supplementing HMC with the BH4 donor sepiapterin potentiated *induced* [COX-2] expression by approximately 2-fold . Positive_regulation PTGS2 IL1B 9414112 471661 However , superinduction of *induced* [COX-2] mRNA levels by cycloheximide in pulmonary type II A549 cells occurred by increased transcription and not by mRNA stabilisation . Positive_regulation PTGS2 IL1B 9452008 475515 Both platelet activating factor and , potent mediators of the inflammatory and immune response , strongly *induce* transcription of the [cyclooxygenase-2 (COX-2)] gene in brain cells . Positive_regulation PTGS2 IL1B 9467571 485621 *induces* [cyclooxygenase-2] gene expression in cultured endometrial stromal cells . Positive_regulation PTGS2 IL1B 9467571 485622 Here we report the *induction* of [COX-2] gene expression by in cultured human endometrial stromal cells . Positive_regulation PTGS2 IL1B 9467571 485624 [COX-2] activity was *induced* by ( 1 ng/mL ) ; Positive_regulation PTGS2 IL1B 9515807 492237 Consistent with these findings , *induced* [COX-2] mRNA expression and protein production in A549 cells . Positive_regulation PTGS2 IL1B 9517759 492342 COX-1 and *induced* [COX-2] mRNA expression were not inhibited by MTX . Positive_regulation PTGS2 IL1B 9520467 493651 Budesonide epimer R or dexamethasone selectively inhibit platelet activating factor induced or *induced* DNA binding activity of cis acting transcription factors and [cyclooxygenase-2] gene expression in human epidermal keratinocytes . Positive_regulation PTGS2 IL1B 9568691 501330 The current studies were designed to characterize the involvement of protease ( s ) in the signaling pathway of *induced* iNOS and [COX-2] expression by rat islets and transformed rat pancreatic beta-cells . Positive_regulation PTGS2 IL1B 9568691 501331 In an analogous manner , TLCK ( 100 micromol/l ) and MG 132 ( 10 micromol/l ) inhibited *induced* [COX-2] enzyme activity ( PGE2 formation ) and COX-2 gene expression at the level of mRNA and protein . Positive_regulation PTGS2 IL1B 9568691 501334 The transcription factor NFkappaB is essential for activation of a number of cytokine-inducible enzymes and was evaluated as a possible site of protease action necessary for *induced* coexpression of iNOS and [COX-2] . Positive_regulation PTGS2 IL1B 9571196 501690 *induced* [COX-2] but not COX-1 protein . Positive_regulation PTGS2 IL1B 9575890 502709 The inflammatory cytokine *induces* both [cyclooxygenase-2 (Cox-2)] and the inducible nitric oxide synthase (iNOS) with concomitant release of PGs and nitric oxide ( NO ) by glomerular mesangial cells . Positive_regulation PTGS2 IL1B 9575890 502714 We demonstrate that both insulin and IGF-I increase *induced* [Cox-2] and iNOS protein expression , which in turn enhance PGE2 and NO production . Positive_regulation PTGS2 IL1B 9633531 513129 Analysis of fibroblast proteins showed the induction of cyclooxygenase-1 (Cox-1) by TGF-beta 1 and the *induction* of [Cox-2] by and TNF-alpha . Positive_regulation PTGS2 IL1B 9633531 513133 In vitro transcription assays showed that and TNF-alpha *increased* the transcription of the [Cox-2] gene , whereas TGF-beta 1 had no effect . Positive_regulation PTGS2 IL1B 9633531 513135 In summary , we demonstrate that the potentiation of PGE2 production by TGF-beta 1 in IL-1 beta and TNF-alpha treated fibroblasts is the result of transcriptional *stimulation* of the [Cox-2] gene by and TNF-alpha and the stabilization of the resulting transcripts by TGF-beta 1 . Positive_regulation PTGS2 IL1B 9705828 526077 We have previously demonstrated that *causes* an induction of [COX-2] in human vascular smooth muscle ( 1 ) . Positive_regulation PTGS2 IL1B 9725242 529619 The down-regulatory effect of IFN-gamma on *induced* [COX-2] expression was abrogated with cycloheximide . Positive_regulation PTGS2 IL1B 9728043 530011 The purpose of this study was to determine whether prostanoids released as a result of [cyclooxygenase-2 (COX-2)] *induction* by contribute to this effect of the cytokine . Positive_regulation PTGS2 IL1B 9728043 530012 Western blot analysis confirmed the *induction* of [COX-2] by . Positive_regulation PTGS2 IL1B 9780320 540596 The purpose of the present study was to determine the cell-type ( s ) responsible for the *induced* [PGHS-2] expression in amnion cultures . Positive_regulation PTGS2 IL1B 9786861 540907 *induced* [cyclooxygenase-2] expression requires activation of both c-Jun NH2-terminal kinase and p38 MAPK signal pathways in rat renal mesangial cells . Positive_regulation PTGS2 IL1B 9786861 540908 The inflammatory cytokine *induces* [cyclooxygenase-2 (Cox-2)] expression with a concomitant release of prostaglandins from glomerular mesangial cells . Positive_regulation PTGS2 IL1B 9786861 540925 Similarly , overexpression of the kinase-dead form of p38 MAPK also inhibits *induced* [Cox-2] expression and PGE2 production . Positive_regulation PTGS2 IL1B 9786861 540969 This study suggests that the activation of both JNK/SAPK and p38 MAPK signaling cascades is required for *induced* [Cox-2] expression and PGE2 synthesis . Positive_regulation PTGS2 IL1B 9797107 543509 Phorbol 12-myristate 13-acetate ( 30 nM ) and ( 100 ng/mL ) *increased* [COX-2] promoter activity by 2.6-fold and 2.2-fold , respectively . Positive_regulation PTGS2 IL1B 9797107 543510 *Induction* of [COX-2] by and PMA suggests that COX-2 and prostaglandin have important roles in the growth and differentiation of endometrial stromal cells . Positive_regulation PTGS2 IL1B 9815044 546500 These results indicate that COX-2 protein is highly localized in the base of gastric ulcers in rats and that [COX-2] mRNA expression might be *regulated* positively by and TNF-alpha and negatively by TGF-beta1 . Positive_regulation PTGS2 IL1B 9834469 553535 IL-1ra decreased *induced* [COX-2] mRNA expression by about half and significantly increased cPLA2 protein levels , as detected by immunoblotting , when used alone and together with IL-1beta . Positive_regulation PTGS2 IL1B 9863663 556126 We have reported that *induces* [cyclo-oxygenase-2 (COX-2)] in human ASM cells and results in a marked increase in prostanoid generation with PGE2 and PGI2 as the major products . Positive_regulation PTGS2 ITGB2 11123339 768815 In contrast , for optimal induction of [COX-2] , IL-12 p35 , and IL-12 p40 genes by low concentrations of LPS or by all concentrations of Taxol , was also *required* . Positive_regulation PTGS2 ITGB2 17927697 1819599 We report that ACT induces [COX-2] in a manner that absolutely requires the catalytic activity of this enzyme and expression dramatically *enhanced* the sensitivity of cells to ACT dependent COX-2 induction . Positive_regulation PTGS2 KRT38 12604670 1062687 Although COX-1 expression in keratinocytes remained unchanged during wound healing , [COX-2] expression was *induced* coincidentally with keratinocyte proliferation and 6 expression , suggesting a role for COX-2 in epidermal repair . Positive_regulation PTGS2 MAP2K6 10671533 666834 pharmacologic inhibition of *blocked* B [ a ] P-mediated induction of [COX-2] . Positive_regulation PTGS2 MAP2K6 11085935 750771 Similarly , activation of JNK by Ad-MKK7D and p38-MAPK by *resulted* in the increased expression of [PGHS-2] . Positive_regulation PTGS2 MAP2K6 11234900 789717 The induction of [COX-2] by EGF was *suppressed* by inhibitors of tyrosine kinase activity , phosphatidylinositol 3-kinase , , and p38 mitogen activated protein kinase . Positive_regulation PTGS2 MAP2K6 11520057 851904 The inhibitor ( PD098059 ) *prevented* EGCG induced [COX-2] expression , whereas sodium orthovanadate ( protein-tyrosine phosphatase inhibitor ) significantly enhanced COX-2 expression and PGE ( 2 ) production . Positive_regulation PTGS2 MAP2K6 11680608 873826 An NF-kappaB inhibitor ( pyrrolidine dithiocarbamate ) , a MAP kinase ( ) inhibitor ( PD98059 ) , and a p38 MAP kinase inhibitor ( SB203580 ) significantly *suppressed* the [COX-2] gene transcription and PGE2 synthesis in the neutrophils . Positive_regulation PTGS2 MAP2K6 12649265 1080091 These results provide direct evidence that mediated p38 MAPK activation is necessary for interleukin-1beta induced cardiac myocyte COX-2 gene expression and PGE2 biosynthesis in vitro and is *sufficient* for [COX-2] gene expression by cardiac myocytes in vitro and in vivo . Positive_regulation PTGS2 MAP2K6 12930301 1132329 Inhibitors of , p38 MAP kinase and PI3-kinase , *suppressed* the induction of [COX-2] expression by UV . Positive_regulation PTGS2 MAP2K6 14530261 1174741 Expression of [COX-2] was partially *blocked* by U0126 , a inhibitor , and SB 203580 , a p38 MAPK inhibitor . Positive_regulation PTGS2 MAP2K6 15238218 1269813 Induction of [COX-2] and c-Jun by EGF was completely *suppressed* by inhibitor combined with JNK inhibitor . Positive_regulation PTGS2 MAP2K6 15525691 1359969 In addition , 2,2',4,6,6'-PeCB stimulated [COX-2] induction was *reduced* by the specific MAPK kinase ( ) inhibitor , PD98059 , and in p53-deficient cells , implying that COX-2 induction requires the activation of ERK1/2 MAPK and p53 . Positive_regulation PTGS2 MAP2K6 15567061 1355325 PMA induced [COX-2] expression was *attenuated* by PKC inhibitors ( Go 6976 and Ro 31-8220 ) , a Ras inhibitor ( manumycin A ) , a Raf-1 inhibitor ( GW 5074 ) , a inhibitor ( PD 098059 ) , and an NF-kappaB inhibitor ( PDTC ) , but not by a tyrosine kinase inhibitor ( genistein ) or a p38 MAPK inhibitor ( SB 203580 ) . Positive_regulation PTGS2 MAP2K6 16044407 1453661 Chemical inhibitors of ( PD98059 ) , p38 ( SB202190 ) , but not JNK ( SP600125 ) *blocked* TPA induction of [COX-2] although apigenin did not inhibit TPA mediated COX-2 expression through these pathways . Positive_regulation PTGS2 MAP2K6 16083714 1442897 activation *led* to increased expression of [COX-2] , Bcl-X ( L ) , Mcl-1 , and phosphorylated Bad and decreased expression of Bak . Positive_regulation PTGS2 MAP2K6 16088958 1460677 Both inhibitors of ( PD098059 ) and JNK ( SP600125 ) *inhibited* serum induction of [COX-2] . Positive_regulation PTGS2 MAP2K6 16598755 1598217 Inhibition of PKC activity , activity , or Ca2+ signaling *blocked* agonist induction of [COX-2] and mPGES-1 . Positive_regulation PTGS2 MAP2K6 16696851 1560409 Together , these findings suggest that the molecular mechanisms of SP release by bradykinin involve the activation of , and also *require* the de novo protein synthesis of [COX-2] in DRG neurons . Positive_regulation PTGS2 MAP2K6 17600311 1804618 EGF receptor (EGFR) inhibition , neutralizing antibody against amphiregulin , or ( MEK ) inhibition *blocked* TGF-beta1 mediated [COX-2] induction . Positive_regulation PTGS2 MAP2K6 19074839 2002659 In HNSCC cells , the bradykinin induced expression of [COX-2] was *inhibited* by the EGFR kinase inhibitor gefitinib or inhibitors ( PD98059 or U0126 ) . Positive_regulation PTGS2 MAP2K6 19715751 2158149 Both MMP-9 and [COX-2] expression were significantly *increased* by overexpression . Positive_regulation PTGS2 MAP2K6 20660715 2311034 Inhibitors of signaling *suppressed* TPA/capsaicin induced [COX-2] expression in TRPV1/KO cells , indicating that activation of EGFR and its downstream signaling is involved in COX-2 elevation . Positive_regulation PTGS2 MAP2K6 22824620 2670696 Additionally , inhibitor ( U0126 ) significantly *attenuated* arsenite induced expression of Caveolin-1 , IKKß and [COX-2] while reducing eNOS expression . Positive_regulation PTGS2 MATN2 19840795 2165269 stimulation *leads* to the induction of MMP1 , MMP3 , MMP13 , [COX-2] , iNOS , IL-1beta , TNFalpha , IL-6 and IL-8 . Positive_regulation PTGS2 MMP28 22227567 2550720 In the current study , we determined whether *induced* [cyclooxygenase-2] expression was coupled to the expression of prostaglandin E synthase family members . Positive_regulation PTGS2 MMP7 22227567 2550735 In the current study , we determined whether *induced* [cyclooxygenase-2] expression was coupled to the expression of prostaglandin E synthase family members . Positive_regulation PTGS2 MMP7 23790336 2802593 The abnormal expressions of COX-2 and MMP-7 are closely related to the biological behavior of OSCC , the may be *induced* by [COX-2] , and further lead to the invasion and metastasis of OSCC . Positive_regulation PTGS2 PTGER2 11533709 854679 We conclude that is the major receptor mediating the PGE2 signal generated by COX-2 upregulation in intestinal polyposis , and that *increased* cellular cAMP stimulates expression of more [COX-2] and vascular endothelial growth factor in the polyp stroma . Positive_regulation PTGS2 PTGER2 15920732 1445799 We demonstrated that microglial was *necessary* for lipopolysaccharide (LPS) activated microglia mediated neurotoxicity , as well as induction of inducible nitric oxide synthase (iNOS) and [cyclooxygenase 2 (COX-2)] . Positive_regulation PTGS2 PTGER2 24265450 2904481 However , we have recently shown that also *activates* the proinflammatory [PG G/H synthase-2 (PGHS-2)] . Positive_regulation PTGS2 RARB 16170369 1489109 Benzo [ a ] pyrene diol epoxide ( BPDE , a carcinogen present in tobacco smoke and environmental pollution ) has been shown to suppress ( RAR-beta ( 2 ) ) and *induce* [cyclooxygenase-2 (COX-2)] expression . Positive_regulation PTGS2 RARB 16170369 1489113 This study demonstrated that BPDE suppressed expression of ( 2 ) *results* in [COX-2] induction and restoration of RAR-beta ( 2 ) expression reduces COX-2 protein in esophageal cancer cells , thereby further supporting our previous finding that RAR-beta ( 2 ) plays an important role in suppressing esophageal carcinogenesis . Positive_regulation PTGS2 RCAN1 17062574 1654650 Overexpression of .4 significantly *attenuated* the induction of [cyclooxygenase-2 (COX-2)] expression by phorbol 12-myristate 13-acetate ( PMA ) via a calcineurin independent mechanism . Positive_regulation PTGS2 RCAN1 18485347 1921712 Furthermore , western blot analysis revealed that overexpression of in SK-N-SH neuroblastoma cells *attenuated* IL-1beta induced [cyclooxygenase 2] and intercellular adhesion molecule 1 expression . Positive_regulation PTGS2 RGS2 19175184 2007093 Overexpression of *attenuated* hCG induced [COX2] transcription . Positive_regulation PTGS2 S100B 12837757 1134700 also *increased* [COX-2] mRNA expression in human peripheral blood monocytes from healthy donors . Positive_regulation PTGS2 S100B 18599158 2208610 and ( 3 ) induced *upregulation* of [COX-2] , IL-1beta and TNF-alpha expression requires the concurrent activation of NF-kappaB and AP-1 . Positive_regulation PTGS2 S100B 18854308 2000893 S100b treatment promoted the translocation of nuclear hnRNPK to cytoplasm , whereas a cytoplasmic translocation-deficient hnRNPK mutant inhibited *induced* [COX-2] mRNA stability . Positive_regulation PTGS2 S100B 18854308 2000895 Small interfering RNA mediated specific knockdown of hnRNPK blocked S100b induced COX-2 mRNA stability , whereas on the other hand , overexpression of hnRNPK increased *induced* [COX-2] mRNA stability . Positive_regulation PTGS2 SLC38A3 23376640 2747990 In addition , knockdown of STAT3 expression significantly attenuated *induced* PI3K/Akt activation , [COX-2] expression , and cell proliferation . Positive_regulation PTGS2 SPHK1 18723875 1955948 This effect was blocked by SphK inhibitors , providing evidence of the close relationship between activity and [COX2] *induction* in rat myometrium . Positive_regulation PTGS2 SPHK1 21803151 2484741 We previously demonstrated that in rat myometrium at late ( day 19 ) gestation , *increases* the expression of [COX2] via S1P generation and release . Positive_regulation PTGS2 STK39 21705614 2465719 Luteolin , a novel natural inhibitor of tumor progression locus 2 , *inhibits* tumor necrosis factor-alpha induced [cyclooxygenase-2] expression in JB6 mouse epidermis cells . Positive_regulation PTGS2 SYNM 23485615 2771909 *induced* [cyclooxygenase-2 (COX-2)] expression and nuclear factor-kappa B ( NF-?B ) activation was reduced by CK treatment . Positive_regulation PTGS2 TGM2 24009824 2714632 These observations suggested that is *involved* in TPA induced [COX-2] expression in the inflamed ear of mice and anti-inflammatory effects of glucosamine is mediated through suppression of Tgase-2 in TPA ear edema . Positive_regulation PTGS2 TGM2 24398147 2912138 Gene silencing of *reduced* the [COX-2] expression in MG63 cells . Positive_regulation PTGS2 TLR7 20138367 2227248 Nevertheless *mediated* JNK activation as well as the increased protein expression of iNOS and [COX-2] remained unchanged when Syk protein was knockdown by siRNA approach . Positive_regulation PTGS2 TLR7 20971925 2348650 We hypothesized that [Cox-2] is *induced* by activation and is necessary for optimal AMP production , and that inhibitors of Cox-2 may therefore inhibit antimicrobial action . Positive_regulation PTGS2 TNF 10210266 607498 However , the activation of NF-kappaB was not related to the expression of [COX-2] *induced* by since calpain inhibitor I blocked the activation of NF-kappaB but not the expression of COX-2 mRNA or protein . Positive_regulation PTGS2 TNF 10211885 607702 IL-4 , IL-10 , and IL-13 reduced the *induced* [COX-2] level , and IL-4 and IL-10 reduced the cPLA2 level . Positive_regulation PTGS2 TNF 10232679 611396 Oligonucleotide decoy experiments confirmed the importance of nuclear factor kappaB (NF-kappaB) activation for [COX-2] *induction* by . Positive_regulation PTGS2 TNF 10480491 643517 *induced* [cyclooxygenase 2] not only increases the vasopermeability of blood-brain barrier but also enhances the neutrophil survival in Escherichia coli induced brain inflammation . Positive_regulation PTGS2 TNF 10480491 643519 Cyclooxygenase-2 and TNFalpha were co-localized on the arterioles as well as the infiltrating neutrophils by serial-section staining , indicating that [cyclooxygenase-2] was *induced* by . Positive_regulation PTGS2 TNF 10480491 643520 This suggests that *stimulated* [cyclooxygenase-2] induction play an important role on E. coli induced brain inflammation . Positive_regulation PTGS2 TNF 10484519 644148 These data suggest that *mediated* induction of [COX-2] protein expression accounted for the lag-time required for this cytokine to inhibit 86Rb uptake in MTAL cells . Positive_regulation PTGS2 TNF 10501211 648487 In keeping with these findings , produced an *increase* of [COX-2] expression , as judged from both RT-PCR studies and immunoblot of COX-2 protein , and a long lasting activation of NF-kappaB . Positive_regulation PTGS2 TNF 10560661 566657 Microinjection of IFN-gamma did not alter COX-2-ir , whereas or IL-1beta injection *induced* a moderate [COX-2-ir] in the perivascular cells of a few blood vessels close to the injection site , and in very few of the infiltrating neutrophils . Positive_regulation PTGS2 TNF 10631313 659774 In murine osteoblastic MC3T3-E1 cells which produced prostaglandin E2 as a bone resorption factor , the [cyclooxygenase-2] *induction* by was suppressed by dexamethasone with an IC ( 50 ) of 1 nM . Positive_regulation PTGS2 TNF 10631313 659775 We showed that the compound suppressed the *dependent* [cyclooxygenase-2] induction with an IC ( 50 ) of as low as about 30 nM as demonstrated experimentally by catalytic activity assay , Northern blot analysis and promoter analysis . Positive_regulation PTGS2 TNF 10718111 579354 A rapid increase in [PGHS-2] ( but not PGHS-1 ) mRNA expression was observed in *response* to and IL-1beta . Positive_regulation PTGS2 TNF 10785514 688320 and angiotensin II (Ang II) *induced* a transient increase in vascular smooth muscle cell ( VSMC ) [cyclooxygenase-2 (COX-2)] mRNA accumulation , without affecting COX-1 mRNA levels . Positive_regulation PTGS2 TNF 10810453 692772 In this study , we examined the *induction* of [COX-2] expression by interleukin-1 beta (IL-1 beta) and in human primary in vitro differentiated macrophages . Positive_regulation PTGS2 TNF 10866999 722319 An activator of peroxisome proliferator activated receptor gamma , 15-deoxy-Delta ( 12,14 ) -prostaglandin J ( 2 ) , also induces COX-2 expression and inhibits *induced* NFkappaB activation and [COX-2] expression . Positive_regulation PTGS2 TNF 10946303 722943 *induced* [cyclooxygenase-2] expression in human lung epithelial cells : involvement of the phospholipase C-gamma 2 , protein kinase C-alpha , tyrosine kinase , NF-kappa B-inducing kinase , and I-kappa B kinase 1/2 pathway . Positive_regulation PTGS2 TNF 10946303 722945 *induced* a dose- and time dependent increase in [cyclooxygenase-2 (COX-2)] expression and PGE2 formation in human NCI-H292 epithelial cells . Positive_regulation PTGS2 TNF 10946303 722946 Tyrosine kinase inhibitors ( genistein or herbimycin ) or phosphoinositide-specific phospholipase C inhibitor ( U73122 ) blocked *induced* [COX-2] expression . Positive_regulation PTGS2 TNF 10946303 722950 NF-kappaB DNA-protein binding and [COX-2] promoter activity were *enhanced* by , and these effects were inhibited by genistein , U73122 , staurosporine , or pyrolidine dithiocarbamate . Positive_regulation PTGS2 TNF 11162356 782136 Blockade NF-kappaB activation prohibits *induced* [cyclooxygenase-2] gene expression in ED27 trophoblast-like cells . Positive_regulation PTGS2 TNF 11252722 793974 We demonstrated that ROR alpha is expressed in human primary smooth-muscle cells and that ectopic expression of ROR alpha1 inhibits *induced* IL-6 , IL-8 and [COX-2] expression in these cells . Positive_regulation PTGS2 TNF 11266376 796722 Regulatory role of phosphatidylinositol 3-kinase on *induced* [cyclooxygenase 2] expression in colonic epithelial cells . Positive_regulation PTGS2 TNF 11266376 796732 In HT-29 and Caco-2 colonic epithelial cells , [COX-2] expression was *induced* by either or interleukin (IL)-1alpha as observed by Northern and Western analyses . Positive_regulation PTGS2 TNF 11356928 815785 *induces* [cyclooxygenase-2] expression and prostaglandin release in brain microvessel endothelial cells . Positive_regulation PTGS2 TNF 11356928 815787 Western blot analysis showed that had no apparent effect on the expression of COX-1 , but did *induce* the expression of [COX-2] in the BBMECs . Positive_regulation PTGS2 TNF 11412039 828239 We examined the effect of PPARalpha and PPARgamma ligands on untreated and *induced* [COX-2] expression in the human colorectal epithelial cell line HT-29 . Positive_regulation PTGS2 TNF 11412039 828242 , an inflammatory cytokine , *increased* [COX-2] expression via the NFkappaB pathway . Positive_regulation PTGS2 TNF 11412039 828243 Our results suggest that both PPARalpha signaling and signaling *increase* [COX-2] expression by independent pathways , while PPARgamma stimulates COX-2 expression by up-regulation of the TNF-alpha pathway . Positive_regulation PTGS2 TNF 11489969 845544 [Cyclooxygenase-2] expression and PGE2 release was *increased* by TPA and but not by HCMV infection . Positive_regulation PTGS2 TNF 11509550 848341 IL-1 beta and in combination also significantly *enhanced* [COX-2] promoter activity , indicating that synergism between the cytokines is mediated at the level of gene transcription . Positive_regulation PTGS2 TNF 11555578 859955 *induced* mPGES and [COX-2] in NSCLC cell lines but had no effect on the expression of either enzyme in a nontumorigenic bronchial epithelial cell line . Positive_regulation PTGS2 TNF 11556546 861078 Inhibitory action of nitric oxide on circulating *induced* NF-kappaB activity and [COX-2] transcription in the endothelium of the brain capillaries . Positive_regulation PTGS2 TNF 11556546 861081 This study investigated the hypothesis that nitric oxide ( NO ) acts as an endogenous modulator of *induced* NF-kappaB signaling and [COX-2] transcription in the endothelium of the cerebral capillaries . Positive_regulation PTGS2 TNF 11556546 861084 These results indicate that eNOS derived NO acts as an endogenous inhibitor of *induced* NF-kappaB activity and [COX-2] transcription in the endothelium of the cerebral capillaries . Positive_regulation PTGS2 TNF 11723253 884160 Conjugated polyhydroxybenzene derivatives block *mediated* nuclear factor-kappaB activation and [cyclooxygenase-2] gene transcription by targeting IkappaB kinase activity . Positive_regulation PTGS2 TNF 11723253 884175 These results suggest that the inhibitory effect of GF-015 and GF-90 on *induced* [COX-2] protein expression was caused by suppression of IKK activity and NF-kappaB activation in the COX-2 promoter , resulting in attenuation of COX-2 gene expression and PGE2 production . Positive_regulation PTGS2 TNF 11751489 889912 *induced* both mPGES and [COX-2] , but the time course and magnitude of induction differed . Positive_regulation PTGS2 TNF 12113550 963855 also *increased* [COX-2] mRNA levels . Positive_regulation PTGS2 TNF 12237848 989224 However , TGFbeta1 was ineffective in antagonizing the *induction* of [Cox-2] by either IL-6 or . Positive_regulation PTGS2 TNF 12349896 992860 Inhibition of *induced* [cyclooxygenase-2] expression by amentoflavone through suppression of NF-kappaB activation in A549 cells . Positive_regulation PTGS2 TNF 12349897 992863 In this paper , we investigated the involvement of NFkappaB on *mediated* prostaglandin E2 ( PGE2 ) release and [COX-2] gene expression in human gingival fibroblasts (HGF) . Positive_regulation PTGS2 TNF 12354747 993638 Both LPS and *induced* significant NFkappaB activation , [cyclooxygenase-2 (COX-2)] expression , and inducible NO synthase (iNOS) and cytokine production ; Positive_regulation PTGS2 TNF 12466023 1029251 In the murine neuroblastoma cell line NB-4 , which is characterized by constitutive NF-kappaB activity , [COX-2] promoter activity could not be further *increased* with PMA or . Positive_regulation PTGS2 TNF 12471036 1055484 Up-regulation of p300 binding and p50 acetylation in *induced* [cyclooxygenase-2] promoter activation . Positive_regulation PTGS2 TNF 12480916 1024257 In primary chondrocytes , *induced* expression of the antiapoptotic protein [Cox-2] , which persisted in the presence of SNP , and a specific Cox-2 inhibitor significantly blocked the TNF-alpha protective effect . Positive_regulation PTGS2 TNF 12576525 1058076 significantly *up-regulated* [COX-2] expression ( approximately 2-fold ) in differentiating 3T3-L1 cells , whereas similar effect was not observed with COX-1 expression . Positive_regulation PTGS2 TNF 12621554 1066423 Results showed that neither FK506 nor TP at lower concentration ( 10 microg/L ) alone affected *induced* [COX-2] , iNOS expression and production of PGE2 , NO in synovial cells . Positive_regulation PTGS2 TNF 12669881 1075932 In addition , both IL-1alpha and *up-regulated* [COX-2] protein expression by human pulp cells . Positive_regulation PTGS2 TNF 12707358 1082841 Tyrosine phosphorylation of I-kappa B kinase alpha/beta by protein kinase C-dependent c-Src activation is involved in *induced* [cyclooxygenase-2] expression . Positive_regulation PTGS2 TNF 12707358 1082846 The signaling pathway involved in *induced* [cyclooxygenase-2 (COX-2)] expression was further studied in human NCI-H292 epithelial cells . Positive_regulation PTGS2 TNF 12858113 1110802 Recent research shows a very promising role for new hormonal medication ( aromatase inhibitors , estrogen and progesterone receptor modulators ) and anti-inflammatory drugs ( inhibitors , matrix metalloproteinase inhibitors , [cyclooxygenase-2] *inhibitors* ) in the management of endometriosis . Positive_regulation PTGS2 TNF 12890694 1117657 The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates [COX-2] induction and PGE2 production in *response* to . Positive_regulation PTGS2 TNF 12890694 1117660 In a L929 fibroblast model , *induced* prostaglandin E2 ( PGE2 ) production by 4 h and [cyclooxygenase-2 (COX-2)] induction as early as 2 h . Positive_regulation PTGS2 TNF 12890694 1117663 Treatment of cells with RNAi to SK1 but not SK2 almost completely abolished the ability of to *induce* [COX-2] or generate PGE2 . Positive_regulation PTGS2 TNF 12892443 1117789 The results showed that lipopolysaccharide and tumor necrosis factor alpha , or TNF-alpha , induced COX-2 in macrophages , while IL-1beta and *induced* [COX-2] in oral epithelial cells . Positive_regulation PTGS2 TNF 12934647 1132837 Salicylate inhibited the IL-1beta and *induced* [COX-2] expressions , regulated the activation of ERK , IKK and IkappaB degradation , and the subsequent activation of NF-kappaB , in neonatal rat ventricular cardiomyocytes . Positive_regulation PTGS2 TNF 12934647 1132850 The inhibition of the ERK pathway , with a selective inhibitor , PD098059 , blocked the expressions of IL-1beta and *induced* [COX-2] and PGE2 release . Positive_regulation PTGS2 TNF 13679315 1185649 The overall results indicate that the stimulatory effect of on PGF2alpha production is *mediated* by the up-regulation of [COX-2] gene expression and suggest that one of the mechanisms of the inhibitory effect of IFNtau on luteolysis is the inhibition of TNFalpha action in PGF2alpha production in the stromal cells by the down-regulation of COX-2 gene expression stimulated by TNFalpha . Positive_regulation PTGS2 TNF 14584040 1187135 The catalytic Sec residue of TrxR1 , which is essential for reducing Trx , was required for this NF-kappa B activation , and aurothiomalate , an inhibitor of TrxR , suppressed *induced* activation of NF-kappa B and the expression of NF-kappa B-targeted proinflammatory genes such as E-selectin and [cyclooxygenase-2] . Positive_regulation PTGS2 TNF 14592548 1159953 *regulates* renal [COX-2] in the rat thick ascending limb (TAL) . Positive_regulation PTGS2 TNF 14630924 1201134 Flavopiridol also inhibited the expression of the *induced* NF-kappaB regulated gene products cyclin D1 , [cyclooxygenase-2] , and matrix metalloproteinase-9 . Positive_regulation PTGS2 TNF 14671209 1178368 However , *increased* both mPGES and [COX-2] protein expression in these cells . Positive_regulation PTGS2 TNF 14671209 1178369 In CT cells in culture , IL-1beta and *increased* both mPGES and [COX-2] protein levels . Positive_regulation PTGS2 TNF 14751545 1205474 markedly *increased* [COX-2] expression and PGE2 synthesis in a time- and concentration dependent manner , whereas COX-1 remained unaltered . Positive_regulation PTGS2 TNF 14751545 1205475 Tyrosine kinase inhibitor ( genistein ) , phosphatidylcholine-specific phospholipase C ( PC-PLC ) inhibitor ( D-609 ) and PKC inhibitor ( GF109203X ) attenuated *induced* [COX-2] expression and PGE2 synthesis in HTSMCs . Positive_regulation PTGS2 TNF 14751545 1205477 *induced* [COX-2] expression and PGE2 synthesis were also inhibited by PD98059 ( an inhibitor of MEK1/2 ) and SB203580 and SB202190 ( inhibitors of p38 MAPK ) , respectively , suggesting the involvement of p42/p44 and p38 MAPKs in these responses . Positive_regulation PTGS2 TNF 14751545 1205480 *induced* [COX-2] expression and PGE2 synthesis was also inhibited by NF-kappaB inhibitor pyrrolidinedithiocarbamate ( PDTC ) . Positive_regulation PTGS2 TNF 15063780 1230942 Studying the HT-29 colon cancer cell line as a model , we found that [Cox-2] expression and activity is *increased* approximately 25-fold by . Positive_regulation PTGS2 TNF 15067740 1232060 [ Effect of Triptolide on *induced* activation of NF-kappaB and expression of [COX-2] and iNOS in human rheumatoid arthritis synovial fibroblasts ] . Positive_regulation PTGS2 TNF 15067740 1232063 TP ( > 20 microg/L ) down-regulated markedly *induced* [COX-2] and iNOS mRNA and protein expression , and their inducing products PGE2 and NO of synovial fibroblasts . Positive_regulation PTGS2 TNF 15067740 1232065 TP could significantly down-regulate *induced* [COX-2] , iNOS expression and production of PGE2 , NO in human RASF , which is associated with the suppression of NF-kappaB activity . Positive_regulation PTGS2 TNF 15106733 1240556 Salicylate treatment inhibited [COX-2] expression *induced* by and regulated the activation of ERK , IKK and IkappaB degradation and subsequent NF-kappaB activation in MC3T3E1 osteoblasts . Positive_regulation PTGS2 TNF 15124245 1242464 Both IL-1beta and upregulated COX-2 mRNA comparably to IL-15 , but neither IL-2 nor interferon-g *had* any effect on the [COX-2] mRNA level . Positive_regulation PTGS2 TNF 15157676 1250593 Pretreatment with exogenous sphingomyelinase ( SMase ) dose-dependently enhanced *stimulated* increases in [COX-2] protein and sPLA ) activity . Positive_regulation PTGS2 TNF 15217903 1295643 In Matrigel assays , ICAM-1 and [COX-2] expressions *induced* by elicited A549 and NCI-H292 cell invasion , respectively , and these effects were inhibited by both compounds . Positive_regulation PTGS2 TNF 15229940 1269014 Upregulation of synoviocyte [COX-2] through interactions with T lymphocytes : *role* of interleukin 17 and . Positive_regulation PTGS2 TNF 15265936 1275726 The COX-2 promoter , which is regulated by NF-kappa B , was also inhibited by celecoxib , and this inhibition correlated with suppression of *induced* [COX-2] expression . Positive_regulation PTGS2 TNF 15266025 1275987 We also observed that , platelet activating factor (PAF) , and lipopolysaccharide (LPS) *induced* [COX-2] and increased MUC5AC production that was blocked by celecoxib , suggesting a common signaling pathway of inflammatory mediator induced MUC5AC production in NHTBE cells . Positive_regulation PTGS2 TNF 15389516 1354257 P(3)-25 inhibited *induced* [Cox2] expression . Positive_regulation PTGS2 TNF 15516323 1328542 ( 10ng/ml ) *increased* BSP , IL-6 and [COX-2] mRNA levels after 3h , reaching maximal levels at 12 h . Cbfa1 mRNA levels increased after 3 h , but decreased by 24 h. Osterix , cathepsin B , cathepsin L and TIMP-1 mRNA levels did not change after stimulation with TNF-alpha . Positive_regulation PTGS2 TNF 15621371 1358428 The addition of IL-1 receptor antagonist blocked the induction of COX-2 expression by IL-1beta , but did not alter *stimulated* increases in [COX-2] , indicating that the mechanism of TNFalpha is not limited to increasing the expression of IL-1beta . Positive_regulation PTGS2 TNF 15621371 1358429 The basal and *induced* expression of [COX-2] was not dependent on the presence of NGF in the growth media . Positive_regulation PTGS2 TNF 15642051 1363019 The cytokine *enhanced* the expression of mRNA as well as the protein levels of both [COX-2] and mPGES-1 and subsequently the production of PGE2 in gingival fibroblasts . Positive_regulation PTGS2 TNF 15649409 1363823 Two independent mechanisms of action were identified : ( 1 ) a drastic inhibition of the *induction* by of [cyclooxygenase 2 (COX-2)] protein expression and ( 2 ) a direct inhibition of COX enzyme activities with a significantly higher selectivity for COX-2 activity . Positive_regulation PTGS2 TNF 15649409 1363824 The inhibition of *dependent* induction of [COX-2] expression was mediated by an inhibition of NF-kappaB activation . Positive_regulation PTGS2 TNF 15664395 1365244 Diversity and similarity in signaling events leading to rapid [Cox-2] *induction* by and phorbol ester in human endothelial cells . Positive_regulation PTGS2 TNF 15664395 1365245 Conversely , MAPK p38 is critical for [Cox-2] *induction* by . Positive_regulation PTGS2 TNF 15665861 1365643 Increased [COX-2] activity *induced* by appears to be central to this process . Positive_regulation PTGS2 TNF 15713675 1395939 A nuclear run-on assay showed that *increased* [Cox-2] transcription , whereas butyrate was suppressive . Positive_regulation PTGS2 TNF 15843495 1445399 We observed that [COX2] expression and PGE2 production *induced* by were significantly abrogated by 15d-PGJ2 . Positive_regulation PTGS2 TNF 15851377 1399470 Neither FK506 nor TP at a lower concentration ( 10 ng/ml ) affected *induced* [COX-2] and iNOS expressions or PGE subset2 and NO productions in synovial cells . Positive_regulation PTGS2 TNF 15938622 1415430 Inhibition of NF-kappaB by cobrotoxin resulted in reductions in the LPS induced expressions of COX-2 , iNOS , cPLA(2) , IL-4 , and TNF-alpha in astrocytes and in [COX-2] expression *induced* by SNP , LPS , and in astrocytes . Positive_regulation PTGS2 TNF 16044148 1481803 is a potent *inducer* of [COX-2] expression in the ovarian surface epithelium and this regulation is a critical step in ovulation . Positive_regulation PTGS2 TNF 16044148 1481804 We observed that *stimulated* [COX-2] expression in human primary and immortalized epithelial ( HIO ) cell lines . Positive_regulation PTGS2 TNF 16044148 1481805 In NIH : OVCAR-5 , the only ovarian cancer cell line expressing COX-2 , signal pathway inhibitors no longer affected *induced* [COX-2] expression . Positive_regulation PTGS2 TNF 16358608 1492985 The Northern blot analysis showed that *stimulated* the expression of CCL2 and [COX-2] genes , and the synthesis of CCL2 messenger RNA was COX-2 dependent . Positive_regulation PTGS2 TNF 16448212 1521714 At a concentration of 50 mg/L PJ significantly suppressed *induced* [COX-2] protein expression by 79 % ( SE = 0.042 ) , total pomegranate tannin extract ( TPT ) 55 % ( SE = 0.049 ) , and punicalagin 48 % ( SE = 0.022 ) . Positive_regulation PTGS2 TNF 16457818 1522443 Western blot analysis and luciferase activity assay showed that anthocyanins inhibited *induced* vascular cell adhesion molecule-1 , intracellular adhesion molecule-1 , and [cyclooxygenase-2] levels , which is through NF-kappaB dependent pathway . Positive_regulation PTGS2 TNF 16473553 1574037 Furthermore , stimulation of B-CLL cells with CD40 ligand plus *increased* [Cox-2] levels . Positive_regulation PTGS2 TNF 16513308 1574352 TGF-beta , YJ ( 100microg/ml ) and their combinations of YJ+TGF-beta reduced the [COX-2] mRNA level , PGE2 biosynthesis and bone resorption *induced* by IL-1beta , , IL-6 or their combination . Positive_regulation PTGS2 TNF 16632868 1631286 Interleukin (IL) 1beta , or phorbol ester [ phorbol 12-myristate 13-acetate ( PMA ) ] *induced* the expression of [COX-2] , as revealed by western blot analysis . Positive_regulation PTGS2 TNF 16754782 1599083 also *increased* protein kinase A (PKA) expression and cAMP levels , [cyclooxygenase-2 (COX-2)] expression , and activated productions of prostaglandin ( PG ) E2 and 6-keto-PGF1alpha ( stable PGI2 metabolite ) . Positive_regulation PTGS2 TNF 16754782 1599084 Dexamethasone and N- [ 2- ( cyclohexyloxyl ) -4-nitrophenyl ] -methane sulfonamide ( NS-398 ; a selective COX-2 inhibitor ) attenuated *induced* expression of [COX-2] and activated productions PGE2 and PGI2 . Positive_regulation PTGS2 TNF 16803872 1585948 NFAT3 is specifically required for *induced* [cyclooxygenase-2 (COX-2)] expression and transformation of Cl41 cells . Positive_regulation PTGS2 TNF 16803872 1585950 The *induction* of [COX-2] by was abolished by knockdown of NFAT3 with its siRNA , while the induction of iNOS was not effected . Positive_regulation PTGS2 TNF 16816110 1580951 *induced* [COX-2] and mPGES-1 expression in neurons , followed by formation of PGE2 , which was blocked by a selective COX-2 inhibitor . Positive_regulation PTGS2 TNF 16816110 1580953 SC-560 treatment neither altered *induced* [COX-2] or mPGES-1 expression nor did the addition of the calcium ionophore A23187 or arachidonic acid reverse the inhibition by SC-560 . Positive_regulation PTGS2 TNF 17384033 1715809 Role of NF-kappaB in *induced* [COX-2] expression in synovial fibroblasts from human TMJ . Positive_regulation PTGS2 TNF 17384033 1715821 By reverse-transcriptase/polymerase chain-reaction ( RT-PCR ) and Western blotting analysis , *induced* a dose- and time dependent increase in [COX-2] expression . Positive_regulation PTGS2 TNF 17384033 1715826 These findings indicate that activation of NF-kappaB is responsible for *induced* [COX-2] expression in synovial fibroblasts from the TMJ . Positive_regulation PTGS2 TNF 17465224 1731909 Of the 13 berries tested , juice of 6 significantly inhibited the induced *activation* of [COX-2] expression and activation of the nuclear transcription factor NFkappaB . Positive_regulation PTGS2 TNF 17481552 1738700 In this review , we provide evidence for reduced [COX-2] transcriptional expression in *response* to phorbol esters ( PMA ) , lipopolysaccharide (LPS) , interleukin-1beta (IL-1beta) and . Positive_regulation PTGS2 TNF 17611628 1768635 In vitro , luteolin sensitized colonic epithelial HT29 cells to TNFalpha induced apoptosis , caspase 3 activation , DNA fragmentation and reduced *induced* C-IAP1 , C-IAP2 and [COX-2] gene expression . Positive_regulation PTGS2 TNF 17708399 1783070 In vitro , , IL-6 , and EGF *increased* [COX-2] expression in nonneoplastic cells but not in PCA cells , where baseline expression was high . Positive_regulation PTGS2 TNF 17763959 1866099 Ghrelin caused a decrease in *induced* [COX-2] and IL-1beta expression in OE-19 cells . Positive_regulation PTGS2 TNF 17942934 1814226 The *induction* of various antiapoptotic gene products ( MMP-9 , cyclin D1 , [COX-2] , IAP1 , IAP2 , Bcl-2 , cFLIP , and XIAP ) by was also abolished in NQO2-/- cells . Positive_regulation PTGS2 TNF 18187550 1883645 furthermore strongly *enhanced* expression and/or synthesis of other inflammatory molecules , namely IL-6 and [cyclooxygenase-2] . Positive_regulation PTGS2 TNF 18803934 1965117 The p38 MAPK inhibitor SB203580 blocked *mediated* induction of [COX-2] protein expression , suggesting a regulatory mechanism through p38 MAPK signaling . Positive_regulation PTGS2 TNF 18815359 2012419 thus implicating for the first time SK1 in mediated [COX-2] *induction* in vivo . Positive_regulation PTGS2 TNF 19140872 2025658 Inhibition of *induced* [cyclooxygenase-2] expression by Mycobacterium bovis BCG in human alveolar epithelial A549 cells . Positive_regulation PTGS2 TNF 19140872 2025659 Our results demonstrates that Mycobacterium bovis BCG ( M. bovis BCG ) downregulates *induced* [COX-2] gene expression in alveolar epithelial cells by inhibiting the phosphorylations of Raf-1 and p38 kinases . Positive_regulation PTGS2 TNF 19174152 2043630 Fyn kinase is a direct molecular target of delphinidin for the inhibition of [cyclooxygenase-2] expression *induced* by . Positive_regulation PTGS2 TNF 19174152 2043631 Here we report that Fyn kinase - one of the members of the nonreceptor protein tyrosine kinase family - is involved in *induced* [COX-2] expression , and that delphinidin - a major anthocyanidin present in red wine and berries - inhibits these effects by directly inhibiting Fyn kinase activity . Positive_regulation PTGS2 TNF 19174152 2043632 Delphinidin strongly inhibited *induced* [COX-2] expression in JB6 P+ mouse epidermal ( JB6 P+ ) cells , whereas two other major phenolic compounds ( resveratrol and gallic acid ) did not exert significant inhibitory effects . Positive_regulation PTGS2 TNF 19174152 2043633 By using PP2 ( a commercial inhibitor of Fyn kinase ) and siRNA-Fyn , we confirmed that Fyn kinase is involved in *induced* [COX-2] expression mainly by down regulating JNK in JB6 P+ cells . Positive_regulation PTGS2 TNF 19197941 2044082 [COX-2] expression and PGE ( 2 ) production by MSC were not constitutive , but were *induced* by IFN-gamma and secreted by activated Vgamma9Vdelta2 T cells . Positive_regulation PTGS2 TNF 19218340 2039517 The 1 (TNF-R1) interaction *induced* MMP-9 production and activation , as well as [COX-2] overexpression and PGE2 production , and increased the migration of CC cells . Positive_regulation PTGS2 TNF 19218340 2039522 In conclusion , we propose a novel signaling pathway of MMP-9 up-regulation in CC cells such that *induces* the activation of [COX-2] and PGE2 via TNF-R1 followed by the up-regulation of MMP-9 via the PGE2 ( EP2/4 ) receptor . Positive_regulation PTGS2 TNF 19415240 2089858 Furthermore , OGD and the NF-kappaB activator *stimulated* the expression of cPLA-2 , [cyclooxygenase-2 (COX-2)] , and mPGES-1 and increased the release of PGE ( 2 ) from neurons . Positive_regulation PTGS2 TNF 19801900 2148236 Furthermore , vaspin did not decrease the ( 24 hr ) *induction* of vascular cell adhesion molecule-1 , intercellular adhesion molecule-1 , endothelial selectin , and [cyclooxygenase-2] protein expression as well as monocyte chemotactic protein-1 , tissue factor , and plasmogen activator inhibitor-1 mRNA expression . Positive_regulation PTGS2 TNF 20116443 2258836 IL1beta , and LPS *enhanced* the expression of [COX-2] and mPGES1 whereas phorbol ester enhanced COX-2 expression only . Positive_regulation PTGS2 TNF 20307736 2230577 Stimulation with and IL-1alpha synergistically *increased* levels of [COX-2] as well as RANKL mRNA and protein expression . Positive_regulation PTGS2 TNF 20585313 2320396 in contrast , ErbB4 knockdown with siRNA blocked [COX-2] accumulation in *response* to . Positive_regulation PTGS2 TNF 20616214 2321733 *stimulated* [PTGS2] and mPGES-1 mRNA , as well as mPGES-1 protein expression and PGE ( 2 ) release on days 11-12 of pregnancy and the estrous cycle . Positive_regulation PTGS2 TNF 20631885 2292016 *induced* the expression of [COX-2] in A549 cells , but did not induce BEAS-2B expression . Positive_regulation PTGS2 TNF 20631885 2292017 The adenoviral transfection of cells with AdRef-1 inhibited *induced* [COX-2] expression relative to that seen in the control cells ( Adbetagal ) . Positive_regulation PTGS2 TNF 20631885 2292018 Pretreatment with 10 microM of SB203580 suppressed *induced* [COX-2] expression , thereby suggesting that p38 MAPK might be involved in COX-2 expression in A549 cells . Positive_regulation PTGS2 TNF 20677482 2181656 *induced* [cyclooxygenase-2] overexpression in eutopic endometrium of women with endometriosis by stromal cell culture through nuclear factor-kappaB activation . Positive_regulation PTGS2 TNF 20677482 2181657 To investigate the role of NF-kappaB during the *induction* of [COX-2] by in the eutopic endometrium of women with and without endometriosis using stromal cell culture . Positive_regulation PTGS2 TNF 21075851 2376682 Interestingly , we found that activation of E-prostanoid (EP)2 and EP4 receptors , but not EP1 , EP3 , PGI(2) receptor ( IP ) , thromboxane A(2) receptor ( TP ) , PGD(2) receptor ( DP ) , and PGF ( 2 ) receptor ( FP ) , efficiently blocked LPS induced synthesis and [COX-2] and mPGES-1 *induction* as well as prostaglandin synthesis in spinal cultures . Positive_regulation PTGS2 TNF 21116687 2389940 This PRL concentration ( comparable to plasma PRL levels in lactation ) also *induced* the upregulation of monocyte chemoattractant protein (MCP)-1 , [cyclooxygenase (Cox)-2] , and ephrin-B1 , whereas a higher concentration ( 500 ng/ml ) was required to upregulate and interleukin (IL)-1 . Positive_regulation PTGS2 TNF 21417548 2463517 Furthermore , IL-1ß , , and IL-6 also *induced* [COX2] expression . Positive_regulation PTGS2 TNF 21417802 2499760 A significant increase in IL-6 , reactive oxygen species ( ROS ) generation , nuclear translocation of nuclear factor-kappa B ( NF-?B ) , *induction* of [cyclooxygenase-2 (COX-2)] , and ( TNF-a ) expression was observed in macrophages with maximum response found in cells exposed to Ag NPs followed by Al , CB and CAg . Positive_regulation PTGS2 TNF 21435451 2406392 In *response* to ( TNF-a ) , IL-1ß , and cocultured lymphocytes , however , mPGES-1 and [COX-2] protein expression increased in fibroblasts and smooth muscle cells , accompanied by increased PGE ( 2 ) , whereas mPGES-2 and cPGES were unaffected . Positive_regulation PTGS2 TNF 21514279 2423002 An inhibitor of JNK significantly inhibited the *induced* [COX-2] expression . Positive_regulation PTGS2 TNF 21514279 2423003 Inhibitory effect of omentin on *induced* [COX-2] was reversed by a NOS inhibitor . Positive_regulation PTGS2 TNF 21514279 2423005 The present results demonstrate for the first time that omentin plays an anti-inflammatory role by preventing the *induced* [COX-2] expression in vascular endothelial cells . Positive_regulation PTGS2 TNF 21566012 2458885 transactivation of EGFR *stimulates* cytoprotective [COX-2] expression in gastrointestinal epithelial cells . Positive_regulation PTGS2 TNF 21566012 2458890 *induced* [COX-2] expression was reduced and absent in EGFR ( -/- ) and TNF receptor-1 (TNFR1) knockout MCE cells , respectively , but was restored upon expression of the WT receptors . Positive_regulation PTGS2 TNF 21626431 2454638 Indeed , levosimendan increased cyclic guanosine monophosphate ( cGMP ) in human umbilical vein endothelial cells ( HUVECs ) and impaired the *induced* inflammatory expression of E-selectin , intercellular adhesion molecule-1 ( ICAM-1 ) , [cyclooxygenase-2 (COX-2)] , and monocyte chemotactic protein-1 (MCP-1) . Positive_regulation PTGS2 TNF 21705614 2465715 Luteolin , a novel natural inhibitor of tumor progression locus 2 serine/threonine kinase , inhibits *induced* [cyclooxygenase-2] expression in JB6 mouse epidermis cells . Positive_regulation PTGS2 TNF 21705614 2465723 In the present study , we found that luteolin inhibited *induced* [COX-2] expression by down regulating the transactivation of nuclear factor-?B and activator protein-1 . Positive_regulation PTGS2 TNF 21705614 2465731 These effects of luteolin on *mediated* signaling pathways and [COX-2] expression are similar to those achieved by blocking tumor progression locus 2 serine/threonine kinase ( TPL2 ) using pharmacologic inhibitors and small interfering RNAs . Positive_regulation PTGS2 TNF 21820422 2490444 Triptolide also abrogated *induced* expression of cell survival proteins ( XIAP , Bcl-x ( L ) , Bcl-2 , survivin , cIAP-1 and cIAP-2 ) , cell proliferative proteins ( cyclin D1 , c-myc and [cyclooxygenase-2] ) , and metastasis proteins ( ICAM-1 and MMP-9 ) . Positive_regulation PTGS2 TNF 21968252 2502806 Pretreatment of EECs with PDTC resulted in a dose dependent reduction in the *induced* expressions of [COX-2] at gene and protein levels , as well as a reduction of PGE ( 2 ) synthesis . Positive_regulation PTGS2 TNF 22093832 2514223 In the present study , the effects of triptolide on COX-2 expression in A549 cells were investigated and triptolide was found to inhibit *induced* [COX-2] expression . Positive_regulation PTGS2 TNF 22101002 2629377 The colocalization of calcium sensing receptor (CaR) and COX-2 in the TAL supports the notion that activation of CaR induces *dependent* [COX-2] expression and PGE2 synthesis in mTAL cells . Positive_regulation PTGS2 TNF 22235849 2591903 TLR agonists and *induce* transcriptional and translational expression of [COX-2] in vaginal cells . Positive_regulation PTGS2 TNF 22267101 2564860 Cinobufocini inhibits NF-?B and [COX-2] activation *induced* by in lung adenocarcinoma cells . Positive_regulation PTGS2 TNF 22510965 2584226 We also demonstrated that pretreatment of cells with this compound prevented *induced* expression of NF-?B target genes , such as interleukin 6 , interleukin 8 , monocyte chemotactic protein 1 , [cyclooxygenase-2] and inducible nitric oxide . Positive_regulation PTGS2 TNF 22608768 2681543 Lipopolysaccharides , , IL-1a , and the reagents combination *increased* [PTGS2] , PTGES , and PGFS mRNA transcription ( P < 0.01 ) , whereas ALOX5 mRNA transcription was increased only by TNF ( P < 0.001 ) . Positive_regulation PTGS2 TNF 22704420 2616009 FYN significantly inhibited *induced* expression of iNOS and [COX-2] compared with the control group in A549 cells ( P < 0.01 , P < 0.01 ) . Positive_regulation PTGS2 TNF 22704420 2616014 These results suggest that FYN inhibits iNOS and [COX-2] activation *induced* by , therefore , it is expected to develop a new strategy to treat lung cancer . Positive_regulation PTGS2 TNF 22800939 2645768 *induces* renal [cyclooxygenase-2] expression in response to hypercalcemia . Positive_regulation PTGS2 TNF 22821773 2682269 According to Western blot analysis and a luciferase activity assay , anthocyanins inhibited *induced* intercellular adhesion molecule-1 and [cyclooxygenase-2 (COX-2)] levels through the NF-?B dependent pathway . Positive_regulation PTGS2 TNF 23257246 2737295 Resveratrol dose-dependently inhibited *induced* [cyclooxygenase-2 (COX-2)] , MMP-1 , MMP-3 , MMP-13 and PGE ( 2 ) production in human chondrocytes . Positive_regulation PTGS2 TNF 23717114 2714412 Furthermore , the ginsenosides Rd and Km inhibited the *induced* expression levels of the [COX-2] and iNOS gene in HepG2 cells . Positive_regulation PTGS2 TNF 23756390 2797853 TNF-a increased the expression of COX-2 , iNOS and inflammatory cytokines , but GS-HCl significantly attenuated *induced* [COX-2] expression . Positive_regulation PTGS2 TNF 23843954 2816525 Carvedilol decrease IL-1ß and , *inhibits* MMP-2 , MMP-9 , [COX-2] , and RANKL expression , and up-regulates OPG in a rat model of periodontitis . Positive_regulation PTGS2 TNF 23868940 2825318 NOD2 induced [cyclooxygenase-2] expression in macrophages was dependent on p38 mitogen activated protein kinase activation and was *mediated* by interleukin-1ß and . Positive_regulation PTGS2 TNF 24133591 2853388 Among four kinds of cytokines , IL-1ß treatment increased COX-2 protein expression and VEGF release in three ESC , and *had* the same effect on [COX-2] protein level as IL-1ß only in ectopic and eutopic ESC , and MCSF had only slight effect on ectopic ESC . Positive_regulation PTGS2 TNF 7582449 333533 These results suggest that ( i ) the induction of COX activity and [COX-2] protein elicited by LPS in BAEC is *mediated* by with lesser contributions from PDGF , EGF or IL-1 beta ; Positive_regulation PTGS2 TNF 7582449 333536 ( ii ) exogenous IL-1 beta , or EGF alone *induce* [COX-2] activity and protein in BAEC ; Positive_regulation PTGS2 TNF 8537402 338618 Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the alpha dependent *induction* of [cyclooxygenase-2] in MC3T3-E1 cells . Positive_regulation PTGS2 TNF 8537402 338625 These data suggested a potential role of both NF-IL6 and NF kappa B in the *induction* of [cyclooxygenase-2] by . Positive_regulation PTGS2 TNF 8654401 358801 Northern blot analysis showed that and IL-1beta *increased* both PLA2 and inducible cyclooxygenase ( [Cox-2] ) mRNA transcription . Positive_regulation PTGS2 TNF 8852946 387876 IL-1 and , both at 1-100 ng/ml , and PTH at 0.1-10 nM *increased* [PGHS-2] and cPLA2 mRNA and medium PGE2 levels dose-dependently after 4 h of treatment . Positive_regulation PTGS2 TNF 8852946 387886 We conclude that ( 1 ) IL-1 , , and PTH , but not IL-6 nor IL-11 , can *increase* the expression of [PGHS-2] , cPLA2 , and PGE2 production in cultured mouse calvariae ; Positive_regulation PTGS2 TNF 9093911 422207 Both TGF beta and could independently *increase* [COX-2] mRNA levels and PG biosynthesis . Positive_regulation PTGS2 TNF 9138698 424225 IL-1 beta and *increased* [COX-2] activity and an additional small increase was produced by the three cytokines in combination . Positive_regulation PTGS2 TNF 9144511 429630 However , suppression of PGHS-2 expression is not the result of suppressed cytokine production , because SK & F 86002 suppressed [PGHS-2] expression *initiated* by IL-1beta and , in addition to other stimuli . Positive_regulation PTGS2 TNF 9405225 469731 Supplementing HMC with the BH4 donor sepiapterin potentiated *induced* [COX-2] expression by approximately 2-fold . Positive_regulation PTGS2 TNF 9440135 475091 *promotes* sustained [cyclooxygenase-2] expression : attenuation by dexamethasone and NSAIDs . Positive_regulation PTGS2 TNF 9440135 475092 *stimulated* [COX-2] expression and the subsequent formation of PGE2 were inhibited by dexamethasone ( 0.1 microM ) . Positive_regulation PTGS2 TNF 9570560 501594 [COX-2] was also induced , or its expression was *increased* , by , IL-1 , and IL-8 . Positive_regulation PTGS2 TNF 9576062 502804 *mediated* regulation of [prostaglandin endoperoxide synthase-2] ( PGHS-2 ) mRNA levels was examined in murine fibrosarcoma MCA-101 cells . Positive_regulation PTGS2 TNF 9576062 502806 TNF-alpha induced PGE2 production was evident after 12 h and was associated with a significant *mediated* increase in [PGHS-2] immunoreactive protein . Positive_regulation PTGS2 TNF 9576062 502807 Inhibition of protein tyrosine phosphatases (PTPs) and protein tyrosine kinases ( PTKs ) inhibited the *mediated* increase in [PGHS-2] mRNA levels . Positive_regulation PTGS2 TNF 9580637 504971 These data demonstrate that tyrosine kinase pathways are not required for TNF-alpha induced NF-kappa B activation in MCA-101 cells and suggest that signaling via these pathways mediates *induced* [PGHS-2] mRNA accumulation via an NF-kappa B-independent mechanism . Positive_regulation PTGS2 TNF 9622592 511269 [Cox-2] mRNA expression was markedly *enhanced* by and suppressed by all growth factors tested . Positive_regulation PTGS2 TNF 9632078 512590 IL-1alpha and *increased* the expression of [COX-2] . Positive_regulation PTGS2 TNF 9633531 513132 In vitro transcription assays showed that IL-1 beta and *increased* the transcription of the [Cox-2] gene , whereas TGF-beta 1 had no effect . Positive_regulation PTGS2 TNF 9633531 513134 In summary , we demonstrate that the potentiation of PGE2 production by TGF-beta 1 in IL-1 beta and TNF-alpha treated fibroblasts is the result of transcriptional *stimulation* of the [Cox-2] gene by IL-1 beta and and the stabilization of the resulting transcripts by TGF-beta 1 . Positive_regulation PTGS2 TNF 9722548 528971 *Induction* of [COX-2] and stimulation of COX activity by ET-1 and were prevented by sodium salicylate and MG-132 , suggesting that activation of NF-kappaB by either factor is needed for stimulation of COX-2 . Positive_regulation PTGS2 TNF 9737714 531582 A number of agents , including PMA , opsonized bacteria and zymosan , LPS , GM-CSF , , and fMLP , *induced* [COX-2] protein expression through signaling pathways involving transcription and protein synthesis events . Positive_regulation PTGS2 TNF 9815044 546499 These results indicate that COX-2 protein is highly localized in the base of gastric ulcers in rats and that [COX-2] mRNA expression might be *regulated* positively by IL-1beta and and negatively by TGF-beta1 . Positive_regulation PTGS2 TNF 9893042 558653 We used an adenoviral vector containing an NF-kappaB super-repressor ( Ad5IkappaB ) to investigate the role of NF-kappaB in *mediated* [COX-2] gene expression in a colonic epithelial cell line . Positive_regulation PTGS2 TNFSF10 21195543 2379076 Furthermore , we showed that diosgenin alone , alone or combination treatment *increased* [COX-2] expression and that the use of a COX-2 inhibitor further increased apoptosis induction . Positive_regulation PTH ADAMTS1 11108265 756815 We also analyzed the regulation of ADAMTS-1 in response to various PTH/PTH related peptide (PTHrP) analogs and found that [PTH-] ( 1-31 ) and PTHrP- ( 1-34 ) , which activate the protein kinase A (PKA) pathway , *induce* expression 1 h after injection , whereas PTH- ( 3-34 ) and PTH- ( 7-34 ) , which do not activate the PKA pathway , did not regulate expression . Positive_regulation PTH ADAMTS1 17560840 1767658 The multi-domain neutral endopeptidase , ( a disintegrin and metalloprotease with thrombospondin repeats ) is *induced* by [parathyroid hormone (PTH)] in rat osteoblasts and has therefore been suggested to be involved in initiation of bone remodeling . Positive_regulation PTH ADAMTS1 22002813 2591666 Along these lines , *increased* blood levels of [PTH] only in females whereas it reduced osteocalcin levels only in males . Positive_regulation PTH CA12 3145673 102022 The transient increase in acidity may be due to *activation* of by [PTH] . Positive_regulation PTH CCND1 17501623 1761802 These data indicate that [PTH] and PTHrP *induce* expression in early osteoblastic cells and their action is developmental stage specific . Positive_regulation PTH EPHB2 11089552 751261 We examined [PTH] *activation* of the mitogen activated protein kinase (MAPK) cascade in PCT and DCT cells and its effects on calcium transport and signaling . Positive_regulation PTH EPHB2 23197743 2745427 We conclude that [PTH] regulation of osteoblast mineralization in female mice is maturation stage specific and *involves* MKP1 modulation of and P-p38 MAPKs . Positive_regulation PTH ITGB2 12402981 1009562 In a coculture system of murine spleen cells and osteoblasts , the interaction was also *involved* in 1,25D- , [PTH-] and IL-1alpha stimulated TRAP positive MNC formation . Positive_regulation PTH MAP2K6 11089552 751267 We examined [PTH] *activation* of the mitogen activated protein kinase (MAPK) cascade in PCT and DCT cells and its effects on calcium transport and signaling . Positive_regulation PTH RGS2 11996904 939162 [Parathyroid hormone] *induces* expression by a cyclic adenosine 3',5'-monophosphate mediated pathway in primary neonatal murine osteoblasts . Positive_regulation PTH RGS2 19225708 2050389 [PTH] *induces* , a member of the Regulator of G-protein Signaling protein family , via cAMP/PKA , and inactivates PKC mediated signaling . Positive_regulation PTH TNF 10379905 623940 IL-6 and *had* no acute effect on [PTH] secretion in extracellular Ca2+ concentrations of 0.5 , 1.25 and 3.0 mM . Positive_regulation PTH TNF 14664720 1177713 *had* no effect on PTH secretion , and [PTH] and CaR mRNA expression . Positive_regulation PTH TNF 20808842 2314348 These findings demonstrate that PPR signaling in T cells *plays* an essential role in [PTH] induced bone loss by promoting T cell production of . Positive_regulation PTH TNF 8852946 387879 IL-1 and , both at 1-100 ng/ml , and [PTH] at 0.1-10 nM *increased* PGHS-2 and cPLA2 mRNA and medium PGE2 levels dose-dependently after 4 h of treatment . Positive_regulation PTH1R EPHB2 17107942 1700428 We conclude that phosphorylation in distal kidney cells by PTH *requires* [PTH1R] activation of G ( i ) , which leads to stimulation of metalloprotease mediated cleavage of HB-EGF and transactivation of the EGFR and is regulated by EBP50 . Positive_regulation PTH1R EPHB2 20578167 2367895 Signaling and *activation* of cAMP and by [?e14-PTHR] was decreased significantly compared with PTHR . Positive_regulation PTH1R MAP2K6 12606410 1064530 The nitric oxide mediated increase of [P-Thr-Glu-Tyr-P] *involved* protein Tyr kinase , or MEK-like kinase , and protein kinase C but not protein kinase A . Positive_regulation PTH1R ZFP57 21642473 2470672 Our results show that expression is up-regulated in Jansen mouse growth plate chondrocytes and that [PTHR1] is *required* for Zfp521 expression . Positive_regulation PTHLH ADAMTS1 11108265 756816 We also analyzed the regulation of ADAMTS-1 in response to various PTH/PTH related peptide (PTHrP) analogs and found that PTH- ( 1-31 ) and [PTHrP-] ( 1-34 ) , which activate the protein kinase A (PKA) pathway , *induce* expression 1 h after injection , whereas PTH- ( 3-34 ) and PTH- ( 7-34 ) , which do not activate the PKA pathway , did not regulate expression . Positive_regulation PTHLH CCND1 17501623 1761798 [PTHrP] *induced* a proliferative activation in low-density osteoblastic cells . Positive_regulation PTHLH CCND1 17501623 1761803 These data indicate that PTH and [PTHrP] *induce* expression in early osteoblastic cells and their action is developmental stage specific . Positive_regulation PTHLH CCND1 23824099 2854235 Exogenous [PTHrP] *induced* the expression of and Bcl-2 mRNA by various signalling pathways , whereas it inhibited Runx2 expression through PKA , p38MAPK , MEK and PI3K signalling pathways . Positive_regulation PTHLH CTGF 16813525 1580695 Furthermore , we found that was *induced* by [PTHrP] through PKA- , PKC- , and ERK mediated pathways therein . Positive_regulation PTHLH CTGF 16813525 1580725 was critically involved in osteolytic metastasis and was *induced* by PKA- and PKC dependent activation of ERK1/2 signaling by [PTHrP] . Positive_regulation PTHLH EPHB2 17426287 1742286 Interestingly , this Rab11a dominant negative mutant does not interfere with CaR dependent activation of ERK 1/2 , suggesting that signaling is not *sufficient* to promote [PTHrP] secretion downstream of CaR . Positive_regulation PTHLH GPR115 15515174 1343031 *Activation* of this by [PTHrP] has been shown to regulate chondrogenesis in a manner that attenuates chondrocyte hypertrophy . Positive_regulation PTHLH GPR132 15515174 1343020 *Activation* of this by [PTHrP] has been shown to regulate chondrogenesis in a manner that attenuates chondrocyte hypertrophy . Positive_regulation PTHLH GPR87 15515174 1343100 *Activation* of this by [PTHrP] has been shown to regulate chondrogenesis in a manner that attenuates chondrocyte hypertrophy . Positive_regulation PTHLH IL1B 10773106 686362 *upregulates* [PTHrP-mRNA] expression and protein production and decreases TGF-beta in normal human osteoblast-like cells . Positive_regulation PTHLH IL1B 10773106 686363 Using a quantitative PCR-assay following reverse transcription of RNA , in situ hybridization , and a two-site immunofluorometric assay for PTHrP , we demonstrate that in a dose- and time dependent manner *increases* [PTHrP-mRNA] expression and PTHrP-protein secretion . Positive_regulation PTHLH IL1B 11011119 752639 TNF-alpha or *induced* both G-CSF and [PTHrP] production in the conditioned medium . Positive_regulation PTHLH IL1B 8227368 235659 Murine TNF-alpha and human , cytokines that mediate many of the effects of LPS , also *increased* splenic [PTHrP] mRNA levels . Positive_regulation PTHLH IL1B 8227368 235661 LPS-resistant C3H/HeJ mice , which produce minimal amounts of TNF and IL-1 in response to LPS , were resistant to LPS induction of splenic PTHrP mRNA , while TNF-alpha and readily *increased* [PTHrP] mRNA levels in C3H/HeJ mice . Positive_regulation PTHLH IL1B 9525978 495947 TNF-alpha and *stimulated* [PTHrP] expression in synoviocytes , while dexamethasone and interferon-gamma , agents with some therapeutic efficacy in the treatment of RA , inhibited PTHrP release . Positive_regulation PTHLH JAG1 19587161 2105241 These results demonstrate that [PTHrP] *induces* expression in PDL cells , leading to osteo- and odontoclastogenesis , and thus likely promoting tooth and alveolar bone resorption . Positive_regulation PTHLH TNF 11011119 752638 or IL-1beta *induced* both G-CSF and [PTHrP] production in the conditioned medium . Positive_regulation PTHLH TNF 11595209 870118 To determine whether [PTHrP] was *induced* in glia by , a known mediator of inflammation in brain and of PTHrP induction in peripheral tissues , and to determine whether PTHrP , in turn , mediated inflammatory changes in glia , in vitro studies with rat astrocytes and glial enriched mixed brain cells were also undertaken . Positive_regulation PTHLH TNF 11595209 870120 *induced* [PTHrP] expression in astrocyte and glial enriched brain cells in vitro , suggesting that this pro-inflammatory peptide was a possible mediator of PTHrP expression in CNS inflammation . Positive_regulation PTHLH TNF 7829996 285831 *caused* a 1.9 +/- 0.1-fold increase in immunoreactive [PTHrP] production , which was maximal by 24 h of incubation . Positive_regulation PTHLH TNF 8227368 235658 Murine and human IL-1 beta , cytokines that mediate many of the effects of LPS , also *increased* splenic [PTHrP] mRNA levels . Positive_regulation PTHLH TNF 8227368 235660 LPS-resistant C3H/HeJ mice , which produce minimal amounts of TNF and IL-1 in response to LPS , were resistant to LPS induction of splenic PTHrP mRNA , while and IL-1 beta readily *increased* [PTHrP] mRNA levels in C3H/HeJ mice . Positive_regulation PTHLH TNF 9525978 495946 and IL-1beta *stimulated* [PTHrP] expression in synoviocytes , while dexamethasone and interferon-gamma , agents with some therapeutic efficacy in the treatment of RA , inhibited PTHrP release . Positive_regulation PTK2 ANGPT1 10807867 692373 *induced* tyrosine phosphorylation of [p125(FAK)] , and this phosphorylation was dependent on phosphatidylinositol (PI) 3'-kinase activity . Positive_regulation PTK2 CAPN8 10545505 564600 Thus , collagen fragments induce distinct integrin signals that lead to initiation of *mediated* cleavage of [pp125(FAK)] , paxillin , and talin and dissolution of the focal adhesion complex . Positive_regulation PTK2 CAPN8 22721990 2626949 This effect is elicited through reorganization of the cytoskeleton and focal adhesion , activation of RhoA and Rac1 , and *mediated* cleavage of [pp125(FAK)] . Positive_regulation PTK2 EDN2 10402223 628918 *stimulates* tyrosine phosphorylation of [p125FAK] and p130Cas in rat cerebral cortex . Positive_regulation PTK2 EDN2 8631827 357209 In contrast , tyrosine phosphorylation of [p125FAK] and paxillin in *response* to bombesin , , and phorbol 12,13-dibutyrate was not inhibited by wortmannin in these cells . Positive_regulation PTK2 EPHB2 12774925 1095319 We found that Lyn [protein tyrosine kinase] was constitutively phosphorylated on tyrosine , and that and p38 MAPK were constitutively *active* in all cases of the B-cell tumor . Positive_regulation PTK2 EPHB2 15797477 1390351 Moreover , the ConA induced IFN-gamma mRNA expression was partly prevented by genistein , a global [PTK] *inhibitor* , and PD-98059 , an inhibitor , respectively . Positive_regulation PTK2 IL1B 7519214 265515 The results suggest that TNF-alpha and secretion after LPS stimulation of human monocytes *requires* the activation of [protein tyrosine kinase] and PKC , upstream to the activation of gene transcription . Positive_regulation PTK2 IL1B 9230816 444770 Modulation of and TNF-alpha receptors by VLA-5 and VLA-6 *required* [protein tyrosine kinase] activation as herbimycin A ( 10 micrograms/mL ) blocked the affect of Fn and Ln . Positive_regulation PTK2 ITGAL 10863474 580425 Beta 2-integrin , *mediated* [p125FAK] activation . Positive_regulation PTK2 PECAM1 22000807 2503094 Syk [protein tyrosine kinase] *involves* signaling through tandem immunotyrosine inhibitory motifs in human THP-1 macrophages . Positive_regulation PTK2 STK39 23335513 2753483 Thrombin mediated proteoglycan synthesis utilizes both [protein-tyrosine kinase] and receptor *transactivation* in vascular smooth muscle cells . Positive_regulation PTK2 STK39 23335513 2753573 In contrast , serine/threonine kinase receptor transactivation is mediated by a cytoskeletal rearrangement-Rho kinase-integrin system , and both [protein-tyrosine kinase] and receptor *transactivation* concomitantly account for the total proteoglycan synthesis stimulated by thrombin in vascular smooth muscle . Positive_regulation PTK2 TNF 15240695 1270291 *activates* Syk [protein tyrosine kinase] leading to TNF induced MAPK activation , NF-kappaB activation , and apoptosis . Positive_regulation PTK2 TNF 7541425 310486 Inhibitors of [protein tyrosine kinase] suppress stimulated *induction* of endothelial cell adhesion molecules . Positive_regulation PTK2 TNF 7675795 326320 These findings suggest that , in TNF-resistant cells , *activates* a [protein tyrosine kinase] that contributes to the cell 's resistance to lysis and this resistance mechanism does not function in the TNF-sensitive cell line . Positive_regulation PTK2 TNF 8766564 374999 LPS induced and IL-10 expression *requires* early activation of [protein tyrosine kinases (PTK)] . Positive_regulation PTK2 TNF 9230816 444769 Modulation of IL-1 beta and receptors by VLA-5 and VLA-6 *required* [protein tyrosine kinase] activation as herbimycin A ( 10 micrograms/mL ) blocked the affect of Fn and Ln . Positive_regulation PTK2B ITGB2 10359604 619410 Furthermore , the interaction of the activated integrin with its ligand intercellular adhesion molecule 1 *induced* the activation of the cytoplasmic tyrosine kinases focal adhesion kinase ( FAK ) and [proline-rich tyrosine kinase 2 (PYK-2)] . Positive_regulation PTK2B TNF 10597281 573594 [Related Adhesion Focal Tyrosine Kinase] ( RAFTK ; also known as Pyk2 ) , is a member of the Focal Adhesion Kinase ( FAK ) subfamily and is *activated* by , UV light and increases in intracellular calcium levels . Positive_regulation PTK2B TNF 16083718 1442903 *increased* the tyrosine phosphorylation of [proline-rich tyrosine kinase 2] in acinar cells . Positive_regulation PTK2B TNF 16083718 1442904 *activates* [proline-rich tyrosine kinase 2] to cause cytoskeletal disorganization and nuclear factor-kappaB to cause inflammatory response , and it triggers cell death signaling through divergent mechanisms mediated by protein kinase C . Positive_regulation PTK6 EPHB2 12774925 1095333 We found that Lyn [protein tyrosine kinase] was constitutively phosphorylated on tyrosine , and that and p38 MAPK were constitutively *active* in all cases of the B-cell tumor . Positive_regulation PTK6 EPHB2 15797477 1390352 Moreover , the ConA induced IFN-gamma mRNA expression was partly prevented by genistein , a global [PTK] *inhibitor* , and PD-98059 , an inhibitor , respectively . Positive_regulation PTK6 IL1B 7519214 265516 The results suggest that TNF-alpha and secretion after LPS stimulation of human monocytes *requires* the activation of [protein tyrosine kinase] and PKC , upstream to the activation of gene transcription . Positive_regulation PTK6 IL1B 9230816 444772 Modulation of and TNF-alpha receptors by VLA-5 and VLA-6 *required* [protein tyrosine kinase] activation as herbimycin A ( 10 micrograms/mL ) blocked the affect of Fn and Ln . Positive_regulation PTK6 PECAM1 22000807 2503095 Syk [protein tyrosine kinase] *involves* signaling through tandem immunotyrosine inhibitory motifs in human THP-1 macrophages . Positive_regulation PTK6 STK39 23335513 2753498 Thrombin mediated proteoglycan synthesis utilizes both [protein-tyrosine kinase] and receptor *transactivation* in vascular smooth muscle cells . Positive_regulation PTK6 STK39 23335513 2753588 In contrast , serine/threonine kinase receptor transactivation is mediated by a cytoskeletal rearrangement-Rho kinase-integrin system , and both [protein-tyrosine kinase] and receptor *transactivation* concomitantly account for the total proteoglycan synthesis stimulated by thrombin in vascular smooth muscle . Positive_regulation PTK6 TNF 15240695 1270292 *activates* Syk [protein tyrosine kinase] leading to TNF induced MAPK activation , NF-kappaB activation , and apoptosis . Positive_regulation PTK6 TNF 7541425 310487 Inhibitors of [protein tyrosine kinase] suppress stimulated *induction* of endothelial cell adhesion molecules . Positive_regulation PTK6 TNF 7675795 326321 These findings suggest that , in TNF-resistant cells , *activates* a [protein tyrosine kinase] that contributes to the cell 's resistance to lysis and this resistance mechanism does not function in the TNF-sensitive cell line . Positive_regulation PTK6 TNF 8766564 375001 LPS induced and IL-10 expression *requires* early activation of [protein tyrosine kinases (PTK)] . Positive_regulation PTK6 TNF 9230816 444771 Modulation of IL-1 beta and receptors by VLA-5 and VLA-6 *required* [protein tyrosine kinase] activation as herbimycin A ( 10 micrograms/mL ) blocked the affect of Fn and Ln . Positive_regulation PTK7 EPHB2 12774925 1095347 We found that Lyn [protein tyrosine kinase] was constitutively phosphorylated on tyrosine , and that and p38 MAPK were constitutively *active* in all cases of the B-cell tumor . Positive_regulation PTK7 EPHB2 15797477 1390353 Moreover , the ConA induced IFN-gamma mRNA expression was partly prevented by genistein , a global [PTK] *inhibitor* , and PD-98059 , an inhibitor , respectively . Positive_regulation PTK7 IL1B 7519214 265517 The results suggest that TNF-alpha and secretion after LPS stimulation of human monocytes *requires* the activation of [protein tyrosine kinase] and PKC , upstream to the activation of gene transcription . Positive_regulation PTK7 IL1B 9230816 444774 Modulation of and TNF-alpha receptors by VLA-5 and VLA-6 *required* [protein tyrosine kinase] activation as herbimycin A ( 10 micrograms/mL ) blocked the affect of Fn and Ln . Positive_regulation PTK7 PECAM1 22000807 2503096 Syk [protein tyrosine kinase] *involves* signaling through tandem immunotyrosine inhibitory motifs in human THP-1 macrophages . Positive_regulation PTK7 STK39 23335513 2753513 Thrombin mediated proteoglycan synthesis utilizes both [protein-tyrosine kinase] and receptor *transactivation* in vascular smooth muscle cells . Positive_regulation PTK7 STK39 23335513 2753603 In contrast , serine/threonine kinase receptor transactivation is mediated by a cytoskeletal rearrangement-Rho kinase-integrin system , and both [protein-tyrosine kinase] and receptor *transactivation* concomitantly account for the total proteoglycan synthesis stimulated by thrombin in vascular smooth muscle . Positive_regulation PTK7 TNF 15240695 1270293 *activates* Syk [protein tyrosine kinase] leading to TNF induced MAPK activation , NF-kappaB activation , and apoptosis . Positive_regulation PTK7 TNF 7541425 310488 Inhibitors of [protein tyrosine kinase] suppress stimulated *induction* of endothelial cell adhesion molecules . Positive_regulation PTK7 TNF 7675795 326322 These findings suggest that , in TNF-resistant cells , *activates* a [protein tyrosine kinase] that contributes to the cell 's resistance to lysis and this resistance mechanism does not function in the TNF-sensitive cell line . Positive_regulation PTK7 TNF 8766564 375003 LPS induced and IL-10 expression *requires* early activation of [protein tyrosine kinases (PTK)] . Positive_regulation PTK7 TNF 9230816 444773 Modulation of IL-1 beta and receptors by VLA-5 and VLA-6 *required* [protein tyrosine kinase] activation as herbimycin A ( 10 micrograms/mL ) blocked the affect of Fn and Ln . Positive_regulation PTPN1 CAPN8 11082296 750320 Inhibition of activity not only *inhibits* the proteolytic modification of [protein tyrosine phosphatase 1B] , but also decreases the ability of T cells to adhere to and spread on immobilized fibronectin . Positive_regulation PTPN1 CAPN8 7538126 301172 Several inhibitors did not affect either tyrosine phosphorylation and dephosphorylation or relocation of PTP1B , but they did *inhibit* cleavage of [PTP1B] . Positive_regulation PTPN1 TNF 20576518 2285479 However , TNF-alpha was able to completely blunt the leptin and insulin effect in rats treated with PTP1B-ASO , suggesting that does not *require* [PTP1B] to fully attenuate the leptin and insulin effects . Positive_regulation PTPN1 TNF 21483233 2562073 Rosiglitazone attenuates *induced* [protein-tyrosine phosphatase-1B] production in HepG2 cells . Positive_regulation PTPN1 TNF 21483233 2562076 However , its effect on *induced* [PTP-1B] expression remains to be explored . Positive_regulation PTPN1 TNF 21483233 2562077 In the present study , we sought to identify the mechanism of TNF-a regulated hepatic PTP-1B expression and evaluate the effect of rosiglitazone on *induced* hepatic [PTP-1B] upregulation . Positive_regulation PTPN1 TNF 21483233 2562080 Rosiglitazone significantly blocks *induced* [PTP-1B] upregulation and NF-?B activation . Positive_regulation PTPN1 TNF 21483233 2562081 Our data strongly suggest that TNF-a induced PTP-1B overexpression may contribute to hepatic IR in obesity and diabetes , and NF-?B is involved in rosiglitazone attenuated [PTP- 1B] *upregulation* by . Positive_regulation PTPN11 CAPN8 20398180 2245924 These results suggest that *dependent* cleavage of SHP-1 and [SHP-2] may contribute to protein tyrosine dephosphorylation in Jurkat T cell death induced by E. histolytica . Positive_regulation PTPN11 EPHB2 11085989 810061 The phosphatase activity of SHP-2 is required for both pathways , whereas activation of via Tyr-985 of ObRb also *requires* tyrosine phosphorylation of [SHP-2] . Positive_regulation PTPN11 EPHB2 16705167 1560778 Tcptp-/- macrophages also have increased tyrosine phosphorylation and recruitment of a [Grb2/Gab2/Shp2] complex to the CSF-1R and enhanced *activation* of after CSF-1 stimulation , which are important molecular events in CSF-1 induced differentiation . Positive_regulation PTPN11 EPHB2 18827006 1970783 Significantly , we demonstrate that phosphorylation of [SHP-2] on Y279 downregulates growth factor *induced* sustained activation and proliferation , supporting a role for Abl kinases not only in potentiating growth factor mediated SHP-2 signaling , but also in negative-feedback regulation . Positive_regulation PTPN11 EPHB2 19007960 2016473 Our data suggest that *mediated* phosphorylation of [NS1] at threonine-215 is important for efficient virus replication . Positive_regulation PTPN11 EPHB2 20493809 2263560 By comparing shp2-deficient zebrafish embryos with those injected with mRNA encoding LEOPARD syndrome point mutations , we identify a phosphatase- and *dependent* role for [Shp2] in neural crest specification and migration . Positive_regulation PTPN11 EPHB2 23318428 2860716 It has been controversial how [Shp2] *induces* activation . Positive_regulation PTPN11 EPHB2 9892010 586574 We show that the activation of via SSTR1 is pertussis toxin sensitive and *requires* the small G protein Ras , phosphatidylinositol 3-kinase , the serine/threonine kinase Raf-1 , and the protein tyrosine phosphatase [SHP-2] . Positive_regulation PTPN11 IL1B 16250012 1508403 *induced* tyrosine phosphorylation of [SHP-2] on residue Y542 promoted focal adhesion maturation . Positive_regulation PTPN11 PECAM1 12535670 1049643 Using differentially phosphorylated recombinant proteins we found that phosphotyrosine 686 preferentially mediates binding and 663 mediates *activation* of [SHP-2] by . Positive_regulation PTPN11 PECAM1 12535670 1049644 Thus homophilically engaged , tyrosine phosphorylated locally *activates* [SHP-2] at cell-cell junctions ; Positive_regulation PTPN11 PECAM1 19096001 2036201 These findings reveal that p38MAPK phosphorylation and platelet activation by LDL are suppressed by two mechanisms : ( 1 ) short activation of , and ( 2 ) prolonged *activation* of SHP-1 and [SHP-2] . Positive_regulation PTPN11 PECAM1 9624175 511407 In other studies , we demonstrated that phosphorylation of by Src or Csk family kinases was *sufficient* to trigger its association with [SHP-2] . Positive_regulation PTPN11 PLAU 19133257 2042516 Active PDGFR-beta was required for the *induced* [SHP-2] phosphorylation . Positive_regulation PTPN11 PLAU 19133257 2042518 Elucidating the underlying mechanisms , we found that *induced* [SHP-2] recruitment to lipid rafts . Positive_regulation PTPN11 TNF 12817006 1103562 Since recruitment of the tyrosine phosphatase Src homology protein tyrosine phosphatase 2 ( SHP2 ) to the signal transducing receptor subunit gp130 attenuates IL-6 mediated STAT-activation , we were interested in whether also *induces* the association of [SHP2] to the gp130 receptor subunit . Positive_regulation PTPN11 TNF 12817006 1103564 In this study we demonstrate that stimulation of macrophages and fibroblast cell lines with causes the recruitment of SHP2 to the gp130 signal transducing subunit and *leads* to tyrosine phosphorylation of [SHP2] and gp130 . Positive_regulation PTPN11 TNF 16574984 1568542 SHP-1 and [SHP-2] protein levels were unaltered by TNF or GH , and the GH-induced increase in SHP-1 PTP activity was not further *increased* by . Positive_regulation PTPN11 TNF 19287004 2072958 [SHP2] associated with ASK1 in *response* to in EC . Positive_regulation PTPN22 CAPN8 21841778 2473123 The autoimmune disease associated PTPN22 variant promotes *mediated* [Lyp/Pep] degradation associated with lymphocyte and dendritic cell hyperresponsiveness . Positive_regulation PTPN22 FOLR1 11747307 897995 The T311M A [ bond ] A interface mutant has a decreased affinity for [PEP] and FBP , and is *dependent* on for activity . Positive_regulation PTPN22 FOLR1 19800933 2195824 PK type 1 from Escherichia coli ( Ec-PK1 ) is *activated* by both and its substrate , [phosphoenol pyruvate (PEP)] . Positive_regulation PTPN4 MAP2K6 11722431 884083 In contrast , a inhibitor ( PD98059 ) did not *inhibit* [CFU-Meg] colony formation . Positive_regulation PTPN5 CAPN8 19625523 2112673 Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via *mediated* cleavage of [STEP] . Positive_regulation PTPN5 CAPN8 22435660 2624453 STEP ( 61 ) expression progressively increases after sublethal stretch with no change in *mediated* [STEP] ( 33 ) formation , while lethal stretch injury results in STEP ( 33 ) formation via a NR2B containing NMDA receptor pathway within 1 h of injury . Positive_regulation PTPN5 CAPN8 22435660 2624467 In summary , these data demonstrate that previously characterized pathways of STEP regulation via the NMDA receptor are generally conserved in mechanical injury , and suggest that *mediated* cleavage of [STEP] ( 33 ) should be further examined as an early marker of neuronal fate after stretch injury . Positive_regulation PTPN5 RARB 15736225 1383019 Conversely , the gain-of-function study showed that ectopic expression of in the cerebral cortex *enhanced* [STEP] expression , and the effect was RARbeta-isoform specific . Positive_regulation PTPN6 CAPN8 20398180 2245938 These results suggest that *dependent* cleavage of [SHP-1] and SHP-2 may contribute to protein tyrosine dephosphorylation in Jurkat T cell death induced by E. histolytica . Positive_regulation PTPN6 CD22 7542197 314083 The association between [PTP1C] and CD22 is *dependent* upon tyrosine phosphorylation of , but does not appear to require tyrosine phosphorylation of PTP1C . Positive_regulation PTPN6 PECAM1 19096001 2036205 These findings reveal that p38MAPK phosphorylation and platelet activation by LDL are suppressed by two mechanisms : ( 1 ) short activation of , and ( 2 ) prolonged *activation* of [SHP-1] and SHP-2 . Positive_regulation PTPN6 TNF 11834522 911050 In bovine aortic endothelial cells , we confirmed endogenous SHP-1 expression and that *activated* [SHP-1] . Positive_regulation PTPN6 TNF 16574984 1568543 SHP-1 and SHP-2 protein levels were unaltered by or GH , and the GH-induced increase in [SHP-1] PTP activity was not further *increased* by TNF . Positive_regulation PTPRC CD22 15240561 1295789 A novel approach for simultaneous biotinylation and cross linking showed that CD22 associates with [CD45] and sIgM at much higher levels than reported in prior studies , possibly *involving* cell surface multimers of . Positive_regulation PTPRC ITGAL 7908233 250476 We conclude that cross linking the [leukocyte common antigen] on T cells *induces* -- /ICAM-1 -- dependent T-cell -- monocyte aggregation through a unique signaling pathway independent of PKC , which involves instead cAMP-/cGMP dependent protein kinases . Positive_regulation PTPRC ITGAL 7913942 266513 [CD45] mediated adhesion of activated T cells *involved* both dependent as well as CD11a/18 independent mechanisms . Positive_regulation PTPRC ITGB2 17641028 1771260 In addition , is *required* for the recruitment and localization of talin into the peripheral supramolecular activation cluster region and exclusion of [CD45] from the synapse . Positive_regulation PTPRC TNF 8766549 374978 Epitope-specific engagement of the protein tyrosine phosphatase [CD45] *induces* gene expression via transcriptional mechanisms . Positive_regulation PTS CAPN8 15247926 1274202 We examined the mechanism of this inactivation and found that , in addition to reversible oxidation of PTPs , UV triggers a novel mechanism : induced degradation of [PTPs] by calpain , which *requires* both activation and substrate PTP oxidative modification . Positive_regulation PTS TNF 9788822 541907 Reverse-transcription/limiting-dilution polymerase chain reaction analysis showed that in *response* to , mRNA abundance of GTPCH and [PTPS] was increased approximately 64-fold and 10-fold , respectively . Positive_regulation PTX3 EPHB2 19457093 2101678 This was based on the attenuation of the micro-opioid *activation* of by [pertussis toxin (PTX)] , the CaM antagonist , W-7 , and siRNA silencing of beta-arrestin2 . Positive_regulation PTX3 GPR115 21488183 2417884 [PTX-sensitive] *dependent* H2O2 generation by nLDL plays a critical role in IL-8 production in hAoSMC , and IL-8 may contribute to atherogenesis through increased migration of hAoSMCs . Positive_regulation PTX3 GPR132 21488183 2417873 [PTX-sensitive] *dependent* H2O2 generation by nLDL plays a critical role in IL-8 production in hAoSMC , and IL-8 may contribute to atherogenesis through increased migration of hAoSMCs . Positive_regulation PTX3 GPR87 21488183 2417953 [PTX-sensitive] *dependent* H2O2 generation by nLDL plays a critical role in IL-8 production in hAoSMC , and IL-8 may contribute to atherogenesis through increased migration of hAoSMCs . Positive_regulation PTX3 IL1B 10606983 655878 Unlike the classical pentraxins , the long pentraxin [PTX3] is expressed in *response* to and tumour necrosis factor-alpha (TNF-alpha) , but not to IL-6 , in various cell types . Positive_regulation PTX3 IL1B 10814786 693366 I.c.v . was also a potent *inducer* of [PTX3] expression in the CNS , whereas TNFalpha was substantially less effective and IL-6 induced a barely detectable signal . Positive_regulation PTX3 IL1B 15344601 1292071 Unlike the classical pentraxins , [PTX3] is expressed in *response* to and TNF-alpha but not to IL-6 . Positive_regulation PTX3 IL1B 17538075 1778417 Interleukin 1B (IL1B) , a known inducer of Ptx3 , is also transiently expressed in stromal cells at the implantation site , suggesting that is an *inducer* of uterine [Ptx3] expression . Positive_regulation PTX3 IL1B 17538075 1778418 In fact , uterine [Ptx3] expression *follows* that of induced by lipopolysaccharide treatment on Day 7 of pregnancy . Positive_regulation PTX3 IL1B 18048494 1867330 Also , of the factors secreted by trophoblast , *induces* [PTX3] in human endometrial stromal cells . Positive_regulation PTX3 RGS2 12651916 1085915 Chick *reduces* the inhibition mediated by both the [pertussis toxin (PTX)-sensitive] ( Gi/o coupled ) and the PTX-insensitive ( presumably Gq/11 coupled ) pathways . Positive_regulation PTX3 TLR7 15771574 1384409 [PTX3] is produced by a variety of cells and tissues , most notably dendritic cells and macrophages , in *response* to engagement and inflammatory cytokines . Positive_regulation PTX3 TLR7 16461742 1540849 Dendritic cells ( DC ) of myelomonocytic origin , but not plasmacytoid DC , are a major source of [PTX3] in *response* to engagement . Positive_regulation PTX3 TLR7 16461742 1540882 [PTX3] production was *induced* by ligands , CD40 ligand , and interleukin (IL)-1beta and was suppressed by dexamethasone , 1alpha , 25-dihydroxivitamin D3 , and prostaglandin E2 . Positive_regulation PTX3 TLR7 17023219 1647821 CRP and SAP are produced primarily in the liver in response to IL-6 , while [PTX3] is produced by a variety of tissues and cells and in particular by innate immunity cells in *response* to proinflammatory signals and engagement . Positive_regulation PTX3 TLR7 17278387 1664534 [PTX3] is produced by a variety of cells and tissues , most notably dendritic cells and macrophages , in *response* to engagement and inflammatory cytokines . Positive_regulation PTX3 TLR7 19389798 2100737 Divergent effects were observed with IL-10 , which synergizes with mediated [PTX3] *induction* but inhibits LPS induced TSG-6 transcription . Positive_regulation PTX3 TLR7 19449441 2078822 [PTX3] is produced by a variety of cells and tissues , most notably dendritic cells and macrophages , in *response* to engagement and inflammatory cytokines . Positive_regulation PTX3 TLR7 21226667 2402432 CRP and SAP are produced primarily in the liver in response to IL-6 , while [PTX3] is produced by a variety of tissues and cells and in particular by innate immunity cells in *response* to proinflammatory signals and engagement . Positive_regulation PTX3 TNF 10606983 655877 Unlike the classical pentraxins , the long pentraxin [PTX3] is expressed in *response* to IL-1beta and , but not to IL-6 , in various cell types . Positive_regulation PTX3 TNF 10733100 678366 and interleukin-1 (IL-1) potently *induced* [TSG-14] expression in 3T3 fibroblasts but not in peritoneal macrophages . Positive_regulation PTX3 TNF 15344601 1292070 Unlike the classical pentraxins , [PTX3] is expressed in *response* to IL-1beta and but not to IL-6 . Positive_regulation PTX3 TNF 15673302 1366220 Further analysis showed that interleukin (IL)-1 and stimulation strongly *enhanced* the expression and production of [PTX3] in PTECs in a dose- and time dependent manner . Positive_regulation PTX3 TNF 16339571 1491699 Using human lung cell lines and primary epithelial cells , we found that [PTX3] expression was significantly *up-regulated* by in a time- and dose dependent manner , but not by LPS . Positive_regulation PTX3 TNF 16339571 1491700 Pretreatment with either actinomycin D or cycloheximide abolished *induced* [PTX3] expression , indicating the requirement for both transcriptional and translational regulation . Positive_regulation PTX3 TNF 16339571 1491701 The *induced* [PTX3] expression was blocked by SP600125 , a JNK-specific inhibitor , but not by the inhibitors against NF-kappaB , ERKs , or p38 MAPK . Positive_regulation PTX3 TNF 22284365 2570476 Finally , liraglutide inhibited apoptosis of HUVEC and expression of [Pentraxin-3] *induced* by . Positive_regulation PTX3 TNF 23840908 2816432 Differences between IL-1ß and TNF-a induced hippocampal profiles , specifically for IL-6 and CXCL1 prompted a temporal analysis of systemic and central responses at 1 , 2 , 4 , 8 and 24 hours , which revealed that IL-1ß and both induced the chemokines CXCL1 and CCL2 but only IL-1ß *induced* the pentraxin [PTX3] . Positive_regulation PTX3 TNF 7679696 211304 Nuclear run-on analysis indicated that *induces* the expression of the [TSG-14] gene at the transcriptional level , and that de novo protein synthesis is not required for induction of TSG-14 mRNA . Positive_regulation PTX3 TNF 7949102 277311 was a less-effective *inducer* of [PTX3] , whereas IL-6 , monocyte chemotactic protein-1 , macrophage colony stimulating factor , granulocyte-macrophage colony stimulating factor , and interferon-gamma were inactive . Positive_regulation PTX3 TNF 9521058 493683 PTX3 is a prototypic long [pentraxin] expressed by various cell types , most prominently monocytes and endothelial cells , in *response* to interleukin-1 (IL-1) , and bacterial products . Positive_regulation PTX3 TNF 9950270 589757 Upon *stimulation* with or LPS , HUVEC produced IL-8 and [PTX] affected this process in opposing fashions , with inhibition of the effects of TNF and augmentation of those of LPS . Positive_regulation PTX4 EPHB2 19457093 2101675 This was based on the attenuation of the micro-opioid *activation* of by [pertussis toxin (PTX)] , the CaM antagonist , W-7 , and siRNA silencing of beta-arrestin2 . Positive_regulation PTX4 GPR115 21488183 2417791 [PTX-sensitive] *dependent* H2O2 generation by nLDL plays a critical role in IL-8 production in hAoSMC , and IL-8 may contribute to atherogenesis through increased migration of hAoSMCs . Positive_regulation PTX4 GPR132 21488183 2417780 [PTX-sensitive] *dependent* H2O2 generation by nLDL plays a critical role in IL-8 production in hAoSMC , and IL-8 may contribute to atherogenesis through increased migration of hAoSMCs . Positive_regulation PTX4 GPR87 21488183 2417860 [PTX-sensitive] *dependent* H2O2 generation by nLDL plays a critical role in IL-8 production in hAoSMC , and IL-8 may contribute to atherogenesis through increased migration of hAoSMCs . Positive_regulation PTX4 RGS2 12651916 1085914 Chick *reduces* the inhibition mediated by both the [pertussis toxin (PTX)-sensitive] ( Gi/o coupled ) and the PTX-insensitive ( presumably Gq/11 coupled ) pathways . Positive_regulation PTX4 TNF 22284365 2570475 Finally , liraglutide inhibited apoptosis of HUVEC and expression of [Pentraxin-3] *induced* by . Positive_regulation PTX4 TNF 9521058 493682 PTX3 is a prototypic long [pentraxin] expressed by various cell types , most prominently monocytes and endothelial cells , in *response* to interleukin-1 (IL-1) , and bacterial products . Positive_regulation PTX4 TNF 9950270 589755 Upon *stimulation* with or LPS , HUVEC produced IL-8 and [PTX] affected this process in opposing fashions , with inhibition of the effects of TNF and augmentation of those of LPS . Positive_regulation PVR EDN2 1898679 152014 in the large dose ( 4.118 micrograms/kg ) produced a prolonged decrease in the indices of cardiac contractility and cardiac function and *increases* in TSVR , [PVR] , and mean right atrial pressure . Positive_regulation PVR EDN2 1898679 152017 These results suggest that decreased cardiac function and cardiac contractility and *increased* SVR and [PVR] . Positive_regulation PVR TNF 1542546 180886 The *induced* rise in mean pulmonary artery pressure and [PVR] was inhibited by the PTF until 2 h , by which time PVR was elevated above baseline and was comparable to the value found in animals treated with only TNF alpha . Positive_regulation PVR TNF 1741548 171742 *resulted* in increases in pulmonary arterial pressure ( Ppa ) and [pulmonary vascular resistance (PVR)] within 15 min , and the values were sustained for the 5-h experiment duration . Positive_regulation PXN CAPN8 10545505 564614 Thus , collagen fragments induce distinct integrin signals that lead to initiation of *mediated* cleavage of pp125(FAK) , [paxillin] , and talin and dissolution of the focal adhesion complex . Positive_regulation PXN CAPN8 11511102 848860 In contrast , the cleavage of [paxillin] and p130cas in apoptotic L929 cells was *blocked* by inhibitors , which also reduced the death rate by 23 to 44 % . Positive_regulation PXN CAPN8 12490576 1033301 The goal of the present study was to determine the *role* of in changes in plasma membrane permeability and cytoskeleton associated [paxillin] , vinculin , talin , and alpha-actinin levels during acute renal cell death . Positive_regulation PXN CAPN8 23936270 2826897 Degradation of [paxillin] in CD45-deficient macrophages is *mediated* , as treatment with a calpain inhibitor restores paxillin levels in these cells and enhances cell spreading . Positive_regulation PXN EDN2 15911746 1420304 We have investigated the role of the actin cytoskeleton in noradrenaline ( NA ) -induced and *induced* activation of the calcium dependent nonreceptor tyrosine kinase PYK2 and subsequent phosphorylation of [paxillin] in rat small mesenteric arteries . Positive_regulation PXN EDN2 17707940 1800766 In contrast , *increased* tyrosine phosphorylation of focal adhesion kinase ( FAK ) and [paxillin] in an integrin ligand dependent manner . Positive_regulation PXN EDN2 17707940 1800772 A PKC inhibitor and down-regulation of PKC prevented *induced* phosphorylation of [paxillin] and ERK . Positive_regulation PXN EDN2 8408063 233233 Bombesin , vasopressin , and rapidly *stimulate* tyrosine phosphorylation of the focal adhesion associated protein [paxillin] in Swiss 3T3 cells . Positive_regulation PXN EDN2 8408063 233236 Vasopressin and also *stimulated* [paxillin] tyrosine phosphorylation . Positive_regulation PXN EDN2 8631827 357212 In contrast , tyrosine phosphorylation of p125FAK and [paxillin] in *response* to bombesin , , and phorbol 12,13-dibutyrate was not inhibited by wortmannin in these cells . Positive_regulation PXN EPHB2 11784715 916703 Hepatocyte growth factor induces *dependent* [paxillin] phosphorylation and regulates paxillin-focal adhesion kinase association . Positive_regulation PXN EPHB2 11784715 916711 Thus , these data suggest that HGF can induce serine/threonine phosphorylation of [paxillin] most probably *mediated* directly by , resulting in the recruitment and activation of FAK and subsequent enhancement of cell spreading and adhesion . Positive_regulation PXN EPHB2 18973190 2078973 c-Fos accelerates hepatocyte conversion to a fibroblastoid phenotype through *mediated* upregulation of [paxillin-Serine178] phosphorylation . Positive_regulation PXN EPHB2 20628053 2310212 Furthermore , EGFR induced activation *requires* Src mediated phosphorylation of [paxillin] on tyrosines 31/118 . Positive_regulation PXN EPHB2 20628053 2310214 However , *mediated* phosphorylation of [paxillin] on serines 83/126/130 is still needed for both EGFR and PKC mediated cellular proliferation . Positive_regulation PXN EPHB2 20628053 2310218 Importantly , *mediated* serine phosphorylation of [paxillin] is also required for DHT induced prostate-specific antigen mRNA expression in LnCAP cells as well as EGF induced cyclin D1 mRNA expression in PC3 cells , suggesting that paxillin may regulate prostate cancer proliferation by serving as a liaison between extra-nuclear kinase signaling and intra-nuclear transcriptional signals . Positive_regulation PXN F2R 11278329 798208 Activation of *increased* the phosphorylation of focal adhesion kinase and [paxillin] , and the induced formation of focal contact complexes . Positive_regulation PXN ITGB2 21270398 2392764 Whereas CD16 activated Ca ( 2+ ) mobilization and LAT phosphorylation , did not , but *induced* strong Pyk2 and [paxillin] phosphorylation . Positive_regulation PXN ITGB2 22017400 2539838 Depletion of by RNA interference *leads* to parallel down-regulation of CD11b and CD11c , as well as of [paxillin] , and the disappearance of the adhesion-like coats . Positive_regulation PXN TLR7 12616494 1065697 PP2 , an inhibitor of Src family tyrosine kinases , prevented the *induced* phosphorylation of [paxillin] and Pyk2 without affecting TLR induced IRAK activation . Positive_regulation PXN TNF 10415163 631210 Concurrently , rapidly *induced* tyrosine phosphorylation of both [paxillin] and focal adhesion kinase , without affecting the expression levels of these two proteins . Positive_regulation PXN TNF 23674089 2819301 Furthermore , FAN mediated *induced* [paxillin] phosphorylation , metalloproteinase activation and increased extracellular matrix degradation , the hallmarks of functionally active invadopodia . Positive_regulation PXN TNF 7525608 276953 In the present work , *stimulated* tyrosine phosphorylation of [paxillin] in human neutrophils . Positive_regulation PXN TNS1 7566975 328515 IL-3 *induced* a transient association between [paxillin] and vinculin , while in BCR/ABL transformed cells , several proteins coimmunoprecipitated with paxillin , including vinculin , p125FAK , talin and . Positive_regulation PYCARD TNF 16715133 1638302 *Induction* of [TMS1/ASC] by was blocked by co-expression of a dominant negative IkappaBalpha , small interfering RNA mediated knockdown of RelA/p65 , or concurrent treatment with SP600125 , indicating a requirement for the nuclear factor-kappaB (NF-kappaB) and jun kinase signaling pathways . Positive_regulation PYY GLP1R 22916913 2657724 The predominant expression of [PYY] , Y2 , and GCG in the gut , and the *presence* of in multiple peripheral tissues suggest a role for PYY in controlling gut functions and for GLP-1 in regulating multiple physiological functions in cattle . Positive_regulation PYY TNF 1733367 181591 *induced* elevation of [PYY] levels in portal plasma with no change in other gut peptide levels . Positive_regulation QRICH1 EFNB1 21655447 2442331 Using HPLC , we *observed* an enhanced release of L/D-serine and [glutamine] from cultured astrocytes following and/or ephrinB3 stimulation . Positive_regulation QRICH1 TGM2 11877487 919115 It is known that the enzyme is *involved* in the generation of T cell stimulatory gluten peptides through deamidation of [glutamine] , the most abundant amino acid in gluten . Positive_regulation QRICH2 EFNB1 21655447 2442333 Using HPLC , we *observed* an enhanced release of L/D-serine and [glutamine] from cultured astrocytes following and/or ephrinB3 stimulation . Positive_regulation QRICH2 TGM2 11877487 919116 It is known that the enzyme is *involved* in the generation of T cell stimulatory gluten peptides through deamidation of [glutamine] , the most abundant amino acid in gluten . Positive_regulation RAB31 AKT1 18650435 1966993 *mediated* [Rab-GAP] AS160 phosphorylation and Rac/actin are required for net insulin gain of GLUT4 , but the specific steps ( vesicle recruitment , docking or fusion ) regulated by Rac , actin dynamics , and AS160 target Rab8A are unknown . Positive_regulation RAB31 AKT2 18650435 1966994 *mediated* [Rab-GAP] AS160 phosphorylation and Rac/actin are required for net insulin gain of GLUT4 , but the specific steps ( vesicle recruitment , docking or fusion ) regulated by Rac , actin dynamics , and AS160 target Rab8A are unknown . Positive_regulation RAB31 AKT3 18650435 1966995 *mediated* [Rab-GAP] AS160 phosphorylation and Rac/actin are required for net insulin gain of GLUT4 , but the specific steps ( vesicle recruitment , docking or fusion ) regulated by Rac , actin dynamics , and AS160 target Rab8A are unknown . Positive_regulation RAB31 CHM 21939745 2492374 is *essential* for the posttranslational activation of retina-specific [Rab] protein . Positive_regulation RAB31 EEA1 24644286 2934622 We found that loss of *reduced* the interaction between [Rab31] and the EGFR and abrogated the effect of Rab31 overexpression on the trafficking of the EGFR . Positive_regulation RAB31 EGFR 24644286 2934619 [Rab31] was found to interact with the EGFR by coimmunoprecipitation and affinity pulldown analyses , and the primarily trans-Golgi network localized Rab31 has *increased* colocalization with the in A431 cells 30 min after pulsing with EGF . Positive_regulation RAB31 EVI5 22778279 2627818 *requires* its [Rab-GAP] activity to fulfill its functions during migration and acts as a GAP protein for Rab11 . Positive_regulation RAB31 GAPVD1 24644286 2934625 Likewise , loss of , a Rab31 guanine nucleotide exchange factor that has a role in ubiquitination and degradation of the EGFR , *reduced* the interaction of [Rab31] with the EGFR and its effect on EGFR trafficking . Positive_regulation RAB31 GDI1 20064470 2177655 Thus , apparent GDI displacement by DrrA is linked directly to nucleotide exchange , suggesting a basic model for GDI displacement and specificity of [Rab] localization that does not *require* discrete displacement activity . Positive_regulation RAB31 GDI2 20064470 2177656 Thus , apparent GDI displacement by DrrA is linked directly to nucleotide exchange , suggesting a basic model for GDI displacement and specificity of [Rab] localization that does not *require* discrete displacement activity . Positive_regulation RAB31 HSP90AA1 12426384 1014487 [Rab-alphaGDI] activity is *regulated* by a chaperone complex . Positive_regulation RAB31 HSP90AA1 16473600 1495845 Recycling of Rab GTPases is likely to require a membrane bound complex of GDI , Hsp90 , and [Rab] given that alphaGDI dependent recycling of Rab3A at the synapse and neurotransmitter transmitter release is *inhibited* by inhibitors . Positive_regulation RAB31 IL2 22022086 2499040 Thirty-seven of 92 ( 40.2 % ) patients in the MMF group and 70/113 ( 61.9 % ) patients in the AZA group received [RAb] *induction* ( P=0.002 ) . 32 patients ( 15.6 % ) developed AR within a year . Positive_regulation RAB31 INS 12637568 1079940 *stimulated* phosphorylation of a [Rab] GTPase activating protein regulates GLUT4 translocation . Positive_regulation RAB31 INS 15159548 1252740 Accordingly , Noc2 positively regulates secretion from endocrine pancreas by inhibiting Gi/o signaling , and the interaction of Noc2 and [Rab3] is *required* for the effect . Positive_regulation RAB31 INS 21041651 2349127 We conclude that Rab13 and Rab8A are [Rab-GTPases] *activated* by , and that downstream of AS160 they regulate traffic of GLUT4 vesicles , possibly acting at distinct steps and sites . Positive_regulation RAB31 MYEF2 18510933 1918322 The effect of the dependent retrograde signal on secretion is *mediated* by the synaptic vesicle protein [RAB-3] . Positive_regulation RAB31 PLCB1 9307015 454394 P1 also activated recombinant PLC-beta1 , indicating direct *activation* of by [Rab3] effector-domain peptides . Positive_regulation RAB31 RASA1 8662963 367727 In vitro REP . Rab binding assays demonstrate that REP forms a stable complex only with the GDP bound form of Rab but not the GTP bound form , suggesting that the apparent Km effect in the prenylation reaction is due to a discrimination between the two different nucleotide bound forms of Rab by REP. Inasmuch as Rabs are likely GTP bound after synthesis and REP does not possess GTPase activating protein activity , these results raise the possibility that a Rab *enhances* the [REP*Rab] interaction prior to prenylation . Positive_regulation RAB31 RPH3AL 15159548 1252739 Accordingly , positively regulates insulin secretion from endocrine pancreas by inhibiting Gi/o signaling , and the interaction of Noc2 and [Rab3] is *required* for the effect . Positive_regulation RAB31 SLC2A4RG 20797862 2324414 [Rab-GDP] *requires* a for its conversion to the active GTP form . Positive_regulation RAB31 SLC2A4RG 22593206 2619773 This ensures specificity of the subsequent mediated *activation* of the [Rab] that initiates the next transport event . Positive_regulation RAB31 SLC2A4RG 23329412 2742993 Sensitive homology searches showed that C9ORF72 is a full-length distant homologue of proteins related to Differentially Expressed in Normal and Neoplasia ( DENN ) , which is a that *activates* [Rab-GTPases] . Positive_regulation RAB31 SNCA 15099020 1239023 Rather , alpha-synuclein interactions with [Rab] proteins are *due* to mutant as demonstrated in Rab pull-down assays with recombinant of wildtype and mutant A30P human alpha-synuclein . Positive_regulation RAB3A RAB31 11809763 917014 [GDP-Rab3A] is *activated* to GTP-Rab3A by , and GTP-Rab3A is inactivated to GDP-Rab3A by Rab3 GTPase activating protein ( Rab3 GAP ) . Positive_regulation RAB3A RAB31 16473606 1495937 [GDP-Rab3A] is *activated* to GTP-Rab3A by , and GTP-Rab3A is inactivated to GDP-Rab3A by Rab3 GTPase activating protein ( Rab3 GAP ) . Positive_regulation RAB4A RAB31 9524117 494423 Distinct binding domains *mediate* the interaction of Rabaptin-5 with GTP bound [Rab4] and Rab5 . Positive_regulation RAB5A RAB31 9524117 494450 Distinct binding domains *mediate* the interaction of Rabaptin-5 with GTP bound Rab4 and [Rab5] . Positive_regulation RAB6A TNF 23437303 2744565 We found that induction of secretion by LPS *promoted* the selective increase of [Rab6] expression . Positive_regulation RAB7A FOXO1 20947830 2353757 *increased* expression of [Rab7] , a small GTP binding protein that mediates late autophagosome-lysosome fusion , which was both necessary and sufficient for mediating FoxO1 induced increases in autophagic flux . Positive_regulation RABEP1 RAB31 9524117 494396 Distinct binding domains *mediate* the interaction of [Rabaptin-5] with GTP bound Rab4 and Rab5 . Positive_regulation RABEPK EPHB2 12871593 1114148 In addition , we show that [p40] *induced* the activation of both extracellular signal regulated kinase ( ) and p38 mitogen activated protein kinase (MAPK) . Positive_regulation RABEPK EPHB2 19306359 2127965 IL-12 [p40] ( 2 ) alone *induced* the activation of both extracellular signal regulated kinase ( ) and p38 mitogen activated protein kinase (MAPK) . Positive_regulation RABEPK EPHB2 20121399 2206950 In THP-1 cells , p38 , , and JNK inhibition *increased* NF-kappaB and Sp1 binding to the [IL-12p40] promoter , while inhibiting AP-1 binding . Positive_regulation RABEPK ITGB2 11123339 768811 In contrast , for optimal induction of COX-2 , IL-12 p35 , and IL-12 [p40] genes by low concentrations of LPS or by all concentrations of Taxol , was also *required* . Positive_regulation RABEPK TGM2 16382148 1505650 Here , we report that the Ca2+ dependent protein cross linking enzyme is *involved* in THG induced [p40] and p64 formation by catalyzing caspase 3 cross linking reactions , thereby inactivating caspase 3 and apoptosis in Bax-deficient cells . Positive_regulation RABEPK TLR7 17521321 1767152 natural killer (NK)1.1 ( - ) CD11c ( + ) liver DC subsets ( conventional DCs , T cell receptor ( TcR ) beta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( - ) and plasmacytoid DCs , TcRbeta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( + ) ) efficiently endocytose dextran and produce significant levels of tumour necrosis factor (TNF)-alpha , interleukin (IL)-6 and IL-12 [p40] in *response* to ligands , with responses higher than splenic DCs . Positive_regulation RABEPK TLR7 18276743 2010188 *dependent* induction of p19 , [p40] and bioactive IL23 was determined in RA synovial fibroblasts ( RASF ) , monocytes and monocyte derived dendritic cells ( MDDCs ) by real-time PCR and reverse transcriptase ( RT ) -PCR , Western blot and functional assays . Positive_regulation RABEPK TLR7 18276743 2010238 The dependent *induction* of p19 but not [p40] in RASF and the abundant expression of p19 along with the low or undetectable levels of IL23 in patients with RA provides strong evidence that p19 does not necessarily indicate the presence of IL23 , as has been proposed to date . Positive_regulation RABEPK TLR7 19201871 2033859 Kinetic of RelA activation controls magnitude of mediated [IL-12p40] *induction* . Positive_regulation RABEPK TLR7 19322177 2064456 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and [IL-12p40] ( also known as IL12b ) , but not TNF , in *response* to ligands . Positive_regulation RABEPK TLR7 22896633 2666473 p38 MAPK activation and IL-12p70 production was more robust from TFF2 ( -/- ) CD8+ DC compared with WT CD8+ DC and treatment of WT DC with rTFF2 suppressed *induced* [IL-12/23p40] production . Positive_regulation RABEPK TLR7 23966630 2836161 Whereas TLR9 induced TNF-a secretion of bone marrow derived macrophages and conventional dendritic cells was equally inhibited by INH-ODN 2088 and G-modified INH-ODNs such as INH-ODN 24888 , *induced* TNF-a release and TLR7- and TLR9 induced [IL-12p40] release were significantly more impaired by G-modified INH-ODNs . Positive_regulation RABEPK TNF 15963988 1428208 More importantly , *induced* LC to produce both IFN-gamma-inducible-protein IP-10/CXCL10 , a Th1 attracting chemokine and IL-12 [p40] . Positive_regulation RABEPK TNF 20822815 2346066 On day 12 , induction in monocyte derived macrophages and IL-12 [p40] *induction* in BAL macrophages infected with R. equi was significantly higher in foals treated with PPVO than in controls . Positive_regulation RAC1 ANGPT1 21885850 2496449 *requires* IQ domain GTPase activating protein 1 to activate [Rac1] and promote endothelial barrier defense . Positive_regulation RAC1 ANGPT1 22936663 2688017 This complex brings Par3 , Par6 , and adherens junction proteins at the front of migrating cells to locally activate [Rac1] in *response* to . Positive_regulation RAC1 CAPN8 11062268 746648 In contrast , while [Rac-] and Rho-GTPases were *dependent* on for their activation , formation of focal complexes and focal adhesions by constitutively active Rac or Rho , respectively , occurred even when calpain inhibitors were present . Positive_regulation RAC1 CAPN8 22721990 2626965 This effect is elicited through reorganization of the cytoskeleton and focal adhesion , *activation* of RhoA and [Rac1] , and mediated cleavage of pp125(FAK) . Positive_regulation RAC1 CCND1 10464245 640353 Inhibiting NF-kappaB by overexpression of an NF-kappaB trans-dominant inhibitor ( nonphosphorylatable IkappaBalpha ) reduced cyclin D1 promoter activation by the Rac1 mutants , placing NF-kappaB in a pathway of [Rac1] *activation* of . Positive_regulation RAC1 CCND1 19765988 2140732 In contrast , FAK dependent [Rac] activation , Rac dependent gene *induction* , and cyclin D1-dependent Rb phosphorylation are strongly inhibited at physiological tissue stiffness and rescued when the matrix is stiffened in vitro . Positive_regulation RAC1 EPHB2 12511425 1070760 PAK1 ( p21 activated kinase 1 ) activation is induced by C albicans , suggesting that PAK1 may also be involved in the [Rac1] *activation* of . Positive_regulation RAC1 EPHB2 12546821 1051240 Activation of the receptor *induces* translocation of the Rho-GEF kalirin to synapses and activation of [Rac1] and its effector PAK . Positive_regulation RAC1 EPHB2 12892714 1117807 signaling coordinately *regulates* activity of [Rac1] and RhoA for tumor cell motility . Positive_regulation RAC1 EPHB2 14557270 1186069 Inhibition of or PAK2 , the kinases upstream of p85 betaPIX in the bFGF signaling , *prevents* [Rac1] activation , suggesting that phosphorylation of p85 betaPIX functions upstream of Rac1 activation . Positive_regulation RAC1 EPHB2 17088251 1675908 We investigated whether Src and [Rac1] mediate deformation *induced* FAK and phosphorylation and proliferation in human Caco-2 and rat IEC-6 intestinal epithelial cells . Positive_regulation RAC1 EPHB2 17363898 1720405 Second , ARF6 induced activation *regulates* [Rac1] activation during tubule initiation through the expression of the receptor for urokinase type plasminogen activator . Positive_regulation RAC1 EPHB2 20526801 2320125 In this study , we investigated whether *regulates* [Rac1/Pak1] signaling and is critically linked to MB cell migration . Positive_regulation RAC1 EPHB2 20526801 2320149 We conclude that [Rac1/Pak1] signaling is critical to MB cell migration and is functionally *dependent* on activity . Positive_regulation RAC1 EPHB2 21980400 2493077 PI3K and *induced* [Rac1] activation mediates hypoxia induced HIF-1a expression in MCF-7 breast cancer cells . Positive_regulation RAC1 EPHB2 21980400 2493085 Taken together , our study demonstrated that hypoxia induced HIF-1a expression involves a cascade of signaling events including ROS generation , *activation* of PI3K and signaling , and subsequent activation of [Rac1] . Positive_regulation RAC1 EPHB2 22617030 2614673 Autonomous activation by uPAR *requires* H-Ras and [Rac1] . Positive_regulation RAC1 EPHB2 23817184 2815746 The results of the present study show that ERK could be activated by PI3 kinase , PDK1 , Akt , and Rac1 and that alternatively , Akt and [Rac1] could be *activated* by MEK and in MSTO-211H cells . Positive_regulation RAC1 EPHB2 24043306 2857280 Green fluorescent protein ( GFP ) -Rac1 is threonine ( T ) phosphorylated in response to epidermal growth factor (EGF) , and EGF induced [Rac1] threonine phosphorylation is *dependent* on the activation of . Positive_regulation RAC1 F2R 17373694 1720566 LNCaP migration was enhanced twofold and [Rac1/Cdc42] signaling was *activated* by stimulation of and PAR-2 . Positive_regulation RAC1 ID1 21053361 2370788 GTPase activity assays showed that over-expression or short-hairpin RNA knockdown of *led* to corresponding changes in [Rac1] activity , whereas RhoA activity was significantly decreased with Id-1 depletion . Positive_regulation RAC1 IL1B 20231290 2254609 PTX induced biphasic increases in Rac activity , and the Rac activation in a late but not an early phase was suppressed by IL-1beta siRNA , suggesting that *induced* [Rac] activation contributes to the amplification of Rac dependent signaling induced by PTX . Positive_regulation RAC1 ITGB2 14960575 1227734 Herein we show that *induces* a potent and transient increase in the activity of the small GTPase [Rac-1] in T cells . Positive_regulation RAC1 ITGB2 14960575 1227762 We have identified Vav , a guanine nucleotide exchange factor for Rac-1 , and PI3K/Akt , as regulators of the activation and inactivation phases of the activity of Rac-1 , respectively , in the context of LFA-1 signaling based on the following experimental evidence : ( i ) LFA-1 induced activation of Vav and PI3K/Akt with kinetics consistent with a regulatory role for these molecules on Rac-1 , ( ii ) overexpression of a constitutively active Vav mutant induces activation of Rac independently of LFA-1 stimulation whereas overexpression of a dominant negative Vav mutant blocks mediated [Rac] *activation* , ( iii ) pharmacological inhibition of PI3K/Akt prevented the fall in the activity of Rac-1 after its initial activation but had no effect on Vav activity , and ( iv ) overexpression of a dominant negative or a constitutively active Akt-1 induced or inhibited , respectively , Rac-1 activity . Positive_regulation RAC1 ITGB2 21206905 2359241 Engagement of to its ligand , ICAM-1 , in human peripheral T cells *resulted* in rapid activation of [Rac1] and Rac2 . Positive_regulation RAC1 MAP2K6 17183546 1695270 In the present study , we demonstrate that activation by EGF *increased* [Rac1] activation , dissociation of intercellular contacts , and migration in both control and polyamine depleted cells , while U0126 , a specific inhibitor of MEK1 , prevented disruption of junctions as well as EGF induced Rac1 activation . Positive_regulation RAC1 MAP2K6 23817184 2815739 In the FRET analysis , [Rac1] was activated under the basal conditions , and the activation was *inhibited* by a inhibitor and an ERK1/2 inhibitor . Positive_regulation RAC1 MAP2K6 23817184 2815752 The results of the present study show that ERK could be activated by PI3 kinase , PDK1 , Akt , and Rac1 and that alternatively , Akt and [Rac1] could be *activated* by and ERK in MSTO-211H cells . Positive_regulation RAC1 MMP28 22786680 2627978 We show that expression of mouse Rac1b in lung epithelial cells of transgenic mice stimulated EMT and spontaneous tumor development and that activation of EMT by *induced* expression of [Rac1b] gave rise to lung adenocarcinoma in the transgenic mice through bypassing oncogene induced senescence . Positive_regulation RAC1 MMP28 22972461 2719941 Motility increase required [Rac1] activation and RhoA inhibition and was *inhibited* by an inhibitor . Positive_regulation RAC1 MMP7 22786680 2627993 We show that expression of mouse Rac1b in lung epithelial cells of transgenic mice stimulated EMT and spontaneous tumor development and that activation of EMT by *induced* expression of [Rac1b] gave rise to lung adenocarcinoma in the transgenic mice through bypassing oncogene induced senescence . Positive_regulation RAC1 MMP7 22972461 2719956 Motility increase required [Rac1] activation and RhoA inhibition and was *inhibited* by an inhibitor . Positive_regulation RAC1 NEDD9 22328516 2592248 interacts with the guanine nucleotide exchange factor DOCK3 to *promote* [Rac] activation and the elongated , mesenchymal-type of tumour cell invasion , but the molecular mechanisms through which NEDD9 promotes melanoma metastasis are not fully understood . Positive_regulation RAC1 NEDD9 22677287 2611463 Elongated mesenchymal migration of cancer cells is driven by [Rac1] activation *mediated* by the adaptor and the exchange factor DOCK3 . Positive_regulation RAC1 NOSTRIN 22751148 2634462 forms a complex with the GTPase Rac1 and its exchange factor Sos1 and overexpression of NOSTRIN in cells *induces* [Rac1] activation . Positive_regulation RAC1 NOSTRIN 22751148 2634463 Furthermore , is *required* for fibroblast growth factor 2 dependent activation of [Rac1] in primary endothelial cells and the angiogenic response to fibroblast growth factor 2 in the in vivo matrigel plug assay . Positive_regulation RAC1 PLAU 12719789 1084090 Endogenous RhoA , but not [Rac1] or Cdc42 , was significantly activated in *response* to . Positive_regulation RAC1 S100B 21209080 2391871 The dependent *activation* of [diaphanous-1/Rac1/JNK/AP-1] , Ras/Rac1/NF-?B and Src/Ras/PI3K/RhoA/diaphanous-1 results in the up-regulation of expression of the chemokines , CCL3 , CCL5 , and CXCL12 , whose release and activity are required for S100B to stimulate microglia migration . Positive_regulation RAC1 S1PR3 12069818 955552 Consistent with this , Edg1 and , and Edg5 *regulate* the activity of the Rho family GTPase [Rac] positively and negatively , respectively . Positive_regulation RAC1 S1PR3 12588974 1059727 In contrast to S1P2 , *mediated* S1P directed , pertussis toxin-sensitive chemotaxis and [Rac] activation despite concurrent stimulation of Rho via G12/13 . Positive_regulation RAC1 TLR7 21098092 2357765 Plexin-A4 is required for induced *activation* of the small guanosine triphosphate hydrolase ( GTPase ) [Rac1] ( ras related C3 botulinum toxin substrate 1 ) . Positive_regulation RAC1 TNF 11453646 837058 Using the Rac binding domain of PAK ( PAK-RBD ) as an activation-specific probe , here we demonstrate that very rapidly and transiently *activates* the Rho family GTPase [Rac] in L929 cells . Positive_regulation RAC1 TNF 15242860 1289559 Overexpression of dominant negative form of CREB suppressed VSMC migration as well as [Rac1] expression *induced* by . Positive_regulation RAC1 TNF 15242860 1289563 CREB inhibition suppressed *induced* VSMC migration and [Rac1] expression . Positive_regulation RAC1 TNF 15647276 1402295 stimulation of EC *increased* the membrane association of [Rac1] , an event that is essential for Rac1 activity . Positive_regulation RAC1 TNF 15647276 1402296 also *increased* the level of [GTP-Rac1] , the active form of Rac1 , in EC . Positive_regulation RAC1 TNF 18258304 1884809 This would suggest that *induced* activation of [Rac] , lies upstream of NF-kappaB activation , and that the inhibition of this pathway results in inhibition of cytokine production . Positive_regulation RAC1 TNF 19473519 2091157 TNF-alpha induced phosphorylation of Rac , while atorvastatin and Rac-1 inhibitor inhibited the phosphorylation of [Rac] *induced* by . Positive_regulation RAC1 TNF 20805415 2324606 Enhanced Rac activation and phagocytosis following IFN-? priming were dependent on NO production via inducible NO synthase and activation of protein kinase G. Notably , endogenous production of in response to IFN-? priming was critically *required* for inducible NO synthase upregulation , NO production , [Rac] activation , and enhanced phagocytosis . Positive_regulation RAC1 TNF 22965143 2706257 *stimulated* [Rac] activation and reactive oxygen species production in a P-Rex1 dependent manner . Positive_regulation RAC1 TNF 23383114 2739505 Caveolin-1 regulates [Rac1] activation and rat pulmonary microvascular endothelial hyperpermeability *induced* by . Positive_regulation RAC1 TNF 23389627 2759185 Taken together , our findings can explain the mechanisms leading to hierarchical *activation* of [Rac] and RhoA by through a single GEF . Positive_regulation RAC1 TNF 23608189 2795247 Chemical or genetic inhibition of ERK5 ablated the statins inhibition of [Rac-1] activation , ROS formation , NF-?B , VCAM-1 and ICAM-1 expression *induced* by . Positive_regulation RAC1 TNF 23608189 2795249 Taken together , statins , via ERK5 activation , suppress *stimulated* [Rac-1] activation , ROS generation , NF-?B activation and VCAM-1 and ICAM-1 expression in human ECs , which provides a novel explanation for the pleiotropic effects of statins that benefit the cardiovascular system . Positive_regulation RAC1 WNT7A 15802269 1410470 induced the accumulation of beta-catenin and the activation of Rac and beta-catenin , and [Rac] synergistically *induced* the transcription of MMP-12 . Positive_regulation RAC1 WNT7A 24711502 2931818 Here we describe a third level of activity where *increases* the polarity and directional migration of mouse satellite cells and human myogenic progenitors through activation of Dvl2 and the small GTPase [Rac1] . Positive_regulation RAC2 CAPN8 11062268 746662 In contrast , while [Rac-] and Rho-GTPases were *dependent* on for their activation , formation of focal complexes and focal adhesions by constitutively active Rac or Rho , respectively , occurred even when calpain inhibitors were present . Positive_regulation RAC2 CCND1 19765988 2140733 In contrast , FAK dependent [Rac] activation , Rac dependent gene *induction* , and cyclin D1-dependent Rb phosphorylation are strongly inhibited at physiological tissue stiffness and rescued when the matrix is stiffened in vitro . Positive_regulation RAC2 IL1B 20231290 2254612 PTX induced biphasic increases in Rac activity , and the Rac activation in a late but not an early phase was suppressed by IL-1beta siRNA , suggesting that induced [Rac] *activation* contributes to the amplification of Rac dependent signaling induced by PTX . Positive_regulation RAC2 ITGB2 14960575 1227766 We have identified Vav , a guanine nucleotide exchange factor for Rac-1 , and PI3K/Akt , as regulators of the activation and inactivation phases of the activity of Rac-1 , respectively , in the context of LFA-1 signaling based on the following experimental evidence : ( i ) LFA-1 induced activation of Vav and PI3K/Akt with kinetics consistent with a regulatory role for these molecules on Rac-1 , ( ii ) overexpression of a constitutively active Vav mutant induces activation of Rac independently of LFA-1 stimulation whereas overexpression of a dominant negative Vav mutant blocks mediated [Rac] *activation* , ( iii ) pharmacological inhibition of PI3K/Akt prevented the fall in the activity of Rac-1 after its initial activation but had no effect on Vav activity , and ( iv ) overexpression of a dominant negative or a constitutively active Akt-1 induced or inhibited , respectively , Rac-1 activity . Positive_regulation RAC2 ITGB2 21206905 2359242 Engagement of to its ligand , ICAM-1 , in human peripheral T cells *resulted* in rapid activation of Rac1 and [Rac2] . Positive_regulation RAC2 NEDD9 22328516 2592250 interacts with the guanine nucleotide exchange factor DOCK3 to *promote* [Rac] activation and the elongated , mesenchymal-type of tumour cell invasion , but the molecular mechanisms through which NEDD9 promotes melanoma metastasis are not fully understood . Positive_regulation RAC2 S1PR3 12069818 955555 Consistent with this , Edg1 and , and Edg5 *regulate* the activity of the Rho family GTPase [Rac] positively and negatively , respectively . Positive_regulation RAC2 S1PR3 12588974 1059728 In contrast to S1P2 , *mediated* S1P directed , pertussis toxin-sensitive chemotaxis and [Rac] activation despite concurrent stimulation of Rho via G12/13 . Positive_regulation RAC2 TNF 11453646 837059 Using the Rac binding domain of PAK ( PAK-RBD ) as an activation-specific probe , here we demonstrate that very rapidly and transiently *activates* the Rho family GTPase [Rac] in L929 cells . Positive_regulation RAC2 TNF 18258304 1884810 This would suggest that induced *activation* of [Rac] , lies upstream of NF-kappaB activation , and that the inhibition of this pathway results in inhibition of cytokine production . Positive_regulation RAC2 TNF 19473519 2091159 TNF-alpha induced phosphorylation of Rac , while atorvastatin and Rac-1 inhibitor inhibited the phosphorylation of [Rac] *induced* by . Positive_regulation RAC2 TNF 20805415 2324607 Enhanced Rac activation and phagocytosis following IFN-? priming were dependent on NO production via inducible NO synthase and activation of protein kinase G. Notably , endogenous production of in response to IFN-? priming was critically *required* for inducible NO synthase upregulation , NO production , [Rac] activation , and enhanced phagocytosis . Positive_regulation RAC2 TNF 22965143 2706258 *stimulated* [Rac] activation and reactive oxygen species production in a P-Rex1 dependent manner . Positive_regulation RAC2 TNF 23389627 2759186 Taken together , our findings can explain the mechanisms leading to hierarchical *activation* of [Rac] and RhoA by through a single GEF . Positive_regulation RAC2 WNT7A 15802269 1410473 induced the accumulation of beta-catenin and the activation of Rac and beta-catenin , and [Rac] synergistically *induced* the transcription of MMP-12 . Positive_regulation RAC3 CAPN8 11062268 746676 In contrast , while [Rac-] and Rho-GTPases were *dependent* on for their activation , formation of focal complexes and focal adhesions by constitutively active Rac or Rho , respectively , occurred even when calpain inhibitors were present . Positive_regulation RAC3 CCND1 19765988 2140734 In contrast , FAK dependent [Rac] activation , Rac dependent gene *induction* , and cyclin D1-dependent Rb phosphorylation are strongly inhibited at physiological tissue stiffness and rescued when the matrix is stiffened in vitro . Positive_regulation RAC3 IL1B 20231290 2254615 PTX induced biphasic increases in Rac activity , and the Rac activation in a late but not an early phase was suppressed by IL-1beta siRNA , suggesting that *induced* [Rac] activation contributes to the amplification of Rac dependent signaling induced by PTX . Positive_regulation RAC3 ITGB2 14960575 1227767 We have identified Vav , a guanine nucleotide exchange factor for Rac-1 , and PI3K/Akt , as regulators of the activation and inactivation phases of the activity of Rac-1 , respectively , in the context of LFA-1 signaling based on the following experimental evidence : ( i ) LFA-1 induced activation of Vav and PI3K/Akt with kinetics consistent with a regulatory role for these molecules on Rac-1 , ( ii ) overexpression of a constitutively active Vav mutant induces activation of Rac independently of LFA-1 stimulation whereas overexpression of a dominant negative Vav mutant blocks mediated [Rac] *activation* , ( iii ) pharmacological inhibition of PI3K/Akt prevented the fall in the activity of Rac-1 after its initial activation but had no effect on Vav activity , and ( iv ) overexpression of a dominant negative or a constitutively active Akt-1 induced or inhibited , respectively , Rac-1 activity . Positive_regulation RAC3 NEDD9 22328516 2592252 interacts with the guanine nucleotide exchange factor DOCK3 to *promote* [Rac] activation and the elongated , mesenchymal-type of tumour cell invasion , but the molecular mechanisms through which NEDD9 promotes melanoma metastasis are not fully understood . Positive_regulation RAC3 S1PR3 12069818 955558 Consistent with this , Edg1 and , and Edg5 *regulate* the activity of the Rho family GTPase [Rac] positively and negatively , respectively . Positive_regulation RAC3 S1PR3 12588974 1059729 In contrast to S1P2 , *mediated* S1P directed , pertussis toxin-sensitive chemotaxis and [Rac] activation despite concurrent stimulation of Rho via G12/13 . Positive_regulation RAC3 TNF 11453646 837060 Using the Rac binding domain of PAK ( PAK-RBD ) as an activation-specific probe , here we demonstrate that very rapidly and transiently *activates* the Rho family GTPase [Rac] in L929 cells . Positive_regulation RAC3 TNF 18258304 1884811 This would suggest that *induced* activation of [Rac] , lies upstream of NF-kappaB activation , and that the inhibition of this pathway results in inhibition of cytokine production . Positive_regulation RAC3 TNF 19473519 2091161 TNF-alpha induced phosphorylation of Rac , while atorvastatin and Rac-1 inhibitor inhibited the phosphorylation of [Rac] *induced* by . Positive_regulation RAC3 TNF 20805415 2324608 Enhanced Rac activation and phagocytosis following IFN-? priming were dependent on NO production via inducible NO synthase and activation of protein kinase G. Notably , endogenous production of in response to IFN-? priming was critically *required* for inducible NO synthase upregulation , NO production , [Rac] activation , and enhanced phagocytosis . Positive_regulation RAC3 TNF 22965143 2706259 *stimulated* [Rac] activation and reactive oxygen species production in a P-Rex1 dependent manner . Positive_regulation RAC3 TNF 23389627 2759187 Taken together , our findings can explain the mechanisms leading to hierarchical *activation* of [Rac] and RhoA by through a single GEF . Positive_regulation RAC3 WNT7A 15802269 1410476 induced the accumulation of beta-catenin and the activation of Rac and beta-catenin , and [Rac] synergistically *induced* the transcription of MMP-12 . Positive_regulation RAD1 EPHB2 24416349 2900831 Intriguingly , inhibitors PD98059 and U0126 *suppressed* [RAD001] plus MK-2206 induced beclin-1 expression , autophagy induction and cytotoxicity in HGC-27 cells . Positive_regulation RAD1 MAP2K6 24416349 2900837 Intriguingly , inhibitors PD98059 and U0126 *suppressed* [RAD001] plus MK-2206 induced beclin-1 expression , autophagy induction and cytotoxicity in HGC-27 cells . Positive_regulation RAD17 EPHB2 24416349 2900839 Intriguingly , inhibitors PD98059 and U0126 *suppressed* [RAD001] plus MK-2206 induced beclin-1 expression , autophagy induction and cytotoxicity in HGC-27 cells . Positive_regulation RAD17 MAP2K6 24416349 2900845 Intriguingly , inhibitors PD98059 and U0126 *suppressed* [RAD001] plus MK-2206 induced beclin-1 expression , autophagy induction and cytotoxicity in HGC-27 cells . Positive_regulation RAD18 EPHB2 24416349 2900823 Intriguingly , inhibitors PD98059 and U0126 *suppressed* [RAD001] plus MK-2206 induced beclin-1 expression , autophagy induction and cytotoxicity in HGC-27 cells . Positive_regulation RAD18 MAP2K6 24416349 2900829 Intriguingly , inhibitors PD98059 and U0126 *suppressed* [RAD001] plus MK-2206 induced beclin-1 expression , autophagy induction and cytotoxicity in HGC-27 cells . Positive_regulation RAD21 EPHB2 24416349 2900847 Intriguingly , inhibitors PD98059 and U0126 *suppressed* [RAD001] plus MK-2206 induced beclin-1 expression , autophagy induction and cytotoxicity in HGC-27 cells . Positive_regulation RAD21 MAP2K6 24416349 2900853 Intriguingly , inhibitors PD98059 and U0126 *suppressed* [RAD001] plus MK-2206 induced beclin-1 expression , autophagy induction and cytotoxicity in HGC-27 cells . Positive_regulation RAD50 EPHB2 12402047 1009426 We conclude that cAMP induced regulation of and *activation* of [Rap1] are independent processes . Positive_regulation RAD50 EPHB2 15178807 1280493 TPA treatment rapidly increased phosphorylation of , a reported downstream effector of both PKC and Rap1 , in ERC-18 cells , but induced weak [Rap1] *activation* . Positive_regulation RAD50 EPHB2 24416349 2900855 Intriguingly , inhibitors PD98059 and U0126 *suppressed* [RAD001] plus MK-2206 induced beclin-1 expression , autophagy induction and cytotoxicity in HGC-27 cells . Positive_regulation RAD50 F2R 15078882 1251884 We found that , similarly to thrombin , selective stimulation of either or PAR-4 by specific activating peptides *caused* accumulation of GTP bound [Rap1B] in a dose dependent manner . Positive_regulation RAD50 F2R 15078882 1251898 In the presence of the ADP scavengers apyrase or phosphocreatine-phosphocreatine kinase , activation of [Rap1B] *induced* by stimulation of either or PAR-4 was totally inhibited . Positive_regulation RAD50 F2R 15078882 1251926 Concomitant stimulation of both and PAR-4 in the presence of ADP scavengers still *resulted* in a strongly reduced activation of [Rap1B] . Positive_regulation RAD50 F2R 19483102 2107935 Perturbation of PI3K signaling by isoform-selective inhibitors had differential effects on [Rap1] *activation* through and PAR4 . Positive_regulation RAD50 F2R 24790104 2950507 Stimulation of the G-protein coupled receptor with thrombin in human 1321N1 glioblastoma cells *led* to a robust increase in [Rap1] activation . Positive_regulation RAD50 FLG 17045653 1666580 Using a Rap1-GTP pull-down assay , we found that stimulation , but not LPS , of avian heterophils *induced* a rapid and transient [Rap1] activation . Positive_regulation RAD50 FLG 17045653 1666601 We show here that stimulation of heterophils *induces* the phosphorylation of [Rap1] . Positive_regulation RAD50 ITGAL 24486015 2928147 The gap junction protein connexin43 (Cx43) regulates B lymphocyte adhesion , BCR- and mediated *activation* of the GTPase [Rap1] , and cytoskeletal rearrangements resulting in changes to cell shape and membrane spreading . Positive_regulation RAD50 MAP2K6 24416349 2900861 Intriguingly , inhibitors PD98059 and U0126 *suppressed* [RAD001] plus MK-2206 induced beclin-1 expression , autophagy induction and cytotoxicity in HGC-27 cells . Positive_regulation RAD50 PECAM1 10725328 677543 Importantly , selectively *activated* the small Ras related GTPase , [Rap1] , but not Ras , R-Ras , or Rap2 . Positive_regulation RAD50 TNF 16043520 1437852 Both compounds blocked induced *activation* of [Rap1A] , a phox associated guanosine triphosphatase that is regulated by cAMP . Positive_regulation RAD51 CCND1 21654808 2442179 We found that cyclin D1 directly binds [RAD51] , and that interaction is *induced* by radiation . Positive_regulation RAD51 CCND1 24830723 2945120 was recruited to ?H2AX foci by E2 and *induced* [Rad51] expression . Positive_regulation RAD51 EPHB2 24416349 2900863 Intriguingly , inhibitors PD98059 and U0126 *suppressed* [RAD001] plus MK-2206 induced beclin-1 expression , autophagy induction and cytotoxicity in HGC-27 cells . Positive_regulation RAD51 MAP2K6 18544565 1945821 Enhancement of ERK1/2 signaling by constitutively active 1/2 ( MKK1/2-CA ) *increased* [Rad51] protein levels and protein stability in gefitinib and cisplatin or MMC cotreated cells . Positive_regulation RAD51 MAP2K6 24416349 2900869 Intriguingly , inhibitors PD98059 and U0126 *suppressed* [RAD001] plus MK-2206 induced beclin-1 expression , autophagy induction and cytotoxicity in HGC-27 cells . Positive_regulation RAD52 EPHB2 24416349 2900871 Intriguingly , inhibitors PD98059 and U0126 *suppressed* [RAD001] plus MK-2206 induced beclin-1 expression , autophagy induction and cytotoxicity in HGC-27 cells . Positive_regulation RAD52 MAP2K6 24416349 2900877 Intriguingly , inhibitors PD98059 and U0126 *suppressed* [RAD001] plus MK-2206 induced beclin-1 expression , autophagy induction and cytotoxicity in HGC-27 cells . Positive_regulation RAE1 NES 9371762 466146 A functional is *required* for active export , presumably by interacting directly or indirectly with the [nuclear pore complex] . Positive_regulation RAF1 CLU 19218870 2039560 Exogenous *stimulates* Ras dependent [Raf-1/mitogen] activated protein kinase kinase ( MEK ) /ERK activation . Positive_regulation RAF1 EDN2 17707940 1800754 Endothelin induced ERK phosphorylation was independent of integrin ligands , and an inhibitor of G ( q/11 ) , YM-254890 , as well as pertussis toxin , partially inhibited *stimulated* phosphorylation of [Raf-1] and ERK . Positive_regulation RAF1 EDN2 8340422 226131 [c-Raf-1] activation is also *induced* by insulin , phorbol ester , thrombin , and . Positive_regulation RAF1 EDN2 8621441 359469 The activity of Raf-1 , measured by immune complex kinase assay , revealed that platelet derived growth factor and phorbol 12-myristate 13-acetate both stimulated Raf-1 activity , while thrombin and did not appreciably *stimulate* [Raf-1] . Positive_regulation RAF1 EPHB2 10376521 623372 Taxol induced apoptosis was associated with phosphorylation of both [c-Raf-1] and Bcl-2 and *activation* of and JNK MAP kinases . Positive_regulation RAF1 EPHB2 11088001 764969 We show that the activation of via SSTR1 is mediated by the betagamma subunit of a pertussis toxin-sensitive G-protein and *requires* both the small G protein Ras and the serine/threonine kinase [Raf-1] . Positive_regulation RAF1 EPHB2 14670956 1210976 PKC/PKC alpha activity promoted GTP loading of Ras , *activation* of [Raf-1] , and phosphorylation/activation of . Positive_regulation RAF1 EPHB2 15009680 1217867 Activation of this conditionally active form of [Raf-1] *induced* a sustained phosphorylation of , and protected the cells from serum withdrawal induced cell death . Positive_regulation RAF1 EPHB2 18335053 1881510 We found that the pathway structure is characterized by *mediated* positive feedback regulation of B-Raf and B-Raf mediated negative regulation of [Raf-1] . Positive_regulation RAF1 EPHB2 23118896 2696019 *Activation* of by active [c-Raf] was also prevented by RanBPM . Positive_regulation RAF1 EPHB2 24284076 2904575 *Activation* of and RSK signaling by the expression of constitutively active [RAF1] suppresses the mutant phenotype in a RSK dependent manner . Positive_regulation RAF1 EPHB2 9892010 586576 We show that the activation of via SSTR1 is pertussis toxin sensitive and *requires* the small G protein Ras , phosphatidylinositol 3-kinase , the serine/threonine kinase [Raf-1] , and the protein tyrosine phosphatase SHP-2 . Positive_regulation RAF1 FAS 15282307 1277710 c-Flip , along with Raf-1 , is part of a K8/K18 immunoisolated complex from wild-type hepatocytes , and stimulation *leads* to further c-Flip and [Raf-1] recruitment in the complex . Positive_regulation RAF1 FAS 16365167 1493222 activation *stimulates* the formation of [Raf-1-Rok-alpha] complexes , and Rok-alpha signaling is up-regulated in Raf-1-deficient cells . Positive_regulation RAF1 FAS 20658220 2316955 To distinguish between the activation signalling and the death inducing pathway downstream of Fas , we generated a novel T cell line expressing a chimeric hCD8-FasC protein and found that stimulation with the anti-CD8 antibodies *induced* tyrosine phosphorylation of TCR-proximal proteins , activation of [Raf-1/ERK] , p38 and JNK , and increased expression of CD69 , , and Fas ligand . Positive_regulation RAF1 ID1 14742319 1250773 Using four stable Id-1 transfectant clones , we found that exogenous expression *led* to phosphorylation of [Raf-1] and MEK1/2 kinases , which was associated with resistance to taxol . Positive_regulation RAF1 MAP2K6 11296227 801455 kinase activity is not *necessary* for [Raf-1] function . Positive_regulation RAF1 MAP2K6 11478855 842110 Phosphorylation of [raf-1] by kinase suppressor of ras is *inhibited* by <"MEK-specific> '' inhibitors PD 098059 and U0126 in differentiating HL60 cells . Positive_regulation RAF1 MAP2K6 12417593 1036336 The increase in MAPK activity and tyrosine phosphorylation caused by 1alpha,25 ( OH ) ( 2 ) D ( 3 ) could be abolished by Ras inhibitor peptide , compound PD 98059 , which prevents the *activation* of by [Raf-1] , or incubation of cell lysates before 1alpha,25 ( OH ) ( 2 ) D ( 3 ) exposure with an anti-Raf-1 antibody . Positive_regulation RAF1 MAP2K6 19197339 2044043 Consistent with the properties of a scaffold , PEBP4 enhances the [RAF1-MEK] interaction and the *activation* of at low expression levels , whereas it inhibits these parameters at higher expression levels . Positive_regulation RAF1 MAP2K6 20028985 2210948 Raf kinase inhibitor protein (RKIP) inhibits *activation* of by [Raf-1] and its downstream signal transduction , resulting in blocking the MAP kinase pathway . Positive_regulation RAF1 MAP2K6 8413257 233837 We conclude that MEK is a direct substrate of Raf-1 and that the *activation* of by [Raf-1] is due to phosphorylation by Raf-1 , which is sufficient for MEK activation . Positive_regulation RAF1 STK39 1645717 157825 Phosphorylation of the [RAF-1] protooncogene product and *activation* of its associated are common features of the response of cells to peptide growth factors . Positive_regulation RAF1 STK39 3057494 100823 These findings suggest that proliferative signals generated at the membrane result in the phosphorylation of the [Raf-1] protein and the *activation* of its activity . Positive_regulation RAF1 TNF 11221891 787474 Furthermore , *induced* [Raf-1] threonine phosphorylation , kinase activity toward MEK1 , and association with KSR are also inhibited by kiKSR expression . Positive_regulation RAF1 TNF 11221891 787476 Our data also show by sequential in vitro kinase assays that *enhances* KSR phosphorylation of [Raf-1] on threonine , enhancing Raf-1 kinase activity toward MAP kinase kinase . Positive_regulation RAF1 TNF 12010819 941319 Addition of GM-CSF , but not , *increased* phosphorylation of both [Raf-1] and the mitogen activated protein kinases ( MAPKs ) JNK-1 and ERK-1 . Positive_regulation RAF1 TNF 17031853 1683076 Taken together , these findings indicate that Raf-1/MEK/ERK signaling pathway plays a crucial role in the production of MMP-1 in HCS-2/8 cells in response to TNF-alpha , and that the produced PGE ( 2 ) downregulates the expression of MMP-1 by blockage of *induced* [Raf-1] activation through EP4-PGE ( 2 ) receptor activation . Positive_regulation RAF1 TNF 7790814 313273 Using an enzyme linked immunosorbent assay for murine tumor necrosis factor alpha (TNF-alpha) , we found that LPS and PMA stimulation and delta [Raf-1] : ER activation *induced* secretion of , although the amount of TNF-alpha secreted in response to delta Raf-1 : ER activation and PMA stimulation was approximately 20-fold less than that secreted in response to LPS . Positive_regulation RAF1 TNF 7929360 274501 also produces a small and transient *increase* in extracellular signal regulated kinase ( ERK ) activity and no measured increase in [Raf-1] kinase activity . Positive_regulation RAF1 TNF 9766635 538475 GM-CSF , but not , *stimulated* wortmannin-sensitive activation of [Raf-1] . Positive_regulation RAG1 FOXO1 18469817 1916594 Foxo1 directly activated transcription of the Rag1-Rag2 locus throughout early B cell development , and a decrease in protein *diminished* the induction of [Rag1] and Rag2 transcription in a model of receptor editing . Positive_regulation RAG1 FOXO1 20709952 2312828 However , whereas the PI(3)K/Akt regulation of [Rag] transcription is *mediated* by , we show in this study that the MEK/ERK pathway coordinates with the regulation of Rag by controlling the phosphorylation and turnover of E47 and its consequential binding to the Rag enhancer regions . Positive_regulation RAG1 FOXO1 21655267 2442292 Over-expression of E2A , or Foxp1 *increased* [RAG] expression , while RNA interference of E2A , FOXO1 or FOXP1 decreased RAG expression in the cancer cells . Positive_regulation RAG1 FOXO1 24614102 2930037 Specifically , CDK4 phosphorylated and inactivated FOXO1 , which prevented *dependent* induction of [Rag1] and Rag2 transcription . Positive_regulation RAG1 ZFP57 17057722 1642121 Overexpression of in BALB/c thymocytes substantially *impaired* [Rag1] and Rag2 expression , indicating the underlying mechanism for the defect in ZORI thymocyte development . Positive_regulation RAG2 FOXO1 18469817 1916595 Foxo1 directly activated transcription of the [Rag1-Rag2] locus throughout early B cell development , and a decrease in protein *diminished* the induction of Rag1 and Rag2 transcription in a model of receptor editing . Positive_regulation RAG2 FOXO1 20709952 2312829 However , whereas the PI(3)K/Akt regulation of [Rag] transcription is *mediated* by , we show in this study that the MEK/ERK pathway coordinates with the regulation of Rag by controlling the phosphorylation and turnover of E47 and its consequential binding to the Rag enhancer regions . Positive_regulation RAG2 FOXO1 21655267 2442294 Over-expression of E2A , or Foxp1 *increased* [RAG] expression , while RNA interference of E2A , FOXO1 or FOXP1 decreased RAG expression in the cancer cells . Positive_regulation RAG2 FOXO1 24614102 2930038 Specifically , CDK4 phosphorylated and inactivated FOXO1 , which prevented dependent *induction* of Rag1 and [Rag2] transcription . Positive_regulation RAG2 ZFP57 17057722 1642139 Overexpression of in BALB/c thymocytes substantially *impaired* Rag1 and [Rag2] expression , indicating the underlying mechanism for the defect in ZORI thymocyte development . Positive_regulation RAI1 IL1B 16959849 1639684 The decrease in [retinoic acid induced] renin promoter activity in *response* to was blocked with the general tyrosine kinase inhibitor Genistein . Positive_regulation RAI1 TGM2 11350930 814740 *Role* of in [retinoic acid induced] activation of RhoA associated kinase-2 . Positive_regulation RAI1 TGM2 11854287 929324 Phosphoinositide 3-kinase activity is required for [retinoic acid induced] expression and *activation* of the . Positive_regulation RAI1 TGM2 2900242 95471 The [retinoic acid induced] increase in tissue transglutaminase mRNA is independent of concurrent protein synthesis and is *due* to an increased transcription of the gene . Positive_regulation RAI14 IL1B 16959849 1639683 The decrease in [retinoic acid induced] renin promoter activity in *response* to was blocked with the general tyrosine kinase inhibitor Genistein . Positive_regulation RAI14 TGM2 11350930 814739 *Role* of in [retinoic acid induced] activation of RhoA associated kinase-2 . Positive_regulation RAI14 TGM2 11854287 929323 Phosphoinositide 3-kinase activity is required for [retinoic acid induced] expression and *activation* of the . Positive_regulation RAI14 TGM2 2900242 95470 The [retinoic acid induced] increase in tissue transglutaminase mRNA is independent of concurrent protein synthesis and is *due* to an increased transcription of the gene . Positive_regulation RAI2 IL1B 16959849 1639685 The decrease in [retinoic acid induced] renin promoter activity in *response* to was blocked with the general tyrosine kinase inhibitor Genistein . Positive_regulation RAI2 TGM2 11350930 814741 *Role* of in [retinoic acid induced] activation of RhoA associated kinase-2 . Positive_regulation RAI2 TGM2 11854287 929325 Phosphoinositide 3-kinase activity is required for [retinoic acid induced] expression and *activation* of the . Positive_regulation RAI2 TGM2 2900242 95472 The [retinoic acid induced] increase in tissue transglutaminase mRNA is independent of concurrent protein synthesis and is *due* to an increased transcription of the gene . Positive_regulation RALA EPHB2 9774335 539657 We have investigated which extracellular signals can activate Rap1 and whether this activation leads to a modulation of Ras effector signalling , i.e. the *activation* of and the small GTPase [Ral] . Positive_regulation RALA HBEGF 21179550 2358301 [RAL] *induced* the expression of active and erbB1 . Positive_regulation RAN NES 15020682 1221564 CRM1 and [Ran] are present but a complex is not *required* in Balbiani ring mRNP particles from the gene to the cytoplasm . Positive_regulation RANBP2 CD14 15834312 1394715 These data indicate that functional TLR4 and are *required* for [NPC] production of cytokines and that at least one of the critical components from hepatocytes is LBP . Positive_regulation RANBP2 IFI27 12490316 1033150 To clarify the *roles* of and c-myc in [nasopharyngeal carcinoma (NPC)] , we used immunohistochemical studies to examine the expression of p27 and c-myc proteins in 69 patients with NPC . Positive_regulation RANBP2 MUC16 19068094 2182175 The results showed that HSP70 and 5B expression *increased* not only in rat [NPC] but also in atypical hyperplasia nasopharyngeal tissues , a precancer stage of NPC . Positive_regulation RANBP2 NES 9371762 466147 A functional is *required* for active export , presumably by interacting directly or indirectly with the [nuclear pore complex] . Positive_regulation RANBP2 STK39 18083840 1837422 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation RANBP9 EPHB2 12147692 985223 We show that [RanBPM] can *induce* GTP-Ras association and phosphorylation and elevate serum response element-luciferase ( SRE-LUC ) expression , indicating that RanBPM can activate the Ras-Erk-SRE pathway . Positive_regulation RANGAP1 STK39 18083840 1837437 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation RAP1A ITGB2 11165259 782771 These results suggest that CD98 cross linking activates via the PI3K signaling pathway and *induces* accumulation of [Rap1GTP] in a LFA-1 dependent manner , which in turn mediates the cytoskeleton dependent cell adhesion process . Positive_regulation RAP2A PECAM1 10725328 677544 Importantly , selectively *activated* the small Ras related GTPase , Rap1 , but not Ras , R-Ras , or [Rap2] . Positive_regulation RAPGEF2 EPHB2 17724123 1789771 Thus , the interaction of [PDZ-GEF1] with an internalized neurotrophin receptor transported to late endosomes *induces* sustained activation of both Rap1 and and neurite outgrowth . Positive_regulation RAPGEF4 GLP1R 23542788 2777712 Cardiomyocyte activation *promoted* the translocation of the Rap guanine nucleotide exchange factor [Epac2] ( also known as Rapgef4 ) to the membrane , whereas Epac2 deficiency eliminated GLP-1R dependent stimulation of ANP secretion . Positive_regulation RARA EPHB2 18445086 1921212 To our knowledge , this is the first report to show that [PML/RARalpha] was *suppressed* by inhibition , through a mechanism dependent on caspase activation . Positive_regulation RARA IL1B 12105223 976676 How signaling *leads* to reduced [RXR:RAR] nuclear binding activity is unknown , and we sought to determine whether mitogen activated protein kinase (MAPK) pathways were involved . Positive_regulation RARA MAP2K6 18445086 1921218 To our knowledge , this is the first report to show that [PML/RARalpha] was *suppressed* by inhibition , through a mechanism dependent on caspase activation . Positive_regulation RARA RARB 10629091 659423 Transcription of the retinoic receptor beta ( ) gene is *activated* in a ligand dependent manner by the [retinoic acid receptor alpha] . Positive_regulation RARA RARB 10999756 734347 Lung [RARalpha] was *induced* by 4.7-fold , by 8.0-fold , and RARgamma by 8.1-fold . Positive_regulation RARA RARB 12921748 1130995 expression *requires* the expression of [RARalpha2] . Positive_regulation RARA RARB 8689531 372589 In 12-day-old conceptuses exposed to all-trans-retinoic acid , [RAR alpha] did not increase significantly , but *increased* 12-fold at 4 hr and RAR gamma 2-fold at 1 hr after the maternal treatments . Positive_regulation RARB ACR 19520494 2149476 These results suggest that and VPA cooperatively *increase* the expression of [RARbeta] and p21 ( CIP1 ) , while inhibiting the phosphorylation of RXRalpha , and these effects were associated with induction of apoptosis and the inhibition of cell growth in HepG2 cells . Positive_regulation RARB ADH4 8309781 241153 In addition , [Ra/Rb] was significantly *increased* by ( 4.6 +/- 0.5 to 10.2 +/- 3.6 ) . Positive_regulation RARB ADH5 8309781 241154 In addition , [Ra/Rb] was significantly *increased* by ( 4.6 +/- 0.5 to 10.2 +/- 3.6 ) . Positive_regulation RARB ADH6 8309781 241155 In addition , [Ra/Rb] was significantly *increased* by ( 4.6 +/- 0.5 to 10.2 +/- 3.6 ) . Positive_regulation RARB ADH7 8309781 241156 In addition , [Ra/Rb] was significantly *increased* by ( 4.6 +/- 0.5 to 10.2 +/- 3.6 ) . Positive_regulation RARB AKR1C4 12529992 1028376 In conclusion , [RAR beta] 2 can be *activated* in vitro by <5-Aza-CdR> , which may be one of the mechanisms for the tumor cell growth inhibition by 5-Aza-CdR . Positive_regulation RARB AKR1C4 9147612 419619 We also observed that <5-Aza-CdR> , a potent inhibitor of DNA methylation , *increased* the expression of [retinoic acid receptor (RAR)-beta] . Positive_regulation RARB AKR1C4 9147612 419620 In an attempt to clarify the mechanism responsible for the *activation* of the [RAR-beta] gene by <5-Aza-CdR> in DLD-1 colon carcinoma cells , we investigated its methylation state by Southern blotting . Positive_regulation RARB CAT 11358817 816130 Furthermore , induction with all of the compounds was accompanied by up-regulation of mRNA levels of the nuclear [retinoic acid receptor beta (RARbeta)] and specific *activation* of a reporter gene construct ( ) that contains the canonical RA response element located in the RARbeta promoter . Positive_regulation RARB CCNC 1850112 155502 or a similar protein , however , does *enhance* binding of [retinoic acid receptor-beta] to a hormone response element . Positive_regulation RARB CDA 20447390 2268436 In MDA-MB-231 cells , only <2CdA> , F-ara-A , and ATRA *induced* [RAR beta] 2 expression without any notable effects in combined treatment . Positive_regulation RARB CDKN1A 12516107 1039278 Ectopic gene transfer *induces* [retinoic acid receptor beta] expression and sensitizes human cancer cells to retinoid treatment . Positive_regulation RARB CDKN1A 12516107 1039279 We show that recombinant adenovirus mediated ( sdi1 ) gene transfer *enhances* [RARbeta] mRNA expression as well as protein expression and induces the sensitivity to all-trans RA ( ATRA ) in human cancer cells . Positive_regulation RARB CDKN1A 15026551 1222789 Acyclic retinoid activates [retinoic acid receptor beta] and *induces* transcriptional activation of ( CIP1 ) in HepG2 human hepatoma cells . Positive_regulation RARB CISH 10234809 611641 All-trans-retinoic acid ( tRA ) or <13-cis-RA> *increased* [RAR beta] and decreased K1 and TGase I mRNA levels in serum-free medium . Positive_regulation RARB CISH 9751509 533607 Similar to ATRA , <9-cis-RA> transiently *induced* the messenger RNA expression of the nuclear RA receptor [RAR beta] , suggesting a role for this receptor in the effects of retinoids on the differentiation and proliferation of A spermatogonia . Positive_regulation RARB CYP26A1 20231276 2254511 Hoxa1 and transcripts are not expressed , but [RARbeta] ( 2 ) transcripts are *induced* by RA in mouse embryonic fibroblasts and Balb/c3T3 cells . Positive_regulation RARB DKC1 14586406 1159581 Our previous work showed that acquisition of immortality at the dysplasia stage of oral cancer progression was consistently associated with four changes : loss of [retinoic acid receptor (RAR)-beta] and p16INK4A expression , p53 mutations and *activation* of . Positive_regulation RARB FGF10 16427040 1534042 We show that activation of [RAR beta] , but not alpha , *induces* expression of the fibroblast growth factor and bud morphogenesis in the lung field . Positive_regulation RARB GGA1 16165408 1517377 Moreover , RA , GGOH and all *stimulated* [RARbeta] mRNA expression in bone explants . Positive_regulation RARB GGA2 16165408 1517375 Moreover , RA , GGOH and all *stimulated* [RARbeta] mRNA expression in bone explants . Positive_regulation RARB GGA3 16165408 1517376 Moreover , RA , GGOH and all *stimulated* [RARbeta] mRNA expression in bone explants . Positive_regulation RARB HOXA1 20231276 2254512 and Cyp26a1 transcripts are not expressed , but [RARbeta] ( 2 ) transcripts are *induced* by RA in mouse embryonic fibroblasts and Balb/c3T3 cells . Positive_regulation RARB HPR 10328240 612930 Our results demonstrate that basal expression and <4HPR> *inducibility* of [RARbeta] play a role in mediating 4HPR response in ovarian cancer cells . Positive_regulation RARB HPR 11176527 784346 All-trans-retinoic acid and <4HPR> *induced* [retinoic acid receptor beta] expression in 1 bladder cancer cell line . Positive_regulation RARB HPR 14676128 1178907 Finally , 4HPR repression of angiogenesis was associated with a <4HPR> *induced* increase in [retinoic acid receptor beta] expression . Positive_regulation RARB HSP90AA1 14586406 1159582 Our previous work showed that acquisition of immortality at the dysplasia stage of oral cancer progression was consistently associated with four changes : loss of [retinoic acid receptor (RAR)-beta] and p16INK4A expression , p53 mutations and *activation* of . Positive_regulation RARB IFNG 10863413 580422 ATRA ( 1 microM ) and ( 1000 u/mL ) *increased* [RAR beta] expression to 4 times and 3 times , respectively . Positive_regulation RARB IGF1 10498893 647744 In this study we show that and tetradecanoyl phorbol acetate ( TPA ) *induce* [RARbeta] gene expression in neuroblastoma SH-SY5Y cells . Positive_regulation RARB IGF1 10498893 647745 and TPA *caused* a marked induction of [RARbeta2] promoter activity and had a synergistic effect with RA that also upregulates transcription . Positive_regulation RARB IL1B 11171635 784065 IL-1beta and/or RA did not change the type 1 IL-1 receptor transcript level , whereas *enhanced* the RA-induced expressions of [retinoic acid receptor-beta (RAR-beta)] and retinoid X receptor-beta (RXR-beta) mRNAs and RA-mediated RXR response element binding . Positive_regulation RARB MED1 1850112 155514 or a similar protein , however , does *enhance* binding of [retinoic acid receptor-beta] to a hormone response element . Positive_regulation RARB MED10 1850112 155513 or a similar protein , however , does *enhance* binding of [retinoic acid receptor-beta] to a hormone response element . Positive_regulation RARB MED12 1850112 155501 or a similar protein , however , does *enhance* binding of [retinoic acid receptor-beta] to a hormone response element . Positive_regulation RARB MED13 1850112 155506 or a similar protein , however , does *enhance* binding of [retinoic acid receptor-beta] to a hormone response element . Positive_regulation RARB MED14 1850112 155509 or a similar protein , however , does *enhance* binding of [retinoic acid receptor-beta] to a hormone response element . Positive_regulation RARB MED16 1850112 155503 or a similar protein , however , does *enhance* binding of [retinoic acid receptor-beta] to a hormone response element . Positive_regulation RARB MED17 1850112 155510 or a similar protein , however , does *enhance* binding of [retinoic acid receptor-beta] to a hormone response element . Positive_regulation RARB MED21 1850112 155499 or a similar protein , however , does *enhance* binding of [retinoic acid receptor-beta] to a hormone response element . Positive_regulation RARB MED24 1850112 155507 or a similar protein , however , does *enhance* binding of [retinoic acid receptor-beta] to a hormone response element . Positive_regulation RARB MED27 1850112 155511 or a similar protein , however , does *enhance* binding of [retinoic acid receptor-beta] to a hormone response element . Positive_regulation RARB MED31 1850112 155512 or a similar protein , however , does *enhance* binding of [retinoic acid receptor-beta] to a hormone response element . Positive_regulation RARB MED4 1850112 155504 or a similar protein , however , does *enhance* binding of [retinoic acid receptor-beta] to a hormone response element . Positive_regulation RARB MED6 1850112 155505 or a similar protein , however , does *enhance* binding of [retinoic acid receptor-beta] to a hormone response element . Positive_regulation RARB NAPA 7829265 293441 We have determined that can markedly *enhance* mRNA levels of the nuclear [RA receptor-beta (RAR beta)] in LA-N-5 cells prior to morphologic or other phenotypic changes induced by this compound . Positive_regulation RARB NAPA 9511735 491982 Taken together , our findings suggest that *induction* of [RAR beta] by is regulated at the level of transcription and mediated through the retinoic acid response element , RARE beta . Positive_regulation RARB NGF 11158236 781015 *activates* the [RARbeta2] promoter by a Ras dependent mechanism . Positive_regulation RARB NGF 11158236 781016 These results suggest that the RARbeta2 gene could be in a basal repressed state and could *increase* [RARbeta2] transcription by inducing the release of some inhibitory factors from the INR . Positive_regulation RARB NGF 11158236 781017 Functional Ras is required for [RARbeta2] promoter *activation* by because expression of oncogenic Ras increases promoter activity and a dominant inhibitory Ras mutant blocks the effect of NGF . Positive_regulation RARB NR2C1 10766818 684502 Constitutive *activation* of [retinoic acid receptor beta2] promoter by . Positive_regulation RARB NR2C1 10766818 684503 The functions as a constitutive *activator* for the endogenous [retinoic acid receptor beta2] ( RAR ( beta2 ) ) gene expression in P19 embryonal carcinoma cells and for reporters driven by the RAR ( beta2 ) promoter in COS-1 cells . Positive_regulation RARB NR2F2 22693611 2615579 Functional interaction between COUP-TFII and nucleolin was indicated by studies showing that siRNA knockdown of nucleolin and an oligonucleotide aptamer that targets nucleolin , AS1411 , inhibited endogenous *stimulated* [RARB2] expression in MCF-7 and T47D cells . Positive_regulation RARB NRGN 16115698 1581684 Results showed that 12 % ethanol consumption in adult mice ( 11 months ) *induced* an increase in [RARbeta] , RXRbetagamma and TRalphabeta mRNA level in the brain with only an increase in expression . Positive_regulation RARB PLAT 8695801 372856 Stimulation of expression by retinoic acid in human endothelial cells *requires* [retinoic acid receptor beta] 2 induction . Positive_regulation RARB PRDX2 11488527 845247 alone only *activated* [RAR beta] , but not ER alpha . Positive_regulation RARB PTGES3 14586406 1159580 Our previous work showed that acquisition of immortality at the dysplasia stage of oral cancer progression was consistently associated with four changes : loss of [retinoic acid receptor (RAR)-beta] and p16INK4A expression , p53 mutations and *activation* of . Positive_regulation RARB PTGS2 16170369 1489110 Benzo [ a ] pyrene diol epoxide ( BPDE , a carcinogen present in tobacco smoke and environmental pollution ) has been shown to suppress [retinoic acid receptor-beta2] ( RAR-beta ( 2 ) ) and *induce* expression . Positive_regulation RARB RAI1 11454993 837901 After exposure to 5-aza-2prime ; -deoxycytidine treatment , Trichostatin A and all-trans partial demethylation , increased accumulation of acetylated histones , and markedly *restored* the expression of [RARbeta2] in RARbeta2 negative cells . Positive_regulation RARB RAI1 7565739 324668 We now show that direct interaction between RAR and E1A is a requirement for [RAR beta] 2 *activation* . Positive_regulation RARB RAI1 8670275 369656 The retinoid , however , exhibited concentration dependent inhibitory effects on the basal level of transcriptional activity ( no other retinoid added ) of both the [RAR beta-] and RARgamma/RXRalpha heterodimers and of the transcriptional *activation* of the RARgamma/RXRalpha receptors . Positive_regulation RARB RAI14 11454993 837900 After exposure to 5-aza-2prime ; -deoxycytidine treatment , Trichostatin A and all-trans partial demethylation , increased accumulation of acetylated histones , and markedly *restored* the expression of [RARbeta2] in RARbeta2 negative cells . Positive_regulation RARB RAI14 7565739 324667 We now show that direct interaction between RAR and E1A is a requirement for [RAR beta] 2 *activation* . Positive_regulation RARB RAI14 8670275 369655 The retinoid , however , exhibited concentration dependent inhibitory effects on the basal level of transcriptional activity ( no other retinoid added ) of both the [RAR beta-] and RARgamma/RXRalpha heterodimers and of the transcriptional *activation* of the RARgamma/RXRalpha receptors . Positive_regulation RARB RAI2 11454993 837902 After exposure to 5-aza-2prime ; -deoxycytidine treatment , Trichostatin A and all-trans partial demethylation , increased accumulation of acetylated histones , and markedly *restored* the expression of [RARbeta2] in RARbeta2 negative cells . Positive_regulation RARB RAI2 7565739 324669 We now show that direct interaction between RAR and E1A is a requirement for [RAR beta] 2 *activation* . Positive_regulation RARB RAI2 8670275 369657 The retinoid , however , exhibited concentration dependent inhibitory effects on the basal level of transcriptional activity ( no other retinoid added ) of both the [RAR beta-] and RARgamma/RXRalpha heterodimers and of the transcriptional *activation* of the RARgamma/RXRalpha receptors . Positive_regulation RARB RARA 10629091 659424 Transcription of the retinoic receptor beta ( [RARbeta] ) gene is *activated* in a ligand dependent manner by the . Positive_regulation RARB RARA 10999756 734349 Lung was *induced* by 4.7-fold , [RARbeta] by 8.0-fold , and RARgamma by 8.1-fold . Positive_regulation RARB RARA 12921748 1130996 [RARbeta2] expression *requires* the expression of . Positive_regulation RARB RARA 16261163 1525710 In response to RA , [RARbeta2] transcription is epigenetically *regulated* by . Positive_regulation RARB RARA 16287870 1481163 Normally , *regulates* [RARbeta2] transcription by mediating dynamic changes of RARbeta2 chromatin in the presence and absence of RA . Positive_regulation RARB RARA 16289102 1484477 Moreover , the ATRA induced expression of [RARbeta] was also *mediated* by . Positive_regulation RARB RARA 7908827 241780 Induction of the HOXD4 promoter-enhancer in the presence of a selective RAR alpha antagonist indicated that the *dependent* [RAR beta] activation is nevertheless a necessary step in HOX gene activation . Positive_regulation RARB RARA 8689531 372590 In 12-day-old conceptuses exposed to all-trans-retinoic acid , did not increase significantly , but [RAR beta] *increased* 12-fold at 4 hr and RAR gamma 2-fold at 1 hr after the maternal treatments . Positive_regulation RARB RARA 9108446 424725 High-level expression of the [retinoic acid receptor beta] gene in normal cells of the uterine cervix is *regulated* by the and is abnormally down-regulated in cervical carcinoma cells . Positive_regulation RARB RARA 9116296 423565 These data suggest that is *necessary* for appropriate response of the [RAR beta] and RAR gamma genes to physiologic changes and deregulation of the RAR alpha in transgenic mice , which resulted in upregulation of RAR beta and RAR gamma , can be associated with lymphomagenesis . Positive_regulation RARB RARG 8314353 249393 [RAR beta] was not *detected* in any of the cell lines , while ( 3 kb ) was expressed in all of the ovarian cancer cells but at a very low level in the RA-resistant IGROV1 cells . Positive_regulation RARB RARG 8603404 352175 [RAR-beta/gamma] and anti-AP-1-selective retinoids , but not RAR-alpha-selective compounds , *induced* increased mRNA levels . Positive_regulation RARB RARG 8670275 369658 The retinoid , however , exhibited concentration dependent inhibitory effects on the basal level of transcriptional activity ( no other retinoid added ) of both the [RAR beta-] and RARgamma/RXRalpha heterodimers and of the retinoic acid induced transcriptional *activation* of the receptors . Positive_regulation RARB RARG 9774664 540023 In the presence of RA , the expression of is reduced and that of [RARbeta2] is *induced* . Positive_regulation RARB RARS 15189119 1256677 We then focus on a discussion of RARalpha and acute promyelocytic leukemia followed by a discussion of the *role* of , in particular [RARbeta] expression , in other cancer types . Positive_regulation RARB SLC1A1 19450544 2120304 We conclude that in C6 glioma cells the induction of by ATRA *requires* the synthesis of [RARbeta] , suggesting that the receptor is involved in the regulation of the transporter gene . Positive_regulation RARB TERT 14586406 1159579 Our previous work showed that acquisition of immortality at the dysplasia stage of oral cancer progression was consistently associated with four changes : loss of [retinoic acid receptor (RAR)-beta] and p16INK4A expression , p53 mutations and *activation* of . Positive_regulation RARB TGFB1 7556459 327696 alone *had* no effect on [RAR-beta] mRNA expression . Positive_regulation RARB THRA 1850112 155500 or a similar protein , however , does *enhance* binding of [retinoic acid receptor-beta] to a hormone response element . Positive_regulation RARB THRAP3 1850112 155508 or a similar protein , however , does *enhance* binding of [retinoic acid receptor-beta] to a hormone response element . Positive_regulation RARG RARB 8603404 352177 and anti-AP-1-selective retinoids , but not RAR-alpha-selective compounds , *induced* increased [RAR-gamma] mRNA levels . Positive_regulation RARG RARB 9774664 540024 In the presence of RA , the expression of [RARgamma1] is reduced and that of is *induced* . Positive_regulation RARRES1 CTCF 22615834 2603906 Epigenetic repression of [RARRES1] is *mediated* by methylation of a proximal promoter and a loss of binding . Positive_regulation RARRES3 TGM2 15846304 1398990 These findings suggest that [TIG3] forms a complex with transglutaminase resulting in transglutaminase activation and that activity is *required* for the TIG3 dependent biological response . Positive_regulation RARS FAS 11260077 796100 ligation *increased* apoptosis and decreased colony growth equally in [RARS] and controls , but caused significantly more caspase activation in RARS ( P < 0.01 ) . Positive_regulation RASA1 ANGPT1 21885850 2496451 *requires* IQ domain [GTPase activating protein] 1 to activate Rac1 and promote endothelial barrier defense . Positive_regulation RASA1 MAP2K6 12429740 1036985 expression of constitutively active Raf-1 kinase or was *sufficient* to induce p190 [Rho-GAP] translocation . Positive_regulation RASA3 INS 10869341 722326 Thus , the Ins ( 1,3,4,5 ) P ( 4 ) -binding PH domain from GAP1(IP4BP) defines a novel class of group I PH domains that constitutively targets the protein to the plasma membrane and may allow [GAP1(IP4BP)] to be *regulated* in vivo by ( 1,3,4,5 ) P ( 4 ) rather than PtdIns ( 3,4,5 ) P ( 3 ) . Positive_regulation RASD1 MAGEA11 22891251 2682645 In contrast , was not *required* for progesterone up-regulation of [RASD1] in endometrial cells expressing the PR-A/B heterodimer . Positive_regulation RASD1 POLR1E 19733236 2147126 We determined that amino acids 54-175 of are *essential* for interaction with [Dexras1] and that specific point mutations located within this region enhance PRAF1-Dexras1 interactions . Positive_regulation RASGRP1 DGKI 15894621 1411640 *regulates* [Ras guanyl releasing protein] 3 and inhibits Rap1 signaling . Positive_regulation RASGRP1 EPHB2 23589333 2789588 We previously described how [RasGRP] alone *induces* analog activation while SOS and RasGRP cooperate to establish bimodal ERK activation . Positive_regulation RASGRP2 EPHB2 23589333 2789592 We previously described how [RasGRP] alone *induces* analog activation while SOS and RasGRP cooperate to establish bimodal ERK activation . Positive_regulation RASGRP3 DGKI 15894621 1411657 Because Rap1 can antagonize the function of Ras , our data are consistent with a model in which *regulates* [RasGRP3] with a predominant effect on Rap1 activity . Positive_regulation RASGRP3 EPHB2 23589333 2789564 We previously described how [RasGRP] alone *induces* analog activation while SOS and RasGRP cooperate to establish bimodal ERK activation . Positive_regulation RASGRP4 EPHB2 23589333 2789568 We previously described how [RasGRP] alone *induces* analog activation while SOS and RasGRP cooperate to establish bimodal ERK activation . Positive_regulation RASSF1 FAS 19062280 2001794 NDR kinase is activated by [RASSF1A/MST1] in *response* to receptor stimulation and promotes apoptosis . Positive_regulation RASSF4 FOXO1 24334454 2894930 We have now found that this bypass occurs in part through *mediated* upregulation of [RASSF4] , a Ras-association domain family (RASSF) member . Positive_regulation RB1 CCND1 10376532 623427 The phosphorylation of [pRb] is *regulated* positively by and negatively by CDK inhibitors , such as p16 ( CDKN2/MTS-1/INK4A ) . Positive_regulation RB1 CCND1 10843991 721992 protein expression is regulated by mitogens , and its assembly with the cyclin dependent kinases *induces* phosphorylation of the retinoblastoma protein [pRb] , a critical step in G ( 1 ) to S phase cell cycle progression contributing to the proliferative responses . Positive_regulation RB1 CCND1 17897300 1802861 However , [pRb] phosphorylation and cell cycle progression *mediated* by expressed via t ( 11 ; 14 ) was less dependent on exogenous stimuli . Positive_regulation RB1 CCND1 18156803 1838397 The suppression of and cyclin E by curcumin may *inhibit* CDK mediated phosphorylation of [pRb] protein . Positive_regulation RB1 CCND1 19638577 2118600 loss *inhibited* [pRb] S780 phosphorylation by cyclin D1-cdk4/6 and released p21 from cyclin D1-cdk4/6-p21 protein complexes to form cyclin E2-cdk2-p21 complexes , which repressed phosphorylation of pRb S612 by cyclin E2-cdk2 and ultimately E2F-DP transcriptional activity . Positive_regulation RB1 CCND1 21937957 2497473 We conclude that 2CLP impaired hepatocyte proliferation following 2CLP in part via impaired *induced* phosphorylation of [pRb] , maintaining the association between pRb and E2F and inhibited E2F transcriptional activity . Positive_regulation RB1 CCND1 7739541 305736 These data provide evidence for an upstream control function of , and a downstream *role* for [pRB] , in the order of events regulating transition through late G1 phase of the mammalian cell division cycle . Positive_regulation RB1 CCND1 7791752 313313 We show here that while premature expression of either cyclin alone advances the G1/S-phase transition to the same extent , premature expression of *leads* to immediate appearance of hyperphosphorylated [pRb] , while premature expression of cyclin E does not . Positive_regulation RB1 CCND1 8552398 347211 These observations suggest that the suppression of in pRb-minus tumour cell lines *requires* both loss of [pRb] and at least one additional genetic event . Positive_regulation RB1 CCND1 8704183 373372 Our data from primary lymphoma tissue suggests that overexpression of , whereas tumorigenic , does not *lead* to [pRB] loss or hyperphosporylation . Positive_regulation RB1 CCND1 8805225 382212 We have identified a 20-residue synthetic peptide -- corresponding to amino acids 84-103 of p16 -- that interacts with cdk4 and cdk6 , and inhibits the in vitro phosphorylation of [pRb] *mediated* by . Positive_regulation RB1 CCND1 8867812 389146 In mitogen stimulated cells induction in early G1 is *followed* by induction of cyclin E , activation of the cyclin dependent kinase Cdk2 , and hyperphosphorylation of the retinoblastoma gene product ( [pRB] ) in mid-to-late G1 phase . Positive_regulation RB1 CCND1 9771970 539364 Thus , at least one adhesion mediated signalling event , distinct from MAP kinase activation is required for maximal *induction* and hyperphosphorylation of [pRb] . Positive_regulation RB1 EPHB2 15138593 1246397 A specific inhibitor , PD98059 , *blocked* paclitaxel induced ERK activation and [pRB] phosphorylation at Ser795 in Ma-10 cells . Positive_regulation RB1 FAS 15585647 1345671 may therefore be a new therapeutic *target* for [osteosarcoma] . Positive_regulation RB1 IFI27 14597415 1160657 In the presence of TSH , transforming growth factor beta ( TGFbeta ) did not affect the assembly of cyclin D3-CDK4 , but it strongly *inhibited* the [pRb-kinase] activity associated with both cyclin D3 and p27 , not only by preventing the nuclear import of cyclin D3-CDK4 and its binding to , but also by inhibiting CDK4 phosphorylation within residual p27 bound cyclin D3-CDK4 complexes . Positive_regulation RB1 SMN2 22415578 2681286 The most common in the osteosarcoma group was breast cancer ( n = 11 ) , and the most common SMN in the Ewing sarcoma group was radiotherapy *induced* [osteosarcoma] ( n = 6 ) . Positive_regulation RB1 TNF 10651228 578091 *induced* hyperphosphorylated [pRB] in SV40 transformed keratinocytes . Positive_regulation RB1 TNF 24190483 2885870 , interleukin-1ß and LPS *enhanced* [osteosarcoma] U2OS MMP-9 secretion but had no effect on MMP-2 secretion . Positive_regulation RBBP4 CAPN8 17986223 1850874 Interestingly , [SAP] did not *induce* caspase and activation , suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways . Positive_regulation RBBP4 EPHB2 15261456 1274510 Furthermore , inhibition of *blocked* [HDAC] inhibitor induced LL-37 expression in colonic and gastric cells . Positive_regulation RBBP4 IL1B 10958685 726156 We have investigated the ability of dexamethasone to regulate *induced* gene expression , histone acetyltransferase ( HAT ) and [histone deacetylase (HDAC)] activity . Positive_regulation RBBP4 IL1B 16847181 1588147 The messenger RNA expressions of [LARC] ( liver and activation regulated chemokine ) , GMCSF ( granulocyte-macrophage colony stimulating factor ) , epiregulin , ICAM1 ( intercellular adhesion molecule 1 ) , and TGFA ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation RBBP4 MAP2K6 15261456 1274516 Furthermore , inhibition of *blocked* [HDAC] inhibitor induced LL-37 expression in colonic and gastric cells . Positive_regulation RBBP4 TNF 10788429 688669 Acute phorbol 12-myristate 13-acetate pretreatment also inhibited *stimulated* [SAP] kinase activity , while chronic pretreatment reversed the effects of UTP . Positive_regulation RBBP4 ZFP57 20808772 2314104 Levels of both and PcG proteins inversely correlated with those of reactive oxygen species ( ROS ) in senescing MEFs , but the treatment of Zfp277 ( -/- ) MEFs with an antioxidant *restored* the binding of [PRC2] but not PRC1 to the Ink4a/Arf locus . Positive_regulation RBBP5 TNF 16386180 1494196 Cytokines are the direct mediators for multiple organ failure (MOF) , and [MOF] is *triggered* by and a cascade of cytokine release , with a prolonged high-expression of IL-6 . Positive_regulation RBBP7 CAPN8 17986223 1850901 Interestingly , [SAP] did not *induce* caspase and activation , suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways . Positive_regulation RBBP7 EPHB2 15261456 1274518 Furthermore , inhibition of *blocked* [HDAC] inhibitor induced LL-37 expression in colonic and gastric cells . Positive_regulation RBBP7 IL1B 10958685 726157 We have investigated the ability of dexamethasone to regulate *induced* gene expression , histone acetyltransferase ( HAT ) and [histone deacetylase (HDAC)] activity . Positive_regulation RBBP7 MAP2K6 15261456 1274524 Furthermore , inhibition of *blocked* [HDAC] inhibitor induced LL-37 expression in colonic and gastric cells . Positive_regulation RBBP7 TNF 10788429 688670 Acute phorbol 12-myristate 13-acetate pretreatment also inhibited *stimulated* [SAP] kinase activity , while chronic pretreatment reversed the effects of UTP . Positive_regulation RBBP7 ZFP57 20808772 2314122 Levels of both and PcG proteins inversely correlated with those of reactive oxygen species ( ROS ) in senescing MEFs , but the treatment of Zfp277 ( -/- ) MEFs with an antioxidant *restored* the binding of [PRC2] but not PRC1 to the Ink4a/Arf locus . Positive_regulation RBL2 CAPN8 11511102 848874 In contrast , the cleavage of paxillin and [p130cas] in apoptotic L929 cells was *blocked* by inhibitors , which also reduced the death rate by 23 to 44 % . Positive_regulation RBL2 EDN2 10402223 628921 *stimulates* tyrosine phosphorylation of p125FAK and [p130Cas] in rat cerebral cortex . Positive_regulation RBL2 EDN2 9083073 420955 Vasopressin , , bradykinin , lysophosphatidic acid , sphingosylphosphorylcholine , and phorbol 12,13-dibutyrate also *stimulated* [p130] ( cas ) tyrosine phosphorylation . Positive_regulation RBL2 EPHB2 23109808 2695312 EGF *activated* FAK ( Y397 ) and [p130cas] ( Y410 ) phosphorylation , while Fn activated general phosphorylation . Positive_regulation RBL2 ITGB2 8631823 357173 Phosphorylation of [p130cas] was *dependent* on binding of to its ligand , ICAM-1 , as demonstrated by the use of anti-ICAM-1 antibodies . Positive_regulation RBM45 TNF 21617122 2436341 Peptides of sense-PR3 and complementary-PR3 also bound to *induced* surface expression of [DRB1*1501] on peripheral neutrophils . Positive_regulation RBM5 MAP2K6 22022968 2499136 Mycobacterium tuberculosis [H37Rv-] and H37Ra induced Bcl-2 production was *reduced* by specific inhibitors of ( PD98059 ) and p38 ( SB203580 ) , but increased by nuclear factor ?B ( NF-?B ) inhibitor ( BAY 11-7082 ) . Positive_regulation RBM5 TNF 22022968 2499119 Mycobacterium tuberculosis [H37Rv] *induced* higher Bcl-2 and lower levels , whereas H37Ra the reverse . Positive_regulation RBP1 TGM2 6149218 42211 Our studies suggest that retinoic acid and serum [retinol binding protein] can directly regulate macrophage gene expression and specifically *induce* the synthesis of . Positive_regulation RBP2 TGM2 6149218 42212 Our studies suggest that retinoic acid and serum [retinol binding protein] can directly regulate macrophage gene expression and specifically *induce* the synthesis of . Positive_regulation RBP3 TGM2 6149218 42213 Our studies suggest that retinoic acid and serum [retinol binding protein] can directly regulate macrophage gene expression and specifically *induce* the synthesis of . Positive_regulation RBP4 CLU 22715704 2616407 Urinary RBP , NAG and were more sensitive than SCr and BUN as indicators for early renal injury in the order of RBP > NAG > CLU , and urinary [RBP] , NAG would *increase* earlier than beta2-MG . Positive_regulation RBP4 TGM2 6149218 42214 Our studies suggest that retinoic acid and serum [retinol binding protein] can directly regulate macrophage gene expression and specifically *induce* the synthesis of . Positive_regulation RBP5 TGM2 6149218 42209 Our studies suggest that retinoic acid and serum [retinol binding protein] can directly regulate macrophage gene expression and specifically *induce* the synthesis of . Positive_regulation RBP7 TGM2 6149218 42210 Our studies suggest that retinoic acid and serum [retinol binding protein] can directly regulate macrophage gene expression and specifically *induce* the synthesis of . Positive_regulation RCAN1 ATF6 18319259 1904291 The ability of to *induce* [RCAN1] in vivo was replicated in cultured cardiac myocytes , where adenoviral ( AdV ) -mediated overexpression of activated ATF6 induced the RCAN1 promoter , up-regulated RCAN1 mRNA , inhibited calcineurin phosphatase activity , and exerted a striking growth modulating effect that was inhibited by RCAN1 targeted small interfering RNA . Positive_regulation RCAN1 BTRC 24218457 2879485 We further demonstrated that *induced* [Rcan1] expression is dependent on the transcription factor early growth response 1 (Egr1) . Positive_regulation RCAN1 CREB1 18485898 1916807 *activates* proteasomal degradation of [DSCR1/RCAN1] . Positive_regulation RCAN1 CREB1 21890628 2496520 Furthermore , we found that the increased *activation* of signaling by [RCAN1] depended on the ability of RCAN1 to inhibit calcineurin activity . Positive_regulation RCAN1 CREB3 18485898 1916808 *activates* proteasomal degradation of [DSCR1/RCAN1] . Positive_regulation RCAN1 CREB3 21890628 2496521 Furthermore , we found that the increased *activation* of signaling by [RCAN1] depended on the ability of RCAN1 to inhibit calcineurin activity . Positive_regulation RCAN1 CREB5 18485898 1916806 *activates* proteasomal degradation of [DSCR1/RCAN1] . Positive_regulation RCAN1 CREB5 21890628 2496519 Furthermore , we found that the increased *activation* of signaling by [RCAN1] depended on the ability of RCAN1 to inhibit calcineurin activity . Positive_regulation RCAN1 CUL1 24218457 2879486 We further demonstrated that *induced* [Rcan1] expression is dependent on the transcription factor early growth response 1 (Egr1) . Positive_regulation RCAN1 DYRK1A 21965663 2507434 *mediated* phosphorylation of [RCAN1] at Ser ( 112 ) primes the protein for the GSK3ß mediated phosphorylation of Ser ( 108 ) . Positive_regulation RCAN1 DYRK1A 24021800 2862404 *mediated* phosphorylation of [RCAN1] promotes the formation of insoluble RCAN1 aggregates . Positive_regulation RCAN1 DYRK1A 24021800 2862405 We show that RCAN1 self-associates and forms multimers , and that this process is promoted by the *mediated* phosphorylation of [RCAN1] at the Thr ( 192 ) residue . Positive_regulation RCAN1 EGF 17941051 1858693 Nerve growth factor and are unable to *induce* the expression of the Crem/Icer , Nur77 , Nor1 , Rgs2 , Dusp1 ( Mkp1 ) , and [Dscr1] genes in PC12 cells , validating their identification as IPD-IEGs . Positive_regulation RCAN1 EGR1 24218457 2879487 We further demonstrated that SCF induced [Rcan1] expression is *dependent* on the transcription factor . Positive_regulation RCAN1 GATA2 15448146 1334959 VEGF- and thrombin mediated induction of [DSCR-1] *involves* the cooperative binding of NF-ATc and to neighboring consensus motifs in the upstream promoter . Positive_regulation RCAN1 GATA3 15448146 1334960 VEGF- and thrombin mediated induction of [DSCR-1] *involves* the cooperative binding of NF-ATc and to neighboring consensus motifs in the upstream promoter . Positive_regulation RCAN1 GPR1 19331211 2052775 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR101 19331211 2052731 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR107 19331211 2052736 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR108 19331211 2052735 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR110 19331211 2052741 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR111 19331211 2052742 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR112 19331211 2052743 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR113 19331211 2052740 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR114 19331211 2052744 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR115 19331211 2052745 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR116 19331211 2052746 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR119 19331211 2052747 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR12 19331211 2052776 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR123 19331211 2052728 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR124 19331211 2052737 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR125 19331211 2052729 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR126 19331211 2052730 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR128 19331211 2052748 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR132 19331211 2052734 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR133 19331211 2052749 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR135 19331211 2052750 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR137 19331211 2052768 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR139 19331211 2052751 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR141 19331211 2052752 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR142 19331211 2052753 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR143 19331211 2052754 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR144 19331211 2052739 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR146 19331211 2052756 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR148 19331211 2052760 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR149 19331211 2052762 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR15 19331211 2052777 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR150 19331211 2052763 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR151 19331211 2052761 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR152 19331211 2052759 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR153 19331211 2052758 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR155 19331211 2052757 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR156 19331211 2052755 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR157 19331211 2052764 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR158 19331211 2052765 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR160 19331211 2052766 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR161 19331211 2052767 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR162 19331211 2052732 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR17 19331211 2052778 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR171 19331211 2052770 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR173 19331211 2052738 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR174 19331211 2052771 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR176 19331211 2052774 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR179 19331211 2052773 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR18 19331211 2052779 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR180 19331211 2052769 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR182 19331211 2052726 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR183 19331211 2052772 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR19 19331211 2052780 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR20 19331211 2052781 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR21 19331211 2052782 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR22 19331211 2052783 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR25 19331211 2052784 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR26 19331211 2052785 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR27 19331211 2052786 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR3 19331211 2052787 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR31 19331211 2052788 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR32 19331211 2052789 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR33 19331211 2052790 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR34 19331211 2052791 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR35 19331211 2052792 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR36 19331211 2052793 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR37 19331211 2052794 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR39 19331211 2052795 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR4 19331211 2052796 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR42 19331211 2052797 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR45 19331211 2052798 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR50 19331211 2052799 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR52 19331211 2052800 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR55 19331211 2052801 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR56 19331211 2052802 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR6 19331211 2052803 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR61 19331211 2052723 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR62 19331211 2052724 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR63 19331211 2052725 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR64 19331211 2052804 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR65 19331211 2052805 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR68 19331211 2052806 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR75 19331211 2052808 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR78 19331211 2052809 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR79 19331211 2052810 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR82 19331211 2052811 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR83 19331211 2052807 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR84 19331211 2052812 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR85 19331211 2052813 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR87 19331211 2052814 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR88 19331211 2052815 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR97 19331211 2052727 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GPR98 19331211 2052733 It has been revealed that metastin/a ( AXOR12 ) signaling *enhances* the expression of [Down syndrome critical region 1 (DSCR1)] , known to be duplicated in Down syndrome , and suppresses tumor metastasis in in vitro study . Positive_regulation RCAN1 GSK3B 16649988 1557384 This suggests that [RCAN1-1S] might *induce* production of in vivo . Positive_regulation RCAN1 GSK3B 16649988 1557386 While RCAN1s can regulate calcineurin and GSK-3beta , it has also been shown that calcineurin and can *regulate* [RCAN1s] . Positive_regulation RCAN1 KDR 20625401 2291756 Our data suggests that RCAN1 .4 expression is induced by activation in a Ca ( 2+ ) and PKC-delta dependent manner and that [RCAN1] .4 *acts* to regulate calcineurin activity and gene expression facilitating endothelial cell migration and tubular morphogenesis . Positive_regulation RCAN1 MAP3K7 19136967 2032110 These results describe a signalling relationship between two central regulatory pathways in which selectively *induces* calcineurin-NFAT signalling through direct phosphorylation of [RCAN1] , while calcineurin activation diminishes TAK1 signalling by dephosphorylation of TAK1 and TAB1 . Positive_regulation RCAN1 NFATC1 14738882 1202876 [DSCR1] gene expression is *dependent* on during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice . Positive_regulation RCAN1 NFATC1 14738882 1202877 Furthermore , expression of the endogenous DSCR1 ( e4 ) isoform is decreased in the outflow tract of NFATc1 ( -/- ) hearts , and the [DSCR1] ( e4 ) intragenic element is trans *activated* by in cell culture . Positive_regulation RCAN1 NFATC1 15448146 1334961 VEGF- and thrombin mediated induction of [DSCR-1] *involves* the cooperative binding of and GATA-2/3 to neighboring consensus motifs in the upstream promoter . Positive_regulation RCAN1 NFATC1 17693409 1805906 is *sufficient* to induce the expression of [Dscr1] in cells that normally have undetectable or minimal NFATc1 or DSCR1 . Positive_regulation RCAN1 NFATC2 15975916 1440989 Exogenous potently *augmented* the [DSCR1] .4 promoter transcriptional activity , and the involvement of endogenous NFAT signaling pathway in DSCR1 .4 transcription was confirmed by the suppression of depolarization-inducible promoter activity with the NFAT inhibitor peptide VIVIT . Positive_regulation RCAN1 NFATC2 23028325 2679590 Kaposi 's sarcoma herpesvirus K15 protein contributes to virus induced angiogenesis by recruiting PLC?1 and activating *dependent* [RCAN1] expression . Positive_regulation RCAN1 NFATC2 23028325 2679593 We found that K15 directly recruits PLC?1 , and thereby activates *dependent* [RCAN1] expression which results in the formation of angiogenic tubes . Positive_regulation RCAN1 NFATC4 23178899 2723771 Over-expression of *up-regulated* collagen III , MRTF-A ( a transcriptional regulator of SMA ) and the NFAT-target [regulator of calcineurin 1] .4 ( RCAN1.4 ) . Positive_regulation RCAN1 NFKB1 17641395 1771446 [DSCR1] is *induced* by NFAT or and limits Ca ( ++ ) signaling in a negative feed-back loop . Positive_regulation RCAN1 NGF 17941051 1858694 and epidermal growth factor are unable to *induce* the expression of the Crem/Icer , Nur77 , Nor1 , Rgs2 , Dusp1 ( Mkp1 ) , and [Dscr1] genes in PC12 cells , validating their identification as IPD-IEGs . Positive_regulation RCAN1 PPP3CA 11110780 757418 In the present study , we show that expression of [MCIP1] is *regulated* by activity in hearts of mice with cardiac hypertrophy , as well as in cultured skeletal myotubes . Positive_regulation RCAN1 PPP3CA 12554096 1051461 Transcription of the mammalian [MCIP1] gene is *induced* by , suggesting that it functions as an endogenous feedback regulator of calcineurin signal transduction . Positive_regulation RCAN1 PPP3CA 14976250 1213024 In the heart , the [MCIP1] gene is *activated* by and has been proposed to fulfill a negative feedback loop that restrains potentially pathological calcineurin signaling , which would otherwise lead to abnormal cardiac growth . Positive_regulation RCAN1 PPP3CA 15263820 1296101 Moreover , VEGF stimulated induction of [DSCR1] was *blocked* by anti-VEGF receptor-2 monoclonal antibody ( mAb ) , or the specific inhibitors cyclosporin A and FK506 . Positive_regulation RCAN1 PPP3CA 15975916 1440986 This calcium dependent transcription of [DSCR1] .4 was *inhibited* by the inhibitors cyclosporin A and FK506 . Positive_regulation RCAN1 PPP3CA 15975916 1440990 These findings suggest that *dependent* induction of [DSCR1] .4 product may represent an important auto-regulatory mechanism for the homeostatic control of NFAT signaling in neural cells . Positive_regulation RCAN1 PPP3CA 16649988 1557387 While RCAN1s can regulate calcineurin and GSK-3beta , it has also been shown that and GSK-3beta can *regulate* [RCAN1s] . Positive_regulation RCAN1 PPP3CA 18293408 1891587 Finally , we report that *dependent* expression of Cox-2 and [Rcan 1-4] is induced by physiological calcium mobilizing agents , such as thrombin , agonists of purinergic and glutamate receptors , and L-type voltage gated calcium channels . Positive_regulation RCAN1 PPP3CA 19136967 2032111 These results describe a signalling relationship between two central regulatory pathways in which TAK1-TAB1-TAB2 selectively *induces* signalling through direct phosphorylation of [RCAN1] , while calcineurin activation diminishes TAK1 signalling by dephosphorylation of TAK1 and TAB1 . Positive_regulation RCAN1 PPP3CA 23028325 2679594 We found that K15 directly recruits PLC?1 , and thereby activates *dependent* [RCAN1] expression which results in the formation of angiogenic tubes . Positive_regulation RCAN1 PPP3CB 12554096 1051462 Transcription of the mammalian [MCIP1] gene is *induced* by , suggesting that it functions as an endogenous feedback regulator of calcineurin signal transduction . Positive_regulation RCAN1 PPP3CB 14976250 1213025 In the heart , the [MCIP1] gene is *activated* by and has been proposed to fulfill a negative feedback loop that restrains potentially pathological calcineurin signaling , which would otherwise lead to abnormal cardiac growth . Positive_regulation RCAN1 PPP3CB 15975916 1440987 This calcium dependent transcription of [DSCR1] .4 was *inhibited* by the inhibitors cyclosporin A and FK506 . Positive_regulation RCAN1 PPP3CB 15975916 1440991 These findings suggest that dependent *induction* of [DSCR1] .4 product may represent an important auto-regulatory mechanism for the homeostatic control of NFAT signaling in neural cells . Positive_regulation RCAN1 PPP3CB 18293408 1891588 Finally , we report that *dependent* expression of Cox-2 and [Rcan 1-4] is induced by physiological calcium mobilizing agents , such as thrombin , agonists of purinergic and glutamate receptors , and L-type voltage gated calcium channels . Positive_regulation RCAN1 PPP3CB 19136967 2032112 These results describe a signalling relationship between two central regulatory pathways in which TAK1-TAB1-TAB2 selectively *induces* signalling through direct phosphorylation of [RCAN1] , while calcineurin activation diminishes TAK1 signalling by dephosphorylation of TAK1 and TAB1 . Positive_regulation RCAN1 PPP3CB 23028325 2679595 We found that K15 directly recruits PLC?1 , and thereby activates *dependent* [RCAN1] expression which results in the formation of angiogenic tubes . Positive_regulation RCAN1 PPP3CC 12554096 1051463 Transcription of the mammalian [MCIP1] gene is *induced* by , suggesting that it functions as an endogenous feedback regulator of calcineurin signal transduction . Positive_regulation RCAN1 PPP3CC 14976250 1213026 In the heart , the [MCIP1] gene is *activated* by and has been proposed to fulfill a negative feedback loop that restrains potentially pathological calcineurin signaling , which would otherwise lead to abnormal cardiac growth . Positive_regulation RCAN1 PPP3CC 15975916 1440988 This calcium dependent transcription of [DSCR1] .4 was *inhibited* by the inhibitors cyclosporin A and FK506 . Positive_regulation RCAN1 PPP3CC 15975916 1440992 These findings suggest that *dependent* induction of [DSCR1] .4 product may represent an important auto-regulatory mechanism for the homeostatic control of NFAT signaling in neural cells . Positive_regulation RCAN1 PPP3CC 18293408 1891589 Finally , we report that *dependent* expression of Cox-2 and [Rcan 1-4] is induced by physiological calcium mobilizing agents , such as thrombin , agonists of purinergic and glutamate receptors , and L-type voltage gated calcium channels . Positive_regulation RCAN1 PPP3CC 19136967 2032113 These results describe a signalling relationship between two central regulatory pathways in which TAK1-TAB1-TAB2 selectively *induces* signalling through direct phosphorylation of [RCAN1] , while calcineurin activation diminishes TAK1 signalling by dephosphorylation of TAK1 and TAB1 . Positive_regulation RCAN1 PPP3CC 23028325 2679596 We found that K15 directly recruits PLC?1 , and thereby activates *dependent* [RCAN1] expression which results in the formation of angiogenic tubes . Positive_regulation RCAN1 PPP3R1 11110780 757419 In the present study , we show that expression of [MCIP1] is *regulated* by activity in hearts of mice with cardiac hypertrophy , as well as in cultured skeletal myotubes . Positive_regulation RCAN1 PPP3R1 15263820 1296102 Moreover , VEGF stimulated induction of [DSCR1] was *blocked* by anti-VEGF receptor-2 monoclonal antibody ( mAb ) , or the specific inhibitors cyclosporin A and FK506 . Positive_regulation RCAN1 PPP3R1 16649988 1557388 While RCAN1s can regulate calcineurin and GSK-3beta , it has also been shown that and GSK-3beta can *regulate* [RCAN1s] . Positive_regulation RCAN1 RELA 17641395 1771447 [DSCR1] is *induced* by NFAT or and limits Ca ( ++ ) signaling in a negative feed-back loop . Positive_regulation RCAN1 SKP1 24218457 2879484 We further demonstrated that *induced* [Rcan1] expression is dependent on the transcription factor early growth response 1 (Egr1) . Positive_regulation RCAN1 STAT2 22426484 2577615 The transcription factor *enhances* proteasomal degradation of [RCAN1] through the ubiquitin E3 ligase FBW7 . Positive_regulation RCAN1 STAT2 22426484 2577616 Decreases in RCAN1 were blocked by a proteasome inhibitor , indicating that *regulates* [RCAN1] degradation via the ubiquitin-proteasome system . Positive_regulation RCAN1 TAB1 19136967 2032109 These results describe a signalling relationship between two central regulatory pathways in which selectively *induces* calcineurin-NFAT signalling through direct phosphorylation of [RCAN1] , while calcineurin activation diminishes TAK1 signalling by dephosphorylation of TAK1 and TAB1 . Positive_regulation RCAN1 TAB2 19136967 2032108 These results describe a signalling relationship between two central regulatory pathways in which selectively *induces* calcineurin-NFAT signalling through direct phosphorylation of [RCAN1] , while calcineurin activation diminishes TAK1 signalling by dephosphorylation of TAK1 and TAB1 . Positive_regulation RCAN1 TEF 18840614 1993960 was *required* for [DSCR1-1L] expression through binding to the M-CAT site in its promoter and could be an attractive target for anti-angiogenesis therapy . Positive_regulation RCAN1 TNF 15358155 1293358 We show in this study that [DSCR1] is greatly induced in endothelial cells in *response* to VEGF , , and A23187 treatment , and that this up-regulation is inhibited by inhibitors of the calcineurin-NFAT ( nuclear factor of activated T cells ) signaling pathway as well as by PKC inhibition and a Ca ( 2+ ) chelator . Positive_regulation RCAN1 TNF 16627481 1583042 We recently reported that thrombin and vascular endothelial growth factor , but not , *results* in dramatic up-regulation of [Down syndrome critical region (DSCR)-1] gene in endothelial cells , a negative feedback regulator of calcineurin-NFAT signaling . Positive_regulation RCAN1 VEGFA 15263820 1296100 Moreover , *stimulated* induction of [DSCR1] was blocked by anti-VEGF receptor-2 monoclonal antibody ( mAb ) , or the specific calcineurin inhibitors cyclosporin A and FK506 . Positive_regulation RCAN1 VEGFA 15358155 1293359 We show in this study that [DSCR1] is greatly induced in endothelial cells in *response* to , TNF-alpha , and A23187 treatment , and that this up-regulation is inhibited by inhibitors of the calcineurin-NFAT ( nuclear factor of activated T cells ) signaling pathway as well as by PKC inhibition and a Ca ( 2+ ) chelator . Positive_regulation RCAN1 VEGFA 15448146 1334958 and thrombin mediated *induction* of [DSCR-1] involves the cooperative binding of NF-ATc and GATA-2/3 to neighboring consensus motifs in the upstream promoter . Positive_regulation RCAN1 VEGFA 16627481 1583043 We recently reported that thrombin and , but not tumor necrosis factor-alpha , *results* in dramatic up-regulation of [Down syndrome critical region (DSCR)-1] gene in endothelial cells , a negative feedback regulator of calcineurin-NFAT signaling . Positive_regulation RCAN1 VEGFA 18840614 1993959 We reported previously that another DSCR1 isoform , DSCR1-1L , was also up-regulated by ( 165 ) in cultured endothelial cells and in several in vivo models of pathological angiogenesis and that different from DSCR1-4 , [DSCR1-1L] overexpression alone *induced* cultured endothelial cell proliferation and promoted angiogenesis in Matrigel assays . Positive_regulation RCAN1 VEGFA 19620774 2118213 We previously reported that *induces* [DSCR-1s] expression in endothelial cells , which in turn negatively feeds back to attenuate endothelial cell activation . Positive_regulation RCAN1 VEGFA 20625401 2291752 *stimulates* [RCAN1] .4 expression in endothelial cells via a pathway requiring Ca2+/calcineurin and protein kinase C-delta . Positive_regulation RCAN1 VEGFA 20625401 2291754 We show that VEGF is able to induce RCAN1 .4 expression during cellular proliferation and differentiation , and that *mediated* expression of [RCAN1] .4 was inhibited by the use of inhibitors to protein kinase C ( PKC ) and calcineurin . Positive_regulation RCAN1 VEGFA 20625401 2291755 Further analysis revealed that siRNA silencing of PKC-delta expression partially inhibited *stimulated* [RCAN1] .4 expression . Positive_regulation RCAN1 VEGFA 21042787 2339211 [RCAN1] and 2 are strongly *induced* by ( VEGF ) , inhibit cell proliferation and down-regulate many pro-inflammatory and pro-angiogenic genes . Positive_regulation RCAN1 VEGFA 23028325 2679591 During physiological angiogenesis , expression of [RCAN1] in endothelial cells is *regulated* by ( vascular endothelial growth factor ) through a pathway involving the activation of PLC?1 , Calcineurin and NFAT1 . Positive_regulation RCAN2 RCAN1 17610901 1786692 Here we show that a panel of pro-angiogenic factors , including VEGF , basic fibroblast growth factor (bFGF) , angiopoietin 1 , hepatocyte growth factor , as well as triiodo-l-thyronine ( T ( 3 ) ) , does not *induce* [DSCR1-L1] up-regulation in endothelial cells , while VEGF potently up-regulates . Positive_regulation RCC2 STK39 18083840 1837257 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation RCN1 TNF 18561328 1940788 Novel surface expression of [reticulocalbin 1] on bone endothelial cells and human prostate cancer cells is *regulated* by . Positive_regulation RECK ANGPT1 20407016 2262404 Here , we show that an angiogenic factor *induces* [RECK] expression in human umbilical vein endothelial cells ( HUVEC ) , and RECK depletion in these cells results in defective vascular tube formation and cellular senescence . Positive_regulation RECQL4 CCND1 21173237 2373664 [RTs] are exquisitely *dependent* on for genesis and survival . Positive_regulation RECQL4 NES 22824301 2676784 Collectively , our study demonstrates that *mediated* [RecQL4] export to the cytoplasm is essential for the maintenance of mitochondrial genome stability . Positive_regulation REG1A CAPN8 19181619 2033188 Our study revealed that inhibitors ( calpeptin and MG132 ) transform a facilitating synapse into a depressing one , and *reduce* its [PTP] by 80.6 % . Positive_regulation REG1A TNF 16574984 1568544 SHP-1 and SHP-2 protein levels were unaltered by or GH , and the GH-induced increase in SHP-1 [PTP] activity was not further *increased* by TNF . Positive_regulation REG1A TNF 21483233 2562074 The underlying molecular mechanism by which *regulates* hepatic [protein-tyrosine phosphatase (PTP)-1B] expression is not well understood . Positive_regulation REG1A TNF 22203215 2585897 The present data suggest that *induces* aberrant [REG1a] expression and that REG1a plays an important role in aberrant cell proliferation and RANKL expression of synovial fibroblasts , ultimately resulting in pannus formation . Positive_regulation REL ANKRD1 8627798 356052 Furthermore , while the ankyrin repeat domain of p40 is sufficient for association with c-Rel , both the and the PEST domain are *required* for association with [v-Rel] . Positive_regulation REL CD14 10996025 733678 In the present study , we investigated the *role* of and complement receptor type 3 (CR3) in mediating NO production and [NF-kappaB/Rel] activation induced by angelan and LPS . Positive_regulation REL HRH1 23075496 2740417 Our results suggest that [c-Rel] controls *mediated* proinflammatory cytokine production in DCs . Positive_regulation REL IL1B 11912207 944619 In both cultured rat cerebellar granule cells and mouse hippocampal slices , we examined [NF-kappaB/Rel] *activation* induced by two opposing modulators of cell viability : 1 ) , which promotes neuron survival and 2 ) glutamate , which can elicit toxicity . Positive_regulation REL IL1B 8940164 399092 Utilization of antisense technology showed that p65 but not p50 or [c-Rel] mediated *stimulated* PGE2 formation . Positive_regulation REL JAG1 10329626 613627 Both [c-Rel] and RelA *induced* gene expression , whereas a mutant defective for transactivation did not . Positive_regulation REL NES 11970947 953837 A functional is *required* for both efficient cytoplasmic retention and post-induction control of [c-Rel] by IkappaBepsilon , consistent with the notion that IkappaBepsilon mediated nuclear export contributes to control over the nucleocytoplasmic distribution of NF-kappaB/Rel proteins . Positive_regulation REL S100B 15312903 1285300 potently *activates* [p65/c-Rel] transcriptional complexes in hippocampal neurons : Clinical implications for the role of S100B in excitotoxic brain injury . Positive_regulation REL S100B 15312903 1285303 Our data suggest that secreted during the glial response to brain injury potently *activates* [p65/c-Rel] in a RAGE dependent manner and may exert neuroprotective and neuroregenerative effects in psychiatric disorders . Positive_regulation REL TLR7 11135578 794958 Lipopolysaccharide (LPS) induction of the gene encoding interleukin 12 p40 requires remodeling of a promoter encompassing nucleosome and the *mediated* activation of a [c-Rel] containing complex . Positive_regulation REL TLR7 19005481 2041461 IL-10 was found to downregulate MyD88 , IRAK1 ( IL-1 receptor associated kinase ) and tumor necrosis factor receptor associated factor 6 , essential adaptor molecules for TLR signaling , and to decrease *induced* nuclear expression of the nuclear factor-kappaB transcription factors [c-Rel] and Rel-B as well as interferon regulatory factor (IRF)-3 and IRF-8 . Positive_regulation REL TNF 11350953 834342 Our results indicate that overexpression of cRel or *activation* of endogenous [Rel/NF-kappaB] factors by in HeLa cells up-regulates DcR1 without changing the expression of DcR2 , DR4 , and DR5 and makes cells resistant against TRAIL induced apoptosis . Positive_regulation REL TNF 12065710 954670 Silymarin also inhibited *induced* [NF-kappaB/Rel] activation , whereas okadaic acid induced NF-kappaB/Rel activation was not affected . Positive_regulation REL TNF 12935892 1132873 Moreover , silymarin suppressed the *induced* DNA binding of [NF-kappaB/Rel] in HUVECs . Positive_regulation REL TNF 17675290 1794081 By electrophoretic mobility shift assay analyses , and lipopolysaccharide *induce* strong p65/p50 and [p65/c-Rel] heterodimer binding to both NF-kappaB and TF-kappaB probes . Positive_regulation REL TNF 8152812 253062 *Activation* of multiple NF-kappa [B/Rel] DNA binding complexes by . Positive_regulation REL TNF 9185524 436713 The constitutive and *induced* [NF-kappaB/Rel] complexes were identical and were composed mainly of p50 and c-Rel proteins . Positive_regulation REL TNF 9185524 436716 These results indicate that the aberrant , constitutive GM-CSF gene activation in JMML is maintained by mediated *activation* of [NF-kappaB/Rel] proteins . Positive_regulation REL TNF 9435232 482485 Therefore , UVB induced *activation* of [Rel] proteins via receptor 1 , independent of ligand activation , is a key component in the UV response in keratinocytes . Positive_regulation RELA ADRB2 19167076 2043520 *regulate* Toll-like receptor 4-induced late-phase [NF-kappaB] activation . Positive_regulation RELA ALOX5 10022882 590409 Reactive oxygen intermediate dependent [NF-kappaB] activation by interleukin-1beta *requires* <5-lipoxygenase> or NADPH oxidase activity . Positive_regulation RELA ALOX5 11390371 842561 We show that in addition to inhibitors of secretory and cytosolic PLA(2)s , <5-lipoxygenase> inhibitors *attenuate* TNF-alpha- and IL-1beta stimulated [NF-kappaB] activation . Positive_regulation RELA ALOX5 15161935 1295146 However , <5-lipoxygenase> inhibition had no effect on alpha7-nAChR mRNA expression , but significantly *inhibited* cell proliferation and activation of [NF-kappaB] and cyclooxygenase-2 , whereas NF-kappaB-specific inhibitor caffeic acid phenethyl ester reduced both cell proliferation and cyclooxygenase expression induced by NNK without affecting alpha7-nAChR mRNA level and 5-lipoxygenase expression . Positive_regulation RELA ALOX5 17925309 1844100 In addition , the inhibition of <5-LO> by AA861 markedly *reduced* AcQ induced [nuclear factor kappa B (NF-kappa B)] activation . Positive_regulation RELA ALOX5 9120300 423853 In transiently transfected HUVECs , [NF-kappa B-dependent] gene expression was *inhibited* by <5-lipoxygenase> inhibitors . Positive_regulation RELA ANGPT1 17599743 1774567 In addition , *activated* [NF-kappaB] via Akt to promote cell growth , but also inhibited cell apoptosis via ERK and Akt . Positive_regulation RELA ARSA 11238116 790486 The inhibitory effect of on IL-4 transcription was not *mediated* by decreased nuclear expression of the known salicylate target [nuclear factor (NF)-kappaB] and was accompanied by reduced binding of an inducible factor to an IL-4 promoter region upstream of , but not overlapping , the NF of activated T cells- and NF-kappaB binding P1 element . Positive_regulation RELA ARSA 18174252 1875686 The effect of NO-ASA on NF-kappaB binding to DNA was significantly correlated with its effect on cell growth ( P < 0.05 ) indicating that the growth inhibitory effect of may be *mediated* by its effect on [NF-kappaB] . Positive_regulation RELA CAPN8 12670502 1076059 These observations indicate that in monocyte/macrophage cells calcium signaling is involved in [NF-kappa B] *activation* through activation of and thus calpain inhibitors may be effective in inhibiting the activation of latently infected HIV . Positive_regulation RELA CAPN8 14686903 1179522 Our data indicate that the Ca2+ dependent protease is *involved* in the [NF-kappaB] activation in neurons in response to N-methyl-d-aspartate receptor occupancy by glutamate . Positive_regulation RELA CAPN8 14686903 1179578 [NF-kappaB] *activation* by may mediate the long-term effects of glutamate on neuron survival or memory formation . Positive_regulation RELA CAPN8 16885359 1596343 In support , a inhibitor *impaired* [NF-kappaB] activation in MeWo ( cis1 ) cells . Positive_regulation RELA CAPN8 9186501 436852 This suggests that *contributes* to silica induced I kappa B alpha degradation and [NF-kappa B] activation but not to LPS induced I kappa B alpha degradation and NF-kappa B activation . Positive_regulation RELA CCND1 10409765 630556 NF-kappaB regulation of occurs at the transcriptional level and is *mediated* by direct binding of [NF-kappaB] to multiple sites in the cyclin D1 promoter . Positive_regulation RELA CCND1 10464245 640347 Induction of by Rac1 *required* both an [NF-kappaB] and an ATF-2 binding site . Positive_regulation RELA CCND1 15893541 1407603 To determine whether the NNK induced [NFkappaB] activation and *induction* were also observed in vivo , A/J mice were treated with NNK ( 9.1 mg ) for 20 weeks and the results showed a significant induction of cyclin D1 and NFkappaB translocation determined by immunoblotting analyses . Positive_regulation RELA CCND1 16230390 1470080 The induction of by arsenite *required* [nuclear factor-kappaB (NF-kappaB)] activation , because the inhibition of IkappaB phosphorylation by overexpression of the dominant negative mutant , IKKbeta-KM , impaired arsenite induced cyclin D1 expression and G1-S transition . Positive_regulation RELA CCND1 16940298 1627461 Here we show that HBx up-regulates and that this process is *mediated* by the [NF-kappaB2] ( p52 ) /BCL-3 complex . Positive_regulation RELA CCND1 17008396 1674084 To further understand the mechanism of TNF stimulated growth of primary MEC , the requirement for [NFkappaB1/p50] , and the *role* of in TNF stimulated growth were examined . Positive_regulation RELA CCND1 17440100 1729489 P = 0.036 versus gemcitabine alone ) , Ki-67 proliferation index ( P = 0.030 versus control ) , [NF-kappaB] *activation* , and expression of NF-kappaB regulated gene products ( , c-myc , Bcl-2 , Bcl-xL , cellular inhibitor of apoptosis protein-1 , cyclooxygenase-2 , matrix metalloproteinase , and vascular endothelial growth factor ) compared with tumors from control mice treated with olive oil only . Positive_regulation RELA CD14 10996025 733680 In the present study , we investigated the *role* of and complement receptor type 3 (CR3) in mediating NO production and [NF-kappaB/Rel] activation induced by angelan and LPS . Positive_regulation RELA CD14 11343695 813954 The binding of lipopolysaccharide to its receptor *activates* protein kinase C and [nuclear factor-kappaB (NF-kappaB)] . Positive_regulation RELA CD14 11546774 882123 In conclusion , H. pylori induced [NF-kappaB] activation in epithelial cells is dependent on cag PAI and contact but does not *involve* and IRAK , whereas in macrophage/monocytic cells it is independent of cag PAI or contact but involves CD14 and TLR4 . Positive_regulation RELA CD14 11779220 900061 *dependent* activation of [NF-kappaB] by filarial parasitic sheath proteins . Positive_regulation RELA CD14 11779220 900068 Herein we provide evidence that FPS activation of [NF-kappaB] can be *augmented* by the cell surface expression of . Positive_regulation RELA CD14 12062631 953259 Recent evidence supports the suggestion that endotoxin induced signal transduction begins with *mediated* activation of Toll-receptor 4 and subsequent activation of [nuclear factor-kappa B (NF-kappa B)] binding activity . Positive_regulation RELA CD14 12379680 997305 These results indicate that the polysaccharide portion covalently bound to lipid A plays the principal role in Salmonella LPS induced *activation* of [NF-kappaB] through human . Positive_regulation RELA CD14 15731076 1377585 Our results show that and TLR4 are *necessary* for low-dose ( 300-microg/ml ) LPS induced microvascular leakage , [NF-kappaB] activation , neutrophil influx , cytokine and chemokine ( KC , macrophage inflammatory protein 2 , tumor necrosis factor alpha , interleukin-6 ) expression , and subsequent lung damage . Positive_regulation RELA CD14 16879219 1593846 Lipopolysaccharide induced decreased protein S expression in liver cells is mediated by MEK/ERK signaling and [NFkappaB] *activation* : involvement of membrane bound and toll-like receptor-4 . Positive_regulation RELA CD14 16879219 1593852 Antirat and antirat TLR-4 antibodies inhibited LPS induced NFkappaB activation , and a [NFkappaB] inhibitor *suppressed* LPS induced decreased PS expression in both cells . Positive_regulation RELA CD14 16879219 1593873 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by MEK/ERK signaling and [NFkappaB] activation and that membrane bound and TLR-4 are *involved* in this mechanism . Positive_regulation RELA CD14 17522215 1767215 [NF-kappaB] activation in HEK293-TLR2 cells ( HEK293 cells transfected with TLR2 ) by EBV was not *enhanced* by the presence of . Positive_regulation RELA CD14 18458151 1927017 Expression of markedly enhanced LTA binding to the plasma membrane and also *enhanced* [NF-kappaB] activation . Positive_regulation RELA CD14 19840871 2203180 Intriguingly , MD2 did play a significant role in activating [NF-kappaB] by PG in the *presence* of . Positive_regulation RELA CD14 20394816 2282077 The evidence suggests that these changes are a likely consequence of increased hippocampal expression of and TLR4 , and [NFkappaB] *activation* in SIGIRR ( -/- ) mice . Positive_regulation RELA CD14 9574560 502560 This study was undertaken to evaluate the *role* of and complement receptors type 3 (CR3) and 4 ( CR4 ) in mediating TNF release and [NF-kappaB] activation induced by LPS and cell wall preparations from group B streptococci type III ( GBS ) . Positive_regulation RELA CLU 17056579 1636650 We propose that in RA joints , high levels of extracellular and low expression of intracellular CLU may *enhance* [NF-kappaB] activation and survival of the synoviocytes . Positive_regulation RELA CLU 23270201 2709665 The genes that are down-regulated in stress are cell cycle *inhibitors* , apoptosis related genes , antiproliferative cytokines and , the [NF-kappaB] inhibitor . Positive_regulation RELA CTGF 16303051 1490775 *Activation* of [nuclear factor kappa B (NF-kappaB)] by ( CCN2 ) is involved in sustaining the survival of primary rat hepatic stellate cells . Positive_regulation RELA CTGF 16303051 1490778 *induced* IkappaBalpha phosphorylation and degradation as well as nuclear accumulation of [NF-kappaB] . Positive_regulation RELA CTGF 16408113 1513487 *enhanced* the mRNA expression and protein release of fractalkine , MCP-1 , and RANTES , the expression of phospho ( P ) -p42/44 mitogen activated protein kinase (MAPK) , P-phosphoinositide 3-kinase (PI3-K) , P-Akt , and activity of [nuclear factor-kappaB (NF-kappaB)] in mesangial cells . Positive_regulation RELA CTGF 16408113 1513535 P-PI3-K blockade downregulated the *stimulated* expression of P-PI3-K , P-Akt , and [NF-kappaB] but not P-p42/44 MAPK , and partially decreased the release of the above chemokines . Positive_regulation RELA CTGF 16408113 1513544 LXA ( 4 ) dose-dependently inhibited the *stimulated* mRNA expression and protein release of the above chemokines , and the expression of P-p42/44MAPK , P-PI3-K , P-Akt , and [NF-kappaB] . Positive_regulation RELA CTGF 16707502 1584473 Thus , mechanical stretch induced changes in actin dynamics mediate [NF-kappaB] activation and *induce* gene expression , which probably initiates the fibrotic reactions observed in mechanical overload associated pathologies . Positive_regulation RELA CTGF 18639630 1954658 *stimulated* binding of [NF-kappaB] to the IL-6 promoter , and siRNA targeting the NF-kappaB subunit RelA interfered with CTGF induced IL-6 expression , implicating the NF-kappaB pathway in the mediation of the CTGF effect . Positive_regulation RELA CTNNAL1 17952117 1889011 , a Rho signalling component , can *regulate* [NF-kappaB] through binding to IKK-beta , and confers resistance to apoptosis . Positive_regulation RELA CTNNAL1 17952117 1889019 Ectopic expression of *augmented* [NF-kappaB] activity , promoted cell migration and increased resistance to apoptosis , whereas knockdown experiments showed the opposite effects . Positive_regulation RELA EDN2 11692473 876496 The subsequent [NF-kappa B] activation probably *involves* participation of signaling and , perhaps , NF-AT3 activation . Positive_regulation RELA EDN2 15860794 1425773 MBP1 *induced* activation of neural [nuclear factor (NF)-kappaB] , from 10 min to 12 h , declining by 24 h , whereas induced a short lived activation of NF-kappaB . Positive_regulation RELA EPHB2 10878013 722415 We have shown that both the and p38 mitogen activated protein ( MAP ) kinases are necessary for cytokine gene transcription and that the p38 MAP kinase is *required* for [NF-kappaB-driven] transcription , so we hypothesized that the MEK -- > ERK pathway regulated NF-kappaB-driven transcription as well . Positive_regulation RELA EPHB2 11278990 811642 Specific effects on [NF-kappa B-inducing] kinase activity and on the coordinate *activation* of and p38 MAPK . Positive_regulation RELA EPHB2 11371570 834867 This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and and *activation* of cAMP-responsive element binding protein ( CREB ) , [NF-kappaB] , and E2F ) , as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs . Positive_regulation RELA EPHB2 11741913 904993 Analyzing the effects of several inhibitors or mutant receptors revealed that this [NF-kappa B] activation is *mediated* neither by nor by the phosphatidylinositol 3-kinase pathway but by STAT5 . Positive_regulation RELA EPHB2 11742864 887449 These data suggest that activity is *required* for persistent [NF-kappaB] activation by IL-1beta that is necessary for iNOS gene expression . Positive_regulation RELA EPHB2 11773061 916288 Moreover , the NF-kappa B promoter activity decreased with overexpression of dominant negative ERK expression constructs , and EMSA analyses further support the hypothesis that acts upstream of NF-kappa B and *regulates* the [NF-kappa B] DNA binding activity . Positive_regulation RELA EPHB2 12143039 969604 An adv expressing dominant negative ( dn ) TRAF2 inhibited only JNK and not or [NF-kappa B] *activation* . Positive_regulation RELA EPHB2 12426209 1014370 Treatment of VSMCs with PDGF or EGF alone potently induced phosphorylation and DNA synthesis but did not *induce* [NF-kappaB] activation or iNOS expression . Positive_regulation RELA EPHB2 12426209 1014383 Inhibition of phosphorylation with selective inhibitors ( PD98059 or U0126 ) *attenuated* interleukin-1beta induced persistent [NF-kappaB] activation and iNOS expression in either the absence or presence of the growth factors . Positive_regulation RELA EPHB2 12677169 1076926 We demonstrate , for the first time , that glycated albumin activates RAW cell ERK and promotes *dependent* increases in TGF-beta(1) production , oxidative stress , and [NF-kappa B] activation . Positive_regulation RELA EPHB2 12694399 1080741 These results indicate that D2R induced [NF-kappaB] *activation* through may be involved in activation of the NCAM promoter , and additionally that other protein kinases such as CaM KII and p38 MAPK also regulate NCAM expression . Positive_regulation RELA EPHB2 12934647 1132826 Sodium salicylate inhibits expression of COX-2 through suppression of and subsequent [NF-kappaB] *activation* in rat ventricular cardiomyocytes . Positive_regulation RELA EPHB2 14581482 1186910 In cultured rat vascular smooth muscle cells , sustained activation of is *required* for interleukin-1beta to persistently activate [NF-kappaB] . Positive_regulation RELA EPHB2 14715266 1197298 These data suggest that ERK and dependent [NF-kappaB] *activation* is required for oxidative stress induced inhibition of osteoblastic differentiation in rabbit BMSC and calvarial osteoblasts . Positive_regulation RELA EPHB2 15106733 1240532 Salicylate regulates COX-2 expression through and subsequent [NF-kappaB] *activation* in osteoblasts . Positive_regulation RELA EPHB2 15147892 1248136 HHE increased the activity of p38 MAPK and extracellular signal regulated kinase ( ERK ) , but not c-jun NH ( 2 ) -terminal kinase , indicating that p38 MAPK and are closely *involved* in HHE induced [NF-kappaB] transactivation . Positive_regulation RELA EPHB2 15210577 1268079 Regulation of metalloproteinases and [NF-kappaB] *activation* in rabbit synovial fibroblasts via E prostaglandins and : contrasting effects of nabumetone and 6MNA . Positive_regulation RELA EPHB2 15485634 1320648 CD40- and BAFF mediated survival is significantly increased in Act1-deficent B cells , with stronger IkappaB phosphorylation , processing of [NF-kappaB2] ( p100/p52 ) , and *activation* of JNK , , and p38 pathways , indicating that Act1 negatively regulates CD40- and BAFF mediated signaling events . Positive_regulation RELA EPHB2 15589482 1356237 In addition , luteolin inhibited TNF-alpha induced phosphorylation of p38 MAPK and , IkappaB degradation , and [NF-kappaB] *activation* . Positive_regulation RELA EPHB2 15843535 1398460 To identify a molecular basis for this receptor cross-talk , we examined activation and [NF-kappaB] *induction* . Positive_regulation RELA EPHB2 15870903 1405573 In addition , GA inhibited TNF-alpha induced phosphorylation of p38 MAPK and , I kappa B alpha degradation , and [NF-kappa B] *activation* . Positive_regulation RELA EPHB2 16326421 1488357 Together these results suggest that while gamma-IR and Ras both contribute to the upregulation of CD23 expression via NF-kappaB Raf or is not *involved* in gamma-IR induced [NF-kappaB] activation . Positive_regulation RELA EPHB2 16436136 1516434 The induction of RANTES by SCF or TNF-alpha was mediated by ERK and [NF-kappaB] , respectively , and SCF induced MIP-1beta release was *mediated* by . Positive_regulation RELA EPHB2 16563718 1631150 Furthermore , inhibition of activity by PD98059 and PI3K/Akt activity by LY294002 or wortmannin significantly *reduced* the LA-induced activation of [nuclear factor kappa B (NF-kappaB)] . Positive_regulation RELA EPHB2 16705144 1638289 Selective suppression of or p38 MAP kinase significantly *attenuated* activation of [NF-kappaB] in mesangial cells triggered by coculture with isolated glomeruli . Positive_regulation RELA EPHB2 16870149 1593098 However , this activation of [NF-kappaB] *requires* the PI3K and PKC signaling pathways , but not or JNK . Positive_regulation RELA EPHB2 16966488 1627827 Phosphorylation of *led* to an activation of [NFkappaB] , as indicated by increased p50 subunit expression in nuclear extracts , and increased mRNA levels of the antioxidant enzyme manganese-superoxide dismutase ( MnSOD ) . Positive_regulation RELA EPHB2 16972253 1627867 The increase in oxidative stress induced [NF-kappaB] activity was *mediated* by activation of . Positive_regulation RELA EPHB2 16996785 1746975 [NF-kappaB] expression induced by safrole in fibroblasts may be *mediated* by activation and COX-2 signal transduction pathway . Positive_regulation RELA EPHB2 17478933 1738643 The inhibition of can *suppress* the DNA binding activity of [NF-kappaB] and the cell proliferation mediated by HCV NS3 protein in a dose dependent manner . Positive_regulation RELA EPHB2 17499198 1739930 Molecular mechanisms that govern attenuation of the levels of mRNAs and proteins of these cytokines and iNOS revealed that the PC extract inhibited LPS stimulated phosphorylation of and *activation* of [NF-kappaB] . Positive_regulation RELA EPHB2 17602748 1842187 Immunofluorescence analysis detected nuclear translocation of the [NF-kappaB] p50 subunit and this was *blocked* by inhibitor , indicating that GITRL stimulation induced ERK1/2 phosphorylation and subsequent activation of NF-kappaB . Positive_regulation RELA EPHB2 17891781 1888857 Furthermore , inhibitors ( U0126 and PD98059 ) *suppressed* LPA stimulated activation of [NF-kappaB] and p65 phosphorylation whereas wortmannin showed no effect on NF-kappaB activation . Positive_regulation RELA EPHB2 18080123 1903349 The inhibitors of NF-kappaB , JNK and p38 , but not , decreased IL-1beta enhanced MMP-1 , MMP-3 and NO production , respectively , and 100 nM celecoxib *down-regulated* the phosphorylation of [NF-kappaB] and JNK but has no effect on either p38 or ERK . Positive_regulation RELA EPHB2 18335517 1925145 These data indicate that near-physiological concentrations of Mn potentiate cytokine induced expression of NOS2 and production of NO in astrocytes via activation of sGC , which promotes *dependent* enhancement of [NF-kappaB] signaling . Positive_regulation RELA EPHB2 18434625 1920918 Collectively , our data demonstrate that SP enhances selective inflammatory chemokine production by murine macrophages via MAPK *mediated* [NF-kappaB] activation . Positive_regulation RELA EPHB2 18442745 1900609 SNP induced the phosphorylation of p38 MAPK and , degradation and phosphorylation of IkappaB , and *activation* of [NF-kappaB] . Positive_regulation RELA EPHB2 19093035 2003827 Pre-treatment with the MAP kinase kinase (MEK)-1/2 inhibitor U0126 showed that cytokine triggered [NF-kappaB] nuclear translocation and transcriptional activity are *mediated* by activation of . Positive_regulation RELA EPHB2 19214689 2034141 Mechanical stress on the LHB and RI in the shoulder may *induce* and JNK to express [NF-kappaB] by CD29 to develop capsule contracture , producing MMP-3 , IL-6 , and VEGF . Positive_regulation RELA EPHB2 19429670 2106930 The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with Ang II was inhibited by either inhibitor , p38MAPK inhibitor or [NF-kappaB] *inhibitor* . Positive_regulation RELA EPHB2 19472212 2102240 JAKs inhibitors suppressed IFN-gamma plus TNF-alpha induced production of CXCL10 in parallel with activation of STAT1 and NF-kappaB , while inhibitor *suppressed* production of CXCL10 as well as activation of [NF-kappaB] , but not that of STAT1 . Positive_regulation RELA EPHB2 19619321 2118170 Unlike Paclitaxel , ARRY-520 did not induce [NF-kappaB] activation , did not enhance cytokine secretion , nor *induce* phosphorylation in Type I EOC cells . Positive_regulation RELA EPHB2 20054486 2177439 HF6-FC exerts its inhibitory effects by suppression of p38 and [NF-kappaB] but *activation* of . Positive_regulation RELA EPHB2 20121399 2206958 In THP-1 cells , p38 , , and JNK inhibition *increased* [NF-kappaB] and Sp1 binding to the IL-12p40 promoter , while inhibiting AP-1 binding . Positive_regulation RELA EPHB2 20537708 2279376 In conclusion , all these findings demonstrate a key *role* of and TLR4 in association with [NF-kappaB] in IL-10 modulation induced by T. cruzi and suggest that this regulatory effect involves parasite-DC interactions not described yet . Positive_regulation RELA EPHB2 20546116 2308513 Blockage of moesin function interrupts the LPS response through an inhibition of MyD88 , IRAK and TRAF6 , negatively affecting subsequent activation of the MAP kinases ( p38 and ) , [NF-kappaB] *activation* and translocation to the nucleus . Positive_regulation RELA EPHB2 9689078 522805 We have previously shown that mitogen activated protein kinase kinase 1 ( MEKK1 ) can *induce* both this site-specific phosphorylation of IkappaB alpha at Ser-32 and Ser-36 in vivo and the activity of a high molecular weight [IkappaB kinase complex] in vitro . Positive_regulation RELA F2R 10372815 622100 *Activation* of [NFkappaB] via either or PAR-2 does not predict mitogenesis . Positive_regulation RELA F2R 12215488 986047 Cotransfection of RGS3T , a regulator of G-protein signaling that inhibits Galpha ( q ) , or alpha-transducin ( Galpha ( t ) ) , a scavenger of the Gbetagamma , markedly decreased [NF-kappaB] activity *induced* by activation . Positive_regulation RELA F2R 12215488 986054 These results support a model in which ligation of *induces* [NF-kappaB] activation and ICAM-1 transcription by the engagement of parallel Galphaq/PKC-delta and Gbetagamma/PI3-kinase pathways that converge at Akt . Positive_regulation RELA F2R 16052512 1460019 mediated [NFkappaB] *activation* promotes survival of prostate cancer cells through a Bcl-xL dependent mechanism . Positive_regulation RELA F2R 16052512 1460034 Inhibition of p38 and ERK1/2 by SB-203589 and PD-098059 , respectively , did not abrogate NFkappaB activity , suggesting an independent *induction* of [NFkappaB] by stimulation . Positive_regulation RELA F2R 16467309 1548222 Activation of or PAR-2 *promoted* nuclear translocation and phosphorylation of [p65-NF-kappaB] , and thrombin induced but not PAR-2 induced p65-NF-kappaB phosphorylation was reduced by inhibition of MEK or p38MAPK . Positive_regulation RELA F2R 19351910 2088759 Here we show that activation *induces* binding of both [p65/RelA] and NFATc1 to the NF-kappaB binding site localized in intron-1 of the ICAM-1 gene to initiate transcription in endothelial cells . Positive_regulation RELA F2R 19931359 2198028 Then we investigated whether the binding of APC to is *required* to control [NF-kappaB] activation . Positive_regulation RELA FAS 10022897 590540 Activation dependent transcriptional regulation of the human promoter *requires* [NF-kappaB] p50-p65 recruitment . Positive_regulation RELA FAS 10823821 714858 In HeLa cells , induction of apoptosis and [nuclear factor kappaB (NF-kappaB)] activation *initiated* by TRAIL/Apo2L or the agonistic Apo1/Fas-specific monoclonal antibody require the presence of cycloheximide ( CHX ) . Positive_regulation RELA FAS 10823821 714862 Inhibition of caspases prevented *induced* apoptosis , but not [NF-kappaB] activation , indicating that both pathways bifurcate upstream of the receptor-proximal caspase-8 . Positive_regulation RELA FAS 11464292 839435 Inhibition of protein kinase C by Gö6983 sensitized these cells to apoptotic challenges and strongly diminished *activation* of [NF-kappaB] by and TRAIL . Positive_regulation RELA FAS 11689460 876270 CD40 activation induced , *dependent* apoptosis and [NF-kappaB/AP-1] signaling in human intrahepatic biliary epithelial cells . Positive_regulation RELA FAS 12244143 990503 Fas resistance of leukemic eosinophils is due to *activation* of [NF-kappa B] by ligation . Positive_regulation RELA FAS 12244143 990509 Although activation of NF-kappaB by ligation of Fas ( CD95/Apo-1 ) , a member of the TNFR family , has been observed in a few studies , mediated [NF-kappaB] *activation* has not previously been shown to protect cells from apoptosis . Positive_regulation RELA FAS 12244143 990511 We examined the induced [NF-kappaB] *activation* and its antiapoptotic effects in a leukemic eosinophil cell line , AML14.3D10 , an AML14 subline resistant to Fas mediated apoptosis . Positive_regulation RELA FAS 12883671 1116459 stimulation *activates* [NF-kappaB] in SK-Hep1 hepatocellular carcinoma cells . Positive_regulation RELA FAS 12883671 1116463 However , the *role* of in induction of [NF-kappaB] activation in HCC cells is not well understood . Positive_regulation RELA FAS 12883671 1116469 stimulation *induced* [NF-kappaB] activation in a dose dependent manner in SK-Hep1 and HepG2 cell lines , but not in HLE cells . Positive_regulation RELA FAS 14625298 1200948 Caffeic acid phenethyl ester induces apoptosis by inhibition of [NFkappaB] and *activation* of in human breast cancer MCF-7 cells . Positive_regulation RELA FAS 15252018 1295924 We conclude that induce insulin resistance and *activates* [NFkappaB] in L6 cells . Positive_regulation RELA FAS 15289496 1278453 [NFkappaB] *activation* by is mediated through FADD , caspase-8 , and RIP and is inhibited by FLIP . Positive_regulation RELA FAS 15289496 1278455 Remarkably , the enzymatic activity of the latter was dispensable for *induced* [NFkappaB] signaling pointing to a scaffolding related function of caspase-8 in nonapoptotic Fas signaling . Positive_regulation RELA FAS 15467462 1347261 In fact overexpression of apoptosis inhibitors such as Bcl-2 or c-FLIPL in these cells results in decreased *activation* of [NF-kappaB] through . Positive_regulation RELA FAS 15514680 1328473 Induction of apoptosis and *activation* of [NF-kappaB] by require different signalling thresholds . Positive_regulation RELA FAS 16465219 478752 *activates* [NF-kappaB] and induces apoptosis in T-cell lines by signaling pathways distinct from those induced by TNF-alpha . Positive_regulation RELA FAS 16465219 478757 Surprisingly , induced signaling also *triggered* the activation of [NF-kappaB] in T cells , yet the kinetics of NF-kappaB induction by Fas was markedly delayed . Positive_regulation RELA FAS 16646028 1557256 stimulation *activated* [NF-kappaB] and AP-1 , and this response required caspase activity , since Z-VAD-FMK inhibitor precluded it . Positive_regulation RELA FAS 16855770 1646101 [NF-kappa B] is *activated* by increased in CORT induced Leydig cell apoptosis . Positive_regulation RELA FAS 17118453 1667834 Besides the apoptosis signaling pathway , ligation also *induces* the activation of [NF-kappaB] . Positive_regulation RELA FAS 17395209 1766129 TNFR1 ligation *induces* [NFkappaB] activation and the upregulation of chemokines MCP-1 and IL-8 , as well as adhesion molecules ICAM-1 and VCAM-1 , while and DR5 triggering activate the extracellular signal regulated kinases-1 and -2 ( Erk 1/2 , p42/44 MAPK ) inducing the release of matrix metalloproteinase 9 (MMP9) by BBB derived ECs . Positive_regulation RELA FAS 18348981 1905875 In conclusion , genetic inactivation of c-Met in mouse hepatocytes caused defects in redox regulation , which may account for the increased sensitivity to induced apoptosis and adaptive *up-regulation* of [NF-kappaB] survival signaling . Positive_regulation RELA FAS 18448526 1921252 Therefore , our results are in agreement with a model where LMP1 dependent [NF-kappaB] activation *induces* overexpression and autoactivation that could overwhelm the antiapoptotic effect of NF-kappaB , revealing an ambivalent function of LMP1 in cell survival and programmed cell death . Positive_regulation RELA FAS 20212524 2223107 We established an integrated kinetic mathematical model for *mediated* apoptotic and [NF-kappaB] signaling . Positive_regulation RELA FAS 20379197 2300420 In mutant PIK3CA expressing cells , tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) and *stimulated* [nuclear factor kappaB (NFkappaB)] activation , invasion , and transition to an amoeboid-like morphology . Positive_regulation RELA FAS 8597871 342617 With regard to their cytoplasmic homology region , we investigated whether like the TNF-R *activates* [nuclear factor kappa B (NF-kappa B)] , using human SV80 fibroblasts transfected with the cDNA encoding human Fas . Positive_regulation RELA FAS 8621545 360062 The ( APO-1/Fas ) receptor *activates* [NF-kappaB] independently of its cytotoxic function . Positive_regulation RELA FAS 8621545 360064 In an effort to understand CD95 mediated signaling , we assessed possible changes in the DNA binding activity of [NF-kappaB] as a *result* of engagement in various tumor cells . Positive_regulation RELA FAS 8621545 360066 By performing electrophoresis mobility shift assays , we show that can *stimulate* the DNA binding activity of [NF-kappaB] in a variety of cells , irrespective of their sensitivity or resistance to CD95 mediated cytotoxicity . Positive_regulation RELA FAS 9020361 413102 MAP3K related kinase involved in [NF-kappaB] *induction* by TNF , and IL-1 . Positive_regulation RELA FAS 9500443 490764 We demonstrate that ligation of ( Fas/APO1 ) , a potent apoptotic stimulus in lymphocytes , *results* in repression of [NF-kappaB] activity in Jurkat T cells by inducing the proteolytic cleavage of NF-kappaB p65 ( Rel A ) and p50 . Positive_regulation RELA FAS 9990295 597308 Cell death does correlate with alterations in NF-kappa B activity : the NSAIDs , butyrate and H2O2 enhance c-Rel complex formation by TNF-alpha and provide an overall enhancement of [NF-kappa B] *activation* by . Positive_regulation RELA FOXO1 17972158 1850074 The *activation* of [NF-kappaB] through Akt induced phosphorylation during aging and its modulation by calorie restriction . Positive_regulation RELA FOXO1 18226221 1884258 Phosphatidylinositol 3-kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of and non-canonical *activation* of [NFkappaB] transcription factors . Positive_regulation RELA FUT4 17410536 1736244 In an attempt to identify an effective therapeutic agent for pancreatic cancer , the authors studied the *role* of , a synthetic serine protease inhibitor , in the inhibition of [NF-kappaB] activation and the induction of apoptotic responses . Positive_regulation RELA GPR115 21159881 2385123 Phosphorylation and polyubiquitination of transforming growth factor beta activated kinase 1 are necessary for *activation* of [NF-kappaB] by the Kaposi 's sarcoma associated herpesvirus . Positive_regulation RELA GPR132 21159881 2385112 Phosphorylation and polyubiquitination of transforming growth factor beta activated kinase 1 are necessary for *activation* of [NF-kappaB] by the Kaposi 's sarcoma associated herpesvirus . Positive_regulation RELA GPR87 21159881 2385192 Phosphorylation and polyubiquitination of transforming growth factor beta activated kinase 1 are necessary for *activation* of [NF-kappaB] by the Kaposi 's sarcoma associated herpesvirus . Positive_regulation RELA HRH1 11641442 872157 In this study , we show that the , which is also an important player in allergic and inflammatory conditions , *activates* [NF-kappa B] in both a constitutive and agonist dependent manner . Positive_regulation RELA ID1 17012234 1641399 Aberrant activation of NF-kappaB transcription factors has been shown to contribute to the developmental defects , but it is not clear whether [NF-kappaB] activation is directly *due* to expression or is secondary to an abnormal thymic environment in Id1 transgenic mice . Positive_regulation RELA ID1 17012234 1641403 Here , by using a T cell line model , we demonstrate that expression stimulates basal levels of NF-kappaB activity and further *enhances* [NF-kappaB] activation upon T cell receptor ( TCR ) signaling achieved by anti-CD3 and anti-CD28 stimulation . Positive_regulation RELA IFI27 10353611 617649 In contrast to INK4 proteins , the cell cycle inhibitor *enhances* [NF-kappaB] transactivation activity . Positive_regulation RELA IFI27 17702989 1788825 Thus , is an important [NF-kappaB] *activator* in DCs and involved in IL-12 production , which may account for a T(h)1-prone phenotype of BWF1 mice . Positive_regulation RELA IL1B 10022882 590410 Reactive oxygen intermediate dependent [NF-kappaB] *activation* by requires 5-lipoxygenase or NADPH oxidase activity . Positive_regulation RELA IL1B 10022882 590416 Stimulation of lymphoid cells with *led* to ROI production and [NF-kappaB] activation , which could both be blocked by antioxidants or FLAP inhibitors , confirming that 5-LOX was the source of ROIs and was required for NF-kappaB activation in these cells . Positive_regulation RELA IL1B 10022882 590423 This pathway involves the Rac1 and Cdc42 GTPases , two enzymes which are not required for [NF-kappaB] *activation* by in epithelial cells . Positive_regulation RELA IL1B 10022882 590425 In conclusion , three different cell-specific pathways lead to [NF-kappaB] *activation* by : a pathway dependent on ROI production by 5-LOX in lymphoid cells , an ROI- and 5-LOX independent pathway in epithelial cells , and a pathway requiring ROI production by NADPH oxidase in monocytic cells . Positive_regulation RELA IL1B 10066820 593914 In contrast to the inability of LPS and IL-1beta alone to induce the expression of iNOS , both LPS and individually stimulated MAP kinase activity and *induced* DNA binding and transcriptional activity of [NF-kappaB] . Positive_regulation RELA IL1B 10066820 593916 Moreover , wortmannin had no effect on LPS- or mediated *activation* of MAP kinase and [NF-kappaB] , suggesting that wortmannin induced the expression of iNOS in LPS- or IL-1beta stimulated C6 glial cells without modulating the activation of MAP kinase and NF-kappaB . Positive_regulation RELA IL1B 10074208 594750 In contrast , infection with EZ did not block *activation* of the transcription factor [NF-kappaB] by . Positive_regulation RELA IL1B 10089132 600005 Because NF-kappaB is necessary for MCP-1 gene expression , the effect of p38 kinase inhibition on *induction* of [NF-kappaB] was measured . Positive_regulation RELA IL1B 10089132 600015 PD 098059 , a selective inhibitor of the ERK activating kinase MEK1 , had no effect on *induced* MCP-1 mRNA or protein levels , or on IL-1beta activation of [NF-kappaB] . Positive_regulation RELA IL1B 10218970 608581 Both and TNF-alpha *activated* [nuclear factor (NF)-kappaB] as demonstrated by electrophoretic mobility shift assay . Positive_regulation RELA IL1B 10232679 611405 Treatment with N ( G ) -nitro-L-arginine methyl ester ( L-NAME ) did not affect initial *activation* of [NF-kappaB] by , but unveiled an inhibitory effect of NO generation on NF-kappaB activity after 4 h . Positive_regulation RELA IL1B 10336492 615485 The activation of [NF-kappaB] and the subsequent cytokine induced neutrophil chemoattractant induction in *response* to were inhibited by proteasome inhibitors , MG132 and proteasome inhibitor I. Translocation of NF-kappaB into nuclei occurs by the phosphorylation , multi-ubiquitination , and degradation of IkappaBalpha , a regulatory protein of NF-kappaB . Positive_regulation RELA IL1B 10336492 615489 These results indicate that the transient translocation of [NF-kappaB] in *response* to may be partly dependent on transient proteasome activation . Positive_regulation RELA IL1B 10391885 626763 IkappaBalphaM was resistant to stimulus dependent degradation and suppressed [NF-kappaB] activation *induced* by TNF-alpha ( 10 ng/ml ) or ( 10 ng/ml ) . Positive_regulation RELA IL1B 10430178 633570 and TNF-alpha *stimulated* nuclear [NF-kappaB] levels by about fourfold and fivefold , respectively , in HASMCs . Positive_regulation RELA IL1B 10438477 634837 induced type II-sPLA ( 2 ) gene dose- and time-dependently and *increased* the binding of [NFkappaB] to a specific site of type II-sPLA ( 2 ) promoter . Positive_regulation RELA IL1B 10438953 635173 Using EMSA , we show that stimulation with TNF-alpha or *induces* [NF-kappa B] DNA binding activity in human airway smooth muscle cells . Positive_regulation RELA IL1B 10490923 645816 [NF-kappaB] activation in *response* to TNF-alpha , , phorbol ester , and H ( 2 ) O ( 2 ) was down-regulated by polaprezinc . Positive_regulation RELA IL1B 10515888 652052 Phenylarsine oxide blocks *induced* activation of the nuclear transcription factor [NF-kappaB] , inhibits proliferation , and induces apoptosis of acute myelogenous leukemia cells . Positive_regulation RELA IL1B 10515888 652054 Because PAO inhibits activation of the transcription factor NF-kappaB and because NF-kappaB modulates an array of signals controlling cellular survival , proliferation , and cytokine production , we also studied the effect of PAO on NF-kappaB activation in AML cells and found that PAO suppressed the induced *activation* of [NF-kappaB] . Positive_regulation RELA IL1B 10516205 652291 TNF-alpha enhanced MAP kinase activity was associated with an increase in *stimulated* [NF-kappaB] activity . Positive_regulation RELA IL1B 10544256 564103 Using electrophoretic mobility shift assays , we found that not only tumour necrosis factor-alpha (TNF-alpha) but also and parathyroid hormone (PTH) *caused* dose and time related increases in [nuclear factor kappaB (NF-kappaB)-DNA] binding in Saos-2 human osteoblastic ( hOB ) cells . Positive_regulation RELA IL1B 10564154 567138 In contrast to NAC , the metal chelators pyrrolidine dithiocarbamate and diethyldithiocarbamate attenuated induced [NF-kappaB] *activation* but had no effect on intracellular sulfhydryl content . Positive_regulation RELA IL1B 10594073 573025 An essential *role* of in mediating [NF-kappaB] activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia . Positive_regulation RELA IL1B 10605929 655652 We have studied whether ROIs played any role in [NF-kappaB] *induction* by in different cell types . Positive_regulation RELA IL1B 10605929 655654 Interestingly , transfection of epithelial cells with the 5-LOX and 5-LOX activating protein expression vectors restored ROI production and ROI dependent [NF-kappaB] activation in *response* to . Positive_regulation RELA IL1B 10605929 655658 Our data thus indicate that ROIs are cell type-specific second messengers for [NF-kappaB] *induction* by . Positive_regulation RELA IL1B 10617676 657183 *caused* the translocation of p65 [NF-kappaB] from cytosol to the nucleus as well as the degradation of IkappaB-alpha in cytosol . Positive_regulation RELA IL1B 10629862 576466 We also found in IL-1 beta induced CINC expression using cultured C6 glioma cells , the transient translocation of [NF-kappa B] in *response* to is partly dependent on transient proteasome activation . Positive_regulation RELA IL1B 10638662 660327 *induction* of [NF-kappaB] activation in human intestinal epithelial cells is independent of oxyradical signaling . Positive_regulation RELA IL1B 10638662 660332 Similarly , scavenging of free radicals and oxidants by pyrrolidine dithiocarbamate and dimethyl sulfoxide did not block *induced* IkappaBalpha degradation and [NF-kappaB] activation . Positive_regulation RELA IL1B 10638662 660334 Genistein , a nonspecific tyrosine kinase inhibitor , also had no effect on *mediated* effects on [NF-kappaB] . Positive_regulation RELA IL1B 10644648 661127 These data suggest that constitutive [NF-kappaB] p65 protein synthesis is *regulated* by , particularly during pregnancy . Positive_regulation RELA IL1B 10657679 664245 However , when the dependent *induction* of [NF-kappa B] was inhibited , the antiapoptotic effect of IL-1 beta was partially reversed , suggesting that NF-kappa B-mediated gene activation is part of the protective mechanism . Positive_regulation RELA IL1B 10677576 668277 We then investigated the effects of transfection of monocytes with these oligonucleotides on *stimulated* IL-8 production , IL-8 mRNA expression , and [NF-kappaB] binding activity . Positive_regulation RELA IL1B 10677576 668279 This single stranded oligonucleotide also inhibited *induced* translocation of [NF-kappaB] to the nucleus and reduced IL-8 mRNA expression . Positive_regulation RELA IL1B 10707928 673460 In PANC-1 cells , and TNF-alpha *induced* a rapid activation of [nuclear factor (NF)-kappaB] , and TGF-beta1 enhanced this activation slightly . Positive_regulation RELA IL1B 10766857 684569 Cellular differentiation causes a selective down-regulation of mediated [NF-kappaB] *activation* and IL-8 gene expression in intestinal epithelial cells . Positive_regulation RELA IL1B 10766857 684571 In this study , we analyzed and characterized the effect of the differentiation of intestinal epithelial cells on mediated [NF-kappaB] *activation* and IL-8 gene expression . Positive_regulation RELA IL1B 10766857 684574 We conclude that cellular differentiation of HT-29 cells selectively impairs the IL-1beta signaling pathway inhibiting both [NF-kappaB] and JNK activity in *response* to . Positive_regulation RELA IL1B 10816656 580268 Furthermore , we determined the effect of alpha-MSH on the induced *activation* of the [nuclear factor kappa B (NF kappa B)] -- a major transcription factor for chemokine genes . Positive_regulation RELA IL1B 10818069 693791 Addition of IL-1beta activated nuclear factor kappaB (NF-kappaB) in VSMCs , but sodium salicylate did not affect induced [NF-kappaB] *activation* . Positive_regulation RELA IL1B 10843878 700353 ( 1 ng/ml ) *induced* marked and persistent [NF-kappaB] activation in VSMC that was maximal at 1 h and persisted for 3 days . Positive_regulation RELA IL1B 10871193 706788 However , normal *mediated* translocation of [NF-kappaB] and induction of inducible nitric oxide synthase expression and nitric oxide production was severely impaired in the INS-1res cell lines , suggesting a mechanism for the IL-1beta resistance . Positive_regulation RELA IL1B 10881930 709234 and TNF-alpha *induced* a rapid activation of [nuclear factor (NF)-kappaB] in PANC-1 cells , and the increase in chemokine mRNA expression correlated with NF-kappaB activation . Positive_regulation RELA IL1B 10882729 730446 Neither receptor alone was able to mediate transcriptional activation of [NF-kappaB] in *response* to IL-1alpha , , or IL-18 . Positive_regulation RELA IL1B 10884313 709545 However , pretreatment with oATP downregulated *activation* of [NF-kappaB] and AP-1 by or TNFalpha . Positive_regulation RELA IL1B 11022128 738136 Using electrophoretic mobility shift assay ( EMSA ) , we show that *induced* [NFkappaB] activation in primary culture of mouse astrocytes is mediated by the interaction of this cytokine with the IL-1 type I receptor/IL-1 receptor accessory protein complex , as demonstrated by the ability of blocking monoclonal antibodies against these receptors to attenuate NFkappaB activation . Positive_regulation RELA IL1B 11022128 738153 Furthermore , anti-inflammatory cytokines such as IL-4 and IL-10 that block induced [NFkappaB] *activation* also attenuate IL-1beta induced Akt phosphorylation , despite the fact that IL-4 and IL-10 in isolation induced Akt phosphorylation . Positive_regulation RELA IL1B 11031204 740162 Electromobility gel shift and luciferase assays demonstrated that overexpression of IkappaBDeltaN inhibited [NF-kappaB] activation *induced* by TNF-alpha or . Positive_regulation RELA IL1B 11067942 747606 These results indicate that sustained [NF-kappaB] activation in asthmatic bronchi is driven by granulocytes and is *mediated* by and TNF-alpha . Positive_regulation RELA IL1B 11071643 748140 instead , *activated* [NF-kappaB] associated with 2 IL-6 responsive elements ( STAT3 binding site ) on the rat gamma fibrinogen promoter and blocked STAT3 binding to these regions . Positive_regulation RELA IL1B 11076795 749216 *induces* eotaxin gene transcription in A549 airway epithelial cells through [NF-kappaB] . Positive_regulation RELA IL1B 11087273 751211 HIV-gp120 enhanced p38 protein kinase activity was associated with an increase in *stimulated* [NF-kappaB] activity ( 184 +/- 12.7 vs. 92 +/- 10.7 optical units , IL-1beta + gp120 vs . IL-1beta , respectively ; n = 3 ) . Positive_regulation RELA IL1B 11090945 754714 We demonstrated that [NF-kappaB] *activation* by follows three distinct cell-specific pathways . Positive_regulation RELA IL1B 11104703 756490 However , pretreatment with the proteasome inhibitor MG132 under conditions that prevented the dependent *activation* of the nuclear factor [NF-kappaB] also blocked the inhibitory effect of IL-1beta on IL-6 activated STAT1 . Positive_regulation RELA IL1B 11104703 756502 Taken together , these findings indicate that , by using a proteasome dependent mechanism , concomitantly *induces* [NF-kappaB] activation and dephosphorylates IL-6 activated STAT1 ; Positive_regulation RELA IL1B 11114294 786557 Gel shift analysis showed that *activated* [NF-kappaB] in Calu-3 cells , and transfection experiments using p50 and RelA expressing vectors showed that exogenous transfected NF-kappaB subunits increased the concentration of CFTR mRNA . Positive_regulation RELA IL1B 11114294 786559 Gel shift analysis with antibody supershifting also showed that *caused* the binding of [NF-kappaB] to a kappaB-like response element at position -1103 to -1093 in the CFTR 5'-flanking region . Positive_regulation RELA IL1B 11115778 757920 Electrophoretic mobility shift assays ( EMSAs ) revealed that and TNF alpha *activate* the transcription factor [NF kappa B] in reaggregates of rat anterior pituitaries and in TtT/Gf cells cultured alone or cocultured with GH3 cells . Positive_regulation RELA IL1B 11191283 761384 The acid sphingomyelinase inhibitor SR33557 counteracts TNF-alpha mediated potentiation of *induced* [NF-kappaB] activation in the insulin producing cell line Rinm5F . Positive_regulation RELA IL1B 11191283 761396 TNF-alpha activated NF-kappaB in gel shift experiments without inducing iNOS -- as assessed by nitrite formation -- whereas *stimulated* both [NF-kappaB] activation and iNOS induction . Positive_regulation RELA IL1B 11274209 819041 This regulation of NF-kappaB activation by PKCdelta was specific only for TNFalpha signaling , since lipopolysaccharide- or induced [NF-kappaB] *activation* and IkappaBalpha degradation were not inhibited by rottlerin . Positive_regulation RELA IL1B 11275558 797835 Gel shift assay and an immunocytochemical study showed that N2733 inhibited induced [NF-kappaB] *activation* and its nuclear translocation . Positive_regulation RELA IL1B 11275558 797844 Our results suggest that the inhibitory action of N2733 toward *induced* [NF-kappaB] activation and iNOS expression is due to its blockade of the upstream signal ( s ) leading to IKK-alpha activation , and subsequent phosphorylation and degradation of IkappaB-alpha in rat VSMCs . Positive_regulation RELA IL1B 11385114 821632 In cells obtained before labour , in which NF-kappaB activity is low , increasing the concentration of PR represses NF-kappaB dependent transcription , while stimulation with both *increases* [NF-kappaB] activity and represses PR activity . Positive_regulation RELA IL1B 11390371 842545 Functional coupling between secretory and cytosolic phospholipase A2 modulates tumor necrosis factor-alpha- and *induced* [NF-kappa B] activation . Positive_regulation RELA IL1B 11390371 842553 We have previously shown that both secretory and cytosolic phospholipase A(2) ( PLA(2) ) are involved in TNF-alpha- and *induced* [NF-kappaB] activation . Positive_regulation RELA IL1B 11390371 842562 We show that in addition to inhibitors of secretory and cytosolic PLA(2)s , 5-lipoxygenase inhibitors attenuate TNF-alpha- and *stimulated* [NF-kappaB] activation . Positive_regulation RELA IL1B 11399097 823943 NIM had no effect on ( 1 ) *induced* increases in [NF-kappaB] or c/EBP signaling , or ( 2 ) human COX-2 promoter activity . Positive_regulation RELA IL1B 11404398 825494 Using reporter constructs and electromobility shift assays , we found that cotreatment of astrocyte cultures with ATP ( 1-100 microm ) significantly potentiated *mediated* activation of [NF-kappaB] and AP-1 and that ATP alone activated AP-1 . Positive_regulation RELA IL1B 11428868 831569 Furthermore , co-administration of U0126 and SB202190 did not affect the induced degradation of IkappaB-alpha and NF-kappaB nuclear translocation , indicating that [NF-kappaB] is *activated* by and TNF-alpha independently of activation of MEK/MAPK and p38 pathways in hRPE cells . Positive_regulation RELA IL1B 11445585 860050 In this study , we have further investigated the mechanisms of PLA(2) modulated NF-kappaB activation with respect to specific kinases involved in *stimulated* cPLA(2) phosphorylation and [NF-kappaB] activation . Positive_regulation RELA IL1B 11445585 860056 The protein kinase C ( PKC ) inhibitors RO 31-8220 , Gö 6976 , and a pseudosubstrate peptide inhibitor of atypical PKCs attenuated arachidonic acid release , cPLA(2) phosphorylation , and [NF-kappaB] activation *induced* by TNF-alpha or , thus indicating atypical PKCs in cPLA(2) regulation and transcription factor activation . Positive_regulation RELA IL1B 11445585 860074 Hence , lambda/iotaPKC regulates snpPLA ( 2 ) /LTB ( 4 ) -mediated cPLA(2) activation , cellular arachidonic acid release , and [NF-kappaB] activation *induced* by TNF-alpha and . Positive_regulation RELA IL1B 11466367 839954 It is shown that IL-1beta prevents STAT3 binding to the two STAT3-responsive sites within the alpha(2)-macroglobulin promoter by association of *activated* [NF-kappaB] to this region . Positive_regulation RELA IL1B 11466367 839956 The observation that inhibition of IL-6 induced transcriptional activation of this promoter by IL-1beta is reversed by cotransfection with I-kappaBalpha provides evidence that [NF-kappaB] *activation* by is responsible for inhibition of IL-6 mediated trans activation of the alpha(2)-macroglobulin gene . Positive_regulation RELA IL1B 11466367 839964 Additional data are provided indicating that the *activation* of [NF-kappaB] by is also responsible for the inhibition of other IL-6-inducible genes , such as the alpha(1)-antichymotrypsin gene as well as the suppressor of cytokine signaling 3 gene , suggesting a more general relevance of this mechanism for transcriptional regulation . Positive_regulation RELA IL1B 11470788 860374 IKKgamma/NEMO is an essential regulatory component of the IkappaB kinase complex that is required for [NF-kappaB] activation in *response* to various stimuli including tumor necrosis factor-alpha and . Positive_regulation RELA IL1B 11474579 841777 The -1034/+88 bp iNOS promoter was strongly *induced* by , the regulatory elements for such induction being localized downstream of -205 bp. Cotransfection experiments with NF-kappaB isoforms , IkappaB isoforms , and IKK mutants suggested that the NF-kappaB site at -115/-106 bp is important , but not sufficient , for induction of iNOS promoter and that the role of [NF-kappaB] is partially independent of its binding site . Positive_regulation RELA IL1B 11502752 868388 The results showed that Smad3 and Smad4 , but not Smad1 or Smad2 , mimicked the inhibitory effect of TGF-beta and abrogated *induced* stimulation of MMP-1 promoter activity and [NFkappaB-specific] gene transcription in dermal fibroblasts . Positive_regulation RELA IL1B 11536016 854884 Our data suggest that Pseudo-ICE and ICEBERG are intracellular regulators of caspase-1 activation and could play a role in the regulation of secretion and [NF-kappaB] *activation* during the pro-inflammatory cytokine response . Positive_regulation RELA IL1B 11574401 864927 The transcription factor [nuclear factor-kappaB (NF-kappaB)] is *activated* by , and its activity promotes the expression of several beta-cell genes , including pro- and anti-apoptotic genes . Positive_regulation RELA IL1B 11575451 865003 Extracellular stimuli , notably and tumor necrosis factor alpha (TNF-alpha) *activate* [NF-kappaB] nuclear translocation via IkappaB phosphorylation and degradation . Positive_regulation RELA IL1B 11575451 865005 These data indicate that inhibition of induced [NF-kappaB] *activation* by butyrate does not require an intact IkappaB alpha protein . Positive_regulation RELA IL1B 11583588 865682 Functional analysis of the interleukin-1-receptor associated kinase ( IRAK-1 ) in *stimulated* [nuclear factor kappa B (NF-kappa B)] pathway activation : IRAK-1 associates with the NF-kappa B essential modulator (NEMO) upon receptor stimulation . Positive_regulation RELA IL1B 11585641 866129 The data suggest that hypoxia/reoxygenation induced up-regulation of IL-1beta and IL-8 in human astrocytes has two components , a NF-kappaB independent up-regulation during hypoxia , followed by amplification through autocrine induced [NF-kappaB] *activation* during reoxygenation . Positive_regulation RELA IL1B 11641387 872128 E2 treatment of VSM cells from aged female rats inhibited both constitutive and *stimulated* [NF-kappaB] activation . Positive_regulation RELA IL1B 11641387 872132 In conclusion , our data demonstrate that constitutive and *stimulated* [NF-kappaB] activation is increased in VSM cells from aged female rats due to loss of E2 and this can be restored back to normal levels by ER-alpha gene transfer and E2 treatment . Positive_regulation RELA IL1B 11672585 872564 stimulation *caused* activation of [nuclear factor-kappaB (NF-kappaB)] and expression of cyclooxygenase-2 (COX-2) mRNA and protein , which were inhibited by daunorubicin . Positive_regulation RELA IL1B 11698503 878191 In naive cells , LPS , TNF-alpha , and *induced* IkappaBalpha degradation , kinase phosphorylation , and [NF-kappaB] DNA binding . Positive_regulation RELA IL1B 11703098 878874 While the Raf-1 activation induces a modest IkappaB degradation by enhancing the basal IkappaB kinase activity , it contradictorily suppresses the proinflammatory cytokine inducible IkappaB kinase complex , leading to an inhibition of TNF-alpha- and *induced* [NF-kappaB] activation . Positive_regulation RELA IL1B 11730360 884953 We found that both and TNF-alpha could independently *activate* cytosolic [NF-kappaB] , direct its translocation into the nucleus , and induce iNOS monomer synthesis . Positive_regulation RELA IL1B 11742864 887439 *induced* a rapid and transient activation of [nuclear factor-kappaB (NF-kappaB)] , followed by a prolonged activation of NF-kappaB that was required to induce iNOS expression . Positive_regulation RELA IL1B 11742864 887442 Transfection with antisense , but not sense , phosphorothioate modified oligodeoxynucleotides directed toward ERK also reduced induced prolonged [NF-kappaB] *activation* and iNOS expression . Positive_regulation RELA IL1B 11742864 887450 These data suggest that ERK activity is *required* for persistent [NF-kappaB] activation by that is necessary for iNOS gene expression . Positive_regulation RELA IL1B 11755929 898993 Both and TNF-alpha *stimulated* [NF-kappaB] activity , iNOS mRNA and protein expression with massive nitrite/nitrate ( NOx ) production in rat VSMCs . Positive_regulation RELA IL1B 11774033 890563 Inhibition of IL-6 activity attenuated *induced* promatrilysin , but not [NFkappaB] transactivation activity indicating that IL-6 acts downstream of NFkappaB in potentiation of IL-1beta mediated promatrilysin expression . Positive_regulation RELA IL1B 11795669 901986 Additionally , , but not CM-IL8 , *promoted* the activation of [NF-kappaB] , which has anti-apoptotic activity . Positive_regulation RELA IL1B 11828002 909562 FADD ( -/- ) MEFs were also resistant to [NF-kappa B] activation *induced* by . Positive_regulation RELA IL1B 11828002 909566 Together , these data indicate that FADD negatively regulates LPS- and *induced* [NF-kappa B] activation and that this regulation occurs upstream of I kappa B degradation . Positive_regulation RELA IL1B 11834481 911047 However , and phorbol 12-myristate 13-acetate also *activated* [NF-kappaB] but did not evoke TNF-alpha expression , revealing that this factor is not sufficient for cytokine production . Positive_regulation RELA IL1B 11912207 944620 In both cultured rat cerebellar granule cells and mouse hippocampal slices , we examined [NF-kappaB/Rel] *activation* induced by two opposing modulators of cell viability : 1 ) , which promotes neuron survival and 2 ) glutamate , which can elicit toxicity . Positive_regulation RELA IL1B 11976320 953884 In this study , we show the roles that CaMKK and Akt play in regulating *induced* [NF-kappaB] signaling . Positive_regulation RELA IL1B 11976320 953910 In human embryonic kidney 293 cells , *induces* IkappaB kinase beta (IKKbeta) activation , IkappaBalpha degradation , [NF-kappaB] transactivation , and weak Akt activation . Positive_regulation RELA IL1B 11976320 953919 A CaMKK inhibitor ( KN-93 ) and phosphatidylinositol 3-kinase inhibitors ( wortmannin and LY294002 ) do not inhibit induced [NF-kappaB] *activation* . Positive_regulation RELA IL1B 11976320 953935 However , *induced* [NF-kappaB] activity is attenuated by increased intracellular calcium in response to ionomycin , UTP , or thapsigargin or by overexpression of CaMKKc and/or Akt . Positive_regulation RELA IL1B 11976320 953988 We have also identified a novel interaction between CaMKK stimulated Akt and interleukin-1 receptor associated kinase 1 ( IRAK1 ) , which plays a key role in *induced* [NF-kappaB] activation . Positive_regulation RELA IL1B 11976320 954023 Taken together , these results indicate a novel regulatory mechanism for IL-1beta signaling and suggest that CaMKK dependent Akt activation inhibits induced [NF-kappaB] *activation* through interference with the coupling of IRAK1 to MyD88 . Positive_regulation RELA IL1B 11996950 939212 In addition , *induced* [NF-kappaB] activation in VSMC , an effect that was increased by the addition of beta-VLDL . Positive_regulation RELA IL1B 12031964 947862 Electromobility shift assays demonstrated that sodium salicylate inhibits induced [nuclear factor-kappaB (NF-kappaB)] *activation* . Positive_regulation RELA IL1B 12031968 947871 Furthermore , cFLIP overexpression increased the basal and *mediated* transcriptional activity of [nuclear factor (NF)-kappaB] , whereas it did not change cytokine induced inducible nitric oxide synthase gene transcription and nitric oxide secretion . Positive_regulation RELA IL1B 12034025 948188 Treatment of melanoma cells with capsaicin inhibited activation of constitutive and *induced* [NF-kappaB] , but not AP-1 , leading to inhibition of IL-8 expression . Positive_regulation RELA IL1B 12034569 948770 *induces* DNA binding of both [nuclear factor kappaB (NF-kappaB)] and CAATT-enhancer binding protein (C/EBP) , and activation of p38 mitogen activated protein kinase in both subpopulations . Positive_regulation RELA IL1B 12055073 951613 [NF-kappaB] *induced* by inhibits elastin transcription and myofibroblast phenotype . Positive_regulation RELA IL1B 12055073 951625 These results indicate that *activates* the nuclear localization of [NF-kappaB] that subsequently interacts with Sp1 to downregulate elastin transcription and expression of the myofibroblast phenotype . Positive_regulation RELA IL1B 12126643 966029 Electrophoretic mobility shift assays confirmed that *increased* AP-1 and [NF-kappaB] DNA binding activities in a time dependent manner . Positive_regulation RELA IL1B 12131776 966847 and TNF-alpha *increased* the [nuclear factor-kappa B (NF-kappa B)-specific] and activator protein-1-specific DNA binding activity , whereas the NF-IL6 activity was not altered . Positive_regulation RELA IL1B 12133394 966936 [NF-kappa B] in the retina can be *activated* by intraocular . Positive_regulation RELA IL1B 12167775 973506 We report that 17beta-estradiol ( E ( 2 ) ) , but not the alpha-enantiomer , inhibited the basal and *mediated* expression of the intercellular adhesion molecule type 1 ( ICAM1 ) and [NFkappaB] activation , in cultured brain endothelial cells . Positive_regulation RELA IL1B 12193729 981515 TAT-srIkappaBalpha , when exogenously added to HeLa cells , inhibited in a dose dependent manner TNF-alpha- or *induced* [NF-kappaB] activation and binding of NF-kappaB to its consensus DNA sequence . Positive_regulation RELA IL1B 12219013 986615 The 2 groups of mice were analyzed for serum levels of interferon-gamma , tumor necrosis factor-alpha , and as well as *activation* of [NFkappaB] and STAT1 , 2 proinflammatory transcription factors . Positive_regulation RELA IL1B 12220616 986967 induced *activation* of [NF-kappaB] correlated with the degradation of IkappaB-alpha in TSMCs . Positive_regulation RELA IL1B 12220616 986971 IL-1beta induced COX-2 expression and PGE ( 2 ) synthesis were completely inhibited by PD98059 ( an inhibitor of MEK1/2 ) and SB203580 ( an inhibitor of p38 inhibitor ) , but these two inhibitors had no effect on induced [NF-kappaB] *activation* , indicating that activation of p42/44 and p38 MAPK and NF-kappaB signalling pathways were independently required for these responses . Positive_regulation RELA IL1B 12237169 989143 Addition of IL-1beta activated NF-kappaB in cardiac myocytes , while CRP did not affect *induced* [NF-kappaB] activation . Positive_regulation RELA IL1B 12241537 989695 *increased* [NF-kappaB] DNA binding activity , IL-6 mRNA levels and IL-6 production . Positive_regulation RELA IL1B 12356282 993916 Treatment of cells with byakangelicol ( 50 microM ) or pyrrolidine dithiocarbamate ( PDTC ; 50 microM ) partially inhibited *induced* degradation of IkappaB-alpha in the cytosol , translocation of p65 [NF-kappaB] from the cytosol to the nucleus and the NF-kappaB-specific DNA-protein complex formation . Positive_regulation RELA IL1B 12399621 1009124 SIN-1 dose dependently inhibited the TNF-alpha- or *induced* [NF-kappaB] binding activity and suppressed the TNF-alpha induced degradation of IkappaB-alpha . Positive_regulation RELA IL1B 12417253 1012963 Treatment of cells with sphondin ( 50 microM ) or the NF-kappaB inhibitor , PDTC ( 50 microM ) partially inhibited *induced* degradation of IkappaB-alpha in the cytosol and translocation of p65 [NF-kappaB] from the cytosol to the nucleus . Positive_regulation RELA IL1B 12417253 1012965 Furthermore , *induced* [NF-kappaB-specific] DNA-protein complex formation in the nucleus was partially inhibited by sphondin ( 50 microM ) or PDTC ( 50 microM ) . Positive_regulation RELA IL1B 12421347 1013468 In comparison , *induced* the release of PGE2 , IL-6 and activated [NF-kappaB] , p38 , JNK and ERK1/2 in mixed glial cultures , but failed to induce any of these responses in microglial cell cultures . Positive_regulation RELA IL1B 12426209 1014376 However , either PDGF or EGF markedly enhanced *induced* persistent [NF-kappaB] activation and iNOS expression but did not affect the early and transient NF-kappaB activation . Positive_regulation RELA IL1B 12426209 1014384 Inhibition of ERK phosphorylation with selective inhibitors ( PD98059 or U0126 ) attenuated induced persistent [NF-kappaB] *activation* and iNOS expression in either the absence or presence of the growth factors . Positive_regulation RELA IL1B 12485902 1025165 Thalidomide inhibited *induced* [NFkappaB] transcriptional activation and IL-8 production in Caco-2 colon cancer cells . Positive_regulation RELA IL1B 12509805 1038775 Finally , and TNF-alpha *induced* degradation of NF-kappaB 's bound inhibitory protein , IkappaB-alpha , leading to translocation of [NF-kappaB] into the nucleus . Positive_regulation RELA IL1B 12517972 1039418 Unlike IL-1beta , NS-398 and Cig did not cause NF-kappaB ( p65 ) nuclear translocation , nor did they further enhance *induced* [NF-kappaB] translocation , but they stimulated PPARgamma translocation . Positive_regulation RELA IL1B 12528110 1048608 Activation of [NF-kappa B] was *induced* by , but not by MIF . Positive_regulation RELA IL1B 12528110 1048611 Anti-MIF mAb had no effect on *induced* [NF-kappa B] nuclear translocation . Positive_regulation RELA IL1B 12588520 1059442 Activation of [NF kappa B] in *response* to was no longer apparent in IL-1RI knockout mice , confirming that this receptor is essential for the transduction of IL-1 signal in the pituitary , but remained after LPS treatment . Positive_regulation RELA IL1B 12594282 1060900 In contrast , *induced* [NF-kappa B] activity and I kappa B alpha degradation were not affected by BMP-7 . Positive_regulation RELA IL1B 12594338 1064342 To further substantiate that the observed [NF-kappa B-dependent] *induction* of the human NK-1R gene is regulated via a transcriptional event through this NF-kappa B site on the NK-1R gene promoter , we transfected THP-1 cells with a luciferase promoter-reporter construct containing the 5 ' promoter region of the human NK-1R gene . Positive_regulation RELA IL1B 12603824 1062513 Caffeic acid phenethyl ester , a potent and specific inhibitor of activation of NF-kappaB , not only blocked *induced* activation of the [NF-kappaB] promoter but also decreased IL-1beta induced MIP-1alpha and -1beta expression in NT2-N cells . Positive_regulation RELA IL1B 12609991 1085314 consistently , LPS and *led* to activation of [NF kappa B] in entorhinal cortex . Positive_regulation RELA IL1B 12670873 1080136 This leads to sustained suppression of *induced* [NF-kappaB] transcriptional regulation of proinflammatory genes . Positive_regulation RELA IL1B 12681956 1077502 Glucosamine inhibits *induced* [NFkappaB] activation in human osteoarthritic chondrocytes . Positive_regulation RELA IL1B 12689943 1106078 Resveratrol blocks induced *activation* of the nuclear transcription factor [NF-kappaB] , inhibits proliferation , causes S-phase arrest , and induces apoptosis of acute myeloid leukemia cells . Positive_regulation RELA IL1B 12689943 1106080 It also suppressed the induced *activation* of transcription factor [nuclear factor kappaB (NF-kappaB)] , which modulates an array of signals controlling cellular survival , proliferation , and cytokine production . Positive_regulation RELA IL1B 12743110 1088392 We show that the induced *accumulation* of nuclear [NFkappaB] in human umbilical vein endothelial cell monolayers is dramatically reduced when polymorphonuclear leukocytes ( PMN ) are allowed to migrate across these monolayers . Positive_regulation RELA IL1B 12743110 1088399 Furthermore , cross linking of platelet-endothelial cell adhesion molecule-1 ( PECAM-1 ) , but not intercellular adhesion molecule-1 , reduces human umbilical vein endothelial cell nuclear [NFkappaB] *induced* by . Positive_regulation RELA IL1B 12744771 1088522 U937 membranes , as well as and TNF-alpha , *induced* nuclear translocation of [NF-kappaB] . Positive_regulation RELA IL1B 12745547 1088617 Finally , when the cells were exposed to Dex ( 1 microM ) prior to stimulation with IL-1beta ( 20 ng/ml ) , Dex was efficient in preventing induced [NF-kappaB] *activation* . Positive_regulation RELA IL1B 12745547 1088619 Our results indicate that , in CCRF-CEM cells , Dex prevents [NF-kappaB] activation , *induced* by , by a mechanism that involves the upregulation of IkappaB-alpha synthesis , and that depends on the early and transient activation of NF-kappaB . Positive_regulation RELA IL1B 12746898 1088818 Transient transfection experiments and EMSAs showed that induction of ESE-1 gene expression by *requires* activation of [NF-kappaB] and binding of p50 and p65 family members to the NF-kappaB site in the ESE-1 promoter . Positive_regulation RELA IL1B 12761333 1091496 Both of these agents also reduced the activation of [NF-kappaB] *induced* by LPS , tumor necrosis factor-alpha and in smooth muscle cells . Positive_regulation RELA IL1B 12799018 1100968 induced release of IL-6 and *activated* [NFkappaB] , p38 , JNK and ERK1/2 in mixed glial cultures , which was completely abolished in the presence of IL-1 receptor antagonist (IL-1ra) . Positive_regulation RELA IL1B 12839952 1108183 Electrophoretic mobility shift assay on nuclear extracts demonstrated that *induced* [NF-kappa B] DNA binding activity in HT-29 cells , and the activated NF-kappa B complex was eliminated after treatment with an inhibitor of NF-kappa B . Positive_regulation RELA IL1B 12839952 1108187 Supershift assay indicated that the two NF-kappa B subunits , p65 and p50 , were involved in *activation* of [NF-kappa B] complex by stimulation . Positive_regulation RELA IL1B 12860295 1111267 Here we demonstrate that *induces* nuclear translocation of [NF-kappaB] in human umbilical vein endothelial cells ( HUVEC ) followed by induction of cell surface expression of E-selectin , ICAM-1 and VCAM-1 , and subsequently augments adhesion of cancer cells expressing sialyl Lewis antigen , a ligand of E-selectin . Positive_regulation RELA IL1B 12860389 1111470 dependent *activation* of [NF-kappaB] mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase . Positive_regulation RELA IL1B 12873450 1114306 The objective of the study was to investigate the effects of baicalin , baicalein , and wogonin ( plant flavonoids ) on interleukin-6 (IL-6) and interleukin-8 (IL-8) protein production , mRNA expression , and [nuclear factor-kappaB (NF-kappaB)] binding activities *induced* by in human retinal pigment epithelial cell line ( ARPE-19 ) cells . Positive_regulation RELA IL1B 12923200 1151285 In addition , in neural cells in culture , this lipid messenger also inhibited both *induced* [NFkappaB] activation and cyclooxygenase-2 expression . Positive_regulation RELA IL1B 14527176 1148352 Rhein inhibits *induced* activation of MEK/ERK pathway and DNA binding of [NF-kappa B] and AP-1 in chondrocytes cultured in hypoxia : a potential mechanism for its disease modifying effect in osteoarthritis . Positive_regulation RELA IL1B 14576508 1156487 Addition of IL-1beta activated nuclear factor-kappaB (NFkappaB) in VSMCs , whereas CRP did not affect induced [NFkappaB] *activation* . Positive_regulation RELA IL1B 14581482 1186912 Without ERK activation , *induces* only acute and transient [NF-kappaB] activation . Positive_regulation RELA IL1B 14600157 1187540 [NF-kappaB] activation *induced* by tumor necrosis factor (TNF)-alpha , , and lipopolysaccharide was also inhibited by FAF1 overexpression . Positive_regulation RELA IL1B 14664905 1177726 These data indicate that therapeutic concentrations of acetaminophen induce an inhibition of *dependent* [NF-kappaB] nuclear translocation . Positive_regulation RELA IL1B 14679201 1211259 Similarly , NO attenuates induced [NF-kappaB] *activation* . Positive_regulation RELA IL1B 14691386 1179915 Stimulation of hepatocytes with *caused* a higher activation of IL-1 associated kinase , extracellular receptor activated kinases 1 and 2 , and [nuclear factor-kappaB (NF-kappaB)] in hepatocytes from alcohol fed animals than from controls . Positive_regulation RELA IL1B 14691386 1179917 Our results suggest the participation of the extracellular signal regulated kinase ( ERK ) 1/2 pathway in ethanol induced NF-kappaB activation , because treatment with PD-98059 , an ERK1/2 inhibitor , partially suppressed *induced* [NF-kappaB] expression . Positive_regulation RELA IL1B 14708613 1181166 In normal human keratinocytes PPAR agonists neither impaired IL-1beta induced translocation of p65 nor *induced* [NF-kappaB] DNA binding . Positive_regulation RELA IL1B 14746807 1182115 Investigation of the mechanism involved in MIP-1beta induction by IL-1beta showed that *activated* the [nuclear factor kappa B (NF-kappaB)] promoter in Huh7 cells . Positive_regulation RELA IL1B 14746807 1182118 In addition , caffeic acid phenethyl ester ( CAPE ) , a specific inhibitor of the activation of NF-kappaB , not only abolished mediated [NF-kappaB] promoter *activation* , but also blocked IL-1beta induced MIP-1beta expression . Positive_regulation RELA IL1B 14985981 1236667 The *activation* of [NF-kappaB] by was maximal at 20 min and declined thereafter . Positive_regulation RELA IL1B 15001568 1236967 The present study examined the effect of angiotensin II on *induced* [NF-kappaB] activation and the subsequent expression of inducible NO synthase (iNOS) and vascular cell adhesion molecule-1 ( VCAM-1 ) in cultured rat vascular smooth muscle cells . Positive_regulation RELA IL1B 15001568 1236972 The inhibitory effect of angiotensin II on iNOS expression was associated with a down-regulation of the sustained *activation* of extracellular signal regulated kinase ( ERK ) and [NF-kappaB] by , whereas the effect on VCAM-1 was independent of ERK activation . Positive_regulation RELA IL1B 15039285 1265152 Compared with free form , fibrinogen bound *stimulated* increased activation of endothelial cell [nuclear factor kappaB (NF-kappaB)] , monocyte chemoattractant protein-1 ( MCP-1 ) secretion , and nitric oxide ( NO ) synthesis . Positive_regulation RELA IL1B 15039421 1251253 These data demonstrate that caspase-1 contributes to inflammation by two distinct pathways : proteolysis of , and RIP2 dependent *activation* of [NF-kappaB] and p38 MAPK mediated by the caspase recruitment domain . Positive_regulation RELA IL1B 15044702 1228282 Expression of in AF macrophages and *activation* of [NF-kappaB] in the maternal uterus increased with the gestational increase in SP-A . Positive_regulation RELA IL1B 15044702 1228284 We propose that augmented production of SP-A by the fetal lung near term causes activation and migration of fetal AF macrophages to the maternal uterus , where increased production of *activates* [NF-kappaB] , leading to labor . Positive_regulation RELA IL1B 15056867 1230155 It was found that overexpression of Tom1 suppresses activation of transcription factors , [NF-kappaB] and AP-1 , *induced* by either or tumor necrosis factor (TNF)-alpha and that the VHS domain of Tom1 is indispensable for its suppressive activity . Positive_regulation RELA IL1B 15067222 1231910 Furthermore , induced *activation* of [nuclear factor-kappaB (NF-kappaB)] was inversely correlated with the degradation of IkappaB-alpha in HTSMCs . Positive_regulation RELA IL1B 15191916 1280941 Dexamethasone , a glucocorticoid , inhibited *induced* nuclear translocation of [NF-kappaB] and also the secretion of IL-13 from mast cells . Positive_regulation RELA IL1B 15194434 1259768 We found that differentiated Caco-2 and HT29-D4 cells were responsive to both cytokines TNFalpha- and mediated *activation* of [NF-kappaB] but that undifferentiated HT29-D4 cells were unresponsive to IL-1beta . Positive_regulation RELA IL1B 15194434 1259770 Finally , it appeared that in polarized HT29-D4 cells , the *induced* translocation of [NF-kappaB] was connected to PKCdelta translocation . Positive_regulation RELA IL1B 15208668 1281358 Electrophoretic mobility shift assay confirmed that *increased* the DNA binding activity of AP-1 and [NF-kappaB] . Positive_regulation RELA IL1B 15229109 1301847 Human breast milk suppresses the transcriptional regulation of *induced* [NF-kappaB] signaling in human intestinal cells . Positive_regulation RELA IL1B 15240151 1270121 Interestingly , *induced* [nuclear factor-kappaB (NF-kappaB)] activation in A549 cells , which was shown by increased nuclear translocation of p65 NF-kappaB and degradation of IkappaB-alpha . Positive_regulation RELA IL1B 15240151 1270126 Specifically , *induced* nuclear translocation of [NF-kappaB] was in part attenuated by LY294002 , but not by GF109203X , SB203580 , and SP600125 , suggesting PI3K dependent nuclear translocation of NF-kappaB in response to IL-1beta . Positive_regulation RELA IL1B 15269222 1290336 Inhibition of ERK1/2 , JNKs , and PKC-alpha/beta1 had no effect on NF-kappaB activation , whereas inhibition of PKC-theta and PKC-zeta inhibited *stimulated* activation of [NF-kappaB] . Positive_regulation RELA IL1B 15271652 1333121 *stimulated* the degradation of IkappaB and the activation of [NF-kappaB] but had no effect on iNOS induction . Positive_regulation RELA IL1B 15292915 1278946 Preincubation with transport peptide-PNA-NFkappaB decoy ( 1 microM , 1 h ) blocked *induced* [NFkappaB] binding activity and significantly reduced the IL-6 mRNA expression . Positive_regulation RELA IL1B 15341531 1291770 Consistently , *stimulated* translocation of [NF-kappaB] into the nucleus and degradation of inhibitory kappa B-alpha ( IkappaB-alpha ) was revealed by western blotting and immunofluorescence staining , which was blocked by helenalin , but not by U0126 , SB202190 , or SP600125 . Positive_regulation RELA IL1B 15373762 1297879 *induced* expression of phosphorylated IkappaB and the activation of [NF-kappaB] . Positive_regulation RELA IL1B 15389584 1354334 Consistently , *stimulated* translocation of [NF-kappaB] into the nucleus and degradation of IkappaB-alpha which was blocked by helenalin , U0126 , or SP600125 . Positive_regulation RELA IL1B 15390113 1304804 Caffeic acid phenethyl ester ( CAPE ) , a specific inhibitor of NF-kappaB activation , not only abrogated *induced* [NF-kappaB] promoter activation , but also blocked IL-1beta mediated induction of NK-1R gene expression . Positive_regulation RELA IL1B 15450943 1300785 Epicatechin significantly reduced IL-1beta induced nitrite production , iNOS protein and mRNA expressions , and it also inhibited *induced* IkappaBalpha protein degradation , [NF-kappaB] activation , and iNOS promoter activity . Positive_regulation RELA IL1B 15456740 1342015 However , H2O2 , tumor necrosis factor-alpha (TNF-alpha) , and significantly *increased* [NF-kappaB] activation and expression of IL-8 compared with control cells . Positive_regulation RELA IL1B 15480896 1320316 *mediated* [NFkappaB] was completely inhibited in the presence of lactacystin , a potent inhibitor of NFkappaB . Positive_regulation RELA IL1B 15489374 1359438 As expected , *stimulated* translocation of [NF-kappaB] into the nucleus and degradation of IkappaB-alpha were blocked by helenalin but not by U0126 , SB-202190 , or SP-600125 . Positive_regulation RELA IL1B 15529376 1335744 CTS of low magnitudes ( 4-8 % equibiaxial strain ) was a potent inhibitor of *dependent* [NF-kappaB] nuclear translocation . Positive_regulation RELA IL1B 15529381 1335749 *induced* DNA binding of [NF-kappaB] and AP-1 was significantly higher in hypoxic and reoxygenated cultures than in normoxia . Positive_regulation RELA IL1B 15539433 1380514 Moreover , individual boswellic acids were demonstrated to increase the basal and *stimulated* [NF-kappaB] activity in intestinal epithelial cells in vitro as well as reverse proliferative effects of IL-1beta . Positive_regulation RELA IL1B 15550384 1360971 Iron mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha induced but not *induced* [IkappaB kinase complex/nuclear] factor-kappaB activation . Positive_regulation RELA IL1B 15550384 1360976 l-Mimosine did not affect IKK and [NF-kappaB] *activation* by . Positive_regulation RELA IL1B 15662752 1350351 It became known , that oxidized LDL can inhibit LPS induced binding of the NF-kappaB to DNA and the subsequent expression of TNF-alpha and in macrophages as well as oxidized LDL modulates *activation* of [NF-kappaB] in mononuclear phagocytes by altering the degradation of I-kappaBs . Positive_regulation RELA IL1B 15695308 1382614 A77 1726 inhibited IL-1beta induced p38 and c-Jun N-terminal kinase 1/2 ( JNK1/2 ) activation , whereas A77 1726 did not affect *induced* [NF-kappaB] activation in hepatocytes . Positive_regulation RELA IL1B 15739117 1383030 consistently *increased* islet [NFkappaB] activity and c-Myc , haeme-oxygenase 1 , inducible nitric oxide synthase (iNOS) , Fas , and inhibitor of NFkappaB alpha ( IkappaBalpha ) mRNA levels . Positive_regulation RELA IL1B 15749024 1379456 Recombinant mouse *induced* strong activation of ERK1/2 , p38 , JNK and [NFkappa B] , and significant release of IL-6 and PGE2 , which was blocked by IL-1ra . Positive_regulation RELA IL1B 15758944 1432212 Incubation of rat glioma cells with the NBD peptide blocked *induced* [NFkappaB] nuclear translocation . Positive_regulation RELA IL1B 15758944 1432215 Treatment with NBD peptide completely abolished induced [NFkappaB] *activation* and Cox-2 synthesis in microvasculature . Positive_regulation RELA IL1B 15758944 1432217 These findings strongly support the hypothesis that induced [NFkappaB] *activation* plays a major role in transmission of immune signals from the periphery to the brain . Positive_regulation RELA IL1B 15820746 1393735 In the present study , using Caco-2 cells , a human enterocyte line , we demonstrate that rapidly *induces* the expression of the ASS gene at a transcriptional level through [NF-kappaB] activation . Positive_regulation RELA IL1B 15821150 1417634 *induced* [nuclear factor-kappaB (NF-kappaB)] DNA binding activity was significantly inhibited by 15d-PGJ ( 2 ) ( 10 microM ) and GW501516 ( 1 microM ) but increased with 10 microM rosiglitazone . Positive_regulation RELA IL1B 15900319 1451779 To assess whether this action is mediated by NFkappaB activation , rats were injected into the lateral ventricle of the brain with a specific inhibitor of NFkappaB activation , the NEMO Binding Domain (NBD) peptide that has been shown previously to abolish completely *induced* [NFkappaB] activation and Cox-2 synthesis in the brain microvasculature . Positive_regulation RELA IL1B 15900319 1451782 These findings strongly support the hypothesis that induced [NFkappaB] *activation* at the blood-brain interface is a crucial step in the transmission of immune signals from the periphery to the brain that underlies further events responsible of sickness behavior . Positive_regulation RELA IL1B 15901641 1445635 Curcumin ( 10 ( -8 ) M ) , which is known for inhibiting NFkappaB activation , inhibited *induced* MIF secretion as well as [NFkappaB] nuclear translocation and DNA binding . Positive_regulation RELA IL1B 15908470 1451833 In addition , EtOH significantly reduced [NF-kappaB] and AP-1 binding activity *induced* by and inhibited MCP-1 gene transcription . Positive_regulation RELA IL1B 15930438 1414562 Although the mode of action remains to be clarified , our findings support the view that the mechanism of action is via inhibition of *induced* [NF-kappaB] activation . Positive_regulation RELA IL1B 15950952 1427658 The selective impact of HDAC inhibitors on TNF-alpha induced NF-(kappa)B activation appears to relate to the fact that the TNF-alpha induced activation of NF-(kappa)B is mediated by the proteasome , whereas [NF-kappaB] *activation* by is largely proteasome independent . Positive_regulation RELA IL1B 15980221 1424669 The *activation* of [NF-kappaB] by was markedly inhibited by both triptolide and dexamethasone , whereas the activity of AP-1 was not affected by either agent . Positive_regulation RELA IL1B 16029077 1436008 Both [NF-kappaB] and AP-1 deoxyribonucleic acid binding activities were detectable in SW982 cells by EMSA , and they were *induced* by treatment . Positive_regulation RELA IL1B 16046471 1459827 In conclusion , our results indicate that 1 ) IKKbeta phosphorylates multiple p65 sites , 2 ) IKKbeta phosphorylates p65 in an IkappaB-p65 complex , and 3 ) S468 phosphorylation slightly reduces TNF-alpha- and *induced* [NF-kappaB] activation . Positive_regulation RELA IL1B 16077954 1442469 We observed that the induction of [NF-kappaB] binding activity *induced* by either or Abeta ( 25-35 ) showed a peak at 30 min , and significantly declined after 2 h . Positive_regulation RELA IL1B 16077954 1442471 The potentiating effect of Abeta ( 25-35 ) on *induced* [NF-kappaB] binding activity was observed after 30 min , 2 h and 24 h , and did not significantly differ over time . Positive_regulation RELA IL1B 16112536 1507295 *increased* nuclear activated [NF-kappaB] levels in fibroblasts and epithelial cells [ 10- and 2.5-fold over controls , respectively ( p=0.0001 ) ] , and these increases were not significantly affected by MO. PGE ( 2 ) was measured in cell supernatants by ELISA , after preincubation with MO and exposure to IL-1beta . Positive_regulation RELA IL1B 16140882 1450817 PFE also inhibited the *induced* phosphorylation of IkappaBalpha and the DNA binding activity of the transcription factor [NF-kappaB] in OA chondrocytes . Positive_regulation RELA IL1B 16148608 1455213 *induced* [NF-kappaB] activation in vascular smooth muscle cells , and the addition of GGA further inhibited this NF-kappaB activation . Positive_regulation RELA IL1B 16201298 1463892 It was concluded that the expressions of [NF-kappaB] in hRPE cells could be *increased* significantly by and depressed effectively by PDTC . Positive_regulation RELA IL1B 16201298 1463894 Also , PDTC could significantly inhibit the activation of [NF-kappaB] *induced* by . Positive_regulation RELA IL1B 16258173 1489912 Electrophorectic mobility shift assays demonstrate that is a potent *inducer* of [NF-kappaB] translocation ; Positive_regulation RELA IL1B 16286467 1509590 *induction* of [NFkappaB] is partially regulated by H2O2 mediated activation of NFkappaB inducing kinase . Positive_regulation RELA IL1B 16286467 1509604 Although IKKalpha and IKKbeta were both involved in *mediated* activation of [NFkappaB] , only the IKKalpha dependent component was modulated by changes in H2O2 levels . Positive_regulation RELA IL1B 16286467 1509634 In summary , our studies have demonstrated that redox regulation of NIK by H2O2 is mechanistically important in *induction* of [NFkappaB] activation . Positive_regulation RELA IL1B 16317111 1518958 In addition , fluvastatin increased *induced* p65 nuclear translocation and [nuclear factor kappaB (NF-kappaB)] activity , although it inhibited those induced by LPS . Positive_regulation RELA IL1B 16326073 1553813 *induced* [NF-kappaB] activation in Caco-2 cells , promoting the binding of this transcription factor to DNA and increasing NF-kappaB dependent transcription . Positive_regulation RELA IL1B 16338964 1503962 In agreement with the pharmacologic inhibition studies , siRNA directed against c-Src specifically limited c-Src protein expression and inhibited mediated *induction* of [NF-kappaB] DNA binding activity , whereas control siRNA had no effect . Positive_regulation RELA IL1B 16338964 1503966 Conversely , overexpression of constitutively active c-Src augmented basal and mediated *induction* of [NF-kappaB] DNA binding activity and NO production . Positive_regulation RELA IL1B 16339279 1539614 Chromatin immunoprecipitation analysis revealed *induced* binding of [NF-kappaB] to the PR promoter . Positive_regulation RELA IL1B 16354686 1504432 Clearance of both superoxide and H2O2 from within the endosomal compartment significantly abrogated *dependent* IKK and [NF-kappaB] activation . Positive_regulation RELA IL1B 16377638 1526969 Because several of these genes are regulated by NF-kappaB , we postulated that SAHA mediates its effects by modulating NF-kappaB and found that SAHA suppressed [NF-kappaB] activation *induced* by TNF , , okadaic acid , doxorubicin , lipopolysaccharide , H ( 2 ) O ( 2 ) , phorbol myristate acetate , and cigarette smoke ; Positive_regulation RELA IL1B 16385087 1520077 Investigation of potential signaling pathways demonstrated that metformin diminished *induced* activation and nuclear translocation of [nuclear factor-kappa B (NF-kappaB)] in SMCs . Positive_regulation RELA IL1B 16393772 1494467 This can be explained by the fact that the four effective DMARDs also suppressed induced *activation* of [nuclear factor kappa B (NF-kappaB)] , which is a crucial transcription factor for iNOS . Positive_regulation RELA IL1B 16416193 1495010 Colon tissue was collected for assessment of histological changes , [NF-kappa B] *activation* , myeloperoxidase (MPO) activity , and expression of NK-1R , SP , TNFalpha , , VCAM-1 , ICAM-1 , E-selectin , CINC-1 , MIP-1alpha , and iNOS . Positive_regulation RELA IL1B 16417227 1514530 Transcription factor ELISAs indicated that the NF-kappaB heterodimer p50-p65 binds to all three [NF-kappaB] sites in the hBD-2 promoter upon *stimulation* of primary keratinocytes with and PA . Positive_regulation RELA IL1B 16556731 1589298 [NF-kappaB] activation was induced in INS-1E cells and in 208F cells after exposure to cytokines , but apoptosis was *induced* only in INS-1E cells , with a more pronounced proapoptotic effect of than of TNF-alpha . Positive_regulation RELA IL1B 16556731 1589302 Both cytokines *induced* a prolonged ( up to 48 h ) and stable [NF-kappaB] activation in INS-1E cells , whereas induced an oscillatory NF-kappaB activation in 208F cells . Positive_regulation RELA IL1B 16569740 1568495 OTR promoter contains putative transcription factor binding sites for activating protein-1 (AP-1) , CCAAT/enhancer binding protein (C/EBP) , and [nuclear factor-kappaB (NF-kappaB)] , which may be *activated* by , whose concentrations increase with labor . Positive_regulation RELA IL1B 16569740 1568500 IL-1beta induces an increase in OTR mRNA concentrations and OTR ligand binding in myometrial cells , which is maximal at 4 h and decreased after 20 h . *activates* the transcription factors AP-1 C/EBPbeta , and [NF-kappaB] . Positive_regulation RELA IL1B 16581045 1496469 Signal transduction studies revealed that and TNF-alpha stimulation *induced* [NFkappaB] phosphorylation in A549 cells , but antagonist inhibition of NFkappaB p50-p65 phosphorylation correlated with marked reduction of IL-1beta or TNF-alpha induced CCL28 expression . Positive_regulation RELA IL1B 16597919 1589489 We previously showed that the CGRP inhibitory effect was mediated by elevated intracellular cAMP and show here that analogs of cAMP , 8-bromoadenosine 3',5'-cyclic monophosphothioate and the Sp isomer of adenosine 3',5'-cyclic monophosphothioate , mimicked the CGRP suppressive effect on induced ROS formation , [NF-kappaB] *activation* , and MCP-1 secretion . Positive_regulation RELA IL1B 16636195 1562964 A pharmacological activator of AMPK , 5-amino-4-imidazole carboxamide riboside ( AICAR ) , dose-dependently inhibited TNF-alpha- and *induced* [NF-kappaB] reporter gene expression . Positive_regulation RELA IL1B 16636588 1583080 [NF-kappaB] was *activated* within 30 min by tumor necrosis factor-alpha (TNF-alpha) or . Positive_regulation RELA IL1B 16636588 1583082 Intracellular ROS was not produced until 30 min and also antioxidants such as N-acetylcysteine and tiron had no effect on the TNF-alpha- or *induced* [NF-kappaB] activation . Positive_regulation RELA IL1B 16636588 1583085 Silymarin dose-dependently inhibited the TNF-alpha- or induced [NF-kappaB] *activation* and MCP-1 expression . Positive_regulation RELA IL1B 16636588 1583089 *Induction* of [NF-kappaB] within 30 min by TNF-alpha- and was mediated through intracellular calcium but not ROS . Positive_regulation RELA IL1B 16707097 1564051 IL-1Beta activated the extracellular signal regulated kinase 1/2 ( ERK1/2 ) , and this activation was also enhanced by H ( 2 ) S. Inhibition of ERK1/2 activation by the selective inhibitor U0126 inhibited induced [NF-kappaB] *activation* , iNOS expression , and NO production either in the absence or presence of H ( 2 ) S . Positive_regulation RELA IL1B 16707097 1564053 Our findings suggest that H ( 2 ) S enhances NO production and iNOS expression by potentiating induced [NF-kappaB] *activation* through a mechanism involving ERK1/2 signaling cascade in rat VSMCs . Positive_regulation RELA IL1B 16718462 1584926 Furthermore , C3d inhibited NCAM induced FGFR phosphorylation and apoptosis induced by IL-1beta plus IFN-gamma , but did not affect *induced* [NF-kappaB] signalling . Positive_regulation RELA IL1B 16723122 1638329 Finally , we critically review the recent data highlighting the role of ROS in [NF-kappaB] *activation* by proinflammatory cytokines ( TNF-alpha and ) and lipopolysaccharide (LPS) , two major components of innate immunity . Positive_regulation RELA IL1B 16723203 1570382 EMSA data confirm that PDCT , at concentrations sufficient to completely block IL-1beta induced HAS1 transcription , also entirely blocks *induced* [NF-kappaB] translocation . Positive_regulation RELA IL1B 16776851 1663379 Concomitantly , ALP suppressed the *induced* [NF-kappaB] activation and the upregulation of E-selectin expression in glEND.2 cells in vitro . Positive_regulation RELA IL1B 16799025 1579194 Neither IL-4 nor -13 affected the induced *activation* of [NF-kappaB] or the AP-1 component c-Jun . Positive_regulation RELA IL1B 16822942 1638576 Ribosomal S6 kinase-1 modulates *induced* persistent activation of [NF-kappaB] through phosphorylation of IkappaBbeta . Positive_regulation RELA IL1B 16822942 1638587 In conclusion , in the ERK signaling cascade , RSK1 is a key component that directly phosphorylates IkappaBbeta and contributes to the persistent *activation* of [NF-kappaB] by . Positive_regulation RELA IL1B 16840786 1606722 Treatment with SAP inhibited [NF-kappaB] activation *induced* by ; Positive_regulation RELA IL1B 16912429 1602077 Inhibition of *induced* activation of MEK/ERK pathway and DNA binding of [NF-kappaB] and AP-1 : potential mechanism for Diacerein effects in osteoarthritis . Positive_regulation RELA IL1B 16955275 1627636 As to the mechanism of inhibition , electrophoretic mobility shift assay experiments demonstrated that exposure of FLS to hyperthermia prevents *induced* [NF-kappaB] translocation and subsequent DNA binding . Positive_regulation RELA IL1B 17015748 1629898 *activated* [NF-kappaB] but not ERK or p38 . Positive_regulation RELA IL1B 17114179 1677152 Besides TNF , gamma-tocotrienol also abolished [NF-kappaB] activation *induced* by phorbol myristate acetate , okadaic acid , lipopolysaccharide , cigarette smoke , , and epidermal growth factor . Positive_regulation RELA IL1B 17126080 1677629 *induced* nuclear translocation of [NF-kappaB] ( p50 , p65 and c-Rel subunits ) , NF-IL-6 and AP-1 , each with distinct kinetics . Positive_regulation RELA IL1B 17136479 1747063 We have investigated the role of PKB and PDK1 in induced [NF-kappaB] *activation* . Positive_regulation RELA IL1B 17136479 1747070 N-tosyl phenylalanyl chloromethyl ketone ( TPCK ) , wortmannin and Ly294002 inhibited induced [NF-kappaB] *activation* in both systems indicating involvement of the PI3K axis in this response . Positive_regulation RELA IL1B 17227815 1703852 However , inhibition of the RhoA/Rho-kinase pathway did not attenuate the *activation* of [NF-kB] by . Positive_regulation RELA IL1B 17239863 1690548 [Nuclear factor kappaB (NF-kappaB)] activity was *enhanced* by and reduced by aspirin , indicating that decreased ICAM-1 and VCAM-1 expression was due to reduced NF-kappaB activity . Positive_regulation RELA IL1B 17291458 1710969 Treatment of chondrocytes with curcumin suppressed induced [NF-kappaB] *activation* via inhibition of IkappaBalpha phosphorylation , IkappaBalpha degradation , p65 phosphorylation and p65 nuclear translocation . Positive_regulation RELA IL1B 17311279 1719302 Furthermore , *stimulated* translocation of [NF-kappaB] into the nucleus and degradation of IkappaB-alpha was blocked by helenalin . Positive_regulation RELA IL1B 17337443 1726637 IRAK-4 KD cells are severely impaired in [NFkappaB] , JNK , and p38 activation in *response* to or TLR7 ligand . Positive_regulation RELA IL1B 17341614 1665061 [NF-kappaB] was *activated* by TNF-alpha , , PMA , and camptothecin in a dose dependent manner , but not by LPS . Positive_regulation RELA IL1B 17349082 1707998 In the present study , we investigated the effects of EA on the formation of intracellular reactive oxygen species , the translocation of [NFkappaB] and expression of vascular cell adhesion molecule-1 ( VCAM-1 ) , intercellular adhesion molecule-1 and endothelial leucocyte adhesion molecule ( E-selectin ) *induced* by in human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation RELA IL1B 17360530 1712735 Similarly high concentrations of each of these cytokines cross-activate the other pathway : TGFbeta activates [NFkappaB] , and *activates* Smads . Positive_regulation RELA IL1B 17390080 1716154 We have previously demonstrated that *induced* HBD-2 mRNA expression in A549 cells through activation of [nuclear factor-kappaB (NF-kappaB)] transcriptional factor as well as p38 mitogen activated protein kinase (MAPK) , c-Jun N-terminal kinase (JNK) , or phosphatidylinositol-3-kinase (PI3K) . Positive_regulation RELA IL1B 17390080 1716202 Although triptolide partially suppressed *mediated* degradation of IkappaB-alpha and nuclear translocation of p65 [NF-kappaB] , triptolide potently inhibited NF-kappaB promoter-driven luciferase activity in A549 cells . Positive_regulation RELA IL1B 17473513 1738345 Mutations of cyropyrin lead to the persistent production of and *activation* of [NF-kappaB] , followed by excessive inflammtory reactions . Positive_regulation RELA IL1B 17499220 1750900 Inhibitory effect on mediated [NF-kappaB] *activation* was evidenced by the diminishment of IkappaB kinase (IKK) phosphorylation and IkappaBalpha degradation . Positive_regulation RELA IL1B 17548806 1791969 Moreover , ST2825 interfered with recruitment of IRAK1 and IRAK4 by MyD88 , causing inhibition of *mediated* activation of [NF-kappaB] transcriptional activity . Positive_regulation RELA IL1B 17579088 1763917 EMSAs demonstrate that neither BV nor melittin blocked induced [NF-kappaB] *activation* ; Positive_regulation RELA IL1B 17645739 1793279 However , although Dex did not inhibit the nuclear translocation of p65 [NF-kappaB] in *response* to , it profoundly inhibited NF-kappaB promoter- and HBD-2 promoter-driven luciferase activities . Positive_regulation RELA IL1B 17663801 1780456 In *response* to , or IL10 , the levels of phosphorylated [NF-kappaB] and STAT3 -- respectively -- increased significantly for all the studied cell types . Positive_regulation RELA IL1B 17693924 1882310 *causes* nuclear accumulation of [NF-kappaB] ( Rel A ) but does not increase nuclear IkappaBalpha . Positive_regulation RELA IL1B 17888210 1797466 The drug reduced *induced* [NF-kappaB] and AP-1 DNA binding , as well as the phosphorylation of ERK and JNK . Positive_regulation RELA IL1B 17907174 1812703 Cyclic tensile strain rapidly inhibited the *induced* nuclear translocation of [NF-kappaB] , but not its IL-1beta induced phosphorylation at serine 276 and serine 536 , which are necessary for its transactivation and transcriptional efficacy , respectively . Positive_regulation RELA IL1B 17912472 1803867 The molecular mechanism by which RAE inhibited iNOS gene expression appeared to involve the inhibition of [NF-kappaB] activation as a *result* of RAE 's suppression of and IFN-gamma induced IkappaBalpha degradation . Positive_regulation RELA IL1B 17983423 1850443 Chondroitin sulfate reduced *induced* [NF-kappaB] nuclear translocation , but not AP-1 translocation , it decreased IL-1beta induced phosphorylation of Erk1/2 and abrogated p38MAPK phosphorylation , but did not prevent IL-1beta induced increase in nitrite . Positive_regulation RELA IL1B 18029909 1827994 Reporter gene assays showed that FXR ligands activated an FXR reporter gene and suppressed induced [nuclear factor (NF)-kappaB] *activation* and iNOS in a manner that required functional FXR and SHP . Positive_regulation RELA IL1B 18062932 1861579 Avenanthramides , polyphenols from oats , inhibit induced [NF-kappaB] *activation* in endothelial cells . Positive_regulation RELA IL1B 18239685 1871400 Here , we show that Tax1 binding protein 1 (TAX1BP1) is a negative regulator of TNF-alpha- and *induced* [NF-kappaB] activation and that binding to mono- and polyubiquitin by a ubiquitin binding Zn finger domain in TAX1BP1 is needed for TRAF6 association and NF-kappaB inhibition . Positive_regulation RELA IL1B 18260825 1895984 Existence of the canonical IKK2 [ IkappaB ( inhibitor of NF-kappaB ) kinase 2 ] /IkappaBalpha pathway of [NF-kappaB] activation *induced* by in rabbit colonic muscle cells was validated with multiple approaches , including the induction of reporter luciferase activity and endogenous NF-kappaB-target gene expression , NF-kappaB-DNA binding activity , p65 nuclear translocation , IkappaBalpha degradation and the phosphorylation of IKK2 at Ser ( 177/181 ) and p65 at Ser ( 536 ) . Positive_regulation RELA IL1B 18299187 1896726 NUMBL interacts with TAB2 and inhibits TNFalpha and induced [NF-kappaB] *activation* . Positive_regulation RELA IL1B 18300858 1873459 However , the high concentration of D-glucose did increase iNOS expression in response to low concentrations of ( 2.5 and 5 ng/ml ) , as well as the IL-1beta induced *activation* of both ERK 1/2 and [NF-kappaB] . Positive_regulation RELA IL1B 18372240 1888324 Interestingly , the anti-inflammatory cytokines IL-4 , IL-13 and IL-10 decreased *stimulated* [NFkappaB] activation and iNOS expression . Positive_regulation RELA IL1B 18375401 1899025 Diacerein and NSAIDs inhibited *stimulated* [NF-kappaB] activation in synoviocytes and chondrocytes except indomethacin in synoviocytes . Positive_regulation RELA IL1B 18378695 1906987 The compartmentalized production of superoxide ( *O ( 2 ) ( - ) ) by endosomal NADPH oxidase is important in the redox dependent *activation* of [NF-kappaB] following stimulation . Positive_regulation RELA IL1B 18389480 1899278 All the three IL enhanced the basal and *induced* transcriptional activities of [NF-kappaB] , while IL-12 and IL-27 enhanced STAT3 and STAT1 activities , respectively . Positive_regulation RELA IL1B 18467203 1921438 EMSA showed that and TNF-alpha *activated* [NF-kappaB] and AP-1 in MG-63 cells . Positive_regulation RELA IL1B 18467203 1921441 *stimulated* [NF-kappaB] via a non-canonical pathway ( p52/p65 ) and TNF-alpha via the canonical pathway ( p50/p65 ) . Positive_regulation RELA IL1B 18510099 1840591 IRAK-4 KD cells were severely impaired in [NF-kappaB] , JNK , and p38 activation in *response* to or TLR7 ligand . Positive_regulation RELA IL1B 18524861 1939831 *activated* [NF-kappaB] and increased ET-1 release in a concentration dependent manner . Positive_regulation RELA IL1B 18556347 1965895 *enhanced* the transcriptional activity of [NF-kappaB] , whereas leptin enhanced STAT1 and STAT3 activity . Positive_regulation RELA IL1B 18556347 1965907 The p38 MAPK inhibitor SB202190 suppressed IL-1beta- and IL-1beta plus leptin induced hBD-2 production , *induced* [NF-kappaB] activity , and leptin induced STAT1 and STAT3 activity ; Positive_regulation RELA IL1B 18556347 1965948 IL-1beta or leptin individually induced threonine/tyrosine phosphorylation of p38 MAPK , whereas only leptin induced tyrosine phosphorylation of JAK2 , suggesting that leptin may enhance hBD-2 production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with [NF-kappaB] , which is *activated* by . Positive_regulation RELA IL1B 18599158 2208617 and ( 3 ) S100B/RAGE induced upregulation of COX-2 , and TNF-alpha expression *requires* the concurrent activation of [NF-kappaB] and AP-1 . Positive_regulation RELA IL1B 18658272 1967185 Neither flagellin nor altered transepithelial fluxes of membrane-impermeant dextran ( 10 kDa ) or lucifer yellow ( mol wt = 457 ) , but both *activated* p38 , [NF-kappaB] , and IL-8 secretion . Positive_regulation RELA IL1B 18676628 1979509 In contrast to dexamethasone , TPCA-1 inhibited the phosphorylation and degradation of IkappaBalpha and the nuclear translocation of [NF-kappaB] *induced* by . Positive_regulation RELA IL1B 18708082 1974586 Consistently , *stimulated* both IkappaB-alpha degradation and [NF-kappaB] translocation into nucleus in these cells . Positive_regulation RELA IL1B 18772363 1985855 Because also *activates* [NF-kappaB] signaling , we investigated disparate HKalpha regulation by H. pylori and IL-1beta , testing the hypothesis that IL-1beta induced HKalpha promoter activation is mediated by the transcription factor Sp1 . Positive_regulation RELA IL1B 18779659 1963179 The stimulation of lymphoid cells with TNF-alpha , , and LPS *resulted* in significant ROS production and [NF-kappaB] activation . Positive_regulation RELA IL1B 18801189 1969507 These observations concurred with lack of a modulatory activity of IFNgamma on induced [NF-kappaB] *activation* as assessed by cellular IkappaB levels . Positive_regulation RELA IL1B 18936492 1982148 In Caco-2 cells transfected with a reporter gene for NF-kappaB activity , F. prausnitzii had no effect on *induced* [NF-kappaB] activity , whereas the supernatant abolished it . Positive_regulation RELA IL1B 19007749 2016469 Infection of FLS with Ad-IkappaB alpha ( S32A , S36A ) , an adenovirus containing mutant IkappaB alpha , inhibited *induced* nuclear translocation and DNA binding of [NF-kappaB] . Positive_regulation RELA IL1B 19056796 2017703 Moreover , cordycepin significantly inhibited *induced* p38/JNK and AP-1 activation , but not extracellular signal regulated kinase ( ERK ) and [NF-kappaB] activation . Positive_regulation RELA IL1B 19067146 2024088 The TNBS treatment caused colon shortening , increased myeloperoxidase activity , *induced* , TNF-alpha , and IL-6 expression in the colon , activated [NF-kappaB] , and potentiated the GAG degrading activities of intestinal microflora . Positive_regulation RELA IL1B 19086277 2000198 Furthermore , LGG attenuated the induced transcriptional *activation* of the IL-8 gene and the [NF-kappaB-responsive] gene , and attenuated the IL-1beta induced IkappaBalpha degradation . Positive_regulation RELA IL1B 19170127 2049007 Concomitant administration of Dex , a known NF-kappaB inhibitor , resulted in significantly down-regulated *induced* [NF-kappaB/p65] activity , as well as reduced expression of chemokine receptors and IL-17F in mouse prostate tissue . Positive_regulation RELA IL1B 19229069 2054625 Neutralization of the IL-8 receptor , CXCR2 , further induced VCAM-1 in the *presence* of , and phospho-p38 was required for [NF-kappaB] activation and VCAM-1 expression . Positive_regulation RELA IL1B 19229069 2054634 Additionally , IL-8 reduced p38 activation and [NF-kappaB] activity *induced* by alone . Positive_regulation RELA IL1B 19232515 2050521 Overexpression of FBXW5 inhibited *induced* activation of JNK/p38 MAPKs and [NF-kappaB] as well as phosphorylation of TAK1 on Thr187 . Positive_regulation RELA IL1B 19249288 2050972 Hydrogen-rich saline treatment decreased the neutrophil infiltration , the lipid membrane peroxidation , [NF-kappaB] *activation* and the pro-inflammatory cytokine interleukin and TNF-alpha in the lung tissues compared with those in saline treated rat . Positive_regulation RELA IL1B 19281832 2072887 Moreover , *stimulated* [NF-kappaB] and CaMKII phosphorylation through MyD88 dependent PI-PLC/PKCalpha/c-Src/ROS and PI-PLC/Ca2+/CaM pathways , respectively . Positive_regulation RELA IL1B 19342688 2056880 In addition , *induced* phosphorylation of downstream effectors , IkappaB kinase alphabeta , IkappaBalpha , and activation of transcription factor [NF-kappaB] was significantly reduced in the MyD88- , IRAK1- , TRAF6- , or Ras-deficient cells . Positive_regulation RELA IL1B 19347386 2128096 The Deltapsim of hepatocytes was markedly decreased after IL-1beta stimulation which was significantly attenuated by Gln at 5 and 10 mmol/l . [NF-kappaB] activity was *increased* by stimulation and this effect was augmented by Gln at 5 and 10 mol/l . Positive_regulation RELA IL1B 19410980 2075263 Moreover , it suppressed induced [NF-kappaB] *activation* , including NF-kappaB dependent reporter gene expression in a dose dependent manner . Positive_regulation RELA IL1B 19423159 2089903 Cx43 liposomes containing a soluble NEMO binding domain peptide suppressed the intracellular signaling cascade *induced* [NF-kappaB] activation and cyclooxygenase-2 expression in Cx43 expressing cells , confirming effective peptide transfer into the cell . Positive_regulation RELA IL1B 19446813 2141904 Furthermore , digitoxin prevented the induced *activation* of p44/42-MAPK and [NF-kappaB] without affecting activation of JNK and p38-MAPK . Positive_regulation RELA IL1B 19451246 2096982 PAK DeltafliC also inhibited [NF-kappaB] *induced* by and Toll-like receptor 2 agonist Pam3CSK4 . Positive_regulation RELA IL1B 19521662 2108925 Transforming growth factor-beta activated kinase 1 ( TAK1 ) is a serine/threonine protein kinase that is critically involved in the *activation* of [NF-kappaB] by tumor necrosis factor ( TNFalpha ) , and TLR ligands . Positive_regulation RELA IL1B 19607676 2112180 Inhibition of [nuclear factor kappa B (NF-kappaB)] activation *induced* by and IFN-gamma was investigated . Positive_regulation RELA IL1B 19625606 2131260 We conclude that IL-1alpha and act via an oxidant- and AKT/Foxo independent mechanism to activate p38 MAPK , *stimulate* [NF-kappaB] signaling , increase expression of atrogin1/MAFbx and MuRF1 , and reduce myofibrillar protein in differentiated myotubes . Positive_regulation RELA IL1B 19672968 2182998 *stimulated* IkappaBalpha degradation , [NF-kappaB] nuclear translocation , and transactivation in astrocytes . Positive_regulation RELA IL1B 19765584 2153538 Likewise , NAC only inhibited *stimulated* [NF-kappaB] activation in synoviocytes . Positive_regulation RELA IL1B 19836480 2203160 Curcumin blocks *induced* proteoglycan degradation , [AP-1/NF-kappaB] signalling , chondrocyte apoptosis and activation of caspase-3 . Positive_regulation RELA IL1B 19887769 2197290 Both TNF-alpha and *activated* [NF-kappaB] and stimulated IL-8 production . Positive_regulation RELA IL1B 19921217 2203715 The influence of NFkappaB inhibitors ( dexamethasone , pyrrolidine dithiocarbamate ( PDTC ) and BAY 11-7082 ) on *induced* [NFkappaB] transcriptional activity was investigated by transient transfection of Caco-2 cells with an NFkappaB secreted alkaline phosphatase reporter plasmid . Positive_regulation RELA IL1B 19929594 2171916 IFN-gamma does not affect the transient *activation* of classical [NF-kappaB] by and synergistic induction of ip-10 expression by IFN-gamma and IL-1beta occurs even after the activation of classical NF-kappaB has returned to basal levels . Positive_regulation RELA IL1B 19962969 2204170 Both LT and DN-p38 decreased *induced* [NF-kappaB] luciferase activity . Positive_regulation RELA IL1B 20038579 2205273 Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and *induced* [IKK/NF-kappaB] and JNK/AP-1 activation . Positive_regulation RELA IL1B 20039418 2192710 Fasudil inhibited induced *activation* of [NF-kappaB] independent of the inhibition of IkappaBalpha degradation and nuclear translocation of NF-kappaB , and inhibited IL-1beta induced DNA binding of NF-kappaB . Positive_regulation RELA IL1B 20067961 2241608 Although both glucose and cream induce [NF-kappaB] binding and an increase in the expression of SOCS3 , TNF-alpha , and in MNCs , only cream *caused* an increase in LPS concentration and TLR-4 expression . Positive_regulation RELA IL1B 20116443 2258841 C4S inhibited the enhanced expression of COX-2 and mPGES1 but had no effect on the *induced* decrease of I-kappaBalpha and nuclear translocation of [NF-kappaB] . Positive_regulation RELA IL1B 20145375 2280998 ( 4 ng/ml , 10 min ) *induced* phosphorylation of [NF-kappaB] , JNK , and ERK . Positive_regulation RELA IL1B 20145375 2281001 Angiotensin II augmented the *induced* phosphorylation of ERK but not [NF-kappaB] and JNK . Positive_regulation RELA IL1B 20181058 2222753 potently *induced* [NF-kappaB] activation in CaCo-2 cells , but did not induce TLR-4 expression . Positive_regulation RELA IL1B 20222108 2265580 *Enhancement* of [NF-kappaB] activation by adiponectin as well as by was observed in RASFs . Positive_regulation RELA IL1B 20432452 2268151 Moreover , *stimulated* [NF-kappaB] p65 translocation was blocked by helenalin , but not by U0126 or SP600125 , revealing that MAPKs and NF-kappaB pathways were independent on these responses . Positive_regulation RELA IL1B 20484576 2288698 PLK1 inhibits [NF-kappaB] transcriptional activation *induced* by TNF-alpha , , or several activators , but not by nuclear transcription factor p65 . Positive_regulation RELA IL1B 20525168 2284218 We have shown that *induced* miR-146a expression in HASM and that this was regulated at the transcriptional level by [NF-kappaB] and at the post-transcriptional level by the MEK-1/2 and JNK-1/2 . Positive_regulation RELA IL1B 20543863 2308296 Our results suggest that membranous L1CAM interacts with RGD binding integrins , leading to sustained [NF-kappaB] *activation* by production and autocrine/paracrine signalling . Positive_regulation RELA IL1B 20600535 2316085 Moreover , *induced* activator protein-1 (AP-1) and [nuclear factor-kappaB (NF-kappaB)] activation were inhibited by luteolin . Positive_regulation RELA IL1B 20717945 2312998 *increased* [nuclear factor (NF)-kappaB] activation and nuclear translocation . Positive_regulation RELA IL1B 23136298 2729443 As expected , *induced* [NFKB] transcriptional activity . Positive_regulation RELA IL1B 23452206 2787388 Cigarette smoke condensate extracts *induce* production from rheumatoid arthritis patient derived synoviocytes , but not osteoarthritis patient derived synoviocytes , through aryl hydrocarbon receptor dependent [NF-kappa-B] activation and novel NF-kappa-B sites . Positive_regulation RELA IL1B 24009751 2836892 Earlier we reported that *activated* [NFkB] down-regulates gastrin , the major hormonal regulator of acid secretion . Positive_regulation RELA IL1B 24009751 2836896 In this study , the probable pathway by which *induces* [NFkB] and affects gastrin expression has been elucidated . Positive_regulation RELA IL1B 7540991 310185 N , N,N-trimethylsphingosine inhibits *induced* [NF-kappa B] activation and consequent E-selectin expression in human umbilical vein endothelial cells . Positive_regulation RELA IL1B 7540991 310189 Electrophoretic mobility shift assay revealed that TMS inhibited induced [NF-kappa B] *activation* , which is essential for E-selectin expression . Positive_regulation RELA IL1B 7545088 318479 Here we demonstrate that *induces* nuclear translocation of [NF kappa B] in human umbilical vein endothelial cells , followed by induction of cell surface expression of E-selectin , intercellular adhesion molecule-1 , and vascular adhesion molecule 1 , and subsequently augments adhesion of those cancer cells expressing sialyl Lewis X antigen , a ligand to E-selectin . Positive_regulation RELA IL1B 7556162 327630 [NF-kappa B] is also *activated* by in HUVE cells , but this activation occurs without increased PKR autophosphorylation or eIF2 alpha phosphorylation . Positive_regulation RELA IL1B 7589098 334010 IL-4 was also found partially to inhibit [NF kappa B] activity *induced* by tumor necrosis factor-alpha (TNF-alpha) and . Positive_regulation RELA IL1B 7864166 296332 increases laminin B2 chain mRNA levels and *activates* [NF-kappa B] in rat glomerular epithelial cells . Positive_regulation RELA IL1B 8074648 270513 Using the insulin producing rat cell line RINm5F and an electrophoretic mobility shift assay ( EMSA ) , it was presently found that *induced* a rapid activation ( 5 min ) of the transcription factor [NF-kappa B] and that this event was prevented by the protease inhibitor N alpha-p-tosyl-L-lysine chloromethylketone ( TLCK ) . Positive_regulation RELA IL1B 8074713 270572 In human astrocytoma and neuroblastoma cell lines tumour necrosis factor alpha (TNF alpha) and *induced* [NFKB] and an additional KB-specific protein of approximately 80 K to bind the HIV-1 enhancer . Positive_regulation RELA IL1B 8579596 350553 Tyrosine kinase inhibitors , genistein and herbimycin A , do not block induced *activation* of [NF-kappa B] in rat mesangial cells . Positive_regulation RELA IL1B 8579596 350557 Since both COX-2 and iNOS promoters have a kappa B binding motif , we have evaluated the effects of tyrosine kinase inhibitors on *induced* [nuclear factor-kappa B (NF-kappa B)] activation by electromobility shift assays . Positive_regulation RELA IL1B 8579596 350561 rapidly *induced* the translocation of [NF-kappa B] in rat mesangial cells . Positive_regulation RELA IL1B 8579596 350563 These data suggest that an upstream tyrosine kinase pathway may not be required for induced [NF-kappa B] *activation* and that the tyrosine kinase pathway may converge with the NF-kappa B pathway down-stream of NF-kappa B activation in rat mesangial cells . Positive_regulation RELA IL1B 8621602 354195 C2-ceramide and sphingomyelinase induced [NF-kappaB] activation by themselves and enhanced *activation* by , which is essential for E-selectin expression . Positive_regulation RELA IL1B 8626526 360414 Binding to the [NF-kappaB] element was strongly *induced* by , but not by acetylsphingosine or PMA . Positive_regulation RELA IL1B 8809309 383097 The aim now was to investigate whether recombinant ( r ) *induces* the stimulation of [NF kappa B] and its inhibitor proteins in human gingival fibroblasts and to understand if inhibition of its activity affects collagenase gene expression . Positive_regulation RELA IL1B 8830655 385505 We found that binding of [NFkappaB] is strongly *induced* in mesangial cells by both and TNF-alpha . Positive_regulation RELA IL1B 8863511 388845 Here , we describe that both and TNF alpha *activate* the transcription factor [nuclear factor-kappa B (NF-kappa B)] via production of reactive oxygen intermediates resulting in ACT expression . Positive_regulation RELA IL1B 8943367 399992 In addition , expression of a dominant negative rac1 mutant ( N17rac1 ) inhibits basal and *stimulated* [NF-kappaB] activity . Positive_regulation RELA IL1B 8977194 408710 *stimulated* [NF-kappaB] nuclear translocation and NF-kappaB dependent IL-1beta and IL-8 expression in both Caco-2 and HT-29 cells as assayed by electrophoretic mobility shift assay , immunofluorescence , kappaB-luciferase transfection , reverse transcriptase-PCR analysis and ELISA . Positive_regulation RELA IL1B 8977194 408712 These data show that *induces* [NF-kappaB] activity and expression of NF-kappaB dependent genes in colonic epithelial cells and suggest altered regulation of IkappaB alpha degradation compared with other cell lineages , which may result in their increased responsiveness to therapeutic blockade . Positive_regulation RELA IL1B 8986132 404011 Moreover , ebselen did not prevent induced [NF-kappa B] *activation* . Positive_regulation RELA IL1B 9022680 405596 In this report , we first demonstrated that is a potent *activator* of [NF-kappa B] in various epithelial transformed cell lines ( OVCAR-3 , SKOV-3 , MCF7 A/Z ) . Positive_regulation RELA IL1B 9022680 405599 We showed that mediated *induction* of [NF-kappa B] in OVCAR-3 and in other epithelial cell lines does not proceed through the production of reactive oxygen intermediates , while the same cytokine activates NF-kappa B in lymphoid cells through the intracellular generation of H2O2 . Positive_regulation RELA IL1B 9041934 416036 rapidly *stimulated* the translocation of the p65 , p50 , and c-rel [NF-kappa B] subunits from the cytoplasm to the nucleus . Positive_regulation RELA IL1B 9299557 453827 However , A20 mutants that no longer associated with 14-3-3 proteins could still fully inhibit [NF-kappaB] activation *induced* by tumor necrosis factor , or phorbol 12-myristate 13-acetate , thus excluding a crucial role for 14-3-3 interaction in this A20 function . Positive_regulation RELA IL1B 9323084 456530 Radioligand binding and electrophoretic mobility shift assays showed that during chronic hypoxia , IL-1 receptor density and activity of the transcription factor [NF-kappaB] *induced* by were decreased , which may account at least in part for the decrease in iNOS expression . Positive_regulation RELA IL1B 9331934 457590 In the present study using primary human fetal astrocyte cultures , we found that *stimulated* activation of [nuclear factor kappa B (NF-kappa B)] within 2 h , iNOS mRNA expression at 8 h , and maximal NO production by 5 days post-treatment . Positive_regulation RELA IL1B 9332715 457653 The oxidative stress responsive transcription factor [nuclear factor-kappa B (NF-kappa B)] consists of a p50 ( 50 kDa ) and p65/RelA ( 65 kDa ) component and can be *activated* in vitro by TNF alpha , , hydrogen peroxide and oxygen radicals . Positive_regulation RELA IL1B 9337212 458225 In contrast , superoxide dismutase did not inhibit the *induced* [NF-kappaB] activation . Positive_regulation RELA IL1B 9436821 474861 Thiopental did not affect the *stimulated* activation of [NF-kappaB] in VSMCs . Positive_regulation RELA IL1B 9506955 491507 However , *induced* IkappaBalpha degradation as well as [NF-kappaB] nuclear translocation and DNA binding , as determined by Western blot and electro-mobility shift assay , respectively , are not affected by these inhibitors . Positive_regulation RELA IL1B 9523575 493935 Promoter deletion analysis revealed that induced IL-6 expression *required* the transcription factor [nuclear factor-kappaB (NF-kappaB)] , whereas SP- and histamine induced IL-6 synthesis was essentially controlled by NF-IL-6 . Positive_regulation RELA IL1B 9568691 501339 TLCK and MG 132 inhibited both *induced* activation of [NFkappaB] and degradation of IkappaBalpha by islets and RINm5F cells . Positive_regulation RELA IL1B 9588901 504696 [NF-kappaB] activation during IgG immune complex induced lung injury : *requirements* for TNF-alpha and but not complement . Positive_regulation RELA IL1B 9652398 515851 Effect of dexamethasone on *induced* [nuclear factor-kappaB (NF-kappaB)] and kappaB dependent transcription in epithelial cells . Positive_regulation RELA IL1B 9652398 515853 Similarly , BEAS-2B cells showed no effect of dexamethasone on *induced* [NF-kappaB] ( p50/p65 ) . Positive_regulation RELA IL1B 9662438 518261 Human/mouse interleukin-1 receptor/receptor accessory protein interactions in *induced* [NFkappaB] activation . Positive_regulation RELA IL1B 9662438 518266 In non transfected C127 cells , signalled through the mIL-1RI-mIL-1RAcP complex and *activated* [NFkappaB] p50/p65 heterodimers . Positive_regulation RELA IL1B 9662438 518272 In C127-hIL-1RI cells , signalled through the hIL-1RI and *activated* both p65/p65 and p50/p65 [NFkappaB] complexes , where only the activation of NFkappaB p65/p65 was dependent on mIL-1RAcP . Positive_regulation RELA IL1B 9681388 521141 With the aim of investigating the importance of the IL-1RAcP in IL-1 signalling , IL-1alpha and IL-1beta induced febrile responses and *mediated* activation of [NFkappaB] in primary astrocyte cultures were examined using IL-1RAcP-deficient ( IL-1RAcP KO ) and wild type mice , respectively . Positive_regulation RELA IL1B 9681388 521143 Furthermore , it was shown that rhIL-1beta activated , in a concentration dependent manner , nuclear translocation of the transcriptional nuclear factor kappa B (NFkappaB) in primary astrocyte cultures prepared from wild type mice , whereas no *induced* translocation of [NFkappaB] could be detected in cultures prepared from IL-1RAcP-deficient mice , as revealed by electrophoretic mobility shift assay ( EMSA ) . Positive_regulation RELA IL1B 9727370 529924 Electrophoretic mobility shift assays ( EMSA ) showed that and tumor necrosis factor-alpha *activated* [NF-kappaB] from 15 min to 48 h after stimulation . Positive_regulation RELA IL1B 9754830 535235 In these cells IFN-gamma potentiation is mostly mediated by GAS and ISRE , suggesting a role for the IFN-gamma induced transcription factors Stat1alpha ( which binds GAS ) and IRF-1 ( which binds ISRE ) , which may cooperate with [NF-kappaB] *induced* by for iNOS activation . Positive_regulation RELA IL1B 9759860 536571 *Activation* of [NF-kappaB] by was markedly less sensitive to both cPLA2 and sPLA2 inhibitors . Positive_regulation RELA IL1B 9794459 543060 Neutral SMase , , and TNF alpha *activated* [NF-kappaB] , as revealed by electrophoretic mobility shift assay , and its nuclear translocation , as demonstrated by immunocytochemical study . Positive_regulation RELA IL1B 9812920 545989 Electrophoretic mobility shift assay using synthetic oligonucleotide corresponding to the downstream NF-kappaB site of rat iNOS promoter as a probe showed that NOR3 inhibited induced [NF-kappaB] *activation* and its nuclear translocation , as demonstrated with immunocytochemical study . Positive_regulation RELA IL1B 9950608 589837 TNF-alpha , , and TII but not IFN-gamma alone caused degradation of I kappaB , Rel A nuclear translocation , and *increased* [NF-kappaB] DNA binding activity , effects that were blocked by pretreatment with MG-132 . Positive_regulation RELA IL1R2 10383449 624596 Because it has been shown that members of the TRAF family are involved in *activation* of [NF-kappaB] and the c-Jun N-terminal kinase (JNK) by the and members of the TNF receptor superfamily , a role of TRAF1 in receptor cross-talk and/or feedback regulation of activated receptor signaling complexes can be suggested . Positive_regulation RELA IL1R2 19679662 2144289 Moreover , overexpression of a green fluorescent protein ( GFP ) -tagged mini-MyD88 protein ( GFP-MyD88- ( 27-72 ) ) , comprising the Glu ( 52 ) and Tyr ( 58 ) residues , interfered with recruitment of both IRAK1 and IRAK4 by MyD88 and suppressed [NF-kappaB] *activation* by the but not by the MyD88 independent TLR3 . Positive_regulation RELA IL1RL1 7629057 316542 Moreover , expression of the membrane bound protein in transiently transfected Jurkat cells did not *result* in activation of the transcription factor [NF-kappa B] following IL-1 beta treatment . Positive_regulation RELA ITGB2 11701612 878736 dependent *activation* of [NF-kappaB] was potentiated by wild-type , and attenuated by dominant negative , TRAF6- and TGF-beta activated kinase ( TAK1 ) constructs . Positive_regulation RELA ITGB2 12600815 1099100 IL-3 , IL-5 , and GM-CSF could enhance p38 MAPK and [NF-kappaB] activity and *induce* ICAM-1 , CD11b , and expressions on eosinophils . Positive_regulation RELA ITGB2 14613935 1187981 Co-stimulating and CD11b with activating antibodies *resulted* in [NF-kappaB] activation by GM-CSF and IL-8 in suspended cells . Positive_regulation RELA ITGB2 15886116 1406851 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , *activation* of the [NF-kappaB] transcription factor , inside-out activation of the integrin , TCR clustering , and polarisation of the T cell . Positive_regulation RELA ITGB2 9062344 417865 dependent oxidative [NF-kappaB] *activation* leading to nitric oxide production in rat Kupffer cells cocultured with syngeneic hepatoma cells . Positive_regulation RELA JAG1 10329626 613628 Both c-Rel and [RelA] *induced* gene expression , whereas a mutant defective for transactivation did not . Positive_regulation RELA JAG1 12107827 963115 mediated activation of notch signaling *induces* complete maturation of human keratinocytes through [NF-kappaB] and PPARgamma . Positive_regulation RELA LBP 16123407 1449375 Combined stimulation with LPS and either sCD14 or also *induced* the phosphorylation and degradation of IkappaB-alpha and the translocation of [NF-kappaB] from the cytoplasm to the nucleus of corneal fibroblasts . Positive_regulation RELA LBP 20615568 2309986 Despite activating NFkappaB , NOD1 ligand did not upregulate hepatocyte production of the acute phase proteins lipopolysaccharide binding protein , serum amyloid A , or soluble CD14 in cell culture supernatants , or upregulate mRNA expression of , serum amyloid A , C-reactive protein , or serum amyloid P . NOD2 ligand ( MDP ) did not *activate* hepatocytes when given alone , but did synergize with Toll-like receptor ligands , lipopolysaccharide (LPS) , and polyI : C to activate [NFkappaB] and MAPK . Positive_regulation RELA MAP2K6 10878013 722396 A constitutive active -- > ERK pathway negatively *regulates* [NF-kappa B-dependent] gene expression by modulating TATA binding protein phosphorylation . Positive_regulation RELA MAP2K6 11157486 780793 These studies suggest that the induced expression of TF by OSM is primarily through the *activation* of [NF-kappaB] and that activation of NF-kappaB is regulated in part by the signal transduction pathway . Positive_regulation RELA MAP2K6 11741913 904999 Analyzing the effects of several inhibitors or mutant receptors revealed that this [NF-kappa B] activation is *mediated* neither by nor by the phosphatidylinositol 3-kinase pathway but by STAT5 . Positive_regulation RELA MAP2K6 11885780 894116 The activations of CREB and [NF-kappaB] were *blocked* by inhibitors of either p38 ( SB-203580 ) or ( PD-098059 ) , suggesting that they were events downstream of MAK kinase . Positive_regulation RELA MAP2K6 15652235 1364151 PD98059 , a inhibitor , and BAY 11-8702 , an I kappa B-alpha inhibitor , *reduced* ERK and [NF-kappa B] cascade activation , respectively , with little effect on PKC phosphorylation . Positive_regulation RELA MAP2K6 16467309 1548230 Activation of PAR-1 or PAR-2 promoted nuclear translocation and phosphorylation of [p65-NF-kappaB] , and thrombin induced but not PAR-2 induced p65-NF-kappaB phosphorylation was *reduced* by inhibition of or p38MAPK . Positive_regulation RELA MAP2K6 17274000 1697331 Inhibitors of PI3 K , p38 MAPK , and *suppressed* IL-18 plus IFN-gamma induced CXCL9 , CXCL10 , and CXCL11 production and [NF-kappaB] , STAT1 , and IRF-1 activities . Positive_regulation RELA MAP2K6 18834856 1981696 The specific inhibitor , U0126 , significantly *blocks* TRAIL mediated [NF-kappaB] activation and subsequent MMP-9 induction . Positive_regulation RELA MAP2K6 9525929 495487 *activates* myocardial cell [NF-kappaB] and inhibits apoptosis in a p38 mitogen activated protein kinase dependent manner . Positive_regulation RELA MMP28 17907155 1812647 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not *prevent* HGF induced ERK-1/2 phosphorylation and [NF-kappaB] activity , but significantly restored HGF inhibited collagen and CTGF accumulation . Positive_regulation RELA MMP7 17907155 1812663 Inhibition of activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not *prevent* HGF induced ERK-1/2 phosphorylation and [NF-kappaB] activity , but significantly restored HGF inhibited collagen and CTGF accumulation . Positive_regulation RELA NEDD9 13679070 1140267 Our findings suggest that is *involved* in Casper mediated regulation of apoptosis and [NF-kappaB] activation . Positive_regulation RELA NES 9427296 472701 Furthermore , in cells pulsed with TNF , a treatment which favors nuclear accumulation of newly synthesized IkappaBalpha , expression *promoted* sustained accumulation of nuclear [NF-kappaB] lacking DNA binding activity . Positive_regulation RELA NES 9427296 472703 This *mediated* accumulation of inactive nuclear [NF-kappaB] is likely the consequence of interference in the IkappaBalpha mediated export of NF-kappaB . Positive_regulation RELA PECAM1 19390054 2094939 Inward remodeling was associated with *dependent* [NFkappaB] activation , surface adhesion molecule expression , and leukocyte infiltration as well as Akt activation and vascular cell proliferation . Positive_regulation RELA PECAM1 20173029 2215492 *had* no effect on the phosphorylation of the [NF-kappaB] inhibitory protein , IkappaBalpha ; Positive_regulation RELA PIGR 20450283 2257172 Induction of expression in HT-29 cells *required* [NF-kappaB] signaling but not MAPK signaling , in contrast to the requirement for both NF-kappaB and MAPK signaling for induction of pro-inflammatory genes . Positive_regulation RELA PLAT 17717150 1801553 In conclusion , our results demonstrate that after MCAO the interaction between and LRP *results* in [NF-kappaB] activation in astrocytes and induction of inducible nitric-oxide synthase expression in the ischemic tissue , suggesting a cytokine-like plasminogen independent role for tPA during cerebral ischemia . Positive_regulation RELA PLAU 10467400 640769 We report that the ( uPA ) , one of the critical proteases involved in tumor invasion and metastasis , is overexpressed in pancreatic tumor cells and its overexpression is *induced* by constitutive [RelA] activity . Positive_regulation RELA PLAU 11689575 903860 The urokinase-type plasminogen activator ( uPA ) promoter contains an NF-kappaB binding site , and expression in MDA-MB-231 cells is *induced* by the constitutively active [NF-kappaB] . Positive_regulation RELA PLAU 12759445 1091212 In particular , *increased* LPS induced activation of intracellular signaling pathways , including Akt and c-Jun N-terminal kinase , nuclear translocation of the transcriptional regulatory factor [NF-kappa B] , and expression of proinflammatory cytokines , including IL-1 beta , macrophage-inflammatory protein-2 , and TNF-alpha . Positive_regulation RELA PLAU 17200110 1702349 In this report , we show that KGF/FGF-7 activated [nuclear factor kappaB (NF-kappaB)] , which in turn *induced* expression of VEGF , MMP-9 , and and increased migration and invasion of KGF/FGF-7 stimulated human pancreatic ductal epithelial cells . Positive_regulation RELA PLAU 1905804 161663 Our results suggest that maximal transcriptional activation of the gene by PMA , IL-1 and TNF alpha *requires* the induction of [NFkB] activity and the decay of a short lived repressor protein , possibly IkB . Positive_regulation RELA PLAU 21426933 2427297 Downregulation of and uPAR , simultaneously by transfecting the cancer cells with bi-cistronic siRNA expressing plasmid ( pU ) *inhibited* radiation induced ERK activation , nuclear translocation of [Rel-A] , NF-?B DNA binding activity , and MCP-1 expression . Positive_regulation RELA PTGER2 20516073 2295218 Shear induced interleukin-6 synthesis in chondrocytes : *roles* of and EP3 in cAMP/protein kinase A- and PI3-K/Akt dependent [NF-kappaB] activation . Positive_regulation RELA RCAN1 17062574 1654647 To elucidate the molecular basis of these anti-inflammatory effects , we analyzed the *role* of in the regulation of [NF-kappaB] transactivation using glioblastoma cells stably transfected with DSCR1 .4 or its truncation mutants ( DSCR1.4- ( 1-133 ) and DSCR1 .4- ( 134-197 ) ) . Positive_regulation RELA RCAN1 19716405 2158177 also *stimulated* IL-1R mediated signaling pathways , TAK1 activation , [NF-kappaB] transactivation , and IL-8 production , all downstream consequences of IL-1R activation . Positive_regulation RELA S100B 15590067 1346034 On the other hand , *stimulated* [NF-kappaB] transcriptional activity in BV-2 microglia in a manner that was strictly dependent on RAGE transducing activity , pointing to additional , RAGE mediated effects of the protein on microglia that remain to be investigated . Positive_regulation RELA S100B 18599158 2208615 and ( 3 ) induced upregulation of COX-2 , IL-1beta and TNF-alpha expression *requires* the concurrent activation of [NF-kappaB] and AP-1 . Positive_regulation RELA S100B 20069545 2201284 Conversely , silencing expression in myoblast cell lines by RNA interference *resulted* in reduced [NF-kappaB] activity and enhanced MyoD , myogenin and MyHC expression and myotube formation . Positive_regulation RELA SPHK1 16038795 1437476 Suppression of activation led to reduction of cytokine induced IkappaBalpha phosphorylation and consequently *diminished* [NFkappaB] activity due to reduced nuclear translocation of RelA ( p65 ) , explaining the dependence of inflammatory mediator production on SPHK1 activation . Positive_regulation RELA SPON2 20205276 2223014 expression is upregulated during intestinal inflammation and may *induce* [NF-kappaB] promoter activation in a TLR-9 mediated manner . Positive_regulation RELA STK39 10485710 644384 [NF-kappaB] activation by tumour necrosis factor *requires* the Akt . Positive_regulation RELA STK39 10485710 644445 Here we show that the Akt is *involved* in the activation of [NF-kappaB] by tumour necrosis factor (TNF) . Positive_regulation RELA STK39 11945026 930039 The , IKK beta , can *mediate* [NF- kappa B] activation although several alternative pathways exist . Positive_regulation RELA TGM2 15471861 1342453 We found that *activates* the transcriptional activator [nuclear factor (NF)-kappaB] and thereby enhances LPS induced expression of inducible nitric-oxide synthase . Positive_regulation RELA TGM2 16720350 1565296 Previously we showed that the overexpression of *resulted* in activation of [NF-kappaB] through polymerization of I-kappaBalpha . Positive_regulation RELA TGM2 16987813 1640589 Recently we reported that *activates* [nuclear factor-kappaB (NF-kappaB)] independently of I-kappaB kinase (IKK) activation , by inducing cross linking and protein polymer formation of inhibitor of nuclear factor-kappaBalpha ( I-kappaBalpha ) . Positive_regulation RELA TGM2 17108131 1645502 We recently showed that *activated* [NF-kappaB] through polymerization and depletion of free IkappaBalpha during inflammation . Positive_regulation RELA TGM2 17108131 1645506 Therefore , increased expression of and subsequent *activation* of [NF-kappaB] may contribute to drug resistance in breast cancer cells independently of EGF signaling . Positive_regulation RELA TGM2 18923241 1977479 The objective of the present study was to investigate the expression of in the human atherosclerotic human coronary artery , and the possible *roles* of TGase 2 in [NF-kappaB] activation . Positive_regulation RELA TGM2 18950638 1989225 Furthermore , expression synergistically *increases* [NF-kappaB] activity with canonical pathway . Positive_regulation RELA TLR7 11909531 923658 MyD88 is an adaptor protein that is involved in interleukin-1 receptor (IL-1R)- and *induced* activation of [NF-kappaB] . Positive_regulation RELA TLR7 11937546 928153 IL-1R associated kinase (IRAK) plays a pivotal role in mediated signaling and [NF-kappaB] *activation* . Positive_regulation RELA TLR7 12133979 967124 Moreover , various ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* [NF-kappa B] activation and up-regulated TNF-alpha production in osteoclast precursor cells . Positive_regulation RELA TLR7 12471095 1023009 A dominant negative form of TRIF inhibited TLR2- , TLR4- , and *dependent* [NF-kappaB] activation . Positive_regulation RELA TLR7 12792852 1097925 After stimulation , recruits IL-1R associated kinase via adaptor myeloid differentiation factor 88 ( MyD88 ) and *induces* activation of [NF-kappaB] and mitogen activated protein kinases . Positive_regulation RELA TLR7 12885415 1116673 MyD88 ( S ) is not able to activate NF-kappaB , and in contrast functions as a dominant negative inhibitor of *induced* [NF-kappaB] activation . Positive_regulation RELA TLR7 15330257 1287698 Upon stimulation , recruits a cytoplasmic adaptor molecule MyD88 , then IL-IR associated kinase (IRAK) , and finally *induces* activation of [NF-kappaB] and MAP kinases . Positive_regulation RELA TLR7 16008344 1431358 Additionally , *dependent* [NF-kappaB] translocation in astrocytes appears to be blocked by gelsolin . Positive_regulation RELA TLR7 16052631 1442021 Cytosolic components of NADPH oxidase suppressed mediated [NF-kappaB] *activation* as well as IFN-beta promoter activation . Positive_regulation RELA TLR7 16244651 1476904 Furthermore , epithelial cell-surface hyaluronan was protective against apoptosis , in part , through dependent basal *activation* of [NF-kappaB] . Positive_regulation RELA TLR7 16325814 1490974 gAd mediated inhibition of *mediated* IkappaB phosphorylation and [NF-kappaB] activation was eliminated by the pretreatment of cycloheximide . Positive_regulation RELA TLR7 16457754 1522437 The activation *induce* the [NF-kappaB] translocation to the nucleus and cytokine secretion . Positive_regulation RELA TLR7 16643855 1557059 Overexpression and knockdown by siRNA indicated that ZCCHC11 functions as a negative regulator of mediated [NF-kappaB] *activation* . Positive_regulation RELA TLR7 16757890 1571945 These observations suggest that immediate response of NODs to endotoxins could result from [NF-kappaB] *activation* via signaling , whereas the second rise in NOD mRNAs might have resulted from TNF-alpha production possibly through NF-kappaB , TLR , and/or NOD signalings . Positive_regulation RELA TLR7 16894359 1601069 Lung epithelial cell overexpression of high molecular mass HA protected mice against acute lung injury and apoptosis , in part through *dependent* basal activation of [NF-kappaB] . Positive_regulation RELA TLR7 16930560 1627230 In this review we will summarize the current knowledge of mediated [NFkappaB] *activation* , and also the recent discoveries that subtle differences in kappaB binding sequences and NFkappaB dimer formation result in specific gene expression profiles . Positive_regulation RELA TLR7 17100624 1644741 In the intestine , *dependent* activation of [NF-kappaB] plays a vital role in maintaining epithelial homeostasis as well as regulating infections and inflammation , while dysregulation of TLR signaling is associated with the pathogenesis of inflammatory bowel diseases (IBD) . Positive_regulation RELA TLR7 17349209 1708016 Many of the key molecular events required for *induced* [NF-kappaB] activation have been elucidated . Positive_regulation RELA TLR7 17462920 1743260 We demonstrated that pathogens trigger DC-SIGN on human DCs to activate the serine and threonine kinase Raf-1 , which subsequently leads to acetylation of the NF-kappaB subunit p65 , but only after induced *activation* of [NF-kappaB] . Positive_regulation RELA TLR7 17475882 1738506 We conclude that bacteria induced experimental colitis involves the activation of *induced* [NF-kappaB] signaling derived mostly from mucosal immune cells . Positive_regulation RELA TLR7 17475882 1738526 Blocking *induced* [NF-kappaB] activity may represent an attractive strategy to treat immune mediated intestinal inflammation . Positive_regulation RELA TLR7 17724128 1789800 Microarray analysis showed that Trib1-deficient macrophages exhibited a dysregulated expression pattern of lipopolysaccharide-inducible genes , whereas mediated *activation* of MAP kinases and [NF-kappaB] was normal . Positive_regulation RELA TLR7 17785851 1790802 IL-1R associated kinase (IRAK)-1 is a critical mediator of *induced* activation of the transcription factor [NF-kappaB] . Positive_regulation RELA TLR7 18025224 1827722 Using gene knockout mice and siRNA to silence mouse genes , we showed that both TLR2 and are *essential* for the induction of [NFkappaB] containing genes and NFkappaB-IFN-sensitive response element ( ISRE ) cocontaining genes by either P. gingivalis or its purified components . Positive_regulation RELA TLR7 18079163 1874554 IRAK-4 dependent degradation of IRAK-1 is a negative feedback signal for mediated [NF-kappaB] *activation* . Positive_regulation RELA TLR7 18079163 1874586 the autophosphorylation of IRAK-1 is not necessary to terminate the *induced* activation of [NF-kappaB] . Positive_regulation RELA TLR7 18345001 1886600 TRIM30 alpha negatively regulates mediated [NF-kappa B] *activation* by targeting TAB2 and TAB3 for degradation . Positive_regulation RELA TLR7 18345001 1886637 TRIM30alpha promoted the degradation of TAB2 and TAB3 and inhibited [NF-kappaB] activation *induced* by signaling . Positive_regulation RELA TLR7 18345001 1886659 Our results collectively indicate that TRIM30alpha negatively regulates mediated [NF-kappaB] *activation* by targeting degradation of TAB2 and TAB3 by a ` feedback ' mechanism . Positive_regulation RELA TLR7 18347055 1898408 The sites of IRAK-1 ubiquitination were mapped to Lys134 and Lys180 , and arginine substitution of these residues impaired mediated IRAK-1 ubiquitination , NEMO binding , and [NF-kappaB] *activation* . Positive_regulation RELA TLR7 18617174 2019981 activation *results* in nuclear translocation of the transcription factor [Nuclear Factor-kappa B (NF-kappaB)] that controls the transcription of many inflammatory genes . Positive_regulation RELA TLR7 18644884 1960211 Taken together , our results demonstrate that Campylobacter induced IL-8 secretion requires functional flagella and CDT and depends on the *activation* of [NF-kappaB] through signaling and CDT in human intestinal epithelial cells . Positive_regulation RELA TLR7 18794297 1986477 Two parallel interleukin-1 (IL-1) mediated signaling pathways have been uncovered for mediated [NFkappaB] *activation* : TAK1 dependent and MEKK3 dependent pathways , respectively . Positive_regulation RELA TLR7 18794297 1986503 Deletion analysis of IRAK4 indicates the essential structural role of the IRAK4 death domain in receptor proximal signaling for mediating induced [NFkappaB] *activation* . Positive_regulation RELA TLR7 19043549 1998927 This enhanced response involved [NF-kappaB] *activation* by signaling as well as Nod1 and Nod2 detection of type IV secretion . Positive_regulation RELA TLR7 19393720 2082072 At the molecular level , beta-glucan suppressed mediated [NF-kappaB] *activation* , which may be responsible for the diminished capacity of microglia to produce cytokines in response to TLR stimulation . Positive_regulation RELA TLR7 19439083 2090464 *Activation* of the transcription factor [NFkappaB] through following bacterial infection is principally involved in regulating lung inflammation in CF . NFkappaB regulates the transcription of several genes that are involved in inflammation , anti-apoptosis and anti-microbial activity , and hyper-activation of this transcription factor leads to a potent inflammatory response . Positive_regulation RELA TLR7 19494276 2091533 Reporter analyses demonstrated that mediated [NF-kappaB] *activation* was higher in Trim21 ( -/- ) cells than in wild-type cells , most likely accounting for their enhanced cytokine expression . Positive_regulation RELA TLR7 19521662 2108920 Transforming growth factor-beta activated kinase 1 ( TAK1 ) is a serine/threonine protein kinase that is critically involved in the *activation* of [NF-kappaB] by tumor necrosis factor ( TNFalpha ) , interleukin-1beta (IL-1beta) and ligands . Positive_regulation RELA TLR7 19679103 2132903 Importantly , the TLR3 ligand , as well as other ligands , significantly *promoted* the expression of proinflammatory cytokines and the activation of [NF-kappaB] by LRRC19 . Positive_regulation RELA TLR7 19719951 2133683 [Nuclear factor-kappa B (NF-kappaB)] regulates many genes essential for inflammation and immunity and is *activated* by . Positive_regulation RELA TLR7 19796680 2183899 These same ligand *induced* [NFkappaB] responses are not observed in TLR deficient HEK293 cells , but are re-established in HEK293 cells stably transfected with TLR4/MD2 , and are significantly inhibited by alpha-2,3-sialyl specific Maackia amurensis ( MAL-2 ) lectin , alpha-2,3-sialyl specific galectin-1 and neuraminidase inhibitor Tamiflu but not by alpha-2,6-sialyl specific Sambucus nigra lectin ( SNA ) . Positive_regulation RELA TLR7 19913487 2166503 Both proteins interact with IRAK2 and TRAF6 and suppress *dependent* [NF-kappaB] activation . Positive_regulation RELA TLR7 19933851 2172029 Specifically , we demonstrate the Siglec-E expression inhibits *induced* [NF-kappaB] and more importantly , the induction of the antiviral cytokines IFN-beta and RANTES . Positive_regulation RELA TLR7 20308556 2238094 Using HEK293 cells transfected with murine TLR7 or TLR8 and a NF-kappaB luciferase reporter , we demonstrated that stimulation of TLR8- , but not , transfected cells with either VV or VV DNA *resulted* in substantial [NF-kappaB] activation , and that siRNA mediated knockdown of TLR8 expression in pDCs led to a complete ablation of VV-induced type I IFN production . Positive_regulation RELA TLR7 20385024 2261942 Also , the suppressive effect of triptolide on *induced* [NFkappaB] activation was observed when either MyD88 or TRIF was knocked out , confirming that both MyD88 and TRIF mediated NFkappaB activation may be inhibited by triptolide . Positive_regulation RELA TLR7 20584979 2303315 These experiments reveal a novel PDK-1 dependent negative feedback inhibition of *induced* [NF-kappaB] activation in macrophages in vivo . Positive_regulation RELA TLR7 20702732 2312687 We present a functional analysis of zebrafish Myd88 and Tirap and suggest that Myd88 is more important than Tirap for the activation of *mediated* [NF-kappaB] , which may be a novel mechanism of Myd88 dependent TLR signaling in teleosts . Positive_regulation RELA TLR7 20816209 2314909 Notably , DC-SIGN triggering by these pathogens results in a specific Raf-1 dependent signaling pathway that modulates induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 10022904 590578 Previous studies have demonstrated that the atypical PKCs are stimulated by and are *required* for the activation of [NF-kappaB] by this cytokine through a mechanism that most probably involves the phosphorylation of IkappaB . Positive_regulation RELA TNF 10029619 591694 *stimulated* [NF-kappaB] activation and nuclear translocation and the degradation of Ikappa-Balpha were blocked by mesalamine . Positive_regulation RELA TNF 10037458 592126 The PKC inhibitor calphostin C inhibited [NF-kappaB] *activation* by or interleukin (IL)-1beta in Jurkat or NIH3T3 cells but not in MCF7 A/Z cells . Positive_regulation RELA TNF 10063910 593330 induced *activation* of [NF-kappaB] activity was suppressed by NAC , and H2O2 caused significant activation of NF-kappaB . Positive_regulation RELA TNF 10072079 594383 Conversely , expression of kinase-deficient Cot inhibits CD3/CD28 but not *induction* of [NF-kappaB] . Positive_regulation RELA TNF 10075662 594899 Activation of [NF-kappaB] by RANK *requires* receptor associated factor ( TRAF) 6 and NF-kappaB inducing kinase . Positive_regulation RELA TNF 10079106 595531 Specific inhibitors of p38alpha MAPk blocked LPS induced adhesion , [nuclear factor-kappa B (NF-kappaB)] *activation* , and synthesis of . Positive_regulation RELA TNF 10082424 597721 induces apoptosis in confluent LLC-PK1 epithelial cells , but also *activates* [NF-kappaB] , a negative regulator of apoptosis . Positive_regulation RELA TNF 10085086 599328 *induces* Bcl-2 and Bcl-x expression through [NFkappaB] activation in primary hippocampal neurons . Positive_regulation RELA TNF 10089130 599979 Phospholipase A2 inhibitors and leukotriene synthesis inhibitors block *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 10089130 599982 The role , however , of AA and its metabolites in induced [NF-kappaB] *activation* is still obscure . Positive_regulation RELA TNF 10092612 600597 Unlike lipopolysaccharide , C2-ceramide failed to activate [NF-kappaB] and did not *induce* production of or interleukin-6 . Positive_regulation RELA TNF 10102704 602367 The augmented *induced* [NF-kappaB] activation in HG was associated with increased TNF-alpha mediated transcriptional activation of the vascular cell adhesion molecule-1 promoter . Positive_regulation RELA TNF 10187765 602513 Tumor necrosis factor alpha (TNFalpha) also stimulated increased PI 3-kinase activity , however *stimulated* [NF-kappaB] activation was not affected by the PI 3-kinase inhibitors or the p85 dominant negative mutant . Positive_regulation RELA TNF 10187861 603063 Furthermore , tumor necrosis factor-alpha activated endogenous TAK1 , and the kinase negative TAK1 acted as a dominant negative inhibitor against *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 10192291 603646 These DOTMA/DOPE induced changes were not due to alterations in VCAM-1 mRNA stability , nor did DOTMA/DOPE inhibit *induced* [NF-kappaB-like] binding activity in nuclear extracts of HPAEC , as analyzed by electrophoretic mobility shift assay . Positive_regulation RELA TNF 10195895 604156 In contrast , there was no impairment of [NF-kappaB] activation *induced* by either interleukin-1 or in IKKalpha-deficient embryonic fibroblasts and thymocytes , indicating that IKKalpha is not essential for cytokine induced activation of NF-kappaB . Positive_regulation RELA TNF 10195897 604191 Mouse embryonic fibroblast cells that were isolated from IKK2-/- embryos showed a marked reduction in tumor necrosis factor-alpha (TNF-alpha)- and interleukin-1alpha induced [NF-kappaB] activity and an enhanced apoptosis in *response* to . Positive_regulation RELA TNF 10196356 604661 Previous studies in airway epithelial cells demonstrated that induced [NF-kappaB] *activation* is transient due to regulation by IkappaBalpha . Positive_regulation RELA TNF 10196356 604667 Thus , while manipulation of IkappaBalpha results in reversal of induced [NF-kappaB] *activation* , manipulation of IkappaBalpha does not result in a reversal of RSV induced NF-kappaB activation . Positive_regulation RELA TNF 10199558 605270 NaS decreased *stimulated* [NFkappaB] activation by 50 % as assessed by EMSA . Positive_regulation RELA TNF 10199816 605361 These effects of lactacystin and PS-341 were associated with inhibitory effects on *stimulated* [NF-kappaB] activation in both HUVEC and ECV . Positive_regulation RELA TNF 10199816 605363 Our results demonstrate the importance of the 26S proteasome in induced *activation* of [NF-kappaB] , ECAM expression , and leukocyte-endothelial adhesive interactions in vitro . Positive_regulation RELA TNF 10201927 605681 Our observations support the notion that full LPS response of gene *requires* both [NF-kappaB] and non-NF-kappaB nuclear proteins . Positive_regulation RELA TNF 10201951 605704 These data suggest that in fibroblasts activates and *initiates* the nuclear translocation of [NF-kappa B] that binds a divergent NF-kappa B element and plays a critical role in the observed inhibition of alpha 2 ( I ) collagen gene transcription . Positive_regulation RELA TNF 10201981 605769 We characterized the effect of a dominant negative TRAF-2 delivered by an adenoviral vector ( Ad5dnTRAF-2 ) on the cytokine signaling cascade in several IEC and also investigated whether inhibiting the TRAF-2 transmitting signal blocked *induced* [NF-kappa B] and IL-8 gene expression . Positive_regulation RELA TNF 10210266 607491 In the present study , [NF-kappaB] was *activated* by in rat aortic smooth muscle cells as demonstrated by electrophoretic mobility shift assay . Positive_regulation RELA TNF 10210266 607496 The activity of [NF-kappaB] *induced* by was blocked by calpain inhibitor I , a potent NF-kappaB inhibitor . Positive_regulation RELA TNF 10218970 608580 Both IL-1beta and *activated* [nuclear factor (NF)-kappaB] as demonstrated by electrophoretic mobility shift assay . Positive_regulation RELA TNF 10222332 609620 Under these conditions , *induced* [NF-kappaB] nuclear translocation and DNA binding were inhibited , NF-kappaB dependent luciferase activity was reduced by 50 % , there was no degradation of native IkappaBalpha detected , interleukin-6 production was reduced by 54 % , and VSMC proliferation was decreased by 60 % . Positive_regulation RELA TNF 10224110 609994 PG490 potently inhibited induced *activation* of [NF-kappaB] . Positive_regulation RELA TNF 10224110 609998 Our identification of a compound that blocks *induced* activation of [NF-kappaB] may enhance the cytotoxicity of TNF-alpha on tumors in vivo and limit its proinflammatory effects . Positive_regulation RELA TNF 10226064 610330 In contrast , *activated* [NF-kappaB] in a Ras independent fashion . Positive_regulation RELA TNF 10226064 610332 Evaluation of members of the mitogen activated protein kinase (MAPK) family as downstream effectors of Ras revealed the requirement of MAPK/ extracellular regulated kinase (ERK) kinase kinase ( MEKK)1 and c-Jun N-terminal kinases in the *induction* of [NF-kappaB] by both oxidants and , whereas the MEK-ERK pathway negatively regulates NF-kappaB . Positive_regulation RELA TNF 10232679 611404 Treatment with N ( G ) -nitro-L-arginine methyl ester ( L-NAME ) did not affect initial *activation* of [NF-kappaB] by , but unveiled an inhibitory effect of NO generation on NF-kappaB activity after 4 h . Positive_regulation RELA TNF 10318796 611881 Pretreating Mo7e cells with SN50 blocked *induced* nuclear translocation of [NF-kappaB] and inhibited TNF-alpha induced Mo7e cell survival and proliferation . Positive_regulation RELA TNF 10336463 615454 Similarly , RAI inhibited the endogenous [NF-kappaB] activity *induced* by . Positive_regulation RELA TNF 10340762 616211 We studied the kinetics of [NF-kappaB] *induction* by in primary astrocytes , and in the neuroblastoma cell line Neuro2A , and compared it to fibroblasts . Positive_regulation RELA TNF 10342828 616512 Treatment of the cells with 17beta-E2 partially suppressed the *activation* of [NF-kappaB] by , but did not block cytokine induced IL-6 secretion . Positive_regulation RELA TNF 10346820 616691 [NF-kappaB] activation *mediated* by and IL-1 is diminished in IKK1-deficient mouse embryonic fibroblast (MEF) cells . Positive_regulation RELA TNF 10361130 619766 This contrasts with dependent [NF-kappaB] *activation* , which occurs earlier , involves p65/p50 dimers , and is dependent on IkappaB degradation . Positive_regulation RELA TNF 10364242 620526 Expression of the CARD domain of human CLAP abrogates induced [NF-kappaB] *activation* , suggesting that cellular CLAP plays an essential role in this pathway of NF-kappaB activation . Positive_regulation RELA TNF 10364831 621106 Here we show that micromolar concentrations of hypericin inhibited the PMA- and induced *activation* of [NF-kappa B] in HeLa and TC10 cells , respectively . Positive_regulation RELA TNF 10376811 623514 However , PDTC did not inhibit *induced* [NF-kappaB] DNA binding activity but potentiated the effect of TNF-alpha on kappaB dependent gene expression . Positive_regulation RELA TNF 10383449 624584 The human tumor necrosis factor (TNF) receptor associated factor 1 gene ( TRAF1 ) is up-regulated by cytokines of the TNF ligand family and modulates induced *activation* of [NF-kappaB] and c-Jun N-terminal kinase . Positive_regulation RELA TNF 10383449 624598 In fact , we found that TNF induced activation of JNK is prolonged in transfectants overexpressing TRAF1 , whereas overexpression of a deletion mutant of TRAF1 in which the N-terminal part had been replaced by the green fluorescent protein interfered with induced *activation* of [NF-kappaB] and JNK . Positive_regulation RELA TNF 10385418 625465 *induced* [NF-kappaB] activation in both primary islet cells and NIT-1 cells . Positive_regulation RELA TNF 10385526 625572 We show that A20 does not inhibit *induced* nuclear translocation and DNA binding of [NF-kappaB] , although it completely prevents the TNF- induced activation of an NF-kappaB dependent reporter gene , as well as TNF induced IL-6 and granulocyte macrophage-colony stimulating factor gene expression . Positive_regulation RELA TNF 10385526 625576 Moreover , [NF-kappaB] activation *induced* by overexpression of the receptor associated proteins TNF receptor associated death domain protein ( TRADD ) , receptor interacting protein ( RIP ) , and TNF recep- tor associated factor 2 ( TRAF2 ) was also inhibited by expression of A20 , whereas NF-kappaB activation induced by overexpression of NF-kappaB inducing kinase (NIK) or the human T cell leukemia virus type 1 ( HTLV-1 ) Tax was unaffected . Positive_regulation RELA TNF 10391885 626762 IkappaBalphaM was resistant to stimulus dependent degradation and suppressed [NF-kappaB] activation *induced* by ( 10 ng/ml ) or IL-1beta ( 10 ng/ml ) . Positive_regulation RELA TNF 10391896 626783 [NF-kappaB] *activation* by provides a survival signal that impairs the TNFalpha induced apoptotic response . Positive_regulation RELA TNF 10391896 626787 In addition , the down-regulation of Par-4 levels by oncogenic Ras sensitizes cells to induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 10404391 629265 Several lines of evidence suggest that *activates* transcription factor [nuclear factor-kappa B (NF kappa B)] through activation of protein kinase C ( PKC ) or the hydrolysis of sphingomyelin to ceramide in a number of cell types . Positive_regulation RELA TNF 10409708 630330 The p75 neurotrophin receptor (p75NTR) alters mediated NF-kappaB activity under physiological conditions , but direct p75NTR mediated [NF-kappaB] activation *requires* cell stress . Positive_regulation RELA TNF 10409708 630335 All cell types showed mediated *activation* of [NF-kappaB] , but direct neurotrophin dependent activation of NF-kappaB was never observed under normal growth conditions . Positive_regulation RELA TNF 10409708 630344 Although NGF binding did not directly activate NF-kappaB under normal conditions , NGF consistently altered *dependent* [NF-kappaB] activation in each cell type examined , and extended exposure to NGF and TNF always increased NF-kappaB activation over that achieved with TNF alone . Positive_regulation RELA TNF 10414954 631098 receptor activation *results* in activation of the transcription factor [nuclear factor kappaB (NF-kappaB)] , which may serve an antiapoptotic role via the induction of target genes manganese superoxide dismutase ( MnSOD ) and/or calbindin . Positive_regulation RELA TNF 10416616 631443 *Induction* of [NF-kappaB] by was inhibited by the addition of protease inhibitors calpain inhibitor I and N-tosyl-phechloromethyl ketone and antioxidant 1-pyrrolidinecarbodithioic acid , whereas constitutive activation of NF-kappaB and cytokine KC mRNA expression was inhibited by N-tosyl-phechloromethyl ketone alone . Positive_regulation RELA TNF 10416616 631445 Overexpression of a human Ikappa(B)alpha dominant suppresser in Pam 212 cells inhibited *induced* [NF-kappaB] binding activity and KC expression . Positive_regulation RELA TNF 10416616 631447 These data indicate that activation of NF-kappaB contributes to increased expression of proinflammatory cytokines during metastatic tumor progression of squamous cell carcinoma , and that distinct mechanisms may be involved in the regulation of constitutive and induced *activation* of [NF-kappaB] in squamous cell carcinoma . Positive_regulation RELA TNF 10416957 631453 In addition , it has been established that can *activate* the expression of wild type p53 in concert with the nuclear transcription factor , [NF-kappa B] . Positive_regulation RELA TNF 10419449 631726 Since activation of nuclear factor kappaB (NF-kappaB) has been shown to play an anti-apoptotic role in TNF induced apoptosis , we examined apoptotic susceptibility and [NF-kappaB] activation *induced* by in the E1A transfectants and their parental cells . Positive_regulation RELA TNF 10428782 633244 Cell stress and MKK6b mediated p38 MAP kinase activation inhibit *induced* IkappaB phosphorylation and [NF-kappaB] activation . Positive_regulation RELA TNF 10428782 633280 Thus , sustained p38 activation by various stimuli inhibits *induced* IkappaB phosphorylation and [NF-kappaB] activation . Positive_regulation RELA TNF 10430178 633569 IL-1beta and *stimulated* nuclear [NF-kappaB] levels by about fourfold and fivefold , respectively , in HASMCs . Positive_regulation RELA TNF 10438843 635060 is the major *inducer* of [NF-kappaB] and particularly of the p50-p65 complex , whereas IL-7 acts as a cofactor by sustaining the expression of the p75 TNF receptor . Positive_regulation RELA TNF 10438953 635172 Using EMSA , we show that stimulation with or IL-1 beta *induces* [NF-kappa B] DNA binding activity in human airway smooth muscle cells . Positive_regulation RELA TNF 10438953 635179 In cells transfected with the luciferase reporter , dexamethasone did not affect *induced* [NF-kappa B-dependent] transcription . Positive_regulation RELA TNF 10439045 635223 Transfection of cells with gamma-GCS cDNA blocked induced [NF-kappa B] *activation* , cytoplasmic I kappa B alpha degradation , nuclear translocation of p65 , and NF-kappa B-dependent gene transcription . Positive_regulation RELA TNF 10440583 635389 The role of superoxide radical in *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 10440583 635399 02*- seems to play a key role in induced [NF-kappaB] *activation* in macrophages . Positive_regulation RELA TNF 10440583 635401 Xanthine and xanthine oxidase appears to be a source of O2*- radicals responsible for *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 10447681 636982 Pervanadate induced tyrosine phosphorylation increased the *induced* cytotoxicity and [NF-kappaB] activation , suggesting that it stimulates early signaling events prior to the separation of the two signaling pathways . Positive_regulation RELA TNF 10449775 637413 *Activation* of either [NF-kappaB] or c-Jun NH ( 2 ) -terminal kinase/stress activated protein kinase by , CD27 , and CD40 was not abrogated in traf5 ( -/- ) mice . Positive_regulation RELA TNF 10455154 638575 We also found that induced *activation* of [NF-kappaB] did not account for the enhanced TNF susceptibility by E6 . Positive_regulation RELA TNF 10477576 643049 rapidly *induced* marked activation of nuclear transcription factor [NF-kappa B] in all 4 cell lines . Positive_regulation RELA TNF 10477716 643260 treatment *induces* a rapid translocation of the 65 kD transcriptional activator [NF-kappaB] subunit , Rel A , whose binding in the nucleus occurs before changes in intracellular ROS . Positive_regulation RELA TNF 10484327 643966 Quercetin had no effect on PMA- or *induced* [nuclear factor-kappaB (NF-kappaB)] activation . Positive_regulation RELA TNF 10485710 644441 Here we show that the Akt serine-threonine kinase is involved in the *activation* of [NF-kappaB] by . Positive_regulation RELA TNF 10485710 644513 Wortmannin ( a PI(3)K inhibitor ) , dominant negative PI(3)K or kinase-dead Akt inhibits mediated [NF-kappaB] *activation* . Positive_regulation RELA TNF 10485710 644549 Mutation of this amino acid blocks phosphorylation by Akt or and *activation* of [NF-kappaB] . Positive_regulation RELA TNF 10490923 645815 [NF-kappaB] activation in *response* to , IL-1beta , phorbol ester , and H ( 2 ) O ( 2 ) was down-regulated by polaprezinc . Positive_regulation RELA TNF 10490994 645860 The factor had no effect on TNF induced cytotoxicity , but abrogated induced [NF-kappa B] *activation* . Positive_regulation RELA TNF 10524940 653865 In normal human urothelial cells , activation of the [NF-kappaB] complex in *response* to stimulation with , LPS , and dsRNA was detected by immunohistochemical methods and EMSA . Positive_regulation RELA TNF 10532402 562328 Involvement of reactive oxygen species in *mediated* activation of the transcription factor [NF-kappaB] in canine dermal fibroblasts . Positive_regulation RELA TNF 10532402 562330 With respect to a possible therapeutic modulation of *mediated* activation of [Nuclear Factor-kappa B (NF-kappaB)] in canine cutaneous inflammation , we investigated the role of NF-kappaB and the involvement of reactive oxygen species ( ROS ) in the TNF-alpha signalling pathway in dermal fibroblasts of the dog . Positive_regulation RELA TNF 10540155 563254 The EMSAs indicated that sodium butyrate suppressed *induced* [nuclear factor (NF)-kappaB-] and activation protein (AP)-1-DNA binding activity , but enhanced TNF-alpha induced activation of CCAAT/enhancer binding protein ( C/EBP)beta (NF-IL-6 ) -DNA binding activity . Positive_regulation RELA TNF 10541434 563492 Fibrosis is frequently associated with inflammation , which is accompanied by increased levels of and *activation* of the transcription factor [NF-kappaB] . Positive_regulation RELA TNF 10544244 564087 Interestingly , overexpression of TRAF1 in HEK293T completely prevented [NF-kappaB] activation *induced* by , IL-1 , or overexpression of TRAF2 or TRAF6 . Positive_regulation RELA TNF 10544256 564102 Using electrophoretic mobility shift assays , we found that not only but also interleukin-1beta and parathyroid hormone (PTH) *caused* dose and time related increases in [nuclear factor kappaB (NF-kappaB)-DNA] binding in Saos-2 human osteoblastic ( hOB ) cells . Positive_regulation RELA TNF 10544256 564108 *Activation* of [NF-kappaB] by was reproduced in primary hOBs . Positive_regulation RELA TNF 10559511 566624 Angiotensin II (Ang II) and *increased* [NF-kappaB] activity in VSMC ( 2 and 5-fold , respectively ) . Positive_regulation RELA TNF 10564241 567199 These results suggest that *contributes* , in part , to changes in interstitial volume , myofibroblast differentiation , and [NF-kappaB] activation in the kidney during ureteral obstruction . Positive_regulation RELA TNF 10567330 567624 In contrast , induced [NF-kappaB] *activation* occurred in concert with degradation of IkappaBalpha . Positive_regulation RELA TNF 10567330 567627 Inhibition of IkappaBalpha degradation with a proteasome inhibitor , MG-115 , blocked [NF-kappaB] activation *induced* by ; Positive_regulation RELA TNF 10580148 570010 Overexpression of AZ2 inhibited *mediated* [NFkappaB] activation . Positive_regulation RELA TNF 10580567 570096 RPMI-8226 cells showed [NF-kappaB] *activation* by , but contrary to OH-2 , not by CH11 . Positive_regulation RELA TNF 10581242 570230 We find can *activate* the nuclear [IkappaBalpha-NF-kappaB] complexes by the classical mechanism of proteasome mediated degradation of IkappaBalpha . Positive_regulation RELA TNF 10585438 571395 Stimulation of Sertoli cells with , an NF-kappaB activating cytokine produced by round spermatids located adjacent to Sertoli cells , *stimulated* the elimination of IkappaB , the translocation of additional NF-kappaB to the nucleus , and increased [NF-kappaB] binding to CREB promoter kappaB enhancer elements . Positive_regulation RELA TNF 10586080 571795 Silymarin suppresses induced *activation* of [NF-kappa B] , c-Jun N-terminal kinase , and apoptosis . Positive_regulation RELA TNF 10586080 571797 Silymarin blocked induced *activation* of [NF-kappa B] in a dose- and time dependent manner . Positive_regulation RELA TNF 10593965 572902 *stimulated* [nuclear factor (NF) kappaB] activation plays a key role in the pathogenesis of inflammatory bowel disease (IBD) . Positive_regulation RELA TNF 10604572 575045 GalN treatment failed to affect induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 10615065 656334 however , *induced* both AP-1 and [NF-kappaB] binding activities in BET-1A cells . Positive_regulation RELA TNF 10619864 657393 However , [NF-kappaB] activation and IL-8 secretion *induced* by S. typhimurium , but not by , was preceded by and required an increase in intracellular [ Ca ( 2+ ) ] . Positive_regulation RELA TNF 10623427 576188 IL-8 and LIF had no effect on the induced [NF-kappaB] *accumulation* , while IL-11 significantly decreased it ( P < 0. 02 ) . Positive_regulation RELA TNF 10623598 658135 TGF-beta induced matrix proteins inhibit p42/44 MAPK and JNK activation and suppress *mediated* IkappaBalpha degradation and [NF-kappaB] nuclear translocation in L929 fibroblasts . Positive_regulation RELA TNF 10625622 658570 In contrast , although *activated* [NF-kappaB] transcription , E5510 had no effect on TNF-alpha induced activation . Positive_regulation RELA TNF 10625622 658591 NF-kappaB was activated after the stimulation of TRAP , bFGF , and TNF-alpha in electrophoretic mobility shift assay , and E5510 suppressed the [NF-kappaB] activation induced by TRAP and bFGF but not the *activation* by . Positive_regulation RELA TNF 10640750 660642 Phosphatidylinositol 3-kinase as a mediator of induced [NF-kappa B] *activation* . Positive_regulation RELA TNF 10640750 660646 The *activation* of transcription factor [NF-kappa B] by involves the stimulation of a novel signaling cascade . Positive_regulation RELA TNF 10640750 660648 In this paper we show that phosphatidylinositol 3-kinase ( PI 3-kinase ) may play a pivotal role in mediated *activation* of [NF-kappa B-dependent] genes . Positive_regulation RELA TNF 10640750 660655 A dominant negative mutant of the p85 regulatory subunit of PI 3-kinase , which is a potent inhibitor of PI 3-kinase signaling , effectively blocked the *induced* expression of an [NF-kappa B-dependent] reporter gene . Positive_regulation RELA TNF 10644576 661111 Human hepatoma cell lines were used to investigate the effectiveness and specificity of the fungal metabolite gliotoxin in inhibiting induced [NF-kappaB] *activation* in transformed cells . Positive_regulation RELA TNF 10644980 661664 Induction of p21Waf1/Cip1 by *requires* [NF-kappaB] activity and antagonizes apoptosis in Ewing tumor cells . Positive_regulation RELA TNF 10644980 661670 Our results therefore identify p21Waf1/Cip1 as a mediator of the antiapoptotic effect of *induced* [NF-kappaB] in Ewing tumor cells . Positive_regulation RELA TNF 10671572 667273 Both DNA binding assays and luciferase assays revealed that induced [NF-kappaB] *activation* is defective in T2 cells . Positive_regulation RELA TNF 10677219 668080 On the other hand , is a strong *activator* of [NF-kappa B] whereas sorbitol is not . Positive_regulation RELA TNF 10692572 671230 The C-terminal cleavage product blocks the *induction* of [NF-kappaB] by and therefore functions as a dominant negative ( DN ) form of TRAF1 . Positive_regulation RELA TNF 10692573 671232 We show that the serine/threonine kinase RIP that is required for induced [NF-kappaB] *activation* is processed by caspase-8 into a dominant negative ( DN ) fragment during death receptor induced apoptosis , thereby leading to a blockade of NF-kappaB mediated anti-apoptotic signals . Positive_regulation RELA TNF 10700573 672419 Sodium valproate inhibits production of and IL-6 and *activation* of [NF-kappaB] . Positive_regulation RELA TNF 10704251 672817 Pretreatment with either compound inhibited TNF-alpha mediated activation of the IL-8 promoter and *mediated* nuclear translocation of [NF-kappaB] . Positive_regulation RELA TNF 10707928 673459 In PANC-1 cells , IL-1beta and *induced* a rapid activation of [nuclear factor (NF)-kappaB] , and TGF-beta1 enhanced this activation slightly . Positive_regulation RELA TNF 10725745 677659 Phosphorylation of p42 and p44 MAPKs , which can be prevented by a mitogen activated protein/extracellular signal related kinase kinase-1 inhibitor , peaks by 15-20 min and largely disappears by 40 min . IL-11 does not activate NF-kappaB nor does it inhibit [NF-kappaB] *activation* by . Positive_regulation RELA TNF 10727667 678082 High glucose or mannitol also enhanced *stimulated* [NF-kappaB] activity . Positive_regulation RELA TNF 10727667 678084 An antioxidant N-acetyl-L-cysteine and a selective protein kinase C ( PKC ) inhibitor GF109203X significantly suppressed the induced [NF-kappaB] *activation* , and abrogated potentiation of TNFalpha induced NF-kappaB activity caused by high glucose ( 27.5 mmol/l ) . Positive_regulation RELA TNF 10728675 678159 In the progenitor B lymphocyte model FL5.12 , whereas [NF-kappaB] has an antiapoptotic function in *response* to , cytokine withdrawal causes nuclear translocation of NF-kappaB/cRel , where it is apoptogenic . Positive_regulation RELA TNF 10744037 680583 By immunocytochemical and functional assays , we found that SC expressed TNF receptors and that *promoted* in SC cultures transient activation of transcription factors [NFkappaB] and c-jun in the absence of apoptosis . Positive_regulation RELA TNF 10744638 680629 Here we demonstrate that cationic liposomes containing phosphorothioated oligodeoxynucleotides ( ODN ) with the kappaB binding site serving as competitive binding decoy , can prevent *induced* [NFkappaB] activity in endothelial cells in vitro . Positive_regulation RELA TNF 10744744 680745 The death domain kinase , receptor interacting protein ( RIP ) , is one of the major components of the tumor necrosis factor receptor 1 (TNFR1) complex and plays an essential role in mediated [nuclear factor kappaB (NF-kappaB)] *activation* . Positive_regulation RELA TNF 10744744 680752 These data indicate that Hsp90 plays an important role in mediated [NF-kappaB] *activation* by modulating the stability and solubility of RIP . Positive_regulation RELA TNF 10753878 682312 A mutant of Casper and the caspase-specific inhibitors crmA and BD-fmk partially inhibit TNF-R1- , TRADD , and *induced* [NF-kappaB] activation , suggesting that FADD , Casper , and caspase-8 function downstream of TRADD and contribute to TNF-R1 induced NF-kappaB activation . Positive_regulation RELA TNF 10754482 682703 The binding activity of AP-1 was found to be stimulated by the growth inhibitory cytokines , TGF-beta1 and TNF-alpha , and the binding of [NF-kappaB] was *stimulated* by . Positive_regulation RELA TNF 10755617 682784 The adapter protein RIP plays a crucial role in [NF-kappaB] *activation* by . Positive_regulation RELA TNF 10759715 683218 Forskolin inactivated NF-kappaB in K/Dau600 cells but not in K562 cl. 6 cells , whereas *activated* [NF-kappaB] in K562 cl.6 cells but not in K/Dau600 cells . Positive_regulation RELA TNF 10759767 683488 To examine the effects of AF and GSTM on induced [NF-kappaB] *activation* this was measured in HUVEC nuclear extracts by an electrophoretic mobility shift assay . Positive_regulation RELA TNF 10759767 683500 AF , but not GSTM , decreased induced [NF-kappaB] *activation* in HUVEC . Positive_regulation RELA TNF 10766741 684457 NEMO/IKKgamma-deficient primary murine embryonic fibroblasts ( MEFs ) lack detectable [NF-kappaB] DNA binding activity in *response* to , IL-1 , LPS , and Poly ( IC ) and do not show stimulus dependent IkappaB kinase activity , which correlates with a lack of phosphorylation and degradation of IkappaBalpha . Positive_regulation RELA TNF 10766844 684550 The Drosophila receptor associated factor-1 ( DTRAF1 ) interacts with Pelle and *regulates* [NFkappaB] activity . Positive_regulation RELA TNF 10779771 687505 Transduced Bcl-2 did not reduce mediated [NF-kappaB] *activation* or constitutive expression of class I MHC molecules . Positive_regulation RELA TNF 10784415 688251 induced *activation* of transcription factor [nuclear factor-kappaB (NF-kappaB)] was observed in all 3 cell lines . Positive_regulation RELA TNF 10784415 688253 Pretreatment with the known potent NF-kappaB inhibitor pyrolidine dithiocarbamate ( PDTC ) profoundly suppressed the activation of [NF-kappaB] *induced* by and potentiated TNF cytotoxicity in all 3 cell lines . Positive_regulation RELA TNF 10788437 688680 Treatment of the CaCOV3 human ovarian cell line with hCG blocked induced *activation* of [NF-kappaB] , IkappaBalpha degradation , and NF-kappaB dependent reporter gene transcription . Positive_regulation RELA TNF 10788610 688943 N-acetylcysteine suppresses *induced* [NF-kappaB] activation through inhibition of IkappaB kinases . Positive_regulation RELA TNF 10788610 688953 NAC also suppressed the *induced* activation of IKKalpha and IKKbeta , phosphorylation and degradation of IkappaB , and nuclear translocation of [NF-kappaB] . Positive_regulation RELA TNF 10795524 689671 Herpes simplex virus type 2 infection of macrophages impairs IL-4 mediated inhibition of NO production through induced *activation* of [NF-kappaB] . Positive_regulation RELA TNF 10795740 689759 To understand the mechanism by which RIP and TRAF2 regulate *induced* activation of the transcription factor [NF-kappaB] , we investigated their respective roles in TNF-R1 mediated IKK activation using both RIP-/- and TRAF2-/- fibroblasts . Positive_regulation RELA TNF 10799299 691081 PI3K and AKT cell survival signaling were correlated with increased *stimulated* [NF-kappaB] activity in MCF-7 cells . Positive_regulation RELA TNF 10799874 691386 These effects were specific to HIV-tat , as *activation* of [NF-kappa B] by PMA , LPS , H2O2 , and was minimally affected . Positive_regulation RELA TNF 10807663 692262 Nuclear [NF-kappaB] activity was robustly *induced* by . Positive_regulation RELA TNF 10815922 693559 p6R-IkappaB ( S32A + S36A ) blocked the *stimulation* of [NF-kappaB] activity by in prostate cancer cells . Positive_regulation RELA TNF 10820260 694370 Vesnarinone suppresses induced *activation* of [NF-kappa B] , c-Jun kinase , and apoptosis . Positive_regulation RELA TNF 10820260 694372 Vesnarinone blocked *induced* activation of [NF-kappa B] in a concentration- and time dependent manner . Positive_regulation RELA TNF 10820260 694376 The effects of vesnarinone were not cell type specific , as it blocked induced [NF-kappa B] *activation* in a variety of cells . Positive_regulation RELA TNF 10825233 696425 did not affect STAT1 activation , but *stimulated* DNA binding and transcriptional activity of [NF-kappaB] , both of which were further increased by IFN-gamma . Positive_regulation RELA TNF 10825233 696430 In conclusion , IFN-gamma activates STAT1 and potentiates induced [NF-kappaB] *activation* in INS-1 cells , thereby inducing iNOS and cell destruction . Positive_regulation RELA TNF 10839991 699643 *Activation* of endogenous [NF-kappaB] by was also able to inhibit the Smad7 promoter in human embryonic kidney 293 cells . Positive_regulation RELA TNF 10843709 700167 Resveratrol blocked induced *activation* of [NF-kappaB] in a dose- and time dependent manner . Positive_regulation RELA TNF 10843709 700170 Suppression of induced [NF-kappaB] *activation* by resveratrol was not restricted to myeloid cells ( U-937 ) ; Positive_regulation RELA TNF 10848577 701024 As a consequence , mediated I-kappaB degradation and [NF-kappaB] *activation* were markedly enhanced in Stat1-deficient cells , whereas overexpression of Stat1 in 293T cells blocked NF-kappaB activation by TNF-alpha . Positive_regulation RELA TNF 10849440 701175 TAF(II)105 , a substoichiometric coactivator subunit of TFIID , is important for activation of anti-apoptotic genes by [NF-kappaB] in *response* to the cytokine . Positive_regulation RELA TNF 10851266 701596 EMSAs indicated that trichostatin A weakly suppressed *induced* [NF-kappaB] and NF-IL6 activation . Positive_regulation RELA TNF 10853648 704105 DHM2EQ inhibited induced *activation* of [NF-kappaB] in human T cell leukemia cells , and also inhibited collagen induced arthritis in a rheumatoid model in mice . Positive_regulation RELA TNF 10866999 722320 An activator of peroxisome proliferator activated receptor gamma , 15-deoxy-Delta ( 12,14 ) -prostaglandin J ( 2 ) , also induces COX-2 expression and inhibits *induced* [NFkappaB] activation and COX-2 expression . Positive_regulation RELA TNF 10871845 708292 In the present report we show that anethole is a potent inhibitor of *induced* [NF-kappaB] activation ( an early response ) as monitored by electrophoretic mobility shift assay , IkappaBalpha phosphorylation and degradation , and NF-kappaB reporter gene expression . Positive_regulation RELA TNF 10878378 708970 These results indicate that mitochondrial ROS are required for the hypoxic activation of NF-kappa B and gene transcription , but not for the LPS *activation* of [NF-kappa B] . Positive_regulation RELA TNF 10881930 709233 IL-1beta and *induced* a rapid activation of [nuclear factor (NF)-kappaB] in PANC-1 cells , and the increase in chemokine mRNA expression correlated with NF-kappaB activation . Positive_regulation RELA TNF 10882136 709453 A dominant negative mutant of IKKepsilon blocks induction of NF-kappaB by both PMA and activation of the T cell receptor but has no effect on the *activation* of [NF-KB] by or IL-1 . Positive_regulation RELA TNF 10884313 709544 However , pretreatment with oATP downregulated *activation* of [NF-kappaB] and AP-1 by IL-1beta or . Positive_regulation RELA TNF 10890505 710562 We have previously demonstrated that 1 micromol/L HQ inhibits induced *activation* of [NFkappaB] in CD4+ T cells , resulting in decreased IL-2 production . Positive_regulation RELA TNF 10892347 711285 Gel-shift analysis of HUVEC demonstrated that pretreatment with pycnogenol exhibited a concentration dependent suppression of *induced* activation of [NF-kappa B] . Positive_regulation RELA TNF 10893342 711468 We tested the hypothesis that the *stimulated* transcription factor [nuclear factor (NF)-kappaB] could , in part , mediate TNF-alpha action by inhibiting the transcriptional potency of the VDR and RXR at their cognate cis regulatory sites . Positive_regulation RELA TNF 10903807 713242 The results indicate that , secreted by virus infected macrophages , *activates* [NF-kappa B] which impairs the IL-13 mediated inhibition of inducible NO synthase (iNOS) expression . Positive_regulation RELA TNF 10903915 713439 We demonstrated here that intracellular localization of these redox molecules differ from each other and that the redox molecules differentially regulate [NF-kappaB] , AP-1 , and CREB activation *induced* by , PMA , and forskolin and by expression of signaling intermediate kinases , NIK , MEKK , and PKA in HEK293 cells . Positive_regulation RELA TNF 10908694 715623 These genes are regulated by the transcription factor [NFkappaB] which in turn is *activated* by and cytokines . Positive_regulation RELA TNF 10918504 716999 The expression of several cytokines and adhesion molecules is regulated by the transcription factor [NFkappaB] , which is *activated* by . Positive_regulation RELA TNF 10919278 717221 Recently , it has been reported that tumor necrosis factor-alpha (TNF-alpha) activates the release of ceramide and that ceramide acts as a mediator for the *induced* stimulation of the binding affinity of [nuclear factor-KB (NF-KB)] , a ubiquitous transcription factor of particular importance in immune and inflammatory responses . Positive_regulation RELA TNF 10919278 717223 In this study we demonstrate that dexamethasone , which reduces the production of ceramide , significantly inhibits *induced* activation of [NF-KB] , c-Jun N-terminal kinase , also known as stress activating protein kinase , caspase-3-like cysteine protease , redistribution of cytochrome c , and apoptosis in MC3T3E1 osteoblasts . Positive_regulation RELA TNF 10919658 717261 Oleandrin blocked *induced* activation of [NF-kappaB] in a concentration- and time dependent manner . Positive_regulation RELA TNF 10919658 717265 A proprietary hot water extract of oleander ( Anvirzel ) also blocked induced [NF-kappaB] *activation* ; Positive_regulation RELA TNF 10919658 717267 The effects of oleandrin were not cell type specific , because it blocked induced [NF-kappaB] *activation* in a variety of cells . Positive_regulation RELA TNF 10926553 718851 Challenge with H ( 2 ) O ( 2 ) also failed to induce NF-kappaB-driven reporter gene expression in the transduced HMEC-1 cells , whereas *increased* the [NF-kappaB-driven] gene expression approximately 10-fold . Positive_regulation RELA TNF 10926553 718854 Gel supershift assay revealed the presence of p65 ( Rel A ) , p50 , and c-Rel in both H ( 2 ) O ( 2 ) - and *induced* [NF-kappaB] complexes bound to the ICAM-1 promoter , with the binding of the p65 subunit being the most prominent . Positive_regulation RELA TNF 10930442 719832 Here we demonstrate that the *activation* of [NF-kappa B] by interferes with thyroid-hormone action as demonstrated by impairment of T ( 3 ) -dependent induction of 5'-DI gene expression in HepG2 cells . Positive_regulation RELA TNF 10930442 719837 Furthermore , we show that an inhibitor of NF-kappa B activation , clarithromycin (CAM) , can inhibit induced *activation* of [NF-kappa B] and restore T ( 3 ) -dependent induction of 5'-DI mRNA and enzyme activity . Positive_regulation RELA TNF 10930442 719840 These results suggest that [NF-kappa B] *activation* by is involved in the pathogenesis of euthyroid sick syndrome and that CAM could help prevent a decrease in serum T ( 3 ) levels and thus ameliorate euthyroid sick syndrome . Positive_regulation RELA TNF 10938077 737432 , as well as certain other stimuli , also *induces* the phosphorylation of the [NF-kappaB] proteins . Positive_regulation RELA TNF 10938077 737437 Previously , we have shown that induces RelA/p65 phosphorylation at serine 529 and that this inducible phosphorylation *increases* [NF-kappaB] transcriptional activity on an exogenously supplied reporter ( ) . Positive_regulation RELA TNF 10940316 721033 [NFkappaB] activation in *response* to and bleomycin , the latter causing topoisomerase II-independent DNA damage , was intact in both cell lines . Positive_regulation RELA TNF 10946303 722951 [NF-kappaB] DNA-protein binding and COX-2 promoter activity were *enhanced* by , and these effects were inhibited by genistein , U73122 , staurosporine , or pyrolidine dithiocarbamate . Positive_regulation RELA TNF 10956637 724799 Gel shift and Western blot analyses confirmed that *activated* [NF-kappaB] and depleted IkappaB in this system and that these effects were prevented by MG-132 and pyrrolidine dithiocarbamate . Positive_regulation RELA TNF 10963848 727472 We also demonstrate that histaglobin inhibits the nuclear translocation of [NF-kappaB] in *response* to or lipopolysaccharide (LPS) in bone marrow derived macrophages of Balb/c mice . Positive_regulation RELA TNF 10970832 728841 To determine whether altered signal transduction through the nuclear factor (NF)-kappaB pathway occurs in CF epithelial cells and results in excessive generation of inflammatory cytokines , we evaluated induced production of the NF-kappaB dependent cytokine interleukin (IL)-8 and *activation* of [NF-kappaB] in three different human bronchial epithelial cell lines : ( 1 ) BEAS cells that express wild-type CF transmembrane conductance regulator ( CFTR ) , ( 2 ) IB3 cells with mutant CFTR , and ( 3 ) C38 cells , which are `` corrected '' IB3 cells complemented with wild-type CFTR . Positive_regulation RELA TNF 10973919 729088 Expression of Rac1N17 blocked *induced* activation of [nuclear factor-kappa B (NF-kappaB)] , increased activity of caspase-3 , and markedly augmented endothelial cell susceptibility to TNF induced apoptosis . Positive_regulation RELA TNF 10976991 729647 In the present study , we investigated effects of a synthetic glucocorticoid , dexamethasone ( Dex ) , on dependent *activation* of [NF-kappaB] and expression of the ICAM-1 gene . Positive_regulation RELA TNF 10976991 729652 Electrophoretic mobility shift assay ( EMSA ) revealed that dependent *activation* of [NF-kappaB] was almost completely suppressed by Dex treatment . Positive_regulation RELA TNF 10982546 732002 Adiponectin suppressed induced IkappaB-alpha phosphorylation and subsequent [NF-kappaB] *activation* without affecting other TNF-alpha mediated phosphorylation signals , including Jun N-terminal kinase , p38 kinase , and Akt kinase . Positive_regulation RELA TNF 10984605 732230 The present study investigates the role of Akt in the *activation* of [NF-kappa B] by ( TNF alpha , 10 ng/ml ) and PDGF-BB ( 20 ng/ml ) in human vascular smooth muscle cells (SMC) , skin and foreskin fibroblasts . Positive_regulation RELA TNF 10984605 732249 *stimulated* serine phosphorylation and degradation of the inhibitory protein I kappa B alpha and strongly induced nuclear [NF-kappa B] translocation and binding activity . Positive_regulation RELA TNF 10993753 733452 Stimulation of myocytes with *resulted* in a 12.1-fold increase ( P < 0.01 ) in [NF-kappa B-dependent] gene transcription and DNA binding compared with controls . Positive_regulation RELA TNF 10993753 733454 Adenovirus mediated delivery of a nonphosphorylatable form of I kappa B alpha to inactivate NF-kappa B prevented *stimulated* NF-kappa B-dependent gene transcription and nuclear [NF-kappa B] DNA binding . Positive_regulation RELA TNF 11002422 734655 In this study , we demonstrate that the proteolytic cleavage of receptor interacting protein ( RIP ) by caspase-8 during TNF induced apoptosis abrogates the stimulatory role of RIP on induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 11002422 734658 Ectopic expression of the pro-apoptotic C-terminal fragment of RIP inhibited induced [NF-kappaB] *activation* by suppressing the activity of I-kappaB kinasebeta (IKKbeta) which phosphorylates I-kB , an inhibitor of NF-kappaB , and triggers its ubiquitin mediated degradation . Positive_regulation RELA TNF 11003979 734876 We recently reported that rapidly *activates* [NF-kappaB] in differentiated skeletal muscle myotubes and that TNF-alpha acts directly on the muscle cell to induce protein degradation . Positive_regulation RELA TNF 11006087 735182 Pyrrolidine dithiocarbamate inhibits dependent *activation* of [NF-kappaB] by increasing intracellular copper level in human aortic smooth muscle cells . Positive_regulation RELA TNF 11006087 735186 In the present study , we investigated effects of PDTC and another antioxidant , N-acetyl-l-cysteine (NAC) , on dependent *activation* of [NF-kappaB] in human aortic smooth muscle cells ( HASMC ) . Positive_regulation RELA TNF 11006087 735193 These results indicate that TNF-alpha dependent expression of MCP-1 in HASMC is tightly regulated by NF-kappaB and that intracellular copper level is crucial for the *dependent* activation of [NF-kappaB] in HASMC . Positive_regulation RELA TNF 11007940 735631 The promoter regions of the human gamma-GCS subunits contain AP-1 , [NF-kappa B] , and antioxidant response elements and are *regulated* by oxidants , growth factors , inflammatory cytokine , and anti-inflammatory agent ( dexamethasone ) in lung cells . Positive_regulation RELA TNF 11007940 735642 also *induces* the activation of [NF-kappa B] and AP-1 and the subsequent increase in gamma-GCS heavy subunit transcription in these cells . Positive_regulation RELA TNF 11007945 735648 It has also been reported that [NF-kappa B] *activation* by , chemotherapeutic drugs , or ionizing radiations can protect several cell types against apoptosis , suggesting that NF-kappa B could participate in resistance to cancer treatment . Positive_regulation RELA TNF 11009421 735887 Failure to regulate *induced* [NF-kappaB] and cell death responses in A20-deficient mice . Positive_regulation RELA TNF 11009421 735890 A20 is a cytoplasmic zinc finger protein that inhibits [nuclear factor kappaB (NF-kappaB)] activity and *mediated* programmed cell death (PCD) . Positive_regulation RELA TNF 11009421 735894 A20-deficient cells fail to terminate *induced* [NF-kappaB] responses . Positive_regulation RELA TNF 11009421 735899 Thus , A20 is critical for limiting inflammation by terminating *induced* [NF-kappaB] responses in vivo . Positive_regulation RELA TNF 11009425 735903 The transcription factor [nuclear factor kappa B (NF-kappaB)] is *activated* by the cytokine , a mediator of skeletal muscle wasting in cachexia . Positive_regulation RELA TNF 11009425 735908 In differentiating C2C12 myocytes , induced *activation* of [NF-kappaB] inhibited SMD by suppressing MyoD mRNA at the posttranscriptional level . Positive_regulation RELA TNF 11018074 737679 In wild-type mice , ethanol caused severe liver injury via a mechanism involving gut derived endotoxin , CD14 receptor , production of electron spin resonance-detectable free radicals , *activation* of the transcription factor [NF-kappaB] , and release of cytotoxic from activated Kupffer cells . Positive_regulation RELA TNF 11023661 738335 Although both IL-1 and *activate* [NF-kappaB] in these cells , only IL-1 induces collagenase-1 transcription . Positive_regulation RELA TNF 11029374 739837 The degree to which albumin increased GSH levels was sufficient to protect cells against H ( 2 ) O ( 2 ) -mediated cytotoxicity and to decrease mediated [NF-kappaB] *activation* . Positive_regulation RELA TNF 11031204 740161 Electromobility gel shift and luciferase assays demonstrated that overexpression of IkappaBDeltaN inhibited [NF-kappaB] activation *induced* by or interleukin-1beta (IL-1beta) . Positive_regulation RELA TNF 11045567 742606 Primary embryonic fibroblasts derived from mice with a null mutation in Peg3 showed no abnormalities in *induced* nuclear translocation of [nuclear factor kappaB (NF-kappaB)] or phosphorylation of the mitogen activated protein kinases , extracellular signal regulated kinases 1 and 2 , c-Jun N-terminal kinase/stress activated protein kinase ( JNK/SAPK ) , and p38 . Positive_regulation RELA TNF 11046018 742742 Because the nuclear transcription factors NF-kappaB and AP-1 have recently been reported to mediate anti-apoptosis and cell survival , we hypothesized that IFN-alpha potentiates the cytotoxic effects of TNF by suppressing induced *activation* of [NF-kappaB] and AP-1 . Positive_regulation RELA TNF 11046018 742745 We tested this hypothesis by pretreating human Jurkat T cells with IFN-alpha , which blocked *induced* activation of [NF-kappaB] and AP-1 in a time- and dose dependent manner as determined by EMSA . Positive_regulation RELA TNF 11067942 747605 These results indicate that sustained [NF-kappaB] activation in asthmatic bronchi is driven by granulocytes and is *mediated* by IL-1beta and . Positive_regulation RELA TNF 11067959 747609 Previously , we have demonstrated that leflunomide inhibits induced [NF-kappaB] *activation* by suppressing I-kappaBalpha ( inhibitory subunit of NF-kappaB ) degradation . Positive_regulation RELA TNF 11068016 747628 Furthermore , *increased* [NF-kappaB] DNA binding , which was abolished by pretreatment with pyrrolidine dithiocarbamate . Positive_regulation RELA TNF 11083876 810019 Inhibition of TLR2 had no effect on alpha *induced* [NF-kappaB] or AP-1 activation , on the DNA binding of the basal transcription factor Oct-1 , or on hydrogen peroxide induced phosphorylation of p38 MAP kinase . Positive_regulation RELA TNF 11087727 786359 *induces* distinctive [NF-kappa B] signaling within human dermal fibroblasts . Positive_regulation RELA TNF 11087727 786361 Further , [NF-kappa B] *activation* by was unaffected by overexpression of a dominant negative mutant NIK in fibroblasts , despite detection of endogenous TRAF2 and NIK by Western analysis . Positive_regulation RELA TNF 11093734 755023 binding to the TNF receptor (TNFR) initiates apoptosis and simultaneously *activates* the transcription factor , [nuclear factor-kappaB (NF-kappaB)] , which suppresses apoptosis by an unknown mechanism . Positive_regulation RELA TNF 11096064 802159 To test the hypothesis that fluid flow alters NF-kappaB activation and expression of cell adhesion molecules in osteoblastic cells , we examined the effect of oscillating fluid flow ( OFF ) on induced [NF-kappaB] *activation* in rat osteoblast-like UMR106 cells . Positive_regulation RELA TNF 11096064 802162 We found that OFF inhibits NF-kappaB-DNA binding activities , especially *induced* p50-p65 heterodimer [NF-kappaB] activation and TNF-alpha induced intercellular adhesion molecule-1 mRNA expression . Positive_regulation RELA TNF 11096064 802165 The inhibitory effects of OFF on both *induced* [NF-kappaB] activation and intercellular adhesion molecule-1 mRNA expression were shear stress dependent and also increased with OFF exposure duration , indicating that OFF has potent effects on mechanotransduction pathways . Positive_regulation RELA TNF 11096064 802173 Thus , OFF inhibits TNF-alpha induced IKK activation , leading to a decrease in phosphorylation and degradation of inhibitory IkappaBalpha , which in turn results in the decrease of *induced* [NF-kappaB] activation and potentially the transcription of target genes . Positive_regulation RELA TNF 11104733 756513 Stimulation of HASM cells with *increased* [NF-kappaB] DNA binding activity . Positive_regulation RELA TNF 11104733 756517 However , increased [ cAMP ] ( i ) in HASM neither activated NF-kappaB nor altered *induced* [NF-kappaB] DNA binding activity . Positive_regulation RELA TNF 11108246 756745 However , *induced* [NF-kappaB] DNA binding activity is independent of p38MAPK and ERK activation . Positive_regulation RELA TNF 11112416 757590 *Activation* of [NF-kappa B] by mediates many functions of TNF-alpha . Positive_regulation RELA TNF 11112416 757596 In MCF-7 cells ( an estrogen and TNF-alpha receptor positive cell line ) , treatment with 17 beta-estradiol ( E ( 2 ) ) inhibited *induced* [NF-kappa B] DNA binding activity in the gel retardation assays . Positive_regulation RELA TNF 11112449 757636 dependent *activation* of [NF-kappa B] in human osteoblastic HOS-TE85 cells is repressed in vector averaged gravity using clinostat rotation . Positive_regulation RELA TNF 11112449 757640 Effects of vector averaged gravity on dependent *activation* of [nuclear factor kappa B (NF-kappa B)] in human osteoblastic HOS-TE85 cells were investigated by culturing the cells using clinostat rotation ( clinorotation ) . Positive_regulation RELA TNF 11112449 757644 Electrophoretic mobility shift assays revealed that dependent *activation* of [NF-kappa B] was markedly reduced in the clinorotated cells when compared with the cells in control stationary cultures or after horizontal rotation ( motional controls ) . Positive_regulation RELA TNF 11112449 757648 Consistent with these findings , the dependent *induction* of endogenous [NF-kappa B-responsive] genes p105 , I kappa B-alpha , and IL-8 , was significantly attenuate in clinorotated cells . Positive_regulation RELA TNF 11115778 757919 Electrophoretic mobility shift assays ( EMSAs ) revealed that IL-1 beta and *activate* the transcription factor [NF kappa B] in reaggregates of rat anterior pituitaries and in TtT/Gf cells cultured alone or cocultured with GH3 cells . Positive_regulation RELA TNF 11116146 786598 [NF-kappaB] *activation* by the involves the formation of a multiprotein complex termed a signalosome . Positive_regulation RELA TNF 11118442 786655 can also *promote* [nuclear factor kappaB (NF-kappaB)] activity and regulate the expression of genes that interfere with apoptosis and thus conferring resistance to several apoptotic stimuli . Positive_regulation RELA TNF 11118442 786658 These findings show that NO might interfere with dependent [NF-kappaB] *activation* by interacting with O ( 2 ) and reducing the generation of H ( 2 ) O ( 2 ) , a potent NF-kappaB activator . Positive_regulation RELA TNF 11120942 768507 We examined whether or not clarithromycin inhibits the activation of [NF-kappaB] *induced* by or staphylococcal enterotoxin A (SEA) in human monocytic U-937 cells , a T-cell line ( Jurkat ) , a pulmonary epithelial cell line ( A549 ) , and peripheral blood mononuclear cells ( PBMC ) . Positive_regulation RELA TNF 11120942 768509 Flow cytometry revealed that clarithromycin suppresses [NF-kappaB] activation *induced* by in U-937 and Jurkat cells in a concentration related manner . Positive_regulation RELA TNF 11120942 768511 Western blot analysis also demonstrated that clarithromycin inhibits [NF-kappaB] activation *induced* by in U-937 , Jurkat , and A549 cells and PBMC and by SEA in PBMC . Positive_regulation RELA TNF 11133232 769109 Importantly , expression of I kappa B ( S32A , S36A ) results in complete abrogation of myocardial [NF-kappa B] activation in *response* to and LPS stimulation . Positive_regulation RELA TNF 11133489 769145 ASA inhibited *induced* activation of [NF-kappa B] by preventing phosphorylation and subsequent degradation of I kappa B-alpha in a prostanoid independent manner . Positive_regulation RELA TNF 11160233 781554 Of interest , *mediated* activation of the cellular transcription factor [NF-kappaB] was unaffected by PTX-B . Positive_regulation RELA TNF 11162606 782275 BIM did not inhibit [NF-kappa B] *activation* by but caused activation of caspases and enhanced cleavage of PKC delta and -epsilon . Positive_regulation RELA TNF 11162639 782341 Homocysteine attenuated TNF-alpha stimulated U-937 adhesion to the endothelial monolayer and reduced induced *activation* of the transcription factor [NF-kappaB] , indicating that NF-kappaB inhibition may play a role in inhibiting expression of adhesion molecules in endothelial cells . Positive_regulation RELA TNF 11165942 782865 However , the specific inhibitor of p38 MAPK , SB203580 , had no effect on *induced* [NF-kappaB] activation and both NF-kappaB inhibitors failed to reduce the p38 MAPK activation in the TNF-alpha stimulated osteoblasts . Positive_regulation RELA TNF 11191283 761395 *activated* [NF-kappaB] in gel shift experiments without inducing iNOS -- as assessed by nitrite formation -- whereas IL-1beta stimulated both NF-kappaB activation and iNOS induction . Positive_regulation RELA TNF 11191283 761400 However , both ceramide and potentiated IL-1beta- *induced* activation of [NF-kappaB] and iNOS . Positive_regulation RELA TNF 11198351 779641 We addressed the role of the redox state of endothelial cells in modulating *induced* [NF-kappaB] activity . Positive_regulation RELA TNF 11198351 779651 Stimulation of control cells with *resulted* in reactive oxygen species ( ROS ) generation and activation of [NF-kappaB] binding to the ICAM-1 promoter and ICAM-1 transcription . Positive_regulation RELA TNF 11200499 762160 The designed compound , DHM2EQ , inhibited induced *activation* of [NF-kappaB] and showed a therapeutic effect in mouse rheumatoid arthritis model . Positive_regulation RELA TNF 11212226 785779 Follow-up analyses demonstrated that , although *activated* [NF-kappaB] through IkappaB-alpha degradation , alpha-Fas treatment led to NF-kappaB activation through a mechanism distinct from IkappaB-alpha degradation . Positive_regulation RELA TNF 11223427 787889 *stimulated* the translocation of [nuclear factor-kappaB (NF-kappaB)] , an effect that was not modified by cerivastatin . Positive_regulation RELA TNF 11225736 580994 In the present study , we analyzed the signaling pathway by which *activates* [NF-kappaB] in myotubes differentiated from C2C12 and rat primary myoblasts . Positive_regulation RELA TNF 11225736 580998 We found that *activation* of [NF-kappaB] by was blocked by rotenone or amytal , inhibitors of complex I of the mitochondrial respiratory chain . Positive_regulation RELA TNF 11228746 581000 *induced* [NF-kappa B] activation was inhibited by both superoxide and lipid peroxide quenchers but potentiated by an hydroxyl radical quencher . Positive_regulation RELA TNF 11228746 581017 Overall , these results suggest that hydroxyl radicals mediate *induced* apoptosis but not activation of [NF-kappa B] , AP-1 , and JNK ; Positive_regulation RELA TNF 11235987 764121 Moreover , antioxidants inhibited *induced* osteosarcoma cell invasion , motility and [NFkappaB] nuclear translocation , but not adhesion to laminin or MMP9 expression . Positive_regulation RELA TNF 11237861 790425 In the present study we investigated how TSH is involved in the *activation* of [NF-kappaB] by in the cells . Positive_regulation RELA TNF 11238809 791142 Effects of SAC on hydrogen peroxide ( H ( 2 ) O ( 2 ) ) or *induced* [nuclear factor (NF)-kappa B] activation were determined . Positive_regulation RELA TNF 11238809 791144 SAC also inhibited H ( 2 ) O ( 2 ) - or *induced* [NF-kappa B] activation . Positive_regulation RELA TNF 11243852 792250 Transient transfection study of NF-kappaB promoter construct and electrophoretic mobility shift assay suggested that hematein inhibited both NF-kappaB dependent gene expression and [NF-kappaB] activation *induced* by . Positive_regulation RELA TNF 11257457 794472 The luciferase assay demonstrated that overexpression of EXTL3 enhanced *induced* [NF-kappaB] activity . Positive_regulation RELA TNF 11257457 794478 These results suggest that EXTL3 may modulate [NF-kappaB] *mediated* by . Positive_regulation RELA TNF 11262181 796266 Here , we addressed the question of whether small GTPases of the Rho family are involved in the *stimulation* of [NF-kappaB] signaling by genotoxic agents or in HeLa cells . Positive_regulation RELA TNF 11262181 796273 Specific blockage of Rho signaling by Clostridium difficile toxin B attenuated UV- and doxorubicin induced activation of NF-kappaB , but did not affect *stimulation* of [NF-kappaB] by . Positive_regulation RELA TNF 11266388 796752 and Jo2 *induced* iNOS messenger RNA and protein levels through the induction of [NF-kappaB] . Positive_regulation RELA TNF 11266466 796903 Overexpression of a Y42F mutant of IkappaBalpha potently suppressed NFG- , but not *induced* [NFkappaB] activation . Positive_regulation RELA TNF 11266466 796910 We conclude that NGF and *induce* different signaling pathways in neurons to activate [NFkappaB] and bcl-x gene expression . Positive_regulation RELA TNF 11279196 819637 Overexpression of the icp75TNFR cDNA results in *induced* activation of [NFkappaB] in a TNF receptor associated factor 2 (TRAF2) dependent manner . Positive_regulation RELA TNF 11280761 798765 VEGF effectively blocked induced [NF-kappaB] *activation* in HPCs from RelB-/- mice , however , similar to the effect observed in HPCs obtained from RelB+/- and RelB+/+ mice . Positive_regulation RELA TNF 11280761 798773 Thus , VEGF appears to inhibit *induced* [NF-kappaB] activation by VEGFR kinase independent inhibition of IKK . Positive_regulation RELA TNF 11289659 800572 S-nitrosoglutathione inhibits induced [NFkappaB] *activation* in neutrophils . Positive_regulation RELA TNF 11289659 800574 *increased* nuclear [NFkappaB] activity compared to unstimulated neutrophils ( p < 0.001 , n = 5 ) . Positive_regulation RELA TNF 11289659 800578 GSNO ( 500 microM ) decreased *induced* [NFkappaB] activity ( p < 0.05 ) and inhibited NFkappaB activity whether given prior to or during TNFalpha exposure . Positive_regulation RELA TNF 11306890 804341 [NF-kB] signaling *induced* by is suppressed by IFNalpha and IFNgamma in the permanent cell lines and in the primary RCC tumor cell cultures . Positive_regulation RELA TNF 11309390 820012 Activation of [NF-kappaB] in *response* to and glutamate was completely abolished when IP ( 3 ) receptors were blocked , and NF-kappaB activation in response to depletion of ER calcium by thapsigargin treatment was also decreased by IP ( 3 ) receptor blockade . Positive_regulation RELA TNF 11313989 806214 Moreover , induction of p53 interfered with induced [NF-kappaB] *activation* independently from apoptosis-induction . Positive_regulation RELA TNF 11316563 806484 [NF-kappaB] is *activated* by , certain chemotherapeutic agents , and ionizing radiation , leading to inhibition of apoptosis . Positive_regulation RELA TNF 11318879 806749 Although the *induction* of [NF-kappaB] by dsRNA/virus and involves common downstream pathways including IKK activation , the upstream , Geldanamycin-sensitive process was unique to the dsRNA/virus induced signal . Positive_regulation RELA TNF 11322949 807240 ( iv ) IFNalpha treatment attenuated *induced* [NF-kappaB] reporter activity , while it did not inhibit DNA binding of NF-kappaB . Positive_regulation RELA TNF 11322949 807242 Taken collectively , our results indicate that IFNalpha sensitizes ME-180 cells to TNFalpha induced apoptosis by inhibiting *mediated* cytoprotective [NF-kappaB] activation , and this sensitizing effect of IFNalpha is mediated through a STAT1 dependent pathway . Positive_regulation RELA TNF 11336164 809295 and IL-1 *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 11336543 812036 However , [NF kappa B] *activation* by was not significantly altered by the HCV core protein , suggesting the existence of TRAF2 independent pathways for NF kappa B activation . Positive_regulation RELA TNF 11337375 812181 *induced* maximal translocation of [NF-kappaB] into the nucleus of non-CF as well as CF airway cells within 20 minutes . Positive_regulation RELA TNF 11337489 827568 We have demonstrated that overexpression of the EGF receptor (EGFR) in NIH3T3 cells significantly enhances *induced* [NF-kappa B-dependent] luciferase activity even without EGF , that EGF treatment has a synergistic effect on the induction of the reporter activity , and that this enhancement is suppressed by AG1478 , EGFR-specific tyrosine kinase inhibitor . Positive_regulation RELA TNF 11337489 827580 Taken together , this evidence strongly suggests that EGFR transactivation by TNF , which is regulated in a redox dependent manner , is playing a pivotal role in *induced* [NF-kappa B] activation . Positive_regulation RELA TNF 11340079 827661 Here we show that antisense oligonucleotide induced inhibition of FLASH expression abolished induced *activation* of [NF-kappaB] in HEK293 cells , as determined by luciferase reporter gene expression driven by a NF-kappaB responsive promoter . Positive_regulation RELA TNF 11340302 812461 Increased binding activity of [NFkappaB] *induced* by was effectively blocked by the NFkappaB decoy ODN . Positive_regulation RELA TNF 11342564 827723 induced *activation* of [NF-kappa B-dependent] gene expression is not modulated by LiCl treatment . Positive_regulation RELA TNF 11344085 814129 *activated* [nuclear factor-kappaB (NF-kappaB)] and interfered with the expression of muscle proteins in differentiating myoblasts . Positive_regulation RELA TNF 11350953 834343 Our results indicate that overexpression of cRel or *activation* of endogenous [Rel/NF-kappaB] factors by in HeLa cells up-regulates DcR1 without changing the expression of DcR2 , DR4 , and DR5 and makes cells resistant against TRAIL induced apoptosis . Positive_regulation RELA TNF 11356844 834435 Activation of phosphatidylinositol (PI) 3-kinase/Akt signaling by *activates* IKK and [NF-kappaB] . Positive_regulation RELA TNF 11356844 834467 activated Akt in PC-3 cells , but not in DU145 cells , and the ability of TNF to activate [NF-kappaB] was *blocked* by pharmacological inhibition of PI 3-kinase activity in PC-3 cells , but not in DU145 cells . Positive_regulation RELA TNF 11359904 816572 Treatment of SV80 cells with the proteasome inhibitor N-benzoyloxycarbonyl ( Z ) -Leu-Leu-leucinal ( MG-132 ) or geldanamycin , a drug interfering with induced [NF-kappaB] *activation* , inhibited TNF induced upregulation of cFLIP . Positive_regulation RELA TNF 11368927 817345 Soy isoflavone supplementation in healthy men prevents [NF-kappa B] *activation* by in blood lymphocytes . Positive_regulation RELA TNF 11368927 817347 In this study , we have demonstrated that genistein , but not daidzein , inhibits induced [NF-kappa B] *activation* in cultured human lymphocytes . Positive_regulation RELA TNF 11368927 817349 Additionally , we investigated the in vivo effect of soy isoflavone supplementation on [NF-kappa B] activation *induced* by in vitro in peripheral blood lymphocytes of six healthy men . Positive_regulation RELA TNF 11374864 817886 Hepatitis C virus core protein potentiates *induced* [NF-kappaB] activation through TRAF2-IKKbeta dependent pathway . Positive_regulation RELA TNF 11374864 817888 Previous work has implicated that the core protein of hepatitis C virus ( HCV ) may play a modulatory effect on [NF-kappaB] activation *induced* by . Positive_regulation RELA TNF 11374864 817890 Here we show that overexpression of HCV core protein potentiates [NF-kappaB] activation *induced* by . Positive_regulation RELA TNF 11374864 817898 In addition , HCV core protein associates with TNF-R1-TRADD-TRAF2 signaling complex , resulting in synergistically activation of [NF-kappaB] *induced* by . Positive_regulation RELA TNF 11382928 820944 *induces* [NFkappaB/p50] in association with the growth and morphogenesis of normal and transformed rat mammary epithelial cells . Positive_regulation RELA TNF 11382928 820950 There were no changes in the levels of p65 or c-rel . *induced* a pronounced and sustained increase of a p50 homodimeric [NFkappaB/DNA] complex in both normal and transformed MEC . Positive_regulation RELA TNF 11389905 822431 Here , we show that a minimum of four zinc fingers is required to inhibit induced [nuclear factor-kappaB (NF-kappaB)] *activation* to a level that is comparable to that obtained with the wild-type A20 protein . Positive_regulation RELA TNF 11389905 822433 Moreover , we demonstrate that complete loss of binding of any of these proteins correlates with complete loss of A20 's ability to inhibit induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 11390371 842548 and interleukin (IL)-1beta are potent *activators* of the transcription factor [NF-kappaB] , induced during inflammatory conditions . Positive_regulation RELA TNF 11390377 842606 [NF-kappaB] activation *induced* by and interleukin-1 is inhibited by overexpression of ABIN-2 . Positive_regulation RELA TNF 11391531 822933 Induction of Mdr1b expression by in rat liver cells is independent of p53 but *requires* [NF-kappaB] signaling . Positive_regulation RELA TNF 11399512 824220 Since induced [NF-kappa B] *activation* , cell cycle arrest , RB dephosphorylation , and E2F downregulation are indistinguishable in both cell lines , none of these factors is likely to be involved in the TNF induced anti-apoptotic mechanism in A375-6 cells . Positive_regulation RELA TNF 11410870 826497 In line with this , not only the *induced* activation of caspases and apoptosis but also that of [NF-kappaB] was enhanced by 1,25 ( OH ) ( 2 ) D ( 3 ) pre-treatment . Positive_regulation RELA TNF 11410870 826499 Furthermore , 1,25 ( OH ) ( 2 ) D ( 3 ) enhanced induced [NF-kappaB] *activation* in T47D cells suggesting that it potentiates TNF signaling in general . Positive_regulation RELA TNF 11415944 829176 Treatment with H2O2 also inhibited *induced* IkappaBalpha breakdown , [NF-kappaB] DNA binding activity , and NF-kappaB dependent transcription but had no effect on TNF-alpha induced IkappaBalpha phosphorylation or ubiquitination . Positive_regulation RELA TNF 11418646 830259 Although Akt has been reported to activate NF-kappaB , DMS and LY 294002 failed to prevent induced [NF-kappaB] *activation* , suggesting that the antiapoptotic effects of SphK and Akt are independent of NF-kappaB . Positive_regulation RELA TNF 11420300 830585 Deletion of the redox-sensitive domain of Ref-1 significantly inhibited *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 11420300 830588 Moreover , it seems that Ref-1 may act as a critical cofactor , mediating the *induced* [NF-kappaB] response in the vascular endothelium . Positive_regulation RELA TNF 11423913 831036 Neither U0126 nor LY294002 pretreatment affected induced *activation* of [NF-kappaB] , suggesting that the MAP kinase or PI3-kinase/Akt mediated anti-apoptotic effect induced by TNF was not relevant to NF-kappaB activation . Positive_regulation RELA TNF 11428868 831568 Furthermore , co-administration of U0126 and SB202190 did not affect the induced degradation of IkappaB-alpha and NF-kappaB nuclear translocation , indicating that [NF-kappaB] is *activated* by IL-1beta and independently of activation of MEK/MAPK and p38 pathways in hRPE cells . Positive_regulation RELA TNF 11429546 831652 The essential role of MEKK3 in *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 11429546 831663 Using mitogen activated protein kinase kinase kinase 3 ( MEKK3 ) -deficient fibroblast cells , we found that MEKK3 plays a critical role in induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 11429546 831670 The kinase activity of MEKK3 is pivotal to its function and , therefore , MEKK3 links RIP and IKK in induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 11431731 831884 Lastly , activation of the Akt/protein kinase B (PKB) , which has recently been implicated in [NF-kappaB] *activation* by PDGF , , and Ras , was also observed . Positive_regulation RELA TNF 11437539 832850 Furthermore , overexpression *activated* [NF- kappa B] , a mediator of anti-apoptotic pathways , in the myocardium . Positive_regulation RELA TNF 11438547 843384 In this report , by using macrophages derived from wild-type mice ( having both receptors ) and mice in which the gene for either p60 ( p60 ( -/- ) ) , or p80 ( p80 ( -/- ) ) , or both ( p60 ( -/- ) p80 ( -/- ) ) receptor have been deleted , we have redefined the role of these receptors in induced *activation* of [nuclear factor (NF)-kappa B] and of mitogen activated protein kinases . Positive_regulation RELA TNF 11438547 843386 *activated* [NF-kappa B] in a dose- and time dependent manner in wild-type macrophages but not in p60 ( -/- ) , p80 ( -/- ) , or p60 ( -/- ) p80 ( -/- ) macrophages . Positive_regulation RELA TNF 11444925 834163 Addition of proteasome inhibitor MG132 or adenoviral expression of a truncated I kappa B alpha ( I kappa B Delta N ) inhibited *induced* [NF-kappa B] nuclear translocation in a dose dependent manner . Positive_regulation RELA TNF 11445585 860036 We have shown previously that secretory nonpancreatic ( snp ) and cytosolic ( c ) phospholipase A(2) ( PLA(2) ) regulate [NF-kappaB] activation in *response* to or interleukin (IL)-1beta activation and that a functional coupling mediated by the 5-lipoxygenase (5-LO) metabolite leukotriene B ( 4 ) ( LTB ( 4 ) ) exists between snpPLA ( 2 ) and cPLA(2) in human keratinocytes . Positive_regulation RELA TNF 11445585 860049 In this study , we have further investigated the mechanisms of PLA(2) modulated NF-kappaB activation with respect to specific kinases involved in *stimulated* cPLA(2) phosphorylation and [NF-kappaB] activation . Positive_regulation RELA TNF 11445585 860055 The protein kinase C ( PKC ) inhibitors RO 31-8220 , Gö 6976 , and a pseudosubstrate peptide inhibitor of atypical PKCs attenuated arachidonic acid release , cPLA(2) phosphorylation , and [NF-kappaB] activation *induced* by or IL-1beta , thus indicating atypical PKCs in cPLA(2) regulation and transcription factor activation . Positive_regulation RELA TNF 11445585 860073 Hence , lambda/iotaPKC regulates snpPLA ( 2 ) /LTB ( 4 ) -mediated cPLA(2) activation , cellular arachidonic acid release , and [NF-kappaB] activation *induced* by and IL-1beta . Positive_regulation RELA TNF 11450703 836641 Thus , we investigated whether *activates* a transcription factor [nuclear factor kappaB (NF-kappaB)] in human chondrocyte-like cells ( HCS-2/8 ) and induces the expression of genes involved in the degradation of cartilage matrix . Positive_regulation RELA TNF 11450703 836652 Thus , it is shown that the *activation* of p65/p50 [NF-kappaB] by plays a cardinal role in inducing the expression of MMP-1 , MMP-3 , ICAM-1 , and COX-2 genes , which are involved in matrix degradation and inflammatory reaction in chondrocytes , leading to chondrocytic chondrolysis . Positive_regulation RELA TNF 11461927 850947 Modulation of apoptosis *inducing* ligand- induced [NF-kappa B] activation by inhibition of apical caspases . Positive_regulation RELA TNF 11461927 850953 Receptor interacting protein , an obligatory component of induced [NF-kappaB] *activation* , was cleaved during TRAIL induced apoptosis . Positive_regulation RELA TNF 11470788 860373 IKKgamma/NEMO is an essential regulatory component of the IkappaB kinase complex that is required for [NF-kappaB] activation in *response* to various stimuli including and interleukin-1beta . Positive_regulation RELA TNF 11472980 841553 Geldanamycin inhibited mediated [NF-kappaB] *activation* as measured by electromobility shift assays and transient transfections with a NF-kappaB dependent luciferase reporter plasmid . Positive_regulation RELA TNF 11474119 766078 The effect of H2O2 on induced *activation* of [nuclear factor kappa B (NF-kappaB)] was measured by Western blots of cytoplasmic and nuclear extracts of RBEC using anti-inhibitor of NF-kappaB ( IkappaB ) and anti-p65 subunit of NF-kappaB antibodies . Positive_regulation RELA TNF 11479302 860573 Critical roles of TRAF2 and TRAF5 in induced [NF-kappa B] *activation* and protection from cell death . Positive_regulation RELA TNF 11479302 860588 However , the exact roles of TRAF2 and TRAF5 in induced [NF-kappaB] *activation* still remain controversial . Positive_regulation RELA TNF 11479302 860598 Collectively , these results indicate that both TRAF2 and TRAF5 are involved in *induced* [NF-kappaB] activation and protection from cell death . Positive_regulation RELA TNF 11483407 844319 [NF-kappaB] DNA-protein binding and ICAM-1 promoter activity were *enhanced* by and these effects were inhibited by D 609 , calphostin C , or tyrphostin 23 , but not by PD 98059 or SB 203580 . Positive_regulation RELA TNF 11489936 845480 Late Erk1/2 activation was involved in *stimulated* [NF-kappa B] activation and cytokine induction . Positive_regulation RELA TNF 11489969 845543 Both and phorbol ester 12,0-tetradecanoylphorbol 13-acetate ( TPA ) *enhanced* [NF-kappaB] activity but only TPA increased HCMV replication . Positive_regulation RELA TNF 11494147 846182 In this study we demonstrate that *triggers* only modest proliferation , as well as p44/p42 mitogen activated protein kinase (MAPK) and [NF-kappaB] activation , in MM.1S multiple myeloma ( MM ) cells . Positive_regulation RELA TNF 11494147 846185 also *activates* [NF-kappaB] and markedly upregulates ( fivefold ) secretion of interleukin-6 (IL-6) , a myeloma growth and survival factor , in bone marrow stromal cells ( BMSCs ) . Positive_regulation RELA TNF 11494147 846193 Importantly , the proteasome inhibitor PS-341 abrogated *induced* [NF-kappaB] activation , induction of ICAM-1 or VCAM-1 , and increased adhesion of MM cells to BMSCs . Positive_regulation RELA TNF 11500927 847142 SME or Sal B significantly inhibited induced *activation* of [nuclear factor kappa B (NF-kappaB)] in HAECs ( 0.36- and 0.48-fold , respectively ) . Positive_regulation RELA TNF 11500933 847145 However , expression of neither p38beta nor its dominant negative mutant in mesangial cells interfered with *induced* translocation of [NF-kappaB] , the initial step of NF-kappaB activation . Positive_regulation RELA TNF 11500933 847147 While it is unclear whether p38beta regulates NF-kappaB transcription activity at other steps , it is apparent that p38beta does not affect induced [NF-kappaB] *activation* at the stage of nuclear translocation . Positive_regulation RELA TNF 11505050 847903 In HepG2 cells , both IFNalpha and acute alcohol treatment induced NF-kappaB activation and augmented *induced* [NF-kappaB] binding . Positive_regulation RELA TNF 11505050 847905 Pretreatment of HepG2 cells with IFNalpha resulted in the highest levels of [NF-kappaB] activation in *response* to or TNFalpha plus ethanol stimulation . Positive_regulation RELA TNF 11505407 847917 TNFalpha induced inhibition of the EpCAM expression is mediated by TNF receptor 1 through the receptor associated death domain protein ( TRADD ) and by the *activation* of [nuclear factor kappaB (NF-kappaB)] , and it can be blocked by dominant negative variants of TRADD and the NF-kappaB inhibitor , IkappaB . Positive_regulation RELA TNF 11506747 848007 These cells were found to constitutively express high levels of active [NF-kappaB] that can not be further *activated* by . Positive_regulation RELA TNF 11509005 848229 also *induced* [nuclear factor-kappaB (NF-kappaB)] translocation to the nucleus , an essential step in GM-CSF mRNA production . Positive_regulation RELA TNF 11509327 848295 Using primary passage-1 human tracheobronchial epithelial cell cultures and an immortalized human bronchial epithelial cell line , HBE1 , we observed that *enhanced* [NF-kappa B] transcriptional activity . Positive_regulation RELA TNF 11509327 848297 Pretreatment with N-acetyl-cysteine (NAC) ( 1 to 10 mM ) or glutathione ( 1 to 10 mM ) inhibited induced *activation* of [NF-kappa B] transcriptional activity and IL-8 promoter mediated reporter gene expression . Positive_regulation RELA TNF 11509327 848301 In contrast , elevated TRX protein levels in cells enhanced *dependent* [NF-kappa B] transcriptional activity and IL-8 promoter activity . Positive_regulation RELA TNF 11509639 848634 We investigated the effects of MTX on [NF-kappaB] activation *induced* by in Jurkat cells . Positive_regulation RELA TNF 11509639 848638 The treatment of these cells with MTX suppressed induced [NF-kappaB] *activation* with optimum effects occurring at 10 microM MTX for 60 min . Positive_regulation RELA TNF 11509639 848642 The suppression of *induced* [NF-kappaB] activation by MTX correlated with inhibition of IkappaBalpha degradation , suppression of IkappaBalpha phosphorylation , abrogation of IkappaBalpha kinase activation , and inhibition of NF-kappaB dependent reporter gene expression . Positive_regulation RELA TNF 11522182 852739 Tumor necrosis factor receptor (TNFR) p55 was the prominent receptor , as neutralizing antibodies to TNFR p55 , but not to TNFR p75 , blocked mediated [NF-kappa B] *activation* . Positive_regulation RELA TNF 11546645 856536 Similarly , *activated* [NF-kappa B] through TK , p42/44 , p38 MAPKs , and PARP pathways in SVEC cells . Positive_regulation RELA TNF 11556546 861079 Inhibitory action of nitric oxide on circulating *induced* [NF-kappaB] activity and COX-2 transcription in the endothelium of the brain capillaries . Positive_regulation RELA TNF 11556546 861082 This study investigated the hypothesis that nitric oxide ( NO ) acts as an endogenous modulator of *induced* [NF-kappaB] signaling and COX-2 transcription in the endothelium of the cerebral capillaries . Positive_regulation RELA TNF 11556546 861085 These results indicate that eNOS derived NO acts as an endogenous inhibitor of *induced* [NF-kappaB] activity and COX-2 transcription in the endothelium of the cerebral capillaries . Positive_regulation RELA TNF 11557763 875287 As both and PMA rapidly *induce* [NF-kappaB] activation this suggests that NEMO/IKKgamma dependent activation of the NF-kappaB pathway is necessary but not sufficient for up-regulation of TRAIL in T cells . Positive_regulation RELA TNF 11561906 862731 TGF-beta as well as *induced* activation of [NFKB] and upregulated bcl-xL . Positive_regulation RELA TNF 11562425 862791 SB203580 and PD98059 had little effect on *induced* [nuclear factor-kappa B (NF-kappa B)] activation as determined in cells transfected with a NF-kappa B-luciferase reporter construct . Positive_regulation RELA TNF 11572859 882355 Using confocal microscopy and cell fractionation studies , butyrate pretreatment of a human colon cell line ( HT-29 cells ) inhibited the *induced* nuclear translocation of the proinflammatory transcription factor [NF-kappaB] . Positive_regulation RELA TNF 11572998 864828 Both F094 and avicin G were found to be potent inhibitors of *induced* [NF-kappaB] . Positive_regulation RELA TNF 11575451 865002 Extracellular stimuli , notably interleukin-1beta (IL-1beta) and *activate* [NF-kappaB] nuclear translocation via IkappaB phosphorylation and degradation . Positive_regulation RELA TNF 11583588 865689 However , an IRAK-1 variant lacking only the N-terminal domain retained the ability of the full-length protein to potentiate both IL-1 beta and *induced* [NF-kappa B] activation . Positive_regulation RELA TNF 11592111 869679 Lipopolysaccharide (LPS) treatment of a microglial cell line ( N9 ) *induced* a time dependent activation of both p38 mitogen activated protein kinase ( p38 MAPK ) and [nuclear factor-kappaB (NFkappaB)] , with consequent increases in interleukin-1alpha (IL-1alpha) , , and nitric oxide ( NO ) production . Positive_regulation RELA TNF 11594795 870094 A20 , a TNF inducible gene , inhibits *mediated* apoptosis as well as [NF-kappa B] induced by this cytokine . Positive_regulation RELA TNF 11600498 903815 These results suggest that low but persistent IKK activity and I kappa B degradation lead to prolonged [NF-kappa B] nuclear translocation and maximal AT(1) up-regulation in the continued *presence* of . Positive_regulation RELA TNF 11675371 873168 CpG DNA and LPS synergistically *induce* production in RAW264.7 cells and J774 cells through activation of [NF-kappaB] . Positive_regulation RELA TNF 11676476 873425 BRE , a putative stress modulating gene , found able to down-regulate induced [NF-kappaB] *activation* upon overexpression , is now shown in human cells expressed as multiple mRNA isoforms . Positive_regulation RELA TNF 11682062 873992 Here we studied the effect of cPrG . HCl on induced *activation* of the transcription factor [nuclear factor kappaB (NF-kappaB)] . Positive_regulation RELA TNF 11682062 874009 cPrG . HCl inhibited neither the *induced* phosphorylation and degradation of inhibitor of nuclear factor-kappaB , nor the subsequent nuclear translocation and DNA binding of [NF-kappaB] . Positive_regulation RELA TNF 11689467 876276 Alpha-lipoic acid inhibits *induced* [NF-kappaB] activation and adhesion molecule expression in human aortic endothelial cells . Positive_regulation RELA TNF 11689467 876282 Furthermore , LA dose-dependently inhibited *induced* IkappaB kinase activation , subsequent degradation of IkappaB , the cytoplasmic NF-kappaB inhibitor , and nuclear translocation of [NF-kappaB] . Positive_regulation RELA TNF 11689467 876284 In contrast , *induced* [NF-kappaB] activation and adhesion molecule expression were not affected by ascorbic acid or by manipulating cellular glutathione status with l-2-oxo-4-thiazolidinecarboxylic acid , N-acetyl-l-cysteine , or d , l-buthionine-S , R-sulfoximine . Positive_regulation RELA TNF 11698503 878190 In naive cells , LPS , , and IL-1beta *induced* IkappaBalpha degradation , kinase phosphorylation , and [NF-kappaB] DNA binding . Positive_regulation RELA TNF 11704541 879296 Increased expression of MMP-9 and [NF-kappa B] activation *induced* by were inhibited by pyrrolidine dithiocarbamate and N-acetyl-L-cysteine but were not inhibited by curcumin . Positive_regulation RELA TNF 11712859 880314 Both troglitazone and 15d-PGJ ( 2 ) markedly inhibited induced [NF-kappaB] *activation* at 30 microM . Positive_regulation RELA TNF 11715495 581294 To investigate whether could *activate* the signaling [pathway-NF-kappa B/I-kappa] B alpha required for the expression of inducible nitric oxide synthase (iNOS) to induce endothelial cell apoptosis by nitric oxide ( NO ) . Positive_regulation RELA TNF 11717189 881909 IL-4 enhanced *induced* activation of the transcription factor [NF-kappaB] . Positive_regulation RELA TNF 11729200 904355 In this study , we explored a novel function of polymorphonuclear neutrophils ( PMN ) NAD(P)H oxidase in the mechanism of induced [NF-kappaB] *activation* and intercellular adhesion molecule-1 ( ICAM-1 ) expression in endothelial cells . Positive_regulation RELA TNF 11729200 904358 Induction of neutropenia using anti-PMN serum prevented the initial *induced* [NF-kappaB] activation and ICAM-1 expression in WT mice , indicating the involvement of PMN NAD(P)H oxidase in signaling these responses . Positive_regulation RELA TNF 11729200 904361 Thus , oxidant signaling by the PMN NAD(P)H oxidase complex is an important determinant of *induced* [NF-kappaB] activation and ICAM-1 expression in endothelial cells . Positive_regulation RELA TNF 11730360 884952 We found that both IL-1beta and could independently *activate* cytosolic [NF-kappaB] , direct its translocation into the nucleus , and induce iNOS monomer synthesis . Positive_regulation RELA TNF 11734559 914840 This interaction is a prerequisite for RIP3 mediated phosphorylation of RIP and subsequent attenuation of *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 11742346 897760 We find that the Siah1a SBD potentiates mediated [NF-kappa B] *activation* . Positive_regulation RELA TNF 11753638 890163 *induced* [NF-kappaB] activation but not AP-1 activation in LNCaP cells . Positive_regulation RELA TNF 11753679 890180 *induces* the expression of DR6 , a member of the TNF receptor family , through activation of [NF-kappaB] . Positive_regulation RELA TNF 11755130 890232 In circulating blood neutrophils , *induced* activation of [nuclear factor-kappa B (NF-kappa B)] , whereas , in tissue neutrophils , NF-kappa B had been already activated without any stimulation , and no further activation was induced by the treatment with TNF-alpha . Positive_regulation RELA TNF 11755929 898992 Both IL-1beta and *stimulated* [NF-kappaB] activity , iNOS mRNA and protein expression with massive nitrite/nitrate ( NOx ) production in rat VSMCs . Positive_regulation RELA TNF 11773980 890554 A549 human lung carcinoma cells were infected with adenoviral constructs carrying dominant negative mutants of Rac1 and IKK or constitutively active mutant of Rac1 , upstream effectors in mediated [NF-kappaB] *activation* . Positive_regulation RELA TNF 11775855 581318 LPS might activate [NF-kappa B] in the PIMs , and *induce* the increase of transcription and expression of gene ; Positive_regulation RELA TNF 11777983 899878 EMSAs demonstrated that IL-17 , IL-1beta , and *induced* [NF-kappaB] activation within 1.5 h after stimulation , and a blockade of NF-kappaB activation by the pyrrolidine derivative of dithiocarbamate and tosyl-phe-chloromethylketone markedly reduced the IL-17- , IL-1beta- , or TNF-alpha induced IL-6 gene expression . Positive_regulation RELA TNF 11796489 902213 In contrast , cell stimulation with the cytokine *allowed* activation of [NFkappaB] through phosphorylation , ubiquitination , and subsequent degradation of IkappaBalpha . Positive_regulation RELA TNF 11799112 922229 PTEN blocks *induced* [NF-kappa B-dependent] transcription by inhibiting the transactivation potential of the p65 subunit . Positive_regulation RELA TNF 11799112 922237 In this report , we utilized PTEN as a natural biological inhibitor of Akt activity to study the effects on induced *activation* of [NF-kappaB] . Positive_regulation RELA TNF 11799112 922239 We found that the reintroduction of PTEN into prostate cells inhibited *stimulated* [NF-kappaB] transcriptional activity . Positive_regulation RELA TNF 11799112 922276 PTEN failed to block *induced* IKK activation , IkappaBalpha degradation , p105 processing , p65 ( RelA ) nuclear translocation , and DNA binding of [NF-kappaB] . Positive_regulation RELA TNF 11804328 892580 Overexpression of LRR-1 suppressed the activation of [NF-KB] *induced* by 4-1BB or 2 . Positive_regulation RELA TNF 11811521 892763 [NF-kappaB] was *activated* by in all four cell types tested . Positive_regulation RELA TNF 11813164 907431 Consequently , *triggers* [NF-kappaB] mobilization from the cytoplasm to the nucleus , as determined by tracking the NF-kappaB subunit p65 by immunofluorescence and Western blot analysis . Positive_regulation RELA TNF 11813164 907433 Inhibition of mediated IkappaBalpha degradation and [NF-kappaB] *activation* by gliotoxin or the proteasome inhibitor MG-132 un-masks the caspase dependent pro-apoptotic properties of TNF-alpha . Positive_regulation RELA TNF 11821383 928885 CARD-8 was also found to negatively regulate [NF-kappaB] *activation* by stimulation and by ectopically expressed RICK , suggesting that this protein may control cell survival . Positive_regulation RELA TNF 11821416 922608 Here we show that overexpression of NS5A inhibits induced [nuclear factor kappaB (NF-kappaB)] *activation* in HEK293 cells , as determined by luciferase reporter gene expression and by electrophoretic mobility shift assay . Positive_regulation RELA TNF 11821416 922614 Our findings suggest a possible molecular mechanism that could explain the ability of NS5A to negatively regulate induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 11823712 909331 *activates* a transcription factor [NF-kappaB] that binds promoters of multiple genes , thus ensuring pleiotropic effects of TNF-alpha . Positive_regulation RELA TNF 11827262 909397 Here , we report that an adenovirus mediated gene transfer of NF-kappaB inhibitor , super-repressor I kappa B alpha ( Adv-SR-IkappaBalpha ) , blocked induced [NF-kappaB] *activation* and sensitized oral SCC cells to TNF killing . Positive_regulation RELA TNF 11831701 291259 The stimulatory effect of is *mediated* by induction of the transcription factor [NF-kappaB] , which specifically binds to the 18-bp repetitive sequence motif of the enhancer region . Positive_regulation RELA TNF 11835405 911412 Whether signal transducer and activator of transcription-1 ( STAT1 ) , which mediates interferon ( IFN ) signaling , also plays any role in the *mediated* activation of [NF-kappaB] , JNK , and apoptosis has not been established . Positive_regulation RELA TNF 11835405 911432 *activated* [NF-kappaB] , consisting of p50 and p65 , in both U3A and U3A-pSG91 cells in a dose- and time dependent manner , but the degree and rate of activation were slightly lower in U3A cells , as were IkappaBalpha degradation and NF-kappaB dependent reporter gene expression . Positive_regulation RELA TNF 11835405 911436 STAT1 was , however , required for IFNalpha mediated downregulation of induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 11837795 911525 Following heat shock , decreased *induced* [NF-kappaB] activation was observed and was associated with preservation of IkappaB-alpha and a decrease in phosphorylated IkappaB-alpha that correlated to inhibition of I kappa kinase (IKK) activity . Positive_regulation RELA TNF 11839649 911659 Recently , sulindac and other nonsteroidal anti-inflammatory drugs have been shown to inhibit mediated [NF-kappaB] *activation* . Positive_regulation RELA TNF 11839649 911661 We further show that sulindac inhibits *mediated* activation of [NF-kappaB] DNA binding and nuclear translocation of NF-kappaB . Positive_regulation RELA TNF 11841920 912264 HM from an animal model of ALD have increased nonheme iron content accompanied by increased generation of EPR detected radicals , [NF-kappaB] activation , and *induction* , all of which are normalized by ex vivo treatment of the cells with deferiprone . Positive_regulation RELA TNF 11843050 912381 inhibition *reduced* the [NF-kappaB] activation , and blocked a transient wave of epithelial cell proliferation 12 h after the injection . Positive_regulation RELA TNF 11847111 912589 It has been proposed that *mediated* activation of [NFkappaB] leads to down regulation of MyoD , however the mechanisms underlying TNFalpha effects on skeletal muscle remain poorly understood . Positive_regulation RELA TNF 11851362 913233 Electrophoretic mobility shift assay demonstrated that *induced* [nuclear factor- kappa B (NF-kappa B)-specific] DNA binding . Positive_regulation RELA TNF 11851362 913237 The I kappa B alpha mutant suppressed [NF-kappa B] activation *induced* by . Positive_regulation RELA TNF 11851362 913239 NAC abolished *induced* [NF-kappa B] activation and hypertrophic responses . Positive_regulation RELA TNF 11855810 914052 There was no difference , however , in the ability of heat shock to inhibit mediated [NF-kappaB] *activation* , IkappaBalpha degradation , IkappaB kinase activation , and macrophage chemotactic protein-1 expression in the HSF-1-/- cells compared to the HSF-1+/+ cells . Positive_regulation RELA TNF 11864612 917627 Geldanamycin ( GA ) , an antitumor agent that disrupts the formation of this heterocomplex , prevents *induced* activation of IKK and [NF-kappaB] . Positive_regulation RELA TNF 11864954 917685 Potential of rifamides to inhibit induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 11877450 937180 Also , treatment of cells with kamebakaurin prevented the *induced* expression of antiapoptotic [NF-kappaB] target genes encoding c-IAP1 ( hiap-2 ) and c-IAP2 ( hiap-1 ) , members of the inhibitor of apoptosis family , and Bfl-1/A1 , a prosurvival Bcl-2 homologue , and augmented the TNF-alpha induced caspase 8 activity , thereby resulting in sensitizing MCF-7 cells to TNF-alpha induced apoptosis . Positive_regulation RELA TNF 11886496 894184 Using CD62E , NF-kappa B , or AP-1-responsive promoter constructs , dimethylfumarate inhibited *induced* activation of the CD62E and the [NF-kappa B] but not the AP-1 promoter construct . Positive_regulation RELA TNF 11896607 920950 Silibinin inhibits constitutive and induced *activation* of [NF-kappaB] and sensitizes human prostate carcinoma DU145 cells to TNFalpha induced apoptosis . Positive_regulation RELA TNF 11896607 920954 In such a scenario , strong apoptotic agent , further *induces* [NF-kappaB] activation rather than inducing apoptosis . Positive_regulation RELA TNF 11896607 920956 Additional studies showed that silibinin also inhibits *induced* activation of [NF-kappaB] via IkappaBalpha pathway and subsequently sensitizes DU145 cells to TNFalpha induced apoptosis . Positive_regulation RELA TNF 11909725 923759 The compounds display good potency in inhibiting *induced* apoptosis and [NF kappa B] activation . Positive_regulation RELA TNF 11918294 925606 mediates polymethylmethacrylate particle *induced* [NF-kappaB] activation in osteoclast precursor cells . Positive_regulation RELA TNF 11922866 984270 DNA binding studies using NF-kappaB subunit specific binding ELISA demonstrated that RSV and *induced* different [NF-kappaB] binding complexes containing Rel A ( p65 ) and NF-kappaB1 ( p50 ) . Positive_regulation RELA TNF 11928721 927216 Electrophoretic mobility shift assay showed that proteasome inhibitors diminished *stimulated* [nuclear factor-kappa B (NF-kappaB)] activation in ECs . Positive_regulation RELA TNF 11934806 927871 Concomitantly , ExPLIs inhibited the LPS induced activation of [NF-kappaB] by LPS but not its *activation* by or IL-1 . Positive_regulation RELA TNF 11943206 928678 *activates* pro-inflammatory transcription factor [nuclear factor-kappaB (NF-kappaB)] by uncertain signalling mechanisms . Positive_regulation RELA TNF 11943805 928751 Moreover , little [nuclear factor-kappaB (NF-kappaB)] translocation is *induced* by in neurons of TNFRI -/- , whereas NF-kappaB subunit p65 is still translocated from the cytoplasm into the nucleus in neurons from wild-type and TNFRII -/- mice . Positive_regulation RELA TNF 11948689 930238 DeltaIkappaBalpha suppressed the transactivation of [NF-kappaB] *induced* by or TRAIL , as reflected by luciferase-reporter activity . Positive_regulation RELA TNF 11950023 930284 *induced* [NF-kappaB] nuclear translocation and DNA binding in all OA synovial tissue explants , although there were no consistent effects on AP-1 DNA binding . Positive_regulation RELA TNF 11950023 930286 Dexamethasone partially inhibits *induced* [NF-kappaB] DNA binding in human synovial tissue . Positive_regulation RELA TNF 11954826 930696 Hyperoxia prolongs *mediated* activation of [NF-kappaB] : role of IkappaB kinase . Positive_regulation RELA TNF 11954826 930699 Stimulation with alone *increased* [NF-kappaB] activation within 1 h and induced IkappaB alpha degradation within 0.5 h . Positive_regulation RELA TNF 11954826 930705 These data demonstrate that while hyperoxia alone does not affect activation of NF-kappaB , hyperoxia prolongs mediated *activation* of [NF-kappaB] . Positive_regulation RELA TNF 11956090 930966 Whereas AV1Y28 inhibited NF-kappaB activation by hydrogen peroxide and ferricyanide , it had no effect of induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 11956601 931212 Furthermore , NDPP1 is able to inhibit [NF-kappaB] activation *induced* by treatment in HepG2 cells . Positive_regulation RELA TNF 11960552 984298 *activated* [NF-kappaB] , along with IkappaBalpha degradation , occurred at 20 to 60 min in Hyal-2 cells post stimulation , but at the 20 min time point in both control and Hyal-1 cells . Positive_regulation RELA TNF 11961404 932609 SIN-1 inhibited the *induced* [NF-kappaB] binding activity . Positive_regulation RELA TNF 11967955 938056 Moreover , CCM was able to inhibit both the constitutional and *induced* [NF-kappaB] activation in a time dependent manner . Positive_regulation RELA TNF 11976329 954026 Stimulation of cells with *triggers* [NF-kappaB1] p105 proteolysis , releasing associated Rel subunits to translocate into the nucleus and modulate target gene expression . Positive_regulation RELA TNF 11983688 954130 It also inhibited the *induced* DNA binding of nuclear [NF-kappaB] but not the phosphorylation and degradation of IkappaB . Positive_regulation RELA TNF 11986318 961669 Indirect immunofluorescence shows that E7 impairs *induced* nuclear translocation of NF-kappaB , thus preventing [NF-kappaB] from binding to its cognate DNA . Positive_regulation RELA TNF 11991856 938593 These acute-alcohol induced changes in monocytic cells were different compared to T lymphocytes , both in Jurkat CD4 cells and peripheral human T cells , acute alcohol had a biphasic effect on induced [NF-kappa B] *activation* via an I-kappa B alpha dependent mechanism . Positive_regulation RELA TNF 11991979 938648 We demonstrate here that the E3 region of Ad inhibits the activation of [NF-kappa B] *induced* by and interleukin-1 . Positive_regulation RELA TNF 12003776 939877 Enalapril protects mice from pulmonary hypertension by inhibiting *mediated* activation of [NF-kappaB] and AP-1 . Positive_regulation RELA TNF 12007574 940594 In contrast to , which *activates* [NF-kappaB] in minutes , NF-kappaB activation induced by anticancer drugs usually occurred more than 1hr after stimulation . Positive_regulation RELA TNF 12010810 941313 In this study , alone *induced* [NF-kappaB] nuclear translocation , cIAP-1 and cIAP-2 up-regulation , and MM cell proliferation ; Positive_regulation RELA TNF 12010810 941316 Moreover , SN50 inhibited *induced* expression of another [NF-kappaB] target gene , intercellular adhesion molecule-1 . Positive_regulation RELA TNF 12021482 943214 Western blot analysis revealed that TNF-alpha caused degradation of I kappa B alpha within 10 min. EMSA demonstrated that *led* to increased DNA binding activity of [NF kappa B] and that proteasome inhibitors counteracted NF kappa B activation . Positive_regulation RELA TNF 12023051 943496 Electrophoretic mobility shift assay revealed that H2O2 enhanced *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 12023343 943733 However , [NF-kappaB] activation *induced* by could be sustained by blocking autocrine IL-10 . Positive_regulation RELA TNF 12023359 943742 Induction of macrophage-inflammatory protein-3alpha gene expression by dependent [NF-kappaB] *activation* . Positive_regulation RELA TNF 12032830 948136 Therefore , MnSOD expression is induced by [NF-kappaB] in epithelial cancer cells in *response* to , and is at least partially responsible for their resistance to TNF-alpha induced apoptosis , presumably through the clearance of death inducing ROS . Positive_regulation RELA TNF 12052823 968766 On the other hand mediated [NF-kappa B] *activation* is not reduced by the phosphoinositide-3 kinase inhibitors wortmannin and LY294002 , although these inhibitors completely block the activation of Akt . Positive_regulation RELA TNF 12055072 951608 Inhibition of either PKC-delta or PI 3-kinase attenuated mediated *activation* of the antiapoptotic transcription factor [NFkappaB] . Positive_regulation RELA TNF 12055104 951693 Interleukin (IL)-1beta- and induced [NF-kappaB] *activation* and kappaB dependent gene expression are inhibited in HeLa cells but not in Ad5dnNIK infected HT-29 cells . Positive_regulation RELA TNF 12060665 975675 Ectopic expression of protein-tyrosine kinase Bcr-Abl suppresses *induced* [NF-kappa B] activation and IkappaBalpha phosphorylation . Positive_regulation RELA TNF 12060665 975677 We used a bcr-abl-deficient human megakaryocytic leukemia cell line MO7E and an isogenic MBA cell line stably transfected with bcr-abl. Electrophoretic mobility shift assay revealed that *activated* the nuclear transcription factor [NF-kappaB] in MO7E cells but not in MBA cells . Positive_regulation RELA TNF 12060665 975694 The suppression of *induced* [NF-kappaB] activation by Bcr-Abl was not restricted to MBA cells , because ectopic expression of Bcr-Abl in human acute myeloid leukemia HL-60 cells also blocked TNF induced NF-kappaB activation . Positive_regulation RELA TNF 12060857 952847 Furthermore , somatostatin suppressed *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 12065308 954340 Role of glycogen synthase kinase-3 in induced [NF-kappaB] *activation* and apoptosis in hepatocytes . Positive_regulation RELA TNF 12065308 954342 In this study , we determined the role of GSK-3 in induced [NF-kappaB] *activation* and cell death in primary hepatocytes . Positive_regulation RELA TNF 12065326 954378 Because Gab1 is involved in both c-Jun and [NF-kappaB] *activation* by , we focused on Gab1 dependent signaling . Positive_regulation RELA TNF 12065326 954395 Gab1 associated with MEKK3 , and a catalytically inactive form of MEKK3 inhibited *induced* c-Jun and [NF-kappaB] transcriptional activation , suggesting a critical role for Gab1 and MEKK3 in TNF-alpha signaling . Positive_regulation RELA TNF 12065710 954671 Silymarin also inhibited *induced* [NF-kappaB/Rel] activation , whereas okadaic acid induced NF-kappaB/Rel activation was not affected . Positive_regulation RELA TNF 12065913 954837 We examined whether or not theophylline inhibits induced *activation* of the nuclear transcription factor [NF-kappaB] , a factor that is essential for the expression of proinflammatory cytokines , in human monocytic U-937 cells , a T cell line ( Jurkat ) and peripheral blood mononuclear cells ( PBMC ) . Positive_regulation RELA TNF 12065913 954839 The inhibitory effect of theophylline on induced [NF-kappaB] *activation* was evaluated by Western blotting , flow cytometry and chloramphenicol acetyltransferase (CAT) assaying . Positive_regulation RELA TNF 12067303 954962 Using EMSA , both MG-132 and NaSal were found to suppress the induced [NF-kappaB] *activation* in eosinophils . Positive_regulation RELA TNF 12080044 976096 The zinc finger protein A20 is a target gene of [NF kappa B] *inducible* by , and it is a potent inhibitor of TNF induced apoptosis . Positive_regulation RELA TNF 12091251 960080 RAW 264.7 macrophages exhibited enhanced TNF-alpha production and NF-kappaB activation in response to silica , whereas IC-21 macrophages did not produce in response to silica and did not *induce* [NF-kappaB] nuclear binding . Positive_regulation RELA TNF 12115190 964093 In addition , cepharanthine suppressed the *stimulated* [NF-kappaB] activity by partly preventing the degradation of IkappaBalpha protein in NS-SV-AC cells . Positive_regulation RELA TNF 12119420 968906 E1A expression did not block upstream events in *induced* activation of [NF-kappa B] in NIH 3T3 cells , including degradation of I kappa B-alpha , nuclear translocation of NF-kappa B subunits , and their dimeric binding to kappa B sequences in the nucleus . Positive_regulation RELA TNF 12131776 966846 IL-1 beta and *increased* the [nuclear factor-kappa B (NF-kappa B)-specific] and activator protein-1-specific DNA binding activity , whereas the NF-IL6 activity was not altered . Positive_regulation RELA TNF 12135603 967388 ANP reduced *induced* [NF-kappaB] activity , which was paralleled by a decreased translocation of p65 to nuclei . Positive_regulation RELA TNF 12135878 967621 *induced* IkappaB phosphorylation and [NFkappaB] activation . Positive_regulation RELA TNF 12137562 997527 Co-transfection with [NF-kappaB] expression vectors or *stimulation* with resulted in significant transactivation of the jfc1 promoter construct , although transactivation of a mutated jfc1 promoter was negligible . Positive_regulation RELA TNF 12138205 969184 This mutated form of Cot also acts as a dominant negative for T-cell antigen receptor/CD28- or Akt/phorbol myristate acetate induced NF-kappa B induction , while having relatively little effect on *induction* of [NF-kappa B] . Positive_regulation RELA TNF 12143039 969600 dependent *activation* of [NF-kappa B] induces the transcription of antiapoptotic genes that renders liver cells resistant against TNF induced apoptosis . Positive_regulation RELA TNF 12154098 997643 In addition , GW4869 did not significantly impair *induced* [NF-kappaB] translocation to nuclei . Positive_regulation RELA TNF 12161520 971961 Electrophoretic mobility shift assay revealed that ( 1 ng/ml ) and phorbol 12-myristate 13-acetate ( TPA ; 0.4 micro M ) , PKC activator , *caused* marked increases in nuclear [NF-kappa B] DNA binding activity . Positive_regulation RELA TNF 12162440 971991 Oxidative stress and *induce* histone acetylation and [NF-kappaB/AP-1] activation in alveolar epithelial cells : potential mechanism in gene transcription in lung inflammation . Positive_regulation RELA TNF 12162440 972002 H2O2 , and , and TSA all *increased* [NF-kappaB] and AP-1 DNA binding to their consensus sites assessed by the electrophoretic mobility shift assay . Positive_regulation RELA TNF 12165487 972841 EMSAs demonstrated that IL-17 did not modulate the *induced* [NF-kappaB] DNA binding activity , but markedly decreased TNF-alpha induced IFN regulatory factor-1 (IRF-1) DNA binding activity . Positive_regulation RELA TNF 12168567 973645 or endotoxin *induce* the activation of two major transcription factors , [NF-kappa B] ( nuclear factor-kappaB ) and AP-1 ( activating protein-1 ) , which in turn induce genes involved in chronic and acute inflammatory responses . Positive_regulation RELA TNF 12176728 975477 NAC decreased induced *activation* of [NF-kappaB] only marginally , indicating that the redox-sensitive component of the inhibition of myogenic differentiation by TNF-alpha occurred independently , or downstream of NF-kappaB . Positive_regulation RELA TNF 12181188 977501 In conclusion , Fe2+ serves as a direct agonist to activate IKK , [NF-kappaB] , and TNF-alpha promoter activity and to *induce* the release of protein by cultured Kupffer cells in a redox status dependent manner . Positive_regulation RELA TNF 12181323 992625 Because the CTAR2 region interacts with the tumor necrosis factor ( TNF-alpha receptor associated death domain protein , it is interesting to find that BRAM1 also interferes with [NF-kappaB] activation *mediated* by . Positive_regulation RELA TNF 12181323 992627 BRAM1 interferes LMP1 mediated and *induced* [NF-kappaB] activation by targeting IkappaBalpha molecules . Positive_regulation RELA TNF 12192035 980759 Here we report that even though NF-kappaB interacts directly with TAF(II)s , *induction* of [NF-kappaB] by does not enhance TFIID recruitment and preinitiation complex formation on some NF-kappaB-responsive promoters . Positive_regulation RELA TNF 12192055 980841 Correspondingly , IKK and [NF-kappaB] *activation* by and , to a lesser extent , IL-1 are reduced . Positive_regulation RELA TNF 12193057 980903 In addition , FK409 diminished basal and *stimulated* [NF-kappa B] activation in ECs . Positive_regulation RELA TNF 12193701 981437 We conclude that SOCS-1 inhibits cytokine induced CD40 expression by blocking IFN-gamma mediated STAT-1alpha activation , which also then results in suppression of IFN-gamma induced secretion and subsequent [NF-kappaB] *activation* . Positive_regulation RELA TNF 12196549 997906 induced activation of the Fas-ligand promoter in IEC *requires* [NF-kappaB] as this was blocked by an I-kappaBalphaM super-repressor and by mutation of an NF-kappaB site in the Fas-ligand promoter . Positive_regulation RELA TNF 12207915 983644 In addition , merlin blocked the *induced* [NF-kappaB-DNA] binding mediated via the inhibition of degradation of IkappaBalpha and blocked the activation of NF-kappaB dependent transcription . Positive_regulation RELA TNF 12208496 983788 Exogenous neutral ( N ) and acidic ( A ) SMase activated NF-kappa B with different kinetics , accounting for the diverse pattern of DNA binding of [NF-kappa B] complexes *activated* by . Positive_regulation RELA TNF 12208496 983792 The predominant *activation* of [RelA] containing kappa B complexes by or NSMase paralleled the induction of interleukin-8 . Positive_regulation RELA TNF 12213594 985543 In order to analyze the role of Rho proteins in *induced* [NF-kappaB-activation] in human umbilical cord vein endothelial cells ( HUVEC ) we used Clostridium difficile toxin B-10463 ( TcdB-10463 ) which inactivates RhoA/Rac1/Cdc42 by glucosylation and Clostridium botulinum C3-toxin which inhibits RhoA/B/C by ADP-ribosylation . Positive_regulation RELA TNF 12213594 985549 Neither 1 microM Rho kinase inhibitor Y-27632 nor microfilament depolymerization by 50 ng/mL C. botulinum C2-toxin blocked *induced* degradation of Ikappa-B , nuclear [NF-kappaB] translocation or expression of a NF-kappaB dependent reporter gene . Positive_regulation RELA TNF 12219013 986613 The 2 groups of mice were analyzed for serum levels of interferon-gamma , , and interleukin-1beta as well as *activation* of [NFkappaB] and STAT1 , 2 proinflammatory transcription factors . Positive_regulation RELA TNF 12225945 987884 Inhibition of JNK signaling also substantially reduced *induced* [NF-kappaB] transactivation , whereas inhibition of ERK and p38 had no effect . Positive_regulation RELA TNF 12244103 1012533 NEMO interacts with a COOH-terminal sequence within both IKKs termed the NEMO binding domain (NBD) , and a cell-permeable NBD peptide blocks NEMO/IKKbeta interactions and inhibits *induced* [NF-kappaB] . Positive_regulation RELA TNF 12244143 990505 family receptors can *lead* to the activation of [NF-kappaB] and this can be a prosurvival signal in some cells . Positive_regulation RELA TNF 12354747 993641 Both LPS and *induced* significant [NFkappaB] activation , cyclooxygenase-2 (COX-2) expression , and inducible NO synthase (iNOS) and cytokine production ; Positive_regulation RELA TNF 12356823 994052 Decreased dissociation could in turn suppress induced *activation* of [NFkappaB] , resulting in declines in expression of IL-1alpha gene and protein . Positive_regulation RELA TNF 12361763 995021 alone can *induce* MCMV IE-1 gene expression and activation of [NFkappaB] and AP-1 in some tissues . Positive_regulation RELA TNF 12361763 995025 We propose that induction of IE-1 gene expression is the first step in reactivation of the virus in an immunocompromised transplant recipient , and that it occurs as a result of the allogeneic response , which induces expression of and subsequent *activation* of [NFkappaB] , and ischemia/reperfusion injury , which induces activation of AP-1 . Positive_regulation RELA TNF 12368351 995405 Here , we demonstrate that TSA ( NaBut ) synergized with both ectopically expressed p50/p65 and *induced* [NF-kappaB] to activate the LTR . Positive_regulation RELA TNF 12372676 996463 Ox-LDL and *increased* the activation of [NF-kappaB] and the preincubation of HUVECs with zofenoprilat , but not with enalaprilat , dose dependently reduced its activation ( P < .001 ) . Positive_regulation RELA TNF 12379212 997091 PLL-g-HA/NF-kappaB31 , but not control oligodeoxynucleotides having a reverse or scrambled sequence , inhibited the intranuclear localization of [NF-kappaB] *induced* by , with almost complete inhibition at 2 .5microg/mL as DNA . Positive_regulation RELA TNF 12380642 997332 Alteration of cytokine release was accompanied by reduced basal and *stimulated* [nuclear factor-kappa B (NF-kappa B)] and activator protein-1 (AP-1) activity . Positive_regulation RELA TNF 12388747 1000286 In contrast to [nuclear factor-kappaB (NF-kappaB)] *activation* by , the specific processes involved in the activation of this transcription factor by ionizing radiation ( IR ) have not been completely defined . Positive_regulation RELA TNF 12390026 1000401 Vitamin C suppresses induced [NF kappa B] *activation* by inhibiting I kappa B alpha phosphorylation . Positive_regulation RELA TNF 12390026 1000409 We found that intracellular vitamin C inhibits induced *activation* of [NFkappaB] in human cell lines ( HeLa , monocytic U937 , myeloid leukemia HL-60 , and breast MCF7 ) and primary endothelial cells ( HUVEC ) in a dose dependent manner . Positive_regulation RELA TNF 12390026 1000411 Vitamin C-loaded cells showed significantly decreased *induced* nuclear translocation of [NFkappaB] , NFkappaB dependent reporter transcription , and IkappaBalpha phosphorylation . Positive_regulation RELA TNF 12395315 1008638 Although con A-induced liver injury depends on both TNFR1 and TNFR2 , dependent iNOS expression is mediated exclusively by TNFR1 and *requires* [NF-kappaB] activation . Positive_regulation RELA TNF 12404274 1009775 The results showed that can *induce* activation of [NF-kappaB] and that the activation and translocation of NF-kappaB into the nucleus is responsible for promoting the 3-D cytomorphologic differentiation of anaplastic thyroid carcinoma cells , which was inhibited by the NF-kappaB translocation inhibitor , NF-kappaB SN50 . Positive_regulation RELA TNF 12404274 1009780 The current data suggest that can *induce* thyrocyte differentiation in anaplastic thyroid carcinoma cells through [NF-kappaB] and that it merits investigation as differentiation therapy for the treatment of patients with anaplastic thyroid carcinoma . Positive_regulation RELA TNF 12411493 1010844 Siah2 efficiently decreases dependent induction of JNK activity and transcriptional *activation* of [NF-kappaB] . Positive_regulation RELA TNF 12431991 1037095 We propose that the biphasic activation of [NF-kappaB] in *response* to may play a key regulatory role in skeletal muscle wasting associated with cachexia . Positive_regulation RELA TNF 12436048 1016123 Our results indicate that acute alcohol inhibits IL-1beta- and *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 12442886 1017121 The designed compound , dehydroxymethyl-epoxyquinomicin ( DHMEQ ) , inhibited the induced *activation* of [NF-kappaB] , and showed an anti-arthritic effect in mice . Positive_regulation RELA TNF 12442886 1017123 DHMEQ inhibited the *induced* cellular DNA binding of nuclear [NF-kappaB] , but not the phosphorylation or degradation of I-kappaB . Positive_regulation RELA TNF 12444159 1017397 Piceatannol inhibits induced [NF-kappaB] *activation* and NF-kappaB mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation . Positive_regulation RELA TNF 12444159 1017399 The treatment of human myeloid cells with piceatannol suppressed *induced* DNA binding activity of [NF-kappaB] . Positive_regulation RELA TNF 12444159 1017401 The effect of piceatannol was not restricted to myeloid cells , as induced [NF-kappaB] *activation* was also suppressed in lymphocyte and epithelial cells . Positive_regulation RELA TNF 12471036 1055493 We found basal binding of p300 , p50/p65 [NF-kappaB] , cyclic AMP regulatory element binding protein-2 , CCAAT/enhancer binding protein beta , and c-Jun. p50/p65 and p300 binding was selectively *increased* by . Positive_regulation RELA TNF 12480916 1024253 Of interest , *induced* persistent [nuclear factor-kappaB (NF-kappaB)-DNA] binding activity even in the presence of SNP , mirroring apoptosis protection effects . Positive_regulation RELA TNF 12481431 1024296 Sodium selenite and MeSeA , at the concentrations that induced apoptosis , inhibited [NF-kappa B] DNA binding *induced* by and lipopolysaccharide in DU145 and JCA1 prostate cells . Positive_regulation RELA TNF 12508545 1027483 2. TPCK could inhibit the activation of [NF-kappa B] *induced* by . Positive_regulation RELA TNF 12509469 1038724 Down regulation of endogenous RFC ( p140 ) inhibits expression from a chromosomally integrated reporter plasmid induced by endogenous , *activated* [NF-kappaB] . Positive_regulation RELA TNF 12509805 1038774 Finally , IL-1beta and *induced* degradation of NF-kappaB 's bound inhibitory protein , IkappaB-alpha , leading to translocation of [NF-kappaB] into the nucleus . Positive_regulation RELA TNF 12511413 1079076 The treatment of RAW264 cells with TSA and NaB inhibited *induced* nuclear translocation of [NF-kappa B] and sRANKL induced activation of p38 mitogen activated protein kinase (MAPK) signals . Positive_regulation RELA TNF 12512958 1027732 Expression of the p75 TNF receptor is linked to *induced* [NFkappaB] translocation and oxyradical neutralization in glial cells . Positive_regulation RELA TNF 12517920 1071014 IBOP abrogated induced [NFkappaB] *activation* in endothelial cells , as determined by reduced IkappaB phosphorylation and NFkappaB nuclear translocation , by inhibiting the assembly of signaling intermediates with the intracellular domain of TNF receptors 1 and 2 in response to TNFalpha . Positive_regulation RELA TNF 12526096 1028240 To understand such conflicting effect of oxidative stress on NF- kappakB activation , HeLa cells were incubated with H ( 2 ) O ( 2 ) or diamide and *induced* expression of [NF-kappaB] reporter gene was measured . Positive_regulation RELA TNF 12527815 1048504 This study shows that AEA inhibits *induced* [NF-kappaB] activation by direct inhibition of the IkappaB kinase (IKK)beta and , to a lesser extent , the IKKalpha subunits of kappaB inhibitor ( IkappaB) kinase complex , and that IKKs inhibition by AEA correlates with inhibition of IkappaBalpha degradation , NF-kappaB binding to DNA , and NF-kappaB dependent transcription in TNFalpha stimulated cells . Positive_regulation RELA TNF 12531807 1079130 Delta TRAF6 and Delta MyD88 significantly abrogate antibody induced as well as IL-1- or LPS induced NF-kappa B activation , whereas Delta TRAF2 ( involved in [NF-kappa B] *activation* by ) does not affect it . Positive_regulation RELA TNF 12555061 1051599 In this study , the basal and *induced* activation of [NF-kappaB] has been examined in cells overexpressing H-Ras , K-Ras or N-Ras . Positive_regulation RELA TNF 12556975 1051797 *Activation* of [NF-kappaB] by prior to TRAIL exposure increased resistance of the cells to TRAIL mediated apoptosis . Positive_regulation RELA TNF 12573143 1029609 Additionally , *induced* activation of [NF-kappaB] and AP-1 observed in ML-1a was greatly reduced in clone 19 . Positive_regulation RELA TNF 12573143 1029612 These results indicate that mitochondrial respiratory function regulates induced and constitutive *activation* of [NF-kappaB] and AP-1 . Positive_regulation RELA TNF 12574206 1057809 We hypothesize that may *induce* IL-8 production in endometriotic cells through [nuclear factor-kappa B (NF-kappa B)] activation . Positive_regulation RELA TNF 12574206 1057815 The current study showed for the first time that GnRHa treatment attenuated the expression of IL-8 by reducing induced [NF-kappa B] *activation* . Positive_regulation RELA TNF 12586352 1059020 Among others , the NF-kappa B-dependent zinc finger protein A20 is involved in the negative feedback regulation of [NF-kappa B] activation in *response* to . Positive_regulation RELA TNF 12586352 1059026 We previously demonstrated that A20 can interact with A20 binding inhibitors of NF-kappa B activation ( ABINs ) , which have the potential to inhibit *induced* activation of [NF-kappa B] upon overexpression . Positive_regulation RELA TNF 12586603 1059344 Moreover , bezafibrate repressed *induced* DNA binding activity of [NF-kappaB] . Positive_regulation RELA TNF 12586603 1059346 Thus , fibrates reduced induced [NF-kappaB] *activation* and RANTES expression , possibly suggesting that fibrates might be inhibitory agents of migration of inflammatory cells by RANTES to the liver in patients with alcoholic liver diseases . Positive_regulation RELA TNF 12592100 1029793 Activation is dose dependent and peaked at 30 min. Doses of Pefabloc sufficient to inhibit trypsin activation reduced CCK induced activation of NF-kappaB whereas induced [NF-kappaB] *activation* was not blocked but slightly increased . Positive_regulation RELA TNF 12595760 1061713 An LKB1 interacting protein negatively regulates induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 12604244 1062592 Stimulation with *led* to the activation of the transcription factor [NF-kappaB] and enhanced VSMC growth . Positive_regulation RELA TNF 12606638 1079735 Ad.N17Rac1 did not inhibit induced *activation* of [nuclear factor-kappaB (NF-kappaB)] binding activity or inhibitor of NF-kappaB-alpha degradation . Positive_regulation RELA TNF 12606947 1062994 The treatment of these cells with adenosine suppressed induced [NF-kappaB] *activation* , but had no effect on activation of another redox-sensitive transcription factor , AP-1 . Positive_regulation RELA TNF 12606947 1062996 The effect on induced [NF-kappaB] *activation* was selective as adenosine had minimal effect on NF-kappaB activation induced by H ( 2 ) O ( 2 ) , PMA , LPS , okadaic acid , or ceramide , suggesting differences in the pathway leading to NF-kappaB activation by different agents . Positive_regulation RELA TNF 12606947 1062999 The suppression of induced [NF-kappaB] *activation* by adenosine was found not to be because of inhibition of TNF induced IkappaBalpha phosphorylation and degradation or IkappaBalpha kinase activation . Positive_regulation RELA TNF 12606947 1063001 The suppression of induced [NF-kappaB] *activation* was unique to adenosine , as neither its metabolites ( inosine , AMP , and ATP ) nor pyrimidines ( thymidine and uridine ) had any effect . Positive_regulation RELA TNF 12606947 1063003 Overall , our results clearly demonstrate that adenosine selectively suppresses *induced* [NF-kappaB] activation , which may contribute to its role in suppression of inflammation and of the immune system . Positive_regulation RELA TNF 12627504 1066926 Sulindac inhibited mediated [NF-kappaB] *activation* and greatly sensitized MKN45 and HeLa cell lines to TNF-alpha . Positive_regulation RELA TNF 12631113 1067605 The incubation of MCs with MG132 , a NF-kappaB inhibitor , abolished *induced* degradation of inhibitory protein of NF-kappaB ( I-kappaB)alpha , nuclear translocation of [NF-kappaB] , and fractalkine expression , without affecting phospho-c-Jun levels . Positive_regulation RELA TNF 12631113 1067625 Additional experiments examining the role of cAMP on MC fractalkine expression showed that the incubation of MCs with TNF-alpha and either db-cAMP or forskolin attenuated TNF-alpha stimulated fractalkine mRNA and protein expression , preceded by attenuation of *activated* phosphorylation of p42/44 MAPK , and c-Jun , but not phosphorylation of PKCzeta/iota or nuclear translocation of [NF-kappaB] . Positive_regulation RELA TNF 12635574 1068511 Our results indicated that production was *induced* by D. farinae in PBMCs of patients with atopic asthma by the activation of [NF-kappa B] via CD23 . Positive_regulation RELA TNF 12637573 1091956 We have shown previously that strongly *induces* osteoclastogenesis of preosteoclasts and do so through activation of the transcription factor , [NF-kappaB] . Positive_regulation RELA TNF 12646250 1069981 Ergothioneine inhibits oxidative stress- and *induced* [NF-kappa B] activation and interleukin-8 release in alveolar epithelial cells . Positive_regulation RELA TNF 12646250 1069984 The aim of this study was to determine whether ergothioneine can inhibit the hydrogen peroxide ( H ( 2 ) O ( 2 ) ) - and *mediated* activation of [NF-kappa B] and the release of IL-8 in human alveolar epithelial cells ( A549 ) . Positive_regulation RELA TNF 12646250 1069986 Ergothioneine inhibited both H ( 2 ) O ( 2 ) - and mediated *activation* of [NF-kappa B] . Positive_regulation RELA TNF 12663241 1074458 clearly *up-regulated* RANTES expression in a time dependent fashion and induced DNA binding activity of [NF-kappaB] . Positive_regulation RELA TNF 12665478 1074756 hALX transfected HEK293 cells transmitted LXA4 signals that inhibit induced [NFkappaB] *activation* . Positive_regulation RELA TNF 12692090 1093276 Only at high concentrations , cPG enhanced TNF-alpha induced cell death and inhibited *induced* IkappaB-alpha kinase (IKK) activation , IkappaB-alpha degradation , and [NF-kappaB/p65] translocation , while promoting AP-1/c-jun phosphorylation . Positive_regulation RELA TNF 12699902 1081663 We demonstrate in both cell types that TNF-alpha activates NF-kappaB , and HQ exposure inhibits *activation* of [NF-kappaB] by in a dose dependent manner . Positive_regulation RELA TNF 12704649 1082363 In analogy with *dependent* activation of [NFkappaB] , treatment with either the anti-oxidant N-acetyl cysteine (NAC) or the cyclooxygenase (COX) inhibitor acetyl salicylic acid ( aspirin ) , but not indometacin , prevents the induction of NFkappaB dependent transcription by AII . Positive_regulation RELA TNF 12706288 1082584 Moreover , , a secretory product of round spermatids , *stimulated* [NF-kappaB] binding to the AR promoter , induced AR promoter activity , and increased endogenous AR expression in primary cultures of Sertoli cells . Positive_regulation RELA TNF 12706343 1082635 Activation of [NF-kappaB] in *response* to was intact in both cell lines . Positive_regulation RELA TNF 12709429 1112681 The *role* of receptor associated factor ( TRAF)-1 in [NF-kappaB] activation by various members of the TNF receptor family is not well understood , and conflicting data have been published . Positive_regulation RELA TNF 12709443 1100428 Using various deficient mouse embryonic fibroblast cells , we have compared the signaling pathways leading to [NF-kappaB] induction in *response* to and LTbetaR activation . Positive_regulation RELA TNF 12712434 1083434 The *activation* of [NF-kappaB] through ligand induced stimulation by or phorbol 12-myristate 13-acetate ( PMA ) was also inhibited by transient expression of LDOC1 in a dose dependent manner . Positive_regulation RELA TNF 12713738 1083480 SOCS-3 did not induce any alterations in [NF-kappaB] activity *induced* by LPS or . Positive_regulation RELA TNF 12716675 1083753 The nuclear appearance of p50-NFkappaB and [p65-NFkappaB] acutely *induced* by was not modified by resveratrol but was increased after overnight incubation with resveratrol alone or in combination with TNF-alpha . Positive_regulation RELA TNF 12716741 1083758 Strong T1D protection mediated at the beta-cell level characterized DL704/NOD mice lacking the E3 gp19K gene suppressing MHC class I expression but retaining the 10.4K , 14.5K , and 14.7K genes inhibiting Fas- or TNF-alpha induced apoptosis and *induced* [NF-kB] activation . Positive_regulation RELA TNF 12716748 1083761 Recent studies incriminating tumor necrosis factor (TNF)-alpha as the final effector in pancreatic beta-cell death in type 1 diabetes underscore the potential role of dependent [NF-kappaB] *activation* as an important modulator of pancreatic beta-cell death in autoimmune diabetes . Positive_regulation RELA TNF 12716748 1083765 The [NF-kappaB] DNA binding nuclear complex *activated* by contained both the p65 and p50 subunit . Positive_regulation RELA TNF 12716748 1083767 IFN-gamma pretreatment did not affect induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 12717418 1083865 This DNA binding activity consisted primarily of RelB-p50 heterodimers , which was distinct from the [NF-kappa B] *activation* of . Positive_regulation RELA TNF 12721308 1106522 TRADD also binds two other adaptors receptor interacting protein ( RIP ) and TNF-receptor associated factor 2 (TRAF2) , which are required for *induced* [NF-kappaB] and c-Jun N-terminal kinase activation , respectively . Positive_regulation RELA TNF 12729461 1106715 *activated* [nuclear factor kappaB (NF-kappaB)] and induced fractalkine and CX3CR1 expression in a time dependent manner in rat aortic SMCs . Positive_regulation RELA TNF 12729461 1106731 Taken together , our results demonstrate that induces the expression of fractalkine and CX3CR1 in rat aortic SMCs and that this induction is *mediated* by [NF-kappaB] activation . Positive_regulation RELA TNF 12744771 1088521 U937 membranes , as well as IL-1beta and , *induced* nuclear translocation of [NF-kappaB] . Positive_regulation RELA TNF 12748169 1113003 We demonstrate a critical role for FAK in the induced *activation* of [nuclear factor (NF)-kappaB] , using FAK-deficient ( FAK-/- ) embryonic fibroblasts . Positive_regulation RELA TNF 12748169 1113009 Of note , *induced* [NF-kappaB] DNA binding activity and activation of IkappaB kinases ( IKKs ) were markedly impaired in FAK-/- cells , whereas the expression of TNF receptor I or other signaling molecules such as receptor interacting protein ( RIP ) , tumor necrosis factor receptor associated factor 2 ( TRAF2 ) , IKKalpha , IKKbeta , and IKKgamma was unchanged . Positive_regulation RELA TNF 12748303 1089047 induced *activation* of [NF-kappaB] is accelerated in SODD-deficient cells , but TNF induced c-Jun N-terminal kinase activity is slightly repressed . Positive_regulation RELA TNF 12753742 1090335 Recruitment of TNF receptor 1 to lipid rafts is essential for mediated [NF-kappaB] *activation* . Positive_regulation RELA TNF 12761333 1091495 Both of these agents also reduced the activation of [NF-kappaB] *induced* by LPS , and interleukin-1beta in smooth muscle cells . Positive_regulation RELA TNF 12761580 1091673 Immunostaining and EMSA revealed that [NF-kappaB] was *activated* strongly by compared to TNF alone in a human colon adenocarcinoma cell line , RPMI4788 . Positive_regulation RELA TNF 12761580 1091679 On the other hand , Fas expression was strongly enhanced by TNF/IFN-alpha , and inhibition of induced [NF-kappaB] *activation* , by using NF-kappaB decoy , decreased Fas expression . Positive_regulation RELA TNF 12767906 1094469 Indeed , TNF alpha induced NF-kappa B translocation was not sufficient to support enhancement of the transcription and des-IGF-1 did not promote but partly inhibited both the induced [NF-kappa B] *activation* and I kappa B alpha degradation through a PI-3K dependent pathway . Positive_regulation RELA TNF 12773487 1095117 [NF-kappaB] binding to this sequence is *increased* by stimulation . Positive_regulation RELA TNF 12775719 1119757 In transfection experiments , the CARD6 protein suppressed NF-kappa B induction by Nod1 or Cardiak but did not interfere with [NF-kappa B] *activation* by the CARD containing adapter protein Bcl10 or the cytokine , demonstrating specificity of CARD6 for Nod-1 and Cardiak dependent pathways . Positive_regulation RELA TNF 12783888 1113514 In HEK293 cells , where can *activate* [NF-kappa B] , SNP likewise suppresses the binding of the active NF-kappa B complex , restoring the binding of the repressive p50/p50 homodimer complex . Positive_regulation RELA TNF 12791476 1097688 We tested the hypothesis that fosfomycin inhibits the activation of [NF-kappaB] *induced* by in human monocytic U-937 cells , and a T cell line ( Jurkat ) . Positive_regulation RELA TNF 12795658 1098442 Glimepiride dose dependent inhibition of carboxymethyllysin ( CML ) albumin or and H2O2 induced *activation* of [NF-kappaB] binding were determined , using isolated peripheral blood mononuclear cells from healthy volunteers , and transcriptional activity of bovine aortic endothelial cells either left untreated or induced with CML albumin incubated with or without glimepiride . Positive_regulation RELA TNF 12801316 1101075 We examined whether or not pranlukast inhibits induced *activation* of nuclear transcription factor [NF-kappa B] , a factor that is essential for the expression of proinflammatory cytokines , on human monocytic 1.3 % dimethylsulphoxide ( DMSO ) -differentiated U-937 cells , which have cysteinyl LT1 (CysLT1) receptors on their membranes , and T cells ( Jurkat ) , which do not . Positive_regulation RELA TNF 12801316 1101077 The inhibitory effects of pranlukast and MK-571 , which is an LTD4 receptor-selective antagonist , on induced [NF-kappa B] *activation* was evaluated by Western blotting and flow cytometry , and those on lipopolysaccharide (LPS) induced interleukin-6 (IL-6) production in peripheral blood mononuclear cells ( PBMC ) were evaluated by enzyme linked immunosorbent assaying . Positive_regulation RELA TNF 12810884 1102860 Mutation of the TATA box had no effect on or RelA/p65 mediated *induction* of [NFkappaB-responsive] promoters , indicating a specific st-ag effect on hTAF ( II ) 130/135 . Positive_regulation RELA TNF 12815168 1103429 Namely , JD inhibits induced *activation* of [NF-kappaB] in mouse 3T3 and human HeLa cells . Positive_regulation RELA TNF 12816868 1140928 Although expression of mutant IkappaBalpha inhibited the *induced* [NF-kappaB] response , it had no effect on tumor growth in mice . Positive_regulation RELA TNF 12851413 1134883 Oncoprotein suppression of induced [NF kappa B] *activation* is independent of Raf controlled pathways . Positive_regulation RELA TNF 12851413 1134914 This suppression of NF kappa B is manifested by an inhibition of TNF induced inhibitor of NF kappa B ( IKK ) activity and NF kappa B DNA binding potential but not by blocking *induced* nuclear accumulation of [NF kappa B/p65] . Positive_regulation RELA TNF 12851485 1109623 c-Myc and E2F1 inhibit [NF-kappaB] activities *induced* by or reactive oxygen species . Positive_regulation RELA TNF 12859994 1111167 Since [nuclear factor-kappaB (NF-kappaB)] is *activated* by and induces expression of prosurvival genes , effects of the antisense oligodeoxynucleotides to NF-kappaB subunits , p65 and p50 , were examined . Positive_regulation RELA TNF 12861043 1111703 Furthermore , cFLIP over-expression activated nuclear factor (NF)-kappaB and cFLIP down-regulation attenuated [NF-kappaB] activation *induced* by or TRAIL . Positive_regulation RELA TNF 12867288 1112061 The [NF-kappaB] activation *induced* by MoCM and were inhibited by Se at the physiological levels . Positive_regulation RELA TNF 12867288 1112065 The maximum activation of [NF-kappaB] was *induced* by or MoCM at a Se concentration ( 0.5 approximately 1 micromol/l ) which was half the level of the serum Se in healthy subjects and was equivalent to level in subjects with pathological conditions together with high serum CRP values . Positive_regulation RELA TNF 12867425 1141849 A role for NF-kappaB essential modifier/IkappaB kinase-gamma ( NEMO/IKKgamma ) ubiquitination in the *activation* of the [IkappaB kinase complex] by . Positive_regulation RELA TNF 12882985 1142762 Absence of apolipoprotein J causes reduction of IkappaB stability , a *dependent* increase in [NF-kappaB] activity , increased transcription of the NF-kappaB target gene c-IAP and down-modulation of p53 protein . Positive_regulation RELA TNF 12885939 1116817 Moreover , [NF-kappaB] nuclear translocation *induced* by TRAIL but not by was abrogated by z-IETD-fmk , a caspase-8-specific inhibitor . Positive_regulation RELA TNF 12890427 1117262 At the molecular level , EXPLY-37 did not inhibit the *activation* of the [nuclear factor kappa B (NF-kappaB)] transcription factor by . Positive_regulation RELA TNF 12897154 1118429 Although TRAF2 is known to be required for *induced* JNK and [NF-kappaB] activation , the underlying mechanism of the increased sensitivity of TRAF2 null cells ( TRAF2 ( -/- ) ) to TNF induced apoptosis is not fully understood . Positive_regulation RELA TNF 12900338 1121099 Infection of cardiomyocytes with an adenoviral vector ( Ad ) encoding A20 inhibited *stimulated* [NF-kappaB] signaling with an efficacy comparable to dominant negative inhibitor of kappa-B kinase beta ( dnIKKbeta ) . Positive_regulation RELA TNF 12912861 1129499 and aims : *induction* of [nuclear factor kappaB (NFkappaB)] activation plays a major role in the pathogenesis of inflammatory bowel disease (IBD) . Positive_regulation RELA TNF 12917341 1130561 Potentiation of induced [NF-kappa B] *activation* by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I kappa B alpha . Positive_regulation RELA TNF 12917341 1130563 Here , we show that inhibitors of deacetylases such as trichostatin A (TSA) and sodium butyrate ( NaBut ) potentiated *induced* expression of several natural [NF-kappa B-driven] promoters . Positive_regulation RELA TNF 12917341 1130565 Importantly , TSA prolonged both *induced* DNA binding activity and the presence of [NF-kappa B] in the nucleus . Positive_regulation RELA TNF 12917420 1157670 Remarkably , we found that *activation* of [NF-kappaB] by selectively inhibited TCDD induced serine 2 phosphorylation in mouse liver cells , suggesting that residue-specific phosphorylation of RNA PII CTD at the cyp1a1 promoter is an important regulatory point upon which signal `` cross-talk '' converges . Positive_regulation RELA TNF 12934647 1132836 IL-1beta and can *induce* extracellular signal regulated kinase ( ERK ) , IKK , IkappaB degradation and [NF-kappaB] activation . Positive_regulation RELA TNF 12935892 1132874 Moreover , silymarin suppressed the *induced* DNA binding of [NF-kappaB/Rel] in HUVECs . Positive_regulation RELA TNF 12941924 1133643 MCMV infection blocked *induced* nuclear translocation of [NF-kappaB] . Positive_regulation RELA TNF 12947019 1151621 Because MEKK3 and Gab1 are critical for *induced* c-Jun and [NF-kappaB] activation , we determined the role of SHP-2 phosphatase activity in MEKK3 signaling . Positive_regulation RELA TNF 12960255 1158296 To investigate a potential interplay between induced *activation* of p38 MAPK and [NF-kappaB] , the p38 MAPK inhibitor SB203580 and a dominant negative p38 MAPK mutant were used . Positive_regulation RELA TNF 12960358 1138464 BA suppressed [NF-kappaB] activation *induced* by , PMA , cigarette smoke , okadaic acid , IL-1 , and H ( 2 ) O ( 2 ) . Positive_regulation RELA TNF 1315830 185513 Inhibition of mediated [NF-kappa B] *activation* by selective blockade of the human 55-kDa TNF receptor . Positive_regulation RELA TNF 1320006 190078 *activated* [NF-kappa B] , a nuclear factor thought to mediate multiple actions of TNF-alpha , in these cells with a maximum effect observed after 30 min of treatment . Positive_regulation RELA TNF 13679039 1140202 Identification of a novel serine/threonine kinase that inhibits *induced* [NF-kappaB] activation and p53 induced transcription . Positive_regulation RELA TNF 1431113 202793 These observations suggest that and PMA do not *lead* to [NF-kappa B] activation through induction of changes in the cell redox status . Positive_regulation RELA TNF 14515147 1147029 In the SH-SY5Y cell line , neither *activated* [NFkappaB] nor induced MnSOD expression and activity , but was capable of modulating the IL-1 effects . Positive_regulation RELA TNF 14522944 1148262 Previously , we demonstrated that [NF-kappaB] controls *mediated* suppression of myogenesis through a mechanism involving MyoD mRNA down-regulation . Positive_regulation RELA TNF 14530285 1174845 , which *activates* both [NF-kappa B] and AP-1 , increased MAT2A expression in a dose- and time dependent manner , binding of both NF-kappa B and AP-1 to the MAT2A promoter and MAT2A promoter activity , with the latter effect blocked by site directed mutagenesis of the NF-kappa B and AP-1 binding sites . Positive_regulation RELA TNF 14530285 1174848 Although blocking NF-kappa B had no influence on the ability of TNF alpha to increase AP-1 nuclear binding , blocking AP-1 with dominant negative c-Jun prevented the mediated *increase* in [NF-kappa B] binding . Positive_regulation RELA TNF 14530343 1149248 We previously found that IL-4 and cooperate in the *activation* of STAT6 and [NF-kappaB] , suggesting that these transcription factors are regulated by common intracellular signaling pathways . Positive_regulation RELA TNF 14532979 1152287 In the course of our screening for tumor necrosis factor-alpha (TNF-alpha) function inhibitors , conophylline , a vinca alkaloid isolated from the plant Ervatamia microphylla , was found to inhibit induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 14532979 1152289 We studied the effect of conophylline on *induced* [NF-kappaB] and JNK activations in human T-cell leukemia Jurkat cells . Positive_regulation RELA TNF 14557256 1185996 receptor associated factor ( TRAF) 1 *regulates* CD40 induced TRAF2 mediated [NF-kappaB] activation . Positive_regulation RELA TNF 14561767 1186191 Beta-catenin was translocated into the nucleus , whereas the *induced* nuclear translocation of [NFkappaB] was impaired . Positive_regulation RELA TNF 14565866 1154981 The main transcript , which is ubiquitously expressed , encodes a protein that binds tumor necrosis factor receptor 1 ( TNF-R1 ) and downregulates induced *activation* of [NF-kappaB] . Positive_regulation RELA TNF 14566965 1155101 In both prechondrocytes and articular chondrocytes , *induced* concentration dependent activation of MEK1/2 and [NF-kappaB] , but not p38 or JNK . Positive_regulation RELA TNF 14572618 1155844 In contrast , either the proteasome inhibitor carbobenzoxy-L-leucy-L-leucy-L-leucinal ( MG 132 ) or the IkappaBalpha inhibitor BAY 11-7082 ablated TNFalpha induced ICAM-1 gene expression and MG132 inhibited *induced* [NFkappaB] complexes . Positive_regulation RELA TNF 14576080 1199903 Expression of N17Rac1 inhibited *induced* MCP-1 and [NF-kappaB] transcriptional activity . Positive_regulation RELA TNF 14578185 1156658 NGF regulates nuclear factor (NF)-kappaB activity , reducing p50/p65 binding detected by electromobility shift assay and reduced NF-kappaB CAT reporter activities from both basal unstimulated levels and after [NF-kappaB] *induction* by . Positive_regulation RELA TNF 14580690 1156973 Pretreating MKN45 cells with hyperthermia ( 42.0 degrees C ) significantly inhibited the *induced* increase in the binding activity of [NF-kappaB] to DNA . Positive_regulation RELA TNF 14580690 1156975 This study suggests that hyperthermia can inhibit the induced [NF-kappaB] *activation* and that hyperthermia renders human gastric cancer cells susceptible to the TNF-alpha induced apoptosis , possibly via inhibition of the NF-kappaB pathway . Positive_regulation RELA TNF 14584040 1187132 Furthermore , the overexpression of TrxR1 enhanced *induced* DNA binding activity of NF-kappa B and [NF-kappa B-dependent] gene expression . Positive_regulation RELA TNF 14584040 1187136 The catalytic Sec residue of TrxR1 , which is essential for reducing Trx , was required for this NF-kappa B activation , and aurothiomalate , an inhibitor of TrxR , suppressed *induced* activation of [NF-kappa B] and the expression of NF-kappa B-targeted proinflammatory genes such as E-selectin and cyclooxygenase-2 . Positive_regulation RELA TNF 14585846 1187155 This study investigated the significance of PI 3-kinase/Akt signaling to induced [NF-kappa B] *activation* in transformed , immortalized , and primary cells . Positive_regulation RELA TNF 14585846 1187158 Pharmacological inhibition of PI 3-kinase blocked *induced* [NF-kappa B] DNA binding in the 293 line of embryonic kidney cells , partially affected binding in MCF-7 breast cancer cells , HeLa and ME-180 cervical carcinoma cells , and NIH 3T3 cells but was without significant effect in H1299 and human umbilical vein endothelial cells , cell types in which TNF activated Akt . Positive_regulation RELA TNF 14599550 1161285 Furthermore , treatment of cells with these compounds prevented the *induced* expression of anti-apoptotic [NF-kappaB] target genes Bfl-1/A1 , a prosurvival Bcl-2 homologue , and resulted in sensitizing HT-1080 cells to TNF-alpha induced cell death . Positive_regulation RELA TNF 14600157 1187539 [NF-kappaB] activation *induced* by , interleukin-1beta , and lipopolysaccharide was also inhibited by FAF1 overexpression . Positive_regulation RELA TNF 14600158 1200279 Pretreatment of normal human intestinal lamina propria mononuclear cells ( LPMC ) with transforming growth factor-beta1 ( TGF-beta1 ) resulted in a marked suppression of *induced* [NF-kappaB] p65 accumulation in the nucleus , NF-kappaB binding DNA activity , and NF-kappaB dependent gene activation . Positive_regulation RELA TNF 14600158 1200282 In marked contrast , treatment of LPMC from patients with inflammatory bowel disease with TGF-beta1 did not reduce induced [NF-kappaB] *activation* due to the overexpression of Smad7 . Positive_regulation RELA TNF 14603259 1161757 Pharmacological blockade of the IKK2 kinase with AS602868 , a specific inhibitor that competes with ATP binding , prevented induced [NF-kappaB] *activation* in Jurkat leukemic T cells . Positive_regulation RELA TNF 14607843 1200404 Depletion of TRP14 augmented the induced phosphorylation and degradation of I kappa B alpha as well as the consequent *activation* of [NF-kappa B] to a greater extent than did Trx1 depletion . Positive_regulation RELA TNF 14607933 1162129 dependent *activation* of [NF-kappaB] is stronger in the presence of IFN-gamma . Positive_regulation RELA TNF 14607933 1162136 STAT-1alpha associates with TNFR1 in TNF-alpha treated cells , and this association attenuates mediated [NF-kappaB] *activation* . Positive_regulation RELA TNF 14607933 1162138 We hypothesized that nuclear localization of STAT-1alpha due to IFN-gamma signaling would preclude it from being recruited to the TNFR1 and therefore enhance induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 14607933 1162142 TNF-alpha treatment induces a more robust activation of NF-kappaB in STAT-1alpha-deficient cells , and restoration of STAT-1alpha inhibits dependent [NF-kappaB] *activation* . Positive_regulation RELA TNF 14613935 1187957 In contrast , *activated* [NF-kappaB] both in suspended cells and adherent cells . Positive_regulation RELA TNF 14614151 1165542 A candidate gene in this region is A20 , which is involved in the feedback suppression of [NFkappaB] activation *induced* by . Positive_regulation RELA TNF 14614151 1165544 NFkappaB reporter gene assays showed that this amino acid change results in less effective termination of *stimulated* [NFkappaB] activation by C57BL/6J-A20 . Positive_regulation RELA TNF 14614151 1165547 In accordance , the *induced* expression of [NFkappaB] target genes ( A20 , IkappaBalpha ) in vascular smooth muscle cells was prolonged in cells isolated from C57BL/6J compared with FVB/N mice . Positive_regulation RELA TNF 14617515 1200623 We previously demonstrated that exposing respiratory epithelial cells to 95 % oxygen ( hyperoxia ) synergistically increased *mediated* activation of [NF-kappaB] and NF-kappaB dependent gene expression by a mechanism involving increased activation of IkappaB kinase (IKK) . Positive_regulation RELA TNF 14630924 1201126 [NF-kappaB] reporter activity *induced* by receptor 1 , TNF receptor associated death domain , TNF receptor associated factor-2 , NF-kappaB inducing kinase , and IkappaBalpha kinase , were all blocked by flavopiridol but not that activated by p65 . Positive_regulation RELA TNF 14633987 1170873 Cotransfection of siRNAs directed against both TAB2 and TAB3 inhibit both IL-1- and *induced* activation of TAK1 and [NF-kappaB] . Positive_regulation RELA TNF 14641910 1183809 Based on these data and on evidence from literature we suggest a model for the potential neurodegenerative effect of NF-kappaB in astroglia : *Activation* of [NF-kappaB] via results in a strongly increased production of MCP-1 . Positive_regulation RELA TNF 14646384 1173133 Azelastine inhibits secretion of IL-6 , and IL-8 as well as [NF-kappaB] *activation* and intracellular calcium ion levels in normal human mast cells . Positive_regulation RELA TNF 14656710 1210482 In contrast , markedly *increased* activation of [NF-kappaB] in both normal and Crohn 's cells . Positive_regulation RELA TNF 14662828 1177602 Transfection of full-length CIAS1 or either of two shorter , naturally occurring isoforms dramatically inhibited *induced* activation of [NF-kappaB] reporter activity . Positive_regulation RELA TNF 14662866 1177647 activation of NF-kappaB , in contrast , did not *increase* NGAL synthesis , even though induced binding of [NF-kappaB] to the NGAL promoter was observed in vitro . Positive_regulation RELA TNF 14674885 1211098 The introduction of calcium into HEK293 cells either through the activation of muscarinic cholinergic receptors or through the application of the ionophore A23187 was found to enhance dependent *activation* of [NF-kappaB] . Positive_regulation RELA TNF 14676304 1178944 Because TRIP is an inhibitor of [nuclear factor (NF)-kappaB] *activation* by , the effect of CYLD on NF-kappaB activation was investigated in HeLa cells . Positive_regulation RELA TNF 14684844 1211418 Moreover , we demonstrated that AT(2) receptor stimulation attenuated mediated [NF-kappaB] *activation* and MCP-1 expression . Positive_regulation RELA TNF 14711835 1225497 We have identified two peptides from the p65 subunit of NF-kappaB ( P1 and P6 were from amino acid residues 271-282 and 525-537 , respectively ) that , when linked with a PTD derived from the third helix sequence of antennapedia , inhibited induced [NF-kappaB] *activation* in vivo . Positive_regulation RELA TNF 14713911 1197168 Similarly , pNHP ( 73-102 ) decreased induced [NFkappaB] *activation* in NHBE cells . Positive_regulation RELA TNF 14713952 1202643 Here , we demonstrate that TRAF2 ubiquitination is required for induced *activation* of JNK but not of p38 or [NF-kappaB] . Positive_regulation RELA TNF 14715080 1225547 We observed that *activation* of [NF-kappaB] by ( tumour necrosis factor alpha ) inhibited both basal and androgen stimulated PSA expression , and that this down-regulation occurred at the promoter level , as confirmed by the super-repressor IkappaBalpha ( S32A/S36A ) , a dominant negative inhibitor of NF-kappaB . Positive_regulation RELA TNF 14720501 1197835 Finally , induced activator protein-1 (AP-1) and [nuclear factor-kappaB (NF-kappaB)] *activation* and resultant intracellular adhesion molecule-1 ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) expressions were inhibited by ebselen . Positive_regulation RELA TNF 14729457 1198443 Inhibition of p38 mitogen activated protein kinase reduces *induced* activation of [NF-kappaB] , elicits caspase activity , and enhances cytotoxicity . Positive_regulation RELA TNF 14755547 1205635 Furthermore , the transactivation of *stimulated* [NF-kappaB] and AP-1 was inhibited by U0126 treatment . Positive_regulation RELA TNF 14755547 1205643 Overexpression of RasN17 also abolished the *stimulated* [NF-kappaB] and AP-1 activity . Positive_regulation RELA TNF 14764716 1207358 The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and mediated [NF-kappa B] *activation* through inhibiting phosphorylation of the I-kappa B kinase beta activation loop . Positive_regulation RELA TNF 14764716 1207367 Also , LPS- and *induced* [NF-kappaB] transcription was inhibited by IKKgammaC417R . Positive_regulation RELA TNF 14764716 1207369 Collectively , our results indicated that the zinc finger structure of IKKgamma plays a key role in LPS- and *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 14766535 1207580 Inhibition of induced [NF-kappa B] *activation* by selected NF-kappa B inhibitors , curcumin and triptolide , prevented the increase in Caco-2 TJ permeability , indicating that NF-kappa B activation was required for the TNF-alpha induced increase in Caco-2 TJ permeability . Positive_regulation RELA TNF 14766965 1212048 Furthermore , the *activation* of [NF-kappaB] by TAB3 was blocked by the NF-kappaB inhibitor , SN50 , and by expression of dominant negative forms of alpha associated factor 6 and transforming growth factor beta activated kinase . Positive_regulation RELA TNF 1482376 208238 Incubation of Jurkat T cells ( 1 x 10 ( 6 ) cells/ml ) with a natural thiol antioxidant , alpha-lipoic acid , prior to the stimulation of cells was found to inhibit [NF-kappa B] activation *induced* by ( 25 ng/ml ) or by phorbol 12-myristate 13-acetate ( 50 ng/ml ) . Positive_regulation RELA TNF 14963056 1208753 The effect of eicosapentaenoic acid ( EPA ) , a major n-3 fatty acid in fish oil , on the lipopolysaccharide (LPS) induced expression of and *activation* of [NF-kappaB] were investigated . Positive_regulation RELA TNF 14976147 1243035 Overexpression of the nuclear factor-kappaB (NFkappaB) p50 and/or p65 proteins increased the transcriptional activity of the beta-casein and WAP promoters in HC11 cells , suggesting that the inhibitory effect of on transcription of these genes is not *mediated* by [NFkappaB] . Positive_regulation RELA TNF 14982564 1214345 Endotoxin caused transient production of and IL-6 and *activation* of [NF-kappaB] in the intestine at peak times of 1 , 4 and 1 h , respectively . Positive_regulation RELA TNF 14984720 1214716 We examined the effects of SUN C8079 on the transcriptional responses of NF-kappaB , on *activation* of [NF-kappaB] in electrophoretic mobility shift assay , and on the gene expressions of and iNOS . Positive_regulation RELA TNF 14985701 1214928 It has been reported that curcumin inhibits *induced* [NFkappaB] activity that is essential for Bcl-2 protein induction . Positive_regulation RELA TNF 14985941 1228006 We examined whether or not IVIG inhibits induced *activation* of transcription factor [NF-kappaB] , a factor that is essential for the expression of proinflammatory cytokines , in human monocytic U-937 cells . Positive_regulation RELA TNF 14985941 1228008 The inhibitory effect of IVIG on [NF-kappaB] activation *induced* by was evaluated by Western blotting and flow cytometry . Positive_regulation RELA TNF 14985941 1228010 These findings suggest that IVIG inhibits induced [NF-kappaB] *activation* in monocytes/macrophages , and blocks FcgammaRIII on the membranes of monocytes/macrophages . Positive_regulation RELA TNF 14991270 1215459 This study addresses the question whether the garlic metabolites diallyldisulfide ( DADS ) and allylmercaptane ( AM ) influence the induced *activation* of [NF-kappaB] and the NF-kappaB regulated endothelial gene product E-selectin in human umbilical endothelial cells ( HUVECs ) . Positive_regulation RELA TNF 14995068 1182921 Differential involvement of ceramide in mediated *activation* of [NF-kappaB] in primary human keratinocytes and HaCaT keratinocytes . Positive_regulation RELA TNF 14995068 1182923 It is well known that TNFalpha activates the transcription factor NF-kappaB , but there have been controversial reports on the role of ceramide in mediated [NF-kappaB] *activation* . Positive_regulation RELA TNF 14995068 1182925 Here we show by different lines of experimental evidence that is a strong *inducer* of [NF-kappaB] in both cell types , whereas C2-ceramide failed to activate NF-kappaB in HaCaT keratinocytes in contrast to primary keratinocytes . Positive_regulation RELA TNF 15001576 1236985 The receptor associated factor ( TRAF ) protein family members are critically *involved* in activation of [NF-kappaB] , JNK , and p38 activation triggered by tumor necrosis factor (TNF) receptor family members and toll/interleukin-1 receptor ( TIR ) -containing receptors . Positive_regulation RELA TNF 15033450 1223451 EGCG did not influence *stimulated* [NF-kappaB] activation . Positive_regulation RELA TNF 15033733 1184089 We here demonstrate that sulindac inhibited mediated [NF-kappaB] *activation* and greatly enhanced TNF-alpha induced apoptosis in human gastric MKN45 and cervical HeLa carcinoma cell lines . Positive_regulation RELA TNF 15044447 1251316 hCG treatment prevented the *dependent* [NF-kappaB] and AP-1 activation , which paralleled a decrease in the phosphorylation and degradation of IkappaBalpha . Positive_regulation RELA TNF 15053878 1229835 Furthermore , UV-C and daunorubicin inhibit *induced* [NF-kappa B] transactivation , indicating that this is a dominant effect . Positive_regulation RELA TNF 15056867 1230154 It was found that overexpression of Tom1 suppresses activation of transcription factors , [NF-kappaB] and AP-1 , *induced* by either IL-1beta or and that the VHS domain of Tom1 is indispensable for its suppressive activity . Positive_regulation RELA TNF 15067740 1232061 [ Effect of Triptolide on induced *activation* of [NF-kappaB] and expression of COX-2 and iNOS in human rheumatoid arthritis synovial fibroblasts ] . Positive_regulation RELA TNF 15068390 1184284 Kinetic experiments in HeLa cells show that stimulation first *induced* [NF-kappa B] DNA binding within 30 minutes , followed by I kappa B-alpha gene transcription 30 minutes later . Positive_regulation RELA TNF 15068390 1184290 Removal of after stimulation *resulted* in a faster decrease in both [NF-kappa B] DNA binding activity and I kappa B-alpha mRNA levels . Positive_regulation RELA TNF 15068815 1232319 Butyrate inhibited *induced* activation of [nuclear factor-kappaB (NF-kappaB)] in HUVEC . Positive_regulation RELA TNF 15106733 1240551 plus IFN-gamma can *induce* extracellular signal regulated kinase ( ERK ) , IKK , IkappaB degradation and [NF-kappaB] activation . Positive_regulation RELA TNF 15115707 1279364 Both kinases associate with TNFR-1 in *response* to and are required for TNFR-1 serine phosphorylation , [NF-kappaB] activation , and inhibition of apoptosis . Positive_regulation RELA TNF 15117677 1279430 PKC-delta and -epsilon regulate [NF-kappaB] activation *induced* by cholecystokinin and in pancreatic acinar cells . Positive_regulation RELA TNF 15117677 1279436 [NF-kappaB] *activation* by CCK-8 and required translocation but not tyrosine phosphorylation of PKC-delta . Positive_regulation RELA TNF 15122760 1242310 CPT treatment completely abrogated the *induced* [NF-kappa B] activation , and mRNA expression of the antiapoptotic factors TNF-receptor associated factor 2 , FLICE-inhibitory protein , and X-linked inhibitor of apoptosis protein was also inhibited by CPT. The caspase inhibitors benzyloxycarbonyl-Val-Ala-Asp- ( OMe ) -fluoromethylketone ( zVAD-fmk ) and benzyloxycarbonyl-Asp ( OMe ) -Glu ( OMe ) -Val-Asp ( OMe ) -chloromethylketone ( zDEVD-fmk ) , as well as depletion of intracellular ATP by fructose prevented CPT/TNF induced apoptosis . Positive_regulation RELA TNF 15131058 1245551 Apigenin also inhibited *induced* activation of [NF-kappaB] via the IkappaBalpha pathway , thereby sensitizing the cells to TNF-alpha induced apoptosis . Positive_regulation RELA TNF 15140884 1252106 Downregulation of PIAS3 by RNA interference reverses its effect on mediated [NF-kappaB] *activation* . Positive_regulation RELA TNF 15144120 1247556 In vitro expression of and *activation* of [NF-kappaB] in synovial fibroblasts after infection with Yersinia enterocolitica or Salmonella enteritidis was analysed by electrophoretic mobility shift assay , Western blot assay and real-time PCR . Positive_regulation RELA TNF 15157676 1250595 SMase also augmented mediated [nuclear factor kappaB (NF-kappaB)] *activation* . Positive_regulation RELA TNF 15161907 1273344 Our results show that mangiferin blocks *induced* [NF-kappaB] activation and NF-kappaB dependent genes like ICAM1 and COX2 . Positive_regulation RELA TNF 15162831 1253062 These results indicate that endogenous production of in macrophages/monocytes is *required* for [NFkappaB] activation by irradiation . Positive_regulation RELA TNF 15167811 1280259 , but not insulin , *led* to rapid activation of [NFkappaB] ( nuclear factor kappaB ) . Positive_regulation RELA TNF 15167972 1253500 We examined whether or not IVIG inhibits induced *activation* of transcription factor [NF-kappaB] , a factor that is essential for the expression of proinflammatory cytokines , in human coronary artery endothelial cells ( CAEC ) . Positive_regulation RELA TNF 15167972 1253502 The inhibitory effect of IVIG on [NF-kappaB] activation *induced* by was evaluated by Western blot analysis and ELISA . Positive_regulation RELA TNF 15167972 1253507 Western blot analysis and ELISA demonstrated that IVIG inhibits [NF-kappaB] activation *induced* by in CAEC . Positive_regulation RELA TNF 15167972 1253512 The data suggest that IVIG inhibits [NF-kappaB] activation *induced* by in CAEC , thereby possibly modulating IL-6 production and E-selectin expression . Positive_regulation RELA TNF 15173580 1254229 Conversely , suppression of beta-arrestin 1 , but not beta-arrestin 2 , expression by using RNA interference led to a 3-fold increase in *stimulated* [NF-kappaB] activity as measured by NF-kappaB mobility-shift analysis . Positive_regulation RELA TNF 15175554 1254919 Electrophoresis mobility shift assay ( EMSA ) and Western blot analysis showed that both the [nuclear factor-kappaB (NF-kappaB)] and the specificity protein-1 (SP-1) were *activated* by . Positive_regulation RELA TNF 15175554 1254923 However , NAC only partially inhibited the induced *activation* of [NF-kappaB] , but abolished the activation of SP-1 . Positive_regulation RELA TNF 15192014 1295267 These findings provide direct evidence that phosphorylation of p65 at S536 is required for induced [NF-kappaB] *activation* in the JB6 transformation model . Positive_regulation RELA TNF 15208311 1281192 TNAP specifically inhibits [NF-kappaB] activation *induced* by , TNF receptor 1 , TRADD , RIP , TRAF2 , and NIK but does not affect IKK1- and IKK2 mediated NF-kappaB activation . Positive_regulation RELA TNF 15208311 1281196 Knockdown of TNAP by lentiviral mediated small interference RNA potentiates induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 15208654 1281284 vIRF3 repressed NF-kappaB dependent transcription in a dose dependent manner and inhibited the activation of [NF-kappaB] *induced* by . Positive_regulation RELA TNF 15209356 1261761 ( 10 ng/ml ) *increased* [NF-kappaB] DNA binding activity in nuclear extracts of osteoblasts . Positive_regulation RELA TNF 15209356 1261765 The addition of NAC ( N-acetyl cysteine ) , free radical scavenger , completely prevented induced *activation* of [NF-kappaB] . Positive_regulation RELA TNF 15212763 1262305 We report that although *induced* [NF-kappaB] transcriptional activity is abolished in IKKgamma ( -/- ) cells , adenoviral gene delivery of NIK ( Ad5NIK ) still enhanced transcriptional activity and IL-6 mRNA accumulation . Positive_regulation RELA TNF 15219804 1263967 Effects of antioxidants and nitric oxide on induced adhesion molecule expression and [NF-kappaB] *activation* in human dermal microvascular endothelial cells . Positive_regulation RELA TNF 15219804 1263969 To evaluate the role of antioxidants and nitric oxide in modulating inflammatory processes in the skin , we examined the effects of pyrrolidine dithiocarbamate ( PDTC , 0.1 mM ) and spermine NONOate ( Sper-NO , 1 mM ) on adhesion molecule expression and [nuclear factor kappa B (NF-kappaB)] activation *induced* by ( 10 ng/ml ) in cultured human dermal microvascular endothelial cells ( HDMEC ) . Positive_regulation RELA TNF 15219804 1263971 The mRNA expression of E-selectin , ICAM-1 and VCAM-1 , and activation of [NF-kappaB] *induced* by for 2 h were significantly decreased by the above two pretreatments . Positive_regulation RELA TNF 15226458 1268834 However , if zinc was added back , all PPAR agonists significantly downregulated the mediated *induction* of inflammatory transcription factors [NF-kappaB] and AP-1 and significantly reduced the expression of their target genes , VCAM-1 and IL-6 . Positive_regulation RELA TNF 15234187 1269471 In TNFalpha stimulated HUVEC , simvastatin decreased VCAM-1 and ICAM-1 mRNA levels , inhibited induced *activation* of [nuclear factor kappaB (NF-kappaB)] and enhanced expression of peroxisome proliferator activated receptor alpha ( PPARalpha ) . Positive_regulation RELA TNF 15240695 1270294 *activates* Syk protein tyrosine kinase leading to TNF induced MAPK activation , [NF-kappaB] activation , and apoptosis . Positive_regulation RELA TNF 15240695 1270328 Jurkat cells that did not express Syk ( JCaM1 , JCaM1/lck ) showed lack of TNF induced Syk , JNK , p38 MAPK , and p44/p42 MAPK activation , as well as induced IkappaBalpha phosphorylation , IkappaBalpha degradation , and [NF-kappaB] *activation* . Positive_regulation RELA TNF 15240695 1270332 induced [NF-kappaB] *activation* was enhanced by overexpression of Syk by Syk-cDNA and suppressed when Syk expression was down-regulated by expression of Syk-small interfering RNA ( siRNA-Syk ) . Positive_regulation RELA TNF 15240695 1270358 Overall , our results demonstrate that Syk activation plays an essential role in *induced* activation of JNK , p38 MAPK , p44/p42 MAPK , [NF-kappaB] , and apoptosis . Positive_regulation RELA TNF 15252041 1289923 *induced* [NF-kappaB] reporter gene transcription was also suppressed in GSK-3beta gene deleted cells . Positive_regulation RELA TNF 15256485 1322064 Such sensitization is closely associated with the inhibitory effect of PN on mediated [NF-kappaB] *activation* . Positive_regulation RELA TNF 15256485 1322066 Our study revealed a new mechanism that PN inhibits mediated [NF-kappaB] *activation* via disrupting the recruitment of the IkappaB kinases (IKK) complex to TNF receptor , which then blocked the subsequent signaling events including IKK kinase activation , IkappaBalpha degradation , p65 nuclear translocation , DNA binding and transactivation . Positive_regulation RELA TNF 15265936 1275714 Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates *induced* [NF-kappa B] activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma : correlation with suppression of COX-2 synthesis . Positive_regulation RELA TNF 15265936 1275717 Akt activation , which is required for induced [NF-kappa B] *activation* , was also suppressed by this drug . Positive_regulation RELA TNF 15276019 1276773 PEDF or an antioxidant , N-acetylcysteine , significantly inhibited the *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 15276019 1276781 The results demonstrated that PEDF inhibited *induced* [NF-kappaB] activation and subsequent IL-6 overexpression in HUVEC by suppressing NADPH oxidase mediated ROS generation . Positive_regulation RELA TNF 15284221 1277879 Inhibition of AR abrogated TNF-alpha induced activation and membrane translocation of PKC , and antisense ablation of AR prevented both *induced* PKC and [NF-kappaB] activation . Positive_regulation RELA TNF 15291876 1278736 CAPE prevented paclitaxel and mediated [NF-kappaB] *activation* . Positive_regulation RELA TNF 15293554 1278957 This study also addresses PDTC and Sper-NO effects on activation of [nuclear factor kappa B (NF-kappaB)] *induced* by ( 10 ng/ml ) . Positive_regulation RELA TNF 15293554 1278963 The mRNA accumulation of IL-8 , MCP-1 , RANTES , and eotaxin , and activation of [NF-kappaB] were *induced* by for 2 h ; Positive_regulation RELA TNF 15310755 1303554 At the same time , the binding of AIP1 to TRAF2 inhibits *induced* [IKK-NF-kappaB] signaling . Positive_regulation RELA TNF 15313421 1285506 In this context , we have previously demonstrated that deacetylase inhibitors ( HDACi ) synergize with *induced* [NF-kappaB] to activate the HIV-1 promoter . Positive_regulation RELA TNF 15319427 1322735 Deletion of the ULD rendered IKKbeta catalytically inactive and unable to induce NF-kappaB activity , and overexpression of only the ULD dose-dependently inhibited *induced* [NF-kappaB] activity . Positive_regulation RELA TNF 15322087 1323102 Guggulsterone suppressed DNA binding of [NF-kappaB] *induced* by , phorbol ester , okadaic acid , cigarette smoke condensate , hydrogen peroxide , and interleukin-1 . Positive_regulation RELA TNF 15336952 1291319 Vitamin A may inhibit Sephadex induced lung granulomatous formation , and eosinophilic and neutrophilic infiltration due to its suppression of and eotaxin production , and [NF-kappaB] *activation* . Positive_regulation RELA TNF 15337758 1323382 However , TRADD and RIP , which are essential for the induced [NF-kappaB] *activation* , were not involved in the FasL induced NF-kappaB activation . Positive_regulation RELA TNF 15337758 1323391 Moreover , CLARP/FLIP inhibited the FasL- but not the induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 15355560 1293117 Mechanistic studies showed that ABD056 caused osteoclast apoptosis and inhibited *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 15367354 1297112 [ The inhibition of *induced* [NF-kappaB] nuclear translocation in ECV304 cells by mAbs against human TNF ] . Positive_regulation RELA TNF 15367354 1297114 To identify the inhibition of *induced* [NF-kappaB] nuclear translocation by three anti-human TNF mAbs , D2 , E6 and F6 . Positive_regulation RELA TNF 15367354 1297116 All of the three anti-TNF mAbs could inhibit *induced* [NF-kappaB] nuclear translocation in a dose dependent manner . Positive_regulation RELA TNF 15367354 1297118 mAbs D2 , E6 and F6 can specifically inhibit *induced* [NF-kappaB] nuclear translocation , which lays the foundation for preparation of therapeutic chimeric anti-human TNF antibody for treatment of infectious and autoimmune diseases . Positive_regulation RELA TNF 15383566 1298932 In the present report we investigated the effect of MDA-7 on [NF-kappaB] activation and on induced NF-kappaB *activation* and apoptosis in human embryonic kidney 293 cells . Positive_regulation RELA TNF 15383566 1298936 However , induced [NF-kappaB] *activation* was significantly enhanced in mda-7 transfected cells , as indicated by DNA binding , p65 translocation , and NF-kappaB dependent reporter gene expression . Positive_regulation RELA TNF 15383566 1298940 Cytoplasmic MDA-7 with deleted signal sequence was as effective as full-length MDA-7 in potentiating *induced* [NF-kappaB] reporter activity . Positive_regulation RELA TNF 15383566 1298942 Secretion of MDA-7 was not required for the potentiation of induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 15383566 1298946 Overall , our results indicate that stable or transient MDA-7 expression alone does not substantially activate NF-kappaB , but potentiates *induced* [NF-kappaB] activation and NF-kappaB regulated gene expression . Positive_regulation RELA TNF 15388451 1300347 We observed that PI pretreatment blocked the TLR2- and TLR4- as well as the *mediated* [NF-kappaB] activation , in a dose dependent manner . Positive_regulation RELA TNF 15389516 1354251 P(3)-25 inhibited induced [NF-kappaB] *activation* as detected by gel shift assay and dependent reporter gene expression . Positive_regulation RELA TNF 15451058 1300826 Ex vivo , zinc protected MNC from *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 15464842 1305168 In spite of this BZLF1 associated increase in the nuclear form of NF-kappaB , BZLF1 did not induce binding of NF-kappaB to NF-kappaB responsive promoters ( as determined by chromatin immunoprecipitation assay ) in vivo , although treatment *induced* [NF-kappaB] binding as expected . Positive_regulation RELA TNF 15465831 1342240 BRE , brain and reproductive organ expressed protein , was found previously to bind the intracellular juxtamembrane domain of a ubiquitous death receptor , tumor necrosis factor receptor 1 ( TNF-R1 ) , and to down-regulate induced *activation* of [NF-kappaB] . Positive_regulation RELA TNF 15474016 1318808 We show here that A20 , a NF-kappaB-inducible zinc finger protein that has been demonstrated to be an inhibitor of induced [NF-kappaB] *activation* and a physiological suppressor of inflammatory response , potently inhibited TLR3- and Sendai virus mediated activation of ISRE and NF-kappaB and IFN-beta promoter in reporter gene assays . Positive_regulation RELA TNF 15485901 1320806 alpha *induction* of [NF-kappaB] requires the novel coactivator SIMPL . Positive_regulation RELA TNF 15489888 1342738 In the present study , we investigated the effect of almost a dozen different commonly used NSAIDs on induced [NF-kappaB] *activation* and NF-kappaB regulated gene products , and on cell proliferation . Positive_regulation RELA TNF 15489888 1342740 All compounds inhibited induced [NF-kappaB] *activation* , but with highly variable efficacy . Positive_regulation RELA TNF 15492857 1321723 The *induced* activation of c-Jun N-terminal kinase (JNK) , p38 , and [NF-kappaB] was not affected by Delta-1 stimulation . Positive_regulation RELA TNF 15501764 1327090 In this regard , the ability of LT-IIbB to activate [NF-kappaB] and *induce* and IL-8 was antagonized by the LT-IIb holotoxin . Positive_regulation RELA TNF 15504940 1327580 HGF also blunted induced nuclear translocation and *activation* of [NF-kappaB] , a pivotal transcription factor that regulates chemokine expression . Positive_regulation RELA TNF 15518815 1328735 The subunits of NF-kappaB activated by TNF and WNV differed , WNV activated a p65/p50 NF-kappaB complex while *activated* [NF-kappaB] was composed of p65 , p50 , and c-Rel . Positive_regulation RELA TNF 15518815 1328737 Furthermore , induced *activation* of [NF-kappaB] occurred earlier than WNV induced NF-kappaB activation . Positive_regulation RELA TNF 15522867 1359774 We have recently identified an inducible [nuclear factor-kappaB (NF-kappaB)] regulator , IkappaB-zeta , which is *induced* by microbial ligands for Toll-like receptors such as lipopolysaccharide and the proinflammatory cytokine interleukin (IL)-1beta but not by . Positive_regulation RELA TNF 15526279 1360003 Endothelial cell myosin light chain kinase (MLCK) regulates *induced* [NFkappaB] activity . Positive_regulation RELA TNF 15526279 1360021 Both *induced* increase in NFkappaB dependent transactivation measured by NFkappaB luciferase reporter assay ( approximately fivefold ) and nuclear translocation of [NFkappaB] were significantly inhibited by MLCK-selective inhibitors , KT5926 ( 60 % inhibition of luciferase activity ) and ML7 ( 50 % decrease ) . Positive_regulation RELA TNF 15526279 1360027 Furthermore , our data revealed that inhibition of MLCK attenuated the *induced* IkappaB phosphorylation , translocation of p65 , NFkappaB-DNA binding , and [NFkappaB] transcriptional activity . Positive_regulation RELA TNF 15526279 1360030 Molecular approaches to either reduce EC MLCK expression ( AdV EC MLCK antisense construct ) or to reduce kinase activity ( kinase-dead EC MLCK ATPdel mutant ) produced similar attenuation of the *induced* [NFkappaB] response . Positive_regulation RELA TNF 15526279 1360034 Together , these novel observations indicate that TNFalpha induced cytoskeletal rearrangement driven by MLCK activity is necessary for dependent [NFkappaB] *activation* and amplification of pro-survival signals . Positive_regulation RELA TNF 15530848 1332712 In contrast , antioxidants did not prevent *induced* Akt and [NF-kappaB] activation . Positive_regulation RELA TNF 15542663 1337444 Previous findings from this laboratory demonstrated that the E3 proteins 10.4K and 14.5K , which form a complex in the plasma membrane , inhibit *induced* activation of [NF-kappaB] and the synthesis of chemokines . Positive_regulation RELA TNF 15550448 1367859 [NF-kappaB] , an inhibitor of the type I collagen promoters , is *increased* by both acetaldehyde and . Positive_regulation RELA TNF 15550448 1367861 This study determined the effects of acetaldehyde in comparison to the effects of on inhibitory kappa B-alpha ( IkappaB-alpha ) protein and [NF-kappaB] *activation* in hepatic stellate cells . Positive_regulation RELA TNF 15550448 1367865 Both acetaldehyde and enhanced nuclear NF-kappaB ( p65 ) , but acetaldehyde alone also *increased* [NF-kappaB] ( p50 ) . Positive_regulation RELA TNF 15550448 1367867 and acetaldehyde independently *activate* [NF-kappaB] by rapid enhancement of IkappaB-alpha kinase activity and degradation of IkB-alpha protein . Positive_regulation RELA TNF 15554267 1338744 Vitamin C blocks *induced* [NF-kappaB] activation and ICAM-1 expression in human neuroblastoma cells . Positive_regulation RELA TNF 15554267 1338748 Moreover , a gel shift analysis indicated that vitamin C dose-dependently inhibited the [NF-kappaB] activation and IkappaBalpha degradation *induced* by . Positive_regulation RELA TNF 15557193 1340493 In parallel studies we observed that inhibition of the RhoA/ROCK pathway by the same pharmacological and genetic approaches failed to inhibit *induced* [NF-kappaB] activation and ICAM-1 expression . Positive_regulation RELA TNF 15563986 1341374 Furthermore , *activated* [nuclear factor-kappaB (NF-kappaB)] , known as a downstream effector of PKCzeta to 256.6 % , which was enhanced with overexpression of wild-type PKCzeta . Positive_regulation RELA TNF 15572679 1344362 Receptor interacting protein ( RIP ) plays a critical role in induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 15572679 1344365 We found that induced [NF-kappaB] *activation* was fully restored by MEKK3-DD in these cells . Positive_regulation RELA TNF 15572679 1344368 In contrast , expression of a fusion protein composed of NEMO , a component of the IkappaB kinase complex , and the death domain of RIP ( NEMO-DD ) can not restore induced [NF-kappaB] *activation* in RIP-deficient cells . Positive_regulation RELA TNF 15572679 1344370 These results indicate that the role of RIP is to specifically recruit MEKK3 to the TNF-alpha receptor complex , whereas the forced recruitment of NEMO to the TNF-alpha receptor complex is insufficient for induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 15572679 1344372 Although MEKK2 has a high degree of homology with MEKK3 , MEKK2-DD , unlike MEKK3-DD , also fails to restore induced [NF-kappaB] *activation* in RIP-deficient cells , indicating that RIP dependent recruitment of MEKK3 plays a specific role in TNF-alpha signaling . Positive_regulation RELA TNF 15581626 1345184 As oxidative stress is one of the most prominent activators of JNK , we investigated the relationship between induced [NF-kappaB] *activation* and the control of oxidative stress . Positive_regulation RELA TNF 15589482 1356235 In addition , luteolin inhibited induced phosphorylation of p38 MAPK and extracellular regulated kinases (ERK) , IkappaB degradation , and [NF-kappaB] *activation* . Positive_regulation RELA TNF 15592525 1361665 Here , we addressed the role of endogenous caspase-8 in induced *activation* of [NF-kappaB] . Positive_regulation RELA TNF 15592525 1361670 Direct targeting of caspase-8 with siRNA and antisense ( AS ) approaches abolished induced *activation* of [NF-kappaB] in NIH3T3 , HeLa , and HEK293 cells as determined with luciferase reporter gene and cell fractionation assays . Positive_regulation RELA TNF 15592525 1361678 Taken together , these results suggest that endogenous caspase-8 mediates induced *activation* of [NF-kappaB] via FLASH . Positive_regulation RELA TNF 15593196 1346315 These studies were performed to determine if *induced* [NF-kappaB] controls the expression of FLIP long ( FLIP ( L ) ) and FLIP short ( FLIP ( S ) ) in RA synovial fibroblasts and to determine the role of FLIP in the control of TNFalpha induced apoptosis . Positive_regulation RELA TNF 15596807 1356612 Like E1A , E6 has been reported to sensitize cells to lysis by TNF-alpha by inhibiting the *induced* activation of [NF-kappaB] . Positive_regulation RELA TNF 15596807 1356614 We found that E1A , but not E6 , blocked the induced *activation* of [NF-kappaB] , an activity that correlated with E1A-p300 binding . Positive_regulation RELA TNF 15604270 1346849 In tubular LLC-PK(1) cells , *activation* of [nuclear factor kappaB (NFkappaB)] by resulted in HIF-1alpha protein synthesis as determined by [ ( 35 ) S ] methionine pulse experiments . Positive_regulation RELA TNF 15616312 1357503 Within 6 h of exposure , and N-9 *triggered* [NF-kappaB] and AP-1/cFos activation and upregulated interleukins and an array of chemokines by vaginal and polarized cervical epithelial cells . Positive_regulation RELA TNF 15642133 1363099 EGF alone did not activate NF-kappaB or alter [NF-kappaB] *activation* by . Positive_regulation RELA TNF 15647756 1363643 In this study , we have compared *induced* activation of [NF-kappaB] , phosphorylation of IkappaBalpha , and the expression of IKKbeta between lymphocytes from young and aged humans . Positive_regulation RELA TNF 15648785 1350030 The results showed that LPS elevated the production of , IL-6 , and IL-10 and enhanced [NF-kappaB] *activation* in rat intestine . Positive_regulation RELA TNF 15650392 1364023 Tumor necrosis factor-alpha (TNFalpha) and hydrogen peroxide ( H2O2 ) both activated p38 , but only *activated* [nuclear factor-kappaB (NF-kappaB)] . Positive_regulation RELA TNF 15650393 1364032 Studies of nuclear factor-kappaB (NFkappaB) activation , an essential event in IL-8 production , showed decreased induced [NFkappaB] *activation* by acrolein , illustrated by inhibition of nuclear translocation of NFkappaB and reduced IkappaBalpha degradation . Positive_regulation RELA TNF 15650394 1364038 Curcumin inhibited both H2O2- and mediated *activation* of [NF-kappaB] and AP-1 , and IL-8 release . Positive_regulation RELA TNF 15657077 1364651 Overexpression of TRIP6 potentiates NF-kappaB activation by TNF , IL-1 , TLR2 or Nod1 , whereas a dominant negative mutant or RNA-interference construct of TRIP6 inhibits [NF-kappaB] *activation* by , IL-1 , TLR2 or Nod1 . Positive_regulation RELA TNF 15662752 1350350 It became known , that oxidized LDL can inhibit LPS induced binding of the NF-kappaB to DNA and the subsequent expression of and interleukin-1beta in macrophages as well as oxidized LDL modulates *activation* of [NF-kappaB] in mononuclear phagocytes by altering the degradation of I-kappaBs . Positive_regulation RELA TNF 15664394 1365243 However , only *activated* [NF kappa B] . Positive_regulation RELA TNF 15665513 1365451 However , the existence of this inhibitory JNK pathways suggests a mechanism whereby -- in the absence of [NF-kappaB] *activation* -- production during inflammation in vivo could actually inhibit MUC2 production , giving rise to the defective mucosal protection which characterizes inflammatory bowel disease . Positive_regulation RELA TNF 15665514 1365461 Because the endotoxin stress response in ventricular myocytes involves the upregulation of , and the *activation* of [NF-kappaB] , the effects of rosiglitazone on lipopolysaccharide induced NF-kappaB dependent transcription were also investigated . Positive_regulation RELA TNF 15670894 1366052 Pretreating Colon 26 cells with IL-10 significantly attenuated the induced [NF-kappa B] *activation* . Positive_regulation RELA TNF 15671209 1366101 Phloretin did not affect *stimulated* activation of [nuclear factor kappaB (NF-kappaB)] but inhibited activation of interferon regulatory factor 1 , a transcription factor involved in the regulation of endothelial cell adhesion molecule expression . Positive_regulation RELA TNF 15677444 1395384 We identified importin alpha3 and importin alpha4 as the main importin alpha isoforms mediating *stimulated* [NF-kappaB] p50/p65 heterodimer translocation into the nucleus . Positive_regulation RELA TNF 15683721 1370654 All three cytokines alone induced the activation of AP-1 while IL-1beta and but not IFN-gamma *induced* the activation of [NF-kappaB] . Positive_regulation RELA TNF 15684769 1350957 These results suggest that may be an *inducer* of [NF-kappaB] activation and MnSOD expression after SCI and that MnSOD expression induced by TNF-alpha is likely mediated through activation of NF-kappaB . Positive_regulation RELA TNF 15687330 1402547 3 ) activation *induced* increased nuclear translocation of [NF-kappaB] , which was inhibited by pretreatment with either Thal or N-tosyl-L-phenylalanine chloromethyl ketone , an NF-kappaB inhibitor . Positive_regulation RELA TNF 15687330 1402550 The current study showed for the first time that Thal treatment attenuated the expression of IL-8 by reducing induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 15687488 1382423 Reduction of the protein level of endogenous CPAP by RNA interference resulted in decreased *activation* of [NF-kappaB] by . Positive_regulation RELA TNF 15695400 1371849 Moreover , CLIC4-antisense induction increased TNFalpha mediated apoptosis in both the SaOS and U2OS derivative cell lines without altering *induced* [NFkappaB] activity . Positive_regulation RELA TNF 15696169 1372178 Using TCPTP-deficient fibroblasts , we show here that TCPTP regulates *induced* MAPK but not [NF-kappaB] signaling . Positive_regulation RELA TNF 15698590 1372321 However , the effects of statin on the expression of and *activation* of [NF-kappaB] in endothelial cells stimulated by CRP are less studied . Positive_regulation RELA TNF 15698590 1372333 CRP stimulation result in induction of and *activation* of [NF-kappaB] , and this effect could be significantly inhibited by fluvastatin , suggesting that CRP may play a direct role in atherogenesis by activating endothelial cells , and statins inhibit this response , which may provide an insight into the mechanisms of anti-inflammatory or anti-atherosclerotic actions of statins . Positive_regulation RELA TNF 15699580 1376341 In addition , SH inhibited the increase of *induced* [NF-kappaB] protein levels , transcription factor of TNF-alpha from 293T cells . Positive_regulation RELA TNF 15701708 1388735 AGIX-4207 did not inhibit *induced* nuclear translocation of nuclear factor of the kappa-enhancer in B cells ( [NF-kappaB] ) , suggesting that the mechanism of action is independent of this redox-sensitive transcription factor . Positive_regulation RELA TNF 15709200 1373292 In this cell line , DHMEQ completely inhibited the induced *activation* of [NF-kappaB] . Positive_regulation RELA TNF 15722197 1374650 The *activation* of [NF-kappaB] and phosphatidylinositol-3 (PI3) kinase by and TRAIL overrides the pro-apoptotic effects of these ligands in carcinoma cells and hinders their therapeutic application . Positive_regulation RELA TNF 15723296 1376701 In Myd88 ( -/- ) mice after PH , induction of expression of immediate early genes involved in hepatocyte replication and phosphorylation of STAT3 in the liver , and production of by and *activation* of [NF-kappaB] in the Kupffer cells were grossly subnormal and were associated with impaired liver regeneration . Positive_regulation RELA TNF 15727562 1416782 *caused* maximal nuclear translocation of [NF-kappaB] within 15 min , compared with 1 h in cells pretreated with MitoVit E . Positive_regulation RELA TNF 15728492 1377305 Taken together our results suggest a model in which IFN-gamma induced *activates* [NF-kappaB] , which is required for full COX-2 expression . Positive_regulation RELA TNF 15731292 1439219 The inflammatory cell infiltrate , blood vessel formation , and angiogenic factors , [NF-kappaB] *activation* , expression of and interleukin 1beta (IL1beta) , and the presence of cyclo-oxygenase (COX)-1 and COX-2 were quantified . Positive_regulation RELA TNF 15743837 1379132 Here we report that eIF4GI , which is a scaffold protein interacting with many translation factors , interacts with TRAF2 , a signaling molecule that plays a key role in *activation* of [NF-kappaB] through . Positive_regulation RELA TNF 15755871 1397101 Finally , we show that beta2-integrins , which are not necessary for induced [NF-kappaB] *activation* at 37 degrees C , transduce costimulatory signals allowing NF-kappaB activation after heat exposure . Positive_regulation RELA TNF 1577874 187552 Furthermore , could still *activate* [NFkB] in this variant , suggesting that this pathway is not involved in TNF mediated cytotoxicity . Positive_regulation RELA TNF 15791843 1352664 To investigate the effect of N-tosyl-L-phenylalanylchloromethyl ketone ( TPCK ) on induced [NF-kappaB] *activation* and apoptosis in U937 cell line , changes and subcellular localization of NF-kappaB/p65 and IkappaB-alpha were observed by fluorescencemicroscopy and expression and degradation of IkappaB-alpha by flow cytometry . Positive_regulation RELA TNF 15802795 1390726 Treatments of xanthoangelol D but not xanthoangelol , xanthoangelol E and F markedly suppressed both of basal and induced [NF-kappaB] *activation* in PAECs . Positive_regulation RELA TNF 15811852 1410610 In this study , we investigated recruitment of coactivators ( SRC-1 , SRC-2 , and SRC-3 ) and corepressors ( HDAC1 , HDAC2 , HDAC3 , SMRT , and NCoR ) to the IkappaB alpha gene promoter after [NF-kappaB] *activation* by . Positive_regulation RELA TNF 15818692 1393482 *induced* activation of [NF-kappaB] and AP-1 was decreased in the primary dermal fibroblasts with the C43S TNFRSF1A mutation . Positive_regulation RELA TNF 15823455 1393896 We therefore evaluated the effects of pyrrolidine dithiocarbamate ( PDTC ; 0.1 mM ) and spermine NONOate ( Sper-NO ; 1 mM ) on adhesion molecule expression and [nuclear factor kappa B (NF-kappaB)] activation *induced* by ( 10 ng/ml ) in cultured human pulmonary microvascular endothelial cells ( PMVEC ) . Positive_regulation RELA TNF 15823455 1393898 The mRNA expression of E-selectin , ICAM-1 and VCAM-1 , and activation of [NF-kappaB] *induced* by for 2 h were decreased significantly by the above two pretreatments . Positive_regulation RELA TNF 15824857 1394064 Only a few TRACP ( + ) multinucleate cells were formed , and *mediated* activation of JNK , [NF-kappaB] , and NFATc1 was defective . Positive_regulation RELA TNF 15828019 1425364 To search for new approaches to limit cartilage damage , we investigated the requirement of polyamines for [NF-kappaB] *activation* by in human C-28/I2 chondrocytes , using alpha-difluoromethylornithine ( DFMO ) , a specific polyamine biosynthesis inhibitor . Positive_regulation RELA TNF 15837794 1432558 Expression of this protein inhibited *induced* activation of [NFkappaB] , JNK , and p38 MAPK and sensitized the cells to TNF induced apoptosis . Positive_regulation RELA TNF 15855164 1425581 Finally , Dok-4 enhanced mediated [NF-kappaB] *activation* , whereas this was inhibited by transfection with Dok-4 small interfering RNA . Positive_regulation RELA TNF 15855164 1425586 These data suggest a role for mitochondrial Dok-4 as an anchoring molecule for the tyrosine kinase c-Src , and in turn as a regulator of mediated ROS production and [NF-kappaB] *activation* . Positive_regulation RELA TNF 15864742 1401421 ECs infected with Ad-RacN17 attenuated the *induced* [NFkappaB] binding activity . Positive_regulation RELA TNF 15866594 1402057 The present study demonstrates for the first time that P and progestational compounds attenuate the expression of IL-8 by reducing induced [NF-kappaB] *activation* in endometriotic stromal cells , suggesting a possible molecular mechanism of hormone therapy for controlling the growth of endometriosis . Positive_regulation RELA TNF 15867352 1402119 Further , we showed that suppression of both constitutive and induced [NF-kappaB] *activation* by BRMS1 may be due to inhibition of IkappaBalpha phosphorylation and degradation . Positive_regulation RELA TNF 15870903 1405571 In addition , GA inhibited *induced* phosphorylation of p38 MAPK and extracellular regulated kinases (ERK) , I kappa B alpha degradation , and [NF-kappa B] activation . Positive_regulation RELA TNF 15876188 1439773 In HMEC-1 and HUVEC ( human umbilical-vein endothelial cells ) , also *induced* [RelA] homodimers that bound to the sequence 65-2kappaB , which specifically binds to RelA homodimers but not to NF-kappaB1/RelA heterodimers in vitro . Positive_regulation RELA TNF 15876188 1439775 These results suggest that in addition to NF-kappaB1/RelA heterodimers , also *induces* [RelA] homodimers that are functionally active . Positive_regulation RELA TNF 15878280 1411330 Compound 3 proved active in selectively inhibiting the *induction* of [NF-kappaB] by in T cells . Positive_regulation RELA TNF 15879145 1406062 In this study we demonstrate that a highly purified low endotoxin pancreatic elastase preparation ( El-UP ) failed both to activate [NF-kappaB] and to *induce* release in RAW 264.7 cells and bone marrow derived macrophages . Positive_regulation RELA TNF 15879156 1406166 Gene transfer of TIMP-3 inhibits the *induced* activation of [NF-kappaB] in rheumatoid arthritis synovial fibroblasts and reduces the up-regulation of soluble Fas/CD95 by TNF-alpha , but has no effects on the cell surface expression of Fas . Positive_regulation RELA TNF 15893971 1407697 We generated transgenic mice carrying a C-terminal deleted form of PW1 ( DeltaPW1 ) which blocks p53 mediated cell death and mediated [NFkappaB] *activation* fused to the myogenin promoter . Positive_regulation RELA TNF 15897777 1408648 In addition , ESM also significantly inhibited *induced* translocation of [nuclear factor kappaB (NF-kappaB)] from cytoplasm to nuclei in endothelial cells . Positive_regulation RELA TNF 15913942 1465009 In comparison , LPS induced a much greater activation of [NF-kappaB] and TNFalpha promoters , and secretion into the supernatant was strongly *induced* . Positive_regulation RELA TNF 15918511 1413270 In addition , using the SEAP ( Secreted alkaline phosphatase ) assay system , we investigated the in vitro anti-inflammatory activity of the 70 % ethanol extract of the roots of S. bockii , which showed moderate activity in inhibiting induced [NF-kappaB] *activation* with an IC50 value of 166.6 microg/mL . Positive_regulation RELA TNF 15922994 1427217 We also observed that tropisetron is a potent inhibitor of PMA plus ionomycin induced NF-(kappa)B activation but in contrast mediated [NF-(kappa)B] *activation* was not affected by this antagonist . Positive_regulation RELA TNF 15934029 1414644 An aqueous stem bark extract of Mangifera indica ( Vimang ) inhibits T cell proliferation and *induced* activation of nuclear transcription factor [NF-kappaB] . Positive_regulation RELA TNF 15934029 1414649 Moreover , the extract prevented *induced* IkappaBalpha degradation and the binding of [NF-kappaB] to the DNA . Positive_regulation RELA TNF 15943618 1415872 mediated *activation* of [NF-kappaB] has been proposed to be one pathway leading to transcriptional activation of CMV ie gene expression . Positive_regulation RELA TNF 15949909 1465027 Addition of purified NSmase to ANA-1 cell cultures stimulated [NFkappaB] binding , increased transcriptional activity in cells transfected with NFkappaB responsive promoters , and *induced* expression . Positive_regulation RELA TNF 15950952 1427657 The selective impact of HDAC inhibitors on TNF-alpha induced NF-(kappa)B activation appears to relate to the fact that the induced *activation* of [NF-(kappa)B] is mediated by the proteasome , whereas NF-kappaB activation by IL-1beta is largely proteasome independent . Positive_regulation RELA TNF 15951441 1440624 NIBP overexpression potentiates induced [NF-kappaB] *activation* through increased phosphorylation of the IKK complex and its downstream I(kappa)B(alpha) and p65 substrates . Positive_regulation RELA TNF 15951441 1440630 Finally , knockdown of NIBP expression by small interfering RNA reduces *induced* [NF-kappaB] activation , prevents nerve growth factor induced neuronal differentiation , and decreases Bcl-xL gene expression in PC12 cells . Positive_regulation RELA TNF 15953363 1421746 It inhibits *induced* PI3-kinase , Akt and [NF-kappaB] activation in these cells . Positive_regulation RELA TNF 15975820 1434702 IL-17 also inhibited the *mediated* expression of adhesion molecule VCAM-1 , and the [NF-kappaB] binding to the VCAM-1 promoter-specific site , along with the inhibitor of NF-kappaB , IkappaB-beta . Positive_regulation RELA TNF 15979856 1452536 In order to study the relationship between the constitutively active NF-kappaB and IkappaB-alpha , a dominant negative mutant IkappaB-alpha ( IkappaB-alphaDN ) , lacking the N-terminal 36 amino acids required for the *activation* of [NF-kappaB] by , was expressed in the Daudi cells . Positive_regulation RELA TNF 15980038 1465250 Fas associated death-domain protein inhibits *mediated* [NF-kappaB] activation in cardiomyocytes . Positive_regulation RELA TNF 15980038 1465276 FADD expression also inhibited mediated [NF-kappaB] *activation* in human endothelial cells but not in rat pulmonary artery smooth muscle cells . Positive_regulation RELA TNF 15987860 1429157 LGG reduced the *induced* [NFkappaB] translocation to the nucleus and lessened the decrease in IkappaB in the cytoplasm ( P < 0.05 ) . Positive_regulation RELA TNF 16006484 1459284 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the transcription factor ( [NF-kappaB] ) in lung tissue before and for 2 h after endotoxin . Positive_regulation RELA TNF 16007145 1465534 We found that zerumbone suppressed [NF-kappaB] activation *induced* by , okadaic acid , cigarette smoke condensate , phorbol myristate acetate , and H2O2 and that the suppression was not cell type specific . Positive_regulation RELA TNF 16011481 1459396 *induces* [NF-kappaB] ( nuclear factor kappaB ) and AP-1 ( activator protein 1 ) nuclear binding activities . Positive_regulation RELA TNF 16012749 1431685 Furthermore , exogenously added ATIII induced a G-protein coupled signal transduction process in CD4+ T-cells and inhibited *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 16018991 1465696 Moreover , ghrelin inhibited induced *activation* of [nuclear factor-kappaB (NF-kappaB)] in HUVECs . Positive_regulation RELA TNF 16020544 1453195 superfamily receptors typically *induce* both [NF-kappaB] and JNK activation by recruiting the TRAF2 signal transduction protein to their cytoplasmic domain . Positive_regulation RELA TNF 16025521 1435672 This dual function of NF-kappaB emphasizes the need for therapeutics that can inhibit both induced [NF-kappaB] *activation* and cell death . Positive_regulation RELA TNF 16027228 1465986 We found that UVB , IL-1 , and *induced* [NF-kappaB] activation and then produced MMP-1 and bFGF in HaCaT keratinocytes and skin fibroblasts . Positive_regulation RELA TNF 16033420 1436118 3-OMS also inhibited [nuclear factor kappaB (NF-kappaB)] binding activity *induced* by or by the combination of TNF-alpha and Abeta . Positive_regulation RELA TNF 16040075 1453589 ( TNF-alpha ) *triggers* biphasic activation of the [NF-kappaB] transcriptional regulator . Positive_regulation RELA TNF 16040075 1453591 This ability was attributed to blockage of the persistent phase of induced [NF-kappaB] *activation* for the following reasons : ( 1 ) the initial phase of NF-kappaB transcriptional activation was not affected by the MC159 protein ; Positive_regulation RELA TNF 16040075 1453593 In contrast , MC159-TRAF2 associations are more relevant for inhibitory function since mutant MC159 proteins unable to bind TRAF2 also can not inhibit mediated [NF-kappaB] *activation* . Positive_regulation RELA TNF 16041832 1498670 Although lipofection induced can *activate* [nuclear factor kappaB (NF-kappaB)] , which , in turn , increases the transgene expression from plasmid DNA in which any NF-kappaB responsive element is incorporated , no attempts have been made to use such biological responses as NF-kappaB activation against a vector to enhance vector mediated gene transfer . Positive_regulation RELA TNF 16042757 1459696 Taken together , our data suggest that both the secretion of VEGF from glioma cells and activation of [NFkappaB] in endothelial cells *induced* by are necessary for endothelial cell survival as they increase the expression of antiapoptotic genes in endothelial cells under conditions of serum starvation . Positive_regulation RELA TNF 16043718 1441899 *induced* [NF-kappaB] and p38 kinase activities and clinical symptoms of collagen induced arthritis in mice were all diminished . Positive_regulation RELA TNF 16051251 1525204 Therefore , we investigated the effect of statins on *induced* [NF-kappaB] signaling in human endothelial cells ( EC ) . Positive_regulation RELA TNF 16051251 1525206 Statin-treatment prevented *induced* [NF-kappaB] binding activity , nuclear translocation of the NF-kappaB p65 subunit , as well as NF-kappaB controlled tissue factor ( TF ) gene transcription in cultured EC . Positive_regulation RELA TNF 16051251 1525217 These studies demonstrate that induced [NF-kappaB] *activation* is abrogated by statin treatment in HUVEC independently of the classical IKK-pathway but via inhibition of PI3-kinase/Akt signaling . Positive_regulation RELA TNF 16055086 1442053 The nuclear translocation of p50/p50 complex due to M. leprae treatment correlated with repression of [NF-kappaB-driven] transcription *induced* by . Positive_regulation RELA TNF 16080915 1442776 Comparative gene array analysis of *induced* MAPK and [NF-kappaB] signaling pathways between retinal ganglion cells and glial cells . Positive_regulation RELA TNF 16081638 1466260 is a potent *activator* of [NF-kappaB] , and levels of this cytokine are increased within the myometrium at term . Positive_regulation RELA TNF 16084531 1481904 The interference with the TNFalpha pathway is reflected by reduced NFkappaB activation in anti-oxidants treated cells but the compounds are not able to contrast *mediated* activation of [NFkappaB] . Positive_regulation RELA TNF 16105982 1482164 Exogenous *enhanced* [NF-kappaB] nuclear translocation in MDS BMMCs above baseline levels . Positive_regulation RELA TNF 16107322 1496320 The herb treatment suppressed LPS stimulated TNFalpha release in vivo and by cultured KC. Direct addition of the aqueous herb extract suppressed [NF-kappaB] *activation* by KC and promoter activity in RAW cells under LPS stimulation . Positive_regulation RELA TNF 16116965 1449132 1 h , 2 h , 4 h and 6 h after LPS injection , the *activation* of [NF-kappaB] in blood mononuclear cells and the content of and IL-6 in plasma was detected by enzyme linked immunoadsordent assay ( ELISA ) . Positive_regulation RELA TNF 16117790 1449209 RXM partially suppressed p38 phosphorylation and [NFkappaB-driven] luciferase activity *induced* by and IFNgamma . Positive_regulation RELA TNF 16122789 1546736 Treatment of cells with BAY 11-7082 at 50 microM significantly inhibited basal , LPS- and *induced* [NF-kappaB] and COX-2 expression , and IL-6 and PGF2alpha release . Positive_regulation RELA TNF 16123045 1467037 In vivo , *induced* [NF-kappaB] as determined by whole mouse body bioluminescence . Positive_regulation RELA TNF 16123700 1449419 The result of EMSA showed that capsaicin inhibited induced [nuclear factor-kappa B (NF-kappaB)] *activation* in PF-10 cell cultures . Positive_regulation RELA TNF 16129813 1450023 The *induced* increase in [nuclear factor (NF)-kappaB] DNA binding activity was significantly suppressed by TDZD-8 . Positive_regulation RELA TNF 16129813 1450031 GSK-3 regulates *induced* IkappaB-alpha degradation and [NF-kappaB] activation independent of IkappaB-kinase-beta and subsequent induction of TF and VCAM-1 expression in human endothelial cells . Positive_regulation RELA TNF 16132362 1450155 In human colon epithelial cells , the effect of quercetin on induced [nuclear factor kappa B (NFkappaB)] *activation* was examined . Positive_regulation RELA TNF 16132362 1450157 Furthermore , quercetin dose-dependently inhibited an inflammatory signal *dependent* [NFkappaB] activation . Positive_regulation RELA TNF 16132362 1450159 Our data suggest that rutin acted as a quercetin deliverer to the large intestine and its anti-inflammatory action in TNBS induced colitis rats may be through quercetin mediated inhibition of induced [NFkappaB] *activation* . Positive_regulation RELA TNF 16135789 1450386 Reconstitution of RelA-deficient murine embryonic fibroblasts with RelA S276A or RelA S536A decreased *induced* acetylation of lysine 310 and expression of the endogenous [NF-kappaB-responsive] E-selectin gene . Positive_regulation RELA TNF 16140265 1454787 We also found that SM-7368 strongly inhibits *induced* [NF-kappaB] activity but not AP-1 activity . Positive_regulation RELA TNF 16141211 1467205 Differences in *induced* STAT3/DNA binding activity and not [NFkappaB] and AP-1 transcriptional activation correlated with impaired collagen accumulation/TIMP-1 induction in TNFR2 ( -/- ) cells . Positive_regulation RELA TNF 16143316 1454925 Parallel with inhibitory effect on cell growth , HCA dose dependency inhibited induced *activation* of [NF-kappaB] accompanied with inhibition of the translocation of p50 . Positive_regulation RELA TNF 16144315 1451529 To investigate the regulatory effects of various anti-inflammatory drugs on both endogenous and induced [NF-kappaB] *activation* as well as the relative biological activity . Positive_regulation RELA TNF 16144315 1451531 L ( -1 ) ) can decrease both endogenous and *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 16144315 1451533 However , its influence on induced [NF-kappaB] *activation* is needed for further study . Positive_regulation RELA TNF 16162672 1461509 Transfection experiments indicated that OspG can prevent phospho-IkappaBalpha degradation and [NF-kappaB] activation *induced* by stimulation . Positive_regulation RELA TNF 16164629 1456328 A20 , but not A1 , inhibited *induced* [NF-kappaB] activation by preventing IkappaBalpha degradation , hence subsequent up-regulation of the proinflammatory molecules ICAM-1 and MCP-1 . Positive_regulation RELA TNF 16181613 1468114 Honokiol inhibits *stimulated* [NF-kappaB] activation and NF-kappaB regulated gene expression through suppression of IKK activation . Positive_regulation RELA TNF 16181613 1468116 We observed that the induced [NF-kappaB] *activation* was blocked by honokiol in four different cancer cell lines as evidenced by EMSA . Positive_regulation RELA TNF 16186825 1468300 TAK1-deficient cells failed to activate transcription factor [NF-kappaB] and mitogen activated protein kinases in *response* to interleukin 1beta , and Toll-like receptor ligands . Positive_regulation RELA TNF 16191192 1468317 In *response* to , latent cytoplasmic [NF-kappaB] is activated , enters the nucleus , and induces expression of inflammatory and anti-apoptotic gene expression programs . Positive_regulation RELA TNF 16192349 1468329 Here , we demonstrate that *promotes* the association of [RelA] with RelB in the nucleus and that TNF-alpha induced RelA/RelB heterodimers do not bind to kappaB sites . Positive_regulation RELA TNF 16192349 1468338 In the absence of RelA phosphorylation on serine-276 , stimulation *leads* to a strong increase in the expression of endogenous [NF-kappaB-responsive] genes , such as Bcl-xL , whose transcriptional up-regulation is mainly controlled by RelB . Positive_regulation RELA TNF 16203735 1483202 Reducing Monarch-1 expression with small interference RNA in myeloid/monocytic cells caused a dramatic increase in [NFkappaB] activation and cytokine expression in *response* to TLR2/TLR4 agonists , , or M. tuberculosis infection , suggesting that Monarch-1 is a negative regulator of inflammation . Positive_regulation RELA TNF 16206033 1464147 Furthermore , the two phthalides exhibited significant suppressive effects on mediated [nuclear factor-kappaB (NF-kappaB)] *activation* in reporter gene assays . Positive_regulation RELA TNF 16210331 1468665 ( ii ) isometric contraction and ( iii ) *induced* nuclear translocation of the pro-inflammatory transcription factor [nuclear factor-kappaB (NF-kappaB)] . Positive_regulation RELA TNF 16210331 1468667 Second , the two drugs block the *induced* nuclear translocation of the pro-inflammatory transcription factor [NF-kappaB] . Positive_regulation RELA TNF 16211219 1464523 [NF-kappaB] was *activated* by ; Positive_regulation RELA TNF 16223606 1469370 The stimulation of neutrophil-like differentiated HL60 cells with *induced* activation of [NFkappaB] and c-Src kinase , and the activation was attenuated by treatment with the anti-oxidants . Positive_regulation RELA TNF 16233921 1508278 The results from the systems showed that all the three mAbs could neutralize TNF mediated cytotoxicity in L929 cells , induced [NF-kappaB] *activation* in ECV304 cells , and TNF upregulated ICAM-1 surface expression on ECV304 cells in dose dependent manners . Positive_regulation RELA TNF 16242240 1501685 Neurotrophic factors increase *induced* nuclear translocation of [NF-kappaB] in rat PC12 cells . Positive_regulation RELA TNF 16242240 1501693 These results suggested that there is a close correlation between the signaling pathways via TNF receptors and neurotrophin receptors for the NF-kappaB activation , and that NGF and BDNF enhance *induced* nuclear translocation of [NF-kappaB] . Positive_regulation RELA TNF 16246929 1471537 [NF-kappaB] *activation* in human dental pulp stem cells by and LPS . Positive_regulation RELA TNF 16246929 1471539 Because the dental pulp is frequently infected by oral bacteria due to dental decay , in this study , we examined whether lipopolysaccharide (LPS) and *activated* the immunologic transcription factor [nuclear factor kappa B (NF-kappaB)] in DPSCs . Positive_regulation RELA TNF 16253226 1483788 PGG treatment attenuated *induced* [nuclear factor-kappaB (NF-kappaB)] p65 translocation in human umbilical vein endothelial cells . Positive_regulation RELA TNF 16260783 1490026 Receptor interacting protein ( RIP ) plays a critical role in *induced* IkappaB kinase (IKK) activation and subsequent activation of transcription factor [NF-kappaB] . Positive_regulation RELA TNF 16260783 1490028 However , the molecular mechanism by which RIP mediates induced [NF-kappaB] *activation* is not completely defined . Positive_regulation RELA TNF 16260783 1490030 Moreover , a forced recruitment of TAK1 to TNF-R1 in the absence of RIP is sufficient to mediate induced [NF-kappaB] *activation* , indicating that the major function of RIP is to recruit its downstream kinases to the TNF-R1 complex . Positive_regulation RELA TNF 16269157 1525812 AR treatment attenuated *induced* [NF-kappaB] p65 translocation in HUVECs in a dose dependent manner . Positive_regulation RELA TNF 16271513 1518403 *induced* maximal [NF-kappaB] translocation in these T cells , indicating that they remain receptive to alternative signaling pathways , and pulsing with IL-12 prior to TCR triggering reversed their apparent anergy . Positive_regulation RELA TNF 16271621 1479243 Moreover , we found that depletion of GSH would also attenuate the TNF-alpha induced VCAM-1 expression with a down-regulation of the induced [NF-kappaB] *activation* and without significant effect on AP-1 . Positive_regulation RELA TNF 16271738 1502446 Furthermore , CKS significantly inhibited the *induced* production of intracellular reactive oxygen species ( ROS ) and activation of [NF-kappaB] by preventing IkappaB degradation and inhibiting IkappaB kinase activity . Positive_regulation RELA TNF 16275389 1480105 IL-17 suppressed *induced* CCL27 secretion and mRNA expression and [NF-kappaB] activity in keratinocytes . Positive_regulation RELA TNF 16276095 1502479 Only the full-length bovine FLIP protein could inhibit NF-kappaB activation induced by LPS , whereas the death effector domain region alone was able to inhibit induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 16288471 1509674 *stimulated* translocation of [NF-kappaB] into the nucleus and degradation of IkappaB-alpha was blocked by helenalin , but not by U0126 , SB202190 , or SP600125 . Positive_regulation RELA TNF 16288994 1484466 These results suggest that the inhibitory effect of equol on TNF-alpha expression is mediated , at least in part , by blocking [NF-kappaB] activation and the inhibition of expression by equol might be *involved* in its osteoprotective effect . Positive_regulation RELA TNF 16289876 1502643 A gel shift assay further showed that *induced* [Nuclear Factor-kappaB (NF-kappaB)] activity was significantly reduced by cryptotanshinone . Positive_regulation RELA TNF 16294327 1532386 Curcumin inhibited interleukin-1beta- and induced *activation* of activator protein-1 (AP-1) and mitogen activated protein ( MAP ) kinases ( ERK , c-Jun N-terminal kinase (JNK) , and p38 MAP kinase ) , but not of [nuclear factor-kappaB (NF-kappaB)] . Positive_regulation RELA TNF 16301661 1485241 Lung [NF-kappaB] activation and neutrophil recruitment *require* IL-1 and receptor signaling during pneumococcal pneumonia . Positive_regulation RELA TNF 16303143 1546891 Further , stimulation induced the degradation of IkappaB-alpha and *resulted* in the transcriptional activation of [NF-kappaB] . Positive_regulation RELA TNF 16304386 1485555 A key role is played by the presence of constitutive [nuclear factor (NF)-kappaB] , which is *induced* by LMP1 , as well as by CD30 , CD40 , , and Notch1 interactions , and results in the upregulation of at least 45 genes including chemokines , cytokines , receptors , apoptotic regulators , intracellular signaling molecules , and transcription factors . Positive_regulation RELA TNF 16318585 1487690 Further , NF-kappaB and Stat1 proteins directly regulate transcription by interacting cooperatively on [NF-kappaB-SIE] DNA binding in *response* to plus IFN-gamma . Positive_regulation RELA TNF 16318585 1487699 In contrast , IFN-gamma inhibits *induced* transcription of an [NF-kappaB] reporter gene in a Stat1 dependent mechanism in 2fTGH fibroblasts . Positive_regulation RELA TNF 16321974 1511608 We undertook an iterative computational and experimental investigation of the dynamic properties of mediated *activation* of the transcription factor [NF-kappaB] . Positive_regulation RELA TNF 16323294 1488057 Luciferase reporter gene assays further demonstrated that sKLK inhibited both basal and *stimulated* [NFkappaB] activation . Positive_regulation RELA TNF 16331273 1533103 Diosgenin suppressed *induced* [NF-kappaB] activation as determined by DNA binding , activation of IkappaBalpha kinase , IkappaBalpha phosphorylation , IkappaBalpha degradation , p65 phosphorylation , and p65 nuclear translocation through inhibition of Akt activation . Positive_regulation RELA TNF 16331685 1512041 In this report we provide evidences that oleandrin , a cardiac glycoside potentially inhibited IL-8- , formyl peptide ( FMLP ) - , EGF- , or nerve growth factor (NGF)- , but not IL-1- or *induced* [NF-kappaB] activation in macrophages . Positive_regulation RELA TNF 16338138 1526338 Enone analogues of curcumin were compared with curcumin for their abilities to inhibit the *induced* activation of [NFkappaB] , using the Panomics ' NFkappaB Reporter Stable Cell Line . Positive_regulation RELA TNF 16338458 1503943 Induction of the inhibitor may involve *stimulated* activation of [NFkappaB] . Positive_regulation RELA TNF 16339837 1539632 In contrast , Nrf2 did not inhibit induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 16352630 1504293 We have previously reported that tumor necrosis factor receptor associated factor 1 ( TRAF1 ) , an intracellular protein , which binds to a range of molecules , including tumor necrosis factor (TNF) receptor family members , regulates *induced* [NF-kappaB] and AP-1 signaling as well as TCR triggered proliferative responses in T cells . Positive_regulation RELA TNF 16360644 1512312 Epoxyquinone A monomer ( EqM ) , a synthetic derivative of the natural product epoxyquinol A , has previously been shown to be a potent inhibitor of induced *activation* of [NF-kappaB] , but the mechanism by which EqM inhibits NF-kappaB activation was not known . Positive_regulation RELA TNF 16377638 1526968 Because several of these genes are regulated by NF-kappaB , we postulated that SAHA mediates its effects by modulating NF-kappaB and found that SAHA suppressed [NF-kappaB] activation *induced* by , IL-1beta , okadaic acid , doxorubicin , lipopolysaccharide , H ( 2 ) O ( 2 ) , phorbol myristate acetate , and cigarette smoke ; Positive_regulation RELA TNF 16378960 1505361 We report here that expression of MC160 molecules did significantly reduce mediated [NF-kappaB] *activation* in 293T cells , as measured by gene reporter and gel mobility shift assays . Positive_regulation RELA TNF 16379012 1526996 A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and mediated [NF-kappa B] *activation* . Positive_regulation RELA TNF 16384711 1520061 Neutrophils from healthy volunteers ( NAC naïve ) were pre incubated with NAC for 30 min and the effects on the release of elastase and IL-8 , the respiratory burst in response to fMLP and PMA , on induced [NFkappaB] *activation* and on the migration across an endothelial-epithelial bilayer were investigated . Positive_regulation RELA TNF 16385659 1494174 To determine the functional roles of TNFR1 and TNFR2 on TNF induction , we investigated [NF-kappaB] activation and *induction* after neutralizing TNFR1 and TNFR2 by an antibody treatment . Positive_regulation RELA TNF 16385659 1494180 We found that [NF-kappaB] activation and *induction* are blocked by TNFR1 neutralizing antibody treatments . Positive_regulation RELA TNF 16394182 1533467 Arvanil also prevents induced [nuclear factor-kappaB (NF-kappaB)] *activation* by direct inhibition of IkappaBalpha degradation , NF-kappaB binding to DNA , and NF-kappaB dependent transcription . Positive_regulation RELA TNF 16399623 1513041 Silymarin is a polyphenolic flavonoid derived from milk thistle ( Silybum marianum ) and has anti-inflammatory , cytoprotective as well as anticarcinogenic effects [ Manna , S.K. , Mukhopadlhyay , A. , Van , N.T. , Aggarwal , B. , Silymarin suppresses *induced* activation of [NF-kappaB] , c-Jun N-terminal kinase , and apoptosis . Positive_regulation RELA TNF 16408291 1540226 Furthermore , the proteasome inhibitor MG-132 caused loss of IkappaBalpha , and an increase of it is phosphorylated form , but basal NF-kappaB was unchanged , whilst *activation* of [NF-kappaB] by was completely inhibited , suggesting that MG-132 activity is independent of constitutive NF-kappaB activation . Positive_regulation RELA TNF 16420740 1514810 In contrast , the broad-spectrum tyrosine kinase inhibitor genistein and the MEK-1 inhibitor ( PD98059 ) abrogated GM-CSF priming of release and *activation* of both [NF-kappaB] and AP-1 . Positive_regulation RELA TNF 16424045 1515406 Treatment with 17AAG caused degradation of RIP and IKKbeta that , in turn , blocked induced [NF-kappaB] *activation* and antiapoptotic gene expression . Positive_regulation RELA TNF 16424045 1515408 These results suggest that the cytotoxicity seen with 17AAG and TNF treatment results from blocking induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 16428340 1554357 Using EMSA , we found that *caused* [NF-kappaB] nuclear translocation in VSMCs after 1 h of incubation . Positive_regulation RELA TNF 16428340 1554359 Finally , we demonstrate that the large immunophilin FK-506 binding protein FKBP51 is essential for induced [NF-kappaB] *activation* in VSMCs . Positive_regulation RELA TNF 16432451 1516263 Sodium salicylate inhibits *induced* [NF-kappaB] activation , cell migration , invasion and ICAM-1 expression in human melanoma cells . Positive_regulation RELA TNF 16432451 1516266 The aim of this study was to investigate the effect of the non-steroidal anti-inflammatory agent sodium salicylate on *induced* activation of the transcription factor [nuclear factor-kappaB (NF-kappaB)] and upregulation of intercellular adhesion molecule-1 ( ICAM-1 ) , and TNF-alpha stimulated cell migration and invasion through fibronectin . Positive_regulation RELA TNF 16432451 1516269 Sodium salicylate inhibited *stimulated* [NF-kappaB] activation in melanoma cells in a concentration dependent manner , and this was achieved with pre-incubation times as short as 15 min. TNF-alpha stimulated ICAM-1 expression in HBL cells was also downregulated by sodium salicylate , although in a manner inversely related to the concentration of this agent . Positive_regulation RELA TNF 16432451 1516272 In conclusion , sodium salicylate effectively inhibited *induced* upregulation of [NF-kappaB] , ICAM-1 expression , in-vitro migration and invasion in human melanoma cells , indicating that non-steroidal anti-inflammatory drugs may be a useful therapeutic approach to oppose inflammation induced melanoma invasion and metastasis in vivo . Positive_regulation RELA TNF 16436709 1516542 Furthermore , ACHP inhibited *induced* [NF-kappaB] ( p65 ) recruitment to the HIV-1 LTR , as assessed by chromatin immunoprecipitation assay . Positive_regulation RELA TNF 16439527 1516609 Furthermore , both ectopically expressed SV5 SH and MuV SH blocked *activation* of [NF-kappaB] by in a reporter gene assay , suggesting that both SH proteins can inhibit TNF-alpha signaling . Positive_regulation RELA TNF 16450077 1521977 This signalling cascade is consistently associated with a reduced translocation of *activated* [NF-kappaB] into the cell nucleus . Positive_regulation RELA TNF 16464438 1534595 In order to understand underlying regulatory mechanisms , inhibition of both NF-kappaB-driven reporter gene expression and *induced* binding of [NF-kappaB] to a consensus response element was achieved at concentrations of 320 microM ( flavokavain A ) , 175 microM ( flavokavain B ) and 870 microM ( kavain and dihydrokavain ) . Positive_regulation RELA TNF 16475830 1524171 These results suggest that suppresses apoAI promoter activity through both the MEK/ERK and JNK pathways but is not *mediated* by either p38 MAP kinase activity or [NF-kappaB] activation . Positive_regulation RELA TNF 16484540 1524759 We demonstrated that 3'-hydroxy-flavone but not the chemical core structure flavone blocked *induced* [nuclear factor (NF)-kappaB] transcriptional activity and IP-10 expression at the level of NF-kappaB/IkappaBalpha phosphorylation/degradation by inhibiting IkappaB kinase activity . Positive_regulation RELA TNF 16490171 1528595 Similarly , NAC inhibited the activation of [NF-kB] *induced* by , but had no effect on the activation of NF-kappaB induced by IL-1 . Positive_regulation RELA TNF 16490171 1528599 PDTC significantly inhibited the activation of [NF-kappa B] *induced* by and IL-1 . Positive_regulation RELA TNF 16491481 1548707 *induced* [NF-kappaB] activity was determined by gel shift and reporter gene assays in addition to monitoring IkappaBalpha phosphorylation . Positive_regulation RELA TNF 16492740 1535160 *induces* ABCA1 through [NF-kappaB] in macrophages and in phagocytes ingesting apoptotic cells . Positive_regulation RELA TNF 1649771 162933 Furthermore , induces a set of genes and at least part of this transcriptional activation is *mediated* by [NF kappa B] . Positive_regulation RELA TNF 16520020 1598023 RNA interference against Nore1B attenuates NF-kappaB activation induced by T cell receptor ( TCR ) ligation , but not [NF-kappaB] activation *induced* by or lipoteichoic acid . Positive_regulation RELA TNF 16525037 1561690 ML120B concentration-dependently inhibits *stimulated* [NF-kappaB] signaling via inhibition of IkappaBalpha phosphorylation , degradation , and NF-kappaB translocation into the nucleus . Positive_regulation RELA TNF 16525884 1574383 The inhibition of LPS- and *induced* [NF-kappaB] luciferase activity in macrophages was abolished by MK-886 , a selective PPAR-alpha antagonist . Positive_regulation RELA TNF 1653056 164602 In the present work , we investigated the molecular events leading to [NF-kappa B] *activation* by in a human T cell line ( Jurkat ) and its subclone JCT6 , which presents a deficiency in the PKA transduction pathway . Positive_regulation RELA TNF 1653056 164604 Thus , induced [NF-kappa B] *activation* was found to be mediated by none of the major signal mediating kinases such as protein kinase C ( PKC ) , protein kinase A , or Ca ( 2+ ) -regulated kinases . Positive_regulation RELA TNF 1653056 164606 Furthermore , we found that cytoplasmic acidification facilitated [NF-kappa B] *activation* by both and PKC , by a mechanism that increases NF-kappa B/I kappa B dissociation without affecting the NF-kappa B translocation step . Positive_regulation RELA TNF 16543241 1555496 Previous studies indicate that RIP plays an essential role for induced [NF-kappaB] *activation* , but the molecular mechanism by which RIP mediates TNFalpha signals to activate NF-kappaB is not fully defined . Positive_regulation RELA TNF 16543241 1555498 However , it remains to be determined whether the ubiquitination of RIP is required for *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 16543241 1555500 Together , our studies provide the first genetic evidence that the ubiquitination of RIP is required for induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 16549374 1549775 Neither apoptosis nor nuclear translocation of [NF-kappaB] , *induced* in HUVEC by was influenced by 1,25 ( OH ) ( 2 ) D ( 3 ) treatment . Positive_regulation RELA TNF 16562828 1538299 Compound 2 also inhibited induced [NF-kappaB] *activation* at 5 microM through the canonical pathway , but was inactive in the Tet-On-Luc assay , indicating specificity of action , although it interfered with Tet-On-Luc at higher concentrations . Positive_regulation RELA TNF 16567640 1542319 Detailed signaling studies showed that NF-kappaB also contributes to IL-6 production and that induced [NF-kappaB] *activation* is MKK3 dependent . Positive_regulation RELA TNF 16571778 1555993 *increased* [NF-kappaB] expression and its activation , and dexamethasone partially reversed these effects . Positive_regulation RELA TNF 16573520 1582516 Mutation of the amino acid residues Trp24 and Pro41 in the COMM domain of COMMD6 completely abolished the inhibitory effect of COMMD6 on induced [NF-kappaB] *activation* , but this was not accompanied by loss of interaction with COMMD1 , COMMD6 or the NF-kappaB subunit RelA . Positive_regulation RELA TNF 16574777 1562436 These findings support the interpretation that mitochondrial generated ROS is a principal component in TNF-alpha induced effects and that Trx2 blocks induced ROS generation and downstream [NF-kappaB] *activation* and apoptosis . Positive_regulation RELA TNF 16581045 1496468 Signal transduction studies revealed that IL-1beta and stimulation *induced* [NFkappaB] phosphorylation in A549 cells , but antagonist inhibition of NFkappaB p50-p65 phosphorylation correlated with marked reduction of IL-1beta or TNF-alpha induced CCL28 expression . Positive_regulation RELA TNF 16581780 1543837 We recently reported that NS5A protein interacts with TRAF2 and modulates *induced* [NF-kappaB] and Jun N-terminal protein kinase (JNK) . Positive_regulation RELA TNF 16581780 1543839 Since NS5A and NS5B are the essential components of the HCV replication complex , we examined whether NS5B could modulate *induced* [NF-kappaB] and JNK activation . Positive_regulation RELA TNF 16581780 1543841 In this study , we have demonstrated that *induced* [NF-kappaB] activation is inhibited by NS5B protein in HEK293 and hepatic cells . Positive_regulation RELA TNF 16581782 1543861 Further studies suggest that ER stress induces down-regulation of TRAF2 expression , which impairs induced *activation* of [NF-kappaB] and c-Jun N-terminal kinase and turns TNF-alpha from a weak to a powerful apoptosis inducer . Positive_regulation RELA TNF 16584809 1562504 *activates* the degradation of IkappaB-alpha and the nuclear import of cytoplasmic [NF-kappaB] . Positive_regulation RELA TNF 16595893 1544729 Furthermore , electrophoretic mobility shift assay showed that after the cells were incubated with pitavastatin alone or with pitavastatin and TNF-alpha for 24 h , pitavastatin significantly decreased the DNA binding activity of [NF-kappaB] *induced* by . Positive_regulation RELA TNF 16601113 1568702 Overexpression of GSK-3beta did not affect the TNF-alpha induced nuclear translocation of NFkappaB but reduced the nuclear half-life of *induced* [NFkappaB] considerably ( by as much as 9 h ) and enhanced phosphorylation ( by as much as 33 % ) . Positive_regulation RELA TNF 16603398 1550704 The receptor interacting protein kinase 1 ( RIP1 ) is essential for the *activation* of [nuclear factor kappaB (NF-kappaB)] by . Positive_regulation RELA TNF 16603398 1550707 Here , we present evidence that induces the polyubiquitination of RIP1 at Lys-377 and that this polyubiquitination is *required* for the activation of IkappaB kinase (IKK) and [NF-kappaB] . Positive_regulation RELA TNF 16604092 1562645 3. In our NF-kappaB luciferase reporter system , induced [NF-kappaB] *activation* was observed to be reduced by rosmarinic acid . Positive_regulation RELA TNF 16604092 1562650 In accordance with this result , rosmarinic acid also inhibited TNF-alpha induced phosphorylation and degradation of IkappaB-alpha , as well as nuclear translocation of [NF-kappaB] heterodimer *induced* by . Positive_regulation RELA TNF 16604421 1556591 Thalidomide ( 100-800 nM ) concentration-dependently inhibited [NFkappaB] transcriptional activity *induced* by , including IKKalpha expression and IkappaBalpha phosphorylation in HSC-T6 cells . Positive_regulation RELA TNF 16606632 1611836 We further propose a potential mechanism for this observation by demonstrating that zinc supplementation induces phosphorylation of the members of three major MAPK subfamilies regulating AP-1 and NF-kappaB activation ( ERK 1/2 , JNK and p38 ) while blocking *mediated* degradation of the inhibitory subunit I kappa B alpha and nuclear translocation of [RelA] in prostate cancer cells . Positive_regulation RELA TNF 16608838 1574929 In this study , we report that [NF-kappaB] *activation* by lipopolysaccharide and plays a pivotal role in the suppression of cyp3a4 through interactions of NF-kappaB with the PXR.retinoid X receptor ( RXR ) complex . Positive_regulation RELA TNF 16611629 1568853 *induced* a quantitatively and temporally equivalent activation of [NF-kappaB] in control and E1A transfected cells . Positive_regulation RELA TNF 16624823 1569382 We found that plumbagin inhibited [NF-kappaB] activation *induced* by , and other carcinogens and inflammatory stimuli ( e.g. phorbol 12-myristate 13-acetate , H2O2 , cigarette smoke condensate , interleukin-1beta , lipopolysaccharide , and okadaic acid ) . Positive_regulation RELA TNF 16626517 1551875 The transcription and expression of the IkappaBalphaM gene , and the inhibitory effect of IkappaBalphaM on *induced* [NF-kappaB] activation in mature DC were detected by polymerase chain reaction ( PCR ) , reverse transcription-polymerase chain reaction ( RT-PCR ) , Western blot analysis , and electrophoretic mobility shift assays , respectively . Positive_regulation RELA TNF 16626517 1551877 Furthermore , AdIkappaBalphaM significantly suppressed the induced [NF-kappaB] *activation* , augmented apoptosis , downregulated CD80 , CD83 , and CD86 surface molecules , IL-12 secretion levels and the ability to stimulate the proliferation of T cells in mature DC . Positive_regulation RELA TNF 16636195 1562944 Metformin also dose-dependently inhibited *induced* [NF-kappaB] activation and TNF-alpha induced IkappaB kinase activity . Positive_regulation RELA TNF 16636588 1583079 [NF-kappaB] was *activated* within 30 min by or interleukin-1beta (IL-1beta) . Positive_regulation RELA TNF 16636588 1583088 *Induction* of [NF-kappaB] within 30 min by and IL-1beta was mediated through intracellular calcium but not ROS . Positive_regulation RELA TNF 16636588 1583091 Silymarin inhibited *induced* calcium dependent [NF-kappaB] activation irrespective of its antioxidant effect . Positive_regulation RELA TNF 16644735 1583267 Mechanistically , our data indicated that , in *response* to , [NFkappaB/p65] phosphorylation and translocation as well as IkappaBalpha phosphorylation and degradation were unchanged , suggesting that Lnk does not modulate NFkappaB activity . Positive_regulation RELA TNF 16645635 1671989 *stimulated* both [NF-kappaB] and c-Jun NH2-terminal kinase (JNK) activities , which had opposite action on cell survival . Positive_regulation RELA TNF 16646083 1563148 Expression of A20 has been shown to protect from TNF induced apoptosis and also functions via a negative-feedback loop to block [NF-kappaB] activation *induced* by and other stimuli . Positive_regulation RELA TNF 16682409 1584046 *induced* [nuclear factor (NF)-kappaB] activation in wild-type but not in NQO1 deleted cells . Positive_regulation RELA TNF 16682409 1584048 The treatment of wild-type cells with dicoumarol , a known inhibitor of NQO1 , also abolished induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 16682409 1584067 We also found that TNF activated NQO1 , and NQO1-specific small interfering RNA abolished the induced NQO1 activity and [NF-kappaB] *activation* . Positive_regulation RELA TNF 16702954 1624670 Surprisingly , activated [NF-kappaB] *induced* mRNA expression in the presence of all DNA damage inducing agents . Positive_regulation RELA TNF 16707445 1564208 conversely , anoikis was partially reversed by [NF-kappaB] activation *induced* either by treatment or by overexpressing the NF-kappaB p65 subunit in HaCaT cells . Positive_regulation RELA TNF 16707469 1564210 Accordingly , *stimulation* of [NF-kappaB] target gene expression by was strongly decreased . Positive_regulation RELA TNF 16714332 1589915 *caused* a progressive increase in [NF-kappaB] activity after 0.5 h and ICAM-1 protein expression two- to threefold of basal after 2 h. Untreated lungs expressed a low and constant level of ICAM-1 between 0 and 3.5 h . TNF-alpha failed to induce NF-kappaB activation and ICAM-1 expression in lungs of NADPH oxidase-deficient mice lacking p47(phox) . Positive_regulation RELA TNF 16723122 1638328 Finally , we critically review the recent data highlighting the role of ROS in [NF-kappaB] *activation* by proinflammatory cytokines ( and IL-1beta ) and lipopolysaccharide (LPS) , two major components of innate immunity . Positive_regulation RELA TNF 16741515 1585357 We demonstrate that [NF-kappaB] DNA binding is *activated* by both UVB and , but discrepancies in the activation of key upstream signaling pathway components such as AKT phosphorylation and IkappaBalpha degradation exist . Positive_regulation RELA TNF 16757480 1599102 Here we show that can *lead* to the induction of [NFkappaB] signaling with a concomitant increase in spermidine/spermine N ( 1 ) -acetyltransferase ( SSAT ) expression in A549 and H157 non-small cell lung cancer cells . Positive_regulation RELA TNF 16771850 1572681 It has been reported that enterocytes produce proinflammatory mediators , including tumour necrosis factor (TNF) and PAF , and we showed that lipopolysaccharide (LPS) and *activate* [nuclear factor (NF)-kappaB] in enterocytes . Positive_regulation RELA TNF 16783201 1573692 Taken together with the dependent p38 and [NF-kappaB] *activation* in primed neutrophil , we conclude that thermal injury induced priming effect of polymorphonuclear neutrophil is TNF-alpha and p38 dependent . Positive_regulation RELA TNF 16784723 1585645 Anti-prostaglandin E2 ( PGE2 ) antiserum or antisense oligonucleotides against PGE2 receptor EP2 or EP3 abrogated inhibitory effects of ketoconazole and terbinafine hydrochloride on *induced* [NF-kappaB] activity and CCL27 , CCL2 , and CCL5 production , indicating the involvement of endogenous PGE2 in the inhibitory effects . Positive_regulation RELA TNF 16784723 1585650 Carboxyheptyl imidazole also suppressed *induced* [NF-kappaB] activity and CCL27 , CCL2 , and CCL5 production . Positive_regulation RELA TNF 16784723 1585655 These results suggest that ketoconazole and terbinafine hydrochloride may suppress *induced* [NF-kappaB] activity and CCL27 , CCL2 , and CCL5 production by increasing PGE2 release from keratinocytes . Positive_regulation RELA TNF 16784892 1599414 Thus , we hypothesized that tumor derived *induces* the activation of [NF-kappaB] and the transcription repressor YY1 , both of which negatively regulate Fas expression and sensitivity to FasL induced apoptosis . Positive_regulation RELA TNF 16785236 1599428 As examined by the DNA binding of NF-kappaB , we found that indirubin suppressed induced [NF-kappaB] *activation* in a dose- and time dependent manner . Positive_regulation RELA TNF 16785236 1599432 [NF-kappaB] reporter activity *induced* by TNFR1 , receptor associated death domain , TRAF2 , TAK1 , NF-kappaB inducing kinase , and IKKbeta was inhibited by indirubin but not that induced by p65 transfection . Positive_regulation RELA TNF 16785565 1577149 Furthermore , in tolerant cells , *induced* [NF-kappaB] p65 phosphorylation was markedly decreased , which was accompanied by the formation of C/EBPbeta-p65 complexes . Positive_regulation RELA TNF 16793775 1599603 Here , we show that the receptor interacting protein ( RIP ) , a key mediator of *induced* [NF-kappaB] and JNK activation , plays a key role in IGF-I receptor signaling . Positive_regulation RELA TNF 16794257 1631660 Quercetin also inhibited *induced* PI 3-kinase activity , Akt phosphorylation , intracellular H ( 2 ) O ( 2 ) production , [NF-kappaB] transactivation , IL-8 promoter activity , and steady-state mRNA levels , consistent with the notion that quercetin inhibits chemokine expression by attenuating NF-kappaB transactivation via a PI 3-kinase/Akt dependent pathway . Positive_regulation RELA TNF 16835238 1606493 Analysis of differentiating epithelia showed that only well differentiated enterocytes activated the 4-kb long MLCK promoter in response to TNF , and consensus promoter reporters demonstrated that *induced* [NFkappaB] activation decreased during differentiation while TNF induced AP-1 activation increased . Positive_regulation RELA TNF 16843665 1613077 Novel curcumin analogs targeting induced [NF-kappaB] *activation* and proliferation in human leukemic KBM-5 cells . Positive_regulation RELA TNF 16843665 1613079 Copper ( II ) conjugates of all synthesized ligands were prepared and structurally characterized as well as evaluated for their potential of inhibiting induced [NF-kappaB] *activation* and proliferation in human leukemic KBM-5 cells wherein compound 13 was found to be more potent than curcumin . Positive_regulation RELA TNF 16863996 1592490 These redox alterations were found to inhibit *induced* IkappaB-alpha phosphorylation and [NF-kappaB] translocation to the nucleus , thus presumably inhibiting expression of genes necessary to inhibit the cytotoxic effects of TNF . Positive_regulation RELA TNF 16865287 1592767 G. lucidum decreased *induced* ( MCF-7 ) as well as constitutive ( MDA-MB-231 ) activity of [NF-kappaB] . Positive_regulation RELA TNF 16865289 1592769 DHMEQ blocked the constitutive DNA binding activity and *mediated* nuclear translocation of [NF-kappaB] in Huh-7 cells . Positive_regulation RELA TNF 16870149 1593092 In addition , our data show that the early expression of does not *lead* to activation of [NF-kappaB] , because disruption of TNF-alpha activity by a neutralizing antibody does not affect nuclear translocation of NF-kappaB , IkappaBalpha degradation or reporter gene activation by apicidin . Positive_regulation RELA TNF 16872805 1672446 Ad.IKKbeta+/- treatment completely inhibited *stimulated* IKK kinase activity , IkappaB alpha degradation and [NFkappaB] DNA binding in addition to completely blocking TNFalpha stimulated ICAM-1 and VCAM-1 expression . Positive_regulation RELA TNF 16873882 1593503 Recently , some important discoveries have underscored the critical role of ROS in TNFalpha signaling , notably in mediated *activation* of [nuclear factor-kappaB (NF-kappaB)] and c-Jun N-terminal kinase ( c-Jun NH2-terminal kinase , JNK ) , as well as in cell death ( apoptotic and necrotic ) pathways . Positive_regulation RELA TNF 16873882 1593505 Here we attempt to review the existing knowledge on the involvement of ROS in death receptor signaling using TNFalpha-TNFR1 as the model system , specifically addressing the involvement of intracellular ROS in TNFalpha induced cell death and in *induced* activation of [NF-kappaB] and JNK and their crosstalk . Positive_regulation RELA TNF 16874302 1600742 Upon *stimulation* of the cells by , [NF-kappaB] and TFIIH are rapidly recruited to the promoter together with additional Mediator and RNAP II , but CDK8 is lost . Positive_regulation RELA TNF 16896803 1601132 High-dose IVIG inhibited induced *activation* of [nuclear factor-kappaB (NF-kappaB)] to a greater degree than dexamethasone in human monocytic U937 cells and human coronary arterial endothelial cells ( HCAEC ) , but not in human T lymphocytic Jurkat cells . Positive_regulation RELA TNF 16904979 1601516 Therefore , we investigated the role of clathrin heavy chain (CHC) in induced IKB alpha phosphorylation and [NFKB] *activation* . Positive_regulation RELA TNF 16916935 1608535 Conversely , GRX1 knockdown sensitizes cells to oxidative inactivation of IKK-beta and dampens *induced* IKK and [NF-kappaB] activation . Positive_regulation RELA TNF 16920299 1666190 CML-1 inhibits induced [NF-kappaB] *activation* and adhesion molecule expression in endothelial cells through inhibition of IkBalpha kinase . Positive_regulation RELA TNF 16924232 1692177 We found that in wild-type mouse embryonic fibroblast (MEF) , *induced* [NF-kappaB] activation as measured by DNA binding but deletion of PKR abolished this activation . Positive_regulation RELA TNF 16928387 1632924 Furthermore , Paeonol reduced *induced* [NF-kappaB] transactivation and IFNgamma induced STAT1 transactivation in CW-2 cells and also in Jurkat cells . Positive_regulation RELA TNF 16931033 1627267 however , the contribution of mediated *increases* in nuclear [NF-kappaB] is uncertain . Positive_regulation RELA TNF 16934229 1627284 Mechanisms of crosstalk between *induced* [NF-kappaB] and JNK activation in hepatocytes . Positive_regulation RELA TNF 16934424 1724326 *upregulates* VCAM-1 and [NF-kappaB] in fibroblasts from nasal polyps . Positive_regulation RELA TNF 16934424 1724330 The activation of [NF-kappaB] *induced* by was determined by electrophoretic mobility shift assays and the influence on the expression of VCAM-1 was investigated . Positive_regulation RELA TNF 16934424 1724332 [NF-kappaB] activity was *enhanced* by stimulation and remarkably suppressed by NF-kappaB proteasome inhibitor . Positive_regulation RELA TNF 16936197 1608946 *Activation* of [NF-kappaB] by 2 , TRAF6 , NF-kappaB inducing kinase , or protein kinase D , which transduce signals downstream of Toll-like receptors , TNF receptors , and free radicals , respectively , were all potent activators of the A20 promoter . Positive_regulation RELA TNF 16939707 1666200 Differential effect of Rhizoma coptidis and its main alkaloid compound berberine on *induced* [NFkappaB] translocation in human keratinocytes . Positive_regulation RELA TNF 16952378 1639505 This study was designed to determine whether N-acetylcysteine (NAC) , an antioxidant , prevents the *activation* of [nuclear factor-kappaB (NF-kappaB)] by exogenously administered in adipocytes , and whether such change affects the production of adipocytokines . Positive_regulation RELA TNF 16952378 1639511 The present study revealed that NAC inhibited the mediated *activation* of [NF-kappaB] and improved the adverse changes in the levels of IL-6 , PAI-1 and adiponectin in 3T3-L1 adipocytes . Positive_regulation RELA TNF 16955245 1611104 After a 4 h recovery period from heat shock , there was inhibition of mediated [NF-kappaB] *activation* . Positive_regulation RELA TNF 16973825 1616856 Resveratrol also inhibited *induced* , [NF-kappaB-driven] luciferase expression in rat aortas electroporated with the reporter gene construct . Positive_regulation RELA TNF 16973825 1616858 Thus resveratrol at nutritionally relevant concentrations inhibits induced [NF-kappaB] *activation* and inflammatory gene expression and attenuates monocyte adhesiveness to HCAECs . Positive_regulation RELA TNF 16981138 1617047 We characterized the *induced* binding of [NF kappaB] to this motif . Positive_regulation RELA TNF 16982330 1617121 The apoptotic potential of M8 and RV was compared using a specific double staining method and inhibition of induced *activation* of [NF-kappaB] was studied . Positive_regulation RELA TNF 16987412 1628282 Furthermore , strongly *activated* [nuclear factor-kappa B (NF-kappaB)] as measured by reporter gene assays and by an activity-specific antibody . Positive_regulation RELA TNF 16987412 1628290 mediated activation of IKK-beta *resulted* in activation of [NF-kappaB] and was followed by up-regulation of the bona-fide target gene cyclin D1 . Positive_regulation RELA TNF 17005413 1641122 Coincident with this observation , TSA induced a concentration dependent reduction of constitutive and induced [NF-kappaB] *activation* in Tca8113 cells . Positive_regulation RELA TNF 17005669 1641147 Consistent with this , we further show that an HCMV variant that has lost the ability to downregulate *induced* [NF-kappaB] signaling also fails to downregulate surface expression of TNF receptor 1 , thereby mechanistically linking the inhibition of TNF-alpha induced NF-kappaB signaling by HCMV to TNF receptor targeting . Positive_regulation RELA TNF 17008396 1674098 However , *induced* a p52/RelB [NFkappaB] DNA binding complex in p50 null MEC nuclear extracts . Positive_regulation RELA TNF 17010424 1666324 We investigated the production of and the *activation* of the nuclear transcription factor [NF-kappaB] . Positive_regulation RELA TNF 17011514 1629133 We found that PTEN inhibited [NFkappaB] activation *induced* by . Positive_regulation RELA TNF 17011643 1647599 In transient transfection reporter gene assays , SSAT2 functions as a transcriptional coactivator for NF-kappaB and cooperates with CBP and P/CAF to enhance *induced* [NF-kappaB] activity . Positive_regulation RELA TNF 17012372 1674165 MXF inhibited *stimulated* MAPKs ERK1/2 , 46-kDa JNK , and [NF-kappaB] up to 60 % , 40 % , and 40 % , respectively . Positive_regulation RELA TNF 17015749 1629901 The suppression of *induced* [NF-kappaB] activation by deguelin occurred through the inhibition of the activation of IkappaBalpha kinase , leading to sequential suppression of IkappaBalpha phosphorylation , IkappaBalpha degradation , p65 phosphorylation , p65 nuclear translocation , and NF-kappaB dependent reporter gene expression . Positive_regulation RELA TNF 17016662 1630060 Although not associated with changes in Bcl-2 , Bcl-XL , Bax , Bad or Bak expression levels , we report that the expression of the pro-apoptotic 1-95IGFBP-3 fragment is associated with the inhibition of *induced* [NF-kappaB] activity , similar to that reported for the full length IGFBP-3 protein . Positive_regulation RELA TNF 17018860 1682937 In the resting cell , RhoA suppresses Cdc42 activation , IkappaBalpha degradation , [nuclear factor-kappaB (NF-kappaB)] *activation* , and induction of and NF-kappaB dependent chemokines . Positive_regulation RELA TNF 17018860 1682942 Suppression of TNFalpha induction by RhoA is Rho kinase alpha ( ROCKalpha ) independent , but Cdc42 dependent , because TNFalpha induction by C3 transferase is attenuated by inhibition of Cdc42 , and constitutively active Cdc42 suffices to activate [NF-kappaB] and *induce* . Positive_regulation RELA TNF 17024246 1641547 In contrast , 14.7K did not affect induced [NF-kappaB] *activation* via recruitment of receptor interacting protein 1 (RIP-1) and TNF receptor associated factor 2 ( TRAF-2 ) . Positive_regulation RELA TNF 17028035 1654291 It was concluded that *activates* [NF-kappaB] and AP-1 and induces PGE ( 2 ) release which alters dose-dependently the activity of the pump by activating different EP receptors with different affinities for PGE ( 2 ) . Positive_regulation RELA TNF 17052676 1636333 However , the expression of VCAM-1 on BEAS-2B cells was only up-regulated by *induced* [NF-kappaB] activity . Positive_regulation RELA TNF 17055343 1674849 Since EMMPRIN and MMP-9 up-regulation is associated with activation of the NF-kappaB pathway , we investigated the effect of pioglitazone and resveratrol on induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 17055514 1740137 Mulberry leaf aqueous fractions inhibit induced [nuclear factor kappaB (NF-kappaB)] *activation* and lectin-like oxidized LDL receptor-1 ( LOX-1 ) expression in vascular endothelial cells . Positive_regulation RELA TNF 17055514 1740139 Furthermore , mulberry leaf aqueous fractions inhibited *induced* activation of [nuclear factor-kappaB (NF-kappaB)] and phosphorylation of inhibitory factor of NF-kappaB-alpha ( IkappaB-alpha ) in a time- and concentration dependent fashion . Positive_regulation RELA TNF 1706475 153079 No correlation exists in HL60 cells between [NF-kappa B] *activation* by ( TNF alpha ) and TNF beta and intracellular levels of cyclic AMP . Positive_regulation RELA TNF 1706475 153081 Forskolin or 1-isobutyl-3-methylxanthine drastically increased intracellular levels of cyclic AMP , but neither activated NF-kappa B nor influenced induced [NF-kappa B] *activation* . Positive_regulation RELA TNF 17075836 1649897 RhoA mediated , alpha *induced* activation of [NF-kappaB] in rheumatoid synoviocytes : inhibitory effect of simvastatin . Positive_regulation RELA TNF 17075836 1649901 This study was conducted to examine the role of RhoA in mediating the activation of NF-kappaB in tumor necrosis factor alpha (TNFalpha) stimulated rheumatoid synoviocytes , and to evaluate the modulatory effects of statins on the induced *activation* of RhoA and [NF-kappaB] and the secretion of proinflammatory cytokines by rheumatoid synoviocytes . Positive_regulation RELA TNF 17075836 1649909 This study identifies RhoA as the key regulator of induced [NF-kappaB] *activation* , which ultimately results in the secretion of proinflammatory cytokines in rheumatoid synoviocytes . Positive_regulation RELA TNF 17079781 1708971 Previously we demonstrated that in cultured mouse lung epithelial cells exposed to bolus administration of H ( 2 ) O ( 2 ) , *induced* [NF-kappaB] activity was inhibited , whereas c-Jun-N-terminal kinase (JNK) activation was enhanced via a mechanism involving TNF receptor-1 ( TNF-RI ) . Positive_regulation RELA TNF 17079781 1708986 Nox1 expression and activation inhibited *induced* inhibitor of kappaB kinase (IKK) , and [NF-kappaB] while promoting JNK activation and cell death . Positive_regulation RELA TNF 17085785 1643952 In the present study , we demonstrate that *activates* [NF-kappaB] activity in neuronal , SH-SY5Y , cells and preferentially enhances the binding of p50 and p65 to the promoter/enhancer regions of the MnSOD gene . Positive_regulation RELA TNF 17088249 1675876 Similar to the other ABINs , ABIN-3 binds to A20 and inhibits [NF-kappaB] activation *induced* by , interleukin-1 , and 12-O-tetradecanoylphorbol-13-acetate . Positive_regulation RELA TNF 17108260 1686005 Moreover , IFNgamma failed to affect *induced* IkappaKbeta phosphorylation or IkappaB degradation as well as nuclear [NF-kappaB/DNA] interaction . Positive_regulation RELA TNF 17110197 1645571 One assay analyzes the *induced* translocation of the transcription factor [NF-kappaB] from the cytoplasm into the nucleus 20 min after stimulation with TNFalpha . Positive_regulation RELA TNF 17114179 1677148 Although gamma-tocotrienol completely abolished induced [NF-kappaB] *activation* , a similar dose of gamma-tocopherol had no effect . Positive_regulation RELA TNF 17142966 1653801 stimulation *induced* the biphasic increases in expression of [NFkappaB-p65] , ST3Gal I , FUT IV , ST3Gal IV and ST6GalNAc III mRNAs and the transient increase in expression of ST6Gal I mRNA and the decrease in ST3GalNAc IV mRNA . Positive_regulation RELA TNF 17150968 1694112 In this study we show that the leave extract of WS , as well as its major constituent withaferin A ( WA ) , potently *inhibits* [NFkappaB] activation by preventing the induced activation of IkappaB kinase beta via a thioalkylation-sensitive redox mechanism , whereas other WS-derived steroidal lactones , such as withanolide A and 12-deoxywithastramonolide , are far less effective . Positive_regulation RELA TNF 17160991 1747141 Here we show that ectopic overexpression of catalytically inactive dominant negative PKR expression system suppressed [NF- kappa B] activation *mediated* by TLR3 , TLR9 , , but not by TLR4 . Positive_regulation RELA TNF 17166398 1662002 Furthermore , we found that bFGF inhibits the mediated *activation* of [NF-kappaB] by blocking phosphorylation and degradation of IkappaBalpha . Positive_regulation RELA TNF 17166398 1662005 We also found that bFGF induces hyperphosphorylation of p38 MAPK on endothelial cells , whereas inhibition of such kinase abrogates the effect of bFGF on the mediated *activation* of [NF-kappaB] . Positive_regulation RELA TNF 17178392 1679722 Simvastatin ( 50 micro M ) blocked *induced* [NF-kappaB] transcriptional activity , IkappaB phosphorylation/degradation and DNA binding activity of NF-kappaB . Positive_regulation RELA TNF 17184171 1724569 Consequently , [NF-kappaB] activity and MCP-1 and VCAM-1 *induced* by are suppressed . Positive_regulation RELA TNF 17185631 1717326 fMLP pretreatment also inhibited *activation* of proinflammatory transcription factor [NF-kappaB] by in Caco2bbe cells , reducing induction of NF-kappaB target genes by TNF-alpha both in human intestinal biopsies and Caco2bbe cells . Positive_regulation RELA TNF 17186493 1701650 In addition , KS-Fs and Kur were able to inhibit *induced* [NF-kappaB] activation in 293 cells mediated by the decreased IkappaBalpha phosphorylation . Positive_regulation RELA TNF 17189827 1680094 while *increased* the activities of both [NF-kappaB] and AP-1 . Positive_regulation RELA TNF 17200614 1358588 However , as expected , *induced* [NF-kappaB] activity was stimulated within 10-30 minutes through degradation of IkappaB-alpha . Positive_regulation RELA TNF 17201889 1680698 Tetrandrine ( 0.5-5.0 micromol/L ) concentration-dependently inhibited [NFkappaB] transcriptional activity *induced* by , including IkappaBalpha phosphorylation and mRNA expressions of ICAM-1 in HSC-T6 cells . Positive_regulation RELA TNF 17202332 1680900 Moreover , guanosine abrogated IFN-gamma induced phosphorylation on Ser ( 727 ) and translocation of STAT-1alpha to the nucleus as well as *induced* IkappaBalpha and [NF-kappaB] p65/RelA subunit phosphorylation , thus inhibiting NF-kappaB induced nuclear translocation . Positive_regulation RELA TNF 17207890 1724701 Conversely , TPA inhibited *induced* [NF-kappaB] signaling and was a weak activator of this pathway . Positive_regulation RELA TNF 17207890 1724703 Thus , TPA did not sufficiently activate NF-kappaB to increase transcription through the low affinity NF-kappaB binding sites on RANTES promoter and its inhibitory effect on *induced* [NF-kappaB] signaling resulted in a reduced transcription rate . Positive_regulation RELA TNF 17210691 1681519 The survival mechanism requires [nuclear factor-kappaB (NF-kappaB)] transcription factor activity , which is strongly *induced* by in these cells . Positive_regulation RELA TNF 17237440 1690115 Our results demonstrate that [RelA] is essential for the host defense response to pneumococcus in the lungs and that RelA in airway epithelial cells is primarily *activated* by and IL-1 . Positive_regulation RELA TNF 17240450 1696451 Pre-treatment of magnolol blocked induced [NF-kappaB] *activation* in different cell types as evidenced by EMSA . Positive_regulation RELA TNF 17241871 1690655 Consistent with the observation that TNF induced ER stress responses through grp-78 redistribution from the ER lumen to the cytoplasmic IkappaB kinase complex , grp-78 knockdown completely abolished *induced* nuclear factor-kappaB [RelA] phosphorylation in epithelial cell cultures . Positive_regulation RELA TNF 17244613 1710230 Although we have previously demonstrated that NEMO associates with both IKKs , genetic studies reveal that only its interaction with IKKbeta is required for *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 17244613 1710243 Furthermore , exogenously expressed , catalytically inactive IKKbeta blocked TNF- but not IL-1 induced IkappaBalpha degradation in wild-type MEFs , and reconstitution of IKKalpha/beta double knockout cells with IKKalpha rescued IL-1- but not *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 17256146 1725368 These experiments indicate that although both and UVB *stimulate* [NF-kappaB] DNA binding activity in normal human keratinocytes , the mechanisms of NF-kappaB activation by each stimulus is different . Positive_regulation RELA TNF 17260188 1740461 Expression of A20 has been shown to protect from TNF induced apoptosis and also functions via a negative-feedback loop to block [NF-kappaB] activation *induced* by and other stimuli . Positive_regulation RELA TNF 17266397 1725637 The effect of *induced* [NF-kappaB] signaling on Smad signaling and on in vitro osteoblast mineralization was examined using specific NF-kappaB inhibitors and activators , and effects of TNFalpha induced NF-kappaB signaling on BMP-2 induced Runx2 mRNA were examined using RT-PCR . Positive_regulation RELA TNF 17276726 1718324 We found that the overexpression of DGKalpha-WT , but not of DGKalpha-KD , further enhanced the *stimulated* transcriptional activity of an anti-apoptotic factor , [NF-kappaB] . Positive_regulation RELA TNF 17277159 1697887 We found that simvastatin inhibited *induced* [NF-kappaB] activation , and l-mevalonate reversed the suppressive effect , indicating the role of hydroxy-3-methylglutaryl-CoA reductase . Positive_regulation RELA TNF 17307735 1719150 Similarly , we showed by chromatin immunoprecipitation assays as well as by gel-shift assays with nuclear extracts that *induced* [NF-kappaB] binding to regions at positions -380 , -1420 , and -1890 , demonstrated its association with RNA polymerase II and cofactor proteins , and confirmed the functionality of the respective promoter regions in vivo . Positive_regulation RELA TNF 17314097 1719532 Interestingly , peptides spanning CCR2 and/or LZ disrupt IKKgamma-Tax and IKKgamma-PP2A interactions and potently inhibit [NF-kappaB] *activation* by Tax and . Positive_regulation RELA TNF 17314215 1740838 Artesunate also prevented *induced* nuclear [NF-kappaB] translocation , DNA binding activity and gene transcriptional activity , as well as phosphorylation and degradation of IkappaBalpha , but phosphorylation of p38 mitogen activated protein kinase , extracellular signal regulated kinase and c-Jun N-terminal kinase were unaffected . Positive_regulation RELA TNF 17316570 1705703 The results show that Akt contributes to induced [NF-kappaB] *activation* in lung cancer cells through regulating phosphorylation of the p65/RelA subunit of NF-kappaB . Positive_regulation RELA TNF 17316570 1705720 Although individually blocking IKK or Akt partially suppressed TNF induced NF-kappaB activation , concurrent suppression of these pathways completely inhibited *induced* [NF-kappaB] activation and downstream anti-apoptotic gene expression , and synergistically potentiated TNF induced cytotoxicity . Positive_regulation RELA TNF 17321745 1711807 To elucidate the molecular mechanism of inhibition of cell adhesion molecules , we investigated the status of nuclear transcription factor-kappaB ( NF-kappaB ) and were able to establish that compound 8a significantly blocked the *induced* activation of [NF-kappaB] . Positive_regulation RELA TNF 17322278 1747581 *induced* CD38 expression in human airway smooth muscle cells : role of MAP kinases and transcription factors [NF-kappaB] and AP-1 . Positive_regulation RELA TNF 17327432 1706611 These inhibitory effects may be exerted via inhibition of nuclear factor-kappaB (NF-kappaB) activation , as LR-90 suppressed both S100b-and *induced* IkappaB-alpha degradation as well as [NF-kappaB] promoter transcriptional activity . Positive_regulation RELA TNF 17327451 1706621 gAd activated NF-kappaB and enhanced *induced* [NF-kappaB] activity . Positive_regulation RELA TNF 17334236 1707605 We conclude that *induces* upregulation of PTEN expression through [NF-kappaB] activation in human leukemic cells . Positive_regulation RELA TNF 17341614 1665057 For characterization of the cell based assay , activation of the pathway by several agents , for example , tumor necrosis factor alpha (TNF-alpha) , interleukin-1beta (IL-1beta) , lipopolysaccharide (LPS) , camptothecin and phorbol ester ( PMA ) , and the influence of the culture conditions on [NF-kappaB] *activation* by were examined . Positive_regulation RELA TNF 17341614 1665060 [NF-kappaB] was *activated* by , IL-1beta , PMA , and camptothecin in a dose dependent manner , but not by LPS . Positive_regulation RELA TNF 17349210 1708024 Electrophoretic mobility shift assay ( EMSA ) revealed that *induced* [NF-kappaB] transactivation in AML14 cells in a time- and dose dependent fashion , and subsequent supershift assays indicated that the translocated NF-kappaB was the heterodimer p65 ( RelA)/p50 . Positive_regulation RELA TNF 17357478 1665120 [NF-kappaB] activity *induced* by was significantly increased in AM from patients with COPD , and pyrrolidine dithiocarbamate ( PDTC ) and N-acetyl-L-cysteine (NAC) significantly inhibited the activation of NF-kappaB induced by TNF-alpha ( P < 0.05 ) . Positive_regulation RELA TNF 17357832 1783483 The NF-kappaB activity of both cell lines was increased by the addition of TNF-alpha , while *induced* [NF-kappaB] activity was suppressed by prestimulation with GM in a dose dependent manner . Positive_regulation RELA TNF 17357832 1783486 These results indicate that GM inhibits induced [NF-kappaB] *activation* and enhances apoptosis in human pancreatic cancer cell lines . Positive_regulation RELA TNF 17363495 1712926 Both gemcitabine and *activated* [NF-kappaB] in bladder cancer cells and curcumin suppressed this activation . Positive_regulation RELA TNF 17363555 1712972 We now report that cancer associated mutant p53 can augment the induction of [nuclear factor kappaB (NFkappaB)] transcriptional activity in *response* to the cytokine . Positive_regulation RELA TNF 17373813 1720569 The present study examines the effects of selected phytochemicals and apple extracts on induced [NF-kappaB] *activation* in human breast cancer MCF-7 cells . Positive_regulation RELA TNF 17373813 1720571 Apple extracts significantly inhibited the *induced* [NF-kappaB] activation at a dose of 5 mg/mL ( p < 0.05 ) . Positive_regulation RELA TNF 17373813 1720573 Curcumin also significantly blocked the *induced* [NF-kappaB] activation at doses of 10 and 20 microM ( p < 0.05 ) . Positive_regulation RELA TNF 17384033 1715823 Electrophoretic mobility shift assay ( EMSA ) revealed that transient [NF-kappaB] activation in the COX-2 promoter was *triggered* by . Positive_regulation RELA TNF 17387141 1741627 We found that among nine different flavones tested , fisetin was potent in suppressing induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 17390058 1716114 Furthermore , EMSA showed that pitavastatin significantly reduced the DNA binding activity of [NF-kappaB] *induced* by . Positive_regulation RELA TNF 17404114 1721579 We showed by DNA binding assay that [NF-kappaB] activation *induced* by , phorbol 12-myristate 13-acetate , lipopolysaccharide , ceramide , interleukin-1 , and H ( 2 ) O ( 2 ) was suppressed by morin ; Positive_regulation RELA TNF 1740663 182092 [NF-kappa B] binding activity was *inducible* by and phorbol myristate acetate in PLB-985 . Positive_regulation RELA TNF 17434980 1772099 Anandamide dose dependently attenuated the induced ICAM-1 and VCAM-1 expression , [NF-kappaB] *activation* in HCAECs , and the adhesion of monocytes to HCAECs in a CB(1)- and CB(2) dependent manner . Positive_regulation RELA TNF 17439942 1749124 As examined by DNA binding , we found that butein suppressed induced [NF-kappaB] *activation* in a dose- and time dependent manner ; Positive_regulation RELA TNF 17449583 1730012 Quercetin inhibits *induced* [NF-kappaB] transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells . Positive_regulation RELA TNF 17449583 1730022 At the molecular level , quercetin inhibited Akt phosphorylation but did not inhibit *induced* [RelA/I-kappaB] phosphorylation and IkappaB degradation or TNF-alpha induced nuclear factor-kappaB transcriptional activity . Positive_regulation RELA TNF 17465224 1731906 Inhibition of cancer cell proliferation and suppression of *induced* activation of [NFkappaB] by edible berry juice . Positive_regulation RELA TNF 17465224 1731912 Of the 13 berries tested , juice of 6 significantly inhibited the *induced* activation of COX-2 expression and activation of the nuclear transcription factor [NFkappaB] . Positive_regulation RELA TNF 17467021 1743416 BSO attenuated the induced [nuclear factor-kappaB (NF-kappaB)] *activation* , however , with no detectable effect on AP-1 and its related mitogen activated protein kinases ( MAPKs ) . Positive_regulation RELA TNF 17475277 1744086 In STAT1-deficient mice , [nuclear factor kappaB (NF-kappaB)] *activation* by was attenuated and strongly inhibited by both NAC and L-NMMA . Positive_regulation RELA TNF 17485112 1750542 TSA1 could also inhibit TNF induced cytotoxicity on L929 cells and mediated [NF-kappaB] *activation* on HEK-293T cells . Positive_regulation RELA TNF 17485223 1750546 *Activation* of [NFkappaB] by was also abolished by preincubation of HSC with GSH , but not by deferoxamine , tempol or trolox . Positive_regulation RELA TNF 17496784 1739472 We observed that proteins expressed by Hs294T metastatic melanoma cells are highly acetylated compared with normal melanocytes , and dominant negative PCAF reduced the basal and *stimulated* transcriptional activity of [NF-kappaB] . Positive_regulation RELA TNF 17504796 1783835 The increase in eosinophil [NF-kappaB] binding activity *induced* by GM-CSF and was suppressed by NAC . Positive_regulation RELA TNF 17507688 1772761 IFN-gamma induced CD40 expression involves activation of STAT-1alpha as well as [NF-kappaB] *activation* through an autocrine response to IFN-gamma induced production . Positive_regulation RELA TNF 17516865 1745851 Zyflamend suppressed [NF-kappa B] activation *induced* by both and cigarette smoke condensate . Positive_regulation RELA TNF 1751774 173798 , interleukin 1 , and phorbol myristate acetate are independent *activators* of [NF-kappa B] which differentially activate T cells . Positive_regulation RELA TNF 17522064 1778349 The results indicate that the relative potency for suppression of induced [nuclear factor-kappaB (NF-kappaB)] *activation* was Cur > DMC > BDMC ; Positive_regulation RELA TNF 17522064 1778351 Turmerones also failed to inhibit induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 17523016 1746069 To assess the effects of hyperthermia on TNF-alpha induced up regulation of ECAM and *induced* activation of [NF-kappaB] , we measured ECAM by ELISA , and evaluated the activation of NF-kappaB by Western blotting after TNF-alpha stimulation . Positive_regulation RELA TNF 17523016 1746072 Pretreatment of hyperthermia blocks *induced* [NF-kappaB] activation , resulting in the inhibition of ECAM up regulation in HAEC . Positive_regulation RELA TNF 17533369 1822016 Although DN-IKKbeta inhibited *induced* [NF-kappaB] activity , DN-IKKbeta had no effect on EGF induced NF-kappaB activation , suggesting that EGF induced NF-kappaB activation is IKK independent . Positive_regulation RELA TNF 17537988 1784161 This novel finding supports a model , whereby dependent *activation* of [NF-kappaB] up-regulates phagocyte NADPH oxidase activity , leading to enhanced ROS production and further NF-kappaB activation , potentially contributing to sustained oxidant production in chronic inflammation . Positive_regulation RELA TNF 17541168 1746935 DHT inhibited the [NF-kappaB] activation *induced* by in a manner dependent on the androgen receptor (AR) . Positive_regulation RELA TNF 17550447 1752582 Abnormal nuclear factor (NF)-kappaB signal pathway and aspirin inhibits alpha *induced* [NF-kappaB] activation in keloid fibroblasts . Positive_regulation RELA TNF 17550447 1752584 To examine the effect of aspirin on the induced [NF-kappaB] *activation* in keloid fibroblasts . Positive_regulation RELA TNF 17550447 1752588 In this study , we demonstrate that *induced* [NF-kappaB] activation in keloid fibroblasts , which show more sensitively than the normal skin fibroblasts . Positive_regulation RELA TNF 17550447 1752593 Aspirin pretreatment can inhibit *induced* activation of [NF-kappaB] in a dose dependent manner by preventing the phosphorylation and degradation of IkappaBalpha and nuclear translocation of NF-kappaB . Positive_regulation RELA TNF 17551258 1785785 Exposure to Ang II ( 10 ( -6 ) M for 24 h ) also enhanced intracellular ROS elaboration and the levels of and interleukin (IL)-8 , upregulated chemokine receptor CXCR2 mRNA expression , increased adhesion of endothelial cells to monocytes and *induced* a significant increase in the activity of [nuclear factor (NF)-kappaB] , which was attenuated by pretreatment with the Ang II receptor blocker losartan ( 1 , 3 and 10 muM ) . Positive_regulation RELA TNF 17557931 1815636 We demonstrated using assays of nuclear localization , NF-kappaB subunit phosphorylation , DNA binding , and transcriptional activity that [NF-kappaB] is *activated* by in presheared HUVEC . Positive_regulation RELA TNF 17565651 1753561 *activated* [NF-kappaB] and up-regulated endogenous TFF1 mRNA expression as well as the transcription of the TFF1 reporter genes in a dose dependent manner . Positive_regulation RELA TNF 17567906 1763221 Functionally , transiently overexpressed Zfra sequestered [NF-kappaB] ( p65 ) , WOX1 , p53 and phospho-ERK ( extracellular signal activated kinase ) in the cytoplasm , and or UV light could not effectively *induce* nuclear translocation of these proteins . Positive_regulation RELA TNF 17570221 1753724 RelA/p65 is essential for induced [NF-kappaB] *activation* in adult hepatocytes . Positive_regulation RELA TNF 17592223 1768202 The effects of acute or chronic alcohol exposure were evaluated in human monocytes on the production of or IL-10 production , pro-inflammatory gene and [nuclear factor-kappaB (NF-kappaB)] *activation* . Positive_regulation RELA TNF 17607667 1779777 In cell lines , overexpression of p65 inhibited beta-catenin/TCF4 mediated transcription , while transfection of GSK-3beta resulted in repression of *induced* [NF-kappaB] activity . Positive_regulation RELA TNF 17617381 1769543 Methylglyoxal suppresses *induced* [NF-kappaB] activation by inhibiting NF-kappaB DNA binding . Positive_regulation RELA TNF 17617381 1769545 In this study , we show that methylglyoxal inhibits induced [NF-kappaB] *activation* and NF-kappaB dependent reporter gene expression by inhibiting the DNA binding capacity of NF-kappaB p65 . Positive_regulation RELA TNF 17624386 1775070 The synthetic glucocorticoid , dexamethasone ( DEX ) blunted *stimulated* [NF-kappaB] activation in L6 cells . Positive_regulation RELA TNF 17626094 1787404 Additionally , normal cellular TNF-alpha signaling , measured by quantitation of *induced* stimulation of transcription from an NF-kappaB-responsive reporter plasmid or [NF-kappaB] protein nuclear translocation , was blocked in DV-infected MDM and Huh7 cells . Positive_regulation RELA TNF 17639074 1829604 Presently , we show that hBVR increases PKC-zeta autophosphorylation , stimulation by , as well as cytokine *stimulation* of [NF-kappaB] DNA binding and promoter activity . Positive_regulation RELA TNF 17640567 1771200 We found that mediated [NF-kappaB] *activation* was inhibited by curcumin ; Positive_regulation RELA TNF 17641059 1771327 Indeed we found that *induced* [NF-kappaB] activation was abrogated in MKK4 gene deleted cells , as determined by DNA binding . Positive_regulation RELA TNF 17641670 1798792 Antipsoriatic effects of avarol-3'-thiosalicylate are mediated by inhibition of generation and [NF-kappaB] *activation* in mouse skin . Positive_regulation RELA TNF 17660390 1799072 *induced* [NF-kappaB] and RhoA activation and upregulation of adhesion molecules ICAM-1 and VCAM-1 , increased expression of monocyte chemoattractant protein , enhanced transendothelial migration of monocytes , and augmented monocyte-endothelial adhesion . Positive_regulation RELA TNF 17667842 1805299 Stimulation of TA cells by *increased* the activation of [NF-kappaB] , which was suppressed by the addition of AZM . Positive_regulation RELA TNF 17671727 1777154 Aqueous extract of Magnolia officinalis mediates proliferative capacity , p21WAF1 expression and *induced* [NF-kappaB] activity in human urinary bladder cancer 5637 cells ; Positive_regulation RELA TNF 17671727 1777156 Furthermore , the transactivation of *stimulated* [NF-kappaB] was inhibited by SB203580 treatment . Positive_regulation RELA TNF 17678632 1781207 TMMC inhibited induced [nuclear factor kappaB (NF-kappaB)] *activation* directly and indirectly . Positive_regulation RELA TNF 17683071 1800339 Overexpression of hBVR enhanced both the basal and mediated *activation* of [NF-kappaB] and also that of the NF-kappaB activated iNOS gene . Positive_regulation RELA TNF 17690092 1800488 Here we demonstrate in the same system that GSH depletion down-regulates induced [NF-kappaB] *transactivation* via two mechanisms , depending on the extent of the depletion . Positive_regulation RELA TNF 17690092 1800501 With moderate GSH depletion ( approximately 50 % ) , the down-regulation is IkappaB kinase (IKK) independent and likely acts on NF-kappaB transcriptional activity because *induced* IKK activation , IkappaBalpha phosphorylation and degradation , NF-kappaB nuclear translocation , NF-kappaB DNA binding in vitro , and NF-kappaB subunit [RelA] ( p65 ) recruitment to kappaB sites of target gene promoters all appear unaltered . Positive_regulation RELA TNF 17690318 1794372 Overexpression of the UCHL1 gene significantly attenuated *induced* [NF-kappaB] activity in vascular cells and increased inhibitor of kappa B-alpha ( IkappaB-alpha ) , possibly through the attenuation of IkappaB-alpha ubiquitination , leading to decreased neointima in the balloon injured artery . Positive_regulation RELA TNF 17696945 1782213 Additionally , diverse biologic roles of FLASH , including induced [NF-kappaB] *activation* , cell-cycle progression and cell division , have been identified . Positive_regulation RELA TNF 17702576 1782963 Optineurin negatively regulates *induced* [NF-kappaB] activation by competing with NEMO for ubiquitinated RIP . Positive_regulation RELA TNF 17702576 1782975 NEMO was recently found to contain a region that preferentially binds Lys ( K ) 63-linked but not K48 linked polyubiquitin ( polyUb ) chains , and the ability of NEMO to bind to K63 linked polyUb RIP ( receptor interacting protein ) is necessary for efficient induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 17702576 1782979 Optineurin competitively antagonized NEMO 's binding to polyUb RIP , and its overexpression inhibited induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 17702576 1782984 This competition occurs at physiologic protein levels because microRNA silencing of optineurin resulted in markedly enhanced *induced* [NF-kappaB] activity . Positive_regulation RELA TNF 17763449 1801867 Furthermore , APC directly suppressed the production of and the *activation* of [NF-kappaB] and MAP kinase p38 , and inhibitors of NF-kappaB or p38 reduced the production of MMP-9 , suggesting that APC inhibits MMP-9 by blocking TNF , NF-kappaB , and p38 . Positive_regulation RELA TNF 17766391 1790373 When expressed in human cells , some of the selected molecules , despite their partial degradation , inhibited mediated [NF-kappaB] *activation* while having no effect on the basal activity . Positive_regulation RELA TNF 17784835 1790511 Nuclear localization of [NF-kappaB] in *response* to was evident in differentiated , but not undifferentiated , SNUhES3 cells . Positive_regulation RELA TNF 17786184 1790844 [NFkappaB] *activation* by lipopolysaccharide and was evaluated in tumor cell lines genetically engineered to express luciferase controlled by an NFkappaB-responsive element . Positive_regulation RELA TNF 17827743 1791589 Cornuside treatment attenuated *induced* [nuclear factor-kappa B (NF-kappaB)] p65 translocation in HUVECs . Positive_regulation RELA TNF 17828497 1795614 Our results showed that could *activate* [NF-kappaB] in untransfected cells but not in transfected HSC-T6 cells . Positive_regulation RELA TNF 17855475 1823119 GLNVA also reduced cyclooxygenase (COX)-2 expression , inhibitor of nuclear factor (NF)-kappaB ( IkappaB)alpha/IkappaBbeta degradation , [NF-kappaB] *activation* , and the overproduction of , interleukin (IL)-1beta , and prostaglandin E2 in BV-2 cells . Positive_regulation RELA TNF 17878383 1797044 Activation of [NF-kappaB] , STAT6 , and STAT1 was *induced* in eosinophils by , IL-4 , and IFN-gamma , respectively . Positive_regulation RELA TNF 17878386 1797052 Moreover , and overexpression of p65 *induced* the formation of [NF-kappaB-CARD8] promoter complexes . Positive_regulation RELA TNF 17878386 1797058 Furthermore , in contrast to the full-length protein , CARD8-S did not modify the expression of [NF-kappaB] target genes ( cIAP , A1 ) , in *response* to . Positive_regulation RELA TNF 17879952 1888784 Catalase overexpression impairs *induced* [NF-kappaB] activation and sensitizes MCF-7 cells against TNF-alpha . Positive_regulation RELA TNF 17884817 1818676 By the use of HIF-1-deficient cells and by obliterating NF-kappaB activation , it was determined that the hypoxic TACE response is mediated by HIF-1 signaling , whereas the regulation by also *requires* [NF-kappaB] activation . Positive_regulation RELA TNF 17897950 1824000 However , down-regulation of USP11 dramatically enhances [NF-kappaB] activity in *response* to , indicating that IKKalpha does not require activation of NF-kappaB . Positive_regulation RELA TNF 17897957 1824026 Furthermore , overexpression of a dominant negative mutant of TAK1 blocked the induced expression of MMP-9 and *activation* of [NF-kappaB] and AP-1 . Positive_regulation RELA TNF 17904523 1803094 Gankyrin did not affect the NF-kappaB DNA binding activity or nuclear translocation of [RelA] *induced* by in these cells . Positive_regulation RELA TNF 17909069 1803590 In addition , Smad7 mediates the inhibitory activity of TGF-beta on induced [NF-kappaB] *activation* and the synergistic activity of TGF-beta on TNF induced apoptosis . Positive_regulation RELA TNF 17927961 1813263 TRAF interacting protein (TRIP) is required for the inhibitory regulation of *induced* [NF-kappaB] signaling via the TNFR/TRAF signaling complexes in vitro . Positive_regulation RELA TNF 17936907 1844361 Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli , but S. aureus fails to both activate [NF-kappaB] in mammary epithelial cells and to quickly *induce* and interleukin-8 ( CXCL8 ) expression in the udder . Positive_regulation RELA TNF 17942934 1814229 In agreement with this , we also found that TNF activated NQO2 , and NQO2-specific small interfering RNA abrogated the *induced* NQO2 activity and [NF-kappaB] activation . Positive_regulation RELA TNF 17949817 1844481 It thus activates downstream signaling events to activate transcription factor [NF-kappaB] , and *induce* the expression of IL-1 responsive genes such as and GM-CSF . Positive_regulation RELA TNF 17959522 1814952 Compared to that of the control group , activity of pulmonary [NF-kappaB] in burned rats was markedly increased within 1 PBH and kept increasing till 24 h. Expressions of pulmonary and IL-8 mRNAs *increased* gradually , reaching the peak level at 6 PBH , and PDTC could effectively inhibit pulmonary NF-kappaB activation and expression of the pulmonary cytokines induced by the burn injury . Positive_regulation RELA TNF 17977820 1845471 Phosphorylation of serine 68 in the IkappaB kinase (IKK) binding domain of NEMO interferes with the structure of the IKK complex and *induced* [NF-kappaB] activity . Positive_regulation RELA TNF 17977820 1845473 Furthermore , in complementation experiments of NEMO-deficient murine embryonic fibroblasts , a S68A-NEMO mutant enhanced , whereas a S68E mutant decreased , *induced* [NF-kappaB] activity , thus emphasizing the inhibitory role of the Ser ( 68 ) phosphorylation on the signal induced NF-kappaB activity . Positive_regulation RELA TNF 17989734 1889132 Although tumor necrosis factor (TNF) related apoptosis inducing ligand ( TRAIL ) and both *activate* [NF-kappaB] in human keratinocytes , only TRAIL potently induces apoptosis . Positive_regulation RELA TNF 17999917 1846255 On the other hand , *activated* a transcription factor [NF-kappaB] in OSCC cells , while NBD peptide , an NF-kappaB inhibitor , inhibited the ADAM-17 maturation , thus suggesting that NF-kappaB is involved in ADAM-17 maturation . Positive_regulation RELA TNF 18000166 1860126 OPG promoter functional assays and chromatin immunoprecipitation experiments revealed inhibitory effects of Nutlin-3 on the *induced* [NF-kappaB] DNA binding activity to the OPG promoter . Positive_regulation RELA TNF 18022362 1827535 IAP antagonists induce autoubiquitination of c-IAPs , [NF-kappaB] *activation* , and dependent apoptosis . Positive_regulation RELA TNF 18022363 1827541 Inhibition of NF-kappaB reduced TNFalpha production , and blocking [NF-kappaB] activation or *allowed* tumor cells to survive IAC induced apoptosis . Positive_regulation RELA TNF 18025231 1827746 In a NF-kappaB reporter system , 8K-NBD dose-dependently inhibits induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 18036510 1860858 Therefore , we evaluated the effect six different statins on induced [NF-kappaB] *activation* in human myeloid leukemia cells . Positive_regulation RELA TNF 18036510 1860860 Of the six statins evaluated , only the natural statins ( simvastatin , mevastatin , lovastatin , and pravastatin ) , not the synthetic statins ( fluvastatin and atorvastatin ) , inhibited induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 18040799 1669149 Activation of NF-kappaB by TNF-alpha and inhibition of TNF-alpha induced BDNF expression by Deltap65 ( a dominant negative mutant ) and NEMO binding domain peptide ( an inhibitor of NF-kappaB ) suggests that *induces* BDNF expression through the activation of [NF-kappaB] . Positive_regulation RELA TNF 18040839 1828578 Among the most prominent are the regulation of induced [NF-kappaB] *activation* by adapter proteins such as TRADD and TRAF , and second , the heterogeneity of microglia and their distribution pattern across brain regions . Positive_regulation RELA TNF 18049314 1833196 Oxidized dipyridamole had no effect on mediated [NF kappa B] *activation* . Positive_regulation RELA TNF 18051603 1833261 In addition , streptochlorin inhibited induced [NF-kappaB] *activation* in the newly developed cell based reporter gene assay . Positive_regulation RELA TNF 18056399 1833531 Notably , stimulation of HEK293T cells with or overexpression of the p65 subunit of NF-kappaB *resulted* in up-regulation of NLRP2 and the formation of [NF-kappaB-NLRP2] promoter complexes . Positive_regulation RELA TNF 18062932 1861581 CH3-Avn-c , a synthetically prepared methyl ester derivative of Avn-c with a high biological potency , significantly and dose dependently decreased mRNA expression and secretion of IL-6 , IL-8 , and MCP-1 by HAEC as determined by real-time RT-PCR and ELISA , and it inhibited IL-1beta- and *stimulated* [NF-kappaB] activation as determined by a NF-kappaB DNA binding assay and a NF-kappaB luciferase reporter assay . Positive_regulation RELA TNF 18064709 1937870 It is also suggested that *activates* [NF-kappaB] and increases transgene expression by pDNA having many NF-kappaB binding sites , but TNF-alpha also reduces transgene expression at later time periods , leading to short-term transgene expression . Positive_regulation RELA TNF 18067272 1853687 In a kinase gene screen using a NF-kappaB reporter , we observed that overexpression of casein kinase 1alpha (CK1alpha) enhanced TNFalpha induced NF-kappaB activation , and a CK1alpha kinase dead mutant , CK1alpha ( K46A ) , reduced [NF-kappaB] activation *induced* by . Positive_regulation RELA TNF 18068371 1874490 In this paper , we exhibit that ( i ) HIV-1gene expression was inhibited by lignin , ( ii ) fraction of small molecular mass in HBS lignin ( less than 0.5kDa ) had stronger inhibitory effects than large molecular mass ( more than 1.3kDa ) , ( iii ) lignin also inhibited activation of [NF-kappaB] *induced* by , ( iv ) among six lignin dimer-like compounds , compound 6 containing beta-5 bond has more potent inhibitory activity than compounds 1 , 2 , 3 , 4 and 5 , which contain beta-1 , beta-O-4 , 5-5 , or beta-beta structural units . Positive_regulation RELA TNF 18068998 1853785 Positive and negative signaling components involved in induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 18068998 1853787 Stimulation of cells with *triggers* activation of [NF-kappaB] through various signaling molecules , including TRAF2 , RIP , MAP3K , and the IKK complex . Positive_regulation RELA TNF 18088098 1862381 Both naphthopyrones 1 and 2 completely inhibit induced [NF-kappaB] *activation* at a concentration of 300 microM by inhibiting the enzymatic activity of the kinase IKKbeta . Positive_regulation RELA TNF 18089811 1834827 These findings show that the reduced bystander response in A549 cells is due to *activation* of [NF-kappaB] signaling by , whereas enhanced response to IR-induced bystander signaling in H460 cells was due to release of TRAIL associated with nuclear translocation of PAR-4 . Positive_regulation RELA TNF 18177902 1856274 Avarol inhibited tumor necrosis factor-alpha (TNF-alpha) generation in stimulated human monocytes ( IC ( 50 ) 1 microM ) and *induced* activation of [nuclear factor-kappaB (NF-kappaB)-DNA] binding in keratinocytes . Positive_regulation RELA TNF 18182117 1895185 , found in arthritic joints , *activates* [nuclear factor-kappaB (NF-kappaB)] , whereas retinoic acid receptors (RARs) are activated by retinoid agonists , including all-trans retinoic acid ( atRA ) . Positive_regulation RELA TNF 18182252 1856561 Alpha-lipoic acid inhibits *induced* [NF-kappa B] activation through blocking of MEKK1-MKK4-IKK signaling cascades . Positive_regulation RELA TNF 18184904 1883586 We also found a significant inhibition of *induced* [NF-kappaB] activity by visfatin ( P < 0.001 ) . Positive_regulation RELA TNF 18202703 1876403 Furthermore , *induced* [p65/RelA] phosphorylation as well as transcriptional activity of nuclear factor-kappaB (NF-kappaB) was significantly downregulated in T6 ( -/- ) 3T3 cells . Positive_regulation RELA TNF 18206350 1870564 Expression of non phosphorylated TAK1 interferes with MEKK3 phosphorylation and [NF-kappaB] reporter activity *induced* by transient MEKK3 expression or stimulation . Positive_regulation RELA TNF 18222174 1871080 Some reports have demonstrated that EPA inhibits [NF-kappaB] activation *induced* by or lipopolysaccharide (LPS) in various cells . Positive_regulation RELA TNF 18224289 1839225 TauBr inhibited degradation of IkappaBalpha and *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 18235000 1864349 *induced* the phosphorylation and downregulation of IkappaB-alpha and the translocation of the p65 subunit of [NF-kappaB] to the nucleus . Positive_regulation RELA TNF 18239058 1877020 Furthermore , LY294002 suppressed both IL-1beta- and *induced* [NF-kappaB] activation and IL-1beta- , TNF-alpha- , and IFN-gamma induced activated protein-1 (AP-1) activation . Positive_regulation RELA TNF 18250466 1865283 In this study , the effect of Lactobacillus plantarum lipoteichoic acid ( pLTA ) on LPS induced MAPK activation , [NF-kappaB] *activation* , and the expression of and IL-1R associated kinase M (IRAK-M) was examined . Positive_regulation RELA TNF 18255343 1877300 Treatment of endothelial cells with DHEAS dramatically inhibited the induced *activation* of [NF-kappaB] , an inflammatory transcription factor , and increased protein levels of the NF-kappaB inhibitor , IkappaB-alpha . Positive_regulation RELA TNF 18258304 1884805 When analyzing TNF induced NF-kappaB activity via luciferase-reporter assays or via EMSA , we were able to show that the dominant negative version of Rac could completely abrogate *induced* [NF-kappaB] activity . Positive_regulation RELA TNF 18258304 1884807 In addition , we also observed that inhibition of the ERK pathway led to a reduction in *induced* [NF-kappaB] transcriptional activity ; Positive_regulation RELA TNF 18275839 1937987 induced [NF-kappaB] *activation* and cell oxidant production are modulated by hexameric procyanidins in Caco-2 cells . Positive_regulation RELA TNF 18275839 1937989 Hexameric procyanidins inhibit *induced* [NF-kappaB] activation in Caco-2 cells . Positive_regulation RELA TNF 18275839 1937991 We investigated the capacity of a hexameric procyanidin fraction ( Hex ) to prevent *induced* [NF-kappaB] activation as related to oxidation and membrane interactions . Positive_regulation RELA TNF 18275839 1937997 In Caco-2 cells , Hex ( 2.5-20 microM ) inhibited *induced* [NF-kappaB] activation ( IkappaB phosphorylation and degradation , p50 and RelA nuclear translocation , and NF-kappaB-DNA binding ) , inducible nitric oxide synthase expression , and cell oxidant increase . Positive_regulation RELA TNF 18275839 1938000 In summary , Hex can inhibit NF-kappaB activation by interacting with the plasma membrane of intestinal cells , and through these interactions preferentially inhibits the binding of to its receptor and the subsequent [NF-kappaB] *activation* . Positive_regulation RELA TNF 18279557 1944028 EC-M17 dose dependently inhibited *induced* [NF-kappaB] signalling . Positive_regulation RELA TNF 18287053 1872498 Here , we show that the murine CMV M45 protein binds to RIP1 and inhibits *induced* activation of [NF-kappaB] , p38 MAPK , and caspase independent cell death . Positive_regulation RELA TNF 18287248 1896534 We have shown previously that flavopiridol abrogates induced [nuclear factor-kappaB (NF-kappaB)] *activation* . Positive_regulation RELA TNF 18288389 1872686 SC-514 , an inhibitor of IkappaB kinase beta (IKKbeta) , blocked the *induced* activation of [nuclear factor-kappaB (NF-kappaB)] as well as the TNF-alpha promoted metastasis of murine colon adenocarcinoma cells . Positive_regulation RELA TNF 18288389 1872689 M1 was effective in suppressing the *induced* activation of [NF-kappaB] , expression of matrix metalloprotease-9 (MMP-9) , migration and invasion . Positive_regulation RELA TNF 18289527 1878525 Ectodomain shedding of TNF receptor 1 induced by protein synthesis inhibitors regulates *mediated* activation of [NF-kappaB] and caspase-8 . Positive_regulation RELA TNF 18289527 1878528 Nevertheless , we have surprisingly found that CHX , as well as its structural analogue acetoxycycloheximide ( Ac-CHX ) , prevents *mediated* activation of [NF-kappaB] and caspase-8 in human lung carcinoma A549 cells . Positive_regulation RELA TNF 18289527 1878532 Thus , our results indicate that ectodomain shedding of TNF-R1 induced by protein synthesis inhibitors regulates *mediated* activation of [NF-kappaB] and caspase-8 . Positive_regulation RELA TNF 18292192 1911921 , acting through the TNF-R2 , *causes* an early up-regulation of [NF-kappaB] , long lasting induction of the NF-kappaB target gene inhibitor kappaB ( IkappaB ) , and persistent stimulation of other NF-kappaB associated genes including mitogen-inducible gene-6 (MIG-6) , which acts as an IkappaB signaling antagonist , and butyrate induced transcript 1 . Positive_regulation RELA TNF 18295395 1896693 Our results showed that CS inhibited induced [NF-kappaB] *activation* and subsequent vascular cell adhesion molecule 1 and inducible nitric oxide synthase expressions by blocking Akt signals in JB6 cells . Positive_regulation RELA TNF 18309109 1896986 JNK inhibitor and antioxidant also effectively blocked induced [NF-kappaB] *activation* and monolayer permeability in HCAECs . Positive_regulation RELA TNF 18309276 1873751 These extracts also inhibited mRNA expression of and IL-4 , as well as [NF-kappaB] *activation* in RBL-2H3 cells induced by the IgE-antigen complex . Positive_regulation RELA TNF 18313693 1886037 This is sufficient to alter NEMO function , since functional complementation assays using NEMO-deficient pre-B and T lymphocytes show that full-length C417F pathogenic NEMO leads to a partial to strong defect in LPS , IL-1beta and *induced* [NF-kappaB] activation , respectively , as compared to wild type NEMO . Positive_regulation RELA TNF 18314102 1886048 We showed that overexpression of HDAC2 enhanced *induced* [NF-kappaB] activity and that silencing of HDAC2 decreased NF-kappaB activity . Positive_regulation RELA TNF 18331465 1925080 L. reuteri suppressed induced [NF-kappaB] *activation* , including NF-kappaB dependent reporter gene expression in a dose-and time dependent manner . Positive_regulation RELA TNF 18336259 1881560 Since *activates* [NF-kappaB] and AP-1 , we investigated the role of exogenous Nef protein in TNFalpha stimulated U937 cells and primary macrophages . Positive_regulation RELA TNF 18336259 1881563 We observed that exogenous Nef and synergistically *activate* [NF-kappaB] and AP-1 in U937 cells and primary macrophages resulting in enhanced stimulation of the HIV-1 long terminal repeat ( LTR ) , and subsequently in enhanced viral replication in both chronically infected promonocytic U1 cells and acutely HIV-1 infected primary macrophages . Positive_regulation RELA TNF 18336852 1912251 Furthermore , the involvement of NF-kappaB in TNF-alpha induced MMP-9 production was consistent with that *stimulated* degradation of IkappaB-alpha and translocation of [NF-kappaB] into the nucleus which were blocked by helenalin , but not by U0126 and SP600125 , revealed by immunofluorescence staining . Positive_regulation RELA TNF 18357389 1887726 The transactivation of *stimulated* [NF-kappaB] , AP-1 and Sp-1 were inhibited by U0126 and SB203580 treatment . Positive_regulation RELA TNF 18364436 1912777 We , for the first time , demonstrate that binding of staphylococcal enterotoxin B to MHC-II results in activation of TNF-alpha converting enzyme , epidermal growth factor receptor , p38MAPK , and [NF-kappaB] *inducing* biphasic production . Positive_regulation RELA TNF 18385532 1907114 DHMEQ suppressed *induced* [NF-kappaB] activation and partially ameliorated glucose stimulated insulin secretion in a dose dependent manner . Positive_regulation RELA TNF 18386252 1893153 In addition , AGR decreased induced *activation* of [NF-kappaB] . Positive_regulation RELA TNF 18393939 1913456 Finally , when endogenous [NF-kappaB] is *induced* by ( tumour necrosis factor alpha ) treatment , HIF-1alpha levels also change in an NF-kappaB dependent manner . Positive_regulation RELA TNF 18395009 1907236 While the nuclear recruitment of RelA by IRF-2 augments *induced* [NF-kappaB] dependent transcription , the N-terminal truncated mutant form of IRF-2 inhibits the nuclear localization of RelA , and thus interferes with NF-kappaB activation . Positive_regulation RELA TNF 18395009 1907238 Furthermore , the knockdown of IRF-2 by IRF-2 siRNA attenuates *induced* [NF-kappaB] dependent transcription by inhibiting the nuclear localization of RelA . Positive_regulation RELA TNF 18408586 1894020 receptor signaling was *required* for activation of [NF-kappaB] , but not for activation of activating protein 1 family members junD and Fra-1 in day 2 allografts . Positive_regulation RELA TNF 18433717 1915325 *caused* a rapid activation of [NF-kappaB] within 15min as evidenced by gel shift assay ( EMSA ) . Positive_regulation RELA TNF 18434384 1932531 Sevoflurane caused nuclear translocation of SMAD3 and reduced the *induced* nuclear translocation of [NF-kappaB] in primary cultures of proximal tubules from TGF-beta1+/+ but not in TGF-beta1+/- mice . Positive_regulation RELA TNF 18439578 1915602 A further analysis indicated that lycopene attenuated *induced* IkappaB phosphorylation , [NF-kappaB] expression , and NF-kappaB p65 translocation from cytosol to nucleus . Positive_regulation RELA TNF 18439578 1915604 In line with this , *induced* [NF-kappaB-DNA] but not AP1-DNA complexes formation was inhibited by lycopene , as determined by the electrophoretic mobility shift assay ( EMSA ) . Positive_regulation RELA TNF 18439578 1915610 Taken together , we provided here the first evidence showing that lycopene is able to inhibit induced [NF-kappaB] *activation* , ICAM-1 expression , and monocyte-endothelial interaction , suggesting an anti-inflammatory role of lycopene and possibly explaining in part why lycopene can prevent cardiovascular diseases . Positive_regulation RELA TNF 18442799 1900627 The protein synthesis inhibitor cycloheximide ( CHX ) and its structural derivative acetoxycycloheximide ( Ac-CHX ) have been recently shown to block the induced *activation* of [NF-kappaB] via ectodomain shedding of TNF receptor 1 (TNF-R1) in human lung carcinoma A549 cells . Positive_regulation RELA TNF 18442799 1900632 In this study , we show that ERK and p38 MAP kinase are involved in the downregulation of cell surface TNF-R1 upon exposure to Ac-CHX and the subsequent inhibition of *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 18442881 1938510 via TNFR1 axis *induces* [NFkappaB] , and may contribute to inflammation facilitated neoplasia . Positive_regulation RELA TNF 18444250 1984038 Betulinic acid suppresses constitutive and induced [NF-kappaB] *activation* and induces apoptosis in human prostate carcinoma PC-3 cells . Positive_regulation RELA TNF 18444250 1984056 BetA also inhibited induced *activation* of [NF-kappaB] via the IkappaBalpha pathway , thereby sensitizing the cells to TNFalpha induced apoptosis . Positive_regulation RELA TNF 18446055 1902766 Finally , pretreatment with pyrrolidine dithiocarbamate ( PDTC ) , an inhibitor of NF-kappaB , reduced TNF-alpha induced ICAM-1 expression and both DPI and RacN17 significantly diminished [NF-kappaB] activation in *response* to . Positive_regulation RELA TNF 18450452 1908445 CARP-2 is an endosome associated ubiquitin ligase for RIP and regulates induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 18450452 1908450 One important consequence of signaling is activation of the transcription factor NF-kappaB , and failure to downregulate *induced* [NF-kappaB] transcriptional activity results in chronic inflammation and death . Positive_regulation RELA TNF 18450452 1908452 We report that CARP-2 , a RING domain containing ubiquitin protein ligase (E3) , is a negative regulator of induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 18450452 1908456 CARP-2 acts at the level of endocytic vesicles to limit the intensity of induced [NF-kappaB] *activation* by the regulated elimination of a necessary signaling component within the receptor complex . Positive_regulation RELA TNF 18455514 1916054 On the other hand , cells preincubated with HMW adiponectin had reduced induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 18463678 1971660 Employing a series of in vitro and in cellulo approaches , we have demonstrated that in primary human keratinocytes ( i ) rapidly *induces* ROS generation , IkappaB degradation , [NF-kappaB] p65 nuclear translocation , and ultimately production of inflammatory cytokines ; Positive_regulation RELA TNF 18463678 1971663 ( iii ) dependent [NF-kappaB] *activation* ( that is , IkappaB degradation and NF-kappaB p65 nuclear translocation ) is not mediated by ROS ; Positive_regulation RELA TNF 18467203 1921437 EMSA showed that IL-1beta and *activated* [NF-kappaB] and AP-1 in MG-63 cells . Positive_regulation RELA TNF 18496506 1965453 The activation of [NF kappaB] and TNF-alpha synthesis *induced* by polymeric IgA or were downregulated by BMP-7 or rosiglitazone . Positive_regulation RELA TNF 18497946 1917527 The expression of CYLD and [NF-kappaB] mRNAs in HSG cells was *increased* by . Positive_regulation RELA TNF 18537100 1923355 HMW adiponectin requires a shorter incubation period to demonstrate inhibition against induced [NF-kappaB] *activation* , compared with gAd . Positive_regulation RELA TNF 18544535 1945804 The changes in TNFR self-association were functionally significant , because pretreating the HeLa cells and 293T cells resulted in increased *induced* [NF-kappaB] activation and TNF induced expression of IkappaB and syndecan-4 mRNA levels . Positive_regulation RELA TNF 18544535 1945806 Although pretreatment with DsbA did not result in an increase in TNF binding to TNFRs , it resulted in increased induced *activation* of [NF-kappaB] , consistent with an allosteric modification of the TNFRs . Positive_regulation RELA TNF 18550065 2010454 Niacin inhibited : ( a ) angiotensin II (ANG II) induced reactive oxygen species ( ROS ) production by 24-86 % , ( b ) low density lipoprotein (LDL) oxidation by 60 % , ( c ) induced [NF-kappaB] *activation* by 46 % , vascular cell adhesion molecule-1 ( VCAM-1 ) by 77-93 % , monocyte chemotactic protein-1 (MCP-1) secretion by 34-124 % , and ( d ) in a functional assay TNF-alpha induced monocyte adhesion to HAEC ( 41-54 % ) . Positive_regulation RELA TNF 18550789 1945941 Conversely , increasing tmTNF-alpha expression by suppressing expression of TNF-alpha converting enzyme that cleaves tmTNF-alpha led to an enhanced activation of NF-kappaB , indicating that tmTNF-alpha , but not , *contributes* to constitutive [NF-kappaB] activation . Positive_regulation RELA TNF 18562480 1946208 The data presented herein suggest a model whereby the TNF R1-IRAK-1 interaction integrates the cellular response to LPS , TNF-alpha , and IL-1 , culminating in a cell poised to activate *dependent* [NF-kappaB] controlled gene expression . Positive_regulation RELA TNF 18563354 1924236 EPS also prevented the *induced* nuclear translocation of [NF-kappaB] , one of the redox-sensitive transcription factors , in a concentration dependent manner . Positive_regulation RELA TNF 18563354 1924238 Taken together , our results suggest that the anti-oxidant components of EPS prevent induced [NF-kappaB] *activation* , chemokine induction , and monocyte adhesion at the site of intestinal inflammation . Positive_regulation RELA TNF 18564176 2010531 We also demonstrated inhibition of induced [NF-kappaB] *activation* in HUVEC treated with glimepiride , which was attenuated by pretreatment with N ( omega ) -nitro-L-arginine methyl ester . Positive_regulation RELA TNF 18565826 1929541 The functional significance of these results was stressed by the stimulation of [NF-kappaB] transcriptional activity , both basal and *stimulated* , induced by an E-cadherin siRNA . Positive_regulation RELA TNF 18566223 1929563 17-AJB effectively inhibited *induced* [NF-kappaB] activation and induced apoptosis of tumor cells . Positive_regulation RELA TNF 18566231 1929577 Pinitol also suppressed the [NF-kappaB] reporter activity *induced* by , TNFR associated death domain , TNFR associated factor-2 , transforming growth factor-beta activated kinase-1 ( TAK-1 ) /TAK1 binding protein-1 , and IkappaBalpha kinase but not that induced by p65 . Positive_regulation RELA TNF 18567808 1929756 As examined by DNA binding , we found that TQ suppressed *induced* [NF-kappa B] activation in a dose- and time dependent manner and inhibited NF-kappaB activation induced by various carcinogens and inflammatory stimuli . Positive_regulation RELA TNF 18569074 1929860 The cellular secretion of TNF-alpha , IL-1beta , IL-6 , NO and IL-10 in supernatant , mRNA expression of , COX-2 , iNOS and HO-1 , protein expression of COX-2 and HO-1 , and *activation* of [NF-kappaB] were assayed by ELISA , the Griess method , real-time quantitative PCR , and Western blot and immunocytochemistry method , respectively . Positive_regulation RELA TNF 18577376 1941006 Indeed , physalin B induced an increase in bioluminescence from DLD-1 4Ub-Luc cells , at concentrations also producing an accumulation of ubiquitinated proteins and inhibiting induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 18577686 1953007 The effective inhibition of *induced* [NF-kappaB] signaling by EF24 extends the therapeutic application of EF24 to other NF-kappaB dependent diseases , including inflammatory diseases such as rheumatoid arthritis . Positive_regulation RELA TNF 18579519 1953052 We recently showed that a novel disulfide reductase , TRP14 , inhibits induced [NF-kappaB] *activation* , and we identified the dynein light chain LC8 , which interacts with the NF-kappaB inhibitor IkappaBalpha , as a potential substrate of TRP14 . Positive_regulation RELA TNF 18579519 1953058 LC8 inhibited induced [NF-kappaB] *activation* in HeLa cells by interacting with IkappaBalpha and thereby preventing its phosphorylation by IkappaB kinase (IKK) , without affecting the activity of IKK itself . Positive_regulation RELA TNF 18582564 1946710 Insulin markedly increased induced [NF-kappaB] *activation* and induced phosphorylated IkappaB-alpha accumulation . Positive_regulation RELA TNF 18591962 1966115 Furthermore , Bcl-x ( L ) downregulation does not affect mediated [NF-kappaB] *activation* . Positive_regulation RELA TNF 18593997 1931541 In HNSCC cell lines , 10 ( -8 ) mol/L bortezomib inhibited cell density while inhibiting *induced* and partially inhibiting basal activation of NF-kappaB1/RELA , but not [NF-kappaB2/RELB] . Positive_regulation RELA TNF 18599158 2208616 and ( 3 ) S100B/RAGE induced upregulation of COX-2 , IL-1beta and expression *requires* the concurrent activation of [NF-kappaB] and AP-1 . Positive_regulation RELA TNF 18603781 1941620 cDNA microarray analysis revealed that EPQB decreased *induced* expression of [NF-kappaB] target genes . Positive_regulation RELA TNF 18606397 1984317 SH-5 also blocked [NF-kappaB] activation *induced* by , lipopolysaccharide , phorbol ester , and cigarette smoke but not that activated by hydrogen peroxide and RANK ligand , indicating differential requirement of AKT . Positive_regulation RELA TNF 18612822 2028037 Saccharomyces boulardii blocked tumor necrosis factor-alpha (TNF-alpha) regulation of PPAR-gamma and IL-8 through disruption of mediated [nuclear factor kappa B (NF-kappaB)] *activation* . Positive_regulation RELA TNF 18618239 2086019 We found that transfection of TNF-LS or wild-type containing LS constitutively *activated* [NF-kappaB] and conferred the cytotoxic resistance of MCF-7 cells , while transfection of a mutant tmTNF-alpha lacking the cytoplasmic segment of LS neither activated NF-kappaB nor affected the sensitivity . Positive_regulation RELA TNF 18618239 2086021 These results indicate that membrane anchored *contributes* to constitutive activation of [NF-kappaB] and resistance to sTNF-alpha induced cell death . Positive_regulation RELA TNF 18621737 1954338 c-IAP1 and c-IAP2 are critical mediators of induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 18621737 1954341 Both c-IAP1 and c-IAP2 have been implicated in *stimulated* [NF-kappaB] activation . Positive_regulation RELA TNF 18621737 1954349 Here we investigate the role of c-IAP1 and c-IAP2 in *stimulated* activation of [NF-kappaB] . Positive_regulation RELA TNF 18621737 1954357 We demonstrate that induced [NF-kappaB] *activation* is severely diminished in the absence of both c-IAP proteins . Positive_regulation RELA TNF 18621737 1954365 Therefore , c-IAP1 and c-IAP2 are required for *stimulated* RIP1 ubiquitination and [NF-kappaB] activation . Positive_regulation RELA TNF 18637177 1942042 We have used this technique to quantitatively characterize *activation* of the transcription factor [NF-kappaB] by the cytokine . Positive_regulation RELA TNF 18644347 1947734 Celecoxib potently inhibits induced nuclear translocation and *activation* of [NF-kappaB] . Positive_regulation RELA TNF 18644347 1947736 Here , we found that Celecoxib potently inhibited *induced* transcriptional activity and DNA binding activity of [NF-kappaB] ; Positive_regulation RELA TNF 18644347 1947747 Taken together , these data indicate that Celecoxib specifically inhibits induced [NF-kappaB] *activation* at the level of its nuclear translocation . Positive_regulation RELA TNF 18650791 1972741 Candesartan suppressed induced chemokine expression and [NFkappaB] *activation* independent of AT1R blockade in cultured renal tubular epithelial cells . Positive_regulation RELA TNF 18662886 1972999 *induced* rapid [NF-kappaB] activation in both HT-29 and FHC cell lines and this effect was differently modulated by NaBt in these two cell lines . Positive_regulation RELA TNF 18662886 1973001 In HT-29 cells , NaBt potentiated [NF-kappaB] activity *induced* by after 4h treatment . Positive_regulation RELA TNF 18662886 1973003 During additional time of TNF-alpha and NaBt co-treatment , NaBt decreased the *mediated* [NF-kappaB] activity in both cell types . Positive_regulation RELA TNF 18676814 1943475 Encoding [NF-kappaB] temporal control in *response* to : distinct roles for the negative regulators IkappaBalpha and A20 . Positive_regulation RELA TNF 18676814 1943479 *induced* [NF-kappaB] activity shows complex temporal regulation whose different phases lead to distinct gene expression programs . Positive_regulation RELA TNF 18683887 2020119 *induced* [NF-kappaB] signaling reverses age related declines in VEGF induction and angiogenic activity in intervertebral disc tissues . Positive_regulation RELA TNF 18687707 2011738 STAT5b knockdown in T84 CEC increased *dependent* [NF-kappaB] and caspase-3 activation . Positive_regulation RELA TNF 18697935 1950330 Both cIAP1 and cIAP2 regulate mediated [NF-kappaB] *activation* . Positive_regulation RELA TNF 18697935 1950340 The cellular inhibitor of apoptosis 1 and 2 ( cIAP1 and cIAP2 ) proteins have been implicated in the *activation* of [NF-kappaB] by ; however , genetic deletion of either cIAP1 or 2 did not support a physiologically relevant role , perhaps because of functional redundancy . Positive_regulation RELA TNF 18697935 1950342 Whereas [NF-kappaB] was properly *activated* by in cultured and primary cells deficient in either cIAP1 or 2 , removal of both cIAPs severely blunted its activation . Positive_regulation RELA TNF 18700741 1961357 2Alpha-hydroxyursolic acid is one of the major triterpenoids isolated from apple peels , and its effects on cell proliferation and *induced* [NF-kappaB] activation in MCF-7 cells were examined . Positive_regulation RELA TNF 18700741 1961359 Preincubation with 2alpha-hydroxyursolic acid suppressed induced [NF-kappaB] *activation* in a dose dependent manner and significantly inhibited the activation at a dose of 20 microM of 2alpha-hydroxyursolic acid ( p < 0.05 ) . Positive_regulation RELA TNF 18700741 1961363 These results suggest that 2alpha-hydroxyursolic acid has antiproliferative activities against MCF-7 cells and capabilities inhibiting [NF-kappaB] activation *induced* by partially by suppressing proteasome activities . Positive_regulation RELA TNF 18703532 2011803 Cilostazol also dose-dependently inhibited *induced* [NF-kappaB] activation and TNFalpha induced I kappa B kinase activity . Positive_regulation RELA TNF 18710428 2028210 As for the signalling pathway , stimulation *led* to the phosphorylation of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and p38 mitogen activated protein kinase ( p38MAPK ) and translocation of [nuclear factor kappaB (NF-kappaB)] ( p65 ) into the nuclei . Positive_regulation RELA TNF 18710428 2028241 These data suggest that interaction *leads* to the phosphorylation of Erk1/2 and p38MAPK and nuclear translocation of [NF-kappaB] , which is closely associated with the production and activation of MMP-9 in cultured CC cells of HuCTT-1 and CCKS-1 . Positive_regulation RELA TNF 18712050 1950680 Our data suggest a role for the Ras/mitogen activated protein kinase (MAPK) signaling pathway and the receptor *mediated* activation of [nuclear factor-kappaB (NF-kappaB)] in the etiology of cardiac enlargement in the HHR . Positive_regulation RELA TNF 18719026 1984930 We conclude the inhibitory effects of on GH-inducible promoter activity are *mediated* by [NFkappaB] , especially p65 , by a mechanism that does not require protein synthesis . Positive_regulation RELA TNF 18719121 1955796 In cells from TRADD-deficient mice , TNFalpha mediated apoptosis and *stimulated* [NF-kappaB] , JNK , and ERK activation are defective . Positive_regulation RELA TNF 18753141 1980022 *induced* the maximal S100A6 promoter and transcription factor [NF-kappaB] ( p65 subunit ) . Positive_regulation RELA TNF 18755269 1975308 GbetaL regulates *induced* [NF-kappaB] signaling by directly inhibiting the activation of IkappaB kinase . Positive_regulation RELA TNF 18755269 1975319 Overexpression of GbetaL inhibits induced *activation* of [NF-kappaB] signaling , while down-regulation of GbetaL expression by small interfering RNA enhances NF-kappaB activity . Positive_regulation RELA TNF 18755269 1975321 Taken together , these data suggest that GbetaL is involved in the negative regulation of *stimulated* [NF-kappaB] signaling through a direct interaction with IKK . Positive_regulation RELA TNF 18768892 1957246 Consistently , Nod2-null macrophages tolerant to LPS and MDP showed enhanced production of and IL-6 as well as increased [NF-kappaB] and MAPK *activation* in response to the dipeptide KF1B , the Nod1 agonist . Positive_regulation RELA TNF 18772349 2012053 Further , [NF-kappaB] *activation* by or p65 overexpression stimulates Shh promoter activity and p65 binds to Shh promoter in vivo . Positive_regulation RELA TNF 18779659 1963178 The stimulation of lymphoid cells with , IL-1beta , and LPS *resulted* in significant ROS production and [NF-kappaB] activation . Positive_regulation RELA TNF 18782567 1975928 The electromobility shift assay showed that while Cl1-0 cells exhibited low [NF-kappaB] activity in *response* to , an abundance of basal and TNF-alpha induced NF-kappaB-DNA complex was detected in Cl1-5 cells . Positive_regulation RELA TNF 18819888 1970310 To investigate the effect of rosiglitazone on the expression of [nuclear factor-kappaB (NF-kappaB)] and coupling factor 6 (CF6) *induced* by in cultured human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation RELA TNF 18824032 1987694 , which *activates* [NF-kappaB] , ameliorated alcohol induced cell death in nNOS-/- and wild-type cultures , while an NF-kappaB inhibitor (NFi) blocked the protective effects of TNF-alpha and worsened alcohol induced cell death . Positive_regulation RELA TNF 18830563 2000846 By using a natural stable folate we were able to reverse the EGCG suppression of *induced* [NF-kappaB] activation , the phosphorylation and degradation of IkappaBalpha and the phosphorylation of Akt in this human colon carcinoma cell line . Positive_regulation RELA TNF 18851874 2000881 Although both L153R and C417R impaired TLR and induced [NF-kappaB] *activation* , L153R also increased TNF-alpha induced programmed cell death with decreased A20 expression . Positive_regulation RELA TNF 18930133 2013550 PPM1A and PPM1B act as IKKbeta phosphatases to terminate *induced* [IKKbeta-NF-kappaB] activation . Positive_regulation RELA TNF 18930133 2013570 Furthermore , knockdown of PPM1A and PPM1B expression enhances *induced* IKKbeta phosphorylation , [NF-kappaB] nuclear translocation and NF-kappaB dependent gene expression . Positive_regulation RELA TNF 18930133 2013572 These data suggest that PPM1A and PPM1B play an important role in the termination of mediated [NF-kappaB] *activation* through dephosphorylating and inactivating IKKbeta . Positive_regulation RELA TNF 18948189 2014100 The data showed that , unlike transient oxidative stress , sustained exposure of HLEC to physiologically relevant levels of H ( 2 ) O ( 2 ) ( 50-100 microM for 4 h ) did not induce the degradation of I-kappaB and activation of NF-kappaB , but attenuated induced degradation of I-kappaB and *activation* of [NF-kappaB] . Positive_regulation RELA TNF 18948189 2014102 Consistent with the role of the proteasome in degradation of I-kappaB and activation of NF-kappaB , treatment of HLEC with proteasome inhibitors also attenuated induced I-kappaB degradation and [NF-kappaB] *activation* . Positive_regulation RELA TNF 18948191 1982311 In conclusion , The and IL-6 signals from the blood are necessary for liver regeneration and [NF-kappaB] and STAT3 binding are *activated* via TNF-alpha and IL-6 signal pathways . Positive_regulation RELA TNF 18948845 2053227 Hypertonic saline attenuates *induced* [NF-kappaB] activation in pulmonary epithelial cells . Positive_regulation RELA TNF 18948845 2053229 We hypothesized that HTS would inhibit *induced* [nuclear factor (NF)-kappaB] proinflammatory signaling in pulmonary epithelial cells . Positive_regulation RELA TNF 18948845 2053232 Hypertonic saline significantly reduced *induced* intercellular adhesion molecule 1 levels and [NF-kappaB] nuclear localization . Positive_regulation RELA TNF 18948845 2053249 These results show that HTS inhibits induced [NF-kappaB] *activation* in the pulmonary epithelium and , further , our understanding of its beneficial effects in hemorrhage induced ALI . Positive_regulation RELA TNF 18952128 2021606 The zinc finger containing protein A20 is a negative regulator of *induced* JNK ( c-Jun-N-terminal kinase ) and [NFkappaB] ( nuclear factor kappaB ) signaling . Positive_regulation RELA TNF 18952368 2014715 Sulforaphane suppresses *mediated* activation of [NF-kappaB] and induces apoptosis through activation of reactive oxygen species dependent caspase-3 . Positive_regulation RELA TNF 18952368 2014717 We also report that SFN non-specifically inhibited induced [NF-kappaB] *activation* through the inhibition of IkappaBalpha phosphorylation , IkappaBalpha degradation , and p65 nuclear translocation . Positive_regulation RELA TNF 18952368 2014721 These effects suggest that SFN inhibits induced [NF-kappaB] *activation* through the suppression of IkappaBalpha degradation , leading to reduced expression of NF-kappaB regulated gene products . Positive_regulation RELA TNF 18952368 2014729 In conclusion , the results of the present study indicate that SFN suppresses *induced* [NF-kappaB] activity and induces apoptosis through activation of ROS dependent caspase-3 . Positive_regulation RELA TNF 18974130 1983027 Electrophoretic mobility shift assay showed that pretreatment with picroliv abrogated *induced* activation of [NF-kappaB] . Positive_regulation RELA TNF 18975348 1983213 Inhibition of ROK by specific inhibitors or ROK small interfering RNA suppressed lipopolysaccharide- or *induced* [NF-kappaB] nuclear translocation , DNA binding activity , luciferase reporter gene expression , and IkappaBalpha degradation . Positive_regulation RELA TNF 18981572 1983616 Furthermore , Rb1 inhibited *induced* MAPKs and [NF-kappaB] activation . Positive_regulation RELA TNF 18988888 2015885 Adenovirus mediated overexpression of AdipoR1 and 2 in ECs significantly enhanced the suppressive effect of a subeffective dose of adiponectin on induced ICAM-1 expression and [NF-kappaB] *activation* . Positive_regulation RELA TNF 18990707 2015903 Expression of a PKCdelta-T505A mutant suppressed the thrombin induced but not the *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 18996370 2016019 Inhibition of NF-kappaB activity by short interfering RNA mediated knock-down of p65 impairs , while *activation* of [NF-kappaB] activity by synergizes induction of NF-kappaB target genes by LMX1B . Positive_regulation RELA TNF 19004544 2022203 It has been found that a short cell-permeable peptide spanning the IKK-beta NBD , named NBD peptide , disrupted the association of NEMO with IKKs in vitro and blocked *induced* [NF-kappaB] activation in vivo . Positive_regulation RELA TNF 19019947 2022578 We report here that the nucleocapsid ( N ) protein of HTNV was able to inhibit induced *activation* of [NF-kappaB] , as measured by a reporter assay , and the activation of endogenous p65 , an NF-kappaB subunit . Positive_regulation RELA TNF 19023456 2001485 induced *activation* of [NFkappaB] protects against UV-induced apoptosis specifically in p53-proficient cells . Positive_regulation RELA TNF 19028529 2053487 Treatment with 50 microM of Ser-Ser-Ser and Glu-Glu-Glu , but not Val-Pro-Leu caused an inhibition of *induced* activation of [NF-kappaB] compared to control cells ( P < 0.05 ) . Positive_regulation RELA TNF 19033441 2022957 Functional complementation assays and in vivo pull-down experiments further show that ZF residues involved in ubiquitin binding are functionally important and required for [NF-kappaB] signaling in *response* to . Positive_regulation RELA TNF 1905804 161661 Our results suggest that maximal transcriptional activation of the uPA gene by PMA , IL-1 and *requires* the induction of [NFkB] activity and the decay of a short lived repressor protein , possibly IkB . Positive_regulation RELA TNF 19063961 2030172 [NF-kappaB] DNA binding activity was *increased* by alone but lowered by TNFalpha plus PY . Positive_regulation RELA TNF 19065580 2053578 Furthermore , enniatins A1 and B1 , but not enniatin B were able to inhibit moderately *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 19067146 2024087 The TNBS treatment caused colon shortening , increased myeloperoxidase activity , *induced* IL-1beta , , and IL-6 expression in the colon , activated [NF-kappaB] , and potentiated the GAG degrading activities of intestinal microflora . Positive_regulation RELA TNF 19091594 2031044 TRAF6 negatively regulates *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 19091594 2031053 Also , *induced* DNA binding activity and transcriptional activation of [nuclear factor kappaB (NF-kappaB)] were also augmented in TRAF6-deficient MEFs . Positive_regulation RELA TNF 19091594 2031058 Moreover , the reintroduction of exogenous TRAF6 into TRAF6-deficient MEFs clearly suppressed induced IKK activation , [NF-kappaB] *activation* and subsequent cytokine expression . Positive_regulation RELA TNF 19091594 2031064 Thus , these data suggest that TRAF6 negatively regulates induced [NF-kappaB] *activation* through its ubiquitin ligase activity . Positive_regulation RELA TNF 19098937 2018727 *induced* [NF-kappaB] activation was determined using a reporter gene assay . Positive_regulation RELA TNF 19098937 2018729 TA-35 ( 1-20 micromol/L ) suppressed induced [NF-kappaB] *activation* in transfected cells ( HEK293/pNiFty-SEAP ) in a dose- ( 1-20 micromol/L ) and time dependent ( 0-48 h ) manner . Positive_regulation RELA TNF 19098937 2018731 Subsequently , both NF-kappaB p65 and its inhibitor IkappaB gradually accumulated in cytoplasmic extracts in a dose- and time dependent manner , indicating the blockage of [NF-kappaB] translocation *induced* by from the cytoplasm to the nucleus . Positive_regulation RELA TNF 19104039 2004121 In models of physiologic [NF-kappaB] pathway *activation* by CARD11 or , compensatory IKKalpha activity was also observed with IKKbeta inhibition . Positive_regulation RELA TNF 19113817 2127672 Cellular stimulation by induced NADPH dependent superoxide production in the endosomal compartment , and this ROS was *required* for IKK mediated activation of [NF-kappaB] . Positive_regulation RELA TNF 19113817 2127677 Inhibiting endocytosis reduced the ability of to *induce* both NADPH dependent endosomal superoxide and [NF-kappaB] , supporting the notion that redox dependent signaling of the receptor occurs in the endosome . Positive_regulation RELA TNF 19131965 2042498 Furthermore , RNF11 was required for A20 to interact with and inactivate RIP1 to inhibit mediated [NF-kappaB] *activation* . Positive_regulation RELA TNF 19138739 2037801 ELISA showed that pretreatment with 1alpha,25- ( OH ) ( 2 ) D ( 3 ) significantly inhibited the induced [NF-kappaB] *activation* in HCAEC . Positive_regulation RELA TNF 19144181 2079140 *induced* regulation of Sox9 and [NFkappaB] activity was also U0126 insensitive . Positive_regulation RELA TNF 19147572 2026423 At a dose of 100 micromol/L , EGCG abrogates p300 induced p65 acetylation in vitro and in vivo , increases the level of cytosolic IkappaBalpha , and suppresses *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 19148557 2026688 To examine whether estrogen and/or genistein regulate osteoblast differentiation by modulating the NF-kappaB pathway , we examined the effect of 17beta-estradiol and genistein on basal and *stimulated* [NF-kappaB] activity in the preosteoblastic cell line MC3T3 . Positive_regulation RELA TNF 19148557 2026690 Our data reveal that while 17beta-estradiol had no effect on basal NF-kappaB activity in MC3T3 cells , it significantly antagonized [NF-kappaB] activity *induced* by ( 1 or 10 ng/ml ) . Positive_regulation RELA TNF 19148557 2026692 By contrast , genistein ( 10 ( -6 ) or 10 ( -5 ) M ) significantly increased NF-kappaB activity , and showed no antagonistic effects on *induced* [NF-kappaB] promoter activity . Positive_regulation RELA TNF 19148557 2026694 While 17beta-estradiol may stimulate bone anabolism , in part , by antagonizing induced [NF-kappaB] *activation* , genistein not only fails to prevent cytokine induced NF-kappaB activation , but directly promotes NF-kappaB activation in MC3T3 cells . Positive_regulation RELA TNF 19151401 2079188 PolyI : C , flagellin , or also *induced* [NF-kappaB] p65 protein nuclear translocation . Positive_regulation RELA TNF 19152372 2093397 Both S-containing dimeric withanolides , 1 and 2 , completely suppressed *induced* [NF-kappaB] activation when tested at 100 microm . Positive_regulation RELA TNF 19152372 2093399 In addition , this is the first report on the abrogation of induced [NF-kappaB] *activation* for compounds 1 and 2 . Positive_regulation RELA TNF 19158250 2043317 For example , the molluscum contagiosum virus MC160 protein inhibits induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 19158250 2043320 Since cells expressing either the N or C mutant MC160 protein remained similarly resistant to induced [NF-kappaB] *activation* , the N mutant protein probably utilized a different mechanism for inhibiting NF-kappaB . Positive_regulation RELA TNF 19181934 2043846 IL-10 attenuates induced [NF kappaB] pathway *activation* and cardiomyocyte apoptosis . Positive_regulation RELA TNF 19181934 2043865 Inhibition of ERK 1/2 MAPK with PD98059 attenuated the protective role of IL-10 against *induced* activation of IKK and [NF kappaB] as well as cardiomyocyte apoptosis . Positive_regulation RELA TNF 19181934 2043869 IL-10 prevents induced [NF kappaB] *activation* and pro-apoptotic changes in cardiomyocytes by inhibiting IKK phosphorylation through the activation of ERK 1/2 MAPK . Positive_regulation RELA TNF 19183881 2033287 Moreover , ACK significantly suppressed *induced* translocation of redox-sensitive [nuclear factor (NF)-kappaB] as well as degradation of cytosolic I-kappaBalpha . Positive_regulation RELA TNF 19199007 2049724 Phosphorylation on Thr-106 and NO-modification of glyoxalase I suppress the *induced* transcriptional activity of [NF-kappaB] . Positive_regulation RELA TNF 19199007 2049728 Furthermore , we investigated the role of NO-mediated modification and phosphorylation of GLO1 in the *induced* transcriptional activity of [NF-kappaB] . Positive_regulation RELA TNF 19199007 2049730 Suppression of the basal and *induced* [NF-kappaB] activity was significantly stronger upon expression of a GLO1 mutant that was either deficient for the NO-mediated modification or phosphorylation on Thr-106 . Positive_regulation RELA TNF 19199007 2049732 However , upon overexpression of a GLO1 mutant that was deficient for both types of modification , the suppressive effect of GLO1 on *induced* [NF-kappaB] activity was completely abolished . Positive_regulation RELA TNF 19199007 2049736 These findings suggest that phosphorylation and NO-modification of glyoxalase I provides another control mechanism for modulating the basal and *induced* expression of [NF-kappaB-responsive] genes . Positive_regulation RELA TNF 19201747 2033788 Glial activation markers such as macrophage antigen complex-1 ( Mac-1 , OX-42 ) and glial fibrillary acidic protein (GFAP) , production of , interleukin (IL)-1beta , and IL-10 , as well as [nuclear factor-kappa B (NF-kappaB)] *activation* were determined in the lumbar spinal cord . Positive_regulation RELA TNF 19233127 2050548 In addition , chrysin inhibited induced *activation* of [NF-kappaB] in IEC-6 cells . Positive_regulation RELA TNF 19243468 2240657 We report here that HSP70 over-expression in human colon cancer cells can inhibit induced [NFkappaB] *activation* but promote TNFalpha induced activation of c-Jun N-terminal kinase (JNK) through interaction with TNF receptor (TNFR) associated factor 2 ( TRAF2 ) . Positive_regulation RELA TNF 19243468 2240661 Therefore , our study suggests that HSP70 may differentially regulate induced *activation* of [NFkappaB] and JNK through interaction with TRAF2 , contributing to the pro-apoptotic roles of HSP70 in TNFalpha induced apoptosis of human colon cancer cells . Positive_regulation RELA TNF 19249288 2050971 Hydrogen-rich saline treatment decreased the neutrophil infiltration , the lipid membrane peroxidation , [NF-kappaB] *activation* and the pro-inflammatory cytokine interleukin IL-1beta and in the lung tissues compared with those in saline treated rat . Positive_regulation RELA TNF 19255345 2045185 In H9c2 cardiomyocytes , sustained NF-kappaB activation was proapoptotic , an effect dependent on TNFR1 signaling , whereas TNFR2 overexpression attenuated *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 19262565 2062985 Lysine methyltransferase Set9 physically associates with [RelA] in vitro and in vivo in *response* to stimulation . Positive_regulation RELA TNF 19262565 2062991 Depletion of Set9 by siRNA or mutation of the RelA methylation sites prolongs DNA binding of NF-kappaB and enhances *induced* expression of [NF-kappaB] target genes . Positive_regulation RELA TNF 19265173 2157100 Although these agonists did not induce significant IL-8 gene expression by these cells , they markedly enhanced *induced* [NF-kappaB] activation , resulting in increased IL-8 expression and release . Positive_regulation RELA TNF 19273093 2045772 By employing TNF-alpha / IFN-gamma synergism model which causes beta -cell apoptosis , we found that the antiapoptotic X-linked inhibitor of apoptosis (XIAP) molecule is upregulated by [NF-kappaB] in *response* to and XIAP induction was inhibited by IFN-gamma induced signal transducer and activator of transcription-1 ( STAT1 ) activation , which explains the death of beta -cells by TNF-alpha /IFN-gamma synergism . Positive_regulation RELA TNF 19273239 2045832 *Activation* of [nuclear factor kappa B (NF-kappa B)] by , up-regulates the expression of molecules which are involved in inflammation and cell adhesion . Positive_regulation RELA TNF 19274442 2072834 Pep 3 ( LRENECVS ) which was derived from the hydrophilic region of A1 module in CRD4 remarkably inhibited the binding of TNF-alpha to TNF-R1 , and also reversed *induced* degradation of IkappaB-alpha and nuclear translocation of [NF-kappaB] p65 subunit in HeLa cells . Positive_regulation RELA TNF 19277846 2106030 Sulforaphane had no effect on induced NF-kappaB nuclear binding activity , IkappaB-alpha degradation or *activation* of [NF-kappaB-driven] transcriptional activity . Positive_regulation RELA TNF 19284655 2055713 Moreover , the inhibitory effect of L-norvaline was not reversed by the NOS inhibitor L-NAME and L-norvaline did not interfere with induced *activation* of [NF-kappaB] , JNK , p38mapk , while it inhibited p70s6k ( S6K1 ) activity . Positive_regulation RELA TNF 19284955 2046502 ( 1 microg/L ) strongly *induced* the expression of [NF-kappaB] by approximately 1.76-fold compared with the control in the nuclei of A549 cells , and the induced NF-kappaB expression was significantly suppressed by addition of Feiyanning ( P < 0.01 ) . Positive_regulation RELA TNF 19284955 2046504 Feiyanning Decoction can markedly inhibit human lung cancer A549 cell proliferation , which may be partly due to inhibition of [NF-kappaB] activation *induced* by . Positive_regulation RELA TNF 19289468 2073006 We investigated the physiological role of endogenous MAPK activating death domain containing protein ( MADD ) , a splice variant of the IG20 gene , that can interact with TNFR1 in induced *activation* of [NF-kappaB] , MAPK , ERK1/2 , JNK , and p38 . Positive_regulation RELA TNF 19303852 2052125 Residues of NEMO involved in binding linear ubiquitin chains are required for [NF-kappaB] *activation* by and other agonists , providing an explanation for the detrimental effect of NEMO mutations in patients suffering from X-linked ectodermal dysplasia and immunodeficiency . Positive_regulation RELA TNF 19325144 2080383 activation of siDHCR24 treated cells *increased* expression of VCAM-1 ( 550-fold , P < 0.001 ) and [NF-kappaB] ( 9-fold , P < 0.001 ) that could no longer be suppressed by rHDLs . Positive_regulation RELA TNF 19336568 2056505 Tumor necrosis factor (TNF) receptor associated factor 2 ( TRAF2 ) is an adaptor protein that modulates the activation of the c-Jun NH ( 2 ) terminal kinase ( JNK ) /c-Jun and IkappaB kinase [(IKK)/nuclear factor-kappaB (NF-kappaB)] signaling cascades in *response* to stimulation . Positive_regulation RELA TNF 19340308 2056721 Overexpressed optineurin partly inhibited induced [NF-kappaB] *activation* in Hela cells . Positive_regulation RELA TNF 19340308 2056727 In addition these results suggest that there is a negative feedback loop in which *induced* [NF-kappaB] activity mediates expression of optineurin , which itself functions as a negative regulator of NF-kappaB . Positive_regulation RELA TNF 19347279 2057480 We describe in this chapter three separate methods to determine the effects of this NEMO binding domain (NBD) peptide on pro-inflammatory [NF-kappaB] signaling in *response* to . Positive_regulation RELA TNF 19347944 2057507 induced *activation* of [NF-kappaB] is not altered by 810 nm radiation using 25 J/cm ( 2 ) . Positive_regulation RELA TNF 19367378 2081655 These results suggest that Klotho suppresses induced expression of adhesion molecules and [NF-kappaB] *activation* . Positive_regulation RELA TNF 19369349 2089007 PKR dependent activation of p38 and NF-kappaB was required for vaccinia virus induced INHBA expression , whereas induction of *required* only PKR dependent [NF-kappaB] activation . Positive_regulation RELA TNF 19372735 2074671 We quantitatively compared the efficacy of various proteasome inhibitors ( MG132 , lactacystin and epoxomicin ) and IKK inhibitors ( BAY 11-7082 and PS1145 ) to block [NFkappaB] activity *induced* by or TPA and to sensitize LNCaP prostate carcinoma cells to apoptosis . Positive_regulation RELA TNF 19376732 2081873 Although *increased* DNA binding activity of Ref-1 regulated transcription factors , AP-1 and [NF-kappaB] , to the IL-8 promoter , promoter activity was mainly mediated by NF-kappaB binding . Positive_regulation RELA TNF 19376732 2081883 Silencing of Ref-1 in AGS cells inhibited basal and *induced* AP-1 and [NF-kappaB] DNA binding activity , but not their nuclear accumulation . Positive_regulation RELA TNF 19379593 2065656 It is concluded that the *induces* expressions of IL-8 mRNA , MCP-1 mRNA and [NF-kappaB] in HUVECs , and NF-kappaB activities signal pathway may play a role in IL-8 mRNA and MCP-1 mRNA expressions . Positive_regulation RELA TNF 19383900 2066099 Gel shift for induced hiNOS [NF-kappaB] *activation* showed decreased p50 binding and decreased NF-kappaB reporter activity in the beta-catenin-mutant HAbeta18 cells . Positive_regulation RELA TNF 19383900 2066110 Furthermore , SW480 cells stably transformed with wild-type adenomatous polyposis coli showed decreased beta-catenin protein and increased *induced* p65 [NF-kappaB] binding as well as iNOS and Traf1 expression . Positive_regulation RELA TNF 19393729 2094982 Furthermore , Cardiospermum halicacabum L. ethanol extract inhibited the *induced* DNA binding activity of [NF-kappaB] , which was associated with decreased p65 protein level in the nucleus in Jurkat cells . Positive_regulation RELA TNF 19403345 2157165 However , induced *activation* of [NF-kappaB] was not affected by over activated Notch-1 . Positive_regulation RELA TNF 19404960 2075183 Inhibition of Mcl-1 by EGCG triggered caspase 3 activity in RA synovial fibroblasts , which was mediated via down-regulation of the *induced* Akt and [NF-kappaB] pathways . Positive_regulation RELA TNF 19407978 2070818 These inhibitory actions of CLT were , at least in part , attributable to the inhibition of redox sensitive NF-kappaB activation , as CLT inhibited *induced* ROS generation as well as [NF-kappaB] nuclear translocation and activation in HT29 cells . Positive_regulation RELA TNF 19409903 2082513 Currently , *induced* [NF-kappaB] activation is believed to be impaired in TRAF2 and TRAF5 double knockout ( T2/5 DKO ) cells . Positive_regulation RELA TNF 19411063 2070950 Wu et al. , in this issue of Cancer Cell , show that dependent [NFkappaB] *activation* induces COP9 signalosome mediated inhibition of GSK3beta and the SCF(beta-TRCP) ubiquitin ligase , thus leading to stabilization of the transcription factor Snail and promoting cell migration and metastasis . Positive_regulation RELA TNF 19420112 2106636 Specific inhibitors of caspases-8 and -3 , but not of caspase-1 , reduced *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 19420112 2106643 Consistent with this , MLC kinase (MLCK) inhibitor ML-7 reduced *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 19434100 2090352 The TRADD-TRAF2-NIK-IKKalpha/beta signaling cascade , which plays an essential role in induced [NF-kappaB] *activation* , was found to be involved in tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) receptor mediated signal transduction . Positive_regulation RELA TNF 19444283 2114792 In this study , we found that p53 upregulated modulator of apoptosis ( PUMA ) , a p53 downstream target and a BH3-only Bcl-2 family member , is directly regulated by [NF-kappaB] in *response* to . Positive_regulation RELA TNF 19445900 2115286 The inhibition of *induced* [NF-kappaB] activation by marine natural products . Positive_regulation RELA TNF 19445900 2115290 Results obtained show that selected purified compounds had a cytotoxic effect on the human leukaemia cell line K562 , inhibited both *induced* [NF-kappaB-DNA] binding as well as TNF-alpha induced IkappaBalpha degradation and nuclear translocation of p50/p65 . Positive_regulation RELA TNF 19458540 2084698 These data indicate that *mediates* rapid activation of injury induced [NF-kappaB] DNA binding in Schwann cells and that these events are associated with inhibition of postinjury axonal sprouting . Positive_regulation RELA TNF 19464389 2101876 Hirsutenone , dexamethasone , cyclosporin A and Bay 11-7085 inhibited the *induced* phosphorylation of inhibitory kappaB and the activation of [nuclear factor (NF)-kappaB] . Positive_regulation RELA TNF 19464428 2084964 Overexpression of ABINs inhibits [NF-kappaB] *activation* by and several other stimuli . Positive_regulation RELA TNF 19465513 2107387 DMF inhibited *induced* NF-kappaB p65 phosphorylation , NF-kappaB nuclear entry , and [NF-kappaB-DNA] complex formation , whereas PDGF-BB appeared not to activate NF-kappaB within 60 min . Positive_regulation RELA TNF 19472212 2102255 Of note , *induced* [NF-kappaB] may be the primary pathway contributing to CXCL10 production in THP-1 cells . Positive_regulation RELA TNF 19500694 2102962 The results showed that EM inhibited *induced* expressions of RANKL and [NF-kappaB] at both mRNA and protein levels in a concentration dependent manner . Positive_regulation RELA TNF 19509265 2092235 In addition , although SMC3 dramatically reduced c-IAP1 level , it had marginal effect on c-IAP2 expression , induced RIP modification , [NF-kappaB] *activation* , and downstream antiapoptosis NF-kappaB target expression . Positive_regulation RELA TNF 19521662 2108938 Overexpression of WDR34 inhibited IL-1beta- , polyI : C- and lipopolysaccharide (LPS) induced but not *induced* [NF-kappaB] activation , whereas knockdown of WDR34 by a RNA-interference construct potentiated NF-kappaB activation by these ligands . Positive_regulation RELA TNF 19528257 2142366 Previous work , in nonmuscle cells , has shown that Hsp27 inhibits induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 19533666 2109651 induced [NF-kappaB] *activation* enhances cellular mechanisms including proliferation , migration , and invasion . Positive_regulation RELA TNF 19533666 2109654 However , it is unclear whether KiSS1 regulates induced [NF-kappaB] *activation* and further tumor cell migration . Positive_regulation RELA TNF 19533666 2109661 Both KiSS1 overexpression and KP10 ( kisspeptin-10 ) stimulation inhibited *induced* [NF-kappaB] activity , suppressed TNFalpha induced cell migration and cell attachment to fibronectin in breast cancer cells while KP10 has little effect on cancer cell proliferation . Positive_regulation RELA TNF 19533666 2109666 Therefore , our data demonstrate that KiSS1 inhibits induced [NF-kappaB] *activation* via downregulation of RhoA activation and suppression of breast cancer cell migration and invasion . Positive_regulation RELA TNF 19533738 2149494 A thorough screening of the signaling system confirmed that stimulation *up-regulated* [nuclear factor kappaB (NFkappaB)] signaling in SV-HCECs . Positive_regulation RELA TNF 19557502 2157508 Here , we report that overexpression of RIOK3 inhibits *induced* [NF-kappaB] activation , but down-regulation of endogenous RIOK3 expression by siRNA potentiates it . Positive_regulation RELA TNF 19558496 2202629 Furthermore , SFN elevated cellular glutathione levels and antagonized *induced* [NFkappaB] transactivation . Positive_regulation RELA TNF 19559672 2110582 In addition , *increased* [nuclear factor-kappa B (NF-kappaB)] activity in NK cells and inhibition of NF-kappaB impeded TNF-alpha enhanced NK cell maturation . Positive_regulation RELA TNF 19563733 2122001 EZS inhibited [NF-kappaB] activation and IkappaB-alpha phosphorylation *induced* by , subsequent degradation of IkappaB-alpha . Positive_regulation RELA TNF 19572372 2185608 In HEK293 cells , pretreatment with RvE1 inhibited *induced* nuclear translocation of [NF-kappaB] in a ChemR23 dependent manner . Positive_regulation RELA TNF 19576177 2111564 PGG significantly inhibited induced [NF-kappaB] *activation* as well as STAT1 activation . Positive_regulation RELA TNF 19587216 2142602 [NF-kappaB] *activation* by or hydrogen peroxide was FAK independent . Positive_regulation RELA TNF 19590508 2130059 Telmisartan caused a dose dependent suppression of the induced *activation* of [nuclear factor (NF)-kappaB] in vascular endothelial cells in this study . Positive_regulation RELA TNF 19590508 2130061 The thiazolidinediones neither influenced induced [NF-kappaB] *activation* nor influenced the inhibitory effect of telmisartan in this process . Positive_regulation RELA TNF 19592502 2137138 Here , we found that licochalcone A strongly inhibited tumor necrosis ( *induced* nuclear localization , DNA binding activity , and the transcriptional activity of [nuclear factor-kappaB (NF-kappaB)] . Positive_regulation RELA TNF 19592502 2137144 In contrast , a structurally related compound , echinatin , failed to inhibit *induced* IKK activation and [NF-kappaB] activation , suggesting that the 1,1-dimethy-2-propenyl group in licochalcone A is important for the inhibition of NF-kappaB . Positive_regulation RELA TNF 19594939 2111993 It could be demonstrated that the exogenous application of PC inhibits membrane dependent actin assembly and induced nuclear [NF-kappaB] *activation* . Positive_regulation RELA TNF 19594939 2111995 We analysed *induced* [NF-kappaB-activation] via the transient expression of a NF-kappaB-luciferase reporter system . Positive_regulation RELA TNF 19596085 2122921 Since NF-kappaB is an important therapeutic target , we decided to utilize an in vitro screening assay to identify potential inhibitors that block *induced* [NF-kappaB] activation in a C2C12 muscle line stably expressing an NF-kappaB luciferase reporter gene . Positive_regulation RELA TNF 19596777 2122952 While activation of NF-kappaB was essential for heat inactivated S. aureus induced and NO , inhibiting GSK-3beta blocked heat inactivated S. aureus *induced* [NF-kappaB] p65 nuclear translocation . Positive_regulation RELA TNF 19617655 2112466 In addition , propionate significantly inhibited the *induced* activation of [nuclear factor-kappa B (NF-kappaB)] and significantly increased the expression of peroxisome proliferator activated receptor alpha ( PPARalpha ) in HUVEC . Positive_regulation RELA TNF 19619938 2194989 Rosmarinic acid sensitizes cell death through suppression of induced [NF-kappaB] *activation* and ROS generation in human leukemia U937 cells . Positive_regulation RELA TNF 19619938 2194991 Rosmarinic acid ( RA ) , a naturally occurring polyphenol flavonoid , has been reported to inhibit induced [NF-kappaB] *activation* in human dermal fibroblasts . Positive_regulation RELA TNF 19619938 2194994 These results demonstrated that RA inhibits induced ROS generation and [NF-kappaB] *activation* , and enhances TNF-alpha induced apoptosis . Positive_regulation RELA TNF 19620837 2131216 treatment *induced* an elevated activated [NFkappaB/p65] , concomitant with induced p21 levels , which resulted in increased sensitivity to gefitinib in PC-9-ZD cells . Positive_regulation RELA TNF 19628032 2149917 TRP14 inhibits the induced [NF-kappaB] *activation* to a greater extent than Trx1 . Positive_regulation RELA TNF 19643162 2132353 Furthermore , SOCS-3 repressed *induced* degradation of IkappaB , [NFkappaB] DNA binding and transcription of the NFkappaB dependent MnSOD promoter . Positive_regulation RELA TNF 19652376 2118978 CA attenuated *induced* IkappaB degradation and [NF-kappaB] translocation from cytosol to the nucleus . Positive_regulation RELA TNF 19652376 2118980 In conclusion , *induced* [NF-kappaB-DNA] complex formation was inhibited by CA. CA reduced TNF-alpha induced endothelial adhesiveness to HUVECs by inhibiting transcription factor activation , and CAMs expression suggesting its potential role in atherosclerosis diseases . Positive_regulation RELA TNF 19660542 2138629 Furthermore , prefeeding LGG prevented induced intestinal [NF-kappaB] *activation* . Positive_regulation RELA TNF 19666475 2144053 NEMO and IKKbeta are essential for induced [NF-kappaB] *activation* , and we recently demonstrated that NEMO and IKKalpha are sufficient for interleukin (IL)-1 induced signaling . Positive_regulation RELA TNF 19689081 2126521 The results suggested LPS might activate [NF-kappaB] in peritoneal macrophages and *induce* the increase of transcription and expression of , IL-1beta , IL-6 genes ; Positive_regulation RELA TNF 19706600 2151480 *induces* [RelA] degradation via ubiquitination at lysine 195 to prevent excessive nuclear factor-kappaB activation . Positive_regulation RELA TNF 19706600 2151482 Here we report that tumor necrosis factor-alpha (TNFalpha) induces RelA polyubiquitination at the lysine 195 residue , and this ubiquitination event is critical for the degradation of RelA and termination of mediated [NF-kappaB] *activation* . Positive_regulation RELA TNF 19706600 2151487 Our finding is the first report that substitution of a key RelA lysine residue with arginine inhibits TNFalpha induced RelA ubiquitination and enhances *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 19710421 2144809 Restoration of importin alpha3 levels sustained [NF-kappaB] *activation* by during PHB transfection . Positive_regulation RELA TNF 19711042 2127346 Hepatitis delta virus large antigen sensitizes to *induced* [NF-kappaB] signaling . Positive_regulation RELA TNF 19711042 2127348 In this study , we demonstrated that *induced* [NF-kappaB] transcriptional activation was increased by LHDAg but not by SHDAg in both HEK293 and Huh7 cells . Positive_regulation RELA TNF 19714766 2202729 In response to apically applied natural commensal-origin DNA , polarized HT-29 and T84 cells enhanced expression of TLR9 in a specific manner , which was subsequently associated with attenuation of induced [NF-kappaB] *activation* and NF-kappaB mediated IL-8 expression . Positive_regulation RELA TNF 19726342 2134032 *induced* the activation of [NF-kappaB] and increased the expressions of IL-6 and sICAM-1 in HUVECs . Positive_regulation RELA TNF 19735646 2183313 When examined by electrophoretic gel shift mobility assay , curcumin ( NP ) was more active than curcumin in inhibiting induced [NF-kappaB] *activation* and in suppression of NF-kappaB regulated proteins involved in cell proliferation ( cyclin D1 ) , invasion ( MMP-9 ) , and angiogenesis ( VEGF ) . Positive_regulation RELA TNF 19739098 2163233 Based on our previous observations that the nutrient flavonoid luteolin potently blocks induced [NF-kappaB] *activation* in cancer cells , we investigated if the combination of SMC3 and luteolin would achieve a synergistic anticancer activity . Positive_regulation RELA TNF 19751407 2135260 Inhibition of induced *activation* of [NF-kappaB] by hantavirus nucleocapsid proteins . Positive_regulation RELA TNF 19751727 2147302 We recently reported that diacylglycerol kinase (DGK) alpha enhanced induced *activation* of [nuclear factor-kappaB (NF-kappaB)] . Positive_regulation RELA TNF 19751727 2147308 These results strongly suggest that DGKalpha positively regulates dependent [NF-kappaB] *activation* via the PKCzeta mediated Ser311 phosphorylation of p65/RelA . Positive_regulation RELA TNF 19760502 2264288 Moreover , *promoted* ErbB-2/ErbB-3 heterocomplex formation , Akt activation and [NF-kappaB] transcriptional activation . Positive_regulation RELA TNF 19760502 2264291 Inhibition of ErbB-2 by addition of AG825 , an epidermal growth factor receptor/ErbB-2-tyrosine kinase inhibitor , or knockdown of ErbB-2 by RNA interference strategy , blocked induced [NF-kappaB] *activation* and proliferation . Positive_regulation RELA TNF 19763702 2175980 High fat diet increased hepatic levels of SREBP-1c , TLR4 , , and IL-6 protein and mRNA and increased *activation* of [p65NF-kappaB] . Positive_regulation RELA TNF 19765578 2153530 In addition , M1-M4 significantly suppressed *induced* [NF-kappaB] transcriptional activity . Positive_regulation RELA TNF 19765578 2153532 Treatment of HT-29 cells with M1 and PDTC , a NF-kappaB inhibitor , synergistically suppressed both induced [NF-kappaB] *activation* and monocytic cell adhesion to HT-29 cells . Positive_regulation RELA TNF 19768141 2140935 The effect of Tq on the constitutive and *induced* activation and nuclear translocation of [NF-kappaB] was examined by ELISA and immunohistochemistry . Positive_regulation RELA TNF 19768141 2140938 Tq also inhibited the constitutive and mediated *activation* of [NF-kappaB] in PDA cells and reduced the transport of NF-kappaB from the cytosol to the nucleus . Positive_regulation RELA TNF 19770515 2147454 TRAF3 siRNA prevented *induced* [NF-kappaB] p100 accumulation and inhibition of osteoclastogenesis . Positive_regulation RELA TNF 19810754 2159672 It has been assumed that TRAF2 is a ubiquitin ligase like TRAF6 and mediates K63 linked polyubiquitination of RIP1 , a kinase pivotal in *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 19814997 2184079 Heteronemin , a spongean sesterterpene , inhibits induced [NF-kappa B] *activation* through proteasome inhibition and induces apoptotic cell death . Positive_regulation RELA TNF 19827018 2209357 Moreover , baicalin inhibited the nuclear translocation of [NF-kappaB] *induced* by H/R or . Positive_regulation RELA TNF 19830703 2164835 Further , CC2 and LZ peptides attenuate RANKL- and *induced* [NF-kappaB] signaling in bone marrow derived osteoclast precursors ( OCPs ) . Positive_regulation RELA TNF 19842893 2155393 After treated with HES , these provoked perianastomotic tissue MPO activity , MDA levels , [NF-kappa B] *activation* , and plasma levels of and IL-6 were suppressed and GSH levels were restored , especially in 15 ml/kg HES group . Positive_regulation RELA TNF 19858207 2170405 We showed that kallistatin inhibits *induced* [NF-kappaB] activation , as well as vascular cell adhesion molecule-1 and monocyte chemoattractant protein-1 expression in endothelial cells , whereas knockdown of KLF4 by small interfering RNA oligonucleotide abolished the effect of kallistatin . Positive_regulation RELA TNF 1986224 152167 The *activation* of [NF-kappa B-like] activities ( called NF-kappa B ) by and the phorbol ester phorbol 12-myristate 13-acetate ( PMA ) were compared . Positive_regulation RELA TNF 1986224 152169 [NF-kappa B] activation by TNF alpha was initially cycloheximide insensitive , but maintenance of NF-kappa B activity *required* ongoing protein synthesis and continuous stimulation by . Positive_regulation RELA TNF 1986224 152173 We suggest that cell-specific differences in the protein kinase C-dependent activation of NF-kappa B may exist and that and PMA may *induce* expression of the gene ( s ) encoding [NF-kappa B] . Positive_regulation RELA TNF 19874203 2258362 We investigated the effects of EPA on differentiation of RAW264.7 monocyte/macrophage cells induced by receptor activator of NF-kappaB ligand ( RANKL ) and on *activation* of [NF-kappaB] by or exposure to modeled weightlessness . Positive_regulation RELA TNF 19874889 2184458 USP11 negatively regulates induced [NF-kappaB] *activation* by targeting on IkappaBalpha . Positive_regulation RELA TNF 19874889 2184466 Moreover , knockdown of USP11 expression enhances *induced* IkappaBalpha ubiquitination and [NF-kappaB] activation . Positive_regulation RELA TNF 19874889 2184468 These data demonstrate that USP11 plays an important role in the downregulation of mediated [NF-kappaB] *activation* through modulating IkappaBalpha stability . Positive_regulation RELA TNF 19874889 2184475 In addition , overexpression of a catalytically inactive USP11 mutant partially inhibits TNFalpha- and IKKbeta induced NF-kappaB activation , suggesting that USP11 also exerts a non-catalytic function in its negative regulation of mediated [NF-kappaB] *activation* . Positive_regulation RELA TNF 19874889 2184479 Thus , IkappaBalpha ubiquitination and deubiquitination processes function as a Yin-Yang regulatory mechanism on induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 19875812 2187919 Overexpression of C/EBPbeta markedly suppressed induced *activation* of [NF-kappaB] , independent of its transacting potential . Positive_regulation RELA TNF 19887769 2197289 Both and IL-1beta *activated* [NF-kappaB] and stimulated IL-8 production . Positive_regulation RELA TNF 19897171 2197451 Intra-abdominal sepsis led to significant decreases in colonic anastomotic bursting pressures , perianastomotic tissue HP contents , GSH levels , and plasma levels of PC , along with increases in perianastomotic tissue MPO activity , MDA levels , [NF-kappaB] *activation* , and plasma levels of , IL-6 , and d-dimer . Positive_regulation RELA TNF 19910467 2189302 Ubiquitination and deubiquitination of receptor interacting protein 1 (RIP1) play an important role in the positive and negative regulation of the induced [nuclear factor kappaB (NF-kappaB)] *activation* . Positive_regulation RELA TNF 19910467 2189305 Therefore , our results demonstrate that USP21 plays an important role in the down-regulation of induced [NF-kappaB] *activation* through deubiquitinating RIP1 . Positive_regulation RELA TNF 19927158 2203744 Furthermore , several cell types from E18 RIPK1 ( -/- ) embryos seem to activate [NF-kappaB] in *response* to . Positive_regulation RELA TNF 19934328 2172247 TRADD is a crucial transducer for induced [nuclear factor-kappaB (NF-kappaB)] *activation* . Positive_regulation RELA TNF 19934328 2172253 Knocking down TRADD expression in LNCaP cells impaired induced [NF-kappaB] *activation* and androgen receptor repression , whereas overexpression of TRADD in C4-2B cells restored their sensitivity to TNF-alpha . Positive_regulation RELA TNF 19958645 2174362 The expression and localization of NF-kappaB in HCC tissues are obviously different from those in the surrounding normal liver tissues , and the level of nucleoprotein NF-kappaB in HCC tissues is correlated with expressed TNF alpha , suggesting that can *activate* [NF-kB] , the activated NF-kB then translocates to the nucleus and plays important role in the carcinogenesis of HCC . Positive_regulation RELA TNF 19959714 2204099 FAT10 is a TNF-alpha-inducible ubiquitin-like protein with a putative role in immune response , but whether FAT10 participates in induced [NF-kappaB] *activation* is unknown . Positive_regulation RELA TNF 19959714 2204101 Here , using renal tubular epithelial cells ( RTECs ) derived from FAT10 ( -/- ) and FAT10 ( +/+ ) mice , we observed that FAT10 deficiency abrogated induced [NF-kappaB] *activation* and reduced the induction of NF-kappaB regulated genes . Positive_regulation RELA TNF 19962318 2199493 Screening of six compounds for the ability to inhibit *induced* [NF-kappaB] activity revealed that compound SK2009 was the most potent of these compounds in suppressing NF-kappaB activation in KBM-5 leukemic cells . Positive_regulation RELA TNF 19966295 2190826 Indole also decreased *mediated* activation of [NF-kappaB] , expression of the proinflammatory chemokine IL-8 , and the attachment of pathogenic E. coli to HCT-8 cells , as well as increased expression of the antiinflammatory cytokine IL-10 . Positive_regulation RELA TNF 20005846 2174906 LUBAC enhances NEMO interaction with the TNF-RSC , stabilizes this protein complex , and is required for efficient induced *activation* of [NF-kappaB] and JNK , resulting in apoptosis inhibition . Positive_regulation RELA TNF 20018848 2204632 Azadirachtin blocks *induced* activation of [nuclear factor kappaB (NF-kappaB)] and also expression of NF-kappaB dependent genes such as adhesion molecules and cyclooxygenase 2 . Positive_regulation RELA TNF 20022690 2232335 [Nuclear factor-kappa B (NF-kappaB)] *activation* by attenuates the TNF-alpha induced apoptosis pathway . Positive_regulation RELA TNF 20022690 2232337 Such sensitization is closely associated with the inhibitory effect of HA14-1 on mediated [NF-kappaB] *activation* . Positive_regulation RELA TNF 20032777 2205156 SHetA2 inhibited basal and *induced* or hydrogen peroxide induced [NF-kappaB] activity through counter-regulation of upstream kinase ( IkappaB kinase ) activity , inhibitor protein ( IkappaB-alpha ) phosphorylation , and p-65 NF-kappaB subunit nuclear translocation , but independently of reactive oxygen species generation . Positive_regulation RELA TNF 20039412 2192704 *stimulated* translocation of [NF-kappaB] into the nucleus and NF-kappaB promoter activity were blocked by Bay11-7082 , but not by U0126 , SB202190 , or SP600125 . Positive_regulation RELA TNF 20045454 2205380 The *activation* of [NF-kappaB] by was completely blocked by a Lagerstroemia speciosa extract in a dose- and time dependent manner in H9c2 cells . Positive_regulation RELA TNF 20049872 2200700 activated ERK and *increased* [NF-kappaB] promoter activity . Positive_regulation RELA TNF 20052674 2211739 *Activation* of [NF-kappaB] by enhances p50/RelA binding to the NF-kappaB binding sites . Positive_regulation RELA TNF 20054232 2211851 In addition , treatment with GFW significantly suppressed *induced* reactive oxygen species production and [NF-kappaB] transcriptional activity in HT-29 cells . Positive_regulation RELA TNF 20065354 2225506 In contrast , TRAF2 siRNA knockdown , targeting receptor mediated NF-kappaB activation , blocked but not HDACI *mediated* [NF-kappaB] activation and lethality . Positive_regulation RELA TNF 20071450 2194125 Low *induced* [NF-kappaB] and p38 phosphorylation levels in leucocytes in tumour necrosis factor receptor associated periodic syndrome . Positive_regulation RELA TNF 20071450 2194128 Because the pathomechanism of TRAPS may involve aberrant TNF mediated intracellular signalling , we examined phosphorylation levels of [nuclear factor kappaB (NF-kappaB)] and p38 in *response* to in 10 patients with three different TNFRSF1A mutations ( C73R , C88Y and F112I ) . Positive_regulation RELA TNF 20072622 2194145 Degraded carrageenan causing colitis in rats *induces* secretion and ICAM-1 upregulation in monocytes through [NF-kappaB] activation . Positive_regulation RELA TNF 20080763 2194360 increased caspase-3 activity but *activated* neither [NF-kappaB] nor JNK in Tak1-deficient hepatocytes . Positive_regulation RELA TNF 20098747 2201946 Overexpression of CALB1 , CDK2 and SAG was found to stimulate transcriptional activation by NF-kappaB , while SYT1 overexpression repressed *dependent* [NF-kappaB] transcriptional activation in human embryonic kidney cells . Positive_regulation RELA TNF 20100622 2226348 The isolated compounds were evaluated for their cancer chemopreventive potential based on their ability to inhibit *induced* [NF-kappaB] activity , nitric oxide ( NO ) production , aromatase , quinone reductase 2 (QR2) and COX-1/-2 activities . Positive_regulation RELA TNF 20100622 2226350 Palmatosides B ( 2 ) and C ( 3 ) inhibited *induced* [NF-kappaB] activity with IC ( 50 ) values of 15.7 and 24.1 microM , respectively ; Positive_regulation RELA TNF 20103840 2178628 UCB prevented the nuclear translocation of [NF-kappaB] *induced* by . Positive_regulation RELA TNF 20104512 2272247 A further analysis indicated that EGJ attenuated *induced* nuclear p65 [nuclear factor-kappa B (NF-kappaB)] translocation , suggesting that EGJ primarily affects the TNF-alpha induced NF-kappaB signaling pathway . Positive_regulation RELA TNF 20104512 2272249 Taken together , we provided here the first evidence showing that EGJ is able to inhibit *induced* [NF-kappaB] activation , adhesion molecule expression , and monocyte-endothelial interaction , suggesting an anti-inflammatory role of EGJ , which may be useful in preventing vascular diseases , such as atherosclerosis . Positive_regulation RELA TNF 20126461 2207219 In cultured tubular cells , TWEAK and *activated* different DNA binding [NFkappaB] complexes . Positive_regulation RELA TNF 20130413 2293653 stimulation *activated* [NF-kappaB] through induction of IkappaB phosphorylation , but the activation can be suppressed by TSA . Positive_regulation RELA TNF 20135642 2235893 *mediated* an increase of [NF-kappaB-specific] DNA-protein complex formation , p65 translocation into nucleus , NF-kappaB-luciferase activity was inhibited by KP392 , Akt inhibitor , and rapamycin . Positive_regulation RELA TNF 20138025 2227040 We found that bisdemethylcurcumin ( BDC ) was more potent than curcumin as an anti-inflammatory agent as indicated by suppression of induced [NF-kappaB] *activation* , more potent as an anti-proliferative agent , and more potent in inducing ROS . Positive_regulation RELA TNF 20138622 2280973 N-acetylcysteine , SP600125 ( JNK inhibitor ) and SB203580 ( p38 MAPK inhibitor ) attenuated *induced* DNA binding activities of both AP-1 and [NF-kappaB] . Positive_regulation RELA TNF 20147406 2227469 Expression of ORFV024 in cell cultures significantly decreased lipopolysaccharide (LPS)- and *induced* [NF-kappaB-responsive] reporter gene expression . Positive_regulation RELA TNF 20147406 2227473 Further , ORFV024 expression decreased *induced* phosphorylation and nuclear translocation of [NF-kappaB-p65] , phosphorylation , and degradation of IkappaBalpha , and phosphorylation of IkappaB kinase (IKK) subunits IKKalpha and IKKbeta , indicating that ORFV024 functions by inhibiting activation of IKKs , the bottleneck for most NF-kappaB activating stimuli . Positive_regulation RELA TNF 20153843 2236122 Previously , we reported that a major component , Licochalcone A , potently inhibited induced [NF-kappaB] *activation* by inhibiting IKKbeta activation . Positive_regulation RELA TNF 20153843 2236125 Interestingly , reduced Licochalcone A , which lacks a double bond , failed to inhibit induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 20168983 2180747 We also demonstrate that Rottlerin prevents *dependent* [NFkappaB] activation in MCF-7 cells and in HT-29 cells transfected with the NFkappaB-driven plasmid pBIIX-LUC , suggesting that Rottlerin can inhibit NFkappaB via several pathways and in several cell types . Positive_regulation RELA TNF 20185819 2236862 In contrast , *activation* of [NFkappaB] by did not depend on TRAF3 levels . Positive_regulation RELA TNF 20195534 2216371 Analysis of [NF-kappaB] activation in *response* to in MEFs reveals that IKKbeta is essential for efficient phosphorylation and subsequent degradation of IkappaB alpha , yet IKKalpha contributes to the NF-kappaB activation response in these cells as measured via DNA binding assays . Positive_regulation RELA TNF 20196785 2180968 In addition , treatments involving E ( 2 ) , membrane-impermeable BSA-E ( 2 ) and/or Dox , which induces ERalpha overexpression , significantly inhibited LPS induced apoptosis by suppressing LPS-up regulated JNK1/2 activity , IkappaB degradation , [NFkappaB] *activation* and pro-apoptotic proteins ( e.g . , active caspases-8 , t-Bid , Bax , released cytochrome c , active caspase-9 , active caspase-3 ) in myocardial cells . Positive_regulation RELA TNF 20200474 2265332 It has been shown that NQO1 is also essential for the TNF induced activation of NF-kappaB and that beta-lap suppresses the *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 20205746 2229740 significantly *induced* phosphorylation of [NFkappaB] at Ser 536 and Ser 468 , but not at Ser 529 or Ser 276 . Positive_regulation RELA TNF 20205746 2229774 These results strongly suggest that *induces* IL-6 synthesis through the JAK/STAT3 pathway in addition to p38 MAP kinase and SAPK/JNK in C6 glioma cells , and that phosphorylation of [NFkappaB] at Ser 536 and Ser 468 , and NADPH oxidase are involved in TNF-alpha stimulated IL-6 synthesis . Positive_regulation RELA TNF 20220144 2249442 As IL-17 stimulation stabilizes the IkappaB-zeta transcript , we propose a model where *induces* activation and binding of [NF-kappaB] to the promoters of both NFKBIZ and LCN2 genes but induce only transcription of IkappaB-zeta . Positive_regulation RELA TNF 20226764 2237552 In addition , IRS-3 augmented the binding activity of p50 to the NF-kappaB DNA binding site , as well as the *induced* transcriptional activity of [NF-kappaB] . Positive_regulation RELA TNF 20231278 2254521 Maml1-deficient mouse embryonic fibroblasts showed impaired *induced* [NF-kappaB] responses . Positive_regulation RELA TNF 20231449 2230275 Activities tested included inhibition of : HCV cell culture infection , NS5B polymerase activity , *induced* [NF-kappaB] transcription , virus induced oxidative stress , and T-cell proliferation . Positive_regulation RELA TNF 20237236 2259894 *caused* activation of [NF-kappaB] , MAP kinases , and PI3K-Akt in podocytes , whereas blockade of these molecules did not affect inhibition of RAR by TNF-alpha . Positive_regulation RELA TNF 20300512 2230414 When challenged with either intratracheal zymosan or LPS , NADPH oxidase-deficient p47 ( phox-/- ) mice and gp91(phox)-deficient mice developed exaggerated and progressive lung inflammation , augmented [NF-kappaB] *activation* , and elevated downstream pro-inflammatory cytokines ( , IL-17 , and G-CSF ) compared to wildtype mice . Positive_regulation RELA TNF 20337659 2287566 1. The novel nuclear factor (NF)-kappaB inhibitor dehydroxymethylepoxyquinomicin ( DHMEQ ) is a derivative of the antibiotic epoxyquinomicin C from Amycolatopsis sp. that has been found to inhibit *induced* activation of [NF-kappaB] by suppressing nuclear translocation of NF-kappaB . Positive_regulation RELA TNF 20350779 2281937 In contrast , [NF-kappaB] *activation* by or expression of constitutively active IKK2 induced an EMT-phenotype with up-regulation of vimentin and ZEB1 , and down-regulation of E-cadherin . Positive_regulation RELA TNF 20353839 2273289 *Activation* of [NF-kappaB] by fluid shear stress , but not , requires focal adhesion kinase in osteoblasts . Positive_regulation RELA TNF 20353839 2273291 We examined the role of a key component of focal adhesions and of mechanotransduction , focal adhesion kinase ( FAK ) in regulation of FSS- and induced *activation* of [nuclear factor-kappa B (NF-kappaB)] signaling in osteoblasts . Positive_regulation RELA TNF 20356846 2266543 The RING functions of cIAP1 are required for full induced *activation* of [NF-kappaB] , however , delayed activation of NF-kappaB still occurs in cIAP1 and -2 double knock-out cells . Positive_regulation RELA TNF 20363280 2261072 Further studies revealed that EC extracts suppress the production of and *activation* of [nuclear factor-kappa B (NF-kappaB)] . Positive_regulation RELA TNF 20367887 2245059 In this study , we demonstrate that MA significantly enhanced TNFalpha induced inhibition of pancreatic cancer cell proliferation , invasion , and potentiated TNFalpha induced cell apoptosis by suppressing *induced* [NF-kappaB] activation in a dose- and time dependent manner . Positive_regulation RELA TNF 20368026 2238482 these results indicate that E1A protein upregulated [NF-kappaB] transcription activity *induced* by LPS and in rat alveolar epithelial cells and this effect could be repressed by NAC . Positive_regulation RELA TNF 20370892 2273380 In vitro , HpTNFR1 reduced the TNFR1 mRNA expression by three-fold resulting in a 70 % reduction of induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 20372995 2261765 however , was unable to *induce* [NF-kappaB] in post-intervention samples , suggesting that the mixture of four important natural agents could be useful to protect humans against oxidative stress . Positive_regulation RELA TNF 20378831 2273552 *induced* [NF-kappaB] activation was blocked and IkappaBalpha expression was higher in HCT116 cells lacking DNMT than in parental cells . Positive_regulation RELA TNF 20385167 2267204 Also , 1alpha,25 ( OH ) ( 2 ) D ( 3 ) did not suppress the *activation* of [NF-kappaB] by or PHA . Positive_regulation RELA TNF 20385564 2267212 To study the involvement of NF-kappaB in G ( 1 ) /S phase regulation , the levels of selected transcriptional regulators were monitored following overexpression of [NF-kappaB] or its physiological *induction* by . Positive_regulation RELA TNF 20404154 2255863 Chromatin immunoprecipitation assays further indicate that estrogen suppresses *induced* [NFkappaB] recruitment to the CCL2 enhancer . Positive_regulation RELA TNF 20410444 2307414 Characterization of the human biliverdin reductase gene structure and regulatory elements : promoter activity is enhanced by hypoxia and suppressed by *activated* [NF-kappaB] . Positive_regulation RELA TNF 20440096 2282729 *activated* the [NF-kappaB] and the JNK pathways . Positive_regulation RELA TNF 20448200 2262758 In particular , vinpocetine inhibits induced [NF-kappaB] *activation* and the subsequent induction of proinflammatory mediators in multiple cell types , including vascular smooth muscle cells , endothelial cells , macrophages , and epithelial cells . Positive_regulation RELA TNF 20462248 2283152 14-3-3 epsilon dynamically interacts with key components of mitogen activated protein kinase signal module for selective modulation of the *induced* time course dependent [NF-kappaB] activity . Positive_regulation RELA TNF 20462248 2283156 We then postulated a mechanistic view describing how 14-3-3 epsilon coordinates its dynamic interactions with TAK1 and PPM1B for differentially modulating *induced* changes in [NF-kappaB] activity . Positive_regulation RELA TNF 20472834 2301098 IFNgamma and *activate* [NF-kappaB] that in turn induces B7-H1 expression on MDS blasts . Positive_regulation RELA TNF 20478530 2263056 TAK1 mediated cancer suppression is exerted through activating [NF-kappaB] in *response* to and through preventing Caspase-3 dependent hepatocyte and cholangiocyte apoptosis . Positive_regulation RELA TNF 20481500 2276149 Fijiolides A and B , inhibitors of induced [NFkappaB] *activation* , from a marine derived sediment bacterium of the genus Nocardiopsis . Positive_regulation RELA TNF 20481500 2276151 Fijiolide A , a potent inhibitor of *induced* [NFkappaB] activation , along with fijiolide B , were isolated from a marine derived bacterium of the genus Nocardiopsis . Positive_regulation RELA TNF 20481500 2276153 Fijiolide A reduced induced [NFkappaB] *activation* by 70.3 % , with an IC ( 50 ) value of 0.57 micro-M . Positive_regulation RELA TNF 20482259 2294618 We have established a standardized method for preparing aqueous extracts ( teas ) from the selected medicinal herbs and screened for inhibition of induced *activation* of [nuclear factor kappaB (NF-kappaB)] , which is the central signaling pathway of the inflammatory response . Positive_regulation RELA TNF 20482842 2276193 Further , inactivation of Bcr-Abl by imatinib pretreatment did not abrogate the *induced* [NF-kappaB] activation while silencing p65 by siRNA did not affect the levels of Bcr-Abl , both results together indicating that NF-kappaB inactivation and Bcr-Abl inhibition may be parallel independent pathways . Positive_regulation RELA TNF 20484576 2288697 PLK1 inhibits [NF-kappaB] transcriptional activation *induced* by , IL-1beta , or several activators , but not by nuclear transcription factor p65 . Positive_regulation RELA TNF 20484576 2288703 PLK1 expression reduces the DNA binding activity of [NF-kappaB] *induced* by . Positive_regulation RELA TNF 20484867 2276260 NAC inhibited *induced* phosphorylation of JNK and p38 but not [NF-kappaB] . Positive_regulation RELA TNF 20499049 2276493 The results obtained from this study revealed that CTB glycoprotein ( 100 microg/ml ) inhibits the translocation of PKC from cytosol to the membrane , the phosphorylation of p38 MAPK , the *activation* of [NF-kappaB] , and the expression levels of and IL-6 . Positive_regulation RELA TNF 20511226 2289466 We previously reported that methyl-beta-cyclodextrin eliminates caveolae and blocks tumor necrosis factor (TNF) induced internalization of TNFR1 but not *induced* activation of [NF-kappaB] in EA.hy926 cells . Positive_regulation RELA TNF 20511226 2289470 Both knockdowns reduce total TNFR1 protein expression , but neither prevents TNFR1 localization to low density membrane domains , induced internalization of TNFR1 , or [NF-kappaB] *activation* by TNF . Positive_regulation RELA TNF 20514534 2289508 These results link the gliadin derived peptides induced production through cAMP dependent PKA activation , where ion channels controlling calcium influx into cells could play a protective role , and *requires* [NF-kappaB] activation . Positive_regulation RELA TNF 20519138 2289583 In addition , icariin suppressed the secretion of , prostaglandin E2 ( PGE ( 2 ) ) and nitric oxide ( NO ) as well as [NF-kappaB] p65 *activation* . Positive_regulation RELA TNF 20523058 2271283 In this mechanism , may *activate* [NF-kappaB] , in cooperation with TLR3 signaling . Positive_regulation RELA TNF 20529958 2289645 In contrast , *activation* of [NF-kappaB] by was not affected . Positive_regulation RELA TNF 20538607 2301914 Results of Sp1 , Sp3 , and Sp4 knockdown by RNA interference demonstrate that both p50 and p65 are Sp-regulated genes and that inhibition of constitutive or *induced* [NFkappaB] by curcumin is dependent on down-regulation of Sp1 , Sp3 , and Sp4 proteins by this compound . Positive_regulation RELA TNF 20540783 2284778 Commensal depletion decreased TLR4 expression as well as [NF-kappaB] *activation* of intestine , myeloperoxidase (MPO) activity as well as expression of lung , and bacterial killing activity of peritoneal cells . Positive_regulation RELA TNF 20555427 2279748 In addition , PGE1 suppressed *induced* [NF-kappaB] activation and production of reactive oxygen species . Positive_regulation RELA TNF 20558233 2302441 To elucidate the molecular mechanism of inhibition of cell adhesion molecules , we investigated the status of nuclear transcription factor-kappaB ( NF-kappaB ) and were able to establish that beta-sitosterol significantly blocked the induced *activation* of [NF-kappaB] . Positive_regulation RELA TNF 20562516 2290160 NAC also inhibited *induced* phosphorylation of Akt and [NF-kappaB] . Positive_regulation RELA TNF 20562516 2290167 W-7 and KN93 inhibited *induced* phosphorylation of Akt but not [NF-kappaB] . Positive_regulation RELA TNF 20566746 2296079 In ccRCC organ cultures , increases TNFR1 , *activates* apoptotic signaling kinase and [NF-kappaB] , and promotes apoptosis in malignant TECs . Positive_regulation RELA TNF 20571239 2280270 We further examined the molecular mechanisms and found that the combination of Sal B and LSS treatment dramatically inhibited induced [NF-kappaB] *activation* evidenced by IkappaBalpha degradation and p65 nuclear translocation in HAECs . Positive_regulation RELA TNF 20576605 2303179 it inhibited [NF-kappaB] activation *induced* by , phorbol 12-myristate 13-acetate , lipopolysaccharide , and cigarette smoke . Positive_regulation RELA TNF 20581820 2285563 We developed a stochastic mathematical model that reproduces both the digital and analogue dynamics as well as most gene expression profiles at all measured conditions , constituting a broadly applicable model for *induced* [NF-kappaB] signalling in various types of cells . Positive_regulation RELA TNF 20593161 2309246 We therefore examined the effect of liraglutide on induced [NF-kappaB] *activation* and NF-kappaB dependent expression of proinflammatory genes . Positive_regulation RELA TNF 20599780 2303589 Using the electrophoretic mobility shift assay , we found that CDC was more active than free curcumin in inhibiting induced *activation* of the inflammatory transcription factor [NF-kappaB] and in suppressing gene products regulated by NF-kappaB , including those involved in cell proliferation ( cyclin D1 ) , invasion ( MMP-9 ) , and angiogenesis ( VEGF ) . Positive_regulation RELA TNF 20599928 2290856 These data suggest that CAPE inhibits dependent [NFkappaB] *activation* via direct inhibition of IKK as well as activation of Nrf2 pathway , in which the functional groups in CAPE may be involved . Positive_regulation RELA TNF 20600852 2303726 In this study , we show that KEAP1 is a new IKK binding partner , which is responsible for the down-regulation of *stimulated* [NF-kappaB] activation . Positive_regulation RELA TNF 2065663 162458 NAC and other thiol compounds also blocked the *activation* of [NF-kappa B] by cycloheximide , double stranded RNA , calcium ionophore , , active phorbol ester , interleukin-1 , lipopolysaccharide and lectin . Positive_regulation RELA TNF 20691659 2311992 Using a knockdown approach in Ewing sarcoma cells , we demonstrated that EWS-FLI1 has no influence on NFkappaB basal activity , but impairs *induced* [NFkappaB-driven] transcription , at least in part through inhibition of NFkappaB binding to DNA . Positive_regulation RELA TNF 20700770 2312401 25HC also decreased cytoplasmic IkappaBalpha levels and further increased induced [NFkappaB] *activation* . Positive_regulation RELA TNF 20704259 2312786 TNF receptor ubiquitous scaffolding and signaling protein (TRUSS) , a 90.1 kDa TNF-R1 associated scaffolding protein , also interacts with TRAF2 and IKK and contributes to *induced* [nuclear factor-kappaB (NF-kappaB)] and c-Jun-NH ( 2 ) -terminal kinase ( JNK ) activation . Positive_regulation RELA TNF 20724660 2317995 Virus induced IRF3 and NF-kappaB activation , as well as K27 linked NEMO polyubiquitination , were abrogated in TRIM23 knockdown cells , whereas TRIM23 knockdown had no effect on mediated [NF-kappaB] *activation* . Positive_regulation RELA TNF 20729202 2335714 Synergistic *activation* of [NF-{kappa}B] by bacterial chemoattractant and } is mediated by p38 MAPK dependent RelA acetylation . Positive_regulation RELA TNF 20839630 2319104 All compounds derived from black pepper suppressed *induced* [NF-kappaB] activation , but alkyl amides , compound 4 from black pepper and 5 from hot pepper , were most effective . Positive_regulation RELA TNF 20953353 2333451 While only *activates* canonical [NF-kappaB] signaling , TWEAK promotes both canonical and noncanonical NF-kappaB activation in tubular cells , regulating different inflammatory responses . Positive_regulation RELA TNF 21109521 2383539 Changes in expression of membrane , [NF-{kappa}B] *activation* and neutrophil apoptosis during active and resolved inflammation . Positive_regulation RELA TNF 2115119 137392 Comparison of the *induced* factor and lipopolysaccharide induced [NF-kappa B] in gel mobility shift assays upon partial protease digestion suggests similar DNA binding protein cores . Positive_regulation RELA TNF 21196314 2373980 In the TGase 2-inducible EcR23/TG cell line , TGase 2 over-expression resulted in sustained activation of [NF-kappa B] in the *presence* of , for up to 24 hrs , while in the absence of TGase 2 induction , NF-kappaB activity was restored to basal levels within 6 hrs of TNF-alpha treatment . Positive_regulation RELA TNF 21196321 2373983 DNA binding assays revealed that combination treatment suppressed both basal and induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 21208380 2396957 TNFAIP3 encodes the ubiquitin modifying enzyme , also known as A20 , which is a cytoplasmic zinc finger protein that inhibits [nuclear factor kappa-B (NFKB)] activity and *mediated* programmed cell death . Positive_regulation RELA TNF 21283748 2387869 Here we report that human monocytes treated with SEA , SEB , or anti-MHC class II monoclonal antibodies up regulated MyD88 expression , induced *activation* of [NF-kB] , and increased expression of IL-1R1 accessory protein , and IL-1ß . Positive_regulation RELA TNF 21343177 2431549 Thymosin beta4 inhibits *induced* [NF-kappaB] activation , IL-8 expression , and the sensitizing effects by its partners PINCH-1 and ILK . Positive_regulation RELA TNF 21344491 2415384 Consistently , treatment of HeLa cells with the compound significantly suppressed *induced* activation of Akt and phosphorylation of Ser536 in [RelA/p65] , which is required for transactivation activity . Positive_regulation RELA TNF 21375727 2404367 While the extract stimulated PPAR? dependent luciferase activity and activated AMPK in C2C12 cells , it inhibited *stimulated* [IKKß/NFkB] signaling and attenuated ER stress in HepG2 cells . Positive_regulation RELA TNF 2146676 144084 Our finding that *induction* of [NF-kappa B] by or antibody to CD3 is not sufficient to induce HIV enhancer dependent transcription in cloned T cells contrasts with results obtained in most lymphoblastoid T-cell lines and indicates that normal T lymphocytes differ from tumoral T cells in terms of requirements for HIV LTR activation . Positive_regulation RELA TNF 21528184 479057 For NF-kappa B , this was in apparent contradiction with its reported inducibility mediated by LMP1 , taking into account that [NF-kappa B] was still *inducible* by or PMA and ionomycin . Positive_regulation RELA TNF 21541574 407736 These results are in contrast to those reported for the murine p53 gene , whose promoter is *induced* by through activation of the [NF-kappa B] transcription factor . Positive_regulation RELA TNF 21598036 2480892 Therefore , these findings suggest that clasmatodendrosis may be autophagic astroglial death in response to epileptic seizures through *mediated* [p65/RelA-Ser529] phosphorylation . Positive_regulation RELA TNF 21601601 2464268 TAK1 mediated cancer suppression is exerted through activating [NF-kappaB] in *response* to and through preventing Caspase-3 dependent hepatocyte and cholangiocyte apoptosis . Positive_regulation RELA TNF 2176217 146959 Both the types A and B receptors mediated induced *activation* of the transcription factor [NF-kappa B] . Positive_regulation RELA TNF 21826987 2463245 [ Effect of heat shock protein 90 inhibitor 17-dimethylamino-ethylaminogeldanamycin on TNfalpha mediated apoptosis and induced [NF-kappaB] *activation* ] . Positive_regulation RELA TNF 21826987 2463274 17DMAG sensitized cervical cancer cells HeLa and ovarian cancer cells SKOV3 to TNFalpha induced cell death in a dose dependent manner , which was accompanied with degradation of RIP and Ikappakappabeta , and consequent blockage of induced [NFkappaB] *activation* . Positive_regulation RELA TNF 21826987 2463276 17DMAG sensitizes cancer cells to TNFalpha mediated apoptosis through blockage of induced [NF-kappaB] *activation* , and disabling this survival signal with 17DMAG followed by TNF treatment could be an effective new therapeutic strategy for improving the anti-cancer value of TNFalpha . Positive_regulation RELA TNF 22038897 2513762 We found that CAPE did not inhibit *induced* I?B phosphorylation/degradation or nuclear translocation of [RelA/p65] , but targeted downstream signaling events at the level of transcription factor recruitment to the gene promoter . Positive_regulation RELA TNF 22334708 2580730 Knockdown analysis using 293FT reporter cells that endogenously express these five proteins at low levels clearly showed that DPF3a and DPF3b , which are produced from the DPF3 gene by alternative splicing , are the most critical for the [RelA/p50] NF-?B heterodimer transactivation *induced* by stimulation . Positive_regulation RELA TNF 22339724 2560754 Results indicate that these Hb solutions have different effects on stabilization and nuclear translocation of hypoxia-inducible factor (HIF)-1 alpha , induction of the erythropoietin (EPO) gene , *activation* of [nuclear factor (NF)-kappa B] , and expression of the anti-erythropoietic and transforming growth factor-beta 1 . Positive_regulation RELA TNF 2279003 147440 Additionally , our data show that both dsRNA and LPS , as well as itself , rapidly *induce* [nuclear factor-kappa B (NF-kappa B)] , a DNA binding protein implicated in regulation of gene expression . Positive_regulation RELA TNF 22895565 2713532 Interestingly , reduction of MMS22L by siRNAs in cancer cells inhibited the *dependent* activation of [RelA/p65] in the NFKB pathway and expression of its downstream anti-apoptotic molecules such as Bcl-XL and TRAF1 . Positive_regulation RELA TNF 22911724 2648576 BME also attenuated *induced* activation of [NFkappaB] in differentiating preadipocytes and partially restored TNFalpha mediated suppression on adipogenesis . Positive_regulation RELA TNF 22911724 2648581 Using a non-adipogenic HEK293 cell line transfected with luciferase reporter genes , we demonstrated that BME reduced basal and *induced* [NFkappaB] activity and increased basal and ciglitazone induced PPARgamma activity ; Positive_regulation RELA TNF 23174100 2700543 Our results showed that TNF-alpha treatment increased Bcl-2 mRNA and protein levels in breast cancer cells , suggesting that Bcl-2 is directly regulated by [nuclear factor-kappaB (NF-kappaB)] in *response* to . Positive_regulation RELA TNF 23174100 2700550 Silencing of sClu in MDA-MB-231/sClu siRNA cells abrogated mediated [NF-kappaB] *activation* and Bcl-2 overexpression , and rendered the MDA-MB-231/sClu siRNA cells significantly more sensitive to TNF-alpha mediated apoptosis than the parental cells . Positive_regulation RELA TNF 23527709 2762040 Therefore , CD1d associated abnormalities of innate immune responses and production in splenic tissue may *contribute* to [NFkB] activation and cardiac dysfunction in type 2 diabetes . Positive_regulation RELA TNF 23734186 2796959 This increased secretion of and IL-6 and *activation* of [NF-kB] , ERK , and JNK was significantly inhibited by the addition of either mannan or mannose . Positive_regulation RELA TNF 24020126 2837288 In this study , we first examined the effect of resveratrol on endogenous and induced [NF-kappaB] *activation* , and found that resveratrol suppressed NF-kappaB activation in a dose dependent manner . Positive_regulation RELA TNF 24039253 2862638 Interestingly , LIMK1 or SSH-1L depletion failed to inhibit *induced* [RelA/p65] nuclear translocation and proinflammatory gene expression . Positive_regulation RELA TNF 24239949 2897730 TAX1BP1 recruits A20 to the ubiquitinated signaling proteins TRAF6 and RIP1 , leading to their A20 mediated deubiquitination and the disruption of IL-1 induced and *induced* [NF-kappaB] signaling , respectively . Positive_regulation RELA TNF 25204148 2958123 In the investigations of cell based in vitro assays of extracts , we found that both ethyl acetate extract and methanol extract of Lycii Cortex inhibited the *induced* activation of [NF-kappaB] . Positive_regulation RELA TNF 25204148 2958125 Four phenolic amides showed differently inhibitory activities on *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 2809216 121403 In this report , we show that *activates* [NF-kappa B] and the human immunodeficiency virus enhancer in the Jurkat T leukemia but does not stimulate the IL-2R alpha enhancer . Positive_regulation RELA TNF 7488149 332121 Cu2+ was found to inhibit the activation of [NF kappa B] *induced* by , TPA , or H2O2 . Positive_regulation RELA TNF 7523113 272178 Whereas transcription factor [NF-kappa B] was readily *activated* by , activation was not induced by triggering APO-1/Fas . Positive_regulation RELA TNF 7532017 286145 Only , LT , and IL-1 *activated* [NF-kappa B] . Positive_regulation RELA TNF 7532017 286148 Since interferons have been shown to induce TNF receptors and potentiate TNF mediated cellular responses , we also measured the effect of interferons on induced *activation* of [NF-kappa B] . Positive_regulation RELA TNF 7532017 286150 Under our conditions , all three IFNs potentiated the cytotoxic effects of TNF but had no effect on the dependent [NF-kappa B] *activation* . Positive_regulation RELA TNF 7534663 296996 Gel-shift analyses demonstrated dose dependent inhibition of *induced* [NF-kappa B] mobilization by aspirin at concentrations ranging from 1 to 10 mmol/L. Induction of VCAM-1 and E-selectin surface expression by TNF was dose-dependently reduced by aspirin over the same range , while induction of intercellular adhesion molecule-1 ( ICAM-1 ) was hardly affected . Positive_regulation RELA TNF 7540278 307217 Interestingly , exposure of MCF-Fas cells to anti-Fas or TNF induced activation of phospholipase A2 (PLA2) , while only *activated* [NF-kappa B] . Positive_regulation RELA TNF 7541425 310492 Gelshift analysis demonstrated inhibition of *induced* [nuclear factor-kappa B (NF-kappa B)] mobilization by HMA . Positive_regulation RELA TNF 7541425 310500 Our data suggest that specific phosphorylation following protein tyrosine kinase activation may be required for [NF-kappa B] mobilization and *induction* of VCAM-1 and ELAM-1 by . Positive_regulation RELA TNF 7543732 314376 Although apigenin did not inhibit *induced* nuclear translocation of [NF-kappa B] ( p50 ( NFKB1 ) /p65 ( RelA ) ) we found this flavonoid did inhibit TNF-alpha induced beta-galactosidase activity in SW480 cells stably transfected with a beta-galactosidase reporter construct driven by four NF-kappa B elements , suggesting an action on NF-kappa B transcriptional activation . Positive_regulation RELA TNF 7544915 318441 TRAF2 mediated *activation* of [NF-kappa B] by receptor 2 and CD40 . Positive_regulation RELA TNF 7559390 328009 activates the stress activated protein kinases ( SAPKs , also known as Jun nuclear kinases or JNKs ) resulting in the stimulation of AP-1 dependent gene transcription and *induces* the translocation of [NF kappa B] to the nucleus resulting in the stimulation of NF kappa B-dependent gene transcription . Positive_regulation RELA TNF 7559390 328011 also potently *stimulates* [NF-kappa B] DNA binding activity and transcriptional activity , but these effects are not mimicked by addition of C2-ceramide or sphingomyelinase to intact cells . Positive_regulation RELA TNF 7569975 328870 Stimulation by *causes* the release of [NF-kappa B] from I kappa B alpha . Positive_regulation RELA TNF 7585518 329776 ET-18-OCH3 did not inhibit [NF-kappa B] *activation* by either or IL-1 alpha , indicating that there are multiple distinct signal transduction pathways leading to activation of NF-kappa B . Positive_regulation RELA TNF 7589098 334009 IL-4 was also found partially to inhibit [NF kappa B] activity *induced* by and interleukin-1-beta (IL-1 beta) . Positive_regulation RELA TNF 7594489 334762 The effect of LPS and is mediated by their ability to *induce* nuclear translocation of the DNA binding heterodimer [NF-kappa B] ( p50/p65 ) , which binds to a specific sequence in the HIV-long terminal repeat . Positive_regulation RELA TNF 7622526 315883 Electrophoretic mobility shift assays demonstrated that *activation* of [NF-kappa B] by L-NMA , ox-LDL , and was attenuated by GSNO and SNP , but not by glutathione or cGMP analogues . Positive_regulation RELA TNF 7636259 317444 Our studies indicate that MV , , or PIPC *induces* [NF-kappa B] ( p50 and p65 subunits ) binding to positive regulatory domain II in the glioma cell line . Positive_regulation RELA TNF 7642536 317968 Here we examine the inductions of [NF-kappa B] in serum deprived and cycling cells in *response* to . Positive_regulation RELA TNF 7642536 317972 These data reveal that [NF-kappa B] is rapidly *induced* by in both proliferating and arrested cells and suggest that distinct activation pathways can lead to cell cycle dependent or -independent induction of NF-kappa B . Positive_regulation RELA TNF 7642544 317975 Inhibitors of phosphotyrosyl protein phosphatases , pervanadate and phenylarsine oxide , abrogate *induced* [nuclear factor kappa B (NF-kappa B)] nuclear translocation in transformed cell lines ( U-937 and Jurkat ) and primary fibroblasts ( MRC-5 and REF ) . Positive_regulation RELA TNF 7642544 317978 Treatment of cells with pervanadate inhibited TNF induced I kappa B-alpha phosphorylation and degradation , whereas the serine protease inhibitors tosylphenylalanyl chloromethyl ketone and N alpha-p-tosyl-L-lysine chloromethyl ketone prevented *induced* I kappa B-alpha degradation and [NF-kappa B] nuclear translocation , but not the TNF induced phosphorylation of I kappa B-alpha . Positive_regulation RELA TNF 7642556 317985 The results indicate that H2O2 activates ICAM-1 transcription through AP-1/Ets elements within the ICAM-1 promoter , which are distinct from [NF-kappa B-mediated] ICAM-1 expression *induced* by . Positive_regulation RELA TNF 7704934 288463 TNF alpha induced sphingomyelin hydrolysis , PLC mediated PC hydrolysis , and DG kinase mediated PA formation or induced [NF-kappa B] *activation* and apoptosis are not inhibited by LSF . Positive_regulation RELA TNF 7706285 297699 As the TNF gene has an NF kappa B binding motif , an autocrine loop involving *induction* of [NF kappa B] is therefore likely in these cells . Positive_regulation RELA TNF 7737374 305532 *induced* the activation of a nuclear transcriptional factor , [NF-kappa B] , equally in both young and senescent cells , which indicates the lack of a defect in the early events of TNF signal transduction in senescent fibroblasts . Positive_regulation RELA TNF 7758105 307585 Overexpression of TRADD leads to two major induced responses , apoptosis and *activation* of [NF-kappa B] . Positive_regulation RELA TNF 7758105 307588 However , NF-kappa B activation by TRADD is not inhibited by crmA expression , demonstrating that the signaling pathways for induced cell death and [NF-kappa B] *activation* are distinct . Positive_regulation RELA TNF 7759567 307808 *induced* [NF kappa B] was also inhibited by tepoxalin in HeLa cells , while relatively less marked inhibition was observed in Jurkat cells . Positive_regulation RELA TNF 7841193 293990 Similarly , N-acetylcysteine only proved inhibitory in hydrogen peroxide and TNF treated Jurkat and failed to inhibit IL1 and *activated* [NF kappa B] in EL4 . NOB-1 and KB cells respectively . Positive_regulation RELA TNF 7852340 294441 *dependent* activation of a [RelA] homodimer in astrocytes . Positive_regulation RELA TNF 7859743 295225 HIV-1 Tat potentiates induced [NF-kappa B] *activation* and cytotoxicity by altering the cellular redox state . Positive_regulation RELA TNF 7859743 295227 mediated *activation* of [NF-kappa B] and cytotoxicity involves the intracellular formation of reactive oxygen intermediates . Positive_regulation RELA TNF 7917514 269828 Secretion of IL-2 and TNF-alpha , surface expression of IL-2R , and DNA binding activity of [NF-kappa B] and AP-1 ( Fos/Jun ) complex in *response* to phorbol myristate acetate , , or immobilized antibodies to CD3 were monitored . Positive_regulation RELA TNF 7929233 274332 The post-receptor binding events that culminate in *dependent* [NF-kappa B] activation are not understood . Positive_regulation RELA TNF 7929233 274334 Overall , our results indicate that intermediates required for [NF-kappa B] *activation* by or ceramide are membrane bound , but the mechanism of activation by TNF is most likely different from that of ceramide . Positive_regulation RELA TNF 7957109 278010 Micromolar amounts of the peptide Cbz-Ile-Glu ( O-t-Bu ) -Ala-leucinal ( PSI ) , a specific inhibitor of the chymotrypsin-like activity of the proteasome , prevented activation of [NF-kappa B] in *response* to and okadaic acid ( OA ) through inhibition of I kappa B-alpha degradation . Positive_regulation RELA TNF 7964161 279447 Activation of both acid and neutral sphingomyelinases ( SMases ) has been suggested , and Schutz et al. proposed that the phosphatidylcholine-phospholipase C/acid SMase pathway is involved in *induced* [NF-kappa B] activation . Positive_regulation RELA TNF 7964161 279454 However , our recent study showed that the [NF-kappa B] activation is *induced* by in fibroblasts from patients with type A Niemann-Pick disease , with acid SMase deficiency . Positive_regulation RELA TNF 7964161 279462 This finding implies that acid SMase activity is not essential for the *activation* of [NF-kappa B] by at least in fibroblasts . Positive_regulation RELA TNF 7981153 281393 Furthermore , activation of [NFkB] was also induced in NPD type A fibroblasts in *response* to IL-1 alpha and stimulation to a similar extent as in normal fibroblasts . Positive_regulation RELA TNF 7982975 281862 Although J774 cells responded to exogenously added rTNF-alpha , but not to H2O2 , by activation of NF-kappa B , the recombinant mediated [NF-kappa B] *activation* was enhanced by simultaneous presence of H2O2 . Positive_regulation RELA TNF 7989309 282746 These results , overall , suggest that although receptors are *essential* for induction of [NF-kappa B] , a small percentage is sufficient to fully transduce this signal . Positive_regulation RELA TNF 8019435 262796 Both nitecapone and OR-1246 ( 10-300 microM ) inhibited [NF-kappa B] activation *induced* by in Jurkat T ( acute human leukemia ) cells . Positive_regulation RELA TNF 8022202 263103 In haemopoietic cell lines , *induction* of [NF-kappa B] is mediated via the generation of reactive oxygen intermediates and by the activation of protein kinase C ( PKC ) . Positive_regulation RELA TNF 8022202 263105 Raising glutathione levels with N-acetyl cysteine substantially reduced [NF-kappa B] *induction* by in two of four samples tested . Positive_regulation RELA TNF 8022202 263107 However , the protein kinase inhibitor staurosporine inhibited *induction* of [NF-kappa B] in four of five samples , suggesting that staurosporine-sensitive protein kinases ( other than PKC ) are involved in the signalling pathway . Positive_regulation RELA TNF 8022202 263109 Our results suggest that PKC independent pathways , including pathways sensitive to redox reagents , mediate the *induction* of [NF-kappa B] by in chronic B-leukaemia cells . Positive_regulation RELA TNF 8043432 266856 The *induction* of [NF kappa B] by is mediated via a novel signalling pathway involving the generation of reactive oxidative intermediates . Positive_regulation RELA TNF 8043432 266860 Here we have used an electrophoretic mobility shift assay to show that *induced* [NF kappa B] in malignant cells isolated from 3/3 HCL and 15/15 B-CLL patients . Positive_regulation RELA TNF 8046241 267021 Unlike TNF-alpha mediated cytotoxicity , the *induced* activation of [NF-kappa B] was inhibited by antioxidants regardless whether adenosine and homocysteine were present or absent in the culture medium . Positive_regulation RELA TNF 8046241 267023 In conclusion , a combination of adenosine and homocysteine selectively modulates TNF-alpha mediated cytotoxicity without changing the *induced* activation of [NF-kappa B] . Positive_regulation RELA TNF 8051093 267600 In HeLa cells , *induced* [NF-kappa B] activity . Positive_regulation RELA TNF 8051093 267608 Thus , we show that [NF-kappa B] activates p53 and that this activation is *inducible* by . Positive_regulation RELA TNF 8061120 268535 *activates* [nuclear factor kappa B (NF-kappa B)] and TGF-beta 1 does not . Positive_regulation RELA TNF 8074713 270571 In human astrocytoma and neuroblastoma cell lines and interleukin 1 beta (IL-1 beta) *induced* [NFKB] and an additional KB-specific protein of approximately 80 K to bind the HIV-1 enhancer . Positive_regulation RELA TNF 8076691 270637 Bcl-2 protects from oxidative damage and apoptotic cell death without interfering with *activation* of [NF-kappa B] by . Positive_regulation RELA TNF 8076691 270641 However , Bcl-2 had no effect on the *activation* of [NF-kappa B] by , even though it protected cells from TNF induced apoptosis . Positive_regulation RELA TNF 8096091 214533 Phorbol ester and *induction* of nuclear [NF-kappa B] is associated with both the degradation of performed I kappa B alpha and the activation of I kappa B alpha gene expression . Positive_regulation RELA TNF 8132572 251550 The participation of cell ceramide in *stimulated* [NF-kappa B] activation in Jurkat T cells and HL-60 cells was studied . Positive_regulation RELA TNF 8132572 251552 readily *stimulated* [NF-kappa B] activity in both cell lines as assayed by electrophoretic mobility shift assay and the use of a human immunodeficiency virus-chloramphenicol acetyltransferase reporter construct . Positive_regulation RELA TNF 8132572 251554 We conclude that *induced* [NF-kappa B] activation occurs in Jurkat and HL-60 cell lines that do not demonstrate an increase in TNF-alpha induced ceramide . Positive_regulation RELA TNF 8132572 251558 Increasing ceramide levels by the addition of short chain ceramides or the use of a glucosylceramide synthase inhibitor can be dissociated from *activation* of [NF-kappa B] by . Positive_regulation RELA TNF 8152812 253063 *Activation* of multiple [NF-kappa B/Rel] DNA binding complexes by . Positive_regulation RELA TNF 8182064 256466 By using receptor blocking antibodies we found that both p60 and p80 forms of TNF receptors were functional for NBT reducing activity , but dependent [NF-kappa B] *activation* required only the p60 receptor . Positive_regulation RELA TNF 8188652 256836 Various inhibitors of serine-like proteases are shown to block mediated [NF-kappa B] *activation* as well as the disappearance of I kappa B-alpha immunoreactivity in primary murine T lymphocytes and in various human leukemic cell lines . Positive_regulation RELA TNF 8207213 261390 Recent studies demonstrate that the sphingomyelinase-ceramide pathway plays a potential role in the *activation* of [nuclear factor-kappa B (NF-kappa B)] by . Positive_regulation RELA TNF 8253818 238391 Inability to induce NF-kappa B can not be due to a non-activatable system since [NF-kappa B] was strongly *activated* by in all the five primary cell types tested . Positive_regulation RELA TNF 8253818 238393 Conversely cysteine , an antioxidant and precursor of the free radical scavenger , glutathione , inhibited the *induction* of [NF-kappa B] by in primary cells , and by okadaic acid or tumor necrosis factor in transformed cells . Positive_regulation RELA TNF 8253818 238395 The *induction* of [NF-kappa B] by in primary cells suggests that this cytokine fulfills the requirement for oxidation , possibly by inducing the production of free radicals . Positive_regulation RELA TNF 8264646 247044 In Hs294T cells , gel shift analyses indicate that IL-1 and *induce* [NF-kappa B] complex formation ; Positive_regulation RELA TNF 8276464 247196 In addition , *induction* of [NF-kB] binding activity by the was accompanied by a decrease in nuclear factors that bind to the CRE II region . Positive_regulation RELA TNF 8282539 240631 Our results indicate that the potentiating effect of forskolin ( 50 microM ) on TNF mediated MCF7 cell lysis did not involve a modulation in the induced *activation* of the nuclear factor [NF-kB] but was associated with an increase in the DNA fragmenting capacity of TNF as assessed by agarose gel electrophoresis of target cell DNA . Positive_regulation RELA TNF 8283141 247456 Both and LPS *activated* the same [NF-kappa B] nuclear complexes , composed of the p50 and p65 subunits . Positive_regulation RELA TNF 8283141 247458 However , PDTC had a smaller inhibitory effect on LPS induced NF-kappa B activation and H-2 antigen expression , suggesting that and LPS *activate* [NF-kappa B] by somewhat different pathways . Positive_regulation RELA TNF 8298498 240956 Vitamin E derivatives have been shown to inhibit induced [NF-kappa B] *activation* in human Jurkat T cells . Positive_regulation RELA TNF 8344250 226435 This depletion of the mitochondrial oxidative metabolism resulted in resistance towards TNF cytotoxicity , as well as in inhibition of [NF kappa B] activation and interleukin-6 gene *induction* by . Positive_regulation RELA TNF 8349660 227105 In this cell line , *caused* potent activation of [nuclear factor-kappa B (NF-kappa B)] and exerted potent cytostatic/cytocidal activity . Positive_regulation RELA TNF 8349660 227107 C2-ceramide , however , enhanced activation of [NF-kappa B] in *response* to with peak effects observed at a concentration of C2-ceramide of 5 microM . Positive_regulation RELA TNF 8376408 229930 As shown previously , ( 1 nM ) induced a marked *increase* in nuclear [NF-kappa B] binding in human leukemia ( HL-60 ) cells within 5 min , and elevated binding was detected for as long as 1 h. Addition of a maximally effective concentration of sphingomyelinase , 0.1 units . ml-1 , induced a 50 % reduction in sphingomyelin content by 5 min from a basal level of 560 pmol.10 ( 6 ) cells-1 and a quantitative increase in ceramide levels from 89 pmol.10 ( 6 ) cells-1 . Positive_regulation RELA TNF 8409402 233342 Moreover , *induced* activation of [NF-kappa B-like] transcription factors was unaffected by altered levels of hsp70 as tested by electrophoretic mobility shift assay . Positive_regulation RELA TNF 8432991 212949 In addition , [NF-kappa B] binding activity was *induced* by these agents as was the secretion of . Positive_regulation RELA TNF 8495426 219514 At the biochemical level , staurosporine increased the *mediated* activation of phospholipases C and D and the transcription factor [NF-kappa B] in L929 cells . Positive_regulation RELA TNF 8521084 336408 However several questions regarding the molecular mechanisms involved in particular steps of these cascades remain largely unresolved : how and at which subcellular level , do the cells produce these reactive oxygen intermediates that will contribute to [NF kappa B] activation in *response* to IL-1 or ? Positive_regulation RELA TNF 8554902 337182 DFO also protected against PMA induced [NF-kappa B] activation as well as induced HIV-1 *activation* . Positive_regulation RELA TNF 8555009 340107 TPCK , a I kappa-B alpha protease inhibitor , was able to virtually abolish UV-induced TNF release , indicating that UV-induced release *requires* [NF-kappa B] activation . Positive_regulation RELA TNF 8565075 349083 can induce apoptosis and *activate* [NF-kappa B] through signaling cascades emanating from TNF receptor 1 (TNFR1) . Positive_regulation RELA TNF 8565075 349088 A TRAF2 mutant lacking its N-terminal RING finger domain is a dominant negative inhibitor of mediated [NF-kappa B] *activation* , but does not affect TNF induced apoptosis . Positive_regulation RELA TNF 8580820 342319 *induction* of [NF-kappa B] was abolished by antioxidants , suggesting involvement of the free radical pathway . Positive_regulation RELA TNF 8590321 342399 Upregulation of [NF-kappa B-dependent] gene expression *mediated* by the p75 receptor . Positive_regulation RELA TNF 8597871 342620 Furthermore , when equitoxic concentrations of anti-Fas antibody and TNF were applied , *triggered* a stronger [NF-kappa B] response . Positive_regulation RELA TNF 8598494 350748 We demonstrate that IL-1 and *induce* [rapid nuclear translocation of p65(RelA)] in T cell clones , whereas TCR induced NF-Kappa B activation in Th1 cells is delayed and may be longer in duration . Positive_regulation RELA TNF 8612692 353281 *induces* a rapid and transient activation of [NF-kappaB] in WEHI 164 cells which is followed by a second , long lasting phase in which the amount of NF-kappaB complex in the nucleus remains at about 50 % of maximum . Positive_regulation RELA TNF 8612692 353285 Calphostin C , on the other hand , can block the *activation* of [NF-kappaB] by , also blocking its proteolytic degradation . Positive_regulation RELA TNF 8621670 354296 Additionally , one of the TRADD mutants that fails to activate NF-kappaB was found to act as dominant negative mutant capable of preventing *induction* of [NF-kappaB] by . Positive_regulation RELA TNF 8621670 354299 Such observations provide evidence that TRADD performs an obligate role in induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 8626413 355702 Furthermore , *activation* of [NF-kappaB] by also results in repression of PR , while PR is able to repress tumor necrosis factor-alpha induced NF-kappaB activity . Positive_regulation RELA TNF 8627768 356048 The first was to abruptly terminate *induced* [NF-kappaB] binding to the enhancer sequences in U1 monocytic cells , using a short pulse of exogenous tumor necrosis factor . Positive_regulation RELA TNF 8647884 358687 We show that ER overload mediated NF-kappaB activation but not *stimulated* [NF-kappaB] induction can be inhibited by the intracellular Ca2+ chelator TMB-8 . Positive_regulation RELA TNF 8655581 366981 We report here that both kappa B-dependent transactivation of a reporter gene and [NF-kappa B] activation in *response* to tumor necrosis factor ( ) or H2O2 treatments are deficient in human T47D cell transfectants that overexpress seleno-glutathione peroxidase ( GSHPx ) . Positive_regulation RELA TNF 8662702 367191 additionally *caused* rapid p38 and JNK-1 mitogen activated protein kinase activation and efficient [NF-kappaB] translocation , which could not be achieved even by high levels of ceramide . Positive_regulation RELA TNF 8662753 367253 MEK kinase is involved in alpha *induced* [NF-kappaB] activation and degradation of IkappaB-alpha . Positive_regulation RELA TNF 8662753 367256 These results suggest that MEK kinase is a signal mediator involved in *induced* [NF-kappaB] activation and that the activation of NF-kappaB by MEK kinase is regulated through the degradation of IkappaB-alpha . Positive_regulation RELA TNF 8663191 368412 We conclude that *causes* persistent activation of [NF-kappaB] in human EC and that this may result from sustained reductions in IkappaB-beta levels . Positive_regulation RELA TNF 8683130 370273 Since ceramide has been shown to play a role in mediated *activation* of [nuclear factor-kappa B (NF-kappa B)] , we examined the effect of SR33557 on this early cellular response of TNF . Positive_regulation RELA TNF 8683130 370275 Surprisingly , this inhibitor of ceramide production was found to have no effect on mediated [NF-kappa B] *activation* , thus suggesting that SR33557-sensitive acidic SMase is not involved in this process . Positive_regulation RELA TNF 8697149 371013 Furthermore , *activated* the nuclear transcriptional factor [NF-kappa B] in both cell types , whereas anti-Fas had no effect . Positive_regulation RELA TNF 8699854 343306 also *induces* expression of human immunodeficiency virus ( HIV ) through activation of the transcription factor [NF-kappa B] , which binds to the viral long terminal repeat ( LTR ) . Positive_regulation RELA TNF 8710854 376585 TRAF2 is required for CD40- and mediated *activation* of the transcription factor [NF-kappa B] . Positive_regulation RELA TNF 8724035 373770 An enhanced [nuclear factor (NF)-kappa B] activation in *response* to has been observed in stably tat transfected cells . Positive_regulation RELA TNF 8724035 373774 Therefore , the possible association of a Tat autocrinous loop with the enhanced [NF-kappa B-binding] activity *induced* by in Tat producing cells was studied by anti-Tat antibody blocking experiments . Positive_regulation RELA TNF 8724035 373776 Permanently tat transfected Jurkat cells , maintained either in the presence or absence of anti-Tat antibody , were studied for the presence of *induced* [NF-kappa B-binding] activity ( quantified by electrophoretic mobility shift assays ) and the presence of cell-surface bound Tat ( determined by flow cytometry and confocal microscopy of anti-Tat immunofluorescence stained cell preparations . Positive_regulation RELA TNF 8724035 373778 The enhanced production of TNF-alpha induced NF-kappa B binding activity exhibited by tat transfected Jurkat cells was completely abolished in cell cultures maintained in the presence of anti-Tat antibody , thus indicating that the increased *induced* [NF-kappa B] binding activity observed in Jurkat-tat cells was dependent on the presence of Tat protein in an antibody-accessible location . Positive_regulation RELA TNF 8760145 378031 *increased* [nuclear factor (NF)-kappa B-DNA] binding , an effect blocked by pretreatment with NAC . Positive_regulation RELA TNF 8772190 379411 Two distinct intracellular Ca2+ chelators and a panel of structurally unrelated antioxidants prevented NF-kappaB activation by various ER stress eliciting agents , whereas only antioxidants but not the Ca2+ chelators prevented [NF-kappaB] *activation* by the inflammatory cytokine . Positive_regulation RELA TNF 8790599 291139 The mechanism of inhibitory action of PTX on virus replication and NF-kappa B-induced transactivation of HIV-1 gene expression has been elucidated as due to blocking PKC dependent PMA- or induced *activation* of [NF-kappa B] in Jurkat and 293-27-2 cells . Positive_regulation RELA TNF 8798772 381883 and lymphotoxin alpha ( LTalpha , originally TNFbeta ) are potent [nuclear factor kappaB (NFkappaB)] *activators* in various cell types . Positive_regulation RELA TNF 8799159 381941 Our results show that the *activation* of [NF-kappa B] by is completely blocked by CAPE in a dose- and time dependent manner . Positive_regulation RELA TNF 8805640 382276 Overall , our results clearly demonstrate that the *activation* of [NF-kappa B] and cytotoxicity by is differentially regulated through the p60 receptor . Positive_regulation RELA TNF 8822344 384839 HTLV-I tax protein and *induced* activation of [NF-kappa B] in apoptotic MC3T3-E1 cells . Positive_regulation RELA TNF 8830655 385504 We found that binding of [NFkappaB] is strongly *induced* in mesangial cells by both IL-1beta and . Positive_regulation RELA TNF 8831497 385730 However , the intracellular signaling pathways that activate endothelial [NF-kappa B] and JNK in *induced* responses are unknown . Positive_regulation RELA TNF 8832978 385887 Our data suggest that TNF-alpha induces expression of proinflammatory cytokines such as IL-8 and MCP-1 through generation of reactive oxygen intermediates and subsequent activation of NF-kappa B in human synovial cells , and the antioxidants may inhibit , at least in part , the *activation* of [NF-kappa B] by . Positive_regulation RELA TNF 8844707 387569 *activated* [nuclear factor kappa B (NF kappa B)] in HBMEC . Positive_regulation RELA TNF 8849369 359029 To examine whether [nuclear factor kappaB (NF-kappaB)] is activated in cultured synovial cells in *response* to and to investigate the correlation between NF-kappaB activation and synovial cell proliferation . Positive_regulation RELA TNF 8849369 359033 Stimulation of synovial cells with *activated* [NF-kappaB] and subsequent transcription of several genes . Positive_regulation RELA TNF 8849369 359035 Treatment of synovial cells with N-acetyl-L-cysteine (NAC) , an antioxidant agent , inhibited induced [NF-kappaB] *activation* and transcription . Positive_regulation RELA TNF 8852698 387843 Analysis of DNA binding revealed that [NF-kappa B] activation in *response* to was significantly inhibited under these conditions . Positive_regulation RELA TNF 8863511 388844 Here , we describe that both IL-1 beta and *activate* the transcription factor [nuclear factor-kappa B (NF-kappa B)] via production of reactive oxygen intermediates resulting in ACT expression . Positive_regulation RELA TNF 8864119 388933 The *activation* of the transcription factor [nuclear factor-kappa B (NF-kappaB)] by , ionizing radiation , or daunorubicin ( a cancer chemotherapeutic compound ) , was found to protect from cell killing . Positive_regulation RELA TNF 8870842 389484 HIV type 1 glycoprotein 120 amplifies *induced* [NF-kappa B] activation in Jurkat cells . Positive_regulation RELA TNF 8870842 389486 In CD4 positive Jurkat cells , gp120 potentiates induced [NF-kappa B] *activation* . Positive_regulation RELA TNF 8870842 389488 mediated *activation* of [NF-kappa B] is known to involve the intracellular formation of reactive oxygen intermediates ( ROIs ) . Positive_regulation RELA TNF 8870842 389490 In contrast , in the p56lck-deficient J.CaM1.6 T cell line , a derivative of the Jurkat cell line , gp120 was unable to stimulate hydrogen peroxide , to decrease the ratio of GSH to GSSG , and has no effect on induced [NF-kappa B] *activation* . Positive_regulation RELA TNF 8870842 389492 Taken together , our data suggest that gp120 potentiates induced [NF-kappa B] *activation* by stimulating a signal pathway that involves p56lck and the increased formation of reactive oxygen intermediates such as H2O2 . Positive_regulation RELA TNF 8873967 389863 These results indicate that nuclear translocation and *activation* of [NF-kappa B] through generated ceramide may be one important apoptotic signaling pathway in MC3T3-E1 cells . Positive_regulation RELA TNF 8900181 393449 Electrophoretic mobility shift assays with nuclear extracts of A3 cells showed that stimulation with ATRA and for more than 16 h *resulted* in enhanced [NF-kappaB] binding compared to that induced by TNF-alpha alone . Positive_regulation RELA TNF 8940176 399128 and interferon-gamma *induced* [NF-kappaB] ( p50/p65 ) and STAT-1 , respectively , as assessed by gel shift assays . Positive_regulation RELA TNF 8943045 399480 The association of TRADD , a 34-kDa cytoplasmic protein containing a C-terminal death domain , with aggregated through their respective death domains *leads* to [NF-kappa B] activation and programmed cell death . Positive_regulation RELA TNF 8947041 400455 We have created mutant cell lines that are unable to activate [NF-kappaB] in *response* to . Positive_regulation RELA TNF 8995233 409351 Our results demonstrated that the mutated IkappaB alpha was stably expressed in the transfected MCF7 cells and blocked the *induced* [NF-kappaB] nuclear translocation . Positive_regulation RELA TNF 9013701 411792 In a stable mouse L cell clone , L-15 , [NF-kappaB] DNA binding activity *induced* by uv-C ( 254 nm ) but not by or 12-O-tetra-decanoylphorbol-13-acetate ( TPA ) correlated with the stimulation of HIV-LTR directed chloramphenicol acetyltransferase (CAT) activity ; Positive_regulation RELA TNF 9038369 415552 Moreover this glucocorticoid did not suppress the *induced* increase of [NF-kappaB] binding activity . Positive_regulation RELA TNF 9042860 416133 We also show that *activation* of [NF-kappaB] by depends on CDC42 and RhoA , but not Rac-1 proteins , because this activity is drastically inhibited by their respective dominant negative mutants . Positive_regulation RELA TNF 9053449 417234 Involvement of Egr-1/RelA synergy in distinguishing T cell activation from *induced* [NF-kappa B1] transcription . Positive_regulation RELA TNF 9065470 418211 The activation of NF-kappaB by fMLF appeared to be cell-specific and different from the *activation* of [NF-kappaB] by . Positive_regulation RELA TNF 9099747 422877 The sphingomyelin pathway is thought to mediate the induced *activation* of [NF-kappaB] by its second messenger ceramide . Positive_regulation RELA TNF 9099747 422879 Here we present experimental evidence that acid sphingomyelinase is not involved in the induced *activation* of [NF-kappaB] . Positive_regulation RELA TNF 9110146 424996 Iron chelation decreases human immunodeficiency virus-1 Tat potentiated induced [NF-kappa B] *activation* in Jurkat cells . Positive_regulation RELA TNF 9110146 424998 *mediated* activation of [NF-kappa B] is known to involve the intracellular formation of reactive oxygen intermediates ( ROIs ) . Positive_regulation RELA TNF 9110146 425000 We recently demonstrated that HIV-1 Tat protein potentiates *induced* [NF-kappa B] activation by downregulation of manganese dependent superoxide dismutase ( MnSOD ) , shifting the cellular redox state towards pro-oxidative conditions . Positive_regulation RELA TNF 9110146 425002 This study shows that treatment of Jurkat cells with iron chelator deferoxamine ( DFO ) strongly decreases HIV-1 Tat potentiated induced [NF-kappa B] *activation* but does not modify NF-kappa B activation by TNF-alpha . Positive_regulation RELA TNF 9110146 425004 The ability of iron chelators to reduce Tat potentiated *induced* [NF-kappa B] binding activity suggests that iron and intracellular hydroxyl radicals ( OH. ) are required for Tat effect . Positive_regulation RELA TNF 9110146 425006 markedly enhanced induced [NF-kappa B] *activation* in a dose dependent manner while was not sufficient to trigger activation of NF-kappa B by itself . Positive_regulation RELA TNF 9110146 425008 in the presence of iron ions play a major role in HIV-1 Tat enhancement of *induced* [NF-kappa B] activation and that iron chelation may protect Jurkat T cells , at least in part , against oxidative stress induced by Tat . Positive_regulation RELA TNF 9115810 419248 Ascorbate and AZT also had no effect on [NF-kappa B] *activation* following or PMA induced stimulation of U1 promonocytic cells . Positive_regulation RELA TNF 9122255 423976 Contrary to the results in Jurkat cells , PDTC did not inhibit induced [NF kappaB] *activation* in astrocytes ; Positive_regulation RELA TNF 9126284 426480 This pretreatment also inhibited activation of [NF-kappa B] in *response* to in lymphoblastoid J.Jhan5-1 cells . Positive_regulation RELA TNF 9139689 428182 and hydrogen peroxide , in contrast , *led* to [NF-kappaB] activation but only modestly stimulated p38 . Positive_regulation RELA TNF 9149909 430097 Secreted *mediated* the enhancement of [nuclear factor kappa B (NF-kappa B)] and activator protein-1 (AP-1) binding activity ; Positive_regulation RELA TNF 9153285 431293 *initiates* [NF-kappaB] nuclear translocation by causing dissociation of the inhibitory protein I-kappaBalpha from NF-kappaB and rapid degradation of I-kappaBalpha . Positive_regulation RELA TNF 9168973 432691 Moreover , we have shown that while an intracellular calcium chelator BAPTA/AM was able to inhibit both SPP- and TG-induced NF-kappa B activation , it had no effect on induced [NF-kappa B] *activation* . Positive_regulation RELA TNF 9176246 433698 The GR antagonist RU-486 inhibited the repressive effect of Dex on *induced* [NF-kappa B] activity by 81 % but only counteracted the repressive effect of Dex on TPA induced AP-1 activity by 43 % . Positive_regulation RELA TNF 9185524 436714 The constitutive and *induced* [NF-kappaB/Rel] complexes were identical and were composed mainly of p50 and c-Rel proteins . Positive_regulation RELA TNF 9185524 436717 These results indicate that the aberrant , constitutive GM-CSF gene activation in JMML is maintained by mediated *activation* of [NF-kappaB/Rel] proteins . Positive_regulation RELA TNF 9195956 438331 ( vi ) Ceramide generation in response to Fas activation was inhibited by N-acetyltyrosinylvalinylalanylaspartyl chloromethyl ketone , a peptide inhibitor of interleukin-1beta converting enzyme-like proteases , whereas induced [NF-kappaB] *activation* was unaffected by the inhibitor . Positive_regulation RELA TNF 9199898 439033 SAC consistently exhibited a dose dependent inhibition of [NF-kappa B] activation *induced* by both and H2O2 . Positive_regulation RELA TNF 9224625 441843 AFR behaves like ascorbate , while DHA and ascorbate phosphate do not affect mediated [NF-kappaB] *activation* . Positive_regulation RELA TNF 9237663 445679 Inhibition of protein tyrosine phosphatases blocks induced growth modulation and [NF-kappaB] *activation* , both mediated primarily through the p60 TNF receptor . Positive_regulation RELA TNF 9237663 445682 Taken together , these results suggest that protein tyrosine phosphatases play an essential role in phosphorylation of the cytoplasmic domain of the TNF receptor and in regulation of the receptor associated kinase , and this in turn may play a role in mediated growth modulation and [NF-kappaB] *activation* . Positive_regulation RELA TNF 9244310 446244 *Activation* of the transcription factor [NF-kappaB] by and interleukin-1 (IL-1) requires the NF-kappaB inducing kinase (NIK) . Positive_regulation RELA TNF 9268159 449764 N-Acetylcysteine (NAC) , pyrrolidinedithiocarbamate ( PDTC ) , and Trimidox ( TD ) at various concentrations inhibited *induced* [NF-kappaB] binding in Jurkat cells . Positive_regulation RELA TNF 9268159 449766 On the other hand , iron chelators desferrioxamine , pyridoxal isonicotinoyl hydrazone (PIH) , and salicylaldehyde isonicotinoyl hydrazone ( SIH ) showed no inhibition of *induced* [NF-kappaB] DNA binding activity . Positive_regulation RELA TNF 9275204 450669 *induced* activation of the transcription factor [NF-kappaB] and the c-jun N-terminal kinase ( JNK/SAPK ) requires TNF receptor associated factor 2 (TRAF2) . Positive_regulation RELA TNF 9277478 450782 Electrophoretic mobility-shift assays of HUVEC nuclear proteins revealed a decrease in *stimulated* [nuclear factor-kappa B (NF-kappa B)] activation after pretreatment of HUVEC with TCP succinate but not with TCP , TCP acetate , or succinate alone . Positive_regulation RELA TNF 9294162 452904 In contrast to wild-type c-IAP2 , a mutant lacking the C-terminal RING domain inhibits [NF-kappaB] *induction* by and enhances TNF killing . Positive_regulation RELA TNF 9299419 453452 Glutathione regulation of induced [NF-kappa B] *activation* in skeletal muscle derived L6 cells . Positive_regulation RELA TNF 9299419 453458 Results from GSSG reductase inhibited cells suggest that GSSG may participate in , but is not required for , *induced* [NF-kappa B] activation . Positive_regulation RELA TNF 9312187 455485 *potentiated* [NF-kappaB] translocation into the nucleus and stimulated apoptosis in isolated acini while not affecting LDH release . Positive_regulation RELA TNF 9317150 456277 Transient overexpression of the TRAF2 adaptor protein can activate NF-kappaB and endogenous JNK , whereas N-terminal truncated TRAF2 protein blocks *induced* [NF-kappa B] and JNK activation as well as E-selectin promoter-reporter gene transcription . Positive_regulation RELA TNF 9317150 456293 These data suggest that *activates* parallel [TRAF-NF-kappa B] and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways to initiate E-selectin transcription . Positive_regulation RELA TNF 9325328 456920 Lipid peroxidation is involved in the *activation* of [NF-kappaB] by but not interleukin-1 in the human endothelial cell line ECV304 . Positive_regulation RELA TNF 9325328 456950 Here we have investigated the effect of a range of putative antioxidants on [NF-kappaB] *activation* by interleukin-1 and as well as the ability of H2O2 to activate NF-kappaB in primary human umbilical vein endothelial cells and the transformed human endothelial cell line ECV304 . Positive_regulation RELA TNF 9325328 456978 Finally , butylated hydroxyanisole , which inhibits lipid peroxidation but has no iron chelating properties , inhibited [NF-kappaB] *activation* by but not interleukin-1 . Positive_regulation RELA TNF 9325328 457008 Furthermore , and interleukin-1 *activate* [NF-kappaB] through different mechanisms in ECV304 cells , with the tumor necrosis factor pathway involving iron catalyzed lipid peroxidation . Positive_regulation RELA TNF 9332715 457652 The oxidative stress responsive transcription factor [nuclear factor-kappa B (NF-kappa B)] consists of a p50 ( 50 kDa ) and p65/RelA ( 65 kDa ) component and can be *activated* in vitro by , IL1 beta , hydrogen peroxide and oxygen radicals . Positive_regulation RELA TNF 9341756 458757 Recent studies from our laboratory have indicated that protein tyrosine phosphatase ( PTPase ) inhibitors can down-modulate the mediated *activation* of the nuclear transcription factor [NF-kappa B] in ML-1a , a monocytic cell line ( Singh and Aggarwal , J. Biol. Chem. 1995 : 270 : 10631 ) . Positive_regulation RELA TNF 9341756 458760 Besides PAO , other inhibitors of PTPase , including pervanadate and diamide , also blocked dependent [NF-kappa B] *activation* and induction of all the three adhesion proteins . Positive_regulation RELA TNF 9343439 459033 However , since *activation* of [NF-kappaB] by is often transient and would not activate long-term kappaB dependent transcription effectively , we explored the effects of IFN-gamma on TNF-alpha induced NF-kappaB activity . Positive_regulation RELA TNF 9343439 459038 IFN-gamma , which typically does not activate NF-kappaB , synergistically enhanced *induced* [NF-kappaB] nuclear translocation via a mechanism that involves the induced degradation of I kappaBbeta and that apparently requires tyrosine kinase activity in preneuronal cells but not in endothelial cells . Positive_regulation RELA TNF 9346915 459569 In this cell line ( EL4D6/76 ) , *induced* ligand/receptor internalization , [NFkappaB] nuclear translocation , IL-2 production , and the activation of neutral (N)-SMase and acid ( A ) -SMase . Positive_regulation RELA TNF 9351451 461146 In electrophoretic mobility shift assays , *activated* [nuclear factor-kappa B (NF-kappa B)] with a peak at approximately 3 hours , whereas pulsatile stretch showed sustained activation during stimulation for up to 24 hours . Positive_regulation RELA TNF 9351830 466078 Microinjection of the inhibitory peptides into stimulated cells abolished [NF-kappa B] activation in *response* to and the consequent expression of E-selectin , an NF-kappa B-dependent cell-adhesion molecule . Positive_regulation RELA TNF 9374527 465151 Despite *activation* of [nuclear factor-kappaB (NF-kappaB)] by , this transcription factor was not required for TNF induced transcription of gamma-GCS-HS as revealed by deletion constructs of the gamma-GCS-HS promoter subcloned in a chloramphenicol acetyltransferase reporter vector and transfected into HepG2 cells . Positive_regulation RELA TNF 9383399 345226 Cell lines stably overexpressing the H2O2 degrading enzyme catalase were deficient in activating [NF-kappa B] in *response* to or okadaic acid . Positive_regulation RELA TNF 9388244 466787 The induction of vascular cell adhesion molecule-1 ( VCAM-1 ) expression by *requires* the activation of [nuclear factor-kappaB (NF-kappaB)] via a process involving the phosphorylation and degradation of its cytoplasmic inhibitor , IkappaBalpha . Positive_regulation RELA TNF 9388244 466792 *Activation* of [NF-kappaB] by occurred within 15 min and coincided with rapid degradation of IkappaBalpha . Positive_regulation RELA TNF 9394802 468205 These data suggest that PAF , which is released immediately or shortly after LPS injection , *induces* the expression of through the activation of [NF-kappa B] . Positive_regulation RELA TNF 9405407 469818 Finally , interference with GCKR expression impeded TRAF2- and *induced* SAPK activation but not that of [NF-kappaB] . Positive_regulation RELA TNF 9417872 472287 Expression of bcl-2 did not impose a block to , or potentiate , signaling of I kappa B alpha degradation , nuclear import of the RelA p65 , or [NF-kappa B-dependent] *transactivation* . Positive_regulation RELA TNF 9418855 480460 *Activation* of [NF-kappaB] by and IL-1 is initiated by the phosphorylation of the inhibitory subunit , IkappaB , which targets IkappaB for degradation and leads to the release of active NF-kappaB . Positive_regulation RELA TNF 9418855 480463 The nonsteroidal anti-inflammatory drug sodium salicylate ( NaSal ) interferes with *induced* [NF-kappaB] activation by inhibiting phosphorylation and subsequent degradation of the IkappaB alpha protein . Positive_regulation RELA TNF 9427646 481713 In addition , GFP-DeltaFADD did not interfere with mediated gene induction or with *activation* of [NF-kappaB] or Jun N-terminal kinase (JNK) , demonstrating that FADD is part of the TNFR60 initiated apoptotic pathway but does not play a role in TNFR60 mediated gene induction . Positive_regulation RELA TNF 9430229 474417 The C-terminus of MyD88 interacts with the IL-1 receptor and blocks [NF-kappaB] activation *induced* by IL-1 , but not by . Positive_regulation RELA TNF 9435375 474696 In TNF-alpha and GC target cell lines , it was found that : 1 ) TNF-alpha enhanced GR number in L-929 cells , and 2 ) by transfection of these cells with a reporter plasmid carrying the GR promoter , that TNF-alpha induced increase in GR is at the transcriptional level , 3 ) by electrophoretic mobility shift assay , using nuclear extracts of TNF-alpha ( 0.02 ng/ml ) or TNF-alpha plus DEX ( 10 nM ) stimulated L-929 cells , that cytokines can increase the binding of GR to GRE ( 45 min , 1.8 x ) , while the *induced* [NFkB] factor expression was not affected by GC . Positive_regulation RELA TNF 9439980 475067 Curcumin inhibits IL1 alpha and *induction* of AP-1 and [NF-kB] DNA binding activity in bone marrow stromal cells . Positive_regulation RELA TNF 9439980 475079 IL1 alpha and rapidly *induced* both AP-1 and [NF-kB] DNA binding activities in +/+ ( - ) 1.LDA11 stromal cells . Positive_regulation RELA TNF 9439980 475086 These data suggest that inhibition of MCP-1/JE transcription by curcumin involves blocking of AP-1 and [NF-kB] *activation* by IL1 alpha or . Positive_regulation RELA TNF 9442373 475192 We found that removal of the containing medium *causes* a rapid decrease in nuclear [NF-kappa B] . Positive_regulation RELA TNF 9454839 484408 Furthermore , unlike TNF-alpha treatment , NGF treatment did not significantly activate JNK , although both and NGF *induced* nuclear translocation of [NF-kappaB] . Positive_regulation RELA TNF 9458713 484608 In bovine aorta and bovine pulmonary artery endothelial cells , *activated* [nuclear factor (NF)-kappa B] . Positive_regulation RELA TNF 9466577 485600 The activation of sphingomyelinase and the generation of ceramide has been proposed to mediate induced [nuclear factor (NF)-kappaB] *activation* through its second messenger ceramide . Positive_regulation RELA TNF 9466577 485602 was shown to *activate* [NF-kappaB] ( p65 translocation and degradation of IkappaBalpha ) and the stress kinase pathway ( phosphorylation of ATF-2 , p38 , and c-jun ) . Positive_regulation RELA TNF 9466577 485604 Thus , although *stimulates* the [NF-kappaB] and stress kinase pathways in HSF , these effects of TNF-alpha are not associated with sphingomyelinase turnover or induction of apoptosis . Positive_regulation RELA TNF 9468519 486083 In gel mobility supershift assays , the antibodies to c-Fos or c-Jun inhibited the binding of *activated* nuclear [NF-kappaB] to the kappaL-kappaR , suggesting that both c-Fos and c-Jun interacted with NF-kappaB . Positive_regulation RELA TNF 9479002 487178 [NF-kappaB] activation *induced* by , as detected by mobility shift assays or by transfection of kappaB-driven reporter genes , is impaired in African swine fever virus infected cells . Positive_regulation RELA TNF 9486215 488327 By EMSA , TPA and *increased* nuclear [NF-kappa B] binding activity in temporally distinct patterns . Positive_regulation RELA TNF 9486215 488329 PDTC decreased TPA- and *induced* [NF-kappa B] binding activity but did not limit their inhibition of SP-A and SP-B mRNAs . Positive_regulation RELA TNF 9486659 488354 Furthermore , *induced* [NF-kappaB] DNA binding activity was inhibited in the population of endothelial cells expressing IkappaBdeltaN . Positive_regulation RELA TNF 9497357 490361 Moreover , the activation of [nuclear factor kappaB (NFkappaB)] *induced* by extracellularly added H2O2 or was blocked by overproduction of Prx II . Positive_regulation RELA TNF 9500555 490825 Transfection of a truncated Peg3 containing the TRAF2 interaction site , abolishes [NFkappaB] *activation* by TRAF2 and/or . Positive_regulation RELA TNF 9501011 491005 We demonstrate that adenovirus mediated overexpression of I kappa B alpha , an inhibitor of [NF-kappa B] suppresses the expression of piap in *response* to suggesting that piap is one of the NF-kappa B regulated genes that operates to prevent programmed cell death of EC in inflammation . Positive_regulation RELA TNF 9506462 491342 dependent *activation* of [NF-kappaB] could be blocked partially by both anti-p60 and anti-p80 , suggesting that TNF mediates its effect independently through the p60 and p80 receptors . Positive_regulation RELA TNF 9506955 491504 Two closely related IkappaBalpha kinases as well as the upstream kinase , NIK , which integrates interleukin-1beta (IL-1beta)- and dependent *activation* of the transcription factor [NF-kappaB] have recently been described . Positive_regulation RELA TNF 9520401 493506 A previously identified NF-kappaB inducing kinase (NIK) , which mediates [NF-kappaB] *activation* by and IL-1 , has been demonstrated to activate IKKalpha . Positive_regulation RELA TNF 9520446 493642 A mutant form of IKK-alpha containing alanine at residue 176 can not be phosphorylated or activated by NIK and acts as a dominant negative inhibitor of interleukin 1- and *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 9528954 496223 These results strongly suggest that *increases* the IL-6 gene expression through the activation of [NF-kappaB] in the thyroid cells , and that antioxidants suppress the TNF-alpha dependent IL-6 expression by inhibiting the activation of the transcriptionally active NF-kappaB . Positive_regulation RELA TNF 9529147 496492 The death domain kinase RIP mediates the *induced* [NF-kappaB] signal . Positive_regulation RELA TNF 9548505 477738 Similar potentiation of *induced* [NF-kappaB] activity and E-selectin transcription by thrombin was observed in experiments utilizing luciferase reporter constructs expressed in bovine aortic EC . Positive_regulation RELA TNF 9557650 499929 Furthermore , we observed that the core protein blocked the induced *activation* of [RelA/NF-kappaB] in murine BC10ME cells , thus at least partially accounting for the increased sensitivity of BC10ME cells to TNF . Positive_regulation RELA TNF 9560343 500498 Dominant negative mutants of several factors that play a key role in [NF-kappaB] *induction* by [ 10 ] inhibited NF-kappaB activation by Apo3L . Positive_regulation RELA TNF 9565556 500913 Interestingly , both the potent physiological inducer of NF-kappaB as well as endoplasmic reticulum overload can *induce* [NF-kappaB] via a PDTC sensitive pathway . Positive_regulation RELA TNF 9570554 501586 Simultaneously applied H2O2 strongly potentiated the PDBu- or *induced* transcriptional activity of [NF-kappa B] . Positive_regulation RELA TNF 9580637 504956 Because the PGHS-2 promoter has a nuclear factor-kappa B (NF-kappa B) binding motif , which is important for PGHS-2 gene transcription in some cell types , we have evaluated the effects of tyrosine kinase inhibitors and PAO on induced [NF-kappa B] *activation* . Positive_regulation RELA TNF 9580637 504959 N-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) , a serine protease inhibitor , inhibited I kappa B-alpha degradation and [NF-kappa B] activation in *response* to in a dose dependent manner ( 25 , 50 , 100 microM ) . Positive_regulation RELA TNF 9580637 504972 These data demonstrate that tyrosine kinase pathways are not required for *induced* [NF-kappa B] activation in MCA-101 cells and suggest that signaling via these pathways mediates TNF-alpha induced PGHS-2 mRNA accumulation via an NF-kappa B-independent mechanism . Positive_regulation RELA TNF 9581775 503478 Inhibition of *induced* [NF-kappaB] activation using the antioxidant N-acetylcysteine (NAC) resulted in increased apoptosis in both U937 and U9-IIIB cells , while preactivation of NF-kappaB with the non-apoptotic inducer IL-1beta caused a relative decrease in apoptosis . Positive_regulation RELA TNF 9582369 504192 Overexpression of manganese superoxide dismutase ( Mn-SOD ) in human breast cancer MCF-7 cells completely abolished mediated [NF-kappaB] *activation* , IkappaB alpha degradation , p65 nuclear translocation , and NF-kappaB dependent reporter gene expression . Positive_regulation RELA TNF 9586949 504570 As the induction of various adhesion molecules by *requires* activation of the transcription factor [NF-kappaB] , the effect of curcumin on the activation of this factor in the EC was also investigated . Positive_regulation RELA TNF 9588901 504695 [NF-kappaB] activation during IgG immune complex induced lung injury : *requirements* for and IL-1beta but not complement . Positive_regulation RELA TNF 9593751 505811 *activated* [NF-kappaB] in Jurkat cells but not in HuT-78 cells . Positive_regulation RELA TNF 9636658 513396 The role of DNA-PK , a protein kinase involved in the response to DNA damage , in the *activation* of [NF kappa B] by IR and was examined . Positive_regulation RELA TNF 9636658 513410 In M059J cells , which do not express DNA-PK , IR did not activate NF kappa B , whereas *induction* of [NF kappa B] was still observed . Positive_regulation RELA TNF 9636658 513420 These results indicate that DNA-PK participates in the *activation* of [NF kappa B] by IR but not by . Positive_regulation RELA TNF 9642107 514182 At 150 microM LA-Plus , but not LA , inhibited *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 9647248 514969 Remarkably , TRAF2-DN overexpression , which was found to inhibit the TNF dependent recruitment of endogenous wild-type TRAF2 to the TNF-R75 signaling complex , could neither block TNF-R55- or *induced* [NF-kappaB] activation nor granulocyte/macrophage-CSF secretion . Positive_regulation RELA TNF 9647248 514971 Possibly , additional factors different from TRAF2 are involved in mediated [NF-kappaB] *activation* . Positive_regulation RELA TNF 9657527 516812 *activated* binding of [nuclear factor kappaB (NF-kappaB)] to its targeted DNA sequence and stimulated degradation of I-kappaBalpha , an NF-kappaB inhibitory protein . Positive_regulation RELA TNF 9660769 517436 *induced* cell killing and activation of transcription factor [NF-kappaB] are uncoupled in L929 cells . Positive_regulation RELA TNF 9698598 524959 Inhibition of *induced* [NF-kappaB] activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132 . Positive_regulation RELA TNF 9698598 524962 The working hypothesis of the studies described herein was that inhibition of proteasome mediated IkappaB degradation would inhibit *induced* [nuclear factor-kappaB (NF-kappaB)] activation , interleukin-8 (IL-8) gene transcription , and IL-8 protein release in A549 cells . Positive_regulation RELA TNF 9705938 526115 TNFR-1 recruits and assembles a signaling complex containing a number of death domain ( DD ) -containing proteins , including the adaptor protein TRADD and the serine/threonine kinase RIP , which mediates induced [NF-kappa B] *activation* . Positive_regulation RELA TNF 9707608 526464 The Epstein-Barr virus oncoprotein latent infection membrane protein 1 ( LMP1 ) is a constitutively aggregated that *activates* transcription factor [NF-kappaB] through two sites in its C-terminal cytoplasmic domain . Positive_regulation RELA TNF 9710149 526624 We demonstrate that 0.1-0.5 microM DMDTC inhibits induced *activation* of [NF-kappaB] in primary human CD4+ T cells . Positive_regulation RELA TNF 9710205 526632 High doses of NO impaired the *induced* DNA binding activity of [NF-kappaB] . Positive_regulation RELA TNF 9718198 528187 These results suggest that the rapid activation of NF-kappaB by is mainly due to the nuclear translocation of NF-kappaB pre existing in cytosol , and that the subsequent increase in the expression of p50 and p65 may *result* in the persistent activation of [NF-kappaB] during TNF-alpha stimulation . Positive_regulation RELA TNF 9718198 528202 These results suggest that the *activation* of [NF-kappaB] by may play an important role in the production of cytokines and cell adhesion molecules from osteoblasts , leading to the promotion of bone resorption and inflammation . Positive_regulation RELA TNF 9720648 528506 Our analyses of the induction of nuclear factor-kappaB (NFkappaB) in activated memory ( CD45RO+ ) and naive ( CD45RA+ ) T cell subsets from young and elderly donors has demonstrated that , regardless of donor age , memory T cells are not significantly altered in their responsiveness to mediated *induction* of [NFkappaB] . Positive_regulation RELA TNF 9727370 529923 Electrophoretic mobility shift assays ( EMSA ) showed that interleukin-1beta and *activated* [NF-kappaB] from 15 min to 48 h after stimulation . Positive_regulation RELA TNF 9728048 530015 E-selectin expression in human endothelial cells by induced oxidant generation and [NF-kappaB] *activation* . Positive_regulation RELA TNF 9728048 530017 Pretreatment with N-acetyl-L-cysteine (NAC) or pyrrolidine dithiocarbamate ( PDTC ) for 0.5 h inhibited induced generation of ROS as well as *activation* of [NF-kappaB] and E-selectin mRNA and the cell surface protein expression . Positive_regulation RELA TNF 9728048 530028 These findings indicate that *induces* [NF-kappaB] activation and the resultant E-selectin gene expression by a pathway that involves formation of ROS and that E-selectin expression can be inhibited by the antioxidant action of NAC or PDTC . Positive_regulation RELA TNF 9729336 530131 Methylprednisolone inhibition of expression and [NF-kB] *activation* after spinal cord injury in rats . Positive_regulation RELA TNF 9731570 530494 Administration of uridine ( 1,000 mg/kg ) did not reduce plasma levels of and KC , [NF-kappaB] *activation* , or polymorphonuclear leukocyte sequestration , but attenuated apoptosis by 90 % to 94 % . Positive_regulation RELA TNF 9733516 530713 binding to the TNF receptor (TNFR) potentially initiates apoptosis and *activates* the transcription factor [nuclear factor kappa B (NF-kappaB)] , which suppresses apoptosis by an unknown mechanism . Positive_regulation RELA TNF 9737713 531579 Overexpression of BRE inhibited induced [NFkappaB] *activation* , indicating that the interaction of BRE protein with the cytoplasmic region of p55 TNF receptor may modulate signal transduction by TNF-alpha . Positive_regulation RELA TNF 9742107 532185 Such a NIK-T559A mutant also dominantly interferes with *induction* of [NF-kappaB] . Positive_regulation RELA TNF 9742107 532187 When expressed alone , this C-terminal NIK fragment functions as a potent inhibitor of *mediated* induction of [NF-kappaB] and alone is sufficient to disrupt the physical association of NIK and IKKalpha . Positive_regulation RELA TNF 9743347 532405 Pretreatment of cells with IL-13 blocked induced [NF-kappa B] *activation* , nuclear translocation of p65 subunit , and degradation of I kappa B alpha . Positive_regulation RELA TNF 9743347 532411 *induced* [NF-kappa B-dependent] gene transcription was also blocked by IL-13 . Positive_regulation RELA TNF 9743347 532425 Thus , overall , these results demonstrate that IL-13 is a potent inhibitor of mediated *activation* of [NF-kappa B] , AP-1 , and apoptosis , which may contribute to its previously described immunosuppressive and anti-inflammatory effects . Positive_regulation RELA TNF 9743348 532482 Electrophoretic mobility shift assay showed that alpha-MSH completely abolished mediated [NF-kappa B] *activation* in a dose- and time dependent manner . Positive_regulation RELA TNF 9743348 532484 This correlated with suppression of [NF-kappa B-dependent] reporter gene expression *induced* by . Positive_regulation RELA TNF 9743348 532486 Similarly , addition of membrane-permeable dibutyryl cAMP , like alpha-MSH , suppressed induced [NF-kappa B] *activation* . Positive_regulation RELA TNF 9755059 535281 ActD did not affect induced hepatocyte [NF-kappaB] *activation* but decreased NF-kappaB dependent gene expression . Positive_regulation RELA TNF 9755853 535705 [NF-kappaB] binding was rapidly *induced* by IL-1alpha or but was neither induced nor potentiated by bFGF or PDGF . Positive_regulation RELA TNF 9758167 535982 The existence of a synergism between IFN-gamma and TNF-alpha in stimulating IRF-1 expression at the transcriptional level was supported by IRF-1 promoter analysis : IFN-gamma directly induced the binding of STAT-1 homodimers to the GAS element , while [NF-kappaB] binding to the kappaB sequence was *activated* by only after IFN-gamma treatment . Positive_regulation RELA TNF 9759860 536554 We show that induced *activation* of [NF-kappaB] was inhibited by the well-known selective inhibitors of cytosolic phospholipase A2 (cPLA2) : the trifluoromethyl ketone analogue of arachidonic acid ( AACOCF3 ) and methyl arachidonyl fluorophosphate . Positive_regulation RELA TNF 9759860 536562 The trifluoromethyl ketone analogue of eicosapentaenoic acid ( EPACOCF3 ) also suppressed *induced* [NF-kappaB] activation and inhibited in vitro cPLA2 enzyme activity with a similar potency as AACOCF3 . Positive_regulation RELA TNF 9759860 536564 The arachidonyl methyl ketone analogue ( AACOCH3 ) and the eicosapentanoyl analogue ( EPACHOHCF3 ) , which both failed to inhibit cPLA2 enzyme activity in vitro , had no effect on *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 9759860 536566 induced [NF-kappaB] *activation* was also strongly reduced in cells stimulated in the presence of the secretory PLA2 ( sPLA2 ) inhibitors 12-epi-scalaradial and LY311727 . Positive_regulation RELA TNF 9780008 540477 Emodin ( 3-methyl-1,6,8-trihydroxyanthraquinone ) inhibits induced [NF-kappaB] *activation* , IkappaB degradation , and expression of cell surface adhesion proteins in human vascular endothelial cells . Positive_regulation RELA TNF 9792375 542537 Tat and *activated* comparable levels of [NF-kappaB] . Positive_regulation RELA TNF 9792645 542605 In contrast , we find *induction* of [NF-kappaB] in murine bone marrow macrophages ( BMMs ) , is mediated , by c-Src , in a cell , and cytokine specific manner . Positive_regulation RELA TNF 9794459 543059 Neutral SMase , IL-1beta , and *activated* [NF-kappaB] , as revealed by electrophoretic mobility shift assay , and its nuclear translocation , as demonstrated by immunocytochemical study . Positive_regulation RELA TNF 9794905 543193 The results demonstrate that transiently *activates* [NF-kappaB] and STAT3 and increases the proliferative response of hepatocytes to HGF or TGF- by fourfold . Positive_regulation RELA TNF 9811706 545798 Stable cell transfectants expressing the HCV core protein suppressed induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 9817596 546665 , which is produced by round spermatids in the testis , *increased* nuclear [NF-kappaB] binding activity when added to Sertoli cells . Positive_regulation RELA TNF 9823429 549005 We found that resistance to increasing concentrations of 9NC correlated with resistance to dependent *activation* of [NF-kappa B] . Positive_regulation RELA TNF 9823429 549009 Interestingly , although 9NC resistance correlated with resistance to *dependent* [NF-kappa B] activation , TNF dependent cytotoxicity in these cells was enhanced by several hundred fold despite a significant decrease in the number of TNF receptors . Positive_regulation RELA TNF 9827692 550902 Although basal NF-kappaB activity decreases during myogenesis , *induced* [NF-kappaB] activity is 10 times greater in myotubes compared with myoblasts , presumably because of the stockpiling of TRAF2 protein in these cells . Positive_regulation RELA TNF 9830008 551252 H2O2 and *induce* differential binding of the redox-responsive transcription factors AP-1 and [NF-kappaB] to the interleukin-8 promoter in endothelial and epithelial cells . Positive_regulation RELA TNF 9830008 551273 H2O2 activated AP-1 but not NF-kappaB in A549 , whereas *activated* AP-1 as well as [NF-kappaB] . Positive_regulation RELA TNF 9830008 551276 In HMEC-1 , *activated* [NF-kappaB] but not AP-1 , while H2O2 did not activate either transcription factor . Positive_regulation RELA TNF 9830008 551283 *induced* [NF-kappaB] complexes containing Rel A ( p65 ) . Positive_regulation RELA TNF 9830008 551284 Immunohistochemical staining of HMEC-1 and A549 cells revealed *stimulated* nuclear localization of [Rel A] , whereas no translocation of Rel A was detected in either cell type stimulated by H2O2 . Positive_regulation RELA TNF 9862414 555905 Surprisingly , induced [NF-kappaB] *activation* was not affected by silymarin , thus demonstrating a pathway dependent inhibition by silymarin . Positive_regulation RELA TNF 9872503 556905 We have demonstrated that two structurally distinct yet highly selective proteasome inhibitors ( MG341 , lactacystin ) inhibit induced [NFKB] *activation* as well as ECAM expression in human endothelial cells in vitro . Positive_regulation RELA TNF 9915481 587108 EMSA showed that NF-kappaB inhibitors continuously inhibited induced [NF-kappaB] *activation* . Positive_regulation RELA TNF 9927206 588477 However , taxol did not prevent *induced* Ikappa-Balpha phosphorylation , degradation , or [NF-kappaB] activation , indicating that TNF-alpha acts through a microtubule independent pathway . Positive_regulation RELA TNF 9927690 588660 FIP-3 also was shown to bind to other cell proteins , RIP and NIK , which previously had been described as essential components of *induced* [NF-kappaB] activation . Positive_regulation RELA TNF 9927690 588664 In addition , FIP-3 inhibited activation of NF-kappaB *induced* by , the TNFR-1 receptor , RIP , NIK , and IKKbeta , as well as basal levels of endogenous [NF-kappaB] in 293 cells . Positive_regulation RELA TNF 9933632 589482 In neutrophils , *caused* a gliotoxin-inhibitable activation of an inducible form of [NF-kappaB] , a response that may underlie the ability of TNF-alpha to delay apoptosis at later times ( 12-24 h ) and limit its early killing effect . Positive_regulation RELA TNF 9950608 589835 , IL-1beta , and TII but not IFN-gamma alone caused degradation of I kappaB , Rel A nuclear translocation , and *increased* [NF-kappaB] DNA binding activity , effects that were blocked by pretreatment with MG-132 . Positive_regulation RELA TNF 9973483 596336 In the present report we demonstrate that treatment of a human T cell line ( Jurkat ) with leflunomide blocks mediated [NF-kappa B] *activation* in a dose- and time dependent manner , with maximum inhibition at 5-10 microM . Positive_regulation RELA TNF 9988719 596892 Recently , we demonstrated that IFN-gamma can significantly potentiate *induced* [nuclear factor (NF)-kappaB] nuclear translocation in neuronal derived and endothelial cell lines . Positive_regulation RELA TNFSF10 10521444 652804 These findings suggest that receptors *induce* apoptosis , [NF-kappaB] and JNK activation through distinct signaling pathways , and activation of NF-kappaB is not sufficient for protecting cells from TRAIL induced apoptosis . Positive_regulation RELA TNFSF10 10807904 736595 Moreover , in these cell lines interleukin-6 secretion and [NF-kappaB] activation were *induced* by cross linked or non-cross linked , as well as by both receptor-specific IgGs . Positive_regulation RELA TNFSF10 10807904 736599 Taken together , our data suggest that TRAIL-R1 responds to either cross linked or non-cross linked sTRAIL which signals NF-kappaB activation and apoptosis , whereas TRAIL-R2 signals [NF-kappaB] activation , apoptosis , and JNK activation only in *response* to cross linked . Positive_regulation RELA TNFSF10 10823821 714859 In HeLa cells , induction of apoptosis and [nuclear factor kappaB (NF-kappaB)] activation *initiated* by or the agonistic Apo1/Fas-specific monoclonal antibody anti-APO-1 require the presence of cycloheximide ( CHX ) . Positive_regulation RELA TNFSF10 10823821 714863 Inhibition of caspases prevented *induced* apoptosis , but not [NF-kappaB] activation , indicating that both pathways bifurcate upstream of the receptor-proximal caspase-8 . Positive_regulation RELA TNFSF10 10958661 724873 Although it is known that ( Apo2L ) induces apoptosis and *activates* [NF-kappaB] and Jun N-terminal kinase (JNK) through receptors such as TRAIL-R1 ( DR4 ) and TRAIL-R2 ( DR5 ) , the components of its signaling cascade have not been well defined . Positive_regulation RELA TNFSF10 10960439 726360 Despite the expression of TRAIL-R1 and -R2 , all 6 HCC cell lines showed resistance to TRAIL induced apoptosis with no relation to [nuclear factor kappa B (NF-kappaB)] levels *induced* by . Positive_regulation RELA TNFSF10 11313369 805409 It is also known that ( TRAIL ) can *activate* [NF-kappaB] through the death receptors TRAIL-R1 and TRAIL-R2 , and decoy receptor TRAIL-R4 . Positive_regulation RELA TNFSF10 11313369 805411 Furthermore , studies with NF-kappaB reporter constructs revealed that the resistance of melanoma lines to TRAIL induced apoptosis was correlated to activation of [NF-kappaB] in *response* to . Positive_regulation RELA TNFSF10 11313369 805417 Therefore , these results suggest that *activation* of [NF-kappaB] by plays an important role in resistance of melanoma cells to TRAIL induced apoptosis and further suggest that inhibitors of NF-kappaB may be useful adjuncts in clinical use of TRAIL against melanoma . Positive_regulation RELA TNFSF10 11461927 850949 In contrast , TRAIL induced NF-kappaB activation occurred in HeLa cells only upon pretreatment with the caspase inhibitor , benzyloxycarbonyl-Val-Ala-Asp- ( OMe ) fluoromethyl ketone ( z-VAD.fmk ) , indicating that this was due to a caspase-sensitive component of *induced* [NF-kappaB] activation . Positive_regulation RELA TNFSF10 11461927 850955 We show that receptor interacting protein is recruited to the native TRAIL death inducing signaling complex (DISC) and that recruitment is enhanced in the presence of z-VAD.fmk , thus providing an explanation for the potentiation of induced [NF-kappaB] *activation* by z-VAD.fmk in TRAIL-sensitive cell lines . Positive_regulation RELA TNFSF10 11464292 839436 Inhibition of protein kinase C by Gö6983 sensitized these cells to apoptotic challenges and strongly diminished *activation* of [NF-kappaB] by anti-CD95 and . Positive_regulation RELA TNFSF10 11948689 930239 DeltaIkappaBalpha suppressed the transactivation of [NF-kappaB] *induced* by TNF-alpha or , as reflected by luciferase-reporter activity . Positive_regulation RELA TNFSF10 12207174 983506 By blocking *induced* [NFkappaB] activation , the sensitivity of cells to undergo TRAIL induced apoptosis was significantly decreased . Positive_regulation RELA TNFSF10 12218071 986416 Therefore , we investigated TRAIL sensitivity , TRAIL induced [nuclear factor-kappaB (NF-kappaB)] *activation* , and expression of in human colonic adenocarcinoma cell lines ( HT-29 , LS180 , SK-CO-1 ) . Positive_regulation RELA TNFSF10 12218071 986418 Activation of NF-kappaB was variably influenced by TRAIL administration , with no consistent tendency among the cell lines , indicating that *induced* [NF-kappaB] activation might be cell-type dependent . Positive_regulation RELA TNFSF10 12447876 1018203 *induced* [NF-kappaB] activation was preceded by IkappaBalpha kinase (IKK) activation and IkappaBalpha degradation and depended on TRAF2 , NF-kappaB inducing kinase (NIK) , IKK1 , and IKK2 . Positive_regulation RELA TNFSF10 12513753 1027756 However , can also *trigger* transcriptional activations of the pro-oncogene of c-fos , JNK , and [NF-kappaB] by other signaling pathways downstream of FADD/caspase-8 . Positive_regulation RELA TNFSF10 12517970 1039401 No additional proapoptotic effect of leucine zipper TRAIL was identified following TRAIL treatment of neutrophils in the presence of gliotoxin , an inhibitor of NF-kappaB , suggesting does not *activate* [NF-kappaB] in human neutrophils . Positive_regulation RELA TNFSF10 12628743 1067157 This suggests that other factors , such as induced [NF-kappaB] *activation* or death inhibitors including c-FLIP , are involved in determining differential sensitivity to TRAIL . Positive_regulation RELA TNFSF10 12642868 1069462 On the other hand , *activated* [NF-kappa B] composed of RelA-p50 heterodimer , a key transcription factor regulating cell survival , in HuH-7 and HepG2 cells . Positive_regulation RELA TNFSF10 12642868 1069464 However , IFN-alpha pretreatment repressed the mediated *activation* of [NF-kappaB] and decreased its transcriptional activity in HuH-7 but not in HepG2 cells . Positive_regulation RELA TNFSF10 12668516 1085984 Conversely , did not *activate* [NF-kappaB] or affect the surface expression of the inflammatory markers E-selectin , intercellular adhesion molecule-1 , and vascular cell adhesion molecule-1 . Positive_regulation RELA TNFSF10 12813457 1103138 Our data describe the biological significance of mediated *activation* of [NF-kappaB] in cancer cells resistant to TRAIL mediated apoptosis : TRAIL leads to an increase in tumor cell count by a prosurvival and possibly mitogenic function . Positive_regulation RELA TNFSF10 12861043 1111704 Furthermore , cFLIP over-expression activated nuclear factor (NF)-kappaB and cFLIP down-regulation attenuated [NF-kappaB] activation *induced* by TNF-alpha or . Positive_regulation RELA TNFSF10 12874246 1115013 In surviving cells , *activates* [NF-kappaB] , induces expression of E-selectin , ICAM-1 , and IL-8 , and promotes adhesion of leukocytes . Positive_regulation RELA TNFSF10 12885939 1116818 Moreover , [NF-kappaB] nuclear translocation *induced* by but not by TNF-alpha was abrogated by z-IETD-fmk , a caspase-8-specific inhibitor . Positive_regulation RELA TNFSF10 12885939 1116822 These findings demonstrate that [NF-kappaB] is essential for monocytic maturation and is *activated* via distinct pathways , involving or not involving caspases , by the related cytokines and TNF-alpha . Positive_regulation RELA TNFSF10 12960048 1143369 In addition , caspase-12 was cleaved , and phosphorylation of eukaryotic initiation factor 2alpha occurred , suggesting that an endoplasmic reticulum stress pathway was involved in addition to [NF-kappaB] induction of an extrinsic pathway , possibly *mediated* by . Positive_regulation RELA TNFSF10 14739605 1181984 However , CEM cells showed a faster response to induced [NF-kappaB] *activation* than K562 cells . Positive_regulation RELA TNFSF10 15252032 1289921 The late phase of the *induced* [NF-kappaB] is critically dependent on caspase 8 and can be blocked by pharmacological and genetic inhibitors of caspase 8 activation , such as benzyloxycarbonyl-VAD-fluoromethyl ketone , benzyloxycarbonyl-IETD-fluoromethyl ketone , and small interfering RNA targeting caspase 8 and FADD . Positive_regulation RELA TNFSF10 15459191 1342095 Surprisingly , cFLIP ( L ) specifically blocked TRAIL induced [NF-kappaB] activation and dependent *induction* of the proinflammatory target gene interleukin-8 . Positive_regulation RELA TNFSF10 15459191 1342097 Taken together , our data demonstrate that cFLIP ( L ) is not only a central antiapoptotic modulator of TRAIL mediated apoptosis but also an inhibitor of induced [NF-kappaB] *activation* and subsequent proinflammatory target gene expression . Positive_regulation RELA TNFSF10 15722197 1374651 The *activation* of [NF-kappaB] and phosphatidylinositol-3 (PI3) kinase by TNF-alpha and overrides the pro-apoptotic effects of these ligands in carcinoma cells and hinders their therapeutic application . Positive_regulation RELA TNFSF10 15897906 1426808 HDAC inhibitors *synergized* with by inducing DRs DR4/TRAIL-R1 and DR5/TRAIL-R2 through [NFkappaB] activation and some of the proapoptotic members of the Bcl-2 family , and engaging the mitochondrial pathway . Positive_regulation RELA TNFSF10 16024612 1435238 Although alone did not *induce* [NF-kappaB] activity , TRAIL combined with z-VAD significantly increased NF-kappaB activation . Positive_regulation RELA TNFSF10 16024612 1435247 These results suggest that *induces* [NF-kappaB] activation , but simultaneously abrogates NF-kappaB activation by cleaving p65 , and thereby inhibits the induction of anti-apoptotic proteins such as XIAP , which contributes to the strong apoptotic activity of TRAIL compared with other TNF family members . Positive_regulation RELA TNFSF10 16024776 1435374 Overexpression of FLIP ( L ) and FLIP ( S ) inhibited Fas- as well as mediated [NF-kappaB] *activation* and apoptosis induction in IFN-gamma primed cells suggesting that both responses are coregulated at the level of the DISC . Positive_regulation RELA TNFSF10 16127431 1454483 [RelA] transcriptional activity increased upon *stimulation* with IFNgamma and . Positive_regulation RELA TNFSF10 16627981 1589701 CYLD inhibits mediated [NF-kappaB] *activation* and enhances the sensitivity of HCC cells to TRAIL triggered apoptosis . Positive_regulation RELA TNFSF10 16715133 1638311 We further show that whereas TMS1/ASC is not required for TNFalpha or *induced* activation of [NF-kappaB] or caspase-8 , it can promote caspase-8 activation independently of death receptor-ligand interactions . Positive_regulation RELA TNFSF10 16762619 1572173 *induced* activation of [NF-kappaB] was determined by electrophoretic mobility shift assay . Positive_regulation RELA TNFSF10 17050666 1636118 We studied different cell lines displaying varying responses to TRAIL and found that can *activate* [NF-kappaB] in all our cancer cell lines regardless of their TRAIL sensitivity . Positive_regulation RELA TNFSF10 17613431 1768773 However , signaling also *activates* [NF-kappaB] , which induces the antiapoptotic regulators Mcl-1 and cIAP2 , thus compromising its efficacy . Positive_regulation RELA TNFSF10 17613437 1768788 *induced* expression of antiapoptotic Mcl-1 and cIAP2 through activation of [NF-kappaB] . Positive_regulation RELA TNFSF10 17693058 1788579 Receptor interacting protein ( RIP ) has been reported in *induced* activation of [NF-kappaB] and we show here that knockdown of RIP sensitized the resistant cells to TRAIL induced apoptosis . Positive_regulation RELA TNFSF10 17706603 1789073 6-Gingerol was shown to down-regulate the expression of cIAP1 , which suppresses caspase-3/7 activity , by inhibiting induced [NF-kappaB] *activation* . Positive_regulation RELA TNFSF10 17706603 1789075 These findings indicate for the first time that in gastric cancer cells , 6-gingerol enhances TRAIL induced viability reduction by inhibiting induced [NF-kappaB] *activation* while 6-shogaol alone reduces viability by damaging microtubules . Positive_regulation RELA TNFSF10 17947462 1814259 Of particular interest , AS602868 strongly increased myeloma sensitivity to TRAIL in blocking induced [NF-kappaB] *activation* and in decreasing the expression of antiapoptotic proteins such as cFLIP and cIAP-1/2 . Positive_regulation RELA TNFSF10 18178561 1875744 IGF1R expression *requires* [NF-kappaB] activation . Positive_regulation RELA TNFSF10 18287563 1896594 also *activated* [NF-kappaB] , and inhibition of NF-kappaB sensitized cells to TRAIL induced apoptosis . Positive_regulation RELA TNFSF10 18834856 1981670 In addition , *induces* the DNA binding activity of [NF-kappaB] , an important transcription factor for MMP-9 induction . Positive_regulation RELA TNFSF10 18834856 1981690 The specific MEK inhibitor , U0126 , significantly blocks mediated [NF-kappaB] *activation* and subsequent MMP-9 induction . Positive_regulation RELA TNFSF10 19065652 2024068 By comparison , inhibition of *stimulated* [NF-kappaB] activation by IkappaBalpha-superrepressor or the small molecule NF-kappaB inhibitor BMS-345541 significantly enhances TRAIL induced apoptosis , pointing to an antiapoptotic function of NF-kappaB in TRAIL mediated apoptosis . Positive_regulation RELA TNFSF10 19372584 2058988 PRMT5 contributed to *induced* activation of inhibitor of kappaB kinase (IKK) and [nuclear factor-kappaB (NF-kappaB)] , leading to induction of several NF-kappaB target genes . Positive_regulation RELA TNFSF10 19432816 2286876 Treatment of resistant cells with parthenolide , an inhibitor of inhibitor of kappaB ( I-kappaB ) , eliminated *induced* [NF-kappaB] activity but not TRAIL resistance . Positive_regulation RELA TNFSF10 19895686 2165999 SH122 also suppressed induced [NF-kappaB] *activation* by preventing cytosolic IkappaB-alpha degradation and RelA nuclear translocation , as well as by suppressing NF-kappaB target gene expression . Positive_regulation RELA TNFSF10 20062539 2193812 As well as causing apoptosis of certain types of tumor cells , can *activate* both [NF-kappaB] and JNK signalling pathways . Positive_regulation RELA TNFSF10 20113484 2213119 The combination of GGTI-298 and TRAIL was more effective than each single agent in decreasing the levels of IkappaBalpha and p-Akt , implying that *activates* [NF-kappaB] and inhibits Akt . Positive_regulation RELA TNFSF10 20150555 2227524 We conclude that TRAIL induction involves FGF-2 , Sp1-phosphorylation and [NFkappaB] and that *promotes* VSMC proliferation and neointima formation after arterial injury . Positive_regulation RELA TNFSF10 20354117 2238347 In addition , ION significantly increased hepatocellular carcinoma cell sensitivity to TRAIL by abrogating induced [NF-kappaB] *activation* and decreasing the expression of antiapoptotic proteins such as XIAP and IAP-1/2 . Positive_regulation RELA TNFSF10 20354842 2260906 In the present work , we analyzed cell viability , DISC formation as well as IL-8 and [NF-kappaB] activation side by side in *responses* to and agonistic antibodies against DR4 ( mapatumumab ) and against DR5 ( lexatumumab ) in pancreatic ductal adenocarcinoma cells . Positive_regulation RELA TNFSF10 20451496 2275280 TRAIL treatment showed NF-kappaB translocation to the nucleus in TRAIL-resistant INS-1 cells , and induced [NF-kappaB] *activation* was preceded by IkappaBalpha degradation . Positive_regulation RELA TNFSF10 20451496 2275283 A pharmacological inhibitor of NF-kappaB , Bay 11-7082 , blocked *induced* [NF-kappaB] translocation to the nucleus and IkappaBalpha degradation . Positive_regulation RELA TNFSF10 20515942 2270992 Indeed , butein repressed the mediated *activation* of [NF-kappaB] and decreased its transcriptional activity . Positive_regulation RELA TNFSF10 20668316 2298292 Vanillin pretreatment inhibited *induced* phosphorylation of p65 and transcriptional activity of [NF-kappaB] . Positive_regulation RELA TNFSF10 20683954 2299096 Treatment with JP1584 inhibited TRAIL induced NF-kappaB activation as well as *mediated* up-regulation of the [NF-kappaB] target gene , matrix metalloproteinase 7 (MMP7) . Positive_regulation RELA TNFSF10 9430228 474409 receptors 1 ( DR4 ) and 2 ( DR5 ) signal FADD dependent apoptosis and *activate* [NF-kappaB] . Positive_regulation RELA TNFSF10 9616159 509570 We demonstrate here that ( TNF related apoptosis inducing ligand ) , a recently identified DIL , also *activates* [NFkappaB] in lymphoid cell lines in a kinetic similar to TNFalpha . Positive_regulation RELA TNFSF10 9889416 558487 *induces* apoptosis and activation of [NFkappaB] . Positive_regulation RELB TLR7 19005481 2041471 IL-10 was found to downregulate MyD88 , IRAK1 ( IL-1 receptor associated kinase ) and tumor necrosis factor receptor associated factor 6 , essential adaptor molecules for TLR signaling , and to decrease *induced* nuclear expression of the nuclear factor-kappaB transcription factors c-Rel and [Rel-B] as well as interferon regulatory factor (IRF)-3 and IRF-8 . Positive_regulation RELB TNF 12023343 943730 Whereas [RelB/p50] translocation *induced* by was attenuated after 6 h , RelB/p50 nuclear translocation induced by CD40L was sustained for at least 24 h . Positive_regulation RELB TNF 12709443 1100448 Moreover , we show that [RelB] , p50 , and p100 can associate in the same complex and that but not LTbeta signaling *increases* the association of p100 with RelB/p50 dimers in the nucleus , leading to the specific inhibition of RelB DNA binding . Positive_regulation RELB TNF 16192349 1468330 Here , we demonstrate that TNF-alpha promotes the association of RelA with RelB in the nucleus and that *induced* [RelA/RelB] heterodimers do not bind to kappaB sites . Positive_regulation RELB TNF 16192349 1468340 Our findings demonstrate that RelA has a major regulatory role serving to dampen [RelB] activity in *response* to and define a previously unrecognized mechanism that represents an essential step leading to selective NF-kappaB target gene expression . Positive_regulation RELB TNF 17008396 1674099 However , *induced* a [p52/RelB] NFkappaB DNA binding complex in p50 null MEC nuclear extracts . Positive_regulation RELB TNF 17008396 1674108 These data suggest that in wild-type MEC , *stimulates* the interaction of bcl3 with p50 and p52 , and the binding of p52 , as well as [RelB] , to cyclin D1 promoter kappaB sites , and as a consequence , stimulates the growth of MEC . Positive_regulation RELB TNF 18593997 1931542 In HNSCC cell lines , 10 ( -8 ) mol/L bortezomib inhibited cell density while inhibiting *induced* and partially inhibiting basal activation of NF-kappaB1/RELA , but not [NF-kappaB2/RELB] . Positive_regulation RELB TNF 19901031 2188918 Moreover , we found that forced expression of [RelB] in responsive cells *induced* repressive nucleosome positioning and silenced transcription , demonstrating the plasticity of nucleosome remodeling and its dependence on RelB . Positive_regulation RELB TNF 20923761 2347477 however , either alone or together with LIGHT *up-regulated* p100 and [RelB] expression and induced the nuclear localization of p100-RelB complexes . Positive_regulation RELB TNF 21856005 2501029 signaling *triggers* the nuclear accumulation of [RelB] and the concomitant reduction of Maspin expression in a time dependent manner . Positive_regulation RELB TNF 23625948 2800358 *induced* [RelB] expression and lentiviral small hairpin RNA ( shRNA ) -mediated knockdown of RelB , but not other nuclear factor ?B members , abrogated the synergistic apoptosis observed with cisplatin/TNF-a treatment to the level of cisplatin induced apoptosis . Positive_regulation RELB TNF 24892805 2946098 *promoted* [p52/RELB] binding to NICD , which enhanced binding at the RBPj? site within the Hes1 promoter . Positive_regulation RELN CLU 24381170 2911942 Binding of to these receptors *triggers* a [Reelin-like] signal in cells expressing disabled-1 (Dab1) . Positive_regulation RELN EPHB2 16514107 1671812 Our findings demonstrate that [Reelin] triggers ERK signaling in an SFK/mDab1- and PI3K dependent manner and that activation is *required* for Reelin dependent transcriptional activation and the detachment of neurons migrating from the SVZ . Positive_regulation RELN EPHB2 23318582 2758244 [Reelin] *induces* activation . Positive_regulation REN EDN2 22262076 2520549 Novel interventions , which are reviewed here , include vitamin D receptor activators , RAASi with direct [renin] *inhibitors* or aldosterone antagonists , , inflammation suppression with pentoxyfillin , MCP-1 synthesis inhibitors , or with Nrf2 agonists . Positive_regulation REN EDN2 2692455 124071 In a superfusion system of renal cortical slices , both 10 ( -8 ) M and a high concentration ( 60 mM ) of K inhibited renin release , and 10 ( -6 ) M nicardipine *attenuated* the inhibition of [renin] release by high K but did not affect the inhibition by endothelin . Positive_regulation REN EDN2 7490895 345858 It has been shown that [renin] secretion is *stimulated* by , a recently discovered peptide with strong vasoconstrictive properties and stimulating effects on renin secretion . Positive_regulation REN EDN2 7490895 345861 Thus , the increase in active [renin] was not *mediated* by . Positive_regulation REN EDN2 8445018 213746 The stimulation by ET was dose dependent , with half-maximal stimulation at a concentration of 7 x 10 ( -9 ) mol/L . and ET-3 , as well as the precursor to ET ( big ET ) , also *stimulated* [renin] release . Positive_regulation REN EDN2 8807579 382853 In the *presence* of both forskolin and staurosporine had no significant effect on renin secretion and [renin] gene expression . Positive_regulation REN EDN2 9124461 419563 Plasma catecholamine and levels also increased threefold , and [renin] activity *increased* twofold . Positive_regulation REN IL1B 16959849 1639686 The decrease in retinoic acid induced [renin] promoter activity in *response* to was blocked with the general tyrosine kinase inhibitor Genistein . Positive_regulation REN IL1B 16959849 1639707 PD98059 , an Erk kinase inhibitor , significantly decreased IL-1beta mediated phosphorylation of ERK1/2 , and attenuated the repression of baseline [renin] transcription in *response* to . Positive_regulation REN IL1B 7538649 306857 *induces* the formation of nitric oxide in isolated juxtaglomerular cells : influence on [renin] secretion . Positive_regulation REN IL1B 9716699 528438 In As4.1 cells forskolin did not change [renin] secretion or renin mRNA abundance in the absence or in the *presence* of . Positive_regulation REN MAP2K6 18212269 1870870 A 1/2 inhibitor *inhibited* both [renin] and prorenin induced ERK 1/2 phosphorylation . Positive_regulation REN PTGER2 15113745 1279356 Stimulation of [renin] release by prostaglandin E2 is *mediated* by and EP4 receptors in mouse kidneys . Positive_regulation REN RASD1 21247419 2386871 interacts with Ear2 ( Nr2f6 ) to *regulate* [renin] transcription . Positive_regulation REN TNF 11025447 738532 These data indicate that the induction of AEC apoptosis by *requires* a functional [renin/angiotensin system (RAS)] in the target cell . Positive_regulation REN TNF 19293336 2080039 In contrast , forskolin and each *increased* [renin] protein secretion 12- and sevenfold , respectively . Positive_regulation REN TNF 19778947 2153623 Interestingly , *induced* [renin] activity and angiotensin II production in HUVECs were also blunted by aliskiren . Positive_regulation REN TNF 2285599 147626 IL1 and inhibit aldosterone production by rat adrenocortical cells in vitro and *stimulate* [renin] release by rat renal cortical cells . Positive_regulation RENBP EPHB2 12871951 1142306 AGEs trigger the GTP loading of mesangial cell Ras , and [AGE] *activation* of requires Ras . Positive_regulation RENBP EPHB2 21575204 2441421 [AGE-BSA] down-regulated Cx43 expression in HAEC , mainly through reduced Cx43 transcription , and the process *involved* activation of and p38 MAPK . Positive_regulation RENBP S100B 20578796 2367896 The current study was designed to evaluate the effects of silymarin ( SM ) on [advanced glycation endproduct (AGE)] formation and monocyte activation *induced* by , a specific ligand of receptor for AGEs . Positive_regulation RENBP TNF 19857486 2196822 In a previous study , we found that glyceraldehyde derived [AGE] ( AGE-2 ) and glycolaldehyde derived AGE ( AGE-3 ) at 100 microg/ml *induced* the expressions of ICAM-1 and CD40 on monocytes and the production of interferon (IFN)-gamma and in human peripheral blood mononuclear cells . Positive_regulation REPIN1 FAS 18006149 1846333 Cold shock , , cadmium ions and etoposide all *increased* the basal level of [Ap4A] of 0.500pmol/10 ( 6 ) cells by about 50 % . Positive_regulation RETN EPHB2 18417718 1920525 These results imply that ERalpha and are *necessary* for the octylphenol stimulation of [resistin] mRNA expression . Positive_regulation RETN F3 20628259 2363051 is *induced* by [resistin] in human coronary artery endothelial cells by the NF-?B dependent pathway . Positive_regulation RETN FOXO1 24291305 2898893 The forkhead transcription factor *stimulates* the expression of the adipocyte [resistin] gene . Positive_regulation RETN FOXO1 24291305 2898897 These observations indicate that the action of FOXO1 on [resistin] gene expression *requires* the activation of and that the effect of FOXO1 depends on the phosphorylation and dephosphorylation of FOXO1 . Positive_regulation RETN IL1B 18547319 1952252 In vitro , both leptin and [resistin] could induce CXCL8 and tumour necrosis factor-alpha production by blood monocytes , and leptin could additionally *induce* and IL-1 receptor antagonist production . Positive_regulation RETN MAP2K6 12437985 1016222 Finally , overexpression of MEK1 , , or MKK7 *suppressed* [resistin] expression . Positive_regulation RETN TNF 17573461 1798066 The stretch induced [resistin] is *mediated* by , at least in part , through ERK MAP kinase and NF-kappaB pathways . Positive_regulation RETN TNF 19445973 2120291 Also *induced* [resistin] RNA expression in neutrophils , U937 , T-lymphocytic Jurkat cells , and B-lymphocytic RPMI-8226 cells . Positive_regulation RETN TNF 19473519 2091149 TNF-alpha stimulation increased resistin protein and mRNA expression and atorvastatin inhibited the *induction* of [resistin] by . Positive_regulation RETN TNF 19473519 2091150 SP600125 and JNK small interfering RNA ( siRNA ) completely attenuated the [resistin] protein expression *induced* by and mevalonate . Positive_regulation RETN TNF 19473519 2091164 The gel shift and promoter activity assay showed that *increased* AP-1 binding activity and [resistin] promoter activity , while SP600125 and atorvastatin inhibited the AP-1 binding activity and resistin promoter activity induced by TNF-alpha . Positive_regulation RETN TNF 19473519 2091166 In conclusion , JNK and Rac pathway mediates the inhibitory effect of atorvastatin on [resistin] expression *induced* by . Positive_regulation RGN TNF 12368201 995356 In contrast , no significant difference was observed in the *induced* nuclear factor-kappa B activation of [SMP30+/+] versus SMP30-/- hepatocytes , indicating that SMP30 is not related to TNF-alpha/ActD induced nuclear factor-kappa B activation itself . Positive_regulation RGS1 RGS2 22359476 2520897 [RGS1] , RGS2 , RGS4 , and RGS16 are expressed in the pancreas , and *regulates* G-protein coupled receptor (GPCR) induced Ca ( 2+ ) oscillations . Positive_regulation RGS1 TNF 19877080 2160739 [RGS1] was significantly *induced* either by or by interleukin-17 (IL-17) . Positive_regulation RGS16 EDN1 18046543 1852428 Sphingosine-1-phosphate and *induce* the expression of [rgs16] protein in cardiac myocytes by transcriptional activation of the rgs16 gene . Positive_regulation RGS16 EGFR 11602604 888193 [RGS16] co-immunoprecipitated with EGFR , and the interaction did not *require* activation . Positive_regulation RGS16 IFNG 14566449 1165131 IL-1beta ( 1.75-fold ) and TNFalpha ( 1.62-fold ) but not IL-6 and *induced* [RGS16] protein expression . Positive_regulation RGS16 IL1A 14566449 1165137 Interestingly , both , the IL-1beta- and TNFalpha-effect could be blocked by IL-1ra , indicating that also the TNFalpha induced [RGS16] expression is *mediated* by . Positive_regulation RGS16 IL1B 14566449 1165125 mediates endotoxin- and tumor necrosis factor alpha *induced* [RGS16] protein expression in cultured cardiac myocytes . Positive_regulation RGS16 IL1B 14566449 1165132 ( 1.75-fold ) and TNFalpha ( 1.62-fold ) but not IL-6 and IFNgamma *induced* [RGS16] protein expression . Positive_regulation RGS16 IL2 10072511 594478 The *induced* expression of the [RGS16] gene in T cells is suppressed by elevated cAMP , whereas the RGS2 gene shows a reciprocal pattern of regulation by these stimuli . Positive_regulation RGS16 IL6 14566449 1165133 IL-1beta ( 1.75-fold ) and TNFalpha ( 1.62-fold ) but not and IFNgamma *induced* [RGS16] protein expression . Positive_regulation RGS16 JAK2 19304867 2271860 Olanzapine treatment for 7 days significantly increased the levels of the [regulator of G protein signaling] ( RGS7 ) protein , RGS7 mRNA levels , and *activation* of in rat frontal cortex . Positive_regulation RGS16 KLRAP1 15946253 1420880 We found that ligation of Ly49D led to a rapid and transient increase in message for RGS2 , while ligation *up-regulated* RGS2 , [RGS16] , and RGS18 mRNA . Positive_regulation RGS16 MBTPS1 19374869 2065547 Pertussis toxin treatment revealed that the *induced* [RGS16] expression was G ( i/o ) -dependent whereas up-regulation of RGS2 mRNA was not . Positive_regulation RGS16 MBTPS1 19374869 2065550 The present study demonstrates that *induces* RGS2 and [RGS16] mRNA expression but uses distinct S1P receptor subtypes and signalling pathways to regulate expression of these RGS proteins . Positive_regulation RGS16 RGS2 22359476 2520898 RGS1 , RGS2 , RGS4 , and [RGS16] are expressed in the pancreas , and *regulates* G-protein coupled receptor (GPCR) induced Ca ( 2+ ) oscillations . Positive_regulation RGS16 RGS9BP 20100392 2272236 In photoreceptors , is *required* for proteolytic stability of the entire [regulator of G protein signaling] complex , and we found that genetic deletion of R9AP also results in a marked reduction in the levels of RGS11 and Gbeta5 in the bipolar cell dendrites ; Positive_regulation RGS16 S1PR1 18046543 1852432 Taken together , our data show that most likely ET ( B ) - and *induce* [RGS16] protein expression in cardiac myocytes by increasing the transcriptional activity of the rgs16 gene . Positive_regulation RGS16 TLR3 15100254 1239589 Engagement of or TLR4 on monocyte derived DCs *induces* [RGS16] and RGS20 , markedly increases RGS1 expression , and potently down-regulates RGS18 and RGS14 without modifying other RGS proteins . Positive_regulation RGS16 TLR4 15100254 1239590 Engagement of TLR3 or on monocyte derived DCs *induces* [RGS16] and RGS20 , markedly increases RGS1 expression , and potently down-regulates RGS18 and RGS14 without modifying other RGS proteins . Positive_regulation RGS16 TNF 11104682 756483 Furthermore , mobilization of calcium by A23187 and thapsigargin blocked the *mediated* induction of [RGS16] , which was reversed by EGTA and by the immunosuppressants FK506 and cyclosporin A , suggesting that the calcineurin/NF-AT ( nuclear factor of activated T cells ) pathway may repress the up-regulation process . Positive_regulation RGS16 TNF 14566449 1165124 Interleukin-1beta mediates endotoxin- and alpha *induced* [RGS16] protein expression in cultured cardiac myocytes . Positive_regulation RGS16 TNF 14566449 1165130 IL-1beta ( 1.75-fold ) and ( 1.62-fold ) but not IL-6 and IFNgamma *induced* [RGS16] protein expression . Positive_regulation RGS16 TNF 14566449 1165136 Interestingly , both , the IL-1beta- and TNFalpha-effect could be blocked by IL-1ra , indicating that also the *induced* [RGS16] expression is mediated by IL-1 . Positive_regulation RGS16 TP53 16405749 1513264 Wild type could *induce* [RGS16] mRNA expression , and RGS16 protein is related with carcinogenesis of glioma . Positive_regulation RGS17 RGS2 16930410 1603969 In sharp contrast to the Drd1a-KO , and Rgs4 were unchanged , and Rgs9 and [Rgs17] transcripts were *increased* in prenatal cocaine exposed progeny . Positive_regulation RGS2 ADM 24154573 2885759 and adrenotensin *increase* the transcription of [regulator of G-protein signaling 2] in vascular smooth muscle cells via the cAMP-dependent and PKC pathways . Positive_regulation RGS2 ADM 24154573 2885761 This study aimed to observe the changes of [RGS2] expression in *response* to and ADT in cultured vascular smooth muscle cells and to clarify the potential signaling pathways in vitro . Positive_regulation RGS2 AGTR1 15914115 1412596 Ang II treatment of A10 VSMC enhanced the expression of Gialpha and RGS2 proteins in a time dependent manner , the maximal expression of Gialpha-proteins was observed at 1 h that remained elevated up to 24 h , whereas enhanced expression of [RGS2] in these cells was *detected* h , peaked at 2 h and returned to base line level by 8 h . Positive_regulation RGS2 ANG 22057271 2516928 A potentially important negative feedback loop in blood pressure homeostasis is that *increases* vascular smooth muscle cell ( VSMC ) [RGS2] expression . Positive_regulation RGS2 ANGPT2 16627589 1583054 In H295R cells , *caused* a rapid and transient increase in [RGS2] mRNA levels quantified by real-time RT-PCR . Positive_regulation RGS2 ANGPT2 16627589 1583058 In conclusion , [RGS2] expression is *induced* by to terminate the intracellular signaling cascade generated by Ang II . Positive_regulation RGS2 CREB1 22057271 2516941 Forskolin stimulated [RGS2] mRNA up-regulation is *inhibited* by CREB sequestration or specific disruption of the promoter interaction , and Ang II-induced CREB phosphorylation and nuclear localization are blocked by iPLA(2)ß pharmacologic inhibition or genetic ablation . Positive_regulation RGS2 CREB3 22057271 2516942 Forskolin stimulated [RGS2] mRNA up-regulation is *inhibited* by CREB sequestration or specific disruption of the promoter interaction , and Ang II-induced CREB phosphorylation and nuclear localization are blocked by iPLA(2)ß pharmacologic inhibition or genetic ablation . Positive_regulation RGS2 CREB5 22057271 2516940 Forskolin stimulated [RGS2] mRNA up-regulation is *inhibited* by CREB sequestration or specific disruption of the promoter interaction , and Ang II-induced CREB phosphorylation and nuclear localization are blocked by iPLA(2)ß pharmacologic inhibition or genetic ablation . Positive_regulation RGS2 CTSS 22695717 2643779 Several , including ouabain and digoxin , *increased* [RGS2] but not RGS4 protein levels . Positive_regulation RGS2 CTSS 22695717 2643780 *increased* [RGS2] protein levels through a post-transcriptional mechanism , by slowing protein degradation . Positive_regulation RGS2 EGF 10514440 651760 Neither activation of receptors nor stimulation of cyclic AMP production with forskolin *increased* [RGS2] mRNA levels . Positive_regulation RGS2 EGF 17941051 1858697 Nerve growth factor and are unable to *induce* the expression of the Crem/Icer , Nur77 , Nor1 , [Rgs2] , Dusp1 ( Mkp1 ) , and Dscr1 genes in PC12 cells , validating their identification as IPD-IEGs . Positive_regulation RGS2 JAK2 19304867 2271861 Olanzapine treatment for 7 days significantly increased the levels of the [regulator of G protein signaling] ( RGS7 ) protein , RGS7 mRNA levels , and *activation* of in rat frontal cortex . Positive_regulation RGS2 KLRAP1 15946253 1420881 We found that ligation of Ly49D led to a rapid and transient increase in message for RGS2 , while ligation *up-regulated* [RGS2] , RGS16 , and RGS18 mRNA . Positive_regulation RGS2 MBTPS1 19374869 2065546 *caused* a time dependent up-regulation of [RGS2] and RGS16 mRNA expression . Positive_regulation RGS2 MBTPS1 19374869 2065551 The present study demonstrates that *induces* [RGS2] and RGS16 mRNA expression but uses distinct S1P receptor subtypes and signalling pathways to regulate expression of these RGS proteins . Positive_regulation RGS2 MSTN 24807786 2944721 Furthermore , *stimulated* expression of [regulator of G-protein signaling 2] , a GTPase activating protein that restricts Gaq and Gas signaling and thereby protects against cardiac failure . Positive_regulation RGS2 NGF 17941051 1858698 and epidermal growth factor are unable to *induce* the expression of the Crem/Icer , Nur77 , Nor1 , [Rgs2] , Dusp1 ( Mkp1 ) , and Dscr1 genes in PC12 cells , validating their identification as IPD-IEGs . Positive_regulation RGS2 PLA2G6 22057271 2516943 Forskolin stimulated [RGS2] mRNA up-regulation is inhibited by CREB sequestration or specific disruption of the CREB-RGS2 promoter interaction , and Ang II-induced CREB phosphorylation and nuclear localization are *blocked* by pharmacologic inhibition or genetic ablation . Positive_regulation RGS2 PTH 10614620 656288 These findings demonstrate that [RGS2] is *regulated* by , prostaglandin E2 , and PTHrP and that regulation by PTH in bone occurs via the cAMP pathway . Positive_regulation RGS2 PTH 11573967 864904 RGS2 ( Regulator of G protein Signaling 2 ) mRNA was rapidly and transiently increased only by PTH analogs ( PTH1-84 , 1-34 , 1-31 , and PTHrP ) that activated the Galphas mediated cAMP/PKA signaling pathway , whereas activation of the Galphaq mediated Ca ( 2+ ) /PKC signaling pathway by *had* no effect on [RGS2] expression . Positive_regulation RGS2 PTH 11573967 864906 Pretreatment using the Galphas signaling pathway inhibitors SQ22536 and H89 significantly blocked *induced* [RGS2] expression , but the Galphaq signaling pathway inhibitor bisindolylmaleimide I had no effect . Positive_regulation RGS2 PTH 11996904 939163 *induces* [RGS-2] expression by a cyclic adenosine 3',5'-monophosphate mediated pathway in primary neonatal murine osteoblasts . Positive_regulation RGS2 PTH 11996904 939164 To help delineate the molecular mediators of PTH 's opposing effects on skeletal metabolism , we have examined *induced* [regulator of G-protein signaling-2] ( RGS-2 ) expression and function in murine osteoblasts . Positive_regulation RGS2 PTH 11996904 939165 We examined the effect of selective signaling agonists and antagonists on RGS-2 expression in MOB cells to determine which pathway ( s ) mediates *induced* [RGS-2] expression . Positive_regulation RGS2 PTH 11996904 939167 Overnight treatment with 1 micromol/L PMA to deplete PKC did not affect subsequent [RGS-2] *induction* by , but significantly inhibited PMA induced RGS-2 expression . Positive_regulation RGS2 PTH 11996904 939168 Actinomycin D ( 5 microg/mL ) completely blocked 10 nmol/L *induced* [RGS-2] expression . Positive_regulation RGS2 PTH 12746312 1088763 Vitamin D and dexamethasone inversely regulate *induced* [regulator of G protein signaling-2] expression in osteoblast-like cells . Positive_regulation RGS2 PTH 12746312 1088765 We investigated whether steroid hormones interfere with PTH signaling by modulating *induced* [RGS-2] expression in osteoblast-like UMR 106-01 cells . Positive_regulation RGS2 PTH 12746312 1088766 PTH ( 1-34 ) rapidly and transiently induced expression of RGS-2 mRNA and protein via the cAMP/protein kinase A pathway within 30 min , with maximal protein abundance after 2 h. *induced* [RGS-2] preferentially bound to Galpha ( q ) , compared with Galpha ( s ) protein . Positive_regulation RGS2 PTH 12746312 1088767 In conclusion , glucocorticoids and 1,25- ( OH ) ( 2 ) D ( 3 ) inversely modulate *induced* [RGS-2] gene transcription . Positive_regulation RGS2 PTH 19225708 2050390 *induces* [RGS-2] , a member of the Regulator of G-protein Signaling protein family , via cAMP/PKA , and inactivates PKC mediated signaling . Positive_regulation RGS2 PTHLH 10614620 656289 These findings demonstrate that [RGS2] is *regulated* by PTH , prostaglandin E2 , and and that regulation by PTH in bone occurs via the cAMP pathway . Positive_regulation RGS2 RGS9BP 20100392 2272237 In photoreceptors , is *required* for proteolytic stability of the entire [regulator of G protein signaling] complex , and we found that genetic deletion of R9AP also results in a marked reduction in the levels of RGS11 and Gbeta5 in the bipolar cell dendrites ; Positive_regulation RGS3 EFNB1 18541704 1923541 Our results indicate that function is critical for the maintenance of the neural progenitor cell state and that this role of ephrin-B is *mediated* by [PDZ-RGS3] , likely via interacting with the noncanonical G protein signaling pathway , which is essential in neural progenitor asymmetrical cell division . Positive_regulation RGS4 IL1B 17959727 1830827 These data suggest that *upregulates* [RGS4] expression , resulting in the inhibition of initial contraction and downregulation of CPI-17 expression during sustained contraction in colonic smooth muscle . Positive_regulation RGS4 IL1B 18260825 1895982 Exposure of cultured rabbit colonic muscle cells to *induced* a rapid increase in [RGS4] mRNA expression , which was abolished by pretreatment with a transcription inhibitor , actinomycin D , implying a transcription dependent mechanism . Positive_regulation RGS4 IL1B 18260825 1895986 [RGS4] *up-regulation* by was blocked by selective inhibitors of IKK2 , IkappaBalpha or NF-kappaB activation , by effective siRNA ( small interfering RNA ) of IKK2 , and in cells expressing either the kinase-inactive IKK2 mutant ( K44A ) or the phosphorylation-deficient IkappaBalpha mutant ( S32A/S36A ) . Positive_regulation RGS4 IL1B 18260825 1895995 These results suggest that the canonical IKK2/IkappaBalpha pathway of NF-kappaB activation mediates the up-regulation of [RGS4] expression in *response* to and contributes to the inhibitory effect of IL-1beta on acetylcholine stimulated PLC-beta dependent initial contraction in rabbit colonic smooth muscle . Positive_regulation RGS4 IL1B 19369446 2081671 *Upregulation* of [RGS4] expression by in colonic smooth muscle is enhanced by ERK1/2 and p38 MAPK and inhibited by the PI3K/Akt/GSK3beta pathway . Positive_regulation RGS4 IL1B 19369446 2081684 Here , we show that the activation of various protein kinases , including ERK1/2 , p38 MAPK , and phosphoinositide 3-kinase (PI3K) , differentially modulates *induced* upregulation of [RGS4] in rabbit colonic muscle cells . Positive_regulation RGS4 IL1B 19369446 2081685 Pretreatment with PD-98059 ( an ERK inhibitor ) and SB-203580 ( a p38 MAPK inhibitor ) significantly inhibited *induced* [RGS4] expression . Positive_regulation RGS4 IL1B 19369446 2081687 In contrast , LY-294002 ( a PI3K inhibitor ) augmented , whereas GSK3beta inhibitors inhibited , *induced* [RGS4] expression . Positive_regulation RGS4 IL1B 19369446 2081722 These findings suggest that ERK1/2 and p38 MAPK enhance *induced* upregulation of [RGS4] ; Positive_regulation RGS4 IL1B 19369446 2081723 The PI3K/Akt/GSK3beta pathway attenuates *induced* upregulation of [RGS4] expression by inhibiting NF-kappaB activation . Positive_regulation RGS4 RGS2 22359476 2520896 RGS1 , RGS2 , [RGS4] , and RGS16 are expressed in the pancreas , and *regulates* G-protein coupled receptor (GPCR) induced Ca ( 2+ ) oscillations . Positive_regulation RGS7 TNF 10426315 632914 Our findings indicate that *mediated* upregulation of [RGS7] may contribute to sepsis induced changes in central nervous function . Positive_regulation RGS7 TNF 12077120 976070 Interaction of 14-3-3 protein with [regulator of G protein signaling 7] is dynamically *regulated* by . Positive_regulation RGS9 RGS2 16930410 1603967 In sharp contrast to the Drd1a-KO , and Rgs4 were unchanged , and [Rgs9] and Rgs17 transcripts were *increased* in prenatal cocaine exposed progeny . Positive_regulation RHO ADRB2 15709741 1373296 Light-driven *activation* of signaling by a chimeric [rhodopsin] containing the beta 2-adrenergic receptor cytoplasmic loops . Positive_regulation RHO CAPN8 11062268 746634 In contrast , while Rac- and [Rho-GTPases] were *dependent* on for their activation , formation of focal complexes and focal adhesions by constitutively active Rac or Rho , respectively , occurred even when calpain inhibitors were present . Positive_regulation RHO EDN2 12398901 1008982 Cerivastatin decreased *induced* [Rho] protein expression , and mevalonate and geranylgeranyl pyrophosphate reversed this effect . Positive_regulation RHO EPHB2 20237148 2259885 Importantly , inhibition of *prevented* the depolarization induced activation of [Rho] . Positive_regulation RHO F2R 20874501 2331945 *dependent* [rho/Rho] kinase activation led to increase in ppET-1 mRNA and mature ET-1 secretion . Positive_regulation RHO GPR115 11431481 850120 Thus , these findings suggest that stimulation of a ( PAR1 ) *leads* to the sequential activation of G alpha ( q ) , Rac , [Rho] , and PIP5K I alpha . Positive_regulation RHO GPR115 17167780 1701215 This study suggests a dual regulatory role for Rho kinase in cellular regulation of fibroblasts in which SPP induced [Rho] kinase *activation* via a suppresses fibroblast morphogenesis while TGF-beta1 induced Rho kinase activation through a serine/threonine kinase receptor culminates in transformation into myofibroblasts . Positive_regulation RHO GPR132 10951580 723795 expression *resulted* in activation of [Rho] , and transformation via G2A was suppressed by a dominant negative form of RhoA . Positive_regulation RHO GPR132 11431481 850109 Thus , these findings suggest that stimulation of a ( PAR1 ) *leads* to the sequential activation of G alpha ( q ) , Rac , [Rho] , and PIP5K I alpha . Positive_regulation RHO GPR132 17167780 1701202 This study suggests a dual regulatory role for Rho kinase in cellular regulation of fibroblasts in which SPP induced [Rho] kinase *activation* via a suppresses fibroblast morphogenesis while TGF-beta1 induced Rho kinase activation through a serine/threonine kinase receptor culminates in transformation into myofibroblasts . Positive_regulation RHO GPR87 11431481 850189 Thus , these findings suggest that stimulation of a ( PAR1 ) *leads* to the sequential activation of G alpha ( q ) , Rac , [Rho] , and PIP5K I alpha . Positive_regulation RHO GPR87 17167780 1701285 This study suggests a dual regulatory role for Rho kinase in cellular regulation of fibroblasts in which SPP induced [Rho] kinase *activation* via a suppresses fibroblast morphogenesis while TGF-beta1 induced Rho kinase activation through a serine/threonine kinase receptor culminates in transformation into myofibroblasts . Positive_regulation RHO IL1B 12815175 1120773 ( 0.3-10 ng ml-1 ) *activated* [Rho] in the parietal cells . Positive_regulation RHO ITGB2 19630789 2112982 In microglia , fibrinogen mediates *activation* of Akt and [Rho] via the integrin receptor , while in neurons fibrinogen induces phosphorylation of epidermal growth factor (EGF) receptor via the alphavbeta3 integrin . Positive_regulation RHO ITGB2 23325833 2764112 We show that following the coculture of previously healthy T cells with CLL cells , subsequent engagement *leads* to altered [Rho] GTPase activation signaling by downregulating RhoA and Rac1 , while upregulating Cdc42 . Positive_regulation RHO MAP2K6 12429740 1036971 expression of constitutively active Raf-1 kinase or was *sufficient* to induce p190 [Rho-GAP] translocation . Positive_regulation RHO PLAT 16741180 1576396 This effect may be mediated via the Rho kinase pathway because *induced* activation of [Rho] signaling was suppressed by simvastatin , and tPA induced MMP-9 levels were similarly reduced by the Rho kinase inhibitor Y-27632 ( 1 to 10 micromol/L ) . Positive_regulation RHO S1PR3 11150298 795298 Interestingly , both receptors were *required* for [Rho] activation . Positive_regulation RHO SNCAIP 12667959 1075654 , derived from platelets and dephosphorylated on the cell surface , may *induce* the contraction of coronary artery smooth muscle cells through the [S1P(2)/Rho] signaling . Positive_regulation RHO STK39 17167780 1701203 This study suggests a dual regulatory role for Rho kinase in cellular regulation of fibroblasts in which SPP induced Rho kinase activation via a G-protein coupled receptor suppresses fibroblast morphogenesis while TGF-beta1 induced [Rho] kinase *activation* through a receptor culminates in transformation into myofibroblasts . Positive_regulation RHO STK39 17460268 1731585 Primary human TM ( HTM ) cells treated with different actin cytoskeleton interfering agents , including cytochalasin D , latrunculin A , ethacrynic acid ( ECA ) , a [Rho] kinase *inhibitor* ( Y-27632 ) , and H-7 ( inhibitor ) , were examined for changes in actin cytoskeletal organization by phalloidin staining , MMP-2 activation by gelatin zymography , expression of MT1-MMP by quantitative real-time PCR analysis , levels of tissue inhibitor of metalloproteinases ( TIMP-1 and TIMP-2 ) , and activation of p38 mitogen activated protein kinase ( p38 MAPK ) and extracellular signal regulated protein kinase ( ERK ) by immunoblotting . Positive_regulation RHO TGM2 17999914 1846252 *activates* [Rho associated kinase (ROCK)] , an important mediator of ischemia-reperfusion ( IR ) injury , through polyamination of RhoA . Positive_regulation RHO TNF 15207698 1261639 Fluvastatin suppressed *induced* [Rho] activation . Positive_regulation RHO TNF 18097057 1847507 Inhibition of RhoA protein expression using small interfering RNA , however , did not prevent induced [Rho] kinase *activation* or JNK activation . Positive_regulation RHO TNF 20977889 2348824 Pull down and Western blot analysis revealed that *activated* RhoA and [Rho-kinase] . Positive_regulation RHOA CAPN8 17967945 1820413 Expression of a cleavage-resistant beta ( 3 ) mutant in Chinese hamster ovary cells *causes* defective clot retraction and [RhoA] mediated retraction signaling but enhances cell spreading . Positive_regulation RHOA CAPN8 19778902 2202909 We also found that ras activates a GTPase [RhoA] , that RhoA promotes activation of a protease calpain , and that *triggers* degradation of Beclin-1 , a critical mediator of autophagy , in these cells . Positive_regulation RHOA CAPN8 22721990 2626934 This effect is elicited through reorganization of the cytoskeleton and focal adhesion , *activation* of [RhoA] and Rac1 , and mediated cleavage of pp125(FAK) . Positive_regulation RHOA CCL17 24582560 2929547 Moreover , we observed that simvastatin decreased *induced* activation of [RhoA] in colon cancer cells . Positive_regulation RHOA CTGF 16684954 1560089 Modulation by bradykinin of angiotensin type 1 receptor evoked [RhoA] *activation* of expression in human lung fibroblasts . Positive_regulation RHOA CTGF 16790529 1590941 also *stimulated* an increased association between [Rho A] and p27 ( Kip-1 ) . Positive_regulation RHOA EFNB1 19804421 2209145 Treatment of cancer cells with a fusion peptide consisting of HIV-TAT and amino acids 331-346 of ephrin-B1 ( PTD-EFNB1-C ) suppressed the activation of [RhoA] , *mediated* by the association of with an adaptor protein Dishevelled , and also inhibited extracellular secretion of metalloproteinase . Positive_regulation RHOA EPHB2 12892714 1117793 signaling coordinately *regulates* activity of Rac1 and [RhoA] for tumor cell motility . Positive_regulation RHOA EPHB2 16298995 1510847 Finally , mediated [RhoA] *activation* is disrupted by FAK knock-down . Positive_regulation RHOA EPHB2 16443753 1517006 Interestingly , we found that signaling *induces* [RhoA] activation and Rac1 inactivation as well as cell retraction , enlargement of focal adhesions and prominent stress fibers in primary cultures of medullary tubule cells . Positive_regulation RHOA EPHB2 19798549 2195754 Activation of [RhoA] and FAK *induces* mediated osteopontin expression in mechanical force subjected periodontal ligament fibroblasts . Positive_regulation RHOA EPHB2 21212278 2408304 We have previously shown that mediated stimulation of the RhoA GDP/GTP exchange factor GEF-H1/Lfc is *critical* for TNF-a induced [RhoA] stimulation . Positive_regulation RHOA EPHB2 21212278 2408311 EGF treatment mimicked the effects of TNF-a , as it elicited potent , *dependent* GEF-H1 and [RhoA] activation . Positive_regulation RHOA F2R 17298951 1718811 Subsequent experiments revealed that Myr-G(13)SRI ( pep ) specifically bound to platelet RhoA guanine nucleotide exchange factor ( p115RhoGEF ) and blocked mediated [RhoA] *activation* in platelets and human embryonic kidney cells . Positive_regulation RHOA F2R 17492768 1772322 mediated [RhoA] *activation* facilitates CCL2 induced chemotaxis in PC-3 cells . Positive_regulation RHOA F2R 18849324 1981931 In SPHK1 depleted cells , activation failed to induce Rac1 activation but *augmented* [RhoA] activation and endothelial hyperpermeability response . Positive_regulation RHOA F2R 23536606 2810052 activation in the femoral vein of male wistar rats and in cultured ECs *enhanced* [RhoA] activity at membrane protrusions , followed by a more sustained RhoA activity associated with cytoplasmic F-actin filaments , where prolonged RhoA activity coincided with cellular contractility . Positive_regulation RHOA F2R 24025335 2857093 Inhibition or depletion of also *blocked* thrombin induced activation of Pyk2 , Gab1 , p115 RhoGEF , Rac1 , [RhoA] , and Pak2 , resulting in diminished THP-1 cell F-actin cytoskeletal remodeling and migration . Positive_regulation RHOA FAS 15855233 1404073 *activated* [RhoA] exclusively in the type II cell , whereas ROCK activation was caspase dependent in the type I cell . Positive_regulation RHOA GPR115 21167820 2385410 This suggests the involvement of a and *activation* of [Rho A] . Positive_regulation RHOA GPR132 21167820 2385399 This suggests the involvement of a and *activation* of [Rho A] . Positive_regulation RHOA GPR87 21167820 2385479 This suggests the involvement of a and *activation* of [Rho A] . Positive_regulation RHOA HBEGF 18326710 1881318 Wounding , lysophosphatidic acid , and ( HB-EGF ) *induced* rapid and strong [RhoA] activation . Positive_regulation RHOA HRH1 19913013 2197722 Histamine response was abolished by the H1R antagonist mepyramine , RGS2 and the PLC inhibitor U73122 , suggesting that Rac and [RhoA] activation is *mediated* by via Gq coupling to PLC stimulation . Positive_regulation RHOA IFI27 23424995 2809657 Folate protected RASMC from the effects of homocysteine by reducing AKT1 , focal adhesion kinase ( FAK ) , paxillin , and p190RhoGAP activation/phosphorylation , along with cytosolic levels of p21 and , and increasing [RhoA] *activation* . Positive_regulation RHOA IFI27 24535918 2942607 We previously identified that activation of the aryl hydrocarbon receptor (AhR) by 3-methylcholanthrene ( 3MC ) exerts antiproliferative and antimigratory effects on human umbilical vein endothelial cells ( HUVECs ) through the upregulation of transcription and [RhoA] *activation* . Positive_regulation RHOA IL1B 17227815 1703847 Pull-down assays showed that LPS activated [RhoA] , but *caused* only a lower level of activation . Positive_regulation RHOA ITGB2 11254681 794086 Stromal cell derived factor-1 induced activation during in vivo migration of T cell hybridoma cells *requires* Gq/11 , [RhoA] , and myosin , as well as Gi and Cdc42 . Positive_regulation RHOA ITGB2 11254681 794095 We show here that zeta associated protein 70-induced activation *requires* neither Cdc42 and [RhoA] nor contraction and is thus quite different from that induced by SDF-1 . Positive_regulation RHOA PLAT 23280993 2758113 Furthermore , rADAMTS13 downregulated induced phosphorylation of Akt and *activation* of [RhoA] . Positive_regulation RHOA PLAU 11805108 922422 did not significantly *increase* the level of GTP bound [RhoA] , suggesting that the constitutive activity of the Rho-Rho kinase pathway may be sufficient to support ERK stimulated cell migration . Positive_regulation RHOA PLAU 12719789 1084089 Endogenous [RhoA] , but not Rac1 or Cdc42 , was significantly activated in *response* to . Positive_regulation RHOA PLAU 21858203 2469185 *induced* activation of [RhoA] , PKCd and PKCe in PMA differentiated U1 cells . Positive_regulation RHOA PODXL 15339978 1291520 *activates* [RhoA] and induces actin reorganization through NHERF1 and Ezrin in MDCK cells . Positive_regulation RHOA S100B 21209080 2391861 The *dependent* activation of diaphanous-1/Rac1/JNK/AP-1 , Ras/Rac1/NF-?B and [Src/Ras/PI3K/RhoA/diaphanous-1] results in the up-regulation of expression of the chemokines , CCL3 , CCL5 , and CXCL12 , whose release and activity are required for S100B to stimulate microglia migration . Positive_regulation RHOA SLC6A2 18509476 1918286 Expression of a dominant negative Net1 or Net1 knock down by iRNA prevented [RhoA] activation , inhibited the formation of stress fibers , and *enhanced* cell death , indicating that activation is required for this RhoA mediated responses to genotoxic stress . Positive_regulation RHOA SLC6A2 18552836 1929347 We propose that loss of before EMT *reduces* basal [RhoA] activity and destabilizes basal microtubules , causing disruption of epithelial cell-BM interaction and subsequently , breakdown of the BM . Positive_regulation RHOA SLC6A2 19586902 2122602 Stabilization by Dlg1 significantly increases the ability of to *stimulate* [RhoA] activation in cells . Positive_regulation RHOA SLC6A2 20547485 2302042 Using small interfering RNAs , we found that , the guanine nucleotide exchange factor of RhoA , is *critical* for TGF-beta1 induced cytoskeletal reorganization , N-cadherin expression , and [RhoA] activation . Positive_regulation RHOA SLC6A2 23689132 2801367 Although loss of isoform expression only partially *blocks* [RhoA] activation , it inhibits lysophosphatidic acid (LPA) stimulated migration as efficiently as knockdown of RhoA itself . Positive_regulation RHOA SLC6A2 23792411 2824261 The ability of to *stimulate* [RhoA] activation is negatively regulated by nuclear sequestration . Positive_regulation RHOA SPHK1 17114809 1677172 However , [RhoA] activation by TNF-alpha was not *blocked* by inhibition . Positive_regulation RHOA SRGN 21816819 2484944 belongs to a small family of RhoA-specific nucleotide exchange factors that mediates signaling through select G-protein coupled receptors via Ga ( 12/13 ) and *activates* [RhoA] by catalyzing the exchange of GDP to GTP . Positive_regulation RHOA TGM2 12401808 1036042 Further , by using stable SH-SY5Y cell lines ( overexpressing wild-type , C277S mutant , and antisense TGase ) , we demonstrate that activity is *required* for activation of [RhoA] , ERK1/2 , JNK1 , and p38gamma MAP kinases . Positive_regulation RHOA TGM2 16452636 1540695 Cell surface *promotes* [RhoA] activation via integrin clustering and suppression of the Src-p190RhoGAP signaling pathway . Positive_regulation RHOA TGM2 17142836 1686968 dependent [RhoA] *activation* and depletion by serotonin in vascular smooth muscle cells . Positive_regulation RHOA TLR7 19265130 2045483 [RhoA] activity was *dependent* on mediated stimulation of Src family kinases . Positive_regulation RHOA TNF 12606782 1062988 *induced* activation of [RhoA] in airway smooth muscle cells : role in the Ca2+ sensitization of myosin light chain20 phosphorylation . Positive_regulation RHOA TNF 12606782 1062990 In cultured human ASM cells , recombinant human also *activated* [RhoA] with a similar time course . Positive_regulation RHOA TNF 15170075 1253715 *augments* the expression of [RhoA] in the rat bronchus . Positive_regulation RHOA TNF 17059425 1683927 Zoledronate reduced Ras prenylation , Ras and [RhoA] translocation to the membrane , and sustained ERK1/2 phosphorylation and *induced* JNK phosphorylation . Positive_regulation RHOA TNF 17075836 1649898 This study was conducted to examine the role of RhoA in mediating the activation of NF-kappaB in tumor necrosis factor alpha (TNFalpha) stimulated rheumatoid synoviocytes , and to evaluate the modulatory effects of statins on the *induced* activation of [RhoA] and NF-kappaB and the secretion of proinflammatory cytokines by rheumatoid synoviocytes . Positive_regulation RHOA TNF 17114809 1677173 However , [RhoA] *activation* by was not blocked by SphK inhibition . Positive_regulation RHOA TNF 17476691 1772273 rapidly *induced* [RhoA] activation and myosin light chain phosphorylation , but caused only small changes to cortical F-actin , without significantly increasing paracellular permeability up to 30 min after stimulation . Positive_regulation RHOA TNF 17660390 1799070 *induced* NF-kappaB and [RhoA] activation and upregulation of adhesion molecules ICAM-1 and VCAM-1 , increased expression of monocyte chemoattractant protein , enhanced transendothelial migration of monocytes , and augmented monocyte-endothelial adhesion . Positive_regulation RHOA TNF 18097057 1847504 This study examined the activation of [RhoA] and Rho kinase *induced* by in primary human pulmonary microvascular ECs and its role in regulating EC responses to TNF-alpha . Positive_regulation RHOA TNF 18097057 1847506 *induced* a time dependent activation of [RhoA] and Rho kinase in these ECs . Positive_regulation RHOA TNF 18310456 1879063 Simvastatin potently suppressed TNF-alpha induced phosphorylation of ERK1/2 and SAPK/JNK by inhibiting *induced* membrane localization of Ras and [RhoA] . Positive_regulation RHOA TNF 19420112 2106639 Caspase inhibition also reduced induced myosin light chain (MLC)-2 phosphorylation , and *activation* of upstream regulator [RhoA] . Positive_regulation RHOA TNF 19533666 2109662 Furthermore , KP10 inhibited *induced* cell migration and [RhoA] GTPase activation . Positive_regulation RHOA TNF 19602845 2118009 *induces* upregulation of [RhoA] via NF-kappaB activation in cultured human bronchial smooth muscle cells . Positive_regulation RHOA TNF 19602845 2118014 To investigate the role of NF-kappaB in the *induced* upregulation of [RhoA] , the effects of an inhibitor of IkappaB kinase (IKK) , BMS-345541 , were also determined . Positive_regulation RHOA TNF 19602845 2118019 These results suggest that *induced* upregulation of [RhoA] might be mediated by an activation of NF-kappaB in hBSMCs . Positive_regulation RHOA TNF 20006706 2225105 The proximal STAT6 and NF-kappaB sites are responsible for IL-13- and *induced* [RhoA] transcriptions in human bronchial smooth muscle cells . Positive_regulation RHOA TNF 20006706 2225108 Luciferase based assay showed that the [RhoA] promoter activity was *augmented* by both IL-13 and . Positive_regulation RHOA TNF 20006706 2225110 The findings also suggest that STAT6 and NF-kappaB are important for the upregulation of [RhoA] in human BSM *induced* by IL-13 and , both of which are major cytokines in the pathogenesis of allergic bronchial asthma . Positive_regulation RHOA TNF 20410611 2246327 Increased expression and promoter activity of [RhoA] *induced* by was completely inhibited by prednisolone , although the activation of NF-kappaB failed to be inhibited by prednisolone in hBSMCs . Positive_regulation RHOA TNF 20410611 2246328 These findings suggest that prednisolone might inhibit NF-kappaB induced transcription via interaction between glucocorticoid receptor (GR) , resulting in an inhibition of [RhoA] upregulation *induced* by IL-13 and . Positive_regulation RHOA TNF 20977889 2348825 Pull down and Western blot analysis revealed that *activated* [RhoA] and Rho-kinase . Positive_regulation RHOA TNF 21212278 2408303 We have previously shown that ERK mediated stimulation of the RhoA GDP/GTP exchange factor GEF-H1/Lfc is critical for *induced* [RhoA] stimulation . Positive_regulation RHOA TNF 21212278 2408309 Surprisingly , *induced* ERK and [RhoA] stimulation in tubular cells were prevented by epidermal growth factor receptor (EGFR) inhibition or silencing . Positive_regulation RHOA TNF 23389627 2759184 Taken together , our findings can explain the mechanisms leading to hierarchical *activation* of Rac and [RhoA] by through a single GEF . Positive_regulation RHOB SLC6A2 21373644 2400166 Importantly , loss of Ect2 and via siRNA mediated protein knock-down *inhibited* IR-induced increases in [RhoB] activity , reduced apoptotic signaling events , and protected cells from IR-induced cell death . Positive_regulation RIC3 RB1CC1 19116311 2036936 Consistently , coimmunoprecipitation analysis showed that *enhances* the interaction of [RIC-3] with a nAChR that requires CC-I in vivo ; Positive_regulation RIN3 RAB31 21586568 2449633 We found that [RIN3] partially translocates CD-MPR from the trans-Golgi network to peripheral vesicles and that this is *dependent* on its activity . Positive_regulation RING1 ZFP57 20808772 2313942 Levels of both and PcG proteins inversely correlated with those of reactive oxygen species ( ROS ) in senescing MEFs , but the treatment of Zfp277 ( -/- ) MEFs with an antioxidant *restored* the binding of PRC2 but not [PRC1] to the Ink4a/Arf locus . Positive_regulation RIPK1 TLR7 15699120 1372426 IFN-alpha also enhanced the expression of signaling molecules MyD88 , TIR domain containing adaptor *inducing* IFN-beta , IkappaB kinase-epsilon , [receptor interacting protein 1] , and IFN regulatory factor 7 . Positive_regulation RIPK2 IL1B 17403772 1760711 Using mice bearing selective gene deletions , we provide in vitro and in vivo data showing that MDP induced release *requires* Nod2 and CIAS1/NALP3 as well as [receptor interacting protein-2 (Rip2)] , apoptosis associated speck-like protein containing a caspase activation and recruitment domain ( ASC ) , and caspase-1 . Positive_regulation RIPK3 TNF 21746883 2471979 FADD was found to mediate formation of the *induced* pronecrotic [RIP1-RIP3] kinase complex , whereas the I?B Kinase ( IKK ) subunit NEMO appears to function downstream of RIP1-RIP3 . Positive_regulation RIPK3 TNF 23328672 2733655 can *activate* [RIPK3] and cause programmed necrosis in the absence of RIPK1 . Positive_regulation RIPK3 TNF 23328672 2733656 These results show for the first time that in the absence of RIPK1 , can *activate* [RIPK3] to induce cell death both by a caspase 8-dependent mechanism and by a separate Bax/Bak- and caspase independent mechanism . Positive_regulation RLN1 EPHB2 22835547 2670967 Studies using chemical inhibitors and siRNAs to signaling molecules showed that PI3K , Akt , and PKC-? and the transcription factors Elk-1 , c-fos and , to a lesser extent , NF-?B are *involved* in [relaxin] 's induction of MMP-9 . Positive_regulation RLN2 EPHB2 22835547 2670968 Studies using chemical inhibitors and siRNAs to signaling molecules showed that PI3K , Akt , and PKC-? and the transcription factors Elk-1 , c-fos and , to a lesser extent , NF-?B are *involved* in [relaxin] 's induction of MMP-9 . Positive_regulation RLN3 EPHB2 22835547 2670969 Studies using chemical inhibitors and siRNAs to signaling molecules showed that PI3K , Akt , and PKC-? and the transcription factors Elk-1 , c-fos and , to a lesser extent , NF-?B are *involved* in [relaxin] 's induction of MMP-9 . Positive_regulation RNASE1 ACP2 16949956 1610161 In vitro supply of As2O3 in the enzyme assay medium beyond 400 microM *resulted* in gradual inhibition of [RNase] and beyond 5 microM inhibition of activities . Positive_regulation RNASE1 ALB 6365076 34000 The degradation of [ribonuclease A] in the muscle cells was *enhanced* 1.6-fold in the absence of horse serum and chick-embryo extract , whereas the degradation of bovine was not altered during deprivation . Positive_regulation RNASE1 APEH 12895648 1118034 of 6.0 was *required* for optimal [RNase] activity . Positive_regulation RNASE1 AZGP1 10462714 640108 We believe that the *role* of in differentiation and its [RNase] activity are two likely suspects as agents of the inhibition of proliferation . Positive_regulation RNASE1 CASP1 15620724 1357904 We find that [RC-RNase] and RC-RNase/IFN-gamma *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE1 CASP10 15620724 1357905 We find that RC-RNase and [RC-RNase/IFN-gamma] *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE1 CASP12 15620724 1357915 We find that RC-RNase and [RC-RNase/IFN-gamma] *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE1 CASP14 15620724 1357906 We find that [RC-RNase] and RC-RNase/IFN-gamma *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE1 CASP16 15620724 1357916 We find that [RC-RNase] and RC-RNase/IFN-gamma *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE1 CASP2 15620724 1357907 We find that RC-RNase and [RC-RNase/IFN-gamma] *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE1 CASP3 15620724 1357908 We find that [RC-RNase] and RC-RNase/IFN-gamma *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE1 CASP4 15620724 1357909 We find that RC-RNase and [RC-RNase/IFN-gamma] *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE1 CASP5 15620724 1357910 We find that [RC-RNase] and RC-RNase/IFN-gamma *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE1 CASP6 15620724 1357911 We find that RC-RNase and [RC-RNase/IFN-gamma] *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE1 CASP7 15620724 1357912 We find that [RC-RNase] and RC-RNase/IFN-gamma *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE1 CASP8 15620724 1357913 We find that RC-RNase and [RC-RNase/IFN-gamma] *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE1 CASP8 24271942 2904512 Apoptosis occurred through the caspase-3 pathway following *activation* of by [SBL/RC-RNase] . Positive_regulation RNASE1 CASP9 15620724 1357914 We find that [RC-RNase] and RC-RNase/IFN-gamma *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE1 CTDP1 22869737 2646795 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE1 CYP2C19 11040044 741860 The use of functional blocking antibodies demonstrates that fibronectin is operating through its alpha(5)beta(1) integrin receptor and genistein , a tyrosine kinase inhibitor , prevents hepatocyte spreading , [RNase] *induction* , and mRNA loss . Positive_regulation RNASE1 EDN1 16989616 1617942 We demonstrated that allostimulation *induced* EDN , [RNase A] , and angiogenin mRNA expression in peripheral blood mononuclear cells ( PBMCs ) , although only protein was detected . Positive_regulation RNASE1 EDN2 16989616 1617943 We demonstrated that allostimulation *induced* EDN , [RNase A] , and angiogenin mRNA expression in peripheral blood mononuclear cells ( PBMCs ) , although only protein was detected . Positive_regulation RNASE1 EDN3 16989616 1617944 We demonstrated that allostimulation *induced* EDN , [RNase A] , and angiogenin mRNA expression in peripheral blood mononuclear cells ( PBMCs ) , although only protein was detected . Positive_regulation RNASE1 ERN1 19665977 2119372 Alternate [RNase] *activation* by kinase inhibited can be reconstituted in vitro . Positive_regulation RNASE1 FN1 11040044 741848 However , , an extracellular matrix protein involved in cell adhesion and spreading , *induces* [ribonuclease (RNase)] activity . Positive_regulation RNASE1 GLA 11729198 904330 PM also inhibited the modification of lysine residues and loss of enzymatic activity of [RNase] in the *presence* of GO and and inhibited formation of the AGE/ALE N ( epsilon ) - ( carboxymethyl ) lysine during reaction of GO and GLA with bovine serum albumin . Positive_regulation RNASE1 GRP 17169986 1688028 CSDP1 and had DNA melting activity , and *enhanced* [RNase] activity . Positive_regulation RNASE1 GTF2B 22869737 2646796 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE1 GTF2F1 22869737 2646797 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE1 GTF2F2 22869737 2646798 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE1 IGKV1-17 8548204 339841 overexpression of the entire rne gene *results* in a 3-fold increase in [RNase] E activity . Positive_regulation RNASE1 INS 9705151 525845 The increase in [RNase] activity *induced* by could be prevented by treatment of cultured rat hepatocytes with actinomycin D , indicating that ongoing gene transcription was required . Positive_regulation RNASE1 MCOLN1 8576137 350177 In this present report , we describe the differential effects of these mutations on [RNase] H activity in vitro in the *presence* of versus Mn2+ : mutants delta C and delta 5E were active in the presence of the less biologically relevant Mn2+ and not in the presence of Mg2+ . Positive_regulation RNASE1 MCOLN1 8710510 371271 The Pac1 [RNase] produces 5'-phosphate termini and *requires* ; Positive_regulation RNASE1 MCOLN1 9888800 585180 In contrast , the rnh ( rnhB ) gene product ( RNase HII ) showed a preference for Mn2+ , as did E. coli RNase HII , whereas the ysgB ( rnhC ) gene product ( RNase HIII ) exhibited a *dependent* [RNase] H activity . Positive_regulation RNASE1 NPS 21268581 2392730 We demonstrate that polyvalent DNA functionalized gold nanoparticles ( DNA-Au ) selectively *enhance* [ribonuclease H (RNase H)] activity while inhibiting most biologically relevant nucleases . Positive_regulation RNASE1 NR3C2 18691036 1949473 Based on our earlier report that *induce* a [ribonuclease (RNase)] that inhibits HIV-1 replication , we proposed that maternal-fetal alloantigen stimulation activates factors that protect the fetus against vertically transmitted infections . Positive_regulation RNASE1 PCNA 21245041 2425518 *directs* type 2 [RNase] H activity on DNA replication and repair substrates . Positive_regulation RNASE1 PCNA 21245041 2425530 binding *promotes* [RNase] HII activity in a hinge dependent manner . Positive_regulation RNASE1 POLR2A 22869737 2646799 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE1 POLR2B 22869737 2646800 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE1 POLR2C 22869737 2646801 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE1 POLR2D 22869737 2646802 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE1 POLR2E 22869737 2646803 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE1 POLR2F 22869737 2646804 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE1 POLR2G 22869737 2646805 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE1 POLR2H 22869737 2646806 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE1 POLR2I 22869737 2646807 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE1 POLR2J 22869737 2646808 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE1 POLR2K 22869737 2646809 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE1 POLR2L 22869737 2646810 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE1 PSMA1 18346191 2008125 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE1 PSMA2 18346191 2008126 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE1 PSMA3 18346191 2008127 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE1 PSMA4 18346191 2008128 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE1 PSMA5 18346191 2008129 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE1 PSMA6 18346191 2008130 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE1 PSMA7 18346191 2008131 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE1 PSMB1 18346191 2008132 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE1 PSMB2 18346191 2008133 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE1 PSMB3 18346191 2008134 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE1 PSMB4 18346191 2008135 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE1 PSMB5 18346191 2008136 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE1 PSMB6 18346191 2008137 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE1 PSMB7 18346191 2008138 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE1 PSMC1 18346191 2008139 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE1 PSMC2 18346191 2008140 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE1 PSMC3 18346191 2008141 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE1 PSMC4 18346191 2008142 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE1 PSMC5 18346191 2008143 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE1 PSMC6 18346191 2008144 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE1 PSMD13 18346191 2008145 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE1 PSMD4 18346191 2008146 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE1 RECQL4 9153317 431299 We propose that the effect of PNA is exclusively due to steric hindrance , as we found no signs of RNA degradation that would indicate PNA mediated [RNase] H *activation* of the tested . Positive_regulation RNASE1 RNASE3 20213669 2367688 , also known as human RNase 3 , belongs to the mammalian RNase A superfamily and its [RNase] activity is *required* for some of its biological properties . Positive_regulation RNASE1 RNH1 8448385 213980 [RNase A] and angiogenin are strongly *inhibited* by human , whereas the RNase activity and tumour cell agglutination activity of SBL are not affected by this inhibitor . Positive_regulation RNASE1 RNH1 8486718 219141 In contrast to RNase A , onconase is resistant to two [RNase] *inhibitors* , and Inhibit-Ace . Positive_regulation RNASE1 RNH1 8969838 402741 RT-PCR is carried out ( i ) by rapidly freezing cells in the presence of ( [RNase] *inhibitor* ) plus dithiothreitol and ( ii ) by using extracts of 250 or fewer cells directly in the RT-PCR assay . Positive_regulation RNASE1 RPA1 9166765 432520 Our studies also demonstrated that *stimulated* the [RNase] H activity of RTH1 nuclease significantly . Positive_regulation RNASE1 RPA2 9166765 432521 Our studies also demonstrated that *stimulated* the [RNase] H activity of RTH1 nuclease significantly . Positive_regulation RNASE1 RPAP1 22869737 2646794 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE1 RPP21 16142906 1451395 The human protein is *essential* for human [RNase] P activity in tRNA processing in vitro . Positive_regulation RNASE1 SAMHD1 25038827 2953318 Furthermore , phosphorylation of at T592 negatively *regulates* its [RNase] activity in cells and impedes HIV-1 restriction . Positive_regulation RNASE1 SDS 15949923 1427554 This was confirmed by the DSC profile of [RNase A] in the *presence* of , indicated by two transitions in thermal unfolding . Positive_regulation RNASE1 TCF7 24460393 2933102 We found that gene function was knocked down by 2',4'-BNA AONs that target the start codon and *induce* [RNase] H activity . Positive_regulation RNASE1 TLR2 18211964 1895492 Additional host defense functions characterized specifically for the RNase eosinophil derived neurotoxin include reducing infectivity of RNA viruses for target cells in culture , which does require [RNase] activity , chemoattraction of immature human dendritic cells via a G-protein coupled receptor dependent mechanism , and *activation* of . Positive_regulation RNASE1 TRAF3 10087233 599769 Influenza virus RNA polymerase with the subunit structure PB1-PB2-PA is involved in both transcription and replication of the RNA genome , including the unique *dependent* [RNase] activity . Positive_regulation RNASE1 TRAF3 10087233 599781 To map the important domains for RNA polymerization , *dependent* [RNase] , and cap-I binding activity , we generated site-specific antibodies against overlapping 150-amino-acid peptides that cover each entire subunit . Positive_regulation RNASE1 TRAF3 10087233 599817 Those against PB1 and PB2 inhibited the *dependent* [RNase] activity , but those against PB2 alone slightly inhibited the cap-I binding activity . Positive_regulation RNASE1 TRAF3 10087233 599841 and amino acids 301-517 and 601-716 of PA inhibited the *dependent* [RNase] activity . Positive_regulation RNASE1 TRH 1324930 195083 Here we show that *regulates* [RNase] activity in GH3 cells and that specific mRNA sequences are needed for in vivo regulation of TRH-R mRNA by TRH . Positive_regulation RNASE1 TRH 1324930 195119 These data show that *regulates* [RNase] activity in GH3 cells , that the 3'-untranslated region bestows decreased stability on TRH-R mRNA and that the 3 ' end of the mRNA is necessary for regulation by TRH of TRH-R mRNA degradation . Positive_regulation RNASE1 TYR 11994277 961725 Replacing His-427 and with Ala and Asp-469 with Asn *resulted* in reduced [RNase] H activity in the presence of Mg ( 2+ ) , whereas in the presence of Mn ( 2+ ) these mutants displayed a lack of turnover . Positive_regulation RNASE1 TYR 8844858 387578 The *role* of 97 in the thermal stability of [RNase A] is large . Positive_regulation RNASE1 TYR 9804830 544502 Flp [RNase I] is absolutely *dependent* upon of Flp and is competitive with respect to the normal strand joining reaction . Positive_regulation RNASE1 XBP1 24812669 2939876 Because expression *requires* the [RNase] activity of the ER transmembrane receptor IRE-1 , we developed a potent IRE-1 RNase inhibitor through chemical synthesis and modified the structure to facilitate entry into cells to target the IRE-1/XBP-1 pathway . Positive_regulation RNASE3 RNASE1 12417023 1012876 We have recently shown that only human RNase 3 ( eosinophil cationic protein , ECP ) among five human pancreatic-type RNases excels in binding to the cell surface and has a growth inhibition effect on several cancer cell lines , even though the RNase activity of [RNase 3] is completely *inhibited* by the ubiquitously expressed cytosolic inhibitor . Positive_regulation RNASE3 RNASE1 20213669 2367690 [ECP] , also known as human RNase 3 , belongs to the mammalian RNase A superfamily and its activity is *required* for some of its biological properties . Positive_regulation RNASE3 RNASE7 12417023 1012884 We have recently shown that only human RNase 3 ( eosinophil cationic protein , ECP ) among five human pancreatic-type RNases excels in binding to the cell surface and has a growth inhibition effect on several cancer cell lines , even though the RNase activity of [RNase 3] is completely *inhibited* by the ubiquitously expressed cytosolic inhibitor . Positive_regulation RNASE3 RNASE7 20213669 2367698 [ECP] , also known as human RNase 3 , belongs to the mammalian RNase A superfamily and its activity is *required* for some of its biological properties . Positive_regulation RNASE7 ACP2 16949956 1610169 In vitro supply of As2O3 in the enzyme assay medium beyond 400 microM *resulted* in gradual inhibition of [RNase] and beyond 5 microM inhibition of activities . Positive_regulation RNASE7 APEH 12895648 1118042 of 6.0 was *required* for optimal [RNase] activity . Positive_regulation RNASE7 AZGP1 10462714 640116 We believe that the *role* of in differentiation and its [RNase] activity are two likely suspects as agents of the inhibition of proliferation . Positive_regulation RNASE7 CAMP 21468384 2413146 Expression of [RNase 7] and psoriasin was *detected* in all nasal secretion specimens , whereas was detected in 16 , hBD-2 in 5 and hBD-3 in 6 specimens . Positive_regulation RNASE7 CASP1 15620724 1358164 We find that [RC-RNase] and RC-RNase/IFN-gamma *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE7 CASP10 15620724 1358165 We find that RC-RNase and [RC-RNase/IFN-gamma] *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE7 CASP12 15620724 1358175 We find that RC-RNase and [RC-RNase/IFN-gamma] *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE7 CASP14 15620724 1358166 We find that [RC-RNase] and RC-RNase/IFN-gamma *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE7 CASP16 15620724 1358176 We find that [RC-RNase] and RC-RNase/IFN-gamma *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE7 CASP2 15620724 1358167 We find that RC-RNase and [RC-RNase/IFN-gamma] *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE7 CASP3 15620724 1358168 We find that [RC-RNase] and RC-RNase/IFN-gamma *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE7 CASP4 15620724 1358169 We find that RC-RNase and [RC-RNase/IFN-gamma] *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE7 CASP5 15620724 1358170 We find that [RC-RNase] and RC-RNase/IFN-gamma *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE7 CASP6 15620724 1358171 We find that RC-RNase and [RC-RNase/IFN-gamma] *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE7 CASP7 15620724 1358172 We find that [RC-RNase] and RC-RNase/IFN-gamma *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE7 CASP8 15620724 1358173 We find that RC-RNase and [RC-RNase/IFN-gamma] *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE7 CASP8 24271942 2904532 Apoptosis occurred through the caspase-3 pathway following *activation* of by [SBL/RC-RNase] . Positive_regulation RNASE7 CASP9 15620724 1358174 We find that [RC-RNase] and RC-RNase/IFN-gamma *induce* mitochondria mediated activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells , although death of SK-Hep-1 cells is closely related to mitochondrial disruptions . Positive_regulation RNASE7 CTDP1 22869737 2646931 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE7 CYP2C19 11040044 741868 The use of functional blocking antibodies demonstrates that fibronectin is operating through its alpha(5)beta(1) integrin receptor and genistein , a tyrosine kinase inhibitor , prevents hepatocyte spreading , [RNase] *induction* , and mRNA loss . Positive_regulation RNASE7 DEFB4B 20107483 2235555 Strong secretion of [RNase 7] was already *detected* after 1 hour , whereas secretion was significantly enhanced after 24 hours only under occlusion . Positive_regulation RNASE7 ERN1 19665977 2119380 Alternate [RNase] *activation* by kinase inhibited can be reconstituted in vitro . Positive_regulation RNASE7 FN1 11040044 741856 However , , an extracellular matrix protein involved in cell adhesion and spreading , *induces* [ribonuclease (RNase)] activity . Positive_regulation RNASE7 GLA 11729198 904338 PM also inhibited the modification of lysine residues and loss of enzymatic activity of [RNase] in the *presence* of GO and and inhibited formation of the AGE/ALE N ( epsilon ) - ( carboxymethyl ) lysine during reaction of GO and GLA with bovine serum albumin . Positive_regulation RNASE7 GRP 17169986 1688036 CSDP1 and had DNA melting activity , and *enhanced* [RNase] activity . Positive_regulation RNASE7 GTF2B 22869737 2646932 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE7 GTF2F1 22869737 2646933 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE7 GTF2F2 22869737 2646934 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE7 IGKV1-17 8548204 339849 overexpression of the entire rne gene *results* in a 3-fold increase in [RNase] E activity . Positive_regulation RNASE7 IL17A 23555696 2767381 and IFN-? synergistically *induce* [RNase 7] expression via STAT3 in primary keratinocytes . Positive_regulation RNASE7 IL17A 23555696 2767383 Therefore we investigated the influence of STAT3 on the -mediated [RNase 7] *induction* . Positive_regulation RNASE7 IL17A 23555696 2767385 The use of a STAT3 inhibitor as well as siRNA mediated downregulation of STAT3 resulted in a diminished -mediated [RNase 7] *induction* in keratinocytes indicating that STAT3 is involved in this process . Positive_regulation RNASE7 IL1A 20967562 2424761 Blocking the MAPKs resulted in inhibition of [RNase-7] expression in *response* to . Positive_regulation RNASE7 IL1A 20967562 2424763 However , [RNase-7] *induction* by was not affected by inhibiting the NF-?B signalling pathway . Positive_regulation RNASE7 INS 9705151 525853 The increase in [RNase] activity *induced* by could be prevented by treatment of cultured rat hepatocytes with actinomycin D , indicating that ongoing gene transcription was required . Positive_regulation RNASE7 MCOLN1 8576137 350185 In this present report , we describe the differential effects of these mutations on [RNase] H activity in vitro in the *presence* of versus Mn2+ : mutants delta C and delta 5E were active in the presence of the less biologically relevant Mn2+ and not in the presence of Mg2+ . Positive_regulation RNASE7 MCOLN1 8710510 371291 The Pac1 [RNase] produces 5'-phosphate termini and *requires* ; Positive_regulation RNASE7 MCOLN1 9888800 585188 In contrast , the rnh ( rnhB ) gene product ( RNase HII ) showed a preference for Mn2+ , as did E. coli RNase HII , whereas the ysgB ( rnhC ) gene product ( RNase HIII ) exhibited a *dependent* [RNase] H activity . Positive_regulation RNASE7 NPS 21268581 2392738 We demonstrate that polyvalent DNA functionalized gold nanoparticles ( DNA-Au ) selectively *enhance* [ribonuclease H (RNase H)] activity while inhibiting most biologically relevant nucleases . Positive_regulation RNASE7 NR3C2 18691036 1949481 Based on our earlier report that *induce* a [ribonuclease (RNase)] that inhibits HIV-1 replication , we proposed that maternal-fetal alloantigen stimulation activates factors that protect the fetus against vertically transmitted infections . Positive_regulation RNASE7 PCNA 21245041 2425526 *directs* type 2 [RNase] H activity on DNA replication and repair substrates . Positive_regulation RNASE7 PCNA 21245041 2425538 binding *promotes* [RNase] HII activity in a hinge dependent manner . Positive_regulation RNASE7 POLR2A 22869737 2646935 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE7 POLR2B 22869737 2646936 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE7 POLR2C 22869737 2646937 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE7 POLR2D 22869737 2646938 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE7 POLR2E 22869737 2646939 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE7 POLR2F 22869737 2646940 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE7 POLR2G 22869737 2646941 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE7 POLR2H 22869737 2646942 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE7 POLR2I 22869737 2646943 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE7 POLR2J 22869737 2646944 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE7 POLR2K 22869737 2646945 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE7 POLR2L 22869737 2646946 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE7 PSMA1 18346191 2008301 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE7 PSMA2 18346191 2008302 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE7 PSMA3 18346191 2008303 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE7 PSMA4 18346191 2008304 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE7 PSMA5 18346191 2008305 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE7 PSMA6 18346191 2008306 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE7 PSMA7 18346191 2008307 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE7 PSMB1 18346191 2008308 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE7 PSMB2 18346191 2008309 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE7 PSMB3 18346191 2008310 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE7 PSMB4 18346191 2008311 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE7 PSMB5 18346191 2008312 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE7 PSMB6 18346191 2008313 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE7 PSMB7 18346191 2008314 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE7 PSMC1 18346191 2008315 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE7 PSMC2 18346191 2008316 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE7 PSMC3 18346191 2008317 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE7 PSMC4 18346191 2008318 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE7 PSMC5 18346191 2008319 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE7 PSMC6 18346191 2008320 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE7 PSMD13 18346191 2008321 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE7 PSMD4 18346191 2008322 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Positive_regulation RNASE7 RECQL4 9153317 431307 We propose that the effect of PNA is exclusively due to steric hindrance , as we found no signs of RNA degradation that would indicate PNA mediated [RNase] H *activation* of the tested . Positive_regulation RNASE7 RNASE3 20213669 2367707 , also known as human RNase 3 , belongs to the mammalian RNase A superfamily and its [RNase] activity is *required* for some of its biological properties . Positive_regulation RNASE7 RNH1 8486718 219149 In contrast to RNase A , onconase is resistant to two [RNase] *inhibitors* , and Inhibit-Ace . Positive_regulation RNASE7 RNH1 8969838 402749 RT-PCR is carried out ( i ) by rapidly freezing cells in the presence of ( [RNase] *inhibitor* ) plus dithiothreitol and ( ii ) by using extracts of 250 or fewer cells directly in the RT-PCR assay . Positive_regulation RNASE7 RPA1 9166765 432536 Our studies also demonstrated that *stimulated* the [RNase] H activity of RTH1 nuclease significantly . Positive_regulation RNASE7 RPA2 9166765 432537 Our studies also demonstrated that *stimulated* the [RNase] H activity of RTH1 nuclease significantly . Positive_regulation RNASE7 RPAP1 22869737 2646930 Though the host ( redirected to accept RNA templates ) *mediates* RNA synthesis and a type-III [RNase] presumably cleavage of Potato spindle tuber viroid ( PSTVd ) and closely related members of the family Pospiviroidae , the host enzyme catalyzing the final circularization step , has remained elusive . Positive_regulation RNASE7 RPP21 16142906 1451403 The human protein is *essential* for human [RNase] P activity in tRNA processing in vitro . Positive_regulation RNASE7 SAMHD1 25038827 2953326 Furthermore , phosphorylation of at T592 negatively *regulates* its [RNase] activity in cells and impedes HIV-1 restriction . Positive_regulation RNASE7 TCF7 24460393 2933110 We found that gene function was knocked down by 2',4'-BNA AONs that target the start codon and *induce* [RNase] H activity . Positive_regulation RNASE7 TLR2 18211964 1895500 Additional host defense functions characterized specifically for the RNase eosinophil derived neurotoxin include reducing infectivity of RNA viruses for target cells in culture , which does require [RNase] activity , chemoattraction of immature human dendritic cells via a G-protein coupled receptor dependent mechanism , and *activation* of . Positive_regulation RNASE7 TRAF3 10087233 599777 Influenza virus RNA polymerase with the subunit structure PB1-PB2-PA is involved in both transcription and replication of the RNA genome , including the unique *dependent* [RNase] activity . Positive_regulation RNASE7 TRAF3 10087233 599789 To map the important domains for RNA polymerization , *dependent* [RNase] , and cap-I binding activity , we generated site-specific antibodies against overlapping 150-amino-acid peptides that cover each entire subunit . Positive_regulation RNASE7 TRAF3 10087233 599825 Those against PB1 and PB2 inhibited the *dependent* [RNase] activity , but those against PB2 alone slightly inhibited the cap-I binding activity . Positive_regulation RNASE7 TRAF3 10087233 599849 and amino acids 301-517 and 601-716 of PA inhibited the *dependent* [RNase] activity . Positive_regulation RNASE7 TRH 1324930 195091 Here we show that *regulates* [RNase] activity in GH3 cells and that specific mRNA sequences are needed for in vivo regulation of TRH-R mRNA by TRH . Positive_regulation RNASE7 TRH 1324930 195127 These data show that *regulates* [RNase] activity in GH3 cells , that the 3'-untranslated region bestows decreased stability on TRH-R mRNA and that the 3 ' end of the mRNA is necessary for regulation by TRH of TRH-R mRNA degradation . Positive_regulation RNASE7 TYR 11994277 961733 Replacing His-427 and with Ala and Asp-469 with Asn *resulted* in reduced [RNase] H activity in the presence of Mg ( 2+ ) , whereas in the presence of Mn ( 2+ ) these mutants displayed a lack of turnover . Positive_regulation RNASE7 XBP1 24812669 2939897 Because expression *requires* the [RNase] activity of the ER transmembrane receptor IRE-1 , we developed a potent IRE-1 RNase inhibitor through chemical synthesis and modified the structure to facilitate entry into cells to target the IRE-1/XBP-1 pathway . Positive_regulation RNASEL CAPN8 16277015 1480458 The 2-5A synthetase/RNase L pathway in CFS patients appears to be both up-regulated ( i.e. increased levels of bioactive 2-5A synthetase and increased activity of the RNase L enzyme ) and deregulated ( elastase and *initiate* 83 kDa [RNase L] proteolysis , generating two major fragments with molecular masses of 37 and 30 kDa , respectively ) . Positive_regulation RNF11 TNF 19131965 2042490 [RNF11] negatively regulated RIP1 and TRAF6 ubiquitination upon *stimulation* with and LPS , respectively . Positive_regulation RNF150 NOTCH1 11740941 887005 signaling in Drosophila *requires* a [RING finger (RF) protein] encoded by neuralized . Positive_regulation RNF150 NOTCH2 11740941 887006 signaling in Drosophila *requires* a [RING finger (RF) protein] encoded by neuralized . Positive_regulation RNF150 NOTCH3 11740941 887007 signaling in Drosophila *requires* a [RING finger (RF) protein] encoded by neuralized . Positive_regulation RNF150 NOTCH4 11740941 887008 signaling in Drosophila *requires* a [RING finger (RF) protein] encoded by neuralized . Positive_regulation RNF19A CD14 12117913 964645 Lipopolysaccharide binding protein- and dependent *activation* of mitogen activated protein kinase [p38] by lipopolysaccharide in human neutrophils is associated with priming of respiratory burst . Positive_regulation RNF19A EPHB2 23570600 2768002 PGE1 time-dependently *induced* both phosphorylation of ERK and [p38] in HUVEC , whereas inhibitor , PD98059 , or p38 inhibitor , SB203580 , blocked PGE1 induced VEGF expression of HUVEC , resulting in dramatically suppression of HUVEC proliferation and migration compared with PGE1 treatment alone ( 60 % and 55 % by PD98059 , 62 % and 51 % by SB203580 , respectively ) ; Positive_regulation RNF19A FAS 15317908 1286370 Death promoting effects have been ascribed to inhibition of nuclear factor-kappaB , increase of expression , p53 stabilization , cytokine and chemokine release , and *activation* of nitric oxide synthase , [p38] , and c-Jun-N-terminal kinase . Positive_regulation RNF19A TNF 15001576 1236983 The receptor associated factor ( TRAF ) protein family members are critically *involved* in activation of NF-kappaB , JNK , and [p38] activation triggered by tumor necrosis factor (TNF) receptor family members and toll/interleukin-1 receptor ( TIR ) -containing receptors . Positive_regulation RNF19A TNF 18796294 1976162 Subsequently , *activated* ERK , JNK and [p38] in apoptosis and autophagy , in which ERK/JNK played a promoting role whereas p38 played an inhibiting one . Positive_regulation RNF19A TNF 22294037 2586296 Nocodazole increases the ERK activity to enhance MKP-1expression which inhibits [p38] activation *induced* by . Positive_regulation RNF19A TNFSF10 21109947 2366192 *induced* [caspase/p38] activation is responsible for the increased catalytic and invasive activities of Akt . Positive_regulation RNF19A TNFSF10 21152872 2373378 MEKK1/MEKK4 are responsible for *induced* [JNK/p38] phosphorylation . Positive_regulation RNF2 ID1 20697353 2335473 *enhances* [RING1b] E3 ubiquitin ligase activity through the Mel-18/Bmi-1 polycomb group complex . Positive_regulation RNF2 ID1 20697353 2335483 Finally , we examined the activity of E3 ligase RING1b , whose catalytic activity is increased by binding with the RING finger protein Bmi-1 , and found that overexpression *enhanced* [RING1b] E3 ligase activity leading to accumulation of H2A ubiquitination and ubiquitin/proteasome mediated degradation of geminin . Positive_regulation RNF2 TNF 16386180 1494187 Cytokines are the direct mediators for multiple organ failure (MOF) , and [MOF] is *triggered* by and a cascade of cytokine release , with a prolonged high-expression of IL-6 . Positive_regulation RNGTT F2R 12506061 1038276 [HCE-T] expression of cytokines ( IL-6 , IL-8 , and TNFalpha ) in *response* to activation of and -2 was measured by quantitative RT-PCR and ELISA . Positive_regulation RNGTT TNF 17763126 1790288 *Stimulation* of [HCE] with either IL-1alpha or increased IP-10 protein synthesis up to 6-fold , whereas insignificant levels of MIG and I-TAC were induced . Positive_regulation ROCK1 EPHB2 22215561 2537686 [ROCK1] *induces* nuclear translocation in PDGF-BB stimulated migration of rat vascular smooth muscle cells . Positive_regulation ROCK1 NEDD9 11801728 902778 Finally , cDNA expression array analysis and subsequent studies indicate that production *increases* levels of mRNA transcripts encoding proteins that are associated with motility , cell transformation and invasiveness , including several metalloproteinases , MLCK , [p160ROCK] and ErbB2 . Positive_regulation RORC DLL4 19494260 2091497 Regulation of T cell activation by Notch ligand , , *promotes* IL-17 production and [Rorc] activation . Positive_regulation RORC HNRNPF 22643849 2686833 CD103+ expressed genes associated with promotion of IL-17/IL-22+ cells , and coculture of CD103+ DCs and naïve T cells *led* to increased IL17A and [RORc] expression in differentiating T cells . Positive_regulation RORC HNRNPH1 22643849 2686834 CD103+ expressed genes associated with promotion of IL-17/IL-22+ cells , and coculture of CD103+ DCs and naïve T cells *led* to increased IL17A and [RORc] expression in differentiating T cells . Positive_regulation RORC ICOS 20980695 2338693 stimulation *induced* c-MAF , [RORC2] , and T-bet expression in these cells , leading to increased secretion of interleukin-21 (IL-21) , IL-17 , and interferon-? ( IFN-? ) compared with cells stimulated with CD28 . Positive_regulation RORC ICOS 24729612 2935876 However , in the B16-F10 metastasized lungs , also *increased* [IL-17A/RORc] and decreased IL-10/Foxp3 expression , which indicates that it also exerts positive effects on the antitumor immune response . Positive_regulation RORC IL21 20079789 2218712 potently enhances Th17 proliferation and suppresses Foxp3 expression , *leading* to the expression of [RORC] . Positive_regulation RORC KLRB1 20486123 2315529 is a marker of all human IL-17 producing T-cell subsets and is *induced* by [RORC] . Positive_regulation RORC PTBP1 22643849 2686835 CD103+ expressed genes associated with promotion of IL-17/IL-22+ cells , and coculture of CD103+ DCs and naïve T cells *led* to increased IL17A and [RORc] expression in differentiating T cells . Positive_regulation RORC PTBP2 22643849 2686832 CD103+ expressed genes associated with promotion of IL-17/IL-22+ cells , and coculture of CD103+ DCs and naïve T cells *led* to increased IL17A and [RORc] expression in differentiating T cells . Positive_regulation RORC SETD2 24142705 2932431 *induced* [RORC] expression in Tregs may play a key role in the pathogenesis of nasal polyps . Positive_regulation RPAP1 EDN2 12368904 998441 A preferential role for Cdk9 was shown in [RNA polymerase II] phosphorylation and growth *induced* by , using pharmacological and dominant negative inhibitors . Positive_regulation RPAP1 IL1B 12649265 1080000 induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and *stimulated* [RNA polymerase II] binding to the COX-2 promoter , COX-2 transcription , COX-2 protein synthesis , and prostaglandin E2 ( PGE2 ) release . Positive_regulation RPAP1 TNF 18688044 1961005 *induced* inflammatory gene expression , H3K4me2 levels , and recruitment of [RNA polymerase II] at the gene promoters were also enhanced in db/db VSMCs , demonstrating the formation of open chromatin poised for transcriptional activation in diabetes . Positive_regulation RPAP1 TNF 19734226 2139664 Furthermore , chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and [RNA polymerase II] to the CXCL8 promoter of asthmatic HASM cells both in the *presence* and absence of stimulation . Positive_regulation RPE BPI 17012258 1629176 , but not control protein thaumatin , activated extracellular regulated kinase (ERK) and AKT , and *increased* DNA synthesis in [RPE] and RPC but not in REC . Positive_regulation RPE IL1B 1530600 200038 However , PCR by using cDNA prepared from *stimulated* [RPE] cells revealed expression of the gene , suggesting in vivo production of TNF-alpha from RPE cells in response to IL-1 beta . Positive_regulation RPE IL1B 9441701 475944 Substantial dose- and time dependent [RPE] secretion of IL-8 was *observed* following stimulation with or TNF-alpha , but cell associated IL-8 was detectable only after high dose ( 20 ng ml-1 ) IL-1 beta stimulation and comprised less than 1 % of the total IL-8 induced . Positive_regulation RPE IL1B 9441701 475949 Dose- and time dependent [RPE] cell MCP-1 secretion was also *observed* following > TNF-alpha > IFN-gamma stimulation , with an average of 4 % of the total MCP-1 retained within RPE . Positive_regulation RPE RAB31 21905166 2506644 Overall , our results indicate that the geranyl-geranyl transferase interaction and consequently REP1 mediated Rab prenylation is *essential* for [RPE] and photoreceptor function . Positive_regulation RPE TNF 15728563 1377343 To investigate the mechanism underlying apoptosis in [retinal pigment epithelium (RPE)] *induced* by in conditions of heavy metal ion deficiency . Positive_regulation RPE TNF 8943702 400127 Interleukin-7 potentiated *induced* [RPE] monocyte chemotactic protein-1 steady-state mRNA expression at all doses of interleukin-7 while only high dose interleukin-7 ( 100 ng ml-1 ) enhanced tumor necrosis factor-alpha induced RPE interleukin-8 steady-state gene expression . Positive_regulation RPE TNF 9441701 475943 Substantial dose- and time dependent [RPE] secretion of IL-8 was *observed* following stimulation with IL-1 beta or , but cell associated IL-8 was detectable only after high dose ( 20 ng ml-1 ) IL-1 beta stimulation and comprised less than 1 % of the total IL-8 induced . Positive_regulation RPE TNF 9441701 475947 Dose- and time dependent [RPE] cell MCP-1 secretion was also *observed* following IL-1 beta > > IFN-gamma stimulation , with an average of 4 % of the total MCP-1 retained within RPE . Positive_regulation RPF1 EDN2 8304480 249010 In the isolated perfused rat kidney , added to the perfusate at concentrations ranging from 50 to 500 pmol/l *resulted* in a dose dependent reduction in [renal perfusate flow (RPF)] and inulin clearance ( CIn ) . Positive_regulation RPF2 EDN2 8304480 249007 In the isolated perfused rat kidney , added to the perfusate at concentrations ranging from 50 to 500 pmol/l *resulted* in a dose dependent reduction in [renal perfusate flow (RPF)] and inulin clearance ( CIn ) . Positive_regulation RPH3AL RAB31 11498010 846597 Using this approach we have demonstrated an inhibitory role for the putative Rab3 effector [Noc2] that *requires* interaction with . Positive_regulation RPH3AL RAB31 15159548 1252662 Accordingly , [Noc2] positively regulates insulin secretion from endocrine pancreas by inhibiting Gi/o signaling , and the interaction of Noc2 and is *required* for the effect . Positive_regulation RPL17 NT5E 23983257 2851010 Targeting *enhances* the antitumor activity of [anti-PD-1] and anti-CTLA-4 mAbs . Positive_regulation RPL17 STAT4 24711622 2935586 STAT3 , , NFATc1 , and CTCF *regulate* [PD-1] through multiple novel regulatory regions in murine T cells . Positive_regulation RPL18 TNF 24611904 2933912 On average , [L18-MDP] *induced* production in 25 % of monocytes from healthy donors or female carriers , while fewer than 6 % of monocytes responded in affected patients . Positive_regulation RPL22 AGR2 18268030 1885018 In iron restricted growth conditions , Sae and are *essential* for Emp and [Eap] expression and hence for biofilm formation , whereas SarA appears to have a less-significant role . Positive_regulation RPLP0 EDN2 9513855 492100 further *increased* ( from 4.4 +/- 0.8 to 9.14 +/- 1.8 [pmol/L; p < 0.01] ) after transplantation . Positive_regulation RPLP0 TNF 19149923 2026722 Plasma levels in obese children significantly *increased* compared to normal children ( 171.38+/-34.33 ng/L vs 91.07+/-21.60 [ng/L; p<0.01] ) and positively correlated with BMI , WHR , % BF , fasting insulin , HOMA-IR , TG and systolic blood pressure ( p < 0.01 ) , and negatively with HDL ( p < 0.05 ) . Positive_regulation RPS24 TNF 14566398 1155050 ( 3 ) in Balb/c 3T3 cells dexamethasone and TNF-alpha acted synergistically to induce the expression of SIP24/24p3 , whereas in BNL cells dexamethasone and *induced* the expression of [SIP24/24p3] in an additive manner ; Positive_regulation RPS27 STK39 18083840 1836912 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation RPS6 CTGF 23415771 2764672 Importantly , overexpression in serum starved 3T3 cells using adenovirus *led* to phosphorylation of [ribosomal protein S6] , a downstream target of mTOR . Positive_regulation RPS6 EPHB2 17360704 1734089 signaling *promotes* site-specific [ribosomal protein S6] phosphorylation via RSK and stimulates cap dependent translation . Positive_regulation RPS6KA1 EPHB2 10469565 641228 [Ribosomal S6 kinase 1 (RSK1)] activation *requires* signals dependent on and independent of the MAP kinase . Positive_regulation RPS6KA1 EPHB2 10469565 641229 Nevertheless , activation of full-length [RSK1] in the absence of serum *required* activation by both PDK1 and . Positive_regulation RPS6KA1 EPHB2 10469565 641233 Activation of phosphotransferase activity of full-length [RSK1] in vivo *requires* both PDK1 and . Positive_regulation RPS6KA1 EPHB2 17000106 1640865 Of the 13 compounds tested , 4 compounds strongly inhibited *mediated* phosphorylation of [ribosomal S6 kinase-1 (Rsk-1)] and/or the transcription factor Elk-1 and inhibited the proliferation of HeLa cervical carcinoma cells with IC ( 50 ) values in the 2-10 microM range . Positive_regulation RPS6KA1 EPHB2 17627032 1770181 Here , we show for the first time that in all four brain lesions and one angiomyolipoma from TS patients both extracellular signal regulated kinase ( Erk ) and p90 ribosomal S6 kinase 1 activation as well as *dependent* phosphorylation of p70 [ribosomal S6 kinase 1] are markedly elevated whereas Akt , participating in the classical pathway of mammalian target of rapamycin activation is not always activated . Positive_regulation RPS6KA1 EPHB2 24755224 2950140 PLK and ERK RNAi showed that Ar-Rsk2 , but not [Ar-Rsk1] , could be *activated* by in Artemia . Positive_regulation RPS6KA1 IL1B 10965886 728046 In addition , the MAP kinase-kinase MEK-1 and the ribosomal S6-kinase [RSK-1] are also phosphorylated in *response* to . Positive_regulation RPS6KA3 EPHB2 17785202 1790526 We found that FGFR3 directly tyrosine phosphorylates the serine/threonine kinase p90RSK2 at Y529 , which consequently regulates RSK2 activation by facilitating inactive ERK binding to RSK2 that is required for *dependent* phosphorylation and activation of [RSK2] . Positive_regulation RPS6KA3 EPHB2 23725048 2848878 also *activates* [RSK2] , which in turn phosphorylates ATF4 , a transcriptional regulator of late-stage osteoblast synthetic functions . Positive_regulation RPS6KA3 EPHB2 24755224 2950142 PLK and ERK RNAi showed that [Ar-Rsk2] , but not Ar-Rsk1 , could be *activated* by in Artemia . Positive_regulation RPS6KA4 TNF 17023264 1630458 Supporting this notion , cotreatment with NAC inhibited the *induced* rise in MSK1 and [MSK2] kinase activity , while siRNA knock-down experiments showed that MSK2 is the predominant isoform involved in TNF-alpha induced ET-1 upregulation . Positive_regulation RPS6KA5 EPHB2 10625698 658946 Stimulation of [MSK1] in contracting skeletal muscle *required* the activation of both and p38 ( MAPK ) . Positive_regulation RPS6KA5 EPHB2 12690113 1099957 Our results also indicate that the *activation* of mitogen- and stress activated protein kinase 1 ( [MSK1] ) and cAMP-response element binding protein and cAMP-response element signaling cascades via and p38 MAP kinases are crucial aspects of the intracellular mechanisms that mediate MUC5AC gene expression . Positive_regulation RPS6KA5 EPHB2 17081988 1643154 Five minutes after hormone treatment , activation *leads* to phosphorylation of the progesterone receptor (PR) , activation of [Msk1] , and recruitment of a complex of the three proteins to a nucleosome on the MMTV promoter . Positive_regulation RPS6KA5 EPHB2 17196532 1680519 Ca2+ -stimulated adenylyl cyclases regulate *dependent* activation of [MSK1] during fear conditioning . Positive_regulation RPS6KA5 TLR7 19922413 2190140 [MSK1] regulates the transcription of IL-1ra in *response* to activation in macrophages . Positive_regulation RPS6KA5 TNF 14761884 1207150 From among the kinases that can activate CREB , we found that downstream of p38 MAPK , [MSK1] is *activated* by to promote CREB activation . Positive_regulation RPS6KA5 TNF 17023264 1630459 Supporting this notion , cotreatment with NAC inhibited the *induced* rise in [MSK1] and MSK2 kinase activity , while siRNA knock-down experiments showed that MSK2 is the predominant isoform involved in TNF-alpha induced ET-1 upregulation . Positive_regulation RPS6KA5 TNF 17913704 1830211 Together with cPLA(2) redistribution and AA release , *induced* a time dependent phosphorylation of ERK , [MSK1] , PKCzeta , CaMKII , and phospholamban on the threonine 17 residue . Positive_regulation RPS6KA5 TNF 21334436 2415226 Desialylation completely abolished darbepoetin alfa 's inhibitory effects on *induced* ROS accumulation , [MSK1] activation , and ET-1 gene expression , without affecting its stimulation of STAT5 activity . Positive_regulation RPS6KB1 EPHB2 12909616 1150814 Studies using specific inhibitors and dominant negative c-Raf expression in cardiomyocytes indicate that the [S6K1] activation *involves* mTOR , , and phosphatidylinositol 3-kinase pathways and is independent of protein kinase C and c-Raf . Positive_regulation RPS6KB1 MAP2K6 12909616 1150821 Studies using specific inhibitors and dominant negative c-Raf expression in cardiomyocytes indicate that the [S6K1] activation *involves* mTOR , , and phosphatidylinositol 3-kinase pathways and is independent of protein kinase C and c-Raf . Positive_regulation RPS6KB1 TNF 18952604 2001046 [S6K1] is also *activated* by , a pro-inflammatory cytokine . Positive_regulation RPS6KB1 TNF 18952604 2001047 [S6K1] was phosphorylated at Thr-389 in *response* to . Positive_regulation RPS6KB2 MAP2K6 11431469 850003 dependent *activation* of [S6K2] in cardiomyocytes . Positive_regulation RPS6KB2 STK39 8310048 241176 In contrast , labeling was not observed when lysine-524 , a residue conserved among all protein kinases , was mutated to arginine , thus confirming that [SRK] phosphorylation was the *result* of intrinsic activity . Positive_regulation RPSA MAP2K6 19998339 2272089 Furthermore , U0126 , the inhibitor , *inhibited* hypoxia- and MEK induced [MGr1-Ag/37LRP] promoter activity in a dose dependent manner . Positive_regulation RPTOR EPHB2 20512842 2270610 We found that low concentrations rapamycin increased Akt and ERK phosphorylation through a mTORC1 dependent mechanism because knockdowned [raptor] *induced* the activation of Akt and , but higher doses of rapamycin inhibited Akt and ERK phosphorylation mainly via the mTORC2 signaling pathway because that the silencing of rictor led to the inhibition of Akt and ERK phosphorylation . Positive_regulation RPTOR EPHB2 21289294 2419955 Previous studies have shown that , in part , Akt and *promote* [mTORC1] signaling through phosphorylation of a GTPase activator protein (GAP) , referred to as tuberous sclerosis complex 2 (TSC2) , that acts as an upstream inhibitor of mTORC1 . Positive_regulation RPTOR EPHB2 21659537 2459596 Our data also reveal striking diversity in the *requirements* for in the control of [mTORC1] between different cell types , pointing to additional signaling connections between phorbol esters and mTORC1 , which do not involve MEK/ERK . Positive_regulation RPTOR EPHB2 23431403 2744415 Absence of kinase suppressor of Ras 1 (KSR1) , a scaffold protein of the ERK signaling pathway , or inhibition of *resulted* in decreased [mTORC1] activity following T cell activation . Positive_regulation RPTOR MAP2K6 21659537 2459558 Previous work indicated that [mTORC1] activation by the phorbol ester PMA ( phorbol 12-myristate 13-acetate ) depends upon PKCs and may *involve* . Positive_regulation RPTOR MAP2K6 21659537 2459602 Our data also reveal striking diversity in the *requirements* for in the control of [mTORC1] between different cell types , pointing to additional signaling connections between phorbol esters and mTORC1 , which do not involve MEK/ERK . Positive_regulation RPTOR MAP2K6 21738705 2452326 Inhibition of with drugs *caused* only modest [mTORC1] inhibition , implying that other unidentified pathways also play major roles . Positive_regulation RRAS EDN2 18784646 2012155 Further , C3G over-expression enhanced the activation of [R-Ras] in *response* to . Positive_regulation RRAS PECAM1 10725328 677536 Importantly , selectively *activated* the small Ras related GTPase , Rap1 , but not Ras , [R-Ras] , or Rap2 . Positive_regulation RRN3 EPHB2 12620228 1066195 *dependent* phosphorylation of the transcription initiation factor [TIF-IA] is required for RNA polymerase I transcription and cell growth . Positive_regulation RTN4R TNF 18524667 1922958 The nerve growth factor receptor p75 , a TNF family receptor , is absent or poorly expressed in certain types of neurons that respond to myelin inhibitors , thereby prompting speculation that other family receptors are *involved* in the [NgR1] complex . Positive_regulation RUNX1 EPHB2 16368886 1539724 Thrombopoietin regulates IEX-1 gene expression through *induced* [AML1] phosphorylation . Positive_regulation RUNX1 EPHB2 16368886 1539727 Here we show that the regulation of the immediate early gene X-1 (IEX-1) , identified as an ERK substrate in response to TPO , was mediated by an *dependent* phosphorylation of [AML1] . Positive_regulation RUNX1 EPHB2 16368886 1539732 Taken together , these data suggest that AML1 plays a role in modulating the IEX-1 expression and that the *dependent* [AML1] phosphorylation regulates the TPO mediated activation of IEX-1 . Positive_regulation RUNX1 MAP2K6 10744637 680626 A concomitant increase in p38 phosphorylation was also inhibited by SNAP , but whereas inhibitor ( PD98059 ) *suppressed* elastase and [AML1B-DNA] binding , a p38 inhibitor ( SB202190 ) did not . Positive_regulation RUNX1 TNF 23765556 2854156 also *increased* mineralisation and the expression of bone morphogenetic protein 2 (BMP2) , alkaline phosphatase (ALP) , [runt related transcription factor] 2 ( RUNX2 ) and collagen type I ( COL I ) during this process . Positive_regulation RUNX1 TP63 18275068 1924781 Taken together our data demonstrate that directly *regulates* [Runx1] gene expression through a novel enhancer element and suggests a role for these two transcription factors in dictating skin keratinocyte and appendage development . Positive_regulation RUNX2 CCND1 19351720 2064790 PTHrP prevents chondrocyte premature hypertrophy by inducing *dependent* [Runx2] and Runx3 phosphorylation , ubiquitylation and proteasomal degradation . Positive_regulation RUNX2 CCND1 19351720 2064792 We recently demonstrated that *induces* [Runx2] protein phosphorylation and degradation . Positive_regulation RUNX2 EPHB2 11784711 922007 Superoxide mediates shock wave induction of *dependent* osteogenic transcription factor ( [CBFA1] ) and mesenchymal cell differentiation toward osteoprogenitors . Positive_regulation RUNX2 EPHB2 14596931 1160368 Moreover , inhibition of activity by PD98059 *suppressed* US augmentation of [Cbfa1/Runx2] and osteocalcin mRNA expression . Positive_regulation RUNX2 EPHB2 14602722 1200295 Finally , we show that Notch and activation are *essential* for [Runx2] DNA binding activity and osteocalcin gene expression in C4-2B cells in response to osteogenic induction . Positive_regulation RUNX2 EPHB2 15564063 1341385 Inhibitors of signaling blocked up-regulation of the MMP-13 promoter by RUNX2 and FGF2 , and also *blocked* the activation of [RUNX2] by FGF2 . Positive_regulation RUNX2 EPHB2 20007706 2199908 We previously demonstrated that activation does not affect Runx2 gene expression but that it *stimulates* [Runx2] transcriptional activity . Positive_regulation RUNX2 EPHB2 20007706 2199910 However , the molecular mechanism underlying [Runx2] *activation* by FGF/FGFR or was still unclear . Positive_regulation RUNX2 EPHB2 20007706 2199944 As [Runx2] protein phosphorylation *mediated* by directly correlates with Runx2 protein stabilization , acetylation , and ubiquitination , we undertook to identify the ERK dependent phosphorylation sites in Runx2 . Positive_regulation RUNX2 EPHB2 20828597 2336533 Saponins from the roots of Platycodon grandiflorum stimulate osteoblast differentiation via p38 MAPK- and *dependent* [RUNX2] activation . Positive_regulation RUNX2 EPHB2 20828597 2336535 CKS induced enhancement of [RUNX2] and ALP was *inhibited* by treatment with a p38 inhibitor ( SB203580 ) and an inhibitor ( U0126 ) . Positive_regulation RUNX2 EPHB2 20851880 2342784 activation by overexpression of constitutively active MEK1 *increased* [Runx2] transcriptional activity , whereas U0126 , an inhibitor of MEK1/2 , suppressed basal Runx2 transcriptional activity and BMP induced Runx2 acetylation and stabilization . Positive_regulation RUNX2 EPHB2 20851880 2342785 On the other hand , knockdown of Smad1 and Smad5 by siRNA suppressed both basal and *induced* [Runx2] protein levels . Positive_regulation RUNX2 EPHB2 20851880 2342787 activation *enhanced* the association of [Runx2] with p300 and Smad1 . Positive_regulation RUNX2 EPHB2 20851880 2342789 Taken together these results indicate that signaling *increases* [Runx2] stability and transcriptional activity , partly via increasing p300 protein levels and histone acetyltransferase activity and subsequently increasing Runx2 acetylation by p300 . Positive_regulation RUNX2 EPHB2 22072425 2585390 Significantly , in the presence of AA , BMP2/7 synergistically stimulated [RUNX2] S319 phosphorylation and transcriptional activity without affecting total RUNX2 and this response was totally *dependent* on activity . Positive_regulation RUNX2 EPHB2 22337141 2617728 These findings establish *mediated* phosphorylation of [RUNX2] as a critical step in the response of preosteoblasts to dynamic loading and define a novel mechanism to explain how mechanical signals induce gene expression in bone . Positive_regulation RUNX2 FHL1 19230833 2086547 Inhibition of by RNA interference *resulted* in the decreased activity of [Runx2] in osteoblasts . Positive_regulation RUNX2 FOXO1 21471200 2433548 In this study , we determined the molecular mechanisms whereby forkhead transcription factor , a key downstream signaling molecule of insulin-like growth factor 1 (IGF1)/insulin actions , *regulates* [Runx2] activity and expression of the mouse osteocalcin gene 2 ( Bglap2 ) in osteoblasts in vitro . Positive_regulation RUNX2 IL1B 16549373 1582334 Furthermore , *induced* the phosphorylation of [Runx2] , and this effect was blocked by a p38 kinase inhibitor . Positive_regulation RUNX2 MAP2K6 15564063 1341392 Inhibitors of signaling blocked up-regulation of the MMP-13 promoter by RUNX2 and FGF2 , and also *blocked* the activation of [RUNX2] by FGF2 . Positive_regulation RUNX2 TNF 11723115 896997 Our results indicate that *regulates* [RUNX2] expression at multiple levels including destabilization of mRNA and suppression of transcription . Positive_regulation RUNX2 TNF 12417072 1012929 in combination with BMP-2 could *induce* fibroblasts to express [Cbfa1] and osteocalcin mRNA . Positive_regulation RUNX2 TNF 15516323 1328537 ( 10ng/ml ) *increased* BSP , IL-6 and COX-2 mRNA levels after 3h , reaching maximal levels at 12 h . [Cbfa1] mRNA levels increased after 3 h , but decreased by 24 h. Osterix , cathepsin B , cathepsin L and TIMP-1 mRNA levels did not change after stimulation with TNF-alpha . Positive_regulation RUNX2 TNF 16373342 1519702 *promotes* [Runx2] degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts . Positive_regulation RUNX2 TNF 22396737 2566831 also induces the expression of E3 ubiquitin ligase protein Smurf1 and Smurf2 and *promotes* degradation of [Runx2] , another key transcription factor regulating osteoblast differentiation and bone formation . Positive_regulation RUNX2 TNF 23765556 2854157 also *increased* mineralisation and the expression of bone morphogenetic protein 2 (BMP2) , alkaline phosphatase (ALP) , runt related transcription factor 2 ( [RUNX2] ) and collagen type I ( COL I ) during this process . Positive_regulation RUNX3 CCND1 19351720 2064791 PTHrP prevents chondrocyte premature hypertrophy by inducing *dependent* Runx2 and [Runx3] phosphorylation , ubiquitylation and proteasomal degradation . Positive_regulation RUNX3 CCND1 19351720 2064802 We found that *induced* [Runx3] degradation in a dose dependent manner and that both Myc tagged Runx3 and endogenous Runx3 interact directly with CDK4 in COS and RCJ3.1C5.18 cells . Positive_regulation RUNX3 MAP2K6 22222375 2544515 MEK-inhibition or Elk-1-knockdown downregulated EZH2 , and or EZH2-knockdown *restored* expression of a tumor suppressor , [RUNX3] in human and rat pancreatic cancer cells activated by the oncogenic RAS . Positive_regulation RUNX3 TNF 23765556 2854158 also *increased* mineralisation and the expression of bone morphogenetic protein 2 (BMP2) , alkaline phosphatase (ALP) , [runt related transcription factor] 2 ( RUNX2 ) and collagen type I ( COL I ) during this process . Positive_regulation RXRA IL1B 12105223 976675 How signaling *leads* to reduced [RXR:RAR] nuclear binding activity is unknown , and we sought to determine whether mitogen activated protein kinase (MAPK) pathways were involved . Positive_regulation RXRA IL1B 19767119 2147424 Redundant roles for cJun-N-terminal kinase 1 and 2 in *mediated* reduction and modification of murine hepatic nuclear [retinoid X receptor alpha] . Positive_regulation RXRB IL1B 11171635 784064 IL-1beta and/or RA did not change the type 1 IL-1 receptor transcript level , whereas *enhanced* the RA-induced expressions of retinoic acid receptor-beta (RAR-beta) and [retinoid X receptor-beta (RXR-beta)] mRNAs and RA-mediated RXR response element binding . Positive_regulation RYK AXIN2 21814488 2462835 Third , [Ppa-LIN-18/Ryk] signaling *involves* and ß-catenin and Ppa-axl-1/Axin is epistatic to Ppa-lin-18/Ryk . Positive_regulation RYR1 CAPN8 11148048 770457 These results demonstrate that the NH ( 2 ) -terminus of the RyR is a molecular target for dantrolene , and suggest a regulatory *role* for both activity and ATP in the interaction of dantrolene with the [RyR] in vivo . Positive_regulation RYR2 CAPN8 11148048 770471 These results demonstrate that the NH ( 2 ) -terminus of the RyR is a molecular target for dantrolene , and suggest a regulatory *role* for both activity and ATP in the interaction of dantrolene with the [RyR] in vivo . Positive_regulation RYR3 CAPN8 11148048 770485 These results demonstrate that the NH ( 2 ) -terminus of the RyR is a molecular target for dantrolene , and suggest a regulatory *role* for both activity and ATP in the interaction of dantrolene with the [RyR] in vivo . Positive_regulation RYR3 EPHB2 18199822 1876287 Thus superoxide induced potentiation requires the redox targeting of [RyR3] and the subsequent *activation* of . Positive_regulation S100A1 S100B 12619862 1065923 [S100A1] is the major isoform in normal heart and , normally a brain protein , is *induced* in hypertrophic myocardium and functions as an intrinsic negative modulator of the hypertrophic response . Positive_regulation S100A11 IL1B 18523305 1922899 Chondrocyte RAGE expression and [S100A11] release are *stimulated* by in vitro and increase in OA cartilage in situ . Positive_regulation S100A11 TNF 16339570 1491681 CXCL8 and *induced* [S100A11] expression and release in cultured chondrocytes . Positive_regulation S100A12 CCL17 23731651 2843825 We sought to determine whether *induces* CCR4 dependent [CGRP] synthesis and secretion by human airway epithelial cells . Positive_regulation S100A12 CCL17 23731651 2843827 *induced* a several thousand-fold increase in [CGRP] mRNA expression and released peptide product from BEAS-2B and A549 cells in a time- and concentration dependent fashion . Positive_regulation S100A12 CCL17 23731651 2843828 Concentration dependent *induced* release of [CGRP] by primary human airway epithelial cells was also observed . Positive_regulation S100A12 CCL17 23731651 2843829 Under comparable conditions , *induced* greater [CGRP] release from BEAS-2B cells than either IL-13 , a cytokine mixture ( TNF-a , GM-CSF , and IL-1 ) , or CCL22 . Positive_regulation S100A12 CCL17 23731651 2843830 *induced* [CGRP] release was inhibited by a specific anti-CCR4 blocking antibody . Positive_regulation S100A12 EPHB2 21933441 2492266 The activation of spinal , p38 and CaMKII , alongside nNOS , is *involved* in chronic morphine induced [CGRP] up-regulation in both the DRG and SCDH . Positive_regulation S100A12 IL1B 10934280 720433 The maximum effect reached almost 600 % of the heat evoked release , and the maximum TNF-alpha effect *induced* a rise in [CGRP] release of 350 % . Positive_regulation S100A12 IL1B 12836161 1107899 The results showed that ( 1 ng/ml ) could directly *induce* [CGRP] release following prolonged incubation ( 24 hr ) with these neurons . Positive_regulation S100A12 IL1B 12836161 1107901 In addition , pretreatment of DRG cells with actinomycin D at 1 microM or cyclohexamide at 10 microM for 30 min inhibited 1 ng/ml *induced* [CGRP] release in DRG neurons of neonatal rats . Positive_regulation S100A12 IL1B 12836161 1107904 The inhibitors of PKC , JNK MAPK and NF-kappaB , but not p38 or ERK1/2 MAPK , blocked *induced* [CGRP] release . Positive_regulation S100A12 IL1B 12836161 1107919 RNase protection assay showed that could *cause* [alpha-CGRP] mRNA increase in a time- and concentration dependent manner , although the level of beta-CGRP mRNA was not affected . Positive_regulation S100A12 IL1B 12836161 1107920 These results indicate that may activate PKC , which in turn initiates JNK MAPK and activates NF-kappaB and finally *induces* [alpha-CGRP] gene expression and release from these sensory neurons . Positive_regulation S100A12 IL1B 15319367 1303741 Proinflammatory factor *induces* [CGRP] release from neuron derived sources . Positive_regulation S100A12 IL1B 15319367 1303743 However , whether can *induce* [CGRP] secretion from a nonneural source , AEII cells , is not known . Positive_regulation S100A12 IL1B 15319367 1303745 In the present study , we demonstrated that human AEII A549 cells expressed beta-CGRP , and ( 0.001-50 ng/ml ) directly *increased* [CGRP] secretion from these cells in a time- and concentration dependent manner . Positive_regulation S100A12 IL1B 15319367 1303747 In addition , we found that *induced* [CGRP] production was mediated through the PKC-p38 mitogen activated protein (MAP) kinase-NF-kappaB signaling pathway . Positive_regulation S100A12 IL1B 17007741 1629010 Our previous data have shown that type II alveolar epithelial ( AEII ) cells express neuropeptide [calcitonin gene related peptide (CGRP)] , and that pro-inflammatory factor *induces* CGRP secretion in the A549 human AEII cell line . Positive_regulation S100A12 IL1B 17007741 1629016 These data imply that AEII cell derived [CGRP] suppress *induced* IL-8 secretion in an autocrine/paracrine mode . Positive_regulation S100A12 IL1B 17481780 1750506 In a previous study , we found that [calcitonin gene related peptide (CGRP)] could be *induced* by proinflammatory factor in A549 human type II alveolar ( AEII ) epithelial cells . Positive_regulation S100A12 IL1B 17481780 1750508 We investigated the mechanism of *induced* [CGRP] secretion and found that the PKC-p38 MAPK-NF-kappaB pathway was involved . Positive_regulation S100A12 IL1B 17481780 1750512 In investigating whether JNK was involved in *induced* [CGRP] secretion , the JNK II inhibitor SP600125 was used and it significantly attenuated IL-1beta induced CGRP secretion and c-Jun activity , which was elevated after IL-1beta stimulation from mRNA to protein level . Positive_regulation S100A12 IL1B 17481780 1750517 These data suggest that besides the PKC-p38 MAPK-NF-kappaB pathway , the JNK-AP-1 pathway is involved in *induced* [CGRP] secretion in A549 human type II alveolar epithelial cells , and a 643-bp site upstream of the transcription start site on the promoter of beta-CGRP is the AP-1 response element . Positive_regulation S100A12 IL1B 8764661 378587 *induced* augmentation of [CGRP] release was blocked by Lys-D-Pro-Thr . Positive_regulation S100A12 MAP2K6 20870010 2346969 Inhibiting activity also *blocks* the ability of NGF to increase [CGRP] expression . Positive_regulation S100A12 TNF 10934280 720432 The maximum IL-1 beta effect reached almost 600 % of the heat evoked release , and the maximum effect *induced* a rise in [CGRP] release of 350 % . Positive_regulation S100A12 TNF 11446746 835438 We recently found that [CGRP] *induces* IL-6 and in long-term bone marrow cultures and that IL-6 and TNF-alpha also inhibit IL-7 responses . Positive_regulation S100A12 TNF 11446746 835444 In contrast , [CGRP] did not *induce* in BMDMs . Positive_regulation S100A12 TNF 15374807 1297943 Furthermore , in vitro [S100A12] secretion *increased* with stimulation , whereas intracellular levels were lower in neutrophils with the higher TNF-alpha dose , suggesting intracellular depletion . Positive_regulation S100A12 TNF 16277606 1502481 *caused* a coordinate increase in [CGRP] promoter activity . Positive_regulation S100A12 TNF 16927957 1603897 Studies in cultured trigeminal neurons demonstrate that [CGRP] is released from trigeminal ganglia cells , that CGRP transcription is increased under conditions mimicking neurogenic inflammation , that migraine pharmacotherapies can both reduce CGRP release and inhibit CGRP transcription , and that , an endogenous inflammatory mediator implicated in migraine , can *stimulate* CGRP transcription . Positive_regulation S100A12 TNS1 2783612 106908 These results suggest that [CGRP] is involved in the *induced* vasodilator response of the large cerebral arteries of the cat . Positive_regulation S100A2 S100B 8903474 393955 S100A1 and [S100A2] can be *detected* in a few normal tissues only , whereas S100A4 , S100A6 , and are expressed at higher levels in cancer tissues . Positive_regulation S100A2 TP63 18388131 1913259 This may indicate a function of the *dependent* [S100A2] regulation in tumor suppression . Positive_regulation S100A4 CTGF 17550972 1752626 Moreover , the cDNA microarray analysis revealed *mediated* regulation of the prometastatic gene [S100A4] . Positive_regulation S100A6 TNF 12859951 1110995 Transient expression of NF-kappaB ( p65 ) increased S100A6 promoter activity and expression of inhibitor of NF-kappaB ( IkappaBalpha ) decreased *induced* [S100A6] promoter activity . Positive_regulation S100A6 TNF 12859951 1111010 These results suggest that NF-kappaB transcription factor contributes to the activation of [S100A6] gene expression in *response* to in HepG2 cells . Positive_regulation S100A6 TNF 18753141 1980018 *induced* the maximal [S100A6] promoter and transcription factor NF-kappaB ( p65 subunit ) . Positive_regulation S100A6 TNF 18753141 1980029 These results demonstrate that [S100A6] is *induced* by via an NF-kappaB dependent mechanism , serving a role in homeostasis to limit tumor necrosis factor-alpha induced apoptosis by regulating p53 phosphorylation . Positive_regulation S100A6 TNF 22829076 2522835 Upregulation of [S100A6] expression and inhibition of the p53-caspase 8-caspase 3 pathway were observed only in MLL-AFF1 positive ALL cell lines in the *presence* of . Positive_regulation S100A7 CAMP 21468384 2413145 Expression of RNase 7 and [psoriasin] was *detected* in all nasal secretion specimens , whereas was detected in 16 , hBD-2 in 5 and hBD-3 in 6 specimens . Positive_regulation S100A7 CTBP1 23000163 2689150 The histone demethylase is *required* for estrogen dependent [S100A7] gene expression in human breast cancer cells . Positive_regulation S100A7 CTBP1 23000163 2689189 Together , our data suggest that estrogen induced [S100A7] expression *mediated* by the histone demethylase may downregulate breast cancer cell proliferation , implying a potential tumor suppressor-like function for S100A7 . Positive_regulation S100A7 CTNNB1 18223693 1919128 More importantly , our results also indicated that signaling negatively *regulates* [S100A7] expression . Positive_regulation S100A7 EGF 18320059 1881083 Here , we showed for the first time that *induces* [S100A7] expression in both MCF-7 and MDA-MB-468 cell lines . Positive_regulation S100A7 ESR2 17009105 1754522 *regulates* [psoriasin] ( S100A7 ) in human breast cancer . Positive_regulation S100A7 ESR2 17009105 1754524 We have previously observed a paradoxical relationship of the psoriasin/S100A7 gene with estrogen response in-vitro in ERalpha positive cells but its association with ERalpha negative status in-vivo raising the possibility that [S100A7] might be *regulated* by in breast cancer . Positive_regulation S100A7 ESR2 17009105 1754527 These data support the hypothesis that [psoriasin/S100A7] is specifically *regulated* by activity and could be useful to guide future therapies targeting ERbeta in certain phenotypic subsets of breast cancers in-vivo . Positive_regulation S100A7 HDAC1 23000163 2689154 The histone demethylase is *required* for estrogen dependent [S100A7] gene expression in human breast cancer cells . Positive_regulation S100A7 HDAC1 23000163 2689193 Together , our data suggest that estrogen induced [S100A7] expression *mediated* by the histone demethylase may downregulate breast cancer cell proliferation , implying a potential tumor suppressor-like function for S100A7 . Positive_regulation S100A7 HMG20A 23000163 2689155 The histone demethylase is *required* for estrogen dependent [S100A7] gene expression in human breast cancer cells . Positive_regulation S100A7 HMG20A 23000163 2689194 Together , our data suggest that estrogen induced [S100A7] expression *mediated* by the histone demethylase may downregulate breast cancer cell proliferation , implying a potential tumor suppressor-like function for S100A7 . Positive_regulation S100A7 HMG20B 23000163 2689156 The histone demethylase is *required* for estrogen dependent [S100A7] gene expression in human breast cancer cells . Positive_regulation S100A7 HMG20B 23000163 2689195 Together , our data suggest that estrogen induced [S100A7] expression *mediated* by the histone demethylase may downregulate breast cancer cell proliferation , implying a potential tumor suppressor-like function for S100A7 . Positive_regulation S100A7 HSPA1B 23000163 2689157 The histone demethylase is *required* for estrogen dependent [S100A7] gene expression in human breast cancer cells . Positive_regulation S100A7 HSPA1B 23000163 2689196 Together , our data suggest that estrogen induced [S100A7] expression *mediated* by the histone demethylase may downregulate breast cancer cell proliferation , implying a potential tumor suppressor-like function for S100A7 . Positive_regulation S100A7 IFNG 17986321 1835724 [S100A7] ( Psoriasin ) , highly expressed in ductal carcinoma in situ ( DCIS ) , is *regulated* by in mammary epithelial cells . Positive_regulation S100A7 IKBKB 16082188 1481884 Furthermore , we demonstrate that overexpression of a dominant negative also *inhibits* the induction of [psoriasin] suggesting that the NFkappaB pathway is involved in the induction of this protein . Positive_regulation S100A7 IL1A 21551409 2449337 Stimulation with and VEGF also strongly *increased* [psoriasin] transcription . Positive_regulation S100A7 IL22 16982811 1628172 in conjunction with IL-17A or IL-17F synergistically induced the expression of beta-defensin 2 and S100A9 and additively *enhanced* the expression of [S100A7] and S100A8 . Positive_regulation S100A7 IL22 23174657 2735840 On the one hand , IFN-? antagonized *mediated* induction of the antimicrobial peptide [S100A7] and epithelial cell migration in bronchial epithelial cells . Positive_regulation S100A7 IL22 23314787 2780753 Interestingly , BE inhibited the *induced* gene expression of AKT1 , MTOR , chemokines [ IL-8 and RANTES ( regulated upon activation , normal T-cell expressed and secreted ) ] , and [psoriasin] ( S100A7 ) more significantly than Vit-D . Positive_regulation S100A7 KDM1A 23000163 2689153 The histone demethylase is *required* for estrogen dependent [S100A7] gene expression in human breast cancer cells . Positive_regulation S100A7 KDM1A 23000163 2689192 Together , our data suggest that estrogen induced [S100A7] expression *mediated* by the histone demethylase may downregulate breast cancer cell proliferation , implying a potential tumor suppressor-like function for S100A7 . Positive_regulation S100A7 OSM 17372020 1713756 Results from a microarray analysis comparing the gene modulating effects of OSM with those of 33 different cytokines indicate that is a potent keratinocyte activator similar to TNF-alpha , IL-1 , IL-17 , and IL-22 and that it *acts* in synergy with the latter cytokines in the induction of [S100A7] and beta-defensin 2 expression , characteristic of psoriatic skin . Positive_regulation S100A7 PHF21A 23000163 2689149 The histone demethylase is *required* for estrogen dependent [S100A7] gene expression in human breast cancer cells . Positive_regulation S100A7 PHF21A 23000163 2689188 Together , our data suggest that estrogen induced [S100A7] expression *mediated* by the histone demethylase may downregulate breast cancer cell proliferation , implying a potential tumor suppressor-like function for S100A7 . Positive_regulation S100A7 PHF21B 23000163 2689151 The histone demethylase is *required* for estrogen dependent [S100A7] gene expression in human breast cancer cells . Positive_regulation S100A7 PHF21B 23000163 2689190 Together , our data suggest that estrogen induced [S100A7] expression *mediated* by the histone demethylase may downregulate breast cancer cell proliferation , implying a potential tumor suppressor-like function for S100A7 . Positive_regulation S100A7 RCOR1 23000163 2689148 The histone demethylase is *required* for estrogen dependent [S100A7] gene expression in human breast cancer cells . Positive_regulation S100A7 RCOR1 23000163 2689187 Together , our data suggest that estrogen induced [S100A7] expression *mediated* by the histone demethylase may downregulate breast cancer cell proliferation , implying a potential tumor suppressor-like function for S100A7 . Positive_regulation S100A7 RCOR3 23000163 2689152 The histone demethylase is *required* for estrogen dependent [S100A7] gene expression in human breast cancer cells . Positive_regulation S100A7 RCOR3 23000163 2689191 Together , our data suggest that estrogen induced [S100A7] expression *mediated* by the histone demethylase may downregulate breast cancer cell proliferation , implying a potential tumor suppressor-like function for S100A7 . Positive_regulation S100A7 RREB1 23000163 2689145 The histone demethylase is *required* for estrogen dependent [S100A7] gene expression in human breast cancer cells . Positive_regulation S100A7 RREB1 23000163 2689184 Together , our data suggest that estrogen induced [S100A7] expression *mediated* by the histone demethylase may downregulate breast cancer cell proliferation , implying a potential tumor suppressor-like function for S100A7 . Positive_regulation S100A7 SST 19602113 2247611 These results suggest that *increases* the expression of calprotectin and [S100A7] in oral epithelial cells . Positive_regulation S100A7 VEGFA 21551409 2449336 Stimulation with IL-1ß and also strongly *increased* [psoriasin] transcription . Positive_regulation S100A7 ZMYM2 23000163 2689146 The histone demethylase is *required* for estrogen dependent [S100A7] gene expression in human breast cancer cells . Positive_regulation S100A7 ZMYM2 23000163 2689185 Together , our data suggest that estrogen induced [S100A7] expression *mediated* by the histone demethylase may downregulate breast cancer cell proliferation , implying a potential tumor suppressor-like function for S100A7 . Positive_regulation S100A7 ZNF217 23000163 2689147 The histone demethylase is *required* for estrogen dependent [S100A7] gene expression in human breast cancer cells . Positive_regulation S100A7 ZNF217 23000163 2689186 Together , our data suggest that estrogen induced [S100A7] expression *mediated* by the histone demethylase may downregulate breast cancer cell proliferation , implying a potential tumor suppressor-like function for S100A7 . Positive_regulation S100A8 F2R 17507984 1745064 Thus , the interaction not only elicits the junctional and polarity defects but also *promotes* the morphogenetic activity of [CagA] . Positive_regulation S100A8 IL1B 15943814 1415890 [S100A8] mRNA *induction* by FGF-2 and was partially dependent on the mitogen-activated-protein-kinase pathway and dependent on new protein synthesis . Positive_regulation S100A8 IL1B 18786929 1986165 Here , we report that [S100A8/A9] is expressed in breast cancer cell lines and is *up-regulated* by and tumor necrosis factor-alpha in SKBR3 and MCF-7 cells . Positive_regulation S100A8 MAP2K6 17475625 1761394 inhibitors UO126 and PD98059 *inhibited* both [CagA independent and -dependent] MMP-1 secretion , whereas p38 inhibition enhanced MMP-1 secretion and ERK activation , suggesting p38 negative regulation of MMP-1 and ERK . Positive_regulation S100A8 SPHK1 21233411 2409048 These results define a pathway leading to NOX2 activation , in which p38 MAPK mediated [S100A8/A9] translocation is *regulated* by Ca ( 2+ ) store depletion dependent activation . Positive_regulation S100A8 TNF 10779802 687525 IFN-gamma and *regulate* macrophage expression of the chemotactic S100 [protein S100A8] . Positive_regulation S100A8 TNF 11867565 918059 [S100A8/A9] binding to HMEC-1 is *inducible* by lipopolysaccharide and , and in the presence of calcium . Positive_regulation S100A8 TNF 15943814 1415886 Endotoxin ( LPS ) , interferon gamma (IFNgamma) , and TGF-beta did not *induce* the [S100A8] gene in murine fibroblasts whereas FGF-2 induced mRNA maximally after 12 h . Positive_regulation S100A8 TNF 18786929 1986164 Here , we report that [S100A8/A9] is expressed in breast cancer cell lines and is *up-regulated* by interleukin-1beta and in SKBR3 and MCF-7 cells . Positive_regulation S100B ABCA1 23523156 2818699 Luciferase reporter assay was used for [S100B] *induced* promoter regulation . Positive_regulation S100B ALPPL2 9369488 464054 After the treatment , did not *activate* cyclase while S100b activation remained unaffected suggesting that CD-GCAP could not be a modified form of [S100b] . Positive_regulation S100B BDNF 15659231 1364824 Accordingly , [S100beta] was *increased* in primary cultures of pure astrocytes by exogenous . Positive_regulation S100B CA2 11402046 842940 Intracellular and Zn2+ levels *regulate* the alternative cell density dependent secretion of [S100B] in human glioblastoma cells . Positive_regulation S100B CA2 2736040 114574 Spectral studies of the *dependent* interaction of trifluoperazine with [S100b] . Positive_regulation S100B CA2 9232658 445025 We found that [S100B] exists ( > 99 % ) as a non-covalently associated dimer , S100B ( beta beta ) , at 1 nM subunit concentration ( 500 pM dimer ) in the *presence* or absence of saturating levels of , which implies a dissociation constant in the picomolar range or lower . Positive_regulation S100B CA2 9232658 445026 These results demonstrate for the first time that in reducing environments and at physiological concentrations , [S100B] exists as dimeric S100B ( beta beta ) in the *presence* or absence of , and that the non-covalent dimer is most likely the form of S100B presented to target proteins . Positive_regulation S100B CCL2 22082983 2540797 [S100B] *induced* NF-?B activation and the expression of several proinflammatory genes ( , IL-6 , ICAM-1 ) at mRNA and protein levels in RAGE-A10 , among which MCP-1 expression was the most robust . Positive_regulation S100B CD8A 21447379 2453478 Stimulation of S100B ( + ) CD3 ( + ) ( + ) lymphocytes with anti-CD3 or phytohaemagglutinin *resulted* in release of [S100B] . Positive_regulation S100B CD8B 21447379 2453479 Stimulation of S100B ( + ) CD3 ( + ) ( + ) lymphocytes with anti-CD3 or phytohaemagglutinin *resulted* in release of [S100B] . Positive_regulation S100B ENO2 20694777 2305946 The serum level of increased significantly and the level of [S100beta] *increased* insignificantly after the tumor resection . Positive_regulation S100B FGF2 9483501 488126 Our results indicate that changes in transcription account for changes in steady state levels of messenger RNA since *induced* changes in [S100 beta] primary transcript temporally preceded changes in messenger RNA . Positive_regulation S100B GCM1 14573516 1158746 In particular , mouse *induced* the expression of astrocyte-specific Ca ( 2+ ) -binding protein , [S100beta] , in those cells . Positive_regulation S100B GRM3 10457374 639321 Activation of A ( 1 ) adenosine or metabotropic glutamate receptors *enhances* the release of nerve growth factor and [S-100beta] protein from cultured astrocytes . Positive_regulation S100B GRM3 18945900 1978260 Further pharmacological experiments revealed that [S100B] secretion was critically *dependent* on presynaptic release of neurotransmitter and activation of . Positive_regulation S100B GUCY2D 10529237 654492 The present study shows that the E786D mutation has no effect on the basal catalytic activity of and on its *activation* by GCAP1 and [S100beta] ; Positive_regulation S100B HOXC11 17488478 1739320 Forced expression of alone or both HOXC6 isoform 1 and HOXC11 *induced* the expression of [S100beta] in GOTO cells . Positive_regulation S100B HOXC6 17488478 1739321 Forced expression of HOXC11 alone or both isoform 1 and HOXC11 *induced* the expression of [S100beta] in GOTO cells . Positive_regulation S100B HTR1A 12105110 962867 Activation of <5HT(1A)> receptors *causes* the release of [S-100 beta] , a glial derived growth factor . Positive_regulation S100B HTR1A 12468035 1022525 Astrocytic <5HT(1A)> receptors are *involved* in the plastic phenomena by releasing the astroglial derived neurotrophic factor [S-100beta] . Positive_regulation S100B HTR1A 15571670 1344259 The participation of astroglial S100B trophic factor has been proposed since <5HT1A> activation *leads* to [S100B] release and nanomolar concentration level of this molecule showed pro-survival activity in neuronal cultures . Positive_regulation S100B IFNG 19558426 2142526 LPS + *induced* [S100B] up-regulation was not affected by budesonide , while iNOS expression and NO production were significantly inhibited by both specific anti-RAGE and anti-S100B blocking antibodies . Positive_regulation S100B IL1A 15290893 1278619 *upregulates* betaAPP and [S100B] expression and drives numerous neurodegenerative and self amplifying cascades that support a neuroinflammatory component in the pathogenesis of sporadic and Down syndrome related Alzheimer disease . Positive_regulation S100B IL1A 8892349 392089 To more directly assess this driver potential for IL-1 , we analyzed *induction* of [S100 beta] expression in vivo and in vitro , and of beta-APP expression in vivo . Positive_regulation S100B IL1A 8892349 392091 These results provide evidence that *upregulates* both [S100 beta] and beta-APP expression , in vivo and vitro , and support the idea that overexpression of IL-1 in Alzheimer 's disease drives astrocytic overexpression of S100 beta , favoring the growth of dystrophic neurites necessary for evolution of diffuse amyloid deposits into neuritic beta-amyloid plaques . Positive_regulation S100B IL1B 15659225 1364820 We examined the gene-regulatory events through which [S100B] *induces* expression . Positive_regulation S100B IL1B 19042033 2023197 [S100B] secretion is *stimulated* by in glial cultures and hippocampal slices of rats : Likely involvement of MAPK pathway . Positive_regulation S100B IL1B 19042033 2023198 [S100B] secretion was *induced* by in all preparations , involving MAPK pathway and , apparently , NF-small ka , CyrillicB signaling . Positive_regulation S100B IL1B 19042033 2023200 These results suggest that *induced* [S100B] secretion is a component of the neuroinflammatory response , which would support the involvement of S100B in the genesis of neurodegenerative diseases . Positive_regulation S100B IL6 17254641 1704075 [S100B] *induced* and TNF-alpha secretion was blocked by the use of RAGE siRNA specific for knocking down RAGE expression . Positive_regulation S100B IL6 23246638 2757889 *induced* [S100B] secretion is inhibited by haloperidol and risperidone . Positive_regulation S100B IMPA1 19593677 2122891 IMPA1 is regulated by another calcium binding protein calbindin-D28k (CaB) , since we reported earlier that the CaB levels are reduced in SCA1 PCs , the *activation* of by [S100B] may modulate CaB dependent inositol signaling . Positive_regulation S100B ITIH4 23637989 2779305 Nicotine and were able to significantly *increase* the serum levels of ubiquitin C-terminal hydrolase 1 (UCHL1) ( a new BBB marker ) as well as [S100B] in mice , which are correlated with the changes in cBMECs and EPCs . Positive_regulation S100B KIR3DL1 23142267 2717883 On the other hand , BaCl ( 2 ) induced 4.1 inhibition *caused* a decrease in [S100B] secretion . Positive_regulation S100B MAP2 9751173 533513 [S100beta] also *induced* increased neuronal expression of the microtubule associated protein , an effect that is consistent with trophic effects of S100beta on neurite outgrowth . Positive_regulation S100B MOK 16551628 1555602 Here we report that non-receptor Src tyrosine kinase and the membrane protein caveolin-1 (Cav-1) play a key role in the *activation* of by [S100B] in VSMCs . Positive_regulation S100B MOK 18452184 1938766 Here we show that *induced* secretion of [S100B] requires phosphorylated caveolin1 dependent endocytosis of RAGE . Positive_regulation S100B MOK 18599158 2208584 We show here that : ( 1 ) S100B also stimulates AP-1 transcriptional activity in microglia via *dependent* activation of JNK; (2) [S100B] upregulates IL-1beta and TNF-alpha expression in microglia via RAGE engagement ; Positive_regulation S100B MOK 21098642 2355166 Here , we show that *induced* [S100B] secretion involves the recruitment of S100B in lipid rafts and caveolae . Positive_regulation S100B MOK 23719262 2811568 Although [S100B] expression *induced* in vivo , RAGE ablation in mice did not significantly inhibit TAM infiltration into gliomas , suggesting that other pathways were involved in this process . Positive_regulation S100B MYOG 21130124 2414001 However , myogenin ( + ) myoblasts ( i.e. , myocytes ) and myotubes abundantly express [S100B] likely *induced* by . Positive_regulation S100B NCALD 7887910 299059 These findings suggest that [S100 beta] is one of the target proteins of neurocalcin delta , and the beta complex may be *involved* in Ca ( 2+ ) -signalling in the glial cell . Positive_regulation S100B NFKB1 11705636 879418 Mechanism of glial *activation* by [S100B] : involvement of the transcription factor . Positive_regulation S100B NOS2 19558426 2142522 Exogenous [S100B] *induced* a significant increase in both expression and NO production in controls and UC patients ; Positive_regulation S100B NOS2 8576219 350273 Our data indicate that [S100 beta] can *induce* a potent activation of in astrocytes , an observation that might have relevance to the role of S100 beta in neuropathology . Positive_regulation S100B PGM1 9428666 474289 However , mutation of C84 to serine resulted in calcium independent [S100B] *activation* of and a loss of S100B inhibition of tau phosphorylation by Ca2+/calmodulin dependent protein kinase II . Positive_regulation S100B PGM2 9428666 474290 However , mutation of C84 to serine resulted in calcium independent [S100B] *activation* of and a loss of S100B inhibition of tau phosphorylation by Ca2+/calmodulin dependent protein kinase II . Positive_regulation S100B PGM3 9428666 474291 However , mutation of C84 to serine resulted in calcium independent [S100B] *activation* of and a loss of S100B inhibition of tau phosphorylation by Ca2+/calmodulin dependent protein kinase II . Positive_regulation S100B PGM5 9428666 474292 However , mutation of C84 to serine resulted in calcium independent [S100B] *activation* of and a loss of S100B inhibition of tau phosphorylation by Ca2+/calmodulin dependent protein kinase II . Positive_regulation S100B RELA 11705636 879419 Mechanism of glial *activation* by [S100B] : involvement of the transcription factor . Positive_regulation S100B S100A1 10426548 632945 [S100B] is *detected* in the outer limiting membrane , fine cell processes in the outer nuclear layer and the outer plexiform layer , cell bodies in the inner nuclear layer and the ganglion cell layer , and the inner limiting membrane , whereas has a more discrete distribution . Positive_regulation S100B S100A1 12619862 1065924 is the major isoform in normal heart and [S100B] , normally a brain protein , is *induced* in hypertrophic myocardium and functions as an intrinsic negative modulator of the hypertrophic response . Positive_regulation S100B SRC 18452184 1938767 inhibition *blocks* RAGE recycling , [S100B] secretion , and morphological changes . Positive_regulation S100B ST3GAL4 22475793 2613007 Moreover , ( 3 mg/kg ) *increased* hippocampal [S100B] levels in both groups and SOD/CAT ratio in the sedentary animals . Positive_regulation S100B TEAD4 12388300 1031307 Acting in opposing fashions , TEF-1 transrepressed the [S100B] promoter and *transactivated* the promoter . Positive_regulation S100B TNF 17254641 1704074 [S100B] *induced* IL-6 and secretion was blocked by the use of RAGE siRNA specific for knocking down RAGE expression . Positive_regulation S100B TNF 17327432 1706608 These inhibitory effects may be exerted via inhibition of nuclear factor-kappaB (NF-kappaB) activation , as LR-90 suppressed both [S100b-and] *induced* IkappaB-alpha degradation as well as NF-kappaB promoter transcriptional activity . Positive_regulation S100B TNF 23804363 2901924 S100B upregulated TNF-a and M1 markers in RAW , and *augmented* [S100B] secretion from L1 . Positive_regulation S100B TP53 10490652 645613 Concerted regulation of wild-type nuclear accumulation and *activation* by [S100B] and calcium dependent protein kinase C . Positive_regulation S100B TP53 1454855 205561 Furthermore , and of particular interest , we have shown that purified undergoes temperature dependent oligomerization and that the interaction between [S100b] and p53 not only *induces* total inhibition of p53 oligomerization but also promotes disassembly of the p53 oligomers . Positive_regulation S100B TP53 20351179 2255144 Such a function for S100B might also help to explain the rescue of nuclear translocation and *activation* of the temperature-sensitive mutant by [S100B] at nonpermissive temperatures . Positive_regulation S100B VEGFA 17383127 1735468 HG or [S100b] *induced* an increase in expression of at both mRNA and protein levels ( p < 0.05 ; p < 0.01 versus control ) . Positive_regulation S100B VEGFA 21889514 2539106 In myocytes expressing dominant negative RAGE , [S100B] did not *induce* VEGF mRNA , VEGF protein , secretion or NF-?B activation . Positive_regulation S100G ARSG 24324328 2880247 regulates the expression of CaBP9k and IL-4 receptor genes , and ORZ *regulates* the expression of the [CaBP9k] gene , while GABA at 100 mg/kg regulates the expression of the HSP70 gene . Positive_regulation S100G IL1B 25049477 2718828 Real-time RT-PCR analysis showed that E2 and *increased* [S100G] mRNA levels in the uterine endometrium , and conceptuses expressed S100G mRNA during early pregnancy , as determined by RT-PCR analysis . Positive_regulation S100G IL1B 25049477 2718829 These results showed that [S100G] expression in the uterine endometrium was *regulated* by estrogen and of conceptus origin , and affected by the SCNT procedure during early pregnancy . Positive_regulation S11 FAS 7520296 243632 Striking similarities between HIV-1 Env protein and the apoptosis *mediating* cell [surface antigen] . Positive_regulation S11 FUT4 9376686 465523 Independent regulation of and Fuc-TVII genes *leading* to modulation of cell [surface antigen] expression in developing myeloid cells . Positive_regulation S11 TNF 1325213 195178 Our results indicate that ( 1 ) the type B receptor mediates some responses to TNF in HL-60 and U937 cells , ( 2 ) the type A receptor does not stimulate these responses , ( 3 ) the TNF molecule is not necessary for some of these actions , and ( 4 ) *induced* morphologic changes and [surface antigen] expression in HL-60 cells may be regulated by separate postreceptor pathways . Positive_regulation S11 TNF 7681399 214244 Moreover , induced a moderate *increase* of CD14 [surface antigen] expression , used as a phenotypic marker of monocyte/macrophage differentiation . Positive_regulation S12 FAS 7520296 243633 Striking similarities between HIV-1 Env protein and the apoptosis *mediating* cell [surface antigen] . Positive_regulation S12 FUT4 9376686 465525 Independent regulation of and Fuc-TVII genes *leading* to modulation of cell [surface antigen] expression in developing myeloid cells . Positive_regulation S12 TNF 1325213 195179 Our results indicate that ( 1 ) the type B receptor mediates some responses to TNF in HL-60 and U937 cells , ( 2 ) the type A receptor does not stimulate these responses , ( 3 ) the TNF molecule is not necessary for some of these actions , and ( 4 ) *induced* morphologic changes and [surface antigen] expression in HL-60 cells may be regulated by separate postreceptor pathways . Positive_regulation S12 TNF 7681399 214245 Moreover , *induced* a moderate increase of CD14 [surface antigen] expression , used as a phenotypic marker of monocyte/macrophage differentiation . Positive_regulation S1PR1 F2R 15626732 1387907 Endothelial barrier protection by activated protein C through *dependent* [sphingosine 1-phosphate receptor-1] crossactivation . Positive_regulation S1PR1 F2R 18000237 1826988 Evidence points to a role for activation of the [S1P(1)] receptor that is *induced* by mediated signaling in the mechanism of AJ reannealing and endothelial barrier repair . Positive_regulation S1PR1 RGS16 18046543 1852431 Taken together , our data show that most likely ET ( B ) - and [S1P1-receptors] *induce* protein expression in cardiac myocytes by increasing the transcriptional activity of the rgs16 gene . Positive_regulation S1PR1 S1PR3 22480845 2658454 In diabetes , [S-1-PR1] expression is *enhanced* , while S-1-PR2 and expression are both maintained . Positive_regulation S1PR1 S1PR3 22763095 2676287 The decreased cell apoptosis induced by S1P was abolished after treatment with VPC23019 , an *inhibitor* of [S1P1] and S1P3 receptors , W146 , an inhibitor of S1P1 receptors , and CAY10444 , an inhibitor of receptors . Positive_regulation S1PR1 SNCAIP 12087059 959399 Recent studies have shown that in *response* to , [Edg-1] mediates various signaling pathways through downstream signaling molecules , such as MAP kinase and calcium , via heterotrimeric G-proteins . Positive_regulation S1PR2 HBEGF 10354366 617792 Similar transfection with Edg-3 plus -5 antisense plasmids suppressed Tsup-1 cell levels of immunoreactive [Edg-3 and -5] , but not Edg-2 or -4 , and concurrently reduced S1P- , but not LPA- , *induced* Tsup-1 cell increases in both and susceptibility to DT . Positive_regulation S1PR2 S1PR3 12588974 1059733 Upon inactivation of Gi by pertussis toxin , *mediated* inhibition of Rac and migration just like [S1P2] . Positive_regulation S1PR2 SNCAIP 12667959 1075655 , derived from platelets and dephosphorylated on the cell surface , may *induce* the contraction of coronary artery smooth muscle cells through the [S1P(2)/Rho] signaling . Positive_regulation S1PR2 TNF 23770055 2870601 [Sphingosine-1-phosphate receptor-2] *mediated* NF?B activation contributes to induced VCAM-1 and ICAM-1 expression in endothelial cells . Positive_regulation S1PR3 HBEGF 10354366 617789 Similar transfection with Edg-3 plus -5 antisense plasmids suppressed Tsup-1 cell levels of immunoreactive [Edg-3] and -5 , but not Edg-2 or -4 , and concurrently reduced S1P- , but not LPA- , *induced* Tsup-1 cell increases in both and susceptibility to DT . Positive_regulation S1PR3 HNRNPF 20826749 2325210 Thus , in vitro generated *require* S1P(1) and [S1P(3)] to accomplish this , whereas skin derived DCs migrate unhindered in the absence of S1P(3) but not when S1P(1) signaling is blocked . Positive_regulation S1PR3 HNRNPH1 20826749 2325211 Thus , in vitro generated *require* S1P(1) and [S1P(3)] to accomplish this , whereas skin derived DCs migrate unhindered in the absence of S1P(3) but not when S1P(1) signaling is blocked . Positive_regulation S1PR3 LPA 10354366 617790 Similar transfection with Edg-3 plus -5 antisense plasmids suppressed Tsup-1 cell levels of immunoreactive [Edg-3] and -5 , but not Edg-2 or -4 , and concurrently reduced S1P- , but not , *induced* Tsup-1 cell increases in both HB-EGF and susceptibility to DT . Positive_regulation S1PR3 LPA 18701480 1950421 LPA transactivated the epidermal growth factor receptor (EGFR) in these cells , and the EGFR inhibitor AG1478 attenuated the increased SphK1 and [S1P(3)] expression *induced* by . Positive_regulation S1PR3 MBTPS1 10354366 617788 Similar transfection with Edg-3 plus -5 antisense plasmids suppressed Tsup-1 cell levels of immunoreactive [Edg-3] and -5 , but not Edg-2 or -4 , and concurrently reduced , but not LPA- , *induced* Tsup-1 cell increases in both HB-EGF and susceptibility to DT . Positive_regulation S1PR3 MBTPS1 16956652 1646592 low S1P dose increased S1P1 and decreased S1P2 , while high *increased* [S1P3] . Positive_regulation S1PR3 MBTPS1 18172856 1911114 The type 1 [S1P-R] ( S1P(1) ) is important for lymphocyte egress , and blood-borne as the natural ligand for S1P(1) is *involved* in the maintenance of lymphocyte circulation . Positive_regulation S1PR3 MBTPS1 19776367 2168407 We show that dependent Ca ( 2+ ) elevations do occur in these cells and that they might be *mediated* by S1P1R and [S1P3R] . Positive_regulation S1PR3 MBTPS1 21920544 2584991 mediated VSMC migration is modulated by a G-protein coupled src pathway partially through src mediated p38 ( MAPK ) and JNK signaling and *requires* S-1-PR1 and [S-1-PR3] receptors . Positive_regulation S1PR3 MBTPS1 9409733 471501 When overexpressed in Jurkat cells , H218 and [Edg3] activated serum response element-driven transcriptional reporter gene in *response* to , dihydro-S1P and sphingosylphosphorylcholine , but not to LPA . Positive_regulation S1PR3 MYLK 17006328 1628936 While FTY720-P activated both S1P1 and S1P3 receptors , selectively *activated* S1P1 , but not the [S1P3] receptor ( EC50 : > 1000 nM ) . Positive_regulation S1PR3 PTBP1 20826749 2325212 Thus , in vitro generated *require* S1P(1) and [S1P(3)] to accomplish this , whereas skin derived DCs migrate unhindered in the absence of S1P(3) but not when S1P(1) signaling is blocked . Positive_regulation S1PR3 PTBP2 20826749 2325209 Thus , in vitro generated *require* S1P(1) and [S1P(3)] to accomplish this , whereas skin derived DCs migrate unhindered in the absence of S1P(3) but not when S1P(1) signaling is blocked . Positive_regulation S1PR3 RHO 11150298 795292 Sphingosine 1-phosphate induced endothelial cell migration requires the expression of EDG-1 and [EDG-3] receptors and dependent *activation* of alpha vbeta3- and beta1 containing integrins . Positive_regulation S1PR3 RHOA 17395891 1766221 Morphine , DAMGO , thrombin , and LPS induced *mediated* threonine phosphorylation of [S1P(3)] , which was blocked by MNTX , suggesting S1P(3) transactivation . Positive_regulation S1PR3 ROCK1 17395891 1766219 Morphine , DAMGO , thrombin , and LPS induced *mediated* threonine phosphorylation of [S1P(3)] , which was blocked by MNTX , suggesting S1P(3) transactivation . Positive_regulation S1PR3 ROCK2 17395891 1766220 Morphine , DAMGO , thrombin , and LPS induced *mediated* threonine phosphorylation of [S1P(3)] , which was blocked by MNTX , suggesting S1P(3) transactivation . Positive_regulation S1PR3 S1PR1 18541717 1945785 HLECs expressed S1P1 and [S1P3] , and both RNA interference mediated down-regulation of and an S1P1 antagonist significantly *blocked* S1P mediated lymphangiogenesis . Positive_regulation S1PR3 VEGFA 16527273 1536193 We show that the *stimulates* the expression of [Edg3/S1P3] ( S1P3 ) and that expression of this Gi-protein coupled receptor is both sufficient and necessary for the expression of Akt3 . Positive_regulation S7 FAS 7520296 243634 Striking similarities between HIV-1 Env protein and the apoptosis *mediating* cell [surface antigen] . Positive_regulation S7 FUT4 9376686 465527 Independent regulation of and Fuc-TVII genes *leading* to modulation of cell [surface antigen] expression in developing myeloid cells . Positive_regulation S7 TNF 1325213 195180 Our results indicate that ( 1 ) the type B receptor mediates some responses to TNF in HL-60 and U937 cells , ( 2 ) the type A receptor does not stimulate these responses , ( 3 ) the TNF molecule is not necessary for some of these actions , and ( 4 ) *induced* morphologic changes and [surface antigen] expression in HL-60 cells may be regulated by separate postreceptor pathways . Positive_regulation S7 TNF 7681399 214246 Moreover , induced a moderate *increase* of CD14 [surface antigen] expression , used as a phenotypic marker of monocyte/macrophage differentiation . Positive_regulation SAA1 IL1B 10886778 709863 These findings are in contrast to the results obtained from hepatoma cell line HepG2 , in which alone could *induce* [SAA] secretion , while dexamethasone supplemented FCS could not . Positive_regulation SAA1 IL1B 11160347 781712 In the human experimental system , *induced* transcription of acute-phase [SAA] ( A-SSA ; encoded by SAA1/SAA2 ) in primary chondrocytes . Positive_regulation SAA1 IL1B 11298127 801866 These findings suggest that activation of monocytes by or IFN-gamma hampers the proteolysis of a precursor protein and *leads* to a partial degradation of [SAA] . Positive_regulation SAA1 IL1B 1424289 202238 ( ii ) IL-1 alpha and both *induced* CRP and [SAA] synthesis by HepG2 cells , but only in the presence of IL-6 . Positive_regulation SAA1 IL1B 15695308 1382609 is a most potent *inducer* of [SAA] in normal hepatocytes . Positive_regulation SAA1 IL1B 15695308 1382615 These results indicate that MAPK signalling pathways are critical in *induced* hepatic [SAA] synthesis . Positive_regulation SAA1 IL1B 16483749 1534803 [SAA] *induced* dose dependent production of TNF-alpha and in HMC-1 cells . Positive_regulation SAA1 IL1B 18240213 1871404 and TNFalpha *caused* increased release of chitinase 3-like protein 1 (CHI3L1) , CHI3L2 , complement factor B , matrix metalloproteinase 3 , ECM-1 , haptoglobin , [serum amyloid A3] , and clusterin . Positive_regulation SAA1 IL1B 19026124 1992384 Amyloid development in familial Mediterranean fever ( FMF ) patients is associated with acute phase response and the acute phase reactant [serum amyloid A] which is *induced* by . Positive_regulation SAA1 IL1B 19223523 2071992 , TNF-alpha , and human AT macrophage conditioned medium significantly *induced* [A-SAA] secretion ( from 2.6 to 7.6 fold ) in hMADS cells . Positive_regulation SAA1 IL1B 2454996 93463 These results indicate that human [SAA] and CRP are *induced* in Hep 3B cells by products of activated monocytes but not by , TNF-alpha , or some hepatocyte stimulating factor preparations and that a group of heterogeneous mechanisms are involved in the induction of the various human APP . Positive_regulation SAA1 IL1B 7814886 292808 *Induction* of human [serum amyloid A] in Hep 3B cells by IL-6 and involves both transcriptional and post-transcriptional mechanisms . Positive_regulation SAA1 IL1B 8387777 218068 These data provide evidence of a paradox with regard to the transcriptional *upregulation* of [A-SAA] by + IL-6 and the relative synthesis of A-SAA protein and suggest a role for post-transcriptional control of A-SAA biosynthesis during the acute phase . Positive_regulation SAA1 IL1B 9256609 448377 *induced* both CRP and [SAA] production but only in the co-presence of IL-6 . Positive_regulation SAA1 IL1B 9359864 462277 The ability of C2 and C6 to potentiate the effects of cytokines suggests that the sphingomyelin-ceramide pathway participates in *induction* of CRP and [SAA] by under these experimental conditions , most likely by transducing the effects of IL-1beta . Positive_regulation SAA1 SELL 20201074 2265374 Recombinant [SAA] potently *induced* cleavage of from neutrophils and in whole blood samples . Positive_regulation SAA1 TLR7 20813127 2363634 Salmonid Tollip and MyD88 factors can functionally replace their mammalian orthologues in mediated trout [SAA] promoter *activation* . Positive_regulation SAA1 TLR7 20813127 2363644 Overexpression of a transdominant negative mutant of the trout MyD88 factor reduced mediated [SAA] promoter *activation* confirming functional conservation of its TIR domain . Positive_regulation SAA1 TNF 10831790 697621 [Serum amyloid A] transcription in Atlantic salmon ( Salmo salar L. ) hepatocytes is enhanced by *stimulation* with macrophage factors , recombinant human IL-1 beta , IL-6 and or bacterial lipopolysaccharide . Positive_regulation SAA1 TNF 12557750 1029072 The [Saa1] and Saa2 promoters are strongly *induced* by IL-6 , with synergistic upregulation of Saa2 , but not of Saa1 , by IL-1 or . Positive_regulation SAA1 TNF 1424289 202243 ( iv ) in the presence or absence of IL-6 and/or prednisolone did not *induce* the production of [SAA] or CRP by HepG2 cells . Positive_regulation SAA1 TNF 14749357 1226339 *induces* [serum amyloid A3] in mouse granulosa cells . Positive_regulation SAA1 TNF 14871291 1208137 The *induction* of [SAA1] , but not that of SAA2 , can be enhanced by GCs in both cell lines , whereas GCs alone can upregulate SAA1 only in epithelial cells . Positive_regulation SAA1 TNF 16483749 1534802 [SAA] *induced* dose dependent production of and IL-1 beta in HMC-1 cells . Positive_regulation SAA1 TNF 1651357 163080 alone had no significant effect on synthesis of either SAA or CRP , but the combination of IL-6 plus TNF-alpha *led* to substantial induction of [SAA] . Positive_regulation SAA1 TNF 18175929 1856172 treatment of HC11 cells also *induced* expression of [SAA] genes , and the effect on SAA1 and SAA2 expression was suppressed by treatment with MG132 , and in cells transfected with a dominant negative mutant form of IkappaBalpha . Positive_regulation SAA1 TNF 18240213 1871403 IL-1beta and *caused* increased release of chitinase 3-like protein 1 (CHI3L1) , CHI3L2 , complement factor B , matrix metalloproteinase 3 , ECM-1 , haptoglobin , [serum amyloid A3] , and clusterin . Positive_regulation SAA1 TNF 18571179 2019868 Unlike CRP , [SAA] *induced* TF and in THP-1 cells . Positive_regulation SAA1 TNF 19223523 2071991 IL-1beta , , and human AT macrophage conditioned medium significantly *induced* [A-SAA] secretion ( from 2.6 to 7.6 fold ) in hMADS cells . Positive_regulation SAA1 TNF 19483409 2085964 The results , indicated that the IL-6 signal was essential though the activation of STAT3 for the *induction* and augmentation of CRP or [SAA] by the associated stimulation with or IL-1 . Positive_regulation SAA1 TNF 20444945 2275052 Because ovulation is an inflammatory reaction and specifically *induces* [serum amyloid A3 (SAA3)] in mouse granulosa cells , the effect of cAMP on TNF induced SAA3 promoter activity , mRNA and protein was investigated . Positive_regulation SAA1 TNF 20732231 243059 LPS and *increased* the secretion of [serum amyloid A (SAA)] in hamster hepatocytes . Positive_regulation SAA1 TNF 2454996 93462 These results indicate that human [SAA] and CRP are *induced* in Hep 3B cells by products of activated monocytes but not by IL-1 beta , , or some hepatocyte stimulating factor preparations and that a group of heterogeneous mechanisms are involved in the induction of the various human APP . Positive_regulation SAA1 TNF 3261378 96035 Dexamethasone modulation of LPS , IL-1 , and *stimulated* [serum amyloid A] synthesis in mice . Positive_regulation SAA1 TNF 3261378 96041 Exogenous IL-1 and *induce* [SAA] synthesis in vivo and in vitro , while exogenous IL-6 is a far less potent stimulus of in vivo SAA gene expression . Positive_regulation SAA1 TNF 3261378 96045 However , DEX did not reduce , but rather potentiated , IL-1 and *stimulated* [SAA] production , indicating that these monokines do not require macrophage products to mediate their in vivo SAA inducer activity . Positive_regulation SAA1 TNF 3495710 73706 is a less potent *inducer* of [serum amyloid A] synthesis than interleukin 1 . Positive_regulation SAA2 IL1B 10219766 609111 Using HepG2 hepatoma cells transfected with pGL2-SAA2pt , a cytokine-responsive human SAA2 promoter/luciferase reporter gene construct , we show that stimulation with prior to IL-6 is *essential* for maximal synergistic transcriptional induction of the [SAA2] gene . Positive_regulation SAA2 IL1B 10219766 609112 The reciprocal treatment , i.e. stimulation of the promoter with IL-6 before *results* in significantly less synergistic activation of the [SAA2] promoter . Positive_regulation SAA2 IL1B 15812237 1392228 Therefore , these results suggest that NaBu and *mediate* [SAA2] synergistic induction by establishing and maintaining similar and complementary chromatin modifications and transcription factor recruitment as well . Positive_regulation SAA2 IL1B 18240213 1871406 and TNFalpha *caused* increased release of chitinase 3-like protein 1 (CHI3L1) , CHI3L2 , complement factor B , matrix metalloproteinase 3 , ECM-1 , haptoglobin , [serum amyloid A3] , and clusterin . Positive_regulation SAA2 IL1B 19026124 1992385 Amyloid development in familial Mediterranean fever ( FMF ) patients is associated with acute phase response and the acute phase reactant [serum amyloid A] which is *induced* by . Positive_regulation SAA2 IL1B 7814886 292810 *Induction* of human [serum amyloid A] in Hep 3B cells by IL-6 and involves both transcriptional and post-transcriptional mechanisms . Positive_regulation SAA2 TNF 10831790 697623 [Serum amyloid A] transcription in Atlantic salmon ( Salmo salar L. ) hepatocytes is enhanced by *stimulation* with macrophage factors , recombinant human IL-1 beta , IL-6 and or bacterial lipopolysaccharide . Positive_regulation SAA2 TNF 12557750 1029075 The Saa1 and [Saa2] promoters are strongly *induced* by IL-6 , with synergistic upregulation of Saa2 , but not of Saa1 , by IL-1 or . Positive_regulation SAA2 TNF 14749357 1226340 *induces* [serum amyloid A3] in mouse granulosa cells . Positive_regulation SAA2 TNF 18240213 1871405 IL-1beta and *caused* increased release of chitinase 3-like protein 1 (CHI3L1) , CHI3L2 , complement factor B , matrix metalloproteinase 3 , ECM-1 , haptoglobin , [serum amyloid A3] , and clusterin . Positive_regulation SAA2 TNF 3261378 96037 Dexamethasone modulation of LPS , IL-1 , and *stimulated* [serum amyloid A] synthesis in mice . Positive_regulation SAA2 TNF 3495710 73707 Tumor necrosis is a less potent *inducer* of [serum amyloid A] synthesis than interleukin 1 . Positive_regulation SAA2 TNF 8565321 349116 IL-1 and *induced* hepatic accumulation of both SAA1 , [SAA2] and SAA3 , while only SAA1 and SAA2 mRNA accumulation was seen after IL-6 stimulation . Positive_regulation SAA3P IL1B 18452164 1938760 The adipokine [SAA3] is *induced* by in mouse adipocytes . Positive_regulation SAA3P IL1B 18452164 1938762 Furthermore , significantly *induced* [SAA3] mRNA expression dose-dependently with maximal 36.4-fold upregulation seen at 2 ng/ml effector . Positive_regulation SAA3P IL1B 18452164 1938764 Moreover , *induced* [SAA3] expression was mediated by nuclear factor-kappaB and janus kinase 2 . Positive_regulation SAA3P IL1B 18452164 1938765 Taken together , our data show a potent *upregulation* of [SAA3] by . Positive_regulation SAA3P TLR7 21335610 2443376 TAK1 inhibition abrogated cytokine- and induced nuclear factor-?B ( NF-?B ) and [Saa3-promoter] reporter *activation* in murine and human dermal fibroblasts . Positive_regulation SAA3P TNF 14749357 1226348 Overexpression of the inhibitor of NF-kappaB ( called IkappaB ) blocked [SAA3] promoter activity *induced* by and by p65 in OV3121-1 cells . Positive_regulation SAA3P TNF 14749357 1226350 also *increased* phospho-IkB and [SAA3] in whole-cell homogenates as determined by Western blots . Positive_regulation SAA3P TNF 14749357 1226351 Thus , likely *increased* [SAA3] promoter activity and protein by activating NF-kappaB signaling via TNFR1 in mouse granulosa cells . Positive_regulation SAA3P TNF 20444945 2275053 Because ovulation is an inflammatory reaction and TNF specifically induces serum amyloid A3 (SAA3) in mouse granulosa cells , the effect of cAMP on *induced* [SAA3] promoter activity , mRNA and protein was investigated . Positive_regulation SAA3P TNF 20444945 2275054 *increased* [SAA3] promoter activity , mRNA , and protein , which were further increased by cAMP . Positive_regulation SAA3P TNF 20444945 2275055 Thus , there appeared to be different mechanisms by which and cAMP *regulated* [SAA3] expression . Positive_regulation SAA3P TNF 20444945 2275057 Among four CCAAT enhancing binding protein (C/EBP) sites in the SAA3 promoter , the C/EBP site nearest the NF-kappaB-like site was required for *induced* [SAA3] . Positive_regulation SAA3P TNF 21335610 2443381 In synovial fibroblasts , TAK1 regulated IL-1 and *mediated* NF-?B , but not [Saa3-promoter] reporter activation . Positive_regulation SAA3P TNF 8565321 349118 IL-1 and *induced* hepatic accumulation of both SAA1 , SAA2 and [SAA3] , while only SAA1 and SAA2 mRNA accumulation was seen after IL-6 stimulation . Positive_regulation SAA4 IL1B 18240213 1871408 and TNFalpha *caused* increased release of chitinase 3-like protein 1 (CHI3L1) , CHI3L2 , complement factor B , matrix metalloproteinase 3 , ECM-1 , haptoglobin , [serum amyloid A3] , and clusterin . Positive_regulation SAA4 IL1B 19026124 1992386 Amyloid development in familial Mediterranean fever ( FMF ) patients is associated with acute phase response and the acute phase reactant [serum amyloid A] which is *induced* by . Positive_regulation SAA4 IL1B 7814886 292812 *Induction* of human [serum amyloid A] in Hep 3B cells by IL-6 and involves both transcriptional and post-transcriptional mechanisms . Positive_regulation SAA4 TNF 10831790 697625 [Serum amyloid A] transcription in Atlantic salmon ( Salmo salar L. ) hepatocytes is enhanced by *stimulation* with macrophage factors , recombinant human IL-1 beta , IL-6 and or bacterial lipopolysaccharide . Positive_regulation SAA4 TNF 14749357 1226341 *induces* [serum amyloid A3] in mouse granulosa cells . Positive_regulation SAA4 TNF 18240213 1871407 IL-1beta and *caused* increased release of chitinase 3-like protein 1 (CHI3L1) , CHI3L2 , complement factor B , matrix metalloproteinase 3 , ECM-1 , haptoglobin , [serum amyloid A3] , and clusterin . Positive_regulation SAA4 TNF 3261378 96039 Dexamethasone modulation of LPS , IL-1 , and *stimulated* [serum amyloid A] synthesis in mice . Positive_regulation SAA4 TNF 3495710 73708 is a less potent *inducer* of [serum amyloid A] synthesis than interleukin 1 . Positive_regulation SAFB ETV7 21950761 2502548 BRCA1 was found to enhance [SAFB] protein expression and *induce* nuclear translocation . Positive_regulation SAG TNF 18685727 1949260 [S-Ag] peptides significantly *induced* a production of IFN-gamma and but not interleukin (IL)-2 , IL-4 , and IL-17 by peripheral blood mononuclear cells ( PBMCs ) in active BD patients with a response to S-Ag . Positive_regulation SAP130 CAPN8 17986223 1850793 Interestingly , [SAP] did not *induce* caspase and activation , suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways . Positive_regulation SAP130 TNF 10788429 688666 Acute phorbol 12-myristate 13-acetate pretreatment also inhibited *stimulated* [SAP] kinase activity , while chronic pretreatment reversed the effects of UTP . Positive_regulation SAP30 CAPN8 17986223 1850496 Interestingly , [SAP] did not *induce* caspase and activation , suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways . Positive_regulation SAP30 TNF 10788429 688663 Acute phorbol 12-myristate 13-acetate pretreatment also inhibited *stimulated* [SAP] kinase activity , while chronic pretreatment reversed the effects of UTP . Positive_regulation SARM1 MAVS 23499490 2771993 Activation of the innate signaling molecule by bunyavirus infection *upregulates* the adaptor protein [SARM1] , leading to neuronal death . Positive_regulation SAT1 IL1B 10852253 701606 An increase in the putrescine level in rheumatoid synovial adherent cells as a result of the elevation of [SAT] activity *induced* by may play a role in RA . Positive_regulation SAT1 TNF 16757480 1599106 Stable overexpression of a mutant , dominant negative IkappaBalpha protein led to the suppression of [SSAT] *induction* by in these cells , thereby substantiating a role of NFkappaB in the induction of SSAT by TNFalpha . Positive_regulation SAT1 TNF 16757480 1599111 Electromobility shift assays , chromatin immunoprecipitation experiments and mutational studies confirmed that two of the three NFkappaB response elements play an important role in the regulation of [SSAT] in *response* to . Positive_regulation SBF1 TNF 15763366 1383375 We found that [SBF] ( 0.05-0.25 mg/ml ) slightly *induced* , IL-6 , NO ( nitric oxide ) and PGE2 ( prostaglandin E2 ) production in unstimualted murine macrophages , RAW264.7 cells . Positive_regulation SBF2 TNF 15763366 1383379 We found that [SBF] ( 0.05-0.25 mg/ml ) slightly *induced* , IL-6 , NO ( nitric oxide ) and PGE2 ( prostaglandin E2 ) production in unstimualted murine macrophages , RAW264.7 cells . Positive_regulation SCAP TNF 17963605 1820267 *upregulates* the expression of [SCAP] and promotes the synthesis of triglyceride ; Positive_regulation SCARA3 CD14 14521944 1148218 Activation of signaling pathways by putative [scavenger receptor class A (SR-A)] ligands *requires* but not SR-A . Positive_regulation SCARA3 CPSF3 18806823 2021201 The interaction between [CSR1] and CPSF3 *induced* translocation from the nucleus to the cytoplasm , resulting in inhibition of polyadenylation both in vitro and in vivo . Positive_regulation SCARA3 TLR2 19521507 2092875 MARCO was used preferentially over the highly homologous [scavenger receptor class A (SRA)] , which *required* and TLR4 , as well as their respective accessory molecules , in order for a slight increase in NF-kappaB signaling to occur . Positive_regulation SCARA3 TLR4 19521507 2092876 MARCO was used preferentially over the highly homologous [scavenger receptor class A (SRA)] , which *required* TLR2 and , as well as their respective accessory molecules , in order for a slight increase in NF-kappaB signaling to occur . Positive_regulation SCARA5 CD14 14521944 1148219 Activation of signaling pathways by putative [scavenger receptor class A (SR-A)] ligands *requires* but not SR-A . Positive_regulation SCARB1 PDZK1 18174467 1869949 Thus , is uniquely *required* for [HDL/SR-BI] signaling in endothelium , and through these mechanisms , it is critically involved in the maintenance of endothelial monolayer integrity . Positive_regulation SCD ADRB2 16618831 1551207 Sympathetic activation influences the risk of ventricular arrhythmias and [sudden cardiac death (SCD)] , *mediated* in part by the . Positive_regulation SCG2 TNF 15087472 1258122 and IL-1 induced a time- and dose dependent *increase* in galanin , vasoactive intestinal polypeptide , and [secretogranin II] mRNA levels . Positive_regulation SCGB1A1 TNF 22830293 2635410 The addition of FEX into cell cultures caused increase in [CC10] production *induced* by stimulation , and the minimum concentration that caused significant increase was 200 ng/ml. Oral administration of FEX also increased CC10 levels in nasal secretions from pollinosis patients along with attenuation of clinical symptoms . Positive_regulation SCGB3A1 EGF 15811345 1392185 *Induction* of [Ugrp2] mRNA expression by and transforming growth factor alpha was examined using mouse transformed lung Clara cell derived mtCC cells . Positive_regulation SCGB3A1 EGF 15811345 1392186 The *induced* increase of [Ugrp2] occurred at the transcriptional level that required the EGF receptor and the activation of the ERK-MAPK and phosphoinositide-3 kinase pathways . Positive_regulation SCGB3A1 IL13 16237061 1470741 Addition of actinomycin D abrogated the IL-4- and *induced* increase of [Ugrp2] expression , demonstrating that this increase occurs at the transcriptional level . Positive_regulation SCGB3A1 IL13 16237061 1470749 These results indicate that [Ugrp2] expression is *enhanced* by IL-4 and through STAT6 binding to the proximal SBE located in the Ugrp2 gene promoter . Positive_regulation SCGB3A1 IL4 16237061 1470746 Mutations of the proximal SBE abrogated the binding of activated STAT6 to this site and the *induced* increase in [Ugrp2] gene promoter activity . Positive_regulation SCGB3A1 IL4 16237061 1470748 Furthermore , an *induced* increase in [Ugrp2] expression was not observed in primary cultures of lung cells derived from STAT6-deficient mice . Positive_regulation SCGB3A1 IL4 16237061 1470750 These results indicate that [Ugrp2] expression is *enhanced* by and IL-13 through STAT6 binding to the proximal SBE located in the Ugrp2 gene promoter . Positive_regulation SCGB3A1 NFYA 18194566 1876246 By reporter gene transfection and gel mobility shift analyses , we demonstrated that expression of the mouse [Scgb3a1] gene is *regulated* by a PU-box binding protein and a ubiquitous transcription factor that respectively binds to the PU-boxes located at -99 to -105 bp and -158 to -164 bp , and the `` CCAAT '' binding sites located at -425 to -429 bp and -498 to -502 bp from the transcription start site of the gene . Positive_regulation SCGB3A1 NFYA 18194566 1876252 A ubiquitous transcription factor binds to and *activates* expression of the mouse [Scgb3a1] gene and tissue-specific expression of the gene is associated with CpG methylation of the promoter . Positive_regulation SCGB3A1 NFYB 18194566 1876247 By reporter gene transfection and gel mobility shift analyses , we demonstrated that expression of the mouse [Scgb3a1] gene is *regulated* by a PU-box binding protein and a ubiquitous transcription factor that respectively binds to the PU-boxes located at -99 to -105 bp and -158 to -164 bp , and the `` CCAAT '' binding sites located at -425 to -429 bp and -498 to -502 bp from the transcription start site of the gene . Positive_regulation SCGB3A1 NFYB 18194566 1876253 A ubiquitous transcription factor binds to and *activates* expression of the mouse [Scgb3a1] gene and tissue-specific expression of the gene is associated with CpG methylation of the promoter . Positive_regulation SCGB3A1 NFYC 18194566 1876248 By reporter gene transfection and gel mobility shift analyses , we demonstrated that expression of the mouse [Scgb3a1] gene is *regulated* by a PU-box binding protein and a ubiquitous transcription factor that respectively binds to the PU-boxes located at -99 to -105 bp and -158 to -164 bp , and the `` CCAAT '' binding sites located at -425 to -429 bp and -498 to -502 bp from the transcription start site of the gene . Positive_regulation SCGB3A1 NFYC 18194566 1876254 A ubiquitous transcription factor binds to and *activates* expression of the mouse [Scgb3a1] gene and tissue-specific expression of the gene is associated with CpG methylation of the promoter . Positive_regulation SCGB3A1 OSM 18978304 2053305 Here we show that the expression of [SCGB3A1] and SCGB3A2 are bidirectionally *regulated* by when examined in a mouse transformed Clara cell line ( mtCC ) ; Positive_regulation SCGB3A1 OSM 18978304 2053309 [SCGB3A1] is *up-regulated* by , while SCGB3A2 is down-regulated in a time- and dose dependent manner . Positive_regulation SCGB3A1 OSM 18978304 2053310 OSM activated STAT3/5 , through binding to the STAT binding element located at -201 to -209 bp in the mouse Scgb3a1 gene promoter , and the extracellular signal regulated kinase ( ERK ) - and p38-mitogen activated protein kinase (MAPK) pathways are responsible for the induced *up-regulation* of [SCGB3A1] expression . Positive_regulation SCGB3A1 TGFA 15811345 1392184 *Induction* of [Ugrp2] mRNA expression by epidermal growth factor (EGF) and was examined using mouse transformed lung Clara cell derived mtCC cells . Positive_regulation SCGB3A2 SCGB3A1 12175512 976866 Highest HIN-1 and [UGRP-1] expression is *detected* in the lung , while lower level expression is also detected in the stomach , heart , small intestine , uterine and mammary glands . Positive_regulation SCIN AHR 11883943 919745 Here , by using chimeric mice with TCDD-responsive ( AhR ( +/+ ) ) hematopoietic cells and TCDD-unresponsive ( AhR ( minus sign/minus sign ) ) thymic stroma , or the reverse , we show that TCDD induced expression of [adseverin] in thymus is *dependent* on expression in hematopoietic cells but not in stroma . Positive_regulation SCIN CA2 1331119 200268 *Activation* of [scinderin] by may cause disassembly of actin filaments leaving cortical areas of low cytoplasmic viscosity which are the sites of exocytosis ( Vitale , M. L. , A. Rodríguez Del Castillo , L. Tchakarov , and J.-M . Positive_regulation SCIN IL9 9671468 519921 Murine [adseverin] ( D5 ) , a novel member of the gelsolin family , and murine adseverin are *induced* by in T-helper lymphocytes . Positive_regulation SCNN1A EPHB2 10722699 677185 Consistent with our hypothesis , exogenous H ( 2 ) O ( 2 ) -mediated repression of [alpha-ENaC] GRE activity is partially *blocked* by either a specific inhibitor for extracellular signal regulated kinase ( ERK ) pathway activation , U0126 , or dominant negative , suggesting that , in part , activated ERK may mediate the repressive effects of H ( 2 ) O ( 2 ) on alpha-ENaC expression . Positive_regulation SCNN1A IL1B 19136575 2037705 [alpha-ENaC] was *induced* by at GD61 and increased late during gestation . Positive_regulation SCRIB EPHB2 20622900 2321780 We also show that hScrib interacts with ERK through two well conserved kinase interaction motif ( KIM ) docking sites , both of which are also required for *induced* phosphorylation of [hScrib] on two distinct residues . Positive_regulation SDC1 IL1B 12824007 1104358 Stimulation of HT29 cells with TNF-alpha and *resulted* in reversible down-regulation of [syndecan-1] at both protein and mRNA levels but little effect was observed with IL-6 . Positive_regulation SDC1 TNF 12824007 1104357 Stimulation of HT29 cells with and IL-1beta *resulted* in reversible down-regulation of [syndecan-1] at both protein and mRNA levels but little effect was observed with IL-6 . Positive_regulation SDC1 TNF 23511033 2761209 Recombinant HPA incubation increased soluble [SDC1] in culture supernatants ( P = 2 × 10 ( -4 ) ) , and low-dose effectively *enhanced* HPA 's activity ( P = 3 × 10 ( -6 ) ) . Positive_regulation SDC2 IL1B 12200971 982988 In contrast , [syndecan-2] mRNA level was markedly upregulated in *response* to either TGF-beta 1 or in OB when compared with the other two cell lines . Positive_regulation SDC2 IL1B 12200971 982991 However , the stimulatory effect of TGF-beta 1 on [syndecan-2] mRNA production in OB was abolished in the prolonged *presence* of . Positive_regulation SDC2 TNF 12840601 1113860 We examined whether IL-8 and *regulated* BM [HSPG] gene expression and HS synthesis in the glomerular epithelial cells ( GECs ) . Positive_regulation SDC4 SPHK1 14705951 1196283 As [syndecan-4] signaling in leukocyte chemotaxis *involves* activation of , results indicate that naloxone interacts with syndecan-4 function in cell migration and suggest a role for heparan sulfate proteoglycans as coreceptors to members of the delta-opiate receptor family . Positive_regulation SDC4 TNF 17545042 1751930 The expression of [syndecan-4] protein was significantly *enhanced* by . Positive_regulation SDC4 TNF 20501378 2263817 The expression of syndecan-4 protein in the VSMCs was significantly enhanced by 20 ng/ml TNF-alpha ( P < 0.01 ) . Pravastatin alone did not affect the expression of syndecan-4 protein ( P > 0.05 ) , but significantly inhibited *induced* enhancement of [syndecan-4] protein expression ( P < 0.01 ) . Positive_regulation SDC4 TNF 23576453 2799861 Molecular mechanisms of [syndecan-4] *upregulation* by in the endothelium-like EAhy926 cells . Positive_regulation SDC4 TNF 23576453 2799862 To elucidate these mechanisms in detail , we examined [syndecan-4] *upregulation* by in the endothelium-like EAhy926 cell . Positive_regulation SDHB TNF 1943475 170715 In contrast , does not *activate* [SDH] in TNF resistant variants derived from U937 and WEHI-164 . Positive_regulation SDHC TNF 1943475 170711 *induces* activation of mitochondrial [succinate dehydrogenase] . Positive_regulation SDHD TNF 11355520 815427 [PGL-I] alone did not *induce* secretion by PBMC , but when associated with a sub-optimal dose of armadillo derived M. leprae increased the release of this cytokine . Positive_regulation SDHD TNF 1943475 170712 *induces* activation of mitochondrial [succinate dehydrogenase] . Positive_regulation SDPR FHL1 18422756 1915234 In addition , global expression analysis indicates that *induced* expression of [serum deprivation response factor (Sdpr)] in Src transformed cells . Positive_regulation SDPR FHL1 18422756 1915249 *induced* the expression of [Sdpr] in Src transformed cells ; Positive_regulation SDS CST6 10795313 689663 It is most likely that in vitro activation of the protease complex by [SDS] is *caused* by the release of bound . Positive_regulation SEA FAS 12373453 996543 When Fas-deficient ( C57BL/6 lpr/lpr ) or Fas ligand defective ( C57BL/6 gld/gld ) mice were treated with TCDD , they failed to exhibit a decrease in percentage and cellularity of SEA-reactive T cells , thereby suggesting a *role* of ligand interactions in the TCDD induced downregulation of [SEA-reactive] T cell response . Positive_regulation SEA TNF 8145023 252593 However , only [SEA] *induced* increased mRNA levels . Positive_regulation SEA TNF 8687436 370429 A synthetic peptide of this region , SEA ( 121-149 ) , blocks [SEA] binding to class II MHC molecules and *induces* interleukin-1 and production in monocytes . Positive_regulation SEA TNF 8806793 382664 The results of this study indicate that [SEA] *induces* the secretion of IL-1 alpha and by epidermal cells , that these cytokines induce LC depletion from epidermis , and that antibodies specific for these agents inhibit the depletion of LC by SEA . Positive_regulation SEC14L2 PRODH 23861960 2817423 We established that over-expression of [TAp73ß] or TAp63ß is sufficient to induce PRODH expression in p53-null cells and that expression *parallels* the modulation of endogenous p73 by genotoxic drugs in several cell lines . Positive_regulation SEC61B EPHB2 10648884 662336 [Membrane] depolarization *induced* calcium increases activated both and p38 kinase within 5 min . Positive_regulation SEC61B TNF 12606436 1064561 [Membrane] type-1 MMP mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation SEH1L NES 9371762 466118 A functional is *required* for active export , presumably by interacting directly or indirectly with the [nuclear pore complex] . Positive_regulation SELE CD14 8751905 377221 With Escherichia coli LPS , tumor necrosis factor alpha activation requires membrane bound and [E-selectin] expression *requires* soluble CD14 ( sCD14 ) . Positive_regulation SELE EPHB2 16715142 1631453 On the other hand , the *activation* of by [E-selectin] modulates the opening of interendothelial spaces by initiating the activation of Src kinase activities and the dissociation of the VE-cadherin/beta-catenin complex . Positive_regulation SELE F2R 11458449 838362 Thrombin and agonist peptide *induced* endothelial leukocyte adhesion molecule-1 ( [ELAM-1] ) expression . Positive_regulation SELE F2R 11458449 838374 Baicalein isolated from Scutellariae Radix inhibited [ELAM-1] expression *induced* by thrombin and agonist peptide dose-dependently , with 50 % inhibitory concentrations ( IC50 ) of 5.53 +/- 1.68 microM and 2.44 +/- 1.08 microM , respectively . Positive_regulation SELE FUT4 10894166 711508 P-selectin ligands generated by FucT-VII are crucial for initial leukocyte tethering , whereas [E-selectin] ligands that permit maximum slowing of Vroll *require* simultaneous expression of and FucT-VII . Positive_regulation SELE FUT4 15579466 1368531 Here we have examined the *role* of human and -VII in conferring L-selectin , P-selectin , and [E-selectin] binding activities to PSGL-1 . Positive_regulation SELE FUT4 7689830 228521 The ELAM ligand , ELFT , *directs* [E-selectin] binding to a secreted scaffold protein : a method to produce and purify large quantities of specific carbohydrate structures . Positive_regulation SELE HBEGF 10210777 607669 Thus physiologically , transient destruction of LN and expression of VCAM-1 , [E-selectin] and fibronectin at sites of inflammation , may locally *induce* overexpression . Positive_regulation SELE IL1B 10559516 566636 Enrichment of HAEC with the same doses of vitamin E suppressed *stimulated* expression of intercellular adhesion molecule-1 ( ICAM-1 ) , vascular cell adhesion molecule-1 ( VCAM-1 ) , and endothelial leukocyte adhesion molecule-1 ( [E-selectin] ) . Positive_regulation SELE IL1B 10580548 570084 Induction of intercellular adhesion molecule ( ICAM-1 ) , vascular cell adhesion molecule ( VCAM-1 ) and E-selectin by TNF-alpha , measured by a radiometric technique , was similar in IVEC and HUVEC , while the *induction* of [E-selectin] by on IVEC was limited and significantly different from that observed on HUVEC ( p < 0.001 ) . Positive_regulation SELE IL1B 10886302 709680 The expression of [E-selectin] and VCAM-1 , which are not constitutively expressed on the cell lines , can be *induced* by stimulation of the endothelial cells with . Positive_regulation SELE IL1B 11403206 824942 At 4 h ICAM-1 and [E-selectin] , but not VACM-1 , were *stimulated* by both and TNF-alpha . Positive_regulation SELE IL1B 11403206 824949 ICAM-1 , VCAM-1 , and [E-selectin] expression were all *stimulated* by both and TNF-alpha in the 24 h assays . Positive_regulation SELE IL1B 11867074 917988 *induced* higher [E-selectin] mRNA levels than TNF-alpha . Positive_regulation SELE IL1B 12107048 962999 NHE inhibition decreased also the IL-1beta induced HUVEC inflammatory response , because amiloride suppressed *induced* [E-selectin] expression on HUVECs . Positive_regulation SELE IL1B 12121710 965082 Effects of estrogen , progesterone , and combination exposure on *induced* expression of VCAM-1 , ICAM-1 , PECAM , and [E-selectin] by human female iliac artery endothelial cells . Positive_regulation SELE IL1B 12239089 989290 The activities of ERalpha and ERbeta were compared in three distinct gene regulatory pathways , including inhibition of *induction* of [E-selectin] expression , inhibition of basal endothelin-1 production , and the ability to induce two matrix stabilizing enzymes : tissue transglutaminase and a novel member of the lysyl oxidase family . Positive_regulation SELE IL1B 12428246 1014854 MSU crystals induced TNFalpha , , and IL-6 ( but not IL-10 ) secretion in undifferentiated monocytes , which in turn *promoted* endothelial cell [E-selectin] expression and secondary neutrophil capture under shear flow . Positive_regulation SELE IL1B 14505317 1144690 We have successfully applied the assays to evaluate ( a ) *activation* of [E-selectin] ( CD62E ) expression by in human umbilical vein endothelial cells ( HUVECs ) , ( b ) induction of CD3 by phorbol-12-myristate-13-acetate in freshly prepared human peripheral blood lymphocytes , and ( c ) staurosporine induced apoptosis in HUVEC and normal human dermal fibroblasts . Positive_regulation SELE IL1B 14755648 1205835 Both TNF-alpha and *up-regulated* [E-selectin] on the brain endothelium , which correlated with increased signal intensity observed after administration of the novel contrast agent . Positive_regulation SELE IL1B 14762100 1250779 NCX-4016 , but not aspirin , decreased DNA binding of nuclear factor-kappaB (NF-kappaB) on gel shift analysis and HUVEC 's overexpression of CD54 and [CD62E] *induced* by . Positive_regulation SELE IL1B 15148373 1252283 When [E-selectin] was *induced* by , or lipopolysaccharide , human umbilical vein endothelial cells and human dermal microvascular endothelial cells each became markedly more sensitive to inhibition by endostatin in a vascular endothelial growth factor induced cell migration assay . Positive_regulation SELE IL1B 15186945 1256276 Pre-incubation of HAEC with AEM at 20 and 40 microg/ml , but not at 4 microg/ml , for 24h significantly suppressed *stimulated* expressions of intracellular adhesion molecule-1 ( ICAM-1 ) , vascular cell adhesion molecule-1 ( VCAM-1 ) , and [E-selectin] and the secretion of proinflammatory cytokines IL-6 , chemokines IL-8 and monocyte chemoattractant protein (MCP)-1 . Positive_regulation SELE IL1B 15901601 1440272 We demonstrate that treatment of EC with ATL-1 inhibited VCAM and [E-selectin] expression *induced* by TNF-alpha or . Positive_regulation SELE IL1B 16607378 1562653 Experiments in an adoptive transfer model demonstrated that HUVEC containing neovessels are perfused and that *inducible* [E-selectin] expression in these vessels is detectable with non-invasive imaging by using targeted nanoparticles . Positive_regulation SELE IL1B 16776851 1663377 Concomitantly , ALP suppressed the *induced* NF-kappaB activation and the upregulation of [E-selectin] expression in glEND.2 cells in vitro . Positive_regulation SELE IL1B 17170373 1694922 VEGF similarly enhanced *induced* [E-selectin] upregulation . Positive_regulation SELE IL1B 19905948 2161806 A cytokine inactivation assay that measured [E-selectin] expression in *response* to TNF-alpha and was developed to measure the ability of aPDT to inactivate cytokine function . Positive_regulation SELE IL1B 20070238 2201285 In vitro activation of Toll-like receptor 2 (TLR2) , up-regulated in ENL lesions , triggered induction of , which together with interferon gamma *induced* [E-selectin] expression on and neutrophil adhesion to endothelial cells . Positive_regulation SELE IL1B 7523818 272283 These findings suggest that , one of mediators in chronic sinusitis , is produced by PMNs , *induces* the expression of ICAM-1 and [ELAM-1] on endothelial cells , and , thereby , stimulates PMN infiltration in chronic sinusitis . Positive_regulation SELE IL1B 7523851 272287 Transcription of the endothelial leukocyte adhesion molecule 1 ( [E-selectin] or ELAM-1 ) gene is *induced* by the inflammatory cytokines and tumor necrosis factor alpha (TNF-alpha) . Positive_regulation SELE IL1B 7537508 287875 and TNF alpha *increased* the expression of [E-selectin] on the cytoplasmic membranes of HUVECs , HSVECs and HAFECs and elicited even similar absolute quantities of this molecule , comparing the different cell types . Positive_regulation SELE IL1B 7540991 310183 N , N,N-trimethylsphingosine inhibits *induced* NF-kappa B activation and consequent [E-selectin] expression in human umbilical vein endothelial cells . Positive_regulation SELE IL1B 7540991 310186 We examined the effect of N , N,N-trimethylsphingosine ( TMS ) on the *induced* [E-selectin] expression in human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation SELE IL1B 7540991 310187 Incubation of HUVEC with TMS ( 0.1-10 microM ) resulted in a concentration dependent inhibition of *induced* [E-selectin] expression . Positive_regulation SELE IL1B 7545398 318537 The *induced* expression of intercellular adhesion molecule 1 ( ICAM-1 ) , vascular cell adhesion molecule 1 ( VCAM-1 ) and [E-selectin] 1 ( ELAM-1 ) on SMCs was examined by reverse transcription/polymerase chain reaction ( RT/PCR ) . Positive_regulation SELE IL1B 8621602 354191 Regulatory role of ceramide in *induced* [E-selectin] expression in human umbilical vein endothelial cells . Positive_regulation SELE IL1B 8621602 354192 C2-ceramide at 5 micron enhanced *induced* [E-selectin] expression 2.7-fold , whereas other sphingolipids tested had no effects on this process . Positive_regulation SELE IL1B 8621602 354193 Northern blot analyses revealed that C2-ceramide and sphingomyelinase increased *induced* [E-selectin] gene transcription levels . Positive_regulation SELE IL1B 8669721 372359 To further characterize the molecular mechanisms that govern carcinoma cell adhesion to stimulated endothelium , we studied the adhesion of a human colon carcinoma cell line , KM12-L4 , to an [E-selectin-IgG1] chimera and *stimulated* human umbilical vein endothelial cells ( HUVEC ) under in vitro fluid flow conditions . Positive_regulation SELE IL1B 8669721 372360 Rolling KM12-L4 cells exhibit variable velocity motion over both *stimulated* HUVEC and [E-selectin-IgG1] chimera coated surfaces . Positive_regulation SELE IL1B 8866792 344795 In previous studies we have shown that and TNF-alpha *increase* the expression of ICAM-1 , [E-selectin] and VCAM-1 on the cytoplasmatic membranes of HUVECs , HSVECs and HAFECs ( ECs from human umbilical vein , saphenous vein and femoral artery , respectively ) . Positive_regulation SELE IL1B 9030094 413757 Failure to block biosynthesis of [E-selectin] and ICAM-1 *induced* by TNF-alpha and indicates the inhibitory effect exerted by serotonin was selective in nature . Positive_regulation SELE IL1B 9143414 428648 These two secreted glycoproteins could inhibit human polymorphonuclear leukocyte or HL-60 cell adhesion to [E-selectin] transfected COS cells or *stimulated* human endothelial cells in vitro . Positive_regulation SELE IL1B 9188871 437503 Whereas incubation mixtures with pro-IL-1 beta which had been incubated in the absence of SCCE , or with SCCE , which had been incubated in the absence of pro-Il-1 beta , did not induce expression above baseline levels of E-Selectin , which had been incubated with SCCE *induced* a significant increase in [E-Selectin] expression . Positive_regulation SELE IL1B 9194690 438178 M-PSL also inhibited *induced* upregulation of [E-selectin] and ICAM-1 on HUVEC in a dose dependent manner . Positive_regulation SELE IL1B 9234165 445251 Its 50 % inhibitory concentrations ( IC50 ) for the *induced* [ELAM-1] and ICAM-1 expressions were 2.3 x 10 ( -5 ) M and 4.0 x 10 ( -5 ) M , respectively . Positive_regulation SELE IL1B 9234165 445256 In addition , protein C-kinase ( PKC ) inhibitor H7 also inhibited the [ELAM-1] and ICAM-1 expressions *induced* by and TNF-alpha . Positive_regulation SELE IL1B 9378988 465722 The inhibitory effect of IFN-gamma on poly ( I:C ) -induced E-selectin was concentration and time dependent and was specific for dsRNA , in that the *induction* of [E-selectin] by TNF-alpha , , thrombin , or LPS was not inhibited significantly by this pretreatment . Positive_regulation SELE IL1B 9448041 483775 TNF-alpha and *increased* the expression of ICAM-1 , [E-selectin] , and VCAM-1 , whereas IL-4 induced only that of VCAM-1 . Positive_regulation SELE IL1B 9920928 588130 The lower classic PKC activity on pretreatment with phorbol ester ( phorbol 12-myristate 13-acetate ( PMA ) ) for 24 h markedly decreased *induced* [E-selectin] mRNA expression in the presence of fetal calf serum and basic fibroblast growth factor , although the induction of ICAM-1 mRNA expression was only influenced a little by the PKC down-regulation . Positive_regulation SELE IL1B 9973188 560259 Auranofin ( AF ) interacted with HUVEC and PMN adhesiveness but in opposite directions : this drug hampered *induced* HUVEC hyperadhesiveness and expression of [E-selectin] and intercellular adhesion molecule 1 , but augmented PMN adherence and CD18 expression . Positive_regulation SELE ITGAL 17543554 1762556 Slow rolling on E-selectin coimmobilized with intercellular adhesion molecule-1 ( ICAM-1 ) required P-selectin glycoprotein ligand (PSGL)-1 , was *dependent* on ( LFA-1 ) , and required continuous [E-selectin] engagement . Positive_regulation SELE ITGB2 17543554 1762557 Slow rolling on E-selectin coimmobilized with intercellular adhesion molecule-1 ( ICAM-1 ) required P-selectin glycoprotein ligand (PSGL)-1 , was *dependent* on ( LFA-1 ) , and required continuous [E-selectin] engagement . Positive_regulation SELE PECAM1 9506571 491433 In early lesions , expression of , ICAM-1 , ICAM-2 , and P-selectin was similar to that in control samples , and VCAM-1 and [E-selectin] were *induced* in vascular endothelium . Positive_regulation SELE TNF 10030794 591783 *Role* of and interferon gamma in endotoxin induced [E-selectin] expression . Positive_regulation SELE TNF 10195917 604204 [E-selectin] expression in *response* to was , as expected , inhibited in ECs that had been preincubated with HDLs . Positive_regulation SELE TNF 10199816 605356 also significantly *enhanced* surface expression of vascular cell adhesion molecule 1 and [E-selectin] ( in HUVEC only ) , as well as intercellular adhesion molecule 1 ( ICAM-1 ; in HUVEC and ECV ) . Positive_regulation SELE TNF 10443926 635849 Cells with marked depletion of cytoplasmic GSH , but with an intact pool of mitochondrial GSH , only slightly enhanced *induced* [E-selectin] and vascular cell adhesion molecule-1 ( VCAM-1 ) expression , compared with the control . Positive_regulation SELE TNF 10466115 640657 Characterization of the isolated cultures included expression of endothelial cell markers , regulation of [E-selectin] in *response* to , proliferative response to angiogenic growth factors , and expression of progesterone and estrogen receptors . Positive_regulation SELE TNF 10466115 640659 HEEC also upregulated [E-selectin] in *response* to in a manner similar to that seen for other endothelial cell types . Positive_regulation SELE TNF 10484438 644091 The dual radiolabeled monoclonal antibody technique was used to quantify constitutive and *induced* expression of intercellular adhesion molecule 1 ( ICAM-1 ) , vascular cell adhesion molecule 1 ( VCAM-1 ) , ICAM-2 , P-selectin , [E-selectin] , and platelet-endothelial cell adhesion molecule 1 ( PECAM-1 ) in different vascular beds of normal ( C57Bl/6 ) and RM-1 tumor bearing mice . Positive_regulation SELE TNF 10556825 566011 We found that lipophilic substance ( s ) present in the excretory/secretory products from schistosomula selectively reduce the *induced* synthesis of [E-selectin] and VCAM-1 mRNA and proteins without affecting ICAM-1 . Positive_regulation SELE TNF 10576620 569493 We demonstrate here that out of three compounds , viz diferuloylmethane , p-coumaroylferuloylmethane and di-p-coumaroylmethane , present in the ethyl acetate extract of Curcuma longa , diferuloylmethane is most potent in inhibiting *induced* expression of ICAM-1 , VCAM-1 and [E-selectin] on human umbilical vein endothelial cells . Positive_regulation SELE TNF 10580548 570083 *Induction* of intercellular adhesion molecule ( ICAM-1 ) , vascular cell adhesion molecule ( VCAM-1 ) and [E-selectin] by , measured by a radiometric technique , was similar in IVEC and HUVEC , while the induction of E-selectin by IL-1beta on IVEC was limited and significantly different from that observed on HUVEC ( p < 0.001 ) . Positive_regulation SELE TNF 10626906 576315 The addition of troglitazone to HUVECs significantly reduced the expression of ICAM-1 , VCAM-1 and [E-selectin] *induced* by alone or in combination with oxidized LDL ( p < 0.001 ) ; Positive_regulation SELE TNF 10638837 576812 Significant differences were found in the ability to respond to cytokines between HUVEC and the cell lines , the greatest differences being induction of VCAM-1 and [E-selectin] in *response* to and induction of MHC class II antigens in response to IFN-gamma . Positive_regulation SELE TNF 10657661 664134 *Induction* of [E-selectin] expression by double stranded RNA and is attenuated in murine aortic endothelial cells derived from double stranded RNA activated kinase ( PKR ) -null mice . Positive_regulation SELE TNF 10657661 664136 Because we have previously shown that the dsRNA activated kinase PKR mediates dsRNA induction of NF-kappaB , we used murine aortic endothelial ( MuAE ) cells isolated from wild-type and PKR-null mice to investigate the role of PKR in the *induction* of [E-selectin] expression by dsRNA ( pIC ) and . Positive_regulation SELE TNF 10657661 664143 Induction of E-selectin promoter activity and NF-kappaB DNA binding activity were substantially reduced in pIC- or TNF-alpha treated PKR-null cells , indicating a role for PKR in both pIC and *induction* of [E-selectin] via an NF-kappaB dependent pathway . Positive_regulation SELE TNF 10657661 664144 These results indicate that the PKR is required for full *activation* of [E-selectin] expression by pIC and in primary mouse aortic endothelial cells identifying activating transcription factor 2 as a new target for PKR dependent regulation and suggest a role for PKR in leukocyte adhesion . Positive_regulation SELE TNF 10678982 668436 It has been shown that the membrane attack complex ( MAC ) ( C5b-C9 ) can enhance *induced* expression of P- and [E-selectin] and intercellular adhesion molecule type 1 in cell cultures of human umbilical vein endothelial cells . Positive_regulation SELE TNF 10706724 673344 Basal expression by PAEC of P-selectin was greater than that of E-selectin , whereas [E-selectin] expression was more prominently enhanced than that of P-selectin by *stimulation* with or IL-1alpha . Positive_regulation SELE TNF 10755555 682766 It is interesting that in vivo studies confirmed that CsA and GC inhibited EC activation at therapeutic doses ( 1 mg/kg and 10 mg/kg for GC and CsA , respectively ) and showed that the combination of CsA and GC efficiently prevents *mediated* induction of [E-selectin] on cardiac ECs . Positive_regulation SELE TNF 10771568 686193 The expression of ICAM-1 and [E-selectin] *induced* by was not inhibited by either bFGF or VEGF . Positive_regulation SELE TNF 10807781 692327 *induced* the expression of VCAM-1 , [E-selectin] , and ICAM-1 but had no effect on P-selectin expression . Positive_regulation SELE TNF 10859217 704802 These findings suggest that superoxide and *mediate* gut I/R induced [E-selectin] expression via an NF-kappaB dependent mechanism ; Positive_regulation SELE TNF 10964678 727870 Repression of *induced* [E-selectin] expression by PPAR activators : involvement of transcriptional repressor LRF-1/ATF3 . Positive_regulation SELE TNF 10964678 727873 Troglitazone , pioglitazone , alpha-clofibrate , and 15-deoxy-Delta12,14-prostaglandin J2 all inhibited the *stimulated* [E-selectin] gene transcription in reporter assay . Positive_regulation SELE TNF 11110771 757361 In conclusion , induced neutrophil recruitment into the brain *requires* both endothelial [E-selectin] and P-selectin as well as platelets , but platelet P-selectin was not a major contributor to this process . Positive_regulation SELE TNF 11162639 782333 Since hyperhomocysteinemia appears to be an independent risk factor for the development of atherosclerosis , in this study we investigated the effect of homocysteine on basal and *induced* expression of intercellular adhesion molecule-1 ( ICAM-1 ) , vascular cell-adhesion molecule-1 ( VCAM-1 ) , and endothelial leukocyte adhesion molecule-1 ( [E-selectin] ) on human umbilical-vein endothelial cells . Positive_regulation SELE TNF 11162639 782337 Incubation of endothelial cells with homocysteine resulted in dose dependent reduction in *induced* ( 5 ng/ml ) expression of VCAM-1 , [E-selectin] , and ICAM-1 ( the latter less pronounced ) . Positive_regulation SELE TNF 11300880 803294 A thieno [ 2,3-d ] pyrimidine , A-155918 , was identified from a whole-cell high-throughput assay for compounds which inhibited the *induced* expression of [E-selectin] , ICAM-1 , or VCAM-1 on human vascular endothelial cells . Positive_regulation SELE TNF 11355655 815434 Control skin displayed no expression of E- and P-selectin , whereas *induced* the expression of P-selectin and [E-selectin] on dermal vessels that was highest at 12 hours and 3 hours , respectively ( P < 0.05 ) . Positive_regulation SELE TNF 11355655 815438 These results demonstrate that can *induce* the expression of P- and [E-selectin] in vivo in dog skin and suggest that these selectins are involved in leukocyte recruitment in canine dermatitis . Positive_regulation SELE TNF 11403206 824941 At 4 h ICAM-1 and [E-selectin] , but not VACM-1 , were *stimulated* by both IL-1beta and . Positive_regulation SELE TNF 11403206 824947 Blocking PARP via GPI 6150 only affected *induced* [E-selectin] expression at 4 hours . Positive_regulation SELE TNF 11403206 824948 ICAM-1 , VCAM-1 , and [E-selectin] expression were all *stimulated* by both IL-1beta and in the 24 h assays . Positive_regulation SELE TNF 11436044 832708 Aprotinin inhibited *stimulated* expression of intercellular adhesion molecule-1 ( P =.019 at 1600 kIU/mL ) and vascular cell adhesion molecule-1 ( P =.003 at 1600 kIU/mL ) but not [E-selectin] . Positive_regulation SELE TNF 11678640 873683 *induced* the expression of [E-selectin] on all three kinds of endothelial cells , but IFN-gamma had no effect on E-selectin expression . Positive_regulation SELE TNF 11716764 881788 In contrast , *induced* [E-selectin] protein expression was augmented after mevastatin treatment . Positive_regulation SELE TNF 11716764 881789 Analysis of the time dependent variation in the *induced* expression of [E-selectin] , and estimation of the rate of surface disappearance of E-selectin together with measurement of the amounts of E-selectin molecules secreted , indicated that mevastatin inhibited the surface removal of E-selectin . Positive_regulation SELE TNF 11746205 887596 Surface ELISA indicated that PTX reduced *induced* upregulation of [E-selectin] . Positive_regulation SELE TNF 11886496 894177 Dimethylfumarate inhibits *induced* [CD62E] expression in an NF-kappa B-dependent manner . Positive_regulation SELE TNF 11886496 894178 Using human umbilical vein endothelial cells , dimethylfumarate almost completely inhibited *induced* [CD62E] , but not CD54 expression at concentrations < or = 70 microM , mimicking the situation in vivo . Positive_regulation SELE TNF 11886496 894180 A 60 min dimethylfumarate preincubation was sufficient to block *induced* [CD62E] expression for up to 24 h . Positive_regulation SELE TNF 11886496 894181 In contrast , equimolar concentrations of methylhydrogenfumarate , the hydrolysis product of dimethylfumarate , did not suppress *induced* [CD62E] expression . Positive_regulation SELE TNF 11886496 894182 Using CD62E , NF-kappa B , or AP-1-responsive promoter constructs , dimethylfumarate inhibited *induced* activation of the [CD62E] and the NF-kappa B but not the AP-1 promoter construct . Positive_regulation SELE TNF 12014678 941705 [E-selectin] ( peak at 4 hours ) and VCAM-1 ( peak at 24 hours ) expression were significantly *increased* by but unchanged by reduced oxygenation . Positive_regulation SELE TNF 12020745 942682 Effects of testosterone and 17-beta-estradiol on *induced* [E-selectin] and VCAM-1 expression in endothelial cells . Positive_regulation SELE TNF 12020745 942684 This study investigated the effects of testosterone and 17-beta-estradiol on *induced* endothelial expression of [E-selectin] and vascular cell adhesion molecule-1 ( VCAM-1 ) and the potential roles of hormone receptors involved in these actions . Positive_regulation SELE TNF 12020745 942686 As shown by Western blot analysis , co-administration with testosterone or 17-beta-estradiol increased the expression of [E-selectin] and VCAM-1 *induced* by at 6 h and 3 h , respectively . Positive_regulation SELE TNF 12020745 942688 Flow cytometric analysis showed that preincubation with androgen receptor antagonist cyproterone and estrogen receptor antagonist tamoxifen completely abrogated the upregulating effects of testosterone and 17-beta-estradiol on *induced* [E-selectin] and VCAM-1 expression , respectively . Positive_regulation SELE TNF 12020745 942690 The data indicate that both testosterone and 17-beta-estradiol increase *induced* [E-selectin] and VCAM-1 expression in endothelial cells via a receptor mediated system , and expression of TNF receptors are not changed in these actions . Positive_regulation SELE TNF 12056511 951863 This finding was supported by the inability of TTO to suppress *induced* [E-selectin] expression by human umbilical vein endothelial cells . Positive_regulation SELE TNF 12087872 959464 It is concluded that both testosterone and 17 beta-estradiol increase *induced* expression of [E-selectin] and VCAM-1 in endothelial cells and these facts might indicate a mechanism by which gonadal hormones can indirectly enhance immune responses . Positive_regulation SELE TNF 12208465 983775 Increased intracellular calcium transients by calmodulin antagonists differentially modulate *induced* [E-selectin] and ICAM-1 expression . Positive_regulation SELE TNF 12208465 983777 The increased [ Ca ( 2+ ) ] ( i ) acted as a second messenger to enhance *induced* [E-selectin] and suppress intercellular cell adhesion molecule ( ICAM-1 ) expression . Positive_regulation SELE TNF 12237332 989179 *induced* endothelial VCAM-1 , ICAM-1 , and [E-selectin] surface expression was inhibited dose dependently . Positive_regulation SELE TNF 12372676 996455 Although zofenoprilat significantly and dose dependently reduced the expression of vascular cell adhesion molecule-1 ( VCAM-1 ) , intercellular cell adhesion molecule-1 ( ICAM-1 ) , and [E-selectin] *induced* by ox-LDL ( P < .01 ) and ( P < .01 ) on HUVECs , enalaprilat did not . Positive_regulation SELE TNF 12420742 1013414 Monochloramine inhibits the expression of [E-selectin] and intercellular adhesion molecule-1 *induced* by through the suppression of NF-kappaB activation in human endothelial cells . Positive_regulation SELE TNF 12420742 1013416 We studied the effects of monochloramine ( NH2Cl ) , a physiological oxidant derived from activated neutrophils , on the *induced* expression of [E-selectin] and intercellular adhesion molecule-1 ( ICAM-1 ) in human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation SELE TNF 12420742 1013418 Without NH2Cl , *induced* marked expression of [e-selectin] and ICAM-1 . Positive_regulation SELE TNF 12420742 1013422 These observations indicated that NH2Cl inhibited *induced* expression of [E-selectin] and ICAM-1 through the inhibition of NF-kappaB activation . Positive_regulation SELE TNF 12438297 1016541 Stimulation of the Ad.null infected endothelial cells with *resulted* in enhanced expression of endothelial intracellular adhesion molecule-1 , vascular cellular adhesion molecule-1 , and [E-selectin] and enhanced adhesion of monocytic U937 cells to the HAECs . Positive_regulation SELE TNF 12488365 1033013 In HDMEC , alpha-MSH ( 10 ( -8 ) /10 ( -12 ) M ) profoundly reduced the mRNA and protein expression of [E-selectin] , vascular CAM (VCAM)-1 , and intercellular CAM (ICAM)-1 *induced* by LPS or as determined by semiquantitative RT-PCR , ELISA , and fluorescence activated cell sorter analysis . Positive_regulation SELE TNF 12514595 1039167 Although fluid flow did not reduce total cellular [E-selectin] mRNA levels in *response* to , the amount of E-selectin mRNA present in the actively translated polysome fraction was markedly attenuated . Positive_regulation SELE TNF 12603864 1062567 MG132 only partially blocked tumor necrosis factor-alpha induced tissue factor protein expression , despite an almost complete inhibition of *induced* [E-selectin] expression . Positive_regulation SELE TNF 12606638 1079729 In the present study , we demonstrate that adenoviral mediated expression of dominant negative N17Rac1 ( Ad.N17Rac1 ) suppresses *induced* vascular cell adhesion molecule-1 ( VCAM-1 ) , intercellular adhesion molecule-1 ( ICAM-1 ) , and [E-selectin] gene expression in a dose dependent manner . Positive_regulation SELE TNF 12606638 1079740 In contrast , Ad.N17Rac1 inhibited TNF-alpha induced NF-kappaB-driven HIV ( kappaB ) ( 4 ) -CAT and p288VCAM-Luc promoter activity , suggesting that N17Rac1 inhibits *induced* VCAM-1 , [E-selectin] , and ICAM-1 through suppressing NF-kappaB mediated transactivation . Positive_regulation SELE TNF 12606638 1079753 In addition , expression of superoxide dismutase by adenovirus suppressed *induced* VCAM-1 , [E-selectin] , and ICAM-1 mRNA accumulation . Positive_regulation SELE TNF 12606638 1079757 However , adenoviral mediated expression of catalase only partially inhibited *induced* [E-selectin] gene expression and had no effect on VCAM-1 and ICAM-1 gene expression . Positive_regulation SELE TNF 12633744 1068265 Treatment of HAEC with DFO ( 0.01-0.1 mM ) or NC ( 0.1 and 0.5 mM ) time- and dose-dependently inhibited *induced* protein expression of [E-selectin] , vascular cell adhesion molecule-1 ( VCAM-1 ) , and intercellular adhesion molecule-1 ( ICAM-1 ) . Positive_regulation SELE TNF 12682486 1077807 Gabexate mesilate inhibited the *induced* increases in the endothelial expression of [E-selectin] and intercellular adhesion molecule-1 by inhibiting the transcription . Positive_regulation SELE TNF 12788693 1133976 2 ) 4-h *induced* expression of [E-selectin] , VCAM-1 , and HL60 cell adhesion to HUVEC that have become desensitized to IL-1 beta activation ; Positive_regulation SELE TNF 1279276 202984 We therefore studied the relation between the duration of TNF alpha/TNF receptor interaction and the extent of the induced biological effects in two different in vitro systems : ( 1 ) the slowly induced cytotoxicity of the TNF-sensitive murine cell line L929 , and ( 2 ) the rapid *induced* expression of an adhesion molecule for the polymorphonuclear cell , [ELAM-1] on human endothelial cells . Positive_regulation SELE TNF 1279276 202985 To establish an optimal effect for both *induced* cytotoxicity on L929 cells and TNF alpha induced expression of [ELAM-1] on human endothelial cells , the TNF receptor had to be occupied by TNF alpha for at least 30-60 % of the full incubation period . Positive_regulation SELE TNF 12919942 1157687 activation of HEMEC *resulted* in upregulation of the cell adhesion molecules (CAM) ICAM-1 , VCAM-1 , [E-selectin] , and mucosal addressin CAM-1 (MAdCAM-1) , increased IL-8 production , and enhanced leukocyte binding . Positive_regulation SELE TNF 1381227 196038 The present study aimed to see whether *induction* of [ELAM-1] and ICAM-1 on human umbilical vein endothelial cells ( HUVECs ) involved novel TNF-receptor interactions . Positive_regulation SELE TNF 1381227 196042 It is concluded that ( a ) the same part of the TNF molecule interacts with TNF-receptors on HUVECs and other cell types and ( b ) *induction* of [ELAM-1] and ICAM-1 on HUVECs is mediated via the well characterized 55 kDa TNF receptor . Positive_regulation SELE TNF 1382639 198287 Exposure of HUVEC to perflubron did not alter the up-regulation of ICAM or [ELAM] in *response* to IL-1 or ( n = 20 ) . Positive_regulation SELE TNF 14511654 1146663 We here investigated the effects of sphingosylphosphorylcholine (SPC) and lysosulfatide ( LSF ) , two lysosphingolipids associated with HDL , on *induced* [E-selectin] expression in human umbilical endothelial cells . Positive_regulation SELE TNF 14511654 1146666 The inhibitory effects of HDL , SPC , and LSF on *induced* [E-selectin] expression were partially reverted in the presence of suramin , an antagonist of lysosphingolipid receptor EDG-3 , or pertussis toxin , an inhibitor of trimeric G proteins . Positive_regulation SELE TNF 14565715 1154952 HPVEC express [E-selectin] , ICAM-1 , and VCAM-1 in *response* to the inflammatory cytokine similarly to other types of cultured human endothelial cells . Positive_regulation SELE TNF 14584040 1187133 The catalytic Sec residue of TrxR1 , which is essential for reducing Trx , was required for this NF-kappa B activation , and aurothiomalate , an inhibitor of TrxR , suppressed *induced* activation of NF-kappa B and the expression of NF-kappa B-targeted proinflammatory genes such as [E-selectin] and cyclooxygenase-2 . Positive_regulation SELE TNF 14615388 1188001 Shear stress increases ICAM-1 and decreases VCAM-1 and [E-selectin] expressions *induced* by [ alpha ] in endothelial cells . Positive_regulation SELE TNF 14615388 1188003 Shear stress increased the TNF-alpha induced expression of intercellular adhesion molecule-1 ( ICAM-1 ) at both mRNA and surface protein levels , but decreased the *induced* expression of vascular adhesion molecule-1 (VCAM-1) and [E-selectin] . Positive_regulation SELE TNF 14615388 1188008 Our findings suggest that shear stress plays differential roles in modulating the *induced* expressions of ICAM-1 versus VCAM-1 and [E-selectin] genes in ECs . Positive_regulation SELE TNF 14630701 1188067 *induces* [E-selectin] gene and protein expression in primary human endothelial cells ( HUVEC ) and in an endothelial cell line ( EA.hy-926 ) . Positive_regulation SELE TNF 14669262 1178194 The present study investigates the suppressive effect of flavonoids on *stimulated* [E-selectin] expression on HUVECs by carrying out a comparative examination of the 37 flavonoids . Positive_regulation SELE TNF 14682382 1179318 and IL-10 *enhanced* [ELAM-1] on DU 145 , but EosA 24 hr supematants failed to do so . Positive_regulation SELE TNF 14682382 1179320 All three cytokines , namely IL-10 , IL-12 and *induced* [ELAM-1] on PC-3 tumor cells . Positive_regulation SELE TNF 14682399 1179325 Using semi-quantitative RT-PCR and cell based ELISA , we demonstrated that *induced* the expression of intercellular adhesion molecules-1 and [E-selectin] , as well as monocyte chemoattractant protein-1 , in a time- and dose dependent manner in primary human coronary artery endothelial cell cultures . Positive_regulation SELE TNF 14741740 1203363 Hepatocyte growth factor/scatter factor suppresses *induced* [E-selectin] expression in human umbilical vein endothelial cells . Positive_regulation SELE TNF 14741740 1203364 Prior treatment of HUVEC with HGF significantly attenuated the *induced* E-selectin protein , adhesion of HL60 cells to HUVEC and [E-selectin] mRNA expression in a dose dependent manner , while HGF itself did not exert any effects . Positive_regulation SELE TNF 14755648 1205834 Both and IL-1beta *up-regulated* [E-selectin] on the brain endothelium , which correlated with increased signal intensity observed after administration of the novel contrast agent . Positive_regulation SELE TNF 14764813 1207442 Furthermore , we studied the direct effect of GH and IGF-I and serum from GH-treated subjects on basal and *stimulated* expression of VCAM-1 and [E-selectin] on cultured human umbilical vein endothelial cells . Positive_regulation SELE TNF 14991270 1215460 The *induced* expression of the endothelial adhesion molecule [E-selectin] was not reduced in response to DADS or AM . Positive_regulation SELE TNF 15113938 1241385 significantly *induced* HUVEC protein expression of VCAM-1 , ICAM-1 , and [E-selectin] with increasing mRNA levels . Positive_regulation SELE TNF 15167972 1253503 Moreover , the inhibitory effects of IVIG on IkappaBalpha degradation , interleukin-6 (IL-6) production , and [E-selectin] expression *induced* by were evaluated by Western blot analysis , ELISA , and flow cytometry , respectively . Positive_regulation SELE TNF 15167972 1253508 Moreover , IVIG inhibited IkappaBalpha degradation , IL-6 production , and [E-selectin] expression *induced* by in CAEC . Positive_regulation SELE TNF 15231489 1295764 The rapid and transient *induction* of [E-selectin] gene expression by inflammatory in endothelial cells is mediated by signaling pathways which involve c-Jun N-terminal kinase (JNK) and p38 mitogen activated protein kinase (MAPK) kinase pathways . Positive_regulation SELE TNF 15265939 1275742 We found that compound 10 1 ) dramatically inhibits TNF-alpha induced VCAM-1 mRNA and protein expression in human aortic endothelial cells ( HAEC ) , has a relatively modest inhibitory effect on *induced* [E-selectin] expression and has no effect on ICAM-1 expression ; Positive_regulation SELE TNF 15286208 1322171 In particular , the *induction* of the adhesion molecule [E-selectin] by either or Escherichia coli lipopolysaccharide (LPS) was reduced by more than 70 % in HUVECs , whereas inducible nitric-oxide synthase (iNOS) induction was abolished in C6 cells after exposure to interferon-gamma in combination with LPS and TNFalpha , suggesting that the receptor inhibited a common step in the induction of each of these pro-inflammatory genes . Positive_regulation SELE TNF 15374848 1323857 Carvedilol inhibited *stimulated* endothelial vascular cell adhesion molecule-1 ( VCAM-1 ) and [E-selectin] ( 66.0+/-2.0 % and 55.60+/-1.0 % of control , P < 0.05 , respectively ) expression , whereas probucol inhibited only VCAM-1 expression ( 79.0+/-5.0 % of control , P < 0.05 ) . Positive_regulation SELE TNF 15479458 1319775 We first evaluated by flow cytometry the pTNFR1Ig capacity to prevent *induced* expression of SLAI , SLAII , VCAM-1 , ICAM-1 and [E-selectin] on the cell surface of porcine aortic endothelial cells ( PAEC ) . Positive_regulation SELE TNF 15548964 1338484 Altogether , our results demonstrate that [E-selectin] expression ( 1 ) is not a *consequence* of triggering , ( 2 ) up-regulates its own expression and expression of I-A , VCAM-1 , TNF-alpha , and lymphotoxin-alpha mRNAs , and ( 3 ) down-regulates expression of LFA-3 and ICAM-1 mRNAs . Positive_regulation SELE TNF 15583752 1345354 These observations suggested that AT inhibited the *induced* increase in [E-selectin] expression in HUVECs by inhibiting the interaction of NF-kappaB with CBP/p300 through cAMP dependent protein kinase A-induced CREB activation . Positive_regulation SELE TNF 15625106 1362069 As in skin , *induces* [E-selectin] and vascular cell adhesion molecule 1 only on venular ECs , whereas intercellular adhesion molecule-1 is up-regulated on all human ECs . Positive_regulation SELE TNF 15637427 1362760 In these cells , ICAM-1 and [E-selectin] expression was *up-regulated* by , as in native cultured HGEC . Positive_regulation SELE TNF 15671209 1366092 Phloretin prevented *stimulated* upregulation of VCAM-1 , ICAM-1 , and [E-selectin] expression in a concentration dependent manner . Positive_regulation SELE TNF 15742809 1378890 Also , 1 and 2 inhibited *induced* up-regulation of ICAM-1 , VCAM-1 and [E-selectin] . Positive_regulation SELE TNF 15880045 1406191 stimulation of PAEC-Gal-/- and PAEC-Gal+/+ *induced* an increase of [CD62E] and CD106 expression and increased cellular adhesion , in particular , of PMN . Positive_regulation SELE TNF 15901601 1440271 We demonstrate that treatment of EC with ATL-1 inhibited VCAM and [E-selectin] expression *induced* by or IL-1beta . Positive_regulation SELE TNF 15937521 1440458 *increased* [E-selectin] mRNA expression in both wild-type ( WT ) and mast cell-deficient mice . Positive_regulation SELE TNF 15969490 1423822 In contrast , hydroxyflavone minimally inhibited *stimulated* [E-selectin] expression without affecting VCAM-1 level . Positive_regulation SELE TNF 16135789 1450384 Reconstitution of RelA-deficient murine embryonic fibroblasts with RelA S276A or RelA S536A decreased *induced* acetylation of lysine 310 and expression of the endogenous NF-kappaB-responsive [E-selectin] gene . Positive_regulation SELE TNF 16243974 1476847 We demonstrate that CpdA exerts an antiinflammatory potential by down modulating *induced* proinflammatory gene expression , such as IL-6 and [E-selectin] , but , interestingly , does not at all enhance glucocorticoid response element-driven genes or induce GR binding to glucocorticoid response element dependent genes in vivo . Positive_regulation SELE TNF 16266460 1478861 We investigated the expression of lectin-like oxidized low-density lipoprotein receptor-1 ( LOX-1 ) , intercellular adhesion molecule-1 ( CAM-1 ) , [E-selectin] *induced* by in human umbilical vein endothelial cells ( HUVECs ) , and their effects on adhesion of monocyte to HUVECs . Positive_regulation SELE TNF 16309209 1486598 These findings support the hypothesis that expression of [E-selectin] and VCAM-1 may be *initiated* by the release of at an early stage of tumour development . Positive_regulation SELE TNF 16313198 1486901 Using primary human umbilical vein endothelial cells , we evaluated the activities of compound 1 on *induced* expression of cell adhesion molecules , viz. , ICAM-1 , VCAM-1 , and [E-selectin] , which play key roles in controlling various inflammatory diseases . Positive_regulation SELE TNF 16353157 1526368 We show that phenoxodiol inhibits hallmarks of endothelial cell activation , namely or IL-1 *induced* [E-selectin] and VCAM-1 expression and IL-8 secretion . Positive_regulation SELE TNF 16440418 1516618 To examine whether antithrombin ( AT ) could prevent hepatic ischemia/reperfusion ( I/R ) -induced hepatic metastasis by inhibiting *induced* expression of [E-selectin] in rats . Positive_regulation SELE TNF 16440418 1516619 AT might reduce I/R induced hepatic metastasis of colon cancer cells by inhibiting *induced* expression of [E-selectin] through an increase in the endothelial production of PGI2 . Positive_regulation SELE TNF 16450077 1521975 In previous studies we have shown that high density lipoproteins ( HDL ) and the HDL associated sphingosylphosphorylcholine (SPC) have the ability to suppress the *induced* expression of endothelial cell [E-selectin] . Positive_regulation SELE TNF 16501492 1541635 In vitro , HGF suppressed *induced* cell surface expression of [E-selectin] in human umbilical vein endothelial cells ( HUVEC ) and inhibited E-selectin mediated monocytic adhesion to endothelial monolayers . Positive_regulation SELE TNF 16501492 1541640 In addition , selective inhibition of GSK3 activity by lithium suppressed *induced* [E-selectin] expression and monocytic adhesion , reminiscent of the action of HGF . Positive_regulation SELE TNF 16644735 1583262 In this study , we have shown that , in ECs , Lnk down-regulates the expression , at both mRNA and protein levels , of the proinflammatory molecules VCAM-1 and [E-selectin] *induced* by . Positive_regulation SELE TNF 16803639 1579428 RGD targeted adenovirus delivered the dnIkappaB via alphavbeta3 to become functionally expressed , leading to complete abolishment of *induced* up-regulation of [E-selectin] , ICAM-1 , VCAM-1 , IL-6 , IL-8 , VEGF-A and Tie-2 . Positive_regulation SELE TNF 1695647 137149 Furthermore , IL-4 exhibited significant synergy with IL-1 or TNF in inducing 1.4C3 Ag expression ( p less than 0.001 ) but inhibited the increased expression of ICAM-1 produced by IL-1 , TNF , or IFN-gamma ( p less than 0.01 ) and inhibited the *induction* of [ELAM-1] by IL-1 and ( p less than 0.001 ) . Positive_regulation SELE TNF 1697308 139530 IFN-gamma increases *induced* [ELAM-1] expression such that a greater number of EC express ELAM-1 at both 4 and 24 h in the presence of IFN-gamma plus TNF compared to cultures treated with TNF alone , although the maximal level of surface expression on individual cells is not increased . Positive_regulation SELE TNF 1697876 139665 [ELAM-1] is normally not expressed by HUVE cells , but its expression can rapidly be *induced* by , IL-1 , or LPS . Positive_regulation SELE TNF 17068152 1693042 We observed that p75 was essential for *induced* [E-selectin] , vascular cell adhesion molecule 1 ( VCAM-1 ) , and intercellular adhesion molecule 1 ( ICAM-1 ) expression . Positive_regulation SELE TNF 17126899 1677665 The inhibition of *induced* [E-selectin] expression in endothelial cells via the JNK/NF-kappaB pathways by highly N-acetylated chitooligosaccharides . Positive_regulation SELE TNF 17126899 1677666 The results show that pre treating ECs with NACOS inhibited the *induced* [E-selectin] expression in a dose- and time dependent manner . Positive_regulation SELE TNF 17126899 1677681 the inhibitor for JNK ( i.e. , SP600125 ) , but not those for ERK ( i.e. , PD98059 ) and p38 MAPK ( i.e. , SB203580 ) , attenuated this *induced* [E-selectin] expression . Positive_regulation SELE TNF 17126899 1677682 Pre treating ECs with NACOS inhibited the TNF-alpha induced JNK activation , suggesting that JNK was involved in the inhibitory effect of NACOS on *induced* [E-selectin] expression . Positive_regulation SELE TNF 17126899 1677684 Our findings provide a molecular mechanism by which NACOS inhibit *induced* [E-selectin] expression in ECs , and a basis for using NACOS in pharmaceutical therapy against inflammation . Positive_regulation SELE TNF 17170373 1694920 In contrast , pretreatment of human umbilical vein endothelial cells with VEGF significantly increased [E-selectin] expression *induced* by , compared with tumor necrosis factor-alpha alone , whereas vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 were unaffected . Positive_regulation SELE TNF 17209004 1732457 Venous and coronary artery flow both increased *induced* [E-selectin] and ICAM-1 expression on HSVEC , but only coronary artery flow increased VCAM-1 expression . Positive_regulation SELE TNF 17209004 1732459 In marked contrast to HSVEC , venous and coronary artery flow attenuated *induced* [E-selectin] and VCAM-1 expression on HCAEC , whereas coronary artery flow further induced ICAM-1 on cytokine stimulated HCAEC . Positive_regulation SELE TNF 17209004 1732463 Interestingly , Kruppel-like factor (KLF) 4 overexpression in HCAEC and HSVEC significantly reduced *induced* [E-selectin] and VCAM-1 expression in static conditions , while ICAM-1 expression remained constant . Positive_regulation SELE TNF 17235725 1664231 significantly *increased* EC [E-selectin] surface expression . Positive_regulation SELE TNF 17235725 1664232 These results indicate that activation , but not apoptosis , is *necessary* for [E-selectin] surface expression in EC . Positive_regulation SELE TNF 17259331 1691245 Isoliquiritigenin abolished *induced* mRNA accumulation of VCAM-1 and [E-selectin] . Positive_regulation SELE TNF 17321745 1711802 We have found that compound 8a also significantly inhibited the *induced* expression of VCAM-1 and [E-selectin] , which play key roles in various inflammatory diseases . Positive_regulation SELE TNF 17452460 1743127 The depletion of HOXA9 protein in ECs resulted in a significant and specific decrease in *induced* [E-selectin] gene expression . Positive_regulation SELE TNF 17452460 1743131 We have thus identified a novel and functionally critical cis-regulatory element for *mediated* transient expression of the [E-selectin] gene . Positive_regulation SELE TNF 17704822 1806044 In vitro , the effects of roflumilast N-oxide , the active metabolite of roflumilast in humans , and other PDE4 inhibitors on neutrophil adhesion to *activated* human umbilical vein endothelial cells ( HUVEC ) , [E-selectin] expression and thrombin induced endothelial permeability was evaluated . Positive_regulation SELE TNF 17704822 1806045 It also reduced *induced* [E-selectin] expression on HUVEC , when PDE3 activity was blocked . Positive_regulation SELE TNF 17706953 1816843 OPG but not OPN stimulated a dose dependent increase in the expression of intercellular adhesion molecule-1 , vascular cell adhesion molecule-1 and [E-selectin] by endothelial cells in the *presence* of ( p < or=0.05 ) which was reflected by enhanced binding of THP-1 monocytes . Positive_regulation SELE TNF 18025230 1827735 Basal and *induced* expression of VCAM-1 , ICAM-1 , and [E-selectin] were increased in Hmox1 ( -/- ) vs Hmox1 ( +/+ ) EC , an effect reversed by Fe chelation using deferoxamine mesylate ( DFO ) . Positive_regulation SELE TNF 18036803 1852192 omega-3 PUFA and other concentrations of CLA and *induced* [E-selectin] expression were unaffected . Positive_regulation SELE TNF 18038911 1828522 Apigenin significantly suppressed the *stimulated* upregulation of vascular cellular adhesion molecule-1 ( VCAM-1 ) - , intracellular adhesion molecule-1 ( ICAM-1 ) - , and [E-selectin-mRNA] to the basal levels . Positive_regulation SELE TNF 18048767 1852480 In human umbilical vein endothelial cells ( HUVECs ) , the synthetic PPAR-delta ligands GW0742 and GW501516 significantly inhibited *induced* expression of vascular cell adhesion molecule-1 and [E-selectin] ( assayed by real-time RT-PCR and Northern blotting ) , as well as the ensuing endothelial-leukocyte adhesion . Positive_regulation SELE TNF 18202320 1883809 FIR radiation also inhibited *mediated* expression of [E-selectin] , vascular cell adhesion molecule-1 , intercellular cell adhesion molecule-1 , monocyte chemoattractant protein-1 , interleukin-8 , and the cytokine mediated adhesion of monocytes to ECs . Positive_regulation SELE TNF 18250144 1911452 Moreover , the inhibitor prolonged *dependent* [E-selectin] induction , inhibited endothelial nitric oxide synthase expression at both mRNA ( quantitative real-time polymerase chain reaction ) and protein level ( enzyme linked immunosorbent assay and western blot ) , and lowered bioactive nitric oxide output ( RFL-6 reporter cell assay ) . Positive_regulation SELE TNF 18292233 1885515 In organ culture , *induced* expression of [E-selectin] , VCAM-1 , and ICAM-1 on HUVECs but only ICAM-1 on HUAECs . Positive_regulation SELE TNF 18292233 1885543 Transduction of HUVECs with KLF2 reduced *mediated* induction of [E-selectin] and VCAM-1 while increasing ICAM-1 induction and reduced transcription factor/co-activator binding to the E-selectin enhancer . Positive_regulation SELE TNF 18471997 1916661 Transfection in human aorta endothelial cells ( HAECs ) with these constructs revealed that the [E-selectin] promoter was sufficiently activated in *response* to , and miR-E1 and miR-E2 could suppress E-selectin expression resulting in the significant inhibition of leukocyte adhesion . Positive_regulation SELE TNF 18490752 1916992 LT failed to augment *induced* ICAM-1 or [E-selectin] expression , two adhesion molecules regulated by NF-kappaB , but not IRF-1 . Positive_regulation SELE TNF 19026699 2022740 Selective blockade of CRF-R1 resulted in significant increase in *induced* expression of vascular adhesion molecule-1 at mRNA level and [E-selectin] at mRNA and protein levels . Positive_regulation SELE TNF 19028529 2053485 Treatment of human aortic endothelial cells ( HAEC ) with 50 microM of Val-Pro-Leu , Ser-Ser-Ser and Glu-Glu-Glu inhibited *induced* monocyte adhesion and expression of the adhesion molecule [E-selectin] ( P < 0.05 ) . Positive_regulation SELE TNF 19138739 2037799 In addition , we determined the inhibitory effect of 1alpha,25- ( OH ) ( 2 ) D ( 3 ) on [E-selectin] expression *induced* by in HCAEC by flow cytometry . Positive_regulation SELE TNF 19138739 2037802 Moreover , flow cytometry revealed that pretreatment with 1alpha,25- ( OH ) ( 2 ) D ( 3 ) significantly inhibited the *induced* expression of [E-selectin] on HCAEC . Positive_regulation SELE TNF 19148111 2037982 ( 2 ) Digibind could attenuate and reduce *induced* upregulation of endothelial [E-selectin] , ICAM and VCAM expressions . Positive_regulation SELE TNF 19238330 2093608 By contrast , over-expression of a dominant negative SK inhibited the *induced* VCAM-1 and [E selectin] and inhibited PMN adhesion , confirming that the observed effects were specifically mediated by SK . Positive_regulation SELE TNF 19284655 2055709 The *induction* of the expression of endothelial VCAM-1 , ICAM-1 and [E-selectin] by was concentration-dependently reduced by incubation of the endothelial cells with the arginase inhibitor L-norvaline . Positive_regulation SELE TNF 19389799 2100746 These inhibitory responses of GW501516 on activated endothelium were accompanied by a reduction in *induced* endothelial GRO-alpha release and VCAM-1 , [E-selectin] , and ICAM-1 mRNA expression . Positive_regulation SELE TNF 19539051 2149496 HUVECs treated with alpha-iso-cubebene showed markedly suppressed *induced* mRNA expression of VCAM-1 and [E-selectin] , but little alteration in ICAM-1 mRNA expression . Positive_regulation SELE TNF 19539051 2149498 alpha-iso-Cubebene treatment also significantly decreased the *induced* cell surface and total protein expression of VCAM-1 and [E-selectin] without affecting ICAM-1 expression . Positive_regulation SELE TNF 19561137 2121981 We found that APN localizes to the luminal side of blood vessels in lung and acts in vitro to block *induced* [E-selectin] upregulation in pulmonary artery endothelial cells . Positive_regulation SELE TNF 19607809 2123915 OA-NO ( 2 ) and LNO ( 2 ) also blocked *induced* expression of the adhesion molecules , ICAM-1 , VCAM-1 , and [E-selectin] , and suppressed monocyte adhesion to HUVECs . Positive_regulation SELE TNF 19724926 2133997 We demonstrate here that extracts of A. alopecuroidea can inhibit *induced* [E-selectin] production , providing a mechanistic validation of its traditional use against inflammatory diseases . Positive_regulation SELE TNF 19878508 2293559 The objectives of this study were to : ( 1 ) determine the body composition , metabolic and inflammatory factors associated with increased E-selectin and ( 2 ) determine the *role* of in the physiological regulation of [E-selectin] by antagonism of TNF-alpha with etanercept among obese subjects . Positive_regulation SELE TNF 19878508 2293561 TNF-alpha antagonism with etanercept reduces E-selectin in obese subjects , providing evidence that the systemic circulatory release of [E-selectin] is *regulated* at least in part by in obesity . Positive_regulation SELE TNF 19905948 2161805 A cytokine inactivation assay that measured [E-selectin] expression in *response* to and IL-1 beta was developed to measure the ability of aPDT to inactivate cytokine function . Positive_regulation SELE TNF 19949084 2190696 Cutting edge : TNF induced microRNAs regulate *induced* expression of [E-selectin] and intercellular adhesion molecule-1 on human endothelial cells : feedback control of inflammation . Positive_regulation SELE TNF 20016245 2200098 The protein and mRNA levels of *induced* ICAM-1 , VCAM-1 and [E-selectin] were determined in HUVECs . Positive_regulation SELE TNF 20016245 2200103 These data suggested that the effect of puerarin mediated inhibition of *induced* ICAM-1 , VCAM-1 and [E-selectin] expression is attributed to suppressed NF-kappaB activation on the transcriptional level . Positive_regulation SELE TNF 20181103 2222761 This correlates with increased translocation of the transcription factor NF-kB to the nucleus , which is known to regulate ICAM-1 , VCAM-1 and [E-selectin] expression in *response* to . Positive_regulation SELE TNF 20378716 2273544 Real-time reverse transcription-polymerase chain reaction data demonstrated a significant inhibition of *induced* [E-selectin] mRNA levels after ES936 pretreatment . Positive_regulation SELE TNF 20378716 2273545 Immunoblot assays demonstrated a significant reduction in *stimulated* [E-selectin] , VCAM-1 , and ICAM-1 proteins after inhibition or knockdown of NQO1 . Positive_regulation SELE TNF 20465310 2268799 markedly *induced* protein expression of cell adhesion molecule and [E-selectin] with increasing mRNA levels in HUVEC . Positive_regulation SELE TNF 20484867 2276252 A JNK inhibitor , SP600125 , and a p38 inhibitor , SB203580 , inhibited *induced* [e-selectin] expression . Positive_regulation SELE TNF 20484867 2276254 An antioxidant drug , N-acetyl-L-cysteine (NAC) , inhibited *induced* [e-selectin] expression . Positive_regulation SELE TNF 20484867 2276261 Our results indicate that in ECs CV-159 specifically inhibits *induced* [e-selectin] expression through inhibition of JNK , p38 , and NF-kappaB phosphorylation . Positive_regulation SELE TNF 20554956 2285171 This increase was independent of alterations in *induced* expression of [E-selectin] , VCAM-1 , and ICAM-1 . Positive_regulation SELE TNF 20557886 2308775 Q-real-time PCR and protein array approaches confirmed that *induced* ICAM-1 , VCAM-1 and [ELAM-1] as well as MCP-1 and IL-6 induction was affected upon 3beta-Adiol pre-incubation . Positive_regulation SELE TNF 20558233 2302438 beta-sitosterol also significantly inhibited the *induced* expression of VCAM-1 and [E-selectin] , which also play key role in various inflammatory diseases . Positive_regulation SELE TNF 20579861 2339844 *induced* up-regulation of [E-selectin] was abrogated by pre-treatment of the cells with UA or OA which decreased expression of E-selectin mRNA . Positive_regulation SELE TNF 20621474 2296994 As a result , 7-O-cinnamoylmorroniside was observed to be a potent inhibitor of *induced* [E-selectin] expression . Positive_regulation SELE TNF 20851151 2368661 The effect of relaxin coincubation on the *stimulated* expression of the adhesion molecules VCAM-1 , ICAM-1 and [E-selectin] ; Positive_regulation SELE TNF 20878699 2326557 Preincubation with ATO ( 20 µg/mL ) suppressed *induced* expression of adhesion molecules including intercellular adhesion molecule-1 ( ICAM-1 ) , vascular cell adhesion molecule-1 ( VCAM-1 ) and [E-selectin] at both the protein and mRNA levels . Positive_regulation SELE TNF 20954188 2369333 [E-selectin] , a leukocyte adhesion molecule expressed on endothelium , is *induced* by and other cytokines involved in the pathogenesis of rheumatoid arthritis ( RA ) . Positive_regulation SELE TNF 20977376 2338620 One , ISIS9481 , exerted significant inhibition of [E-selectin] expression *induced* by + endotoxin [lipopolysaccharide (LPS) ] . Positive_regulation SELE TNF 21290470 2359935 Moreover , expression of [E-selectin] , IL-6 , and IL-8 was *induced* most efficiently by IL-1ß , while LPS and had less effect , whereas we did not find such a difference in ICAM-1 and MCP-1 expression . Positive_regulation SELE TNF 21437888 2475458 Stimulation of FucT-III transfected cells with recombinant human ( rh ) up-regulated sLeX expression and *increased* [E-selectin] binding . Positive_regulation SELE TNF 21445895 2443711 Immunoblot analysis showed that Monascus fermented rice metabolites significantly attenuated *induced* VCAM-1 and [E-selectin] but not ICAM-1 protein expression . Positive_regulation SELE TNF 21445895 2443714 Monascus fermented rice metabolites reduced *stimulated* endothelial adhesiveness as well as downregulating intracellular ROS formation , NF-?B activation , and [VCAM-1/E-selectin] expression in HAECs , supporting the notion that the various metabolites from Monascus fermented rice might have potential implications in clinical atherosclerosis disease . Positive_regulation SELE TNF 21626431 2454636 Indeed , levosimendan increased cyclic guanosine monophosphate ( cGMP ) in human umbilical vein endothelial cells ( HUVECs ) and impaired the *induced* inflammatory expression of [E-selectin] , intercellular adhesion molecule-1 ( ICAM-1 ) , cyclooxygenase-2 (COX-2) , and monocyte chemotactic protein-1 (MCP-1) . Positive_regulation SELE TNF 21876235 2473899 On the contrary , the *induction* of [E-selectin] by in ECs exposed to non-uniform shear stress was not affected by telmisartan . Positive_regulation SELE TNF 22019447 2513623 In endothelial cells exposed to non-uniform shear stress , VEGFR2 knockdown inhibited induced NF-?B translocation to the nucleus , and the *upregulation* of VCAM-1 and [E-selectin] . Positive_regulation SELE TNF 22895248 2647155 For example , activation of endothelial cells with cytokines like *results* in increased [E-selectin] and IL-8 expression . Positive_regulation SELE TNF 23800055 2802860 Furthermore , PF markedly blocked *induced* [E-selectin] and intercellular adhesion molecule-1 ( ICAM-1 ) expression in HDMECs at both mRNA and protein levels . Positive_regulation SELE TNF 23855486 2817022 Among 11 flavones , acacetin strongly inhibited *induced* [E-selectin] expression in HUVECs . Positive_regulation SELE TNF 23929007 2840713 Ectopic expression of aB-crystallin in endothelial cells increases the level of [E-selectin] expression in *response* to , and enhances leukocyte-endothelial interaction in vitro . Positive_regulation SELE TNF 23929007 2840715 Conversely , *induced* expression of intercellular adhesion molecule 1 , vascular cell adhesion molecule 1 and [E-selectin] is markedly inhibited in endothelial cells isolated from aB-crystallin-deficient mice . Positive_regulation SELE TNF 24316968 2894852 Carnosol not only inhibited *induced* protein expression of intercellular adhesion molecule (ICAM)-1 , vascular cell adhesion molecule (VCAM)-1 and [E-selectin] in HUVECs , but also suppressed interleukin (IL)-8 and monocyte chemoattractant protein (MCP)-1 expression . Positive_regulation SELE TNF 24329519 2921476 Monitoring of *induced* expression of the adhesion molecules VCAM-1 , ICAM-1 and [E-selectin] by flow cytometry was used to confirm NF-?B inhibition in endothelial cells , and thioglycollate induced peritonitis in mice to confirm effects in vivo . Positive_regulation SELE TNF 24329519 2921478 Plumericin inhibited NF-?B mediated transactivation of a luciferase reporter gene ( IC50 1 µM ) , abolished *induced* expression of the adhesion molecules VCAM-1 , ICAM-1 and [E-selectin] in endothelial cells and suppressed thioglycollate induced peritonitis in mice . Positive_regulation SELE TNF 7504714 244323 ICAM-1 , VCAM-1 , and [E-selectin] were all *induced* by dsRNA ( poly ( I:C ) ) , IL-1 beta , , and LPS in KS cells . Positive_regulation SELE TNF 7504889 237477 In contrast , [ELAM-1] *induction* by is only inhibited by anti-p55 . Positive_regulation SELE TNF 7517980 261801 Thus , UVB selectively upregulates ICAM-1 , but not [E-selectin] or VCAM-1 , mRNA and cell surface expression in HDMEC , and this upregulation is not *dependent* upon the autologous secretion and activity of either IL-1 or . Positive_regulation SELE TNF 7518452 261868 We reported previously that cAMP actually decreases [ELAM-1] synthesis *induced* by . Positive_regulation SELE TNF 7521751 243710 In contrast to the observed reduction of VCAM-1 mRNA accumulation and surface protein expression , inhibition of topoisomerase II activity enhanced [E-selectin] mRNA accumulation and surface protein expression in *response* to stimulation of HUVE . Positive_regulation SELE TNF 7526034 277073 CD34 expression of this cell line and the ability of transforming growth factor-beta to inhibit the *induction* of [E-selectin] was examined . Positive_regulation SELE TNF 7526034 277074 The ability of interleukin-4 to enhance the expression of VCAM and reduce the *mediated* expression of [E-selectin] is maintained in this cell line . Positive_regulation SELE TNF 7534264 296899 Immunocytochemistry of frozen sections from sponges showed that [E-selectin] expression was *up-regulated* markedly by and PHA at 5 hr , only moderately by IL-1 alpha at 5 hr , and not at all by PMA at 5 hr . Positive_regulation SELE TNF 7534663 296993 The *induction* of vascular cell adhesion molecule-1 ( VCAM-1 ) and [E-selectin] by is mediated by mobilization of the transcription factor nuclear factor-kappa B (NF-kappa B) . Positive_regulation SELE TNF 7536438 297251 *induced* endothelial [E-selectin] , intercellular adhesion molecule-1 ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) in all groups , and adhesion molecule expression by interstitial dermal dendritic cells ( ICAM-1 and VCAM-1 ) and keratinocytes ( ICAM-1 ) was observed . Positive_regulation SELE TNF 7537468 300906 *induces* [E-selectin] production in splanchnic artery occlusion shock . Positive_regulation SELE TNF 7537508 287874 IL-1 beta and *increased* the expression of [E-selectin] on the cytoplasmic membranes of HUVECs , HSVECs and HAFECs and elicited even similar absolute quantities of this molecule , comparing the different cell types . Positive_regulation SELE TNF 7538441 301307 Here , we show that peptide aldehyde inhibitors of the proteasome , a multicatalytic protease recently shown to be required for the activation of NF-kappa B , block *induction* of the leukocyte adhesion molecules [E-selectin] , VCAM-1 , and ICAM-1 . Positive_regulation SELE TNF 7541425 310489 *Induction* of VCAM-1 and [ELAM-1] surface expression by was dose-dependently reduced by pretreatment with the protein tyrosine kinase inhibitors herbimycin A ( HMA , IC50 300 nM ) or genistein ( IC50 30 microM ) . Positive_regulation SELE TNF 7541425 310493 Our data suggest that specific phosphorylation following protein tyrosine kinase activation may be required for NF-kappa B mobilization and *induction* of VCAM-1 and [ELAM-1] by . Positive_regulation SELE TNF 7543521 314315 Enhancement by the complement membrane attack complex of *induced* endothelial cell expression of [E-selectin] and ICAM-1 . Positive_regulation SELE TNF 7543521 314317 This conclusion was further supported by a whole-cell ELISA , which provided evidence that the MAC augments *induced* up-regulation of both [E-selectin] and ICAM-1 . Positive_regulation SELE TNF 7578984 333394 The current study was undertaken to investigate the *role* of in regulation of [E-selectin] and ICAM-1 expression by TNF on HUVEC . Positive_regulation SELE TNF 7578984 333398 In contrast , both MR2-1 and pAb75 inhibited specifically *induced* [E-selectin] and ICAM-1 expression , but not activation by IL-1 or LPS . Positive_regulation SELE TNF 7583580 333554 Steady state mRNA levels of *induced* VCAM-1 and [E-selectin] are significantly reduced by physiological concentrations of HDLs . Positive_regulation SELE TNF 7684420 217586 Unexpectedly , this combination of cAMP elevating drugs inhibits *induction* of [ELAM-1] and VCAM-1 but not ICAM-1 expression . Positive_regulation SELE TNF 7684420 217589 Forskolin plus IBMX selectively inhibits *induced* increases in [ELAM-1] and VCAM-1 mRNA , indicating that the action of cAMP is to block synthesis of these molecules . Positive_regulation SELE TNF 7684420 217590 However , our findings suggest that pharmacological elevations of cAMP in EC , by inhibiting *induced* synthesis of [ELAM-1] and VCAM-1 , could serve to limit inflammation . Positive_regulation SELE TNF 7691964 231048 Endothelial-leukocyte adhesion molecule-1 ( [ELAM-1] ) expression *induced* at 6 and 24 h by or IL-1 , is restricted to the venular side of the capillary loop and to the venules proper . Positive_regulation SELE TNF 7691964 231055 These results with DMEC differ from human umbilical vein EC analyzed in parallel , which are completely CD36- and show transient [ELAM-1] and sustained VCAM-1 expression in *response* to and IL-1 . Positive_regulation SELE TNF 7693806 234197 Venous and arterial large vessel endothelial cells ( EC ) were compared for their constitutive and *induced* expression of the cell-surface adhesion molecules ICAM-1 and -2 , VCAM-1 and [ELAM-1] by FACS analysis . Positive_regulation SELE TNF 7693806 234199 increases the expression of ICAM-1 , but not ICAM-2 , and *induces* the expression of [ELAM-1] on both EC types . Positive_regulation SELE TNF 7962270 279357 Expression of [E-selectin] on endothelial cells was *induced* only by IL-1 alpha , not by IFN gamma or . Positive_regulation SELE TNF 8100455 222530 Exposure of HUVEC to perflubron did not alter the upregulation of ICAM or [ELAM] in *response* to IL-1 or ( n = 20 ) . Positive_regulation SELE TNF 8194873 259001 *induced* increased expression of [ELAM-I] and VCAM-I adhesion molecules on intratumoral endothelial cells . Positive_regulation SELE TNF 8356403 227512 also *induced* [E-selectin] expression on EA-hy-926 and HUVEC and an accompanying increase in neutrophil ( PMN ) binding . Positive_regulation SELE TNF 8390537 220627 All four treatments also inhibited *induced* surface expression of [ELAM-1] by 50 to 100 % . Positive_regulation SELE TNF 8534616 331222 We have demonstrated that stimulation of HDMEC with IL-1 alpha or *leads* to transient [E-selectin] induction which disappears after 48 h , but stimulation of HDMEC with IFN-gamma resulted in delayed E-selectin induction which was seen at 48 h of incubation and persisted until 72 h after stimulation . Positive_regulation SELE TNF 8568264 350971 In the lungs , but not in other organs , transient [E-selectin] expression was *induced* by within 0.5 h and peaked at 4 h . Positive_regulation SELE TNF 8568264 350973 The *induced* expression of VCAM-1 and [E-selectin] was found to be exclusively controlled by the 55-kDa TNF-receptor ( TNFRp55 ) as demonstrated by analysis of TNFRp55-/- mice . Positive_regulation SELE TNF 8568264 350977 Together , the data suggest that in vivo the 55-kDa receptor *mediates* the induction of VCAM-1 and [E-selectin] expression and is critically involved in the control of leukocyte organ infiltration . Positive_regulation SELE TNF 8575077 350035 Furthermore , inhibition *prevented* the upregulation of lung tissue IL-1 beta , IL-6 , cytokine induced neutrophil chemoattractant , and [E-selectin] ( ELAM-1 ) but not intercellular adhesion molecule-1 mRNAs in response to IL-2 . Positive_regulation SELE TNF 8579110 350453 Locally produced interleukin-1 and *induced* vascular cellular adhesion molecule-1 ( VCAM-1 ) and [E-selectin] on tumor vessels . Positive_regulation SELE TNF 8666424 369080 but not the other human cytokines unregulated swine leucocyte antigens (SLA) class I , class II and B7 receptor expression and *induced* vascular cell adhesion molecule ( VCAM ) and [E-selectin] expression . Positive_regulation SELE TNF 8673632 343149 alone *induces* the endothelial release of Interleukin-8 (Il-8) as well as the expression of P- and [E-selectin] . Positive_regulation SELE TNF 8690082 370543 Inhibition of thrombin induced p42 mapk activation was paralleled by an inhibitory effect of PD98059 on thrombin-driven PG12 generation but not on vWF secretion or IL-1 *induced* [E-selectin] expression . Positive_regulation SELE TNF 8695814 372862 Also , the *induction* of vascular EC adhesion molecule-1 (VCAM-1) and [E-selectin] by was significantly inhibited by prior exposure to bFGF . Positive_regulation SELE TNF 8729095 373990 In further studies , DHA dose- and time-dependently reduced also the expression of [E-selectin] , Intercellular Adhesion Molecule-1 , interleukin (IL)-6 and IL-8 , in *response* to IL-1 , IL-4 , , or bacterial endotoxin . Positive_regulation SELE TNF 8739563 377097 We demonstrate that the PTK inhibitors herbimycin A or genistein suppress *induction* of endothelial VCAM-1 and [E-selectin] , as well as subsequent monocytic cell adhesion to endothelial cells stimulated by . Positive_regulation SELE TNF 8751905 377220 With Escherichia coli LPS , alpha activation requires membrane bound CD14 and [E-selectin] expression *requires* soluble CD14 ( sCD14 ) . Positive_regulation SELE TNF 8780174 380054 The expression of [E-selectin] *induced* by on the surface of human umbilical vein endothelial cells ( HUVEC ) was partially inhibited by an increase in the level of adenosine 3',5'-cyclic monophosphate ( cAMP ) , produced by forskolin or cholera toxin combined with the type IV phosphodiesterase inhibitor rolipram and the protein kinase A agonist phosphorothioate analogue of cAMP SpcAMPS . Positive_regulation SELE TNF 8780174 380056 In addition to their partial inhibitory effect on the *induced* surface expression of [E-selectin] on HUVEC , the forskolin-rolipram combination and SpcAMPS strongly inhibited the release of soluble E-selectin from these cells ; Positive_regulation SELE TNF 8797629 381379 *induced* [E-selectin] expression on vascular endothelial cells . Positive_regulation SELE TNF 8797629 381382 Blocking of either CD120a or CD120b receptors individually resulted in inhibition of *induced* [E-selectin] expression on human umbilical vein endothelial cells . Positive_regulation SELE TNF 8797629 381385 When both antibodies were added , the inhibition of *induced* [E-selectin] expression was synergistic . Positive_regulation SELE TNF 8797629 381387 Both CD120a and CD120b receptors are involved in *induced* [E-selectin] expression on human umbilical vein endothelial cells . Positive_regulation SELE TNF 8797629 381392 Blocking of both or one receptor type can reduce or totally inhibit expression of [E-selectin] on human umbilical vein endothelial cells , but the response is *dependent* on both and antibody concentrations . Positive_regulation SELE TNF 8806799 382668 Histamine enhanced the *induced* expression of [E-selectin] and ICAM-1 on vascular endothelial cells . Positive_regulation SELE TNF 8806799 382670 *induces* the expression of [E-selectin] and intercellular adhesion molecule-1 ( ICAM-1 ) on human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation SELE TNF 8806799 382736 In this report , we show that histamine concentration-dependently enhances the *induced* expression of [E-selectin] and ICAM-1 on HUVEC . Positive_regulation SELE TNF 8838134 386551 The [ELAM] *inducing* activity of pure , however , was about 1/2 that of BALF60 containing equivalent concentrations of TNF alpha . Positive_regulation SELE TNF 8838134 386552 The time courses for ICAM and [ELAM] *stimulation* with pure or BALF60 containing equivalent levels of TNF alpha were the same . Positive_regulation SELE TNF 8842442 387273 Although similar effects were seen on phorbol 12-myristate , 13-acetate ( PMA ) -induced expression , this was not due to inhibition of protein kinase C ( PKC ) activity as the selective inhibitors of PKC , bisindolylmaleimide ( BIM ) , Ro31-7549 or Ro31-8220 did not affect IL-1 alpha- or *induced* [E-selectin] expression at concentrations which maximally inhibited PMA induced expression . Positive_regulation SELE TNF 8843727 387422 ( TNF-alpha ; 10 ng/ml ) *increased* endothelial ICAM-1 , [E-selectin] , and VCAM-1 ; Positive_regulation SELE TNF 8866792 344794 In previous studies we have shown that IL-1 beta and *increase* the expression of ICAM-1 , [E-selectin] and VCAM-1 on the cytoplasmatic membranes of HUVECs , HSVECs and HAFECs ( ECs from human umbilical vein , saphenous vein and femoral artery , respectively ) . Positive_regulation SELE TNF 8871646 389580 *induction* of the [E-selectin] and vascular cell adhesion molecule-1 ( VCAM-1 ) genes leads to transient accumulation of high levels of mRNA in endothelial cells . Positive_regulation SELE TNF 8902648 393872 UVB radiation suppresses the *induced* expression of [E-selectin] and ICAM-1 on cultured human umbilical vein endothelial cells . Positive_regulation SELE TNF 8906207 394113 When supernatants of alveolar macrophages , recovered from patients exhibiting a late asthmatic response after allergen exposure , were tested on HUVEC cultures , a *dependent* ICAM-1 and [E-selectin] overexpression was observed . Positive_regulation SELE TNF 8943958 400205 treatment *induces* expression of [E-selectin] and increases expression of P-selectin on endothelial cells . Positive_regulation SELE TNF 9012737 411078 This fatty acid induced inhibitory activity was reflected in the ability of the mediators to decrease the *induced* expression of the following endothelial adhesion molecules : intercellular adhesion molecule-1 ( ICAM-1 ) , [E-selectin] , and vascular cell adhesion molecule-1 ( VCAM-1 ) , measured by both enzyme linked immunosorbent assay and flow cytometric analysis . Positive_regulation SELE TNF 9022083 413239 To determine modes of retinoid action in the modulation of inflammatory responses , we explored effects of all-trans-retinoic acid ( t-RA ) on the *induced* expression of vascular cell adhesion molecule-1 ( VCAM-1 ) , intercellular adhesion molecule-1 ( ICAM-1 ) , and [E-selectin] in cultured human dermal microvascular endothelial cells . Positive_regulation SELE TNF 9022083 413242 Pretreatment with t-RA specifically prevented *induced* VCAM-1 expression , but not ICAM-1 and [E-selectin] induction . Positive_regulation SELE TNF 9030094 413756 Failure to block biosynthesis of [E-selectin] and ICAM-1 *induced* by and IL-1 beta indicates the inhibitory effect exerted by serotonin was selective in nature . Positive_regulation SELE TNF 9039934 415824 Soluble tumor necrosis factor (TNF) alpha receptor inhibited [E-selectin] *induced* by , but not by U937 cells , and mRNA and protein on EC in Mo-EC mixtures cocultured at 1 : 1 ratios were not significantly reduced . Positive_regulation SELE TNF 9039934 415825 The inhibitor did *reduce* [E-selectin] expression ( 30-40 % ) , as well as induced chemokine gene expression ( 80 % ) , at higher Mo-EC ratios . Positive_regulation SELE TNF 9164965 432156 Although IL-1 and also *induce* IL-8 and [E-selectin] , the thrombin effects in these experiments were not mediated by those cytokines , since neither IL-1 receptor antagonist nor anti-TNF-alpha Ab inhibited the effects of thrombin . Positive_regulation SELE TNF 9209275 441014 TBP I completely abolished *induced* IL-6 production and [E-selectin] induction , while it partially inhibited TNF induced IL-8 production and up-regulation of ICAM-1 and VCAM-1 . Positive_regulation SELE TNF 9234165 445253 The IC50 for the *induced* [ELAM-1] and ICAM-1 expressions were 1.5 x 10 ( -5 ) M and 3.1 x 10 ( -5 ) M , respectively . Positive_regulation SELE TNF 9234165 445255 In addition , protein C-kinase ( PKC ) inhibitor H7 also inhibited the [ELAM-1] and ICAM-1 expressions *induced* by IL-1 beta and . Positive_regulation SELE TNF 9277478 450779 TCP succinate ( 200 microM , 24 h ) reduced *induced* VCAM-1 and [E-selectin] expression from a specific mean fluorescence intensity of 151 +/- 28 to 12 +/- 4 channels and from 225 +/- 38 to 79 +/- 21 channels , respectively . Positive_regulation SELE TNF 9317150 456267 *initiates* [E-selectin] transcription in human endothelial cells through parallel TRAF-NF-kappa B and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways . Positive_regulation SELE TNF 9317150 456272 Transient overexpression of N-terminal truncated c-Jun or catalytically inactive Jun N-terminal kinase (JNK) 1 and 2 inhibits *induced* transcription of an [E-selectin] but not a kappa B promoter-reporter gene . Positive_regulation SELE TNF 9317150 456273 Transient overexpression of the TRAF2 adaptor protein can activate NF-kappaB and endogenous JNK , whereas N-terminal truncated TRAF2 protein blocks *induced* NF-kappa B and JNK activation as well as [E-selectin] promoter-reporter gene transcription . Positive_regulation SELE TNF 9317150 456283 Transient overexpression of RAC1 or CDC42 , but not RAS , constitutively activates JNK and augments *induced* [E-selectin] transcription . Positive_regulation SELE TNF 9351830 466076 Microinjection of the inhibitory peptides into stimulated cells abolished NF-kappa B activation in *response* to and the consequent expression of [E-selectin] , an NF-kappa B-dependent cell-adhesion molecule . Positive_regulation SELE TNF 9366433 463252 A dual radiolabeled mAb technique was used to quantify constitutive and *induced* expression of ICAM-1 , VCAM-1 , [E-selectin] , and P-selectin in different vascular beds ( lung , heart , stomach , mesentery , small intestine , large intestine , and muscle ) in wild-type and SCID mice . Positive_regulation SELE TNF 9371591 464203 significantly *enhanced* WNV induced increases in [E-selectin] , P-selectin , ICAM-1 , and VCAM-1 expression , while IFN-gamma enhanced WNV induced ICAM-1 expression . Positive_regulation SELE TNF 9378988 465721 The inhibitory effect of IFN-gamma on poly ( I:C ) -induced E-selectin was concentration and time dependent and was specific for dsRNA , in that the *induction* of [E-selectin] by , IL-1 beta , thrombin , or LPS was not inhibited significantly by this pretreatment . Positive_regulation SELE TNF 9421277 472479 5. The data demonstrate that apart from its antiproliferative effects on lymphocytes , MPA enhances *induced* VCAM-1 and [E-selectin] surface expression on EC by selectively increasing the mRNA-stability of these cell adhesion molecules . Positive_regulation SELE TNF 9448041 483774 and IL-1beta *increased* the expression of ICAM-1 , [E-selectin] , and VCAM-1 , whereas IL-4 induced only that of VCAM-1 . Positive_regulation SELE TNF 9486659 488351 We have generated populations of endothelial cells expressing wild-type and a proteolysis-resistant mutation of IkappaB that is lacking the 36 N-terminal amino acids ( IkappaBdeltaN ) in order to examine the effects of expression of the mutated IkappaB on *induced* [E-selectin] and ICAM-1 expression . Positive_regulation SELE TNF 9488215 476499 The addition of lacidipine to human umbilical vein endothelial cells significantly reduced the expression of ICAM-1 , VCAM-1 and [E-selectin] *induced* by alone or with oxidized LDL ( P < 0.001 ) . Positive_regulation SELE TNF 9548505 477735 However , thrombin ( 3-10 U/ml ) stimulated a 10-fold enhancement in the ability of ( 0.3-1.0 ng/ml ) to *induce* [E-selectin] surface expression . Positive_regulation SELE TNF 9548505 477736 Similar potentiation of *induced* NF-kappaB activity and [E-selectin] transcription by thrombin was observed in experiments utilizing luciferase reporter constructs expressed in bovine aortic EC . Positive_regulation SELE TNF 9590504 504816 *induced* expression of [E-selectin] was similar in cells at Passages 3 , 6 , and 12 , indicating that the cells maintained responsiveness to cytokines over several weeks . Positive_regulation SELE TNF 9620666 510564 The NO donors , but not 8-bromo-cGMP , decreased *induced* VCAM-1 , ICAM-1 , and [E-selectin] expression by 11-70 % . Positive_regulation SELE TNF 9630364 512341 3. Rolipram in combination with salbutamol , but neither agent alone , inhibited *induced* [E-selectin] expression , whilst ICAM-1 and VCAM-1 expression were not affected . Positive_regulation SELE TNF 9632524 512699 Among them , [E-selectin] , which is expressed in *response* to interleukin 1 (IL-1) or , provides rolling adhesion of the circulating leukocytes , a transient and reversible interaction that initiates leukocyte extravasation . Positive_regulation SELE TNF 9680172 520993 These two GPx mimics were also found to be the most efficient inhibitors of the *induced* endothelial expression of P- and [E-selectin] and of the TNFalpha- or interleukin1 induced endothelial release of interleukin-8 . Positive_regulation SELE TNF 9699892 525170 Finally , apo E-DMPC vesicles were also unable to suppress *induced* upregulation of [E-selectin] or intercellular adhesion molecule-1 ( ICAM-1 ) . Positive_regulation SELE TNF 9728048 530023 These findings indicate that *induces* NF-kappaB activation and the resultant [E-selectin] gene expression by a pathway that involves formation of ROS and that E-selectin expression can be inhibited by the antioxidant action of NAC or PDTC . Positive_regulation SELE TNF 9769910 538762 *initiates* transcription of the [E-selectin] gene by activation of the transcription factors NF-kappa B and c-Jun/ATF-2 . Positive_regulation SELE TNF 9791729 542510 A neutralizing anti-TNF monoclonal antibody ( cA2 ) was used to study the down regulation of *induced* [E-selectin] , vascular cell adhesion molecule-1 ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ) on cultured human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation SELE TNF 9837893 552471 Using highly specific antisense oligonucleotides that target the mRNA encoding c-Raf kinase and Ha-Ras , we show here that inhibition of c-raf and Ha-ras expression blocks the up-regulation of [E-selectin] and vascular adhesion molecule-1 *induced* by in endothelial cells . Positive_regulation SELE TNF 9837893 552474 Furthermore , antisense inhibition of JNK2 also blocked *mediated* induction of [E-selectin] , whereas PD98059 ( mitogen activated protein kinase kinase 1 and 2 inhibitor ) had no effect on this process . Positive_regulation SELE TNF 9837893 552476 These results indicate that *induction* of [E-selectin] and vascular adhesion molecule-1 in endothelial cells occurs through signaling pathways that are , at least in part , dependent on c-Raf kinase , Ha-Ras , and JNK2 . Positive_regulation SELE TNF 9852915 554833 As measured with the use of an enzyme linked immunosorbent assay , , IL-1 , and LPS each *induced* a significant increase in surface expression of [E-selectin] in cultured human umbilical vein endothelial cells ( HUVECs ) compared with HUVECs treated with medium alone . Positive_regulation SELE TNF 9887050 584958 *stimulated* expression of both intercellular adhesion molecule-1 and [E-selectin] in HUVECs , but in HUAECs , only intercellular adhesion molecule-1 was increased . Positive_regulation SELE TNFSF10 12874246 1114996 In surviving cells , activates NF-kappaB , *induces* expression of [E-selectin] , ICAM-1 , and IL-8 , and promotes adhesion of leukocytes . Positive_regulation SELL ABL1 21277237 2398197 *Role* of in [L-selectin] shedding from the neutrophil surface . Positive_regulation SELL ACE 1731039 181342 and 7 ) [Leu8-ANGI] is a highly potent antagonist infused either IMA or i.v. , and its antagonist properties do not *require* . Positive_regulation SELL ADAM17 16735599 1612376 In addition , the absence of functional *resulted* in significantly increased levels of [L-selectin] surface expression by peripheral-blood leukocytes , indicating the sheddase also plays a role in the constitutive cleavage of L-selectin . Positive_regulation SELL AGO2 15137490 1246140 Likewise , M. bovis stimulation of lymphocytes from vaccinated deer *resulted* in increases in CD44 expression and decreases in [CD62L] expression . Positive_regulation SELL ALB 7515857 257297 Presence of human *reduced* the down-regulation of [L-selectin] on both monocytes and neutrophils but to a greater extent on monocytes . Positive_regulation SELL ANG 19837408 2224670 The present work was undertaken to investigate whether *regulates* the expression of [CD62L] on human neutrophils . Positive_regulation SELL C5 7537984 301110 *increased* the expression of CD18 ( the common subunit of beta 2 integrins ) on PMN by nearly twofold and decreased levels of [L-selectin] by 50 % within 15 minutes after administration . Positive_regulation SELL CA2 9087605 421674 Cross linking of canine neutrophil [L-selectin] using anti-L-selectin antibody *induced* a rapid and transient increase in intracellular levels and superoxide anion generation that were dependent on the extent of L-selectin cross linking . Positive_regulation SELL CALM3 9529256 496576 *regulates* [L-selectin] adhesion molecule expression and function through a protease dependent mechanism . Positive_regulation SELL CCL2 1348518 182830 In this study , immunofluorescence flow cytometry was used to determine whether can *regulate* the cell surface expression of adhesion molecules , particularly beta-2 and alpha-4 integrins and the [leukocyte adhesion molecule-1] . Positive_regulation SELL CD2 8603434 352180 Analysis of expression of other adhesion molecules demonstrated that CD11a , CD18 , CD44 , CD45 , CD48 , CD54 , and [CD62L] were significantly *increased* by either or anti-CD3 mAbs while the combination was not synergistic . Positive_regulation SELL CD2 8821628 344547 Expression of other integrin , selectin , or immunoglobulin superfamily molecules ( CD11a , CD18 , CD44 , CD45 , CD48 , CD54 and [CD62L] ) were all significantly *increased* by or anti-CD3 mAbs . Positive_regulation SELL CD36 7506497 239655 In an immunohistologic study , [endothelial-leukocyte adhesion molecule-1] ( ELAM-1 ) was not *detected* in group I after treatment with artesunate , although the presence of , thrombospondin , intercellular adhesion molecule-1 , IgG , and C3 in the cerebral microvessels was not altered . Positive_regulation SELL CD4 10449768 637399 Because CD4 is a coreceptor for HIV-1 , the down-regulation of [L-selectin] *induced* by ligation could play a role in the pathogenesis of AIDS . Positive_regulation SELL CD44 18391078 1944192 Our data indicate that , although PSGL-1 has a partial role in the transmigration of monocytes into the inflamed retina , [CD62L] has a key role in regulating recruitment of monocytes to lymphoid tissue from the blood during inflammation and that is *required* to maintain CD62L ( + ) inflammatory monocytes within the circulation during inflammation . Positive_regulation SELL CDC73 9163638 432101 Concentration dependent inhibition of the *induced* CD11b expression and [L-selectin] shedding for neutrophils and eosinophils was observed with rolipram , dibutyryl cyclic adenosine monophosphate ( cAMP ) , prostaglandin E2 ( PGE2 ) , and isoproterenol . Positive_regulation SELL CDC73 9379058 465848 Stimulation through [L-selectin] *induced* membrane ruffling , whereas or IL-8 induced bipolar shape change . Positive_regulation SELL CHST4 10435581 634285 *enhances* [L-selectin] mediated adhesion under shear compared to nonsulfated controls . Positive_regulation SELL CR1 16600024 1556430 F-met-leu-phe *increased* CD11b , CD35 and CD18 and decreased [CD62L] expression in all groups , with a greater increase in severe asthma . Positive_regulation SELL CSF2 1694883 135322 Granulocyte-macrophage and other cytokines *regulate* surface expression of the [leukocyte adhesion molecule-1] on human neutrophils , monocytes , and their precursors . Positive_regulation SELL CSF2 1694883 135325 Interestingly , and IFN-gamma *had* minimal effects on neutrophil [LAM-1] expression . Positive_regulation SELL CSF2 9008610 410850 Pretreatment of neutrophils with either NSAID prevented the changes in [L-selectin] and CD11b expression *induced* by TNF alpha , , and FMLP , but not those induced by PMA or A23187 . Positive_regulation SELL CTR9 9163638 432102 Concentration dependent inhibition of the *induced* CD11b expression and [L-selectin] shedding for neutrophils and eosinophils was observed with rolipram , dibutyryl cyclic adenosine monophosphate ( cAMP ) , prostaglandin E2 ( PGE2 ) , and isoproterenol . Positive_regulation SELL CTR9 9379058 465849 Stimulation through [L-selectin] *induced* membrane ruffling , whereas or IL-8 induced bipolar shape change . Positive_regulation SELL CTSG 21860019 2490883 Using knockout mice and blocking antibodies , we found that mucin triggered release *requires* [L-selectin] and PSGL-1 on neutrophils , P-selectin on platelets , and Src family kinases in both cell types . Positive_regulation SELL CXCR4 21460863 2448201 Our findings show that surface levels on neutrophils *increase* after extravasation into injured lungs , possibly through the activation of [L-selectin] . Positive_regulation SELL F2R 11458449 838363 Thrombin and agonist peptide *induced* endothelial [leukocyte adhesion molecule-1] ( ELAM-1 ) expression . Positive_regulation SELL FCGR3B 9378982 465716 Despite the 5- to 10-fold greater expression and engagement at saturation , activation via *led* to little or no change in [L-selectin] expression . Positive_regulation SELL FOXO1 18713968 1950749 *regulates* [L-Selectin] and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase . Positive_regulation SELL FOXO1 23133314 2696554 Significantly , binds to a FOXO1 motif , CCCTTTGG , at -87/-80 , and *transactivates* the [L-selectin] promoter in a dose dependent manner . Positive_regulation SELL FOXO1 23133314 2696555 Over-expression of a constitutive-active *increased* the endogenous [L-selectin] expression in Jurkat cells . Positive_regulation SELL FOXO1 23133314 2696556 We conclude that *regulates* [L-selectin] expression through targeting its promoter . Positive_regulation SELL FUT4 11485743 844906 also *contributes* to HEV-born [L-selectin] ligands , since lymphocyte homing retained in FucT-VII ( -/- ) mice is revoked in FucT-IV ( -/- ) /FucT-VII ( -/- ) mice . Positive_regulation SELL FUT4 11485743 844907 These observations reveal essential *dependent* contributions to E- , P- , and [L-selectin] ligand synthesis and to the control of leukocyte recruitment and lymphocyte homing . Positive_regulation SELL FUT4 14597733 1160942 Intravital microscopy experiments revealed that MECA-79-reactive ligands depend primarily on FucT-VII , whereas MECA-79 independent medullary [L-selectin] ligands are *regulated* by . Positive_regulation SELL FUT4 15579466 1368533 Here we have examined the *role* of human and -VII in conferring [L-selectin] , P-selectin , and E-selectin binding activities to PSGL-1 . Positive_regulation SELL FUT7 12403782 1036141 Simultaneous expression of core-2 beta1,6-N-acetylglucosaminyltransferase and was *required* for optimal [L-selectin] binding to PSGL-1 . Positive_regulation SELL FUT7 15579466 1368534 Here we have examined the *role* of human in conferring [L-selectin] , P-selectin , and E-selectin binding activities to PSGL-1 . Positive_regulation SELL FUT7 9892607 586672 Cytokine activation of human umbilical vein endothelial cells ( HUVEC ) also *induced* functional [L-selectin] ligand expression , with increased CLA expression and transcription . Positive_regulation SELL GCNT2 12403782 1036142 Simultaneous expression of core-2 and fucosyltransferase VII was *required* for optimal [L-selectin] binding to PSGL-1 . Positive_regulation SELL GRAP2 18332130 1898159 In addition , ligation of [L-selectin-c] and L-selectin-v1 , but not L-selectin-v2 , *induced* mitogen activated protein kinase phosphorylation . Positive_regulation SELL HRAS 11479463 842263 These findings suggest that AT1 receptor antagonism selectively modulates L-selectin expression on leukocytes and that endogenous stimulation of AT1 receptors by the *contributes* to the activation of leukocytes and decreased expression of [L-selectin] in CAD . Positive_regulation SELL HRAS 8986819 404094 Stimulation of the Ras pathway by L-selectin requires functional p56lck , since p56lck-deficient Jurkat cells ( JCaM1.6 ) do not show tyrosine phosphorylation , association of [L-selectin] with Grb2/Sos , and *activation* of upon L-selectin triggering . Positive_regulation SELL HRAS 9070897 419809 This actin polymerisation is mediated by a Ras and Rac2 regulated pathway , since inhibition of by transient transfection of transdominant inhibitory N17Ras or suppression of Rac2 protein expression by antisense oligonucleotides *prevents* [L-selectin] triggered actin polymerisation . Positive_regulation SELL ICAM1 7506497 239656 In an immunohistologic study , [endothelial-leukocyte adhesion molecule-1] ( ELAM-1 ) was not *detected* in group I after treatment with artesunate , although the presence of CD36 , thrombospondin , , IgG , and C3 in the cerebral microvessels was not altered . Positive_regulation SELL ICAM1 7513985 253912 was upregulated , and endothelial [leukocyte adhesion molecule 1] was *induced* on superficial dermal blood vessels . Positive_regulation SELL ICAM1 8464084 215934 Surprisingly , expression of adhesion molecules endothelial [leukocyte adhesion molecule-1] and vascular cell adhesion molecule were not elevated , but expression did *increase* in more severely diseased skin . Positive_regulation SELL IFNG 10561528 566853 Surprisingly , stimulation with TNFalpha , and IL-1beta also *induced* the expression of [L-selectin] on fetal and diabetic Schwann cells , but not on normal adult cells . Positive_regulation SELL IFNG 1375697 188213 Interleukin 4 ( 1 ng/ml ) and ( 100 U/ml ) also *increased* surface [LAM-1] levels on these cells to 218 +/- 119 % ( n = 8 , p less than 0.001 ) and 245 +/- 116 % ( n = 5 , p less than 0.001 ) of control levels respectively . Positive_regulation SELL IFNG 1694883 135326 Interestingly , granulocyte-CSF and *had* minimal effects on neutrophil [LAM-1] expression . Positive_regulation SELL IFNG 7538427 301289 In parallel , DHA inhibited TNF-alpha stimulated monocytic U937 cell adhesion to HUVECs but did not affect TNF-alpha- or induced expression of intercellular adhesion molecule-1 and endothelial [leukocyte adhesion molecule-1] or VCAM-1 *induction* by interleukin-1 beta . Positive_regulation SELL IL10 15573087 1344494 However , gene profile analysis showed that *increased* the expression of cell migration related genes ( eg [L-selectin] , vascular endothelium growth factor receptor-1 , plasminogen activator , tissue ; formyl peptide receptor , lipoxin A4 receptor ) , which might support a stimulatory effect not evident with the in vitro functional assay . Positive_regulation SELL IL10 8392131 224751 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL10 8582548 341265 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL10 9647249 514973 NK activation by PMA , IL-2 , IL-15 , or TGF-beta down-regulated L-selectin on the CD56bright subset , while increased [L-selectin] levels were observed in both the CD56bright and CD56dim NK subsets in *response* to IL-12 , , or IFN-alpha . Positive_regulation SELL IL11 8392131 224752 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL11 8582548 341266 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL12A 10415016 631139 Expression of [L-selectin] on Th1 cells is *regulated* by . Positive_regulation SELL IL12A 10415016 631143 Given the key role played by IL-12 in the differentiation of naïve T cells into the Th1 subset , the observation that can also *regulate* [L-selectin] expression has implications for the migration of Th1 effector cells both through the lymphatic system and to sites of inflammation . Positive_regulation SELL IL12A 9647249 514974 NK activation by PMA , IL-2 , IL-15 , or TGF-beta down-regulated L-selectin on the CD56bright subset , while increased [L-selectin] levels were observed in both the CD56bright and CD56dim NK subsets in *response* to , IL-10 , or IFN-alpha . Positive_regulation SELL IL12B 10415016 631140 Expression of [L-selectin] on Th1 cells is *regulated* by . Positive_regulation SELL IL12B 10415016 631144 Given the key role played by IL-12 in the differentiation of naïve T cells into the Th1 subset , the observation that can also *regulate* [L-selectin] expression has implications for the migration of Th1 effector cells both through the lymphatic system and to sites of inflammation . Positive_regulation SELL IL12B 9647249 514975 NK activation by PMA , IL-2 , IL-15 , or TGF-beta down-regulated L-selectin on the CD56bright subset , while increased [L-selectin] levels were observed in both the CD56bright and CD56dim NK subsets in *response* to , IL-10 , or IFN-alpha . Positive_regulation SELL IL13 8392131 224753 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL13 8582548 341267 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL15 8392131 224754 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL15 8582548 341268 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL16 8392131 224755 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL16 8582548 341269 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL18 8392131 224756 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL18 8582548 341270 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL19 8392131 224757 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL19 8582548 341271 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL1A 1281830 205735 Production of activity by hypoxic ECs was associated with an increase in the level of mRNA for IL-1 alpha , and was *followed* by induction of [endothelial-leukocyte adhesion molecule-1] and enhanced expression of intercellular adhesion molecule-1 ( ICAM-1 ) during reoxygenation . Positive_regulation SELL IL1A 1370233 179277 Endothelial [leukocyte adhesion molecule 1] ( ELAM-1 ) is *induced* by PMA , , or TNFalpha , but its expression does not correlate with increased melanoma cell binding MoAb recognizing VCAM-1 inhibited TNFalpha induced increases in melanoma cell binding to HUVEC . Positive_regulation SELL IL1A 1680022 166503 The present in melanoma conditioned medium *induced* the expression of vascular cell adhesion molecule 1 , [endothelial-leukocyte adhesion molecule 1] , and ICAM-1 on human umbilical vein endothelial cells ( ECs ) in culture and increased the rate at which melanoma cells and ECs adhered to each other . Positive_regulation SELL IL1A 7528721 284146 *induced* expression of endothelial [leukocyte adhesion molecule-1] ( ELAM-1 ) is PKC dependent but insensitive to blocking of calmodulin . Positive_regulation SELL IL1A 7691964 231051 [Endothelial-leukocyte adhesion molecule-1] ( ELAM-1 ) expression *induced* at 6 and 24 h by TNF or , is restricted to the venular side of the capillary loop and to the venules proper . Positive_regulation SELL IL1B 10559516 566637 Enrichment of HAEC with the same doses of vitamin E suppressed *stimulated* expression of intercellular adhesion molecule-1 ( ICAM-1 ) , vascular cell adhesion molecule-1 ( VCAM-1 ) , and endothelial [leukocyte adhesion molecule-1] ( E-selectin ) . Positive_regulation SELL IL1B 10561528 566854 Surprisingly , stimulation with TNFalpha , IFNgamma and also *induced* the expression of [L-selectin] on fetal and diabetic Schwann cells , but not on normal adult cells . Positive_regulation SELL IL1B 7523851 272288 Transcription of the endothelial [leukocyte adhesion molecule 1] ( E-selectin or ELAM-1 ) gene is *induced* by the inflammatory cytokines and tumor necrosis factor alpha (TNF-alpha) . Positive_regulation SELL IL1B 7538427 301290 In parallel , DHA inhibited TNF-alpha stimulated monocytic U937 cell adhesion to HUVECs but did not affect TNF-alpha- or interferon gamma induced expression of intercellular adhesion molecule-1 and endothelial [leukocyte adhesion molecule-1] or VCAM-1 *induction* by . Positive_regulation SELL IL2 7678616 209947 Differential regulation of L-selectin can also be demonstrated in vitro by the activation of virgin T cells in the presence of specific cytokines -- induces L-selectin down-regulation , whereas IL-6 and particularly TGF-beta 1 *promote* [L-selectin] up-regulation . Positive_regulation SELL IL2 8392131 224758 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL2 8582548 341272 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL20 8392131 224759 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL20 8582548 341273 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL21 8392131 224760 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL21 8582548 341274 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL22 8392131 224743 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL22 8582548 341257 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL24 8392131 224740 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL24 8582548 341255 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL25 8392131 224742 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL25 8582548 341256 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL26 8392131 224747 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL26 8582548 341261 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL27 8392131 224748 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL27 8582548 341262 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL3 7685775 219813 stimulates proliferation and *triggers* [endothelial-leukocyte adhesion molecule 1] gene activation of human endothelial cells . Positive_regulation SELL IL3 8392131 224761 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL3 8582548 341275 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL31 8392131 224749 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL31 8582548 341263 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL32 8392131 224746 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL32 8582548 341260 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL33 8392131 224745 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL33 8582548 341259 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL34 8392131 224750 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL34 8582548 341264 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL37 8392131 224744 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL37 8582548 341258 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL4 1372287 182953 Natural killer cells , in contrast , did not exhibit CAE of LECAM-1 expression , and *had* no modulatory effect on [LECAM-1] expression by these cells . Positive_regulation SELL IL4 1375697 188214 ( 1 ng/ml ) and interferon gamma ( 100 U/ml ) also *increased* surface [LAM-1] levels on these cells to 218 +/- 119 % ( n = 8 , p less than 0.001 ) and 245 +/- 116 % ( n = 5 , p less than 0.001 ) of control levels respectively . Positive_regulation SELL IL4 20090929 2201613 We recently reported that *directs* mouse CD4 ( + ) CD25 ( - ) [CD62L] ( + ) T cells to commit to inflammatory IL-9 producing CD4 ( + ) T cells . Positive_regulation SELL IL4 8392131 224762 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL4 8582548 341276 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL5 8392131 224763 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL5 8582548 341277 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL6 1281215 205647 We have examined *induction* of [endothelial-leukocyte adhesion molecule 1] expression by human umbilical vein endothelial cells , secretion by U373 astrocytoma cells , and cytotoxicity of bovine endothelial cells . Positive_regulation SELL IL6 14738759 1202873 This [L-selectin] activation during heat responses was *dependent* on trans signaling via the soluble IL-6R . Positive_regulation SELL IL6 22977256 2688593 These results show that GdA interacts with [L-selectin] to *induce* production in monocytes/macrophages by activating the ERK signaling pathway . Positive_regulation SELL IL6 8392131 224764 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL6 8582548 341278 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL7 20831893 2346444 Cdc25A-driven proliferation regulates [CD62L] levels and lymphocyte movement in *response* to . Positive_regulation SELL IL7 8392131 224765 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL7 8582548 341279 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL8 8392131 224766 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL8 8582548 341280 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL IL8 9379058 465853 Stimulation through [L-selectin] *induced* membrane ruffling , whereas PAF or induced bipolar shape change . Positive_regulation SELL IL9 8392131 224767 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by tumor necrosis factor , , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL IL9 8582548 341281 Stimulation of confluent HUVECs , kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days , with 20 U/ml for 24 h ( ICAM-1 ) and 4 h ( endothelial leukocyte adhesion molecule 1 ) *resulted* in reduced ICAM-1 ( 84.8 +/- 27.0 % , p < 0.05 ) and endothelial [leukocyte adhesion molecule-1] ( 87.6 +/- 22.4 % , p < 0.05 ) expression vs control cells , while that of PECAM ( t : 24 h ) and vascular cell adhesion molecule-1 ( t : 16 h ) remained unchanged . Positive_regulation SELL ITGA4 7523519 272217 In contrast to neutrophil rolling , which is predominantly L-selectin dependent , eosinophil rolling was *mediated* by [L-selectin] , and also . Positive_regulation SELL ITGAM 10534700 562757 We sought to characterize neutrophil integrin and [L-selectin] *activation* associated with coronary artery bypass graft surgery and to determine whether neutrophil activation contributes to their sequestration on postbypass reperfusion . Positive_regulation SELL ITGAM 8831236 385724 EM down-regulated [L-selectin] expression , and *inhibited* up regulation of expression on peripheral blood neutrophils . Positive_regulation SELL ITGB1 7523519 272218 In contrast to neutrophil rolling , which is predominantly L-selectin dependent , eosinophil rolling was *mediated* by [L-selectin] , and also . Positive_regulation SELL ITGB2 10590058 572285 Together , these results indicate that LXA ( 4 ) stable analogs modulate expression of both [L-selectin] and CD11/CD18 on resting and immunostimulated leukocytes and *inhibit* neutrophil adhesion to HCAEC by attenuating expression . Positive_regulation SELL ITGB2 7532664 292147 In addition , cross linking of [L-selectin] *induced* an up-regulation of surface expression on neutrophils . Positive_regulation SELL KLF2 17548599 1752292 In this study , we show that in reporter gene assays directly *activates* the promoters of both [CD62L] and sphingosine-1-phosphate receptor 1 ( S1P1 ) , whose expression is critical for T cell egress from the thymus and homing to the lymph nodes . Positive_regulation SELL KLF2 21160050 2373426 was *required* for effective transcription of sphingosine-1-phosphate receptor-1 ( S1P(1) ) and [CD62L] in postactivation T cells . Positive_regulation SELL KRAS 11479463 842264 These findings suggest that AT1 receptor antagonism selectively modulates L-selectin expression on leukocytes and that endogenous stimulation of AT1 receptors by the *contributes* to the activation of leukocytes and decreased expression of [L-selectin] in CAD . Positive_regulation SELL KRAS 8986819 404095 Stimulation of the Ras pathway by L-selectin requires functional p56lck , since p56lck-deficient Jurkat cells ( JCaM1.6 ) do not show tyrosine phosphorylation , association of [L-selectin] with Grb2/Sos , and *activation* of upon L-selectin triggering . Positive_regulation SELL KRAS 9070897 419810 This actin polymerisation is mediated by a Ras and Rac2 regulated pathway , since inhibition of by transient transfection of transdominant inhibitory N17Ras or suppression of Rac2 protein expression by antisense oligonucleotides *prevents* [L-selectin] triggered actin polymerisation . Positive_regulation SELL LCK 18653462 1967073 Critical *role* of in [L-selectin] signaling induced by sulfatides engagement . Positive_regulation SELL LEO1 9163638 432105 Concentration dependent inhibition of the *induced* CD11b expression and [L-selectin] shedding for neutrophils and eosinophils was observed with rolipram , dibutyryl cyclic adenosine monophosphate ( cAMP ) , prostaglandin E2 ( PGE2 ) , and isoproterenol . Positive_regulation SELL LEO1 9379058 465852 Stimulation through [L-selectin] *induced* membrane ruffling , whereas or IL-8 induced bipolar shape change . Positive_regulation SELL MAPK1 10748078 690763 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Positive_regulation SELL MAPK1 16118270 1482208 In line with the results of former studies , we observed an upregulation of *activated* protein kinase-2 ( MAPKAP-K2 ) , [L-selectin] , and IL-1 receptor antagonist (IL-1ra) after exhaustive exercise . Positive_regulation SELL MAPK10 10748078 690764 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Positive_regulation SELL MAPK10 16118270 1482209 In line with the results of former studies , we observed an upregulation of *activated* protein kinase-2 ( MAPKAP-K2 ) , [L-selectin] , and IL-1 receptor antagonist (IL-1ra) after exhaustive exercise . Positive_regulation SELL MAPK11 10748078 690765 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Positive_regulation SELL MAPK11 16118270 1482210 In line with the results of former studies , we observed an upregulation of *activated* protein kinase-2 ( MAPKAP-K2 ) , [L-selectin] , and IL-1 receptor antagonist (IL-1ra) after exhaustive exercise . Positive_regulation SELL MAPK12 10748078 690766 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Positive_regulation SELL MAPK12 16118270 1482211 In line with the results of former studies , we observed an upregulation of *activated* protein kinase-2 ( MAPKAP-K2 ) , [L-selectin] , and IL-1 receptor antagonist (IL-1ra) after exhaustive exercise . Positive_regulation SELL MAPK13 10748078 690767 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Positive_regulation SELL MAPK13 16118270 1482212 In line with the results of former studies , we observed an upregulation of *activated* protein kinase-2 ( MAPKAP-K2 ) , [L-selectin] , and IL-1 receptor antagonist (IL-1ra) after exhaustive exercise . Positive_regulation SELL MAPK14 10748078 690768 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Positive_regulation SELL MAPK14 16118270 1482213 In line with the results of former studies , we observed an upregulation of *activated* protein kinase-2 ( MAPKAP-K2 ) , [L-selectin] , and IL-1 receptor antagonist (IL-1ra) after exhaustive exercise . Positive_regulation SELL MAPK15 10748078 690762 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Positive_regulation SELL MAPK15 16118270 1482207 In line with the results of former studies , we observed an upregulation of *activated* protein kinase-2 ( MAPKAP-K2 ) , [L-selectin] , and IL-1 receptor antagonist (IL-1ra) after exhaustive exercise . Positive_regulation SELL MAPK3 10748078 690769 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Positive_regulation SELL MAPK3 16118270 1482214 In line with the results of former studies , we observed an upregulation of *activated* protein kinase-2 ( MAPKAP-K2 ) , [L-selectin] , and IL-1 receptor antagonist (IL-1ra) after exhaustive exercise . Positive_regulation SELL MAPK4 10748078 690770 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Positive_regulation SELL MAPK4 16118270 1482215 In line with the results of former studies , we observed an upregulation of *activated* protein kinase-2 ( MAPKAP-K2 ) , [L-selectin] , and IL-1 receptor antagonist (IL-1ra) after exhaustive exercise . Positive_regulation SELL MAPK6 10748078 690771 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Positive_regulation SELL MAPK6 16118270 1482216 In line with the results of former studies , we observed an upregulation of *activated* protein kinase-2 ( MAPKAP-K2 ) , [L-selectin] , and IL-1 receptor antagonist (IL-1ra) after exhaustive exercise . Positive_regulation SELL MAPK7 10748078 690772 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Positive_regulation SELL MAPK7 16118270 1482217 In line with the results of former studies , we observed an upregulation of *activated* protein kinase-2 ( MAPKAP-K2 ) , [L-selectin] , and IL-1 receptor antagonist (IL-1ra) after exhaustive exercise . Positive_regulation SELL MAPK8 10748078 690773 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Positive_regulation SELL MAPK8 16118270 1482218 In line with the results of former studies , we observed an upregulation of *activated* protein kinase-2 ( MAPKAP-K2 ) , [L-selectin] , and IL-1 receptor antagonist (IL-1ra) after exhaustive exercise . Positive_regulation SELL MAPK9 10748078 690774 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Positive_regulation SELL MAPK9 16118270 1482219 In line with the results of former studies , we observed an upregulation of *activated* protein kinase-2 ( MAPKAP-K2 ) , [L-selectin] , and IL-1 receptor antagonist (IL-1ra) after exhaustive exercise . Positive_regulation SELL MMP1 8662605 365017 Recombinant human ( MMP1 ) reduced the number of L-selectin positive lymphocytes to a similar extent as phorbol ester activation , and stromelysin ( MMP3 ) *had* a partial effect on [L-selectin] expression . Positive_regulation SELL MMP9 9754865 535239 Ligation of [selectin L] and integrin CD11b/CD18 ( Mac-1 ) *induces* release of ( MMP-9 ) from human neutrophils . Positive_regulation SELL MTOR 18391955 1899316 The p110delta subunit of PI(3)K controlled CD62L proteolysis through mitogen activated protein kinases , whereas control of [CD62L] transcription by p110delta was *mediated* by through regulation of the transcription factor KLF2 . Positive_regulation SELL MYLIP 21149603 2373342 In fact , the induced overexpression of in otherwise normal ( C3H/HeOuj ) Treg cells *reduced* their [CD62L] expression , which mimics the altered Treg cell phenotype in MRL/lpr mice . Positive_regulation SELL NRAS 11479463 842265 These findings suggest that AT1 receptor antagonism selectively modulates L-selectin expression on leukocytes and that endogenous stimulation of AT1 receptors by the *contributes* to the activation of leukocytes and decreased expression of [L-selectin] in CAD . Positive_regulation SELL NRAS 8986819 404096 Stimulation of the Ras pathway by L-selectin requires functional p56lck , since p56lck-deficient Jurkat cells ( JCaM1.6 ) do not show tyrosine phosphorylation , association of [L-selectin] with Grb2/Sos , and *activation* of upon L-selectin triggering . Positive_regulation SELL NRAS 9070897 419811 This actin polymerisation is mediated by a Ras and Rac2 regulated pathway , since inhibition of by transient transfection of transdominant inhibitory N17Ras or suppression of Rac2 protein expression by antisense oligonucleotides *prevents* [L-selectin] triggered actin polymerisation . Positive_regulation SELL P2RX7 23319734 2738321 While investigating the mechanisms for this process , we revealed that pharmacological modulation of mitochondrial complex I or III , but not inhibition of NADPH oxidase , enhanced *dependent* [CD62L] downregulation by increasing ATP potency . Positive_regulation SELL PAF1 9163638 432103 Concentration dependent inhibition of the *induced* CD11b expression and [L-selectin] shedding for neutrophils and eosinophils was observed with rolipram , dibutyryl cyclic adenosine monophosphate ( cAMP ) , prostaglandin E2 ( PGE2 ) , and isoproterenol . Positive_regulation SELL PAF1 9379058 465850 Stimulation through [L-selectin] *induced* membrane ruffling , whereas or IL-8 induced bipolar shape change . Positive_regulation SELL PIK3CA 20564190 2285230 is *involved* in [L-selectin-] and PSGL-1 mediated neutrophil rolling on E-selectin via F-actin redistribution and assembly . Positive_regulation SELL PIK3CA 20564190 2285235 Western blot analysis demonstrated that activation , peaking within 5 min , was *induced* by ligation of [L-selectin] and PSGL-1 with E-selectin , and that Vav1 ( the pivotal downstream effector of PI3K signaling pathway involved in cytoskeleton regulation ) was recruited to the membrane and tyrosine phosphorylated , depending on PI3K . Positive_regulation SELL PIK3R1 20564190 2285231 is *involved* in [L-selectin-] and PSGL-1 mediated neutrophil rolling on E-selectin via F-actin redistribution and assembly . Positive_regulation SELL PIK3R1 20564190 2285236 Western blot analysis demonstrated that activation , peaking within 5 min , was *induced* by ligation of [L-selectin] and PSGL-1 with E-selectin , and that Vav1 ( the pivotal downstream effector of PI3K signaling pathway involved in cytoskeleton regulation ) was recruited to the membrane and tyrosine phosphorylated , depending on PI3K . Positive_regulation SELL PTPRC 9138016 427931 Loss of [L-selectin] *induced* by cross linking is followed by a rapid re-expression of the molecule upon incubation at 37 degrees C . Positive_regulation SELL PTX3 24387024 903804 Moreover , shedding of [L-selectin] *induced* by was attenuated by aminophylline , an adenosine receptor antagonist . Positive_regulation SELL PTX4 24387024 903803 Moreover , shedding of [L-selectin] *induced* by was attenuated by aminophylline , an adenosine receptor antagonist . Positive_regulation SELL SAA1 20201074 2265375 Recombinant potently *induced* cleavage of [L-selectin] from neutrophils and in whole blood samples . Positive_regulation SELL SDC1 18032547 1852110 Short-hairpin RNA mediated silencing demonstrates that on TECs indeed *mediates* [l-Selectin] binding . Positive_regulation SELL SEA 9716103 527834 Stimulation of PBM with also *resulted* in increased levels of soluble and [L-selectin] in the cell supernatants . Positive_regulation SELL SELP 10202042 605967 These modified proteins , sCR1sLex and sCR1 [ desLHR-A ] sLex , were assessed in the L-selectin- and *dependent* rat model of lung injury following systemic activation of complement by cobra venom factor and in the [L-selectin-] , P-selectin- , and E-selectin dependent model of lung injury following intrapulmonary deposition of IgG immune complexes . Positive_regulation SELL SELPLG 21596017 2441549 is *required* for mo-DC binding to both P- and [L-selectin] , but it is dispensable for E-selectin recognition . Positive_regulation SELL SLC33A1 11479463 842266 These findings suggest that AT1 receptor antagonism selectively modulates L-selectin expression on leukocytes and that endogenous stimulation of receptors by the RAS *contributes* to the activation of leukocytes and decreased expression of [L-selectin] in CAD . Positive_regulation SELL SMPD2 9716456 528308 The *activation* of the by [L-selectin] does not depend on tyrosine kinase activity and , therefore , represents an alternative and novel pathway to stimulate lymphocytes via L-selectin . Positive_regulation SELL SMURF1 21382345 2411712 Consequently , represses the transcriptional factor activity of KLF2 and *regulates* the expression its downstream genes such as [CD62L] and Wee1 . Positive_regulation SELL TGFB1 7678616 209946 Differential regulation of L-selectin can also be demonstrated in vitro by the activation of virgin T cells in the presence of specific cytokines -- IL-2 induces L-selectin down-regulation , whereas IL-6 and particularly *promote* [L-selectin] up-regulation . Positive_regulation SELL TLR1 23573259 2768059 *induced* CD11b and [L-selectin] response in patients with coronary artery disease . Positive_regulation SELL TLR10 23573259 2768067 *induced* CD11b and [L-selectin] response in patients with coronary artery disease . Positive_regulation SELL TLR2 23573259 2768060 *induced* CD11b and [L-selectin] response in patients with coronary artery disease . Positive_regulation SELL TLR3 23573259 2768061 *induced* CD11b and [L-selectin] response in patients with coronary artery disease . Positive_regulation SELL TLR4 23573259 2768062 *induced* CD11b and [L-selectin] response in patients with coronary artery disease . Positive_regulation SELL TLR5 23573259 2768063 *induced* CD11b and [L-selectin] response in patients with coronary artery disease . Positive_regulation SELL TLR6 23573259 2768068 *induced* CD11b and [L-selectin] response in patients with coronary artery disease . Positive_regulation SELL TLR7 23573259 2768064 *induced* CD11b and [L-selectin] response in patients with coronary artery disease . Positive_regulation SELL TLR8 23573259 2768065 *induced* CD11b and [L-selectin] response in patients with coronary artery disease . Positive_regulation SELL TLR9 23573259 2768066 *induced* CD11b and [L-selectin] response in patients with coronary artery disease . Positive_regulation SELL TNF 10480607 643526 These purified human islet MVEC ( HI-MVEC ) express von Willebrand factor , take up high levels of acetylated LDL , and upregulate endothelial cell [leukocyte adhesion molecule 1] in *response* to . Positive_regulation SELL TNF 11162639 782334 Since hyperhomocysteinemia appears to be an independent risk factor for the development of atherosclerosis , in this study we investigated the effect of homocysteine on basal and *induced* expression of intercellular adhesion molecule-1 ( ICAM-1 ) , vascular cell-adhesion molecule-1 ( VCAM-1 ) , and endothelial [leukocyte adhesion molecule-1] ( E-selectin ) on human umbilical-vein endothelial cells . Positive_regulation SELL TNF 1370233 179276 Endothelial [leukocyte adhesion molecule 1] ( ELAM-1 ) is *induced* by PMA , IL-1 alpha , or , but its expression does not correlate with increased melanoma cell binding MoAb recognizing VCAM-1 inhibited TNFalpha induced increases in melanoma cell binding to HUVEC . Positive_regulation SELL TNF 21237580 2397722 Stimulation with *resulted* in a significant decrease of [L-selectin] expression at 0 h ( 25.6±2.7 ng/ml ; p < 0.05 ) and 24 h ( 18.3±2.5 ng/ml ; p < 0.05 ) , but not at 48 h ( 39.8±4.2 ng/ml ) . Positive_regulation SELL TNF 21237580 2397723 The study results indicate that the primary pro-inflammatory cytokine *regulates* the [L-selectin] surface expression on PMN after surgical trauma . Positive_regulation SELL TNF 7684420 217583 Elevated cyclic AMP inhibits endothelial cell synthesis and expression of *induced* endothelial [leukocyte adhesion molecule-1] , and vascular cell adhesion molecule-1 , but not intercellular adhesion molecule-1 . Positive_regulation SELL TNF 7691964 231050 [Endothelial-leukocyte adhesion molecule-1] ( ELAM-1 ) expression *induced* at 6 and 24 h by or IL-1 , is restricted to the venular side of the capillary loop and to the venules proper . Positive_regulation SELL TNF 8392131 224741 Surface protein expression of vascular cell adhesion molecule-1 , endothelial [leukocyte adhesion molecule-1] , or intercellular adhesion molecule-1 , which is *induced* by , interleukin-1 , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation SELL TNF 8392131 224824 Additionally , activators of the stimulatory or inhibitory guanine nucleotide dependent binding proteins did not affect *induced* surface expression of endothelial [leukocyte adhesion molecule-1] or vascular cell adhesion molecule-1 . Positive_regulation SELL TNF 9008610 410849 Pretreatment of neutrophils with either NSAID prevented the changes in [L-selectin] and CD11b expression *induced* by , GM-CSF , and FMLP , but not those induced by PMA or A23187 . Positive_regulation SELL TNF 9052593 417169 We found that 17 beta-estradiol augmented the *induced* expression of endothelial [leukocyte adhesion molecule-1] , intercellular adhesion molecule-1 , and vascular cell adhesion molecule-1 by 107 , 9 , and 39 % , respectively . Positive_regulation SELL TNF 9500713 490954 On HLVEC , PGE1 down-regulated *induced* expression of endothelial cell [leukocyte adhesion molecule 1] and vascular adhesion molecule 1 , but not intercellular adhesion molecule 1 . Positive_regulation SELL UTP15 8600168 351813 , ADP , and adenosine ( all at 500 microM ) *had* no effect on [L-selectin] expression . Positive_regulation SELL UTP18 8600168 351811 , ADP , and adenosine ( all at 500 microM ) *had* no effect on [L-selectin] expression . Positive_regulation SELL UTP20 8600168 351809 , ADP , and adenosine ( all at 500 microM ) *had* no effect on [L-selectin] expression . Positive_regulation SELL UTP23 8600168 351814 , ADP , and adenosine ( all at 500 microM ) *had* no effect on [L-selectin] expression . Positive_regulation SELL UTP3 8600168 351812 , ADP , and adenosine ( all at 500 microM ) *had* no effect on [L-selectin] expression . Positive_regulation SELL UTP6 8600168 351810 , ADP , and adenosine ( all at 500 microM ) *had* no effect on [L-selectin] expression . Positive_regulation SELL VCAM1 7690868 228657 These results show for the first time ( a ) endothelial induction in various glomerulonephritides and ( b ) [endothelial-leukocyte adhesion molecule-1] *induction* in the kidney . Positive_regulation SELL WDR61 9163638 432104 Concentration dependent inhibition of the *induced* CD11b expression and [L-selectin] shedding for neutrophils and eosinophils was observed with rolipram , dibutyryl cyclic adenosine monophosphate ( cAMP ) , prostaglandin E2 ( PGE2 ) , and isoproterenol . Positive_regulation SELL WDR61 9379058 465851 Stimulation through [L-selectin] *induced* membrane ruffling , whereas or IL-8 induced bipolar shape change . Positive_regulation SELP ANGPT1 17984290 1859851 *mediated* endothelial [P-selectin] translocation : cell signaling mechanisms . Positive_regulation SELP ANGPT1 17984290 1859857 In addition , we demonstrate for the first time that *mediated* endothelial [P-selectin] translocation is calcium dependent and regulated through phospholipase C-gamma activation . Positive_regulation SELP CAPN8 15985533 1428581 We observed a smoke extract induced , *dependent* degradation of the intracellular form of platelet-endothelial cell adhesion molecule 1/CD31 , as well as a release of [P-selectin/CD62P] , IL-6 , and IL-8 from endothelial cells into the supernatant . Positive_regulation SELP F2R 16520742 1549378 3 [P-selectin] expression *induced* by ADP or was strongly inhibited by YM-254890 , with IC ( 50 ) values of 0.51+/-0.02 and 0.16+/-0.08 microM , respectively . Positive_regulation SELP F2R 23340049 2769785 The vasodilator stimulated phosphoprotein ( VASP ) phosphorylation assay , multiple electrode aggregometry (MEA) with adenosine diphosphate ( ADP ) , and surface expressions of [P-selectin] and activated glycoprotein (GP) IIb/IIIa in *response* to ADP and activating peptide ( TRAP ) -6 were assessed in 71 obese and 245 nonobese patients . Positive_regulation SELP F2R 24845383 2940493 We treated gel filtered human platelets with cGMP and cAMP analogues , and used flow cytometric assays to detect low dose thrombin induced formation of small platelet aggregates , single platelet disappearance (SPD) , platelet derived microparticles (PMP) and *induced* [P-selectin] expression . Positive_regulation SELP FUT4 15579466 1368535 Here we have examined the *role* of human and -VII in conferring L-selectin , [P-selectin] , and E-selectin binding activities to PSGL-1 . Positive_regulation SELP FUT4 7505206 237572 Significant binding of transfected COS cells to [P-selectin] *requires* coexpression of both the protein ligand and a . Positive_regulation SELP HES2 16247329 1471606 After stimulation with IL-1 ( 10 U/mL ) , *had* no effect on the expression of [P-selectin] , E-selectin , ICAM-1 , or VCAM-1 . Positive_regulation SELP HES2 20028511 2176779 At 40 % but not at 10 % haemodilution rate , 200/0.5 also increased platelet fibrinogen binding and both HES solutions *increased* expression of [CD62P] , the main receptor for platelet-leukocyte adhesion . Positive_regulation SELP IL1B 8691152 372737 Tumor necrosis factor alpha , , lipopolysaccharide , or IL-3 did not increase P-selectin mRNA in HUVEC , and did not *augment* the IL-4 induced increase in [P-selectin] transcripts . Positive_regulation SELP IL1B 8977250 403204 Constitutive P-selectin expression is largely absent in cultured murine brain microvascular EC ( BMEC ) monolayers , but and tumor necrosis factor-alpha stimulation for 4 hours *leads* to dramatic [P-selectin] upregulation . Positive_regulation SELP PECAM1 19714308 2127451 Significant radiation induced increase of ICAM-1 ( intercellular adhesion molecule-1 ) , VCAM-1 ( vascular cell adhesion molecule-1 ) , JAM-1 ( junctional adhesion molecule-1 ) , beta1-integrin , beta2-integrin , E-cadherin , and [P-selectin] gene expression could be *detected* in vivo , while ( platelet-endothelial cell adhesion molecule-1 ) gene expression remained unchanged . Positive_regulation SELP PLAT 9489975 489321 The presence of urokinase and *increased* platelet surface [P-selectin] expression in a concentration dependent manner . Positive_regulation SELP SELL 11404363 842973 Following the recent description of the affinity and kinetics of the selectin-ligand pairs *dependent* cell adhesion molecule-1 and [P-selectin-P-selectin] glycoprotein ligand-1 , this is the first determination of the parameters of E-selectin binding to one of its naturally occurring ligands . Positive_regulation SELP SELL 18334871 1881496 No arteriovenous gradient was observed in [P-selectin] expression , but expression ( arbitrary units ) , *increased* in the mesenteric vasculature of the UC patients [ arterial 839 ( 503-995 ) , venous 879 ( 477-1035 ) ; Positive_regulation SELP SELL 8909556 394518 is not *involved* in direct binding to either E- or [P-selectin] and is not a major counterreceptor of endothelial selectins . Positive_regulation SELP TLR7 24755410 2950144 The mechanism includes *mediated* platelet granule release , translocation of [P-selectin] to the cell surface , and a consequent increase in platelet-neutrophil adhesion . Positive_regulation SELP TNF 10749570 681179 Alveolar increased [ Ca ( 2+ ) ] ( i ) and activated cPLA(2) in alveolar epithelial cells , and *increased* both endothelial [ Ca ( 2+ ) ] ( i ) and [P-selectin] expression in adjoining perialveolar capillaries . Positive_regulation SELP TNF 10961383 726441 Taken together , our data demonstrate that [P-selectin] function plays an important role in *induced* inflammatory cell recruitment by mediating leukocyte rolling as a precondition for cytokine provoked firm adhesion and transmigration in vivo . Positive_regulation SELP TNF 11110771 757362 In conclusion , induced neutrophil recruitment into the brain *requires* both endothelial E-selectin and [P-selectin] as well as platelets , but platelet P-selectin was not a major contributor to this process . Positive_regulation SELP TNF 11124826 769019 Preconditioning protects against systemic disorders associated with hepatic ischemia-reperfusion through blockade of *induced* [P-selectin] up-regulation in the rat . Positive_regulation SELP TNF 11355655 815435 Control skin displayed no expression of E- and P-selectin , whereas *induced* the expression of [P-selectin] and E-selectin on dermal vessels that was highest at 12 hours and 3 hours , respectively ( P < 0.05 ) . Positive_regulation SELP TNF 1378846 192684 We show that synthesis of mouse [P-selectin] , like that of E-selectin , is transiently *induced* by in several endothelioma cell lines derived from different mouse tissues . Positive_regulation SELP TNF 14617755 1168539 Furthermore , hyperosmolar infusion blocked *induced* [P-selectin] expression in an actin dependent manner . Positive_regulation SELP TNF 16641609 1553062 Surface expression of ICAM-1 , VCAM-1 , and [E-/P-selectin] on MVEC was *up-regulated* by but unaffected by hypoxia/reoxygenation in the absence of TNF-alpha . Positive_regulation SELP TNF 16641609 1553065 ICAM-1 expression was further increased by a combination of TNF-alpha and hypoxia/reoxygenation , whereas *induced* [E-/P-selectin] expression was strongly reversed by hypoxia/reoxygenation . Positive_regulation SELP TNF 19231583 2040012 Inhibition of p38 MAPK decreased dose-dependently the mast cell generated TNF-alpha production as well as *induced* expression of [P-selectin] and neutrophil adhesion on endothelial cells . Positive_regulation SELP TNF 19631345 2286956 *induced* leukocyte adhesion as well as [P-selectin] expression in endothelial cells and LFA-1 function were inhibited by simvastatin in vitro . Positive_regulation SELP TNF 21149548 2358052 However , *increased* murine [P-selectin] in venules , slowing rolling and increasing adhesion , whereas it decreased human P-selectin , accelerating rolling and decreasing adhesion . Positive_regulation SELP TNF 21981016 2547158 We investigated how expression of ICAM-1 , VCAM-1 , MAdCAM-1 , PECAM-1 , E- and [P-selectin] in *response* to , IL-1ß and IFN-? was altered by aglycemia ( A ) , hypoxia ( H ) or combined oxygen glucose deprivation ( OGD ) . Positive_regulation SELP TNF 22266330 2575496 To assess in vivo attachment efficiency to endothelial counterligands that vary in their distance from the endothelial cell surface , contrast enhanced ultrasound ( CEU ) molecular imaging of *induced* [P-selectin] ( long distance ) or intercellular adhesion molecule-2 ( short distance ) was performed with each agent in murine hind limbs . Positive_regulation SELP TNF 22998024 2694262 These findings suggest that iNOS derived NO increases TNF-a levels in the middle and distal colon and increased levels *induce* expression of [P-selectin] and ICAM-1 , thereby promoting the infiltration of activated neutrophils , which leads to damage to colonic tissue . Positive_regulation SELP TNF 7523771 243729 Inflammatory mediators likely to occur under those conditions , e.g. , histamine , thrombin , oxygen derived free radicals (ODFR) , interleukin (IL)-1 , , and activated complement factors , *induce* in a distinct time course the ( transient ) expression of the leukocyte adhesion molecules [P-selectin] , E-selectin , intercellular adhesion molecule (ICAM)-1 , and vascular cell adhesion molecule (VCAM)-1 on the endothelium . Positive_regulation SELP TNF 7683689 216557 We have recently shown that *stimulates* the synthesis of [P-selectin] in mouse endothelioma cells ( A. Weller , S. Isenmann , D. Vestweber . Positive_regulation SELP TNF 7683689 216558 Thus , in addition to the three known TNF-inducible CAMs , ICAM-1 , VCAM-1 , and E-selectin , also [P-selectin] and a fifth , as yet molecularly undefined cell adhesion mechanism , are *inducible* at the cell surface of mouse endothelioma cells . Positive_regulation SELP TNF 8977250 403203 Constitutive P-selectin expression is largely absent in cultured murine brain microvascular EC ( BMEC ) monolayers , but interleukin-1beta and stimulation for 4 hours *leads* to dramatic [P-selectin] upregulation . Positive_regulation SELP TNF 9366433 463253 A dual radiolabeled mAb technique was used to quantify constitutive and *induced* expression of ICAM-1 , VCAM-1 , E-selectin , and [P-selectin] in different vascular beds ( lung , heart , stomach , mesentery , small intestine , large intestine , and muscle ) in wild-type and SCID mice . Positive_regulation SELP TNF 9545354 498606 The presence of these elements in the murine , but not the human , P-selectin gene may explain in part why or LPS *stimulates* transcription of [P-selectin] in a species-specific manner . Positive_regulation SELPLG ITGB2 17332469 1747963 T cell associated but not CD62L , ICAM-1 , or [PSGL-1] is *required* for the induction of chronic colitis . Positive_regulation SELPLG ITGB2 22431571 2588324 Here , we *induce* differential activation in neutrophils through engagement of the selectin ligand [P-selectin glycoprotein ligand-1] or the chemokine receptor CXCR2 . Positive_regulation SELPLG SELL 11404363 842974 Following the recent description of the affinity and kinetics of the selectin-ligand pairs *dependent* cell adhesion molecule-1 and [P-selectin-P-selectin glycoprotein ligand-1] , this is the first determination of the parameters of E-selectin binding to one of its naturally occurring ligands . Positive_regulation SEMA3A TLR7 21098092 2357786 engagement can *induce* [Sema3A] expression , thus completing an autocrine loop . Positive_regulation SEMA3C ADAMTS1 19915008 2189954 The cleavage of [semaphorin 3C] *induced* by promotes cell migration . Positive_regulation SEMA3C ADAMTS1 19915008 2189956 Here , we show that the cleavage of [semaphorin 3C] *induced* by promotes the migration of breast cancer cells , indicating that the co-expression of these molecules in tumors may contribute to the metastatic program . Positive_regulation SENP1 TNF 18219322 1876736 *induces* the release of [SENP1] from thioredoxin as well as nuclear translocation of SENP1 . Positive_regulation SENP1 TNF 18219322 1876737 TNF induced SENP1 nuclear translocation is specifically blocked by antioxidants such as N-acetyl-cysteine , suggesting that *induced* translocation of [SENP1] is ROS dependent . Positive_regulation SEPP1 EPHB2 21893096 2496539 Furthermore , the *activation* of phosphorylation and the NFAT promoter by [SEP] promoted the transcription and expression of downstream gene IL-2 . Positive_regulation SEPP1 FOXO1 17986386 1845995 In conclusion , the selenoprotein P promoter is a target of the Akt/FoxO signal transduction cascade and [SeP] expression is *regulated* at the level of transcription by the forkhead box protein in human and rat hepatoma cells . Positive_regulation SEPP1 FOXO1 18972406 1995088 Recently , we reported *stimulation* of [SeP] promoter activity by the forkhead box transcription factor in hepatoma cells and its attenuation by insulin . Positive_regulation SEPT5 CAPN8 22665935 2626089 The *dependent* cleavage of [septin-5] disturbed its association with syntaxin-4 and promoted the secretion of a-granule contents , including TGF-ß and CCL5 . Positive_regulation SERF1A TNF 20837479 2352871 Indeed , *stimulated* endothelial expression of HS ( [NS4F5] ) , which contributed to leukocyte adhesion . Positive_regulation SERINC3 TNF 16715133 1638314 Taken together , these data suggest that *upregulation* of [TMS1/ASC] by and subsequent activation of caspase-8 could function to amplify the apoptotic signal induced by death receptors in some cell types , including breast epithelial cells . Positive_regulation SERPINA1 IL1B 9445306 483339 [Alpha 1-antitrypsin] and protease complexation is *induced* by lipopolysaccharide , , and tumor necrosis factor-alpha in monocytes . Positive_regulation SERPINA1 TNF 17937578 1825583 However , after Z SDF transfection , M monocytes failed to increase [alpha (1)-AT] secretion in *response* to stimulation . Positive_regulation SERPINA1 TNF 21723846 2466030 [SerpinA1] production by SCC cells was dependent on p38 mitogen activated protein kinase activity and was *up-regulated* by epidermal growth factor , , interferon-? , and IL-1ß . Positive_regulation SERPINA1 TNF 9012541 405323 [Elastase-alpha 1-AT] was *detected* early , with most release occurring between 15-30 min whereas was detected later , between 120-180 min. Dexamethasone , prostacyclin and pentoxifylline caused a dose dependent inhibition of TNF alpha release but had no effect on elastase release . Positive_regulation SERPINA1 TNF 9445306 483338 [Alpha 1-antitrypsin] and protease complexation is *induced* by lipopolysaccharide , interleukin-1beta , and in monocytes . Positive_regulation SERPINA3 IL1B 15688088 1416490 Ibuprofen suppresses *induction* of pro-amyloidogenic [alpha1-antichymotrypsin] to ameliorate beta-amyloid ( Abeta ) pathology in Alzheimer 's models . Positive_regulation SERPINA3 IL1B 8747137 343522 and TNF alpha , but not IL-6 , *induce* [alpha 1-antichymotrypsin] expression in the human astrocytoma cell line U373 MG . Positive_regulation SERPINA3 IL6R 9461605 484864 Oncostatin M and the interleukin-6 and soluble complex *regulate* [alpha1-antichymotrypsin] expression in human cortical astrocytes . Positive_regulation SERPINA3 TNF 19800391 2159492 [Alpha1-antichymotrypsin] *induces* production and NF-kappaB activation in the murine N9 microglial cell line . Positive_regulation SERPINA3 TNF 2429991 64343 In picomolar concentrations , *mediated* reversible , dose- and time dependent increases in biosynthesis of complement proteins factor B and C3 , [alpha 1 antichymotrypsin] , and decreases in biosynthesis of albumin and transferrin in human hepatoma cell lines ( Hep G2 , Hep 3B ) . Positive_regulation SERPINA3 TNF 8747137 343521 IL-1 beta and , but not IL-6 , *induce* [alpha 1-antichymotrypsin] expression in the human astrocytoma cell line U373 MG . Positive_regulation SERPINA3 TNF 8863511 388841 Interleukin-1 beta and *induce* expression of [alpha 1-antichymotrypsin] in human astrocytoma cells by activation of nuclear factor-kappa B . Positive_regulation SERPINA4 FOXO1 20081110 2212549 Pivotal *role* of JNK dependent activation in downregulation of [kallistatin] expression by oxidative stress . Positive_regulation SERPINA5 CD8A 19818719 2164514 The [pCI/S] but not pCI/S ( L39V ) DNA vaccination *induced* L ( d ) /S ( 28-39 ) -specific T cell responses . Positive_regulation SERPINA5 CISH 10805286 691961 *required* for expression of human [protein C inhibitor] gene in HepG2 cells and its androgen dependent expression in rat reproductive organs . Positive_regulation SERPINA5 SERPINE1 16882293 1594578 [PAI III] ( 536 ) was *detected* only in UPEC ( 2 % ) , while ( J96 ) was not detected in any isolate . Positive_regulation SERPINA6 IL1B 9360537 462333 dose-dependently *stimulated* [CBG] secretion ( 156 +/- 10 % of control values ) with no significant effect on CBG mRNA levels . Positive_regulation SERPINB2 IL1B 15368874 1297127 Modulating effect of serum on the *stimulation* of [plasminogen activator inhibitor 2] production in human gingival fibroblasts by lipopolysaccharide and . Positive_regulation SERPINB2 IL1B 1536945 180489 decreased PAI-1 levels by 50 % and *stimulated* [PAI-2] levels sixfold . Positive_regulation SERPINB2 PLAT 10215917 608238 Up-regulation of expression by BDNF is *followed* by the induction of [plasminogen activator inhibitor 2] ( PAI-2 ) , an inhibitor of tPA . Positive_regulation SERPINB2 TGM2 10816585 714723 In this study , we identified lysine residues in the fibrinogen Aalpha chain that serve as substrates during *mediated* cross linking of [plasminogen activator inhibitor 2] ( PAI-2 ) . Positive_regulation SERPINB2 TNF 10469140 641013 Here we have examined whether [PAI-2] gene transcription in *response* to may be mediated through a regulatory pathway involving the transcription factor , NF-kappaB . Positive_regulation SERPINB2 TNF 1389210 198714 [PAI-2] release is *induced* by and TGF-beta . Positive_regulation SERPINB2 TNF 14707582 1196573 In all EC , stimulation with and lipopolysaccharide *increased* the expression of PAI-1 , [PAI-2] , and u-PA and decreased t-PA expression . Positive_regulation SERPINB2 TNF 2324095 132178 In addition , *induction* of [PAI-2] synthesis by was blocked by two PKC inhibitors , staurosporine and 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperazine dihydrochloride . Positive_regulation SERPINB2 TNF 2324095 132179 In contrast to the positive regulation by PKC in promoting *induced* [PAI-2] synthesis cAMP inhibited this response . Positive_regulation SERPINB2 TNF 2324095 132180 Pretreatment of cells with agents that raise intracellular cAMP levels completely abolished *induced* [PAI-2] synthesis . Positive_regulation SERPINB2 TNF 2324095 132181 [PAI-2] mRNA accumulation in *response* to was inhibited , but not completely abolished , by cAMP elevating agents , suggesting that cAMP also exerted its inhibitory effect at the translation level . Positive_regulation SERPINB2 TNF 2555368 122019 By 3-5 h , PMA or *induced* both tissue factor and [PAI-2] to approximately 150-420 mRNA molecules/cell and both mRNAs declined to basal levels within several hours ; Positive_regulation SERPINB2 TNF 7778058 309337 Stimulation with LPS or *increased* the expression of PAI-1 , u-PA and [PAI-2] in HUVEC and HSVEC , while the t-PA response differed between the two cell types . Positive_regulation SERPINB2 TNF 7778058 309338 In contrast , *induced* expression of [PAI-2] was synergistically increased by addition of IFN-gamma . Positive_regulation SERPINB2 TNF 8456426 215462 IL-1 alpha and *increased* the synthesis of [PAI-2] and PAI-1 by EC in a dose dependent manner . Positive_regulation SERPINB2 TNF 8824249 384950 and PMA co-treatment of transfected cells *increases* [beta-globin-PAI-2] chimeric mRNA expression 3-4-fold , indicating that the inherently unstable 3'-UTR of PAI-2 mRNA can become stabilized in response to TNF and PMA . Positive_regulation SERPINB2 TNF 8824249 384951 Our results indicate that *induction* of [PAI-2] gene expression by and PMA involves both direct transcription as well as mRNA stabilization , the latter involving an AU-rich nonameric motif in the 3'-UTR . Positive_regulation SERPINB2 TNF 8898893 393155 Removal of the proximal repressor by deletion to position -219 , or by internal deletion from the -1100 PAI-2 CAT construct , resulted in a selective increase in TNF responsiveness , suggesting that *induction* of [PAI-2] gene transcription by is associated with derepression . Positive_regulation SERPINB2 TNF 8898893 393158 Our findings suggest that *mediated* induction of [PAI-2] gene expression involves derepression and is associated with cis acting and trans acting factors located within and adjacent to the proximal repressor region . Positive_regulation SERPINB3 CCND1 19414362 2075389 Also , after EGFR stimulation , and CHK2 levels *increased* most prominently in [UT-SCC-26A] , whereas CHK2 levels dropped again at higher EGF concentrations . Positive_regulation SERPINB3 CLDN10 24114540 2863674 Downregulation of by siRNA *resulted* in the decrease of [SCC] and PD , but not TER , in B4G12 cells . Positive_regulation SERPINB3 EDN2 1725345 176808 The *stimulation* of [SCC] by was likely to be due to an increase to anion secretion as removal of Cl from the incubation medium markedly reduced the SCC response to endothelin . Positive_regulation SERPINB3 EDN2 1725345 176814 Diphenylamine-2-carboxylate ( DPC , 0.1 mM ) , a Cl-channel blocker , added to the apical side also inhibited the *induced* rise in [SCC] . Positive_regulation SERPINB3 EDN2 1725345 176817 The *stimulation* of [SCC] by was accompanied by a rise in the intracellular cyclic AMP content in epididymal monolayers . Positive_regulation SERPINB3 EDN2 2482100 122766 3. The *stimulation* of [SCC] by was accompanied by a rise in the intracellular adenosine 3 ' : 5'-cyclic monophosphate ( cyclic AMP ) content in epididymal monolayers . Positive_regulation SERPINB3 IL1B 21912958 2524870 In the present study , we examined the potential *role* and prognostic value of in esophageal [squamous cell carcinoma (SCC)] . Positive_regulation SERPINB3 MMP28 18284387 1885347 The *role* of in RDEB associated [SCC] is not known . Positive_regulation SERPINB3 MMP7 18284387 1885362 The *role* of in RDEB associated [SCC] is not known . Positive_regulation SERPINB3 TNF 11781145 900164 In the process of searching for agents to inhibit MMP-9 in cancer , immunosuppressive factors , dexamethasone ( DEX ) and interleukin-4 (IL-4) were found to inhibit protein production as well as gene expression of MMP-9 in *stimulated* [SCC] cells . Positive_regulation SERPINB3 TNF 9679762 520882 Moreover , ALLN could block the activation and nuclear translocation of a transcription activating factor , NF-kappaB , which is known to regulate MMP-9 expression in *stimulated* [SCC] cells . Positive_regulation SERPINB5 F2R 21147226 2396187 In turn , the , PAR-1 , *regulates* the expression of the gap junction protein Connexin-43 and the tumor suppressor gene [Maspin] . Positive_regulation SERPINB5 GPNMB 22290289 2636613 overexpression *induced* the gene expressions of N-myc downstream regulated gene 1 ( Ndrg1 ) and [maspin] in PC-3 cells . Positive_regulation SERPINB5 TP63 15466179 1305390 Instead , [maspin] expression was strictly *dependent* on the presence of in lung cancer tissues ( P < 0.001 ) and in the tested cell lines . Positive_regulation SERPINB5 TP63 15466179 1305391 Transient expression of *transactivated* the [maspin] promoter with remarkable fold changes in cells expressing the TAp63 , suggesting that TAp63 might be a novel stimulator of the maspin promoter in lung cancer . Positive_regulation SERPINB5 TP63 15578720 1368511 To assess a potential function of *dependent* [maspin] upregulation in tumors we followed expression of p53 , p63 and maspin by immunohistochemistry in hepatocellular carcinomas . Positive_regulation SERPINB9 TNF 15128837 1245289 IFN-gamma and also *induced* 4- to 10-fold higher levels of [PI-9] mRNA expression in Huh-7 cells , whereas levels of mRNA encoding a related serine proteinase inhibitor , proteinase inhibitor 8 , were unaffected by culture of Huh-7 cells with IFN-alpha , IFN-gamma , or TNF-alpha . Positive_regulation SERPIND1 PLAT 10632469 576573 In an in vitro test , bovine intestine dermatan sulfate exhibited stronger effects on stimulation of [heparin cofactor II] and *activation* of Glu-plasminogen by . Positive_regulation SERPINE1 AGR2 16413628 1561076 has an adipogenic effect and *increases* [PAI-1] expression . Positive_regulation SERPINE1 CLU 22052058 2534069 In cultured rat tubular epithelium-like cells , adenovirus mediated overexpression of *inhibited* the expression of TGF-ß stimulated [PAI-1] , type I collagen , and fibronectin . Positive_regulation SERPINE1 CTGF 15950619 1421503 Expression of the TGFbeta-responsive genes [PAI-1] and Col III over 48 h was maximally *stimulated* by compared to TGFbeta alone , while CTGF alone had no significant effect . Positive_regulation SERPINE1 CTGF 23872073 2835313 Genetic deficiency of either EGFR or p53 or functional blockade with AG1478 or Pifithrin-a , respectively , effectively inhibited [PAI-1and] *induction* and morphological transformation of renal fibroblasts as did SMAD3 knockdown or pretreatment with the SMAD3 inhibitor SIS3 . Positive_regulation SERPINE1 CTGF 7593235 334632 NAK-1 , [PAI-1] , and HSP-70 were induced or stimulated only in cells at the wound edge , u-PA was stimulated in cells away from the wound , and was *induced* in each of these populations suggesting that cell-to-cell communication may regulate gene expression after wounding . Positive_regulation SERPINE1 EPHB2 12595493 1061603 PDGF-BB induced expression of TGF-beta1 was mediated by JNK and p38 , MCP-1 expression was through ERK , JNK , and p38 , whereas [PAI-1] expression was *due* to only . Positive_regulation SERPINE1 EPHB2 14631113 1170486 Based on these results , we suggest that both MEK and are *involved* in the induction of [PAI-1] gene expression during cell adhesion . Positive_regulation SERPINE1 EPHB2 17172275 1717233 The induction of [PAI-1] by TNF-alpha and insulin is *mediated* , in part , by and p38 MAPK . Positive_regulation SERPINE1 EPHB2 17396111 1760660 An kinase inhibitor significantly *reduced* the renin induced ERK1/2 phosphorylation and the subsequent increase in transforming growth factor-beta1 ( TGF-beta1 ) and [plasminogen activator inhibitor-1] mRNA expression . Positive_regulation SERPINE1 EPHB2 17474984 1738361 Inhibition of downstream activation decreased TGF-beta *induced* CTGF and [PAI-1] expression to a basal level . Positive_regulation SERPINE1 EPHB2 17474984 1738363 The data provide evidence that beside the TGF-beta-Smad 3 pathway CTGF and [PAI-1] expression is additionally *dependent* on activity in hepatocytes giving new insights into regulation of the profibrogenic proteins . Positive_regulation SERPINE1 EPHB2 18061125 1846789 Ox-LDL stimulation of [plasminogen activator inhibitor-1] ( PAI-1 ) expression via transforming growth factor-beta ( TGF-beta ) /Smad signaling in mesangial cells *required* activation of extracellular signal regulated kinase ( ) . Positive_regulation SERPINE1 EPHB2 19249354 2050998 Differential *requirement* for and SMAD signaling in [PAI-1] and CTGF expression in response to microtubule disruption . Positive_regulation SERPINE1 EPHB2 20020854 2009322 P38 kinase inhibitor SB203580 ( 20 muM ) and inhibitor PD98059 ( 50 muM ) *suppressed* silica induced [PAI-1] expression by 35 % and 51 % , respectively . Positive_regulation SERPINE1 EPHB2 21621740 2436381 The kinase inhibitor , U0126 , partially *prevented* the induction of [PAI-1] by AGEs . Positive_regulation SERPINE1 EPHB2 22610405 2614611 , which interacts with RHAMM , was *necessary* for induction of [PAI-1] by HA . Positive_regulation SERPINE1 F2R 9379363 465873 The effects of different flavonoids isolated from the roots of Scutellaria baicalensis Georgi on the production of tissue-type plasminogen activator (t-PA) and [plasminogen activator inhibitor-1] ( PAI-1 ) *induced* by thrombin and agonist peptide , Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe , have been examined in cultured human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation SERPINE1 F2R 9379363 465876 Thrombin and agonist peptide *induced* production of both t-PA and [PAI-1] and the elevation of intracellular free calcium concentration ( [ Ca2+ ] i ) . Positive_regulation SERPINE1 F2R 9379363 465877 Baicalein isolated from Scutellariae Radix dose-dependently inhibited [PAI-1] production *induced* by thrombin and agonist peptide ; Positive_regulation SERPINE1 F2R 9579636 503393 The present study demonstrates that the , pertussis toxin-sensitive G protein , genistein-sensitive tyrosine kinase , phospholipase C , and protein kinase C may be *involved* in thrombin induced [PAI-1] production in cultured baboon aortic SMC . Positive_regulation SERPINE1 GPR115 15808835 1391541 Role of c-Jun NH2-terminal kinase in agonist *induced* cardiac [plasminogen activator inhibitor-1] expression . Positive_regulation SERPINE1 GPR115 15808835 1391637 In conclusion , agonist induced [PAI-1] expression is partially *mediated* through JNK activation . Positive_regulation SERPINE1 GPR132 15808835 1391530 Role of c-Jun NH2-terminal kinase in agonist *induced* cardiac [plasminogen activator inhibitor-1] expression . Positive_regulation SERPINE1 GPR132 15808835 1391626 In conclusion , agonist induced [PAI-1] expression is partially *mediated* through JNK activation . Positive_regulation SERPINE1 GPR87 15808835 1391610 Role of c-Jun NH2-terminal kinase in agonist *induced* cardiac [plasminogen activator inhibitor-1] expression . Positive_regulation SERPINE1 GPR87 15808835 1391706 In conclusion , agonist induced [PAI-1] expression is partially *mediated* through JNK activation . Positive_regulation SERPINE1 IL1B 10102472 602254 The *activation* of [plasminogen activator inhibitor-1] expression by is attenuated by estrogen in hepatoblastoma HepG2 cells expressing estrogen receptor alpha . Positive_regulation SERPINE1 IL1B 10516146 652273 These results suggest that is a critical *inducer* of hepatic [PAI-1] gene expression during the acute phase response to local tissue injury . Positive_regulation SERPINE1 IL1B 10845889 700680 In addition , data suggest that TNF-alpha and also have stimulatory effects on PAI-1 protein secretion and may *contribute* to the elevated [PAI-1] levels observed in obesity . Positive_regulation SERPINE1 IL1B 11238529 790734 *regulates* urokinase plasminogen activator (u-PA) , u-PA receptor , soluble u-PA receptor , and [plasminogen activator inhibitor-1] messenger ribonucleic acid expression in cultured human endometrial stromal cells . Positive_regulation SERPINE1 IL1B 11238529 790743 *increased* [PAI-1] , u-PAR , and soluble u-PAR expression in a dose dependent manner , and this result was reversed by anti-IL-1beta antibody treatment . Positive_regulation SERPINE1 IL1B 11246818 764193 Finally , the *induction* of [PAI-1] activity and PAI-1 mRNA expression by was attenuated by estrogen ( 17.8+/-4.9 % , p < 0.05 and 20.9+/-5.8 % , p < 0.05 , respectively ) . Positive_regulation SERPINE1 IL1B 1368117 176477 *stimulated* the release of [PAI-1] antigen quantified by immunoassay and the kinetics of secretion were comparable on both coated and uncoated substratum . Positive_regulation SERPINE1 IL1B 14620928 1163877 ( 1 ng/ml ) and IL-6 ( 1 ng/ml ) *increased* the accumulation of [PAI-1] in the conditioned media over 24 h ( IL-1beta : 2.1 +/- 0.2 ( mean +/- SD ) fold over the control ; Positive_regulation SERPINE1 IL1B 14620928 1163880 An HMG-CoA reductase inhibitor ( mevastatin , 10 micromol/l ) attenuated the [PAI-1] production *induced* by and IL-6 . Positive_regulation SERPINE1 IL1B 14620928 1163882 Thus , 1 ) and IL-6 can *increase* [PAI-1] production in hepatic cells and 2 ) mevastatin may exert anti-thrombotic effects by decreasing the PAI-1 protein production induced by these proinflammatory cytokines . Positive_regulation SERPINE1 IL1B 16427616 1534066 *enhances* the angiotensin induced expression of [plasminogen activator inhibitor-1] through angiotensin receptor upregulation in human astrocytes . Positive_regulation SERPINE1 IL1B 16427616 1534069 After 24-h stimulation , 10 ng/ml and 10 nM angiotensin II *increased* the levels of [PAI-1] protein in astrocyte conditioned medium by 1.9-fold and 1.8-fold of the basal value , respectively . Positive_regulation SERPINE1 IL1B 18614853 2000395 and insulin also cooperatively *increased* the endogenous mRNA level of [PAI-1] . Positive_regulation SERPINE1 IL1B 19490965 2149462 Additionally , *stimulated* both HIF-1alpha and [PAI-1] in articular chondrocytes , and the IL-1beta mediated induction of PAI-1 was inhibited partly by HIF-1alpha silencing . Positive_regulation SERPINE1 IL1B 20018936 2210814 and EGR-1 is enriched at the promoters of tissue factor and [plasminogen activator inhibitor 1] in *response* to , and attenuated by PD98059 , Garcinol , and mitogen and stress activated protein kinase 1/2 short interfering RNA . Positive_regulation SERPINE1 IL1B 7525383 276914 Our objective was to delineate the mechanisms by which PGE2 and , inflammatory mediators commonly found at sites of inflammation , *regulate* the expression and synthesis of [PAI-1] in human synoviocytes . Positive_regulation SERPINE1 IL1B 7578276 329222 is a potent *inducer* of [PAI-1] in cultured HUVEC . Positive_regulation SERPINE1 IL1B 7578276 329223 Heparin , OSF , and its fragments did not suppress the *induced* release of [PAI-1] antigen . Positive_regulation SERPINE1 IL1B 8401409 230814 In contrast , [PAI-1] : Ag release was significantly *increased* by either or TNF alpha ; Positive_regulation SERPINE1 IL1B 9007614 404917 did not affect cell growth , but *stimulated* [plasminogen activator inhibitor-1] production by the colon cancer cell line . Positive_regulation SERPINE1 IL1B 9301635 453941 A23187 also abolished the increase in [PAI-1] synthesis *induced* by recombinant human , and thapsigargin exerted effects comparable to those of A23187 on PAI-1 synthesis in TNF stimulated cells . Positive_regulation SERPINE1 MAP2K6 11266465 796877 The inhibitor , PD098059 , *blocked* the growth promoting activity of uPA and [uPA-PAI-1] complex in these cells . Positive_regulation SERPINE1 MAP2K6 11719557 883724 TGF-beta1 induced [PAI-1] gene expression *requires* activity and cell-to-substrate adhesion . Positive_regulation SERPINE1 MAP2K6 11719557 883742 [PAI-1] mRNA synthesis in response to substrate attachment , like TGF-beta1 mediated induction in adherent cultures , also *required* activity as fibronectin stimulated PAI-1 expression was effectively attenuated by the MEK inhibitor PD98059 . Positive_regulation SERPINE1 MAP2K6 14631113 1170484 We found that the inhibitors , PD98059 and U0126 , *inhibited* the induction of [PAI-1] gene and protein expression during cell adhesion , PD98059 also inhibited the adhesion of cells to the culture plate , and cell adhesion elicited the kinase activities of MEK and ERK . Positive_regulation SERPINE1 MAP2K6 14631113 1170492 Based on these results , we suggest that both and ERK are *involved* in the induction of [PAI-1] gene expression during cell adhesion . Positive_regulation SERPINE1 MAP2K6 19249354 2051012 Differential *requirement* for and SMAD signaling in [PAI-1] and CTGF expression in response to microtubule disruption . Positive_regulation SERPINE1 MMP28 22798012 2645704 This effect resulted from the presence of the potent inhibitors , tissue inhibitor of metalloproteinases-1 ( TIMP-1 ) , type-1 plasminogen activator *inhibitor* ( [PAI-1] ) and thrombospondin-1 (TSP-1) in the amnion dressings , as shown by real-time fluorescence zymography and protein microarrays . Positive_regulation SERPINE1 MMP7 22798012 2645719 This effect resulted from the presence of the potent inhibitors , tissue inhibitor of metalloproteinases-1 ( TIMP-1 ) , type-1 plasminogen activator *inhibitor* ( [PAI-1] ) and thrombospondin-1 (TSP-1) in the amnion dressings , as shown by real-time fluorescence zymography and protein microarrays . Positive_regulation SERPINE1 PLAT 10764803 707570 Type 1 plasminogen activator *inhibitor* ( [PAI-1] ) , the primary inhibitor of , circulates as a complex with the abundant plasma glycoprotein , vitronectin . Positive_regulation SERPINE1 PLAT 10928471 719612 Fluvastatin inhibits basal and stimulated [plasminogen activator inhibitor 1] , but *induces* in cultured human endothelial cells . Positive_regulation SERPINE1 PLAT 11220710 787386 Insulin and *contributed* to [PAI-1] ( adj. R2 = 0.36 , p < 0.0001 ) , whereas percentage fat mass and triglycerides contributed to tPA-Ag ( adj. R2 = 0.469 , p < 0.0001 ) . Positive_regulation SERPINE1 PLAT 11744725 915975 Type 1 plasminogen activator *inhibitor* ( [PAI-1] ) , the primary inhibitor of , is found in plasma and platelets . Positive_regulation SERPINE1 PLAT 11918547 925614 Activation of protein kinase A (PKA) , however , lowered [PAI-1] secretion *induced* by uPA and , as a result of an inhibition of the PKC pathway and inhibition of Raf , Mek and MAPK phosphorylations . Positive_regulation SERPINE1 PLAT 1462840 206721 The levels of plasma TAT and significantly *increased* ( TAT = 10.9 +/- 8.3 ng/ml n = 24 M +/- SD P < 0.02 , tPA = 6.1 +/- 3.2 ng/ml n = 10 M +/- SD P < 0.01 ) , tPA PAI C and active [PAI] markedly increased ( tPA PAI C = 85.07 +/- 50.01 ng/ml n = 24 P < 0.05 , active PAI = 407.4 +/- 166.0 ng/ml n = 24 P < 0.205 ) , and PIC and D-dimer = 435.1 +/- 145.2 ng/ml n = 8 M +/- SD P < 0.001 ) in severe preeclampsia as compared with those of normal values ( TAT = 6.1 2.0 ng/ml , tPA = 3.6 +/- 1.5 ng/ml , tPA PAI C = 57.9 +/- 30.8 ng/ml , active PAI = 304.2 +/- 148.6 ng/ml , PIC = 0.49 +/- 0.24 mg/ml , D-dimer = 282.9 +/- 75.3 ng/ml ) . Positive_regulation SERPINE1 PLAT 17672283 1669059 The results showed similar concentrations of TF , TM and PAI-2 in both groups , while increased no significantly and TFPI and [PAI-1] *increased* significantly in SPE placentas . Positive_regulation SERPINE1 PLAT 18709513 1961529 aprepitant reduced activity by 55 % ( p < 0.05 ) , *increased* [PAI-1] mRNA levels by 140 % ( p < 0.05 ) , and had no affect on tPA mRNA levels . Positive_regulation SERPINE1 PLAT 1948823 171266 We measured antigen levels of two kinds of plasminogen activators , and urokinase type plasminogen activator ( UK ) , as well as their primary *inhibitor* , type-1 plasminogen activator inhibitor ( [PAI-1] ) in the tissue extracts of benign and malignant breast tumors . Positive_regulation SERPINE1 PLAT 2503591 115239 There was a significant increase of with age in both sexes , but [PAI-1] *increased* only in women . Positive_regulation SERPINE1 PLAT 2512680 121935 During the fast , the basal activity *increased* from 0.34 +/- 0.21 to 0.47 +/- 0.23 IU/ml ( p = 0.05 ) and the [PAI-1] activity decreased from 11.4 +/- 11.6 to 6.3 +/- 8.9 U/ml ( p = 0.04 ) . Positive_regulation SERPINE1 PLAT 7776475 309249 However , it is unknown whether greater constitutive expression of the gene might *increase* [plasminogen activator inhibitor-1] ( PAI-1 ) secretion , which could negate expected increases in fibrinolytic activity that accompany greater tPA protein production . Positive_regulation SERPINE1 PLAT 9345281 459356 The expression of was much higher in growth promoting than in static culture conditions ( i.e. , cultured at low density and/or on a collagen coated dish ) , and that of [PAI-1] was *regulated* in the opposite direction . Positive_regulation SERPINE1 PLAT 9562609 500605 From results obtained with cycloheximide , ongoing protein synthesis was judged to be required for both [PAI-1] induction with dexamethasone and PAI-1 suppression with IBMX , but not for the *induction* with IBMX . Positive_regulation SERPINE1 PLAU 10615432 575812 In both cell types , the secretion of [PAI-1] was *stimulated* by bFGF and PDGF , as well as by and tPA . Positive_regulation SERPINE1 PLAU 11918547 925615 Activation of protein kinase A (PKA) , however , lowered [PAI-1] secretion *induced* by and tPA , as a result of an inhibition of the PKC pathway and inhibition of Raf , Mek and MAPK phosphorylations . Positive_regulation SERPINE1 PLAU 12142372 969566 Paradoxically , high concentrations of plasminogen activator *inhibitor* ( [PAI-1] ) , an endogenous inhibitor of , also correlate with poor prognosis in patients with breast cancer , including the subgroup with node negative disease . Positive_regulation SERPINE1 PLAU 12915673 1129965 To date , the factors capable of regulating the coordinate expression of the urokinase-type plasminogen activator ( ) and its endogenous *inhibitor* , plasminogen activator inhibitor ( [PAI-1] ) , at the maternal-fetal interface remain poorly characterized . Positive_regulation SERPINE1 PLAU 15268802 1276039 In grade 3 and 4 , the plasma levels of TGFbeta and the protein expression of a-SMA and [PAI-1] in fibrotic liver tissue were significantly increased , but the protein expression of in cirrhosis liver tissue did not *increased* . Positive_regulation SERPINE1 PLAU 15995956 1430026 Expression of total was constant , but [PAI-1] levels were dramatically *increased* in plasma and in kidney homogenates during the course of staphylococcal infection . Positive_regulation SERPINE1 PLAU 18836029 1993846 further *mediates* its own expression in these cells as well as that of uPAR and [PAI-1] through induction of changes in mRNA stability . Positive_regulation SERPINE1 PLAU 1948823 171267 We measured antigen levels of two kinds of plasminogen activators , tissue type plasminogen activator (t-PA) and ( UK ) , as well as their primary *inhibitor* , type-1 plasminogen activator inhibitor ( [PAI-1] ) in the tissue extracts of benign and malignant breast tumors . Positive_regulation SERPINE1 PLAU 23835563 2839024 To investigate the prognostic value of urokinase-type plasminogen activator ( ) and its *inhibitor* , type-1 plasminogen activator inhibitor ( [PAI-1] ) , in differentiated thyroid cancer . Positive_regulation SERPINE1 PLAU 8547638 346406 Association of TNF with the agents *induced* a [PAI-1] response that was more than additive of the two , whereas the secretion of was not enhanced . Positive_regulation SERPINE1 PLAU 9089774 421883 Thus , it appears that the reduced activity observed in the cultures incubated with TGF-beta 1 is due to reduced secretion of uPA and *increased* [PAI-1] production and secretion . Positive_regulation SERPINE1 RCAN1 23825664 2808757 Overexpression of either DYRK1A or negatively regulated NFAT dependent transcriptional activity and *reduced* the upregulation of [PAI-1] levels by NGF . Positive_regulation SERPINE1 TNF 10329404 613170 *enhanced* [PAI-1] secretion and mRNA expression by approximately 2-fold . Positive_regulation SERPINE1 TNF 10329404 613171 The thiazolidinediones , troglitazone and pioglitazone , decreased basal and *stimulated* [PAI-1] secretion and mRNA expression in HUVEC in a dose dependent fashion . Positive_regulation SERPINE1 TNF 10362602 620067 and insulin , alone and synergistically , *induce* [plasminogen activator inhibitor-1] expression in adipocytes . Positive_regulation SERPINE1 TNF 10362602 620070 To identify mechanism ( s ) through which *induces* [PAI-1] , 3T3-L1 preadipocytes were differentiated into adipocytes and exposed to TNF-alpha for 24 h . TNF-alpha selectively increased the synthesis of PAI-1 without increasing activity of plasminogen activators . Positive_regulation SERPINE1 TNF 10362602 620071 Both superoxide ( generated by xanthine oxidase plus hypoxanthine ) and hydrogen peroxide were potent inducers of PAI-1 , and hydroxyl radical scavengers completely abolished the *induction* of [PAI-1] . Positive_regulation SERPINE1 TNF 10362602 620072 Because *induction* of [PAI-1] by is potentiated synergistically by insulin , both agonists appear likely to contribute to the impairment of fibrinolytic system capacity typical in obese , hyperinsulinemic patients . Positive_regulation SERPINE1 TNF 10672008 667317 In contrast to exogenously released NO that significantly reduced mostly basal PAI-1 expression , endogenously generated NO by NOS potentiated *induced* upregulation of [PAI-1] expression . Positive_regulation SERPINE1 TNF 10845889 700677 Moreover , and interkeukin-1beta ( IL-1beta ) also exerted a stimulatory effect on PAI-1 release and *increased* [PAI-1] mRNA levels . Positive_regulation SERPINE1 TNF 10845889 700679 In addition , data suggest that and IL-1beta also have stimulatory effects on PAI-1 protein secretion and may *contribute* to the elevated [PAI-1] levels observed in obesity . Positive_regulation SERPINE1 TNF 10998463 734296 In TNFalpha stimulated cells , ATOR and FLU had a modest down modulating effect ( -17 and -20 % , respectively ) on *induced* increase in [PAI-1] synthesis . Positive_regulation SERPINE1 TNF 11336794 812135 Daunorubicin attenuates *induced* biosynthesis of [plasminogen activator inhibitor-1] in human umbilical vein endothelial cells . Positive_regulation SERPINE1 TNF 11336794 812137 Fumonisin B ( 1 ) treatment restored the daunorubicin induced decrease in PAI-1 release to approximately 70 % of the control , but did not affect the *induced* increase in [PAI-1] release . Positive_regulation SERPINE1 TNF 11402043 842938 We investigated intracellular mechanisms involved in the *up-regulation* of [plasminogen activator inhibitor I] ( PAI-1 ) synthesis by human recombinant during monocyte differentiation of HL-60 cells triggered by the transforming growth factor-beta1/vitamin D ( 3) (TGF/D3 ) mixture . Positive_regulation SERPINE1 TNF 11402043 842939 Similarly , significantly *up-regulated* [PAI-1] synthesis when p70 ( S6K ) phosphorylation was inhibited by rapamycin . Positive_regulation SERPINE1 TNF 11776328 890642 [PAI-1] gene *activation* by apparently is yet to be defined for the location of the response element and/or the signaling pathway , while TGF-beta is the most important cytokine for PAI-1 transcriptional activation through its 5 ' proximal promoter . Positive_regulation SERPINE1 TNF 12506026 1070718 Using reporter gene analysis , we could identify a region in the PAI-1 promoter that contributes to basal expression as well as to *induction* of [PAI-1] in endothelial cells . Positive_regulation SERPINE1 TNF 12511973 1027604 Because TNFalpha induces PAI-1 production in endothelial cells , and NAC attenuated this response , we attempted to investigate the possible involvement of ROS in the *activation* of [PAI-1] by . Positive_regulation SERPINE1 TNF 12511973 1027606 *Upregulation* of [PAI-1] expression in endothelial cells by the stimulation with ( 50 ng/ml ) or H2O2 ( 10-200 micro M ) , observed by measurement of the antigen and mRNA levels , was reversed in the presence of NAC ( 20mM ) . Positive_regulation SERPINE1 TNF 12598326 1062057 Divergent *roles* for p55 and p75 receptors in the induction of [plasminogen activator inhibitor-1] . Positive_regulation SERPINE1 TNF 12598326 1062061 is elevated in obesity and in acute inflammatory states , and *contributes* to the elevated [plasminogen activator inhibitor-1] ( PAI-1 ) levels associated with these conditions . Positive_regulation SERPINE1 TNF 12598326 1062063 However , in lean mice , *induced* [PAI-1] expression is mediated primarily by the p55 TNFR . Positive_regulation SERPINE1 TNF 12598326 1062064 These observations suggest that the p75 TNFR may play a role in attenuating *induced* [PAI-1] mRNA expression in acute inflammatory conditions . Positive_regulation SERPINE1 TNF 12811828 1102946 This lack of effect was not due to a default of TNFalpha signaling since [PAI-1] synthesis was still stimulated in *response* to exogenous . Positive_regulation SERPINE1 TNF 12876623 1115429 [PAI-1] gene and protein expression were *induced* consistently by TGF-beta ( up to 4.0-fold ) , PDGF ( 2.1-fold ) , ( 1.7-fold ) , and thrombin ( 2.3-fold ) . Positive_regulation SERPINE1 TNF 12905793 1030913 The MAPKK inhibitor ( PD98059 , 60 mumol/L ) could markedly inhibit [PAI-1] activity and mRNA expression *induced* by ( 100 U/ml ) or mmLDL ( 50 micrograms/ml ) . Positive_regulation SERPINE1 TNF 12905793 1030915 ( 1 ) or mmLDL could *induce* [PAI-1] activity and mRNA expression in HUVECs . Positive_regulation SERPINE1 TNF 12905793 1030916 ( 2 ) Increase of [PAI-1] activity *induced* by and mmLDL was related to its mRNA expression . Positive_regulation SERPINE1 TNF 12905793 1030917 ( 3 ) The MAPK pathway may play a role in [PAI-1] expression *induced* by or mmLDL . Positive_regulation SERPINE1 TNF 1328751 197935 ( 0 to 100 ng/ml ) had no effect on t-PA synthesis , but *enhanced* [PAI-1] release in a time- and dose dependent manner ( 97 % increase of PAI-1 synthesis after a 24 hour incubation ) . Positive_regulation SERPINE1 TNF 1328751 197936 Northern blot analysis showed that *increased* the steady-state [PAI-1] mRNA levels in a time dependent manner , with a maximal effect at two hours . Positive_regulation SERPINE1 TNF 1371701 179705 The presence of both interleukin-6 (IL-6) and also *increased* UK and [PAI-1] levels , although not as dramatically as IL-1 . Positive_regulation SERPINE1 TNF 1389210 198712 HPMC [PAI-1] is *increased* by transforming growth factor-beta ( TGF-beta ) and , as is tPA release , while PAI-1 mRNA is unchanged and tPA mRNA is increased . Positive_regulation SERPINE1 TNF 1415727 201573 In dose and time-course studies , HLF plasminogen activator inhibitor-1 ( PAI-1 ) was increased by TGF-beta , whereas *induced* release of [PAI-1] into the media . Positive_regulation SERPINE1 TNF 1436316 204842 their numbers increased gradually over 24 h . also induced a progressive *increase* in [PAI] activity in normal rats . Positive_regulation SERPINE1 TNF 14534369 1165050 *induced* [PAI-1] mRNA expression and protein production in human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation SERPINE1 TNF 14534369 1165051 A specific inhibitor for p38 mitogen activated protein kinase , 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) 1H-imidazole ( SB 203580 ) , and a protein kinase C inhibitor , calphostin C , had no inhibitory effects on *induced* [PAI-1] secretion . Positive_regulation SERPINE1 TNF 14534369 1165054 A protein tyrosine kinase inhibitor , genistein , completely inhibited TNF-alpha induced PAI-1 secretion , whereas an inhibitor of extracellular signal regulated kinase ( ERK ) kinase , 2'-amino-3'-methoxyflavone ( PD98059 ) , and a nuclear factor-kappaB (NF-kappaB) inhibitor , emodin , partly inhibited *induced* [PAI-1] secretion . Positive_regulation SERPINE1 TNF 14534369 1165058 Together , PD98059 and emodin completely inhibited *induced* [PAI-1] secretion , suggesting that both NF-kappaB dependent and NF-kappaB independent pathways are involved in TNF-alpha induced signal pathway to PAI-1 production and that the latter pathway is mediated by activation of ERK . Positive_regulation SERPINE1 TNF 14534369 1165059 Furthermore , we have shown that troglitazone inhibited both *induced* [PAI-1] protein secretion and mRNA in HUVECs . Positive_regulation SERPINE1 TNF 14534369 1165060 Genistein , but neither PD98059 nor emodin , was additive to the inhibitory effect of troglitazone on *induced* [PAI-1] secretion . Positive_regulation SERPINE1 TNF 14707582 1196572 In all EC , stimulation with and lipopolysaccharide *increased* the expression of [PAI-1] , PAI-2 , and u-PA and decreased t-PA expression . Positive_regulation SERPINE1 TNF 14764800 1207440 *Induction* of [PAI-1] by could be related to restricted trophoblast invasion in preeclampsia . Positive_regulation SERPINE1 TNF 14963043 1235665 Although is a potent *inducer* of [PAI-1] expression in vitro and in vivo , the precise location of the TNFalpha response site in the PAI-1 promoter has yet to be determined . Positive_regulation SERPINE1 TNF 15677734 1402474 , but not IL-6 , *stimulates* [plasminogen activator inhibitor-1] expression in human subcutaneous adipose tissue . Positive_regulation SERPINE1 TNF 15917841 1440335 *increased* the mRNA levels of TNFalpha itself as well as IL-6 , IL-8 , IL-1beta and [PAI-1] , but not leptin . Positive_regulation SERPINE1 TNF 15990085 1429534 Thiazolidinediones inhibit *induction* of [PAI-1] independent of PPARgamma activation . Positive_regulation SERPINE1 TNF 15990085 1429535 In an endothelial cell line , Rosiglitazone ( RG ) and Pioglitazone ( PG ) inhibited *induction* of [PAI-1] by . Positive_regulation SERPINE1 TNF 15990085 1429538 The observations suggest TZDs inhibit mediated [PAI-1] *induction* independent of inducible PPARgamma activation and this may involve in the modulation of Nur77/Nurr1 expression and NP binding to the PAI-1 NBRE . Positive_regulation SERPINE1 TNF 16014034 1431804 can synergistically *enhance* this hypoxia induced [PAI-1] expression . Positive_regulation SERPINE1 TNF 16052513 1447817 We found that SalB inhibited *induced* [PAI-1] mRNA production and protein secretion in HUVECs . Positive_regulation SERPINE1 TNF 16052513 1447819 We found that the c-Jun N-terminal kinase (JNK) inhibitor , SP600125 , increased the inhibitory effects of SalB on *induced* [PAI-1] secretion , whereas the nuclear factor-kappaB (NF-kappaB) inhibitor , emodin , and the extracellular signal regulated kinase ( ERK ) inhibitor , PD98059 , did not . Positive_regulation SERPINE1 TNF 16052513 1447823 Collectively , these results indicate that the NF-kappaB and ERK-AP-1 pathways are possible targets of SalB in the regulation of *stimulated* [PAI-1] production in HUVECs . Positive_regulation SERPINE1 TNF 1618817 191373 We have previously reported that *enhances* expression of interleukin-6 , collagenase , [plasminogen activator inhibitor-1] , and basic fibroblast growth factor genes in human omental microvascular endothelial ( HOME ) cells in culture . Positive_regulation SERPINE1 TNF 16190362 1462607 Hypoxia , and their combination *induced* a 2.8-fold , a 1.8-fold , and a 4.6-fold increase in [PAI-1] protein secretion , and produced a 3.6-fold , a 3.3-fold , and a 12.1-fold increase at the PAI-1 mRNA level , respectively . Positive_regulation SERPINE1 TNF 16279946 1480584 We have shown that *induced* expression and gene transcription of [PAI-1] involves a regulatory region present in segment -664/-680 of the PAI-1 promoter . Positive_regulation SERPINE1 TNF 16279946 1480587 We show that *activation* of [PAI-1] gene by and reactive oxygen species is mediated by interaction of NF-kappaB with the cis acting element located in the -675 4G/5G insertion/deletion in the PAI-1 promoter . Positive_regulation SERPINE1 TNF 16338458 1503930 *mediated* induction of [PAI-1] restricts invasion of HTR-8/SVneo trophoblast cells . Positive_regulation SERPINE1 TNF 16458614 1534488 Notoginsenoside R1 from Panax notoginseng inhibits *induced* [PAI-1] production in human aortic smooth muscle cells . Positive_regulation SERPINE1 TNF 16458614 1534490 These results suggest that notoginsenoside R1 inhibits *induced* [PAI-1] overexpression in HASMCs by suppressing ERK and PKB signaling pathways . Positive_regulation SERPINE1 TNF 1655042 166202 Moreover , when PK-C was down-regulated by PMA pretreatment , subsequent *induction* of [PAI-1] by transforming growth factor beta ( TGF beta ) and was unaltered , and induction by lipopolysaccharide (LPS) was decreased by only 50 % . Positive_regulation SERPINE1 TNF 1655042 166203 Agents which increase cAMP , ( e.g. , forskolin and isobutylmethylxanthine ) blocked the *induction* of [PAI-1] synthesis by PMA , LPS , TGF beta and suggesting that induction may occur by lowering cAMP . Positive_regulation SERPINE1 TNF 16952378 1639507 ( 1-10 ng/ml ) dose-dependently *increased* interleukin (IL)-6 and [plasminogen activator inhibitor-1] ( PAI-1 ) secretion from 3T3-L1 adipocytes , while decreased adiponectin secretion . Positive_regulation SERPINE1 TNF 17046548 1635756 *induced* production of [plasminogen activator inhibitor 1] and its regulation by pioglitazone and cerivastatin in a nonmalignant human hepatocyte cell line . Positive_regulation SERPINE1 TNF 17046548 1635758 A thiazolidinedione , pioglitazone , reduced *induced* [PAI-1] production by 32 % , via protein kinase C- and nuclear factor-kappaB dependent pathways . Positive_regulation SERPINE1 TNF 17046548 1635759 The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor cerivastatin inhibited *induced* [PAI-1] production by 59 % , which was reversed by coincubation with mevalonic acid . Positive_regulation SERPINE1 TNF 17172275 1717231 The *induction* of [PAI-1] by and insulin is mediated , in part , by ERK and p38 MAPK . Positive_regulation SERPINE1 TNF 18078928 1854445 Cross talk of tumor necrosis factor-alpha and the renin-angiotensin system in *induced* [plasminogen activator inhibitor-1] production from hepatocytes . Positive_regulation SERPINE1 TNF 18078928 1854446 We next examined the role of the renin-angiotensin system on *induced* [PAI-1] production in the nonmalignant human hepatocyte cell line THLE-5b . Positive_regulation SERPINE1 TNF 18078928 1854447 Moreover , angiotensin AT(1) receptor antagonist dose-dependently inhibited *induced* [PAI-1] production . Positive_regulation SERPINE1 TNF 18180317 1856496 Taken together , these observations suggest that GLP-1 inhibits mediated [PAI-1] *induction* in vascular endothelial cells , and this effect may involve Akt mediated signalling events and the modulation of Nur77 expression and NP binding to the PAI-1 NBRE . Positive_regulation SERPINE1 TNF 18367541 1938141 It also enhanced hypoxia- , TNF-alpha- and hypoxia plus *stimulated* [PAI-1] expression at the mRNA and protein levels . Positive_regulation SERPINE1 TNF 18390808 1925675 The prolonged production *enhanced* [PAI-1] production after RAN cotreatment , and this is important for the hepatotoxicity . Positive_regulation SERPINE1 TNF 18700166 1973937 Ghrelin attenuates [plasminogen activator inhibitor-1] production *induced* by in HepG2 cells via NF-kappaB pathway . Positive_regulation SERPINE1 TNF 18700166 1973938 Ghrelin , a recently described orexigenic peptide hormone , attenuates [PAI-1] *induced* by in the human hepatoma cell line ( HepG2 ) . Positive_regulation SERPINE1 TNF 18700166 1973939 Exposure to TNF-alpha ( 1 ng/ml ) for 24h caused a significant increase in PAI-1 mRNA expression and protein secretion , as evaluated by RT-PCR and ELISA , but pretreatment with ghrelin ( 1-100 ng/ml ) inhibited both basal and *induced* [PAI-1] release in a dose and time dependent manner in HepG2 . Positive_regulation SERPINE1 TNF 18700166 1973940 The results indicate that ghrelin inhibits both basal and *induced* [PAI-1] production via NF-kappaB pathway in HepG2 cells , and suggest that the peptide plays a therapeutic role in atherosclerosis , especially in obese patients with insulin resistance , in whom ghrelin levels were reduced . Positive_regulation SERPINE1 TNF 18978303 2071131 The results indicated that dynasore enhanced transforming growth factor (TGF)-beta(1)- and *induced* [PAI-1] protein expression in a concentration dependent manner . Positive_regulation SERPINE1 TNF 19153071 2079190 Dexamethasone enhances basal and *stimulated* production of [PAI-1] via the glucocorticoid receptor regardless of 11beta-hydroxysteroid dehydrogenase 2 status in human proximal renal tubular cells . Positive_regulation SERPINE1 TNF 19153071 2079194 DXA further increased *stimulated* [PAI-1] expression via the GR . Positive_regulation SERPINE1 TNF 1918385 168397 However , the greatest responses to TGF-beta were observed in adipose tissue and the kidney , while LPS and strongly *stimulated* [PAI-1] gene expression in the liver , kidney , lung , and adrenals . Positive_regulation SERPINE1 TNF 19217919 2086509 Similarly , CNP and the inhibitors of ERK1/2 ( PD098059 ) and PI3K ( LY294002 ) attenuated [PAI-1] expression *induced* by . Positive_regulation SERPINE1 TNF 19450557 2090765 Shear stress and additively *induced* [PAI-1] , whereas shear stress blocked the cytokine effect on t-PA and u-PA . Positive_regulation SERPINE1 TNF 2109778 131195 Neither the LPS- or *induced* expression of [PAI-1] nor the dLPS inhibition of the LPS response was mediated by prostanoids . Positive_regulation SERPINE1 TNF 21186817 2378857 p-Coumaric acid , quercetin , and resveratrol demonstrated inhibitions of *induced* changes in levels of monocyte chemoattractant protein-1 ( MCP-1 ) , [plasminogen activator inhibitor-1] ( PAI-1 ) , and intracellular reactive oxygen species ( ROS ) in 3T3-L1 adipocytes . Positive_regulation SERPINE1 TNF 21212994 2726119 Furthermore , [PAI-1] was also upregulated in the *presence* of and glucose . Positive_regulation SERPINE1 TNF 21212994 2726123 *induced* Egr-1 protein expression and [PAI-1] levels through the ERK1/2 pathway . Positive_regulation SERPINE1 TNF 21494547 2418110 Mice exposed to inhaled PM exhibited a *dependent* increase in [PAI-1] and an IL-6 dependent activation of coagulation . Positive_regulation SERPINE1 TNF 22019926 2513628 *had* no effect on [PAI-1] production or fibrin deposition . Positive_regulation SERPINE1 TNF 22572461 2631990 In cultured human endothelial cells , GlcN time- and concentration-dependently increased [PAI-1] protein level that was further *enhanced* by , which was accompanied by a transient synergistic activation of p38mapk . Positive_regulation SERPINE1 TNF 22572461 2631992 The *stimulation* of [PAI-1] by GlcN alone or by GlcN and in combination was inhibited by the specific inhibitor of p38mapk , but not that of JNK or ERK1/2 . Positive_regulation SERPINE1 TNF 22658637 2643602 Simvastatin also attenuated the increase in expression and secretion of [PAI-1] *induced* by ( 16898.6 ± 1663.3 vs 12922.1 ± 843.9 and 5.19 ± 3.12 vs 0.59 ± 0.16 , respectively p < 0.05 ) , but under baseline conditions had no effect on the expression or secretion of PAI-1 . Positive_regulation SERPINE1 TNF 22819264 2646089 Pretreatment with CORM-2 significantly inhibited induced TF and [PAI-1] *up-regulation* in HUVECs , and LPS induced TF expression in PBMCs . Positive_regulation SERPINE1 TNF 22819264 2646103 CORM-2 suppresses *induced* TF and [PAI-1] up-regulation , and MAPKs and NF-?B signaling pathways activation by TNF-a in HUVECs . Positive_regulation SERPINE1 TNF 23220618 2736575 In addition , treatment with IMG and hyperoside resulted in inhibition of *induced* production of [PAI-1] , and treatment with IMG resulted in significant reduction of the PAI-1 to t-PA ratio . Positive_regulation SERPINE1 TNF 23558707 2823039 Furthermore , histone deacetylase 2 (HDAC2) knockdown by RNA interference , a mimic of oxidative-stress dependent HDAC2 reduction , enhanced *induced* [PAI-1] induction ( half maximal effective concentration [ EC50 ] , 0.64 ± 0.19 ng/mL in HDAC2-KD , 7.64 ± 3.70 ng/mL in control ) concomitant with enhancement of NF-?B p65 acetylation and NF-?B DNA binding activity . Positive_regulation SERPINE1 TNF 23921304 2861632 ( - ) -Epigallocatechin gallate inhibits *induced* [PAI-1] production in vascular endothelial cells . Positive_regulation SERPINE1 TNF 23921304 2861633 However , it is not known whether or not EGCG inhibits [PAI-1] production *induced* by in endothelial cells . Positive_regulation SERPINE1 TNF 23921304 2861634 This study tested the hypothesis that EGCG might have an inhibitory effect on [PAI-1] production *induced* by . Positive_regulation SERPINE1 TNF 23921304 2861635 The results showed that *increased* [PAI-1] production in both a dose dependent and time dependent manner , and EGCG prevented TNF-a mediated PAI-1 production and reduced phosphorylation of ERK1/2 . Positive_regulation SERPINE1 TNF 23921304 2861636 The ERK1/2 inhibitor , PD98059 ( 20 µmol/L ) , downregulated *induced* [PAI-1] expression 57.69 ± 2.46 % ( P < 0.01 ) , but had no effect in cells pretreated with EGCG . Positive_regulation SERPINE1 TNF 23973654 2861990 In addition , treatment with PLT resulted in the inhibition of *induced* production of [PAI-1] and in the significant reduction of the PAI-1 to t-PA ratio . Positive_regulation SERPINE1 TNF 24228603 2868714 In addition , treatment with ESM , but not SM , resulted in the inhibition of *induced* production of [PAI-1] , and treatment with ESM resulted in a significant reduction of the PAI-1 to t-PA ratio . Positive_regulation SERPINE1 TNF 2460966 100129 Cultured human endothelial cells increase their [PAI-1] production upon *stimulation* with LPS and , agents that are known to cause an increase in PAI-1 levels in vivo . Positive_regulation SERPINE1 TNF 3140909 99637 The monokine ( human recombinant TNF ) *increased* the production of [PAI] by cultured human endothelial cells from umbilical vein ( twofold ) and from foreskin microvessles ( four to eight fold ) . Positive_regulation SERPINE1 TNF 3140909 99638 The *stimulation* of [PAI] activity by was seen at 4 U/mL and reached a maximum at 500 U/mL . Positive_regulation SERPINE1 TNF 3140909 99667 Therefore , it is most likely that vascular endothelial cells contribute to the increased amount of circulating [PAI] *induced* by in vivo . Positive_regulation SERPINE1 TNF 3144762 101956 ( 1-1000 pg/ml ) *induced* a dose dependent increase in [PAI] level in the supernatant from 6 to 25 U/ml as estimated against urokinase . Positive_regulation SERPINE1 TNF 7545393 318532 We show that pyrrolidine dithiocarbamate strongly reduces the mediated *induction* of E-selectin , VCAM-1 , ICAM-1 , [PAI-1] , tissue factor , IL-8 and I kappa B-alpha . Positive_regulation SERPINE1 TNF 7561050 324171 In contrast , the *induced* expression of [plasminogen activator inhibitor-1] and the constitutive expression of ICAM-2 were unaffected . Positive_regulation SERPINE1 TNF 7778058 309336 Stimulation with LPS or *increased* the expression of [PAI-1] , u-PA and PAI-2 in HUVEC and HSVEC , while the t-PA response differed between the two cell types . Positive_regulation SERPINE1 TNF 7949170 277325 In contrast to *induced* [PAI-1] production , the transcription and synthesis of urokinase-type plasminogen activator ( u-PA ) was not inhibited by genistein . Positive_regulation SERPINE1 TNF 8156339 253249 Thus may *mediate* increased [PAI-1] release in inflamed peritoneum . Positive_regulation SERPINE1 TNF 8156339 253250 significantly *increased* the mean ( s.e.m. ) release of [PAI-1] by human peritoneal mesothelial cells in vitro at 4 h ( control 1.84 ( 0.17 ) ng/micrograms versus TNF 2.37 ( 0.17 ) ng/micrograms , P < 0.05 ) , 6 h ( 2.53 ( 0.09 ) versus 3.88 ( 0.46 ) ng/micrograms , P < 0.05 ) , 18 h ( 0.50 ( 0.02 ) versus 1.04 ( 0.11 ) ng/micrograms , P < 0.05 ) and 24 h ( 0.87 ( 0.05 ) versus 1.35 ( 0.11 ) ng/micrograms , P < 0.05 ) . Positive_regulation SERPINE1 TNF 8401409 230813 In contrast , [PAI-1] : Ag release was significantly *increased* by either IL-1 beta or ; Positive_regulation SERPINE1 TNF 8456426 215460 IL-1 alpha and *increased* the synthesis of PAI-2 and [PAI-1] by EC in a dose dependent manner . Positive_regulation SERPINE1 TNF 8547638 346402 alone *induced* a more marked accumulation of [PAI-1] than of uPA . Positive_regulation SERPINE1 TNF 8547638 346405 Association of with the agents *induced* a [PAI-1] response that was more than additive of the two , whereas the secretion of uPA was not enhanced . Positive_regulation SERPINE1 TNF 8550848 346964 Endotoxin also *induced* [PAI-1] in endothelial cells , while additionally induced it in smooth muscle cells . Positive_regulation SERPINE1 TNF 8603504 350754 Enzyme linked immunosorbent assay of culture media showed that ( 10 ng/mL ) *increased* [PAI-1] secretion by 4.2 fold compared with control ( 105.5 +/- 9.6 ) versus 24.9 +/- 1.7 ng/mL , n = 3 ) . Positive_regulation SERPINE1 TNF 8603504 350756 In addition , the *induction* of [PAI-1] by and plasminogen suggests a negative feedback mechanisms limit both plasmin mediated and MMP mediated matrix degradation . Positive_regulation SERPINE1 TNF 8805664 382282 However , IFN-gamma did not appear to affect IL-1 alpha- and *induced* levels of [PAI-1] protein or mRNA in these cells . Positive_regulation SERPINE1 TNF 8945961 400366 We found that the isoflavone compound genistein ( 25 micrograms/ml ) prevented the *induced* expression of [PAI-1] and TF while also slightly counteracting the decrease in t-PA synthesis . Positive_regulation SERPINE1 TNF 8945961 400367 The protein kinase C inhibitor R0-318220 ( 3 microM ) only moderately opposed the *induced* changes in t-PA and [PAI-1] synthesis but completely prevented the induction of TF mRNA . Positive_regulation SERPINE1 TNF 9048615 416829 *regulates* [plasminogen activator inhibitor-1] in rat testicular peritubular cells . Positive_regulation SERPINE1 TNF 9132278 419566 This increase in *contributes* to the insulin resistance , elevated [plasminogen activator inhibitor-1] ( PAI-1 ) levels , and cardiovascular complications associated with obesity and noninsulin dependent diabetes ( NIDDM ) . Positive_regulation SERPINE1 TNF 9186610 436874 Since both TNF-alpha and insulin are known to increase in obesity , the elevated levels of [PAI-1] observed in the plasma of obese individuals may *result* from and/or insulin induction of PAI-1 in the adipose tissue itself . Positive_regulation SERPINE1 TNF 9259107 448586 Although a recent study insists that inhibition of does not *reduce* the induction of [PAI-1] by endotoxin in rats , we imagine that TNF alpha is involved in the induction of PAI-1 by endotoxin , because endotoxin treatment induces TNF alpha and administration of TNF alpha induces PAI-1 both in vitro and in vivo . Positive_regulation SERPINE1 TNF 9301635 453936 Intracellular calcium mobilization suppresses the *stimulated* synthesis of [PAI-1] in human endothelial cells . Positive_regulation SERPINE1 TNF 9301635 453938 alone *increased* [PAI-1] accumulation in the culture medium in a time- and dose dependent fashion , but this increase was abolished when A23187 was added simultaneously with TNF . Positive_regulation SERPINE1 TNF 9301635 453939 Comparable inhibitory effects on PAI-1 protein synthesis were observed when A23187 was added 7 hours after the onset of TNF stimulation , strongly suggesting a posttranscriptional inhibitory action of calcium signaling on *stimulated* [PAI-1] synthesis . Positive_regulation SERPINE1 TNF 9301635 453940 Chelation of extracellular calcium by EGTA did not prevent the A23187 induced inhibition of *stimulated* [PAI-1] protein synthesis , emphasizing the role of internal calcium stores in the inhibition of PAI-1 synthesis . Positive_regulation SERPINE1 TNF 9580327 499265 The elevated in the placenta may *induce* [PAI-1] and TF , and thus promote the thrombotic alterations associated with preeclampsia . Positive_regulation SERPINE1 TNF 9688934 522679 The secretion of uPA and [plasminogen activator inhibitor-1] from HLMECs was also *enhanced* by and IL-2 . Positive_regulation SERPINE1 TNF 9824663 549138 *induced* release of [plasminogen activator inhibitor-1] from human umbilical vein endothelial cells : involvement of intracellular ceramide signaling event . Positive_regulation SERPINE1 TNF 9824663 549139 We have investigated the biochemical mechanism of *induced* release of [plasminogen activator inhibitor-1] ( PAI-1 ) from human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation SERPINE1 TNF 9824663 549140 Here , N-acetylsphinganine ( C2-dihydroceramide ) was found to specifically suppress both C2-ceramide- and *induced* increase in [PAI-1] release from HUVEC without affecting the control PAI-1 release . Positive_regulation SERPINE1 TNF 9824663 549141 The increase in PAI-1 release by this mechanism was suppressed by a cyclooxygenase inhibitor , aspirin , whereas the inhibitor did not affect *induced* increase in [PAI-1] release . Positive_regulation SERPINE2 IL1B 11814314 892820 We have examined expression of the components of the plasminogen activation system in human astrocytoma U373-MG cells and found that , tumour necrosis factor alpha TNF-alpha ) , interferon gamma (INF-gamma) and epidermal growth factor (EGF) specifically *regulate* the expression of tissue-type plasminogen activator (t-PA) , urokinase-type plasminogen activator ( u-PA ) , plasminogen activator inhibitor type 1 ( PAI-1 ) and [protease nexin-1 (PN-1)] . Positive_regulation SERPINE2 PLAT 15128599 1279534 In cultures of cells from small follicles , secreted levels increased with time of culture for antral but not basal cells , and [SerpinE2] levels *increased* with time for basal but not antral cells . Positive_regulation SERPINE2 TNF 11814314 892817 We have examined expression of the components of the plasminogen activation system in human astrocytoma U373-MG cells and found that interleukin 1beta (IL-1beta) , tumour necrosis factor alpha ) , interferon gamma (INF-gamma) and epidermal growth factor (EGF) specifically *regulate* the expression of tissue-type plasminogen activator (t-PA) , urokinase-type plasminogen activator ( u-PA ) , plasminogen activator inhibitor type 1 ( PAI-1 ) and [protease nexin-1 (PN-1)] . Positive_regulation SERPINE2 TNF 16697375 1563811 Here , we investigated whether *induced* expression of [SerpinE2] is mediated by the nuclear factor-kappaB (NF-kappaB) p65 subunit . Positive_regulation SERPINE2 TNF 16697375 1563812 These results indicated that activation of NF-kappaB p65 plays an important role in *induced* expression of [SerpinE2] . Positive_regulation SERPINF1 TNF 24367624 2881812 In adipocytes , [PEDF] was *induced* by through activation of NF-?B . Positive_regulation SERPINF1 TP63 15856012 1432692 Collectively , and p73 may be *involved* in cell fate by inducing [PEDF] expression . Positive_regulation SERPINF2 CTGF 20008146 2191217 Moreover , we found that *induced* the expression of [alpha2AP] through both the extracellular signal regulated kinase 1/2 ( ERK1/2 ) and c-Jun N-terminal kinase (JNK) pathways in fibroblasts . Positive_regulation SERPINF2 IL1R2 12206839 983458 expression on blood lymphocytes *increased* significantly [PLI] and PBI . Positive_regulation SERPING1 TNF 9777421 540262 Interferon-gamma and alpha (IFN) , colony stimulating factor-1 , interleukin-6 (IL-6) and all *induce* [C1-INH] synthesis in a variety of cell types . Positive_regulation SERPINH1 IL1B 11994473 939053 In the present study , using human embryonic lung fibroblast cells , we first disclosed that both TGF-beta and *induced* [HSP47] synthesis . Positive_regulation SERPINH1 MAP2K6 17367817 1727480 The mitogen activated protein kinase (MAPK) signaling pathway in NHLF was activated by HNP-1 stimulation , but inhibitor of ( PD98059 ) did not *block* HNP-1 induced [HSP47] protein production . Positive_regulation SERPINH1 MAP2K6 18221324 1876748 Taken together , HSP47 is significantly upregulated in OSF from areca quid chewers and [HSP47] expression induced by arecoline in fibroblasts may be *mediated* by , PI3K , and COX-2 signal transduction pathways . Positive_regulation SESN3 FOXO1 20412774 2246455 First , *induces* [Sestrin3 (Sesn3)] gene expression . Positive_regulation SET EPHB2 15703833 1372695 [I-2PP2A/SET] suppressed *activation* of following EGF stimulation but did not affect activation levels of stress kinases , JNK and p38 . Positive_regulation SETBP1 AGR2 16030224 1436081 Therefore , the *mediated* post-exponential-phase increase in [seb] transcription results from the Agr system 's inactivation of Rot repressor activity . Positive_regulation SETBP1 IL1B 9267623 449676 Culture supernatants were assayed for cytokines IL-1 beta , IL-6 and chemotactic agents IL-8 and LTB4 [SEB] *induced* the production of and IL-8 . Positive_regulation SETBP1 TNF 10569782 568066 TNF-alpha production induced by SEB in mixed cultures is more closely associated with T cells than with monocytes : ( i ) a TCR-binding-site mutant of SEB ( N23F ) is less active in TNF-alpha induction than an MHC class II receptor-binding-site mutant ( F44R ) , and ( ii ) flow cytometric analysis indicated that [SEB] *induced* production in T cells but not in monocytes . Positive_regulation SETBP1 TNF 10996392 733875 PEA/LPS- , [PEA/SEB-] or PEA/rmuTNF induced liver injury was *mediated* by both , i.e . TNFR1 and TNFR2 . Positive_regulation SETBP1 TNF 14560009 1154039 We demonstrate here that superantigen [Staphylococcus enterotoxin B (SEB)] *induced* a dramatic upregulation of FasL , TRAIL , and mRNA expression and function in IEC from BALB/c and C57BL/6 mice . Positive_regulation SETBP1 TNF 20634937 2292164 [SEB] *induced* low levels of , IL-1 , IFNgamma , MIP-2 , and LPS synergized with SEB in the expression of these cytokines and that of IL-6 and MCP-1 . Positive_regulation SETBP1 TNF 8299910 248596 [SEB] *induced* the production of and IFN-gamma in a dose dependent manner from splenic mononuclear cells in vitro . Positive_regulation SETBP1 TNF 9260332 448723 Anti-CD3 mAb as well as [SEB] or Con A *induced* the release of systemic , interferon gamma (IFN gamma) , and various other cytokines . Positive_regulation SETBP1 TNFSF10 14560009 1154040 We demonstrate here that superantigen [Staphylococcus enterotoxin B (SEB)] *induced* a dramatic upregulation of FasL , , and TNF mRNA expression and function in IEC from BALB/c and C57BL/6 mice . Positive_regulation SETD1A TNF 16386180 1494193 Cytokines are the direct mediators for multiple organ failure (MOF) , and [MOF] is *triggered* by and a cascade of cytokine release , with a prolonged high-expression of IL-6 . Positive_regulation SETD2 ANGPT1 21200018 2414290 *increased* the synthesis of [HIF-1a] by activating mammalian target of rapamycin (mTOR) in hypoxic endothelium . Positive_regulation SETD2 CTGF 23530034 2777439 Notably , silencing of endogenous CCN2 increased HIF-1a levels and its target gene expression , suggesting a *role* for in controlling basal [HIF-1a] levels . Positive_regulation SETD2 DAPK1 24337450 2895133 In the present study , we investigated whether overexpression may *mediate* vascular endothelial growth factor ( VEGF ) [/hypoxia-inducible factor-1a (HIF-1a)] expression and angiogenic activity in the human carcinoma cell model system . Positive_regulation SETD2 EGLN3 20978507 2344220 *regulates* degradation of [HIF-1a] . Positive_regulation SETD2 EGLN3 21620138 2436371 Interaction of PKM2 with *enhances* PKM2 binding to [HIF-1a] and PKM2 coactivator function . Positive_regulation SETD2 EGLN3 22451659 2594896 In contrast , in hypoxia , *enhances* [HIF-1a] transcriptional activity without affecting protein levels . Positive_regulation SETD2 EGLN3 22488178 2643143 In contrast , silencing of up-regulated HIF-2a but *reduced* [HIF-1a] , thereby decreasing the expression of HIF regulated genes . Positive_regulation SETD2 EPHB2 12447987 1032129 *Role* of and calcium in the hypoxia induced activation of [HIF-1] . Positive_regulation SETD2 EPHB2 21320746 2398915 Furthermore , the expression of [HIF-1a] induced by SCF is not *dependent* on the oxygen level , but rather on both the PI3K/Akt and signaling pathways . Positive_regulation SETD2 EPHB2 21544242 2424334 The AKT and inhibitors , LY294002 and U0126 , *suppressed* [HIF-1a] and VEGF expression and angiogenesis . Positive_regulation SETD2 EPHB2 21882253 2668079 Celecoxib inhibited basal and EGF stimulated proliferation , hypoxia related [HIF-1a] recruitment/stabilization as well as hypoxia- and EGF dependent *activation* of and PI3K . Positive_regulation SETD2 EPHB2 21980400 2493075 PI3K and induced Rac1 activation *mediates* hypoxia induced [HIF-1a] expression in MCF-7 breast cancer cells . Positive_regulation SETD2 EPHB2 22613537 2603806 Inhibition of significantly *reduced* activated HIF-1a protein and the nuclear translocation of HIF-1a , whereas [HIF-1a] mRNA levels were not affected . Positive_regulation SETD2 EPHB2 22926523 2818151 In conclusion , our findings provide evidence that GAB2 is a novel regulator of tumor angiogenesis in NRAS-driven melanoma through regulation of [HIF-1a] and VEGF expressions *mediated* by signaling . Positive_regulation SETD2 EPHB2 23007029 2706383 Activation ( phosphorylation ) of 1/2 and Akt , and *induction* of [hypoxia-inducible factor (HIF)-1a] were assessed in the cortex , one of the main structures affected by HI and protected by HPC , at different time points after reoxygenation in wild-type ( WT ) and GPx1 overexpressing animals . Positive_regulation SETD2 F2R 20857420 2375600 However , we observed that thrombin induced [HIF-1a] increased Twist mRNA and its protein level was *mediated* by the modulation of activation and the HIF-1a translational pathway . Positive_regulation SETD2 FAS 21454809 2427897 Compared with typical NO donors such as spermine-NONOate and deta-NONOate , NO ( 2 ) <-FAs> were slightly less potent *inducers* of EC migration and [HIF-1a] expression . Positive_regulation SETD2 FOXO1 18845636 2028575 These results indicate that FSH stimulated [HIF-1] activation leading to up-regulation of targets such as vascular endothelial growth factor *requires* not only PI3-kinase/AKT mediated activation of mammalian target of rapamycin as well as phosphorylation of and possibly MDM2 but also a protein ( kinase ) activity that is inhibited by the classic ERK kinase inhibitor PD98059 but not ERK1/2 or 5 . Positive_regulation SETD2 IL1B 15665520 1365585 [HIF-1] is also *activated* by and may thus be involved in the stimulation of VEGF production by this cytokine . Positive_regulation SETD2 IL1B 15930287 1414475 Herein , we show that apart from hypoxia , the proinflammatory cytokine *induced* the expression of ADM mRNA through activation of [HIF-1] under normoxic conditions and enhanced the hypoxia induced expression in the human ovarian carcinoma cell line OVCAR-3 . Positive_regulation SETD2 IL1B 16770323 1585527 3. In human keratinocyte cultures ( HaCaT cells ) , ginsenoside Rb1 ( 100 fg ml(-1) to 1 ng ml(-1) ) enhanced VEGF production *induced* by and expression of [hypoxia-inducible factor (HIF)-1alpha] . Positive_regulation SETD2 MAOA 24865426 2945507 Here , we found that functions to induce epithelial-to-mesenchymal transition ( EMT ) and *stabilize* the transcription factor [HIF1a] , which mediates hypoxia through an elevation of ROS , thus enhancing growth , invasiveness , and metastasis of PCa cells . Positive_regulation SETD2 MAP2K6 20724477 2330240 These translational signal events and [HIF-1a] protein level were *suppressed* by inhibitors of phosphatidylinositol 3-kinase (PI3K) , , and mTOR , suggesting that the PI3K/Akt/mTOR and MEK/ERK pathways are involved in a translational increase in HIF-1a . Positive_regulation SETD2 MAP2K6 21320746 2398923 Furthermore , the expression of [HIF-1a] induced by SCF is not *dependent* on the oxygen level , but rather on both the PI3K/Akt and signaling pathways . Positive_regulation SETD2 MAP2K6 22926523 2818157 In conclusion , our findings provide evidence that GAB2 is a novel regulator of tumor angiogenesis in NRAS-driven melanoma through regulation of [HIF-1a] and VEGF expressions *mediated* by signaling . Positive_regulation SETD2 PGC 22266669 2580054 Under the condition of hypoxia concomitant with serum deprivation , the overexpression of in MSCs *resulted* in a higher expression level of [hypoxia-inducible factor-1a (Hif-1a)] , a greater ratio of B-cell lymphoma leukemia-2 (Bcl-2)/Bcl-2 associated X protein (Bax) , and a lower level of caspase 3 compared with the controls , followed by an increased survival rate and an elevated expression level of several proangiogenic factors . Positive_regulation SETD2 SPHK1 21392092 2453288 Consistently , siRNA-SPHK1 and sphingosine kinase inhibitor (SKI) effectively blocked the expression of HIF-1a , phospho-AKT and vascular endothelial growth factor ( VEGF ) production in PC-3 cells under hypoxia , suggesting the *role* of in melatonin inhibited [HIF-1a] accumulation . Positive_regulation SETD2 TGM2 23185316 2704437 constitutively *activates* [HIF-1a] promoter and nuclear factor-?B via a non-canonical pathway . Positive_regulation SETD2 TLR7 22728164 2676092 Furthermore , we observed that nitric oxide synthase activity was dependent on mTOR in these myeloid cells and involved in [HIF-1a] accumulation *mediated* by endosomal triggering in THP-1 cells as well as IgE dependent basophil , but not mast cell , responses . Positive_regulation SETD2 TNF 20709868 2323462 Using human carotid artery smooth muscle cells ( CASMCs ) , we demonstrated that ( 100 ng/ml ) *activates* [HIF-1] ( HIF-1a expression ) , leading to increased CASMC proliferation ( Ki-67 and PCNA staining ) and resistance to mitochondrial dependent apoptosis [ tetramethylrhodamine methyl ester perchlorate ( TMRM ) , terminal deoxynucleotide transferase mediated dUTP nick end labeling ( TUNEL ) , annexin-V staining ] . Positive_regulation SETD2 TNF 24213609 2897242 Both hypoxia and inflammatory factor TNF-a regulate gene expression of [HIF-1a] , but how RTEF-1 and coordinately *regulate* HIF-1a gene transcription is unclear . Positive_regulation SETD2 TNF 24213609 2897248 Moreover , expression of RTEF-1 decreased *induced* [HIF-1a] promoter activity , IL-1ß , and IL-6 mRNA levels in cells ; Positive_regulation SETD2 UNC5B 23599441 2783858 Indeed , using promoter-luciferase reporter genes , we show that Ntn1- and activities are induced by oxidized low-density lipoprotein and *require* [HIF-1a] . Positive_regulation SETD7 TNF 19262565 2062984 Lysine methyltransferase [Set9] physically associates with RelA in vitro and in vivo in *response* to stimulation . Positive_regulation SF1 EPHB2 17312106 1699614 The [TLR2-BBP] *induced* weak activation of p38 , but not or cytokine mRNA . Positive_regulation SF3B1 IFI27 23594796 2810353 ( CDKN1B ) arrests cells in G1 , and [SAP155] ( SF3B1 ) , a subunit of the essential splicing factor 3b (SF3b) subcomplex of the spliceosome , is *required* for proper P27 pre-mRNA splicing . Positive_regulation SFN IFI27 20642839 2297562 [SFN] *induced* the expression of p21/CIP1 and , and inhibited the expression of cyclin D1 . Positive_regulation SFRP1 FOXA1 16835437 1587641 is the earliest zygotic determinant of the ascidian anterior ectoderm and directly *activates* [Ci-sFRP1/5] . Positive_regulation SFRP1 FOXA1 19248777 2062636 is the earliest zygotic determinant of the ascidian anterior ectoderm and directly *activates* [Ci-sFRP1/5] . Positive_regulation SFRP1 MSX1 19815336 2209325 We show that *induces* the expression of four different Wnt pathway inhibitor genes : Dickkopf 1-3 (DKK1-3) and [secreted frizzled related protein 1] ( SFRP1 ) , and provide evidence that high expression of two of these genes correlates with good prognosis . Positive_regulation SFRP1 TNF 22313323 2658205 In conclusion , CSF-1 and EMAP-II may contribute to the reduced SFRP-1 expression seen on day 3 , while may *contribute* to the reduced [SFRP-1] expression at day 9 . Positive_regulation SFTPA2 TNF 8698480 372892 On the other hand , [SPA] *induced* the release of IL-1 , IL-6 , and and enhanced the expression of IL-1alpha , IL-1beta , IL-6 , and TNF alpha (TNF-alpha) mRNAs . Positive_regulation SFTPB FOXA1 7958446 278167 We show that the SPB-f2 sequence is recognized by both and HFH-8 proteins and that these cDNA expression vectors *activate* the [SPB] promoter in cotransfection assays through the HNF-3 consensus sequence . Positive_regulation SFTPB FOXA1 7958446 278168 Our results suggest that [SPB] promoter activity is *regulated* by and HFH-8 proteins in a cell type-specific manner . Positive_regulation SFTPC CTGF 15946238 1420871 Northern blot analysis showed that [SPC] markedly *induced* mRNA expression in a dose- and time dependent manner . Positive_regulation SFTPC CTGF 15946238 1420873 Consistent with this result , Western blot analysis also showed that [SPC] significantly *induced* the production . Positive_regulation SFTPC EPHB2 17481939 1750527 Pretreatment of the cells with U0126 , an MEK inhibitor , markedly attenuated the SPC induced expression of FN and delayed phosphorylation of Smad2 , suggesting that is *involved* in the [SPC] induction of FN expression through activation of Smad2 . Positive_regulation SFTPC IL1B 18523246 1922691 LPC or [SPC] alone *induced* the release of precursor ( pro-IL-1beta ) and mature ( mIL-1beta ) from LPS primed MG6 cells , possibly due to lytic functions . Positive_regulation SFTPC TGM2 21840417 2505628 [SPC] *induces* the expression of in a time- and dose dependent manner . Positive_regulation SGCG TNF 18436821 1900356 Neutrophil elastase and , present in higher amounts in the tears of patients with dry eye , may *cause* [MAM] release , allowing rose bengal staining . Positive_regulation SGK1 EPHB2 16553792 1538049 directly phosphorylates SGK at Ser78 and indirectly *activates* [SGK] at Thr256 and Ser422 through unknown intermediate molecules . Positive_regulation SGK1 IL1B 19136575 2037704 [SGK] was *increased* by and late during gestation ( GD68 ) , while Nedd4-2 was decreased by IL-1beta and late during gestation . Positive_regulation SGOL1 STK39 18083840 1837137 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation SGOL2 STK39 18083840 1837272 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation SH2D1A FAS 21109225 2355398 Germline mutations in FASL and FAS impair *dependent* apoptosis and cause recessively or dominantly inherited autoimmune [lymphoproliferative syndrome] ( ALPS ) . Positive_regulation SH2D1A FAS 21696498 2446717 Defective function *causes* the autoimmune [lymphoproliferative syndrome] , but is also involved in common autoimmune disorders . Positive_regulation SH3D19 EMP1 10481948 643749 These observations strongly infer that peptide . [EBP] dimerization were *induced* by , and EMP37 but not by EMP13 , EMP26 or FMRF . Positive_regulation SH3D19 IL1B 18438857 1915465 Binding of [c/EBP] to this site was *regulated* by TNFalpha but not , resulting in down-regulation of cd-rap expression . Positive_regulation SH3D19 TNF 18438857 1915464 Binding of [c/EBP] to this site was *regulated* by but not IL-1beta , resulting in down-regulation of cd-rap expression . Positive_regulation SHBG HES2 10703679 672767 When comparing SBP at the end of the dialysis session ( t = end ) with that at the time of infusion ( t = iv ) , [SBP] decreased with saline , increased with albumin , and *increased* significantly with . Positive_regulation SHC1 EDN2 7929159 274306 *induces* tyrosine phosphorylation and GRB2 association of [Shc] in astrocytes . Positive_regulation SHC1 EPHB2 11509615 848597 Using IL-2R mutants and specific pharmacologic inhibitors , we found that the PI3K , but not , pathway is *required* for maximal induction of c-myc , cyclin D2 , cyclin D3 , cyclin E , and bcl-x ( L ) by [Shc] . Positive_regulation SHC1 EPHB2 9710602 526843 The arsenite induced tyrosine phosphorylation of Shc , enhancement of [Shc] and Grb2 interactions , and *activation* of were all drastically reduced by treatment of cells with either the general growth factor receptor poison suramin or the EGFR-selective inhibitor tyrphostin AG1478 . Positive_regulation SHC1 F2R 20559570 2279997 activation *induces* Etk/Bmx and [Shc] binding to the receptor C-tail to form a complex . Positive_regulation SHC1 HBEGF 15143154 1273155 Consistent with its agonist action , stimulation of these cells *caused* marked phosphorylation of the EGF-R and its adapter molecule , [Shc] , as well as ERK1/2 and its dependent protein , p90 ribosomal S6 kinase , in a manner similar to that elicited by Ang II or EGF . Positive_regulation SHC1 HBEGF 16336626 1503720 Phe induced phosphorylation of the EGF-R , and subsequently of [Shc] and ERK1/2 , was *attenuated* by inhibition of MMP or with the selective inhibitor , CRM197 , or by a neutralizing antibody . Positive_regulation SHC1 MAP2K6 16699171 1584296 In cardiomyocytes , thrombin triggers *dependent* [p66Shc-Ser] ( 36 ) phosphorylation , but this is not via EGFR transactivation ( or associated with Shc-Tyr ( 239 ) /Tyr ( 240 ) and/or Tyr ( 317 ) phosphorylation ) . Positive_regulation SHC1 MMP28 16336626 1503719 Phe induced phosphorylation of the EGF-R , and subsequently of [Shc] and ERK1/2 , was *attenuated* by inhibition of or HB-EGF with the selective inhibitor , CRM197 , or by a neutralizing antibody . Positive_regulation SHC1 MMP7 16336626 1503735 Phe induced phosphorylation of the EGF-R , and subsequently of [Shc] and ERK1/2 , was *attenuated* by inhibition of or HB-EGF with the selective inhibitor , CRM197 , or by a neutralizing antibody . Positive_regulation SHH ANGPT1 20098680 2201893 In vitro co-culture and matrigel plug assays demonstrated that PDAC cell derived [Shh] *induced* and IGF-1 production in BMPCs , resulting in their enhanced migration and capillary morphogenesis activity . Positive_regulation SHH CDKN1C 15891769 1411552 Here , we show that [Sonic hedgehog (Shh)] signalling has the opposite effect in the zebrafish retina , where it leads to cell-cycle exit , and that this is *mediated* by transcriptional activation of the cyclin kinase inhibitor . Positive_regulation SHH EPHB2 17385725 1727719 We examined early signaling events in the CB/CMZ and found that FGF2 or [Shh] *induced* a robust phosphorylation during the early stages of retina regeneration . Positive_regulation SHH EPHB2 20451654 2288388 *Activation* of by [sonic hedgehog] independent of canonical hedgehog signalling . Positive_regulation SHH FOXA1 15668254 1388277 and Foxa2 *regulated* [Shh] ( sonic hedgehog ) and Shh dependent genes in the respiratory epithelial cells that influenced the expression of genes in the pulmonary mesenchyme that are required for branching morphogenesis . Positive_regulation SHH FOXA1 19916800 2306995 To further understand how FoxA1 mediates neural differentiation , we have overexpressed FoxA1 through an adenovirus vector in P19 cells and identified that early neurogenesis related [sonic hedgehog (Shh)] gene is *activated* directly by . Positive_regulation SHH FOXA1 21093585 2383162 and Foxa2 positively and negatively *regulate* [Shh] signalling to specify ventral midbrain progenitor identity . Positive_regulation SHH HSD11B2 19765385 2140718 [Shh] *acts* through the induction of the enzyme <11betaHSD2> , which inactivates the GCs corticosterone and prednisolone , but not dexamethasone . Positive_regulation SHH MSX1 12163415 972373 We found that Msx1 expression was restricted to the anterior of the first upper molar site in the palatal mesenchyme and that was *required* for the expression of Bmp4 and Bmp2 in the mesenchyme and [Shh] in the medial edge epithelium ( MEE ) in the same region of developing palate . Positive_regulation SHH MSX1 21465616 2417514 With this strategy , we demonstrate that mesenchymal expression of and Msx2 is *required* for proper [Shh] and Bmp4 signaling to specify digit number and identity . Positive_regulation SHH MUC16 19104239 2018760 In vitro , [Shh] enhances gastric acid secretion and *induces* expression . Positive_regulation SHH TLR7 18277459 1872165 In the skin , strategies to inhibit angiogenesis signaling pathways include blockade of COX-2 , m-TOR , [sonic hedgehog] , growth factor receptor activation , and *activation* of . Positive_regulation SHH TMEM100 10475061 642425 [Sonic Hedgehog/Patched] signaling *involves* another , Smoothened , and its intracellular effectors , including the proto-oncogene GLI1 . Positive_regulation SHH TMEM156 10475061 642443 [Sonic Hedgehog/Patched] signaling *involves* another , Smoothened , and its intracellular effectors , including the proto-oncogene GLI1 . Positive_regulation SHH TMEM211 10475061 642523 [Sonic Hedgehog/Patched] signaling *involves* another , Smoothened , and its intracellular effectors , including the proto-oncogene GLI1 . Positive_regulation SHH TMEM213 10475061 642460 [Sonic Hedgehog/Patched] signaling *involves* another , Smoothened , and its intracellular effectors , including the proto-oncogene GLI1 . Positive_regulation SHH TNF 18772349 2012043 Further , NF-kappaB activation by or p65 overexpression *stimulates* [Shh] promoter activity and p65 binds to Shh promoter in vivo . Positive_regulation SHH TP63 17050669 1636130 In particular , and p63beta ( both TA and DeltaN isoforms ) and TAp73beta isoform *induce* [Shh] . Positive_regulation SHH WIF1 21652676 2470760 Additional signaling pathways are dysregulated in this model , primarily activated [Sonic Hedgehog] signaling in stem cells as a *result* of induced osteoblastic expression of Sonic Hedgehog . Positive_regulation SHH WNT7A 9025066 405817 Exogenous FGF-4 causes ectopic expression and *induces* ectopic [Shh] . Positive_regulation SHH ZIC2 23678105 2785440 Analyses of the molecular and cellular consequences of introducing Shh into the developing VTC and Zic2 and Boc into the central retina indicate that Boc expression alone is insufficient to fully activate the ipsilateral program and that *regulates* [Shh] expression . Positive_regulation SIAH1 SNCAIP 19224863 2061658 We found that robustly *increases* the steady-state levels of [SIAH] by decreasing its auto-ubiquitylation and degradation . Positive_regulation SIAH2 SNCAIP 19224863 2061659 We found that robustly *increases* the steady-state levels of [SIAH] by decreasing its auto-ubiquitylation and degradation . Positive_regulation SIAH3 SNCAIP 19224863 2061660 We found that robustly *increases* the steady-state levels of [SIAH] by decreasing its auto-ubiquitylation and degradation . Positive_regulation SIGLEC1 TLR7 17328080 1711921 Moreover , *induction* of surface [Siglec-1] was shown to be type I IFN dependent . Positive_regulation SIGLEC1 TNF 18414664 1894270 In cultured CD14 ( + ) monocytes isolated from healthy individuals , [sialoadhesin] expression was *induced* by interferon-alpha and interferon-gamma but not . Positive_regulation SIGLEC7 TNF 23029261 2680817 Here , we demonstrate that cross linking of [Siglec-7] by a specific monoclonal antibody ( mAb ) *induces* a remarkably high production of IL-6 , IL-1a , CCL4/MIP-1ß , IL-8 and . Positive_regulation SIGLEC9 FAS 15827126 1439471 Inflammatory neutrophils obtained from patients with acute septic shock or rheumatoid arthritis demonstrated increased [Siglec-9] , but normal receptor *mediated* cytotoxic responses when compared with normal blood neutrophils . Positive_regulation SIL1 MMP28 12794843 1098375 To characterize the clinical and histopathologic changes in a rat model of broad-spectrum *induced* [musculoskeletal syndrome (MSS)] , and to facilitate research into the causes and treatments of MSS in humans . Positive_regulation SIL1 MMP7 12794843 1098390 To characterize the clinical and histopathologic changes in a rat model of broad-spectrum *induced* [musculoskeletal syndrome (MSS)] , and to facilitate research into the causes and treatments of MSS in humans . Positive_regulation SIL1 TNF 23446805 2749248 In addition , [BaP] *induced* the release of interleukin (IL)-1ß and from these cells . Positive_regulation SIN3A CAPN8 17986223 1850758 Interestingly , [SAP] did not *induce* caspase and activation , suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways . Positive_regulation SIN3A TNF 10788429 688665 Acute phorbol 12-myristate 13-acetate pretreatment also inhibited *stimulated* [SAP] kinase activity , while chronic pretreatment reversed the effects of UTP . Positive_regulation SIRPA IL1B 12483539 1024822 Moreover , *induced* association of [SHPS-1] with IL-1RAcP , a second subunit of IL-1 receptor , whereas expression of SHPS-1 mutant that lack SHP-2 binding function clearly blocked the association and tyrosine phosphorylation of endogenous SHPS-1 . Positive_regulation SIRT1 EPHB2 21697093 2465468 Subsequently , and p38 kinase activated by SIRT1 also *induce* [SIRT1] activation , forming a positive feedback loop to sustain downstream signaling of these kinases . Positive_regulation SIRT1 FOXO1 18849969 1988619 In view of the reciprocal *activation* of and its coactivator peroxisome proliferator activated receptor-gamma coactivator-1alpha ( PGC-1alpha , encoded by Ppargc1a ) by [SIRT1] activators , our results illustrate how the exchange of two gluconeogenic regulators during fasting maintains energy balance . Positive_regulation SIRT1 FOXO1 20181797 2242787 Instead , Dx *increased* the association of [sirtuin-1] with , thereby causing a decrease in FoxO acetylation . Positive_regulation SIRT1 FOXO1 21149440 2384737 Luciferase promoter assays demonstrate that directly *activates* [SIRT1] promoter activity and that both the IRS-1 and FKHD-L enable FoxO1 dependent SIRT1 transcription . Positive_regulation SIRT1 FOXO1 21149440 2384739 Consistently , overexpression *increases* [SIRT1] expression , and FoxO1 depletion by siRNA reduces SIRT1 expression at both the messenger RNA and protein levels in vascular smooth muscle cells and HEK293 cells . Positive_regulation SIRT1 FOXO1 21149440 2384740 Moreover , resveratrol , a plant polyphenol activator of SIRT1 , increases *dependent* [SIRT1] transcription activity and thus induces its expression . Positive_regulation SIRT1 FOXO1 21149440 2384741 These findings suggest that positive feedback mechanisms regulate *dependent* [SIRT1] transcription and indicate a previously unappreciated function for FoxO1 . Positive_regulation SIRT1 FOXO1 22956852 2667699 In Caenorhabditis elegans , [sir-2.1/SIRT1] overexpression protects neurons from the early phases of expanded polyglutamine ( polyQ ) toxicity , and this protection *requires* the longevity promoting factor . Positive_regulation SIRT1 FOXO1 24773342 2944470 In that study , central inhibition of [Sirt1] decreased body weight and food intake as a *result* of a mediated increase in the anorexigenic proopiomelanocortin (POMC) and decrease in the orexigenic Agouti related peptide in the hypothalamic arcuate nucleus . Positive_regulation SIRT1 PGC 20929977 2368928 Parallel to this , we observed AMPK activation , deacetylation , and [SIRT1] *induction* in trained wild-type mice . Positive_regulation SIRT1 PGC 21874557 2510392 Parallel to these changes , we observed AMPK activation , [SIRT1] *induction* and deacetylation . Positive_regulation SIRT1 PGC 22892143 2672013 We demonstrate that nitrite significantly increases cellular mitochondrial number by augmenting the activity of adenylate kinase , resulting in AMP kinase phosphorylation , downstream *activation* of [sirtuin-1] , and deacetylation of , the master regulator of mitochondrial biogenesis . Positive_regulation SIRT1 TNF 20617556 2286542 Involvement of the p65/RelA subunit of NF-kappaB in *induced* [SIRT1] expression in vascular smooth muscle cells . Positive_regulation SIRT1 TNF 20617556 2286557 Our study indicates that p65/RelA mediates the *induced* elevated expression of [SIRT1] in VSMCs , shedding new light on the regulation of SIRT1 under inflammatory conditions . Positive_regulation SIRT1 TNF 22069489 2504291 *Activation* of [Sirt1] by resveratrol inhibits induced inflammation in fibroblasts . Positive_regulation SIRT1 TNF 22125309 2562844 C2C12 myoblasts , a subclone of the C2 cell line produced for their differentiation potential and used to examine intrinsic ageing , unlike C2 cells , do not die in the *presence* of and do not upregulate [Sirt1] . Positive_regulation SIRT1 TNF 22683888 2626477 Stimulation of human mature SGBS adipocytes with *caused* similar changes in PPARß/d and [SIRT1] to those reported in obese patients . Positive_regulation SIRT1 TNF 23778143 2815370 [SIRT1] was upregulated through c-MYC in embryonic and postnatal Pkd1-mutant mouse renal epithelial cells and tissues and could be *induced* by , which is present in cyst fluid during cyst development . Positive_regulation SIRT3 PGC 21454513 2422182 Erra knockdown assays indicated that Erra is required for full induction of [Sirt3] gene expression in *response* to . Positive_regulation SIRT3 PGC 23166782 2700225 ERRa siRNA attenuated *mediated* induction of [SIRT3] , but did not affect constitutive expression . Positive_regulation SIRT5 PGC 24687991 2949248 Moreover , [SIRT5] levels are *regulated* by and AMPK , which have opposite effects on its expression.-Buler , M. , Aatsinki , S.-M. , Izzi , V. , Uusimaa , J. , Hakkola , J . SIRT5 is under the control of PGC-1a and AMPK and is involved in regulation of mitochondrial energy metabolism . Positive_regulation SKA1 STK39 18083840 1837167 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation SKA2 STK39 18083840 1837152 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation SKP1 EPHB2 11412047 828325 [SCF] *induced* a rapid and transient activation of and p38 in a dose dependent manner . Positive_regulation SKP1 EPHB2 16436136 1516420 The induction of RANTES by SCF or TNF-alpha was mediated by ERK and NF-kappaB , respectively , and [SCF] induced MIP-1beta release was *mediated* by . Positive_regulation SKP1 FAS 17695539 1782180 High expression of [c-kit/SCF] ( 2+ , 3+ ) was *detected* in 28/45 cases of EFT ( 62.2 % ) , whereas and IGF-IR were observed in 16/45 ( 37.7 % ) and 9/45 ( 20 % ) , respectively . Positive_regulation SKP1 IL1B 11934803 927862 5. Budesonide inhibited *induced* [SCF] mRNA expression ( -68 % ) at 2 .5 h and even more so at 10 h ( -192 % ) Positive_regulation SKP1 IL1B 15962114 1423088 Transfection experiments with the SCF promoter including intron1 also confirm this increase and decrease of SCF expression by IL-1beta and glucocorticoids , and the potentiation by glucocorticoids of the *induced* [SCF] expression . Positive_regulation SKP1 IL1B 16407046 1513292 We investigated whether HDSMCs are capable of expressing and releasing MCP-1 , IL-6 and [SCF] in *response* to IL-4 , IL-13 , and tumor necrosis factor-alpha . Positive_regulation SKP1 IL1B 16612597 1665857 The effect of exogenous IFNgamma on AML blast proliferation was dependent on the local cytokine network and IFNgamma ( 1 ) inhibited proliferation in the *presence* of exogenous , GM-CSF , G-CSF and [SCF] ; Positive_regulation SKP1 IL1B 7544739 318384 Stimulation with only modestly *increased* SCF mRNA levels , soluble [SCF] production at 24 hours , and membrane bound SCF . Positive_regulation SKP1 JAG1 10342559 616490 However , in the presence of [SCF] alone , *increased* erythroid colony formation twofold . Positive_regulation SKP1 TNF 10067879 594035 Activin , TGF beta , TGF alpha , and *had* no effect on [SCF] gene expression in vitro . Positive_regulation SKP1 TNF 16407046 1513291 We investigated whether HDSMCs are capable of expressing and releasing MCP-1 , IL-6 and [SCF] in *response* to IL-4 , IL-13 , IL-1beta and . Positive_regulation SKP1 TNF 16436136 1516374 Either [SCF] or TNF-alpha could *induce* release from HMC-1 cells of interleukin (IL)-8 , monocyte chemoattractant protein (MCP)-1 , regulated upon activation normal T-cell expressed and secreted ( RANTES ) , and I-309 , while SCF and induced release of macrophage inflammatory protein (MIP)-1beta and interferon-gamma-inducible protein-10 (IP-10) , respectively . Positive_regulation SKP1 TNF 18549896 1923752 In vitro studies using primary mouse hepatocytes show that [SCF] is *induced* by ; Positive_regulation SKP1 TNF 7544739 318387 Similarly , a sustained increase in soluble [SCF] production was *detected* during 1 to 5 days of hydrocortisone exposure ( 0.27 +/- 0.03 to 1.10 +/- 0.08 ng/mL per 10 ( 6 ) cells ) , while stimulation modestly increased the production of soluble SCF in 24-hour cultures only . Positive_regulation SKP1 TNF 9307079 454437 We have shown that the [SCF] expression can be induced in vitro by co-culture with mast cells and this induction was *dependent* on the release of . Positive_regulation SKP1 TNF 9637535 513870 [SCF] was constitutively produced from fibroblasts in its transmembrane form and could be *induced* by . Positive_regulation SKP1 TNF 9759885 536631 Coligation of SCFR augmented Fc epsilonRI mediated activation of MAP kinases , especially JNK activation , and SCF augmented Fc epsilonRI mediated TNF-alpha production in MC/9 cells , although [SCF] alone did not *induce* production . Positive_regulation SKP2 CCND1 16924241 1692230 Mutant B-RAF signaling and *regulate* [Cks1/S-phase kinase associated protein 2-mediated] degradation of p27Kip1 in human melanoma cells . Positive_regulation SKP2 IFI27 17372849 1791641 LXR agonists appear to cause G1 cell cycle arrest in cells by reducing expression of [Skp2] and *inducing* the accumulation of ( Kip ) . Positive_regulation SKP2 IFI27 19356250 2074501 Tax increases ( KIP1 ) protein stability by activating the anaphase promoting complex/cyclosome ( APC/C ) precociously , *causing* degradation of [Skp2] and inactivation of SCF ( Skp2 ) , the E3 ligase that targets p27 ( KIP1 ) . Positive_regulation SKP2 WIF1 19174556 2032535 , a Wnt pathway inhibitor , *regulates* [SKP2] and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells . Positive_regulation SLA FUT4 9303355 453984 increased [SLA] expression is *due* mainly to increased activity . Positive_regulation SLAMF1 IL1B 11489980 845559 [SLAM] surface expression is strongly *up-regulated* by . Positive_regulation SLC11A2 TNF 16221503 1517855 *regulates* the mRNA levels of HAMP , IREG1 , [DMT1] and TfR2 in cultured hepatocytes from both iron loaded and control animals . Positive_regulation SLC11A2 TNF 16224057 1483560 *caused* upregulation of TfR and [DMT1] and downregulation of FP1 , which were demonstrated in mRNA as well as protein levels . Positive_regulation SLC12A2 CLU 12904508 1119114 Our results suggest that NKCC1 functions in oligodendrocytes to maintain [ above electrochemical equilibrium and that [NKCC1] is *required* for GABAergic trophic effects . Positive_regulation SLC12A2 EPHB2 11909643 923744 Activation of [NKCC1] by hyperosmotic stress in human tracheal epithelial cells *involves* PKC-delta and . Positive_regulation SLC12A2 EPHB2 11909643 923746 The results indicate that hyperosmotic stress activates [NKCC1] and this activation is *regulated* by PKC-delta and . Positive_regulation SLC12A3 OSR1 20490538 2301175 WNK kinases phosphorylate and activate oxidative stress responsive kinase 1 ( OSR1 ) and STE20-like proline and alanine-rich kinase ( SPAK ) , and and SPAK phosphorylate and *activate* the thiazide-sensitive [Na-Cl cotransporter (NCC)] . Positive_regulation SLC12A3 OSR1 22949526 2672625 In both SpakT243A/+ and Osr1T185A/+ knock-in db/db mice , which carry mutations that disrupt the signal from WNK kinases , increased phosphorylation of NCC and elevated blood pressure were completely corrected , indicating that phosphorylation of SPAK and by WNK kinases is *required* for the increased activation and phosphorylation of [NCC] in this model . Positive_regulation SLC12A5 CAPN8 22895718 2647170 Taken together , these findings show that activation *leads* to cleavage of [KCC2] , thereby modulating GABAergic signaling . Positive_regulation SLC12A9 CCND1 10377442 623834 Silibinin induced G1 arrest was associated with a marked decrease in the kinase activity of cyclin dependent kinases (CDKs) and associated cyclins because of a highly significant decrease in , CDK4 , and CDK6 levels and an *induction* of [Cip1/p21] and Kip1/p27 followed by their increased binding with CDK2 . Positive_regulation SLC12A9 CCND1 21312237 2398661 WIN 55,212-2 also upregulated phospho-ERK1/2 , *induced* Kip1/p27 and [Cip1/WAF1/p21] expression , decreased and cyclin E expression , decreased Cdk 2 , Cdk 4 , and Cdk 6 expression levels , and decreased phospho-Rb and E2F-1 expression . Positive_regulation SLC12A9 CCND1 21575346 2430308 At the saccular stage , the expression of decreased significantly and the [p21CIP1] expression *increased* significantly . Positive_regulation SLC12A9 CCND1 9236224 445602 We have shown previously ( ) that NGF *induces* the expression of the p21 [WAF1/CIP1/Sdi1] ( p21 ) cyclin dependent kinase (Cdk) inhibitor protein and the G1 phase cyclin , . Positive_regulation SLC12A9 EPHB2 17941827 1849404 Heregulin beta1 promotes breast cancer cell proliferation through *dependent* induction of cyclin D1 and [p21Cip1] . Positive_regulation SLC12A9 EPHB2 19492998 2091374 The NFkB dependent drop in cyclin D1 , along with the dependent *induction* of p21 [Cip1/Kip1] , is responsible for growth arrest . Positive_regulation SLC12A9 EPHB2 20855497 2325846 In nonpolarized epithelial cells , activation *results* in oncogenic stress , up-regulation of the p21 ( [Waf1/Cip1] ) cyclin dependent kinase inhibitor , and induction of senescence . Positive_regulation SLC12A9 FAS 14767544 1207630 In SK-Br3 cells , cerulenin induced inhibition of activity *resulted* in down-regulation of p53 , and up-regulation of cyclin dependent kinase inhibitor (CDKi) [p21WAF1/CIP1] . Positive_regulation SLC12A9 IFI27 10530763 654511 Moreover , mimosine *induced* [p21CIP1] expression in H226 and H358 cells , while it activated expression in H322 cells . Positive_regulation SLC12A9 KLF9 10749849 698403 The gut enriched ( Kruppel-like factor 4 ) *mediates* the transactivating effect of p53 on the [p21WAF1/Cip1] promoter . Positive_regulation SLC12A9 TNF 10644980 661655 *Induction* of [p21Waf1/Cip1] by requires NF-kappaB activity and antagonizes apoptosis in Ewing tumor cells . Positive_regulation SLC12A9 TNF 7629160 316644 also *increased* the expression level of [Cip1] ( p21 ) protein in a dose dependent manner . Positive_regulation SLC12A9 TNF 7629160 316649 Taken together these results suggest that Rb , p53 , and [Cip1] ( p21 ) proteins mediate TNF-alpha antimitogenic activity , and *induces* growth arrest in the G1 phase in MCF-7 cells . Positive_regulation SLC12A9 TNF 9588176 504631 Prevention of *mediated* induction of [p21WAF1/CIP1] sensitizes MCF-7 carcinoma cells to TNF induced apoptosis . Positive_regulation SLC15A1 TNF 16328452 1539487 and IFN-gamma *increased* the activity , and total and apical membrane protein expression of [PepT1] protein in a concentration- and time dependent fashion . Positive_regulation SLC15A1 TNF 16328452 1539489 Whereas neither nor IFN-gamma *increased* [PepT1] mRNA expression in any segment of the intestine , treatment with IL-1beta increased PepT1 mRNA expression in mouse proximal and distal colon and decreased PepT1 mRNA expression in jejunum and ileum . Positive_regulation SLC15A2 JAK2 23711493 2792827 The present study thus explored whether *contributes* to the regulation of PEPT1 and [PEPT2] activity . Positive_regulation SLC15A2 SGK1 19088452 2003730 Dynasore experiments demonstrated that and NHERF2 *activate* [PEPT2] by stabilizing the transporter at the cell surface . Positive_regulation SLC15A2 SGK1 19672619 2150718 According to recent in vitro experiments , the peptide transporter [PepT2] is *stimulated* by the serum- and glucocorticoid-inducible kinase . Positive_regulation SLC15A2 SLC9A3R2 19088452 2003731 Dynasore experiments demonstrated that SGK1 and *activate* [PEPT2] by stabilizing the transporter at the cell surface . Positive_regulation SLC16A1 SLC16A3 15997097 1430263 We conclude that [MCT1] is responsible for L-lactic acid uptake and L-lactic acid efflux is *mediated* by in RD cells . Positive_regulation SLC16A3 BSG 24970254 2952461 is *required* for the expression of MCT1 and [MCT4] in the corneal endothelium . Positive_regulation SLC16A3 DNM1 23033272 2702578 Furthermore , inhibition of *resulted* in enhanced expression of hypermethylated genes ( Bcl3 and [Slc16a3] ) in the decidual bed as compared with control , indicating aberration of gene expression may be associated with DNM-inhibition induced decidual perturbation . Positive_regulation SLC16A3 PRKAA1 17909267 1803617 As for the *role* of in the regulation of the monocarboxylate transporters 1 and 4 ( MCT1 and [MCT4] ) , it has been observed that AICAR treatment decreased MCT1 and increased MCT4 mRNA levels . Positive_regulation SLC16A3 PRKAA1 23886299 2854593 These results suggest that acute exercise induced increases in MCT1 and [MCT4] mRNA expression may be possibly *mediated* by activation , at least in part in fast-twitch muscle . Positive_regulation SLC16A3 PRKAA2 17909267 1803618 As for the *role* of in the regulation of the monocarboxylate transporters 1 and 4 ( MCT1 and [MCT4] ) , it has been observed that AICAR treatment decreased MCT1 and increased MCT4 mRNA levels . Positive_regulation SLC16A3 PRKAA2 23886299 2854594 These results suggest that acute exercise induced increases in MCT1 and [MCT4] mRNA expression may be possibly *mediated* by activation , at least in part in fast-twitch muscle . Positive_regulation SLC16A3 PRKAB1 17909267 1803619 As for the *role* of in the regulation of the monocarboxylate transporters 1 and 4 ( MCT1 and [MCT4] ) , it has been observed that AICAR treatment decreased MCT1 and increased MCT4 mRNA levels . Positive_regulation SLC16A3 PRKAB1 23886299 2854595 These results suggest that acute exercise induced increases in MCT1 and [MCT4] mRNA expression may be possibly *mediated* by activation , at least in part in fast-twitch muscle . Positive_regulation SLC16A3 PRKAB2 17909267 1803620 As for the *role* of in the regulation of the monocarboxylate transporters 1 and 4 ( MCT1 and [MCT4] ) , it has been observed that AICAR treatment decreased MCT1 and increased MCT4 mRNA levels . Positive_regulation SLC16A3 PRKAB2 23886299 2854596 These results suggest that acute exercise induced increases in MCT1 and [MCT4] mRNA expression may be possibly *mediated* by activation , at least in part in fast-twitch muscle . Positive_regulation SLC16A3 PRKAG1 17909267 1803621 As for the *role* of in the regulation of the monocarboxylate transporters 1 and 4 ( MCT1 and [MCT4] ) , it has been observed that AICAR treatment decreased MCT1 and increased MCT4 mRNA levels . Positive_regulation SLC16A3 PRKAG1 23886299 2854597 These results suggest that acute exercise induced increases in MCT1 and [MCT4] mRNA expression may be possibly *mediated* by activation , at least in part in fast-twitch muscle . Positive_regulation SLC16A3 PRKAG2 17909267 1803622 As for the *role* of in the regulation of the monocarboxylate transporters 1 and 4 ( MCT1 and [MCT4] ) , it has been observed that AICAR treatment decreased MCT1 and increased MCT4 mRNA levels . Positive_regulation SLC16A3 PRKAG2 23886299 2854598 These results suggest that acute exercise induced increases in MCT1 and [MCT4] mRNA expression may be possibly *mediated* by activation , at least in part in fast-twitch muscle . Positive_regulation SLC16A3 SLC16A1 15997097 1430264 We conclude that is responsible for L-lactic acid uptake and L-lactic acid efflux is *mediated* by [MCT4] in RD cells . Positive_regulation SLC16A7 SLC16A3 23356841 2738593 In particular , [MCT2] expression was *detected* in RCECs , whereas MCT1 , and MCT5 expression was detected in the surface layer . Positive_regulation SLC17A5 ARSA 23040521 2689799 Administering higher doses of arginine in subjects with *results* in increases in [AST] and ALT levels , especially in the subset of patients with elevated baseline aminotransferases . Positive_regulation SLC17A5 SYNM 23485615 2771904 CK significantly inhibited *induced* increases in serum alanine aminotransferase ( ALT ) and [aspartate aminotransferase (AST)] activities , fibrosis score , and hepatic malondialdehyde and collagen content . Positive_regulation SLC17A5 TNF 12472776 1032585 I/R injury was characterized by significant tissue hemorrhage with increased microvascular permeability , elevated renal tissue levels of and myeloperoxidase (MPO) , *increased* serum levels of creatinine and [aspartate aminotransferase (AST)] and hematuria . Positive_regulation SLC17A5 TNF 20620476 2286604 Serum [AST] , ALT , and LDH levels were significantly *increased* by IR ( 4- , 5.6- , and 7.0-fold , respectively ) , with significant changes in liver histology , protein carbonyl/GSH ratio ( 481 % enhancement ) , and serum ( 6.1-fold increase ) . Positive_regulation SLC1A1 RARB 19450544 2120303 We conclude that in C6 glioma cells the induction of [Slc1a1] by ATRA *requires* the synthesis of , suggesting that the receptor is involved in the regulation of the transporter gene . Positive_regulation SLC1A1 TNF 14960606 1208565 however , only [EAAT3] upregulation was *mediated* by increased . Positive_regulation SLC1A2 TNF 15660126 1369508 Herein , we demonstrate that both mediated repression and EGF mediated *activation* of [EAAT2] expression require NF-kappaB . Positive_regulation SLC1A6 GRIN3A 19331175 2052708 In addition , , mGluR6 , mGluR8 and EAAT4 mRNA were differentially expressed in PC-3 and LNCaP cells , mGluR7 and [EAAT4] mRNA expression was *induced* and mGluR8 was silenced by dihydrotestosterone ( DHT ) treatment in LNCaP cells . Positive_regulation SLC1A6 GRM8 19331175 2052709 In addition , NR3A , mGluR6 , and EAAT4 mRNA were differentially expressed in PC-3 and LNCaP cells , mGluR7 and [EAAT4] mRNA expression was *induced* and mGluR8 was silenced by dihydrotestosterone ( DHT ) treatment in LNCaP cells . Positive_regulation SLC1A6 PIK3CA 18226120 1864179 These results demonstrate that acute ethanol exposure increases [EAAT4] activity at clinically relevant concentrations and that PKC and may *mediate* this . Positive_regulation SLC1A6 PIK3R1 18226120 1864180 These results demonstrate that acute ethanol exposure increases [EAAT4] activity at clinically relevant concentrations and that PKC and may *mediate* this . Positive_regulation SLC1A6 SPTBN2 16429157 1516061 Cell culture studies demonstrate that wild-type but not mutant *stabilizes* [EAAT4] at the plasma membrane . Positive_regulation SLC22A12 PDZK1 15304510 1322346 The multivalent PDZ domain containing protein *regulates* transport activity of renal urate-anion exchanger [URAT1] via its C terminus . Positive_regulation SLC22A3 AXIN2 17072303 1649867 *regulates* [EMT] by acting as a nucleocytoplasmic chaperone for GSK3beta , the dominant kinase responsible for controlling Snail1 protein turnover and activity . Positive_regulation SLC22A3 CD14 24064911 2857695 This study demonstrated that *promoted* tumor cell [EMT] and invasion through TNF-a , whereas knockdown of CD14 expression inhibited gastric cancer cell invasion and EMT . Positive_regulation SLC22A3 CEACAM6 23857344 2817066 Elevated levels of in pancreatic cancer cells *promoted* [EMT] , migration and invasion in vitro and metastasis in animal models , whereas shRNA mediated CEACAM6 knockdown had the opposite effect . Positive_regulation SLC22A3 CTGF 16613711 1550902 Exogenous can *mediate* the [EMT] but has no collagen-synthesis effects on HK2 cells . Positive_regulation SLC22A3 CTGF 16867255 1592898 Our data provides further evidence that might be *involved* in Ang II-induced [EMT] in PTC . Positive_regulation SLC22A3 CTGF 17161611 1663714 This study was carried out to further characterize a synthetic hexadeca-peptide ( P2 ) homologous to this domain and to determine its effect on mediated solid phase cell adhesion , [EMT] *induction* and fibrogenesis in rat renal NRK-52E cells . Positive_regulation SLC22A3 CTGF 17951996 1844519 In this study , we investigated the role of integrin linked kinase (ILK) in mediating *induced* [EMT] . Positive_regulation SLC22A3 CTGF 21530658 2449138 In vitro , Adanti-ERK2 gene therapy inhibited *induced* tubular [EMT] and attenuated the cell motility function induced by CTGF . Positive_regulation SLC22A3 CTGF 23073116 2716925 We demonstrated that *induced* [EMT] of mesothelial cells in a dose- and time dependent manner . Positive_regulation SLC22A3 CTGF 23073116 2716927 These findings suggest that is not only an important mediator but a potent *activator* of [EMT] in peritoneal mesothelial cells , which in turn promotes gastric cancer cell adhesion to peritoneum . Positive_regulation SLC22A3 CTGF 24703458 2938774 Then , the *induced* [EMT] in this cell line was determined , to further determine the association of RFP fluorescence intensity with the CTGF expression or CTGF induced EMT . Positive_regulation SLC22A3 CTGF 24703458 2938775 The constructed HK-C2AR cells could stably express RFP and CTGF proportionally , and the expressed in the cell line could *induce* [EMT] of cells , whereas the RFP expressed in the cell could exhibit bright red fluorescence after excitation . Positive_regulation SLC22A3 CTGF 24703458 2938779 After the silence in CTGF , the RFP expression was also decreased , and the *induced* [EMT] was also inhibited . Positive_regulation SLC22A3 CTGF 24703458 2938780 Also , this cell line could be used to quantitatively determine the mechanism of *induced* [EMT] in renal tubular epithelial cells . Positive_regulation SLC22A3 EPHB2 15548370 1338396 However , the *role* of in the induction of TGF-beta1 mediated [EMT] remains unclear . Positive_regulation SLC22A3 EPHB2 15677311 1376089 Chemical inhibition of but not p38 MAPK inhibited TGF-beta1 induced Smad 2 phosphorylation , and both MAPK inhibitors *inhibited* TGF-beta1- and H ( 2 ) O ( 2 ) -induced [EMT] . Positive_regulation SLC22A3 EPHB2 17267741 1704188 These findings support important profibrotic roles for plasmin that include PAR-1 dependent signaling and [EMT] *induction* . Positive_regulation SLC22A3 EPHB2 17881458 1818601 Oncostatin M-induced effects on [EMT] in human proximal tubular cells : differential *role* of signaling . Positive_regulation SLC22A3 EPHB2 19056678 2029846 Activation of or p38 is *required* for both TGF-beta induced [EMT] and cell migration , whereas PI3K/Akt is necessary only for TGF-beta promoted cell migration but not for EMT . Positive_regulation SLC22A3 EPHB2 21792635 2584891 Inhibiting p38 and signalling *had* no effect on [EMT] . Positive_regulation SLC22A3 EPHB2 23160379 2848513 In line with these findings , inhibition of either c-Abl or clearly *attenuated* CLDN1 induced [EMT] , as evidenced by a reversal of N-cadherin and E-cadherin expression patterns , and restored normal motility . Positive_regulation SLC22A3 F2R 17267741 1704189 These findings support important profibrotic roles for plasmin that include *dependent* ERK signaling and [EMT] induction . Positive_regulation SLC22A3 FAS 22508480 2744711 However , this pathway has also been shown to promote tumor cell motility , leading to the hypothesis that signaling may *induce* [epithelial-mesenchymal transition (EMT)] to promote metastasis . Positive_regulation SLC22A3 FAS 22508480 2744714 The ERK1/2 pathway was activated by signaling and is *required* for FasL induced [EMT] and motility . Positive_regulation SLC22A3 FAS 22508480 2744717 Altogether , these data indicate that signaling may *induce* [EMT] to promote tumor motility and metastasis in GI cancer in vivo and in vitro . Positive_regulation SLC22A3 FAS 23582741 2804359 Collectively , these data indicate that GSK-3ß regulates Snail and ß-catenin expression during *induced* [EMT] in gastrointestinal cancer . Positive_regulation SLC22A3 FAS 23929433 2887830 miR-23a inhibits E-cadherin expression and is regulated by AP-1 and NFAT4 complex during *induced* [EMT] in gastrointestinal cancer . Positive_regulation SLC22A3 FOXQ1 21285253 2393078 Ectopic expression of increased cell migration and invasion in vitro , enhanced the lung metastatic capabilities of mammary epithelial cells in vivo , and *triggered* a marked [EMT] . Positive_regulation SLC22A3 FOXQ1 21346143 2415468 In this study , we defined a critical functional *role* for the Forkhead transcription factor in regulating [EMT] in breast cancer cells . Positive_regulation SLC22A3 FOXQ1 21346143 2415470 Mechanistic investigations revealed that *induced* [EMT] was associated with transcriptional inactivation of the epithelial regulator E-cadherin ( CDH1 ) . Positive_regulation SLC22A3 FOXQ1 21346143 2415471 Our findings define a key *role* for in regulating [EMT] and aggressiveness in human cancer . Positive_regulation SLC22A3 FOXQ1 23403865 2748688 In this study , we defined a pivotal functional *role* for the Forkhead transcription factor in regulating [EMT] in bladder cancer . Positive_regulation SLC22A3 FOXQ1 24005989 2916086 *induced* [epithelial-mesenchymal transition (EMT)] through the transactivation of ZEB2 expression by directly binding to the ZEB2 promoter . Positive_regulation SLC22A3 IL1B 18792103 1986427 or TNF-alpha alone can also *augment* TGF-beta1 induced [EMT] . Positive_regulation SLC22A3 JAG1 14976548 1213144 TGF-beta induced [EMT] was *blocked* by RNA silencing of HEY1 or , and by chemical inactivation of Notch . Positive_regulation SLC22A3 JAG1 14976548 1213149 Our findings identify a new mechanism for functional integration of Jagged1/Notch signalling and coordinated activation of the Hey1 transcriptional repressor controlled by TGF-beta/Smad3 , and demonstrate functional *roles* for Smad3 , Hey1 , and in mediating TGF-beta induced [EMT] . Positive_regulation SLC22A3 JAG1 20010940 2191375 Epithelial-to-mesenchymal transition is mediated , in part , by two transcription repressors , Snail and Slug , that are known to be targets of the Notch signaling pathway , and induced Notch activation *increases* [EMT] . Positive_regulation SLC22A3 JAG1 23560082 2767578 To further address how these pathways coordinate in the process , we specifically disrupted Notch1 or Jagged1 in the endocardium of mouse embryonic hearts and showed that signaling in the endocardium is *essential* for [EMT] and early valvular cushion formation . Positive_regulation SLC22A3 MAOA 24865426 2945508 Knockdown and overexpression of MAOA in human PCa cell lines indicated that *induces* [EMT] through activation of VEGF and its coreceptor neuropilin-1 . Positive_regulation SLC22A3 MMP28 16940349 1609374 Current results indicate that can *induce* [EMT] and cell invasion through a TGF-beta dependent mechanism suggesting novel biological roles for this enzyme in the regulation of epithelial cell function and in the induction of carcinogenesis . Positive_regulation SLC22A3 MMP28 18286378 1931855 recent investigations have shown how delineation of the extracellular targets and intracellular signaling pathways by which action on cancer cells can *induce* [EMT] provides insight into novel therapeutic targets . Positive_regulation SLC22A3 MMP28 20075196 2218644 AMCM induced tubular cell [EMT] in C1.1 cells was *inhibited* by broad-spectrum inhibitor ( GM6001 ) , MMP-2/9 inhibitor , and in AMCM after MMP-9 removal by monoclonal Ab against MMP-9 . Positive_regulation SLC22A3 MMP28 22786680 2627932 Here , we identify a critical mediator of lung cancer progression , Rac1b , a tumor associated protein with cell transforming properties that are linked to the *induced* [epithelial-mesenchymal transition (EMT)] in lung epithelial cells . Positive_regulation SLC22A3 MMP28 22786680 2627954 We show that expression of mouse Rac1b in lung epithelial cells of transgenic mice stimulated EMT and spontaneous tumor development and that *activation* of [EMT] by induced expression of Rac1b gave rise to lung adenocarcinoma in the transgenic mice through bypassing oncogene induced senescence . Positive_regulation SLC22A3 MMP7 18286378 1931870 recent investigations have shown how delineation of the extracellular targets and intracellular signaling pathways by which action on cancer cells can *induce* [EMT] provides insight into novel therapeutic targets . Positive_regulation SLC22A3 MMP7 20075196 2218659 AMCM induced tubular cell [EMT] in C1.1 cells was *inhibited* by broad-spectrum inhibitor ( GM6001 ) , MMP-2/9 inhibitor , and in AMCM after MMP-9 removal by monoclonal Ab against MMP-9 . Positive_regulation SLC22A3 MMP7 22786680 2627947 Here , we identify a critical mediator of lung cancer progression , Rac1b , a tumor associated protein with cell transforming properties that are linked to the *induced* [epithelial-mesenchymal transition (EMT)] in lung epithelial cells . Positive_regulation SLC22A3 MMP7 22786680 2627969 We show that expression of mouse Rac1b in lung epithelial cells of transgenic mice stimulated EMT and spontaneous tumor development and that *activation* of [EMT] by induced expression of Rac1b gave rise to lung adenocarcinoma in the transgenic mice through bypassing oncogene induced senescence . Positive_regulation SLC22A3 MUC16 21326240 2403907 The *role* of in [EMT] was investigated using single-chain antibody mediated knockdown of cell surface CA125/MUC16 in overexpressing EOC NIH : OVCAR3 cells . Positive_regulation SLC22A3 NEDD9 21829474 2468028 In this study , we wished to discern the role of NEDD9 in breast cancer progression and to investigate the molecular mechanism by which *regulates* [EMT] and promotes invasion in triple negative breast cancer . Positive_regulation SLC22A3 NEDD9 21829474 2468030 Data presented in this report contribute to the understanding of the mechanisms by which *promotes* [EMT] , and provide useful clues to the evaluation of the potential of NEDD9 as a responsive molecular target for TNBC chemotherapy . Positive_regulation SLC22A3 NEDD9 24728978 2935860 While NEDD9 plays a crucial role in epithelial-mesenchymal transition (EMT) , the functional mechanism underlying *mediated* [EMT] in prostate cancer ( PCa ) remains uncertain . Positive_regulation SLC22A3 PGC 22608985 2614531 RNAi mediated suppression of PGC-1a induced MtD and EMT , whereas overexpression of prevented Aldo induced MtD and *inhibited* [EMT] . Positive_regulation SLC22A3 PIGR 22025622 2508038 Furthermore , high expression of was *sufficient* to induce [EMT] through activation of Smad signaling . Positive_regulation SLC22A3 PLAU 21181094 2385799 Downregulation of *inhibits* intermittent hypoxia induced [epithelial-mesenchymal transition (EMT)] in DAOY and D283 medulloblastoma cells . Positive_regulation SLC22A3 PLAU 24195704 2883017 In a recent study published in Respiratory Research , Qin Wang and colleagues investigated the *role* of receptor ( uPAR ) in [EMT] in small airway epithelium of COPD patients . Positive_regulation SLC22A3 TGM2 23290789 2764009 These results suggested that *induces* N-cadherin expression of TGF-ß1 induced [EMT] via JNK activation by PP2A down-regulation , and Tgase-2/PP2A/JNK might be a novel axis that affects N-cadherin switching in the EMT of A549 lung cancer cells . Positive_regulation SLC22A3 TNF 17665043 1776744 These results showed that can *promote* [epithelial-mesenchymal transition (EMT)] of MCF-7 cells . Positive_regulation SLC22A3 TNF 17665043 1776745 Thus , the activation of NFkappaB , which causes an increase in the expression of the transcription factor Snail is essential in the *induced* [EMT] . Positive_regulation SLC22A3 TNF 17665043 1776746 ROS caused by TNF-alpha seemed to play a minor role in the *induced* [EMT] of MCF-7 cells , though ROS per se can promote EMT . Positive_regulation SLC22A3 TNF 18294286 1891603 Moreover , *induced* the [EMT] of 786-O cells by repressing E-cadherin , promoting vimentin expression , and activating MMP9 activity . Positive_regulation SLC22A3 TNF 18792103 1986426 IL-1beta or alone can also *augment* TGF-beta1 induced [EMT] . Positive_regulation SLC22A3 TNF 19965872 2199598 The production of hyaluronan and its interaction with CD44 , thus , play an essential role in *induced* [EMT] and are potential therapeutic targets in fibrotic disorders . Positive_regulation SLC22A3 TNF 20128678 2207567 In conclusion , *enhances* not only [EMT] but also cell contraction induced by TGF-beta1 . Positive_regulation SLC22A3 TNF 20304956 2254866 Moreover , TNF-alpha induced EMT was impaired by antagonists against bone morphogen proteins (BMP) 2/4 , suggesting that BMP mediates the *induced* [EMT] in human skin . Positive_regulation SLC22A3 TNF 20350779 2281932 In contrast , NF-kappaB activation by or expression of constitutively active IKK2 *induced* an [EMT-phenotype] with up-regulation of vimentin and ZEB1 , and down-regulation of E-cadherin . Positive_regulation SLC22A3 TNF 21196756 2425340 We investigated whether TGF-ß1 and/or *induce* [EMT] in bronchial epithelial cells . Positive_regulation SLC22A3 TNF 21196756 2425342 [EMT] *induced* with TGF-ß1 plus promoted cell migration . Positive_regulation SLC22A3 TNF 21856755 2473272 In the present study , *induced* [epithelial-mesenchymal transition (EMT)] of RCC cells by repressing E-cadherin , promoting invasiveness and activating matrix metalloproteinase (MMP) 9 activity . Positive_regulation SLC22A3 TNF 21856755 2473280 To investigate the role of NF-?B activation in *induced* [EMT] of RCC , we employed chemical inhibitors ( NF-?B activation inhibitor and Bay 11-7082 ) and transfected dominant negative ( pCMV-I?BaM ) and overexpressive ( pFLAG-p65 ) vectors of NF-?B . Positive_regulation SLC22A3 TNF 22565852 2763352 Our preliminary observations suggest that may *induce* [EMT] in RTECs through inducing C3 expression . Positive_regulation SLC22A3 TNF 22707636 2643907 Inhibition of PI3K/AKT by LY294002 reactivated GSK-3ß and suppressed the *induced* [EMT] of RCC cells . Positive_regulation SLC22A3 TNF 23431386 2744400 [Epithelial-mesenchymal transition (EMT)] *induced* by requires AKT/GSK-3ß mediated stabilization of snail in colorectal cancer . Positive_regulation SLC22A3 TP63 23658742 2784761 We therefore investigated the *role* of in [EMT] . Positive_regulation SLC22A3 VSNL1 22479362 2578860 These findings indicate that is *involved* in [EMT] of SCC by regulating the transcription factor Snail1 in a cAMP dependent manner . Positive_regulation SLC23A1 HNF1B 19741195 2152890 Together , these data suggest that HNF-1alpha and/or binding is *required* for [SVCT1] expression and may be involved in the coordinate regulation of whole body vitamin C status . Positive_regulation SLC25A1 CAPN8 12857760 1141801 Oxidized lipoproteins inhibit surfactant phosphatidylcholine synthesis via *mediated* cleavage of [CTP] : phosphocholine cytidylyltransferase . Positive_regulation SLC25A1 PGC 21914785 2501626 In addition , [SLC25A1] and ACLY , which are required for the conversion of glucose into acetyl-CoA for fatty acid synthesis , were also *increased* by , thus linking the oxidative and lipogenic functions of PGC1a . Positive_regulation SLC25A10 F3 15389127 1300362 Experimental [DIC] was *induced* by sustained infusion of 50 mg/kg lipopolysaccharide (LPS) , or 3.75 U/kg , for 4 h via the rat tail vein . Positive_regulation SLC25A10 F3 15389127 1300364 The effect of administration of a non-selective endothelin receptor antagonist ( TAK-044 ) ( 2 , 10 , or 50 mg/kg , from -0.5 to 4 h ) on *induced* [DIC] was not significant . Positive_regulation SLC25A10 F3 229708 10194 ( 2 ) In *induced* [DIC] , heparin was slightly more effective than FOY or aprotinin . Positive_regulation SLC25A10 F3 3518133 58953 Tissue *induced* reversible [DIC] and heparin enhanced inhibitors in dogs . Positive_regulation SLC25A16 CA12 9315888 456122 The [GDPSP/C] was *dependent* on the availability of bicarbonate , but not on interstitial or intrapyramidal activity . Positive_regulation SLC25A20 PGC 22713466 2626877 *regulates* mouse [carnitine-acylcarnitine translocase] through estrogen related receptor a . Positive_regulation SLC25A20 PGC 22713466 2626879 We also demonstrate that XTC790 , the inverse agonist of ERRa , specifically blocks [Cact] *activation* by in C2C12 cells . Positive_regulation SLC25A3 CD22 8627166 355811 Transient expression of and a null mutant of PTP-1C ( PTP-1CM ) in COS cells *resulted* in an increase in tyrosyl phosphorylation of CD22 and its interaction with [PTP-1CM] . Positive_regulation SLC25A3 IGFBP1 10593604 572697 Treatment of B16F1 cells with [PTP] *inhibitors* , sodium orthovanadate ( Na3VO4 ) and phenylarsine oxide ( PAO ) , or inhibitor , okadaic acid ( OA ) , abolished cell movement . Positive_regulation SLC26A3 CTGF 17052405 1636208 This study investigated the *role* of in hyperoxia induced [CLD] . Positive_regulation SLC26A3 PDZK1 19447883 2101469 DRA also possesses a PDZ binding motif , but the *roles* of interactions with E3KARP or and Ca ( 2+ ) ( i ) in [DRA] regulation are unknown . Positive_regulation SLC26A6 PDZK1 17120766 1652189 Finally , we demonstrated an essential *role* for the scaffolding protein in apical membrane expression of [SLC26A6] . Positive_regulation SLC27A5 ALOX5 1934327 170100 Both <5LO> inhibition and LTD4 receptor antagonism *attenuated* the LPS induced [BAL] erythrocyte increase . Positive_regulation SLC27A5 LBP 9117029 423594 and sCD14 *increased* markedly in [BAL] of patients with ARDS . Positive_regulation SLC27A5 TNF 15242428 1270587 levels *increased* in ETX , but not in [BAL] , animals . Positive_regulation SLC28A1 HNF4A 19228884 2050430 In cotransfection experiments , the transcriptional coactivator peroxisome proliferator activated receptor-gamma coactivator-1alpha further increased , whereas the bile acid-inducible corepressor small heterodimer partner reduced , *dependent* [CNT1] promoter activity . Positive_regulation SLC28A1 IFNG 12868960 1149955 Interestingly , *led* to an induction of the [CNT1-] and CNT2 related nucleoside transport activities independent of STAT1 , thus ensuring the supply of extracellular nucleosides for the STAT1 independent RNA synthesis . Positive_regulation SLC28A1 IFNG 12868960 1149956 *up-regulated* CNT2 mRNA and [CNT1] protein levels and down-regulated ENT1 mRNA in both wild-type and STAT1 knockout macrophages . Positive_regulation SLC28A1 IL6 15464233 1305047 TNF-alpha and independently *induced* [CNT1] protein expression in cultured liver parenchymal and FAO hepatoma cells by PI-3 kinase- and ERK dependent mechanisms , respectively . Positive_regulation SLC28A1 INS 17537394 1778408 Overall , our results demonstrate that the expression level of ENT2 , [CNT1] , and CNT2 transporters in CFs is differentially *regulated* by . Positive_regulation SLC28A1 TNF 15464233 1305046 and IL-6 independently *induced* [CNT1] protein expression in cultured liver parenchymal and FAO hepatoma cells by PI-3 kinase- and ERK dependent mechanisms , respectively . Positive_regulation SLC28A1 TNF 15464233 1305050 This study identifies TNF-alpha as a major in vivo modulator of the nucleoside transporter CNT1 and suggests a secondary role for IL-6 in mediating [CNT1] *up-regulation* by in vivo . Positive_regulation SLC28A1 TNF 15464233 1305051 Evidence is provided that two independent pathways are involved in the *up-regulation* of [CNT1] by and IL-6 . Positive_regulation SLC2A1 ADRB2 24504055 2918682 *dependent* regulation of [GLUT-1] and HK-2 was determined by in vitro pharmacologic intervention . Positive_regulation SLC2A1 EPHB2 22107955 2534877 The effect of GnRH on [Glut1] mRNA expression is partly *mediated* by activation . Positive_regulation SLC2A1 IL1B 12915684 1130005 In vitro , [GLUT1] and GLUT3 were not directly *regulated* by 17beta-estradiol , progesterone , or , IL-6 , and leukemia inhibitory factor , but GLUT1 mRNA increased progressively in stromal cells , decidualized in vitro . Positive_regulation SLC2A1 IL1B 17038556 1674593 We demonstrated that slightly *increased* [Glut 1] translocation and basal glucose uptake in 3T3-L1 adipocytes . Positive_regulation SLC2A1 MAP2K6 11108276 756827 ET-1 induced 2-DOG uptake and [GLUT1] expression at 6 h were completely *inhibited* by the inhibitor , PD 98059 , and partially inhibited by the PI3-kinase inhibitor , LY 294002 , and the G alpha i inhibitor , pertussis toxin . Positive_regulation SLC2A1 MAP2K6 11279172 819617 Constitutively active mutants *up-regulated* [GLUT1] expression and down-regulated GLUT4 expression , thereby significantly increasing basal glucose transport but diminishing transport induced by insulin . Positive_regulation SLC2A1 MAP2K6 15307820 1333314 In the present study , we show that PMA treatment increases glucose uptake in 3T3-L1 adipocytes by two mechanisms : a *dependent* increase in [GLUT1] ( glucose transporter 1 ) expression levels and a PKClambda dependent translocation of GLUT1 towards the plasma membrane . Positive_regulation SLC2A1 PPBP 1527075 197537 The increased levels of [GLUT-1] protein in *response* to and rCTAP-III-Leu-21 ( des-1-15 ) /NAP-2 were accompanied by an increase in levels of GLUT-1 mRNA of a magnitude sufficient to account for observed increased levels of GLUT-1 . Positive_regulation SLC2A1 TNF 10542046 563566 Rather , *increased* membrane expression of [GLUT1] and glucose transport in these muscle cells . Positive_regulation SLC2A10 INS 12890477 1117267 3T3-L1 adipocytes express [GLUT-10] , but not GLUT-12 , and expression of GLUT-12 was not *induced* by or glucose . Positive_regulation SLC2A3 IL1B 11739520 886550 [GLUT3] and GLUT8 mRNA are constitutively expressed in chondrocytes and are not *regulated* by . Positive_regulation SLC2A3 IL1B 12915684 1130008 In vitro , GLUT1 and [GLUT3] were not directly *regulated* by 17beta-estradiol , progesterone , or , IL-6 , and leukemia inhibitory factor , but GLUT1 mRNA increased progressively in stromal cells , decidualized in vitro . Positive_regulation SLC2A4 EDN2 10075711 595027 *stimulates* glucose uptake and [GLUT4] translocation via activation of endothelin ETA receptor in 3T3-L1 adipocytes . Positive_regulation SLC2A4 FOXO1 12414908 1011215 Therefore , we evaluated the *role* of in the regulation of [GLUT4] gene expression in muscle tumorigenesis . Positive_regulation SLC2A4 GLP1R 23051671 2720689 In addition , stimulation of the in cardiomyocytes isolated from SHRs *increased* the protein level of [GLUT4] by 154 ± 13 % . Positive_regulation SLC2A4 IRS4 10077007 595272 Nevertheless , as demonstrated in this study , both IRS-3 and can also *stimulate* translocation of [GLUT4] . Positive_regulation SLC2A4 MAP2K6 15172888 1288344 Inhibition of with U-0126 did not *prevent* [GLUT4] from translocating to the plasma membrane , nor did it inhibit the subsequent docking and fusion of GLUT4-myc with the plasma membrane . Positive_regulation SLC2A4 PGC 12468452 1022566 These findings suggest that increases in , NRF-1 , and NRF-2 represent key regulatory components of the stimulation of mitochondrial biogenesis by exercise and that PGC-1 *mediates* the coordinated increases in [GLUT4] and mitochondria . Positive_regulation SLC2A4 RAB31 12637568 1079912 Insulin stimulated phosphorylation of a GTPase activating protein *regulates* [GLUT4] translocation . Positive_regulation SLC2A4 RAB31 19740738 2152874 Prior studies have shown that Akt phosphorylation of the GTPase activating protein , AS160 ( 160-kDa Akt substrate ; also known as TBC1D4 ) , *triggers* [GLUT4] translocation , most likely by suppressing its Rab GTPase activating protein activity . Positive_regulation SLC2A4 TNF 16754199 1571437 Moreover , inhibition of the ceramide biosynthesis with fumonisin B , which inhibits ceramide synthase , completely restored insulin induced GLUT4 mRNA and protein accumulation as well as [GLUT4-CAT] transactivation in the *presence* of . Positive_regulation SLC2A4 TNF 18162526 1883084 The stimulatory effects of TNFalpha on cell surface [GLUT4] and glucose uptake were blocked by nuclear factor-kappaB and p38MAPK pathway specific inhibitors ( Bay 11-7082 and SB220025 ) , and these two pathways were *stimulated* by . Positive_regulation SLC2A4RG CAPN8 9045698 416417 Accordingly , the [GEF] activity of CDC25 ( Mm ) was *increased* severalfold by the Ca2+ dependent protease that cleaves around a PEST-like region ( residues 798-853 ) , producing C-terminal fragments of 43-56 kDa . Positive_regulation SLC2A4RG GPR115 10882715 730232 Ras-GRF1 is a brain-specific [guanine nucleotide exchange factor (GEF)] for Ras , whose activity is regulated in *response* to Ca ( 2+ ) influx and signals . Positive_regulation SLC2A4RG GPR132 10882715 730221 Ras-GRF1 is a brain-specific [guanine nucleotide exchange factor (GEF)] for Ras , whose activity is regulated in *response* to Ca ( 2+ ) influx and signals . Positive_regulation SLC2A4RG GPR87 10882715 730301 Ras-GRF1 is a brain-specific [guanine nucleotide exchange factor (GEF)] for Ras , whose activity is regulated in *response* to Ca ( 2+ ) influx and signals . Positive_regulation SLC2A4RG RAB31 20797862 2324390 *requires* a [guanine nucleotide exchange factor (GEF)] for its conversion to the active GTP form . Positive_regulation SLC2A4RG TLR7 22231169 2544676 As p-eIF2a decreases the functional interaction of eIF2 with eIF2B , a guanine nucleotide exchange factor (GEF) , we explored the hypothesis that signalling *activates* eIF2B [GEF] activity to counteract the effects of p-eIF2a . Positive_regulation SLC2A4RG TLR7 22231169 2544686 We now show that signalling *activates* eIF2B [GEF] through PP2A mediated serine dephosphorylation of the eIF2B ?-subunit . Positive_regulation SLC31A2 ITGB2 22445756 2582883 Taken together , our results suggest that can *activate* the expression of vacuolar copper transporter [Ctr2p] in response to copper deficiency , resulting in yeast resistance to copper starvation . Positive_regulation SLC33A1 ANGPT1 12586636 1084940 The lisinopril-insensitive response may be related to conversion by unknown enzyme ( s ) and/or to *activation* of [AT(1)] receptors by . Positive_regulation SLC33A1 ANGPT1 14737832 1202857 When [AT1] receptor is blocked and unbound Ang II may act on AT2 receptor and and Ang IV via AT4 receptor might be *involved* in the effects of ARB . Positive_regulation SLC33A1 ANGPT1 18084722 1882975 Role of ACE/AT2R complex in the control of mesenteric resistance artery contraction induced by [ACE/AT1R] complex activation in *response* to . Positive_regulation SLC33A1 CTGF 22964022 2678757 In this paper , we show that in myoblasts , Ang-II *induced* the increase of transforming growth factor beta 1 ( TGF-ß1 ) and expression through its [AT-1] receptor . Positive_regulation SLC33A1 EPHB2 17212359 1717699 *Activation* of , JNK , Akt , and G-protein coupled signaling by hybrid angiotensin II [AT1/bradykinin] B2 receptors expressed in HEK-293 cells . Positive_regulation SLC33A1 EPHB2 20492449 2283510 In contrast , the AT1 IC2 peptide had no effect on [AngII/AT1] receptor *activation* of . Positive_regulation SLC33A1 FAS 10325958 612830 During exposure of HCAECs to anoxia-reoxygenation and Ang II , [AT1R] activation *induces* important changes in cNOS mRNA , protein expression and activity , as well as bcl-2 and protein expression which may have a bearing on the development of apoptosis . Positive_regulation SLC33A1 IL1B 15733910 1378007 The results show that more rapidly *induces* [AT(1)] receptor upregulation than does TNF-alpha , an effect that can be mimicked by a NF-kappaB dependent luciferase reporter gene . Positive_regulation SLC33A1 IL1B 16427616 1534068 *enhanced* the expression of [AT1] in astrocytes in time- and concentration dependent manners . Positive_regulation SLC33A1 TGM2 18326554 1919562 Intracellular *enhances* [AT1] signalling by cross linking AT1 homodimers . Positive_regulation SLC33A1 TGM2 18326554 1919569 [AT1] dimer protein levels were increased in WT mesenteric arterioles treated with 10 ( -7 ) M aldosterone , and the inhibitor and AT1 blocker *blocked* this aldosterone induced formation of AT1 dimer . Positive_regulation SLC33A1 TNF 11600498 903811 These results suggest that low but persistent IKK activity and I kappa B degradation lead to prolonged NF-kappa B nuclear translocation and maximal [AT(1)] up-regulation in the continued *presence* of . Positive_regulation SLC33A1 TNF 12480812 1024241 *induced* [AT1] receptor upregulation enhances angiotensin II-mediated cardiac fibroblast responses that favor fibrosis . Positive_regulation SLC33A1 TNF 12480812 1024243 We sought to determine if *induced* [AT1] receptor upregulation alters fibroblast responsiveness to Ang II and if this effect differs from direct TNF-alpha effects on fibroblast functions . Positive_regulation SLC33A1 TNF 12480812 1024246 In cardiac fibroblasts with *induced* [AT1] receptor upregulation , Ang II-stimulated [ 3H ] proline incorporation and TIMP-1 protein production was approximately 2-fold greater than in nonpretreated fibroblasts . Positive_regulation SLC33A1 TNF 12480812 1024247 Thus , *induced* [AT1] receptor upregulation enhances Ang II-mediated functions that favor fibrosis . Positive_regulation SLC33A1 TNF 18852381 1988771 The purpose of this study was to determine the *role* of placental ischemia and in stimulating the [AT1-AA] and the importance of AT1 receptor activation in mediating hypertension during reductions in uterine perfusion pressure ( RUPP ) and chronic TNF-alpha excess in pregnant rats . Positive_regulation SLC33A1 TNF 9231818 445007 and interferon gamma did not *cause* a significant change in [AT1] binding when administered alone but caused a 30 % reduction in binding when administered together ( P < .05 ) . Positive_regulation SLC38A3 CCK 14602717 1187567 [G17] *activation* of the receptor ( CCK ( 2 ) R ) , a G protein coupled receptor , stimulates release of Ca2+ from inositol 1,4,5-triphosphate-sensitive Ca2+ stores . Positive_regulation SLC38A3 ELK4 9950815 595752 [G17] *induced* the transcriptional activity of both Elk-1 and , transcription factors that bind to the E26 transformation specific (Ets) DNA sequence of the SRE , and this effect was inhibited by both GF-109203X and PD-98059 . Positive_regulation SLC38A3 GAST 14602717 1187568 [G17] *activation* of the receptor ( CCK ( 2 ) R ) , a G protein coupled receptor , stimulates release of Ca2+ from inositol 1,4,5-triphosphate-sensitive Ca2+ stores . Positive_regulation SLC38A3 KCNH4 9950815 595753 [G17] *induced* the transcriptional activity of both and Sap-1a , transcription factors that bind to the E26 transformation specific (Ets) DNA sequence of the SRE , and this effect was inhibited by both GF-109203X and PD-98059 . Positive_regulation SLC38A3 MAP2K1 10362639 620085 [G17] stimulation of GH3 cell proliferation was completely *blocked* by the CCKB receptor antagonist D2 but not by the inhibitor PD-98059 or the protein kinase C inhibitor GF-109203X , which completely inhibited G17 induction of AR42J cell proliferation . Positive_regulation SLC38A3 MAP2K2 10362639 620086 [G17] stimulation of GH3 cell proliferation was completely *blocked* by the CCKB receptor antagonist D2 but not by the inhibitor PD-98059 or the protein kinase C inhibitor GF-109203X , which completely inhibited G17 induction of AR42J cell proliferation . Positive_regulation SLC38A3 MAP2K3 10362639 620087 [G17] stimulation of GH3 cell proliferation was completely *blocked* by the CCKB receptor antagonist D2 but not by the inhibitor PD-98059 or the protein kinase C inhibitor GF-109203X , which completely inhibited G17 induction of AR42J cell proliferation . Positive_regulation SLC38A3 MAP2K4 10362639 620088 [G17] stimulation of GH3 cell proliferation was completely *blocked* by the CCKB receptor antagonist D2 but not by the inhibitor PD-98059 or the protein kinase C inhibitor GF-109203X , which completely inhibited G17 induction of AR42J cell proliferation . Positive_regulation SLC38A3 MAP2K5 10362639 620089 [G17] stimulation of GH3 cell proliferation was completely *blocked* by the CCKB receptor antagonist D2 but not by the inhibitor PD-98059 or the protein kinase C inhibitor GF-109203X , which completely inhibited G17 induction of AR42J cell proliferation . Positive_regulation SLC38A3 MAP2K6 10362639 620090 [G17] stimulation of GH3 cell proliferation was completely *blocked* by the CCKB receptor antagonist D2 but not by the inhibitor PD-98059 or the protein kinase C inhibitor GF-109203X , which completely inhibited G17 induction of AR42J cell proliferation . Positive_regulation SLC38A3 MAP2K7 10362639 620091 [G17] stimulation of GH3 cell proliferation was completely *blocked* by the CCKB receptor antagonist D2 but not by the inhibitor PD-98059 or the protein kinase C inhibitor GF-109203X , which completely inhibited G17 induction of AR42J cell proliferation . Positive_regulation SLC38A3 MAPK1 15331357 1287895 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Positive_regulation SLC38A3 MAPK10 15331357 1287896 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Positive_regulation SLC38A3 MAPK11 15331357 1287897 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Positive_regulation SLC38A3 MAPK12 15331357 1287898 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Positive_regulation SLC38A3 MAPK13 15331357 1287899 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Positive_regulation SLC38A3 MAPK14 15331357 1287900 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Positive_regulation SLC38A3 MAPK15 15331357 1287894 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Positive_regulation SLC38A3 MAPK3 15331357 1287901 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Positive_regulation SLC38A3 MAPK4 15331357 1287902 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Positive_regulation SLC38A3 MAPK6 15331357 1287903 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Positive_regulation SLC38A3 MAPK7 15331357 1287904 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Positive_regulation SLC38A3 MAPK8 15331357 1287905 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Positive_regulation SLC38A3 MAPK9 15331357 1287906 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Positive_regulation SLC38A3 RHOA 9950815 595757 Because activation of the SRE involves the small GTP binding protein Rho A , we examined the *role* of in [G17] induction of c-fos transcription . Positive_regulation SLC39A8 TNF 22345571 2586668 treatment of primary human lung epithelia and A549 cells *induced* [ZIP8] expression , resulting in significantly higher cell death attributable to both apoptosis and necrosis following Cd exposure . Positive_regulation SLC3A2 IL1B 19892711 2188649 In a pathological context , the pro-inflammatory cytokine *increased* [CD98] expression in Caco2-BBE cells by decreasing microRNA-7 levels . Positive_regulation SLC3A2 ITGB2 11165259 782749 [CD98] *induces* mediated cell adhesion in lymphoid cells via activation of Rap1 . Positive_regulation SLC3A2 ITGB2 11165259 782752 We show that [CD98] cross linking persistently activates Rap1 GTPase in a LFA-1 dependent manner and *induces* mediated cell adhesion in lymphocytes . Positive_regulation SLC4A2 MAP2K6 21143204 2425159 We also found that [AE2] could *induce* the phosphorylation of p38 MAPK ( mitogen activated protein kinase ) , ERK1/2 ( extracellular-signal regulated kinase 1/2 ) , ( MAPK/ERK kinase ) and JNK ( c-Jun N-terminal kinase ) , whereas it failed to induce phosphorylation of JAK2 ( Janus kinase 2 ) and STAT1 . Positive_regulation SLC4A4 ANGPT1 8396341 230293 ( 10 ( -9 ) M ) and ANG III ( 10 ( -10 ) M ) also *stimulated* the [Na(+)-HCO3- cotransporter] , and captopril ( 10 ( -4 ) M ) attenuated the ANG I stimulation by 68 +/- 3.5 % ( P < 0.01 ) but not that of ANG II and III . Positive_regulation SLC4A4 CA12 12881227 1185367 In conclusion , only specific apical NHE3 inhibition increased DBS , whereas prostaglandin synthesis , [Na+-HCO3- cotransporter] *activation* , or intracellular HCO3- formation by was not involved . Positive_regulation SLC5A1 TNF 17177295 1717263 On the contrary , *increased* [SGLT1] mRNA levels . Positive_regulation SLC5A2 TNF 22351116 2636705 In conclusion , this study showed that [SGLT2] increased in the *presence* of IL-6 and , indicating an autocrine modulation of the expression of this transporter by cytokines . Positive_regulation SLC6A2 ANG 9030625 414726 MAP kinase stimulation is a key signaling event in the AT1 receptor (AT1R) mediated chronic *stimulation* of tyrosine hydroxylase and [norepinephrine transporter] in brain neurons by . Positive_regulation SLC6A2 CDK2 16713564 1564848 The sister chromatid separating protease separase , activated at anaphase onset , interacts with and downregulates PP2A ( Cdc55 ) , thereby facilitating *dependent* [Net1] phosphorylation . Positive_regulation SLC6A2 CEBPA 21883217 2491512 Dexamethasone induced up-regulation of the human [norepinephrine transporter] *involves* the glucocorticoid receptor and increased binding of to the proximal promoter of norepinephrine transporter . Positive_regulation SLC6A2 DLG1 19586902 2122601 Furthermore , we show that Net1 is an unstable protein in MCF7 breast epithelial cells and that interaction with significantly *enhances* [Net1] stability . Positive_regulation SLC6A2 EDN1 18682267 1984590 Conversely , in the anterior hypothalamic region endothelin-3 *enhanced* neuronal [norepinephrine transporter] activity by increasing the expression of the transporter on the presynaptic membrane , whereas induced the opposite effect . Positive_regulation SLC6A2 EDN3 18682267 1984591 Conversely , in the anterior hypothalamic region *enhanced* neuronal [norepinephrine transporter] activity by increasing the expression of the transporter on the presynaptic membrane , whereas endothelin-1 induced the opposite effect . Positive_regulation SLC6A2 HAND2 21241805 2392409 Cytokines *inhibit* [norepinephrine transporter] expression by decreasing . Positive_regulation SLC6A2 NR3C1 21883217 2491513 Dexamethasone induced up-regulation of the human [norepinephrine transporter] *involves* the and increased binding of C/EBP-ß to the proximal promoter of norepinephrine transporter . Positive_regulation SLC6A2 PAK1 15684429 1382335 These data provide a novel mechanism for the control of RhoA activity by Rac1 through the *dependent* phosphorylation of [NET1] to reduce its activity as a guanine nucleotide exchange factor . Positive_regulation SLC6A2 PAK2 15684429 1382336 These data provide a novel mechanism for the control of RhoA activity by Rac1 through the *dependent* phosphorylation of [NET1] to reduce its activity as a guanine nucleotide exchange factor . Positive_regulation SLC6A2 PAK3 15684429 1382337 These data provide a novel mechanism for the control of RhoA activity by Rac1 through the *dependent* phosphorylation of [NET1] to reduce its activity as a guanine nucleotide exchange factor . Positive_regulation SLC6A2 PAK4 15684429 1382333 These data provide a novel mechanism for the control of RhoA activity by Rac1 through the *dependent* phosphorylation of [NET1] to reduce its activity as a guanine nucleotide exchange factor . Positive_regulation SLC6A2 PAK6 15684429 1382334 These data provide a novel mechanism for the control of RhoA activity by Rac1 through the *dependent* phosphorylation of [NET1] to reduce its activity as a guanine nucleotide exchange factor . Positive_regulation SLC6A2 PAK7 15684429 1382332 These data provide a novel mechanism for the control of RhoA activity by Rac1 through the *dependent* phosphorylation of [NET1] to reduce its activity as a guanine nucleotide exchange factor . Positive_regulation SLC6A2 PHOX2A 10037744 592263 A previously undescribed intron and extensive 5 ' upstream sequence , but not mediated transactivation , are *necessary* for high level cell type-specific expression of the human [norepinephrine transporter] gene . Positive_regulation SLC6A2 PKN1 15684429 1382330 negatively *regulates* the activity of the Rho exchange factor [NET1] . Positive_regulation SLC6A2 RAC1 23792411 2824262 Recently we have shown that activation *stimulates* plasma membrane relocalization and activation of [Net1A] . Positive_regulation SLC6A2 SLC33A1 9030625 414727 MAP kinase stimulation is a key signaling event in the *mediated* chronic stimulation of tyrosine hydroxylase and [norepinephrine transporter] in brain neurons by angiotensin II (Ang II) . Positive_regulation SLC6A2 SLC6A3 12354632 993630 mRNA expression of [norepinephrine transporter (NET)] and serotonin transporter ( SERT ) has been *detected* in a conditionally immortalized mouse brain capillary endothelial cell line ( TM-BBB4 ) used as an in vitro model of the BBB , whereas no was detected . Positive_regulation SLC6A2 SLC6A3 23261499 2741347 Thirteen of the test substances acted as inhibitors of monoamine uptake at submicromolar concentrations , including 9 potent inhibitors of the , 12 potent *inhibitors* of the [norepinephrine transporter (NET)] and 4 potent inhibitors of the serotonin transporter ( SERT ) . Positive_regulation SLC6A2 SMAD1 21986943 2605109 signaling and the MAPK/ERK kinase (MEK)/extracellular signal regulated kinase ( ERK ) pathway were *involved* in [Net1A] upregulation by TGF-ß . Positive_regulation SLC6A2 SMAD2 21986943 2605110 signaling and the MAPK/ERK kinase (MEK)/extracellular signal regulated kinase ( ERK ) pathway were *involved* in [Net1A] upregulation by TGF-ß . Positive_regulation SLC6A2 SMAD3 21986943 2605111 signaling and the MAPK/ERK kinase (MEK)/extracellular signal regulated kinase ( ERK ) pathway were *involved* in [Net1A] upregulation by TGF-ß . Positive_regulation SLC6A2 SMAD4 21986943 2605112 signaling and the MAPK/ERK kinase (MEK)/extracellular signal regulated kinase ( ERK ) pathway were *involved* in [Net1A] upregulation by TGF-ß . Positive_regulation SLC6A2 SMAD5 21986943 2605113 signaling and the MAPK/ERK kinase (MEK)/extracellular signal regulated kinase ( ERK ) pathway were *involved* in [Net1A] upregulation by TGF-ß . Positive_regulation SLC6A2 SMAD6 21986943 2605114 signaling and the MAPK/ERK kinase (MEK)/extracellular signal regulated kinase ( ERK ) pathway were *involved* in [Net1A] upregulation by TGF-ß . Positive_regulation SLC6A2 SMAD7 21986943 2605115 signaling and the MAPK/ERK kinase (MEK)/extracellular signal regulated kinase ( ERK ) pathway were *involved* in [Net1A] upregulation by TGF-ß . Positive_regulation SLC6A2 SMAD9 21986943 2605116 signaling and the MAPK/ERK kinase (MEK)/extracellular signal regulated kinase ( ERK ) pathway were *involved* in [Net1A] upregulation by TGF-ß . Positive_regulation SLC6A2 SYN1 17714497 1794745 We demonstrate that *regulates* the activity and surface expression of the [norepinephrine transporter (NET)] , depending on its expression levels . Positive_regulation SLC6A2 SYN2 17714497 1794746 We demonstrate that *regulates* the activity and surface expression of the [norepinephrine transporter (NET)] , depending on its expression levels . Positive_regulation SLC6A2 SYN3 17714497 1794747 We demonstrate that *regulates* the activity and surface expression of the [norepinephrine transporter (NET)] , depending on its expression levels . Positive_regulation SLC6A3 SLC6A2 11739781 886721 When expressed in epithelial cells , [dopamine transporter (DAT)] was *detected* predominantly in the apical plasma membrane , whereas was found in the basolateral membrane , despite 67 % overall amino acid sequence identity . Positive_regulation SLC6A3 SLC6A2 23261499 2741348 Thirteen of the test substances acted as inhibitors of monoamine uptake at submicromolar concentrations , including 9 potent *inhibitors* of the [dopamine transporter (DAT)] , 12 potent inhibitors of the and 4 potent inhibitors of the serotonin transporter ( SERT ) . Positive_regulation SLC6A4 CAPN8 12077181 956979 These results suggest that cleavage of [Htt] in human HD tissue is *mediated* in part by the Ca2+ activated neutral protease , . Positive_regulation SLC6A4 IL1B 15927991 1414242 MCT induced PH was also associated with increased expression of various cytokines , but only and monocyte chemotactic protein-1 increased at the early phase and *stimulated* [5-HTT] expression by cultured PA-SMCs . Positive_regulation SLC7A1 TNF 9473147 476319 ( 10 ng/ml for 1-24 h ) induced a time dependent *increase* in CAT-2 but not [CAT-1] expression . Positive_regulation SLC7A2 TNF 15238257 1269887 *causes* an increased expression of [SLC7A2/CAT-2B] gene while SLC7A1/CAT-1 expression is not altered by the cytokine . Positive_regulation SLC7A2 TNF 9473147 476320 ( 10 ng/ml for 1-24 h ) induced a time dependent *increase* in [CAT-2] but not CAT-1 expression . Positive_regulation SLC7A2 TNF 9473147 476323 Moreover , ( 1-30 ng/ml ) treatment for 6 h *induced* a concentration dependent increase in [CAT-2] mRNA expression . Positive_regulation SLC7A2 TNF 9473147 476324 The *upregulation* of [CAT-2] expression by was associated with enhanced nitrite accumulation in the culture medium ( 70 % increase compared with vehicle treated cells at 24 h ) . Positive_regulation SLC8A1 EPHB2 12502566 1026778 Inhibition of with the MEK inhibitor UO126 , the ERK protein phosphatase MKP-3 , inhibited ERK activation , but only *inhibited* alpha-adrenergic induced [NCX1] upregulation by 30 % . Positive_regulation SLC8A1 EPHB2 12502566 1026780 Together , this data indicates that ( 1 ) JNK mediates basal cardiac expression of the NCX1 gene , ( 2 ) and p38 play a role in alpha-adrenergic stimulated NCX1 upregulation , and ( 3 ) p38 activation alone is *sufficient* for [NCX1] upregulation . Positive_regulation SLC8A3 CAPN8 19937813 2210136 Calpeptin , an inhibitor of , significantly *attenuated* [NCX3] degradation but failed to inhibit DCD and excitotoxic neuronal death . Positive_regulation SLC9A1 ADRB2 8106440 245966 We previously demonstrated that the and other receptors that stimulate adenylyl cyclase by activating Gs *stimulate* [NHE1] by a guanine nucleotide dependent mechanism that is independent of receptor coupling to Gs . Positive_regulation SLC9A1 CAPN8 24594116 2929637 *Activation* of [Na(+)/H(+) exchanger 1] ( NHE1 ) by lipopolysaccharide (LPS) via Ca ( 2+ ) is responsible in vascular smooth muscle cell ( VSMC ) apoptosis and to the process of atherosclerosis . Positive_regulation SLC9A1 EPHB2 15494214 1354853 The data indicate that activation is *essential* for phenylephrine stimulation of [NHE1] , and that ERK and RhoA are involved in LPA stimulation of NHE1 by more than one mechanism . Positive_regulation SLC9A1 EPHB2 15494214 1354867 These studies indicate a direct involvement of ERK in the alpha ( 1 ) -adrenergic activation of [NHE1] and a significant *role* for both and RhoA in LPA stimulation of NHE1 in CCL39 fibroblasts . Positive_regulation SLC9A1 EPHB2 19542484 2109868 We recently demonstrated that *mediated* activation of [NHE1] occurs during ischemia-reperfusion of the myocardium . Positive_regulation SLC9A1 EPHB2 19542484 2109869 The same amino acids were critical to phenylephrine mediated , *dependent* activation of [NHE1] activity and increased the phosphorylation in intact rat cardiomyocytes . Positive_regulation SLC9A1 SLC9A2 10684820 669721 These results , when interpreted along with those of previous functional studies , may suggest that the apical is *involved* in Na ( + ) reabsorption and the basolateral [NHE1] in HCO ( 3 ) ( - ) secretion in the rat epididymis . Positive_regulation SLC9A1 SLC9A2 12474076 1023513 The results obtained strongly suggest that NHE-1 and NHE-2 are expressed in the basolateral membrane but that they have different roles : [NHE-1] is responsible for pHi recovery after an acid load and is mainly *involved* in steady-state pHi and cell volume regulation . Positive_regulation SLC9A2 EGF 11443049 833682 *increased* functional [NHE2] activity and mRNA abundance in cultured RIE cells , and this stimulation could be blocked by actinomycin D ( a transcriptional inhibitor ) . Positive_regulation SLC9A2 EGR1 15976391 1452524 Zinc finger transcription factor is *involved* in stimulation of [NHE2] gene expression by phorbol 12-myristate 13-acetate . Positive_regulation SLC9A2 EGR1 15976391 1452529 In cotransfection experiments , was able to *transactivate* the [NHE2] promoter . Positive_regulation SLC9A2 SLC9A3 8674384 358895 Luminal amiloride was administered from the second to the fourth hours at doses of 20 microM in groups 3 and 4 to *inhibit* NHE1 and [NHE2] , and 1mM in groups 5 and 6 to also inhibit . Positive_regulation SLC9A2 SP1 17561809 1785918 The results in the present study indicate that and Sp3 are *required* for constitutive [NHE2] expression and that the positive regulatory elements of the 5'-UTR may co-operate with the 5'-flanking region to achieve the optimal promoter activity . Positive_regulation SLC9A2 SP3 17561809 1785919 The results in the present study indicate that Sp1 and are *required* for constitutive [NHE2] expression and that the positive regulatory elements of the 5'-UTR may co-operate with the 5'-flanking region to achieve the optimal promoter activity . Positive_regulation SLC9A3 EDN2 11413164 828468 In cultured renal epithelial cells , activation of the ( ET ( B ) ) receptor *increases* [NHE3] activity . Positive_regulation SLC9A3 EPHB2 12081562 958405 *Role* of c-SRC and in acid induced activation of [NHE3] . Positive_regulation SLC9A3 MAP2K6 12081562 958416 Inhibition of with PD98059 *inhibited* activation of [NHE3] by acid incubation . Positive_regulation SLC9A3 MAP2K6 21832242 2495678 LPA ( 5 ) -dependent activation of [NHE3] was *blocked* by mitogen activated protein kinase kinase ( ) inhibitor PD98059 and U0126 , but not by phosphatidylinositol 3-kinase inhibitor LY294002 or phospholipase C-ß inhibitor U73122 . Positive_regulation SLC9A3 MAP2K6 24076179 2874207 These results indicate that after 30 min , Ang II treatment may activate G protein dependent pathways , including the AT1/PLC/Ca ( 2+ ) /CaM pathway , which induces CaMKII phosphorylation to stimulate [NHE3] and *induces* ( RSK ) activity to stimulate NHE1 . Positive_regulation SLC9A3 PDZK1 16141316 1454858 To determine whether interaction is *essential* for brush border localization of [NHE3] and CFEX in vivo , we examined the expression of NHE3 and CFEX in kidneys of wild-type and PDZK1-null mutant mice by both Western analysis and immunocytochemistry . Positive_regulation SLC9A3 PDZK1 17395628 1748528 This study was undertaken to understand the physiological *role* of in regulating [NHE3] activity in native murine colonic enterocytes . Positive_regulation SLC9A3 TNF 12021528 943215 Selective induction of NHE-3 and TNF-alpha , and their reversal by cox-2 inhibition , suggest a cox-2 dependent regulation of [NHE-3] , which possibly *involves* released from the site of inflammation and not from the kidney in colitis . Positive_regulation SLC9A3 TNF 16760259 1624939 IFN-gamma and *regulate* human [NHE3] gene expression by modulating the Sp family transcription factors in human intestinal epithelial cell line C2BBe1 . Positive_regulation SLC9A3 TNF 18785066 2012161 These findings suggest a *role* of in the regulation of [NHE-3] expression in IBD . Positive_regulation SLC9A3R1 PODXL 15339978 1291517 activates RhoA and *induces* actin reorganization through [NHERF1] and Ezrin in MDCK cells . Positive_regulation SLCO1A2 PDZK1 21183661 2396706 Thus , although binding is *required* for optimal cell surface expression of [oatp1a1] , phosphorylation provides a mechanism for fast regulation of the distribution of oatp1a1 between the cell surface and intracellular vesicular pools . Positive_regulation SLCO6A1 ARSA 16267095 1532081 Compared with untreated Min mice , *increased* in the liver the activity ( nmol/min/mg ; mean+/-SEM for all ) of NQO ( 85+/-6 versus 128+/-11 , P < 0.05 ) and [GST] ( 2560+/-233 versus 4254+/-608 , P < 0.005 ) and also in the intestine but not in the kidney ; Positive_regulation SLCO6A1 EPHB2 11409852 826364 In bovine aortic endothelial cells , [GST-Tat] and the 165 amino acid VEGF isoform ( VEGF165 ) *induce* transient ( 1/2 ) phosphorylation with similar potency and kinetics . Positive_regulation SLCO6A1 EPHB2 11409852 826369 Accordingly , [GST-Tat] *induces* ( 1/2 ) phosphorylation in KDR transfected porcine aortic endothelial cells but not in parental cells . Positive_regulation SLCO6A1 FAS 19417161 2179821 Our data show that in kidney cancer cells [GST-MDA-7] *induces* ceramide dependent activation of , which is causal in promoting an endoplasmic reticulum stress response that activates multiple proapoptotic pathways to decrease survival . Positive_regulation SLPI ARSA 11598899 870538 *induced* [ALP] activity and protein in cells in conventional monolayer culture . Positive_regulation SLPI ARSA 11598899 870540 In contrast , did not *cause* [ALP] induction in cells cultured on and in polymerized type I collagen gels . Positive_regulation SLPI ARSA 11598899 870541 Collagen fibrils inhibited the *up-regulation* by of [ALP] expression in cells plated on FN . Positive_regulation SLPI ARSA 11598899 870544 These results indicate that the ECM regulates the induction of ALP expression by AsA in fibroblasts : FN enables them to express [ALP] in *response* to through interaction with integrin alpha 5 beta 1 , whereas type I collagen fibrils cause the suppression of ALP expression and overcome FN . Positive_regulation SLPI ARSA 17664058 1793895 significantly *increased* [ALP] activity after 4 d , and this activation was inhibited by the CK2 inhibitors , 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole and 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazimidazole . Positive_regulation SLPI ARSA 2510469 120502 Indomethacin and *enhanced* [ALP] activity , whereas flurbiprofen and piroxicam suppressed it . Positive_regulation SLPI CTGF 23722620 2853920 Our results revealed that *induced* the expression of several bone markers , including [alkaline phosphatase (ALP)] , osteocalcin (OC) , osteoprotegerin (OPG) and core binding factor subunit a1 ( Cbfa1 ) /runt related transcription factor 2 ( Runx2 ) , as well as calcification . Positive_regulation SLPI EPHB2 15013846 1220727 The data presented in this study support the conclusion that , in MG-63 osteoblasts ( i ) the increase in [ALP] activity by flavonols *involves* a rapid stimulation of activation but also involves the ER , and that ( ii ) the activation of ERK by flavonols occurs most likely downstream of the ERs activation . Positive_regulation SLPI EPHB2 20828597 2336536 CKS induced enhancement of RUNX2 and [ALP] was *inhibited* by treatment with a p38 inhibitor ( SB203580 ) and an inhibitor ( U0126 ) . Positive_regulation SLPI IL1B 11171635 784062 In contrast , markedly *increased* the activity , protein , and mRNA of the bone-type [ALP] only when RA was present . Positive_regulation SLPI IL1B 16355004 1492660 *induced* [SLPI] promoter activity was suppressed by E1A gene transfection into A549 cells . Positive_regulation SLPI IL1B 7946401 276753 In addition , we show that and tumor necrosis factor *induce* significant [SLPI] expression and are major inducers of elafin/pre-elafin expression . Positive_regulation SLPI IL1B 9213003 441534 alone had no effect on ALP activity , but it significantly *enhanced* BMP-2- and -4-induced [ALP] activity . Positive_regulation SLPI KLF9 16384861 1533373 Forced expression of , either by stable or transient transfections of BTEB1 expression constructs in endometrial carcinoma cells , *enhanced* [SLPI] promoter activity . Positive_regulation SLPI TNF 12114316 964020 and OSM , only when applied together , *increased* [ALP] activities and in vitro calcification in HVSMCs in the presence of IFN-gamma and 1,25 ( OH ) 2D3 . Positive_regulation SLPI TNF 17114478 1651568 In this study , we show that [SLPI] , but not S100A4 , was *induced* in 3LL-S cells both in vitro and in vivo by , and that silencing of in vivo induced 3LL-S SLPI expression using RNA interference abrogated in vivo progression but did not influence TNF-alpha resistance . Positive_regulation SLPI TNF 20004646 2199810 MSX2 over-expression alone induced ALP expression , whereas knockdown of MSX2 with small interfering RNA completely blocked *induced* [ALP] expression . Positive_regulation SLPI TNF 22447223 2588500 ( 5 ng/mL ) *resulted* in an increase in apoptosis and a reduction in [ALP] activity in the cells . Positive_regulation SLPI TNF 23657597 2819237 and IL-1ß *enhanced* the [alkaline phosphatase (ALP)] activity and alizarin red S staining in cultured human periosteal derived cells . Positive_regulation SLPI TNF 23657597 2819239 The functional *role* of and IL-1ß in increasing the [ALP] activity and mineralization of periosteal derived cells primarily depends on the JNK signaling among the MAPK pathways . Positive_regulation SLPI TNF 23765556 2854160 also *increased* mineralisation and the expression of bone morphogenetic protein 2 (BMP2) , [alkaline phosphatase (ALP)] , runt related transcription factor 2 ( RUNX2 ) and collagen type I ( COL I ) during this process . Positive_regulation SLPI TNF 25228904 2958346 alone *increased* both MM and [ALP] activity . Positive_regulation SLPI TNF 7946401 276752 In addition , we show that interleukin-1 beta and *induce* significant [SLPI] expression and are major inducers of elafin/pre-elafin expression . Positive_regulation SMAD1 CTGF 15855807 1425610 TGF-beta1 induced connective tissue growth factor ( ) expression in human renal proximal tubule epithelial cells *requires* Ras/MEK/ERK and [Smad] signalling . Positive_regulation SMAD1 CTGF 21541658 2531862 Furthermore , activated [TGF-ß/Smad] signaling by podocytes may *induce* and vascular endothelial growth factor overexpression , which could act as a paracrine effector mechanism on mesangial cells to stimulate mesangial matrix synthesis . Positive_regulation SMAD1 CTGF 22806900 2628864 Activated [TGF-ß/Smad] signaling by podocytes may *induce* ( CTGF or CCN2 ) and vascular endothelial growth factor ( VEGF ) expression . Positive_regulation SMAD1 CTGF 23727026 2811794 Transforming growth factor ß *induces* expression of in hepatic progenitor cells through [Smad] independent signaling . Positive_regulation SMAD1 EPHB2 10708950 673632 Our results provide evidence that *mediated* phosphorylation of [Smad1] in response to TGFbeta is critical for regulating Smad1 subcellular localization ; Positive_regulation SMAD1 EPHB2 11811554 907129 We further show that signals *enhanced* the transcriptional activity of [Smad1] in response to BMP in these cells transiently transfected with expression plasmids for a constitutively active mutant RasV12 , a dominant negative mutant RasN17 , and an ERK phosphatase CL100 . Positive_regulation SMAD1 EPHB2 12571253 1071986 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the CTGF promoter but not of a generic [Smad-responsive] promoter ( SBE-lux ) . Positive_regulation SMAD1 EPHB2 20232299 2244184 Specific inhibitors of PI3K ( 10 microM LY290042 or 10 nM wortmannin ) or ( 10 microM PD98059 ) also *blocked* GDF15 induced hypertrophy and [SMAD] activation . Positive_regulation SMAD1 EPHB2 20851880 2342788 activation *enhanced* the association of Runx2 with p300 and [Smad1] . Positive_regulation SMAD1 ID1 16247476 1518159 We show that BMP-2 *induces* expression in lung cancer cell lines through its activation of [Smad-1/5] , which is dependent on cell culture conditions . Positive_regulation SMAD1 MAP2K6 12571253 1071994 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the CTGF promoter but not of a generic [Smad-responsive] promoter ( SBE-lux ) . Positive_regulation SMAD1 NES 11509558 868498 Reporter gene activation assays demonstrated that both the NLS and are *required* for optimal transcriptional activation by [Smad1] . Positive_regulation SMAD1 PIGR 22025622 2508040 Furthermore , high expression of was *sufficient* to induce EMT through activation of [Smad] signaling . Positive_regulation SMAD1 STK39 10357889 618469 Work in mammalian tissue culture has elucidated a biochemical model for signal transduction , in which activation of receptor activity *leads* to phosphorylation of specific [Smad] proteins and translocation of heteromeric Smad protein complexes to the nucleus . Positive_regulation SMAD1 TNF 15217635 1263771 We investigated *induction* of [Smad] proteins , PPARalpha/gamma , and NF-kappaB by TNF-alpha , and hypothesized that PYY would attenuate this effect . Positive_regulation SMAD1 TNF 18567580 1946387 In the presence of the proteasome inhibitor MG132 , *increased* accumulation of ubiquitinated [Smad1] protein . Positive_regulation SMAD1 TNF 19836350 2165137 The nuclear accumulation of [Smad1] *increased* with stimulation for 30 min at Traf2 silencing . Positive_regulation SMAD1 TNF 19836350 2165138 These results suggest that the *stimulated* nuclear accumulation of [Smad1] may be dependent on Traf2 . Positive_regulation SMAD1 WIF1 21270055 2387618 Loss of [Smad1] transcriptional *activation* of was associated with reduced Wif1 expression and increased Wnt/ß-catenin signaling activity in lung epithelia , resulting in specific fetal lung abnormalities . Positive_regulation SMAD2 CLU 18082619 1854646 , a novel modulator of TGF-beta signaling , is *involved* in [Smad2/3] stability . Positive_regulation SMAD2 CLU 18082619 1854650 We also found that was *involved* in [Smad2/3] stability at the protein level . Positive_regulation SMAD2 CTGF 15855807 1425611 TGF-beta1 induced connective tissue growth factor ( ) expression in human renal proximal tubule epithelial cells *requires* Ras/MEK/ERK and [Smad] signalling . Positive_regulation SMAD2 CTGF 15950619 1421500 *enhanced* TGFbeta induced phosphorylation and nuclear translocation of [Smad 2] and Smad 3 in mesangial cells . Positive_regulation SMAD2 CTGF 21265825 2425672 Phosphorylation of [Smad-2/3] *induced* by TGF-ß1 and luciferase activity in renal tubular cells were also inhibited by honokiol . Positive_regulation SMAD2 CTGF 21541658 2531864 Furthermore , activated [TGF-ß/Smad] signaling by podocytes may *induce* and vascular endothelial growth factor overexpression , which could act as a paracrine effector mechanism on mesangial cells to stimulate mesangial matrix synthesis . Positive_regulation SMAD2 CTGF 22806900 2628866 Activated [TGF-ß/Smad] signaling by podocytes may *induce* ( CTGF or CCN2 ) and vascular endothelial growth factor ( VEGF ) expression . Positive_regulation SMAD2 CTGF 23727026 2811795 Transforming growth factor ß *induces* expression of in hepatic progenitor cells through [Smad] independent signaling . Positive_regulation SMAD2 EPHB2 12571253 1071997 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the CTGF promoter but not of a generic [Smad-responsive] promoter ( SBE-lux ) . Positive_regulation SMAD2 EPHB2 12824291 1113604 This effect was not seen in the mouse mammary epithelial NMuMG cell line , indicating that *dependent* activation of [Smad2/3] occurs only in certain cell types . Positive_regulation SMAD2 EPHB2 12824291 1113641 These results indicate that *dependent* [R-Smad] linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells . Positive_regulation SMAD2 EPHB2 15677311 1376104 Chemical inhibition of but not p38 MAPK *inhibited* TGF-beta1 induced [Smad 2] phosphorylation , and both MAPK inhibitors inhibited TGF-beta1- and H ( 2 ) O ( 2 ) -induced EMT . Positive_regulation SMAD2 EPHB2 17002919 1618163 TGF-beta activates extracellular signal regulated kinase ( ERK ) in mesangial cells , and is *involved* in activation of [Smad2/3] . Positive_regulation SMAD2 EPHB2 20232299 2244188 Specific inhibitors of PI3K ( 10 microM LY290042 or 10 nM wortmannin ) or ( 10 microM PD98059 ) also *blocked* GDF15 induced hypertrophy and [SMAD] activation . Positive_regulation SMAD2 F2R 20571025 2302888 The proteolytically inactive thrombin mimetic activating peptide also *stimulated* an increase in cytosolic [phospho-Smad2C] . Positive_regulation SMAD2 F2R 21037076 2349002 Hepatic integrin ß6 mRNA induction , expression of aVß6 protein by intrahepatic BDECs , and [SMAD2] phosphorylation were *reduced* by TF deficiency and deficiency in mice fed the ANIT diet . Positive_regulation SMAD2 HES2 20876311 2337286 ligated the transforming growth factor ( TGF ) ß receptor and *promoted* [Smad2/3] phosphorylation . Positive_regulation SMAD2 IL1B 17763417 1801837 down-regulated TGFbetaRII expression at both the protein and mRNA levels and *led* to inhibition of the TGFbeta1 induced gene expression and [Smad2/3] phosphorylation . Positive_regulation SMAD2 MAP2K6 10652224 662821 Furthermore , PD98059 , a inhibitor , *suppressed* [Smad2] phosphorylation by stimulation with anti-CD3 mAb in Jurkat T cell line . Positive_regulation SMAD2 MAP2K6 12571253 1072005 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the CTGF promoter but not of a generic [Smad-responsive] promoter ( SBE-lux ) . Positive_regulation SMAD2 MAP2K6 19413895 2120112 In addition , CREG expression blocked fibrosis and collagen synthesis through blocking *dependent* [Smad 2/3] activation in vitro and in vivo . Positive_regulation SMAD2 PIGR 22025622 2508042 Furthermore , high expression of was *sufficient* to induce EMT through activation of [Smad] signaling . Positive_regulation SMAD2 STK39 10357889 618484 Work in mammalian tissue culture has elucidated a biochemical model for signal transduction , in which activation of receptor activity *leads* to phosphorylation of specific [Smad] proteins and translocation of heteromeric Smad protein complexes to the nucleus . Positive_regulation SMAD2 TNF 15217635 1263772 We investigated *induction* of [Smad] proteins , PPARalpha/gamma , and NF-kappaB by TNF-alpha , and hypothesized that PYY would attenuate this effect . Positive_regulation SMAD3 CLU 18082619 1854647 , a novel modulator of TGF-beta signaling , is *involved* in [Smad2/3] stability . Positive_regulation SMAD3 CLU 18082619 1854651 We also found that was *involved* in [Smad2/3] stability at the protein level . Positive_regulation SMAD3 CTGF 15855807 1425612 TGF-beta1 induced connective tissue growth factor ( ) expression in human renal proximal tubule epithelial cells *requires* Ras/MEK/ERK and [Smad] signalling . Positive_regulation SMAD3 CTGF 15950619 1421501 *enhanced* TGFbeta induced phosphorylation and nuclear translocation of Smad 2 and [Smad 3] in mesangial cells . Positive_regulation SMAD3 CTGF 19641518 2185781 However , did not *stimulate* [Smad3] phosphorylation or Smad3 dependent transcriptional activity . Positive_regulation SMAD3 CTGF 20213804 2249224 *induced* phosphorylation of p38 , ERK-1/2 , JNK , and Akt , but not [Smad3] , in transgenic mouse fibroblasts compared with wild-type mouse fibroblasts . Positive_regulation SMAD3 CTGF 21265825 2425673 Phosphorylation of [Smad-2/3] *induced* by TGF-ß1 and luciferase activity in renal tubular cells were also inhibited by honokiol . Positive_regulation SMAD3 CTGF 21541658 2531866 Furthermore , activated [TGF-ß/Smad] signaling by podocytes may *induce* and vascular endothelial growth factor overexpression , which could act as a paracrine effector mechanism on mesangial cells to stimulate mesangial matrix synthesis . Positive_regulation SMAD3 CTGF 22329991 2565708 Expression of in MM cells was *induced* by the formation of a [YAP-TEAD4-Smad3-p300] complex on the CTGF promoter . Positive_regulation SMAD3 CTGF 22806900 2628868 Activated [TGF-ß/Smad] signaling by podocytes may *induce* ( CTGF or CCN2 ) and vascular endothelial growth factor ( VEGF ) expression . Positive_regulation SMAD3 CTGF 23727026 2811796 Transforming growth factor ß *induces* expression of in hepatic progenitor cells through [Smad] independent signaling . Positive_regulation SMAD3 EPHB2 11811554 907145 signals did not *augment* the transcriptional activity of [Smad3] in response to transforming growth factor beta ( TGF-beta ) receptor activation but that of Smad1 in response to BMPR activation as examined in COS-1 cells . Positive_regulation SMAD3 EPHB2 12571253 1072008 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the CTGF promoter but not of a generic [Smad-responsive] promoter ( SBE-lux ) . Positive_regulation SMAD3 EPHB2 12824291 1113605 This effect was not seen in the mouse mammary epithelial NMuMG cell line , indicating that dependent *activation* of [Smad2/3] occurs only in certain cell types . Positive_regulation SMAD3 EPHB2 12824291 1113642 These results indicate that *dependent* [R-Smad] linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells . Positive_regulation SMAD3 EPHB2 15979845 1497979 activation does not appear to be associated with nuclear translocation of Smad-3 , because ERK inhibition did not affect nuclear translocation of Smads by TGF-beta1 , and H2O2 treatment alone did not *cause* nuclear translocation of [Smad-3] . Positive_regulation SMAD3 EPHB2 17002919 1618164 TGF-beta activates extracellular signal regulated kinase ( ERK ) in mesangial cells , and is *involved* in activation of [Smad2/3] . Positive_regulation SMAD3 EPHB2 20232299 2244192 Specific inhibitors of PI3K ( 10 microM LY290042 or 10 nM wortmannin ) or ( 10 microM PD98059 ) also *blocked* GDF15 induced hypertrophy and [SMAD] activation . Positive_regulation SMAD3 EPHB2 20833210 2330854 Increased Jagged1 expression upon TGFß1 exposure required [Smad3] signalling , and was also *regulated* by PI3K and . Positive_regulation SMAD3 EPHB2 22034170 2599384 The inhibition of activity with specific inhibitors significantly *suppressed* Ox-LDL induced TGF-ß1 production , [Smad3] phosphorylation and PLTP expression . Positive_regulation SMAD3 FAS 19268879 2055623 *increased* the level of TGF-beta1 , [Smad-3] , and p21 protein in ovarian cancer cells known to be more sensitive to their inhibitory effect . Positive_regulation SMAD3 FBXO32 24002653 2856133 [Smad3] *induces* , inhibits mTOR and protein synthesis , and promotes muscle atrophy in vivo . Positive_regulation SMAD3 HES2 20876311 2337293 ligated the transforming growth factor ( TGF ) ß receptor and *promoted* [Smad2/3] phosphorylation . Positive_regulation SMAD3 IL1B 17763417 1801838 down-regulated TGFbetaRII expression at both the protein and mRNA levels and *led* to inhibition of the TGFbeta1 induced gene expression and [Smad2/3] phosphorylation . Positive_regulation SMAD3 JAG1 20833210 2330855 Increased expression upon TGFß1 exposure *required* [Smad3] signalling , and was also regulated by PI3K and ERK . Positive_regulation SMAD3 MAP2K6 12270924 1012561 Co-expression of Smad3 with constitutively active MKK3b and , the upstream activators of p38 , *resulted* in nuclear translocation of [Smad3] in the absence of TGF-beta and in induction of MMP-13 expression . Positive_regulation SMAD3 MAP2K6 12571253 1072016 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the CTGF promoter but not of a generic [Smad-responsive] promoter ( SBE-lux ) . Positive_regulation SMAD3 MAP2K6 12824291 1113613 Constitutively active ( caMEK ) *induced* alpha2 ( I ) collagen promoter activity , an effect blocked by co-transfected Smad3EPSM , but not [Smad3A] . Positive_regulation SMAD3 MAP2K6 17197157 1709400 [SMAD3] expression is *regulated* by in epithelial and smooth muscle cells . Positive_regulation SMAD3 MAP2K6 17197157 1709422 Inhibition of ( MEK1 ) with either PD98059 or UO126 , however , results in a substantial dose dependent *inhibition* of [SMAD3] promoter activity . Positive_regulation SMAD3 MAP2K6 19413895 2120120 In addition , CREG expression blocked fibrosis and collagen synthesis through blocking *dependent* [Smad 2/3] activation in vitro and in vivo . Positive_regulation SMAD3 NEDD9 15051726 1265223 Recent studies suggest that is also *involved* in the transforming growth factor-beta ( TGF-beta ) signaling pathways , by interacting with [Smad3] , a key signal transducer downstream of the TGF-beta type I receptor . Positive_regulation SMAD3 PIGR 22025622 2508044 Furthermore , high expression of was *sufficient* to induce EMT through activation of [Smad] signaling . Positive_regulation SMAD3 SPHK1 19755413 2186603 Treatment of juvenile TG mice with pitavastatin , an established inhibitor of the Rho family G proteins , or deletion of S1P3 , a major myocardial S1P receptor subtype that couples to Rho GTPases and transactivates Smad signalling , both inhibited cardiac fibrosis with concomitant inhibition of *dependent* [Smad-3] phosphorylation . Positive_regulation SMAD3 STK39 10357889 618499 Work in mammalian tissue culture has elucidated a biochemical model for signal transduction , in which activation of receptor activity *leads* to phosphorylation of specific [Smad] proteins and translocation of heteromeric Smad protein complexes to the nucleus . Positive_regulation SMAD3 STK39 15247277 1289866 Both sphingosine 1-phosphate receptors and the transforming growth factor beta-type I receptor are *essential* for activation of [Smad3] by this lysophospholipid and the dependent biological responses , indicating a novel cross-talk between serine/threonine kinase receptors and G-protein coupled receptors . Positive_regulation SMAD3 TNF 15217635 1263773 We investigated *induction* of [Smad] proteins , PPARalpha/gamma , and NF-kappaB by TNF-alpha , and hypothesized that PYY would attenuate this effect . Positive_regulation SMAD3 TNF 21893029 2486942 increased the expression of TGF-ß , and TGF-ß receptors type I and II , and also *stimulated* [Smad3] phosphorylation . Positive_regulation SMAD4 CTGF 15855807 1425613 TGF-beta1 induced connective tissue growth factor ( ) expression in human renal proximal tubule epithelial cells *requires* Ras/MEK/ERK and [Smad] signalling . Positive_regulation SMAD4 CTGF 21541658 2531868 Furthermore , activated [TGF-ß/Smad] signaling by podocytes may *induce* and vascular endothelial growth factor overexpression , which could act as a paracrine effector mechanism on mesangial cells to stimulate mesangial matrix synthesis . Positive_regulation SMAD4 CTGF 22806900 2628870 Activated [TGF-ß/Smad] signaling by podocytes may *induce* ( CTGF or CCN2 ) and vascular endothelial growth factor ( VEGF ) expression . Positive_regulation SMAD4 CTGF 23727026 2811797 Transforming growth factor ß *induces* expression of in hepatic progenitor cells through [Smad] independent signaling . Positive_regulation SMAD4 EPHB2 12571253 1072019 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the CTGF promoter but not of a generic [Smad-responsive] promoter ( SBE-lux ) . Positive_regulation SMAD4 EPHB2 12824291 1113643 These results indicate that *dependent* [R-Smad] linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells . Positive_regulation SMAD4 EPHB2 20232299 2244196 Specific inhibitors of PI3K ( 10 microM LY290042 or 10 nM wortmannin ) or ( 10 microM PD98059 ) also *blocked* GDF15 induced hypertrophy and [SMAD] activation . Positive_regulation SMAD4 MAP2K6 12571253 1072027 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the CTGF promoter but not of a generic [Smad-responsive] promoter ( SBE-lux ) . Positive_regulation SMAD4 NES 11265759 764496 We then show evidence suggesting that the *dependent* cytoplasmic localization of [Smad4] is important for ensuring optimal TGF-beta responsivenesses in transcriptional activation . Positive_regulation SMAD4 PIGR 22025622 2508046 Furthermore , high expression of was *sufficient* to induce EMT through activation of [Smad] signaling . Positive_regulation SMAD4 STK39 10357889 618514 Work in mammalian tissue culture has elucidated a biochemical model for signal transduction , in which activation of receptor activity *leads* to phosphorylation of specific [Smad] proteins and translocation of heteromeric Smad protein complexes to the nucleus . Positive_regulation SMAD4 TNF 15217635 1263774 We investigated *induction* of [Smad] proteins , PPARalpha/gamma , and NF-kappaB by TNF-alpha , and hypothesized that PYY would attenuate this effect . Positive_regulation SMAD4 TNF 19385047 2069263 We demonstrated that p300 physically associated with p65 rather than [Smad4] in the *presence* of both and TGF-beta . Positive_regulation SMAD5 CTGF 15855807 1425614 TGF-beta1 induced connective tissue growth factor ( ) expression in human renal proximal tubule epithelial cells *requires* Ras/MEK/ERK and [Smad] signalling . Positive_regulation SMAD5 CTGF 21541658 2531870 Furthermore , activated [TGF-ß/Smad] signaling by podocytes may *induce* and vascular endothelial growth factor overexpression , which could act as a paracrine effector mechanism on mesangial cells to stimulate mesangial matrix synthesis . Positive_regulation SMAD5 CTGF 22806900 2628872 Activated [TGF-ß/Smad] signaling by podocytes may *induce* ( CTGF or CCN2 ) and vascular endothelial growth factor ( VEGF ) expression . Positive_regulation SMAD5 CTGF 23727026 2811798 Transforming growth factor ß *induces* expression of in hepatic progenitor cells through [Smad] independent signaling . Positive_regulation SMAD5 EPHB2 12571253 1072030 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the CTGF promoter but not of a generic [Smad-responsive] promoter ( SBE-lux ) . Positive_regulation SMAD5 EPHB2 20232299 2244200 Specific inhibitors of PI3K ( 10 microM LY290042 or 10 nM wortmannin ) or ( 10 microM PD98059 ) also *blocked* GDF15 induced hypertrophy and [SMAD] activation . Positive_regulation SMAD5 ID1 16247476 1518161 We show that BMP-2 *induces* expression in lung cancer cell lines through its activation of [Smad-1/5] , which is dependent on cell culture conditions . Positive_regulation SMAD5 MAP2K6 12571253 1072038 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the CTGF promoter but not of a generic [Smad-responsive] promoter ( SBE-lux ) . Positive_regulation SMAD5 PIGR 22025622 2508048 Furthermore , high expression of was *sufficient* to induce EMT through activation of [Smad] signaling . Positive_regulation SMAD5 STK39 10357889 618529 Work in mammalian tissue culture has elucidated a biochemical model for signal transduction , in which activation of receptor activity *leads* to phosphorylation of specific [Smad] proteins and translocation of heteromeric Smad protein complexes to the nucleus . Positive_regulation SMAD5 TNF 15217635 1263775 We investigated *induction* of [Smad] proteins , PPARalpha/gamma , and NF-kappaB by TNF-alpha , and hypothesized that PYY would attenuate this effect . Positive_regulation SMAD6 CTGF 15855807 1425615 TGF-beta1 induced connective tissue growth factor ( ) expression in human renal proximal tubule epithelial cells *requires* Ras/MEK/ERK and [Smad] signalling . Positive_regulation SMAD6 CTGF 21541658 2531872 Furthermore , activated [TGF-ß/Smad] signaling by podocytes may *induce* and vascular endothelial growth factor overexpression , which could act as a paracrine effector mechanism on mesangial cells to stimulate mesangial matrix synthesis . Positive_regulation SMAD6 CTGF 22806900 2628874 Activated [TGF-ß/Smad] signaling by podocytes may *induce* ( CTGF or CCN2 ) and vascular endothelial growth factor ( VEGF ) expression . Positive_regulation SMAD6 CTGF 23727026 2811799 Transforming growth factor ß *induces* expression of in hepatic progenitor cells through [Smad] independent signaling . Positive_regulation SMAD6 EPHB2 12571253 1072041 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the CTGF promoter but not of a generic [Smad-responsive] promoter ( SBE-lux ) . Positive_regulation SMAD6 EPHB2 20232299 2244204 Specific inhibitors of PI3K ( 10 microM LY290042 or 10 nM wortmannin ) or ( 10 microM PD98059 ) also *blocked* GDF15 induced hypertrophy and [SMAD] activation . Positive_regulation SMAD6 ID1 23880664 2849554 It was also revealed that BMP induced Smad1/5/8 phosphorylation and expression were suppressed and inhibitory [Smad6/7] was *induced* by kisspeptin . Positive_regulation SMAD6 MAP2K6 12571253 1072049 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the CTGF promoter but not of a generic [Smad-responsive] promoter ( SBE-lux ) . Positive_regulation SMAD6 PIGR 22025622 2508050 Furthermore , high expression of was *sufficient* to induce EMT through activation of [Smad] signaling . Positive_regulation SMAD6 STK39 10357889 618544 Work in mammalian tissue culture has elucidated a biochemical model for signal transduction , in which activation of receptor activity *leads* to phosphorylation of specific [Smad] proteins and translocation of heteromeric Smad protein complexes to the nucleus . Positive_regulation SMAD6 TNF 15217635 1263776 We investigated *induction* of [Smad] proteins , PPARalpha/gamma , and NF-kappaB by TNF-alpha , and hypothesized that PYY would attenuate this effect . Positive_regulation SMAD7 ANGPT1 17085463 1685081 also reduced renal tissue levels of transforming growth factor-beta1 ( TGF-beta1 ) , alpha-smooth muscle actin , fibronectin , as well as Smad 2/3 expression , but *increased* [Smad 7] expression . Positive_regulation SMAD7 CTGF 15855807 1425616 TGF-beta1 induced connective tissue growth factor ( ) expression in human renal proximal tubule epithelial cells *requires* Ras/MEK/ERK and [Smad] signalling . Positive_regulation SMAD7 CTGF 21541658 2531874 Furthermore , activated [TGF-ß/Smad] signaling by podocytes may *induce* and vascular endothelial growth factor overexpression , which could act as a paracrine effector mechanism on mesangial cells to stimulate mesangial matrix synthesis . Positive_regulation SMAD7 CTGF 22806900 2628876 Activated [TGF-ß/Smad] signaling by podocytes may *induce* ( CTGF or CCN2 ) and vascular endothelial growth factor ( VEGF ) expression . Positive_regulation SMAD7 CTGF 23727026 2811800 Transforming growth factor ß *induces* expression of in hepatic progenitor cells through [Smad] independent signaling . Positive_regulation SMAD7 EPHB2 11716483 881690 These results indicated that activation negatively *regulated* [Smad7] transcription possibly by inhibiting translocation of Smad complex to nuclei . Positive_regulation SMAD7 EPHB2 12571253 1072052 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the CTGF promoter but not of a generic [Smad-responsive] promoter ( SBE-lux ) . Positive_regulation SMAD7 EPHB2 20232299 2244208 Specific inhibitors of PI3K ( 10 microM LY290042 or 10 nM wortmannin ) or ( 10 microM PD98059 ) also *blocked* GDF15 induced hypertrophy and [SMAD] activation . Positive_regulation SMAD7 ID1 23880664 2849557 It was also revealed that BMP induced Smad1/5/8 phosphorylation and expression were suppressed and inhibitory [Smad6/7] was *induced* by kisspeptin . Positive_regulation SMAD7 IL1B 15917296 1433610 Here , we present evidence for the existence of a direct inhibitory interaction between the IL-1beta and TGFbeta signaling cascades that is not dependent on *induced* [SMAD7] expression . Positive_regulation SMAD7 IL1B 17763417 1801839 Moreover , strongly *stimulated* the expression of inhibitory [Smad7] . Positive_regulation SMAD7 IL1B 18163503 1855444 The aim of this study was to investigate the molecular mechanism underlying the *induced* stimulation of [Smad7] in human articular chondrocytes . Positive_regulation SMAD7 IL1B 18163503 1855448 Moreover , *caused* a late induction of the inhibitory [Smad7] . Positive_regulation SMAD7 IL1B 18163503 1855449 In addition , we established , by experiments with gain/loss of function , that the *up-regulation* of [Smad7] by is mediated through the NF-kappaB pathway , especially the p65 subunit . Positive_regulation SMAD7 IL1B 18163503 1855450 Understanding the molecular basis of *induction* of [Smad7] and the reduction of chondrocyte responsiveness to TGFbeta provides new insights into the molecular mechanisms of osteoarthritis and may facilitate the identification of novel approaches for its treatment . Positive_regulation SMAD7 IL1B 21445336 2412253 In this study , we report that *induces* [Smad 7] expression by about 4.5 fold in gastric carcinoma cell line , AGS . Positive_regulation SMAD7 MAP2K6 12571253 1072060 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the CTGF promoter but not of a generic [Smad-responsive] promoter ( SBE-lux ) . Positive_regulation SMAD7 PIGR 22025622 2508052 Furthermore , high expression of was *sufficient* to induce EMT through activation of [Smad] signaling . Positive_regulation SMAD7 STK39 10357889 618559 Work in mammalian tissue culture has elucidated a biochemical model for signal transduction , in which activation of receptor activity *leads* to phosphorylation of specific [Smad] proteins and translocation of heteromeric Smad protein complexes to the nucleus . Positive_regulation SMAD7 TNF 15217635 1263777 We investigated *induction* of [Smad] proteins , PPARalpha/gamma , and NF-kappaB by TNF-alpha , and hypothesized that PYY would attenuate this effect . Positive_regulation SMAD7 TNF 16728240 1565639 [Smad7] expression in HDP cells was *increased* by , but decreased by PDTC treatment . Positive_regulation SMAD9 CTGF 15855807 1425617 TGF-beta1 induced connective tissue growth factor ( ) expression in human renal proximal tubule epithelial cells *requires* Ras/MEK/ERK and [Smad] signalling . Positive_regulation SMAD9 CTGF 21541658 2531876 Furthermore , activated [TGF-ß/Smad] signaling by podocytes may *induce* and vascular endothelial growth factor overexpression , which could act as a paracrine effector mechanism on mesangial cells to stimulate mesangial matrix synthesis . Positive_regulation SMAD9 CTGF 22806900 2628878 Activated [TGF-ß/Smad] signaling by podocytes may *induce* ( CTGF or CCN2 ) and vascular endothelial growth factor ( VEGF ) expression . Positive_regulation SMAD9 CTGF 23727026 2811801 Transforming growth factor ß *induces* expression of in hepatic progenitor cells through [Smad] independent signaling . Positive_regulation SMAD9 EPHB2 12571253 1072063 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the CTGF promoter but not of a generic [Smad-responsive] promoter ( SBE-lux ) . Positive_regulation SMAD9 EPHB2 20232299 2244212 Specific inhibitors of PI3K ( 10 microM LY290042 or 10 nM wortmannin ) or ( 10 microM PD98059 ) also *blocked* GDF15 induced hypertrophy and [SMAD] activation . Positive_regulation SMAD9 MAP2K6 12571253 1072071 Now we show that protein kinase C and are *necessary* for the TGF-beta induction of the CTGF promoter but not of a generic [Smad-responsive] promoter ( SBE-lux ) . Positive_regulation SMAD9 PIGR 22025622 2508054 Furthermore , high expression of was *sufficient* to induce EMT through activation of [Smad] signaling . Positive_regulation SMAD9 STK39 10357889 618574 Work in mammalian tissue culture has elucidated a biochemical model for signal transduction , in which activation of receptor activity *leads* to phosphorylation of specific [Smad] proteins and translocation of heteromeric Smad protein complexes to the nucleus . Positive_regulation SMAD9 TNF 15217635 1263778 We investigated *induction* of [Smad] proteins , PPARalpha/gamma , and NF-kappaB by TNF-alpha , and hypothesized that PYY would attenuate this effect . Positive_regulation SMARCA2 CCND1 21811517 2462626 Moreover , also *regulated* the expression of both [Smarca2-a] and Smarca2-b in a complex manner . Positive_regulation SMARCA2 MAP2K6 15208625 1268002 The SWI-SNF subunit [BAF60] could be phosphorylated by p38 alpha-beta in vitro , and forced activation of p38 alpha/beta in myoblasts by expression of a constitutively active ( refs. 5,6,7 ) *promoted* unscheduled SWI-SNF recruitment to the myogenin promoter . Positive_regulation SMARCA4 EPHB2 12824291 1113615 These results indicate that *dependent* [R-Smad] linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells . Positive_regulation SMARCA4 IL1B 16847181 1588105 The messenger RNA expressions of [LARC] ( liver and activation regulated chemokine ) , GMCSF ( granulocyte-macrophage colony stimulating factor ) , epiregulin , ICAM1 ( intercellular adhesion molecule 1 ) , and TGFA ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation SMARCA4 MAP2K6 15208625 1268003 The SWI-SNF subunit [BAF60] could be phosphorylated by p38 alpha-beta in vitro , and forced activation of p38 alpha/beta in myoblasts by expression of a constitutively active ( refs. 5,6,7 ) *promoted* unscheduled SWI-SNF recruitment to the myogenin promoter . Positive_regulation SMARCA4 TP63 24346698 2895199 We also show that , in epidermal progenitor cells , directly *regulates* the expression of the ATP dependent chromatin remodeller [Brg1] , which binds to distinct domains within the EDC and is required for relocation of the EDC towards the nuclear interior . Positive_regulation SMARCB1 CDKN1C 19221586 2039677 We used an inducible expression system to show that the imprinted cell cycle inhibitor is a downstream *target* for [SMARCB1] and is transcriptionally activated by increased histone H3 and H4 acetylation at the promoter . Positive_regulation SMARCB1 IL1B 16847181 1588107 The messenger RNA expressions of [LARC] ( liver and activation regulated chemokine ) , GMCSF ( granulocyte-macrophage colony stimulating factor ) , epiregulin , ICAM1 ( intercellular adhesion molecule 1 ) , and TGFA ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation SMARCB1 MAP2K6 15208625 1268004 The SWI-SNF subunit [BAF60] could be phosphorylated by p38 alpha-beta in vitro , and forced activation of p38 alpha/beta in myoblasts by expression of a constitutively active ( refs. 5,6,7 ) *promoted* unscheduled SWI-SNF recruitment to the myogenin promoter . Positive_regulation SMARCC1 EPHB2 12824291 1113616 These results indicate that *dependent* [R-Smad] linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells . Positive_regulation SMARCC1 IL1B 16847181 1588109 The messenger RNA expressions of [LARC] ( liver and activation regulated chemokine ) , GMCSF ( granulocyte-macrophage colony stimulating factor ) , epiregulin , ICAM1 ( intercellular adhesion molecule 1 ) , and TGFA ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation SMARCC1 MAP2K6 15208625 1268005 The SWI-SNF subunit [BAF60] could be phosphorylated by p38 alpha-beta in vitro , and forced activation of p38 alpha/beta in myoblasts by expression of a constitutively active ( refs. 5,6,7 ) *promoted* unscheduled SWI-SNF recruitment to the myogenin promoter . Positive_regulation SMARCC2 EPHB2 12824291 1113617 These results indicate that *dependent* [R-Smad] linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells . Positive_regulation SMARCC2 IL1B 16847181 1588111 The messenger RNA expressions of [LARC] ( liver and activation regulated chemokine ) , GMCSF ( granulocyte-macrophage colony stimulating factor ) , epiregulin , ICAM1 ( intercellular adhesion molecule 1 ) , and TGFA ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation SMARCC2 MAP2K6 15208625 1268006 The SWI-SNF subunit [BAF60] could be phosphorylated by p38 alpha-beta in vitro , and forced activation of p38 alpha/beta in myoblasts by expression of a constitutively active ( refs. 5,6,7 ) *promoted* unscheduled SWI-SNF recruitment to the myogenin promoter . Positive_regulation SMARCD1 MAP2K6 15208625 1268007 The SWI-SNF subunit [BAF60] could be phosphorylated by p38 alpha-beta in vitro , and forced activation of p38 alpha/beta in myoblasts by expression of a constitutively active ( refs. 5,6,7 ) *promoted* unscheduled SWI-SNF recruitment to the myogenin promoter . Positive_regulation SMARCD2 IL1B 16847181 1588113 The messenger RNA expressions of [LARC] ( liver and activation regulated chemokine ) , GMCSF ( granulocyte-macrophage colony stimulating factor ) , epiregulin , ICAM1 ( intercellular adhesion molecule 1 ) , and TGFA ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation SMARCE1 IL1B 16847181 1588115 The messenger RNA expressions of [LARC] ( liver and activation regulated chemokine ) , GMCSF ( granulocyte-macrophage colony stimulating factor ) , epiregulin , ICAM1 ( intercellular adhesion molecule 1 ) , and TGFA ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation SMARCE1 MAP2K6 15208625 1268008 The SWI-SNF subunit [BAF60] could be phosphorylated by p38 alpha-beta in vitro , and forced activation of p38 alpha/beta in myoblasts by expression of a constitutively active ( refs. 5,6,7 ) *promoted* unscheduled SWI-SNF recruitment to the myogenin promoter . Positive_regulation SMC2 ANGPT1 16638932 1589751 Addition of a neutralizing anti-HGF antibody inhibited *induced* [SMC] recruitment , indicating that the induction of SMC migration by Ang1 was caused by the increase of HGF . Positive_regulation SMC2 ANGPT1 16690881 1570009 Only AAV-Ang2 decreased the development of CAV , whereas *activated* arterial [SMC] and increased PDGF-A mRNA in the allograft . Positive_regulation SMC2 ANGPT1 16690881 1570025 Prolonged AAV mediated transgene expression also *induced* [SMC] activation , whereas AAV-Ang2 lacked the SMC activating effects and decreased CAV . Positive_regulation SMC2 ANGPT1 17544375 1751906 Autologous secretion of by transduced EC *resulted* in Tie-2 activation and in the presence of [SMC] expressing VEGF resulted in coordinated sprouting in vitro and increase in flow and number of arteries in vivo . Positive_regulation SMC2 ANGPT1 18556567 1946033 Interestingly , *induced* [SMC] recruitment and vessel outgrowth were severely impaired in db/db mice . Positive_regulation SMC2 CD14 7532623 292112 We thus investigated the *role* of for stimulation of vascular [SMC] by LPS . Positive_regulation SMC2 CD14 7532623 292122 Since the vascular SMC did not express endogenous CD14 , we investigated the *role* of human serum derived soluble ( sCD14 ) for activation of [SMC] by LPS . Positive_regulation SMC2 CD14 7532623 292132 These results show that specific activation of vascular [SMC] by LPS does not *involve* binding to endogenous membrane , but that the activation of vascular SMC by LPS is mediated to a great extent by serum derived sCD14 . Positive_regulation SMC2 EDN2 15695541 1388629 *increased* [ Ca ( 2+ ) ] ( i ) in acutely normoxic , but not hypoxic , DA [SMC] . Positive_regulation SMC2 EDN2 8886236 391106 A model is proposed to describe the electrical activity and intracellular calcium dynamics of vascular [smooth muscle cells (SMC)] *induced* by ( ET1 ) . Positive_regulation SMC2 IL1B 11377976 820273 *Stimulation* of [SMC] with or TNFalpha led to a time- and dose dependent increase of mRNA levels for 11beta-HSD1 , while 11beta-HSD2 mRNA levels decreased . Positive_regulation SMC2 IL1B 14732351 1199010 Treatment of *stimulated* [RA-SMC] with aminoguanidine led to an increase of 96 % in MMP-9 activity ( P = 0.003 ) by gelatin zymography , a 40 % increase in pro-MMP-9 protein ( P = 0.018 ) by Western blot , and a 155 % increase in MMP-9 mRNA ( P = 0.06 ) by reverse transcription polymerase chain reaction . Positive_regulation SMC2 IL1B 15560787 1341063 Incorporation of EPA or DHA into [SMC] , which are then *activated* by to mimic inflammation , decreases promoter activity of the cyclin D1 gene and phosphorylation of the retinoblastoma protein . Positive_regulation SMC2 IL1B 7521071 269276 The addition of cGMP derivatives modestly increased *induced* [SMC] nitrite generation without affecting the production of iNOS mRNA . Positive_regulation SMC2 IL1B 7896895 299955 Thus , our studies suggest that vascular [SMC] fibronectin synthesis is *regulated* by reciprocal induction of and TNF-alpha activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Positive_regulation SMC2 IL1B 9051715 417133 *Stimulation* of [SMC] with resulted in production of cyclooxygenase metabolites ( e.g. 6-keto-PGF1 alpha , PGE2 , PGF2 alpha , PGD2 ) , 15- , 11- , 5-HETE , and free AA1 with a coincident decline of phosphatidylcholine ( PC ) in SMC . Positive_regulation SMC2 IL1B 9051715 417138 Furthermore , TXB2 was produced in large quantities during co-incubation of *stimulated* [SMC] with human platelets for 30 min in concert with a significant decrease of 6-keto-PGF1 alpha and eicosanoids ( PGE2 , PGF2 alpha and PGD2 ) compared with control ( P < 0.01 ) . Positive_regulation SMC2 MMP28 9482695 487946 Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima , and inhibition of this *results* in reduced [SMC] migration and proliferation , suggesting a role for MMP-2 in neointimal development . Positive_regulation SMC2 MMP7 9482695 487961 Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima , and inhibition of this *results* in reduced [SMC] migration and proliferation , suggesting a role for MMP-2 in neointimal development . Positive_regulation SMC2 PECAM1 22865639 2687445 [SMC-co-culture] *increases* CD34 ( + ) ( + ) cell mobility and adhesion to and transmigration across ECs . Positive_regulation SMC2 PLAU 14718842 1197624 *induces* [SMC] proliferation and migration , which are domain dependent and mediated in part by Galphai linked , ERK dependent processes , while only the mitogenic response is protease dependent . Positive_regulation SMC2 TNF 11377976 820272 *Stimulation* of [SMC] with IL-1beta or led to a time- and dose dependent increase of mRNA levels for 11beta-HSD1 , while 11beta-HSD2 mRNA levels decreased . Positive_regulation SMC2 TNF 11750216 889858 In addition , C. pneumoniae infection enhanced the mRNA level of indoleamine 2,3-dioxygenase , an IFN-inducible factor mediating the restriction of intracellular chlamydial growth , in *stimulated* [SMC] . Positive_regulation SMC2 TNF 17414225 1722446 *Stimulation* of [SMC] with significantly increased production and secretion of such mediators of inflammation as IL-6 and MCP-1 ; Positive_regulation SMC2 TNF 20864668 2346946 *Stimulation* of the isolated intimal [smooth muscle cell (SMC)] by basic fibroblast growth factor or a resulted in increased TERT activity . Positive_regulation SMC2 TNF 7896895 299954 Thus , our studies suggest that vascular [SMC] fibronectin synthesis is *regulated* by reciprocal induction of IL-1 beta and activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Positive_regulation SMC3 ANGPT1 16638932 1589755 Addition of a neutralizing anti-HGF antibody inhibited *induced* [SMC] recruitment , indicating that the induction of SMC migration by Ang1 was caused by the increase of HGF . Positive_regulation SMC3 ANGPT1 16690881 1570013 Only AAV-Ang2 decreased the development of CAV , whereas *activated* arterial [SMC] and increased PDGF-A mRNA in the allograft . Positive_regulation SMC3 ANGPT1 16690881 1570029 Prolonged AAV mediated transgene expression also *induced* [SMC] activation , whereas AAV-Ang2 lacked the SMC activating effects and decreased CAV . Positive_regulation SMC3 ANGPT1 17544375 1751910 Autologous secretion of by transduced EC *resulted* in Tie-2 activation and in the presence of [SMC] expressing VEGF resulted in coordinated sprouting in vitro and increase in flow and number of arteries in vivo . Positive_regulation SMC3 ANGPT1 18556567 1946037 Interestingly , *induced* [SMC] recruitment and vessel outgrowth were severely impaired in db/db mice . Positive_regulation SMC3 CD14 7532623 292116 We thus investigated the *role* of for stimulation of vascular [SMC] by LPS . Positive_regulation SMC3 CD14 7532623 292126 Since the vascular SMC did not express endogenous CD14 , we investigated the *role* of human serum derived soluble ( sCD14 ) for activation of [SMC] by LPS . Positive_regulation SMC3 CD14 7532623 292136 These results show that specific activation of vascular [SMC] by LPS does not *involve* binding to endogenous membrane , but that the activation of vascular SMC by LPS is mediated to a great extent by serum derived sCD14 . Positive_regulation SMC3 EDN2 15695541 1388641 *increased* [ Ca ( 2+ ) ] ( i ) in acutely normoxic , but not hypoxic , DA [SMC] . Positive_regulation SMC3 EDN2 8886236 391118 A model is proposed to describe the electrical activity and intracellular calcium dynamics of vascular [smooth muscle cells (SMC)] *induced* by ( ET1 ) . Positive_regulation SMC3 IL1B 11377976 820281 *Stimulation* of [SMC] with or TNFalpha led to a time- and dose dependent increase of mRNA levels for 11beta-HSD1 , while 11beta-HSD2 mRNA levels decreased . Positive_regulation SMC3 IL1B 14732351 1199014 Treatment of *stimulated* [RA-SMC] with aminoguanidine led to an increase of 96 % in MMP-9 activity ( P = 0.003 ) by gelatin zymography , a 40 % increase in pro-MMP-9 protein ( P = 0.018 ) by Western blot , and a 155 % increase in MMP-9 mRNA ( P = 0.06 ) by reverse transcription polymerase chain reaction . Positive_regulation SMC3 IL1B 15560787 1341067 Incorporation of EPA or DHA into [SMC] , which are then *activated* by to mimic inflammation , decreases promoter activity of the cyclin D1 gene and phosphorylation of the retinoblastoma protein . Positive_regulation SMC3 IL1B 7521071 269280 The addition of cGMP derivatives modestly increased *induced* [SMC] nitrite generation without affecting the production of iNOS mRNA . Positive_regulation SMC3 IL1B 7896895 299963 Thus , our studies suggest that vascular [SMC] fibronectin synthesis is *regulated* by reciprocal induction of and TNF-alpha activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Positive_regulation SMC3 IL1B 9051715 417137 *Stimulation* of [SMC] with resulted in production of cyclooxygenase metabolites ( e.g. 6-keto-PGF1 alpha , PGE2 , PGF2 alpha , PGD2 ) , 15- , 11- , 5-HETE , and free AA1 with a coincident decline of phosphatidylcholine ( PC ) in SMC . Positive_regulation SMC3 IL1B 9051715 417142 Furthermore , TXB2 was produced in large quantities during co-incubation of *stimulated* [SMC] with human platelets for 30 min in concert with a significant decrease of 6-keto-PGF1 alpha and eicosanoids ( PGE2 , PGF2 alpha and PGD2 ) compared with control ( P < 0.01 ) . Positive_regulation SMC3 MMP28 9482695 488034 Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima , and inhibition of this *results* in reduced [SMC] migration and proliferation , suggesting a role for MMP-2 in neointimal development . Positive_regulation SMC3 MMP7 9482695 488049 Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima , and inhibition of this *results* in reduced [SMC] migration and proliferation , suggesting a role for MMP-2 in neointimal development . Positive_regulation SMC3 PECAM1 22865639 2687453 [SMC-co-culture] *increases* CD34 ( + ) ( + ) cell mobility and adhesion to and transmigration across ECs . Positive_regulation SMC3 PLAU 14718842 1197628 *induces* [SMC] proliferation and migration , which are domain dependent and mediated in part by Galphai linked , ERK dependent processes , while only the mitogenic response is protease dependent . Positive_regulation SMC3 TNF 11377976 820280 *Stimulation* of [SMC] with IL-1beta or led to a time- and dose dependent increase of mRNA levels for 11beta-HSD1 , while 11beta-HSD2 mRNA levels decreased . Positive_regulation SMC3 TNF 11750216 889862 In addition , C. pneumoniae infection enhanced the mRNA level of indoleamine 2,3-dioxygenase , an IFN-inducible factor mediating the restriction of intracellular chlamydial growth , in *stimulated* [SMC] . Positive_regulation SMC3 TNF 17414225 1722450 *Stimulation* of [SMC] with significantly increased production and secretion of such mediators of inflammation as IL-6 and MCP-1 ; Positive_regulation SMC3 TNF 20864668 2346954 *Stimulation* of the isolated intimal [smooth muscle cell (SMC)] by basic fibroblast growth factor or a resulted in increased TERT activity . Positive_regulation SMC3 TNF 7896895 299962 Thus , our studies suggest that vascular [SMC] fibronectin synthesis is *regulated* by reciprocal induction of IL-1 beta and activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Positive_regulation SMC4 ANGPT1 16638932 1589752 Addition of a neutralizing anti-HGF antibody inhibited *induced* [SMC] recruitment , indicating that the induction of SMC migration by Ang1 was caused by the increase of HGF . Positive_regulation SMC4 ANGPT1 16690881 1570010 Only AAV-Ang2 decreased the development of CAV , whereas *activated* arterial [SMC] and increased PDGF-A mRNA in the allograft . Positive_regulation SMC4 ANGPT1 16690881 1570026 Prolonged AAV mediated transgene expression also *induced* [SMC] activation , whereas AAV-Ang2 lacked the SMC activating effects and decreased CAV . Positive_regulation SMC4 ANGPT1 17544375 1751907 Autologous secretion of by transduced EC *resulted* in Tie-2 activation and in the presence of [SMC] expressing VEGF resulted in coordinated sprouting in vitro and increase in flow and number of arteries in vivo . Positive_regulation SMC4 ANGPT1 18556567 1946034 Interestingly , *induced* [SMC] recruitment and vessel outgrowth were severely impaired in db/db mice . Positive_regulation SMC4 CD14 7532623 292113 We thus investigated the *role* of for stimulation of vascular [SMC] by LPS . Positive_regulation SMC4 CD14 7532623 292123 Since the vascular SMC did not express endogenous CD14 , we investigated the *role* of human serum derived soluble ( sCD14 ) for activation of [SMC] by LPS . Positive_regulation SMC4 CD14 7532623 292133 These results show that specific activation of vascular [SMC] by LPS does not *involve* binding to endogenous membrane , but that the activation of vascular SMC by LPS is mediated to a great extent by serum derived sCD14 . Positive_regulation SMC4 EDN2 15695541 1388632 *increased* [ Ca ( 2+ ) ] ( i ) in acutely normoxic , but not hypoxic , DA [SMC] . Positive_regulation SMC4 EDN2 8886236 391109 A model is proposed to describe the electrical activity and intracellular calcium dynamics of vascular [smooth muscle cells (SMC)] *induced* by ( ET1 ) . Positive_regulation SMC4 IL1B 11377976 820275 *Stimulation* of [SMC] with or TNFalpha led to a time- and dose dependent increase of mRNA levels for 11beta-HSD1 , while 11beta-HSD2 mRNA levels decreased . Positive_regulation SMC4 IL1B 14732351 1199011 Treatment of *stimulated* [RA-SMC] with aminoguanidine led to an increase of 96 % in MMP-9 activity ( P = 0.003 ) by gelatin zymography , a 40 % increase in pro-MMP-9 protein ( P = 0.018 ) by Western blot , and a 155 % increase in MMP-9 mRNA ( P = 0.06 ) by reverse transcription polymerase chain reaction . Positive_regulation SMC4 IL1B 15560787 1341064 Incorporation of EPA or DHA into [SMC] , which are then *activated* by to mimic inflammation , decreases promoter activity of the cyclin D1 gene and phosphorylation of the retinoblastoma protein . Positive_regulation SMC4 IL1B 7521071 269277 The addition of cGMP derivatives modestly increased *induced* [SMC] nitrite generation without affecting the production of iNOS mRNA . Positive_regulation SMC4 IL1B 7896895 299957 Thus , our studies suggest that vascular [SMC] fibronectin synthesis is *regulated* by reciprocal induction of and TNF-alpha activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Positive_regulation SMC4 IL1B 9051715 417134 *Stimulation* of [SMC] with resulted in production of cyclooxygenase metabolites ( e.g. 6-keto-PGF1 alpha , PGE2 , PGF2 alpha , PGD2 ) , 15- , 11- , 5-HETE , and free AA1 with a coincident decline of phosphatidylcholine ( PC ) in SMC . Positive_regulation SMC4 IL1B 9051715 417139 Furthermore , TXB2 was produced in large quantities during co-incubation of *stimulated* [SMC] with human platelets for 30 min in concert with a significant decrease of 6-keto-PGF1 alpha and eicosanoids ( PGE2 , PGF2 alpha and PGD2 ) compared with control ( P < 0.01 ) . Positive_regulation SMC4 MMP28 9482695 487968 Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima , and inhibition of this *results* in reduced [SMC] migration and proliferation , suggesting a role for MMP-2 in neointimal development . Positive_regulation SMC4 MMP7 9482695 487983 Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima , and inhibition of this *results* in reduced [SMC] migration and proliferation , suggesting a role for MMP-2 in neointimal development . Positive_regulation SMC4 PECAM1 22865639 2687447 [SMC-co-culture] *increases* CD34 ( + ) ( + ) cell mobility and adhesion to and transmigration across ECs . Positive_regulation SMC4 PLAU 14718842 1197625 *induces* [SMC] proliferation and migration , which are domain dependent and mediated in part by Galphai linked , ERK dependent processes , while only the mitogenic response is protease dependent . Positive_regulation SMC4 TNF 11377976 820274 *Stimulation* of [SMC] with IL-1beta or led to a time- and dose dependent increase of mRNA levels for 11beta-HSD1 , while 11beta-HSD2 mRNA levels decreased . Positive_regulation SMC4 TNF 11750216 889859 In addition , C. pneumoniae infection enhanced the mRNA level of indoleamine 2,3-dioxygenase , an IFN-inducible factor mediating the restriction of intracellular chlamydial growth , in *stimulated* [SMC] . Positive_regulation SMC4 TNF 17414225 1722447 *Stimulation* of [SMC] with significantly increased production and secretion of such mediators of inflammation as IL-6 and MCP-1 ; Positive_regulation SMC4 TNF 20864668 2346948 *Stimulation* of the isolated intimal [smooth muscle cell (SMC)] by basic fibroblast growth factor or a resulted in increased TERT activity . Positive_regulation SMC4 TNF 7896895 299956 Thus , our studies suggest that vascular [SMC] fibronectin synthesis is *regulated* by reciprocal induction of IL-1 beta and activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Positive_regulation SMC5 ANGPT1 16638932 1589753 Addition of a neutralizing anti-HGF antibody inhibited *induced* [SMC] recruitment , indicating that the induction of SMC migration by Ang1 was caused by the increase of HGF . Positive_regulation SMC5 ANGPT1 16690881 1570011 Only AAV-Ang2 decreased the development of CAV , whereas *activated* arterial [SMC] and increased PDGF-A mRNA in the allograft . Positive_regulation SMC5 ANGPT1 16690881 1570027 Prolonged AAV mediated transgene expression also *induced* [SMC] activation , whereas AAV-Ang2 lacked the SMC activating effects and decreased CAV . Positive_regulation SMC5 ANGPT1 17544375 1751908 Autologous secretion of by transduced EC *resulted* in Tie-2 activation and in the presence of [SMC] expressing VEGF resulted in coordinated sprouting in vitro and increase in flow and number of arteries in vivo . Positive_regulation SMC5 ANGPT1 18556567 1946035 Interestingly , *induced* [SMC] recruitment and vessel outgrowth were severely impaired in db/db mice . Positive_regulation SMC5 CD14 7532623 292114 We thus investigated the *role* of for stimulation of vascular [SMC] by LPS . Positive_regulation SMC5 CD14 7532623 292124 Since the vascular SMC did not express endogenous CD14 , we investigated the *role* of human serum derived soluble ( sCD14 ) for activation of [SMC] by LPS . Positive_regulation SMC5 CD14 7532623 292134 These results show that specific activation of vascular [SMC] by LPS does not *involve* binding to endogenous membrane , but that the activation of vascular SMC by LPS is mediated to a great extent by serum derived sCD14 . Positive_regulation SMC5 EDN2 15695541 1388635 *increased* [ Ca ( 2+ ) ] ( i ) in acutely normoxic , but not hypoxic , DA [SMC] . Positive_regulation SMC5 EDN2 8886236 391112 A model is proposed to describe the electrical activity and intracellular calcium dynamics of vascular [smooth muscle cells (SMC)] *induced* by ( ET1 ) . Positive_regulation SMC5 IL1B 11377976 820277 *Stimulation* of [SMC] with or TNFalpha led to a time- and dose dependent increase of mRNA levels for 11beta-HSD1 , while 11beta-HSD2 mRNA levels decreased . Positive_regulation SMC5 IL1B 14732351 1199012 Treatment of *stimulated* [RA-SMC] with aminoguanidine led to an increase of 96 % in MMP-9 activity ( P = 0.003 ) by gelatin zymography , a 40 % increase in pro-MMP-9 protein ( P = 0.018 ) by Western blot , and a 155 % increase in MMP-9 mRNA ( P = 0.06 ) by reverse transcription polymerase chain reaction . Positive_regulation SMC5 IL1B 15560787 1341065 Incorporation of EPA or DHA into [SMC] , which are then *activated* by to mimic inflammation , decreases promoter activity of the cyclin D1 gene and phosphorylation of the retinoblastoma protein . Positive_regulation SMC5 IL1B 7521071 269278 The addition of cGMP derivatives modestly increased *induced* [SMC] nitrite generation without affecting the production of iNOS mRNA . Positive_regulation SMC5 IL1B 7896895 299959 Thus , our studies suggest that vascular [SMC] fibronectin synthesis is *regulated* by reciprocal induction of and TNF-alpha activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Positive_regulation SMC5 IL1B 9051715 417135 *Stimulation* of [SMC] with resulted in production of cyclooxygenase metabolites ( e.g. 6-keto-PGF1 alpha , PGE2 , PGF2 alpha , PGD2 ) , 15- , 11- , 5-HETE , and free AA1 with a coincident decline of phosphatidylcholine ( PC ) in SMC . Positive_regulation SMC5 IL1B 9051715 417140 Furthermore , TXB2 was produced in large quantities during co-incubation of *stimulated* [SMC] with human platelets for 30 min in concert with a significant decrease of 6-keto-PGF1 alpha and eicosanoids ( PGE2 , PGF2 alpha and PGD2 ) compared with control ( P < 0.01 ) . Positive_regulation SMC5 MMP28 9482695 487990 Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima , and inhibition of this *results* in reduced [SMC] migration and proliferation , suggesting a role for MMP-2 in neointimal development . Positive_regulation SMC5 MMP7 9482695 488005 Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima , and inhibition of this *results* in reduced [SMC] migration and proliferation , suggesting a role for MMP-2 in neointimal development . Positive_regulation SMC5 PECAM1 22865639 2687449 [SMC-co-culture] *increases* CD34 ( + ) ( + ) cell mobility and adhesion to and transmigration across ECs . Positive_regulation SMC5 PLAU 14718842 1197626 *induces* [SMC] proliferation and migration , which are domain dependent and mediated in part by Galphai linked , ERK dependent processes , while only the mitogenic response is protease dependent . Positive_regulation SMC5 TNF 11377976 820276 *Stimulation* of [SMC] with IL-1beta or led to a time- and dose dependent increase of mRNA levels for 11beta-HSD1 , while 11beta-HSD2 mRNA levels decreased . Positive_regulation SMC5 TNF 11750216 889860 In addition , C. pneumoniae infection enhanced the mRNA level of indoleamine 2,3-dioxygenase , an IFN-inducible factor mediating the restriction of intracellular chlamydial growth , in *stimulated* [SMC] . Positive_regulation SMC5 TNF 17414225 1722448 *Stimulation* of [SMC] with significantly increased production and secretion of such mediators of inflammation as IL-6 and MCP-1 ; Positive_regulation SMC5 TNF 20864668 2346950 *Stimulation* of the isolated intimal [smooth muscle cell (SMC)] by basic fibroblast growth factor or a resulted in increased TERT activity . Positive_regulation SMC5 TNF 7896895 299958 Thus , our studies suggest that vascular [SMC] fibronectin synthesis is *regulated* by reciprocal induction of IL-1 beta and activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Positive_regulation SMC6 ANGPT1 16638932 1589754 Addition of a neutralizing anti-HGF antibody inhibited *induced* [SMC] recruitment , indicating that the induction of SMC migration by Ang1 was caused by the increase of HGF . Positive_regulation SMC6 ANGPT1 16690881 1570012 Only AAV-Ang2 decreased the development of CAV , whereas *activated* arterial [SMC] and increased PDGF-A mRNA in the allograft . Positive_regulation SMC6 ANGPT1 16690881 1570028 Prolonged AAV mediated transgene expression also *induced* [SMC] activation , whereas AAV-Ang2 lacked the SMC activating effects and decreased CAV . Positive_regulation SMC6 ANGPT1 17544375 1751909 Autologous secretion of by transduced EC *resulted* in Tie-2 activation and in the presence of [SMC] expressing VEGF resulted in coordinated sprouting in vitro and increase in flow and number of arteries in vivo . Positive_regulation SMC6 ANGPT1 18556567 1946036 Interestingly , *induced* [SMC] recruitment and vessel outgrowth were severely impaired in db/db mice . Positive_regulation SMC6 CD14 7532623 292115 We thus investigated the *role* of for stimulation of vascular [SMC] by LPS . Positive_regulation SMC6 CD14 7532623 292125 Since the vascular SMC did not express endogenous CD14 , we investigated the *role* of human serum derived soluble ( sCD14 ) for activation of [SMC] by LPS . Positive_regulation SMC6 CD14 7532623 292135 These results show that specific activation of vascular [SMC] by LPS does not *involve* binding to endogenous membrane , but that the activation of vascular SMC by LPS is mediated to a great extent by serum derived sCD14 . Positive_regulation SMC6 EDN2 15695541 1388638 *increased* [ Ca ( 2+ ) ] ( i ) in acutely normoxic , but not hypoxic , DA [SMC] . Positive_regulation SMC6 EDN2 8886236 391115 A model is proposed to describe the electrical activity and intracellular calcium dynamics of vascular [smooth muscle cells (SMC)] *induced* by ( ET1 ) . Positive_regulation SMC6 IL1B 11377976 820279 *Stimulation* of [SMC] with or TNFalpha led to a time- and dose dependent increase of mRNA levels for 11beta-HSD1 , while 11beta-HSD2 mRNA levels decreased . Positive_regulation SMC6 IL1B 14732351 1199013 Treatment of *stimulated* [RA-SMC] with aminoguanidine led to an increase of 96 % in MMP-9 activity ( P = 0.003 ) by gelatin zymography , a 40 % increase in pro-MMP-9 protein ( P = 0.018 ) by Western blot , and a 155 % increase in MMP-9 mRNA ( P = 0.06 ) by reverse transcription polymerase chain reaction . Positive_regulation SMC6 IL1B 15560787 1341066 Incorporation of EPA or DHA into [SMC] , which are then *activated* by to mimic inflammation , decreases promoter activity of the cyclin D1 gene and phosphorylation of the retinoblastoma protein . Positive_regulation SMC6 IL1B 19374865 2065503 We show that PPAR activators , as well as liver X receptor alpha , farnesoid X receptor and retinoid X receptor alpha activators , inhibit *induced* [SMC 6-keto] PGF1alpha synthesis , an index of cyclooxygenase (COX)-2 activity , with IC ( 50 ) between 1 and 69 microM . Positive_regulation SMC6 IL1B 7521071 269279 The addition of cGMP derivatives modestly increased *induced* [SMC] nitrite generation without affecting the production of iNOS mRNA . Positive_regulation SMC6 IL1B 7896895 299961 Thus , our studies suggest that vascular [SMC] fibronectin synthesis is *regulated* by reciprocal induction of and TNF-alpha activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Positive_regulation SMC6 IL1B 9051715 417136 *Stimulation* of [SMC] with resulted in production of cyclooxygenase metabolites ( e.g. 6-keto-PGF1 alpha , PGE2 , PGF2 alpha , PGD2 ) , 15- , 11- , 5-HETE , and free AA1 with a coincident decline of phosphatidylcholine ( PC ) in SMC . Positive_regulation SMC6 IL1B 9051715 417141 Furthermore , TXB2 was produced in large quantities during co-incubation of *stimulated* [SMC] with human platelets for 30 min in concert with a significant decrease of 6-keto-PGF1 alpha and eicosanoids ( PGE2 , PGF2 alpha and PGD2 ) compared with control ( P < 0.01 ) . Positive_regulation SMC6 MMP28 9482695 488012 Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima , and inhibition of this *results* in reduced [SMC] migration and proliferation , suggesting a role for MMP-2 in neointimal development . Positive_regulation SMC6 MMP7 9482695 488027 Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima , and inhibition of this *results* in reduced [SMC] migration and proliferation , suggesting a role for MMP-2 in neointimal development . Positive_regulation SMC6 PECAM1 22865639 2687451 [SMC-co-culture] *increases* CD34 ( + ) ( + ) cell mobility and adhesion to and transmigration across ECs . Positive_regulation SMC6 PLAU 14718842 1197627 *induces* [SMC] proliferation and migration , which are domain dependent and mediated in part by Galphai linked , ERK dependent processes , while only the mitogenic response is protease dependent . Positive_regulation SMC6 TNF 11377976 820278 *Stimulation* of [SMC] with IL-1beta or led to a time- and dose dependent increase of mRNA levels for 11beta-HSD1 , while 11beta-HSD2 mRNA levels decreased . Positive_regulation SMC6 TNF 11750216 889861 In addition , C. pneumoniae infection enhanced the mRNA level of indoleamine 2,3-dioxygenase , an IFN-inducible factor mediating the restriction of intracellular chlamydial growth , in *stimulated* [SMC] . Positive_regulation SMC6 TNF 17414225 1722449 *Stimulation* of [SMC] with significantly increased production and secretion of such mediators of inflammation as IL-6 and MCP-1 ; Positive_regulation SMC6 TNF 20864668 2346952 *Stimulation* of the isolated intimal [smooth muscle cell (SMC)] by basic fibroblast growth factor or a resulted in increased TERT activity . Positive_regulation SMC6 TNF 7896895 299960 Thus , our studies suggest that vascular [SMC] fibronectin synthesis is *regulated* by reciprocal induction of IL-1 beta and activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Positive_regulation SMN1 CTGF 21645240 2579213 In tibialis anterior muscle overexpressing CTGF using an adenovirus , ARB treatment decreased *mediated* increase of ECM molecules , [a-SMA] and ERK-1/2 phosphorylation levels . Positive_regulation SMN1 CTGF 22542845 2602928 *induces* TM fibronectin and [a-SMA] in animals , whereas actin stress fibers and contractility are both induced in cultured TM cells . Positive_regulation SMN1 CTGF 23525012 2794301 Both adenoviral expression of in epithelial cells and treatment with recombinant CTGF *induced* EMT-like morphological changes and expression of [a-SMA] . Positive_regulation SMN1 CTGF 24049536 2842897 When cells were treated with PTH ( 0.1 nM ) for 48 h , [a-SMA] protein expression was induced significantly , the protein expression of E-cadherin decreased substantially , and the promoter activity of the gene as well as its mRNA and protein expression levels *increased* ( p < 0.01 ) . Positive_regulation SMN1 CTGF 24392320 2883987 TGF-ß2 and could *induce* HLECs to express [a-SMA] , Fn and Col-1 in time dependent manner . Positive_regulation SMN1 CTGF 24486572 2923622 These results suggest that ET-1 stimulates expressions of CTGF and a-SMA through ETAR/JNK/AP-1 signaling pathway , and is *required* for ET-1 induced [a-SMA] expression in human lung fibroblasts . Positive_regulation SMN1 EPHB2 16598650 1544942 The induction of [alpha-SMA] by TGF-beta1 was *suppressed* by p38 kinase inhibitor ( SB203580 ) and inhibitor ( PD98059 ) . Positive_regulation SMN1 EPHB2 18669633 1967362 Although both and p38 MAPK activation is *required* for maximal TGF-beta1 induced [alpha-SMA] expression , ERK is the major signaling intermediate in cells that express FAK . Positive_regulation SMN1 EPHB2 22116522 2591725 In the mean time , reducing Erbin expression enhanced phosphorylation , promoted the E-cadherin suppression , and *induced* [a-SMA] expression and fibronection secretion in response to TGF-ß1 , which could be rescued if cells were treated with the inhibitor of MEK1/2 U0126 . Positive_regulation SMN1 EPHB2 22126761 2514780 In the presence of TGF-ß ( 1 ) , blocking of Smads , , and p38MAPK pathways , but not JNK/MAPK pathway , *caused* an obvious decrease in [a-SMA] levels in the fibroblasts in both groups . Positive_regulation SMN1 HBEGF 9697669 524690 Because tubular cells expressing high levels of HB-EGF mRNA were directly apposed to myofibroblasts , an attempt was made to determine whether *contributed* to upregulation of [alpha-SMA] by human fibroblasts . Positive_regulation SMN1 IL1B 12921636 1130983 SB203580 uppercased the *induced* expression of [alpha-SMA] and the enhancement of cell migration ability were suppressed by 51 % ( P < 0.05 ) . Positive_regulation SMN1 IL1B 15665553 1375926 To understand the signal transduction mechanisms involved in transdifferentiation , we examined the roles of mitogen activated protein kinases ( MAPKs ) in *stimulated* [alpha-SMA] expression and cell migration in the HK-2 human renal proximal tubular cell line . Positive_regulation SMN1 IL1B 15665553 1375927 Both SP600125 , a specific inhibitor of JNK , and SB203580 , a specific inhibitor of p38 MAPK , suppressed the *induced* expression of [alpha-SMA] and cell migration , but these effects were not observed with PD98059 , a specific inhibitor of ERK . Positive_regulation SMN1 MAP2K6 18936144 2021502 TGFbeta1 induced [alpha-SMA] expression was *reduced* by inhibition ( U0126 ) ; Positive_regulation SMN1 PLAT 18037995 1832670 ( tPA ) *promoted* TGF-beta1 mediated [alpha-SMA] and type I collagen expression in rat kidney interstitial fibroblasts . Positive_regulation SMN1 PLAU 15268802 1276038 In grade 3 and 4 , the plasma levels of TGFbeta and the protein expression of [a-SMA] and PAI-1 in fibrotic liver tissue were significantly increased , but the protein expression of in cirrhosis liver tissue did not *increased* . Positive_regulation SMN1 SMN2 10196366 604670 [SMA] is *caused* by alterations of the gene which encodes a novel protein of hitherto unclear function . Positive_regulation SMN1 SMN2 10655541 663894 These results show that [SMA] is *caused* by insufficient production by the SMN2 gene and that increased expression of the SMN2 gene may provide a strategy for treating SMA patients . Positive_regulation SMN1 SMN2 11914277 925126 Reduction in protein *results* in [Spinal muscular atrophy (SMA)] , a common neurodegenerative disease . Positive_regulation SMN1 SMN2 12952942 1137487 [SMA] is *caused* by low levels of the ubiquitously expressed . Positive_regulation SMN1 SMN2 15523494 1359887 [Spinal muscular atrophy (SMA)] is *caused* by insufficient levels of . Positive_regulation SMN1 SMN2 15975577 1446334 [Spinal muscular atrophy (SMA)] is *caused* by reduced levels of ( survival of motor neurons protein ) and consequent loss of motor neurons . Positive_regulation SMN1 SMN2 18093976 1868977 [Spinal muscular atrophy (SMA)] is *caused* by reduced levels of the protein . Positive_regulation SMN1 SMN2 18603534 1953987 [Spinal muscular atrophy (SMA)] is *caused* by reduced levels of . Positive_regulation SMN1 SMN2 19897588 2188817 [SMA] is a *consequence* of low levels of . Positive_regulation SMN1 SMN2 20085811 2218881 [Spinal muscular atrophy (SMA)] is *caused* by insufficient levels of the leading to muscle paralysis and respiratory failure . Positive_regulation SMN1 SMN2 20089893 2201315 Low levels of *result* in [spinal muscular atrophy (SMA)] , a severe genetic disease characterized by motor impairment and premature lethality . Positive_regulation SMN1 SMN2 20523126 2345334 Thus is a prime therapeutic *target* for [SMA] . Positive_regulation SMN1 SMN2 20705736 2330107 Reduced expression of the gene *causes* the childhood motor neuron disease [spinal muscular atrophy (SMA)] . Positive_regulation SMN1 SMN2 21249120 2359707 [Spinal muscular atrophy (SMA)] is *caused* by low levels and patients represent a clinical spectrum due primarily to varying copies of the survival motor neuron-2 (SMN2) gene . Positive_regulation SMN1 SMN2 21389246 2400529 [Spinal muscular atrophy (SMA)] *results* from reduced levels of the protein , which has a well characterized function in spliceosomal small nuclear ribonucleoprotein assembly . Positive_regulation SMN1 SMN2 21538807 2509798 Proximal [spinal muscular atrophy (SMA)] is *caused* by low levels of the protein , encoded by the Survival Motor Neuron genes ( SMN1 and SMN2 ) . Positive_regulation SMN1 SMN2 21920940 2506867 [Spinal muscular atrophy (SMA)] , a frequent neurodegenerative disease , is *caused* by reduced levels of functional protein . Positive_regulation SMN1 SMN2 22186025 2563498 [SMA] *results* from deletion or mutation of the Survival Motor Neuron 1 gene (SMN1) and retention of . Positive_regulation SMN1 SMN2 22324632 2576118 At present , the *role* of in [SMA] is unknown . Positive_regulation SMN1 SMN2 22669476 2686846 [SMA] is *caused* by low levels of that induce selective loss of a-motor neurons (MNs) in the spinal cord , resulting in progressive muscle atrophy and consequent respiratory failure . Positive_regulation SMN1 SMN2 22723710 2616692 The inherited motor neuron disease [spinal muscular atrophy (SMA)] is *caused* by deficient expression of and results in severe muscle weakness . Positive_regulation SMN1 SMN2 23022481 2689596 Decreased expression of *causes* the fatal childhood motor neuron disorder [spinal muscular atrophy (SMA)] . Positive_regulation SMN1 SMN2 23575853 2768297 [Spinal muscular atrophy (SMA)] , a recessive neuromuscular disorder , is *caused* by diminished function of the . Positive_regulation SMN1 SMN2 23727836 2843803 [Spinal muscular atrophy (SMA)] is *caused* by mutations of the survival motor neuron 1 (SMN1) gene , retention of the survival motor neuron 2 (SMN2) gene and insufficient expression of full-length . Positive_regulation SMN1 SMN2 23736298 2843833 [Spinal muscular atrophy (SMA)] is *caused* by insufficient levels of the due to the functional loss of the SMN1 gene and the inability of its paralog , SMN2 , to fully compensate due to reduced exon 7 splicing efficiency . Positive_regulation SMN1 SMN2 9811937 545964 While our data do not help decide whether [SMA] *results* from impaired expression in spinal cord , skeletal muscle or both , they suggest a requirement for SMN protein during embryo-fetal development . Positive_regulation SMN1 TNNT2 18312428 1879141 Anti-FGF8b antibody inhibited the expression of SMA , , and Tbx5 , which are BMP independent heart mesoderm/early cardiomyocyte genes , but not Brachyury in cultured posterior blastoderm , and combined FGF8b and Nodal , but neither factor alone *induced* the expression of [SMA] in association with heart specific markers in cultured epiblast . Positive_regulation SMN2 BCL10 22732506 2639123 Here we demonstrate that expression *increases* [SMN] protein by ~2-fold in SH-SY5Y cells . Positive_regulation SMN2 BCL2 22732506 2639124 Here we demonstrate that expression *increases* [SMN] protein by ~2-fold in SH-SY5Y cells . Positive_regulation SMN2 BCL3 22732506 2639125 Here we demonstrate that expression *increases* [SMN] protein by ~2-fold in SH-SY5Y cells . Positive_regulation SMN2 BCL5 22732506 2639120 Here we demonstrate that expression *increases* [SMN] protein by ~2-fold in SH-SY5Y cells . Positive_regulation SMN2 BCL6 22732506 2639121 Here we demonstrate that expression *increases* [SMN] protein by ~2-fold in SH-SY5Y cells . Positive_regulation SMN2 BCL9 22732506 2639122 Here we demonstrate that expression *increases* [SMN] protein by ~2-fold in SH-SY5Y cells . Positive_regulation SMN2 CLNS1A 11756452 916260 The functions to modify specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins , and this modification *targets* these proteins to the [survival of motor neurons (SMN)] complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles . Positive_regulation SMN2 COIL 19997741 2217416 phosphorylation *mediates* interaction with [SMN] and SmB ' . Positive_regulation SMN2 CREB1 14742439 1226165 Transient overexpression of protein *resulted* in a 4-fold increase of the [SMN] promoter activity . Positive_regulation SMN2 DDX20 10500148 648015 Moreover , we show that [SMN] , but not mutants found in SMA patients , can form large oligomers and that oligomerization is *required* for high-affinity binding to spliceosomal snRNP Sm proteins . Positive_regulation SMN2 DDX20 10767334 684881 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Positive_regulation SMN2 DDX20 10901626 712796 Immunolocalization studies using SMN monoclonal antibody showed that [SMN] is decreased in cultures grown in low K+ or chemically defined medium with respect to cultures grown in high K+ medium and that an increase of can be *induced* by treatment of low K+ cultures with glutamate or N-methyl-D-aspartate . Positive_regulation SMN2 DDX20 16554261 1538068 [SMN2] produces reduced amounts of full-length SMN mRNA , and spinal muscular atrophy likely *results* from insufficient levels of protein in motor neurons . Positive_regulation SMN2 DHX9 11149922 780479 In vitro experiments suggest that *mediates* the association of [SMN] with the COOH-terminal domain of pol II . Positive_regulation SMN2 FUS 23022481 2689640 Here , we report that FUS associates with the [SMN complex] , *mediated* by U1 snRNP and by direct interactions between and SMN . Positive_regulation SMN2 GEMIN2 10500148 648009 Moreover , we show that [SMN] , but not mutants found in SMA patients , can form large oligomers and that oligomerization is *required* for high-affinity binding to spliceosomal snRNP Sm proteins . Positive_regulation SMN2 GEMIN2 10767334 684873 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Positive_regulation SMN2 GEMIN2 10901626 712788 Immunolocalization studies using SMN monoclonal antibody showed that [SMN] is decreased in cultures grown in low K+ or chemically defined medium with respect to cultures grown in high K+ medium and that an increase of can be *induced* by treatment of low K+ cultures with glutamate or N-methyl-D-aspartate . Positive_regulation SMN2 GEMIN2 16554261 1538062 [SMN2] produces reduced amounts of full-length SMN mRNA , and spinal muscular atrophy likely *results* from insufficient levels of protein in motor neurons . Positive_regulation SMN2 GEMIN4 10500148 648011 Moreover , we show that [SMN] , but not mutants found in SMA patients , can form large oligomers and that oligomerization is *required* for high-affinity binding to spliceosomal snRNP Sm proteins . Positive_regulation SMN2 GEMIN4 10767334 684877 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Positive_regulation SMN2 GEMIN4 10901626 712792 Immunolocalization studies using SMN monoclonal antibody showed that [SMN] is decreased in cultures grown in low K+ or chemically defined medium with respect to cultures grown in high K+ medium and that an increase of can be *induced* by treatment of low K+ cultures with glutamate or N-methyl-D-aspartate . Positive_regulation SMN2 GEMIN4 16554261 1538064 [SMN2] produces reduced amounts of full-length SMN mRNA , and spinal muscular atrophy likely *results* from insufficient levels of protein in motor neurons . Positive_regulation SMN2 GEMIN5 10500148 648012 Moreover , we show that [SMN] , but not mutants found in SMA patients , can form large oligomers and that oligomerization is *required* for high-affinity binding to spliceosomal snRNP Sm proteins . Positive_regulation SMN2 GEMIN5 10767334 684878 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Positive_regulation SMN2 GEMIN5 10901626 712793 Immunolocalization studies using SMN monoclonal antibody showed that is decreased in cultures grown in low K+ or chemically defined medium with respect to cultures grown in high K+ medium and that an increase of [SMN] can be *induced* by treatment of low K+ cultures with glutamate or N-methyl-D-aspartate . Positive_regulation SMN2 GEMIN5 16554261 1538065 [SMN2] produces reduced amounts of full-length SMN mRNA , and spinal muscular atrophy likely *results* from insufficient levels of protein in motor neurons . Positive_regulation SMN2 GEMIN6 10500148 648013 Moreover , we show that [SMN] , but not mutants found in SMA patients , can form large oligomers and that oligomerization is *required* for high-affinity binding to spliceosomal snRNP Sm proteins . Positive_regulation SMN2 GEMIN6 10767334 684879 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Positive_regulation SMN2 GEMIN6 10901626 712794 Immunolocalization studies using SMN monoclonal antibody showed that [SMN] is decreased in cultures grown in low K+ or chemically defined medium with respect to cultures grown in high K+ medium and that an increase of can be *induced* by treatment of low K+ cultures with glutamate or N-methyl-D-aspartate . Positive_regulation SMN2 GEMIN6 16554261 1538066 [SMN2] produces reduced amounts of full-length SMN mRNA , and spinal muscular atrophy likely *results* from insufficient levels of protein in motor neurons . Positive_regulation SMN2 GEMIN7 10500148 648014 Moreover , we show that [SMN] , but not mutants found in SMA patients , can form large oligomers and that oligomerization is *required* for high-affinity binding to spliceosomal snRNP Sm proteins . Positive_regulation SMN2 GEMIN7 10767334 684880 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Positive_regulation SMN2 GEMIN7 10901626 712795 Immunolocalization studies using SMN monoclonal antibody showed that is decreased in cultures grown in low K+ or chemically defined medium with respect to cultures grown in high K+ medium and that an increase of [SMN] can be *induced* by treatment of low K+ cultures with glutamate or N-methyl-D-aspartate . Positive_regulation SMN2 GEMIN7 16554261 1538067 [SMN2] produces reduced amounts of full-length SMN mRNA , and spinal muscular atrophy likely *results* from insufficient levels of protein in motor neurons . Positive_regulation SMN2 GEMIN8 17023415 1647848 We show that Gemin6 , Gemin7 , and Unrip form a stable cytoplasmic complex whose association with [SMN] *requires* . Positive_regulation SMN2 IFNB1 11147573 760972 Here we show that both and IFN-gamma rapidly *induced* [SMN] and SMNc mRNA and protein expression in various cell lines . Positive_regulation SMN2 IFNG 11147573 760973 Here we show that both IFN-beta and rapidly *induced* [SMN] and SMNc mRNA and protein expression in various cell lines . Positive_regulation SMN2 LBH 19584083 2129333 *induces* up to 10-fold [SMN] protein levels by several independent mechanisms and is effective even in cells from SMA patients non-responsive to valproate . Positive_regulation SMN2 LBH 19584083 2129365 treatment of human SMA fibroblasts *induced* up to 10-fold elevated [SMN] levels , the highest ever reported , accompanied by a markedly increased number of gems . Positive_regulation SMN2 LBH 19584083 2129372 Furthermore , *stabilizes* [SMN] by reducing its ubiquitinylation as well as favouring incorporation into the SMN complex . Positive_regulation SMN2 LBH 19584083 2129381 Notably , also *induces* [SMN2] expression in SMA fibroblasts inert to VPA , in human neural stem cells and in the spinal cord of SMN2-transgenic mice . Positive_regulation SMN2 NPY4R 22454514 2637032 A *role* for protein phosphatase in [SMN complex] formation and subnuclear localization to Cajal bodies . Positive_regulation SMN2 NPY4R 22454514 2637089 Our findings reveal a *role* of in the formation of the [SMN complex] and the maintenance of CB integrity . Positive_regulation SMN2 PIEZO1 23615451 2800237 Knocking down levels *increases* [SMN] protein levels in cultured cells . Positive_regulation SMN2 PRMT5 11756452 916259 The functions to modify specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins , and this modification *targets* these proteins to the [survival of motor neurons (SMN)] complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles . Positive_regulation SMN2 PRNP 18178576 1889958 The *results* in high levels of [SMN] in neurons at embryonic day 15 . Positive_regulation SMN2 RB1 22415578 2681279 The most common SMN in the osteosarcoma group was breast cancer ( n = 11 ) , and the most common [SMN] in the Ewing sarcoma group was radiotherapy *induced* ( n = 6 ) . Positive_regulation SMN2 SMN1 19945425 2198953 is the *result* of reduction in [Survival Motor Neuron (SMN)] expression . Positive_regulation SMN2 SMN1 21925145 2492104 The close relationship to *results* in [SMN2] being a very power genetic modifier of SMA disease severity and a target for therapies . Positive_regulation SMN2 SMN2 10369862 621808 In SMA patients , the loss of SMN1 but the presence of *results* in low levels of full-length [SMN] transcript and therefore low SMN protein levels which causes SMA . Positive_regulation SMN2 SMN2 10500148 648010 Moreover , we show that [SMN] , but not mutants found in SMA patients , can form large oligomers and that oligomerization is *required* for high-affinity binding to spliceosomal snRNP Sm proteins . Positive_regulation SMN2 SMN2 10767334 684874 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Positive_regulation SMN2 SMN2 10901626 712789 Immunolocalization studies using SMN monoclonal antibody showed that is decreased in cultures grown in low K+ or chemically defined medium with respect to cultures grown in high K+ medium and that an increase of [SMN] can be *induced* by treatment of low K+ cultures with glutamate or N-methyl-D-aspartate . Positive_regulation SMN2 SMN2 16554261 1538063 [SMN2] produces reduced amounts of full-length SMN mRNA , and spinal muscular atrophy likely *results* from insufficient levels of protein in motor neurons . Positive_regulation SMN2 SNRNP70 23022481 2689637 Here , we report that FUS associates with the [SMN complex] , *mediated* by and by direct interactions between FUS and SMN . Positive_regulation SMN2 SNRPA 10767334 684875 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Positive_regulation SMN2 SNRPA 10901626 712790 Immunolocalization studies using SMN monoclonal antibody showed that [SMN] is decreased in cultures grown in low K+ or chemically defined medium with respect to cultures grown in high K+ medium and that an increase of can be *induced* by treatment of low K+ cultures with glutamate or N-methyl-D-aspartate . Positive_regulation SMN2 SNRPA 23022481 2689638 Here , we report that FUS associates with the [SMN complex] , *mediated* by and by direct interactions between FUS and SMN . Positive_regulation SMN2 SNRPB 10767334 684876 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Positive_regulation SMN2 SNRPB 10901626 712791 Immunolocalization studies using SMN monoclonal antibody showed that [SMN] is decreased in cultures grown in low K+ or chemically defined medium with respect to cultures grown in high K+ medium and that an increase of can be *induced* by treatment of low K+ cultures with glutamate or N-methyl-D-aspartate . Positive_regulation SMN2 SNRPC 23022481 2689639 Here , we report that FUS associates with the [SMN complex] , *mediated* by and by direct interactions between FUS and SMN . Positive_regulation SMN2 STAT5A 17220171 1709738 We found that activation *enhanced* [SMN2] promoter activity with increase in both full-length and deletion exon 7 SMN transcripts in SMN2-NSC34 cells . Positive_regulation SMN2 STAT5A 17220171 1709739 Knockdown of Stat5 expression disrupted the effects of sodium vanadate on SMN2 activation but did not influence SMN2 splicing , suggesting that signaling is *involved* in [SMN2] transcriptional regulation . Positive_regulation SMN2 STRAP 10767334 684882 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Positive_regulation SMN2 STRAP 10901626 712797 Immunolocalization studies using SMN monoclonal antibody showed that [SMN] is decreased in cultures grown in low K+ or chemically defined medium with respect to cultures grown in high K+ medium and that an increase of can be *induced* by treatment of low K+ cultures with glutamate or N-methyl-D-aspartate . Positive_regulation SMN2 TAF1A 11867547 918008 The is necessary and *sufficient* for [SMN complex] binding in vivo and in vitro . Positive_regulation SMN2 TAF1B 11867547 918009 The is necessary and *sufficient* for [SMN complex] binding in vivo and in vitro . Positive_regulation SMN2 TAF1C 11867547 918010 The is necessary and *sufficient* for [SMN complex] binding in vivo and in vitro . Positive_regulation SMN2 TRA2B 10931943 722536 1 stimulates an exonic splicing enhancer and can *restore* full-length [SMN] expression to survival motor neuron 2 (SMN2) . Positive_regulation SMN2 TRA2B 10931943 722545 This effect is not species-specific as expression of in human or mouse cells carrying an SMN2 minigene dramatically *increased* production of full-length [SMN2] . Positive_regulation SMN2 TRA2B 12915451 1135259 Importantly , this up-regulation of SMN could be most likely attributed to increased levels of 1 which facilitates the correct splicing of SMN2 RNA as well as to an [SMN] gene transcription *activation* . Positive_regulation SMN2 TRA2B 20190275 2248797 We have shown earlier that binds SMN1/SMN2 RNA and *restores* full-length ( FL ) [-SMN2] mRNA levels in vitro . Positive_regulation SMN2 WDR77 11756452 916261 The functions to modify specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins , and this modification *targets* these proteins to the [survival of motor neurons (SMN)] complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles . Positive_regulation SMN2 WRAP53 21072240 2345083 is *essential* for Cajal body formation and for targeting the [survival of motor neuron] complex to Cajal bodies . Positive_regulation SMN2 WRAP53 21072240 2345092 Furthermore , depletion of leads to accumulation of SMN in the cytoplasm and *prevents* the [SMN complex] from reaching Cajal bodies . Positive_regulation SMN2 WRAP53 21072240 2345097 This suggests that loss of *mediated* [SMN] trafficking contributes to spinal muscular atrophy . Positive_regulation SMN2 ZNF259 11283611 799467 Our data show that is *required* for the localization of [SMN] in nuclear bodies . Positive_regulation SMO TNF 17145855 1653897 Inhibition of *induced* [SMO/PAOh1] activity with MDL 72,527 or with a targeted siRNA prevented ROS production and oxidative DNA damage . Positive_regulation SMOX TNF 17145855 1653898 Inhibition of *induced* [SMO/PAOh1] activity with MDL 72,527 or with a targeted siRNA prevented ROS production and oxidative DNA damage . Positive_regulation SMPD1 FAS 11255263 794231 receptor and tumor necrosis factor receptor-1 (TNFR1) *mediate* the activation of [acid sphingomyelinase (ASMase)] , which catalyzes the hydrolysis of sphingomyelin to ceramide . Positive_regulation SMPD1 FAS 8846779 338007 Activation of a phosphatidylcholine-specific phospholipase C ( PC-PLC ) was also detected which appeared to be a requirement for subsequent acidic sphingomyelinase (aSMase) activation , since PC-PLC inhibitor D609 blocked *induced* [aSMase] activation , but not Fas/APO-1 induced neutral sphingomyelinase (nSMase) activation . Positive_regulation SMPD1 TNF 10026132 591206 Requirement of FADD for *induced* activation of [acid sphingomyelinase] . Positive_regulation SMPD1 TNF 10026132 591207 In this report we demonstrate the requirement of FADD for *induced* activation of endosomal [acid sphingomyelinase (A-SMase)] . Positive_regulation SMPD1 TNF 14739942 1235039 Cathepsin D links *induced* [acid sphingomyelinase] to Bid mediated caspase-9 and -3 activation . Positive_regulation SMPD1 TNF 16033420 1436113 Abeta , , or the combination of both , *increased* neutral sphingomyelinase (nSMase) activity , but not [acidic sphingomyelinase (aSMase)] activity , leading to ceramide accumulation . Positive_regulation SMPD2 FAS 14871831 1208284 A caspase-3 inhibitor , acetyl-Asp-Glu-Val-Asp-chloromethyl ketone , blocked not only *induced* increases of apoptosis and ceramide content but also Fas induced activation of [nSMase] and inhibition of SM synthase in the nuclear fraction . Positive_regulation SMPD2 FAS 8846779 338008 Activation of a phosphatidylcholine-specific phospholipase C ( PC-PLC ) was also detected which appeared to be a requirement for subsequent acidic sphingomyelinase (aSMase) activation , since PC-PLC inhibitor D609 blocked induced aSMase activation , but not Fas/APO-1 induced [neutral sphingomyelinase (nSMase)] *activation* . Positive_regulation SMPD2 IL1B 10704249 672792 *Activation* of [neutral sphingomyelinase] by requires the type 1 interleukin 1 receptor . Positive_regulation SMPD2 IL1B 10704249 672802 The cytokine interleukin 1beta (IL-1beta) plays an important role in host defence reactions and neuro-immune interactions but it is still not clear which of the two interleukin 1 receptor subtypes is coupled to *activation* of [neutral sphingomyelinase (nSMase)] by . Positive_regulation SMPD2 IL1B 10704249 672805 In the presence of an IL-1 receptor antagonist (IL-1ra) , did not *activate* [nSMase] either in the cortex of wild-type or knock-out mice . Positive_regulation SMPD2 IL1B 10808527 692490 The was shown to *activate* in a dose dependent manner [nSMase] in the P2 fraction of the brain cortex . Positive_regulation SMPD2 IL1B 11457826 860134 Short-term stimulation of mesangial cells with the pro-inflammatory cytokine *leads* to a rapid and transient increase in [neutral sphingomyelinase] activity ( Kaszkin , M. , Huwiler , A. , Scholz , K. , van den Bosch , H. , and Pfeilschifter , J. ( 1998 ) FEBS Lett. 440 , 163-166 ) . Positive_regulation SMPD2 IL1B 15953673 1481729 In this report , we show that *induces* the transient activation of a [neutral sphingomyelinase] in porcine thyroid cells . Positive_regulation SMPD2 IL1R2 10704249 672794 Activation of [neutral sphingomyelinase] by IL-1beta *requires* the type 1 . Positive_regulation SMPD2 MMP28 17561096 1753417 The inhibitor Batimastat , MMP2-specific siRNA , and MMP2 deletion ( MMP2 ( -/- ) fibroblasts ) *blocked* [nSMase] activation and SMC proliferation , suggesting a role for MMP2 in this signaling pathway . Positive_regulation SMPD2 MMP7 17561096 1753432 The inhibitor Batimastat , MMP2-specific siRNA , and MMP2 deletion ( MMP2 ( -/- ) fibroblasts ) *blocked* [nSMase] activation and SMC proliferation , suggesting a role for MMP2 in this signaling pathway . Positive_regulation SMPD2 PLAU 19735728 2147175 This study was carried out to investigate how *activates* [NSMase-2] . Positive_regulation SMPD2 PLAU 19735728 2147176 We report that , as well as its catalytically inactive N-amino fragment ATF , *triggers* the sequential activation of MMP-2 , [NSMase-2] and ERK1/2 in ECV304 cells that are required for uPA induced ECV304 proliferation , as assessed by the inhibitory effect of Marimastat ( a MMP inhibitor ) , MMP-2-specific siRNA , MMP-2 defect , and NSMase-specific siRNA . Positive_regulation SMPD2 SELL 9716456 528306 *stimulates* the [neutral sphingomyelinase] and induces release of ceramide . Positive_regulation SMPD2 SELL 9716456 528307 Stimulation of Jurkat T-lymphocytes via *results* in an increase of [neutral sphingomyelinase] activity . Positive_regulation SMPD2 SELL 9716456 528309 The *activation* of the [neutral sphingomyelinase] by does not depend on tyrosine kinase activity and , therefore , represents an alternative and novel pathway to stimulate lymphocytes via L-selectin . Positive_regulation SMPD2 TNF 10228161 610879 An essential role of FAN in the *induced* activation of [N-SMase] was demonstrated using thymocytes from FAN knockout mice . Positive_regulation SMPD2 TNF 10359574 619105 Inhibition of the TNFR-I/FAN ( factor associated with neutral sphingomyelinase ) interaction , which is essential for dependent *activation* of the [neutral sphingomyelinase] , either by cell-permeable peptides or by deletion of the FAN binding domain , prevents activation of c-Raf-1 kinase . Positive_regulation SMPD2 TNF 10601289 574363 Stable expression of a dominant negative form of the FAN protein ( factor associated with neutral sphingomyelinase activation ) , which has been reported to mediate *induced* activation of [neutral sphingomyelinase] , significantly inhibited CD40 ligand induced sphingomyelinase stimulation and apoptosis of transformed human fibroblasts . Positive_regulation SMPD2 TNF 11001563 580802 A further role of ceramide and N-SMase in atherosclerosis was uncovered by the finding that Ox-LDL and *stimulated* [N-SMase] activity . Positive_regulation SMPD2 TNF 11311151 804931 Interestingly , stimulation of fibroblasts with *resulted* in a partial shift of its p55 receptor to caveolin enriched membrane fractions and the appearance of caveolin-sensitive [neutral sphingomyelinase] activity in the non-caveolar fractions . Positive_regulation SMPD2 TNF 12154098 997641 The compound was then evaluated for its ability to inhibit *induced* activation of [neutral SMase (N-SMase)] in MCF7 cells . Positive_regulation SMPD2 TNF 12391233 1007315 Furthermore , *activation* of [N-SMase] by was strongly enhanced when RACK1 , FAN , and a noncytotoxic TNF-R55 mutant were expressed concurrently , suggesting RACK1 as a modulator of N-SMase activation . Positive_regulation SMPD2 TNF 14689449 1194512 Both staurosporine and *induced* apoptosis and [activated NSMase] in a multiphasic manner in both OPC and HOG cells . Positive_regulation SMPD2 TNF 14732751 1202742 In cardiomyocytes obtained from control rats , 25 ng/mL *increased* reactive oxygen species generation and [N-SMase] activity ( 500 % and 34 % over basal , respectively ) and decreased the amplitude of [ Ca ( 2+ ) ] ( i ) in response to electrical stimulation ( 22 % below basal ) . Positive_regulation SMPD2 TNF 16033420 1436114 Abeta , , or the combination of both , *increased* [neutral sphingomyelinase (nSMase)] activity , but not acidic sphingomyelinase (aSMase) activity , leading to ceramide accumulation . Positive_regulation SMPD2 TNF 16269668 1502353 Inhibition of N-SMase2 inhibited Sph1P formation , whereas inhibition of SK1 did not affect [N-SMase2] *activation* by . Positive_regulation SMPD2 TNF 16691498 1560348 In summary , our studies suggest that *induced* [N-SMase] activation and production of ceramide is required to activate the apoptosis pathway in human osteosarcoma cells . Positive_regulation SMPD2 TNF 16936207 1609011 Our data also suggest that hyperinsulinemia and elevated associated with obesity may *contribute* to the observed increase in adipose [NSMase] , ASMase , and SPT mRNA in this murine model of obesity . Positive_regulation SMPD2 TNF 17085432 1675745 Additionally , *increased* [N-SMase] activity rapidly and transiently both endogenously and in cells overexpressing nSMase2 . Positive_regulation SMPD2 TNF 17283058 1718389 The mechanism of *induced* [nSMase] activation is only partly understood . Positive_regulation SMPD2 TNF 18653803 1960510 However , PMA did not increase in vitro N-SMase activity and PKC-delta did not regulate *induced* [N-SMase] activity . Positive_regulation SMPD2 TNF 20080539 2205761 Although *activation* of [N-SMase] by the proinflammatory cytokine was described almost two decades ago , the underlying signaling pathway is unresolved . Positive_regulation SMPD2 TNF 21303347 2447632 In MCF-7 cells , we found that *induces* late , but not early , increases in [N-SMase] activity , and that nSMase2 is the primary isoform activated , most likely through post-transcriptional mechanisms . Positive_regulation SMPD2 TNF 21904434 2478269 Recent studies have identified a small region at the very N-terminus of the 55 kDa tumour necrosis factor receptor ( TNF-R55 ) , designated the neutral sphingomyelinase activating domain ( NSD ) that is responsible for the *induced* activation of [N-SMase] . Positive_regulation SMPD2 TNF 9478955 487037 TNF-alpha is capable of inducing SREBP-1 maturation in a time- and dose dependent manner that is consistent with the kinetics of mediated *activation* of [neutral sphingomyelinase (N-SMase)] . Positive_regulation SMPD3 EPHB2 17085432 1675773 Furthermore , the translocation of [nSMase2] was *regulated* by p38-alpha MAPK , but not or JNK , and the increase in endogenous N-SMase activity was abrogated by p38 MAPK inhibition . Positive_regulation SMPD3 TNF 12566438 1079233 Moreover , *induced* approximately 50 % activation of [nSMase2] in MCF7 cells overexpressing the enzyme , demonstrating that nSMase2 is a tumor necrosis factor-responsive enzyme . Positive_regulation SMPD3 TNF 17085432 1675800 These data reveal p38 MAPK as an upstream regulator of nSMase2 and indicate a role for [nSMase2] in pro-inflammatory responses *induced* by as a regulator of adhesion proteins . Positive_regulation SMPD3 TNF 18653803 1960508 Here , we report a role for protein kinase C ( PKC ) in mediating *induced* translocation of [nSMase2] from the Golgi to the plasma membrane ( PM ) . Positive_regulation SMPD3 TNF 18653803 1960509 Pharmacological inhibition of PKCs prevented *stimulated* [nSMase2] translocation to the PM in A549 cells . Positive_regulation SMPD3 TNF 20080539 2205764 In yeast , the N terminus of EED binds to the catalytic domain of nSMase2 as well as to RACK1 , a protein that modulates the *activation* of [nSMase2] by in concert with the TNF receptor 1 (TNF-R1) associated protein FAN . Positive_regulation SMPD3 TNF 20080539 2205768 In mammalian cells , *causes* endogenous EED to translocate from the nucleus and to colocalize and physically interact with both endogenous [nSMase2] and RACK1 . Positive_regulation SMPD3 TNF 20080539 2205771 After knockdown of EED by RNA interference , the *dependent* activation of [nSMase2] is completely abrogated , identifying EED as a protein that both physically and functionally couples TNF-R1 to nSMase2 , and which therefore represents the `` missing link '' that completes one of the last unresolved signaling pathways of TNF-R1 . Positive_regulation SMPD3 TNF 24007266 2866581 Although enhanced binding of nSMase2 with RACK1 and EED were also observed after cerebral ischemia , [nSMase2] activity was not *blocked* by the receptor inhibitor through RACK1/EED signaling . Positive_regulation SMPD4 TNF 16517606 1555063 *stimulates* rapid activation of [nSMase3] in MCF7 cells with peak activity at 1 .5 min , which was impaired by expression of dominant negative FAN . Positive_regulation SMURF1 TNF 16373342 1519704 We treated C2C12 and 2T3 osteoblast precursor cell lines and primary osteoblasts with TNF and found that , but not interleukin-1 , significantly *increased* [Smurf1] and Smurf2 expression . Positive_regulation SMURF1 TNF 18567580 1946390 We conclude that in chronic inflammatory disorders where TNF is increased , *induces* the expression of ubiquitin ligase [Smurf1] and promotes ubiquitination and proteasomal degradation of Smad1 and Runx2 , leading to systemic bone loss . Positive_regulation SMURF1 TNF 22396737 2566832 also *induces* the expression of E3 ubiquitin ligase protein [Smurf1] and Smurf2 and promotes degradation of Runx2 , another key transcription factor regulating osteoblast differentiation and bone formation . Positive_regulation SMURF2 TNF 16373342 1519732 We treated C2C12 and 2T3 osteoblast precursor cell lines and primary osteoblasts with TNF and found that , but not interleukin-1 , significantly *increased* Smurf1 and [Smurf2] expression . Positive_regulation SMURF2 TNF 22396737 2566833 also *induces* the expression of E3 ubiquitin ligase protein Smurf1 and [Smurf2] and promotes degradation of Runx2 , another key transcription factor regulating osteoblast differentiation and bone formation . Positive_regulation SNAI1 ID1 22278018 2580174 also *induced* [Snail1] expression and triggered tubular epithelial dedifferentiation . Positive_regulation SNAI1 VSNL1 22479362 2578861 These findings indicate that is *involved* in EMT of SCC by regulating the transcription factor [Snail1] in a cAMP dependent manner . Positive_regulation SNAI2 MAP2K6 17525203 1746121 TGFbeta1 induced [Slug] expression was significantly *inhibited* by the and JNK/SAPK-specific inhibitors , but not by transfection with dominant negative forms of Smads or small GTPase proteins , indicating that MAPK pathways are involved in the regulation of Slug expression by TGFbeta1 . Positive_regulation SNAP23 SYT8 12526776 1048168 Thus , triggering of the fast component of release by Sr ( 2+ ) as a Ca ( 2+ ) agonist involves the formation of complexes , but does not *require* stimulated [SNARE] binding . Positive_regulation SNAP25 CAPN8 18721885 1974991 Using selectively enriched cultures of fast spiking GABAergic interneurons , we show that activity partially *contributes* to the post-translational down regulation of [SNAP-25] , a calpain substrate , in differentiated GABA cells . Positive_regulation SNAP25 FAS 17343612 1707858 and finally , the NO donor [SNAP] *induces* considerable up-regulation in tumours in vitro . Positive_regulation SNAP25 SYT8 10617122 656707 Stimulation of Ca2+/calmodulin dependent protein kinase II , which endogenously phosphorylates synaptotagmin in synaptic vesicles , *increased* the interaction of syntaxin and [SNAP-25] with ( particularly when measured in the presence of calcium ) , as well as increasing the binding of the kinase itself . Positive_regulation SNCA IL1B 11435921 832705 Expression of [alpha-synuclein] in a human glioma cell line and its *up-regulation* by . Positive_regulation SNCA IL1B 12406186 1009986 Recently , we reported that [alpha-synuclein] is also expressed in cultured human astrocytes and that its levels are *increased* by stimulation with , suggesting that it may be involved in inflammatory processes . Positive_regulation SNCA IL1B 12406186 1009987 Alpha-synuclein mRNA and protein were detected in cultured human macrophages and levels of [alpha-synuclein] protein were *increased* by stimulation with lipopolysaccharide and in a time- and concentration dependent manner . Positive_regulation SNCA PTGER2 17204153 1681258 We investigated the *role* of prostaglandin in [alpha-synuclein] aggregation induced microglial activation using ex vivo , in vivo and in vitro experimental systems . Positive_regulation SNCA SNCAIP 17467279 1743427 Since both parkin and have been *involved* in [Lewy body (LB)] formation , we decided to explore whether their isoforms are differentially expressed in LB diseases . Positive_regulation SNCA TF 14742448 1226183 We investigated the *role* of and iron in modulating the expression of [alpha-synuclein] ( alpha-syn ) in MPP ( + ) -induced oxidative stress and apoptosis . Positive_regulation SNCAIP ALB 11071638 748127 Platelet [Sph-1-P] release , possibly mediated by protein kinase C , was greatly enhanced in the *presence* of , which formed a complex with Sph-1-P . Positive_regulation SNCAIP CA2 7795224 313579 [Sph-1-P] *induced* intracellular mobilization and the dose-response for Ca2+ release correlated closely with the concentration required for induction of shape change . Positive_regulation SNCAIP CSNK2A1 14645218 1201640 phosphorylation *regulates* [alpha-synuclein/synphilin-1] interaction and inclusion body formation . Positive_regulation SNCAIP CSNK2A2 14645218 1201641 phosphorylation *regulates* [alpha-synuclein/synphilin-1] interaction and inclusion body formation . Positive_regulation SNCAIP CSNK2B 14645218 1201642 phosphorylation *regulates* [alpha-synuclein/synphilin-1] interaction and inclusion body formation . Positive_regulation SNCAIP MYL1 10788802 688997 [Sph-1-P] *induced* FAK tyrosine phosphorylation , phosphorylation , and the formation of stress fibers in HUVECs . Positive_regulation SNCAIP MYL10 10788802 688996 [Sph-1-P] *induced* FAK tyrosine phosphorylation , phosphorylation , and the formation of stress fibers in HUVECs . Positive_regulation SNCAIP MYL2 10788802 688998 [Sph-1-P] *induced* FAK tyrosine phosphorylation , phosphorylation , and the formation of stress fibers in HUVECs . Positive_regulation SNCAIP MYL3 10788802 688999 [Sph-1-P] *induced* FAK tyrosine phosphorylation , phosphorylation , and the formation of stress fibers in HUVECs . Positive_regulation SNCAIP MYL4 10788802 689000 [Sph-1-P] *induced* FAK tyrosine phosphorylation , phosphorylation , and the formation of stress fibers in HUVECs . Positive_regulation SNCAIP MYL5 10788802 689001 [Sph-1-P] *induced* FAK tyrosine phosphorylation , phosphorylation , and the formation of stress fibers in HUVECs . Positive_regulation SNCAIP MYL6 10788802 689002 [Sph-1-P] *induced* FAK tyrosine phosphorylation , phosphorylation , and the formation of stress fibers in HUVECs . Positive_regulation SNCAIP MYL7 10788802 688995 [Sph-1-P] *induced* FAK tyrosine phosphorylation , phosphorylation , and the formation of stress fibers in HUVECs . Positive_regulation SNCAIP MYL9 10788802 688994 [Sph-1-P] *induced* FAK tyrosine phosphorylation , phosphorylation , and the formation of stress fibers in HUVECs . Positive_regulation SNCAIP NUB1 16877356 1593704 Further , biochemical assays revealed that overexpression *leads* to the proteasomal degradation of [synphilin-1] . Positive_regulation SNCAIP SLC2A4RG 23284848 2711628 However , the kalirin-7 mediated [synphilin-1] aggresome response was not *dependent* on the activity of kalirin-7 since various dominant negative small GTPases could not inhibit the formation of aggresomes . Positive_regulation SNCAIP SMPD2 16269668 1502354 Inhibition of *inhibited* [Sph1P] formation , whereas inhibition of SK1 did not affect N-SMase2 activation by TNF-alpha . Positive_regulation SND1 TNF 23160072 2745350 Proinflammatory cytokine *caused* an increase of [SND1] promoter activity that is mediated , at least in part , via NF-?B as mutation in the NF-?B sites impaired the promoter stimulation . Positive_regulation SNN TNF 16453279 1540705 can *induce* [Snn] mRNA expression in endothelial cells in a PKC-epsilon dependent manner . Positive_regulation SNN TNF 16572589 1543279 We have recently demonstrated in human umbilical vein endothelial cells ( HUVECs ) that [Snn] gene expression is significantly *induced* by in a protein kinase C-epsilon ( PKC-epsilon ) -dependent manner . Positive_regulation SNORA73A TNF 11571294 882329 *induces* [E1B] 19K-Bax interaction and inhibits Bax oligomerization . Positive_regulation SNORA73A TNF 9060638 417773 We now report that induces translocation of cPLA2 from the cytosol to membranes in Ad-infected human A549 cells and that E3-10.4K/14.5K but not E3-14.7K or [E1B-19K] is *required* to inhibit TNF induced translocation of cPLA2 . Positive_regulation SNRPA SMN2 10901626 712799 Immunolocalization studies using SMN monoclonal antibody showed that is decreased in cultures grown in low K+ or chemically defined medium with respect to cultures grown in high K+ medium and that an increase of [SMN] can be *induced* by treatment of low K+ cultures with glutamate or N-methyl-D-aspartate . Positive_regulation SNRPB SMN2 10901626 712806 Immunolocalization studies using SMN monoclonal antibody showed that is decreased in cultures grown in low K+ or chemically defined medium with respect to cultures grown in high K+ medium and that an increase of [SMN] can be *induced* by treatment of low K+ cultures with glutamate or N-methyl-D-aspartate . Positive_regulation SNRPD2 TNF 18384879 1913076 Release of [sMD-2] by endothelial cells was strongly *enhanced* by LPS and stimulation . Positive_regulation SOAT1 CTGF 15924723 1414108 ( 5 ) Ten nmol/L Lipoxin A ( 4 ) antagonized *induced* increase of [STAT] ( 3 ) DNA binding activity , and its antagonistic effect on HLF/LRLP was more powerful than that on HLF ( P < 0.05 ) . Positive_regulation SOAT1 EPHB2 12955078 1137677 Further biochemical analyses revealed that IL-3 *induced* [Jak/Stat] , , and PI3 kinase pathways in SHP-2 ( -/- ) cells were impaired and reintroduction of WT SHP-2 into mutant cells partially restored IL-3 signaling . Positive_regulation SOAT1 EPHB2 15948243 1421103 PDGF-BB induced [STAT-specific] binding activity , and *activation* of Src , JAK2 , STAT1 , STAT3 , and . Positive_regulation SOAT1 FHL1 15963787 1423179 Overexpression of SLIM leads to impaired STAT1 and STAT4 activity due to reduced STAT protein levels , while *results* in increased [STAT] expression and thus enhanced IFNgamma production by Th1 cells . Positive_regulation SOAT1 IL1B 19834007 2164908 Promoter analysis showed that stretch mediated *activates* [JAK/STAT] to transcriptionally regulate the IGF-1 gene . Positive_regulation SOAT1 JAG1 24115357 2896440 We show that the transplantation of hESC derived OPC and MP promotes astrogliosis , through activation of *dependent* Notch and [Jak/STAT] signaling that support axonal survival . Positive_regulation SOAT1 TNF 22121136 2548498 Unexpectedly , although did not *induce* immediate phosphorylation of either [STAT] , CP-690,550 inhibited TNF induced expression of several chemokines ( IP-10 , RANTES and MCP1 ) at the messenger RNA and protein levels . Positive_regulation SOAT1 TNF 9510175 491840 *Induction* of [Jak/STAT] signaling by activation of the type 1 receptor . Positive_regulation SOAT2 TNF 19189937 2071622 In this article , we show that in cultured , differentiating human monocytes , *enhances* the expression of the ACAT1 but not [ACAT2] gene , increases the cholesteryl ester accumulation , and promotes the lipid-laden cell formation . Positive_regulation SOCS1 IFI27 11818334 908167 [Jab1] was initially identified as a co-activator of c-Jun , and it also *induces* degradation of cell cycle inhibitor and tumor suppressor p53 . Positive_regulation SOCS1 IL1B 20067833 2212258 These results indicated that glucose induced endogenous expression *increased* betaTC-6 cells apoptosis by inhibiting , at least in part , IRS-2/Akt mediated signalling through [SOCS-1] upregulation . Positive_regulation SOCS1 ITGB2 14528303 1158389 Here , intracellular phosphoprotein staining with 13-dimensional flow cytometry showed that activation *induced* phosphorylation of the beta ( 2 ) integrin chain and release of [Jun activating binding protein 1 (JAB-1)] , and mediated signaling of kinase Erk1/2 through cytohesin-1 . Positive_regulation SOCS1 TLR7 16896155 1654080 The results indicate that stimulation during the period of DC generation interferes with and deviates DC differentiation and that these effects are *mediated* particularly by [SOCS-1] . Positive_regulation SOCS1 TNF 12077274 957060 We show in this work that SOCS1 , SOCS2 , SOCS3 , and cytokine-inducible SH2 containing protein mRNA were up-regulated by IFN-gamma in normal human keratinocytes , whereas only SOCS1 or [SOCS1] and cytokine-inducible SH2 containing protein were *induced* by or IL-4 , respectively . Positive_regulation SOCS1 TNF 15072573 1232601 Furthermore , and GH *caused* sustained upregulation of [SOCS-1] for up to 24 h , whereas stimulation by IL-6 was only transient , with SOCS-1 mRNA returning to basal levels 2 h after effector addition . Positive_regulation SOCS1 TNF 19561639 2129018 In Jurkat T cells and mouse splenocytes , we have found that [SOCS1] is induced in *response* to or H ( 2 ) O ( 2 ) , concomitant with the activation of Jaks which act as important mediators of reactive oxygen species ( ROS ) -induced apoptosis upstream of p38 mitogen activated protein kinase . Positive_regulation SOCS1 TNF 20127972 2272277 stimulation *augmented* [SOCS1] , whereas SOCS3 expression in tenocytes was also induced by IL-6 . Positive_regulation SOCS1 TNF 23375208 2747889 [SOCS1] was *induced* by IL-4 , IL-13 , IFN-? , and , while SOCS3 expression was upregulated by IL-6 , IL-13 , IFN-? , and TNF-a . Positive_regulation SOCS1 TNF 24659790 2949102 In this study , we found that both [SOCS1] and SOCS3 were transiently *induced* by and negatively regulate its NF-?B mediated signal transduction . Positive_regulation SOCS2 IL1B 10969179 728335 In tonsillar cells , CIS expression was increased and [SOCS-2] was *induced* by , IL-6 , PRL and GH . Positive_regulation SOCS2 IL1B 10969179 728346 In Raji B-lymphoma cells , the expression of [SOCS-2] and SOCS-7 was *enhanced* by . Positive_regulation SOCS3 EPHB2 19423709 2096143 Activation of protein kinase Calpha by EPAC1 is required for the and CCAAT/enhancer binding protein beta dependent *induction* of the [SOCS-3] gene by cyclic AMP in COS1 cells . Positive_regulation SOCS3 EPHB2 22311708 2580500 In addition AP-1 , pSTAT , and SP1/SP3 binding sites were required for *dependent* , PMA stimulated [SOCS-3] gene activation . Positive_regulation SOCS3 IL1B 10660535 664475 We conclude that the *induction* of [SOCS3] by contributes to the development of GH resistance in liver , and represents a mechanism by which cytokines such as IL-1beta cross-talk with cytokines using the JAK-STAT pathway . Positive_regulation SOCS3 IL1B 10969179 728344 [SOCS-3] expression was *enhanced* by . Positive_regulation SOCS3 IL1B 11014223 736326 Although and TNFalpha alone *induced* only weakly the expression of [SOCS-3] and CIS , these cytokines strongly potentiated the induction of these two SOCS by GH . Positive_regulation SOCS3 IL1B 11014223 736332 Considering the ability of these SOCS to inhibit the JAK-STAT pathway induced by GH , these results suggest that the overexpression of [SOCS-3] and CIS mRNAs *induced* by and TNFalpha or by endotoxin in vivo may play a role in the GH resistance induced by sepsis . Positive_regulation SOCS3 IL1B 15308667 1303466 In hepatocytes alone does not *induce* [SOCS3] expression , but it counteracts SOCS3-promoter activation in long term studies . Positive_regulation SOCS3 IL1B 15561930 1341214 We show that increases SOCS-3 expression and *induces* [SOCS-3/IR] complex formation in RINm5F cells . Positive_regulation SOCS3 IL1B 20067961 2241606 Although both glucose and cream induce NF-kappaB binding and an increase in the expression of [SOCS3] , TNF-alpha , and in MNCs , only cream *caused* an increase in LPS concentration and TLR-4 expression . Positive_regulation SOCS3 MAP2K6 21367976 2431762 JNK and inhibitors *suppressed* hBD-2 induced expression of [SOCS3] . Positive_regulation SOCS3 MAP2K6 25035930 2953273 Wogonin induced [SOCS3] expression was *blocked* by inhibitors of PI3K , Akt , Raf , p38 , JNK , , and STAT3 , respectively . Positive_regulation SOCS3 TLR7 15491991 1347427 *Induction* of [SOCS-3] and cytokine-inducible Src homology 2-containing protein ( CIS ) by stimulation was strictly dependent on MyD88 but showed differing needs in case of SOCS-1 . Positive_regulation SOCS3 TNF 11014223 736325 Although IL-1/beta and alone *induced* only weakly the expression of [SOCS-3] and CIS , these cytokines strongly potentiated the induction of these two SOCS by GH . Positive_regulation SOCS3 TNF 11014223 736331 Considering the ability of these SOCS to inhibit the JAK-STAT pathway induced by GH , these results suggest that the overexpression of [SOCS-3] and CIS mRNAs *induced* by IL-1beta and or by endotoxin in vivo may play a role in the GH resistance induced by sepsis . Positive_regulation SOCS3 TNF 11604392 888230 Strikingly , *induced* a sustained [SOCS-3] expression , essentially in the WAT . Positive_regulation SOCS3 TNF 12817006 1103559 Recently , it has been demonstrated that and LPS *induce* the expression of [suppressor of cytokine signaling 3] ( SOCS3 ) and inhibit IL-6 induced STAT3 activation in macrophages . Positive_regulation SOCS3 TNF 15893771 1419773 LPS and *activated* STAT3 and [SOCS3] in pancreatic acinar cells . Positive_regulation SOCS3 TNF 17312125 1699662 In this study , we investigate [SOCS3] expression *initiated* by the proinflammatory cytokine . Positive_regulation SOCS3 TNF 17312125 1699663 In contrast to IL-6 , *increases* [SOCS3] expression by stabilizing SOCS3 mRNA . Positive_regulation SOCS3 TNF 17312125 1699665 In summary , these data indicate that *regulates* [SOCS3] expression on the level of mRNA stability via activation of the MKK6/p38 ( MAPK ) cascade and that the activation of MK2 , a downstream target of p38 ( MAPK ) , is important for the regulation of SOCS3 expression . Positive_regulation SOCS3 TNF 24659790 2949103 In this study , we found that both SOCS1 and [SOCS3] were transiently *induced* by and negatively regulate its NF-?B mediated signal transduction . Positive_regulation SOCS6 EPHB2 17210122 1688986 We found that both and Pkcdelta activation were *required* for the increased [SOCS6] stability by PMA . Positive_regulation SOCS7 IL1B 10969179 728347 In Raji B-lymphoma cells , the expression of SOCS-2 and [SOCS-7] was *enhanced* by . Positive_regulation SOD1 ABCA12 10682609 478625 In the tests of inhibition and prevention of tumor , could significantly inhibit the grouth of the two kinds of tumor , and *increase* the activity of [superoxide dismutage (SOD)] and decrease the contents of Malonyldialdehyde ( MDA ) . Positive_regulation SOD1 ARSA 14504662 1144683 NO-ASA , but not , *caused* an upregulation of [SOD] and GPx mRNA in gastric mucosa with or without sensory denervation . Positive_regulation SOD1 ARSA 25069161 2953781 Exogenous and GSH *enhanced* [SOD] , APX , and GR activities , increased endogenous AsA and GSH contents , and reduced those of H2O2 and MDA in the chloroplasts of both cultivars under salt stress ( 200 mM NaCl ) , but the effects were significantly more pronounced in cv. Pokkali . Positive_regulation SOD1 EPHB2 16966488 1627823 Phosphorylation of led to an activation of NFkappaB , as indicated by increased p50 subunit expression in nuclear extracts , and *increased* mRNA levels of the antioxidant enzyme [manganese-superoxide dismutase] ( MnSOD ) . Positive_regulation SOD1 FAS 15799963 1410366 High molecular mass aggregates of [SOD1] *induced* by have a granular morphology and show significant cytotoxicity . Positive_regulation SOD1 FOXO1 15492127 1321446 IFN-gamma-driven expression of tryptophan catabolism by CTLA-4-immunoglobulin is made possible through the concomitant activation of the transcription factor FOXO3a , *induction* of the [superoxide dismutase] gene , and prevention of peroxynitrite formation . Positive_regulation SOD1 FOXO1 17408630 1728354 directly *induces* the expression of p27 ( kip1 ) and manganese [superoxide dismutase] ( MnSOD ) . Positive_regulation SOD1 FOXO1 19426753 2090217 overexpression could not *prevent* aging induced reduction in catalase , [CuZu-SOD] , and Mn-SOD mRNA in skeletal muscle . Positive_regulation SOD1 IL1B 10076538 560585 also *increased* cytosolic [Cu/Zn-superoxide dismutase (SOD)] and mitochondrial Mn-SOD in RINm5F cells . Positive_regulation SOD1 IL1B 10359573 619100 The production of reactive oxygen species and endogenous TNF-alpha and induced by exercise *leads* to the activation of [Mn-SOD] , which plays major roles in the acquisition of biphasic cardioprotection against ischemia/reperfusion injury in rats . Positive_regulation SOD1 IL1B 10492402 646576 An intronic NF-kappaB element is essential for *induction* of the human manganese [superoxide dismutase] gene by tumor necrosis factor-alpha and . Positive_regulation SOD1 IL1B 10903806 713228 When added together , p38i and MEKi decreased IL-1 beta induced nitrite production over 24 hours by 60 % , but did not affect *induced* manganese [superoxide dismutase] ( MnSOD ) mRNA expression . Positive_regulation SOD1 IL1B 11015290 737496 We conclude that the induction and activation of [Mn-SOD] , *mediated* by TNF-alpha and after IP , plays an important role in the acquisition of late-phase cardioprotection against ischaemia/reperfusion injury in rats . Positive_regulation SOD1 IL1B 11860476 893735 The evidence presented supports the view that this is secondary to the stress induced increase in IL-1beta concentration , as *increased* activity of [superoxide dismutase] and increased reactive oxygen species accumulation in hippocampus in vitro . Positive_regulation SOD1 IL1B 1533363 186499 *increases* the activity of [superoxide dismutase] in rat pancreatic islets . Positive_regulation SOD1 IL1B 18291685 1924864 In parallel , markedly *enhanced* Mn [SOD] and GPX gene expressions , but decreased Cu/Zn SOD , EC SOD and CAT gene expressions . Positive_regulation SOD1 IL1B 18559338 1959160 *Induction* of [Mn-SOD] gene expression by the proinflammatory cytokine is mediated through a complex intronic enhancer element . Positive_regulation SOD1 IL1B 7515058 257105 While and interleukin-6 *induced* [manganese-superoxide dismutase] gene expression , they slightly suppressed catalase gene expression in rat hepatocytes . Positive_regulation SOD1 IL1B 7539260 306995 We presently investigated the effects of pyrrolidine dithiocarbamate ( PDTC ) , a potent inhibitor of nuclear factor kappa B (NF-kappa B) , on the *induction* of nitric oxide synthase ( iNOS ) and manganese [superoxide dismutase] ( MnSOD ) mRNAs by in insulin producing RIN cells . Positive_regulation SOD1 IL1B 8719114 343862 *induces* the expression of hsp70 , heme oxygenase and [Mn-SOD] in FACS purified rat islet beta-cells , but not in alpha-cells . Positive_regulation SOD1 IL1B 9038369 415536 and TNF-alpha both *stimulated* specifically [Mn-SOD] gene expression in a time dependent manner . Positive_regulation SOD1 IL1B 9038369 415542 TNF-alpha rapidly *induced* [Mn-SOD] gene expression while was a strong but slow inducer of this gene . Positive_regulation SOD1 IL1B 9038369 415554 These results suggest that and TNF-alpha *regulate* [Mn-SOD] gene transcription by different pathways . Positive_regulation SOD1 IL1B 9372929 464426 Tumor necrosis factor alpha and *regulate* the murine manganese [superoxide dismutase] gene through a complex intronic enhancer involving C/EBP-beta and NF-kappaB . Positive_regulation SOD1 IL1B 9473516 486398 However , under basal conditions *had* no significant effect on [ALS] mRNA levels , and only a slight suppression of secretion . Positive_regulation SOD1 IL1B 9473516 486400 Our study suggests that *regulates* [ALS] gene expression and secretion in a way that is dependent , in part , on interaction with the GH signalling pathway . Positive_regulation SOD1 LBP 21077258 2419193 also played a significant role in the recovery of serum testosterone levels , *increased* [superoxide dismutase] activity , decreased malondialdehyde levels , promoted oxidative balance and rescued testicular DNA damage . Positive_regulation SOD1 LBP 24174357 2860262 At the same time , significantly decreased MDA content , and *increased* [SOD] , GSH-Px , CAT , LDH activities in ischemic reperfusion brain . Positive_regulation SOD1 OSR1 24078262 2867246 Moreover , markedly decreased MDA content , and *increased* [SOD] , GSH-Px activities . Positive_regulation SOD1 PGC 21054343 2376353 Reducing expression also *led* to reduced mRNA expression levels of uncoupling protein 1 , 2 ( UCP1 and UCP2 ) and [superoxide dismutase] 2 . Positive_regulation SOD1 RCAN1 14718387 1197590 We found that ( Adapt78 ) expression *stimulates* [SOD1] ( intracellular Cu , Zn superoxide dismutase ) gene expression and increased sod 1 enzyme activity . Positive_regulation SOD1 TNF 10359573 619099 The production of reactive oxygen species and endogenous and IL-1beta induced by exercise *leads* to the activation of [Mn-SOD] , which plays major roles in the acquisition of biphasic cardioprotection against ischemia/reperfusion injury in rats . Positive_regulation SOD1 TNF 10492402 646575 An intronic NF-kappaB element is essential for *induction* of the human manganese [superoxide dismutase] gene by and interleukin-1beta . Positive_regulation SOD1 TNF 10760955 683683 A NF-kappaB p65 subunit is indispensable for activating manganese [superoxide: dismutase] gene transcription *mediated* by . Positive_regulation SOD1 TNF 10760955 683686 Expression of the manganese [superoxide dismutase] ( Mn-SOD ) is *induced* by , interleukin-1 (IL-1) , and lipopolysaccharide (LPS) . Positive_regulation SOD1 TNF 10760955 683698 This report describes the minimal promoter region of the Mn-SOD gene and investigates the cis acting elements and trans acting factors responsible for *induced* [Mn-SOD] gene expression . Positive_regulation SOD1 TNF 10760955 683723 These results show that a NF-kappaB p65 subunit is mainly involved in the molecular mechanisms controlling *mediated* [Mn-SOD] gene transcription . Positive_regulation SOD1 TNF 10924720 718397 The [Mn-SOD] activity was strongly *up-regulated* by and IL-1alpha and moderately by IFN-gamma . Positive_regulation SOD1 TNF 11015290 737495 We conclude that the induction and activation of [Mn-SOD] , *mediated* by and IL-1beta after IP , plays an important role in the acquisition of late-phase cardioprotection against ischaemia/reperfusion injury in rats . Positive_regulation SOD1 TNF 11675473 873375 *increased* [manganese-SOD] ( Mn-SOD ) mRNA level and Mn-SOD activity in a dose dependent manner in ESC . Positive_regulation SOD1 TNF 11675473 873378 *had* no effect on [copper-zinc-SOD] ( Cu , Zn-SOD ) expression in either type of cell . Positive_regulation SOD1 TNF 11675473 873384 Incubation of ESC with actinomycin D , an RNA synthesis inhibitor , blocked *induced* [Mn-SOD] mRNA expression , but cycloheximide , a protein synthesis inhibitor , had no effect . Positive_regulation SOD1 TNF 11675473 873387 H7 , an inhibitor of protein kinase C ( PKC ) , also inhibited *stimulated* [Mn-SOD] mRNA expression in both types of cells . Positive_regulation SOD1 TNF 11675473 873390 These findings suggest that *induced* [Mn-SOD] expression is regulated at the transcription level and mediated by PKC dependent phosphorylation and that de-novo protein synthesis is not required for the TNFalpha effect . Positive_regulation SOD1 TNF 11675473 873393 In summary , *induces* [Mn-SOD] expression in human ESC . Positive_regulation SOD1 TNF 12161520 971939 Nuclear factor-kappa B is required for *induced* manganese [superoxide dismutase] expression in human endometrial stromal cells . Positive_regulation SOD1 TNF 12161520 971942 We recently found that manganese [superoxide dismutase] ( Mn-SOD ) is *up-regulated* by at the transcription level in human endometrial stromal cells ( ESC ) and that TNF alpha induced Mn-SOD expression is mediated by protein kinase C ( PKC ) -dependent phosphorylation . Positive_regulation SOD1 TNF 12161520 971945 This study was undertaken to investigate whether nuclear factor-kappa B (NF-kappa B) , a transcription factor , is involved in [Mn-SOD] *induction* by or PKC in human ESC . Positive_regulation SOD1 TNF 12161520 971962 and TPA significantly *increased* [Mn-SOD] activities and Mn-SOD mRNA levels , and those effects were completely inhibited by MG132 and SN50 . Positive_regulation SOD1 TNF 12161520 971965 In conclusion , the present study showed the involvement of NF-kappa B in [Mn-SOD] *induction* by or PKC in human ESC . Positive_regulation SOD1 TNF 12684509 1099797 Role of the intronic enhancer in *mediated* induction of manganous [superoxide dismutase] . Positive_regulation SOD1 TNF 12684509 1099804 These assays demonstrate that Sp1 and nuclear factor (NF)-kappaB p65 are required for [Mn-SOD] *induction* by . Positive_regulation SOD1 TNF 1311566 178920 *Induction* of [Mn-superoxide dismutase] by , interleukin-1 and interleukin-6 in human hepatoma cells . Positive_regulation SOD1 TNF 1311566 179012 Both and IL-1 *enhanced* the [Mn-SOD] production to the level of 30- to 40-fold . Positive_regulation SOD1 TNF 1313774 182489 *induces* synthesis of manganese [superoxide dismutase] ( MnSOD ) . Positive_regulation SOD1 TNF 1320006 190071 activates nuclear factor kappa B and *induces* manganous [superoxide dismutase] and phosphodiesterase mRNA in human papillary thyroid carcinoma cells . Positive_regulation SOD1 TNF 1427594 202449 at a low dose ( 10 U/ml ) *stimulated* production of prostaglandin E2 , [Mn-superoxide dismutase] , interleukin (IL)-6 and IL-8 by glioblastoma cells . Positive_regulation SOD1 TNF 1445297 205184 Cell killing and *induction* of manganous [superoxide dismutase] by is mediated by lipoxygenase metabolites of arachidonic acid . Positive_regulation SOD1 TNF 1445297 205187 Our data reveal that *induction* of manganous [superoxide dismutase] ( MnSOD ) is also dependent upon lipoxygenase activity . Positive_regulation SOD1 TNF 1551878 184067 , IL-1 alpha , and IFN-gamma *stimulated* the [Mn-SOD] activity , as previously known , and these responses were reduced by TGF-beta . Positive_regulation SOD1 TNF 1568640 186992 These facts suggest that secretion from the infarcted area *resulted* in the production of [Mn-SOD] and that the induced Mn-SOD was released from myocytes into serum through damaged membranes , resulting in the late elevation . Positive_regulation SOD1 TNF 16644673 1553111 Using reduced MitoTracker Red probe , we confirmed that *increased* mitochondrial ROS production , which was suppressed by overexpression of either uncoupling protein-1 (UCP)-1 or manganese [superoxide dismutase] ( MnSOD ) . Positive_regulation SOD1 TNF 1668725 177705 *induces* manganese containing [superoxide dismutase] ( MnSOD ) which also uses O2- to produce cytotoxic concentrations of hydrogen peroxide . Positive_regulation SOD1 TNF 1850207 155523 *increases* [Mn-SOD] expression : protection against oxidant injury . Positive_regulation SOD1 TNF 1850207 155529 significantly *increased* [Mn-SOD] activity and mRNA in a dose-and time dependent manner . Positive_regulation SOD1 TNF 1850207 155532 Our results suggest that the *induction* of [Mn-SOD] by in pulmonary adenocarcinoma cells is pretranslationally mediated and that increasing Mn-SOD activity with TNF-alpha confers protection against O2 radicals . Positive_regulation SOD1 TNF 18761070 1975435 Pretreatment with CGX significantly restored the reduction of catalase activity and glutathione ( GSH ) content , but not [superoxide dismutase (SOD)] activity , and it *inhibited* the CCl ( 4 ) -induced high expression of iNOS and in hepatic tissue . Positive_regulation SOD1 TNF 20112906 2206327 [SOD] and GPx expressions decreased ( p < 0.001 ) but that of *increased* significantly ( P < 0.001 ) in FT rats with respect to FC and NFT animals . Positive_regulation SOD1 TNF 20884819 2357066 Positive immunolabelings for interleukin-6 , *inducible* nitric oxide synthase , and dimeric copper- and zinc containing [superoxide dismutase] were observed mainly in the inflammatory cells in the lesions ; Positive_regulation SOD1 TNF 21040696 2376290 After edaravone treatment , levels of MDA , IL-6 , and hydroproline decreased , but [SOD] and GSH-PX activity in lung tissue and BALF *increased* . Positive_regulation SOD1 TNF 21166155 1506559 significantly decreased the release of LDH ( P < 0.05 ) and *increased* the activity of [Mn-SOD] in the myocardium ( P < 0.05 ) . Positive_regulation SOD1 TNF 2222450 144317 *Stimulation* of [Mn-superoxide dismutase] expression by : quantitative determination of Mn-SOD protein levels in TNF-resistant and sensitive cells by ELISA . Positive_regulation SOD1 TNF 2260678 146436 Molecular basis for *induced* increase in pulmonary [superoxide dismutase] activities . Positive_regulation SOD1 TNF 23895132 2825676 However , comparing to the model rabbits , levels of , IL-1ß and MDA decreased significantly and serum [SOD] activity *increased* , gene and protein expressions of E-sel , ICAM-1 , VCAM-1 and MCP-1 in aortas decreased significantly with the treatment of kaempferol . Positive_regulation SOD1 TNF 2406241 128156 We have demonstrated a dramatic induction of manganese [superoxide dismutase] ( Mn-SOD ) mRNA levels in *response* to lipopolysaccharide (LPS) , interleukin-1 , and in pulmonary epithelial cells . Positive_regulation SOD1 TNF 2547375 115558 *Induction* of manganese [superoxide dismutase] by in human breast cancer MCF-7 cell line and its TNF-resistant variant . Positive_regulation SOD1 TNF 2547375 115561 *induced* more mitochondrial manganese [SOD] ( SODm ) in MCF-7 than in Tnf-1000 whereas there appeared to be no significant induction of cytosolic copper/zinc SOD ( SODc ) by TNF in both MCF-7 and Tnf-1000 cell lines . Positive_regulation SOD1 TNF 3263703 101264 *Induction* of manganous [superoxide dismutase] by : possible protective mechanism . Positive_regulation SOD1 TNF 7760346 307917 Leukemia inhibitory factor and *induce* manganese [superoxide dismutase] and protect rabbit hearts from reperfusion injury . Positive_regulation SOD1 TNF 8260539 238833 Cytotoxicity and manganese [superoxide dismutase] *induction* by and ionizing radiation in MCF-7 human breast carcinoma cells . Positive_regulation SOD1 TNF 8292376 248028 Manganous [superoxide dismutase] ( MnSOD ) gene expression is *stimulated* by endotoxin , , and interleukin-1 , agents thought to cause cellular damage through intracellular generation of reactive oxygen species . Positive_regulation SOD1 TNF 8317554 222969 Both manganese [SOD] and copper , zinc SOD activities were significantly *induced* by paraquat , interleukin-1 , , adriamycin , and bleomycin in lymphocytes and neutrophils from asymptomatic non aged adults , whereas neither activity was induced in aged individuals . Positive_regulation SOD1 TNF 8406994 233100 These data suggest that , in vivo , the and IL-1 alpha produced by cancer cells and other cells may *induce* [Mn-SOD] in vascular endothelial cells as well as other host tissues , resulting in release of a relatively large amount of this protein into the serum . Positive_regulation SOD1 TNF 8440412 213306 Interleukin-1 (IL-1) and selectively *induce* mitochondrial manganese [superoxide dismutase] ( MnSOD ) production in various cell types . Positive_regulation SOD1 TNF 8568353 340627 These data suggest that in vivo the produced by cancer cells may *induce* [Mn-SOD] in vascular endothelial cells , resulting in release of a relatively large amount of this protein into the serum . Positive_regulation SOD1 TNF 8817062 384547 We compared *induction* of manganese [superoxide dismutase] ( MnSOD ) by asbestos fibers and using cultured human mesothelial cells . Positive_regulation SOD1 TNF 8857257 388303 To determine whether lipopolysaccharide (LPS) and are *involved* in the induction of [superoxide dismutase (SOD)] in gingival tissue , we examined their effect on induction of SOD isozymes in cultured normal ( NGF ) and phenytoin induced hyperplastic ( PHF ) gingival fibroblasts . Positive_regulation SOD1 TNF 8885330 391090 Furthermore , [SOD] was *inducible* by in L929 cells , but not in L929.12 cells . Positive_regulation SOD1 TNF 9038369 415535 IL-1beta and both *stimulated* specifically [Mn-SOD] gene expression in a time dependent manner . Positive_regulation SOD1 TNF 9038369 415541 rapidly *induced* [Mn-SOD] gene expression while IL-1beta was a strong but slow inducer of this gene . Positive_regulation SOD1 TNF 9038369 415553 These results suggest that IL-1beta and *regulate* [Mn-SOD] gene transcription by different pathways . Positive_regulation SOD1 TNF 9062943 418021 *induces* expression of a Ca ( 2+ ) -binding protein and [Mn-superoxide dismutase] ; Positive_regulation SOD1 TNF 9114748 426190 Interleukin-1 alpha and *enhanced* both the [SOD] activity and protein level of Mn SOD , while these cytokines had no effect on Cu-Zn SOD protein levels in cultured human keratinocytes after incubation for 24 h . Positive_regulation SOD1 TNF 9215812 441823 The manganese containing mitochondrial [superoxide dismutase] ( MnSOD ) is *induced* by and protects against the necrotic effect of this cytokine . Positive_regulation SOD1 TNF 9651816 515580 Interferon-gamma dependent *induction* of manganese [superoxide dismutase] activity of SV40 transformed human keratinocytes by anti-Fas antibody and by . Positive_regulation SOD1 TNF 9651816 515603 These results indicate that the stimulation of Fas antigen or receptor *increases* [Mn-SOD] activity of SVHK cells in the presence of IFN-gamma and that TPA augments the process through the activation of protein kinase C . Positive_regulation SOD1 TNF 9751273 533538 Linoleic acid and *increase* manganese [superoxide dismutase] activity in intestinal cells . Positive_regulation SOD2 ABCA12 10682609 478627 In the tests of inhibition and prevention of tumor , could significantly inhibit the grouth of the two kinds of tumor , and *increase* the activity of [superoxide dismutage (SOD)] and decrease the contents of Malonyldialdehyde ( MDA ) . Positive_regulation SOD2 ARSA 14504662 1144684 NO-ASA , but not , *caused* an upregulation of [SOD] and GPx mRNA in gastric mucosa with or without sensory denervation . Positive_regulation SOD2 ARSA 25069161 2953782 Exogenous and GSH *enhanced* [SOD] , APX , and GR activities , increased endogenous AsA and GSH contents , and reduced those of H2O2 and MDA in the chloroplasts of both cultivars under salt stress ( 200 mM NaCl ) , but the effects were significantly more pronounced in cv. Pokkali . Positive_regulation SOD2 EPHB2 16966488 1627824 Phosphorylation of led to an activation of NFkappaB , as indicated by increased p50 subunit expression in nuclear extracts , and *increased* mRNA levels of the antioxidant enzyme [manganese-superoxide dismutase] ( MnSOD ) . Positive_regulation SOD2 FOXO1 15492127 1321461 IFN-gamma-driven expression of tryptophan catabolism by CTLA-4-immunoglobulin is made possible through the concomitant activation of the transcription factor FOXO3a , *induction* of the [superoxide dismutase] gene , and prevention of peroxynitrite formation . Positive_regulation SOD2 FOXO1 17408630 1728355 directly *induces* the expression of p27 ( kip1 ) and manganese [superoxide dismutase] ( MnSOD ) . Positive_regulation SOD2 FOXO1 19426753 2090218 overexpression could not *prevent* aging induced reduction in catalase , [CuZu-SOD] , and Mn-SOD mRNA in skeletal muscle . Positive_regulation SOD2 IL1B 10076538 560586 also *increased* cytosolic [Cu/Zn-superoxide dismutase (SOD)] and mitochondrial Mn-SOD in RINm5F cells . Positive_regulation SOD2 IL1B 10359573 619102 The production of reactive oxygen species and endogenous TNF-alpha and induced by exercise *leads* to the activation of [Mn-SOD] , which plays major roles in the acquisition of biphasic cardioprotection against ischemia/reperfusion injury in rats . Positive_regulation SOD2 IL1B 10492402 646578 An intronic NF-kappaB element is essential for *induction* of the human manganese [superoxide dismutase] gene by tumor necrosis factor-alpha and . Positive_regulation SOD2 IL1B 10903806 713229 When added together , p38i and MEKi decreased IL-1 beta induced nitrite production over 24 hours by 60 % , but did not affect *induced* manganese [superoxide dismutase] ( MnSOD ) mRNA expression . Positive_regulation SOD2 IL1B 11015290 737498 We conclude that the induction and activation of [Mn-SOD] , *mediated* by TNF-alpha and after IP , plays an important role in the acquisition of late-phase cardioprotection against ischaemia/reperfusion injury in rats . Positive_regulation SOD2 IL1B 11860476 893736 The evidence presented supports the view that this is secondary to the stress induced increase in IL-1beta concentration , as *increased* activity of [superoxide dismutase] and increased reactive oxygen species accumulation in hippocampus in vitro . Positive_regulation SOD2 IL1B 1533363 186500 *increases* the activity of [superoxide dismutase] in rat pancreatic islets . Positive_regulation SOD2 IL1B 18291685 1924865 In parallel , markedly *enhanced* Mn [SOD] and GPX gene expressions , but decreased Cu/Zn SOD , EC SOD and CAT gene expressions . Positive_regulation SOD2 IL1B 18559338 1959161 *Induction* of [Mn-SOD] gene expression by the proinflammatory cytokine is mediated through a complex intronic enhancer element . Positive_regulation SOD2 IL1B 7515058 257107 While and interleukin-6 *induced* [manganese-superoxide dismutase] gene expression , they slightly suppressed catalase gene expression in rat hepatocytes . Positive_regulation SOD2 IL1B 7539260 306996 We presently investigated the effects of pyrrolidine dithiocarbamate ( PDTC ) , a potent inhibitor of nuclear factor kappa B (NF-kappa B) , on the *induction* of nitric oxide synthase ( iNOS ) and manganese [superoxide dismutase] ( MnSOD ) mRNAs by in insulin producing RIN cells . Positive_regulation SOD2 IL1B 8719114 343863 *induces* the expression of hsp70 , heme oxygenase and [Mn-SOD] in FACS purified rat islet beta-cells , but not in alpha-cells . Positive_regulation SOD2 IL1B 9038369 415538 and TNF-alpha both *stimulated* specifically [Mn-SOD] gene expression in a time dependent manner . Positive_regulation SOD2 IL1B 9038369 415544 TNF-alpha rapidly *induced* [Mn-SOD] gene expression while was a strong but slow inducer of this gene . Positive_regulation SOD2 IL1B 9038369 415556 These results suggest that and TNF-alpha *regulate* [Mn-SOD] gene transcription by different pathways . Positive_regulation SOD2 IL1B 9372929 464427 Tumor necrosis factor alpha and *regulate* the murine manganese [superoxide dismutase] gene through a complex intronic enhancer involving C/EBP-beta and NF-kappaB . Positive_regulation SOD2 LBP 21077258 2419194 also played a significant role in the recovery of serum testosterone levels , *increased* [superoxide dismutase] activity , decreased malondialdehyde levels , promoted oxidative balance and rescued testicular DNA damage . Positive_regulation SOD2 LBP 24174357 2860263 At the same time , significantly decreased MDA content , and *increased* [SOD] , GSH-Px , CAT , LDH activities in ischemic reperfusion brain . Positive_regulation SOD2 OSR1 24078262 2867248 Moreover , markedly decreased MDA content , and *increased* [SOD] , GSH-Px activities . Positive_regulation SOD2 PGC 21054343 2376354 Reducing expression also *led* to reduced mRNA expression levels of uncoupling protein 1 , 2 ( UCP1 and UCP2 ) and [superoxide dismutase] 2 . Positive_regulation SOD2 TNF 10359573 619101 The production of reactive oxygen species and endogenous and IL-1beta induced by exercise *leads* to the activation of [Mn-SOD] , which plays major roles in the acquisition of biphasic cardioprotection against ischemia/reperfusion injury in rats . Positive_regulation SOD2 TNF 10492402 646577 An intronic NF-kappaB element is essential for *induction* of the human manganese [superoxide dismutase] gene by and interleukin-1beta . Positive_regulation SOD2 TNF 10760955 683684 A NF-kappaB p65 subunit is indispensable for activating manganese [superoxide: dismutase] gene transcription *mediated* by . Positive_regulation SOD2 TNF 10760955 683688 Expression of the manganese [superoxide dismutase] ( Mn-SOD ) is *induced* by , interleukin-1 (IL-1) , and lipopolysaccharide (LPS) . Positive_regulation SOD2 TNF 10760955 683699 This report describes the minimal promoter region of the Mn-SOD gene and investigates the cis acting elements and trans acting factors responsible for *induced* [Mn-SOD] gene expression . Positive_regulation SOD2 TNF 10760955 683724 These results show that a NF-kappaB p65 subunit is mainly involved in the molecular mechanisms controlling *mediated* [Mn-SOD] gene transcription . Positive_regulation SOD2 TNF 10924720 718400 The [Mn-SOD] activity was strongly *up-regulated* by and IL-1alpha and moderately by IFN-gamma . Positive_regulation SOD2 TNF 11015290 737497 We conclude that the induction and activation of [Mn-SOD] , *mediated* by and IL-1beta after IP , plays an important role in the acquisition of late-phase cardioprotection against ischaemia/reperfusion injury in rats . Positive_regulation SOD2 TNF 11675473 873376 *increased* manganese-SOD ( Mn-SOD ) mRNA level and [Mn-SOD] activity in a dose dependent manner in ESC . Positive_regulation SOD2 TNF 11675473 873379 *had* no effect on [copper-zinc-SOD] ( Cu , Zn-SOD ) expression in either type of cell . Positive_regulation SOD2 TNF 11675473 873385 Incubation of ESC with actinomycin D , an RNA synthesis inhibitor , blocked *induced* [Mn-SOD] mRNA expression , but cycloheximide , a protein synthesis inhibitor , had no effect . Positive_regulation SOD2 TNF 11675473 873388 H7 , an inhibitor of protein kinase C ( PKC ) , also inhibited *stimulated* [Mn-SOD] mRNA expression in both types of cells . Positive_regulation SOD2 TNF 11675473 873391 These findings suggest that *induced* [Mn-SOD] expression is regulated at the transcription level and mediated by PKC dependent phosphorylation and that de-novo protein synthesis is not required for the TNFalpha effect . Positive_regulation SOD2 TNF 11675473 873394 In summary , *induces* [Mn-SOD] expression in human ESC . Positive_regulation SOD2 TNF 12161520 971940 Nuclear factor-kappa B is required for *induced* manganese [superoxide dismutase] expression in human endometrial stromal cells . Positive_regulation SOD2 TNF 12161520 971943 We recently found that manganese superoxide dismutase ( Mn-SOD ) is up-regulated by at the transcription level in human endometrial stromal cells ( ESC ) and that TNF alpha induced [Mn-SOD] expression is *mediated* by protein kinase C ( PKC ) -dependent phosphorylation . Positive_regulation SOD2 TNF 12161520 971948 This study was undertaken to investigate whether nuclear factor-kappa B (NF-kappa B) , a transcription factor , is involved in [Mn-SOD] *induction* by or PKC in human ESC . Positive_regulation SOD2 TNF 12161520 971963 and TPA significantly *increased* Mn-SOD activities and [Mn-SOD] mRNA levels , and those effects were completely inhibited by MG132 and SN50 . Positive_regulation SOD2 TNF 12161520 971966 In conclusion , the present study showed the involvement of NF-kappa B in [Mn-SOD] *induction* by or PKC in human ESC . Positive_regulation SOD2 TNF 12684509 1099798 Role of the intronic enhancer in mediated *induction* of manganous [superoxide dismutase] . Positive_regulation SOD2 TNF 12684509 1099807 These assays demonstrate that Sp1 and nuclear factor (NF)-kappaB p65 are required for [Mn-SOD] *induction* by . Positive_regulation SOD2 TNF 1311566 178948 *Induction* of [Mn-superoxide dismutase] by , interleukin-1 and interleukin-6 in human hepatoma cells . Positive_regulation SOD2 TNF 1311566 179014 Both and IL-1 *enhanced* the [Mn-SOD] production to the level of 30- to 40-fold . Positive_regulation SOD2 TNF 1313774 182490 *induces* synthesis of manganese [superoxide dismutase] ( MnSOD ) . Positive_regulation SOD2 TNF 1320006 190072 activates nuclear factor kappa B and *induces* manganous [superoxide dismutase] and phosphodiesterase mRNA in human papillary thyroid carcinoma cells . Positive_regulation SOD2 TNF 1427594 202450 at a low dose ( 10 U/ml ) *stimulated* production of prostaglandin E2 , [Mn-superoxide dismutase] , interleukin (IL)-6 and IL-8 by glioblastoma cells . Positive_regulation SOD2 TNF 1445297 205185 Cell killing and *induction* of manganous [superoxide dismutase] by is mediated by lipoxygenase metabolites of arachidonic acid . Positive_regulation SOD2 TNF 1445297 205188 Our data reveal that *induction* of manganous [superoxide dismutase] ( MnSOD ) is also dependent upon lipoxygenase activity . Positive_regulation SOD2 TNF 1551878 184070 , IL-1 alpha , and IFN-gamma *stimulated* the [Mn-SOD] activity , as previously known , and these responses were reduced by TGF-beta . Positive_regulation SOD2 TNF 1568640 186993 These facts suggest that secretion from the infarcted area *resulted* in the production of [Mn-SOD] and that the induced Mn-SOD was released from myocytes into serum through damaged membranes , resulting in the late elevation . Positive_regulation SOD2 TNF 16644673 1553112 Using reduced MitoTracker Red probe , we confirmed that *increased* mitochondrial ROS production , which was suppressed by overexpression of either uncoupling protein-1 (UCP)-1 or manganese [superoxide dismutase] ( MnSOD ) . Positive_regulation SOD2 TNF 1668725 177706 *induces* manganese containing [superoxide dismutase] ( MnSOD ) which also uses O2- to produce cytotoxic concentrations of hydrogen peroxide . Positive_regulation SOD2 TNF 1850207 155524 *increases* [Mn-SOD] expression : protection against oxidant injury . Positive_regulation SOD2 TNF 1850207 155530 significantly *increased* [Mn-SOD] activity and mRNA in a dose-and time dependent manner . Positive_regulation SOD2 TNF 1850207 155533 Our results suggest that the *induction* of [Mn-SOD] by in pulmonary adenocarcinoma cells is pretranslationally mediated and that increasing Mn-SOD activity with TNF-alpha confers protection against O2 radicals . Positive_regulation SOD2 TNF 18761070 1975437 Pretreatment with CGX significantly restored the reduction of catalase activity and glutathione ( GSH ) content , but not [superoxide dismutase (SOD)] activity , and it *inhibited* the CCl ( 4 ) -induced high expression of iNOS and in hepatic tissue . Positive_regulation SOD2 TNF 20112906 2206328 [SOD] and GPx expressions decreased ( p < 0.001 ) but that of *increased* significantly ( P < 0.001 ) in FT rats with respect to FC and NFT animals . Positive_regulation SOD2 TNF 20884819 2357067 Positive immunolabelings for interleukin-6 , *inducible* nitric oxide synthase , and dimeric copper- and zinc containing [superoxide dismutase] were observed mainly in the inflammatory cells in the lesions ; Positive_regulation SOD2 TNF 21040696 2376292 After edaravone treatment , levels of MDA , IL-6 , and hydroproline decreased , but [SOD] and GSH-PX activity in lung tissue and BALF *increased* . Positive_regulation SOD2 TNF 21166155 1506560 significantly decreased the release of LDH ( P < 0.05 ) and *increased* the activity of [Mn-SOD] in the myocardium ( P < 0.05 ) . Positive_regulation SOD2 TNF 21169125 2419430 Furthermore , experiments with small interfering RNA in endothelial cells revealed that decreased [SOD2] activity increased *mediated* cellular oxidant levels compared with controls . Positive_regulation SOD2 TNF 2222450 144318 *Stimulation* of [Mn-superoxide dismutase] expression by : quantitative determination of Mn-SOD protein levels in TNF-resistant and sensitive cells by ELISA . Positive_regulation SOD2 TNF 2260678 146437 Molecular basis for *induced* increase in pulmonary [superoxide dismutase] activities . Positive_regulation SOD2 TNF 22753593 2644525 Both BRCA1- and DAB2 targeting siRNA increased *induced* NF-?B activity and mRNA expression of NF-?B dependent target gene [SOD2] relative to nontargeting siRNA , suggesting that both proteins repress proinflammatory signaling . Positive_regulation SOD2 TNF 23895132 2825678 However , comparing to the model rabbits , levels of , IL-1ß and MDA decreased significantly and serum [SOD] activity *increased* , gene and protein expressions of E-sel , ICAM-1 , VCAM-1 and MCP-1 in aortas decreased significantly with the treatment of kaempferol . Positive_regulation SOD2 TNF 2406241 128184 We have demonstrated a dramatic induction of manganese [superoxide dismutase] ( Mn-SOD ) mRNA levels in *response* to lipopolysaccharide (LPS) , interleukin-1 , and in pulmonary epithelial cells . Positive_regulation SOD2 TNF 2547375 115559 *Induction* of manganese [superoxide dismutase] by in human breast cancer MCF-7 cell line and its TNF-resistant variant . Positive_regulation SOD2 TNF 2547375 115562 TNF induced more mitochondrial manganese SOD ( SODm ) in MCF-7 than in Tnf-1000 whereas there appeared to be no significant *induction* of cytosolic copper/zinc [SOD] ( SODc ) by in both MCF-7 and Tnf-1000 cell lines . Positive_regulation SOD2 TNF 3263703 101265 *Induction* of manganous [superoxide dismutase] by : possible protective mechanism . Positive_regulation SOD2 TNF 7760346 307919 Leukemia inhibitory factor and *induce* manganese [superoxide dismutase] and protect rabbit hearts from reperfusion injury . Positive_regulation SOD2 TNF 8260539 238834 Cytotoxicity and manganese [superoxide dismutase] *induction* by and ionizing radiation in MCF-7 human breast carcinoma cells . Positive_regulation SOD2 TNF 8292376 248056 Manganous [superoxide dismutase] ( MnSOD ) gene expression is *stimulated* by endotoxin , , and interleukin-1 , agents thought to cause cellular damage through intracellular generation of reactive oxygen species . Positive_regulation SOD2 TNF 8317554 222997 Both manganese [SOD] and copper , zinc SOD activities were significantly *induced* by paraquat , interleukin-1 , , adriamycin , and bleomycin in lymphocytes and neutrophils from asymptomatic non aged adults , whereas neither activity was induced in aged individuals . Positive_regulation SOD2 TNF 8406994 233102 These data suggest that , in vivo , the and IL-1 alpha produced by cancer cells and other cells may *induce* [Mn-SOD] in vascular endothelial cells as well as other host tissues , resulting in release of a relatively large amount of this protein into the serum . Positive_regulation SOD2 TNF 8440412 213308 Interleukin-1 (IL-1) and selectively *induce* mitochondrial manganese [superoxide dismutase] ( MnSOD ) production in various cell types . Positive_regulation SOD2 TNF 8568353 340628 These data suggest that in vivo the produced by cancer cells may *induce* [Mn-SOD] in vascular endothelial cells , resulting in release of a relatively large amount of this protein into the serum . Positive_regulation SOD2 TNF 8817062 384548 We compared *induction* of manganese [superoxide dismutase] ( MnSOD ) by asbestos fibers and using cultured human mesothelial cells . Positive_regulation SOD2 TNF 8857257 388304 To determine whether lipopolysaccharide (LPS) and are *involved* in the induction of [superoxide dismutase (SOD)] in gingival tissue , we examined their effect on induction of SOD isozymes in cultured normal ( NGF ) and phenytoin induced hyperplastic ( PHF ) gingival fibroblasts . Positive_regulation SOD2 TNF 8885330 391091 Furthermore , [SOD] was *inducible* by in L929 cells , but not in L929.12 cells . Positive_regulation SOD2 TNF 9038369 415537 IL-1beta and both *stimulated* specifically [Mn-SOD] gene expression in a time dependent manner . Positive_regulation SOD2 TNF 9038369 415543 rapidly *induced* [Mn-SOD] gene expression while IL-1beta was a strong but slow inducer of this gene . Positive_regulation SOD2 TNF 9038369 415555 These results suggest that IL-1beta and *regulate* [Mn-SOD] gene transcription by different pathways . Positive_regulation SOD2 TNF 9062943 418022 *induces* expression of a Ca ( 2+ ) -binding protein and [Mn-superoxide dismutase] ; Positive_regulation SOD2 TNF 9114748 426192 Interleukin-1 alpha and *enhanced* both the [SOD] activity and protein level of Mn SOD , while these cytokines had no effect on Cu-Zn SOD protein levels in cultured human keratinocytes after incubation for 24 h . Positive_regulation SOD2 TNF 9215812 441824 The manganese containing mitochondrial [superoxide dismutase] ( MnSOD ) is *induced* by and protects against the necrotic effect of this cytokine . Positive_regulation SOD2 TNF 9651816 515582 Interferon-gamma dependent *induction* of manganese [superoxide dismutase] activity of SV40 transformed human keratinocytes by anti-Fas antibody and by . Positive_regulation SOD2 TNF 9651816 515605 These results indicate that the stimulation of Fas antigen or receptor *increases* [Mn-SOD] activity of SVHK cells in the presence of IFN-gamma and that TPA augments the process through the activation of protein kinase C . Positive_regulation SOD2 TNF 9751273 533539 Linoleic acid and *increase* manganese [superoxide dismutase] activity in intestinal cells . Positive_regulation SOD3 ABCA12 10682609 478629 In the tests of inhibition and prevention of tumor , could significantly inhibit the grouth of the two kinds of tumor , and *increase* the activity of [superoxide dismutage (SOD)] and decrease the contents of Malonyldialdehyde ( MDA ) . Positive_regulation SOD3 ARSA 14504662 1144685 , but not ASA , *caused* an upregulation of [SOD] and GPx mRNA in gastric mucosa with or without sensory denervation . Positive_regulation SOD3 ARSA 25069161 2953783 Exogenous and GSH *enhanced* [SOD] , APX , and GR activities , increased endogenous AsA and GSH contents , and reduced those of H2O2 and MDA in the chloroplasts of both cultivars under salt stress ( 200 mM NaCl ) , but the effects were significantly more pronounced in cv. Pokkali . Positive_regulation SOD3 EPHB2 16966488 1627825 Phosphorylation of led to an activation of NFkappaB , as indicated by increased p50 subunit expression in nuclear extracts , and *increased* mRNA levels of the antioxidant enzyme [manganese-superoxide dismutase] ( MnSOD ) . Positive_regulation SOD3 FOXO1 15492127 1321476 IFN-gamma-driven expression of tryptophan catabolism by CTLA-4-immunoglobulin is made possible through the concomitant activation of the transcription factor FOXO3a , *induction* of the [superoxide dismutase] gene , and prevention of peroxynitrite formation . Positive_regulation SOD3 FOXO1 17408630 1728356 directly *induces* the expression of p27 ( kip1 ) and manganese [superoxide dismutase] ( MnSOD ) . Positive_regulation SOD3 FOXO1 19426753 2090219 overexpression could not *prevent* aging induced reduction in catalase , [CuZu-SOD] , and Mn-SOD mRNA in skeletal muscle . Positive_regulation SOD3 IL1B 10076538 560587 also *increased* cytosolic Cu/Zn-superoxide dismutase (SOD) and mitochondrial [Mn-SOD] in RINm5F cells . Positive_regulation SOD3 IL1B 10359573 619104 The production of reactive oxygen species and endogenous TNF-alpha and induced by exercise *leads* to the activation of [Mn-SOD] , which plays major roles in the acquisition of biphasic cardioprotection against ischemia/reperfusion injury in rats . Positive_regulation SOD3 IL1B 10492402 646580 An intronic NF-kappaB element is essential for *induction* of the human manganese [superoxide dismutase] gene by tumor necrosis factor-alpha and . Positive_regulation SOD3 IL1B 10903806 713230 When added together , p38i and MEKi decreased IL-1 beta induced nitrite production over 24 hours by 60 % , but did not affect *induced* manganese [superoxide dismutase] ( MnSOD ) mRNA expression . Positive_regulation SOD3 IL1B 11015290 737500 We conclude that the induction and activation of [Mn-SOD] , *mediated* by TNF-alpha and after IP , plays an important role in the acquisition of late-phase cardioprotection against ischaemia/reperfusion injury in rats . Positive_regulation SOD3 IL1B 11860476 893737 The evidence presented supports the view that this is secondary to the stress induced increase in IL-1beta concentration , as *increased* activity of [superoxide dismutase] and increased reactive oxygen species accumulation in hippocampus in vitro . Positive_regulation SOD3 IL1B 1533363 186501 *increases* the activity of [superoxide dismutase] in rat pancreatic islets . Positive_regulation SOD3 IL1B 18291685 1924866 In parallel , markedly *enhanced* Mn [SOD] and GPX gene expressions , but decreased Cu/Zn SOD , EC SOD and CAT gene expressions . Positive_regulation SOD3 IL1B 18559338 1959162 *Induction* of [Mn-SOD] gene expression by the proinflammatory cytokine is mediated through a complex intronic enhancer element . Positive_regulation SOD3 IL1B 7515058 257109 While and interleukin-6 *induced* [manganese-superoxide dismutase] gene expression , they slightly suppressed catalase gene expression in rat hepatocytes . Positive_regulation SOD3 IL1B 7539260 306997 We presently investigated the effects of pyrrolidine dithiocarbamate ( PDTC ) , a potent inhibitor of nuclear factor kappa B (NF-kappa B) , on the *induction* of nitric oxide synthase ( iNOS ) and manganese [superoxide dismutase] ( MnSOD ) mRNAs by in insulin producing RIN cells . Positive_regulation SOD3 IL1B 8719114 343864 *induces* the expression of hsp70 , heme oxygenase and [Mn-SOD] in FACS purified rat islet beta-cells , but not in alpha-cells . Positive_regulation SOD3 IL1B 9038369 415540 and TNF-alpha both *stimulated* specifically [Mn-SOD] gene expression in a time dependent manner . Positive_regulation SOD3 IL1B 9038369 415546 TNF-alpha rapidly *induced* [Mn-SOD] gene expression while was a strong but slow inducer of this gene . Positive_regulation SOD3 IL1B 9038369 415558 These results suggest that and TNF-alpha *regulate* [Mn-SOD] gene transcription by different pathways . Positive_regulation SOD3 IL1B 9372929 464428 Tumor necrosis factor alpha and *regulate* the murine manganese [superoxide dismutase] gene through a complex intronic enhancer involving C/EBP-beta and NF-kappaB . Positive_regulation SOD3 LBP 21077258 2419195 also played a significant role in the recovery of serum testosterone levels , *increased* [superoxide dismutase] activity , decreased malondialdehyde levels , promoted oxidative balance and rescued testicular DNA damage . Positive_regulation SOD3 LBP 24174357 2860264 At the same time , significantly decreased MDA content , and *increased* [SOD] , GSH-Px , CAT , LDH activities in ischemic reperfusion brain . Positive_regulation SOD3 OSR1 24078262 2867250 Moreover , markedly decreased MDA content , and *increased* [SOD] , GSH-Px activities . Positive_regulation SOD3 PGC 21054343 2376355 Reducing expression also *led* to reduced mRNA expression levels of uncoupling protein 1 , 2 ( UCP1 and UCP2 ) and [superoxide dismutase] 2 . Positive_regulation SOD3 TNF 10359573 619103 The production of reactive oxygen species and endogenous and IL-1beta induced by exercise *leads* to the activation of [Mn-SOD] , which plays major roles in the acquisition of biphasic cardioprotection against ischemia/reperfusion injury in rats . Positive_regulation SOD3 TNF 10492402 646579 An intronic NF-kappaB element is essential for *induction* of the human manganese [superoxide dismutase] gene by and interleukin-1beta . Positive_regulation SOD3 TNF 10760955 683685 A NF-kappaB p65 subunit is indispensable for activating manganese [superoxide: dismutase] gene transcription *mediated* by . Positive_regulation SOD3 TNF 10760955 683690 Expression of the manganese [superoxide dismutase] ( Mn-SOD ) is *induced* by , interleukin-1 (IL-1) , and lipopolysaccharide (LPS) . Positive_regulation SOD3 TNF 10760955 683700 This report describes the minimal promoter region of the Mn-SOD gene and investigates the cis acting elements and trans acting factors responsible for *induced* [Mn-SOD] gene expression . Positive_regulation SOD3 TNF 10760955 683725 These results show that a NF-kappaB p65 subunit is mainly involved in the molecular mechanisms controlling *mediated* [Mn-SOD] gene transcription . Positive_regulation SOD3 TNF 10924720 718403 The [Mn-SOD] activity was strongly *up-regulated* by and IL-1alpha and moderately by IFN-gamma . Positive_regulation SOD3 TNF 11015290 737499 We conclude that the induction and activation of [Mn-SOD] , *mediated* by and IL-1beta after IP , plays an important role in the acquisition of late-phase cardioprotection against ischaemia/reperfusion injury in rats . Positive_regulation SOD3 TNF 11675473 873377 *increased* [manganese-SOD] ( Mn-SOD ) mRNA level and Mn-SOD activity in a dose dependent manner in ESC . Positive_regulation SOD3 TNF 11675473 873380 *had* no effect on [copper-zinc-SOD] ( Cu , Zn-SOD ) expression in either type of cell . Positive_regulation SOD3 TNF 11675473 873386 Incubation of ESC with actinomycin D , an RNA synthesis inhibitor , blocked *induced* [Mn-SOD] mRNA expression , but cycloheximide , a protein synthesis inhibitor , had no effect . Positive_regulation SOD3 TNF 11675473 873389 H7 , an inhibitor of protein kinase C ( PKC ) , also inhibited *stimulated* [Mn-SOD] mRNA expression in both types of cells . Positive_regulation SOD3 TNF 11675473 873392 These findings suggest that *induced* [Mn-SOD] expression is regulated at the transcription level and mediated by PKC dependent phosphorylation and that de-novo protein synthesis is not required for the TNFalpha effect . Positive_regulation SOD3 TNF 11675473 873395 In summary , *induces* [Mn-SOD] expression in human ESC . Positive_regulation SOD3 TNF 12161520 971941 Nuclear factor-kappa B is required for *induced* manganese [superoxide dismutase] expression in human endometrial stromal cells . Positive_regulation SOD3 TNF 12161520 971944 We recently found that manganese superoxide dismutase ( Mn-SOD ) is up-regulated by at the transcription level in human endometrial stromal cells ( ESC ) and that TNF alpha induced [Mn-SOD] expression is *mediated* by protein kinase C ( PKC ) -dependent phosphorylation . Positive_regulation SOD3 TNF 12161520 971951 This study was undertaken to investigate whether nuclear factor-kappa B (NF-kappa B) , a transcription factor , is involved in [Mn-SOD] *induction* by or PKC in human ESC . Positive_regulation SOD3 TNF 12161520 971964 and TPA significantly *increased* [Mn-SOD] activities and Mn-SOD mRNA levels , and those effects were completely inhibited by MG132 and SN50 . Positive_regulation SOD3 TNF 12161520 971967 In conclusion , the present study showed the involvement of NF-kappa B in [Mn-SOD] *induction* by or PKC in human ESC . Positive_regulation SOD3 TNF 12684509 1099799 Role of the intronic enhancer in *mediated* induction of manganous [superoxide dismutase] . Positive_regulation SOD3 TNF 12684509 1099810 These assays demonstrate that Sp1 and nuclear factor (NF)-kappaB p65 are required for [Mn-SOD] *induction* by . Positive_regulation SOD3 TNF 1311566 178976 *Induction* of [Mn-superoxide dismutase] by , interleukin-1 and interleukin-6 in human hepatoma cells . Positive_regulation SOD3 TNF 1311566 179016 Both and IL-1 *enhanced* the [Mn-SOD] production to the level of 30- to 40-fold . Positive_regulation SOD3 TNF 1313774 182491 *induces* synthesis of manganese [superoxide dismutase] ( MnSOD ) . Positive_regulation SOD3 TNF 1320006 190073 activates nuclear factor kappa B and *induces* manganous [superoxide dismutase] and phosphodiesterase mRNA in human papillary thyroid carcinoma cells . Positive_regulation SOD3 TNF 1427594 202451 at a low dose ( 10 U/ml ) *stimulated* production of prostaglandin E2 , [Mn-superoxide dismutase] , interleukin (IL)-6 and IL-8 by glioblastoma cells . Positive_regulation SOD3 TNF 1445297 205186 Cell killing and *induction* of manganous [superoxide dismutase] by is mediated by lipoxygenase metabolites of arachidonic acid . Positive_regulation SOD3 TNF 1445297 205189 Our data reveal that *induction* of manganous [superoxide dismutase] ( MnSOD ) is also dependent upon lipoxygenase activity . Positive_regulation SOD3 TNF 1551878 184073 , IL-1 alpha , and IFN-gamma *stimulated* the [Mn-SOD] activity , as previously known , and these responses were reduced by TGF-beta . Positive_regulation SOD3 TNF 1568640 186994 These facts suggest that secretion from the infarcted area *resulted* in the production of [Mn-SOD] and that the induced Mn-SOD was released from myocytes into serum through damaged membranes , resulting in the late elevation . Positive_regulation SOD3 TNF 16644673 1553113 Using reduced MitoTracker Red probe , we confirmed that *increased* mitochondrial ROS production , which was suppressed by overexpression of either uncoupling protein-1 (UCP)-1 or manganese [superoxide dismutase] ( MnSOD ) . Positive_regulation SOD3 TNF 1668725 177707 *induces* manganese containing [superoxide dismutase] ( MnSOD ) which also uses O2- to produce cytotoxic concentrations of hydrogen peroxide . Positive_regulation SOD3 TNF 1850207 155525 *increases* [Mn-SOD] expression : protection against oxidant injury . Positive_regulation SOD3 TNF 1850207 155531 significantly *increased* [Mn-SOD] activity and mRNA in a dose-and time dependent manner . Positive_regulation SOD3 TNF 1850207 155534 Our results suggest that the *induction* of [Mn-SOD] by in pulmonary adenocarcinoma cells is pretranslationally mediated and that increasing Mn-SOD activity with TNF-alpha confers protection against O2 radicals . Positive_regulation SOD3 TNF 18761070 1975439 Pretreatment with CGX significantly restored the reduction of catalase activity and glutathione ( GSH ) content , but not [superoxide dismutase (SOD)] activity , and it *inhibited* the CCl ( 4 ) -induced high expression of iNOS and in hepatic tissue . Positive_regulation SOD3 TNF 20112906 2206329 [SOD] and GPx expressions decreased ( p < 0.001 ) but that of *increased* significantly ( P < 0.001 ) in FT rats with respect to FC and NFT animals . Positive_regulation SOD3 TNF 20884819 2357068 Positive immunolabelings for interleukin-6 , *inducible* nitric oxide synthase , and dimeric copper- and zinc containing [superoxide dismutase] were observed mainly in the inflammatory cells in the lesions ; Positive_regulation SOD3 TNF 21040696 2376294 After edaravone treatment , levels of MDA , IL-6 , and hydroproline decreased , but [SOD] and GSH-PX activity in lung tissue and BALF *increased* . Positive_regulation SOD3 TNF 21166155 1506561 significantly decreased the release of LDH ( P < 0.05 ) and *increased* the activity of [Mn-SOD] in the myocardium ( P < 0.05 ) . Positive_regulation SOD3 TNF 2222450 144319 *Stimulation* of [Mn-superoxide dismutase] expression by : quantitative determination of Mn-SOD protein levels in TNF-resistant and sensitive cells by ELISA . Positive_regulation SOD3 TNF 2260678 146438 Molecular basis for *induced* increase in pulmonary [superoxide dismutase] activities . Positive_regulation SOD3 TNF 23895132 2825680 However , comparing to the model rabbits , levels of , IL-1ß and MDA decreased significantly and serum [SOD] activity *increased* , gene and protein expressions of E-sel , ICAM-1 , VCAM-1 and MCP-1 in aortas decreased significantly with the treatment of kaempferol . Positive_regulation SOD3 TNF 2406241 128212 We have demonstrated a dramatic induction of manganese [superoxide dismutase] ( Mn-SOD ) mRNA levels in *response* to lipopolysaccharide (LPS) , interleukin-1 , and in pulmonary epithelial cells . Positive_regulation SOD3 TNF 2547375 115560 *Induction* of manganese [superoxide dismutase] by in human breast cancer MCF-7 cell line and its TNF-resistant variant . Positive_regulation SOD3 TNF 2547375 115563 *induced* more mitochondrial manganese [SOD] ( SODm ) in MCF-7 than in Tnf-1000 whereas there appeared to be no significant induction of cytosolic copper/zinc SOD ( SODc ) by TNF in both MCF-7 and Tnf-1000 cell lines . Positive_regulation SOD3 TNF 3263703 101266 *Induction* of manganous [superoxide dismutase] by : possible protective mechanism . Positive_regulation SOD3 TNF 7760346 307921 Leukemia inhibitory factor and *induce* manganese [superoxide dismutase] and protect rabbit hearts from reperfusion injury . Positive_regulation SOD3 TNF 8260539 238835 Cytotoxicity and manganese [superoxide dismutase] *induction* by and ionizing radiation in MCF-7 human breast carcinoma cells . Positive_regulation SOD3 TNF 8292376 248084 Manganous [superoxide dismutase] ( MnSOD ) gene expression is *stimulated* by endotoxin , , and interleukin-1 , agents thought to cause cellular damage through intracellular generation of reactive oxygen species . Positive_regulation SOD3 TNF 8317554 223025 Both manganese [SOD] and copper , zinc SOD activities were significantly *induced* by paraquat , interleukin-1 , , adriamycin , and bleomycin in lymphocytes and neutrophils from asymptomatic non aged adults , whereas neither activity was induced in aged individuals . Positive_regulation SOD3 TNF 8406994 233104 These data suggest that , in vivo , the and IL-1 alpha produced by cancer cells and other cells may *induce* [Mn-SOD] in vascular endothelial cells as well as other host tissues , resulting in release of a relatively large amount of this protein into the serum . Positive_regulation SOD3 TNF 8440412 213310 Interleukin-1 (IL-1) and selectively *induce* mitochondrial manganese [superoxide dismutase] ( MnSOD ) production in various cell types . Positive_regulation SOD3 TNF 8568353 340629 These data suggest that in vivo the produced by cancer cells may *induce* [Mn-SOD] in vascular endothelial cells , resulting in release of a relatively large amount of this protein into the serum . Positive_regulation SOD3 TNF 8817062 384549 We compared *induction* of manganese [superoxide dismutase] ( MnSOD ) by asbestos fibers and using cultured human mesothelial cells . Positive_regulation SOD3 TNF 8857257 388305 To determine whether lipopolysaccharide (LPS) and are *involved* in the induction of [superoxide dismutase (SOD)] in gingival tissue , we examined their effect on induction of SOD isozymes in cultured normal ( NGF ) and phenytoin induced hyperplastic ( PHF ) gingival fibroblasts . Positive_regulation SOD3 TNF 8885330 391092 Furthermore , [SOD] was *inducible* by in L929 cells , but not in L929.12 cells . Positive_regulation SOD3 TNF 9038369 415539 IL-1beta and both *stimulated* specifically [Mn-SOD] gene expression in a time dependent manner . Positive_regulation SOD3 TNF 9038369 415545 rapidly *induced* [Mn-SOD] gene expression while IL-1beta was a strong but slow inducer of this gene . Positive_regulation SOD3 TNF 9038369 415557 These results suggest that IL-1beta and *regulate* [Mn-SOD] gene transcription by different pathways . Positive_regulation SOD3 TNF 9062943 418023 *induces* expression of a Ca ( 2+ ) -binding protein and [Mn-superoxide dismutase] ; Positive_regulation SOD3 TNF 9114748 426194 Interleukin-1 alpha and *enhanced* both the [SOD] activity and protein level of Mn SOD , while these cytokines had no effect on Cu-Zn SOD protein levels in cultured human keratinocytes after incubation for 24 h . Positive_regulation SOD3 TNF 9215812 441825 The manganese containing mitochondrial [superoxide dismutase] ( MnSOD ) is *induced* by and protects against the necrotic effect of this cytokine . Positive_regulation SOD3 TNF 9651816 515584 Interferon-gamma dependent *induction* of manganese [superoxide dismutase] activity of SV40 transformed human keratinocytes by anti-Fas antibody and by . Positive_regulation SOD3 TNF 9651816 515607 These results indicate that the stimulation of Fas antigen or receptor *increases* [Mn-SOD] activity of SVHK cells in the presence of IFN-gamma and that TPA augments the process through the activation of protein kinase C . Positive_regulation SOD3 TNF 9751273 533540 Linoleic acid and *increase* manganese [superoxide dismutase] activity in intestinal cells . Positive_regulation SORBS1 IL1B 11980855 934942 The in vitro studies suggest that [CAP37] induction is *regulated* by TNF-alpha and . Positive_regulation SORBS1 TNF 11980855 934941 The in vitro studies suggest that [CAP37] induction is *regulated* by and IL-1beta . Positive_regulation SORL1 APOB 24284991 2904590 Oxidised showed similar effects compared to carbamylated LDL but *caused* significantly lower [LR11] expression under chronic high shear stress . Positive_regulation SORL1 GGA1 17855360 1818110 Proper localization and activity of [sorLA] are *dependent* on functional interaction with and PACS-1 , adaptor proteins involved in protein transport to and from the trans-Golgi network . Positive_regulation SORL1 GGA2 17855360 1818108 Proper localization and activity of [sorLA] are *dependent* on functional interaction with and PACS-1 , adaptor proteins involved in protein transport to and from the trans-Golgi network . Positive_regulation SORL1 GGA3 17855360 1818109 Proper localization and activity of [sorLA] are *dependent* on functional interaction with and PACS-1 , adaptor proteins involved in protein transport to and from the trans-Golgi network . Positive_regulation SORL1 PACS1 17855360 1818111 Proper localization and activity of [sorLA] are *dependent* on functional interaction with GGA and , adaptor proteins involved in protein transport to and from the trans-Golgi network . Positive_regulation SORT1 EPHB2 23904453 2840116 Consistently , hepatic ERK signaling was activated in diabetic mice , whereas blocking signaling by an ERK inhibitor *increased* hepatic [Sort1] protein in mice . Positive_regulation SOS1 EPHB2 10537288 563189 Activation of by GnRHa occurred within 5 min , with the maximum occurring at 3 h and sustained until 24 h. GnRHa also activated ERK kinase ( mitogen activated protein/ERK kinase ) and *resulted* in an increase in phosphorylation of [son of sevenless (Sos)] , and Shc . Positive_regulation SOS1 EPHB2 9351826 466068 We demonstrate that ET-1 signaling elicits a negative feedback mechanism , modulating p21ras activity through *dependent* [Sos1] phosphorylation , findings which were confirmed using an adenovirus MEK construct . Positive_regulation SOS1 JAG1 23613664 2774639 As a corollary , we established that a BER pathway deficient E. coli strain induces [SOS] in *response* to sub-MIC . Positive_regulation SOS1 MAP2K6 8552085 347142 Expression of a dominant interfering mutant , in which lysine 97 was replaced with arginine ( MEK/K97R ) , *resulted* in an inhibition of insulin stimulated [SOS] and ERK phosphorylation , whereas expression of a constitutively active MEK mutant , in which serines 218 and 222 were replaced with glutamic acid ( MEK/EE ) , induced basal phosphorylation of both SOS and ERK . Positive_regulation SOS1 MMP28 22287334 2605786 [SOS] is associated with portal hypertension and is *caused* by oxidative damage to endothelial cells and induction . Positive_regulation SOS1 MMP7 22287334 2605801 [SOS] is associated with portal hypertension and is *caused* by oxidative damage to endothelial cells and induction . Positive_regulation SOS1 NOSTRIN 22751148 2634459 forms a complex with the GTPase Rac1 and its exchange factor [Sos1] and overexpression of NOSTRIN in cells *induces* Rac1 activation . Positive_regulation SOS1 PLAU 11266465 796868 complex *induced* tyrosine phosphorylation of focal adhesion kinase and Shc and sustained association of [Sos] with Shc , whereas uPA caused transient association of Sos with Shc . Positive_regulation SOS1 TNF 2646534 108718 It also increased the 2AA and *induced* [SOS] response by more than 300 % . Positive_regulation SOS2 EPHB2 10537288 563190 Activation of by GnRHa occurred within 5 min , with the maximum occurring at 3 h and sustained until 24 h. GnRHa also activated ERK kinase ( mitogen activated protein/ERK kinase ) and *resulted* in an increase in phosphorylation of [son of sevenless (Sos)] , and Shc . Positive_regulation SOS2 JAG1 23613664 2774640 As a corollary , we established that a BER pathway deficient E. coli strain induces [SOS] in *response* to sub-MIC . Positive_regulation SOS2 MAP2K6 8552085 347150 Expression of a dominant interfering mutant , in which lysine 97 was replaced with arginine ( MEK/K97R ) , *resulted* in an inhibition of insulin stimulated [SOS] and ERK phosphorylation , whereas expression of a constitutively active MEK mutant , in which serines 218 and 222 were replaced with glutamic acid ( MEK/EE ) , induced basal phosphorylation of both SOS and ERK . Positive_regulation SOS2 MMP28 22287334 2605808 [SOS] is associated with portal hypertension and is *caused* by oxidative damage to endothelial cells and induction . Positive_regulation SOS2 MMP7 22287334 2605823 [SOS] is associated with portal hypertension and is *caused* by oxidative damage to endothelial cells and induction . Positive_regulation SOS2 PLAU 11266465 796870 complex *induced* tyrosine phosphorylation of focal adhesion kinase and Shc and sustained association of [Sos] with Shc , whereas uPA caused transient association of Sos with Shc . Positive_regulation SOS2 TNF 2646534 108719 It also increased the 2AA and *induced* [SOS] response by more than 300 % . Positive_regulation SOST TNF 19292615 2114394 Significantly , TWEAK and *induced* the expression of the osteoblast differentiation inhibitor and [SOST] gene product , sclerostin . Positive_regulation SOST TNF 24446199 2901578 *upregulates* [sclerostin] expression in obese mice fed a high-fat diet . Positive_regulation SOST TNF 24446199 2901579 Sclerostin expression in MLO-Y4 osteocytes increased with TNF-a treatment , and *induced* [sclerostin] expression was blocked by the inhibition of NF-?B activation . Positive_regulation SOST TNF 24446199 2901580 These results support a model in which , in the context of obesity or other inflammatory diseases that increase the production of TNF-a , *upregulates* the expression of [sclerostin] through NF-?B signaling pathway , thus contributing to bone loss . Positive_regulation SOX18 EPHB2 23391722 2748217 Expression of mutant RAF1 ( S259A ) in ECs activated and *induced* [SOX18] and PROX1 expression , leading to increased commitment of venous ECs to the lymphatic fate . Positive_regulation SOX2 EPHB2 24188385 2890237 Co-culture with CM resulted in an increased resistance to Adriamycin and enhanced expressions of a-FP , MMP9 , ABCG2 , CD133 , and [SOX2] , as well as the *activation* of , AKT , WNT , and TGF-ß1 pathways . Positive_regulation SOX2 KRT38 16079156 1442598 Conversely , misexpression of Xfoxi1a suppresses [Sox2] and *induces* in the anterior neural plate . Positive_regulation SOX9 CHI3L1 16949314 1682516 *induced* both [SOX9] and type II collagen synthesis . Positive_regulation SOX9 EPHB2 20457810 2275622 We also show that fibronectin is required for the Pref-1 mediated inhibition of adipocyte differentiation , the *activation* of , and the upregulation of [Sox9] . Positive_regulation SOX9 TNF 18182117 1895188 Together , and atRA *diminished* transcript levels of cartilage matrix proteins and [Sox9] activity more than each factor alone . Positive_regulation SOX9 TNF 19144181 2079138 *induced* regulation of [Sox9] and NFkappaB activity was also U0126 insensitive . Positive_regulation SP1 CCND1 18367547 1912789 Nerve Growth factor regulation of in PC12 cells through a p21RAS extracellular signal regulated kinase pathway *requires* cooperative interactions between [Sp1] and nuclear factor-kappaB . Positive_regulation SP1 EPHB2 10751319 681504 Erk is capable of phosphorylating other mitogen-inducible transcription factors , e.g. , Elk and Sap , suggesting that may also *mediate* EGF dependent phosphorylation of [Sp1] . Positive_regulation SP1 EPHB2 11914583 925223 These results indicate that PMA treatment *induced* activation mainly through the Raf-MEK-ERK signaling pathway following induction of c-Jun expression , and the formation of the [c-Jun-Sp1] complex . Positive_regulation SP1 EPHB2 14597566 1187437 Helicobacter pylori stimulates host vascular endothelial growth factor-A ( vegf-A ) gene expression via dependent *activation* of [Sp1] and Sp3 . Positive_regulation SP1 EPHB2 18454179 1944644 We propose that Nox1 mediates oncogenic Ras induced upregulation of VEGF and angiogenesis by activating Sp1 through *dependent* phosphorylation of [Sp1] . Positive_regulation SP1 EPHB2 18852899 1977130 M-CSF also induced the nuclear localization of [Sp1] , which was *blocked* by inhibition . Positive_regulation SP1 EPHB2 19934343 2172259 [Sp-1] phosphorylation was *dependent* on sulindac sulfide induced activation . Positive_regulation SP1 EPHB2 20121399 2206948 In THP-1 cells , p38 , , and JNK inhibition *increased* NF-kappaB and [Sp1] binding to the IL-12p40 promoter , while inhibiting AP-1 binding . Positive_regulation SP1 EPHB2 20392694 2267275 *mediated* phosphorylation of [Sp1] was responsible for a decreased transcriptional activity of Sp1 in the kidney upon ischemia/reperfusion . Positive_regulation SP1 EPHB2 20506264 2307835 An inhibitor *suppressed* [Sp1] phosphorylation and bFGF reduced TSP50 expression at the mRNA level . Positive_regulation SP1 EPHB2 22326662 2576145 Activated by LPLI translocates from cytoplasm to nuclear and *leads* to increasing interaction with [Sp1] , triggering a progressive phosphorylation of Sp1 on Thr453 and Thr739 , resulting in the upregulation of VEGF expression . Positive_regulation SP1 IFI27 12773549 1095175 ( Kip1 ) *leads* to increased [Sp1] binding through a decrease in Sp1 protein turnover . Positive_regulation SP1 IL1B 12888570 1142864 Moreover , *increased* steady-state levels of [Sp1] and Sp3 mRNAs , whereas it enhanced Sp3 protein expression and inhibited Sp1 protein biosynthesis . Positive_regulation SP1 IL1B 18772363 1985857 Gelshift assays showed that *increased* [Sp1] but not p50 binding to cognate HKalpha probes and that Sp1 also interacts with an HKalpha NF-kappaB site when bound to its cognate HKalpha cis-response element . Positive_regulation SP1 MAP2K6 10751319 681511 The results revealed that [Sp1] kinase activity ( like gastrin promoter activation ) is inhibited by PD-98059 and , therefore , is *dependent* on 1 ( Mek 1 ) . Positive_regulation SP1 MAP2K6 11327698 807637 and ( iii ) the inhibition of activation by U0126 *reduces* [Sp1] phosphorylation , P4 activity and IGF-II mRNA in HBx transfected HepG2 cells . Positive_regulation SP1 MAP2K6 14597566 1187443 Helicobacter pylori stimulates host vascular endothelial growth factor-A ( vegf-A ) gene expression via dependent *activation* of [Sp1] and Sp3 . Positive_regulation SP1 NPNT 21316587 2388694 Moreover , we show that [Sp1 transcription factor] links ERK5 to Klf2/4 , and that , a Klf transcriptional target , is *involved* in muscle cell fusion . Positive_regulation SP1 TNF 12633744 1068264 Intracellular metal ion chelators inhibit induced [SP-1] *activation* and adhesion molecule expression in human aortic endothelial cells . Positive_regulation SP1 TNF 15175554 1254917 Electrophoresis mobility shift assay ( EMSA ) and Western blot analysis showed that both the nuclear factor-kappaB (NF-kappaB) and the [specificity protein-1 (SP-1)] were *activated* by . Positive_regulation SP1 TNF 15480988 1320324 significantly *enhanced* [Sp1/DNA] binding . Positive_regulation SP1 TNF 1618817 191369 *Induction* of low density lipoprotein receptor and a [transcription factor SP-1] by in human microvascular endothelial cells . Positive_regulation SP1 TNF 17307735 1719081 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of mediator , coactivator , and corepressor proteins and [Sp1 transcription factor] in *response* to all-trans-RA and . Positive_regulation SP1 TNF 17575006 1786109 *stimulated* binding of [Sp1] to the MUC1 promoter in intact cells was demonstrated by chromatin immunoprecipitation assay . Positive_regulation SP1 TNF 17626239 1798473 Thus , we provide the first evidence that ES and ES-cell derived vascular cells lack cytokine expression in *response* to stimulation due to low levels of c-fos and transcriptional activation of [Sp1] that can be regulated by inhibition of histone deacetylase activity . Positive_regulation SP1 TNF 18357389 1887723 The transactivation of *stimulated* NF-kappaB , AP-1 and [Sp-1] were inhibited by U0126 and SB203580 treatment . Positive_regulation SP1 TNF 7649977 319157 Importantly , *induced* the association between p53 and [Sp1] in Jurkat T cells . Positive_regulation SP1 TNFSF10 20150555 2227519 We conclude that TRAIL induction involves FGF-2 , [Sp1-phosphorylation] and NFkappaB and that *promotes* VSMC proliferation and neointima formation after arterial injury . Positive_regulation SP100 FOXA1 16214823 1464769 In vitro , *regulated* the activity of CCSP and SP-A , SP-B , [SP-C] , and SP-D promoters as assessed by luciferase reporter assays in HeLa , H441 , and MLE15 cells . Positive_regulation SP3 CAPN8 17316402 1699845 Glutamate receptor activation evokes *mediated* degradation of [Sp3] and Sp4 , the prominent Sp-family transcription factors in neurons . Positive_regulation SP3 EPHB2 14597566 1187445 Helicobacter pylori stimulates host vascular endothelial growth factor-A ( vegf-A ) gene expression via dependent *activation* of Sp1 and [Sp3] . Positive_regulation SP3 IL1B 12888570 1142865 Moreover , *increased* steady-state levels of Sp1 and [Sp3] mRNAs , whereas it enhanced Sp3 protein expression and inhibited Sp1 protein biosynthesis . Positive_regulation SP3 MAP2K6 14597566 1187451 Helicobacter pylori stimulates host vascular endothelial growth factor-A ( vegf-A ) gene expression via dependent *activation* of Sp1 and [Sp3] . Positive_regulation SP4 CAPN8 17316402 1699859 Glutamate receptor activation evokes *mediated* degradation of Sp3 and [Sp4] , the prominent Sp-family transcription factors in neurons . Positive_regulation SPAG11B IL1B 11297615 801645 Indeed , the proinflammatory cytokine *stimulated* expression of [EP2] and EP4 transcripts in concentration- and time dependent manner in the GL cells . Positive_regulation SPAG11B IL1B 11297615 801647 Our data suggest that *induces* expression of [EP2] and EP4 receptors in human GL cells , and that EP2 receptor is expressed in both human and murine luteal glands . Positive_regulation SPAG11B PTGER2 11399653 824293 We also observed that EP1 but not is expressed in M-1 cells and [EP2] levels are not *induced* by NS-398 . Positive_regulation SPAG11B RORC 24812667 2939862 In Th17 cells isolated from humans , repressed EP2 by directly silencing PTGER2 transcription , and knock down of RORC *restored* [EP2] expression in Th17 cells . Positive_regulation SPAG8 IFI27 22692684 2638672 Furthermore , siRNA mediated suppression in 3T3-L1 adipocytes *resulted* in a significant inhibition of [11ß-Hsd1] expression , whereas an adenoviral mediated overexpression of Ifi202b increased 11ß-Hsd1 mRNA levels . Positive_regulation SPAG8 TNF 22294469 2617508 Gene reporter , RACE , and chemical inhibitor studies demonstrated that the *increase* in [11ß-HSD1] expression with (IL-1ß) occurred via the proximal HSD11B1 gene promoter and depended on NF-?B signaling . Positive_regulation SPARC EPHB2 24253315 2898103 In addition , miR-29b is upregulated following ERK inhibition , suggesting a Snail dependent pathway by which Snail activation of TGF-ß and signaling *results* in downregulation of miR-29b and subsequent upregulation of [SPARC] . Positive_regulation SPESP1 CA12 1759579 174521 The results suggest that is *involved* in the generation of [ESP] . Positive_regulation SPHK1 AKT1 17388800 1720862 The IGF-I effect on [SphK] activity was *blocked* by specific inhibitors of IGF-IR , and ERK1/2 phosphorylation . Positive_regulation SPHK1 AKT1 23732709 2796889 Acid ceramidase induces [sphingosine kinase 1/S1P] receptor 2-mediated *activation* of oncogenic signaling . Positive_regulation SPHK1 AKT2 17388800 1720863 The IGF-I effect on [SphK] activity was *blocked* by specific inhibitors of IGF-IR , and ERK1/2 phosphorylation . Positive_regulation SPHK1 AKT2 23732709 2796890 Acid ceramidase induces [sphingosine kinase 1/S1P] receptor 2-mediated *activation* of oncogenic signaling . Positive_regulation SPHK1 AKT3 17388800 1720864 The IGF-I effect on [SphK] activity was *blocked* by specific inhibitors of IGF-IR , and ERK1/2 phosphorylation . Positive_regulation SPHK1 AKT3 23732709 2796891 Acid ceramidase induces [sphingosine kinase 1/S1P] receptor 2-mediated *activation* of oncogenic signaling . Positive_regulation SPHK1 APOB 16516816 1530818 Oxidized immune complexes *induce* release of [sphingosine kinase] in human U937 monocytic cells . Positive_regulation SPHK1 ASAH1 23732709 2796892 *induces* [sphingosine kinase 1/S1P] receptor 2-mediated activation of oncogenic Akt signaling . Positive_regulation SPHK1 BCL2 15637591 1362800 Importantly , overexpression of the prosurvival protein Bcl-2 in A-375 cells markedly stimulated SphK1 expression and activity , while downregulation of *reduced* [SphK1] expression . Positive_regulation SPHK1 BTRC 20153728 2227604 In addition to inhibiting the well established Ras-ERK cascade , adenovirus mediated Spred2 over-expression inhibits constitutive and *stimulated* [sphingosine kinase-1 (SPHK1)] and Mcl-1 expression , as well as inhibiting proliferation and inducing apoptosis in CML cells . Positive_regulation SPHK1 C5 15302883 1303295 We demonstrate that rapidly *stimulates* [SPHK] activity in neutrophils and differentiated HL-60 cells . Positive_regulation SPHK1 CA2 11392623 823071 On the basis of these studies we propose , that following initial IP3 production by receptor mediated PLC activation , a local discrete increase in [ ] i *induces* [sphingosine kinase] stimulation , which ultimately leads to full calcium mobilization . Positive_regulation SPHK1 CA2 12531188 1048852 *dependent* translocation of [sphingosine kinase] : role in plasma membrane relocation but not activation . Positive_regulation SPHK1 CALM1 23223309 2708051 , the calcium and integrin binding protein ortholog , colocalizes with SPHK-1 at release sites and *regulates* muscarinic mediated synaptic [SPHK-1] recruitment . Positive_regulation SPHK1 CALM3 12531188 1048853 *dependent* translocation of [sphingosine kinase] : role in plasma membrane relocation but not activation . Positive_regulation SPHK1 CALM3 12531188 1048860 These data suggest a *role* for Ca ( 2+ ) in controlling the subcellular distribution but not the activity of [SPHK1a] . Positive_regulation SPHK1 CIB1 19854831 2187507 Translocation of [sphingosine kinase 1] to the plasma membrane is *mediated* by 1 . Positive_regulation SPHK1 CSF2 17490544 1739378 It is concluded that the [SphK] activity of monocytes collected from peripheral blood progenitor cell donors can be *activated* by . Positive_regulation SPHK1 CTNND2 15193146 1281015 ( neural plakophilin related armadillo repeat protein ) interacts with and *activates* [sphingosine kinase 1] . Positive_regulation SPHK1 CTNND2 15193146 1281016 In a purified system *stimulated* [SPHK1] in a dose dependent manner . Positive_regulation SPHK1 CUL1 20153728 2227605 In addition to inhibiting the well established Ras-ERK cascade , adenovirus mediated Spred2 over-expression inhibits constitutive and *stimulated* [sphingosine kinase-1 (SPHK1)] and Mcl-1 expression , as well as inhibiting proliferation and inducing apoptosis in CML cells . Positive_regulation SPHK1 DNAJB9 20008963 2217576 In addition , *upregulates* [sphingosine kinase 1] and sphingosine-1-phosphate (S1P) receptor 1 expression . Positive_regulation SPHK1 EDN1 16956968 1673370 , via ET ( A ) receptors coupled to pertussis toxin-insensitive G proteins , *stimulated* [SphK1] activity and induced its translocation to the membranes . Positive_regulation SPHK1 EGF 15993704 1429700 also *activates* [sphingosine kinase-1 (SPHK-1)] , which converts sphingosine to sphingosine-1-phosphate , and its inhibition with dimethyl sphingosine ( DMS ) increased trophoblast death . Positive_regulation SPHK1 EGF 15993704 1429716 Inhibition of SPHK-1 also did not affect EGF stimulated phosphorylation of PI-3 kinase , Akt , ERK1/2 or p38 but inhibition of PI-3 kinase with a specific inhibitor LY294002 partly ( 40 % ) inhibited the *stimulated* increase in [SPHK-1] activity . Positive_regulation SPHK1 EGF 16414307 1494926 The *stimulates* [sphingosine kinase-1] expression and activity in the human mammary carcinoma cell line MCF7 . Positive_regulation SPHK1 EGF 17855624 1858284 *induced* rapid phosphorylation of c-Src and PKCdelta and concomitant translocation of PKCdelta as well as [SphK1] to the plasma membrane . Positive_regulation SPHK1 EGF 17855624 1858288 Down-regulation of PKCdelta abolished *induced* [SphK1] translocation and up-regulation of PAI-1 by EGF ; Positive_regulation SPHK1 EGF 17855624 1858292 Similarly , inhibition of c-Src activity by PP2 blocked both *induced* translocation of [SphK1] and PKCdelta to the plasma membrane and up-regulation of PAI-1 expression . Positive_regulation SPHK1 EGF 9099730 422812 Platelet derived growth factor ( PDGF ) and serum , but not , *stimulated* [sphingosine kinase] activity in Swiss 3T3 fibroblasts and increased intracellular concentrations of sphingosine 1-phosphate (SPP) , a sphingolipid second messenger ( Olivera , A. , and Spiegel , S. ( 1993 ) Nature 365 , 557-560 ) . Positive_regulation SPHK1 EGF 9395290 468324 In contrast , and insulin-like growth factor-1 , which stimulate proliferation of PC12 cells , induced only small and transient *increases* in [sphingosine kinase] activity . Positive_regulation SPHK1 EPHB2 18723875 1955944 Inhibition of PKC and *reduced* [SphK1/2] activity . Positive_regulation SPHK1 EPHB2 19932089 2198064 Dihydrotestosterone ( DHT ) triggered cell growth in steroid deprived MC3T3 cells , which was associated with a rapid stimulation of [SphK1] and *activation* of both Akt and signaling pathways . Positive_regulation SPHK1 EPHB2 23545258 2777736 Given the up-regulated expression of [SphK1] in *response* to the silence of N-ras and other interactions between and SphK1 , it was speculated that combined inhibition of Ras/ERK and SphK1 would create enhanced antitumor effects . Positive_regulation SPHK1 ERBB2 20516217 2284155 We demonstrate here a new concept termed `` oncogene tolerance '' whereby *increases* [sphingosine kinase 1 (SK1)] expression in estrogen receptor positive ( ER ( + ) ) MCF-7 HER2 cells and SK1 , in turn , limits HER2 expression in a negative-feedback manner . Positive_regulation SPHK1 ERVK-6 23658376 2810834 FXa stimulated transcription of [SPHK1] was *mediated* by the and PAR-2 . Positive_regulation SPHK1 F10 23658376 2810829 induced mitogenesis and migration *require* [sphingosine kinase] activity and S1P formation in human vascular smooth muscle cells . Positive_regulation SPHK1 F10 23658376 2810832 The aim of the study was to investigate whether the activated ( FXa ) *regulates* [SPHK1] transcription and the formation of S1P and subsequent mitogenesis and migration of human vascular smooth muscle cells (SMC) . Positive_regulation SPHK1 F2R 15626732 1387914 Here , we show that APC enhanced endothelial barrier integrity in a dual-chamber system dependent on binding to endothelial protein C receptor , *activation* of , and activity of cellular [sphingosine kinase] . Positive_regulation SPHK1 F2RL1 23658376 2810835 FXa stimulated transcription of [SPHK1] was *mediated* by the protease activated receptor-1 (PAR-1) and . Positive_regulation SPHK1 FGF1 9395290 468334 [Sphingosine kinase] activity *induced* by NGF , but not , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 FGF10 9395290 468335 [Sphingosine kinase] activity *induced* by NGF , but not , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 FGF11 9395290 468336 [Sphingosine kinase] activity *induced* by NGF , but not , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 FGF12 9395290 468337 [Sphingosine kinase] activity *induced* by NGF , but not , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 FGF13 9395290 468338 [Sphingosine kinase] activity *induced* by NGF , but not , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 FGF14 9395290 468339 [Sphingosine kinase] activity *induced* by NGF , but not , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 FGF16 9395290 468340 [Sphingosine kinase] activity *induced* by NGF , but not , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 FGF17 9395290 468341 [Sphingosine kinase] activity *induced* by NGF , but not , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 FGF18 9395290 468342 [Sphingosine kinase] activity *induced* by NGF , but not , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 FGF19 9395290 468343 [Sphingosine kinase] activity *induced* by NGF , but not , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 FGF2 12204793 983414 The role of [sphingosine kinase (SphK)] on *induced* proliferation of cerebral , aortic and coronary smooth muscle cells (SMC) was addressed using D-erythro-N , N-dimethylsphingosine ( DMS ) , an inhibitor of SphK which blocks conversion of sphingosine to sphingosine-1-phosphate (S1P) . Positive_regulation SPHK1 FGF2 9395290 468344 [Sphingosine kinase] activity *induced* by NGF , but not , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 FGF20 9395290 468345 [Sphingosine kinase] activity *induced* by NGF , but not , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 FGF21 9395290 468346 [Sphingosine kinase] activity *induced* by NGF , but not , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 FGF22 9395290 468347 [Sphingosine kinase] activity *induced* by NGF , but not , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 FGF23 9395290 468348 [Sphingosine kinase] activity *induced* by NGF , but not , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 FGF3 9395290 468349 [Sphingosine kinase] activity *induced* by NGF , but not , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 FGF4 9395290 468350 [Sphingosine kinase] activity *induced* by NGF , but not , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 FGF5 9395290 468351 [Sphingosine kinase] activity *induced* by NGF , but not , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 FGF6 9395290 468352 [Sphingosine kinase] activity *induced* by NGF , but not , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 FGF7 9395290 468353 [Sphingosine kinase] activity *induced* by NGF , but not , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 FGF8 9395290 468354 [Sphingosine kinase] activity *induced* by NGF , but not , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 FGF9 9395290 468355 [Sphingosine kinase] activity *induced* by NGF , but not , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 FN1 11936187 894670 We suggest that might *activate* [sphingosine kinase] , and that the sphingosine 1-phosphate thereby generated induces a calcium signal via a G-protein dependent mechanism . Positive_regulation SPHK1 FYN 16316995 1511365 Normal activation of [SphK1] and -2 was *restored* by expression of wild type but only partly with a kinase-defective Fyn , indicating that induction of SphK1 and SphK2 depended on both catalytic and noncatalytic properties of Fyn . Positive_regulation SPHK1 FYN 18377769 1888585 and Lyn also *activate* [sphingosine kinases (SphK)] , which generate sphingosine-1-phosphate (S1P) , thus contributing to mast cell chemotaxis and degranulation . Positive_regulation SPHK1 GDNF 17555548 1778566 Furthermore , we demonstrated that ERK1/2 and PI3 kinase are involved in *induced* [SPHK1] transcription by using specific inhibitors . Positive_regulation SPHK1 GDNF 19357361 2120031 and DHA *enhanced* [SphK] expression in photoreceptors , while inhibiting S1P synthesis blocked GDNF mitogenic effects and DHA effects on differentiation . Positive_regulation SPHK1 GDNF 21769916 2494716 We previously reported *induced* [SPHK1] gene expression in a neuroblastoma cell line , TGW ( Murakami et al. [ 2007 ] J Neurochem 102 : 1585-1594 ) . Positive_regulation SPHK1 GDNF 21769916 2494717 In the present study , we focused on the regulatory mechanism of GAP43 ( GDNF induced neuronal phenotype ) transcription to further elucidate physiological roles of *induced* [SPHK1] expression and activity . Positive_regulation SPHK1 GDNF 21769916 2494972 Taken together , our results showed that in TGW cells , *increased* [SPHK1] transcription , leading to the production and secretion of S1P . Positive_regulation SPHK1 HRAS 23545258 2777737 Given the up-regulated expression of [SphK1] in *response* to the silence of N-ras and other interactions between and SphK1 , it was speculated that combined inhibition of Ras/ERK and SphK1 would create enhanced antitumor effects . Positive_regulation SPHK1 IGF1 17388800 1720860 *activated* [SphK] , leading to sphingosine-1-phosphate (S1P) formation . Positive_regulation SPHK1 IGF1 17388800 1720865 The IGF-I effect on [SphK] activity was *blocked* by specific inhibitors of , PI3K/Akt and ERK1/2 phosphorylation . Positive_regulation SPHK1 IGF1 17388800 1720880 The disruption of signaling *prevented* the IGFBP-3 effect on tube formation , [SphK] activity and VEGF release . Positive_regulation SPHK1 IGF1 17388800 1720887 Thus , IGFBP-3 positively regulates angiogenesis through involvement of signaling and subsequent [SphK/S1P] *activation* . Positive_regulation SPHK1 IGF1 9395290 468325 In contrast , epidermal growth factor and , which stimulate proliferation of PC12 cells , induced only small and transient *increases* in [sphingosine kinase] activity . Positive_regulation SPHK1 IGF2 17388800 1720866 The IGF-I effect on [SphK] activity was *blocked* by specific inhibitors of , PI3K/Akt and ERK1/2 phosphorylation . Positive_regulation SPHK1 IGF2 17388800 1720888 Thus , IGFBP-3 positively regulates angiogenesis through involvement of signaling and subsequent [SphK/S1P] *activation* . Positive_regulation SPHK1 IGFBP3 15247143 1289569 alone *activated* [sphingosine kinase (SK)] and increased SK1 mRNA ; Positive_regulation SPHK1 IGFBP3 19633297 2132100 [SphK1] expression and activity were *stimulated* by approximately 2-fold over 24 h. Silencing of sphingosine 1-phosphate receptor 1 ( S1P1 ) or S1P3 , but not S1P2 , abolished the effect of IGFBP-3 on EGF stimulated EGFR activation . Positive_regulation SPHK1 IL10 19074142 2030439 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL11 19074142 2030440 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL13 19074142 2030441 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL15 19074142 2030442 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL16 19074142 2030443 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL18 18602364 1941492 As a result , inhibition of SPHK by SKI blocked phosphorylation of p38 MAPK , showing that [SPHK] *activation* by is an upstream signal of p38 MAPK activation . Positive_regulation SPHK1 IL18 19074142 2030444 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL19 19074142 2030445 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL1A 18819934 1970429 Although *enhanced* the expression of [sphingosine kinase 1 (SphK1)] , the enzyme that produces S1P , down-regulation of SphK1 had no effect on the IL-1 induced uPAR or PAI-1 mRNA expression , suggesting that these actions of IL-1 are independent of S1P production . Positive_regulation SPHK1 IL1A 19074142 2030484 The *induced* [SphK1] up-regulation can be blocked by the inhibition of JNK , the overexpression of the dominant negative c-Jun ( TAM67 ) , and the down-regulation of c-Jun expression by small interference RNA . Positive_regulation SPHK1 IL1A 19074142 2030485 *Activation* of [SphK1] expression by occurs on the level of transcription and is mediated via a novel AP-1 element located within the first intron of the sphk1 gene . Positive_regulation SPHK1 IL1A 19074142 2030487 In summary , our results suggest that [SphK1] expression is transcriptionally *regulated* by in glioblastoma cells , and this pathway may be important in regulating survival and invasiveness of glioblastoma cells . Positive_regulation SPHK1 IL1A 24464131 2913148 In *response* to , cIAP2 and the sphingosine kinase [SphK1] ( the enzyme that generates S1P ) formed a complex with IRF1 , which led to its activation . Positive_regulation SPHK1 IL1B 15855330 1400107 or TNF-alpha *increased* islet [SPHK] activity within 15 min to 1 h ; Positive_regulation SPHK1 IL1B 15855330 1400111 Compared with basal values , and TNF-alpha induced *increases* in [SPHK1a] mRNA levels relative to 18S ribosomal RNA in INS-1 cells within 1 h ; Positive_regulation SPHK1 IL1B 15855330 1400116 , but not TNF-alpha , *induced* relative [SPHK1a] mRNA expression levels within 1 h in islets , whereas SPHK2 mRNA levels were unchanged . Positive_regulation SPHK1 IL1B 15855330 1400122 Thus , and TNF-alpha induced an early and sustained *increase* in [SPHK] activity in INS-1 cells and isolated islets , suggesting that S1P plays a role in the pathological response of pancreatic beta-cells to cytokines . Positive_regulation SPHK1 IL1B 16038795 1437473 Using human A549 epithelial lung carcinoma cells as a model system , we observed transient upregulation of [sphingosine kinase type 1 (SPHK1)] enzyme activity upon *stimulation* with both TNF-alpha or . Positive_regulation SPHK1 IL1B 17512943 1751188 Both hypoxia and alone and in combination *enhanced* fibroblast [SphK] activity . Positive_regulation SPHK1 IL1B 18703638 1974312 Inhibition of [sphingosine kinase] to block S1P production did not affect IL-1beta induced COX-2 expression , but S1P amplified *induced* p38 activation and COX-2 expression . Positive_regulation SPHK1 IL2 19074142 2030446 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL20 19074142 2030447 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL21 19074142 2030448 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL22 19074142 2030431 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL24 19074142 2030429 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL25 19074142 2030430 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL26 19074142 2030435 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL27 19074142 2030436 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL3 19074142 2030449 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL31 19074142 2030437 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL32 19074142 2030434 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL33 19074142 2030433 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL34 19074142 2030438 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL37 19074142 2030432 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL4 19074142 2030450 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL5 19074142 2030451 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL6 17686057 1781484 Activation of [sphingosine kinase] *mediates* suppressive effect of on human multiple myeloma cell apoptosis . Positive_regulation SPHK1 IL6 17686057 1781492 This study found that *activated* [SPHK] in MM cells , which mediates the suppressive effects of IL-6 on MM cell apoptosis . Positive_regulation SPHK1 IL6 17686057 1781494 Specific inhibitors of the phosphatidylinositol-3 kinase and extracellular signal regulated kinase/mitogen activated protein kinase pathways blocked the *induced* activation of [SPHK] . Positive_regulation SPHK1 IL6 17686057 1781496 It was further demonstrated that induced *activation* of [SPHK] inhibited dexamethasone induced apoptosis of MM cells . Positive_regulation SPHK1 IL6 17686057 1781505 stimulation or retroviral mediated overexpression of SPHK1 in MM cells *resulted* in increased intracellular [SPHK] activity and upregulation of myeloid cell leukaemia-1 (Mcl-1) , leading to increased cell proliferation and survival . Positive_regulation SPHK1 IL6 19074142 2030452 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL7 19074142 2030453 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL8 19074142 2030454 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 IL9 19074142 2030455 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Positive_regulation SPHK1 JUN 24342046 2905331 *regulates* [sphingosine kinase 1] expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose . Positive_regulation SPHK1 JUN 24342046 2905333 Given the binding motifs for AP-1 within the first intron of the SphK1 gene , we speculated that the activated in the kidney under HG condition possibly *regulates* [SphK1] expression in a positive feedback manner , thereby promoting the sustained activation of SphK1-S1P pathway and mediating the pathological progression of DN . Positive_regulation SPHK1 KRAS 23545258 2777738 Given the up-regulated expression of [SphK1] in *response* to the silence of N-ras and other interactions between and SphK1 , it was speculated that combined inhibition of Ras/ERK and SphK1 would create enhanced antitumor effects . Positive_regulation SPHK1 LPA 18701480 1950417 also *up-regulated* [SphK1] expression in other human cancer cells that endogenously express the LPA ( 1 ) receptor , such as DLD1 colon cancer cells and MDA-MB-231 breast cancer cells , but not in HT29 colon cancer cells or MDA-MB-453 breast cancer cells , which do not express the LPA ( 1 ) receptor . Positive_regulation SPHK1 LPA 18701480 1950420 LPA transactivated the epidermal growth factor receptor (EGFR) in these cells , and the EGFR inhibitor AG1478 attenuated the increased [SphK1] and S1P(3) expression *induced* by . Positive_regulation SPHK1 LPA 20804754 2324577 Although LPA activates numerous signaling pathways downstream of its receptors , including extracellular-signal regulated kinase 1/2 , p38 , JNK , and Akt , and the transactivation of the epidermal growth factor receptor , pharmacological and molecular approaches demonstrated that only activation of ERK1 , in addition to the CCAAT/enhancer binding protein ß transcription factor , is involved in transcriptional *upregulation* of [SphK1] by . Positive_regulation SPHK1 LYN 18377769 1888586 Fyn and also *activate* [sphingosine kinases (SphK)] , which generate sphingosine-1-phosphate (S1P) , thus contributing to mast cell chemotaxis and degranulation . Positive_regulation SPHK1 MAPK3 17388800 1720867 The IGF-I effect on [SphK] activity was *blocked* by specific inhibitors of IGF-IR , PI3K/Akt and phosphorylation . Positive_regulation SPHK1 MAPK3 17555548 1778567 Furthermore , we demonstrated that and PI3 kinase are *involved* in GDNF induced [SPHK1] transcription by using specific inhibitors . Positive_regulation SPHK1 MAPK3 20804754 2324575 Lysophosphatidic acid stimulates gastric cancer cell proliferation via *dependent* upregulation of [sphingosine kinase 1] transcription . Positive_regulation SPHK1 MAPK3 20804754 2324578 Although LPA activates numerous signaling pathways downstream of its receptors , including extracellular-signal regulated kinase 1/2 , p38 , JNK , and Akt , and the transactivation of the epidermal growth factor receptor , pharmacological and molecular approaches demonstrated that only activation of , in addition to the CCAAT/enhancer binding protein ß transcription factor , is *involved* in transcriptional upregulation of [SphK1] by LPA . Positive_regulation SPHK1 MAPK3 21803151 2484742 [SphK1] activation *requires* PKC and MAPK . Positive_regulation SPHK1 MBTPS1 14592418 1159930 The antiapoptotic effect of *required* activation of [sphingosine kinase] and was accompanied by an increase in MAP-kinase phosphorylation . Positive_regulation SPHK1 MBTPS1 20007411 2210575 In contrast , induction of prostaglandin endoperoxide synthase 2 by and *stimulation* of [SPHK1] by estradiol and cytokines suggests a role for S1P in the termination of pregnancy . Positive_regulation SPHK1 MBTPS1 21660960 2442631 Interestingly , exogenously added *induced* significant up-regulation of [sphingosine kinase-1] and the synthesis of additional S1P , and expression of S1PR1 ,3 , but not S1PR2 . Positive_regulation SPHK1 MBTPS1 22960176 2678725 Interestingly , exogenously added *induced* up-regulation of [SphK1] and the synthesis of additional S1P , suggesting a self amplifying loop of S1P to enhance macrophage migration . Positive_regulation SPHK1 MYB 23328083 2758325 c-MYB overexpression and siRNA for c-Myb affected SPHK1 expression , confirming the important regulatory *role* of in [SPHK1] expression . Positive_regulation SPHK1 NGF 11238741 791126 , which protects PC12 cells from serum withdrawal induced apoptosis , also *stimulated* [SPHK1] activity . Positive_regulation SPHK1 NGF 16135093 1474850 Transcription factor specificity protein 1 (Sp1) is the main regulator of *induced* [sphingosine kinase 1] gene expression of the rat pheochromocytoma cell line , PC12 . Positive_regulation SPHK1 NGF 16135093 1474851 induced an *increase* in [SPHK] enzyme activity and protein about double those in PC12 cells , and NGF induced SPHK1 mRNA was three times higher than in the control . Positive_regulation SPHK1 NGF 16135093 1474855 The minimal 5 ' promoter was determined , and TrkA specific inhibitor K252a inhibited the *induced* promoter activity of [SPHK1] . Positive_regulation SPHK1 NGF 16135093 1474856 These results suggest the signal transduction pathway from NGF receptor TrkA to transcription factor Sp1 protein binding to the promoter Sp1-like motif in *induced* rat [SPHK1] gene expression . Positive_regulation SPHK1 NGF 9395290 468332 Of the growth factors examined , was the most potent *activator* of [sphingosine kinase] , inducing a 4-fold increase in Vmax . Positive_regulation SPHK1 NGF 9395290 468356 [Sphingosine kinase] activity *induced* by , but not FGF , was blocked by the protein kinase inhibitor K252a when added simultaneously , with minimal effect when added after 60 min . Positive_regulation SPHK1 NRAS 23545258 2777739 Given the up-regulated expression of [SphK1] in *response* to the silence of N-ras and other interactions between and SphK1 , it was speculated that combined inhibition of Ras/ERK and SphK1 would create enhanced antitumor effects . Positive_regulation SPHK1 NTF3 16313513 1486951 Immunocytochemistry and confocal microscopy indicated that *induces* translocation of [SphK1] from the cytoplasm to the plasma membrane of oligodendrocytes , a process accompanied by increased SphK1 activity in the membrane fraction where its substrate sphingosine resides . Positive_regulation SPHK1 NTF3 9278531 451381 Nerve growth factor (NGF) , a for pheochromocytoma PC12 cells , *induced* a biphasic increase in the activity of [sphingosine kinase] , the enzyme that catalyzes the formation of SPP . Positive_regulation SPHK1 PCSK5 18385762 1944170 , a hydrophobic compound chemically named N- ( 1,3-dihydroxyisopropyl ) -2-hexyl-3-oxo-decanamide , *activated* [SphK] ( obtained from C57BL/6 murine blood and F9-12 cell lysates ) in a dose dependent manner . Positive_regulation SPHK1 PDGFB 17341687 1760097 In keeping with these findings , *up-regulated* S1P2 and [SphK1] mRNAs , increased SphK activity , and S1P2 induced PDGF-BB mRNA . Positive_regulation SPHK1 PIK3CA 11418646 830245 Pretreatment of cells with N , N-dimethylsphingosine ( DMS ) , an *inhibitor* of [SphK] , or LY 294002 , an inhibitor of that acts upstream of Akt , increased the number of apoptotic cells induced by TNF-alpha in Ad5IkappaB infected Huh-7 and Hc cells . Positive_regulation SPHK1 PIK3CA 17388800 1720868 The IGF-I effect on [SphK] activity was *blocked* by specific inhibitors of IGF-IR , and ERK1/2 phosphorylation . Positive_regulation SPHK1 PIK3R1 11418646 830246 Pretreatment of cells with N , N-dimethylsphingosine ( DMS ) , an *inhibitor* of [SphK] , or LY 294002 , an inhibitor of that acts upstream of Akt , increased the number of apoptotic cells induced by TNF-alpha in Ad5IkappaB infected Huh-7 and Hc cells . Positive_regulation SPHK1 PIK3R1 17388800 1720869 The IGF-I effect on [SphK] activity was *blocked* by specific inhibitors of IGF-IR , and ERK1/2 phosphorylation . Positive_regulation SPHK1 PLAT 15231724 1289418 The *induced* [sphingosine kinase-1] activation was mediated by Src , since it was inhibited by herbimycin A and in SrcK- cells ( overexpressing a dominant negative kinase defective form of Src ) and by ERK1/2 ( early phase peaking at 15 min ) . Positive_regulation SPHK1 PLD1 11856736 936786 Here we also show that [SPHK1] activity depends on phospholipase D1 and that FcepsilonRI triggered mast cell degranulation *depends* primarily on the activation of both and SPHK1 . Positive_regulation SPHK1 PRL 17639048 1771042 *upregulates* [sphingosine kinase-1] expression and activity in the human breast cancer cell line MCF7 and triggers enhanced proliferation and migration . Positive_regulation SPHK1 PSAP 11156962 780678 We report that treatment *induced* extracellular signal regulated kinases ( ERKs ) and [sphingosine kinase] activity , increased DNA synthesis , and prevented cell apoptosis . Positive_regulation SPHK1 PTGS2 18723875 1955946 This effect was blocked by SphK inhibitors , providing evidence of the close relationship between [SphK] activity and *induction* in rat myometrium . Positive_regulation SPHK1 RBPJ 21302306 2480172 The expression of a dominant negative ( dn ) form of in 3T3 cells *induces* transcription of FGF1 and [sphingosine kinase 1 (SphK1)] , which is a component of FGF1 export pathway . Positive_regulation SPHK1 SKP1 20153728 2227603 In addition to inhibiting the well established Ras-ERK cascade , adenovirus mediated Spred2 over-expression inhibits constitutive and *stimulated* [sphingosine kinase-1 (SPHK1)] and Mcl-1 expression , as well as inhibiting proliferation and inducing apoptosis in CML cells . Positive_regulation SPHK1 SPHK1 17686057 1781504 IL-6 stimulation or retroviral mediated overexpression of in MM cells *resulted* in increased intracellular [SPHK] activity and upregulation of myeloid cell leukaemia-1 (Mcl-1) , leading to increased cell proliferation and survival . Positive_regulation SPHK1 SPHK2 15855330 1400115 IL-1beta , but not TNF-alpha , *induced* relative [SPHK1a] mRNA expression levels within 1 h in islets , whereas mRNA levels were unchanged . Positive_regulation SPHK1 SRC 15231724 1289417 The tPA induced [sphingosine kinase-1] activation was *mediated* by , since it was inhibited by herbimycin A and in SrcK- cells ( overexpressing a dominant negative kinase defective form of Src ) and by ERK1/2 ( early phase peaking at 15 min ) . Positive_regulation SPHK1 SRC 17855624 1858291 Similarly , inhibition of activity by PP2 *blocked* both EGF induced translocation of [SphK1] and PKCdelta to the plasma membrane and up-regulation of PAI-1 expression . Positive_regulation SPHK1 SRC 18574469 1966023 oncogene product *increases* [sphingosine kinase 1] expression through mRNA stabilization : alteration of AU-rich element binding proteins . Positive_regulation SPHK1 SRC 18574469 1966026 Our results showed , for the first time , a novel mechanism of *induced* [SPHK1] overexpression . Positive_regulation SPHK1 TFPT 17879749 1797117 In the liver , *increased* the expression of [sphingosine kinase] and inhibited the expression of sphingosine 1-phosphate lyase . Positive_regulation SPHK1 TGFB1 15485866 1347356 [Sphingosine kinase 1 (SPHK1)] is *induced* by and mediates TIMP-1 up-regulation . Positive_regulation SPHK1 TGFB2 15485866 1347357 [Sphingosine kinase 1 (SPHK1)] is *induced* by and mediates TIMP-1 up-regulation . Positive_regulation SPHK1 TGFB3 15485866 1347358 [Sphingosine kinase 1 (SPHK1)] is *induced* by and mediates TIMP-1 up-regulation . Positive_regulation SPHK1 TLR1 23878196 2835397 Additionally , IL-10 , TGF-ß1 , peroxisome proliferator activated receptor ? , LIGHT ( TNF superfamily 14 ) , and [sphingosine kinase-1] were up-regulated , and such M2 polarization was *dependent* on ligation . Positive_regulation SPHK1 TLR10 23878196 2835405 Additionally , IL-10 , TGF-ß1 , peroxisome proliferator activated receptor ? , LIGHT ( TNF superfamily 14 ) , and [sphingosine kinase-1] were up-regulated , and such M2 polarization was *dependent* on ligation . Positive_regulation SPHK1 TLR2 23878196 2835398 Additionally , IL-10 , TGF-ß1 , peroxisome proliferator activated receptor ? , LIGHT ( TNF superfamily 14 ) , and [sphingosine kinase-1] were up-regulated , and such M2 polarization was *dependent* on ligation . Positive_regulation SPHK1 TLR3 23878196 2835399 Additionally , IL-10 , TGF-ß1 , peroxisome proliferator activated receptor ? , LIGHT ( TNF superfamily 14 ) , and [sphingosine kinase-1] were up-regulated , and such M2 polarization was *dependent* on ligation . Positive_regulation SPHK1 TLR4 20661259 2388859 mediated [SphK1] *activation* was found to be critical for the redox dependent activation of HIF-1a and ASK1 , as well as for the prevention of LPS induced activation of caspase 3 and the expression of pro-inflammatory cytokine interleukin-6 . Positive_regulation SPHK1 TLR4 23878196 2835400 Additionally , IL-10 , TGF-ß1 , peroxisome proliferator activated receptor ? , LIGHT ( TNF superfamily 14 ) , and [sphingosine kinase-1] were up-regulated , and such M2 polarization was *dependent* on ligation . Positive_regulation SPHK1 TLR5 23878196 2835401 Additionally , IL-10 , TGF-ß1 , peroxisome proliferator activated receptor ? , LIGHT ( TNF superfamily 14 ) , and [sphingosine kinase-1] were up-regulated , and such M2 polarization was *dependent* on ligation . Positive_regulation SPHK1 TLR6 23878196 2835406 Additionally , IL-10 , TGF-ß1 , peroxisome proliferator activated receptor ? , LIGHT ( TNF superfamily 14 ) , and [sphingosine kinase-1] were up-regulated , and such M2 polarization was *dependent* on ligation . Positive_regulation SPHK1 TLR7 23878196 2835402 Additionally , IL-10 , TGF-ß1 , peroxisome proliferator activated receptor ? , LIGHT ( TNF superfamily 14 ) , and [sphingosine kinase-1] were up-regulated , and such M2 polarization was *dependent* on ligation . Positive_regulation SPHK1 TLR8 23878196 2835403 Additionally , IL-10 , TGF-ß1 , peroxisome proliferator activated receptor ? , LIGHT ( TNF superfamily 14 ) , and [sphingosine kinase-1] were up-regulated , and such M2 polarization was *dependent* on ligation . Positive_regulation SPHK1 TLR9 23878196 2835404 Additionally , IL-10 , TGF-ß1 , peroxisome proliferator activated receptor ? , LIGHT ( TNF superfamily 14 ) , and [sphingosine kinase-1] were up-regulated , and such M2 polarization was *dependent* on ligation . Positive_regulation SPHK1 TNF 10551885 565410 We now show that HDL profoundly inhibit *stimulated* [sphingosine kinase] activity in endothelial cells resulting in a decrease in sphingosine 1-phosphate production and adhesion protein expression . Positive_regulation SPHK1 TNF 10567432 567724 *Activation* of [sphingosine kinase] by inhibits apoptosis in human endothelial cells . Positive_regulation SPHK1 TNF 10567432 567728 The induced [SphK] *activation* is independent of sphingomyelinase and ceramidase activities , suggesting that TNF affects this enzyme directly other than through a mass effect on sphingomyelin degradation . Positive_regulation SPHK1 TNF 10567432 567730 Thus , we demonstrate that the *activation* of [SphK] by is an important signaling for protection from the apoptotic effect of TNF in endothelial cells . Positive_regulation SPHK1 TNF 15855330 1400106 IL-1beta or *increased* islet [SPHK] activity within 15 min to 1 h ; Positive_regulation SPHK1 TNF 15855330 1400110 Compared with basal values , IL-1beta and induced *increases* in [SPHK1a] mRNA levels relative to 18S ribosomal RNA in INS-1 cells within 1 h ; Positive_regulation SPHK1 TNF 15855330 1400114 IL-1beta , but not , *induced* relative [SPHK1a] mRNA expression levels within 1 h in islets , whereas SPHK2 mRNA levels were unchanged . Positive_regulation SPHK1 TNF 15855330 1400121 Thus , IL-1beta and induced an early and sustained *increase* in [SPHK] activity in INS-1 cells and isolated islets , suggesting that S1P plays a role in the pathological response of pancreatic beta-cells to cytokines . Positive_regulation SPHK1 TNF 16038795 1437472 Using human A549 epithelial lung carcinoma cells as a model system , we observed transient upregulation of [sphingosine kinase type 1 (SPHK1)] enzyme activity upon *stimulation* with both or IL-1beta . Positive_regulation SPHK1 TNF 16354764 1519362 Further study demonstrated that *induced* [sphingosine kinase] activity was inhibited by glabridin , and the inhibitory effect of glabridin on TNF-alpha induced ICAM-1 expression was reversed by addition of exogenous S1P . Positive_regulation SPHK1 TNF 16575915 1550166 We show that rapidly *triggers* S1P generation and activation of [SPHK] . Positive_regulation SPHK1 TNF 17114809 1677162 has been shown to *activate* [sphingosine kinase (SphK)] in a variety of cell types . Positive_regulation SPHK1 TNF 17114809 1677164 Signaling mechanisms through which [SphK] *mediated* the effect of on DNA synthesis were then examined . Positive_regulation SPHK1 TRAF2 11777919 916478 In addition , by using a kinase inactive dominant negative SphK and a mutant SphK that lacks TRAF2 binding motif we show that the interaction of with SphK and subsequent *activation* of [SphK] are critical for prevention of apoptosis during TNF stimulation . Positive_regulation SPHK2 F2R 15626732 1387915 Here , we show that APC enhanced endothelial barrier integrity in a dual-chamber system dependent on binding to endothelial protein C receptor , *activation* of , and activity of cellular [sphingosine kinase] . Positive_regulation SPHK2 IL1B 15855330 1400109 or TNF-alpha *increased* islet [SPHK] activity within 15 min to 1 h ; Positive_regulation SPHK2 IL1B 15855330 1400126 Thus , and TNF-alpha induced an early and sustained *increase* in [SPHK] activity in INS-1 cells and isolated islets , suggesting that S1P plays a role in the pathological response of pancreatic beta-cells to cytokines . Positive_regulation SPHK2 IL1B 17512943 1751189 Both hypoxia and alone and in combination *enhanced* fibroblast [SphK] activity . Positive_regulation SPHK2 IL1B 18703638 1974313 Inhibition of [sphingosine kinase] to block S1P production did not affect IL-1beta induced COX-2 expression , but S1P amplified *induced* p38 activation and COX-2 expression . Positive_regulation SPHK2 SPHK1 17686057 1781506 IL-6 stimulation or retroviral mediated overexpression of in MM cells *resulted* in increased intracellular [SPHK] activity and upregulation of myeloid cell leukaemia-1 (Mcl-1) , leading to increased cell proliferation and survival . Positive_regulation SPHK2 TNF 10551885 565411 We now show that HDL profoundly inhibit *stimulated* [sphingosine kinase] activity in endothelial cells resulting in a decrease in sphingosine 1-phosphate production and adhesion protein expression . Positive_regulation SPHK2 TNF 10567432 567727 *Activation* of [sphingosine kinase] by inhibits apoptosis in human endothelial cells . Positive_regulation SPHK2 TNF 10567432 567729 The *induced* [SphK] activation is independent of sphingomyelinase and ceramidase activities , suggesting that TNF affects this enzyme directly other than through a mass effect on sphingomyelin degradation . Positive_regulation SPHK2 TNF 10567432 567733 Thus , we demonstrate that the *activation* of [SphK] by is an important signaling for protection from the apoptotic effect of TNF in endothelial cells . Positive_regulation SPHK2 TNF 15855330 1400108 IL-1beta or *increased* islet [SPHK] activity within 15 min to 1 h ; Positive_regulation SPHK2 TNF 15855330 1400125 Thus , IL-1beta and induced an early and sustained *increase* in [SPHK] activity in INS-1 cells and isolated islets , suggesting that S1P plays a role in the pathological response of pancreatic beta-cells to cytokines . Positive_regulation SPHK2 TNF 16354764 1519363 Further study demonstrated that *induced* [sphingosine kinase] activity was inhibited by glabridin , and the inhibitory effect of glabridin on TNF-alpha induced ICAM-1 expression was reversed by addition of exogenous S1P . Positive_regulation SPHK2 TNF 16575915 1550170 We show that rapidly *triggers* S1P generation and activation of [SPHK] . Positive_regulation SPHK2 TNF 17114809 1677163 has been shown to *activate* [sphingosine kinase (SphK)] in a variety of cell types . Positive_regulation SPHK2 TNF 17114809 1677165 Signaling mechanisms through which [SphK] *mediated* the effect of on DNA synthesis were then examined . Positive_regulation SPI1 IL1B 11823535 909324 EMSAs using THP-1 cell nuclear extracts indicated that significantly *induced* [Spi-1] binding to its target site within the IL1B promoter that was maximal at 1 h after stimulation , correlating with the kinetics of IL-1beta induction . Positive_regulation SPI1 IL1B 11823535 909326 We conclude that the IL1B promoter is an IL-1beta-responsive sequence as a result of its ability to bind [Spi-1] in *response* to . Positive_regulation SPN FAS 16953114 1610957 Further , [CD43] signaling of Jurkat cells *induced* oligomerization on the cell surfaces implying that CD43 ligation have effects on early stage of Fas induced T cell death . Positive_regulation SPN TNF 8350952 227185 In contrast to these data , interferon-gamma , , retinoic acid and 1,25 ( OH ) 2-vitamin D3 *induced* the up-regulation of [leukosialin] in a promyelocytic leukemia cell line HL-60 . Positive_regulation SPN TNF 9638335 513955 Although did not *induce* significant modification of [CD43] expression on suspended cells , we showed that 40 % of membrane CD43 is released during neutrophil TNF induced adhesion to serum coated plates or endothelial cells , and that migration through the endothelial monolayer did not result in further shedding . Positive_regulation SPON2 NFKB1 20205276 2223011 [Mindin] expression is upregulated during intestinal inflammation and may *induce* promoter activation in a TLR-9 mediated manner . Positive_regulation SPON2 NM 16105980 1482162 Furthermore , neutrophils directly bind to immobilized mindin , and [mindin] matrix *mediates* in vitro . Positive_regulation SPON2 RELA 20205276 2223012 [Mindin] expression is upregulated during intestinal inflammation and may *induce* promoter activation in a TLR-9 mediated manner . Positive_regulation SPP1 ABCG2 23935934 2826764 Furthermore , host [OPN] *induces* VEGF , and ERK1/2 expression and activation in B16-WT cells . Positive_regulation SPP1 EPHB2 16440309 1554567 The inhibitor ( PD98059 ) *blocked* Elk-1 phosphorylation , as well as COL1 and [OPN] gene expression . Positive_regulation SPP1 EPHB2 16778192 1573199 Inhibition of phosphorylation in NIH/oncVav1 cells *led* to a decrease in [osteopontin] expression , implying that the elevated osteopontin expression in these cells is dependent on ERK phosphorylation . Positive_regulation SPP1 EPHB2 19798549 2195755 Further , inhibitor *inhibited* significantly [OPN] expression , Elk1 phosphorylation , and activator protein-1 (AP-1)-DNA binding activation , but not FAK phosphorylation , in the force applied cells . Positive_regulation SPP1 EPHB2 22588951 2700781 Aldosterone induced [osteopontin] expression in vascular smooth muscle cells *involves* MR , , and p38 MAPK . Positive_regulation SPP1 EPHB2 24530412 2924260 It is noteworthy that a tyrosine kinase receptor inhibitor , K252a , an inhibitor ( U0126 ) , and a PI3Kinase-Akt inhibitor ( LY294002 ) remarkably *attenuated* TrkB , ERK , and Akt phosphorylation as well as increase of [OPN] mRNA expression in the HCEM cells , respectively . Positive_regulation SPP1 HBEGF 10432399 633903 in both cortex and OSOM rapidly *increased* their [OPN] expression , with a maximum at 24 hours after reperfusion followed by a slow decrease . Positive_regulation SPP1 IL1B 12096844 961150 In primary culture of Cbfa1-/- chondrocytes , transforming growth factor (TGF) beta1 , platelet derived growth factor ( PDGF ) , , and thyroid hormone ( T3 ) *induced* [osteopontin] and MMP-13 expression . Positive_regulation SPP1 IL1B 14755545 1205622 ERK1/2 and JNKs , but not p38 kinase , are involved in reactive oxygen species mediated *induction* of [osteopontin] gene expression by angiotensin II and in adult rat cardiac fibroblasts . Positive_regulation SPP1 IL1B 16211580 1507907 *induces* [osteopontin] expression in pulmonary fibroblasts . Positive_regulation SPP1 IL1B 16211580 1507913 Our results demonstrate a potent and dramatic increase in [osteopontin] expression *induced* by , whereas tumor necrosis factor-alpha , transforming growth factor-beta , and angiotensin II had minimal effect . Positive_regulation SPP1 IL1B 16211580 1507919 Stimulation with *resulted* in the secretion of soluble [osteopontin] protein . Positive_regulation SPP1 IL1B 17110428 1686040 [OPN] promoter activity was increased in the *presence* of , IL-1beta induced NO , and an inducer of NO synthesis . Positive_regulation SPP1 IL1B 19076536 2024209 On the contrary , [OPN] *induced* IFN-gamma , IL-4 , IL-5 , IL-13 , , and TNF-alpha production in sinonasal mucosa . Positive_regulation SPP1 IL1B 7499354 332926 In vitro , and interferon-gamma *increased* [osteopontin] mRNA levels in CMEC as well as NOS2 expression in both CMEC and cardiac myocytes . Positive_regulation SPP1 MAP2K6 12009309 940970 Additionally , inhibition of activity , which activates MAPK , *attenuated* TPA induced [OPN] expression . Positive_regulation SPP1 MAP2K6 24530412 2924269 It is noteworthy that a tyrosine kinase receptor inhibitor , K252a , an inhibitor ( U0126 ) , and a PI3Kinase-Akt inhibitor ( LY294002 ) remarkably *attenuated* TrkB , ERK , and Akt phosphorylation as well as increase of [OPN] mRNA expression in the HCEM cells , respectively . Positive_regulation SPP1 MUC16 17389136 1716019 Progesterone down regulation of its receptors in luminal and glandular epithelia correlates temporally with a reduction in anti-adhesive land *induction* of secreted galectin 15 ( LGALSI5 ) and [secreted phosphoprotein 1] , which are proposed to regulate trophectoderm proliferation and adhesion . Positive_regulation SPP1 NT5E 18980528 1983316 We examined how *regulates* the mRNA expression of bone/cementum related proteins ( alkaline phosphatase [ ALPase ] , [osteopontin] [ OPN ] , osteocalcin [ OC ] , and bone morphogenetic protein [ BMP]-2 ) in cultures of HPL cells . Positive_regulation SPP1 PLAU 11804183 892573 We have recently shown that either exogenous or endogenous , transfected [OPN] *induces* both expression and increased invasiveness of 21 PT ( non-tumorigenic ) and 21 NT ( tumorigenic ) human mammary epithelial cells . Positive_regulation SPP1 PLAU 12771144 1113350 To our knowledge , this is first report that [OPN] *induces* NFkappaB activity and secretion by activating PI 3'-kinase/Akt/IKK mediated signaling pathways and further demonstrates a functional molecular link between OPN induced PI 3'-kinase dependent Akt phosphorylation and NFkappaB mediated uPA secretion , and all of these ultimately control the motility of breast cancer cells . Positive_regulation SPP1 PLAU 14704150 1219031 [Osteopontin] *induces* AP-1 mediated secretion of through c-Src dependent epidermal growth factor receptor transactivation in breast cancer cells . Positive_regulation SPP1 PLAU 16012053 1431624 Taken together , [OPN] *induces* NFkappaB activity and secretion by activating PI 3'-kinase/Akt/IKK mediated signaling pathways and further demonstrates a functional molecular link between OPN induced PI 3'-kinase dependent Akt phosphorylation and NFkappaB mediated uPA secretion , and all of these ultimately control the motility and invasiveness of breast cancer cells . Positive_regulation SPP1 SPHK1 10545499 564553 Expression of markedly *increased* [SPP] levels in NIH 3T3 fibroblasts and HEK293 cells , but no detectable secretion of SPP into the medium was observed . Positive_regulation SPP1 SPHK1 10802064 691674 Similar to mSPHK1a , when HEK293 cells were transfected with hSPHK1 , there were marked increases in activity resulting in elevated [SPP] *levels* . Positive_regulation SPP1 SPHK1 9581819 503684 In contrast , activity increased more slowly and reached maximal levels only after 20 h of exposure , *leading* to a concomitant increase in [SPP] level . Positive_regulation SPP1 TGM2 17189522 1709327 [Osteopontin] *upregulation* and polymerization by in calcified arteries of Matrix Gla protein-deficient mice . Positive_regulation SPP1 TGM2 9880554 584022 Circular dichroism analysis of monomeric and polymeric osteopontin indicated that treatment *induces* a conformational change in [osteopontin] , probably exposing motives relevant to its interactions with other extracellular molecules . Positive_regulation SPP1 TNF 11815603 922504 Surprisingly , we found that , although C6 cells can secrete [SPP] , which is *enhanced* by , treatment of C6 cells with exogenous SPP or dihydro-SPP had no affect on BH ( 4 ) biosynthesis . Positive_regulation SPP1 TNF 16211580 1507912 Our results demonstrate a potent and dramatic increase in [osteopontin] expression *induced* by interleukin-1beta (IL-1beta) , whereas , transforming growth factor-beta , and angiotensin II had minimal effect . Positive_regulation SPP1 TNF 19076536 2024207 On the contrary , [OPN] *induced* IFN-gamma , IL-4 , IL-5 , IL-13 , IL-1beta , and production in sinonasal mucosa . Positive_regulation SPP1 TNF 20056194 2201026 Fibronectin supports *induced* [osteopontin] expression through beta1 integrin and ERK in HN-22 cells . Positive_regulation SPP1 TNF 20056194 2201027 The data showed that significantly *increased* [OPN] expression only in the FN-coated condition . Positive_regulation SPP1 TNF 20056194 2201030 Our results indicate that FN coordinates mediated [OPN] *induction* via beta1 integrin dependent signaling mechanism that activates ERK . Positive_regulation SPP1 TNF 22684781 2633455 Moreover , [OPN] and MMP-9 were *enhanced* by and down-regulated by anti-TNF-a treatment in healthy PBMC . Positive_regulation SPP1 TNF 7785911 309925 Since [OPN] can be *induced* in macrophages by stimulation and since on the other hand osteopontin appears to decrease the level of nitric oxide synthase , and thus the production of nitric oxide , osteopontin might also indirectly have an antifibrotic effect . Positive_regulation SPP1 TNF 9610617 508778 To investigate whether MCP-1 , CINC , RANTES , [osteopontin] and ICAM-1 mRNA could be *induced* in cultured rat mesangial cells by interleukin-1beta(IL-1beta) , and lipopolysaccharide (LPS) , and whether MCP-1 and CINC gene expression could be modulated by dexamethasone , Northern blot assays were performed . Positive_regulation SPP1 TNF 9610617 508788 On the other hand , IL-1beta , and LPS *had* little effect on [osteopontin] gene expression but fetal calf serum could increase osteopontin mRNA . Positive_regulation SPP2 SPHK1 10545499 564555 Expression of markedly *increased* [SPP] levels in NIH 3T3 fibroblasts and HEK293 cells , but no detectable secretion of SPP into the medium was observed . Positive_regulation SPP2 SPHK1 10802064 691676 Similar to mSPHK1a , when HEK293 cells were transfected with hSPHK1 , there were marked increases in activity resulting in elevated [SPP] *levels* . Positive_regulation SPP2 SPHK1 9581819 503686 In contrast , activity increased more slowly and reached maximal levels only after 20 h of exposure , *leading* to a concomitant increase in [SPP] level . Positive_regulation SPP2 TNF 11815603 922505 Surprisingly , we found that , although C6 cells can secrete [SPP] , which is *enhanced* by , treatment of C6 cells with exogenous SPP or dihydro-SPP had no affect on BH ( 4 ) biosynthesis . Positive_regulation SPRR1B ELF3 12682075 1093259 Although synergistically *activated* c-Jun- and PMA enhanced [SPRR1B] transcription , coexpression of Sp1 and ESE-1 showed no synergistic or additive effect on promoter activity , indicating an obligatory role for AP-1 proteins in such regulation . Positive_regulation SPRR1B GCDH 19365590 2058692 Compared to Aire-sufficient controls , conjunctival decreased and corneal [SPRR1B] *increased* in Aire-deficient mice with significant differences noted at both 8 and 16 weeks . Positive_regulation SPRR1B IFNG 18172072 1855833 IL1alpha , IL1beta , IL6 , , and TNFalpha *induced* [SPRR1B] expression in vitro and the local expression of IL1beta and IFNgamma was elevated in ocular tissues of patients with SS and aire-deficient mice . Positive_regulation SPRR1B IFNG 20042643 2248046 Here the molecular mechanisms controlling [SPRR1B] gene expression in *response* to IL-1beta and are elucidated . Positive_regulation SPRR1B IL1B 18172072 1855834 IL1alpha , , IL6 , IFNgamma , and TNFalpha *induced* [SPRR1B] expression in vitro and the local expression of IL1beta and IFNgamma was elevated in ocular tissues of patients with SS and aire-deficient mice . Positive_regulation SPRR1B IL1B 20042643 2248047 Here the molecular mechanisms controlling [SPRR1B] gene expression in *response* to and IFN-gamma are elucidated . Positive_regulation SPRR1B JUN 12091247 960053 We have recently shown that phorbol 13-myristate 12-acetate ( PMA ) -stimulated [SPRR1B] transcription in Clara-like H441 cells is mainly *mediated* by and c-Jun N-terminal kinase-1 ( JNK1 ) . Positive_regulation SPRR1B MAP2K1 10918063 736988 However , *mediated* induction of [SPRR1B] probably does not depend on extracellular signal regulated kinases 1 and 2 , suggesting the requirement of another kinase ( s ) . Positive_regulation SPRR1B MAP2K1 12091247 960056 Though mitogen activated protein kinase (MAPK) kinase ( pathway inhibitors strongly *suppressed* both basal and PMA-inducible [SPRR1B] transcription , overexpression of dominant negative ( dn ) forms of extracellular signal regulated kinase ( ERK ) -1 and/or -2 did not have any significant effect indicating the involvement of another ERK-like MAPK in this pathway . Positive_regulation SPRR1B MAP2K2 12091247 960057 Though mitogen activated protein kinase (MAPK) kinase ( pathway inhibitors strongly *suppressed* both basal and PMA-inducible [SPRR1B] transcription , overexpression of dominant negative ( dn ) forms of extracellular signal regulated kinase ( ERK ) -1 and/or -2 did not have any significant effect indicating the involvement of another ERK-like MAPK in this pathway . Positive_regulation SPRR1B MAPK1 12091247 960058 Though kinase ( MEK)-1/2 pathway inhibitors strongly *suppressed* both basal and PMA-inducible [SPRR1B] transcription , overexpression of dominant negative ( dn ) forms of extracellular signal regulated kinase ( ERK ) -1 and/or -2 did not have any significant effect indicating the involvement of another ERK-like MAPK in this pathway . Positive_regulation SPRR1B MAPK10 12091247 960059 Though kinase ( MEK)-1/2 pathway inhibitors strongly *suppressed* both basal and PMA-inducible [SPRR1B] transcription , overexpression of dominant negative ( dn ) forms of extracellular signal regulated kinase ( ERK ) -1 and/or -2 did not have any significant effect indicating the involvement of another ERK-like MAPK in this pathway . Positive_regulation SPRR1B MAPK11 12091247 960060 Though kinase ( MEK)-1/2 pathway inhibitors strongly *suppressed* both basal and PMA-inducible [SPRR1B] transcription , overexpression of dominant negative ( dn ) forms of extracellular signal regulated kinase ( ERK ) -1 and/or -2 did not have any significant effect indicating the involvement of another ERK-like MAPK in this pathway . Positive_regulation SPRR1B MAPK12 12091247 960061 Though kinase ( MEK)-1/2 pathway inhibitors strongly *suppressed* both basal and PMA-inducible [SPRR1B] transcription , overexpression of dominant negative ( dn ) forms of extracellular signal regulated kinase ( ERK ) -1 and/or -2 did not have any significant effect indicating the involvement of another ERK-like MAPK in this pathway . Positive_regulation SPRR1B MAPK13 12091247 960062 Though kinase ( MEK)-1/2 pathway inhibitors strongly *suppressed* both basal and PMA-inducible [SPRR1B] transcription , overexpression of dominant negative ( dn ) forms of extracellular signal regulated kinase ( ERK ) -1 and/or -2 did not have any significant effect indicating the involvement of another ERK-like MAPK in this pathway . Positive_regulation SPRR1B MAPK14 12091247 960063 Though kinase ( MEK)-1/2 pathway inhibitors strongly *suppressed* both basal and PMA-inducible [SPRR1B] transcription , overexpression of dominant negative ( dn ) forms of extracellular signal regulated kinase ( ERK ) -1 and/or -2 did not have any significant effect indicating the involvement of another ERK-like MAPK in this pathway . Positive_regulation SPRR1B MAPK15 12091247 960055 Though kinase ( MEK)-1/2 pathway inhibitors strongly *suppressed* both basal and PMA-inducible [SPRR1B] transcription , overexpression of dominant negative ( dn ) forms of extracellular signal regulated kinase ( ERK ) -1 and/or -2 did not have any significant effect indicating the involvement of another ERK-like MAPK in this pathway . Positive_regulation SPRR1B MAPK3 12091247 960064 Though kinase ( MEK)-1/2 pathway inhibitors strongly *suppressed* both basal and PMA-inducible [SPRR1B] transcription , overexpression of dominant negative ( dn ) forms of extracellular signal regulated kinase ( ERK ) -1 and/or -2 did not have any significant effect indicating the involvement of another ERK-like MAPK in this pathway . Positive_regulation SPRR1B MAPK4 12091247 960065 Though kinase ( MEK)-1/2 pathway inhibitors strongly *suppressed* both basal and PMA-inducible [SPRR1B] transcription , overexpression of dominant negative ( dn ) forms of extracellular signal regulated kinase ( ERK ) -1 and/or -2 did not have any significant effect indicating the involvement of another ERK-like MAPK in this pathway . Positive_regulation SPRR1B MAPK6 12091247 960066 Though kinase ( MEK)-1/2 pathway inhibitors strongly *suppressed* both basal and PMA-inducible [SPRR1B] transcription , overexpression of dominant negative ( dn ) forms of extracellular signal regulated kinase ( ERK ) -1 and/or -2 did not have any significant effect indicating the involvement of another ERK-like MAPK in this pathway . Positive_regulation SPRR1B MAPK7 12091247 960051 ( ERK5 ) *regulates* squamous differentiation marker [SPRR1B] transcription in Clara-like H441 cells . Positive_regulation SPRR1B MAPK7 12091247 960067 Though kinase ( MEK)-1/2 pathway inhibitors strongly *suppressed* both basal and PMA-inducible [SPRR1B] transcription , overexpression of dominant negative ( dn ) forms of extracellular signal regulated kinase ( ERK ) -1 and/or -2 did not have any significant effect indicating the involvement of another ERK-like MAPK in this pathway . Positive_regulation SPRR1B MAPK7 12091247 960071 Overexpression of strongly *suppressed* both basal and PMA-inducible [SPRR1B] transcription , whereas wild-type ERK5 upregulated it . Positive_regulation SPRR1B MAPK8 12091247 960054 We have recently shown that phorbol 13-myristate 12-acetate ( PMA ) -stimulated [SPRR1B] transcription in Clara-like H441 cells is mainly *mediated* by activator protein-1 (AP-1) and ( JNK1 ) . Positive_regulation SPRR1B MAPK8 12091247 960068 Though kinase ( MEK)-1/2 pathway inhibitors strongly *suppressed* both basal and PMA-inducible [SPRR1B] transcription , overexpression of dominant negative ( dn ) forms of extracellular signal regulated kinase ( ERK ) -1 and/or -2 did not have any significant effect indicating the involvement of another ERK-like MAPK in this pathway . Positive_regulation SPRR1B MAPK9 12091247 960069 Though kinase ( MEK)-1/2 pathway inhibitors strongly *suppressed* both basal and PMA-inducible [SPRR1B] transcription , overexpression of dominant negative ( dn ) forms of extracellular signal regulated kinase ( ERK ) -1 and/or -2 did not have any significant effect indicating the involvement of another ERK-like MAPK in this pathway . Positive_regulation SPRR1B TNF 18172072 1855832 IL1alpha , IL1beta , IL6 , IFNgamma , and *induced* [SPRR1B] expression in vitro and the local expression of IL1beta and IFNgamma was elevated in ocular tissues of patients with SS and aire-deficient mice . Positive_regulation SPRR3 IL13 15731505 1396369 Transgenic overexpression of in the lungs *resulted* in a marked increase of [SPRR2] expression , and allergen induced SPRR2 expression was significantly decreased in IL-13-deficient mice . Positive_regulation SPRR3 IL6 15558059 1361151 In conclusion , BEC signaling noncoordinately *upregulates* BEC [SPRR2] that appears to contribute to modification of the biliary barrier under conditions of stress . Positive_regulation SPRR3 IVL 16639001 1552958 In HCECs , [SPRR2] and involucrin proteins were detected in the cytosolic fraction , and levels *increased* after UVB . Positive_regulation SPRR3 LRPPRC 15558059 1361150 In conclusion , BEC signaling noncoordinately *upregulates* BEC [SPRR2] that appears to contribute to modification of the biliary barrier under conditions of stress . Positive_regulation SPRR3 STAT3 15558059 1361149 In conclusion , BEC signaling noncoordinately *upregulates* BEC [SPRR2] that appears to contribute to modification of the biliary barrier under conditions of stress . Positive_regulation SPRR3 STAT6 15814686 1393073 Thus , IL-4 induces genes in addition to IL-12 that suppress *mediated* [SPRR] gene induction . Positive_regulation SPRY4 EPHB2 14977631 1250869 The expression of [Sprouty4 (Spry4)] , an intracellular FGF receptor antagonist , shows a temporally and spatially restricted pattern in embryonic lung and is *induced* by signaling . Positive_regulation SPRY4 WNT7A 20501643 2276547 We showed that the activity of the [Spry4] promoter is *increased* by signaling through peroxisome proliferator activated receptor gamma . Positive_regulation SPTAN1 CAPN8 12108543 963158 Activation of *results* in the breakdown of [alpha II spectrin] ( alpha-fodrin ) , a neuronal cytoskeleton protein , which has previously been detected in various in vitro and in vivo neuronal injury models . Positive_regulation SQSTM1 EPHB2 25128814 2957244 can *regulate* cellular levels of LC3B and [SQSTM1/p62] at expression levels . Positive_regulation SQSTM1 IL1B 14622206 1168652 Stimulation of IL-1 receptor by may *induce* the phosphorylation of tyrosine residues in many effector proteins through the activation of [p60c-src] kinase . Positive_regulation SQSTM1 MAP2K6 25128814 2957250 can *regulate* cellular levels of LC3B and [SQSTM1/p62] at expression levels . Positive_regulation SQSTM1 TNF 9125146 424164 Activation of cellular signaling pathways either by epidermal growth factor , lipopolysaccharide or did not *enhance* the level of the [A170] protein . Positive_regulation SRC ADRB2 11278940 802948 Agonist triggers tyrosine phosphorylation of the and recruitment and *activation* of [Src] . Positive_regulation SRC ADRB2 12221082 998308 We propose that the *activates* [Src] via two independent mechanisms to mediate distinct signaling pathways , one through Galpha ( s ) to Rap1 and ERKs and the other through Gbetagamma to Ras and AKT . Positive_regulation SRC ANGPT1 16949254 1682502 PP2 inhibited both *induced* capillary morphogenesis and [Src] activation in HUVECs cultured under normoxic conditions , but the PP2 activity was significantly impaired in HUVECs cultured under hypoxic conditions . Positive_regulation SRC CAPN8 12379276 997158 [Src] and epidermal growth factor receptor (EGFR) stimulated cell motility is *dependent* upon activation . Positive_regulation SRC CEACAM6 15047698 1244103 cross linking *increased* [c-Src] activation and induced tyrosine phosphorylation of p125(FAK) focal adhesion kinase . Positive_regulation SRC CEACAM6 18614350 1947295 Suppression of expression using small interfering RNA ( siRNA ) completely reversed migration and invasion of MCF-7 : 5C and MCF-7 : 2A cells and it significantly *reduced* phosphorylated Akt and [c-Src] expression in these cells . Positive_regulation SRC CTGF 20432467 2282448 In this study we demonstrate that TGF-beta1 activates Src kinase in ROS17/2.8 cells and that treatment with the Src family kinase inhibitor PP2 prevents [Src] activation and *induction* by TGF-beta1 . Positive_regulation SRC CTGF 21760921 2456297 Recombinant *activated* [Src] and Erk1/2 signaling , and induced phosphorylation of Fli1 , but was unable to stimulate Smad1 or Smad3 phosphorylation . Positive_regulation SRC EDN2 9857056 555342 , a well known hypertrophic agonist , *increased* activity of [c-Src] , c-Yes , and Fyn within minutes and promoted a selective redistribution of each of these kinases within the cell . Positive_regulation SRC EPHB2 11100733 755931 The G betagamma-responsive activation induced by H2O2 is independent of ligands binding to Gi-coupled receptors , but *requires* phosphatidylinositol-3-kinase and [Src] activation . Positive_regulation SRC EPHB2 11751158 898194 Together these results indicate that M ( 2 ) receptors are coupled to [Src] tyrosine kinase and subsequent *activation* of in cultured CSMC . Positive_regulation SRC EPHB2 12060808 952823 The potentiation by PBN of the and [Src] kinase *activation* by H2O2 required extracellular Ca2+ and appeared dependent on voltage sensitive Ca2+ channels . Positive_regulation SRC EPHB2 15381832 1298780 The gastric mucosal phospholipid secretory responses to isoproterenol , furthermore , were inhibited by PP2 , a selective *inhibitor* of tyrosine kinase [Src] responsible for ligand independent EGFR phosphorylation , but not by inhibitor , PD98059 . Positive_regulation SRC EPHB2 15919658 1433646 VEGF induced activation was not dependent on phosphoinositide (PI) 3-kinase activation but *required* sequential phosphorylation of type 2 VEGF receptor , PLCgamma and [c-Src] , as demonstrated by inhibitors SU1498 , U73122 , and PP1 , respectively . Positive_regulation SRC EPHB2 15985706 1429021 The gastric mucin secretory responses to isoproterenol , furthermore , were inhibited by PP2 , a selective *inhibitor* of tyrosine kinase [Src] responsible for ligand independent EGFR autophosphorylation , but not by inhibitor , PD98059 . Positive_regulation SRC EPHB2 16511561 1535614 Metalloproteinase/Presenilin1 processing of ephrinB regulates *induced* [Src] phosphorylation and signaling . Positive_regulation SRC EPHB2 16511561 1535634 The mechanism , however , by which *activates* [Src] in the ephrinB expressing cells is unknown . Positive_regulation SRC EPHB2 16597733 1544911 This protection occurs independently of neurophin signaling but requires [Src] *activation* of ( extracellular signal regulated kinase ) and Akt . Positive_regulation SRC EPHB2 17088251 1675905 We investigated whether [Src] and Rac1 mediate deformation *induced* FAK and phosphorylation and proliferation in human Caco-2 and rat IEC-6 intestinal epithelial cells . Positive_regulation SRC EPHB2 18448311 1908331 Surprisingly , even in the absence of EGF addition , [c-Src] expression *induced* activation of EGFR and of EGFR mediated downstream signaling targets and Shc . Positive_regulation SRC EPHB2 18622047 1936328 Our findings demonstrate that leptin protection of gastric mucosa against ethanol cytotoxicity involves [Src] kinase *mediated* bifurcated activation of and Akt that leads to up-regulation of the respective prostaglandin and nitric oxide synthase pathways . Positive_regulation SRC EPHB2 19602257 2112091 [Src] *induces* up-regulation of activity and its target transcription factors , CREB and ERalpha , through attenuation of PP2A activity . Positive_regulation SRC EPHB2 19778233 2141042 The induction of TNF-alpha and TGF-beta1 by silica was suppressed by [Src] *inhibitor* ( PP1 ) , inhibitor ( PD98059 ) , but not by p38 kinase inhibitor ( SB203580 ) . Positive_regulation SRC F2R 15383630 1299010 Finally , activation *induces* [Src] phosphorylation , which is reversed by using the Src tyrosine kinase inhibitor PP2 , suggesting that Src activation plays a permissive role for PAR1 mediated ERK1/2 activation and cell proliferation probably acting downstream of the EGFR . Positive_regulation SRC F2R 19245830 2050742 In this process , the *induced* [c-Src] plays a critical role through two routes ; Positive_regulation SRC FAS 18471522 1910392 In quiescent HSCs , *led* to a rapid phosphorylation of the epidermal growth factor receptor (EGFR) , extracellular signal regulated kinase ( Erk ) , and [c-Src] , but not of c-Jun-N-terminal kinase and p47(phox) , an activating subunit of reduced nicotinamide adenine dinucleotide phosphate oxidase . Positive_regulation SRC FOXO1 18786922 1980674 Blockade of Akt activation by LY294002 , FoxO1 translocation by constitutively nuclear mutant , or [c-Src] *activation* by the chemical inhibitor PP2 , respectively , blunted SDF-1 suppression of gluconeogenesis . Positive_regulation SRC IL1B 16477040 1554873 We show here that *mediated* activation of the protein tyrosine kinase [Src] depended on a MyD88 interaction with the IL-1RI/IL-1RAcP complex . Positive_regulation SRC IL1B 16771830 1599265 *induces* a MyD88 dependent and ceramide mediated activation of [Src] in anterior hypothalamic neurons . Positive_regulation SRC IL1B 17299794 1718838 [Src] , PDGFR , and PI3K/Akt *mediated* the effects of because pretreatment with PP1 , AG1296 , and wortmannin also abrogated IL-1beta stimulated Src , PDGFR , and Akt phosphorylation , respectively . Positive_regulation SRC IL1B 18315570 1897509 *stimulated* [c-Src] , PDGFR , and Akt phosphorylation and proMMP-9 expression were attenuated by the inhibitors of c-Src ( PP1 ) , PDGFR ( AG1296 ) , and PI3K ( LY294002 ) , respectively , or transfection with dominant negative plasmid of c-Src or short hairpin RNAs of PDGFR and Akt . Positive_regulation SRC IL1B 19878566 2160818 We report that VEGF and IL-1beta-stimulate endothelial permeability via Src dependent pathway by increasing the Src phosphorylation and Ag-NP block the VEGF-and *induced* [Src] phosphorylation at Y419 . Positive_regulation SRC ITGA9 19470583 2091143 The cytoplasmic domain of integrin alpha9 was crucial for *induced* [Src] activation , subsequent signaling events and cell migration . Positive_regulation SRC MAP2K6 9234720 445414 Although neither constitutively activated ( MEK-2E ) nor v-Src was sufficient individually to differentiate the H19-7 cells , coexpression of constitutively activated MEK and [v-Src] *induced* neurite outgrowth . Positive_regulation SRC MMP28 21505267 2448599 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the [Src] and activating transcription factor 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or . Positive_regulation SRC MMP7 21505267 2448615 We found that aldosterone can induce the expression of Nox1 , which is upregulated by the activation of the [Src] and activating transcription factor 1 ( ATF1 ) , but can not be *suppressed* by the inhibitors of the epidermal growth factor receptor (EGFR) or . Positive_regulation SRC PDZK1 18174467 1869948 Alternatively , is *required* for HDL/SR-BI to induce [Src] phosphorylation . Positive_regulation SRC S100B 21209080 2391855 The *dependent* activation of diaphanous-1/Rac1/JNK/AP-1 , Ras/Rac1/NF-?B and [Src/Ras/PI3K/RhoA/diaphanous-1] results in the up-regulation of expression of the chemokines , CCL3 , CCL5 , and CXCL12 , whose release and activity are required for S100B to stimulate microglia migration . Positive_regulation SRC SLC38A3 12488346 1032999 We found a significant increase in [pp60(c-Src)] kinase activity in *response* to both and PG ( 0.1-1.0 nM ) , suggesting that growth effects of both the precursor and fully processed gastrin molecules may be mediated via similar pathways . Positive_regulation SRC TLR7 15491991 1347417 *Induction* of SOCS-3 and cytokine-inducible [Src] homology 2-containing protein ( CIS ) by stimulation was strictly dependent on MyD88 but showed differing needs in case of SOCS-1 . Positive_regulation SRC TMEM100 9188717 437355 The tyrosine phosphatase CD45 functions to *activate* [Src-family] member kinase activity in T lymphocytes . Positive_regulation SRC TMEM156 9188717 437373 The tyrosine phosphatase CD45 functions to *activate* [Src-family] member kinase activity in T lymphocytes . Positive_regulation SRC TMEM211 9188717 437453 The tyrosine phosphatase CD45 functions to *activate* [Src-family] member kinase activity in T lymphocytes . Positive_regulation SRC TMEM213 9188717 437390 The tyrosine phosphatase CD45 functions to *activate* [Src-family] member kinase activity in T lymphocytes . Positive_regulation SRC TNF 11832448 910228 *increased* peroxide production , leading to [Src] protein expression as well as Src activity in src transfectants . Positive_regulation SRC TNF 11832448 910229 *Activation* of [Src] by led to reduced E-cadherin levels and enhanced invasion of src transfectants . Positive_regulation SRC TNF 12645577 1069704 Furthermore , the dominant negative [c-Src] ( KM ) mutant inhibited *induction* of ICAM-1 promoter activity by or TPA . Positive_regulation SRC TNF 12645577 1069710 These data suggest that , in addition to activating NIK , also *activates* PKC dependent [c-Src] . Positive_regulation SRC TNF 12707358 1082860 These data suggest that , in addition to activating NIK , also *activates* PKC dependent [c-Src] . Positive_regulation SRC TNF 12947019 1151612 Shear stress significantly inhibited SHP-2 phosphatase activity without affecting induced [Src] family kinase *activation* . Positive_regulation SRC TNF 16275891 1502464 Many neutrophil responses to *require* beta2-integrin dependent signaling and subsequent [Src] family kinase activation . Positive_regulation SRC TNF 19760502 2264279 ErbB-2 phosphorylation at Tyr877 residue was mediated by *induced* [c-Src] activation . Positive_regulation SRC TNF 20333651 2266136 On the other hand , *stimulated* the phosphorylation of [c-Src] , EGFR , Akt , JNK1/2 , and c-Jun , which were inhibited by pretreatment with Gö6983 . Positive_regulation SRC TNF 20657842 2293429 Mechanistically , *activated* [Src family kinase (SFK)] only in Thy-1- MEFs . Positive_regulation SRC TNF 21474822 2428165 The goal of this study was to determine whether *induced* [Src] activation and intercellular adhesion molecule-1 ( ICAM-1 ) phosphorylation rapidly increase endothelial cell adhesivity and polymorphonuclear leukocyte ( PMN ) sequestration independently of de novo ICAM-1 synthesis . Positive_regulation SRC TNF 22846676 2646656 The observed inhibition of NCI-H838 cell migration by lidocaine and ropivacaine was associated with the inhibition of *induced* [Src-activation] and intercellular adhesion molecule-1 phosphorylation , providing the first evidence of a molecular mechanism that appears to be independent of their known role as sodium-channel blockers . Positive_regulation SRC TNF 24361597 2911232 Moreover , also time-dependently *stimulated* phosphorylation of c-Src and PDGFR and [c-Src/PDGFR] complex formation , which were reduced by pretreatment with PP1 or AG1296 . Positive_regulation SRC TNF 24502696 2914080 *stimulated* TNFR1 , TRAF2 , and [c-Src] complex formation was revealed by immunoprecipitation and Western blot . Positive_regulation SRC TNF 24525631 2938320 Endothelial barrier protection by local anesthetics : ropivacaine and lidocaine block induced endothelial cell [Src] *activation* . Positive_regulation SRC TNFSF10 22797920 2697119 Short-hairpin mediated silencing of RIP1 kinase prevented *induced* [Src] and STAT3 phosphorylation and reduced TRAIL induced migration and invasion of A549 cells . Positive_regulation SRC TNFSF10 24308965 2904857 HSP27 phosphorylation modulates induced *activation* of [Src-Akt/ERK] signaling through interaction with ß-arrestin2 . Positive_regulation SRC TNFSF10 24308965 2904868 Co-immunoprecipitation and confocal microscopy showed that HSP27 interacted with Src and scaffolding protein ß-arrestin2 in response of TRAIL stimulation and suppression of HSP27 phosphorylation apparently disrupted the *induced* interaction of HSP27 and [Src] or interaction of HSP27 and ß-arrestin2 . Positive_regulation SRC TNFSF10 24308965 2904870 We further demonstrated that ß-arrestin2 mediated HSP27 action on *induced* [Src] activation , which was achieved by recruiting signaling complex of HSP27/ß-arrestin2/Src in response to TRAIL . Positive_regulation SRCAP EGLN3 20858896 2342908 The C-terminal plant homeodomain (PHD) 2 and of Msc1 are *sufficient* to confer association with [Swr1] and allow Msc1 to function in the context of kinetochore mutants . Positive_regulation SREBF1 CLU 23515283 2772222 The present study examined whether *regulates* [SREBP-1c] expression and lipid accumulation in the liver . Positive_regulation SREBF1 EPHB2 21826653 2554525 Modulation of [SREBP-1] protein level by T ( 3 ) was *dependent* on , PI3K/Akt/mTOR-C1 pathway activation since the MEK inhibitor PD98059 or the PI3K inhibitor LY294002 abolished the stimulatory effect of T ( 3 ) . Positive_regulation SREBF1 IL1B 14748720 1204437 We have also demonstrated that both tumour necrosis factor alpha and *increased* nuclear [SREBP-1] levels by increasing SCAP mRNA expression , even in the presence of a high concentration of LDL . Positive_regulation SREBF1 PGC 21803289 2462279 Deletion of mIndy in mice ( mINDY ( -/- ) mice ) reduces hepatocellular ATP/ADP ratio , activates hepatic AMPK , *induces* , inhibits ACC-2 , and reduces [SREBP-1c] levels . Positive_regulation SREBF1 PGC 23300015 2818397 The transcriptional activation of is *necessary* and sufficient for the transcriptional activation of [SREBP-1] in response to RBP4 . Positive_regulation SREBF1 TNF 22305016 2565173 Suppression of phosphorylated JNK by the JNK inhibitor SP600125 greatly diminished *induced* expression of FAS and [SREBP-1] . Positive_regulation SREBF2 EPHB2 16211244 1464537 Collectively , these new findings establish an important role of ERK signaling pathway in SCAP ligand induced transcription of LDLR and imply that the protein synthesis or turnover rate of [SREBP-2] may be *regulated* by . Positive_regulation SREBF2 PGC 20953676 2375971 Additionally , *stimulates* the [SREBP2/HNF4a-] and PPARa/RXRa mediated transactivation of human NPC1L1 . Positive_regulation SRF EDN2 9765229 537919 We also found that the type 1 muscarinic receptor ( m1R ) and alpha1-adrenergic receptor ( AR ) -mediated SRF activation is exclusively dependent on Galphaq/11 , while the receptors for thrombin , lysophosphatidic acid (LPA) , thromboxane A2 , and can *activate* [SRF] in the absence of Galphaq/11 . Positive_regulation SRF EPHB2 19432968 2084103 Thrombin induces Egr-1 expression in fibroblasts involving elevation of the intracellular Ca2+ concentration , phosphorylation of and *activation* of [ternary complex] factor . Positive_regulation SRF EPHB2 21098124 2372035 Thus , signaling through the TCF pathway to SRF is *necessary* and sufficient for [SRF] function in thymocyte positive selection . Positive_regulation SRF HRH1 22100544 2534788 The results show that *mediated* activation of the strictly Rho dependent transcriptional activity of [serum response factor] requires the PDZ domain of LARG and can be mimicked by activated Ga ( q ) ( Q209L ) . Positive_regulation SRF NRARP 11485984 845013 We show that Nrarp forms a [ternary complex] with the ICD of XNotch1 and the CSL protein XSu ( H ) and that in embryos *promotes* the loss of ICD . Positive_regulation SRF TNF 24855642 2951106 We tested whether high insulin affects activation of *induced* NF-?B and [myocardin/serum response factor (SRF)] to convey hypertrophy signaling in cardiac myoblasts . Positive_regulation SRF TNF 24855642 2951114 Compared with insulin alone , *increased* [SRF/SRE] binding and ß-MHC expression , which was reversed by the NF-?B inhibitor pyrrolidine dithiocarbamate ( PDTC ) and by NF-?B silencing . Positive_regulation SRGN ADCY1 3514598 57804 This method was used to investigate the relationship between the rate of *activation* of by p ( NH ) [ppG] and GTP gamma S and their apparent affinities . Positive_regulation SRGN ADCY1 8489520 219321 At 35 degrees C , the addition of benzyl alcohol led to the apparent abolition of the lag period for p [ NH ] [ppG] *activation* of and amplified the steady-state rate by only around 2.2-fold . Positive_regulation SRGN ADCY10 3514598 57803 This method was used to investigate the relationship between the rate of *activation* of by p ( NH ) [ppG] and GTP gamma S and their apparent affinities . Positive_regulation SRGN ADCY10 8489520 219320 At 35 degrees C , the addition of benzyl alcohol led to the apparent abolition of the lag period for p [ NH ] [ppG] *activation* of and amplified the steady-state rate by only around 2.2-fold . Positive_regulation SRGN ADCY2 3514598 57805 This method was used to investigate the relationship between the rate of *activation* of by p ( NH ) [ppG] and GTP gamma S and their apparent affinities . Positive_regulation SRGN ADCY2 8489520 219322 At 35 degrees C , the addition of benzyl alcohol led to the apparent abolition of the lag period for p [ NH ] [ppG] *activation* of and amplified the steady-state rate by only around 2.2-fold . Positive_regulation SRGN ADCY3 3514598 57806 This method was used to investigate the relationship between the rate of *activation* of by p ( NH ) [ppG] and GTP gamma S and their apparent affinities . Positive_regulation SRGN ADCY3 8489520 219323 At 35 degrees C , the addition of benzyl alcohol led to the apparent abolition of the lag period for p [ NH ] [ppG] *activation* of and amplified the steady-state rate by only around 2.2-fold . Positive_regulation SRGN ADCY4 3514598 57807 This method was used to investigate the relationship between the rate of *activation* of by p ( NH ) [ppG] and GTP gamma S and their apparent affinities . Positive_regulation SRGN ADCY4 8489520 219324 At 35 degrees C , the addition of benzyl alcohol led to the apparent abolition of the lag period for p [ NH ] [ppG] *activation* of and amplified the steady-state rate by only around 2.2-fold . Positive_regulation SRGN ADCY5 3514598 57808 This method was used to investigate the relationship between the rate of *activation* of by p ( NH ) [ppG] and GTP gamma S and their apparent affinities . Positive_regulation SRGN ADCY5 8489520 219325 At 35 degrees C , the addition of benzyl alcohol led to the apparent abolition of the lag period for p [ NH ] [ppG] *activation* of and amplified the steady-state rate by only around 2.2-fold . Positive_regulation SRGN ADCY6 3514598 57809 This method was used to investigate the relationship between the rate of *activation* of by p ( NH ) [ppG] and GTP gamma S and their apparent affinities . Positive_regulation SRGN ADCY6 8489520 219326 At 35 degrees C , the addition of benzyl alcohol led to the apparent abolition of the lag period for p [ NH ] [ppG] *activation* of and amplified the steady-state rate by only around 2.2-fold . Positive_regulation SRGN ADCY7 3514598 57810 This method was used to investigate the relationship between the rate of *activation* of by p ( NH ) [ppG] and GTP gamma S and their apparent affinities . Positive_regulation SRGN ADCY7 8489520 219327 At 35 degrees C , the addition of benzyl alcohol led to the apparent abolition of the lag period for p [ NH ] [ppG] *activation* of and amplified the steady-state rate by only around 2.2-fold . Positive_regulation SRGN ADCY8 3514598 57811 This method was used to investigate the relationship between the rate of *activation* of by p ( NH ) [ppG] and GTP gamma S and their apparent affinities . Positive_regulation SRGN ADCY8 8489520 219328 At 35 degrees C , the addition of benzyl alcohol led to the apparent abolition of the lag period for p [ NH ] [ppG] *activation* of and amplified the steady-state rate by only around 2.2-fold . Positive_regulation SRGN ADCY9 3514598 57812 This method was used to investigate the relationship between the rate of *activation* of by p ( NH ) [ppG] and GTP gamma S and their apparent affinities . Positive_regulation SRGN ADCY9 8489520 219329 At 35 degrees C , the addition of benzyl alcohol led to the apparent abolition of the lag period for p [ NH ] [ppG] *activation* of and amplified the steady-state rate by only around 2.2-fold . Positive_regulation SRGN ADCYAP1 8653710 364648 In AR4-2J cells , ( 1-38 ) *increased* [PRG1] mRNA levels up to 10-fold in a rapid ( 30 min ) , transient ( 3-6 h ) , and dose dependent ( ED50 , < 1 nM ) fashion . Positive_regulation SRGN AGTR1 24508802 2918779 In the presence of [PPG] , NaHS .5mM , but not 0.1-0.3mM , *increased* T-currents in Cav3 .2-HEK293 cells . Positive_regulation SRGN CA2 3103379 67977 In addition , the activities of the [PRG] are inhibited by trypsin inhibitors , and this trypsin-like activity is *dependent* on . Positive_regulation SRGN CCK 3018365 62399 VIP alone ( 10 ( -11 ) to 10 ( -7 ) ) or alone ( 10 ( -9 ) ) did not significantly *stimulate* [PPG] secretion ( P greater than 0.05 ) . Positive_regulation SRGN CGA 6243282 10732 Lutropin-sensitive adenylate cyclase ( ( EC 4.6.1.1 ) ATP pyrophosphate-lyase ( cyclizing ) ) in purified rat ovarian plasma membranes is *stimulated* by 2- to 3-fold in the absence , but 15- to 20-fold in the presence of GTP or p ( NH ) [ppG] . Positive_regulation SRGN DNM1 14739229 1235028 The granzyme [B-serglycin] complex from cytotoxic granules *requires* for endocytosis . Positive_regulation SRGN DNM2 14739229 1235029 The granzyme [B-serglycin] complex from cytotoxic granules *requires* for endocytosis . Positive_regulation SRGN DNM3 14739229 1235027 The granzyme [B-serglycin] complex from cytotoxic granules *requires* for endocytosis . Positive_regulation SRGN ELL 20032306 2205153 When introduced in neurons , [PRG5] is distributed in the plasma membrane and *induces* filopodia as well as axon and growth . Positive_regulation SRGN GCG 2561940 126224 Hepatocyte membranes from both lean and obese Zucker rats exhibited adenylate cyclase activity that could be *stimulated* by , forskolin , NaF and elevated concentrations of p [ NH ] [ppG] . Positive_regulation SRGN GNRH1 7518388 261843 These findings indicate that *induced* [PRG] expression in gonadotrophs is mediated by protein kinase-C and calcium , and that protein kinase-C dependent induction of PRGs is modulated both positively and negatively by physiological changes in [ Ca2+ ] i . Positive_regulation SRGN IL10 16551363 1542055 [Ppg] stimulation *induced* primarily cytokine production , in addition to IFN-gamma , IL-13 and TNF-alpha secretion . Positive_regulation SRGN IL1A 24513305 2942591 Both LPS and *increased* the synthesis and secretion of [serglycin] , while only IL-1ß increased serglycin mRNA expression . Positive_regulation SRGN LHB 6243282 10733 Lutropin-sensitive adenylate cyclase ( ( EC 4.6.1.1 ) ATP pyrophosphate-lyase ( cyclizing ) ) in purified rat ovarian plasma membranes is *stimulated* by 2- to 3-fold in the absence , but 15- to 20-fold in the presence of GTP or p ( NH ) [ppG] . Positive_regulation SRGN NEUROD6 18643870 1966850 [Prg1] is *regulated* by the basic helix-loop-helix transcription factor . Positive_regulation SRGN NEUROD6 18643870 1966852 [Prg1] expression *induced* by was confirmed in cultured rat cortical cells and PC12 cells analyzed by real-time quantitative PCR . Positive_regulation SRGN NEUROD6 18643870 1966853 Our results suggest that directly *regulates* [Prg1] expression and that the Math2-Prg1 cascade plays an important role in neurite outgrowth in PC12 cells . Positive_regulation SRGN SLC5A1 23911260 2830592 inhibition *reduces* [postprandial glucose (PPG)] levels and increases the release of gastrointestinal peptides such as glucagon-like peptide 1 (GLP-1) and peptide tyrosine tyrosine (PYY) , whereas SGLT2 inhibition results in increased urinary glucose excretion ( UGE ) . Positive_regulation SRGN TCEA1 20032306 2205152 When introduced in neurons , [PRG5] is distributed in the plasma membrane and *induces* filopodia as well as axon and growth . Positive_regulation SRGN TNF 11244505 792325 Here , we show that in HeLa cells *induces* expression of [p22PRG1/IEX-1] in an NF-kappaB dependent fashion . Positive_regulation SRGN TNF 11244505 792328 Blockade of NF-kappaB activation by various NF-kappaB inhibitors abolished *induced* [p22PRG1/IEX-1] expression and increased the sensitivity to apoptosis induced by TNFalpha , an activating Fas-antibody or the anti-cancer drug etoposide . Positive_regulation SRGN TNF 23376071 2747943 [Serglycin] was secreted from adipocytes , and *stimulated* its expression and secretion in adipocytes . Positive_regulation SRGN TP53 9627114 512004 Our data demonstrate that [p22/PRG1] transcription is *induced* by during p53 dependent cell cycle arrest and apoptosis . Positive_regulation SRGN TP53 9781666 540547 CAT-reporter gene assays show *transactivation* of the human [p22/PRG1] promoter by in Hep3B cells stably transfected with a temperature-sensitive mutant p53 , but not in p53-deficient Hep3B cells . Positive_regulation SRGN VIP 3018365 62397 Consequently , it was the purpose of this study to test whether ( acting through cAMP mediated systems ) could *augment* CCK-8 ( acting through calcium dependent systems ) -stimulated [PPG] secretion . Positive_regulation SRGN VIP 3018365 62398 alone ( 10 ( -11 ) to 10 ( -7 ) ) or CCK-8 alone ( 10 ( -9 ) ) did not significantly *stimulate* [PPG] secretion ( P greater than 0.05 ) . Positive_regulation SRL MAP2K6 19955189 2210210 The pathway inhibitor , U0126 , *reduced* the [SRL] , CsA , and CsA/SRL induced increase in TER . Positive_regulation SRM TNF 16360300 1566919 AMs were exposed in vitro to Standard Reference Material (SRM) DEP 2975 , SRM DEP 1650 , [SRM] 1975 ( a dichloromethane extract of SRM DEP 2975 ) and CB particles for 24 h. DEPs *induced* a decreased secretion of IL-8 , and PGE ( 2 ) in response to a subsequent LPS stimulation . Positive_regulation SRSF1 TNF 7536422 297243 ELISA and RT-PCR studies revealed that [rgp120SF2] *induced* IL-6 and in brain cultures ; Positive_regulation SRSF11 TNF 18258304 1884773 *induces* p42/p44 , [p54] and p38 MAPK kinase ; Positive_regulation SSB TNF 8134404 251725 One day after treatment with 125 micrograms TCDD/kg , *resulted* in 70 , 27 , 33 and 21 % decreases in [DNA-SSB] , mitochondrial and microsomal lipid peroxidation and PLC activation , respectively , relative to TCDD treated mice . Positive_regulation SST IL1B 1641074 194779 It has previously been shown that the cytokines interleukin-1 beta and interleukin-6 ( IL-1 beta and IL-6 ) stimulate directly the release of corticotrophin-releasing-hormone-41 from the rat hypothalamus in vitro , while can also *stimulate* the release of [somatostatin] . Positive_regulation SST TNF 8978352 408994 The aim of this study was to examine whether IL-8 and could *regulate* [somatostatin] release from isolated canine gastric D cells . Positive_regulation SSTR1 EPHB2 9892010 586577 The *activation* of by [SSTR1] increased the expression of the cyclin dependent protein kinase inhibitor p21 ( cip1/WAF1 ) . Positive_regulation ST13 TNF 2809197 121388 [P48] *induces* and IL-1 secretion by human monocytes . Positive_regulation ST14 MAP2K6 20971737 2348609 ErbB-2 enhanced [matriptase] activation was *suppressed* by a phosphatidylinositol 3-kinase inhibitor ( ie , LY294002 ) but not by a inhibitor ( ie , PD98059 ) . Positive_regulation ST14 PLAU 10962009 744772 *Activation* of hepatocyte growth factor and by [matriptase] , an epithelial membrane serine protease . Positive_regulation ST14 PLAU 14747469 1226285 Our data identify a novel *role* for [matriptase] for activation of receptor bound . Positive_regulation ST2 TNF 22101519 2514301 Flagellin , IL-13 and all significantly *increased* [GAL3ST2] , MUC2 , TFF3 and TLR5 expression , while only IL-13 increased RETNLB and CHST5 expression . Positive_regulation ST3 TNF 22691873 2633661 Herein , we show that the pro-inflammatory cytokine *increases* the expression of a2,3-sialyltransferase gene [ST3GAL4] , both in human bronchial mucosa and in A549 lung carcinoma cells . Positive_regulation ST3GAL1 TNF 17142966 1653790 stimulation *induced* the biphasic increases in expression of NFkappaB-p65 , [ST3Gal I] , FUT IV , ST3Gal IV and ST6GalNAc III mRNAs and the transient increase in expression of ST6Gal I mRNA and the decrease in ST3GalNAc IV mRNA . Positive_regulation ST3GAL1 TNF 17142966 1653802 Transcription activities of [ST3Gal I] reporter gene from nt -1050 5'-flanking region to translation initiation site which has consensus NFkappaB binding sites were *up-regulated* by stimulation with in HT-29 cells . Positive_regulation ST3GAL1 TNF 17142966 1653803 The results indicated that constitutive promoter activities were detected at nt -120 5'-flanking translation initiation site and *enhanced* [ST3Gal I] gene expression through NFkappaB binding sites in HT-29 cells . Positive_regulation ST3GAL4 BPI 8985203 409072 FMLP , [serum treated zymosan (STZ)] , and lipoteichoic acid (LTA) also *induced* release . Positive_regulation ST3GAL4 IL1B 10773364 686404 [STZ] *induced* a low production of interleukin (IL)-2 mRNAs , a mild increase in IL-1alpha and IL-6 mRNAs production , and a dramatic increase in IFN-gamma , , TNF-alpha , IL-12 and IL-2 receptor mRNAs , which correlated with positive PLN responses . Positive_regulation ST3GAL4 TNF 17142966 1653791 stimulation induced the biphasic *increases* in expression of NFkappaB-p65 , ST3Gal I , FUT IV , [ST3Gal IV] and ST6GalNAc III mRNAs and the transient increase in expression of ST6Gal I mRNA and the decrease in ST3GalNAc IV mRNA . Positive_regulation ST3GAL4 TNF 24099577 2888774 *induces* the expression of the sialyltransferase [ST3Gal IV] in human bronchial mucosa via MSK1/2 protein kinases and increases FliD/sialyl-Lewis ( x ) -mediated adhesion of Pseudomonas aeruginosa . Positive_regulation ST6GALNAC3 TNF 17142966 1653799 stimulation induced the biphasic *increases* in expression of NFkappaB-p65 , ST3Gal I , FUT IV , ST3Gal IV and [ST6GalNAc III] mRNAs and the transient increase in expression of ST6Gal I mRNA and the decrease in ST3GalNAc IV mRNA . Positive_regulation ST8SIA1 GNE 16847058 1606780 Cellular responses to the *mediated* changes in ST3Gal5 and [ST8Sia1] expression and GM3 and GD3 levels were investigated next . Positive_regulation STAR EPHB2 11410589 849745 We demonstrate that cyclic AMP induced steroid synthesis is dependent upon the phosphorylation and activation of ERKs and that activation results in enhanced phosphorylation of SF-1 and *increased* steroid production through increased transcription of the [StAR] gene . Positive_regulation STAR EPHB2 11410589 849757 Similarly , inhibition *led* to a reduction in the levels of FSK stimulated StAR mRNA , [StAR] protein , and steroid secretion . Positive_regulation STAR MAP2K6 16061232 1442093 The activation of JAK2 or apparently *mediated* the magnolol induced phosphorylation of CREB and the upregulation of [StAR] . Positive_regulation STAR TNF 18210233 1839089 At 1 : 15 molecular ratio , TGF-beta1 blocked the down-regulation of [StAR] expression *mediated* by . Positive_regulation STARD3 IL1B 11146166 758910 A total of 14 clones could be matched to known genes and were categorized into four groups : A ) transcription factors : prothymosin , CA150 , p78 serine/threonine kinase , *stimulating* gene , glucocorticoid receptor , [MLN64/CAB1] , gastrin binding protein , and polypeptide from glioblastoma ; Positive_regulation STARD5 IL1B 16123165 1482285 Inhibition of JNK or COX-2 activities prevents *induction* of IL and [StARD5] mRNAs and subsequent increases in StARD1 mRNA ( 24 h ) , indicating that these effects depend on the activation of both enzymes . Positive_regulation STAT1 EPHB2 10498647 647614 In the *presence* of the inhibitor , binding of the AP-1 complex and of [STAT1] to the related regulatory elements was inhibited . Positive_regulation STAT1 EPHB2 16051824 1438637 Several MAPK regulated host transcription factors such as c-Jun , STAT1alpha , MEF2 , c-Myc , ATF-2 and c-Fos were induced early during infection , and inhibition significantly *blocked* the c-Fos , c-Jun , c-Myc , and [STAT1alpha] activation in the infected cells . Positive_regulation STAT1 EPHB2 19472212 2102234 JAKs inhibitors suppressed IFN-gamma plus TNF-alpha induced production of CXCL10 in parallel with activation of STAT1 and NF-kappaB , while inhibitor *suppressed* production of CXCL10 as well as activation of NF-kappaB , but not that of [STAT1] . Positive_regulation STAT1 EPHB2 20424383 2247164 In conclusion , this study proposes an anti-inflammatory mechanism of alpha-viniferin , down regulating STAT-1-inducible inflammatory genes via inhibiting mediated [STAT-1] *activation* in IFN-gamma stimulated macrophages . Positive_regulation STAT1 EPHB2 20675591 2305355 In this study , we demonstrate that the IFN-gamma mediated phosphorylation of [STAT1] on Ser ( 727 ) , crucial for its maximal activity , was *attenuated* in human macrophages by pharmacological inhibition of . Positive_regulation STAT1 EPHB2 22634008 2614828 Moreover , sorafenib inhibited IFN-a induced oncogenic signaling of STAT3 , AKT and but not the *activation* of the tumor suppressor [STAT1] . Positive_regulation STAT1 EPHB2 23917355 2826003 Inhibition of Akt or activity *reduced* phosphorylation of STAT1 in Colon26L5-CUG2 cells whereas inhibition of p38 MAPK did not significantly decrease levels of [STAT1] phosphorylation , indicating that cell proliferation signals may be involved in CUG2 mediated activation of STAT1 . Positive_regulation STAT1 EPHB2 8900046 393372 In differentiated myotubes , LIF treatment resulted in the tyrosine phosphorylation of both STAT3 and STAT1 , but phosphorylation was not detectable , and bFGF treatment did not *lead* to [STAT1] or STAT3 tyrosine phosphorylation . Positive_regulation STAT1 IGFBP1 17719815 1866068 Further analyses revealed that IGFBP-3 , but not , could significantly *enhance* the weak tyrosine phosphorylation of [STAT1] induced by IFN-gamma ( 20 U/ml ) alone . Positive_regulation STAT1 IL1B 11034404 740730 attenuates IFN-alpha beta *induced* antiviral activity and [STAT1] activation in the liver : involvement of proteasome dependent pathway . Positive_regulation STAT1 IL1B 12219013 986600 The 2 groups of mice were analyzed for serum levels of interferon-gamma , tumor necrosis factor-alpha , and as well as *activation* of NFkappaB and [STAT1] , 2 proinflammatory transcription factors . Positive_regulation STAT1 IL1B 15308667 1303468 This activity of IL-1beta does not depend on *dependent* [STAT1-serine] phosphorylation but on NF-kappaB dependent gene induction . Positive_regulation STAT1 IL1B 18556347 1965902 The p38 MAPK inhibitor SB202190 suppressed IL-1beta- and IL-1beta plus leptin induced hBD-2 production , *induced* NF-kappaB activity , and leptin induced [STAT1] and STAT3 activity ; Positive_regulation STAT1 IL1B 18556347 1965917 *induced* serine phosphorylation of inhibitory kappaBalpha , [STAT1] , and STAT3 . Positive_regulation STAT1 IL1B 22126015 2514761 Detailed molecular analyses showed that *increased* expression of phosphorylated [STAT1] ( Tyr701 and Ser727 ) and STAT3 ( Tyr705 and Ser727 ) both in total cell lysates and nuclear lysates . Positive_regulation STAT1 IL6R 15284232 1296533 Work from Ian Kerr 's laboratory reveals that the gp130 linked , which usually activates STAT3 predominantly , *activates* [STAT1] efficiently when STAT3 is absent . Positive_regulation STAT1 IL6R 19933857 2172040 When tested on CD4 and CD8 T cells , p28/CLF induces *dependent* [STAT1] and STAT3 phosphorylation . Positive_regulation STAT1 MAP2K6 10514514 651914 Overexpression of wild-type p38 mitogen activated protein kinase and its upstream activator 6 ( MKK6 ) *resulted* in an enhanced [STAT1] tyrosine phosphorylation upon osmotic shock . Positive_regulation STAT1 MAP2K6 17274000 1697220 Inhibitors of PI3 K , p38 MAPK , and *suppressed* IL-18 plus IFN-gamma induced CXCL9 , CXCL10 , and CXCL11 production and NF-kappaB , [STAT1] , and IRF-1 activities . Positive_regulation STAT1 MAP2K6 19103208 2036300 Inhibitors of STAT1 , ( MEK ) ( PD98059 ) , and phosphatidyl inositol 3 kinase (PI3K) ( LY294002 ) , *blocked* gp120 induced [STAT1] activation and significantly diminished IL-8- , IL-6- , and gp120 induced monocyte adhesion and migration across in vitro BBB models . Positive_regulation STAT1 MAP2K6 23825585 2808736 inhibitors PD98059 and U0216 not only *inhibited* the phosphorylation of [STAT1] , but also abrogated dasatinib induced myeloid differentiation , suggesting that MEK/ERK dependent phosphorylation of STAT1 might be indispensable for the differentiating effect of dasatinib in AML cells . Positive_regulation STAT1 PLAU 10446176 636378 This new *induced* [Stat2-Stat1] heterodimer binds to GAS ( the interferon-gamma activation site ) distinct from the interferon stimulated response element to which the p48 protein containing complexes generally bind . Positive_regulation STAT1 PLAU 12920039 1173949 The VSMC receives the signal and *activates* the transcription factor [Stat1] that , in turn , mediates the antiproliferative effects . Positive_regulation STAT1 PLAU 17548050 1752079 We provide evidence that Tyk2 , but not Jak1 , mediates *induced* [Stat1] phosphorylation and VSMC growth inhibition and suggest a novel function for Tyk2 as an important modulator of the uPA directed VSMC functional behaviour at the place of injury . Positive_regulation STAT1 PLAU 9417082 480403 Using an electrophoretic mobility shift assay , we then demonstrated that [Stat1] is rapidly activated in *response* to stimulation with and specifically binds to the DNA regulatory elements GAS ( interferon-gamma activation site ) and ISRE ( interferon stimulated response element ) . Positive_regulation STAT1 PLAU 9974409 596527 Using electrophoretic mobility shift and supershift assays , we then demonstrated that [Stat1] is rapidly activated in endothelial cells in *response* to and ATF . Positive_regulation STAT1 RAB31 18208665 1857679 Moreover , the relative densities of electrophoretic bands showed that activation of pSTAT3 was more significant than [STAT1] *induced* by . Positive_regulation STAT1 STAT4 10644731 661364 Expression of murine Stat4 in the Stat1-deficient U3A and the Stat2-deficient U6A cell lines shows that IFN-alpha induced phosphorylation *requires* the presence of activated Stat2 but not [Stat1] . Positive_regulation STAT1 STK39 10924861 718439 Genistein , a tyrosine kinase inhibitor , H7 , a inhibitor , and PD 98059 , a MEK inhibitor , *prevented* the UVA induced enhancement of [STAT1] binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation STAT1 TLR7 12686553 1099875 *induced* phosphorylation of Ser-727 [STAT1] could be blocked by the selective p38 mitogen activated protein kinase inhibitor SB203580 . Positive_regulation STAT1 TLR7 16953975 1611016 Unlike other cell types , the p38 mitogen activated protein kinase was necessary , but not sufficient , for *induced* phosphorylation of Ser-727 [STAT1] in macrophages . Positive_regulation STAT1 TLR7 18083102 1834545 *induction* of [IFNAR-STAT1] signaling upregulates the TAM system , which in turn usurps the IFNAR-STAT1 cassette to induce the cytokine and TLR suppressors SOCS1 and SOCS3 . Positive_regulation STAT1 TNF 10454343 637711 We describe a novel mechanism of signaling interaction through which treatment *augments* interferon-gamma (IFN-gamma) induced [Stat1alpha] DNA binding complexes and transcriptional activation of a Stat binding element . Positive_regulation STAT1 TNF 10454343 637713 In TNF-alpha treated cells , IFN-gamma induced phosphorylation of Jak2 kinase is increased , Jak2 kinase activity is enhanced , and genetic studies indicate that *requires* Jak2 kinase activity to enhance [Stat1alpha] tyrosine phosphorylation . Positive_regulation STAT1 TNF 11438544 850376 Specific inhibition of PI3K abrogates IFN gamma induced , but not interleukin-1- or *induced* , phosphorylation of [STAT1] on serine and reduces STAT1 dependent transcription and gene expression by approximately 7-fold . Positive_regulation STAT1 TNF 12219013 986598 The 2 groups of mice were analyzed for serum levels of interferon-gamma , , and interleukin-1beta as well as *activation* of NFkappaB and [STAT1] , 2 proinflammatory transcription factors . Positive_regulation STAT1 TNF 12856330 1110596 IL-1 and *enhance* the serine phosphorylation of [Stat1] that occurs in response to interferon-gamma (IFN-gamma) and potentiate IFN-gamma mediated , Stat1-driven gene expression , thus contributing to the synergistic activities of these proinflammatory cytokines . Positive_regulation STAT1 TNF 14519761 1174275 In this study , in a time dependent manner activated both janus tyrosine kinase 1 and Tyk2 tyrosine kinase and *increased* the nuclear translocation of interferon-regulatory factor-1 , [STAT1] , and STAT2 in human airway smooth muscle cells . Positive_regulation STAT1 TNF 15199060 1281075 This difference seemed to be underlain by differential induction of signal transducers and activators of transcription ( STAT ) activation in that , whereas flagellin and seemed to be equipotent activators of p38 mitogen activated protein kinase and nuclear factor-kappaB , flagellin *induced* substantially higher levels of [STAT-1] and -3 tyrosine phosphorylation . Positive_regulation STAT1 TNF 16318585 1487702 Interestingly , IFN-gamma pretreatment of 2fTGH fibroblasts potentiates *induction* of [Stat1] DNA binding . Positive_regulation STAT1 TNF 16648019 1553276 Peptide YY attenuates [STAT1] and STAT3 activation *induced* by in acinar cell line AR42J . Positive_regulation STAT1 TNF 16648019 1553290 We hypothesized that would *induce* [STAT1] and STAT3 , and PYY would attenuate their transcription factor binding . Positive_regulation STAT1 TNF 16648019 1553307 In pancreatic acinar cells , *activated* [STAT1] and STAT3 , known mediators of inflammatory cytokines . Positive_regulation STAT1 TNF 16861340 1588889 Thus , knock-down of RAX expression by 80 % using small interfering RNA ( siRNA ) prevents *induced* PKR activation and eIF2alpha phosphorylation , IkappaB degradation , IRF-1 expression , and [STAT1] phosphorylation , resulting in enhanced murine embryonic fibroblast (MEF) cell survival . Positive_regulation STAT1 TNF 16928387 1632916 Furthermore , Paeonol reduced *induced* NF-kappaB transactivation and IFNgamma induced [STAT1] transactivation in CW-2 cells and also in Jurkat cells . Positive_regulation STAT1 TNF 17507688 1772751 IFN-gamma induced CD40 expression involves activation of [STAT-1alpha] as well as NF-kappaB *activation* through an autocrine response to IFN-gamma induced production . Positive_regulation STAT1 TNF 17878351 1796904 IFN-epsilon mediates *induced* [STAT1] phosphorylation and induction of retinoic acid-inducible gene-I in human cervical cancer cells . Positive_regulation STAT1 TNF 17878351 1796911 Our findings support a sequential mechanism whereby *leads* to stabilization of IFN-epsilon mRNA , increased IFN-epsilon synthesis , engagement of type I IFNRs , increased [STAT1] expression and phosphorylation , and up-regulation of RIG-I expression . Positive_regulation STAT1 TNF 17878383 1797023 Activation of NF-kappaB , STAT6 , and [STAT1] was *induced* in eosinophils by , IL-4 , and IFN-gamma , respectively . Positive_regulation STAT1 TNF 18678606 1973295 Consistent with these results , and PGE2 did not *induce* [Stat1] DNA binding to a standard Stat1 binding oligonucleotide . Positive_regulation STAT1 TNF 18678606 1973297 Instead , and PGE2 *increased* [Stat1] serine phosphorylation and Stat4 tyrosine phosphorylation and activated expression of the NF-kappaB and Stat1 target gene IFN regulatory factor 1 (IRF1) , which contributes to IFN responses . Positive_regulation STAT1 TNF 19576177 2111560 PGG significantly inhibited *induced* NF-kappaB activation as well as [STAT1] activation . Positive_regulation STAT1 TNF 20006573 2199869 Concomitantly , *induced* phosphorylation of [STAT1] at Tyr-701 by JAK1 facilitates its nuclear translocation and activation of CD40 through p300 recruitment and core Histone-3 acetylation . Positive_regulation STAT1 TNF 21116791 2350930 SFN inhibited IFN-? and *induced* NF-?B activation as well as [STAT1] activation . Positive_regulation STAT1 TNF 21843792 2468515 Additionally , PGEA inhibited the *induced* activation of NF-?B and [STAT1] and increased the expression of heme oxygenase-1 (HO-1) protein and mRNA . Positive_regulation STAT1 TNF 21953607 2539389 In RA PBMCs , [STAT-1] expression was *increased* not only by IFNs but also by . Positive_regulation STAT1 TNF 22121136 2548500 *induced* early interferon ( IFN ) ß expression and [STAT1] phosphorylation beginning at 3 h , which was blocked by CP-690,550 . Positive_regulation STAT1 TNF 22227193 2544570 Casuarinin significantly inhibited induced *activation* of NF-?B , [STAT1] , and p38 MAPK . Positive_regulation STAT1 TNF 23170143 2700341 Recent studies have shown that cerulein activated nicotinamide adenine dinucleotide phosphate oxidase elicits reactive oxygen species , which trigger the phosphorylation of the JAK1 , [STAT1] , and STAT3 proteins and *induce* the production of inflammatory cytokines , such as , interleukin (IL)-1ß , and IL-6 , in pancreatic acinar cells . Positive_regulation STAT1 TNF 8940176 399118 and interferon-gamma *induced* NF-kappaB ( p50/p65 ) and [STAT-1] , respectively , as assessed by gel shift assays . Positive_regulation STAT1 TNF 9758167 535968 The existence of a synergism between IFN-gamma and TNF-alpha in stimulating IRF-1 expression at the transcriptional level was supported by IRF-1 promoter analysis : IFN-gamma directly *induced* the binding of [STAT-1] homodimers to the GAS element , while NF-kappaB binding to the kappaB sequence was activated by only after IFN-gamma treatment . Positive_regulation STAT2 PLAU 10446176 636366 In this study , we demonstrate that Stat4 and [Stat2] , but not Stat3 , Stat5 , or Stat6 , are rapidly activated in *response* to . Positive_regulation STAT2 PLAU 10446176 636379 This new *induced* [Stat2-Stat1] heterodimer binds to GAS ( the interferon-gamma activation site ) distinct from the interferon stimulated response element to which the p48 protein containing complexes generally bind . Positive_regulation STAT2 STAT4 10644731 661365 Expression of murine Stat4 in the Stat1-deficient U3A and the Stat2-deficient U6A cell lines shows that IFN-alpha induced phosphorylation *requires* the presence of activated [Stat2] but not Stat1 . Positive_regulation STAT2 TNF 14519761 1174276 In this study , in a time dependent manner activated both janus tyrosine kinase 1 and Tyk2 tyrosine kinase and *increased* the nuclear translocation of interferon-regulatory factor-1 , STAT1 , and [STAT2] in human airway smooth muscle cells . Positive_regulation STAT3 CCND1 11279133 811825 Whereas *had* no effect on the steady-state level of [STAT3] proteins in the cytoplasm , it was found to reduce the STAT3 nuclear level in HepG2 cells . Positive_regulation STAT3 CCND1 12107100 963015 Moreover , a striking inverse correlation was noted between hepatocyte nuclear accumulation of [phospho-STAT-3] and DNA synthesis ( as assessed by bromodeoxyuridine labeling ) , as well as mRNA *induction* and protein expression . Positive_regulation STAT3 CCND1 17322172 1719827 Blockade of gp130/STAT-3 signaling via adenovirus mediated expression of dngp130 or dnSTAT-3 attenuated balloon injury induced [STAT-3] phosphorylation and *induction* , resulting in reduced smooth muscle cell migration from media to intima and decreased neointima formation . Positive_regulation STAT3 CCND1 18512153 1984085 This drug significantly reduced the up-regulations of , cyclin E , c-Myc , and Bcl-2 as well as the *activation* of [STAT3] in SEG-1 cells . Positive_regulation STAT3 CCND1 24499623 2884897 These findings may provide a novel linkage between the EGFR and [STAT3] signaling pathways and the *activation* of by LMP1 in the carcinogenesis of NPC . Positive_regulation STAT3 CHI3L1 21953450 2507271 Activation of [STAT3] by oncostatin M *induced* expression in astrocytes , whereas expression of a dominant negative STAT3 had a suppressive effect . Positive_regulation STAT3 CTGF 23108098 2721408 Taken together , these results indicate that thrombin might activate c-Src to induce JAK2 activation , which in turn , causes [STAT3] activation , and finally *induces* expression in human lung fibroblasts . Positive_regulation STAT3 CTGF 24005672 2856220 Transforming growth factor-ß ( TGF-ß ) -mediated expression in hepatic stellate cells *requires* [Stat3] signaling activation . Positive_regulation STAT3 DAPK1 23438478 2749035 This model suggests that *induced* conformational changes in the [STAT3 dimer] masked its nuclear localization signal . Positive_regulation STAT3 EPHB2 10521505 653172 Inhibitors of and p38 did not *inhibit* UV-induced [Stat3] serine phosphorylation , suggesting that neither of them is involved . Positive_regulation STAT3 EPHB2 11875080 936984 STAT1 serine phosphorylation was perturbed by inhibition of ERK and p38 pathways , whereas only inhibition of activation *blocked* [STAT3] serine phosphorylation in response to EPO . Positive_regulation STAT3 EPHB2 12763138 1093869 Erythropoietin induced serine 727 phosphorylation of [STAT3] in erythroid cells is *mediated* by a MEK- , , and MSK1 dependent pathway . Positive_regulation STAT3 EPHB2 15325847 1287278 We also found that WKYMVm stimulated extracellular signal regulated kinase ( ERK ) , and that activity is *required* for [STAT3] serine phosphorylation . Positive_regulation STAT3 EPHB2 16164983 1456394 Inhibition of signaling also significantly *reduced* cytokine induced DNA binding activities of [STAT 3] and PU.1 , transcription factors that have been implicated in myeloid differentiation . Positive_regulation STAT3 EPHB2 16905269 1614687 P2 receptors can couple to extracellular signal regulated protein kinases ( ERK ) and we found that inhibition of signaling *blocked* phosphorylation of [Ser727-STAT3] . Positive_regulation STAT3 EPHB2 19885032 2161012 In cultured Schwann cells , we noted that activation is *required* for the serine phosphorylation of [STAT3] by neuropoietic cytokine interleukin-6 (IL-6) . Positive_regulation STAT3 EPHB2 19885032 2161013 Serine phosphorylated STAT3 by IL-6 was transported into Schwann cell nuclei , thereby indicating that may *regulate* the transcriptional activity of [STAT3] via the induction of serine phosphorylation of STAT3 . Positive_regulation STAT3 EPHB2 19885032 2161021 Finally , we determined that the inhibition of *prevented* injury induced serine phosphorylation of [STAT3] in an ex-vivo explants culture of the sciatic nerves . Positive_regulation STAT3 EPHB2 21608020 2480929 Inhibition of STAT3 tyrosine phosphorylation was found to be achieved through suppression of Src , JAK1 , and JAK2 , while suppression of [STAT3] serine phosphorylation was *mediated* by inhibition of activation . Positive_regulation STAT3 EPHB2 24447911 2923048 Ang II induced miR-21 expression in primary mouse cardiac fibroblasts ( CFs ) via dependent AP-1 and [STAT3] *activation* , and while a miR-21 inhibitor reversed Ang II-induced RECK suppression , a miR-21 mimic inhibited both RECK expression and Ang II-induced CF migration . Positive_regulation STAT3 EPHB2 8900046 393373 In differentiated myotubes , LIF treatment resulted in the tyrosine phosphorylation of both STAT3 and STAT1 , but phosphorylation was not detectable , and bFGF treatment did not *lead* to STAT1 or [STAT3] tyrosine phosphorylation . Positive_regulation STAT3 FOXO1 12456685 1055061 The effect of *required* the presence of functional [STAT3] and was abrogated by the expression of dominant negative STAT3 mutants . Positive_regulation STAT3 GLP1R 22842565 2646604 Silencing of *suppressed* the GLP-1 induced [STAT3] activation . Positive_regulation STAT3 GPR115 17008315 1647484 Moreover , the removal of Galpha ( s ) by RNA interference significantly reduced the beta2-adrenergic receptor mediated STAT3 phosphorylations , denoting its capacity to regulate [STAT3] *activation* by a . Positive_regulation STAT3 GPR132 17008315 1647473 Moreover , the removal of Galpha ( s ) by RNA interference significantly reduced the beta2-adrenergic receptor mediated STAT3 phosphorylations , denoting its capacity to regulate [STAT3] *activation* by a . Positive_regulation STAT3 GPR87 17008315 1647553 Moreover , the removal of Galpha ( s ) by RNA interference significantly reduced the beta2-adrenergic receptor mediated STAT3 phosphorylations , denoting its capacity to regulate [STAT3] *activation* by a . Positive_regulation STAT3 HBEGF 15562758 1341249 The phosphatation of [STAT3] *induced* by but not by IL-6 was blocked by PD153035 . Positive_regulation STAT3 HBEGF 17822789 1817470 *induces* delayed [STAT3] activation via NF-kappaB mediated IL-6 secretion in vascular smooth muscle cell . Positive_regulation STAT3 HBEGF 17822789 1817474 More interestingly , ( 10 ng/ml ) *induced* a biphasic activation of [STAT3] ( early at 5 min and late at 60-120 min ) . Positive_regulation STAT3 HBEGF 17822789 1817475 Therefore , we tried to elucidate the underlying mechanism of this delayed [STAT3] *activation* by in VSMCs . Positive_regulation STAT3 HBEGF 17822789 1817483 Again , the late *activation* of [STAT3] by was abolished by both Bay117082 and IL-6 neutralizing antibody ( 1 microg/ml ) indicating IL-6 is a key molecule in the delayed activation of STAT3 by HB-EGF . Positive_regulation STAT3 HBEGF 17822789 1817485 In conclusion , IL-6 plays an important role in the delayed activation of [STAT3] and VSMC proliferation *induced* by . Positive_regulation STAT3 IL1B 11071643 748132 Exposing primary rat hepatocytes to *had* no effect on IL-6 mediated [STAT3] activation ; Positive_regulation STAT3 IL1B 14664905 1177722 In the same cell type neither *dependent* SAPK activation nor IL-6 induced [STAT3] phosphorylation is affected by the drug . Positive_regulation STAT3 IL1B 15613280 1357426 *induces* expression of leukemia inhibitory factor (LIF) and activation of [STAT3] via the MEK/ERK pathway . Positive_regulation STAT3 IL1B 15613280 1357430 This activation of STAT3 could be abrogated by treatment with anti-LIF neutralizing antibody or anti-gp130 blocking antibody , indicating that induction of LIF expression is sufficient and essential for [STAT3] *activation* by . Positive_regulation STAT3 IL1B 17663801 1780452 In *response* to , or IL10 , the levels of phosphorylated NF-kappaB and [STAT3] -- respectively -- increased significantly for all the studied cell types . Positive_regulation STAT3 IL1B 18556347 1965904 The p38 MAPK inhibitor SB202190 suppressed IL-1beta- and IL-1beta plus leptin induced hBD-2 production , *induced* NF-kappaB activity , and leptin induced STAT1 and [STAT3] activity ; Positive_regulation STAT3 IL1B 19666510 2125973 Similarly , Th17 cells produce IL-17A in *response* to and a [STAT3] activator and Th1 cells produce IFNgamma in response to IL-18 and a STAT4 inducer . Positive_regulation STAT3 IL1B 22126015 2514762 Detailed molecular analyses showed that *increased* expression of phosphorylated STAT1 ( Tyr701 and Ser727 ) and [STAT3] ( Tyr705 and Ser727 ) both in total cell lysates and nuclear lysates . Positive_regulation STAT3 IL6R 15284232 1296534 Work from Ian Kerr 's laboratory reveals that the gp130 linked , which usually *activates* [STAT3] predominantly , activates STAT1 efficiently when STAT3 is absent . Positive_regulation STAT3 IL6R 16432158 1516166 Epigenetic modification of SOCS-1 differentially regulates [STAT3] activation in *response* to and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas . Positive_regulation STAT3 IL6R 16540526 1537054 Differential expression of and CD130 *mediates* different [STAT-3] phosphorylation in CD4+CD25- and CD25high regulatory T cells . Positive_regulation STAT3 IL6R 19933857 2172042 When tested on CD4 and CD8 T cells , p28/CLF induces *dependent* STAT1 and [STAT3] phosphorylation . Positive_regulation STAT3 MAP2K6 12763138 1093876 Erythropoietin induced serine 727 phosphorylation of [STAT3] in erythroid cells is *mediated* by a , ERK- , and MSK1 dependent pathway . Positive_regulation STAT3 MAP2K6 15378007 1323954 Our results showed that 5 ( MEK5 ) was markedly *induced* ( more than 22-fold increase , P < 0.001 ) by [Stat3-C] expression . Positive_regulation STAT3 MAP2K6 16164983 1456400 Inhibition of signaling also significantly *reduced* cytokine induced DNA binding activities of [STAT 3] and PU.1 , transcription factors that have been implicated in myeloid differentiation . Positive_regulation STAT3 MAP2K6 16432158 1516212 Pharmacologic inhibitors of JAK and and expression of SOCS-1 following demethylation or transient transfection *inhibited* [STAT3] activation and cell proliferation and induced cell apoptosis in corresponding cell lines . Positive_regulation STAT3 MAP2K6 16432158 1516224 We conclude that SOCS-1 methylation status can differentially affect [STAT3] *activation* by IL-6R and EGFR through JAK or in different HNSCC and response to pharmacologic antagonists . Positive_regulation STAT3 MAP2K6 20979115 2479932 PD98059 , a inhibitor , and pertussis toxin , a Gi inhibitor , *attenuated* HDL- , S1P- , and rHDL-S1P induced [Stat3] phosphorylation , whereas LY294002 , a PI3K inhibitor , had no effect . Positive_regulation STAT3 PLAU 10068107 594061 This involves complex formation of the receptors with other plasma membrane components for MET ( in context of its receptor ) and *activation* of [STAT-3] for both receptors . Positive_regulation STAT3 PLAU 10446176 636367 In this study , we demonstrate that Stat4 and Stat2 , but not [Stat3] , Stat5 , or Stat6 , are rapidly activated in *response* to . Positive_regulation STAT3 PLAU 16751220 1605261 *induced* [Stat3-DNA] binding activity in a time dependent manner . Positive_regulation STAT3 PLAU 16751220 1605262 *induced* [Stat3] activation does not require uPA catalytic activity , as the uPA amino-terminal fragment alone was as potent as active two-chain uPA ( tcuPA ) in causing this effect . Positive_regulation STAT3 PLAU 16751220 1605264 Single-chain likewise *induced* tyrosine phosphorylation of [Stat3] to a similar extent as intact tcuPA . Positive_regulation STAT3 PLAU 16751220 1605266 Plasmin did not alter *induced* [Stat3] activation . Positive_regulation STAT3 PLAU 16751220 1605267 These results reveal for the first time that the interaction *leads* to activation of [Stat3] , independent of its catalytic activity but dependent on its interaction with its receptor , uPAR , leading to DNA synthesis in lung epithelial cells . Positive_regulation STAT3 RGS2 18314882 1912102 Moreover , overexpression of , a protein inhibitor of G ( q/11 ) signaling , *blocked* PE-induced [Stat3] phosphorylation and reporter activity . Positive_regulation STAT3 RGS2 23238822 2769152 knock-down elevated Pam3 CSK4 induced STAT3 phosphorylation , but RGS2 overexpression *had* the opposite effect on [STAT3] phosphorylation . Positive_regulation STAT3 SPHK1 25197261 2958071 overexpression also *increased* IL-6 concentration and EGF induced [STAT3] phosphorylation , exemplifying that SphK1 modulates IL-6/STAT3 signaling . Positive_regulation STAT3 STK39 17353274 1734030 Here , we demonstrate that Stat3 is required for the Epo independent growth of Friend virus infected cells and that the *activation* of [Stat3] by is mediated by a novel Stat3 binding site in Gab2 . Positive_regulation STAT3 STK39 18426800 1932431 Docetaxel activates [STAT3] phosphorylation and transcriptional activity , which in turns *induces* expression of the PIM1 gene , encoding a activated by many cellular stresses . Positive_regulation STAT3 STK39 19581930 2136935 We demonstrate here that *activation* of [Stat3] by in the early stage of disease is essential for the progression of erythroleukemia in the presence of differentiation signals induced by the EpoR , but is dispensable in the late stages of the disease . Positive_regulation STAT3 TLR7 23023703 2706418 Furthermore , ligation *induced* [STAT3] activation and interfaced with Notch as well as canonical NF-?B and MAP kinase pathways , but downregulated expression of Notch target genes . Positive_regulation STAT3 TLR7 24043893 2851720 We further demonstrate that stimulation of human B cells with IL-21 and or TLR9 agonists *increases* the phosphorylation of [STAT3] , whereas the activation of NF-?B is not affected . Positive_regulation STAT3 TNF 10347215 616822 Herein , we demonstrate that the ability of IL-10 to inhibit production in lipopolysaccharide stimulated macrophages *requires* the presence of [Stat3] , Jak1 , and two distinct regions of the IL-10 receptor intracellular domain . Positive_regulation STAT3 TNF 10616907 575891 We conclude that NFkappaB is an essential component of the TNF proliferative pathway and that *induced* changes in IL-6 mRNA , [STAT3] , and c-myc mRNA are dependent on NFkappaB activation . Positive_regulation STAT3 TNF 11416024 829225 Immunoblot analysis of hypothalamic lysates with a phospho-specific STAT3 antibody showed a 6- to 7-fold stimulation of [STAT3] tyrosine phosphorylation in *response* to both leptin and . Positive_regulation STAT3 TNF 11801527 902542 *activates* [Jak1/Stat3-Stat5B] signaling through TNFR-1 in human B cells . Positive_regulation STAT3 TNF 15199060 1281076 This difference seemed to be underlain by differential induction of signal transducers and activators of transcription ( STAT ) activation in that , whereas flagellin and seemed to be equipotent activators of p38 mitogen activated protein kinase and nuclear factor-kappaB , flagellin *induced* substantially higher levels of [STAT-1 and -3] tyrosine phosphorylation . Positive_regulation STAT3 TNF 15893771 1419772 LPS and *activated* [STAT3] and SOCS3 in pancreatic acinar cells . Positive_regulation STAT3 TNF 16141211 1467202 Differences in *induced* [STAT3/DNA] binding activity and not NFkappaB and AP-1 transcriptional activation correlated with impaired collagen accumulation/TIMP-1 induction in TNFR2 ( -/- ) cells . Positive_regulation STAT3 TNF 16344382 1491993 Because *activates* the signal transducer and activator of transcription-3 ( [STAT-3] ) , we hypothesized that TNF-alpha induced preconditioning requires phosphorylation of STAT-3 rather than involving the classic prosurvival kinases , Akt and extracellular signal regulated kinase ( Erk ) 1/2 , during early reperfusion . Positive_regulation STAT3 TNF 16648019 1553277 Peptide YY attenuates STAT1 and [STAT3] activation *induced* by in acinar cell line AR42J . Positive_regulation STAT3 TNF 16648019 1553291 We hypothesized that would *induce* STAT1 and [STAT3] , and PYY would attenuate their transcription factor binding . Positive_regulation STAT3 TNF 16648019 1553308 In pancreatic acinar cells , *activated* STAT1 and [STAT3] , known mediators of inflammatory cytokines . Positive_regulation STAT3 TNF 18948191 1982307 In conclusion , The and IL-6 signals from the blood are necessary for liver regeneration and NF-kappaB and [STAT3] binding are *activated* via TNF-alpha and IL-6 signal pathways . Positive_regulation STAT3 TNF 20205746 2229743 *induced* phosphorylation of [STAT3] . Positive_regulation STAT3 TNF 20205746 2229747 The Janus family of tyrosine kinase (JAK) inhibitor I , an inhibitor of JAK 1 , 2 and 3 , attenuated *induced* phosphorylation of [STAT3] and significantly reduced TNF-alpha stimulated IL-6 release . Positive_regulation STAT3 TNF 22120492 2542162 Administration of the ROS scavenger catalase ( 2,000 U/ml ) remarkably inhibited induced cell proliferation and [STAT3] *activation* . Positive_regulation STAT3 TNF 23070544 2703397 also acutely *increased* LEPRb cell surface expression and leptin induced [STAT3] phosphorylation . Positive_regulation STAT3 TNF 23170143 2700344 Recent studies have shown that cerulein activated nicotinamide adenine dinucleotide phosphate oxidase elicits reactive oxygen species , which trigger the phosphorylation of the JAK1 , STAT1 , and [STAT3] proteins and *induce* the production of inflammatory cytokines , such as , interleukin (IL)-1ß , and IL-6 , in pancreatic acinar cells . Positive_regulation STAT3 TNF 23178521 2723698 Our data show that anatabine prevents [STAT3] and NF?B phosphorylation *induced* by lipopolysaccharide (LPS) or in SH-SY5Y , HEK293 , human microglia and human blood mononuclear cells . Positive_regulation STAT3 TNF 23236394 2708385 We found that *activated* [STAT3] at delayed time points ( 6 h and 24 h ) , whereas conditioned medium collected from TNF-a treated NPCs induced an immediate STAT3 activation . Positive_regulation STAT3 TNF 23236394 2708386 TNF-a induced STAT3 phosphorylation and astrogliogenesis were abrogated by the addition of neutralizing antibody for LIF , but not for IL-6 , revealing a critical role of autocrine secretion of LIF in induced [STAT3] *activation* and astrogliogenesis . Positive_regulation STAT3 TNF 23438478 2749031 We identified a new function of DAPK in suppressing *induced* [STAT3] activation as DAPK siRNA knockdown and treatment with a DAPK inhibitor potentiated STAT3 activation , IL-6 mRNA expression , and secretion . Positive_regulation STAT3 TNF 23817415 2815767 As in the case of IL-6 stimuli , Y14 enhanced *induced* [STAT3] phosphorylation , which is important for its nuclear retention . Positive_regulation STAT3 TNF 23862224 2817451 + CAPE *induced* statistically lower expressions of IL-6 and [p-STAT3] than TNF-alpha alone ( P < 0.05 ) . Positive_regulation STAT3 TNF 23971732 2841244 In this study , we have identified a link between brain inflammation and the signal transducer and activator of transcription 3 ( STAT3 ) pathway : IL-1ß and *induce* [STAT3] activation in NPCs . Positive_regulation STAT3 TNF 9794905 543191 The results demonstrate that transiently *activates* NF-kappaB and [STAT3] and increases the proliferative response of hepatocytes to HGF or TGF- by fourfold . Positive_regulation STAT3 TNFSF10 22797920 2697120 Short-hairpin mediated silencing of RIP1 kinase prevented *induced* Src and [STAT3] phosphorylation and reduced TRAIL induced migration and invasion of A549 cells . Positive_regulation STAT3 TP63 10878010 722380 Unlike p94 ( fer ) , ( ferT ) did not *induce* the phosphorylation of [Stat3] but led to the phosphorylation of other nuclear proteins . Positive_regulation STAT4 ATM 15000861 1216956 Apoptosis effected by TNF-alpha alone was suppressed by and this event was *paralleled* by phosphorylation and nuclear translocation of Jak2 , Stat2 , [Stat4] and NF-kB , along with inhibition of caspase activation . Positive_regulation STAT4 CD2 12731040 1086829 In LPMC , but not PBMC , *mediates* binding of STAT1 and [STAT4] to the IFN-gamma intronic element . Positive_regulation STAT4 CD28 20483042 2263267 In healthy individuals and adalimumab treated patients , *induced* the phosphorylation of [STAT4] , but not in untreated patients . Positive_regulation STAT4 CD4 10209051 607352 Both lineages require signal transducer and activator of transcription ( Stat ) 4 activation for IFN-gamma induced by interleukin (IL)-12/IL-18 signaling , but only ( + ) T cells *require* [Stat4] for IFN-gamma induction via the TCR pathway . Positive_regulation STAT4 CD4 10209051 607357 In response to antigen , CD8 ( + ) T cells can produce IFN-gamma independently of IL-12 , whereas ( + ) T cells *require* IL-12 and [Stat4] activation . Positive_regulation STAT4 CD40LG 20086239 2194580 By contrast , Toll-like receptor ligands and did not activate STAT6 in myeloid DCs , but instead *increased* the abundance of [STAT4] and IRF-8 to induce T(H)1 responses through the production of IL-12 . Positive_regulation STAT4 CD8A 17114431 1651449 IL-12 programmed long-term T cell responses *require* [STAT4] . Positive_regulation STAT4 CD8B 17114431 1651450 IL-12 programmed long-term T cell responses *require* [STAT4] . Positive_regulation STAT4 CSF2 9422769 481390 Furthermore , *induced* the tyrosine phosphorylation of STAT3 and STAT5 but not of STAT1 , STAT2 , [STAT4] , or STAT6 . Positive_regulation STAT4 EZH2 24141370 2878990 Unexpectedly , as a gene silencer , was *required* to promote the expression of transcription factors Tbx21 and [Stat4] . Positive_regulation STAT4 EZH2 24760151 2936867 inhibition *resulted* in significant decrease in the expression of Tbx21 and [Stat4] , which encode transcription factors T-bet and STAT4 , respectively . Positive_regulation STAT4 GADD45B 12213961 985798 We show here that and GADD45-gamma can *induce* [STAT4] S721 phosphorylation via the MKK6/p38 pathway . Positive_regulation STAT4 GADD45G 12213961 985799 We show here that GADD45-beta and can *induce* [STAT4] S721 phosphorylation via the MKK6/p38 pathway . Positive_regulation STAT4 HNRNPF 10861035 705119 Receptor engagement of as well as Con A blasts by IL-12 *resulted* in activation of Janus kinase 2 and Tyk2 kinases and Stat3 and [Stat4] transcription factors and the association of these proteins to IL-12Rbeta1 . Positive_regulation STAT4 HNRNPH1 10861035 705120 Receptor engagement of as well as Con A blasts by IL-12 *resulted* in activation of Janus kinase 2 and Tyk2 kinases and Stat3 and [Stat4] transcription factors and the association of these proteins to IL-12Rbeta1 . Positive_regulation STAT4 IFNA1 10644731 661348 Although Stat4 is activated by interleukin (IL)-12 in both human and murine T cells , [Stat4] is *activated* by only in human , but not murine , CD4 ( + ) T cells . Positive_regulation STAT4 IFNA1 15087447 1258037 but not interleukin 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IFNA10 10644731 661349 Although Stat4 is activated by interleukin (IL)-12 in both human and murine T cells , [Stat4] is *activated* by only in human , but not murine , CD4 ( + ) T cells . Positive_regulation STAT4 IFNA10 15087447 1258038 but not interleukin 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IFNA13 10644731 661350 Although Stat4 is activated by interleukin (IL)-12 in both human and murine T cells , [Stat4] is *activated* by only in human , but not murine , CD4 ( + ) T cells . Positive_regulation STAT4 IFNA13 15087447 1258039 but not interleukin 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IFNA14 10644731 661351 Although Stat4 is activated by interleukin (IL)-12 in both human and murine T cells , [Stat4] is *activated* by only in human , but not murine , CD4 ( + ) T cells . Positive_regulation STAT4 IFNA14 15087447 1258040 but not interleukin 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IFNA16 10644731 661352 Although Stat4 is activated by interleukin (IL)-12 in both human and murine T cells , [Stat4] is *activated* by only in human , but not murine , CD4 ( + ) T cells . Positive_regulation STAT4 IFNA16 15087447 1258041 but not interleukin 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IFNA17 10644731 661353 Although Stat4 is activated by interleukin (IL)-12 in both human and murine T cells , [Stat4] is *activated* by only in human , but not murine , CD4 ( + ) T cells . Positive_regulation STAT4 IFNA17 15087447 1258042 but not interleukin 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IFNA2 10644731 661354 Although Stat4 is activated by interleukin (IL)-12 in both human and murine T cells , [Stat4] is *activated* by only in human , but not murine , CD4 ( + ) T cells . Positive_regulation STAT4 IFNA2 15087447 1258043 but not interleukin 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IFNA21 10644731 661355 Although Stat4 is activated by interleukin (IL)-12 in both human and murine T cells , [Stat4] is *activated* by only in human , but not murine , CD4 ( + ) T cells . Positive_regulation STAT4 IFNA21 15087447 1258044 but not interleukin 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IFNA4 10644731 661356 Although Stat4 is activated by interleukin (IL)-12 in both human and murine T cells , [Stat4] is *activated* by only in human , but not murine , CD4 ( + ) T cells . Positive_regulation STAT4 IFNA4 15087447 1258045 but not interleukin 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IFNA5 10644731 661357 Although Stat4 is activated by interleukin (IL)-12 in both human and murine T cells , [Stat4] is *activated* by only in human , but not murine , CD4 ( + ) T cells . Positive_regulation STAT4 IFNA5 15087447 1258046 but not interleukin 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IFNA6 10644731 661358 Although Stat4 is activated by interleukin (IL)-12 in both human and murine T cells , [Stat4] is *activated* by only in human , but not murine , CD4 ( + ) T cells . Positive_regulation STAT4 IFNA6 15087447 1258047 but not interleukin 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IFNA7 10644731 661359 Although Stat4 is activated by interleukin (IL)-12 in both human and murine T cells , [Stat4] is *activated* by only in human , but not murine , CD4 ( + ) T cells . Positive_regulation STAT4 IFNA7 15087447 1258048 but not interleukin 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IFNA8 10644731 661360 Although Stat4 is activated by interleukin (IL)-12 in both human and murine T cells , [Stat4] is *activated* by only in human , but not murine , CD4 ( + ) T cells . Positive_regulation STAT4 IFNA8 15087447 1258049 but not interleukin 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IFNAR1 15611252 1357329 This finding suggests that , although the C terminus of human STAT2 is required for [STAT4] recruitment and *activation* by the human type I ( IFN-alphabetaR ) , it is not sufficient to restore this process through the murine IFNAR complex . Positive_regulation STAT4 IFNB1 12242445 989979 Here we show that *activate* [STAT4] directly ( STAT , signal transducers and activators of transcription ) and that this is required for IFN-gamma production during viral infections of mice , in concert with T cell receptor derived signals . Positive_regulation STAT4 IFNB1 16670125 1575298 Our aim was to investigate the effects of dexamethasone on [STAT4] *activation* by and IL-12 in human T cell blasts . Positive_regulation STAT4 IFNB1 16670125 1575301 We report that dexamethasone decreases IL-12 induced STAT4 phosphorylation and IFN-gamma production and enhances *induced* [STAT4] activation and IL-10 production . Positive_regulation STAT4 IFNB1 17095088 1667559 Although IL-12 induced STAT4 activation is a conserved pathway across species , *dependent* [STAT4] phosphorylation does not occur as efficiently in mice as it does in human T cells . Positive_regulation STAT4 IFNB1 17095088 1667562 In order to understand this species-specific pathway for *dependent* [STAT4] activation , we have examined the molecular basis of STAT4 recruitment by the human IFNAR . Positive_regulation STAT4 IFNB1 17351016 1741149 We report that *increases* IL-12 induced [STAT4] phosphorylation and up-regulates IL-12 receptor beta1 and beta2 expression . Positive_regulation STAT4 IFNB1 9862683 556027 The molecular basis for this species specificity is that *activate* [Stat4] in differentiating human , but not mouse , Th cells . Positive_regulation STAT4 IFNB1 9862683 556028 Unlike IL-12 , which acts only on Th1 cells , can *activate* [Stat4] not only in human Th1 , but also in Th2 cells . Positive_regulation STAT4 IFNG 11120802 758226 Since the precise role of Stat4 in IFN-gamma induction has not been established , experiments were conducted to examine [Stat4] *activation* of and other genes required for cytokine induced expression of IFN-gamma . Positive_regulation STAT4 IFNG 11207258 786864 The production of by IL-12/IL-18 activated macrophages *requires* [STAT4] signaling and is inhibited by IL-4 . Positive_regulation STAT4 IFNG 11466347 839905 An absolute requirement for [STAT4] and a *role* for as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex . Positive_regulation STAT4 IFNG 11476770 841929 Tyrosine phosphorylation of STAT 1 in capacitated sperm was enhanced by IFN-alpha and , and that of [STAT 4] was *enhanced* by IL-12 . Positive_regulation STAT4 IFNG 15470043 1317887 Findings indicate that these ODN inhibit *induced* STAT1 phosphorylation and IL-12 induced STAT3 and [STAT4] phosphorylation . Positive_regulation STAT4 IFNG 15817683 1432417 production in response to IL-12 plus IL-18 did not *require* increased expression of [STAT4] but was dependent on the activity of p38 mitogen activated protein kinase (MAPK) . Positive_regulation STAT4 IFNG 17015705 1629843 However , in differentiated Th1 cells , IFN-alpha can induce transient , but not sustained , [STAT4] phosphorylation and , in synergy with IL-18 , can *induce* transient , but not sustained , production in Th1 cells , in contrast to the sustained actions of IL-12 . Positive_regulation STAT4 IFNL1 15166220 1273394 Here , we show that activation of this receptor by can also inhibit cell proliferation and *induce* [STAT4] phosphorylation , further extending functional similarities with type I IFNs . Positive_regulation STAT4 IL10 10961885 726572 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL10 11894097 920690 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective induced [Stat4] *activation* . Positive_regulation STAT4 IL10 15087447 1258050 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL10 18988675 2034942 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL10 7638186 317647 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL11 10961885 726573 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL11 11894097 920691 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective *induced* [Stat4] activation . Positive_regulation STAT4 IL11 15087447 1258051 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL11 18988675 2034943 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL11 7638186 317648 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL12A 10029570 591649 Electrophoretic mobility shift assay indicated that TGF-beta induced a decrease in *induced* [STAT4] DNA binding activity in T lymphocytes . Positive_regulation STAT4 IL12A 10229872 611258 Inhibition of either Jak-2 or Tyk-2 leads to a decrease in the *induced* tyrosine phosphorylation of Stat3 , but not of [Stat4] , protein . Positive_regulation STAT4 IL12A 10415122 631205 When this phosphopeptide was introduced into TALL-104 cells , it blocked *induced* [STAT4] phosphorylation by competing with the IL-12 receptor for binding to STAT4 . Positive_regulation STAT4 IL12A 10491012 645886 Th2 T cells express only the IL-12R beta 1 and thus do not tyrosine phosphorylate [STAT4] in *response* to . Positive_regulation STAT4 IL12A 10566142 567453 signaling *results* in [STAT4] activation and interferon (IFN)-gamma production . Positive_regulation STAT4 IL12A 10586050 571646 Lisofylline also inhibited *induced* increases in [STAT4] tyrosine phosphorylation , but did not block TCR signaling or inhibit acquisition of IL-12 responsiveness . Positive_regulation STAT4 IL12A 10644731 661361 Although [Stat4] is *activated* by in both human and murine T cells , Stat4 is activated by interferon (IFN)-alpha only in human , but not murine , CD4 ( + ) T cells . Positive_regulation STAT4 IL12A 10657623 664065 Inhibition of Th1 immune response by glucocorticoids : dexamethasone selectively inhibits *induced* [Stat4] phosphorylation in T lymphocytes . Positive_regulation STAT4 IL12A 10657623 664075 However , dexamethasone markedly inhibited *induced* phosphorylation of [Stat4] without altering its expression . Positive_regulation STAT4 IL12A 10657623 664078 We conclude that blocking *induced* [Stat4] phosphorylation , without altering IL-4 induced Stat6 phosphorylation , appears to be a new suppressive action of glucocorticoids on the Th1 cellular immune response and may help explain the glucocorticoid induced shift toward the Th2 humoral immune response . Positive_regulation STAT4 IL12A 10706670 673210 Thus , although the IL-12R beta 2 and *dependent* [STAT4] activation are required for Th1 responses , activation of this pathway is not sufficient to restore a Th1 phenotype in developing or committed Th2 cells . Positive_regulation STAT4 IL12A 10779770 687496 Monocyte expressed [Stat4] in humans is phosphorylated in *response* to IFN-alpha , but not . Positive_regulation STAT4 IL12A 10820390 694502 selectively *regulates* [STAT4] via phosphatidylinositol 3-kinase and Ras independent signal transduction pathways . Positive_regulation STAT4 IL12A 10820390 694506 *induces* sustained activation and nuclear translocation of [STAT4] and this regulatory process is coupled to both tyrosine and serine phosphorylation of this molecule . Positive_regulation STAT4 IL12A 10820390 694521 This reveals that the STAT1 , 3 and 4 serine kinases are not coordinately regulated in human T cells and that must *regulate* serine phosphorylation of [STAT4] by a kinase network distinct to the MAPK Erk1 ,2 or PI3K pathways . Positive_regulation STAT4 IL12A 10961885 726589 Here we show that *induces* [STAT4] phosphorylation on serine 721 and that mutation of serine 721 interferes with STAT4 transcriptional activity . Positive_regulation STAT4 IL12A 10961885 726591 Although the site surrounding serine 721 is an optimum consensus sequence for mitogen activated family of protein kinases ( MAPKs ) -mediated phosphorylation , we demonstrate that IL-12 does not induce extracellular signal regulated kinase ( ERK ) or c-Jun N-terminal kinase (JNK) activation in T and natural killer ( NK ) cells and that *induced* [STAT4] transcriptional activity is not affected by these kinases . Positive_regulation STAT4 IL12A 10975850 729458 Attenuated IL-12Rbeta2 mRNA expression correlated with reduced receptor signaling , as demonstrated by reduced *induced* [STAT4] phosphorylation in enriched T lymphocytes isolated from the mesenteric lymph nodes and spleens of Salmonella infected mice . Positive_regulation STAT4 IL12A 11054278 745374 Although purified resting T cells were largely nonresponsive to IL-12 stimulation , anti-CD3 activated T cell blasts were strongly responsive , as demonstrated by the ability of to *induce* [Stat4] DNA binding activity . Positive_regulation STAT4 IL12A 11120802 758221 [Stat4] is activated in *response* to . Positive_regulation STAT4 IL12A 11120802 758232 Thus , [Stat4] *activation* by is required for the function of multiple cytokine pathways that result in induction of IFN-gamma . Positive_regulation STAT4 IL12A 11180102 784870 *induced* IFN-gamma production and [STAT4] nuclear translocation were markedly reduced in CD28 ( -/- ) splenocytes compared to that of wild-type ( WT ) splenocytes . Positive_regulation STAT4 IL12A 11359632 765292 This process is initiated by stimulation with antigen and the cytokines IL-12 and IL-4 , respectively , and requires antigen induced transcription factors such as NFAT and cytokine induced transcription factors such as [STAT4] , *induced* by , and STAT6 , induced by IL-4 . Positive_regulation STAT4 IL12A 11389027 822019 This down-regulation of STAT4 is specific for IL-12 signaling , presumably owing to the prolonged activation of [STAT4] *induced* by . Positive_regulation STAT4 IL12A 11441083 833397 Furthermore , *induced* [Stat4] phosphorylation and DNA binding in M. leprae activated T cells from tuberculoid but not from lepromatous patients . Positive_regulation STAT4 IL12A 11476770 841930 Tyrosine phosphorylation of STAT 1 in capacitated sperm was enhanced by IFN-alpha and IFN-gamma , and that of [STAT 4] was *enhanced* by . Positive_regulation STAT4 IL12A 11745339 888854 *induced* tyrosine phosphorylation and nuclear translocation of [STAT4] . Positive_regulation STAT4 IL12A 11801649 902565 Synergy of IL-12 and IL-18 for IFN-gamma gene expression : *induced* [STAT4] contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18 induced activator protein 1 . Positive_regulation STAT4 IL12A 11994496 939088 We conclude that the increased susceptibility of female NOD mice to the development of autoimmune diabetes could be due to the enhancement of the Th1 immune response through the increase of *induced* [STAT4] activation by estrogen . Positive_regulation STAT4 IL12A 12123550 965455 alone *induced* the phosphorylation of STAT3 and [STAT4] in PBMCs from patients with SLE , especially in active SLE . Positive_regulation STAT4 IL12A 12147631 970075 Decreased *induced* [STAT4] phosphorylation was also observed . Positive_regulation STAT4 IL12A 12147631 970077 Moreover , *dependent* transcriptional up-regulation of T-bet and [STAT4] was deficient in the HSA ( + ) CD4 SP thymocytes . Positive_regulation STAT4 IL12A 12407025 1010098 Since *induced* [STAT4] and IL-4 induced STAT6 activation is sustained in SOCS-1 ( -/- ) T cells , the enhanced T ( h ) functions in SOCS-1 ( -/- ) and SOCS-1 ( +/- ) mice appear to be due to the enhanced effects of these cytokines . Positive_regulation STAT4 IL12A 12458040 1021582 In vitro , *induces* the phosphorylation and nuclear localization of [STAT4] in neuroblastoma cell lines . Positive_regulation STAT4 IL12A 12637316 1099197 In exploring possible molecular mechanisms to account for the synergistic effects of IL-4 on murine NK cells , we found that IL-2 plus IL-4 stimulation resulted in a modest increase in tyrosine phosphorylation of Stat5 , while plus IL-4 treatment *resulted* in a more substantial increase in tyrosine phosphorylated [Stat4] . Positive_regulation STAT4 IL12A 12893768 1163948 On examining the effect of IL-12 on STAT4 and T-bet ( 2 key factors involved in IFN-gamma promoter activation ) , we found that *induced* the phosphorylation and nuclear translocation of [STAT4] . Positive_regulation STAT4 IL12A 14559241 1153809 SOCS-3 inhibits *induced* [STAT4] activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit . Positive_regulation STAT4 IL12A 14559241 1153811 Furthermore , SOCS-3 , but not its SH2 domain-defective mutant , inhibited the *induced* activation of DNA binding and transcriptional activities of [STAT4] . Positive_regulation STAT4 IL12A 14679102 1179076 Interruption of mediated [STAT4] *activation* prevented autoimmune diabetes in NOD mice . Positive_regulation STAT4 IL12A 14688310 1190438 The continuous presence of was *required* for sustained [STAT4] activation . Positive_regulation STAT4 IL12A 14734615 1199400 Here , we investigated the mechanism by which *activated* [STAT4] functions for IFN-gamma induction in TCR triggered T cells . Positive_regulation STAT4 IL12A 15004198 1217417 Impairment of *dependent* [STAT4] nuclear translocation in a patient with recurrent Mycobacterium avium infection . Positive_regulation STAT4 IL12A 15004198 1217419 Using EMSA , confocal laser microscopy , and Western blotting , we demonstrated that the nuclear translocation of [STAT4] in *response* to is reduced in PHA activated T cells from the patient when compared with those from healthy subjects . Positive_regulation STAT4 IL12A 15307169 1284810 We previously reported that , but not IFN-alphaA/D , *induces* T helper type (Th) 1 development and [STAT4] phosphorylation in murine CD4+ T cells . Positive_regulation STAT4 IL12A 15359113 1293577 In vitro treatment of activated T cells with quercetin blocks *induced* tyrosine phosphorylation of JAK2 , TYK2 , STAT3 , and [STAT4] , resulting in a decrease in IL-12 induced T cell proliferation and Th1 differentiation . Positive_regulation STAT4 IL12A 15611252 1357327 , but not IFN-alpha , *promotes* [STAT4] activation and Th1 development in murine CD4+ T cells expressing a chimeric murine/human Stat2 gene . Positive_regulation STAT4 IL12A 15634925 1362682 Interestingly , *induced* activation of Jak2 and [STAT4] , critical components for IL-12 mediated cellular responses , was shortened or attenuated in mutant T cells . Positive_regulation STAT4 IL12A 15778369 1384892 We also found that *induced* [Stat4] phosphorylation and Th1 cell differentiation were augmented in Stat5a ( -/- ) CD4 ( + ) T cells . Positive_regulation STAT4 IL12A 15778369 1384895 Importantly , the expression of suppressor of cytokine signaling (SOCS)3 , a potent inhibitor of *induced* [Stat4] activation , was decreased in Stat5a ( -/- ) CD4 ( + ) T cells . Positive_regulation STAT4 IL12A 16081070 1442787 [STAT4] is a transcription factor activated in *response* to , and is involved in Th1 cell development . Positive_regulation STAT4 IL12A 16301617 1485136 Mice deficient in [STAT4] lack *induced* IFN-gamma production and Th1 differentiation and display a predominantly Th2 phenotype . Positive_regulation STAT4 IL12A 16428084 1515873 Histamine did not affect *induced* phosphorylation of [STAT4] . Positive_regulation STAT4 IL12A 16466796 1534610 In keratinocytes , *activates* STAT3 and [STAT4] ; Positive_regulation STAT4 IL12A 16510856 1530537 Interestingly , no difference in PHA triggered signal transducer and activator of transcription 4 ( STAT4 ) phosphorylation between young and elderly donors was found , and a significant *induced* [STAT4] activation occurred only in PHA preactivated cells from the younger group . Positive_regulation STAT4 IL12A 16547967 1549756 Treatment of activated T cells with 1,25 ( OH ) 2D3 also inhibited the *induced* tyrosine phosphorylation of JAK2 , TYK2 , STAT3 , and [STAT4] in association with a decrease in T cell proliferation in vitro . Positive_regulation STAT4 IL12A 16670125 1575299 Our aim was to investigate the effects of dexamethasone on [STAT4] *activation* by IFN-beta and in human T cell blasts . Positive_regulation STAT4 IL12A 16670125 1575302 We report that dexamethasone decreases *induced* [STAT4] phosphorylation and IFN-gamma production and enhances IFN-beta induced STAT4 activation and IL-10 production . Positive_regulation STAT4 IL12A 16671324 1558569 SOCS3 controls *dependent* [STAT4] activation and Th2 differentiation process . Positive_regulation STAT4 IL12A 16849477 1588463 Indeed , in the present study we found that bone marrow derived DCs transduced with SOCS-3 significantly inhibited induced *activation* of [Stat4] and IL-23 induced activation of Stat3 . Positive_regulation STAT4 IL12A 17015705 1629839 In the present study , we compared the capacity of and IFN-alpha to *induce* Th1 differentiation , [STAT4] phosphorylation , and IFN-gamma production in murine T cells . Positive_regulation STAT4 IL12A 17095088 1667560 Although *induced* [STAT4] activation is a conserved pathway across species , IFN-alpha/beta dependent STAT4 phosphorylation does not occur as efficiently in mice as it does in human T cells . Positive_regulation STAT4 IL12A 17114431 1651453 Moreover , the *induced* [STAT4] engenders greater clonal expansion of the Ag-activated CD8 cells by regulating the expression of the transcriptional factor Bcl3- and Bcl2 related genes that promote survival of Ag-activated CD8 cells . Positive_regulation STAT4 IL12A 17351016 1741150 We report that IFN-beta increases *induced* [STAT4] phosphorylation and up-regulates IL-12 receptor beta1 and beta2 expression . Positive_regulation STAT4 IL12A 17395783 1760624 While the differentiation and maturation of DCs was normal in Tyk2-deficient ( Tyk2 ( -/- ) ) mice , *induced* [Stat4] phosphorylation was diminished in Tyk2 ( -/- ) DCs . Positive_regulation STAT4 IL12A 17785816 1790741 In this study , we found that although both IFN-alpha and can *promote* [STAT4] activation , IFN-alpha failed to promote Th1 commitment in human CD4+ T cells . Positive_regulation STAT4 IL12A 17979888 1820806 We report that curcumin decreases *induced* [STAT4] phosphorylation , IFN-gamma production , and IL-12 Rbeta1 and beta2 expression . Positive_regulation STAT4 IL12A 18048021 1836205 Increased expression and activation of *induced* [Stat4] signaling in the mucosa of ulcerative colitis patients . Positive_regulation STAT4 IL12A 18619507 1947382 Also , *augmented* the expression of cytotoxic effector molecules , TRAIL and perforin , and the phosphorylation of STAT1 , [STAT4] , and ERK1/2 , which may also contribute to lysis by NK cells . Positive_regulation STAT4 IL12A 18701445 2011791 Besides T cell receptor signaling , *induced* [STAT4] and T-bet- and IL-4 induced STAT6 and GATA3 signaling pathways are the major players regulating the Th1 and Th2 differentiation process , respectively . Positive_regulation STAT4 IL12A 18988675 2034959 The activation of [STAT4beta] was *mediated* by and not IFNgamma because deliberate addition or neutralization of IL-12 , but not IFNgamma , affected the activation of STAT4beta . Positive_regulation STAT4 IL12A 18988675 2034962 In contrast to *induced* activation of [STAT4beta] in cells from estrogen treated mice , STAT4alpha was not increased , rather it tended to be decreased . Positive_regulation STAT4 IL12A 19324016 2064556 While no significant difference was observed in the expression of IL-12Rbeta2 and STAT4 between STAT6 ( -/- ) T-bet ( -/- ) CD4 ( + ) T cells and T-bet ( -/- ) CD4 ( + ) T cells , *induced* [STAT4] phosphorylation was increased in STAT6 ( -/- ) T-bet ( -/- ) CD4 ( + ) T cells as compared with that in T-bet ( -/- ) CD4 ( + ) T cells . Positive_regulation STAT4 IL12A 19359411 2088821 *activates* [STAT4] , which is a critical regulator of inflammation and T helper type I (Th1) lineage development in murine systems . Positive_regulation STAT4 IL12A 19646904 2125370 We showed that development of IL-10 producing Th1 cells required high T cell receptor ( TCR ) ligation , sustained ERK1 and ERK2 MAP kinases phosphorylation , and *induced* [STAT4] transcription factor activation . Positive_regulation STAT4 IL12A 19740329 2134833 Furthermore , we demonstrate that induced [STAT-4] *activation* was required for T helper type 1 (Th1) cytokine induced IFN-gamma production in CD8 T cells . Positive_regulation STAT4 IL12A 20483042 2263262 Peripheral blood mononuclear cells ( PBMC ) were analysed flow cytometrically either directly after isolation or after 24 hours of anti-CD3/anti-CD28 stimulation , to determine spontaneous and *induced* [STAT4] and STAT6 phosphorylation in CD4+ T cells . Positive_regulation STAT4 IL12A 20593019 2285920 However , despite inducing up-regulation of these activation markers and , hence , delivering positive signals , prostate tumor cells inhibited the *induced* [STAT4] phosphorylation in a cell-cell contact dependent but CD1d independent manner . Positive_regulation STAT4 IL12A 20876105 2331966 Whereas the phosphorylation of [STAT4] was normally *induced* by stimulation , STAT4 was not recruited to the Ifng gene regions in Nfkbiz ( -/- ) NK cells . Positive_regulation STAT4 IL12A 21555485 2440876 Constitutive expression of high levels of IL-12 receptor by iNKT cells enabled instant *induced* [STAT4] activation , demonstrating that among T cells , iNKT cells are uniquely equipped for immediate , cytokine-driven activation . Positive_regulation STAT4 IL12A 21813204 2495448 Exposure of splenocytes to AEBSF for 3h noticeably inhibited the induction of IFN? , IL-12 , and *induced* [STAT4ß] , mRNA expression of T-bet and IL-12Rß2 . Positive_regulation STAT4 IL12A 22311028 2586375 [STAT4] and STAT6 were *activated* by and IL-4 stimulation , which were important for the generation of Th1 and Th2 cells . Positive_regulation STAT4 IL12A 23064011 2689955 Investigation into the signaling mechanism suggested that phosphorylation of [STAT-4] in *response* to was sustained for a longer duration in aged CD4+ T cells as compared to CD4+ T cells from young subjects . Positive_regulation STAT4 IL12A 24958858 2947366 Interrogation of mechanism showed that testosterone regulates T-helper 1 (Th1) differentiation by inhibiting *induced* [Stat4] phosphorylation : in murine models , we determined that androgen receptor binds a conserved region within the phosphatase , Ptpn1 , and consequent up-regulation of Ptpn1 then inhibits IL-12 signaling in CD4 T cells . Positive_regulation STAT4 IL12A 7638186 317690 In this report we demonstrate that *induces* tyrosine phosphorylation of a recently identified STAT family member , [STAT4] , and show that STAT4 expression is regulated by T-cell activation . Positive_regulation STAT4 IL12A 7760829 308002 In contrast , IL-2 , IL-3 , and erythropoietin induce the tyrosine phosphorylation of Stat5 while uniquely *induces* the tyrosine phosphorylation of [Stat4] . Positive_regulation STAT4 IL12A 8683106 370252 In contrast to IL-2 and IFN-alpha , *induced* strong tyrosine phosphorylation of [STAT4] and variable weak phosphorylation of STAT3 . Positive_regulation STAT4 IL12A 8683106 370256 However , supershift analyses using the c-fos promoter sis-inducible element probe showed that *activated* [STAT4] , STAT1 alpha , and STAT3 , and induced complexes containing STAT4 only , STAT4 with STAT1 alpha , STAT3 with STAT1 alpha , or STAT1 alpha only in preactivated primary NK cells . Positive_regulation STAT4 IL12A 8906805 394386 The IL-12 nonresponsiveness of the Th2 clones was further evident by the total lack of *induced* phosphorylation of [STAT4] ( signal transducer and activator of transcription-4 ) , a transcription factor that is typically involved in IL-12 signaling . Positive_regulation STAT4 IL12A 8943379 399996 *Activation* of [STAT4] by and IFN-alpha : evidence for the involvement of ligand induced tyrosine and serine phosphorylation . Positive_regulation STAT4 IL12A 8943379 400001 In this study , we demonstrated that [STAT4] *activation* by is not unique ; Positive_regulation STAT4 IL12A 8943379 400003 Thus , [STAT4] activation was not IL-12 specific , and and IFN-alpha *activated* STAT4 through both tyrosine and serine phosphorylation . Positive_regulation STAT4 IL12A 9079804 420708 One feature of Th2 differentiation in mice is the loss of *induced* Jak2 and [Stat4] activation , which is accompanied by the inability to produce IFN-gamma in response to IL-12 . Positive_regulation STAT4 IL12A 9257839 448532 The pattern of IL-12 responsiveness correlated with expression of the IL-12R signaling subunit , IL-12R beta2 , and with *induced* [STAT4] phosphorylation . Positive_regulation STAT4 IL12A 9454765 484362 The *induced* tyrosine phosphorylation of STAT5 and STAT1 , but not [STAT4] , is augmented in T cells activated into Th1 cells with PHA + interferon-gamma (IFN-gamma) compared with T cells activated with PHA alone . Positive_regulation STAT4 IL12A 9531298 496803 In Th1 cells , *activated* both STAT6 and [STAT4] , and IL-4 activated STAT6 , but in both cases the Th1 phenotype remained . Positive_regulation STAT4 IL12A 9574535 502526 Moreover , we showed that this increase in IFN-gamma could be explained by the dual *activation* of STAT1 and [STAT4] by IL-15 and , respectively . Positive_regulation STAT4 IL12A 9715265 527776 We demonstrate that *induces* [STAT4] only in freshly isolated primary NK cells , but not in primary T cells , consistent with the lack of the IL-12 receptor in resting T cells . Positive_regulation STAT4 IL12A 9886399 584683 This activation of [STAT4] in response to IL-2 is not *due* to the autocrine production of or IFN-alpha . Positive_regulation STAT4 IL12B 10029570 591650 Electrophoretic mobility shift assay indicated that TGF-beta induced a decrease in *induced* [STAT4] DNA binding activity in T lymphocytes . Positive_regulation STAT4 IL12B 10229872 611259 Inhibition of either Jak-2 or Tyk-2 leads to a decrease in the *induced* tyrosine phosphorylation of Stat3 , but not of [Stat4] , protein . Positive_regulation STAT4 IL12B 10415122 631206 When this phosphopeptide was introduced into TALL-104 cells , it blocked *induced* [STAT4] phosphorylation by competing with the IL-12 receptor for binding to STAT4 . Positive_regulation STAT4 IL12B 10491012 645887 Th2 T cells express only the IL-12R beta 1 and thus do not tyrosine phosphorylate [STAT4] in *response* to . Positive_regulation STAT4 IL12B 10566142 567454 signaling *results* in [STAT4] activation and interferon (IFN)-gamma production . Positive_regulation STAT4 IL12B 10586050 571647 Lisofylline also inhibited *induced* increases in [STAT4] tyrosine phosphorylation , but did not block TCR signaling or inhibit acquisition of IL-12 responsiveness . Positive_regulation STAT4 IL12B 10644731 661362 Although [Stat4] is *activated* by in both human and murine T cells , Stat4 is activated by interferon (IFN)-alpha only in human , but not murine , CD4 ( + ) T cells . Positive_regulation STAT4 IL12B 10657623 664066 Inhibition of Th1 immune response by glucocorticoids : dexamethasone selectively inhibits *induced* [Stat4] phosphorylation in T lymphocytes . Positive_regulation STAT4 IL12B 10657623 664076 However , dexamethasone markedly inhibited *induced* phosphorylation of [Stat4] without altering its expression . Positive_regulation STAT4 IL12B 10657623 664079 We conclude that blocking *induced* [Stat4] phosphorylation , without altering IL-4 induced Stat6 phosphorylation , appears to be a new suppressive action of glucocorticoids on the Th1 cellular immune response and may help explain the glucocorticoid induced shift toward the Th2 humoral immune response . Positive_regulation STAT4 IL12B 10706670 673211 Thus , although the IL-12R beta 2 and dependent [STAT4] *activation* are required for Th1 responses , activation of this pathway is not sufficient to restore a Th1 phenotype in developing or committed Th2 cells . Positive_regulation STAT4 IL12B 10779770 687497 Monocyte expressed [Stat4] in humans is phosphorylated in *response* to IFN-alpha , but not . Positive_regulation STAT4 IL12B 10820390 694503 selectively *regulates* [STAT4] via phosphatidylinositol 3-kinase and Ras independent signal transduction pathways . Positive_regulation STAT4 IL12B 10820390 694507 *induces* sustained activation and nuclear translocation of [STAT4] and this regulatory process is coupled to both tyrosine and serine phosphorylation of this molecule . Positive_regulation STAT4 IL12B 10820390 694522 This reveals that the STAT1 , 3 and 4 serine kinases are not coordinately regulated in human T cells and that must *regulate* serine phosphorylation of [STAT4] by a kinase network distinct to the MAPK Erk1 ,2 or PI3K pathways . Positive_regulation STAT4 IL12B 10961885 726590 Here we show that *induces* [STAT4] phosphorylation on serine 721 and that mutation of serine 721 interferes with STAT4 transcriptional activity . Positive_regulation STAT4 IL12B 10961885 726592 Although the site surrounding serine 721 is an optimum consensus sequence for mitogen activated family of protein kinases ( MAPKs ) -mediated phosphorylation , we demonstrate that IL-12 does not induce extracellular signal regulated kinase ( ERK ) or c-Jun N-terminal kinase (JNK) activation in T and natural killer ( NK ) cells and that *induced* [STAT4] transcriptional activity is not affected by these kinases . Positive_regulation STAT4 IL12B 10975850 729459 Attenuated IL-12Rbeta2 mRNA expression correlated with reduced receptor signaling , as demonstrated by reduced *induced* [STAT4] phosphorylation in enriched T lymphocytes isolated from the mesenteric lymph nodes and spleens of Salmonella infected mice . Positive_regulation STAT4 IL12B 11054278 745375 Although purified resting T cells were largely nonresponsive to IL-12 stimulation , anti-CD3 activated T cell blasts were strongly responsive , as demonstrated by the ability of to *induce* [Stat4] DNA binding activity . Positive_regulation STAT4 IL12B 11114383 757806 nonetheless , *activates* [Stat4] in PHA blast T cells . Positive_regulation STAT4 IL12B 11120802 758222 [Stat4] is activated in *response* to . Positive_regulation STAT4 IL12B 11120802 758233 Thus , [Stat4] *activation* by is required for the function of multiple cytokine pathways that result in induction of IFN-gamma . Positive_regulation STAT4 IL12B 11180102 784871 *induced* IFN-gamma production and [STAT4] nuclear translocation were markedly reduced in CD28 ( -/- ) splenocytes compared to that of wild-type ( WT ) splenocytes . Positive_regulation STAT4 IL12B 11359632 765293 This process is initiated by stimulation with antigen and the cytokines IL-12 and IL-4 , respectively , and requires antigen induced transcription factors such as NFAT and cytokine induced transcription factors such as [STAT4] , *induced* by , and STAT6 , induced by IL-4 . Positive_regulation STAT4 IL12B 11389027 822020 This down-regulation of STAT4 is specific for IL-12 signaling , presumably owing to the prolonged activation of [STAT4] *induced* by . Positive_regulation STAT4 IL12B 11441083 833398 Furthermore , *induced* [Stat4] phosphorylation and DNA binding in M. leprae activated T cells from tuberculoid but not from lepromatous patients . Positive_regulation STAT4 IL12B 11476770 841931 Tyrosine phosphorylation of STAT 1 in capacitated sperm was enhanced by IFN-alpha and IFN-gamma , and that of [STAT 4] was *enhanced* by . Positive_regulation STAT4 IL12B 11745339 888855 *induced* tyrosine phosphorylation and nuclear translocation of [STAT4] . Positive_regulation STAT4 IL12B 11801649 902566 Synergy of IL-12 and IL-18 for IFN-gamma gene expression : *induced* [STAT4] contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18 induced activator protein 1 . Positive_regulation STAT4 IL12B 11994496 939089 We conclude that the increased susceptibility of female NOD mice to the development of autoimmune diabetes could be due to the enhancement of the Th1 immune response through the increase of induced [STAT4] *activation* by estrogen . Positive_regulation STAT4 IL12B 12123550 965456 alone *induced* the phosphorylation of STAT3 and [STAT4] in PBMCs from patients with SLE , especially in active SLE . Positive_regulation STAT4 IL12B 12147631 970076 Decreased *induced* [STAT4] phosphorylation was also observed . Positive_regulation STAT4 IL12B 12147631 970078 Moreover , *dependent* transcriptional up-regulation of T-bet and [STAT4] was deficient in the HSA ( + ) CD4 SP thymocytes . Positive_regulation STAT4 IL12B 12407025 1010099 Since *induced* [STAT4] and IL-4 induced STAT6 activation is sustained in SOCS-1 ( -/- ) T cells , the enhanced T ( h ) functions in SOCS-1 ( -/- ) and SOCS-1 ( +/- ) mice appear to be due to the enhanced effects of these cytokines . Positive_regulation STAT4 IL12B 12458040 1021583 In vitro , *induces* the phosphorylation and nuclear localization of [STAT4] in neuroblastoma cell lines . Positive_regulation STAT4 IL12B 12637316 1099198 In exploring possible molecular mechanisms to account for the synergistic effects of IL-4 on murine NK cells , we found that IL-2 plus IL-4 stimulation resulted in a modest increase in tyrosine phosphorylation of Stat5 , while plus IL-4 treatment *resulted* in a more substantial increase in tyrosine phosphorylated [Stat4] . Positive_regulation STAT4 IL12B 12893768 1163949 On examining the effect of IL-12 on STAT4 and T-bet ( 2 key factors involved in IFN-gamma promoter activation ) , we found that *induced* the phosphorylation and nuclear translocation of [STAT4] . Positive_regulation STAT4 IL12B 14559241 1153810 SOCS-3 inhibits induced [STAT4] *activation* by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit . Positive_regulation STAT4 IL12B 14559241 1153812 Furthermore , SOCS-3 , but not its SH2 domain-defective mutant , inhibited the induced *activation* of DNA binding and transcriptional activities of [STAT4] . Positive_regulation STAT4 IL12B 14679102 1179077 Interruption of mediated [STAT4] *activation* prevented autoimmune diabetes in NOD mice . Positive_regulation STAT4 IL12B 14688310 1190439 The continuous presence of was *required* for sustained [STAT4] activation . Positive_regulation STAT4 IL12B 14734615 1199401 Here , we investigated the mechanism by which *activated* [STAT4] functions for IFN-gamma induction in TCR triggered T cells . Positive_regulation STAT4 IL12B 15004198 1217418 Impairment of *dependent* [STAT4] nuclear translocation in a patient with recurrent Mycobacterium avium infection . Positive_regulation STAT4 IL12B 15004198 1217420 Using EMSA , confocal laser microscopy , and Western blotting , we demonstrated that the nuclear translocation of [STAT4] in *response* to is reduced in PHA activated T cells from the patient when compared with those from healthy subjects . Positive_regulation STAT4 IL12B 15307169 1284811 We previously reported that , but not IFN-alphaA/D , *induces* T helper type (Th) 1 development and [STAT4] phosphorylation in murine CD4+ T cells . Positive_regulation STAT4 IL12B 15359113 1293578 In vitro treatment of activated T cells with quercetin blocks *induced* tyrosine phosphorylation of JAK2 , TYK2 , STAT3 , and [STAT4] , resulting in a decrease in IL-12 induced T cell proliferation and Th1 differentiation . Positive_regulation STAT4 IL12B 15611252 1357328 , but not IFN-alpha , *promotes* [STAT4] activation and Th1 development in murine CD4+ T cells expressing a chimeric murine/human Stat2 gene . Positive_regulation STAT4 IL12B 15634925 1362683 Interestingly , induced *activation* of Jak2 and [STAT4] , critical components for IL-12 mediated cellular responses , was shortened or attenuated in mutant T cells . Positive_regulation STAT4 IL12B 15778369 1384893 We also found that *induced* [Stat4] phosphorylation and Th1 cell differentiation were augmented in Stat5a ( -/- ) CD4 ( + ) T cells . Positive_regulation STAT4 IL12B 15778369 1384896 Importantly , the expression of suppressor of cytokine signaling (SOCS)3 , a potent inhibitor of *induced* [Stat4] activation , was decreased in Stat5a ( -/- ) CD4 ( + ) T cells . Positive_regulation STAT4 IL12B 16081070 1442788 [STAT4] is a transcription factor activated in *response* to , and is involved in Th1 cell development . Positive_regulation STAT4 IL12B 16301617 1485137 Mice deficient in [STAT4] lack *induced* IFN-gamma production and Th1 differentiation and display a predominantly Th2 phenotype . Positive_regulation STAT4 IL12B 16428084 1515874 Histamine did not affect *induced* phosphorylation of [STAT4] . Positive_regulation STAT4 IL12B 16466796 1534611 In keratinocytes , *activates* STAT3 and [STAT4] ; Positive_regulation STAT4 IL12B 16510856 1530538 Interestingly , no difference in PHA triggered signal transducer and activator of transcription 4 ( STAT4 ) phosphorylation between young and elderly donors was found , and a significant induced [STAT4] *activation* occurred only in PHA preactivated cells from the younger group . Positive_regulation STAT4 IL12B 16547967 1549757 Treatment of activated T cells with 1,25 ( OH ) 2D3 also inhibited the *induced* tyrosine phosphorylation of JAK2 , TYK2 , STAT3 , and [STAT4] in association with a decrease in T cell proliferation in vitro . Positive_regulation STAT4 IL12B 16670125 1575300 Our aim was to investigate the effects of dexamethasone on [STAT4] *activation* by IFN-beta and in human T cell blasts . Positive_regulation STAT4 IL12B 16670125 1575303 We report that dexamethasone decreases *induced* [STAT4] phosphorylation and IFN-gamma production and enhances IFN-beta induced STAT4 activation and IL-10 production . Positive_regulation STAT4 IL12B 16671324 1558570 SOCS3 controls *dependent* [STAT4] activation and Th2 differentiation process . Positive_regulation STAT4 IL12B 16849477 1588464 Indeed , in the present study we found that bone marrow derived DCs transduced with SOCS-3 significantly inhibited *induced* activation of [Stat4] and IL-23 induced activation of Stat3 . Positive_regulation STAT4 IL12B 17015705 1629840 In the present study , we compared the capacity of and IFN-alpha to *induce* Th1 differentiation , [STAT4] phosphorylation , and IFN-gamma production in murine T cells . Positive_regulation STAT4 IL12B 17095088 1667561 Although induced [STAT4] *activation* is a conserved pathway across species , IFN-alpha/beta dependent STAT4 phosphorylation does not occur as efficiently in mice as it does in human T cells . Positive_regulation STAT4 IL12B 17114431 1651454 Moreover , the *induced* [STAT4] engenders greater clonal expansion of the Ag-activated CD8 cells by regulating the expression of the transcriptional factor Bcl3- and Bcl2 related genes that promote survival of Ag-activated CD8 cells . Positive_regulation STAT4 IL12B 17351016 1741151 We report that IFN-beta increases *induced* [STAT4] phosphorylation and up-regulates IL-12 receptor beta1 and beta2 expression . Positive_regulation STAT4 IL12B 17395783 1760625 While the differentiation and maturation of DCs was normal in Tyk2-deficient ( Tyk2 ( -/- ) ) mice , *induced* [Stat4] phosphorylation was diminished in Tyk2 ( -/- ) DCs . Positive_regulation STAT4 IL12B 17785816 1790742 In this study , we found that although both IFN-alpha and can *promote* [STAT4] activation , IFN-alpha failed to promote Th1 commitment in human CD4+ T cells . Positive_regulation STAT4 IL12B 17979888 1820807 We report that curcumin decreases *induced* [STAT4] phosphorylation , IFN-gamma production , and IL-12 Rbeta1 and beta2 expression . Positive_regulation STAT4 IL12B 18048021 1836206 Increased expression and activation of *induced* [Stat4] signaling in the mucosa of ulcerative colitis patients . Positive_regulation STAT4 IL12B 18619507 1947383 Also , *augmented* the expression of cytotoxic effector molecules , TRAIL and perforin , and the phosphorylation of STAT1 , [STAT4] , and ERK1/2 , which may also contribute to lysis by NK cells . Positive_regulation STAT4 IL12B 18701445 2011792 Besides T cell receptor signaling , *induced* [STAT4] and T-bet- and IL-4 induced STAT6 and GATA3 signaling pathways are the major players regulating the Th1 and Th2 differentiation process , respectively . Positive_regulation STAT4 IL12B 18988675 2034960 The activation of [STAT4beta] was *mediated* by and not IFNgamma because deliberate addition or neutralization of IL-12 , but not IFNgamma , affected the activation of STAT4beta . Positive_regulation STAT4 IL12B 18988675 2034963 In contrast to induced *activation* of [STAT4beta] in cells from estrogen treated mice , STAT4alpha was not increased , rather it tended to be decreased . Positive_regulation STAT4 IL12B 19324016 2064557 While no significant difference was observed in the expression of IL-12Rbeta2 and STAT4 between STAT6 ( -/- ) T-bet ( -/- ) CD4 ( + ) T cells and T-bet ( -/- ) CD4 ( + ) T cells , *induced* [STAT4] phosphorylation was increased in STAT6 ( -/- ) T-bet ( -/- ) CD4 ( + ) T cells as compared with that in T-bet ( -/- ) CD4 ( + ) T cells . Positive_regulation STAT4 IL12B 19359411 2088822 *activates* [STAT4] , which is a critical regulator of inflammation and T helper type I (Th1) lineage development in murine systems . Positive_regulation STAT4 IL12B 19646904 2125371 We showed that development of IL-10 producing Th1 cells required high T cell receptor ( TCR ) ligation , sustained ERK1 and ERK2 MAP kinases phosphorylation , and induced [STAT4] transcription factor *activation* . Positive_regulation STAT4 IL12B 19740329 2134834 Furthermore , we demonstrate that *induced* [STAT-4] activation was required for T helper type 1 (Th1) cytokine induced IFN-gamma production in CD8 T cells . Positive_regulation STAT4 IL12B 20415779 2246549 binding to an IL-23 receptor expressed on dendritic cells , macrophages and monocytes triggers the activation of Jak2 and Tyk2 , which in turn phosphorylates STAT1 , STAT3 , STAT4 and STAT5 as well as *induce* formation of [STAT3-STAT4] heterodimers . Positive_regulation STAT4 IL12B 20483042 2263263 Peripheral blood mononuclear cells ( PBMC ) were analysed flow cytometrically either directly after isolation or after 24 hours of anti-CD3/anti-CD28 stimulation , to determine spontaneous and *induced* [STAT4] and STAT6 phosphorylation in CD4+ T cells . Positive_regulation STAT4 IL12B 20593019 2285921 However , despite inducing up-regulation of these activation markers and , hence , delivering positive signals , prostate tumor cells inhibited the *induced* [STAT4] phosphorylation in a cell-cell contact dependent but CD1d independent manner . Positive_regulation STAT4 IL12B 20876105 2331967 Whereas the phosphorylation of [STAT4] was normally *induced* by stimulation , STAT4 was not recruited to the Ifng gene regions in Nfkbiz ( -/- ) NK cells . Positive_regulation STAT4 IL12B 21555485 2440877 Constitutive expression of high levels of IL-12 receptor by iNKT cells enabled instant induced [STAT4] *activation* , demonstrating that among T cells , iNKT cells are uniquely equipped for immediate , cytokine-driven activation . Positive_regulation STAT4 IL12B 21813204 2495449 Exposure of splenocytes to AEBSF for 3h noticeably inhibited the induction of IFN? , IL-12 , and *induced* [STAT4ß] , mRNA expression of T-bet and IL-12Rß2 . Positive_regulation STAT4 IL12B 22311028 2586376 [STAT4] and STAT6 were *activated* by and IL-4 stimulation , which were important for the generation of Th1 and Th2 cells . Positive_regulation STAT4 IL12B 23064011 2689956 Investigation into the signaling mechanism suggested that phosphorylation of [STAT-4] in *response* to was sustained for a longer duration in aged CD4+ T cells as compared to CD4+ T cells from young subjects . Positive_regulation STAT4 IL12B 24958858 2947367 Interrogation of mechanism showed that testosterone regulates T-helper 1 (Th1) differentiation by inhibiting *induced* [Stat4] phosphorylation : in murine models , we determined that androgen receptor binds a conserved region within the phosphatase , Ptpn1 , and consequent up-regulation of Ptpn1 then inhibits IL-12 signaling in CD4 T cells . Positive_regulation STAT4 IL12B 7638186 317691 In this report we demonstrate that *induces* tyrosine phosphorylation of a recently identified STAT family member , [STAT4] , and show that STAT4 expression is regulated by T-cell activation . Positive_regulation STAT4 IL12B 7760829 308003 In contrast , IL-2 , IL-3 , and erythropoietin induce the tyrosine phosphorylation of Stat5 while uniquely *induces* the tyrosine phosphorylation of [Stat4] . Positive_regulation STAT4 IL12B 8683106 370253 In contrast to IL-2 and IFN-alpha , *induced* strong tyrosine phosphorylation of [STAT4] and variable weak phosphorylation of STAT3 . Positive_regulation STAT4 IL12B 8683106 370257 However , supershift analyses using the c-fos promoter sis-inducible element probe showed that *activated* [STAT4] , STAT1 alpha , and STAT3 , and induced complexes containing STAT4 only , STAT4 with STAT1 alpha , STAT3 with STAT1 alpha , or STAT1 alpha only in preactivated primary NK cells . Positive_regulation STAT4 IL12B 8906805 394387 The IL-12 nonresponsiveness of the Th2 clones was further evident by the total lack of *induced* phosphorylation of [STAT4] ( signal transducer and activator of transcription-4 ) , a transcription factor that is typically involved in IL-12 signaling . Positive_regulation STAT4 IL12B 8943379 399997 *Activation* of [STAT4] by and IFN-alpha : evidence for the involvement of ligand induced tyrosine and serine phosphorylation . Positive_regulation STAT4 IL12B 8943379 400002 In this study , we demonstrated that [STAT4] *activation* by is not unique ; Positive_regulation STAT4 IL12B 8943379 400004 Thus , STAT4 activation was not IL-12 specific , and and IFN-alpha *activated* [STAT4] through both tyrosine and serine phosphorylation . Positive_regulation STAT4 IL12B 9079804 420709 One feature of Th2 differentiation in mice is the loss of *induced* Jak2 and [Stat4] activation , which is accompanied by the inability to produce IFN-gamma in response to IL-12 . Positive_regulation STAT4 IL12B 9257839 448533 The pattern of IL-12 responsiveness correlated with expression of the IL-12R signaling subunit , IL-12R beta2 , and with *induced* [STAT4] phosphorylation . Positive_regulation STAT4 IL12B 9454765 484363 The *induced* tyrosine phosphorylation of STAT5 and STAT1 , but not [STAT4] , is augmented in T cells activated into Th1 cells with PHA + interferon-gamma (IFN-gamma) compared with T cells activated with PHA alone . Positive_regulation STAT4 IL12B 9531298 496804 In Th1 cells , *activated* both STAT6 and [STAT4] , and IL-4 activated STAT6 , but in both cases the Th1 phenotype remained . Positive_regulation STAT4 IL12B 9574535 502527 Moreover , we showed that this increase in IFN-gamma could be explained by the dual *activation* of STAT1 and [STAT4] by IL-15 and , respectively . Positive_regulation STAT4 IL12B 9715265 527777 We demonstrate that *induces* [STAT4] only in freshly isolated primary NK cells , but not in primary T cells , consistent with the lack of the IL-12 receptor in resting T cells . Positive_regulation STAT4 IL12B 9886399 584684 This activation of [STAT4] in response to IL-2 is not *due* to the autocrine production of or IFN-alpha . Positive_regulation STAT4 IL12RB2 11298330 801881 These reversed cells are further characterized by a marked chain expression and fully *restored* IL-12-inducible [STAT4] activation . Positive_regulation STAT4 IL12RB2 14559241 1153813 These results suggest that SOCS-3 , expressed at high levels in Th2 cells , *plays* an inhibitory role in [STAT4] mediated IL-12 signaling by binding to the STAT4 docking site in , thus raising a possibility that SOCS-3 may play a role in regulation of Th differentiation . Positive_regulation STAT4 IL13 10961885 726574 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL13 11894097 920692 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective induced [Stat4] *activation* . Positive_regulation STAT4 IL13 15087447 1258052 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL13 18988675 2034944 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL13 7638186 317649 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL15 10961885 726575 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL15 11894097 920693 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective *induced* [Stat4] activation . Positive_regulation STAT4 IL15 12759422 1091140 We also show that *activated* the binding of STAT1 , STAT3 , [STAT4] , and STAT5 to the regulatory sites of the IFN-gamma gene . Positive_regulation STAT4 IL15 15087447 1258053 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL15 18988675 2034945 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL15 7638186 317650 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL15 9574535 502528 Moreover , we showed that this increase in IFN-gamma could be explained by the dual *activation* of STAT1 and [STAT4] by and IL-12 , respectively . Positive_regulation STAT4 IL16 10961885 726576 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL16 11894097 920694 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective induced [Stat4] *activation* . Positive_regulation STAT4 IL16 15087447 1258054 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL16 18988675 2034946 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL16 7638186 317651 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL17D 14657353 1177306 signaling through TCCR/WSX-1 *induces* phosphorylation of Stat1 , Stat3 , [Stat4] , and Stat5 . Positive_regulation STAT4 IL18 10961885 726577 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL18 11207258 786871 IL-12 alone already induced the expression of IFN-gamma mRNA , but nuclear translocation of [STAT4] , the release of IFN-gamma protein , and the subsequent production of NO was strictly *dependent* on the simultaneous presence of . Positive_regulation STAT4 IL18 11894097 920695 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective *induced* [Stat4] activation . Positive_regulation STAT4 IL18 12165484 972833 Cutting edge : a murine , IL-12 independent pathway of IFN-gamma induction by gram negative bacteria based on [STAT4] *activation* by Type I IFN and signaling . Positive_regulation STAT4 IL18 15087447 1258055 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL18 18988675 2034947 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL18 7638186 317652 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL19 10961885 726578 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL19 11894097 920696 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective induced [Stat4] *activation* . Positive_regulation STAT4 IL19 15087447 1258056 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL19 18988675 2034948 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL19 7638186 317653 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL2 10961885 726579 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL2 11894097 920697 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective *induced* [Stat4] activation . Positive_regulation STAT4 IL2 14607923 1162114 We demonstrated that *activates* not only STAT3 , STAT5 , the phosphatidylinositol 3-kinase pathway , and extracellular signal regulated kinase-2 pathway , but also [STAT4] as in NK cells , and the p38 mitogen activated protein kinase pathway as in alphabeta T cells . Positive_regulation STAT4 IL2 14688310 1190440 Furthermore , the cytokine *potentiated* sustained [IL-12/STAT4] responses through up-regulation of IL-12R expression and synergized with IL-12 in driving Th1 cell development . Positive_regulation STAT4 IL2 15087447 1258057 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL2 17038663 1692798 and IL-18 attenuation of airway hyperresponsiveness *requires* [STAT4] , IFN-gamma , and natural killer cells . Positive_regulation STAT4 IL2 18456817 1926974 We demonstrated that *activates* not only STAT3 and -5 and the PI-3K and ERK-2 pathways as in all IL-2 responder cells but also [STAT4] as in NK cells and the p38 MAPK pathway as in alphabeta T cells . Positive_regulation STAT4 IL2 18988675 2034949 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL2 7638186 317654 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL2 7988557 282601 [STAT4] is not *activated* by . Positive_regulation STAT4 IL2 9886399 584675 *induces* [STAT4] activation in primary NK cells and NK cell lines , but not in T cells . Positive_regulation STAT4 IL2 9886399 584681 In this study , we show that in primary NK cells and NK cell lines , in addition to the activation of STAT1 and STAT5 , *induces* tyrosine phosphorylation of [STAT4] , a STAT previously reported to be activated only in response to IL-12 and IFN-alpha . Positive_regulation STAT4 IL2 9886399 584685 This activation of [STAT4] in *response* to is not due to the autocrine production of IL-12 or IFN-alpha . Positive_regulation STAT4 IL2 9886399 584689 Although the activation of [STAT4] in *response* to occurs in primary resting and activated NK cells , it does not occur in primary resting T cells or mitogen activated T cells . Positive_regulation STAT4 IL20 10961885 726580 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL20 11894097 920698 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective induced [Stat4] *activation* . Positive_regulation STAT4 IL20 15087447 1258058 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL20 18988675 2034950 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL20 7638186 317655 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL21 10961885 726581 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL21 11894097 920699 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective *induced* [Stat4] activation . Positive_regulation STAT4 IL21 12759422 1091148 Similarly , *induced* the binding of STAT1 , STAT3 , and [STAT4] to these elements . Positive_regulation STAT4 IL21 12759422 1091150 IL-15- and *induced* STAT1 and [STAT4] activation was verified by immunoprecipitation with anti-phosphotyrosine Abs followed by Western blotting with anti-STAT1 and anti-STAT4 Abs . IL-18 was not able to induce the binding of STATs to IFN-gamma gene regulatory sites . Positive_regulation STAT4 IL21 15087447 1258059 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL21 17548600 1752296 Here , we show that does not *require* [STAT4] to stimulate development of cytolytic activity . Positive_regulation STAT4 IL21 18988675 2034951 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL21 7638186 317656 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL22 10961885 726564 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL22 11894097 920682 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective *induced* [Stat4] activation . Positive_regulation STAT4 IL22 15087447 1258029 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL22 18988675 2034934 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL22 7638186 317639 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL23A 11114383 757805 nonetheless , *activates* [Stat4] in PHA blast T cells . Positive_regulation STAT4 IL23A 20415779 2246547 binding to an IL-23 receptor expressed on dendritic cells , macrophages and monocytes triggers the activation of Jak2 and Tyk2 , which in turn phosphorylates STAT1 , STAT3 , STAT4 and STAT5 as well as *induce* formation of [STAT3-STAT4] heterodimers . Positive_regulation STAT4 IL23R 20415779 2246548 IL-23 binding to an expressed on dendritic cells , macrophages and monocytes triggers the activation of Jak2 and Tyk2 , which in turn phosphorylates STAT1 , STAT3 , STAT4 and STAT5 as well as *induce* formation of [STAT3-STAT4] heterodimers . Positive_regulation STAT4 IL24 10961885 726562 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL24 11894097 920680 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective *induced* [Stat4] activation . Positive_regulation STAT4 IL24 15087447 1258027 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL24 18988675 2034932 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL24 7638186 317637 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL25 10961885 726563 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL25 11894097 920681 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective induced [Stat4] *activation* . Positive_regulation STAT4 IL25 15087447 1258028 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL25 18988675 2034933 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL25 7638186 317638 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL26 10961885 726568 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL26 11894097 920686 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective induced [Stat4] *activation* . Positive_regulation STAT4 IL26 15087447 1258033 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL26 18988675 2034938 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL26 7638186 317643 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL27 10961885 726569 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL27 11894097 920687 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective *induced* [Stat4] activation . Positive_regulation STAT4 IL27 15087447 1258034 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL27 18988675 2034939 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL27 7638186 317644 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL3 10961885 726582 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL3 11894097 920700 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective induced [Stat4] *activation* . Positive_regulation STAT4 IL3 15087447 1258060 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL3 18988675 2034952 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL3 7638186 317657 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL31 10961885 726570 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL31 11894097 920688 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective induced [Stat4] *activation* . Positive_regulation STAT4 IL31 15087447 1258035 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL31 18988675 2034940 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL31 7638186 317645 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL32 10961885 726567 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL32 11894097 920685 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective *induced* [Stat4] activation . Positive_regulation STAT4 IL32 15087447 1258032 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL32 18988675 2034937 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL32 7638186 317642 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL33 10961885 726566 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL33 11894097 920684 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective induced [Stat4] *activation* . Positive_regulation STAT4 IL33 15087447 1258031 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL33 18988675 2034936 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL33 7638186 317641 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL34 10961885 726571 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL34 11894097 920689 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective *induced* [Stat4] activation . Positive_regulation STAT4 IL34 15087447 1258036 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL34 18988675 2034941 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL34 7638186 317646 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL37 10961885 726565 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL37 11894097 920683 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective induced [Stat4] *activation* . Positive_regulation STAT4 IL37 15087447 1258030 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL37 18988675 2034935 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL37 7638186 317640 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL4 10961885 726583 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL4 11359632 765294 This process is initiated by stimulation with antigen and the cytokines IL-12 and IL-4 , respectively , and requires antigen induced transcription factors such as NFAT and cytokine induced transcription factors such as [STAT4] , induced by IL-12 , and STAT6 , *induced* by . Positive_regulation STAT4 IL4 11894097 920701 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective *induced* [Stat4] activation . Positive_regulation STAT4 IL4 15087447 1258061 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL4 16237058 1470736 Moreover , *induced* [Stat4] expression in PDCs through a Stat6 dependent mechanism , and only the Stat4 expressing PDCs produced IFN-gamma . Positive_regulation STAT4 IL4 18988675 2034953 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL4 20483042 2263264 Peripheral blood mononuclear cells ( PBMC ) were analysed flow cytometrically either directly after isolation or after 24 hours of anti-CD3/anti-CD28 stimulation , to determine spontaneous and *induced* [STAT4] and STAT6 phosphorylation in CD4+ T cells . Positive_regulation STAT4 IL4 21520044 2538549 LLL12 also inhibited STAT3 phosphorylation induced by interleukin-6 (IL-6) and interferon-a but not STAT1 , STAT2 , [STAT4] and STAT6 phosphorylation *induced* by interferon-a , interferon-? and indicating the selectivity of LLL12 for STAT3 . Positive_regulation STAT4 IL4 22311028 2586377 [STAT4] and STAT6 were *activated* by interleukin (IL)-12 and stimulation , which were important for the generation of Th1 and Th2 cells . Positive_regulation STAT4 IL4 7638186 317658 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL4 9531298 496805 In Th1 cells , IL-12 activated both STAT6 and [STAT4] , and *activated* STAT6 , but in both cases the Th1 phenotype remained . Positive_regulation STAT4 IL5 10961885 726584 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL5 11894097 920702 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective induced [Stat4] *activation* . Positive_regulation STAT4 IL5 15087447 1258062 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL5 18988675 2034954 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL5 7638186 317659 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL6 10961885 726585 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL6 11894097 920703 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective *induced* [Stat4] activation . Positive_regulation STAT4 IL6 15087447 1258063 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL6 18988675 2034955 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL6 21520044 2538550 LLL12 also inhibited STAT3 phosphorylation *induced* by and interferon-a but not STAT1 , STAT2 , [STAT4] and STAT6 phosphorylation induced by interferon-a , interferon-? and IL-4 indicating the selectivity of LLL12 for STAT3 . Positive_regulation STAT4 IL6 7638186 317660 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL7 10961885 726586 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL7 11894097 920704 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective *induced* [Stat4] activation . Positive_regulation STAT4 IL7 15087447 1258064 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL7 18988675 2034956 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL7 7638186 317661 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL8 10961885 726587 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL8 11894097 920705 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective *induced* [Stat4] activation . Positive_regulation STAT4 IL8 15087447 1258065 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL8 18988675 2034957 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL8 7638186 317662 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 IL9 10961885 726588 Importance of the MKK6/p38 pathway for *induced* [STAT4] serine phosphorylation and transcriptional activity . Positive_regulation STAT4 IL9 11894097 920706 Furthermore , Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells , attributed in part to defective *induced* [Stat4] activation . Positive_regulation STAT4 IL9 15087447 1258066 Interferon alpha but not 12 *activates* [STAT4] signaling in human vascular endothelial cells . Positive_regulation STAT4 IL9 18988675 2034958 Signal transducer and activation of transcription ( STAT ) 4beta , a shorter isoform of *induced* [STAT4] , is preferentially activated by estrogen . Positive_regulation STAT4 IL9 7638186 317663 12 *induces* tyrosine phosphorylation and activation of [STAT4] in human lymphocytes . Positive_regulation STAT4 JAK2 10229872 611260 Inhibition of either or Tyk-2 *leads* to a decrease in the IL-12 induced tyrosine phosphorylation of Stat3 , but not of [Stat4] , protein . Positive_regulation STAT4 JAK2 20415779 2246550 IL-23 binding to an IL-23 receptor expressed on dendritic cells , macrophages and monocytes triggers the activation of and Tyk2 , which in turn phosphorylates STAT1 , STAT3 , STAT4 and STAT5 as well as *induce* formation of [STAT3-STAT4] heterodimers . Positive_regulation STAT4 MAPK1 10820390 694513 The object of the present study was to explore the *role* of mitogen activated protein kinases (MAPK) Erk1 and and phosphatidylinositol 3-kinase (PI3K) in [STAT4] regulation . Positive_regulation STAT4 MAPK1 15817683 1432418 IFN-gamma production in response to IL-12 plus IL-18 did not require increased expression of [STAT4] but was *dependent* on the activity of p38 . Positive_regulation STAT4 MAPK10 15817683 1432419 IFN-gamma production in response to IL-12 plus IL-18 did not require increased expression of [STAT4] but was *dependent* on the activity of p38 . Positive_regulation STAT4 MAPK11 15817683 1432420 IFN-gamma production in response to IL-12 plus IL-18 did not require increased expression of [STAT4] but was *dependent* on the activity of p38 . Positive_regulation STAT4 MAPK12 15817683 1432421 IFN-gamma production in response to IL-12 plus IL-18 did not require increased expression of [STAT4] but was *dependent* on the activity of p38 . Positive_regulation STAT4 MAPK13 15817683 1432422 IFN-gamma production in response to IL-12 plus IL-18 did not require increased expression of [STAT4] but was *dependent* on the activity of p38 . Positive_regulation STAT4 MAPK14 15817683 1432423 IFN-gamma production in response to IL-12 plus IL-18 did not require increased expression of [STAT4] but was *dependent* on the activity of p38 . Positive_regulation STAT4 MAPK15 15817683 1432416 IFN-gamma production in response to IL-12 plus IL-18 did not require increased expression of [STAT4] but was *dependent* on the activity of p38 . Positive_regulation STAT4 MAPK3 10820390 694514 The object of the present study was to explore the *role* of mitogen activated protein kinases (MAPK) and Erk2 and phosphatidylinositol 3-kinase (PI3K) in [STAT4] regulation . Positive_regulation STAT4 MAPK3 15817683 1432424 IFN-gamma production in response to IL-12 plus IL-18 did not require increased expression of [STAT4] but was *dependent* on the activity of p38 . Positive_regulation STAT4 MAPK4 15817683 1432425 IFN-gamma production in response to IL-12 plus IL-18 did not require increased expression of [STAT4] but was *dependent* on the activity of p38 . Positive_regulation STAT4 MAPK6 15817683 1432426 IFN-gamma production in response to IL-12 plus IL-18 did not require increased expression of [STAT4] but was *dependent* on the activity of p38 . Positive_regulation STAT4 MAPK7 15817683 1432427 IFN-gamma production in response to IL-12 plus IL-18 did not require increased expression of [STAT4] but was *dependent* on the activity of p38 . Positive_regulation STAT4 MAPK8 15817683 1432428 IFN-gamma production in response to IL-12 plus IL-18 did not require increased expression of [STAT4] but was *dependent* on the activity of p38 . Positive_regulation STAT4 MAPK9 15817683 1432429 IFN-gamma production in response to IL-12 plus IL-18 did not require increased expression of [STAT4] but was *dependent* on the activity of p38 . Positive_regulation STAT4 NFKB1 17046972 1674729 is *required* for [STAT-4] expression during dendritic cell maturation . Positive_regulation STAT4 PI3 10820390 694515 The object of the present study was to explore the *role* of mitogen activated protein kinases (MAPK) Erk1 and Erk2 and in [STAT4] regulation . Positive_regulation STAT4 PLAU 10446176 636368 In this study , we demonstrate that [Stat4] and Stat2 , but not Stat3 , Stat5 , or Stat6 , are rapidly activated in *response* to . Positive_regulation STAT4 PTBP1 10861035 705121 Receptor engagement of as well as Con A blasts by IL-12 *resulted* in activation of Janus kinase 2 and Tyk2 kinases and Stat3 and [Stat4] transcription factors and the association of these proteins to IL-12Rbeta1 . Positive_regulation STAT4 PTBP2 10861035 705118 Receptor engagement of as well as Con A blasts by IL-12 *resulted* in activation of Janus kinase 2 and Tyk2 kinases and Stat3 and [Stat4] transcription factors and the association of these proteins to IL-12Rbeta1 . Positive_regulation STAT4 RELA 17046972 1674730 is *required* for [STAT-4] expression during dendritic cell maturation . Positive_regulation STAT4 SOCS3 16510856 1530539 These results indicate that a defective [STAT4] activation , likely *dependent* on elevated levels , is involved in the impaired IL-12 dependent T-cell functions with aging . Positive_regulation STAT4 STAT1 10644731 661366 Expression of murine Stat4 in the Stat1-deficient U3A and the Stat2-deficient U6A cell lines shows that IFN-alpha induced [Stat4] phosphorylation *requires* the presence of activated Stat2 but not . Positive_regulation STAT4 STAT2 10644731 661367 Expression of murine Stat4 in the Stat1-deficient U3A and the Stat2-deficient U6A cell lines shows that IFN-alpha induced [Stat4] phosphorylation *requires* the presence of activated but not Stat1 . Positive_regulation STAT4 STAT4 11389027 822018 Decreased levels of protein *lead* to decreased [STAT4] DNA binding activity and reduced proliferation and secretion of IFN-gamma . Positive_regulation STAT4 STAT6 11359632 765291 This process is initiated by stimulation with antigen and the cytokines IL-12 and IL-4 , respectively , and requires antigen induced transcription factors such as NFAT and cytokine induced transcription factors such as [STAT4] , *induced* by IL-12 , and , induced by IL-4 . Positive_regulation STAT4 TNF 18678606 1973298 Instead , and PGE2 *increased* Stat1 serine phosphorylation and [Stat4] tyrosine phosphorylation and activated expression of the NF-kappaB and Stat1 target gene IFN regulatory factor 1 (IRF1) , which contributes to IFN responses . Positive_regulation STAT4 TPO 7796811 313797 We demonstrated that *activates* the kinase JAK2 and a STAT5-like transcriptional factor but not STAT1 , STAT2 , STAT3 or [STAT4] , in a very rapid and transient manner . Positive_regulation STAT4 TYK2 10229872 611257 Inhibition of either Jak-2 or *leads* to a decrease in the IL-12 induced tyrosine phosphorylation of Stat3 , but not of [Stat4] , protein . Positive_regulation STAT4 TYK2 20415779 2246546 IL-23 binding to an IL-23 receptor expressed on dendritic cells , macrophages and monocytes triggers the activation of Jak2 and , which in turn phosphorylates STAT1 , STAT3 , STAT4 and STAT5 as well as *induce* formation of [STAT3-STAT4] heterodimers . Positive_regulation STAT5A CCND1 24737397 2943092 Mechanistically , aberrant PRL-3 expression promoted cell cycle progression and enhanced the antiapoptotic machinery of AML cells to drug cytotoxicity through downregulation of p21 and upregulation of and CDK2 and *activation* of [STAT5] and AKT . Positive_regulation STAT5A EPHB2 22205628 2558808 Compared with noncomplexed hPRL , complexed hPRL in whole milk showed similar activation of [STAT5] but markedly delayed *activation* of . Positive_regulation STAT5A MAP2K6 9406863 470466 The inhibitor did not *reduce* GH-stimulated nuclear translocation of [STAT5] . Positive_regulation STAT5A PLAU 10446176 636369 In this study , we demonstrate that Stat4 and Stat2 , but not Stat3 , [Stat5] , or Stat6 , are rapidly activated in *response* to . Positive_regulation STAT5A STAT4 12407017 1010089 Serine phosphorylation has also been found to occur in a number of STAT proteins , including Stat1 , Sat3 , Stat4 , Stat5a , Stat5b and Stat6 , and was shown to be important for maximal transcriptional activation *mediated* by Stat1 , Stat3 and , but not for [Stat5a] or Stat5b . Positive_regulation STAT5A STAT4 7760829 308004 In contrast , IL-2 , IL-3 , and erythropoietin *induce* the tyrosine phosphorylation of [Stat5] while IL-12 uniquely induces the tyrosine phosphorylation of . Positive_regulation STAT5A TNF 15086448 1234702 Staining of the ganglionic cells with an antibody against the transcription factor STAT5 revealed that *induced* a nuclear translocation of [STAT5] in non-neuronal cells . Positive_regulation STAT5A TNF 16985255 1692417 Initial characterization of the TNF-alpha and cycloheximide mediated degradation of STAT5 indicates that inhibition of the proteasome stabilizes both forms of [STAT5] in the *presence* of . Positive_regulation STAT5A TNF 16985255 1692418 In addition , the use of an NF-kappaB inhibitor results in the stabilization of [STAT5A] in the *presence* of and cycloheximide , indicating that the degradation of STAT5 proteins under these conditions may involve the NF-kappaB pathway . Positive_regulation STAT5A TNF 9862421 555907 downregulated insulin induced insulin receptor kinase activity and insulin *induced* activation of the transcription factor [STAT5] . Positive_regulation STAT5B STAT4 12407017 1010091 Serine phosphorylation has also been found to occur in a number of STAT proteins , including Stat1 , Sat3 , Stat4 , Stat5a , Stat5b and Stat6 , and was shown to be important for maximal transcriptional activation *mediated* by Stat1 , Stat3 and , but not for Stat5a or [Stat5b] . Positive_regulation STAT5B TNF 11801527 902543 *activates* [Jak1/Stat3-Stat5B] signaling through TNFR-1 in human B cells . Positive_regulation STAT6 CAPN8 21276008 2431184 PARP-1 deficiency blocks IL-5 expression through *dependent* degradation of [STAT-6] in a murine asthma model . Positive_regulation STAT6 CD14 24866794 2945613 Finally , we demonstrated that *regulates* [STAT6] activation , as Cd14 ( -/- ) mice had increased STAT6 activation in vivo , suggesting that lack of CD14 impacts the IL-4Ra-STAT6 pathway , altering macrophage polarization during parasite infection . Positive_regulation STAT6 EPHB2 17433443 1736798 In cytokine producing Jurkat T cells , we have found that IL-4 induces activation of Erk and Akt , and the IL-4 induced [STAT6] activity is *suppressed* by inhibitors of and PI3K . Positive_regulation STAT6 EPHB2 17433443 1736825 The Ras induced increase of both [STAT6] activity and IL-4 mRNA level was effectively *blocked* by a inhibitor , suggesting that Ras/Erk pathway positively regulates STAT6 activity and IL-4 transcription . Positive_regulation STAT6 MAP2K6 17433443 1736833 The Ras induced increase of both [STAT6] activity and IL-4 mRNA level was effectively *blocked* by a inhibitor , suggesting that Ras/Erk pathway positively regulates STAT6 activity and IL-4 transcription . Positive_regulation STAT6 PLAU 10446176 636370 In this study , we demonstrate that Stat4 and Stat2 , but not Stat3 , Stat5 , or [Stat6] , are rapidly activated in *response* to . Positive_regulation STAT6 TNF 14530343 1149244 We previously found that IL-4 and cooperate in the *activation* of [STAT6] and NF-kappaB , suggesting that these transcription factors are regulated by common intracellular signaling pathways . Positive_regulation STAT6 TNF 14733929 1199157 Western blotting analysis demonstrated that IFN-gamma downmodulated [STAT6] phosphorylation *induced* by IL-4 and . Positive_regulation STAT6 TNF 14733929 1199160 In SOCS-1 ( -/- ) MEF , IFN-gamma inhibited neither [STAT6] phosphorylation nor eotaxin production *induced* by IL-4 and . Positive_regulation STAT6 TNF 17878383 1797026 Activation of NF-kappaB , [STAT6] , and STAT1 was *induced* in eosinophils by , IL-4 , and IFN-gamma , respectively . Positive_regulation STC1 SLC1A6 16418298 1514583 Uptake by PCs can be monitored by recording the [synaptic transport current (STC)] *mediated* by the PC-specific transporter ( EAAT4 ) . Positive_regulation STEAP4 IL1B 19289123 2051563 [TIARP/STAMP2] mRNA synthesis was significantly *stimulated* by in a dose- and time dependent fashion in 3T3-L1 adipocytes . Positive_regulation STEAP4 IL1B 19289123 2051565 Signaling studies suggested that janus kinase 2 , nuclear factor kappaB , and p44/42 mitogen activated protein kinase are involved in *induced* [TIARP/STAMP2] mRNA expression . Positive_regulation STEAP4 IL1B 19289123 2051593 Moreover , both [TIARP/STAMP2] mRNA synthesis and protein expression were *induced* by in fully differentiated human mesenchymal stem cell derived adipocytes ( hMSC-Ad ) . Positive_regulation STEAP4 TNF 18430367 1900140 The [STEAP4] expression was *induced* by in a dose dependent manner in human adipose tissue . Positive_regulation STEAP4 TNF 18430367 1900142 [STEAP4] localized to the plasma membrane of adipocytes , and the STEAP4 expression was *induced* by in adipose tissue . Positive_regulation STIM1 CAPN8 21876174 2478015 [STIM1] *involves* the activation of Ca ( 2+ ) -regulated protease , as well as Ca ( 2+ ) -regulated cytoplasmic kinase Pyk2 , which regulate the focal-adhesion dynamics of migratory cervical cancer cells . Positive_regulation STIM1 EPHB2 22298426 2575831 The netrin-2 mediated NFATc3 activation was coincident with robust interactions between Cdo and Stim1 in myoblasts and the *mediated* [Stim1] phosphorylation at serine 575 . Positive_regulation STIM1 FAS 20643097 2304804 Here we show that activation of receptor in T-cells *results* in caspase dependent decrease of cellular [STIM1] and Orai1 protein content . Positive_regulation STIM1 TNF 22241747 2629507 increased SOCE following sarcoplasmic reticulum Ca ( 2+ ) depletion , and *increased* whole-cell and caveolar Orai1 ( but only intracellular [STIM1] ) . Positive_regulation STK10 ANGPT1 15501241 1327026 VEGF treatment of cultured smooth muscle cells (SMC) upregulated Tie2 and allowed for *mediated* phosphorylation of Tie2 and the AKT [serine-threonine kinase] . Positive_regulation STK10 GPR115 20625315 2327879 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK10 GPR132 20625315 2327868 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK10 GPR87 20625315 2327948 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK10 IGFBP1 10792618 689348 The IGFBP-5 stimulatory pathway is mediated by the [serine/threonine kinase] IGFBP-5 receptor , which is *activated* by the carboxy-terminal peptide . Positive_regulation STK10 MAP2K6 10924861 718447 Genistein , a tyrosine kinase inhibitor , H7 , a [serine/threonine kinase] *inhibitor* , and PD 98059 , a inhibitor , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation STK10 TNF 11287630 800286 inhibited insulin promoted tyrosine phosphorylation of IRS-1 and *activated* the Akt/protein kinase B [serine-threonine kinase] , a downstream target for phosphatidylinositol 3-kinase ( PI 3-kinase ) . Positive_regulation STK10 TNF 1319489 189593 Interleukin 1 and *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK11 ANGPT1 15501241 1327027 VEGF treatment of cultured smooth muscle cells (SMC) upregulated Tie2 and allowed for *mediated* phosphorylation of Tie2 and the AKT [serine-threonine kinase] . Positive_regulation STK11 GPR115 20625315 2327972 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK11 GPR132 20625315 2327961 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK11 GPR87 20625315 2328041 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK11 IGFBP1 10792618 689355 The IGFBP-5 stimulatory pathway is mediated by the [serine/threonine kinase] IGFBP-5 receptor , which is *activated* by the carboxy-terminal peptide . Positive_regulation STK11 MAP2K6 10924861 718454 Genistein , a tyrosine kinase inhibitor , H7 , a [serine/threonine kinase] *inhibitor* , and PD 98059 , a inhibitor , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation STK11 TNF 11287630 800287 inhibited insulin promoted tyrosine phosphorylation of IRS-1 and *activated* the Akt/protein kinase B [serine-threonine kinase] , a downstream target for phosphatidylinositol 3-kinase ( PI 3-kinase ) . Positive_regulation STK11 TNF 1319489 189621 Interleukin 1 and *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK16 ANGPT1 15501241 1327028 VEGF treatment of cultured smooth muscle cells (SMC) upregulated Tie2 and allowed for *mediated* phosphorylation of Tie2 and the AKT [serine-threonine kinase] . Positive_regulation STK16 GPR115 20625315 2328065 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK16 GPR132 20625315 2328054 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK16 GPR87 20625315 2328134 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK16 IGFBP1 10792618 689362 The IGFBP-5 stimulatory pathway is mediated by the [serine/threonine kinase] IGFBP-5 receptor , which is *activated* by the carboxy-terminal peptide . Positive_regulation STK16 MAP2K6 10924861 718461 Genistein , a tyrosine kinase inhibitor , H7 , a [serine/threonine kinase] *inhibitor* , and PD 98059 , a inhibitor , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation STK16 TNF 11287630 800288 inhibited insulin promoted tyrosine phosphorylation of IRS-1 and *activated* the Akt/protein kinase B [serine-threonine kinase] , a downstream target for phosphatidylinositol 3-kinase ( PI 3-kinase ) . Positive_regulation STK16 TNF 1319489 189649 Interleukin 1 and *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK19 ANGPT1 15501241 1327029 VEGF treatment of cultured smooth muscle cells (SMC) upregulated Tie2 and allowed for *mediated* phosphorylation of Tie2 and the AKT [serine-threonine kinase] . Positive_regulation STK19 GPR115 20625315 2328158 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK19 GPR132 20625315 2328147 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK19 GPR87 20625315 2328227 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK19 IGFBP1 10792618 689369 The IGFBP-5 stimulatory pathway is mediated by the [serine/threonine kinase] IGFBP-5 receptor , which is *activated* by the carboxy-terminal peptide . Positive_regulation STK19 MAP2K6 10924861 718468 Genistein , a tyrosine kinase inhibitor , H7 , a [serine/threonine kinase] *inhibitor* , and PD 98059 , a inhibitor , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation STK19 TNF 11287630 800289 inhibited insulin promoted tyrosine phosphorylation of IRS-1 and *activated* the Akt/protein kinase B [serine-threonine kinase] , a downstream target for phosphatidylinositol 3-kinase ( PI 3-kinase ) . Positive_regulation STK19 TNF 1319489 189677 Interleukin 1 and *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK24 ANGPT1 15501241 1327030 VEGF treatment of cultured smooth muscle cells (SMC) upregulated Tie2 and allowed for *mediated* phosphorylation of Tie2 and the AKT [serine-threonine kinase] . Positive_regulation STK24 GPR115 20625315 2328251 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK24 GPR132 20625315 2328240 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK24 GPR87 20625315 2328320 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK24 IGFBP1 10792618 689376 The IGFBP-5 stimulatory pathway is mediated by the [serine/threonine kinase] IGFBP-5 receptor , which is *activated* by the carboxy-terminal peptide . Positive_regulation STK24 MAP2K6 10924861 718475 Genistein , a tyrosine kinase inhibitor , H7 , a [serine/threonine kinase] *inhibitor* , and PD 98059 , a inhibitor , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation STK24 TNF 11287630 800290 inhibited insulin promoted tyrosine phosphorylation of IRS-1 and *activated* the Akt/protein kinase B [serine-threonine kinase] , a downstream target for phosphatidylinositol 3-kinase ( PI 3-kinase ) . Positive_regulation STK24 TNF 1319489 189705 Interleukin 1 and *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK25 ANGPT1 15501241 1327031 VEGF treatment of cultured smooth muscle cells (SMC) upregulated Tie2 and allowed for *mediated* phosphorylation of Tie2 and the AKT [serine-threonine kinase] . Positive_regulation STK25 GPR115 20625315 2328344 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK25 GPR132 20625315 2328333 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK25 GPR87 20625315 2328413 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK25 IGFBP1 10792618 689383 The IGFBP-5 stimulatory pathway is mediated by the [serine/threonine kinase] IGFBP-5 receptor , which is *activated* by the carboxy-terminal peptide . Positive_regulation STK25 MAP2K6 10924861 718482 Genistein , a tyrosine kinase inhibitor , H7 , a [serine/threonine kinase] *inhibitor* , and PD 98059 , a inhibitor , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation STK25 TNF 11287630 800291 inhibited insulin promoted tyrosine phosphorylation of IRS-1 and *activated* the Akt/protein kinase B [serine-threonine kinase] , a downstream target for phosphatidylinositol 3-kinase ( PI 3-kinase ) . Positive_regulation STK25 TNF 1319489 189733 Interleukin 1 and *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK3 ANGPT1 15501241 1327032 VEGF treatment of cultured smooth muscle cells (SMC) upregulated Tie2 and allowed for *mediated* phosphorylation of Tie2 and the AKT [serine-threonine kinase] . Positive_regulation STK3 GPR115 20625315 2328437 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK3 GPR132 20625315 2328426 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK3 GPR87 20625315 2328506 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK3 IGFBP1 10792618 689390 The IGFBP-5 stimulatory pathway is mediated by the [serine/threonine kinase] IGFBP-5 receptor , which is *activated* by the carboxy-terminal peptide . Positive_regulation STK3 MAP2K6 10924861 718489 Genistein , a tyrosine kinase inhibitor , H7 , a [serine/threonine kinase] *inhibitor* , and PD 98059 , a inhibitor , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation STK3 TNF 11287630 800292 inhibited insulin promoted tyrosine phosphorylation of IRS-1 and *activated* the Akt/protein kinase B [serine-threonine kinase] , a downstream target for phosphatidylinositol 3-kinase ( PI 3-kinase ) . Positive_regulation STK3 TNF 1319489 189761 Interleukin 1 and *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK31 ANGPT1 15501241 1327033 VEGF treatment of cultured smooth muscle cells (SMC) upregulated Tie2 and allowed for *mediated* phosphorylation of Tie2 and the AKT [serine-threonine kinase] . Positive_regulation STK31 GPR115 20625315 2328530 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK31 GPR132 20625315 2328519 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK31 GPR87 20625315 2328599 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK31 IGFBP1 10792618 689397 The IGFBP-5 stimulatory pathway is mediated by the [serine/threonine kinase] IGFBP-5 receptor , which is *activated* by the carboxy-terminal peptide . Positive_regulation STK31 MAP2K6 10924861 718496 Genistein , a tyrosine kinase inhibitor , H7 , a [serine/threonine kinase] *inhibitor* , and PD 98059 , a inhibitor , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation STK31 TNF 11287630 800293 inhibited insulin promoted tyrosine phosphorylation of IRS-1 and *activated* the Akt/protein kinase B [serine-threonine kinase] , a downstream target for phosphatidylinositol 3-kinase ( PI 3-kinase ) . Positive_regulation STK31 TNF 1319489 189789 Interleukin 1 and *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK33 ANGPT1 15501241 1327036 VEGF treatment of cultured smooth muscle cells (SMC) upregulated Tie2 and allowed for *mediated* phosphorylation of Tie2 and the AKT [serine-threonine kinase] . Positive_regulation STK33 GPR115 20625315 2328716 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK33 GPR132 20625315 2328705 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK33 GPR87 20625315 2328785 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK33 IGFBP1 10792618 689411 The IGFBP-5 stimulatory pathway is mediated by the [serine/threonine kinase] IGFBP-5 receptor , which is *activated* by the carboxy-terminal peptide . Positive_regulation STK33 MAP2K6 10924861 718510 Genistein , a tyrosine kinase inhibitor , H7 , a [serine/threonine kinase] *inhibitor* , and PD 98059 , a inhibitor , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation STK33 TNF 11287630 800295 inhibited insulin promoted tyrosine phosphorylation of IRS-1 and *activated* the Akt/protein kinase B [serine-threonine kinase] , a downstream target for phosphatidylinositol 3-kinase ( PI 3-kinase ) . Positive_regulation STK33 TNF 1319489 189845 Interleukin 1 and *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK35 ANGPT1 15501241 1327037 VEGF treatment of cultured smooth muscle cells (SMC) upregulated Tie2 and allowed for *mediated* phosphorylation of Tie2 and the AKT [serine-threonine kinase] . Positive_regulation STK35 GPR115 20625315 2328809 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK35 GPR132 20625315 2328798 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK35 GPR87 20625315 2328878 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK35 IGFBP1 10792618 689418 The IGFBP-5 stimulatory pathway is mediated by the [serine/threonine kinase] IGFBP-5 receptor , which is *activated* by the carboxy-terminal peptide . Positive_regulation STK35 MAP2K6 10924861 718517 Genistein , a tyrosine kinase inhibitor , H7 , a [serine/threonine kinase] *inhibitor* , and PD 98059 , a inhibitor , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation STK35 TNF 11287630 800296 inhibited insulin promoted tyrosine phosphorylation of IRS-1 and *activated* the Akt/protein kinase B [serine-threonine kinase] , a downstream target for phosphatidylinositol 3-kinase ( PI 3-kinase ) . Positive_regulation STK35 TNF 1319489 189873 Interleukin 1 and *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK36 ANGPT1 15501241 1327038 VEGF treatment of cultured smooth muscle cells (SMC) upregulated Tie2 and allowed for *mediated* phosphorylation of Tie2 and the AKT [serine-threonine kinase] . Positive_regulation STK36 GPR115 20625315 2328902 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK36 GPR132 20625315 2328891 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK36 GPR87 20625315 2328971 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK36 IGFBP1 10792618 689425 The IGFBP-5 stimulatory pathway is mediated by the [serine/threonine kinase] IGFBP-5 receptor , which is *activated* by the carboxy-terminal peptide . Positive_regulation STK36 MAP2K6 10924861 718524 Genistein , a tyrosine kinase inhibitor , H7 , a [serine/threonine kinase] *inhibitor* , and PD 98059 , a inhibitor , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation STK36 TNF 11287630 800297 inhibited insulin promoted tyrosine phosphorylation of IRS-1 and *activated* the Akt/protein kinase B [serine-threonine kinase] , a downstream target for phosphatidylinositol 3-kinase ( PI 3-kinase ) . Positive_regulation STK36 TNF 1319489 189901 Interleukin 1 and *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK38 ANGPT1 15501241 1327040 VEGF treatment of cultured smooth muscle cells (SMC) upregulated Tie2 and allowed for *mediated* phosphorylation of Tie2 and the AKT [serine-threonine kinase] . Positive_regulation STK38 GPR115 20625315 2329088 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK38 GPR132 20625315 2329077 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK38 GPR87 20625315 2329157 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK38 IGFBP1 10792618 689439 The IGFBP-5 stimulatory pathway is mediated by the [serine/threonine kinase] IGFBP-5 receptor , which is *activated* by the carboxy-terminal peptide . Positive_regulation STK38 MAP2K6 10924861 718538 Genistein , a tyrosine kinase inhibitor , H7 , a [serine/threonine kinase] *inhibitor* , and PD 98059 , a inhibitor , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation STK38 TNF 11287630 800299 inhibited insulin promoted tyrosine phosphorylation of IRS-1 and *activated* the Akt/protein kinase B [serine-threonine kinase] , a downstream target for phosphatidylinositol 3-kinase ( PI 3-kinase ) . Positive_regulation STK38 TNF 1319489 189957 Interleukin 1 and *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 ABL1 10637231 660273 Surprisingly , elevated levels of c-Jun activated nuclear , *resulting* in activation of the JNK [serine/threonine kinase] . Positive_regulation STK39 AKT1 17504983 1740064 It is attempted to know how Hsp27 endues cell with cisplatin resistance by interfering with upstream of both apoptosis signal regulating kinase 1 ( ASK1 ) /p38 mitogen activated protein kinase activated apoptotic signaling and [serine/threonine kinase] *dependent* survival signaling . Positive_regulation STK39 AKT1 9478990 487122 Furthermore , we show that deactivation of glycogen synthase kinase 3 and *activation* of rapamycin-sensitive [serine/threonine kinase] by in L6 myotubes might be involved in the enhancement of glycogen synthesis and protein synthesis , respectively . Positive_regulation STK39 AKT2 17504983 1740065 It is attempted to know how Hsp27 endues cell with cisplatin resistance by interfering with upstream of both apoptosis signal regulating kinase 1 ( ASK1 ) /p38 mitogen activated protein kinase activated apoptotic signaling and [serine/threonine kinase] *dependent* survival signaling . Positive_regulation STK39 AKT3 17504983 1740066 It is attempted to know how Hsp27 endues cell with cisplatin resistance by interfering with upstream of both apoptosis signal regulating kinase 1 ( ASK1 ) /p38 mitogen activated protein kinase activated apoptotic signaling and [serine/threonine kinase] *dependent* survival signaling . Positive_regulation STK39 ANGPT1 15501241 1327039 VEGF treatment of cultured smooth muscle cells (SMC) upregulated Tie2 and allowed for *mediated* phosphorylation of Tie2 and the AKT [serine-threonine kinase] . Positive_regulation STK39 BMP2 12084724 976334 Requirement of *induced* phosphatidylinositol 3-kinase and Akt [serine/threonine kinase] in osteoblast differentiation and Smad dependent BMP-2 gene transcription . Positive_regulation STK39 BMP2 12084724 976405 *stimulated* Akt [serine/threonine kinase] activity in a PI 3-kinase dependent manner in osteoblast precursor cells . Positive_regulation STK39 CA2 15010850 1217961 Death associated protein kinase (DAPK) is a *dependent* [serine/threonine kinase] that has been implicated as a positive mediator of apoptosis . Positive_regulation STK39 CA2 15151256 1249900 Death associated protein kinase ( DAP kinase ) is a *dependent* [serine/threonine kinase] implicated as a positive apoptosis mediator . Positive_regulation STK39 CA2 15583830 1355982 Death associated protein kinase (DAPK) is a *dependent* [serine/threonine kinase] that is thought to mediate apoptosis . Positive_regulation STK39 CA2 16596273 1544839 Death associated protein kinase (DAPK) is a *dependent* [serine/threonine kinase] that is thought to mediate apoptosis . Positive_regulation STK39 CALM3 10561695 566874 Death associated protein kinase ( DAP-kinase ) is Ca ( 2+ ) *dependent* [serine/threonine kinase] that contains ankyrin repeats and the death domain . Positive_regulation STK39 CALM3 11313923 805867 Death associated protein (DAP)-kinase is a 16 kDa *dependent* [serine/threonine kinase] that carries a death domain at its C-terminus . Positive_regulation STK39 CALM3 12370243 995610 Death associated protein kinase ( DAP-kinase ) is a *dependent* [serine/threonine kinase] , and participates in various apoptosis systems . Positive_regulation STK39 CALM3 15010850 1217962 Death associated protein kinase (DAPK) is a *dependent* [serine/threonine kinase] that has been implicated as a positive mediator of apoptosis . Positive_regulation STK39 CALM3 15151256 1249901 Death associated protein kinase ( DAP kinase ) is a *dependent* [serine/threonine kinase] implicated as a positive apoptosis mediator . Positive_regulation STK39 CALM3 15213270 1262544 Death associated protein kinase (DAPK) is a *dependent* [serine/threonine kinase] localized to renal tubular epithelial cells . Positive_regulation STK39 CALM3 15583830 1355983 Death associated protein kinase (DAPK) is a *dependent* [serine/threonine kinase] that is thought to mediate apoptosis . Positive_regulation STK39 CALM3 16077944 1442465 Death associated protein kinase (DAPK) is a Ca ( 2+ ) *dependent* [serine/threonine kinase] that is thought to mediate apoptosis . Positive_regulation STK39 CALM3 16448786 1528000 Myosin light chain kinase 2 , skeletal muscle ( MYLK2 ) encodes a *dependent* [serine/threonine kinase] . Positive_regulation STK39 CALM3 16596273 1544840 Death associated protein kinase (DAPK) is a *dependent* [serine/threonine kinase] that is thought to mediate apoptosis . Positive_regulation STK39 CALM3 20479242 2269552 We have identified a mechanism for FFR involving heart rate dependent phosphorylation of the major cardiac sarcoplasmic reticulum calcium release channel/ryanodine receptor ( RyR2 ) , at Ser2814 , by *dependent* [serine/threonine kinase-delta] ( CaMKIIdelta ) . Positive_regulation STK39 CALM3 21235400 2425470 The resulting nitric oxide ( NO ) enhances the function of the glutamate N-methyl-d-aspartate receptor ( NMDAR ) /calcium and *dependent* [serine/threonine kinase] ( CaMKII ) , which subsequently diminishes MOR signaling strength . Positive_regulation STK39 CALM3 23173822 2729793 Levels of multiple glutamate receptor subunits , *dependent* protein kinase II ( CaMKII ) , a highly abundant [serine/threonine kinase] , and spinophilin , a F-actin and protein phosphatase 1 (PP1) binding protein , were significantly lower in striatal extracts , as well as in synaptic and/or extrasynaptic fractions , compared with similar hippocampal extracts/fractions . Positive_regulation STK39 CALM3 24005312 2836738 Neurexin-deficient neurons exhibited a decrease in the levels of the PDZ-domain protein CASK ( a *activated* [serine/threonine kinase] ) , which binds to neurexins , and mutation of the PDZ-domain binding sequence of neurexin-3ß blocked its transport to the neuronal surface and impaired heterologous synapse formation . Positive_regulation STK39 CALM3 7828849 293414 The second is transcribed into a single 6.3-kb mRNA and codes for a unique 160-kD *dependent* [serine/threonine kinase] ( DAP kinase ) that carries eight ankyrin repeats . Positive_regulation STK39 CAV1 9374534 465195 binding negatively *regulates* tyrosine and [serine/threonine kinase] activities . Positive_regulation STK39 CAV2 9374534 465196 binding negatively *regulates* tyrosine and [serine/threonine kinase] activities . Positive_regulation STK39 CAV3 9374534 465197 binding negatively *regulates* tyrosine and [serine/threonine kinase] activities . Positive_regulation STK39 CD28 14707136 1219213 Both and its relative , inducible costimulator (ICOS) , have a binding motif for phosphatidylinositol 3-kinase (PI3K) in their cytoplasmic tail , and the binding of PI3K *leads* to activation of a [serine/threonine kinase] , Akt . Positive_regulation STK39 CD28 9337876 458279 This study therefore demonstrates that ( 1 ) a *activated* [serine/threonine kinase] distinct from both PKC and PI 3-kinase mediates ligation stimulated CD28 phosphorylation , and ( 2 ) the PMA stimulated down-regulation of the coupling of CD28 to PI 3-kinase is not due to PMA stimulated phosphorylation of CD28 . Positive_regulation STK39 CD44 12145287 991777 Furthermore , we have found that the binding of HA to in MDA-MB-231 cells *stimulates* TGF-betaRI [serine/threonine kinase] activity which , in turn , increases Smad2/Smad3 phosphorylation and parathyroid hormone related protein ( PTH-rP ) production ( well known downstream effector functions of TGF-beta signaling ) . Positive_regulation STK39 CDC42 9755165 535664 This [serine/threonine kinase] is *activated* by GTP bound Rac1 or . Positive_regulation STK39 CDKN1A 11278436 810974 ACK1 interacts with the adaptor Nck via SH3 interactions but does not form a trimeric complex with *activated* [serine/threonine kinase] , which also binds Nck . Positive_regulation STK39 CDKN1A 19720142 2145303 The signalling pathways involving the small Rho GTPase , Rac and its downstream effector the *activated* [serine/threonine kinase] ( PAK ) had recently emerged as pleiotropic modulators in these processes . Positive_regulation STK39 CDKN1A 7592896 334498 Identification and molecular cloning of a *activated* [serine/threonine kinase] that is rapidly activated by thrombin in platelets . Positive_regulation STK39 CSK 10951585 723824 Such co-expression is consistent with a *role* for Hydra in regulation of [STK] activity . Positive_regulation STK39 CSK 10951585 723869 Phosphotyrosine immunoblot analysis confirmed that expression of *resulted* in suppression of [STK] kinase activity . Positive_regulation STK39 CTS1 16276348 1539315 The putative [serine threonine kinase] , PCTAIRE3 , and the quinone oxireductase , PIG3 , were strongly *induced* by compared with wild-type p53 . Positive_regulation STK39 DDT 19526567 2098623 In particulate fractions , total [serine/threonine kinase] activity was *increased* by 10 microM HC and o-p ' ( 59 % and 82 % , respectively ) . Positive_regulation STK39 EGF 1851758 159008 These results suggest that chimeric receptor activation *stimulates* at least one [serine/threonine kinase] , which in turn phosphorylates the kinase-deficient EGF receptor . Positive_regulation STK39 EGF 2142154 135762 Several separable *stimulated* [serine/threonine kinase] activities were characterized in the preceding paper ( Ahn , N. G. , Weiel , J. E. , Chan , C. P. , and Krebs , E.G. ( 1990 ) J. Biol. Chem. 265 , 11487-11494 ) . Positive_regulation STK39 EGF 22978663 2745041 Inhibition of AR also prevented the *induced* phosphorylation of phosphatidylinositol 3-kinase (PI3K) , [serine/threonine kinase] ( AKT ) , c-Jun , c-Fos , PTEN , and FOXO3a , and deoxyribonucleic acid ( DNA ) -binding activity of AP-1 . Positive_regulation STK39 EGF 3015918 61038 It has been suggested that could indirectly *activate* a [protein-serine/threonine kinase] , protein kinase C , that can phosphorylate the EGF receptor at threonine 654 . Positive_regulation STK39 EPX 7527668 280864 In these cells , also *induced* the expression of a [serine/threonine kinase] , Pim-1 . Positive_regulation STK39 FADD 11034606 740795 FIST/HIPK3 : a Fas/FADD interacting [serine/threonine kinase] that *induces* phosphorylation and inhibits fas mediated Jun NH ( 2 ) -terminal kinase activation . Positive_regulation STK39 GAS6 9973250 595857 *stimulated* the extracellular signal regulated kinase , ERK , and the [serine-threonine kinase] , Akt , a downstream component of the phosphoinositide 3-kinase (PI3-K) pathway . Positive_regulation STK39 GCHFR 15033170 1223334 Cyclin dependent kinase 5 (Cdk5) is a [serine-threonine kinase] that is *activated* by the binding of or p39 regulatory protein . Positive_regulation STK39 GP2 11483734 844571 The envelope of friend spleen focus forming virus covalently interacts with and constitutively *activates* a truncated form of the receptor tyrosine kinase [Stk] . Positive_regulation STK39 GP5 11483734 844572 The envelope of friend spleen focus forming virus covalently interacts with and constitutively *activates* a truncated form of the receptor tyrosine kinase [Stk] . Positive_regulation STK39 GP6 11483734 844570 The envelope of friend spleen focus forming virus covalently interacts with and constitutively *activates* a truncated form of the receptor tyrosine kinase [Stk] . Positive_regulation STK39 GP9 11483734 844573 The envelope of friend spleen focus forming virus covalently interacts with and constitutively *activates* a truncated form of the receptor tyrosine kinase [Stk] . Positive_regulation STK39 GPR1 20625315 2329025 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR101 20625315 2328981 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR107 20625315 2328986 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR108 20625315 2328985 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR110 20625315 2328991 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR111 20625315 2328992 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR112 20625315 2328993 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR113 20625315 2328990 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR114 20625315 2328994 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR115 20625315 2328995 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR116 20625315 2328996 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR119 20625315 2328997 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR12 20625315 2329026 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR123 20625315 2328978 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR124 20625315 2328987 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR125 20625315 2328979 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR126 20625315 2328980 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR128 20625315 2328998 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR132 20625315 2328984 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR133 20625315 2328999 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR135 20625315 2329000 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR137 20625315 2329018 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR139 20625315 2329001 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR141 20625315 2329002 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR142 20625315 2329003 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR143 20625315 2329004 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR144 20625315 2328989 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR146 20625315 2329006 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR148 20625315 2329010 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR149 20625315 2329012 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR15 20625315 2329027 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR150 20625315 2329013 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR151 20625315 2329011 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR152 20625315 2329009 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR153 20625315 2329008 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR155 20625315 2329007 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR156 20625315 2329005 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR157 20625315 2329014 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR158 20625315 2329015 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR160 20625315 2329016 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR161 20625315 2329017 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR162 20625315 2328982 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR17 20625315 2329028 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR171 20625315 2329020 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR173 20625315 2328988 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR174 20625315 2329021 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR176 20625315 2329024 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR179 20625315 2329023 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR18 20625315 2329029 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR180 20625315 2329019 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR182 20625315 2328976 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR183 20625315 2329022 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR19 20625315 2329030 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR20 20625315 2329031 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR21 20625315 2329032 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR22 20625315 2329033 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR25 20625315 2329034 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR26 20625315 2329035 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR27 20625315 2329036 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR3 20625315 2329037 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR31 20625315 2329038 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR32 20625315 2329039 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR33 20625315 2329040 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR34 20625315 2329041 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR35 20625315 2329042 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR36 20625315 2329043 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR37 20625315 2329044 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR39 20625315 2329045 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR4 20625315 2329046 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR42 20625315 2329047 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR45 20625315 2329048 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR50 20625315 2329049 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR52 20625315 2329050 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR55 20625315 2329051 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR56 20625315 2329052 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR6 20625315 2329053 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR61 20625315 2328973 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR62 20625315 2328974 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR63 20625315 2328975 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR64 20625315 2329054 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR65 20625315 2329055 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR68 20625315 2329056 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR75 20625315 2329058 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR78 20625315 2329059 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR79 20625315 2329060 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR82 20625315 2329061 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR83 20625315 2329057 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR84 20625315 2329062 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR85 20625315 2329063 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR87 20625315 2329064 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR88 20625315 2329065 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR97 20625315 2328977 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 GPR98 20625315 2328983 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK39 HRG 18283314 1885311 The p21 activated [serine/threonine kinase] 1 ( PAK1 ) , which plays an important role in breast cancer progression and resistance to the anti-oestrogen tamoxifen , is also *activated* by . Positive_regulation STK39 HSP90AA1 15935620 1451987 Akt ( PKB ) is an *dependent* [serine-threonine kinase] that plays critical roles in the regulation of muscle cell physiology , including roles in the regulation of muscle differentiation and anti-apoptotic responses that modulate cell survival . Positive_regulation STK39 ICOS 14707136 1219214 Both CD28 and its relative , , have a binding motif for phosphatidylinositol 3-kinase (PI3K) in their cytoplasmic tail , and the binding of PI3K *leads* to activation of a [serine/threonine kinase] , Akt . Positive_regulation STK39 IGFBP1 10792618 689432 The IGFBP-5 stimulatory pathway is mediated by the [serine/threonine kinase] IGFBP-5 receptor , which is *activated* by the carboxy-terminal peptide . Positive_regulation STK39 IGFBP2 10792618 689433 The IGFBP-5 stimulatory pathway is mediated by the [serine/threonine kinase] IGFBP-5 receptor , which is *activated* by the carboxy-terminal peptide . Positive_regulation STK39 IGFBP3 10792618 689434 The IGFBP-5 stimulatory pathway is mediated by the [serine/threonine kinase] IGFBP-5 receptor , which is *activated* by the carboxy-terminal peptide . Positive_regulation STK39 IGFBP4 10792618 689435 The IGFBP-5 stimulatory pathway is mediated by the [serine/threonine kinase] IGFBP-5 receptor , which is *activated* by the carboxy-terminal peptide . Positive_regulation STK39 IGFBP5 10792618 689436 The IGFBP-5 stimulatory pathway is mediated by the [serine/threonine kinase] IGFBP-5 receptor , which is *activated* by the carboxy-terminal peptide . Positive_regulation STK39 IGFBP6 10792618 689437 The IGFBP-5 stimulatory pathway is mediated by the [serine/threonine kinase] IGFBP-5 receptor , which is *activated* by the carboxy-terminal peptide . Positive_regulation STK39 IGFBP7 10792618 689438 The IGFBP-5 stimulatory pathway is mediated by the [serine/threonine kinase] IGFBP-5 receptor , which is *activated* by the carboxy-terminal peptide . Positive_regulation STK39 IL10 1319489 189939 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL11 1319489 189940 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL13 1319489 189941 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL15 1319489 189942 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL16 1319489 189943 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL18 1319489 189944 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL19 1319489 189945 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL1A 10609879 575415 Stimulation of the Interleukin-1 receptor type I (IL-1-RI) with *activates* an associated [serine/threonine kinase] , IRAK , which phosphorylates downstream targets , resulting in NFkappaB activation . Positive_regulation STK39 IL1R1 10609879 575416 Stimulation of the with IL-1 *activates* an associated [serine/threonine kinase] , IRAK , which phosphorylates downstream targets , resulting in NFkappaB activation . Positive_regulation STK39 IL2 1319489 189946 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL2 1639773 194679 Stimulation of the receptor *results* in phosphorylation and activation of cytosolic Raf-1 [serine/threonine kinase] . Positive_regulation STK39 IL2 19756449 2175930 Serum and glucocorticoid regulated kinase 1 ( Sgk1 ) is a [serine-threonine kinase] that is *activated* by serum , steroids , insulin , vasopressin , and at the transcriptional and post-translational levels . Positive_regulation STK39 IL20 1319489 189947 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL21 1319489 189948 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL22 1319489 189931 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL24 1319489 189928 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL25 1319489 189930 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL26 1319489 189935 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL27 1319489 189936 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL3 1319489 189949 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL31 1319489 189937 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL32 1319489 189934 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL33 1319489 189933 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL34 1319489 189938 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL37 1319489 189932 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL4 1319489 189950 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL5 1319489 189951 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL6 1319489 189952 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL7 1319489 189953 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL8 1319489 189954 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 IL9 1319489 189955 1 and tumor necrosis factor *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 INS 1851758 159009 These results suggest that chimeric receptor activation *stimulates* at least one [serine/threonine kinase] , which in turn phosphorylates the kinase-deficient EGF receptor . Positive_regulation STK39 INS 1902232 156018 We have examined the phosphorylation of the [serine threonine kinase] , the product of c-raf proto-oncogene in *response* to or platelet derived growth factor in intact cells . Positive_regulation STK39 INS 19756449 2175931 Serum and glucocorticoid regulated kinase 1 ( Sgk1 ) is a [serine-threonine kinase] that is *activated* by serum , steroids , , vasopressin , and interleukin 2 at the transcriptional and post-translational levels . Positive_regulation STK39 INS 21952243 2512548 Expression of DNSHP-1 increased *induced* Akt [serine-threonine kinase] phosphorylation and augmented glucose uptake and glycogen synthesis . Positive_regulation STK39 INS 2197270 138006 These findings indicate that *activates* the [serine/threonine kinase] activity of the Raf-1 proto-oncogene by increasing its content of phosphoserine . Positive_regulation STK39 INS 22691550 2633655 Next , we determined that ( 1-10 nm ) inhibited both basal and NE-stimulated ghrelin secretion , *caused* an increase in phosphorylated [serine-threonine kinase] ( AKT ) and a reduction in intracellular cAMP , but did not alter proghrelin mRNA levels . Positive_regulation STK39 INS 23220708 2741081 Insulin induced vasorelaxation due to endothelial nitric oxide synthase (eNOS) activation is highly dependent on the activation of the upstream *stimulated* [serine/threonine kinase] ( AKT ) and is severely impaired in obese , hypertensive rodents and humans . Positive_regulation STK39 INS 2438690 73003 The *stimulated* [serine/threonine kinase] exhibits preferential phosphorylation of histone and Kemptide ( synthetic Leu-Arg-Arg-Ala-Ser-Leu-Gly ) compared to a number of other peptide substrates . Positive_regulation STK39 INS 2438690 73033 The data suggest that this *stimulated* [serine/threonine kinase] in adipocyte high-density microsomes is tyrosine phosphorylated , consistent with the hypothesis that the stimulatory action of insulin on this kinase may be mediated by tyrosine phosphorylation . Positive_regulation STK39 INS 2543402 112672 Chymotryptic digestion was used to localize the sites in microtubule associated protein 2 which are preferentially phosphorylated in vitro by MAP kinase , an *stimulated* [serine/threonine kinase] which efficiently utilizes high molecular weight MAPs as substrates . Positive_regulation STK39 INS 2550926 117661 Stimulation of 3T3-L1 cells with has been shown to *activate* a cytosolic [serine/threonine kinase] capable of phosphorylating microtubule associated protein 2 (MAP-2) and ribosomal protein S6 kinase II . Positive_regulation STK39 INS 2951732 71089 These results show that a soluble [serine/threonine kinase] is rapidly *activated* by , possibly by phosphorylation of either the kinase itself or an interacting modulator . Positive_regulation STK39 INS 9614064 509148 In the present study , we have examined the role of Akt , an *activated* [serine threonine kinase] that has previously been shown to increase glucose transport in adipocytes . Positive_regulation STK39 MAP2K1 10924861 718526 Genistein , a tyrosine kinase inhibitor , H7 , a [serine/threonine kinase] *inhibitor* , and PD 98059 , a inhibitor , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation STK39 MAP2K2 10924861 718527 Genistein , a tyrosine kinase inhibitor , H7 , a [serine/threonine kinase] *inhibitor* , and PD 98059 , a inhibitor , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation STK39 MAP2K3 10924861 718528 Genistein , a tyrosine kinase inhibitor , H7 , a [serine/threonine kinase] *inhibitor* , and PD 98059 , a inhibitor , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation STK39 MAP2K4 10924861 718529 Genistein , a tyrosine kinase inhibitor , H7 , a [serine/threonine kinase] *inhibitor* , and PD 98059 , a inhibitor , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation STK39 MAP2K5 10924861 718530 Genistein , a tyrosine kinase inhibitor , H7 , a [serine/threonine kinase] *inhibitor* , and PD 98059 , a inhibitor , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation STK39 MAP2K6 10924861 718531 Genistein , a tyrosine kinase inhibitor , H7 , a [serine/threonine kinase] *inhibitor* , and PD 98059 , a inhibitor , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation STK39 MAP2K7 10924861 718532 Genistein , a tyrosine kinase inhibitor , H7 , a [serine/threonine kinase] *inhibitor* , and PD 98059 , a inhibitor , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation STK39 MAPK3 17804722 1791200 The ribosomal S6 kinase 2 (RSK2) , a member of the p90 ( RSK ) ( RSK ) family of proteins , is a widely expressed [serine/threonine kinase] that is *activated* by and phosphoinositide dependent kinase 1 in response to many growth factors and peptide hormones . Positive_regulation STK39 MCOLN1 8051124 267630 Furthermore , we identified [serine/threonine kinase] activity associated with p60CD delta 1 that *required* either Mn2+ or for optimal activity . Positive_regulation STK39 MCOLN1 8521077 336403 In the *presence* of , CKII from the yeast Yarrowia lipolytica is autophosphorylated on serines and threonines , and a [serine threonine kinase] activity is found predominantly when casein is used as substrate . Positive_regulation STK39 MST1 10586055 571678 Here we demonstrate that expression of [STK] in RAW264.7 cells resulted in suppression of NO production following IFN-gamma+/- LPS stimulation in the *presence* of , reflecting a decrease in the levels of inducible NO synthase (iNOS) mRNA and protein , which was confirmed by decreased trans-activation of an iNOS reporter . Positive_regulation STK39 MST1 15363108 1304091 Hyal2 does not directly modulate the basal or *induced* [RON/Stk] activity , although it is possible that adaptor proteins might mediate such signaling in other cell types . Positive_regulation STK39 NFKB1 10485710 644351 activation by tumour necrosis factor *requires* the Akt [serine-threonine kinase] . Positive_regulation STK39 PAK1 10954714 744457 Transformation-specific , tyrosine phosphorylation of *enhances* the catalytic activity of this [serine/threonine kinase] . Positive_regulation STK39 PAK2 10954714 744458 Transformation-specific , tyrosine phosphorylation of *enhances* the catalytic activity of this [serine/threonine kinase] . Positive_regulation STK39 PAK3 10954714 744459 Transformation-specific , tyrosine phosphorylation of *enhances* the catalytic activity of this [serine/threonine kinase] . Positive_regulation STK39 PAK4 10954714 744455 Transformation-specific , tyrosine phosphorylation of *enhances* the catalytic activity of this [serine/threonine kinase] . Positive_regulation STK39 PAK6 10954714 744456 Transformation-specific , tyrosine phosphorylation of *enhances* the catalytic activity of this [serine/threonine kinase] . Positive_regulation STK39 PAK7 10954714 744454 Transformation-specific , tyrosine phosphorylation of *enhances* the catalytic activity of this [serine/threonine kinase] . Positive_regulation STK39 PCNA 14712369 1211746 Further tests designed to explore the behavior of Pneumocystis organisms in the lungs of immunocompetent hosts were performed using histological and molecular approaches ( e.g. testing the expression of both *dependent* [serine-threonine kinase] and heat-shock 70 protein in Pneumocystis ) . Positive_regulation STK39 PCNA 8637234 358119 p16(INK4A) and p18 proteins are highly specific inhibitors of *dependent* [serine/threonine kinase] activities required for the overcoming of the G1 checkpoint in the eukaryotic cell division cycle . Positive_regulation STK39 PCNA 8703847 371115 p16INK4A , p15INK4B , and p18 proteins are highly specific inhibitors of *dependent* [serine/threonine kinase] ( CDK ) activities required for GI-S transition in the eukaryotic cell division cycle . Positive_regulation STK39 PI3 14517417 581688 Stimulation of primary bovine capillary endothelial ( BCE ) cells with FGF-2 , VEGF-A ( 165 ) , or a combination of the two induced activity in vitro and subsequent *activation* of the [serine/threonine kinase] Akt . Positive_regulation STK39 PI3 15657037 1381673 Taken together , these data suggest that 1 ) TGFbeta receptors can indirectly associate with p85 , 2 ) both receptors are required for ligand induced PI3 kinase activation , and 3 ) the activated TbetaRI [serine-threonine kinase] can potently *induce* kinase activity . Positive_regulation STK39 PIK3C3 9565622 501046 Akt is a [serine/threonine kinase] that *requires* a functional to be stimulated by insulin and other growth factors . Positive_regulation STK39 PIK3CA 14707136 1219215 Both CD28 and its relative , inducible costimulator (ICOS) , have a binding motif for phosphatidylinositol 3-kinase (PI3K) in their cytoplasmic tail , and the binding of *leads* to activation of a [serine/threonine kinase] , Akt . Positive_regulation STK39 PIK3CA 17000121 1633839 *dependent* activation of the [serine-threonine kinase] , Akt , suppressed CSR , in part , through the inactivation of the Forkhead Box family ( Foxo ) of transcription factors . Positive_regulation STK39 PIK3CA 24043625 2862672 Serum and glucocorticoid regulated kinase 1 ( SGK1 ) encodes a *dependent* [serine/threonine kinase] that is rapidly induced in response to cellular stressors and is an important cell survival signal . Positive_regulation STK39 PIK3CA 8940145 399085 Akt is a [serine/threonine kinase] that *requires* a functional to be stimulated by insulin and other growth factors . Positive_regulation STK39 PIK3R1 14707136 1219216 Both CD28 and its relative , inducible costimulator (ICOS) , have a binding motif for phosphatidylinositol 3-kinase (PI3K) in their cytoplasmic tail , and the binding of *leads* to activation of a [serine/threonine kinase] , Akt . Positive_regulation STK39 PIK3R1 17000121 1633840 *dependent* activation of the [serine-threonine kinase] , Akt , suppressed CSR , in part , through the inactivation of the Forkhead Box family ( Foxo ) of transcription factors . Positive_regulation STK39 PIK3R1 24043625 2862673 Serum and glucocorticoid regulated kinase 1 ( SGK1 ) encodes a *dependent* [serine/threonine kinase] that is rapidly induced in response to cellular stressors and is an important cell survival signal . Positive_regulation STK39 PIK3R1 8940145 399086 Akt is a [serine/threonine kinase] that *requires* a functional to be stimulated by insulin and other growth factors . Positive_regulation STK39 PIK3R4 9565622 501047 Akt is a [serine/threonine kinase] that *requires* a functional to be stimulated by insulin and other growth factors . Positive_regulation STK39 PTK2 23335513 2753462 Thrombin mediated proteoglycan synthesis utilizes both and [serine/threonine kinase] receptor *transactivation* in vascular smooth muscle cells . Positive_regulation STK39 PTK2 23335513 2753552 In contrast , serine/threonine kinase receptor transactivation is mediated by a cytoskeletal rearrangement-Rho kinase-integrin system , and both and [serine/threonine kinase] receptor *transactivation* concomitantly account for the total proteoglycan synthesis stimulated by thrombin in vascular smooth muscle . Positive_regulation STK39 PTK6 23335513 2753463 Thrombin mediated proteoglycan synthesis utilizes both and [serine/threonine kinase] receptor *transactivation* in vascular smooth muscle cells . Positive_regulation STK39 PTK6 23335513 2753553 In contrast , serine/threonine kinase receptor transactivation is mediated by a cytoskeletal rearrangement-Rho kinase-integrin system , and both and [serine/threonine kinase] receptor *transactivation* concomitantly account for the total proteoglycan synthesis stimulated by thrombin in vascular smooth muscle . Positive_regulation STK39 PTK7 23335513 2753464 Thrombin mediated proteoglycan synthesis utilizes both and [serine/threonine kinase] receptor *transactivation* in vascular smooth muscle cells . Positive_regulation STK39 PTK7 23335513 2753554 In contrast , serine/threonine kinase receptor transactivation is mediated by a cytoskeletal rearrangement-Rho kinase-integrin system , and both and [serine/threonine kinase] receptor *transactivation* concomitantly account for the total proteoglycan synthesis stimulated by thrombin in vascular smooth muscle . Positive_regulation STK39 PXN 7534979 297073 We conclude that phosphorylation of talin and occurs during ACh stimulated contraction of tracheal smooth muscle and that distinct signaling pathways *activate* a [serine/threonine kinase] that phosphorylates talin and a tyrosine kinase that phosphorylates paxillin . Positive_regulation STK39 RAC1 15516977 1343117 However , did *promote* activation of the AKT [serine/threonine kinase] . Positive_regulation STK39 RAC1 15814676 1393045 Ligation of 2B4 resulted in the phosphorylation of the guanine nucleotide exchange factor , Vav-1 , and subsequent *activation* of the GTP binding protein ( but not Ras ) and the [serine-threonine kinase] Raf-1 in healthy but not XLP derived NK cells . Positive_regulation STK39 RAC1 9032259 414893 is distinct from RhoA in its ability to bind and *activate* the p65 PAK [serine/threonine kinase] , to induce lamellipodia and membrane ruffling , and to activate the c-Jun NH2-terminal kinase (JNK) . Positive_regulation STK39 RAC1 9755165 535665 This [serine/threonine kinase] is *activated* by GTP bound or Cdc42 . Positive_regulation STK39 RELA 10485710 644352 activation by tumour necrosis factor *requires* the Akt [serine-threonine kinase] . Positive_regulation STK39 RHO 15659308 1364854 Vasoconstrictor factors , like urotensin , angiotensin and catecholamines , activate *dependent* [serine-threonine kinase] ( Rho-kinase ) and inhibition of this pathway represents a novel therapy for cardiovascular diseases with hypertensive syndrome . Positive_regulation STK39 RHO 16336575 1491318 AngII via AngII type 1 receptors activates several intracellular signaling systems , including the small guanosine triphosphatase Rho and its downstream effector *dependent* [serine-threonine kinase] ( Rho-kinase ) . Positive_regulation STK39 RHO 8702756 375978 We have recently identified and molecularly cloned Rho associated [serine/threonine kinase] ( Rho-kinase ) , which is *activated* by GTP ( Matsui , T. , Amano , M. , Yamamoto , T. , Chihara , K. , Nakafuku , M. , Ito , M. , Nakano , T. , Okawa , K. , Iwamatsu , A. , and Kaibuchi , K. ( 1996 ) EMBO J. 15 , 2208-2216 ) . Positive_regulation STK39 RHOA 10329658 613700 Therefore , the possible involvement of the *stimulated* [serine/threonine kinase] , Rho-kinase , was investigated . Positive_regulation STK39 RHOA 10639096 660396 The active , GTP bound form of the small GTPase *activates* a [serine/threonine kinase] , Rho-kinase , that phosphorylates the regulatory subunit of MLCP and inhibits phosphatase activity . Positive_regulation STK39 RHOA 18215121 1883953 ROCK-I ( Rho associated kinase 1 ) is a [serine/threonine kinase] that can be *activated* by and inhibited by RhoE . Positive_regulation STK39 RHOA 21671918 2442832 In somatic cells , *regulates* a [serine/threonine kinase] known as Rho-kinase ( ROCK ) . Positive_regulation STK39 SMO 17089004 1644196 then *activates* STK36 [serine/threonine kinase] to stabilize GLI family members and to phosphorylate SUFU for nuclear accumulation of GLI . Positive_regulation STK39 SPARC 18503049 1945039 *enhanced* signaling by integrin linked kinase (ILK) , a [serine/threonine kinase] known to enhance cell survival in vitro . Positive_regulation STK39 STAT3 17353274 1734045 Here , we demonstrate that Stat3 is required for the Epo independent growth of Friend virus infected cells and that the *activation* of by [Sf-Stk] is mediated by a novel Stat3 binding site in Gab2 . Positive_regulation STK39 STAT3 19581930 2136950 We demonstrate here that *activation* of by [Sf-Stk] in the early stage of disease is essential for the progression of erythroleukemia in the presence of differentiation signals induced by the EpoR , but is dispensable in the late stages of the disease . Positive_regulation STK39 TGFB1 10915727 716637 ( TGF-beta ) *initiates* signaling through heteromeric complexes of transmembrane type I and type II [serine/threonine kinase] receptors . Positive_regulation STK39 TGFB1 19036873 2035238 Immunoblots from hypoxic HPASMC reveal increased *mediated* phosphorylation of the [serine/threonine kinase] ( Akt ) , consistent with hypoxia induced activation of PI3K/Akt signaling pathways to promote proliferation . Positive_regulation STK39 TGFB1 19556242 2117116 TAK1 is a [serine/threonine kinase] that is rapidly *activated* by . Positive_regulation STK39 TGFB2 10915727 716638 ( TGF-beta ) *initiates* signaling through heteromeric complexes of transmembrane type I and type II [serine/threonine kinase] receptors . Positive_regulation STK39 TGFB3 10915727 716639 ( TGF-beta ) *initiates* signaling through heteromeric complexes of transmembrane type I and type II [serine/threonine kinase] receptors . Positive_regulation STK39 TLN1 7534979 297071 We conclude that phosphorylation of and paxillin occurs during ACh stimulated contraction of tracheal smooth muscle and that distinct signaling pathways *activate* a [serine/threonine kinase] that phosphorylates talin and a tyrosine kinase that phosphorylates paxillin . Positive_regulation STK39 TLN2 7534979 297072 We conclude that phosphorylation of and paxillin occurs during ACh stimulated contraction of tracheal smooth muscle and that distinct signaling pathways *activate* a [serine/threonine kinase] that phosphorylates talin and a tyrosine kinase that phosphorylates paxillin . Positive_regulation STK39 TNF 11287630 800298 inhibited insulin promoted tyrosine phosphorylation of IRS-1 and *activated* the Akt/protein kinase B [serine-threonine kinase] , a downstream target for phosphatidylinositol 3-kinase ( PI 3-kinase ) . Positive_regulation STK39 TNF 1319489 189929 Interleukin 1 and *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK39 VEGFA 16537812 1574435 Moreover , loss of gng2 function inhibits the ability of VEGF to promote the angiogenic sprouting of blood vessels by attenuating *induced* phosphorylation of phospholipase C-gamma1 ( PLCgamma1 ) and [serine/threonine kinase] ( AKT ) . Positive_regulation STK4 ANGPT1 15501241 1327034 VEGF treatment of cultured smooth muscle cells (SMC) upregulated Tie2 and allowed for *mediated* phosphorylation of Tie2 and the AKT [serine-threonine kinase] . Positive_regulation STK4 FAS 19062280 2001793 NDR kinase is activated by [RASSF1A/MST1] in *response* to receptor stimulation and promotes apoptosis . Positive_regulation STK4 FAS 19062280 2001800 receptor stimulation *promoted* direct phosphorylation and activation of NDR1/2 by the [mammalian STE20-like kinase 1 (MST1)] , a downstream effector of RASSF1A . Positive_regulation STK4 FAS 9545236 498406 *induced* cleavage of [Mst1] was blocked by the cysteine protease inhibitor ZVAD-fmk , the more selective caspase inhibitor DEVD-CHO and by the viral serpin CrmA . Positive_regulation STK4 GPR115 20625315 2328623 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK4 GPR132 20625315 2328612 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK4 GPR87 20625315 2328692 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK4 IGFBP1 10792618 689404 The IGFBP-5 stimulatory pathway is mediated by the [serine/threonine kinase] IGFBP-5 receptor , which is *activated* by the carboxy-terminal peptide . Positive_regulation STK4 MAP2K6 10924861 718503 Genistein , a tyrosine kinase inhibitor , H7 , a [serine/threonine kinase] *inhibitor* , and PD 98059 , a inhibitor , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation STK4 TNF 11287630 800294 inhibited insulin promoted tyrosine phosphorylation of IRS-1 and *activated* the Akt/protein kinase B [serine-threonine kinase] , a downstream target for phosphatidylinositol 3-kinase ( PI 3-kinase ) . Positive_regulation STK4 TNF 1319489 189817 Interleukin 1 and *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STK4 TNF 18182160 1856526 Western blot analysis revealed that *induced* activation of caspase 3 and [Mst1] in a time- and dose dependent manner . Positive_regulation STK4 TNF 18182160 1856530 Diphenyleneiodonium , an inhibitor of NADPH oxidase , and N-acetylcysteine , a potent antioxidant , also inhibited *induced* activation of [Mst1] and caspase 3 , as well as apoptosis . Positive_regulation STK4 TNF 23085515 2713719 Furthermore , prevented the physical interaction between thioredoxin-1 and MST1 and *promoted* the homodimerization and activation of [MST1] . Positive_regulation STK40 ANGPT1 15501241 1327041 VEGF treatment of cultured smooth muscle cells (SMC) upregulated Tie2 and allowed for *mediated* phosphorylation of Tie2 and the AKT [serine-threonine kinase] . Positive_regulation STK40 GPR115 20625315 2329181 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK40 GPR132 20625315 2329170 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK40 GPR87 20625315 2329250 We utilized human vascular smooth muscle cells to address the question if a , the endothelin (ET) receptor , could *transactivate* a [serine/threonine kinase] receptor , specifically the transforming growth factor (TGF)-[beta ] receptor , T [ beta ] RI . Positive_regulation STK40 IGFBP1 10792618 689446 The IGFBP-5 stimulatory pathway is mediated by the [serine/threonine kinase] IGFBP-5 receptor , which is *activated* by the carboxy-terminal peptide . Positive_regulation STK40 MAP2K6 10924861 718545 Genistein , a tyrosine kinase inhibitor , H7 , a [serine/threonine kinase] *inhibitor* , and PD 98059 , a inhibitor , prevented the UVA induced enhancement of STAT1 binding activity , suggesting the involvement of Tyr , Ser/Thr kinases , and MEK in the observed effect . Positive_regulation STK40 TNF 11287630 800300 inhibited insulin promoted tyrosine phosphorylation of IRS-1 and *activated* the Akt/protein kinase B [serine-threonine kinase] , a downstream target for phosphatidylinositol 3-kinase ( PI 3-kinase ) . Positive_regulation STK40 TNF 1319489 189985 Interleukin 1 and *activate* [serine/threonine kinase] activity in cells within minutes of receptor interaction . Positive_regulation STMN1 EPHB2 19241002 2040542 We demonstrate the utility of this approach by studying the *dependent* changes in [stathmin] phosphorylation induced by NGF in primary sympathetic neurons . Positive_regulation STMN1 MAP2K6 19241002 2040548 We demonstrate the utility of this approach by studying the *dependent* changes in [stathmin] phosphorylation induced by NGF in primary sympathetic neurons . Positive_regulation STMN2 CAPN8 16822511 1612805 Taxol and tau overexpression induced *dependent* degradation of the microtubule destabilizing [protein SCG10] . Positive_regulation STMN2 CAPN8 16822511 1612846 Collectively , these results indicate that tau overexpression and Taxol treatment induced a *dependent* degradation of the microtubule destabilizing [protein SCG10] . Positive_regulation STRA8 MSX1 22071108 2508433 In F9 cells , can bind to Stra8 regulatory sequences and Msx1 overexpression *stimulates* [Stra8] transcription . Positive_regulation STRAP SMN2 10901626 712863 Immunolocalization studies using SMN monoclonal antibody showed that is decreased in cultures grown in low K+ or chemically defined medium with respect to cultures grown in high K+ medium and that an increase of [SMN] can be *induced* by treatment of low K+ cultures with glutamate or N-methyl-D-aspartate . Positive_regulation STS ANGPT1 23486192 2787636 We examined whether [ASC] produced angiopoietin-1 (Ang1) and whether functionally *mediated* ASC induced suppression of neointimal formation . Positive_regulation STS FAS 12054656 951301 The mediated *induction* of [ASC] was inhibited by a general caspase inhibitor , z-VAD-fmk , and an immunocytochemical study showed that ASC was increased in neutrophils exhibiting characteristic phenotypes for apoptosis . Positive_regulation STS IL1B 12054656 951300 [ASC] expression was transiently *up-regulated* by IL-1alpha , , IFN-alpha , IFN-gamma , TNFalpha , and LPS . Positive_regulation STS IL1B 12201223 982996 IL-6 and *stimulated* the activity of Arom and [STS] . Positive_regulation STS IL1B 15020601 1243440 Thus , cryopyrin mediated secretion *requires* [ASC] in monocytic cells . Positive_regulation STS MAP2K6 16440327 1554583 Additionally , 1alpha,25 ( OH ) ( 2 ) D ( 3 ) -induced [STS] activity was *attenuated* by inhibitors of RAS ( manumycin A ) , RAF ( GW5074 ) , ( PD098059 and U1026 ) and JNK ( SP600125 ) , but not p38 ( PD169316 ) . Positive_regulation STS TNF 11282280 764736 The cytokine or the STS inhibitor , 2-methoxyoestrone-3-O-sulphamate , *had* no effect on [STS] mRNA expression in fibroblasts . Positive_regulation STS TNF 11282280 764738 plus IL-6 *increased* [STS] activity in mock transfected MCF-7 cells and further increased STS activity in transfected MCF-7 cells . Positive_regulation STS TNF 12054656 951298 [ASC] expression was transiently *up-regulated* by IL-1alpha , IL-1beta , IFN-alpha , IFN-gamma , , and LPS . Positive_regulation STS TNF 16715133 1638301 *Induction* of [TMS1/ASC] by was blocked by co-expression of a dominant negative IkappaBalpha , small interfering RNA mediated knockdown of RelA/p65 , or concurrent treatment with SP600125 , indicating a requirement for the nuclear factor-kappaB (NF-kappaB) and jun kinase signaling pathways . Positive_regulation STS TNF 16715133 1638312 Taken together , these data suggest that *upregulation* of [TMS1/ASC] by and subsequent activation of caspase-8 could function to amplify the apoptotic signal induced by death receptors in some cell types , including breast epithelial cells . Positive_regulation STS TNF 21904110 2511211 *Induction* of [steroid sulfatase] expression by through phosphatidylinositol 3-kinase/Akt signaling pathway in PC-3 human prostate cancer cells . Positive_regulation STS TNF 21904110 2511213 Treatment with TNF-a resulted in a strong increase in the phosphorylation of Akt on Ser-473 and when cells were treated with phosphatidylinositol (PI) 3-kinase inhibitors such as LY294002 or wortmannin , or Akt inhibitor ( Akt inhibitor IV ) , *induction* of [STS] mRNA expression by was significantly prevented . Positive_regulation STS TNF 21904110 2511217 Moreover , activation of Akt1 by expressing the constitutively active form of Akt1 increased STS expression whereas dominant negative Akt suppressed *mediated* [STS] induction . Positive_regulation STS TNF 21904110 2511219 We also found that is able to *increase* [STS] mRNA expression in other human cancer cells such as LNCaP , MDA-MB-231 , and MCF-7 as well as PC-3 cells . Positive_regulation STS TNF 24009850 2714636 Previously , we found that significantly *enhances* [steroid sulfatase] expression in PC-3 human prostate cancer cells through PI3K/Akt dependent pathways . Positive_regulation STSP1 TNFSF10 22992678 2698006 Fura-2 imaging demonstrated that [Stsp] *induced* a rapid and modest rise in calcium that was sustained over the course of AVD , while produced no detectable rise in global intracellular calcium . Positive_regulation STX10 SYT8 10617122 656724 Stimulation of Ca2+/calmodulin dependent protein kinase II , which endogenously phosphorylates synaptotagmin in synaptic vesicles , *increased* the interaction of [syntaxin] and SNAP-25 with ( particularly when measured in the presence of calcium ) , as well as increasing the binding of the kinase itself . Positive_regulation STX11 SYT8 10617122 656741 Stimulation of Ca2+/calmodulin dependent protein kinase II , which endogenously phosphorylates synaptotagmin in synaptic vesicles , *increased* the interaction of [syntaxin] and SNAP-25 with ( particularly when measured in the presence of calcium ) , as well as increasing the binding of the kinase itself . Positive_regulation STX12 SYT8 10617122 656758 Stimulation of Ca2+/calmodulin dependent protein kinase II , which endogenously phosphorylates synaptotagmin in synaptic vesicles , *increased* the interaction of [syntaxin] and SNAP-25 with ( particularly when measured in the presence of calcium ) , as well as increasing the binding of the kinase itself . Positive_regulation STX16 SYT8 10617122 656775 Stimulation of Ca2+/calmodulin dependent protein kinase II , which endogenously phosphorylates synaptotagmin in synaptic vesicles , *increased* the interaction of [syntaxin] and SNAP-25 with ( particularly when measured in the presence of calcium ) , as well as increasing the binding of the kinase itself . Positive_regulation STX16 SYT8 17625073 1829071 Previous studies indicate that the process requires Rab3 dependent tethering of membranes , [SNARE complex] assembly , and Ca2+ mediated *activation* of . Positive_regulation STX17 SYT8 10617122 656792 Stimulation of Ca2+/calmodulin dependent protein kinase II , which endogenously phosphorylates synaptotagmin in synaptic vesicles , *increased* the interaction of [syntaxin] and SNAP-25 with ( particularly when measured in the presence of calcium ) , as well as increasing the binding of the kinase itself . Positive_regulation STX18 SYT8 10617122 656911 Stimulation of Ca2+/calmodulin dependent protein kinase II , which endogenously phosphorylates synaptotagmin in synaptic vesicles , *increased* the interaction of [syntaxin] and SNAP-25 with ( particularly when measured in the presence of calcium ) , as well as increasing the binding of the kinase itself . Positive_regulation STX19 SYT8 10617122 656928 Stimulation of Ca2+/calmodulin dependent protein kinase II , which endogenously phosphorylates synaptotagmin in synaptic vesicles , *increased* the interaction of [syntaxin] and SNAP-25 with ( particularly when measured in the presence of calcium ) , as well as increasing the binding of the kinase itself . Positive_regulation STX1A TNF 15633106 1362515 Exposure of human brain endothelial cells ( HBECs ) to greatly *increased* [Stx-1] and Stx-2 cytotoxicity ; Positive_regulation STX1A TNF 15633106 1362516 SB203580 , a specific inhibitor of p38 MAPK , reduced TNF stimulated Stx cytotoxicity in HBECs , *stimulated* ( 125 ) [Stx-1] binding to intact HBECs , the cellular content of Gb3 ( galactose alpha 1,4 , galactose ss 1,4 , glucose-ceramide ) ( the Stx receptor ) , and TNF stimulated Gb3 synthase and glucosylceramide synthase activities but did not affect lactosylceramide synthase activities or mRNA content . Positive_regulation STX1B IL1B 15102770 1239919 Compared to LPS , Stx1 was a poor inducer of IL-1beta protein expression , although levels of soluble IL-1beta induced by all treatments continually increased over 72 h . transcripts were not *induced* by [Stx1 B-subunits] . Positive_regulation STX2 PLAU 17935821 1819792 In vitro , [epimorphin] *induced* matrix metalloproteinase (MMP) 9 , MMP 3 and ( uPA ) in hepatocytes . Positive_regulation STX2 SYT8 10617122 656945 Stimulation of Ca2+/calmodulin dependent protein kinase II , which endogenously phosphorylates synaptotagmin in synaptic vesicles , *increased* the interaction of [syntaxin] and SNAP-25 with ( particularly when measured in the presence of calcium ) , as well as increasing the binding of the kinase itself . Positive_regulation STX3 SYT8 10617122 656809 Stimulation of Ca2+/calmodulin dependent protein kinase II , which endogenously phosphorylates synaptotagmin in synaptic vesicles , *increased* the interaction of [syntaxin] and SNAP-25 with ( particularly when measured in the presence of calcium ) , as well as increasing the binding of the kinase itself . Positive_regulation STX4 SYT8 10617122 656826 Stimulation of Ca2+/calmodulin dependent protein kinase II , which endogenously phosphorylates synaptotagmin in synaptic vesicles , *increased* the interaction of [syntaxin] and SNAP-25 with ( particularly when measured in the presence of calcium ) , as well as increasing the binding of the kinase itself . Positive_regulation STX4 SYT8 12526776 1048185 Thus , triggering of the fast component of release by Sr ( 2+ ) as a Ca ( 2+ ) agonist involves the formation of complexes , but does not *require* stimulated [SNARE] binding . Positive_regulation STX5 SYT8 10617122 656843 Stimulation of Ca2+/calmodulin dependent protein kinase II , which endogenously phosphorylates synaptotagmin in synaptic vesicles , *increased* the interaction of [syntaxin] and SNAP-25 with ( particularly when measured in the presence of calcium ) , as well as increasing the binding of the kinase itself . Positive_regulation STX6 SYT8 10617122 656860 Stimulation of Ca2+/calmodulin dependent protein kinase II , which endogenously phosphorylates synaptotagmin in synaptic vesicles , *increased* the interaction of [syntaxin] and SNAP-25 with ( particularly when measured in the presence of calcium ) , as well as increasing the binding of the kinase itself . Positive_regulation STX7 SYT8 10617122 656877 Stimulation of Ca2+/calmodulin dependent protein kinase II , which endogenously phosphorylates synaptotagmin in synaptic vesicles , *increased* the interaction of [syntaxin] and SNAP-25 with ( particularly when measured in the presence of calcium ) , as well as increasing the binding of the kinase itself . Positive_regulation STX8 SYT8 10617122 656894 Stimulation of Ca2+/calmodulin dependent protein kinase II , which endogenously phosphorylates synaptotagmin in synaptic vesicles , *increased* the interaction of [syntaxin] and SNAP-25 with ( particularly when measured in the presence of calcium ) , as well as increasing the binding of the kinase itself . Positive_regulation SULF1 TNF 11879566 919189 The activities of the aromatase , estradiol 17beta-hydroxysteroid dehydrogenase and estrone [sulfatase] are all *increased* by IL-6 and . Positive_regulation SULF2 TNF 11879566 919191 The activities of the aromatase , estradiol 17beta-hydroxysteroid dehydrogenase and estrone [sulfatase] are all *increased* by IL-6 and . Positive_regulation SULT1E1 ARSG 11073983 748898 was *required* for the altered localization of [Ste4p] that occurs during receptor inhibition , and the subcellular location of Asg7p was consistent with its having a direct effect on Ste4p localization . Positive_regulation SULT2A1 IL1B 18566370 1929604 Consistent with its regulatory function , *induced* [ST2L] expression suppressed the responsiveness of RAPA-DC to TLR or CD40 ligation . Positive_regulation SULT2A1 IL1B 18566370 1929605 Thus , as a *result* of their de novo production of , RAPA-DC up-regulate [ST2L] and become refractory to proinflammatory , maturation inducing stimuli . Positive_regulation SULT2A1 SMN2 24023879 2842022 Furthermore , depletion of *inhibited* nuclear import of fluorescently labeled recombinant [aB-STD] in an in vitro nuclear import assay , which could be restored by the addition of purified SMN complex . Positive_regulation SULT2A1 TNF 11207266 786883 Exogenous IL-6 , IL-5 , IL-1 , and *enhanced* the expression of [T1/ST2] on Th2 cells , and IL-6 was by far most effective in this regard . Positive_regulation SUMO1 EPHB2 16713578 1564960 While PIASxalpha functions as a coactivator to facilitate [SUMO] and HDAC-2 removal from Elk-1 in *response* to pathway activation , PIASxalpha acts in the opposite manner to inhibit HDAC-2 and SUMO loss following stress activated MAP kinase pathway signaling . Positive_regulation SUMO2 EPHB2 16713578 1564959 While PIASxalpha functions as a coactivator to facilitate [SUMO] and HDAC-2 removal from Elk-1 in *response* to pathway activation , PIASxalpha acts in the opposite manner to inhibit HDAC-2 and SUMO loss following stress activated MAP kinase pathway signaling . Positive_regulation SUMO2 TNF 23417988 2843320 In vitro , the expression of [SUMO-2] but not of SUMO-3 was *induced* by . Positive_regulation SUMO2 TNF 23417988 2843329 Collectively , we show that despite their high homology , [SUMO-2/3] are differentially *regulated* by and selectively control TNF-a mediated MMP expression via the NF-?B pathway . Positive_regulation SUMO3 EPHB2 16713578 1564958 While PIASxalpha functions as a coactivator to facilitate [SUMO] and HDAC-2 removal from Elk-1 in *response* to pathway activation , PIASxalpha acts in the opposite manner to inhibit HDAC-2 and SUMO loss following stress activated MAP kinase pathway signaling . Positive_regulation SUMO3 TNF 23417988 2843319 In vitro , the expression of SUMO-2 but not of [SUMO-3] was *induced* by . Positive_regulation SUMO3 TNF 23417988 2843328 Collectively , we show that despite their high homology , [SUMO-2/3] are differentially *regulated* by and selectively control TNF-a mediated MMP expression via the NF-?B pathway . Positive_regulation SUMO4 EPHB2 16713578 1564961 While PIASxalpha functions as a coactivator to facilitate [SUMO] and HDAC-2 removal from Elk-1 in *response* to pathway activation , PIASxalpha acts in the opposite manner to inhibit HDAC-2 and SUMO loss following stress activated MAP kinase pathway signaling . Positive_regulation SUZ12 ZFP57 20808772 2313996 Levels of both and PcG proteins inversely correlated with those of reactive oxygen species ( ROS ) in senescing MEFs , but the treatment of Zfp277 ( -/- ) MEFs with an antioxidant *restored* the binding of [PRC2] but not PRC1 to the Ink4a/Arf locus . Positive_regulation SYK EPHB2 10415002 631129 A direct serine phosphorylation and *activation* of [Syk] by was observed in in vitro experiments . Positive_regulation SYK EPHB2 24569586 2924748 An EBV infection in HCECs can lead to a mesenchymal fibroblast-like morphology , and cause EMT through the *activation* of PI3K/Akt and by TGF-ß1 mediated [Syk] and Src signaling . Positive_regulation SYK F2R 8780738 380219 Both thrombin and *activated* [p72syk] and p60c-src with similar magnitudes . Positive_regulation SYK IL1B 20401456 2282154 Recent work has uncovered essential *roles* for the [spleen tyrosine kinase (SYK)] and the cytosolic NLRP3 inflammasome for production in innate antifungal immunity . Positive_regulation SYK ITGB2 10222060 609558 Furthermore , costimulation with CD3 *induces* tyrosine phosphorylation of [Syk] associated with FAK . Positive_regulation SYK TNF 15240695 1270296 also *activated* [Syk] in myeloid and epithelial cells . Positive_regulation SYK TNF 15240695 1270310 Jurkat cells that did not express Syk ( JCaM1 , JCaM1/lck ) showed lack of *induced* [Syk] , JNK , p38 MAPK , and p44/p42 MAPK activation , as well as TNF induced IkappaBalpha phosphorylation , IkappaBalpha degradation , and NF-kappaB activation . Positive_regulation SYK TNF 15240695 1270338 Immunoprecipitation of cells with Syk Abs showed *dependent* association of [Syk] with both TNFR1 and TNFR2 ; Positive_regulation SYK TNF 16275893 1502470 However , their differential effects on cell spreading , bacteria induced RB , TNF induced degranulation , TNF induced protein tyrosine phosphorylation , and *induced* [Syk] activation suggested that each may act on different elements of neutrophil signaling pathways . Positive_regulation SYK TNF 23319318 2733175 *increased* tyrosine phosphorylation of [Syk] , which was attenuated by NAC and MPA . Positive_regulation SYK TNF 23726836 2819760 TMP significantly inhibited *induced* phosphorylation of [Syk] and PI3K . Positive_regulation SYMPK CFI 11713271 880784 In Saccharomyces cerevisiae , in vitro mRNA cleavage and [polyadenylation] *require* the poly ( A ) binding protein , Pab1p , and two multiprotein complexes : ( cleavage factor I ) and CPF ( cleavage and polyadenylation factor ) . Positive_regulation SYMPK LGALS7B 9174099 433502 Northern blot analysis , PCR amplification , and DNA sequence analysis show that the signal *directs* [polyadenylation] within the body of pre-SUP4 and within the terminator , suggesting that polyadenylation inhibits 5 ' and 3 ' end processing , as well as removal of the pre-tRNA intron . Positive_regulation SYN1 EPHB2 16237176 1470805 Consistent with a presynaptic function for endogenous H-ras/extracellular signal regulated kinase ( ERK ) signaling , we observed that , under normal physiologic conditions in wild-type mice , hippocampus dependent learning stimulated the *dependent* phosphorylation of [synapsin I] , and MEK ( MAP kinase kinase ) /ERK inhibition selectively decreased the frequency of miniature EPSCs . Positive_regulation SYN1 EPHB2 16237176 1470807 By generating transgenic mice expressing a constitutively active form of H-ras ( H-rasG12V ) , which is abundantly localized in axon terminals , we were able to increase the *dependent* phosphorylation of [synapsin I] . Positive_regulation SYN1 EPHB2 17105652 1663632 Cultivation of mouse synovial fibroblasts with IL-1beta activates mitogen activated protein kinases , including extra-cellular signal regulated kinase ( Erk ) , JNK ( c-Jun N-terminal kinase ) , and p38 , while only inhibitor *blocks* IL-1beta induced [SYN] expression . Positive_regulation SYN1 EPHB2 17105652 1663647 Inhibition of activation *reduces* ETS1 phosphorylation and [SYN] expression . Positive_regulation SYN1 EPHB2 20159961 2214810 However , the physiological role of *dependent* [synapsin] phosphorylation in regulating synaptic formation and function is poorly understood . Positive_regulation SYN1 EPHB2 20159961 2214894 Our findings show that *dependent* [synapsin] phosphorylation has a dual role both in the establishment of functional synaptic connections and their short-term plasticity , indicating that some of the multiple extranuclear functions of MAPK/Erk in neurons can be mediated by the same multifunctional presynaptic target . Positive_regulation SYN1 EPHB2 20399245 2262269 A specific inhibitor , U0126 , *reduced* the [synapsin I-area] without affecting the MAP2-area . Positive_regulation SYN1 EPHB2 23715865 2811528 Furthermore , fourth ventricle injection of an NMDAR antagonist or the mitogen activated kinase inhibitor *blocked* CCK induced [synapsin I] phosphorylation , indicating that synapsin phosphorylation in vagal afferent terminals depends on NMDAR activation and ERK1/2 phosphorylation . Positive_regulation SYN1 IL1B 17105652 1663633 Cultivation of mouse synovial fibroblasts with IL-1beta activates mitogen activated protein kinases , including extra-cellular signal regulated kinase ( Erk ) , JNK ( c-Jun N-terminal kinase ) , and p38 , while only Erk-specific inhibitor blocks *induced* [SYN] expression . Positive_regulation SYN1 IL1B 17105652 1663639 Expression of transcription factor ETS1 further enhances *induced* [SYN] expression . Positive_regulation SYN1 WNT7A 9405095 469717 induces axonal remodeling and *increases* [synapsin I] levels in cerebellar neurons . Positive_regulation SYN1 WNT7A 9405095 469718 Moreover , *increases* the levels of [synapsin I] , a presynaptic protein involved in synapse formation and function . Positive_regulation SYN2 EPHB2 17105652 1663634 Cultivation of mouse synovial fibroblasts with IL-1beta activates mitogen activated protein kinases , including extra-cellular signal regulated kinase ( Erk ) , JNK ( c-Jun N-terminal kinase ) , and p38 , while only inhibitor *blocks* IL-1beta induced [SYN] expression . Positive_regulation SYN2 EPHB2 17105652 1663648 Inhibition of activation *reduces* ETS1 phosphorylation and [SYN] expression . Positive_regulation SYN2 EPHB2 20159961 2214824 However , the physiological role of *dependent* [synapsin] phosphorylation in regulating synaptic formation and function is poorly understood . Positive_regulation SYN2 EPHB2 20159961 2214908 Our findings show that *dependent* [synapsin] phosphorylation has a dual role both in the establishment of functional synaptic connections and their short-term plasticity , indicating that some of the multiple extranuclear functions of MAPK/Erk in neurons can be mediated by the same multifunctional presynaptic target . Positive_regulation SYN2 IL1B 17105652 1663635 Cultivation of mouse synovial fibroblasts with IL-1beta activates mitogen activated protein kinases , including extra-cellular signal regulated kinase ( Erk ) , JNK ( c-Jun N-terminal kinase ) , and p38 , while only Erk-specific inhibitor blocks *induced* [SYN] expression . Positive_regulation SYN2 IL1B 17105652 1663641 Expression of transcription factor ETS1 further enhances *induced* [SYN] expression . Positive_regulation SYN3 EPHB2 17105652 1663636 Cultivation of mouse synovial fibroblasts with IL-1beta activates mitogen activated protein kinases , including extra-cellular signal regulated kinase ( Erk ) , JNK ( c-Jun N-terminal kinase ) , and p38 , while only inhibitor *blocks* IL-1beta induced [SYN] expression . Positive_regulation SYN3 EPHB2 17105652 1663649 Inhibition of activation *reduces* ETS1 phosphorylation and [SYN] expression . Positive_regulation SYN3 EPHB2 20159961 2214838 However , the physiological role of *dependent* [synapsin] phosphorylation in regulating synaptic formation and function is poorly understood . Positive_regulation SYN3 EPHB2 20159961 2214922 Our findings show that *dependent* [synapsin] phosphorylation has a dual role both in the establishment of functional synaptic connections and their short-term plasticity , indicating that some of the multiple extranuclear functions of MAPK/Erk in neurons can be mediated by the same multifunctional presynaptic target . Positive_regulation SYN3 IL1B 17105652 1663637 Cultivation of mouse synovial fibroblasts with IL-1beta activates mitogen activated protein kinases , including extra-cellular signal regulated kinase ( Erk ) , JNK ( c-Jun N-terminal kinase ) , and p38 , while only Erk-specific inhibitor blocks *induced* [SYN] expression . Positive_regulation SYN3 IL1B 17105652 1663643 Expression of transcription factor ETS1 further enhances *induced* [SYN] expression . Positive_regulation SYNCRIP TNF 12040173 949655 A common feature of each pathway is the *induced* formation of a [multiprotein] signaling complex at the cell membrane . Positive_regulation SYNM AGRP 10868932 706581 At 8 h postinjection , *increased* feeding in the PVN by 218 +/- 23 % ( P < 0.005 ) , in the [DMN] by 268 +/- 42 % ( P < 0.005 ) , and in the MPO by 236 +/- 31 % ( P < 0.01 ) compared with a saline control group for each nucleus . Positive_regulation SYNM CCL4 7523919 272305 UDS induced by [DMN] and RDS *induced* by were 19.4 and 3.3 % for ad libitum feeding , 34.5 and 10.4 % for restricted feeding , and 47.8 and 15.1 % for fasting . Positive_regulation SYNM IHH 23500635 2766658 *increased* OxR1 in the DMN , PVN , VMN and SONr ( P < 0.01 for all ) , and OxR2 in [DMN] ( P < 0.001 ) , PFA ( P=0.001 ) , PVN ( P=0.004 ) , VMN ( P=0.041 ) and the TMN ( P < 0.001 ) . Positive_regulation SYNM MBD2 6413080 30571 The results are discussed in terms of what is known about the *role* of in the metabolic activation of [DMN] in other systems . Positive_regulation SYNM MBD2 6790803 16522 The mothers ' livers were also less responsive to [DMN] *induction* by PCB 's during the last 5 days of gestation in comparison with the response earlier in pregnancy or just after delivery . Positive_regulation SYNM MBD2 7030474 17847 The requirement for the cytosolic fraction may indicate that DMN is not *sufficient* for the activation of [DMN] to a mutagen under the conditions used in these studies . Positive_regulation SYNM MBD2 7379044 11357 Only L-tryptophan *induces* I and only L-tryptophan and 3-indolylmethanol induce [DMN-demethylase] II , representing a doubling of enzyme activity in all 3 instances . Positive_regulation SYNM NPFF 17936900 1825571 The [DMN] , DMP , PVN and VMH were all *activated* by ICV while the LH was not affected . Positive_regulation SYNM PC 6790803 16523 The mothers ' livers were also less responsive to [DMN] demethylase *induction* by 's during the last 5 days of gestation in comparison with the response earlier in pregnancy or just after delivery . Positive_regulation SYNM PRPH2 9788584 541847 In the repeated-dose study , [DMN] ( 4 mg/kg bw ) *induced* both and hepatotoxicity , but MNU ( 10 mg/kg bw ) induced neither . Positive_regulation SYNM TAPBP 23657147 2795982 It has been found that reasoning about internal mental states is associated with *activation* of the [default mode network (DMN)] and deactivation of the ; Positive_regulation SYNM TRH 3139260 97366 This study evaluated the hypothesis that the [dorsal motor nucleus (DMN)] of the brainstem may *mediate* the ulcerogenic and acid-stimulatory effects of in rats . Positive_regulation SYP NNMT 23764850 2798321 Expression of in SH-SY5Y human neuroblastoma and N27 rat mesencephalic dopaminergic neurones *increased* neurite branching , [synaptophysin] expression and dopamine accumulation and release . Positive_regulation SYT1 EPHB2 17189385 1662759 In addition , inhibitor ( PD98059 ) *reduced* the interaction between [p65] and ERK . Positive_regulation SYT1 EPHB2 17891781 1888853 Furthermore , inhibitors ( U0126 and PD98059 ) *suppressed* LPA stimulated activation of NF-kappaB and [p65] phosphorylation whereas wortmannin showed no effect on NF-kappaB activation . Positive_regulation SYT1 F2R 16467309 1548176 Activation of or PAR-2 *promoted* nuclear translocation and phosphorylation of [p65-NF-kappaB] , and thrombin induced but not PAR-2 induced p65-NF-kappaB phosphorylation was reduced by inhibition of MEK or p38MAPK . Positive_regulation SYT1 FAS 10022897 590535 Activation dependent transcriptional regulation of the human promoter *requires* NF-kappaB [p50-p65] recruitment . Positive_regulation SYT1 FAS 9500443 490765 Inhibition of caspase-3 related proteases by a specific acetylated aldehyde ( Ac-DEVD-CHO ) prevented *induced* cleavage of [p65] ( RelA ) or p50 and restored the inducibility of NF-kappaB in cells treated with an antibody against CD95 . Positive_regulation SYT1 HSD11B2 19776225 2232021 Moreover , <11 beta-HSD1> inhibitors *attenuated* TNF-alpha induced phosphorylation of NF-kappaB [p65] and p38- , JNK- , and ERK1/2-MAPK . Positive_regulation SYT1 IL1B 15543947 1337756 The colon derived HT-29 cell line likewise activated both p65-p50 and p50-p50 NF-kappaB complexes : TNF-alpha triggered a strong , sustained p65-p50 activation with lower relative levels of p50-p50 , whereas transiently *activated* [p65-p50] with higher relative levels of p50-p50 . Positive_regulation SYT1 IL1B 15659543 1375893 Western-blot analysis revealed that *enhanced* NF-kappaB [p65] and p50 proteins by 1.7- and 3.6-fold , respectively , whereas moxifloxacin inhibited the proteins by up to 60 % . Positive_regulation SYT1 IL1B 16272352 1479486 *stimulated* the translocation of [p65] and p50 from the cytosol to the nucleus of human RA synovial fibroblasts , as well as NF-kappaB activation measured by luciferase reporter assay . Positive_regulation SYT1 IL1B 16317111 1518956 In addition , fluvastatin increased *induced* [p65] nuclear translocation and nuclear factor kappaB (NF-kappaB) activity , although it inhibited those induced by LPS . Positive_regulation SYT1 IL1B 16804400 1579581 Pretreatment of human epithelial HT-29 cells with gliotoxin significantly blocked the I-kappaB degradation and NF-kappaB [p65] nuclear translocation *induced* by tumor necrosis factor-alpha or ; Positive_regulation SYT1 IL1B 17068060 1693030 Finally , the [p65] nuclear translocation *induced* by was also strongly decreased by E2 . Positive_regulation SYT1 IL1B 19369446 2081720 Inhibition of GSK3beta abolished *induced* phosphorylation of [IKK2/p65] . Positive_regulation SYT1 IL1B 19370157 2058812 This suppression of NOS2 by DCS correlates with the attenuation of the NF-kappaB signaling pathway as measured by *induced* phosphorylation of the inhibitor of kappa B (IkappaB)-alpha , degradation of IkappaB-alpha and IkappaB-beta , and subsequent nuclear translocation of NF-kappaB [p65] . Positive_regulation SYT1 IL1B 19843519 2170108 Immunoprecipitation and chromatin immunoprecipitation experiments showed that *stimulates* [p65] interaction with IRF-1 and the accumulation of both factors at the PDGF-D promoter . Positive_regulation SYT1 IL1B 9662438 518264 In non transfected C127 cells , signalled through the mIL-1RI-mIL-1RAcP complex and *activated* NFkappaB [p50/p65] heterodimers . Positive_regulation SYT1 IL1B 9662438 518269 In C127-hIL-1RI cells , signalled through the hIL-1RI and *activated* both p65/p65 and [p50/p65] NFkappaB complexes , where only the activation of NFkappaB p65/p65 was dependent on mIL-1RAcP . Positive_regulation SYT1 MAP2K6 16467309 1548184 Activation of PAR-1 or PAR-2 promoted nuclear translocation and phosphorylation of [p65-NF-kappaB] , and thrombin induced but not PAR-2 induced p65-NF-kappaB phosphorylation was *reduced* by inhibition of or p38MAPK . Positive_regulation SYT1 MAP2K6 17189385 1662765 In addition , inhibitor ( PD98059 ) *reduced* the interaction between [p65] and ERK . Positive_regulation SYT1 NES 21158742 2384807 In genetically modified p65-/- cells , the localization of ectopic [p65] is not solely regulated by I?Ba , but is largely *dependent* on the NLS ( nuclear localization signal ) and the ( nuclear export signal ) of p65 . Positive_regulation SYT1 RAB31 17625073 1829100 Previous studies indicate that the process requires *dependent* tethering of membranes , SNARE complex assembly , and Ca2+ mediated activation of [synaptotagmin] . Positive_regulation SYT1 SPHK1 24173614 2889780 Mechanistically , treatment with DMS suppressed the *activation* of and nuclear factor-?B ( NF-?B ) [p65] , but increased intracellular [ Ca2+ ] i in A549 cells . Positive_regulation SYT1 TNF 10336463 615456 RAI protein appeared to be located in the nucleus and colocalized with NF-kappaB [p65] that was *activated* by . Positive_regulation SYT1 TNF 10593907 572882 However , Cr(VI) pretreatments prevented *stimulated* interactions between the [p65] subunit of NF-kappaB and the transcriptional cofactor cAMP-responsive element binding protein binding protein ( CBP ) . Positive_regulation SYT1 TNF 10692565 671219 Since these complexes are known to repress NF-kappaB dependent gene transcription , our results delineate a second molecular mechanism , in addition to the recently found block of mediated [p50/p65] *activation* , that may be responsible for the immunosuppresive effects of TCDD . Positive_regulation SYT1 TNF 10843709 700168 Resveratrol also suppressed *induced* phosphorylation and nuclear translocation of the [p65] subunit of NF-kappaB , and NF-kappaB dependent reporter gene transcription . Positive_regulation SYT1 TNF 10938077 737433 Previously , we have shown that *induces* [RelA/p65] phosphorylation at serine 529 and that this inducible phosphorylation increases NF-kappaB transcriptional activity on an exogenously supplied reporter ( ) . Positive_regulation SYT1 TNF 11786478 901315 5. Taken together , these data demonstrate that magnolol inhibits *induced* nuclear translocation of NF-kappa B [p65] and thereby suppresses expression of VCAM-1 , resulting in reduced adhesion of leukocytes . Positive_regulation SYT1 TNF 11827962 928934 Either Tat or *activated* [p65] translocation and binding to an oligonucleotide containing the E-selectin kappaB site 3 sequence . Positive_regulation SYT1 TNF 12368228 1019216 Furthermore , we show for the first time that NAC inhibited *mediated* phosphorylation of [p65] ( ser536 ) , whereas PW had no effect on this phosphorylation . Positive_regulation SYT1 TNF 12442886 1017124 Moreover , DHMEQ inhibited the *induced* nuclear accumulation of [p65] , a component of NF-kappaB . Positive_regulation SYT1 TNF 12444159 1017402 When examined for the mechanism , we found that piceatannol inhibited *induced* IkappaBalpha phosphorylation , p65 phosphorylation , [p65] nuclear translocation , and IkappaBalpha kinase activation , but had no significant effect on IkappaBalpha degradation . Positive_regulation SYT1 TNF 12842894 1134791 induced IKK phosphorylation of NF-kappaB [p65] on serine 536 is *mediated* through the TRAF2 , TRAF5 , and TAK1 signaling pathway . Positive_regulation SYT1 TNF 12851413 1134912 This suppression of NF kappa B is manifested by an inhibition of TNF induced inhibitor of NF kappa B ( IKK ) activity and NF kappa B DNA binding potential but not by blocking *induced* nuclear accumulation of NF kappa [B/p65] . Positive_regulation SYT1 TNF 14600158 1200275 Pretreatment of normal human intestinal lamina propria mononuclear cells ( LPMC ) with transforming growth factor-beta1 ( TGF-beta1 ) resulted in a marked suppression of *induced* NF-kappaB [p65] accumulation in the nucleus , NF-kappaB binding DNA activity , and NF-kappaB dependent gene activation . Positive_regulation SYT1 TNF 14662828 1177604 Furthermore , CIAS1 suppressed *induced* nuclear translocation of endogenous [p65] . Positive_regulation SYT1 TNF 14741380 1203265 Overexpression of RORalpha1 and RORalpha4 also suppressed *stimulated* translocation of p50 and [p65] to the nucleus . Positive_regulation SYT1 TNF 15583752 1345351 AT inhibited the *induced* interaction of NF-kappaB [p65] with p300 , a homologue of cAMP-responsive element binding protein ( CREB) binding protein (CBP ) . Positive_regulation SYT1 TNF 15637292 1381267 These results demonstrate that TSH induces the formation of PKAc/IkappaB complex in FRTL-5 cells and that this PKAc bound with IkappaB plays a critical role in *dependent* activation of [p65] . Positive_regulation SYT1 TNF 15677444 1395380 We identified importin alpha3 and importin alpha4 as the main importin alpha isoforms mediating *stimulated* NF-kappaB [p50/p65] heterodimer translocation into the nucleus . Positive_regulation SYT1 TNF 15971008 1434683 Pre shearing of ECs at HSS significantly inhibited the *induced* [p65] and p50 mRNA expressions and nuclear factor-kappaB (NF-kappaB)-DNA binding activity . Positive_regulation SYT1 TNF 15972682 1424223 The inhibition of eotaxin production by beta ( 2 ) -agonists and glucocorticoids was transcriptional and not due to altered NF-kappaB nuclear translocation or in vitro promoter binding capability , but due to their inhibition of *induced* histone H4 acetylation and [p65] in vivo binding to the promoter . Positive_regulation SYT1 TNF 16253226 1483786 PGG treatment attenuated *induced* nuclear factor-kappaB (NF-kappaB) [p65] translocation in human umbilical vein endothelial cells . Positive_regulation SYT1 TNF 16269157 1525810 AR treatment attenuated *induced* NF-kappaB [p65] translocation in HUVECs in a dose dependent manner . Positive_regulation SYT1 TNF 16272352 1479485 *stimulated* the translocation of [p65] and p50 from the cytosol to the nucleus of human RA synovial fibroblasts , as well as NF-kappaB activation measured by luciferase reporter assay . Positive_regulation SYT1 TNF 16595893 1544727 Western blot revealed that the treatment of Huh 7 cells with pitavastatin at 0.1 microM inhibited the nuclear expression of NF-kappaB [p65] *induced* by . Positive_regulation SYT1 TNF 16624823 1569383 The suppression of NF-kappaB activation correlated with sequential inhibition of the *induced* activation of IkappaBalpha kinase , IkappaBalpha phosphorylation , IkappaBalpha degradation , p65 phosphorylation , [p65] nuclear translocation , and the NF-kappaB dependent reporter gene expression activated by TNF , TNFR1 , TRAF2 , NIK , IKK-beta , and the p65 subunit of NF-kappaB . Positive_regulation SYT1 TNF 16644735 1583264 Mechanistically , our data indicated that , in *response* to , [NFkappaB/p65] phosphorylation and translocation as well as IkappaBalpha phosphorylation and degradation were unchanged , suggesting that Lnk does not modulate NFkappaB activity . Positive_regulation SYT1 TNF 16804400 1579580 Pretreatment of human epithelial HT-29 cells with gliotoxin significantly blocked the I-kappaB degradation and NF-kappaB [p65] nuclear translocation *induced* by or IL-1beta ; Positive_regulation SYT1 TNF 16904979 1601526 induced I kappaB alpha phosphorylation and degradation at 5 and 30 minutes , respectively , and *induced* [P65] phosphorylation . Positive_regulation SYT1 TNF 17202332 1680894 Moreover , guanosine abrogated IFN-gamma induced phosphorylation on Ser ( 727 ) and translocation of STAT-1alpha to the nucleus as well as *induced* IkappaBalpha and NF-kappaB [p65/RelA] subunit phosphorylation , thus inhibiting NF-kappaB induced nuclear translocation . Positive_regulation SYT1 TNF 17475341 1744125 Immunoblot analysis indicated that morphine , fentanyl and beta-FNA each reduced *induced* nuclear translocation of NF-kappaB [p65] . Positive_regulation SYT1 TNF 17617381 1769547 The *induced* nuclear translocation of NF-kappaB [p65] was also delayed , but not inhibited , in the presence of methylglyoxal . Positive_regulation SYT1 TNF 17617381 1769548 *induced* phosphorylation of [p65] was not affected by methylglyoxal . Positive_regulation SYT1 TNF 17675290 1794070 By electrophoretic mobility shift assay analyses , and lipopolysaccharide *induce* strong [p65/p50] and p65/c-Rel heterodimer binding to both NF-kappaB and TF-kappaB probes . Positive_regulation SYT1 TNF 17962452 1815150 Emodin inhibited *induced* NF-kappaB [p65] and JNK activation but did not affect transforming growth factor beta1 induced Smad2/3 signaling . Positive_regulation SYT1 TNF 18202703 1876401 Furthermore , *induced* [p65/RelA] phosphorylation as well as transcriptional activity of nuclear factor-kappaB (NF-kappaB) was significantly downregulated in T6 ( -/- ) 3T3 cells . Positive_regulation SYT1 TNF 18222174 1871084 Pretreatment of EPA inhibited *induced* MMP-9 expression and [p65] phosphorylation . Positive_regulation SYT1 TNF 18222174 1871091 EPA inhibited *induced* [p65] phosphorylation through p38 and Akt inhibition and this inhibition was IKKalpha dependent event . Positive_regulation SYT1 TNF 18772349 2012047 Further , NF-kappaB activation by or p65 overexpression *stimulates* Shh promoter activity and [p65] binds to Shh promoter in vivo . Positive_regulation SYT1 TNF 19201922 2054187 In normal human bronchial epithelial cells , andrographolide blocked *induced* phosphorylation of inhibitory kappaB kinase-beta , and downstream inhibitory kappaB alpha degradation , p65 subunit of NF-kappaB phosphorylation , and [p65] nuclear translocation and DNA binding activity . Positive_regulation SYT1 TNF 19274442 2072831 Pep 3 ( LRENECVS ) which was derived from the hydrophilic region of A1 module in CRD4 remarkably inhibited the binding of TNF-alpha to TNF-R1 , and also reversed *induced* degradation of IkappaB-alpha and nuclear translocation of NF-kappaB [p65] subunit in HeLa cells . Positive_regulation SYT1 TNF 19445900 2115287 Results obtained show that selected purified compounds had a cytotoxic effect on the human leukaemia cell line K562 , inhibited both TNF-alpha induced NF-kappaB-DNA binding as well as *induced* IkappaBalpha degradation and nuclear translocation of [p50/p65] . Positive_regulation SYT1 TNF 19465513 2107385 DMF inhibited *induced* NF-kappaB [p65] phosphorylation , NF-kappaB nuclear entry , and NF-kappaB-DNA complex formation , whereas PDGF-BB appeared not to activate NF-kappaB within 60 min . Positive_regulation SYT1 TNF 1966546 149781 and interleukin-1 (IL-1) *enhanced* the phosphorylation of identical cytosolic 65 kDa protein ( [P65] or l-plastin ) and 74 kDa protein ( P74 ) at serine residues in human peripheral blood mononuclear cells ( PBMC ) . Positive_regulation SYT1 TNF 1966546 149785 These results suggest that *induction* of phosphorylation of [P65] and P74 by and IL-1 is not mediated by PKC and PKA but may be mediated by another protein kinase and result in overlapping of biological activities between TNF and IL-1 . Positive_regulation SYT1 TNF 19734226 2139663 Furthermore , chromatin immunoprecipitation studies detected increased binding of NF-kappaB [p65] and RNA polymerase II to the CXCL8 promoter of asthmatic HASM cells both in the *presence* and absence of stimulation . Positive_regulation SYT1 TNF 19776225 2232020 Moreover , 11 beta-HSD1 inhibitors attenuated *induced* phosphorylation of NF-kappaB [p65] and p38- , JNK- , and ERK1/2-MAPK . Positive_regulation SYT1 TNF 20104512 2272245 A further analysis indicated that EGJ attenuated *induced* nuclear [p65] nuclear factor-kappa B (NF-kappaB) translocation , suggesting that EGJ primarily affects the TNF-alpha induced NF-kappaB signaling pathway . Positive_regulation SYT1 TNF 20333651 2266145 We also showed that *induced* Akt translocation and the formation of an [Akt/p65/p300] complex . Positive_regulation SYT1 TNF 20351055 2273278 ECs treated with GSH and H ( 2 ) O ( 2 ) show increased sulfhydryl modifications of the p65 subunit of nuclear factor kappa-light-chain-enhancer of activated B cells ( NF-kappaB ) , which are responsible for NF-kappaB inactivation , and also a block in *induced* [p65] nuclear translocation and inter-cellular adhesion molecule-1 ( ICAM-1 ) expression . Positive_regulation SYT1 TNF 20966395 2365259 Erg inhibited *dependent* activation of the ICAM-1 promoter , nuclear factor ( NF ) -?B activity , and NF-?B [p65] phosphorylation . Positive_regulation SYT1 TNF 21138840 2384292 Conversely , overexpression of spliced XBP1 attenuated *induced* phosphorylation of IKK , I?Ba , and NF-?B [p65] , accompanied by decreased NF-?B activity and reduced adhesion molecule expression . Positive_regulation SYT1 TNF 21564349 2449412 In the present study , we show by western blotting that 17ß-oestradiol ( E ( 2 ) ) decreases *induced* [NF-?B/p65] and p50 nuclear translocation in primary cultures of anterior pituitary cells from ovariectomised ( OVX ) rats . Positive_regulation SYT1 TNF 21598036 2480891 Therefore , these findings suggest that clasmatodendrosis may be autophagic astroglial death in response to epileptic seizures through *mediated* [p65/RelA-Ser529] phosphorylation . Positive_regulation SYT1 TNF 21767632 2472359 Taken together , these data show that viscolin inhibits *induced* JNK phosphorylation , nuclear translocation of NF-?B [p65] , and ROS generation and thereby suppresses VCAM-1 expression , resulting in reduced adhesion of leukocytes . Positive_regulation SYT1 TNF 22026410 2513650 In addition , 1 and LY294002 blocked *induced* I?B-a degradation and nuclear [p65] protein accumulation , as well as the DNA binding activity of NF-?B . Positive_regulation SYT1 TNF 22231395 2544701 Western blotting was used to assess the expression of both NF-?B regulated gene products and *induced* activation of [p65] , I?Ba , and IKK . Positive_regulation SYT1 TNF 22231395 2544705 In addition to inhibition of NF-?B p65 nuclear translocation , the compound also suppressed *induced* phosphorylation of [p65] and IKK , and the degradation of I?Ba . Positive_regulation SYT1 TNF 22240205 2569325 These findings suggest that impairments of endothelial cell functions via *mediated* [p65-Thr] 485 NF-?B phosphorylation may be involved in SE-induced vasogenic edema . Positive_regulation SYT1 TNF 22616553 2632451 MXF , DXM and the combination of MXF with DXM inhibited *stimulated* p-ERK1/2 and NF-?B [p65] levels by 34 , 40 and 62 % , and 33 , 38 and 64 % , respectively . Positive_regulation SYT1 TNF 22898620 2687668 Treatment of VSMCs with sulforaphane blocked *induced* I?Ba degradation and NF-?B [p65] and GATA6 expression . Positive_regulation SYT1 TNF 23091559 2690705 In addition , we found that dentatin inhibited *induced* nuclear translocation of [p65] , suggesting dentatin as a potential NF-?B inhibitor . Positive_regulation SYT1 TNF 23102662 2703708 Although cordycepin did not block *induced* nuclear translocation of [p65] , high concentration of cordycepin reduced the DNA binding and transcriptional activities of NF-?B . Positive_regulation SYT1 TNF 23729444 2801848 Exogenous GILZ inhibited *induced* NF-?B [p65] DNA binding , although this occurred in the absence of an effect on p65 nuclear translocation , indicating that the mechanism of action of exogenous GILZ in endothelial cells differs from that reported in other cell types . Positive_regulation SYT1 TNF 24134657 2889351 MPA also inhibited *induced* nuclear translocation of NF-?B [p65] . Positive_regulation SYT1 TNF 24316968 2894854 In addition , carnosol inhibited the *induced* phosphorylation of [p-65] and I?B-a , as well as the activation of NF-?B . Positive_regulation SYT1 TNF 24348668 2881118 We investigated whether prunetin significantly affects *induced* MUC5AC mucin gene expression , production , inhibitory kappa B ( I?B ) degradation and nuclear factor kappa B ( NF-?B ) [p65] translocation in human airway epithelial cells . Positive_regulation SYT1 TNF 24534785 2942604 AKF-PD significantly inhibited *induced* expression of interleukin-6 , monocyte chemoattractant protein-1 and interleukin-8 and nuclear translocation of [p65] in HK-2 cells . Positive_regulation SYT1 TNF 7594489 334767 did not *mediate* the translocation of NF-kappa B [p50/p65] induced by triggering of complement receptors . Positive_regulation SYT1 TNF 8051093 267601 Both [p65] transactivation and *induction* of the p53 promoter depended on an intact NF-kappa B site . Positive_regulation SYT1 TNF 8746784 343497 We demonstrated here that *induced* binding of NF kappa B p50 and [p65] to the NF kappa B-like element of the MHC class I promoter termed region I and IFN-gamma induced binding of IRF-1 to the adjacent interferon consensus sequence ( ICS ) . Positive_regulation SYT1 TNF 9452444 484110 p38 and extracellular signal regulated kinase mitogen activated protein kinase pathways are required for nuclear factor-kappaB [p65] transactivation *mediated* by . Positive_regulation SYT1 TNF 9743347 532402 Pretreatment of cells with IL-13 blocked *induced* NF-kappa B activation , nuclear translocation of [p65] subunit , and degradation of I kappa B alpha . Positive_regulation SYT1 TNF 9756499 535743 *dependent* increases in hepatic nuclear factor-kappaB (NF-kappaB) p50 and [p65] expression and DNA binding activity are prevented , whereas IL-6 dependent inductions of hepatic Stat-3 phosphorylation and DNA binding activity occur normally . Positive_regulation SYT1 TNFSF10 16024612 1435239 Analysis of the NF-kappaB activation pathway indicated that unexpectedly *induced* cleavage of [p65] at Asp97 , which was blocked by z-VAD , accounting for all of these findings . Positive_regulation SYT1 TNFSF10 20668316 2298290 Vanillin pretreatment inhibited *induced* phosphorylation of [p65] and transcriptional activity of NF-kappaB . Positive_regulation SYT10 RAB31 17625073 1829500 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT11 RAB31 17625073 1829416 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT12 RAB31 17625073 1829360 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT13 RAB31 17625073 1829304 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT14 RAB31 17625073 1829556 Previous studies indicate that the process requires *dependent* tethering of membranes , SNARE complex assembly , and Ca2+ mediated activation of [synaptotagmin] . Positive_regulation SYT15 RAB31 17625073 1829332 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT16 RAB31 17625073 1829528 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT17 RAB31 17625073 1829584 Previous studies indicate that the process requires *dependent* tethering of membranes , SNARE complex assembly , and Ca2+ mediated activation of [synaptotagmin] . Positive_regulation SYT2 RAB31 17625073 1829128 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT3 RAB31 17625073 1829156 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT4 RAB31 17625073 1829184 Previous studies indicate that the process requires *dependent* tethering of membranes , SNARE complex assembly , and Ca2+ mediated activation of [synaptotagmin] . Positive_regulation SYT5 RAB31 17625073 1829212 Previous studies indicate that the process requires *dependent* tethering of membranes , SNARE complex assembly , and Ca2+ mediated activation of [synaptotagmin] . Positive_regulation SYT6 RAB31 17625073 1829388 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT7 RAB31 17625073 1829240 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT8 ATP5O 16713576 1564925 [Synaptotagmin] *induces* a 4-fold increase in the activity of wild-type p97/VCP ( p97/VCP ( wt ) ) , but not in mutants that showed an ERAD impairment . Positive_regulation SYT8 CA2 10617141 656962 Our findings are consistent with models in which the *triggered* release of [synaptotagmin] precedes vesicle fusion . Positive_regulation SYT8 CA2 12062043 952993 *dependent* [synaptotagmin] binding to SNAP-25 is essential for Ca2+ triggered exocytosis . Positive_regulation SYT8 CA2 12062043 953057 We found that synaptotagmins I and IX associate with SNAP-25 during Ca2+ dependent exocytosis in PC12 cells , and we identified C-terminal amino acids in SNAP-25 ( Asp179 , Asp186 , Asp193 ) that are required for *dependent* [synaptotagmin] binding . Positive_regulation SYT8 CA2 12062043 953109 These results indicate that the *dependent* interaction of [synaptotagmin] with SNAP-25 is essential for the Ca2+ dependent triggering of membrane fusion . Positive_regulation SYT8 CA2 15737991 1396624 For example , Mg2+ is a cofactor for the N-ethylmaleimide-sensitive factor (NSF) ATPase , and the signal from neuronal membrane depolarization is *required* for [synaptotagmin] activation . Positive_regulation SYT8 CA2 16502487 1529058 We investigated a type of *dependent* [synaptotagmin] and Ca2+ signaling in both rat and mouse parotid acinar cells using RT-PCR , microfluorometry , and amylase assay . Positive_regulation SYT8 CA2 17625073 1829421 Previous studies indicate that the process requires Rab3 dependent tethering of membranes , SNARE complex assembly , and mediated *activation* of [synaptotagmin] . Positive_regulation SYT8 CA2 17715396 1806323 Gbetagamma interferes with *dependent* binding of [synaptotagmin] to the soluble N-ethylmaleimide-sensitive factor attachment protein receptor ( SNARE) complex . Positive_regulation SYT8 CA2 17891149 1802516 *dependent* binding of [synaptotagmin] to its own membrane impedes the activation . Positive_regulation SYT8 CA2 7559535 323881 *regulates* the interaction between [synaptotagmin] and syntaxin 1 . Positive_regulation SYT8 CA2 8621455 359597 We report that *causes* [synaptotagmin] to oligomerize , primarily forming dimers , via its second C2 domain . Positive_regulation SYT8 CA2 8621455 359864 In contrast , a separate *dependent* interaction between [synaptotagmin] and syntaxin , a component of the fusion apparatus , occurs with an EC50 value of approximately 100 microM Ca2+ and involves the synergistic action of both C2 domains of synaptotagmin . Positive_regulation SYT8 CA2 9405690 470385 Binding of [synaptotagmin] to the rbA isoform of alpha1A is *dependent* , with maximum affinity at 10-20 microM Ca2+ . Positive_regulation SYT8 GEMIN4 16713576 1564924 [Synaptotagmin] *induces* a 4-fold increase in the ATPase activity of wild-type ( p97/VCP ( wt ) ) , but not in mutants that showed an ERAD impairment . Positive_regulation SYT8 MCOLN1 15737991 1396623 For example , is a cofactor for the N-ethylmaleimide-sensitive factor (NSF) ATPase , and the Ca2+ signal from neuronal membrane depolarization is *required* for [synaptotagmin] activation . Positive_regulation SYT8 RAB10 17625073 1829439 Previous studies indicate that the process requires *dependent* tethering of membranes , SNARE complex assembly , and Ca2+ mediated activation of [synaptotagmin] . Positive_regulation SYT8 RAB12 17625073 1829438 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT8 RAB13 17625073 1829440 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT8 RAB14 17625073 1829427 Previous studies indicate that the process requires *dependent* tethering of membranes , SNARE complex assembly , and Ca2+ mediated activation of [synaptotagmin] . Positive_regulation SYT8 RAB15 17625073 1829434 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT8 RAB17 17625073 1829426 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT8 RAB18 17625073 1829422 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT8 RAB19 17625073 1829432 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT8 RAB20 17625073 1829429 Previous studies indicate that the process requires *dependent* tethering of membranes , SNARE complex assembly , and Ca2+ mediated activation of [synaptotagmin] . Positive_regulation SYT8 RAB21 17625073 1829430 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT8 RAB23 17625073 1829424 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT8 RAB24 17625073 1829441 Previous studies indicate that the process requires *dependent* tethering of membranes , SNARE complex assembly , and Ca2+ mediated activation of [synaptotagmin] . Positive_regulation SYT8 RAB25 17625073 1829428 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT8 RAB26 17625073 1829423 Previous studies indicate that the process requires *dependent* tethering of membranes , SNARE complex assembly , and Ca2+ mediated activation of [synaptotagmin] . Positive_regulation SYT8 RAB28 17625073 1829442 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT8 RAB30 17625073 1829443 Previous studies indicate that the process requires *dependent* tethering of membranes , SNARE complex assembly , and Ca2+ mediated activation of [synaptotagmin] . Positive_regulation SYT8 RAB31 17625073 1829444 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT8 RAB32 17625073 1829445 Previous studies indicate that the process requires *dependent* tethering of membranes , SNARE complex assembly , and Ca2+ mediated activation of [synaptotagmin] . Positive_regulation SYT8 RAB34 17625073 1829425 Previous studies indicate that the process requires *dependent* tethering of membranes , SNARE complex assembly , and Ca2+ mediated activation of [synaptotagmin] . Positive_regulation SYT8 RAB35 17625073 1829446 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT8 RAB36 17625073 1829447 Previous studies indicate that the process requires *dependent* tethering of membranes , SNARE complex assembly , and Ca2+ mediated activation of [synaptotagmin] . Positive_regulation SYT8 RAB37 17625073 1829437 Previous studies indicate that the process requires *dependent* tethering of membranes , SNARE complex assembly , and Ca2+ mediated activation of [synaptotagmin] . Positive_regulation SYT8 RAB38 17625073 1829448 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT8 RAB41 17625073 1829431 Previous studies indicate that the process requires *dependent* tethering of membranes , SNARE complex assembly , and Ca2+ mediated activation of [synaptotagmin] . Positive_regulation SYT8 RAB42 17625073 1829436 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation SYT8 RAB43 17625073 1829433 Previous studies indicate that the process requires *dependent* tethering of membranes , SNARE complex assembly , and Ca2+ mediated activation of [synaptotagmin] . Positive_regulation SYT8 RAB44 17625073 1829435 Previous studies indicate that the process requires *dependent* tethering of membranes , SNARE complex assembly , and Ca2+ mediated activation of [synaptotagmin] . Positive_regulation SYT8 SNAP23 12526776 1048213 Thus , triggering of the fast component of release by Sr ( 2+ ) as a Ca ( 2+ ) agonist involves the formation of [synaptotagmin/phospholipid] complexes , but does not *require* stimulated binding . Positive_regulation SYT8 STX4 12526776 1048214 Thus , triggering of the fast component of release by Sr ( 2+ ) as a Ca ( 2+ ) agonist involves the formation of [synaptotagmin/phospholipid] complexes , but does not *require* stimulated binding . Positive_regulation SYT8 SV2A 20702688 2335502 In synapses , *regulates* the expression and trafficking of the calcium sensor protein [synaptotagmin] , an action consistent with the reduced calcium mediated exocytosis observed in neurons lacking SV2 . Positive_regulation SYT8 VCP 16713576 1564923 [Synaptotagmin] *induces* a 4-fold increase in the ATPase activity of wild-type ( p97/VCP ( wt ) ) , but not in mutants that showed an ERAD impairment . Positive_regulation SYT9 RAB31 17625073 1829472 Previous studies indicate that the process requires dependent tethering of membranes , SNARE complex assembly , and Ca2+ mediated *activation* of [synaptotagmin] . Positive_regulation TAB1 IL1B 17559674 1792014 Quantitative PCR showed that [TAK1] deficiency significantly decreased *induced* MMP3 gene expression and IL-6 protein expression . Positive_regulation TAB1 IL1B 19232515 2050507 FBXW5 , an F-box family protein , was identified as a previously unknown component of the *induced* [TAK1 complex] . Positive_regulation TAB1 IL1B 19232515 2050515 Overexpression of FBXW5 inhibited *induced* activation of JNK/p38 MAPKs and NF-kappaB as well as phosphorylation of [TAK1] on Thr187 . Positive_regulation TAB1 MAP2K6 16845370 1592247 Furthermore , YopP in synergy with a previously described negative regulatory feedback loop inhibits TAK1 by *mediated* [TAB1] phosphorylation . Positive_regulation TAB1 RCAN1 19716405 2158159 also *stimulated* IL-1R mediated signaling pathways , [TAK1] activation , NF-kappaB transactivation , and IL-8 production , all downstream consequences of IL-1R activation . Positive_regulation TAB1 TLR7 21232528 2392251 Stimulation with LPS also triggered the modification ( phosphorylation and ubiquitination ) and eventually the proteasomal degradation of membrane associated interleukin (IL)-1 receptor associated serine/threonine kinase 1 ( IRAK-1 ) , an essential signaling component to mediated [TAK-1] *activation* . Positive_regulation TAB1 TLR7 24277938 2898484 Upon *stimulation* with ligands , S6K1 deficiency causes a marked increase in [TAK1] kinase activity that in turn induces a substantial enhancement of NF-?B dependent gene expression , indicating that S6K1 is negatively involved in the TLR signaling pathway by the inhibition of TAK1 activity . Positive_regulation TAB1 TNF 10187861 603060 Furthermore , activated endogenous TAK1 , and the kinase negative [TAK1] *acted* as a dominant negative inhibitor against tumor necrosis factor-alpha induced NF-kappaB activation . Positive_regulation TAB1 TNF 14633987 1170870 Cotransfection of siRNAs directed against both TAB2 and TAB3 inhibit both IL-1- and *induced* activation of [TAK1] and NF-kappaB . Positive_regulation TAB1 TNF 15590691 1368803 Immunoblotting with a novel phospho-TAK1 antibody revealed that significantly *induced* the phosphorylation of endogenous [TAK1] at Thr-187 , and subsequently the phosphorylated forms of TAK1 rapidly disappeared . Positive_regulation TAB1 TNF 15590691 1368817 Furthermore , SB203580 and p38alpha small interfering RNA enhanced *induced* Thr-187 phosphorylation as well as [TAK1] kinase activity , indicating that the phosphorylation is affected by p38alpha/TAB1/TAB2 mediated feedback control of TAK1 . Positive_regulation TAB1 TNF 15837794 1432559 We identified 518 genes that were regulated by TNF in both TAK1K63W expressing cells and control cells , 37 genes *induced* by only when [TAK1K63W] was present , and 48 TNF induced genes that were suppressed by TAK1K63W . Positive_regulation TAB1 TNF 16385569 1533418 Activation of endogenous [TAK1] , a mitogen activated protein kinase ( MAP3K ) regulating the JNK and p38 MAPK pathways , was *induced* rapidly by , and co-transfection of TAK1 with its activator protein TAB1 stimulated activation of JNK and p38 MAPKs , which led to activation of the transcription factor AP-1 . Positive_regulation TAB1 TNF 17110449 1732114 Recent studies indicate that induced IKK activation *requires* activation of [TAK1] , and we indeed found that celastrol inhibited the TAK1 induced NF-kappaB activation . Positive_regulation TAB1 TNF 17387141 1741648 Fisetin also inhibited *induced* [TAK1] and receptor interacting protein activation , events that lie upstream of IKK activation . Positive_regulation TAB1 TNF 17897957 1824016 *increased* the activity of transforming growth factor-beta activating kinase-1 ( [TAK1] ) . Positive_regulation TAB1 TNF 19393267 2094946 Cross interference with *induced* [TAK1] activation via EGFR mediated p38 phosphorylation of TAK1 binding protein 1 . Positive_regulation TAB1 TNF 19393267 2094954 The inducible phosphorylation of TAB1 interfered with a response of EGF treated cells to *induced* [TAK1] activation , which led to the reduction of NF-kappaB activation . Positive_regulation TAB1 TNF 19393267 2094956 Collectively , these results demonstrated that EGFR activation interfered with *induced* [TAK1] activation via p38 mediated phosphorylation of TAB1 . Positive_regulation TAB1 TNF 19410630 2089686 *augmented* the phosphorylation of [TAK1] . Positive_regulation TAB2 ID1 20697353 2335476 *enhances* RING1b E3 [ubiquitin ligase] activity through the Mel-18/Bmi-1 polycomb group complex . Positive_regulation TAB3 TNF 14766965 1212043 Furthermore , the *activation* of NF-kappaB by [TAB3] was blocked by the NF-kappaB inhibitor , SN50 , and by expression of dominant negative forms of alpha associated factor 6 and transforming growth factor beta activated kinase . Positive_regulation TAC1 IL1B 9785036 540869 Collectively , these results demonstrate that , generated centrally in response to inflammation , *upregulates* the opioid and [tachykinin] peptides in the hypothalamus . Positive_regulation TAC1 TNF 2160321 133272 Studies of cytokine receptor expression indicated that OKT3 plus IL-2 plus *caused* an earlier up-regulation of [the IL-2 receptor beta chain (Tac)] and higher TNF receptor expression by day 6 compared to 100 units/ml IL-2 alone . Positive_regulation TAC1 TNF 21904641 2478343 Whereas the [TAC] and lactate levels did not change significantly , but CK and *increased* significantly in the supplement group . Positive_regulation TAC3 IL1B 9785036 540870 Collectively , these results demonstrate that , generated centrally in response to inflammation , *upregulates* the opioid and [tachykinin] peptides in the hypothalamus . Positive_regulation TAC3 TNF 2160321 133274 Studies of cytokine receptor expression indicated that OKT3 plus IL-2 plus *caused* an earlier up-regulation of [the IL-2 receptor beta chain (Tac)] and higher TNF receptor expression by day 6 compared to 100 units/ml IL-2 alone . Positive_regulation TAC3 TNF 21904641 2478344 Whereas the [TAC] and lactate levels did not change significantly , but CK and *increased* significantly in the supplement group . Positive_regulation TAC4 IL1B 9785036 540871 Collectively , these results demonstrate that , generated centrally in response to inflammation , *upregulates* the opioid and [tachykinin] peptides in the hypothalamus . Positive_regulation TAC4 TNF 2160321 133277 Studies of cytokine receptor expression indicated that OKT3 plus IL-2 plus *caused* an earlier up-regulation of [the IL-2 receptor beta chain (Tac)] and higher TNF receptor expression by day 6 compared to 100 units/ml IL-2 alone . Positive_regulation TAC4 TNF 21904641 2478348 Whereas the [TAC] and lactate levels did not change significantly , but CK and *increased* significantly in the supplement group . Positive_regulation TACC2 EPHB2 24409148 2900630 Once activated , can *trigger* [chromatin remodeling] and induce gene expression that permits long-term cellular alterations and drug induced morphological and behavioral changes . Positive_regulation TACC2 FOXA1 19687299 2138970 This *mediated* [chromatin remodeling] does not induce MMTV transcription , as opposed to that of the GR . Positive_regulation TACC2 MAP2K6 17077328 1693079 In the *presence* of inhibitors , however , retinoid induced [chromatin remodeling] , target-gene transcription , and granulocytic differentiation are strikingly inhibited and apoptosis induction becomes independent of death inducing ligand/receptor pairs ; Positive_regulation TACC2 STAT4 14660657 1202204 is *required* for interleukin-12 induced [chromatin remodeling] of the CD25 locus . Positive_regulation TACC2 STAT4 14660657 1202287 In this report , we utilize chromatin immunoprecipitation assays to analyze IL-12 stimulated and *dependent* changes in [chromatin remodeling] of the CD25 gene . Positive_regulation TACC2 TLR7 20974955 2344099 Our results suggest that IFN-? overcomes endotoxin tolerance by facilitating *induced* [chromatin remodeling] to allow expression of proinflammatory genes . Positive_regulation TACC3 EPHB2 24409148 2900631 Once activated , can *trigger* [chromatin remodeling] and induce gene expression that permits long-term cellular alterations and drug induced morphological and behavioral changes . Positive_regulation TACC3 FOXA1 19687299 2138971 This *mediated* [chromatin remodeling] does not induce MMTV transcription , as opposed to that of the GR . Positive_regulation TACC3 MAP2K6 17077328 1693086 In the *presence* of inhibitors , however , retinoid induced [chromatin remodeling] , target-gene transcription , and granulocytic differentiation are strikingly inhibited and apoptosis induction becomes independent of death inducing ligand/receptor pairs ; Positive_regulation TACC3 STAT4 14660657 1202232 is *required* for interleukin-12 induced [chromatin remodeling] of the CD25 locus . Positive_regulation TACC3 STAT4 14660657 1202288 In this report , we utilize chromatin immunoprecipitation assays to analyze IL-12 stimulated and *dependent* changes in [chromatin remodeling] of the CD25 gene . Positive_regulation TACC3 TLR7 20974955 2344109 Our results suggest that IFN-? overcomes endotoxin tolerance by facilitating *induced* [chromatin remodeling] to allow expression of proinflammatory genes . Positive_regulation TACR1 EPHB2 18713853 1955636 Full-length [NK1R] *activation* of was rapid ( peak within 1-2 min ) , whereas truncated NK1R mediated activation was slower ( peak at 20-30 min ) . Positive_regulation TACR1 IL1B 12594338 1064336 To further substantiate that the observed NF-kappa B-dependent *induction* of the human [NK-1R] gene is regulated via a transcriptional event through this NF-kappa B site on the NK-1R gene promoter , we transfected THP-1 cells with a luciferase promoter-reporter construct containing the 5 ' promoter region of the human NK-1R gene . Positive_regulation TACR1 IL1B 15390113 1304800 *upregulates* functional expression of [neurokinin-1 receptor (NK-1R)] via NF-kappaB in astrocytes . Positive_regulation TACR1 IL1B 15390113 1304801 IL-1beta treatment of U87 MG cells and primary rat astrocytes led to an increase in cytosolic Ca ( 2+ ) in response to SP stimulation , indicating that *induced* [NK-1R] is functional . Positive_regulation TACR1 IL1B 15390113 1304802 Caffeic acid phenethyl ester ( CAPE ) , a specific inhibitor of NF-kappaB activation , not only abrogated IL-1beta induced NF-kappaB promoter activation , but also blocked *mediated* induction of [NK-1R] gene expression . Positive_regulation TAF1 TNF 12192035 980702 Here we report that even though NF-kappaB interacts directly with TAF(II)s , induction of NF-kappaB by does not *enhance* [TFIID] recruitment and preinitiation complex formation on some NF-kappaB-responsive promoters . Positive_regulation TAF1 TNF 16386180 1494188 Cytokines are the direct mediators for multiple organ failure (MOF) , and [MOF] is *triggered* by and a cascade of cytokine release , with a prolonged high-expression of IL-6 . Positive_regulation TAF10 TNF 12192035 980726 Here we report that even though NF-kappaB interacts directly with TAF(II)s , induction of NF-kappaB by does not *enhance* [TFIID] recruitment and preinitiation complex formation on some NF-kappaB-responsive promoters . Positive_regulation TAF11 TNF 12192035 980730 Here we report that even though NF-kappaB interacts directly with TAF(II)s , induction of NF-kappaB by does not *enhance* [TFIID] recruitment and preinitiation complex formation on some NF-kappaB-responsive promoters . Positive_regulation TAF12 TNF 12192035 980734 Here we report that even though NF-kappaB interacts directly with TAF(II)s , induction of NF-kappaB by does not *enhance* [TFIID] recruitment and preinitiation complex formation on some NF-kappaB-responsive promoters . Positive_regulation TAF13 TNF 12192035 980738 Here we report that even though NF-kappaB interacts directly with TAF(II)s , induction of NF-kappaB by does not *enhance* [TFIID] recruitment and preinitiation complex formation on some NF-kappaB-responsive promoters . Positive_regulation TAF15 TNF 12192035 980742 Here we report that even though NF-kappaB interacts directly with TAF(II)s , induction of NF-kappaB by does not *enhance* [TFIID] recruitment and preinitiation complex formation on some NF-kappaB-responsive promoters . Positive_regulation TAF4 TNF 12192035 980706 Here we report that even though NF-kappaB interacts directly with TAF(II)s , induction of NF-kappaB by does not *enhance* [TFIID] recruitment and preinitiation complex formation on some NF-kappaB-responsive promoters . Positive_regulation TAF5 TNF 12192035 980710 Here we report that even though NF-kappaB interacts directly with TAF(II)s , induction of NF-kappaB by does not *enhance* [TFIID] recruitment and preinitiation complex formation on some NF-kappaB-responsive promoters . Positive_regulation TAF6 TNF 12192035 980714 Here we report that even though NF-kappaB interacts directly with TAF(II)s , induction of NF-kappaB by does not *enhance* [TFIID] recruitment and preinitiation complex formation on some NF-kappaB-responsive promoters . Positive_regulation TAF6 TNF 16386180 1494189 Cytokines are the direct mediators for multiple organ failure (MOF) , and [MOF] is *triggered* by and a cascade of cytokine release , with a prolonged high-expression of IL-6 . Positive_regulation TAF7 TNF 12192035 980718 Here we report that even though NF-kappaB interacts directly with TAF(II)s , induction of NF-kappaB by does not *enhance* [TFIID] recruitment and preinitiation complex formation on some NF-kappaB-responsive promoters . Positive_regulation TAF9 TNF 12192035 980722 Here we report that even though NF-kappaB interacts directly with TAF(II)s , induction of NF-kappaB by does not *enhance* [TFIID] recruitment and preinitiation complex formation on some NF-kappaB-responsive promoters . Positive_regulation TAF9 TNF 16386180 1494190 Cytokines are the direct mediators for multiple organ failure (MOF) , and [MOF] is *triggered* by and a cascade of cytokine release , with a prolonged high-expression of IL-6 . Positive_regulation TANK TNF 10346818 616675 also *enhances* the binding of native [TRAF2] to MEKK1 and stimulates the kinase activity of the latter . Positive_regulation TANK TNF 12411493 1010842 and actinomycin D treatment *results* in accelerated [TRAF2] degradation in wild-type mouse embryo fibroblasts ( MEFs ) , as compared with Siah2 ( -/- ) cells . Positive_regulation TANK TNF 14713952 1202649 Inhibition of Ubc13 expression by RNAi resulted in inhibition of *induced* [TRAF2] translocation and impaired activation of JNK but not of IKK or p38 . Positive_regulation TANK TNF 15115707 1279375 Thus delta-PKC and PI 3-kinase are positive regulators of *mediated* association of [TRAF2] and RIP with TNFR-1 . Positive_regulation TANK TNF 15861135 1404148 *induced* [c-IAP1/TRAF2] complex translocation to a Ubc6 containing compartment and TRAF2 ubiquitination . Positive_regulation TANK TNF 15861135 1404154 Furthermore , Ubc6 co-localized with translocated TRAF2/c-IAP1 in the ER-associated compartment in vivo , and a catalytically inactive Ubc6 mutant inhibited *induced* , TNF-R2 dependent [TRAF2] degradation . Positive_regulation TANK TNF 16636664 1611883 Conversely , silencing of GSTP1-1 expression through RNA interference ( RNAi ) resulted in increase of *dependent* [TRAF2-ASK1] association followed by hyper-activation of ASK1 and JNK . Positive_regulation TANK TNF 17389591 1735581 Our results demonstrate that RIP1 mediated AIP1 phosphorylation at the 14-3-3 binding site Ser-604 is essential for *induced* [TRAF2-RIP1-AIP1-ASK1] complex formation and for the activation of ASK1-JNK/p38 apoptotic signaling . Positive_regulation TANK TNF 20333651 2266133 Furthermore , *induced* TNFR1 and [TRAF2] complex formation was revealed by immunoprecipitation using an anti-TNFR1 Ab followed by Western blot analysis against an anti-TRAF2 or anti-TNFR1 Ab . Positive_regulation TANK TNF 21119000 2372292 Tumor necrosis factor a (TNF-a) receptor associated factor 2 ( [TRAF2] ) regulates activation of the c-Jun N-terminal kinase (JNK)/c-Jun and the inhibitor of ?B kinase ( IKK ) /nuclear factor ?B ( NF-?B ) signaling cascades in *response* to stimulation . Positive_regulation TANK TNF 21119000 2372294 Here we report that and oxidative stress both *induce* [TRAF2] phosphorylation at serines 11 and 55 and that this dual phosphorylation promotes the prolonged phase of IKK activation while inhibiting the prolonged phase of JNK activation . Positive_regulation TANK TNF 24378531 2911766 We find that in these cells *induces* [TRAF2] degradation , and this is blocked in TNFR2 ( -/- ) macrophages . Positive_regulation TANK TNF 24502696 2914081 *stimulated* TNFR1 , [TRAF2] , and c-Src complex formation was revealed by immunoprecipitation and Western blot . Positive_regulation TAOK1 STK39 18083840 1837212 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation TAP1 TNF 15240699 1270379 In macrophages from STAT-1 knockout mice , neither LPS nor *induced* the expression of [Tap1] or Lmp2 . Positive_regulation TAP1 TNF 15240699 1270381 These results show that LPS and *regulate* the induction of [Tap1] and Lmp2 through STAT1 , but use distinct areas of the promoter . Positive_regulation TAP1 TNF 8617938 353921 Two overlapping IFN consensus sequences contribute to the constitutive and *induced* expression of [TAP1] but are not necessary for the IFN-gamma response . Positive_regulation TAPBP SYNM 23657147 2795981 It has been found that reasoning about internal mental states is associated with *activation* of the and deactivation of the [task positive network (TPN)] ; Positive_regulation TARDBP CAPN8 23250437 2708754 A role for *dependent* cleavage of [TDP-43] in amyotrophic lateral sclerosis pathology . Positive_regulation TARDBP CAPN8 23250437 2708810 Additional demonstration of calpain dependent TDP43 fragments in the spinal cord and brain of amyotrophic lateral sclerosis patients , and high vulnerability of amyotrophic lateral sclerosis linked mutant TDP43 to cleavage by calpain support the crucial role of the *dependent* cleavage of [TDP43] in the amyotrophic lateral sclerosis pathology . Positive_regulation TARDBP EPHB2 21819629 2472846 In contrast , or p38 inhibition *prevented* formation of both [TDP-43] and HuR positive SGs . Positive_regulation TAT EPHB2 11409852 826363 In bovine aortic endothelial cells , [GST-Tat] and the 165 amino acid VEGF isoform ( VEGF165 ) *induce* transient ( 1/2 ) phosphorylation with similar potency and kinetics . Positive_regulation TAT EPHB2 11409852 826368 Accordingly , [GST-Tat] *induces* ( 1/2 ) phosphorylation in KDR transfected porcine aortic endothelial cells but not in parental cells . Positive_regulation TAT EPHB2 16436505 1540506 In addition , we demonstrated that [Tat] activation of Ras , but not of Rac , *induces* phosphorylation . Positive_regulation TAT F3 11156884 780658 also *led* to a rise in [TAT] complexes in plasma , again reflecting thrombin formation . Positive_regulation TAT FAS 9268734 450086 Reverse transcriptase-PCR further demonstrated that [Tat] *induced* expression in B cells at the mRNA level . Positive_regulation TAT IFI27 19720293 2133719 Up-regulation of ( kip1 ) *resulted* in increased retention of [ ( 111 ) In ] -anti-p27 ( kip1 ) [-tat] in cells treated with trastuzumab . Positive_regulation TAT PLAU 9143604 428651 The *inducing* activity of [Tat] depends upon specific biological and structural features of the Tat protein that are distinct from those responsible for its LTR-CAT transactivating activity , suggesting distinct mechanisms of induction for the two biological responses . Positive_regulation TAT TNF 1279199 202968 As TNF can increase the production of IL-1 and IL-6 and these inflammatory cytokines all enhance HIV-1 gene expression and affect the immune , vascular , and central nervous systems , the *activation* of by [Tat] may be part of a complex pathway in which HIV-1 uses viral products and host factors to increase its own expression and infectivity and to induce disease . Positive_regulation TAT TNF 14708348 1181043 [ HIV-1 [Tat] *induces* production by human monocytes : involvement of calcium and PKC pathways ] . Positive_regulation TAT TNF 16828290 1600179 Inhibition of signaling *prevents* human immunodeficiency virus-1 protein [Tat] and methamphetamine interaction . Positive_regulation TAT TNF 16828290 1600180 The present study examined whether *mediates* the interaction between [Tat] and MA . Positive_regulation TAT TNF 20686703 2299248 Moreover , because Tat activates both RelB and TNFalpha in microglia , and because [Tat] *induces* inflammatory synthesis via NF-kappaB , we posit that RelB serves as a cryoprotective , anti-inflammatory , counter-regulatory mechanism for pathogenic NF-kappaB activation . Positive_regulation TAT TNF 8806505 382310 Since TNF is increased in HIV-1 infected individuals and can activate HIV-1 gene expression or rescue Tat-defective HIV-1 proviruses , *activation* of by [Tat] may be part of a complex pathway in which HIV-1 uses its own expression to increase infectivity and to induce disease . Positive_regulation TAT TNF 9278385 451303 We examined the possibility that HIV protein [Tat] , which is released extracellularly from infected cells , may *induce* the production of . Positive_regulation TAT TNFSF10 12767990 1094504 secretion was *induced* by [Tat] and by a cysteine-rich peptide of Tat but not by sulfhydryl modified Tat toxoid . Positive_regulation TAX1BP1 TNF 21765415 2467107 The kinase IKKa , but not IKKß , was required for phosphorylation of TAX1BP1 and directly phosphorylated [TAX1BP1] in *response* to stimulation with or interleukin 1 (IL-1) . Positive_regulation TAZ EPHB2 24125755 2889231 FGF2 induced TAZ expression was stimulated by ERK ( extracellular signal regulated kinase ) activation and the inhibition of *blocked* [TAZ] expression . Positive_regulation TBCA EPHB2 19368817 2058757 Formalin- , [CFA-] and saline-injections *induced* an increase in in the LC . Positive_regulation TBCA F2R 21241677 2397859 Treatment with the selective PAR-1 agonist , TRAP ( SFLLRN ) caused the formation of CFAs , suggesting that [CFA] formation *involved* signaling . Positive_regulation TBCA TNF 12663680 1074594 QS21 and [CFA] *induced* significant IFN-gamma , IL-4 and expression , whereas alum induced primarily IL-4 production . Positive_regulation TBCC TNF 3143710 100976 Short-term treatment of bone marrow in suspension culture for 2 hr did not affect the subsequent colony formation , suggesting that *had* an antiproliferative rather than a direct toxic effect on normal [GM-CFC] . Positive_regulation TBCE ARSA 3679245 80861 It is highly probable that the dog is not a predictive model for man with regard to [KCS] *induction* by sulphasalazine or its metabolite <5-ASA> . Positive_regulation TBCE CD14 12515659 1027849 To explore the effect of LPS on the expression of and the *activation* of [Kupffer cells (KCs)] . Positive_regulation TBCE TNF 12127824 966192 derived from activated intermediate or large KCs may *activate* small [KCs] and the latter may be recruited to other organs , such as lungs and kidneys , and produce a large amount of IL-6 , leading to multiple organ failure . Positive_regulation TBCE TNFSF10 15137068 1246132 The impact of low-dose ultraviolet light ( UV-light ) on apoptotic susceptibility of [keratinocytes (KCs)] *induced* by is unclear . Positive_regulation TBK1 TLR7 21949249 2492574 Here we show that [TBK1] and IKKe are also *activated* by ligands that signal via MyD88 . Positive_regulation TBL1X CCND1 21901538 2521945 We also found that when down regulation of p65 , the expression of and Bc1-2 decreased , and the expression of [SMRT] *increased* in vitro and vivo . Positive_regulation TBL1X INPP4B 21224358 2379442 Optimal induction of by an androgen receptor *required* the expression of the transcriptional coactivator [NCoR] . Positive_regulation TBL1X TLR7 21849441 2486187 Treatment with PPAR? and LXR ligands , but not GR ligands , prevented this *induced* clearance of [NCoR] from the LTR . Positive_regulation TBL1X TNF 21189284 2386027 alpha stimulation *triggered* the formation of an NF-?B and [TBL1] complex and subsequent target gene promoter binding . Positive_regulation TBL1XR1 CCND1 21901538 2521951 We also found that when down regulation of p65 , the expression of and Bc1-2 decreased , and the expression of [SMRT] *increased* in vitro and vivo . Positive_regulation TBL1XR1 IL1B 3260876 95966 In the presence of low concentrations of LH or in its absence markedly *stimulates* the production of C19-steroids ( testosterone and androstenedione ) and [C21-steroids] ( progesterone , 17 alpha-hydroxyprogesterone , 20 alpha-hydroxypregn-4-en-3-one ) . Positive_regulation TBL1XR1 INPP4B 21224358 2379446 Optimal induction of by an androgen receptor *required* the expression of the transcriptional coactivator [NCoR] . Positive_regulation TBL1XR1 TLR7 21849441 2486207 Treatment with PPAR? and LXR ligands , but not GR ligands , prevented this *induced* clearance of [NCoR] from the LTR . Positive_regulation TBP EPHB2 9716183 527877 These observations suggest that *mediated* phosphorylation of [TBP] occurs during the PMA induced differentiation of U937 cells and the stimulation of the G0-G1 transition in fibroblasts and could play a role in the regulation of TBP protein interactions and thus regulate gene transcription during these two processes . Positive_regulation TBP MAP2K6 11454854 850633 More importantly , expression of a constitutive active ( Glu ) resulted in the phosphorylation of a His-TBP fusion protein and *increased* direct interaction of [TBP] with c-Jun . Positive_regulation TBP TNF 12192035 980746 Here we report that even though NF-kappaB interacts directly with TAF(II)s , induction of NF-kappaB by does not *enhance* [TFIID] recruitment and preinitiation complex formation on some NF-kappaB-responsive promoters . Positive_regulation TCEA1 C1QTNF1 9002605 404751 The results of the present work support the possible *role* of in GA-induced corolla and stem [elongation] . Positive_regulation TCEA1 EDN2 19393623 2075066 Thus , *induces* cortical neurite [elongation] through the endothelin A receptor by a mechanism dependent on JNK . Positive_regulation TCEA1 ELOVL4 17304340 1699082 Furthermore , we suggest that is likely *involved* in the [elongation] of C26 and longer fatty acids . Positive_regulation TCEA1 EPHB2 15067199 1231865 Taken together , the results demonstrate the functional *role* for and p23 in the neurite [elongation] activity of FK506 and reveal a novel signal transduction pathway involving p23 activation of ERK . Positive_regulation TCEA1 EPHB2 18676449 1955187 The splice variants of UBF differentially regulate RNA polymerase I transcription [elongation] in *response* to phosphorylation . Positive_regulation TCEA1 FAS 12687369 1078777 Six- and 20-h incubations were studied , and membrane fatty acids were monitored as internal controls for *mediated* [elongation] . Positive_regulation TCEA1 FUT4 7696863 288006 The formation of these extended glycolipids is compatible with the concept that in the *presence* of reduced secretor activity , increased [elongation] of the precursor chain occurs , which supports the postulate that fucosylation of the precursor prevents or at least markedly reduces chain elongation . Positive_regulation TCEA1 FUT4 7701811 288395 We also show that in the *presence* of reduced activity , increased [elongation] of the precursor chain occurs , which allows us to postulate that fucosylation of the precursor prevents or at least markedly reduces chain elongation . Positive_regulation TCEA1 GPR115 20226789 2265641 Stimulation of results in uniform cell enlargement in all directions with an increase in skeletal alpha-actin ( alpha-SKA ) gene expression , while stimulation of gp130 receptor by interleukin-6 (IL-6) related cytokines *induces* longitudinal [elongation] with no increase in alpha-SKA gene expression . Positive_regulation TCEA1 GPR132 20226789 2265630 Stimulation of results in uniform cell enlargement in all directions with an increase in skeletal alpha-actin ( alpha-SKA ) gene expression , while stimulation of gp130 receptor by interleukin-6 (IL-6) related cytokines *induces* longitudinal [elongation] with no increase in alpha-SKA gene expression . Positive_regulation TCEA1 GPR87 20226789 2265710 Stimulation of results in uniform cell enlargement in all directions with an increase in skeletal alpha-actin ( alpha-SKA ) gene expression , while stimulation of gp130 receptor by interleukin-6 (IL-6) related cytokines *induces* longitudinal [elongation] with no increase in alpha-SKA gene expression . Positive_regulation TCEA1 IGFBP1 19497977 2120636 These studies reveal that is a common endometrial marker of conceptus elongation in sheep and cattle and most likely *regulates* conceptus [elongation] by stimulating migration and attachment of the trophectoderm . Positive_regulation TCEA1 ITGAL 22711877 2621435 Experiments with knockout mice and blocking antibodies reveal that the uropod [elongation] and microparticle formation are the *result* of mediated adhesion and VLA-3 mediated cell migration through the vascular basement membrane . Positive_regulation TCEA1 MAP2K6 20869211 2337200 Overexpression of the constitutive active form of *resulted* in significant [elongation] of dendrites in the melanoma cell line SK-mel-24 . Positive_regulation TCEA1 NT5E 15926911 1414195 A reduced amount of BDNF , but not , is *sufficient* to promote the [elongation] of regenerating axons in the PNS . Positive_regulation TCEA1 PCDH19 18171927 1855781 and TAF1 *regulate* retinal axon initiation and [elongation] in vivo . Positive_regulation TCEA1 PCDH8 18171927 1855786 and TAF1 *regulate* retinal axon initiation and [elongation] in vivo . Positive_regulation TCEA1 SRGN 20032306 2205150 When introduced in neurons , is distributed in the plasma membrane and *induces* filopodia as well as axon [elongation] and growth . Positive_regulation TCEA1 TMOD1 18984629 1989787 Thus , we propose a model in which and enhancers of actin dynamics synergistically *regulate* [elongation] and shortening of actin filaments at the pointed end . Positive_regulation TCEA1 TNF 15569261 1343915 In the *presence* of , A2B AR stimulation in vitro induced the [elongation] of astrocytic processes , a typical morphological hallmark of in vivo reactive astrogliosis . Positive_regulation TCEA1 TNF 16307187 1486477 Gradual nerve [elongation] by limb lengthening *induces* production of in Schwann cells . Positive_regulation TCEA1 TNF 17071594 1637687 Mast cell derived can *promote* nerve fiber [elongation] in the skin during contact hypersensitivity in mice . Positive_regulation TCEA1 TNF 17071594 1637689 Using genetically mast cell-deficient c-kit mutant mice selectively repaired of their dermal mast cell deficiency with either wild-type or tumor necrosis factor (TNF)-deficient mast cells , we found that mast cells , and mast cell derived , significantly *contributed* to the [elongation] of epidermal and dermal PGP 9.5+ nerves and dermal CGRP+ nerves , as well as to the inflammation observed at sites of contact hypersensitivity in response to oxazolone . Positive_regulation TCEA1 TNF 17071594 1637691 These observations show that mast cells , and mast cell derived , can *promote* the [elongation] of cutaneous nerve fibers during contact hypersensitivity in the mouse . Positive_regulation TCEA1 TNF 17476691 1772280 subsequently *caused* a progressive increase in permeability and in stress fiber reorganization , cell [elongation] , and intercellular gap formation over 8-24 h. Consistent with the increased permeability , Occludin and JAM-A were removed from tight junctions and ZO-1 was partially redistributed . Positive_regulation TCEA1 TNF 23116662 2717431 and TGF-ß synergistically *stimulate* [elongation] of human endothelial cells without transdifferentiation to smooth muscle cell phenotype . Positive_regulation TCEA1 TNF 7690970 228702 The activity of TNF-p140trk chimeras was completely blocked by the tyrosine kinase inhibitor K252a , and was unable to *induce* neurite [elongation] in PC12 cells transfected with a tyrosine kinase-defective chimeric receptor . Positive_regulation TCEA1 TP63 15863843 1401301 From these results , we suggest that may be *involved* in the early stage of the remodeling process of the psoriatic epidermis as well as in the [elongation] of the rete ridges . Positive_regulation TCEAL1 CCND1 12572356 1029568 Western blot analysis showed tea polyphenols and tea pigments significantly inhibited the expression of protein and *induced* higher expression of [P21WAFI/CIPI] protein . Positive_regulation TCEAL1 CCND1 16711003 1564708 The expression of was decreased and [P21] *increased* significantly in ciglitazone treated group as compared with control group . Positive_regulation TCEAL1 CCND1 19396459 2271867 Our studies from pancreatic cancer cell lines indicate that targeted inhibition of hedgehog signaling by Smo signaling inhibitor KAAD-cyclopamine causes hedgehog target gene expression ( Gli1 ) suppression , *induces* [P21] expression and G1 cell population , and reduced expression of and IGF2 . Positive_regulation TCEAL1 EPHB2 19538337 2103591 Taken together , these results suggest that melatonin exerts the inhibitory effect of the proliferation of RA-FLSs through the activation of [P21] and P27 *mediated* by . Positive_regulation TCEAL1 IFI27 20216467 2319580 Several exercise mediated responses were found to occur independent of condition : 1 ) muscle [ DNA ] increased at 6 h ( +40 % , P < 0.05 ) , 2 ) CDK4 expression increased at 6 h ( +86 % , P < 0.05 ) , 3 ) MYOD expression increased at 6 h ( +98 % , P < 0.05 ) , 4 ) ( KIP1 ) expression decreased at 2 h ( j35 % , P < 0.05 ) and 6 h ( -59 % , P < 0.001 ) , and 5 ) [P21] ( CIP1 ) expression substantially *increased* 2 and 6 h postexercise ( +1.250 % and +4.670 % , respectively , P < 0.001 ) . Positive_regulation TCF12 ADRB2 15024018 1243836 To identify the mechanism responsible for this effect , we determined whether CD86 and/or stimulation *regulated* [transcription factor] expression and binding to the 3'-IgH enhancer in vitro and in vivo . Positive_regulation TCF12 AXIN2 11809808 906679 [Wnt/beta-catenin/Tcf] signaling *induces* the transcription of , a negative regulator of the signaling pathway . Positive_regulation TCF12 CCND1 14706452 1196348 The strong binding of E2F1 and NFkappaB is especially noteworthy , because the former [transcription factor] is *regulated* by , a downstream target of beta-catenin/TCF/LEF signaling , whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways . Positive_regulation TCF12 CCND1 15893541 1407587 The increased protein level was *induced* through activation of the [transcription factor] , nuclear factor kB ( NFkappaB ) , in the NHBE cells . Positive_regulation TCF12 CCND1 23135283 2707305 We find that knockdown of PAX2 inhibits the activity of AP-1 , a [transcription factor] that *induces* expression , implying that PAX2 induces cyclin D1 through AP-1 . Positive_regulation TCF12 CCND1 24979278 2947639 Thus , full activation of promoter activity *requires* ß-catenin activation of [TCF-lef] and stabilization of specific p120 catenin isoforms to relieve the repression of KAISO . Positive_regulation TCF12 CCND1 7970707 280059 *Activation* of the E2F [transcription factor] by is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation TCF12 CTGF 15601748 1361746 K252a , a known selective inhibitor of Trk , blocked this phosphorylation , induced *activation* of signaling proteins , and CTGF dependent induction of the [transcription factor] TGF-beta-inducible early gene in HMC . Positive_regulation TCF12 EPHB2 11784711 922008 Superoxide mediates shock wave induction of *dependent* osteogenic [transcription factor] ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors . Positive_regulation TCF12 EPHB2 11880483 919396 BDNF-LTP was further coupled to *dependent* phosphorylation of the [transcription factor] cAMP response element binding protein . Positive_regulation TCF12 EPHB2 15089040 1237815 Several reports indicate that the activation of extracellular signal regulated kinase ( ) *induces* microphthalmia associated [transcription factor] ( MITF ) degradation . Positive_regulation TCF12 EPHB2 15253728 1271680 *induces* increases in activator protein-1 (AP-1) [transcription factor] activity which may augment mesangial cell proliferation and ECM protein production . Positive_regulation TCF12 EPHB2 17117479 1677434 Finally , we show that activated *induced* increased expression of the Egr-1 [transcription factor] , which then bound to the promoter region of p35 . Positive_regulation TCF12 EPHB2 19910471 2189311 Active *increases* expression and activity of the c-Jun [transcription factor] , linking ERK and Jun N-terminal kinase (JNK) cascades . Positive_regulation TCF12 EPHB2 21144616 2419237 Receptors that belong to the family of death-receptors including TNF receptor-1 (TNF-R1) , CD95 ( Fas , APO-1 ) and TRAIL receptors ( TRAIL-R1 , TRAIL R2/DR4/DR5 ) transduce signals resulting in entirely different biological outcomes : They promote cell death via apoptosis but are also capable of inducing anti-apoptotic signals through the [transcription factor] nuclear factor NF-?B or *activation* of the proliferative protein kinase cascade resulting in cell protection and tissue regeneration . Positive_regulation TCF12 EPHB2 21890597 2506380 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and *dependent* activation of the CCAAT/enhancer binding protein beta [transcription factor] independent of p53 . Positive_regulation TCF12 EPHB2 24085800 2902609 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of and *activation* of Ets-1 [transcription factor] . Positive_regulation TCF12 EPHB2 8657129 364837 Analysis of the *stimulated* ETS [transcription factor] ER81 . Positive_regulation TCF12 FBXO32 18367868 1898769 FoxO3 [transcription factor] causes marked atrophy in adult skeletal muscle and *induces* the muscle-specific ubiquitin ligase ( 1 ) In addition , we recently reported that FoxO3 is necessary and sufficient for the induction of autophagy in skeletal muscle . Positive_regulation TCF12 HBEGF 23909989 2861556 Heparin-binding-epidermal growth factor ( ) down-regulates Claudin-3 expression , but *enhances* [transcription factor] Snail expression . Positive_regulation TCF12 IL1B 10816656 580251 Since the molecular basis of these antiinflammatory effects is not well known , the influence of alpha-MSH on *induced* chemokine production and [transcription factor] activation was investigated in human keratinocytes . Positive_regulation TCF12 IL1B 15217752 1263814 However , the contribution by p38 to the induction of inducible nitric oxide synthase (iNOS) and apoptosis is independent of NF-kappaB nuclear translocation since SB203580 does not prevent *induced* DNA binding of this [transcription factor] . Positive_regulation TCF12 IL1B 16326073 1553757 induced NF-kappaB activation in Caco-2 cells , *promoting* the binding of this [transcription factor] to DNA and increasing NF-kappaB dependent transcription . Positive_regulation TCF12 IL1B 16569740 1568481 OTR promoter contains putative [transcription factor] binding sites for activating protein-1 (AP-1) , CCAAT/enhancer binding protein (C/EBP) , and nuclear factor-kappaB (NF-kappaB) , which may be *activated* by , whose concentrations increase with labor . Positive_regulation TCF12 IL1B 16855208 1632214 The induced expression of human prostaglandin F2alpha receptor messenger RNA in human myometrial derived ULTR cells *requires* the [transcription factor] , NFkappaB . Positive_regulation TCF12 IL1B 18996492 2016027 Our results revealed that IL-1beta induced PBEF expression in pulmonary vascular endothelial cells at the transcriptional level and a -1535 T-variant in the human PBEF gene promoter significantly attenuated its binding to an *induced* unknown [transcription factor] . Positive_regulation TCF12 IL1B 8626526 360402 [Transcription factor] binding to the ATF/cAMP-responsive element consensus sequence was *increased* 4-5-fold by acetylsphingosine , PMA , or , whereas binding to the CCAAT/enhancer binding protein and AP-1 elements was found to be only slightly stimulated by these three agents . Positive_regulation TCF12 IL1B 8798568 381627 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by plus tumor necrosis factor-alpha , and its full induction *requires* the presence of the [transcription factor] , c-FOS . Positive_regulation TCF12 IL1B 9950608 589768 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to , tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Positive_regulation TCF12 ITGB2 15886116 1406815 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , *activation* of the NF-kappaB [transcription factor] , inside-out activation of the integrin , TCR clustering , and polarisation of the T cell . Positive_regulation TCF12 JAG1 16973960 1673620 and Delta-1 equally *activated* CBF-1/RBPJkappa [transcription factor] , which is a major Notch target . Positive_regulation TCF12 JAG1 17568183 1815664 [WNT-beta-catenin-TCF/LEF] signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , and DKK1 genes . Positive_regulation TCF12 NGFR 7536747 300268 In the case of purified Schwann cells , treatment with TGF-beta 1 increases their proliferation , and it promotes a pre- or nonmyelinating Schwann cell phenotype characterized by increased NCAM expression , decreased expression , inhibition of the forskolin mediated induction of the myelin protein P0 , and *induction* of the Schwann cell [transcription factor] suppressed cAMP-inducible POU protein . Positive_regulation TCF12 PTGER2 11706038 896739 We now report that the and EP(4) prostanoid receptors , which couple to Galpha ( s ) , also *activate* [Tcf/Lef] signaling . Positive_regulation TCF12 TCN1 18501609 1928126 Therefore , deficient may *lead* to abnormal expression of [TCF] . Positive_regulation TCF12 TLR7 19122179 2037109 signaling via p38 *led* to phosphorylation and activation of the transcription factor Microphthalmia [transcription factor] , acting at E-box elements in the Ctsk promoter . Positive_regulation TCF12 TNF 10075082 594839 Suppression of *activated* nuclear [transcription factor-kappaB] , activator protein-1 , c-Jun N-terminal kinase , and apoptosis by beta-lapachone . Positive_regulation TCF12 TNF 11093734 755011 Tumor necrosis factor alpha (TNF-alpha) binding to the initiates apoptosis and simultaneously *activates* the [transcription factor] , nuclear factor-kappaB (NF-kappaB) , which suppresses apoptosis by an unknown mechanism . Positive_regulation TCF12 TNF 11572998 864816 This study examines the effect of a triterpene mixture ( F094 ) and a single molecular species ( avicin G ) isolated from the mixture on induced *activation* of nuclear [transcription factor-kappaB] ( NF-kappaB ) in Jurkat cells ( human T cell leukemia ) . Positive_regulation TCF12 TNF 12091427 960124 Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB , whereas potently *induced* this [transcription factor] . Positive_regulation TCF12 TNF 12604246 1062593 Stimulation of the VECs with *led* to an increase in the DNA binding activity of the [transcription factor] , nuclear factor-kappa binding protein ( NF-kappaB ) and the induction of the adhesion molecule ( ICAM)-1 . Positive_regulation TCF12 TNF 12633744 1068268 Furthermore , treatment of HAEC with 0.5 mM DFO or NC completely inhibited *induced* activation of the [transcription factor] , specificity protein-1 (SP-1) , but only partially inhibited or did not affect activation of other transcription factors known to regulate adhesion molecule expression , i.e. , nuclear factor kappaB (NFkappaB) , activator protein-1 (AP-1) , and interferon regulatory factor-1 (IRF-1) . Positive_regulation TCF12 TNF 12810554 1102586 also *impairs* the ability of IGF-I to induce expression of a key myogenic [transcription factor] , myogenin . Positive_regulation TCF12 TNF 12890427 1117239 At the molecular level , EXPLY-37 did not inhibit the *activation* of the nuclear factor kappa B (NF-kappaB) [transcription factor] by . Positive_regulation TCF12 TNF 12893683 1135159 Ginkgo biloba extract inhibits *induced* reactive oxygen species generation , [transcription factor] activation , and cell adhesion molecule expression in human aortic endothelial cells . Positive_regulation TCF12 TNF 14646597 1173176 *induced* activation of both c-jun NH ( 2 ) -terminal kinase ( JNK ) and nuclear [transcription factor-kappaB] ( NF-kappaB ) in 3T3-L1 cells . Positive_regulation TCF12 TNF 15374848 1323846 Carvedilol inhibits *induced* endothelial [transcription factor] activation , adhesion molecule expression , and adhesiveness to human mononuclear cells . Positive_regulation TCF12 TNF 15593122 1361695 In the colons , a *inducing* [transcription factor] , LPS induced TNF-alpha factor (LITAF) , was inhibited by 1,25D3 , but not by calcium . Positive_regulation TCF12 TNF 15753227 1380075 and glucose *induced* a dose- and time dependent activation of the p38 MAP kinase , the downstream kinase mitogen- and stress activated kinase 1 , and the [transcription factor] cAMP-responsive element binding protein ( CREB ) , in EPCs . Positive_regulation TCF12 TNF 16006484 1459234 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the [transcription factor] ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TCF12 TNF 16046706 1438292 Palmitate activates the NF-kappaB [transcription factor] and *induces* IL-6 and expression in 3T3-L1 adipocytes . Positive_regulation TCF12 TNF 16338458 1503931 EMSA indicated *induced* binding of the inflammatory [transcription factor] to an NFkappaB consensus sequence and to the NFkappaB recognition site located in the PAI-1 promoter . Positive_regulation TCF12 TNF 16978650 1633536 Peptide YY reverses *induced* [transcription factor] binding of interferon regulatory factor-1 and p53 in pancreatic acinar cells . Positive_regulation TCF12 TNF 17035338 1674526 Taken together , our data suggest that the produced in response to IFN-gamma is *required* for iNOS induction by activating NF-kappaB [transcription factor] . Positive_regulation TCF12 TNF 17210691 1681507 The survival mechanism requires nuclear factor-kappaB (NF-kappaB) [transcription factor] activity , which is strongly *induced* by in these cells . Positive_regulation TCF12 TNF 17449583 1730000 Quercetin inhibits *induced* NF-kappaB [transcription factor] recruitment to proinflammatory gene promoters in murine intestinal epithelial cells . Positive_regulation TCF12 TNF 18094051 1868999 We find that NGF can *induce* synthesis through the nuclear factor-kappaB [transcription factor] . Positive_regulation TCF12 TNF 19138739 2037788 We examined whether or not 1alpha,25- ( OH ) ( 2 ) D ( 3 ) inhibits the *induced* activation of nuclear [transcription factor-kappaB] ( NF-kappaB ) , which is essential for the expression of proinflammatory cytokines in HCAEC , by ELISA . Positive_regulation TCF12 TNF 20133051 2242213 In the search of the molecular mechanisms responsible for the sensitization effect of chrysin , we discovered that such sensitization is closely associated with the inhibitory effect of chrysin on *mediated* nuclear [transcription factor-kappaB] ( NF-kappaB ) activation . Positive_regulation TCF12 TNF 20617556 2286543 Overexpression of the p65/RelA subunit of NF-kappaB , a *activated* inflammatory [transcription factor] , in A7r5 cells , upregulated SIRT1 mRNA and protein expression as well as SIRT1 promoter activity , while knockdown of endogenous p65/RelA expression by RNAi not only led to a decrease in SIRT1 's basal protein expression and promoter activity , but almost abolished the TNF-alpha induced elevation of SIRT1 protein expression and SIRT1 promoter activity . Positive_regulation TCF12 TNF 2104232 150535 *induces* binding of the NF-kappa B [transcription factor] to a high-affinity kappa B element in the TNF-beta promoter . Positive_regulation TCF12 TNF 21389273 2443500 Functionally , TNF-a stimulated H ( 2 ) O ( 2 ) production was also blocked by MCD and DES ( 194.6 ± 15.4 % vs. 90.6 ± 15.9 % and 148.8 ± 20.4 % ) , and the *activation* of the pivotal proinflammatory [transcription factor] , NF-?B , by was reversed by MCD and DES as well as by small interfering RNAs of Duox1 or ASMase . Positive_regulation TCF12 TNF 21541574 407724 These results are in contrast to those reported for the murine p53 gene , whose promoter is *induced* by through activation of the NF-kappa B [transcription factor] . Positive_regulation TCF12 TNF 8798568 381626 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by interleukin-1beta plus , and its full induction *requires* the presence of the [transcription factor] , c-FOS . Positive_regulation TCF12 TNF 9582369 504180 Overexpression of manganese superoxide dismutase suppresses *induced* apoptosis and activation of nuclear [transcription factor-kappaB] and activated protein-1 . Positive_regulation TCF12 TNF 9794740 543098 To determine whether the [transcription factor] nuclear factor-kappaB mediated expression of these genes involved in the inflammatory *response* of endothelial cells to , by using transcription factor decoy oligodeoxynucleotides . Positive_regulation TCF12 TNF 9950608 589766 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to interleukin-1beta (IL-1beta) , , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Positive_regulation TCF12 TP63 21741828 2599099 In this study we show that *induces* the expression of the basal epithelial [transcription factor] , Basonuclin 1 . Positive_regulation TCF12 WNT7A 11782388 900377 Coculture experiments demonstrated that Wnt-1 , but not Wnt-5A and , *activated* the [TCF] reporter gene . Positive_regulation TCF12 WNT7A 17431004 1748940 *stimulated* a [TCF/LEF-luciferase] reporter activity in ovine trophectoderm cells that was inhibited by dominant negative TCF and Sfrp2 ( secreted FZD related protein 2 ) . Positive_regulation TCF12 ZFP57 19234145 2072107 The other was the 5 ' noncoding region of a [transcription factor] , Zfp423 , which *induced* aberrant expression . Positive_regulation TCF15 ADRB2 15024018 1243838 To identify the mechanism responsible for this effect , we determined whether CD86 and/or stimulation *regulated* [transcription factor] expression and binding to the 3'-IgH enhancer in vitro and in vivo . Positive_regulation TCF15 AXIN2 11809808 906680 [Wnt/beta-catenin/Tcf] signaling *induces* the transcription of , a negative regulator of the signaling pathway . Positive_regulation TCF15 CCND1 14706452 1196349 The strong binding of E2F1 and NFkappaB is especially noteworthy , because the former [transcription factor] is *regulated* by , a downstream target of beta-catenin/TCF/LEF signaling , whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways . Positive_regulation TCF15 CCND1 15893541 1407588 The increased protein level was *induced* through activation of the [transcription factor] , nuclear factor kB ( NFkappaB ) , in the NHBE cells . Positive_regulation TCF15 CCND1 23135283 2707306 We find that knockdown of PAX2 inhibits the activity of AP-1 , a [transcription factor] that *induces* expression , implying that PAX2 induces cyclin D1 through AP-1 . Positive_regulation TCF15 CCND1 24979278 2947640 Thus , full activation of promoter activity *requires* ß-catenin activation of [TCF-lef] and stabilization of specific p120 catenin isoforms to relieve the repression of KAISO . Positive_regulation TCF15 CCND1 7970707 280061 *Activation* of the E2F [transcription factor] by is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation TCF15 CTGF 15601748 1361747 K252a , a known selective inhibitor of Trk , blocked this phosphorylation , induced *activation* of signaling proteins , and CTGF dependent induction of the [transcription factor] TGF-beta-inducible early gene in HMC . Positive_regulation TCF15 EPHB2 11784711 922009 Superoxide mediates shock wave induction of *dependent* osteogenic [transcription factor] ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors . Positive_regulation TCF15 EPHB2 11880483 919397 BDNF-LTP was further coupled to *dependent* phosphorylation of the [transcription factor] cAMP response element binding protein . Positive_regulation TCF15 EPHB2 15089040 1237816 Several reports indicate that the activation of extracellular signal regulated kinase ( ) *induces* microphthalmia associated [transcription factor] ( MITF ) degradation . Positive_regulation TCF15 EPHB2 15253728 1271681 *induces* increases in activator protein-1 (AP-1) [transcription factor] activity which may augment mesangial cell proliferation and ECM protein production . Positive_regulation TCF15 EPHB2 17117479 1677435 Finally , we show that activated *induced* increased expression of the Egr-1 [transcription factor] , which then bound to the promoter region of p35 . Positive_regulation TCF15 EPHB2 19910471 2189312 Active *increases* expression and activity of the c-Jun [transcription factor] , linking ERK and Jun N-terminal kinase (JNK) cascades . Positive_regulation TCF15 EPHB2 21144616 2419251 Receptors that belong to the family of death-receptors including TNF receptor-1 (TNF-R1) , CD95 ( Fas , APO-1 ) and TRAIL receptors ( TRAIL-R1 , TRAIL R2/DR4/DR5 ) transduce signals resulting in entirely different biological outcomes : They promote cell death via apoptosis but are also capable of inducing anti-apoptotic signals through the [transcription factor] nuclear factor NF-?B or *activation* of the proliferative protein kinase cascade resulting in cell protection and tissue regeneration . Positive_regulation TCF15 EPHB2 21890597 2506381 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and dependent *activation* of the CCAAT/enhancer binding protein beta [transcription factor] independent of p53 . Positive_regulation TCF15 EPHB2 24085800 2902610 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of and *activation* of Ets-1 [transcription factor] . Positive_regulation TCF15 EPHB2 8657129 364838 Analysis of the *stimulated* ETS [transcription factor] ER81 . Positive_regulation TCF15 FBXO32 18367868 1898770 FoxO3 [transcription factor] causes marked atrophy in adult skeletal muscle and *induces* the muscle-specific ubiquitin ligase ( 1 ) In addition , we recently reported that FoxO3 is necessary and sufficient for the induction of autophagy in skeletal muscle . Positive_regulation TCF15 HBEGF 23909989 2861558 Heparin-binding-epidermal growth factor ( ) down-regulates Claudin-3 expression , but *enhances* [transcription factor] Snail expression . Positive_regulation TCF15 IL1B 10816656 580252 Since the molecular basis of these antiinflammatory effects is not well known , the influence of alpha-MSH on induced chemokine production and [transcription factor] *activation* was investigated in human keratinocytes . Positive_regulation TCF15 IL1B 15217752 1263815 However , the contribution by p38 to the induction of inducible nitric oxide synthase (iNOS) and apoptosis is independent of NF-kappaB nuclear translocation since SB203580 does not prevent *induced* DNA binding of this [transcription factor] . Positive_regulation TCF15 IL1B 16326073 1553760 induced NF-kappaB activation in Caco-2 cells , *promoting* the binding of this [transcription factor] to DNA and increasing NF-kappaB dependent transcription . Positive_regulation TCF15 IL1B 16569740 1568482 OTR promoter contains putative [transcription factor] binding sites for activating protein-1 (AP-1) , CCAAT/enhancer binding protein (C/EBP) , and nuclear factor-kappaB (NF-kappaB) , which may be *activated* by , whose concentrations increase with labor . Positive_regulation TCF15 IL1B 16855208 1632215 The induced expression of human prostaglandin F2alpha receptor messenger RNA in human myometrial derived ULTR cells *requires* the [transcription factor] , NFkappaB . Positive_regulation TCF15 IL1B 18996492 2016028 Our results revealed that IL-1beta induced PBEF expression in pulmonary vascular endothelial cells at the transcriptional level and a -1535 T-variant in the human PBEF gene promoter significantly attenuated its binding to an *induced* unknown [transcription factor] . Positive_regulation TCF15 IL1B 8626526 360403 [Transcription factor] binding to the ATF/cAMP-responsive element consensus sequence was *increased* 4-5-fold by acetylsphingosine , PMA , or , whereas binding to the CCAAT/enhancer binding protein and AP-1 elements was found to be only slightly stimulated by these three agents . Positive_regulation TCF15 IL1B 8798568 381629 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by plus tumor necrosis factor-alpha , and its full induction *requires* the presence of the [transcription factor] , c-FOS . Positive_regulation TCF15 IL1B 9950608 589771 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to , tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Positive_regulation TCF15 ITGB2 15886116 1406817 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , *activation* of the NF-kappaB [transcription factor] , inside-out activation of the integrin , TCR clustering , and polarisation of the T cell . Positive_regulation TCF15 JAG1 16973960 1673622 and Delta-1 equally *activated* CBF-1/RBPJkappa [transcription factor] , which is a major Notch target . Positive_regulation TCF15 JAG1 17568183 1815667 [WNT-beta-catenin-TCF/LEF] signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , and DKK1 genes . Positive_regulation TCF15 NGFR 7536747 300270 In the case of purified Schwann cells , treatment with TGF-beta 1 increases their proliferation , and it promotes a pre- or nonmyelinating Schwann cell phenotype characterized by increased NCAM expression , decreased expression , inhibition of the forskolin mediated induction of the myelin protein P0 , and *induction* of the Schwann cell [transcription factor] suppressed cAMP-inducible POU protein . Positive_regulation TCF15 PTGER2 11706038 896741 We now report that the and EP(4) prostanoid receptors , which couple to Galpha ( s ) , also *activate* [Tcf/Lef] signaling . Positive_regulation TCF15 TCN1 18501609 1928127 Therefore , deficient may *lead* to abnormal expression of [TCF] . Positive_regulation TCF15 TLR7 19122179 2037119 signaling via p38 *led* to phosphorylation and activation of the transcription factor Microphthalmia [transcription factor] , acting at E-box elements in the Ctsk promoter . Positive_regulation TCF15 TNF 10075082 594840 Suppression of *activated* nuclear [transcription factor-kappaB] , activator protein-1 , c-Jun N-terminal kinase , and apoptosis by beta-lapachone . Positive_regulation TCF15 TNF 11093734 755012 binding to the TNF receptor (TNFR) initiates apoptosis and simultaneously *activates* the [transcription factor] , nuclear factor-kappaB (NF-kappaB) , which suppresses apoptosis by an unknown mechanism . Positive_regulation TCF15 TNF 11572998 864817 This study examines the effect of a triterpene mixture ( F094 ) and a single molecular species ( avicin G ) isolated from the mixture on *induced* activation of nuclear [transcription factor-kappaB] ( NF-kappaB ) in Jurkat cells ( human T cell leukemia ) . Positive_regulation TCF15 TNF 12091427 960125 Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB , whereas potently *induced* this [transcription factor] . Positive_regulation TCF15 TNF 12604246 1062594 Stimulation of the VECs with *led* to an increase in the DNA binding activity of the [transcription factor] , nuclear factor-kappa binding protein ( NF-kappaB ) and the induction of the adhesion molecule ( ICAM)-1 . Positive_regulation TCF15 TNF 12633744 1068269 Furthermore , treatment of HAEC with 0.5 mM DFO or NC completely inhibited induced *activation* of the [transcription factor] , specificity protein-1 (SP-1) , but only partially inhibited or did not affect activation of other transcription factors known to regulate adhesion molecule expression , i.e. , nuclear factor kappaB (NFkappaB) , activator protein-1 (AP-1) , and interferon regulatory factor-1 (IRF-1) . Positive_regulation TCF15 TNF 12810554 1102588 also *impairs* the ability of IGF-I to induce expression of a key myogenic [transcription factor] , myogenin . Positive_regulation TCF15 TNF 12890427 1117240 At the molecular level , EXPLY-37 did not inhibit the *activation* of the nuclear factor kappa B (NF-kappaB) [transcription factor] by . Positive_regulation TCF15 TNF 12893683 1135160 Ginkgo biloba extract inhibits induced reactive oxygen species generation , [transcription factor] *activation* , and cell adhesion molecule expression in human aortic endothelial cells . Positive_regulation TCF15 TNF 14646597 1173177 *induced* activation of both c-jun NH ( 2 ) -terminal kinase ( JNK ) and nuclear [transcription factor-kappaB] ( NF-kappaB ) in 3T3-L1 cells . Positive_regulation TCF15 TNF 15374848 1323847 Carvedilol inhibits induced endothelial [transcription factor] *activation* , adhesion molecule expression , and adhesiveness to human mononuclear cells . Positive_regulation TCF15 TNF 15593122 1361696 In the colons , a *inducing* [transcription factor] , LPS induced TNF-alpha factor (LITAF) , was inhibited by 1,25D3 , but not by calcium . Positive_regulation TCF15 TNF 15753227 1380076 and glucose *induced* a dose- and time dependent activation of the p38 MAP kinase , the downstream kinase mitogen- and stress activated kinase 1 , and the [transcription factor] cAMP-responsive element binding protein ( CREB ) , in EPCs . Positive_regulation TCF15 TNF 16006484 1459236 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the [transcription factor] ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TCF15 TNF 16046706 1438294 Palmitate activates the NF-kappaB [transcription factor] and *induces* IL-6 and expression in 3T3-L1 adipocytes . Positive_regulation TCF15 TNF 16338458 1503932 EMSA indicated *induced* binding of the inflammatory [transcription factor] to an NFkappaB consensus sequence and to the NFkappaB recognition site located in the PAI-1 promoter . Positive_regulation TCF15 TNF 16978650 1633537 Peptide YY reverses *induced* [transcription factor] binding of interferon regulatory factor-1 and p53 in pancreatic acinar cells . Positive_regulation TCF15 TNF 17035338 1674527 Taken together , our data suggest that the produced in response to IFN-gamma is *required* for iNOS induction by activating NF-kappaB [transcription factor] . Positive_regulation TCF15 TNF 17210691 1681508 The survival mechanism requires nuclear factor-kappaB (NF-kappaB) [transcription factor] activity , which is strongly *induced* by in these cells . Positive_regulation TCF15 TNF 17449583 1730001 Quercetin inhibits *induced* NF-kappaB [transcription factor] recruitment to proinflammatory gene promoters in murine intestinal epithelial cells . Positive_regulation TCF15 TNF 18094051 1869001 We find that NGF can *induce* synthesis through the nuclear factor-kappaB [transcription factor] . Positive_regulation TCF15 TNF 19138739 2037789 We examined whether or not 1alpha,25- ( OH ) ( 2 ) D ( 3 ) inhibits the induced *activation* of nuclear [transcription factor-kappaB] ( NF-kappaB ) , which is essential for the expression of proinflammatory cytokines in HCAEC , by ELISA . Positive_regulation TCF15 TNF 20133051 2242214 In the search of the molecular mechanisms responsible for the sensitization effect of chrysin , we discovered that such sensitization is closely associated with the inhibitory effect of chrysin on *mediated* nuclear [transcription factor-kappaB] ( NF-kappaB ) activation . Positive_regulation TCF15 TNF 20617556 2286544 Overexpression of the p65/RelA subunit of NF-kappaB , a *activated* inflammatory [transcription factor] , in A7r5 cells , upregulated SIRT1 mRNA and protein expression as well as SIRT1 promoter activity , while knockdown of endogenous p65/RelA expression by RNAi not only led to a decrease in SIRT1 's basal protein expression and promoter activity , but almost abolished the TNF-alpha induced elevation of SIRT1 protein expression and SIRT1 promoter activity . Positive_regulation TCF15 TNF 2104232 150536 *induces* binding of the NF-kappa B [transcription factor] to a high-affinity kappa B element in the TNF-beta promoter . Positive_regulation TCF15 TNF 21389273 2443501 Functionally , TNF-a stimulated H ( 2 ) O ( 2 ) production was also blocked by MCD and DES ( 194.6 ± 15.4 % vs. 90.6 ± 15.9 % and 148.8 ± 20.4 % ) , and the *activation* of the pivotal proinflammatory [transcription factor] , NF-?B , by was reversed by MCD and DES as well as by small interfering RNAs of Duox1 or ASMase . Positive_regulation TCF15 TNF 21541574 407725 These results are in contrast to those reported for the murine p53 gene , whose promoter is *induced* by through activation of the NF-kappa B [transcription factor] . Positive_regulation TCF15 TNF 8798568 381628 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by interleukin-1beta plus , and its full induction *requires* the presence of the [transcription factor] , c-FOS . Positive_regulation TCF15 TNF 9582369 504181 Overexpression of manganese superoxide dismutase suppresses *induced* apoptosis and activation of nuclear [transcription factor-kappaB] and activated protein-1 . Positive_regulation TCF15 TNF 9794740 543099 To determine whether the [transcription factor] nuclear factor-kappaB mediated expression of these genes involved in the inflammatory *response* of endothelial cells to , by using transcription factor decoy oligodeoxynucleotides . Positive_regulation TCF15 TNF 9950608 589769 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to interleukin-1beta (IL-1beta) , , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Positive_regulation TCF15 TP63 21741828 2599100 In this study we show that *induces* the expression of the basal epithelial [transcription factor] , Basonuclin 1 . Positive_regulation TCF15 WNT7A 11782388 900380 Coculture experiments demonstrated that Wnt-1 , but not Wnt-5A and , *activated* the [TCF] reporter gene . Positive_regulation TCF15 WNT7A 17431004 1748941 *stimulated* a [TCF/LEF-luciferase] reporter activity in ovine trophectoderm cells that was inhibited by dominant negative TCF and Sfrp2 ( secreted FZD related protein 2 ) . Positive_regulation TCF15 ZFP57 19234145 2072125 The other was the 5 ' noncoding region of a [transcription factor] , Zfp423 , which *induced* aberrant expression . Positive_regulation TCF19 ADRB2 15024018 1243840 To identify the mechanism responsible for this effect , we determined whether CD86 and/or stimulation *regulated* [transcription factor] expression and binding to the 3'-IgH enhancer in vitro and in vivo . Positive_regulation TCF19 AXIN2 11809808 906681 [Wnt/beta-catenin/Tcf] signaling *induces* the transcription of , a negative regulator of the signaling pathway . Positive_regulation TCF19 CCND1 14706452 1196350 The strong binding of E2F1 and NFkappaB is especially noteworthy , because the former [transcription factor] is *regulated* by , a downstream target of beta-catenin/TCF/LEF signaling , whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways . Positive_regulation TCF19 CCND1 15893541 1407589 The increased protein level was *induced* through activation of the [transcription factor] , nuclear factor kB ( NFkappaB ) , in the NHBE cells . Positive_regulation TCF19 CCND1 23135283 2707307 We find that knockdown of PAX2 inhibits the activity of AP-1 , a [transcription factor] that *induces* expression , implying that PAX2 induces cyclin D1 through AP-1 . Positive_regulation TCF19 CCND1 24979278 2947641 Thus , full activation of promoter activity *requires* ß-catenin activation of [TCF-lef] and stabilization of specific p120 catenin isoforms to relieve the repression of KAISO . Positive_regulation TCF19 CCND1 7970707 280063 *Activation* of the E2F [transcription factor] by is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation TCF19 CTGF 15601748 1361748 K252a , a known selective inhibitor of Trk , blocked this phosphorylation , CTGF induced activation of signaling proteins , and dependent *induction* of the [transcription factor] TGF-beta-inducible early gene in HMC . Positive_regulation TCF19 EPHB2 11784711 922010 Superoxide mediates shock wave induction of *dependent* osteogenic [transcription factor] ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors . Positive_regulation TCF19 EPHB2 11880483 919398 BDNF-LTP was further coupled to *dependent* phosphorylation of the [transcription factor] cAMP response element binding protein . Positive_regulation TCF19 EPHB2 15089040 1237817 Several reports indicate that the activation of extracellular signal regulated kinase ( ) *induces* microphthalmia associated [transcription factor] ( MITF ) degradation . Positive_regulation TCF19 EPHB2 15253728 1271682 *induces* increases in activator protein-1 (AP-1) [transcription factor] activity which may augment mesangial cell proliferation and ECM protein production . Positive_regulation TCF19 EPHB2 17117479 1677436 Finally , we show that activated *induced* increased expression of the Egr-1 [transcription factor] , which then bound to the promoter region of p35 . Positive_regulation TCF19 EPHB2 19910471 2189313 Active *increases* expression and activity of the c-Jun [transcription factor] , linking ERK and Jun N-terminal kinase (JNK) cascades . Positive_regulation TCF19 EPHB2 21144616 2419265 Receptors that belong to the family of death-receptors including TNF receptor-1 (TNF-R1) , CD95 ( Fas , APO-1 ) and TRAIL receptors ( TRAIL-R1 , TRAIL R2/DR4/DR5 ) transduce signals resulting in entirely different biological outcomes : They promote cell death via apoptosis but are also capable of inducing anti-apoptotic signals through the [transcription factor] nuclear factor NF-?B or *activation* of the proliferative protein kinase cascade resulting in cell protection and tissue regeneration . Positive_regulation TCF19 EPHB2 21890597 2506382 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and *dependent* activation of the CCAAT/enhancer binding protein beta [transcription factor] independent of p53 . Positive_regulation TCF19 EPHB2 24085800 2902611 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of and *activation* of Ets-1 [transcription factor] . Positive_regulation TCF19 EPHB2 8657129 364839 Analysis of the *stimulated* ETS [transcription factor] ER81 . Positive_regulation TCF19 FBXO32 18367868 1898771 FoxO3 [transcription factor] causes marked atrophy in adult skeletal muscle and *induces* the muscle-specific ubiquitin ligase ( 1 ) In addition , we recently reported that FoxO3 is necessary and sufficient for the induction of autophagy in skeletal muscle . Positive_regulation TCF19 HBEGF 23909989 2861560 Heparin-binding-epidermal growth factor ( ) down-regulates Claudin-3 expression , but *enhances* [transcription factor] Snail expression . Positive_regulation TCF19 IL1B 10816656 580253 Since the molecular basis of these antiinflammatory effects is not well known , the influence of alpha-MSH on *induced* chemokine production and [transcription factor] activation was investigated in human keratinocytes . Positive_regulation TCF19 IL1B 15217752 1263816 However , the contribution by p38 to the induction of inducible nitric oxide synthase (iNOS) and apoptosis is independent of NF-kappaB nuclear translocation since SB203580 does not prevent *induced* DNA binding of this [transcription factor] . Positive_regulation TCF19 IL1B 16326073 1553763 induced NF-kappaB activation in Caco-2 cells , *promoting* the binding of this [transcription factor] to DNA and increasing NF-kappaB dependent transcription . Positive_regulation TCF19 IL1B 16569740 1568483 OTR promoter contains putative [transcription factor] binding sites for activating protein-1 (AP-1) , CCAAT/enhancer binding protein (C/EBP) , and nuclear factor-kappaB (NF-kappaB) , which may be *activated* by , whose concentrations increase with labor . Positive_regulation TCF19 IL1B 16855208 1632216 The induced expression of human prostaglandin F2alpha receptor messenger RNA in human myometrial derived ULTR cells *requires* the [transcription factor] , NFkappaB . Positive_regulation TCF19 IL1B 18996492 2016029 Our results revealed that IL-1beta induced PBEF expression in pulmonary vascular endothelial cells at the transcriptional level and a -1535 T-variant in the human PBEF gene promoter significantly attenuated its binding to an *induced* unknown [transcription factor] . Positive_regulation TCF19 IL1B 8626526 360404 [Transcription factor] binding to the ATF/cAMP-responsive element consensus sequence was *increased* 4-5-fold by acetylsphingosine , PMA , or , whereas binding to the CCAAT/enhancer binding protein and AP-1 elements was found to be only slightly stimulated by these three agents . Positive_regulation TCF19 IL1B 8798568 381631 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by plus tumor necrosis factor-alpha , and its full induction *requires* the presence of the [transcription factor] , c-FOS . Positive_regulation TCF19 IL1B 9950608 589774 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to , tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Positive_regulation TCF19 ITGB2 15886116 1406819 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , *activation* of the NF-kappaB [transcription factor] , inside-out activation of the integrin , TCR clustering , and polarisation of the T cell . Positive_regulation TCF19 JAG1 16973960 1673624 and Delta-1 equally *activated* CBF-1/RBPJkappa [transcription factor] , which is a major Notch target . Positive_regulation TCF19 JAG1 17568183 1815670 [WNT-beta-catenin-TCF/LEF] signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , and DKK1 genes . Positive_regulation TCF19 NGFR 7536747 300272 In the case of purified Schwann cells , treatment with TGF-beta 1 increases their proliferation , and it promotes a pre- or nonmyelinating Schwann cell phenotype characterized by increased NCAM expression , decreased expression , inhibition of the forskolin mediated induction of the myelin protein P0 , and *induction* of the Schwann cell [transcription factor] suppressed cAMP-inducible POU protein . Positive_regulation TCF19 PTGER2 11706038 896743 We now report that the and EP(4) prostanoid receptors , which couple to Galpha ( s ) , also *activate* [Tcf/Lef] signaling . Positive_regulation TCF19 TCN1 18501609 1928128 Therefore , deficient may *lead* to abnormal expression of [TCF] . Positive_regulation TCF19 TLR7 19122179 2037129 signaling via p38 *led* to phosphorylation and activation of the transcription factor Microphthalmia [transcription factor] , acting at E-box elements in the Ctsk promoter . Positive_regulation TCF19 TNF 10075082 594841 Suppression of *activated* nuclear [transcription factor-kappaB] , activator protein-1 , c-Jun N-terminal kinase , and apoptosis by beta-lapachone . Positive_regulation TCF19 TNF 11093734 755013 binding to the TNF receptor (TNFR) initiates apoptosis and simultaneously *activates* the [transcription factor] , nuclear factor-kappaB (NF-kappaB) , which suppresses apoptosis by an unknown mechanism . Positive_regulation TCF19 TNF 11572998 864818 This study examines the effect of a triterpene mixture ( F094 ) and a single molecular species ( avicin G ) isolated from the mixture on induced *activation* of nuclear [transcription factor-kappaB] ( NF-kappaB ) in Jurkat cells ( human T cell leukemia ) . Positive_regulation TCF19 TNF 12091427 960126 Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB , whereas potently *induced* this [transcription factor] . Positive_regulation TCF19 TNF 12604246 1062595 Stimulation of the VECs with *led* to an increase in the DNA binding activity of the [transcription factor] , nuclear factor-kappa binding protein ( NF-kappaB ) and the induction of the adhesion molecule ( ICAM)-1 . Positive_regulation TCF19 TNF 12633744 1068270 Furthermore , treatment of HAEC with 0.5 mM DFO or NC completely inhibited *induced* activation of the [transcription factor] , specificity protein-1 (SP-1) , but only partially inhibited or did not affect activation of other transcription factors known to regulate adhesion molecule expression , i.e. , nuclear factor kappaB (NFkappaB) , activator protein-1 (AP-1) , and interferon regulatory factor-1 (IRF-1) . Positive_regulation TCF19 TNF 12810554 1102590 also *impairs* the ability of IGF-I to induce expression of a key myogenic [transcription factor] , myogenin . Positive_regulation TCF19 TNF 12890427 1117241 At the molecular level , EXPLY-37 did not inhibit the *activation* of the nuclear factor kappa B (NF-kappaB) [transcription factor] by . Positive_regulation TCF19 TNF 12893683 1135161 Ginkgo biloba extract inhibits *induced* reactive oxygen species generation , [transcription factor] activation , and cell adhesion molecule expression in human aortic endothelial cells . Positive_regulation TCF19 TNF 14646597 1173178 *induced* activation of both c-jun NH ( 2 ) -terminal kinase ( JNK ) and nuclear [transcription factor-kappaB] ( NF-kappaB ) in 3T3-L1 cells . Positive_regulation TCF19 TNF 15374848 1323848 Carvedilol inhibits *induced* endothelial [transcription factor] activation , adhesion molecule expression , and adhesiveness to human mononuclear cells . Positive_regulation TCF19 TNF 15593122 1361697 In the colons , a *inducing* [transcription factor] , LPS induced TNF-alpha factor (LITAF) , was inhibited by 1,25D3 , but not by calcium . Positive_regulation TCF19 TNF 15753227 1380077 and glucose *induced* a dose- and time dependent activation of the p38 MAP kinase , the downstream kinase mitogen- and stress activated kinase 1 , and the [transcription factor] cAMP-responsive element binding protein ( CREB ) , in EPCs . Positive_regulation TCF19 TNF 16006484 1459238 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the [transcription factor] ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TCF19 TNF 16046706 1438296 Palmitate activates the NF-kappaB [transcription factor] and *induces* IL-6 and expression in 3T3-L1 adipocytes . Positive_regulation TCF19 TNF 16338458 1503933 EMSA indicated *induced* binding of the inflammatory [transcription factor] to an NFkappaB consensus sequence and to the NFkappaB recognition site located in the PAI-1 promoter . Positive_regulation TCF19 TNF 16978650 1633538 Peptide YY reverses *induced* [transcription factor] binding of interferon regulatory factor-1 and p53 in pancreatic acinar cells . Positive_regulation TCF19 TNF 17035338 1674528 Taken together , our data suggest that the produced in response to IFN-gamma is *required* for iNOS induction by activating NF-kappaB [transcription factor] . Positive_regulation TCF19 TNF 17210691 1681509 The survival mechanism requires nuclear factor-kappaB (NF-kappaB) [transcription factor] activity , which is strongly *induced* by in these cells . Positive_regulation TCF19 TNF 17449583 1730002 Quercetin inhibits *induced* NF-kappaB [transcription factor] recruitment to proinflammatory gene promoters in murine intestinal epithelial cells . Positive_regulation TCF19 TNF 18094051 1869003 We find that NGF can *induce* synthesis through the nuclear factor-kappaB [transcription factor] . Positive_regulation TCF19 TNF 19138739 2037790 We examined whether or not 1alpha,25- ( OH ) ( 2 ) D ( 3 ) inhibits the *induced* activation of nuclear [transcription factor-kappaB] ( NF-kappaB ) , which is essential for the expression of proinflammatory cytokines in HCAEC , by ELISA . Positive_regulation TCF19 TNF 20133051 2242215 In the search of the molecular mechanisms responsible for the sensitization effect of chrysin , we discovered that such sensitization is closely associated with the inhibitory effect of chrysin on *mediated* nuclear [transcription factor-kappaB] ( NF-kappaB ) activation . Positive_regulation TCF19 TNF 20617556 2286545 Overexpression of the p65/RelA subunit of NF-kappaB , a *activated* inflammatory [transcription factor] , in A7r5 cells , upregulated SIRT1 mRNA and protein expression as well as SIRT1 promoter activity , while knockdown of endogenous p65/RelA expression by RNAi not only led to a decrease in SIRT1 's basal protein expression and promoter activity , but almost abolished the TNF-alpha induced elevation of SIRT1 protein expression and SIRT1 promoter activity . Positive_regulation TCF19 TNF 2104232 150537 *induces* binding of the NF-kappa B [transcription factor] to a high-affinity kappa B element in the TNF-beta promoter . Positive_regulation TCF19 TNF 21389273 2443502 Functionally , TNF-a stimulated H ( 2 ) O ( 2 ) production was also blocked by MCD and DES ( 194.6 ± 15.4 % vs. 90.6 ± 15.9 % and 148.8 ± 20.4 % ) , and the *activation* of the pivotal proinflammatory [transcription factor] , NF-?B , by was reversed by MCD and DES as well as by small interfering RNAs of Duox1 or ASMase . Positive_regulation TCF19 TNF 21541574 407726 These results are in contrast to those reported for the murine p53 gene , whose promoter is *induced* by through activation of the NF-kappa B [transcription factor] . Positive_regulation TCF19 TNF 8798568 381630 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by interleukin-1beta plus , and its full induction *requires* the presence of the [transcription factor] , c-FOS . Positive_regulation TCF19 TNF 9582369 504182 Overexpression of manganese superoxide dismutase suppresses *induced* apoptosis and activation of nuclear [transcription factor-kappaB] and activated protein-1 . Positive_regulation TCF19 TNF 9794740 543100 To determine whether the [transcription factor] nuclear factor-kappaB mediated expression of these genes involved in the inflammatory *response* of endothelial cells to , by using transcription factor decoy oligodeoxynucleotides . Positive_regulation TCF19 TNF 9950608 589772 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to interleukin-1beta (IL-1beta) , , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Positive_regulation TCF19 TP63 21741828 2599101 In this study we show that *induces* the expression of the basal epithelial [transcription factor] , Basonuclin 1 . Positive_regulation TCF19 WNT7A 11782388 900383 Coculture experiments demonstrated that Wnt-1 , but not Wnt-5A and , *activated* the [TCF] reporter gene . Positive_regulation TCF19 WNT7A 17431004 1748942 *stimulated* a [TCF/LEF-luciferase] reporter activity in ovine trophectoderm cells that was inhibited by dominant negative TCF and Sfrp2 ( secreted FZD related protein 2 ) . Positive_regulation TCF19 ZFP57 19234145 2072143 The other was the 5 ' noncoding region of a [transcription factor] , Zfp423 , which *induced* aberrant expression . Positive_regulation TCF20 ADRB2 15024018 1243842 To identify the mechanism responsible for this effect , we determined whether CD86 and/or stimulation *regulated* [transcription factor] expression and binding to the 3'-IgH enhancer in vitro and in vivo . Positive_regulation TCF20 AXIN2 11809808 906682 [Wnt/beta-catenin/Tcf] signaling *induces* the transcription of , a negative regulator of the signaling pathway . Positive_regulation TCF20 CCND1 14706452 1196351 The strong binding of E2F1 and NFkappaB is especially noteworthy , because the former [transcription factor] is *regulated* by , a downstream target of beta-catenin/TCF/LEF signaling , whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways . Positive_regulation TCF20 CCND1 15893541 1407590 The increased protein level was *induced* through activation of the [transcription factor] , nuclear factor kB ( NFkappaB ) , in the NHBE cells . Positive_regulation TCF20 CCND1 23135283 2707308 We find that knockdown of PAX2 inhibits the activity of AP-1 , a [transcription factor] that *induces* expression , implying that PAX2 induces cyclin D1 through AP-1 . Positive_regulation TCF20 CCND1 24979278 2947642 Thus , full activation of promoter activity *requires* ß-catenin activation of [TCF-lef] and stabilization of specific p120 catenin isoforms to relieve the repression of KAISO . Positive_regulation TCF20 CCND1 7970707 280065 *Activation* of the E2F [transcription factor] by is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation TCF20 CTGF 15601748 1361749 K252a , a known selective inhibitor of Trk , blocked this phosphorylation , induced *activation* of signaling proteins , and CTGF dependent induction of the [transcription factor] TGF-beta-inducible early gene in HMC . Positive_regulation TCF20 EPHB2 11784711 922011 Superoxide mediates shock wave induction of *dependent* osteogenic [transcription factor] ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors . Positive_regulation TCF20 EPHB2 11880483 919399 BDNF-LTP was further coupled to *dependent* phosphorylation of the [transcription factor] cAMP response element binding protein . Positive_regulation TCF20 EPHB2 15089040 1237818 Several reports indicate that the activation of extracellular signal regulated kinase ( ) *induces* microphthalmia associated [transcription factor] ( MITF ) degradation . Positive_regulation TCF20 EPHB2 15253728 1271683 *induces* increases in activator protein-1 (AP-1) [transcription factor] activity which may augment mesangial cell proliferation and ECM protein production . Positive_regulation TCF20 EPHB2 17117479 1677437 Finally , we show that activated *induced* increased expression of the Egr-1 [transcription factor] , which then bound to the promoter region of p35 . Positive_regulation TCF20 EPHB2 19910471 2189314 Active *increases* expression and activity of the c-Jun [transcription factor] , linking ERK and Jun N-terminal kinase (JNK) cascades . Positive_regulation TCF20 EPHB2 21144616 2419279 Receptors that belong to the family of death-receptors including TNF receptor-1 (TNF-R1) , CD95 ( Fas , APO-1 ) and TRAIL receptors ( TRAIL-R1 , TRAIL R2/DR4/DR5 ) transduce signals resulting in entirely different biological outcomes : They promote cell death via apoptosis but are also capable of inducing anti-apoptotic signals through the [transcription factor] nuclear factor NF-?B or *activation* of the proliferative protein kinase cascade resulting in cell protection and tissue regeneration . Positive_regulation TCF20 EPHB2 21890597 2506383 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and dependent *activation* of the CCAAT/enhancer binding protein beta [transcription factor] independent of p53 . Positive_regulation TCF20 EPHB2 24085800 2902612 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of and *activation* of Ets-1 [transcription factor] . Positive_regulation TCF20 EPHB2 8657129 364840 Analysis of the *stimulated* ETS [transcription factor] ER81 . Positive_regulation TCF20 FBXO32 18367868 1898772 FoxO3 [transcription factor] causes marked atrophy in adult skeletal muscle and *induces* the muscle-specific ubiquitin ligase ( 1 ) In addition , we recently reported that FoxO3 is necessary and sufficient for the induction of autophagy in skeletal muscle . Positive_regulation TCF20 HBEGF 23909989 2861562 Heparin-binding-epidermal growth factor ( ) down-regulates Claudin-3 expression , but *enhances* [transcription factor] Snail expression . Positive_regulation TCF20 IL1B 10816656 580254 Since the molecular basis of these antiinflammatory effects is not well known , the influence of alpha-MSH on induced chemokine production and [transcription factor] *activation* was investigated in human keratinocytes . Positive_regulation TCF20 IL1B 15217752 1263817 However , the contribution by p38 to the induction of inducible nitric oxide synthase (iNOS) and apoptosis is independent of NF-kappaB nuclear translocation since SB203580 does not prevent *induced* DNA binding of this [transcription factor] . Positive_regulation TCF20 IL1B 16326073 1553766 induced NF-kappaB activation in Caco-2 cells , *promoting* the binding of this [transcription factor] to DNA and increasing NF-kappaB dependent transcription . Positive_regulation TCF20 IL1B 16569740 1568484 OTR promoter contains putative [transcription factor] binding sites for activating protein-1 (AP-1) , CCAAT/enhancer binding protein (C/EBP) , and nuclear factor-kappaB (NF-kappaB) , which may be *activated* by , whose concentrations increase with labor . Positive_regulation TCF20 IL1B 16855208 1632217 The induced expression of human prostaglandin F2alpha receptor messenger RNA in human myometrial derived ULTR cells *requires* the [transcription factor] , NFkappaB . Positive_regulation TCF20 IL1B 18996492 2016030 Our results revealed that IL-1beta induced PBEF expression in pulmonary vascular endothelial cells at the transcriptional level and a -1535 T-variant in the human PBEF gene promoter significantly attenuated its binding to an *induced* unknown [transcription factor] . Positive_regulation TCF20 IL1B 8626526 360405 [Transcription factor] binding to the ATF/cAMP-responsive element consensus sequence was *increased* 4-5-fold by acetylsphingosine , PMA , or , whereas binding to the CCAAT/enhancer binding protein and AP-1 elements was found to be only slightly stimulated by these three agents . Positive_regulation TCF20 IL1B 8798568 381633 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by plus tumor necrosis factor-alpha , and its full induction *requires* the presence of the [transcription factor] , c-FOS . Positive_regulation TCF20 IL1B 9950608 589777 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to , tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Positive_regulation TCF20 ITGB2 15886116 1406821 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , *activation* of the NF-kappaB [transcription factor] , inside-out activation of the integrin , TCR clustering , and polarisation of the T cell . Positive_regulation TCF20 JAG1 16973960 1673626 and Delta-1 equally *activated* CBF-1/RBPJkappa [transcription factor] , which is a major Notch target . Positive_regulation TCF20 JAG1 17568183 1815673 [WNT-beta-catenin-TCF/LEF] signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , and DKK1 genes . Positive_regulation TCF20 NGFR 7536747 300274 In the case of purified Schwann cells , treatment with TGF-beta 1 increases their proliferation , and it promotes a pre- or nonmyelinating Schwann cell phenotype characterized by increased NCAM expression , decreased expression , inhibition of the forskolin mediated induction of the myelin protein P0 , and *induction* of the Schwann cell [transcription factor] suppressed cAMP-inducible POU protein . Positive_regulation TCF20 PTGER2 11706038 896745 We now report that the and EP(4) prostanoid receptors , which couple to Galpha ( s ) , also *activate* [Tcf/Lef] signaling . Positive_regulation TCF20 TCN1 18501609 1928129 Therefore , deficient may *lead* to abnormal expression of [TCF] . Positive_regulation TCF20 TLR7 19122179 2037139 signaling via p38 *led* to phosphorylation and activation of the transcription factor Microphthalmia [transcription factor] , acting at E-box elements in the Ctsk promoter . Positive_regulation TCF20 TNF 10075082 594842 Suppression of *activated* nuclear [transcription factor-kappaB] , activator protein-1 , c-Jun N-terminal kinase , and apoptosis by beta-lapachone . Positive_regulation TCF20 TNF 11093734 755014 Tumor necrosis factor alpha (TNF-alpha) binding to the initiates apoptosis and simultaneously *activates* the [transcription factor] , nuclear factor-kappaB (NF-kappaB) , which suppresses apoptosis by an unknown mechanism . Positive_regulation TCF20 TNF 11572998 864819 This study examines the effect of a triterpene mixture ( F094 ) and a single molecular species ( avicin G ) isolated from the mixture on *induced* activation of nuclear [transcription factor-kappaB] ( NF-kappaB ) in Jurkat cells ( human T cell leukemia ) . Positive_regulation TCF20 TNF 12091427 960127 Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB , whereas potently *induced* this [transcription factor] . Positive_regulation TCF20 TNF 12604246 1062596 Stimulation of the VECs with *led* to an increase in the DNA binding activity of the [transcription factor] , nuclear factor-kappa binding protein ( NF-kappaB ) and the induction of the adhesion molecule ( ICAM)-1 . Positive_regulation TCF20 TNF 12633744 1068271 Furthermore , treatment of HAEC with 0.5 mM DFO or NC completely inhibited *induced* activation of the [transcription factor] , specificity protein-1 (SP-1) , but only partially inhibited or did not affect activation of other transcription factors known to regulate adhesion molecule expression , i.e. , nuclear factor kappaB (NFkappaB) , activator protein-1 (AP-1) , and interferon regulatory factor-1 (IRF-1) . Positive_regulation TCF20 TNF 12810554 1102592 also *impairs* the ability of IGF-I to induce expression of a key myogenic [transcription factor] , myogenin . Positive_regulation TCF20 TNF 12890427 1117242 At the molecular level , EXPLY-37 did not inhibit the *activation* of the nuclear factor kappa B (NF-kappaB) [transcription factor] by . Positive_regulation TCF20 TNF 12893683 1135162 Ginkgo biloba extract inhibits *induced* reactive oxygen species generation , [transcription factor] activation , and cell adhesion molecule expression in human aortic endothelial cells . Positive_regulation TCF20 TNF 14646597 1173179 *induced* activation of both c-jun NH ( 2 ) -terminal kinase ( JNK ) and nuclear [transcription factor-kappaB] ( NF-kappaB ) in 3T3-L1 cells . Positive_regulation TCF20 TNF 15374848 1323849 Carvedilol inhibits induced endothelial [transcription factor] *activation* , adhesion molecule expression , and adhesiveness to human mononuclear cells . Positive_regulation TCF20 TNF 15593122 1361698 In the colons , a *inducing* [transcription factor] , LPS induced TNF-alpha factor (LITAF) , was inhibited by 1,25D3 , but not by calcium . Positive_regulation TCF20 TNF 15753227 1380078 and glucose *induced* a dose- and time dependent activation of the p38 MAP kinase , the downstream kinase mitogen- and stress activated kinase 1 , and the [transcription factor] cAMP-responsive element binding protein ( CREB ) , in EPCs . Positive_regulation TCF20 TNF 16006484 1459240 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the [transcription factor] ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TCF20 TNF 16046706 1438298 Palmitate activates the NF-kappaB [transcription factor] and *induces* IL-6 and expression in 3T3-L1 adipocytes . Positive_regulation TCF20 TNF 16338458 1503934 EMSA indicated *induced* binding of the inflammatory [transcription factor] to an NFkappaB consensus sequence and to the NFkappaB recognition site located in the PAI-1 promoter . Positive_regulation TCF20 TNF 16978650 1633539 Peptide YY reverses *induced* [transcription factor] binding of interferon regulatory factor-1 and p53 in pancreatic acinar cells . Positive_regulation TCF20 TNF 17035338 1674529 Taken together , our data suggest that the produced in response to IFN-gamma is *required* for iNOS induction by activating NF-kappaB [transcription factor] . Positive_regulation TCF20 TNF 17210691 1681510 The survival mechanism requires nuclear factor-kappaB (NF-kappaB) [transcription factor] activity , which is strongly *induced* by in these cells . Positive_regulation TCF20 TNF 17449583 1730003 Quercetin inhibits *induced* NF-kappaB [transcription factor] recruitment to proinflammatory gene promoters in murine intestinal epithelial cells . Positive_regulation TCF20 TNF 18094051 1869005 We find that NGF can *induce* synthesis through the nuclear factor-kappaB [transcription factor] . Positive_regulation TCF20 TNF 19138739 2037791 We examined whether or not 1alpha,25- ( OH ) ( 2 ) D ( 3 ) inhibits the induced *activation* of nuclear [transcription factor-kappaB] ( NF-kappaB ) , which is essential for the expression of proinflammatory cytokines in HCAEC , by ELISA . Positive_regulation TCF20 TNF 20133051 2242216 In the search of the molecular mechanisms responsible for the sensitization effect of chrysin , we discovered that such sensitization is closely associated with the inhibitory effect of chrysin on *mediated* nuclear [transcription factor-kappaB] ( NF-kappaB ) activation . Positive_regulation TCF20 TNF 20617556 2286546 Overexpression of the p65/RelA subunit of NF-kappaB , a *activated* inflammatory [transcription factor] , in A7r5 cells , upregulated SIRT1 mRNA and protein expression as well as SIRT1 promoter activity , while knockdown of endogenous p65/RelA expression by RNAi not only led to a decrease in SIRT1 's basal protein expression and promoter activity , but almost abolished the TNF-alpha induced elevation of SIRT1 protein expression and SIRT1 promoter activity . Positive_regulation TCF20 TNF 2104232 150538 *induces* binding of the NF-kappa B [transcription factor] to a high-affinity kappa B element in the TNF-beta promoter . Positive_regulation TCF20 TNF 21389273 2443503 Functionally , TNF-a stimulated H ( 2 ) O ( 2 ) production was also blocked by MCD and DES ( 194.6 ± 15.4 % vs. 90.6 ± 15.9 % and 148.8 ± 20.4 % ) , and the *activation* of the pivotal proinflammatory [transcription factor] , NF-?B , by was reversed by MCD and DES as well as by small interfering RNAs of Duox1 or ASMase . Positive_regulation TCF20 TNF 21541574 407727 These results are in contrast to those reported for the murine p53 gene , whose promoter is *induced* by through activation of the NF-kappa B [transcription factor] . Positive_regulation TCF20 TNF 8798568 381632 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by interleukin-1beta plus , and its full induction *requires* the presence of the [transcription factor] , c-FOS . Positive_regulation TCF20 TNF 9582369 504183 Overexpression of manganese superoxide dismutase suppresses *induced* apoptosis and activation of nuclear [transcription factor-kappaB] and activated protein-1 . Positive_regulation TCF20 TNF 9794740 543101 To determine whether the [transcription factor] nuclear factor-kappaB mediated expression of these genes involved in the inflammatory *response* of endothelial cells to , by using transcription factor decoy oligodeoxynucleotides . Positive_regulation TCF20 TNF 9950608 589775 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to interleukin-1beta (IL-1beta) , , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Positive_regulation TCF20 TP63 21741828 2599102 In this study we show that *induces* the expression of the basal epithelial [transcription factor] , Basonuclin 1 . Positive_regulation TCF20 WNT7A 11782388 900386 Coculture experiments demonstrated that Wnt-1 , but not Wnt-5A and , *activated* the [TCF] reporter gene . Positive_regulation TCF20 WNT7A 17431004 1748943 *stimulated* a [TCF/LEF-luciferase] reporter activity in ovine trophectoderm cells that was inhibited by dominant negative TCF and Sfrp2 ( secreted FZD related protein 2 ) . Positive_regulation TCF20 ZFP57 19234145 2072161 The other was the 5 ' noncoding region of a [transcription factor] , Zfp423 , which *induced* aberrant expression . Positive_regulation TCF21 ADRB2 15024018 1243844 To identify the mechanism responsible for this effect , we determined whether CD86 and/or stimulation *regulated* [transcription factor] expression and binding to the 3'-IgH enhancer in vitro and in vivo . Positive_regulation TCF21 AXIN2 11809808 906683 [Wnt/beta-catenin/Tcf] signaling *induces* the transcription of , a negative regulator of the signaling pathway . Positive_regulation TCF21 CCND1 14706452 1196352 The strong binding of E2F1 and NFkappaB is especially noteworthy , because the former [transcription factor] is *regulated* by , a downstream target of beta-catenin/TCF/LEF signaling , whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways . Positive_regulation TCF21 CCND1 15893541 1407591 The increased protein level was *induced* through activation of the [transcription factor] , nuclear factor kB ( NFkappaB ) , in the NHBE cells . Positive_regulation TCF21 CCND1 23135283 2707309 We find that knockdown of PAX2 inhibits the activity of AP-1 , a [transcription factor] that *induces* expression , implying that PAX2 induces cyclin D1 through AP-1 . Positive_regulation TCF21 CCND1 24979278 2947643 Thus , full activation of promoter activity *requires* ß-catenin activation of [TCF-lef] and stabilization of specific p120 catenin isoforms to relieve the repression of KAISO . Positive_regulation TCF21 CCND1 7970707 280067 *Activation* of the E2F [transcription factor] by is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation TCF21 CTGF 15601748 1361750 K252a , a known selective inhibitor of Trk , blocked this phosphorylation , CTGF induced activation of signaling proteins , and dependent *induction* of the [transcription factor] TGF-beta-inducible early gene in HMC . Positive_regulation TCF21 EPHB2 11784711 922012 Superoxide mediates shock wave induction of *dependent* osteogenic [transcription factor] ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors . Positive_regulation TCF21 EPHB2 11880483 919400 BDNF-LTP was further coupled to *dependent* phosphorylation of the [transcription factor] cAMP response element binding protein . Positive_regulation TCF21 EPHB2 15089040 1237819 Several reports indicate that the activation of extracellular signal regulated kinase ( ) *induces* microphthalmia associated [transcription factor] ( MITF ) degradation . Positive_regulation TCF21 EPHB2 15253728 1271684 *induces* increases in activator protein-1 (AP-1) [transcription factor] activity which may augment mesangial cell proliferation and ECM protein production . Positive_regulation TCF21 EPHB2 17117479 1677438 Finally , we show that activated *induced* increased expression of the Egr-1 [transcription factor] , which then bound to the promoter region of p35 . Positive_regulation TCF21 EPHB2 19910471 2189315 Active *increases* expression and activity of the c-Jun [transcription factor] , linking ERK and Jun N-terminal kinase (JNK) cascades . Positive_regulation TCF21 EPHB2 21144616 2419293 Receptors that belong to the family of death-receptors including TNF receptor-1 (TNF-R1) , CD95 ( Fas , APO-1 ) and TRAIL receptors ( TRAIL-R1 , TRAIL R2/DR4/DR5 ) transduce signals resulting in entirely different biological outcomes : They promote cell death via apoptosis but are also capable of inducing anti-apoptotic signals through the [transcription factor] nuclear factor NF-?B or *activation* of the proliferative protein kinase cascade resulting in cell protection and tissue regeneration . Positive_regulation TCF21 EPHB2 21890597 2506384 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and *dependent* activation of the CCAAT/enhancer binding protein beta [transcription factor] independent of p53 . Positive_regulation TCF21 EPHB2 24085800 2902613 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of and *activation* of Ets-1 [transcription factor] . Positive_regulation TCF21 EPHB2 8657129 364841 Analysis of the *stimulated* ETS [transcription factor] ER81 . Positive_regulation TCF21 FBXO32 18367868 1898773 FoxO3 [transcription factor] causes marked atrophy in adult skeletal muscle and *induces* the muscle-specific ubiquitin ligase ( 1 ) In addition , we recently reported that FoxO3 is necessary and sufficient for the induction of autophagy in skeletal muscle . Positive_regulation TCF21 HBEGF 23909989 2861564 Heparin-binding-epidermal growth factor ( ) down-regulates Claudin-3 expression , but *enhances* [transcription factor] Snail expression . Positive_regulation TCF21 IL1B 10816656 580255 Since the molecular basis of these antiinflammatory effects is not well known , the influence of alpha-MSH on *induced* chemokine production and [transcription factor] activation was investigated in human keratinocytes . Positive_regulation TCF21 IL1B 15217752 1263818 However , the contribution by p38 to the induction of inducible nitric oxide synthase (iNOS) and apoptosis is independent of NF-kappaB nuclear translocation since SB203580 does not prevent *induced* DNA binding of this [transcription factor] . Positive_regulation TCF21 IL1B 16326073 1553769 induced NF-kappaB activation in Caco-2 cells , *promoting* the binding of this [transcription factor] to DNA and increasing NF-kappaB dependent transcription . Positive_regulation TCF21 IL1B 16569740 1568485 OTR promoter contains putative [transcription factor] binding sites for activating protein-1 (AP-1) , CCAAT/enhancer binding protein (C/EBP) , and nuclear factor-kappaB (NF-kappaB) , which may be *activated* by , whose concentrations increase with labor . Positive_regulation TCF21 IL1B 16855208 1632218 The induced expression of human prostaglandin F2alpha receptor messenger RNA in human myometrial derived ULTR cells *requires* the [transcription factor] , NFkappaB . Positive_regulation TCF21 IL1B 18996492 2016031 Our results revealed that IL-1beta induced PBEF expression in pulmonary vascular endothelial cells at the transcriptional level and a -1535 T-variant in the human PBEF gene promoter significantly attenuated its binding to an *induced* unknown [transcription factor] . Positive_regulation TCF21 IL1B 8626526 360406 [Transcription factor] binding to the ATF/cAMP-responsive element consensus sequence was *increased* 4-5-fold by acetylsphingosine , PMA , or , whereas binding to the CCAAT/enhancer binding protein and AP-1 elements was found to be only slightly stimulated by these three agents . Positive_regulation TCF21 IL1B 8798568 381635 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by plus tumor necrosis factor-alpha , and its full induction *requires* the presence of the [transcription factor] , c-FOS . Positive_regulation TCF21 IL1B 9950608 589780 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to , tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Positive_regulation TCF21 ITGB2 15886116 1406823 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , *activation* of the NF-kappaB [transcription factor] , inside-out activation of the integrin , TCR clustering , and polarisation of the T cell . Positive_regulation TCF21 JAG1 16973960 1673628 and Delta-1 equally *activated* CBF-1/RBPJkappa [transcription factor] , which is a major Notch target . Positive_regulation TCF21 JAG1 17568183 1815676 [WNT-beta-catenin-TCF/LEF] signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , and DKK1 genes . Positive_regulation TCF21 NGFR 7536747 300276 In the case of purified Schwann cells , treatment with TGF-beta 1 increases their proliferation , and it promotes a pre- or nonmyelinating Schwann cell phenotype characterized by increased NCAM expression , decreased expression , inhibition of the forskolin mediated induction of the myelin protein P0 , and *induction* of the Schwann cell [transcription factor] suppressed cAMP-inducible POU protein . Positive_regulation TCF21 PTGER2 11706038 896747 We now report that the and EP(4) prostanoid receptors , which couple to Galpha ( s ) , also *activate* [Tcf/Lef] signaling . Positive_regulation TCF21 TCN1 18501609 1928130 Therefore , deficient may *lead* to abnormal expression of [TCF] . Positive_regulation TCF21 TLR7 19122179 2037149 signaling via p38 *led* to phosphorylation and activation of the transcription factor Microphthalmia [transcription factor] , acting at E-box elements in the Ctsk promoter . Positive_regulation TCF21 TNF 10075082 594843 Suppression of *activated* nuclear [transcription factor-kappaB] , activator protein-1 , c-Jun N-terminal kinase , and apoptosis by beta-lapachone . Positive_regulation TCF21 TNF 11093734 755015 binding to the TNF receptor (TNFR) initiates apoptosis and simultaneously *activates* the [transcription factor] , nuclear factor-kappaB (NF-kappaB) , which suppresses apoptosis by an unknown mechanism . Positive_regulation TCF21 TNF 11572998 864820 This study examines the effect of a triterpene mixture ( F094 ) and a single molecular species ( avicin G ) isolated from the mixture on induced *activation* of nuclear [transcription factor-kappaB] ( NF-kappaB ) in Jurkat cells ( human T cell leukemia ) . Positive_regulation TCF21 TNF 12091427 960128 Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB , whereas potently *induced* this [transcription factor] . Positive_regulation TCF21 TNF 12604246 1062597 Stimulation of the VECs with *led* to an increase in the DNA binding activity of the [transcription factor] , nuclear factor-kappa binding protein ( NF-kappaB ) and the induction of the adhesion molecule ( ICAM)-1 . Positive_regulation TCF21 TNF 12633744 1068272 Furthermore , treatment of HAEC with 0.5 mM DFO or NC completely inhibited induced *activation* of the [transcription factor] , specificity protein-1 (SP-1) , but only partially inhibited or did not affect activation of other transcription factors known to regulate adhesion molecule expression , i.e. , nuclear factor kappaB (NFkappaB) , activator protein-1 (AP-1) , and interferon regulatory factor-1 (IRF-1) . Positive_regulation TCF21 TNF 12810554 1102594 also *impairs* the ability of IGF-I to induce expression of a key myogenic [transcription factor] , myogenin . Positive_regulation TCF21 TNF 12890427 1117243 At the molecular level , EXPLY-37 did not inhibit the *activation* of the nuclear factor kappa B (NF-kappaB) [transcription factor] by . Positive_regulation TCF21 TNF 12893683 1135163 Ginkgo biloba extract inhibits induced reactive oxygen species generation , [transcription factor] *activation* , and cell adhesion molecule expression in human aortic endothelial cells . Positive_regulation TCF21 TNF 14646597 1173180 *induced* activation of both c-jun NH ( 2 ) -terminal kinase ( JNK ) and nuclear [transcription factor-kappaB] ( NF-kappaB ) in 3T3-L1 cells . Positive_regulation TCF21 TNF 15374848 1323850 Carvedilol inhibits *induced* endothelial [transcription factor] activation , adhesion molecule expression , and adhesiveness to human mononuclear cells . Positive_regulation TCF21 TNF 15593122 1361699 In the colons , a *inducing* [transcription factor] , LPS induced TNF-alpha factor (LITAF) , was inhibited by 1,25D3 , but not by calcium . Positive_regulation TCF21 TNF 15753227 1380079 and glucose *induced* a dose- and time dependent activation of the p38 MAP kinase , the downstream kinase mitogen- and stress activated kinase 1 , and the [transcription factor] cAMP-responsive element binding protein ( CREB ) , in EPCs . Positive_regulation TCF21 TNF 16006484 1459242 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the [transcription factor] ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TCF21 TNF 16046706 1438300 Palmitate activates the NF-kappaB [transcription factor] and *induces* IL-6 and expression in 3T3-L1 adipocytes . Positive_regulation TCF21 TNF 16338458 1503935 EMSA indicated *induced* binding of the inflammatory [transcription factor] to an NFkappaB consensus sequence and to the NFkappaB recognition site located in the PAI-1 promoter . Positive_regulation TCF21 TNF 16978650 1633540 Peptide YY reverses *induced* [transcription factor] binding of interferon regulatory factor-1 and p53 in pancreatic acinar cells . Positive_regulation TCF21 TNF 17035338 1674530 Taken together , our data suggest that the produced in response to IFN-gamma is *required* for iNOS induction by activating NF-kappaB [transcription factor] . Positive_regulation TCF21 TNF 17210691 1681511 The survival mechanism requires nuclear factor-kappaB (NF-kappaB) [transcription factor] activity , which is strongly *induced* by in these cells . Positive_regulation TCF21 TNF 17449583 1730004 Quercetin inhibits *induced* NF-kappaB [transcription factor] recruitment to proinflammatory gene promoters in murine intestinal epithelial cells . Positive_regulation TCF21 TNF 18094051 1869007 We find that NGF can *induce* synthesis through the nuclear factor-kappaB [transcription factor] . Positive_regulation TCF21 TNF 19138739 2037792 We examined whether or not 1alpha,25- ( OH ) ( 2 ) D ( 3 ) inhibits the *induced* activation of nuclear [transcription factor-kappaB] ( NF-kappaB ) , which is essential for the expression of proinflammatory cytokines in HCAEC , by ELISA . Positive_regulation TCF21 TNF 20133051 2242217 In the search of the molecular mechanisms responsible for the sensitization effect of chrysin , we discovered that such sensitization is closely associated with the inhibitory effect of chrysin on *mediated* nuclear [transcription factor-kappaB] ( NF-kappaB ) activation . Positive_regulation TCF21 TNF 20617556 2286547 Overexpression of the p65/RelA subunit of NF-kappaB , a *activated* inflammatory [transcription factor] , in A7r5 cells , upregulated SIRT1 mRNA and protein expression as well as SIRT1 promoter activity , while knockdown of endogenous p65/RelA expression by RNAi not only led to a decrease in SIRT1 's basal protein expression and promoter activity , but almost abolished the TNF-alpha induced elevation of SIRT1 protein expression and SIRT1 promoter activity . Positive_regulation TCF21 TNF 2104232 150539 *induces* binding of the NF-kappa B [transcription factor] to a high-affinity kappa B element in the TNF-beta promoter . Positive_regulation TCF21 TNF 21389273 2443504 Functionally , TNF-a stimulated H ( 2 ) O ( 2 ) production was also blocked by MCD and DES ( 194.6 ± 15.4 % vs. 90.6 ± 15.9 % and 148.8 ± 20.4 % ) , and the *activation* of the pivotal proinflammatory [transcription factor] , NF-?B , by was reversed by MCD and DES as well as by small interfering RNAs of Duox1 or ASMase . Positive_regulation TCF21 TNF 21541574 407728 These results are in contrast to those reported for the murine p53 gene , whose promoter is *induced* by through activation of the NF-kappa B [transcription factor] . Positive_regulation TCF21 TNF 8798568 381634 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by interleukin-1beta plus , and its full induction *requires* the presence of the [transcription factor] , c-FOS . Positive_regulation TCF21 TNF 9582369 504184 Overexpression of manganese superoxide dismutase suppresses *induced* apoptosis and activation of nuclear [transcription factor-kappaB] and activated protein-1 . Positive_regulation TCF21 TNF 9794740 543102 To determine whether the [transcription factor] nuclear factor-kappaB mediated expression of these genes involved in the inflammatory *response* of endothelial cells to , by using transcription factor decoy oligodeoxynucleotides . Positive_regulation TCF21 TNF 9950608 589778 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to interleukin-1beta (IL-1beta) , , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Positive_regulation TCF21 TP63 21741828 2599103 In this study we show that *induces* the expression of the basal epithelial [transcription factor] , Basonuclin 1 . Positive_regulation TCF21 WNT7A 11782388 900389 Coculture experiments demonstrated that Wnt-1 , but not Wnt-5A and , *activated* the [TCF] reporter gene . Positive_regulation TCF21 WNT7A 17431004 1748944 *stimulated* a [TCF/LEF-luciferase] reporter activity in ovine trophectoderm cells that was inhibited by dominant negative TCF and Sfrp2 ( secreted FZD related protein 2 ) . Positive_regulation TCF21 ZFP57 19234145 2072179 The other was the 5 ' noncoding region of a [transcription factor] , Zfp423 , which *induced* aberrant expression . Positive_regulation TCF23 ADRB2 15024018 1243852 To identify the mechanism responsible for this effect , we determined whether CD86 and/or stimulation *regulated* [transcription factor] expression and binding to the 3'-IgH enhancer in vitro and in vivo . Positive_regulation TCF23 AXIN2 11809808 906694 [Wnt/beta-catenin/Tcf] signaling *induces* the transcription of , a negative regulator of the signaling pathway . Positive_regulation TCF23 CCND1 14706452 1196356 The strong binding of E2F1 and NFkappaB is especially noteworthy , because the former [transcription factor] is *regulated* by , a downstream target of beta-catenin/TCF/LEF signaling , whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways . Positive_regulation TCF23 CCND1 15893541 1407595 The increased protein level was *induced* through activation of the [transcription factor] , nuclear factor kB ( NFkappaB ) , in the NHBE cells . Positive_regulation TCF23 CCND1 23135283 2707314 We find that knockdown of PAX2 inhibits the activity of AP-1 , a [transcription factor] that *induces* expression , implying that PAX2 induces cyclin D1 through AP-1 . Positive_regulation TCF23 CCND1 24979278 2947659 Thus , full activation of promoter activity *requires* ß-catenin activation of [TCF-lef] and stabilization of specific p120 catenin isoforms to relieve the repression of KAISO . Positive_regulation TCF23 CCND1 7970707 280087 *Activation* of the E2F [transcription factor] by is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation TCF23 CTGF 15601748 1361754 K252a , a known selective inhibitor of Trk , blocked this phosphorylation , induced *activation* of signaling proteins , and CTGF dependent induction of the [transcription factor] TGF-beta-inducible early gene in HMC . Positive_regulation TCF23 EPHB2 11784711 922016 Superoxide mediates shock wave induction of *dependent* osteogenic [transcription factor] ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors . Positive_regulation TCF23 EPHB2 11880483 919404 BDNF-LTP was further coupled to *dependent* phosphorylation of the [transcription factor] cAMP response element binding protein . Positive_regulation TCF23 EPHB2 15089040 1237823 Several reports indicate that the activation of extracellular signal regulated kinase ( ) *induces* microphthalmia associated [transcription factor] ( MITF ) degradation . Positive_regulation TCF23 EPHB2 15253728 1271688 *induces* increases in activator protein-1 (AP-1) [transcription factor] activity which may augment mesangial cell proliferation and ECM protein production . Positive_regulation TCF23 EPHB2 17117479 1677442 Finally , we show that activated *induced* increased expression of the Egr-1 [transcription factor] , which then bound to the promoter region of p35 . Positive_regulation TCF23 EPHB2 19910471 2189319 Active *increases* expression and activity of the c-Jun [transcription factor] , linking ERK and Jun N-terminal kinase (JNK) cascades . Positive_regulation TCF23 EPHB2 21144616 2419349 Receptors that belong to the family of death-receptors including TNF receptor-1 (TNF-R1) , CD95 ( Fas , APO-1 ) and TRAIL receptors ( TRAIL-R1 , TRAIL R2/DR4/DR5 ) transduce signals resulting in entirely different biological outcomes : They promote cell death via apoptosis but are also capable of inducing anti-apoptotic signals through the [transcription factor] nuclear factor NF-?B or *activation* of the proliferative protein kinase cascade resulting in cell protection and tissue regeneration . Positive_regulation TCF23 EPHB2 21890597 2506390 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and dependent *activation* of the CCAAT/enhancer binding protein beta [transcription factor] independent of p53 . Positive_regulation TCF23 EPHB2 24085800 2902617 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of and *activation* of Ets-1 [transcription factor] . Positive_regulation TCF23 EPHB2 8657129 364845 Analysis of the *stimulated* ETS [transcription factor] ER81 . Positive_regulation TCF23 FBXO32 18367868 1898788 FoxO3 [transcription factor] causes marked atrophy in adult skeletal muscle and *induces* the muscle-specific ubiquitin ligase ( 1 ) In addition , we recently reported that FoxO3 is necessary and sufficient for the induction of autophagy in skeletal muscle . Positive_regulation TCF23 HBEGF 23909989 2861572 Heparin-binding-epidermal growth factor ( ) down-regulates Claudin-3 expression , but *enhances* [transcription factor] Snail expression . Positive_regulation TCF23 IL1B 10816656 580259 Since the molecular basis of these antiinflammatory effects is not well known , the influence of alpha-MSH on *induced* chemokine production and [transcription factor] activation was investigated in human keratinocytes . Positive_regulation TCF23 IL1B 15217752 1263822 However , the contribution by p38 to the induction of inducible nitric oxide synthase (iNOS) and apoptosis is independent of NF-kappaB nuclear translocation since SB203580 does not prevent *induced* DNA binding of this [transcription factor] . Positive_regulation TCF23 IL1B 16326073 1553781 induced NF-kappaB activation in Caco-2 cells , *promoting* the binding of this [transcription factor] to DNA and increasing NF-kappaB dependent transcription . Positive_regulation TCF23 IL1B 16569740 1568489 OTR promoter contains putative [transcription factor] binding sites for activating protein-1 (AP-1) , CCAAT/enhancer binding protein (C/EBP) , and nuclear factor-kappaB (NF-kappaB) , which may be *activated* by , whose concentrations increase with labor . Positive_regulation TCF23 IL1B 16855208 1632222 The induced expression of human prostaglandin F2alpha receptor messenger RNA in human myometrial derived ULTR cells *requires* the [transcription factor] , NFkappaB . Positive_regulation TCF23 IL1B 18996492 2016035 Our results revealed that IL-1beta induced PBEF expression in pulmonary vascular endothelial cells at the transcriptional level and a -1535 T-variant in the human PBEF gene promoter significantly attenuated its binding to an *induced* unknown [transcription factor] . Positive_regulation TCF23 IL1B 8626526 360410 [Transcription factor] binding to the ATF/cAMP-responsive element consensus sequence was *increased* 4-5-fold by acetylsphingosine , PMA , or , whereas binding to the CCAAT/enhancer binding protein and AP-1 elements was found to be only slightly stimulated by these three agents . Positive_regulation TCF23 IL1B 8798568 381654 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by plus tumor necrosis factor-alpha , and its full induction *requires* the presence of the [transcription factor] , c-FOS . Positive_regulation TCF23 IL1B 9950608 589792 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to , tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Positive_regulation TCF23 ITGB2 15886116 1406831 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , *activation* of the NF-kappaB [transcription factor] , inside-out activation of the integrin , TCR clustering , and polarisation of the T cell . Positive_regulation TCF23 JAG1 16973960 1673636 and Delta-1 equally *activated* CBF-1/RBPJkappa [transcription factor] , which is a major Notch target . Positive_regulation TCF23 JAG1 17568183 1815728 [WNT-beta-catenin-TCF/LEF] signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , and DKK1 genes . Positive_regulation TCF23 NGFR 7536747 300284 In the case of purified Schwann cells , treatment with TGF-beta 1 increases their proliferation , and it promotes a pre- or nonmyelinating Schwann cell phenotype characterized by increased NCAM expression , decreased expression , inhibition of the forskolin mediated induction of the myelin protein P0 , and *induction* of the Schwann cell [transcription factor] suppressed cAMP-inducible POU protein . Positive_regulation TCF23 PTGER2 11706038 896755 We now report that the and EP(4) prostanoid receptors , which couple to Galpha ( s ) , also *activate* [Tcf/Lef] signaling . Positive_regulation TCF23 TCN1 18501609 1928134 Therefore , deficient may *lead* to abnormal expression of [TCF] . Positive_regulation TCF23 TLR7 19122179 2037189 signaling via p38 *led* to phosphorylation and activation of the transcription factor Microphthalmia [transcription factor] , acting at E-box elements in the Ctsk promoter . Positive_regulation TCF23 TNF 10075082 594847 Suppression of *activated* nuclear [transcription factor-kappaB] , activator protein-1 , c-Jun N-terminal kinase , and apoptosis by beta-lapachone . Positive_regulation TCF23 TNF 11093734 755019 binding to the TNF receptor (TNFR) initiates apoptosis and simultaneously *activates* the [transcription factor] , nuclear factor-kappaB (NF-kappaB) , which suppresses apoptosis by an unknown mechanism . Positive_regulation TCF23 TNF 11572998 864824 This study examines the effect of a triterpene mixture ( F094 ) and a single molecular species ( avicin G ) isolated from the mixture on induced *activation* of nuclear [transcription factor-kappaB] ( NF-kappaB ) in Jurkat cells ( human T cell leukemia ) . Positive_regulation TCF23 TNF 12091427 960143 Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB , whereas potently *induced* this [transcription factor] . Positive_regulation TCF23 TNF 12604246 1062601 Stimulation of the VECs with *led* to an increase in the DNA binding activity of the [transcription factor] , nuclear factor-kappa binding protein ( NF-kappaB ) and the induction of the adhesion molecule ( ICAM)-1 . Positive_regulation TCF23 TNF 12633744 1068276 Furthermore , treatment of HAEC with 0.5 mM DFO or NC completely inhibited *induced* activation of the [transcription factor] , specificity protein-1 (SP-1) , but only partially inhibited or did not affect activation of other transcription factors known to regulate adhesion molecule expression , i.e. , nuclear factor kappaB (NFkappaB) , activator protein-1 (AP-1) , and interferon regulatory factor-1 (IRF-1) . Positive_regulation TCF23 TNF 12810554 1102602 also *impairs* the ability of IGF-I to induce expression of a key myogenic [transcription factor] , myogenin . Positive_regulation TCF23 TNF 12890427 1117258 At the molecular level , EXPLY-37 did not inhibit the *activation* of the nuclear factor kappa B (NF-kappaB) [transcription factor] by . Positive_regulation TCF23 TNF 12893683 1135168 Ginkgo biloba extract inhibits *induced* reactive oxygen species generation , [transcription factor] activation , and cell adhesion molecule expression in human aortic endothelial cells . Positive_regulation TCF23 TNF 14646597 1173195 *induced* activation of both c-jun NH ( 2 ) -terminal kinase ( JNK ) and nuclear [transcription factor-kappaB] ( NF-kappaB ) in 3T3-L1 cells . Positive_regulation TCF23 TNF 15374848 1323854 Carvedilol inhibits induced endothelial [transcription factor] *activation* , adhesion molecule expression , and adhesiveness to human mononuclear cells . Positive_regulation TCF23 TNF 15593122 1361704 In the colons , a *inducing* [transcription factor] , LPS induced TNF-alpha factor (LITAF) , was inhibited by 1,25D3 , but not by calcium . Positive_regulation TCF23 TNF 15753227 1380084 and glucose *induced* a dose- and time dependent activation of the p38 MAP kinase , the downstream kinase mitogen- and stress activated kinase 1 , and the [transcription factor] cAMP-responsive element binding protein ( CREB ) , in EPCs . Positive_regulation TCF23 TNF 16006484 1459263 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the [transcription factor] ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TCF23 TNF 16046706 1438319 Palmitate activates the NF-kappaB [transcription factor] and *induces* IL-6 and expression in 3T3-L1 adipocytes . Positive_regulation TCF23 TNF 16338458 1503939 EMSA indicated *induced* binding of the inflammatory [transcription factor] to an NFkappaB consensus sequence and to the NFkappaB recognition site located in the PAI-1 promoter . Positive_regulation TCF23 TNF 16978650 1633545 Peptide YY reverses *induced* [transcription factor] binding of interferon regulatory factor-1 and p53 in pancreatic acinar cells . Positive_regulation TCF23 TNF 17035338 1674546 Taken together , our data suggest that the produced in response to IFN-gamma is *required* for iNOS induction by activating NF-kappaB [transcription factor] . Positive_regulation TCF23 TNF 17210691 1681515 The survival mechanism requires nuclear factor-kappaB (NF-kappaB) [transcription factor] activity , which is strongly *induced* by in these cells . Positive_regulation TCF23 TNF 17449583 1730008 Quercetin inhibits *induced* NF-kappaB [transcription factor] recruitment to proinflammatory gene promoters in murine intestinal epithelial cells . Positive_regulation TCF23 TNF 18094051 1869016 We find that NGF can *induce* synthesis through the nuclear factor-kappaB [transcription factor] . Positive_regulation TCF23 TNF 19138739 2037796 We examined whether or not 1alpha,25- ( OH ) ( 2 ) D ( 3 ) inhibits the *induced* activation of nuclear [transcription factor-kappaB] ( NF-kappaB ) , which is essential for the expression of proinflammatory cytokines in HCAEC , by ELISA . Positive_regulation TCF23 TNF 20133051 2242221 In the search of the molecular mechanisms responsible for the sensitization effect of chrysin , we discovered that such sensitization is closely associated with the inhibitory effect of chrysin on *mediated* nuclear [transcription factor-kappaB] ( NF-kappaB ) activation . Positive_regulation TCF23 TNF 20617556 2286551 Overexpression of the p65/RelA subunit of NF-kappaB , a *activated* inflammatory [transcription factor] , in A7r5 cells , upregulated SIRT1 mRNA and protein expression as well as SIRT1 promoter activity , while knockdown of endogenous p65/RelA expression by RNAi not only led to a decrease in SIRT1 's basal protein expression and promoter activity , but almost abolished the TNF-alpha induced elevation of SIRT1 protein expression and SIRT1 promoter activity . Positive_regulation TCF23 TNF 2104232 150543 *induces* binding of the NF-kappa B [transcription factor] to a high-affinity kappa B element in the TNF-beta promoter . Positive_regulation TCF23 TNF 21389273 2443519 Functionally , TNF-a stimulated H ( 2 ) O ( 2 ) production was also blocked by MCD and DES ( 194.6 ± 15.4 % vs. 90.6 ± 15.9 % and 148.8 ± 20.4 % ) , and the *activation* of the pivotal proinflammatory [transcription factor] , NF-?B , by was reversed by MCD and DES as well as by small interfering RNAs of Duox1 or ASMase . Positive_regulation TCF23 TNF 21541574 407732 These results are in contrast to those reported for the murine p53 gene , whose promoter is *induced* by through activation of the NF-kappa B [transcription factor] . Positive_regulation TCF23 TNF 8798568 381653 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by interleukin-1beta plus , and its full induction *requires* the presence of the [transcription factor] , c-FOS . Positive_regulation TCF23 TNF 9582369 504188 Overexpression of manganese superoxide dismutase suppresses *induced* apoptosis and activation of nuclear [transcription factor-kappaB] and activated protein-1 . Positive_regulation TCF23 TNF 9794740 543106 To determine whether the [transcription factor] nuclear factor-kappaB mediated expression of these genes involved in the inflammatory *response* of endothelial cells to , by using transcription factor decoy oligodeoxynucleotides . Positive_regulation TCF23 TNF 9950608 589790 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to interleukin-1beta (IL-1beta) , , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Positive_regulation TCF23 TP63 21741828 2599107 In this study we show that *induces* the expression of the basal epithelial [transcription factor] , Basonuclin 1 . Positive_regulation TCF23 WNT7A 11782388 900401 Coculture experiments demonstrated that Wnt-1 , but not Wnt-5A and , *activated* the [TCF] reporter gene . Positive_regulation TCF23 WNT7A 17431004 1748948 *stimulated* a [TCF/LEF-luciferase] reporter activity in ovine trophectoderm cells that was inhibited by dominant negative TCF and Sfrp2 ( secreted FZD related protein 2 ) . Positive_regulation TCF23 ZFP57 19234145 2072251 The other was the 5 ' noncoding region of a [transcription factor] , Zfp423 , which *induced* aberrant expression . Positive_regulation TCF24 ADRB2 15024018 1243856 To identify the mechanism responsible for this effect , we determined whether CD86 and/or stimulation *regulated* [transcription factor] expression and binding to the 3'-IgH enhancer in vitro and in vivo . Positive_regulation TCF24 AXIN2 11809808 906697 [Wnt/beta-catenin/Tcf] signaling *induces* the transcription of , a negative regulator of the signaling pathway . Positive_regulation TCF24 CCND1 14706452 1196358 The strong binding of E2F1 and NFkappaB is especially noteworthy , because the former [transcription factor] is *regulated* by , a downstream target of beta-catenin/TCF/LEF signaling , whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways . Positive_regulation TCF24 CCND1 15893541 1407597 The increased protein level was *induced* through activation of the [transcription factor] , nuclear factor kB ( NFkappaB ) , in the NHBE cells . Positive_regulation TCF24 CCND1 23135283 2707316 We find that knockdown of PAX2 inhibits the activity of AP-1 , a [transcription factor] that *induces* expression , implying that PAX2 induces cyclin D1 through AP-1 . Positive_regulation TCF24 CCND1 24979278 2947662 Thus , full activation of promoter activity *requires* ß-catenin activation of [TCF-lef] and stabilization of specific p120 catenin isoforms to relieve the repression of KAISO . Positive_regulation TCF24 CCND1 7970707 280107 *Activation* of the E2F [transcription factor] by is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation TCF24 CTGF 15601748 1361756 K252a , a known selective inhibitor of Trk , blocked this phosphorylation , induced *activation* of signaling proteins , and CTGF dependent induction of the [transcription factor] TGF-beta-inducible early gene in HMC . Positive_regulation TCF24 EPHB2 11784711 922018 Superoxide mediates shock wave induction of *dependent* osteogenic [transcription factor] ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors . Positive_regulation TCF24 EPHB2 11880483 919406 BDNF-LTP was further coupled to *dependent* phosphorylation of the [transcription factor] cAMP response element binding protein . Positive_regulation TCF24 EPHB2 15089040 1237825 Several reports indicate that the activation of extracellular signal regulated kinase ( ) *induces* microphthalmia associated [transcription factor] ( MITF ) degradation . Positive_regulation TCF24 EPHB2 15253728 1271690 *induces* increases in activator protein-1 (AP-1) [transcription factor] activity which may augment mesangial cell proliferation and ECM protein production . Positive_regulation TCF24 EPHB2 17117479 1677444 Finally , we show that activated *induced* increased expression of the Egr-1 [transcription factor] , which then bound to the promoter region of p35 . Positive_regulation TCF24 EPHB2 19910471 2189321 Active *increases* expression and activity of the c-Jun [transcription factor] , linking ERK and Jun N-terminal kinase (JNK) cascades . Positive_regulation TCF24 EPHB2 21144616 2419377 Receptors that belong to the family of death-receptors including TNF receptor-1 (TNF-R1) , CD95 ( Fas , APO-1 ) and TRAIL receptors ( TRAIL-R1 , TRAIL R2/DR4/DR5 ) transduce signals resulting in entirely different biological outcomes : They promote cell death via apoptosis but are also capable of inducing anti-apoptotic signals through the [transcription factor] nuclear factor NF-?B or *activation* of the proliferative protein kinase cascade resulting in cell protection and tissue regeneration . Positive_regulation TCF24 EPHB2 21890597 2506392 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and dependent *activation* of the CCAAT/enhancer binding protein beta [transcription factor] independent of p53 . Positive_regulation TCF24 EPHB2 24085800 2902619 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of and *activation* of Ets-1 [transcription factor] . Positive_regulation TCF24 EPHB2 8657129 364847 Analysis of the *stimulated* ETS [transcription factor] ER81 . Positive_regulation TCF24 FBXO32 18367868 1898790 FoxO3 [transcription factor] causes marked atrophy in adult skeletal muscle and *induces* the muscle-specific ubiquitin ligase ( 1 ) In addition , we recently reported that FoxO3 is necessary and sufficient for the induction of autophagy in skeletal muscle . Positive_regulation TCF24 HBEGF 23909989 2861576 Heparin-binding-epidermal growth factor ( ) down-regulates Claudin-3 expression , but *enhances* [transcription factor] Snail expression . Positive_regulation TCF24 IL1B 10816656 580261 Since the molecular basis of these antiinflammatory effects is not well known , the influence of alpha-MSH on *induced* chemokine production and [transcription factor] activation was investigated in human keratinocytes . Positive_regulation TCF24 IL1B 15217752 1263824 However , the contribution by p38 to the induction of inducible nitric oxide synthase (iNOS) and apoptosis is independent of NF-kappaB nuclear translocation since SB203580 does not prevent *induced* DNA binding of this [transcription factor] . Positive_regulation TCF24 IL1B 16326073 1553787 induced NF-kappaB activation in Caco-2 cells , *promoting* the binding of this [transcription factor] to DNA and increasing NF-kappaB dependent transcription . Positive_regulation TCF24 IL1B 16569740 1568492 OTR promoter contains putative [transcription factor] binding sites for activating protein-1 (AP-1) , CCAAT/enhancer binding protein (C/EBP) , and nuclear factor-kappaB (NF-kappaB) , which may be *activated* by , whose concentrations increase with labor . Positive_regulation TCF24 IL1B 16855208 1632224 The induced expression of human prostaglandin F2alpha receptor messenger RNA in human myometrial derived ULTR cells *requires* the [transcription factor] , NFkappaB . Positive_regulation TCF24 IL1B 18996492 2016037 Our results revealed that IL-1beta induced PBEF expression in pulmonary vascular endothelial cells at the transcriptional level and a -1535 T-variant in the human PBEF gene promoter significantly attenuated its binding to an *induced* unknown [transcription factor] . Positive_regulation TCF24 IL1B 8626526 360412 [Transcription factor] binding to the ATF/cAMP-responsive element consensus sequence was *increased* 4-5-fold by acetylsphingosine , PMA , or , whereas binding to the CCAAT/enhancer binding protein and AP-1 elements was found to be only slightly stimulated by these three agents . Positive_regulation TCF24 IL1B 8798568 381658 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by plus tumor necrosis factor-alpha , and its full induction *requires* the presence of the [transcription factor] , c-FOS . Positive_regulation TCF24 IL1B 9950608 589798 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to , tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Positive_regulation TCF24 ITGB2 15886116 1406835 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , *activation* of the NF-kappaB [transcription factor] , inside-out activation of the integrin , TCR clustering , and polarisation of the T cell . Positive_regulation TCF24 JAG1 16973960 1673640 and Delta-1 equally *activated* CBF-1/RBPJkappa [transcription factor] , which is a major Notch target . Positive_regulation TCF24 JAG1 17568183 1815737 [WNT-beta-catenin-TCF/LEF] signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , and DKK1 genes . Positive_regulation TCF24 NGFR 7536747 300288 In the case of purified Schwann cells , treatment with TGF-beta 1 increases their proliferation , and it promotes a pre- or nonmyelinating Schwann cell phenotype characterized by increased NCAM expression , decreased expression , inhibition of the forskolin mediated induction of the myelin protein P0 , and *induction* of the Schwann cell [transcription factor] suppressed cAMP-inducible POU protein . Positive_regulation TCF24 PTGER2 11706038 896759 We now report that the and EP(4) prostanoid receptors , which couple to Galpha ( s ) , also *activate* [Tcf/Lef] signaling . Positive_regulation TCF24 TCN1 18501609 1928136 Therefore , deficient may *lead* to abnormal expression of [TCF] . Positive_regulation TCF24 TLR7 19122179 2037209 signaling via p38 *led* to phosphorylation and activation of the transcription factor Microphthalmia [transcription factor] , acting at E-box elements in the Ctsk promoter . Positive_regulation TCF24 TNF 10075082 594849 Suppression of *activated* nuclear [transcription factor-kappaB] , activator protein-1 , c-Jun N-terminal kinase , and apoptosis by beta-lapachone . Positive_regulation TCF24 TNF 11093734 755021 binding to the TNF receptor (TNFR) initiates apoptosis and simultaneously *activates* the [transcription factor] , nuclear factor-kappaB (NF-kappaB) , which suppresses apoptosis by an unknown mechanism . Positive_regulation TCF24 TNF 11572998 864826 This study examines the effect of a triterpene mixture ( F094 ) and a single molecular species ( avicin G ) isolated from the mixture on induced *activation* of nuclear [transcription factor-kappaB] ( NF-kappaB ) in Jurkat cells ( human T cell leukemia ) . Positive_regulation TCF24 TNF 12091427 960145 Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB , whereas potently *induced* this [transcription factor] . Positive_regulation TCF24 TNF 12604246 1062603 Stimulation of the VECs with *led* to an increase in the DNA binding activity of the [transcription factor] , nuclear factor-kappa binding protein ( NF-kappaB ) and the induction of the adhesion molecule ( ICAM)-1 . Positive_regulation TCF24 TNF 12633744 1068278 Furthermore , treatment of HAEC with 0.5 mM DFO or NC completely inhibited *induced* activation of the [transcription factor] , specificity protein-1 (SP-1) , but only partially inhibited or did not affect activation of other transcription factors known to regulate adhesion molecule expression , i.e. , nuclear factor kappaB (NFkappaB) , activator protein-1 (AP-1) , and interferon regulatory factor-1 (IRF-1) . Positive_regulation TCF24 TNF 12810554 1102606 also *impairs* the ability of IGF-I to induce expression of a key myogenic [transcription factor] , myogenin . Positive_regulation TCF24 TNF 12890427 1117260 At the molecular level , EXPLY-37 did not inhibit the *activation* of the nuclear factor kappa B (NF-kappaB) [transcription factor] by . Positive_regulation TCF24 TNF 12893683 1135172 Ginkgo biloba extract inhibits *induced* reactive oxygen species generation , [transcription factor] activation , and cell adhesion molecule expression in human aortic endothelial cells . Positive_regulation TCF24 TNF 14646597 1173197 *induced* activation of both c-jun NH ( 2 ) -terminal kinase ( JNK ) and nuclear [transcription factor-kappaB] ( NF-kappaB ) in 3T3-L1 cells . Positive_regulation TCF24 TNF 15374848 1323856 Carvedilol inhibits induced endothelial [transcription factor] *activation* , adhesion molecule expression , and adhesiveness to human mononuclear cells . Positive_regulation TCF24 TNF 15593122 1361706 In the colons , a *inducing* [transcription factor] , LPS induced TNF-alpha factor (LITAF) , was inhibited by 1,25D3 , but not by calcium . Positive_regulation TCF24 TNF 15753227 1380088 and glucose *induced* a dose- and time dependent activation of the p38 MAP kinase , the downstream kinase mitogen- and stress activated kinase 1 , and the [transcription factor] cAMP-responsive element binding protein ( CREB ) , in EPCs . Positive_regulation TCF24 TNF 16006484 1459267 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the [transcription factor] ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TCF24 TNF 16046706 1438323 Palmitate activates the NF-kappaB [transcription factor] and *induces* IL-6 and expression in 3T3-L1 adipocytes . Positive_regulation TCF24 TNF 16338458 1503941 EMSA indicated *induced* binding of the inflammatory [transcription factor] to an NFkappaB consensus sequence and to the NFkappaB recognition site located in the PAI-1 promoter . Positive_regulation TCF24 TNF 16978650 1633547 Peptide YY reverses *induced* [transcription factor] binding of interferon regulatory factor-1 and p53 in pancreatic acinar cells . Positive_regulation TCF24 TNF 17035338 1674548 Taken together , our data suggest that the produced in response to IFN-gamma is *required* for iNOS induction by activating NF-kappaB [transcription factor] . Positive_regulation TCF24 TNF 17210691 1681517 The survival mechanism requires nuclear factor-kappaB (NF-kappaB) [transcription factor] activity , which is strongly *induced* by in these cells . Positive_regulation TCF24 TNF 17449583 1730010 Quercetin inhibits *induced* NF-kappaB [transcription factor] recruitment to proinflammatory gene promoters in murine intestinal epithelial cells . Positive_regulation TCF24 TNF 18094051 1869020 We find that NGF can *induce* synthesis through the nuclear factor-kappaB [transcription factor] . Positive_regulation TCF24 TNF 19138739 2037798 We examined whether or not 1alpha,25- ( OH ) ( 2 ) D ( 3 ) inhibits the *induced* activation of nuclear [transcription factor-kappaB] ( NF-kappaB ) , which is essential for the expression of proinflammatory cytokines in HCAEC , by ELISA . Positive_regulation TCF24 TNF 20133051 2242223 In the search of the molecular mechanisms responsible for the sensitization effect of chrysin , we discovered that such sensitization is closely associated with the inhibitory effect of chrysin on *mediated* nuclear [transcription factor-kappaB] ( NF-kappaB ) activation . Positive_regulation TCF24 TNF 20617556 2286553 Overexpression of the p65/RelA subunit of NF-kappaB , a *activated* inflammatory [transcription factor] , in A7r5 cells , upregulated SIRT1 mRNA and protein expression as well as SIRT1 promoter activity , while knockdown of endogenous p65/RelA expression by RNAi not only led to a decrease in SIRT1 's basal protein expression and promoter activity , but almost abolished the TNF-alpha induced elevation of SIRT1 protein expression and SIRT1 promoter activity . Positive_regulation TCF24 TNF 2104232 150545 *induces* binding of the NF-kappa B [transcription factor] to a high-affinity kappa B element in the TNF-beta promoter . Positive_regulation TCF24 TNF 21389273 2443521 Functionally , TNF-a stimulated H ( 2 ) O ( 2 ) production was also blocked by MCD and DES ( 194.6 ± 15.4 % vs. 90.6 ± 15.9 % and 148.8 ± 20.4 % ) , and the *activation* of the pivotal proinflammatory [transcription factor] , NF-?B , by was reversed by MCD and DES as well as by small interfering RNAs of Duox1 or ASMase . Positive_regulation TCF24 TNF 21541574 407734 These results are in contrast to those reported for the murine p53 gene , whose promoter is *induced* by through activation of the NF-kappa B [transcription factor] . Positive_regulation TCF24 TNF 8798568 381657 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by interleukin-1beta plus , and its full induction *requires* the presence of the [transcription factor] , c-FOS . Positive_regulation TCF24 TNF 9582369 504190 Overexpression of manganese superoxide dismutase suppresses *induced* apoptosis and activation of nuclear [transcription factor-kappaB] and activated protein-1 . Positive_regulation TCF24 TNF 9794740 543108 To determine whether the [transcription factor] nuclear factor-kappaB mediated expression of these genes involved in the inflammatory *response* of endothelial cells to , by using transcription factor decoy oligodeoxynucleotides . Positive_regulation TCF24 TNF 9950608 589796 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to interleukin-1beta (IL-1beta) , , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Positive_regulation TCF24 TP63 21741828 2599109 In this study we show that *induces* the expression of the basal epithelial [transcription factor] , Basonuclin 1 . Positive_regulation TCF24 WNT7A 11782388 900407 Coculture experiments demonstrated that Wnt-1 , but not Wnt-5A and , *activated* the [TCF] reporter gene . Positive_regulation TCF24 WNT7A 17431004 1748950 *stimulated* a [TCF/LEF-luciferase] reporter activity in ovine trophectoderm cells that was inhibited by dominant negative TCF and Sfrp2 ( secreted FZD related protein 2 ) . Positive_regulation TCF24 ZFP57 19234145 2072287 The other was the 5 ' noncoding region of a [transcription factor] , Zfp423 , which *induced* aberrant expression . Positive_regulation TCF25 ADRB2 15024018 1243854 To identify the mechanism responsible for this effect , we determined whether CD86 and/or stimulation *regulated* [transcription factor] expression and binding to the 3'-IgH enhancer in vitro and in vivo . Positive_regulation TCF25 AXIN2 11809808 906696 [Wnt/beta-catenin/Tcf] signaling *induces* the transcription of , a negative regulator of the signaling pathway . Positive_regulation TCF25 CCND1 14706452 1196357 The strong binding of E2F1 and NFkappaB is especially noteworthy , because the former [transcription factor] is *regulated* by , a downstream target of beta-catenin/TCF/LEF signaling , whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways . Positive_regulation TCF25 CCND1 15893541 1407596 The increased protein level was *induced* through activation of the [transcription factor] , nuclear factor kB ( NFkappaB ) , in the NHBE cells . Positive_regulation TCF25 CCND1 23135283 2707315 We find that knockdown of PAX2 inhibits the activity of AP-1 , a [transcription factor] that *induces* expression , implying that PAX2 induces cyclin D1 through AP-1 . Positive_regulation TCF25 CCND1 24979278 2947661 Thus , full activation of promoter activity *requires* ß-catenin activation of [TCF-lef] and stabilization of specific p120 catenin isoforms to relieve the repression of KAISO . Positive_regulation TCF25 CCND1 7970707 280093 *Activation* of the E2F [transcription factor] by is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation TCF25 CTGF 15601748 1361755 K252a , a known selective inhibitor of Trk , blocked this phosphorylation , CTGF induced activation of signaling proteins , and dependent *induction* of the [transcription factor] TGF-beta-inducible early gene in HMC . Positive_regulation TCF25 EPHB2 11784711 922017 Superoxide mediates shock wave induction of *dependent* osteogenic [transcription factor] ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors . Positive_regulation TCF25 EPHB2 11880483 919405 BDNF-LTP was further coupled to *dependent* phosphorylation of the [transcription factor] cAMP response element binding protein . Positive_regulation TCF25 EPHB2 15089040 1237824 Several reports indicate that the activation of extracellular signal regulated kinase ( ) *induces* microphthalmia associated [transcription factor] ( MITF ) degradation . Positive_regulation TCF25 EPHB2 15253728 1271689 *induces* increases in activator protein-1 (AP-1) [transcription factor] activity which may augment mesangial cell proliferation and ECM protein production . Positive_regulation TCF25 EPHB2 17117479 1677443 Finally , we show that activated *induced* increased expression of the Egr-1 [transcription factor] , which then bound to the promoter region of p35 . Positive_regulation TCF25 EPHB2 19910471 2189320 Active *increases* expression and activity of the c-Jun [transcription factor] , linking ERK and Jun N-terminal kinase (JNK) cascades . Positive_regulation TCF25 EPHB2 21144616 2419363 Receptors that belong to the family of death-receptors including TNF receptor-1 (TNF-R1) , CD95 ( Fas , APO-1 ) and TRAIL receptors ( TRAIL-R1 , TRAIL R2/DR4/DR5 ) transduce signals resulting in entirely different biological outcomes : They promote cell death via apoptosis but are also capable of inducing anti-apoptotic signals through the [transcription factor] nuclear factor NF-?B or *activation* of the proliferative protein kinase cascade resulting in cell protection and tissue regeneration . Positive_regulation TCF25 EPHB2 21890597 2506391 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and *dependent* activation of the CCAAT/enhancer binding protein beta [transcription factor] independent of p53 . Positive_regulation TCF25 EPHB2 24085800 2902618 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of and *activation* of Ets-1 [transcription factor] . Positive_regulation TCF25 EPHB2 8657129 364846 Analysis of the *stimulated* ETS [transcription factor] ER81 . Positive_regulation TCF25 FBXO32 18367868 1898789 FoxO3 [transcription factor] causes marked atrophy in adult skeletal muscle and *induces* the muscle-specific ubiquitin ligase ( 1 ) In addition , we recently reported that FoxO3 is necessary and sufficient for the induction of autophagy in skeletal muscle . Positive_regulation TCF25 HBEGF 23909989 2861574 Heparin-binding-epidermal growth factor ( ) down-regulates Claudin-3 expression , but *enhances* [transcription factor] Snail expression . Positive_regulation TCF25 IL1B 10816656 580260 Since the molecular basis of these antiinflammatory effects is not well known , the influence of alpha-MSH on induced chemokine production and [transcription factor] *activation* was investigated in human keratinocytes . Positive_regulation TCF25 IL1B 15217752 1263823 However , the contribution by p38 to the induction of inducible nitric oxide synthase (iNOS) and apoptosis is independent of NF-kappaB nuclear translocation since SB203580 does not prevent *induced* DNA binding of this [transcription factor] . Positive_regulation TCF25 IL1B 16326073 1553784 induced NF-kappaB activation in Caco-2 cells , *promoting* the binding of this [transcription factor] to DNA and increasing NF-kappaB dependent transcription . Positive_regulation TCF25 IL1B 16569740 1568490 OTR promoter contains putative [transcription factor] binding sites for activating protein-1 (AP-1) , CCAAT/enhancer binding protein (C/EBP) , and nuclear factor-kappaB (NF-kappaB) , which may be *activated* by , whose concentrations increase with labor . Positive_regulation TCF25 IL1B 16855208 1632223 The induced expression of human prostaglandin F2alpha receptor messenger RNA in human myometrial derived ULTR cells *requires* the [transcription factor] , NFkappaB . Positive_regulation TCF25 IL1B 18996492 2016036 Our results revealed that IL-1beta induced PBEF expression in pulmonary vascular endothelial cells at the transcriptional level and a -1535 T-variant in the human PBEF gene promoter significantly attenuated its binding to an *induced* unknown [transcription factor] . Positive_regulation TCF25 IL1B 8626526 360411 [Transcription factor] binding to the ATF/cAMP-responsive element consensus sequence was *increased* 4-5-fold by acetylsphingosine , PMA , or , whereas binding to the CCAAT/enhancer binding protein and AP-1 elements was found to be only slightly stimulated by these three agents . Positive_regulation TCF25 IL1B 8798568 381656 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by plus tumor necrosis factor-alpha , and its full induction *requires* the presence of the [transcription factor] , c-FOS . Positive_regulation TCF25 IL1B 9950608 589795 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to , tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Positive_regulation TCF25 ITGB2 15886116 1406833 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , *activation* of the NF-kappaB [transcription factor] , inside-out activation of the integrin , TCR clustering , and polarisation of the T cell . Positive_regulation TCF25 JAG1 16973960 1673638 and Delta-1 equally *activated* CBF-1/RBPJkappa [transcription factor] , which is a major Notch target . Positive_regulation TCF25 JAG1 17568183 1815734 [WNT-beta-catenin-TCF/LEF] signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , and DKK1 genes . Positive_regulation TCF25 NGFR 7536747 300286 In the case of purified Schwann cells , treatment with TGF-beta 1 increases their proliferation , and it promotes a pre- or nonmyelinating Schwann cell phenotype characterized by increased NCAM expression , decreased expression , inhibition of the forskolin mediated induction of the myelin protein P0 , and *induction* of the Schwann cell [transcription factor] suppressed cAMP-inducible POU protein . Positive_regulation TCF25 PTGER2 11706038 896757 We now report that the and EP(4) prostanoid receptors , which couple to Galpha ( s ) , also *activate* [Tcf/Lef] signaling . Positive_regulation TCF25 TCN1 18501609 1928135 Therefore , deficient may *lead* to abnormal expression of [TCF] . Positive_regulation TCF25 TLR7 19122179 2037199 signaling via p38 *led* to phosphorylation and activation of the transcription factor Microphthalmia [transcription factor] , acting at E-box elements in the Ctsk promoter . Positive_regulation TCF25 TNF 10075082 594848 Suppression of *activated* nuclear [transcription factor-kappaB] , activator protein-1 , c-Jun N-terminal kinase , and apoptosis by beta-lapachone . Positive_regulation TCF25 TNF 11093734 755020 Tumor necrosis factor alpha (TNF-alpha) binding to the initiates apoptosis and simultaneously *activates* the [transcription factor] , nuclear factor-kappaB (NF-kappaB) , which suppresses apoptosis by an unknown mechanism . Positive_regulation TCF25 TNF 11572998 864825 This study examines the effect of a triterpene mixture ( F094 ) and a single molecular species ( avicin G ) isolated from the mixture on *induced* activation of nuclear [transcription factor-kappaB] ( NF-kappaB ) in Jurkat cells ( human T cell leukemia ) . Positive_regulation TCF25 TNF 12091427 960144 Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB , whereas potently *induced* this [transcription factor] . Positive_regulation TCF25 TNF 12604246 1062602 Stimulation of the VECs with *led* to an increase in the DNA binding activity of the [transcription factor] , nuclear factor-kappa binding protein ( NF-kappaB ) and the induction of the adhesion molecule ( ICAM)-1 . Positive_regulation TCF25 TNF 12633744 1068277 Furthermore , treatment of HAEC with 0.5 mM DFO or NC completely inhibited induced *activation* of the [transcription factor] , specificity protein-1 (SP-1) , but only partially inhibited or did not affect activation of other transcription factors known to regulate adhesion molecule expression , i.e. , nuclear factor kappaB (NFkappaB) , activator protein-1 (AP-1) , and interferon regulatory factor-1 (IRF-1) . Positive_regulation TCF25 TNF 12810554 1102604 also *impairs* the ability of IGF-I to induce expression of a key myogenic [transcription factor] , myogenin . Positive_regulation TCF25 TNF 12890427 1117259 At the molecular level , EXPLY-37 did not inhibit the *activation* of the nuclear factor kappa B (NF-kappaB) [transcription factor] by . Positive_regulation TCF25 TNF 12893683 1135169 Ginkgo biloba extract inhibits induced reactive oxygen species generation , [transcription factor] *activation* , and cell adhesion molecule expression in human aortic endothelial cells . Positive_regulation TCF25 TNF 14646597 1173196 *induced* activation of both c-jun NH ( 2 ) -terminal kinase ( JNK ) and nuclear [transcription factor-kappaB] ( NF-kappaB ) in 3T3-L1 cells . Positive_regulation TCF25 TNF 15374848 1323855 Carvedilol inhibits *induced* endothelial [transcription factor] activation , adhesion molecule expression , and adhesiveness to human mononuclear cells . Positive_regulation TCF25 TNF 15593122 1361705 In the colons , a *inducing* [transcription factor] , LPS induced TNF-alpha factor (LITAF) , was inhibited by 1,25D3 , but not by calcium . Positive_regulation TCF25 TNF 15753227 1380087 and glucose *induced* a dose- and time dependent activation of the p38 MAP kinase , the downstream kinase mitogen- and stress activated kinase 1 , and the [transcription factor] cAMP-responsive element binding protein ( CREB ) , in EPCs . Positive_regulation TCF25 TNF 16006484 1459265 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the [transcription factor] ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TCF25 TNF 16046706 1438321 Palmitate activates the NF-kappaB [transcription factor] and *induces* IL-6 and expression in 3T3-L1 adipocytes . Positive_regulation TCF25 TNF 16338458 1503940 EMSA indicated *induced* binding of the inflammatory [transcription factor] to an NFkappaB consensus sequence and to the NFkappaB recognition site located in the PAI-1 promoter . Positive_regulation TCF25 TNF 16978650 1633546 Peptide YY reverses *induced* [transcription factor] binding of interferon regulatory factor-1 and p53 in pancreatic acinar cells . Positive_regulation TCF25 TNF 17035338 1674547 Taken together , our data suggest that the produced in response to IFN-gamma is *required* for iNOS induction by activating NF-kappaB [transcription factor] . Positive_regulation TCF25 TNF 17210691 1681516 The survival mechanism requires nuclear factor-kappaB (NF-kappaB) [transcription factor] activity , which is strongly *induced* by in these cells . Positive_regulation TCF25 TNF 17449583 1730009 Quercetin inhibits *induced* NF-kappaB [transcription factor] recruitment to proinflammatory gene promoters in murine intestinal epithelial cells . Positive_regulation TCF25 TNF 18094051 1869018 We find that NGF can *induce* synthesis through the nuclear factor-kappaB [transcription factor] . Positive_regulation TCF25 TNF 19138739 2037797 We examined whether or not 1alpha,25- ( OH ) ( 2 ) D ( 3 ) inhibits the induced *activation* of nuclear [transcription factor-kappaB] ( NF-kappaB ) , which is essential for the expression of proinflammatory cytokines in HCAEC , by ELISA . Positive_regulation TCF25 TNF 20133051 2242222 In the search of the molecular mechanisms responsible for the sensitization effect of chrysin , we discovered that such sensitization is closely associated with the inhibitory effect of chrysin on *mediated* nuclear [transcription factor-kappaB] ( NF-kappaB ) activation . Positive_regulation TCF25 TNF 20617556 2286552 Overexpression of the p65/RelA subunit of NF-kappaB , a *activated* inflammatory [transcription factor] , in A7r5 cells , upregulated SIRT1 mRNA and protein expression as well as SIRT1 promoter activity , while knockdown of endogenous p65/RelA expression by RNAi not only led to a decrease in SIRT1 's basal protein expression and promoter activity , but almost abolished the TNF-alpha induced elevation of SIRT1 protein expression and SIRT1 promoter activity . Positive_regulation TCF25 TNF 2104232 150544 *induces* binding of the NF-kappa B [transcription factor] to a high-affinity kappa B element in the TNF-beta promoter . Positive_regulation TCF25 TNF 21389273 2443520 Functionally , TNF-a stimulated H ( 2 ) O ( 2 ) production was also blocked by MCD and DES ( 194.6 ± 15.4 % vs. 90.6 ± 15.9 % and 148.8 ± 20.4 % ) , and the *activation* of the pivotal proinflammatory [transcription factor] , NF-?B , by was reversed by MCD and DES as well as by small interfering RNAs of Duox1 or ASMase . Positive_regulation TCF25 TNF 21541574 407733 These results are in contrast to those reported for the murine p53 gene , whose promoter is *induced* by through activation of the NF-kappa B [transcription factor] . Positive_regulation TCF25 TNF 8798568 381655 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by interleukin-1beta plus , and its full induction *requires* the presence of the [transcription factor] , c-FOS . Positive_regulation TCF25 TNF 9582369 504189 Overexpression of manganese superoxide dismutase suppresses *induced* apoptosis and activation of nuclear [transcription factor-kappaB] and activated protein-1 . Positive_regulation TCF25 TNF 9794740 543107 To determine whether the [transcription factor] nuclear factor-kappaB mediated expression of these genes involved in the inflammatory *response* of endothelial cells to , by using transcription factor decoy oligodeoxynucleotides . Positive_regulation TCF25 TNF 9950608 589793 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to interleukin-1beta (IL-1beta) , , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Positive_regulation TCF25 TP63 21741828 2599108 In this study we show that *induces* the expression of the basal epithelial [transcription factor] , Basonuclin 1 . Positive_regulation TCF25 WNT7A 11782388 900404 Coculture experiments demonstrated that Wnt-1 , but not Wnt-5A and , *activated* the [TCF] reporter gene . Positive_regulation TCF25 WNT7A 17431004 1748949 *stimulated* a [TCF/LEF-luciferase] reporter activity in ovine trophectoderm cells that was inhibited by dominant negative TCF and Sfrp2 ( secreted FZD related protein 2 ) . Positive_regulation TCF25 ZFP57 19234145 2072269 The other was the 5 ' noncoding region of a [transcription factor] , Zfp423 , which *induced* aberrant expression . Positive_regulation TCF3 ADRB2 15024018 1243846 To identify the mechanism responsible for this effect , we determined whether CD86 and/or stimulation *regulated* [transcription factor] expression and binding to the 3'-IgH enhancer in vitro and in vivo . Positive_regulation TCF3 AXIN2 11809808 906684 [Wnt/beta-catenin/Tcf] signaling *induces* the transcription of , a negative regulator of the signaling pathway . Positive_regulation TCF3 CCND1 14706452 1196353 The strong binding of E2F1 and NFkappaB is especially noteworthy , because the former [transcription factor] is *regulated* by , a downstream target of beta-catenin/TCF/LEF signaling , whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways . Positive_regulation TCF3 CCND1 15893541 1407592 The increased protein level was *induced* through activation of the [transcription factor] , nuclear factor kB ( NFkappaB ) , in the NHBE cells . Positive_regulation TCF3 CCND1 23135283 2707310 We find that knockdown of PAX2 inhibits the activity of AP-1 , a [transcription factor] that *induces* expression , implying that PAX2 induces cyclin D1 through AP-1 . Positive_regulation TCF3 CCND1 24979278 2947644 Thus , full activation of promoter activity *requires* ß-catenin activation of [TCF-lef] and stabilization of specific p120 catenin isoforms to relieve the repression of KAISO . Positive_regulation TCF3 CCND1 7970707 280069 *Activation* of the E2F [transcription factor] by is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation TCF3 CTGF 15601748 1361751 K252a , a known selective inhibitor of Trk , blocked this phosphorylation , induced *activation* of signaling proteins , and CTGF dependent induction of the [transcription factor] TGF-beta-inducible early gene in HMC . Positive_regulation TCF3 EPHB2 11784711 922013 Superoxide mediates shock wave induction of *dependent* osteogenic [transcription factor] ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors . Positive_regulation TCF3 EPHB2 11880483 919401 BDNF-LTP was further coupled to *dependent* phosphorylation of the [transcription factor] cAMP response element binding protein . Positive_regulation TCF3 EPHB2 15089040 1237820 Several reports indicate that the activation of extracellular signal regulated kinase ( ) *induces* microphthalmia associated [transcription factor] ( MITF ) degradation . Positive_regulation TCF3 EPHB2 15253728 1271685 *induces* increases in activator protein-1 (AP-1) [transcription factor] activity which may augment mesangial cell proliferation and ECM protein production . Positive_regulation TCF3 EPHB2 17117479 1677439 Finally , we show that activated *induced* increased expression of the Egr-1 [transcription factor] , which then bound to the promoter region of p35 . Positive_regulation TCF3 EPHB2 19910471 2189316 Active *increases* expression and activity of the c-Jun [transcription factor] , linking ERK and Jun N-terminal kinase (JNK) cascades . Positive_regulation TCF3 EPHB2 21144616 2419307 Receptors that belong to the family of death-receptors including TNF receptor-1 (TNF-R1) , CD95 ( Fas , APO-1 ) and TRAIL receptors ( TRAIL-R1 , TRAIL R2/DR4/DR5 ) transduce signals resulting in entirely different biological outcomes : They promote cell death via apoptosis but are also capable of inducing anti-apoptotic signals through the [transcription factor] nuclear factor NF-?B or *activation* of the proliferative protein kinase cascade resulting in cell protection and tissue regeneration . Positive_regulation TCF3 EPHB2 21890597 2506385 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and dependent *activation* of the CCAAT/enhancer binding protein beta [transcription factor] independent of p53 . Positive_regulation TCF3 EPHB2 24085800 2902614 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of and *activation* of Ets-1 [transcription factor] . Positive_regulation TCF3 EPHB2 8657129 364842 Analysis of the *stimulated* ETS [transcription factor] ER81 . Positive_regulation TCF3 FBXO32 18367868 1898774 FoxO3 [transcription factor] causes marked atrophy in adult skeletal muscle and *induces* the muscle-specific ubiquitin ligase ( 1 ) In addition , we recently reported that FoxO3 is necessary and sufficient for the induction of autophagy in skeletal muscle . Positive_regulation TCF3 HBEGF 23909989 2861566 Heparin-binding-epidermal growth factor ( ) down-regulates Claudin-3 expression , but *enhances* [transcription factor] Snail expression . Positive_regulation TCF3 IL1B 10816656 580256 Since the molecular basis of these antiinflammatory effects is not well known , the influence of alpha-MSH on induced chemokine production and [transcription factor] *activation* was investigated in human keratinocytes . Positive_regulation TCF3 IL1B 15217752 1263819 However , the contribution by p38 to the induction of inducible nitric oxide synthase (iNOS) and apoptosis is independent of NF-kappaB nuclear translocation since SB203580 does not prevent *induced* DNA binding of this [transcription factor] . Positive_regulation TCF3 IL1B 16326073 1553772 induced NF-kappaB activation in Caco-2 cells , *promoting* the binding of this [transcription factor] to DNA and increasing NF-kappaB dependent transcription . Positive_regulation TCF3 IL1B 16569740 1568486 OTR promoter contains putative [transcription factor] binding sites for activating protein-1 (AP-1) , CCAAT/enhancer binding protein (C/EBP) , and nuclear factor-kappaB (NF-kappaB) , which may be *activated* by , whose concentrations increase with labor . Positive_regulation TCF3 IL1B 16855208 1632219 The induced expression of human prostaglandin F2alpha receptor messenger RNA in human myometrial derived ULTR cells *requires* the [transcription factor] , NFkappaB . Positive_regulation TCF3 IL1B 18996492 2016032 Our results revealed that IL-1beta induced PBEF expression in pulmonary vascular endothelial cells at the transcriptional level and a -1535 T-variant in the human PBEF gene promoter significantly attenuated its binding to an *induced* unknown [transcription factor] . Positive_regulation TCF3 IL1B 8626526 360407 [Transcription factor] binding to the ATF/cAMP-responsive element consensus sequence was *increased* 4-5-fold by acetylsphingosine , PMA , or , whereas binding to the CCAAT/enhancer binding protein and AP-1 elements was found to be only slightly stimulated by these three agents . Positive_regulation TCF3 IL1B 8798568 381637 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by plus tumor necrosis factor-alpha , and its full induction *requires* the presence of the [transcription factor] , c-FOS . Positive_regulation TCF3 IL1B 9950608 589783 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to , tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Positive_regulation TCF3 ITGB2 15886116 1406825 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , *activation* of the NF-kappaB [transcription factor] , inside-out activation of the integrin , TCR clustering , and polarisation of the T cell . Positive_regulation TCF3 JAG1 16973960 1673630 and Delta-1 equally *activated* CBF-1/RBPJkappa [transcription factor] , which is a major Notch target . Positive_regulation TCF3 JAG1 17568183 1815679 [WNT-beta-catenin-TCF/LEF] signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , and DKK1 genes . Positive_regulation TCF3 NGFR 7536747 300278 In the case of purified Schwann cells , treatment with TGF-beta 1 increases their proliferation , and it promotes a pre- or nonmyelinating Schwann cell phenotype characterized by increased NCAM expression , decreased expression , inhibition of the forskolin mediated induction of the myelin protein P0 , and *induction* of the Schwann cell [transcription factor] suppressed cAMP-inducible POU protein . Positive_regulation TCF3 PTGER2 11706038 896749 We now report that the and EP(4) prostanoid receptors , which couple to Galpha ( s ) , also *activate* [Tcf/Lef] signaling . Positive_regulation TCF3 TCN1 18501609 1928131 Therefore , deficient may *lead* to abnormal expression of [TCF] . Positive_regulation TCF3 TLR7 19122179 2037159 signaling via p38 *led* to phosphorylation and activation of the transcription factor Microphthalmia [transcription factor] , acting at E-box elements in the Ctsk promoter . Positive_regulation TCF3 TNF 10075082 594844 Suppression of *activated* nuclear [transcription factor-kappaB] , activator protein-1 , c-Jun N-terminal kinase , and apoptosis by beta-lapachone . Positive_regulation TCF3 TNF 11093734 755016 Tumor necrosis factor alpha (TNF-alpha) binding to the initiates apoptosis and simultaneously *activates* the [transcription factor] , nuclear factor-kappaB (NF-kappaB) , which suppresses apoptosis by an unknown mechanism . Positive_regulation TCF3 TNF 11572998 864821 This study examines the effect of a triterpene mixture ( F094 ) and a single molecular species ( avicin G ) isolated from the mixture on *induced* activation of nuclear [transcription factor-kappaB] ( NF-kappaB ) in Jurkat cells ( human T cell leukemia ) . Positive_regulation TCF3 TNF 12091427 960129 Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB , whereas potently *induced* this [transcription factor] . Positive_regulation TCF3 TNF 12604246 1062598 Stimulation of the VECs with *led* to an increase in the DNA binding activity of the [transcription factor] , nuclear factor-kappa binding protein ( NF-kappaB ) and the induction of the adhesion molecule ( ICAM)-1 . Positive_regulation TCF3 TNF 12633744 1068273 Furthermore , treatment of HAEC with 0.5 mM DFO or NC completely inhibited induced *activation* of the [transcription factor] , specificity protein-1 (SP-1) , but only partially inhibited or did not affect activation of other transcription factors known to regulate adhesion molecule expression , i.e. , nuclear factor kappaB (NFkappaB) , activator protein-1 (AP-1) , and interferon regulatory factor-1 (IRF-1) . Positive_regulation TCF3 TNF 12810554 1102596 also *impairs* the ability of IGF-I to induce expression of a key myogenic [transcription factor] , myogenin . Positive_regulation TCF3 TNF 12890427 1117244 At the molecular level , EXPLY-37 did not inhibit the *activation* of the nuclear factor kappa B (NF-kappaB) [transcription factor] by . Positive_regulation TCF3 TNF 12893683 1135164 Ginkgo biloba extract inhibits *induced* reactive oxygen species generation , [transcription factor] activation , and cell adhesion molecule expression in human aortic endothelial cells . Positive_regulation TCF3 TNF 14646597 1173181 *induced* activation of both c-jun NH ( 2 ) -terminal kinase ( JNK ) and nuclear [transcription factor-kappaB] ( NF-kappaB ) in 3T3-L1 cells . Positive_regulation TCF3 TNF 15374848 1323851 Carvedilol inhibits induced endothelial [transcription factor] *activation* , adhesion molecule expression , and adhesiveness to human mononuclear cells . Positive_regulation TCF3 TNF 15593122 1361700 In the colons , a *inducing* [transcription factor] , LPS induced TNF-alpha factor (LITAF) , was inhibited by 1,25D3 , but not by calcium . Positive_regulation TCF3 TNF 15753227 1380080 and glucose *induced* a dose- and time dependent activation of the p38 MAP kinase , the downstream kinase mitogen- and stress activated kinase 1 , and the [transcription factor] cAMP-responsive element binding protein ( CREB ) , in EPCs . Positive_regulation TCF3 TNF 16006484 1459244 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the [transcription factor] ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TCF3 TNF 16046706 1438302 Palmitate activates the NF-kappaB [transcription factor] and *induces* IL-6 and expression in 3T3-L1 adipocytes . Positive_regulation TCF3 TNF 16338458 1503936 EMSA indicated *induced* binding of the inflammatory [transcription factor] to an NFkappaB consensus sequence and to the NFkappaB recognition site located in the PAI-1 promoter . Positive_regulation TCF3 TNF 16978650 1633541 Peptide YY reverses *induced* [transcription factor] binding of interferon regulatory factor-1 and p53 in pancreatic acinar cells . Positive_regulation TCF3 TNF 17035338 1674531 Taken together , our data suggest that the produced in response to IFN-gamma is *required* for iNOS induction by activating NF-kappaB [transcription factor] . Positive_regulation TCF3 TNF 17210691 1681512 The survival mechanism requires nuclear factor-kappaB (NF-kappaB) [transcription factor] activity , which is strongly *induced* by in these cells . Positive_regulation TCF3 TNF 17449583 1730005 Quercetin inhibits *induced* NF-kappaB [transcription factor] recruitment to proinflammatory gene promoters in murine intestinal epithelial cells . Positive_regulation TCF3 TNF 18094051 1869009 We find that NGF can *induce* synthesis through the nuclear factor-kappaB [transcription factor] . Positive_regulation TCF3 TNF 19138739 2037793 We examined whether or not 1alpha,25- ( OH ) ( 2 ) D ( 3 ) inhibits the induced *activation* of nuclear [transcription factor-kappaB] ( NF-kappaB ) , which is essential for the expression of proinflammatory cytokines in HCAEC , by ELISA . Positive_regulation TCF3 TNF 20133051 2242218 In the search of the molecular mechanisms responsible for the sensitization effect of chrysin , we discovered that such sensitization is closely associated with the inhibitory effect of chrysin on *mediated* nuclear [transcription factor-kappaB] ( NF-kappaB ) activation . Positive_regulation TCF3 TNF 20617556 2286548 Overexpression of the p65/RelA subunit of NF-kappaB , a *activated* inflammatory [transcription factor] , in A7r5 cells , upregulated SIRT1 mRNA and protein expression as well as SIRT1 promoter activity , while knockdown of endogenous p65/RelA expression by RNAi not only led to a decrease in SIRT1 's basal protein expression and promoter activity , but almost abolished the TNF-alpha induced elevation of SIRT1 protein expression and SIRT1 promoter activity . Positive_regulation TCF3 TNF 2104232 150540 *induces* binding of the NF-kappa B [transcription factor] to a high-affinity kappa B element in the TNF-beta promoter . Positive_regulation TCF3 TNF 21389273 2443505 Functionally , TNF-a stimulated H ( 2 ) O ( 2 ) production was also blocked by MCD and DES ( 194.6 ± 15.4 % vs. 90.6 ± 15.9 % and 148.8 ± 20.4 % ) , and the *activation* of the pivotal proinflammatory [transcription factor] , NF-?B , by was reversed by MCD and DES as well as by small interfering RNAs of Duox1 or ASMase . Positive_regulation TCF3 TNF 21541574 407729 These results are in contrast to those reported for the murine p53 gene , whose promoter is *induced* by through activation of the NF-kappa B [transcription factor] . Positive_regulation TCF3 TNF 8798568 381636 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by interleukin-1beta plus , and its full induction *requires* the presence of the [transcription factor] , c-FOS . Positive_regulation TCF3 TNF 9582369 504185 Overexpression of manganese superoxide dismutase suppresses *induced* apoptosis and activation of nuclear [transcription factor-kappaB] and activated protein-1 . Positive_regulation TCF3 TNF 9794740 543103 To determine whether the [transcription factor] nuclear factor-kappaB mediated expression of these genes involved in the inflammatory *response* of endothelial cells to , by using transcription factor decoy oligodeoxynucleotides . Positive_regulation TCF3 TNF 9950608 589781 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to interleukin-1beta (IL-1beta) , , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Positive_regulation TCF3 TP63 21741828 2599104 In this study we show that *induces* the expression of the basal epithelial [transcription factor] , Basonuclin 1 . Positive_regulation TCF3 WNT7A 11782388 900392 Coculture experiments demonstrated that Wnt-1 , but not Wnt-5A and , *activated* the [TCF] reporter gene . Positive_regulation TCF3 WNT7A 17431004 1748945 *stimulated* a [TCF/LEF-luciferase] reporter activity in ovine trophectoderm cells that was inhibited by dominant negative TCF and Sfrp2 ( secreted FZD related protein 2 ) . Positive_regulation TCF3 ZFP57 19234145 2072197 The other was the 5 ' noncoding region of a [transcription factor] , Zfp423 , which *induced* aberrant expression . Positive_regulation TCF4 ADRB2 15024018 1243848 To identify the mechanism responsible for this effect , we determined whether CD86 and/or stimulation *regulated* [transcription factor] expression and binding to the 3'-IgH enhancer in vitro and in vivo . Positive_regulation TCF4 AXIN2 11809808 906685 [Wnt/beta-catenin/Tcf] signaling *induces* the transcription of , a negative regulator of the signaling pathway . Positive_regulation TCF4 CCND1 14706452 1196354 The strong binding of E2F1 and NFkappaB is especially noteworthy , because the former [transcription factor] is *regulated* by , a downstream target of beta-catenin/TCF/LEF signaling , whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways . Positive_regulation TCF4 CCND1 15893541 1407593 The increased protein level was *induced* through activation of the [transcription factor] , nuclear factor kB ( NFkappaB ) , in the NHBE cells . Positive_regulation TCF4 CCND1 23135283 2707311 We find that knockdown of PAX2 inhibits the activity of AP-1 , a [transcription factor] that *induces* expression , implying that PAX2 induces cyclin D1 through AP-1 . Positive_regulation TCF4 CCND1 24979278 2947645 Thus , full activation of promoter activity *requires* ß-catenin activation of [TCF-lef] and stabilization of specific p120 catenin isoforms to relieve the repression of KAISO . Positive_regulation TCF4 CCND1 7970707 280071 *Activation* of the E2F [transcription factor] by is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation TCF4 CTGF 15601748 1361752 K252a , a known selective inhibitor of Trk , blocked this phosphorylation , CTGF induced activation of signaling proteins , and dependent *induction* of the [transcription factor] TGF-beta-inducible early gene in HMC . Positive_regulation TCF4 EPHB2 11784711 922014 Superoxide mediates shock wave induction of *dependent* osteogenic [transcription factor] ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors . Positive_regulation TCF4 EPHB2 11880483 919402 BDNF-LTP was further coupled to *dependent* phosphorylation of the [transcription factor] cAMP response element binding protein . Positive_regulation TCF4 EPHB2 15089040 1237821 Several reports indicate that the activation of extracellular signal regulated kinase ( ) *induces* microphthalmia associated [transcription factor] ( MITF ) degradation . Positive_regulation TCF4 EPHB2 15253728 1271686 *induces* increases in activator protein-1 (AP-1) [transcription factor] activity which may augment mesangial cell proliferation and ECM protein production . Positive_regulation TCF4 EPHB2 17117479 1677440 Finally , we show that activated *induced* increased expression of the Egr-1 [transcription factor] , which then bound to the promoter region of p35 . Positive_regulation TCF4 EPHB2 19910471 2189317 Active *increases* expression and activity of the c-Jun [transcription factor] , linking ERK and Jun N-terminal kinase (JNK) cascades . Positive_regulation TCF4 EPHB2 21144616 2419321 Receptors that belong to the family of death-receptors including TNF receptor-1 (TNF-R1) , CD95 ( Fas , APO-1 ) and TRAIL receptors ( TRAIL-R1 , TRAIL R2/DR4/DR5 ) transduce signals resulting in entirely different biological outcomes : They promote cell death via apoptosis but are also capable of inducing anti-apoptotic signals through the [transcription factor] nuclear factor NF-?B or *activation* of the proliferative protein kinase cascade resulting in cell protection and tissue regeneration . Positive_regulation TCF4 EPHB2 21890597 2506386 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and *dependent* activation of the CCAAT/enhancer binding protein beta [transcription factor] independent of p53 . Positive_regulation TCF4 EPHB2 24085800 2902615 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of and *activation* of Ets-1 [transcription factor] . Positive_regulation TCF4 EPHB2 8657129 364843 Analysis of the *stimulated* ETS [transcription factor] ER81 . Positive_regulation TCF4 FBXO32 18367868 1898775 FoxO3 [transcription factor] causes marked atrophy in adult skeletal muscle and *induces* the muscle-specific ubiquitin ligase ( 1 ) In addition , we recently reported that FoxO3 is necessary and sufficient for the induction of autophagy in skeletal muscle . Positive_regulation TCF4 HBEGF 23909989 2861568 Heparin-binding-epidermal growth factor ( ) down-regulates Claudin-3 expression , but *enhances* [transcription factor] Snail expression . Positive_regulation TCF4 IL1B 10816656 580257 Since the molecular basis of these antiinflammatory effects is not well known , the influence of alpha-MSH on *induced* chemokine production and [transcription factor] activation was investigated in human keratinocytes . Positive_regulation TCF4 IL1B 15217752 1263820 However , the contribution by p38 to the induction of inducible nitric oxide synthase (iNOS) and apoptosis is independent of NF-kappaB nuclear translocation since SB203580 does not prevent *induced* DNA binding of this [transcription factor] . Positive_regulation TCF4 IL1B 16326073 1553775 induced NF-kappaB activation in Caco-2 cells , *promoting* the binding of this [transcription factor] to DNA and increasing NF-kappaB dependent transcription . Positive_regulation TCF4 IL1B 16569740 1568487 OTR promoter contains putative [transcription factor] binding sites for activating protein-1 (AP-1) , CCAAT/enhancer binding protein (C/EBP) , and nuclear factor-kappaB (NF-kappaB) , which may be *activated* by , whose concentrations increase with labor . Positive_regulation TCF4 IL1B 16855208 1632220 The induced expression of human prostaglandin F2alpha receptor messenger RNA in human myometrial derived ULTR cells *requires* the [transcription factor] , NFkappaB . Positive_regulation TCF4 IL1B 18996492 2016033 Our results revealed that IL-1beta induced PBEF expression in pulmonary vascular endothelial cells at the transcriptional level and a -1535 T-variant in the human PBEF gene promoter significantly attenuated its binding to an *induced* unknown [transcription factor] . Positive_regulation TCF4 IL1B 8626526 360408 [Transcription factor] binding to the ATF/cAMP-responsive element consensus sequence was *increased* 4-5-fold by acetylsphingosine , PMA , or , whereas binding to the CCAAT/enhancer binding protein and AP-1 elements was found to be only slightly stimulated by these three agents . Positive_regulation TCF4 IL1B 8798568 381639 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by plus tumor necrosis factor-alpha , and its full induction *requires* the presence of the [transcription factor] , c-FOS . Positive_regulation TCF4 IL1B 9950608 589786 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to , tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Positive_regulation TCF4 ITGB2 15886116 1406827 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , *activation* of the NF-kappaB [transcription factor] , inside-out activation of the integrin , TCR clustering , and polarisation of the T cell . Positive_regulation TCF4 JAG1 16973960 1673632 and Delta-1 equally *activated* CBF-1/RBPJkappa [transcription factor] , which is a major Notch target . Positive_regulation TCF4 JAG1 17568183 1815682 [WNT-beta-catenin-TCF/LEF] signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , and DKK1 genes . Positive_regulation TCF4 NGFR 7536747 300280 In the case of purified Schwann cells , treatment with TGF-beta 1 increases their proliferation , and it promotes a pre- or nonmyelinating Schwann cell phenotype characterized by increased NCAM expression , decreased expression , inhibition of the forskolin mediated induction of the myelin protein P0 , and *induction* of the Schwann cell [transcription factor] suppressed cAMP-inducible POU protein . Positive_regulation TCF4 PTGER2 11706038 896751 We now report that the and EP(4) prostanoid receptors , which couple to Galpha ( s ) , also *activate* [Tcf/Lef] signaling . Positive_regulation TCF4 TCN1 18501609 1928132 Therefore , deficient may *lead* to abnormal expression of [TCF] . Positive_regulation TCF4 TLR7 19122179 2037169 signaling via p38 *led* to phosphorylation and activation of the transcription factor Microphthalmia [transcription factor] , acting at E-box elements in the Ctsk promoter . Positive_regulation TCF4 TNF 10075082 594845 Suppression of *activated* nuclear [transcription factor-kappaB] , activator protein-1 , c-Jun N-terminal kinase , and apoptosis by beta-lapachone . Positive_regulation TCF4 TNF 11093734 755017 binding to the TNF receptor (TNFR) initiates apoptosis and simultaneously *activates* the [transcription factor] , nuclear factor-kappaB (NF-kappaB) , which suppresses apoptosis by an unknown mechanism . Positive_regulation TCF4 TNF 11572998 864822 This study examines the effect of a triterpene mixture ( F094 ) and a single molecular species ( avicin G ) isolated from the mixture on induced *activation* of nuclear [transcription factor-kappaB] ( NF-kappaB ) in Jurkat cells ( human T cell leukemia ) . Positive_regulation TCF4 TNF 12091427 960130 Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB , whereas potently *induced* this [transcription factor] . Positive_regulation TCF4 TNF 12604246 1062599 Stimulation of the VECs with *led* to an increase in the DNA binding activity of the [transcription factor] , nuclear factor-kappa binding protein ( NF-kappaB ) and the induction of the adhesion molecule ( ICAM)-1 . Positive_regulation TCF4 TNF 12633744 1068274 Furthermore , treatment of HAEC with 0.5 mM DFO or NC completely inhibited induced *activation* of the [transcription factor] , specificity protein-1 (SP-1) , but only partially inhibited or did not affect activation of other transcription factors known to regulate adhesion molecule expression , i.e. , nuclear factor kappaB (NFkappaB) , activator protein-1 (AP-1) , and interferon regulatory factor-1 (IRF-1) . Positive_regulation TCF4 TNF 12810554 1102598 also *impairs* the ability of IGF-I to induce expression of a key myogenic [transcription factor] , myogenin . Positive_regulation TCF4 TNF 12890427 1117245 At the molecular level , EXPLY-37 did not inhibit the *activation* of the nuclear factor kappa B (NF-kappaB) [transcription factor] by . Positive_regulation TCF4 TNF 12893683 1135165 Ginkgo biloba extract inhibits induced reactive oxygen species generation , [transcription factor] *activation* , and cell adhesion molecule expression in human aortic endothelial cells . Positive_regulation TCF4 TNF 14646597 1173182 *induced* activation of both c-jun NH ( 2 ) -terminal kinase ( JNK ) and nuclear [transcription factor-kappaB] ( NF-kappaB ) in 3T3-L1 cells . Positive_regulation TCF4 TNF 15374848 1323852 Carvedilol inhibits induced endothelial [transcription factor] *activation* , adhesion molecule expression , and adhesiveness to human mononuclear cells . Positive_regulation TCF4 TNF 15593122 1361701 In the colons , a *inducing* [transcription factor] , LPS induced TNF-alpha factor (LITAF) , was inhibited by 1,25D3 , but not by calcium . Positive_regulation TCF4 TNF 15753227 1380081 and glucose *induced* a dose- and time dependent activation of the p38 MAP kinase , the downstream kinase mitogen- and stress activated kinase 1 , and the [transcription factor] cAMP-responsive element binding protein ( CREB ) , in EPCs . Positive_regulation TCF4 TNF 16006484 1459246 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the [transcription factor] ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TCF4 TNF 16046706 1438304 Palmitate activates the NF-kappaB [transcription factor] and *induces* IL-6 and expression in 3T3-L1 adipocytes . Positive_regulation TCF4 TNF 16338458 1503937 EMSA indicated *induced* binding of the inflammatory [transcription factor] to an NFkappaB consensus sequence and to the NFkappaB recognition site located in the PAI-1 promoter . Positive_regulation TCF4 TNF 16978650 1633542 Peptide YY reverses *induced* [transcription factor] binding of interferon regulatory factor-1 and p53 in pancreatic acinar cells . Positive_regulation TCF4 TNF 17035338 1674532 Taken together , our data suggest that the produced in response to IFN-gamma is *required* for iNOS induction by activating NF-kappaB [transcription factor] . Positive_regulation TCF4 TNF 17210691 1681513 The survival mechanism requires nuclear factor-kappaB (NF-kappaB) [transcription factor] activity , which is strongly *induced* by in these cells . Positive_regulation TCF4 TNF 17449583 1730006 Quercetin inhibits *induced* NF-kappaB [transcription factor] recruitment to proinflammatory gene promoters in murine intestinal epithelial cells . Positive_regulation TCF4 TNF 18094051 1869011 We find that NGF can *induce* synthesis through the nuclear factor-kappaB [transcription factor] . Positive_regulation TCF4 TNF 19138739 2037794 We examined whether or not 1alpha,25- ( OH ) ( 2 ) D ( 3 ) inhibits the *induced* activation of nuclear [transcription factor-kappaB] ( NF-kappaB ) , which is essential for the expression of proinflammatory cytokines in HCAEC , by ELISA . Positive_regulation TCF4 TNF 20133051 2242219 In the search of the molecular mechanisms responsible for the sensitization effect of chrysin , we discovered that such sensitization is closely associated with the inhibitory effect of chrysin on *mediated* nuclear [transcription factor-kappaB] ( NF-kappaB ) activation . Positive_regulation TCF4 TNF 20617556 2286549 Overexpression of the p65/RelA subunit of NF-kappaB , a *activated* inflammatory [transcription factor] , in A7r5 cells , upregulated SIRT1 mRNA and protein expression as well as SIRT1 promoter activity , while knockdown of endogenous p65/RelA expression by RNAi not only led to a decrease in SIRT1 's basal protein expression and promoter activity , but almost abolished the TNF-alpha induced elevation of SIRT1 protein expression and SIRT1 promoter activity . Positive_regulation TCF4 TNF 2104232 150541 *induces* binding of the NF-kappa B [transcription factor] to a high-affinity kappa B element in the TNF-beta promoter . Positive_regulation TCF4 TNF 21389273 2443506 Functionally , TNF-a stimulated H ( 2 ) O ( 2 ) production was also blocked by MCD and DES ( 194.6 ± 15.4 % vs. 90.6 ± 15.9 % and 148.8 ± 20.4 % ) , and the *activation* of the pivotal proinflammatory [transcription factor] , NF-?B , by was reversed by MCD and DES as well as by small interfering RNAs of Duox1 or ASMase . Positive_regulation TCF4 TNF 21541574 407730 These results are in contrast to those reported for the murine p53 gene , whose promoter is *induced* by through activation of the NF-kappa B [transcription factor] . Positive_regulation TCF4 TNF 8798568 381638 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by interleukin-1beta plus , and its full induction *requires* the presence of the [transcription factor] , c-FOS . Positive_regulation TCF4 TNF 9582369 504186 Overexpression of manganese superoxide dismutase suppresses *induced* apoptosis and activation of nuclear [transcription factor-kappaB] and activated protein-1 . Positive_regulation TCF4 TNF 9794740 543104 To determine whether the [transcription factor] nuclear factor-kappaB mediated expression of these genes involved in the inflammatory *response* of endothelial cells to , by using transcription factor decoy oligodeoxynucleotides . Positive_regulation TCF4 TNF 9950608 589784 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to interleukin-1beta (IL-1beta) , , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Positive_regulation TCF4 TP63 21741828 2599105 In this study we show that *induces* the expression of the basal epithelial [transcription factor] , Basonuclin 1 . Positive_regulation TCF4 WNT7A 11782388 900395 Coculture experiments demonstrated that Wnt-1 , but not Wnt-5A and , *activated* the [TCF] reporter gene . Positive_regulation TCF4 WNT7A 17431004 1748946 *stimulated* a [TCF/LEF-luciferase] reporter activity in ovine trophectoderm cells that was inhibited by dominant negative TCF and Sfrp2 ( secreted FZD related protein 2 ) . Positive_regulation TCF4 ZFP57 19234145 2072215 The other was the 5 ' noncoding region of a [transcription factor] , Zfp423 , which *induced* aberrant expression . Positive_regulation TCF7 ADRB2 15024018 1243850 To identify the mechanism responsible for this effect , we determined whether CD86 and/or stimulation *regulated* [transcription factor] expression and binding to the 3'-IgH enhancer in vitro and in vivo . Positive_regulation TCF7 AXIN2 11809808 906686 [Wnt/beta-catenin/Tcf] signaling *induces* the transcription of , a negative regulator of the signaling pathway . Positive_regulation TCF7 CCND1 14706452 1196355 The strong binding of E2F1 and NFkappaB is especially noteworthy , because the former [transcription factor] is *regulated* by , a downstream target of beta-catenin/TCF/LEF signaling , whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways . Positive_regulation TCF7 CCND1 15893541 1407594 The increased protein level was *induced* through activation of the [transcription factor] , nuclear factor kB ( NFkappaB ) , in the NHBE cells . Positive_regulation TCF7 CCND1 23135283 2707312 We find that knockdown of PAX2 inhibits the activity of AP-1 , a [transcription factor] that *induces* expression , implying that PAX2 induces cyclin D1 through AP-1 . Positive_regulation TCF7 CCND1 24979278 2947646 Thus , full activation of promoter activity *requires* ß-catenin activation of [TCF-lef] and stabilization of specific p120 catenin isoforms to relieve the repression of KAISO . Positive_regulation TCF7 CCND1 7970707 280073 *Activation* of the E2F [transcription factor] by is blocked by p16INK4 , the product of the putative tumor suppressor gene MTS1 . Positive_regulation TCF7 CTGF 15601748 1361753 K252a , a known selective inhibitor of Trk , blocked this phosphorylation , induced *activation* of signaling proteins , and CTGF dependent induction of the [transcription factor] TGF-beta-inducible early gene in HMC . Positive_regulation TCF7 EPHB2 11784711 922015 Superoxide mediates shock wave induction of *dependent* osteogenic [transcription factor] ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors . Positive_regulation TCF7 EPHB2 11880483 919403 BDNF-LTP was further coupled to *dependent* phosphorylation of the [transcription factor] cAMP response element binding protein . Positive_regulation TCF7 EPHB2 15089040 1237822 Several reports indicate that the activation of extracellular signal regulated kinase ( ) *induces* microphthalmia associated [transcription factor] ( MITF ) degradation . Positive_regulation TCF7 EPHB2 15253728 1271687 *induces* increases in activator protein-1 (AP-1) [transcription factor] activity which may augment mesangial cell proliferation and ECM protein production . Positive_regulation TCF7 EPHB2 17117479 1677441 Finally , we show that activated *induced* increased expression of the Egr-1 [transcription factor] , which then bound to the promoter region of p35 . Positive_regulation TCF7 EPHB2 19910471 2189318 Active *increases* expression and activity of the c-Jun [transcription factor] , linking ERK and Jun N-terminal kinase (JNK) cascades . Positive_regulation TCF7 EPHB2 21144616 2419335 Receptors that belong to the family of death-receptors including TNF receptor-1 (TNF-R1) , CD95 ( Fas , APO-1 ) and TRAIL receptors ( TRAIL-R1 , TRAIL R2/DR4/DR5 ) transduce signals resulting in entirely different biological outcomes : They promote cell death via apoptosis but are also capable of inducing anti-apoptotic signals through the [transcription factor] nuclear factor NF-?B or *activation* of the proliferative protein kinase cascade resulting in cell protection and tissue regeneration . Positive_regulation TCF7 EPHB2 21890597 2506387 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and dependent *activation* of the CCAAT/enhancer binding protein beta [transcription factor] independent of p53 . Positive_regulation TCF7 EPHB2 24085800 2902616 SDF-1/CXCR4 could upregulate avß6 expression through phosphorylation of and *activation* of Ets-1 [transcription factor] . Positive_regulation TCF7 EPHB2 8657129 364844 Analysis of the *stimulated* ETS [transcription factor] ER81 . Positive_regulation TCF7 FBXO32 18367868 1898776 FoxO3 [transcription factor] causes marked atrophy in adult skeletal muscle and *induces* the muscle-specific ubiquitin ligase ( 1 ) In addition , we recently reported that FoxO3 is necessary and sufficient for the induction of autophagy in skeletal muscle . Positive_regulation TCF7 HBEGF 23909989 2861570 Heparin-binding-epidermal growth factor ( ) down-regulates Claudin-3 expression , but *enhances* [transcription factor] Snail expression . Positive_regulation TCF7 IL1B 10816656 580258 Since the molecular basis of these antiinflammatory effects is not well known , the influence of alpha-MSH on induced chemokine production and [transcription factor] *activation* was investigated in human keratinocytes . Positive_regulation TCF7 IL1B 15217752 1263821 However , the contribution by p38 to the induction of inducible nitric oxide synthase (iNOS) and apoptosis is independent of NF-kappaB nuclear translocation since SB203580 does not prevent *induced* DNA binding of this [transcription factor] . Positive_regulation TCF7 IL1B 16326073 1553778 induced NF-kappaB activation in Caco-2 cells , *promoting* the binding of this [transcription factor] to DNA and increasing NF-kappaB dependent transcription . Positive_regulation TCF7 IL1B 16569740 1568488 OTR promoter contains putative [transcription factor] binding sites for activating protein-1 (AP-1) , CCAAT/enhancer binding protein (C/EBP) , and nuclear factor-kappaB (NF-kappaB) , which may be *activated* by , whose concentrations increase with labor . Positive_regulation TCF7 IL1B 16855208 1632221 The induced expression of human prostaglandin F2alpha receptor messenger RNA in human myometrial derived ULTR cells *requires* the [transcription factor] , NFkappaB . Positive_regulation TCF7 IL1B 18996492 2016034 Our results revealed that IL-1beta induced PBEF expression in pulmonary vascular endothelial cells at the transcriptional level and a -1535 T-variant in the human PBEF gene promoter significantly attenuated its binding to an *induced* unknown [transcription factor] . Positive_regulation TCF7 IL1B 8626526 360409 [Transcription factor] binding to the ATF/cAMP-responsive element consensus sequence was *increased* 4-5-fold by acetylsphingosine , PMA , or , whereas binding to the CCAAT/enhancer binding protein and AP-1 elements was found to be only slightly stimulated by these three agents . Positive_regulation TCF7 IL1B 8798568 381641 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by plus tumor necrosis factor-alpha , and its full induction *requires* the presence of the [transcription factor] , c-FOS . Positive_regulation TCF7 IL1B 9950608 589789 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to , tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Positive_regulation TCF7 ITGB2 15886116 1406829 Vav1 is required for TCR induced calcium flux , activation of the ERK MAP kinase pathway , *activation* of the NF-kappaB [transcription factor] , inside-out activation of the integrin , TCR clustering , and polarisation of the T cell . Positive_regulation TCF7 JAG1 16973960 1673634 and Delta-1 equally *activated* CBF-1/RBPJkappa [transcription factor] , which is a major Notch target . Positive_regulation TCF7 JAG1 17568183 1815685 [WNT-beta-catenin-TCF/LEF] signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , and DKK1 genes . Positive_regulation TCF7 NES 23524971 2761891 The function of WNT signaling is primarily mediated by [TCF7] , which directly *induces* expression of Sox2 and . Positive_regulation TCF7 NGFR 7536747 300282 In the case of purified Schwann cells , treatment with TGF-beta 1 increases their proliferation , and it promotes a pre- or nonmyelinating Schwann cell phenotype characterized by increased NCAM expression , decreased expression , inhibition of the forskolin mediated induction of the myelin protein P0 , and *induction* of the Schwann cell [transcription factor] suppressed cAMP-inducible POU protein . Positive_regulation TCF7 PTGER2 11706038 896753 We now report that the and EP(4) prostanoid receptors , which couple to Galpha ( s ) , also *activate* [Tcf/Lef] signaling . Positive_regulation TCF7 TCN1 18501609 1928133 Therefore , deficient may *lead* to abnormal expression of [TCF] . Positive_regulation TCF7 TLR7 19122179 2037179 signaling via p38 *led* to phosphorylation and activation of the transcription factor Microphthalmia [transcription factor] , acting at E-box elements in the Ctsk promoter . Positive_regulation TCF7 TNF 10075082 594846 Suppression of *activated* nuclear [transcription factor-kappaB] , activator protein-1 , c-Jun N-terminal kinase , and apoptosis by beta-lapachone . Positive_regulation TCF7 TNF 11093734 755018 Tumor necrosis factor alpha (TNF-alpha) binding to the initiates apoptosis and simultaneously *activates* the [transcription factor] , nuclear factor-kappaB (NF-kappaB) , which suppresses apoptosis by an unknown mechanism . Positive_regulation TCF7 TNF 11572998 864823 This study examines the effect of a triterpene mixture ( F094 ) and a single molecular species ( avicin G ) isolated from the mixture on *induced* activation of nuclear [transcription factor-kappaB] ( NF-kappaB ) in Jurkat cells ( human T cell leukemia ) . Positive_regulation TCF7 TNF 12091427 960131 Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB , whereas potently *induced* this [transcription factor] . Positive_regulation TCF7 TNF 12604246 1062600 Stimulation of the VECs with *led* to an increase in the DNA binding activity of the [transcription factor] , nuclear factor-kappa binding protein ( NF-kappaB ) and the induction of the adhesion molecule ( ICAM)-1 . Positive_regulation TCF7 TNF 12633744 1068275 Furthermore , treatment of HAEC with 0.5 mM DFO or NC completely inhibited induced *activation* of the [transcription factor] , specificity protein-1 (SP-1) , but only partially inhibited or did not affect activation of other transcription factors known to regulate adhesion molecule expression , i.e. , nuclear factor kappaB (NFkappaB) , activator protein-1 (AP-1) , and interferon regulatory factor-1 (IRF-1) . Positive_regulation TCF7 TNF 12810554 1102600 also *impairs* the ability of IGF-I to induce expression of a key myogenic [transcription factor] , myogenin . Positive_regulation TCF7 TNF 12890427 1117246 At the molecular level , EXPLY-37 did not inhibit the *activation* of the nuclear factor kappa B (NF-kappaB) [transcription factor] by . Positive_regulation TCF7 TNF 12893683 1135166 Ginkgo biloba extract inhibits induced reactive oxygen species generation , [transcription factor] *activation* , and cell adhesion molecule expression in human aortic endothelial cells . Positive_regulation TCF7 TNF 14646597 1173183 *induced* activation of both c-jun NH ( 2 ) -terminal kinase ( JNK ) and nuclear [transcription factor-kappaB] ( NF-kappaB ) in 3T3-L1 cells . Positive_regulation TCF7 TNF 15374848 1323853 Carvedilol inhibits *induced* endothelial [transcription factor] activation , adhesion molecule expression , and adhesiveness to human mononuclear cells . Positive_regulation TCF7 TNF 15593122 1361702 In the colons , a *inducing* [transcription factor] , LPS induced TNF-alpha factor (LITAF) , was inhibited by 1,25D3 , but not by calcium . Positive_regulation TCF7 TNF 15753227 1380082 and glucose *induced* a dose- and time dependent activation of the p38 MAP kinase , the downstream kinase mitogen- and stress activated kinase 1 , and the [transcription factor] cAMP-responsive element binding protein ( CREB ) , in EPCs . Positive_regulation TCF7 TNF 16006484 1459248 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the [transcription factor] ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TCF7 TNF 16046706 1438306 Palmitate activates the NF-kappaB [transcription factor] and *induces* IL-6 and expression in 3T3-L1 adipocytes . Positive_regulation TCF7 TNF 16338458 1503938 EMSA indicated *induced* binding of the inflammatory [transcription factor] to an NFkappaB consensus sequence and to the NFkappaB recognition site located in the PAI-1 promoter . Positive_regulation TCF7 TNF 16978650 1633543 Peptide YY reverses *induced* [transcription factor] binding of interferon regulatory factor-1 and p53 in pancreatic acinar cells . Positive_regulation TCF7 TNF 17035338 1674533 Taken together , our data suggest that the produced in response to IFN-gamma is *required* for iNOS induction by activating NF-kappaB [transcription factor] . Positive_regulation TCF7 TNF 17210691 1681514 The survival mechanism requires nuclear factor-kappaB (NF-kappaB) [transcription factor] activity , which is strongly *induced* by in these cells . Positive_regulation TCF7 TNF 17449583 1730007 Quercetin inhibits *induced* NF-kappaB [transcription factor] recruitment to proinflammatory gene promoters in murine intestinal epithelial cells . Positive_regulation TCF7 TNF 18094051 1869013 We find that NGF can *induce* synthesis through the nuclear factor-kappaB [transcription factor] . Positive_regulation TCF7 TNF 19138739 2037795 We examined whether or not 1alpha,25- ( OH ) ( 2 ) D ( 3 ) inhibits the induced *activation* of nuclear [transcription factor-kappaB] ( NF-kappaB ) , which is essential for the expression of proinflammatory cytokines in HCAEC , by ELISA . Positive_regulation TCF7 TNF 20133051 2242220 In the search of the molecular mechanisms responsible for the sensitization effect of chrysin , we discovered that such sensitization is closely associated with the inhibitory effect of chrysin on *mediated* nuclear [transcription factor-kappaB] ( NF-kappaB ) activation . Positive_regulation TCF7 TNF 20617556 2286550 Overexpression of the p65/RelA subunit of NF-kappaB , a *activated* inflammatory [transcription factor] , in A7r5 cells , upregulated SIRT1 mRNA and protein expression as well as SIRT1 promoter activity , while knockdown of endogenous p65/RelA expression by RNAi not only led to a decrease in SIRT1 's basal protein expression and promoter activity , but almost abolished the TNF-alpha induced elevation of SIRT1 protein expression and SIRT1 promoter activity . Positive_regulation TCF7 TNF 2104232 150542 *induces* binding of the NF-kappa B [transcription factor] to a high-affinity kappa B element in the TNF-beta promoter . Positive_regulation TCF7 TNF 21389273 2443507 Functionally , TNF-a stimulated H ( 2 ) O ( 2 ) production was also blocked by MCD and DES ( 194.6 ± 15.4 % vs. 90.6 ± 15.9 % and 148.8 ± 20.4 % ) , and the *activation* of the pivotal proinflammatory [transcription factor] , NF-?B , by was reversed by MCD and DES as well as by small interfering RNAs of Duox1 or ASMase . Positive_regulation TCF7 TNF 21514273 2428760 We found that transiently *increased* Msx2 expression as well as the expression of canonical Wnt signaling molecules , including Wnt3a , Wnt7a , Wnt7b , Wnt10b , low-density lipoprotein receptor related protein 5 ( LRP5 ) and [T-cell factor 1 (TCF1)] . Positive_regulation TCF7 TNF 21541574 407731 These results are in contrast to those reported for the murine p53 gene , whose promoter is *induced* by through activation of the NF-kappa B [transcription factor] . Positive_regulation TCF7 TNF 8798568 381640 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by interleukin-1beta plus , and its full induction *requires* the presence of the [transcription factor] , c-FOS . Positive_regulation TCF7 TNF 9582369 504187 Overexpression of manganese superoxide dismutase suppresses *induced* apoptosis and activation of nuclear [transcription factor-kappaB] and activated protein-1 . Positive_regulation TCF7 TNF 9794740 543105 To determine whether the [transcription factor] nuclear factor-kappaB mediated expression of these genes involved in the inflammatory *response* of endothelial cells to , by using transcription factor decoy oligodeoxynucleotides . Positive_regulation TCF7 TNF 9950608 589787 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to interleukin-1beta (IL-1beta) , , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Positive_regulation TCF7 TP63 21741828 2599106 In this study we show that *induces* the expression of the basal epithelial [transcription factor] , Basonuclin 1 . Positive_regulation TCF7 WNT7A 11782388 900398 Coculture experiments demonstrated that Wnt-1 , but not Wnt-5A and , *activated* the [TCF] reporter gene . Positive_regulation TCF7 WNT7A 17431004 1748947 *stimulated* a [TCF/LEF-luciferase] reporter activity in ovine trophectoderm cells that was inhibited by dominant negative TCF and Sfrp2 ( secreted FZD related protein 2 ) . Positive_regulation TCF7 ZFP57 19234145 2072233 The other was the 5 ' noncoding region of a [transcription factor] , Zfp423 , which *induced* aberrant expression . Positive_regulation TCF7L2 AXIN2 20122174 2213273 Expression of or AxinDeltap53 downregulates beta-catenin and TCF-4 , and knock-down of beta-catenin *upregulates* [TCF-4] in BE1 cells . Positive_regulation TCF7L2 TNF 20804741 2341701 siRNA knock down of ß-catenin abrogated *induced* uPA expression as well as [Tcf-4/ß-catenin] DNA binding . Positive_regulation TCHP S100B 17010455 1647573 The interaction between S100B and the Hdm2 and/or the Hdm4 proteins may be important physiologically in light of evidence that like Hdm2 , also *contributes* to lowering protein levels of the [tumor suppressor protein] , p53 . Positive_regulation TCL1A ABCG2 20683952 2299075 We further demonstrate that Oct4 overexpression induced activation of [TCL1] , AKT , and to *mediate* chemoresistance , which can be overcome by addition of the PI3K/AKT inhibitor ; Positive_regulation TCN1 ACD 23406759 2713280 resulting from exposure to low molecular weight chemicals is a common clinical condition in industrialized countries and can be *mediated* by either Th1 or [Tc1] lymphocytes . Positive_regulation TCN1 ADK 3698043 58991 A *requirement* for activity for activation of both [TCN] and TCN-P was established by the observation that growth inhibition by either compound was decreased 200-fold by the adenosine kinase inhibitor 5-iodotubercidin and greater than 5000-fold in L1210/T , an adenosine kinase-deficient subline . Positive_regulation TCN1 CD79A 11163403 763135 [TCI] *induced* only modest levels of in any of the samples tested ( range 2-7 fold increase ) . Positive_regulation TCN1 CHUK 19684084 2132983 [TC1] is up-regulated by IL-1beta , TNF-alpha , LPS , and phorbol ester , and the up-regulation is *inhibited* by inhibitors . Positive_regulation TCN1 FASLG 14729652 1198599 Effector cell derived lymphotoxin alpha and , but not perforin , *promote* [Tc1] and Tc2 effector cell mediated tumor therapy in established pulmonary metastases . Positive_regulation TCN1 FASLG 14729652 1198601 Collectively , tumor antigen-specific [Tc1] and Tc2 effector cell mediated therapy is initially *dependent* , in part , on effector cell derived or LTalpha that may subsequently potentiate endogenous recipient derived type 1 antitumor responses dependent on TNF-alpha and IFN-gamma . Positive_regulation TCN1 HNRNPF 16531121 1555227 We showed that adenovirus infection had no further effect on the phenotype , the ability to *induce* IFN-gamma producing [Th1/Tc1] response or the T cell stimulatory capacity of already mature in vitro . Positive_regulation TCN1 HNRNPF 24296809 2921387 Functionally , OK-432 plus IFN-? conditioned *induce* remarkable Th1 and [Tc1] responses more effectively than OK-432 alone , even more than the use of a-type-1 cytokine cocktail . Positive_regulation TCN1 HNRNPH1 16531121 1555228 We showed that adenovirus infection had no further effect on the phenotype , the ability to *induce* IFN-gamma producing [Th1/Tc1] response or the T cell stimulatory capacity of already mature in vitro . Positive_regulation TCN1 HNRNPH1 24296809 2921388 Functionally , OK-432 plus IFN-? conditioned *induce* remarkable Th1 and [Tc1] responses more effectively than OK-432 alone , even more than the use of a-type-1 cytokine cocktail . Positive_regulation TCN1 IGF1 8691111 372678 *stimulated* [TC-1] DNA synthesis in a dose dependent manner and this effect was inhibited by recombinant IGFBP-1 and -4 . Positive_regulation TCN1 IGF1 8858604 388454 The [total cell number (TCN)] , TE number , and ICM cell number were significantly higher in blastocysts developed in vitro in the *presence* of as compared to blastocysts developed without IGF-I ( P < 0.01 ) . Positive_regulation TCN1 IL12A 22215017 2559032 pulsed with tumor antigen derived peptides and injected as a therapy distal to the tumor site prevented tumor growth and *activated* robust antigen-specific [Tc1] responses . Positive_regulation TCN1 IL12B 22215017 2559033 pulsed with tumor antigen derived peptides and injected as a therapy distal to the tumor site prevented tumor growth and *activated* robust antigen-specific [Tc1] responses . Positive_regulation TCN1 IL1B 19684084 2132984 [TC1] is *up-regulated* by , TNF-alpha , LPS , and phorbol ester , and the up-regulation is inhibited by I-kappaB-kinase inhibitors . Positive_regulation TCN1 LRP2 11832420 910211 is *essential* for renal proximal tubule reabsorption and accumulation of [transcobalamin-B(12)] . Positive_regulation TCN1 LTA 14729652 1198600 Effector cell derived and Fas ligand , but not perforin , *promote* [Tc1] and Tc2 effector cell mediated tumor therapy in established pulmonary metastases . Positive_regulation TCN1 LTA 14729652 1198602 Collectively , tumor antigen-specific [Tc1] and Tc2 effector cell mediated therapy is initially *dependent* , in part , on effector cell derived FasL or that may subsequently potentiate endogenous recipient derived type 1 antitumor responses dependent on TNF-alpha and IFN-gamma . Positive_regulation TCN1 MAGEA4 23124083 2696271 Both and Survivin-H/K-HELP cancer vaccine *induced* cancer-specific Th1 and [Tc1] immune responses and cancer-specific C-fixing antibodies ( IgG1 and IgG3 ) in cancer patients . Positive_regulation TCN1 NELFCD 18088457 1838014 Though the level in T cells of AML patients in complete remission is low , but [Tc1] response is even *enhanced* as high as the healthy controls . Positive_regulation TCN1 PTBP1 16531121 1555229 We showed that adenovirus infection had no further effect on the phenotype , the ability to *induce* IFN-gamma producing [Th1/Tc1] response or the T cell stimulatory capacity of already mature in vitro . Positive_regulation TCN1 PTBP1 24296809 2921389 Functionally , OK-432 plus IFN-? conditioned *induce* remarkable Th1 and [Tc1] responses more effectively than OK-432 alone , even more than the use of a-type-1 cytokine cocktail . Positive_regulation TCN1 PTBP2 16531121 1555226 We showed that adenovirus infection had no further effect on the phenotype , the ability to *induce* IFN-gamma producing [Th1/Tc1] response or the T cell stimulatory capacity of already mature in vitro . Positive_regulation TCN1 PTBP2 24296809 2921386 Functionally , OK-432 plus IFN-? conditioned *induce* remarkable Th1 and [Tc1] responses more effectively than OK-432 alone , even more than the use of a-type-1 cytokine cocktail . Positive_regulation TCN1 TNFRSF9 20731035 2313346 Co-stimulatory molecule can *enhance* the [Tc1] ( type I ) cell mediated immunity , HBsAg-specific CTL and memory responses induced by HBsAg DNA vaccine , and may be an efficient adjuvant in priming HBV-specific T cell response . Positive_regulation TCP1 CAPN8 12857760 1141816 Forced expression of or exposure of cells to the calcium ionophore , A23187 , *increased* [CCTalpha] degradation , whereas overexpression of the endogenous calpain inhibitor , calpastatin , attenuated Ox-LDL induced CCTalpha degradation . Positive_regulation TCP1 CAPN8 16511521 1567793 Pseudomonas aeruginosa ( PA103 ) decreased DPPC synthesis , in part , via *mediated* degradation of [CCTalpha] . Positive_regulation TDGF1P3 CD14 1708813 155182 Interaction of with LPS in the presence of LBP or serum also *caused* a dramatic , transient increase in the adhesive activity of [CR3] ( CD11b/CD18 ) on PMN . Positive_regulation TDGF1P3 CD14 8543790 346207 We speculate that LPS charged *enhances* [CR3] mediated adhesion by directly binding to CR3 . Positive_regulation TDGF1P3 ITGB2 1673986 155030 A direct *role* for phosphorylation in the activation of [CR3] for phagocytosis is consistent with these data . Positive_regulation TDGF1P3 ITGB2 2978519 104114 mediates the binding of killer T cells to targets , CR3 mediates binding of phagocytes to iC3b coated surfaces and to endothelial cells , and LFA-1 , [CR3] , and p150 ,95 each *mediate* the binding of bacterial lipopolysaccharide . Positive_regulation TDGF1P3 SELL 1709677 158038 *stimulates* the adhesive activity of leukocyte integrin [CR3] ( CD11b/CD18 , Mac-1 , alpha m beta 2 ) on human neutrophils . Positive_regulation TDGF1P3 TNF 11529937 853681 Furthermore , induced about a three-fold *increase* in the expression of [CR3] in neutrophils , an effect which is blocked by the p38 MAPK inhibitor . Positive_regulation TDGF1P3 TNF 1349613 185985 Immunofluorescence of macrophages indicated that *caused* a reduced expression of the [CR3] by phagocytic cells . Positive_regulation TDGF1P3 TNF 16239529 1471083 and gamma interferon ( IFN-gamma ) *increased* [CR3] surface expression , but only TNF-alpha increased the ability of neutrophils to phagocytose B. pertussis , suggesting that elevated CR3 expression alone is not sufficient to promote phagocytosis . Positive_regulation TDGF1P3 TNF 1972179 135345 Unlike PMNs , EOs were not irreversibly activated to kill unopsonized endothelium by previous exposure to TNF , and did not degranulate or upregulate [CR3] expression as detected by Mo1 in the *presence* of 100 U/ml . Positive_regulation TDGF1P3 TNF 2961377 84133 Recombinant IL-1 had no effect on receptor expression , but recombinant *increased* CR1 and [CR3] expression with kinetics similar to the supernatants . Positive_regulation TDGF1P3 TNF 8409440 233439 *increased* the expression of [CR3] ( CD11b/CD18 ) and CR4 ( P150 , 95 ; Positive_regulation TDGF1P3 TNF 8898723 393099 Macrophage phagocytosis of myelin in vitro determined by flow cytometry : phagocytosis is mediated by [CR3] and *induces* production of and nitric oxide . Positive_regulation TDGF1P4 TNF 8409440 233440 *increased* the expression of CR3 ( CD11b/CD18 ) and [CR4] ( P150 , 95 ; Positive_regulation TDP1 PLAT 8822928 384863 In addition , a turbidity assay was used to determine the effect of APC on *induced* fibrinolysis of clots produced from normal human plasma ( NHP ) , plasma immunodepleted of TAFI ( TdP ) , and [TdP] reconstituted with purified TAFI . Positive_regulation TDP2 PLAT 8822928 384862 In addition , a turbidity assay was used to determine the effect of APC on *induced* fibrinolysis of clots produced from normal human plasma ( NHP ) , plasma immunodepleted of TAFI ( TdP ) , and [TdP] reconstituted with purified TAFI . Positive_regulation TEAD4 CTGF 22329991 2565705 Expression of in MM cells was *induced* by the formation of a [YAP-TEAD4-Smad3-p300] complex on the CTGF promoter . Positive_regulation TEC FAS 10194446 603881 This apoptosis was inhibited by Z-VAD-fmk but not by Z-DEVD-fmk and DEVDase activity was slightly increased in *stimulated* [TEC] , suggesting that DEVDase activity is not sufficient to induce TEC apoptosis . Positive_regulation TEC TNF 18480171 1933389 Indoleamine 2,3-dioxygenase (IDO) catabolizes tryptophan to N-formyl kynurenine and has a proapoptotic role in renal [tubular epithelial cells (TEC)] in *response* to IFN-gamma and in vitro . Positive_regulation TEC TNF 1902846 156089 On the other hand , plus IFN gamma *induced* [TEC] HLA-DR expression on both types of thyroid xenografts at death , although IL-2 alone did not induce HLA-DR expression , and IFN gamma induced TEC significantly only on normal thyroid xenografts ( but not on Graves ' xenografts ) . Positive_regulation TEC TNF 9647261 515005 By comparison , *induces* apoptosis in MC , but not [TEC] , of the MRL-Fas ( lpr ) strain . Positive_regulation TECR CLDN10 24114540 2863675 Downregulation of by siRNA *resulted* in the decrease of SCC and PD , but not [TER] , in B4G12 cells . Positive_regulation TECR EPHB2 18787064 1980743 Inhibition of *prevented* the BiCM induced increase in [TER] and attenuated the protection from TNF-alpha and IFN-gamma . Positive_regulation TECR MAP2K6 19955189 2210218 The pathway inhibitor , U0126 , *reduced* the SRL , CsA , and CsA/SRL induced increase in [TER] . Positive_regulation TECR SLC9A2 18719001 1974950 In contrast to prior porcine studies , pharmacological inhibition of in postischemic tissues from wild-type mice also *resulted* in significant reductions in [TER] . Positive_regulation TECR SNCAIP 11544274 855259 produced rapid , sustained , and dose dependent *increases* in transmonolayer electrical resistance ( [TER] ) across both human and bovine pulmonary artery and lung microvascular endothelial cells . Positive_regulation TEK ANGPT1 10521483 653142 Furthermore , stimulation of Tek expressing cells with *results* in phosphorylation of both [Tek] and p85 and in activation of endothelial cell migration and survival pathways that are dependent in part on phosphatidylinositol 3-kinase . Positive_regulation TEK ANGPT1 9723709 529259 Two recently identified [TEK] ligands , termed Angiopoietin-1 and -2 , bound to TEK with similar affinities , and effectively *induced* TEK phosphorylation in hematopoietic cells . Positive_regulation TERF1 EPHB2 12402047 1009413 We conclude that cAMP induced regulation of and *activation* of [Rap1] are independent processes . Positive_regulation TERF1 F2R 15078882 1251914 Concomitant stimulation of both and PAR-4 in the presence of ADP scavengers still *resulted* in a strongly reduced activation of [Rap1B] . Positive_regulation TERF1 FLG 17045653 1666567 Using a Rap1-GTP pull-down assay , we found that stimulation , but not LPS , of avian heterophils *induced* a rapid and transient [Rap1] activation . Positive_regulation TERF1 FLG 17045653 1666588 We show here that stimulation of heterophils *induces* the phosphorylation of [Rap1] . Positive_regulation TERF1 ITGAL 24486015 2928141 The gap junction protein connexin43 (Cx43) regulates B lymphocyte adhesion , BCR- and mediated *activation* of the GTPase [Rap1] , and cytoskeletal rearrangements resulting in changes to cell shape and membrane spreading . Positive_regulation TERF1 PECAM1 10725328 677537 Importantly , selectively *activated* the small Ras related GTPase , [Rap1] , but not Ras , R-Ras , or Rap2 . Positive_regulation TERF2 EPHB2 12402047 1009414 We conclude that cAMP induced regulation of and *activation* of [Rap1] are independent processes . Positive_regulation TERF2 EPHB2 15178807 1280487 TPA treatment rapidly increased phosphorylation of , a reported downstream effector of both PKC and Rap1 , in ERC-18 cells , but induced weak [Rap1] *activation* . Positive_regulation TERF2 F2R 15078882 1251872 We found that , similarly to thrombin , selective stimulation of either or PAR-4 by specific activating peptides *caused* accumulation of GTP bound [Rap1B] in a dose dependent manner . Positive_regulation TERF2 F2R 15078882 1251886 In the presence of the ADP scavengers apyrase or phosphocreatine-phosphocreatine kinase , activation of [Rap1B] *induced* by stimulation of either or PAR-4 was totally inhibited . Positive_regulation TERF2 F2R 15078882 1251916 Concomitant stimulation of both and PAR-4 in the presence of ADP scavengers still *resulted* in a strongly reduced activation of [Rap1B] . Positive_regulation TERF2 F2R 19483102 2107923 Perturbation of PI3K signaling by isoform-selective inhibitors had differential effects on [Rap1] *activation* through and PAR4 . Positive_regulation TERF2 F2R 24790104 2950501 Stimulation of the G-protein coupled receptor with thrombin in human 1321N1 glioblastoma cells *led* to a robust increase in [Rap1] activation . Positive_regulation TERF2 FLG 17045653 1666568 Using a Rap1-GTP pull-down assay , we found that stimulation , but not LPS , of avian heterophils *induced* a rapid and transient [Rap1] activation . Positive_regulation TERF2 FLG 17045653 1666589 We show here that stimulation of heterophils *induces* the phosphorylation of [Rap1] . Positive_regulation TERF2 ITGAL 24486015 2928142 The gap junction protein connexin43 (Cx43) regulates B lymphocyte adhesion , BCR- and mediated *activation* of the GTPase [Rap1] , and cytoskeletal rearrangements resulting in changes to cell shape and membrane spreading . Positive_regulation TERF2 PECAM1 10725328 677538 Importantly , selectively *activated* the small Ras related GTPase , [Rap1] , but not Ras , R-Ras , or Rap2 . Positive_regulation TERF2 TNF 16043520 1437846 Both compounds blocked induced *activation* of [Rap1A] , a phox associated guanosine triphosphatase that is regulated by cAMP . Positive_regulation TERF2IP EPHB2 12402047 1009417 We conclude that cAMP induced regulation of and *activation* of [Rap1] are independent processes . Positive_regulation TERF2IP EPHB2 15178807 1280489 TPA treatment rapidly increased phosphorylation of , a reported downstream effector of both PKC and Rap1 , in ERC-18 cells , but induced weak [Rap1] *activation* . Positive_regulation TERF2IP F2R 15078882 1251876 We found that , similarly to thrombin , selective stimulation of either or PAR-4 by specific activating peptides *caused* accumulation of GTP bound [Rap1B] in a dose dependent manner . Positive_regulation TERF2IP F2R 15078882 1251890 In the presence of the ADP scavengers apyrase or phosphocreatine-phosphocreatine kinase , activation of [Rap1B] *induced* by stimulation of either or PAR-4 was totally inhibited . Positive_regulation TERF2IP F2R 15078882 1251922 Concomitant stimulation of both and PAR-4 in the presence of ADP scavengers still *resulted* in a strongly reduced activation of [Rap1B] . Positive_regulation TERF2IP F2R 19483102 2107927 Perturbation of PI3K signaling by isoform-selective inhibitors had differential effects on [Rap1] *activation* through and PAR4 . Positive_regulation TERF2IP F2R 24790104 2950503 Stimulation of the G-protein coupled receptor with thrombin in human 1321N1 glioblastoma cells *led* to a robust increase in [Rap1] activation . Positive_regulation TERF2IP FLG 17045653 1666571 Using a Rap1-GTP pull-down assay , we found that stimulation , but not LPS , of avian heterophils *induced* a rapid and transient [Rap1] activation . Positive_regulation TERF2IP FLG 17045653 1666592 We show here that stimulation of heterophils *induces* the phosphorylation of [Rap1] . Positive_regulation TERF2IP ITGAL 24486015 2928145 The gap junction protein connexin43 (Cx43) regulates B lymphocyte adhesion , BCR- and mediated *activation* of the GTPase [Rap1] , and cytoskeletal rearrangements resulting in changes to cell shape and membrane spreading . Positive_regulation TERF2IP PECAM1 10725328 677541 Importantly , selectively *activated* the small Ras related GTPase , [Rap1] , but not Ras , R-Ras , or Rap2 . Positive_regulation TERF2IP TNF 16043520 1437848 Both compounds blocked induced *activation* of [Rap1A] , a phox associated guanosine triphosphatase that is regulated by cAMP . Positive_regulation TERT EPHB2 14708611 1181140 Inhibition of , Src , or Akt *suppressed* [telomerase] activity in HSC-1 cells , but to a lesser extent than did treatment with AG 1478 . Positive_regulation TERT ID1 10449746 637375 We demonstrate that ectopic expression of *leads* to activation of [telomerase] activity and immortalization of primary human keratinocytes . Positive_regulation TERT ID1 10908559 722490 Under these experimental conditions , expression did not *trigger* induction of [telomerase] activity , and there was progressive shortening of the telomeres that was accompanied by elevated p16 levels and prevalence of active Rb . Positive_regulation TERT IFI27 14612944 1163392 Overexpression of *suppressed* [telomerase] activity in tumor cells . Positive_regulation TERT RARB 14586406 1159564 Our previous work showed that acquisition of immortality at the dysplasia stage of oral cancer progression was consistently associated with four changes : loss of and p16INK4A expression , p53 mutations and *activation* of [telomerase] . Positive_regulation TERT TNF 15020249 1221496 *induces* rapid activation and nuclear translocation of [telomerase] in human lymphocytes . Positive_regulation TERT TNF 15020249 1221512 In this study , we show that tumor necrosis factor alpha (TNFalpha) induces telomerase activity in the cytoplasm of peripheral blood lymphocytes ( PBL ) at 60 min , followed by translocation of activated telomerase to the nucleus at 120 min. Conversely , the phosphoinositol 3-kinase (PI3K) inhibitor wortmannin blocks induced *activation* of [telomerase] , whereas the specific NF-kappaB translocation inhibitor SN-50 blocks TNFalpha induced nuclear translocation of activated telomerase . Positive_regulation TERT TNF 15326480 1296843 The present study described that , in the leukemic KG1 cells , *induced* no apoptosis but a senescence state characterized by prolonged growth arrest , increased beta-galactosidase activity , p21WAF-1 induction , decreased [telomerase] activity , telomeric disturbances ( shortening , losses , fusions ) , and additional chromosomal aberrations . Positive_regulation TERT TNF 19299722 2051936 Here , we show that modulation of levels in long-term cultures of human CD8 ( + ) T lymphocytes , by chronic exposure either to a neutralizing Ab or to an inhibitor of the TNF-alpha receptor-1 , increases proliferative potential , delays loss of CD28 expression , retards cytokine profile changes , and *enhances* [telomerase] activity . Positive_regulation TERT ZFP57 20235149 2244329 Constitutive expression of in C2C12 myoblasts *increased* mTERT expression and [telomerase] activity , and promoted the progression of the cell cycle and cell proliferation . Positive_regulation TF ACTN4 11466227 839789 The hypothesis tested in this study was that CBP/p300 is required for the synergistic *activation* of the [transferrin] promoter involving PRII and E-box through the formation of a . Positive_regulation TF AKR1B1 18549825 1945849 We previously found that lack of , the first enzyme of the polyol pathway , *attenuated* the increase in [transferrin (Tf)] level in I/R brain , suggesting that AR contributes to iron catalyzed free radical induced damage . Positive_regulation TF ALB 1747128 172023 Competitive assays of binding of Al3+ to [transferrin] in the *presence* of citrate and human at molar ratios corresponding to those found in normal plasma showed that a considerable amount of Al3+ was not bound to transferrin . Positive_regulation TF ALB 20203136 2243217 Competitive assays of binding of Cd ( 2+ ) to [transferrin] in the *presence* of citrate and human at molar ratios corresponding to those found in normal plasma showed that a considerable amount of Cd ( 2+ ) was not bound to transferrin . Positive_regulation TF ARF1 22998223 2726733 Depletion of both Arf6 and abolishes G-clathrin , and results in partial *inhibition* of fast [transferrin] recycling consistent with the latter 's participation in this pathway . Positive_regulation TF ARF6 22998223 2726734 Depletion of both and Arf1 abolishes G-clathrin , and results in partial *inhibition* of fast [transferrin] recycling consistent with the latter 's participation in this pathway . Positive_regulation TF CA2 2964376 90088 These proteins were not appreciably phosphorylated in quiescent cells , but were rapidly phosphorylated after growth stimulation by insulin , epidermal and fibroblast growth factors , [transferrin] , phorbol ester and diacylglycerol in the *presence* of , in a manner similar to that of MAP-1 related Mr 350,000 protein ( J. Cell Biol. 100 , 748-753 ) . Positive_regulation TF CALD1 20097166 2212827 This study demonstrates that *promoted* a transient block in the transport of two cellular glycoproteins , the [transferrin receptor (TfR)] and TNF-alpha . Positive_regulation TF CAMK2A 11466227 839788 The hypothesis tested in this study was that CBP/p300 is required for the synergistic *activation* of the [transferrin] promoter involving PRII and E-box through the formation of a . Positive_regulation TF CDR1 21903580 2496644 In this study , we used two erythroid models , murine erythroid leukemia cells and erythroid burst forming unit derived erythroblasts , to show that <5-aza-CdR> induced erythroid differentiation and *increased* the expression of [transferrin receptor 1 (TfR1)] and ferrochelatase (Fech) , thereby increasing iron uptake and heme biosynthesis . Positive_regulation TF CGA 8706718 373459 The transcription of the [transferrin (Tf)] gene is *induced* by via cAMP in rat Sertoli cells . Positive_regulation TF CHMP6 15511219 1380454 Overexpression of *caused* reduction of [transferrin] receptors on the plasma membrane surface , but caused their accumulation in the cytoplasm . Positive_regulation TF CP 9210294 441237 Furthermore , experiments demonstrate that at acidic pH the inhibitory effect of ascorbate on the rate of Fe ( 3+ ) [-transferrin] formation is not primarily *due* to an interaction with , but to a reduction of enzymically generated ferric ions before they are bound to apotransferrin . Positive_regulation TF CREB1 10067852 594001 These results suggest that optimal activation of the mouse [transferrin] promoter by FSH *requires* both binding to the CRE-like PRII region and bHLH binding to the E-box . Positive_regulation TF CREB3 10067852 594002 These results suggest that optimal activation of the mouse [transferrin] promoter by FSH *requires* both binding to the CRE-like PRII region and bHLH binding to the E-box . Positive_regulation TF CREB5 10067852 594000 These results suggest that optimal activation of the mouse [transferrin] promoter by FSH *requires* both binding to the CRE-like PRII region and bHLH binding to the E-box . Positive_regulation TF CSF2 15210846 1281509 Macrophage differentially *regulates* low density lipoprotein and [transferrin] receptors . Positive_regulation TF CSF3 1701357 145027 ( G-CSF ) *enhanced* surface [transferrin receptor (TfR)] expression in two human myeloid leukemia cell lines , NKM-1 and NOMO-1 , which possess G-CSF receptors . Positive_regulation TF CSNK2A1 7852847 294757 Activation of in ML-1 human myeloblastic leukemia cells *requires* IGF-1 and [transferrin] . Positive_regulation TF CSNK2A2 7852847 294758 Activation of in ML-1 human myeloblastic leukemia cells *requires* IGF-1 and [transferrin] . Positive_regulation TF CSNK2B 7852847 294759 Activation of in ML-1 human myeloblastic leukemia cells *requires* IGF-1 and [transferrin] . Positive_regulation TF EBF3 8297471 240917 In the uterus alone , produced a significant increase in the content of nucleic acids and also *induced* the accumulation of [transferrin] and beta-actin mRNAs . Positive_regulation TF EBF3 8297471 240921 We have detected for the first time an induction of [transferrin] gene expression in the mammary gland in *response* to , and these results support the view that the pattern of transferrin gene multi modulated expression is tissue- and species-specific . Positive_regulation TF EGF 6095297 42984 The *induced* increase in [transferrin] receptors was transient , reaching a peak by 5 min and then declining back to near basal levels by 45 min. Increases in transferrin receptor number were observed when approximately equal to 1 % of the EGF receptors were occupied and were maximal at 16 % occupancy . Positive_regulation TF EGF 8021875 263092 The ratio of polarized [transferrin] secretion in *response* to FSH , , or in combination was also examined . Positive_regulation TF EPO 9428699 474306 It was concluded from these experiments that the *stimulated* rise in [transferrin] receptors during the final stages of J2E cell maturation is linked to cell division , and is not essential for haemoglobin synthesis . Positive_regulation TF FGF2 14519096 1147709 As for transferrin production , while both MAPK kinase inhibitors partially decreased the ability of to *stimulate* [transferrin] secretion , the PI3K inhibitor did not modify it . Positive_regulation TF FSHB 8706718 373460 The transcription of the [transferrin (Tf)] gene is *induced* by via cAMP in rat Sertoli cells . Positive_regulation TF HAMP 19254564 2045162 Gao et al. ( 2009 ) make the key discovery that the regulation of in response to holotransferrin *requires* the interaction between HFE and [transferrin receptor 2 (TfR2)] . Positive_regulation TF HFE 11196670 762052 As a result , expression *leads* to an accumulation of non-functional [transferrin] receptors at the cell surface , and a decrease in iron uptake . Positive_regulation TF HRAS 2031324 159565 To summarize , E <1A+c-Ha-ras> oncogene transformed REF can grow independently of GF but still *require* [transferrin] . Positive_regulation TF HRES1 18432409 1900173 HRES-1/p28 is a nuclear autoantigen recognized by cross-reactive antiviral antibodies , while *regulates* surface expression of CD4 and the [transferrin receptor (TFR)] through endosome recycling . Positive_regulation TF HTR2C 1334504 205886 We conclude , therefore , that <5-HT1C> receptor activation in the choroid plexus *leads* to an increase in the production of [transferrin] . Positive_regulation TF HTR2C 2164094 136124 5-HT induced [transferrin] production by choroid plexus epithelial cells in culture : *role* of <5-HT1c> receptor . Positive_regulation TF HTR2C 2164094 136126 To determine if the effect on [transferrin] is also *mediated* by the <5-HT1c> receptor , the effects of 5-HT receptor agonists and antagonists were examined in choroid plexus epithelial cells in primary culture . Positive_regulation TF ID1 11316735 806528 Antisense to *stimulated* [transferrin] promoter activity in a transient transfection assay . Positive_regulation TF IFNG 3134021 94306 This suggests that in WISH cells , not only *reduced* the total number of [transferrin] receptors , but also modified the process of receptor internalization and recycling . Positive_regulation TF IGF1 14765977 1207477 In addition , the analysis of the participation of a MAPK pathway in IGF-I regulation of Sertoli cell biological responses showed that the MAPK kinase inhibitors , PD98059 and U0126 , decreased *stimulated* [transferrin] secretion while not modifying IGF-I stimulated lactate levels . Positive_regulation TF IKBKG 20214888 2230079 We also show that recruits DLIC-2 onto membranes and that DLIC-2 is *necessary* for the accumulation of [endocytosed-transferrin (Tfn)] at the pericentrosomal endosomal recycling compartment (ERC) . Positive_regulation TF IL18 18835036 2012810 [Transferrin] *induces* expression in chronic myeloid leukemia cell line , K-562 . Positive_regulation TF IL18 19535202 2162475 *induces* [transferrin] expression in breast cancer cell line MCF-7 . Positive_regulation TF IL18 19535202 2162477 Furthermore , we found that the MAPK pathway is involved in *induced* [transferrin] production . Positive_regulation TF IL1A 11900596 921700 *Induction* of [transferrin] secretion in murine Sertoli cells by FSH and : the possibility of different mechanism ( s ) of regulation . Positive_regulation TF IL1A 11900596 921701 In the present study we examined the capacity of , beta , interleukin-1 receptor antagonist ( IL-1ra ) and follicle stimulating hormone ( FSH ) to *induce* [transferrin] secretion by Sertoli cells under in vitro conditions . Positive_regulation TF IL1A 22932066 2785952 On the contrary , SB203580 was unable to block *induced* increase in [transferrin] secretion suggesting that the p38-MAPK pathway does not participate in the mechanism of action of the cytokine to regulate transferrin . Positive_regulation TF IL1B 16123165 1482257 In testicular Sertoli cells , *regulates* steroid , lactate , and [transferrin] secretion ; Positive_regulation TF IL1RN 11900596 921702 In the present study we examined the capacity of interleukin-1 (IL-1) alpha , beta , ( IL-1ra ) and follicle stimulating hormone ( FSH ) to *induce* [transferrin] secretion by Sertoli cells under in vitro conditions . Positive_regulation TF IL2 10573078 568749 [Transferrin receptor (TfR)] expression *follows* the induction of expression in a sequence that is necessary to initiate cell proliferation in quiescent T lymphocytes . Positive_regulation TF IL2 2105168 126875 Exogenous did not *increase* either IFN-gamma production or [transferrin receptor (TfR)] expression in the presence of calcitriol despite increases in cell entry into late G1 and proliferation . Positive_regulation TF IL2 2871125 58206 TGF-beta inhibited *induced* upregulation of the IL-2 and [transferrin] receptors . Positive_regulation TF IL2 8288726 240795 However , SAC + *induced* [transferrin] receptors normally in low-responders , showing that some early activation steps occur in these cells . Positive_regulation TF IL6 7695840 287943 Synthesis of albumin was slightly inhibited by and RA , and synthesis of [transferrin] was *increased* by RA but not by IL-6 . Positive_regulation TF INHBA 7867593 296461 In the presence of insulin and [transferrin] , *increased* both granulosa cell number and thymidine incorporation more than 2-fold . Positive_regulation TF INHBA 8033824 264142 *stimulated* both basal and FSH stimulated inhibin and [transferrin] production by Sertoli cells after 72 h of culture . Positive_regulation TF INS 1797590 176867 The transferrin ratio ( ratio of transferrin secreted into the upper over the lower chamber ) was decreased by and FSH but not by retinoic acid or testosterone , yet all four stimuli *increased* total [transferrin] secretion . Positive_regulation TF INS 2542008 112182 and retinol *stimulated* both [transferrin] and ABP synthesis in a similar manner . Positive_regulation TF INS 3066504 102726 In contrast , *caused* a prolonged stimulation of [transferrin] binding . Positive_regulation TF INS 3788717 66304 Experiments done with cultured Sertoli cells suggest that the [transferrin] mRNA levels are *regulated* by FSH , , vitamin A , and testosterone . Positive_regulation TF INS 6411361 30438 MSA and together *stimulated* [transferrin] secretion to the same extent as either hormone alone . Positive_regulation TF INS 8148400 252748 *increases* the diferric [transferrin] reductase response and increases growth stimulation with bombesin . Positive_regulation TF INS 8481893 218832 , alone or in combination with GM-CSF , *caused* an increase in surface [transferrin] receptors within 5 min . Positive_regulation TF KHDRBS1 2557924 123299 [Transferrin] *induced* an increase in phosphorylation . Positive_regulation TF LRRC7 11466227 839790 The hypothesis tested in this study was that CBP/p300 is required for the synergistic *activation* of the [transferrin] promoter involving PRII and E-box through the formation of a . Positive_regulation TF LTF 24376607 2882138 [Transferrin] level in serum and tumor necrosis factor-a level in CSF decreased , and the levels of iron , transferrin , and prostaglandin E2 in CSF *increased* in PD patients with SD compared with those without SD . Positive_regulation TF MAP3K10 12105200 984547 Furthermore , overexpression of in cultured cells *inhibits* accumulation of labeled [transferrin] in recycling endosomes during receptor mediated endocytosis . Positive_regulation TF MT-CO2 6410138 29438 Binding of aluminum to [transferrin] *requires* and therefore involves a specific iron site . Positive_regulation TF OPN1LW 11466227 839791 The hypothesis tested in this study was that is *required* for the synergistic activation of the [transferrin] promoter involving PRII and E-box through the formation of a ternary complex . Positive_regulation TF PI3 15839893 1398028 We found that markedly *contributes* to the increased surface expression of bovine [transferrin receptor (TfR)] on Theileria infected lymphocytes . Positive_regulation TF PRL 20213525 2249208 Bovine *promotes* the expression of human [transferrin] in the milk of transgenic mice . Positive_regulation TF PRL 22829284 2682287 *promotes* the expression of exogenous human [transferrin] gene in the milk of transgenic mice . Positive_regulation TF PSENEN 16645046 1569570 By using pharmacological gamma-secretase inhibitors or cell lines lacking functional PS/gamma-secretase , here we show that activity is *required* for clearance of [transferrin] from the ERC . Positive_regulation TF RAB4A 18432409 1900174 HRES-1/p28 is a nuclear autoantigen recognized by cross-reactive antiviral antibodies , while *regulates* surface expression of CD4 and the [transferrin receptor (TFR)] through endosome recycling . Positive_regulation TF RBP1 1959859 172582 Serum increased more in the treatment group than it did in the control group , and [transferrin] was *increased* only in the treatment group . Positive_regulation TF RBP2 1959859 172583 Serum increased more in the treatment group than it did in the control group , and [transferrin] was *increased* only in the treatment group . Positive_regulation TF RBP3 1959859 172584 Serum increased more in the treatment group than it did in the control group , and [transferrin] was *increased* only in the treatment group . Positive_regulation TF RBP4 1959859 172585 Serum increased more in the treatment group than it did in the control group , and [transferrin] was *increased* only in the treatment group . Positive_regulation TF RBP5 1959859 172580 Serum increased more in the treatment group than it did in the control group , and [transferrin] was *increased* only in the treatment group . Positive_regulation TF RBP7 1959859 172581 Serum increased more in the treatment group than it did in the control group , and [transferrin] was *increased* only in the treatment group . Positive_regulation TF SETD2 10518614 652435 We investigated whether is *involved* in transcriptional activation of the [transferrin receptor (TfR)] , a membrane protein which mediates cellular iron uptake , in response to iron deprivation . Positive_regulation TF SLCO6A1 21038655 2339073 Comparisons of various parameters between groups showed that TNF-alpha , PDGF expression , MDA content and activity in liver tissue were decreased and GSH content , L-FABP and [transferrin] expression were *increased* significantly at the terminal of the experiment in the YCHD group ( P < 0.05 ) , but only increases of TNF-alpha and GSH were shown in the YGJ group ( P < 0.05 ) . Positive_regulation TF TAPBP 11825486 479940 In condition of serious peritoneal sepsis , can not *increase* albumin , prealbumin , and [transferrin] synthesis alone , whereas rhGH in combination with TPN significantly increase the synthesis of visceral proteins . Positive_regulation TF TAPBP 12455809 1021114 However , multivariate analysis showed that the initial level of transferrin , albumin , total bilirubin and the *induced* level changes in [transferrin] were independent factors significantly correlated with patient survival . Positive_regulation TF TCF4 16425294 1521003 Transient overexpression of protein in cultured Sertoli cells *stimulated* [transferrin] promoter activity , which is a marker of Sertoli cell differentiation . Positive_regulation TF TFCP2 20796026 2318179 Ectopic expression of *led* to increased [transferrin] expression at both the mRNA and protein levels , whereas knockdown of CP2 down-regulated transferrin mRNA and protein expression . Positive_regulation TF TFCP2 20796026 2318180 Moreover , trans *activated* transcription of a [transferrin] reporter gene . Positive_regulation TF TFR2 24639653 2925716 Loss of functional or its binding partner , the original HH protein , *results* in a loss of this [transferrin-sensitivity] . Positive_regulation TF TFRC 10573112 568758 overexpression *enhances* [transferrin] responsiveness and the metastatic growth of a rat mammary adenocarcinoma cell line . Positive_regulation TF TFRC 16904380 1632717 Iron uptake occurs via the internalization of iron loaded [transferrin (Tf)] *mediated* by the interaction with the . Positive_regulation TF TFRC 18347429 1932077 [Transferrin-DNA] complex *mediated* by in combination with interventional trans-arterial injection into a target organ may be a duel-target oriented delivery means to achieve an efficient gene therapy . Positive_regulation TF TGFB1 2725526 113336 *had* no effect on [transferrin] production nor the ability of hormones to influence transferrin production . Positive_regulation TF TNF 3066504 102724 *induced* a rapid increase in the binding of [transferrin] to the cell surface , followed by a return to the basal level within 5 min . Positive_regulation TF TUBB4B 9783905 540765 adrenergic receptors *mediate* cAMP , tissue-type plasminogen activator and [transferrin] production in rat Sertoli cells . Positive_regulation TF XDH 7912169 261943 The effects of a *mediated* free radical generating system containing purine and iron loaded [transferrin] or solutions containing hydrogen peroxide and iron loaded transferrin on substrate utilization and high-energy phosphates were evaluated by nuclear magnetic resonance ( NMR ) spectroscopy in isolated perfused rat hearts . Positive_regulation TFAP2A KLF9 9858544 581958 Transfection studies revealed that is a strong *activator* of [AP-2alpha] promoter activity , whereas cotransfected AP-2alpha resulted in moderate autoactivation of promoter activity . Positive_regulation TFAP2A TNF 10211885 607710 [AP-2] and CREB were not *induced* by . Positive_regulation TFAP2A TNF 11438643 833043 *induced* cleavage of [AP-2alpha] in vivo led to AP-2alpha degradation and loss of DNA binding activity , both of which were prevented by pretreatment with zVEIDfmk . Positive_regulation TFAP2C TP63 18353300 1898431 AP-2 gamma is expressed in skin and previous research suggested a pathway where gene induction *results* in increased expression of [AP-2 gamma] , which in turn is responsible for induction of K14 . Positive_regulation TFCP2 TF 20796026 2318181 Moreover , [CP2] trans *activated* transcription of a reporter gene . Positive_regulation TFF1 FOXA1 10073575 594677 *Activation* of endogenous expression of [TFF1] by and beta gene products was more than 1000 fold in the pancreatic cell line Capan-2 and fivefold in the gastric cell line MKN-45 , whereas the intestinal cell lines HUTU 80 and HT-29 displayed no effect . Positive_regulation TFF1 IL1B 17565651 1753562 , another proinflammatory cytokine , also *up-regulated* [TFF1] expression . Positive_regulation TFF1 TNF 17565651 1753555 *Up-regulation* of [TFF1] ( pS2 ) expression by in gastric epithelial cells . Positive_regulation TFF1 TNF 17565651 1753559 activated NF-kappaB and *up-regulated* endogenous [TFF1] mRNA expression as well as the transcription of the TFF1 reporter genes in a dose dependent manner . Positive_regulation TFF3 TNF 22101519 2514303 Flagellin , IL-13 and all significantly *increased* GAL3ST2 , MUC2 , [TFF3] and TLR5 expression , while only IL-13 increased RETNLB and CHST5 expression . Positive_regulation TFPI ARSA 17259075 1691230 or PIO+ATV+1400 W . alone *had* no effect on myocardial [15-epi-LXA4] . Positive_regulation TFPI ARSA 17259075 1691233 ( 50 mg/kg and 200 mg/kg , but not 10 mg/kg ) *augmented* the LPS effect on [15-epi-LXA4] but attenuated the effect on 6-keto-PGF ( 1alpha ) . Positive_regulation TFPI HBEGF 17274952 1697430 Previously we have shown that insulin-stimulation of RT4 bladder cancer cells leads to increased proliferation , which require HER1 activation , and is accompanied by increased mRNA expression of the EGF-ligands heparin binding EGF-like growth factor ( ) , amphiregulin (AR) , and [epiregulin (EPI)] [ D. Ornskov , E. Nexo , B.S. Sorensen , Insulin induced proliferation of bladder cancer cells is *mediated* through activation of the epidermal growth factor system , FEBS J. 273 ( 2006 ) 5479-5489 ] . Positive_regulation TFPI IL1B 8865534 389036 However , fetal calf serum , phorbol myristate acetate , lipopolysaccharide , and tissue factor did not *stimulate* [TFPI] synthesis . Positive_regulation TFPI PLAT 17672283 1669058 The results showed similar concentrations of TF , TM and PAI-2 in both groups , while increased no significantly and [TFPI] and PAI-1 *increased* significantly in SPE placentas . Positive_regulation TFPI TNF 18690350 1949426 In this study , we investigated the effects of Adp on *induced* expression of TF and [TFPI] in human umbilical vein endothelial cells ( HUVECs ) , and the signaling transduction pathways involved . Positive_regulation TFPI TNF 19169266 2038750 This study further investigated the impact of testosterone on [TFPI] levels in *response* to inflammatory cytokine . Positive_regulation TFPI2 ARF1 24398474 2917567 Mechanistically , *activated* the [TFPI2] promoter in a p53 independent manner that relied upon c-JUN , SP1 , and JNK activity . Positive_regulation TFPI2 ARF3 24398474 2917568 Mechanistically , *activated* the [TFPI2] promoter in a p53 independent manner that relied upon c-JUN , SP1 , and JNK activity . Positive_regulation TFPI2 ARF4 24398474 2917569 Mechanistically , *activated* the [TFPI2] promoter in a p53 independent manner that relied upon c-JUN , SP1 , and JNK activity . Positive_regulation TFPI2 ARF5 24398474 2917570 Mechanistically , *activated* the [TFPI2] promoter in a p53 independent manner that relied upon c-JUN , SP1 , and JNK activity . Positive_regulation TFPI2 ARF6 24398474 2917571 Mechanistically , *activated* the [TFPI2] promoter in a p53 independent manner that relied upon c-JUN , SP1 , and JNK activity . Positive_regulation TFPI2 CA2 20045670 2218282 When phosphatases such as *dependent* protein kinase phosphatase ( CaMKP ) , protein phosphatase 2C ( PP2C ) , protein [phosphatase 5 (PP5)] , and alkaline phosphatase were resolved by polyacrylamide gel electrophoresis in the absence of SDS and the gel was incubated with a fluorogenic substrate such as 4-methylumbelliferyl phosphate ( MUP ) , all of these phosphatase activities could be detected in situ . Positive_regulation TFPI2 CALM3 20045670 2218283 When phosphatases such as *dependent* protein kinase phosphatase ( CaMKP ) , protein phosphatase 2C ( PP2C ) , protein [phosphatase 5 (PP5)] , and alkaline phosphatase were resolved by polyacrylamide gel electrophoresis in the absence of SDS and the gel was incubated with a fluorogenic substrate such as 4-methylumbelliferyl phosphate ( MUP ) , all of these phosphatase activities could be detected in situ . Positive_regulation TFPI2 CAV1 23352616 2747644 We also found that [PP5] activity was elevated about 1.7-fold in the *presence* of 2 µM , and that the scaffolding domain of caveolin-1 is required for this activation . Positive_regulation TFPI2 CD24 21984372 2526006 Over-expression of in A125 cells *resulted* in reduced [TFPI-2] expression and enhanced invasion . Positive_regulation TFPI2 GNA12 12176367 975446 Active forms of and Galpha(13) also *enhance* the arachidonic acid stimulated [PP5] phosphatase activity about 2.5-fold . Positive_regulation TFPI2 GNA13 12176367 975447 Active forms of Galpha(12) and also *enhance* the arachidonic acid stimulated [PP5] phosphatase activity about 2.5-fold . Positive_regulation TFPI2 MED1 14983234 1214613 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED10 14983234 1214608 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED11 14983234 1214611 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED13 14983234 1214595 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED13L 14983234 1214596 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED14 14983234 1214600 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED15 14983234 1214589 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED16 14983234 1214591 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED17 14983234 1214602 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED18 14983234 1214607 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED19 14983234 1214610 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED20 14983234 1214590 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED21 14983234 1214587 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED22 14983234 1214588 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED23 14983234 1214601 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED24 14983234 1214597 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED25 14983234 1214609 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED26 14983234 1214603 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED27 14983234 1214604 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED29 14983234 1214599 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED30 14983234 1214598 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED31 14983234 1214606 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED4 14983234 1214592 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED6 14983234 1214593 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED7 14983234 1214605 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 MED8 14983234 1214594 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 OPA1 14983234 1214612 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Positive_regulation TFPI2 PPP5C 11945080 930054 Subcellular localization of [PP5/TFPI-2] in human placenta : a possible *role* of as an anti-coagulant on the surface of syncytiotrophoblasts . Positive_regulation TFPI2 PTGS2 21515313 2428828 Finally , we ruled out the possibility that [TFPI2] induction by thrombin was *mediated* by , as preincubation with a selective COX-2 inhibitor did not prevent the inductive effect . Positive_regulation TFPI2 RAC1 16549782 1542026 We also propose and test a specific molecular mechanism for [PP5] *stimulation* by . Positive_regulation TFPI2 RAC1 16549782 1542027 [PP5] *stimulation* by provides a unique molecular mechanism for the antagonism of Rho dependent signaling through protein kinases in many cellular processes , including metastasis , immune cell chemotaxis , and neuronal development . Positive_regulation TFPI2 RAC1 19948726 2199049 Consequently , activation of promoted PP5 translocation to the plasma membrane in intact cells and *stimulated* [PP5] phosphatase activity in vitro . Positive_regulation TFPI2 RAC2 16549782 1542028 [PP5] *stimulation* by provides a unique molecular mechanism for the antagonism of Rho dependent signaling through protein kinases in many cellular processes , including metastasis , immune cell chemotaxis , and neuronal development . Positive_regulation TFPI2 RAC3 16549782 1542029 [PP5] *stimulation* by provides a unique molecular mechanism for the antagonism of Rho dependent signaling through protein kinases in many cellular processes , including metastasis , immune cell chemotaxis , and neuronal development . Positive_regulation TFPI2 RPP14 24398474 2917566 Mechanistically , *activated* the [TFPI2] promoter in a p53 independent manner that relied upon c-JUN , SP1 , and JNK activity . Positive_regulation TFPI2 S100A6 24068474 2909992 However , the inhibitory effects of lower concentrations of suramin on *activated* [PP5] are weak and high concentrations of suramin further activated PP5 . Positive_regulation TFPI2 TPR 11969423 933184 Purified [PP5] can , however , be *activated* by partial proteolysis or by the binding of supraphysiological concentrations of polyunsaturated long-chain fatty acids to its domain . Positive_regulation TFPT CDKN1C 11259850 796037 Conversely , [FB(1)] *induced* expression of CDK inhibitors , p21 ( Waf1/Cip1 ) , p27 ( Kip1 ) , and in monkey kidney cells ( CV-1 ) . Positive_regulation TFPT FAS 14596819 1160345 Results indicated that [FB1] can *induce* modulated signaling when TNFalpha is absent . Positive_regulation TFPT IFI27 11259850 796038 Conversely , [FB(1)] *induced* expression of CDK inhibitors , p21 ( Waf1/Cip1 ) , ( Kip1 ) , and p57(Kip2) in monkey kidney cells ( CV-1 ) . Positive_regulation TFPT TNF 12393292 1007900 [FB(1)] *induced* the expression of in the liver of all strains , except the animals with a deleted TNFalpha gene . Positive_regulation TFPT TNF 22761190 2623151 The supernatants were harvested 24 h after the induction and measured for cytokines by using enzyme linked immunosorbent assay . [FB1] *induced* a dose dependent increase in the production of and interleukin-1ß in both AGS and SW742 cell lines . Positive_regulation TFR2 TF 18393371 1899368 Diferric *increased* hepatocyte [Tfr2] protein expression , resulting in a small increase in transferrin but not iron uptake by the Tfr1 independent pathway . Positive_regulation TFR2 TF 18393371 1899369 Diferric *up-regulated* hepatocyte [Tfr2] protein expression but not iron uptake , suggesting that Tfr2 may have a limited role in the Tfr1 independent pathway . Positive_regulation TFR2 TF 19828835 2164811 TFR1 levels are regulated by cellular iron levels while [TFR2] levels are *regulated* by saturation . Positive_regulation TFR2 TF 23556518 2870227 N-linked glycosylation is required for *induced* stabilization of [transferrin receptor 2] , but not for transferrin binding or trafficking to the cell surface . Positive_regulation TFR2 TNF 16221503 1517854 significantly *increased* mRNA levels of [TfR2] and decreased those of DMT1 and IREG1 . Positive_regulation TFR2 TNF 16221503 1517856 *regulates* the mRNA levels of HAMP , IREG1 , DMT1 and [TfR2] in cultured hepatocytes from both iron loaded and control animals . Positive_regulation TFRC IL1B 12767055 1094259 1-40 Beta-amyloid protein fragment modulates the expression of CD44 and [CD71] on the astrocytoma cell line in the *presence* of and TNFalpha . Positive_regulation TFRC MAP2K6 15299023 1303216 This mechanism appears to involve type I PKA dependent phosphorylation of CBP and inhibition of *dependent* phosphorylation of [p90RSK] . Positive_regulation TFRC TF 10762570 683738 The monocytes failed to up-regulate [transferrin receptor] expression appropriately in *response* to . Positive_regulation TFRC TF 10762570 683740 Thus , a nonpermissive state for L. pneumophila intracellular multiplication is associated with low levels of transferrin receptor expression in nonactivated monocytes and with an inability to up-regulate [transferrin receptor] expression in *response* to . Positive_regulation TFRC TF 8450071 214127 We have found that iron markedly *upregulates* both [transferrin receptor] expression and intracellular ferritin content in both nonactivated ( 2.3- and 1.3-fold , respectively ) and IFN gamma activated ( 3.4- and 2.9-fold , respectively ) monocytes . Positive_regulation TFRC TNF 12767055 1094258 1-40 Beta-amyloid protein fragment modulates the expression of CD44 and [CD71] on the astrocytoma cell line in the *presence* of IL1beta and . Positive_regulation TFRC TNF 15614194 1387623 We analyzed reactive oxygen intermediate ( ROI ) production by peripheral blood granulocytes , the production of IL-2 , IL-5 , IL-10 , IL-12 , and cytokines by lymphocytes , and the *activation* of CD25 , CD26 , CD69 , [CD71] , and HLA DR antigen expression . Positive_regulation TFRC TNF 16224057 1483561 *caused* upregulation of [TfR] and DMT1 and downregulation of FP1 , which were demonstrated in mRNA as well as protein levels . Positive_regulation TFRC TNF 1921451 168510 *induced* expression of CD4 and [CD71] , increased the intensity of HLA-DR , CD25 , CD11c and CD13 expression and decreased both the intensity and frequency of sIg and cIg positivity . Positive_regulation TFRC TNF 1921451 168516 alpha-IFN decreased CD25 expression , the tartrate-resistant acid phosphatase activity ( TRAP ) , reduced the *induced* CD4 and [CD71] expression and antagonized the TNF effect on the Ig expression . Positive_regulation TFRC TNF 2016326 156935 and interleukin 1-alpha *regulate* [transferrin receptor] in human diploid fibroblasts . Positive_regulation TFRC TNF 2016326 156939 We have studied [transferrin receptor] expression in MRC5 human fibroblasts in *response* to ( TNF , cachectin ) or interleukin 1-alpha (IL-1) . Positive_regulation TFRC TNF 2016326 156943 Under these conditions , stimulation of [ 3H ] thymidine incorporation was minimal , suggesting that the *induction* of [transferrin receptor] by and IL-1 is mediated by a growth independent regulatory mechanism . Positive_regulation TFRC TNF 21705614 2465724 Furthermore , luteolin inhibited *induced* phosphorylation of mitogen activated protein kinase/extracellular signal regulated kinase ( ERK ) kinase [1/ERK/p90] ( RSK ) , mitogen activated protein kinase kinase 4/c-Jun N-terminal kinase/c-Jun , and Akt/p70 ( S6K ) . Positive_regulation TFRC TNF 9726030 529708 The fall in sTfR levels may reflect an impaired erythroid growth and/or [TfR] expression *mediated* by and IFN-gamma . Positive_regulation TG TNF 12404274 1009777 also *induced* increased [thyroglobulin] secretion and reduced VEGF secretion by anaplastic tumor cells . Positive_regulation TGFA EDN2 22407503 2624373 [Transforming growth factor-alpha] *induces* receptor A expression in osteoarthritis . Positive_regulation TGFA HBEGF 9796995 543503 When added to the medium , [transforming growth factor-alpha] , basic fibroblast growth factor , or HB-EGF rapidly *induced* mRNA expression . Positive_regulation TGFA IL1B 15474551 1319079 Gastrin and *stimulated* the secretion of heparin binding epidermal growth factor and amphiregulin but not [transforming growth factor-alpha] from parietal cells . Positive_regulation TGFA IL1B 16847181 1588119 The messenger RNA expressions of LARC ( liver and activation regulated chemokine ) , GMCSF ( granulocyte-macrophage colony stimulating factor ) , epiregulin , ICAM1 ( intercellular adhesion molecule 1 ) , and [TGFA] ( transforming growth factor alpha ) were more strongly *up-regulated* by IL-1alpha and/or in MECF than in SF , suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles . Positive_regulation TGFA TNF 10623834 658415 *regulates* [transforming growth factor-alpha] expression in regenerating murine liver and isolated hepatocytes . Positive_regulation TGFA TNF 19441104 2101421 D10 supplementation did not suppress activation of hepatocyte growth factor (HGF) , *induction* of [transforming growth factor alpha] ( TGF-alpha ) expression , or alpha-interleukin-6 cytokine signaling , p42/44 extracellular signal regulated kinase ( ERK ) activation , immediate early gene expression , or expression of CCAAT/enhancer binding protein beta ( C/EBPbeta ) , but did augment expression of the mito-inhibitory factors C/EBPalpha , p21 ( Waf1/Cip1 ) , and p27 ( Kip1 ) . Positive_regulation TGFB1 ADRB2 11720783 883987 stimulation *enhances* latent transforming growth factor-beta binding protein-1 and [transforming growth factor-beta1] expression in rat hippocampus after transient forebrain ischemia . Positive_regulation TGFB1 AGR2 15578192 1375091 *stimulates* [transforming growth factor-beta1] ( TGF-beta1 ) and acts as a potent stimulant of myocyte growth and fetal contractile protein gene transcription . Positive_regulation TGFB1 ALOX5 16750418 1590045 1,25-Dihydroxyvitamin D ( 3 ) ( 1,25 ( OH ) ( 2 ) D ( 3 ) ) and [transforming growth factor beta] ( TGFbeta ) potently *induce* <5-lipoxygenase (5-LO)> in myeloid cells . Positive_regulation TGFB1 ALOX5 16849505 1588485 Lastly , mechanistic insights are provided by demonstrating that IL-13 induced <5-LO> activation is *required* for optimal stimulation and activation of [TGF-beta(1)] and the inhibition of matrix metalloproteinase-12 . Positive_regulation TGFB1 ARSA 21584653 2531913 Moreover , *increased* the production of the anti-inflammatory cytokines [transforming growth factor beta-1] and interleukin-10 in neuron-glia cultures after stimulation with LPS . Positive_regulation TGFB1 CAPN8 9428805 481956 Cell associated *activation* of latent [transforming growth factor-beta] by . Positive_regulation TGFB1 CD14 10768925 685055 In this study , we investigated whether [TGF-beta1] inhibition of LPS induced expression of inflammatory cytokines in the septic shock *results* from downregulation of LPS stimulated expression of , an LPS receptor . Positive_regulation TGFB1 CD14 10768925 685059 Thus , our results suggest that [TGF-beta1] inhibition of LPS stimulated inflammatory responses *resulted* from downregulation of and also may be a possible mechanism of TGF-beta1 inhibition of LPS induced septic shock . Positive_regulation TGFB1 CLU 10406964 629664 [Transforming growth factor-beta] ( TGFbeta ) *induces* gene expression of the glycoprotein in a variety of cell types via a consensus AP-1 binding site . Positive_regulation TGFB1 CLU 19296674 2086861 Down regulated proteins were predominantly involved with cell-cell contact and cell-matrix adhesion ( e.g. , desmocollin 2 , , collagen XVII and [transforming growth factor-beta] *induced* protein ig-h3 ) , while up-regulated proteins were proteases and factors that promote migration ( MMP-1 , kallikrein 6 , TIMP-1 , and S100A4/metastasin ) . Positive_regulation TGFB1 CST6 17429295 1724083 Therefore , the *role* of in the pathogenesis of coronary artery ectasia and its potential interaction with [transforming growth factor-beta1] should be evaluated in further studies . Positive_regulation TGFB1 CTGF 15037576 1224042 In the presence of mechanical stress , is *necessary* for [TGF-beta1-stimulation] of myofibroblast differentiation and subsequent collagen matrix contraction , but CTGF alone is not sufficient to induce myofibroblast differentiation and collagen matrix contraction . Positive_regulation TGFB1 CTGF 15536170 1374837 [TGF-beta(1)] *induced* a greater increase in fibronectin and collagen IV secretion in both PTC ( P < 0.01 ) and CF ( P < 0.01 ) compared with that observed with alone . Positive_regulation TGFB1 CTGF 15862293 1400928 is *induced* by [transforming growth factor-beta] ( TGF-beta ) via Smad activation in mesangial cells . Positive_regulation TGFB1 CTGF 16046020 1447724 The aim of the present work was to investigate the balance between Smad and Rho signalling pathways in the [TGF-beta1] *induction* and modulation of radiation induced fibrogenic differentiation after addition of pravastatin , an inhibitor of Rho isoprenylation . Positive_regulation TGFB1 CTGF 16484225 1548581 is *induced* by [transforming growth factor-beta] ( TGFbeta ) in fibroblasts and is overexpressed in connective tissue disease . Positive_regulation TGFB1 CTGF 17393107 1716265 The results showed that [TGF-beta1] could *induce* tubular and PAI-1 mRNA expression . Positive_regulation TGFB1 CTGF 18201696 1870322 In vitro , [transforming growth factor-beta] ( TGF-beta ) *induces* expression in mesenchymal cells . Positive_regulation TGFB1 CTGF 18314002 1897488 In osteoblasts , is *induced* by [TGF-beta1] where it acts as a downstream mediator of TGF-beta1 induced matrix production . Positive_regulation TGFB1 CTGF 18535390 1958880 expression is *induced* by [TGF-beta(1)] in several cell types and CTGF mediates several of the downstream actions of TGF-beta(1) . Positive_regulation TGFB1 CTGF 19565505 2104335 is *induced* by [transforming growth factor beta] ( TGFbeta ) and is a mediator of some profibrotic effects of TGFbeta in vitro . Positive_regulation TGFB1 CTGF 20393108 2319801 is *induced* by [transforming growth factor-beta] ( TGF-ß ) after corneal wounding . Positive_regulation TGFB1 CTGF 9925376 559369 , a 36- to 38-kDa peptide , is selectively *induced* by [transforming growth factor-beta] and has been suggested to contribute to tissue repair . Positive_regulation TGFB1 EDN2 11040336 742064 *stimulates* [transforming growth factor-beta1] and collagen synthesis in stellate cells from control but not cirrhotic rat liver . Positive_regulation TGFB1 EDN2 17379848 1748414 Endothelin-1 induces alveolar epithelial-mesenchymal transition through type A receptor *mediated* production of [TGF-beta1] . Positive_regulation TGFB1 EPHB2 10406835 629633 Thus , we show that , through AP-1 activation , is *involved* in Ang II-induced [TGF-beta(1)] mRNA expression in VSMCs and suggest that ERK may participate in vascular remodeling of hypertension . Positive_regulation TGFB1 EPHB2 12677169 1076920 Glycated albumin increases oxidative stress , activates NF-kappa B and extracellular signal regulated kinase ( ERK ) , and stimulates *dependent* [transforming growth factor-beta 1] production in macrophage RAW cells . Positive_regulation TGFB1 EPHB2 12677169 1076924 We demonstrate , for the first time , that glycated albumin activates RAW cell ERK and promotes *dependent* increases in [TGF-beta(1)] production , oxidative stress , and NF-kappa B activation . Positive_regulation TGFB1 EPHB2 12824291 1113602 In a heterologous DNA binding transcription assay , biochemical or dominant negative blockade *reduced* [TGF-beta1] induced Smad3 activity . Positive_regulation TGFB1 EPHB2 14630909 1201101 Expression of functional Schistosoma mansoni Smad4 : role in *mediated* [transforming growth factor beta] ( TGF-beta ) down-regulation . Positive_regulation TGFB1 EPHB2 15389548 1304761 Like NFLC , induction of urokinase plasminogen activator (uPAR) , transin/matrix metalloproteinase 3 (MMP3) , Fra-1 and [transforming growth factor beta 1] ( TGF beta 1 ) *required* collaborative and JNK signaling while the increased expression of cortexin , rat collapsin response mediator protein 4 ( rCRMP4 ) , rat growth and transformation dependent protein ( RGT ) , and synapsin II required neither mitogen activated protein kinase (MAPK) pathway . Positive_regulation TGFB1 EPHB2 15979845 1497974 Using pharmacological inhibitors specific for MAP kinase family members , we found that , but not JNK or p38 , is *required* for [TGF-beta1] induction of p21WAF1/Cip1 . Positive_regulation TGFB1 EPHB2 16972260 1627987 Taken together our results demonstrate that Hcy mediated [TGF-beta1] upregulation triggers endothelial-myofibroblast differentiation secondary to FAK phosphorylation and that Hcy induced activation is *involved* in ECM remodeling by altering collagen type-1 homeostasis . Positive_regulation TGFB1 EPHB2 17335076 1712159 Induction of [transforming growth factor-beta1] by basic fibroblast growth factor in rat C6 glioma cells and astrocytes is *mediated* by signaling and AP-1 activation . Positive_regulation TGFB1 EPHB2 17396111 1760656 An kinase inhibitor significantly *reduced* the renin induced ERK1/2 phosphorylation and the subsequent increase in [transforming growth factor-beta1] ( TGF-beta1 ) and plasminogen activator inhibitor-1 mRNA expression . Positive_regulation TGFB1 EPHB2 17468136 1766526 The mitogenic activity of [TGF-beta1] on ASM cells was *inhibited* by selective inhibitors of TGF-beta receptor I kinase ( SD-208 ) , phosphatidylinositol 3-kinase ( PI3K , LY-294002 ) , ( PD-98059 ) , JNK ( SP-600125 ) , and NF-kappaB ( AS-602868 ) . Positive_regulation TGFB1 EPHB2 17481939 1750526 In a previous study , we reported that SPC induces differentiation of human adipose tissue derived mesenchymal stem cells ( hATSCs ) to smooth muscle-like cell types through *dependent* autocrine secretion of [TGF-beta1] and delayed activation of the TGF-beta1-Smad pathway . Positive_regulation TGFB1 EPHB2 18161870 1918907 Taken together , these results suggest that the osteoblast derived [TGF-beta1] *acts* through Akt and , which in turn activates IKKalpha/beta and NF-kappaB , resulting in the activations of beta1 and beta3 integrins and contributing the migration of breast cancer cell . Positive_regulation TGFB1 EPHB2 20483351 2288604 CS *inhibited* S100b induced [TGF-beta1] and fibronectin expression in mouse mesangial cells by suppressing activation of Smad2/3 , extracellular signal regulated kinase ( ) /mitogen activated protein kinase (MAPK) , and oxidative stress . Positive_regulation TGFB1 FAS 10924745 718406 Flow cytometric analyses demonstrated that [TGF-beta1] , IL-1beta , and EGF did not *induce* expression on the cell surface . Positive_regulation TGFB1 FAS 19268879 2055621 *increased* the level of [TGF-beta1] , Smad-3 , and p21 protein in ovarian cancer cells known to be more sensitive to their inhibitory effect . Positive_regulation TGFB1 IFI27 10942583 722587 We show here that [transforming growth factor-beta] *induces* the accumulation of a form of ( Kip1 ) representing a subpopulation of total p27 ( Kip1 ) in growth arrested Mv1Lu epithelial cells . Positive_regulation TGFB1 IGFBP1 11934254 927767 [Transforming growth factor beta] ( TGF-beta ) , decorin ( a proteoglycan in the ECM ) , and melanoma cell adhesion molecule ( Mel-CAM ) inhibit , and insulin-like growth factor II (IGF-II) , , and endothelin 1 (ET-1) *stimulate* EVT cell migration/invasion . Positive_regulation TGFB1 IGFBP1 9356040 461773 Both human and rat mesangial cells grown on BSA-AGE showed increased IGF-I and total and bioactive TGF-beta medium levels and *enhanced* IGF-I , IGF-II , and [TGF-beta1] gene expression , compared with cells grown on BSA , whereas total and IGFBP-3 medium content , IGF receptor density and affinity , and IGF-I receptor transcripts were unchanged . Positive_regulation TGFB1 IL1B 10433158 633932 Stimulation with ( 1 ng/mL ) or TNFalpha ( 1 ng/mL ) *resulted* in a significant increase in [TGFbeta1] mRNA expression after 48 hours : 2.7 and 2.1 times the control level , respectively . Positive_regulation TGFB1 IL1B 10433158 633934 However , TNFalpha induced increase in TGFbeta1 mRNA expression was not translated intoTGFbeta1 protein secretion , while stimulation *induced* a significant increase in TGFbeta1 protein secretion as well as [TGFbeta1] mRNA expression . Positive_regulation TGFB1 IL1B 12115740 964349 Freshly isolated chondrocytes , dedifferentiated chondrocytes , and synoviocytes were treated with IL-4 before determination of nitric oxide ( NO ) and collagenase production in response to IL-1beta , or before proliferation assays in *presence* of , platelet derived growth factor ( PDGF ) , or [transforming growth factor (TGF)-beta] . Positive_regulation TGFB1 IL1B 12200971 982984 The effect of IL-1 beta on syndecan-1 mRNA synthesis was partially reversed after adding PDGF-BB and [TGF-beta 1] , separately or in combination , in the *presence* of . Positive_regulation TGFB1 IL1B 12794825 1098359 Mediation of *induced* [transforming growth factor beta1] expression by activator protein 4 transcription factor in primary cultures of bovine articular chondrocytes : possible cooperation with activator protein 1 . Positive_regulation TGFB1 IL1B 12794825 1098364 *induces* an increase of [TGFbeta1] in articular chondrocytes through activation of AP-4 and AP-1 binding to the TGFbeta1 gene promoter . Positive_regulation TGFB1 IL1B 15529381 1335751 *Stimulation* of [TGFbeta1] expression by was observed only in normal atmospheric conditions . Positive_regulation TGFB1 IL1B 16253647 1471881 The question of whether tumor necrosis factor alpha (TNF-alpha) and/or *regulate* the release of [TGF-beta1] was investigated by incubation of adipose tissue explants with a soluble human TNF-alpha receptor ( etanercept ) and a neutralizing antihuman IL-1 beta antibody . Positive_regulation TGFB1 IL1B 16365456 1505027 NF-kappaB and activator protein 1 response elements and the role of histone modifications in *induced* [TGF-beta1] gene transcription . Positive_regulation TGFB1 IL1B 16421162 1547528 Diltiazem suppresses collagen synthesis and *induced* [TGF-beta1] production on human peritoneal mesothelial cells . Positive_regulation TGFB1 IL1B 16421162 1547529 The objectives of this study were to examine the effects of diltiazem on collagen- and *induced* [TGF-beta1] production on human PMCs and the signalling pathway of diltiazem in this induction . Positive_regulation TGFB1 IL1B 16421162 1547530 Diltiazem suppressed collagen synthesis of human PMCs and inhibited *induced* [TGF-beta1] production on human PMCs . Positive_regulation TGFB1 IL1B 16805677 1579604 In this study , we investigated the in vitro effect of avocado and soya unsaponifiables ( ASU ) on the expression of [TGF-beta1] , TGF-beta2 , and bone morphogenetic protein-2 (BMP-2) by human periodontal ligament (HPL) and human alveolar bone ( HAB ) cells in the *presence* of . Positive_regulation TGFB1 IL1B 17013806 1666346 RT-PCR analyses showed that TNF-alpha and *increased* the mRNA levels of both [TGF-beta1] and TGF-beta2 . Positive_regulation TGFB1 IL1B 17013806 1666350 IFN-gamma enhanced constitutively expressed , as well as , TNF-alpha-and *induced* [TGF-beta1] mRNA levels but decreased TGF-beta2 mRNA . Positive_regulation TGFB1 IL1B 17763417 1801840 TGFbetaRII overexpression abolished the loss of [TGFbeta1] responsiveness *induced* by . Positive_regulation TGFB1 IL1B 18276918 1891287 The results of in vitro studies indicated that *caused* the activation of [transforming growth factor-beta] via RhoA/alphavbeta6 integrin dependent mechanisms and the inhibition of the alphavbeta6 integrin and/or transforming growth factor-beta signaling completely blocked the IL-1beta mediated protein permeability across alveolar epithelial cell monolayers . Positive_regulation TGFB1 IL1B 19134459 2025398 Compared with the blank control group , might induce TEMT , which was showed in increasing expression of alpha-SMA , increasing secreting of FN and decreasing expression of E-cadherin , and at the same time the expressions of [TGF-beta1] and ILK were *enhanced* ( P < 0.05 ) . Positive_regulation TGFB1 IL1B 19420104 2120144 *regulates* proximal tubular cell [transforming growth factor beta-1] signalling . Positive_regulation TGFB1 IL1B 19857272 2160548 [TGF-beta1] induced epithelial to mesenchymal transition ( EMT ) in human bronchial epithelial cells is *enhanced* by but not abrogated by corticosteroids . Positive_regulation TGFB1 IL1B 2009947 154929 Neither nor IL-6 *had* an observable effect on [TGF beta 1] mRNA expression . Positive_regulation TGFB1 IL1B 22859271 2687431 Reciprocally , secreted by OSCC cells , *stimulated* [transforming growth factor beta 1] secretion from stromal fibroblasts to induce PDPN expression in OSCC cells . Positive_regulation TGFB1 IL1B 7980594 281359 *induces* transforming growth factor-beta , ( [TGF-beta 1] ) production by rat aortic smooth muscle cells . Positive_regulation TGFB1 IL1B 7980594 281365 In cultured rat aortic smooth muscle cells ( RASMCs ) *induced* [TGF-beta 1] mRNA expression , which was concentration ( 10 pM-10 nM ) - and time ( 2-48 h ) -dependent , and sensitive to cycloheximide . Positive_regulation TGFB1 IL1B 7980594 281366 Our data demonstrate for the first time that is a potent *inducer* of [TGF-beta 1] synthesis and release in vascular smooth muscle cells . Positive_regulation TGFB1 IL1B 8623935 354871 Stimulation of HPMCs with *increased* steady-state levels of [TGF-beta 1-] and TGF-beta 2-specific mRNA . Positive_regulation TGFB1 IL1B 8914021 395661 *Stimulation* of [TGF-beta 1] synthesis by in D-glucose primed cells was inhibited by cycloheximide but not by actinomycin-D . Positive_regulation TGFB1 IL1B 8914021 395662 These results demonstrate that the interaction of D-glucose and *lead* to secretion of [TGF-beta 1] by HPTC . Positive_regulation TGFB1 ITGB2 17477023 1738584 In addition , direct interaction between monocyte-macrophage and PTC cell surface ICAM-1 *stimulates* [TGF-beta1] synthesis . Positive_regulation TGFB1 JAG1 12039979 949574 [Transforming growth factor-beta] *induces* renal epithelial expression in fibrotic disease . Positive_regulation TGFB1 JAG1 20169621 2242613 [TGFbeta1] *induces* expression in astrocytes via ALK5 and Smad3 and regulates the balance between oligodendrocyte progenitor proliferation and differentiation . Positive_regulation TGFB1 MAP2K6 10511312 651218 Ras- and *dependent* and -independent pathways in p21Cip1/Waf1 induction by fibroblast growth factor-2 , platelet derived growth factor , and [transforming growth factor-beta1] . Positive_regulation TGFB1 MAP2K6 17335076 1712167 Induction of [transforming growth factor-beta1] by basic fibroblast growth factor in rat C6 glioma cells and astrocytes is *mediated* by signaling and AP-1 activation . Positive_regulation TGFB1 MAP2K6 9038360 415475 [Transforming growth factor-beta1] *induces* activation of Ras , Raf-1 , and MAPK in rat hepatic stellate cells . Positive_regulation TGFB1 MAP2K6 9038360 415515 In this paper we show that in cultured hepatic stellate cells [TGF-beta1] *induces* activation of Ras , Raf-1 , and MAPK p42 and p44 . Positive_regulation TGFB1 MMP28 16640888 1553000 Ovarian carcinoma cells activate HPMC through [TGF-beta1] , which *induces* higher expressions of of ovarian carcinoma cells . Positive_regulation TGFB1 MMP28 18505915 1917794 When cancer cells were cultured on plastic , [TGF-beta1] , TGF-beta2 , and TGF-beta3 *induced* secretion , loss of cell-cell junctions , down-regulation of E-cadherin , up-regulation of N-cadherin , and acquisition of a fibroblastoid phenotype , consistent with an epithelial-to-mesenchymal transition . Positive_regulation TGFB1 MMP7 16640888 1553015 Ovarian carcinoma cells activate HPMC through [TGF-beta1] , which *induces* higher expressions of of ovarian carcinoma cells . Positive_regulation TGFB1 MMP7 18505915 1917810 When cancer cells were cultured on plastic , [TGF-beta1] , TGF-beta2 , and TGF-beta3 *induced* secretion , loss of cell-cell junctions , down-regulation of E-cadherin , up-regulation of N-cadherin , and acquisition of a fibroblastoid phenotype , consistent with an epithelial-to-mesenchymal transition . Positive_regulation TGFB1 PECAM1 7930623 274764 Analysis of the intracellular signaling pathways indicates that [TGF-beta 1] *induces* protein kinase C activity , as well as phosphorylation and association with cytoskeletal components . Positive_regulation TGFB1 PLAT 10541321 563420 Intraventricular recombinant was *followed* by a rise in CSF [TGF-beta1] ( p = 0.0007 ) . Positive_regulation TGFB1 PLAT 9875232 557168 Plasmin , substilisin-like endoproteases , , and urokinase plasminogen activator are *involved* in activation of latent [TGF-beta 1] in human seminal plasma . Positive_regulation TGFB1 PLAU 10652434 663183 [TGF-beta1] *induces* and PAI-1 secretion and promotes binding of uPA at the external plasma membrane with increased membrane associated plasmin activity . Positive_regulation TGFB1 PLAU 15452360 1354472 The aim of this study was to determine whether [transforming growth factor-beta1] ( TGF-beta1 ) *induces* the synthesis , release and gene expression of ( uPA ) in hepatic stellate cells . Positive_regulation TGFB1 PLAU 16554301 1562036 2 ) activation of plasminogen by and subsequent *activation* of [transforming growth factor-beta1] ( TGF-beta1 ) and matrix metalloproteinase (MMP)-2 and -9 by plasmin are critical pathways through which uPA expressing macrophages accumulate in the heart and cause fibrosis ; Positive_regulation TGFB1 PLAU 8126064 251290 The *role* of receptor bound ( uPA ) in cellular activation of latent [transforming growth factor-beta] ( LTGF-beta ) was investigated in a model system of mouse LB6 cells transfected with either a human uPA receptor cDNA ( LhuPAR+ ) , a human prouPA cDNA ( LhuPA ) , or a control neomycin-resistance cDNA ( Lneo ) . Positive_regulation TGFB1 PLAU 9875232 557169 Plasmin , substilisin-like endoproteases , tissue plasminogen activator , and are *involved* in activation of latent [TGF-beta 1] in human seminal plasma . Positive_regulation TGFB1 S100B 17321517 1719795 The present study demonstrates that high glucose- or *induced* [TGF-beta1] and fibronectin expression , but this increased expression is inhibited by magnolol via the ERK/MAPK/Akt signaling pathway in human RPE cells . Positive_regulation TGFB1 S100B 19666101 2132704 KIOM-79 prevents *induced* [TGF-beta1] and fibronectin expression in mouse mesangial cells . Positive_regulation TGFB1 S100B 19666101 2132706 The effect of KIOM-79 on *induced* [TGF-beta1] and fibronectin expression was investigated using RT-PCR , ELISA , and Western blot on mesangial cells . Positive_regulation TGFB1 S100B 19666101 2132708 *induced* an increase in the expression [TGF-beta1] and fibronectin . Positive_regulation TGFB1 S100B 20483351 2288601 Extract of Cassiae Semen and its major compound inhibit *induced* [TGF-beta1] and fibronectin expression in mouse glomerular mesangial cells . Positive_regulation TGFB1 S100B 20483351 2288603 CS inhibited *induced* [TGF-beta1] and fibronectin expression in mouse mesangial cells by suppressing activation of Smad2/3 , extracellular signal regulated kinase ( ERK ) /mitogen activated protein kinase (MAPK) , and oxidative stress . Positive_regulation TGFB1 SARM1 15934312 1414668 Both and Smad3 *mediate* [TGFbeta1] signaling as downstream mediators in MSCs . Positive_regulation TGFB1 SPHK1 15485866 1347359 is *induced* by [transforming growth factor-beta] and mediates TIMP-1 up-regulation . Positive_regulation TGFB1 STAT4 15879087 1406001 Conversely , enforced expression of partly prevented TGF-beta1 's inhibition of IFN-gamma expression during priming , but did not *prevent* [TGF-beta1] 's inhibition of Th1 development . Positive_regulation TGFB1 STAT4 17404271 1721929 We further show that is partially *required* for the development of IL-23- , but not [TGFbeta1] plus IL-6 primed IL-17 secreting cells , and is absolutely required for IL-17 production in response to IL-23 plus IL-18 . Positive_regulation TGFB1 SYNM 18637143 1960102 The upregulated hepatic protein expression of [transforming growth factor-beta] ( TGF-beta ) in *response* to was markedly attenuated by HGF gene transfer accompanied by the increased protein expression for matrix metalloproteinases (MMP)-3 and -13 . Positive_regulation TGFB1 TGM2 10926856 719200 This small effect was not specific for TSP-1 : matrix metalloproteinase 2 , tissue inhibitor of matrix metalloproteinase 2 and active plasminogen activator inhibitor 1 , but not , human serum albumin or immunoglobulin , *had* quantitatively similar effects on latent [TGF-beta1] . Positive_regulation TGFB1 TGM2 12763041 1093828 We have investigated the novel function of intracellular reactive oxygen species ( ROS ) in the *activation* of in situ by lysophosphatidic acid (LPA) and [transforming growth factor-beta] ( TGF-beta ) in Swiss 3T3 fibroblasts . Positive_regulation TGFB1 TGM2 12810961 1102870 The lack of *prevented* the production of active [transforming growth factor-beta1] in macrophages exposed to apoptotic cells , which is required for the up-regulation of TGase2 in the thymus in vivo , for accelerating deletion of CD4+CD8+ cells and for efficient phagocytosis of apoptotic bodies . Positive_regulation TGFB1 TGM2 1972706 135388 however , [TGF-beta 1] did not *induce* any significant change in activity in the carcinoma derived cell lines SCC-13 , SCC-15 , and SQCC/Y1 . Positive_regulation TGFB1 TGM2 7896898 299979 The activation of latent [transforming growth factor-beta] ( TGF-beta ) by vascular endothelial cells ( ECs ) is *regulated* by cellular plasminogen activator (PA)/plasmin , , and latent TGF-beta levels . Positive_regulation TGFB1 TLR7 22968409 2673472 The results demonstrated that chicken CD4+ and CD8+ T-cells express and that the various isolates of lactobacilli differentially *induces* the expression of interleukin 10 , interferon-gamma and [transforming growth factor beta] . Positive_regulation TGFB1 TNF 10433158 633931 Stimulation with IL-1beta ( 1 ng/mL ) or ( 1 ng/mL ) *resulted* in a significant increase in [TGFbeta1] mRNA expression after 48 hours : 2.7 and 2.1 times the control level , respectively . Positive_regulation TGFB1 TNF 10433158 633933 However , *induced* increase in [TGFbeta1] mRNA expression was not translated intoTGFbeta1 protein secretion , while IL-1beta stimulation induced a significant increase in TGFbeta1 protein secretion as well as TGFbeta1 mRNA expression . Positive_regulation TGFB1 TNF 11216681 785856 Exogenous also *enhanced* the release of interleukin-6 ( p < 0.01 ) and [transforming growth factor-beta1] ( p < 0.05 ) , whereas the secretion of transforming growth factor-beta1 was increased by insulin-like growth factor-I and prostaglandin E2 as well . Positive_regulation TGFB1 TNF 11502094 847436 TNF-alpha , PDGF , and TGF-beta(1) expression by primary mouse bronchiolar-alveolar epithelial and mesenchymal cells : *induces* [TGF-beta(1)] . Positive_regulation TGFB1 TNF 12901826 1118847 The secretion of by HMPC increased after incubation with 100 mg/L erythromycin for 3 or 5 days , and the secretion of [TGF-beta(1)] *increased* markedly after incubation with lower or higher concentrations of erythromycin . Positive_regulation TGFB1 TNF 15574511 1355715 stimulation alone did not *increase* [TGF-beta1] synthesis . Positive_regulation TGFB1 TNF 15653932 1381615 *induces* [transforming growth factor-beta1] expression in lung fibroblasts through the extracellular signal regulated kinase pathway . Positive_regulation TGFB1 TNF 15653932 1381617 We recently reported that *upregulates* [TGF-beta(1)] expression in primary mouse lung fibroblasts ( MLFs ) , a key cell population in fibrogenesis . Positive_regulation TGFB1 TNF 16249231 1553515 The immunohistological findings of a limited sample suggest a *role* for BM in sacroiliitis , for and IL6 in early , active lesions , and for [TGFbeta1] at the time of secondary cartilage and bone proliferation . Positive_regulation TGFB1 TNF 16253647 1471880 The question of whether and/or interleukin 1 beta (IL-1 beta) *regulate* the release of [TGF-beta1] was investigated by incubation of adipose tissue explants with a soluble human TNF-alpha receptor ( etanercept ) and a neutralizing antihuman IL-1 beta antibody . Positive_regulation TGFB1 TNF 17013806 1666345 RT-PCR analyses showed that and IL-1beta *increased* the mRNA levels of both [TGF-beta1] and TGF-beta2 . Positive_regulation TGFB1 TNF 17173255 1662382 Since and IL-10 are involved in regulation of inflammation , and [TGF-beta 1] can *induce* fibrosis and renal insufficiency - dominant features of end-stage renal disease ( ESRD ) , we explored the hypothesis that polymorphisms of these cytokine genes may be possible genetic susceptibility factors for the progression of renal failure . Positive_regulation TGFB1 TNF 18569384 1929872 The latent form of [TGFbeta(1)] is *induced* by through an ERK specific pathway and is activated by asbestos derived reactive oxygen species in vitro and in vivo . Positive_regulation TGFB1 TNF 18569384 1929874 The mechanism of *induction* of [TGFbeta(1)] expression appears to be complex , involving both transcriptional and post-transcriptional mechanisms . Positive_regulation TGFB1 TNF 18720042 1961609 We were able to show that IFN-gamma , [TGF-beta(1)] and all *increased* the binding activity of transcription factor AP-1 ( AP-1 ) . Positive_regulation TGFB1 TNF 20141610 2178965 *induces* [TGF-beta1] expression in lung fibroblasts at the transcriptional level via AP-1 activation . Positive_regulation TGFB1 TNF 20458271 2268641 Here , we showed that in cultures of HK-2 cells , [TGF-beta1] expression was *up-regulated* by . Positive_regulation TGFB1 TNF 20458271 2268642 Expression of [TGF-beta1] in TECs , potentially *induced* by proinflammatory , renders TECs resistance to cell death . Positive_regulation TGFB1 TNF 23171464 2700393 ( iv ) decreased secretion of , IL-12 , interferon-? and IL-2 and ( v ) but *up-regulated* IL-4 and [transforming growth factor beta] ( TGF-ß ) in the lymph nodes . Positive_regulation TGFB1 TNF 7586747 333776 *mediates* the release of bioactive [transforming growth factor-beta] in murine microglial cell cultures . Positive_regulation TGFB1 TNF 7900924 300115 *induction* of [transforming growth factor-beta 1] ( TGF-beta 1 ) in rat endothelial cells suggested that TGF-beta , a known mediator of inflammatory effects of TNF-alpha , may be involved in the sensitivity of aged thyroid cells to TNF-alpha ( G. Chen , A. E. Pekary , and J. M. Hershman . Positive_regulation TGFB1 TNF 7900924 300116 In aged cells *increased* their [TGF-beta 1] ( and -beta 2 and -beta 3 ) mRNA levels 5.4-fold ( and > 10-fold ) , respectively , while in young cells all TGF-beta mRNAs remained almost undetectable during incubation with TNF-alpha . Positive_regulation TGFB1 TNF 9186079 436763 Exposure to VLDL , IDL , LDL , or a high concentration of HDL *enhanced* the secretion of interleukin-6 , platelet derived growth factor , and [transforming growth factor-beta] by mesangial cells , whereas secretion was stimulated by oxidized LDL . Positive_regulation TGFB1 TNF 9802563 544017 In addition , [TGF-beta1] also acted directly on the intermediate stage of DC to prevent their over-maturation , which results in a preferential decrease in MHC class II , but not in CD86 , in the *presence* of . Positive_regulation TGFB2 ALOX5 16750418 1590046 1,25-Dihydroxyvitamin D ( 3 ) ( 1,25 ( OH ) ( 2 ) D ( 3 ) ) and [transforming growth factor beta] ( TGFbeta ) potently *induce* <5-lipoxygenase (5-LO)> in myeloid cells . Positive_regulation TGFB2 CAPN8 9428805 481970 Cell associated *activation* of latent [transforming growth factor-beta] by . Positive_regulation TGFB2 CLU 10406964 629665 [Transforming growth factor-beta] ( TGFbeta ) *induces* gene expression of the glycoprotein in a variety of cell types via a consensus AP-1 binding site . Positive_regulation TGFB2 CLU 19296674 2086862 Down regulated proteins were predominantly involved with cell-cell contact and cell-matrix adhesion ( e.g. , desmocollin 2 , , collagen XVII and [transforming growth factor-beta] *induced* protein ig-h3 ) , while up-regulated proteins were proteases and factors that promote migration ( MMP-1 , kallikrein 6 , TIMP-1 , and S100A4/metastasin ) . Positive_regulation TGFB2 CTGF 15862293 1400929 is *induced* by [transforming growth factor-beta] ( TGF-beta ) via Smad activation in mesangial cells . Positive_regulation TGFB2 CTGF 16484225 1548582 is *induced* by [transforming growth factor-beta] ( TGFbeta ) in fibroblasts and is overexpressed in connective tissue disease . Positive_regulation TGFB2 CTGF 18201696 1870323 In vitro , [transforming growth factor-beta] ( TGF-beta ) *induces* expression in mesenchymal cells . Positive_regulation TGFB2 CTGF 19565505 2104336 is *induced* by [transforming growth factor beta] ( TGFbeta ) and is a mediator of some profibrotic effects of TGFbeta in vitro . Positive_regulation TGFB2 CTGF 20393108 2319802 is *induced* by [transforming growth factor-beta] ( TGF-ß ) after corneal wounding . Positive_regulation TGFB2 CTGF 23116564 2703759 [Transforming growth factor beta 2] ( TGFß2 ) *induced* the expression of fibronectin (FN) , plasminogen activator inhibitor-1 ( PAI-1 ) , and in our cell cultures . Positive_regulation TGFB2 CTGF 9925376 559370 , a 36- to 38-kDa peptide , is selectively *induced* by [transforming growth factor-beta] and has been suggested to contribute to tissue repair . Positive_regulation TGFB2 EPHB2 14630909 1201102 Expression of functional Schistosoma mansoni Smad4 : role in *mediated* [transforming growth factor beta] ( TGF-beta ) down-regulation . Positive_regulation TGFB2 EPHB2 16564547 1598078 Inhibition of the , p38 kinase or JNK signal transduction pathways *blocked* the transcriptional up-regulation of [TGF-beta2] , TbetaR1 , and TbetaR2 in KKs . Positive_regulation TGFB2 IFI27 10942583 722588 We show here that [transforming growth factor-beta] *induces* the accumulation of a form of ( Kip1 ) representing a subpopulation of total p27 ( Kip1 ) in growth arrested Mv1Lu epithelial cells . Positive_regulation TGFB2 IGFBP1 11934254 927770 [Transforming growth factor beta] ( TGF-beta ) , decorin ( a proteoglycan in the ECM ) , and melanoma cell adhesion molecule ( Mel-CAM ) inhibit , and insulin-like growth factor II (IGF-II) , , and endothelin 1 (ET-1) *stimulate* EVT cell migration/invasion . Positive_regulation TGFB2 IL1B 10540157 563255 [TGF-beta2] secretion was not *up-regulated* by stimulation with . Positive_regulation TGFB2 IL1B 12115740 964350 Freshly isolated chondrocytes , dedifferentiated chondrocytes , and synoviocytes were treated with IL-4 before determination of nitric oxide ( NO ) and collagenase production in response to IL-1beta , or before proliferation assays in *presence* of , platelet derived growth factor ( PDGF ) , or [transforming growth factor (TGF)-beta] . Positive_regulation TGFB2 IL1B 16805677 1579605 In this study , we investigated the in vitro effect of avocado and soya unsaponifiables ( ASU ) on the expression of TGF-beta1 , [TGF-beta2] , and bone morphogenetic protein-2 (BMP-2) by human periodontal ligament (HPL) and human alveolar bone ( HAB ) cells in the *presence* of . Positive_regulation TGFB2 IL1B 17013806 1666348 RT-PCR analyses showed that TNF-alpha and *increased* the mRNA levels of both TGF-beta1 and [TGF-beta2] . Positive_regulation TGFB2 IL1B 18276918 1891288 The results of in vitro studies indicated that *caused* the activation of [transforming growth factor-beta] via RhoA/alphavbeta6 integrin dependent mechanisms and the inhibition of the alphavbeta6 integrin and/or transforming growth factor-beta signaling completely blocked the IL-1beta mediated protein permeability across alveolar epithelial cell monolayers . Positive_regulation TGFB2 IL1B 7980594 281360 *induces* [transforming growth factor-beta] , ( TGF-beta 1 ) production by rat aortic smooth muscle cells . Positive_regulation TGFB2 JAG1 12039979 949575 [Transforming growth factor-beta] *induces* renal epithelial expression in fibrotic disease . Positive_regulation TGFB2 MMP28 18505915 1917817 When cancer cells were cultured on plastic , TGF-beta1 , [TGF-beta2] , and TGF-beta3 *induced* secretion , loss of cell-cell junctions , down-regulation of E-cadherin , up-regulation of N-cadherin , and acquisition of a fibroblastoid phenotype , consistent with an epithelial-to-mesenchymal transition . Positive_regulation TGFB2 MMP7 18505915 1917833 When cancer cells were cultured on plastic , TGF-beta1 , [TGF-beta2] , and TGF-beta3 *induced* secretion , loss of cell-cell junctions , down-regulation of E-cadherin , up-regulation of N-cadherin , and acquisition of a fibroblastoid phenotype , consistent with an epithelial-to-mesenchymal transition . Positive_regulation TGFB2 MUC16 15466377 1305470 [Transforming growth factor-beta2] *induces* bronchial epithelial expression in asthma . Positive_regulation TGFB2 PLAU 8126064 251291 The *role* of receptor bound ( uPA ) in cellular activation of latent [transforming growth factor-beta] ( LTGF-beta ) was investigated in a model system of mouse LB6 cells transfected with either a human uPA receptor cDNA ( LhuPAR+ ) , a human prouPA cDNA ( LhuPA ) , or a control neomycin-resistance cDNA ( Lneo ) . Positive_regulation TGFB2 SPHK1 15485866 1347360 is *induced* by [transforming growth factor-beta] and mediates TIMP-1 up-regulation . Positive_regulation TGFB2 SYNM 18637143 1960103 The upregulated hepatic protein expression of [transforming growth factor-beta] ( TGF-beta ) in *response* to was markedly attenuated by HGF gene transfer accompanied by the increased protein expression for matrix metalloproteinases (MMP)-3 and -13 . Positive_regulation TGFB2 TGM2 12763041 1093829 We have investigated the novel function of intracellular reactive oxygen species ( ROS ) in the *activation* of in situ by lysophosphatidic acid (LPA) and [transforming growth factor-beta] ( TGF-beta ) in Swiss 3T3 fibroblasts . Positive_regulation TGFB2 TGM2 7896898 299987 The activation of latent [transforming growth factor-beta] ( TGF-beta ) by vascular endothelial cells ( ECs ) is *regulated* by cellular plasminogen activator (PA)/plasmin , , and latent TGF-beta levels . Positive_regulation TGFB2 TLR7 22968409 2673484 The results demonstrated that chicken CD4+ and CD8+ T-cells express and that the various isolates of lactobacilli differentially *induces* the expression of interleukin 10 , interferon-gamma and [transforming growth factor beta] . Positive_regulation TGFB2 TNF 17013806 1666347 RT-PCR analyses showed that and IL-1beta *increased* the mRNA levels of both TGF-beta1 and [TGF-beta2] . Positive_regulation TGFB2 TNF 23171464 2700397 ( iv ) decreased secretion of , IL-12 , interferon-? and IL-2 and ( v ) but *up-regulated* IL-4 and [transforming growth factor beta] ( TGF-ß ) in the lymph nodes . Positive_regulation TGFB2 TNF 7586747 333777 *mediates* the release of bioactive [transforming growth factor-beta] in murine microglial cell cultures . Positive_regulation TGFB2 TNF 9186079 436765 Exposure to VLDL , IDL , LDL , or a high concentration of HDL *enhanced* the secretion of interleukin-6 , platelet derived growth factor , and [transforming growth factor-beta] by mesangial cells , whereas secretion was stimulated by oxidized LDL . Positive_regulation TGFB3 ALOX5 16750418 1590047 1,25-Dihydroxyvitamin D ( 3 ) ( 1,25 ( OH ) ( 2 ) D ( 3 ) ) and [transforming growth factor beta] ( TGFbeta ) potently *induce* <5-lipoxygenase (5-LO)> in myeloid cells . Positive_regulation TGFB3 CAPN8 9428805 481984 Cell associated *activation* of latent [transforming growth factor-beta] by . Positive_regulation TGFB3 CLU 10406964 629666 [Transforming growth factor-beta] ( TGFbeta ) *induces* gene expression of the glycoprotein in a variety of cell types via a consensus AP-1 binding site . Positive_regulation TGFB3 CLU 19296674 2086863 Down regulated proteins were predominantly involved with cell-cell contact and cell-matrix adhesion ( e.g. , desmocollin 2 , , collagen XVII and [transforming growth factor-beta] *induced* protein ig-h3 ) , while up-regulated proteins were proteases and factors that promote migration ( MMP-1 , kallikrein 6 , TIMP-1 , and S100A4/metastasin ) . Positive_regulation TGFB3 CTGF 11148815 761008 FCS , TGF-beta 1 , [TGF-beta 3] , bFGF , and EGF *induced* an upregulation of gene expression in RVEC in a time dependent manner . Positive_regulation TGFB3 CTGF 15862293 1400930 is *induced* by [transforming growth factor-beta] ( TGF-beta ) via Smad activation in mesangial cells . Positive_regulation TGFB3 CTGF 16484225 1548583 is *induced* by [transforming growth factor-beta] ( TGFbeta ) in fibroblasts and is overexpressed in connective tissue disease . Positive_regulation TGFB3 CTGF 18201696 1870324 In vitro , [transforming growth factor-beta] ( TGF-beta ) *induces* expression in mesenchymal cells . Positive_regulation TGFB3 CTGF 19565505 2104337 is *induced* by [transforming growth factor beta] ( TGFbeta ) and is a mediator of some profibrotic effects of TGFbeta in vitro . Positive_regulation TGFB3 CTGF 20393108 2319803 is *induced* by [transforming growth factor-beta] ( TGF-ß ) after corneal wounding . Positive_regulation TGFB3 CTGF 9925376 559371 , a 36- to 38-kDa peptide , is selectively *induced* by [transforming growth factor-beta] and has been suggested to contribute to tissue repair . Positive_regulation TGFB3 EPHB2 14630909 1201103 Expression of functional Schistosoma mansoni Smad4 : role in *mediated* [transforming growth factor beta] ( TGF-beta ) down-regulation . Positive_regulation TGFB3 IFI27 10942583 722589 We show here that [transforming growth factor-beta] *induces* the accumulation of a form of ( Kip1 ) representing a subpopulation of total p27 ( Kip1 ) in growth arrested Mv1Lu epithelial cells . Positive_regulation TGFB3 IGFBP1 11934254 927773 [Transforming growth factor beta] ( TGF-beta ) , decorin ( a proteoglycan in the ECM ) , and melanoma cell adhesion molecule ( Mel-CAM ) inhibit , and insulin-like growth factor II (IGF-II) , , and endothelin 1 (ET-1) *stimulate* EVT cell migration/invasion . Positive_regulation TGFB3 IL1B 12115740 964351 Freshly isolated chondrocytes , dedifferentiated chondrocytes , and synoviocytes were treated with IL-4 before determination of nitric oxide ( NO ) and collagenase production in response to IL-1beta , or before proliferation assays in *presence* of , platelet derived growth factor ( PDGF ) , or [transforming growth factor (TGF)-beta] . Positive_regulation TGFB3 IL1B 18276918 1891289 The results of in vitro studies indicated that *caused* the activation of [transforming growth factor-beta] via RhoA/alphavbeta6 integrin dependent mechanisms and the inhibition of the alphavbeta6 integrin and/or transforming growth factor-beta signaling completely blocked the IL-1beta mediated protein permeability across alveolar epithelial cell monolayers . Positive_regulation TGFB3 IL1B 7980594 281361 *induces* [transforming growth factor-beta] , ( TGF-beta 1 ) production by rat aortic smooth muscle cells . Positive_regulation TGFB3 IL1B 8376781 229965 selectively *induced* [TGF-beta 3] protein synthesis but reduced synthesis of the TGF-beta 1 and TGF-beta 2 isoforms . Positive_regulation TGFB3 JAG1 12039979 949576 [Transforming growth factor-beta] *induces* renal epithelial expression in fibrotic disease . Positive_regulation TGFB3 MMP28 18505915 1917840 When cancer cells were cultured on plastic , TGF-beta1 , TGF-beta2 , and [TGF-beta3] *induced* secretion , loss of cell-cell junctions , down-regulation of E-cadherin , up-regulation of N-cadherin , and acquisition of a fibroblastoid phenotype , consistent with an epithelial-to-mesenchymal transition . Positive_regulation TGFB3 MMP7 18505915 1917856 When cancer cells were cultured on plastic , TGF-beta1 , TGF-beta2 , and [TGF-beta3] *induced* secretion , loss of cell-cell junctions , down-regulation of E-cadherin , up-regulation of N-cadherin , and acquisition of a fibroblastoid phenotype , consistent with an epithelial-to-mesenchymal transition . Positive_regulation TGFB3 PLAU 8126064 251292 The *role* of receptor bound ( uPA ) in cellular activation of latent [transforming growth factor-beta] ( LTGF-beta ) was investigated in a model system of mouse LB6 cells transfected with either a human uPA receptor cDNA ( LhuPAR+ ) , a human prouPA cDNA ( LhuPA ) , or a control neomycin-resistance cDNA ( Lneo ) . Positive_regulation TGFB3 SPHK1 15485866 1347361 is *induced* by [transforming growth factor-beta] and mediates TIMP-1 up-regulation . Positive_regulation TGFB3 SYNM 18637143 1960104 The upregulated hepatic protein expression of [transforming growth factor-beta] ( TGF-beta ) in *response* to was markedly attenuated by HGF gene transfer accompanied by the increased protein expression for matrix metalloproteinases (MMP)-3 and -13 . Positive_regulation TGFB3 TGM2 12763041 1093830 We have investigated the novel function of intracellular reactive oxygen species ( ROS ) in the *activation* of in situ by lysophosphatidic acid (LPA) and [transforming growth factor-beta] ( TGF-beta ) in Swiss 3T3 fibroblasts . Positive_regulation TGFB3 TGM2 7896898 299995 The activation of latent [transforming growth factor-beta] ( TGF-beta ) by vascular endothelial cells ( ECs ) is *regulated* by cellular plasminogen activator (PA)/plasmin , , and latent TGF-beta levels . Positive_regulation TGFB3 TLR7 22968409 2673496 The results demonstrated that chicken CD4+ and CD8+ T-cells express and that the various isolates of lactobacilli differentially *induces* the expression of interleukin 10 , interferon-gamma and [transforming growth factor beta] . Positive_regulation TGFB3 TNF 23171464 2700401 ( iv ) decreased secretion of , IL-12 , interferon-? and IL-2 and ( v ) but *up-regulated* IL-4 and [transforming growth factor beta] ( TGF-ß ) in the lymph nodes . Positive_regulation TGFB3 TNF 7586747 333778 *mediates* the release of bioactive [transforming growth factor-beta] in murine microglial cell cultures . Positive_regulation TGFB3 TNF 9186079 436767 Exposure to VLDL , IDL , LDL , or a high concentration of HDL *enhanced* the secretion of interleukin-6 , platelet derived growth factor , and [transforming growth factor-beta] by mesangial cells , whereas secretion was stimulated by oxidized LDL . Positive_regulation TGFBR1 AXIN2 11438668 833096 Upon receptor activation , Smad3 was strongly phosphorylated by [TGF-beta type I receptor] ( TbetaR-I ) in the *presence* of , and dissociated from TbetaR-I and Axin . Positive_regulation TGFBR1 CCND1 10471535 641898 Our findings suggest that in some cell types cyclin D1 expression may be important for TGF-beta1 mediated signaling and that may be *involved* in the transcriptional regulation of [TbetaRI] . Positive_regulation TGIF1 EPHB2 18441095 1932703 rather , EGF stabilizes the short lived Smad transcriptional corepressor TG-interacting factor (TGIF) via *mediated* phosphorylation of [TGIF] . Positive_regulation TGIF1 MAP2K6 18441095 1932709 rather , EGF stabilizes the short lived Smad transcriptional corepressor TG-interacting factor (TGIF) via *mediated* phosphorylation of [TGIF] . Positive_regulation TGIF1 TNF 20064471 2177665 Notably , we found that activation of signaling *induced* the association of [TGIF] with Itch/AIP4 , resulting in increased accessibility of cFlip ( L ) for association and ubiquitination by Itch/AIP4 . Positive_regulation TGM1 MAP2K6 15844632 1353010 The effects on [transglutaminase-1] and AP-1 were *dependent* on protein kinase C and . Positive_regulation TGM1 TNF 1675987 160949 *had* little effect on cornified envelope formation and [transglutaminase] activity in the preconfluent cells . Positive_regulation TGM1 TNF 1675987 160963 Once keratinocytes achieved confluence , *stimulated* [transglutaminase] activity and cornified envelope formation , but inhibited 1,25- ( OH ) 2D production . Positive_regulation TGM2 ACTB 21789544 2546631 is a *target* for [transglutaminase] activity at synaptic endings in chicken telencephalic cell cultures . Positive_regulation TGM2 AKT1 17460246 1731563 *Upregulation* of TGF-beta induced [tissue transglutaminase] expression by pathway activation in human subconjunctival fibroblasts . Positive_regulation TGM2 AKT2 17460246 1731564 *Upregulation* of TGF-beta induced [tissue transglutaminase] expression by pathway activation in human subconjunctival fibroblasts . Positive_regulation TGM2 AKT3 17460246 1731565 *Upregulation* of TGF-beta induced [tissue transglutaminase] expression by pathway activation in human subconjunctival fibroblasts . Positive_regulation TGM2 CA2 11210124 763808 Substrate specificities of TGase , Ca2+ independent microbial transglutaminase ( MTGase ) , and *dependent* tissue type [transglutaminase] from guinea pig liver ( GTGase ) and fish , Red sea bream ( Pagrus major ) , liver ( FTGase ) , for acyl donors were investigated using synthetic peptides containing Gln residues and Gln analogues with different lengths of side chain . Positive_regulation TGM2 CA2 11489547 845370 A parallel increase ( +78 % ) of the *dependent* [transglutaminase] activity was detected in the spinal cord of 30 month-old rats , while no changes were apparent in the cortex and cerebellum . Positive_regulation TGM2 CA2 11853093 913332 Tissue transglutaminase (tTG) catalyzes a *dependent* [transglutaminase (TGase)] activity which cross-links proteins and stabilizes many tissues [ C.S. Greenberg et al. FASEB J. 5 ( 1991 ) 3071 ] . Positive_regulation TGM2 CA2 11913548 925050 Expression of desmoglein and [transglutaminase] was *increased* by stimulation , whereas beta1 integrin expression was decreased in response to increasing concentrations of Ca2+ . Positive_regulation TGM2 CA2 15474983 1354670 The *dependent* [tissue transglutaminase] is widely distributed in various tissues and has been reported to participate in many cellular growth and differentiation processes . Positive_regulation TGM2 CA2 16153866 1467413 The shrimp CP was able to form stable clots in vitro in the presence of hemocyte lysate and Ca2+ , suggesting that the clotting reaction is catalyzed by a *dependent* [transglutaminase] present in shrimp hemocytes . Positive_regulation TGM2 CA2 16382148 1505649 Here , we report that the *dependent* protein cross linking enzyme [tissue transglutaminase (tTGase)] is involved in THG induced p40 and p64 formation by catalyzing caspase 3 cross linking reactions , thereby inactivating caspase 3 and apoptosis in Bax-deficient cells . Positive_regulation TGM2 CA2 1679061 164801 Prevention by pentoxifylline of transient accumulation and [transglutaminase] *activation* in rat erythrocytes . Positive_regulation TGM2 CA2 2572221 119367 Bovine aortic endothelial cells contain *dependent* tissue-type [transglutaminase] . Positive_regulation TGM2 CA2 2572608 120850 Effects of pentoxifylline on *dependent* [transglutaminase] in rat erythrocytes . Positive_regulation TGM2 CA2 2572608 120864 45Ca2+ uptake , activation of *dependent* [transglutaminase] , and products of the crosslinking reaction were measured . Positive_regulation TGM2 CA2 2572608 120885 A 5 second shear promoted 45Ca2+ entry , activation of *dependent* [transglutaminase] and crosslinking of proteins in the membrane-cytoskeletal fraction . Positive_regulation TGM2 CA2 2572608 120892 Pentoxifylline , a drug that promotes erythrocyte deformability , diminished Ca2+ entry and inhibited activation of *dependent* [transglutaminase] , and had a prophylactic role on the effects of Ca2+ entry due to shear . Positive_regulation TGM2 CA2 2572608 120906 Incubation of cells with 2.5 mM pentoxifylline before swirling minimized the effects of shear on 45Ca2+ entry , *dependent* [transglutaminase] and crosslinking of proteins . Positive_regulation TGM2 CA2 2869797 55612 Membrane phospholipids , 1,2-diolein and calmodulin were found not to affect the *activation* of [transglutaminase] by . Positive_regulation TGM2 CA2 2874804 61809 We report the occurrence in pigeon erythrocytes of a soluble *dependent* [transglutaminase (TGase)] activity . Positive_regulation TGM2 CA2 6114753 15775 The cross linking processes bringing about the observed increase in polymer formation are thus the result of a *dependent* platelet [transglutaminase] activity . Positive_regulation TGM2 CA2 6147286 40104 Pancreatic islet homogenates display *dependent* [transglutaminase] activity . Positive_regulation TGM2 CA2 6150482 43151 A *dependent* [transglutaminase] ( EC 2.3.2.13 ) has been demonstrated in the eye lenses of several mammalian species [ Lorand , L. , Hsu , L. K. M. , Siefring , G. E. , Jr. , & Rafferty , N. S. ( 1981 ) Proc. Natl . Acad . Positive_regulation TGM2 CA2 6151406 44095 The concentration of polyamines found in islets were high enough for them to act as substrates for the *dependent* islet [transglutaminase] during insulin release . Positive_regulation TGM2 CA2 9778408 540375 On account of its protein crosslinking activity , the *dependent* [transglutaminase] of the lens is likely to be involved in the formation of cataracts . Positive_regulation TGM2 CA2 9792706 542699 The modification of LAV1-2 may lead to localized release of and *activation* of [transglutaminase] for walling off damaged areas of plasmodia . Positive_regulation TGM2 CALM3 14985437 1214840 *regulates* [transglutaminase 2] cross linking of huntingtin . Positive_regulation TGM2 CALM3 14985437 1214845 Because *regulates* [transglutaminase] activity in erythrocytes , platelets , and the gizzard , we hypothesized that calmodulin increases cross linking of huntingtin in the HD brain . Positive_regulation TGM2 CALM3 7945671 276568 *regulates* nucleotide hydrolysis activity of [tissue transglutaminase] . Positive_regulation TGM2 CASP1 18770781 1184933 This massively detailed unit by a pioneer in the field brings together the most common flow cytometric methods for the study of apoptosis , covering a wide variety of apoptotic indices , from loss of membrane potential , activation , and phosphatidyl exposure to DNA fragmentation and [tissue transglutaminase] *activation* . Positive_regulation TGM2 CASP10 18770781 1184934 This massively detailed unit by a pioneer in the field brings together the most common flow cytometric methods for the study of apoptosis , covering a wide variety of apoptotic indices , from loss of membrane potential , activation , and phosphatidyl exposure to DNA fragmentation and [tissue transglutaminase] *activation* . Positive_regulation TGM2 CASP12 18770781 1184944 This massively detailed unit by a pioneer in the field brings together the most common flow cytometric methods for the study of apoptosis , covering a wide variety of apoptotic indices , from loss of membrane potential , activation , and phosphatidyl exposure to DNA fragmentation and [tissue transglutaminase] *activation* . Positive_regulation TGM2 CASP14 18770781 1184935 This massively detailed unit by a pioneer in the field brings together the most common flow cytometric methods for the study of apoptosis , covering a wide variety of apoptotic indices , from loss of membrane potential , activation , and phosphatidyl exposure to DNA fragmentation and [tissue transglutaminase] *activation* . Positive_regulation TGM2 CASP16 18770781 1184945 This massively detailed unit by a pioneer in the field brings together the most common flow cytometric methods for the study of apoptosis , covering a wide variety of apoptotic indices , from loss of membrane potential , activation , and phosphatidyl exposure to DNA fragmentation and [tissue transglutaminase] *activation* . Positive_regulation TGM2 CASP2 18770781 1184936 This massively detailed unit by a pioneer in the field brings together the most common flow cytometric methods for the study of apoptosis , covering a wide variety of apoptotic indices , from loss of membrane potential , activation , and phosphatidyl exposure to DNA fragmentation and [tissue transglutaminase] *activation* . Positive_regulation TGM2 CASP3 18770781 1184937 This massively detailed unit by a pioneer in the field brings together the most common flow cytometric methods for the study of apoptosis , covering a wide variety of apoptotic indices , from loss of membrane potential , activation , and phosphatidyl exposure to DNA fragmentation and [tissue transglutaminase] *activation* . Positive_regulation TGM2 CASP4 18770781 1184938 This massively detailed unit by a pioneer in the field brings together the most common flow cytometric methods for the study of apoptosis , covering a wide variety of apoptotic indices , from loss of membrane potential , activation , and phosphatidyl exposure to DNA fragmentation and [tissue transglutaminase] *activation* . Positive_regulation TGM2 CASP5 18770781 1184939 This massively detailed unit by a pioneer in the field brings together the most common flow cytometric methods for the study of apoptosis , covering a wide variety of apoptotic indices , from loss of membrane potential , activation , and phosphatidyl exposure to DNA fragmentation and [tissue transglutaminase] *activation* . Positive_regulation TGM2 CASP6 18770781 1184940 This massively detailed unit by a pioneer in the field brings together the most common flow cytometric methods for the study of apoptosis , covering a wide variety of apoptotic indices , from loss of membrane potential , activation , and phosphatidyl exposure to DNA fragmentation and [tissue transglutaminase] *activation* . Positive_regulation TGM2 CASP7 18770781 1184941 This massively detailed unit by a pioneer in the field brings together the most common flow cytometric methods for the study of apoptosis , covering a wide variety of apoptotic indices , from loss of membrane potential , activation , and phosphatidyl exposure to DNA fragmentation and [tissue transglutaminase] *activation* . Positive_regulation TGM2 CASP8 18770781 1184942 This massively detailed unit by a pioneer in the field brings together the most common flow cytometric methods for the study of apoptosis , covering a wide variety of apoptotic indices , from loss of membrane potential , activation , and phosphatidyl exposure to DNA fragmentation and [tissue transglutaminase] *activation* . Positive_regulation TGM2 CASP9 18770781 1184943 This massively detailed unit by a pioneer in the field brings together the most common flow cytometric methods for the study of apoptosis , covering a wide variety of apoptotic indices , from loss of membrane potential , activation , and phosphatidyl exposure to DNA fragmentation and [tissue transglutaminase] *activation* . Positive_regulation TGM2 CD79A 10759247 683096 Purified and IgG *had* no effect on [transglutaminase] activity . Positive_regulation TGM2 CD79A 23982754 2920864 Furthermore , celiac patient *led* to secretion of active [transglutaminase 2] from endothelial cells into the culture supernatants . Positive_regulation TGM2 CD79A 24130874 2853363 Thioredoxin is *involved* in endothelial cell extracellular [transglutaminase 2] activation mediated by celiac disease patient . Positive_regulation TGM2 CDC42 17611083 1786696 We studied all trans-retinoic acid ( RA ) signaling in neuroblastoma cells differing in N-myc levels in terms of neurite formation , expression of [tissue transglutaminase] , neuronal marker proteins , matrix metalloproteinases ( MMPs ) , and *activation* of Rac1 and . Positive_regulation TGM2 CDC73 16453359 1528117 Through biological assays , we showed that , in HaCaT cells , causes upregulation of the keratinocyte-specific differentiation marker involucrin , *increases* the activity of the differentiation marker [transglutaminase] , and induces apoptosis at nontoxic concentrations . Positive_regulation TGM2 CDH2 23290789 2764001 [Transglutaminase-2] *induces* expression in TGF-ß1 induced epithelial mesenchymal transition via c-Jun-N-terminal kinase activation by protein phosphatase 2A down-regulation . Positive_regulation TGM2 CFTR 18490773 1917070 We have shown that a defective *induces* a remarkable up-regulation of [tissue transglutaminase] ( TG2 ) in both tissues and cell lines . Positive_regulation TGM2 CFTR 20711182 2312870 Defective *induced* upregulation of reactive oxygen species ( ROS ) and [tissue transglutaminase] ( TG2 ) drive the crosslinking of beclin 1 , leading to sequestration of phosphatidylinositol-3-kinase ( PI(3)K ) complex III and accumulation of p62 , which regulates aggresome formation . Positive_regulation TGM2 CTR9 16453359 1528118 Through biological assays , we showed that , in HaCaT cells , causes upregulation of the keratinocyte-specific differentiation marker involucrin , *increases* the activity of the differentiation marker [transglutaminase] , and induces apoptosis at nontoxic concentrations . Positive_regulation TGM2 EEF2K 24193916 2897121 Furthermore , *regulates* the expression of [tissue transglutaminase] ( TG2 ) , an enzyme previously implicated in proliferation , drug resistance and survival of cancer cells . Positive_regulation TGM2 EGF 15369700 1297140 We demonstrated that nanomolar further *enhances* [transglutaminase] activity previously induced by all-trans retinoic acid . Positive_regulation TGM2 EGF 15369700 1297146 [Transglutaminase 2] expression was *increased* by either all-trans retinoic acid or , and further up-regulated by the simultaneous addition of both substances . Positive_regulation TGM2 EGF 17108131 1645499 *Induction* of [transglutaminase 2 (TGase 2)] by in human breast cancer cells increases their oncogenic potential and chemoresistance . Positive_regulation TGM2 EGF 2444479 78523 Furthermore , *caused* a twofold increase in glucocorticoid induced epidermal [transglutaminase] activity and in the amount of epidermal glucocorticoid receptor . Positive_regulation TGM2 EGF 2892526 81186 The increase in [transglutaminase] activity could be *detected* as early as 2 min after the addition of , with the maximal response attained by 30 min . Positive_regulation TGM2 EGF 2899457 94188 In mouse primary epidermal cells , on the other hand , staurosporine failed to block the effects of phorbol 12,13-dibutyrate on binding and on *induction* of ornithine decarboxylase and epidermal [transglutaminase] . Positive_regulation TGM2 EGF 8546699 346342 [Transglutaminase] *induced* by negatively regulates the growth signal in primary cultured hepatocytes . Positive_regulation TGM2 EGFR 20004474 2199804 This induction of [TGase II] was *dependent* on FcepsilonRI and . Positive_regulation TGM2 EGFR 21525012 2439797 We found that EGF receptor (EGFR) was highly active in the TRAIL-resistant cells , and suppression of dramatically *reduced* [TGM2] expression . Positive_regulation TGM2 F13A1 1675177 157974 Cellular correspondingly disappeared and [tissue transglutaminase] *increased* during the same time . Positive_regulation TGM2 F13B 1675177 157975 Cellular correspondingly disappeared and [tissue transglutaminase] *increased* during the same time . Positive_regulation TGM2 FN1 23765377 2834171 Confocal microscopy and co-immunoprecipitation assays showed that [TGM2] interacted with integrin-a5ß1 in the *presence* of in cervical SCC cells , with OSM treatment strengthening the interaction . Positive_regulation TGM2 FN1 3654783 69249 By adding the [transglutaminase] of blood coagulation , FXIII , in the *presence* of , the attachment of PER cells to collagen I monomers could be recovered while the minimal concentration of fibronectin needed to promote their adhesion to polymers was lowered . Positive_regulation TGM2 FOS 23592781 2794988 We demonstrate that *regulates* induction of [TGase2] expression after wounding but does not affect expression of the components of the well characterized complement-like system . Positive_regulation TGM2 HGF 8598211 351291 *induces* [transglutaminase] activity that negatively regulates the growth signal in primary cultured hepatocytes . Positive_regulation TGM2 HOXD13 11168987 783244 The in vitro synthesis of PPC from human plasma was carried out by means of the enzyme [transglutaminase] in the *presence* of either [ 3H ] -labeled or unlabeled . Positive_regulation TGM2 HPGDS 9356496 461928 We now report that purified glyceraldehyde 3-phosphate dehydrogenase is inactivated by [tissue transglutaminase] in the *presence* of constructs containing a Qn domain of pathological length ( n = 62 or 81 ) . Positive_regulation TGM2 HPR 10357800 618406 Here , we report that stable expression of the dominant negative construct RARalpha403 fails to blunt growth inhibition and [TGase II] *induction* by <4-HPR> , a potent chemopreventive retinoid , in the same cells . Positive_regulation TGM2 HPR 10357800 618407 These data show that retinoic acid receptors do not mediate either growth inhibition or *induction* of [TGase II] activity by <4-HPR> in mouse fibroblast cells . Positive_regulation TGM2 IFNB1 7905929 245861 inhibited growth of the NCI-H596 cell line and *stimulated* envelope competence , involucrin expression , and type 2 [transglutaminase] activity . Positive_regulation TGM2 IFNG 12162878 972252 *induces* [transglutaminase 2] expression in rat small intestinal cells . Positive_regulation TGM2 IFNG 12162878 972254 *increased* mRNA and [TGase 2] activity by about 2-fold in 24 h and 5-fold by 5 days . Positive_regulation TGM2 IFNG 12162878 972255 Our new data suggest that increased [TGase 2] expression in the upper small intestine of CD patients may be *due* to increased expression , loss of TGF-beta signaling , or both . Positive_regulation TGM2 IFNG 2857744 46373 *requires* serum retinoids to promote the expression of [tissue transglutaminase] in cultured human blood monocytes . Positive_regulation TGM2 IL17A 24116291 2714693 As an alternative cell culture system for NHKs , HaCaT cells can be used to study molecular mechanisms associated with abnormal HBD2 and [TGM2] expression in *response* to IFN? , IL-4 or . Positive_regulation TGM2 IL1A 24265865 2869845 All together , OPG and [Tgase-2] is *induced* by or TPA in MG-63 cells and Tgase-2 is involved in OPG expression in MG-63 cells . Positive_regulation TGM2 IL4 24116291 2714694 As an alternative cell culture system for NHKs , HaCaT cells can be used to study molecular mechanisms associated with abnormal HBD2 and [TGM2] expression in *response* to IFN? , or IL-17A . Positive_regulation TGM2 IL6 9582307 503872 Retinoid and *inductions* of [tissue transglutaminase] expression are mediated by specific cis-regulatory elements located within the first 4.0 kilobase pairs of the promoter of the gene . Positive_regulation TGM2 ITGAV 11686302 875845 Treatment of fibroblasts with transforming growth factor beta ( TGFbeta ) significantly *increases* surface expression of [transglutaminase] and its association with beta1 integrins , but not with . Positive_regulation TGM2 ITGB3 11686302 875846 Treatment of fibroblasts with transforming growth factor beta ( TGFbeta ) significantly *increases* surface expression of [transglutaminase] and its association with beta1 integrins , but not with . Positive_regulation TGM2 IVL 8844461 387549 Immunohistochemistry of and *activation* of [transglutaminase] activity provided further evidence for the increase in corneocyte envelope formation observed ultrastructurally . Positive_regulation TGM2 JUN 23290789 2764004 Suppression of Tgase-2 or the inhibitor , SP600125 , significantly reduced and over-expression of [Tgase-2] *increased* the expression of N-cadherin . Positive_regulation TGM2 KRT1 9988703 596867 Expression of the early ( spinous ) differentiation marker decreased in response to 1 , 25 ( OH ) 2D3 over 12-24 h. Treatment with 1,25 ( OH ) 2D3 *enhanced* the activity of [transglutaminase] , a late ( granular ) differentiation marker , by 12 h with a maximal increase after 24 h . Positive_regulation TGM2 LEO1 16453359 1528121 Through biological assays , we showed that , in HaCaT cells , causes upregulation of the keratinocyte-specific differentiation marker involucrin , *increases* the activity of the differentiation marker [transglutaminase] , and induces apoptosis at nontoxic concentrations . Positive_regulation TGM2 LGALS3BP 20049854 2200692 Cyclophilin C-associated colocalizes with calnexin and *regulates* the expression of [tissue transglutaminase] . Positive_regulation TGM2 LPA 12763041 1093834 We have investigated the novel function of intracellular reactive oxygen species ( ROS ) in the *activation* of in situ [tissue transglutaminase (tTGase)] by and transforming growth factor-beta ( TGF-beta ) in Swiss 3T3 fibroblasts . Positive_regulation TGM2 LTB 2907327 103317 Moreover , prostaglandin E2 ( PGE2 ) , a main product of the cyclooxygenase pathway , , a product of 5-lipoxygenase , and arachidonic acid also could directly *induce* high levels of intracellular [transglutaminase] activity without stimulation of macrophages by SRBC or IgG coated SRBC , but leukotriene C4 , prostaglandin D2 , and prostacyclin were unable to induce high activity of the enzyme . Positive_regulation TGM2 LTB 2907327 103324 Enhancement of [transglutaminase] activity *induced* by was inhibited by cyclooxygenase inhibitor , but the enzyme activity induce by PGE2 was not inhibited . Positive_regulation TGM2 MAGEE1 9792706 542692 of plasmodia by brief treatment with 15 % ethanol *activates* the [transglutaminase] , with rapid accumulation of cross linked proteins unable to enter gels during SDS-polyacrylamide gel electrophoresis . Positive_regulation TGM2 MASP1 12396008 1008652 As an example , does cleave fibrinogen , releasing fibrinopeptide B ( a chemotactic factor ) and also cleaves and *activates* plasma [transglutaminase] ( Factor XIII ) . Positive_regulation TGM2 MT-CO2 17618715 1787012 During the study period , the fertilization effect dominated ozone and climatic stresses ( temperature and precipitation ) , and the combination of these multiple factors *resulted* in net accumulation of [0.9Tg C] in this ecosystem . Positive_regulation TGM2 MTX1 16511354 1530703 The *activation* of [tissue transglutaminase] and ERK1/2 by was sup pressed by BAPTA-AM or ROS scavengers . Positive_regulation TGM2 MYLIP 22294552 2551808 The data showed that [transglutaminase 2 (TGM2)] was directly *regulated* by . Positive_regulation TGM2 NFKB1 17108131 1645503 Therefore , increased expression of [TGase 2] and subsequent *activation* of may contribute to drug resistance in breast cancer cells independently of EGF signaling . Positive_regulation TGM2 NFKB1 18295389 1885723 *activated* [tissue transglutaminase] is involved in ethanol induced hepatic injury and the possible role of propolis in preventing fibrogenesis . Positive_regulation TGM2 NGF 2887561 77184 In contrast to sodium butyrate , did not *stimulate* [tissue transglutaminase] in PC12 cells , although it , too , caused growth arrest . Positive_regulation TGM2 NGF 7916448 269798 Blockade effect of on GM1 ganglioside *induced* activation of [transglutaminase] in superior cervical sympathetic ganglia excised from adult rat . Positive_regulation TGM2 OSMR 23765377 2834172 This combined tissue and in vitro study demonstrates for the first time that stimulation of over expressed in cervical SCC cells *activates* [TGM2/integrin-a5ß1] interactions and induces pro-malignant changes . Positive_regulation TGM2 PAF1 16453359 1528119 Through biological assays , we showed that , in HaCaT cells , causes upregulation of the keratinocyte-specific differentiation marker involucrin , *increases* the activity of the differentiation marker [transglutaminase] , and induces apoptosis at nontoxic concentrations . Positive_regulation TGM2 PIK3CA 17460246 1731566 *Upregulation* of TGF-beta induced [tissue transglutaminase] expression by pathway activation in human subconjunctival fibroblasts . Positive_regulation TGM2 PIK3R1 17460246 1731567 *Upregulation* of TGF-beta induced [tissue transglutaminase] expression by pathway activation in human subconjunctival fibroblasts . Positive_regulation TGM2 PLA2G1B 2907327 103303 Enhancement of the intracellular [transglutaminase] activity was observed on stimulation of macrophages with normal sheep red blood cells (SRBC) or immunoglobulin G ( IgG ) -coated SRBC , and was *inhibited* by inhibitors of and cyclooxygenase . Positive_regulation TGM2 PML 22136669 2568501 TGA seem to enhance [TGM2] expression in both cell models , but expression was *induced* only in T84 enterocytes while GNA13 and ERBB2 were repressed in HUVEC endothelial cells , with several genes showing discordant effects in each model , highlighting the complexity of gene interactions in the pathogenesis of CD . Positive_regulation TGM2 PML 8634442 357348 Retinoid induced differentiation of acute promyelocytic leukemia involves *mediated* increase of type II [transglutaminase] . Positive_regulation TGM2 PTHLH 15901283 1409121 The *induction* of [TGC] formation by correlated with downregulation of cyclin B1 and mSNA expression , but upregulation of cyclin D1 , thus allowing mitotic-endocycle transition . Positive_regulation TGM2 RAC1 17611083 1786697 We studied all trans-retinoic acid ( RA ) signaling in neuroblastoma cells differing in N-myc levels in terms of neurite formation , expression of [tissue transglutaminase] , neuronal marker proteins , matrix metalloproteinases ( MMPs ) , and *activation* of and Cdc42 . Positive_regulation TGM2 RAC1 17680210 1842391 *role* of and FAK in the induction of [transglutaminase II] . Positive_regulation TGM2 RAI1 11854287 929321 Phosphoinositide 3-kinase activity is required for expression and *activation* of the [tissue transglutaminase] . Positive_regulation TGM2 RAI14 11854287 929320 Phosphoinositide 3-kinase activity is required for expression and *activation* of the [tissue transglutaminase] . Positive_regulation TGM2 RAI2 11854287 929322 Phosphoinositide 3-kinase activity is required for expression and *activation* of the [tissue transglutaminase] . Positive_regulation TGM2 RARA 7890733 299557 Evidence for the involvement of retinoic acid receptor *dependent* signaling pathway in the induction of [tissue transglutaminase] and apoptosis by retinoids . Positive_regulation TGM2 RARA 8634442 357349 Retinoid induced differentiation of acute promyelocytic leukemia involves *mediated* increase of type II [transglutaminase] . Positive_regulation TGM2 RARRES3 15846304 1398983 These findings suggest that forms a complex with transglutaminase resulting in transglutaminase activation and that [transglutaminase] activity is *required* for the TIG3 dependent biological response . Positive_regulation TGM2 RARS 8709622 376548 Our data suggest that ligand activation of RARs in HL-60 cells results in a global suppression of BCL-2 expression whereas ligand activation of both and RXRs *triggers* the selective accumulation of [tissue transglutaminase] in the apoptotic HL-60 cells . Positive_regulation TGM2 RBP1 6149218 42205 Our studies suggest that retinoic acid and serum can directly regulate macrophage gene expression and specifically *induce* the synthesis of [tissue transglutaminase] . Positive_regulation TGM2 RBP2 6149218 42206 Our studies suggest that retinoic acid and serum can directly regulate macrophage gene expression and specifically *induce* the synthesis of [tissue transglutaminase] . Positive_regulation TGM2 RBP3 6149218 42207 Our studies suggest that retinoic acid and serum can directly regulate macrophage gene expression and specifically *induce* the synthesis of [tissue transglutaminase] . Positive_regulation TGM2 RBP4 6149218 42208 Our studies suggest that retinoic acid and serum can directly regulate macrophage gene expression and specifically *induce* the synthesis of [tissue transglutaminase] . Positive_regulation TGM2 RBP5 6149218 42203 Our studies suggest that retinoic acid and serum can directly regulate macrophage gene expression and specifically *induce* the synthesis of [tissue transglutaminase] . Positive_regulation TGM2 RBP7 6149218 42204 Our studies suggest that retinoic acid and serum can directly regulate macrophage gene expression and specifically *induce* the synthesis of [tissue transglutaminase] . Positive_regulation TGM2 RELA 17108131 1645504 Therefore , increased expression of [TGase 2] and subsequent *activation* of may contribute to drug resistance in breast cancer cells independently of EGF signaling . Positive_regulation TGM2 RELA 18295389 1885724 *activated* [tissue transglutaminase] is involved in ethanol induced hepatic injury and the possible role of propolis in preventing fibrogenesis . Positive_regulation TGM2 RPE65 19635990 2138099 The results showed that ET-1 did not influence the basal transglutaminase activity of cardiomyocytes but significantly inhibited the <0.1-mmol/L Ca(2+)> *stimulated* [transglutaminase] activity . Positive_regulation TGM2 SERPINB3 9627690 408268 alone *increased* [transglutaminase] and cornified envelope levels . Positive_regulation TGM2 SFTPC 21840417 2505629 *induces* the expression of [Tgase-2] in a time- and dose dependent manner . Positive_regulation TGM2 SFTPC 21840417 2505630 Therefore , *induced* [Tgase-2] might be a new target for modulating keratin reorganization , metastasis of cancer cells and JNK activation . Positive_regulation TGM2 SFTPC 24244820 2869393 *induced* JNK activation through [Tgase-2] expression and ECA suppressed the activation and expression of JNK in PANC-1 cells . Positive_regulation TGM2 SRI 7890733 299558 We show that the RAR-selective retinoid strongly *increased* [TGase II] expression at both the protein and mRNA levels , whereas the RXR-selective retinoid SR11217 had little effect . Positive_regulation TGM2 STSP1 10223183 609673 Both TPA and *increased* [transglutaminase] activity , a marker of late differentiation , whereas bradykinin had little or no effect on either cell proliferation or transglutaminase activity . Positive_regulation TGM2 SYN1 8095260 211908 Covalent modification of by a tetanus toxin *activated* [transglutaminase] . Positive_regulation TGM2 TEC 19013523 2022435 The *up-regulation* and trafficking of [tissue transglutaminase] ( TG2 ) by has been implicated in the development of kidney scarring . Positive_regulation TGM2 TFRC 22451718 2583043 interaction *induced* mesangial surface expression of [TGase2] ( transglutaminase 2 ) , which in turn up-regulated TfR1 expression . Positive_regulation TGM2 TGFB1 10505687 649222 This study suggests that in the IPRK and in the absence of other exogenous growth factors , selectively *increases* the synthesis of ECM and [tissue transglutaminase] without changes that would result in the reduction of ECM degradation . Positive_regulation TGM2 TGFB1 10892867 711331 *Induction* of [tissue transglutaminase] in the trabecular meshwork by and TGF-beta2 . Positive_regulation TGM2 TGFB1 12763041 1093831 We have investigated the novel function of intracellular reactive oxygen species ( ROS ) in the *activation* of in situ [tissue transglutaminase (tTGase)] by lysophosphatidic acid (LPA) and ( TGF-beta ) in Swiss 3T3 fibroblasts . Positive_regulation TGM2 TGFB1 1352692 190372 ( TGF-beta 1 ) *enhanced* Type II [transglutaminase] activity about 10-fold in the undifferentiated cells but did not increase Type I transglutaminase or cholesterol sulfate , two early markers of squamous differentiation . Positive_regulation TGM2 TGFB1 15284217 1277862 Molecular consequences of MTF-1 loss include increased expression and *activation* of the ( TGF-beta1 ) and [tissue transglutaminase (tTG)] , two proteins with documented roles in the production and stabilization of extracellular matrix (ECM) . Positive_regulation TGM2 TGFB1 1972706 135381 did not enhance the levels of the membrane bound Type I ( epidermal ) transglutaminase activity which is induced during squamous cell differentiation and did not *increase* Type II [transglutaminase] activity in differentiated NHEK cells . Positive_regulation TGM2 TGFB1 1972706 135395 however , did not *induce* any significant change in [transglutaminase] activity in the carcinoma derived cell lines SCC-13 , SCC-15 , and SQCC/Y1 . Positive_regulation TGM2 TGFB2 10892867 711332 *Induction* of [tissue transglutaminase] in the trabecular meshwork by TGF-beta1 and . Positive_regulation TGM2 TGFB2 12763041 1093832 We have investigated the novel function of intracellular reactive oxygen species ( ROS ) in the *activation* of in situ [tissue transglutaminase (tTGase)] by lysophosphatidic acid (LPA) and ( TGF-beta ) in Swiss 3T3 fibroblasts . Positive_regulation TGM2 TGFB3 12763041 1093833 We have investigated the novel function of intracellular reactive oxygen species ( ROS ) in the *activation* of in situ [tissue transglutaminase (tTGase)] by lysophosphatidic acid (LPA) and ( TGF-beta ) in Swiss 3T3 fibroblasts . Positive_regulation TGM2 TNF 1675987 160950 *had* little effect on cornified envelope formation and [transglutaminase] activity in the preconfluent cells . Positive_regulation TGM2 TNF 1675987 160964 Once keratinocytes achieved confluence , *stimulated* [transglutaminase] activity and cornified envelope formation , but inhibited 1,25- ( OH ) 2D production . Positive_regulation TGM2 TXN 21908620 2496790 *Activation* of extracellular [transglutaminase 2] by . Positive_regulation TGM2 TXN 23327656 2742920 For example , *activates* extracellular [transglutaminase 2 (TG2)] via reduction of an intramolecular disulfide bond . Positive_regulation TGM2 WDR61 16453359 1528120 Through biological assays , we showed that , in HaCaT cells , causes upregulation of the keratinocyte-specific differentiation marker involucrin , *increases* the activity of the differentiation marker [transglutaminase] , and induces apoptosis at nontoxic concentrations . Positive_regulation TGM2 WT1 17259349 1691267 Knockdown of PDCD4 by RNA interference ( siRNA ) inhibited ATRA induced granulocytic differentiation and reduced expression of key proteins known to be regulated by ATRA , including p27 ( Kip1 ) and DAP5/p97 , and *induced* c-myc and , but did not alter expression of c-jun , p21 ( Waf1/Cip1 ) , and [tissue transglutaminase] ( TG2 ) . Positive_regulation TGM3 TNF 1675987 160951 *had* little effect on cornified envelope formation and [transglutaminase] activity in the preconfluent cells . Positive_regulation TGM3 TNF 1675987 160965 Once keratinocytes achieved confluence , *stimulated* [transglutaminase] activity and cornified envelope formation , but inhibited 1,25- ( OH ) 2D production . Positive_regulation TGM4 TNF 1675987 160952 *had* little effect on cornified envelope formation and [transglutaminase] activity in the preconfluent cells . Positive_regulation TGM4 TNF 1675987 160966 Once keratinocytes achieved confluence , *stimulated* [transglutaminase] activity and cornified envelope formation , but inhibited 1,25- ( OH ) 2D production . Positive_regulation TGM5 TNF 1675987 160953 *had* little effect on cornified envelope formation and [transglutaminase] activity in the preconfluent cells . Positive_regulation TGM5 TNF 1675987 160967 Once keratinocytes achieved confluence , *stimulated* [transglutaminase] activity and cornified envelope formation , but inhibited 1,25- ( OH ) 2D production . Positive_regulation TGM6 TNF 1675987 160954 *had* little effect on cornified envelope formation and [transglutaminase] activity in the preconfluent cells . Positive_regulation TGM6 TNF 1675987 160968 Once keratinocytes achieved confluence , *stimulated* [transglutaminase] activity and cornified envelope formation , but inhibited 1,25- ( OH ) 2D production . Positive_regulation TGM7 TNF 1675987 160955 *had* little effect on cornified envelope formation and [transglutaminase] activity in the preconfluent cells . Positive_regulation TGM7 TNF 1675987 160969 Once keratinocytes achieved confluence , *stimulated* [transglutaminase] activity and cornified envelope formation , but inhibited 1,25- ( OH ) 2D production . Positive_regulation TH IL1B 19309436 2073460 Moreover , regulates catecholamine synthesis as the inhibition of tyrosine hydroxylase decreases IL-1beta evoked catecholamine release and the cytokine *induces* [tyrosine hydroxylase] Ser40 phosphorylation . Positive_regulation TH IL1B 19544469 2128849 We showed that *induced* a rapid induction of mRNA of dopaminergic key fate determining transcription factors , such as Nurr1 and Pitx3 , and a subsequent increase of [tyrosine hydroxylase] protein as an early marker for dopaminergic neurons in vitro . Positive_regulation TH IL1B 7919198 272776 *stimulates* [tyrosine hydroxylase] activity in the median eminence . Positive_regulation TH MAOA 2877718 64408 [Tyrosine hydroxylase] and activity *increases* in differentiating human neuroblastoma after elimination of dividing cells . Positive_regulation TH SLC6A2 9460652 475775 [Tyrosine hydroxylase] and mRNA levels *increase* in locus coeruleus after coitus in rabbits . Positive_regulation THBD TNF 10602073 655219 Endothelial cells ( EC ) from human aortas , microvessels , and pulmonary arteries were examined for their expression and activity of monocyte chemotactic protein-1 (MCP-1) , tissue factor , and [thrombomodulin] in *response* to on the hydrophilic plasma polymers gamma-butyrolactone ( GBL ) and N-vinyl-2-pyrrolidone ( NVP ) , along with a fibronectin (FN) control . Positive_regulation THBD TNF 16996955 1618042 Stimulation with *resulted* in physiologic upregulation of tissue factor and downregulation of [thrombomodulin] expression . Positive_regulation THBD TNF 7769287 308531 These results provide evidence for an E. coli dose related and *dependent* [thrombomodulin] release into the plasma of septic baboons and suggest a possible role of anti-TNF in protection of the endothelium . Positive_regulation THBD TNF 8747795 344096 is *involved* in the production of endothelin-1 and [thrombomodulin] , which play a role in the pathogenesis of DIC and whose blood levels reflect its severity . Positive_regulation THBD TNF 8822923 384855 [Thrombomodulin] expression in endothelial cells is *regulated* by retinoic acid and , agents that also modulate epidermal differentiation . Positive_regulation THBD TNF 8822923 384858 These results demonstrate that keratinocyte [thrombomodulin] is *regulated* by retinoids and Ca2+ , but not by , and that regulation of thrombomodulin expression differs in keratinocytes and endothelial cells . Positive_regulation THBS1 ADAMTS1 20103648 2201974 Collectively , our results indicate that the antiangiogenic activity of [TSP1] is differentially *regulated* by in the liver and lung , emphasizing the concept that regulation of angiogenesis is varied in different tissue environments . Positive_regulation THBS1 F2R 24127927 2853262 Aspirin use also decreased *mediated* release of [TSP-1] and VEGF from platelets . Positive_regulation THBS1 FAS 11927940 927198 The anti-angiogenic activity of [thrombospondin-1] and pigment epithelium derived factor both in vitro and in vivo was *dependent* on this dual induction of and FasL and the resulting apoptosis . Positive_regulation THBS1 FOXO1 23677673 2838402 overexpression *induced* [THBS1] production , and a direct interaction of endogenous FoxO1 with the THBS1 promoter was detectable in primary endothelial cells . Positive_regulation THBS1 FOXO1 23677673 2838404 We provide evidence that directly *regulates* [THBS1] within ischemic muscle . Positive_regulation THBS1 ID1 21307796 2457926 negatively *regulates* [TSP-1] expression in AVM-ECs . Positive_regulation THBS1 MAMLD1 11358957 834493 Conversely , binding of to TSP1 *enhanced* [TSP1] binding to fibronectin . Positive_regulation THBS1 MAMLD1 11358957 834500 Furthermore , binding to or fibronectin strongly *enhanced* the adhesive activity of immobilized [TSP1] for some cell types . Positive_regulation THBS1 PLAU 10917542 716778 Tumour cell [thrombospondin-1] *induced* a 2-7 fold increase in receptor and cell associated urokinase plasminogen activator expression and a 50-65 % increase in cell associated urokinase plasminogen activator and plasmin activities . Positive_regulation THBS1 TNF 17046999 1635828 The G1 domain of versican contains two Link modules , which are known to mediate *stimulated* gene-6 protein binding to [thrombospondin-1] , and the related G1 domain of aggrecan is also recognized by thrombospondin-1 . Positive_regulation THBS1 TNF 22492973 2613132 In late CL cells , TNF and TNF+IFNG+FASL reduced VEGFR2 mRNA , but *increased* [TSP1] and CD36 mRNA . Positive_regulation THRA EDN2 8147869 252667 [TRAP] *induced* rapid morphological changes in HUVECs , with marked increase in the release of prostacyclin , , platelet activating factor , tissue type plasminogen activator , and plasminogen activator inhibitor-1 . Positive_regulation THRA PLAT 8147869 252670 [TRAP] *induced* rapid morphological changes in HUVECs , with marked increase in the release of prostacyclin , endothelin , platelet activating factor , , and plasminogen activator inhibitor-1 . Positive_regulation THRAP3 EDN2 8147869 252687 [TRAP] *induced* rapid morphological changes in HUVECs , with marked increase in the release of prostacyclin , , platelet activating factor , tissue type plasminogen activator , and plasminogen activator inhibitor-1 . Positive_regulation THRAP3 PLAT 8147869 252690 [TRAP] *induced* rapid morphological changes in HUVECs , with marked increase in the release of prostacyclin , endothelin , platelet activating factor , , and plasminogen activator inhibitor-1 . Positive_regulation THY1 TNF 8752941 374382 Inhibition studies showed that the *induction* of [Thy-1] by PBu and was protein synthesis dependent . Positive_regulation TIA1 TNF 12949814 1137154 These findings support the hypothesis that *induced* [TIA-1] overexpression might sensitize endothelial cells to proapoptotic stimuli present in the tumor microenvironment and enhance NK cell cytotoxic activity against cancer cells . Positive_regulation TIE1 ANGPT1 10625301 658521 *induced* phosphorylation of [Tie2] and the p85 subunit of phosphatidylinositol 3'-kinase ( PI 3'-kinase ) and increased PI 3'-kinase activity in a dose dependent manner . Positive_regulation TIE1 ANGPT1 10854239 704243 and angiopoietin-2 *activate* trophoblast [Tie-2] to promote growth and migration during placental development . Positive_regulation TIE1 ANGPT1 11230987 789432 ( 200 ng/ml ) *induced* [Tie2] phosphorylation , while Ang2 ( 200 ng/ml ) did not produce Tie2 phosphorylation . Positive_regulation TIE1 ANGPT1 11348459 814392 *induces* [Tie2] signaling as a receptor activator and maintains blood vessel formation , whereas angiopoietin 2 destabilizes vessels by blocking Tie2 signaling as an antagonist of angiopoietin 1 and acts with vascular endothelial growth factor to initiate angiogenesis . Positive_regulation TIE1 ANGPT1 11441305 835359 which binds to and *activates* [TIE-2] is obviously responsible for the stabilization of vessels under homeostatic conditions . Positive_regulation TIE1 ANGPT1 11801735 902905 Ang2 is known to inhibit *mediated* phosphorylation of [Tie2] as well as cellular responses during embryonic development . Positive_regulation TIE1 ANGPT1 12039842 954272 Accordingly , ephrinB2 inhibited VEGF- and Ang1 induced Ras-MAPK activities , whereas ephrinB2 did not alter VEGF induced Flk phosphorylation or *induced* [Tie2] phosphorylation . Positive_regulation TIE1 ANGPT1 12783598 1096367 Two of the Angs , Ang-1 and Ang-4 , activate the Tie2 receptor , whereas Ang-2 and Ang-3 inhibit *induced* [Tie2] phosphorylation . Positive_regulation TIE1 ANGPT1 12810673 1102837 *activates* the endothelial cell-specific tyrosine kinase receptor [Tie-2] , which in turn leads to enhanced endothelial cell survival and stabilization . Positive_regulation TIE1 ANGPT1 12876214 1115305 *mediated* activation of [Tie2] promotes perivascular mural cell assembly , but the mechanisms regulating this process are poorly understood because differentiated mural cells do not have the Tie2 receptor , which is reportedly expressed only in endothelial cells . Positive_regulation TIE1 ANGPT1 14665640 1218765 *Stimulation* of endogenous [Tie2] in endothelial cells with its ligand increased its association with ShcA and phosphorylation of the adapter protein . Positive_regulation TIE1 ANGPT1 14742253 1203394 *mediated* modulation of [Tie2] activation contributes to normal vessel development and stability , however , its role in tumor angiogenesis is not well known . Positive_regulation TIE1 ANGPT1 15284088 1302561 Ang-2 is produced by endothelial cells and acts as an autocrine regulator mediating vascular destabilization by inhibiting mediated [Tie-2] *activation* . Positive_regulation TIE1 ANGPT1 15501241 1327035 VEGF treatment of cultured smooth muscle cells (SMC) upregulated Tie2 and allowed for *mediated* phosphorylation of [Tie2] and the AKT serine-threonine kinase . Positive_regulation TIE1 ANGPT1 15769741 1403630 In conclusion , proper oligomerization of having at least four subunits by the intermolecular disulfide linkage involving cysteines 41 and 54 is *critical* for [Tie2] binding and activation . Positive_regulation TIE1 ANGPT1 15817675 1425071 Exogenous VEGF-A and *stimulated* [Tie2] expression in the BM vasculature . Positive_regulation TIE1 ANGPT1 15851516 1399528 The phosphorylation of overexpressed [Tie1] was weakly *induced* by also in transfected cells that do not express Tie2 . Positive_regulation TIE1 ANGPT1 15851516 1399530 [Tie1] phosphorylation was also *induced* by native and Ang4 , although less efficiently than with COMP-Ang1 . Positive_regulation TIE1 ANGPT1 15885574 1406808 produced by OBs *activates* [Tie2] on HSCs and promotes tight adhesion of HSCs to the niche , resulting in quiescence and enhanced survival of HSCs . Positive_regulation TIE1 ANGPT1 16778190 1573172 It is also known that *activates* [Tie2] , an endothelial-specific tyrosine kinase receptor , but the molecular mechanism of this process is not clear . Positive_regulation TIE1 ANGPT1 16875629 1593552 *activates* [Tie-2] receptor , whereas Ang-2 antagonizes Ang-1 in the angiogenesis , and the Ang-2/Ang-1 ratio determines angiogenesis and tumor growth in gastric cancers . Positive_regulation TIE1 ANGPT1 16895971 1601121 *Activation* of [Tie2] by and angiopoietin-2 results in their release and receptor internalization . Positive_regulation TIE1 ANGPT1 16895971 1601123 Activation of [Tie2] by these ligands *resulted* in differential turnover of the receptor where binding of , and to a lesser extent angiopoietin-2 , induced rapid internalization and degradation of Tie2 . Positive_regulation TIE1 ANGPT1 17045842 1641818 mediated [Tie2] *activation* is required to maintain the quiescent resting state of the endothelium . Positive_regulation TIE1 ANGPT1 17341311 1712269 Our results suggest that although both and Ang2 can *activate* the [Tie-2] receptor in bmLECs , Ang1 and Ang2 may have distinct roles in mesenteric lymphatic endothelial cells . Positive_regulation TIE1 ANGPT1 17544375 1751905 Autologous secretion of by transduced EC *resulted* in [Tie-2] activation and in the presence of SMC expressing VEGF resulted in coordinated sprouting in vitro and increase in flow and number of arteries in vivo . Positive_regulation TIE1 ANGPT1 18425119 1907990 Here , we show that *induces* unique [Tie2] complexes in mobile and confluent endothelial cells . Positive_regulation TIE1 ANGPT1 18425119 1907991 Matrix bound *induced* cell adhesion , motility and [Tie2] activation in cell-matrix contacts that became translocated to the trailing edge in migrating endothelial cells . Positive_regulation TIE1 ANGPT1 18425119 1907992 In contrast , in contacting cells *induced* Tie2 translocation to cell-cell contacts and the formation of homotypic [Tie2-Tie2] trans associated complexes that included the vascular endothelial phosphotyrosine phosphatase , leading to inhibition of paracellular permeability . Positive_regulation TIE1 ANGPT1 18425119 1907995 Distinct signalling proteins were preferentially activated by Tie2 in the cell-matrix and cell-cell contacts , where Ang2 inhibited *induced* [Tie2] activation . Positive_regulation TIE1 ANGPT1 18556567 1946042 gene transfer *restored* [Tie-2] expression and rescued these abnormalities in diabetes . Positive_regulation TIE1 ANGPT1 18565279 1929493 This study showed that MSC expressed [Tie-2] receptor , and *induced* Tie-2 receptor phosphorylation . Positive_regulation TIE1 ANGPT1 18799719 2028374 Ang-2 and Tie-1 downregulate *induced* [Tie-2] signaling , and angiopoietin actions are further modified by vascular endothelial growth factor A and integrins . Positive_regulation TIE1 ANGPT1 19037734 2001594 A nuclease-resistant RNA aptamer specifically inhibits mediated [Tie2] *activation* and function . Positive_regulation TIE1 ANGPT1 19116766 2036941 Hypoxia , which upregulated HPTPbeta expression in endothelial cells , impaired *induced* [Tie2] phosphorylation . Positive_regulation TIE1 ANGPT1 19116989 2036942 In contrast , binding of *induces* [Tie2] receptor activation and supports the formation of mature blood vessels covered by pericytes . Positive_regulation TIE1 ANGPT1 19449109 2096784 acts in a paracrine agonistic manner *inducing* [Tie2] phosphorylation and subsequent vessel stabilization . Positive_regulation TIE1 ANGPT1 19449109 2096785 In contrast , Ang-2 is produced by endothelial cells and acts as an autocrine antagonist of mediated [Tie2] *activation* . Positive_regulation TIE1 ANGPT1 19615361 2124095 The major intracellular signaling systems activated by [Tie2] in *response* to include the Akt and Erk1/2 pathways . Positive_regulation TIE1 ANGPT1 19815705 2154453 Ang2 blocks *mediated* activation of [Tie2] in endothelial cells under certain conditions but is a Tie2 receptor agonist in others . Positive_regulation TIE1 ANGPT1 19922791 2184706 However , in endothelial cells *activates* [Tie2] whereas Ang2 can act as an apparent antagonist . Positive_regulation TIE1 ANGPT1 20227369 2223729 To address the role of Tie1 in *mediated* [Tie2] signaling and determine the basis for the behavior of the individual angiopoietins , we used an in vivo FRET based proximity assay to monitor Tie1 and -2 localization and association . Positive_regulation TIE1 ANGPT1 20227369 2223738 Based on the available data , we propose a unified model for *induced* [Tie2] signaling . Positive_regulation TIE1 ANGPT1 20357108 2231702 The proneurogenic effect of is *mediated* by [Tie-2] activation and subsequent mTOR ( mammalian target of rapamycin kinase ) mobilization . Positive_regulation TIE1 ANGPT1 20453494 2275448 PD98059 substantially reduced senescence while not altering *stimulated* [phosphor-Tie2] stimulation . Positive_regulation TIE1 ANGPT1 21113176 2372204 ( 250 ng/mL ) *increased* [Tie-2] activation , inhibited cell apoptosis , and promoted angiogenesis . Positive_regulation TIE1 ANGPT1 21273558 2403167 Primary monocytes regulate endothelial cell survival through secretion of and *activation* of endothelial [Tie2] . Positive_regulation TIE1 ANGPT1 21273558 2403169 The direct interaction of primary monocytes with subconfluent endothelial cells resulted in transient secretion of from monocytes and the *activation* of endothelial [Tie2] . Positive_regulation TIE1 ANGPT1 22235284 2537955 To assess the impact of this on Ang1 signalling cells were stimulated with VEGF and TNFa for differing times and *induced* [Tie2] phosphorylation examined . Positive_regulation TIE1 ANGPT1 22357955 2606193 We show here that Ang2 , but not , *induces* [Tie2] translocation to the specific cell-matrix contact sites located at the distal end of focal adhesions . Positive_regulation TIE1 ANGPT1 23149917 2723015 *activates* [Tie2] to promote blood vessel maturation and stabilization . Positive_regulation TIE1 ANGPT1 23770419 2815305 Hypoxia reduces endothelial *induced* [Tie2] activity in a Tie1 dependent manner . Positive_regulation TIE1 ANGPT1 23770419 2815309 In this study , we found that hypoxia increased Tie receptor expression but attenuated *induced* [Tie2] activity , including Tie2 phosphorylation , Tie2 downstream signaling activation , and endothelial cell tube formation . Positive_regulation TIE1 ANGPT1 23770419 2815310 These results suggest that under hypoxic conditions , Tie1 is critical for reducing *induced* [Tie2] activity and angiogenesis . Positive_regulation TIE1 ANGPT1 8980223 403724 Although binds and *induces* the tyrosine phosphorylation of [TIE2] , it does not directly promote the growth of cultured endothelial cells . Positive_regulation TIE1 RARB 18439490 1900430 We showed that RARgamma , but not RARalpha or , is *required* for [Tie1] promoter activation by RA . Positive_regulation TIE1 TNF 10969034 728328 *induced* [Tie2] in a time- and dose dependent fashion in all 3 EC types ( HUVEC , 2.3-fold ; Positive_regulation TIE1 TNF 13130465 1140033 Primary cultured endothelial cells and synoviocytes were used to study *induced* [Tie2] and Ang1 expression . Positive_regulation TIE1 TNF 13130465 1140035 In addition , we observed that can *regulate* [Tie2] activation in multiple ways that may involve interactions between endothelial cells and synoviocytes . Positive_regulation TIE1 TNF 15370298 1297367 Both Ang1 and Ang2 attenuated *induced* [Tie2] up-regulation . Positive_regulation TIE1 TNF 16803639 1579429 RGD targeted adenovirus delivered the dnIkappaB via alphavbeta3 to become functionally expressed , leading to complete abolishment of *induced* up-regulation of E-selectin , ICAM-1 , VCAM-1 , IL-6 , IL-8 , VEGF-A and [Tie-2] . Positive_regulation TIE1 TNF 23065888 2689964 *up-regulated* the gene expression of VEGF , Angiopoietin-2 , and [Tie2] ( p < 0.05 ) . Positive_regulation TIFA TNF 10920205 722519 IL-1 , but not , *induces* [TRAF6-T6BP] complex formation in a ligand dependent manner . Positive_regulation TIMP1 EPHB2 23457635 2749572 These data show that 1/2-selective inhibitors *block* IL-1ß induced astrocyte [TIMP-1] expression , but did not decrease C/EBPß expression in parallel . Positive_regulation TIMP1 IGFBP1 9778118 540330 In contrast , *increased* the total gelatinolytic activity and [TIMP-1] , had no effect on MMP-2 , MMP-9 or fFN but inhibited hCG . Positive_regulation TIMP1 IGFBP1 9786460 540887 In contrast , *increased* the total gelatinolytic activity and [TIMP-1] and had no effect on MMP-2 and MMP-9 . Positive_regulation TIMP1 IL1B 10836722 698055 [TIMP-1] levels also were significantly *increased* by , and its expression was slightly decreased by amlodipine , not by nifedipine . Positive_regulation TIMP1 IL1B 11029344 739829 Airway macrophages from smokers released greater amounts of MMP-9 and [TIMP-1] at baseline and in *response* to and LPS than did those of nonsmokers . Positive_regulation TIMP1 IL1B 15458430 1301523 TNF-alpha and *mediated* regulation of MMP-9 and [TIMP-1] in renal proximal tubular cells . Positive_regulation TIMP1 IL1B 17706606 1789076 *increased* release of MMP-2 , -3 , and -9 , and [TIMP-1] , by 3-6-fold , measured by immunoblotting and gel zymography . Positive_regulation TIMP1 IL1B 17890880 1811203 TNF-alpha and *mediated* regulation of MMP-9 and [TIMP-1] in human glomerular mesangial cells . Positive_regulation TIMP1 IL1B 17890880 1811212 TNF-alpha but not *resulted* in a dose dependent increase in the latent form of MMP-9 and a decrease in [TIMP-1] production . Positive_regulation TIMP1 IL1B 18570937 1930038 RT-PCR analyses revealed membrane type 1 (MT1)-MMP mRNA levels , not MMP-2 or [tissue inhibitor of MMP (TIMP)] , were significantly *increased* by , and Western blot analyses confirmed a significant increase in MT1-MMP protein in response to Est alone . Positive_regulation TIMP1 IL1B 18577571 1930283 Interestingly , protein secretion and mRNA production of [TIMP-1] were significantly *stimulated* by . Positive_regulation TIMP1 IL1B 18577571 1930284 Thus , *induced* [TIMP-1] secretion in a dose dependent manner with maximal 3.5-fold upregulation seen at 0.67 ng/ml IL-1 beta relative to untreated cells . Positive_regulation TIMP1 IL1B 18577571 1930286 Furthermore , [TIMP-1] mRNA synthesis was significantly *stimulated* by in a dose dependent fashion with 2.5-fold induction seen at IL-1 beta concentrations as low as 0.02 ng/ml and maximal 8.1-fold upregulation found at 20 ng/ml effector . Positive_regulation TIMP1 IL1B 18577571 1930287 Signaling studies suggested that janus kinase 2 is involved in *induced* [TIMP-1] mRNA expression . Positive_regulation TIMP1 IL1B 20053983 2258638 Pirfenidone was more effective than dexamethasone in inhibiting *induced* increases in [TIMP-1] , reducing TIMP-1 levels to less than those in untreated controls at a minimal concentration ( 5 mM ) . Positive_regulation TIMP1 IL1B 20471972 2288521 Inhibitory effects of baicalin on *induced* [MMP-1/TIMP-1] and its stimulated effect on collagen-I production in human periodontal ligament cells . Positive_regulation TIMP1 IL1B 7752115 306813 MMP-1 , MMP-3 , and [TIMP-1] expression and synthesis were *induced* in cultured human synoviocytes with recombinant human in the absence or presence of either chemical inhibitors of protein kinase A and C ( PKA , PKC ) , or prostaglandin E2 , or cyclic AMP ( cAMP ) mimetics . Positive_regulation TIMP1 IL1B 8045300 266888 [TIMP-1] protein expression is *stimulated* by and IL-6 in primary rat hepatocytes . Positive_regulation TIMP1 IL1B 8045300 266890 In primary rat hepatocytes we show for the first time that [TIMP-1] protein expression is up-regulated upon *stimulation* with and IL-6 . Positive_regulation TIMP1 IL1B 8093049 272049 The inhibitory effect of heparin was specific to transin , and *induction* of procollagen alpha 1 ( IV ) , laminin B2 or [TIMP-1] by was not affected . Positive_regulation TIMP1 IL1B 8898888 393140 We found that transforming growth factor beta 1 as well as *induce* gene expression of both [TIMP-1] and TIMP-3 . Positive_regulation TIMP1 IL1B 9357863 462076 Divergent regulation of 92-kDa gelatinase and [TIMP-1] by HBECs in *response* to and TNF-alpha . Positive_regulation TIMP1 IL1B 9357863 462086 In contrast , [TIMP-1] production evaluated by immunoblotting was unchanged in the *presence* of LPS and and was clearly decreased in the presence of TNF-alpha . Positive_regulation TIMP1 IL1B 9357863 462088 Quantitative RT-PCR demonstrated that [TIMP-1] mRNA levels remained unchanged in *response* to LPS or but decreased by 70 % in the presence of TNF-alpha . Positive_regulation TIMP1 IL1B 9589682 505334 We have investigated the *roles* of and transforming growth factor-beta ( TGF beta ) in regulating [TIMP-1] , TIMP-3 , and 92-kDa type IV collagenase messenger ribonucleic acid ( mRNA ) expression in human endometrial stromal cells using quantitative competitive PCR . Positive_regulation TIMP1 IL1B 9648064 515096 TGF-beta 1 : TNF-alpha and TGF-beta 1 : *induced* additive increases in [TIMP-1] ( tissue inhibitor of metalloproteinases-1 ) mRNA levels . Positive_regulation TIMP1 IL1B 9727371 529938 When the secretion of the regulatory inhibitors was examined , or TGF-beta1 both *resulted* in an increased secretion of [TIMP-I] , whereas the secretion of TIMP-II was downregulated . Positive_regulation TIMP1 IL1B 9743373 532502 TNF-alpha , granulocyte-macrophage-CSF (GM-CSF) , or when added individually *enhanced* the endogenous levels of 92-kDa gelatinase ( MMP-9 ) and [TIMP-1] but failed to induce interstitial collagenase ( MMP-1 ) . Positive_regulation TIMP1 IL1B 9821179 548085 The inflammatory cytokine did not *induce* MMP or [TIMP] expression . Positive_regulation TIMP1 MMP28 11960708 932429 We examined the expression patterns of two inhibitors , tissue *inhibitor* of metalloproteinase ( [TIMP] ) -2 and TIMP-3 , during critical stages of cardiac development . Positive_regulation TIMP1 MMP28 18273688 1937946 The enhancing activity of [TIMP-1] was *dependent* , since a mutant version of TIMP-1 was unable to promote angiogenesis . Positive_regulation TIMP1 MMP28 23016931 2694388 [TIMP-1] *increased* in the APPSwDI/NOS2 ( -/- ) mice with decreased activity and increased amyloid burden , thereby supporting roles for NO in the regulation of MMP/TIMP balance and plaque clearance . Positive_regulation TIMP1 MMP28 9433928 474573 The results suggest that MMP and [TIMP] expression in leiomyoma and myometrium are hormonally *regulated* , and that GnRHa induced tumour regression is accompanied by an increase in expression with a concomitant decrease in TIMP-1 expression , which may potentially provide an environment favouring ECM degradation . Positive_regulation TIMP1 MMP7 11960708 932444 We examined the expression patterns of two inhibitors , tissue *inhibitor* of metalloproteinase ( [TIMP] ) -2 and TIMP-3 , during critical stages of cardiac development . Positive_regulation TIMP1 MMP7 18273688 1937961 The enhancing activity of [TIMP-1] was *dependent* , since a mutant version of TIMP-1 was unable to promote angiogenesis . Positive_regulation TIMP1 MMP7 20146992 2208283 In the mean time MMP-2 and MMP-3 , as well as [TIMP-1] , -2 and TIMP-4 concentrations were not affected by significant weight loss , and circulating *increased* significantly after bariatric surgery , although without reaching the standard levels as determined in 18 , lean , healthy women . Positive_regulation TIMP1 MMP7 22461511 2595026 Moreover , the fibromuscular stroma surrounding prostatic glands was relatively thicker in IL-17RC ( - ) mice and was associated with decreased expression and *increased* [Timp1] , 2 , and 4 expression , whereas administration of recombinant mouse IL-17 induced prostatic expression of Mmp7 . Positive_regulation TIMP1 MMP7 23016931 2694403 [TIMP-1] *increased* in the APPSwDI/NOS2 ( -/- ) mice with decreased activity and increased amyloid burden , thereby supporting roles for NO in the regulation of MMP/TIMP balance and plaque clearance . Positive_regulation TIMP1 MMP7 9433928 474588 The results suggest that MMP and [TIMP] expression in leiomyoma and myometrium are hormonally *regulated* , and that GnRHa induced tumour regression is accompanied by an increase in expression with a concomitant decrease in TIMP-1 expression , which may potentially provide an environment favouring ECM degradation . Positive_regulation TIMP1 SPHK1 15485866 1347365 We demonstrate that decreasing SphK1 expression by small interfering RNA ( siRNA ) blocked TGF-beta mediated up-regulation of TIMP-1 protein suggesting that up-regulation of *contributes* to the induction of [TIMP-1] in response to TGF-beta . Positive_regulation TIMP1 TLR7 23223421 2803387 This study demonstrates profibrotic properties of circulating monocytes from patients with SSc and a key *role* for signalling , particularly TLR8 , in [TIMP-1] secretion and matrix remodelling . Positive_regulation TIMP1 TNF 11404256 825285 In conclusion , *induction* by of upregulation of both the 92-kDa gelatinase and its inhibitor [TIMP-1] results in maintenance of the gelatinase-inhibitor balance , indicating that basement membrane degradation does not mediate the TNF-alpha induced increase in alveolar epithelial monolayer permeability . Positive_regulation TIMP1 TNF 11687525 875943 Agents that modulate protein kinase A (PKA) or inhibit phosphatidylinositol 3-kinase (PI3K) had minimal effects on trabecular MMP or [TIMP] *induction* by , whereas several agents that modulate PKC activity were effective . Positive_regulation TIMP1 TNF 11762950 887866 These results indicate a central role of MMPs in *mediated* tissue damage in vivo and a promising therapeutic role for [TIMP-1] . Positive_regulation TIMP1 TNF 12147614 970036 The mRNA levels of MMP-1 , -2 , and -3 and [TIMP-1] were markedly *increased* by and TGF-beta(2) . Positive_regulation TIMP1 TNF 12480812 1024244 In cultured neonatal rat cardiac fibroblasts , reduced cellular [ 3H ] -proline incorporation , increased matrix metalloproteinase-2 (MMP-2) activity and protein , and *increased* [TIMP-1] protein levels . Positive_regulation TIMP1 TNF 12606436 1064597 The production of [TIMP-1] in BT-1 cells was also *augmented* by IL-1alpha , , and HGF at the level of translation and was transcriptionally increased by 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation TIMP1 TNF 12927975 1131934 However , significantly *increases* [TIMP-1] protein levels . Positive_regulation TIMP1 TNF 14673992 1178610 The in vivo data clearly indicated that OSM + overexpression *increased* MMP levels and decreased levels of [tissue inhibitor of metalloproteinases 1] ( TIMP-1 ) . Positive_regulation TIMP1 TNF 16288749 1484450 Interestingly , and IL-6 *induced* [TIMP-1] protein secretion more than 3- and 2-fold , respectively . Positive_regulation TIMP1 TNF 16476037 1524201 The mRNA expression of MMP-1 and-2 was suppressed by PHT , while [TIMP-1] mRNA expression was *enhanced* by both and PHT . Positive_regulation TIMP1 TNF 17890880 1811211 but not IL-1 beta *resulted* in a dose dependent increase in the latent form of MMP-9 and a decrease in [TIMP-1] production . Positive_regulation TIMP1 TNF 17890880 1811244 The cytokine *causes* different effects on human mesangial MMP-9 and [TIMP-1] expression which are mediated through the TNF-RI , and the different signalling pathways of PKC , ERK 1/2 and p38 MAPK . Positive_regulation TIMP1 TNF 21142900 2366350 In addition , the levels of monocyte chemoattractant protein-1 ( MCP-1 ) and were decreased , and [tissue inhibitor of metalloproteinases-1] ( TIMP-1 ) and vascular endothelial growth factor ( VEGF ) levels were *increased* at 4 weeks in both the IM-C and IM-I groups . Positive_regulation TIMP1 TNF 23370854 2818511 We here investigated the effect of CK ( 0-5 µM ) on *induced* MMP-1 , MMP-3 , and MMP-13 and [TIMP-1] production from RA fibroblast-like synoviocytes ( FLS ) and determined the inhibitory effect of CK on osteoclastogenesis from RAW264.7 cells co-cultured with RA-FLS and from human CD14+ monocytes . Positive_regulation TIMP1 TNF 24193164 2879323 On reverse zymography , inhibitory activity of [TIMP-1] but not TIMP-2 was significantly *increased* by and LPS . Positive_regulation TIMP1 TNF 24279124 2876949 In cultured vascular smooth muscle cells ( SMCs ) , significantly *activated* both Mmp9 and [Timp1] expression , and they were blocked by Jun kinase inhibitor ( SP600125 ) in a dose dependent manner . Positive_regulation TIMP1 TNF 24279124 2876953 Interestingly , a proteasome inhibitor ( MG132 ) , which is known as an agent for inhibition of the nuclear factor-kappa B (NF-kappaB) , significantly inhibited the *induced* expression of [Timp1] , whereas MG132 , which also works as an activator of c-Jun/AP-1 pathway , strongly increased Mmp9 . Positive_regulation TIMP1 TNF 7558248 327966 The presence of suppresses maturation induced transcription of MMP-2 , *enhances* [TIMP-1] transcription , but has little effect on MMP-9 mRNA levels . Positive_regulation TIMP1 TNF 9357863 462075 Divergent regulation of 92-kDa gelatinase and [TIMP-1] by HBECs in *response* to IL-1beta and . Positive_regulation TIMP1 TNF 9543636 498190 A phorbol mitogen ( TPA ) , and and beta , interleukin-1 alpha and PDGF BB *stimulate* gelatinase B , stromelysin , interstitial collagenase and [TIMP-1] expression , while having negligible effects on gelatinase A expression ; Positive_regulation TIMP1 TNF 9743373 532500 , granulocyte-macrophage-CSF (GM-CSF) , or IL-1 beta when added individually *enhanced* the endogenous levels of 92-kDa gelatinase ( MMP-9 ) and [TIMP-1] but failed to induce interstitial collagenase ( MMP-1 ) . Positive_regulation TIMP1 TNF 9743373 532510 Th2 cytokines , such as IL-4 , inhibited the *induction* of MMPs and [TIMP-1] by , GM-CSF , and IL-1 . Positive_regulation TIMP1 TNF 9927150 588404 In general , *stimulated* both MMP and [TIMP] expression of hepatic stellate cells , while TGF-beta1 induced TIMP expression only . Positive_regulation TIMP2 EPHB2 16904070 1601383 signaling *regulates* concanavalin A-dependent production of [TIMP-2] . Positive_regulation TIMP2 IL1B 11678909 873739 KE-298 blocked this IL-1beta induced pro-MMP-2 activation and MT1-MMP expression , but did not affect *induced* [tissue inhibitor of metalloproteinase-2] ( TIMP-2 ) secretion from rheumatoid synovial cells . Positive_regulation TIMP2 IL1B 18950946 2041298 Our results showed that ( 10 ng/ml ) *stimulated* a statistically significant increase in MCP-1 and MMP-2 production and decreased production of [TIMP-2] by both normal and keloid derived fibroblasts ( Student 's t-test , p < 0.05 ) , but to differing extents . Positive_regulation TIMP2 MMP28 15920147 1413549 Reverse transcriptase-polymerase chain reaction demonstrated that increased activity was due , at least in part , to increased transcription and that [TIMP-2] transcripts *increased* in embolic myxomas . Positive_regulation TIMP2 MMP28 17067460 1637577 Furthermore , the expression of [TIMP-2] consequently *increased* with the increasing of the , but the increase of TIMP-2 was less than that of MMP . Positive_regulation TIMP2 MMP28 24418973 2942396 We determined the level of the ECM proteases urokinase-like plasminogen activator ( uPA ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous inhibitors , tissue *inhibitors* of metalloproteinase ( TIMP ) -1 and [TIMP-2] in the conditioned media . Positive_regulation TIMP2 MMP7 15920147 1413564 Reverse transcriptase-polymerase chain reaction demonstrated that increased activity was due , at least in part , to increased transcription and that [TIMP-2] transcripts *increased* in embolic myxomas . Positive_regulation TIMP2 MMP7 17067460 1637592 Furthermore , the expression of [TIMP-2] consequently *increased* with the increasing of the , but the increase of TIMP-2 was less than that of MMP . Positive_regulation TIMP2 MMP7 24418973 2942411 We determined the level of the ECM proteases urokinase-like plasminogen activator ( uPA ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous inhibitors , tissue *inhibitors* of metalloproteinase ( TIMP ) -1 and [TIMP-2] in the conditioned media . Positive_regulation TIMP2 PLAT 10615432 575814 Furthermore , in both cell types , the secretion of [TIMP-2] was *enhanced* by and PDGF , but not by uPA or bFGF . Positive_regulation TIMP2 PLAU 10615432 575815 Furthermore , in both cell types , the secretion of [TIMP-2] was *enhanced* by tPA and PDGF , but not by or bFGF . Positive_regulation TIMP2 PLAU 24418973 2942414 We determined the level of the ECM proteases urokinase-like plasminogen activator ( ) , matrix metalloproteinase (MMP)-2 and MMP-9 , and endogenous MMP *inhibitors* , tissue inhibitors of metalloproteinase ( TIMP ) -1 and [TIMP-2] in the conditioned media . Positive_regulation TIMP2 TNF 24193164 2879324 On reverse zymography , inhibitory activity of TIMP-1 but not [TIMP-2] was significantly *increased* by and LPS . Positive_regulation TIMP3 EPHB2 18559520 1924018 [TIMP-3] induction was *mediated* by activation . Positive_regulation TIMP3 IL1B 11694815 877150 and transforming growth factor-beta1 ( TGF-beta1 ) *increased* MMP-3 and [TIMP-3] expressions in A549 cells in a time- and concentration dependent manner . Positive_regulation TIMP3 IL1B 8898888 393142 We found that transforming growth factor beta 1 as well as *induce* gene expression of both TIMP-1 and [TIMP-3] . Positive_regulation TIMP3 IL1B 8898888 393147 After oncostatin M treatment , TIMP-1 expression was up-regulated but basal , as well as *induced* , [TIMP-3] expression was inhibited . Positive_regulation TIMP3 IL1B 9589682 505338 We have investigated the *roles* of and transforming growth factor-beta ( TGF beta ) in regulating TIMP-1 , [TIMP-3] , and 92-kDa type IV collagenase messenger ribonucleic acid ( mRNA ) expression in human endometrial stromal cells using quantitative competitive PCR . Positive_regulation TIMP3 MMP28 10645926 661795 Tissue *inhibitor* of metalloproteinase-3 ( [TIMP-3] ) , an extracellular matrix associated inhibitor , uniquely promotes apoptosis of isolated vascular smooth muscle cells . Positive_regulation TIMP3 MMP7 10645926 661810 Tissue *inhibitor* of metalloproteinase-3 ( [TIMP-3] ) , an extracellular matrix associated inhibitor , uniquely promotes apoptosis of isolated vascular smooth muscle cells . Positive_regulation TIMP3 TNF 9749945 533249 had no effect on the TIMP-1 and TIMP-2 mRNA levels and did not *induce* [TIMP-3] or TIMP-4 expression . Positive_regulation TIMP4 F2R 20422465 2274545 Although matrix metalloproteinase-9 (MMP-9) is involved in cardiomyocytes contractility dysfunction , [tissue inhibitor of metalloproteinase-4] ( TIMP-4 ) mitigates the effect of MMP-9 , and ( PAR-1 , a G-protein couple receptor , GPCR ) is *involved* in the signaling cascade of MMP-9 mediated cardiac dysfunction , the mechanism ( s ) are unclear . Positive_regulation TIMP4 MMP7 20146992 2208284 In the mean time MMP-2 and MMP-3 , as well as TIMP-1 , -2 and [TIMP-4] concentrations were not affected by significant weight loss , and circulating *increased* significantly after bariatric surgery , although without reaching the standard levels as determined in 18 , lean , healthy women . Positive_regulation TIMP4 TNF 9749945 533250 had no effect on the TIMP-1 and TIMP-2 mRNA levels and did not *induce* TIMP-3 or [TIMP-4] expression . Positive_regulation TINAGL1 NPNT 23663413 2791170 APOA1 , DCN and expression was higher in cyclic compared to pregnant heifers , and pregnancy *increased* ( P < 0.05 ) the expression of LCAT , NCDN , NMN , PLIN2 and [TINAGL1] . Positive_regulation TINF2 EPHB2 12402047 1009415 We conclude that cAMP induced regulation of and *activation* of [Rap1] are independent processes . Positive_regulation TINF2 F2R 15078882 1251918 Concomitant stimulation of both and PAR-4 in the presence of ADP scavengers still *resulted* in a strongly reduced activation of [Rap1B] . Positive_regulation TINF2 FLG 17045653 1666569 Using a Rap1-GTP pull-down assay , we found that stimulation , but not LPS , of avian heterophils *induced* a rapid and transient [Rap1] activation . Positive_regulation TINF2 FLG 17045653 1666590 We show here that stimulation of heterophils *induces* the phosphorylation of [Rap1] . Positive_regulation TINF2 ITGAL 24486015 2928143 The gap junction protein connexin43 (Cx43) regulates B lymphocyte adhesion , BCR- and mediated *activation* of the GTPase [Rap1] , and cytoskeletal rearrangements resulting in changes to cell shape and membrane spreading . Positive_regulation TINF2 PECAM1 10725328 677539 Importantly , selectively *activated* the small Ras related GTPase , [Rap1] , but not Ras , R-Ras , or Rap2 . Positive_regulation TIRAP CAPN8 23023391 2689713 In dendritic cells , we found that the p110d isoform of phosphatidylinositol-3-OH kinase ( PI(3)K ) induced internalization of TLR4 and dissociation of TIRAP from the plasma membrane , followed by *mediated* degradation of [TIRAP] . Positive_regulation TIRAP ITGB2 18701460 1974017 Activation of p38 MAPK is also essential for the initiation of LPS uptake , and interestingly , we show that this activation is not through TLR4 signaling by MyD88 but through *activation* of [TIRAP] via . Positive_regulation TIRAP TLR7 16239509 1471012 We also determined that MyD88 , IRAK , TRAF6 , and Toll interacting protein (Tollip) , but not [TIRAP] , were involved in the *mediated* response to P. aeruginosa in HAECs . Positive_regulation TJP1 ANGPT1 21772310 2509914 Compared with VEGF expression alone , coexpression of with VEGF *resulted* in upregulation of [tight junction protein] expression and reduction of Evans blue leakage ( AAV-ANG1/AAV-VEGF : 1.4 ± 0.3 versus AAV-VEGF : 2.8 ± 0.7 , P=0.001 ) . Positive_regulation TJP1 ARSA 22917627 2683144 We measured whether *induced* the increase of differentiated Caco-2 permeability , the decrease of tight junction protein expression , the production of reactive oxygen species ( ROS ) , and the expression of ROS modified [zonula occludens-1 (ZO-1)] protein . Positive_regulation TJP1 ARSA 22917627 2683146 However , MnTMPyP suppressed the ASA induced increased intercellular permeability and the *induced* ROS modified [ZO-1] expression . Positive_regulation TJP1 CAPN8 15784649 1417205 Prolonged positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ( AMPA ) receptors induces *mediated* [PSD-95/Dlg/ZO-1] protein degradation and AMPA receptor down-regulation in cultured hippocampal slices . Positive_regulation TJP1 EMP1 20435084 2268240 *induced* BBB [tight junction protein ZO-1] translocation was also inhibited . Positive_regulation TJP1 EMP1 20435084 2268243 Our data indicated that PKC signaling was involved in *induced* BBB permeability change and [ZO-1] translocation in rat . Positive_regulation TJP1 IL1B 18230110 1864211 Irsogladine maleate counters the interleukin-1 beta induced suppression in gap-junctional intercellular communication but does not affect the *induced* [zonula occludens protein-1] levels in human gingival epithelial cells . Positive_regulation TJP1 IL1B 18230110 1864212 decreased connexin 43 mRNA levels , but *increased* [zonula occludens protein-1] mRNA levels . Positive_regulation TJP1 PECAM1 19281230 2063742 Furthermore , DEN-2 infection caused decreased expression and redistribution of both VE-cadherin and [ZO-1] , whose changes were *enhanced* by engagement . Positive_regulation TJP1 PLAT 22244977 2564153 GM6001 significantly reduced tPA elevated brain hemoglobin , MMP-9 , and inhibited the degradation of occludin and [ZO-1] *induced* by , but not claudin-5 . Positive_regulation TJP1 TNF 19772664 2147495 The *roles* of in colon [tight junction protein] expression and intestinal mucosa structure in a mouse model of acute liver failure . Positive_regulation TJP1 TNF 23671580 2785124 Berberine also dramatically alleviated IFN-? and *induced* morphological alteration of tight junction proteins [ZO-1] , occluding , and claudin-1 . Positive_regulation TJP2 ANGPT1 19148554 2026684 Herein , we examined whether could *regulate* [zonula occludens-2 (ZO-2)] expression and counteract vascular endothelial growth factor ( VEGF ) -induced vascular permeability . Positive_regulation TJP2 ANGPT1 19148554 2026686 When we treated brain microvascular endothelial cells with Ang-1 , *caused* a time- and dose dependent increase of [ZO-2] and down-regulation in endothelial permeability . Positive_regulation TJP2 ANGPT1 21772310 2509915 Compared with VEGF expression alone , coexpression of with VEGF *resulted* in upregulation of [tight junction protein] expression and reduction of Evans blue leakage ( AAV-ANG1/AAV-VEGF : 1.4 ± 0.3 versus AAV-VEGF : 2.8 ± 0.7 , P=0.001 ) . Positive_regulation TJP2 TNF 19772664 2147496 The *roles* of in colon [tight junction protein] expression and intestinal mucosa structure in a mouse model of acute liver failure . Positive_regulation TJP3 ANGPT1 21772310 2509916 Compared with VEGF expression alone , coexpression of with VEGF *resulted* in upregulation of [tight junction protein] expression and reduction of Evans blue leakage ( AAV-ANG1/AAV-VEGF : 1.4 ± 0.3 versus AAV-VEGF : 2.8 ± 0.7 , P=0.001 ) . Positive_regulation TJP3 TNF 19772664 2147497 The *roles* of in colon [tight junction protein] expression and intestinal mucosa structure in a mouse model of acute liver failure . Positive_regulation TLN1 CAPN8 10545199 564432 To explore the physiological significance of the *mediated* cleavage of [talin] , we analyzed the behavior of the calpain generated fragments of talin ( N-terminal 47 kDa and C-terminal 190 kDa ) during platelet activation by biochemical and immunoelectron microscopic studies . Positive_regulation TLN1 CAPN8 10545505 564572 Thus , collagen fragments induce distinct integrin signals that lead to initiation of *mediated* cleavage of pp125(FAK) , paxillin , and [talin] and dissolution of the focal adhesion complex . Positive_regulation TLN1 CAPN8 12490576 1033273 The goal of the present study was to determine the *role* of in changes in plasma membrane permeability and cytoskeleton associated paxillin , vinculin , [talin] , and alpha-actinin levels during acute renal cell death . Positive_regulation TLN1 CAPN8 19363486 2065037 Thus , talin head produced by *induced* cleavage of [talin] is degraded through Smurf1 mediated ubiquitylation ; Positive_regulation TLN1 CAPN8 20709086 2340973 Altogether , our results reveal that *dependent* cleavage of [talin] modulates cell contractile dynamics , which in pericytes may prove instrumental in controlling normal capillary function or microvascular pathophysiology . Positive_regulation TLN1 CAPN8 22665520 2611027 Here , we identify a novel *dependent* proteolytic cleavage of [talin] that results in the release of a 70-kD C-terminal fragment , which serves as a substrate of posttranslational arginylation . Positive_regulation TLN1 TNS1 15030759 1223162 The localization of *requires* integrins , [talin] , and integrin linked kinase . Positive_regulation TLN2 CAPN8 10545199 564446 To explore the physiological significance of the *mediated* cleavage of [talin] , we analyzed the behavior of the calpain generated fragments of talin ( N-terminal 47 kDa and C-terminal 190 kDa ) during platelet activation by biochemical and immunoelectron microscopic studies . Positive_regulation TLN2 CAPN8 10545505 564586 Thus , collagen fragments induce distinct integrin signals that lead to initiation of *mediated* cleavage of pp125(FAK) , paxillin , and [talin] and dissolution of the focal adhesion complex . Positive_regulation TLN2 CAPN8 12490576 1033287 The goal of the present study was to determine the *role* of in changes in plasma membrane permeability and cytoskeleton associated paxillin , vinculin , [talin] , and alpha-actinin levels during acute renal cell death . Positive_regulation TLN2 CAPN8 19363486 2065051 Thus , talin head produced by *induced* cleavage of [talin] is degraded through Smurf1 mediated ubiquitylation ; Positive_regulation TLN2 CAPN8 20709086 2340987 Altogether , our results reveal that *dependent* cleavage of [talin] modulates cell contractile dynamics , which in pericytes may prove instrumental in controlling normal capillary function or microvascular pathophysiology . Positive_regulation TLN2 CAPN8 22665520 2611041 Here , we identify a novel *dependent* proteolytic cleavage of [talin] that results in the release of a 70-kD C-terminal fragment , which serves as a substrate of posttranslational arginylation . Positive_regulation TLN2 TNS1 15030759 1223166 The localization of *requires* integrins , [talin] , and integrin linked kinase . Positive_regulation TLR1 CD14 23548899 2788980 Similarly , soluble *augmented* the [TLR2/TLR1] response to curli fibers in the absence of membrane bound CD14 . Positive_regulation TLR1 IL1B 17459804 1731499 Secretion of the proinflammatory cytokine *requires* caspase-1 and [Toll-like receptor (TLR)] signaling . Positive_regulation TLR1 IL1B 17467812 1737384 [TLR] stimulation of RA-FLS also *induced* the production of and TNF-alpha to a lesser extent ; Positive_regulation TLR1 IL1B 18832719 1971206 A phosphatidylserine species inhibits a range of [TLR-] but not *induced* inflammatory responses by disruption of membrane microdomains . Positive_regulation TLR1 IL1B 19019013 2047260 Interleukins ( IL1beta ) and bacterial products ( E. coli LPS ) stimulated 5HT secretion from Crohn 's EC cells via [TIL] receptor *activation* ( TLR4 and ) . Positive_regulation TLR1 IL1B 19961871 2204164 was the most potent *inducer* of [tIL-17C2] but only had a minor effect on the expression of tIL-17C1 . Positive_regulation TLR1 IL1B 20200276 2229576 Caspase-1 independent production is critical for host resistance to mycobacterium tuberculosis and does not *require* [TLR] signaling in vivo . Positive_regulation TLR1 IL1B 8666926 369198 We describe here the fine specificity of three distinct gammadelta+ [tumor infiltrating lymphocytes (TIL)] obtained from patients with primary or metastatic colorectal cancer , that could be readily expanded in vitro in the *presence* of and IL-7 . Positive_regulation TLR1 LBP 16159572 1455959 could significantly *increase* the numbers of CD4 ( + ) and CD8 ( + ) T cells in [TIL] as compared with those in model control group ( P < 0.05 ) . Positive_regulation TLR1 SELL 23573259 2768069 [Toll-Like Receptor] *induced* CD11b and response in patients with coronary artery disease . Positive_regulation TLR1 TNF 12133979 967069 Moreover , various [TLR] ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* NF-kappa B activation and up-regulated production in osteoclast precursor cells . Positive_regulation TLR1 TNF 16847431 1600275 Etanercept , a humanized soluble recombinant p75 TNF-receptor/IgG ( 1 ) Fc fusionprotein , neutralized synergistic CXCL9 production *induced* by plus IFN-gamma , but not synergy between IFN-gamma and the [TLR] ligands PGN or LPS . Positive_regulation TLR1 TNF 17467812 1737383 [TLR] stimulation of RA-FLS also *induced* the production of IL-1beta and to a lesser extent ; Positive_regulation TLR1 TNF 19454685 2084518 [TLR] activation *induces* production from adult neural stem/progenitor cells . Positive_regulation TLR1 TNF 20148136 2208395 Although secretion by adipose cells is probably *induced* , most notably by [TLR] ligands , the activation and secretion pathways of this cytokine are not yet entirely understood . Positive_regulation TLR10 IL1B 17459804 1731508 Secretion of the proinflammatory cytokine *requires* caspase-1 and [Toll-like receptor (TLR)] signaling . Positive_regulation TLR10 IL1B 17467812 1737410 [TLR] stimulation of RA-FLS also *induced* the production of and TNF-alpha to a lesser extent ; Positive_regulation TLR10 IL1B 18832719 1971214 A phosphatidylserine species inhibits a range of [TLR-] but not *induced* inflammatory responses by disruption of membrane microdomains . Positive_regulation TLR10 IL1B 20200276 2229584 Caspase-1 independent production is critical for host resistance to mycobacterium tuberculosis and does not *require* [TLR] signaling in vivo . Positive_regulation TLR10 SELL 23573259 2768085 [Toll-Like Receptor] *induced* CD11b and response in patients with coronary artery disease . Positive_regulation TLR10 TNF 12133979 967103 Moreover , various [TLR] ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* NF-kappa B activation and up-regulated production in osteoclast precursor cells . Positive_regulation TLR10 TNF 16847431 1600291 Etanercept , a humanized soluble recombinant p75 TNF-receptor/IgG ( 1 ) Fc fusionprotein , neutralized synergistic CXCL9 production *induced* by plus IFN-gamma , but not synergy between IFN-gamma and the [TLR] ligands PGN or LPS . Positive_regulation TLR10 TNF 17467812 1737409 [TLR] stimulation of RA-FLS also *induced* the production of IL-1beta and to a lesser extent ; Positive_regulation TLR10 TNF 19454685 2084536 [TLR] activation *induces* production from adult neural stem/progenitor cells . Positive_regulation TLR10 TNF 20148136 2208413 Although secretion by adipose cells is probably *induced* , most notably by [TLR] ligands , the activation and secretion pathways of this cytokine are not yet entirely understood . Positive_regulation TLR2 CD14 12443841 1017214 Although and TLR2 mRNA were expressed in cultured NHEK , only [TLR2] was *detected* on the cell surface . Positive_regulation TLR2 CD14 16229899 1489390 However , the pattern recognition receptor (PRR) can also bind PGN and *enhance* [TLR2] mediated signaling in macrophages , suggesting a similar phenomenon might occur in microglia . Positive_regulation TLR2 CD14 23548899 2788981 Similarly , soluble *augmented* the [TLR2/TLR1] response to curli fibers in the absence of membrane bound CD14 . Positive_regulation TLR2 EDN2 18195069 1857036 *activates* [TLR2] independently of TLR1 or TLR6 . Positive_regulation TLR2 EPHB2 17312106 1699612 The [TLR2-BBP] *induced* weak activation of p38 , but not or cytokine mRNA . Positive_regulation TLR2 IL1B 15125785 1252057 Glucocorticoids synergistically enhance *induced* [TLR2] expression via specific up-regulation of the MAP kinase phosphatase-1 that , in turn , leads to dephosphorylation and inactivation of both MAPK JNK and p38 , the negative regulators for TLR2 induction . Positive_regulation TLR2 IL1B 17459804 1731500 Secretion of the proinflammatory cytokine *requires* caspase-1 and [Toll-like receptor (TLR)] signaling . Positive_regulation TLR2 IL1B 17467812 1737386 [TLR] stimulation of RA-FLS also *induced* the production of and TNF-alpha to a lesser extent ; Positive_regulation TLR2 IL1B 18773284 2028345 Combined [TLR2] and NOD2 stimulation *induced* a four-fold higher secretion of TNFalpha and a 13-fold higher secretion of in patients . Positive_regulation TLR2 IL1B 18832719 1971207 A phosphatidylserine species inhibits a range of [TLR-] but not *induced* inflammatory responses by disruption of membrane microdomains . Positive_regulation TLR2 IL1B 19222370 2054426 The transcription of was *induced* through mannose receptor ( MR ) , [Toll-like receptor (TLR) 2] , and dectin-1 but not through TLR4 and TLR9 . Positive_regulation TLR2 IL1B 19474209 2085595 Aspergillus fumigatus keratitis developed in Wistar rats , as evidenced by high SLE scores , influx of polymorphonuclear leukocytes ( PMNs ) , *activation* of [TLR2] and TLR4 , and production of and IL-10 over controls . Positive_regulation TLR2 IL1B 20200276 2229577 Caspase-1 independent production is critical for host resistance to mycobacterium tuberculosis and does not *require* [TLR] signaling in vivo . Positive_regulation TLR2 SELL 23573259 2768071 [Toll-Like Receptor] *induced* CD11b and response in patients with coronary artery disease . Positive_regulation TLR2 SRGN 16551363 1542060 [TLR2] *stimulation* with induces IL-10 and genes associated with T regulatory cells , influenced by maternal atopy . Positive_regulation TLR2 TLR7 16950283 1610277 Expression of [TLR2] , TLR3 , and TLR4 is *regulated* by cytokines and ligands , and their activation mediates chemokine release in ASMCs . Positive_regulation TLR2 TLR7 17617634 1786991 Acylation determines the *dependent* positive versus [TLR2-] , mannose receptor- , and SIGNR1 independent negative regulation of pro-inflammatory cytokines by mycobacterial lipomannan . Positive_regulation TLR2 TLR7 18606009 1935623 Furthermore , Yps3p induced [TLR2] signaling was *suppressed* by vaccinia virus encoded inhibitors . Positive_regulation TLR2 TLR7 19015258 2022491 We showed that Klebsiella induced [TLR2] and TLR4 upregulation was *dependent* on activation . Positive_regulation TLR2 TLR7 19648269 2125487 triggering on tolerogenic dendritic cells *results* in [TLR2] up-regulation and a reduced proinflammatory immune program . Positive_regulation TLR2 TNF 10823826 714882 [TLR-2] synthesis is strongly *induced* in the adipocyte by LPS , , and the yeast cell wall extract zymosan . Positive_regulation TLR2 TNF 11160251 781575 Here we show that LPS , , or IFN-gamma *induce* [TLR2] expression in both human dermal microvessel EC and HUVEC . Positive_regulation TLR2 TNF 11261796 794555 On purified granulocytes , LPS , GM-CSF , and down-regulated , and IL-10 modestly *increased* [TLR2] expression after 2 h . Positive_regulation TLR2 TNF 12133979 967072 Moreover , various [TLR] ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* NF-kappa B activation and up-regulated production in osteoclast precursor cells . Positive_regulation TLR2 TNF 12709026 1083021 The expression of [TLR2] protein by hepatocytes was also remarkably *up-regulated* by IL-1alpha and , to a lesser extent , by as well , but not by LPS or BLP . Positive_regulation TLR2 TNF 12763043 1093836 The results demonstrated three patterns of gene expression : the [TLR2] and myeloid differentiation factor 88 ( MyD88 ) gene expressions were induced in AM in *response* to lipopolysaccharide (LPS) , interleukin (IL)-1beta , or or in the lung tissue of an LPS induced acute lung injury model ; Positive_regulation TLR2 TNF 15345653 1296910 This regulatory mechanism also blocked lipopolysaccharide- and *induced* [TLR2] upregulation in HCAECs and could be important for suppression of other flow-sensitive endothelial proteins . Positive_regulation TLR2 TNF 16008965 1431407 The expressions of CD14 , [TLR2] and TLR9 receptors , which were related with cellular activation , were *up-regulated* by the stimulation of and IFN gamma ( P < 0.05 ) , while SR , which was related with cellular defense action , was down-regulated ( P < 0.05 ) . Positive_regulation TLR2 TNF 16116224 1449066 regulation of *requires* [TLR2/4] for post-transcriptional control , but not for transcriptional induction ; Positive_regulation TLR2 TNF 16847431 1600277 Etanercept , a humanized soluble recombinant p75 TNF-receptor/IgG ( 1 ) Fc fusionprotein , neutralized synergistic CXCL9 production *induced* by plus IFN-gamma , but not synergy between IFN-gamma and the [TLR] ligands PGN or LPS . Positive_regulation TLR2 TNF 16950283 1610269 and double stranded RNA ( dsRNA ; TLR3 ligand ) were potent *inducers* of [TLR2] and TLR3 mRNA expression , and both stimuli had additive or synergistic effects with IFN-gamma on TLR2 and TLR4 , but not TLR3 , mRNA expression . Positive_regulation TLR2 TNF 16950283 1610270 However , dexamethasone potentiated [TLR2] expression *induced* by combined IFN-gamma and stimulation . Positive_regulation TLR2 TNF 17467812 1737385 [TLR] stimulation of RA-FLS also *induced* the production of IL-1beta and to a lesser extent ; Positive_regulation TLR2 TNF 17961202 1815034 *regulates* [Toll-like receptor 2 (TLR2)] expression in microglia . Positive_regulation TLR2 TNF 17961202 1815036 In this study , we demonstrate that the proinflammatory cytokine *enhances* [TLR2] expression in microglia , whereas interleukin-1beta has no significant effect . Positive_regulation TLR2 TNF 17961202 1815037 To determine the downstream signaling events responsible for elevated microglial [TLR2] expression in *response* to , a series of signal transduction inhibitors were employed . Positive_regulation TLR2 TNF 17961202 1815039 Treatment with caffeic acid phenethyl ester , an inhibitor of redox mediated nuclear factor-kappa B activation , significantly attenuated *induced* [TLR2] expression . Positive_regulation TLR2 TNF 18550705 1945932 Mechanical stress *induces* { alpha } production through Ca2+ release dependent [TLR2] signaling . Positive_regulation TLR2 TNF 18550705 1945937 In addition , treatment in THP-1 cells *induced* [TLR2] production in response to mechanical stress , whereas the preincubation of anti-TNF-alpha antibody scarcely induced the mechanical stress mediated production of TLR2 , indicating that TNF-alpha produced by mechanically stimulated THP-1 cells affected TLR2 production . Positive_regulation TLR2 TNF 18768838 1957110 In addition , NF-kappaB inhibitors attenuated *induced* [TLR2] expression in astrocytes . Positive_regulation TLR2 TNF 18773284 2028344 Combined [TLR2] and NOD2 stimulation *induced* a four-fold higher secretion of and a 13-fold higher secretion of IL-1 beta in patients . Positive_regulation TLR2 TNF 19122641 2019502 By activating [TLR2] : TLR6 complexes and *inducing* secretion by myeloid cells , versican strongly enhances LLC metastatic growth . Positive_regulation TLR2 TNF 19410299 2128193 Zymosan *enhanced* [dectin-1/TLR2/TLR4] expression and TNF-alpha/IL-10 production in all of three types of cell , whereas p-beta-glucan increased dectin-1/TLR4 and production in AMs but inhibited IL-10 in mDCs . Positive_regulation TLR2 TNF 19454685 2084519 [TLR] activation *induces* production from adult neural stem/progenitor cells . Positive_regulation TLR2 TNF 19454685 2084539 [TLR2] expression was *increased* by supernatants from activated macrophages and by , which synergized with IFN-gamma . Positive_regulation TLR2 TNF 19570869 2122080 In contrast , iPPVO induced release and enhanced expression of MHC-I and CD86 but not of MHC-II by BMDC chiefly *requires* MyD88 but not [TLR2] or TLR4 . Positive_regulation TLR2 TNF 20148136 2208396 Although secretion by adipose cells is probably *induced* , most notably by [TLR] ligands , the activation and secretion pathways of this cytokine are not yet entirely understood . Positive_regulation TLR2 TNF 20213311 2249199 Treponema denticola suppresses expression of human beta-defensin-2 in gingival epithelial cells through inhibition of production and [TLR2] *activation* . Positive_regulation TLR2 TNF 22402367 2686450 In CMs , [TLR2] and monocyte chemoattractant protein (MCP)-1 mRNAs were *increased* by , PGN or H/R , whereas they were blunted by curcumin . Positive_regulation TLR2 TNF 23233677 2731714 A pneumococcal mutant carrying RrgA with a deletion of the P3 region was significantly reduced in its ability to activate [TLR2] and *induce* responses after mouse intraperitoneal infection , whereas no such difference could be noted when TLR2 ( -/- ) mice were challenged , further implicating this region in recognition by TLR2 . Positive_regulation TLR2 TNF 23333096 2798830 In addition , naringenin suppresses TLR2 expression induced by the co-culture of differentiated adipocytes and macrophages and also inhibits *induced* [TLR2] expression by inhibiting the activation of nuclear factor-?B and c-Jun NH2-terminal kinase pathways in differentiated adipocytes . Positive_regulation TLR2 TNF 24237425 2876283 On the other hand , *increased* TLR1 mRNA ] expression 16-fold , [TLR2] mRNA expression 143- to 201-fold , and TNF-a mRNA expression 131- to 265-fold . Positive_regulation TLR3 CD14 16473828 1523996 Double stranded RNA mediated [TLR3] activation is *enhanced* by . Positive_regulation TLR3 CD14 16473828 1523997 Here , we show that *enhances* double stranded RNA ( dsRNA ) -mediated [Toll-like receptor 3 (TLR3)] activation . Positive_regulation TLR3 CD14 16473828 1523999 Consequently , mediates pIpC uptake and *enhances* [TLR3] signaling . Positive_regulation TLR3 CLU 20692254 2340782 Conclusively , [TLR3] activation *induces* expression of cytoprotective and anti-inflammatory by VSMC and mice , to potentially counteract atherosclerotic pathology . Positive_regulation TLR3 IL1B 15652398 1364185 Quantitative PCR for TLRs 1 to 10 showed a basal expression of [TLR3] that could be *enhanced* by IFN-gamma , , and IFN-beta . Positive_regulation TLR3 IL1B 17459804 1731501 Secretion of the proinflammatory cytokine *requires* caspase-1 and [Toll-like receptor (TLR)] signaling . Positive_regulation TLR3 IL1B 17467812 1737388 [TLR] stimulation of RA-FLS also *induced* the production of and TNF-alpha to a lesser extent ; Positive_regulation TLR3 IL1B 18832719 1971208 A phosphatidylserine species inhibits a range of [TLR-] but not *induced* inflammatory responses by disruption of membrane microdomains . Positive_regulation TLR3 IL1B 20200276 2229578 Caspase-1 independent production is critical for host resistance to mycobacterium tuberculosis and does not *require* [TLR] signaling in vivo . Positive_regulation TLR3 RGS16 15100254 1239582 Engagement of [TLR3] or TLR4 on monocyte derived DCs *induces* and RGS20 , markedly increases RGS1 expression , and potently down-regulates RGS18 and RGS14 without modifying other RGS proteins . Positive_regulation TLR3 SELL 23573259 2768073 [Toll-Like Receptor] *induced* CD11b and response in patients with coronary artery disease . Positive_regulation TLR3 TLR7 16950283 1610287 Expression of TLR2 , [TLR3] , and TLR4 is *regulated* by cytokines and ligands , and their activation mediates chemokine release in ASMCs . Positive_regulation TLR3 TLR7 19769973 2195541 Inhibition of phosphoinositide 3 kinase with LY294002 blocked the up-regulation of PD-L1 by ligands and the [TLR3-specific] *induction* of TRAIL and type 1 IFNs . Positive_regulation TLR3 TLR7 22429150 2624415 Inflammation was mimicked by a cytokine cocktail , and activation was *induced* through [TLR3] and TLR4 ligation . Positive_regulation TLR3 TNF 12133979 967075 Moreover , various [TLR] ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* NF-kappa B activation and up-regulated production in osteoclast precursor cells . Positive_regulation TLR3 TNF 16537619 1536816 IFN-alpha and *induced* the expression of the RIG-I , [TLR3] , MyD88 , TRIF , and IRF7 genes , whereas no detectable TLR7 and TLR8 was seen in A549 cells . Positive_regulation TLR3 TNF 16847431 1600279 Etanercept , a humanized soluble recombinant p75 TNF-receptor/IgG ( 1 ) Fc fusionprotein , neutralized synergistic CXCL9 production *induced* by plus IFN-gamma , but not synergy between IFN-gamma and the [TLR] ligands PGN or LPS . Positive_regulation TLR3 TNF 16954173 1627622 and IFN-gamma *induced* TLR2 , [TLR3] and TLR6 mRNA in mesangial cells , while they down-regulated TLR1-9 mRNA in macrophages . Positive_regulation TLR3 TNF 17196665 1732431 Meanwhile , 24h after poly I:C injection , expression of [TLR3] was markedly elevated within decidua basalis ( DB ) , and endometrial *increased* 2.7-fold but IFN-gamma remained unchanged in homogenized endometrium . Positive_regulation TLR3 TNF 17467812 1737387 [TLR] stimulation of RA-FLS also *induced* the production of IL-1beta and to a lesser extent ; Positive_regulation TLR3 TNF 19454685 2084520 [TLR] activation *induces* production from adult neural stem/progenitor cells . Positive_regulation TLR3 TNF 20148136 2208397 Although secretion by adipose cells is probably *induced* , most notably by [TLR] ligands , the activation and secretion pathways of this cytokine are not yet entirely understood . Positive_regulation TLR4 ADRB2 19167076 2043518 *regulate* [Toll-like receptor 4-induced] late-phase NF-kappaB activation . Positive_regulation TLR4 CD14 11209057 787365 sCD14 mediated cellular activation does not require membrane expression , depends on a region of CD14 that is not involved in lipopolysaccharide binding , and *requires* functional [Toll-like receptor 4] . Positive_regulation TLR4 CD14 12415188 1011259 These results show that [TLR4] in the *presence* of soluble plays a major role in the signaling of LPS in endothelial cells of larger vessels . Positive_regulation TLR4 CD14 14517279 1147332 greatly *enhances* the formation of [LPS-TLR4-MD-2] complexes , but is not coprecipitated with LPS-TLR4-MD-2 complexes , suggesting a role for CD14 in LPS loading onto TLR4-MD-2 but not in the interaction itself between LPS and TLR4-MD-2 . Positive_regulation TLR4 CD14 14597728 1200243 When the effect of lipopolysaccharide contamination is abrogated , Hsp65 is unable to activate [Toll-like receptor (TLR)4] in the *presence* of and MD2 . Positive_regulation TLR4 CD14 14599981 1161398 The expressions of CD14 and [TLR4] in KCs induced by LPS were markedly *increased* in a dose dependent manner ( 10 mg/L-1 microg/L ) or in a time dependent manner ( 0.5 h-24 h ) , with the peaked expression of at 3-6 hours . Positive_regulation TLR4 CD14 17052671 1636287 Similarly , NF-kappa B directed luciferase expression was enhanced by Immulina treatment when cells were co-transfected with vectors expressing proteins supporting TLR2- ( and TLR2 ) but not [TLR4-] ( CD14 , TLR4 , and MD-2 ) dependent *activation* . Positive_regulation TLR4 CD14 17381401 1715484 Assembly and *activation* of the [TLR4] receptor following LPS binding to requires the production of ceramide by acid sphingomyelinase . Positive_regulation TLR4 CD14 18669608 1943244 Our findings suggest that human and bovine RSV may activate human and bovine [TLR4] receptors , respectively , in the *presence* of both MD2 and . Positive_regulation TLR4 CD14 23508573 2787818 We demonstrate that optimal HMGB1 dependent [TLR4] activation in vitro *requires* the coreceptor . Positive_regulation TLR4 CD14 23720457 2811579 IL-8 release induced by Re-LPS , which does not *require* to activate [TLR4] , was insensitive to both bosentan and BQ788 . Positive_regulation TLR4 CLU 24662749 2930606 The results showed that LPS significantly increased MCP-1 and [TLR4] expression and MCP-1 secretion in 3T3-L1 adipocytes , and that the MCP-1 expression was *blocked* by a TLR4 inhibitor ( ) . Positive_regulation TLR4 EPHB2 17403539 1735928 Trauma-hemorrhage increased the production of IL-6 , IL-10 , IL-12 and TNF-alpha enhanced the expression of [TLR4] , MyD88 as well as the *activation* of MAPK proteins ( p38 , and JNK ) in epidermal keratinocytes . Positive_regulation TLR4 EPHB2 20138154 2227172 Hirsutenone , inhibitor or Bay 11-7085 also *prevented* the lipopolysaccharide induced expression of [Toll-like receptor 4] , the phosphorylation of inhibitory kappaB-alpha , the activation of NF-kappaB and the expression of ERK . Positive_regulation TLR4 FAS 15004557 1228057 ligation on macrophages *enhances* [IL-1R1-Toll-like receptor 4] signaling and promotes chronic inflammation . Positive_regulation TLR4 FOXO1 22807038 2719612 A specific PI3K blockade inhibited Akt/ß-catenin signaling , increased *mediated* [TLR4-driven] local inflammation , and recreated cardinal features of liver IR injury . Positive_regulation TLR4 GPR115 20697956 2323050 Tamiflu ( oseltamivir phosphate ) , pertussis toxin (PTX) , a specific inhibitor of Gai proteins of and the broad range inhibitor of matrix metalloproteinase (MMP) galardin applied to live primary BM macrophage cells completely *block* TQ-induced [MyD88/TLR4] complex formation . Positive_regulation TLR4 GPR132 20697956 2323039 Tamiflu ( oseltamivir phosphate ) , pertussis toxin (PTX) , a specific inhibitor of Gai proteins of and the broad range inhibitor of matrix metalloproteinase (MMP) galardin applied to live primary BM macrophage cells completely *block* TQ-induced [MyD88/TLR4] complex formation . Positive_regulation TLR4 GPR87 20697956 2323119 Tamiflu ( oseltamivir phosphate ) , pertussis toxin (PTX) , a specific inhibitor of Gai proteins of and the broad range inhibitor of matrix metalloproteinase (MMP) galardin applied to live primary BM macrophage cells completely *block* TQ-induced [MyD88/TLR4] complex formation . Positive_regulation TLR4 IL1B 10430608 633583 [TLR4] expression levels in cardiac myocytes and in coronary microvascular endothelial cells could be *enhanced* by either LPS or , an effect inhibited by the oxygen radical scavenger PDTC . Positive_regulation TLR4 IL1B 11149903 780431 In contrast to the strong up-regulation of the gene encoding mCD14 during endotoxemia , neither LPS nor *caused* a convincing increase in the [TLR4] mRNA levels across the CNS . Positive_regulation TLR4 IL1B 15509550 1328041 The *role* of in direct and [toll-like receptor 4-mediated] neutrophil activation and survival . Positive_regulation TLR4 IL1B 17459804 1731502 Secretion of the proinflammatory cytokine *requires* caspase-1 and [Toll-like receptor (TLR)] signaling . Positive_regulation TLR4 IL1B 17467812 1737390 [TLR] stimulation of RA-FLS also *induced* the production of and TNF-alpha to a lesser extent ; Positive_regulation TLR4 IL1B 18419766 1944472 Here we show that stimulation of astrocytes with , lipopolysaccharide or ethanol ( 10 and 50 mM ) , *triggers* the translocation of IL-1RI and/or [TLR4] into lipid rafts caveolae enriched fractions , promoting the recruitment of signalling molecules ( phospho-IL-1R associated kinase and phospho-extracellular regulated-kinase ) into these microdomains . Positive_regulation TLR4 IL1B 18832719 1971209 A phosphatidylserine species inhibits a range of [TLR-] but not *induced* inflammatory responses by disruption of membrane microdomains . Positive_regulation TLR4 IL1B 19159824 2027448 Our findings suggest that RAE *induces* [TLR-4] expression and intracellular granzyme-B in treated splenocytes while RAE stimulated , IL-6 , and TNF-alpha in human PBMCs . Positive_regulation TLR4 IL1B 19222370 2054427 The transcription of was *induced* through mannose receptor ( MR ) , Toll-like receptor (TLR) 2 , and dectin-1 but not through [TLR4] and TLR9 . Positive_regulation TLR4 IL1B 19474209 2085597 Aspergillus fumigatus keratitis developed in Wistar rats , as evidenced by high SLE scores , influx of polymorphonuclear leukocytes ( PMNs ) , *activation* of TLR2 and [TLR4] , and production of and IL-10 over controls . Positive_regulation TLR4 IL1B 20067961 2241605 Although both glucose and cream induce NF-kappaB binding and an increase in the expression of SOCS3 , TNF-alpha , and in MNCs , only cream *caused* an increase in LPS concentration and [TLR-4] expression . Positive_regulation TLR4 IL1B 20181058 2222744 potently induced NF-kappaB activation in CaCo-2 cells , but did not *induce* [TLR-4] expression . Positive_regulation TLR4 IL1B 20200276 2229579 Caspase-1 independent production is critical for host resistance to mycobacterium tuberculosis and does not *require* [TLR] signaling in vivo . Positive_regulation TLR4 LBP 16177092 1457957 Activation of the [TLR4] signaling complex *requires* the coordinated function of , CD14 , MD-2 , and TLR4 . Positive_regulation TLR4 LBP 22288713 2575711 The data indicate may *activate* [TLR4] signalling and downstream transcription factor NF-?B , which further can activate STIM1 and eventually lead to calcium influx and injury of HUVECs . Positive_regulation TLR4 PECAM1 18025177 1827641 ligation negatively *regulates* [TLR4] signaling in macrophages . Positive_regulation TLR4 RGS16 15100254 1239584 Engagement of TLR3 or [TLR4] on monocyte derived DCs *induces* and RGS20 , markedly increases RGS1 expression , and potently down-regulates RGS18 and RGS14 without modifying other RGS proteins . Positive_regulation TLR4 SELL 23573259 2768075 [Toll-Like Receptor] *induced* CD11b and response in patients with coronary artery disease . Positive_regulation TLR4 TCN1 23973554 2873376 *increased* the expression of [TLR4] and the EphB1 receptor , the activation of astrocytes and microglial cells , and increased levels of interleukin-1ß (IL-1ß) and tumor necrosis factor-a (TNF-a) . Positive_regulation TLR4 TCN1 23973554 2873384 The administration of EphB2-Fc suppressed the *induced* increase of [TLR4] expression but siRNA2 failed to affect TCI induced EphB1 expression . Positive_regulation TLR4 TLR7 16950283 1610297 Expression of TLR2 , TLR3 , and [TLR4] is *regulated* by cytokines and ligands , and their activation mediates chemokine release in ASMCs . Positive_regulation TLR4 TLR7 19015258 2022501 We showed that Klebsiella induced TLR2 and [TLR4] upregulation was *dependent* on activation . Positive_regulation TLR4 TLR7 22429150 2624425 Inflammation was mimicked by a cytokine cocktail , and activation was *induced* through TLR3 and [TLR4] ligation . Positive_regulation TLR4 TLR7 24595141 2933765 Since stimulation *induced* NF-?B DNA binding activity , [TLR4] expression , and mucosal bacterium killing activity in germfree mice , we conclude that the commensal microflora is critical in maintaining intestinal nondefensin protein expression and the intestinal barrier . Positive_regulation TLR4 TNF 11923281 947221 IFN-gamma regulates MD-2 expression in both IEC lines , whereas IFN-gamma and *regulate* [TLR4] mRNA expression in IEC lines . Positive_regulation TLR4 TNF 12133979 967078 Moreover , various [TLR] ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* NF-kappa B activation and up-regulated production in osteoclast precursor cells . Positive_regulation TLR4 TNF 12923493 1131146 Here , we evaluated [TLR-4] expression of isolated monocytes in the *presence* of , interleukin (IL) 6 , IL-8 , and IL-10 , and we investigated cellular activation of this treatment . Positive_regulation TLR4 TNF 15898987 1408677 These findings indicate that the production of and IL-13 by LPS *required* [TLR4/MyD88/TRAF6] signalling as a common pathway of mast cell mediated inflammation . Positive_regulation TLR4 TNF 16319097 1546933 [TLR4] and MyD88 mRNA and proteins were *induced* by LPS and in RA FLS . Positive_regulation TLR4 TNF 16847431 1600281 Etanercept , a humanized soluble recombinant p75 TNF-receptor/IgG ( 1 ) Fc fusionprotein , neutralized synergistic CXCL9 production *induced* by plus IFN-gamma , but not synergy between IFN-gamma and the [TLR] ligands PGN or LPS . Positive_regulation TLR4 TNF 17015691 1629827 In conclusion , the results of this study suggest that RANTES down-regulates [TLR4] ligation *induced* IL-6 and secretion by enhancing IL-10 production in PB monocytes . Positive_regulation TLR4 TNF 17467812 1737389 [TLR] stimulation of RA-FLS also *induced* the production of IL-1beta and to a lesser extent ; Positive_regulation TLR4 TNF 18000954 1831519 The TLR4 pathway is likely involved , since gp105 activates [TLR4] signaling and *induces* production by monocytes . Positive_regulation TLR4 TNF 18707748 1968087 In conclusion , HTNV infection directly *induces* [TLR4] expression and thereby enhanced production of IFN-beta , IL-6 and , which may contribute to the host 's innate immune response . Positive_regulation TLR4 TNF 19159824 2027447 Our findings suggest that RAE *induces* [TLR-4] expression and intracellular granzyme-B in treated splenocytes while RAE stimulated IL-1beta , IL-6 , and in human PBMCs . Positive_regulation TLR4 TNF 19410299 2128197 Zymosan *enhanced* [dectin-1/TLR2/TLR4] expression and TNF-alpha/IL-10 production in all of three types of cell , whereas p-beta-glucan increased dectin-1/TLR4 and production in AMs but inhibited IL-10 in mDCs . Positive_regulation TLR4 TNF 19454685 2084521 [TLR] activation *induces* production from adult neural stem/progenitor cells . Positive_regulation TLR4 TNF 19650795 2208906 Although the baseline expression of Toll-like receptor (TLR) 4 was low in both HAEC and BAEC , *activated* [TLR4] expression in both cell types . Positive_regulation TLR4 TNF 20148136 2208398 Although secretion by adipose cells is probably *induced* , most notably by [TLR] ligands , the activation and secretion pathways of this cytokine are not yet entirely understood . Positive_regulation TLR4 TNF 20202224 2229656 and Ang II significantly *increased* [TLR4] protein expression . Positive_regulation TLR4 TNF 20540783 2284774 Commensal depletion decreased [TLR4] expression as well as NF-kappaB *activation* of intestine , myeloperoxidase (MPO) activity as well as expression of lung , and bacterial killing activity of peritoneal cells . Positive_regulation TLR4 TNF 20702623 2317639 Rather , we found that MC159 facilitated [Toll-like receptor 4 (TLR4)-] and induced NF-?B *activation* . Positive_regulation TLR4 TNF 21349589 2399582 Stimulation of endothelial monolayers with *resulted* in significant increase of [toll-like receptor 4] , interleukin-6 and -8 , and intercellular adhesion molecule-1 and vascular cellular adhesion molecule-1 gene expression in a time dependent manner . Positive_regulation TLR4 TNF 24084649 2847705 Expression of 4-1bbl depended on early [TLR4] signaling that also *induced* expression , and 4-1BBL translocated to the plasma membrane , where it interacted with TLR4 to mediate late-phase signaling . Positive_regulation TLR5 IL1B 17459804 1731503 Secretion of the proinflammatory cytokine *requires* caspase-1 and [Toll-like receptor (TLR)] signaling . Positive_regulation TLR5 IL1B 17467812 1737392 [TLR] stimulation of RA-FLS also *induced* the production of and TNF-alpha to a lesser extent ; Positive_regulation TLR5 IL1B 18832719 1971210 A phosphatidylserine species inhibits a range of [TLR-] but not *induced* inflammatory responses by disruption of membrane microdomains . Positive_regulation TLR5 IL1B 20200276 2229580 Caspase-1 independent production is critical for host resistance to mycobacterium tuberculosis and does not *require* [TLR] signaling in vivo . Positive_regulation TLR5 SELL 23573259 2768077 [Toll-Like Receptor] *induced* CD11b and response in patients with coronary artery disease . Positive_regulation TLR5 TNF 12133979 967081 Moreover , various [TLR] ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* NF-kappa B activation and up-regulated production in osteoclast precursor cells . Positive_regulation TLR5 TNF 16847431 1600283 Etanercept , a humanized soluble recombinant p75 TNF-receptor/IgG ( 1 ) Fc fusionprotein , neutralized synergistic CXCL9 production *induced* by plus IFN-gamma , but not synergy between IFN-gamma and the [TLR] ligands PGN or LPS . Positive_regulation TLR5 TNF 17467812 1737391 [TLR] stimulation of RA-FLS also *induced* the production of IL-1beta and to a lesser extent ; Positive_regulation TLR5 TNF 19454685 2084522 [TLR] activation *induces* production from adult neural stem/progenitor cells . Positive_regulation TLR5 TNF 20148136 2208399 Although secretion by adipose cells is probably *induced* , most notably by [TLR] ligands , the activation and secretion pathways of this cytokine are not yet entirely understood . Positive_regulation TLR5 TNF 22101519 2514305 Flagellin , IL-13 and all significantly *increased* GAL3ST2 , MUC2 , TFF3 and [TLR5] expression , while only IL-13 increased RETNLB and CHST5 expression . Positive_regulation TLR6 IL1B 17459804 1731509 Secretion of the proinflammatory cytokine *requires* caspase-1 and [Toll-like receptor (TLR)] signaling . Positive_regulation TLR6 IL1B 17467812 1737412 [TLR] stimulation of RA-FLS also *induced* the production of and TNF-alpha to a lesser extent ; Positive_regulation TLR6 IL1B 18832719 1971215 A phosphatidylserine species inhibits a range of [TLR-] but not *induced* inflammatory responses by disruption of membrane microdomains . Positive_regulation TLR6 IL1B 20200276 2229585 Caspase-1 independent production is critical for host resistance to mycobacterium tuberculosis and does not *require* [TLR] signaling in vivo . Positive_regulation TLR6 SELL 23573259 2768087 [Toll-Like Receptor] *induced* CD11b and response in patients with coronary artery disease . Positive_regulation TLR6 TNF 12133979 967106 Moreover , various [TLR] ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* NF-kappa B activation and up-regulated production in osteoclast precursor cells . Positive_regulation TLR6 TNF 16847431 1600293 Etanercept , a humanized soluble recombinant p75 TNF-receptor/IgG ( 1 ) Fc fusionprotein , neutralized synergistic CXCL9 production *induced* by plus IFN-gamma , but not synergy between IFN-gamma and the [TLR] ligands PGN or LPS . Positive_regulation TLR6 TNF 17467812 1737411 [TLR] stimulation of RA-FLS also *induced* the production of IL-1beta and to a lesser extent ; Positive_regulation TLR6 TNF 19454685 2084537 [TLR] activation *induces* production from adult neural stem/progenitor cells . Positive_regulation TLR6 TNF 20148136 2208414 Although secretion by adipose cells is probably *induced* , most notably by [TLR] ligands , the activation and secretion pathways of this cytokine are not yet entirely understood . Positive_regulation TLR7 ADAM11 23794066 2824284 were surprisingly the only human DC that secreted high amounts of IL-12p70 , but they *required* combinational [Toll-like receptor (TLR)] stimulation . Positive_regulation TLR7 ADIPOQ 22535177 2589977 [TLR] activation is mediated by fatty acids and their expression is *regulated* by leptin , and PPARs . Positive_regulation TLR7 AFF1 23878318 2825475 Allergens as immunomodulatory proteins : the cat dander d 1 *enhances* [TLR] activation by lipid ligands . Positive_regulation TLR7 AKT1 19050243 1999297 ZAP70 is induced via *activation* of [TLR-7] or -9 in a MyD88 dependent manner , depends on target of rapamycin signaling and is rapamycin sensitive . Positive_regulation TLR7 ANXA6 16751389 1571026 production in peripheral blood myeloid dendritic cells *required* combined stimulation of [TLR7/8] ligands together with TLR4 or with TLR3 ligands . Positive_regulation TLR7 APCS 18077358 1836857 We report that *activation* of human by [Toll-like receptor ligands (TLR-L)] modulates the lipid biosynthetic pathway , resulting in enhanced recognition of CD1d associated lipids by iNKT cells , as defined by IFN-gamma secretion . Positive_regulation TLR7 APCS 19966212 2190811 This effect is entirely dependent on [TLR7] *activation* of and subsequent IL-6 production . Positive_regulation TLR7 APCS 20980632 2348908 These studies suggest that some age associated immune defects may be overcome by targeted *activation* of by [TLR] ligands . Positive_regulation TLR7 ARRB2 19783052 2163801 These data imply that acts to limit JNK/ERK activation and survival in macrophages , but is *required* for basal and [TLR-inducible] complement C1q expression . Positive_regulation TLR7 ATF1 24470589 2927564 Expression of the 3 ( ATF3 ) gene is *induced* by [Toll-like receptor (TLR)] signaling . Positive_regulation TLR7 ATF2 24470589 2927565 Expression of the 3 ( ATF3 ) gene is *induced* by [Toll-like receptor (TLR)] signaling . Positive_regulation TLR7 ATF3 22347845 2561044 is also *induced* by [Toll-like receptor (TLR)] ligands but acts as a negative regulator of TLR signaling , suppressing the innate immune response which is involved in immuno-surveillance and can enhance or reduce the survival of injured neurons and promote the regeneration of their axons . Positive_regulation TLR7 ATF3 24470589 2927566 Expression of the 3 ( ATF3 ) gene is *induced* by [Toll-like receptor (TLR)] signaling . Positive_regulation TLR7 ATF4 24470589 2927567 Expression of the 3 ( ATF3 ) gene is *induced* by [Toll-like receptor (TLR)] signaling . Positive_regulation TLR7 ATF5 24470589 2927568 Expression of the 3 ( ATF3 ) gene is *induced* by [Toll-like receptor (TLR)] signaling . Positive_regulation TLR7 ATF6 24470589 2927569 Expression of the 3 ( ATF3 ) gene is *induced* by [Toll-like receptor (TLR)] signaling . Positive_regulation TLR7 ATF7 24470589 2927570 Expression of the 3 ( ATF3 ) gene is *induced* by [Toll-like receptor (TLR)] signaling . Positive_regulation TLR7 BCL10 17623099 1787123 The expression profile suggested PI3K/AKT activation and NF-kappaB activation through multiple pathways ( [TLR/IL1R] , TNF receptor induced and TCR-like possibly *involving* ) . Positive_regulation TLR7 BTK 17520285 1857969 Our results do not indicate the essential *role* of in [TLR] signaling and DC development . Positive_regulation TLR7 BTK 18271077 1865797 However , it is not known whether deficiency in XLA might *impair* [TLR] mediated signaling in DCs , which are susceptible to various infections . Positive_regulation TLR7 BTK 18271077 1865828 These findings suggest that may thus be *required* for [TLR] signaling in DCs . Positive_regulation TLR7 BTK 20634142 2316748 Bruton's tyrosine kinase (Btk) has been reported to mediate signaling through toll-like receptors ( TLRs ) in many cell types , however , the *role* of in [TLR] activation of neutrophils remains unclear . Positive_regulation TLR7 BTK 21441935 2417167 Then , interacted with the adaptor molecules MyD88 and TRIF and thereby *promoted* [TLR] signaling . Positive_regulation TLR7 CAMP 19166322 2061101 Correlations between the capacity of LL-37 fragments to modulate TLR responses and their physico-chemical properties revealed that cationicity and hydrophobicity are essential for the modulation of *mediated* [TLR] responses . Positive_regulation TLR7 CAMP 19703986 2133387 In pDC , complexes *activate* [TLR7] and , like self-DNA-LL37 complexes , trigger the secretion of IFN-alpha without inducing maturation or the production of IL-6 and TNF-alpha . Positive_regulation TLR7 CASP1 17360653 1712793 However , we found that Mal was cleaved by caspase-1 and that inhibition of activity *blocked* TLR2- and TLR4 mediated NF-kappaB and p38 MAP kinase activation but not IL-1 or [TLR7] signaling , which are Mal independent . Positive_regulation TLR7 CCL20 24265691 2869801 Expression of is *induced* by [Toll-like Receptor (TLR)] signaling or proinflammatory cytokine stimulation . Positive_regulation TLR7 CCNC 19631980 2131634 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 CD14 21078886 2349633 was *necessary* for [TLR7-] and TLR9 dependent induction of proinflammatory cytokines in vitro and for TLR9 dependent innate immune responses in mice . Positive_regulation TLR7 CD274 18317010 1880995 Upregulation of on monocytes and dendritic cells by HIV-1 *derived* [TLR] ligands . Positive_regulation TLR7 CD274 18317010 1881000 Here we demonstrate that HIV-1 derived [Toll-like receptor (TLR)7/8] ligands can *induce* MyD88 dependent upregulation of on plasmacytoid dendritic cells , myeloidic dendritic cells and monocytes . Positive_regulation TLR7 CD38 19685493 2186215 We report that [TLR] stimulation *induces* expression of , a negative prognostic marker , on B-CLL cells . Positive_regulation TLR7 CD38 19685493 2186230 Expression of CD38 is induced by direct stimulation of B-CLL cells through [TLR-7] and TLR-9 or can be *induced* on B-CLL cells indirectly by a soluble factor induced in non-B-CLL cells after stimulation with TLR-2 , TLR-3 or TLR-5 agonists ; Positive_regulation TLR7 CD44 17277154 1697854 In this study , we examined the *role* of in acute pulmonary inflammation and in the regulation of [LPS-TLR] signaling . Positive_regulation TLR7 CD70 17237405 1689880 In contrast to previous results in vitro , the expression of on dendritic cells in vivo *requires* combined [TLR/CD40] stimulation and is not significantly induced by stimulation of either pathway alone . Positive_regulation TLR7 CD79A 19710454 2133424 Strikingly , both responses required TLR7 signaling , but systemic IgA depended upon TLR7 signaling directly to B cells whereas mucosal *required* [TLR7] signaling to lung dendritic cells and alveolar macrophages . Positive_regulation TLR7 CD93 20861352 2331711 Soluble induces differentiation of monocytes and *enhances* [TLR] responses . Positive_regulation TLR7 CDK19 19631980 2131639 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 CDK8 19631980 2131637 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 CH25H 20699362 2351537 In vitro experiments using a panel of TLR agonists to activate BMDCs and macrophages demonstrated that expression is *induced* rapidly , selectively , and robustly by the [TLR] ligands poly I:C and LPS . Positive_regulation TLR7 CISH 15491991 1347397 Here we have elucidated the nature of the regulatory *role* of in [TLR] signaling . Positive_regulation TLR7 CLEC12A 16239426 1518077 Of interest , ligation *had* the opposite effects on [TLR] versus CD40L signaling : anti-DCAL-2 suppressed TLR induced IL-12 expression , but significantly enhanced CD40L induced IL-12 production . Positive_regulation TLR7 CNPY3 17998391 1826950 We show that a ( PRAT4A ) is *required* for multiple [TLR] responses . Positive_regulation TLR7 CNTN2 17920759 1825210 HTLV-I *enhanced* [TLR] expression and synergistically activated NF-kappaB with wild-type MyD88 . Positive_regulation TLR7 COPS5 21403132 2421271 is *required* for both [Toll-like receptor (TLR)] and reactive oxygen species mediated deneddylation of Cul3 , which is essential for Cul3/Keap1 mediated degradation of nuclear factor E2-related factor 2 . Positive_regulation TLR7 CSF2 18219369 1864098 Of the cytokines examined , IFN-gamma and *caused* the greatest effects on [TLR] expression . Positive_regulation TLR7 CXCR3 16847431 1600249 [TLR] ligands and cytokines *induce* ligands in endothelial cells : enhanced CXCL9 in autoimmune arthritis . Positive_regulation TLR7 DDX58 22945920 2678616 TANK binding kinase 1 (TBK1) plays an essential role in [Toll-like receptor (TLR)-] and mediated *induction* of type I interferon ( IFN ; Positive_regulation TLR7 DOCK2 20231379 2237683 We show that , an atypical Rac activator , is *essential* for [TLR7-] and TLR9 mediated IFN-alpha induction in pDCs . Positive_regulation TLR7 EBI3 15728491 1377281 Thus , gene transcription in DCs is *induced* rapidly by [TLR] signaling during innate immune responses preceding cytokine driven Th cell development . Positive_regulation TLR7 EGFR 18403779 1944254 Our findings identify a novel *dependent* mechanism for regulating [TLR] , and show that targeted disruption of EGFR signaling ameliorates the airway epithelial inflammatory response to pDNA . Positive_regulation TLR7 EPHB2 17507094 1751009 These results suggest that while TRAF6 is absolutely essential for [TLR7] *activation* of , JNK and NF kappa B pathways , TLR4 induced ERK , JNK pathways and IKK mediated phosphorylation of I kappa B family members as well as cytokine expression are differentially sensitive to the cellular levels of TRAF6 . Positive_regulation TLR7 FANCA 24046015 2857376 Reasoning that IL-1ß might be involved in a like autoinhibitory loop , we determined that ( 1 ) [TLR] *activation* of and FANCC-deficient macrophages induced overproduction of both TNF-a and IL-1ß in a p38 dependent manner ; Positive_regulation TLR7 FANCC 24046015 2857377 Reasoning that IL-1ß might be involved in a like autoinhibitory loop , we determined that ( 1 ) [TLR] *activation* of FANCA- and macrophages induced overproduction of both TNF-a and IL-1ß in a p38 dependent manner ; Positive_regulation TLR7 FLT3LG 23685841 2796652 Plasmodium induced release in mice *requires* [Toll-like receptor (TLR)] activation and type I interferon ( IFN ) production . Positive_regulation TLR7 FOXP3 17641056 1771310 We hypothesized that the transcription factor *regulates* the expression of [TLR] family members in human Treg cells . Positive_regulation TLR7 GAB1 20435932 2262601 Grb2 associated binder 1 (Gab1) , a member of scaffolding/adaptor proteins , can mediate signal transduction from many receptors , however , whether and how is *required* for [TLR] and RIG-I triggered innate responses remain unknown . Positive_regulation TLR7 GFI1 20547752 2295906 Here , we analyzed the *role* of the nuclear in the [TLR] response using primary bone marrow derived macrophages . Positive_regulation TLR7 GRK5 22078319 2528419 Together , our results demonstrate multiple *roles* of in [TLR] signaling . Positive_regulation TLR7 HDAC1 23853092 2834829 A hypoxia-inducible factor (HIF) 1 binding site in this promoter was required for *dependent* [TLR-inducible] promoter activity and for Hdac7- and HIF-1a mediated trans-activation . Positive_regulation TLR7 HDAC2 23853092 2834830 A hypoxia-inducible factor (HIF) 1 binding site in this promoter was required for *dependent* [TLR-inducible] promoter activity and for Hdac7- and HIF-1a mediated trans-activation . Positive_regulation TLR7 HDAC7 23853092 2834901 Thus , positively *regulates* HIF-1a dependent [TLR] signaling in macrophages , whereas an interaction with CtBP1 likely prevents Hdac7-s from exerting this effect . Positive_regulation TLR7 HNRNPF 15585847 1345711 We find that the suppressive function of Tregs is critically dependent on immature DCs and is readily reversed by the maturation of DCs induced by GM-CSF , but does not require [TLR] *activation* of either or Tregs . Positive_regulation TLR7 HNRNPF 15585847 1345755 In contrast , reversal of Treg anergy is dependent on [TLR] *activation* of , and involves the potentiation of Treg responsiveness to IL-2 by cooperative effects of IL-6 and IL-1 , both of which are produced by TLR activated , mature DCs . Positive_regulation TLR7 HNRNPF 17041145 1649305 In conclusion , we demonstrate that the anti-microbial peptide LL-37 inhibits the *activation* of by [TLR] ligands . Positive_regulation TLR7 HNRNPF 17414322 1722482 Together , our data suggest that [TLR] ligands *induce* the generation of mature that integrate migratory and cytokine secretory capacity as well as cytotoxic T lymphocyte ( CTL ) stimulatory properties . Positive_regulation TLR7 HNRNPF 17430585 1728885 [TLR] ligand stimulation *induced* capable of secreting IL-12p70 in primary cultures and after one day of coculture with CD40L expressing fibroblasts , mimicking an encounter with T cells . Positive_regulation TLR7 HNRNPF 21330350 2420272 However , the IL-12 family member IL-23 is highly produced upon [TLR] *stimulation* by neonatal . Positive_regulation TLR7 HNRNPF 21493800 2444170 These results suggest that TLR4 and [TLR7/8] signals together *induce* with fully mature and less mature phenotypes that are both required to more efficiently prime CD8+ T cells with qualities associated with memory T cells . Positive_regulation TLR7 HNRNPF 22916243 2657639 Expression of Plexin-B2 and Plexin-D1 is modulated upon *activation* of by [TLR] ligands , TNFa , and anti-CD40 , again in a reciprocal fashion . Positive_regulation TLR7 HNRNPH1 15585847 1345712 We find that the suppressive function of Tregs is critically dependent on immature DCs and is readily reversed by the maturation of DCs induced by GM-CSF , but does not require [TLR] *activation* of either or Tregs . Positive_regulation TLR7 HNRNPH1 15585847 1345756 In contrast , reversal of Treg anergy is dependent on [TLR] *activation* of , and involves the potentiation of Treg responsiveness to IL-2 by cooperative effects of IL-6 and IL-1 , both of which are produced by TLR activated , mature DCs . Positive_regulation TLR7 HNRNPH1 17041145 1649306 In conclusion , we demonstrate that the anti-microbial peptide LL-37 inhibits the *activation* of by [TLR] ligands . Positive_regulation TLR7 HNRNPH1 17414322 1722483 Together , our data suggest that [TLR] ligands *induce* the generation of mature that integrate migratory and cytokine secretory capacity as well as cytotoxic T lymphocyte ( CTL ) stimulatory properties . Positive_regulation TLR7 HNRNPH1 17430585 1728886 [TLR] ligand stimulation *induced* capable of secreting IL-12p70 in primary cultures and after one day of coculture with CD40L expressing fibroblasts , mimicking an encounter with T cells . Positive_regulation TLR7 HNRNPH1 21330350 2420273 However , the IL-12 family member IL-23 is highly produced upon [TLR] *stimulation* by neonatal . Positive_regulation TLR7 HNRNPH1 21493800 2444171 These results suggest that TLR4 and [TLR7/8] signals together *induce* with fully mature and less mature phenotypes that are both required to more efficiently prime CD8+ T cells with qualities associated with memory T cells . Positive_regulation TLR7 HNRNPH1 22916243 2657640 Expression of Plexin-B2 and Plexin-D1 is modulated upon *activation* of by [TLR] ligands , TNFa , and anti-CD40 , again in a reciprocal fashion . Positive_regulation TLR7 HRAS 17045653 1666617 The results demonstrate that for the first time that the small GTPase is *involved* in [TLR] signaling of avian heterophils with the TLR agonists LPS ( Ras ) and FLG ( Rap1 ) inducing differential signaling cascades to activate the downstream ERK MAP kinase . Positive_regulation TLR7 HTRA1 23982886 2855934 LPS and tenascin-C , but not the other [TLR] ligands tested , strongly *induced* expression . Positive_regulation TLR7 IDO1 17725606 1848789 Here we show that the activation of [Toll-like receptors (TLR)-7/8] with isRNAs or R848 , a specific ligand for TLR7/8 , can *induce* expression in human monocytes , but not in monocyte derived dendritic cells ( moDC ) . Positive_regulation TLR7 IFN1@ 19047436 2001648 Collectively , the data demonstrate that TMPD stimulated production *requires* [TLR7/MyD88] signaling and is independent of autoantibody mediated uptake of ribonucleoproteins by FcgammaRs . Positive_regulation TLR7 IFNA1 12045249 950064 and interleukin-12 are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IFNA1 15767370 1384051 Interleukin-1 receptor associated kinase-1 plays an essential role for [Toll-like receptor (TLR)7-] and TLR9 mediated } *induction* . Positive_regulation TLR7 IFNA10 12045249 950065 and interleukin-12 are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IFNA10 15767370 1384052 Interleukin-1 receptor associated kinase-1 plays an essential role for [Toll-like receptor (TLR)7-] and TLR9 mediated } *induction* . Positive_regulation TLR7 IFNA13 12045249 950066 and interleukin-12 are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IFNA13 15767370 1384053 Interleukin-1 receptor associated kinase-1 plays an essential role for [Toll-like receptor (TLR)7-] and TLR9 mediated } *induction* . Positive_regulation TLR7 IFNA14 12045249 950067 and interleukin-12 are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IFNA14 15767370 1384054 Interleukin-1 receptor associated kinase-1 plays an essential role for [Toll-like receptor (TLR)7-] and TLR9 mediated } *induction* . Positive_regulation TLR7 IFNA16 12045249 950068 and interleukin-12 are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IFNA16 15767370 1384055 Interleukin-1 receptor associated kinase-1 plays an essential role for [Toll-like receptor (TLR)7-] and TLR9 mediated } *induction* . Positive_regulation TLR7 IFNA17 12045249 950069 and interleukin-12 are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IFNA17 15767370 1384056 Interleukin-1 receptor associated kinase-1 plays an essential role for [Toll-like receptor (TLR)7-] and TLR9 mediated } *induction* . Positive_regulation TLR7 IFNA2 12045249 950070 and interleukin-12 are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IFNA2 15767370 1384057 Interleukin-1 receptor associated kinase-1 plays an essential role for [Toll-like receptor (TLR)7-] and TLR9 mediated } *induction* . Positive_regulation TLR7 IFNA21 12045249 950071 and interleukin-12 are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IFNA21 15767370 1384058 Interleukin-1 receptor associated kinase-1 plays an essential role for [Toll-like receptor (TLR)7-] and TLR9 mediated } *induction* . Positive_regulation TLR7 IFNA4 12045249 950072 and interleukin-12 are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IFNA4 15767370 1384059 Interleukin-1 receptor associated kinase-1 plays an essential role for [Toll-like receptor (TLR)7-] and TLR9 mediated } *induction* . Positive_regulation TLR7 IFNA5 12045249 950073 and interleukin-12 are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IFNA5 15767370 1384060 Interleukin-1 receptor associated kinase-1 plays an essential role for [Toll-like receptor (TLR)7-] and TLR9 mediated } *induction* . Positive_regulation TLR7 IFNA6 12045249 950074 and interleukin-12 are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IFNA6 15767370 1384061 Interleukin-1 receptor associated kinase-1 plays an essential role for [Toll-like receptor (TLR)7-] and TLR9 mediated } *induction* . Positive_regulation TLR7 IFNA7 12045249 950075 and interleukin-12 are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IFNA7 15767370 1384062 Interleukin-1 receptor associated kinase-1 plays an essential role for [Toll-like receptor (TLR)7-] and TLR9 mediated } *induction* . Positive_regulation TLR7 IFNA8 12045249 950076 and interleukin-12 are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IFNA8 15767370 1384063 Interleukin-1 receptor associated kinase-1 plays an essential role for [Toll-like receptor (TLR)7-] and TLR9 mediated } *induction* . Positive_regulation TLR7 IFNAR1 21911421 2487211 CHIP mediated enhancement of [TLR] signaling is *inhibited* by deficiency or expression of ubiquitination resistant mutant forms of Src or PKC? . Positive_regulation TLR7 IFNB1 12776992 1095478 Meanwhile , TLR3 , [TLR7] , and TLR9 can *induce* both IFN-alpha and . Positive_regulation TLR7 IFNB1 17273997 1697128 These results demonstrate that [TLR] *induce* IFN-alpha or responses by activating distinct IRF , depending on the TLR ligand and the cell type . Positive_regulation TLR7 IFNB1 18025224 1827723 However , the unique induction of by P. gingivalis LPS *requires* [TLR7] and IFNalphabetaR cosignaling , and the induction of ISRE containing gene is dependent on the activation of IFN-beta autocrine loop . Positive_regulation TLR7 IFNB1 19265172 2045527 We found that in vitro treatment of human monocyte derived DCs *induced* the expression of [TLR7] and the members of its downstream signaling pathway , including MyD88 , IL-1R associated kinase 4 , and TNF receptor associated factor 6 , while it inhibited the expression of IL-1R . Positive_regulation TLR7 IFNG 14530316 1149189 Although TLR8 mRNA expression was hardly detectable in freshly isolated eosinophils , mRNA expression of TLR8 as well as [TLR7] was exclusively *up-regulated* by but not by either IL-4 or IL-5 . Positive_regulation TLR7 IFNG 16670286 1558471 The down-regulatory effect of Th2 cytokines on TLR expression and function in IECs also counteracted enhanced [TLR] signaling induced by *stimulation* with the hallmark Th1 cytokine . Positive_regulation TLR7 IFNG 16847431 1600286 Etanercept , a humanized soluble recombinant p75 TNF-receptor/IgG ( 1 ) Fc fusionprotein , neutralized synergistic CXCL9 production *induced* by TNF-alpha plus , but not synergy between IFN-gamma and the [TLR] ligands PGN or LPS . Positive_regulation TLR7 IFNG 18219369 1864099 Of the cytokines examined , and GM-CSF *caused* the greatest effects on [TLR] expression . Positive_regulation TLR7 IFNG 22183805 2591770 Inhibition of [TLR] ligand- and induced murine microglial *activation* by Panax notoginseng . Positive_regulation TLR7 IFNG 22968409 2673526 The results demonstrated that chicken CD4+ and CD8+ T-cells express [TLR21] and that the various isolates of lactobacilli differentially *induces* the expression of interleukin 10 , and transforming growth factor beta . Positive_regulation TLR7 IL10 12045249 950077 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL10 22795952 2645435 Even though [TLR-activation] *induced* TNFa , and IL-6 production , only recombinant TNFa was able to downregulate CD36 . Positive_regulation TLR7 IL10 24737107 2943042 Here , we show that [TLR] signaling , but not BCR activation or CD40 ligation , *induces* potent production of in human B cells . Positive_regulation TLR7 IL11 12045249 950078 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL12A 16751389 1571027 production in peripheral blood myeloid dendritic cells *required* combined stimulation of [TLR7/8] ligands together with TLR4 or with TLR3 ligands . Positive_regulation TLR7 IL12A 20840632 2363794 [TLR7] ligation by small chemical molecules will still *induce* interleukin-6 (IL-6) and tumour necrosis factor-a secretion , but not interferon-a or . Positive_regulation TLR7 IL12B 16751389 1571028 production in peripheral blood myeloid dendritic cells *required* combined stimulation of [TLR7/8] ligands together with TLR4 or with TLR3 ligands . Positive_regulation TLR7 IL12B 20840632 2363795 [TLR7] ligation by small chemical molecules will still *induce* interleukin-6 (IL-6) and tumour necrosis factor-a secretion , but not interferon-a or . Positive_regulation TLR7 IL13 12045249 950079 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL15 12045249 950080 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL15RA 19369481 2089024 Porcine NK cells express both [TLR7] and TLR8 mRNAs , and treatment with these TLR agonists *induced* higher mRNA expression levels of TRAIL and , which may contribute to the activity of NK cells . Positive_regulation TLR7 IL16 12045249 950081 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL18 12045249 950082 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL19 12045249 950083 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL1A 12885415 1116648 MyD88 is an adapter protein that is involved in [Toll-like receptor (TLR)-] and induced *activation* of nuclear factor-kappaB (NF-kappaB) and c-Jun N-terminal kinase (JNK) . Positive_regulation TLR7 IL1A 19819943 2164541 We conclude that FFA and [TLR] stimulation induce proinflammatory factors in islets and that engagement *results* in signal amplification . Positive_regulation TLR7 IL1A 23878142 2865948 production by these cells *requires* [Toll-like receptor (TLR)] and adenosine triphosphate ( ATP ) -mediated P2X purinoceptor 7 (P2X7) signals , which together activate the inflammasome . Positive_regulation TLR7 IL1A 24771848 2937038 In this article , we show that single [TLR] engagement *induces* and , with a little delay , IL-1Ra . Positive_regulation TLR7 IL1B 17459804 1731505 Secretion of the proinflammatory cytokine *requires* caspase-1 and [Toll-like receptor (TLR)] signaling . Positive_regulation TLR7 IL1B 17467812 1737404 [TLR] stimulation of RA-FLS also *induced* the production of and TNF-alpha to a lesser extent ; Positive_regulation TLR7 IL1B 18832719 1971211 A phosphatidylserine species inhibits a range of [TLR-] but not *induced* inflammatory responses by disruption of membrane microdomains . Positive_regulation TLR7 IL1B 20200276 2229581 Caspase-1 independent production is critical for host resistance to mycobacterium tuberculosis and does not *require* [TLR] signaling in vivo . Positive_regulation TLR7 IL2 12045249 950084 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL20 12045249 950085 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL21 12045249 950086 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL22 12045249 950056 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL24 12045249 950054 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL25 12045249 950055 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL26 12045249 950060 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL27 12045249 950061 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL2RA 15096475 1244264 Both [TLR-ligands] and inflammatory cytokines *induced* the expression of , CD69 , CD80 and , surprisingly , also of CD83 , commonly regarded as an activation marker for mature dendritic cells ( DC ) . Positive_regulation TLR7 IL3 12045249 950087 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL31 12045249 950062 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL32 12045249 950059 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL33 12045249 950058 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL34 12045249 950063 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL37 12045249 950057 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL4 12045249 950088 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL4 14530316 1149190 Although TLR8 mRNA expression was hardly detectable in freshly isolated eosinophils , mRNA expression of TLR8 as well as [TLR7] was exclusively *up-regulated* by IFN-gamma but not by either or IL-5 . Positive_regulation TLR7 IL5 12045249 950089 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL5 14530316 1149191 Although TLR8 mRNA expression was hardly detectable in freshly isolated eosinophils , mRNA expression of TLR8 as well as [TLR7] was exclusively *up-regulated* by IFN-gamma but not by either IL-4 or . Positive_regulation TLR7 IL6 12045249 950090 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL6 20840632 2363796 [TLR7] ligation by small chemical molecules will still *induce* and tumour necrosis factor-a secretion , but not interferon-a or IL-12 . Positive_regulation TLR7 IL6 22795952 2645436 Even though [TLR-activation] *induced* TNFa , IL-10 and production , only recombinant TNFa was able to downregulate CD36 . Positive_regulation TLR7 IL6 23843519 2816469 In cultured neurons , [TLR7] activation *induced* and TNF-a expression through Myd88 . Positive_regulation TLR7 IL7 12045249 950091 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL8 12045249 950092 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IL8 18375743 1912945 We conclude that multiple [TLR] ligands *induce* airway epithelial cell production of and VEGF via a Duox1 -- > ROS -- > TACE -- > TGF-alpha -- > EGFR phosphorylation pathway . Positive_regulation TLR7 IL8 19786303 2163894 Collectively , these results suggest that flagellin induced expression *requires* formation of lipid rafts , intracellular [TLR] activation , and subsequent activation of PKC and MAP kinases leading to the activation of the transcription factors NF-kappaB and NF-IL6 in human alveolar type II epithelial cells . Positive_regulation TLR7 IL9 12045249 950093 Interferon-alpha and are *induced* differentially by [Toll-like receptor 7] ligands in human blood dendritic cell subsets . Positive_regulation TLR7 IRAK1 11923871 929837 However , the physiological functions of the IRAK molecules remain unclear , and gene targeting studies have shown that is only partially *required* for IL-1R and [TLR] signalling . Positive_regulation TLR7 IRAK1 22093333 2509230 Primary BECs from explanted PSC livers showed reversibly increased [TLR] and NOD protein expression and *activation* of the signalling complex . Positive_regulation TLR7 IRAK2 21606490 2450159 Thus IRAK-2 in mice and humans may function differently , and therefore we analyzed the *role* of in [TLR] responses in primary human cells . Positive_regulation TLR7 IRAK2 21606490 2450218 Collectively , these data demonstrate for the first time an essential *role* for in primary human cells for both transcriptional and post-transcriptional [TLR] responses . Positive_regulation TLR7 IRAK2 22093333 2509231 Primary BECs from explanted PSC livers showed reversibly increased [TLR] and NOD protein expression and *activation* of the signalling complex . Positive_regulation TLR7 IRAK3 12150927 970897 Thus , *regulates* [TLR] signaling and innate immune homeostasis . Positive_regulation TLR7 IRAK3 14660668 1202299 It was recently reported that negatively *regulates* [TLR] signaling . Positive_regulation TLR7 IRAK3 20817880 2325102 We found that is *induced* in DCs by [TLR] ligation and that its absence from these cells leads to increased activation of the p38-MAPK and NF-?B pathways , which , in turn , improves DC migration to lymph nodes , increases their longevity , and augments their secretion of Th1 skewing cytokines and chemokines . Positive_regulation TLR7 IRAK3 22093333 2509228 Primary BECs from explanted PSC livers showed reversibly increased [TLR] and NOD protein expression and *activation* of the signalling complex . Positive_regulation TLR7 IRAK3 22154382 2563075 ( IRAK-M ) negatively *regulates* [TLR] signaling . Positive_regulation TLR7 IRAK4 17337443 1726634 kinase activity is *required* for interleukin-1 (IL-1) receptor- and [toll-like receptor 7-mediated] signaling and gene expression . Positive_regulation TLR7 IRAK4 22093333 2509229 Primary BECs from explanted PSC livers showed reversibly increased [TLR] and NOD protein expression and *activation* of the signalling complex . Positive_regulation TLR7 IRAK4 23209321 2718423 is *critical* for MyD88 dependent [TLR] signaling , and patients with Irak4 mutations are extremely susceptible to recurrent bacterial infections . Positive_regulation TLR7 IRAK4 23209321 2718438 Importantly , we identified two kinases downstream of the MAPKs , MNK1 and MSK1 , whose phosphorylation is deficient in IRAK4 ( KDKI ) macrophages stimulated through either TLR2 or TLR4 , suggesting that *contributes* to [TLR] signaling beyond the initial phosphorylation of MAPKs . Positive_regulation TLR7 IRAK4 23255009 2709044 Mouse [TLR-] and IL-1R dependent immunity *mediated* by MyD88 and seems to be vital to combat a wide array of experimentally administered pathogens at most ages . Positive_regulation TLR7 IRAK4 23255009 2709064 By contrast , human [TLR-] and IL-1R dependent immunity *mediated* by MyD88 and seems to be effective in the natural setting against only a few bacteria and is most important in infancy and early childhood . Positive_regulation TLR7 IRF1 17059692 1637126 Given that IRF-1 and IRF-2 counter-regulate the transcriptional activity of many genes , we hypothesized that and IRF-2 might also *regulate* [TLR] gene expression following LPS stimulation of murine macrophages . Positive_regulation TLR7 IRF1 17475848 1738452 The induction of [TLR7] in maturing DC was mainly a *consequence* of the transcriptional activity of , whose binding site was located within TLR7 promoter . Positive_regulation TLR7 IRF2 17059692 1637127 Given that IRF-1 and IRF-2 counter-regulate the transcriptional activity of many genes , we hypothesized that IRF-1 and might also *regulate* [TLR] gene expression following LPS stimulation of murine macrophages . Positive_regulation TLR7 IRF4 16243976 1476874 These results imply that negatively *regulates* [TLR] signaling and is inhibitory to the production of proinflammatory cytokines in response to TLR stimulation . Positive_regulation TLR7 IRF5 15695821 1395584 Here we show that in contrast to IRF3 and IRF7 , is not a target of the TLR3 signaling pathway but is *activated* by [TLR7] or TLR8 signaling . Positive_regulation TLR7 IRF7 21435390 2438425 These data provide evidence that cigarette smoke suppresses key pDC functions upon viral infection by a mechanism that involves downregulation of [TLR7] expression and decreased *activation* of . Positive_regulation TLR7 IRF7 22952664 2667448 We find that [TLR7] activation increases the expression of EBV LMP1 , and is *involved* in the stimulation process . Positive_regulation TLR7 IRF9 18340381 1892110 and STAT1 are *required* for IgG autoantibody production and B cell expression of [TLR7] in mice . Positive_regulation TLR7 ITGAM 23573259 2768080 [Toll-Like Receptor] *induced* and L-selectin response in patients with coronary artery disease . Positive_regulation TLR7 JUN 16378096 1512564 Tumor necrosis factor receptor associated factor 6 ( TRAF6 ) is critical for mediating [Toll-like receptor (TLR)-interleukin] 1 receptor (IL-1R) signaling and subsequent *activation* of NF-kappaB and , transcriptional activators of innate immunity . Positive_regulation TLR7 KRAS 17045653 1666618 The results demonstrate that for the first time that the small GTPase is *involved* in [TLR] signaling of avian heterophils with the TLR agonists LPS ( Ras ) and FLG ( Rap1 ) inducing differential signaling cascades to activate the downstream ERK MAP kinase . Positive_regulation TLR7 LTA 15879147 1406078 In this study we examined the *role* of from GBS in phagocyte activation and the requirements for [TLR-LTA] interaction . Positive_regulation TLR7 LTA 20303182 2273048 The aim of the present study was to gain better insight into the nature of the ligand for TLR15 by characterizing gene expression patterns of [TLR15] by heterophils in *response* to numerous bacterial derived TLR agonists LPS , flagellin , CpG oligodeoxynucleotides , , peptidoglycan ( PGN ) , and Pam3CSK4 (PAM) , stimulation with live Salmonella enterica serovar Enteritidis ( SE-used as a positive control ) , chicken isolates of Escherichia coli ( EC ) and Enterococcus gallinarum ( EG ) , the equine-specific pathogen Rhodococcus equi , and stimulation with heat killed , and formalin killed SE , EC , and EG . Positive_regulation TLR7 LYN 20385881 2262022 We demonstrate in this study that the Src family kinase negatively *regulates* [TLR] signaling in murine bone marrow derived macrophages ( BMM Phis ) and in vivo . Positive_regulation TLR7 MAP1LC3A 23831471 2824906 This suppressive effect of Atg5 may not be associated with autophagic processes because MyD88 itself was not degraded and because [TLR] stimulation did not *induce* punctate formation and LC3 conversion . Positive_regulation TLR7 MAP3K7 21335610 2443356 In this study , we sought to determine the *role* of the MAP3K in cytokine and [TLR] mediated signalling . Positive_regulation TLR7 MAPK1 17403539 1735864 Inflammatory mediators , [Toll-like receptor (TLR)] and myeloid differentiation adaptor protein ( MyD88 ) expression , and the *activation* of were determined . Positive_regulation TLR7 MAPK1 23310953 2752729 ß ( 2 ) integrins *inhibit* [TLR] responses by regulating NF-?B pathway and p38 activation . Positive_regulation TLR7 MAPK10 17403539 1735865 Inflammatory mediators , [Toll-like receptor (TLR)] and myeloid differentiation adaptor protein ( MyD88 ) expression , and the *activation* of were determined . Positive_regulation TLR7 MAPK10 23310953 2752730 ß ( 2 ) integrins *inhibit* [TLR] responses by regulating NF-?B pathway and p38 activation . Positive_regulation TLR7 MAPK11 17403539 1735866 Inflammatory mediators , [Toll-like receptor (TLR)] and myeloid differentiation adaptor protein ( MyD88 ) expression , and the *activation* of were determined . Positive_regulation TLR7 MAPK11 23310953 2752731 ß ( 2 ) integrins *inhibit* [TLR] responses by regulating NF-?B pathway and p38 activation . Positive_regulation TLR7 MAPK12 17403539 1735867 Inflammatory mediators , [Toll-like receptor (TLR)] and myeloid differentiation adaptor protein ( MyD88 ) expression , and the *activation* of were determined . Positive_regulation TLR7 MAPK12 23310953 2752732 ß ( 2 ) integrins *inhibit* [TLR] responses by regulating NF-?B pathway and p38 activation . Positive_regulation TLR7 MAPK13 17403539 1735868 Inflammatory mediators , [Toll-like receptor (TLR)] and myeloid differentiation adaptor protein ( MyD88 ) expression , and the *activation* of were determined . Positive_regulation TLR7 MAPK13 23310953 2752733 ß ( 2 ) integrins *inhibit* [TLR] responses by regulating NF-?B pathway and p38 activation . Positive_regulation TLR7 MAPK14 17403539 1735869 Inflammatory mediators , [Toll-like receptor (TLR)] and myeloid differentiation adaptor protein ( MyD88 ) expression , and the *activation* of were determined . Positive_regulation TLR7 MAPK14 23310953 2752734 ß ( 2 ) integrins *inhibit* [TLR] responses by regulating NF-?B pathway and p38 activation . Positive_regulation TLR7 MAPK15 17403539 1735863 Inflammatory mediators , [Toll-like receptor (TLR)] and myeloid differentiation adaptor protein ( MyD88 ) expression , and the *activation* of were determined . Positive_regulation TLR7 MAPK15 23310953 2752728 ß ( 2 ) integrins *inhibit* [TLR] responses by regulating NF-?B pathway and p38 activation . Positive_regulation TLR7 MAPK3 17403539 1735870 Inflammatory mediators , [Toll-like receptor (TLR)] and myeloid differentiation adaptor protein ( MyD88 ) expression , and the *activation* of were determined . Positive_regulation TLR7 MAPK3 23310953 2752735 ß ( 2 ) integrins *inhibit* [TLR] responses by regulating NF-?B pathway and p38 activation . Positive_regulation TLR7 MAPK4 17403539 1735871 Inflammatory mediators , [Toll-like receptor (TLR)] and myeloid differentiation adaptor protein ( MyD88 ) expression , and the *activation* of were determined . Positive_regulation TLR7 MAPK4 23310953 2752736 ß ( 2 ) integrins *inhibit* [TLR] responses by regulating NF-?B pathway and p38 activation . Positive_regulation TLR7 MAPK6 17403539 1735872 Inflammatory mediators , [Toll-like receptor (TLR)] and myeloid differentiation adaptor protein ( MyD88 ) expression , and the *activation* of were determined . Positive_regulation TLR7 MAPK6 23310953 2752737 ß ( 2 ) integrins *inhibit* [TLR] responses by regulating NF-?B pathway and p38 activation . Positive_regulation TLR7 MAPK7 17403539 1735873 Inflammatory mediators , [Toll-like receptor (TLR)] and myeloid differentiation adaptor protein ( MyD88 ) expression , and the *activation* of were determined . Positive_regulation TLR7 MAPK7 23310953 2752738 ß ( 2 ) integrins *inhibit* [TLR] responses by regulating NF-?B pathway and p38 activation . Positive_regulation TLR7 MAPK8 17403539 1735874 Inflammatory mediators , [Toll-like receptor (TLR)] and myeloid differentiation adaptor protein ( MyD88 ) expression , and the *activation* of were determined . Positive_regulation TLR7 MAPK8 23310953 2752739 ß ( 2 ) integrins *inhibit* [TLR] responses by regulating NF-?B pathway and p38 activation . Positive_regulation TLR7 MAPK9 17403539 1735875 Inflammatory mediators , [Toll-like receptor (TLR)] and myeloid differentiation adaptor protein ( MyD88 ) expression , and the *activation* of were determined . Positive_regulation TLR7 MAPK9 23310953 2752740 ß ( 2 ) integrins *inhibit* [TLR] responses by regulating NF-?B pathway and p38 activation . Positive_regulation TLR7 MAVS 22105994 2529738 is *required* for B cell expression of [TLR7] . Positive_regulation TLR7 MED1 18403024 1913802 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED1 19631980 2131661 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED10 18403024 1913797 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED10 19631980 2131657 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED11 18403024 1913800 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED11 19631980 2131660 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED12 19631980 2131632 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED13 18403024 1913784 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED13 19631980 2131642 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED13L 18403024 1913785 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED13L 19631980 2131643 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED14 18403024 1913789 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED14 19631980 2131647 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED15 18403024 1913778 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED15 19631980 2131633 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED16 18403024 1913780 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED16 19631980 2131636 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED17 18403024 1913791 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED17 19631980 2131649 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED18 18403024 1913796 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED18 19631980 2131656 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED19 18403024 1913799 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED19 19631980 2131659 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED20 18403024 1913779 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED20 19631980 2131635 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED21 18403024 1913776 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED21 19631980 2131630 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED22 18403024 1913777 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED22 19631980 2131631 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED23 18403024 1913790 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED23 19631980 2131648 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED24 18403024 1913786 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED24 19631980 2131644 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED25 18403024 1913798 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED25 19631980 2131658 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED26 18403024 1913792 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED26 19631980 2131650 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED27 18403024 1913793 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED27 19631980 2131651 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED28 19631980 2131654 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED29 18403024 1913788 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED29 19631980 2131646 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED30 18403024 1913787 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED30 19631980 2131645 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED31 18403024 1913795 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED31 19631980 2131653 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED4 18403024 1913781 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED4 19631980 2131638 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED6 18403024 1913782 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED6 19631980 2131640 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED7 18403024 1913794 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED7 19631980 2131652 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED8 18403024 1913783 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 MED8 19631980 2131641 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MED9 19631980 2131655 Therefore , we tested the hypothesis that [TLR] stimulation of a trophoblast cell line *induces* inflammatory production and , in particular , production of the preeclampsia related anti-angiogenic factor sFLT-1 . Positive_regulation TLR7 MKS1 17906627 1812444 Here we sought to determine which are *required* for acute [TLR-driven] , MAPK dependent DC endocytic responses . Positive_regulation TLR7 MMP9 23827939 2834613 Tamiflu , specific inhibitor , neuromedin B receptor specific antagonist BIM23127 , and the selective inhibitor of whole heterotrimeric G-protein complex BIM-46174 significantly *block* nucleic acid induced [TLR-7] and -9 MyD88 recruitment , NF-?B activation and proinflammatory TNFa and MCP-1 cytokine responses . Positive_regulation TLR7 MS4A8 22806454 2692047 Innate immunity in these infections is modulated by [Toll-like receptor (TLR)] signaling and TLR2/4/7 agonists strongly *induced* expression in bone marrow derived macrophages ( BMDMs ) treated with M2 mediators ( glucocorticoids/IL-4 ) . Positive_regulation TLR7 MTOR 19050243 1999298 ZAP70 is induced via *activation* of [TLR-7] or -9 in a MyD88 dependent manner , depends on protein kinase B <(PKB)/mammalian target of rapamycin> signaling and is rapamycin sensitive . Positive_regulation TLR7 MUC1 24693944 2949291 In the present study , we determined whether *regulates* MyD88 independent [TLR] signaling mediated through the TLR3-Toll/IL-1 receptor-domain containing adapter inducing IFN-ß ( TRIF ) pathway in response to poly ( I:C ) . Positive_regulation TLR7 MYD88 14971048 1209430 CpG oligodeoxynucleotide induced IL-12p40 and TNF-alpha production , another *dependent* [TLR] mediated signal , was also suppressed by C1q treatment . Positive_regulation TLR7 MYD88 15196129 1260293 Hence , *dependent* [TLR] signalling does not appear to be a crucial component of acute cellular xenograft rejection . Positive_regulation TLR7 MYD88 16272344 1479466 is *involved* in [TLR] , but also in IL-1R associated kinase 1-mediated IL-1R and -18R signaling . Positive_regulation TLR7 MYD88 17114424 1651420 *dependent* [TLR] signals ( TLR4 , 7 , 9 ligation ) , Toll/IL-1 receptor domain containing adaptor dependent TLR signals ( TLR3 , 4 ligation ) as well as non-TLR signals ( CD40 ligation ) induced macrophages and myeloid DC to produce IL-10 in addition to proinflammatory cytokines . Positive_regulation TLR7 MYD88 17145958 1661520 The extensions in the terminal ileum markedly increased upon the introduction of invasive or noninvasive Salmonella organisms , and chimeric mouse studies revealed the key role of *dependent* [Toll-like receptor (TLR)] signaling by nonhematopoietic ( epithelial ) elements in the DC extension response . Positive_regulation TLR7 MYD88 17486091 1744295 A critical function for the carboxy-terminal peptide of ESAT-6 in restricting *dependent* [TLR] signaling emphasizes the possibility that mimetic inhibitory peptides could be used to restrict innate immune responses in situations in which prolonged TLR signaling has deleterious effects . Positive_regulation TLR7 MYD88 17513769 1745787 DCs lacking MyD88 can also form endolysosomal tubules , demonstrating that dependent [TLR] *activation* is not necessary for the formation of this compartment . Positive_regulation TLR7 MYD88 17579078 1763885 [TLR] signaling *mediated* by is required for a protective innate immune response by neutrophils to Citrobacter rodentium . Positive_regulation TLR7 MYD88 17631139 1770397 The adaptor protein *mediates* [Toll-like receptor (TLR)] , interleukin (IL)-1 , and IL-18 signaling . Positive_regulation TLR7 MYD88 17727629 1822449 Importantly , fenofibrate suppression of EAE was associated with decreased expression of IL-12 family cytokine mRNAs as well as mRNAs encoding TLR4 , CD14 , and MyD88 known to play critical roles in *dependent* [TLR] signaling . Positive_regulation TLR7 MYD88 18317010 1881001 Here we demonstrate that HIV-1 derived [Toll-like receptor (TLR)7/8] ligands can *induce* dependent upregulation of PD-L1 on plasmacytoid dendritic cells , myeloidic dendritic cells and monocytes . Positive_regulation TLR7 MYD88 18426885 1926310 however , the IL-8 response was independent of *dependent* [TLR] signaling . Positive_regulation TLR7 MYD88 18581201 1966035 In this study , we sought to determine whether [TLR] signaling is *dependent* on in hASCs . Positive_regulation TLR7 MYD88 19075245 2003077 We found that Paneth cells directly sense enteric bacteria through cell-autonomous dependent [toll-like receptor (TLR)] *activation* , triggering expression of multiple antimicrobial factors . Positive_regulation TLR7 MYD88 19538513 2103598 Thalidomide significantly inhibited the NO production in response to Pam ( 3 ) Cys , CpG DNA and imiquimod as *dependent* [Toll-like receptor (TLR)] ligands , but not polyI : C as a MyD88 independent TLR ligand . Positive_regulation TLR7 MYD88 19559490 2117241 Synergy of TRIF dependent TLR3 and *dependent* [TLR7] in up-regulating expression of mouse FPR2 , a promiscuous G-protein coupled receptor , in microglial cells . Positive_regulation TLR7 MYD88 19898473 2188868 Degradative ubiquitination of TRAF3 during *dependent* [TLR] signaling was essential for the activation of mitogen activated protein kinases ( MAPKs ) and production of inflammatory cytokines . Positive_regulation TLR7 MYD88 19941004 2198859 Here , we investigated the role of [TLR] *activation* by using mice deficient for the common TLR adaptor protein myeloid differentiation factor 88 ( ) on local and remote inflammation following intestinal ischemia . Positive_regulation TLR7 MYD88 19950169 2203945 PKC-alpha controls *dependent* [TLR/IL-1R] signaling and cytokine production in mouse and human dendritic cells . Positive_regulation TLR7 MYD88 19950169 2203956 Conventional PKC ( cPKC ) -alpha regulates TRIF dependent IFN response factor 3 (IRF3) mediated gene transcription , but its role in *dependent* [TLR] signaling remains unknown . Positive_regulation TLR7 MYD88 19950169 2203971 Herein , we demonstrate that PKC-alpha is induced by several *dependent* [TLR/IL-1R] ligands and regulates cytokine expression in human and murine DC . Positive_regulation TLR7 MYD88 20025973 2210873 SIGIRR ( single immunoglobulin interleukin-1 receptor related molecule ) , another member of the TLR/IL-1R superfamily , acts as a negative regulator of *dependent* [TLR] signaling . Positive_regulation TLR7 MYD88 20042589 2200533 We investigated the role of IL-1 receptor associated kinase-M ( IRAK-M ) , an inhibitor of *dependent* [TLR] signaling , in modulating the innate inflammatory response during influenza pneumonia using a murine model . Positive_regulation TLR7 MYD88 20439918 2262729 As IL-1R associated kinase (IRAK)-M is a known inhibitor of *dependent* [IL-1R/TLR] signaling and macrophage function , we sought to determine whether IRAK-M is involved in PGE ( 2 ) -induced immunosuppression post-BMT . Positive_regulation TLR7 MYD88 20702732 2312667 We present a functional analysis of zebrafish Myd88 and Tirap and suggest that Myd88 is more important than Tirap for the activation of Tlr mediated NF-kappaB , which may be a novel mechanism of *dependent* [TLR] signaling in teleosts . Positive_regulation TLR7 MYD88 20956347 2343694 This enhanced cross priming in part involves [TLR7-] but not TLR3 mediated sensing of IAV and is entirely *dependent* on and IFN signaling pathways . Positive_regulation TLR7 MYD88 20962088 2365194 Antigen-specific CD8 ( + ) T-lymphocyte responses elicited by these rAd vectors were significantly diminished in MyD88 ( -/- ) mice but not in TRIF ( -/- ) or TLR3 ( -/- ) mice , suggesting the importance of *dependent* [TLR] signaling . Positive_regulation TLR7 MYD88 21047782 2357658 however , after activation of these cells with *dependent* [TLR] ligands , MHC-II ubiquitination is blocked , and MHC-II survival is prolonged . Positive_regulation TLR7 MYD88 21047782 2357678 We now show that DC activation using *dependent* TLR ligands , MyD88 independent [TLR] ligands , and even infection with the intracellular parasite Toxoplasma gondii leads to identical changes in MHC-II expression , ubiquitination , and surface stability , revealing a conserved role for enhanced MHC-II stability after DC activation by different stimuli . Positive_regulation TLR7 MYD88 21078886 2349631 In this study , we show that CD14 ( cluster of differentiation 14 ) constitutively interacts with the *dependent* [TLR7] and TLR9 . Positive_regulation TLR7 MYD88 21115717 2377591 This is still possible after completely abrogating *dependent* [Toll-like receptor (TLR)] signaling in MEC . Positive_regulation TLR7 MYD88 21918197 2491987 Combination of anti-CD180 with various *dependent* [TLR] ligands biased B cell fate because coinjection diminished Ig production , but purified B cells exhibited synergistic proliferation . Positive_regulation TLR7 MYD88 21918197 2492010 Thus , CD180 stimulation induces intrinsic B cell proliferation and differentiation , causing rapid increases in IgG , and integrates *dependent* [TLR] signals to regulate proliferation , cytokine production , and differentiation . Positive_regulation TLR7 MYD88 21949112 2512437 Heterotrimeric Gi/Go proteins modulate endothelial [TLR] signaling independent of the *dependent* pathway . Positive_regulation TLR7 MYD88 21949249 2492584 The negative regulation of the canonical IKKs by the IKK related kinases occurs in both the TRIF- and *dependent* [TLR] pathways , whereas IRF3 phosphorylation is restricted to the TRIF dependent signaling pathway . Positive_regulation TLR7 MYD88 22093333 2509232 Primary BECs from explanted PSC livers showed reversibly increased [TLR] and NOD protein expression and *activation* of the signalling complex . Positive_regulation TLR7 MYD88 22207179 2568893 Induction of toll-like receptor (TLR) 2 , and *dependent* [TLR-] signaling in response to ligand stimulation and bacterial infections in the Indian major carp , mrigal ( Cirrhinus mrigala ) . Positive_regulation TLR7 MYD88 22326848 2580625 MI enhances ox-CaMKII in wild type ( WT ) hearts but not in MyD88 ( -/- ) hearts that are defective in *dependent* [TLR] signaling . Positive_regulation TLR7 MYD88 22661086 2615438 IRAK-M is an inhibitor of *dependent* [TLR] signaling . Positive_regulation TLR7 MYD88 22783275 2627914 These results indicate that higher expression of [TLR] signaling *activation* of both dependent and TRIF dependent pathways are more beneficial to avian heterophil mediated innate immunity and a complicated regulation of downstream adaptors is involved in stronger induction of a TLR mediated innate response in the resistant line A . Positive_regulation TLR7 MYD88 22837203 2671082 *dependent* [toll-like receptor 7] signaling mediates protection from severe Ross River virus induced disease in mice . Positive_regulation TLR7 MYD88 23055935 2685204 Chemokine levels were measured by ELISA and expression of IRAK-1 , a component of *dependent* [TLR] signaling , assessed by immunoblotting . Positive_regulation TLR7 MYD88 23209321 2718424 IRAK4 is critical for *dependent* [TLR] signaling , and patients with Irak4 mutations are extremely susceptible to recurrent bacterial infections . Positive_regulation TLR7 MYD88 23255009 2709045 Mouse [TLR-] and IL-1R dependent immunity *mediated* by and IRAK-4 seems to be vital to combat a wide array of experimentally administered pathogens at most ages . Positive_regulation TLR7 MYD88 23255009 2709065 By contrast , human [TLR-] and IL-1R dependent immunity *mediated* by and IRAK-4 seems to be effective in the natural setting against only a few bacteria and is most important in infancy and early childhood . Positive_regulation TLR7 MYD88 23490990 2782084 Given the central *role* of in [TLR/IL-1R] signaling , we set out different strategies to develop drugs that can block its function . Positive_regulation TLR7 MYD88 23527272 2762014 This study highlights that synergism between CTB and *dependent* [TLR] signals selectively imprints a TI IgA inducing capacity in non-mucosal DCs , explaining how CTB acts as an IgA promoting adjuvant . Positive_regulation TLR7 MYD88 23831471 2824907 This suppressive effect of Atg5 may not be associated with autophagic processes because itself was not degraded and because [TLR] stimulation did not *induce* LC3 punctate formation and LC3 conversion . Positive_regulation TLR7 MYLIP 19721002 2145419 These data demonstrate a negative-feedback loop in which [TLR] stimulation *induces* to prevent excessive inflammatory responses . Positive_regulation TLR7 MYLIP 20852130 2357036 miRNA profiling showed the significantly differential expression of 19 miRNAs in PDCs after [Toll-like receptor 7 (TLR7)] stimulation , among which and miR-155 were the most highly *induced* . Positive_regulation TLR7 MYLIP 22170100 2517984 Astrocyte were *induced* by cytokines and [TLR] ligands with a distinct hierarchy and involved in proinflammatory cytokine gene induction by targeting suppressor of cytokine signaling 1 , a negative regulator of cytokine signaling and potentially other factors . Positive_regulation TLR7 MYLIP 23794009 2909219 We propose a *role* for in [TLR] signalling through a negative feedback mechanism involving the attenuation of NF-?B by down-regulation of IRAK-1 and TRAF-6 . Positive_regulation TLR7 MYLIP 24014244 2856817 Here , we investigated the *role* of in [TLR] pathway regulation in human pDCs . Positive_regulation TLR7 NAALADL1 20462636 2275712 Of the [TLR] ligands examined , lipopolysaccharide (LPS) and poly were the most potent *activators* of MoDCs , inducing the up-regulation of co-stimulatory molecules CD80/86 and the chemokine receptor CCR7 , and production of pro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)alpha . Positive_regulation TLR7 NAALADL1 23090076 2690518 Combined [TLR] *stimulation* with Pam3Cys and Poly enhances Flt3-ligand dendritic cell activation for tumor immunotherapy . Positive_regulation TLR7 NELFCD 21387177 2438222 While physiological levels of interferon-? promote vascular remodeling at the feto-maternal interface , an overshooting cytokine response *requires* a [Toll-like receptor (TLR)] mediated `` danger signal '' such as lipopolysaccharide (LPS) . Positive_regulation TLR7 NELFCD 23030671 2702550 The results suggest that both [TLR] ligands *induce* a mixed and T ( H ) 2-like response , as characterized by the upregulation of both the T(H)1 associated cytokine interferon-? and the T(H)1 inducing cytokine interleukin (IL)-12 , in addition to the T ( H ) 2-associated cytokine IL-4 , and in the case of flagellin , IL-13 as well . Positive_regulation TLR7 NEU1 21873432 2491457 Recently , we reported a novel membrane sialidase controlling mechanism that depends on ligand binding to its TLR to induce mammalian activity , to influence receptor desialylation , and subsequently to *induce* [TLR] receptor activation and the production of nitric oxide and proinflammatory cytokines in dendritic and macrophage cells . Positive_regulation TLR7 NFAT5 25044064 2956729 In mouse peritoneal macrophages and human macrophages , [TLR] ligation also *induced* activation , which was dependent on XO and p38 kinase . Positive_regulation TLR7 NFKB1 12133979 967095 Moreover , various [TLR] ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* activation and up-regulated TNF-alpha production in osteoclast precursor cells . Positive_regulation TLR7 NFKB1 12792852 1097900 After stimulation , [TLR] recruits IL-1R associated kinase via adaptor myeloid differentiation factor 88 ( MyD88 ) and *induces* activation of and mitogen activated protein kinases . Positive_regulation TLR7 NFKB1 15499080 1367049 [TLR] signaling in CEC did not *involve* ( p65 ) activation with the inhibitory p50 form of NF-kappaB predominating in CEC in both the healthy and inflamed colon . Positive_regulation TLR7 NFKB1 16378096 1512565 Tumor necrosis factor receptor associated factor 6 ( TRAF6 ) is critical for mediating [Toll-like receptor (TLR)-interleukin] 1 receptor (IL-1R) signaling and subsequent *activation* of and AP-1 , transcriptional activators of innate immunity . Positive_regulation TLR7 NFKB1 16457754 1522412 The [TLR] activation *induce* the translocation to the nucleus and cytokine secretion . Positive_regulation TLR7 NFKB1 17558906 1753218 The interleukin receptor associated kinase-M ( IRAK-M ) is a *mediated* , negative regulator of [Toll-like receptor (TLR)] signaling . Positive_regulation TLR7 NFKB1 19521662 2108892 Transforming growth factor-beta activated kinase 1 ( TAK1 ) is a serine/threonine protein kinase that is critically involved in the *activation* of by tumor necrosis factor ( TNFalpha ) , interleukin-1beta (IL-1beta) and [TLR] ligands . Positive_regulation TLR7 NFKB1 19719951 2133658 regulates many genes essential for inflammation and immunity and is *activated* by [toll-like receptor (TLR)] . Positive_regulation TLR7 NGF 19844589 2155557 The different *induced* [TLR] response between VKC and healthy-control conjunctival ECs as well as the different cytokine response might reflect a different pattern of cell activation according to the state of VKC . Positive_regulation TLR7 NLRP3 20348425 2244850 Studies with purified V. cholerae hemolysin revealed that toxin stimulated activation was *induced* by [TLR] and nucleotide binding oligomerization domain 1/2 ligand mediated NF-kappaB activation . Positive_regulation TLR7 NR3C2 9017845 405472 Electrical stimulation ( 20-80 microA ) of the *increased* [TLR] from 28.2 +/- 1.9 to 38.1 +/- 2.4 cmH2OL-1 sec-1 ( 24 sites in 19 cats ; p < 0.001 ) . Positive_regulation TLR7 NRAS 17045653 1666619 The results demonstrate that for the first time that the small GTPase is *involved* in [TLR] signaling of avian heterophils with the TLR agonists LPS ( Ras ) and FLG ( Rap1 ) inducing differential signaling cascades to activate the downstream ERK MAP kinase . Positive_regulation TLR7 OPA1 18403024 1913801 In this study we wanted to know whether ligation of [toll-like receptors (TLR)] expressed by dendritic cells would *induce* differential proinflammatory expression and whether these dendritic cells would differentially impact T cell function . Positive_regulation TLR7 PAM 20303182 2273049 The aim of the present study was to gain better insight into the nature of the ligand for TLR15 by characterizing gene expression patterns of [TLR15] by heterophils in *response* to numerous bacterial derived TLR agonists LPS , flagellin , CpG oligodeoxynucleotides , lipotechoic acid (LTA) , peptidoglycan ( PGN ) , and , stimulation with live Salmonella enterica serovar Enteritidis ( SE-used as a positive control ) , chicken isolates of Escherichia coli ( EC ) and Enterococcus gallinarum ( EG ) , the equine-specific pathogen Rhodococcus equi , and stimulation with heat killed , and formalin killed SE , EC , and EG . Positive_regulation TLR7 PAM 23090076 2690519 Combined [TLR] *stimulation* with and Poly I: C enhances Flt3-ligand dendritic cell activation for tumor immunotherapy . Positive_regulation TLR7 PDLIM7 22952664 2667453 Therefore , the aberrant activation of [TLR7] might *induce* expression and LMP1-expression cells may be producing IFNs in lupus patients . Positive_regulation TLR7 PELI1 23603814 2778702 Notably , *regulates* [Toll-like receptor (TLR)] pathway signaling by promoting degradation of TNF receptor associated factor 3 (Traf3) , a potent inhibitor of mitogen activated protein kinase (MAPK) activation and gene induction . Positive_regulation TLR7 PI3 18227218 1871218 has been shown to be *activated* by [TLR] triggering in multiple cell types ; Positive_regulation TLR7 PIK3CA 25015834 2952982 However , the mechanisms by which negatively *regulates* [TLR] signaling are only partially resolved . Positive_regulation TLR7 PIK3R1 25015834 2952983 However , the mechanisms by which negatively *regulates* [TLR] signaling are only partially resolved . Positive_regulation TLR7 POLDIP2 23310953 2752727 ß ( 2 ) integrins *inhibit* [TLR] responses by regulating NF-?B pathway and MAPK activation . Positive_regulation TLR7 PPP3CA 17878357 1796947 Evidence for this novel role for calcineurin was provided by the findings that these signaling pathways are activated when calcineurin is inhibited either by the inhibitors cyclosporin A or FK506 or by small interfering RNA targeting calcineurin , and that activation of these pathways by [TLR] ligands is *inhibited* by the overexpression of a constitutively active form of . Positive_regulation TLR7 PPP3CB 17878357 1796948 Evidence for this novel role for calcineurin was provided by the findings that these signaling pathways are activated when calcineurin is inhibited either by the inhibitors cyclosporin A or FK506 or by small interfering RNA targeting calcineurin , and that activation of these pathways by [TLR] ligands is *inhibited* by the overexpression of a constitutively active form of . Positive_regulation TLR7 PPP3CC 17878357 1796949 Evidence for this novel role for calcineurin was provided by the findings that these signaling pathways are activated when calcineurin is inhibited either by the inhibitors cyclosporin A or FK506 or by small interfering RNA targeting calcineurin , and that activation of these pathways by [TLR] ligands is *inhibited* by the overexpression of a constitutively active form of . Positive_regulation TLR7 PRKCA 19950169 2203972 Herein , we demonstrate that is *induced* by several MyD88 dependent [TLR/IL-1R] ligands and regulates cytokine expression in human and murine DC . Positive_regulation TLR7 PTBP1 15585847 1345713 We find that the suppressive function of Tregs is critically dependent on immature DCs and is readily reversed by the maturation of DCs induced by GM-CSF , but does not require [TLR] *activation* of either or Tregs . Positive_regulation TLR7 PTBP1 15585847 1345757 In contrast , reversal of Treg anergy is dependent on [TLR] *activation* of , and involves the potentiation of Treg responsiveness to IL-2 by cooperative effects of IL-6 and IL-1 , both of which are produced by TLR activated , mature DCs . Positive_regulation TLR7 PTBP1 17041145 1649307 In conclusion , we demonstrate that the anti-microbial peptide LL-37 inhibits the *activation* of by [TLR] ligands . Positive_regulation TLR7 PTBP1 17414322 1722484 Together , our data suggest that [TLR] ligands *induce* the generation of mature that integrate migratory and cytokine secretory capacity as well as cytotoxic T lymphocyte ( CTL ) stimulatory properties . Positive_regulation TLR7 PTBP1 17430585 1728887 [TLR] ligand stimulation *induced* capable of secreting IL-12p70 in primary cultures and after one day of coculture with CD40L expressing fibroblasts , mimicking an encounter with T cells . Positive_regulation TLR7 PTBP1 18403023 1913596 We have analyzed the expression of 10 TLR genes relative to validated reference genes at predilection sites in ileum , jejunum and associated lymph nodes as well as in peripheral blood , to determine if [TLR] expression is altered in *response* to infection with M . in outbred sheep . Positive_regulation TLR7 PTBP1 21330350 2420274 However , the IL-12 family member IL-23 is highly produced upon [TLR] *stimulation* by neonatal . Positive_regulation TLR7 PTBP1 21493800 2444172 These results suggest that TLR4 and [TLR7/8] signals together *induce* with fully mature and less mature phenotypes that are both required to more efficiently prime CD8+ T cells with qualities associated with memory T cells . Positive_regulation TLR7 PTBP1 22916243 2657641 Expression of Plexin-B2 and Plexin-D1 is modulated upon *activation* of by [TLR] ligands , TNFa , and anti-CD40 , again in a reciprocal fashion . Positive_regulation TLR7 PTBP2 15585847 1345710 We find that the suppressive function of Tregs is critically dependent on immature DCs and is readily reversed by the maturation of DCs induced by GM-CSF , but does not require [TLR] *activation* of either or Tregs . Positive_regulation TLR7 PTBP2 15585847 1345754 In contrast , reversal of Treg anergy is dependent on [TLR] *activation* of , and involves the potentiation of Treg responsiveness to IL-2 by cooperative effects of IL-6 and IL-1 , both of which are produced by TLR activated , mature DCs . Positive_regulation TLR7 PTBP2 17041145 1649304 In conclusion , we demonstrate that the anti-microbial peptide LL-37 inhibits the *activation* of by [TLR] ligands . Positive_regulation TLR7 PTBP2 17414322 1722481 Together , our data suggest that [TLR] ligands *induce* the generation of mature that integrate migratory and cytokine secretory capacity as well as cytotoxic T lymphocyte ( CTL ) stimulatory properties . Positive_regulation TLR7 PTBP2 17430585 1728884 [TLR] ligand stimulation *induced* capable of secreting IL-12p70 in primary cultures and after one day of coculture with CD40L expressing fibroblasts , mimicking an encounter with T cells . Positive_regulation TLR7 PTBP2 21330350 2420271 However , the IL-12 family member IL-23 is highly produced upon [TLR] *stimulation* by neonatal . Positive_regulation TLR7 PTBP2 21493800 2444169 These results suggest that TLR4 and [TLR7/8] signals together *induce* with fully mature and less mature phenotypes that are both required to more efficiently prime CD8+ T cells with qualities associated with memory T cells . Positive_regulation TLR7 PTBP2 22916243 2657638 Expression of Plexin-B2 and Plexin-D1 is modulated upon *activation* of by [TLR] ligands , TNFa , and anti-CD40 , again in a reciprocal fashion . Positive_regulation TLR7 PTGS2 20971925 2348640 We hypothesized that is *induced* by [TLR] activation and is necessary for optimal AMP production , and that inhibitors of Cox-2 may therefore inhibit antimicrobial action . Positive_regulation TLR7 PTPN6 18391954 1899310 Phosphatase *promotes* [TLR-] and RIG-I activated production of type I interferon by inhibiting the kinase IRAK1 . Positive_regulation TLR7 PTX3 16461742 1540870 production was *induced* by [TLR] ligands , CD40 ligand , and interleukin (IL)-1beta and was suppressed by dexamethasone , 1alpha , 25-dihydroxivitamin D3 , and prostaglandin E2 . Positive_regulation TLR7 QRICH1 24742067 2939178 *attenuates* the inhibitory effect of methotrexate on [TLR] signaling during intestinal chemotherapy induced mucositis in a rat . Positive_regulation TLR7 QRICH2 24742067 2939179 *attenuates* the inhibitory effect of methotrexate on [TLR] signaling during intestinal chemotherapy induced mucositis in a rat . Positive_regulation TLR7 RBBP4 23853092 2834831 A hypoxia-inducible factor (HIF) 1 binding site in this promoter was required for *dependent* [TLR-inducible] promoter activity and for Hdac7- and HIF-1a mediated trans-activation . Positive_regulation TLR7 RBBP7 23853092 2834832 A hypoxia-inducible factor (HIF) 1 binding site in this promoter was required for *dependent* [TLR-inducible] promoter activity and for Hdac7- and HIF-1a mediated trans-activation . Positive_regulation TLR7 REL 20833375 2319002 The NF-?B member was *essential* for [TLR-] , NOD2- , and NALP3 mediated induction of CD200 . Positive_regulation TLR7 RELA 12133979 967096 Moreover , various [TLR] ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* activation and up-regulated TNF-alpha production in osteoclast precursor cells . Positive_regulation TLR7 RELA 12792852 1097901 After stimulation , [TLR] recruits IL-1R associated kinase via adaptor myeloid differentiation factor 88 ( MyD88 ) and *induces* activation of and mitogen activated protein kinases . Positive_regulation TLR7 RELA 15499080 1367050 [TLR] signaling in CEC did not *involve* ( p65 ) activation with the inhibitory p50 form of NF-kappaB predominating in CEC in both the healthy and inflamed colon . Positive_regulation TLR7 RELA 16378096 1512566 Tumor necrosis factor receptor associated factor 6 ( TRAF6 ) is critical for mediating [Toll-like receptor (TLR)-interleukin] 1 receptor (IL-1R) signaling and subsequent *activation* of and AP-1 , transcriptional activators of innate immunity . Positive_regulation TLR7 RELA 16457754 1522413 The [TLR] activation *induce* the translocation to the nucleus and cytokine secretion . Positive_regulation TLR7 RELA 17558906 1753219 The interleukin receptor associated kinase-M ( IRAK-M ) is a *mediated* , negative regulator of [Toll-like receptor (TLR)] signaling . Positive_regulation TLR7 RELA 19521662 2108893 Transforming growth factor-beta activated kinase 1 ( TAK1 ) is a serine/threonine protein kinase that is critically involved in the *activation* of by tumor necrosis factor ( TNFalpha ) , interleukin-1beta (IL-1beta) and [TLR] ligands . Positive_regulation TLR7 RELA 19719951 2133659 regulates many genes essential for inflammation and immunity and is *activated* by [toll-like receptor (TLR)] . Positive_regulation TLR7 RIPK2 18085666 1847337 contributes to Nod signaling but is not *essential* for T cell proliferation , T helper differentiation or [TLR] responses . Positive_regulation TLR7 RPS6KA1 24277938 2898443 Here , we show that ( S6K1 ) negatively *regulates* [TLR] mediated signals by inhibiting TAK1 activity . Positive_regulation TLR7 RSAD2 21435586 2406470 Antiviral protein *promotes* [Toll-like receptor 7-] and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells . Positive_regulation TLR7 RSAD2 21435586 2406471 We showed that the IFN-inducible antiviral protein *promoted* [TLR7-] and TLR9 mediated production of type I IFN by pDCs . Positive_regulation TLR7 RSAD2 21435586 2406472 Loss of *reduced* [TLR7-] and TLR9 mediated production of type I IFN by pDCs . Positive_regulation TLR7 RSAD2 23189823 2704819 We showed that the IFN-inducible antiviral protein *promoted* [TLR7-] and TLR9 mediated production of type I IFN by pDCs . Positive_regulation TLR7 S100A9 19835955 2164942 ) have recently been characterized as endogenous TLR4-agonists , and thus may *mediate* [TLR-activation] in cerebral ischemia . Positive_regulation TLR7 SELL 23573259 2768079 [Toll-Like Receptor] *induced* CD11b and response in patients with coronary artery disease . Positive_regulation TLR7 SEMA3A 21098092 2357796 [TLR] engagement can *induce* expression , thus completing an autocrine loop . Positive_regulation TLR7 SETD2 23853092 2834902 Thus , Hdac7-u positively regulates *dependent* [TLR] signaling in macrophages , whereas an interaction with CtBP1 likely prevents Hdac7-s from exerting this effect . Positive_regulation TLR7 SFTPA1 18523248 1922704 Pulmonary *regulates* [TLR] expression and activity in human macrophages . Positive_regulation TLR7 SFTPA2 18523248 1922705 Pulmonary *regulates* [TLR] expression and activity in human macrophages . Positive_regulation TLR7 SLC15A4 25238095 2958781 is *required* for [Toll-like receptor 7 (TLR7)-] and TLR9 mediated type I interferon ( IFN-I ) productions in plasmacytoid dendritic cells ( pDCs ) and is involved in the pathogenesis of certain diseases including lupus-like autoimmunity . Positive_regulation TLR7 SNRNP200 16368889 1539746 U1 immune complexes *induce* type I interferon in plasmacytoid dendritic cells through [TLR7] . Positive_regulation TLR7 SNRNP25 16368889 1539741 U1 immune complexes *induce* type I interferon in plasmacytoid dendritic cells through [TLR7] . Positive_regulation TLR7 SNRNP27 16368889 1539743 U1 immune complexes *induce* type I interferon in plasmacytoid dendritic cells through [TLR7] . Positive_regulation TLR7 SNRNP35 16368889 1539744 U1 immune complexes *induce* type I interferon in plasmacytoid dendritic cells through [TLR7] . Positive_regulation TLR7 SNRNP40 16368889 1539745 U1 immune complexes *induce* type I interferon in plasmacytoid dendritic cells through [TLR7] . Positive_regulation TLR7 SNRNP48 16368889 1539742 U1 immune complexes *induce* type I interferon in plasmacytoid dendritic cells through [TLR7] . Positive_regulation TLR7 SNRNP70 16368889 1539740 U1 immune complexes *induce* type I interferon in plasmacytoid dendritic cells through [TLR7] . Positive_regulation TLR7 SOCS1 16896155 1654070 The results indicate that [TLR] stimulation during the period of DC generation interferes with and deviates DC differentiation and that these effects are *mediated* particularly by . Positive_regulation TLR7 STAG2 19124731 2019552 [TLR] *triggering* and NF-kappaB activation by were analyzed on TLR transfected HEK293 cells and on purified bone marrow dendritic cells . Positive_regulation TLR7 STAT1 17785783 1790611 Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells : alternatively activated negatively *regulates* [TLR] signaling in macrophages . Positive_regulation TLR7 STAT1 18340381 1892109 IRF9 and are *required* for IgG autoantibody production and B cell expression of [TLR7] in mice . Positive_regulation TLR7 STAT3 23023703 2706419 Furthermore , [TLR7] ligation *induced* activation and interfaced with Notch as well as canonical NF-?B and MAP kinase pathways , but downregulated expression of Notch target genes . Positive_regulation TLR7 SYK 20138367 2227215 Herein , we investigated the *role* of in [TLR] mediated signaling and gene regulation . Positive_regulation TLR7 TGFB1 22968409 2673523 The results demonstrated that chicken CD4+ and CD8+ T-cells express [TLR21] and that the various isolates of lactobacilli differentially *induces* the expression of interleukin 10 , interferon-gamma and . Positive_regulation TLR7 TGFB2 22968409 2673524 The results demonstrated that chicken CD4+ and CD8+ T-cells express [TLR21] and that the various isolates of lactobacilli differentially *induces* the expression of interleukin 10 , interferon-gamma and . Positive_regulation TLR7 TGFB3 22968409 2673525 The results demonstrated that chicken CD4+ and CD8+ T-cells express [TLR21] and that the various isolates of lactobacilli differentially *induces* the expression of interleukin 10 , interferon-gamma and . Positive_regulation TLR7 TIRAP 24529375 2914922 Here , we report that , in response to natural activators of innate immunity , the sorting adaptor *regulates* [TLR] signaling from the plasma membrane and endosomes . Positive_regulation TLR7 TLR1 17548618 1752357 These data indicate that TLR-3 or [TLR-7] *activation* by viral ligands has both preventive as well as suppressive effects on experimental asthma which is mediated by the additive effects of IL-12 and IL-10 . Positive_regulation TLR7 TLR1 21462502 2412872 By comparing the TLRs transcription between YL040920 and CVI988/Rispens infected microglia , it was suggested that vvMDV YL040920 might *induce* more [TLR15] transcript than the attenuated vaccine strain CVI988/Rispens ( P < or = 0.01/0.001 ) , while CVI988/Rispens induced more transcript than YL040920 ( P < or = 0.001 ) . Positive_regulation TLR7 TLR10 17548618 1752365 These data indicate that TLR-3 or [TLR-7] *activation* by viral ligands has both preventive as well as suppressive effects on experimental asthma which is mediated by the additive effects of IL-12 and IL-10 . Positive_regulation TLR7 TLR2 17548618 1752358 These data indicate that TLR-3 or [TLR-7] *activation* by viral ligands has both preventive as well as suppressive effects on experimental asthma which is mediated by the additive effects of IL-12 and IL-10 . Positive_regulation TLR7 TLR2 22253793 2538396 Moreover , stimulation of the Muller glia with , 3 , 4 , 5 , 7 and 9 agonists *resulted* in an increased [TLR] expression as assayed by Western blot and flow cytometry . Positive_regulation TLR7 TLR2 24551212 2915541 In this study , we use the human TLR reporter monocytic cell line , THP1-Blue , which expresses all human TLRs , to investigate effects of Blastocystis on [TLR] *activation* , more specifically the activation of , -4 and -5 . Positive_regulation TLR7 TLR3 17548618 1752359 These data indicate that TLR-3 or [TLR-7] *activation* by viral ligands has both preventive as well as suppressive effects on experimental asthma which is mediated by the additive effects of IL-12 and IL-10 . Positive_regulation TLR7 TLR3 23232980 2786100 These findings demonstrate that activation differentially *regulates* [TLR] expression through autocrine signaling involving IL-6 secretion , IL-6Ra activation and subsequent phosphorylation of Stat3 . Positive_regulation TLR7 TLR3 23413283 2860773 In cultured human and mouse skin fibroblasts , TSLP expression was inducible by *activation* of [TLR] , particularly . Positive_regulation TLR7 TLR4 12459484 1021754 Co-expression of the alphav-TLR and beta5-TLR chimeras in 293T cells generated 10 [TLR] homodimers , but only could effectively *activate* NF-kappaB . Positive_regulation TLR7 TLR4 17548618 1752360 These data indicate that TLR-3 or [TLR-7] *activation* by viral ligands has both preventive as well as suppressive effects on experimental asthma which is mediated by the additive effects of IL-12 and IL-10 . Positive_regulation TLR7 TLR4 22986631 2720005 The [TLR] signals that regulate the phagocytic ability of macrophages were also *induced* by and TLR5 activation . Positive_regulation TLR7 TLR4 24595141 2933771 Since [TLR] stimulation *induced* NF-?B DNA binding activity , expression , and mucosal bacterium killing activity in germfree mice , we conclude that the commensal microflora is critical in maintaining intestinal nondefensin protein expression and the intestinal barrier . Positive_regulation TLR7 TLR5 17548618 1752361 These data indicate that TLR-3 or [TLR-7] *activation* by viral ligands has both preventive as well as suppressive effects on experimental asthma which is mediated by the additive effects of IL-12 and IL-10 . Positive_regulation TLR7 TLR5 22986631 2720006 The [TLR] signals that regulate the phagocytic ability of macrophages were also *induced* by TLR4 and activation . Positive_regulation TLR7 TLR6 17548618 1752366 These data indicate that TLR-3 or [TLR-7] *activation* by viral ligands has both preventive as well as suppressive effects on experimental asthma which is mediated by the additive effects of IL-12 and IL-10 . Positive_regulation TLR7 TLR7 17548618 1752362 These data indicate that TLR-3 or [TLR-7] *activation* by viral ligands has both preventive as well as suppressive effects on experimental asthma which is mediated by the additive effects of IL-12 and IL-10 . Positive_regulation TLR7 TLR8 17548618 1752363 These data indicate that TLR-3 or [TLR-7] *activation* by viral ligands has both preventive as well as suppressive effects on experimental asthma which is mediated by the additive effects of IL-12 and IL-10 . Positive_regulation TLR7 TLR8 19848448 2160342 [TLR7] expression on antigen presenting cells is *detected* in plasmacytoid dendritic cells , CD34+ derived dendritic cells , and B-cells , whereas is mainly expressed on cells of the myeloid lineage , such as monocytes , macrophages , and myeloid dendritic cells . Positive_regulation TLR7 TLR8 20811154 2330684 These data provide evidence for a pivotal *role* for mouse in the regulation of mouse [TLR7] expression and prevention of spontaneous autoimmunity . Positive_regulation TLR7 TLR9 16436336 1516454 During the allergic reaction , [TLR] engagement on DC directs the polarization of the T cell response and , while TLR2 and TLR4 may favour both Th1 and Th2 responses , *induces* the development of regulatory T cells . Positive_regulation TLR7 TLR9 17548618 1752364 These data indicate that TLR-3 or [TLR-7] *activation* by viral ligands has both preventive as well as suppressive effects on experimental asthma which is mediated by the additive effects of IL-12 and IL-10 . Positive_regulation TLR7 TLR9 19129482 2047892 Role of atopic status in [Toll-like receptor (TLR)7-] and mediated *activation* of human eosinophils . Positive_regulation TLR7 TLR9 20089701 2206069 *regulates* [TLR7-] and MyD88 dependent autoantibody production and disease in a murine model of lupus . Positive_regulation TLR7 TLR9 22434514 2624434 Data from mouse models suggest a pathogenic role for [TLR7] and a protective *role* for in the pathogenesis of SLE . Positive_regulation TLR7 TNF 12133979 967094 Moreover , various [TLR] ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* NF-kappa B activation and up-regulated production in osteoclast precursor cells . Positive_regulation TLR7 TNF 16847431 1600285 Etanercept , a humanized soluble recombinant p75 TNF-receptor/IgG ( 1 ) Fc fusionprotein , neutralized synergistic CXCL9 production *induced* by plus IFN-gamma , but not synergy between IFN-gamma and the [TLR] ligands PGN or LPS . Positive_regulation TLR7 TNF 17467812 1737403 [TLR] stimulation of RA-FLS also *induced* the production of IL-1beta and to a lesser extent ; Positive_regulation TLR7 TNF 19454685 2084533 [TLR] activation *induces* production from adult neural stem/progenitor cells . Positive_regulation TLR7 TNF 20148136 2208410 Although secretion by adipose cells is probably *induced* , most notably by [TLR] ligands , the activation and secretion pathways of this cytokine are not yet entirely understood . Positive_regulation TLR7 TNF 23843519 2816468 In cultured neurons , [TLR7] activation *induced* IL-6 and expression through Myd88 . Positive_regulation TLR7 TNFSF10 19369481 2089023 Porcine NK cells express both [TLR7] and TLR8 mRNAs , and treatment with these TLR agonists *induced* higher mRNA expression levels of and IL-15Ralpha , which may contribute to the activity of NK cells . Positive_regulation TLR7 TNFSF13B 17664289 1776714 Moreover , *enhanced* [TLR7/9] expression on B cells and TLR mediated production of autoantibodies . Positive_regulation TLR7 TOLLIP 15140579 1247149 Our study provides yet another mechanism for suppressing excessive [TLR] signaling activation *mediated* by . Positive_regulation TLR7 TP53 22673234 2643631 The effect of DNA stressors on [TLR] expression was mainly *mediated* by , and several p53 cancer associated mutants dramatically altered the pattern of TLR gene expression . Positive_regulation TLR7 TP53 23150340 2717953 Activation of by common antitumor agents *results* in p53 dependent regulation of expression of most [TLR] genes in human primary and cancer cell lines , resulting in modulation of TLR downstream responses to cognate ligands . Positive_regulation TLR7 TRAF5 24259503 2892710 negatively *regulates* [TLR] signaling in B lymphocytes . Positive_regulation TLR7 TRAF5 24259503 2892750 negatively *regulated* [TLR] signaling in a cell-specific manner , because TRAF5 ( -/- ) macrophages and dendritic cells showed less dramatic differences in TLR mediated cytokine production than B cells . Positive_regulation TLR7 TRAF6 17507094 1750970 Recent studies using macrophages from TRAF6 knockout mice have revealed that is *required* for [TLR7] signaling . Positive_regulation TLR7 TRAF6 17507094 1751008 These results suggest that while is absolutely *essential* for [TLR7] activation of ERK , JNK and NF kappa B pathways , TLR4 induced ERK , JNK pathways and IKK mediated phosphorylation of I kappa B family members as well as cytokine expression are differentially sensitive to the cellular levels of TRAF6 . Positive_regulation TLR7 TRAF6 17579076 1763875 Activation of RAW 264.7 cells by sVSG following treatment of the cells with the TRAF6 inhibitory peptide DIVK resulted in enhanced NF-kappaB signaling , suggesting both that dependent [TLR] *activation* of the pathway alone is not required for signaling and that TLR pathway components may negatively regulate expression of sVSG induced signaling . Positive_regulation TLR7 TRAF6 22522491 2602266 This led to enhanced Fps activity and recruitment of the phosphatase SHP-2 , which interfered with [TLR] signaling *mediated* by the signaling molecule . Positive_regulation TLR7 TRIM38 22323536 2565472 was *induced* by [TLR] stimulation in an NF-?B dependent manner in macrophages . Positive_regulation TLR7 TSLP 24335833 2880676 Myeloid dendritic cells (mDC) and plasmacytoid dendritic cells ( pDC ) were stimulated by [TLR] ligands ( mDC with TLR1/2 LTA , TLR2 PGN , TLR3 poly I: C , TLR4 LPS , TLR5 Flagellin ) ( pDC with TLR9 CpG2006 , CpG 2216 , TLR7 loxoribine ) in the *presence* or absence of . Positive_regulation TLR7 UMOD 15650774 1369457 *triggers* typical [TLR] signaling , culminating in activation of NF-kappaB . Positive_regulation TLR7 UNC93B1 21097503 2383180 is *essential* for [TLR11] activation and IL-12 dependent host resistance to Toxoplasma gondii . Positive_regulation TLR7 VEGFA 18375743 1912944 We conclude that multiple [TLR] ligands *induce* airway epithelial cell production of IL-8 and via a Duox1 -- > ROS -- > TACE -- > TGF-alpha -- > EGFR phosphorylation pathway . Positive_regulation TLR7 VEGFA 21998580 2493702 In the current study , we identify HSV-1 infected cells as the dominant source of VEGF-A during acute infection , and transcription did not *require* [TLR] signaling or MAP kinase activation . Positive_regulation TLR7 XBP1 20351694 2244922 [TLR] *activation* of the transcription factor regulates innate immune responses in macrophages . Positive_regulation TLR7 ZC3H12A 23422584 2764966 Here we report that although was *induced* by various [toll-like receptor (TLR)] ligands in macrophages , MCPIP1-deficient mice are extremely susceptible to TLR4 ligand ( LPS ) -induced septic shock and death , but not to the TLR2 , 3 , 5 and 9 ligands induced septic shock . Positive_regulation TLR7 ZC3H12D 22036805 2527483 We here report that negatively *regulates* [TLR] signaling and macrophage activation . Positive_regulation TLR8 IL1B 17459804 1731506 Secretion of the proinflammatory cytokine *requires* caspase-1 and [Toll-like receptor (TLR)] signaling . Positive_regulation TLR8 IL1B 17467812 1737406 [TLR] stimulation of RA-FLS also *induced* the production of and TNF-alpha to a lesser extent ; Positive_regulation TLR8 IL1B 18832719 1971212 A phosphatidylserine species inhibits a range of [TLR-] but not *induced* inflammatory responses by disruption of membrane microdomains . Positive_regulation TLR8 IL1B 20200276 2229582 Caspase-1 independent production is critical for host resistance to mycobacterium tuberculosis and does not *require* [TLR] signaling in vivo . Positive_regulation TLR8 SELL 23573259 2768081 [Toll-Like Receptor] *induced* CD11b and response in patients with coronary artery disease . Positive_regulation TLR8 TNF 12133979 967097 Moreover , various [TLR] ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* NF-kappa B activation and up-regulated production in osteoclast precursor cells . Positive_regulation TLR8 TNF 16847431 1600287 Etanercept , a humanized soluble recombinant p75 TNF-receptor/IgG ( 1 ) Fc fusionprotein , neutralized synergistic CXCL9 production *induced* by plus IFN-gamma , but not synergy between IFN-gamma and the [TLR] ligands PGN or LPS . Positive_regulation TLR8 TNF 17467812 1737405 [TLR] stimulation of RA-FLS also *induced* the production of IL-1beta and to a lesser extent ; Positive_regulation TLR8 TNF 19454685 2084534 [TLR] activation *induces* production from adult neural stem/progenitor cells . Positive_regulation TLR8 TNF 20148136 2208411 Although secretion by adipose cells is probably *induced* , most notably by [TLR] ligands , the activation and secretion pathways of this cytokine are not yet entirely understood . Positive_regulation TLR8 TNFSF10 19369481 2089025 Porcine NK cells express both TLR7 and [TLR8] mRNAs , and treatment with these TLR agonists *induced* higher mRNA expression levels of and IL-15Ralpha , which may contribute to the activity of NK cells . Positive_regulation TLR9 IL1B 17459804 1731507 Secretion of the proinflammatory cytokine *requires* caspase-1 and [Toll-like receptor (TLR)] signaling . Positive_regulation TLR9 IL1B 17467812 1737408 [TLR] stimulation of RA-FLS also *induced* the production of and TNF-alpha to a lesser extent ; Positive_regulation TLR9 IL1B 18832719 1971213 A phosphatidylserine species inhibits a range of [TLR-] but not *induced* inflammatory responses by disruption of membrane microdomains . Positive_regulation TLR9 IL1B 19222370 2054429 The transcription of was *induced* through mannose receptor ( MR ) , Toll-like receptor (TLR) 2 , and dectin-1 but not through TLR4 and [TLR9] . Positive_regulation TLR9 IL1B 19401392 2114617 We found that [TLR-9] stimulation with CpG ODN *induces* , TNF-alpha , IL-10 , and IL-6 production . Positive_regulation TLR9 IL1B 20200276 2229583 Caspase-1 independent production is critical for host resistance to mycobacterium tuberculosis and does not *require* [TLR] signaling in vivo . Positive_regulation TLR9 IL1B 20347818 2281738 In a mouse model of NASH , [TLR9] signaling *induces* production of by Kupffer cells , leading to steatosis , inflammation , and fibrosis . Positive_regulation TLR9 SELL 23573259 2768083 [Toll-Like Receptor] *induced* CD11b and response in patients with coronary artery disease . Positive_regulation TLR9 TLR7 16436336 1516461 During the allergic reaction , engagement on DC directs the polarization of the T cell response and , while TLR2 and TLR4 may favour both Th1 and Th2 responses , [TLR9] *induces* the development of regulatory T cells . Positive_regulation TLR9 TLR7 20089701 2206071 We previously found that was *required* for anti-Sm and [Tlr9] for anti-chromatin autoantibodies . Positive_regulation TLR9 TLR7 21490291 2434580 TLR7 and [TLR9] expression levels were *induced* 4.2- and 9-fold , respectively , whereas other and nucleotide binding oligomerization domain receptors were not modified . Positive_regulation TLR9 TLR7 22434514 2624435 Data from mouse models suggest a pathogenic role for and a protective *role* for [TLR9] in the pathogenesis of SLE . Positive_regulation TLR9 TLR7 22734582 2670128 TLR-9 and *induced* IFN-a and TNF-a production by pDCs was severely impaired in 36 % ( [TLR-9] ) and 33 % ( TLR-7 ) of SLE subjects . Positive_regulation TLR9 TLR7 23742868 2828089 [TLR9] was *induced* in the skin and gill , whereas was induced in the head kidney and spleen after infection . Positive_regulation TLR9 TNF 12133979 967100 Moreover , various [TLR] ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* NF-kappa B activation and up-regulated production in osteoclast precursor cells . Positive_regulation TLR9 TNF 16847431 1600289 Etanercept , a humanized soluble recombinant p75 TNF-receptor/IgG ( 1 ) Fc fusionprotein , neutralized synergistic CXCL9 production *induced* by plus IFN-gamma , but not synergy between IFN-gamma and the [TLR] ligands PGN or LPS . Positive_regulation TLR9 TNF 17467812 1737407 [TLR] stimulation of RA-FLS also *induced* the production of IL-1beta and to a lesser extent ; Positive_regulation TLR9 TNF 19454685 2084535 [TLR] activation *induces* production from adult neural stem/progenitor cells . Positive_regulation TLR9 TNF 19685493 2186207 TLR-7 and [TLR-9] stimulation *induces* production of IL-6 and . Positive_regulation TLR9 TNF 20148136 2208412 Although secretion by adipose cells is probably *induced* , most notably by [TLR] ligands , the activation and secretion pathways of this cytokine are not yet entirely understood . Positive_regulation TLR9 TNF 20483722 2269993 Recent studies have suggested that TLR9 signaling in early endosomes leads to IFN-alpha production by plasmacytoid dendritic cells ( pDCs ) , whereas [TLR9] signaling in late endosomes *induces* pDC maturation , IL-6 , and secretion . Positive_regulation TLR9 TNFSF10 19577819 2117567 In this study , we report that TLR7 and [TLR9] ligands can *induce* the secretion of biologically active ( TRAIL ) by PDC . Positive_regulation TM4SF19 ITGAM 10529602 561981 Cross linking of some surface [TM4SF] molecules *induced* significant eosinophil homotypic aggregation , upregulation of expression , or CD62L shedding , consistent with activation of eosinophils . Positive_regulation TMED10 EPHB2 15067199 1231866 Taken together , the results demonstrate the functional role for ERK and p23 in the neurite elongation activity of FK506 and reveal a novel signal transduction pathway involving [p23] *activation* of . Positive_regulation TMED10 IL1B 12948934 1185433 In response to hrHRF , these cells induced IL-8 mRNA expression within 4 h. H2O2 , but not or tumor necrosis factor-alpha , *stimulated* secretion of HRF [p23] by BEAS-2B cells , suggesting that oxidative stress may trigger the release of HRF p23 from bronchial epithelial cells . Positive_regulation TMED10 TNF 12948934 1185432 In response to hrHRF , these cells induced IL-8 mRNA expression within 4 h. H2O2 , but not IL-1 beta or , *stimulated* secretion of HRF [p23] by BEAS-2B cells , suggesting that oxidative stress may trigger the release of HRF p23 from bronchial epithelial cells . Positive_regulation TMED2 IL1B 8529133 336693 IL-1 alpha and *increased* [p24] antigen production in a concentration dependent manner . Positive_regulation TMED7 CCND1 10377442 623838 Silibinin induced G1 arrest was associated with a marked decrease in the kinase activity of cyclin dependent kinases (CDKs) and associated cyclins because of a highly significant decrease in , CDK4 , and CDK6 levels and an *induction* of Cip1/p21 and [Kip1/p27] followed by their increased binding with CDK2 . Positive_regulation TMED7 CCND1 12761887 1091767 Studies also indicate that [p27] is functionally active and that its loss of action on Cdks in proliferating cells is *due* to its strong association with . Positive_regulation TMED7 CCND1 14566962 1155092 This was associated with increased protein content of and Cdk4 and decreased *activation* of p21 ( cip1 ) and [p27] ( kip1 ) . Positive_regulation TMED7 CCND1 16916940 1646407 By contrast , TSH repressed or did not *induce* and p21 , and it rather up-regulated [p27] . Positive_regulation TMED7 CCND1 17047061 1635859 induction of cellular migration *requires* [p27] ( KIP1 ) . Positive_regulation TMED7 CCND1 17047061 1635861 regulated p27 ( KIP1 ) abundance at the posttranslational level , inhibiting the Skp2 promoter , Skp2 abundance , and *induced* [p27] ( KIP1 ) phosphorylation at Ser ( 10 ) . Positive_regulation TMED7 CCND1 17089025 1644256 [p27] ( KIP1 ) phosphorylation and *induction* were inhibited by PD98059 . Positive_regulation TMED7 CCND1 17438373 1729263 Coexpression of , but not cyclin E , is *sufficient* to restore [p27] levels in PTEN expressing cells . Positive_regulation TMED7 CCND1 18464245 1921422 This inhibitory phenomenon was associated with the reduced expressions of cyclin B1 , and cdc25B but *increased* expression of [p27] ( Kip1 ) and p21 ( Cip1 ) . Positive_regulation TMED7 CCND1 18710949 1968224 However , Src treatment led to tyrosine phosphorylation of [p27] and catalytic *activation* of assembled complexes . Positive_regulation TMED7 CCND1 20837141 2363748 The induction of expression *leads* to a targeted [p27] ( Kip1 ) accumulation in both cytoplasmic and nuclear compartments . Positive_regulation TMED7 CCND1 22771367 2676459 We found that TS extracts ( 10-75 µg/mL ) arrested HL-60 cells at the G1-S transition phase through the reductions of , CDK4 , Cyclin E , CDK2 , and Cyclin A , and *induction* of CDK inhibitor [p27KIP] levels . Positive_regulation TMED7 CCND1 24023847 2842019 Knockdown of Livin induced the apoptosis by up-regulating of caspase-3 , -7 and PARP activities and the cell cycle arrest by decreasing , cyclin D3 , cyclin dependent kinase 4 and 6 , and by *inducing* [p27] expression . Positive_regulation TMED7 CCND1 24178620 2896972 Immunoprecipitation analyses and siRNA assays suggested a direct *role* of in the regulation of [p27] ( KIP1 ) levels . Positive_regulation TMED7 CCND1 24639504 2930444 SMAD7 promotes beta-cell proliferation by increasing and CyclinD2 , and by *inducing* nuclear exclusion of [p27] . Positive_regulation TMED7 CTGF 16790529 1590938 Further investigation of other Akt/PKB sites on p27 ( Kip-1 ) , revealed that phosphorylation on threonine 157 was necessary for *mediated* [p27] ( Kip-1 ) cytoplasmic localization ; Positive_regulation TMED7 CTGF 16790529 1590940 also *stimulated* an increased association between Rho A and [p27] ( Kip-1 ) . Positive_regulation TMED7 EPHB2 10781803 687945 This implies that a link exists between activation and p21 ( WAF ) and [p27] ( kip1 ) *induction* in the process of terminal differentiation . Positive_regulation TMED7 EPHB2 17893107 1823883 In stimulated MC , inhibition of *reduced* cyclin dependent kinase 2 (CDK2) phosphorylation , CDK2 activity and cyclin E/A expression , whereas downregulation of CDK inhibitor [p27] ( Kip1 ) expression was inhibited . Positive_regulation TMED7 FOXA1 16331276 1526288 In transient transfection reporter assays , could *activate* the [p27] ( Kip1 ) promoter . Positive_regulation TMED7 FOXA1 17163418 1687963 In the estrogen receptor (ER) positive MCF-7 cells , *increased* [p27] promoter activity and inhibited the ER pathway activity . Positive_regulation TMED7 FOXO1 17015685 1629787 Consistent with the important *role* of in [p27] kip1 transcription , stimulated Vav1 ( -/- ) T cells failed to down-regulate the expression of p27 kip1 , explaining their G0-G1 arrest . Positive_regulation TMED7 FOXO1 17408630 1728357 directly *induces* the expression of [p27] ( kip1 ) and manganese superoxide dismutase ( MnSOD ) . Positive_regulation TMED7 FOXO1 18787071 1986174 The objectives of the present study were to 1 ) locate and identify FOXO regulatory elements in the rat p27 ( Kip1 ) promoter using deletion analysis of a promoter/reporter construct and 2 ) determine if age related differences exist in *induced* [p27] ( Kip1 ) expression . Positive_regulation TMED7 FOXO1 18787071 1986183 Site-specific mutation of a daf-16 family protein binding element ( DBE ) within this 253-bp portion of the 5'-UTR also demonstrated a decrease in *induced* [p27] ( Kip1 ) promoter expression . Positive_regulation TMED7 FOXO1 19281796 2055705 PARP-1 represses *mediated* expression of cell cycle inhibitor [p27] ( Kip1 ) gene . Positive_regulation TMED7 ID1 12016143 942188 We found that expression *induced* phosphorylation of RB and down-regulation of p16(INK4a) but not p21 ( Waf1 ) or [p27] ( Kip1 ) . Positive_regulation TMED7 ID1 19079342 2030879 *activates* Akt mediated Wnt signaling and [p27] ( Kip1 ) phosphorylation through PTEN inhibition . Positive_regulation TMED7 IFI27 16397251 1506274 Transduction with CRAD + replication-defective adenovirus-p27 *increased* the expression of [p27] by 24-fold versus transduction with alone . Positive_regulation TMED7 IFI27 18701472 1950373 Cytoplasmic localization of [p27] in Tsc2-null cells was reversible pharmacologically using inhibitors of the LKB1/AMPK pathway , and localization of to the cytoplasm could be *induced* directly by activating AMPK physiologically ( glucose deprivation ) or genetically ( constitutively active AMPK ) in Tsc2-proficient cells . Positive_regulation TMED7 IFI27 18818203 1993567 Stabilization of [p27] in G ( 0 ) in BCL2 or BCL-x ( L ) cells was *due* to phosphorylation of at Ser ( 10 ) by the kinase Mirk . Positive_regulation TMED7 IFI27 20146253 2242346 AMPK mediated phosphorylation of murine at T197 promotes binding of 14-3-3 proteins and *increases* [p27] stability . Positive_regulation TMED7 IFI27 21818355 2462924 Our results show that expression of [p27] ( kip ) was lost in the IRF4 ( +/- ) Myc leukemic cells and reconstitution of IRF4 expression in those cells *induced* ( kip ) and inhibited their expansion . Positive_regulation TMED7 ITGB2 16894473 1597173 Our results showed that ( 1A ) *increased* the [p27] protein amount , both in cytoplasm and nucleus , but did not affect the p27 mRNA amount . Positive_regulation TMED7 JAG1 23965337 2845534 We propose a receptor-specific function for Notch2 in regulating *induced* [p27] ( kip1 ) expression and growth arrest in VSMCs . Positive_regulation TMED7 TNF 21075101 2371469 Meanwhile , not only *induced* the [p27] ( kip ) expression and cell cycle arrest in the G ( 0 ) -G ( 1 ) phase , but also enhanced caspase-3 activity and induced apoptosis in SMCs of asymptomatic plaques . Positive_regulation TMED7 TP63 19377509 2081918 Ets-1 [p27] blocks Ets-1 p51 mediated transactivation of target genes and *induces* the translocation of Ets-1 from the nucleus to the cytoplasm . Positive_regulation TMED9 CAPN8 23954626 2836025 We found that exposure of PC12 cells to ASN increases Cdk5 activity via *dependent* [p25] formation and by enhancement of Cdk5 phosphorylation at Tyr15 . Positive_regulation TMEM100 CLEC1B 22293702 2546139 Furthermore , podoplanin , another [transmembrane protein] in lymphatic vessels is *required* for their separation from veins by activating , the specific ligand in platelets , leading to thrombus formation between veins and lymphatic vessels . Positive_regulation TMEM100 CSF2 19641137 2124822 *induced* the expression of dendritic cell-specific [transmembrane protein] ( DC-STAMP ) , which was mediated by inducing NFATc1 via induction of c-Fos . Positive_regulation TMEM100 EGFR 19074872 2002911 Our study shows that in human carcinoma ( A431 ) and glioma ( U373 ) cells , the oncogenic forms of ( EGFR ; including EGFRvIII ) *trigger* the up-regulation of tissue factor ( TF ) , the [transmembrane protein] responsible for initiating blood coagulation and signaling through interaction with coagulation factor VIIa . Positive_regulation TMEM100 EXOC8 17698923 1782403 activity is *essential* for the apical localization of the Crumbs [transmembrane protein] , a key determinant of epithelial apical identity . Positive_regulation TMEM100 HGF 10713700 676084 exerts its biological effects via binding and *activating* a [transmembrane protein] tyrosine kinase receptor known as c-Met . Positive_regulation TMEM100 IL32 22068911 2547809 In addition , we demonstrated that *induced* the expression of dendritic cell-specific [transmembrane protein] ( DC-STAMP ) and nuclear factor of activated T cells cytoplasmic 1 ( NFATc1 ) , and NFATc1 inactivation by cyclosporine treatment attenuated the effect of IL-32? . Positive_regulation TMEM100 IL4 17855502 1823219 Furthermore , we found that *induced* expression of E-cadherin and dendritic cell-specific [transmembrane protein] in a STAT6 dependent manner . Positive_regulation TMEM100 INS 24141772 2955671 Haeme-responsive gene (HRG)-1 encodes a 16-kDa [transmembrane protein] that is *induced* by and associates with the vacuolar- ( H ( + ) ) ATPase ( V-ATPase ) . Positive_regulation TMEM100 KLC1 22404616 2593370 An artificial [transmembrane protein] containing either WD motif induced kinesin-1 's vesicular association and anterograde transport in a KLC dependent manner , even in the normally inhibiting *presence* of excess , thus allowing us to analyze the KLC1 TPR-WD functional interaction in detail in vivo . Positive_regulation TMEM100 NEUROD1 22951639 2672904 Here , we show that Gde2 , a [six-transmembrane protein] that *induces* spinal , is expressed in the developing cortex throughout cortical neurogenesis . Positive_regulation TMEM100 NEUROD2 22951639 2672905 Here , we show that Gde2 , a [six-transmembrane protein] that *induces* spinal , is expressed in the developing cortex throughout cortical neurogenesis . Positive_regulation TMEM100 NEUROD4 22951639 2672902 Here , we show that Gde2 , a [six-transmembrane protein] that *induces* spinal , is expressed in the developing cortex throughout cortical neurogenesis . Positive_regulation TMEM100 NEUROD6 22951639 2672903 Here , we show that Gde2 , a [six-transmembrane protein] that *induces* spinal , is expressed in the developing cortex throughout cortical neurogenesis . Positive_regulation TMEM100 NFATC1 22068911 2547810 In addition , we demonstrated that IL-32? *induced* the expression of dendritic cell-specific [transmembrane protein] ( DC-STAMP ) and nuclear factor of activated T cells cytoplasmic 1 ( ) , and NFATc1 inactivation by cyclosporine treatment attenuated the effect of IL-32? . Positive_regulation TMEM100 PIK3CA 21068542 2365814 Atg9 is a [transmembrane protein] essential for autophagy which cycles between the Golgi network , late endosomes and LC3 positive autophagosomes in mammalian cells during starvation through a mechanism that is dependent on ULK1 and *requires* the activity of the class III ( PI3KC3 ) . Positive_regulation TMEM100 PIK3R1 21068542 2365815 Atg9 is a [transmembrane protein] essential for autophagy which cycles between the Golgi network , late endosomes and LC3 positive autophagosomes in mammalian cells during starvation through a mechanism that is dependent on ULK1 and *requires* the activity of the class III ( PI3KC3 ) . Positive_regulation TMEM100 RUNX1 11396961 823473 A hematopoietic-specific [transmembrane protein] , Art-1 , is possibly *regulated* by . Positive_regulation TMEM100 TNF 21635942 2450794 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM101 TNF 21635942 2450860 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM102 TNF 21635942 2450823 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM104 TNF 21635942 2450803 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM105 TNF 21635942 2450825 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM107 TNF 21635942 2450840 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM108 TNF 21635942 2450853 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM109 TNF 21635942 2450862 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM11 TNF 21635942 2450746 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM110 TNF 21635942 2450874 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM114 TNF 21635942 2450888 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM115 TNF 21635942 2450868 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM116 TNF 21635942 2450774 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM117 TNF 21635942 2450782 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM119 TNF 21635942 2450834 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM121 TNF 21635942 2450756 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM123 TNF 21635942 2450870 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM125 TNF 21635942 2450848 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM127 TNF 21635942 2450804 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM128 TNF 21635942 2450845 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM129 TNF 21635942 2450777 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM130 TNF 21635942 2450785 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM131 TNF 21635942 2450872 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM133 TNF 21635942 2450768 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM134 TNF 21635942 2450807 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM135 TNF 21635942 2450808 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM136 TNF 21635942 2450849 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM138 TNF 21635942 2450827 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM139 TNF 21635942 2450765 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM140 TNF 21635942 2450762 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM141 TNF 21635942 2450846 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM143 TNF 21635942 2450792 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM144 TNF 21635942 2450797 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM145 TNF 21635942 2450826 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM147 TNF 21635942 2450873 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM154 TNF 21635942 2450818 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM155 TNF 21635942 2450816 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM156 CLEC1B 22293702 2546157 Furthermore , podoplanin , another [transmembrane protein] in lymphatic vessels is *required* for their separation from veins by activating , the specific ligand in platelets , leading to thrombus formation between veins and lymphatic vessels . Positive_regulation TMEM156 CSF2 19641137 2124840 *induced* the expression of dendritic cell-specific [transmembrane protein] ( DC-STAMP ) , which was mediated by inducing NFATc1 via induction of c-Fos . Positive_regulation TMEM156 EGFR 19074872 2002929 Our study shows that in human carcinoma ( A431 ) and glioma ( U373 ) cells , the oncogenic forms of ( EGFR ; including EGFRvIII ) *trigger* the up-regulation of tissue factor ( TF ) , the [transmembrane protein] responsible for initiating blood coagulation and signaling through interaction with coagulation factor VIIa . Positive_regulation TMEM156 EXOC8 17698923 1782421 activity is *essential* for the apical localization of the Crumbs [transmembrane protein] , a key determinant of epithelial apical identity . Positive_regulation TMEM156 HGF 10713700 676102 exerts its biological effects via binding and *activating* a [transmembrane protein] tyrosine kinase receptor known as c-Met . Positive_regulation TMEM156 IL32 22068911 2547845 In addition , we demonstrated that *induced* the expression of dendritic cell-specific [transmembrane protein] ( DC-STAMP ) and nuclear factor of activated T cells cytoplasmic 1 ( NFATc1 ) , and NFATc1 inactivation by cyclosporine treatment attenuated the effect of IL-32? . Positive_regulation TMEM156 IL4 17855502 1823237 Furthermore , we found that *induced* expression of E-cadherin and dendritic cell-specific [transmembrane protein] in a STAT6 dependent manner . Positive_regulation TMEM156 INS 24141772 2955689 Haeme-responsive gene (HRG)-1 encodes a 16-kDa [transmembrane protein] that is *induced* by and associates with the vacuolar- ( H ( + ) ) ATPase ( V-ATPase ) . Positive_regulation TMEM156 KLC1 22404616 2593388 An artificial [transmembrane protein] containing either WD motif induced kinesin-1 's vesicular association and anterograde transport in a KLC dependent manner , even in the normally inhibiting *presence* of excess , thus allowing us to analyze the KLC1 TPR-WD functional interaction in detail in vivo . Positive_regulation TMEM156 NEUROD1 22951639 2672976 Here , we show that Gde2 , a [six-transmembrane protein] that *induces* spinal , is expressed in the developing cortex throughout cortical neurogenesis . Positive_regulation TMEM156 NEUROD2 22951639 2672977 Here , we show that Gde2 , a [six-transmembrane protein] that *induces* spinal , is expressed in the developing cortex throughout cortical neurogenesis . Positive_regulation TMEM156 NEUROD4 22951639 2672974 Here , we show that Gde2 , a [six-transmembrane protein] that *induces* spinal , is expressed in the developing cortex throughout cortical neurogenesis . Positive_regulation TMEM156 NEUROD6 22951639 2672975 Here , we show that Gde2 , a [six-transmembrane protein] that *induces* spinal , is expressed in the developing cortex throughout cortical neurogenesis . Positive_regulation TMEM156 NFATC1 22068911 2547846 In addition , we demonstrated that IL-32? *induced* the expression of dendritic cell-specific [transmembrane protein] ( DC-STAMP ) and nuclear factor of activated T cells cytoplasmic 1 ( ) , and NFATc1 inactivation by cyclosporine treatment attenuated the effect of IL-32? . Positive_regulation TMEM156 PIK3CA 21068542 2365850 Atg9 is a [transmembrane protein] essential for autophagy which cycles between the Golgi network , late endosomes and LC3 positive autophagosomes in mammalian cells during starvation through a mechanism that is dependent on ULK1 and *requires* the activity of the class III ( PI3KC3 ) . Positive_regulation TMEM156 PIK3R1 21068542 2365851 Atg9 is a [transmembrane protein] essential for autophagy which cycles between the Golgi network , late endosomes and LC3 positive autophagosomes in mammalian cells during starvation through a mechanism that is dependent on ULK1 and *requires* the activity of the class III ( PI3KC3 ) . Positive_regulation TMEM156 RUNX1 11396961 823491 A hematopoietic-specific [transmembrane protein] , Art-1 , is possibly *regulated* by . Positive_regulation TMEM156 TNF 21635942 2450812 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM158 TNF 21635942 2450871 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM159 TNF 21635942 2450869 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM160 TNF 21635942 2450805 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM163 TNF 21635942 2450784 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM164 TNF 21635942 2450811 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM165 TNF 21635942 2450876 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM168 TNF 21635942 2450799 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM169 TNF 21635942 2450776 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM17 TNF 21635942 2450822 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM171 TNF 21635942 2450828 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM173 TNF 21635942 2450837 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM174 TNF 21635942 2450843 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM175 TNF 21635942 2450861 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM177 TNF 21635942 2450841 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM179 TNF 21635942 2450753 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM18 TNF 21635942 2450781 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM180 TNF 21635942 2450810 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM181 TNF 21635942 2450757 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM182 TNF 21635942 2450814 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM186 TNF 21635942 2450771 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM187 TNF 21635942 2450741 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM189 TNF 21635942 2450745 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM19 TNF 21635942 2450793 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM190 TNF 21635942 2450867 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM192 TNF 21635942 2450824 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM196 TNF 21635942 2450766 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM198 TNF 21635942 2450889 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM199 TNF 21635942 2450749 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM2 TNF 21635942 2450737 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM201 TNF 21635942 2450891 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM202 TNF 21635942 2450893 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM203 TNF 21635942 2450847 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM204 TNF 21635942 2450742 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM205 TNF 21635942 2450866 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM206 TNF 21635942 2450791 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM207 TNF 21635942 2450890 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM208 TNF 21635942 2450772 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM209 TNF 21635942 2450763 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM210 TNF 21635942 2450896 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM211 CLEC1B 22293702 2546237 Furthermore , podoplanin , another [transmembrane protein] in lymphatic vessels is *required* for their separation from veins by activating , the specific ligand in platelets , leading to thrombus formation between veins and lymphatic vessels . Positive_regulation TMEM211 CSF2 19641137 2124920 *induced* the expression of dendritic cell-specific [transmembrane protein] ( DC-STAMP ) , which was mediated by inducing NFATc1 via induction of c-Fos . Positive_regulation TMEM211 EGFR 19074872 2003009 Our study shows that in human carcinoma ( A431 ) and glioma ( U373 ) cells , the oncogenic forms of ( EGFR ; including EGFRvIII ) *trigger* the up-regulation of tissue factor ( TF ) , the [transmembrane protein] responsible for initiating blood coagulation and signaling through interaction with coagulation factor VIIa . Positive_regulation TMEM211 EXOC8 17698923 1782501 activity is *essential* for the apical localization of the Crumbs [transmembrane protein] , a key determinant of epithelial apical identity . Positive_regulation TMEM211 HGF 10713700 676182 exerts its biological effects via binding and *activating* a [transmembrane protein] tyrosine kinase receptor known as c-Met . Positive_regulation TMEM211 IL32 22068911 2548005 In addition , we demonstrated that *induced* the expression of dendritic cell-specific [transmembrane protein] ( DC-STAMP ) and nuclear factor of activated T cells cytoplasmic 1 ( NFATc1 ) , and NFATc1 inactivation by cyclosporine treatment attenuated the effect of IL-32? . Positive_regulation TMEM211 IL4 17855502 1823317 Furthermore , we found that *induced* expression of E-cadherin and dendritic cell-specific [transmembrane protein] in a STAT6 dependent manner . Positive_regulation TMEM211 INS 24141772 2955769 Haeme-responsive gene (HRG)-1 encodes a 16-kDa [transmembrane protein] that is *induced* by and associates with the vacuolar- ( H ( + ) ) ATPase ( V-ATPase ) . Positive_regulation TMEM211 KLC1 22404616 2593468 An artificial [transmembrane protein] containing either WD motif induced kinesin-1 's vesicular association and anterograde transport in a KLC dependent manner , even in the normally inhibiting *presence* of excess , thus allowing us to analyze the KLC1 TPR-WD functional interaction in detail in vivo . Positive_regulation TMEM211 NEUROD1 22951639 2673296 Here , we show that Gde2 , a [six-transmembrane protein] that *induces* spinal , is expressed in the developing cortex throughout cortical neurogenesis . Positive_regulation TMEM211 NEUROD2 22951639 2673297 Here , we show that Gde2 , a [six-transmembrane protein] that *induces* spinal , is expressed in the developing cortex throughout cortical neurogenesis . Positive_regulation TMEM211 NEUROD4 22951639 2673294 Here , we show that Gde2 , a [six-transmembrane protein] that *induces* spinal , is expressed in the developing cortex throughout cortical neurogenesis . Positive_regulation TMEM211 NEUROD6 22951639 2673295 Here , we show that Gde2 , a [six-transmembrane protein] that *induces* spinal , is expressed in the developing cortex throughout cortical neurogenesis . Positive_regulation TMEM211 NFATC1 22068911 2548006 In addition , we demonstrated that IL-32? *induced* the expression of dendritic cell-specific [transmembrane protein] ( DC-STAMP ) and nuclear factor of activated T cells cytoplasmic 1 ( ) , and NFATc1 inactivation by cyclosporine treatment attenuated the effect of IL-32? . Positive_regulation TMEM211 PIK3CA 21068542 2366010 Atg9 is a [transmembrane protein] essential for autophagy which cycles between the Golgi network , late endosomes and LC3 positive autophagosomes in mammalian cells during starvation through a mechanism that is dependent on ULK1 and *requires* the activity of the class III ( PI3KC3 ) . Positive_regulation TMEM211 PIK3R1 21068542 2366011 Atg9 is a [transmembrane protein] essential for autophagy which cycles between the Golgi network , late endosomes and LC3 positive autophagosomes in mammalian cells during starvation through a mechanism that is dependent on ULK1 and *requires* the activity of the class III ( PI3KC3 ) . Positive_regulation TMEM211 RUNX1 11396961 823571 A hematopoietic-specific [transmembrane protein] , Art-1 , is possibly *regulated* by . Positive_regulation TMEM211 TNF 21635942 2450892 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM212 TNF 21635942 2450897 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM213 CLEC1B 22293702 2546174 Furthermore , podoplanin , another [transmembrane protein] in lymphatic vessels is *required* for their separation from veins by activating , the specific ligand in platelets , leading to thrombus formation between veins and lymphatic vessels . Positive_regulation TMEM213 CSF2 19641137 2124857 *induced* the expression of dendritic cell-specific [transmembrane protein] ( DC-STAMP ) , which was mediated by inducing NFATc1 via induction of c-Fos . Positive_regulation TMEM213 EGFR 19074872 2002946 Our study shows that in human carcinoma ( A431 ) and glioma ( U373 ) cells , the oncogenic forms of ( EGFR ; including EGFRvIII ) *trigger* the up-regulation of tissue factor ( TF ) , the [transmembrane protein] responsible for initiating blood coagulation and signaling through interaction with coagulation factor VIIa . Positive_regulation TMEM213 EXOC8 17698923 1782438 activity is *essential* for the apical localization of the Crumbs [transmembrane protein] , a key determinant of epithelial apical identity . Positive_regulation TMEM213 HGF 10713700 676119 exerts its biological effects via binding and *activating* a [transmembrane protein] tyrosine kinase receptor known as c-Met . Positive_regulation TMEM213 IL32 22068911 2547879 In addition , we demonstrated that *induced* the expression of dendritic cell-specific [transmembrane protein] ( DC-STAMP ) and nuclear factor of activated T cells cytoplasmic 1 ( NFATc1 ) , and NFATc1 inactivation by cyclosporine treatment attenuated the effect of IL-32? . Positive_regulation TMEM213 IL4 17855502 1823254 Furthermore , we found that *induced* expression of E-cadherin and dendritic cell-specific [transmembrane protein] in a STAT6 dependent manner . Positive_regulation TMEM213 INS 24141772 2955706 Haeme-responsive gene (HRG)-1 encodes a 16-kDa [transmembrane protein] that is *induced* by and associates with the vacuolar- ( H ( + ) ) ATPase ( V-ATPase ) . Positive_regulation TMEM213 KLC1 22404616 2593405 An artificial [transmembrane protein] containing either WD motif induced kinesin-1 's vesicular association and anterograde transport in a KLC dependent manner , even in the normally inhibiting *presence* of excess , thus allowing us to analyze the KLC1 TPR-WD functional interaction in detail in vivo . Positive_regulation TMEM213 NEUROD1 22951639 2673044 Here , we show that Gde2 , a [six-transmembrane protein] that *induces* spinal , is expressed in the developing cortex throughout cortical neurogenesis . Positive_regulation TMEM213 NEUROD2 22951639 2673045 Here , we show that Gde2 , a [six-transmembrane protein] that *induces* spinal , is expressed in the developing cortex throughout cortical neurogenesis . Positive_regulation TMEM213 NEUROD4 22951639 2673042 Here , we show that Gde2 , a [six-transmembrane protein] that *induces* spinal , is expressed in the developing cortex throughout cortical neurogenesis . Positive_regulation TMEM213 NEUROD6 22951639 2673043 Here , we show that Gde2 , a [six-transmembrane protein] that *induces* spinal , is expressed in the developing cortex throughout cortical neurogenesis . Positive_regulation TMEM213 NFATC1 22068911 2547880 In addition , we demonstrated that IL-32? *induced* the expression of dendritic cell-specific [transmembrane protein] ( DC-STAMP ) and nuclear factor of activated T cells cytoplasmic 1 ( ) , and NFATc1 inactivation by cyclosporine treatment attenuated the effect of IL-32? . Positive_regulation TMEM213 PIK3CA 21068542 2365884 Atg9 is a [transmembrane protein] essential for autophagy which cycles between the Golgi network , late endosomes and LC3 positive autophagosomes in mammalian cells during starvation through a mechanism that is dependent on ULK1 and *requires* the activity of the class III ( PI3KC3 ) . Positive_regulation TMEM213 PIK3R1 21068542 2365885 Atg9 is a [transmembrane protein] essential for autophagy which cycles between the Golgi network , late endosomes and LC3 positive autophagosomes in mammalian cells during starvation through a mechanism that is dependent on ULK1 and *requires* the activity of the class III ( PI3KC3 ) . Positive_regulation TMEM213 RUNX1 11396961 823508 A hematopoietic-specific [transmembrane protein] , Art-1 , is possibly *regulated* by . Positive_regulation TMEM213 TNF 21635942 2450829 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM214 TNF 21635942 2450802 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM215 TNF 21635942 2450895 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM216 TNF 21635942 2450773 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM217 TNF 21635942 2450758 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM218 TNF 21635942 2450831 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM219 TNF 21635942 2450779 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM220 TNF 21635942 2450894 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM221 TNF 21635942 2450764 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM222 TNF 21635942 2450783 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM223 TNF 21635942 2450854 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM225 TNF 21635942 2450885 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM230 TNF 21635942 2450744 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM231 TNF 21635942 2450899 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM232 TNF 21635942 2450900 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM233 TNF 21635942 2450898 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM234 TNF 21635942 2450864 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM235 TNF 21635942 2450833 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM236 TNF 21635942 2450767 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM237 TNF 21635942 2450743 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM238 TNF 21635942 2450901 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM239 TNF 21635942 2450902 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM240 TNF 21635942 2450778 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM241 TNF 21635942 2450878 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM242 TNF 21635942 2450748 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM243 TNF 21635942 2450760 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM244 TNF 21635942 2450759 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM245 TNF 21635942 2450740 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM246 TNF 21635942 2450842 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM247 TNF 21635942 2450903 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM248 TNF 21635942 2450787 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM249 TNF 21635942 2450904 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM25 TNF 21635942 2450801 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM251 TNF 21635942 2450755 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM252 TNF 21635942 2450856 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM253 TNF 21635942 2450887 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM254 TNF 21635942 2450798 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM256 TNF 21635942 2450859 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM257 TNF 21635942 2450795 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM258 TNF 21635942 2450736 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM259 TNF 21635942 2450747 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM26 TNF 21635942 2450857 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM260 TNF 21635942 2450754 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM261 TNF 21635942 2450875 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM27 TNF 21635942 2450865 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM31 TNF 21635942 2450858 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM33 TNF 21635942 2450789 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM35 TNF 21635942 2450800 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM37 FLG 19825551 2009234 While high doses of either microbe associated molecular pattern ( MAMP ) elicit a late response that includes activation of senescence processes , SA-dependent secretory pathway genes and [PR1] expression are substantially *induced* only by . Positive_regulation TMEM37 TNF 21635942 2450750 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM40 TNF 21635942 2450796 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM42 TNF 21635942 2450852 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM43 TNF 21635942 2450855 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM44 TNF 21635942 2450775 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM47 TNF 21635942 2450751 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM5 TNF 21635942 2450739 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM51 TNF 21635942 2450788 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM52 TNF 21635942 2450836 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM53 TNF 21635942 2450809 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM54 TNF 21635942 2450769 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM56 TNF 21635942 2450817 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM57 TNF 21635942 2450790 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM59 TNF 21635942 2450738 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM60 TNF 21635942 2450761 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM61 TNF 21635942 2450830 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM62 TNF 21635942 2450813 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM64 TNF 21635942 2450786 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM65 TNF 21635942 2450780 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM66 TNF 21635942 2450863 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM67 TNF 21635942 2450851 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM68 TNF 21635942 2450819 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM69 TNF 21635942 2450838 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM70 TNF 21635942 2450806 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM71 TNF 21635942 2450820 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM72 TNF 21635942 2450877 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM74 TNF 21635942 2450815 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM75 TNF 21635942 2450879 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM78 TNF 21635942 2450880 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM79 TNF 21635942 2450844 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM80 TNF 21635942 2450832 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM81 TNF 21635942 2450881 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM82 TNF 21635942 2450882 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM88 TNF 21635942 2450883 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM89 TNF 21635942 2450884 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM9 TNF 21635942 2450752 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM91 TNF 21635942 2450886 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM92 TNF 21635942 2450821 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM95 TNF 21635942 2450835 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM97 TNF 21635942 2450839 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM98 TNF 21635942 2450770 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMEM99 TNF 21635942 2450850 Sequence analysis indicated that the protein is a member of the widespread but hitherto uncharacterised TMPIT ( [transmembrane protein] *inducible* by ) family , so it was labelled TdicTMPIT1 . Positive_regulation TMOD1 ATP5O 2970847 97065 The antibodies reverse caldesmon inhibition of actomyosin ATPase and abolish Ca2+-regulation of native aorta [thin filament] *activation* of myosin . Positive_regulation TMOD1 CA2 10049329 592568 Changes in skeletal troponin C ( sTnC ) structure during [thin filament] *activation* by and strongly bound cross-bridge states were monitored by measuring the linear dichroism of the 5 ' isomer of iodoacetamidotetramethylrhodamine ( 5'IATR ) , attached to Cys98 ( sTnC-5'ATR ) , in sTnC-5'ATR reconstituted single skinned fibers from rabbit psoas muscle . Positive_regulation TMOD1 CA2 10096910 601483 *Role* of and cross-bridges in skeletal muscle [thin filament] activation probed with Ca2+ sensitizers . Positive_regulation TMOD1 CALD1 17562849 1778623 The results suggest that activation of PKC inhibits alpha ( 1 ) -adrenoceptor mediated contractions in PUA through down-regulation of the thick-filament pathway and decreased myosin light chain phosphorylation , but that it enhances the contractions in NPUA through its effect on the [thin-filament] regulatory pathway and *activation* of and actin polymerization . Positive_regulation TMOD1 CALD1 2912089 107059 A mechanism for [thin filament] regulation , *mediated* by , is proposed . Positive_regulation TMOD1 EDN1 2280412 147460 However , a small amount of phosphate ( 17 % ) was detected in a light chain peptide phosphorylated by protein kinase C . also *stimulated* phosphorylation of the [thin filament] protein , caldesmon , ( from 0.35 mol PO4/mol caldesmon to 0.52 mol PO4/mol ) . Positive_regulation TMOD1 EGF 12419997 1013362 Activation of PKCalpha by *causes* an increased phosphorylation of [tropomodulin] which results in an increase in tropomodulin association with cytoskeletal components . Positive_regulation TMOD1 EPHB2 17562849 1778624 The results suggest that activation of PKC inhibits alpha ( 1 ) -adrenoceptor mediated contractions in PUA through down-regulation of the thick-filament pathway and decreased myosin light chain phosphorylation , but that it enhances the contractions in NPUA through its effect on the [thin-filament] regulatory pathway and *activation* of and actin polymerization . Positive_regulation TMOD1 HSPB6 10790164 689039 When homogenates of nitroglycerine relaxed tissues were centrifuged at 6000 g , phosphorylated HSP20 preferentially sedimented in the pellet , suggesting that phosphorylation of may *increase* its affinity for the [thin filament] . Positive_regulation TMOD1 MYO10 10428784 633283 These results suggest that charged residues on the surface of the actin inner domain are important in Ca ( 2+ ) - and *induced* [thin filament] activation . Positive_regulation TMOD1 MYO10 10535949 562862 These results indicate that , in the presence of Tm , the strong binding of cooperatively *activates* the [thin filament] . Positive_regulation TMOD1 MYO10 10775487 686625 The aim of this study was to determine the length-dependence of mediated [thin filament] *activation* in skinned bovine ventricular muscle , as assayed by the generation of force with progressive reduction of MgATP concentration in the absence of Ca ( 2+ ) . Positive_regulation TMOD1 MYO10 11390938 822898 However , it is not muscle length but the lateral spacing between actin and myosin filaments that sets the level of Ca ( 2+ ) sensitivity , mainly through modulation of *mediated* activation of the [thin filament] . Positive_regulation TMOD1 MYO10 12545187 1028795 Inner sequences of tropomyosin , particularly actin binding periods 3 to 5 , play crucial role in *induced* activation of the [thin filament] . Positive_regulation TMOD1 MYO10 14507711 1145087 *Activation* of the calcium regulated [thin filament] by strong binding . Positive_regulation TMOD1 MYO10 15140746 1279567 Isoform switching from SM-B to SM-A *results* in decreased contractility and altered expression of [thin filament] regulatory proteins . Positive_regulation TMOD1 MYO10 17420299 1723803 However , other actions of these motors sustain sarcomeric activation by cooperative feedback mechanisms in which the interaction *promotes* [thin-filament] activation . Positive_regulation TMOD1 MYO10 18165684 1875388 We conclude that the highly conserved Asp-137 destabilizes the middle of Tm , resulting in a more flexible region that is important for the cooperative *activation* of the [thin filament] by . Positive_regulation TMOD1 MYO10 18985725 2015247 The data show that the [thin filament] is cooperatively *activated* by across regulatory units when Tm is phosphorylated . Positive_regulation TMOD1 MYO10 19799913 2195760 In conclusion , E99K inhibits the *activation* of the [thin filament] by strong binding whereas R312H demonstrates enhanced calcium activation . Positive_regulation TMOD1 MYO10 22749829 2639372 Ca ( 2+ ) -sensitivity of the actomyosin interactions , as well as cooperativity of induced *activation* of the [thin filament] was affected by individual tropomyosin mutants with various degrees . Positive_regulation TMOD1 MYO10 7787029 309995 The steepness of the tension-pMgATP relationship , between the region of the curve where tension was zero and the peak tension , is hypothesized to be due to *induced* cooperative activation of the [thin filament] . Positive_regulation TMOD1 MYO10 7787029 310007 The steeper slope in cardiac myocytes provides evidence of greater binding *induced* cooperative activation of the [thin filament] in cardiac as compared with skeletal muscle , at least under these experimental conditions of nominal free Ca2+ . Positive_regulation TMOD1 MYO10 7787029 310031 These results suggest that , in the absence of Ca2+ , mediated *activation* of the [thin filament] is greater in cardiac than in skeletal muscle , and this apparent cooperativity requires the presence of troponin C on thin filament regulatory strands . Positive_regulation TMOD1 MYO16 10428784 633282 These results suggest that charged residues on the surface of the actin inner domain are important in Ca ( 2+ ) - and *induced* [thin filament] activation . Positive_regulation TMOD1 MYO16 10535949 562861 These results indicate that , in the presence of Tm , the strong binding of cooperatively *activates* the [thin filament] . Positive_regulation TMOD1 MYO16 10775487 686624 The aim of this study was to determine the length-dependence of mediated [thin filament] *activation* in skinned bovine ventricular muscle , as assayed by the generation of force with progressive reduction of MgATP concentration in the absence of Ca ( 2+ ) . Positive_regulation TMOD1 MYO16 11390938 822897 However , it is not muscle length but the lateral spacing between actin and myosin filaments that sets the level of Ca ( 2+ ) sensitivity , mainly through modulation of mediated *activation* of the [thin filament] . Positive_regulation TMOD1 MYO16 12545187 1028794 Inner sequences of tropomyosin , particularly actin binding periods 3 to 5 , play crucial role in induced *activation* of the [thin filament] . Positive_regulation TMOD1 MYO16 14507711 1145086 *Activation* of the calcium regulated [thin filament] by strong binding . Positive_regulation TMOD1 MYO16 15140746 1279566 Isoform switching from SM-B to SM-A *results* in decreased contractility and altered expression of [thin filament] regulatory proteins . Positive_regulation TMOD1 MYO16 17420299 1723802 However , other actions of these motors sustain sarcomeric activation by cooperative feedback mechanisms in which the interaction *promotes* [thin-filament] activation . Positive_regulation TMOD1 MYO16 18165684 1875387 We conclude that the highly conserved Asp-137 destabilizes the middle of Tm , resulting in a more flexible region that is important for the cooperative *activation* of the [thin filament] by . Positive_regulation TMOD1 MYO16 18985725 2015246 The data show that the [thin filament] is cooperatively *activated* by across regulatory units when Tm is phosphorylated . Positive_regulation TMOD1 MYO16 19799913 2195759 In conclusion , E99K inhibits the *activation* of the [thin filament] by strong binding whereas R312H demonstrates enhanced calcium activation . Positive_regulation TMOD1 MYO16 22749829 2639371 Ca ( 2+ ) -sensitivity of the actomyosin interactions , as well as cooperativity of induced *activation* of the [thin filament] was affected by individual tropomyosin mutants with various degrees . Positive_regulation TMOD1 MYO16 7787029 309994 The steepness of the tension-pMgATP relationship , between the region of the curve where tension was zero and the peak tension , is hypothesized to be due to induced cooperative *activation* of the [thin filament] . Positive_regulation TMOD1 MYO16 7787029 310006 The steeper slope in cardiac myocytes provides evidence of greater binding *induced* cooperative activation of the [thin filament] in cardiac as compared with skeletal muscle , at least under these experimental conditions of nominal free Ca2+ . Positive_regulation TMOD1 MYO16 7787029 310030 These results suggest that , in the absence of Ca2+ , *mediated* activation of the [thin filament] is greater in cardiac than in skeletal muscle , and this apparent cooperativity requires the presence of troponin C on thin filament regulatory strands . Positive_regulation TMOD1 MYO19 10428784 633281 These results suggest that charged residues on the surface of the actin inner domain are important in Ca ( 2+ ) - and *induced* [thin filament] activation . Positive_regulation TMOD1 MYO19 10535949 562860 These results indicate that , in the presence of Tm , the strong binding of cooperatively *activates* the [thin filament] . Positive_regulation TMOD1 MYO19 10775487 686623 The aim of this study was to determine the length-dependence of mediated [thin filament] *activation* in skinned bovine ventricular muscle , as assayed by the generation of force with progressive reduction of MgATP concentration in the absence of Ca ( 2+ ) . Positive_regulation TMOD1 MYO19 11390938 822896 However , it is not muscle length but the lateral spacing between actin and myosin filaments that sets the level of Ca ( 2+ ) sensitivity , mainly through modulation of *mediated* activation of the [thin filament] . Positive_regulation TMOD1 MYO19 12545187 1028793 Inner sequences of tropomyosin , particularly actin binding periods 3 to 5 , play crucial role in *induced* activation of the [thin filament] . Positive_regulation TMOD1 MYO19 14507711 1145085 *Activation* of the calcium regulated [thin filament] by strong binding . Positive_regulation TMOD1 MYO19 15140746 1279565 Isoform switching from SM-B to SM-A *results* in decreased contractility and altered expression of [thin filament] regulatory proteins . Positive_regulation TMOD1 MYO19 17420299 1723801 However , other actions of these motors sustain sarcomeric activation by cooperative feedback mechanisms in which the interaction *promotes* [thin-filament] activation . Positive_regulation TMOD1 MYO19 18165684 1875386 We conclude that the highly conserved Asp-137 destabilizes the middle of Tm , resulting in a more flexible region that is important for the cooperative *activation* of the [thin filament] by . Positive_regulation TMOD1 MYO19 18985725 2015245 The data show that the [thin filament] is cooperatively *activated* by across regulatory units when Tm is phosphorylated . Positive_regulation TMOD1 MYO19 19799913 2195758 In conclusion , E99K inhibits the *activation* of the [thin filament] by strong binding whereas R312H demonstrates enhanced calcium activation . Positive_regulation TMOD1 MYO19 22749829 2639370 Ca ( 2+ ) -sensitivity of the actomyosin interactions , as well as cooperativity of *induced* activation of the [thin filament] was affected by individual tropomyosin mutants with various degrees . Positive_regulation TMOD1 MYO19 7787029 309993 The steepness of the tension-pMgATP relationship , between the region of the curve where tension was zero and the peak tension , is hypothesized to be due to *induced* cooperative activation of the [thin filament] . Positive_regulation TMOD1 MYO19 7787029 310005 The steeper slope in cardiac myocytes provides evidence of greater binding *induced* cooperative activation of the [thin filament] in cardiac as compared with skeletal muscle , at least under these experimental conditions of nominal free Ca2+ . Positive_regulation TMOD1 MYO19 7787029 310029 These results suggest that , in the absence of Ca2+ , mediated *activation* of the [thin filament] is greater in cardiac than in skeletal muscle , and this apparent cooperativity requires the presence of troponin C on thin filament regulatory strands . Positive_regulation TMOD1 MYO6 10428784 633284 These results suggest that charged residues on the surface of the actin inner domain are important in Ca ( 2+ ) - and *induced* [thin filament] activation . Positive_regulation TMOD1 MYO6 10535949 562863 These results indicate that , in the presence of Tm , the strong binding of cooperatively *activates* the [thin filament] . Positive_regulation TMOD1 MYO6 10775487 686626 The aim of this study was to determine the length-dependence of mediated [thin filament] *activation* in skinned bovine ventricular muscle , as assayed by the generation of force with progressive reduction of MgATP concentration in the absence of Ca ( 2+ ) . Positive_regulation TMOD1 MYO6 11390938 822899 However , it is not muscle length but the lateral spacing between actin and myosin filaments that sets the level of Ca ( 2+ ) sensitivity , mainly through modulation of mediated *activation* of the [thin filament] . Positive_regulation TMOD1 MYO6 12545187 1028796 Inner sequences of tropomyosin , particularly actin binding periods 3 to 5 , play crucial role in induced *activation* of the [thin filament] . Positive_regulation TMOD1 MYO6 14507711 1145088 *Activation* of the calcium regulated [thin filament] by strong binding . Positive_regulation TMOD1 MYO6 15140746 1279568 Isoform switching from SM-B to SM-A *results* in decreased contractility and altered expression of [thin filament] regulatory proteins . Positive_regulation TMOD1 MYO6 17420299 1723804 However , other actions of these motors sustain sarcomeric activation by cooperative feedback mechanisms in which the interaction *promotes* [thin-filament] activation . Positive_regulation TMOD1 MYO6 18165684 1875389 We conclude that the highly conserved Asp-137 destabilizes the middle of Tm , resulting in a more flexible region that is important for the cooperative *activation* of the [thin filament] by . Positive_regulation TMOD1 MYO6 18985725 2015248 The data show that the [thin filament] is cooperatively *activated* by across regulatory units when Tm is phosphorylated . Positive_regulation TMOD1 MYO6 19799913 2195761 In conclusion , E99K inhibits the *activation* of the [thin filament] by strong binding whereas R312H demonstrates enhanced calcium activation . Positive_regulation TMOD1 MYO6 22749829 2639373 Ca ( 2+ ) -sensitivity of the actomyosin interactions , as well as cooperativity of *induced* activation of the [thin filament] was affected by individual tropomyosin mutants with various degrees . Positive_regulation TMOD1 MYO6 7787029 309996 The steepness of the tension-pMgATP relationship , between the region of the curve where tension was zero and the peak tension , is hypothesized to be due to induced cooperative *activation* of the [thin filament] . Positive_regulation TMOD1 MYO6 7787029 310008 The steeper slope in cardiac myocytes provides evidence of greater binding *induced* cooperative activation of the [thin filament] in cardiac as compared with skeletal muscle , at least under these experimental conditions of nominal free Ca2+ . Positive_regulation TMOD1 MYO6 7787029 310032 These results suggest that , in the absence of Ca2+ , *mediated* activation of the [thin filament] is greater in cardiac than in skeletal muscle , and this apparent cooperativity requires the presence of troponin C on thin filament regulatory strands . Positive_regulation TMOD1 NEB 19736309 2158303 Our findings indicate the following : 1 ) in skeletal muscle *increases* [thin filament] activation , and 2 ) through altering cross-bridge cycling kinetics , nebulin increases force and efficiency of contraction . Positive_regulation TMOD1 PRKCA 12419997 1013363 Activation of by EGF *causes* an increased phosphorylation of [tropomodulin] which results in an increase in tropomodulin association with cytoskeletal components . Positive_regulation TMOD1 TMOD1 12975349 1139819 These studies indicate that the interaction of with tropomyosin is *critical* for [thin filament] stability . Positive_regulation TMOD1 TPM1 10574928 569234 When the affinity of [tropomodulin] for pointed ends was *increased* about 1000-fold by the presence of ( K ( d ) < 0.05 nM ) , capping of 95 % of the ends by tropomodulin did not alter the critical concentration . Positive_regulation TMOD1 TPM1 12975349 1139820 These studies indicate that the interaction of Tmod1 with is *critical* for [thin filament] stability . Positive_regulation TMOD1 TPM1 14870966 1182541 The implications of these findings for the *role* of in [thin filament] regulation are discussed . Positive_regulation TMOD1 TPM1 23662437 2714311 In striated muscle , the actin [thin filament] is *regulated* by the complex . Positive_regulation TMOD1 TPM1 3595858 75505 Since the [thin filament] regulation of smooth muscle contraction by caldesmon *requires* the presence of , these results suggest that the direct interaction between tropomyosin and caldesmon on the thin filament plays a role in this regulation . Positive_regulation TMOD1 TPM1 7730404 302294 Mechanisms of thin filament assembly in embryonic chick cardiac myocytes : [tropomodulin] *requires* for assembly . Positive_regulation TMOD1 TPM1 8509369 221589 The essential *role* of in cooperative regulation of smooth muscle [thin filament] activity by caldesmon . Positive_regulation TMOD1 TPM1 9210222 441173 Unlike proteins that cap actin filament barbed ends , [tropomodulin] also binds tropomyosin and *requires* for tight capping of actin filament pointed ends . Positive_regulation TMOD1 TPM1 9894007 586792 [Thin filament] regulation is *mediated* by the presence of and troponin ( Tn ) on the actin filament . Positive_regulation TMOD1 TPM2 10574928 569235 When the affinity of [tropomodulin] for pointed ends was *increased* about 1000-fold by the presence of ( K ( d ) < 0.05 nM ) , capping of 95 % of the ends by tropomodulin did not alter the critical concentration . Positive_regulation TMOD1 TPM2 12975349 1139821 These studies indicate that the interaction of Tmod1 with is *critical* for [thin filament] stability . Positive_regulation TMOD1 TPM2 14870966 1182542 The implications of these findings for the *role* of in [thin filament] regulation are discussed . Positive_regulation TMOD1 TPM2 23662437 2714312 In striated muscle , the actin [thin filament] is *regulated* by the complex . Positive_regulation TMOD1 TPM2 3595858 75506 Since the [thin filament] regulation of smooth muscle contraction by caldesmon *requires* the presence of , these results suggest that the direct interaction between tropomyosin and caldesmon on the thin filament plays a role in this regulation . Positive_regulation TMOD1 TPM2 7730404 302295 Mechanisms of thin filament assembly in embryonic chick cardiac myocytes : [tropomodulin] *requires* for assembly . Positive_regulation TMOD1 TPM2 8509369 221590 The essential *role* of in cooperative regulation of smooth muscle [thin filament] activity by caldesmon . Positive_regulation TMOD1 TPM2 9210222 441174 Unlike proteins that cap actin filament barbed ends , [tropomodulin] also binds tropomyosin and *requires* for tight capping of actin filament pointed ends . Positive_regulation TMOD1 TPM2 9894007 586793 [Thin filament] regulation is *mediated* by the presence of and troponin ( Tn ) on the actin filament . Positive_regulation TMOD1 TPM3 10574928 569236 When the affinity of [tropomodulin] for pointed ends was *increased* about 1000-fold by the presence of ( K ( d ) < 0.05 nM ) , capping of 95 % of the ends by tropomodulin did not alter the critical concentration . Positive_regulation TMOD1 TPM3 12975349 1139822 These studies indicate that the interaction of Tmod1 with is *critical* for [thin filament] stability . Positive_regulation TMOD1 TPM3 14870966 1182543 The implications of these findings for the *role* of in [thin filament] regulation are discussed . Positive_regulation TMOD1 TPM3 23662437 2714313 In striated muscle , the actin [thin filament] is *regulated* by the complex . Positive_regulation TMOD1 TPM3 3595858 75507 Since the [thin filament] regulation of smooth muscle contraction by caldesmon *requires* the presence of , these results suggest that the direct interaction between tropomyosin and caldesmon on the thin filament plays a role in this regulation . Positive_regulation TMOD1 TPM3 7730404 302296 Mechanisms of thin filament assembly in embryonic chick cardiac myocytes : [tropomodulin] *requires* for assembly . Positive_regulation TMOD1 TPM3 8509369 221591 The essential *role* of in cooperative regulation of smooth muscle [thin filament] activity by caldesmon . Positive_regulation TMOD1 TPM3 9210222 441175 Unlike proteins that cap actin filament barbed ends , [tropomodulin] also binds tropomyosin and *requires* for tight capping of actin filament pointed ends . Positive_regulation TMOD1 TPM3 9894007 586794 [Thin filament] regulation is *mediated* by the presence of and troponin ( Tn ) on the actin filament . Positive_regulation TMOD1 TPM4 10574928 569237 When the affinity of [tropomodulin] for pointed ends was *increased* about 1000-fold by the presence of ( K ( d ) < 0.05 nM ) , capping of 95 % of the ends by tropomodulin did not alter the critical concentration . Positive_regulation TMOD1 TPM4 12975349 1139823 These studies indicate that the interaction of Tmod1 with is *critical* for [thin filament] stability . Positive_regulation TMOD1 TPM4 14870966 1182544 The implications of these findings for the *role* of in [thin filament] regulation are discussed . Positive_regulation TMOD1 TPM4 23662437 2714314 In striated muscle , the actin [thin filament] is *regulated* by the complex . Positive_regulation TMOD1 TPM4 3595858 75508 Since the [thin filament] regulation of smooth muscle contraction by caldesmon *requires* the presence of , these results suggest that the direct interaction between tropomyosin and caldesmon on the thin filament plays a role in this regulation . Positive_regulation TMOD1 TPM4 7730404 302297 Mechanisms of thin filament assembly in embryonic chick cardiac myocytes : [tropomodulin] *requires* for assembly . Positive_regulation TMOD1 TPM4 8509369 221592 The essential *role* of in cooperative regulation of smooth muscle [thin filament] activity by caldesmon . Positive_regulation TMOD1 TPM4 9210222 441176 Unlike proteins that cap actin filament barbed ends , [tropomodulin] also binds tropomyosin and *requires* for tight capping of actin filament pointed ends . Positive_regulation TMOD1 TPM4 9894007 586795 [Thin filament] regulation is *mediated* by the presence of and troponin ( Tn ) on the actin filament . Positive_regulation TMOD1 WNT5A 17904105 1803089 We found that [Tmod1] , known as an actin capping protein , is *up-regulated* by , while gelsolin , known as an actin severing protein , is down-regulated by Wnt5a . Positive_regulation TMPRSS4 CDH1 21637307 2464605 Whereas , 30 days after radiation , when the expression of MMP-2 and VEGF decreased to unirradiated control levels , the in vivo dissemination and metastatic potential of residual tumors have just begun to increase with overexpression of [TMPRSS4] , which *induced* loss of through induction of Smad Interacting E-cadherinein 1 (SIP1) , an epithelial-mesenchymal transition (EMT) transcriptional repressor , and led to TMPRSS4 . Positive_regulation TMPRSS4 MORF4L1 23821596 2834520 In cultured cells , we show that levels of chromatin bound [Cap-H2] protein are partially dependent on Mrg15 and that Cap-H2 mediated homolog unpairing is *suppressed* by RNA interference depletion of . Positive_regulation TMPRSS4 PLAU 23978400 2888032 Here , we demonstrated that [TMPRSS4] induced the transcription of the urokinase-type plasminogen activator ( uPA ) gene through activating the transcription factors Sp1 , Sp3 , and AP-1 in mainly a JNK dependent manner and that the induction of was *required* for TMPRSS4 mediated cancer cell invasion and signaling events . Positive_regulation TNC CTGF 12217862 986375 HTEC expression of [tenascin-C (TN-C)] was *increased* by TGF-beta and , although TGF-beta was the more potent inducer . Positive_regulation TNC TNF 14734780 1199523 Ets-1 regulates *induced* matrix metalloproteinase-9 and [tenascin] expression in primary bronchial fibroblasts . Positive_regulation TNC TNF 15592496 1375242 Since preinflammatory cytokines also act through p38MAPK and JNK signaling pathways , the possible *role* of in [tenascin-W] expression was also examined . Positive_regulation TNC TNF 15592496 1375245 *induced* the expression of both [tenascin-W] and tenascin-C , and this induction was p38MAPK- and cyclooxygenase dependent . Positive_regulation TNC TNF 18061975 1853621 *stimulated* [tenascin-C] expression through NF-kappaB signaling with RelA activation in cultured OA chondrocytes , suggesting involvement of tenascin-C in OA cartilage remodeling . Positive_regulation TNC TNF 21205293 2379135 The expression of tenascin-C in the lungs of OVA challenged STAT4-/- mice was weaker than in those of OVA challenged WT and STAT6-/- mice suggesting that and IFN-? may *regulate* [tenascin-C] expression in vivo . Positive_regulation TNC TNF 21205293 2379137 The stimulation of human fibroblasts with and IFN-? *induced* the expression of [tenascin-C] confirming our in vivo findings . Positive_regulation TNF A2M 1704186 152734 alpha 2M-plasmin or alpha 2M-methylamine added to human plasma or serum preferentially bound [125I-TNF-alpha] in the *presence* of native . Positive_regulation TNF ABCA1 16492740 1535156 [TNFalpha] *induces* through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells . Positive_regulation TNF ABCC1 22290395 2617479 Furthermore , [tumor necrosis factor-a] and transforming growth factor-ß1 *induced* the expression of Lpcat2/4 and and down-regulated Slc10a1 and Slco1a1 in primary hepatocytes , suggesting an association between the changes in serum LPC and bile acids and proinflammatory cytokines . Positive_regulation TNF ABCC4 22290395 2617480 Furthermore , [tumor necrosis factor-a] and transforming growth factor-ß1 *induced* the expression of Lpcat2/4 and and down-regulated Slc10a1 and Slco1a1 in primary hepatocytes , suggesting an association between the changes in serum LPC and bile acids and proinflammatory cytokines . Positive_regulation TNF ABCD1 24400890 2906984 is related to enhanced gut permeability that allows the levels of LPS to increase , *leads* to increased secretion of [TNF-a] by the Kupffer cells and subsequently promotes alcoholic liver injury through specific miRNAs . Positive_regulation TNF ABCG2 20846001 2375384 In conclusion , interleukin-1ß and [tumor necrosis factor-a] *induced* and PXR mRNAs in the MCF7 breast cancer cell line ; Positive_regulation TNF ABCG2 22750628 2659713 In conclusion , IL-1ß and [TNF-a] *induced* and PXR expression and NF-?B activity in some breast cancer and normal cell lines . Positive_regulation TNF ABL1 9531291 496800 In this study , we showed that reduction of in macrophages *prevented* LPS induced growth arrest , nitric oxide production and [TNF-alpha] secretion by ANA-1 macrophages . Positive_regulation TNF ACAT1 15699266 1372522 Systemic inhibition *reduces* circulating [tumor necrosis factor-alpha] levels in hypercholesterolemic subjects and improves resistance-vessel endothelial function , with small effects on circulating cholesterol . Positive_regulation TNF ACD 11067865 747002 Isolated hepatocytes treated with [TNF-alpha] in the *presence* of the transcription inhibitor accumulated cat B in their cytosol . Positive_regulation TNF ACD 9386984 466435 These findings suggest that systemic [TNF alpha] or IL-1 beta are not involved in the erythropoietin *response* to . Positive_regulation TNF ACE 15353612 1353843 In parallel human in vitro experiments , inhibition *suppressed* LPS stimulated production of [TNF-alpha] by monocytes . Positive_regulation TNF ACE 19073907 2024165 Inhibition of T-cell *reduced* [TNF-alpha] production , indicating endogenously produced ANG II has a regulatory role in this process . Positive_regulation TNF ACE 19537595 2098979 Much attention is paid to perspectives of inhibitors , angiotensin II receptor blockers , statins , [TNFalpha] *inhibitors* in prevention of cardiovascular complication in RA Positive_regulation TNF ACE2 19411314 2095741 Phorbol ester , ionomycin , endotoxin , and IL-1beta and [TNFalpha] acutely *induced* release , further supporting that ADAM17 and ADAM10 regulate ACE2 cleavage . Positive_regulation TNF ACPP 20396928 2315331 treatment *induced* a 3.6 , 2.8 , 13.0 , 3.5 fold induction of IL-1alpha , IL-1beta , [TNF-alpha] and IL-6 , respectively ; Positive_regulation TNF ACSM3 19201949 2033901 These data identify an essential role for tnfa in the mutant phenotype and suggest a direct link between *induced* methylation defects and [TNF] expression in human liver disorders associated with elevated TNFalpha . Positive_regulation TNF ACSM3 22621234 2632455 *caused* the increase ofn PMNs chemiluminescence as well as the increase of production of ET-1 and [TNF-a] by MNs but had no influence on IL-6 concentration . Positive_regulation TNF ACSM3 23895491 2825698 *resulted* in increased levels of plasma [tumour necrosis factor (TNF)-a] , interleukin (IL)-1ß , IL-6 levels and caspase-3 activity . Positive_regulation TNF ACTB 7945348 276520 However , production of NO did not affect the expression of both [TNF-alpha] and TGF-beta gene which were *induced* by the stimulation of macrophages , as well as gene , which was constitutively expressed in the macrophages . Positive_regulation TNF ADA 16860713 1588834 These drugs caused a marked reduction in MPO activity , as well as IL-1beta and [TNFalpha] levels ( P < 0.01 ) , but only Tacrolimus *inhibited* activity ( P < 0.01 ) . Positive_regulation TNF ADA 19703146 2133355 *stimulated* [TNF-alpha] production was proportional to parity and unrelated to gestational age , time of delivery , maternal age or indication for amniocentesis . Positive_regulation TNF ADAM10 18981120 1983397 Tetraspanins regulate *mediated* cleavage of [TNF-alpha] and epidermal growth factor . Positive_regulation TNF ADAM11 17617471 1769552 TNF-alpha generated *increased* the expression of a distinctly different panel of cytokines , namely IL-2 , IL-4 , IL-12p40 , IL-13 , [TNF-alpha] , TGF-beta , IFN-gamma , and MCP-2 , and shifted naïve T cell differentiation to T helper cell type 2 ( Th2 ) polarization . Positive_regulation TNF ADAM11 23338235 2743047 In contrast to pDC and monocytes/macrophages , *increased* [TNF-a] production in response to stimulation following acute infection . Positive_regulation TNF ADAM17 11406201 825717 TACE enzymatic activity from OGD exposed slices was significantly inhibited by cycloheximide , suggesting that de novo synthesis of *contributes* to [TNF-alpha] release after ischaemia . Positive_regulation TNF ADAM17 11406201 825718 Taken together , these data demonstrate that ( 1 ) TACE/ADAM17 activity accounts for the majority of TNF-alpha shedding after OGD in rat forebrain slices , ( 2 ) an increase in expression *contributes* , at least in part , to the rise in [TNF-alpha] after OGD and ( 3 ) iNOS expression in OGD subjected brain slices results from TACE activity and subsequent increase in TNF-alpha levels . Positive_regulation TNF ADAM17 11508576 848155 A synthetic inhibitor significantly *reduced* the release of [TNF-alpha] and p75 TNF receptor from RA ST cells . Positive_regulation TNF ADAM17 11973430 934293 Taken together , these data demonstrate that , in rat mixed neuronal-glial cortical cultures exposed to OGD or glutamate , ( 1 ) TACE/ADAM17 activity accounts for the majority of TNF-alpha shedding , ( 2 ) an increase in glial expression *contributes* to the rise in [TNF-alpha] , and ( 3 ) TNF-alpha release in this setting inhibits apoptosis via activation of the transcription factor NF-kappaB . Positive_regulation TNF ADAM17 12646554 1091984 Histamine induced shedding is blocked by [TNF-alpha] protease *inhibitor* , an inhibitor of , and through the H1 receptor via a MEK-1/p42 and p44 mitogen activated protein kinase pathway . Positive_regulation TNF ADAM17 15292243 1302963 Our results corroborate that , but not ADAM9 , -10 , or -19 , is *critical* for phorbol ester- and pervanadate stimulated release of [TNFalpha] in mouse embryonic fibroblasts . Positive_regulation TNF ADAM17 15365312 1294643 We hypothesized that chronic ethanol through oxidative stress activates *mediated* ectodomain shedding of the preformed substrates p75 and p55 [TNF] receptors in Mono Mac 6 cells and L-selectin in Jurkat T cells . Positive_regulation TNF ADAM17 16273118 1502451 Human colonic myocytes are involved in postischemic inflammation through *dependent* [TNFalpha] production . Positive_regulation TNF ADAM17 16294222 1484668 Unchecked activity *causes* an increase in levels of soluble [TNF-alpha] , which subsequently promotes diabetes and vascular inflammation . Positive_regulation TNF ADAM17 17264149 1696911 In addition , conditioned medium from stretched myoblast cultures activated p38 in unstretched myoblasts , which *required* activity in the donor myoblasts , and [TNF-alpha] receptors in the recipient myoblasts . Positive_regulation TNF ADAM17 17786981 1842747 HDLs reduced the cholesterol and proteins ( including ADAM17 ) content of lipid rafts and triggered the *dependent* cleavage of [TNF] in the non-raft region of the membrane . Positive_regulation TNF ADAM17 18187448 1856715 Therefore , although activity per se is not *required* for the LPS stimulated cell surface expression of [pre-TNF alpha] , the phosphorylation of this protease might contribute to , or be required for , the cell surface expression of the pre-TNF alpha-TACE complex . Positive_regulation TNF ADAM17 18383040 1893003 In the presence of IL-10 , [TNF-alpha] production and *activation* of surface was significantly inhibited . Positive_regulation TNF ADAM17 18490652 1921791 Modulation of by the spike protein of SARS-CoV and ACE2 *induces* [TNF-alpha] production and facilitates viral entry . Positive_regulation TNF ADAM17 19082505 2018331 [TNF-alpha] production and the bioavailability of its receptors on the cell surface are *regulated* by ( TNF-alpha converting enzyme ) , a pleiotropic metalloprotease also known as ADAM17 , and its specific inhibitor TIMP3 . Positive_regulation TNF ADAM17 19167455 2038617 Since is *involved* not only in degradation of cell-matrix adhesion structures , but also in ectodomain shedding of ligands for epidermal growth factor receptor (EGFR) and in release of [TNFalpha] , these results imply TACE mediated pathways as a new concept in HD toxicity . Positive_regulation TNF ADAM17 19299578 2080083 [TNF-alpha] *induced* an early upregulation of in T84 cells , whereas PMNL adhesion , H ( 2 ) O ( 2 ) , or epithelial tight junction opening alone did not affect the amount of ADAM17 . Positive_regulation TNF ADAM17 19854762 2165490 Our study demonstrated a dose dependent increase of TACE messenger RNA ( mRNA ) expression in anti-Ro/SSA Abs treated SGEC , followed by internalization , pro-domain shedding and activation of TACE protein , suggesting that increased activity is *necessary* for the release of [TNF-alpha] observed in anti-Ro/SSA Abs stimulated SGEC . Positive_regulation TNF ADAM17 20061048 2319492 Anti-Ro/SSA autoAbs determines TACE pro-domain shedding suggesting that activity is *necessary* for the release of [TNF-a] observed in anti-Ro/SSA autoAbs stimulated cells . Positive_regulation TNF ADAM17 23297114 2780633 Hydrogen sulfide reduces cell adhesion and relevant inflammatory triggering by preventing *dependent* [TNF-a] activation . Positive_regulation TNF ADAM17 23297114 2780634 In addition , H2S significantly reduces activation of ADAM17 by PMA in endothelial cells , with consequent reduction of both *dependent* [TNF-a] ectodomain shedding and MCP-1 release . Positive_regulation TNF ADAM17 23639813 2805086 We conclude that *regulates* [TNF] , TNFR1 , and AR in the liver , and its expression in both hepatocytes and myeloid cells is important for TNF regulation after LPS injury or 2/3 PH , but is not required for liver regeneration . Positive_regulation TNF ADAM17 9845404 553421 Agents that prevent TNFalpha mRNA transcription , e.g. lisophylline , PGE2 , interleukin-10 and 8-BrcAMP , or inhibitors , e.g. EDTA , TAPI-2 and BB-3103 , *inhibit* [TNFalpha] release and protect rats against gastric mucosal injury induced by oral administration of aspirin . Positive_regulation TNF ADAM8 11050116 743327 In primary astrocytes from wild-type and WR mice , in primary cerebellar neurons , and in mouse motoneuron-like NSC19 cells , expression was *induced* up to 15-fold by mouse [TNF-alpha] , in a dose dependent manner . Positive_regulation TNF ADAM8 20826683 2318786 Our results indicate an essential *role* for in modulating [TNF-alpha] signaling in CNS diseases : a feedback loop integrating TNF-alpha , ADAM8 , and TNF-R1 shedding as a plausible mechanism for TNF-alpha mediated neuroprotection in situ and a rationale for therapeutic intervention . Positive_regulation TNF ADAM9 15292243 1302964 Our results corroborate that ADAM17 , but not , -10 , or -19 , is *critical* for phorbol ester- and pervanadate stimulated release of [TNFalpha] in mouse embryonic fibroblasts . Positive_regulation TNF ADAMTS12 18485748 1971687 The suppression of ADAMTS-7 or expression by siRNA silencing in the human chondrocytes also *prevented* [TNF-alpha-] or IL-1beta induced COMP degradation . Positive_regulation TNF ADAMTS4 24126638 2858873 [Tumor necrosis factor-a] *induces* expression in human osteoarthritis chondrocytes . Positive_regulation TNF ADAMTS4 24126638 2858878 [TNF-a] *induces* expression and activity in human osteoarthritic chondrocytes at the transcriptional level via TNFR1 by a p38 MAPK dependent mechanism . Positive_regulation TNF ADAMTS7 18485748 1971688 The suppression of or ADAMTS-12 expression by siRNA silencing in the human chondrocytes also *prevented* [TNF-alpha-] or IL-1beta induced COMP degradation . Positive_regulation TNF ADAMTS7 23928557 2942224 in addition , [TNF-a] *induced* through NF-?B signalling . Positive_regulation TNF ADAMTS9 15883123 1464972 [TNFalpha] alone *induced* expression , whereas OSM addition caused suppression . Positive_regulation TNF ADCY1 7683159 216407 activator , forskolin ( FK ) , at 100 microM also significantly augmented HIV production ( > 4-fold ) and *potentiated* [TNF] induction in J22HL-60 and U1 cells . Positive_regulation TNF ADCY10 7683159 216406 activator , forskolin ( FK ) , at 100 microM also significantly augmented HIV production ( > 4-fold ) and *potentiated* [TNF] induction in J22HL-60 and U1 cells . Positive_regulation TNF ADCY2 7683159 216408 activator , forskolin ( FK ) , at 100 microM also significantly augmented HIV production ( > 4-fold ) and *potentiated* [TNF] induction in J22HL-60 and U1 cells . Positive_regulation TNF ADCY3 7683159 216409 activator , forskolin ( FK ) , at 100 microM also significantly augmented HIV production ( > 4-fold ) and *potentiated* [TNF] induction in J22HL-60 and U1 cells . Positive_regulation TNF ADCY4 7683159 216410 activator , forskolin ( FK ) , at 100 microM also significantly augmented HIV production ( > 4-fold ) and *potentiated* [TNF] induction in J22HL-60 and U1 cells . Positive_regulation TNF ADCY5 7683159 216411 activator , forskolin ( FK ) , at 100 microM also significantly augmented HIV production ( > 4-fold ) and *potentiated* [TNF] induction in J22HL-60 and U1 cells . Positive_regulation TNF ADCY6 7683159 216412 activator , forskolin ( FK ) , at 100 microM also significantly augmented HIV production ( > 4-fold ) and *potentiated* [TNF] induction in J22HL-60 and U1 cells . Positive_regulation TNF ADCY7 7683159 216413 activator , forskolin ( FK ) , at 100 microM also significantly augmented HIV production ( > 4-fold ) and *potentiated* [TNF] induction in J22HL-60 and U1 cells . Positive_regulation TNF ADCY8 7683159 216414 activator , forskolin ( FK ) , at 100 microM also significantly augmented HIV production ( > 4-fold ) and *potentiated* [TNF] induction in J22HL-60 and U1 cells . Positive_regulation TNF ADCY9 7683159 216415 activator , forskolin ( FK ) , at 100 microM also significantly augmented HIV production ( > 4-fold ) and *potentiated* [TNF] induction in J22HL-60 and U1 cells . Positive_regulation TNF ADIPOQ 12974762 1139773 However , also negatively *regulates* [TNF-alpha] levels . Positive_regulation TNF ADIPOQ 15905315 1426880 however , leptin at 100 ng/ml and at 0.1 and/or 0.5 microg/ml significantly *increased* the release of IL-1beta , IL-6 , [TNFalpha] , and PGE2 from human placenta and adipose tissue . Positive_regulation TNF ADIPOQ 16115611 1448895 Here , we provide experimental evidence that the `` anti-inflammatory '' effect of adiponectin may be due to an induction of macrophage tolerance : globular ( gAd ) is a powerful *inducer* of [TNF-alpha] and IL-6 secretion in primary human peripheral macrophages , in the THP-1 human macrophage cell line , and in primary mouse peritoneal macrophages . Positive_regulation TNF ADIPOQ 16814613 1591325 levels *increased* from 3.7 to 10.3 mug/mL at week 48 ( P < .01 ) ; the levels of the other cytokines were unchanged : [TNF-alpha] , 9.1 vs 8.8 pg/mL ; IL-1a , 3.9 vs 3.4 pg/mL ; IL-6 , 19.4 vs 13.4 pg/mL ; and leptin , 24.8 vs 29.6 ng/mL ( P > .05 for all ) . Positive_regulation TNF ADIPOQ 17062358 1637248 In the 150 and 450 mg/kg SIF groups , fasting body-weights , visceral adipose tissue deposition , FINS , resistin , [TNF-alpha] in serum , and IR index were lowered in comparison with the model control group , and in 450 mg/kg SIF group , serum IL-6 level was obviously lowered , and *increased* . Positive_regulation TNF ADIPOQ 17080243 1654922 the mRNA expression of [TNF-alpha] , TGF-beta(1) , and type I procollagen decreased , but the expression of *increased* significantly , compared with that in the model group . Positive_regulation TNF ADIPOQ 17537727 1767287 Here we demonstrate that globular ( gAcrp ) initially *increased* [TNF-alpha] expression in RAW264.7 macrophages ; Positive_regulation TNF ADIPOQ 17537727 1767294 In summary , these data demonstrate that initially *increases* [TNF-alpha] production by macrophages via ERK1/2 -- > Egr-1 and NFkappaB dependent mechanisms ; Positive_regulation TNF ADIPOQ 19617629 2131178 A systematic search for adiponectin-inducible genes with established anti-inflammatory properties revealed that *augmented* the expression of A20 , suppressor of cytokine signaling (SOCS) 3 , B-cell CLL/lymphoma (BCL) 3 , [TNF receptor associated factor (TRAF)] 1 , and TNFAIP3 interacting protein (TNIP) 3 . Positive_regulation TNF ADIPOQ 20376096 2266840 The anti-steatohepatitis action of PPARgamma was also mediated via regulating adipokines through suppressing [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-6 (IL-6) and *inducing* . Positive_regulation TNF ADIPOQ 22571939 2619224 Accumulative studies have shown that there exists a reciprocal relationship between adiponectin and TNF-a , i.e. , negatively *regulates* [TNF-a] expression , whereas adiponectin expression is inhibited by TNF-a . Positive_regulation TNF ADM 23918941 2826094 Both RANTES and [TNF] *induce* through activation of nuclear factor ?B and its target genes involved in regulating survival , proliferation , and degradation of extracellular matrix . Positive_regulation TNF ADORA1 11357956 815994 Previously , we have reported that the ( A1AR ) *regulates* [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-6 (IL-6) expression and exhibits diminished function in patients with multiple sclerosis ( MS ; Positive_regulation TNF ADORA1 15748700 1379389 The *role* of and A2B receptors in the regulation of [TNF-alpha] production by human monocytes . Positive_regulation TNF ADORA2B 22531331 2602558 Pharmacologic studies on human activated PMNs revealed an *dependent* [tumor necrosis factor] a release . Positive_regulation TNF ADORA3 15748700 1379390 The *role* of and A2B receptors in the regulation of [TNF-alpha] production by human monocytes . Positive_regulation TNF ADRB2 11096136 755710 activation *regulates* [tumour necrosis factor (TNF)-alpha] and interleukin-6 (IL-6) production in cultured renal cells . Positive_regulation TNF ADRB2 11675405 873342 It is likely that cAMP-PKA and MAPK ( p42/p44 , p38 ) may *play* a critical role in the regulation of the Stx-2 induced [TNF-alpha] transcription via activation . Positive_regulation TNF AGA 23685153 2805883 To determine the role of ADA2 , we found that *induces* ADA2 expression , ADA2 activity and [TNF-a] release , and that TNF-a release is blocked by ADA2 neutralizing antibody or ADA2 siRNA , but not by scrambled siRNA . Positive_regulation TNF AGO2 11202234 763431 Data for *induced* [TNF-alpha] release for this subgroup were also significant ( P < 0.001 and P < 0.05 , respectively ) . Positive_regulation TNF AGO2 12951895 1137391 *induced* IFN-gamma and [TNF-alpha] responses of cells from vaccinated calves and adults were greater than responses of autologous unstimulated cells . Positive_regulation TNF AGO2 16160917 1456078 The analysis of cytokine production using specific inhibitors of the MAPK pathway revealed that both p38 and ERK activation are essential for *induced* [TNF-alpha] production , whereas p38 , but not ERK , activation is essential for IL-10 secretion . Positive_regulation TNF AGO2 21791141 2546644 For TNF-a - 238 , there was a tendency towards an increase in *stimulated* [TNF-a] production after VAS for the G homozygotes , but the opposite tendency for A allele carriers ( Pinteraction = 0·07 ) . Positive_regulation TNF AGO2 23455702 2818562 and LPS significantly *increased* IL-6 , IL-10 , and [TNF-a] production in PBMCs . Positive_regulation TNF AGO2 7721344 301494 and rTNF when added singly *induced* [TNF-mRNA] accumulation in monocytes . Positive_regulation TNF AGO2 8622912 354611 Stimulation with and the 30-kDa alpha antigen of MTB ( 30-kDa antigen ) *induced* greater secretion of transforming growth factor beta ( TGF-beta ) , but not interleukin 10 (IL-10) or [tumor necrosis factor alpha (TNF-alpha)] , by PBMCs from TB patients compared to healthy contacts . Positive_regulation TNF AGO2 9731066 530428 Furthermore , *induced* [tumor necrosis factor (TNF)] release from monocytes through interactions with CD14 and , importantly , the addition of sCD14 enhanced this MAC-PPD stimulatory effect . Positive_regulation TNF AGPS 22212104 2624083 purified from kanuka honey *stimulated* the release of [TNF-a] from THP-1 and U937 cells . Positive_regulation TNF AGTR1 10905462 713686 Two of the dressings , Seasorb and Tegagen , had a minimal effect whilst Sorbsan mg/ml *induced* 302 + 19 pg/ml [TNFalpha] . Positive_regulation TNF AGTR1 2240164 144738 Endotoxin ( Salmonella typhus lipopolysaccharide ) injected intravenously *induces* little or no increase in whole-organ [TNF] mRNA levels at 15 ' , 30 ' , 1 degree , 2 degrees , or 4 degrees , whereas serum TNF levels are markedly elevated and 2 hours . Positive_regulation TNF AGTR1 23856402 2834969 However , CFA *induced* an increase of approximately 338 % in intracellular [TNF-a] , while release of this proinflammatory cytokine was increased by 1.6-fold . Positive_regulation TNF AGTR1 8228252 235734 Colchicine and 10 microM *stimulated* the production of both soluble [TNF/LT] receptors , but the PMA induced release of both soluble TNF/LT receptors was inhibited . Positive_regulation TNF AGTR2 17884764 1797363 receptors are *involved* in [alpha-TNF] and IL1 beta secretions in cardiac fibroblasts . Positive_regulation TNF AGTR2 18651847 1967040 h , minocycline HCl *induced* high levels of IL-10 , [TNFalpha] and IFNgamma , while CHX reduced the levels of TNFalpha and IFNgamma . Positive_regulation TNF AHR 24565903 2924692 [TNF-a] significantly *induced* along with CYP1A1 and CYP1B1 expression . Positive_regulation TNF AHSA1 15592496 1375209 Tenascin-W is found in malignant mammary tumors , promotes alpha8 integrin dependent motility and *requires* activity for BMP-2 and [TNF-alpha] induced expression in vitro . Positive_regulation TNF AHSA1 16297883 1502765 Dioscorin also stimulated multiple signaling molecules ( NF-kappaB , ERK , JNK , and ) and *induced* the expression of cytokines ( [TNF-alpha] , IL-1beta , and IL-6 ) in murine RAW 264.7 macrophages . Positive_regulation TNF AHSA1 20083499 2380886 For the first time , we show that , in fish macrophages , [TNF-a] is processed by TACE-like activity and this cleavage is *dependent* upon the activation of ERK , and JNK signaling pathways by LPS . Positive_regulation TNF AHSA1 23557259 2777797 Inhibition of and CD137 signaling *reduce* dengue virus induced [TNF-a] secretion and apoptosis . Positive_regulation TNF AHSG 18335040 1881505 treatment *induced* [TNF] and IL1B mRNA expression in THP1 cells ( p < 0.05 ) . Positive_regulation TNF AIMP1 22767513 2696984 We found that downregulation of CD23 attenuated *induced* [TNF-a] secretion and AIMP1 binding to THP-1 and PBMCs . Positive_regulation TNF AIMP1 22767513 2696988 We also observed that in THP-1 and PBMCs , *induced* [TNF-a] secretion , mediated by CD23 , involved activation of ERK1/2 . Positive_regulation TNF AIMP2 19584093 2111675 These findings suggest that can *mediate* the pro-apoptotic activity of [TNFalpha] via the downregulation of TRAF2 expression . Positive_regulation TNF AKR1B1 17030682 1634443 The results of the present study show that pharmacological inhibition of by sorbinil or knockdown of the enzyme by small interfering RNA *prevents* the activation of nuclear factor-kappaB and the release of [tumor necrosis factor-alpha] from lipopolysaccharide stimulated RAW264.7 or H9c2 cells . Positive_regulation TNF AKT1 10485710 644526 Thus , both and NIK are *necessary* for [TNF] activation of NF-kappaB . Positive_regulation TNF AKT1 10655266 663521 The *role* of and mitogen activated protein kinase in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Positive_regulation TNF AKT1 10974038 729197 in turn can *regulate* positively the transcriptional activity of interleukin (IL)-2 and [tumor necrosis factor (TNF)-alpha] promoters . Positive_regulation TNF AKT1 10974038 729209 Importantly , *regulates* the production and secretion of IL-2 and [TNF-alpha] in FcepsilonRI stimulated mast cells . Positive_regulation TNF AKT1 10984605 732215 The present study investigates the *role* of in the activation of NF-kappa B by [tumor necrosis factor-alpha] ( TNF alpha , 10 ng/ml ) and PDGF-BB ( 20 ng/ml ) in human vascular smooth muscle cells (SMC) , skin and foreskin fibroblasts . Positive_regulation TNF AKT1 11247802 793333 The *activation* of phosphatidylinositol (PI) 3-kinase and kinase B (PKB) by [tumor necrosis factor (TNF)-alpha] and their roles on stimulation of protein synthesis were investigated in cultured neonatal rat cardiac myocytes . Positive_regulation TNF AKT1 11247802 793343 [TNF-alpha] *induced* marked activation of PI3-kinase and , and the activation of PI3-kinase and Akt/PKB was rapid ( maximal at 10 and 15 min , respectively ) and concentration dependent . Positive_regulation TNF AKT1 11287630 800304 Conversely , [TNF] inhibition of IRS-1 tyrosine phosphorylation was *blocked* by kinase dead . Positive_regulation TNF AKT1 11356844 834401 *Activation* of phosphatidylinositol (PI) <3-kinase/Akt> signaling by [tumor necrosis factor (TNF)] activates IKK and NF-kappaB . Positive_regulation TNF AKT1 11356844 834442 The present study shows that PTEN , a tumor suppressor that inhibits PI 3-kinase function , impairs [TNF] *activation* of and the IKK complex in 293 cells . Positive_regulation TNF AKT1 12034358 948244 In SAS cells , [TNF] *induced* the phosphorylation of at both Ser473 and Thr308 , causing the activation of Akt , and also induced the phosphorylation and degradation of IkappaB ( inhibitor of NFkappaB ) . Positive_regulation TNF AKT1 12060576 952771 Strikingly , the *activation* of p42 ( mapk/erk2 ) and by [TNF-alpha] was also inhibited in the presence of NaCl . Positive_regulation TNF AKT1 12089369 959714 [TNF-alpha] stimulation *increased* association of PAK1 with . Positive_regulation TNF AKT1 12145106 969693 To determine the *role* of in [TNF-alpha] release , cells were transiently transfected with a dominant negative form of Akt ( K179M ) . Positive_regulation TNF AKT1 12606779 1062951 Moreover , phosphatidylinositol <3-kinase/Akt> signal was *required* for excess [TNF-alpha] production in human macrophages derived from THP-1 cells . Positive_regulation TNF AKT1 14532277 1174885 Furthermore , [TNF-] but not VEGF induced *activation* of VEGFR2 , , and EC migration are blunted in EC genetically deficient with Etk . Positive_regulation TNF AKT1 15746249 1403158 Collectively , our results suggest that [TNF-alpha] *induces* the caspase dependent degradation of via the cleavage and ubiquitination of Akt , which results in its degradation through the 26S proteasome . Positive_regulation TNF AKT1 16269668 1502340 In human endothelial cells , we found that eNOS activation by [TNF-alpha] is time dependent and *requires* activation of , a known eNOS activator . Positive_regulation TNF AKT1 16291729 1526047 *Activation* of MAPK and by anti-HER2/neu [ScFv-TNF-alpha] inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation TNF AKT1 16870179 1593117 CpG ODN induced the phosphorylation of Akt , and the inhibition of by LY294002 *suppressed* CpG ODN induced [TNF-alpha] , TNFR-II , and MMP-9 expressions . Positive_regulation TNF AKT1 16981137 1617027 [TNF-alpha] *induced* the phosphorylation of depending upon time . Positive_regulation TNF AKT1 17158602 1701112 In human tracheal smooth muscle cells , [TNF-alpha] *induced* MMP-9 expression and phosphorylation in a time dependent manner , which was attenuated by the inhibitors of Src ( PP1 ) , epidermal growth factor receptor ( AG1478 ) , PDGFR ( AG1296 ) , and PI3K ( LY294002 ) , respectively , revealed by reporter gene assay , RT-PCR , zymographic , and Western blot analyses . Positive_regulation TNF AKT1 17473139 1738298 Similarly , the inhibitor *reduced* [TNF-alpha] production by 83 % in response to titanium particles with adherent endotoxin without increasing cytotoxicity . Positive_regulation TNF AKT1 17994109 1851134 [TNF-alpha] triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 MAPK , ERK 1/2 , SAPK/JNK and activation , while increasing proliferation and migration . Positive_regulation TNF AKT1 18027881 1894630 Further evidence to support the inhibitory role of GSK-3beta in TNF-alpha expression is that ( Akt ) signaling , an upstream inhibitor of GSK-3beta , *promotes* [TNF-alpha] expression in LPS stimulated cardiomyocytes and this action of Akt signaling can be mimicked by GSK-3beta inactivation . Positive_regulation TNF AKT1 18207479 1876663 [TNFalpha] signaling *involves* PI-3-kinase <(PI3K)/protein kinase B (PKB)> , and p44/42 MAP kinase (MAPK) which are important in NF-kappaB activation . Positive_regulation TNF AKT1 18227124 1895555 Moreover , [TNF-alpha] *induced* and CaM kinase II phosphorylation via cascades through Src/EGFR/PI3K and PLC/calcium/CaM , respectively . Positive_regulation TNF AKT1 18701653 1974114 We used TNF treated C2C12 myotubes to test the hypothesis that signaling *mediates* [TNF] regulation of atrogin mRNA . Positive_regulation TNF AKT1 19836430 2196463 [TNFalpha] *induced* oxidative stress dependent signaling affects actin cytoskeletal organization in glioma cells . Positive_regulation TNF AKT1 20207017 2237085 Neutrophil infiltration , ICAM , [TNF-alpha] and iNOS mRNA expression , neuronal apoptosis and the expression of p-JNK , pSTAT1 and p-Erk were reduced and *increased* on C5aR inhibition in MRL/lpr brains . Positive_regulation TNF AKT1 20333651 2266147 We also showed that [TNF-alpha] *induced* translocation and the formation of an Akt/p65/p300 complex . Positive_regulation TNF AKT1 21545687 2554357 [Tumour necrosis factor-a (TNF-a)] significantly *induced* phosphorylation of p38 MAPK , ERK , and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation TNF AKT1 21836068 2495784 Inhibition of phosphatidylinositol-3 *blocked* the effects of TMD23 on chemotactic motility , matrix metalloproteinase-9 , interleukin-8 , and [TNF-a] . Positive_regulation TNF AKT1 21856755 2473274 In addition , [TNF-a] *induced* phosphorylation of extracellular signal regulated kinase , nuclear factor kappa B ( NF-?B ) and in a time dependent manner , and increased nuclear translocation and promoter activity of NF-?B . Positive_regulation TNF AKT1 21949832 2488053 Present study investigates the *role* of and Jak/Stat pathway in the IL-10 modulation of [TNF-a] induced cardiomyocyte apoptosis . Positive_regulation TNF AKT1 21949832 2488060 It is suggested that IL-10 modulation of [TNF-a] induced cardiomyocyte apoptosis is *mediated* by via Stat3 activation . Positive_regulation TNF AKT1 23108309 2691116 AR was necessary for [TNF-a] *activation* of ERK1/2 and signaling in hepatocytes . Positive_regulation TNF AKT1 23151904 2723050 When combined with TNF-a , it suppresses [TNF-a] *activation* of by inhibiting TNF-a induced tRXR-a interaction with the p85a regulatory subunit of PI3K . Positive_regulation TNF AKT1 23151904 2723057 CF31 inhibition of [TNF-a] *activation* of also results in TNF-a dependent activation of caspase-8 and apoptosis . Positive_regulation TNF AKT1 23188524 2745402 We found that MAPK and inhibitors , but not PI3K inhibitor , remarkably *suppressed* ACPA mediated [TNF-a] production . Positive_regulation TNF AKT1 23243069 2757873 The inhibition of iTreg differentiation by TNF-a is mediated through a signaling cascade involving the induction of [TNF receptor II (TNFR2)] expression and the *activation* of . Positive_regulation TNF AKT1 23427281 2887207 The [TNF-a] *induces* eNOS and MMP-9 expression and activation . Positive_regulation TNF AKT1 24151609 2859732 [TNF] a mediated IL-6 secretion is *regulated* by JAK/STAT pathway but not by MEK phosphorylation and phosphorylation in U266 multiple myeloma cells . Positive_regulation TNF AKT1 24165986 2910154 Inhibition of activity markedly *attenuated* the expression of IFN-? and [TNF-a] in thymic Tgfbr2?/? Treg cells in vivo . Positive_regulation TNF AKT1 24441870 2922962 On the other hand , [TNF-a] could *induce* and p42/p44 MAPK translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation TNF AKT2 10485710 644527 Thus , both and NIK are *necessary* for [TNF] activation of NF-kappaB . Positive_regulation TNF AKT2 10974038 729198 in turn can *regulate* positively the transcriptional activity of interleukin (IL)-2 and [tumor necrosis factor (TNF)-alpha] promoters . Positive_regulation TNF AKT2 10974038 729210 Importantly , *regulates* the production and secretion of IL-2 and [TNF-alpha] in FcepsilonRI stimulated mast cells . Positive_regulation TNF AKT2 10984605 732216 The present study investigates the *role* of in the activation of NF-kappa B by [tumor necrosis factor-alpha] ( TNF alpha , 10 ng/ml ) and PDGF-BB ( 20 ng/ml ) in human vascular smooth muscle cells (SMC) , skin and foreskin fibroblasts . Positive_regulation TNF AKT2 11247802 793334 The *activation* of phosphatidylinositol (PI) 3-kinase and kinase B (PKB) by [tumor necrosis factor (TNF)-alpha] and their roles on stimulation of protein synthesis were investigated in cultured neonatal rat cardiac myocytes . Positive_regulation TNF AKT2 11247802 793344 [TNF-alpha] *induced* marked activation of PI3-kinase and , and the activation of PI3-kinase and Akt/PKB was rapid ( maximal at 10 and 15 min , respectively ) and concentration dependent . Positive_regulation TNF AKT2 11287630 800305 Conversely , [TNF] inhibition of IRS-1 tyrosine phosphorylation was *blocked* by kinase dead . Positive_regulation TNF AKT2 11356844 834402 *Activation* of phosphatidylinositol (PI) <3-kinase/Akt> signaling by [tumor necrosis factor (TNF)] activates IKK and NF-kappaB . Positive_regulation TNF AKT2 11356844 834443 The present study shows that PTEN , a tumor suppressor that inhibits PI 3-kinase function , impairs [TNF] *activation* of and the IKK complex in 293 cells . Positive_regulation TNF AKT2 12034358 948245 In SAS cells , [TNF] *induced* the phosphorylation of at both Ser473 and Thr308 , causing the activation of Akt , and also induced the phosphorylation and degradation of IkappaB ( inhibitor of NFkappaB ) . Positive_regulation TNF AKT2 12060576 952772 Strikingly , the *activation* of p42 ( mapk/erk2 ) and by [TNF-alpha] was also inhibited in the presence of NaCl . Positive_regulation TNF AKT2 12089369 959715 [TNF-alpha] stimulation *increased* association of PAK1 with . Positive_regulation TNF AKT2 12145106 969694 To determine the *role* of in [TNF-alpha] release , cells were transiently transfected with a dominant negative form of Akt ( K179M ) . Positive_regulation TNF AKT2 12606779 1062952 Moreover , phosphatidylinositol <3-kinase/Akt> signal was *required* for excess [TNF-alpha] production in human macrophages derived from THP-1 cells . Positive_regulation TNF AKT2 14532277 1174886 Furthermore , [TNF-] but not VEGF induced *activation* of VEGFR2 , , and EC migration are blunted in EC genetically deficient with Etk . Positive_regulation TNF AKT2 15746249 1403159 Collectively , our results suggest that [TNF-alpha] *induces* the caspase dependent degradation of via the cleavage and ubiquitination of Akt , which results in its degradation through the 26S proteasome . Positive_regulation TNF AKT2 16269668 1502341 In human endothelial cells , we found that eNOS activation by [TNF-alpha] is time dependent and *requires* activation of , a known eNOS activator . Positive_regulation TNF AKT2 16291729 1526048 *Activation* of MAPK and by anti-HER2/neu [ScFv-TNF-alpha] inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation TNF AKT2 16870179 1593118 CpG ODN induced the phosphorylation of Akt , and the inhibition of by LY294002 *suppressed* CpG ODN induced [TNF-alpha] , TNFR-II , and MMP-9 expressions . Positive_regulation TNF AKT2 16981137 1617028 [TNF-alpha] *induced* the phosphorylation of depending upon time . Positive_regulation TNF AKT2 17158602 1701113 In human tracheal smooth muscle cells , [TNF-alpha] *induced* MMP-9 expression and phosphorylation in a time dependent manner , which was attenuated by the inhibitors of Src ( PP1 ) , epidermal growth factor receptor ( AG1478 ) , PDGFR ( AG1296 ) , and PI3K ( LY294002 ) , respectively , revealed by reporter gene assay , RT-PCR , zymographic , and Western blot analyses . Positive_regulation TNF AKT2 17473139 1738299 Similarly , the inhibitor *reduced* [TNF-alpha] production by 83 % in response to titanium particles with adherent endotoxin without increasing cytotoxicity . Positive_regulation TNF AKT2 17994109 1851135 [TNF-alpha] triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 MAPK , ERK 1/2 , SAPK/JNK and activation , while increasing proliferation and migration . Positive_regulation TNF AKT2 18227124 1895556 Moreover , [TNF-alpha] *induced* and CaM kinase II phosphorylation via cascades through Src/EGFR/PI3K and PLC/calcium/CaM , respectively . Positive_regulation TNF AKT2 18701653 1974115 We used TNF treated C2C12 myotubes to test the hypothesis that signaling *mediates* [TNF] regulation of atrogin mRNA . Positive_regulation TNF AKT2 19836430 2196464 [TNFalpha] *induced* oxidative stress dependent signaling affects actin cytoskeletal organization in glioma cells . Positive_regulation TNF AKT2 20207017 2237086 Neutrophil infiltration , ICAM , [TNF-alpha] and iNOS mRNA expression , neuronal apoptosis and the expression of p-JNK , pSTAT1 and p-Erk were reduced and *increased* on C5aR inhibition in MRL/lpr brains . Positive_regulation TNF AKT2 20333651 2266148 We also showed that [TNF-alpha] *induced* Akt translocation and the formation of an complex . Positive_regulation TNF AKT2 21545687 2554358 [Tumour necrosis factor-a (TNF-a)] significantly *induced* phosphorylation of p38 MAPK , ERK , and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation TNF AKT2 21836068 2495785 Inhibition of phosphatidylinositol-3 *blocked* the effects of TMD23 on chemotactic motility , matrix metalloproteinase-9 , interleukin-8 , and [TNF-a] . Positive_regulation TNF AKT2 21856755 2473275 In addition , [TNF-a] *induced* phosphorylation of extracellular signal regulated kinase , nuclear factor kappa B ( NF-?B ) and in a time dependent manner , and increased nuclear translocation and promoter activity of NF-?B . Positive_regulation TNF AKT2 21949832 2488054 Present study investigates the *role* of and Jak/Stat pathway in the IL-10 modulation of [TNF-a] induced cardiomyocyte apoptosis . Positive_regulation TNF AKT2 21949832 2488061 It is suggested that IL-10 modulation of [TNF-a] induced cardiomyocyte apoptosis is *mediated* by via Stat3 activation . Positive_regulation TNF AKT2 23108309 2691117 AR was necessary for [TNF-a] *activation* of ERK1/2 and signaling in hepatocytes . Positive_regulation TNF AKT2 23151904 2723051 When combined with TNF-a , it suppresses [TNF-a] *activation* of by inhibiting TNF-a induced tRXR-a interaction with the p85a regulatory subunit of PI3K . Positive_regulation TNF AKT2 23151904 2723058 CF31 inhibition of [TNF-a] *activation* of also results in TNF-a dependent activation of caspase-8 and apoptosis . Positive_regulation TNF AKT2 23188524 2745403 We found that MAPK and inhibitors , but not PI3K inhibitor , remarkably *suppressed* ACPA mediated [TNF-a] production . Positive_regulation TNF AKT2 23243069 2757874 The inhibition of iTreg differentiation by TNF-a is mediated through a signaling cascade involving the induction of [TNF receptor II (TNFR2)] expression and the *activation* of . Positive_regulation TNF AKT2 24151609 2859733 [TNF] a mediated IL-6 secretion is *regulated* by JAK/STAT pathway but not by MEK phosphorylation and phosphorylation in U266 multiple myeloma cells . Positive_regulation TNF AKT2 24165986 2910155 Inhibition of activity markedly *attenuated* the expression of IFN-? and [TNF-a] in thymic Tgfbr2?/? Treg cells in vivo . Positive_regulation TNF AKT2 24441870 2922963 On the other hand , [TNF-a] could *induce* and p42/p44 MAPK translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation TNF AKT3 10485710 644528 Thus , both and NIK are *necessary* for [TNF] activation of NF-kappaB . Positive_regulation TNF AKT3 10974038 729199 in turn can *regulate* positively the transcriptional activity of interleukin (IL)-2 and [tumor necrosis factor (TNF)-alpha] promoters . Positive_regulation TNF AKT3 10974038 729211 Importantly , *regulates* the production and secretion of IL-2 and [TNF-alpha] in FcepsilonRI stimulated mast cells . Positive_regulation TNF AKT3 10984605 732217 The present study investigates the *role* of in the activation of NF-kappa B by [tumor necrosis factor-alpha] ( TNF alpha , 10 ng/ml ) and PDGF-BB ( 20 ng/ml ) in human vascular smooth muscle cells (SMC) , skin and foreskin fibroblasts . Positive_regulation TNF AKT3 11247802 793335 The *activation* of phosphatidylinositol (PI) 3-kinase and kinase B (PKB) by [tumor necrosis factor (TNF)-alpha] and their roles on stimulation of protein synthesis were investigated in cultured neonatal rat cardiac myocytes . Positive_regulation TNF AKT3 11247802 793345 [TNF-alpha] *induced* marked activation of PI3-kinase and , and the activation of PI3-kinase and Akt/PKB was rapid ( maximal at 10 and 15 min , respectively ) and concentration dependent . Positive_regulation TNF AKT3 11287630 800306 Conversely , [TNF] inhibition of IRS-1 tyrosine phosphorylation was *blocked* by kinase dead . Positive_regulation TNF AKT3 11356844 834403 *Activation* of phosphatidylinositol (PI) <3-kinase/Akt> signaling by [tumor necrosis factor (TNF)] activates IKK and NF-kappaB . Positive_regulation TNF AKT3 11356844 834444 The present study shows that PTEN , a tumor suppressor that inhibits PI 3-kinase function , impairs [TNF] *activation* of and the IKK complex in 293 cells . Positive_regulation TNF AKT3 12034358 948246 In SAS cells , [TNF] *induced* the phosphorylation of at both Ser473 and Thr308 , causing the activation of Akt , and also induced the phosphorylation and degradation of IkappaB ( inhibitor of NFkappaB ) . Positive_regulation TNF AKT3 12060576 952773 Strikingly , the *activation* of p42 ( mapk/erk2 ) and by [TNF-alpha] was also inhibited in the presence of NaCl . Positive_regulation TNF AKT3 12089369 959716 [TNF-alpha] stimulation *increased* association of PAK1 with . Positive_regulation TNF AKT3 12145106 969695 To determine the *role* of in [TNF-alpha] release , cells were transiently transfected with a dominant negative form of Akt ( K179M ) . Positive_regulation TNF AKT3 12606779 1062953 Moreover , phosphatidylinositol <3-kinase/Akt> signal was *required* for excess [TNF-alpha] production in human macrophages derived from THP-1 cells . Positive_regulation TNF AKT3 14532277 1174887 Furthermore , [TNF-] but not VEGF induced *activation* of VEGFR2 , , and EC migration are blunted in EC genetically deficient with Etk . Positive_regulation TNF AKT3 15746249 1403160 Collectively , our results suggest that [TNF-alpha] *induces* the caspase dependent degradation of via the cleavage and ubiquitination of Akt , which results in its degradation through the 26S proteasome . Positive_regulation TNF AKT3 16269668 1502342 In human endothelial cells , we found that eNOS activation by [TNF-alpha] is time dependent and *requires* activation of , a known eNOS activator . Positive_regulation TNF AKT3 16291729 1526049 *Activation* of MAPK and by anti-HER2/neu [ScFv-TNF-alpha] inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation TNF AKT3 16870179 1593119 CpG ODN induced the phosphorylation of Akt , and the inhibition of by LY294002 *suppressed* CpG ODN induced [TNF-alpha] , TNFR-II , and MMP-9 expressions . Positive_regulation TNF AKT3 16981137 1617029 [TNF-alpha] *induced* the phosphorylation of depending upon time . Positive_regulation TNF AKT3 17158602 1701114 In human tracheal smooth muscle cells , [TNF-alpha] *induced* MMP-9 expression and phosphorylation in a time dependent manner , which was attenuated by the inhibitors of Src ( PP1 ) , epidermal growth factor receptor ( AG1478 ) , PDGFR ( AG1296 ) , and PI3K ( LY294002 ) , respectively , revealed by reporter gene assay , RT-PCR , zymographic , and Western blot analyses . Positive_regulation TNF AKT3 17473139 1738300 Similarly , the inhibitor *reduced* [TNF-alpha] production by 83 % in response to titanium particles with adherent endotoxin without increasing cytotoxicity . Positive_regulation TNF AKT3 17994109 1851136 [TNF-alpha] triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 MAPK , ERK 1/2 , SAPK/JNK and activation , while increasing proliferation and migration . Positive_regulation TNF AKT3 18227124 1895557 Moreover , [TNF-alpha] *induced* and CaM kinase II phosphorylation via cascades through Src/EGFR/PI3K and PLC/calcium/CaM , respectively . Positive_regulation TNF AKT3 18701653 1974116 We used TNF treated C2C12 myotubes to test the hypothesis that signaling *mediates* [TNF] regulation of atrogin mRNA . Positive_regulation TNF AKT3 19836430 2196465 [TNFalpha] *induced* oxidative stress dependent signaling affects actin cytoskeletal organization in glioma cells . Positive_regulation TNF AKT3 20207017 2237087 Neutrophil infiltration , ICAM , [TNF-alpha] and iNOS mRNA expression , neuronal apoptosis and the expression of p-JNK , pSTAT1 and p-Erk were reduced and *increased* on C5aR inhibition in MRL/lpr brains . Positive_regulation TNF AKT3 20333651 2266149 We also showed that [TNF-alpha] *induced* translocation and the formation of an Akt/p65/p300 complex . Positive_regulation TNF AKT3 21545687 2554359 [Tumour necrosis factor-a (TNF-a)] significantly *induced* phosphorylation of p38 MAPK , ERK , and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation TNF AKT3 21836068 2495786 Inhibition of phosphatidylinositol-3 *blocked* the effects of TMD23 on chemotactic motility , matrix metalloproteinase-9 , interleukin-8 , and [TNF-a] . Positive_regulation TNF AKT3 21856755 2473276 In addition , [TNF-a] *induced* phosphorylation of extracellular signal regulated kinase , nuclear factor kappa B ( NF-?B ) and in a time dependent manner , and increased nuclear translocation and promoter activity of NF-?B . Positive_regulation TNF AKT3 21949832 2488055 Present study investigates the *role* of and Jak/Stat pathway in the IL-10 modulation of [TNF-a] induced cardiomyocyte apoptosis . Positive_regulation TNF AKT3 21949832 2488062 It is suggested that IL-10 modulation of [TNF-a] induced cardiomyocyte apoptosis is *mediated* by via Stat3 activation . Positive_regulation TNF AKT3 23108309 2691118 AR was necessary for [TNF-a] *activation* of ERK1/2 and signaling in hepatocytes . Positive_regulation TNF AKT3 23151904 2723052 When combined with TNF-a , it suppresses [TNF-a] *activation* of by inhibiting TNF-a induced tRXR-a interaction with the p85a regulatory subunit of PI3K . Positive_regulation TNF AKT3 23151904 2723059 CF31 inhibition of [TNF-a] *activation* of also results in TNF-a dependent activation of caspase-8 and apoptosis . Positive_regulation TNF AKT3 23188524 2745404 We found that MAPK and inhibitors , but not PI3K inhibitor , remarkably *suppressed* ACPA mediated [TNF-a] production . Positive_regulation TNF AKT3 23243069 2757875 The inhibition of iTreg differentiation by TNF-a is mediated through a signaling cascade involving the induction of [TNF receptor II (TNFR2)] expression and the *activation* of . Positive_regulation TNF AKT3 24151609 2859734 [TNF] a mediated IL-6 secretion is *regulated* by JAK/STAT pathway but not by MEK phosphorylation and phosphorylation in U266 multiple myeloma cells . Positive_regulation TNF AKT3 24165986 2910156 Inhibition of activity markedly *attenuated* the expression of IFN-? and [TNF-a] in thymic Tgfbr2?/? Treg cells in vivo . Positive_regulation TNF AKT3 24441870 2922964 On the other hand , [TNF-a] could *induce* and p42/p44 MAPK translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation TNF ALB 12504894 1034107 Methylglyoxal-bovine *stimulates* [tumor necrosis factor] alpha secretion in RAW 264.7 cells through activation of mitogen activating protein kinase , nuclear factor kappaB and intracellular reactive oxygen species formation . Positive_regulation TNF ALB 12504894 1034110 Our findings suggest that the presence of chronically elevated levels of MGO modified bovine may *contribute* to elevated levels of [TNFalpha] in diabetes . Positive_regulation TNF ALB 14991464 1215465 We show that chicken egg prepared with glucose and chicken egg albumin-AGEs prepared with methylglyoxal dose-dependently *induce* [TNF-alpha] release . Positive_regulation TNF ALB 15749029 1379481 Negligible *induction* of IFN-gamma , IL-12 and [TNF-alpha] by DNA-PEI 750 complexes . Positive_regulation TNF ALB 21514428 2418734 The results showed that activation of A ( 2A ) AR attenuated Amadori glycated *induced* [TNF-a] release in a cAMP/exchange protein directly activated by cAMP dependent mechanism and significantly repressed the inflammatory cascade , C-Raf/extracellular signal regulated kinase ( ERK ) , in activated microglia . Positive_regulation TNF ALB 2313095 130119 The expression of maleyl *stimulated* [TNF-alpha] mRNA expression could be reproduced by lipid extracts of oxidized LDL provided to macrophages at the same cholesterol concentration as from the intact lipoprotein particle . Positive_regulation TNF ALB 7718622 301351 The binding of short-term glycated to MonoMac 6 cells *induced* the production of the cytokines IL-1 and [TNF] . Positive_regulation TNF ALB 8995714 409633 Glycated *induced* increased mRNA expression and synthesis of [TNF-alpha] . Positive_regulation TNF ALB 9293394 452855 Human minimally modified by methylglyoxal ( MGmin-HSA ) *stimulated* the synthesis and secretion of [tumour necrosis factor-alpha (TNF-alpha)] from human monocytic THP-1 cells in vitro . Positive_regulation TNF ALB 9293394 452856 Human minimally modified by glucose derived advanced glycation endproducts ( AGEmin-HSA ) and human serum albumin highly modified by glucose derived advanced glycation endproducts ( AGE-HSA ) *stimulated* markedly lower synthesis and secretion of [TNF-alpha] from THP-1 cells than did MGmin-HSA . Positive_regulation TNF ALOX5 11090070 754416 Granulocyte-macrophage colony stimulating factor ( GM-CSF ) plus [tumor necrosis factor-alpha (TNF-alpha)] promoted DC differentiation and *induced* a strong rise in <5-LO> and FLAP expression . Positive_regulation TNF ALOX5 11390371 842558 We show that in addition to inhibitors of secretory and cytosolic PLA(2)s , <5-lipoxygenase> inhibitors *attenuate* [TNF-alpha-] and IL-1beta stimulated NF-kappaB activation . Positive_regulation TNF ALOX5 11735348 885763 Moreover , inhibition of <5-lipoxygenase> indirectly *reduces* the expression of [TNF-alpha] ( a cytokine that plays a key role in inflammation ) . Positive_regulation TNF ALOX5 12733982 1030635 moreover , inhibition of <5-lipoxygenase> indirectly *reduces* the expression of [TNF-alpha] ( a cytokine that plays a key role in inflammation ) . Positive_regulation TNF ALOX5 1650523 163016 In vitro studies have demonstrated that <5-lipoxygenase> products *promote* the production of [TNF] by activated macrophages , suggesting that 5-lipoxygenase inhibitors may have therapeutic utility for the treatment of inflammatory conditions . Positive_regulation TNF ALOX5 1783470 175975 Since <5-lipoxygenase> inhibitors neither *prevented* the formation of [TNF alpha] nor endotoxin leukopenia and lethality , it is suggested that a lipoxygenase product distinct from the leukotrienes is involved in TNF alpha synthesis . Positive_regulation TNF ALOX5 1906437 161731 Finally , the <5-lipoxygenase> inhibitors , ketoconazole and L-656,224 , but not the cyclo-oxygenase inhibitor ASA , *inhibited* [TNF] stimulated by all agents . Positive_regulation TNF ALOX5 19938896 2190512 Further , we found that the <5-LO> inhibitor nordihydrogualaretic acid ( NDGA ) significantly *reduced* both MEHP induced [TNF-alpha] release and MEHP induced formation of reactive oxygen species ( ROS ) , supporting an involvement of the 5-LO pathway in MEHP induced inflammatory reactions . Positive_regulation TNF ALOX5 2494431 108023 Although indomethacin had no detectable effect on this induction of TNF transcripts , ketoconazole , an inhibitor of <5-lipoxygenase> , *blocked* TPA induced increases in [TNF] mRNA levels . Positive_regulation TNF ALOX5 2545780 114314 Inhibition of <5-lipoxygenase> by nordihydro-guaiaretic acid or AA-861 *blocked* the PAF induced augmentation of both [TNF] and LTB4 production . Positive_regulation TNF ALOX5 8273590 239505 As previously reported , the <5-lipoxygenase/cyclooxygenase (5-LO/CO)> inhibitor , SKF86002 ( 30 microM ) , significantly *inhibited* both IL-1 beta and [TNF-alpha] release using either stimulus . Positive_regulation TNF ALOX5 8564522 342161 In LPS stimulated blood , SKF-86002 , a <5-lipoxygenase/cytooxygenasae> inhibitor , and rolipram , a PDE IV inhibitor , also *inhibited* the release of [TNF alpha] ( IC50s of 33 and 11 microM , respectively ) , IL-1 beta ( IC50s of 11 and 30 microM , respectively ) , IL-6 ( IC50s of 56 and > 30 , respectively ) and IL-8 ( IC50s of 6.7 and 15 , respectively ) , whereas isoproterenol ( 1 microM ) inhibited significantly only TNF alpha release . Positive_regulation TNF ALOX5AP 11090070 754417 Granulocyte-macrophage colony stimulating factor ( GM-CSF ) plus [tumor necrosis factor-alpha (TNF-alpha)] promoted DC differentiation and *induced* a strong rise in 5-LO and expression . Positive_regulation TNF ALPI 23306083 2752589 To study the anti-inflammatory effect of IAP , UDP or other proinflammatory ligands ( LPS , flagellin , Pam3Cys , or [TNF-a] ) in the *presence* or absence of were applied to cell cultures , and IL-8 was measured . Positive_regulation TNF ANG 10999742 734342 In an in vitro study , interleukin-1beta and [tumor necrosis factor-alpha] *induced* mRNA expression in colon cancer cells in a dose- and time dependent manner , and these cytokines significantly upregulated the expression of angiogenin mRNA , especially in colon cancer cells rather than in other cells in the stroma of tumor tissues ( fibroblasts , tumor infiltrating lymphocytes , macrophages ) . Positive_regulation TNF ANG 11928713 927210 The present study was designed to clarify the *role* of in modulating renal [tumor necrosis factor (TNF)-alpha] and interleukin-6 (IL-6) production and to investigate the effect of one dose of Ang II inhibitor on cytokines production following lipopolysaccharide (LPS) to cause endotoxemia . Positive_regulation TNF ANG 11994255 938872 Previous studies suggest that *upregulates* the expression of [tumor necrosis factor (TNF)] in nonmyocyte cell types ; Positive_regulation TNF ANG 12802423 1101304 isolated from cow milk *induces* the production of cytokines IL-1beta , IL-6 , and [TNF-alpha] in human leukocytes ; Positive_regulation TNF ANG 14519430 1147712 We recently showed that II as well as mechanical stretch *stimulated* production of [tumor necrosis factor (TNF)] in cardiac fibroblasts . Positive_regulation TNF ANG 14965324 1208872 Our initial studies on renal cyclooxygenase (COX)-2 expression and activity addressed the critical *role* of in increasing [tumor necrosis factor alpha (TNF)] that eventuated in expression of COX-2 in the medullary thick ascending limb ( mTAL ) of the nephron . Positive_regulation TNF ANGPT2 10362677 620125 ( > /=10 ( -8 ) M ) and mechanical stretch *stimulated* the production of [TNF] in cardiac fibroblasts but not in myocytes . Positive_regulation TNF ANGPT2 12200113 982723 However , following the addition of indomethacin or H-89 , significantly *increased* [TNF-alpha] release , transcriptional activity , and mRNA level . Positive_regulation TNF ANGPT2 12480812 1024242 [Tumor necrosis factor-alpha (TNF-alpha)] and levels *increase* after MI and both factors affect fibroblast functions . Positive_regulation TNF ANGPT2 12512690 1027680 This switching mechanism ( CYP > COX-2 ) has been shown to be dependent on *activation* of [tumor necrosis factor alpha (TNFalpha)] by . Positive_regulation TNF ANGPT2 12763281 1093883 did not significantly *trigger* [TNF-alpha] secretion in both groups . Positive_regulation TNF ANGPT2 14644777 1210227 *increased* TNF-alpha mRNA and protein expression and the release of bioactive [TNF-alpha] . Positive_regulation TNF ANGPT2 14644777 1210232 To elucidate whether endogenous [TNF-alpha] could *mediate* the effects of on MMP-2 release , cells were pretreated with anti-TNF-alpha neutralizing antibodies or pentoxifylline ( an inhibitor of TNF-alpha synthesis ) . Positive_regulation TNF ANGPT2 16837769 1587710 Alacepril , CV-11974 , and spironolactone significantly reduced the enhanced production of MCP-1 and [TNF-alpha] *induced* by exogenous . Positive_regulation TNF ANGPT2 17595330 1786380 ( 1 nM intraperitoneally in rats ) *induced* [TNFalpha] release at 1 hour followed by neutrophil and mononuclear cell recruitment . Positive_regulation TNF ANGPT2 17595330 1786381 Stimulation of human umbilical arterial endothelial cells ( HUAECs ) or isolated human mononuclear cells with 1 microM *caused* increased [TNFalpha] mRNA expression and protein . Positive_regulation TNF ANGPT2 18060435 1853611 Exogenous significantly *increased* TF activity and TF mRNA in [TNF-alpha-] +/- Stx-1 activated HGECs . Positive_regulation TNF ANGPT2 18073321 1861961 Moreover , treatment of L6 myotubes *induced* NF-kappaB activation and [TNF-alpha] production and decreased insulin stimulated Akt activation and GLUT-4 glucose transporter translocation to plasma membranes . Positive_regulation TNF ANGPT2 19073907 2024163 AT1 receptors were primarily expressed intracellularly , and endogenously produced *increased* T-cell activation , expression of tissue homing markers , and production of the cytokine [TNF-alpha] . Positive_regulation TNF ANGPT2 19471094 2085357 and LPS *stimulated* [TNF-alpha] secretion and inhibited 6-keto-PGF ( 1alpha ) production , upregulated MMP-9 and downregulated PPARgamma and PPARalphain rat VSMCs . Positive_regulation TNF ANGPT2 19628784 2137863 c-Fms expression in HSCs/promonocytes was mainly regulated by TNF-alpha derived from BM CD45 ( - ) CD34 ( - ) stromal cells , and specifically *regulated* the [TNF-alpha] synthesis and release from BM stromal cells . Positive_regulation TNF ANGPT2 21235392 2402678 not only *induced* the production of [tumor necrosis factor-a] , IL-1ß , IL-6 , and IL-10 but also increased the release of ROS . Positive_regulation TNF ANGPT2 22223068 2569090 , after at least 72 h of repeated treatment , *increased* basal [TNFA] gene expression and cytokine release with a biphasic pattern and maximum response at 10 nM . Positive_regulation TNF ANGPT2 22223068 2569092 Moreover , *causes* [tumor necrosis factor receptor (TNFR)] 1 and TNFR2 over-expression in a time dependent manner . Positive_regulation TNF ANGPT2 23337087 2747265 In this study , we demonstrate that in vitro , using a human monocyte-to-fibroblast differentiation model , *required* the presence of [tumor necrosis factor-alpha (TNF)] to induce fibroblast maturation from monocytes . Positive_regulation TNF ANGPT2 24049058 2867002 augmented the WRS lesions , decreased GBF and *increased* the plasma IL-1ß and [TNF-a] levels . Positive_regulation TNF ANGPTL2 21501655 2439098 [Tumor necrosis factor-a] *increases* gene expression by activating Foxo1 in 3T3-L1 adipocytes . Positive_regulation TNF ANPEP 12184631 978132 Up-regulation of N induced by phorbol ester is *involved* in redox regulation and [tumor necrosis factor] alpha production in HL-60 cells . Positive_regulation TNF ANPEP 19910632 2189371 These data show that TZDs attenuate pathological retinal microvessel formation through *mediated* modulation of [TNF-alpha] production . Positive_regulation TNF ANXA1 18684973 1949186 [TNF-alpha] *induced* a biphasic secretion of from RA SF . Positive_regulation TNF ANXA1 19553536 2104074 *regulates* macrophage IL-6 and [TNF] via glucocorticoid induced leucine zipper . Positive_regulation TNF ANXA1 22164217 2517877 The results show that can negatively *regulate* phosphorylation of p38 and release of IL-1ß , IL-6 and [TNF-a] in THP-1 cells following propofol intervention and lipopolysaccharide (LPS) stimulation . Positive_regulation TNF ANXA5 18180277 1943942 Apoptosis of PBMCs was studied by stimulation with [TNFalpha] in the *presence* of cycloheximide and staining . Positive_regulation TNF ANXA6 12871593 1114121 Interestingly , we have found that IL-12 , p402 ( the p40 homodimer ) and p40 ( the p40 monomer ) dose-dependently *induced* the production of [TNF-alpha] and the expression of TNF-alpha mRNA in BV-2 microglial cells . Positive_regulation TNF ANXA6 12871593 1114126 In addition to BV-2 microglial cells , , p402 and p40 also *induced* the production of [TNF-alpha] in mouse primary microglia and peritoneal macrophages . Positive_regulation TNF ANXA6 15683451 1370611 Polyriboinosinic polyribocytidylic acid ( Poly I:C ) + [tumour necrosis factor-alpha (TNF-alpha)] *induced* significant IL-12 secretion , which was increased after addition of a decoy IL-10 receptor . Positive_regulation TNF APC 9053444 417223 A activated by LPS *had* the same inhibitory effects on IFN-gamma and [TNF-alpha] production by B10 .BR TCL . Positive_regulation TNF APCS 15778396 1385094 Our results demonstrate that in the *presence* of , beryllium induced strong proliferation responses of BAL CD4 ( + ) T cells , production of superoptimal concentrations of secreted proinflammatory cytokines , IFN-gamma , [TNF-alpha] , and IL-2 , and up-regulation of numerous T cell surface markers that would promote T-T Ag presentation . Positive_regulation TNF APCS 18795974 2053058 In response to TGF-beta , *increase* their expression of [tumour necrosis factor (TNF)-alpha] and TNF receptor 2 (TNF-R2) . Positive_regulation TNF APOA1 21421044 2421612 Macrophage stimulation studies showed that oxidized *increased* [TNF-a] levels and augmented TNF-a release by lipopolysaccharide , effects that were prevented by MESNA . Positive_regulation TNF APOA1 21421044 2421613 This study is the first to demonstrate that DOX oxidizes plasma APOA1 , that oxidized *enhances* macrophage [TNF-a] release and thus could contribute to potential subsequent TNF-a mediated toxicity , and that MESNA interacts with DOX to block this mechanism and suggests that MESNA could reduce systemic side effects of DOX . Positive_regulation TNF APOA1 22271762 2586209 We have shown that endogenous *stabilizes* ABCA1 , moreover , down-regulation of ApoA-I by siRNA results in an increase of Toll-like receptor 4 (TLR4) mRNA and membrane surface protein expression , as well as an enhancement of bacterial lipopolysaccharide (LPS) induced expression of [tumor necrosis factor-a (TNF-a)] , interleukin 1ß (IL-1ß) , and inducible nitric oxide synthase ( NOS2 ) genes in human macrophages . Positive_regulation TNF APOB 10394297 627353 They show that with a panel of macrophage-like cell lines of varying maturation ( P388D , THP-1 , U937 , HL-60 ) , the ability to produce TNF alpha spontaneously and to synthesize [TNF alpha] in *response* to atherogenic low-density stimulation correlates with the degree of cell differentiation that can be in turn induced by agents such as phorbol myristic acetate . Positive_regulation TNF APOB 10412737 630859 Exposure to VLDL , IDL , LDL , or a high concentration of HDL enhanced the secretion of IL-6 , PDGF-AB , and TGF-beta by mesangial cells , whereas [TNF-alpha] secretion was *stimulated* by oxidized . Positive_regulation TNF APOB 10559223 566459 Importantly , a TLR2 antibody inhibited bacterial *induced* [tumor necrosis factor] release from human peripheral blood mononuclear cells , and TLR2-null Chinese hamster macrophages were insensitive to lipoprotein/lipopeptide challenge . Positive_regulation TNF APOB 10657578 664019 In contrast , the study suggests that very-low-density ( VLDL ) in hypertriglyceridemic patients *augments* [TNF-alpha] production . Positive_regulation TNF APOB 11031205 740166 The present findings support the notion that may *activate* arterial expression of [TNF-alpha] and suggest 1 possible mechanism for the inflammatory response in the early stages of atherosclerosis . Positive_regulation TNF APOB 11583711 865795 Oxidized , as well as a combination of cholesterol and 25-hydroxycholesterol , *induced* [tumor necrosis factor-alpha (TNFalpha)] and interleukin-1 beta (IL-1 beta) mRNA as measured by quantitative real time PCR , by a maximum of two- to fourfold following a 24-h incubation . Positive_regulation TNF APOB 11583711 865797 VK-19911 ( Pyridine , 4- [ 4- ( 4-fluorophenyl ) -1- ( 4-piperidinyl ) -1H-imidazol-5-yl ] -dihydrochloride ) , a specific inhibitor of p38 alpha , prevented the *induction* of [TNFalpha] and IL-1 beta by oxidized in a dose dependent manner . Positive_regulation TNF APOB 11890657 894237 LPS , the mycobacterial glycolipids , and the OspC ( a TLR2 agonist ) all *induced* macrophages to secrete [tumour necrosis factor alpha (TNFalpha)] , whereas only LPS could induce nitric oxide ( NO ) secretion . Positive_regulation TNF APOB 14612200 1162860 Here we have investigated whether the state of monocyte-macrophage differentiation can influence [TNF alpha] synthesis in *response* to scavenged modified . Positive_regulation TNF APOB 15021964 1221906 In MDM , intracellular [TNF alpha] and IL-12 expression was *induced* by mannan , native and modified , but not other ligands . Positive_regulation TNF APOB 15164729 1253167 In addition , *enhances* the production and release of [tumor necrosis factor] ( TNF-alpha ) , interleukin (IL)-6 , arachidonic acid metabolites and nitric oxide ( NO ) that are responsible for various human pathologies including cancer . Positive_regulation TNF APOB 15210062 1261858 In cultured ECV304 cells , or ox-LDL markedly *increased* the level of ADMA and [TNF-alpha] and potentiated the adhesion of monocytes to endothelial cells , concomitantly with a significantly decrease in the activity of DDAH and serum level of NO . Positive_regulation TNF APOB 15569408 1344000 Aspirin inhibited the increased level of MDA and [TNF-alpha] *induced* by . Positive_regulation TNF APOB 15893422 1419723 Lipoproteins are the key inflammatory molecule type of Borrelia burgdorferi , the spirochete that causes Lyme disease , and we had previously shown that *induced* [TNF-alpha] production in astrocytes caused astrocyte apoptosis , and IL-6 enhanced proliferation of these cells . Positive_regulation TNF APOB 19154986 2027108 The Mtb 19 kDa *induced* release of [tumor necrosis factor] in a manner dependent on both TLR2 and RP105 , and macrophage activation by Mtb lacking mature lipoproteins was not RP105 dependent . Positive_regulation TNF APOB 20398226 2245970 *stimulated* the production of [TNF-alpha] only in infected macrophages , whereas HDL stimulated the production of lower amounts of TNF-alpha in both infected and uninfected macrophages . Positive_regulation TNF APOB 2269351 147325 Acetyl also *induced* the expression of immunoreactive [TNF] , reaching a sevenfold maximum above control at 12 hours following a 6 hour exposure period . Positive_regulation TNF APOB 23376721 2754703 The aim of this study is to evaluate the effect of simvastatin on the *induced* ER stress and expression and secretion of [TNF-a] and MCP-1 in 3T3-L1 adipocytes . Positive_regulation TNF APOB 23376721 2754705 In conclusion , can *stimulate* the expression and secretion of [TNF-a] and MCP-1 through its activation of ER stress in adipocytes . Positive_regulation TNF APOB 23378457 2713037 Clove , ginger , rosemary , and turmeric were able to significantly reduce oxidized *induced* expression of [TNF-a] . Positive_regulation TNF APOB 23816956 2815702 *increased* the expression of TLR4 and secretion of MCP-1 , [TNF-a] and IL-6 . Positive_regulation TNF APOB 23872072 2835311 CSE overexpression reduced the *stimulated* [tumor necrosis factor-a (TNF-a)] generation in Raw264.7 and primary macrophage while CSE knockdown enhanced it . Positive_regulation TNF APOB 24349299 2881255 Further , active [TNF-a] , IL-6 , monocyte chemoattractant protein-1 and matrix metalloproteinase-9 expression *induced* by were attenuated by vinpocetine in a dose dependent manner . Positive_regulation TNF APOB 7704977 297594 In conclusion , human macrophages are efficiently *activated* by , as reflected by the release of IL-1 beta and [TNF alpha] and by the release of oxygen active radicals . Positive_regulation TNF APOB 8977464 403389 Human monocytes/macrophages release [TNF-alpha] in *response* to . Positive_regulation TNF APOB 8977464 403391 also *stimulated* monocyte/macrophage release of [TNF-alpha] in a dose dependent manner , with maximal effect at an LDL concentration of 8 micrograms/mL . Positive_regulation TNF APOB 8977464 403392 *Stimulation* of [TNF-alpha] release by was associated with activation of transcription factor AP-1 , whereas the activity of transcription factor nuclear factor-kB remained unchanged . Positive_regulation TNF APOB 9186079 436769 Exposure to VLDL , IDL , LDL , or a high concentration of HDL enhanced the secretion of interleukin-6 , platelet derived growth factor , and transforming growth factor-beta by mesangial cells , whereas [tumor necrosis factor-alpha] secretion was *stimulated* by oxidized . Positive_regulation TNF APOB 9488215 476501 The addition of lacidipine to human umbilical vein endothelial cells significantly reduced the expression of ICAM-1 , VCAM-1 and E-selectin *induced* by [TNF-alpha] alone or with oxidized ( P < 0.001 ) . Positive_regulation TNF APOB 9578494 503259 Involvement of calcium and arachidonate metabolism in *stimulated* [tumor-necrosis-factor-alpha] production by rat peritoneal macrophages . Positive_regulation TNF APOB 9578494 503265 Acetylated *induced* Ca2+ influx and [TNF-alpha] production were abolished by inhibitors of phospholipase C ( U73122 ) and phospholipase A2 ( bromophenacyl bromide ) , but were not affected by an inhibitor of protein kinase C ( calphostine C ) . Positive_regulation TNF APOB 9925653 581359 High density ( HDL ) or alone *inhibited* the ability of LPS to stimulate [TNF] production , but had little effect on the activation by LTA . Positive_regulation TNF APOBEC2 21469143 2538521 Together with the fact that the proinflammatory cytokine [tumor necrosis factor-a] *induces* ectopic expression of in hepatocytes , our findings indicate that aberrant APOBEC2 expression causes nucleotide alterations in the transcripts of the specific target gene and could be involved in the development of human hepatocellular carcinoma through hepatic inflammation . Positive_regulation TNF APOE 17138935 1686846 Cultured human aortic endothelial cells were stimulated with [tumor necrosis factor (TNF)-alpha] in the *presence* of human recombinant solubilized in dimyristoyl phosphatidylcholine liposomes . Positive_regulation TNF APOE 23619428 2795429 We observed that the absence of *resulted* in the increased proportion of Th1 and Th17 cells in the spleens and brains , as well as up-regulated expressions of proinflammatory cytokines ( IL-17 , IFN-? , [TNF-a] , IL-12 , IL-1ß and IL-6 ) and transcription factors ( ROR?t and T-bet ) in the CNS . Positive_regulation TNF APP 11967279 933128 Both the cytokine interferon-gamma and the lysosomotropic drug chloroquine , but not the cytokines interleukin (IL)-1 , IL-6 , or [tumor necrosis factor-alpha (TNF-alpha)] , *induced* an accumulation of in newly formed multivesicular body-like organelles . Positive_regulation TNF APP 19862700 2165596 Furthermore , [TNFalpha] *induced* mRNA expression dose-dependently with maximal 6.4-fold upregulation seen at 100 ng/ml effector . Positive_regulation TNF APP 7507969 244650 Neither nor tilorone *induced* [TNF] or IL-6 . Positive_regulation TNF AQP1 12635141 1068489 In vitro studies revealed that both MIF and [TNF-alpha] *induced* a small increase of synthesis in cultured endothelial cells . Positive_regulation TNF AQP9 20181673 2236793 as an aquaglyceroporin was *induced* by [TNF-alpha] . Positive_regulation TNF ARF1 14764737 1207399 We therefore hypothesized that LPS induced *requires* systemic [TNF] release triggered by LPS acting on extrarenal TLR4 . Positive_regulation TNF ARF3 14764737 1207400 We therefore hypothesized that LPS induced *requires* systemic [TNF] release triggered by LPS acting on extrarenal TLR4 . Positive_regulation TNF ARF4 14764737 1207401 We therefore hypothesized that LPS induced *requires* systemic [TNF] release triggered by LPS acting on extrarenal TLR4 . Positive_regulation TNF ARF5 14764737 1207402 We therefore hypothesized that LPS induced *requires* systemic [TNF] release triggered by LPS acting on extrarenal TLR4 . Positive_regulation TNF ARF6 14764737 1207403 We therefore hypothesized that LPS induced *requires* systemic [TNF] release triggered by LPS acting on extrarenal TLR4 . Positive_regulation TNF ARFRP1 22301002 2565158 could not only significantly inhibit the growth of H22 transplantable tumor , but also remarkably *promote* splenocytes proliferation , NK cell and CTL activity , as well as serum IL-2 and [TNF-a] production in tumor bearing mice . Positive_regulation TNF ARG1 10857856 704651 GLN , , and OKG all *restored* [TNF-alpha] secretion by macrophages of glucocorticoid treated rats . Positive_regulation TNF ARG1 17218616 1732546 Our results demonstrate that reduction of activity enhanced cellular content of NO and S-nitrosated proteins , and *resulted* in decreases in [TNF-alpha-] or LPS stimulated NF-kappaB DNA binding and transcriptional activity , in association with enhanced S-nitrosation of p50 . Positive_regulation TNF ARG1 22069588 2362465 Both and Lys-gingipain preparations *induced* the secretion of [TNF-a] and IL-8 by macrophages . Positive_regulation TNF ARG1 23760286 2870588 inhibition in diabetic eNOS-knockout mice failed to affect any of these parameters , but *reduced* kidney macrophage recruitment and kidney [TNF-a] expression compared with vehicle treated diabetic eNOS-knockout mice . Positive_regulation TNF ARG2 10857856 704652 GLN , , and OKG all *restored* [TNF-alpha] secretion by macrophages of glucocorticoid treated rats . Positive_regulation TNF ARG2 17218616 1732547 Our results demonstrate that reduction of activity enhanced cellular content of NO and S-nitrosated proteins , and *resulted* in decreases in [TNF-alpha-] or LPS stimulated NF-kappaB DNA binding and transcriptional activity , in association with enhanced S-nitrosation of p50 . Positive_regulation TNF ARG2 22069588 2362466 Both and Lys-gingipain preparations *induced* the secretion of [TNF-a] and IL-8 by macrophages . Positive_regulation TNF ARG2 23760286 2870589 inhibition in diabetic eNOS-knockout mice failed to affect any of these parameters , but *reduced* kidney macrophage recruitment and kidney [TNF-a] expression compared with vehicle treated diabetic eNOS-knockout mice . Positive_regulation TNF ARSA 15024038 1257101 The area of *induced* gastric lesions , gastric blood flow ( GBF ) , expression of mRNA and protein of leptin and plasma leptin , gastrin , interleukin-1beta , and [tumor necrosis factor-alpha] levels were examined . Positive_regulation TNF ARSH 10094246 601100 Coal fly and copper smelter dust *induced* modulation of ex vivo production of [tumor necrosis factor-alpha] by murine macrophages : effects of metals and overload . Positive_regulation TNF ASS1 17354225 1727241 Here , we show that [TNF-alpha] also *induces* expression of arate limiting enzyme in arginine synthesis , , thereby linking inflammation with several arginine dependent metabolic pathways , implicated in accelerated carcinogenesis and tumour progression . Positive_regulation TNF ATF1 22198289 2558675 In addition , IL-1ß and [TNF-a/CHX] *induced* the phosphorylation of ( ATF-2 ) , but not c-Jun . Positive_regulation TNF ATF2 10521481 653104 The study presented here shows that autoregulation of [TNF-alpha] gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 mitogen activated protein (MAP) kinase activity and the binding of the transcription factors and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation TNF ATF2 10871852 708317 We recently demonstrated that through up-regulation of [TNFalpha] , *increases* the resistance of late stage melanoma cells to apoptosis induced by UV-irradiation . Positive_regulation TNF ATF2 14519430 1147715 With ANGII , binding of to the CRE site was *required* for [TNF-alpha] gene induction ; Positive_regulation TNF ATF2 20068037 2235138 Nef *inhibits* ASK1/p38 MAPK dependent Mtb induced [TNF-alpha] production probably by inhibiting binding of to the TNF-alpha promoter . Positive_regulation TNF ATF2 22198289 2558676 In addition , IL-1ß and [TNF-a/CHX] *induced* the phosphorylation of ( ATF-2 ) , but not c-Jun . Positive_regulation TNF ATF2 8552071 347103 [Tumor necrosis factor] alpha gene regulation in activated T cells *involves* and NFATp . Positive_regulation TNF ATF2 9006914 410768 [TNFalpha] stimulation of endothelial cells *induces* transient phosphorylation of both and c-JUN and induces marked activation of the c-JUN N-terminal kinase ( JNK1 ) and p38 but not extracellular signal regulated kinase ( ERK1 ) . Positive_regulation TNF ATF2 9317150 456269 In human endothelial cells , [TNF] rapidly *induces* N-terminal domain phosphorylation of both c-Jun and . Positive_regulation TNF ATF3 22198289 2558677 In addition , IL-1ß and [TNF-a/CHX] *induced* the phosphorylation of ( ATF-2 ) , but not c-Jun . Positive_regulation TNF ATF3 24196350 2875687 PGF treatment in vitro increased ATF3 expression only in LLC , whereas [TNF] *induced* in both SLCs and LLCs . Positive_regulation TNF ATF4 22198289 2558678 In addition , IL-1ß and [TNF-a/CHX] *induced* the phosphorylation of ( ATF-2 ) , but not c-Jun . Positive_regulation TNF ATF4 24080827 2847611 Simultaneous silencing of and CHOP *prevented* upregulation of [TNF-a] . Positive_regulation TNF ATF4 24080827 2847613 Our data therefore revealed a role of ER stress and ATF4/CHOP in the ethanol induced inhibition of osteogenesis , and *activation* of [TNF-a] signaling by linking ER stress to adipogenic lineage in response to alcohol stimulation . Positive_regulation TNF ATF5 22198289 2558679 In addition , IL-1ß and [TNF-a/CHX] *induced* the phosphorylation of ( ATF-2 ) , but not c-Jun . Positive_regulation TNF ATF6 22198289 2558680 In addition , IL-1ß and [TNF-a/CHX] *induced* the phosphorylation of ( ATF-2 ) , but not c-Jun . Positive_regulation TNF ATF7 22198289 2558681 In addition , IL-1ß and [TNF-a/CHX] *induced* the phosphorylation of ( ATF-2 ) , but not c-Jun . Positive_regulation TNF ATP5O 15701621 1372569 Moreover , inhibitors of MLCK , Mg ( 2+ ) -myosin , and metabolic energy *prevented* the [TNF-alpha] increase in Caco-2 TJ permeability , suggesting that the increase in MLCK activity was required for the TNF-alpha induced opening of the Caco-2 TJ barrier . Positive_regulation TNF ATP5O 22351078 2561124 The aim of this study was to investigate the *role* of signaling in myocardial [TNF-a] expression during endotoxemia . Positive_regulation TNF ATP7A 16111636 1448527 A selective inhibitor or siRNA mediated knockdown of Mnk1 *inhibits* [TNFalpha] production in T cells , whereas Mnk1 overexpression enhances expression of a reporter construct containing the TNFalpha 3'UTR . Positive_regulation TNF ATP8A2 11504795 847880 Recombinant , but not the recombinant B-chain alone , also *increased* [TNF-alpha] release and decreased IL-10 release . Positive_regulation TNF ATP8A2 8352018 227261 ) *induced* the release of [TNF] from PA-primed mouse peritoneal macrophages in dose- and time dependent manners in vitro , and the effects of TPA and LPS were inhibited by H-7 ( 12.5-100 mumol . Positive_regulation TNF ATP8A2 8933823 344960 Regarding cytokine secretion , IL-6 and [TNF-alpha] production was *induced* by 10 ng/ml . Positive_regulation TNF ATP8A2 9848688 554043 RAW 264.7 cells ( 2 x 10 ( 5 ) cells ml(-1) ) were stimulated with these LPS preparations at 1 microg for 48 h. Re595 LPS , Re595 LA and Re595 MPLA significantly *induced* NO , [TNF-alpha] and IL-6 production ; Positive_regulation TNF AURKC 21715338 2465905 CCAAT/enhancer binding protein delta mediates [tumor necrosis factor] alpha *induced* transcription and promotes genomic instability . Positive_regulation TNF AVP 24223928 2865222 In the CP epithelial cell cultures , *augmented* the [tumor necrosis factor-a-] and interleukin-1ß dependent increase in synthesis of proinflammatory mediators , including neutrophil chemoattractants , an action largely dependent on the JNK signaling pathway . Positive_regulation TNF AZU1 10201953 605708 In the current study , we hypothesize that HBP is internalized in monocytes via endocytosis , and this internalization is an important mechanism by which *enhances* LPS induced [TNF-alpha] release . Positive_regulation TNF AZU1 18787642 1969331 Mechanistically , and HNP1-3 *triggered* macrophage release of [TNF-alpha] and IFN-gamma , which acted in an autocrine loop to enhance expression of CD32 and CD64 and thereby enhance phagocytosis . Positive_regulation TNF B4GALT1 15668241 1382114 Our data show that [TNFalpha] *induced* an increase in the expression of ( beta4GalT-1 ) in primary human umbilical vein endothelial cells in a time- and concentration dependent manner . Positive_regulation TNF BAD 10383455 624599 [Tumor necrosis factor (TNF)] *induced* the phosphorylation of at serine 136 in HeLa cells under conditions that are not cytotoxic . Positive_regulation TNF BAMBI 24448807 2932993 ChIP analysis revealed that LPS and [TNF-a] *induced* binding of the NF-?Bp50/p50 homodimer to the promoter region . Positive_regulation TNF BANF1 7694969 297258 The abilities of adPIC and to *induce* [tumor necrosis factor (TNF)] in vivo and in cultured macrophages were compared . Positive_regulation TNF BANP 20006573 2199867 Further , we show that [TNFalpha] stimulation *induces* phosphorylation at Ser-347 and promotes its cytoplasmic translocation , thus releasing its negative effect . Positive_regulation TNF BAX 10949027 723245 Rather , [TNF-alpha] *induced* a tBid dependent conformational change in that allowed an interaction between E1B 19K and conformationally altered Bax , which caused inhibition of cytochrome c release and caspase-9 activation . Positive_regulation TNF BAX 11571294 882323 [Tumor necrosis factor-alpha] *induces* interaction and apoptosis , which is inhibited by adenovirus E1B 19K . Positive_regulation TNF BAX 11571294 882331 [TNF-alpha] *induces* E1B <19K-Bax> interaction and inhibits Bax oligomerization . Positive_regulation TNF BAX 19334572 2052858 The results suggest that HeLa apoptosis was induced by [tumor necrosis factor-a] and interferon -gamma , and the increasing expression of P53 may *induce* the expression of and prevent the expression of Bcl-2 , via the mitochondrial induction of cell apoptosis . Positive_regulation TNF BCL10 10085086 599321 [Tumor necrosis factor] *induces* Bcl-2 and expression through NFkappaB activation in primary hippocampal neurons . Positive_regulation TNF BCL10 17623099 1787122 The expression profile suggested PI3K/AKT activation and NF-kappaB activation through multiple pathways ( TLR/IL1R , [TNF] receptor induced and TCR-like possibly *involving* ) . Positive_regulation TNF BCL10 18951565 1989240 Renal obstruction *induced* increased [tumor necrosis factor-alpha] production , apoptotic renal tubular death , the expression of Bax , caspase 8 and truncated BID , and mitochondrial release of cytochrome C , while simultaneously stimulating decreased Bcl-2 and ( L ) expression . Positive_regulation TNF BCL10 20363734 2266644 We found that either PP2A inhibitor okadaic acid or depletion of catalytic subunit alpha of PP2A ( PP2A/Calpha ) by small interfering RNA enhanced ( L ) phosphorylation when activated with hydrogen peroxide and [tumor necrosis factor] alpha *induced* oxidative stress . Positive_regulation TNF BCL10 20937806 2353619 [TNF-a] induced the ubiquitination of TRAF2 ( TNF receptor associated factor 2 ) , which interacts with NIK , and CGN *induced* phosphorylation of , leading to increased NIK phosphorylation . Positive_regulation TNF BCL10 9873064 583473 In the *presence* of , [TNFalpha] still induced BID cleavage and p15 BID became an integral mitochondrial membrane protein . Positive_regulation TNF BCL2 10085086 599322 [Tumor necrosis factor] *induces* and Bcl-x expression through NFkappaB activation in primary hippocampal neurons . Positive_regulation TNF BCL2 18951565 1989241 Renal obstruction *induced* increased [tumor necrosis factor-alpha] production , apoptotic renal tubular death , the expression of Bax , caspase 8 and truncated BID , and mitochondrial release of cytochrome C , while simultaneously stimulating decreased and Bcl-x ( L ) expression . Positive_regulation TNF BCL2 9850096 554274 It was demonstrated that overexpression of in either HL-60 or PW leukemia cell lines *suppressed* activation of AP24 induced by either [tumor necrosis factor] or UV light and protected cells from apoptosis . Positive_regulation TNF BCL2 9873064 583474 In the *presence* of , [TNFalpha] still induced BID cleavage and p15 BID became an integral mitochondrial membrane protein . Positive_regulation TNF BCL2A1 16924232 1692188 [TNF] *induced* the expression of NF-kappaB regulated gene products cyclin D1 , c-Myc , matrix metalloproteinase-9 , survivin , X-linked inhibitor-of-apoptosis protein ( IAP ) , IAP1 , Bcl-x ( L ) , and Fas associated death domain protein-like IL-1beta converting enzyme-inhibitory protein in wild-type MEF but not in PKR-/- cells . Positive_regulation TNF BCL3 12907458 1163971 IL-10-inducible negatively *regulates* LPS induced [TNF-alpha] production in macrophages . Positive_regulation TNF BCL3 12907458 1163973 Overexpression of *suppressed* activation of the [TNF-alpha] promoter , but not the IL-6 promoter . Positive_regulation TNF BCL3 19191868 2061283 was *induced* in myeloma cell lines by interleukin (IL)-6 , IL-21 , IL-15 , [tumor necrosis factor-alpha] and IGF-1 , and its upregulation was associated with increased proliferation of the cells . Positive_regulation TNF BCL3 9873064 583475 In the *presence* of , [TNFalpha] still induced BID cleavage and p15 BID became an integral mitochondrial membrane protein . Positive_regulation TNF BCL5 9873064 583470 In the *presence* of , [TNFalpha] still induced BID cleavage and p15 BID became an integral mitochondrial membrane protein . Positive_regulation TNF BCL6 9873064 583471 In the *presence* of , [TNFalpha] still induced BID cleavage and p15 BID became an integral mitochondrial membrane protein . Positive_regulation TNF BCL9 9873064 583472 In the *presence* of , [TNFalpha] still induced BID cleavage and p15 BID became an integral mitochondrial membrane protein . Positive_regulation TNF BDNF 18040799 1669143 Activation of NF-kappaB by TNF-alpha and inhibition of TNF-alpha induced BDNF expression by Deltap65 ( a dominant negative mutant ) and NEMO binding domain peptide ( an inhibitor of NF-kappaB ) suggests that [TNF-alpha] *induces* expression through the activation of NF-kappaB . Positive_regulation TNF BDNF 21335064 2410950 [Tumor necrosis factor-a] *increases* expression in trigeminal ganglion neurons in an activity dependent manner . Positive_regulation TNF BGN 16025156 1435601 Here we show that acts in macrophages as an endogenous ligand of TLR4 and TLR2 , which mediate innate immunity , leading to rapid activation of p38 , ERK , and NF-kappaB and thereby *stimulating* the expression of [TNF-alpha] and macrophage inflammatory protein-2 ( MIP-2 ) . Positive_regulation TNF BIRC2 15861135 1404150 [TNF-alpha] *induced* complex translocation to a Ubc6 containing compartment and TRAF2 ubiquitination . Positive_regulation TNF BIRC2 17133355 1677741 In human endothelial cells , [TNF-alpha] *induced* and c-IAP2 , but not XIAP and TIAP/Survivin , at the transcriptional level . Positive_regulation TNF BIRC2 17934460 1819719 Using genetic and molecular approaches , we show that positively *regulates* the formation of the [TNF] receptor complex I in endothelial cells , thereby promoting NF-kappaB activation and maintaining vessel integrity and stabilization . Positive_regulation TNF BIRC2 18827186 2012752 Here we show that , once in the cytoplasm , is *involved* in the degradation of the adaptor protein [tumor necrosis factor] receptor associated factor 2 ( TRAF2 ) by the proteosomal machinery . Positive_regulation TNF BIRC2 20356846 2266537 [Tumor necrosis factor (TNF)] signaling , but not TWEAK ( TNF-like weak inducer of apoptosis ) -triggered cIAP1 ( cellular inhibitor of apoptosis protein 1 ) degradation , *requires* RING dimerization and E2 binding . Positive_regulation TNF BIRC2 24497535 2928358 Loss of inhibitor of apoptosis proteins ( IAPs ) , particularly , can *promote* production of [tumor necrosis factor (TNF)] and sensitize cancer cell lines to TNF induced necroptosis by promoting formation of a death inducing signaling complex containing receptor interacting serine/threonine-protein kinase ( RIPK) 1 and 3 . Positive_regulation TNF BIRC3 11359809 816342 [TNF] *induced* expression of the antiapoptotic protein ( cytoplasmic inhibitor of apoptosis protein 2 ) , and was blocked in the presence of a p38 MAPK inhibitor , which also induced caspase dependent , TNF mediated apoptosis in U937 cells . Positive_regulation TNF BIRC3 17133355 1677742 In human endothelial cells , [TNF-alpha] *induced* c-IAP1 and , but not XIAP and TIAP/Survivin , at the transcriptional level . Positive_regulation TNF BIRC3 21279667 2419773 We demonstrate that in the absence of p65 , [TNF-a] *induced* expression is significantly reduced while the levels of Bcl-2 , Bcl-xL and Survivin are not affected . Positive_regulation TNF BIRC3 23250032 2737207 [TNF-a] selectively *induced* in beta cells , which in turn was sufficient to drive and potentiate NF-?B reporter activity . Positive_regulation TNF BIRC3 23597429 2789710 Here , we show that pro-inflammatory cytokine [TNF-a] *induced* the up-regulation of in the potential metastatic nasopharyngeal carcinoma (NPC) cells in a dose- and time dependent manner . Positive_regulation TNF BIRC3 9294162 452905 These findings suggest that is critically *involved* in [TNF] signaling and exerts positive feedback control on NF-kappaB via an IkappaB targeting mechanism . Positive_regulation TNF BLM 10600896 574093 induces lung injury and fibrosis in the murine lung and *enhances* [tumor necrosis factor (TNF)-alpha] and collagen mRNA expression in the murine lung . Positive_regulation TNF BLM 10991907 732884 Furthermore , curcumin remarkably suppressed the *induced* alveolar macrophage production of [TNF-alpha] , superoxide and nitric oxide . Positive_regulation TNF BLM 15770542 1384370 Moreover , IL also significantly inhibited the overexpression of [TNF-alpha] and TGF-beta (1) *induced* by . Positive_regulation TNF BLM 15770542 1384372 These results indicated that IL possessed a significant inhibitory effect on BLM induced pulmonary fibrosis , probably due to its antioxidant and/or anti-inflammatory activities and inhibitory overexpressing [TNF-alpha] and TGF-beta (1) *induced* by . Positive_regulation TNF BLM 17569781 1763248 Studies conducted in mice revealed that MSC administration was more effective than recombinant IL1RN delivered via adenoviral infection or osmotic pumps in inhibiting *induced* increases in [TNF-alpha] , IL-1alpha , and IL1RN mRNA in lung , IL1RN protein in bronchoalveolar lavage (BAL) fluid , and trafficking of lymphocytes and neutrophils into the lung . Positive_regulation TNF BLM 18974632 2053254 PGZ also inhibited *induced* [TNF-alpha] production in alveolar macrophages . Positive_regulation TNF BLM 23997916 2836681 could significantly *increase* the levels of [TNF-a] and TGF-ß1 and decrease the PGE2 concentration compared to the saline control group . Positive_regulation TNF BLM 9839161 552615 These animals demonstrated an increased expression of [TNF] , but not TGF-beta 1 , mRNA in *response* to and did not exhibit histologic evidence of lung injury following BLM exposure . Positive_regulation TNF BMP1 16785566 1577167 AMphi derived from STAT1-deficient mice did not demonstrate increased production of [TNF-alpha] in *response* to plus IFN-beta . Positive_regulation TNF BMP1 22687552 2643703 *increased* the production of nitric oxide ( NO ) and the gene expression of IL-1ß , IL-6 , and [TNF-a] in RAW 264.7 cells . Positive_regulation TNF BMP2 15316669 1286286 IL-1 , but not [TNF-alpha] , can *induce* IL-6 , , and cyclooxygenase ( COX-2 ) expression in SW1353 cells . Positive_regulation TNF BMP2 16835229 1606483 Pro-inflammatory cytokine [tumor necrosis factor-alpha] *induces* in chondrocytes via mRNA stabilization and transcriptional up-regulation . Positive_regulation TNF BMP2 16835229 1606486 In ATDC5 cells , the endogenous expression was consistently low throughout the process of chondrogenic differentiation , and [TNF-alpha] *induced* BMP-2 expression only after the cells acquired the chondrogenic phenotype . Positive_regulation TNF BMP2 20304956 2254869 Indeed , [TNF-alpha] could induce BMP-2 and its receptor ( BMPR1A ) in human skin and primary keratinocytes , and could *induce* EMT features in skin explants and primary keratinocytes . Positive_regulation TNF BMP6 19191909 2127900 In addition , *induced* expression of pro-inflammatory inducible nitric oxide synthase (iNOS) and the cytokine [tumour necrosis factor (TNF)-alpha] . Positive_regulation TNF BMP7 15574511 1355716 [TNF-alpha] stimulation of PTC in the *presence* of failed to increase monocyte dependent TGF-beta1 stimulation . Positive_regulation TNF BMX 14532277 1174862 [TNF] *induces* a coordinated phosphorylation of vascular endothelial growth factor ( VEGF ) receptor 2 ( VEGFR2 ) and , which is blocked by VEGFR2-specific inhibitors . Positive_regulation TNF BMX 14532277 1174883 However , [TNF] *induces* phosphorylation of at Tyr-566 , directly mediating the recruitment of the p85 subunit of PI3K . Positive_regulation TNF BMX 14532277 1174898 Taken together , our data demonstrated that [TNF] induces transactivation between Etk and VEGFR2 , and directly *activates* PI3K-Akt angiogenic signaling independent of VEGF induced VEGFR2-PI3K-Akt signaling pathway . Positive_regulation TNF BMX 16195372 1462894 Wild-type [TNF] *induces* TNFR2 and and activates both ASK1 and Etk but does not down-regulate TNFR1 . Positive_regulation TNF BPI 9366436 463314 Confirming earlier published studies , inhibited , and LBP enhanced , the ability of LPS to *stimulate* PBMC production of the cytokines [TNF-alpha] and IL-6 . Positive_regulation TNF BTD 19317165 2007717 can *regulate* [TNF-alpha] and TGF-beta1 levels to suppress the immune inflammatory reaction so as to treat AS . Positive_regulation TNF BTK 11036165 741141 These findings indicate that rather than a PKC dependent mechanism is *involved* in the modulation of [TNFalpha] response by IFbeta-1a on BMECs . Positive_regulation TNF BTK 12810683 1102843 We examined the *role* of in [TNF alpha] production using luciferase reporter adenoviral constructs and have established that overexpression of Btk results in the stabilization of TNF alpha mRNA via the 3 ' untranslated region . Positive_regulation TNF BTK 16751014 1570741 We show that in *response* to LPS , monocytes from patients with XLA induce early mitogen activated protein kinase activation and intracellular [TNF-alpha] and IL-6 production with the same intensity as cells from age- and sex matched control subjects . Positive_regulation TNF BTK 17725607 1848799 In this study we set out to investigate the potential *role* of in Toll-like receptor 9 (TLR9) activation and the production of pro-inflammatory cytokines such as interleukin (IL)-6 , [tumour necrosis factor (TNF)-alpha] and IL-12p40 . Positive_regulation TNF BTLA 24315996 2880134 also negatively *regulated* IL-17 and [TNF] production in CD27 ( - ) ?d T cells . Positive_regulation TNF BTRC 10889302 710425 However , we observed that used as a co-stimulus significantly *potentiated* histamine and [TNF-alpha] release in canine MC activated through Fc epsilon RI regardless of whether or not SCF was added to the medium during culturing . Positive_regulation TNF BTRC 11763385 887882 Moreover , [TNF-alpha] *induced* expression of CD54 by cells in the medium , but not by those retained in the sheets , whereas human induced , dose dependently , expression of CD54 by cells in the sheets , but not from those in the medium . Positive_regulation TNF BTRC 16436136 1516383 Either SCF or [TNF-alpha] could *induce* release from HMC-1 cells of interleukin (IL)-8 , monocyte chemoattractant protein (MCP)-1 , regulated upon activation normal T-cell expressed and secreted ( RANTES ) , and I-309 , while and TNF-alpha induced release of macrophage inflammatory protein (MIP)-1beta and interferon-gamma-inducible protein-10 (IP-10) , respectively . Positive_regulation TNF BTRC 17320132 1719745 In addition , production of [tumor necrosis factor (TNF)-alpha] , interleukin (IL)-1beta , and vascular endothelial growth factor ( VEGF ) production *induced* by was significantly inhibited by treatment with SC-236 . Positive_regulation TNF BTRC 18549896 1923755 In vitro studies using primary mouse hepatocytes show that is *induced* by [TNF-alpha] ; Positive_regulation TNF BTRC 8809429 383142 Changes in the level of mastocytoma mRNA for [TNF alpha] in *response* to stimulation with or fibroblast conditioned media for up to 12 weeks were studied using Northern analysis and changes in the level of TNF alpha protein expression on immunoblot and immunocytochemistry . Positive_regulation TNF BTRC 9637535 513873 was constitutively produced from fibroblasts in its transmembrane form and could be *induced* by [TNF] . Positive_regulation TNF BTRC 9759885 536634 Coligation of SCFR augmented Fc epsilonRI mediated activation of MAP kinases , especially JNK activation , and *augmented* Fc epsilonRI mediated [TNF-alpha] production in MC/9 cells , although SCF alone did not induce TNF-alpha production . Positive_regulation TNF BUD31 8766549 374984 In contrast , neither mAb <10G10> , which recognizes an epitope distinct from the one recognized by mAb 4B2 , nor mAb UCHL-1 , a CD45RO-specific antibody , induced any significant *increase* in [TNF-alpha] transcription . Positive_regulation TNF C12orf57 11035713 741080 In vitro studies showed that the combination of IL-1beta and C10 markedly augmented [TNF-alpha] synthesis by peritoneal macrophages and that synthesis was *induced* in these cells following their exposure to IL-13 . Positive_regulation TNF C12orf57 21132269 2372989 The *activation* of nuclear factor of ? light polypeptide gene enhancer in B-cells inhibitor , a , by [tumor necrosis factor-a] or VEGF in these cells was also blocked by . Positive_regulation TNF C1orf228 15963988 1428206 [TNF-alpha] enhances phenotypic and functional maturation of human epidermal Langerhans cells and *induces* IL-12 and IP-10/CXCL-10 production . Positive_regulation TNF C1QA 10898508 712099 Studying the functional consequences of the interaction , we found that the release of [TNF-alpha] from Mphi is *induced* by but not by MBL . Positive_regulation TNF C1QA 17383729 1735477 Immobilized *induced* maturation of MDCs and enhanced secretion of IL-12 and [TNF-alpha] , moreover , elevated their T-cell stimulating capacity . Positive_regulation TNF C1QA 19919576 2190032 Microglia added to C1q coated wells or fed apoptotic neurons or neuronal blebs coated with C1q suppressed the lipopolysaccharide induced production of proinflammatory cytokines interleukin (IL)-1alpha , IL-1beta , IL-6 and [TNF-alpha] , while the presence of *enhanced* levels of the chemokine MCP-1/CCL2 . Positive_regulation TNF C1QA 8225388 234853 Inhibitor of C1q secretion suppresses the macrophage response to lipid A for nitric oxide but not for TNF production : evidence for a *role* of in autocrine binding of [TNF] . Positive_regulation TNF C1QA 8225388 234859 C1q was confirmed to bind to macrophages at 4 degrees C as detected by FITC anti-C1q , F ( ab ' ) 2 and such binding *promoted* a corresponding increased binding of [PE-TNF] . Positive_regulation TNF C1QA 8225388 234861 Since TNF binding to DHP treated macrophages was reconstituted by the binding of exogenous C1q to the cells , it appears that may be *involved* in the modulation of autocrine binding of [TNF] for subsequent generation of cytotoxic NO . Positive_regulation TNF C1QA 8603439 352187 The *role* of complement subcomponent in the modulation of [TNF-alpha] binding to L929 cells to mediate cytotoxicity and nitric oxide ( NO ) generation was investigated . Positive_regulation TNF C1QA 8711421 376621 In the present study , the putative *role* of in increasing [TNF-alpha] binding to L929 cells to mediate cytotoxicity was explored . Positive_regulation TNF C1QB 10898508 712100 Studying the functional consequences of the interaction , we found that the release of [TNF-alpha] from Mphi is *induced* by but not by MBL . Positive_regulation TNF C1QB 17383729 1735478 Immobilized *induced* maturation of MDCs and enhanced secretion of IL-12 and [TNF-alpha] , moreover , elevated their T-cell stimulating capacity . Positive_regulation TNF C1QB 19919576 2190033 Microglia added to C1q coated wells or fed apoptotic neurons or neuronal blebs coated with C1q suppressed the lipopolysaccharide induced production of proinflammatory cytokines interleukin (IL)-1alpha , IL-1beta , IL-6 and [TNF-alpha] , while the presence of *enhanced* levels of the chemokine MCP-1/CCL2 . Positive_regulation TNF C1QB 8225388 234854 Inhibitor of C1q secretion suppresses the macrophage response to lipid A for nitric oxide but not for TNF production : evidence for a *role* of in autocrine binding of [TNF] . Positive_regulation TNF C1QB 8225388 234860 C1q was confirmed to bind to macrophages at 4 degrees C as detected by FITC anti-C1q , F ( ab ' ) 2 and such binding *promoted* a corresponding increased binding of [PE-TNF] . Positive_regulation TNF C1QB 8225388 234862 Since TNF binding to DHP treated macrophages was reconstituted by the binding of exogenous C1q to the cells , it appears that may be *involved* in the modulation of autocrine binding of [TNF] for subsequent generation of cytotoxic NO . Positive_regulation TNF C1QB 8603439 352188 The *role* of complement subcomponent in the modulation of [TNF-alpha] binding to L929 cells to mediate cytotoxicity and nitric oxide ( NO ) generation was investigated . Positive_regulation TNF C1QB 8711421 376622 In the present study , the putative *role* of in increasing [TNF-alpha] binding to L929 cells to mediate cytotoxicity was explored . Positive_regulation TNF C1QTNF3 19955001 2190770 Serum cholesterol concentration affects the pro-inflammatory potential of LPS to induce [TNF] release from T2D monocytes in the *presence* or absence of . Positive_regulation TNF C1QTNF3 21351204 2499715 significantly and dose-dependently *reduced* LPS induced IL-8 secretion in CLPF within 8 hours after LPS exposure , whereas LPS induced IL-6 and [TNF] release was not affected . Positive_regulation TNF C3 10082594 599097 This study supports the hypothesis that is important in PV acantholysis and that complement activation is *increased* by IL-1alpha and [TNF-alpha] . Positive_regulation TNF C3 10750762 681456 and elastase levels were rapidly increased upon the institution of CPB , and this was *followed* by increases in IL-8 , [TNF-alpha] , and sE-selectin . Positive_regulation TNF C3 18195163 1863344 [Tumor necrosis factor-alpha] *induced* and interleukin-6 expression in VSMCs . Positive_regulation TNF C3 8598489 350734 One hour after the start of the 30-min IL-1 infusion , which caused mild cardiovascular toxicity , plasma levels of IL-6 reached a peak of 25 +/- 9 ng/L ( mean +/- SEM ) , IL-8 reached a peak of 311 +/- 100 ng/L at 2 h , and nitrite/nitrate peaked after 10 h to 89 +/- 27 mumol/L . IL-1 did not *induce* significant changes in plasma levels of [TNF] or of the complement activation products and C4b/c . Positive_regulation TNF C3 8617973 353946 Neither nor C3a desArg alone *induced* detectable protein or mRNA levels for [TNF-alpha] and IL-1 beta . Positive_regulation TNF C3 8617973 353954 In contrast , in adherent PBMC , at 5 to 20 microgram/ml *enhanced* LPS induced [TNF-alpha] ( 75-188 % increase , p less than 0.001 ) and IL-1 beta ( 119-274 % increase , p less than 0.001 ) synthesis . Positive_regulation TNF C3 8617973 353956 *enhanced* [TNF-alpha] and IL-1 beta mRNA levels in LPS stimulated adherent cells . Positive_regulation TNF C3AR1 17498719 1848313 Myofibroblasts in stenotic , but not in control valves , expressed C3aR , and , in isolated myofibroblasts , [TNF-alpha] and cigarette smoke *induced* mRNA expression ( p < 0.05 for both ) . Positive_regulation TNF C4B 8598489 350735 One hour after the start of the 30-min IL-1 infusion , which caused mild cardiovascular toxicity , plasma levels of IL-6 reached a peak of 25 +/- 9 ng/L ( mean +/- SEM ) , IL-8 reached a peak of 311 +/- 100 ng/L at 2 h , and nitrite/nitrate peaked after 10 h to 89 +/- 27 mumol/L . IL-1 did not *induce* significant changes in plasma levels of [TNF] or of the complement activation products C3a and . Positive_regulation TNF C5 10859471 704831 Regarding the biological functions of MCF-pl5-L other than MCA and chemotactic activity for alveolar macrophages , we found that MCF-pl5-L but not and MCP-1 could prolong the life span of alveolar macrophages , probably by inhibiting apoptosis of macrophages , and *stimulate* the production of [TNF-alpha] from macrophages . Positive_regulation TNF C5 10927032 719242 However , in the presence of low concentrations of LPS ( 50 ng/mL ) , both IL-1beta and [TNF-alpha] were *stimulated* by 1 nM . Positive_regulation TNF C5 11207298 786916 Taken together , these results indicate that and C5a ( desArg ) may *increase* the susceptibility of MDM to HIV infection through stimulation of [TNF-alpha] and IL-6 secretion from these cells . Positive_regulation TNF C5 12163370 972335 We conclude that chronic immunoglobulin mediated complement activation in the myocardium may contribute in part to the progression of dilated cardiomyopathy via *induced* [TNF-alpha] expression in cardiac myocytes . Positive_regulation TNF C5 12567272 1057137 Finally , piperlactam S inhibited the *stimulated* release of [tumor necrosis factor-alpha] and interleukin-1beta . Positive_regulation TNF C5 12928416 1132019 The effect of C5a was indirect , since *stimulated* [TNF-alpha] and PGE ( 2 ) were found to be obligatory as well as sufficient to induce differentiation of monocytes . Positive_regulation TNF C5 14527377 1148362 The expression of C5aR in synoviocytes from inflammatory joint diseases and also the *induction* of [TNF alpha] release in activated synoviocytes by the interaction of and C5aR suggest that the C5a/C5aR system may play an important role in joint inflammation process . Positive_regulation TNF C5 16879222 1593943 Experiments with antitumor necrosis factor ( TNF)-alpha antibodies and tiron showed that the effect of was not *mediated* by [TNF-alpha] or oxidative burst . Positive_regulation TNF C5 24043889 2851688 Whereas *enhanced* secretion of LPS induced IL-6 and [TNF] from primary human monocytes , C5a inhibited these responses while increasing IL-10 secretion in donor matched human monocyte derived macrophages differentiated by GM-CSF or M-CSF . Positive_regulation TNF C5 3260938 95974 *stimulates* secretion of [tumor necrosis factor] from human mononuclear cells in vitro . Positive_regulation TNF C5 3260938 95975 Through the mediation of [TNF] and IL-1 secreted in *response* to , these diverse disorders can share common features of fever , coagulopathy , acute phase protein production , and disordered metabolism . Positive_regulation TNF C5 8755663 377431 In the IgG immune complex model , is *required* for the full production of [TNFalpha] and the corresponding upregulation of lung vascular ICAM-1 . Positive_regulation TNF C5AR1 14527377 1148363 The expression of C5aR in synoviocytes from inflammatory joint diseases and also the *induction* of [TNF alpha] release in activated synoviocytes by the interaction of C5a and suggest that the C5a/C5aR system may play an important role in joint inflammation process . Positive_regulation TNF C9orf3 12614218 1065087 or holo-Tf uniformly *induced* [TNF-alpha] secretion in the cell supernatants from both groups . Positive_regulation TNF C9orf3 12773982 1095259 However , ( 2 ) of 150 and 440 mm Hg significantly ( P < .05 ) *increased* lipopolysaccharide stimulated [TNF] and interleukin-6 production versus 45 mm Hg . Positive_regulation TNF CA1 12888335 1117046 It remains unknown , however , whether the myocardial injury associated with *results* in myocardial NF-kappaB activation and [TNF] production . Positive_regulation TNF CA1 15318102 1286378 However , a transient increase of intracellular calcium ( [ ) is *required* for LPS induced [TNF-alpha] production by the macrophage cell line . Positive_regulation TNF CA1 21767946 2579283 Over all , we found could act on macrophages and *regulate* the production of [TNF-a] not only in inflammatory diseases but also in tumour microenvironment , which might be another anti-tumour mechanism of CAI . Positive_regulation TNF CA1 2230595 144623 [TNF] release ( L929 cytolytic assay ) in the *presence* of occurred during the first 3 days of in vitro culture . Positive_regulation TNF CA2 11160247 781562 The expression of [TNF] , in contrast , is *mediated* by PKC , but not by . Positive_regulation TNF CA2 12188028 979950 Verapamil may , therefore , protect against some of the various disturbances *caused* by changes in mobilization through its ability to inhibit [TNFalpha] production in septic shock . Positive_regulation TNF CA2 16442440 1516899 Furthermore , secretion of [TNF-alpha] in M. bovis infected human monocytes was also *dependent* on , and PKA pathways . Positive_regulation TNF CA2 1666506 176529 [TNF-alpha] *induced* rapid elevation of intercellular level in all studied cells . Positive_regulation TNF CA2 20237583 2223931 Interestingly , endothelial nitric oxide synthase (eNOS) promotes TNF-alpha expression by enhancing p38 MAPK activation , whereas neuronal NOS (nNOS) *inhibits* [TNF-alpha] production by reducing dependent ERK1/2 activity . Positive_regulation TNF CA2 20599720 2290812 In addition to Ca2+ mobilization through the IP3-receptor , TRPV2 mediated intracellular mobilization is *involved* in NFkappaB dependent [TNFalpha] and IL-6 expression , while extracellular Ca2+ entry is involved in NFkappaB independent IL-6 production . Positive_regulation TNF CA2 7578678 329224 In conclusion , [TNF alpha] *induces* transient increases in [ ] i by transmembrane Ca2+ flux , which are suppressed during cytodifferentiation . Positive_regulation TNF CA2 8077671 270740 Unlike constitutive secretion , however , the secretion of [TNF] was highly *regulated* by and protein kinase C. Studies with various stimulants and inhibitors indicated that simultaneous mobilization of Ca2+ and activation of protein kinase C were sufficient signals for secretion although optimal production of TNF may be dependent on additional synergistic signals . Positive_regulation TNF CA2 8239612 236127 Germ tube negative mutant *induced* the release of [TNF-alpha] at levels significantly ( P < 0.05 ) lower than those induced by clinical isolate CA3 , while no major differences were observed between the two strains with regard to their capacity to induce the release of IL-6 . Positive_regulation TNF CA2 8660944 371782 These findings suggest that TPT increases intracellular , alters actin polymerization and the cytoskeleton , and *induces* NF-kappaB activation , [TNF-alpha] synthesis , DNA degradation , and apoptosis . Positive_regulation TNF CA2 8858023 388378 Intracellular is *required* for [TNF] protein release by naive macrophages and TNF mRNA transcription of both naive and LPSp reprogrammed cells , however LPSa stimulated IL-1 release in peritoneal macrophages does not require Ca2+ dependent signaling pathways . Positive_regulation TNF CA2 8944708 400247 Endocytosis and are *required* for endotoxin stimulated [TNF-alpha] release by rat Kupffer cells . Positive_regulation TNF CA2 9010006 405065 We conclude that [TNF-alpha] *induces* an increase of intracellular and a depolarization in astrocytes with the consequence of disturbing voltage dependent glial functions such as regulation of local ion concentrations and glutamate uptake . Positive_regulation TNF CA2 9754866 535251 All -- ATPase inhibitors ( TG , CPA , DTBHQ and DTAHQ ) *induced* [TNF-alpha] release in a dose dependent manner . Positive_regulation TNF CA2 9754866 535255 These results suggest 1 ) that [ ] i increase and subsequent activation of protein kinase C is *necessary* for the release of [TNF-alpha] , and they work synergistically , 2 ) that the TNF-alpha release induced by Ca2+-ATPase inhibitors can be regulated at the transcriptional level . Positive_regulation TNF CABIN1 12100723 962432 FK506 , a , and nifedipine , a calcium channel inhibitor , *inhibited* not only the expression of [TNF-alpha] and CD40L , but also the up-regulation of CD80 on irradiated A20-HL cells . Positive_regulation TNF CACNA1A 23333909 2769733 The release of [TNF-a] was markedly *induced* by in a dose dependent manner . Positive_regulation TNF CADM1 20465310 2268804 [TNF-alpha] markedly *induced* protein expression of and E-selectin with increasing mRNA levels in HUVEC . Positive_regulation TNF CADM1 8666424 369085 [TNF-alpha] but not the other human cytokines unregulated swine leucocyte antigens (SLA) class I , class II and B7 receptor expression and *induced* vascular ( VCAM ) and E-selectin expression . Positive_regulation TNF CADM1 9409229 471386 In cultured human smooth muscle cells from coronary arteries and saphenous veins , [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 beta (IL-1 beta) *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation TNF CADM2 20465310 2268802 [TNF-alpha] markedly *induced* protein expression of and E-selectin with increasing mRNA levels in HUVEC . Positive_regulation TNF CADM2 8666424 369083 [TNF-alpha] but not the other human cytokines unregulated swine leucocyte antigens (SLA) class I , class II and B7 receptor expression and *induced* vascular ( VCAM ) and E-selectin expression . Positive_regulation TNF CADM2 9409229 471378 In cultured human smooth muscle cells from coronary arteries and saphenous veins , [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 beta (IL-1 beta) *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation TNF CADM3 20465310 2268801 [TNF-alpha] markedly *induced* protein expression of and E-selectin with increasing mRNA levels in HUVEC . Positive_regulation TNF CADM3 8666424 369082 [TNF-alpha] but not the other human cytokines unregulated swine leucocyte antigens (SLA) class I , class II and B7 receptor expression and *induced* vascular ( VCAM ) and E-selectin expression . Positive_regulation TNF CADM3 9409229 471377 In cultured human smooth muscle cells from coronary arteries and saphenous veins , [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 beta (IL-1 beta) *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation TNF CADM4 20465310 2268803 [TNF-alpha] markedly *induced* protein expression of and E-selectin with increasing mRNA levels in HUVEC . Positive_regulation TNF CADM4 8666424 369084 [TNF-alpha] but not the other human cytokines unregulated swine leucocyte antigens (SLA) class I , class II and B7 receptor expression and *induced* vascular ( VCAM ) and E-selectin expression . Positive_regulation TNF CADM4 9409229 471379 In cultured human smooth muscle cells from coronary arteries and saphenous veins , [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 beta (IL-1 beta) *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation TNF CALB1 15225809 1268470 Our findings suggest that is capable of directly inhibiting the activity of caspase-3 , a common downstream effector of multiple apoptotic signaling pathways , and that this inhibition *results* in an inhibition of [tumor necrosis factor] ( TNFalpha ) and glucocorticoid induced apoptosis in bone cells . Positive_regulation TNF CALD1 23512754 2895535 In macrophages , levels of [TNF-a] , IFN-? , NO , IL-6 and IL-10 were *increased* by used alone or in combination with HSV-2 . Positive_regulation TNF CALM3 10718374 676663 Here , we investigated the effect of adherence on *dependent* protein kinase ( CaMK ) II and IV activation of the extracellular-signal regulated kinase ( ERK) 1/2 cascade and on lipopolysaccharide (LPS) induced [TNFalpha] production by human monocytes . Positive_regulation TNF CALM3 16421203 1554179 Functional link between [TNF] biosynthesis and dependent *activation* of inducible nitric oxide synthase in RAW 264.7 macrophages . Positive_regulation TNF CALM3 16421203 1554192 Increasing the level of cellular by stable transfection *results* in reductions in LPS induced expression of [TNF] and iNOS , along with reduced activation of their transcriptional regulators and concomitant protection against apoptosis . Positive_regulation TNF CALM3 16442440 1516895 Activation of ERK1/2 and [TNF-alpha] production are *mediated* by , and PKA signaling pathways during Mycobacterium bovis infection . Positive_regulation TNF CALM3 16442440 1516900 Furthermore , secretion of [TNF-alpha] in M. bovis infected human monocytes was also *dependent* on , and PKA pathways . Positive_regulation TNF CALM3 8237376 236055 These results suggest that the LPS induced release of [TNF] is *dependent* and PKC may play an important role in this process . Positive_regulation TNF CALM3 8546576 346329 Calcium and *regulate* lipopolysaccharide induced alveolar macrophage production of [tumor necrosis factor] and procoagulant activity . Positive_regulation TNF CALML3 11092689 754879 By contrast , and FFx + CLP *increased* [TNF-alpha] release 25 % and 100 % , respectively . Positive_regulation TNF CALML3 16192447 1500842 The GRP antagonist attenuated LPS- or *induced* [TNF-alpha] , IL-1beta , and nitric oxide release in cultured macrophages and decreased the mRNA levels of inducible nitric oxide synthase . Positive_regulation TNF CALML3 19828675 2187347 Additionally , PDTC and siRNA pretreatment inhibited the *induced* increase in renal [TNF-alpha] and IL-1beta concentration and NOS-2 mRNA abundance . Positive_regulation TNF CALML3 23524166 2777272 XBJ significantly reduced the mortality rate , anal temperature and expression of [TNF-a] , IL-1ß and IL-6 *induced* by . Positive_regulation TNF CAMK2B 10718374 676665 Inhibition of prior to adherence prevented ERK 1/2 activation and *attenuated* by up to 40 % , the [TNFalpha] response to subsequent LPS stimulation . Positive_regulation TNF CAMK4 15665723 1365618 Inhibition of *prevented* LPS induced ERK 1/2 , JNK/SAPK , NF-kappaB and AP-1 activation , and [TNF-alpha] production , but increased IL-10 production with or without PAF pretreatment . Positive_regulation TNF CAMK4 20954187 2382144 inhibition in MRL/lpr mice *resulted* in significant suppression of nephritis and skin disease , decreased expression of the costimulatory molecules CD86 and CD80 on B cells , and suppression of IFN? and [tumor necrosis factor] a production . Positive_regulation TNF CAMKK1 18270593 1871996 inhibition *attenuated* PMA dependent IL-10 production and enhanced [TNFalpha] production indicating a shift from type-II to classical monocyte activation . Positive_regulation TNF CAMP 16723446 1565401 *induced* HCEC migration ( n=5 ) and secretion of IL-8 , IL-6 , IL-1beta , and [TNF-alpha] ( 2- to 23-fold , n=4-7 ) . Positive_regulation TNF CAPN1 11288141 800368 Results of this study suggest [TNF-alpha] may *induce* caspase-3 activation but not activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation TNF CAPN1 16574073 1543470 Tumor necrosis factor ( [TNF-alpha] ) stimulation *induced* increased expression of , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation TNF CAPN1 19318376 2087125 gp91(phox)-NADPH oxidase mediated activation *induces* caspase-3 activation and [TNF-alpha] expression in cardiomyocytes during LPS stimulation . Positive_regulation TNF CAPN10 11288141 800369 Results of this study suggest [TNF-alpha] may *induce* caspase-3 activation but not activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation TNF CAPN10 16574073 1543471 Tumor necrosis factor ( [TNF-alpha] ) stimulation *induced* increased expression of , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation TNF CAPN11 11288141 800370 Results of this study suggest [TNF-alpha] may *induce* caspase-3 activation but not activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation TNF CAPN11 16574073 1543472 Tumor necrosis factor ( [TNF-alpha] ) stimulation *induced* increased expression of , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation TNF CAPN12 11288141 800367 Results of this study suggest [TNF-alpha] may *induce* caspase-3 activation but not activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation TNF CAPN12 16574073 1543469 Tumor necrosis factor ( [TNF-alpha] ) stimulation *induced* increased expression of , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation TNF CAPN13 11288141 800379 Results of this study suggest [TNF-alpha] may *induce* caspase-3 activation but not activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation TNF CAPN13 16574073 1543480 [Tumor necrosis factor] ( TNF-alpha ) stimulation *induced* increased expression of , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation TNF CAPN14 11288141 800380 Results of this study suggest [TNF-alpha] may *induce* caspase-3 activation but not activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation TNF CAPN14 16574073 1543481 [Tumor necrosis factor] ( TNF-alpha ) stimulation *induced* increased expression of , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation TNF CAPN15 11288141 800366 Results of this study suggest [TNF-alpha] may *induce* caspase-3 activation but not activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation TNF CAPN15 16574073 1543468 Tumor necrosis factor ( [TNF-alpha] ) stimulation *induced* increased expression of , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation TNF CAPN2 11288141 800371 Results of this study suggest [TNF-alpha] may *induce* caspase-3 activation but not activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation TNF CAPN2 16574073 1543473 Tumor necrosis factor ( [TNF-alpha] ) stimulation *induced* increased expression of , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation TNF CAPN3 11288141 800372 Results of this study suggest [TNF-alpha] may *induce* caspase-3 activation but not activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation TNF CAPN3 16574073 1543474 Tumor necrosis factor ( [TNF-alpha] ) stimulation *induced* increased expression of , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation TNF CAPN5 11288141 800373 Results of this study suggest [TNF-alpha] may *induce* caspase-3 activation but not activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation TNF CAPN5 16574073 1543475 Tumor necrosis factor ( [TNF-alpha] ) stimulation *induced* increased expression of , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation TNF CAPN6 11288141 800374 Results of this study suggest [TNF-alpha] may *induce* caspase-3 activation but not activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation TNF CAPN6 16574073 1543476 [Tumor necrosis factor] ( TNF-alpha ) stimulation *induced* increased expression of , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation TNF CAPN7 11288141 800375 Results of this study suggest [TNF-alpha] may *induce* caspase-3 activation but not activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation TNF CAPN7 16574073 1543477 [Tumor necrosis factor] ( TNF-alpha ) stimulation *induced* increased expression of , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation TNF CAPN8 11288141 800376 Results of this study suggest [TNF-alpha] may *induce* caspase-3 activation but not activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation TNF CAPN8 16574073 1543478 [Tumor necrosis factor] ( TNF-alpha ) stimulation *induced* increased expression of , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation TNF CAPN9 11288141 800377 Results of this study suggest [TNF-alpha] may *induce* caspase-3 activation but not activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation TNF CAPN9 16574073 1543479 [Tumor necrosis factor] ( TNF-alpha ) stimulation *induced* increased expression of , m-calpain , and MMP-3 in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation TNF CAPNS1 19318376 2087126 gp91(phox)-NADPH oxidase mediated activation *induces* caspase-3 activation and [TNF-alpha] expression in cardiomyocytes during LPS stimulation . Positive_regulation TNF CARD8 22711073 2621317 *Role* of NLRP3 and in the regulation of [TNF-a] induced IL-1ß release in vascular smooth muscle cells . Positive_regulation TNF CARD9 19124758 2019591 However , priming of bone marrow derived macrophages with GM-CSF or IFN-gamma permits *mediated* [TNF-alpha] induction . Positive_regulation TNF CARHSP1 21078874 2371616 Transfecting into RAW264.7 cells *results* in an increase in [TNF-a] 3'UTR luciferase expression in resting cells and CARHSP1 knockdown LPS stimulated cells . Positive_regulation TNF CASP1 10425195 632740 [TNF] *induces* activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation TNF CASP1 11562122 862738 Although cell killing and induction were higher in the more hypertrophic cells , [TNF-alpha] *induced* apoptosis in both hypertrophic and non-hypertrophic chondrocyte populations . Positive_regulation TNF CASP1 11847111 912603 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Positive_regulation TNF CASP1 12036088 949091 [TNF] *increases* proapoptotic p53 levels and activities in fetal membranes . Positive_regulation TNF CASP1 16492401 1567742 [TNF-alpha] *induced* a gradual increase in and -8 mRNA levels that was not seen with IL-1beta . Positive_regulation TNF CASP1 16571730 1562400 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP1 16924232 1692182 [TNF] *induced* the expression of NF-kappaB regulated gene products cyclin D1 , c-Myc , matrix metalloproteinase-9 , survivin , X-linked inhibitor-of-apoptosis protein ( IAP ) , IAP1 , Bcl-x ( L ) , A1/Bfl-1 and Fas associated death domain protein-like protein in wild-type MEF but not in PKR-/- cells . Positive_regulation TNF CASP1 16979778 1628112 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP1 17551224 1752637 However , leptin treatment increased monocyte/macrophages production of IL-1beta as well as [TNF-alpha] , and *induced* the mRNA expression of , which is shown to mediate the conversion of latent pro-IL-1beta and pro-IL-18 to active forms . Positive_regulation TNF CASP1 17599041 1848503 Consistent with the results using c-Flip ( -/- ) MEFs , we found that [TNFalpha] stimulation *induced* dependent prolonged JNK activation and ROS accumulation , followed by apoptotic and necrotic cell death in various tumor cells . Positive_regulation TNF CASP1 18023359 1832140 Stimulation with IL-10 did not alter caspase activities , while co-treatment with IL-10 and TNF-alpha inhibited [TNF-alpha] *induced* activities and significantly ( p > 0.004 ) impaired bax/bcl-2 ratio . Positive_regulation TNF CASP1 18398369 1893718 Ischemia induced increased expressions of [TNF-alpha] ( P < or= 0.012 ) , IL-1beta ( P < or= 0.017 ) , ICAM-1 ( P < or= 0.025 ) , and IL-6 ( P = 0.012 ) , and diabetes *induced* increased expression of ( P < or= 0.046 ) , VCAM-1 ( P < or= 0.027 ) , ICAM-1 ( P < or= 0.016 ) , IL-1beta ( P = 0.016 ) , and IL-6 ( P = 0.041 ) . Positive_regulation TNF CASP1 21039733 2344305 Here , we demonstrate that in human NK cells activity is *required* for the upregulation of select activation markers and IFN-? and [TNF] production , but not for cytotoxicity . Positive_regulation TNF CASP1 21184820 2396751 Additionally , IHT inhibited the production of interleukin (IL)-6 , IL-8 , and [TNF-a] , as well as the *activation* of nuclear factor-?B and in PMACI stimulated HMC-1 . Positive_regulation TNF CASP1 21893119 2506425 Conversely , *activation* of by exogenous [TNF-a] required IL-13 , TWEAK , and Fn14 . Positive_regulation TNF CASP1 24283717 2916691 In parallel , NMDA triggered the expression of NOD-like receptor protein ( NLRP3 ) , *activation* of , and release of IL-1ß and [TNF-a] in primary WT but not TKO Müller cultures . Positive_regulation TNF CASP1 9726961 529846 Instead , [tumor necrosis factor] *induced* the translocation of to the nucleus where it was proteolytically activated , releasing the intact prodomain . Positive_regulation TNF CASP1 9769910 538768 The pathways leading to apoptosis following treatment with TNF + CHX and TNF + cer are different since only [TNF] + CHX is *blocked* by the inhibitors crmA protein or the peptide zVAD.fmk while only TNF + cer is blocked by the anti apoptotic proteins Bcl-2 , Bcl-XL or Al . Positive_regulation TNF CASP10 10425195 632741 [TNF] *induces* activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation TNF CASP10 11847111 912604 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Positive_regulation TNF CASP10 12036088 949092 [TNF] *increases* proapoptotic p53 levels and activities in fetal membranes . Positive_regulation TNF CASP10 16571730 1562401 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP10 16979778 1628113 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP10 17599041 1848504 Consistent with the results using c-Flip ( -/- ) MEFs , we found that [TNFalpha] stimulation *induced* dependent prolonged JNK activation and ROS accumulation , followed by apoptotic and necrotic cell death in various tumor cells . Positive_regulation TNF CASP10 18023359 1832141 Stimulation with IL-10 did not alter caspase activities , while co-treatment with IL-10 and TNF-alpha inhibited [TNF-alpha] *induced* activities and significantly ( p > 0.004 ) impaired bax/bcl-2 ratio . Positive_regulation TNF CASP10 21039733 2344306 Here , we demonstrate that in human NK cells activity is *required* for the upregulation of select activation markers and IFN-? and [TNF] production , but not for cytotoxicity . Positive_regulation TNF CASP10 21893119 2506426 Conversely , *activation* of by exogenous [TNF-a] required IL-13 , TWEAK , and Fn14 . Positive_regulation TNF CASP10 9769910 538769 The pathways leading to apoptosis following treatment with TNF + CHX and TNF + cer are different since only TNF + CHX is *blocked* by the inhibitors crmA protein or the peptide zVAD.fmk while only [TNF] + cer is blocked by the anti apoptotic proteins Bcl-2 , Bcl-XL or Al . Positive_regulation TNF CASP12 10425195 632751 [TNF] *induces* activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation TNF CASP12 11847111 912614 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Positive_regulation TNF CASP12 12036088 949102 [TNF] *increases* proapoptotic p53 levels and activities in fetal membranes . Positive_regulation TNF CASP12 16571730 1562411 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP12 16979778 1628123 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP12 17599041 1848514 Consistent with the results using c-Flip ( -/- ) MEFs , we found that [TNFalpha] stimulation *induced* dependent prolonged JNK activation and ROS accumulation , followed by apoptotic and necrotic cell death in various tumor cells . Positive_regulation TNF CASP12 18023359 1832151 Stimulation with IL-10 did not alter caspase activities , while co-treatment with IL-10 and TNF-alpha inhibited [TNF-alpha] *induced* activities and significantly ( p > 0.004 ) impaired bax/bcl-2 ratio . Positive_regulation TNF CASP12 21039733 2344316 Here , we demonstrate that in human NK cells activity is *required* for the upregulation of select activation markers and IFN-? and [TNF] production , but not for cytotoxicity . Positive_regulation TNF CASP12 21893119 2506437 Conversely , *activation* of by exogenous [TNF-a] required IL-13 , TWEAK , and Fn14 . Positive_regulation TNF CASP12 9769910 538779 The pathways leading to apoptosis following treatment with TNF + CHX and TNF + cer are different since only TNF + CHX is *blocked* by the inhibitors crmA protein or the peptide zVAD.fmk while only [TNF] + cer is blocked by the anti apoptotic proteins Bcl-2 , Bcl-XL or Al . Positive_regulation TNF CASP14 10425195 632742 [TNF] *induces* activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation TNF CASP14 11847111 912605 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Positive_regulation TNF CASP14 12036088 949093 [TNF] *increases* proapoptotic p53 levels and activities in fetal membranes . Positive_regulation TNF CASP14 16571730 1562402 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP14 16979778 1628114 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP14 17599041 1848505 Consistent with the results using c-Flip ( -/- ) MEFs , we found that [TNFalpha] stimulation *induced* dependent prolonged JNK activation and ROS accumulation , followed by apoptotic and necrotic cell death in various tumor cells . Positive_regulation TNF CASP14 18023359 1832142 Stimulation with IL-10 did not alter caspase activities , while co-treatment with IL-10 and TNF-alpha inhibited [TNF-alpha] *induced* activities and significantly ( p > 0.004 ) impaired bax/bcl-2 ratio . Positive_regulation TNF CASP14 21039733 2344307 Here , we demonstrate that in human NK cells activity is *required* for the upregulation of select activation markers and IFN-? and [TNF] production , but not for cytotoxicity . Positive_regulation TNF CASP14 21893119 2506427 Conversely , *activation* of by exogenous [TNF-a] required IL-13 , TWEAK , and Fn14 . Positive_regulation TNF CASP14 9769910 538770 The pathways leading to apoptosis following treatment with TNF + CHX and TNF + cer are different since only [TNF] + CHX is *blocked* by the inhibitors crmA protein or the peptide zVAD.fmk while only TNF + cer is blocked by the anti apoptotic proteins Bcl-2 , Bcl-XL or Al . Positive_regulation TNF CASP16 10425195 632752 [TNF] *induces* activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation TNF CASP16 11847111 912615 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Positive_regulation TNF CASP16 12036088 949103 [TNF] *increases* proapoptotic p53 levels and activities in fetal membranes . Positive_regulation TNF CASP16 16571730 1562412 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP16 16979778 1628124 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP16 17599041 1848515 Consistent with the results using c-Flip ( -/- ) MEFs , we found that [TNFalpha] stimulation *induced* dependent prolonged JNK activation and ROS accumulation , followed by apoptotic and necrotic cell death in various tumor cells . Positive_regulation TNF CASP16 18023359 1832152 Stimulation with IL-10 did not alter caspase activities , while co-treatment with IL-10 and TNF-alpha inhibited [TNF-alpha] *induced* activities and significantly ( p > 0.004 ) impaired bax/bcl-2 ratio . Positive_regulation TNF CASP16 21039733 2344317 Here , we demonstrate that in human NK cells activity is *required* for the upregulation of select activation markers and IFN-? and [TNF] production , but not for cytotoxicity . Positive_regulation TNF CASP16 21893119 2506438 Conversely , *activation* of by exogenous [TNF-a] required IL-13 , TWEAK , and Fn14 . Positive_regulation TNF CASP16 9769910 538780 The pathways leading to apoptosis following treatment with TNF + CHX and TNF + cer are different since only [TNF] + CHX is *blocked* by the inhibitors crmA protein or the peptide zVAD.fmk while only TNF + cer is blocked by the anti apoptotic proteins Bcl-2 , Bcl-XL or Al . Positive_regulation TNF CASP2 10425195 632743 [TNF] *induces* activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation TNF CASP2 11847111 912606 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Positive_regulation TNF CASP2 12036088 949094 [TNF] *increases* proapoptotic p53 levels and activities in fetal membranes . Positive_regulation TNF CASP2 16012953 1431721 Pharmacological , genetic , or small interfering RNA mediated inhibition of *attenuated* [tumor necrosis factor] alpha mediated mitochondrial dysfunction , downstream caspase activation , and hepatocyte apoptosis . Positive_regulation TNF CASP2 16571730 1562403 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP2 16979778 1628115 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP2 17599041 1848506 Consistent with the results using c-Flip ( -/- ) MEFs , we found that [TNFalpha] stimulation *induced* dependent prolonged JNK activation and ROS accumulation , followed by apoptotic and necrotic cell death in various tumor cells . Positive_regulation TNF CASP2 18023359 1832143 Stimulation with IL-10 did not alter caspase activities , while co-treatment with IL-10 and TNF-alpha inhibited [TNF-alpha] *induced* activities and significantly ( p > 0.004 ) impaired bax/bcl-2 ratio . Positive_regulation TNF CASP2 21039733 2344308 Here , we demonstrate that in human NK cells activity is *required* for the upregulation of select activation markers and IFN-? and [TNF] production , but not for cytotoxicity . Positive_regulation TNF CASP2 21893119 2506428 Conversely , *activation* of by exogenous [TNF-a] required IL-13 , TWEAK , and Fn14 . Positive_regulation TNF CASP2 9769910 538771 The pathways leading to apoptosis following treatment with TNF + CHX and TNF + cer are different since only TNF + CHX is *blocked* by the inhibitors crmA protein or the peptide zVAD.fmk while only [TNF] + cer is blocked by the anti apoptotic proteins Bcl-2 , Bcl-XL or Al . Positive_regulation TNF CASP3 10425195 632744 [TNF] *induces* activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation TNF CASP3 10723061 579414 Interferon-gamma augmented the *activation* of by [TNF-alpha] in HOG cells and O2A ( + ) oligodendrocyte precursor cells but had no effect on mature oligodendrocytes . Positive_regulation TNF CASP3 10764146 683987 Both GM-CSF and [TNF] induced caspase 3-like activity in this cell line though the time course was distinct between two cytokines , and combined stimulation of cells with GM-CSF plus TNF *induced* additive or synergistic activation of activity . Positive_regulation TNF CASP3 10854232 704236 Cytochrome c-dependent *activation* of by [tumor necrosis factor] requires induction of the mitochondrial permeability transition . Positive_regulation TNF CASP3 11005210 735062 However , XIAP expression was down-regulated by [TNF-alpha] , which *induced* apoptotic cell death of HSG cells with an increase in activity . Positive_regulation TNF CASP3 11288141 800378 Results of this study suggest [TNF-alpha] may *induce* activation but not calpain activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis . Positive_regulation TNF CASP3 11847111 912607 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Positive_regulation TNF CASP3 12036088 949095 [TNF] *increases* proapoptotic p53 levels and activities in fetal membranes . Positive_regulation TNF CASP3 12568116 1029444 [TNF] + IFNgamma did not *induce* activation in primary mouse islets . Positive_regulation TNF CASP3 15499968 1326829 The aim of current study was to investigate the effect of PKCalpha activation by FB1 on NF-kappaB activation and subsequently on [TNFalpha] gene expression and *induction* in LLC-PK1 cells . Positive_regulation TNF CASP3 15733908 1378004 A similar DNA fragmentation and activation was *induced* by [TNF-alpha] , but without Bcl-xS/Bcl-xL increase , cytochrome c release or caspase 9 activation . Positive_regulation TNF CASP3 16571730 1562404 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP3 16801388 1579401 When ATM or ATR is down expressed by using the small interfering RNA technique , the [TNF-alpha-] or tCdc6 induced *activation* of activities is suppressed in the cells . Positive_regulation TNF CASP3 16979778 1628116 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP3 17302993 1699016 The hypoxia-inducible factor-1alpha ( HIF-1alpha ) , *activation* of , and [TNF-alpha] mRNA transcription in ischemic regions were detected by immunoblotting and RT-PCR , respectively . Positive_regulation TNF CASP3 17599041 1848507 Consistent with the results using c-Flip ( -/- ) MEFs , we found that [TNFalpha] stimulation *induced* dependent prolonged JNK activation and ROS accumulation , followed by apoptotic and necrotic cell death in various tumor cells . Positive_regulation TNF CASP3 18023359 1832144 Stimulation with IL-10 did not alter caspase activities , while co-treatment with IL-10 and TNF-alpha inhibited [TNF-alpha] *induced* activities and significantly ( p > 0.004 ) impaired bax/bcl-2 ratio . Positive_regulation TNF CASP3 18182160 1856528 Western blot analysis revealed that [TNF-alpha] *induced* activation of and Mst1 in a time- and dose dependent manner . Positive_regulation TNF CASP3 18270473 1871986 The elevation of serum [tumor necrosis factor-alpha] and *activation* of were observed in the GalN/LPS group , which was attenuated by gomisin A . Positive_regulation TNF CASP3 18305255 1873629 The activated microglia became neurotoxic , killing naive neurons through an apoptotic mechanism that was mediated by [tumor necrosis factor-alpha (TNF-alpha)] , and *involved* activation of both caspase-8 and . Positive_regulation TNF CASP3 18840762 1994070 These results suggest that [TNF-alpha/IFN-gamma] and ANG II induce muscle protein degradation by a common signaling pathway , which is attenuated by HMB , and that this *involves* the initial activation of and -8 , followed by autophosphorylation and activation of PKR , which then leads to increased ROS formation via activation of p38 MAPK . Positive_regulation TNF CASP3 19555759 2117078 By using knock-out mice for TNF-alpha receptor 1 , we show that the *activation* of both and -8 by [TNF-alpha] is mediated by TNF-alpha receptor 1 . Positive_regulation TNF CASP3 19996917 2185060 Myocardial IL-1beta and [TNF-alpha] production and *activation* of were significantly decreased after infusion of both cell groups . Positive_regulation TNF CASP3 20713143 2335599 Elevation of [TNF-a] level and *activation* of , HIF-1a were observed in the D-GalN/LPS group , which was attenuated by OC . Positive_regulation TNF CASP3 21039733 2344309 Here , we demonstrate that in human NK cells activity is *required* for the upregulation of select activation markers and IFN-? and [TNF] production , but not for cytotoxicity . Positive_regulation TNF CASP3 21893119 2506429 Conversely , *activation* of by exogenous [TNF-a] required IL-13 , TWEAK , and Fn14 . Positive_regulation TNF CASP3 22579834 2614254 In the meanwhile , the microbubbles attenuated the production of inducible nitric oxide synthase , nitric oxide and [tumor necrosis factor-alpha] , as well as the *activation* of in insulted side of brain in neonatal rats . Positive_regulation TNF CASP3 23688976 2785588 a-Toxin induced apoptosis of HUV-EC-C cells in a dose- and time dependent manner and caused significantly enhanced expression of [TNF-a] and the *activation* of both and caspase-8 . Positive_regulation TNF CASP3 23799615 2807960 In addition , SEB and a-toxin were able to induce the expression of [TNF-a] and the *activation* of and -8 in the ECV304 cells . Positive_regulation TNF CASP3 9769910 538772 The pathways leading to apoptosis following treatment with TNF + CHX and TNF + cer are different since only [TNF] + CHX is *blocked* by the inhibitors crmA protein or the peptide zVAD.fmk while only TNF + cer is blocked by the anti apoptotic proteins Bcl-2 , Bcl-XL or Al . Positive_regulation TNF CASP4 10425195 632745 [TNF] *induces* activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation TNF CASP4 11847111 912608 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Positive_regulation TNF CASP4 12036088 949096 [TNF] *increases* proapoptotic p53 levels and activities in fetal membranes . Positive_regulation TNF CASP4 16571730 1562405 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP4 16979778 1628117 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP4 17599041 1848508 Consistent with the results using c-Flip ( -/- ) MEFs , we found that [TNFalpha] stimulation *induced* dependent prolonged JNK activation and ROS accumulation , followed by apoptotic and necrotic cell death in various tumor cells . Positive_regulation TNF CASP4 18023359 1832145 Stimulation with IL-10 did not alter caspase activities , while co-treatment with IL-10 and TNF-alpha inhibited [TNF-alpha] *induced* activities and significantly ( p > 0.004 ) impaired bax/bcl-2 ratio . Positive_regulation TNF CASP4 21039733 2344310 Here , we demonstrate that in human NK cells activity is *required* for the upregulation of select activation markers and IFN-? and [TNF] production , but not for cytotoxicity . Positive_regulation TNF CASP4 21893119 2506430 Conversely , *activation* of by exogenous [TNF-a] required IL-13 , TWEAK , and Fn14 . Positive_regulation TNF CASP4 9769910 538773 The pathways leading to apoptosis following treatment with TNF + CHX and TNF + cer are different since only TNF + CHX is *blocked* by the inhibitors crmA protein or the peptide zVAD.fmk while only [TNF] + cer is blocked by the anti apoptotic proteins Bcl-2 , Bcl-XL or Al . Positive_regulation TNF CASP5 10425195 632746 [TNF] *induces* activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation TNF CASP5 11847111 912609 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Positive_regulation TNF CASP5 12036088 949097 [TNF] *increases* proapoptotic p53 levels and activities in fetal membranes . Positive_regulation TNF CASP5 16571730 1562406 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP5 16979778 1628118 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP5 17599041 1848509 Consistent with the results using c-Flip ( -/- ) MEFs , we found that [TNFalpha] stimulation *induced* dependent prolonged JNK activation and ROS accumulation , followed by apoptotic and necrotic cell death in various tumor cells . Positive_regulation TNF CASP5 17725714 1789913 gene expression was *induced* by [TNF-alpha] , which was inhibited by the small hairpin RNA mediated down-regulation of p73 . Positive_regulation TNF CASP5 18023359 1832146 Stimulation with IL-10 did not alter caspase activities , while co-treatment with IL-10 and TNF-alpha inhibited [TNF-alpha] *induced* activities and significantly ( p > 0.004 ) impaired bax/bcl-2 ratio . Positive_regulation TNF CASP5 21039733 2344311 Here , we demonstrate that in human NK cells activity is *required* for the upregulation of select activation markers and IFN-? and [TNF] production , but not for cytotoxicity . Positive_regulation TNF CASP5 21893119 2506431 Conversely , *activation* of by exogenous [TNF-a] required IL-13 , TWEAK , and Fn14 . Positive_regulation TNF CASP5 9769910 538774 The pathways leading to apoptosis following treatment with TNF + CHX and TNF + cer are different since only [TNF] + CHX is *blocked* by the inhibitors crmA protein or the peptide zVAD.fmk while only TNF + cer is blocked by the anti apoptotic proteins Bcl-2 , Bcl-XL or Al . Positive_regulation TNF CASP6 10425195 632747 [TNF] *induces* activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation TNF CASP6 11847111 912610 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Positive_regulation TNF CASP6 12036088 949098 [TNF] *increases* proapoptotic p53 levels and activities in fetal membranes . Positive_regulation TNF CASP6 16571730 1562407 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP6 16979778 1628119 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP6 17599041 1848510 Consistent with the results using c-Flip ( -/- ) MEFs , we found that [TNFalpha] stimulation *induced* dependent prolonged JNK activation and ROS accumulation , followed by apoptotic and necrotic cell death in various tumor cells . Positive_regulation TNF CASP6 18023359 1832147 Stimulation with IL-10 did not alter caspase activities , while co-treatment with IL-10 and TNF-alpha inhibited [TNF-alpha] *induced* activities and significantly ( p > 0.004 ) impaired bax/bcl-2 ratio . Positive_regulation TNF CASP6 21039733 2344312 Here , we demonstrate that in human NK cells activity is *required* for the upregulation of select activation markers and IFN-? and [TNF] production , but not for cytotoxicity . Positive_regulation TNF CASP6 21893119 2506432 Conversely , *activation* of by exogenous [TNF-a] required IL-13 , TWEAK , and Fn14 . Positive_regulation TNF CASP6 24531553 2918964 Recombinant ( rCASP6 ) *induced* marked [TNF-a] release in microglial cultures , and most microglia within the spinal cord expressed Tnfa . Positive_regulation TNF CASP6 24531553 2918966 Together , these data suggest that released from axonal terminals *regulates* microglial [TNF-a] secretion , synaptic plasticity , and inflammatory pain . Positive_regulation TNF CASP6 9769910 538775 The pathways leading to apoptosis following treatment with TNF + CHX and TNF + cer are different since only TNF + CHX is *blocked* by the inhibitors crmA protein or the peptide zVAD.fmk while only [TNF] + cer is blocked by the anti apoptotic proteins Bcl-2 , Bcl-XL or Al . Positive_regulation TNF CASP7 10425195 632748 [TNF] *induces* activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation TNF CASP7 11112424 757615 Overexpression of PKC eta delayed the *activation* of by both [TNF] and the combination of BIM and TNF . Positive_regulation TNF CASP7 11847111 912611 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Positive_regulation TNF CASP7 12036088 949099 [TNF] *increases* proapoptotic p53 levels and activities in fetal membranes . Positive_regulation TNF CASP7 16571730 1562408 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP7 16979778 1628120 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP7 17599041 1848511 Consistent with the results using c-Flip ( -/- ) MEFs , we found that [TNFalpha] stimulation *induced* dependent prolonged JNK activation and ROS accumulation , followed by apoptotic and necrotic cell death in various tumor cells . Positive_regulation TNF CASP7 18023359 1832148 Stimulation with IL-10 did not alter caspase activities , while co-treatment with IL-10 and TNF-alpha inhibited [TNF-alpha] *induced* activities and significantly ( p > 0.004 ) impaired bax/bcl-2 ratio . Positive_regulation TNF CASP7 21039733 2344313 Here , we demonstrate that in human NK cells activity is *required* for the upregulation of select activation markers and IFN-? and [TNF] production , but not for cytotoxicity . Positive_regulation TNF CASP7 21893119 2506433 Conversely , *activation* of by exogenous [TNF-a] required IL-13 , TWEAK , and Fn14 . Positive_regulation TNF CASP7 9769910 538776 The pathways leading to apoptosis following treatment with TNF + CHX and TNF + cer are different since only [TNF] + CHX is *blocked* by the inhibitors crmA protein or the peptide zVAD.fmk while only TNF + cer is blocked by the anti apoptotic proteins Bcl-2 , Bcl-XL or Al . Positive_regulation TNF CASP8 10425195 632749 [TNF] *induces* activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation TNF CASP8 11112424 757616 Overexpression of PKC eta delayed the *activation* of and -7 by both [TNF] and the combination of BIM and TNF . Positive_regulation TNF CASP8 11847111 912612 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Positive_regulation TNF CASP8 12036088 949100 [TNF] *increases* proapoptotic p53 levels and activities in fetal membranes . Positive_regulation TNF CASP8 12115505 964131 Therefore , Kupffer cells execute their anti-tumor effect via increasing the production of NO , [TNFalpha] and IFNgamma and these cytotoxic molecules inhibit the growth of tumor by damaging cellular DNA and *inducing* apoptosis that was featured by downregulation of Bcl-2 but upregulation of . Positive_regulation TNF CASP8 12828936 1105042 Although caspase-8 is known to be involved in death-receptor dependent apoptosis , measurable activity or even RGC death could be *induced* by neither [tumor necrosis factor-alpha] nor Fas ligand injections into unlesioned eyes . Positive_regulation TNF CASP8 12959751 1138348 Virally encoded genes inhibit the *activation* of by the [TNF] receptor and Fas ; Positive_regulation TNF CASP8 14696112 1195287 In addition , 2-methoxyestradiol treatment caused upregulation of death receptor ligands FasL and [TNFalpha] and *induced* activation . Positive_regulation TNF CASP8 15791480 1386601 As mitochondria related activation of this caspase cascade , through e.g . APAF-1 , could not be proven in dystrophin-deficient muscle , this study searches for other prospective candidates that may directly trigger apoptotic cell degradation by mitochondria independent pathways involving the interaction of [tumour necrosis factor-alpha (TNF-alpha)] and TRAIL with death receptors and subsequent *activation* of . Positive_regulation TNF CASP8 16492401 1567743 [TNF-alpha] *induced* a gradual increase in mRNA levels that was not seen with IL-1beta . Positive_regulation TNF CASP8 16571730 1562409 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP8 16715133 1638316 Taken together , these data suggest that upregulation of TMS1/ASC by [TNFalpha] and subsequent *activation* of could function to amplify the apoptotic signal induced by death receptors in some cell types , including breast epithelial cells . Positive_regulation TNF CASP8 16979778 1628121 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP8 17599041 1848512 Consistent with the results using c-Flip ( -/- ) MEFs , we found that [TNFalpha] stimulation *induced* dependent prolonged JNK activation and ROS accumulation , followed by apoptotic and necrotic cell death in various tumor cells . Positive_regulation TNF CASP8 17673311 1816355 As ( 2 ) O ( 3 ) plus [TNFalpha] increases TNF receptor type 1 (TNF-R1) expression , decreases c-FLIP ( L ) expression , and causes caspase-8 and Bid activation , and apoptosis is *reduced* by anti-TNF-R1 neutralizing antibody and inhibitor . Positive_regulation TNF CASP8 18023359 1832149 Stimulation with IL-10 did not alter caspase activities , while co-treatment with IL-10 and TNF-alpha inhibited [TNF-alpha] *induced* activities and significantly ( p > 0.004 ) impaired bax/bcl-2 ratio . Positive_regulation TNF CASP8 18305255 1873630 The activated microglia became neurotoxic , killing naive neurons through an apoptotic mechanism that was mediated by [tumor necrosis factor-alpha (TNF-alpha)] , and *involved* activation of both and caspase-3 . Positive_regulation TNF CASP8 18840762 1994071 These results suggest that [TNF-alpha/IFN-gamma] and ANG II induce muscle protein degradation by a common signaling pathway , which is attenuated by HMB , and that this *involves* the initial activation of , followed by autophosphorylation and activation of PKR , which then leads to increased ROS formation via activation of p38 MAPK . Positive_regulation TNF CASP8 19555759 2117079 By using knock-out mice for TNF-alpha receptor 1 , we show that the *activation* of both by [TNF-alpha] is mediated by TNF-alpha receptor 1 . Positive_regulation TNF CASP8 19813266 2195927 Genistein triggered the receptor mediated apoptotic pathway through upregulation of [TNF-alpha] , FasL , TRADD , and FADD and *activation* of . Positive_regulation TNF CASP8 20089176 2206061 In conclusion , our results have demonstrated that ECP increased [TNF-alpha] production in BEAS-2B cells and *triggered* apoptosis by activation through mitochondria independent pathway . Positive_regulation TNF CASP8 20299954 2273028 Furthermore , expression in primary CD4 T cells *results* in increased production of interleukin (IL)-2 , IL-15 and [tumor necrosis factor (TNF)] , as well as IL-1RA ; Positive_regulation TNF CASP8 21039733 2344314 Here , we demonstrate that in human NK cells activity is *required* for the upregulation of select activation markers and IFN-? and [TNF] production , but not for cytotoxicity . Positive_regulation TNF CASP8 21893119 2506434 Conversely , *activation* of by exogenous [TNF-a] required IL-13 , TWEAK , and Fn14 . Positive_regulation TNF CASP8 22095280 2574718 In mouse embryonic fibroblasts , neither caspase-8 nor cellular is *necessary* for [TNF] to activate NF-?B , but caspase-8 is required for TNF to cause cell death , and induction of FLIP by NF-?B is required to prevent it . Positive_regulation TNF CASP8 22095280 2574719 These results show that in MEFs , is *necessary* for [TNF-] and FasL induced death , and FLIP is needed to prevent it , but neither caspase-8 nor FLIP is required for TNF to activate NF-?B . Positive_regulation TNF CASP8 23688976 2785589 a-Toxin induced apoptosis of HUV-EC-C cells in a dose- and time dependent manner and caused significantly enhanced expression of [TNF-a] and the *activation* of both caspase-3 and . Positive_regulation TNF CASP8 23759588 2812171 Subsequent synthesis of TNF-a in the cells under the action of binase triggers extrinsic apoptotic pathway through the binding of [TNF] with cell-death receptors and *activation* of . Positive_regulation TNF CASP8 9769910 538777 The pathways leading to apoptosis following treatment with TNF + CHX and TNF + cer are different since only TNF + CHX is *blocked* by the inhibitors crmA protein or the peptide zVAD.fmk while only [TNF] + cer is blocked by the anti apoptotic proteins Bcl-2 , Bcl-XL or Al . Positive_regulation TNF CASP9 10425195 632750 [TNF] *induces* activity in both settings , and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis . Positive_regulation TNF CASP9 11847111 912613 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Positive_regulation TNF CASP9 12036088 949101 [TNF] *increases* proapoptotic p53 levels and activities in fetal membranes . Positive_regulation TNF CASP9 16571730 1562410 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP9 16979778 1628122 In the absence of jnk2 , the *dependent* , [TNF] death pathway was blocked , as reflected by the failure of caspase-3 and -7 and poly ( ADP-ribose ) polymerase cleavage to occur . Positive_regulation TNF CASP9 17599041 1848513 Consistent with the results using c-Flip ( -/- ) MEFs , we found that [TNFalpha] stimulation *induced* dependent prolonged JNK activation and ROS accumulation , followed by apoptotic and necrotic cell death in various tumor cells . Positive_regulation TNF CASP9 18023359 1832150 Stimulation with IL-10 did not alter caspase activities , while co-treatment with IL-10 and TNF-alpha inhibited [TNF-alpha] *induced* activities and significantly ( p > 0.004 ) impaired bax/bcl-2 ratio . Positive_regulation TNF CASP9 21039733 2344315 Here , we demonstrate that in human NK cells activity is *required* for the upregulation of select activation markers and IFN-? and [TNF] production , but not for cytotoxicity . Positive_regulation TNF CASP9 21893119 2506435 Conversely , *activation* of by exogenous [TNF-a] required IL-13 , TWEAK , and Fn14 . Positive_regulation TNF CASP9 9769910 538778 The pathways leading to apoptosis following treatment with TNF + CHX and TNF + cer are different since only [TNF] + CHX is *blocked* by the inhibitors crmA protein or the peptide zVAD.fmk while only TNF + cer is blocked by the anti apoptotic proteins Bcl-2 , Bcl-XL or Al . Positive_regulation TNF CAST 15248852 1271245 The NF-kappaB inhibitors , 1 ( 10 microm ) , pentoxifylline ( 0.5 mm ) , pyrrolidine dithiocarbamate ( PDTC , 10 microm ) or gliotoxin ( 1 pg/mL ) *reduced* the generation of GM-CSF , [TNF-alpha] and IL-8 in parallel with their inhibition of NF-kappaB . Positive_regulation TNF CAT 18761070 1975444 Pretreatment with CGX significantly restored the reduction of activity and glutathione ( GSH ) content , but not superoxide dismutase (SOD) activity , and it *inhibited* the CCl ( 4 ) -induced high expression of iNOS and [TNF-alpha] in hepatic tissue . Positive_regulation TNF CAT 20479003 2288591 ClC-3 expression induced ICl ( swell ) in ClC-3 null cells in the absence of swelling or [TNF-alpha] , and this effect was also *blocked* by . Positive_regulation TNF CAT 7755631 307417 Transient overexpression of does not *inhibit* [TNF-] or PMA induced NF-kappa B activation . Positive_regulation TNF CAT 7755631 307420 Overexpression of , however , did not *block* [TNF-] or PMA induced NF-kappa B activation . Positive_regulation TNF CAV1 18803934 1965115 The *role* of fatty acids and in [tumor necrosis factor] alpha induced endothelial cell activation . Positive_regulation TNF CAV1 22241747 2629508 overexpression significantly *increased* Orai1 expression and SOCE , especially in the presence of [TNF-a] . Positive_regulation TNF CBL 10544191 564004 It thus appears that inversely *regulates* the expression of EGF and [TNF-alpha] genes in the CNS of TGX rats . Positive_regulation TNF CCL1 15378023 1324041 Neutralizing antibodies to *led* to reduced secretion of interferon-gamma and [tumor necrosis factor-alpha] as well as to reduced proliferation rates in transformed T cells . Positive_regulation TNF CCL1 19302817 2064269 Using the AhR antagonist alpha-napthtoflavone , the translational inhibitor cycloheximide and anti-tumor necrosis factor alpha (TNFalpha) neutralizing antibodies , we demonstrated that Lp(a) mediated mRNA induction of occurs in an AhR independent manner and *requires* de novo protein synthesis of [TNFalpha] . Positive_regulation TNF CCL11 11919075 926001 was *induced* by [tumor necrosis factor (TNF)-alpha] or interleukin (IL)-4 and was drastically increased by their combination . Positive_regulation TNF CCL13 10934112 720413 In support of our in situ findings demonstrating MCP-4 expression in epithelial cells and mononuclear cells in vivo , we have found that expression can be *induced* in these cells in vitro by [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) . Positive_regulation TNF CCL15 11888507 920042 also *induced* the transient expression of [TNF-alpha] , IL-8 , and MCP-1 within 15 min of the treatment of the THP-1 cells . Positive_regulation TNF CCL16 14525962 1185815 This ability to activate caspase-8 depends on their overexpression of [TNF-alpha] and Fas ligand *induced* by . Positive_regulation TNF CCL17 20022349 2241197 In this study , we investigated whether and CCL28 transcription in cultured keratinocytes is *induced* by [TNF-alpha] , IL-1beta , or IFN-gamma . Positive_regulation TNF CCL2 10331497 614622 Recombinant [tumor necrosis factor alpha (TNF-alpha)] *induced* a low level mRNA accumulation in neutrophils , and addition of anti-TNF-alpha IgG blocked 30-70 % of MCP-1 mRNA expression induced with PHA-sup . Positive_regulation TNF CCL2 10372996 622132 IL-1beta and [TNF-alpha] *induced* dose dependent increases in HRPE IL-8 and secretion with maximal stimulation observed at 2-5 ng/ml . IL-4 alone ( 100 ng/ml ) resulted in a slight increase of MCP-1 and IL-8 secretion . Positive_regulation TNF CCL2 10413089 630924 In human vascular endothelial cells , interleukin-1beta and [tumor necrosis factor-alpha] *induced* endogenous protein secretion , mRNA expression and promoter activity . Positive_regulation TNF CCL2 10542218 563702 These results show that the mechanisms of PDGF-BB and [TNF] *activation* of are distinct , although they both require the proximal regulatory region Sp1 binding site . Positive_regulation TNF CCL2 10559511 566630 Ang II and [TNF-alpha] *induced* the expression of IP-10 ( 1.5 and 3.4-fold ) and ( 2.4 and 4-fold ) in VSMC . Positive_regulation TNF CCL2 10602073 655224 [TNFalpha] *induced* EC expression and activity of and tissue factor and suppressed that of thrombomodulin on all substrates . Positive_regulation TNF CCL2 10690939 670590 Inhibitory effect of troglitazone on [tumor necrosis factor] alpha *induced* expression of in human mesangial cells . Positive_regulation TNF CCL2 10859471 704830 Regarding the biological functions of MCF-pl5-L other than MCA and chemotactic activity for alveolar macrophages , we found that MCF-pl5-L but not C5a and could prolong the life span of alveolar macrophages , probably by inhibiting apoptosis of macrophages , and *stimulate* the production of [TNF-alpha] from macrophages . Positive_regulation TNF CCL2 10889171 710418 IL-8 and secretion was rapidly *induced* by both IL-1beta and [tumor necrosis factor (TNF)-alpha] . Positive_regulation TNF CCL2 11016686 736504 In contrast , [TNF-alpha] *induced* a more rapid increase in production by SK than OK , peak production occurring after 24 and 72 h , respectively . Positive_regulation TNF CCL2 11583958 865922 could be *induced* by exogenous [tumor necrosis factor (TNF)-alpha] or by postischemic cardiac lymph containing TNF-alpha . Positive_regulation TNF CCL2 11591574 869487 In A549 cells , interleukin (IL)-1beta and [tumor necrosis factor (TNF)-alpha] *induced* endogenous protein secretion and messenger RNA expression . Positive_regulation TNF CCL2 11989790 936378 [TNF-alpha] *induced* a 95-fold increase in IL-8 and an 84-fold increase in levels , as compared to the controls . Positive_regulation TNF CCL2 12845752 779847 Interleukin-1 beta , [tumor necrosis factor-alpha] and lipopolysaccharide *induce* expression of in calf aortic smooth muscle cells . Positive_regulation TNF CCL2 12918065 1130777 Furthermore , additional results demonstrated that monocytic cell derived TNFalpha upregulated MCP-1 secretion from the tumor cells and that in turn *promoted* the secretion of [TNFalpha] from monocytic cells . Positive_regulation TNF CCL2 14682399 1179326 Using semi-quantitative RT-PCR and cell based ELISA , we demonstrated that [tumor necrosis factor-a] *induced* the expression of intercellular adhesion molecules-1 and E-selectin , as well as , in a time- and dose dependent manner in primary human coronary artery endothelial cell cultures . Positive_regulation TNF CCL2 14736953 1199604 These data demonstrate that while [TNF-alpha] *induced* production is mediated by the cooperative action of NF-kappa B and AP-1 in HGEC , dexamethasone represses TNF-alpha induced MCP-1 production via suppression of AP-1 binding activity . Positive_regulation TNF CCL2 14978197 1250874 Our results showed that [tumor necrosis factor (TNF)-alpha] *induced* a marked increase in production in dose- and time dependent manners . Positive_regulation TNF CCL2 15248214 1271193 CD14+ RA synovial cells stimulated with rsCD154 plus interferon-gamma (IFNgamma) *induced* significantly higher production of IL-6 , IL-8 , and by FLS compared with unstimulated CD14+ synovial cells , through [TNFalpha-] , IL-1alpha- , and IL-1beta mediated pathways . Positive_regulation TNF CCL2 15293554 1278959 The mRNA accumulation of IL-8 , , RANTES , and eotaxin , and activation of NF-kappaB were *induced* by [TNF-alpha] for 2 h ; Positive_regulation TNF CCL2 15562246 1380588 In contrast , [TNF-alpha] *induced* substantial increases in IL-6 , TNF-alpha , metallothionein , , and NGF mRNAs , the largest increase being with MCP-1 ( 14.5-fold ) . Positive_regulation TNF CCL2 15631627 1362353 Stimulation of HeLa and A549 cells with CpG-ODN induced secretion of and reduction of spontaneous and [tumor necrosis factor-alpha] *induced* apoptosis . Positive_regulation TNF CCL2 17424890 1723881 [TNF-alpha] *induces* transcription in NPFs . Positive_regulation TNF CCL2 17934338 1813454 *increased* the proliferation of FLS and the production of IL-15 , [TNF-alpha] , and IL-18 . Positive_regulation TNF CCL2 19107603 2047671 A recent report indicated that expression in human umbilical vein endothelial cells ( HUVECs ) is *induced* by the stimulation of [tumor necrosis factor (TNF)-alpha] via the c-Jun N-terminal kinases (JNK) pathway . Positive_regulation TNF CCL2 19458908 2115465 [TNF-alpha] *induced* , RANTES , and granzyme B production in cultured synovial cells from RA patients . Positive_regulation TNF CCL2 19747158 2163333 Expression of [TNF-alpha] was *detected* at 8 months of age , while IL-1 beta , IL-6 and at 10 months . Positive_regulation TNF CCL2 20069129 2177873 These results suggest that ticlopidine decreased [TNF-alpha] *induced* , IL-8 , and VCAM-1 levels in HUVECs , and monocyte adhesion . Positive_regulation TNF CCL2 20185130 2281453 We found that 5'-NIO inhibited [TNF-alpha] *induced* and IL-8 expression at the RNA and protein levels in HUVECs . Positive_regulation TNF CCL2 20406462 2255947 Moreover , the availability of p53 is apparently important for chemokine regulation , since [TNF-alpha] can *induce* only in human keratinocytes expressing the viral oncoprotein E7 , but not in HPV16 E6 positive cells , where p53 becomes degraded . Positive_regulation TNF CCL2 21544387 407752 We compared the in vitro effects of various cytokines on the expression of monocyte chemoattractant protein-1 ( MCP-1 ) in glioma cell lines and found that expression was highly *induced* by [tumor necrosis factor-alpha (TNF alpha)] and interleukin-1 beta . Positive_regulation TNF CCL2 21712071 2465765 Furthermore , increased in the DRG is *induced* by [TNF-a/TNFR1] and has no effect on the infiltration of macrophages into the DRG following L5 VR . Positive_regulation TNF CCL2 2182712 131884 [TNF] and LPS , unlike IL-6 , also *induced* gene expression . Positive_regulation TNF CCL2 22056354 2527957 Gene expression ( mRNA ) of MCP-1 , IL-1ß , IL-6 and [TNF-a] was *increased* in sections 2 and 3 starting at week 12 ( P < 0.05 ) , with further increases in , IL-1ß and IL-6 at 16 weeks ( P < 0.05 ) . Positive_regulation TNF CCL2 23803215 2808016 After 48h incubation , the expression of and FN *increased* significantly in TNF-a group ( P < 0.01 ) , which was lowered by exendin-4 in [TNF-a+E1,TNF-a+E5] and TNF-a+E10 groups ( P < 0.05 ) . Positive_regulation TNF CCL2 24028188 2842176 We sought to determine the mechanism by which [TNF-a] *induces* expression and secretion of from peripheral nerve microvascular endoneurial endothelial cells ( PNMECs ) . Positive_regulation TNF CCL2 24719782 2932012 [TNF] *induced* , CCL7 , and CXCL1 in preadipocytes but had no response in adipocytes . Positive_regulation TNF CCL2 24777714 2950241 Furthermore , expressions of [tumor necrosis factor (TNF)-a] and monocyte chemoattractant protein (MCP)-1 messenger ( m ) RNA in U87 and C6 cells were detected by an RT-PCR , and TNF-a and *induced* iNOS protein expression in time- and concentration dependent manners . Positive_regulation TNF CCL2 24826069 2937674 Retinal neuronal induced by AGEs *stimulates* [TNF-a] expression in rat microglia via p38 , ERK , and NF-?B pathways . Positive_regulation TNF CCL2 24826069 2937676 The levels of TNF-a mRNA and soluble [TNF-a] produced by the microglia in *response* to advanced glycation end product (AGE) induced retinal neuronal were measured with real-time PCR and enzyme linked immunosorbent assay ( ELISA ) . Positive_regulation TNF CCL2 7642742 318055 Lipopolysaccharide (LPS) , interleukin (IL)-1 beta and [tumor necrosis factor (TNF)-alpha] *induced* secretion by astrocytes , but not microglia . Positive_regulation TNF CCL2 7942160 276334 At the mRNA level , IL-1 beta and [TNF-alpha] strongly *induced* expression ; Positive_regulation TNF CCL2 8424834 210926 Use of cycloheximide and actinomycin D confirmed that [TNF alpha] was *inducing* expression at both the transcriptional and translational levels . Positive_regulation TNF CCL2 8832978 385878 Our data suggest that [TNF-alpha] *induces* expression of proinflammatory cytokines such as IL-8 and through generation of reactive oxygen intermediates and subsequent activation of NF-kappa B in human synovial cells , and the antioxidants may inhibit , at least in part , the activation of NF-kappa B by TNF-alpha . Positive_regulation TNF CCL2 9024159 413321 Both ischemic ( but not preischemic ) cardiac lymph and human recombinant [TNF-alpha] *induced* in CJVECs . Positive_regulation TNF CCL2 9130630 426884 Eosinophils generated immunoreactive in response to such diverse stimuli as C5a , formyl-methionyl-leucyl-phenylalanine ( FMLP ) and ionomycin , but MCP-1 production was not *induced* by interleukin (IL)-1 or [tumor necrosis factor-alpha] . Positive_regulation TNF CCL2 9176445 433745 moreover , both interleukin-1 alpha and [tumor necrosis factor-alpha] *induced* higher levels of . Positive_regulation TNF CCL2 9407069 470803 While [TNFalpha] *induced* both RANTES and , H2O2 induced only MCP-1 . Positive_regulation TNF CCL2 9610617 508785 [TNF-alpha] and LPS also *induced* and ICAM-1 gene expression . Positive_regulation TNF CCL2 9657919 516877 IL-1beta and [TNF-alpha] synergistically *induced* IL-6 and GM-CSF and additively induced IL-8 and production , while IL-2 , IL-10 , IFN-alpha , and IFN-gamma had little or no additional effects . Positive_regulation TNF CCL2 9822259 548714 [Tumour necrosis factor-alpha (TNF-alpha)] *induced* , RANTES and MIP-1beta mRNA expression , and lipopolysaccharide (LPS) induced MCP-1 , MIP-1alpha and MIP-1beta mRNA expression in astrocytes . Positive_regulation TNF CCL2 9825772 549213 Both chemokines were produced in response to IL-1alpha by SK-N-SH cells , while [TNF alpha] *induced* mainly production . Positive_regulation TNF CCL20 12748059 1149487 Expression of transcripts were significantly *induced* by interleukin (IL)-1beta and [tumor necrosis factor-alpha] , and inhibited by dexamethasone . Positive_regulation TNF CCL20 17619881 1815988 [TNF-alpha] *induced* but not IL-23 production in cultured synovial cells from RA patients . Positive_regulation TNF CCL21 10426368 632919 Accordingly , from hIL-13 treated mice secreted less interferon (IFN)-gamma upon ex vivo stimulation with Concanavalin A than controls , and anti-CD3 monoclonal antibody induced activation of T-cells in vivo *resulted* in lower blood levels of IFN-gamma and [tumor necrosis factor-alpha] and augmented blood levels of IL-4 in NOD mice pretreated with hIL-13 . Positive_regulation TNF CCL21 20126461 2207225 TWEAK , but not [TNFalpha] used as control ) , *induced* a delayed increase in CCL21a mRNA ( 3.5+/-1.22-fold over control ) and protein ( 2.5+/-0.8-fold over control ) , which was prevented by inhibition of the proteasome , or siRNA targeting of NIK or RelB , but not by RelA inhibition with parthenolide . Positive_regulation TNF CCL26 12061839 952944 Unlike Eotaxin-1 , mRNA expression was not *induced* by either [tumour necrosis factor (TNF)-alpha] or interleukin (IL)-1 beta alone . Positive_regulation TNF CCL26 20059579 2241573 [Tumour necrosis factor-alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) alone did not *induce* expression , yet these pro-inflammatory cytokines synergized with IL-4 to increase CCL26 protein expression . Positive_regulation TNF CCL27 15335355 1291147 We found that can be *induced* in cultured human keratinocytes by [tumor necrosis factor-alpha (TNF-alpha)] , but not by TARC alone . Positive_regulation TNF CCL27 15598438 1356641 can be *induced* in cultured keratinocytes by [tumor necrosis factor (TNF)-alpha] , which is also known to induce activity of the transcription factor NF-kappaB . Positive_regulation TNF CCL28 11382928 820945 There were no changes in the levels of p65 or c-rel . [TNFalpha] *induced* a pronounced and sustained increase of a p50 homodimeric NFkappaB/DNA complex in both normal and transformed . Positive_regulation TNF CCL28 16581045 1496452 IL-1beta and [TNF-alpha] *induce* increased expression of by airway epithelial cells via an NFkappaB dependent pathway . Positive_regulation TNF CCL28 20022349 2241198 In this study , we investigated whether CCL17 and transcription in cultured keratinocytes is *induced* by [TNF-alpha] , IL-1beta , or IFN-gamma . Positive_regulation TNF CCL3 17698589 1788663 *induces* a rapid [TNF-alpha] secretion by innate inflammatory mononuclear phagocytic cells ( MPCs ) , which further promotes the production of radical oxygen intermediates ( ROIs ) by both MPCs and neutrophils . Positive_regulation TNF CCL3 19234204 2040187 In vitro infection of lung DC indicated that in pDC , production of IFN-alpha , [TNF-alpha] , and CCL5 was *induced* only by hMPV , whereas and CCL4 were induced by both viruses . Positive_regulation TNF CCL3 9787141 541647 [TNF-alpha] *induced* receptor upregulation in a time- and concentration dependent manner . Positive_regulation TNF CCL3 9822259 548715 [Tumour necrosis factor-alpha (TNF-alpha)] induced MCP-1 , RANTES and MIP-1beta mRNA expression , and lipopolysaccharide (LPS) *induced* MCP-1 , and MIP-1beta mRNA expression in astrocytes . Positive_regulation TNF CCL4 11890657 894239 Specifically , LPS *induced* [TNFalpha] , MIP-1beta , and RANTES production in these cells , whereas the TLR2 agonists induced only production . Positive_regulation TNF CCL4 12708612 1082916 At the molecular level *activates* [tumor necrosis factor (TNF)alpha] , nitric oxide ( NO ) , and transforming growth factors ( TGF ) -alpha and -beta in the cell , processes that appear to direct the cell primarily toward ( self- ) destruction or fibrosis . Positive_regulation TNF CCL4 16141546 1451042 Oral pretreatment of liposomal lactoferrin exhibited more suppressive effects than did non-liposomal lactoferrin on *induced* hepatic injury in rats as well as on lipopolysaccharide induced [TNF-alpha] production from mouse peripheral blood mononuclear leukocytes . Positive_regulation TNF CCL4 16552805 1538043 We also found that GLPG reduced [TNF-alpha] level *induced* by in the plasma of mice , whereas increased SOD activity in the rat serum . Positive_regulation TNF CCL4 19234204 2040188 In vitro infection of lung DC indicated that in pDC , production of IFN-alpha , [TNF-alpha] , and CCL5 was *induced* only by hMPV , whereas CCL3 and were induced by both viruses . Positive_regulation TNF CCL4 23374533 2743274 Furthermore , the induced *upregulation* of [TNF-a] and Fas mRNA expression was significantly restored by the three treatments . Positive_regulation TNF CCL4 9822259 548716 [Tumour necrosis factor-alpha (TNF-alpha)] *induced* MCP-1 , RANTES and mRNA expression , and lipopolysaccharide (LPS) induced MCP-1 , MIP-1alpha and MIP-1beta mRNA expression in astrocytes . Positive_regulation TNF CCL5 20523058 2271278 Cooperative *activation* of expression by TLR3 and [tumor necrosis factor-alpha] or interferon-gamma through nuclear factor-kappaB or STAT-1 in airway epithelial cells . Positive_regulation TNF CCL7 24719782 2932013 [TNF] *induced* CCL2 , , and CXCL1 in preadipocytes but had no response in adipocytes . Positive_regulation TNF CCNA1 18787932 2012241 Post-translational modification of is associated with staurosporine and [TNFalpha] *induced* apoptosis in leukemic cells . Positive_regulation TNF CCNA2 15349890 1292347 In addition , the expression of hematopoietic cytokines and , repressed by OSM and matrigel , is *induced* by [TNFalpha] in the fetal hepatic cultures coincident with cell division . Positive_regulation TNF CCNA2 20164416 2215247 and a delayed response resulting from *induced* [TNF-alpha] , which acts as an autocrine/paracrine mediator to activate the expression of other cytokines including IL-1beta and IL-6 . Positive_regulation TNF CCNC 14982858 1214497 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF CCNC 18675993 2011389 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF CCNC 3292408 94716 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF CCND1 12730884 1086815 Leptin replacement corrected these defects in ob/ob mice by restoring [TNF] and IL-6 release and *inducing* . Positive_regulation TNF CCND1 18957422 2001153 Untimely *activation* of by [TNFalpha] can provide a potential mechanism for an involvement of TNFalpha in inflammation induced cancer . Positive_regulation TNF CCNT1 15879558 1406184 Disruption of function by the Cdk-inhibitor , DRB , or by small interfering RNA selectively *blocked* [TNFalpha] stimulation of IL-8 mRNA production . Positive_regulation TNF CCR1 17016504 1641499 However , results from both CCR1-deficient mice and human synovial membranes suggest that , in some experimental settings , blocking could *enhance* [TNF] production . Positive_regulation TNF CCR2 17938380 1825689 Renal tumor necrosis factor-alpha and intercellular adhesion molecule-1 expression increased , and Cyp2c23 expression decreased in ANG/HS hypertension compared with the HS group , and inhibition *reduced* [tumor necrosis factor-alpha] and intercellular adhesion molecule-1 and increased Cyp2c23 expression . Positive_regulation TNF CD14 10417128 631455 The objective of the present study was to investigate whether the production of [tumor necrosis factor alpha (TNF)] and interleukin-10 (IL-10) by human monocytes stimulated by intact heat killed or live Haemophilus influenzae or Streptococcus pneumoniae is *mediated* by . Positive_regulation TNF CD14 10458778 639545 Both CD3 ( + ) and ( + ) populations are *required* for this early [TNF] response to Pfe , whereas the endotoxin induced response is unaffected by depletion of the CD3 ( + ) population . Positive_regulation TNF CD14 10770808 686081 We also show that is *required* for optimal [TNF-alpha] responses at low concentrations . Positive_regulation TNF CD14 10865171 705896 Ornithine containing lipids stimulate *dependent* [TNF-alpha] production from murine macrophage-like J774.1 and RAW 264.7 cells . Positive_regulation TNF CD14 11801529 902551 Furthermore , up-regulation of TLR2 and CD14 mRNA expression by PMA was abrogated by a protein kinase C inhibitor , Calphostine C , suggesting the up-regulation of TLR2 and CD14 mRNA is dependent on the activation of protein kinase C. Coexpression of CD14/TLR2 and/or may be *essential* but not sufficient for the production of [tumor necrosis factor-alpha] in response to lipopolysaccharide in our system . Positive_regulation TNF CD14 11829837 581354 Excessive mRNA expression may *enhance* synthesis and release of [TNF-alpha] stimulated by endotoxin translocation , and the interaction between CD14 and TNF-alpha may play an important role in mediating multiple organ damage secondary to major burns . Positive_regulation TNF CD14 17975091 1820639 The two L. pneumophila lpxB paralogues are not functionally equivalent , since expression of lcsC/lpxB1 but not lpxB2 in an L. pneumophila icmG mutant is cytotoxic for A. castellanii , and LPS purified from the two strains triggers *dependent* [tumour necrosis factor (TNF)alpha] production by macrophages with a different potency . Positive_regulation TNF CD14 19796811 2159360 The interaction of UV-HCMV and HCMV with on the surface of ST-like cells *increases* [TNFalpha] expression and induces apoptosis in the population . Positive_regulation TNF CD14 20729207 2330375 We showed that the production of [tumor necrosis factor (TNF)] a by macrophages in response to Toxoplasma gondii glycosylphosphatidylinositols ( GPIs ) *requires* the expression of both Toll-like receptors TLR2 and TLR4 , but not of their co-receptor . Positive_regulation TNF CD14 23669238 2823325 These data indicate that SR-A is *required* for maximal production of [TNF-a] in cells stimulated with LPS , possibly by modulating the cell surface levels of TLR4 and . Positive_regulation TNF CD14 24068451 2920988 was *involved* in LAMP stimulated production of [tumor necrosis factor (TNF)-a] by blocking CD14 antibody in THP-1 cells . Positive_regulation TNF CD14 24068451 2920998 In addition , LAMP induced [TNF-a] release was *increased* by soluble but decreased by soluble TLR2 . Positive_regulation TNF CD14 24166974 2868289 Sialylation of Campylobacter jejuni endotoxin promotes dendritic cell mediated B cell responses through *dependent* production of IFN-ß and [TNF-a] . Positive_regulation TNF CD14 24489448 2884806 At higher doses of both LPS forms ( 100-1000 ng/mL ) , [TNF-a] release *required* to much lower extent . Positive_regulation TNF CD14 24489448 2884808 Among the two forms of LPS , rLPS induced [TNF-a] production was less *dependent* and could proceed in the absence of serum as an LBP source . Positive_regulation TNF CD14 7507190 244537 *mediated* endogenous [TNF-alpha] release in HL60 AML cells : a potential model for CD14 mediated endogenous cytokine release in the treatment of AML . Positive_regulation TNF CD14 7528733 291387 Anti-CD14 monoclonal antibodies MY4 and 3C10 inhibited LPS binding protein and dependent *activation* of [TNF-alpha] production by LPS at LPS concentrations up to approximately 1.0 ng/ml. R-HDL ( 2 mg of protein per ml ) blocked TNF-alpha production by LPS from both smooth- and rough-type gram negative bacteria at concentrations up to 100 ng of LPS per ml but had little effect on heat killed gram positive Staphylococcus aureus and no effect on other LPS independent stimuli tested . Positive_regulation TNF CD14 7545713 323054 Indeed , *mediated* release of [TNF-alpha] was inhibited markedly ( approximately 75 % ) in monocytes stimulated with LPS ( 100 ng/ml ) after a 72-h preincubation with IL-13 . Positive_regulation TNF CD14 7681082 214209 We conclude that is *involved* in LPS induced release of [TNF-alpha] , IL-6 , and IL-8 by monocytes and alveolar macrophages and that this receptor appears to be able to recognize LPS directly in the absence of serum . Positive_regulation TNF CD14 7681399 214250 Moreover , [TNF] *induced* a moderate increase of surface antigen expression , used as a phenotypic marker of monocyte/macrophage differentiation . Positive_regulation TNF CD14 7685250 219748 Lipopolysaccharide binding protein and interaction *induces* [tumor necrosis factor-alpha] generation and neutrophil sequestration in lungs after intratracheal endotoxin . Positive_regulation TNF CD14 8614033 353586 The inhibition *resulted* in a 55 % reduction in baseline [TNF] activity . Positive_regulation TNF CD14 8751905 377223 With Escherichia coli LPS , [tumor necrosis factor] alpha activation requires membrane bound CD14 and E-selectin expression *requires* soluble ( sCD14 ) . Positive_regulation TNF CD14 8975923 408651 The results indicate that ( i ) induction of TNF-alpha by C. neoformans and GXMs strongly depends on complement , ( ii ) MP1 and MP2 induction of TNF-alpha is facilitated by a heat-stable serum factor other than Ig , and ( iii ) may be *involved* in the induction of [TNF-alpha] by MP2 . Positive_regulation TNF CD14 9353071 461323 [TNF-alpha] *induced* a transient increase in levels of in plasma with a peak at 6 to 8 h , and this increase in levels of CD14 antigen in plasma was accompanied by increased levels of CD14 mRNA in lung , liver , and kidney . Positive_regulation TNF CD14 9574560 502556 This study was undertaken to evaluate the *role* of and complement receptors type 3 (CR3) and 4 ( CR4 ) in mediating [TNF] release and NF-kappaB activation induced by LPS and cell wall preparations from group B streptococci type III ( GBS ) . Positive_regulation TNF CD14 9574560 502567 LPS and GBS caused [TNF] secretion from human monocytes in a CD14 dependent manner , and soluble , LPS binding protein , or their combination *potentiated* both LPS- and GBS induced activities . Positive_regulation TNF CD151 1633264 193905 We conclude that *induces* [TNF-like] factor production , resulting in destruction and dissolution of the xenograft after 5 days . Positive_regulation TNF CD160 18976941 2113868 In addition , our data show that peripheral receptors *mediate* the production of both [TNFalpha] and IL-1beta in the TMJ as well as some of the inflammatory signs , such as plasma extravasation and leukocyte influx , but not the nociceptive component . Positive_regulation TNF CD163 23922818 2826335 In IBD blood and mucosal cell cultures , cross linking of with a specific monoclonal anti-CD163 antibody *enhanced* [tumor necrosis factor-a] synthesis . Positive_regulation TNF CD180 21918197 2492002 had no effect on cytokine production from B cells , but it *increased* IL-6 , IL-10 , and [TNF-a] production in combination with LPS or CpG . Positive_regulation TNF CD1B 12553063 1028938 The results show that could *stimulate* PBMCs release of IL-1 beta , IL-2 and [TNF-alpha] and then activate T cells . Positive_regulation TNF CD1D 15708985 1373269 TNF-alpha treatment of uninfected endothelial cells had only a modest effect on CD1d expression , suggesting that optimal upregulation *requires* both infection and [TNF-alpha] signaling . Positive_regulation TNF CD2 11034358 740681 *induced* proliferation as well as production of [TNF-alpha] and IFN-gamma was abrogated in ZAP-70-deficient T cells , whereas PMA plus ionomycin induced normal activation of these cells . Positive_regulation TNF CD2 1353987 192649 rIL-1 beta supported *induced* [TNF-alpha] production indirectly through an IL-2 dependent pathway . Positive_regulation TNF CD2 1353987 192654 We conclude that CD3 or triggering are not *sufficient* for [TNF-alpha] production by T cells , but that the latter is dependent ( apparently at the transcriptional level ) on the interaction of IL-2 with its functionally active cell surface receptors . Positive_regulation TNF CD2 8972736 402966 Mannose-6-phosphate , an inhibitor of L-selectin binding , blocked *induced* [TNF] production whereas other ligands for L-selectin ( the monomeric monoclonal antibody to L-selectin , DREG-200 ; inositol hexaphosphoric acid ; heparin ) amplified CD2 induced secretion of TNF . Positive_regulation TNF CD200 19386363 2081978 All the above findings suggest that IFN-gamma and [TNF-alpha] *induce* expression through a 5 ' upstream enhancer and that NF-kappaB , STAT1 and IRF-1 play pivotal roles in this process . Positive_regulation TNF CD209 18405996 1914218 enhances infection of cells with glycosylated West Nile virus in vitro and virus replication in human dendritic cells *induces* production of IFN-alpha and [TNF-alpha] . Positive_regulation TNF CD209 20080962 2218738 In THP-1 cells and human MDDCs , interaction *led* to the activation of Raf-1 and ERK kinases and the induction of [tumor necrosis factor-alpha] expression . Positive_regulation TNF CD244 16684368 1663367 Blockade of beta2 integrins and membrane bound IL-15 inhibited TNF production , whereas [TNF] synthesis increased in the *presence* of anti-CD48 and ( 2B4 ) monoclonal antibodies . Positive_regulation TNF CD27 16923852 1608651 In this study , we show that during LCMV infection , signaling on CD4+ T cells *enhances* the secretion of interferon-gamma and [tumor necrosis factor-alpha] . Positive_regulation TNF CD274 10549624 565004 , a novel costimulatory homolog of B7.1 and B7.2 , is *induced* by [TNFalpha] . Positive_regulation TNF CD274 16129490 1507335 Flow cytometric analysis revealed that but not B7-DC constitutively expresses on TECs , and the B7-H1 protein expression was profoundly *up-regulated* by the stimulation of [TNF-alpha] with a dose dependent manner . Positive_regulation TNF CD274 17507101 1751012 However , the surface expression of was *induced* by IFN-gamma but not [TNF-alpha] and similarly functional IDO expression was only induced by IFN-gamma stimulation . Positive_regulation TNF CD274 20472834 2301092 Using MDS cell lines and patient samples , we showed that the expression of an immunoinhibitory molecule , ( CD274 ) , was *induced* by interferon-gamma (IFNgamma) and [tumor necrosis factor-alpha (TNFalpha)] on MDS blasts . Positive_regulation TNF CD28 10928971 719639 FK506 inhibited *induced* [TNF-alpha] and IL-1beta production at concentrations less than 1 ng ml(-1) . Positive_regulation TNF CD28 11762949 887864 In contrast , splenic lymphocytes ( CD3+ , CD4+ , or CD8+ ) derived from wild-type and TIA-1-/- mice produced similar amounts of [TNFalpha] in *response* to Con A , PMA/ionomycin , or . Positive_regulation TNF CD28 1309488 178307 These results thus document that T cell activation via *results* in a marked increase in [TNF-alpha] production without affecting the functional disparity that exists between naive and memory T cells . Positive_regulation TNF CD28 16137665 1467172 *regulates* glucocorticoid induced [TNF] receptor family related gene expression on CD4+ T cells via IL-2 dependent mechanisms . Positive_regulation TNF CD28 16434693 1540476 However , compared with stimulation with phorbol 12-myristate 13-acetate plus ionomycin , jacalin plus *resulted* in decreased levels of [tumor necrosis factor] alpha secretion . Positive_regulation TNF CD28 16585559 1544186 Splenic T cells from aly/aly mice ( that have a defective NIK protein ) have a severe impairment in IL-2 and GM-CSF but not [TNF] secretion in *response* to . Positive_regulation TNF CD28 16630028 1551973 Both total colonic and mesenteric lymphocyte *stimulated* [TNF-alpha] levels were dramatically reduced under the same circumstances . Positive_regulation TNF CD28 21931118 2516077 Preclinical tests using human PBMCs had failed to announce the rapid release of [TNF] , IFN-? , and other toxic cytokines in *response* to this . Positive_regulation TNF CD28 22349068 2576555 and reduced IL-4 and [TNF-a] production *following* activation . Positive_regulation TNF CD28 22591674 2669475 We then determined the effect of 3PO on *induced* T cell activation , F2,6BP synthesis , 2- [ 1-14C ] -deoxy-d-glucose uptake , lactate secretion , [TNF-a] secretion and proliferation . Positive_regulation TNF CD28 7511644 250172 IL-2 activated NK cells produced enhanced levels of IFN-gamma and [TNF] in *response* to stimulation with and PMA . Positive_regulation TNF CD28 7678624 209951 ligation *induced* production of [TNF-alpha] , but not of IL-4 , and did not induce modulation of the TCR/CD3 complex . Positive_regulation TNF CD28 8095456 211928 associated to CD3 or CD2 *induced* high levels of IL-2 , [tumor necrosis factor (TNF)] and IL-4 secretion for 10 days , in contrast to CD3 alone which induced only TNF secretion . Positive_regulation TNF CD28 8557665 347525 The c-Jun N-terminal kinases (JNK) are activated by various stimuli , including UV light , interleukin-1 , [tumor necrosis factor-alpha (TNF-alpha)] , and *costimulation* . Positive_regulation TNF CD28 8621542 360042 The Rel family of transcription factors are important mediators of various cytokine stimuli such as interleukin (IL)-1 , [tumor necrosis factor (TNF)-alpha] , and *costimulation* in T cell effector responses . Positive_regulation TNF CD28 9510155 491828 FK506 also reduced *induced* production of IL-3 , IL-4 , IL-10 , [TNF-alpha] , and IL-6 but augmented that of GM-CSF , IL-5 , IFN-gamma , and IL-13 . Positive_regulation TNF CD28 9603908 506982 Expression of a dominant negative form of Cot kinase inhibits [TNF-alpha] promoter activation *induced* by stimulation with either calcium ionophore and PDBu , soluble and PDBu , or soluble anti-CD3 and PDBu . Positive_regulation TNF CD300A 18535206 1945552 *regulate* type I interferon and [TNF-alpha] secretion by human plasmacytoid dendritic cells stimulated with TLR7 and TLR9 ligands . Positive_regulation TNF CD300E 15557162 1340358 moreover , engagement on monocytes *induced* [TNF-alpha] production . Positive_regulation TNF CD36 20404035 2246078 [TNF-alpha] also *induced* and peroxisome proliferators activated receptor ( Ppar)gamma expression , as well as microsomal triglyceride transfer protein ( Mtp ) protein and mRNA , but suppressed the sterol regulatory element binding protein ( Srebp)1c protein and mRNA level . Positive_regulation TNF CD38 17217567 1682013 *increased* [TNF-alpha] mRNA expression and production by PBMC . Positive_regulation TNF CD38 18234254 1924597 also *increased* [TNF-alpha] production by PBMC . Positive_regulation TNF CD38 22773691 2659878 In human ASM ( HASM ) cells , [TNF-a] *induces* expression through activation of MAPKs , NF-?B , and AP-1 , and its expression is differentially elevated in cells from asthmatic patients compared with cells from nonasthmatic subjects . Positive_regulation TNF CD3D 7678624 209952 CD5/CD28 ligation induced production of [TNF-alpha] , but not of IL-4 , and did not *induce* modulation of the complex . Positive_regulation TNF CD3D 8794353 381192 [Tumor necrosis factor] protein secretion was also *increased* to a greater extent by than by T1L in primary rat AMs and the NR8383 cells . Positive_regulation TNF CD3E 7678624 209953 CD5/CD28 ligation induced production of [TNF-alpha] , but not of IL-4 , and did not *induce* modulation of the complex . Positive_regulation TNF CD3G 7678624 209954 CD5/CD28 ligation induced production of [TNF-alpha] , but not of IL-4 , and did not *induce* modulation of the complex . Positive_regulation TNF CD4 11401990 824758 In a coculture system , CT-treated ( + ) T cells *induced* significantly less [TNF-alpha] and IL-12 p70 production by both autologous monocytes and monocyte derived dendritic cells than either LT-IIa- or LT-IIb treated CD4 ( + ) T cells . Positive_regulation TNF CD4 1628901 191842 We observed that antigen expression on ML3 cells is almost undetectable and that [TNF] and IFN-gamma *induced* CD4 antigen expression on these cells . Positive_regulation TNF CD4 17644042 1780298 Furthermore IL-15 stimulated CD57 ( + ) CD28 ( - ) ( + ) T cells *induced* [TNF-alpha] production from monocytes . Positive_regulation TNF CD4 1921451 168512 [TNF] *induced* expression of and CD71 , increased the intensity of HLA-DR , CD25 , CD11c and CD13 expression and decreased both the intensity and frequency of sIg and cIg positivity . Positive_regulation TNF CD4 19568710 2104586 The level of CD3 ( + ) , ( + ) , the ratio of CD4 and CD8 ( + ) , IgA , IgM , IgG and IL-2 decreased in patients with NSCLC on day 1 after operation , and the level of CD8 and [TNF-alpha] *increased* compared to pre-operation . Positive_regulation TNF CD4 21216963 2397062 Level of [TNF-a] and IFN-? decreased in the presence of anti-factor B. Collectively , our results provide the novel finding that complement activation via the alternative pathway contributes to intraocular inflammation in EAAU , and anti-factor B-mediated inhibition of EAAU is *due* to diminished antigen-specific ( + ) T cell responses to MAA . Positive_regulation TNF CD4 24595607 2920506 We found that tularinum induced ( + ) T-cells *increased* [TNF-a] and IFN-? synthesis and expression of CD69 only in group mice with high degree of post immunization protection against F. tularensis Schu challenge . Positive_regulation TNF CD4 2475571 116902 Depletion of the and CD8 T lymphocytes by an in vivo treatment with mAb *prevented* the bleomycin induced increase of [TNF] mRNA level and fibrosis . Positive_regulation TNF CD4 7511077 250031 We conclude that dependent binding to the cell surface is *sufficient* to enhance [TNF-alpha] and IL-1 beta mRNA , whereas productive viral replication in primary human macrophages is not required . Positive_regulation TNF CD4 7522637 272106 In addition , *resulted* in the induction of interferon-gamma (IFN-gamma) and [tumor necrosis factor-alpha (TNF-alpha)] in the absence of interleukin-2 (IL-2) and IL-4 secretion in PBMCs . Positive_regulation TNF CD4 7572384 328893 in PBMC also *resulted* in induction of the cytokines INF-tau and [TNF-alpha] in the absence of IL-2 and IL-4 secretion . Positive_regulation TNF CD4 8630399 356433 These data suggest that vesnarinone inhibits *induced* [TNF-alpha/IFN-gamma] secretion , thereby blocking subsequent Fas upregulation and apoptosis induction . Positive_regulation TNF CD4 9269777 450113 cross linking ( CD4XL ) *induces* RAS activation and [tumor necrosis factor-alpha] secretion in CD4+ T cells . Positive_regulation TNF CD4 9269777 450125 CD4+ T cells expressing dn-ras secreted significantly reduced levels of [TNF-alpha] in *response* to . Positive_regulation TNF CD40 10026206 591304 Together , the data demonstrate that mediated *induction* of IL-1beta and [tumor necrosis factor-alpha] synthesis is dependent on a MEK/ERK pathway which is obstructed by signals generated through the action of IL-4 and IL-10 . Positive_regulation TNF CD40 10096561 601445 ligation on MM by CD40L transfected murine L-cells or by a soluble CD40L fusion protein *up-regulated* their expression of intercellular adhesion molecule-1 and MHC class I and class II molecules and their secretion of IL-6 , IL-8 , [tumor necrosis factor-a] , and granulocyte macrophage colony stimulating factor and also induced a rapid activation of the transcription factor nuclear factor kappaB . Positive_regulation TNF CD40 10332965 614901 Ligation of *induced* [tumor necrosis factor-alpha] in rheumatoid arthritis : a novel mechanism of activation of synoviocytes . Positive_regulation TNF CD40 10332965 614906 IL-10 exerted inhibitory effects on both CD40 ligation induced and ligation plus IFN-gamma *induced* [TNF-alpha] production by ST cells . Positive_regulation TNF CD40 10408982 626306 We also find that ligation of microglial by CD40L *triggers* a significant production of [TNF-alpha] . Positive_regulation TNF CD40 10586056 571696 Ligation of microglial *results* in p44/42 mitogen activated protein kinase dependent [TNF-alpha] production that is opposed by TGF-beta 1 and IL-10 . Positive_regulation TNF CD40 10586056 571764 Furthermore , cotreatment of microglial cells with CD40 ligand and TGF-beta1 or IL-10 , or both , inhibits *mediated* activation of p44/42 MAPK and production of [TNF-alpha] in a statistically interactive manner . Positive_regulation TNF CD40 10586056 571778 Taken together , these data show that ligation of microglial *triggers* [TNF-alpha] release through the p44/42 MAPK pathway , an effect that can be opposed by TGF-beta1 and IL-10 . Positive_regulation TNF CD40 11304555 803715 Differential signaling and [tumor necrosis factor] receptor associated factor ( TRAF ) degradation *mediated* by and the Epstein-Barr virus oncoprotein latent membrane protein 1 (LMP1) . Positive_regulation TNF CD40 11754002 898757 The specific TRAF dependency of *induced* growth arrest , [TNF-alpha] production , and phosphorylation of signaling molecules are shown , while p38 MAPK activation and cell surface antigen modulation suggest TRAF independent CD40 signaling in B cells . Positive_regulation TNF CD40 11907088 923255 Here we demonstrate that *induced* [TNF] stimulates IgM production through CD120b and that CD120b signaling is required for optimal CD40 induced IgM secretion . Positive_regulation TNF CD40 12039918 949567 These data show that ligation *induced* secretion of IL-6 and IL-8 , but not [TNF-alpha] and IL-10 , is partially mediated via IL-1 and that IL-1 plays a prominent role in the inflammatory response initiated by CD40 ligation in intact human skin . Positive_regulation TNF CD40 12067408 955018 CD34 expression was gradually lost , so that by day 9 , the majority of the cells were CD34 ( - ) /CMRF-44 ( + ) . GM-CSF and [TNF-alpha] also *induced* expression , and up-regulation of CD54 and MHC class II on CD34 ( + ) cells ; Positive_regulation TNF CD40 12220533 986938 *mediated* [tumor necrosis factor] receptor associated factor 3 signaling upregulates IL-4 induced germline Cepsilon transcription in a human B cell line . Positive_regulation TNF CD40 14604983 1187729 Synergistic B cell activation by and the B cell antigen receptor : role of B lymphocyte antigen receptor *mediated* kinase activation and [tumor necrosis factor] receptor associated factor regulation . Positive_regulation TNF CD40 14729358 1198386 In the primary cultured cells , [TNFalpha] *induced* an important upregulation of ICAM-1 , Fas and whereas CD44 and CD63 were significantly decreased . Positive_regulation TNF CD40 15240722 1270432 The production of TNF and IL-1beta was induced by membranes of stimulated T cells in the three types of target cells , whereas *induced* [TNF] production in IFN-gamma-macrophages only . Positive_regulation TNF CD40 15240722 1270436 *induced* neither transcript nor protein of cytokines in monocytes , whereas in IFN-gamma-macrophages , IL-1beta and TNF mRNA were observed , but only [TNF] was measured in cell supernatants . Positive_regulation TNF CD40 15240722 1270438 Finally , anti-CD40L Abs failed to inhibit TNF and IL-1beta production induced in IFN-gamma-macrophages by solubilized membranes , whereas [TNF] production *induced* by was inhibited . Positive_regulation TNF CD40 15356572 1293178 Immunologic function was variably impaired , with reduced *induced* B-cell proliferation , partially reduced NF-kappa B p65 nuclear translocation , and variable Toll-like receptor induced [TNF] production . Positive_regulation TNF CD40 15716074 1389017 engagement *induced* comparable [TNF-alpha] production in macrophages from both strains . Positive_regulation TNF CD40 16025512 1435664 These in vitro studies demonstrated that [TNF-alpha] induces CD40 expression in hepatocytes and that subsequent activation of results in hepatocyte apoptosis *mediated* at least in part by enhanced hepatocyte expression of FasL . Positive_regulation TNF CD40 16552709 1542087 [TNF-alpha] significantly *induced* B7-H2 and expression by A549 cells , but had no effect on B7-1 or B7-2 expression . Positive_regulation TNF CD40 17082576 1643210 IL-10 prevents the *induced* CTL and [TNF-alpha] and IL-12 production , Th1 skewing , and tumor regression . Positive_regulation TNF CD40 17805323 1822868 In addition , stimulation of the receptor on purified PB monocytes *led* to a significantly higher [tumor necrosis factor] alpha production in patients . Positive_regulation TNF CD40 18949670 1982404 We therefore determined the baseline expression and *mediated* modulation of [TNF] receptor and costimulatory molecules in 5 patients with proB-ALL , 8 with preB-ALL and 22 with c-ALL performing FACS analysis . Positive_regulation TNF CD40 19220210 2105896 [TNF-alpha] and IFN-gamma *induced* via nuclear factor-kappaB (NF-kappaB) and signal transducer and activator of transcription-3 in both cell types and modulated OX40L via NF-kappaB and c-Jun N terminal kinase in nonasthmatic cells . Positive_regulation TNF CD40 20530686 2277460 The I3C dependent accumulation of full-length unprocessed protein *caused* a shift in CD40 signaling through [TNF receptor associated factors (TRAF)] , including the TRAF1/TRAF2 positive regulators and TRAF3 negative regulator of NF-kappaB transcription factor activity . Positive_regulation TNF CD40 21071692 2349612 Enhanced levels of soluble CD40 ligand exacerbate platelet aggregation and thrombus formation through a *dependent* [tumor necrosis factor] receptor associated factor-2/Rac1/p38 mitogen activated protein kinase signaling pathway . Positive_regulation TNF CD40 22010829 2539711 Critical role of *mediated* autocrine [tumor necrosis factor-alpha] in potentiation of cisplatin induced cytotoxicity in cancer cells . Positive_regulation TNF CD40 22504646 2589517 Neutralization of TNF confirmed that DC survival was mediated by autocrine [TNF] *induced* either by stimulation with R-848 or by ligation of . Positive_regulation TNF CD40 23072727 2716896 Our study indicates that sleep-wake dysregulation in autoimmune diseases may result from *induced* [TNF] : TNFR1 mediated alterations of molecular pathways , which regulate sleep-wake behavior . Positive_regulation TNF CD40 7535097 287773 Induction of TNF-alpha mRNA was inhibited by actinomycin D suggesting that ligation *results* in transcriptional activation of the [TNF-alpha] and LT-alpha genes . Positive_regulation TNF CD40 7535097 287775 *caused* minimal increase in the expression of [TNF-alpha] on the B cell membrane and no detectable secretion of TNF-alpha . Positive_regulation TNF CD40 8977185 408677 Using CD40-ligand transfected L cells (CD40Lc) , we demonstrated that triggering *results* in an enhanced secretion of both IL-8 and [TNF-alpha] by cultured epidermal basal cells , suggesting that CD40-CD40L interactions may play a role in amplifying the cutaneous inflammatory reactions . Positive_regulation TNF CD40 8980186 403718 Expression of CD40 protein was *increased* in 2 of 3 cell lines with constitutive expression by interferon-gamma but not by granulocyte/macrophage colony stimulating factor , interleukin-2 or [tumor necrosis factor-alpha] . Positive_regulation TNF CD40 9764595 537356 also *augmented* [tumour necrosis factor-alpha (TNF-alpha)] and granulocyte-macrophage colony stimulating factor ( GM-CSF ) expression but resulted in decreased IL-10 expression . Positive_regulation TNF CD40 9842907 552988 We show that the *induced* production of IL-6 , IL-8 and [TNF-alpha] by monocytes , and IL-12 by dendritic cells , and expression of the activation markers CD83 , the costimulatory molecules CD86 and CD80 , and HLA-DR antigens were all similar in patient and control cells . Positive_regulation TNF CD40LG 10096561 601446 CD40 ligation on MM by CD40L transfected murine L-cells or by a soluble fusion protein *up-regulated* their expression of intercellular adhesion molecule-1 and MHC class I and class II molecules and their secretion of IL-6 , IL-8 , [tumor necrosis factor-a] , and granulocyte macrophage colony stimulating factor and also induced a rapid activation of the transcription factor nuclear factor kappaB . Positive_regulation TNF CD40LG 10820273 694420 These studies show that coincident expression of enhances the Th1 ( IL-2 and IFN-gamma ) cytokine responses , *increases* the expression of [TNF-alpha] and NO , accelerates virus clearance , and increases the anti-F and anti-G Ab responses . Positive_regulation TNF CD40LG 10940869 721093 Furthermore , Dex-DC showed a decreased *induced* IL-6 and [TNF-alpha] production , a complete block in IL-12p40 production , while IL-10 production was unaffected . Positive_regulation TNF CD40LG 11275268 797779 Morphological features and mechanisms of cytokine production resemble those observed in microglia -- T cell co-cultures since CTLA-4 and CD40 -- blockades *reduce* [TNF-alpha] and IL-10 levels , while anti-CD23 inhibits IL-10 only in U937 -- T cell interactions . Positive_regulation TNF CD40LG 11841573 912183 Furthermore , although not directly inducing tumor necrosis factor-alpha (TNF-alpha) release , PAR1 activation up-regulates microglial CD40 expression and potentiates *induced* [TNF-alpha] production , thus indirectly contributing to microglial activation . Positive_regulation TNF CD40LG 12207328 983560 Human lung myofibroblasts as effectors of the inflammatory process : the common receptor gamma chain is induced by Th2 cytokines , and is *induced* by lipopolysaccharide , thrombin and [TNF-alpha] . Positive_regulation TNF CD40LG 15231570 1321996 stimulation *induced* significant secretion of [tumor necrosis factor alpha (TNFalpha)] and interleukin 12 (IL-12) p70 from both HIV-1 exposed and unexposed DCs . Positive_regulation TNF CD40LG 15315967 1353563 Importantly however , the inability of SzS PBMCs to appropriately produce IL-12 and [TNF-alpha] could be *restored* by recombinant hexameric . Positive_regulation TNF CD40LG 17312171 1699706 Finally , the *mediated* increase in [TNF-alpha] production by monocytes was shown to be biologically important ; Positive_regulation TNF CD40LG 18603779 1941601 Furthermore , [TNF-alpha] *induced* activity was greatly inhibited by YSP ( 100 microg/ml ) treatment . Positive_regulation TNF CD40LG 21187391 2378865 is also *required* for ovx to activate T cells and stimulate their production of [TNF] . Positive_regulation TNF CD40LG 22784440 2719533 did not *stimulate* the secretion of IL-10 , IL-12 , [TNF-a] or IFN-? and did not stimulate migration toward CCL19 or CCL21 . Positive_regulation TNF CD40LG 23073798 2690042 The stimulation of CD40+ glioma cells with soluble ( CD154 ) *up-regulated* the expression of [TNF-a] at both mRNA and protein levels . Positive_regulation TNF CD40LG 7510740 249997 In addition to proliferation , *induces* lectin mediated cytolytic activity in thymic gamma delta T cells as well as the production of IFN-gamma and [TNF-alpha] . Positive_regulation TNF CD40LG 7522624 272091 We found that recombinant induced interleukin-8 (IL-8) secretion and *enhanced* IL-6 , [TNF] , and lymphotoxin-alpha ( LT-alpha/TNF-beta ) release from cultured H-RS cells . Positive_regulation TNF CD40LG 7621881 315657 We have found that both the recombinant CD30L and *enhanced* interleukin (IL)-6 , [TNF] and lymphotoxin (LT)-alpha release from cultured H-RS cells . Positive_regulation TNF CD40LG 9632061 512587 [TNF-alpha] secretion from RA SFMC was *enhanced* by stimulation . Positive_regulation TNF CD44 10222064 609560 [TNFalpha] and IL-4 regulation of hyaluronan binding to monocyte CD44 *involves* posttranslational modification of . Positive_regulation TNF CD44 12867430 1141878 [Tumor necrosis factor-alpha] *induces* functionally active hyaluronan-adhesive by activating sialidase through p38 mitogen activated protein kinase in lipopolysaccharide stimulated human monocytic cells . Positive_regulation TNF CD44 16022734 1453197 *induces* the production of NO and [TNF-alpha] by murine microglia . Positive_regulation TNF CD44 8792802 381016 IL-1 beta showed the strongest stimulatory effect on the expression of ICAM-1 , [TNF-alpha] preferentially *induced* the expression of VCAM-1 and , and Et-1 strongly stimulated the upregulation of CD-44 expression . Positive_regulation TNF CD44 9766501 538163 [TNF-alpha] , but not IFN-gamma also *induced* the activation of LFA-1 , and beta1 integrins on SR-91 cells . Positive_regulation TNF CD46 15211029 1262153 We observed constitutive expression of interleukin (IL)-6 , IL-8 , granulocyte macrophage colony stimulating factor ( GM-CSF ) , and in both human and baboon endothelial cells , and these cytokines were further *induced* by [TNF-alpha] and LPS . Positive_regulation TNF CD46 17673686 1842309 Using a transformed murine Clara cell line ( C22 ) , we observed that both LPS and [TNF-alpha] *induced* production of keratinocyte derived chemokine ( KC ) and . Positive_regulation TNF CD46 21545652 2449282 Although these two cytokines had no effect on and CD55 gene expression in epithelial cells , IL-1ß and [tumor necrosis factor-a] *induced* a significant upregulation . Positive_regulation TNF CD46 23512893 2843504 FFAs *increased* the expression of tumor necrosis factor ( [TNF] ) a , interleukin (IL)-6 , and in SC and omental preadipocytes . Positive_regulation TNF CD47 16924232 1692183 [TNF] *induced* the expression of NF-kappaB regulated gene products cyclin D1 , c-Myc , matrix metalloproteinase-9 , survivin , X-linked inhibitor-of-apoptosis protein ( IAP ) , , Bcl-x ( L ) , A1/Bfl-1 and Fas associated death domain protein-like IL-1beta converting enzyme-inhibitory protein in wild-type MEF but not in PKR-/- cells . Positive_regulation TNF CD47 20844955 2401455 whole-blood stimulation with LPS and Pam-3-Cys *resulted* in increased IL-6 and [tumor necrosis factor (TNF)-alpha] secretion compared with WT . Positive_regulation TNF CD48 10393956 627322 The mast cell [tumor necrosis factor] alpha response to FimH expressing Escherichia coli is *mediated* by the glycosylphosphatidylinositol anchored molecule . Positive_regulation TNF CD48 16684368 1663366 Blockade of beta2 integrins and membrane bound IL-15 inhibited TNF production , whereas [TNF] synthesis increased in the *presence* of and anti-CD244 ( 2B4 ) monoclonal antibodies . Positive_regulation TNF CD5 7678624 209955 ligation *induced* production of [TNF-alpha] , but not of IL-4 , and did not induce modulation of the TCR/CD3 complex . Positive_regulation TNF CD55 21545652 2449281 Although these two cytokines had no effect on CD46 and gene expression in epithelial cells , IL-1ß and [tumor necrosis factor-a] *induced* a significant upregulation . Positive_regulation TNF CD58 8525920 326444 In preliminary experiments with fluorescence microscopy we found that neither [TNF-alpha] nor IL-1 beta *induce* in the same fashion as IFN-gamma . Positive_regulation TNF CD58 9767437 538641 This response profile differs from that observed in B7 or LFA-3 costimulated T cells because our previous results showed that B7-CD28 costimulation was accompanied by high levels of IL-2 , IFN-gamma and TNF , whereas was a potent *inducer* of IFN-gamma and [TNF] , but had little influence on IL-2 production . Positive_regulation TNF CD59 7688580 225383 The level of was far greater than that of DAF or MCP on EC , and was slightly *up-regulated* by [TNF-alpha] and down-regulated by IL-1 beta . Positive_regulation TNF CD69 10594567 573069 Furthermore , in BD a significantly increased proportion of the gammadelta T cell population expressed and high levels of CD29 and were *induced* to produce IFN-gamma and [TNF-alpha] compared with healthy controls . Positive_regulation TNF CD69 12718936 1030628 cross linking on GM-CSF primed neutrophils sinergized with LPS and *increased* [TNF-alpha] production and secretion suggesting a role for CD69 positive neutrophils in the pathogenesis and maintenance of different inflammatory diseases . Positive_regulation TNF CD69 15551947 1338640 of this investigation was to compare the effects of 10 ( -4 ) M and 10 ( -7 ) M As compounds on spontaneous and PHA *stimulated* PBMC proliferation and IFN-gamma and [TNF-alpha] release . Positive_regulation TNF CD79A 15039391 1224298 We also demonstrated that , in synergy with IFN-gamma , *induced* [TNF-alpha] production and apoptosis of thioglycollate elicited mouse peritoneal macrophages . Positive_regulation TNF CD79A 17393381 1721042 Moreover , from IgAN patients activated FcalphaRI and *induced* [TNF-alpha] production . Positive_regulation TNF CD79A 17898021 1849063 Our results suggest that polymeric anionic could activate HMC and *increase* the synthesis of [TNF-alpha] and IL-6 . Positive_regulation TNF CD79A 18496506 1965450 The activation of NF kappaB and [TNF-alpha] synthesis *induced* by polymeric or TNF-alpha were downregulated by BMP-7 or rosiglitazone . Positive_regulation TNF CD79A 18496506 1965456 Our study shows that BMP-7 ameliorates IgA nephropathy derived polymeric *induced* [TNF-alpha] and TGF-beta synthesis in human mesangial cells through multiple mechanisms involving inhibitory Smads and PPAR-gamma . Positive_regulation TNF CD79A 19340088 2080762 Further , when we tested the effects of the macromolecular IgA1 on human mesangial cells in culture , we found that the macromolecular taken from familial clusters had enhanced binding to mesangial cells and *caused* increased expression of interleukin-6 , [tumor necrosis factor-alpha] , and monocyte chemotactic peptide-1 . Positive_regulation TNF CD79A 19568710 2104587 The level of CD3 ( + ) , CD4 ( + ) , the ratio of CD4 and CD8 ( + ) , , IgM , IgG and IL-2 decreased in patients with NSCLC on day 1 after operation , and the level of CD8 and [TNF-alpha] *increased* compared to pre-operation . Positive_regulation TNF CD79A 2010162 154947 *triggers* [tumor necrosis factor] alpha secretion by monocytes : a study in normal subjects and patients with alcoholic cirrhosis . Positive_regulation TNF CD79A 2010162 154948 Polymeric *induces* [tumor necrosis factor] alpha secretion in a dose dependent fashion . Positive_regulation TNF CD79A 8262556 239179 The presence of containing immune complexes in monocyte monolayers *resulted* in a dose dependent increase of [TNF] production . Positive_regulation TNF CD79A 8262556 239180 The presence of monomeric or IgG did not *increase* [TNF] secretion . Positive_regulation TNF CD79A 9343748 459040 *caused* less production of [TNF alpha] when compared to IgG2 , but similar levels of IL-8 . Positive_regulation TNF CD80 10384156 624808 Neither IFN-gamma plus [TNF-alpha] nor CD40 stimulation significantly *induced* or up-regulated B7-2 on human myeloma cell line or primary myeloma cells from six of seven patients . Positive_regulation TNF CD80 17142787 1653777 The expression of and PD ligand-1 on monocytes could be *induced* in vitro by IFN-gamma and [TNF-alpha] that were produced abundantly in RA-derived synovial fluid ( SF ) . Positive_regulation TNF CD80 23246902 2737182 We found that RGP up-regulated the expression of CD40 , , CD83 , CD86 and MHC II molecules of BMDCs , down-regulated pinocytosis and phagocytosis activity , *induced* IL-12 and [TNF-a] production of BMDCs . Positive_regulation TNF CD80 23867288 2835179 We elucidated that IFN-? up-regulated the expression of MHC II , CD40 , , CD83 and CD86 molecules on BMDCs , down-regulated the activity of pinocytosis and phagocytosis by BMDCs , and *induced* higher levels of IL-12 and [TNF-a] secreted by BMDCs . Positive_regulation TNF CD80 24157331 2875307 Cry1Ac protoxin from Bacillus thuringiensis promotes macrophage activation by upregulating and CD86 and by *inducing* IL-6 , MCP-1 and [TNF-a] cytokines . Positive_regulation TNF CD80 8746558 344052 Likewise , the NOD derived NIT-1 beta cell line did not express surface B7 or B7-1 mRNA either constitutively or following exposure to IFN-gamma and [TNF-alpha] , two cytokines known to be present in the insulitis lesion of NOD mice , or cAMP which can *induce* expression on B cells . Positive_regulation TNF CD80 8816390 383596 Large amounts of IL-2 , IFN-gamma , and [TNF] were produced in addition to an increase in IL-2 mRNA as a *result* of costimulation . Positive_regulation TNF CD83 10201904 605652 [TNF-alpha] *induced* the cluster formation of the cells and the enhancement of cell surface expression levels of , CD86 , and HLA-DR , and T cell stimulatory capacity , whereas the capacities for the endocytosis and the chemotactic migration were suppressed in these cells . Positive_regulation TNF CD83 15454113 1301133 Phosphatidic acid and [tumor necrosis factor-alpha] *induce* the expression of through mitogen activated protein kinase pathway in a CD34+ hematopoietic progenitor cell line , KG1 . Positive_regulation TNF CD83 15454113 1301141 These results suggest that PA and [TNF-alpha] *induce* the up-regulation of and that their action is regulated by ERK and JNK . Positive_regulation TNF CD83 23867288 2835180 We elucidated that IFN-? up-regulated the expression of MHC II , CD40 , CD80 , and CD86 molecules on BMDCs , down-regulated the activity of pinocytosis and phagocytosis by BMDCs , and *induced* higher levels of IL-12 and [TNF-a] secreted by BMDCs . Positive_regulation TNF CD84 20628063 2321886 Concomitantly , the presence of *increased* the LPS induced secretion of [TNF-a] and MCP-1 but lowered IL-10 and IL-6 production significantly . Positive_regulation TNF CD86 10201904 605653 [TNF-alpha] *induced* the cluster formation of the cells and the enhancement of cell surface expression levels of CD83 , , and HLA-DR , and T cell stimulatory capacity , whereas the capacities for the endocytosis and the chemotactic migration were suppressed in these cells . Positive_regulation TNF CD86 12233883 988785 Interferon-gamma (IFN-gamma) induced the cultured salivary gland epithelial cells to express HLA class I antigens , HLA-DR antigens , CD80 , and ICAM-1 , while [tumor necrosis factor-alpha (TNF-alpha)] *induced* the expression of HLA class I antigens , CD80 , , and VCAM . Positive_regulation TNF CD86 19384869 2069203 Stimulation of BM CD20 ( + ) B cells by CpG containing oligodeoxynucleotide enhanced expression of activation markers ( and CD54 ) *triggered* IL-6 and [TNF-alpha] secretion and cell proliferation . Positive_regulation TNF CD86 23246902 2737183 We found that RGP up-regulated the expression of CD40 , CD80 , CD83 , and MHC II molecules of BMDCs , down-regulated pinocytosis and phagocytosis activity , *induced* IL-12 and [TNF-a] production of BMDCs . Positive_regulation TNF CD86 23867288 2835181 We elucidated that IFN-? up-regulated the expression of MHC II , CD40 , CD80 , CD83 and molecules on BMDCs , down-regulated the activity of pinocytosis and phagocytosis by BMDCs , and *induced* higher levels of IL-12 and [TNF-a] secreted by BMDCs . Positive_regulation TNF CD86 24157331 2875308 Cry1Ac protoxin from Bacillus thuringiensis promotes macrophage activation by upregulating CD80 and and by *inducing* IL-6 , MCP-1 and [TNF-a] cytokines . Positive_regulation TNF CD8A 1347307 179217 I . Transforming growth factor-beta and [tumor necrosis factor-alpha] *induce* expression on CD8- thymic subsets including the CD25+CD3-CD4-CD8- pre-T cell subset . Positive_regulation TNF CD8A 1347307 179222 Of 15 cytokines tested , only transforming growth factor ( TGF-beta ) and [TNF-alpha] *induced* ( Lyt-2 ) , while no cytokine was able to induce CD4 on CD25+CD3-CD4-CD8- thymocytes . Positive_regulation TNF CD8A 1347307 179226 In contrast , neither TGF-beta nor [TNF-alpha] *induced* expression on splenic CD4+CD8- T cells . Positive_regulation TNF CD8A 14634144 1170927 The increase in IL-5 was primarily due to an increase in CD4 ( + ) and CD8 ( + ) T cells , the increase in IL-10 was primarily due to an increase in CD64 ( + ) monocytes/macrophages with some effect in T cells , while the decrease in [TNF-alpha] was primarily *due* to a decrease in ( + ) T cells . Positive_regulation TNF CD8A 15162447 1253053 Furthermore , we found that the interaction of SEB stimulated ( + ) CTL with lung epithelial cells induced an *increase* in [TNF-alpha] secretion . Positive_regulation TNF CD8A 16114098 1454326 The engagement of or activating KIR also *triggered* the production of [TNF-alpha] . Positive_regulation TNF CD8A 16955143 1611100 While TLR3 activation did not directly alter liver-specific T cell function , it *induced* IFN-alpha and [TNF-alpha] release . Positive_regulation TNF CD8A 17187430 1679983 While TLR3 activation did not directly alter liver-specific T cell function , it *induced* IFN-alpha and [TNF-alpha] release . Positive_regulation TNF CD8A 17296788 1698836 We show that dyslipidemia inhibited Toll-like receptor (TLR) induced production of proinflammatory cytokines , including interleukin (IL)-12 , IL-6 , and [tumor necrosis factor-alpha] , as well as *up-regulation* of costimulatory molecules by CD8alpha ( - ) DCs , but not by ( + ) DCs , in vivo . Positive_regulation TNF CD8A 21038470 2339068 The induction of ( + ) Treg by anti-CD3 mAb *requires* [TNF] and signaling through the NF-?B cascade . Positive_regulation TNF CD8A 24080983 2863359 Further study demonstrated that Schwann cells promoted activation of ( + ) T cells and induced expression of [TNF-a] , FasL , and PDL1 on CD8 ( + ) T cells , in return , CD8 ( + ) T cells *induced* obvious apoptosis of Schwann cells . Positive_regulation TNF CD8B 1347307 179223 Of 15 cytokines tested , only transforming growth factor ( TGF-beta ) and [TNF-alpha] *induced* ( Lyt-2 ) , while no cytokine was able to induce CD4 on CD25+CD3-CD4-CD8- thymocytes . Positive_regulation TNF CD8B 1347307 179227 In contrast , neither TGF-beta nor [TNF-alpha] *induced* expression on splenic CD4+CD8- T cells . Positive_regulation TNF CD8B 15162447 1253054 Furthermore , we found that the interaction of SEB stimulated ( + ) CTL with lung epithelial cells induced an *increase* in [TNF-alpha] secretion . Positive_regulation TNF CD8B 16955143 1611101 While TLR3 activation did not directly alter liver-specific T cell function , it *induced* IFN-alpha and [TNF-alpha] release . Positive_regulation TNF CD8B 17187430 1679984 While TLR3 activation did not directly alter liver-specific T cell function , it *induced* IFN-alpha and [TNF-alpha] release . Positive_regulation TNF CD8B 17296788 1698837 We show that dyslipidemia inhibited Toll-like receptor (TLR) induced production of proinflammatory cytokines , including interleukin (IL)-12 , IL-6 , and [tumor necrosis factor-alpha] , as well as *up-regulation* of costimulatory molecules by CD8alpha ( - ) DCs , but not by ( + ) DCs , in vivo . Positive_regulation TNF CD8B 21038470 2339069 The induction of ( + ) Treg by anti-CD3 mAb *requires* [TNF] and signaling through the NF-?B cascade . Positive_regulation TNF CD8B 24080983 2863360 Further study demonstrated that Schwann cells promoted activation of ( + ) T cells and induced expression of [TNF-a] , FasL , and PDL1 on CD8 ( + ) T cells , in return , CD8 ( + ) T cells *induced* obvious apoptosis of Schwann cells . Positive_regulation TNF CDA 10540334 563378 In these cells a modest but significant *induction* of [TNF-alpha] release by was also detected . Positive_regulation TNF CDC42 17018860 1682932 In the resting cell , RhoA suppresses activation , IkappaBalpha degradation , nuclear factor-kappaB (NF-kappaB) activation , and *induction* of [TNFalpha] and NF-kappaB dependent chemokines . Positive_regulation TNF CDC42 17018860 1682938 Suppression of TNFalpha induction by RhoA is Rho kinase alpha ( ROCKalpha ) independent , but Cdc42 dependent , because [TNFalpha] induction by C3 transferase is *attenuated* by inhibition of , and constitutively active Cdc42 suffices to activate NF-kappaB and induce TNFalpha . Positive_regulation TNF CDC42 17018860 1682944 By contrast , we also place RhoA downstream of p38 mitogen activated protein kinase and Cdc42 in a novel LPS activated pathway in which p38 , , and ROCKalpha all *promote* [TNFalpha] protein expression . Positive_regulation TNF CDC73 10422778 632386 However , exogenously added up to 100 nM did not *stimulate* production of [tumor necrosis factor-alpha] . Positive_regulation TNF CDC73 10435033 634209 [TNF-alpha] in the *presence* of WEB 2170 or CV 3988 , or was studied with the Greiss reagent method . Positive_regulation TNF CDC73 10921504 717352 antioxidants significantly inhibited both the in vivo and in vitro *induced* NF-kappaB activation and NF-kappaB dependent [TNF-alpha] expression . Positive_regulation TNF CDC73 15316260 1286190 The aim of this study was to determine [tumor necrosis factor alpha (TNF-alpha)] and interleukin-6 (IL-6) release in *response* to induction in peripheral blood mononuclear cells ( PBMCs ) from chronic hepatitis B virus ( HBV ) carriers . Positive_regulation TNF CDC73 15316260 1286210 Compared with group A , PBMCs from naturally immune subjects and chronic HBV carriers produced significantly higher amounts of [TNF-alpha] and IL-6 in *response* to . Positive_regulation TNF CDC73 15702351 1382758 Finally , up to 2 mug/ml , did not *induce* the production of pro-inflammatory cytokines such as IL-6 , IL-8 , and [TNF-alpha] . Positive_regulation TNF CDC73 1613396 191103 can *augment* [tumor necrosis factor (TNF)] production by human monocytes in a bimodal manner , with two peaks of activation at picomolar and micromolar concentrations . Positive_regulation TNF CDC73 1613396 191108 Moreover , 6 day- or 7 day differentiated HL-60 cells showed a further increase in [TNF] production in *response* to , and the response was bimodal , similar to that of the less dense subset of monocytes , with peaks at 10 ( -14 ) and 10 ( -7 ) M PAF . Positive_regulation TNF CDC73 1668105 176682 *induced* maximal [TNF alpha] synthesis 2-3 hr after monocyte stimulation as assessed by dot blotting of cell associated TNF alpha using polyclonal anti-TNF antibody . Positive_regulation TNF CDC73 16829183 1591444 Both [TNF-alpha] and IL-1beta induced HUVEC platelet activating factor (PAF) production and was *required* for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine ) . Positive_regulation TNF CDC73 17881124 1802337 The data indicate that these three biochemically unrelated classes of inflammatory repressors act synergistically in modulating *induced* up-regulation of COX-2 , [TNFalpha] , and PGE ( 2 ) by quenching oxidative stress or inflammatory signaling , resulting in increased HN cell survival . Positive_regulation TNF CDC73 1873355 165240 Further , the *role* of released in response to a challenge with LPS in the regulation of [TNF] and IL-6 production was investigated . Positive_regulation TNF CDC73 19769579 2258179 Our previous studies have demonstrated that UVB mediated production of keratinocyte [TNF-alpha] is in part *due* to . Positive_regulation TNF CDC73 20116443 2258829 An immediate low release of PGE ( 2 ) was *induced* by PAF , phorbol ester and arachidonic acid but not by IL1beta , [TNF-alpha] and LPS whereas a delayed high release of PGE ( 2 ) was induced by the inflammatory agents IL1beta , TNF-alpha and LPS but not by , phorbol ester and arachidonic acid . Positive_regulation TNF CDC73 20187806 2216113 However , did not *stimulate* the generation of IL-6 , IL-8 , [TNF-alpha] , and MMP-1 to any significant level and in a consistent manner . Positive_regulation TNF CDC73 20423922 2437231 In rats , [TNF-a] increased hydraulic conductivity 2.5-fold over baseline and *increased* it 5-fold ; Positive_regulation TNF CDC73 2133285 150723 Secretion of [TNF] was *detected* shortly after addition of and was dependent on the PAF concentration used . Positive_regulation TNF CDC73 2133285 150728 While biologically active and cytotoxic [TNF] was *detected* early after addition of , the cytotoxic activity declined thereafter though the antigenic activity remained constant . Positive_regulation TNF CDC73 2133286 150733 We have recently shown that can markedly *enhance* the production of [tumor necrosis factor (TNF)] and interleukin-1 (IL-1) by human monocytes stimulated with lipopolysaccharide or muramyl dipeptide ( MDP ) . Positive_regulation TNF CDC73 2230235 144607 The decrease in plasma [TNF alpha] *induced* by or alprazolam was partly reversed by indomethacin . Positive_regulation TNF CDC73 2266661 147294 Inhibitors of PAF synthesis , such as plasma alpha 1-proteinase inhibitor and an anti-inflammatory peptide , blocked changes induced by TNF , PAF receptor antagonists inhibited changes *induced* by and also by [TNF] . Positive_regulation TNF CDC73 2329280 132457 increased cell associated TNF maximally after 2 to 3 h of incubation and *increased* [TNF] release maximally after 5 to 18 h of incubation . Positive_regulation TNF CDC73 2545780 114294 *enhances* [tumor necrosis factor] production by alveolar macrophages . Positive_regulation TNF CDC73 2545780 114304 *Stimulation* of [TNF] production by was blocked by specific , but structurally different PAF receptor antagonists , BN 52021 , CV3988 and WEB 2086 . Positive_regulation TNF CDC73 2545780 114309 Inhibition of 5-lipoxygenase by nordihydro-guaiaretic acid or AA-861 blocked the *induced* augmentation of both [TNF] and LTB4 production . Positive_regulation TNF CDC73 2545780 114321 Collectively , these data suggest that *enhances* [TNF] production by interaction with a specific putative receptor and by subsequent induction of endogenous 5-lipoxygenase activity in AM . Positive_regulation TNF CDC73 7634340 317035 In addition , significantly *enhanced* LPS induced [TNF alpha] production . Positive_regulation TNF CDC73 7683748 216565 It has also been reported , that murine TNF stimulates the production of platelet activating factor (PAF) by cultured peritoneal macrophages , and that *enhances* [TNF] production by alveolar macrophages . Positive_regulation TNF CDC73 7821968 285547 We have shown previously that endotoxin , tumour necrosis factor (TNF) and platelet activating factor (PAF) are important in the pathogenesis of bowel injury , and that endotoxin and [TNF] *induce* formation in bowel tissue . Positive_regulation TNF CDC73 7895533 299756 also *caused* elevated serum [TNF-alpha] in some control mice but not in C3H/HeJ mice . Positive_regulation TNF CDC73 7930608 274728 Despite increasing RNA for the TNF-alpha gene , *increases* [TNF-alpha] protein levels only in the presence of a costimulus , such as PMA . Positive_regulation TNF CDC73 7930608 274733 We also report that *enhances* PMA induced [TNF-alpha] production from human peripheral B cells . Positive_regulation TNF CDC73 8045673 266904 ET-18-O-OCH3 and *stimulated* [TNF alpha] release by resident BALB/c macrophages in the presence of LPS but not in the absence of this co-factor . Positive_regulation TNF CDC73 8045673 266909 In contrast , both ET-18-O_OCH3 and *stimulated* [TNF alpha] release by thioglycollate elicited macrophages in the absence of LPS although release was greater in the presence of this co-stimulus . Positive_regulation TNF CDC73 8080039 270812 Interleukin-1 beta and [tumor necrosis factor-alpha] *induce* production by endothelium , and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist . Positive_regulation TNF CDC73 8088357 271458 Furthermore , [TNF] production *induced* by itself in vitro was also inhibited in the presence of FR128998 . Positive_regulation TNF CDC73 8514698 221950 Repeated dosing also *resulted* in sustained increased serum [tumor necrosis factor-alpha] levels ( 1,610 +/- 470 pg/ml , P < 0.01 ) and further exacerbation of the leukopenia ( -68 +/- 6 % , P < 0.01 ) and thrombocytopenia ( -65 +/- 8 % , P < 0.01 ) . Positive_regulation TNF CDC73 8704099 371129 We have assessed whether *stimulates* IL-6 and [TNF-alpha] production by human bone marrow stromal cells ( mostly fibroblast-like cells ) . Positive_regulation TNF CDC73 9249487 446827 and 2 ) endogenous [TNF-alpha] is not required for LPS mediated induction of iNOS mRNA , and *mediates* LPS induced APH . Positive_regulation TNF CDC73 9394802 468189 These data suggest that , which is released immediately or shortly after LPS injection , *induces* the expression of [TNF-alpha] through the activation of NF-kappa B . Positive_regulation TNF CDH5 16891393 1638884 [TNF-alpha] *increases* tyrosine phosphorylation of and opens the paracellular pathway through fyn activation in human lung endothelia . Positive_regulation TNF CDK1 8262134 239134 We observed that [TNF] *induced* and CDK2 expression in early-passage quiescent WI-38 fibroblasts . Positive_regulation TNF CDK19 14982858 1214502 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF CDK19 18675993 2011394 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF CDK19 3292408 94721 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF CDK2 12761882 1091732 We show that [TNF] *induces* p21 ( waf1 ) protein in malignant melanoma A375 cells and its binding to and 6 proteins , and thereby inhibiting the activity of these complexes . Positive_regulation TNF CDK2 8262134 239135 We observed that [TNF] *induced* CDC2 and expression in early-passage quiescent WI-38 fibroblasts . Positive_regulation TNF CDK8 14982858 1214500 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF CDK8 18675993 2011392 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF CDK8 3292408 94719 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF CDK9 15879558 1406185 Disruption of function by the Cdk-inhibitor , DRB , or by small interfering RNA selectively *blocked* [TNFalpha] stimulation of IL-8 mRNA production . Positive_regulation TNF CDK9 17675290 1794074 By electrophoretic mobility shift assay analyses , [TNF-alpha] and lipopolysaccharide *induce* strong p65/p50 and p65/c-Rel binding to both NF-kappaB and TF-kappaB probes . Positive_regulation TNF CDKN1A 11097743 755791 [TNF-alpha] *induced* expression of ( WAF1 ) at protein and mRNA levels in a dose dependent fashion with an association with G ( 1 ) -arrest in human colon cancer cells WiDr that carry mutated p53 at codon 273 ( His ( 273 ) ) . Positive_regulation TNF CDKN1A 11097743 755795 These findings suggest that [TNF-alpha] *induces* expression of ( WAF1 ) through a distinct pathway from Bax and that protein stabilization is an important mechanism in the expression of p21 ( WAF1 ) independent of p53 . Positive_regulation TNF CDKN1A 11973611 934352 In MCF-7 cells , [TNF alpha] *induces* a G1 arrest with an increased expression of , an activation of NF-kappa B and an accumulation of p53 . Positive_regulation TNF CDKN1A 15326480 1296847 The present study described that , in the leukemic KG1 cells , [TNFalpha] *induced* no apoptosis but a senescence state characterized by prolonged growth arrest , increased beta-galactosidase activity , induction , decreased telomerase activity , telomeric disturbances ( shortening , losses , fusions ) , and additional chromosomal aberrations . Positive_regulation TNF CDKN1A 16216243 1476494 [TNF-alpha] *induced* increases in expression resulting in partial cell cycle attenuation in the G1 phase . Positive_regulation TNF CDS1 9115637 423509 This increase in activity also *leads* to increased secretion of [tumor necrosis factor-alpha] and interleukin-6 from endothelial ECV304 cells upon stimulation with interleukin-1beta , suggesting that CDS overexpression may amplify cellular signaling responses from cytokines . Positive_regulation TNF CDS2 9115637 423510 This increase in activity also *leads* to increased secretion of [tumor necrosis factor-alpha] and interleukin-6 from endothelial ECV304 cells upon stimulation with interleukin-1beta , suggesting that CDS overexpression may amplify cellular signaling responses from cytokines . Positive_regulation TNF CDX2 18507686 1958430 [TNF-alpha] *induced* the expression of and MUC2 in cultured BEC . Positive_regulation TNF CEACAM1 21329777 2453117 Our results demonstrated that strongly *induced* the secretion of [TNF-a] , IL-6 , IL-10 and IL-12 ; Positive_regulation TNF CEACAM5 11125277 769045 In contrast , significantly *increased* the production of IL-6 ( p < 0.001 ) and [TNF-alpha] ( p = 0.002 ) , while PSA significantly decreased IL-1beta ( p < 0.001 ) , IL-6 ( p = 0.031 ) and TNF-alpha ( p < 0.0001 ) production . Positive_regulation TNF CEACAM5 12969251 1139142 , used as model AGE , *induces* nitric oxide ( NO ) , [TNF-alpha] and IL-6 production . Positive_regulation TNF CEACAM5 21901530 2501381 In the liver binds with hnRNP M on Kupffer cells and *causes* activation and production of pro- and anti-inflammatory cytokines including IL-1 , IL-10 , IL-6 and [TNF-a] . Positive_regulation TNF CEACAM5 9310253 454814 Results demonstrate that *induced* IL-1alpha and [TNF-alpha] production involves tyrosine phosphorylation and the signaling in CEA treated cells is different than that seen with LPS stimulation . Positive_regulation TNF CEBPA 9916895 559054 We determined that binding sites for both NF-kappaB ( -186 bp region ) and ( -198 bp region ) are *involved* in [TNF-alpha] and IL-1beta mediated ICAM-1 upregulation . Positive_regulation TNF CEBPB 10594926 655131 Here we show that lipopolysaccharides (LPS) , IL-1beta , and [TNFalpha] *induce* the expression of the and -delta genes in mouse primary astrocytes . Positive_regulation TNF CEBPB 10930293 719776 These observations demonstrate that , and c-Jun *contribute* to the regulation of the [TNF-alpha] gene in normal macrophages following treatment with PMA . Positive_regulation TNF CEBPB 11456275 838130 In fully differentiated adipocytes , [TNF-alpha] rapidly *induced* and C/EBPdelta , whereas it downregulated the expression of C/EBPalpha and PPARgamma . Positive_regulation TNF CEBPB 14514692 1164957 The [tumor necrosis factor] alpha dependent activation of the human mediterranean fever (MEFV) promoter is *mediated* by a synergistic interaction between and NF kappaB p65 . Positive_regulation TNF CEBPB 16850160 1607153 *regulates* [TNF] induced MnSOD expression and protection against apoptosis . Positive_regulation TNF CEBPB 18040799 1669150 Similarly , [TNF-alpha] *induced* the activation of and the expression of BDNF was sensitive to overexpression of DeltaC/EBPbeta ( a dominant negative mutant ) and ETO ( an inhibitor of C/EBPbeta ) . Positive_regulation TNF CEBPB 19353522 2064837 We further found that , while either IFNgamma or [TNFalpha] alone *induced* minor expression of in MSCs , this transcription factor was dramatically upregulated when these cytokines were added together . Positive_regulation TNF CEBPB 19530226 2109521 Binding of the NF kappaB p65 subunit and to this element is *induced* by [TNF alpha] . Positive_regulation TNF CEBPB 7929820 274666 We present data to show that the expression of [TNF alpha] is *regulated* by the transcription factor ( NF-IL6 ) . Positive_regulation TNF CEBPB 7929820 274671 *activated* the [TNF alpha] gene promoter in cotransfection assays and bound to it at a site which failed to bind the closely related protein C/EBP alpha . Positive_regulation TNF CEBPD 11456275 838131 In fully differentiated adipocytes , [TNF-alpha] rapidly *induced* C/EBPbeta and , whereas it downregulated the expression of C/EBPalpha and PPARgamma . Positive_regulation TNF CEBPD 21715338 2465906 mediates [tumor necrosis factor] alpha *induced* Aurora kinase C transcription and promotes genomic instability . Positive_regulation TNF CEBPD 9350999 460915 RT-PCR failed to detect the IL-1 transcript in TNFalpha treated HepG2 cells , suggesting that *activation* of by [TNFalpha] is not related to the IL-1 signalling pathway . Positive_regulation TNF CEBPZ 20823568 2318503 After the onset of heat stroke , the heat stroke rats display decreased MAP , decreased , *increased* the plasma levels of [TNF-alpha] , increased cerebral striatal monoamines and hydroxyl radical production release , and severe cerebral ischemia and neuronal damage compared with those of normothermic control rats . Positive_regulation TNF CEL 15069018 1265670 Using a lethally irradiated parent -- > F1 mouse IPS model , we showed that 5 weeks after transplantation allo-BMT recipients developed significant lung injury compared with syngeneic controls , which was associated with increased fluid levels of TNF-alpha , elevated numbers of donor derived TNF-alpha secreting T cells , and *increased* pulmonary macrophage production of [TNF-alpha] to lipopolysaccharide (LPS) stimulation . Positive_regulation TNF CEL 17846063 1823050 , an invertebrate N-acetylgalactosamine-specific C-type lectin , *induces* [TNF-alpha] and G-CSF production by mouse macrophage cell line RAW264.7 cells . Positive_regulation TNF CEL 17846063 1823054 In this study , we found that *induced* increased secretion of [tumour necrosis factor-alpha (TNF-alpha)] and granulocyte colony stimulation factor ( G-CSF ) by mouse macrophage cell line RAW264.7 cells in a dose dependent manner , whereas this cell line was highly resistant to CEL-I cytotoxicity . Positive_regulation TNF CEMP1 11038318 741647 stimulation also *induced* [TNF-alpha] , IL-2 , and IL-5 mRNA production by spleen cells from infected animals . Positive_regulation TNF CERK 22009748 2516464 *regulates* the production of [tumor necrosis factor a (TNFa)] via inhibition of TNFa converting enzyme . Positive_regulation TNF CERS6 22544924 2602957 Downregulation of by RNA interference or endogenous upregulation of C ( 16 : 0 ) -Cer mediated by palmitic acid in RAW 264.7 macrophages *led* to a significant reduction or increase in [NO/TNF-a] release , respectively . Positive_regulation TNF CFB 22326848 2580631 In contrast , [TNF-a] *induced* gene expression was not deficient in MyD88 ( -/- ) cardiomyocytes . Positive_regulation TNF CFP 16857767 1600440 Using isolated ATII-cells , it was studied whether prevent C. pneumoniae *induced* [TNF-alpha] and MIP-2 release and what the underlying pathway is . Positive_regulation TNF CFP 22192908 2549555 Meanwhile , several studies showed that and ESAT6 could inhibit and/or *promote* the production of [tumor necrosis factor a (TNF-a)] from macrophages . Positive_regulation TNF CFTR 23626828 2779057 The mRNA and protein expression levels of in donor and recipient jejunal mucosae of mice were also markedly lower than those in controls ( P < 0.001 ) , and the mRNA and protein expression levels of [tumor necrosis factor a (TNFa)] were markedly *increased* in donor jejunal mucosae of mice ( P < 0.001 ) , compared with controls . Positive_regulation TNF CGA 10929074 719687 In contrast , rutin and *augmented* the inducible cytokine messages , i.e . interleukin (IL)-10 , IL-13 , interferon-gamma (IFN-gamma) , IL-6 and [tumour necrosis factor-alpha (TNF-alpha)] in IgE sensitized mast cells following antigen challenge . Positive_regulation TNF CGA 15342341 1353762 *stimulates* microglial secretion of NO and [TNFalpha] , resulting in both neuronal and microglial apoptosis . Positive_regulation TNF CGA 15342341 1353763 We compared the potency of CGA with that of beta-amyloid ( betaA ) under identical conditions and found that *induces* 5-7 times greater NO and [TNFalpha] secretion . Positive_regulation TNF CGA 9603942 507057 also *induced* a marked accumulation of nitric oxide and [tumor necrosis factor-alpha] by microglia , but we could not establish a direct correlation between the levels of nitric oxide and tumor necrosis factor-alpha and the neuronal damage . Positive_regulation TNF CGN 20937806 2353618 [TNF-a] induced the ubiquitination of TRAF2 ( TNF receptor associated factor 2 ) , which interacts with NIK , and *induced* phosphorylation of BCL10 , leading to increased NIK phosphorylation . Positive_regulation TNF CGN 24126493 2858871 This study indicated that *induced* [TNF-a] secretion is the main contributor to cellular damage in Caco-2 monolayers exposed to ?-CGN . Positive_regulation TNF CHDH 9781629 540543 We conclude that in vitro adipocyte IS is reduced and adipocyte [TNF-alpha] production is *increased* in premenopausal women with . Positive_regulation TNF CHGA 21462331 2412863 This study also showed that [tumor necrosis factor a (TNF-a)] *induced* mRNA expression in HT-29 human colon cancer cells , and vitamin B6 ( pyridoxal hydrochloride ) pretreatment of HT-29 cells inhibited TNF -induced mRNA expression of SPI-3 . Positive_regulation TNF CHI3L1 21763261 2466931 Purified efficiently activated the NF-?B signaling pathway and *enhanced* the secretion of IL-8 and [TNF-a] in SW480 human colon cancer cells . Positive_regulation TNF CHST2 15728736 1416820 Expression of N-acetylglucosamine 6-O-sulfotransferases ( GlcNAc6STs ) -1 and -4 in human monocytes : is implicated in the generation of the 6-sulfo N-acetyllactosamine/Lewis x epitope on CD44 and is *induced* by [TNF-alpha] . Positive_regulation TNF CHST2 15728736 1416822 However , only was *induced* by [TNF-alpha] in the human SR91 cell line , which also up-regulated the AG107 epitope . Positive_regulation TNF CHUK 10195894 603959 In mammalian cells , phosphorylation of two sites at the activation loop of IKKbeta was essential for *activation* of by [tumor necrosis factor] and interleukin-1 . Positive_regulation TNF CHUK 10744744 680749 MG-132 , a specific proteasome inhibitor , abrogated GA-induced degradation of RIP but failed to restore the *activation* of by [TNF] , perhaps because , in the presence of GA and MG-132 , RIP accumulated in a detergent-insoluble subcellular fraction . Positive_regulation TNF CHUK 11124824 768960 We analyzed the differential *role* of and I kappa B kinase 2 (IKK2) in [tumor necrosis factor alpha (TNF-alpha)-] and interleukin-1 beta (IL-1 beta) mediated NF-kappa B activation in primary rat hepatocytes . Positive_regulation TNF CHUK 11280761 798769 However , although [TNF-alpha] *induced* rapid activation of as expected , this activity was substantially reduced in the presence of VEGF . Positive_regulation TNF CHUK 11356844 834441 The present study shows that PTEN , a tumor suppressor that inhibits PI 3-kinase function , impairs [TNF] *activation* of Akt and the in 293 cells . Positive_regulation TNF CHUK 11479295 860522 Since oxidants have been implicated in the regulation of NF-kappaB , the focus of the present study was the *activation* of by [tumor necrosis factor alpha (TNFalpha)] in the presence or absence of hydrogen peroxide ( H ( 2 ) O ( 2 ) ) . Positive_regulation TNF CHUK 11479295 860540 In contrast , [TNFalpha] *induced* activity rapidly and transiently resulting in IkappaBalpha degradation and NF-kappaB activation . Positive_regulation TNF CHUK 12181188 977492 In conclusion , Fe2+ serves as a direct agonist to activate , NF-kappaB , and TNF-alpha promoter activity and to *induce* the release of [TNF-alpha] protein by cultured Kupffer cells in a redox status dependent manner . Positive_regulation TNF CHUK 12482991 1032860 Experiments with IKK1 ( -/- ) and IKK2 ( -/- ) double knockout embryonic fibroblasts demonstrate that the is *essential* for [TNF-alpha] to stimulate phosphorylation on p105 serines 927 and 932 . Positive_regulation TNF CHUK 12847684 1109023 To investigate the potential *role* of and IKK-2 in the regulation of nuclear factor kappaB (NF-kappaB) activation and the expression of [tumor necrosis factor alpha (TNFalpha)] , as well as interleukin-1beta (IL-1beta) , IL-6 , IL-8 , vascular endothelial growth factor ( VEGF ) , and matrix metalloproteinases ( MMPs ) , in rheumatoid arthritis ( RA ) . Positive_regulation TNF CHUK 12867425 1141838 A role for NF-kappaB essential modifier/IkappaB kinase-gamma ( NEMO/IKKgamma ) ubiquitination in the *activation* of the by [tumor necrosis factor-alpha] . Positive_regulation TNF CHUK 12867425 1141854 Thus , the ubiquitination of NEMO mediated by c-IAP1 likely plays an important role in the *activation* of by [TNF-alpha] . Positive_regulation TNF CHUK 12934647 1132827 IL-1beta and [TNF-alpha] can *induce* extracellular signal regulated kinase ( ERK ) , , IkappaB degradation and NF-kappaB activation . Positive_regulation TNF CHUK 14764716 1207359 The *activation* of the complex by [TNF] or LPS stimulates phosphorylation and degradation of I-kappaBalpha , leading to the nuclear translocation of NF-kappaB . Positive_regulation TNF CHUK 15106733 1240533 [TNF-alpha] plus IFN-gamma can *induce* extracellular signal regulated kinase ( ERK ) , , IkappaB degradation and NF-kappaB activation . Positive_regulation TNF CHUK 15611276 1357381 The LPS triggered induction of [TNF-alpha] in monocytes is *dependent* on activity , as confirmed by IKK-specific antisense oligodeoxynucleotides . Positive_regulation TNF CHUK 15784689 1410067 Here , we demonstrated that inhibition of ( IKK ) by a peptide IKK inhibitor or by four individual chemical IKK inhibitors including 15-deoxy-prostaglandin J ( 2 ) , BMS-345541 , SC-514 , or sulindac significantly *blocked* IgE + trinitrophenyl (TNP) induced [TNF] production by mouse bone marrow derived MC ( BMMC ) . Positive_regulation TNF CHUK 16603398 1550695 *Activation* of by [TNFalpha] requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO . Positive_regulation TNF CHUK 16723255 1570414 In cells progressing through S-phase , [TNFalpha] *activation* of , JNK , and p38 is significantly reduced . Positive_regulation TNF CHUK 16774932 1672077 The use of Ro-318220 and GO-6983 , general PKC inhibitors as well as MG-132 , a proteasome-specific inhibitor , abrogated PMA induced degradation of IKK-gamma and recovered the *activation* of by [TNF] , suggesting that IKK complex is predominantly degraded by the proteasome pathway in a PKC dependent manner . Positive_regulation TNF CHUK 16806191 1580401 The protein kinase COT/Tpl2 is activated by interleukin-1 (IL-1) , [TNFalpha] and lipopolysaccharide , and its activation by these agonists *involves* the catalysed phosphorylation of the p105 regulatory subunit . Positive_regulation TNF CHUK 17495962 1791832 Bay 11-7085 , an inhibitor of , *reduced* [tumor necrosis factor-alpha (TNFalpha)] production from LPS stimulated XS52 cells and inhibited the ability of LC to present antigen to a T-cell clone in vitro . Positive_regulation TNF CHUK 19150425 2026745 The combined data reveal that phosphorylation of TRAF2 *plays* a critical role in [TNF] signaling by directing the to the membrane , promoting TRAF2 K63 linked ubiquitination , and positioning the IKKalpha and IKKbeta chains with the TAK1/TAB kinase . Positive_regulation TNF CHUK 21571356 2470229 PBMCs from control subjects were stimulated with [TNF-a] and cigarette smoke extract in the *presence* or absence of fluticasone propionate ( FP ) , L-glutathione reduced , or both , and activation and IL-8 release were evaluated . Positive_regulation TNF CHUK 24437486 2922604 After administration of a nonselective ß-adrenergic receptor blocker ( propranolol ) before induction of cerebral ischemic injury , hepatic adrenergic transduction , [TNF-a] expression , ER stress , and the *activation* of the JNK1/2 , , and NF-?B pathways , and serine phosphorylation of IRS-1 were all attenuated . Positive_regulation TNF CIITA 11675374 873209 We have demonstrated that IFN-gamma and [TNF-alpha] synergistically *induce* HLA-DRalpha and mRNAs , but prolonged incubation resulted in the inhibition of CIITA mRNA accumulation . Positive_regulation TNF CISH 11014223 736324 Although IL-1/beta and [TNFalpha] alone *induced* only weakly the expression of SOCS-3 and , these cytokines strongly potentiated the induction of these two SOCS by GH . Positive_regulation TNF CISH 12193734 981538 These findings suggest that a NF-kappaB binding site between -433 and -423 bp is *required* for [TNF-alpha] responsiveness and for TNF-alpha- and IFN-gamma stimulated synergistic responsiveness of the Bf gene . Positive_regulation TNF CISH 1431236 202872 in turn *causes* the local release of [TNF alpha] , which thwarts sensitization by its ability to alter the functional program of epidermal Langerhans cells , thereby preventing the induction of CH . Positive_regulation TNF CISH 1578133 187556 in turn *causes* the local release of [TNF-alpha] , which thwarts sensitization by its ability to trap epidermal Langerhans cells transiently within the epidermis , and thereby prevents the immunogenic signal from reaching the draining lymph node where activation of unprimed , Ag-specific T cells must occur . Positive_regulation TNF CISH 17118196 1652149 Stimulation of human PBMCs and purified T cells with ATRA and <9-cis-RA> *increased* mRNA and protein levels of IL-4 , IL-5 , and IL-13 and decreased levels of IFN-gamma , IL-2 , IL-12p70 and [TNF-alpha] upon activation with anti-CD3 and/or anti-CD28 mAbs . Positive_regulation TNF CISH 1858032 163869 Therefore , we hypothesized that , mitomycin-C , and doxorubicin hydrochloride ( Adriamycin ) , by the release of ROS , would *increase* macrophage [TNF] production . Positive_regulation TNF CISH 21798687 2472589 Linoleic acid and , trans-11 CLA isomer *had* no detectable effects on LPS induced [TNF-a] production in cultured bovine blood . Positive_regulation TNF CISH 23857174 2817046 Quantitative real time polymerase chain reaction analyses were performed to evaluate the expression of interleukin (IL)-4 , IL-10 , interferon ( IFN ) -? , [tumor necrosis factor (TNF)-a] and peroxisome proliferator activated receptor ( PPAR ) -? in *response* to and LA . Positive_regulation TNF CISH 24659790 2949100 Hepatitis C virus ( HCV ) -induced 3 *regulates* proinflammatory [TNF-a] responses . Positive_regulation TNF CKM 1611281 191043 *stimulated* thioglycollate induced peritoneal macrophages to produce interleukin 1 (IL-1) and [tumor necrosis factor alpha (TNF-alpha)] at concentrations of 1-100 ng/ml , and it also induced IL-2 and interferon-gamma (IFN-gamma) as well as IL-6 production by splenocytes . Positive_regulation TNF CLCN3 21071705 2376554 is *necessary* for the activation of SMCs by [TNF-a] but not thrombin . Positive_regulation TNF CLDN1 18949385 1978883 expression is *induced* by [tumor necrosis factor-alpha] in human pancreatic cancer cells . Positive_regulation TNF CLEC11A 22990857 2674426 The silencing of *results* in enhanced [TNF-a-] or IL-1 induced IKK activation , and an increased expression of genes encoding inflammatory mediators . Positive_regulation TNF CLEC5A 22005300 2503238 Triggering on these cells *induced* production of NO and [TNF-a] , which were found to be elevated in the serum of treated mice and required for MDL-1 induced shock . Positive_regulation TNF CLEC5A 22005300 2503240 Surprisingly , *induced* NO and [TNF-a] production required eNOS but not iNOS . Positive_regulation TNF CLEC7A 12719478 1086265 Here we show that *mediates* the production of [TNF-alpha] in response to zymosan and live fungal pathogens , an activity that occurs at the cell surface and requires the cytoplasmic tail and immunoreceptor tyrosine activation motif of Dectin-1 as well as Toll-like receptor (TLR)-2 and Myd88 . Positive_regulation TNF CLEC7A 16825490 1632057 A similar *requirement* for in [TNF-alpha] production was observed for macrophages infected with M bovis Bacillus Calmette-Guerin ( BCG ) , M phlei , M avium 2151-rough , and M tuberculosis H37Ra . Positive_regulation TNF CLEC7A 17227865 1689433 Production of proinflammatory [TNFalpha] by phagocytes was *suppressed* either by the presence of the alpha- ( 1,3 ) -glucan layer on yeast cells or by RNA interference based depletion of the host beta-glucan receptor . Positive_regulation TNF CLEC7A 18279049 1896387 Silencing of *resulted* in reduced expression of proinflammatory cytokines ( [tumor necrosis factor-alpha] and interleukin-12 ) , which was also reduced by anti-Dectin-1 antibody treatment prior to exposure to A. fumigatus , zymosan , or Candida albicans . Positive_regulation TNF CLEC7A 19124758 2019590 However , priming of bone marrow derived macrophages with GM-CSF or IFN-gamma permits *mediated* [TNF-alpha] induction . Positive_regulation TNF CLEC7A 19273561 2063322 The upregulation of [TNF-alpha] and downregulation of IL-12p70 *required* , but not IL-10 . Positive_regulation TNF CLEC7A 19410299 2128202 Zymosan *enhanced* dectin-1/TLR2/TLR4 expression and [TNF-alpha/IL-10] production in all of three types of cell , whereas p-beta-glucan increased and TNF-alpha/IL-12 production in AMs but inhibited IL-10 in mDCs . Positive_regulation TNF CLEC7A 19502385 2216576 However , *contributed* to the C. albicans stimulated increase in [TNF-alpha] production that occurred in GM-CSF primed macrophages . Positive_regulation TNF CLEC7A 21962774 2539426 Autoimmune regulator (AIRE) contributes to *induced* [TNF-a] production and complexes with caspase recruitment domain containing protein 9 ( CARD9 ) , spleen tyrosine kinase (Syk) , and Dectin-1 . Positive_regulation TNF CLEC7A 22028332 2574585 Subsequently , MD-Fraction induced GM-CSF enhanced proliferation and Dectin-1 expression , which permitted *mediated* [TNF-a] induction through the Syk pathway . Positive_regulation TNF CLPS 24069301 2847113 *increased* [TNF-a] . Positive_regulation TNF CLU 22166956 2549141 Moreover , differential comparison showed that CLU downregulation in RA led to a profound modification of the TNF-a response as three sets of genes emerged : 497 genes modulated by siCLU transfection with TNF stimulation , 356 genes modified because of TNF stimulation only , and 484 genes modulated during [TNF] *stimulation* with expression ( e.g. , IL-8 and Wnt signaling genes ) . Positive_regulation TNF CLU 22575505 2603606 *induces* the secretion of [TNF-a] and the chemotactic migration of macrophages . Positive_regulation TNF CLU 22575505 2603608 Here , we demonstrate that *upregulates* the expressions of chemotactic cytokines , that is , monocyte chemotactic protein-1 (MCP-1) , macrophage inflammatory protein-1ß ( MIP-1ß ) , regulated upon activation , normal T cell expressed and secreted ( RANTES ) , and [tumor necrosis factor-a (TNF-a)] in Raw264.7 macrophages . Positive_regulation TNF CLU 22575505 2603610 In particular , *stimulated* [TNF-a] secretion via the activations of ERK , JNK , and PI3K/Akt pathways in a time and dose dependent manner . Positive_regulation TNF CLU 22575505 2603611 Furthermore , *induced* [TNF-a] secretion was found to play a critical role in the chemotactic migration of Raw264.7 macrophages . Positive_regulation TNF CLU 9681829 521348 Stable transfection of a unresponsive mutated IkappaB-alpha Ser 32-36 expression vector showed that [TNF-alpha] *induced* MHC expression in an NF-kappaB dependent way while IFN-gamma did it independently of any NF-kappaB activation . Positive_regulation TNF CNR1 19047095 1999065 activation *induces* apoptosis through [tumor necrosis factor] alpha mediated ceramide de novo synthesis in colon cancer cells . Positive_regulation TNF CNR2 19047095 1999066 activation *induces* apoptosis through [tumor necrosis factor] alpha mediated ceramide de novo synthesis in colon cancer cells . Positive_regulation TNF CNTN2 12237295 1012359 *enhances* production of [tumor necrosis factor-alpha (TNF-alpha)] , which may lead to bone and joint destruction . Positive_regulation TNF CNTN2 12237295 1012361 *activated* the -1044 , -163 , and -125 [TNF-alpha] promoters by 9-25-fold but not the -82 promoter , demonstrating that Tax activation requires the -125 to -82 region , known as the TNF response element (TNF-RE) . Positive_regulation TNF CNTN2 12237295 1012363 Estradiol markedly repressed *activated* transcription of the [TNF-alpha] gene with estrogen receptor (ER) alpha or beta . Positive_regulation TNF CNTN2 14679154 1179079 , through its interactions with the TTP repressor , indirectly *increases* [TNF-alpha] expression . Positive_regulation TNF CNTN2 1527856 199972 In a cotransfection assay , the human T-cell leukemia virus type I gene product specifically *activated* transcription from the mouse [tumor necrosis factor] alpha promoter . Positive_regulation TNF CNTN2 15659397 1395300 However , it is also known that extracellular *induces* the production and release of cytokines , such as [tumor necrosis factor-alpha] and interleukin-6 , which have adverse effects on cells of the central nervous system . Positive_regulation TNF CNTN2 7979225 281277 ( 20 ng/ml ) *induced* [TNF-alpha] in microglia ( from undetectable or low basal levels to 215-1,075 pg/ml , mean 576 +/- 375 pg/ml , n = 4 ) and in PBMs ( 70-1,900 , mean 646 +/- 844 pg/ml , n = 4 ) . Positive_regulation TNF CNTN2 9178902 434273 Both APO ( S ) and APO ( R ) clones exhibited *dependent* upregulation of CD95 ligand and [TNF-alpha] . Positive_regulation TNF CNTN2 9261427 449047 Synthesis of [TNF-alpha] in *response* to soluble occurred in a dose dependent fashion between 0.25 and 75 nM and peaked within 6 h of treatment . Positive_regulation TNF CNTN2 9261427 449049 Interestingly , culturing NT2-N cells in the presence of soluble Tax1 for as little as 5 min was sufficient to result in TNF-alpha production , indicating that the induction of [TNF-alpha] in NT2-N does not *require* to be continually present in the culture medium . Positive_regulation TNF COA1 23433401 2755814 Although an synthetase inhibitor and ACSL1 siRNA both *suppressed* palmitate induced [tumor necrosis factor (TNF)-a] expression , the former had no effect on LPS induced TNF-a expression . Positive_regulation TNF COA3 23433401 2755816 Although an synthetase inhibitor and ACSL1 siRNA both *suppressed* palmitate induced [tumor necrosis factor (TNF)-a] expression , the former had no effect on LPS induced TNF-a expression . Positive_regulation TNF COA4 23433401 2755815 Although an synthetase inhibitor and ACSL1 siRNA both *suppressed* palmitate induced [tumor necrosis factor (TNF)-a] expression , the former had no effect on LPS induced TNF-a expression . Positive_regulation TNF COA5 23433401 2755817 Although an synthetase inhibitor and ACSL1 siRNA both *suppressed* palmitate induced [tumor necrosis factor (TNF)-a] expression , the former had no effect on LPS induced TNF-a expression . Positive_regulation TNF COA6 23433401 2755813 Although an synthetase inhibitor and ACSL1 siRNA both *suppressed* palmitate induced [tumor necrosis factor (TNF)-a] expression , the former had no effect on LPS induced TNF-a expression . Positive_regulation TNF COL1A1 18541003 1971985 In addition , the pro-inflammatory [tumor necrosis factor-alpha (TNF-alpha)] , produced in *response* to , increased MMP-9 production . Positive_regulation TNF COL1A1 21167013 2584837 AVE also markedly attenuated the increased mRNA expression of ( P < 0.001 ) and collagen III ( P < 0.001 ) and *inhibited* the overexpression of TGF-ß1 ( P < 0.05 ) and [TNF-a] ( P < 0.05 ) compared to the control group . Positive_regulation TNF COL1A1 23121981 2696235 *enhanced* the release of IL-12p40 , [TNF-a] and IFN-? by hDCs . Positive_regulation TNF COL1A1 7622181 315733 In addition , could also *induce* IL-1 , IL-6 and [TNF-alpha] in these samples from RA and OD patients but was less potent than type II collagen . Positive_regulation TNF COL1A2 18541003 1971986 In addition , the pro-inflammatory [tumor necrosis factor-alpha (TNF-alpha)] , produced in *response* to , increased MMP-9 production . Positive_regulation TNF COL1A2 21167013 2584838 AVE also markedly attenuated the increased mRNA expression of ( P < 0.001 ) and collagen III ( P < 0.001 ) and *inhibited* the overexpression of TGF-ß1 ( P < 0.05 ) and [TNF-a] ( P < 0.05 ) compared to the control group . Positive_regulation TNF COL1A2 23121981 2696236 *enhanced* the release of IL-12p40 , [TNF-a] and IFN-? by hDCs . Positive_regulation TNF COL1A2 7622181 315734 In addition , could also *induce* IL-1 , IL-6 and [TNF-alpha] in these samples from RA and OD patients but was less potent than type II collagen . Positive_regulation TNF COL2A1 7622181 315729 Similarly , *induced* IL-6 and [TNF-alpha] production rose significantly ( P < 0.01 ) from SF MNC of RA but less from OD ( P < 0.05 ) . Positive_regulation TNF CP 2460085 98223 Human recombinant tumour necrosis factor ( [cachectin] ) *induced* a dose dependent increase in synthesis of haptoglobin and . Positive_regulation TNF CPA1 8931762 397878 [TNF alpha] was *increased* by 1000 ng/ml at 12 h and by 500 , 1000 and 5000 ng/ml CPA at 1-3 days . Positive_regulation TNF CPA1 9754866 535252 [TNF-alpha] release *induced* by DTBHQ and was inhibited by treatment with actinomycin-D , the immunosuppressant FK506 and the glucocorticoid dexamethasone ( p < or = 0.01 ) . Positive_regulation TNF CPB1 12212211 767354 Both and operative stimulus *induce* the increase of cytokine [TNF-alpha] after CPB . Positive_regulation TNF CPB1 19106809 2093286 Although inflammatory capacity and TNF-alpha synthesis were altered on monocytes after cardiopulmonary bypass (CPB) , whether the CPB and the *induced* [TNF-alpha] affect TLR4 expression on monocytes have not yet clarified . Positive_regulation TNF CPB1 19106809 2093291 To elucidate whether the *induced* [TNF-alpha] is related to TLR4 down-regulation , we used human monocytic THP-1 cells . Positive_regulation TNF CPB1 19923057 2166983 *resulted* in increased [TNF-alpha] and IL-1beta production in the lung tissues . Positive_regulation TNF CPB1 9456097 484484 Aprotinin , a serine protease inhibitor used primarily to reduce blood loss after CPB , reduces *induced* proinflammatory cytokine [tumor necrosis factor-alpha] release similarly to glucocorticoids . Positive_regulation TNF CPB2 12212211 767355 Both and operative stimulus induce the *increase* of cytokine [TNF-alpha] after CPB . Positive_regulation TNF CPB2 19106809 2093287 Although inflammatory capacity and TNF-alpha synthesis were altered on monocytes after cardiopulmonary bypass (CPB) , whether the CPB and the *induced* [TNF-alpha] affect TLR4 expression on monocytes have not yet clarified . Positive_regulation TNF CPB2 19106809 2093292 To elucidate whether the *induced* [TNF-alpha] is related to TLR4 down-regulation , we used human monocytic THP-1 cells . Positive_regulation TNF CPB2 19923057 2166984 *resulted* in increased [TNF-alpha] and IL-1beta production in the lung tissues . Positive_regulation TNF CPB2 9456097 484485 Aprotinin , a serine protease inhibitor used primarily to reduce blood loss after CPB , reduces *induced* proinflammatory cytokine [tumor necrosis factor-alpha] release similarly to glucocorticoids . Positive_regulation TNF CPE 18424588 1899919 ( 100 mg/L , 0.5-4 h ) *increased* TTP and [tumor necrosis factor (TNF)] mRNA levels by up to 2- and 6-fold that of the control , respectively , and the base level of TTP was 6-fold that of TNF . Positive_regulation TNF CPOX 21269535 2443169 The results showed that L137 significantly *inhibited* both prostanoid and [TNF-a] production in lipopolysaccharide primed human monocytes in a dose dependent manner , by inhibiting the activity of COX-2 . Positive_regulation TNF CR2 9862364 555901 Soluble *induced* an increase in intracellular cGMP levels and the production of IL-6 and [TNF-alpha] in IL-4 pretreated monocytes induced to express CD23 but not in unstimulated CD23- monocytes . Positive_regulation TNF CREB1 10383461 624616 Furthermore , overexpression of CREB but not mutated CREB by retroviral mediated gene transfer reversed hypoxia elicited induction of TNF-alpha defining a causal relationship between hypoxia elicited reduction and [TNF-alpha] *induction* . Positive_regulation TNF CREB1 14999073 1216748 Using CREB antisense to determine the causal relationship between V1 agonist induced CREB activation and suppression of IL-1beta and TNF-alpha , we demonstrated that decreased IL-1beta and [TNF-alpha] gene expression was *dependent* on upstream activation . Positive_regulation TNF CREB1 15242860 1289509 [TNF-alpha] *induced* phosphorylation with a peak at 15 minutes of stimulation . Positive_regulation TNF CREB1 16715652 1565092 [TNFalpha] *induced* phosphorylation of with a peak at 15 min of stimulation in a dose dependent manner in bovine aortic ECs . Positive_regulation TNF CREB1 16879221 1593934 Further , we provide evidence for a [TNF-alpha] *induced* binding of NF-kappaB to the recently described kappaB site in the t-PA gene and of cyclic adenosine monophosphate response element binding protein ( ) to the t-PA CRE-like site . Positive_regulation TNF CREB1 1827793 158502 These results suggest that the [TNF-responsive] element is not *activated* by AP-1 or in U937 cells and that a novel DNA binding factor is important for constitutive and inducible TNF gene expression . Positive_regulation TNF CREB1 19339243 2074333 [TNF-alpha] *induced* phosphorylation in vitro and DNA binding and reporter gene activities in vivo . Positive_regulation TNF CREB1 19339243 2074339 [TNF-alpha] *induced* activation via ERK1/2 , and inhibition of ERK1/2 and CREB blunted TNF-alpha mediated WISP1 induction . Positive_regulation TNF CREB1 20303596 2230470 *Role* of in modulation of [TNFalpha] and IL-10 expression in LPS stimulated RAW264.7 macrophages . Positive_regulation TNF CREB1 20303596 2230499 Likewise , while over-expression of dominant negative *had* no effect on LPS stimulated [TNFalpha] production , it blocked the suppressive effect of isoproterenol on TNFalpha production in the LPS stimulated macrophages . Positive_regulation TNF CREB3 10383461 624617 Furthermore , overexpression of CREB but not mutated CREB by retroviral mediated gene transfer reversed hypoxia elicited induction of TNF-alpha defining a causal relationship between hypoxia elicited reduction and [TNF-alpha] *induction* . Positive_regulation TNF CREB3 14999073 1216749 Using CREB antisense to determine the causal relationship between V1 agonist induced CREB activation and suppression of IL-1beta and TNF-alpha , we demonstrated that decreased IL-1beta and [TNF-alpha] gene expression was *dependent* on upstream activation . Positive_regulation TNF CREB3 15242860 1289510 [TNF-alpha] *induced* phosphorylation with a peak at 15 minutes of stimulation . Positive_regulation TNF CREB3 16715652 1565093 [TNFalpha] *induced* phosphorylation of with a peak at 15 min of stimulation in a dose dependent manner in bovine aortic ECs . Positive_regulation TNF CREB3 16879221 1593935 Further , we provide evidence for a [TNF-alpha] *induced* binding of NF-kappaB to the recently described kappaB site in the t-PA gene and of cyclic adenosine monophosphate response element binding protein ( ) to the t-PA CRE-like site . Positive_regulation TNF CREB3 1827793 158503 These results suggest that the [TNF-responsive] element is not *activated* by AP-1 or in U937 cells and that a novel DNA binding factor is important for constitutive and inducible TNF gene expression . Positive_regulation TNF CREB3 19339243 2074334 [TNF-alpha] *induced* phosphorylation in vitro and DNA binding and reporter gene activities in vivo . Positive_regulation TNF CREB3 19339243 2074340 [TNF-alpha] *induced* activation via ERK1/2 , and inhibition of ERK1/2 and CREB blunted TNF-alpha mediated WISP1 induction . Positive_regulation TNF CREB3 20303596 2230471 *Role* of in modulation of [TNFalpha] and IL-10 expression in LPS stimulated RAW264.7 macrophages . Positive_regulation TNF CREB3 20303596 2230500 Likewise , while over-expression of dominant negative *had* no effect on LPS stimulated [TNFalpha] production , it blocked the suppressive effect of isoproterenol on TNFalpha production in the LPS stimulated macrophages . Positive_regulation TNF CREB5 10383461 624615 Furthermore , overexpression of CREB but not mutated CREB by retroviral mediated gene transfer reversed hypoxia elicited induction of TNF-alpha defining a causal relationship between hypoxia elicited reduction and [TNF-alpha] *induction* . Positive_regulation TNF CREB5 14999073 1216747 Using CREB antisense to determine the causal relationship between V1 agonist induced CREB activation and suppression of IL-1beta and TNF-alpha , we demonstrated that decreased IL-1beta and [TNF-alpha] gene expression was *dependent* on upstream activation . Positive_regulation TNF CREB5 15242860 1289508 [TNF-alpha] *induced* phosphorylation with a peak at 15 minutes of stimulation . Positive_regulation TNF CREB5 16715652 1565091 [TNFalpha] *induced* phosphorylation of with a peak at 15 min of stimulation in a dose dependent manner in bovine aortic ECs . Positive_regulation TNF CREB5 16879221 1593933 Further , we provide evidence for a [TNF-alpha] *induced* binding of NF-kappaB to the recently described kappaB site in the t-PA gene and of cyclic adenosine monophosphate response element binding protein ( ) to the t-PA CRE-like site . Positive_regulation TNF CREB5 1827793 158501 These results suggest that the [TNF-responsive] element is not *activated* by AP-1 or in U937 cells and that a novel DNA binding factor is important for constitutive and inducible TNF gene expression . Positive_regulation TNF CREB5 19339243 2074332 [TNF-alpha] *induced* phosphorylation in vitro and DNA binding and reporter gene activities in vivo . Positive_regulation TNF CREB5 19339243 2074338 [TNF-alpha] *induced* activation via ERK1/2 , and inhibition of ERK1/2 and CREB blunted TNF-alpha mediated WISP1 induction . Positive_regulation TNF CREB5 20303596 2230469 *Role* of in modulation of [TNFalpha] and IL-10 expression in LPS stimulated RAW264.7 macrophages . Positive_regulation TNF CREB5 20303596 2230498 Likewise , while over-expression of dominant negative *had* no effect on LPS stimulated [TNFalpha] production , it blocked the suppressive effect of isoproterenol on TNFalpha production in the LPS stimulated macrophages . Positive_regulation TNF CREBBP 10760264 683516 A stimulus-specific role for in T cell receptor *activated* [tumor necrosis factor] alpha gene expression . Positive_regulation TNF CRH 11852909 913319 Indomethacin or dipyrone reduced LPS , IL-1beta , IL-6 or [TNF-alpha] *induced* fever and release from rat hypothalamus . Positive_regulation TNF CRH 12379683 997307 We have found that *enhanced* lipopolysaccharide (LPS) induced [tumor necrosis factor alpha (TNF-alpha)] , interleukin-1beta (IL-1beta) , and IL-6 production . Positive_regulation TNF CRH 12485415 1032925 *induces* proliferation and [TNF-alpha] release in cultured rat microglia via MAP kinase signalling pathways . Positive_regulation TNF CRH 12485415 1032927 In the present study , we show that , acting on CRH-R1 , *promoted* cell proliferation and [tumour necrosis factor-alpha (TNF-alpha)] release in cultured rat microglia . Positive_regulation TNF CRH 12485415 1032950 These results suggest that *induces* cell proliferation and [TNF-alpha] release in cultured microglia via MAP kinase signalling pathways , thereby providing insight into the interactions between CRH and inflammatory mediators . Positive_regulation TNF CRH 15073568 1184295 at all concentrations significantly *blocked* the 5-HT ( 1.5 microg/mL and 15 microg/mL ) -induced suppression of [TNFalpha] production . Positive_regulation TNF CRH 8930939 397740 In addition , *increased* ACTH , beta-EPH and [TNF alpha] levels in the culture medium of three ACTH secreting tumors at the doses of 100 nmol/l and 1 mumol/l ( greater than 300 , 200 and 110 % of baseline pretreatment incubation levels , respectively ) . Positive_regulation TNF CRK 10521481 653089 The study presented here shows that autoregulation of [TNF-alpha] gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* mitogen activated protein (MAP) kinase activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation TNF CRK 10753189 681726 Here we show that treatment of primary rat hepatocyte cultures with nafenopin causes an increase in bioactive [TNF-alpha] and that this process *requires* MAP kinase activity . Positive_regulation TNF CRK 11087751 810078 Activation of mitogen activated protein kinase and extracellular signal regulated kinase is *involved* in glass fiber induced [tumor necrosis factor-alpha] production in macrophages . Positive_regulation TNF CRK 11353829 815141 Fluid shear stress inhibits [TNF-alpha] *activation* of JNK but not ERK1/2 or in human umbilical vein endothelial cells : Inhibitory crosstalk among MAPK family members . Positive_regulation TNF CRK 11675371 873197 Both extracellular receptor kinase (ERK) and can *regulate* [TNF-alpha] gene transcription induced by CpG DNA . Positive_regulation TNF CRK 12391245 1007377 Release of [TNF-alpha] , macrophage-inflammatory protein (MIP)-2 ( MIP-1beta ) , and IL-8 by LPS stimulated neutrophils was also *reduced* by poststimulation MAPK inhibition . Positive_regulation TNF CRK 12393915 1025395 This model probiotic also inhibits *activation* of the pro-apoptotic activated protein kinase by [tumor necrosis factor] , interleukin-1alpha , or gamma-interferon . Positive_regulation TNF CRK 14688078 1190336 [TNF-alpha] also *induced* the phosphorylation of . Positive_regulation TNF CRK 15611271 1357353 However , inhibitors of serine/threonine protein phosphatase type 1 and type 2A significantly increased IL-6 and [TNF-alpha] levels , and prolonged *activation* of and ERK1/2 when triggered by TLR4 and TLR9 ligands . Positive_regulation TNF CRK 16060858 1531759 [TNFalpha] *induced* rapid phosphorylation of the stress activated and JNK ( c-Jun N-terminal kinase ) MAPKs ( mitogen activated protein kinases ) ; Positive_regulation TNF CRK 16117790 1449202 Inhibitors for nuclear factor kappa B (NFkappaB) , parthenolide , and Bay 11-7085 , and an inhibitor of , SB202190 , *inhibited* [TNFalpha-] and IFNgamma induced production of CCL17 by HaCaT KC. Surprisingly , an inhibitor of epidermal growth factor receptor tyrosine kinase , PD153035 , enhanced the production of CCL17 in HaCaT KC. Roxithromycin ( RXM ) , a 14-membered ring macrolide , suppressed CCL17 production by HaCaT KC induced by IFNgamma and TNFalpha . Positive_regulation TNF CRK 16269458 1509284 On the other hand , [TNFalpha] and IL-1beta *induced* , c-Jun N-terminal kinase (JNK) , and nuclear factor (NF)kappaB activation , pathways more closely related to stress response . Positive_regulation TNF CRK 16723255 1570415 In cells progressing through S-phase , [TNFalpha] *activation* of IKK , JNK , and is significantly reduced . Positive_regulation TNF CRK 17763449 1801853 Furthermore , APC directly suppressed the production of [tumor necrosis factor (TNF)] and the *activation* of NF-kappaB and MAP kinase , and inhibitors of NF-kappaB or p38 reduced the production of MMP-9 , suggesting that APC inhibits MMP-9 by blocking TNF , NF-kappaB , and p38 . Positive_regulation TNF CRK 18562577 1924121 The H ( 2 ) O ( 2 ) induced [TNF-alpha] production was *prevented* by inhibitors of and stress activated protein kinase ( SAPK/JNK ) , and H ( 2 ) O ( 2 ) induced the phosphorylation of p38 and SAPK . Positive_regulation TNF CRK 19052649 1999779 This was followed by MAPK activation and *resulted* in a time dependent increase in [TNF-alpha] production . Positive_regulation TNF CRK 19541467 2142429 [TNF-alpha] *induced* and extracellular signal regulated kinase 1/2 ( ERK1/2 ) activities that contributed to VCAM-1expression was obviously attenuated after pre treating RAECs with paeonol . Positive_regulation TNF CRK 20646342 2292557 [TNF-alpha] *induced* a significant increase in MAPK phosphorylation . Positive_regulation TNF CRK 21924259 2492064 Furthermore , [TNF-a] *induced* MAP kinase activity in the smooth muscle cells was completely inhibited by nomilin . Positive_regulation TNF CRK 22137267 2636443 This compound effectively *inhibited* the expression of proinflammatory cytokines [TNF-a] and IL-6 in low micromole levels by inhibiting NF-?B activation and and JNK phosphorylation . Positive_regulation TNF CRK 9177222 434128 Expression of activated MEKK1 ( DeltaMEKK1 ) in MC/9 cells strongly stimulated JNK activity but only weakly stimulated activity , and it *induced* a large activation of [TNF-alpha] promoter regulated luciferase gene expression . Positive_regulation TNF CRK 9418855 480522 These findings provide evidence for a *role* of NaSal induced MAPK activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Positive_regulation TNF CROT 15575964 1347771 Animal and tissue culture studies have shown that is *involved* in interleukin-2 (IL-2) and [tumor necrosis factor-alpha (TNF-alpha)] production by T-cells contributing to T-cell proliferation . Positive_regulation TNF CROT 20089988 2201570 Furthermore , we found that was *involved* in the induction of [TNF-alpha] mRNA expression in gingiva of mice with experimental periodontitis . Positive_regulation TNF CRP 20434119 2256595 We have previously reported that lupus monocytes display distinctively differing patterns of *inducing* cytokine interleukin (IL)-6 , IL-1beta , and [tumor necrosis factor (TNF)-alpha] secretion when stimulated with either immune complexes ( ICs ) or lipopolysaccharide (LPS) . Positive_regulation TNF CRP 20676742 2447317 *induces* [TNF-a] secretion by p38 MAPK-TLR4 signal pathway in rat vascular smooth muscle cells . Positive_regulation TNF CRP 2454996 93465 These results indicate that human SAA and are *induced* in Hep 3B cells by products of activated monocytes but not by IL-1 beta , [TNF-alpha] , or some hepatocyte stimulating factor preparations and that a group of heterogeneous mechanisms are involved in the induction of the various human APP . Positive_regulation TNF CRP 9777287 540242 The other proinflammatory cytokines IL-1 beta , and [TNF alpha] remained unchanged , and the increased serum IL-6 did not *induce* production of . Positive_regulation TNF CRYGEP 17445776 1737159 activated NF-kappaB in a TLR4 dependent manner and *stimulated* [TNF-alpha] production in bone marrow cells of TLR4-functional C3H/HeN mice but not in those of TLR4-defective C3H/HeJ mice . Positive_regulation TNF CRYGEP 22185916 2537216 Furthermore , ( 4 ) *increased* the levels of [tumor necrosis factor (TNF)-a] , interleukin (IL)-6 , IL-10 and cyclooxygenase (COX)-2 . Positive_regulation TNF CSDE1 11116146 786589 NF-kappaB activation by the [tumor necrosis factor receptor (TNFR)] *involves* the formation of a termed a signalosome . Positive_regulation TNF CSE 10435757 634444 Both RSV infection and *stimulated* [TNF-alpha] release from monocytes and there was an additive effect if both the agents were present . Positive_regulation TNF CSE 16543607 1582132 also *enhanced* expression and production of MUC5AC mucin induced by epidermal growth factor receptor (EGFR) ligands TGF-alpha and amphiregulin , as well as LPS- and [TNF-alpha-] induced expression and/or release of TGF-alpha and amphiregulin . Positive_regulation TNF CSE 19190237 2061270 IL-1beta increased the ChAT and M ( 3 ) , [TNF-alpha] down-regulated M ( 2 ) , and *increased* ChAT and M ( 3 ) expression while down regulating the expression of M ( 2 ) in HFL-1 cells . Positive_regulation TNF CSE 20653771 2293317 The aim of this study was to investigate the signalling of CSE induced Egr-1 expression and the role for Egr-1 in *induced* [TNF-alpha] expression . Positive_regulation TNF CSE 20653771 2293321 Involvement of Egr-1 in *induced* [TNF-alpha] secretion was determined by using Egr-1 specific siRNA . Positive_regulation TNF CSE 22359478 2520903 However , *had* no effect on [TNF-a] secretion and NF-?B activation . Positive_regulation TNF CSE 24282280 2898682 RNA interference mediated attenuation of MUC1 suppressed *induced* secretion of [TNF-a] from macrophages , by suppressing the activity of the TNF-a converting enzyme ( TACE ) , arguing that MUC1 is required for CSE induced and TACE mediated TNF-a secretion . Positive_regulation TNF CSF1 12507582 1038414 Our results indicate that , in the *presence* of , TNFalpha is sufficient for inducing human osteoclast differentiation from arthroplasty macrophages and that [TNFalpha] acts synergistically with IL-1alpha to stimulate lacunar resorption . Positive_regulation TNF CSF1 14607912 1162110 BM osteoclasts were induced by [TNF-alpha] as well as receptor activator of NF-kappaB ligand in the *presence* of . Positive_regulation TNF CSF1 1507728 196426 The production of TNF by in vitro culture of PBMC with OK432 of 0.05 KE/ml was augmented by adding 100 U/ml M-CSF especially at 48 and 72 hours of incubation , whereas alone did not *stimulated* [TNF] production . Positive_regulation TNF CSF1 1532988 183376 Different molecular mechanisms lead to same endpoints with different function : [TNF-alpha] *induces* non-functional receptors on HL-60 cells in contrast to interferon-gamma . Positive_regulation TNF CSF1 15479886 1319911 IL18 , IL1 beta , and [TNF alpha] did not *induce* , GM-CSF , IFN gamma , or OPG production in PHA prestimulated T cells or RA synovial T cells . Positive_regulation TNF CSF1 1698425 141448 Previous work suggested that [TNF] *induces* gene expression through activation of phospholipase A2 and eicosanoid production . Positive_regulation TNF CSF1 1739124 182035 Bacterial lipopolysaccharide (LPS) , recombinant human interleukin-1 alpha (IL-1 alpha) or [tumor necrosis factor alpha (TNF alpha)] *induced* mRNA accumulation in a concentration dependent manner in both EC and SMC . Positive_regulation TNF CSF1 17533390 1746639 We also found that osteoclast differentiation occurred when Ewing 's TAMs were cultured with [tumour necrosis factor (TNF)-alpha] in the *presence* of and that TC71 Ewing 's sarcoma cells stimulated osteoclast formation through the release of a soluble factor , the action of which was abolished by an antibody to TNF-alpha . Positive_regulation TNF CSF1 18085662 1847282 We found that Ki20227 inhibited M-CSF dependent reactions , such as lipopolysaccharide induced [tumor necrosis factor-alpha] production , which were *enhanced* by in vitro . Positive_regulation TNF CSF1 18313744 1879828 Experiments employing neutralising antibodies indicate that exposure of co-cultured macrophages to both Ti-based particles *induces* the release of , GM-CSF , IL-6 and PGE2 through up-regulation of IL-1beta and [TNF-alpha] . Positive_regulation TNF CSF1 1912581 167577 Previous studies have demonstrated that [tumor necrosis factor (TNF)] *induces* transcription of the gene in human myeloid cells . Positive_regulation TNF CSF1 1990292 152372 [Cachectin/tumor] necrosis factor transiently *induced* the expression of and inhibited the differentiation of H-1/A cells into adipocytes . Positive_regulation TNF CSF1 2428865 62854 Macrophage growth factor *stimulates* human monocyte production of interferon , [tumor necrosis factor] , and colony stimulating activity . Positive_regulation TNF CSF1 7912999 262027 It was found that IL-12 induces mRNA accumulation and production of GM-CSF and [TNF-alpha] from both T and NK cells and , as tested on NK cells only , *induces* mRNA accumulation . Positive_regulation TNF CSF1 8647916 366337 These results suggest that [TNF-alpha] *induces* expression in osteoblasts by a transcriptional mechanism which is largely independent of new protein synthesis and of the second messenger pathways examined . Positive_regulation TNF CSF1 8742369 378960 These may caused by differences in the *induced* production of [TNF-alpha] and IL-6 . Positive_regulation TNF CSF2 10385526 625563 We show that A20 does not inhibit TNF- induced nuclear translocation and DNA binding of NF-kappaB , although it completely prevents the [TNF-] induced *activation* of an NF-kappaB dependent reporter gene , as well as TNF induced IL-6 and granulocyte gene expression . Positive_regulation TNF CSF2 10562301 567018 IL-18 independently promoted and nitric oxide production , and it *induced* significant [TNF-alpha] synthesis by CD14 ( + ) macrophages in synovial cultures ; Positive_regulation TNF CSF2 10713329 675934 Neither or IL-3 *increased* the expression or secretion of [TNF receptor p55 (TNF-Rp55)] , although both agents increased expression of TNF receptor p75 (TNF-Rp75) . Positive_regulation TNF CSF2 10718863 676768 These findings suggest that the protective effect of may be *mediated* by the attenuated release of [TNFalpha] and indicate that the level of neutrophils in either blood or injured tissue does not influence significantly the viability of rat muscle after IR injury . Positive_regulation TNF CSF2 10764146 683988 Both GM-CSF and [TNF] induced caspase 3-like activity in this cell line though the time course was distinct between two cytokines , and combined stimulation of cells with plus TNF *induced* additive or synergistic activation of caspase 3-like activity . Positive_regulation TNF CSF2 10764326 683998 Mean [TNF-alpha] release by AM in *response* to was higher in control subjects than in PAP patients due to a low response in three patients . Positive_regulation TNF CSF2 10822085 694695 [TNF-alpha] *induced* expression of both IL-8 and , without detectable production of RANTES . Positive_regulation TNF CSF2 10825585 696829 Proliferation ( 5/14 ) or increased survival ( 7/14 ) of AML cells was observed in the *presence* of , SCF , and [TNF-alpha] . Positive_regulation TNF CSF2 10903772 713207 [TNF-alpha] , IL-1beta , and PMA *induced* the release of in HBECs . Positive_regulation TNF CSF2 11108836 757032 [Tumor necrosis factor (TNF)] induces osteoclast differentiation from bone marrow cells in the *presence* of macrophage . Positive_regulation TNF CSF2 11119498 768400 may also *regulate* IFN-gamma and [TNF-alpha] production and activity in response to infection . Positive_regulation TNF CSF2 11179120 784466 COX-2 inhibition or blocking of the TX receptor abolished the *induced* bronchoconstriction , but not the [TNF] release . Positive_regulation TNF CSF2 11266094 796698 added to cell cultures 24 h before induction significantly *enhanced* the production of IL-1alpha , IL-1beta and [TNF-alpha] in controls , but only IL-1alpha and IL-1beta in the blood cell cultures of patients with ALL . Positive_regulation TNF CSF2 11501160 766117 The *promoted* [TNF-alpha] , IL-6 , and IL-8 inductions of monocytes and increased the percentages of CD11b , CD16 , HLA I , and HLA II molecule expression on monocytes . Positive_regulation TNF CSF2 11600571 870741 Mature DCs were generated from peripheral blood monocytes in the *presence* of granulocyte macrophage , IL-4 , and [TNFalpha] . Positive_regulation TNF CSF2 12452842 1020586 Indeed , parallel studies with PMN of healthy donors showed that while IFN-gamma and granulocyte/macrophage ( GM-CSF ) induced both , MHC class II and CD83 , [tumour necrosis factor (TNF)-alpha] selectively *induced* de novo synthesis of CD83 . Positive_regulation TNF CSF2 1353987 192650 IL-4 , IL-6 , and IFN-gamma *had* no effect on [TNF-alpha] production by T cells activated via either pathway . Positive_regulation TNF CSF2 1375667 188209 Recently , it has been reported that blood neutrophils may synthesize mRNA and proteins important in inflammation including various cytokines such as IL-1 , IL-6 , TNF-alpha and IFN-alpha , but , administration of rhG-CSF showed no obvious effect on the level of either IL-1 , IL-6 , TNF-alpha or IFN-alpha in sera , and furthermore , the in vitro stimulation by *induced* no significant production of these cytokines and expressions of [TNF-alpha] and IFN-alpha mRNAs . Positive_regulation TNF CSF2 14530752 1149398 In the sepsis/multiple organ failure group , also *enhanced* HLA-DR expression and [TNF alpha] production , although the levels of the volunteers ' blood were not reached . Positive_regulation TNF CSF2 15143479 1247488 *stimulates* the release of [TNF-alpha] and the expression of iNOS . Positive_regulation TNF CSF2 15211029 1262150 We observed constitutive expression of interleukin (IL)-6 , IL-8 , granulocyte macrophage colony stimulating factor ( ) , and monocyte chemoattractant protein (MCP)-1 in both human and baboon endothelial cells , and these cytokines were further *induced* by [TNF-alpha] and LPS . Positive_regulation TNF CSF2 15743002 1352200 *induced* [TNF] release , and co-culture with LPS 1.0 or 10.0 ng/mL was strongly synergistic . Positive_regulation TNF CSF2 15743002 1352202 CARD15 1007fs mutation was linked in a gene-dose dependent manner to low [TNF] release *induced* by ( P value for linear trend = 0.001 ) . Positive_regulation TNF CSF2 15968243 1423746 Compared with basal levels , *increased* [TNF-alpha] production of monocytes both in blood samples from patients ( median , 1320 pg/mL ; range , 35-8015 pg/mL ) and controls ( median , 3450 pg/mL ; range , 1040-9835 pg/mL ; both P < 0.001 ) . Positive_regulation TNF CSF2 1617321 191269 Levels of [TNF-alpha] transcripts *induced* by were maintained for at least 36 h , in contrast to lipopolysaccharide (LPS) stimulation which caused TNF-alpha mRNA levels to peak after 2 h and decline rapidly thereafter . Positive_regulation TNF CSF2 16404477 1533539 Expression of the reporter gene was also demonstrated in the DC generated from transfected , purified CD34 ( + ) cord blood cells , by *stimulation* with , SCF , FL , and [tumor necrosis factor alpha (TNF-alpha)] . Positive_regulation TNF CSF2 16428068 1515850 [TNF-alpha-and] *induced* PGE2 release was blocked by the addition of the selective COX-2 inhibitor , N- ( 2-cyclohexyloxy-4-nitrophenyl ) -methanesulfonamide ( NS-398 ; 1 microM ) . Positive_regulation TNF CSF2 1651781 164366 [TNF] alone *induced* only production in these cells , but in the presence of LiCl , increased amounts of GM-CSF as well as small amounts of IL-2 and IL-6 could be detected . Positive_regulation TNF CSF2 16522458 1531294 Moreover , IL-17E and [TNF-alpha] synergistically *induced* and CXCL-8 mRNA . Positive_regulation TNF CSF2 16704300 1560676 was *required* for the induction of [TNF-alpha] by SCG , and in turn , TNF-alpha enhanced the release of GM-CSF and thereby augmented the induction of IL-12p70 and IFN-gamma by SCG . Positive_regulation TNF CSF2 16716600 1570289 Conversely , *had* no effect on the pre-PHx mRNA levels or the PHx induced upregulation of mRNA levels of [TNF-alpha] , IL-1beta , IL-6 , TGF-beta , IL-10 , HGF , and c-Met determined by real-time RT-PCR . Positive_regulation TNF CSF2 17250654 1718025 The *dependent* expression and secretion of inflammatory cytokine/chemokine , [TNF-alpha] , IL-1beta , IL-6 , and IP-10 , is cytotoxic to oligodendrocytes , the myelin forming cells in the central nervous system , and as well as neurons . Positive_regulation TNF CSF2 1906383 161720 synergistically *enhanced* [TNF-alpha] secretion induced by IFN-gamma but not by lipopolysaccharide . Positive_regulation TNF CSF2 1906383 161722 did not *enhance* [TNF-alpha] secretion induced by IL-2 or TNF-alpha . Positive_regulation TNF CSF2 19103778 2036448 The induction of [TNF-alpha] and IL-1beta was largely *due* to granulocyte-macrophage produced by infected osteoblasts , as demonstrated by inhibition with a specific neutralizing antibody . Positive_regulation TNF CSF2 19590023 2130055 Collectively , these findings indicate that [TNF-alpha] released from activated resident alveolar macrophages *induces* epithelial expression , which in turn initiates AEC proliferation and contributes to restoring alveolar barrier function . Positive_regulation TNF CSF2 1966932 152083 IFN gamma alone did not induce either cytokine , but in the *presence* of it caused a synergistic ( 100-fold ) increase in [TNF] but not IL-1 production . Positive_regulation TNF CSF2 2012180 156675 In addition , IL-1 beta and [TNF-alpha] *induced* high levels of granulocyte-macrophage colony stimulating factor ( GM-CSF ) and macrophage ( M-CSF ) mRNAs . Positive_regulation TNF CSF2 2026869 157466 Both IL-1 beta and [TNF-alpha] *induced* mRNA accumulation , with a maximum effect after 4 h of stimulation . Positive_regulation TNF CSF2 20705940 2437280 We show that GM-CSF and [TNF-a] *increase* and/or maintain mRNA levels for the pro-apoptotic BH3-only protein Bid and that has a similar NF-?B dependent effect on Bim transcription and BimEL expression . Positive_regulation TNF CSF2 2118971 139880 produced a dose dependent *increase* in [TNF] release by KC in vitro with a parallel increase in MCA26 killing . Positive_regulation TNF CSF2 21597760 345770 [Tnf-alpha] *induces* secretion in leukemic-cell lines u-937 and kg-1a . Positive_regulation TNF CSF2 21597760 345772 Recently it has been shown that IL-1 and [TNF-alpha] can *induce* production in fresh leukemic cells of patients who do not release GM-CSF spontaneously . Positive_regulation TNF CSF2 21607339 290629 Serum [tumor necrosis factor] levels were not *increased* by . Positive_regulation TNF CSF2 2183930 131949 We found that recombinant human *stimulated* [TNF] production by the same cells as the tumor conditioned medium . Positive_regulation TNF CSF2 2404745 128007 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant interleukin 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF CSF2 2404745 128026 These results suggest that human osteoblasts , which have been shown previously to respond to TNF alpha , can synthesize and release [TNF] in *response* to IL1 and granulocyte-macrophage . Positive_regulation TNF CSF2 2460533 98576 Using Northern blot analysis to detect tissue levels of hematopoietic growth factor-specific transcripts , and specific biologic and immunologic assays to detect the presence of colony stimulating factors in the serum , we have found that [TNF-alpha] and TNF-beta *induce* the transcription and production of , macrophage-CSF , and IL-1 . Positive_regulation TNF CSF2 2473121 113845 Although potently *induced* [TNF-alpha] gene transcription by 20 h of treatment , PGE2 interfered with translation into the secreted TNF-alpha protein . Positive_regulation TNF CSF2 2788173 116795 [TNF-alpha] *induces* production by endothelial cells and may therefore provide a paracrine loop to support leukemia growth . Positive_regulation TNF CSF2 3128401 91760 in vitro also did not *stimulate* the tumoricidal function of normal monocytes or the secretion of interleukin-1 or [tumor necrosis factor] . Positive_regulation TNF CSF2 3137258 95928 alone did not *stimulate* IL-1 or [TNF-alpha] activities or the production of PGE2 . Positive_regulation TNF CSF2 3139106 97365 In addition , interferon-gamma (INF-gamma) upregulated the amount of [TNF] *induced* by in all donors examined , with variable effect on IL-1 alpha and IL-1 beta . Positive_regulation TNF CSF2 3294900 73583 Human granulocyte-macrophage *induces* expression of the [tumor necrosis factor] gene by the U937 cell line and by normal human monocytes . Positive_regulation TNF CSF2 3489188 62584 Recombinant human [TNF] *induces* production of granulocyte-monocyte . Positive_regulation TNF CSF2 7505398 237619 Enzyme linked immunosorbent assay showed four of 10 glioblastoma cell lines spontaneously released GM-CSF ( 2.9-9.2 pg GM-CSF protein/ml culture medium ) , which was enhanced by stimulation with tumor necrosis factor-alpha (TNF) ( 10 U/ml ) up to 410 pg/ml . [TNF] also *induced* secretion of by another cell line . Positive_regulation TNF CSF2 7521152 269290 In the presence of ATRA , *potentiated* production and secretion of [tumor necrosis factor-alpha (TNF)] in response to lipopolysaccharide , as well as interferon-gamma which is a potent inducer of monocytic differentiation in APL cells . Positive_regulation TNF CSF2 7530789 291757 IL-3 and granulocyte/macrophage *increased* secretion of IL-1 alpha , IL-1 beta and [TNF-alpha] for a majority of AML patients , whereas IL-4 decreased cytokine secretion . Positive_regulation TNF CSF2 7570333 324924 *Increase* in plasma [TNF-alpha] with no increase in during TPN , when food intake decreased , suggests an association between TPN and TNF-alpha but not necessarily cause and effect . Positive_regulation TNF CSF2 7681704 214339 This enhanced activity can be attributed , in part , to both inherent enhancing factor ( s ) on lymphocytes and PMN associated [TNF] *induced* by . Positive_regulation TNF CSF2 7691110 228735 Both IL-1 and [TNF alpha] *induced* a dose dependent release of IL-6 ( 5 to 10 ng/10 ( 6 ) cells ) and ( 2 to 3 ng/10 ( 6 ) cells ) by primary epithelial cells from eight normal volunteers . Positive_regulation TNF CSF2 8106292 245929 *Induction* of [tumor necrosis factor] in mice by recombinant human macrophage . Positive_regulation TNF CSF2 8123762 242022 Similar to LPS , IL-2 , IL-3 , and *induced* the expression of IL-1 beta , IL-6 , IL-8 , [TNF-alpha] , and IL-1-RA genes in monocytes , but with some differences in the amount and kinetics of cytokine mRNA accumulation . Positive_regulation TNF CSF2 8219193 231804 Mechanisms of [tumor necrosis factor-granulocyte-macrophage] *induced* dendritic cell development . Positive_regulation TNF CSF2 8228234 235719 In virus infected monocytes , induced a more rapid IFN-alpha release and *potentiated* production of [TNF-alpha] , IL-1 beta , and IL-6 . Positive_regulation TNF CSF2 8282065 247358 Regulation of interleukin-1 and [tumor necrosis factor-alpha] *induced* granulocyte-macrophage gene expression : potential involvement of arachidonic acid metabolism . Positive_regulation TNF CSF2 8319779 223126 and IFN-gamma combined with 1,25 ( OH ) 2D3 *increased* cellular [TNF] secretion to levels not seen with these agents alone . Positive_regulation TNF CSF2 8396850 230336 There was no significant change in the basal release of [tumor necrosis factor alpha (TNF-alpha)] or interleukin 1 beta (IL-1 beta) *induced* by . Positive_regulation TNF CSF2 8412318 233679 We provide experimental evidence that [TNF alpha] *induces* both GM-CSF gene expression and up-regulation of high-affinity membrane receptor in TNF alpha-responsive cells . Positive_regulation TNF CSF2 8635522 362069 To control for effects of trace levels of LPS in culture media , we examined CSF-1 and *stimulated* [TNF-alpha] production in relatively homogeneous populations of normal LPS-hyporesponsive C3H/HeJ BMM and a growth factor dependent cell line ( S1 ) of C3H/HeJ origin . Positive_regulation TNF CSF2 8647916 366330 [Tumor necrosis factor-alpha] *induces* transcription of the gene in murine osteoblasts . Positive_regulation TNF CSF2 8811844 383372 The results show that granulocyte-macrophage , macrophage colony stimulating factor and lipopolysaccharide differently *regulate* [TNF alpha] protein expression and suggest that different isoforms may have different functions . Positive_regulation TNF CSF2 9006322 410721 We found that overexpression did not *enhance* production of [tumor necrosis factor-alpha] in a significant manner at any time after GM-CSF gene transfer . Positive_regulation TNF CSF2 9058823 417713 Granulocyte-macrophage and IFN-gamma *restore* the systemic [TNF-alpha] response to endotoxin in lipopolysaccharide desensitized mice . Positive_regulation TNF CSF2 9058823 417719 In cultures of murine monocyte/macrophage containing cell populations , i.e. , alveolar , peritoneal , spleen , bone marrow cells , or blood , the presence of or IFN-gamma ( 10 ng/ml ) *resulted* in an enhanced release of [TNF-alpha] initiated by 1 microg/ml LPS . Positive_regulation TNF CSF2 9197377 438536 However , granulocyte-macrophage ( GM-CSF ) , a cytokine that enhances HIV replication in M/Ms and is frequently used to propagate monocytotropic strains of HIV , can *induce* the relatively long-term production of IL-6 ( up to 47 U/ml ) and [TNF-alpha] ( up to 47 pg/ml ) by M/Ms , even in the absence of HIV . Positive_regulation TNF CSF2 9459614 475711 The results suggest that in inflammatory processes , and IFN-gamma *contribute* to increased synthesis of [TNF-R75] by monocytic cells , a prerequisite for the formation of large amounts of soluble receptors . Positive_regulation TNF CSF2 9564808 500745 In contrast , spontaneous release of IL-1alpha , IL-1ra , GM-CSF , and [TNF-alpha] was *increased* in the supernatants of unstimulated keratinocytes from patients with AD compared with keratinocytes from control subjects , with IL-1ra and reaching statistically significant difference . Positive_regulation TNF CSF2 9605989 508251 plus F. nucleatum or P. gingivalis LPS activated THP-1 cells to produce a 1.6-fold *increase* in [TNF-alpha] production at 4 h over LPS stimulation alone . Positive_regulation TNF CSF2 9766635 538434 [TNF-alpha] stimulated a dose dependent increase in ERK and p38 MAPK activities that was maximal at 10 min. JNKs were not *stimulated* by TNF-alpha or . Positive_regulation TNF CSF3 10792294 689248 In addition to increasing the numbers of neutrophils in vivo and modulating neutrophil functions , may *induce* the production of cytokines such as [tumour necrosis factor alpha (TNF-alpha)] . Positive_regulation TNF CSF3 10792294 689250 In vitro , did not *enhance* the secretion of [TNF-alpha] and GM-CSF from mononuclear cells , whole blood or endothelial cells . Positive_regulation TNF CSF3 10792294 689252 However , in the co-presence of whole blood and endothelial cells , the secretion of [TNF-alpha] was significantly *enhanced* by at low concentrations . Positive_regulation TNF CSF3 10792294 689253 These results together with our previous findings suggest that *induces* the production of [TNF-alpha] and GM-CSF in vivo , and that this production may be due to the co-effects of endothelial cells and whole blood under the influence of G-CSF through an as yet unknown network of cells and cytokines . Positive_regulation TNF CSF3 11011119 752632 [TNF-alpha] or IL-1beta *induced* both and PTHrP production in the conditioned medium . Positive_regulation TNF CSF3 7683736 216560 IL-3 , IL-6 , interferon gamma , and to a smaller extent IL-1 beta and GMCSF synergized the differentiation *inducing* activity of [TNF] . Positive_regulation TNF CSH2 1453299 205531 Human choriogonadotropin ( hCG ) and ( hPL ) inhibit interleukin-2 (IL-2) and *increase* interleukin-1 beta (IL-1 beta) , -6 ( IL-6 ) and tumor necrosis factor ( [TNF-alpha] ) expression in monocyte cell cultures . Positive_regulation TNF CSK 11310845 804847 Stimulation with also *resulted* in comparable production of [TNF-alpha] in LPS-responder and nonresponder BMDMs from C57Bl/10ScSn mice and C57Bl/10ScCr mice , respectively . Positive_regulation TNF CSK 16783405 1599401 In contrast , S. aureus ( TLR2/TLR1/TLR6 ) or Pam ( 3 ) ( TLR2/TLR1 ) , or FSL-1 and LTA ( TLR2/TLR6 ) *induced* [TNFalpha] without an effect on NO. 3 . Positive_regulation TNF CSK 17690330 1842478 Moreover , inhibition of PKR phosphorylation severely impaired [TNF-alpha] and IL-6 production by AM in *response* to LPS and . Positive_regulation TNF CSK 18372043 1892651 However , synergistically *enhanced* upLPS induced DC production of IL-10 but neither IL-12 p40 nor [TNF-alpha] . Positive_regulation TNF CSK 19019456 2016906 Expression of genes associated with the MyD88- ( TNF-alpha , IL-1ss , IL-6 and IL-10 ) and TRIF dependent pathways ( IFN-ss , IP-10 , RANTES and TRAF1 ) were measured at intervals spanning 20 h . LPS and Pam ( 3 ) ( 4 ) *induced* significantly higher expression of [TNF-alpha] , IL-1ss , and IL-10 than did Poly I:C . Positive_regulation TNF CSK 22525195 2595810 Ciclosporin alone did not alter the expression levels of these transcripts but in the presence of ciclosporin , TNF-a mRNA expression was upregulated in response to all three agonists and both [TNF-a] and IL-8 transcript abundance was increased in *response* to . Positive_regulation TNF CSK 22581266 2669456 We found that in vitro LPS and *induced* [TNF-a] , and IL-6 production are decreased in macrophages from GS/GS mice compared with WT mice ( p < 0.05 ) . Positive_regulation TNF CSK 24205328 2864790 Moreover , western blot results showed that TLRs activated PLK1 , and PLK1 inhibition by RNA interference down-regulated *induced* [TNF-a] production , suggesting the involvement of PLK1 in TNF-a up-regulation . Positive_regulation TNF CSK 24205328 2864794 Furthermore , GW843682X inhibited Pam3CSK4 induced activation of ERK and NF-?B , which contributed to *induced* up-regulation of [TNF-a] . Positive_regulation TNF CSN2 8872182 389641 While *had* no significant effects on IFN gamma production by ovine blood lymphocytes , and [TNF alpha] production and MCH Class II antigen expression by ovine bronchoalveolar macrophages , it enhanced IL-1 beta production by the macrophages , beta-casein also had no influence on bovine NK cell activity against a virally infected cell line . Positive_regulation TNF CSRP1 1424289 202245 ( iv ) [TNF-alpha] in the presence or absence of IL-6 and/or prednisolone did not *induce* the production of SAA or by HepG2 cells . Positive_regulation TNF CSRP1 14988254 1215016 Elevated levels are a strong independent predictor of type 2 diabetes and may *mediate* associations of [TNF-alphaR2] and IL-6 with type 2 diabetes . Positive_regulation TNF CSRP1 15653107 1364391 *induced* the enhanced release of IL-6 and [tnf-alpha] by 17-fold and 23-fold increase , respectively , in patients with unstable angina , while it did about 11-fold and 19-fold increase in patients with stable angina and normal group ( IL-6 : 3129+/-333 vs. 991+/-134 and 987+/-102 pg/ml , p < 0.01 , respectively ; Positive_regulation TNF CSRP1 15698590 1372325 *increased* the release of [TNF-alpha] rapidly as a dose-and time dependent manner . Positive_regulation TNF CSRP1 16123325 1461102 *increased* interleukin (IL)-1beta and [tumor necrosis factor (TNF)-alpha] . Positive_regulation TNF CSRP1 16751406 1571066 dramatically *increased* the production of [TNF-alpha] and IL-1beta in response to S. pneumoniae . Positive_regulation TNF CSRP1 16917108 1632847 Also , alone *increased* secretion of IL-8 , IL-6 , and [tumor necrosis factor] from HMDMs and did not inhibit LPS induced secretion of these cytokines . Positive_regulation TNF CSRP1 17531242 1848337 In human mononuclear cells , *induced* production of [tumor necrosis factor-alpha (TNF-alpha)] , interleukin-1 beta (IL-1 beta) , and matrix metalloproteinase-9 (MMP-9) in a concentration dependent manner . Positive_regulation TNF CSRP1 20676742 2447321 TLR4 knockdown significantly inhibited *induced* [TNF-a] generation , and p38 mitogen activated protein kinase (MAPK) blocker SB203580 depressed TLR4 expression and TNF-a production initiated by CRP in VSMCs . Positive_regulation TNF CSRP1 20676742 2447322 The data demonstrate that triggers an inflammatory response in rat VSMCs by *inducing* [TNF-a] secretion , which is mediated by p38 MAPK-TLR4 signaling pathway . Positive_regulation TNF CSRP1 22771801 2639591 These results collectively suggest that *regulates* adiponectin , [TNF-a] , leptin , IL-6 and PPAR-? genes expression , and that might represent a mechanism by which CRP regulates insulin resistance , obesity and metabolic syndrome . Positive_regulation TNF CSRP1 8482924 218895 Accordingly , we examined the capacity of alveolar macrophages -- relatively accessible human macrophages -- to produce interleukin-1 (IL-1) and [tumor necrosis factor alpha (TNF-alpha)] in *response* to . Positive_regulation TNF CST3 19446036 2136054 Exogenously added enhanced IFN-gamma induced activation of NF-kappaB p65 and *increased* mRNA levels for inducible NO synthase (iNOS) in cysC ( -/- ) macrophages as well as levels of nitric oxide and [TNF-alpha] in the cell culture medium , in agreement with an enhanced pro-inflammatory response . Positive_regulation TNF CTBS 23666609 2827832 Using the inhibitors of cathepsin enzymatic activity , it was found that and CtL *regulate* [TNF-a] production , the expression and secretion of NPC2 protein , and the mRNA levels of the genes involved in cholesterol trafficking in macrophages . Positive_regulation TNF CTCF 22354988 2572157 Depletion of *reduced* [TNF] expression and accelerated LTß induction . Positive_regulation TNF CTF1 20224758 2181107 *induces* [tumor necrosis factor] alpha synthesis in human peripheral blood mononuclear cells . Positive_regulation TNF CTF1 20224758 2181109 Therefore , we tested whether *induces* [TNFalpha] in PBMC of healthy volunteers . Positive_regulation TNF CTF1 20224758 2181110 Inhibitor studies with actinomycin D and brefeldin A showed that both protein synthesis and intracellular transport are essential for *induced* [TNFalpha] expression . Positive_regulation TNF CTGF 19922639 2176243 In addition , [tumour necrosis factor (TNF)alpha] can *induce* the production from synovial fibroblasts even though TNFalpha can oppositely inhibit the production of CTGF from chondrocytes . Positive_regulation TNF CTLA4 23634660 2790765 The engagement of on primary melanoma cell lines *induces* antibody dependent cellular cytotoxicity and [TNF-a] production . Positive_regulation TNF CTLA4 24295474 2880034 After 3 hours , CTLA4-Ig [ 100 µg/ml ] induced a significant decrease of [TNF-a] and IL-6 ( p < 0.05 ) , vs. cnt and [ 500 µg/ml ] further *reduced* TNF-a ( p < 0.001 ) , vs. cnt . Positive_regulation TNF CTNNB1 19558791 2099585 However , a loss of in porcine preadipocytes enhanced the adipogenic differentiation and *attenuated* [TNF-alpha] induced anti-adipogenesis . Positive_regulation TNF CTNND1 8639641 362554 *Role* of , a human homologue to the yeast chromosome segregation gene CSE1 , in toxin and [tumor necrosis factor] mediated apoptosis . Positive_regulation TNF CTR9 10422778 632387 However , exogenously added up to 100 nM did not *stimulate* production of [tumor necrosis factor-alpha] . Positive_regulation TNF CTR9 10435033 634210 [TNF-alpha] in the *presence* of WEB 2170 or CV 3988 , or was studied with the Greiss reagent method . Positive_regulation TNF CTR9 10921504 717353 antioxidants significantly inhibited both the in vivo and in vitro *induced* NF-kappaB activation and NF-kappaB dependent [TNF-alpha] expression . Positive_regulation TNF CTR9 15316260 1286191 The aim of this study was to determine [tumor necrosis factor alpha (TNF-alpha)] and interleukin-6 (IL-6) release in *response* to induction in peripheral blood mononuclear cells ( PBMCs ) from chronic hepatitis B virus ( HBV ) carriers . Positive_regulation TNF CTR9 15316260 1286211 Compared with group A , PBMCs from naturally immune subjects and chronic HBV carriers produced significantly higher amounts of [TNF-alpha] and IL-6 in *response* to . Positive_regulation TNF CTR9 15702351 1382759 Finally , up to 2 mug/ml , did not *induce* the production of pro-inflammatory cytokines such as IL-6 , IL-8 , and [TNF-alpha] . Positive_regulation TNF CTR9 1613396 191104 can *augment* [tumor necrosis factor (TNF)] production by human monocytes in a bimodal manner , with two peaks of activation at picomolar and micromolar concentrations . Positive_regulation TNF CTR9 1613396 191109 Moreover , 6 day- or 7 day differentiated HL-60 cells showed a further increase in [TNF] production in *response* to , and the response was bimodal , similar to that of the less dense subset of monocytes , with peaks at 10 ( -14 ) and 10 ( -7 ) M PAF . Positive_regulation TNF CTR9 1668105 176683 *induced* maximal [TNF alpha] synthesis 2-3 hr after monocyte stimulation as assessed by dot blotting of cell associated TNF alpha using polyclonal anti-TNF antibody . Positive_regulation TNF CTR9 16829183 1591445 Both [TNF-alpha] and IL-1beta induced HUVEC platelet activating factor (PAF) production and was *required* for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine ) . Positive_regulation TNF CTR9 17881124 1802338 The data indicate that these three biochemically unrelated classes of inflammatory repressors act synergistically in modulating induced *up-regulation* of COX-2 , [TNFalpha] , and PGE ( 2 ) by quenching oxidative stress or inflammatory signaling , resulting in increased HN cell survival . Positive_regulation TNF CTR9 1873355 165241 Further , the *role* of released in response to a challenge with LPS in the regulation of [TNF] and IL-6 production was investigated . Positive_regulation TNF CTR9 19769579 2258180 Our previous studies have demonstrated that UVB mediated production of keratinocyte [TNF-alpha] is in part *due* to . Positive_regulation TNF CTR9 20116443 2258830 An immediate low release of PGE ( 2 ) was *induced* by PAF , phorbol ester and arachidonic acid but not by IL1beta , [TNF-alpha] and LPS whereas a delayed high release of PGE ( 2 ) was induced by the inflammatory agents IL1beta , TNF-alpha and LPS but not by , phorbol ester and arachidonic acid . Positive_regulation TNF CTR9 20187806 2216114 However , did not *stimulate* the generation of IL-6 , IL-8 , [TNF-alpha] , and MMP-1 to any significant level and in a consistent manner . Positive_regulation TNF CTR9 20423922 2437232 In rats , [TNF-a] increased hydraulic conductivity 2.5-fold over baseline and *increased* it 5-fold ; Positive_regulation TNF CTR9 2133285 150724 Secretion of [TNF] was *detected* shortly after addition of and was dependent on the PAF concentration used . Positive_regulation TNF CTR9 2133285 150729 While biologically active and cytotoxic [TNF] was *detected* early after addition of , the cytotoxic activity declined thereafter though the antigenic activity remained constant . Positive_regulation TNF CTR9 2133286 150734 We have recently shown that can markedly *enhance* the production of [tumor necrosis factor (TNF)] and interleukin-1 (IL-1) by human monocytes stimulated with lipopolysaccharide or muramyl dipeptide ( MDP ) . Positive_regulation TNF CTR9 2230235 144608 The decrease in plasma [TNF alpha] *induced* by or alprazolam was partly reversed by indomethacin . Positive_regulation TNF CTR9 2266661 147295 Inhibitors of PAF synthesis , such as plasma alpha 1-proteinase inhibitor and an anti-inflammatory peptide , blocked changes induced by TNF , PAF receptor antagonists inhibited changes *induced* by and also by [TNF] . Positive_regulation TNF CTR9 2329280 132458 increased cell associated TNF maximally after 2 to 3 h of incubation and *increased* [TNF] release maximally after 5 to 18 h of incubation . Positive_regulation TNF CTR9 2545780 114295 *enhances* [tumor necrosis factor] production by alveolar macrophages . Positive_regulation TNF CTR9 2545780 114305 *Stimulation* of [TNF] production by was blocked by specific , but structurally different PAF receptor antagonists , BN 52021 , CV3988 and WEB 2086 . Positive_regulation TNF CTR9 2545780 114310 Inhibition of 5-lipoxygenase by nordihydro-guaiaretic acid or AA-861 blocked the *induced* augmentation of both [TNF] and LTB4 production . Positive_regulation TNF CTR9 2545780 114322 Collectively , these data suggest that *enhances* [TNF] production by interaction with a specific putative receptor and by subsequent induction of endogenous 5-lipoxygenase activity in AM . Positive_regulation TNF CTR9 7634340 317036 In addition , significantly *enhanced* LPS induced [TNF alpha] production . Positive_regulation TNF CTR9 7683748 216566 It has also been reported , that murine TNF stimulates the production of platelet activating factor (PAF) by cultured peritoneal macrophages , and that *enhances* [TNF] production by alveolar macrophages . Positive_regulation TNF CTR9 7821968 285548 We have shown previously that endotoxin , tumour necrosis factor (TNF) and platelet activating factor (PAF) are important in the pathogenesis of bowel injury , and that endotoxin and [TNF] *induce* formation in bowel tissue . Positive_regulation TNF CTR9 7895533 299757 also *caused* elevated serum [TNF-alpha] in some control mice but not in C3H/HeJ mice . Positive_regulation TNF CTR9 7930608 274729 Despite increasing RNA for the TNF-alpha gene , *increases* [TNF-alpha] protein levels only in the presence of a costimulus , such as PMA . Positive_regulation TNF CTR9 7930608 274734 We also report that *enhances* PMA induced [TNF-alpha] production from human peripheral B cells . Positive_regulation TNF CTR9 8045673 266905 ET-18-O-OCH3 and *stimulated* [TNF alpha] release by resident BALB/c macrophages in the presence of LPS but not in the absence of this co-factor . Positive_regulation TNF CTR9 8045673 266910 In contrast , both ET-18-O_OCH3 and *stimulated* [TNF alpha] release by thioglycollate elicited macrophages in the absence of LPS although release was greater in the presence of this co-stimulus . Positive_regulation TNF CTR9 8080039 270813 Interleukin-1 beta and [tumor necrosis factor-alpha] *induce* production by endothelium , and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist . Positive_regulation TNF CTR9 8088357 271459 Furthermore , [TNF] production *induced* by itself in vitro was also inhibited in the presence of FR128998 . Positive_regulation TNF CTR9 8514698 221951 Repeated dosing also *resulted* in sustained increased serum [tumor necrosis factor-alpha] levels ( 1,610 +/- 470 pg/ml , P < 0.01 ) and further exacerbation of the leukopenia ( -68 +/- 6 % , P < 0.01 ) and thrombocytopenia ( -65 +/- 8 % , P < 0.01 ) . Positive_regulation TNF CTR9 8704099 371130 We have assessed whether *stimulates* IL-6 and [TNF-alpha] production by human bone marrow stromal cells ( mostly fibroblast-like cells ) . Positive_regulation TNF CTR9 9249487 446828 and 2 ) endogenous [TNF-alpha] is not required for LPS mediated induction of iNOS mRNA , and *mediates* LPS induced APH . Positive_regulation TNF CTR9 9394802 468190 These data suggest that , which is released immediately or shortly after LPS injection , *induces* the expression of [TNF-alpha] through the activation of NF-kappa B . Positive_regulation TNF CTSB 11381085 820623 In WEHI-S fibrosarcoma cells , [tumor necrosis factor (TNF)] *induced* an increase in cytosolic activity followed by death with apoptotic features . Positive_regulation TNF CTSB 21318482 2393826 It was found for the first time that [TNF-a] released from PEG-vcTNF-a was specifically *dependent* on the presence of . Positive_regulation TNF CTSB 23314867 2726025 Release of [TNF-a] from rPEG-TNF-a in vitro was *dependent* on the presence of and was inhibited by a cathepsin B inhibitor . Positive_regulation TNF CTSC 7994374 283075 *induced* smaller increases of [TNF] and IL-6 , and a decrease in the levels of IL-1 and GM-CSF . Positive_regulation TNF CTSG 7499869 336102 [TNF-alpha] and PAF alone *induced* modest ( two- to threefold ) increases in cell surface bound , but exhibited a marked dose- and time dependent priming effect for subsequent chemoattractant induced responses ( up to 15- to 25-fold increases in cell surface expression ) . Positive_regulation TNF CTSS 10362800 620149 [TNF-alpha] *induced* , MMP-1 , -3 , and -9 mRNA expression in a dose dependent manner : the maximal effect was observed at a concentration of 10 ng/ml , with appreciable increases observed at concentrations of 0.1 to 1.0 ng/ml . Positive_regulation TNF CUL1 10889302 710426 However , we observed that used as a co-stimulus significantly *potentiated* histamine and [TNF-alpha] release in canine MC activated through Fc epsilon RI regardless of whether or not SCF was added to the medium during culturing . Positive_regulation TNF CUL1 11763385 887883 Moreover , [TNF-alpha] *induced* expression of CD54 by cells in the medium , but not by those retained in the sheets , whereas human induced , dose dependently , expression of CD54 by cells in the sheets , but not from those in the medium . Positive_regulation TNF CUL1 16436136 1516384 Either SCF or [TNF-alpha] could *induce* release from HMC-1 cells of interleukin (IL)-8 , monocyte chemoattractant protein (MCP)-1 , regulated upon activation normal T-cell expressed and secreted ( RANTES ) , and I-309 , while and TNF-alpha induced release of macrophage inflammatory protein (MIP)-1beta and interferon-gamma-inducible protein-10 (IP-10) , respectively . Positive_regulation TNF CUL1 17320132 1719746 In addition , production of [tumor necrosis factor (TNF)-alpha] , interleukin (IL)-1beta , and vascular endothelial growth factor ( VEGF ) production *induced* by was significantly inhibited by treatment with SC-236 . Positive_regulation TNF CUL1 18549896 1923756 In vitro studies using primary mouse hepatocytes show that is *induced* by [TNF-alpha] ; Positive_regulation TNF CUL1 8809429 383143 Changes in the level of mastocytoma mRNA for [TNF alpha] in *response* to stimulation with or fibroblast conditioned media for up to 12 weeks were studied using Northern analysis and changes in the level of TNF alpha protein expression on immunoblot and immunocytochemistry . Positive_regulation TNF CUL1 9637535 513874 was constitutively produced from fibroblasts in its transmembrane form and could be *induced* by [TNF] . Positive_regulation TNF CUL1 9759885 536635 Coligation of SCFR augmented Fc epsilonRI mediated activation of MAP kinases , especially JNK activation , and *augmented* Fc epsilonRI mediated [TNF-alpha] production in MC/9 cells , although SCF alone did not induce TNF-alpha production . Positive_regulation TNF CWC15 22170509 2563285 The *induced* the [tumor necrosis factor-a] production about 1.3 times higher than that of the commercially available ß-1,3/1,6-glucan from baker 's yeast cells . Positive_regulation TNF CWC22 22170509 2563286 The *induced* the [tumor necrosis factor-a] production about 1.3 times higher than that of the commercially available ß-1,3/1,6-glucan from baker 's yeast cells . Positive_regulation TNF CWC25 22170509 2563284 The *induced* the [tumor necrosis factor-a] production about 1.3 times higher than that of the commercially available ß-1,3/1,6-glucan from baker 's yeast cells . Positive_regulation TNF CWC27 22170509 2563283 The *induced* the [tumor necrosis factor-a] production about 1.3 times higher than that of the commercially available ß-1,3/1,6-glucan from baker 's yeast cells . Positive_regulation TNF CX3CL1 10652441 663187 The effects of LPS on [TNF-alpha] secretion were partially *blocked* ( 30 % ) by and the effects of fractalkine were reversed by a polyclonal anti-fractalkine antibody . Positive_regulation TNF CX3CL1 11282163 799120 In vivo neutralization of endogenous brain *increases* hippocampal [TNFalpha] and 8-isoprostane production induced by intracerebroventricular injection of LPS . Positive_regulation TNF CX3CL1 12729461 1106706 [TNF-alpha] activated nuclear factor kappaB (NF-kappaB) and *induced* and CX3CR1 expression in a time dependent manner in rat aortic SMCs . Positive_regulation TNF CX3CL1 12729461 1106723 Taken together , our results demonstrate that [TNF-alpha] *induces* the expression of and CX3CR1 in rat aortic SMCs and that this induction is mediated by NF-kappaB activation . Positive_regulation TNF CX3CL1 15111313 1241126 [Tumor necrosis factor-alpha] *induces* expression preferentially in arterial endothelial cells and mithramycin A suppresses TNF-alpha induced fractalkine expression . Positive_regulation TNF CX3CL1 20089703 2206073 The stimulation of cLP DCs with *increased* the release of IL-6 and [TNF-alpha] . Positive_regulation TNF CX3CL1 20231691 2237850 , a chemokine specific to monocytes and NK cells , is *induced* synergistically by [TNF-alpha] and IFN-gamma in vascular endothelial cells . Positive_regulation TNF CX3CL1 20798528 2313727 [TNF-alpha] significantly *induced* expression in endothelial cells . Positive_regulation TNF CX3CL1 22096344 2010009 Although [tumor necrosis factor (TNF)-a] or interferon ( IFN ) -? alone RA OB *induced* negligible secretion , the combination of TNF-a and IFN-? induced dramatic increases in both soluble CX3CL1 protein and mRNA transcripts . Positive_regulation TNF CX3CR1 12729461 1106707 [TNF-alpha] activated nuclear factor kappaB (NF-kappaB) and *induced* fractalkine and expression in a time dependent manner in rat aortic SMCs . Positive_regulation TNF CX3CR1 12729461 1106724 Taken together , our results demonstrate that [TNF-alpha] *induces* the expression of fractalkine and in rat aortic SMCs and that this induction is mediated by NF-kappaB activation . Positive_regulation TNF CX3CR1 17471309 1731985 In the in vitro culture experiments , IL-10 induced expression on the surface of monocytes , and [TNFalpha] *induced* membrane bound FKN as well as soluble FKN expression in synovial fibroblasts . Positive_regulation TNF CX3CR1 21278339 2392859 Rather , functional was *required* for a subset of tissue bound mononuclear phagocytes to produce [TNF-a] and IL-6 in response to cigarette smoke , and the absence of functional CX3CR1 protected mice from developing tissue-destructive emphysema . Positive_regulation TNF CXADR 18032544 1860776 A selective G ( i ) inhibitor , pertussis toxin (PTX) , but not the inactive B-oligomer binding subunit , abolished *mediated* increases in [TNF] production . Positive_regulation TNF CXCL1 23831863 2839005 In cultured astrocytes , [tumor necrosis factor-a] *induced* robust expression via the activation of the c-jun N-terminal kinase . Positive_regulation TNF CXCL1 24719782 2932014 [TNF] *induced* CCL2 , CCL7 , and in preadipocytes but had no response in adipocytes . Positive_regulation TNF CXCL10 10092813 600788 We found that IFN-gamma , but not [TNF-alpha] or IL-1 beta , strongly *induced* , Mig , and I-TAC mRNA accumulation mainly in NHBEC and that TNF-alpha and IL-1 beta synergized with IFN-gamma induction in all three cell types . Positive_regulation TNF CXCL10 10559511 566631 Ang II and [TNF-alpha] *induced* the expression of ( 1.5 and 3.4-fold ) and MCP-1 ( 2.4 and 4-fold ) in VSMC . Positive_regulation TNF CXCL10 12598219 1062032 In contrast to endotoxin , IA [tumor necrosis factor-alpha] or interleukin-1 alpha did not *induce* or MIG mRNA in the lung . Positive_regulation TNF CXCL10 14597565 1187425 In primary cultured hASM cells taken from normal donors , protein expression was *induced* by IFN-gamma and [TNF-alpha] , cytokines reported as elevated in COPD , and a synergistic response was obtained when they were combined . Positive_regulation TNF CXCL10 15851567 1399546 synthesis is *induced* in HCKs by IL-1alpha , [TNF-alpha] , and IFN-gamma . Positive_regulation TNF CXCL10 15963988 1428205 [TNF-alpha] enhances phenotypic and functional maturation of human epidermal Langerhans cells and *induces* IL-12 p40 and production . Positive_regulation TNF CXCL10 16436136 1516381 Either SCF or [TNF-alpha] could *induce* release from HMC-1 cells of interleukin (IL)-8 , monocyte chemoattractant protein (MCP)-1 , regulated upon activation normal T-cell expressed and secreted ( RANTES ) , and I-309 , while SCF and TNF-alpha induced release of macrophage inflammatory protein (MIP)-1beta and , respectively . Positive_regulation TNF CXCL10 17484771 1778184 LPS induced production of tumour necrosis factor-alpha (TNF-alpha) , interleukin-6 (IL-6) , IL-10 and SA *induced* [TNF-alpha] , and IL-1beta production ; Positive_regulation TNF CXCL10 18370870 1888243 blockade alleviated chronic colitis and *attenuated* the associated increase in serum amyloid A (SAA) , interleukin-12 (IL-12)p40 , [tumor necrosis factor-alpha (TNF-alpha)] , interferon-gamma (IFN-gamma) , IL-1 alpha , and IL-1 beta levels as well as in the number of CD4+ T , NKT , and NK cells that express CXCL10 and CXCR3 , compared with groups treated with control antibody ( Ab ) . Positive_regulation TNF CXCL10 18435806 1908194 We revealed that [TNF-alpha] stimulation *induced* production by HGFs . Positive_regulation TNF CXCL10 18438854 1915451 *stimulated* the expression of RANKL and [tumor necrosis factor alpha (TNFalpha)] in CD4+ T cells and induced osteoclastogenesis in cocultures of CD4+ T cells and osteoclast precursors . Positive_regulation TNF CXCL10 18438854 1915455 However , did not *induce* RANKL or [TNFalpha] in CD8+ T cells . Positive_regulation TNF CXCL10 18760623 1975408 After 48 h , [TNF-alpha] also *induced* a significant increase in IL-1beta , IL-3 , and secretion . Positive_regulation TNF CXCL10 19472212 2102250 These results suggest that [TNF-alpha] *induces* production by activating NF-kappaB through ERK and that IFN-gamma induces CXCL10 production by increasing the activation of STAT1 through JAKs pathways . Positive_regulation TNF CXCL10 19755523 2163448 [TNFalpha] alone *induced* a slight but significant secretion only in PTCs . Positive_regulation TNF CXCL10 19755523 2163455 In fact , a secretion more than ten times higher has been *induced* by [IFNgamma+TNFalpha] in PTCs with respect to TFC . Positive_regulation TNF CXCL10 20062995 2225444 [TNF-alpha] *induced* production of , but not IL-15 in cultured synovial cells from RA patients . Positive_regulation TNF CXCL10 20299237 2254758 In conclusion , IFNalpha , IFNbeta , IFNgamma and [TNFalpha] ( synergistically with IFNs ) dose-dependently *induce* the release of CXCL9 and by TFC , suggesting that this process may be related , at least in part , to the appearance of thyroid dysfunction during IFNs therapy . Positive_regulation TNF CXCL10 21371758 2426549 Significant and dose dependent secretions of were *induced* by IFN-ß but not GA. [TNF-a] synergistically increased IFN-ß induced CXCL10 secretion . Positive_regulation TNF CXCL10 22387292 2593161 Cytomix , IL-1ß , and [TNF-a] *induced* mRNA expression more rapidly in asthmatic than nonasthmatic ASM cells . Positive_regulation TNF CXCL10 22633083 2614810 ( c ) [TNF-a] did not *induce* secretion , in ANA and TFC ; Positive_regulation TNF CXCL10 22944249 2757226 It has been previously shown IFN-a , -ß , -? and [TNF-a] ( synergically with IFNs ) dose-dependently *induce* the release of CXCL9 and chemokines by thyroid follicular cells , suggesting that this process may be related , at least in part , to the appearance of thyroid dysfunction during IFNs therapy . Positive_regulation TNF CXCL11 10092813 600789 We found that IFN-gamma , but not [TNF-alpha] or IL-1 beta , strongly *induced* IP-10 , Mig , and mRNA accumulation mainly in NHBEC and that TNF-alpha and IL-1 beta synergized with IFN-gamma induction in all three cell types . Positive_regulation TNF CXCL11 16847431 1600269 In analogy with TLR ligands , [tumor necrosis factor-alpha (TNF-alpha)] or interleukin-1beta (IL-1beta) , in combination with IFN-gamma , synergistically *induced* CXCL9 and in HMVEC and human fibroblasts , two fundamental cell types delineating the joint cavity . Positive_regulation TNF CXCL11 22944249 2757231 In conclusion , we first show that IFN-a , -ß and -? and [TNF-a] ( synergically with IFNs ) dose-dependently *induce* the release of by primary cultures of human thyroid follicular cells , suggesting that this process may be related to the appearance of thyroid dysfunction during IFNs therapy . Positive_regulation TNF CXCL12 11489936 845468 [TNF-alpha] mediates alpha *induced* NF-kappa B activation and cytotoxic effects in primary astrocytes . Positive_regulation TNF CXCL2 16771850 1572695 In this study , we found that [TNF] and LPS markedly *induced* gene expression in IEC-6 cells , TNF within 30 min , peaking at 45 min , while LPS more slowly , peaking after 2 hr. TNF- and LPS- induced CXCL2 gene expression and protein release were completely blocked by pyrrolidine dithiocarbamate ( PDTC ) and helenalin , two potent NF-kappaB inhibitors . Positive_regulation TNF CXCL5 8961388 402322 To determine whether release was *induced* by [TNF] is this model , rats were treated with neutralizing anti-TNF serum and hepatic ENA-78 levels measured 6 h posthepatectomy . Positive_regulation TNF CXCL5 9164944 432138 GCP-2 is *induced* in MG-63 , but not A549 cells by [TNF-alpha] , IL-1beta , and LPS , while is expressed in both cell types . Positive_regulation TNF CXCL6 19686583 2138957 IL-17 and [TNF-alpha] synergistically *induced* ( GCP-2 ) , IL-6 and receptor activator of NFkappaB ligand ( RANKL ) in MEF . Positive_regulation TNF CXCL6 9164944 432139 is *induced* in MG-63 , but not A549 cells by [TNF-alpha] , IL-1beta , and LPS , while ENA-78 is expressed in both cell types . Positive_regulation TNF CXCL9 10092813 600790 We found that IFN-gamma , but not [TNF-alpha] or IL-1 beta , strongly *induced* IP-10 , , and I-TAC mRNA accumulation mainly in NHBEC and that TNF-alpha and IL-1 beta synergized with IFN-gamma induction in all three cell types . Positive_regulation TNF CXCL9 16847431 1600270 In analogy with TLR ligands , [tumor necrosis factor-alpha (TNF-alpha)] or interleukin-1beta (IL-1beta) , in combination with IFN-gamma , synergistically *induced* and CXCL11 in HMVEC and human fibroblasts , two fundamental cell types delineating the joint cavity . Positive_regulation TNF CXCL9 20299237 2254759 In conclusion , IFNalpha , IFNbeta , IFNgamma and [TNFalpha] ( synergistically with IFNs ) dose-dependently *induce* the release of and CXCL10 by TFC , suggesting that this process may be related , at least in part , to the appearance of thyroid dysfunction during IFNs therapy . Positive_regulation TNF CXCL9 22944249 2757227 It has been previously shown IFN-a , -ß , -? and [TNF-a] ( synergically with IFNs ) dose-dependently *induce* the release of and CXCL10 chemokines by thyroid follicular cells , suggesting that this process may be related , at least in part , to the appearance of thyroid dysfunction during IFNs therapy . Positive_regulation TNF CXCR1 12908082 1150805 Furthermore , the cells did not express receptors including types I and II TNF-alpha receptors , uPA receptor (uPAR) , C-x-C-chemokine receptor-1 (CXCR-1) , or C-C-chemokine receptor-2 , corresponding to [TNF-alpha] , uPA , IL-8 and MCP-1 , respectively , that were *induced* by doxorubicin in the cells , although SBC-7 cells expressed uPAR , and EBC-1 cells expressed . Positive_regulation TNF CXCR2 19864593 2160668 We conclude that is required for RV-induced neutrophilic airway inflammation and that neutrophil [TNF-alpha] release is *required* for airway hyperresponsiveness . Positive_regulation TNF CXXC5 23906331 2830564 Transcription reporter assay and Western blotting showed that *resulted* in activation of [tumor necrosis factor-a (TNF-a)] , initiated the extrinsic apoptosis pathway and cross linked with the intrinsic mitochondrial pathway . Positive_regulation TNF CYBB 15795323 1390310 The aim of this study was to investigate the *role* of containing NADH oxidase signaling in cardiomyocyte [TNF-alpha] expression and myocardial dysfunction induced by LPS . Positive_regulation TNF CYBB 16181054 1461879 Thus , IFN-gamma and [TNF-alpha] *induced* equivalent gene expression in THP-1 cells compared with CM or PBM but did not bring about equivalent NADPH oxidase activity . Positive_regulation TNF CYBB 17197441 1702254 Additionally , [TNF-alpha] *induced* the association of CD11b/CD18 with the NADPH oxidase subunit ( gp91(phox) ) and phosphorylation of p47(phox) , indicating the CD11b/CD18 dependence of NADPH oxidase activation . Positive_regulation TNF CYBB 19318376 2087128 oxidase mediated calpain-1 activation *induces* caspase-3 activation and [TNF-alpha] expression in cardiomyocytes during LPS stimulation . Positive_regulation TNF CYBB 2496143 109646 [Tumor necrosis factor] and immune interferon synergistically *induce* gene expression and nicotinamide-adenine dinucleotide phosphate hydrogenase oxidase in human leukemic myeloid cells . Positive_regulation TNF CYCS 12169276 973771 [TNF] *induced* cleavage of the proapoptotic protein Bid and release of mitochondrial . Positive_regulation TNF CYCS 9824162 549095 This hypothesis is supported by the following observations : ( 1 ) [TNF] and rotenone *induced* MPT and release ; Positive_regulation TNF CYCSP52 24528726 2914866 The bioactivity assays showed that could *increase* the secretions of interleukin-1ß (IL-1ß) , [tumor necrosis factor-a (TNF-a)] , macrophage inhibitory protein-1a ( MIP-1a ) , macrophage inhibitory protein-1ß ( MIP-1ß ) , and RANTES ( regulated on activation , normal T cell expressed and secreted ) in human peripheral blood mononuclear cells ( PBMCs ) , which play critical roles in the innate immune system and shape the adaptive immunity . Positive_regulation TNF CYP19A1 20186112 2216090 Potential target areas which may be attractive alternatives to current therapies are also reviewed and include inhibitors , angiogenesis disruptors and [anti-tumor necrosis factor-alpha] *inhibitors* . Positive_regulation TNF CYP1A1 19570565 2111203 The organic fraction was examined for PAH content , direct mutagenicity , *induction* , and cytotoxicity and [TNF-alpha] release in RAW264.7 macrophages . Positive_regulation TNF CYP2E1 16175602 1461837 In conclusion , forced overfeeding with a high-fat diet in mice induces obesity , insulin resistance , and SH in the absence of [TNF] signaling or *induction* . Positive_regulation TNF DAB2IP 12813029 1103099 exists in a closed form through an intramolecular interaction between the N-terminus and the C-terminus , and [TNF-alpha] *induces* unfolding of AIP1 leading to association of AIP1 with ASK1 . Positive_regulation TNF DAB2IP 17389591 1735571 In the present study , we show that a TNF-inducible 14-3-3 binding site on AIP1 is critical for the opening of its conformation and for the *mediated* [TNF] signaling . Positive_regulation TNF DAB2IP 18292600 1891527 Endogenous complex can be detected in the resting state , and [TNF] *induces* a complex formation of AIP1-PP2A with ASK1 . Positive_regulation TNF DAP 24766550 2956074 The level of cytokines [interleukin-6 ( IL-6 ) and [tumour necrosis factor-a (TNF-a)] ] and chemokines ( CXCL1 and CCL2 ) was *increased* by MDP , but not in wild-type ( WT ) neutrophils . Positive_regulation TNF DAPK1 22465880 2588967 Both [TNF-a] and INF-? significantly *induce* levels in a time dependent manner . Positive_regulation TNF DAPK1 22465880 2588971 In the *presence* of , [TNF-a] or INF-? induced apoptosis was additively increased , while TNF-a or INF-? induced NF-?B activity was inhibited . Positive_regulation TNF DAPK1 22465880 2588977 Taken together , our data findings suggest that can *mediate* the pro-apoptotic activity of [TNF-a] and INF-? via the NF-?B signaling pathways . Positive_regulation TNF DCTN3 11244505 792320 Here , we show that in HeLa cells [TNFalpha] *induces* expression of in an NF-kappaB dependent fashion . Positive_regulation TNF DDB2 15700318 1388706 Moreover , overexpression of in HR18 cells also *attenuated* [TNF-alpha] induced caspase activation . Positive_regulation TNF DDC 10788575 688928 alone did not *stimulate* the release of NO and [TNF-alpha] by Kupffer cells . Positive_regulation TNF DDC 10788575 688929 Interestingly , when Kupffer cells were stimulated by lipopolysaccharide (LPS) , ( 0-30 microM ) *enhanced* the production of both NO and [TNF-alpha] in a concentration dependent manner . Positive_regulation TNF DDC 10788575 688934 These findings demonstrate that *enhances* the production of NO and [TNF-alpha] by LPS stimulated Kupffer cells and suggest that protein kinase C plays a critical role in mediating these effects of DDC . Positive_regulation TNF DDC 24557113 2919276 The present study demonstrated that ( 1 ) systemic *induced* upregulation of [TNF-a] , SDF1-a , and CXCR4 in both the lumbar spinal cord and the L4/5 DRG ; Positive_regulation TNF DDC 24557113 2919279 and ( 4 ) HSV vector expressing p55TNFSR reversed upregulation of [TNF-a] , SDF1-a , and CXCR4 *induced* by in the lumbar spinal dorsal horn and the DRG . Positive_regulation TNF DDIT3 17911345 1830182 [TNFalpha] *induced* rat preadipocyte expression . Positive_regulation TNF DDIT3 24080827 2847610 Simultaneous silencing of ATF4 and *prevented* upregulation of [TNF-a] . Positive_regulation TNF DDIT3 24080827 2847612 Our data therefore revealed a role of ER stress and in the ethanol induced inhibition of osteogenesis , and *activation* of [TNF-a] signaling by ATF4/CHOP linking ER stress to adipogenic lineage in response to alcohol stimulation . Positive_regulation TNF DDT 15603917 1356822 Taken together , these data demonstrate *induces* both the expression of the death ligand [TNF-alpha] and apoptosis through a p38 MAPK dependent mechanism . Positive_regulation TNF DDT 18755234 1975292 Further , *induced* the significant ( p < 0.05 ) production of [tumor necrosis factor-alpha (TNF-alpha)] and nitric oxide ( NO ) in macrophages and thus contributes inflammatory reactions , cytokine imbalance and immune-dysregulation . Positive_regulation TNF DDX39B 18381799 1907073 The *role* of in the regulation of [tumor necrosis factor-a] suggests that BAT1 may regulate the inflammatory response observed in patients with RA . Positive_regulation TNF DDX58 18523264 1922805 Interference of RIG-I expression short interfering RNA represses the expression of LPS induced TNF-alpha , whereas over-expression of *leads* to the activation of [TNF-alpha] promoter and the induction of TNF-alpha expression . Positive_regulation TNF DDX58 22013225 2503314 We show that the innate sensing receptor is *involved* in interferon regulatory factor 3 (IRF3) , NF-?B nuclear translocation , p38 activation , and the subsequent interferon ( IFN ) ß , IFN-?1 , and [tumor necrosis factor] a induction during H5N1 infection . Positive_regulation TNF DDX58 22391244 2566589 In human keratinocytes , is *induced* by IFN-? and [tumor necrosis factor-a] stimulation , and is abundantly expressed in psoriatic keratinocytes of the spinous and basal layers . Positive_regulation TNF DEFA1 17321471 1706325 The selective A ( 2A ) receptor antagonist ZM241385 ( 30 nM ) , but not the selective A ( 2B ) receptor antagonist ( 30 nM ) , *blocked* the inhibitory effect of NECA and CGS21680 on [TNF-alpha] release . Positive_regulation TNF DEFA1 19841638 2209527 The A2b receptor antagonist was able to *increase* the production of IL-12p70 and [TNF-alpha] by hypoxic mDCs and elevate the amount of Th1 cytokine IFN-gamma production in a mDCs-T-cell co-culture system . Positive_regulation TNF DEFA1B 1421280 202108 It was shown that TNF-alpha production by human monocytes activated by SAC or PMA was augmented in the presence of HNP-1 concentrations of 10 ( -8 ) -10 ( -9 ) M . alone *induced* no synthesis of [TNF-alpha] . Positive_regulation TNF DEFA1B 18787642 1969330 Mechanistically , HBP and *triggered* macrophage release of [TNF-alpha] and IFN-gamma , which acted in an autocrine loop to enhance expression of CD32 and CD64 and thereby enhance phagocytosis . Positive_regulation TNF DEFA1B 19477909 2142267 Both defensins promoted the activation and maturation of moDCs , as assessed by up-regulation of surface expression of the costimulatory molecules CD80 , CD86 , and CD40 , the maturation marker CD83 , and HLA-DR . and HBD-1 also *enhanced* the production of the proinflammatory cytokines [TNF-alpha] , IL-6 , and IL-12p70 but did not affect the production of the regulatory cytokine IL-10 . Positive_regulation TNF DEFB103B 16101361 1444258 In addition to the published observations ( PMA induces hBD-2 and -4 ; [TNF-alpha] *induces* ) , it was found that PMA can upregulate hBD-1 and hBD-3 , whereas TNF-alpha can induce hBD-4 . Positive_regulation TNF DEFB104B 16101361 1444256 In addition to the published observations ( PMA induces hBD-2 and -4 ; TNF-alpha induces hBD-2 and -3 ) , it was found that PMA can upregulate hBD-1 and hBD-3 , whereas [TNF-alpha] can *induce* . Positive_regulation TNF DEFB4B 10837369 699392 Mucoid Pseudomonas aeruginosa , [TNF-alpha] , and IL-1beta , but not IL-6 , *induce* human in respiratory epithelia . Positive_regulation TNF DEFB4B 16101361 1444257 In addition to the published observations ( PMA *induces* and -4 ; [TNF-alpha] induces hBD-2 and -3 ) , it was found that PMA can upregulate hBD-1 and hBD-3 , whereas TNF-alpha can induce hBD-4 . Positive_regulation TNF DFFA 23229555 2736631 Interestingly , expression of DNAS1L3 in ICAD-deficient cells failed to promote [tumor necrosis factor] a-induced INDF but *required* the coexpression of . Positive_regulation TNF DGAT1 16956609 1615747 Activation of gene *results* in increased [tumor necrosis factor-alpha] gene expression in 3T3-L1 adipocytes . Positive_regulation TNF DHX9 15355351 1293082 In transient transfection assays , *enhanced* NF-kappaB dependent reporter gene expression induced by p65 , [tumor necrosis factor-alpha] , or NF-kappaB inducing kinase . Positive_regulation TNF DKC1 15020249 1221499 [TNFalpha] *induces* rapid activation and nuclear translocation of in human lymphocytes . Positive_regulation TNF DKC1 15326480 1296848 The present study described that , in the leukemic KG1 cells , [TNFalpha] *induced* no apoptosis but a senescence state characterized by prolonged growth arrest , increased beta-galactosidase activity , p21WAF-1 induction , decreased activity , telomeric disturbances ( shortening , losses , fusions ) , and additional chromosomal aberrations . Positive_regulation TNF DNAJC5 23806004 2815603 Specifically , the high-molecular weight sub-fraction ( average of 38.5 kDa ) *induced* NO and cytokine [interleukin ( IL ) -1a , -1ß , -6 , -10 , [tumor necrosis factor] ( TNF ; designated previously as TNF-a ) , and granulocyte macrophage-colony stimulating factor ( GM-CSF ) ] production by human peripheral blood mononuclear cells ( PBMCs ) and monocyte/macrophages . Positive_regulation TNF DNAJC5 23806004 2815660 *induced* secretion of [TNF] was prevented by Toll-like receptor 4 (TLR4) antagonist LPS-RS , indicating a role for TLR4 signaling . Positive_regulation TNF DNTT 21514428 2418732 Diabetic A ( 2A ) AR ( -/- ) mice had significantly more *mediated* dUTP nick-end labeling positive cells , [TNF-a] release , and intercellular adhesion molecule-1 expression compared with diabetic wild-type mice . Positive_regulation TNF DPP4 15614194 1387628 We analyzed reactive oxygen intermediate ( ROI ) production by peripheral blood granulocytes , the production of IL-2 , IL-5 , IL-10 , IL-12 , and [TNF-alpha] cytokines by lymphocytes , and the *activation* of CD25 , , CD69 , CD71 , and HLA DR antigen expression . Positive_regulation TNF DPYD 23301483 2712527 Compared with EATD group , the level of and Ca/Cr in the other three EA groups had no statistical differences ( all P > 0.05 ) , but the level of ALP , BGP , [TNF-alpha] and ICTP in serum *increased* significantly ( all P < 0.01 ) , the level of E2 and PICP in serum decreased significantly ( all P < 0.01 ) . Positive_regulation TNF DPYS 15661163 1365056 Interestingly , we demonstrate that Tat induced calcium mobilization is tightly linked to TNF-alpha production , thus indicating that Tat induced mobilization and [TNF-alpha] production are entirely *mediated* by receptors , as shown by their total inhibition by nimodipine , calcicludine , or anti-alpha1D antisense oligonucleotides . Positive_regulation TNF DST 11859116 914754 In contrast , IL-1alpha , IL-1beta , [TNF-alpha] , IFN-gamma-inducible protein-10 , and Th2 cytokines such as IL-4 and IL-10 did not *induce* . Positive_regulation TNF DST 19769995 2158975 We also showed that *increased* significantly the [tumor-necrosis factor alpha (TNF-alpha)] gene expression and protein excretion as measured by real-time RT-PCR and ELISA luminescent test , respectively . Positive_regulation TNF DST 19769995 2158977 Moreover , we observed that induction of AK activation and [TNF-alpha] gene expression *require* lower levels of than apoptosis or TNF-alpha protein excretion . Positive_regulation TNF DST 20131228 2219906 [TNFalpha] *induced* RA synovial fibroblast and IL-18 in a time dependent manner ( P < 0.05 ) . Positive_regulation TNF DST 20131228 2219909 Evaluation of signaling pathways suggested that [TNFalpha] *induced* IL-18 production through the ERK-1/2 , protein kinase Cdelta (PKCdelta) , and Src pathways , whereas synthesis was mediated through the NFkappaB , PKC , Src , and JNK pathways . Positive_regulation TNF DST 21783458 1506624 We investigated the effects of BPA exposure on the activities of murine peritoneal macrophages through evaluation of *induced* alteration of nitric oxide ( NO ) production , [tumor necrosis factor-a (TNF-a)] synthesis , and expression of co-stimulatory molecules B7 . Positive_regulation TNF DUOX1 24406179 2884139 [TNF-a] can *induce* expression increasing in lipid raft , then the DUOX-1 can be activated to increase reactive oxygen species level ; Positive_regulation TNF DUSP1 11137629 769996 In contrast , [TNF-alpha] *induces* expression in PC12 cells and does not alter MKP-1 expression in HeLa cells . Positive_regulation TNF DUSP1 11137629 769998 Both bpV ( phen ) and [TNF-alpha] *induce* expression in OVCAR-3 cell line but with different dynamics : TNF-alpha causes transient and bpV ( phen ) sustained induction of MKP-1 expression . Positive_regulation TNF DUSP1 15485842 1347350 Overexpression of substantially *attenuated* the production of [tumor necrosis factor (TNF)-alpha] induced by peptidoglycan , whereas knockdown of MKP-1 by small interfering RNA substantially increased the production of both TNF-alpha and interleukin-1 beta . Positive_regulation TNF DUSP1 15485842 1347351 Our results reveal that critically *regulates* the expression of [TNF-alpha] and interleukin-1 beta in RAW264.7 cells and further suggest a central role for this phosphatase in controlling the inflammatory responses of primary macrophages to Gram positive bacterial infection . Positive_regulation TNF DUSP1 15614136 1357483 We hypothesized that expression induced during tolerance *regulates* [TNF-alpha] expression by inhibiting p38 activity . Positive_regulation TNF DUSP1 16109884 1474089 HIV nef protein was sufficient to reduce [TNF-alpha] release and *induce* in healthy macrophages . Positive_regulation TNF DUSP1 17507666 1778268 Since kinase activity is tightly regulated by phosphatases , we hypothesized that the dual specificity phosphatase *regulates* p38 activity and [TNF-alpha] production in alveolar macrophages due to insufficient H ( 2 ) O ( 2 ) generation in response to asbestos . Positive_regulation TNF DUSP1 18441094 1932696 In HASM cells , dexamethasone and [TNF-alpha] *induced* expression ( both mRNA and protein ) rapidly . Positive_regulation TNF DUSP10 22683306 2633396 Also , deficiency markedly *inhibited* the production of [TNF-a] , but enhanced the levels of TGF-ß1 in ox-LDL stimulated macrophages . Positive_regulation TNF DUSP14 23229544 2724460 The dual-specificity phosphatase negatively *regulates* [tumor necrosis factor-] and interleukin-1 induced nuclear factor-?B activation by dephosphorylating the protein kinase TAK1 . Positive_regulation TNF DUSP14 23229544 2724463 These findings suggest that negatively *regulates* [TNF-] or IL-1 induced NF-?B activation by dephosphorylating TAK1 at Thr-187 . Positive_regulation TNF DUSP6 18314537 1919426 Asbestos induced expression *augments* [TNF-alpha] gene expression in human monocytes . Positive_regulation TNF DYNLRB1 12709026 1083024 The expression of TLR2 protein by hepatocytes was also remarkably *up-regulated* by IL-1alpha and , to a lesser extent , by [TNF-alpha] as well , but not by LPS or . Positive_regulation TNF DYNLRB1 16461741 1540837 When compared with nontolerant human monocytic THP-1 cells , BLP-tolerant cells had a significant reduction in [tumor necrosis factor alpha (TNF-alpha)] production in *response* to a high-dose ( 86+/-12 vs. 6042+/-245 ng/ml , P < 0.01 ) or LPS ( 341+/-36 vs. 7882+/-318 ng/ml , P < 0.01 ) stimulation . Positive_regulation TNF DYNLRB1 16849509 1588495 Remarkably , newborn blood plasma confers substantially reduced *induced* monocyte synthesis of [TNF-alpha] , while preserving IL-6 synthesis , reflecting the presence in neonatal blood plasma of a soluble , low molecular mass inhibitory factor ( < 10 kDa ) that we identify as adenosine , an endogenous purine metabolite with immunomodulatory properties . Positive_regulation TNF DYNLRB1 18675993 2011265 The role of P38 MAPK and PKC in *induced* [TNF-alpha] release , apoptosis , and NFkappaB activation in THP-1 monocyte cells . Positive_regulation TNF DYNLRB1 21549062 2429209 In control group stimulation ( 10 , 100 , 1 000 ng/ml ) could *induce* THP-1 activation and [TNF-a] production ( pg/ml : 184.86±32.51 , 3 215.88±167.09 , 6 042.96±245.37 ) in a dose dependent manner . Positive_regulation TNF DYNLRB1 22003201 2503214 Priming of human monocytes or PBMCs with superantigens significantly enhanced proinflammatory cytokine [TNF-a] and IL-6 release in *response* to stimulation . Positive_regulation TNF EAF1 10736094 679349 Using neutralization with an anti TNF-alpha MoAb MAK195 , is not identical with TNF-alpha , but *induces* the expression of endothelial [TNF-alpha] , since MAK195 blocked TEM only when coincubated with EC , not with monocytes . Positive_regulation TNF EAF2 10736094 679350 Using neutralization with an anti TNF-alpha MoAb MAK195 , is not identical with TNF-alpha , but *induces* the expression of endothelial [TNF-alpha] , since MAK195 blocked TEM only when coincubated with EC , not with monocytes . Positive_regulation TNF ECE1 11775854 581306 [TNF-alpha] *induced* expression and ET-1 release from above cultured cells were determined by RT-PCR and ELISA . Positive_regulation TNF ECH1 11739521 886554 also *induced* high levels of [TNF-alpha] ( 900 pg/ml ) in human monocytes comparable to native SD flagellin ( 991.5 pg/ml ) and 6HIS flag ( 987 pg/ml ) . Positive_regulation TNF EDA 14687926 1190276 For in vitro experiments , Kupffer cells were cultured in the presence of 0-270 microM GdCl for 24h following which viability , [TNFalpha] protein production in *response* to LPS ( 10 ng/ml ) , phagocytosis , and and ED2 staining were evaluated . Positive_regulation TNF EDA 17202335 1680911 also *stimulated* the production by DC of proinflammatory cytokines such as IL-12 or [TNF-alpha] and induced their maturation in vitro and in vivo . Positive_regulation TNF EDA 21193170 2414246 These findings suggest that ( + ) cells are *involved* in the expression of [TNF-a] and IL-1ß and the subsequent regulation of bone resorption on pressure side . Positive_regulation TNF EDA 8807501 382800 We report results here that show that treatment of the macrophage-like cell line RAW 264.7 with the extract *results* in an increase in the production of both interleukin-6 (IL-6) and [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF EDIL3 15964546 1428221 In addition , mouse recombinant interleukin-1alpha and [tumor necrosis factor-alpha] also *induced* in MLE cells . Positive_regulation TNF EDN1 10198220 605099 The results suggest that chronic alcohol ingestion exerts detrimental effects on the buccal mucosal IL-4 expression , causing dysregulation of production , *induction* of [TNF-alpha] , and triggering apoptotic events that delay the mucosal repair . Positive_regulation TNF EDN1 10708710 673593 The p55 [tumor necrosis factor] receptor ( CD120a ) *induces* synthesis in endothelial and epithelial cells . Positive_regulation TNF EDN1 10708710 673596 Synthesis of the vasoconstrictor peptide by endothelial and epithelial cells is strongly *induced* by [tumor necrosis factor alpha (TNF-alpha)] . Positive_regulation TNF EDN1 11775854 581305 To explore the mechanism of [TNF-alpha] *induced* release and evaluate the effects of endothelin converting enzyme (ECE) antisense oligonucleotides ( oDNS ) on TNF-alpha induced ET-1 release from airway smooth muscle cells ( ASMC ) . Positive_regulation TNF EDN1 11775854 581308 Abnormal expression of ECE mRNA may be a keypoint responsible for [TNF-alpha] *induced* release in human ASMC ; Positive_regulation TNF EDN1 11775854 581313 [TNF-alpha] *induced* release and ECE mRNA expression from human ASMC are inhibited by antisense oligonucleotide of ECE . Positive_regulation TNF EDN1 11899142 894244 These findings suggest that the increased secretion of leading to enhanced pigmentation in SK results from the co-ordinated *increased* expression of [TNF-alpha] and ECE-1alpha . Positive_regulation TNF EDN1 11994508 939097 and -3 *induced* the release of beta-hexosaminidase and [TNF] and of mRNA expression . Positive_regulation TNF EDN1 14715521 1197334 Exogenous *increased* [TNF-alpha] levels and triggered HPS after PVL . Positive_regulation TNF EDN1 15214039 1262829 Furthermore , *induced* [TNF-alpha] and IL-6 production by FSMC , but not by BMMC , and significantly enhanced VEGF production and TGF-beta1 mRNA expression by FSMC . Positive_regulation TNF EDN1 15652492 1364236 [TNF-alpha] *induces* interleukin-8 and expression in human endothelial cells with different redox pathways . Positive_regulation TNF EDN1 15652492 1364252 Thus , [TNF-alpha] significantly *induces* both IL-8 and gene expression in HMECs possibly through different redox signaling pathways . Positive_regulation TNF EDN1 1566813 186856 We found that [TNF-alpha] *induced* release of from bovine aortic endothelial cells ( BAEC ) in a time- and concentration dependent manner . Positive_regulation TNF EDN1 16596276 1544875 We suggested that [TNF-alpha] can *induce* mRNA expression in NSCLC , similarly to IL-8 expression . Positive_regulation TNF EDN1 18475471 209536 [TNF-alpha] *induced* gene expression was associated with a parallel increase in the release of the corresponding peptide in the culture medium . Positive_regulation TNF EDN1 18991099 1983846 The production of ET-1 by MDDCs was negligible in all examined conditions , while the release of [TNFalpha] and IL-12 was *stimulated* by LPS but not by . Positive_regulation TNF EDN1 19850966 2170302 expression was *induced* by [TNFalpha] and by ET-1 itself . Positive_regulation TNF EDN1 21357287 2404166 Preeclampsia is associated with innate inflammatory response resulting in elevated [tumor necrosis factor-a] , agonistic autoantibodies to the angiotensin II type I receptor , and *activation* of . Positive_regulation TNF EDN1 22290536 2740061 In fact , cAMP inhibited *stimulated* [TNF-a] and IL-1ß expressions in adipocytes . Positive_regulation TNF EDN1 22956308 2726592 As [TNF-a] also increases ADM levels in the epididymal fat and the soleus muscle and also *increases* ADM levels in the epididymal fat , they may form a feedback loop with ADM in these tissues . Positive_regulation TNF EDN1 8719812 343908 4. These data suggest that [TNF-alpha] may *induce* the release of and that this mediates at least part of the coronary vasoconstriction . Positive_regulation TNF EDN1 8757219 377688 The release of fibronectin and [tumor necrosis factor-alpha] *induced* by was studied in alveolar macrophages by enzyme immunoassay . Positive_regulation TNF EDN1 8757219 377694 significantly *increased* the release of [tumor necrosis factor-alpha] and fibronectin by alveolar macrophages from normal subjects and patients with stable asthma , but it significantly decreased their release in patients with unstable asthma . Positive_regulation TNF EDN1 9687319 522188 Also , [TNFalpha] and IL-1beta *induced* further release of stimulated by LH ( p < 0.05 ) . Positive_regulation TNF EDN2 10750028 681329 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone , indicating that adenylate cyclase and [TNFalpha] *induce* synthesis by separate signalling pathways . Positive_regulation TNF EDN2 8757219 377689 The release of fibronectin and [tumor necrosis factor-alpha] *induced* by was studied in alveolar macrophages by enzyme immunoassay . Positive_regulation TNF EDN2 8757219 377695 significantly *increased* the release of [tumor necrosis factor-alpha] and fibronectin by alveolar macrophages from normal subjects and patients with stable asthma , but it significantly decreased their release in patients with unstable asthma . Positive_regulation TNF EDN3 11994508 939098 *induced* the release of beta-hexosaminidase and [TNF] and of mRNA expression . Positive_regulation TNF EDN3 8757219 377690 The release of fibronectin and [tumor necrosis factor-alpha] *induced* by was studied in alveolar macrophages by enzyme immunoassay . Positive_regulation TNF EDN3 8757219 377696 significantly *increased* the release of [tumor necrosis factor-alpha] and fibronectin by alveolar macrophages from normal subjects and patients with stable asthma , but it significantly decreased their release in patients with unstable asthma . Positive_regulation TNF EDNRA 10229544 611046 These findings suggest that *regulates* [TNF] production in murine lung by suppressing LPS receptor expression , mRNA expression and protein synthesis and/or secretion of TNF . Positive_regulation TNF EDNRA 11112424 757617 Overexpression of PKC *delayed* the activation of caspase-8 and -7 by both [TNF] and the combination of BIM and TNF . Positive_regulation TNF EDNRA 11854220 913519 did not *induce* [TNF-alpha] and was a weak inducer of IL-1 beta , IL-6 , macrophage inflammatory protein 1 alpha ( MIP-1 alpha ) , and MIP-2 . Positive_regulation TNF EDNRA 1286882 207657 In contrast to LPS , *induced* only low amounts of IL-6 and no detectable [TNF] activities in peritoneal macrophage supernatants . Positive_regulation TNF EDNRA 12906870 1119170 The cytokine production and the expression of [tmb-TNF-alpha] were measured in the *presence* of . Positive_regulation TNF EDNRA 8500881 220932 Purified did not *stimulate* the production of [TNF] in normal mice primed with a synthetic derivative of muramyl dipeptide in the absence of endotoxin . Positive_regulation TNF EDNRA 9444616 475301 The generation of [TNF alpha] caused by ET-1 *involves* ( in sequence ) the ( i ) activation of , ( ii ) activation of tyrosine kinase resulting in the phosphorylation of intracellular proteins , ( iii ) the activation of , hitherto , unknown transcription factors , finally resulting in ( iv ) transcription and translation of the TNF alpha gene . Positive_regulation TNF EEF1A2 15364922 1334180 Finally , PD98089 , a compound that blocks activation of extracellularly regulated kinases1/2 , suppressed *induced* up-regulation of [tumor necrosis factor-alpha] but had little effect on microglial transformation . Positive_regulation TNF EFNA1 11278471 802581 Although [TNF-alpha] *induces* expression in endothelial cells , the signaling pathways mediating ephrin A1 induction remain unknown . Positive_regulation TNF EGF 11460304 838800 Moreover , [TNF-alpha] increased viral replication in the *presence* of but not TGF-alpha . Positive_regulation TNF EGF 1512472 196694 Human ( hu ) recombinant ( r ) [tumor necrosis factor (TNF)-alpha] and interferon (IFN)-gamma *induced* receptor and TGF-alpha expression by keratinocytes as determined by immunohistochemistry . Positive_regulation TNF EGF 1577791 187537 [Tumor necrosis factor] *increases* transcription of the heparin binding growth factor gene in vascular endothelial cells . Positive_regulation TNF EGF 17760721 1790131 Moreover , the methylation was induced by [TNFalpha] , MG132 , and EGF treatment , and DNA methyltransferase activity was *induced* by treatment in MKN-1 cells . Positive_regulation TNF EGF 21908587 2511246 First , we discerned that [TNF-a] *induced* metalloproteinase-9 release , shedding , and subsequent EGF receptor transactivation . Positive_regulation TNF EGF 23800251 2807999 The chemokine network revealed that ovarian cancer cells commonly expressed high levels of proinflammatory chemokines such as CCL20 , CXCL1-3 and CXCL8 in *response* to or [TNF] . Positive_regulation TNF EGF 8349617 227077 Expression of keratinocyte SL-2 was also *induced* by the two keratinocyte growth factors , transforming growth factor-alpha and , by the proinflammatory cytokine , [tumor necrosis factor-alpha] , but , somewhat surprisingly , not by interleukin-1 beta . Positive_regulation TNF EGFR 11337489 827569 We also have shown that [TNF] *induces* tyrosine phosphorylation and internalization of the overexpressed EGFR in NIH3T3 cells and the endogenously expressed in A431 cells and that the transactivation by TNF is suppressed by N-acetyl-l-cysteine or overexpression of an endogenous reducing molecule , thioredoxin , but not by phosphatidylinositol 3-kinase inhibitors and protein kinase C inhibitor . Positive_regulation TNF EGFR 12469217 1032570 Also , [TNF-alpha] did not *induce* expression at the protein level . Positive_regulation TNF EGFR 16777389 1573104 On the other hand , the PI3-K inhibitor , LY294002 , and inhibitor , AG1478 , did not *suppress* the release of [TNF-alpha] . Positive_regulation TNF EGFR 17148666 1661543 In primary cultures of human gallbladder epithelial cells , [TNF-alpha] *induced* overexpression . Positive_regulation TNF EGFR 17934341 1813463 Genistein , a protein tyrosine kinase (PTK) inhibitor , and PD153035 , an EGFR inhibitor , also blocked the increase of TNF-alpha expression by TCDD , indicating the *role* of in TCDD induced [TNF-alpha] expression . Positive_regulation TNF EGFR 17934341 1813476 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of and ERK , but not c-Src , JNK , nor p38 MAPK . Positive_regulation TNF EGFR 21566012 2458886 We hypothesized that COX-2 induction and cell survival signaling downstream of [TNF] are *mediated* by transactivation . Positive_regulation TNF EGFR 22301110 2580339 [TNF-a] *induces* upregulation of expression and signaling in human colonic myofibroblasts . Positive_regulation TNF EGFR 2482293 122780 [TNF] *activation* of kinase activity in ME-180 was measurable 10 min after TNF incubation and enzymatic activity remained elevated 20 min after TNF addition . Positive_regulation TNF EGFR 9162524 389375 *Activation* of tyrosine phosphorylation by [tumor necrosis factor] correlates with loss of cytotoxic activity . Positive_regulation TNF EGLN2 19762779 2163498 Downregulation of or Phd2 mRNA by RNA interference partially *attenuated* LPS induced [TNF-alpha] induction . Positive_regulation TNF EGLN3 22948157 2697695 Here , we show that in NP cells , [TNF-a] and IL-1ß *induce* expression through NF-?B . Positive_regulation TNF EGR1 10913190 716209 The transcription factors ATF-2 , c-jun , , and Sp1 are also inducibly recruited to the TNF-alpha promoter in vivo , and the binding sites for each of these activators are *required* for LPS stimulated [TNF-alpha] gene expression . Positive_regulation TNF EGR1 11520792 852347 The data indicate that LPS induction of gene expression is *required* for maximal induction of the [TNF-alpha] and TF genes in human monocytic cells . Positive_regulation TNF EGR1 11586099 866405 In this trial , the radiation activated promoter *regulates* expression of the [tumor necrosis factor] alpha gene , which is administered by use of the attenuated adenovirus vector . Positive_regulation TNF EGR1 11689211 876130 [TNFalpha] *induces* expression of transcription factors c-fos , , and Ets-1 in vascular lesions through extracellular signal regulated kinases 1/2 . Positive_regulation TNF EGR1 11689211 876139 In cultured RAW 264.7 mouse macrophages , [TNFalpha] similarly *induced* the expression of Ets-1 , , and c-fos . Positive_regulation TNF EGR1 11751152 898186 ERK1/2 and *contribute* to increased [TNF-alpha] production in rat Kupffer cells after chronic ethanol feeding . Positive_regulation TNF EGR1 11751152 898189 Together , these data suggest that enhanced activation of ERK1/2 and *contributes* to increased [TNF-alpha] production after chronic ethanol feeding . Positive_regulation TNF EGR1 11856733 929520 Overexpression of dominant negative *prevented* the ethanol induced increase in LPS stimulated [TNFalpha] mRNA accumulation . Positive_regulation TNF EGR1 11856733 929523 These results demonstrate that enhanced LPS dependent activation of *contributes* to increased [TNFalpha] production after chronic ethanol exposure . Positive_regulation TNF EGR1 12734378 1087353 Our results indicate that A beta induced expression of cytokines ( [TNF-alpha] and IL-1 beta ) and chemokines ( MCP-1 , IL-8 , and MIP-1 beta ) in THP-1 monocytes *involves* activation of ERK-1/ERK-2 and downstream activation of . Positive_regulation TNF EGR1 14525948 1174390 We also investigated the possible involvement of Egr-1 , which regulates PTEN in some cells ( e.g. , fetal kidney epithelial cells ) , and [TNF-alpha] , which can *induce* expression . Positive_regulation TNF EGR1 15149634 1248414 IL-1 and [TNF-alpha] *induced* and all AP-1 member expression , except fosB and junD . Positive_regulation TNF EGR1 15940638 1415589 , an immediate early gene/zinc-finger transcription factor , is *required* for maximal stimulation of [tumor necrosis factor alpha (TNF-alpha)] transcription in response to lipopolysaccharide (LPS) . Positive_regulation TNF EGR1 15940638 1415590 Because chronic ethanol exposure sensitizes macrophages to LPS stimulated TNF-alpha expression , we have investigated the *role* of in mediating increased LPS stimulated [TNF-alpha] expression after chronic ethanol feeding . Positive_regulation TNF EGR1 15940638 1415592 These data show that *contributes* to increased LPS mediated [TNF-alpha] expression after chronic ethanol and that the absence of Egr-1 prevents chronic ethanol induced fatty liver , as well as increased sensitivity to LPS . Positive_regulation TNF EGR1 18088351 1868592 These observations suggest that AT might *inhibit* LPS induced production of [TNF-alpha] by inhibiting the increase in expression in monocytes via interaction with heparin-like substances expressed on the cell surface . Positive_regulation TNF EGR1 18227157 1884327 It was shown that these three proteins could ( i ) induce expression of [tumor necrosis factor alpha (TNF-alpha)] and tissue factor and ( ii ) *induce* phosphorylation of p44/42 mitogen activated protein kinases (MAPK) and activation of . Positive_regulation TNF EGR1 18227157 1884380 Treatment of cells with a MEK1/2 inhibitor , U0126 , dramatically reduced the phosphorylation of ERK , *activation* of , and expression of [TNF-alpha] in macrophages treated with recombinant proteins . Positive_regulation TNF EGR1 20653771 2293316 Up-regulation of [TNF-alpha] secretion by cigarette smoke is *mediated* by in HaCaT human keratinocytes . Positive_regulation TNF EGR1 7585181 333655 and 5,000 cGy ( rad ) *resulted* in increased intratumoral [TNF-alpha] production and increased tumour control compared with treatment with Ad5 . Positive_regulation TNF EGR1 9407088 470838 *Induction* of the [TNF-alpha] gene by ionizing radiation and was mediated via a GC-rich EGR-1 binding motif in the TNF-alpha promoter . Positive_regulation TNF EGR1 9542779 498126 [TNF-alpha] *induces* the transcription factor , pro-inflammatory cytokines and cell proliferation in human skin fibroblasts and synovial lining cells . Positive_regulation TNF EGR2 23307302 2775431 and knock down of Egr-2 in primary mixed glial cultures ( MGC ) by siRNA showed that *promoted* the synthesis of [TNF-a] . Positive_regulation TNF EGR2 7585181 333656 and 5,000 cGy ( rad ) *resulted* in increased intratumoral [TNF-alpha] production and increased tumour control compared with treatment with Ad5 . Positive_regulation TNF EGR3 7585181 333657 and 5,000 cGy ( rad ) *resulted* in increased intratumoral [TNF-alpha] production and increased tumour control compared with treatment with Ad5 . Positive_regulation TNF EGR4 7585181 333658 and 5,000 cGy ( rad ) *resulted* in increased intratumoral [TNF-alpha] production and increased tumour control compared with treatment with Ad5 . Positive_regulation TNF EHMT1 11895929 920807 At 6 h of incubation , *induced* a significant rise in [tumor necrosis factor] alpha levels , which dropped progressively until 72 h of incubation . Positive_regulation TNF EHMT1 12874341 1115070 Activation of NF-kappa B and AP-1 by P. aeruginosa may be *involved* not only in [TNF-alpha] induction but also in many of the inflammatory responses triggered in the course of infection with P. aeruginosa . Positive_regulation TNF EHMT2 18809684 1987451 In contrast , knockdown disrupted promoter silencing and *restored* [TNFalpha] transcription in tolerant cells . Positive_regulation TNF EIF2AK2 10657661 664147 These results indicate that the is *required* for full activation of E-selectin expression by pIC and [TNF-alpha] in primary mouse aortic endothelial cells identifying activating transcription factor 2 as a new target for PKR dependent regulation and suggest a role for PKR in leukocyte adhesion . Positive_regulation TNF EIF2AK2 16924232 1692196 Overall , our results indicate that differentially *regulates* [TNF] signaling ; Positive_regulation TNF EIF2AK2 17690330 1842480 Moreover , inhibition of phosphorylation severely *impaired* [TNF-alpha] and IL-6 production by AM in response to LPS and Pam3CSK4 . Positive_regulation TNF EIF2AK2 19369349 2088998 PKR dependent activation of p38 and NF-kappaB was required for vaccinia virus induced INHBA expression , whereas induction of [TNF-alpha] *required* only dependent NF-kappaB activation . Positive_regulation TNF EIF2AK2 21699726 2451592 In these co-cultures , inhibition *prevented* Aß42 induced activation of I?B and NF-?B , strongly decreased production and release of [tumor necrosis factor] ( TNFa ) and interleukin (IL)-1ß , and limited apoptosis . Positive_regulation TNF EIF4E 2813400 121478 [Tumor necrosis factor] *induces* phosphorylation of a 28-kDa in human cervical carcinoma cells . Positive_regulation TNF EIF6 12888335 1117049 We hypothesized that with cardiopulmonary bypass ( `` on-pump '' ) activates human myocardial NF-kappaB and *increases* [TNF] in the heart . Positive_regulation TNF ELAVL1 12876290 1142498 Taken together , these data demonstrate that increased binding of to the TNFalpha 3'-UTR *contributes* to increased LPS stimulated [TNFalpha] expression in macrophages after chronic ethanol exposure . Positive_regulation TNF ELAVL1 16820934 1581607 While stabilizes TNF-alpha mRNA and *enhances* [TNF-alpha] production , TIA-1 acts as a post-transcriptional silencer , and suppresses the production of the TNF-alpha protein . Positive_regulation TNF ELAVL1 20161729 2215149 Berberine significantly *inhibited* HIV PI-induced [TNF-alpha] and IL-6 expression by modulating ER stress signaling pathways and subsequent ERK activation , in turn preventing the accumulation of the RNA binding protein in cytosol and inhibiting the binding of HuR to the 3'-UTRs of TNF-alpha and IL-6 in macrophages . Positive_regulation TNF ELF3 12746898 1088808 mRNA expression could be *induced* by IL-1beta and [TNFalpha] in cells such as synovial fibroblasts , chondrocytes , osteoblasts , and monocytes . Positive_regulation TNF ELL 10630309 659549 Further evidence of activation was that ET-18-OCH3 and strongly *induced* [tumor necrosis factor] alpha production by U-937 cells . Positive_regulation TNF ELL 16307187 1486479 Gradual nerve by limb lengthening *induces* production of [TNFalpha] in Schwann cells . Positive_regulation TNF ELL 22677561 2626197 *induced* production of Type-1 cytokines such as IL-12 and [TNF-a] from bone marrow derived dendritic cells ( BMDCs ) in TLR2- and TLR4 dependent manner and remarkably up-regulated the expression of MHC and co-stimulatory molecules . Positive_regulation TNF EPAS1 10483875 643910 Taken together , the data showed that and LPS had immunoregulatory properties with respect to LFA-1 expression on human PBMC and that these actions were *mediated* by monocytes and [TNF-alpha] . Positive_regulation TNF EPB41 20299954 2273029 Furthermore , expression in primary CD4 T cells *results* in increased production of interleukin (IL)-2 , IL-15 and [tumor necrosis factor (TNF)] , as well as IL-1RA ; Positive_regulation TNF EPB42 10850941 701500 Inhibition of activity with PD98059 *reduced* both AP-1 activity and [TNF] mRNA expression of LPS stimulated Mphi . Positive_regulation TNF EPB42 9698517 524938 Inhibition of with PD98059 or P38 with SB202190 significantly *reduced* [TNF] production by LPS stimulated RAW cells . Positive_regulation TNF EPHB2 10601128 574168 [Tumor necrosis factor-alpha (TNF-alpha)] alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 MAPK , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only . Positive_regulation TNF EPHB2 10712344 673997 [TNF-alpha] *induced* p38 MAP kinase and phosphorylation , but neither SB 203580 nor PD 98059 inhibited RANTES production . Positive_regulation TNF EPHB2 10924061 718164 Finally , inhibition of phosphorylation reduced , and NF-kappaB nuclear translocation *prevented* , [tumor necrosis factor-alpha] production . Positive_regulation TNF EPHB2 11076936 786247 We have studied the *role* of and p38 mitogen activated protein (MAP) kinase in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Positive_regulation TNF EPHB2 11453646 837074 Furthermore , [TNFalpha] *activation* of was abolished by a dominant negative Rac mutant , Rac17N , or by an activated Rac mutant , Rac12V . Positive_regulation TNF EPHB2 11675371 873198 Both and p38 can *regulate* [TNF-alpha] gene transcription induced by CpG DNA . Positive_regulation TNF EPHB2 11777978 899858 In contrast , SmO induction of the ERK pathway was increased compared with the SmT morphotype , and inhibition of *resulted* in decreased [TNF-alpha] synthesis and enhanced SmO growth . Positive_regulation TNF EPHB2 11920316 926081 pathway inhibitors significantly *reduced* [TNF] secretion when added at the same time as pneumococcal challenge , and inhibitors of both ERK and p38 pathways reduced TNF secretion when added to the macrophages 1 h before stimulation . Positive_regulation TNF EPHB2 11994488 939075 These findings were supported by functional data demonstrating that CQ and PD98059 interfered with TNF expression in several human and murine cell types while neither inhibitor blocked TNF production in murine RAW264.7 macrophages , a cell line that does not *require* signaling for [TNF] production . Positive_regulation TNF EPHB2 12055070 951579 HT-29 cells were treated with [tumor necrosis factor-alpha (TNF-alpha)] in the *presence* or absence of and p38 pathway inhibitors . Positive_regulation TNF EPHB2 12438325 1016559 The activation of protein tyrosine kinases (PTK) and the serine/threonine kinases p38 MAPK and was apparently *required* for MTSA-10 induction of [TNF-alpha] and NO release , as revealed by specific kinase inhibitors . Positive_regulation TNF EPHB2 12673950 1076641 and JNK are also *involved* in ATP induced [TNF] transcription , while p38 regulates the transport of TNF mRNA from the nucleus to the cytosol . Positive_regulation TNF EPHB2 12797541 1098686 Using highly specific inhibitors of p38 ( SB203580 ) and of MAPK kinase-1 ( U0126 and PD98059 ) , we found that both p38 and were *essential* for M. tuberculosis H37Rv induced [TNF-alpha] production , whereas activation of the p38 pathway , but not that of ERK , was essential for M. tuberculosis H37Rv induced IL-10 production . Positive_regulation TNF EPHB2 12871593 1114176 Interestingly , PD98059 , an inhibitor of , *inhibited* p40 induced expression of [TNF-alpha] through the inhibition of C/EBPbeta , but not that of NF-kappaB , whereas SB203580 , an inhibitor of p38 MAPK , inhibited p40 induced expression of TNF-alpha through the inhibition of both NF-kappaB and C/EBPbeta . Positive_regulation TNF EPHB2 15792794 1386863 *dependent* induction of [TNFalpha] expression by the environmental contaminant benzo ( a ) pyrene in primary human macrophages . Positive_regulation TNF EPHB2 16160917 1456079 The analysis of cytokine production using specific inhibitors of the MAPK pathway revealed that both p38 and activation are *essential* for PPD induced [TNF-alpha] production , whereas p38 , but not ERK , activation is essential for IL-10 secretion . Positive_regulation TNF EPHB2 16297883 1502766 Dioscorin also stimulated multiple signaling molecules ( NF-kappaB , , JNK , and p38 ) and *induced* the expression of cytokines ( [TNF-alpha] , IL-1beta , and IL-6 ) in murine RAW 264.7 macrophages . Positive_regulation TNF EPHB2 16418769 1495060 [TNFalpha] *induced* p38 and activation , whereas oridonin triggered only ERK activation . Positive_regulation TNF EPHB2 17056543 1636589 The MAPK is *required* for LPS induced [TNF] production by macrophages . Positive_regulation TNF EPHB2 17567906 1763215 Functionally , transiently overexpressed Zfra sequestered NF-kappaB ( p65 ) , WOX1 , p53 and ( extracellular signal activated kinase ) in the cytoplasm , and [TNF] or UV light could not effectively *induce* nuclear translocation of these proteins . Positive_regulation TNF EPHB2 17607712 1798169 Although [TNF] *induced* the activation of p38 MAPK , JNK , and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation TNF EPHB2 17913704 1830213 Together with cPLA(2) redistribution and AA release , [TNFalpha] *induced* a time dependent phosphorylation of , MSK1 , PKCzeta , CaMKII , and phospholamban on the threonine 17 residue . Positive_regulation TNF EPHB2 17934341 1813477 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and , but not c-Src , JNK , nor p38 MAPK . Positive_regulation TNF EPHB2 18622138 1984352 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 MAPK and activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Positive_regulation TNF EPHB2 19201817 2061382 Activation of GPR54 resulted in the *dependent* expression of [tumor necrosis factor-alpha] and FasL in a lymphoid cell line , the latter being the main trigger of apoptosis . Positive_regulation TNF EPHB2 19299480 2106074 In the present study , we demonstrate that CGRP is involved in morphine tolerance by differentially regulating the *dependent* up-regulation of IL-1beta , [TNF-alpha] , and microsomal prostaglandin E synthase-1 ( mPGES-1 ) in astrocytes and p38 dependent up-regulation of IL-6 in microglia in the rat spinal cord . Positive_regulation TNF EPHB2 19561104 2104173 We determined that acute alcohol decreased but chronic alcohol increased activation of in monocytes and ERK inhibitor , PD98059 , *prevented* the chronic alcohol induced increase in [TNF-alpha] . Positive_regulation TNF EPHB2 20083499 2380888 For the first time , we show that , in fish macrophages , [TNF-a] is processed by TACE-like activity and this cleavage is *dependent* upon the activation of , p38MAPK and JNK signaling pathways by LPS . Positive_regulation TNF EPHB2 21256190 2398036 Hypertonicity enhanced [TNF-a] release from activated human monocytic THP-1 cells *requires* activation . Positive_regulation TNF EPHB2 21256190 2398038 Hypertonicity enhanced [TNF-a] protein synthesis from LPS- or PMA activated THP-1 cells *requires* activation and may proceed without TACE . Positive_regulation TNF EPHB2 21354239 2431662 Pharmacological studies revealed that the integrity of lipid raft and the activation of Src , Ras , Raf , , and NF-?B all *contributed* to JEV induced [TNF-a] and IL-1ß expression . Positive_regulation TNF EPHB2 22733995 2639205 The Nfkb1 ( SSAA ) mutation prevented the agonist induced release of TPL-2 from its inhibitor p105 , which blocked *activation* of by lipopolysaccharide (LPS) , [tumor necrosis factor (TNF)] , CpG , tripalmitoyl-Cys-Ser-Lys ( Pam ( 3 ) CSK ) , poly ( I · C ) , flagellin , and R848 . Positive_regulation TNF EPHB2 23619565 2804766 Further studies revealed that PL suppressed the production of [tumor necrosis factor-a (TNF-a)] or Interleukin (IL)-6 and *activation* of nuclear factor-?B ( NF-?B ) or 1/2 by LPS . Positive_regulation TNF EPHB2 23734186 2796922 Bla g 2 can stimulate up-regulation of inflammatory cytokines including [TNF-alpha] and IL-6 and *activation* of nuclear factor kappa B ( NF-kB/p65 ) , p38 mitogen activated protein kinase ( p38 ) , , and JNK in cultured fibrocytes . Positive_regulation TNF EPHB2 23734186 2796949 This increased secretion of [TNF-alpha] and IL-6 and *activation* of NF-kB , , and JNK was significantly inhibited by the addition of either mannan or mannose . Positive_regulation TNF EPHB2 24262867 2898242 Further studies revealed that PT suppressed the production of [tumor necrosis factor-a (TNF-a)] or Interleukin (IL)-6 and *activation* of nuclear factor-?B ( NF-?B ) or 1/2 by LPS . Positive_regulation TNF EPS15 16332508 1503694 *induced* IL-12 , IFN-gamma , IFN-alpha , [TNF-alpha] and IL-18 , but not IL-4 . Positive_regulation TNF EPS15 20811959 2388965 Tumor necrosis factor alpha ( TNF-a ) , interferon-a ( IFN-? ) , and interleukin-2 (IL-2) mRNA levels in splenocytes and thymocytes were increased after EPS treatment for 2 , 4 , 8 , or 20 h . also significantly elevated splenic TNF-a and IFN-? protein expressions at 100 µg/ml and *increased* thymic [TNF-a] and IFN-? protein levels at 50 and 100 µg/ml . Positive_regulation TNF EPS15 21950581 2512526 We also examined the relationship between [TNF-a] production and *activation* of mitogen activated protein kinases ( MAPKs ) by and LPS . Positive_regulation TNF EPS8 16332508 1503695 *induced* IL-12 , IFN-gamma , IFN-alpha , [TNF-alpha] and IL-18 , but not IL-4 . Positive_regulation TNF EPS8 20811959 2388966 Tumor necrosis factor alpha ( TNF-a ) , interferon-a ( IFN-? ) , and interleukin-2 (IL-2) mRNA levels in splenocytes and thymocytes were increased after EPS treatment for 2 , 4 , 8 , or 20 h . also significantly elevated splenic TNF-a and IFN-? protein expressions at 100 µg/ml and *increased* thymic [TNF-a] and IFN-? protein levels at 50 and 100 µg/ml . Positive_regulation TNF EPS8 21950581 2512527 We also examined the relationship between [TNF-a] production and *activation* of mitogen activated protein kinases ( MAPKs ) by and LPS . Positive_regulation TNF EPX 12393629 1035729 also could *induce* [TNF-alpha] expression in BAF3 and DA3 myeloid cells ectopically expressing EPOR . Positive_regulation TNF EPX 15242770 1270751 BAF3 cells expressing a mutant EPOR with no cytoplasmic tyrosine residues were capable of triggering *dependent* [TNF-alpha] synthesis and secretion , indicating that tyrosine docking sites in the EPOR were not required for EPO dependent TNF-alpha secretion . Positive_regulation TNF EPX 18948032 2078969 Compared with placebo , at day 3 after CPB *augmented* the [TNF-alpha] response ( p < 0.05 ) and at 2 hours after CPB increased NT-proBNP ( p < 0.05 ) . Positive_regulation TNF EPX 18948032 2078970 In contrast , may *augment* the [TNF-alpha] and NT-proBNP response . Positive_regulation TNF EPX 19079544 2003220 *increased* [TNF-alpha] levels and shifted the Bcl-x ( L ) to Bax ratio towards the pro-apoptotic Bax resulting in significantly increased hepatocellular apoptosis . Positive_regulation TNF EPX 7774640 308859 Human *enhances* [tumor necrosis factor] and hydrogen peroxide release by human monocyte derived macrophages . Positive_regulation TNF ERAL1 10203355 606166 Cells were stimulated with [TNF-alpha] or LPS plus IFN-gamma in the *presence* of NF-kappaB inhibitors , , or the more specific JAK2 inhibitor AG490 . Positive_regulation TNF ERBB2 11960379 932344 *potentiated* [tumor necrosis factor alpha (TNFalpha)-inducible] NF-kappaB activation whereas c-Myc potentiated 12-o-tetracecanyolphorbol-13-acetate ( TPA ) -induced NF-kappaB activation . Positive_regulation TNF ERBB2 19760502 2264277 We found that [TNFalpha] *induces* phosphorylation in mouse breast cancer C4HD cells and in the human breast cancer cell lines SK-BR-3 and BT-474 . Positive_regulation TNF ERBB2 22922291 2710274 It was uncovered that was a new substrate for caspase-8 and that [tumor necrosis factor a (TNF-a)] stimulation *resulted* in a caspase-8 dependent Her-2 cleavage in MCF-7 breast adenocarcinoma cells defective for nuclear factor ?B ( NF?B ) activation . Positive_regulation TNF ERVK-6 10615006 575781 On the other hand , the 45 kDa did not *stimulate* the production of PGE2 , IL-1beta , and [TNF-alpha] from the macrophages . Positive_regulation TNF ERVK-6 9688944 522686 Because [TNF-alpha] can *induce* expression in endothelial cells , we determined whether proteinases cause both the alteration of the Fn matrix and the permeability increase as is often speculated . Positive_regulation TNF ESAT 22192908 2549554 Meanwhile , several studies showed that CFP10 and could inhibit and/or *promote* the production of [tumor necrosis factor a (TNF-a)] from macrophages . Positive_regulation TNF ETS1 11229456 788633 Both IL-1 and [TNFalpha] *induced* pronounced up-regulation of in synovial fibroblasts . Positive_regulation TNF ETS1 11689211 876131 [TNFalpha] *induces* expression of transcription factors c-fos , Egr-1 , and in vascular lesions through extracellular signal regulated kinases 1/2 . Positive_regulation TNF ETS1 11689211 876140 In cultured RAW 264.7 mouse macrophages , [TNFalpha] similarly *induced* the expression of , Egr-1 , and c-fos . Positive_regulation TNF ETS1 24189042 2868406 [TNF] *induced* mRNA expression of and ß6-integrin in HT29 IEC and in CLPF from fistulizing CD patients . Positive_regulation TNF ETS1 7896795 299863 These data suggest an essential *role* of for the activation of [TNF] gene transcription . Positive_regulation TNF ETS2 15240733 1270484 phosphorylation was *required* for persistent activation of [TNF-alpha] following LPS stimulation of bone marrow derived macrophages . Positive_regulation TNF ETS2 7896795 299864 These data suggest an essential *role* of for the activation of [TNF] gene transcription . Positive_regulation TNF F2R 12506061 1038278 HCE-T expression of cytokines ( IL-6 , IL-8 , and [TNFalpha] ) in *response* to activation of and -2 was measured by quantitative RT-PCR and ELISA . Positive_regulation TNF F2RL1 12506061 1038279 HCE-T expression of cytokines ( IL-6 , IL-8 , and [TNFalpha] ) in *response* to activation of was measured by quantitative RT-PCR and ELISA . Positive_regulation TNF F2RL1 22613992 2603852 Inhibition of activation *reduced* tryptase induced [TNF-alpha] , IL-6 and ROS production , and mitochondrial membrane potential loss in microglia . Positive_regulation TNF F2RL3 17142351 1701007 [TNF-alpha] and LPS *induced* mRNA expression ( RT-PCR ) at 6 h and 24 h , respectively . Positive_regulation TNF F3 8420984 210660 is not normally expressed in cells that contact blood , such as endothelial cells and monocytes , but can be *induced* in these cells by [tumor necrosis factor] or tumor promoting phorbol esters . Positive_regulation TNF F3 8706889 373512 expression on the surface of endothelial cells can be *induced* by [tumor necrosis factor (TNF)] and vascular endothelial growth factor ( VEGF ) in a synergistic manner . Positive_regulation TNF FADD 16924232 1692184 [TNF] *induced* the expression of NF-kappaB regulated gene products cyclin D1 , c-Myc , matrix metalloproteinase-9 , survivin , X-linked inhibitor-of-apoptosis protein ( IAP ) , IAP1 , Bcl-x ( L ) , A1/Bfl-1 and IL-1beta converting enzyme-inhibitory protein in wild-type MEF but not in PKR-/- cells . Positive_regulation TNF FAH 7558438 323485 Vinblastine , unlike , , *causes* no increase in plasma [TNF alpha] levels in mice bearing the CaNT tumour , suggesting 2 distinct mechanisms of anti-vascular activity for these structurally diverse agents . Positive_regulation TNF FAH 8950158 400734 These effects in skin occurred in the absence of any blood perfusion changes , but appeared to be associated with *induced* [TNF-alpha] production . Positive_regulation TNF FAH 9413946 471640 *caused* no increase in [TNF] protein , while LPS induced TNF to approximately 20-fold higher levels than did DMXAA . Positive_regulation TNF FARP2 19276662 2079765 Like-wise , *induced* the expression of IAP1 , IAP2 , XIAP Survivin , MnSOD , [TNFalpha] , pAKT and IL-1alpha . Positive_regulation TNF FAS 10082135 597608 Apoptosis *induced* by [TNF-alpha] alone or with ligation also occurred more frequently in null mouse HPC . Positive_regulation TNF FAS 10895367 711568 Our findings suggest that IFN-gamma or [TNF-alpha] secreted by infiltrating lymphocytes *induces* ductal expression and ductal apoptosis in sialoadenitis associated with SS . Positive_regulation TNF FAS 11676830 873540 Whereas interferon-gamma and TNF-alpha either alone or in combination did not induce apoptosis in keratinocytes , after infection with the retrovirus to block NF-kappaB activation they became susceptible to [TNF-alpha] but not *induced* apoptosis . Positive_regulation TNF FAS 12032671 948104 Soluble Fas gene therapy protects against Fas mediated apoptosis of hepatocytes but not the lethal effects of *induced* [TNF-alpha] production by Kupffer cells . Positive_regulation TNF FAS 12119470 964935 mRNA expression ( ratio of Fas/L-19 ) *increased* in the [TNF-alpha] 5 , 30 ng/ml and LPS treated group ( p < 0.01 , p < 0.01 , p = 0.02 ) , but there was no difference between the low- and high-dose TNF-alpha groups . Positive_regulation TNF FAS 12391181 1007225 Apoptosis of the adherent cells was markedly inhibited by anti-Fas ligand (FasL) Ab. RT-PCR and FACS analyses revealed that [TNF-alpha] up-regulated Fas transcription to lead to Fas expression on the surfaces of the adherent cells , whereas IL-12 could not *induce* on the cells . Positive_regulation TNF FAS 12660450 1074178 Synergism of *mediated* apoptosis and [tumor necrosis factor] on adriamycin cytotoxicity to transitional cell carcinoma . Positive_regulation TNF FAS 12660450 1074179 The synergism efficacy of *mediated* apoptosis and [TNF-alpha] on adriamycin cytotoxicity of TCC cells was analyzed . Positive_regulation TNF FAS 14597220 1160402 Fas ligand and [TNF-alpha] were also *detected* among pancreas infiltrating cells , whereas was rarely expressed in the pancreatic acinar cells . Positive_regulation TNF FAS 14729358 1198387 In the primary cultured cells , [TNFalpha] *induced* an important upregulation of ICAM-1 , and CD40 whereas CD44 and CD63 were significantly decreased . Positive_regulation TNF FAS 14738570 1242693 Cultured human coronary artery endothelial cells ( HCAEC ) were exposed to the monoclonal *activating* antibody CH-11 , to purified recombinant human Fas ligand , to the Fas neutralizing antibody ZB4 , or to purified recombinant human [TNF-alpha] . Positive_regulation TNF FAS 15644494 1381418 This investigation further demonstrates that HR3 cells also exhibited cross-resistance to death ligands [ *inducing* antibody and [tumor necrosis factor (TNF)-alpha] ] . Positive_regulation TNF FAS 16785543 1577114 We additionally determined that IL-1beta and [TNF-alpha] secretion by beta-glucan stimulated DCs was partially *regulated* by . Positive_regulation TNF FAS 19595469 2117918 AS101 inhibited [TNFalpha] or *induced* apoptotic processes in hepatocytes in vitro . Positive_regulation TNF FAS 20809180 2388943 Saturated were potent *inducers* of [TNF-a] expression and secretion under basal and inflammatory conditions ( in the presence of LPS ) . Positive_regulation TNF FAS 23604035 2810401 We first observed that was *induced* by [TNF-a] in the HL60 cell line . Positive_regulation TNF FAS 7538467 301319 Whether , like [TNF] receptor , also *mediates* proliferation of normal human diploid fibroblasts ( HDF ) , is not known . Positive_regulation TNF FAS 7542501 314113 However , IFN-gamma and/or [TNF-alpha] *induced* the expression of both the mRNA of Fas and itself in a dose dependent fashion on the surface of CD34+ cells after 48 hours of serum-free culture . Positive_regulation TNF FAS 7542501 314124 These observations indicate that IFN-gamma and/or [TNF-alpha] , well known as negative hematopoietic regulators , *induce* functional on hematopoietic progenitor cells . Positive_regulation TNF FAS 8648118 363667 As and TNF receptor are similar , and [TNF/TNF] receptor binding *induces* oxygen radicals , the involvement of oxidant and antioxidant systems in CD95 mediated apoptosis has been examined . Positive_regulation TNF FAS 8741668 377112 However , interferon-gamma(IFN-gamma) and/or [tumor necrosis factor-alpha (TNF-alpha)] *induced* the expression of after 48 hours of serum-free culture . Positive_regulation TNF FAS 9028968 413564 Characterization of T-cell clones derived from peripheral blood lymphocytes of a patient with transfusion associated graft-versus-host disease : *mediated* killing by CD4+ and CD8+ cytotoxic T-cell clones and [tumor necrosis factor] beta production by CD4+ T-cell clones . Positive_regulation TNF FAS 9049961 406019 However , interferon-gamma (IFN-gamma) and/or [tumor necrosis factor-alpha (TNF-alpha)] *induced* dose dependent expression of both Fas mRNA and protein on the surface of CD34+ cells after 48 hours of serum-free culture . Positive_regulation TNF FAS 9384699 408094 was *induced* by [TNF] in 6/12 myeloid leukemia cell lines , and by IFN in 9/12 cell lines . Positive_regulation TNF FAS 9530222 496738 [TNF] *activation* of TNF receptor 1 or may induce cardiac myocyte apoptosis . Positive_regulation TNF FASLG 10544178 563984 In contrast , [TNF] did not *induce* the expression of on LEC-1 . Positive_regulation TNF FASLG 11408858 826127 Neither lipopolysaccharide nor [tumor necrosis factor] *induced* expression in human fetal membranes . Positive_regulation TNF FASLG 11870083 918406 Cells were exposed to IFN and/or TNF for 24 h and were further treated with IFN and/or [TNF] in the *presence* or absence of ( 100 ng/ml ) for 24 h. Treatments of the cells with IFN alone and in combination with TNF resulted in killing of 30 % and 50 % of the cells ( P < 0.05 ) , respectively , whereas TNF alone did not have a cytotoxic effect on the cells . Positive_regulation TNF FASLG 12119470 964936 protein expression did not *increase* in the low-dose [TNF-alpha] treated group , but it increased significantly in the high-dose TNF-alpha treated group ( p < 0.01 ) , IL-1beta- and LPS treated groups ( p < 0.01 , p = 0.01 , p < 0.01 , p = 0.02 ) . Positive_regulation TNF FASLG 12391181 1007227 In contrast , IL-12 induced FasL transcription to lead to FasL expression on the surfaces of nonadherent bone marrow cells , whereas [TNF-alpha] could not *induce* on the cells . Positive_regulation TNF FASLG 16025512 1435665 These in vitro studies demonstrated that [TNF-alpha] induces CD40 expression in hepatocytes and that subsequent activation of CD40 results in hepatocyte apoptosis *mediated* at least in part by enhanced hepatocyte expression of . Positive_regulation TNF FASLG 16785543 1577115 We additionally determined that IL-1beta and [TNF-alpha] secretion by beta-glucan stimulated DCs was partially *regulated* by . Positive_regulation TNF FASLG 16858424 1625422 In HaCaT cells and in reconstructed human epidermis ( RHE ) , *triggered* a NF-kappaB dependent mRNA accumulation of inflammatory cytokines ( [tumor necrosis factor-alpha] , IL-6 , and IL-1beta ) , chemokines ( CCL2/MCP-1 , CXCL1/GROalpha , CXCL3/GROgamma , and CXCL8/IL-8 ) , and the adhesion molecule ICAM-1 . Positive_regulation TNF FASLG 17016642 1629973 We found that mAb treatment activates Kupffer cells to produce inflammatory cytokines such as [TNF-alpha] and IL-12 , and *induces* the expression of on Kupffer and NKT cells . Positive_regulation TNF FASLG 22492973 2613135 In late CL cells , [TNF] and TNF+IFNG+FASL reduced VEGFR2 mRNA , but *increased* TSP1 and CD36 mRNA . Positive_regulation TNF FASLG 9164947 432146 We also show that the killing of Ag-presenting , sensitive cells is mediated by and TNF-alpha as well as perforin , although the latter plays a major role in the killing at a low E : T ratio , and that the killing of sensitive bystander cells is primarily *mediated* by Fas ligand and [TNF-alpha] on CTLs expressed upon specific Ag stimulation , which may be relevant to the bystander lysis by HCV-specific CTLs of uninfected hepatocytes , in which Fas expression is up-regulated . Positive_regulation TNF FASLG 9378984 465717 The in vivo administration of anti-IL-18 just before an LPS challenge suppressed not only the induction of IFN-gamma and the late [TNF-alpha] elevation , but also the *induction* , resulting in the total prevention of liver injury , whereas such an anti-IL-12 treatment did not . Positive_regulation TNF FCER1G 10438475 634831 Expression of a mutated ( T60A ) , in either FcepsilonRIgamma-deficient or gamma-null mast cells , *resulted* in a delay of FcepsilonRI endocytosis , inhibition of [TNF-alpha] mRNA production , and inhibition of degranulation but did not affect FcepsilonRI induced cell adhesion . Positive_regulation TNF FCER2 10212304 607914 The activation of also *led* to an upregulation of [TNF-alpha] production , which was dependent on NO release . Positive_regulation TNF FCER2 12635574 1068506 Our results indicated that [TNF-alpha] production was *induced* by D. farinae in PBMCs of patients with atopic asthma by the activation of NF-kappa B via . Positive_regulation TNF FCER2 1334783 205922 This expression *leads* to the IgE dependent production of the potent pro-inflammatory cytokines IL-1 beta and [TNF-alpha] . Positive_regulation TNF FCER2 14700442 1180520 Stimulating the receptor with immune complexes significantly *increased* [TNF-alpha] production by THP-1 cells stimulated with IFN-gamma , IL-4 , IL-13 , or a combination of these . Positive_regulation TNF FCER2 1707698 155072 However , G-CSF and [TNF-alpha] did not *induce* the expression of and EO-1 antigen . Positive_regulation TNF FCER2 19805542 2159644 activation also *induced* [tumor necrosis factor alpha (TNF-alpha)] production from MDM . Positive_regulation TNF FCER2 2142456 137520 Of several cytokines tested [interleukin (IL) 1 to IL 6 , interferon-gamma (IFN-gamma) , [tumor necrosis factor-alpha] ] only IL 4 and IFN-gamma significantly modified allergen *induced* expression on T cells . Positive_regulation TNF FCER2 22767513 2696985 We found that downregulation of *attenuated* AIMP1 induced [TNF-a] secretion and AIMP1 binding to THP-1 and PBMCs . Positive_regulation TNF FCER2 22767513 2696989 We also observed that in THP-1 and PBMCs , AIMP1 induced [TNF-a] secretion , *mediated* by , involved activation of ERK1/2 . Positive_regulation TNF FCER2 7522713 272116 In the present study , we showed that the ligation of by IgE/anti-IgE immune complexes or specific monoclonal antibody , *induces* a dose dependent release of interleukin-6 and [tumor necrosis factor-alpha] from EK . Positive_regulation TNF FCER2 7949182 277328 ligation also *induced* the production of [TNF alpha] by U937 cells . Positive_regulation TNF FCER2 8182161 256555 In the present study , we showed that the ligation of by IgE/anti-IgE immune complexes or specific monoclonal antibody *induces* a dose dependent release of interleukin 6 and [tumor necrosis factor-alpha] from EK . Positive_regulation TNF FCER2 8647222 366322 In the presence of Rp-cAMP , the *induced* production of IL-10 and of the pro-inflammatory cytokine [tumor necrosis factor-alpha (TNF-alpha)] was totally abrogated , whereas , in the presence of L-NMMA , IL-10 production was enhanced and TNF-alpha production was suppressed . Positive_regulation TNF FCER2 8900533 393540 p24 induction by IgE-IC was then shown to be due to *mediated* stimulation of cAMP , NO , and [tumor necrosis factor alpha (TNF alpha)] generation . Positive_regulation TNF FCER2 9550368 477752 Treatment of HK with anti-IL-10 mAb potentiated their *mediated* [TNF-alpha] synthesis . Positive_regulation TNF FCGR1A 12731072 1086837 Both and Fc epsilon RI aggregation also activated the MAP kinases ERK 1/2 , JNK and p38 and this was *necessary* for [TNF-alpha] synthesis , but not degranulation for both receptors . Positive_regulation TNF FCGR1A 2137489 127120 Cross linking of both and Fc gamma RII *induces* secretion of [tumor necrosis factor] by human monocytes , requiring high affinity Fc-Fc gamma R interactions . Positive_regulation TNF FCGR1A 2254998 146330 IgG stimulation of patients ' MO through not only *stimulated* [TNF alpha] , IL-6 , and PGE2 levels , but also greatly augmented the levels of these monokines produced after subsequent bacterial challenge . Positive_regulation TNF FCGR1A 23299081 2737870 Both IFN-a and IFN-ß strongly reduced the production of IL-12p40 , IL-1ß and [TNF] and the IFN-? *induced* CD54 and expression . Positive_regulation TNF FCGR3A 10925255 718707 Target cell induced IFN-gamma and *induced* [TNF-alpha] mRNA accumulation was similarly affected under the same conditions . Positive_regulation TNF FCGR3A 11390467 822531 Indeed , ligation of on Vgamma9Vdelta2 T cells *leads* to [TNF-alpha] production . Positive_regulation TNF FCGR3A 19180470 2033007 Moreover , the [TNF-alpha] production *induced* by cross linking was reduced in monocytes after treatment with siRNA against NF-kappaB , implying that this transcription factor functioned in TNF-alpha production . Positive_regulation TNF FCGR3A 9862693 556043 We have reported that ERK2 phosphorylation and activation follows engagement of the low affinity receptor for the Fc portion of IgG ( CD16 ) on NK cells , and is necessary for *induced* [TNF-alpha] mRNA expression . Positive_regulation TNF FCGR3B 10415049 631178 SNAP also suppressed , and L-NMA enhanced , expression of [TNF-alpha] , reported to be involved in activation induced NK cell death , in *response* to cross linking . Positive_regulation TNF FCGR3B 15146415 1247785 antibody stimulation markedly *enhanced* the LTA induced [TNFalpha] response . Positive_regulation TNF FES 16874150 1593511 also *causes* a significant reduction of TNF-alpha ( -11.5+/-8.9 % ) , sICAM-1 ( -13.1+/-9.8 % ) , and sVCAM-1 ( -10.6+/-6.6 % ) , as well as a respective increase in the ratio [IL-10/TNF-alpha] ( 37.1+/-29.4 % ) . Positive_regulation TNF FGA 21439977 2421809 and FDP *promote* more protein expressions of IL-6 and [TNF-a] compared to iNOS , suggesting that fibrinogen and FDP produce a pro-inflammatory effect on VSMCs mainly by IL-6 and TNF-a . Positive_regulation TNF FGB 11922467 926433 However , depending on the presence and type of agonist , *mediated* either a markedly increased ( LPS ) or equivalent ( particles and unstimulated ) IL-1alpha and [TNFalpha] release . Positive_regulation TNF FGF1 14729638 1198586 Consistent with these data , rhES inhibited VCAM-1 dependent B16M cell adhesion to primary cultured HSE receiving B16M conditioned medium , and it abolished the HSE cell production of [TNF-alpha] and IL-18 *induced* by tumor derived vascular ( VEGF ) . Positive_regulation TNF FGF1 8384689 214801 We also found that significantly *enhanced* [TNF alpha] receptor expression . Positive_regulation TNF FGF1 8384689 214823 The mediated *increase* in [TNF alpha] receptor expression and TNF alpha mediated PGE2 production could be abolished by FGF mAbs , indicating a specific FGF effect . Positive_regulation TNF FGF10 8384689 214802 We also found that significantly *enhanced* [TNF alpha] receptor expression . Positive_regulation TNF FGF10 8384689 214824 The mediated *increase* in [TNF alpha] receptor expression and TNF alpha mediated PGE2 production could be abolished by FGF mAbs , indicating a specific FGF effect . Positive_regulation TNF FGF11 8384689 214803 We also found that significantly *enhanced* [TNF alpha] receptor expression . Positive_regulation TNF FGF11 8384689 214825 The mediated *increase* in [TNF alpha] receptor expression and TNF alpha mediated PGE2 production could be abolished by FGF mAbs , indicating a specific FGF effect . Positive_regulation TNF FGF12 8384689 214804 We also found that significantly *enhanced* [TNF alpha] receptor expression . Positive_regulation TNF FGF12 8384689 214826 The mediated *increase* in [TNF alpha] receptor expression and TNF alpha mediated PGE2 production could be abolished by FGF mAbs , indicating a specific FGF effect . Positive_regulation TNF FGF13 8384689 214805 We also found that significantly *enhanced* [TNF alpha] receptor expression . Positive_regulation TNF FGF13 8384689 214827 The mediated *increase* in [TNF alpha] receptor expression and TNF alpha mediated PGE2 production could be abolished by FGF mAbs , indicating a specific FGF effect . Positive_regulation TNF FGF14 8384689 214806 We also found that significantly *enhanced* [TNF alpha] receptor expression . Positive_regulation TNF FGF14 8384689 214828 The mediated *increase* in [TNF alpha] receptor expression and TNF alpha mediated PGE2 production could be abolished by FGF mAbs , indicating a specific FGF effect . Positive_regulation TNF FGF16 8384689 214807 We also found that significantly *enhanced* [TNF alpha] receptor expression . Positive_regulation TNF FGF16 8384689 214829 The mediated *increase* in [TNF alpha] receptor expression and TNF alpha mediated PGE2 production could be abolished by FGF mAbs , indicating a specific FGF effect . Positive_regulation TNF FGF17 8384689 214808 We also found that significantly *enhanced* [TNF alpha] receptor expression . Positive_regulation TNF FGF17 8384689 214830 The mediated *increase* in [TNF alpha] receptor expression and TNF alpha mediated PGE2 production could be abolished by FGF mAbs , indicating a specific FGF effect . Positive_regulation TNF FGF18 8384689 214809 We also found that significantly *enhanced* [TNF alpha] receptor expression . Positive_regulation TNF FGF18 8384689 214831 The mediated *increase* in [TNF alpha] receptor expression and TNF alpha mediated PGE2 production could be abolished by FGF mAbs , indicating a specific FGF effect . Positive_regulation TNF FGF19 8384689 214810 We also found that significantly *enhanced* [TNF alpha] receptor expression . Positive_regulation TNF FGF19 8384689 214832 The mediated *increase* in [TNF alpha] receptor expression and TNF alpha mediated PGE2 production could be abolished by FGF mAbs , indicating a specific FGF effect . Positive_regulation TNF FGF2 10625622 658578 NF-kappaB was activated after the stimulation of TRAP , bFGF , and TNF-alpha in electrophoretic mobility shift assay , and E5510 suppressed the NF-kappaB activation *induced* by TRAP and but not the activation by [TNF-alpha] . Positive_regulation TNF FGF2 10892857 711308 Both IL-1beta and [TNF-alpha] *induced* a significant decrease in uPA expression in PBF , whereas induced a slight increase in both HJF and PBF . Positive_regulation TNF FGF2 15943814 1415888 Endotoxin ( LPS ) , interferon gamma (IFNgamma) , [tumour-necrosis factor (TNF)] and TGF-beta did not *induce* the S100A8 gene in murine fibroblasts whereas induced mRNA maximally after 12 h . Positive_regulation TNF FGF2 7744816 306289 [TNF alpha] and *induction* of ROS production is mediated through flavonoid containing enzymes such as NADPH oxidase . Positive_regulation TNF FGF2 8384689 214811 We also found that significantly *enhanced* [TNF alpha] receptor expression . Positive_regulation TNF FGF2 8384689 214833 The mediated *increase* in [TNF alpha] receptor expression and TNF alpha mediated PGE2 production could be abolished by FGF mAbs , indicating a specific FGF effect . Positive_regulation TNF FGF2 8601593 351899 and VEGF165 enhanced of the u-PAR by 72 and 46 % , but [TNFalpha] itself also *increased* u-PAR in hMVEC by 30 % . Positive_regulation TNF FGF2 8739304 374240 Immunohistochemical localization of , platelet *derived* growth factor , transforming growth factor-beta and [tumor necrosis factor-alpha] in the pterygium . Positive_regulation TNF FGF2 9456251 484488 OSM , IL-1 and [TNF-alpha] *induced* the transcriptional activation of a promoter reporter gene in parallel with the activation of an AP-1 reporter . Positive_regulation TNF FGF20 8384689 214812 We also found that significantly *enhanced* [TNF alpha] receptor expression . Positive_regulation TNF FGF20 8384689 214834 The mediated *increase* in [TNF alpha] receptor expression and TNF alpha mediated PGE2 production could be abolished by FGF mAbs , indicating a specific FGF effect . Positive_regulation TNF FGF21 8384689 214813 We also found that significantly *enhanced* [TNF alpha] receptor expression . Positive_regulation TNF FGF21 8384689 214835 The mediated *increase* in [TNF alpha] receptor expression and TNF alpha mediated PGE2 production could be abolished by FGF mAbs , indicating a specific FGF effect . Positive_regulation TNF FGF22 8384689 214814 We also found that significantly *enhanced* [TNF alpha] receptor expression . Positive_regulation TNF FGF22 8384689 214836 The mediated *increase* in [TNF alpha] receptor expression and TNF alpha mediated PGE2 production could be abolished by FGF mAbs , indicating a specific FGF effect . Positive_regulation TNF FGF23 8384689 214815 We also found that significantly *enhanced* [TNF alpha] receptor expression . Positive_regulation TNF FGF23 8384689 214837 The mediated *increase* in [TNF alpha] receptor expression and TNF alpha mediated PGE2 production could be abolished by FGF mAbs , indicating a specific FGF effect . Positive_regulation TNF FGF3 8384689 214816 We also found that significantly *enhanced* [TNF alpha] receptor expression . Positive_regulation TNF FGF3 8384689 214838 The mediated *increase* in [TNF alpha] receptor expression and TNF alpha mediated PGE2 production could be abolished by FGF mAbs , indicating a specific FGF effect . Positive_regulation TNF FGF4 8384689 214817 We also found that significantly *enhanced* [TNF alpha] receptor expression . Positive_regulation TNF FGF4 8384689 214839 The mediated *increase* in [TNF alpha] receptor expression and TNF alpha mediated PGE2 production could be abolished by FGF mAbs , indicating a specific FGF effect . Positive_regulation TNF FGF5 8384689 214818 We also found that significantly *enhanced* [TNF alpha] receptor expression . Positive_regulation TNF FGF5 8384689 214840 The mediated *increase* in [TNF alpha] receptor expression and TNF alpha mediated PGE2 production could be abolished by FGF mAbs , indicating a specific FGF effect . Positive_regulation TNF FGF6 8384689 214819 We also found that significantly *enhanced* [TNF alpha] receptor expression . Positive_regulation TNF FGF6 8384689 214841 The mediated *increase* in [TNF alpha] receptor expression and TNF alpha mediated PGE2 production could be abolished by FGF mAbs , indicating a specific FGF effect . Positive_regulation TNF FGF7 8384689 214820 We also found that significantly *enhanced* [TNF alpha] receptor expression . Positive_regulation TNF FGF7 8384689 214842 The mediated *increase* in [TNF alpha] receptor expression and TNF alpha mediated PGE2 production could be abolished by FGF mAbs , indicating a specific FGF effect . Positive_regulation TNF FGF8 8384689 214821 We also found that significantly *enhanced* [TNF alpha] receptor expression . Positive_regulation TNF FGF8 8384689 214843 The mediated *increase* in [TNF alpha] receptor expression and TNF alpha mediated PGE2 production could be abolished by FGF mAbs , indicating a specific FGF effect . Positive_regulation TNF FGF9 8384689 214822 We also found that significantly *enhanced* [TNF alpha] receptor expression . Positive_regulation TNF FGF9 8384689 214844 The mediated *increase* in [TNF alpha] receptor expression and TNF alpha mediated PGE2 production could be abolished by FGF mAbs , indicating a specific FGF effect . Positive_regulation TNF FGFR3 20302876 2266005 In the in vitro studies treatment before hypoxia , *induced* a significant upregulation of [TNF-alpha] compared to the untreated cardiomyocytes . Positive_regulation TNF FGFR3 20857413 2375594 However , it is still unclear whether *regulates* [TNF-a] production in cardiomyocytes after hypoxia . Positive_regulation TNF FGFR3 25356117 2959881 Compared with I/R group , the expression of and a7nAchR protein significantly *increased* the [TNF-] and IL-6 levels decreased in STM group ( P < 0.05 ) . Positive_regulation TNF FGG 21439977 2421810 and FDP *promote* more protein expressions of IL-6 and [TNF-a] compared to iNOS , suggesting that fibrinogen and FDP produce a pro-inflammatory effect on VSMCs mainly by IL-6 and TNF-a . Positive_regulation TNF FLNA 9006895 410731 binds the stress activated protein kinase ( SAPK ) activator SEK-1 and is *required* for [tumor necrosis factor-alpha] activation of SAPK in melanoma cells . Positive_regulation TNF FLT3LG 11110682 757119 In this study , it is shown that short-term exposure of normal human marrow CD34 ( + ) CD38 ( - ) cells to low concentrations of [tumor necrosis factor (TNF)] in the *presence* of 100 ng/mL and Steel factor and 20 ng/mL interleukin-3 (IL-3) , IL-6 , and granulocyte colony stimulating factor , in either bulk or single-cell serum-free cultures , markedly reduces their ability subsequently to generate colony forming cells ( CFCs ) in 6-week stromal cell containing long-term cultures without affecting their viability , mitogenic response , or short-term ability to produce CFCs . Positive_regulation TNF FMR1 12921647 1130994 POF *induced* a dose dependent suppression of the spontaneous [TNF-alpha] release from AM in sarcoidosis ( P < 0.001 ) , while the spontaneous release of other cytokines was unaffected by at all tested concentrations , but a trend for the inhibition of IL-10 production was found ( P = 0.092 ) . Positive_regulation TNF FN1 11440974 833342 [Tumor necrosis factor-alpha] *induces* synthesis in coronary artery smooth muscle cells by a nitric oxide dependent posttranscriptional mechanism . Positive_regulation TNF FN1 12600740 1062298 The analysis of cytokine production has shown that the presence of laminin stimulated B-1b cells led to high levels of IL-10 production and and collagen *induced* the production of high levels of [TNF-alpha] . Positive_regulation TNF FN1 12628313 1066999 The increases in levels were 164 , 552 , 490 , 769 , 335 , 257 and 61 % at the corresponding times , but neither [tumor necrosis factor] nor interleukin-1 *increased* . Positive_regulation TNF FN1 18053242 1836232 LPS and [TNFalpha] *induced* collagen1 and levels as well as the matrix degradation enzyme MMP-1 . Positive_regulation TNF FN1 7648723 318997 markedly *stimulated* the secretion of IL-1 alpha , IL-1 beta , [TNF-alpha] and IL-6 from cultured monocytes in a dose dependent manner , with the maximal effect apparent within 24 h. Northern blot analysis revealed a marked increase in the abundance of mRNA specific for each monokine on exposure of monocytes to fibronectin . Positive_regulation TNF FN1 7648723 319000 These results indicate that *induced* production of IL-1 alpha , IL-1 beta , [TNF-alpha] and IL-6 from cultured monocytes is mediated predominantly by interaction of the cell binding domain of fibronectin with VLA-5 , although Mac-1 also may contribute to this effect of fibronectin . Positive_regulation TNF FN1 8705396 366015 Experiments were performed with PMN stimulated with either interleukin (IL)-8 , [tumor necrosis factor (TNF)-alpha] , or IL-1 beta in the *presence* or absence of . Positive_regulation TNF FN1 8871661 389609 Following H/R , both and laminin significantly *increased* [TNF-alpha] ( p60 , p80 ) and IL-8R expression . Positive_regulation TNF FOS 17424890 1723874 and c-Jun mRNAs were *induced* by [TNF-alpha] , and PD98059 ( MEK inhibitor ) and SB203580 ( p38 inhibitor ) abolished the up-regulation of c-Fos . Positive_regulation TNF FOS 17485464 1750564 We report that RANKL and [TNF] can *induce* osteoclast formation directly from NF-kappaB p50/p52 double knockout ( dKO ) osteoclast precursors when either or NFATc1 is expressed . Positive_regulation TNF FOS 18250170 1890714 [TNF] could *induce* expression in OCPs at sites of inflammation in bone to promote this autocrine mechanism and thus amplify bone loss . Positive_regulation TNF FOS 20141610 2178968 [TNF-alpha] *induced* increased levels of c-Jun and in the nucleus accompanied by phosphorylation of c-Jun . Positive_regulation TNF FOS 23553791 2804124 More interestingly , a long-term elevated levels of IFN-? and [TNF-a] *result* in significantly increased susceptibility to malignant transformation in MSCs through NF?B mediated upregulation of the oncogenes and c-Myc. Depletion of either IFN-? or TNF-a in OVX mice abolishes MSC impairment and the tendency toward malignant transformation with no NF?B mediated oncogene activation . Positive_regulation TNF FOS 23760290 2870592 Thus , dialysate TGF-ß1 , IL-1ß , and [TNF-a] *act* through to synergistically upregulate VEGF production in peritoneal mesothelium and may represent an important regulatory link between inflammation and angiogenesis in the peritoneal membrane . Positive_regulation TNF FOS 24386331 2883762 Because of an inability to evoke sufficient ERK activation and Elk-1 phosphorylation , [TNF-a] *induces* more weakly than PMA does in both mouse and human cells . Positive_regulation TNF FOXM1 22831955 2687270 In the current study , we demonstrated that [tumor necrosis factor (TNF)-aa] *induced* expression and transactivated its promoter activity in hepatoma cells . Positive_regulation TNF FOXO1 18701653 1974112 We used TNF treated C2C12 myotubes to test the hypothesis that signaling *mediates* [TNF] regulation of atrogin mRNA . Positive_regulation TNF FOXO1 21075101 2371466 [TNF-a] significantly *induced* the expression of in asymptomatic plaque SMCs in a dose- and time dependent manner via JNK signaling pathway . Positive_regulation TNF FOXO3 18701653 1974113 We used TNF treated C2C12 myotubes to test the hypothesis that signaling *mediates* [TNF] regulation of atrogin mRNA . Positive_regulation TNF FOXO3 19636295 2124544 [TNFalpha] *induces* the translocation of nuclear into the cytosol where it undergoes proteasomal degradation in human intestinal HT-29 cells . Positive_regulation TNF FPR2 19951729 2217341 MS did not *stimulate* the production of [tumor necrosis factor-alpha (TNF-alpha)] , nitric oxide , interleukin-10 (IL-10) , and transforming growth factor-beta1 ( TGF-beta1 ) by the M phi cells , whereas PSL MS stimulated all of these mediators except IL-10 . Positive_regulation TNF FST 23171678 2775234 is *induced* by IL-1ß and [TNF-a] in stromal cells from endometrioma . Positive_regulation TNF FSTL1 16783405 1599402 In contrast , S. aureus ( TLR2/TLR1/TLR6 ) or Pam ( 3 ) CSK4 ( TLR2/TLR1 ) , or and LTA ( TLR2/TLR6 ) *induced* [TNFalpha] without an effect on NO. 3 . Positive_regulation TNF FSTL1 20506332 2301236 could be *induced* in osteoblasts , adipocytes , and human fibroblast-like synoviocytes by TGFbeta , IL-1beta , [TNFalpha] , and IL-6 . Positive_regulation TNF FSTL1 21899704 2524733 The co-stimulation significantly suppressed *mediated* activation of NF-?B as well as production of [TNF-a] , IL-6 and IL-12p40 in a dose dependent manner . Positive_regulation TNF FTH1 8324080 223260 [TNF] did not *induce* the synthesis of in L929 cells . Positive_regulation TNF FURIN 17283058 1718387 *Role* for in [tumor necrosis factor] alpha induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway . Positive_regulation TNF FXR1 15548538 1367747 Fragile X-related protein *regulates* proinflammatory cytokine [tumor necrosis factor] expression at the post-transcriptional level . Positive_regulation TNF FXR1 15548538 1367750 Finally , we found that the ablation of FXR1P led to a dramatically enhanced association of the TNF mRNA with polyribosomes demonstrating the important *role* of in the post-transcriptional regulation of [TNF] expression . Positive_regulation TNF FXYD1 12825186 1104523 The ability of to *stimulate* [tumor necrosis factor (TNF)-alpha] production by J774 mouse cells correlates with the activation of nuclear factor (NF)-kappaB . Positive_regulation TNF FXYD1 20438293 2319810 , but not farnesol , *stimulated* [TNF-] & # x03B1 ; production , but neither PLM nor farnesol down modulated cytokine production in response to yeasts . Positive_regulation TNF FXYD1 24367694 2881825 Finally , we demonstrate that soluble and not cell surface bound galectin-3 , is able to potentiate *induced* [TNF-a] production in macrophages . Positive_regulation TNF GAB1 12065326 954391 Gab1 associated with MEKK3 , and a catalytically inactive form of MEKK3 inhibited TNF-alpha induced c-Jun and NF-kappaB transcriptional activation , suggesting a critical *role* for and MEKK3 in [TNF-alpha] signaling . Positive_regulation TNF GAD1 18761006 1993004 Stimulation with ( 65 ) *induced* higher levels of IL-6 , IFN-gamma , [TNF-alpha] and MIP-1alpha , whereas lower secretion was found for IL-10 and IL-13 in cryopreserved PBMC . Positive_regulation TNF GADD45A 22752116 2681934 *regulates* [TNF-a] and IL-6 synthesis in THP-1 cells . Positive_regulation TNF GADD45A 22752116 2681938 In contrast , over-expression of *increased* [TNF-a] production by six-fold and IL-6 protein by 80-fold . Positive_regulation TNF GADD45A 22752116 2681939 We show evidence that may *regulate* [TNF-a] and IL-6 expression in activated THP-1 monocyte cells . Positive_regulation TNF GAL 10221824 561284 Also , *increased* alanine aminotransferase ( ALT ) , aspartate aminotransferase (AST) , alkaline phosphatase and [TNF-alpha] in serum compared with the control group . Positive_regulation TNF GAL 10437800 634617 also *increased* [TNF] secretion . Positive_regulation TNF GAL 10498828 647701 Administration of a macrophage depletor , liposomes encapsulated with dichloromethylene bisphosphonate , reduced both the [TNF] production and mortality *induced* by . Positive_regulation TNF GAL 10498828 647702 4. Serum from LPS injected mice reduced the [TNF] production *induced* by , but it was less effective at reducing the lethality . Positive_regulation TNF GAL 12649350 1070532 NK-1R blockade clearly inhibited *induced* production of [TNFalpha] and IFNgamma , whereas synthesis of the hepatoprotective cytokines IL-6 and IL-10 was increased . Positive_regulation TNF GAL 15087472 1258125 [TNF-alpha] and IL-1 *induced* a time- and dose dependent increase in , vasoactive intestinal polypeptide , and secretogranin II mRNA levels . Positive_regulation TNF GAL 15196570 1260305 *augmented* the production of NO , but not [tumor necrosis factor (TNF)-alpha] in LPS stimulated RAW 264.7 cells . Positive_regulation TNF GAL 16051691 1438599 Histamine attenuated the *induced* increases in the levels of [TNF-alpha] , but augmented those of IL-10 both in the liver and serum . Positive_regulation TNF GAL 23298456 2742199 *increased* serum aminotransferase activity , serum [tumor necrosis factor-a] level and hepatic lipid peroxidation and decreased hepatic glutathione content . Positive_regulation TNF GAL 24065781 2902476 Unmodified siRNA transiently *induced* the expression of [TNF-a] , IL-6 , IL-10 , IFN-ß and IFN-sensitive gene 15 in vivo , whereas a formulation of 2'-O-methylated-LUC siRNA had no such effects . Positive_regulation TNF GAL 24565947 2929212 *increased* the circulating level of [TNF-a] and ATM-Kinase and MAP-Kinase expression . Positive_regulation TNF GAL 8618866 337605 Anti-lectin monoclonal antibodies 8C12 , H85 and 1G7 , which recognize nonoverlapping epitopes of the cysteine-rich region of the 170-kDa heavy subunit , inhibited both amebic adherence to mammalian cells and *stimulated* [TNF-alpha] mRNA expression by BMMs , but monoclonal antibody 7F4 did neither . Positive_regulation TNF GAL 9199414 438936 Native ( 100 to 500 ng/ml ) *stimulated* [TNF-alpha] and inducible nitric oxide synthase (iNOS) mRNA expression in IFN-gamma primed BMM as did lipopolysaccharide ( 100 ng/ml ) . Positive_regulation TNF GAL 9199414 438937 Primed BMM produced [TNF-alpha] and NO in *response* to in a dose dependent manner . Positive_regulation TNF GALT 21573722 2480878 It was reported that both SSeCKS and <ß-1,4-GalT-I> were *involved* in the LPS induced [tumor necrosis factor-alpha] ( TNF-a ) expression in rat primary astrocytes . Positive_regulation TNF GAST 22719247 2616424 Either DNA degradation by Sda1 or host deficiency of TLR9 prevented *induced* IFN-a and [TNF-a] secretion from murine macrophages and contributed to bacterial survival . Positive_regulation TNF GATA1 12972287 1139472 In addition , , NF-E1 , and ISRE were shown to be specifically *activated* by PMA but not [TNFalpha] . Positive_regulation TNF GATA2 12972287 1139473 In addition , , NF-E1 , and ISRE were shown to be specifically *activated* by PMA but not [TNFalpha] . Positive_regulation TNF GATA2 22499991 2595583 In mice with diabetes mellitus , excessive [tumor necrosis factor-a] *induced* miR-200b blunting proangiogenic functions of and VEGFR2 . Positive_regulation TNF GATA3 12972287 1139474 In addition , , NF-E1 , and ISRE were shown to be specifically *activated* by PMA but not [TNFalpha] . Positive_regulation TNF GATA4 12972287 1139475 In addition , , NF-E1 , and ISRE were shown to be specifically *activated* by PMA but not [TNFalpha] . Positive_regulation TNF GATA5 12972287 1139471 In addition , , NF-E1 , and ISRE were shown to be specifically *activated* by PMA but not [TNFalpha] . Positive_regulation TNF GATA6 12972287 1139476 In addition , , NF-E1 , and ISRE were shown to be specifically *activated* by PMA but not [TNFalpha] . Positive_regulation TNF GBP1 25272603 2958972 Recent studies have proved that IFN-alpha , IFN-beta , IFN-gamma , IL1alpha , IL1beta , [TNF-alpha] and LPS can *induce* expression ; Positive_regulation TNF GCLM 16011481 1459385 [TNFalpha] *induces* the expression and recombinant promoter activities of GCLC , and GSS in H4IIE cells . Positive_regulation TNF GCNT3 15864435 1401344 [TNF-alpha] *induced* expression of hST3GalIV , FUT3 , and MUC5AC mRNAs in NCI-H292 cells . Positive_regulation TNF GDF15 15897808 1408657 Although [TNF] *induced* expression , injury elicited Gdf15 expression was not reduced in mice deficient for both TNF receptor subtype . Positive_regulation TNF GDF15 16154591 1499440 Although [tumor necrosis factor (TNF)] *induced* expression , injury elicited Gdf15 expression was not reduced in mice deficient for both TNF receptor subtypes . Positive_regulation TNF GDNF 12935687 1031050 In the cerebellum , [TNF-alpha] was *induced* only in the granule cells , while expression was enhanced in the Purkinje cells . Positive_regulation TNF GDNF 16956589 1627645 In addition , we observe that not only exogenous [TNF-alpha] but also TNF-alpha produced by astrocytes *induce* NGF and production in astrocytes . Positive_regulation TNF GDNF 9545354 498605 These data indicate that the kappaB sites and the variant are *required* for [TNF-alpha] or LPS to optimally induce expression of the murine P-selectin gene . Positive_regulation TNF GH1 9854685 555023 Taking into account that can *increase* [TNF-alpha] and IL-1 secretion by mononuclear blood cells , the evaluation of possible relationship between the reduced BMD at lumbar spine and circulating cytokines levels was carried out in acromegalic patients . Positive_regulation TNF GIF 9409229 471380 In cultured human smooth muscle cells from coronary arteries and saphenous veins , [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 beta (IL-1 beta) *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ) , whereas selectively stimulated the expression of ICAM-1 . Positive_regulation TNF GJA1 12538692 1050250 [TNF-alpha] plus IFN-gamma *induce* expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses . Positive_regulation TNF GLA 1478920 207526 However , there was no inhibitory effect on *induced* production of IL-1 and [TNF] of macrophages . Positive_regulation TNF GLB1 15326480 1296849 The present study described that , in the leukemic KG1 cells , [TNFalpha] *induced* no apoptosis but a senescence state characterized by prolonged growth arrest , increased activity , p21WAF-1 induction , decreased telomerase activity , telomeric disturbances ( shortening , losses , fusions ) , and additional chromosomal aberrations . Positive_regulation TNF GLO1 17576200 1786136 We have previously shown that [TNF] ( tumour necrosis factor ) *induces* phosphorylation of ( glyoxalase I ) , which is required for cell death in L929 cells . Positive_regulation TNF GLO1 19199007 2049725 By using this phospho-specific antibody , we demonstrated that [TNF] *induces* phosphorylation of on Thr-106 . Positive_regulation TNF GLS 9133962 427359 In cultured fibroblast-like synoviocytes , [tumour necrosis factor-alpha (TNF-alpha)] , IL-1 , IL-6 and IL-8 *induced* expression . Positive_regulation TNF GNA12 10926555 718855 [TNF-alpha] *increases* transcription of in human airway smooth muscle cells . Positive_regulation TNF GNB1 12578117 1058204 We studied the ability of LPS and killed to *induce* [tumor necrosis factor (TNF)-alpha] and interleukin (IL) 10 , and of phytohemagglutinin ( PHA ) to induce interferon (IFN)-gamma , in whole blood from patients with sepsis ( SP , n = 20 ) , patients with matched underlying disease and without sepsis ( control patients , n = 20 ) , and healthy volunteers ( HV , n = 20 ) . Positive_regulation TNF GNB2 12578117 1058205 We studied the ability of LPS and killed to *induce* [tumor necrosis factor (TNF)-alpha] and interleukin (IL) 10 , and of phytohemagglutinin ( PHA ) to induce interferon (IFN)-gamma , in whole blood from patients with sepsis ( SP , n = 20 ) , patients with matched underlying disease and without sepsis ( control patients , n = 20 ) , and healthy volunteers ( HV , n = 20 ) . Positive_regulation TNF GNB2L1 12391233 1007318 Furthermore , activation of N-SMase by [TNF] was strongly *enhanced* when , FAN , and a noncytotoxic TNF-R55 mutant were expressed concurrently , suggesting RACK1 as a modulator of N-SMase activation . Positive_regulation TNF GNB3 12578117 1058206 We studied the ability of LPS and killed to *induce* [tumor necrosis factor (TNF)-alpha] and interleukin (IL) 10 , and of phytohemagglutinin ( PHA ) to induce interferon (IFN)-gamma , in whole blood from patients with sepsis ( SP , n = 20 ) , patients with matched underlying disease and without sepsis ( control patients , n = 20 ) , and healthy volunteers ( HV , n = 20 ) . Positive_regulation TNF GNB4 12578117 1058203 We studied the ability of LPS and killed to *induce* [tumor necrosis factor (TNF)-alpha] and interleukin (IL) 10 , and of phytohemagglutinin ( PHA ) to induce interferon (IFN)-gamma , in whole blood from patients with sepsis ( SP , n = 20 ) , patients with matched underlying disease and without sepsis ( control patients , n = 20 ) , and healthy volunteers ( HV , n = 20 ) . Positive_regulation TNF GNB5 12578117 1058207 We studied the ability of LPS and killed to *induce* [tumor necrosis factor (TNF)-alpha] and interleukin (IL) 10 , and of phytohemagglutinin ( PHA ) to induce interferon (IFN)-gamma , in whole blood from patients with sepsis ( SP , n = 20 ) , patients with matched underlying disease and without sepsis ( control patients , n = 20 ) , and healthy volunteers ( HV , n = 20 ) . Positive_regulation TNF GOLGA6L2 11306564 826881 Genistein , a specific inhibitor of tyrosine kinase , dramatically diminished both [TNF-alpha] secretion and subsequent MMP-9 release in *response* to or Abeta . Positive_regulation TNF GOT2 18678477 1960819 *regulates* LPS induced [TNF-alpha] production in mast cells . Positive_regulation TNF GP2 11292533 800852 The membrane associated form of the variable surface ( mfVSG ) from African trypanosomes is a potent macrophage *activator* capable of inducing production of [tumor necrosis factor alpha (TNFalpha)] in both bovine and murine models . Positive_regulation TNF GP2 1324245 194986 Macrophage membrane binding of Griffonia simplicifolia I-B4 *induces* [TNF-alpha] production and a tumoricidal response . Positive_regulation TNF GP2 7523521 272220 We propose instead an indirect mechanism of viral suppression of hematopoiesis as a result of [TNF-alpha] *induction* by virus or viral envelope . Positive_regulation TNF GP2 8482849 218880 We found that 120 , similar to LPS , *stimulates* the secretion of endothelin-1 , as well as [TNF-alpha] , from macrophages in a concentration dependent manner . Positive_regulation TNF GP2 9950266 589751 Alpha 1-acid *induced* [tumor necrosis factor-alpha] secretion of human monocytes is enhanced by serum binding proteins and depends on protein tyrosine kinase activation . Positive_regulation TNF GP5 11292533 800853 The membrane associated form of the variable surface ( mfVSG ) from African trypanosomes is a potent macrophage *activator* capable of inducing production of [tumor necrosis factor alpha (TNFalpha)] in both bovine and murine models . Positive_regulation TNF GP5 1324245 194987 Macrophage membrane binding of Griffonia simplicifolia I-B4 *induces* [TNF-alpha] production and a tumoricidal response . Positive_regulation TNF GP5 7523521 272221 We propose instead an indirect mechanism of viral suppression of hematopoiesis as a result of [TNF-alpha] *induction* by virus or viral envelope . Positive_regulation TNF GP5 8482849 218881 We found that 120 , similar to LPS , *stimulates* the secretion of endothelin-1 , as well as [TNF-alpha] , from macrophages in a concentration dependent manner . Positive_regulation TNF GP5 9950266 589752 Alpha 1-acid *induced* [tumor necrosis factor-alpha] secretion of human monocytes is enhanced by serum binding proteins and depends on protein tyrosine kinase activation . Positive_regulation TNF GP6 11292533 800851 The membrane associated form of the variable surface ( mfVSG ) from African trypanosomes is a potent macrophage *activator* capable of inducing production of [tumor necrosis factor alpha (TNFalpha)] in both bovine and murine models . Positive_regulation TNF GP6 1324245 194985 Macrophage membrane binding of Griffonia simplicifolia I-B4 *induces* [TNF-alpha] production and a tumoricidal response . Positive_regulation TNF GP6 7523521 272219 We propose instead an indirect mechanism of viral suppression of hematopoiesis as a result of [TNF-alpha] *induction* by virus or viral envelope . Positive_regulation TNF GP6 8482849 218879 We found that 120 , similar to LPS , *stimulates* the secretion of endothelin-1 , as well as [TNF-alpha] , from macrophages in a concentration dependent manner . Positive_regulation TNF GP6 9950266 589750 Alpha 1-acid *induced* [tumor necrosis factor-alpha] secretion of human monocytes is enhanced by serum binding proteins and depends on protein tyrosine kinase activation . Positive_regulation TNF GP9 11292533 800854 The membrane associated form of the variable surface ( mfVSG ) from African trypanosomes is a potent macrophage *activator* capable of inducing production of [tumor necrosis factor alpha (TNFalpha)] in both bovine and murine models . Positive_regulation TNF GP9 1324245 194988 Macrophage membrane binding of Griffonia simplicifolia I-B4 *induces* [TNF-alpha] production and a tumoricidal response . Positive_regulation TNF GP9 7523521 272222 We propose instead an indirect mechanism of viral suppression of hematopoiesis as a result of [TNF-alpha] *induction* by virus or viral envelope . Positive_regulation TNF GP9 8482849 218882 We found that 120 , similar to LPS , *stimulates* the secretion of endothelin-1 , as well as [TNF-alpha] , from macrophages in a concentration dependent manner . Positive_regulation TNF GP9 9950266 589753 Alpha 1-acid *induced* [tumor necrosis factor-alpha] secretion of human monocytes is enhanced by serum binding proteins and depends on protein tyrosine kinase activation . Positive_regulation TNF GPER1 20547845 2284906 A wholly synthetic <20-mer> peptide containing cysteine 106 from within the cytokine stimulating B box *mediates* TLR4 dependent activation of macrophage [TNF] release . Positive_regulation TNF GPI 11152670 810820 These novel interactions are coupled to previously demonstrated PTK and PKC pathways , since the specific inhibitors of these kinases effectively blocked the *induced* [TNF-alpha] production . Positive_regulation TNF GPI 11405554 825573 The effect of aspirin on prostanoid release was assessed in three individuals : PGE2 increased in all subjects , *increased* in two and remained unchanged in one , and TXA2 was reduced in two and unchanged in one individual The presence of DFU , a specific inhibitor of cyclooxygenase 2 , did not affect the reduction of [TNF-alpha] release by aspirin , but abolished prostanoid production in all three individuals . Positive_regulation TNF GPI 15238423 1322003 Strikingly , after stimulation with IgG-ICs , [tumor necrosis factor-alpha] release , dendritic cell maturation , and antigen presentation were strongly *reduced* by deficiency . Positive_regulation TNF GPI 16988223 1617885 Here we show that Pfj is able to down-regulate [tumor necrosis factor alpha (TNF-alpha)] production *induced* by the of P. falciparum . Positive_regulation TNF GPI 19135800 2037691 The also induced a prominent *increase* in IL-1beta and [TNF-alpha] levels in the DRG and of cyclooxygenase-2 (COX-2) expression in neurons and satellite cells . Positive_regulation TNF GPI 19359247 2081246 We show that MK2 differentially regulates the *induced* production of [TNF-alpha] and IL-12 . Positive_regulation TNF GPI 1940376 170605 The long term survival of peripheral blood derived human macrophages ( M phi ) from normal , healthy donors after infection with Mycobacterium avium intracellulare ( MAI ) correlates with the increased *induction* of [TNF-alpha] and IL-6 mRNA and protein by the infected M . Positive_regulation TNF GPI 22964479 2716011 Anti-ß ( 2 ) ( 2 ) GPI *induced* TF and [TNF-a] expression in monocytes involving both TLR4/MyD88 and TLR4/TRIF signaling pathways . Positive_regulation TNF GPI 22964479 2716014 Overall , our results indicate that anti-ß ( 2 ) GPI/ß ( 2 ) complex *induced* TF and [TNF-a] expression involving both TLR4/MyD88 and TLR4/TRIF signaling pathways and TLR4 and its adaptors might be molecular targets for therapy of antiphospholipid syndrome (APS) . Positive_regulation TNF GPI 24157085 2868194 Overall , our results indicate that complex *induced* IL-6 , IL-8 and [TNF-a] expression involving TLR4/MD-2/MyD88 and NF-?B signaling pathways and this might be associated with pathological mechanisms of antiphospholipid syndrome (APS) . Positive_regulation TNF GPI 24481129 2913247 Epigallocatechin-3-gallate inhibits TF and [TNF-a] expression *induced* by the complex in human THP-1 cells . Positive_regulation TNF GPI 24481129 2913249 In conclusion , our results indicate that EGCG decreases the *induced* TF and [TNF-a] expression in THP-1 cells possibly through the inhibition of the intracellular signal transduction pathway of TLRs-MAPKs-NF-?B axis and may serve as a preventive and therapeutic agent for antiphospholipid syndrome (APS) . Positive_regulation TNF GPI 2783642 106912 In this study , we demonstrate that human AM , as well as PBM , can be *induced* to express biologically active [TNF-alpha] after challenge with interleukin-2 (IL-2) . Positive_regulation TNF GPI 7579086 329695 It was found that clamping to values below 6.5 *led* to a markedly reduced [tumor necrosis factor-alpha] production and phagocytosis . Positive_regulation TNF GPI 7591712 334265 These data suggest that ( 1 ) [TNF-alpha] production , as other proteins , is *dependent* on the of monocytes , and ( 2 ) TNF-alpha production , in contrast to total protein , is modulated by Na ( + ) -dependent HCO3- . Positive_regulation TNF GPI 7791126 313298 Activation of murine bone marrow derived macrophages ( BMDM ) with lipopolysaccharide (LPS) *causes* rapid expression of [TNF-alpha] , which as an autocrine factor enhances BMDM phi function through IL-1 beta and IL-6 production . Positive_regulation TNF GPI 8022853 263162 We conclude that LPS stimulation of hp-M from liver disease *results* in similar production of IL-1 beta , IL-6 and [TNF-alpha] , but that the profile of the eicosanoid production of these M phi stimulated with LPS and A23187 differs from M phi of other origin and species . Positive_regulation TNF GPI 8397259 230464 Pretreatment with IL-6 induced a dose- and time dependent suppression of IFN-gamma ( 1000 U/mL ) and [TNF-alpha] ( 25 ng/mL ) *activation* of M for the killing of L. amazonensis . Positive_regulation TNF GPI 8596041 351174 The direct activation of endothelial cells by does not *require* the participation of [TNF] or IL-1 . Positive_regulation TNF GPI 9575350 408253 [TNF] and LPS each *induce* production in a concentration and time dependent manner . Positive_regulation TNF GPR1 15056724 1230043 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR101 15056724 1229999 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR107 15056724 1230004 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR108 15056724 1230003 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR110 15056724 1230009 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR111 15056724 1230010 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR112 15056724 1230011 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR113 15056724 1230008 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR114 15056724 1230012 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR115 15056724 1230013 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR116 15056724 1230014 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR119 15056724 1230015 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR12 15056724 1230044 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR123 15056724 1229996 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR124 15056724 1230005 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR125 15056724 1229997 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR126 15056724 1229998 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR128 15056724 1230016 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR132 15056724 1230002 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR133 15056724 1230017 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR135 15056724 1230018 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR137 15056724 1230036 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR139 15056724 1230019 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR141 15056724 1230020 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR142 15056724 1230021 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR143 15056724 1230022 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR144 15056724 1230007 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR146 15056724 1230024 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR148 15056724 1230028 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR149 15056724 1230030 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR15 15056724 1230045 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR150 15056724 1230031 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR151 15056724 1230029 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR152 15056724 1230027 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR153 15056724 1230026 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR155 15056724 1230025 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR156 15056724 1230023 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR157 15056724 1230032 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR158 15056724 1230033 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR160 15056724 1230034 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR161 15056724 1230035 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR162 15056724 1230000 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR17 15056724 1230046 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR171 15056724 1230038 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR173 15056724 1230006 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR174 15056724 1230039 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR176 15056724 1230042 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR179 15056724 1230041 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR18 15056724 1230047 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR180 15056724 1230037 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR182 15056724 1229994 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR183 15056724 1230040 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR19 15056724 1230048 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR20 15056724 1230049 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR21 15056724 1230050 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR22 15056724 1230051 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR25 15056724 1230052 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR26 15056724 1230053 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR27 15056724 1230054 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR3 15056724 1230055 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR31 15056724 1230056 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR32 15056724 1230057 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR33 15056724 1230058 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR34 15056724 1230059 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR35 15056724 1230060 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR36 15056724 1230061 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR37 15056724 1230062 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR39 15056724 1230063 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR4 15056724 1230064 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR42 15056724 1230065 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR45 15056724 1230066 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR50 15056724 1230067 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR52 15056724 1230068 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR55 15056724 1230069 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR56 15056724 1230070 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR6 15056724 1230071 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR61 15056724 1229991 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR62 15056724 1229992 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR63 15056724 1229993 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR64 15056724 1230072 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR65 15056724 1230073 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR68 15056724 1230074 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR75 15056724 1230076 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR78 15056724 1230077 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR79 15056724 1230078 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR82 15056724 1230079 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR83 15056724 1230075 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR84 15056724 1230080 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR85 15056724 1230081 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR87 15056724 1230082 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR88 15056724 1230083 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR97 15056724 1229995 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPR98 15056724 1230001 We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above , Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release , and at subthreshold doses , Abeta indirectly potentiated [TNF-alpha] release *induced* by certain activators . Positive_regulation TNF GPX1 20112906 2206334 SOD and expressions decreased ( p < 0.001 ) but that of [TNFalpha] *increased* significantly ( P < 0.001 ) in FT rats with respect to FC and NFT animals . Positive_regulation TNF GPX2 20112906 2206335 SOD and expressions decreased ( p < 0.001 ) but that of [TNFalpha] *increased* significantly ( P < 0.001 ) in FT rats with respect to FC and NFT animals . Positive_regulation TNF GPX3 20112906 2206336 SOD and expressions decreased ( p < 0.001 ) but that of [TNFalpha] *increased* significantly ( P < 0.001 ) in FT rats with respect to FC and NFT animals . Positive_regulation TNF GPX4 20112906 2206337 SOD and expressions decreased ( p < 0.001 ) but that of [TNFalpha] *increased* significantly ( P < 0.001 ) in FT rats with respect to FC and NFT animals . Positive_regulation TNF GPX5 20112906 2206338 SOD and expressions decreased ( p < 0.001 ) but that of [TNFalpha] *increased* significantly ( P < 0.001 ) in FT rats with respect to FC and NFT animals . Positive_regulation TNF GPX6 20112906 2206339 SOD and expressions decreased ( p < 0.001 ) but that of [TNFalpha] *increased* significantly ( P < 0.001 ) in FT rats with respect to FC and NFT animals . Positive_regulation TNF GPX7 20112906 2206340 SOD and expressions decreased ( p < 0.001 ) but that of [TNFalpha] *increased* significantly ( P < 0.001 ) in FT rats with respect to FC and NFT animals . Positive_regulation TNF GPX8 20112906 2206333 SOD and expressions decreased ( p < 0.001 ) but that of [TNFalpha] *increased* significantly ( P < 0.001 ) in FT rats with respect to FC and NFT animals . Positive_regulation TNF GRAP2 10201904 605664 [TNF-alpha] *induced* tyrosine phosphorylation and enzymatic activation of ERK2 , SAPK/JNK , and , whereas IL-10 did not induce these events . Positive_regulation TNF GRAP2 10329111 613022 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , , and MAPK . Positive_regulation TNF GRAP2 10445612 636210 Inhibition of TNF-alpha- and IL-1alpha induced MAP kinase activity by SB 203580 *inhibited* [TNF-alpha-] and IL-1alpha induced IL-8 protein production as well as IL-8 messenger ribonucleic acid ( mRNA ) expression , indicating that SB 203580 was effective at the transcriptional level . Positive_regulation TNF GRAP2 10495353 647132 Subsequent downstream events triggered by activation *result* in the production of IL-1 and [TNF-a] , suggesting that inhibition of this enzyme may provide a useful therapeutic target for intervention in various diseases mediated by these cytokines . Positive_regulation TNF GRAP2 10525088 653899 Monocyte/macrophage production of [TNF-alpha] is *dependent* on the mitogen activated protein kinase . Positive_regulation TNF GRAP2 10781614 714393 Like IL-6 , [TNF-alpha] , which activates both NF-kappaB and p38 , also *induced* dependent IL-6 expression and release and protected myocytes from apoptotis . Positive_regulation TNF GRAP2 10991908 732885 The kinase inhibitor , SB 203580 *inhibits* [TNF-alpha] and IL-1beta production in vitro and in vivo . Positive_regulation TNF GRAP2 11443055 833775 Furthermore , 60 min of ischemia induced renal tubular cell apoptosis at all substrate replacement time points examined , with peak apoptotic cell death occurring after either 24 or 48 h . p38 MAPK inhibition abolished [TNF-alpha] mRNA production and TNF-alpha bioactivity , and both MAPK inhibition and TNF-alpha neutralization ( anti-porcine TNF-alpha antibody ) *prevented* apoptosis after 60 min of SI . Positive_regulation TNF GRAP2 12133965 967054 Selective inhibitors of ERK 1/2 ( PD98059 or U0126 ) , ( SB203580 ) , or NF-kappa B ( caffeic acid phenetyl ester ( CAPE ) ) could all significantly *reduce* [TNF-alpha] production , although none of the inhibitors used alone was able to completely prevent TNF-alpha release . Positive_regulation TNF GRAP2 12270697 990954 The effect of TNF alpha was dependent on the p55 [TNF alpha] receptor and *activation* of MAP kinase . Positive_regulation TNF GRAP2 12464556 1022198 kinase inhibitor SB 203580 *inhibits* IL-1beta- and [TNF-alpha-synthesis] ( IC ( 50 ) sof 0.052 microM and 0.46 microM ) in the same degree as p38-MAP kinase activity ( IC ( 50 ) : 0.34 microM ) . Positive_regulation TNF GRAP2 12637577 1099249 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and [tumor necrosis factor alpha (TNFalpha)] *requires* MAPK activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation TNF GRAP2 12637577 1099332 This strategy established the *requirement* for activity for the lipopolysaccharide stimulated production of IL-10 , IL-1beta , and IL-6 by the monocytic cell WEHI 274 and the production of IL-6 and [TNFalpha] stimulated by ligation of the Fc-gamma receptor of the mast cell MC/9 . Positive_regulation TNF GRAP2 12797541 1098687 Using highly specific inhibitors of p38 ( SB203580 ) and of MAPK kinase-1 ( U0126 and PD98059 ) , we found that both and ERK were *essential* for M. tuberculosis H37Rv induced [TNF-alpha] production , whereas activation of the p38 pathway , but not that of ERK , was essential for M. tuberculosis H37Rv induced IL-10 production . Positive_regulation TNF GRAP2 12960156 1158188 IFNgamma *induced* MMP-1 in the presence of GM-CSF through the stimulation of [TNFalpha] production through a mechanism involving both p38 and ERK1/2 MAPKs , in which GM-CSF stimulated ERK1/2 whereas IFNgamma activated . Positive_regulation TNF GRAP2 12969251 1139146 Inhibition of the MAP-kinase-kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) pathway , but not that of mitogen activated protein ( MAPK-p38 ) , *reduced* NO , [TNF-alpha] and IL-6 significantly , suggesting that simultaneous activation of the first two pathways is necessary for the AGE induced induction of these pro-inflammatory stimuli . Positive_regulation TNF GRAP2 14654378 1176809 These findings suggest that the pre-ischemic *activation* of by [TNF] does not contribute to cardioprotection afforded by this agent . Positive_regulation TNF GRAP2 14980980 1220288 The selective MAPK inhibitor , SB203580 , *inhibited* the promoter activities of iNOS and COX-2 rather than that of [TNF-alpha] . Positive_regulation TNF GRAP2 15050407 1229347 P38 mediated caspase activation regulates mercury induced apoptosis and *mediated* [TNFalpha] regulates necrosis in these cells . Positive_regulation TNF GRAP2 15321739 1286612 Activation of adenosine receptors *inhibits* [tumor necrosis factor-alpha] release by decreasing TNF-alpha mRNA stability and activity . Positive_regulation TNF GRAP2 15332391 1290941 Physiological parameters , [tumour necrosis factor (TNF)-alpha] , interleukin (IL)-8 and *activation* of mitogen activated protein kinases ( extracellular signal regulated kinase ( ERK ) 1/2 , and stress activated protein kinase ( SAPK ) / c-Jun N-terminal kinase (JNK) ) were measured . Positive_regulation TNF GRAP2 15365619 1334208 Rosiglitazone treatment impaired [TNF-alpha] *activation* of and p42/p44MAPK , restoring insulin signalling and leading to normalisation of glucose uptake . Positive_regulation TNF GRAP2 15611045 1375325 Furthermore , is critical for the production of IL-6 and IL-12 but is only marginally *required* for the production of [TNF-alpha] and nitric oxide . Positive_regulation TNF GRAP2 15696199 1382712 Normal flow inhibited [TNF] *activation* of and VCAM1 expression . Positive_regulation TNF GRAP2 15696199 1382730 In cultured ECs , reduction of TXNIP expression by small interfering RNA increased TRX binding to ASK1 and inhibited [TNF] *activation* of and VCAM1 expression . Positive_regulation TNF GRAP2 15701814 1416522 MAPK activation *leads* to increased production of [TNF-alpha] in ischemic injury and in macrophages . Positive_regulation TNF GRAP2 15701814 1416549 Inhibition of MAPK activation *led* to inhibition of [TNF-alpha] production . Positive_regulation TNF GRAP2 15775695 1397289 We hypothesize that bile-pancreatic juice exclusion activates ( MAPK ) and *induces* [TNF-alpha] production in ligation induced acute pancreatitis . Positive_regulation TNF GRAP2 15857937 1432694 Using the specific p38 inhibitor ( SB203580 ) , we confirmed that the increase in [tumor necrosis factor] alpha production by LPS stimulated burn macrophages *requires* activation . Positive_regulation TNF GRAP2 15867183 1404195 In cultured cardiac myocytes , specific activation of stress activated mitogen activated protein kinase , , by upstream activator MKK6bE *led* to significant induction of [tumor necrosis factor-alpha] and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation TNF GRAP2 15893422 1419726 We also investigated whether specific inhibition of and Erk1/2 MAPK would *inhibit* [TNF-alpha] and IL-6 production and thus astrocyte apoptosis , and proliferation , respectively . Positive_regulation TNF GRAP2 15893422 1419755 In contrast , inhibition of both and Erk1/2 significantly *diminished* [TNF-alpha] production , and totally abrogated production of this cytokine when both MAPK pathways were inhibited simultaneously . Positive_regulation TNF GRAP2 16081599 1460331 These results indicate that gp120 elicited TNF-alpha production by macrophages involves chemokine receptor mediated PI-3K and MAPK activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that and ERK-1/2 independently *regulate* [TNF-alpha] production . Positive_regulation TNF GRAP2 16160917 1456080 The analysis of cytokine production using specific inhibitors of the MAPK pathway revealed that both and ERK activation are *essential* for PPD induced [TNF-alpha] production , whereas p38 , but not ERK , activation is essential for IL-10 secretion . Positive_regulation TNF GRAP2 16297883 1502777 Furthermore , the ERK , , JNK , and NF-kappaB mediated pathways are all *involved* in dioscorin mediated [TNF-alpha] production . Positive_regulation TNF GRAP2 16871588 1593190 Inhibition of and NF-kappaB activation by SB203580 and pyrrolidine dithiocarbamate , respectively , *blocked* endotoxin induced H ( 2 ) O ( 2 ) , NO , [TNF-alpha] , and IL-6 synthesis . Positive_regulation TNF GRAP2 16871588 1593196 In conclusion , endotoxin induced synthesis of NO , [TNF-alpha] , and IL-6 in HSCs is *mediated* by and NF-kappaB , with involvement of H ( 2 ) O ( 2 ) in TNF-alpha production . Positive_regulation TNF GRAP2 16953659 1646561 Activation of *required* [tumor necrosis factor alpha (TNFalpha)] in the nervous system because IT etanercept ( a TNF inhibitor ) given during adjuvant arthritis blocked spinal p38 phosphorylation and reduced clinical signs of adjuvant arthritis . Positive_regulation TNF GRAP2 16954198 1615716 Furthermore , using a kinase array , p38alpha was found to mediate LITAF phosphorylation and the inhibition of with a p38-specific inhibitor ( SB203580 ) blocked LITAF nuclear translocation and *reduced* LPS induced [TNF-alpha] protein levels . Positive_regulation TNF GRAP2 17018860 1682945 By contrast , we also place RhoA downstream of p38 mitogen activated protein kinase and Cdc42 in a novel LPS activated pathway in which , Cdc42 , and ROCKalpha all *promote* [TNFalpha] protein expression . Positive_regulation TNF GRAP2 17151142 1732364 To fully evaluate the role of TNF-alpha in myogenic activation of p38 , we tried to determine whether activation in differentiating myoblasts *requires* autocrine [TNF-alpha] , and whether forced activation of p38 rescues impaired myogenesis and regeneration in the p55 ( -/- ) p75 ( -/- ) soleus . Positive_regulation TNF GRAP2 17189827 1680181 IL6RIL6 or [IL6RIL6/TNFalpha-inducible] AP-1 binding increase was supershifted by anti-c-Jun or c-Fos antibodies , and the activation of c-Jun and c-Fos was *dependent* on JNK and , respectively . Positive_regulation TNF GRAP2 17223661 1765545 Predominant *activation* of MAP kinases and pro-destructive/pro-inflammatory features by [TNF alpha] in early-passage synovial fibroblasts via TNF receptor-1 : failure of inhibition to suppress matrix metalloproteinase-1 in rheumatoid arthritis . Positive_regulation TNF GRAP2 17456758 1730219 Vitamin administration or pathway inhibition also *reduced* cyclooxygenase-2 expression , [tumor necrosis factor-alpha] and interleukin-1 beta secretion , and the levels of apoptosis . Positive_regulation TNF GRAP2 17763449 1801854 Furthermore , APC directly suppressed the production of [tumor necrosis factor (TNF)] and the activation of NF-kappaB and MAP kinase p38 , and inhibitors of NF-kappaB or *reduced* the production of MMP-9 , suggesting that APC inhibits MMP-9 by blocking TNF , NF-kappaB , and p38 . Positive_regulation TNF GRAP2 18255061 1877211 Furthermore , the induction of HIF-1alpha in mice with endotoxemia suggested a synergistic effect on *mediated* [TNF-alpha] expression . Positive_regulation TNF GRAP2 18296636 1878854 Whereas the induction of [TNFalpha] , IL-1beta , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation TNF GRAP2 18303184 1873517 Inhibition of MAPK activation selectively *blocked* DNCB induced [TNF-alpha] release , but not NiSO ( 4 ) -induced release . Positive_regulation TNF GRAP2 18799179 1981138 Inhibition of and JNK/SAPK *reduced* PRV induced [TNF-alpha] up-regulation . Positive_regulation TNF GRAP2 18805401 1981234 An analysis of distinct signaling pathway activations then revealed an *activation* of by [TNF] , as well as a corresponding involvement of this mitogen activated protein kinase (MAPK) in the cytokine dependent inhibition of erythroid differentiation . Positive_regulation TNF GRAP2 18949619 1982403 Furthermore , inhibition *diminishes* the expression of [TNFalpha] or IL-1beta induced proinflammatory chemokines in BM stromal cells . Positive_regulation TNF GRAP2 19002259 1991225 Peptidoglycan stimulated monocyte p38 mitogen activated protein kinase and activity was *required* for [TNFalpha] production by the cells . Positive_regulation TNF GRAP2 19220841 2039626 A inhibitor *reduced* U18666A induced [TNF-alpha] production . Positive_regulation TNF GRAP2 19733186 2147106 Pre-treatment with C-K significantly inhibited zymosan mediated secretion of [tumor necrosis factor-alpha] , interleukin (IL)-6 , and IL-12 p40 , and the *activation* of ERK1/2 and . Positive_regulation TNF GRAP2 19751557 2135270 p38MAPK 's phosphorylation is important in pathogenesis of MODS , and phosphorylation of can *enhance* TNF-alpha mRNA transcription and secretion of [TNF-alpha] from peripheral blood mononuclear cells , which is the mechanism of increased TNF-alpha in MODS . Positive_regulation TNF GRAP2 19778233 2141047 The induction of [TNF-alpha] and TGF-beta1 by silica was *suppressed* by Src inhibitor ( PP1 ) , ERK inhibitor ( PD98059 ) , but not by kinase inhibitor ( SB203580 ) . Positive_regulation TNF GRAP2 19801900 2148230 Vaspin did not inhibit the [TNF-alpha] ( 20 min ) *activation* of JNK , and NF-kappaB , but only slightly inhibited Akt . Positive_regulation TNF GRAP2 19838780 2216988 In the present study , production of [TNF-alpha] and MIP-2 and *activation* of extracellular signal regulated kinases ( ERK ) 1/2 , c-Jun amino terminal kinases (JNK) and in RAW264.7 cells were measured . Positive_regulation TNF GRAP2 19938896 2190511 MEHP also induced phosphorylation of MAPK p38 , while the inhibitor SB 202190 *reduced* MEHP induced [TNF-alpha] , suggesting a p38 dependent cytokine production . Positive_regulation TNF GRAP2 20446028 2395177 Our results suggest that *contributes* directly to [TNF-a] production in human whole blood while playing a negative regulatory role in rat blood which can be overridden by p38 inhibition in the presence of high stimulus concentration . Positive_regulation TNF GRAP2 20606319 2286343 A inhibitor , SB203580 , also *inhibited* the [TNFalpha] production dose-dependently . Positive_regulation TNF GRAP2 20851927 2388992 Inhibition of , but not ERK , *attenuated* production of both IL12/IL23p40 and [TNF-a] . Positive_regulation TNF GRAP2 21314908 2393324 Administration of an inhibitor specific to p38 or JNK resulted in varying degrees of attenuation on ApxI induced cytokine expression , suggesting the differential regulatory *roles* of and JNK in IL-1ß , IL-8 and [TNF-a] production . Positive_regulation TNF GRAP2 21895414 2491674 The inhibitor SB203580 or the JNK inhibitor SP600125 *inhibited* the AFS induced NO and [TNF-a] production . Positive_regulation TNF GRAP2 22022968 2499138 [TNF-a] production by both strains was *reduced* in the presence of specific inhibitors of mitogen activated protein kinase kinase-1 ( PD98059 ) , ( SB203580 ) , and NF-?B ( BAY 11-7082 ) . Positive_regulation TNF GRAP2 22083995 2508690 The inhibition of iNOS , [TNF-a] and IL-6 by the chloroform fraction may be partly *due* to the suppression of , JNK and ERK1/2 . Positive_regulation TNF GRAP2 22143055 2536453 Experiments using specific inhibitors suggested that MEHP induced activation of both and the phosphoinositide-3 (PI3) kinase/Akt pathway were *involved* in the release of [TNF-a] ; Positive_regulation TNF GRAP2 22301607 2580352 and ERK1/2 *regulate* LPS induced [IL-6/TNF-a] expression through an NF-?B dependent manner and an NF-?B independent manner , respectively . Positive_regulation TNF GRAP2 22744777 2853441 After LPS administration , all animals displayed increased arterial carbon dioxide partial pressure ( PaCO2 ) and decreased arterial oxygen partial pressure ( PaO2 ) , arterial oxygen saturation ( SO2 ) , HCO3 ( - ) concentration and pH , and *increased* LWCI , MPO activity , interleukin (IL)-1ß , IL-6 and [tumor necrosis factor (TNF)-a] mRNA expression , NF-?B p65 positive staining and MAPK activation compared with normal controls ( all P < 0.01 ) . Positive_regulation TNF GRAP2 24247374 2879608 Pharmacological inhibitors of and ERK1/2 partly *attenuated* IL-17A induced [TNF-a] , IL-1ß , and IL-6 production . Positive_regulation TNF GRAP2 8940070 398853 In HeLa cells containing an integrated HIV-1 long terminal repeat ( LTR ) -driven reporter , we now show that the specific inhibitor , SB203580 , *inhibits* activation of the HIV-1 LTR by interleukin-1 , [tumor necrosis factor] , UV light , and osmotic stress . Positive_regulation TNF GRAP2 9006914 410765 [TNFalpha] stimulation of endothelial cells induces transient phosphorylation of both ATF-2 and c-JUN and *induces* marked activation of the c-JUN N-terminal kinase ( JNK1 ) and but not extracellular signal regulated kinase ( ERK1 ) . Positive_regulation TNF GRAP2 9579682 503399 Both inhibitors of ( SB203580 ) and ERK pathway ( PD098059 ) *reduced* LPS induced nitric oxide ( NO ) release and Abeta induced [tumor necrosis factor-alpha (TNF-alpha)] release . Positive_regulation TNF GRAP2 9706151 526169 We hypothesized that hydrogen peroxide ( H2O2 ) induces myocardial dysfunction and cardiomyocyte death via mitogen activated protein kinase (MAPK) *mediated* myocardial [tumor necrosis factor (TNF)] production . Positive_regulation TNF GRAP2 9706165 526261 Both LPS and [TNF-alpha] *induced* activation of in HMVECs . Positive_regulation TNF GRAP2 9766635 538478 [TNF-alpha] and GM-CSF priming of superoxide release stimulated by N-formyl-methionyl-leucyl-phenylalanine was significantly *attenuated* by the MEK inhibitor , PD098059 , and the MAPK inhibitor , SB203580 . Positive_regulation TNF GRAP2 9864164 582557 A selective MAPK inhibitor , SB203580 , *blocked* [TNF] -- or ceramide induced CREB phosphorylation , but had no effect on the induction of apoptosis mediated by these agents . Positive_regulation TNF GRN 11676011 873408 These facts strongly suggested that insoluble as well as a high molecular mass soluble form of are *required* for [TNF] production by macrophages . Positive_regulation TNF GSK3B 12584189 1079362 Ectopic expression of *increased* both basal and [tumor necrosis factor] alpha stimulated activities of MEKK1 in GSK3 beta ( -/- ) cells . Positive_regulation TNF GSK3B 16601113 1568696 Overexpression of in endothelial cells , in contrast , significantly *inhibited* ( by 70 % , p < 0.01 ) both [TNF-alpha] and IL-1beta induced expression of IL-6 , MCP-1 , and vascular cell adhesion molecule-1 . Positive_regulation TNF GSK3B 18027881 1894624 This study was to investigate the *role* of ( GSK-3beta ) in cardiomyocyte [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Positive_regulation TNF GSK3B 18027881 1894631 Further evidence to support the inhibitory *role* of in [TNF-alpha] expression is that protein kinase B ( Akt ) signaling , an upstream inhibitor of GSK-3beta , promotes TNF-alpha expression in LPS stimulated cardiomyocytes and this action of Akt signaling can be mimicked by GSK-3beta inactivation . Positive_regulation TNF GSK3B 19596777 2122958 These results suggest that *regulates* heat inactivated S. aureus induced [TNF-alpha] and NO production in microglia mainly by activating NF-kappaB and probably by inhibiting IL-10 . Positive_regulation TNF GSTM1 9278181 450827 and MTX *augmented* spontaneous [TNF alpha] production in normal individuals and patients with RA but did not influence LPS stimulated TNF alpha production . Positive_regulation TNF GSTM2 9278181 450828 and MTX *augmented* spontaneous [TNF alpha] production in normal individuals and patients with RA but did not influence LPS stimulated TNF alpha production . Positive_regulation TNF GSTM3 9278181 450829 and MTX *augmented* spontaneous [TNF alpha] production in normal individuals and patients with RA but did not influence LPS stimulated TNF alpha production . Positive_regulation TNF GSTM4 9278181 450830 and MTX *augmented* spontaneous [TNF alpha] production in normal individuals and patients with RA but did not influence LPS stimulated TNF alpha production . Positive_regulation TNF GSTM5 9278181 450831 and MTX *augmented* spontaneous [TNF alpha] production in normal individuals and patients with RA but did not influence LPS stimulated TNF alpha production . Positive_regulation TNF GTF2B 9833740 552026 Interleukin-10 enhances [tumor necrosis factor-alpha] *activation* of in latently infected T cells . Positive_regulation TNF GTF2B 9833740 552029 Taken collectively , these data suggest that IL-10 enhances suboptimal [TNF-alpha] *activation* of in chronically infected T-cells at least in part through induction of endogenous TNF-alpha expression . Positive_regulation TNF GZMB 1721015 171712 <145-2C11> *induced* significant release of [TNF] and IL-2 in all four strains . Positive_regulation TNF GZMB 19458908 2115466 [TNF-alpha] *induced* MCP-1 , RANTES , and production in cultured synovial cells from RA patients . Positive_regulation TNF GZMB 2138564 128995 The release of [TNF] *induced* by <145-2C11> depends on the effect of the mAb on T cells as it is not observed in athymic nude mice while lipopolysaccharide-resistant C3H/HeJ mice also display a significant rise in serum TNF ( peak levels at 2 h : 59 +/- 44 pg/ml ) . Positive_regulation TNF H2AFX 24036252 2857185 The ensuing Slug dependent serine 139 phosphorylation of the DNA damage sensor in breast cancer stem cells *induces* [tumor necrosis factor-a] and IL-8 mRNAs , whose stability is enhanced by cytoplasmic ß-catenin . Positive_regulation TNF H6PD 8823382 384889 [TNF alpha] and IL-1 alpha *induced* an increase in promoter activity in C8S ( an astrocytic cell line ) transfected with constructs containing 5 ' flanking genomic sequences of GDH driving the expression of a reporter gene . Positive_regulation TNF HAS1 18444484 1900653 IL-1beta and [TNF-alpha] *induced* each other and synergistically increased and HAS-2 expression . Positive_regulation TNF HAS2 18444484 1900654 IL-1beta and [TNF-alpha] *induced* each other and synergistically increased HAS-1 and expression . Positive_regulation TNF HAVCR2 19676072 2132862 In addition , human CD4 ( + ) T cells secreted elevated levels of IFN-gamma , IL-17 , IL-2 , and IL-6 , but not IL-10 , IL-4 , or [TNF-alpha] , when stimulated with anti-CD3/anti-CD28 in the *presence* of , putative antagonistic antibodies . Positive_regulation TNF HBD 19477909 2142268 Both defensins promoted the activation and maturation of moDCs , as assessed by up-regulation of surface expression of the costimulatory molecules CD80 , CD86 , and CD40 , the maturation marker CD83 , and HLA-DR . HNP-1 and also *enhanced* the production of the proinflammatory cytokines [TNF-alpha] , IL-6 , and IL-12p70 but did not affect the production of the regulatory cytokine IL-10 . Positive_regulation TNF HCL1 18651847 1967041 At 2 h , minocycline *induced* high levels of IL-10 , [TNFalpha] and IFNgamma , while CHX reduced the levels of TNFalpha and IFNgamma . Positive_regulation TNF HCL2 18651847 1967042 At 2 h , minocycline *induced* high levels of IL-10 , [TNFalpha] and IFNgamma , while CHX reduced the levels of TNFalpha and IFNgamma . Positive_regulation TNF HCL3 18651847 1967043 At 2 h , minocycline *induced* high levels of IL-10 , [TNFalpha] and IFNgamma , while CHX reduced the levels of TNFalpha and IFNgamma . Positive_regulation TNF HDAC1 14599803 1161391 We found that the inhibitors ( phenylbutyrate and trichostatin A ) causing histone hyperacetylation to modulate multiple gene expression not only induced the expression of p21 ( Cip1 ) and p16(INK4) in synovial cells but also *inhibited* the expression of [tumor necrosis factor-alpha] in affected tissues in adjuvant arthritis , an animal model of RA . Positive_regulation TNF HDAC1 15063780 1230943 The inhibitors butyrate and TSA *blocked* the [TNF-alpha] activation of Cox-2 protein and mRNA synthesis , and dramatically suppressed Cox-2 activity in HT-29 cells . Positive_regulation TNF HDAC2 14599803 1161392 We found that the inhibitors ( phenylbutyrate and trichostatin A ) causing histone hyperacetylation to modulate multiple gene expression not only induced the expression of p21 ( Cip1 ) and p16(INK4) in synovial cells but also *inhibited* the expression of [tumor necrosis factor-alpha] in affected tissues in adjuvant arthritis , an animal model of RA . Positive_regulation TNF HDAC2 15063780 1230944 The inhibitors butyrate and TSA *blocked* the [TNF-alpha] activation of Cox-2 protein and mRNA synthesis , and dramatically suppressed Cox-2 activity in HT-29 cells . Positive_regulation TNF HDAC3 16371367 1519654 Regulation of nuclear translocation of by IkappaBalpha is *required* for [tumor necrosis factor] inhibition of peroxisome proliferator activated receptor gamma function . Positive_regulation TNF HDAC3 17456789 1761124 An interaction of and silencing mediator for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF HDC 1385320 200742 IL-1 alpha , IL-1 beta , [TNF alpha] and TNF beta *induced* and ODC , as does LPS . Positive_regulation TNF HDC 15820445 1393585 In addition , the systemic effect on serum cytokine levels showed that only moderately lowered IL-2 *induced* IFN-gamma , IL-6 , IL-10 , IL-18 and [TNF-alpha] . Positive_regulation TNF HES1 18434912 1900282 Glass capillaries were coated internally with either purified adhesion molecules or HUVEC , which were treated with [tumor necrosis factor-alpha] in the *presence* or absence of . Positive_regulation TNF HES1 19910630 2189363 HK-2 cells were stimulated with [TNF-alpha] in the *presence* or absence of 130/0.42 or 200/0.5 . Positive_regulation TNF HES1 19910630 2189370 TNF-alpha stimulation resulted in a significant decrease of viability by 53 % -63 % , whereas viability decreased by only 32 % -40 % in coincubation with HES 130/0.42 ( P < 0.005 ) and remained even less affected by [TNF-alpha] in the *presence* of 200/0.5 ( P < 0.001 ) . Positive_regulation TNF HES1 23245375 2711189 improved liver microcirculation , cardiac index and DO ( 2 ) -I , but significantly *increased* IL-1ß , IL-6 and [TNF-a] levels and resulted in a mortality rate of 33 % . Positive_regulation TNF HES2 18434912 1900277 Glass capillaries were coated internally with either purified adhesion molecules or HUVEC , which were treated with [tumor necrosis factor-alpha] in the *presence* or absence of . Positive_regulation TNF HES2 19910630 2189358 HK-2 cells were stimulated with [TNF-alpha] in the *presence* or absence of 130/0.42 or 200/0.5 . Positive_regulation TNF HES2 19910630 2189365 TNF-alpha stimulation resulted in a significant decrease of viability by 53 % -63 % , whereas viability decreased by only 32 % -40 % in coincubation with HES 130/0.42 ( P < 0.005 ) and remained even less affected by [TNF-alpha] in the *presence* of 200/0.5 ( P < 0.001 ) . Positive_regulation TNF HES2 23245375 2711184 improved liver microcirculation , cardiac index and DO ( 2 ) -I , but significantly *increased* IL-1ß , IL-6 and [TNF-a] levels and resulted in a mortality rate of 33 % . Positive_regulation TNF HES3 18434912 1900281 Glass capillaries were coated internally with either purified adhesion molecules or HUVEC , which were treated with [tumor necrosis factor-alpha] in the *presence* or absence of . Positive_regulation TNF HES3 19910630 2189362 HK-2 cells were stimulated with [TNF-alpha] in the *presence* or absence of 130/0.42 or 200/0.5 . Positive_regulation TNF HES3 19910630 2189369 TNF-alpha stimulation resulted in a significant decrease of viability by 53 % -63 % , whereas viability decreased by only 32 % -40 % in coincubation with HES 130/0.42 ( P < 0.005 ) and remained even less affected by [TNF-alpha] in the *presence* of 200/0.5 ( P < 0.001 ) . Positive_regulation TNF HES3 23245375 2711188 improved liver microcirculation , cardiac index and DO ( 2 ) -I , but significantly *increased* IL-1ß , IL-6 and [TNF-a] levels and resulted in a mortality rate of 33 % . Positive_regulation TNF HES4 18434912 1900280 Glass capillaries were coated internally with either purified adhesion molecules or HUVEC , which were treated with [tumor necrosis factor-alpha] in the *presence* or absence of . Positive_regulation TNF HES4 19910630 2189361 HK-2 cells were stimulated with [TNF-alpha] in the *presence* or absence of 130/0.42 or 200/0.5 . Positive_regulation TNF HES4 19910630 2189368 TNF-alpha stimulation resulted in a significant decrease of viability by 53 % -63 % , whereas viability decreased by only 32 % -40 % in coincubation with HES 130/0.42 ( P < 0.005 ) and remained even less affected by [TNF-alpha] in the *presence* of 200/0.5 ( P < 0.001 ) . Positive_regulation TNF HES4 23245375 2711187 improved liver microcirculation , cardiac index and DO ( 2 ) -I , but significantly *increased* IL-1ß , IL-6 and [TNF-a] levels and resulted in a mortality rate of 33 % . Positive_regulation TNF HES5 18434912 1900279 Glass capillaries were coated internally with either purified adhesion molecules or HUVEC , which were treated with [tumor necrosis factor-alpha] in the *presence* or absence of . Positive_regulation TNF HES5 19910630 2189360 HK-2 cells were stimulated with [TNF-alpha] in the *presence* or absence of 130/0.42 or 200/0.5 . Positive_regulation TNF HES5 19910630 2189367 TNF-alpha stimulation resulted in a significant decrease of viability by 53 % -63 % , whereas viability decreased by only 32 % -40 % in coincubation with HES 130/0.42 ( P < 0.005 ) and remained even less affected by [TNF-alpha] in the *presence* of 200/0.5 ( P < 0.001 ) . Positive_regulation TNF HES5 23245375 2711186 improved liver microcirculation , cardiac index and DO ( 2 ) -I , but significantly *increased* IL-1ß , IL-6 and [TNF-a] levels and resulted in a mortality rate of 33 % . Positive_regulation TNF HES6 18434912 1900278 Glass capillaries were coated internally with either purified adhesion molecules or HUVEC , which were treated with [tumor necrosis factor-alpha] in the *presence* or absence of . Positive_regulation TNF HES6 19910630 2189359 HK-2 cells were stimulated with [TNF-alpha] in the *presence* or absence of 130/0.42 or 200/0.5 . Positive_regulation TNF HES6 19910630 2189366 TNF-alpha stimulation resulted in a significant decrease of viability by 53 % -63 % , whereas viability decreased by only 32 % -40 % in coincubation with HES 130/0.42 ( P < 0.005 ) and remained even less affected by [TNF-alpha] in the *presence* of 200/0.5 ( P < 0.001 ) . Positive_regulation TNF HES6 23245375 2711185 improved liver microcirculation , cardiac index and DO ( 2 ) -I , but significantly *increased* IL-1ß , IL-6 and [TNF-a] levels and resulted in a mortality rate of 33 % . Positive_regulation TNF HES7 18434912 1900276 Glass capillaries were coated internally with either purified adhesion molecules or HUVEC , which were treated with [tumor necrosis factor-alpha] in the *presence* or absence of . Positive_regulation TNF HES7 19910630 2189357 HK-2 cells were stimulated with [TNF-alpha] in the *presence* or absence of 130/0.42 or 200/0.5 . Positive_regulation TNF HES7 19910630 2189364 TNF-alpha stimulation resulted in a significant decrease of viability by 53 % -63 % , whereas viability decreased by only 32 % -40 % in coincubation with HES 130/0.42 ( P < 0.005 ) and remained even less affected by [TNF-alpha] in the *presence* of 200/0.5 ( P < 0.001 ) . Positive_regulation TNF HES7 23245375 2711183 improved liver microcirculation , cardiac index and DO ( 2 ) -I , but significantly *increased* IL-1ß , IL-6 and [TNF-a] levels and resulted in a mortality rate of 33 % . Positive_regulation TNF HGF 10485595 644320 *increased* serum [TNF-alpha] on day 2 after burn , while it decreased serum IL-1beta on day 1 after burn compared with placebo ( P < 0.05 ) . Positive_regulation TNF HGF 10708191 673507 *increased* the hepatic gene expression of [tumor necrosis factor-alpha] compared with controls ( p < .05 ) . Positive_regulation TNF HGF 11152574 758998 As can be potential *targets* for [TNF-alpha] in inflamed gingiva , we hypothesized that HGF partially modulate the cellular responses to TNF-alpha by regulating their own TNFR . Positive_regulation TNF HGF 12445174 1017558 in MNP is not directly *induced* by interferon-alpha , interferon-gamma or [tumour necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF HGF 15541342 1336893 production is *induced* by the activation of protein kinase A and protein kinase C-mediated pathways , interleukin (IL)-1 , [tumor necrosis factor (TNF)-alpha] , and epidermal growth factor (EGF) in mesenchymal cells . Positive_regulation TNF HGF 15629451 1362285 Candidates of the factors are inflammatory cytokines released by polymorphonuclear and mononuclear cells infiltrating the wounded area , but production in human dermal fibroblasts is only slightly *induced* by interleukin (IL)-1 , [tumor necrosis factor (TNF)-alpha] or interferon (IFN)-gamma . Positive_regulation TNF HGF 21229279 2419644 Plasma levels of [tumor necrosis factor-a (TNF-a)] , interleukin 8 (IL-8) , interferon-? inducible protein-10 (IP-10) , monocyte chemotactic protein-1 (MCP-1) , soluble urokinase-type plasminogen activator ( suPAR ) , monokine *induced* by ?-interferon ( MIG ) , human , insulin , interleukin 6 (IL-6) , interleukin 1-ß (IL-1ß) , leptin , and nerve growth factor (NGF) were analyzed . Positive_regulation TNF HGF 9367839 463413 Although HGF did not detectably influence the proliferation or morphology of HMC-1 cells , *inhibited* the cells ' ability to release [tumor necrosis factor-alpha (TNF-alpha)] in response to stimulation with PMA and the calcium ionophore , A23187 . Positive_regulation TNF HIF1A 12808024 1102187 In tubular LLC-PK1 or human embryonic kidney cells , [TNF-alpha] *induced* accumulation of protein but not HIF-1alpha mRNA . Positive_regulation TNF HIF1A 15925386 1440367 Our observations show that calcium , MAPK activation , , and NF-kappaB are *necessary* for ethanol induced [TNF-alpha] and TGF-beta1 expression . Positive_regulation TNF HIF1A 19766100 2147411 [TNFalpha] *induces* expression through activation of IKKbeta . Positive_regulation TNF HIST1H1B 1292694 207803 beta MDP , beta C16H33 MDP , P-MDP and MDP *induced* similar level of [TNF] production by murine macrophages . Positive_regulation TNF HIST2H2BE 19330264 2052603 *induced* the production of IL-12 p40 and [TNF-alpha] by peritoneal cells and IFN-gamma by spleen cells from germ-free or monoassociated Swiss/NIH mice and LPS-hyporesponsive mice ( around 40 ng/mL for IL-12 p40 , 200 pg/mL for TNF-alpha and 10 ng/mL for IFN-gamma ) . Positive_regulation TNF HK1 21368235 2404294 SP and trigger IL-1ß , IL-6 , and TNF-a production , upregulate IL-23 production , and *enhance* [TNF-like] 1A expression on monocyte surface . Positive_regulation TNF HLA-A 15944290 1416145 Human scFv-G8 ( POS ) T lymphocytes comprising the gamma + CD28 vs the gamma signaling element alone produced substantially more IL-2 , [TNF-alpha] , and IFN-gamma in *response* to ( POS ) melanoma cells . Positive_regulation TNF HLA-DRA 11914744 925313 [TNFalpha] alone did not *induce* expression , but enhanced IFN gamma induced MHC class II expression . Positive_regulation TNF HLA-DRA 11914744 925321 IFN gamma and [TNFalpha] synergistically *induced* expression on insulinoma cells through the induction of CIITA ; Positive_regulation TNF HLA-DRA 12067408 955019 CD34 expression was gradually lost , so that by day 9 , the majority of the cells were CD34 ( - ) /CMRF-44 ( + ) . GM-CSF and [TNF-alpha] also *induced* CD40 expression , and up-regulation of CD54 and on CD34 ( + ) cells ; Positive_regulation TNF HLA-DRA 16154304 1499436 Our results demonstrate that BM injected once ip in mice at 10 and 20 mg/kg increased the cellular influx to the peritoneal cavity , the expression and the spreading ability , and also *induced* the production of NO , [TNF] and H ( 2 ) O ( 2 ) . Positive_regulation TNF HLA-DRA 2005400 154737 Transcriptional *activation* of IL-1 beta and [tumor necrosis factor-alpha] genes by ligands . Positive_regulation TNF HLA-DRA 7499872 336118 Studies with a neutralizing anti-TNF-alpha Ab , however , indicate that LPS augmentation of did not *require* [TNF-alpha] . Positive_regulation TNF HLA-DRA 8898955 393181 Taken together , our data indicate that [TNF-alpha] expression is tightly *regulated* by ligands , both at the transcriptional and translational levels . Positive_regulation TNF HLA-DRB1 11914744 925314 [TNFalpha] alone did not *induce* expression , but enhanced IFN gamma induced MHC class II expression . Positive_regulation TNF HLA-DRB1 11914744 925322 IFN gamma and [TNFalpha] synergistically *induced* expression on insulinoma cells through the induction of CIITA ; Positive_regulation TNF HLA-DRB1 12067408 955020 CD34 expression was gradually lost , so that by day 9 , the majority of the cells were CD34 ( - ) /CMRF-44 ( + ) . GM-CSF and [TNF-alpha] also *induced* CD40 expression , and up-regulation of CD54 and on CD34 ( + ) cells ; Positive_regulation TNF HLA-DRB1 16154304 1499437 Our results demonstrate that BM injected once ip in mice at 10 and 20 mg/kg increased the cellular influx to the peritoneal cavity , the expression and the spreading ability , and also *induced* the production of NO , [TNF] and H ( 2 ) O ( 2 ) . Positive_regulation TNF HLA-DRB1 17646260 1829645 *Activation* of TNFR1 or by [TNF-alpha] or TRAIL may regulate osteoblast connectivity , which is important to bone turnover . Positive_regulation TNF HLA-DRB1 19349211 2088721 In vitro , expression of TRAIL , and DR5 on primary proximal tubular epithelial cells ( PTEC ) was *induced* by [TNFalpha] and IFNgamma . Positive_regulation TNF HLA-DRB1 2005400 154738 Transcriptional *activation* of IL-1 beta and [tumor necrosis factor-alpha] genes by ligands . Positive_regulation TNF HLA-DRB1 7499872 336119 Studies with a neutralizing anti-TNF-alpha Ab , however , indicate that LPS augmentation of did not *require* [TNF-alpha] . Positive_regulation TNF HLA-DRB1 8898955 393182 Taken together , our data indicate that [TNF-alpha] expression is tightly *regulated* by ligands , both at the transcriptional and translational levels . Positive_regulation TNF HLA-DRB1 9563466 500649 [TNF-alpha] , a nongenotoxic cytokine , also *induced* the expression of in a number of cancer cell lines , irrespective of p53 status . Positive_regulation TNF HMGB1 10975801 729380 In the present studies , given intratracheally produced acute inflammatory injury to the lungs , with neutrophil accumulation , the development of lung edema , and *increased* pulmonary production of IL-1beta , [TNF-alpha] , and macrophage-inflammatory protein-2 . Positive_regulation TNF HMGB1 12687539 1078779 SFMs expressed RAGE and released [TNFalpha] , interleukin-1beta (IL-1beta) , and IL-6 upon *stimulation* with . Positive_regulation TNF HMGB1 15584967 1345506 Interestingly , the *induced* [TNF-alpha] release from monocytes could be inhibited by either the A-box of the protein or the p38 inhibitor CNI-1493 , but neither had any inhibitory effects on the HMGB1 dependent upregulation of cell-adhesion molecules on HUVEC . Positive_regulation TNF HMGB1 15644117 1363528 *induced* [TNF] and NO production by Mphi , phosphorylation of all investigated MAP kinase pathways and NF-kappaB translocation , and expression of MHC class II was increased . Positive_regulation TNF HMGB1 15673164 1350791 Native and recombinant *induced* [TNF-alpha] release in human blood and in THP-1 cells dose-dependently , but recombinant HMGB1s were more effective . Positive_regulation TNF HMGB1 16635351 1552722 [ Effect of inhibitors of signal transducer and activator of transcription-1/3 on expression of [tumor necrosis factor-alpha] *induced* by protein inflammatory response in rat peritoneal macrophages ] . Positive_regulation TNF HMGB1 16635351 1552723 ( 2 ) could *induce* [TNF-alpha] release in rat peritoneal macrophages , with peaking at 4 hours and decreasing at 8 hours later . Positive_regulation TNF HMGB1 16635351 1552729 STAT1 and STAT3 might be involved in the regulation of TNF-alpha gene expression , but not in [TNF-alpha] early release ( < 24 hours ) *induced* by stimulation in rat peritoneal macrophages . Positive_regulation TNF HMGB1 16878026 1593772 Similarly , in primary human macrophages , *induced* [TNF] release is dose-dependently inhibited by anti-TLR4 antibodies . Positive_regulation TNF HMGB1 16878026 1593773 In primary macrophages from knockout mice , *activates* significantly less [TNF] release in cells obtained from MyD88 and TLR4 knockout mice as compared with cells from TLR2 knockout and wild-type controls . Positive_regulation TNF HMGB1 17172981 1679428 Secondly , the role of JAK/STAT pathway in the regulation of [TNF-alpha] expression *induced* by was examined . Positive_regulation TNF HMGB1 17430886 1748899 Both full-length and a truncated form of HMGB1 lacking the highly conserved glutamate-rich C-terminal tail can *induce* macrophage activation and [tumor necrosis factor-alpha] production . Positive_regulation TNF HMGB1 17548579 1784246 Loss of *leads* to a defect in the IL-6 , IL-12 , [TNFalpha] , and iNOS response to CpG-ODN . Positive_regulation TNF HMGB1 17697615 1782246 In the present study , the investigators explored the clinical significance of alteration in the serum levels of HMGB1 in childhood acute lymphocytic leukemia ( ALL ) and the mechanism of *induced* [tumor necrosis factor (TNF)-alpha] secretion in leukemic cells . Positive_regulation TNF HMGB1 17697615 1782263 The effects of inhibitors specific for the MAPK on *induced* [TNF-alpha] secretion were assayed by using ELISA . Positive_regulation TNF HMGB1 17697615 1782266 Inhibitors specific for the JNK ( SP600125 ) , MEK ( PD98059 ) , and p38 MAPK ( SB203580 ) , abrogated *induced* [TNF-alpha] secretion . Positive_regulation TNF HMGB1 17895302 1802741 can *induce* expression of [TNF-alpha] and IL-1beta , and formation of a pro-inflammatory loop between HMGB1 , TNF-alpha , and IL-1beta may be responsible for the prolonged and sustained inflammation in CLE . Positive_regulation TNF HMGB1 17948903 1889004 Extracellular *enhances* the expression of RANKL , [TNFalpha] , and IL6 in osteoblastogenic bone marrow stromal cell cultures , and it is chemotactic to osteoclasts . Positive_regulation TNF HMGB1 18354232 1887634 protein binding to lipopolysaccharide facilitates transfer of lipopolysaccharide to CD14 and *enhances* lipopolysaccharide mediated [TNF-alpha] production in human monocytes . Positive_regulation TNF HMGB1 18953944 1982601 [TNFalpha] *induces* the release and cytoplasmic translocation of in the peripheral blood monocytes of RA patients and thalidomide inhibits the release and translocation of HMGB1 . Positive_regulation TNF HMGB1 20163887 2333685 activates nuclear factor-?B signaling by RAGE and *increases* the production of [TNF-a] in human umbilical vein endothelial cells . Positive_regulation TNF HMGB1 20547845 2284902 Here we show that Toll-like receptor 4 (TLR4) , a pivotal receptor for activation of innate immunity and cytokine release , is required for *dependent* activation of macrophage [TNF] release . Positive_regulation TNF HMGB1 20618136 2286560 Our data show that A/TMD1 significantly inhibits *induced* [TNF-alpha] release and might be useful in treating HMGB1 elevated sepsis . Positive_regulation TNF HMGB1 21186276 2396758 However , inhibition of *attenuated* myocyte [TNF-a] production after the A/R was challenged ; Positive_regulation TNF HMGB1 21186276 2396759 surprisingly , itself did not *induce* myocyte [TNF-a] production . Positive_regulation TNF HMGB1 21406085 2404546 In HepG2 cell culture , LPS or [TNF] actively *induced* cytoplasmic translocation and release in a time- and dose dependent fashion . Positive_regulation TNF HMGB1 22065079 2540529 and Nalp3 induce proinflammatory responses and *lead* to interleukin-1ß and [TNF-a] secretion and NF-?B activity , thereby promoting cell survival and tumor growth . Positive_regulation TNF HMGB1 22139321 2585554 Interestingly , the *induced* nuclear factor kappa B activation and [tumor necrosis factor-alpha] release from HUVECs were inhibited by lower concentration thrombin . Positive_regulation TNF HMGB1 23146691 2729592 EG was found to suppress the release of HMGB1 , the production of [tumor necrosis factor (TNF)-a] , and the *activation* of nuclear factor-?B ( NF-?B ) by in HUVECs , and to inhibit HMGB1 mediated hyperpermeability and leukocyte migration in mice . Positive_regulation TNF HMGB1 23209806 2705554 As a result , HMGB1 in vitro upregulated expressions of [TNF-a] and IL-1ß of KCs in a dose dependent manner , and *promoted* KCs from burn rats to produce significantly more TNF-a and IL-1ß proteins than those from sham animals . Positive_regulation TNF HMGB1 24012904 2862288 We examined the effect of histamine on *induced* expression of ICAM-1 , B7.1 , B7.2 and CD40 on monocytes , production of IFN-? and [TNF-a] and lymphocyte proliferation in PBMCs . Positive_regulation TNF HMGB1 24152910 2875278 It was found that thrombin down-regulates the mediated *induction* of both [TNF-a] and IL-6 and inhibits the activation of both p38 MAPK and NF-?B in HUVECs pretreated with PC . Positive_regulation TNF HMGB1 24184598 2889903 In addition , GCLs suppressed the production of [tumor necrosis factor-a] and interleukin 6 and *activation* of nuclear factor-?B and extracellular regulated kinases 1/2 by . Positive_regulation TNF HMGCR 14630701 1188068 As shown by ELISA and FACS analyses , inhibitors ( e.g. , lovastatin ) *impair* the [TNF-alpha] stimulated increase in E-selectin protein expression . Positive_regulation TNF HMGCR 17172275 1717247 Simvastatin , a <3-hydroxy-3-methylglutaryl-CoA reductase> inhibitor , which is known to activate PI3K/Akt , *blocks* [TNF-alpha-] and insulin induced PAI-1 expression . Positive_regulation TNF HMHA1 9012541 405324 *had* no effect on either [TNF alpha] or elastase release . Positive_regulation TNF HMOX1 10330231 614320 [TNF-alpha] and IL-1alpha *induce* via protein kinase C , Ca2+ , and phospholipase A2 in endothelial cells . Positive_regulation TNF HMOX1 15319486 1303764 These results show that DEP , through eDEP mediated ROS , *induce* expression and IL-10 production and at the same time inhibit AM production of [TNF-alpha] and IL-12 to dampen the host immune responses . Positive_regulation TNF HMOX1 16822952 1625235 [TNF-alpha] did not *induce* expression in CMVEC . Positive_regulation TNF HMOX1 16888021 1596829 , a stress-inducible protein , also *regulates* IL-10 and [TNF-alpha] production . Positive_regulation TNF HMOX1 18981090 1983356 Additionally , overexpression of NQO1 and/or *inhibited* LPS induced [TNF] and IL-1beta expression . Positive_regulation TNF HMOX1 19122175 2037072 The finding that LSS dependent reduction of [TNF-alpha] generation and *induction* were abrogated by the selective inhibitor of COX-2 NS-398 , the nonselective COX inhibitor aspirin , or the specific prostacyclin receptor ( IP ) antagonist RO3244794 illuminates the central role played by LSS induced COX-2 dependent prostacyclin in restraining endothelial inflammation . Positive_regulation TNF HMOX1 20052772 2232479 Inhibition of activity , either by treatment with the HO-1 inhibitor zinc protoporphyrin or by siRNA knockdown of HO-1 , *prevented* the inhibitory effect of gAcrp on LPS stimulated [TNF-alpha] expression in Kupffer cells . Positive_regulation TNF HMOX1 22155307 2531177 induction significantly reduced the expression of matrix metalloproteinase (MMP)-1 , MMP-2 and MMP-3 , and the production of pro-inflammatory cytokines such as [tumor necrosis factor-a] and IL-6 whereas IL-10 levels *increased* . Positive_regulation TNF HMOX1 23423194 2755341 *Role* of in [TNF/TNF] receptor mediated apoptosis after hepatic ischemia/reperfusion in rats . Positive_regulation TNF HNRNPD 11116146 786590 NF-kappaB activation by the [tumor necrosis factor receptor (TNFR)] *involves* the formation of a termed a signalosome . Positive_regulation TNF HNRNPF 10861035 705049 The ligation of as well as Con A blasts by IL-12 *induced* the production of GM-CSF , IL-1beta , IL-6 , [TNF-alpha] , and IFN-gamma at the transcription levels . Positive_regulation TNF HNRNPF 11035052 740861 Contrasting with our previous report using cultured splenic DCs , freshly isolated splenic killed YAC-1 cells using a Ca ( 2+ ) -independent mechanism , but this function did not appear *mediated* by Fas ligand , TNF related apoptosis inducing ligand , or [TNF-alpha] . Positive_regulation TNF HNRNPF 12871639 1112531 The absence of *results* in profound [TNF] and iNOS deficiencies and an inability to clear primary bacterial infection . Positive_regulation TNF HNRNPF 16317102 1532933 CD40L expressing L929 cells *induced* to produce interleukin-6 (IL-6) , [tumor necrosis factor-alpha (TNF-alpha)] , and IL-12 , which was strongly inhibited by coexpression of SLAM on the surface of the L929 cells . Positive_regulation TNF HNRNPF 16622206 1551611 In addition , Campylobacter infected triggered activation of NF-kappaB and significantly *stimulated* production of interleukin-1beta (IL-1beta) , IL-6 , IL-8 , IL-10 , IL-12 , gamma interferon , and [tumor necrosis factor alpha (TNF-alpha)] compared to uninfected DCs . Positive_regulation TNF HNRNPF 17296788 1698839 We show that dyslipidemia inhibited Toll-like receptor (TLR) induced production of proinflammatory cytokines , including interleukin (IL)-12 , IL-6 , and [tumor necrosis factor-alpha] , as well as *up-regulation* of costimulatory molecules by CD8alpha ( - ) , but not by CD8alpha ( + ) DCs , in vivo . Positive_regulation TNF HNRNPF 17512567 1761982 After LPS stimulation , IL-6 , IL-10 , IL-12 ( p70 ) , and [TNF-alpha] levels significantly *increased* with both and DCs , but Pb-DCs produced significantly less cytokines than did DCs , except for IL-10 , which further supports Pb-DC preferential skewing toward type-2 immunity . Positive_regulation TNF HNRNPF 18180802 1883480 The results show that the T-HSP70 is capable of maturing human *inducing* an increase in the expression level of the CD83 , CD86 and human leukocyte antigen-DR surface markers , as well as in the secretion of interleukin (IL)-12 , [tumor necrosis factor-alpha (TNF-alpha)] and IL-6 cytokines . Positive_regulation TNF HNRNPF 19285436 2051514 Overexpression of c-Fos suppressed LPS induced cytokine production , whereas cAMP mediated suppression of [TNF-alpha] and IL-12 was *impaired* in Fos ( -/- ) or in RAW264.7 cells treated with c-Fos siRNA . Positive_regulation TNF HNRNPF 20089703 2206075 The stimulation of cLP with fractalkine/CX(3)CL1 *increased* the release of IL-6 and [TNF-alpha] . Positive_regulation TNF HNRNPF 20386470 2245234 LPS stimulation of *induced* IL-10 , IL-12p70 , [TNFalpha] and IL-1beta secretion , and taxol pretreatment modified this response by down regulating IL-1beta secretion whereas colchicine induced a proinflammatory cytokine profile with reduced IL-10 and increased IL-12p70 and TNFalpha secretion . Positive_regulation TNF HNRNPF 20735407 2341635 Shikonin treated were poor stimulators of CD4 ( + ) T lymphocyte and *induced* lower levels of interleukin (IL)-4 , IL-5 , IL-13 and [tumour necrosis factor (TNF)-a] release by responding T-cells . Positive_regulation TNF HNRNPF 22132887 2530426 Interaction of pulsed with CA9-AbOmpA fusion proteins with naive T cells *stimulated* secretion of IL-2 , interferon ( IFN ) -? and [tumour necrosis factor (TNF)-a] in T cells . Positive_regulation TNF HNRNPF 22310548 2552443 EIEC triggered to produce interleukin (IL)-10 , IL-12 and tumour necrosis factor (TNF)-a , whereas S. flexneri *induced* only the production of [TNF-a] . Positive_regulation TNF HNRNPF 22486596 2606865 Here , we show that parasite GPIs efficiently activate through TLR2 mediated signalling mechanism and *induce* the production of [TNF-a] and IL-12 . Positive_regulation TNF HNRNPF 22611024 2691427 In rats with Bact-DNA in MLNs without GBT , intestinal and MLNs CD103 ( + ) <-DCs> showed features of activation , expansion of the proinflammatory CD4 ( + ) -DC subpopulation , *augmented* [TNF-a] production , and increased phagocytic and migratory capacities . Positive_regulation TNF HNRNPF 7561684 324224 These can be expanded for several weeks by in vitro culture with c-kit-ligand , and their differentiation *requires* exogenous [TNF-alpha] in addition to GM-CSF . Positive_regulation TNF HNRNPH1 10861035 705050 The ligation of as well as Con A blasts by IL-12 *induced* the production of GM-CSF , IL-1beta , IL-6 , [TNF-alpha] , and IFN-gamma at the transcription levels . Positive_regulation TNF HNRNPH1 11035052 740862 Contrasting with our previous report using cultured splenic DCs , freshly isolated splenic killed YAC-1 cells using a Ca ( 2+ ) -independent mechanism , but this function did not appear *mediated* by Fas ligand , TNF related apoptosis inducing ligand , or [TNF-alpha] . Positive_regulation TNF HNRNPH1 12871639 1112532 The absence of *results* in profound [TNF] and iNOS deficiencies and an inability to clear primary bacterial infection . Positive_regulation TNF HNRNPH1 16317102 1532934 CD40L expressing L929 cells *induced* to produce interleukin-6 (IL-6) , [tumor necrosis factor-alpha (TNF-alpha)] , and IL-12 , which was strongly inhibited by coexpression of SLAM on the surface of the L929 cells . Positive_regulation TNF HNRNPH1 16622206 1551612 In addition , Campylobacter infected triggered activation of NF-kappaB and significantly *stimulated* production of interleukin-1beta (IL-1beta) , IL-6 , IL-8 , IL-10 , IL-12 , gamma interferon , and [tumor necrosis factor alpha (TNF-alpha)] compared to uninfected DCs . Positive_regulation TNF HNRNPH1 17296788 1698840 We show that dyslipidemia inhibited Toll-like receptor (TLR) induced production of proinflammatory cytokines , including interleukin (IL)-12 , IL-6 , and [tumor necrosis factor-alpha] , as well as *up-regulation* of costimulatory molecules by CD8alpha ( - ) DCs , but not by CD8alpha ( + ) , in vivo . Positive_regulation TNF HNRNPH1 17512567 1761983 After LPS stimulation , IL-6 , IL-10 , IL-12 ( p70 ) , and [TNF-alpha] levels significantly *increased* with both Pb-DCs and , but Pb-DCs produced significantly less cytokines than did DCs , except for IL-10 , which further supports Pb-DC preferential skewing toward type-2 immunity . Positive_regulation TNF HNRNPH1 18180802 1883481 The results show that the T-HSP70 is capable of maturing human inducing an *increase* in the expression level of the CD83 , CD86 and human leukocyte antigen-DR surface markers , as well as in the secretion of interleukin (IL)-12 , [tumor necrosis factor-alpha (TNF-alpha)] and IL-6 cytokines . Positive_regulation TNF HNRNPH1 19285436 2051515 Overexpression of c-Fos suppressed LPS induced cytokine production , whereas cAMP mediated suppression of [TNF-alpha] and IL-12 was *impaired* in Fos ( -/- ) or in RAW264.7 cells treated with c-Fos siRNA . Positive_regulation TNF HNRNPH1 20089703 2206076 The stimulation of cLP with fractalkine/CX(3)CL1 *increased* the release of IL-6 and [TNF-alpha] . Positive_regulation TNF HNRNPH1 20386470 2245235 LPS stimulation of *induced* IL-10 , IL-12p70 , [TNFalpha] and IL-1beta secretion , and taxol pretreatment modified this response by down regulating IL-1beta secretion whereas colchicine induced a proinflammatory cytokine profile with reduced IL-10 and increased IL-12p70 and TNFalpha secretion . Positive_regulation TNF HNRNPH1 20735407 2341636 Shikonin treated were poor stimulators of CD4 ( + ) T lymphocyte and *induced* lower levels of interleukin (IL)-4 , IL-5 , IL-13 and [tumour necrosis factor (TNF)-a] release by responding T-cells . Positive_regulation TNF HNRNPH1 22132887 2530427 Interaction of pulsed with CA9-AbOmpA fusion proteins with naive T cells *stimulated* secretion of IL-2 , interferon ( IFN ) -? and [tumour necrosis factor (TNF)-a] in T cells . Positive_regulation TNF HNRNPH1 22207023 2549739 This is the first study , which reports the *role* of PDIA3 and in [TNF-a] production in DENV infected cells . Positive_regulation TNF HNRNPH1 22310548 2552444 EIEC triggered to produce interleukin (IL)-10 , IL-12 and tumour necrosis factor (TNF)-a , whereas S. flexneri *induced* only the production of [TNF-a] . Positive_regulation TNF HNRNPH1 22486596 2606866 Here , we show that parasite GPIs efficiently activate through TLR2 mediated signalling mechanism and *induce* the production of [TNF-a] and IL-12 . Positive_regulation TNF HNRNPH1 22611024 2691428 In rats with Bact-DNA in MLNs without GBT , intestinal and MLNs CD103 ( + ) <-DCs> showed features of activation , expansion of the proinflammatory CD4 ( + ) -DC subpopulation , *augmented* [TNF-a] production , and increased phagocytic and migratory capacities . Positive_regulation TNF HNRNPH1 7561684 324225 These can be expanded for several weeks by in vitro culture with c-kit-ligand , and their differentiation *requires* exogenous [TNF-alpha] in addition to GM-CSF . Positive_regulation TNF HNRNPK 24751651 2936606 Silencing of does not affect TAK1 mRNA synthesis or stability but enhances TAK1 mRNA translation , *resulting* in elevated [TNF-a] , IL-1ß , and IL-10 mRNA expression . Positive_regulation TNF HNRNPU 22345668 2572022 Knockdown of hnRNP U expression greatly attenuated TLR induced expression of TNF-a , IL-6 , and IL-1ß , but not IL-12 , whereas overexpression greatly *increased* TLR induced expression of [TNF-a] , IL-6 , and IL-1ß . Positive_regulation TNF HP 18849391 2021360 Diet samples , feed refusals , feces , and urine were collected daily for 5 d. Rectal temperature and serum concentrations of cortisol , prolactin , [tumor necrosis factor-alpha] , and *increased* , whereas thyroxine and triiodothyronine decreased for +LPS vs. -LPS steers ( LPS x h ; Positive_regulation TNF HP 2460085 98224 Human recombinant tumour necrosis factor ( [cachectin] ) *induced* a dose dependent increase in synthesis of and ceruloplasmin . Positive_regulation TNF HPD 17289434 1698418 Before virulent challenge , BCG vaccination clearly enhanced the ability of BALC , PC and SPC to produce [TNF-alpha] in *response* to stimulation ex vivo . Positive_regulation TNF HPD 3606157 75765 In the present study , we achieved a partial response of a metastatic lesion in a patient with renal cancer by the *induction* of endogenous [TNF] by and OK-432 ( a streptococcal preparation ) . Positive_regulation TNF HPD 8425210 210954 *induced* [TNF] production was much weaker and was not significantly changed during this observation time . Positive_regulation TNF HRAS 17059425 1683920 Zoledronate reduced Ras prenylation , and RhoA translocation to the membrane , and sustained ERK1/2 phosphorylation and [tumor necrosis factor (TNF)] *induced* JNK phosphorylation . Positive_regulation TNF HRAS 17994109 1851137 [TNF-alpha] triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* , p38 MAPK , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation TNF HSF1 15198852 1260537 This raised the question of how [TNF-alpha] transcription could occur at all in the *presence* of activated . Positive_regulation TNF HSF1 18689673 1973616 Heat shock proteins ( hsps ) and the ( HSF-1 ) induced by oxidative stress *regulate* NF-kappaB activation and [TNF-alpha] gene expression in monocytes and macrophages . Positive_regulation TNF HSF1 24196691 2891632 Microgravity activated may *contribute* to the decreased [TNF-a] expression in macrophages directly caused by microgravity , while the LPS induced NF-?B pathway is resistant to microgravity . Positive_regulation TNF HSF2 18689673 1973617 Heat shock proteins ( hsps ) and the ( HSF-1 ) induced by oxidative stress *regulate* NF-kappaB activation and [TNF-alpha] gene expression in monocytes and macrophages . Positive_regulation TNF HSF4 18689673 1973618 Heat shock proteins ( hsps ) and the ( HSF-1 ) induced by oxidative stress *regulate* NF-kappaB activation and [TNF-alpha] gene expression in monocytes and macrophages . Positive_regulation TNF HSF5 18689673 1973615 Heat shock proteins ( hsps ) and the ( HSF-1 ) induced by oxidative stress *regulate* NF-kappaB activation and [TNF-alpha] gene expression in monocytes and macrophages . Positive_regulation TNF HSP90AA1 15020249 1221500 [TNFalpha] *induces* rapid activation and nuclear translocation of in human lymphocytes . Positive_regulation TNF HSP90AA1 15326480 1296850 The present study described that , in the leukemic KG1 cells , [TNFalpha] *induced* no apoptosis but a senescence state characterized by prolonged growth arrest , increased beta-galactosidase activity , p21WAF-1 induction , decreased activity , telomeric disturbances ( shortening , losses , fusions ) , and additional chromosomal aberrations . Positive_regulation TNF HSP90AB1 18689673 1973641 Further , *regulates* [TNF-alpha] production in macrophages contributing to alcohol induced inflammation . Positive_regulation TNF HSPA14 21730052 2471486 In this study , we found that binds directly to TLR4 on the surface of DCs , activates MAPK and NF-?B pathways , up-regulates I-a ( b ) , CD40 , CD80 , and CD86 expression and *promotes* production of [TNF-a] , IL-1ß , and IL-12p70 . Positive_regulation TNF HSPA5 15077298 1233071 Although *stimulated* the early production of [tumor necrosis factor alpha (TNF alpha)] , the major cytokine induced was IL-10 . Positive_regulation TNF HSPA8 10867521 706484 We suggest that the increased expression of MC during peritonitis is in part *induced* by [TNF-alpha] and IL-1beta and may exert a cell-protective function , lessening MC damage during peritonitis . Positive_regulation TNF HSPB1 11034403 740721 Exaggerated human monocyte IL-10 concomitant to minimal [TNF-alpha] *induction* by suggests Hsp27 is primarily an antiinflammatory stimulus . Positive_regulation TNF HSPB1 11421614 830841 does not *induce* secretion of [TNF-alpha] , IL-10 , or IL-12 , whereas LPS does signal IL-12 and TNF-alpha secretion . Positive_regulation TNF HSPB1 18486623 1927777 [TNF] stimulation *induced* p38 MAPK dependent phosphorylation of MK2 and . Positive_regulation TNF HSPB1 7673331 325939 [Tumor necrosis factor-alpha] *induces* changes in the phosphorylation , cellular localization , and oligomerization of human , a stress protein that confers cellular resistance to this cytokine . Positive_regulation TNF HSPB3 16916598 1672915 *Induction* of high-molecular-weight ( HMW ) [tumor necrosis factor(TNF) alpha] by hepatitis C virus ( HCV ) non-structural ( NS3 ) in liver cells is AP-1 and NF-kappaB dependent activation . Positive_regulation TNF HSPB3 19165919 2007037 The TNFAIP3 ( [tumor necrosis factor] alpha *induced* ) gene encodes a ubiquitin editing enzyme , A20 , that restricts NF-kappaB dependent signaling and prevents inflammation . Positive_regulation TNF HSPB3 21762402 2472182 Exposed monocytes released interleukin-10 but not [tumor necrosis factor-a] in *response* to , suggesting the possible involvement of secreted female proteins in host immune responses . Positive_regulation TNF HSPB8 18381796 1892927 In contrast , both LPS and *resulted* in significantly lower secretion of IL-6 , [TNF-alpha] , and IL-10 in those who carried the variant , whereas the frequency of CD14+ cells was higher in these individuals . Positive_regulation TNF HSPD1 12686536 1099844 Recent studies have shown that commercially available recombinant human ( rhHSP60 ) could *induce* [tumor necrosis factor alpha (TNF-alpha)] release from macrophages and monocytes in a manner similar to that of lipopolysaccharide (LPS) , e.g. via CD14 and Toll-like receptor 4 complex mediated signal transduction pathway . Positive_regulation TNF HSPD1 14688078 1190335 Moreover , *increased* the level of [tumor necrosis factor alpha (TNF-alpha)] in culture medium in a dose dependent manner . Positive_regulation TNF HSPD1 15371451 1334335 The induction of [tumor necrosis factor-alpha] secretion in mouse macrophages is lost after endotoxin removal and is not *mediated* by expressed in eukaryotic systems . Positive_regulation TNF HSPD1 16481340 1534753 We found that a murine anti-HSP60 mAb enhanced the production of IL-8 and [tumor necrosis factor-alpha] *induced* by human in the human monocytic cell lines THP-1 and U937 , and human peripheral blood monocytes . Positive_regulation TNF HSPD1 22326972 2612360 Recombinant Wolbachia ( rWmhsp60 ) *induces* gene expression of pro-inflammatory cytokines IL-1ß , IL-6 and [TNF-a] in human monocytic cell line THP-1 . Positive_regulation TNF HSPD1 9711934 527008 Both C pneumoniae and recombinant chlamydial *induced* [TNF-alpha] production by mouse macrophages in a concentration- and time dependent fashion . Positive_regulation TNF HSPD1 9711934 527009 Chlamydial and human *induce* [TNF-alpha] and MMP production by macrophages . Positive_regulation TNF HSPG2 11854220 913515 Both LPS and *induced* high levels of [tumor necrosis factor alpha (TNF-alpha)] , interleukin 1 beta ( IL-1 beta-6 , gamma interferon ( IFN-gamma ) , MIP-1 alpha MIP-2 in the lungs but did not affect IL-18 levels . Positive_regulation TNF HSPG2 17158358 1716898 In this study we investigated the *role* of phosphatidylcholine-specific phospholipase C ( ) in silica stimulated induction of [TNF-alpha] and IL-1beta and how PC-PLC activity is regulated by silica in a rat alveolar macrophage model . Positive_regulation TNF HSPG2 17158358 1716902 We demonstrated that inhibition of , which was achieved with tricychodecan-9-yl-xanthate ( D609 ) , *blocked* the silica stimulated induction of [TNF-alpha] and IL-1beta in alveolar macrophage , suggesting that PC-PLC is involved in the silica associated inflammatory response . Positive_regulation TNF HSPG2 17947707 1814429 Furthermore , these ( 2+ ) inhibitors also *blocked* rhLIGHT mediated IkappaBalpha degradation , generation of reactive oxygen species , [TNF-alpha] production and the bactericidal activities of monocytes . Positive_regulation TNF HSPG2 8760826 378177 We have investigated the *role* of a TNF-responsive phosphatidylcholine-specific phospholipase C ( ) for the cytotoxic and proinflammatory activity of [TNF] . Positive_regulation TNF HSPG2 9414418 408182 HePC inhibited fMLP induced phosphatidylinositol-specific activation in HL60 cells and [TNF-alpha] *induced* activation of phosphatidylcholine-specific PLC in U937 cells . Positive_regulation TNF HTN3 15864435 1401345 [TNF-alpha] *induced* expression of , FUT3 , C2/4GnT and MUC5AC mRNAs in NCI-H292 cells . Positive_regulation TNF HTR1A 16938291 1615367 Treatment with CP 's alone indicated that agonistic effects on beta-2 adrenoceptors and antagonistic effects on alpha-2 , <5-HT1A> and 5-HT1D receptors *resulted* in statistically significant decreased [TNF-alpha] levels in comparison to the LPS-control group . Positive_regulation TNF HTR1D 16938291 1615368 Treatment with CP 's alone indicated that agonistic effects on beta-2 adrenoceptors and antagonistic effects on alpha-2 , 5-HT1A and <5-HT1D> receptors *resulted* in statistically significant decreased [TNF-alpha] levels in comparison to the LPS-control group . Positive_regulation TNF HTR2A 21248590 2380034 [TNF] *induced* <5-HT2A> receptor expressions in the DRG , while 5-HT induced TNF and TNF receptor 1 expressions . Positive_regulation TNF HUNK 11991968 938613 To determine the *role* of in the production of [TNF-alpha] , we focused on the function of its nonstructural protein , NS1 , and established monocytic U937 lines transduced with the NS1 gene under the control of an inducible promoter . Positive_regulation TNF IAPP 24222351 2932434 In cultured islets , macrophages ( F4/80 ( + ) CD11b ( + ) CD11c ( + ) cells ) were required for *induced* mRNA expression of the proinflammatory cytokines IL-1ß , [tumor necrosis factor-a] , and IL-6 and the anti-inflammatory cytokines IL-10 and IL-1 receptor antagonist . Positive_regulation TNF IARS 15956278 1452286 Moreover , the ligation of *induces* ( 1 ) production of [tumor necrosis factor alpha (TNF-alpha)] and interferon gamma (IFN-gamma) and ( 2 ) brisk cytolytic activity against cells bearing appropriate IRS counter-ligands . Positive_regulation TNF ICAM1 10219841 609115 These results indicate that IFN-gamma and [TNF-alpha] *induce* the expression of on parenchymal hepatocytes and that the LFA-1-ICAM-1 pathway plays an important role in the interaction between hepatocytes and neutrophils or lymphocytes . Positive_regulation TNF ICAM1 10395656 627479 Using rat astrocytes in culture , we report that binding by specific Abs *induces* [TNF-alpha] secretion together with phosphorylation of the transcription factor cAMP response element binding protein . Positive_regulation TNF ICAM1 10425270 632804 In contrast , the pro-inflammatory cytokine [TNFalpha] , whose activity is dependent on the generation of intracellular ROS , *induces* IL-8 and in both cell types . Positive_regulation TNF ICAM1 10430178 633558 [Tumor necrosis factor-alpha (TNF-alpha)] *induced* both VCAM-1 and expression in human umbilical vein endothelial cells ( HUVECs ; Positive_regulation TNF ICAM1 10491002 645875 [TNF-alpha] and IL-1 sequentially *induce* endothelial and VCAM-1 expression in MRL/lpr lupus-prone mice . Positive_regulation TNF ICAM1 10807781 692330 [Tumor necrosis factor-alpha] *induced* the expression of VCAM-1 , E-selectin , and but had no effect on P-selectin expression . Positive_regulation TNF ICAM1 10821844 694650 We have previously shown that alpha-melanocyte stimulating hormone ( alpha-MSH ) can oppose [tumor necrosis factor] alpha *activation* of NF-kappaB ( 1-2 h ) and up-regulation ( mRNA by 3 h and protein by 24 h ) in melanocytes and melanoma cells . Positive_regulation TNF ICAM1 10996391 733871 Early production of [TNFalpha] after liver injury could *induce* an increased and a decreased PECAM-1 expression , which might be essential for the transmigration of inflammatory cells into the parenchyma . Positive_regulation TNF ICAM1 11154420 762897 Prostaglandins E2 and I2 downregulate [tumor necrosis factor] alpha *induced* expression in human oral gingival epithelial cells . Positive_regulation TNF ICAM1 11154420 762899 [TNF alpha] potently *induced* expression in a dose- and time dependent fashion . Positive_regulation TNF ICAM1 11490158 845650 These results suggest that increased expression of ICAM-1 by endothelial cells might be involved in the pathogenesis of acute KD , and that [TNF-alpha] might *induce* expression . Positive_regulation TNF ICAM1 11510784 848799 An upregulation of ( ICAM-1 ) expression was *induced* by [tumour necrosis factor-alpha (TNF-alpha)] ( p=0.0004 ) , but not by interleukin-4 (IL-4) ( p > 0.05 ) , while none of the two cytokines were able to increase hyaluronic-cellular adhesion molecule ( H-CAM ) expression by lung fibroblasts ( p > 0.05 ) . Positive_regulation TNF ICAM1 11763385 887884 Moreover , [TNF-alpha] *induced* expression of CD54 by cells in the medium , but not by those retained in the sheets , whereas human SCF induced , dose dependently , expression of by cells in the sheets , but not from those in the medium . Positive_regulation TNF ICAM1 12037401 949215 [TNF-alpha] *induced* an upregulation of expression ( p < 0.05 ) , which was not seen in fibroblasts cultured in the presence of IL-4 or bFGF . Positive_regulation TNF ICAM1 12067408 955021 CD34 expression was gradually lost , so that by day 9 , the majority of the cells were CD34 ( - ) /CMRF-44 ( + ) . GM-CSF and [TNF-alpha] also *induced* CD40 expression , and up-regulation of and MHC class II on CD34 ( + ) cells ; Positive_regulation TNF ICAM1 12124212 965694 Because IL-18 is a proinflammatory cytokine known to mediate the production of [TNF-alpha] and IL-1beta and to *induce* the expression of ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) , we hypothesized that neutralization of IL-18 would attenuate lipopolysaccharide (LPS) induced cardiac dysfunction . Positive_regulation TNF ICAM1 12213456 985382 Hydroxy- and acetoxyxanthones showed potent inhibitory effects on NADPH catalysed lipid peroxidation and [TNF-alpha] *induced* expression of on endothelial cells . Positive_regulation TNF ICAM1 12420742 1013420 Without NH2Cl , [TNF-alpha] *induced* marked expression of e-selectin and . Positive_regulation TNF ICAM1 12587980 1029761 [TNFalpha] *induced* VCAM-1 and expression and Jurkat T cell binding . Positive_regulation TNF ICAM1 12714560 1093384 We observed that [TNF-alpha] stimulation of endothelial cells *induced* PKCzeta activation and its association with . Positive_regulation TNF ICAM1 1346374 179111 IL-1 , IL-6 , [tumour necrosis factor-alpha (TNF-alpha)] and IFN-alpha , used alone or in combination , did not *induce* expression , neither did they inhibit the IFN-gamma induced expression of this adhesion molecule on HepG2 cells . Positive_regulation TNF ICAM1 1352532 190362 [TNF-alpha] alone *induced* only . Positive_regulation TNF ICAM1 1356158 197974 Among the molecules involved in antigen independent interactions between T lymphocytes and target cells , lymphocyte function associated molecule-3 ( LFA-3 ) was spontaneously expressed by most cultured human astrocytes , whereas ( ICAM-1 ) was present at variable levels in non stimulated astrocytes and was greatly *induced* by IFN-gamma , [TNF-alpha] , and IL-1 beta . Positive_regulation TNF ICAM1 1357985 200317 The ( ICAM-1 ) is *induced* on endothelial cells by [tumor necrosis factor-alpha (TNF-alpha)] , interleukin-1 beta (IL-1 beta) , and lipopolysaccharide (LPS) . Positive_regulation TNF ICAM1 1374096 186280 [TNF-alpha] also *induces* in both of these neural cell lines . Positive_regulation TNF ICAM1 14984317 1214671 The effect of high glucose concentration on [TNF-alpha] *induced* expression of ELAM-1 , VCAM-1 and was negligible , if at all . Positive_regulation TNF ICAM1 15113938 1241388 [TNF-alpha] significantly *induced* HUVEC protein expression of VCAM-1 , , and E-selectin with increasing mRNA levels . Positive_regulation TNF ICAM1 15625106 1362073 As in skin , [TNF] *induces* E-selectin and vascular cell adhesion molecule 1 only on venular ECs , whereas is up-regulated on all human ECs . Positive_regulation TNF ICAM1 15650392 1364026 [TNFalpha] , but not H2O2 , *induced* in A549 cells , which was attenuated by a proteasome inhibitor , but not by the p38 MAPK inhibitor SB203580 . Positive_regulation TNF ICAM1 15694007 1376335 Trogliazone ( 20 microM ) reduced [TNF-alpha] *induced* VCAM-1 , and E-selectin expression . Positive_regulation TNF ICAM1 16461740 1540829 Following Con A treatment , L-selectin deficiency reduced liver mRNA expression of [tumor necrosis factor-alpha] , and deficiency *reduced* expression of interleukin-4 . Positive_regulation TNF ICAM1 16529752 1671840 In HUVEC , [TNF-alpha] *induced* and VCAM-1 mRNA and surface expression . Positive_regulation TNF ICAM1 16595000 1568602 ICAM-1 : Part I of the study investigates in cytoflow studies the effect of abciximab ( 0.0002 , 0.002 , 0.02 , 0.2 , 2.0 , and 20.0 microg/ml ) on [TNF-alpha] *induced* expression of ( ICAM-1 ) . Positive_regulation TNF ICAM1 1670943 151260 IFN-gamma or [TNF-alpha] also *induced* on KC , but these KC failed to stimulate proliferation , suggesting that PMA induces additional signals from KC , which act in concert with ICAM-1 to promote proliferation . Positive_regulation TNF ICAM1 1673988 155032 Both IFN-gamma and [TNF] *induced* large increases in the expression on both cell lines and increased the susceptibility of the tumor cells to monocyte mediated killing . Positive_regulation TNF ICAM1 16983653 1666291 All the sample types *induced* a remarkable increase in [TNF-alpha] and IL-6 release in PBMC culture medium , while only the untreated sample and the nitrided at 10 hPa induced an increase in expression . Positive_regulation TNF ICAM1 17418379 1748711 was *induced* in human and guinea pig parasympathetic nerves by [TNF-alpha] and IFN-gamma and was inhibited by dexamethasone and by an inhibitor of nuclear factor-kappaB (NF-kappaB) . Positive_regulation TNF ICAM1 17498286 1744455 Part I of the study investigated in cytoflow studies the effect of SRL ( 0.01-1000 ng/ml ) on [TNF-alpha] *induced* expression of ( ICAM-1 ) in human coronary endothelial cells ( HCAEC ) and human coronary smooth muscle cells ( HCMSMC ) . Positive_regulation TNF ICAM1 17855547 1818135 To study the molecular basis of this down-regulation , the *induction* of [TNF-alpha] was analyzed in varicella-zoster virus ( VZV ) -infected melanoma cells ( MeWo ) , leading to the following observations : ( i ) VZV inhibits the stimulation of icam-1 mRNA synthesis; (ii) despite VZV induced nuclear translocation of p65 , p52 , and c-Rel , p50 does not translocate in response to TNF-alpha ; Positive_regulation TNF ICAM1 18292233 1885518 In organ culture , [TNF] *induced* expression of E-selectin , VCAM-1 , and on HUVECs but only ICAM-1 on HUAECs . Positive_regulation TNF ICAM1 18475445 209525 Since is not constitutively expressed on normal human articular cartilage , but could be *induced* in vitro by exogenous IL-1alpha , [TNFalpha] and IFNgamma or by co-culturing cartilage with inflammatory rheumatoid synovium , we conclude that the induction of ICAM-1 on rheumatoid chondrocytes results from the synergistic action of a variety of cytokines produced by the inflammatory cells of the invading pannus . Positive_regulation TNF ICAM1 18656701 1942657 [TNF-alpha] could significantly *induce* CCL2 , and VCAM-1 expression of PTEC . Positive_regulation TNF ICAM1 19384869 2069204 Stimulation of BM CD20 ( + ) B cells by CpG containing oligodeoxynucleotide enhanced expression of activation markers ( CD86 and ) *triggered* IL-6 and [TNF-alpha] secretion and cell proliferation . Positive_regulation TNF ICAM1 19674910 2126169 Inhibitory effect of beta-diketones and their metal complexes on [TNF-alpha] *induced* expression of on human endothelial cells . Positive_regulation TNF ICAM1 1982501 149817 [Tumor necrosis factor (TNF)] *induced* expression on ICAM-1- tumor cells , and simultaneously increased target cell susceptibility to MHC unrestricted as well as to anti-CD16 mAb triggered lysis . Positive_regulation TNF ICAM1 20045926 2192891 We investigated the effects of deoxypodophyllotoxin (DPT) on [tumor necrosis factor-alpha (TNF-alpha)] *induced* expression in the mouse lung epithelial cell line , LA4 . Positive_regulation TNF ICAM1 20657842 2293425 [TNF-alpha] *induced* a robust activation of MMP-9 , , and the IL-8 promoter driven reporter in Thy-1- MEFs , in contrast to only a modest increase in Thy-1+ counterparts . Positive_regulation TNF ICAM1 22465119 2583188 Finally , [TNF-a] potently *induced* and VCAM-1 expression in both SV-EC and SV-SMC . Positive_regulation TNF ICAM1 23049757 2684884 [TNF-alpha] *induced* expression was significantly inhibited by ( R ) -albuterol in a dose dependent manner , but not by ( S ) or ( R , S ) -albuterol . Positive_regulation TNF ICAM1 23299081 2737871 Both IFN-a and IFN-ß strongly reduced the production of IL-12p40 , IL-1ß and [TNF] and the IFN-? *induced* and CD64 expression . Positive_regulation TNF ICAM1 23751820 2895583 These results demonstrated that IFN-? and [TNF-a] *induced* expression through a common pathway that was regulated by autophagy , but not p53 . Positive_regulation TNF ICAM1 2497153 109737 [TNF] also *induced* keratinocyte expression ( although to a lesser degree than IFN-gamma ) but did not induce either keratinocyte HLA-DR or DQ expression . Positive_regulation TNF ICAM1 7491985 332386 In conclusion , 1 ) CD11a , , and CINC play major roles in the LPS initiated emigration of PMNs into the bronchoalveolar space , and 2 ) the [TNF] that drives ICAM-1 and CINC expression is *derived* largely from alveolar macrophages rather than PMNs . Positive_regulation TNF ICAM1 7511974 250202 [TNF-alpha] alone *induced* only HLA class I and , but not HLA class II or LFA-1 alpha . Positive_regulation TNF ICAM1 7536438 297254 [TNF-alpha] *induced* endothelial E-selectin , ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) in all groups , and adhesion molecule expression by interstitial dermal dendritic cells ( ICAM-1 and VCAM-1 ) and keratinocytes ( ICAM-1 ) was observed . Positive_regulation TNF ICAM1 7616001 315199 We propose that in EM suprabasal expression may be *induced* directly by HSV infection or indirectly through [TNF-alpha] release induced by HSV reactivation . Positive_regulation TNF ICAM1 7616001 315200 Suprabasal can be *induced* by UVR and epidermal [TNF-alpha] release , and by factors such as viral infection . Positive_regulation TNF ICAM1 7642556 317981 In contrast , [TNF alpha] *induced* transcription via activation of promoter sequences between -393 and -176 , a region with C/EBP and NF-kappa B binding sites . Positive_regulation TNF ICAM1 7685152 219706 In both rat pulmonary artery endothelial cells and human umbilical vein endothelial cells , [TNF alpha] *induced* an early ( within 60 minutes ) increase in expression , followed by a peak at 6 to 8 hours , with relatively stable expression at 24 hours . Positive_regulation TNF ICAM1 7906155 240345 [TNF alpha] or IL-1 treatment of HUVE potently *induced* surface expression , whereas these cytokines were relatively ineffective on HLE and HSE ICAM-1 expression . Positive_regulation TNF ICAM1 7915999 269783 IL-1 beta and [TNF-alpha] *induced* a parallel increase of both the expression on EC and sICAM-1 production by EC , while IFN-gamma induced only the dose dependent enhancement of ICAM-1 expression , but not the production of sICAM-1 , IL-4 and IL-6 did not show any effects on the ICAM-1 expression nor on the sICAM-1 production . Positive_regulation TNF ICAM1 7955542 277808 [TNF-alpha] significantly *induced* expression on these cells . Positive_regulation TNF ICAM1 7957928 278116 Synergistic *activation* of ( ICAM-1 ) by [TNF-alpha] and IFN-gamma is mediated by p65/p50 and p65/c-Rel and interferon-responsive factor Stat1 alpha ( p91 ) that can be activated by both IFN-gamma and IFN-alpha . Positive_regulation TNF ICAM1 8097205 214641 The expression of in myocardial cells could be *induced* in vitro by IFN-gamma and [TNF-alpha] , which were shown to be synthesized by the infiltrating cells . Positive_regulation TNF ICAM1 8214008 231541 Both interferon-gamma and [tumor necrosis factor-alpha] *induced* the ( CD54 ) in the cytoplasm and on the surface of nearly all myotubes . Positive_regulation TNF ICAM1 8702532 375476 [TNF-alpha] reduced the amount of syndecan-1 protein in EA.hy 926 cells in both the presence and absence of serum and , at the same time , *induced* the expression of ( ICAM-1 ) . Positive_regulation TNF ICAM1 8713799 376649 In this cell line [TNF alpha] *induced* the simultaneous appearance of stress fibers and of , which was clustered predominantly on endothelial cell projections . Positive_regulation TNF ICAM1 8796130 381273 These results suggest that the monocyte-endothelial cell interaction *induces* the expression of and VCAM-1 in endothelial cells partially through the production of IL-1 and [TNF] . Positive_regulation TNF ICAM1 8861747 388553 THD is capable of changing the density of [tumor necrosis factor alpha (TNFalpha)] *induced* ( CD54 ) , VCAM-1 ( CD106 ) and E-selectin antigens on HUVEC . Positive_regulation TNF ICAM1 8879188 390698 These results showed that [TNF alpha] and IFN gamma *induce* expression and infiltration of neutrophils in the lung . Positive_regulation TNF ICAM1 8880099 390762 expression was *induced* by [tumour necrosis factor-alpha (TNF-alpha)] in 1 of the 5 SCLC lines ( National Cancer Institute ( NCI ) H211 ) , and upregulated in 2 of the 5 NSCLC lines ( NCI H460 and NCI H838 ) . Positive_regulation TNF ICAM1 9039974 415837 This evidence contrasts with previously reported findings indicating that , in human cultured keratinocytes , expression is *induced* by IFN-gamma and [TNF-alpha] , and not by either IL-1 or LPS . Positive_regulation TNF ICAM1 9082943 420923 These data suggest that class II MHC antigens and on fibroblasts and endothelial cells are *induced* by IFN gamma and [TNF alpha] in an early stage of SSc after the influx of mononuclear-cells , and may be important in the putative autoimmune response and in the perpetuation of fibrotic processes in SSc . Positive_regulation TNF ICAM1 9105426 423484 Role of tyrosine kinase enzymes in [TNF-alpha] and IL-1 *induced* expression of and VCAM-1 on human umbilical vein endothelial cells . Positive_regulation TNF ICAM1 9187938 437073 One of the well-known physiological substances that induce the PAI-1 gene is [tumor necrosis factor-alpha] , which also *induces* other possible risk factors of atherosclerosis , ( ICAM-1 ) and vascular cell adhesion molecule-1 . Positive_regulation TNF ICAM1 9247582 446495 [TNF-alpha] *induced* expression in the keratinocytes from normal and TNFR2 ( - ) mice , but not in those from TNFR1 ( - ) mice . Positive_regulation TNF ICAM1 9407069 470796 Northern blot analysis revealed that [TNFalpha] *induced* both and IL-8 expression in either the A549 lung epithelial cell line or the human microvessel endothelial cell line ( HMEC-1 ) . Positive_regulation TNF ICAM1 9409229 471381 In cultured human smooth muscle cells from coronary arteries and saphenous veins , [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 beta (IL-1 beta) *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of . Positive_regulation TNF ICAM1 9430492 482108 Although IL-1 did not support GM-CSF induced eosinophil transendothelial migration , IL-1 and [TNF-alpha] *induced* equivalent expression of on HUVEC . Positive_regulation TNF ICAM1 9486918 488469 In addition , [TNFalpha] *induced* expression in one further case . Positive_regulation TNF ICAM1 9521860 493850 [TNF-alpha] and 9-cis-retinoic acid synergistically *induce* expression : evidence for interaction of retinoid receptors with NF-kappa B . Positive_regulation TNF ICAM1 9538628 497751 [TNF-alpha] and IL-1 released from mononuclear cells *induced* the up-regulation of expression and this may be related to the immune pathogenesis of IgA nephropathy . Positive_regulation TNF ICAM1 9610617 508786 [TNF-alpha] and LPS also *induced* MCP-1 and gene expression . Positive_regulation TNF ICAM1 9718198 528149 [TNF-alpha] *increases* expression of IL-6 and genes through activation of NF-kappaB in osteoblast-like ROS17/2.8 cells . Positive_regulation TNF ICAM1 9820785 547937 IFN-gammaand [TNF-alpha] *induced* both dose- and time dependent increases in expression . Positive_regulation TNF ICAM1 9820785 547939 [TNF-alpha] ( 100 U ml-1 ) *induced* a consistent approximately 6.0-fold increase in expression . Positive_regulation TNF ICAM1 9830008 551265 Unlike H2O2 , the proinflammatory cytokine [TNFalpha] *induced* IL-8 and in both cell types . Positive_regulation TNF ICAM2 10427988 633072 In contrast , and ICAM-3 *induced* a much stronger secretion of the Th1 cytokine [TNF-alpha] compared to LFA-1/ICAM-1 induced co-stimulation , despite the lower proliferation rate . Positive_regulation TNF ICAM2 9409229 471382 In cultured human smooth muscle cells from coronary arteries and saphenous veins , [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 beta (IL-1 beta) *induced* the expression of ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation TNF ICAM3 10427988 633073 In contrast , ICAM-2 and *induced* a much stronger secretion of the Th1 cytokine [TNF-alpha] compared to LFA-1/ICAM-1 induced co-stimulation , despite the lower proliferation rate . Positive_regulation TNF ICAM3 9409229 471383 In cultured human smooth muscle cells from coronary arteries and saphenous veins , [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 beta (IL-1 beta) *induced* the expression of ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation TNF ICAM4 9409229 471384 In cultured human smooth muscle cells from coronary arteries and saphenous veins , [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 beta (IL-1 beta) *induced* the expression of ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation TNF ICAM5 9409229 471385 In cultured human smooth muscle cells from coronary arteries and saphenous veins , [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 beta (IL-1 beta) *induced* the expression of ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation TNF ICMT 15647276 1402291 Here , we have shown that *regulates* [TNF alpha] stimulation of Rac1 activity . Positive_regulation TNF ICOS 15368302 1294917 We show that , although blocking *resulted* in a decrease in [TNF-alpha] and the Th2 cytokines IL-4 and IL-5 and serum levels of total IgE , it did not affect the expulsion of the adult parasites . Positive_regulation TNF ICOS 17013990 1629314 strikingly *potentiated* secretion of IL-2 , IFN-gamma , IL-10 , and [TNF-alpha] , but not IL-4 , promoted by optimal stimulation of CD3+CD28 , and it was the key switching-factor of activation when cells received suboptimal stimulation of CD3+CD28 or stimulation of CD3 alone in the presence of exogenous IL-2 . Positive_regulation TNF ICOSLG 15864782 1426026 IL-1alpha and [TNF-alpha] *induced* in an NF-kappaB dependent manner on human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation TNF ICOSLG 16552709 1542088 [TNF-alpha] significantly *induced* and CD40 expression by A549 cells , but had no effect on B7-1 or B7-2 expression . Positive_regulation TNF ICOSLG 16552709 1542091 Monocyte derived [TNF-alpha] in combination with IFN-gamma and LPS markedly *induced* expression in A549 cells . Positive_regulation TNF IDO1 1548034 183783 induced an approx. two-fold *increase* in [TNF alpha] release , but had no effect on IL-1 beta release . Positive_regulation TNF IDS 10382080 624299 IL-6 and [TNF-alpha] levels were *increased* in the intrauterine cavity of postmenopausal women with an . Positive_regulation TNF IER3 11244505 792321 Here , we show that in HeLa cells [TNFalpha] *induces* expression of in an NF-kappaB dependent fashion . Positive_regulation TNF IER3 19923449 2171835 The lack of also *suppressed* [TNF-alpha] production in both macrophages and T cells , resulting in a high intralesional load of parasites and delayed healing of the lesion , both of which were reversed by TNF-alpha treatment . Positive_regulation TNF IFI44 11443053 833719 Finally , PD-98059 , a MAPK pathway inhibitor , *blocked* [TNF-alpha] upregulation by eNOS ( P = 0.02 ) . Positive_regulation TNF IFI44 11675405 873238 The increase in [TNF-alpha] was *attenuated* by both a inhibitor , PD098059 ( 10 ( -6 ) M ) , and a p38 inhibitor , SB203580 ( 10 ( -6 ) M ) , and AP-1 binding activity was inhibited by PD098059 . Positive_regulation TNF IFI44 11777983 899886 Furthermore , IL-17 , IL-1beta , and [TNF-alpha] *induced* a rapid activation of extracellular signal related kinase and p38 MAPKs , and specific MAPK inhibitors ( SB203580 , PD98059 , and U0216 ) significantly reduced IL-17- , IL-1beta- , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Positive_regulation TNF IFI44 12160518 971796 [TNF-alpha] downregulated ACE , which effect was probably *mediated* by both and p38 MAPK pathways . Positive_regulation TNF IFI44 15302094 1283830 Selective MAPK inhibitor could *reduce* the Pb- and LPS triggered [TNF-alpha] expression in U-373MG cells . Positive_regulation TNF IFI44 18207479 1876662 [TNFalpha] signaling *involves* PI-3-kinase (PI3K)/protein kinase B (PKB) , and MAP kinase (MAPK) which are important in NF-kappaB activation . Positive_regulation TNF IFI44 24441870 2922959 On the other hand , [TNF-a] could *induce* Akt and MAPK translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation TNF IFI44 9885438 558287 On the other hand , [TNF] selectively induced tyrosine phosphorylation of p42 , and PMA selectively *induced* that of and p42 . Positive_regulation TNF IFIT2 24014876 2841873 Also , LPS induced secretion of IL-6 and [TNF-a] by bone marrow derived macrophages ( BMDMs ) was significantly enhanced in the *presence* of . Positive_regulation TNF IFN1@ 14991436 1215461 The low virus titres within brains of resistant mice coincided with a very mild inflammation , low counts of infiltrating inflammatory cells , and lower and [TNFalpha] gene *induction* than in susceptible mice . Positive_regulation TNF IFNA1 1552742 184099 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Positive_regulation TNF IFNA1 1696166 137179 Both [TNF] and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , , or IFN-gamma . Positive_regulation TNF IFNA1 2503543 115225 Endotoxin induction of [tumor necrosis factor] is *enhanced* by acid-labile in acquired immunodeficiency syndrome . Positive_regulation TNF IFNA10 1552742 184100 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Positive_regulation TNF IFNA10 1696166 137180 Both [TNF] and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , , or IFN-gamma . Positive_regulation TNF IFNA10 2503543 115226 Endotoxin induction of [tumor necrosis factor] is *enhanced* by acid-labile in acquired immunodeficiency syndrome . Positive_regulation TNF IFNA13 1552742 184101 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Positive_regulation TNF IFNA13 1696166 137181 Both [TNF] and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , , or IFN-gamma . Positive_regulation TNF IFNA13 2503543 115227 Endotoxin induction of [tumor necrosis factor] is *enhanced* by acid-labile in acquired immunodeficiency syndrome . Positive_regulation TNF IFNA14 1552742 184102 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Positive_regulation TNF IFNA14 1696166 137182 Both [TNF] and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , , or IFN-gamma . Positive_regulation TNF IFNA14 2503543 115228 Endotoxin induction of [tumor necrosis factor] is *enhanced* by acid-labile in acquired immunodeficiency syndrome . Positive_regulation TNF IFNA16 1552742 184103 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Positive_regulation TNF IFNA16 1696166 137183 Both [TNF] and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , , or IFN-gamma . Positive_regulation TNF IFNA16 2503543 115229 Endotoxin induction of [tumor necrosis factor] is *enhanced* by acid-labile in acquired immunodeficiency syndrome . Positive_regulation TNF IFNA17 1552742 184104 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Positive_regulation TNF IFNA17 1696166 137184 Both [TNF] and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , , or IFN-gamma . Positive_regulation TNF IFNA17 2503543 115230 Endotoxin induction of [tumor necrosis factor] is *enhanced* by acid-labile in acquired immunodeficiency syndrome . Positive_regulation TNF IFNA2 10022737 590135 BCG and/or differentially *increased* IL-1beta , IL-6 , IL-8 , GM-CSF and [TNF-alpha] production in the bladder cancer cells . Positive_regulation TNF IFNA2 1552742 184105 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Positive_regulation TNF IFNA2 1696166 137185 Both [TNF] and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , , or IFN-gamma . Positive_regulation TNF IFNA2 2503543 115231 Endotoxin induction of [tumor necrosis factor] is *enhanced* by acid-labile in acquired immunodeficiency syndrome . Positive_regulation TNF IFNA2 9208877 441008 is a potent inhibitor in vitro of the induction of IL-1 and tumor necrosis factor by IL-1 and can *induce* high circulating levels of the anti-inflammatory soluble [tumor necrosis factor] receptor and IL-1 receptor antagonist in humans . Positive_regulation TNF IFNA21 1552742 184106 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Positive_regulation TNF IFNA21 1696166 137186 Both [TNF] and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , , or IFN-gamma . Positive_regulation TNF IFNA21 2503543 115232 Endotoxin induction of [tumor necrosis factor] is *enhanced* by acid-labile in acquired immunodeficiency syndrome . Positive_regulation TNF IFNA4 1552742 184107 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Positive_regulation TNF IFNA4 1696166 137187 Both [TNF] and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , , or IFN-gamma . Positive_regulation TNF IFNA4 2503543 115233 Endotoxin induction of [tumor necrosis factor] is *enhanced* by acid-labile in acquired immunodeficiency syndrome . Positive_regulation TNF IFNA5 1552742 184108 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Positive_regulation TNF IFNA5 1696166 137188 Both [TNF] and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , , or IFN-gamma . Positive_regulation TNF IFNA5 2503543 115234 Endotoxin induction of [tumor necrosis factor] is *enhanced* by acid-labile in acquired immunodeficiency syndrome . Positive_regulation TNF IFNA6 1552742 184109 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Positive_regulation TNF IFNA6 1696166 137189 Both [TNF] and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , , or IFN-gamma . Positive_regulation TNF IFNA6 2503543 115235 Endotoxin induction of [tumor necrosis factor] is *enhanced* by acid-labile in acquired immunodeficiency syndrome . Positive_regulation TNF IFNA7 1552742 184110 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Positive_regulation TNF IFNA7 1696166 137190 Both [TNF] and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , , or IFN-gamma . Positive_regulation TNF IFNA7 2503543 115236 Endotoxin induction of [tumor necrosis factor] is *enhanced* by acid-labile in acquired immunodeficiency syndrome . Positive_regulation TNF IFNA8 1552742 184111 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Positive_regulation TNF IFNA8 1696166 137191 Both [TNF] and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , , or IFN-gamma . Positive_regulation TNF IFNA8 2503543 115237 Endotoxin induction of [tumor necrosis factor] is *enhanced* by acid-labile in acquired immunodeficiency syndrome . Positive_regulation TNF IFNAR1 22429450 2618075 Unlike in WT group , deficiency *attenuated* OLT expression of [TNF-a] , IL-1ß , IL-6 , MCP-1 , CXCL-10 , ICAM-1 ; Positive_regulation TNF IFNB1 10371521 622007 After 1 year of therapy , *restored* the normal production of [TNFalpha] , whereas therapy did not restore IFNgamma secretion to control values . Positive_regulation TNF IFNB1 10563614 566694 *inhibited* the proliferation of established MBP-reactive T-cell clones , which correlated with enhanced production of anti-inflammatory interleukin (IL)-4 and IL-10 , and a decrease in [tumor necrosis factor alpha (TNF-alpha)] and IFN-gamma . Positive_regulation TNF IFNB1 11444907 834151 *inhibits* the ability of T lymphocytes to induce [TNF-alpha] and IL-1beta production in monocytes upon direct cell-cell contact . Positive_regulation TNF IFNB1 11880161 919261 , in vitro , *increases* MCP-1 , [TNFalpha] and IFNgamma spontaneous production in all patients . Positive_regulation TNF IFNB1 12537690 1034145 An exaggerated production of TNF-alpha has been reported in murine viral infections , in which mice become sensitized to low amounts of LPS and both interferon (IFN)-gamma and are *involved* in the macrophage induced release of [TNF-alpha] . Positive_regulation TNF IFNB1 1292634 207774 Since [TNF] also *induces* in these cells and the latter cytokine itself has the capacity to upregulate HLA class I expression , we investigated the role of autocrine IFN-beta in the induction of HLA-B7 by TNF . Positive_regulation TNF IFNB1 1330686 200204 Furthermore , by using antibodies specific to each type of receptor , we demonstrate that both [TNF] receptors are equally *inducible* by IFN-alpha , and IFN-gamma . Positive_regulation TNF IFNB1 16785566 1577164 Surprisingly , combined stimulation by OMPs and also markedly *enhanced* [TNF-alpha] release by murine AMphi . Positive_regulation TNF IFNB1 16785566 1577168 AMphi derived from STAT1-deficient mice did not demonstrate increased production of [TNF-alpha] in *response* to PCP plus . Positive_regulation TNF IFNB1 17172979 1679422 Vascular dysfunction induced by E. coli requires TLR4 but has no requirement for TLR2 , TLR1 , TLR6 , or [TNF] , and a partial but incomplete requirement of MyD88 and TIR domain containing adapter *inducing* . Positive_regulation TNF IFNB1 17905201 1819055 Although *enhanced* the production of [tumor necrosis factor (TNF)-alpha] , interleukin (IL)-1beta , and nitric oxide ( NO ) by activated microglia , these molecules did not directly induce neurotoxicity in cultured cortical neurons . Positive_regulation TNF IFNB1 1846503 151685 Antibodies against IFN beta block this synergism , implying a *role* of in the antiviral activity of [TNF] plus IFN gamma . Positive_regulation TNF IFNB1 1846503 151689 Our results are in accordance with the idea that [TNF] *induces* 1 and that both cytokines must be present in the culture medium to synergize with IFN gamma in order to inhibit HSV-1 replication . Positive_regulation TNF IFNB1 18523264 1922806 LPS- and *induced* [TNF-alpha] are suppressed in RIG-I-deficient mouse embryo fibroblasts ( rig ( -/ ) ( - ) ) . Positive_regulation TNF IFNB1 1979069 145129 In several cultures , also increased ICAM-1 expression and *enhanced* the increase induced by [TNF-alpha] . Positive_regulation TNF IFNB1 2108965 131111 IL-2 alone did not induce the expression of either gene while IFN gamma or *had* a modest inductive effect on IP-10 but no effect on [TNF alpha] expression . Positive_regulation TNF IFNB1 2167923 140246 We conclude that the [TNF-alpha] induction of antiviral activity and UCRP in cells is *dependent* upon the presence of constitutive low levels of in the responding cells . Positive_regulation TNF IFNB1 2437032 71022 Release of endogenous IFN and [tumor necrosis factor] by endotoxin was also dramatically *increased* by recombinant human , and their levels in the blood were closely correlated with the increase of body temperature . Positive_regulation TNF IFNB1 2474237 103988 [TNF] *induced* transcription of 2 in resistant variants , indicating that this cytokine does not contribute to the antiviral activity of TNF . Positive_regulation TNF IFNB1 2543288 112417 The in vitro antiviral activity of [tumor necrosis factor (TNF)] in WISH cells is *mediated* by induction . Positive_regulation TNF IFNB1 3020123 63234 In HeLa cells , IFN-alpha and *increased* [125I-TNF] binding , whereas in HT-29 cells these two IFN either slightly decreased or had no effect on 125I-TNF binding . Positive_regulation TNF IFNB1 8035808 265135 However , nuclear extracts from cells treated with [TNF] in the *presence* of gave rise to an additional band that appears to contain protein components from the NF-kappa B and NF-IL-6 families . Positive_regulation TNF IFNG 10203355 606168 [TNF-alpha] or LPS alone did not induce nitrite production , but with these compounds did *induce* nitrite production . Positive_regulation TNF IFNG 10207167 606794 In this study , we demonstrate that activated T cells from patients with XHIM produce markedly reduced levels of , fail to induce antigen presenting cells to synthesize IL-12 , and *induce* greatly reduced levels of [TNF-alpha] . Positive_regulation TNF IFNG 10227996 610543 These data show that STAT6 is required for the IL-4 mediated inhibition of the production of TNF-alpha and IL-12 stimulated by LPS alone , but that IL-4 also activates distinct , STAT6 independent mechanism(s) that inhibit the *mediated* enhancement of IL-12 and [TNF-alpha] production . Positive_regulation TNF IFNG 10329109 613019 DHA inhibits macrophage stimulated NO production in *response* to and [TNF-alpha] . Positive_regulation TNF IFNG 10332965 614907 IL-10 exerted inhibitory effects on both CD40 ligation induced and CD40 ligation plus *induced* [TNF-alpha] production by ST cells . Positive_regulation TNF IFNG 10374812 623134 The T helper 1-type cytokine *induced* TNF transcripts , but not [TNF] secretion , and suppressed LPS induced IL-10 mRNA and secretion by microglia . Positive_regulation TNF IFNG 10409230 629913 Stimulation of CD40 molecules on the surface of alveolar macrophages with 3LLSA-CD40L cells induced the production of nitric oxide , [tumor necrosis factor-alpha] , and interleukin-12 and the tumoricidal activity of alveolar macrophages in the *presence* of , which increased the surface expression of CD40 molecules on alveolar macrophages . Positive_regulation TNF IFNG 10435757 634445 significantly *increased* [TNF-alpha] release and cotinine significantly increased NO release . Positive_regulation TNF IFNG 10504438 648911 Both GM-CSF and [TNF-alpha] *induced* the migration of human Langerhans cells in vitro , whereas IL-1beta , IL-2 , IL-10 , IL-12 , and had no effect on Langerhans cell migration . Positive_regulation TNF IFNG 10510391 651143 can *promote* production of [TNF] and can synergize with this cytokine in its actions on responder cells . Positive_regulation TNF IFNG 10533055 562398 Our results demonstrate a potent neurotoxicity *mediated* by the cytokine combination in primary human neuron-astrocyte cultures and a crucial role for endogenous [TNFalpha] in mediating neurotoxicity in this system . Positive_regulation TNF IFNG 10534550 562755 The enhanced production of [TNF-alpha] by ibandronate treated PBMC in vitro *involves* stimulation of adherent monocytes by prior to LPS induced activation . Positive_regulation TNF IFNG 10548204 564844 Unstimulated HUVECs did not produce detectable amounts of TNF-alpha , but , IL-1beta , and LPS when added together *induced* [TNF-alpha] production of HUVECs in a time dependent manner . Positive_regulation TNF IFNG 10548204 564848 , IL-1beta , or LPS alone did not *induce* [TNF-alpha] production , whereas IFN-gamma and IL-1beta in combination were able to induce TNF-alpha production to some extent , and the production could be further increased with LPS . Positive_regulation TNF IFNG 10569696 568023 Both IL-4 and IL-13 significantly inhibited [TNF] *induced* IL-6 release ( P < 0.01 for both ) while augmenting the effect of ( P < 0.005 and P < 0.01 , respectively. ) . Positive_regulation TNF IFNG 10580119 569979 Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the *induced* release of NO and [TNFalpha] . Positive_regulation TNF IFNG 10601128 574169 [Tumor necrosis factor-alpha (TNF-alpha)] alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 MAPK , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas can induce only ERK . Positive_regulation TNF IFNG 10694272 671291 synergistically *enhanced* the [TNF-alpha-] and LPS induced RANTES expression , but had no effect on the IL-1beta induced RANTES expression . Positive_regulation TNF IFNG 10723061 579415 *augmented* the activation of CPP32 by [TNF-alpha] in HOG cells and O2A ( + ) oligodendrocyte precursor cells but had no effect on mature oligodendrocytes . Positive_regulation TNF IFNG 10836514 697954 Thus , in contrast to the results obtained in murine models but in accordance with those observed in other human models , the present study shows for the first time in human monocytic cells that T. gondii does not induce any TNF-alpha secretion and inhibits [TNF-alpha] production *induced* by . Positive_regulation TNF IFNG 10848831 701073 SigM5 constitutively secreted interleukin (IL)-2 , IL-8 , IL-10 , [tumour necrosis factor (TNF)-alpha] , ferritin , lysozyme , N-elastase and neopterin upon *stimulation* with . Positive_regulation TNF IFNG 10851483 407161 The presence of *enhanced* production of [tumor necrosis factor-alpha] by macrophages exposed to lower concentrations of JT3002 and induced the release of nitric oxide , a potent cytolytic molecule of activated macrophages . Positive_regulation TNF IFNG 11054092 745235 In contrast , preincubation of the cells with iron before PMA induction resulted in a decrease of the [TNF-alpha] secretion *induced* by , whereas the opposite was true after preincubation with desferrioxamine . Positive_regulation TNF IFNG 11090084 754445 Among recombinant cytokines , [TNF-alpha] *induced* high levels of CCR6 mRNA expression , whereas induced low levels . Positive_regulation TNF IFNG 11129658 760011 Because IL-12 and mycobacteria also released IFN-gamma from macrophages synergistically , and exogenous with mycobacteria *enhanced* [TNF-alpha] and NO release synergistically , we examined the role of endogenous IFN-gamma in IL-12/mycobacteria stimulated macrophage activation . Positive_regulation TNF IFNG 11137619 758820 Some of them , i.e. ( R ) -PMPA , ( S ) -PMPA , and PMEG , stimulate secretion of TNF-alpha and IL-10 in a concentration dependent manner , and enhance the *induced* secretion of [TNF-alpha] . Positive_regulation TNF IFNG 11157054 780707 Initial comparisons indicated that [tumor necrosis factor] alpha induction of epithelial intercellular adhesion molecule 1 *required* sequential induction of interleukin (IL)-12 ( p70 ) and , and unexpectedly localized IL-12 production to airway epithelial cells . Positive_regulation TNF IFNG 11257311 794438 Human ANP ( 99-126 ) and a specific p38 MAP kinase inhibitor SB203580 inhibited the *induced* [TNF-alpha] production in a dose dependent manner without affecting NO production . Positive_regulation TNF IFNG 11257311 794449 Allopurinol or acetovanillone did not inhibit the *induced* production of [TNF-alpha] or NO , suggesting little involvement of oxidative stress in this system . Positive_regulation TNF IFNG 11298122 801857 However all the DC irrespective of origin were able to produce [TNF-alpha] , IL-6 , low levels of IL-12 ( p70 ) and NO in *response* to LPS plus . Positive_regulation TNF IFNG 11298293 803090 The present study concerns the effects of TGF-beta on *induced* activation of murine macrophages with respect to induction of toxoplasmastatic activity , and production of [tumour necrosis factor (TNF)-alpha] , prostaglandin E2 ( PGE2 ) and reactive nitrogen intermediates ( RNI ) . Positive_regulation TNF IFNG 11404395 825491 RAW264.7 cells treated with DAG analogue 1-oleoyl-2-acetyl-sn-glycerol , in the *presence* of , produced [TNF-alpha] . Positive_regulation TNF IFNG 11485347 844879 In this study , we show that bromelain , a mixture of cysteine proteases , can enhance *mediated* nitric oxide and [TNFalpha] production by macrophages . Positive_regulation TNF IFNG 11678640 873679 [TNF-alpha] *induced* the expression of VCAM-1 on HUVEC and GEC , but not MvE , while induced VCAM-1 expression only on HUVEC . Positive_regulation TNF IFNG 11777537 899645 However , while merozoites plus *induced* [TNF-alpha] mRNA expression in MDM , NO was not produced . Positive_regulation TNF IFNG 11813247 907440 Zaprinast also enhanced NO production induced by LPS or IFN-gamma ( 100 U/ml ) , and in microglial cell cultures , but not in astrocyte cultures , zaprinast enhanced the basal and the *induced* production of the cytokines , [TNF-alpha] and IL-1beta , and of NO . Positive_regulation TNF IFNG 11830590 928985 These results indicate that *induced* [TNF-alpha] production and subsequent NF-kappaB activation are integral parts of the mechanism of IFN-gamma induced CD40 expression . Positive_regulation TNF IFNG 11856640 914381 Production of [tumor necrosis factor-alpha (TNF-alpha)] and other proinflammatory cytokines in RA is largely CD4 ( + ) T-cell dependent and mostly a *result* of secretion . Positive_regulation TNF IFNG 11927652 927112 Stimulation of DC with *increased* the release of interleukin (IL)-12 and [tumor necrosis factor-alpha] and inhibited the production of IL-10 . Positive_regulation TNF IFNG 11943316 928686 The objectives of this study were to determine interleukin (IL)-1 beta , IL-2 , IL-4 , IL-5 , IL-6 , IL-8 , IL-10 , and [tumor necrosis factor (TNF)-alpha] *induction* in bronchoalveolar lavage (BAL) of control horses and horses with heaves both during remission and exacerbation of the disease , and to determine the effect of therapy with inhaled fluticasone propionate on the cytokine profile of horses with heaves . Positive_regulation TNF IFNG 12114316 964023 [TNF-alpha] and OSM , only when applied together , increased ALP activities and in vitro calcification in HVSMCs in the *presence* of and 1,25 ( OH ) 2D3 . Positive_regulation TNF IFNG 12117933 964678 A blockade of LTB ( 4 ) or PAF receptors partially inhibited *induced* NO and [TNF-alpha] production but not parasite killing . Positive_regulation TNF IFNG 12193701 981428 Additionally , *induced* [TNF-alpha] secretion , as well as STAT-1alpha and NF-kappaB activation , are inhibited in the presence of SOCS-1 . Positive_regulation TNF IFNG 12193701 981433 We conclude that SOCS-1 inhibits cytokine induced CD40 expression by blocking IFN-gamma mediated STAT-1alpha activation , which also then results in suppression of *induced* [TNF-alpha] secretion and subsequent NF-kappaB activation . Positive_regulation TNF IFNG 12207333 983611 The fact that antibodies to IFN-gamma also inhibit AgICD suggests that the perforin plus granzyme independent and FaSL and/or [TNF-alpha] facilitated process of AgICD of T effector cells is tightly *regulated* by endogenous . Positive_regulation TNF IFNG 12210742 984103 We demonstrate that MUC1 expression in T47D breast cancer cells and normal human mammary epithelial cells ( HMEC ) is enhanced by [tumor necrosis factor-alpha (TNF-alpha)] in the *presence* of . Positive_regulation TNF IFNG 12244188 990591 Whereas [TNF-alpha] production was normally up-regulated in *response* to , IL-12 production and CD64 up-regulation were strongly reduced , and IFN-gamma mediated killing of the intracellular pathogens Salmonella typhimurium and T. gondii was completely abrogated in patient 's macrophages . Positive_regulation TNF IFNG 12354417 993577 further *enhanced* the [IL-4+TNF-alpha] or IL-13+TNF-alpha induced TARC production in the fibroblasts . Positive_regulation TNF IFNG 12396716 1008691 In both cell lines , [TNF-alpha] increased the expression of PLA(2) IVA and IVC , and *increased* the expression of PLA(2) IIA and IID . Positive_regulation TNF IFNG 12417884 1013126 [TNF- alpha] , IL-1 beta , and significantly *increased* HMVEC-L permeability . Positive_regulation TNF IFNG 12452842 1020587 Indeed , parallel studies with PMN of healthy donors showed that while and granulocyte/macrophage colony stimulating factor ( GM-CSF ) induced both , MHC class II and CD83 , [tumour necrosis factor (TNF)-alpha] selectively *induced* de novo synthesis of CD83 . Positive_regulation TNF IFNG 12508147 1038512 also *increased* LPS induced [tumor necrosis factor (TNF)-alpha] in BAL fluid . Positive_regulation TNF IFNG 12508147 1038513 LPS induced [TNF-alpha] and CINC mRNA expression in alveolar macrophages was *increased* by . Positive_regulation TNF IFNG 12517728 1028006 rhIFN-gamma significantly *enhanced* [TNF] production in both controls and in ileal Crohn 's disease patients , while rhIL-12 enhanced but not TNF production . Positive_regulation TNF IFNG 12525575 1048056 ( 100 U/ml ) not only *increased* the synthesis and release of NO and [TNF-alpha] from these cells but also induced indoleamine-2,3-dioxygenase , the rate limiting enzyme of TRP catabolism . Positive_regulation TNF IFNG 12537690 1034146 An exaggerated production of TNF-alpha has been reported in murine viral infections , in which mice become sensitized to low amounts of LPS and both and IFN-alpha/beta are *involved* in the macrophage induced release of [TNF-alpha] . Positive_regulation TNF IFNG 12637227 1068553 Lipopolysaccharide (LPS)- or *induced* [TNF-alpha] and IL-6 production by murine AMs were suppressed by DEP in a dose dependent manner ( P < .05 ) . Positive_regulation TNF IFNG 12659174 767472 In the *presence* of , both FPP fractions stimulated [TNF-alpha] secretion . Positive_regulation TNF IFNG 12818375 1103791 and ( b ) the cyclic GMP analogues , on the contrary , concentration-dependently diminished *induced* [TNF alpha] synthesis . Positive_regulation TNF IFNG 1310901 178690 *induced* [TNF-alpha] production in RAW 264.7 cells and this induction was regulated at the transcriptional level . Positive_regulation TNF IFNG 1310901 178692 did not *stimulate* [TNF-alpha] production in either WEHI-3 cells or peritoneal macrophages , although MHC class II antigen expression was induced . Positive_regulation TNF IFNG 1330686 200202 Our results indicate that *induces* [TNF] receptors on both myeloid ( e.g. HL-60 ) and epithelial cells ( e.g. HeLa ) . Positive_regulation TNF IFNG 1330686 200205 Furthermore , by using antibodies specific to each type of receptor , we demonstrate that both [TNF] receptors are equally *inducible* by IFN-alpha , IFN-beta and . Positive_regulation TNF IFNG 1353987 192651 IL-4 , IL-6 , GM-CSF and *had* no effect on [TNF-alpha] production by T cells activated via either pathway . Positive_regulation TNF IFNG 1356158 197975 Among the molecules involved in antigen independent interactions between T lymphocytes and target cells , lymphocyte function associated molecule-3 ( LFA-3 ) was spontaneously expressed by most cultured human astrocytes , whereas intercellular adhesion molecule-1 ( ICAM-1 ) was present at variable levels in non stimulated astrocytes and was greatly *induced* by , [TNF-alpha] , and IL-1 beta . Positive_regulation TNF IFNG 13678668 1140182 [TNFalpha] alone caused robust NO ( 2 ) ( - ) flux , while IL6 had a lesser effect and neither nor IL1beta was *active* when applied singly . Positive_regulation TNF IFNG 14568183 1155271 Allergina alone or Allergina plus recombinant ( rIFN-gamma ) *increased* the production of [tumor necrosis factor (TNF)-alpha] , but Allergina decreased the production of TNF-alpha on rIFN-gamma plus LPS stimulated macrophages . Positive_regulation TNF IFNG 1460280 206639 This study was undertaken to further elucidate the mechanisms underlying TNF-alpha gene expression in the astrocyte , and to determine the intracellular signaling pathways involved in and/or IFN-gamma/IL-1 beta *induction* of the [TNF-alpha] gene . Positive_regulation TNF IFNG 1460280 206641 Two protein kinase C ( PKC ) inhibitors , H7 and staurosporine , abrogate IFN-gamma/LPS- and beta *induced* [TNF-alpha] expression in a dose dependent manner . Positive_regulation TNF IFNG 1500186 193629 If an interval of 2 days of culture in medium alone separates the first and second 24-h LPS stimulations , *enhances* [TNF-alpha] release only when it is included during the second LPS exposure , indicating that , unlike the persistence of endotoxin tolerance , enhancement of TNF-alpha release by IFN-gamma is transient . Positive_regulation TNF IFNG 15100317 1239748 Additionally , *induced* class I MHC up-regulation and [TNF-] and IFN-gamma induced IL-15 expression by beta cells were inhibited by SOCS-1 , which correlated with suppressed 8.3 T cell proliferation in vitro . Positive_regulation TNF IFNG 15145607 1247719 In the present study , we demonstrate that sodium butyrate repressed *induced* expression of iNOS and [TNF-alpha] , but had little effect on LPS induced expression in BV2 murine microglial cells . Positive_regulation TNF IFNG 15207784 1261688 The analysis performed during and after PCI revealed that levels increased 15 min after stent implantation in both chronic and ACS patients and that [TNF-alpha] levels *increased* in chronic patients only compared to basal values . Positive_regulation TNF IFNG 15229242 1269001 Silencing of GalT-2 gene with the use of antisense oligonucleotides resulted in decreased *induced* iNOS , [TNF-alpha] , and IL-1beta gene expression . Positive_regulation TNF IFNG 15351034 1292531 These results suggested that [TNF-alpha] is involved in pathogenesis of gastritis induced by H. felis infection as IFN-gamma and that an interaction between TNF-alpha and might be *required* in pathogenesis of gastritis induced by Helicobacter infection . Positive_regulation TNF IFNG 1541908 180875 Amo phi s incubated with 10 ( 3 ) ng/ml LPS produced 50 times more TNF than RPm phi s and 5 times more than TGPm phi s , and LPS alone induced maximum TNF production by Am phi s. Stimulated cell supernatant or recombinant alone did not *induce* [TNF] production . Positive_regulation TNF IFNG 1541908 180877 However , both LPS and stimulated cell supernatant or recombinant *induced* maximum [TNF] production by RPm phi s and TGPm phi s. TGPm phi s showed greater sensitivity to LPS and stimulated cell supernatant or IFN-gamma with regard to TNF production than the other macrophage populations investigated . Positive_regulation TNF IFNG 15470059 1317912 Furthermore , pretreatment with CpG ODN enhanced the production of [TNF-alpha] , and type-1 cytokines , including IL-12 , IFN-gamma , and the IFN-gamma dependent ELR- CXC chemokines IFN-gamma-inducible protein-10 and monokine *induced* by in response to Klebsiella challenge , compared with control mice . Positive_regulation TNF IFNG 15479886 1319912 IL18 , IL1 beta , and [TNF alpha] did not *induce* M-CSF , GM-CSF , , or OPG production in PHA prestimulated T cells or RA synovial T cells . Positive_regulation TNF IFNG 1552742 184177 Hairy cell leukemia (HCL) cells produced [TNF alpha] in the absence of stimuli and this production was markedly *enhanced* by addition of IFN alpha or , to a lesser extent , by and IL4 . Positive_regulation TNF IFNG 15604419 1369075 In the *presence* of , [TNF-alpha] increased GTPCH I mRNA in a manner dependent on nuclear factor-kappaB (NF-kappaB) , as this effect was abrogated by overexpression of a dominant negative IkappaB construct . Positive_regulation TNF IFNG 15617735 1357573 Treatment of glial cells with IC51 , an ADKI , stimulated the extracellular adenosine release and reduced the *mediated* production of NO , and induction of iNOS and [TNF-alpha] gene expression . Positive_regulation TNF IFNG 15699106 1372390 Furthermore , pretreatment of murine macrophages with pamidronate before stimulation with IFN-gamma significantly augments *dependent* production of [TNF-alpha] . Positive_regulation TNF IFNG 15728492 1377303 Taken together our results suggest a model in which *induced* [TNF] activates NF-kappaB , which is required for full COX-2 expression . Positive_regulation TNF IFNG 15743002 1352201 *induced* [TNF] release , and co-culture with LPS 1.0 or 10.0 ng/mL was strongly synergistic . Positive_regulation TNF IFNG 15743002 1352203 CARD15 1007fs mutation was linked in a gene-dose dependent manner to low [TNF] release *induced* by ( P value for linear trend = 0.001 ) . Positive_regulation TNF IFNG 15790516 1386375 treatment alone did not *induce* unstimulated macrophages to produce [TNF-alpha] . Positive_regulation TNF IFNG 1588290 188477 *enhanced* the monocyte release of [TNF-alpha] by 3-7.5-fold ( agonist dependent ) when added to patient 's cells in vitro , and this could be suppressed by the in vitro addition of 10 micrograms/ml of thalidomide . Positive_regulation TNF IFNG 15948973 1421196 Beside its apoptosis inducing capacity in HaCaT cells , rIFN-gamma also induced autocrine production , and combined treatment with IFN-gamma and TNF-alpha *induced* autocrine [TNF-alpha] production . Positive_regulation TNF IFNG 15968243 1423747 *increased* [TNF-alpha] production by monocytes in patients ( 683 pg/mL ; range , 186-2705 pg/mL ; Positive_regulation TNF IFNG 16034129 1436426 We report that [TNF] in the *presence* of activates Cat B as well as a caspase death pathway in both HUVEC and human dermal microvascular endothelial cells , but only activates caspase mediated death in HeLa cells and human embryonic kidney (HEK)293 cells . Positive_regulation TNF IFNG 16054790 1473751 Inhibition of lipopolysaccharide and *induced* expression of inducible nitric oxide synthase and [tumor necrosis factor-alpha] by Lithospermi radix in mouse peritoneal macrophages . Positive_regulation TNF IFNG 1611281 191044 CK-M stimulated thioglycollate *induced* peritoneal macrophages to produce interleukin 1 (IL-1) and [tumor necrosis factor alpha (TNF-alpha)] at concentrations of 1-100 ng/ml , and it also induced IL-2 and as well as IL-6 production by splenocytes . Positive_regulation TNF IFNG 16133999 1353309 In this study , using mouse peritoneal macrophages , we have examined whether XF affects nitric oxide ( NO ) , [tumor necrosis factor (TNF)-alpha] , and interleukin (IL)-12p40 production *induced* by and lipopolysaccharide (LPS) . Positive_regulation TNF IFNG 1617321 191270 Levels of [TNF-alpha] transcripts *induced* by were maintained for at least 36 h , in contrast to lipopolysaccharide (LPS) stimulation which caused TNF-alpha mRNA levels to peak after 2 h and decline rapidly thereafter . Positive_regulation TNF IFNG 16177125 1458043 The anti-IFN-gamma IgG had in vitro biological activity on the *dependent* phosphorylation of STAT-1 as well as on the IFN-gamma dependent up-regulation of [TNF-alpha] and IL-12 . Positive_regulation TNF IFNG 16181054 1461878 did not significantly *augment* the release of [TNF-alpha] by these cells ( p > 0.05 ) . Positive_regulation TNF IFNG 16227784 1469938 Hz and sHz significantly increased LPS- and *induced* [TNF-alpha] protein and transcripts in PBMC from animals with late stage SIV infection ( i.e. , AIDS ) . Positive_regulation TNF IFNG 16272279 1479278 A selective role for the [TNF] p55 receptor in autocrine signaling *following* stimulation in experimental autoimmune uveoretinitis . Positive_regulation TNF IFNG 16343349 1493985 Further , this stimulation was also able to suppress microglial [TNF-alpha] and nitric oxide production *induced* either by or Abeta peptide challenge in the presence of CD40 ligation . Positive_regulation TNF IFNG 16387840 1527044 CD56+natural killer cells , CD56+T cells , and CD57+T cells ( NK-T cells ) , which age-dependently increased in PBMC , produced much larger amounts of after IL-12 priming than that of conventional CD56-CD57-T cells and also *induced* cocultured macrophages to produce [TNF] by subsequent LPS stimulation . Positive_regulation TNF IFNG 16436136 1516385 Either SCF or [TNF-alpha] could *induce* release from HMC-1 cells of interleukin (IL)-8 , monocyte chemoattractant protein (MCP)-1 , regulated upon activation normal T-cell expressed and secreted ( RANTES ) , and I-309 , while SCF and TNF-alpha induced release of macrophage inflammatory protein (MIP)-1beta and protein-10 (IP-10) , respectively . Positive_regulation TNF IFNG 16481547 1496128 Using a low-dose infection C57BL/6 mouse model , we have demonstrated that host defense requires immune mechanisms involving CD4 T cell mediated , [TNF-alpha-] , IL-12- , and dependent , macrophage *activation* . Positive_regulation TNF IFNG 16487246 1524843 added prior to infection of mouse peritoneal macrophages with IgA opsonized bacilli *resulted* in a synergistic increase of nitric oxide and [TNFalpha] production and a 2-3 fold decrease in bacterial counts . Positive_regulation TNF IFNG 16580738 1562455 NPCs ' gelatinase activities of MMP-2 and MMP-9 , as determined by zymography , were *increased* by [TNF-alpha] , and to a lesser extent by . Positive_regulation TNF IFNG 16776679 1573090 In addition IL-4 , , and IL-10 were elevated in SAC and VKC , while eotaxin and [TNF-alpha] were only *increased* in VKC . Positive_regulation TNF IFNG 16931033 1627259 The expression of interferon responsive factor (IRF)-1 , an IFN-gamma induced transcriptional activator critical to IDO regulation , is also enhanced synergistically in *response* to and [TNF-alpha] . Positive_regulation TNF IFNG 16949677 1615659 Stimulation of blood monocytes with the cytokine enhanced significantly the release of NO and TNF-alpha , but IFN-gamma did not significantly *enhance* the production of NO and [TNF-alpha] by milk macrophages from lactating cows . Positive_regulation TNF IFNG 1696166 137192 Both [TNF] and LT mRNA were minimally *induced* by IL-1 alpha , IL-3 , interferon (IFN)-alpha , or . Positive_regulation TNF IFNG 17015935 1629939 P. ginseng plus recombinant instead of P. ginseng alone significantly *increased* the production of the [tumour necrosis factor (TNF)-alpha] in the mouse peritoneal macrophages . Positive_regulation TNF IFNG 17035338 1674522 It is interesting that we found that *induced* [TNF-alpha] secretion , and the induction of iNOS expression by IFN-gamma was abolished in primary peritoneal macrophages from TNF-alpha-deficient (TNF-alpha-/-) mice or in RAW 264.7 cells treated with anti-TNF-alpha neutralizing antibodies . Positive_regulation TNF IFNG 17035338 1674545 Taken together , our data suggest that the [TNF-alpha] produced in *response* to is required for iNOS induction by activating NF-kappaB transcription factor . Positive_regulation TNF IFNG 17141756 1686954 We designed to investigate the inhibitory effect of isatin derivatives on *induced* expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins , production of prostaglandin E ( 2 ) ( PGE ( 2 ) ) , nitric oxide ( NO ) , [tumor necrosis factor] ( TNF-alpha ) , and their capacity to scavenge NO . Positive_regulation TNF IFNG 1714325 163479 Further , [TNF alpha] appears to *mediate* the biologic effect of either in growth stimulation or growth inhibition . Positive_regulation TNF IFNG 17161819 1678973 They inhibited the expression of iNOS , [TNF-alpha] , and IL-6 *induced* by , while they enhanced the expression of the anti-inflammatory cytokine , IL-10 . Positive_regulation TNF IFNG 17196665 1732433 Meanwhile , 24h after poly I:C injection , expression of TLR3 was markedly elevated within decidua basalis ( DB ) , and endometrial [TNF-alpha] *increased* 2.7-fold but remained unchanged in homogenized endometrium . Positive_regulation TNF IFNG 17210665 1695841 In addition , in vitro [tumor necrosis factor alpha (TNF-alpha)] production by alveolar macrophages stimulated with heat killed pneumococci was *enhanced* by , and TNF-alpha in turn could enhance production of KC by lung cells . Positive_regulation TNF IFNG 17237425 1690080 We additionally found that the effect of and its synergy with CD40L on mFPR2 expression in microglia was *mediated* in part by [TNF-alpha] . Positive_regulation TNF IFNG 17254388 1664374 Although *caused* the production of various cytokines , such as IL-2 , IL-4 , IL-6 and [TNF-alpha] in TH2.52 cells , LPS did not cause the production of such cytokines . Positive_regulation TNF IFNG 17273910 1834960 *Upregulation* of [TNF-alpha] production by and LPS in cultured canine keratinocytes : application to monosaccharides effects . Positive_regulation TNF IFNG 17273910 1834961 We show that in combination with LPS significantly *increases* [TNF-alpha] secretion by canine keratinocytes . Positive_regulation TNF IFNG 17328963 1726376 Human [TNF-alpha] *induced* the expression of IP-10 mRNA in porcine endothelial cells , while both human and human IL-1beta failed . Positive_regulation TNF IFNG 17349923 1708037 We therefore evaluated the effects of liposomes , which comprise both PS and PC ( PS/PC liposomes ) , on the microglial production of [tumor necrosis factor-alpha (TNF-alpha)] , nitric oxide ( NO ) , and superoxide ( *O ( 2 ) - ) *induced* by amyloid beta ( Abeta ) and . Positive_regulation TNF IFNG 17349923 1708038 Pretreatment of microglia with PS/PC liposomes considerably inhibited the [TNF-alpha] , NO and *O ( 2 ) - production *induced* by . Positive_regulation TNF IFNG 17457174 1730248 Interestingly , inhibition of in CpG treated animals *reduced* [TNF-alpha] ( P < 0.05 ) , IL-6 ( P < 0.05 ) , nitrite ( P < 0.05 ) , and intestinal permeability following hemorrhagic shock ( P < 0.05 ) and down-regulated expression of TLR4 . Positive_regulation TNF IFNG 17484771 1778185 LPS induced production of tumour necrosis factor-alpha (TNF-alpha) , interleukin-6 (IL-6) , IL-10 and protein-10 (IP-10); SA *induced* [TNF-alpha] , and IL-1beta production ; Positive_regulation TNF IFNG 17507688 1772752 IFN-gamma induced CD40 expression involves activation of STAT-1alpha as well as NF-kappaB activation through an autocrine response to *induced* [TNF-alpha] production . Positive_regulation TNF IFNG 17520688 1784058 Cultured human mesangial cells ( HMCs ) expressed C3 mRNA and protein , and levels were increased in *response* to and [TNF-alpha] . Positive_regulation TNF IFNG 17570767 1753763 Cytokine profiling performed at the same time showed a biased Th1-type immune response with significantly increased and [tumor necrosis factor-alpha] *stimulation* . Positive_regulation TNF IFNG 17900305 1824073 and LPS *augmented* cell surface expression of Fas , but not [tumour necrosis factor (TNF)] receptor 1 . Positive_regulation TNF IFNG 1791140 176098 However , stimulation of macrophages with did greatly *enhance* the surface expression of membrane bound [TNF-alpha] in cells from the DMN treated animals . Positive_regulation TNF IFNG 1796655 176324 It will focus on interleukin-1 (IL-1) , IL-1 *inhibitors* , [Tumor-Necrosis-Factor-alpha (TNF-alpha)] , TNF inhibitors , Interleukin-6 (IL-6) , colony stimulating factors (CSF's) , , growth factors , eicosanoids and prostaglandins , all of which are important in the effector phase of tissue destruction . Positive_regulation TNF IFNG 1845803 151491 The increase in expression of I-A beta and [TNF] , *induced* by , was blocked by naphthalenesulfonamide or phenothiazine ( trifluoperazine ) but was not affected by the addition of isoquinolinesulfonamide or sphingosine . Positive_regulation TNF IFNG 18504053 1945045 MALP-2 only failed to alter cytokine or chemokine levels , but was highly effective in combination with resulting in increased *levels* of [TNFalpha] , IL-12 ( p40 ) , RANTES , and IL-1alpha . Positive_regulation TNF IFNG 18719314 1955806 Cocaine self administered for 18 days *induced* a significant increase in spleen weight , plasma corticosterone levels , interleukin (IL)-10 , and [tumor necrosis factor-alpha] production , while concanavalin A-stimulated proliferation responses of peripheral blood T-lymphocytes and production by splenic lymphocytes were not altered . Positive_regulation TNF IFNG 18802049 1964478 *induced* [TNF-alpha] expression is regulated by interferon regulatory factors 1 and 8 in mouse macrophages . Positive_regulation TNF IFNG 18802049 1964483 In this study , we report that [TNF-alpha] production is *induced* by treatment in the murine macrophage cell line RAW 264.7 . Positive_regulation TNF IFNG 18802049 1964484 [TNF-alpha] mRNA levels are increased in cells treated with IFN-gamma in a time dependent manner and also *increased* human TNF-alpha promoter dependent transcription . Positive_regulation TNF IFNG 18802049 1964492 In summary , treatment *induces* [TNF-alpha] expression at transcriptional level requiring the coordinate action of IRF-1 and IRF-8 . Positive_regulation TNF IFNG 1902635 156086 The results showed that plus LPS can indeed *stimulate* [TNF] and IL-1 secretion by AM and PBM from patients with COPD . Positive_regulation TNF IFNG 1902846 156093 On the other hand , [TNF alpha] plus IFN gamma induced TEC HLA-DR expression on both types of thyroid xenografts at death , although IL-2 alone did not induce HLA-DR expression , and *induced* TEC significantly only on normal thyroid xenografts ( but not on Graves ' xenografts ) . Positive_regulation TNF IFNG 1904523 159357 *enhanced* [TNF] production in the presence or absence of lipopolysaccharide (LPS) , but suppressed IL-1 production by Kupffer cells . Positive_regulation TNF IFNG 1905642 161635 First , both and IL 4 as single agents and in combination were potent *inducers* of [TNF-alpha] production by M phi infected with L. major amastigotes . Positive_regulation TNF IFNG 1906383 161721 GM-CSF synergistically enhanced [TNF-alpha] secretion *induced* by but not by lipopolysaccharide . Positive_regulation TNF IFNG 1906383 161724 In contrast , IL-2 synergistically enhanced [TNF-alpha] secretion *induced* by . Positive_regulation TNF IFNG 19257980 2045256 IgG stimulation *induced* a significant TLR4 expression and [TNF-alpha] secretion in cultured microglial cells in a dose dependent manner , while was not detected in the same medium samples . Positive_regulation TNF IFNG 19291774 2086830 Both and TNFalpha are important in this injury process , but [TNFalpha] *acts* as an autocrine amplifier of Kupffer cell function , rather than as a direct effector of hepatocellular damage . Positive_regulation TNF IFNG 19301423 2086902 A cytometry bead assay showed that the secretion of interleukin (IL)-2 decreased significantly , whereas that of IL-4 , IL-10 , [tumor necrosis factor-alpha] , and *increased* . Positive_regulation TNF IFNG 19422681 2082752 GW 501516 decreased the *induced* up-regulation of [TNF-alpha] and iNOS in accord with the proposed anti-inflammatory effects of this PPAR-beta agonist . Positive_regulation TNF IFNG 19453755 2097014 The stronger induction of IL-12 and [TNF-alpha] in the *presence* of was also observed by trehalose 6,6'-dimycolate ( TDM ) extracted from BCG-Japan than by TDM from BCG-Connaught , which lacks the methoxymycolate residue . Positive_regulation TNF IFNG 19465163 2162448 Three parameters of macrophage activation were assessed during Taenia infection : *induced* production of IL-12 , [TNF-alpha] and nitric oxide ( NO ) in vitro ; Positive_regulation TNF IFNG 19465163 2162449 The maximum response to *induced* [TNF-alpha] , IL-12 and NO production by macrophages from both strains of mice occurred 2 wk post-infection . Positive_regulation TNF IFNG 19467635 2085305 We found that the flavanones naringenin and hesperetin and the flavanols ( + ) -catechin and ( - ) -epicatechin , but not the anthocyanidins cyanidin and pelargonidin , attenuated *induced* [TNF-alpha] production in glial cells . Positive_regulation TNF IFNG 19472212 2102251 These results suggest that [TNF-alpha] induces CXCL10 production by activating NF-kappaB through ERK and that *induces* CXCL10 production by increasing the activation of STAT1 through JAKs pathways . Positive_regulation TNF IFNG 19514423 2092700 Patients with highly active hepatitis and maximal morphological changes in the liver had significant lowering of NDV induced production of IFN-alpha , , TNF-alpha , IL-6 and PGA *induced* production of [TNF-alpha] . Positive_regulation TNF IFNG 1966932 152084 alone did not induce either cytokine , but in the presence of GM-CSF it *caused* a synergistic ( 100-fold ) increase in [TNF] but not IL-1 production . Positive_regulation TNF IFNG 19700144 2133272 Also , the presence of exogenous in the growth medium significantly *induced* IL-6 , but not IL-1beta or [TNF-alpha] , in D1 and D2 cells . Positive_regulation TNF IFNG 20637124 2304613 This M1-M2 switch was shown by a decreased expression of CD80 upon LPS/IFNgamma stimulation , an increased secretion of IL-10 , a decreased secretion of [TNFalpha] in *response* to and an inability to potentiate apoptosis . Positive_regulation TNF IFNG 20738198 2313463 All tachyzoite and antigen preparations at high doses stimulated high levels of interleukin (IL) -12 , , and tumor necrosis factor (TNF) -alpha , except for heat killed tachyzoites and sNcAg , which *induced* moderate level of IL-12 and very low levels of IFN-gamma and [TNF-alpha] . Positive_regulation TNF IFNG 2107144 128707 *induced* the production of [TNF] and the anti-toxoplasmic effect provided by IFN-gamma seemed to be dependent partly on the production of TNF . Positive_regulation TNF IFNG 2108965 131112 IL-2 alone did not induce the expression of either gene while or IFN beta *had* a modest inductive effect on IP-10 but no effect on [TNF alpha] expression . Positive_regulation TNF IFNG 2109008 131121 and IL-1 beta alone do not *induce* [TNF-alpha] production , however , the combined treatment of IFN-gamma and IL-1 beta results in a striking synergistic effect on astrocyte TNF-alpha production . Positive_regulation TNF IFNG 2109008 131125 Astrocyte TNF-alpha production by IFN-gamma/LPS stimulation can be inhibited by the addition of anti-rat IFN-gamma antibody , whereas *induced* [TNF-alpha] production is inhibited by antibody to either IFN-gamma or IL-1 beta . Positive_regulation TNF IFNG 2117474 139803 Combining subthreshold doses of IFN gamma liposomes or with lipopolysaccharide synergistically *enhanced* the release of [TNF] . Positive_regulation TNF IFNG 2119829 141843 To elucidate which cytokines produced by monocytes are controlled by IL-4 , we tested the effect of IL-4 on the secretion of IL-1 alpha , IL-1 beta , [TNF alpha] , and IL-6 *induced* by LPS or . Positive_regulation TNF IFNG 2120130 141881 However , IL-3 , together with , *stimulated* the [TNF-alpha] , but not IL-1 , activities of monocytes from several donors . Positive_regulation TNF IFNG 2121882 143908 When IFN gamma and LPS were given together , *enhanced* the LPS induced transcription of [TNF] and KC , suggesting decreased stability of mRNA for KC . Positive_regulation TNF IFNG 2124240 145374 [TNF-alpha] was produced by amastigote infected macrophages and dramatically *enhanced* secretion of this cytokine ; Positive_regulation TNF IFNG 2129500 150646 In contrast , , which induced major histocompatibility complex ( MHC) class II expression , did not *induce* IL-1 or [TNF alpha] production . Positive_regulation TNF IFNG 2129500 150652 However , *enhanced* the cell surface expression of HLA-DR and the production of IL-1 and [TNF alpha] on monocyte enriched cells stimulated by GM-CSF . Positive_regulation TNF IFNG 2143488 140003 Although neither nor TNF alone induce class II molecules on islet cells , synergistic interaction of IFN-gamma ( 200 U/ml ) and [TNF] ( 200 U/ml ) may *induce* class II expression on approximately 50 % of islet cells . Positive_regulation TNF IFNG 21573470 243088 L929 parental cells and L929 cells selected for resistance to tumor necrosis factor ( TNF-alpha ) were incubated in vitro with various concentrations of [TNF-alpha] , interleukin-1 , and lipopolysaccharide (LPS) in the *presence* or absence of mouse . Positive_regulation TNF IFNG 2158515 131606 We found that the addition of IFN-gamma and tumor cells ( either the A375 or HT-29 cells ) to monocytes *induced* [TNF] release , whereas IFN-alpha or alone or IFN-alpha and tumor cells had no effect . Positive_regulation TNF IFNG 2165948 137863 Furthermore , the secretion of [TNF-alpha] in *response* to and LPS is almost absent in macrophages from aged rats . Positive_regulation TNF IFNG 2170030 142095 Both LPS and was *necessary* to increase intracellular [TNF] . Positive_regulation TNF IFNG 2172302 144171 Our observations indicate that TNF-alpha could act in an autocrine fashion to induce the proliferation of this malignant glioma cell line and that TNF-alpha exerts its effect by binding to specific [TNF-alpha] receptors whose expression was *enhanced* by . Positive_regulation TNF IFNG 22492973 2613136 In late CL cells , TNF and [TNF+IFNG+FASL] reduced VEGFR2 mRNA , but *increased* TSP1 and CD36 mRNA . Positive_regulation TNF IFNG 2445926 79884 injection of recombinant ( rIFN-gamma , 10 ( 4 ) U per mouse ) *increased* [TNF] production to 790 U/ml ; Positive_regulation TNF IFNG 2449501 84738 Neither *induction* of [TNF] receptors by nor inhibition of RNA synthesis by actinomycin D increased the susceptibility of TNF-resistant tumor targets to TNF mediated monocyte cytotoxicity . Positive_regulation TNF IFNG 2473862 114878 Further , the selected 3LL variants are gene-regulatory variants rather than cellular mutants , as *upregulation* of the [TNF-alpha] receptor by or 5'-azacytidine treatment resulted in an increased vulnerability of the selected 3LL variants to the killing activity of macrophages and TNF-alpha . Positive_regulation TNF IFNG 2474236 103984 Whereas *induces* secretion of [TNF-alpha] protein , protein secretion of IL-1 by monocytes failed to occur in response to an IFN-gamma stimulus . Positive_regulation TNF IFNG 2492910 105586 The increase of [TNF alpha] was observed in the absence of in vitro stimulation as well as in the *presence* of plus lipopolysaccharide . Positive_regulation TNF IFNG 2493384 107976 Similar results were found when we measured the levels of RNA for the [tumor necrosis factor] and C3 complement genes , both of which are *induced* by in M phi . Positive_regulation TNF IFNG 2495247 108082 However , synergistically *enhanced* lipopolysaccharide (LPS) induced [TNF alpha] and IL-1 activities . Positive_regulation TNF IFNG 2495247 108087 The results of this study suggest that , despite control by cyclo-oxygenase products of TNF alpha and IL-1 production in human monocytes , may *enhance* [TNF alpha] and IL-1 activities independently of this regulatory mechanism . Positive_regulation TNF IFNG 2555395 122051 TNF-alpha exerts its effect by binding to high affinity [TNF-alpha] receptors on astrocytes , whose expression is also *enhanced* by . Positive_regulation TNF IFNG 2561626 125457 In addition , we also found that ACTH 1-39 will potentiate 's *induction* of [TNF-alpha] from these cells . Positive_regulation TNF IFNG 2642503 106731 however , in contrast , to IL-1 beta , [TNF-alpha] mRNA expression was *up-regulated* by both endotoxin and . Positive_regulation TNF IFNG 2793223 119676 *enhanced* [TNF alpha] synthesis in cultures from either SLE patients or controls stimulated by concanavalin A ( Con A ) alone , but depressed the high production of TNF alpha by normal PBMC stimulated with Con A plus PMA . Positive_regulation TNF IFNG 2848629 100470 In order to investigate whether this phenotypic trait of the tumor cells can be modulated by agents known to enhance HLA class I antigen expression , pairs of LCL and BL lines were cultured in the *presence* of recombinant human and [tumor necrosis factor (TNF)-alpha] . Positive_regulation TNF IFNG 3020123 63235 In contrast , *increased* [125I-TNF] binding in both cell lines . Positive_regulation TNF IFNG 3020123 63237 Both IFN-alpha and IFN-beta exerted an antagonistic effect on induced stimulation of TNF receptor expression in HT-29 cells , but did not *inhibit* [TNF] receptor induction by IFN-gamma in HeLa cells . Positive_regulation TNF IFNG 3020123 63238 Despite the inhibitory effect of IFN-beta on the *induced* stimulation of [TNF] receptor expression , IFN-beta did not inhibit the synergistic enhancement of TNF cytotoxicity by IFN-gamma in HT-29 cells . Positive_regulation TNF IFNG 3045826 97118 We also demonstrated that the [IL-2/TNF] synergistic induction of LAK activity did not *involve* either IL-1 or . Positive_regulation TNF IFNG 3087891 61063 No correlation was found between this enhancement of [TNF] sensitivity and the mediated *increase* in TNF-cell membrane receptors , suggesting that IFN-gamma predominantly exerts its synergistic effect distal to TNF binding . Positive_regulation TNF IFNG 3095481 64696 can not induce cachectin biosynthesis by itself , nor does it markedly *enhance* [cachectin] production by endotoxin induced peritoneal macrophages obtained from endotoxin-responsive mice . Positive_regulation TNF IFNG 3098851 69069 Our data show that [TNF] is an important mediator of the cytotoxicity of human monocytes for tumor cells and that can *increase* monocyte cytotoxicity by sensitizing target cells to the lytic action of TNF . Positive_regulation TNF IFNG 3112245 76450 Recombinant *stimulates* the production of human [tumor necrosis factor] in vitro . Positive_regulation TNF IFNG 3117358 79219 The *activation* of tumoricidal murine macrophages by recombinant human [tumor necrosis factor] ( rH-TNF ) alone or in combination with recombinant murine gamma-interferon ( ) was examined . Positive_regulation TNF IFNG 3131488 83454 *augmented* both cytostatic and cytocidal activity of [rHu-TNF] . Positive_regulation TNF IFNG 3141050 99675 Synergistic *enhancement* of the antitumor activity of recombinant human [TNF-alpha] by recombinant human . Positive_regulation TNF IFNG 3141050 99677 *enhanced* both cytostatic and cytocidal activity of [rHu-TNF-alpha] against most rHu-TNF-alpha-sensitive tumor cells in vitro . Positive_regulation TNF IFNG 3148653 103471 Recombinant ( rIFN gamma ) per se is a poor *inducer* of [TNF] release . Positive_regulation TNF IFNG 3149190 103500 When peritoneal macrophages were pretreated with GM-CSF for 24 hrs , a strong reduction of *induced* tumor cytotoxicity and LPS triggered [tumor necrosis factor-alpha (TNF-alpha)] release was found . Positive_regulation TNF IFNG 3258884 91925 The capacity to secrete [TNF] in response to LPS decreased slightly in cultured monocytes but was markedly *augmented* by ( approximately five-fold more than fresh monocytes ) . Positive_regulation TNF IFNG 3499192 79438 Whereas monocytes do not accumulate CSF-1 messenger ( m ) RNA constitutively and consequently do not produce CSF-1 protein , CSF-1 mRNA and protein secretion became detectable , when monocytes were cultured in the presence of [TNF-alpha] , that was synergistically *enhanced* by . Positive_regulation TNF IFNG 7505803 244376 Interleukin 1 (IL-1) , [tumor necrosis factor (TNF)] , and Escherichia coli lipopolysaccharide (LPS) *increased* cGMP at 24 h , whereas IL-2 and IL-6 were ineffective . Positive_regulation TNF IFNG 7513301 253700 Quantification by Northern ( RNA ) blot analyses demonstrated that in combination with TNF-alpha or LPS *increased* markedly the accumulation of mac-NOS and [TNF-alpha] mRNAs in a time dependent manner with a concomitant increase in NO and TNF-alpha production . Positive_regulation TNF IFNG 7537721 287880 L. major induced the production of two competing cytokines in infected macrophages : ( 1 ) the parasite activated the gene for tumor necrosis factor (TNF) , and production of [TNF] protein was *enhanced* by the presence of . Positive_regulation TNF IFNG 7576690 329081 When cells were exposed to a higher number of silica particles , cell activation was attained at shorter times but a substantial number of cells were damaged at 48 h . alone *induced* an increased production of [TNF alpha] in RAW 264.7 cells , not further augmented by a subsequent exposure to silica of the IFN gamma treated cells . Positive_regulation TNF IFNG 7578978 333352 The modulation of IL-6 and [TNF-alpha] release by nitric oxide *following* stimulation of J774 cells with LPS and . Positive_regulation TNF IFNG 7590881 336352 BMM treated with amoebic proteins and stimulated with LPS , or , *resulted* in a 33 % and 50 % reduction in [TNF-alpha] mRNA levels , respectively . Positive_regulation TNF IFNG 7642223 317954 *resulted* in secretion of [TNF-alpha] in day 5 , day 7 , and day 9 BMDM after 4-8 hr of stimulation . Positive_regulation TNF IFNG 7680648 211627 IL-4 down-regulated and *enhanced* the [TNF alpha-] and IL-1 beta induced increase in RANTES mRNA , whereas the induction of IL-8 mRNA by TNF alpha or IL-1 beta was inhibited by IFN gamma and augmented by IL-4 . Positive_regulation TNF IFNG 7683323 216428 MIF and synergize with lipid A to mediate migration inhibition but only IFN-gamma *induces* production of [TNF-alpha] and nitric oxide . Positive_regulation TNF IFNG 7693830 234233 We found that cell lines that are sensitive to [TNF mediated cytotoxicity (TMC)] produced NO in *response* to TNF and , but not in response to IFN-alpha beta . Positive_regulation TNF IFNG 7694216 234262 IFN-alpha and which had no effect alone , synergistically *increased* [TNF] production when applied together with the enzymes . Positive_regulation TNF IFNG 7730628 302372 [TNF-alpha] also *induced* kappa B binding activity that was composed of NF-kappa B1 ( p50 ) and RelA ( p65 ) whereas had no detectable effect on kappa B binding activity . Positive_regulation TNF IFNG 7743669 306074 LPS , or TNF-alpha had no effect on spontaneous IL-6 production , and neither *resulted* in the secretion of IL-1 beta or [TNF-alpha] . Positive_regulation TNF IFNG 7858101 287035 A separate group of female NOD/Lt mice had *stimulated* plasma [TNF-alpha] measured at 10 weeks and were followed to age 30 weeks . Positive_regulation TNF IFNG 7915999 269784 IL-1 beta and [TNF-alpha] *induced* a parallel increase of both the ICAM-1 expression on EC and sICAM-1 production by EC , while induced only the dose dependent enhancement of ICAM-1 expression , but not the production of sICAM-1 , IL-4 and IL-6 did not show any effects on the ICAM-1 expression nor on the sICAM-1 production . Positive_regulation TNF IFNG 7962479 279380 Constitutive production of the cytokine [TNF] , or its liberation in *response* to either or lipopolysaccharide (LPS) alone , was very low in RMG and RPE cells , irrespective of the strain . Positive_regulation TNF IFNG 7963527 279418 We have previously described two factors , IFN-gamma enhanced factor X (IFNEX) and [TNF-alpha induced complex X (TIC-X)] , whose expression is *induced* by and IFN-gamma/TNF-alpha , respectively , which interacted with the X box of the DRA promoter . Positive_regulation TNF IFNG 8009598 258501 This suggests that the release of IL-6 and [TNF-alpha] in MLC is *dependent* on produced by T cells . Positive_regulation TNF IFNG 8049441 267471 By contrast , [TNF alpha] *induced* a 2.5-fold increase in the level of uPAR protein released into conditioned medium ( compared with unstimulated cells ) , whereas had no effect . Positive_regulation TNF IFNG 8063414 268742 These data suggest that both cytokines act in an additive or synergistic fashion in the induction of bacteriostasis and that is also *involved* in priming [TNF-alpha] secretion . Positive_regulation TNF IFNG 8069926 269998 Unlike IL-8 , the LPS stimulated production of [TNF] and IL-1 beta , as well as the TNF stimulated production of IL-1 beta , was markedly *enhanced* by over the entire incubation period ( up to 18 hr ) . Positive_regulation TNF IFNG 8081789 270918 Additional stimulation of LPS treated monocytes with as a priming agent *enhanced* [TNF-alpha] formation in stable function patients and , in contrast , slightly reduced monokine formation in chronic rejection patients , which suggests that in this group a high activation level of monocytes has already been reached in vivo by T cell factors such as IFN-gamma . Positive_regulation TNF IFNG 8097322 217603 We demonstrate that production from SCID splenocytes is stimulated by interleukin (IL) 12 , tumor necrosis factor alpha (TNF-alpha) , and IL-2 but is inhibited by IL-10 , IL-10 , IL-12 , and [TNF] are *induced* by heat killed Listeria monocytogenes ( hk-LM ) from SCID splenocytes and peritoneal macrophages . Positive_regulation TNF IFNG 8144975 252573 greatly *increased* LPS mediated [TNF-alpha] production by human neutrophils ( p < 0.01 ) , and SNP plus NAC was found to further augment this production ( p < 0.01 ) . Positive_regulation TNF IFNG 8145018 252580 Cells were cultivated in the *presence* of and LPS for up to 48 h and changes in the secretion of nitric oxide ( NO. ) and [tumor necrosis factor alpha (TNF-alpha)] were observed as activation markers . Positive_regulation TNF IFNG 8218597 231768 also *induced* increased expression of cell membrane [TNF-R] measured by binding of 125I labeled TNF . Positive_regulation TNF IFNG 8218597 231770 Membrane [TNF-Rs] which were *induced* by were the 75-kDa type , because TNF binding was blocked by anti-75-kDa TNF-R antibody . Positive_regulation TNF IFNG 8218597 231771 These data suggest that selectively *induced* release and expression of 75-kDa [TNF-Rs] . Positive_regulation TNF IFNG 8319779 223127 GM-CSF and combined with 1,25 ( OH ) 2D3 *increased* cellular [TNF] secretion to levels not seen with these agents alone . Positive_regulation TNF IFNG 8366624 229329 Cytolysis , [TNF] activity and NO2- production were *enhanced* by lipopolysaccharide (LPS) and . Positive_regulation TNF IFNG 8371348 229594 In the CD8+ subset , and HIV-1 mutually *enhanced* the production of [TNF alpha] , leading to hyperactivation of viral replication , whereas in CD8- NK cells IFN-gamma primed HIV induced IFN-alpha production . Positive_regulation TNF IFNG 8380280 210136 Porins at 1 microgram/ml induce the greatest release of [TNF-alpha] , IL-1 alpha , and IL-6 by monocytes and of IL-4 by lymphocytes , while porins at 5 micrograms/ml *induce* the greatest release of by lymphocytes . Positive_regulation TNF IFNG 8387619 218050 nIL-1 , IFN gamma and [TNF alpha] could not differentiate between any of the cell lines but and TNF alpha *induced* monocytic surface antigens . Positive_regulation TNF IFNG 8419083 210506 Since it is known that may *induce* the production of [TNF-alpha] , the secretion of this cytokine was examined . Positive_regulation TNF IFNG 8445328 213768 N = O synthesis by KC. Treatment with LPS and also *induced* significant production of prostaglandin E2 ( PGE2 ) , thromboxane B2 (TBX2) , [tumor necrosis factor alpha (TNF-alpha)] , interleukin-1 (IL-1) , and IL-6 . Positive_regulation TNF IFNG 8445328 213774 N = O synthesis by KC. Treatment with LPS and also *induced* significant production of prostaglandin E2 ( PGE2 ) , thromboxane B2 (TBX2) , [tumor necrosis factor alpha (TNF-alpha)] , interleukin-1 (IL-1) , and IL-6 . Positive_regulation TNF IFNG 8519088 222110 IL-1 and [TNF] *induced* 6- and 7-fold increases in the synthesis of C3 and factor B . induced increases in the synthesis of all seven proteins , the most pronounced effects being on the synthesis of C4 and C1 inhibitor -- 15- and 44-fold , respectively . Positive_regulation TNF IFNG 8675208 369795 and IL-4 *increased* lipopolysaccharide (LPS) induced [TNF-alpha] , IL-1 steady-state message levels . Positive_regulation TNF IFNG 8742066 377131 We therefore investigated the influence of differentiation over 15 days in vitro on the spontaneous and LPS- and *induced* release of [TNF-alpha] and sTNF-R from human monocytes and examined the actions of IL-4 and IL-10 on these . Positive_regulation TNF IFNG 8746784 343501 We demonstrated here that [TNF-alpha] induced binding of NF kappa B p50 and p65 to the NF kappa B-like element of the MHC class I promoter termed region I and *induced* binding of IRF-1 to the adjacent interferon consensus sequence ( ICS ) . Positive_regulation TNF IFNG 8757859 377764 We also measured bioactive [TNF-alpha] release by infected macrophages in the *presence* or absence of . Positive_regulation TNF IFNG 8877395 390481 In addition , *enhancement* of [TNF-alpha] production by was also suppressed by rMNSF beta . Positive_regulation TNF IFNG 8901434 393543 did not *increase* the low level of endogenous [TNF alpha] , which is not secreted by embryonic cells , but stimulated the expression of TNF alpha R1 , although to a relatively low extent . Positive_regulation TNF IFNG 8906830 394395 These data suggest that the aggregate IL-12 p40 and p70 response to endotoxemia in vivo is IFN-gamma independent and distinct from *dependent* serum [TNF-alpha] and splenic IL-12 responses . Positive_regulation TNF IFNG 8932272 397979 *induces* the production of inflammatory cytokines , e.g. , [tumor necrosis factor-alpha] and interleukin (IL)-1 , which are the distal mediators of GVHD . Positive_regulation TNF IFNG 9010676 405078 *enhances* [tumor necrosis factor-alpha] production by inhibiting early phase interleukin-10 transcription . Positive_regulation TNF IFNG 9010676 405079 profoundly *enhances* LPS stimulated [TNF-alpha] production , whereas IL-10 is markedly inhibitory , demonstrating the opposing effects of IFN-gamma and IL-10 on BMDM . Positive_regulation TNF IFNG 9015376 411948 The soluble factors were able to induce TNF-alpha in the macrophages and to potentiate the [TNF-alpha] release *induced* by . Positive_regulation TNF IFNG 9029133 413589 in contrast , their levels of IL-1 beta , IL-4 , and were normal and their levels of IL-2 and [TNF-alpha] were marginally *increased* . Positive_regulation TNF IFNG 9058823 417714 Granulocyte-macrophage colony stimulating factor and *restore* the systemic [TNF-alpha] response to endotoxin in lipopolysaccharide desensitized mice . Positive_regulation TNF IFNG 9058823 417720 In cultures of murine monocyte/macrophage containing cell populations , i.e. , alveolar , peritoneal , spleen , bone marrow cells , or blood , the presence of GM-CSF or ( 10 ng/ml ) *resulted* in an enhanced release of [TNF-alpha] initiated by 1 microg/ml LPS . Positive_regulation TNF IFNG 9145305 429698 The [TNF] and NOS II mRNA expression and TNF and nitrite synthesis *induced* in RMG cells from both strains by LPS + was significantly prevented by including transforming growth factor-beta ( TGF-beta ) in the culture medium . Positive_regulation TNF IFNG 9164938 432133 RelB binds transcriptionally active kappaB motifs in the TNF-alpha promoter in normal cells , and in vitro studies with macrophages isolated from RelB-deficient animals revealed impaired production of [TNF-alpha] in *response* to LPS and . Positive_regulation TNF IFNG 9176497 433748 Moreover , applied to septic patients with low monocytic HLA-DR expression *restored* the deficient HLA-DR expression and in vitro LPS induced [TNF-alpha] secretion . Positive_regulation TNF IFNG 9184793 436676 In contrast , *stimulation* of AM production of [TNF-alpha] by was not affected by DEP exposure . Positive_regulation TNF IFNG 9285295 451889 At nine months Con A-induced [TNF-alpha] secretion decreased significantly below baseline but secretion *increased* above baseline . Positive_regulation TNF IFNG 9389504 467120 *potentiated* LPS effect on IL-6 and [TNF alpha] levels in both CSF and serum . Positive_regulation TNF IFNG 9408610 471362 A local increase in gene expression *increased* a local expression of inducible nitric oxide synthase (iNOS) and the [tumor necrosis factor] a gene . Positive_regulation TNF IFNG 9449707 483979 In the *presence* of , IL-18 induced [TNFalpha] was enhanced and there was an increase in the mature form of IL-1beta . Positive_regulation TNF IFNG 9459614 475712 The results suggest that in inflammatory processes , GM-CSF and *contribute* to increased synthesis of [TNF-R75] by monocytic cells , a prerequisite for the formation of large amounts of soluble receptors . Positive_regulation TNF IFNG 9506551 491426 The activation of these pathways , one *activated* by and the other by the combination [TNFalpha/IL-2/IL-6] , is independent from myelin antigens and precedes by 2 weeks phases of disease activity ( eg , clinical relapses and/or appearance of gadolinium enhancing lesions on brain magnetic resonance imaging scans during 1 year of follow-up ) . Positive_regulation TNF IFNG 9520166 493481 Concerning PBMC , the production of [TNF-alpha] and IL-12 in *response* to LPS , or LPS plus , was found to be significantly higher in cells isolated from HIV positive patients , whereas the release of IL-1beta was significantly lower . Positive_regulation TNF IFNG 9536945 497502 In contrast , *had* no significant effect on [TNF-alpha] stimulated IL-8 secretion . Positive_regulation TNF IFNG 9541578 498077 *induced* [TNF-alpha] is a prerequisite for in vitro production of nitric oxide generated in murine peritoneal macrophages by IFN-gamma . Positive_regulation TNF IFNG 9541578 498078 Accordingly , the failure of M phi from C3H/HeJ mice to secrete [TNF-alpha] upon *stimulation* with was associated with their complete incapability to generate NO , unless they were simultaneously treated with IFN-gamma + TNF-alpha . Positive_regulation TNF IFNG 9543699 498245 These findings appear to suggest that PLD derived phosphatidate is not the primary source of DAG production in *induced* [TNF-alpha] secretion , but may be necessary for IFN-gamma mediated MHC class II induction and IL-1 beta production in human monocytes , whereas phospholipase A2 may not be required for IFN-gamma activation of PKC in the process . Positive_regulation TNF IFNG 9555975 499214 We previously demonstrated that iNOS can be induced in cultured bovine monocytes in *response* to and [TNF-alpha] but lose this capability in a short period of time . Positive_regulation TNF IFNG 9573098 501946 When RAW264.7 cells were pretreated with human [TNF] or TNF ( 70-80 ) in the *presence* of , there was a dose dependent reduction in the replication of BCG as measured by the uptake of 3H-labeled uracil and a concomitant release of nitric oxide as measured by the nitrite in the culture supernatants . Positive_regulation TNF IFNG 9577963 503183 Studies showed that beta1,3-glucan , IL-beta , [TNFalpha] and IFNgamma/TNFalpha *induced* expression and production of CINC in macrophages while neither nor TGFbeta alone induced detectable CINC expression . Positive_regulation TNF IFNG 9651816 515609 These results indicate that the stimulation of Fas antigen or [TNF] receptor increases Mn-SOD activity of SVHK cells in the *presence* of and that TPA augments the process through the activation of protein kinase C . Positive_regulation TNF IFNG 9657919 516878 IL-1beta and [TNF-alpha] synergistically *induced* IL-6 and GM-CSF and additively induced IL-8 and MCP-1 production , while IL-2 , IL-10 , IFN-alpha , and had little or no additional effects . Positive_regulation TNF IFNG 9770326 538794 Specifically , TNF-alpha-and *induced* nitric oxide production and [TNF-alpha-] and IL-1beta induced expression of the alpha-chemokine , KC , were intact in ASMase null macrophages . Positive_regulation TNF IFNG 9820155 547467 HSV-2 infection and stimulation of macrophages synergistically *induced* [TNF-alpha] secretion and nuclear translocation of NF-kappaB , which bound to a sequence corresponding to a kappaB site in the iNOS promoter . Positive_regulation TNF IFNG 9848688 554047 itself also *induced* NO , [TNF-alpha] and IL-6 production from RAW 264.7 cells . Positive_regulation TNF IFNG 9879689 557388 stimulation significantly reduced the production of IL-6 but *increased* [TNFalpha] production . Positive_regulation TNF IFNL1 20726961 2368184 the released further *triggered* the release of IL-6 and [tumor necrosis factor] from CD4 ( + ) T cells . Positive_regulation TNF IFNL1 21190998 2391298 Furthermore , IL-29 treated macrophages were more responsive to IFN? , because *enhanced* IFN? induced IL-12p40 and [tumor necrosis factor (TNF)] production by macrophages on R848 stimulation . Positive_regulation TNF IGF1 11876931 893907 Additionally , rhGH ( at 40 ng/ml ) and ( at all tested concentrations ) could *activate* the secretion of [TNF] and IL-6 from cultured mice Mphi in vitro . Positive_regulation TNF IGF1 12058282 952593 Correspondingly , markedly *enhanced* the [TNF-] and IFN/TNF induced NF-kappaB dependent interleukin-8 production . Positive_regulation TNF IGF1 12930919 1164039 Furthermore , inhibited apoptosis of CB DC and *increased* the production of [tumor necrosis factor alpha (TNF-alpha)] . Positive_regulation TNF IGF1 12930919 1164048 These effects are mediated through both MEK and PI 3-kinase pathways but not through the *induction* of [TNF-alpha] production by the DC . Positive_regulation TNF IGF1 23677929 2801112 Thereby , IGF-II or [TNF-a] *induced* IRA and IGF-I receptor (IGF-IR) overexpression as well as an increase of hybrid receptors in VSMCs . Positive_regulation TNF IGF1 8895324 392458 Preexposure of macrophages with specific antibodies against IGF-I and IGF-I receptor before IGF-I addition resulted in a complete abrogation of the stimulatory effect of IGF-I on TNF alpha production , indicating that specific binding of IGF-I to its receptor is required for macrophage [TNF alpha] *induction* by . Positive_regulation TNF IGF1 8895324 392461 To assess the role of the tyrosine kinase system in mediating *induced* basal [TNF alpha] production , macrophages were preincubated with the specific tyrosine kinase inhibitors , genistein and tyrphostin A9 , before IGF-I exposure . Positive_regulation TNF IGF1 8895324 392462 Addition of these compounds resulted in a dose dependent inhibition of the stimulatory effect of IGF-I on macrophage TNF alpha release , indicating that protein tyrosine kinase activation is required for [TNF alpha] *stimulation* by . Positive_regulation TNF IGF2 23677929 2801113 Thereby , IGF-II or [TNF-a] *induced* IRA and IGF-I receptor (IGF-IR) overexpression as well as an increase of hybrid receptors in VSMCs . Positive_regulation TNF IGF2 8895324 392460 In contrast to the stimulatory effect of IGF-I , neither GH ( 0.1-10 micrograms/ml ) nor ( 0.13-130 nM ) *enhanced* macrophage [TNF alpha] release in vitro . Positive_regulation TNF IGKV1-27 12167698 973188 inhibits [tumor necrosis factor (TNF)] alpha *induced* apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells . Positive_regulation TNF IGKV1-27 15862966 1401050 [TNF] *induced* gene expression in both cell lines , but with different effect . Positive_regulation TNF IKBKAP 12867425 1141839 A role for NF-kappaB essential modifier/IkappaB kinase-gamma ( NEMO/IKKgamma ) ubiquitination in the *activation* of the by [tumor necrosis factor-alpha] . Positive_regulation TNF IKBKB 10022904 590579 In contrast , the inhibition of alphaPKC does not affect the *activation* of by [TNF-alpha] . Positive_regulation TNF IKBKB 10195894 603960 In mammalian cells , phosphorylation of two sites at the activation loop of IKKbeta was essential for *activation* of by [tumor necrosis factor] and interleukin-1 . Positive_regulation TNF IKBKB 11124824 768961 We analyzed the differential *role* of I kappa B kinase 1 (IKK1) and in [tumor necrosis factor alpha (TNF-alpha)-] and interleukin-1 beta (IL-1 beta) mediated NF-kappa B activation in primary rat hepatocytes . Positive_regulation TNF IKBKB 11356844 834445 The present study shows that PTEN , a tumor suppressor that inhibits PI 3-kinase function , impairs [TNF] *activation* of Akt and the in 293 cells . Positive_regulation TNF IKBKB 11479295 860523 Since oxidants have been implicated in the regulation of NF-kappaB , the focus of the present study was the *activation* of by [tumor necrosis factor alpha (TNFalpha)] in the presence or absence of hydrogen peroxide ( H ( 2 ) O ( 2 ) ) . Positive_regulation TNF IKBKB 11479295 860541 In contrast , [TNFalpha] *induced* activity rapidly and transiently resulting in IkappaBalpha degradation and NF-kappaB activation . Positive_regulation TNF IKBKB 11955956 930877 These observations demonstrate that the intracellular Ca2+ may *play* an important role in IgE induced [TNF-alpha] and IL-6 secretion from mast cells via activation . Positive_regulation TNF IKBKB 12181188 977493 In conclusion , Fe2+ serves as a direct agonist to activate , NF-kappaB , and TNF-alpha promoter activity and to *induce* the release of [TNF-alpha] protein by cultured Kupffer cells in a redox status dependent manner . Positive_regulation TNF IKBKB 12482991 1032861 Experiments with IKK1 ( -/- ) and IKK2 ( -/- ) double knockout embryonic fibroblasts demonstrate that the is *essential* for [TNF-alpha] to stimulate phosphorylation on p105 serines 927 and 932 . Positive_regulation TNF IKBKB 12847684 1109024 To investigate the potential *role* of IkappaB kinase 1 (IKK-1) and in the regulation of nuclear factor kappaB (NF-kappaB) activation and the expression of [tumor necrosis factor alpha (TNFalpha)] , as well as interleukin-1beta (IL-1beta) , IL-6 , IL-8 , vascular endothelial growth factor ( VEGF ) , and matrix metalloproteinases ( MMPs ) , in rheumatoid arthritis ( RA ) . Positive_regulation TNF IKBKB 12847684 1109047 was not *required* for lipopolysaccharide (LPS) induced NF-kappaB activation or [TNFalpha] , IL-6 , or IL-8 production in macrophages , but was essential for this process in response to CD40 ligand , TNFalpha , and IL-1 . Positive_regulation TNF IKBKB 12847684 1109053 Our study demonstrates that is not *essential* for [TNFalpha] production in RA . Positive_regulation TNF IKBKB 12867425 1141840 A role for NF-kappaB essential modifier/IkappaB kinase-gamma ( NEMO/IKKgamma ) ubiquitination in the *activation* of the by [tumor necrosis factor-alpha] . Positive_regulation TNF IKBKB 12867425 1141855 Thus , the ubiquitination of NEMO mediated by c-IAP1 likely plays an important role in the *activation* of by [TNF-alpha] . Positive_regulation TNF IKBKB 12934647 1132828 IL-1beta and [TNF-alpha] can *induce* extracellular signal regulated kinase ( ERK ) , , IkappaB degradation and NF-kappaB activation . Positive_regulation TNF IKBKB 14630816 1210103 In contrast , in macrophages neither MyD88 , Mal/TIRAP , nor are *required* for NF-kappa B activation or [tumor necrosis factor alpha (TNF alpha)] , IL-6 , or IL-8 production , although Mal/TIRAP is still involved in the production of interferon beta (IFN beta) . Positive_regulation TNF IKBKB 14764716 1207360 The *activation* of the complex by [TNF] or LPS stimulates phosphorylation and degradation of I-kappaBalpha , leading to the nuclear translocation of NF-kappaB . Positive_regulation TNF IKBKB 15106733 1240534 [TNF-alpha] plus IFN-gamma can *induce* extracellular signal regulated kinase ( ERK ) , , IkappaB degradation and NF-kappaB activation . Positive_regulation TNF IKBKB 15316093 1353568 In the present study , we demonstrate that a novel , potent ( IC ( 50 ) = 17.9 nM ) , and selective inhibitor of human , 2- [ ( aminocarbonyl ) amino ] -5- ( 4-fluorophenyl ) -3-thiophenecarboxamide ( TPCA-1 ) , *inhibits* lipopolysaccharide induced human monocyte production of [TNF-alpha] , IL-6 , and IL-8 with an IC ( 50 ) = 170 to 320 nM . Positive_regulation TNF IKBKB 15611276 1357382 The LPS triggered induction of [TNF-alpha] in monocytes is *dependent* on activity , as confirmed by IKK-specific antisense oligodeoxynucleotides . Positive_regulation TNF IKBKB 15980040 1465292 Overexpression of dominant negative p65 reduced TNF-alpha production 3.5-fold , whereas overexpression of dominant negative *reduced* LPS induced [TNF-alpha] production 2-fold and p65 phosphorylation 2-fold . Positive_regulation TNF IKBKB 16603398 1550696 *Activation* of by [TNFalpha] requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO . Positive_regulation TNF IKBKB 16723255 1570416 In cells progressing through S-phase , [TNFalpha] *activation* of , JNK , and p38 is significantly reduced . Positive_regulation TNF IKBKB 16774932 1672078 The use of Ro-318220 and GO-6983 , general PKC inhibitors as well as MG-132 , a proteasome-specific inhibitor , abrogated PMA induced degradation of IKK-gamma and recovered the *activation* of by [TNF] , suggesting that IKK complex is predominantly degraded by the proteasome pathway in a PKC dependent manner . Positive_regulation TNF IKBKB 17495962 1791833 Bay 11-7085 , an inhibitor of , *reduced* [tumor necrosis factor-alpha (TNFalpha)] production from LPS stimulated XS52 cells and inhibited the ability of LC to present antigen to a T-cell clone in vitro . Positive_regulation TNF IKBKB 17940218 1830560 The present study demonstrates that the globular domain of adiponectin ( gAd ) potently suppresses the *activation* of by either [TNFalpha] or high glucose in human umbilical vein endothelial cells and ameliorates the associated loss of IkappaBalpha protein . Positive_regulation TNF IKBKB 18411264 1914322 *Activation* of by gamma radiation or [tumor necrosis factor-alpha] led to increased TAp63gamma protein levels in cells . Positive_regulation TNF IKBKB 18930133 2013556 PPM1A and PPM1B associate with the phosphorylated form of IKKbeta , and the interaction between PPM1A/PPM1B and is *induced* by [TNFalpha] in a transient fashion in the cells . Positive_regulation TNF IKBKB 19150425 2026746 The combined data reveal that phosphorylation of TRAF2 *plays* a critical role in [TNF] signaling by directing the to the membrane , promoting TRAF2 K63 linked ubiquitination , and positioning the IKKalpha and IKKbeta chains with the TAK1/TAB kinase . Positive_regulation TNF IKBKB 19200052 2033735 Further studies show that neither overexpression of , a kinase inactive mutant of IKKbeta , nor the ectopic expression of a dominant negative mutant of NFAT could *inhibit* the [TNF-alpha] induction by nickel exposure . Positive_regulation TNF IKBKB 21571356 2470230 PBMCs from control subjects were stimulated with [TNF-a] and cigarette smoke extract in the *presence* or absence of fluticasone propionate ( FP ) , L-glutathione reduced , or both , and activation and IL-8 release were evaluated . Positive_regulation TNF IKBKB 24437486 2922605 After administration of a nonselective ß-adrenergic receptor blocker ( propranolol ) before induction of cerebral ischemic injury , hepatic adrenergic transduction , [TNF-a] expression , ER stress , and the *activation* of the JNK1/2 , , and NF-?B pathways , and serine phosphorylation of IRS-1 were all attenuated . Positive_regulation TNF IKBKE 15939554 1420824 We have found that the expression was constitutive in human chondrocytes from OA cartilage and a human chondrocytic cell line C28/I2 but was *up-regulated* by the inflammatory cytokines [TNFalpha] or IL-1betain an NFkappaB dependent manner . Positive_regulation TNF IKBKE 16199137 1531967 The data suggest that is not *involved* in [TNF-alpha] mediated signaling but instead could likely play a role in activating IKK2 downstream of Toll-like receptor signaling . Positive_regulation TNF IKBKE 17328045 1711884 Antiviral gene expression in RA , especially due to TLR ligands and [TNFalpha] , is *dependent* on and IRF-3 , and this pathway plays a key role in the production of type I IFNs and chemokines such as RANTES . Positive_regulation TNF IKBKG 10195894 603961 In mammalian cells , phosphorylation of two sites at the activation loop of IKKbeta was essential for *activation* of by [tumor necrosis factor] and interleukin-1 . Positive_regulation TNF IKBKG 10893415 730545 Overexpression of either or IKAP *blocked* [tumor necrosis factor] alpha induction of an NF-kappa B-dependent reporter construct , but IKAP in addition affected several NF-kappa B-independent promoters . Positive_regulation TNF IKBKG 11356844 834446 The present study shows that PTEN , a tumor suppressor that inhibits PI 3-kinase function , impairs [TNF] *activation* of Akt and the in 293 cells . Positive_regulation TNF IKBKG 11479295 860524 Since oxidants have been implicated in the regulation of NF-kappaB , the focus of the present study was the *activation* of by [tumor necrosis factor alpha (TNFalpha)] in the presence or absence of hydrogen peroxide ( H ( 2 ) O ( 2 ) ) . Positive_regulation TNF IKBKG 11479295 860542 In contrast , [TNFalpha] *induced* activity rapidly and transiently resulting in IkappaBalpha degradation and NF-kappaB activation . Positive_regulation TNF IKBKG 12181188 977494 In conclusion , Fe2+ serves as a direct agonist to activate , NF-kappaB , and TNF-alpha promoter activity and to *induce* the release of [TNF-alpha] protein by cultured Kupffer cells in a redox status dependent manner . Positive_regulation TNF IKBKG 12482991 1032862 Experiments with IKK1 ( -/- ) and IKK2 ( -/- ) double knockout embryonic fibroblasts demonstrate that the is *essential* for [TNF-alpha] to stimulate phosphorylation on p105 serines 927 and 932 . Positive_regulation TNF IKBKG 12867425 1141856 Thus , the ubiquitination of NEMO mediated by c-IAP1 likely plays an important role in the *activation* of by [TNF-alpha] . Positive_regulation TNF IKBKG 12934647 1132829 IL-1beta and [TNF-alpha] can *induce* extracellular signal regulated kinase ( ERK ) , , IkappaB degradation and NF-kappaB activation . Positive_regulation TNF IKBKG 14764716 1207361 The *activation* of the complex by [TNF] or LPS stimulates phosphorylation and degradation of I-kappaBalpha , leading to the nuclear translocation of NF-kappaB . Positive_regulation TNF IKBKG 15106733 1240535 [TNF-alpha] plus IFN-gamma can *induce* extracellular signal regulated kinase ( ERK ) , , IkappaB degradation and NF-kappaB activation . Positive_regulation TNF IKBKG 15611276 1357383 The LPS triggered induction of [TNF-alpha] in monocytes is *dependent* on activity , as confirmed by IKK-specific antisense oligodeoxynucleotides . Positive_regulation TNF IKBKG 16603398 1550697 *Activation* of by [TNFalpha] requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO . Positive_regulation TNF IKBKG 16723255 1570417 In cells progressing through S-phase , [TNFalpha] *activation* of , JNK , and p38 is significantly reduced . Positive_regulation TNF IKBKG 16774932 1672079 The use of Ro-318220 and GO-6983 , general PKC inhibitors as well as MG-132 , a proteasome-specific inhibitor , abrogated PMA induced degradation of IKK-gamma and recovered the *activation* of by [TNF] , suggesting that IKK complex is predominantly degraded by the proteasome pathway in a PKC dependent manner . Positive_regulation TNF IKBKG 17000764 1647280 Furthermore , dimerization is *required* for the [tumor necrosis factor] alpha induced NF-kappaB activation , even when interaction with the IKKs is unaffected . Positive_regulation TNF IKBKG 17495962 1791834 Bay 11-7085 , an inhibitor of , *reduced* [tumor necrosis factor-alpha (TNFalpha)] production from LPS stimulated XS52 cells and inhibited the ability of LC to present antigen to a T-cell clone in vitro . Positive_regulation TNF IKBKG 19150425 2026747 The combined data reveal that phosphorylation of TRAF2 *plays* a critical role in [TNF] signaling by directing the to the membrane , promoting TRAF2 K63 linked ubiquitination , and positioning the IKKalpha and IKKbeta chains with the TAK1/TAB kinase . Positive_regulation TNF IKBKG 21571356 2470231 PBMCs from control subjects were stimulated with [TNF-a] and cigarette smoke extract in the *presence* or absence of fluticasone propionate ( FP ) , L-glutathione reduced , or both , and activation and IL-8 release were evaluated . Positive_regulation TNF IKBKG 22513115 2602008 differentially *regulates* TCR and [TNF-a] induced NF-?B pathways and has an inhibitory role in TCR induced NF-?B activation . Positive_regulation TNF IKBKG 24437486 2922606 After administration of a nonselective ß-adrenergic receptor blocker ( propranolol ) before induction of cerebral ischemic injury , hepatic adrenergic transduction , [TNF-a] expression , ER stress , and the *activation* of the JNK1/2 , , and NF-?B pathways , and serine phosphorylation of IRS-1 were all attenuated . Positive_regulation TNF IL10 10201904 605665 [TNF-alpha] *induced* tyrosine phosphorylation and enzymatic activation of ERK2 , SAPK/JNK , and p38mapk , whereas did not induce these events . Positive_regulation TNF IL10 10332965 614908 exerted inhibitory effects on both CD40 ligation induced and CD40 ligation plus IFN-gamma *induced* [TNF-alpha] production by ST cells . Positive_regulation TNF IL10 10452106 637585 Both endogenous and exogenous nitric oxide and *had* inhibitory effects on the LPS induced [TNF alpha] , IL-1 beta , and IL-6 secretions in mouse AM . Positive_regulation TNF IL10 10880238 709101 Two distinct tyrosine kinase inhibitors , herbimycin and genistein affected the expression of [TNF-R] in *response* to but , surprisingly , with opposite effects . Positive_regulation TNF IL10 10969796 728397 decreased the production of IL-6 and the expression of IL-12 in the presence of TNF-alpha or sCD40L , but it *had* no effect on IL-15 , IL-18 , and [TNF-alpha] secretion . Positive_regulation TNF IL10 11012758 736156 Because is *involved* in the UV-induced suppression of delayed-type hypersensitivity and [TNF-alpha] in the UV-induced suppression of contact allergy , these findings provide a mechanism to explain how rIL-12 overcomes UV-induced immune suppression in these related but different immune reactions . Positive_regulation TNF IL10 11052826 743474 High plasma levels at diagnosis of ALL *had* no effect on the ex vivo [TNF-alpha] and IL-1beta production of monocytes in LPS stimulated MNC cultures . Positive_regulation TNF IL10 11073113 748781 Morphine *enhanced* mRNA expression of interleukin (IL)-12 p40 and [tumor necrosis factor alpha (TNF-alpha)] compared with controls , whereas levels were unchanged by drug treatment . Positive_regulation TNF IL10 11323220 807292 *augments* the IFN-gamma and [TNF-alpha] induced TARC production in HaCaT cells : a possible mechanism in the inflammatory reaction of atopic dermatitis . Positive_regulation TNF IL10 11342369 812699 Although *increased* serum IL-1beta and [TNFalpha] levels , IL-4 had no effect on them . Positive_regulation TNF IL10 11432585 831924 inhibits polymethylmethacrylate particle *induced* interleukin-6 and [tumor necrosis factor-alpha] release by human monocyte/macrophages in vitro . Positive_regulation TNF IL10 11469886 840937 We examined the *role* of endogenous in the regulation of NF-kappaB activation and [TNF-alpha] production in human monocytes by cAMP . Positive_regulation TNF IL10 11943316 928687 The objectives of this study were to determine interleukin (IL)-1 beta , IL-2 , IL-4 , IL-5 , IL-6 , IL-8 , , interferon (IFN)-gamma and [tumor necrosis factor (TNF)-alpha] *induction* in bronchoalveolar lavage (BAL) of control horses and horses with heaves both during remission and exacerbation of the disease , and to determine the effect of therapy with inhaled fluticasone propionate on the cytokine profile of horses with heaves . Positive_regulation TNF IL10 11998908 939565 We speculated that [TNF-alpha] is related to demyelination and that is *induced* to modulate TNF-alpha induced inflammation in ADEM . Positive_regulation TNF IL10 12411792 1010930 Stored allogeneic whole blood resulted in a significant [TNF-alpha] depression ( -61 % ) and *induction* ( +221 % ) . Positive_regulation TNF IL10 12414777 1011162 During the acute phase , IFN-gamma and [TNF-alpha] *induced* increases in IL-2 , sIL-2R , , and sCD30 levels in serum , which allowed the development of immunity characterized by the nonreactivity of the HBV surface antigen , the onset of antibodies to the HBV surface antigen ( anti-HBs ) , and normal alanine aminotransferase levels during the convalescent phase . Positive_regulation TNF IL10 14726820 1198267 Increased IFNgamma , [TNFalpha] , and IL-6 expressions were present , but expression only *increased* in later stages . Positive_regulation TNF IL10 14760940 1182293 We have seen that Gram-positives preferentially *induce* IL-12 and [TNF-alpha] , whereas Gram-negatives induce more , IL-6 , and IL-8 . Positive_regulation TNF IL10 15219461 1263913 IL-6 , but not [TNF-alpha] , release is enhanced by PGE ( 2 ) in the *presence* of , suggesting that endogenous IL-10 masks PGE ( 2 ) -induced IL-6 . Positive_regulation TNF IL10 15220936 1295699 The IFNgamma produced by PMN was biologically active , as demonstrated by its ability to induce [TNFalpha] synthesis by PMN themselves or to *induce* synthesis by peripheral blood mononuclear cells . Positive_regulation TNF IL10 15319486 1303765 These results show that DEP , through eDEP mediated ROS , *induce* HO-1 expression and production and at the same time inhibit AM production of [TNF-alpha] and IL-12 to dampen the host immune responses . Positive_regulation TNF IL10 15325406 1287150 At 50 ng ml(-1) , significantly *increased* [TNF-alpha] but not IL-6 responses to TSST and enterotoxin A . Positive_regulation TNF IL10 15364101 1294057 All bacteria *induced* marked secretion of IL-12 and [TNFalpha] by cells , while only coliforms induced production of ; Positive_regulation TNF IL10 15452036 1324331 In control pregnancies ( n=34 ) , mean levels *increased* 38 % ( P=0.012 ) and [tumor necrosis factor-alpha (TNF-alpha)] by 33 % ( P=0.024 ) between the first and third trimesters . Positive_regulation TNF IL10 15466252 1359216 Acute induction of *resulted* in significant decreases in bronchoalveolar lavage fluid neutrophils ( 48 % , P = 0.03 ) and [TNF] ( 62 % , P < 0.01 ) following intratracheal LPS compared with bitransgenic negative mice . Positive_regulation TNF IL10 15517620 1328642 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL10 15566949 1343546 Hz phagocytosed monocyte/macrophages ( MO/MQ ) secreted high levels of IL-10 , IL-1beta and [TNF-alpha] , but inhibition of proliferation was *mediated* by alone which was reversed by neutralization of the cytokine . Positive_regulation TNF IL10 15652945 1364374 IEL cytokine mRNA expression was also significantly altered with TPN : IL-2 and expression declined , and IL-4 IL-6 , interferon gamma (IFN-gamma) , transforming growth factor beta-1 ( TGF-beta1 ) , and [tumor necrosis factor-alpha (TNF-alpha)] were *increased* , when compared with Control or TPN+Food mice . Positive_regulation TNF IL10 15761496 1397161 This was followed by a significant increase in levels of , whereas IFN-gamma gene upregulation was more transient , and levels of [TNF-alpha] and MIP-1alpha/beta transcripts did not *increase* in either blood or tissues . Positive_regulation TNF IL10 15809201 1391981 Cultured alveolar macrophages from patients with idiopathic pulmonary fibrosis ( IPF ) show dysregulation of lipopolysaccharide induced [tumor necrosis factor-alpha (TNF-alpha)] and *inductions* . Positive_regulation TNF IL10 15881414 1353098 Intraamniotic infection *induced* high levels of [TNF-alpha] in amniotic fluids which correlated with bacterial virulence whereas was induced only by O86 . Positive_regulation TNF IL10 1598496 188828 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL10 16518767 1531095 Tumor necrosis factor (TNF)-alpha and mRNA expression was elevated in H. pylori infected mice , but only [TNF-alpha] mRNA expression was further *increased* by COX deficiency . Positive_regulation TNF IL10 16776679 1573091 In addition IL-4 , IFN-gamma , and were elevated in SAC and VKC , while eotaxin and [TNF-alpha] were only *increased* in VKC . Positive_regulation TNF IL10 16925527 1603312 SOCS3 over-expression had no effect on [TNF-alpha] mRNA levels *induced* by LPS or LPS plus , or on IL-10 phosphorylation of STAT3 , STAT1 and ERK1/2 . Positive_regulation TNF IL10 17022949 1641519 Relative to saline administration , IL1beta increased IL1beta , [TNFalpha] and IL6 mRNAs in the nucleus tractus solitarius (NTS) , hypothalamus , hippocampus and somatosensory cortex ( SSctx ) , but did not *induce* any changes in . Positive_regulation TNF IL10 17082598 1643228 The FcgammaRIIB blockade inhibits GXM induced production and *induces* [TNF-alpha] secretion . Positive_regulation TNF IL10 17201660 1663257 Increased gene expression *contributed* to significantly reduced % IFN-gamma ( + ) and % [TNF-alpha] ( + ) , but not % CD25 ( + ) , as determined by IL-10 neutralization assay . Positive_regulation TNF IL10 17444956 1729830 OPN increased CD69 and CD25 expression and enhanced T-cell IFN-gamma and [TNF-alpha] production in a dose dependent fashion with higher levels in CD than in healthy controls ( HC ) , but *induced* a concomitant higher production in HC than CD . Positive_regulation TNF IL10 17471309 1731986 In the in vitro culture experiments , induced CX3CR1 expression on the surface of monocytes , and [TNFalpha] *induced* membrane bound FKN as well as soluble FKN expression in synovial fibroblasts . Positive_regulation TNF IL10 17484771 1778186 LPS induced production of tumour necrosis factor-alpha (TNF-alpha) , interleukin-6 (IL-6) , and interferon-gamma-inducible protein-10 (IP-10); SA *induced* [TNF-alpha] , and IL-1beta production ; Positive_regulation TNF IL10 17565907 1753566 Ctx suppressed [TNFalpha] secretion by MoDC , but *induced* production . Positive_regulation TNF IL10 18050733 1833247 When the cells were pretreated with GbE ( 0.1 , 1 , and 10 microg x L ( -1 ) ) , the increases of IL-1beta and [TNF-alpha] in U937 foam cells were remarkably inhibited , but expression *increased* greatly . Positive_regulation TNF IL10 18330588 1904655 At low concentration ( 1.6 mM ) , Li *enhanced* [TNFalpha] secretion , whereas , at higher concentration ( 5 mM ) , Li significantly enhanced expression and secretion . Positive_regulation TNF IL10 18464247 1965410 In 8 week HRNF reach limb tissues , IL-1 alpha , IL-1beta , TNFalpha , and *increased* in distal bones , IL-1 alpha and -beta in muscles , and [TNFalpha] in tendons . Positive_regulation TNF IL10 18641346 1937688 The results showed that deficiency *resulted* in significantly higher bacteremia , higher [TNF] levels , and early mortality . Positive_regulation TNF IL10 18793216 2053054 Similar [TNF-alpha] suppression and *induction* by PCERA-1 were observed in macrophages when activated by Toll-like receptor 4 (TLR4) , TLR2 and TLR7 agonists . Positive_regulation TNF IL10 18793216 2053056 In conclusion , the anti-inflammatory activity of PCERA-1 seems to be mediated by a cell membrane receptor , upstream of cAMP production , and eventually [TNF-alpha] suppression and *induction* . Positive_regulation TNF IL10 18810777 1969941 S. thermophilus *induced* the expression of pro-inflammatory ( [TNF-alpha] , IL-12 , IL-6 , and CCL20 ) and Th1 type ( IL-12 and IFN-gamma ) cytokines , while B. breve and L. lactis were also potent inducers of anti-inflammatory . Positive_regulation TNF IL10 19167238 2038581 When EPO was given prior to a bolus injection with endotoxin , the levels of [TNF-alpha] and IL-6 were *enhanced* by 5- and 40-fold , respectively , whereas the endotoxin induced increase in response was not influenced by EPO . Positive_regulation TNF IL10 19181914 2033237 Iloprost induced expression , but suppressed CpG oligodeoxynucleotide- ( or imiquimod- ) *induced* [TNF-alpha] and IFN-alpha production in pDCs . Positive_regulation TNF IL10 19447494 2090730 Furthermore , neutralizing with anti-IL-10 antibody *enhanced* LPS induction of [TNFalpha] and TF expression in WT PMs . Positive_regulation TNF IL10 19922425 2240899 Our results suggest that PCERA-1 activates a G ( s ) protein coupled receptor , leading to elevation of cAMP , which acts via the PKA-CREB pathway to promote [TNF-alpha] suppression and *induction* in LPS stimulated macrophages . Positive_regulation TNF IL10 20159741 2208562 Tylosin at 500 mg/kg had no effect on [TNFalpha] or IL1beta production , but it *induced* production in healthy mice . Positive_regulation TNF IL10 20303596 2230507 Our results thus indicate that PKA mediated phosphorylation of CREB promotes [TNFalpha] suppression and *induction* , whereas the same phosphorylation event initiated by LPS and mediated by MSK1 is non-functional for transcriptional modulation . Positive_regulation TNF IL10 20587320 2285682 Treatment with astilbin decreases [TNF alpha] expression but *induces* expression in liver during warm ischemia-reperfusion injury . Positive_regulation TNF IL10 21113640 2407567 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL10 2113076 135514 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL10 21545584 2435330 TNF-a treatment *induced* a decrease in [TNF-a] , IL-12p40 and IL-10 mRNA levels in peritoneal cells following PPD stimulation while live M. tuberculosis caused an increase in TNF-a mRNA and a decrease in the mRNA expression . Positive_regulation TNF IL10 21809216 2484801 however , *had* no effect on IFN-? or [TNF-a] production or NK cell activatory receptor expression . Positive_regulation TNF IL10 21833021 2554577 The most common IL10 haplotype was associated with a significantly lower production and nonsignificantly *increased* [TNF-a] levels . Positive_regulation TNF IL10 21871585 2510352 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL10 21968712 2617075 Overexpression of transforming growth factor ( TGF ) -ß ( 1 ) , but not , *resulted* in suppressed lipopolysaccharide (LPS) induced production of [TNF-a] and downregulation of TLR4 expression in L. donovani infected macrophages . Positive_regulation TNF IL10 22103848 2514322 IL- 19 is upregulated in macrophages after infection and lessens inflammation by suppressing the production of [tumor necrosis factor-a] , IL-6 and IL-12 , but not by *inducing* . Positive_regulation TNF IL10 22219323 2544469 These observations have very important implications for our understanding as to how *regulates* [TNF-a] production at sites of chronic inflammation , such as the synovial tissue of patients with RA . Positive_regulation TNF IL10 22427640 2582793 Interestingly , production of IL-1a , IL-1ß , IL-6 , and [TNF-a] was strongly inhibited , but that of *enhanced* in LPS pretreated HSC/Treg cocultures . Positive_regulation TNF IL10 22870498 2641385 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL10 22995521 2689012 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL10 23107698 2695282 Furthermore , pre- and post treated FOs ( 0.1-100 µg/ml ) dose-dependently suppressed [TNF-a] , IL-1ß , IL-6 and NO production , and *induced* production in lipopolysaccharide (LPS) stimulated RAW264.7 cells without exerting cytotoxicity . Positive_regulation TNF IL10 23371318 2803611 Both splice variants were *induced* by [TNF-a] , IL-1ß and IFN-? , while induced c-FLIPL expression ; Positive_regulation TNF IL10 23586635 2772900 Moreover , pyriproxyfen induced higher titers of IgG2a and enhanced [tumor necrosis factor-alpha] and gamma-interferon responses whereas alum *induced* IgG1 with enhanced . Positive_regulation TNF IL10 23702712 2792419 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL10 23928481 2826601 Our previous study established that Poly-ICLC is the most potent individual maturation stimulus for human DCs as assessed by an upregulation of CD83 and CD86 , *induction* of interleukin-12 (IL-12) , [tumor necrosis factor (TNF)] , interferon gamma induced protein 10 (IP-10) , interleukmin 1 (IL-1) , and type I interferons ( IFN ) , and minimal production . Positive_regulation TNF IL10 2404745 128009 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL10 24165011 2879128 In this work we showed that Tat protein : i ) by its N-terminal domain induces production of both and TNF-a in a TLR4-MD2 dependent manner , ii ) interacts specifically with TLR4-MD2 and MD2 with high affinity but not with CD14 , iii ) *induces* in vivo [TNF-a] and IL-10 in a TLR4 dependent manner . Positive_regulation TNF IL10 2471522 111724 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL10 24749687 2943427 FICZ or ITE significantly inhibited the production of IL-1ß , IL-6 , IL-23 and [TNF-a] , but *induced* production by DCs derived from active BD patients and normal controls . Positive_regulation TNF IL10 3011946 59726 Tumor necrosis [factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL10 3260265 94469 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL10 3486936 60068 [Tumor necrosis factor] ( cachectin ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL10 3526909 62618 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL10 7536712 300174 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL10 7540642 310118 Seven-day cultured monocytes/macrophages showed ( 1 ) diminished [TNF-alpha] production in *response* to but not IL-4 ( 2 ) , diminished IL-1 beta production in response to both IL-4 and IL-10 , and compared with fresh monocytes ( 3 ) , diminished CD14 expression in response to IL-4 , and ( 4 ) a lesser increase in CD23 expression in response to IL-4 . Positive_regulation TNF IL10 7790026 313162 Because and IL-4 differentially *regulate* [TNF-alpha] and IL-1ra production by synovial fluid mononuclear cells , selective use of either IL-10 or IL-4 in the treatment of chronic inflammatory conditions will depend on whether TNF-alpha or IL-1 , respectively , is established as primarily responsible for the maintenance of the chronic inflammatory condition . Positive_regulation TNF IL10 7897226 300033 Blocking of by Ab *resulted* in a 52 % increase in lung vascular permeability , a 56 % increase in [TNF-alpha] activity in bronchoalveolar lavage fluids , and a 47 to 48 % increase in bronchoalveolar lavage neutrophils and lung myeloperoxidase content . Positive_regulation TNF IL10 7957562 278067 also *induced* down-regulation of surface p55 TNF-R on monocytes , and increased release of soluble p55 [TNF-R] . Positive_regulation TNF IL10 7957562 278069 , therefore , *reduces* the pro-inflammatory potential of TNF in three ways : by down regulating surface TNF-R expression whilst increasing production of soluble TNF-R and inhibiting the release of [TNF-alpha] itself . Positive_regulation TNF IL10 8097322 217604 We demonstrate that IFN-gamma production from SCID splenocytes is stimulated by interleukin (IL) 12 , tumor necrosis factor alpha (TNF-alpha) , and IL-2 but is inhibited by , IL-10 , IL-12 , and [TNF] are *induced* by heat killed Listeria monocytogenes ( hk-LM ) from SCID splenocytes and peritoneal macrophages . Positive_regulation TNF IL10 8132326 251492 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL10 8270873 247084 This protection against autoimmunity appeared to be due to an *induced* upregulation of endogenous [TNF-alpha] , since anti-IL-10 protected NZB/W F1 mice rapidly developed autoimmunity when neutralizing anti-TNF-alpha Abs were introduced at 30 wk along with the anti-IL-10 treatment . Positive_regulation TNF IL10 8333833 223711 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL10 8363277 229153 Thus , TGF-beta , but not IL-4 or , can *induce* resting human monocytes to produce [TNF] , IL-1 , and IL-6 . Positive_regulation TNF IL10 8592105 341937 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL10 8613550 353557 Whereas the in vivo regulatory effects of IL-1R appear to be limited to IL-1beta , *regulates* both IL-1beta and [TNF-alpha] in this model , reflected by a 48 % increase in BAL IL-1beta in rats treated with anti-IL-10 . Positive_regulation TNF IL10 8683105 370230 IL-12 and/or IL-6 can induce the expression of IL-10 by PHA stimulated T cells , whereas [TNF-alpha] *induces* production by monocytes . Positive_regulation TNF IL10 8704096 371120 suppressed LPS *induced* release of IL-alpha and [TNF-alpha] to approximately 50 % of control without affecting IL-6 release . Positive_regulation TNF IL10 8704096 371121 Our data demonstrate that IL-1 alpha and [TNF-alpha] release by AMs is down *regulated* by IL-4 , , and TGF-beta . Positive_regulation TNF IL10 8711645 371307 mRNA stability experiments indicated no acceleration in lipopolysaccharide induced [TNF-alpha] mRNA degradation in *response* to . Positive_regulation TNF IL10 8828740 385465 To investigate whether the upregulatory effect of on HIV expression in a model of latent HIV infection is *mediated* by induction of endogenous [tumour necrosis factor (TNF)-alpha] and TNF receptors (TNFR) . Positive_regulation TNF IL10 8871669 389623 In contrast , *increased* surface and soluble p75 [TNF] receptor levels on monocytes for approximately 40 h , which reflected an increase in receptor mRNA . Positive_regulation TNF IL10 8871669 389625 Addition of an Ab to IL-10 suggested that the stimulatory effects of LPS on p75 [TNF] receptor expression were *due* , at least in part , to LPS stimulation of production and that IL-4 acted , in part , by decreasing IL-10 production . Positive_regulation TNF IL10 8891438 391949 Finally , our data demonstrate that ethanol induced elevated M phi *contributes* to the decreased M phi [TNF-alpha] production seen after acute ethanol treatment . Positive_regulation TNF IL10 9079801 420590 Fixed , cytokine stimulated T cells induced monocytes to secrete [TNF-alpha] in a dose dependent manner , but did not *induce* secretion of , a potent endogenous down-regulator of TNF-alpha and other pro-inflammatory cytokines . Positive_regulation TNF IL10 9096593 422534 In controls , [TNF] , IL-1 , IL-6 , and *increase* within 3 hours after PH , whereas TGF-beta 1 is induced much later ( > 24 hours after PH ) . Positive_regulation TNF IL10 9160997 431826 Blocking of endogenous by neutralization with anti-IL-10 monoclonal antibody *resulted* in further augmented and prolonged secretion of [TNF-alpha] by both the fresh and frozen cells . Positive_regulation TNF IL10 9160997 431828 They also indicate that the [TNF-alpha] *induced* and then down-regulates the monocytes from further TNF-alpha secretion . Positive_regulation TNF IL10 9350293 460844 Since production of both IL-6 and [TNF-alpha] is *regulated* by , the enhancement of the production of these cytokines could reflect a defect in either IL-10 production or responsiveness . Positive_regulation TNF IL10 9369823 464065 Lipopolysaccharide plus stimulation *resulted* in a dose dependent decrease in [tumor necrosis factor-alpha] messenger ribonucleic production ( transcriptional regulation ) to 6000 ( 50/50 ) and 600 ( 50/100 ) molecules . Positive_regulation TNF IL10 9369823 464069 This study suggests that and transforming growth factor-beta can *regulate* [tumor necrosis factor-alpha] release from amniochorion under different conditions and by a different mechanism . Positive_regulation TNF IL10 9373262 464792 These data suggest that endogenous can *regulate* activated T-cell production of IFN-gamma and [TNF-alpha] via a paracrine negative feedback loop . Positive_regulation TNF IL10 9548401 498856 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL10 9551930 499114 Furthermore , neither the inhibition of monocyte [TNF-alpha] *induced* by nor the stimulation of soluble TNF receptor production was affected by inhibition of the p42/44 MAPK pathway , suggesting that this signaling event is not involved in either monocyte production of or anti-inflammatory responses to IL-10 . Positive_regulation TNF IL10 9605267 507589 The production of [tumor necrosis factor-alpha] and IL-1beta by cultured colonic tissues was inhibited by addition of IL-10 , and conversely , it was *enhanced* by . Positive_regulation TNF IL10 9657919 516879 IL-1beta and [TNF-alpha] synergistically *induced* IL-6 and GM-CSF and additively induced IL-8 and MCP-1 production , while IL-2 , , IFN-alpha , and IFN-gamma had little or no additional effects . Positive_regulation TNF IL10 9679667 520848 Transgenic expression of cytokines in beta-cells of non-diabetes-prone mice and NOD mice has suggested pathogenic roles for IFN alpha , IFN gamma , IL-2 and in insulin dependent diabetes mellitus ( IDDM ) development , and protective *roles* for IL-4 , IL-6 and [TNF alpha] . Positive_regulation TNF IL10 9767437 538644 SAg induced IL-2 , IFN-gamma and [TNF] were *detected* in both CD4+ and CD8+ T cells , whereas production of was restricted to CD4+ T cells . Positive_regulation TNF IL10 9833740 552027 *enhances* [tumor necrosis factor-alpha] activation of HIV-1 transcription in latently infected T cells . Positive_regulation TNF IL10 9833740 552030 Taken collectively , these data suggest that *enhances* suboptimal [TNF-alpha] activation of HIV-1 transcription in chronically infected T-cells at least in part through induction of endogenous TNF-alpha expression . Positive_regulation TNF IL10 9845572 553812 While peripheral leukocyte subpopulations only differed between the laparoscopic groups and the control group during the perioperative course , [TNFalpha] plasma levels were significantly decreased and plasma levels significantly *increased* in the CO2 group compared to the helium and control groups in the postoperative course . Positive_regulation TNF IL10 9920020 587851 The low dose of IL-12 *induced* [tumor necrosis factor alpha (TNFalpha)] production , whereas the high dose induced production of both and corticosterone and suppression of anticollagen antibody levels . Positive_regulation TNF IL11 10407498 629757 Furthermore , IL-1 alpha , TGF beta , and [TNF alpha] *induced* gene expression in VSMC . Positive_regulation TNF IL11 15517620 1328643 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL11 1598496 188829 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL11 21113640 2407568 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL11 2113076 135515 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL11 21871585 2510353 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL11 22870498 2641386 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL11 22995521 2689013 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL11 23702712 2792420 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL11 2404745 128010 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL11 2471522 111725 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL11 3011946 59727 [Tumor necrosis factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL11 3260265 94470 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL11 3486936 60069 Tumor necrosis factor ( [cachectin] ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL11 3526909 62619 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL11 7536712 300175 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL11 8132326 251493 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL11 8333833 223712 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL11 8592105 341938 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL11 8676079 369833 IL-1 , [TNF alpha] , PGE2 , parathyroid hormone (PTH) and 1 alpha,25-dihydroxyvitamin D3 ( 1 alpha,25 ( OH ) 2D3 ) similarly *induced* production of by osteoblasts , but IL-6 , IL-4 , and TGF beta did not . Positive_regulation TNF IL11 9548401 498857 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL12A 10427983 633050 When the antibodies were added to synovial cells from arthritic mice and bone marrow macrophages in vitro , anti-TNF diminished IL-12 production , but *had* no effect on [TNF] production . Positive_regulation TNF IL12A 10504438 648912 Both GM-CSF and [TNF-alpha] *induced* the migration of human Langerhans cells in vitro , whereas IL-1beta , IL-2 , IL-10 , , and IFN-gamma had no effect on Langerhans cell migration . Positive_regulation TNF IL12A 10546926 564677 added in vitro to lipopolysaccharide stimulated blood of filgrastim treated donors *restored* IFN-gamma and [TNF-alpha] release , suggesting that the anti-inflammatory effect of granulocyte colony stimulating factor is exercised through IL-12 suppression . Positive_regulation TNF IL12A 11129658 760009 However , and mycobacteria together *enhanced* [TNF-alpha] and NO release synergistically . Positive_regulation TNF IL12A 11129658 760012 Because and mycobacteria also released IFN-gamma from macrophages synergistically , and exogenous IFN-gamma with mycobacteria *enhanced* [TNF-alpha] and NO release synergistically , we examined the role of endogenous IFN-gamma in IL-12/mycobacteria stimulated macrophage activation . Positive_regulation TNF IL12A 11157054 780708 Initial comparisons indicated that [tumor necrosis factor] alpha induction of epithelial intercellular adhesion molecule 1 *required* sequential induction of ( p70 ) and interferon gamma , and unexpectedly localized IL-12 production to airway epithelial cells . Positive_regulation TNF IL12A 12391181 1007228 In contrast , *induced* FasL transcription to lead to FasL expression on the surfaces of nonadherent bone marrow cells , whereas [TNF-alpha] could not induce FasL on the cells . Positive_regulation TNF IL12A 12429722 1014979 dependent nuclear factor-kappaB activation *leads* to de novo synthesis and release of IL-8 and [TNF-alpha] in human neutrophils . Positive_regulation TNF IL12A 12429722 1014983 In addition *induces* the de novo synthesis and production of IL-8 and [tumor necrosis factor alpha (TNF-alpha)] in a calcium- and ROM dependent manner . Positive_regulation TNF IL12A 1358972 200435 This inhibitory effect is , at least in part , indirect , and depends on *induced* production of [TNF] . Positive_regulation TNF IL12A 15002060 1217162 is *involved* in regulation of IFNgamma and [TNFalpha] . Positive_regulation TNF IL12A 15100264 1239600 plus IL-18 rendered NK cells cytotoxic against Fas transfected target cells and *promoted* their production of IFN-gamma and [TNF-alpha] , which are both essential for sensitizing histamine producing cells to the Fas death pathway . Positive_regulation TNF IL12A 15498035 1325448 Furthermore , *augmented* IL-15 stimulated release of serine esterases as well as expression of perforin and FL by IELs , but not [TNF-alpha] . Positive_regulation TNF IL12A 15627978 1369421 The neutralization of either *induced* IFN-gamma or LPS induced [TNF-alpha] improved the survival of middle aged ( 25-week-old ) mice . Positive_regulation TNF IL12A 15683451 1370612 Polyriboinosinic polyribocytidylic acid ( Poly I:C ) + [tumour necrosis factor-alpha (TNF-alpha)] *induced* significant p70 secretion , which was increased after addition of a decoy IL-10 receptor . Positive_regulation TNF IL12A 16522779 1531511 Interestingly , we found that when weakly IL-12- and TNF-alpha inducing LAB and strong IL-12- and TNF-alpha inducing LAB were mixed , the weakly and TNF-alpha inducing LAB efficiently inhibited otherwise strong IL-12- and TNF-alpha inducing LAB , yet when weakly IL-12- and TNF-alpha inducing LAB were mixed with G- bacteria , they synergistically *induced* IL-12 and [TNF-alpha] . Positive_regulation TNF IL12A 16830103 1586769 Finally , isolated Kupffer cells produced [TNFalpha] in *response* to IL-23 , but not , suggesting that IL-23 may be the relevant initiator of the hepatic inflammatory response to ischemia/reperfusion . Positive_regulation TNF IL12A 18492334 1917104 Our study demonstrated that after stimulation of alveolar macrophages by Mce4E protein for 48 h , the expression of [TNF-alpha] was *induced* , with an enhanced IL-6 mRNA level ( P < 0.05 ) and no changes in expression in the macrophages . Positive_regulation TNF IL12A 19088276 2018615 We detected expression of interleukin (IL)-6 , [tumour necrosis factor (TNF)-alpha] , macrophage inflammatory protein (MIP)-1alpha , MIP-1beta , RANTES and IL-12p40 from 2 to 6 h post-infection , and these peaked by 15-24 h. Expression of these factors decreased 24-48 h post-infection , with the exception of TNF-alpha which remained high throughout the entire 72 h. Interestingly , while expression *increased* post-infection , bioactive IL-12p70 was not detected in the supernatants . Positive_regulation TNF IL12A 19410299 2128203 Zymosan *enhanced* dectin-1/TLR2/TLR4 expression and [TNF-alpha/IL-10] production in all of three types of cell , whereas p-beta-glucan increased dectin-1/TLR4 and production in AMs but inhibited IL-10 in mDCs . Positive_regulation TNF IL12A 20028205 2191987 A notable exception was the Gram positive Listeria monocytogenes , which *induced* very little , IFN-gamma , and [TNF] . Positive_regulation TNF IL12A 20738198 2313464 All tachyzoite and antigen preparations at high doses stimulated high levels of , interferon (IFN) -gamma , and tumor necrosis factor (TNF) -alpha , except for heat killed tachyzoites and sNcAg , which *induced* moderate level of IL-12 and very low levels of IFN-gamma and [TNF-alpha] . Positive_regulation TNF IL12A 20822815 2346064 On day 12 , [TNF-a] induction in monocyte derived macrophages and p40 *induction* in BAL macrophages infected with R. equi was significantly higher in foals treated with PPVO than in controls . Positive_regulation TNF IL12A 20974986 2348722 Sustained IL-18 signals resulted in IL-13 and GM-CSF production , whereas and IL-21 *induced* IL-10 and [TNF-a] . Positive_regulation TNF IL12A 21796650 2554485 LNCaP *enhance* IL-1ß , IL-23 , IL-6 , and [TNF-a] secretion by decreasing glucan dependent NADPH oxidase activity , whereas glucan increases production through NADPH oxidase unrelated mechanisms . Positive_regulation TNF IL12A 24683394 2931402 and IL-23 , by influencing the naïve lymphocytes T and stimulating their diversification towards Th1 and Th17 , also , indirectly , *cause* an increase in [TNF-a] and other cytokines production ( IL-2 , IFN-? , IL-17 , IL-10 , IL-22 ) . Positive_regulation TNF IL12A 7869050 296550 Northern blot and in situ hybridization analyses demonstrated that *induced* [TNF-alpha] expression and that LCMV infection synergized with IL-12 for induction of this factor . Positive_regulation TNF IL12A 7912999 262028 It was found that *induces* mRNA accumulation and production of GM-CSF and [TNF-alpha] from both T and NK cells and , as tested on NK cells only , induces M-CSF mRNA accumulation . Positive_regulation TNF IL12A 8097322 217605 We demonstrate that IFN-gamma production from SCID splenocytes is stimulated by , tumor necrosis factor alpha (TNF-alpha) , and IL-2 but is inhibited by IL-10 , IL-10 , IL-12 , and [TNF] are *induced* by heat killed Listeria monocytogenes ( hk-LM ) from SCID splenocytes and peritoneal macrophages . Positive_regulation TNF IL12A 8097934 217703 Furthermore , IL-4 induced a slight increase in the *stimulated* [TNF] production . Positive_regulation TNF IL12A 8102154 225848 also *induces* neonatal CD4 T cells to produce lymphotoxin but not IL-2 , [TNF-alpha] , or IL-4 . Positive_regulation TNF IL12A 8723796 373759 To understand the possible mechanisms for this suppression , ELISA assays were used to detect the release of interferon (IFN)-gamma and [tumor necrosis factor (TNF)-alpha] , which could potentially have been *induced* by from CD34 cells . Positive_regulation TNF IL12A 8723796 373763 The results suggest that the suppressive effects of on retroviral gene transduction are , at least in part , *mediated* by IL-12 induction of the release of [TNF-alpha] . Positive_regulation TNF IL12A 8876217 390346 Interferon gamma , IL-10 , and [tumor necrosis factor] could be *induced* throughout the treatment period by , indicating that repeated injections of IL-12 do not induce a state of tachyphylaxis . Positive_regulation TNF IL12A 8977306 403212 Furthermore , up-regulated TNF receptors on gammadelta T cells in vitro : [TNF-alpha] binding to its receptor *induced* CD25 expression on the gammadelta T cells in an autocrine or paracrine fashion , or perhaps both . Positive_regulation TNF IL12A 8992506 366183 Because *induces* production of [TNF-alpha] by certain cells of the immune system , we sought to determine whether UVB is an inducer of IL-12 gene expression in epidermal cells . Positive_regulation TNF IL12A 9336412 458167 Exogenous clearly *enhanced* IFN gamma and [TNF alpha] secretion . Positive_regulation TNF IL12A 9573060 501922 The number of bacteria in the macrophages infected with 103- and HK decreased progressively , whereas the 103+ numbers remained constant over 48 h . Interleukin 1beta (IL-1beta) , IL-6 , IL-10 , p40 , and [tumor necrosis factor alpha (TNF-alpha)] mRNA *induction* peaked at 4 h and returned to baseline between 12 and 48 h postinfection . Positive_regulation TNF IL12A 9711774 526989 The impaired ability of CB to produce and IL-15 in response to stimulation may *contribute* to the decrease in IFN-gamma , [TNF-alpha] production , NK and LAK activities . Positive_regulation TNF IL12A 9848688 554039 Whether these lipid A-common Re595 LPS preparations differed in activities , we investigated their effects on nitric oxide ( NO ) , [TNF-alpha] , IL-6 , and *induction* from murine macrophage cell line RAW 264.7 . Positive_regulation TNF IL12B 10427983 633051 When the antibodies were added to synovial cells from arthritic mice and bone marrow macrophages in vitro , anti-TNF diminished IL-12 production , but *had* no effect on [TNF] production . Positive_regulation TNF IL12B 10504438 648913 Both GM-CSF and [TNF-alpha] *induced* the migration of human Langerhans cells in vitro , whereas IL-1beta , IL-2 , IL-10 , , and IFN-gamma had no effect on Langerhans cell migration . Positive_regulation TNF IL12B 10546926 564678 added in vitro to lipopolysaccharide stimulated blood of filgrastim treated donors *restored* IFN-gamma and [TNF-alpha] release , suggesting that the anti-inflammatory effect of granulocyte colony stimulating factor is exercised through IL-12 suppression . Positive_regulation TNF IL12B 11129658 760010 However , and mycobacteria together *enhanced* [TNF-alpha] and NO release synergistically . Positive_regulation TNF IL12B 11129658 760013 Because and mycobacteria also released IFN-gamma from macrophages synergistically , and exogenous IFN-gamma with mycobacteria *enhanced* [TNF-alpha] and NO release synergistically , we examined the role of endogenous IFN-gamma in IL-12/mycobacteria stimulated macrophage activation . Positive_regulation TNF IL12B 11157054 780709 Initial comparisons indicated that [tumor necrosis factor] alpha induction of epithelial intercellular adhesion molecule 1 *required* sequential induction of ( p70 ) and interferon gamma , and unexpectedly localized IL-12 production to airway epithelial cells . Positive_regulation TNF IL12B 12391181 1007229 In contrast , *induced* FasL transcription to lead to FasL expression on the surfaces of nonadherent bone marrow cells , whereas [TNF-alpha] could not induce FasL on the cells . Positive_regulation TNF IL12B 12429722 1014980 dependent nuclear factor-kappaB activation *leads* to de novo synthesis and release of IL-8 and [TNF-alpha] in human neutrophils . Positive_regulation TNF IL12B 12429722 1014984 In addition *induces* the de novo synthesis and production of IL-8 and [tumor necrosis factor alpha (TNF-alpha)] in a calcium- and ROM dependent manner . Positive_regulation TNF IL12B 1358972 200436 This inhibitory effect is , at least in part , indirect , and depends on *induced* production of [TNF] . Positive_regulation TNF IL12B 15002060 1217163 is *involved* in regulation of IFNgamma and [TNFalpha] . Positive_regulation TNF IL12B 15100264 1239601 plus IL-18 rendered NK cells cytotoxic against Fas transfected target cells and *promoted* their production of IFN-gamma and [TNF-alpha] , which are both essential for sensitizing histamine producing cells to the Fas death pathway . Positive_regulation TNF IL12B 15498035 1325449 Furthermore , *augmented* IL-15 stimulated release of serine esterases as well as expression of perforin and FL by IELs , but not [TNF-alpha] . Positive_regulation TNF IL12B 15627978 1369422 The neutralization of either *induced* IFN-gamma or LPS induced [TNF-alpha] improved the survival of middle aged ( 25-week-old ) mice . Positive_regulation TNF IL12B 15683451 1370613 Polyriboinosinic polyribocytidylic acid ( Poly I:C ) + [tumour necrosis factor-alpha (TNF-alpha)] *induced* significant p70 secretion , which was increased after addition of a decoy IL-10 receptor . Positive_regulation TNF IL12B 16522779 1531512 Interestingly , we found that when weakly IL-12- and TNF-alpha inducing LAB and strong IL-12- and TNF-alpha inducing LAB were mixed , the weakly IL-12- and TNF-alpha inducing LAB efficiently inhibited otherwise strong and TNF-alpha inducing LAB , yet when weakly IL-12- and TNF-alpha inducing LAB were mixed with G- bacteria , they synergistically *induced* IL-12 and [TNF-alpha] . Positive_regulation TNF IL12B 16549049 1537877 also *promoted* the production of Th1 cytokines such as IFN-gamma , IL-12 and [TNF-alpha] . Positive_regulation TNF IL12B 16830103 1586770 Finally , isolated Kupffer cells produced [TNFalpha] in *response* to IL-23 , but not , suggesting that IL-23 may be the relevant initiator of the hepatic inflammatory response to ischemia/reperfusion . Positive_regulation TNF IL12B 17619881 1815990 [TNF-alpha] *induced* MIP-3alpha but not production in cultured synovial cells from RA patients . Positive_regulation TNF IL12B 17641010 1771210 The mature DC ( CD83 ( + ) CD70 ( + ) HLA-DR ( high ) CD14 ( low ) ) expressed high levels of mRNA for IL-6 , IL-15 , and , *induced* naive CD4 T cells to produce IFN-gamma and [TNF-alpha] , and stimulated resting CD4 T cells to secret IL-17 . Positive_regulation TNF IL12B 18492334 1917105 Our study demonstrated that after stimulation of alveolar macrophages by Mce4E protein for 48 h , the expression of [TNF-alpha] was *induced* , with an enhanced IL-6 mRNA level ( P < 0.05 ) and no changes in expression in the macrophages . Positive_regulation TNF IL12B 19088276 2018616 We detected expression of interleukin (IL)-6 , [tumour necrosis factor (TNF)-alpha] , macrophage inflammatory protein (MIP)-1alpha , MIP-1beta , RANTES and IL-12p40 from 2 to 6 h post-infection , and these peaked by 15-24 h. Expression of these factors decreased 24-48 h post-infection , with the exception of TNF-alpha which remained high throughout the entire 72 h. Interestingly , while expression *increased* post-infection , bioactive IL-12p70 was not detected in the supernatants . Positive_regulation TNF IL12B 19410299 2128204 Zymosan *enhanced* dectin-1/TLR2/TLR4 expression and [TNF-alpha/IL-10] production in all of three types of cell , whereas p-beta-glucan increased dectin-1/TLR4 and production in AMs but inhibited IL-10 in mDCs . Positive_regulation TNF IL12B 20028205 2191988 A notable exception was the Gram positive Listeria monocytogenes , which *induced* very little , IFN-gamma , and [TNF] . Positive_regulation TNF IL12B 20738198 2313465 All tachyzoite and antigen preparations at high doses stimulated high levels of , interferon (IFN) -gamma , and tumor necrosis factor (TNF) -alpha , except for heat killed tachyzoites and sNcAg , which *induced* moderate level of IL-12 and very low levels of IFN-gamma and [TNF-alpha] . Positive_regulation TNF IL12B 20822815 2346065 On day 12 , [TNF-a] induction in monocyte derived macrophages and p40 *induction* in BAL macrophages infected with R. equi was significantly higher in foals treated with PPVO than in controls . Positive_regulation TNF IL12B 20974986 2348723 Sustained IL-18 signals resulted in IL-13 and GM-CSF production , whereas and IL-21 *induced* IL-10 and [TNF-a] . Positive_regulation TNF IL12B 21796650 2554486 LNCaP *enhance* IL-1ß , IL-23 , IL-6 , and [TNF-a] secretion by decreasing glucan dependent NADPH oxidase activity , whereas glucan increases production through NADPH oxidase unrelated mechanisms . Positive_regulation TNF IL12B 24683394 2931403 and IL-23 , by influencing the naïve lymphocytes T and stimulating their diversification towards Th1 and Th17 , also , indirectly , *cause* an increase in [TNF-a] and other cytokines production ( IL-2 , IFN-? , IL-17 , IL-10 , IL-22 ) . Positive_regulation TNF IL12B 7869050 296551 Northern blot and in situ hybridization analyses demonstrated that *induced* [TNF-alpha] expression and that LCMV infection synergized with IL-12 for induction of this factor . Positive_regulation TNF IL12B 7912999 262029 It was found that *induces* mRNA accumulation and production of GM-CSF and [TNF-alpha] from both T and NK cells and , as tested on NK cells only , induces M-CSF mRNA accumulation . Positive_regulation TNF IL12B 8097322 217606 We demonstrate that IFN-gamma production from SCID splenocytes is stimulated by , tumor necrosis factor alpha (TNF-alpha) , and IL-2 but is inhibited by IL-10 , IL-10 , IL-12 , and [TNF] are *induced* by heat killed Listeria monocytogenes ( hk-LM ) from SCID splenocytes and peritoneal macrophages . Positive_regulation TNF IL12B 8097934 217704 Furthermore , IL-4 induced a slight increase in the *stimulated* [TNF] production . Positive_regulation TNF IL12B 8102154 225849 also *induces* neonatal CD4 T cells to produce lymphotoxin but not IL-2 , [TNF-alpha] , or IL-4 . Positive_regulation TNF IL12B 8723796 373760 To understand the possible mechanisms for this suppression , ELISA assays were used to detect the release of interferon (IFN)-gamma and [tumor necrosis factor (TNF)-alpha] , which could potentially have been *induced* by from CD34 cells . Positive_regulation TNF IL12B 8723796 373764 The results suggest that the suppressive effects of IL-12 on retroviral gene transduction are , at least in part , mediated by *induction* of the release of [TNF-alpha] . Positive_regulation TNF IL12B 8876217 390347 Interferon gamma , IL-10 , and [tumor necrosis factor] could be *induced* throughout the treatment period by , indicating that repeated injections of IL-12 do not induce a state of tachyphylaxis . Positive_regulation TNF IL12B 8977306 403213 Furthermore , up-regulated TNF receptors on gammadelta T cells in vitro : [TNF-alpha] binding to its receptor *induced* CD25 expression on the gammadelta T cells in an autocrine or paracrine fashion , or perhaps both . Positive_regulation TNF IL12B 8992506 366184 Because *induces* production of [TNF-alpha] by certain cells of the immune system , we sought to determine whether UVB is an inducer of IL-12 gene expression in epidermal cells . Positive_regulation TNF IL12B 9336412 458168 Exogenous clearly *enhanced* IFN gamma and [TNF alpha] secretion . Positive_regulation TNF IL12B 9573060 501923 The number of bacteria in the macrophages infected with 103- and HK decreased progressively , whereas the 103+ numbers remained constant over 48 h . Interleukin 1beta (IL-1beta) , IL-6 , IL-10 , p40 , and [tumor necrosis factor alpha (TNF-alpha)] mRNA *induction* peaked at 4 h and returned to baseline between 12 and 48 h postinfection . Positive_regulation TNF IL12B 9711774 526990 The impaired ability of CB to produce and IL-15 in response to stimulation may *contribute* to the decrease in IFN-gamma , [TNF-alpha] production , NK and LAK activities . Positive_regulation TNF IL12B 9848688 554040 Whether these lipid A-common Re595 LPS preparations differed in activities , we investigated their effects on nitric oxide ( NO ) , [TNF-alpha] , IL-6 , and *induction* from murine macrophage cell line RAW 264.7 . Positive_regulation TNF IL13 11880312 919374 U-0126 also inhibited , and [TNF-alpha] *induced* mRNA expression . Positive_regulation TNF IL13 12244147 990520 In contrast , the production of IL-12 p70 , but not IL-10 and [TNF] , induced by microbial products was *enhanced* only by IL-4 , not by or Y119D , a selective type II IL-4R agonist , in vitro and in vivo . Positive_regulation TNF IL13 15517620 1328644 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL13 1598496 188830 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL13 17455319 1865861 In vitro studies further demonstrate that both exogenous and T cell derived can *regulate* [TNFalpha] production by macrophages following lipopolysaccharide stimulation . Positive_regulation TNF IL13 17617590 1769627 IL-4 and negatively *regulate* [TNF-alpha-] and IFN-gamma induced beta-defensin expression through STAT-6 , suppressor of cytokine signaling (SOCS)-1 , and SOCS-3 . Positive_regulation TNF IL13 18554706 1959086 [TNF-alpha] , elicited either by allergen exposure or pulmonary overexpression , *induced* SP-D , , and mononuclear cell influx in the lung . Positive_regulation TNF IL13 21113640 2407569 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL13 2113076 135516 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL13 21871585 2510354 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL13 21893119 2506439 Conversely , activation of caspase by exogenous [TNF-a] *required* , TWEAK , and Fn14 . Positive_regulation TNF IL13 22870498 2641387 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL13 22995521 2689014 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL13 23702712 2792421 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL13 2404745 128011 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL13 2471522 111726 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL13 24879793 2945826 IL-13Ra2 expression can be *induced* in lung fibroblasts by IL-4 or via a STAT6 dependent mechanism , or by [TNF-a] via a STAT6 independent mechanism . Positive_regulation TNF IL13 3011946 59728 Tumor necrosis [factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL13 3260265 94471 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL13 3486936 60070 [Tumor necrosis factor] ( cachectin ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL13 3526909 62620 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL13 7536712 300176 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL13 8132326 251494 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL13 8333833 223713 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL13 8592105 341939 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL13 9162077 431916 Whereas LPS induced TNF-alpha production is strongly suppressed by both cytokines , [TNF-alpha] mRNA accumulation is not significantly affected , indicating that IL-4 and *induce* a translational repression of TNF-alpha mRNA . Positive_regulation TNF IL13 9548401 498858 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL13 9916735 587521 In addition , *caused* significant increases in bronchoalveolar lavage levels of [TNF-alpha] , macrophage inflammatory protein-2 , and cytokine-inducible neutrophil chemoattractant but no changes in lung vascular ICAM-1 . Positive_regulation TNF IL13RA2 18451175 1902916 Furthermore , acting on prior studies showing that expression is *induced* ( in part ) by [tumor necrosis factor-alpha (TNF-alpha)] , we show that receptor expression and TGF-beta(1) production is inhibited by administration of a TNF-alpha neutralizing substance , TNF-alpha R-Fc ( etanercept ) . Positive_regulation TNF IL15 10453029 637890 Regulation of *stimulated* [TNF-alpha] production by rolipram . Positive_regulation TNF IL15 10453029 637891 Pretreatment of T cells with rolipram or cAMP analogues inhibited the *stimulated* increases in proliferation , expression of cell surface molecules CD69 , ICAM-1 , and LFA-1 , and release of [TNF-alpha] from macrophages . Positive_regulation TNF IL15 10725717 677631 Moreover , lamina propria T cells ( LP-T ) from IBD patients were more responsive to IL-15 as compared with controls , and alone without a primary T cell stimulus *induced* IFN-gamma and [TNF] production by isolated IBD LP-T cells , especially by LP-T cells from patients with Crohn 's disease . Positive_regulation TNF IL15 11219394 763949 IL-1beta and [TNF-alpha] also *induce* in fibroblast like synoviocytes , which induces the production of IL-17 which in turn potentiates IL-1beta and TNF-alpha production in monocyte-macrophages . Positive_regulation TNF IL15 12928391 1132000 strongly *induces* [TNF-alpha] production in SOCS1-deficient CD8+ T cells , indicating that SOCS1 is also a critical regulator of CD8+ T cell activation by IL-15 . Positive_regulation TNF IL15 14617758 1168540 This antibody effectively blocked *induced* T cell proliferation and monocyte [TNF-alpha] release in vitro . Positive_regulation TNF IL15 15498035 1325450 Furthermore , IL-12 augmented *stimulated* release of serine esterases as well as expression of perforin and FL by IELs , but not [TNF-alpha] . Positive_regulation TNF IL15 15517620 1328645 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL15 15614044 1357448 also *increased* overall perforin and [tumor necrosis factor-alpha] expression and more prominently in CTLs . Positive_regulation TNF IL15 15735428 1378425 , in the absence of Io + PMA , did not *induce* the expression of IFN-gamma , [TNF-alpha] , or IL-2R alpha . Positive_regulation TNF IL15 1598496 188831 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL15 16427155 1547553 The results show that p17 , while ineffective on resting monocytes , exerts an inflammatory action on IL-4 mediated inhibition of [TNF-alpha] and IFN-gamma production *induced* by stimulation . Positive_regulation TNF IL15 17045026 1635681 also *increased* the production of IFN-gamma and [TNF-alpha] in the healthy controls [ ( 211 +/- 57 ) ng/L to ( 343 +/- 108 ) ng/L , ( 1,203 +/- 390 ) ng/L to ( 1,468 +/- 235 ) ng/L , respectively ] , and decreased the production of IL-4 and IL-10 [ ( 43 +/- 13 ) ng/L to ( 36 +/- 8 ) ng/L , ( 135 +/- 37 ) ng/L to ( 90 +/- 35 ) ng/L , respectively ] . Positive_regulation TNF IL15 17641010 1771211 The mature DC ( CD83 ( + ) CD70 ( + ) HLA-DR ( high ) CD14 ( low ) ) expressed high levels of mRNA for IL-6 , , and IL-23 , *induced* naive CD4 T cells to produce IFN-gamma and [TNF-alpha] , and stimulated resting CD4 T cells to secret IL-17 . Positive_regulation TNF IL15 18782269 1963274 In contrast , *increased* [TNF-alpha] transcription in these cells . Positive_regulation TNF IL15 18957484 2127636 Treatment of PBL with leflunomide , cyclosporin A and FK-506 inhibited the *induced* expression of both CD54 and CD69 by PBL , as well as [TNF] production in co-cultures of activated PBL and THP-1 cells . Positive_regulation TNF IL15 19559672 2110577 [TNF-alpha] also increased IFN-gamma production in NK cells in the *presence* of . Positive_regulation TNF IL15 20062995 2225445 [TNF-alpha] *induced* production of IP-10 , but not in cultured synovial cells from RA patients . Positive_regulation TNF IL15 21113640 2407570 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL15 2113076 135517 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL15 21871585 2510355 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL15 22262794 2551417 The production of interferon ( IFN ) ? and [tumor necrosis factor (TNF)] a by NK cells in responding to influenza was further *enhanced* by . Positive_regulation TNF IL15 22870498 2641388 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL15 22995521 2689015 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL15 23702712 2792422 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL15 24019554 2846087 Epidermal IL-15Ra was shed by keratinocytes via proteolytic cleavage by matrix metalloproteinases upon stimulation with proinflammatory cytokines to counteract *induced* proliferation of IL-17 ( + ) aß and ?d T cells and production of [TNF] , IL-23 , IL-17 , and IL-22 during skin inflammation . Positive_regulation TNF IL15 2404745 128012 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL15 2471522 111727 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL15 3011946 59729 [Tumor necrosis factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL15 3260265 94472 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL15 3486936 60071 Tumor necrosis factor ( [cachectin] ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL15 3526909 62621 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL15 7536712 300177 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL15 8132326 251495 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL15 8333833 223714 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL15 8592105 341940 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL15 9018238 412192 We now report that can *induce* [TNF-alpha] production in RA through activation of synovial T cells . Positive_regulation TNF IL15 9018238 412194 also *induced* direct [TNF-alpha] production by synovial T cells . Positive_regulation TNF IL15 9300718 453886 The *stimulation* ( but not the suppression ) of [TNF-alpha] production by required the ( IL-2/IL-15 ) receptor beta chain , as demonstrated by receptor subunit blocking studies and lack of stimulation of Mphi from IL-2Rbeta-deficient mice . Positive_regulation TNF IL15 9373262 464783 significantly *enhanced* T-cell production of interferon-gamma (IFN-gamma) , [tumor necrosis factor-alpha (TNF-alpha)] , and IL-10 . Positive_regulation TNF IL15 9376592 465506 also significantly *induced* interferon-gamma (IFN-gamma) and [tumor necrosis factor-alpha (TNF-alpha)] protein production ( days 1 , 3 , and 6 , P < .05 , n = 3 ) in CB MNCs . Positive_regulation TNF IL15 9376592 465512 However , exogenous *enhanced* IFN-gamma and [TNF-alpha] production and NK and LAK cytotoxicities in CB MNCs . Positive_regulation TNF IL15 9548401 498859 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL15 9711774 526991 The impaired ability of CB to produce IL-12 and in response to stimulation may *contribute* to the decrease in IFN-gamma , [TNF-alpha] production , NK and LAK activities . Positive_regulation TNF IL15 9933419 589334 MTX reduced spontaneous and *induced* [tumour necrosis factor (TNF)] production by splenic T cells but not by macrophages from healthy mice in vitro in a dose dependent manner . Positive_regulation TNF IL15 9933419 589336 Thus , MTX specifically modulates spontaneous and *induced* [TNF-alpha] production in mice and prevents experimental murine CIA . Positive_regulation TNF IL16 11171821 784101 Moreover , *activates* expression and production of proinflammatory cytokines such as IL-1beta , IL-6 , IL-15 , and [tumour necrosis factor alpha (TNF-alpha)] in human monocytes . Positive_regulation TNF IL16 15517620 1328646 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL16 1598496 188832 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL16 21113640 2407571 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL16 2113076 135518 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL16 21871585 2510356 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL16 22870498 2641389 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL16 22995521 2689016 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL16 23702712 2792423 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL16 2404745 128013 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL16 2471522 111728 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL16 3011946 59730 Tumor necrosis [factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL16 3260265 94473 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL16 3486936 60072 [Tumor necrosis factor] ( cachectin ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL16 3526909 62622 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL16 7536712 300178 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL16 8132326 251496 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL16 8333833 223715 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL16 8592105 341941 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL16 9548401 498860 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL17A 11588011 866560 Moreover , overexpression of in the pulmonary compartment using a recombinant adenovirus encoding murine IL-17 ( AdIL-17 ) *resulted* in the local induction of [tumor necrosis factor-alpha] , IL-1beta , macrophage inflammatory protein-2 , and granulocyte colony stimulating factor ( G-CSF ) ; Positive_regulation TNF IL17A 12421973 1013799 also *enhanced* [TNF-alpha-] and IFN-gamma induced secretion of macrophage-inflammatory proteins 1alpha and 3alpha , while inhibiting the induced secretion of RANTES . Positive_regulation TNF IL17A 15149634 1248412 IL-1 and [TNF-alpha] *induced* most of these transcription factors while had a weak effect . Positive_regulation TNF IL17A 15229940 1269069 Recombinant upregulated synoviocyte COX-2 expression and *enhanced* [TNF-a] stimulated synoviocyte COX-2 expression . Positive_regulation TNF IL17A 17214584 1664076 At the same time , PGE2 suppresses osteoclastogenesis by inhibiting M-CSF expression of fibroblast-like synoviocytes as well as both IL-17 and *induced* [TNF-alpha] expression of macrophages . Positive_regulation TNF IL17A 17384030 1715797 MMPs , IL-1 , and [TNF] are *regulated* by in periodontitis . Positive_regulation TNF IL17A 17384030 1715803 was less potent as a direct MMP inducer than IL-1beta and TNF-alpha , but it *induced* IL-1beta and [TNF-alpha] production from macrophages , and IL-6 and IL-8 from gingival fibroblasts . Positive_regulation TNF IL17A 17982105 1821079 In vitro , , IL-17B , IL-17C , and IL-17F *induced* [TNF-alpha] production in mouse peritoneal exudate cells . Positive_regulation TNF IL17A 18477039 1921618 stimulation also *resulted* in the production of [TNF-alpha] . Positive_regulation TNF IL17A 18512248 1945205 *enhanced* the IL-8 and [TNF-alpha] response of the epithelial cell line to lipopolysaccharide (LPS) in vitro . Positive_regulation TNF IL17A 18786965 1976020 On the other hand , [TNF-alpha] and IL-17 did not *induce* RANKL expression , although TNF-alpha , or IL-1beta stimulated cell growth and IL-6 production . Positive_regulation TNF IL17A 19014637 2006639 In contrast , TNF promoted secretion of MMPs but did not *augment* [TNF] , indicating that IL-17 acts via an independent mechanism . Positive_regulation TNF IL17A 19356801 2157131 RT-PCR analysis of mRNA transcripts of diabetogenic cytokines revealed that the expression of [TNF-alpha] , and IFN-gamma was significantly *enhanced* in pancreatic lymph nodes by day 10 after diabetes induction in ST2-deficient mice in comparison with wild type BALB/c mice while was detected only in ST2 ( -/- ) mice by day 21 . Positive_regulation TNF IL17A 19815670 2164501 IL-17A protein was detected in approximately 40 % of the supernatants and blockade , in IL-17A producing cultures , *resulted* in a small but significant inhibition of [TNF-alpha] ( 38 % ) , IL-1beta ( 23 % ) and IL-6 ( 22 % ) . Positive_regulation TNF IL17A 20220144 2249421 We demonstrate here that NGAL is strongly induced by stimulation with [TNF-alpha] in the *presence* of , a pro-inflammatory cytokine produced by the newly discovered subset of CD4 ( + ) T helper cells , T ( H ) -17 . Positive_regulation TNF IL17A 20630498 2304573 The expression of COX-2 , IL-1alpha , IL-6 , IL-8 , IL-11 , and [TNF-alpha] , as well as PGE ( 2 ) production increased in the *presence* of , whereas COX-1 expression did not change . Positive_regulation TNF IL17A 20936708 2357121 Exogenous *stimulated* the expression and production of inflammatory cytokines ( [TNF-a] , IL-6 , and IL-1ß ) and chemokine IL-8 by HLECs . Positive_regulation TNF IL17A 21993883 2533113 also *enhanced* [TNF-a-] or IL-1ß mediated G-CSF secretion from cells . Positive_regulation TNF IL17A 22136309 2557845 In terms of local cytokine network in the skin , dramatically *induced* IL-1ß , IL-6 , and [TNF-a] production in skin-resident cells such as keratinocytes and fibroblasts . Positive_regulation TNF IL17A 22976954 2693594 IFN-? produced by CD4 ( + ) T cells *induced* [TNF-a] production in macrophages , whereas secreted by ?d T cells led to neutrophil recruitment . Positive_regulation TNF IL17A 23240747 2708686 In vitro inhibition tests of sera from vaccine immunized mice were performed using *induced* IL-6 production by NIH 3T3 cells and IL-17 induced [TNF] production by macrophages . Positive_regulation TNF IL17A 23240747 2708688 Furthermore , in vitro study revealed that serum IL-17-specific IgG from vaccine immunized mice significantly enhanced *induced* IL-6 production and IL-17 induced [TNF] production dose-dependently . Positive_regulation TNF IL17A 23331180 2769720 Elevated IL-17 levels and *induced* IFN-? and [TNF-a] overproduction may be involved in the pathogenesis of lower risk MDS . Positive_regulation TNF IL17A 23590864 2838106 Furthermore , it was reported from our laboratory that *enhances* the production of [TNF-a] by the Kupffer cell , suggesting that IL-17A may play a role in liver regeneration . Positive_regulation TNF IL17A 23840239 2809053 Baicalin also blocked *induced* intercellular adhesion molecule 1 , vascular cell adhesion molecule 1 , IL-6 , and [tumor necrosis factor-alpha] mRNA expression in cultured synoviocytes . Positive_regulation TNF IL17A 24247374 2879609 Pharmacological inhibitors of p38 and ERK1/2 partly attenuated *induced* [TNF-a] , IL-1ß , and IL-6 production . Positive_regulation TNF IL17A 9531313 496845 IL-10 exerted a significant suppressive effect on *induced* [TNF-alpha] release ( 99 % , p < 0.02 ) , while the inhibitory effects of IL-4 , IL-13 , and TGF-beta2 on TNF-alpha secretion were partial ( 48 , 10 , and 23 % , respectively ) . Positive_regulation TNF IL17C 17982105 1821080 In vitro , IL-17A , IL-17B , , and IL-17F *induced* [TNF-alpha] production in mouse peritoneal exudate cells . Positive_regulation TNF IL17D 20301193 2238029 These synergistic effects on the up-regulation of ICAM-1 and IL-6 were partially due to the elevated expression of [TNF-alpha] receptor ( p55TNFR ) *induced* by . Positive_regulation TNF IL17D 20971923 2348630 In this study , we found that production is *induced* by [TNF-a] in human macrophages ( MF ) and investigated the effects of IL-27 on the responses of primary human MF to the endogenous inflammatory cytokines TNF-a and IL-1 . Positive_regulation TNF IL17D 21506940 2434887 In conclusion , our data suggest that elevated IL-27 and *induced* [TNF-a] and IFN-? overproduction might be involved in the pathogenesis of AA . Positive_regulation TNF IL17D 23049843 2684913 Furthermore , we observed downregulation of *induced* IL-6 , [TNF-a] , and IL-10 expression in HIV positive subjects . Positive_regulation TNF IL17F 17982105 1821078 In vitro , IL-17A , IL-17B , IL-17C , and *induced* [TNF-alpha] production in mouse peritoneal exudate cells . Positive_regulation TNF IL17F 18411338 1907780 We show that like IL-17 , regulates proinflammatory gene expression in vitro , and this *requires* IL-17 receptor A , [tumor necrosis factor] receptor associated factor 6 , and Act1 . Positive_regulation TNF IL18 10525448 654046 *induces* gene expression and synthesis of [tumor necrosis factor (TNF)] , IL-1 , Fas ligand , and several chemokines . Positive_regulation TNF IL18 10562301 567019 independently promoted GM-CSF and nitric oxide production , and it *induced* significant [TNF-alpha] synthesis by CD14 ( + ) macrophages in synovial cultures ; Positive_regulation TNF IL18 11086098 751000 Apart from Th1 immune-stimulatory activity , *induces* the production of proinflammatory cytokines such as [TNF-alpha] and IL-1 in vitro . Positive_regulation TNF IL18 11520077 851920 On the other hand , anti-ICAM-1 and anti-LFA-1 Abs inhibited *induced* production of three cytokines , IL-12 , IFN-gamma , and [TNF-alpha] , by 60 and 40 % , respectively . Positive_regulation TNF IL18 11748266 889592 In vitro , neutralizing *resulted* in a significant inhibition of [TNF-alpha] , IL-6 , and IFN-gamma secretion by macrophages . Positive_regulation TNF IL18 11752121 898678 In the present study , we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12 , IFN-gamma , and [TNF-alpha] *induced* by were concentration dependently inhibited by coexisting histamine , whereas IL-18 inhibited IL-10 production was reversed by the same concentrations of histamine . Positive_regulation TNF IL18 11859116 914755 In contrast , IL-1alpha , IL-1beta , [TNF-alpha] , IFN-gamma-inducible protein-10 , and Th2 cytokines such as IL-4 and IL-10 did not *induce* . Positive_regulation TNF IL18 11890646 894230 *induces* gene expression and synthesis of [tumour necrosis factor (TNF)] , IL1 , Fas ligand , several chemokines , and vascular adhesion molecules . Positive_regulation TNF IL18 12023376 943786 Because disease severity was increased in IFN-gamma ( -/- ) vs IL-18 neutralized mice , and since also *induces* production of [TNF] , we tested for TNF-alpha in both groups . Positive_regulation TNF IL18 12056480 951854 In the ileum , IFN-gamma , [TNF-alpha] , and IL-1beta were *induced* mainly by the virulent strain , whereas was induced in highest quantity by non-virulent Salmonella . Positive_regulation TNF IL18 12538816 1050399 In the same manner , salbutanol and terbutaline as well as norepinephrine , epinephrine , and isoproterenol regulated the *induced* cytokine production , including IL-12 , [tumor necrosis factor-alpha] or interferon-gamma through the stimulation of beta 2-AR. Together with the previous finding that ICAM-1/lymphocyte function associated antigen-1 interaction plays a crucial role in the IL-18 initiated cytokine network , the present study strongly suggested that the stimulation of beta 2-AR inhibited the IL-18 activated cytokine cascade through the inhibitory effect on ICAM-1 expression , contributing to finding a new method for clinical treatment . Positive_regulation TNF IL18 12571421 1029566 In addition , also *upregulates* the production of proinflammatory cytokines such as IL-1 and [tumor necrosis factor-alpha] . Positive_regulation TNF IL18 14872485 1208428 dose-dependently *enhanced* the production of IL-1beta and [TNFalpha] , but not IL-10 , by monocytes following contact with RA synovial T cells or PHA prestimulated T cells . Positive_regulation TNF IL18 15100264 1239602 IL-12 plus rendered NK cells cytotoxic against Fas transfected target cells and *promoted* their production of IFN-gamma and [TNF-alpha] , which are both essential for sensitizing histamine producing cells to the Fas death pathway . Positive_regulation TNF IL18 15207779 1261682 Previously , we reported that [tumor necrosis factor (TNF)-alpha] production could be detected in human peripheral blood mononuclear cells ( PBMCs ) treated with relatively low concentration of LPS ( 1 ng/ml ) , but that same concentration of LPS could not *induce* production . Positive_regulation TNF IL18 15517620 1328647 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL18 15949134 1421201 is a pro-inflammatory cytokine of the IL-1 family and it *induces* IL-1 , [TNF] , and IL-6 , all of which are endogenous pyrogens . Positive_regulation TNF IL18 1598496 188833 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL18 16464907 1567562 [TNF] *induced* gene expression in muscle tissue , but not in adipose tissue , whereas IL-6 infusion had no effect on IL-18 gene expression in either tissue . Positive_regulation TNF IL18 17032165 1630713 The cumulative effects of define a novel role for this cytokine as a molecular survival switch that functions to both decrease cell death through inhibition of the mitochondrial apoptotic pathway and *enhance* [TNF] induction of prosurvival factors . Positive_regulation TNF IL18 17310143 1711501 In the present study , we examined the effect of adenosine on the *induced* up-regulation of ICAM-1 on human monocytes and production of IL-12 , IFN-gamma and [TNF-alpha] by PBMC . Positive_regulation TNF IL18 19285156 2127933 In CLE but not normal keratinocytes strongly *induces* [TNFalpha] release , which then results in apoptosis . Positive_regulation TNF IL18 19761760 2147365 The dsRNA-mimetic poly ( I:C ) and *synergize* for IFNgamma and [TNFalpha] expression . Positive_regulation TNF IL18 19761760 2147368 The stunning synergism inherent to *induced* [TNFalpha/IFNgamma] detected herein may contribute to this pathological phenomenon . Positive_regulation TNF IL18 19907017 2209845 In turn , [TNF-alpha] stimulation disrupted the association of IL-18 with F-actin , *induced* a FRET+ interaction of with lipid rafts , and elicited IL-18 release . Positive_regulation TNF IL18 20056085 2193668 [ N-acetylcysteine antagonizes the *induced* expression of [TNF-alpha] and IL-6 in mouse vascular smooth muscle cells ] . Positive_regulation TNF IL18 20056085 2193671 significantly *increased* the mRNA expression and protein secretion of [TNF-alpha] and IL-6 ( P > 0.01 ) in a dose dependent and a time dependent ways . Positive_regulation TNF IL18 20056085 2193675 NAC inhibited the mRNA expression and protein secretion of [TNF-alpha] and IL-6 *induced* by ( P > 0.01 ) . Positive_regulation TNF IL18 20056085 2193679 N-acetylcysteine antagonizes the production of [TNF-alpha] and IL-6 *induced* by in VSMC . Positive_regulation TNF IL18 20084439 2258650 promotes inflammation and *induces* IFN-gamma and [tumor necrosis factor (TNF)-alpha] as the expression of IFN-gamma and TNF-alpha cytokines was evident in this study . Positive_regulation TNF IL18 20131228 2219907 [TNFalpha] *induced* RA synovial fibroblast IL-18BPa and in a time dependent manner ( P < 0.05 ) . Positive_regulation TNF IL18 20131228 2219910 Evaluation of signaling pathways suggested that [TNFalpha] *induced* production through the ERK-1/2 , protein kinase Cdelta (PKCdelta) , and Src pathways , whereas IL-18BPa synthesis was mediated through the NFkappaB , PKC , Src , and JNK pathways . Positive_regulation TNF IL18 21113640 2407572 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL18 2113076 135519 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL18 21225442 2457847 *induces* production of [tumor necrosis factor-a] and promotes T helper (Th)1-type immune responses . Positive_regulation TNF IL18 21871585 2510357 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL18 22198666 2629422 *induces* IFN-? , IL-17 , and [TNF-a] , which may play an important pathogenic role in AOSD . Positive_regulation TNF IL18 22784440 2719528 However , PGE2 alone stimulated the secretion of 208±89 pg IL-10/ml whereas alone did not *stimulate* the secretion of IL-10 , IL-12 , [TNF-a] or INF-? . Positive_regulation TNF IL18 22870498 2641390 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL18 22995521 2689017 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL18 23702712 2792424 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL18 23938462 2895766 The cascade involved prostaglandin E2 ( PGE2 ) production from melanoma induced by *dependent* [tumor necrosis factor-a (TNFa)] ; Positive_regulation TNF IL18 2404745 128014 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL18 2471522 111729 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL18 3011946 59731 [Tumor necrosis factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL18 3260265 94474 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL18 3486936 60073 [Tumor necrosis factor] ( cachectin ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL18 3526909 62623 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL18 7536712 300179 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL18 8132326 251497 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL18 8333833 223716 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL18 8592105 341942 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL18 9378984 465720 These data suggested that *activates* both [TNF-alpha-] and FasL mediated hepatocytotoxic pathways in endotoxin induced liver injury . Positive_regulation TNF IL18 9449707 483974 IL-18 did not induce antiinflammatory cytokines , IL-1Ra , or IL-10 , although *induction* of [TNFalpha] was inhibited by IL-10 . Positive_regulation TNF IL18 9449707 483980 In the presence of IFNgamma , *induced* [TNFalpha] was enhanced and there was an increase in the mature form of IL-1beta . Positive_regulation TNF IL18 9548401 498861 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL18 9893178 586784 *induces* gene expression and synthesis of [TNF] , IL-1 , Fas ligand , and several chemokines . Positive_regulation TNF IL18 9917859 559109 Nevertheless , IL-18 may contribute to inflammation and fever because is a potent *inducer* of [tumor necrosis factor] , chemokines , and interferon-gamma production . Positive_regulation TNF IL19 12370360 995882 *induces* production of IL-6 and [TNF-alpha] and results in cell apoptosis through TNF-alpha . Positive_regulation TNF IL19 15517620 1328648 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL19 1598496 188834 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL19 21113640 2407573 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL19 2113076 135520 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL19 21719423 2554442 In vitro , *induced* [TNF-a] , IL-1ß , IL-6 and RANKL expression in CIA SFs . Positive_regulation TNF IL19 21871585 2510358 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL19 22870498 2641391 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL19 22995521 2689018 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL19 23468852 2750139 upregulated TNF-a and IL-10 in cultured HepG2 cells , and it *increased* IL-1ß and [TNF-a] expression in cultured A549 cells . Positive_regulation TNF IL19 23702712 2792425 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL19 2404745 128015 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL19 2471522 111730 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL19 3011946 59732 Tumor necrosis [factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL19 3260265 94475 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL19 3486936 60074 Tumor necrosis factor ( [cachectin] ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL19 3526909 62624 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL19 7536712 300180 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL19 8132326 251498 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL19 8333833 223717 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL19 8592105 341943 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL19 9548401 498862 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL1A 10433877 634176 These results suggest that RGAE may *inhibits* [TNF-alpha] secretion by inhibiting secretion and that RGAE has an anti-inflammatory activity in the central nervous system curing some pathological disease states . Positive_regulation TNF IL1A 10445612 636211 Inhibition of TNF-alpha- and induced p38 MAP kinase activity by SB 203580 *inhibited* [TNF-alpha-] and IL-1alpha induced IL-8 protein production as well as IL-8 messenger ribonucleic acid ( mRNA ) expression , indicating that SB 203580 was effective at the transcriptional level . Positive_regulation TNF IL1A 10454832 626321 Plasma LTB , and [TNF] were *reduced* by blockade , compared with septic controls . Positive_regulation TNF IL1A 10454832 626322 [TNF] release is stimulated in the *presence* of unopposed and may be synergistic with it in the adverse hemodynamic effects of endogenous IL-1 . Positive_regulation TNF IL1A 10469303 641088 Ultraviolet B and synergistically *increased* [tumor necrosis factor-alpha] secretion by fibroblasts , a finding not seen with ultraviolet B alone nor with ultraviolet A or ultraviolet A1 combined with interleukin-1 alpha . Positive_regulation TNF IL1A 10469303 641089 We conclude that in combination specifically with ultraviolet B *induces* fibroblasts to secrete [tumor necrosis factor-alpha] , and that this ultraviolet B-specific induction of tumor necrosis factor-alpha secretion is responsible for effects of ultraviolet B on the expression of matrix related genes in the skin . Positive_regulation TNF IL1A 10573218 568795 Therefore the effect of a beta2-agonist , procaterol and theophylline on the release of ECA from a BEC line , BEAS-2B was evaluated in *response* to and [tumour necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF IL1A 10669637 665835 *induced* expression and secretion of [TNF-alpha] protein , but LPS did not induce production of TNF-alpha protein . Positive_regulation TNF IL1A 10820229 694034 Here we report that in primary mouse bone marrow derived mast cells activated by ionomycin or IgE/Ag , the proinflammatory mediator ( alpha or beta ) *up-regulated* production of IL-3 , IL-5 , IL-6 , and IL-9 as well as [TNF] , i.e. , cytokines implicated in many inflammatory processes including those associated with allergies and helminthic infections . Positive_regulation TNF IL1A 10946829 721622 Our results suggest that TO may *inhibit* [TNF-alpha] production by inhibiting production and that TO has an antiinflammatory activity in the central nervous system . Positive_regulation TNF IL1A 11254623 794050 This increased severity of disease was associated with reduced ocular and *increased* [tumor necrosis factor] alpha mRNA production compared with WT mice . Positive_regulation TNF IL1A 11322653 807164 Our results suggest that Chilbokeum may *inhibit* [TNF-alpha] secretion by inhibiting secretion and that Chilbokeum has an antiinflammatory activity in the central nervous system . Positive_regulation TNF IL1A 11526216 853137 Furthermore , a bacterial mutant that does not induce expression but *induces* normal levels of IL-1 beta , [TNF-alpha] , and IFN-gamma , causes greatly reduced intestinal inflammation and is attenuated by LD ( 50 ) analysis in the C57BL/6 mouse model . Positive_regulation TNF IL1A 11562770 862897 *induced* the production of IL-6 , GM-CSF and [TNFalpha] from immortalized chondrocytes . Positive_regulation TNF IL1A 11743653 897867 iii ) In transformed clones of BALB/3T3 cells induced by TNF-alpha alone , gene expression was *induced* after transformation by [TNF-alpha] had occurred , which did not occur in parental cells . Positive_regulation TNF IL1A 11746781 897987 TaqMan real-time quantitative PCR analysis revealed that *stimulated* gene expression of [tumor necrosis factor-alpha (TNF)] in striatal cultures . Positive_regulation TNF IL1A 11807961 906412 Our results suggest that Sesim-Tang may *inhibit* [TNF-alpha] secretion by inhibiting secretion and that Sesim-Tang has an antiinflammatory activity in the central nervous system . Positive_regulation TNF IL1A 11856640 914384 In addition , [TNF-alpha] *induces* release by synovial fibroblasts and macrophages , and IL-1 , together with RANKL , is a major survival and activation signal for nascent osteoclasts . Positive_regulation TNF IL1A 12020969 942714 Treatment with SB203580 , a specific inhibitor of p38 mitogen activated protein kinases (MAPK) , potently inhibited *mediated* induction of iNOS and [TNFalpha] in cultures of human fetal astrocytes . Positive_regulation TNF IL1A 12022445 943278 These results suggest that YH-Tang may indirectly *inhibit* [TNF-alpha] secretion by inhibiting secretion . Positive_regulation TNF IL1A 12164270 972672 Our results suggest that SSGP may *inhibit* [TNF-alpha] secretion by inhibiting secretion and that SSGP has an antiinflammatory activity in the CNS . Positive_regulation TNF IL1A 12236623 989119 also augments osteoclast activation , and [TNF-alpha] *induces* differentiation of early osteoclast precursors . Positive_regulation TNF IL1A 12370796 1034768 increased by 140 % in osteoclasts by day 3 and [TNF alpha] *increased* in osteoclasts by 120 % and 500 % in megakaryocytes on day 12 . Positive_regulation TNF IL1A 12482390 1024373 Using sensitive ELISAs , we found that Na ( 2 ) SO ( 3 ) *induces* the total ( intra- and extracellular fractions ) production of interleukin-12 (IL-12) and IL-8 but not [TNF-alpha] , , or IL-4 . Positive_regulation TNF IL1A 12578855 1058251 On the other hand , [TNF-alpha] , *induced* by , was necessary for the induction of local inflammation during the elicitation phase . Positive_regulation TNF IL1A 12598651 1064359 In addition to the in vivo findings , *contributed* to the production of vascular endothelial cell growth factor and [tumor necrosis factor] in cocultures of peritoneal macrophages and tumor cells . Positive_regulation TNF IL1A 12676771 1076911 Chemotactic chemokines can be released from lung fibroblasts in *response* to and [tumor necrosis factor (TNF)-alpha] . Positive_regulation TNF IL1A 12709026 1083025 The expression of TLR2 protein by hepatocytes was also remarkably *up-regulated* by and , to a lesser extent , by [TNF-alpha] as well , but not by LPS or BLP . Positive_regulation TNF IL1A 1280478 203153 Human arterial smooth muscle cells synthesize granulocyte colony stimulating factor in *response* to and [tumor necrosis factor-alpha] . Positive_regulation TNF IL1A 1337985 208050 Characterization of the TNF-R by flow cytometric analysis revealed increased membrane expression of the 75 kDa , but not the 55 kDa , [TNF] binding protein as a *result* of costimulation . Positive_regulation TNF IL1A 1374105 186283 These findings suggest that autocrine/paracrine is involved in the initial generation of LAK activity and , in particular , that [TNF] expression could be *induced* via an IL-1 autocrine pathway . Positive_regulation TNF IL1A 1405754 199645 *induced* the endogenous secretion of GM-CSF , IL-6 , and [TNF] in most cases . Positive_regulation TNF IL1A 1533322 186447 *induces* IL-1 , [tumor necrosis factor alpha (TNF alpha)] , and IL-6 gene expression and synthesis in a variety of cells . Positive_regulation TNF IL1A 1533322 186455 Suppression of *induced* IL-1 , [TNF alpha] , or IL-6 synthesis was dose dependent ( P less than or equal to .0001 ) . Positive_regulation TNF IL1A 1533322 186459 At a twofold molar excess , IL-1ra inhibited *induced* IL-1 or [TNF alpha] synthesis by 50 % ( P less than .01 ) ; Positive_regulation TNF IL1A 1533323 186468 can also *induce* PBMC to synthesize IL-1 and [TNF alpha] . Positive_regulation TNF IL1A 1536986 180511 The results showed that 17 beta-oestradiol ( 10 ( -10 ) and 10 ( -8 ) M ) inhibited *stimulated* [TNF] release in a dose dependent manner in 7 out of 9 patients . Positive_regulation TNF IL1A 15668736 1369640 Reflecting sequential signaling of the cytokines TNF and IL-1 , [TNF] *induces* stromal cell expression of and IL-1RI . Positive_regulation TNF IL1A 15672633 1350771 and IL-1beta mRNA expression increased significantly ( p < 0.05 vs. sham-injury ) after severe TBI and IL-6 and [TNFa] mRNA expression *increased* significant ( p < 0.05 vs. sham-injury ) after both moderate and severe TBI . Positive_regulation TNF IL1A 1586593 187729 Analysis of peritoneal fluid and tumour xenografts showed that [TNF] *induced* murine in the tumour bearing mice . Positive_regulation TNF IL1A 15946654 1421016 Furthermore , we showed that t-RA could reduce *induced* [TNF-alpha] production in chondrocytes . Positive_regulation TNF IL1A 16000387 1447303 In the present study , incubation of AM with unopsonized Pneumocystis organisms was not associated with release of , IL-6 , or tumor necrosis factor (TNF)-alpha ( important cytokines in the host response to Pneumocystis ) and did not *induce* IL-1beta , IL-6 , or [TNF-alpha] mRNA transcripts . Positive_regulation TNF IL1A 16087381 1517216 Experimental data suggest that may be *involved* chiefly in joint destruction and [TNF] in joint inflammation . Positive_regulation TNF IL1A 1639487 194647 *Induction* of [tumor necrosis factor (TNF)] and interleukin-1 (IL-1) by Pseudomonas aeruginosa and exotoxin A-induced suppression of lymphoproliferation and TNF , lymphotoxin , gamma interferon , and production in human leukocytes . Positive_regulation TNF IL1A 16565381 1538929 JNK activity is necessary for the *induction* of MMP-9 and [TNFalpha] by , IL-1beta , or Jun in TM cells . Positive_regulation TNF IL1A 16888805 1672716 In hepatocytes or human hepatoma cells [TNFalpha] is expressed at extremely low levels but TNFalpha biosynthesis can be *induced* by or 12-O-tetradecanoylphorbol-13-acetate ( TPA ) . Positive_regulation TNF IL1A 1695108 137069 In acute myeloid leukemia ( AML ) , *induces* autocrine granulocyte/macrophage colony stimulating factor ( GM-CSF ) and [tumor necrosis factor (TNF)] production , and these factors may then synergistically induce proliferation in AML blast cells . Positive_regulation TNF IL1A 1695108 137071 We propose a scheme where stimulation of normal bone marrow blast cells *leads* to the induction of [TNF alpha] and GM-CSF , which in association stimulate DNA synthesis efficiently according to a paracrine or autocrine mechanism within the marrow blast cell compartment . Positive_regulation TNF IL1A 1696166 137193 Both [TNF] and LT mRNA were minimally *induced* by , IL-3 , interferon (IFN)-alpha , or IFN-gamma . Positive_regulation TNF IL1A 17214584 1664074 PGE2 is also produced in response to proinflammatory cytokines , which in turn negatively regulates both IL-17 and [TNF-alpha] expression and induced *activation* of fibroblast-like synoviocytes through EP2/EP4 receptors , resulting in the modulation of proinflammatory cascades . Positive_regulation TNF IL1A 17509446 1745171 When PBMC were cultured with a2NTD , there was a 2.5-fold increase in and IL1B gene expression and no *induction* of [TNF] gene expression . Positive_regulation TNF IL1A 1774433 175457 These results suggest that [TNF] plays a major role in the pathogenesis of galactosamine/LPS hepatitis in mice and that *acts* synergistically with TNF in this hepatitis model . Positive_regulation TNF IL1A 1779975 175869 Secretion of [TNF] by these cells is *induced* by exogenous TNF , but not by . Positive_regulation TNF IL1A 1796655 176325 It will focus on , IL-1 inhibitors , [Tumor-Necrosis-Factor-alpha (TNF-alpha)] , TNF *inhibitors* , Interleukin-6 (IL-6) , colony stimulating factors (CSF's) , Interferon-gamma (IFN-gamma) , growth factors , eicosanoids and prostaglandins , all of which are important in the effector phase of tissue destruction . Positive_regulation TNF IL1A 17967442 1826504 Peripheral [TNFalpha] , but not peripheral IL-1 , *requires* endogenous or TNFalpha induction in the brain for the febrile response . Positive_regulation TNF IL1A 17968946 1826657 IL-1Ra domain activity was evaluated by surface plasmon resonance , and in vitro antagonism of IL-1 mediated lymphocyte and thymocyte proliferation , as well as *induced* [tumor necrosis factor alpha (TNFalpha)] expression and matrix metalloproteinase 3 (MMP-3) and ADAMTS-4 messenger RNA expression in human intervertebral disc fibrochondrocytes . Positive_regulation TNF IL1A 1801706 176951 Therefore , it is unlikely that [TNF] *acts* through the induction of secretion . Positive_regulation TNF IL1A 18250170 1890708 [TNF] *induces* expression and activates c-Fos , a transcription factor required in OCPs for osteoclast formation . Positive_regulation TNF IL1A 1827485 155433 CD3-4-8-IL-2R+ thymocytes only produced small amounts of IL-2 when activated with calcium ionophore + PMA + IL-1 , whereas CD3-4-8-IL-2R- thymocytes did not *require* to produce IL-2 , IFN-gamma , and [TNF-alpha] . Positive_regulation TNF IL1A 18387309 1907160 Cytocidal effect of on HeLa cells is *mediated* by both soluble and transmembrane [tumor necrosis factor (TNF)] . Positive_regulation TNF IL1A 1847164 153432 Antibody neutralization studies indicated that *induces* release of both [TNF] and LT ; Positive_regulation TNF IL1A 1894366 167240 After a second inhalation exposure , cell associated and extracellular [TNF-alpha] activity could not be *detected* , whereas activity was markedly enhanced . Positive_regulation TNF IL1A 1906383 161714 GM-CSF , IL-2 and [TNF-alpha] directly *induced* the production of cell associated IL-1 but little or no or TNF-alpha secretion . Positive_regulation TNF IL1A 1906430 161728 Likewise , secretion of by AM or TIM was also *induced* with LPS , although less than that obtained with PM. AM stimulated with LPS secreted larger amounts of [TNF] than PM while TIM secreted very low amounts of TNF . Positive_regulation TNF IL1A 1916153 168241 These results strongly suggest that has a inhibitory effect on hepatocytes in terms of DNA synthesis and that [TNF] indirectly *induces* hepatocellular damage through the serine proteases which are possibly activated by the cytokine in vivo . Positive_regulation TNF IL1A 19196726 2182384 To determine whether [TNF] directly triggers bone loss or *requires* , human TNFalpha mice ( hTNFtg ) were crossed with mice lacking IL1alpha and IL1beta ( IL1 ( -/- ) hTNFtg ) . Positive_regulation TNF IL1A 1920018 168475 As determined by ELISA of tissue extracts , IL-1 beta and [TNF alpha] were *detected* in all diseased sites , whereas was present in 8/22 sites , IL-1 beta was present in highest concentration ( mean +/- SEM : 11,695 +/- 2,888 pg/ml ; 672 pM ) , followed by TNF alpha ( 434 +/- 135 pg/ml ; 26 pM ) , and IL-1 alpha ( 342 +/- 160 pg/ml ; 20 pM ) . Positive_regulation TNF IL1A 1942768 170695 We report that transformed TEC express low levels of [TNF alpha] in *response* to LPS or as a secreted product and as a cytotoxic membrane associated molecule displayed on the cell surface . Positive_regulation TNF IL1A 19569215 2208817 We added both lipopolysaccharide (LPS)-free and endotoxin associated xUHMWPE and PCU particles to a human monocyte cell line ( TH1 ) in culture and measured cell viability and tumor necrosis factor (TNF)alpha , , and prostaglandin E ( 2 ) ( PGE ( 2 ) ) in the medium after 24 h. Results indicate that particles ( both xUHMWPE and PCU ) free of endotoxin did not significantly *induce* secretion of [TNFalpha] , IL-1beta , or PGE ( 2 ) above basal levels . Positive_regulation TNF IL1A 19648252 2125413 ( 0.001-10 ng/ml , 0-6 h ) *stimulated* IL-1beta , [TNF-alpha] , and IL-6 mRNA expression with distinct temporal and concentration profiles , resulting in increased cytokine secretion . Positive_regulation TNF IL1A 20220144 2249413 We demonstrated previously that the gene encoding NGAL ( LCN2 ) is strongly *up-regulated* by in an NF-kappaB dependent manner but not by [tumor necrosis factor (TNF)-alpha] , another potent activator of NF-kappaB . Positive_regulation TNF IL1A 20493505 2367813 Lipopolysaccharide was a more potent inducer of and CXCL-8 than LTA or PG and LTA is a more potent inducer of CXCL-8 than PG. Based on these data , PAMPs from gram positive and negative bacteria *induce* [TNF] , IL-1ß and CXCL-8 production in feline whole blood . Positive_regulation TNF IL1A 20610641 2296853 Furthermore , we showed that directly *enhanced* [TNF] and chemokine expression in keratinocytes . Positive_regulation TNF IL1A 20655404 2322159 However , geniposide did not decrease [TNF-a] release *induced* by CpG DNA , Poly I:C or . Positive_regulation TNF IL1A 2109008 131126 Astrocyte TNF-alpha production by IFN-gamma/LPS stimulation can be inhibited by the addition of anti-rat IFN-gamma antibody , whereas *induced* [TNF-alpha] production is inhibited by antibody to either IFN-gamma or IL-1 beta . Positive_regulation TNF IL1A 2113076 135557 *stimulated* both IL-1 beta and [TNF-alpha] , but there was no correlation in the amount of TNF-alpha or IL-1 beta synthesized in the PBMC of 29 individuals . Positive_regulation TNF IL1A 2113076 135559 Coincubation with interferon-gamma (IFN-gamma) did not change the amount of *induced* [TNF-alpha] , whereas in the same culture IFN-gamma inhibited ( greater than 70 % ) Positive_regulation TNF IL1A 2113076 135560 These studies demonstrate that *induced* [TNF-alpha] production in vivo and in vitro . Positive_regulation TNF IL1A 2115419 137420 [TNF-alpha] induced a significant amount of IL-1 ( mainly cell associated ) directly but could also *induce* secretion when combined with IL-2 or IFN-gamma , or when in the presence of serum . Positive_regulation TNF IL1A 21273803 2360661 [TNF-a] , and IL-6 expression *increased* early in the lungs and pancreas , with a partial recovery by the end of the study . Positive_regulation TNF IL1A 21417548 2463532 IL-1ß and [TNF] strongly *increased* PGE2 production , with as the most prominent inducer . Positive_regulation TNF IL1A 21477368 2417537 Secretion of IL-6 , IL-8 , and [TNF-a] , but not TGF-ß1 , was *increased* by stimulation . Positive_regulation TNF IL1A 21515850 2434953 Coculture of WT , but not ( -/- ) macrophages , with 3T3L1 adipocytes *enhanced* IL-6 and [TNF-a] secretion , reduced adiponectin secretion , and impaired adipocyte insulin sensitivity . Positive_regulation TNF IL1A 21833523 2658045 In response to mild hypothermia , an enhanced expression by patient monocytes *resulted* in increased IL-6 and [TNF-a] secretion , as compared to control cells . Positive_regulation TNF IL1A 21899910 2511009 SDEE inhibits *stimulated* NO , [TNF-a] release , and iNOS expression . Positive_regulation TNF IL1A 21961050 2488262 Effect of novel marine nutraceuticals on *mediated* [TNF-a] release from UVB irradiated human melanocyte derived cells . Positive_regulation TNF IL1A 2201834 140496 Hemopoietin-1 activity of interleukin-1 (IL-1) on acute myeloid leukemia colony forming cells ( AML-CFU ) in vitro : *induces* production of [tumor necrosis factor-alpha] which synergizes with IL-3 or granulocyte-macrophage colony stimulating factor . Positive_regulation TNF IL1A 22056354 2527958 Gene expression ( mRNA ) of MCP-1 , IL-1ß , IL-6 and [TNF-a] was *increased* in sections 2 and 3 starting at week 12 ( P < 0.05 ) , with further increases in MCP-1 , and IL-6 at 16 weeks ( P < 0.05 ) . Positive_regulation TNF IL1A 22608768 2681537 [Tumor necrosis factor] , NONOate , and TNF + + NONOate *increased* LTB ( 4 ) production ( P < 0.01 ) , whereas LTC ( 4 ) was increased by LPS , TNF , and IL-1a ( P < 0.01 ) . Positive_regulation TNF IL1A 22714807 2659488 In the PS group , [TNF-a] increased at 1 , 3 , and 5 weeks and *increased* significantly after 1 and 3 weeks of stress , and then decreased to normal levels by 5 weeks . Positive_regulation TNF IL1A 22730040 2639073 PANSS scores and plasma levels significantly decreased , but plasma [TNF-a] and BDNF levels significantly *increased* after 11 weeks of Risp treatment . Positive_regulation TNF IL1A 23046548 2706510 Unopsonized IE *induced* secretion of IL-6 ( median= 622 pg/ml [ IQR=1,250-240 ] , n=9 ) but no IL-1ß or [TNF] , whereas PPS opsonized IE induced secretion of ( 18.6 pg/mL [ 34.2-14.4 ] ) and TNF ( 113 pg/ml [ 421-17.0 ] ) and increased IL-6 secretion ( 2,195 pg/ml [ 4,658-1,095 ] ) . Positive_regulation TNF IL1A 23071098 2720891 Mixed-effects modeling analysis of our data was vital for ascertaining that and TGF-a treatment increased the activities of more pathways than IL-6 and TNF-a and that TGF-a and [TNF-a] *increased* p38 MAPK and c-Jun N-terminal kinase (JNK) phospho-protein levels in a synergistic manner . Positive_regulation TNF IL1A 23208413 2705385 Gene expression analyses showed that TNF-a and *stimulate* the adipocyte expression of [TNF-a] , IL-1ß and IL-6 . Positive_regulation TNF IL1A 23487424 2766595 directly *augments* [TNF] signaling in macrophages through the upregulation of TNF secretion and TNFR1 cell surface expression , and results in activation of caspase-3 . Positive_regulation TNF IL1A 23595503 2800062 LPS or LAM induced TNF-a production was 5 to 18 times higher in AB than in CB monocytes , whereas *stimulated* similar levels of [TNF-a] in both groups , suggesting that decreased responses to LPS or LAM in CB are unlikely to be due to differences in the MyD88 dependent signaling pathway . Positive_regulation TNF IL1A 23685224 2805891 LPS and significantly *increased* the expression of pro-inflammatory cytokines ( [TNF-a] , IL-8 and IL-6 ; and IL-1ß and IL-8 respectively ) . Positive_regulation TNF IL1A 23840908 2816430 Systemic could not *induce* significant blood [TNF-a] , but induced CNS TNF-a mRNA , while systemic TNF-a could induce IL-1ß in blood and brain . Positive_regulation TNF IL1A 2407890 130405 However , stimulation with or LPS *induces* [TNF-alpha] transcripts . Positive_regulation TNF IL1A 2460533 98577 Using Northern blot analysis to detect tissue levels of hematopoietic growth factor-specific transcripts , and specific biologic and immunologic assays to detect the presence of colony stimulating factors in the serum , we have found that [TNF-alpha] and TNF-beta *induce* the transcription and production of granulocyte-macrophage-CSF , macrophage-CSF , and . Positive_regulation TNF IL1A 2469651 109547 was also without effect , but [TNF] *increased* the proportion of HLA-DR+ cells in both CB and adult peripheral blood ( PBL ) -derived T lymphoblasts . Positive_regulation TNF IL1A 24928389 2946777 however , does not *induce* [TNF] secretion . Positive_regulation TNF IL1A 24928389 2946780 With metabolic labeling based proteomics and pathway analysis , we found that significantly *increases* the [TNF] downstream protein expression in FLS even with complete absence of TNF and/or blocking of the NF-?B pathway . Positive_regulation TNF IL1A 2496917 109699 The purpose of this study was to determine if recombinant murine interleukin 1 beta ( rMu-IL-1 beta ) alone or in combination with recombinant murine gamma-interferon ( rMu-IFN-gamma ) could activate murine macrophages to be tumoricidal against tumor necrosis factor (TNF)-insensitive target cells and to evaluate the possible *role* of in murine macrophage activation by recombinant murine tumor necrosis factor ( [rMu-TNF] ) plus rMu-IFN-gamma . Positive_regulation TNF IL1A 2496917 109703 There was no evidence , however , that the production of was *required* for macrophage activation by [rMu-TNF] in combination with rMu-IFN-gamma . Positive_regulation TNF IL1A 2523925 109920 Although IL-4 or [TNF] did not *induce* significant B cell expression , they both caused a modest , but reproducible enhancement when added in combination with IL-2 . Positive_regulation TNF IL1A 2523936 109932 Because [TNF] *induces* membrane in fibroblasts , it is possible to speculate that the effects of TNF on fibroblasts are due to induction of IL-1 . Positive_regulation TNF IL1A 2610269 123816 [Tumor necrosis factor] and *increase* vascular endothelial permeability . Positive_regulation TNF IL1A 2961377 84135 Recombinant had no effect on receptor expression , but recombinant [TNF] *increased* CR1 and CR3 expression with kinetics similar to the supernatants . Positive_regulation TNF IL1A 3038998 76271 and PMA together *had* an additive effect on [TNF] binding . Positive_regulation TNF IL1A 3045826 97119 We also demonstrated that the [IL-2/TNF] synergistic induction of LAK activity did not *involve* either or interferon-gamma . Positive_regulation TNF IL1A 3140909 99666 Therefore , it is unlikely that [TNF] *acts* through the induction of secretion by endothelial cells . Positive_regulation TNF IL1A 3258346 91895 In comparison , [TNF alpha] even at 100,000 U , *induced* only mild PMNL accumulations , although and TNF alpha were similarly active in inducing PMNL adherence to human umbilical vein endothelium . Positive_regulation TNF IL1A 3262629 97886 The and [TNF] *induction* of EC adhesivity was both concentration ( threshold concentration 1 U/ml ) and time dependent ( peak 4-6 h ) , reversible within 24 h , and blocked by a protein synthesis inhibitor . Positive_regulation TNF IL1A 3264252 101495 The results suggest that early changes in serine/threonine protein kinase activity may be involved in *responses* of fibroblasts to and [TNF] . Positive_regulation TNF IL1A 3494060 72246 Induction with TNF resulted in the appearance of IL 1-alpha mRNA and a very significant increase in IL 1-beta mRNA , indicating that [TNF] *induces* the synthesis of both and IL 1-beta in FS-4 cells . Positive_regulation TNF IL1A 7473001 331451 The results indicate that [TNF alpha] *induces* production of cell associated in gingival fibroblasts , which can be upregulated by a PKC dependent pathway . Positive_regulation TNF IL1A 7506735 244450 We investigated whether *mediates* the SP enhancement of [TNF-alpha] secretion . Positive_regulation TNF IL1A 7534264 296901 Immunocytochemistry of frozen sections from sponges showed that E-selectin expression was *up-regulated* markedly by [TNF-alpha] and PHA at 5 hr , only moderately by at 5 hr , and not at all by PMA at 5 hr . Positive_regulation TNF IL1A 7579439 329704 *upregulates* [tumor necrosis factor] receptors expressed by a human bone marrow stromal cell strain : implications for cytokine redundancy and synergy . Positive_regulation TNF IL1A 7579439 329705 *induction* of [TNF] receptors reaches a peak after 6 hours and gradually returns to baseline level by 24 hours . Positive_regulation TNF IL1A 7579439 329706 A kinetic study comparing IL-1/TNF synergistic induction of growth factor secretion with *induction* of [TNF] receptors shows that these events occur in parallel . Positive_regulation TNF IL1A 7579439 329707 In contrast with the *induction* of [TNF] receptors by , treatment with TNF alpha has no effect on either the number of IL-1 receptors expressed by CDCL cells or IL-1 receptor ligand binding affinity . Positive_regulation TNF IL1A 7583580 333552 We show that physiological concentrations of HDLs inhibit [tumor necrosis factor-alpha (TNF-alpha)] or *induction* of these leukocyte adhesion molecules in a concentration dependent manner . Positive_regulation TNF IL1A 7670776 322591 In addition , clinical improvement was associated with decreased synthesis of IL-1 beta , [TNF-alpha] and IL-8 *induced* by bacterial lipopolysaccharide , and IL-1 beta in PBMC in vitro . Positive_regulation TNF IL1A 7738426 305692 [TNF] activity in BAL fluid was markedly *increased* by LPS , TNF , and + TNF , with a smaller increase induced by IL-1 . Positive_regulation TNF IL1A 7873200 296652 Likewise , coinsufflation of IL-1 and anti-TNF antibody , which completely neutralized *induced* [TNF] activity , had no effect on IL-1 induced alveolar inflammatory response and O2 tolerance . Positive_regulation TNF IL1A 7879702 287697 Human recombinant [tumour necrosis factor-alpha (TNF-alpha)] and the calcium ionophores A23187 and ionomycin *induced* a concentration dependent increase of cell associated but failed to cause release of IL-1 at concentrations producing maximal stimulation of cell associated IL-1 . Positive_regulation TNF IL1A 7957562 278065 Further , *stimulated* production of [TNF-alpha] was diminished by IL-10 and only a small proportion of this TNF-alpha was bioactive , consistent with increased production of inhibitory soluble TNF-R . Positive_regulation TNF IL1A 7959299 278684 TNF and inhibitors originate from tumor cells and tumor associated macrophages and probably *block* [TNF] and IL-1 activity locally and regionally in ovarian carcinoma patients . Positive_regulation TNF IL1A 7962270 279361 Expression of E-selectin on endothelial cells was *induced* only by , not by IFN gamma or [TNF alpha] . Positive_regulation TNF IL1A 8048540 267135 Furthermore , IL-1ra downregulated both LPS and *induced* [TNF-alpha] release to 84 +/- 4 % ( P = 0.012 by paired t test ) and 49 +/- 9 % ( P = 0.001 by paired t test ) of control , respectively . Positive_regulation TNF IL1A 8068940 269928 CA also decreased *induced* increase in plasma [tumor necrosis factor] levels at the time point examined . Positive_regulation TNF IL1A 8168971 255033 Since *induces* production of [tumor necrosis factor alpha (TNF-alpha)] , granulocyte-macrophage colony stimulating factor ( GM-CSF ) , platelet activating factor (PAF) , and arachidonic acid metabolites , we investigated the potential role of these substances in IL-1 induced protection . Positive_regulation TNF IL1A 8175024 255498 Recombinant and tumor necrosis factor-alpha (TNF-alpha) can *induce* endogenous [TNF-alpha] mRNA expression and stimulate proliferation of epithelial ovarian cancer cells . Positive_regulation TNF IL1A 8175024 255500 Antisense transfected cells showed a 4.5- to 26-fold reduction in *induced* [TNF-alpha] secretion . Positive_regulation TNF IL1A 8179914 256085 Given that mononuclear phagocytes can produce both the proinflammatory cytokines , IL-1 beta , and TNF-alpha as well as the suppressive cytokine IL-1ra , we proposed that IL-1 alpha , IL-1 beta , and [TNF-alpha] may *induce* IL-1ra from mononuclear phagocytes . Positive_regulation TNF IL1A 8216333 231635 3-Morpholino-sydnonimine ( SIN-1 ) enhanced *induced* [TNF] synthesis to a maximum of 272 % ( mean of n = 5 donors ) , with 100 % set as TNF production by stimulation with IL-1 alpha alone . Positive_regulation TNF IL1A 8288913 247625 Thus , interleukin-1 alpha may be an important regulator of Langerhans cell antigen presenting function , having effects that are partially mediated via *induced* up-regulation of [tumor necrosis factor-alpha] secretion within the skin . Positive_regulation TNF IL1A 8331299 223597 [Tumor necrosis factor-alpha] *induces* and interleukin-1 receptor antagonist production by cultured human keratinocytes . Positive_regulation TNF IL1A 8333833 223728 The supplementation of cycloheximide ( CHX ) together with IL-1 beta resulted in the superinduction of TNF-alpha mRNA , suggesting that de novo protein synthesis is not required in *induced* [TNF-alpha] mRNA expression . Positive_regulation TNF IL1A 8429684 212726 Purified T-cells did not produce significant levels of [TNF-alpha] , even in the *presence* of and IL-6 . Positive_regulation TNF IL1A 8454591 215287 Deletion analysis of the 5'-flanking region of the TSG6 DNA linked to the chloramphenicol acetyltransferase reporter gene revealed that a construct containing TSG6 DNA from positions -165 to +78 could be transcriptionally *activated* by , and to a lesser extent by [TNF] , upon transfection into FS-4 fibroblasts . Positive_regulation TNF IL1A 8592105 341982 Furthermore , TNF-alpha induced LIF mRNA is blocked by the IL-1 receptor antagonist , whereas IL-1 induced LIF mRNA is not affected by TNF-alpha antibodies , suggesting that [TNF-alpha] first induces IL-1 , and subsequently *induces* LIF . Positive_regulation TNF IL1A 8671447 375123 ( 1.4-140 pmol/l ) *caused* a dose dependent increase in [TNF-alpha] production by cells prepared from both proliferative and secretory endometrium . Positive_regulation TNF IL1A 8698389 365856 Three weeks after ending aspirin medication , ex vivo IL-1 beta and [TNF] synthesis *induced* by exogenous was elevated threefold compared to the pre-aspirin value ( P = 0.01 and P = 0.005 , respectively ) . Positive_regulation TNF IL1A 8875566 390057 [TNF-alpha] *induced* a significant decrease in the total number of tachyzoites , whereas surprisingly induced an increase in the number of tachyzoites . Positive_regulation TNF IL1A 8890921 391917 The purpose of this study was to examine regulation of *induced* [tumor necrosis factor-alpha (TNF-alpha)] production by a mouse beta-cell line ( beta TC1 ) . Positive_regulation TNF IL1A 8890921 391918 Addition of exogenous TNF-alpha did not inhibit *induced* transcription of [TNF-alpha] gene . Positive_regulation TNF IL1A 9033245 415117 [TNF] activity was *detected* in samples from nine women , whereas was not found in any sample . Positive_regulation TNF IL1A 9089293 421815 We show for the first time that , a regulator of trophoblast development , *induces* [TNF-alpha] expression in proliferating cytotrophoblastic cells and purified term trophoblasts . Positive_regulation TNF IL1A 9089293 421818 Besides demonstration of this novel mechanism of *stimulated* [TNF-alpha] expression , our data indicate an important role of IL-1 in TNF-alpha production of cytotrophoblastic cells . Positive_regulation TNF IL1A 9168062 432612 In contrast , *induced* monocyte secretion of [tumor necrosis factor (TNF)] was inhibited by HCS . Positive_regulation TNF IL1A 9207825 440880 induced trophoblastic apoptosis and *increased* the serum level of [tumor necrosis factor-alpha] . Positive_regulation TNF IL1A 9208877 441009 Interferon-alpha2b is a potent inhibitor in vitro of the *induction* of IL-1 and [tumor necrosis factor] by and can induce high circulating levels of the anti-inflammatory soluble tumor necrosis factor receptor and IL-1 receptor antagonist in humans . Positive_regulation TNF IL1A 9337519 458237 *stimulates* necrotizing activity of [TNF-alpha] and augments cachexia by anabolism of lipid induction . Positive_regulation TNF IL1A 9357863 462083 We investigated expression of 92-kDa gelatinase and TIMP-1 in *response* to lipopolysaccharide (LPS) and to the proinflammatory cytokines and [tumor necrosis factor (TNF)-alpha] . Positive_regulation TNF IL1A 9430492 482109 Although did not support GM-CSF induced eosinophil transendothelial migration , IL-1 and [TNF-alpha] *induced* equivalent expression of ICAM-1 on HUVEC . Positive_regulation TNF IL1A 9439980 475063 Curcumin inhibits and [TNF-alpha] *induction* of AP-1 and NF-kB DNA binding activity in bone marrow stromal cells . Positive_regulation TNF IL1A 9448041 483772 The [TNF-alpha] level in the supernatants significantly increased at 120 min after allergen stimulation , and the level *increased* in 4 of 15 samples . Positive_regulation TNF IL1A 9558730 500199 that [TNF] *induced* and IL6 production relate in a positive curvilinear fashion to linoleic acid intake ; Positive_regulation TNF IL1A 9575340 502652 Central differentially *regulates* peripheral IL-6 and [TNF] synthesis . Positive_regulation TNF IL1A 9575340 502656 The results suggest that brain *induces* peripheral production of IL-6 , but not of [TNF] , through autonomic nervous system activation . Positive_regulation TNF IL1A 9705011 525647 These results suggest that PTAE may *inhibit* [TNF-alpha] secretion by inhibiting secretion and that PTAE has an anti-inflammatory activity on the central nervous system curing some pathological disease states . Positive_regulation TNF IL1A 9730251 530250 These results suggest that ACAE may *inhibit* [TNF-alpha] secretion by inhibiting secretion and that ACAE has a antiinflammatory activity in the central nervous system . Positive_regulation TNF IL1A 9764841 537432 Previous experiments indicated that the suppressive effects of on induction of immunity may be *mediated* by [TNF alpha] . Positive_regulation TNF IL1A 9764841 537433 Therefore , the ability of or IL-1beta to *induce* epidermal cell production of [TNF alpha] was assessed . Positive_regulation TNF IL1B 10482306 643820 [Tumor necrosis factor-alpha] and *increase* the Fas mediated apoptosis of human osteoblasts . Positive_regulation TNF IL1B 10532635 562347 To investigate the *role* of in regulation of [tumor necrosis factor-alpha (TNF-alpha)] and intercellular adhesion molecule-1 ( ICAM-1 ) during focal cerebral ischemia , the authors studied mutant mice deficient in the IL-1 converting enzyme (ICE) gene ( ICE knockout [ KO ] mice ) . Positive_regulation TNF IL1B 10533055 562399 Our results demonstrate a potent neurotoxicity *mediated* by the cytokine combination in primary human neuron-astrocyte cultures and a crucial role for endogenous [TNFalpha] in mediating neurotoxicity in this system . Positive_regulation TNF IL1B 10548204 564845 Unstimulated HUVECs did not produce detectable amounts of TNF-alpha , but IFN-gamma , , and LPS when added together *induced* [TNF-alpha] production of HUVECs in a time dependent manner . Positive_regulation TNF IL1B 10548204 564849 IFN-gamma , , or LPS alone did not *induce* [TNF-alpha] production , whereas IFN-gamma and IL-1beta in combination were able to induce TNF-alpha production to some extent , and the production could be further increased with LPS . Positive_regulation TNF IL1B 10584410 570974 The spontaneous or IFN-gamma [+TNF-alpha] <+IL-1 beta> *induced* IL-8 release was significantly augmented after the addition of neutrophils . Positive_regulation TNF IL1B 10601648 574636 Adrenomedullin suppresses *induced* [tumor necrosis factor-alpha] production in Swiss 3T3 cells . Positive_regulation TNF IL1B 10601648 574638 We demonstrated that adrenomedullin (AM) inhibited *induced* [tumor necrosis factor-alpha (TNF-alpha)] secretion and gene transcription in Swiss 3T3 fibroblasts maximally to 23 % and 18 % of control , while the other peptides elevating intracellular cAMP levels elicited much weaker effects . Positive_regulation TNF IL1B 10884313 709532 Pretreatment of astrocytes with P2 receptor antagonists , including suramin and periodate oxidized ATP ( oATP ) , resulted in a significant downregulation of *stimulated* expression of nitric oxide , tumor necrosis factor ( [TNFalpha] ) , and IL-6 at both the protein and mRNA levels , without affecting cell viability . Positive_regulation TNF IL1B 10890565 710563 The release of IL-6 and [TNF] from the ZG , ZF , ZR , and medulla was *increased* by PDB , IL-1alpha , , and LPS . Positive_regulation TNF IL1B 10900176 712701 DPI also inhibited [TNF] and LPS induced VCAM-1 and ICAM-1 cell surface expression and TNF- alpha , LPS , or *induced* VCAM-1 and ICAM-1 mRNA accumulation . Positive_regulation TNF IL1B 11031204 740163 In cells overexpressing IkappaBDeltaN , [TNF-alpha] dramatically *induced* apoptosis , whereas had no effect . Positive_regulation TNF IL1B 11115778 757915 In reaggregate cultures of rat anterior pituitaries stimulated D1 and D2 dose-dependently and D2 activity was *increased* by [TNF alpha] . Positive_regulation TNF IL1B 11404392 825490 Unexpectedly , these TLR agonists *induced* [tumor necrosis factor] alpha secretion , whereas only LPS was capable of inducing and nitric oxide secretion . Positive_regulation TNF IL1B 11592383 869691 IL-17 ( 10 ng/ml ) stimulated the expression of IL-6 mRNA by 1.3-fold , while [TNFalpha] ( 1 ng/ml ) increased it by 3.7-fold , and ( 0.1 ng/ml ) *increased* it by > 30-fold . Positive_regulation TNF IL1B 11698503 878198 However , neither TNF-alpha nor induced IRAK degradation or *stimulated* [TNF-alpha] or TxB2 production in naive cells . Positive_regulation TNF IL1B 11742863 887433 We report here that SMCs isolated from the neointima of injured rat aortas are characterized by increased expression of [TNF-alpha] in *response* to and gamma-interferon compared with medial SMCs . Positive_regulation TNF IL1B 11872267 918545 The production of [TNF-alpha] and IL-6 was *induced* by and Abeta [ 25-35 ] and synergistically amplified by the co-stimulation of IL-1beta and Abeta [ 25-35 ] . Positive_regulation TNF IL1B 11943316 928688 The objectives of this study were to determine , IL-2 , IL-4 , IL-5 , IL-6 , IL-8 , IL-10 , interferon (IFN)-gamma and [tumor necrosis factor (TNF)-alpha] *induction* in bronchoalveolar lavage (BAL) of control horses and horses with heaves both during remission and exacerbation of the disease , and to determine the effect of therapy with inhaled fluticasone propionate on the cytokine profile of horses with heaves . Positive_regulation TNF IL1B 12069185 955442 Iron supplementation of macrophage cultures significantly increased *induced* [TNF] release . Positive_regulation TNF IL1B 12127790 966177 We evaluated the constitutive and *induced* expression of GM-CSF and [TNF-alpha] and the expression/activity of NF-kappaB in HPV+ and HPV- cell lines . Positive_regulation TNF IL1B 12135770 967599 Here we demonstrated that E. coli carrying the cloned enterohemolysin operon ( hlyC , A , B , D genes ) from an STEC human strain *induced* the production of through its mRNA expression but not [tumor necrosis factor-alpha] from human monocytes . Positive_regulation TNF IL1B 12379764 997313 GROalpha does not seem to initiate [TNFalpha] , IL-1beta , and IL-8 in an early phase , but *induces* and IL-8 in a late phase . Positive_regulation TNF IL1B 12468033 1022523 We found that *induces* de novo synthesis of additional IL-1beta but not [TNFalpha] , as determined by RT-PCR and ELISA , and TNFalpha does not induce either itself or IL-1beta . Positive_regulation TNF IL1B 12626343 1112590 To test this hypothesis , recombinant human IL-10 was evaluated for its capacity to attenuate the release of neutrophil chemotactic activity and IL-8 from a human epithelial cell line in *response* to and [tumor necrosis factor-alpha] . Positive_regulation TNF IL1B 12676771 1076913 Similarly , the release of the chemoattractants IL-8 , granulocyte colony stimulating factor , monocyte chemoattractant protein-1 , macrophage colony stimulating factor , and granulocyte/macrophage colony stimulating factor , from HFL-1 , were evaluated in *response* to and [TNF-alpha] . Positive_regulation TNF IL1B 12695157 1080986 LEF ( 0.3 , 3 , and 9 micro g/ml ) inhibited IL1beta production in the presence of lipopolysaccharide ( LPS ; 3 micro g/ml ) in a dose dependent manner ( p < 0.01 ) at LEF 0.3 micro g/ml . [TNFalpha] production in the *presence* of ( 1 ng/ml ) was also inhibited in a dose dependent manner ( p < 0.05 at LEF 0.3 micro g/ml ) . Positive_regulation TNF IL1B 12699428 1081585 *induced* Langerhans ' cell migration and [TNF-alpha] production in human skin : regulation by lactoferrin . Positive_regulation TNF IL1B 12807444 1102033 Concomitantly , [TNF-alpha] *induced* mRNA expression by astrocytes in co-culture and this effect was partially prevented by ET-1 antibody neutralization . Positive_regulation TNF IL1B 12892443 1117786 The results showed that lipopolysaccharide and tumor necrosis factor alpha , or [TNF-alpha] , *induced* COX-2 in macrophages , while and TNF-alpha induced COX-2 in oral epithelial cells . Positive_regulation TNF IL1B 13678668 1140183 [TNFalpha] alone caused robust NO ( 2 ) ( - ) flux , while IL6 had a lesser effect and neither IFNgamma nor was *active* when applied singly . Positive_regulation TNF IL1B 1421015 202095 Recombinant *induced* a very low level of [TNF alpha] production in PMA treated cells . Positive_regulation TNF IL1B 1421015 202096 Similarly recombinant [TNF alpha] alone *induced* synthesis only in a few U-937 cells . Positive_regulation TNF IL1B 14566449 1165122 mediates endotoxin- and [tumor necrosis factor] alpha *induced* RGS16 protein expression in cultured cardiac myocytes . Positive_regulation TNF IL1B 1460280 206640 This study was undertaken to further elucidate the mechanisms underlying TNF-alpha gene expression in the astrocyte , and to determine the intracellular signaling pathways involved in IFN-gamma/LPS and/or *induction* of the [TNF-alpha] gene . Positive_regulation TNF IL1B 1460280 206642 Two protein kinase C ( PKC ) inhibitors , H7 and staurosporine , abrogate IFN-gamma/LPS- and *induced* [TNF-alpha] expression in a dose dependent manner . Positive_regulation TNF IL1B 14611111 1162783 NGF down-regulates *induced* [TNF-alpha] and iNOS production by OA synovial fibroblasts . Positive_regulation TNF IL1B 14630536 1170464 Six hours after irradiation , levels had increased in the hypothalamus , thalamus and hippocampus , and [TNFalpha] and IL-6 levels had *increased* significantly in the hypothalamus . Positive_regulation TNF IL1B 15050606 1229429 *induces* [tumor necrosis factor alpha (TNF-alpha)] expression on mouse myeloid multipotent cell line 32D cl3 and inhibits their proliferation . Positive_regulation TNF IL1B 15103492 1258354 *induced* [TNF] production was greater in children compared with adults ( 2152+/-166 vs. 592+/-188 , P < 0.05 ) . Positive_regulation TNF IL1B 15103492 1258357 In conclusion , *induced* IL-6 and [TNFalpha] production were greater in pediatric than adult PMs . Positive_regulation TNF IL1B 15201199 1295547 The [TNFalpha] was secreted by amnion and choriodecidua in the presence of LPS or GBS , and stimulation with GBS *induced* a greater synthesis of than did stimulation with LPS . Positive_regulation TNF IL1B 1530600 200039 However , PCR by using cDNA prepared from interleukin-1 beta (IL-1 beta) stimulated RPE cells revealed expression of the gene , suggesting in vivo production of [TNF-alpha] from RPE cells in *response* to . Positive_regulation TNF IL1B 15390091 1354422 In addition , treatment of astrocytes with WIN55,212-2 downregulated in a concentration dependent manner *induced* [tumor necrosis factor (TNF)-alpha] release . Positive_regulation TNF IL1B 15456740 1342012 However , H2O2 , [tumor necrosis factor-alpha (TNF-alpha)] , and significantly *increased* NF-kappaB activation and expression of IL-8 compared with control cells . Positive_regulation TNF IL1B 15597792 1346557 [TNF] augments inflammation , TNF and IFN-gamma induce coagulation , and *induces* coagulation and fibrinolysis . Positive_regulation TNF IL1B 15672633 1350772 IL-1alpha and mRNA expression increased significantly ( p < 0.05 vs. sham-injury ) after severe TBI and IL-6 and [TNFa] mRNA expression *increased* significant ( p < 0.05 vs. sham-injury ) after both moderate and severe TBI . Positive_regulation TNF IL1B 15683451 1370618 The lymph node homing chemokine receptor CCR-7 expression was induced by TNF-alpha + + IL-6 + prostaglandin E2 but was not *induced* by Poly I:C + [TNF-alpha] . Positive_regulation TNF IL1B 15804596 1390933 A. actinomycetemcomitans clearly *induced* interleukin (IL)-6 , , and to a minimal extent , [tumor necrosis factor (TNF)-alpha] mRNA expression . Positive_regulation TNF IL1B 16024789 1435411 Overexpression of IRAK1c suppressed NF-kappaB activation and blocked *induced* IL-6 as well as lipopolysaccharide- and CpG induced [tumor necrosis factor] alpha production in multiple cellular systems . Positive_regulation TNF IL1B 16118510 1454361 *stimulated* IL-8 and MCP-1 mRNA at 6 h . [TNF-alpha] stimulated IL-8 and MCP-1 mRNA expression at 1 .5 and 3 h. alpha-MSH ( 10 ( -14 ) to 10 ( -10 ) M ) inhibited IL-8 and MCP-1 mRNA expression in the cells stimulated with IL-1beta or TNF-alpha . Positive_regulation TNF IL1B 1639861 194748 *induction* of [TNF-alpha] gene expression : involvement of protein kinase C . Positive_regulation TNF IL1B 1639861 194749 In the human astroglioma cell line CH235-MG , *induces* transcriptional activation of the [tumor necrosis factor-alpha (TNF-alpha)] gene , resulting in expression of TNF-alpha mRNA and biologically active TNF-alpha protein . Positive_regulation TNF IL1B 1639861 194750 This study was undertaken to elucidate intracellular signaling pathways involved in *induction* of the [TNF-alpha] gene . Positive_regulation TNF IL1B 1639861 194751 Two PKC inhibitors , H7 and staurosporine ( SS ) , abrogated *induced* [TNF-alpha] expression in a dose dependent fashion . Positive_regulation TNF IL1B 1639861 194752 Taken together , these data demonstrate that *induces* [TNF-alpha] gene expression in CH235-MG cells in a PKC dependent manner . Positive_regulation TNF IL1B 16459052 1534531 TAK1 downregulation reduces *induced* expression of MMP13 , MMP1 and [TNF-alpha] . Positive_regulation TNF IL1B 16499573 1528905 When infected HeLa cells were co-cultured with THP-1 cells , IL-6 and IL-8 secretion was sustained , expression followed a bell shaped curve and IL-10 , IL-12p70 and [TNF-alpha] synthesis was down *regulated* . Positive_regulation TNF IL1B 16565381 1538930 JNK activity is necessary for the *induction* of MMP-9 and [TNFalpha] by IL-1alpha , , or Jun in TM cells . Positive_regulation TNF IL1B 1660018 171370 Twenty-four-hour conditioned medium from lipopolysaccharide stimulated peripheral blood monocytes and nonparenchymal human liver cells enriched for Kupffer cells induced a time dependent increase in interleukin-8 messenger RNA levels in SK-hepatoma cells over a 24-hr period , similar to that seen for [tumor necrosis factor-alpha] or *induction* of interleukin-8 in primary hepatocytes . Positive_regulation TNF IL1B 16616208 1582985 The expression of IL-1beta , IL-8 , and [TNF-alpha] markedly increased in the *presence* of after day 14 of culture . Positive_regulation TNF IL1B 16684367 1663362 Incubation of human macrophages with NBD peptides resulted in 50 % inhibition of *induced* [TNF-alpha] production in the supernatant ( p < 0.01 ) . Positive_regulation TNF IL1B 16806199 1580420 [Tumor necrosis factor-alpha] and *increases* CTRP1 expression in adipose tissue . Positive_regulation TNF IL1B 16888805 1672718 Here , we show that and TPA *stimulated* [TNFalpha] gene transcription in hepatoma cells mediated by a composite TPA-responsive element/cAMP response element . Positive_regulation TNF IL1B 16888805 1672720 Both and TPA *triggered* phosphorylation and activation of the basic region leucine zipper transcription factors c-Jun and ATF2 and expression of dominant negative mutants of c-Jun and ATF2 reduced TNFalpha promoter activity and secretion of [TNFalpha] . Positive_regulation TNF IL1B 17022949 1641520 Relative to saline administration , *increased* IL1beta , [TNFalpha] and IL6 mRNAs in the nucleus tractus solitarius (NTS) , hypothalamus , hippocampus and somatosensory cortex ( SSctx ) , but did not induce any changes in IL10 . Positive_regulation TNF IL1B 17022949 1641530 In the amygdala , *enhanced* IL6 mRNA and [TNFalpha] increased IL1beta mRNAs . Positive_regulation TNF IL1B 17022949 1641531 In the insular cortex , *enhanced* IL6 mRNA and [TNFalpha] increased IL1beta mRNA . Positive_regulation TNF IL1B 17049356 1724420 Application of CTS for only 1 or 2h during a 24h incubation with IL-1beta was sufficient to inhibit *induced* upregulation of [TNF-alpha] , TNFR2 , and iNOS . Positive_regulation TNF IL1B 17058806 1636895 alone significantly *induced* IL-12 production in DCs , whereas [TNF-alpha] or IFN-gamma induced modest levels of IL-12 production . Positive_regulation TNF IL1B 17255557 1732931 Remicade , an anti-TNF-alpha antibody , markedly suppressed IL-1beta induced up-regulation of bradykinin B ( 1 ) and B ( 2 ) receptors , suggesting that TNF-alpha was involved in the up-regulation , which is further supported by the fact that *enhanced* [TNF-alpha] mRNA expression in the tracheae . Positive_regulation TNF IL1B 17295604 1725898 The data are consistent with a *role* for [TNF-alpha] , and possibly for , in mediating increased bone resorption during estrogen deficiency in women . Positive_regulation TNF IL1B 1732280 181435 *induction* of [tumor necrosis factor-alpha] gene expression in human astroglioma cells . Positive_regulation TNF IL1B 1732280 181437 Nuclear run-off analysis demonstrates that *causes* transcriptional activation of the [TNF-alpha] gene , and CHX enhances IL-1 beta induced TNF-alpha transcription . Positive_regulation TNF IL1B 1732280 181438 These results indicate that , a cytokine present in the central nervous system during some pathological disease states , is a potent *inducer* of [TNF-alpha] in human malignant glioma cells . Positive_regulation TNF IL1B 17328963 1726377 Human [TNF-alpha] *induced* the expression of IP-10 mRNA in porcine endothelial cells , while both human IFN-gamma and human failed . Positive_regulation TNF IL1B 1739130 182039 Both displayed a time- and dose dependent increase in steady-state levels of IL-8 mRNA in *response* to and [TNF-alpha] . Positive_regulation TNF IL1B 17484771 1778187 LPS induced production of [tumour necrosis factor-alpha (TNF-alpha)] , interleukin-6 (IL-6) , IL-10 and interferon-gamma-inducible protein-10 (IP-10); SA *induced* TNF-alpha , and production ; Positive_regulation TNF IL1B 17509446 1745172 When PBMC were cultured with a2NTD , there was a 2.5-fold increase in IL1A and gene expression and no *induction* of [TNF] gene expression . Positive_regulation TNF IL1B 17525069 1767228 Accordingly , hCG-A diminished *induced* [TNF-alpha] transcript levels and protein release measured by quantitative real-time PCR and enzyme linked immunosorbent assay . Positive_regulation TNF IL1B 17650656 1775972 No IL-1beta and [TNF-alpha] were *detected* in the synovia in control group , while in the other 3 groups , synovia and TNF-alpha levels increased significantly . Positive_regulation TNF IL1B 17848581 1817820 These inhibitors selectively target Tpl2 in these cells , and they block LPS- and *induced* [TNFalpha] production in both primary human monocytes and human blood . Positive_regulation TNF IL1B 17907382 1803276 while in comparison with model group , PGE2 and IL-1beta levels in EA-post-treatment group , level in IND group decreased significantly ( P < 0.05 ) , and [TNF-alpha] level in IND group *increased* significantly. No significant differences were found between model group and Rofecoxib and EA-pre-treatment groups in most time-courses of the hind-paw-volume , between model and IND , Rofecoxib and EA-pre-treatment groups in PGE2 , between model and EA-pre-treatment groups in IL-1beta , and between model and Rofecoxib , EA-pre-treatment and EA-post-treatment groups in TNF-alpha contents ( P > 0.05 ) . Positive_regulation TNF IL1B 17940116 1849339 Compared with basal outputs by DCs incubated with E2 , [TNF-alpha] enhanced MMP-1 and MMP-3 secretion by 14 +/- 3- and 9 +/- 2-fold , respectively , and *increased* MMP-1 and MMP-3 secretion by 13 +/- 3- and 19 +/- 2-fold , respectively ( P < 0.05 ) . Positive_regulation TNF IL1B 18081851 1903363 Furthermore , we show that the Mnk inhibitor CGP57380 is capable of inhibiting the phosphorylation of eIF4E in keratinocytes , and that the abolishment of eIF4E phosphorylation dramatically decreases the anisomycin induced protein release of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) , IL-1beta and IL-6 as well as the *induced* protein release of [TNF-alpha] . Positive_regulation TNF IL1B 18239058 1877022 Human pancreatic periacinar myofibroblasts expressed IL-32alpha in *response* to , [TNF-alpha] , and IFN-gamma . Positive_regulation TNF IL1B 18276934 1911666 Excess decidual cell expressed matrix metalloproteinases ( MMPs ) 2 and 9 , in *response* to preeclampsia related and [tumor necrosis factor alpha (TNF)] , may inappropriately degrade these basement membrane proteins and impede EVT invasion . Positive_regulation TNF IL1B 18372240 1888325 Caspase-3 activity was *increased* by and the pro-inflammatory cytokine combination , and to a lesser extent by [TNFalpha] . Positive_regulation TNF IL1B 18467203 1921439 *stimulated* NF-kappaB via a non-canonical pathway ( p52/p65 ) and [TNF-alpha] via the canonical pathway ( p50/p65 ) . Positive_regulation TNF IL1B 18475493 209557 The PDE-IV inhibitors caused a concentration dependent inhibition of [TNF-alpha] production , but only partially *inhibited* at high concentrations . Positive_regulation TNF IL1B 18621749 1954373 In addition , CORM-2 inhibited *induced* [TNF-alpha] but enhanced IL-1Ra production . Positive_regulation TNF IL1B 18760623 1975409 After 48 h , [TNF-alpha] also *induced* a significant increase in , IL-3 , and IP-10 secretion . Positive_regulation TNF IL1B 18786965 1976021 On the other hand , [TNF-alpha] and IL-17 did not *induce* RANKL expression , although TNF-alpha , IL-17 or stimulated cell growth and IL-6 production . Positive_regulation TNF IL1B 19008124 2041478 Functional analysis of miR-9 , miR-98 and miR-146 in primary chondrocytes suggests a role in mediating the *induced* production of [TNF-alpha] . Positive_regulation TNF IL1B 1918980 168437 We have previously demonstrated that Il-1 and [TNF] could rapidly , but transiently , *induce* gene expression of in human polymorphonuclear leukocytes ( PMN ) at both the protein and mRNA level . Positive_regulation TNF IL1B 1918980 168441 Using nuclear run-on transcription analysis , we found that within 1 h Il-1 , [TNF] , and TNF plus Il-1 *induced* the transcription of the gene by 33- , 61- , and 99-fold , respectively . Positive_regulation TNF IL1B 19503841 2091978 Secretion of IL-8 from Hela cells infected with C. trachomatis was not dependent on and [TNF- alpha] *induction* . Positive_regulation TNF IL1B 19712723 2158130 Interestingly , treatment with EP2 antagonist AH-6809 resulted in suppression of hypoxia *induced* EP2 , and iNOS mRNA and protein expression , [TNF-alpha] protein expression and intracellular cAMP level in BV-2 cells . Positive_regulation TNF IL1B 19940926 2167647 Importantly , Nestin-Cre and GFAP-Cre rank ( floxed ) deleter mice are resistant to lipopolysaccharide induced fever as well as fever in *response* to the key inflammatory cytokines and [TNFalpha] . Positive_regulation TNF IL1B 20419825 2246673 On day 1 after infection , the secretion of both [TNF-alpha] and IL-6 decreased significantly in the bronchoalveolar lavage fluid prepared from RSV infected offspring exposed to DBDE perinatally , but *increased* . Positive_regulation TNF IL1B 20589530 2296350 Engagement of SIGNR1 on PEMs with an anti-SIGNR1-specific rat IgM antibody , ERTR9 , *induced* production of IL-12 and [tumor necrosis factor (TNF)-alpha] from PEMs , while secretion of IL-6 and was not detected with the same treatment . Positive_regulation TNF IL1B 20600535 2316081 This study was conducted to evaluate the efficacy of luteolin in regulating *induced* production of MMPs ( MMP-1 and -3 ) and cytokines ( [tumor necrosis factor (TNF)-alpha] and IL-6 ) in human synovial cell line , SW982 . Positive_regulation TNF IL1B 2109008 131122 IFN-gamma and alone do not *induce* [TNF-alpha] production , however , the combined treatment of IFN-gamma and IL-1 beta results in a striking synergistic effect on astrocyte TNF-alpha production . Positive_regulation TNF IL1B 2171355 142457 The TNF infusions did not produce detectable circulating nor did they *induce* significant production of [TNF] or IL-1 beta by circulating blood monocytes . Positive_regulation TNF IL1B 2212667 142733 In the present study , we demonstrate that human peripheral blood PMN produce IL-1 beta in *response* to IL-1 alpha , , and [TNF-alpha] . Positive_regulation TNF IL1B 2221137 142841 These data support the hypotheses that is responsible for a significant part of LPS fever and that [TNF] *acts* as an endogenous antipyretic to limit the magnitude of LPS fever in the rat . Positive_regulation TNF IL1B 22651847 2643590 Furthermore , we observed rapid [tumor necrosis factor-a] and gene *induction* in conventional primary astrocyte cultures after IL-6 stimulation , which was due to the activation of the Janus kinase/signal transducer and activator of the transcription pathway in contaminating microglia . Positive_regulation TNF IL1B 23034253 2684498 In the present study , we examined the effect of a marine bioactive compound containing high-purity caviar derived DNA , collagen elastin and protein extracts from sturgeon ( LD-1227 , Caviarlieri , Laboratoires Dom , Switzerland ) on *induced* activation and production of [TNFalpha] and MMP-13 in human osteo-arthritis ( OA ) chondrocytes and intracellular signaling factors . Positive_regulation TNF IL1B 23034253 2684502 LD-1227 significantly decreased *stimulated* gene expression and production of [TNFalpha] , MMP-1 , MMP-13 and Col10A1 in human chondrocytes . Positive_regulation TNF IL1B 2334910 132667 The *induction* of [TNF] and interleukin 1 beta (IL-1 beta) mRNA by exogenous TNF or , as determined by Northern blot analysis , is time dependent in normal human monocytes isolated by countercurrent elutriation . Positive_regulation TNF IL1B 2547724 115635 In contrast to other cell types , eosinophils are unique in their differential *responses* to and [TNF] . Positive_regulation TNF IL1B 3494060 72247 Induction with TNF resulted in the appearance of IL 1-alpha mRNA and a very significant increase in IL 1-beta mRNA , indicating that [TNF] *induces* the synthesis of both IL 1-alpha and in FS-4 cells . Positive_regulation TNF IL1B 7617302 315392 Furthermore , also *induced* increases in [TNF alpha] and c-fos mRNAs . Positive_regulation TNF IL1B 7670776 322592 In addition , clinical improvement was associated with decreased synthesis of IL-1 beta , [TNF-alpha] and IL-8 *induced* by bacterial lipopolysaccharide , IL-1 alpha and in PBMC in vitro . Positive_regulation TNF IL1B 7687636 222484 *induced* IL-1 alpha and [TNF-alpha] were reduced by 84 % ( p = 0.01 ) and 68 % ( p < 0.001 ) , respectively . Positive_regulation TNF IL1B 7710416 298013 While was detected in all of the GCF samples studied , [TNF-alpha] could only be *detected* in about half the samples . Positive_regulation TNF IL1B 7840168 293834 ZG cells released IL-6 and [TNF] , and this release was *stimulated* by lipopolysaccharide , interleukin-1 alpha , , a protein kinase C activator , and a calcium ionophore without affecting intracellular adenosine 3 ' , 5'-cyclic monophosphate ( cAMP ) content . Positive_regulation TNF IL1B 8032000 263996 From these experiments it is suspected that neuroglial cell derived [TNF-alpha] *induced* by of IFN-gamma may participate in local immune reactions of the brain in an autocrine and paracrine fashion . Positive_regulation TNF IL1B 8032545 264021 There was no increase in serum TNF-alpha or and no consistent in vitro *induction* of [TNF-alpha] or IL-1 beta from monocytes posttreatment . Positive_regulation TNF IL1B 8179914 256086 Given that mononuclear phagocytes can produce both the proinflammatory cytokines IL-1 alpha , , and TNF-alpha as well as the suppressive cytokine IL-1ra , we proposed that IL-1 alpha , IL-1 beta , and [TNF-alpha] may *induce* IL-1ra from mononuclear phagocytes . Positive_regulation TNF IL1B 8391053 224154 There was a significant increase of mRNA levels ( unstimulated cells ) on days 1 and 7 , but [TNF-alpha] mRNA levels *increased* significantly on day 1 only . Positive_regulation TNF IL1B 8544101 338861 IL-1 beta activation of GF cells showed that non only *induces* the expression of IL-6 , IL-8 and [TNF-alpha] , but also acts in an autocrine manner of GF cells and induces IL-1 beta expression . Positive_regulation TNF IL1B 8544101 338865 Pretreatment of GF cells with IL-1 beta resulted in the enhanced synthesis of [TNF-alpha] in *response* to additional . Positive_regulation TNF IL1B 8580368 337502 Captopril dose-dependently suppressed the *induced* synthesis of [TNF] by 74 % ( P < 0.01 ) and the IL-1 beta induced synthesis of IL-1 alpha by 60 % ( P < 0.01 ) . Positive_regulation TNF IL1B 8627304 355866 Whereas activation of protein kinase A was able to induce expression of the IL-6 gene , it did not induce TNF alpha gene expression and was not involved in *induced* IL-6 and [TNF alpha] gene expression . Positive_regulation TNF IL1B 8638287 342966 IL-2 , IL-6 , IL-8 , [TNF-alpha] , TNF-beta and IFN-gamma , but not IL-1 alpha , were *detected* in the monkey using human reagents . Positive_regulation TNF IL1B 8663179 368393 Interleukin-8 (IL-8) , a potent neutrophil chemotactic peptide that elicits pleiotropic biological effects is secreted in large amounts by normal human osteoblastic and bone marrow osteoprogenitor stromal ( HBMS ) cells in *response* to and [tumor necrosis factor-alpha] . Positive_regulation TNF IL1B 8840155 386690 The data provide evidence for an in vivo *role* for epidermal IL-1 alpha , and TNF-alpha transcription in the regulation of IL-1 beta and [TNF-alpha] polypeptide levels in the epidermis in response to this common contact allergen . Positive_regulation TNF IL1B 8933165 398162 Meanwhile , DY-9973 did not inhibit *induced* [TNF-alpha] production in U937 cells . Positive_regulation TNF IL1B 8933165 398163 [TNF-alpha] production *induced* by LPS or was similarly inhibited by treatment with herbimycin , a tyrosine kinase inhibitor . Positive_regulation TNF IL1B 8964827 366118 There also was a trend towards decreased expression of the alpha 6 subunit in *response* to interleukin-1 alpha , , and [tumor necrosis factor-alpha] . Positive_regulation TNF IL1B 8973628 403052 During normoxia , LPS was the most potent stimulus , inducing the release of each cytokine , while fMLP showed a less pronounced effect on IL-8 and production and markedly *inhibited* [TNF-alpha] production . Positive_regulation TNF IL1B 9013629 411737 Here we show that a tissue-type TGase is expressed in rat brain astrocytes in vitro , and is *induced* by the inflammation associated cytokines and to a lesser extent by [tumor necrosis factor-alpha] . Positive_regulation TNF IL1B 9025720 405836 Diminished GH receptor mRNA concentrations in *response* to and [TNF-alpha] indicate that low IGF-I levels during severe illness , despite high circulating GH levels , may at least partially be a consequence of suppression of hepatic GH receptor synthesis by IL-1 beta and TNF-alpha . Positive_regulation TNF IL1B 9029133 413590 in contrast , their levels of , IL-4 , and IFN-gamma were normal and their levels of IL-2 and [TNF-alpha] were marginally *increased* . Positive_regulation TNF IL1B 9038369 415550 [TNF-alpha] rapidly *induced* Mn-SOD gene expression while was a strong but slow inducer of this gene . Positive_regulation TNF IL1B 9053967 345088 Although and IFN-gamma mRNA were detected in most specimens , IL-2 , IL-3 , IL-4 , IL-5 , IL-9 , [TNF-alpha] , and IFN-beta mRNA were not *detected* at all . Positive_regulation TNF IL1B 9089293 421816 However , treatment with cycloheximide did not prevent *stimulated* release of [TNF-alpha] , indicating that the cytokine can regulate TNF-alpha secretion at a posttranslational level , independently of TNF-alpha mRNA induction . Positive_regulation TNF IL1B 9115637 423511 This increase in CDS activity also leads to increased secretion of [tumor necrosis factor-alpha] and interleukin-6 from endothelial ECV304 cells upon *stimulation* with , suggesting that CDS overexpression may amplify cellular signaling responses from cytokines . Positive_regulation TNF IL1B 9126707 426584 LPS- and *stimulated* adrenal [TNF] release was inhibited by adenosine . Positive_regulation TNF IL1B 9166282 432332 Maximum levels of [TNF alpha] and IL-8 were *detected* at 2 hours after LPS-injection , whereas and IL-1 receptor antagonist (IL-1Ra) were detected at 6 and 9 hours , respectively . Positive_regulation TNF IL1B 9166282 432336 These results provide new evidence that IL-8 as well as [TNF alpha] are the most proximal cytokines and *induce* subsequent production of and IL-1Ra . Positive_regulation TNF IL1B 9302075 453947 *induced* modulation of the hypothalamic IL-1beta system , [tumor necrosis factor-alpha] , and transforming growth factor-beta1 mRNAs in obese ( fa/fa ) and lean ( Fa/Fa ) Zucker rats : implications to IL-1beta feedback systems and cytokine-cytokine interactions . Positive_regulation TNF IL1B 9302075 453948 *increased* IL-1beta , IL-1 receptor types I and II ( IL-1RI and IL-1RII ) , IL-1 receptor accessory protein soluble form ( IL-1R AcP II ) , IL-1 receptor antagonist (IL-1Ra) , [TNF-alpha] , and TGF-beta1 mRNAs in the hypothalamus from obese and lean rats . Positive_regulation TNF IL1B 9366717 463331 and [TNF-alpha] gene *induction* was assessed by quantitative competitive reverse-transcription polymerase chain reaction and cytokine protein production was determined by enzyme linked immunosorbent assay . Positive_regulation TNF IL1B 9609762 508759 Mesenchymal cells dose-dependently proliferated in *response* to , IL-6 , and [TNF-alpha] . Positive_regulation TNF IL1B 9705247 525872 Supernatant from TPV infected cells significantly decreased the [TNF-alpha] but not *induced* expression of these molecules . Positive_regulation TNF IL1B 9764841 537434 Therefore , the ability of IL-1alpha or to *induce* epidermal cell production of [TNF alpha] was assessed . Positive_regulation TNF IL1B 9833249 552019 Out data showed that IL-1 beta , but not [TNF-alpha] , *induces* an increase in NGF levels , while concomitant injection of both cytokines enhances the effect of on NGF presence . Positive_regulation TNF IL1B 9877451 557310 We studied effects of diverse drugs on the formation of immunoreactive TNF-alpha in the human hepatoma cell lines HepG2 and Hep3B , in which [TNF-alpha] production was *induced* by treatment ( 3 h incubation periods ) with ( IL-1beta , 300 pg/ml ) or phorbol myristate acetate ( PMA , 100 nmol/l ) . Positive_regulation TNF IL1B 9877451 557311 Pentoxifylline ( 1 mg/ml ) did not influence PMA induced TNF-alpha production , but it augmented *induced* [TNF-alpha] production . Positive_regulation TNF IL1B 9879839 557890 The hypothesis is that *induces* the production by keratinocytes of [tumour necrosis factor alpha (TNF-alpha)] which acts in a paracrine fashion on LC to provide one signal for migration . Positive_regulation TNF IL1R1 11170718 783677 As in astrocytes , IL-1 and [TNF alpha] *induced* expression of . Positive_regulation TNF IL1R1 21115691 2357908 We show that is *essential* for TLR9 dependent activation of [tumor necrosis factor] receptor associated factor 3 ( TRAF3 ) and for production of the antiinflammatory cytokines IL-10 and type I interferon ( IFN ) . Positive_regulation TNF IL1R1 9000676 410145 blockade *reduces* [tumor necrosis factor] production , tissue injury , and mortality after hepatic ischemia-reperfusion in the rat . Positive_regulation TNF IL1R2 9000676 410146 blockade *reduces* [tumor necrosis factor] production , tissue injury , and mortality after hepatic ischemia-reperfusion in the rat . Positive_regulation TNF IL1RN 1533322 186449 alone at concentrations as high as 1 microgram/mL did not *induce* IL-1 alpha , IL-1 beta , [TNF alpha] , or IL-6 synthesis . Positive_regulation TNF IL1RN 15627643 1349325 Generally , Co nanoparticles had an overall pro-inflammatory effect on naive macrophages , by reducing anti-inflammatory and *inducing* inflammatory [TNF-alpha] . Positive_regulation TNF IL1RN 22886741 2719753 Interestingly , levels remained always significantly lower than normally reported levels , and [TNF-a] levels did not *increase* after trauma . Positive_regulation TNF IL1RN 3040855 77465 In contrast , human recombinant [tumor necrosis factor] , which shares some of the biologic activities of IL-1 , is not *inhibited* by the urinary . Positive_regulation TNF IL1RN 7882594 298878 The leukocyte infiltration was largely *mediated* by both [TNF alpha] and IL-1 and could be divided into at least two phases : the early ( within 3 hr ) phase which was partly inhibited by anti-TNF alpha , but not by IL-1ra , and the late phase ( 4-12 hr ) mediated by both TNF alpha and IL-1 , and largely inhibited synergistically with anti-TNF alpha and . Positive_regulation TNF IL1RN 8132734 251601 Lipopolysaccharide (LPS) , granulocyte/macrophage colony stimulating factor ( GM-CSF ) , and [tumor necrosis factor-alpha (TNF-alpha)] , individually , transiently *increased* IL-1ra steady-state mRNA levels in PMN , with associated increases in protein synthesis . Positive_regulation TNF IL1RN 8179914 256087 Given that mononuclear phagocytes can produce both the proinflammatory cytokines IL-1 alpha , IL-1 beta , and TNF-alpha as well as the suppressive cytokine , we proposed that IL-1 alpha , IL-1 beta , and [TNF-alpha] may *induce* IL-1ra from mononuclear phagocytes . Positive_regulation TNF IL1RN 8179914 256094 In contrast to mononuclear phagocytes , IL-1 alpha , IL-1 beta , and [TNF-alpha] did not *induce* further production in alveolar macrophages . Positive_regulation TNF IL1RN 8331299 223598 [Tumor necrosis factor-alpha] *induces* interleukin-1 alpha and production by cultured human keratinocytes . Positive_regulation TNF IL1RN 9166282 432333 Maximum levels of [TNF alpha] and IL-8 were *detected* at 2 hours after LPS-injection , whereas IL-1 beta and were detected at 6 and 9 hours , respectively . Positive_regulation TNF IL1RN 9166282 432337 These results provide new evidence that IL-8 as well as [TNF alpha] are the most proximal cytokines and *induce* subsequent production of IL-1 beta and . Positive_regulation TNF IL1RN 9564808 500746 In contrast , spontaneous release of IL-1alpha , IL-1ra , GM-CSF , and [TNF-alpha] was *increased* in the supernatants of unstimulated keratinocytes from patients with AD compared with keratinocytes from control subjects , with and GM-CSF reaching statistically significant difference . Positive_regulation TNF IL1RN 9753045 533796 In patients ' sera , [tumour necrosis factor (TNF)-alpha] , interleukin (IL)-10 , IL-12 , neopterin , macrophage-colony stimulating factor ( M-CSF ) , and *increased* , whereas GM-CSF and granulocyte-colony stimulating factor ( G-CSF ) decreased after an initial peak . Positive_regulation TNF IL2 10504438 648914 Both GM-CSF and [TNF-alpha] *induced* the migration of human Langerhans cells in vitro , whereas IL-1beta , , IL-10 , IL-12 , and IFN-gamma had no effect on Langerhans cell migration . Positive_regulation TNF IL2 10683986 478637 As compared with pre-operative values , levels in both groups decreased significantly ( P < 0.05 ) , and the levels of sIL-2R , IL-6 , [TNF-alpha] , and IL-10 in both groups *increased* significantly at multiple time points post-operative ( P < 0.01 ) . Positive_regulation TNF IL2 10706460 579323 Our results indicated that given subcutaneously at a low dose of 100 microg/day for 3 weeks *induced* IFN-gamma and [TNF-alpha] in plasma ( measured 24 hrs after the last dose of IL-2 ) and affected the ability of blood leukocytes to produce cytokines . Positive_regulation TNF IL2 11089907 751502 Moreover , LPS- or *increased* the levels of [TNF-alpha] and NOx in the supernatants of AH-130 cell and macrophage co-culture , although LPS and IL-2 did not induce TNF-alpha and NOx production by AH-130 cells incubated without macrophages . Positive_regulation TNF IL2 11521964 852608 CLA supplementation did not alter the in vitro secretion of prostaglandin E2 , leukotriene B4 , interleukin-1beta (IL-1beta) , or [tumor necrosis factor alpha (TNFalpha)] by PBMC simulated with lipopolysaccharide , and the secretion of by PBMC *stimulated* with phytohemagglutinin . Positive_regulation TNF IL2 12165278 972799 *had* no effect on IL-6 or [TNF] production by PBMCs isolated from any group in the presence or absence of bacterial lipopolysaccharide (LPS) . Positive_regulation TNF IL2 12414777 1011163 During the acute phase , IFN-gamma and [TNF-alpha] *induced* increases in , sIL-2R , IL-10 , and sCD30 levels in serum , which allowed the development of immunity characterized by the nonreactivity of the HBV surface antigen , the onset of antibodies to the HBV surface antigen ( anti-HBs ) , and normal alanine aminotransferase levels during the convalescent phase . Positive_regulation TNF IL2 1327287 197651 Weak expression of specific [TNF-alpha] transcripts was *detected* at resting conditions and on unstimulated cells , whereas both or anti-CD3 MoAb induced TNF-alpha mRNA . Positive_regulation TNF IL2 1353987 192644 *induces* [tumor necrosis factor-alpha] production by activated human T cells via a cyclosporin-sensitive pathway . Positive_regulation TNF IL2 1353987 192647 Anti-CD3 induced TNF-alpha production could be inhibited by blocking the IL-2R with a combination of anti-Tac and Mik beta 1 ( mAbs against the p55 and p75 chain of the IL-2R respectively ) thus indicating an essential *role* of in [TNF-alpha] induction . Positive_regulation TNF IL2 1373169 183255 Time course of the *induced* [TNF] production revealed an initial TNF-alpha production , whereas significant levels of TNF-beta were detected after 72 h . Positive_regulation TNF IL2 1394436 198876 AG126 and AG183 enhanced [TNF-alpha] secretion and this effect was more prominent in the *presence* of . Positive_regulation TNF IL2 1429368 202647 IFN-gamma and [TNF-alpha] are induced upon CD3 but not CD2 stimulation , both in the *presence* and absence of . Positive_regulation TNF IL2 1516257 196785 Peripheral blood mononuclear cells ( PBMC ) from untreated patients produced IL-1 beta , [tumour necrosis factor-alpha (TNF-alpha)] and IL-6 in *response* to mitogenic stimulation with phytohaemagglutinin ( PHA ) , only low levels of IL-1 beta , and TNF-alpha in response to OvAg , but higher amounts of IL-4 and interferon-gamma (IFN-gamma) in response to OvAg than control individuals . Positive_regulation TNF IL2 15381112 1298605 ERBA did not affect , IL-3- , and GCSF dependent cell growth , or [tumor necrosis factor] alpha *induced* growth suppression , nor did ERBA affect osteoclast formation induced by IL-11 , leukemia inhibitory factor , and 1alpha,25-dihydroxyvitamin D ( 3 ) . Positive_regulation TNF IL2 15517620 1328649 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL2 15652945 1364375 IEL cytokine mRNA expression was also significantly altered with TPN : and IL-10 expression declined , and IL-4 IL-6 , interferon gamma (IFN-gamma) , transforming growth factor beta-1 ( TGF-beta1 ) , and [tumor necrosis factor-alpha (TNF-alpha)] were *increased* , when compared with Control or TPN+Food mice . Positive_regulation TNF IL2 1598496 188835 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL2 1611281 191045 CK-M stimulated thioglycollate *induced* peritoneal macrophages to produce interleukin 1 (IL-1) and [tumor necrosis factor alpha (TNF-alpha)] at concentrations of 1-100 ng/ml , and it also induced and interferon-gamma (IFN-gamma) as well as IL-6 production by splenocytes . Positive_regulation TNF IL2 16154177 1475731 In contrast , *stimulated* [TNF-alpha] and IL-6 production was not affected by age . Positive_regulation TNF IL2 1627494 191741 Both IL-4 and IL-10 [ cytokine synthesis inhibitory factor ( CSIF ) ] inhibit *induced* synthesis of IFN-gamma and [tumor necrosis factor (TNF)-alpha] by human PBMC . Positive_regulation TNF IL2 1641784 194832 Because has limited direct effects on neutrophils and acutely *induces* the production of [tumor necrosis factor-alpha (TNF)] , we hypothesized that the acute microvascular alterations and hemodynamic instability induced by IL-2 were mediated by TNF . Positive_regulation TNF IL2 16444302 1495521 In III and IV stages of prostate cancer the levels of were very low and the levels of IL-6 and [TNF-alpha] were very *increased* . Positive_regulation TNF IL2 1696166 137209 In conjunction with IL-2 , cytokines such as IFN-alpha , IFN-gamma , or TNF did not interfere with *induction* of [TNF] and LT mRNA . Positive_regulation TNF IL2 1696166 137212 Interestingly , IL-4 in combination with IL-2 inhibited the *induction* of [TNF] and LT mRNA . Positive_regulation TNF IL2 1696166 137213 In particular , they reveal the previously unrecognized function of IL-4 in antagonizing the *induction* of [TNF] , LT , and Tac mRNA in PBMC . Positive_regulation TNF IL2 1700275 143302 RNA processing is a limiting step for murine [tumor necrosis factor] beta expression in *response* to . Positive_regulation TNF IL2 1700275 143304 We have previously reported that [tumor necrosis factor beta (TNF beta)] expression is *induced* by in the murine lymphocytic T-cell line CTLL-2 . Positive_regulation TNF IL2 1717551 166822 Low levels of TNF were produced in response to IL-7 at day 5 , as opposed to a 50-fold higher [TNF] production in *response* to . Positive_regulation TNF IL2 17523134 1762096 This reduction was dose and time dependent , suggesting a regulatory *role* of in [TNF] secretion that might occur at the post-transcriptional level . Positive_regulation TNF IL2 1756531 174378 Endogenous interferon alpha/beta produced by Kupffer cells inhibits interleukin-1 , [tumor necrosis factor] alpha production and induced *activation* of nonparenchymal liver cells . Positive_regulation TNF IL2 18097033 1847477 Ectopic expression of NFATc2 but not NFATc1 , especially its short isoform , *enhanced* [TNF-alpha] synthesis in human T cells at the gene transcription level , whereas both NFATs augmented expression . Positive_regulation TNF IL2 1837110 175090 *increased* [TNF-alpha] production and was more effective under normal conditions ( 10 to 15 fold increase ) than during rejection episodes ( 1.3 to 2.4 fold ) . Positive_regulation TNF IL2 1901829 155909 IL-4 acts as a homeostatic regulator of *induced* [TNF] and IFN-gamma . Positive_regulation TNF IL2 1901829 155913 *induced* high levels of [TNF] and IFN-gamma secretion in both groups . Positive_regulation TNF IL2 1901829 155916 [TNF] levels *induced* by were similarly reduced by IL-4 both in normal donors ( P less than 0.003 ) and in patients ( P less than 0.01 ) . Positive_regulation TNF IL2 1902846 156094 On the other hand , [TNF alpha] plus IFN gamma *induced* TEC HLA-DR expression on both types of thyroid xenografts at death , although alone did not induce HLA-DR expression , and IFN gamma induced TEC significantly only on normal thyroid xenografts ( but not on Graves ' xenografts ) . Positive_regulation TNF IL2 1906383 161715 GM-CSF , and TNF-alpha directly *induced* the production of cell associated IL-1 but little or no IL-1 or [TNF-alpha] secretion . Positive_regulation TNF IL2 1906383 161723 GM-CSF did not enhance [TNF-alpha] secretion *induced* by or TNF-alpha . Positive_regulation TNF IL2 1906383 161725 In contrast , synergistically *enhanced* [TNF-alpha] secretion induced by IFN-gamma . Positive_regulation TNF IL2 1937586 170358 *induces* [tumor necrosis factor] gene expression in vivo . Positive_regulation TNF IL2 1937586 170360 We therefore examined the hypothesis that *induces* [TNF] gene expression in vivo . Positive_regulation TNF IL2 1947446 171260 Many of the side effects of IL-2 immunotherapy are due to *induced* synthesis of [tumour necrosis factor-alpha (TNF-a)] and can be alleviated by co-administration of steroids . Positive_regulation TNF IL2 19568710 2104588 The level of CD3 ( + ) , CD4 ( + ) , the ratio of CD4 and CD8 ( + ) , IgA , IgM , IgG and decreased in patients with NSCLC on day 1 after operation , and the level of CD8 and [TNF-alpha] *increased* compared to pre-operation . Positive_regulation TNF IL2 1959936 172587 Gamma interferon ( gamma-IFN ) , lipopolysaccharide (LPS)-gamma or *induced* [tumor necrosis factor alpha (TNF alpha)] production by both macrophages and peripheral blood mononuclear cells ( PBMC ) , was increased in the presence of neopterin . Positive_regulation TNF IL2 1972165 135331 IL-2 and IL-4 were both growth promoting for human T cells but only could efficiently *induce* [TNF] production . Positive_regulation TNF IL2 19762486 2168299 Stimulation of CD56+ cells containing both DCs and abundant gammadelta T cells with zoledronate and *resulted* in the rapid expansion of gammadelta T cells as well as in IFN-gamma , [TNF-alpha] , and IL-1beta but not in IL-4 , IL-10 , or IL-17 production . Positive_regulation TNF IL2 2004026 154676 *Induction* of [TNF] by may also contribute to subsequent acceleration of myelopoiesis by initiation of GM-CSF mRNA synthesis in patient marrow fibroblasts . Positive_regulation TNF IL2 2015630 156771 FAC stimulates the production of [TNF-alpha] and IFN-gamma in human PBM , and this effect is *potentiated* by . Positive_regulation TNF IL2 21113640 2407574 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL2 2113076 135521 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL2 2113430 135574 In addition to suppression of LAK induction , IL-4 also inhibits *induced* IFN-gamma and [TNF-alpha] protein production in PBMC . Positive_regulation TNF IL2 21150712 2366393 By using multiparameter flow cytometry , the quantities of IL-12 needed to prime naive antigen-reactive T cells to simultaneously produce interferon-? and [tumor necrosis factor-a] in the *presence* or absence of secretion in conjunction with lytic activity defined by CD107a expression can be used to determine the overall potency of a DC product . Positive_regulation TNF IL2 2119428 141810 We report here that [tumour necrosis factor (TNF)alpha] , gamma-interferon and can , in some circumstances , *increase* fetal resorption rates in abortion-prone ( CBA/J x DBA/2 ) and non-abortion prone ( CBA/J x BALB/c , C3H x DBA/2 ) matings : 1000 units TNF enhanced resorptions from 43 to 79 % in CBA x DBA/2 , from 7 to 89 % in CBA x BALB/c , from 5 to 47 % in C3H x DBA/2 . Positive_regulation TNF IL2 2120581 141923 Therefore , we investigated the effect of interferon-alpha (IFN-alpha) , IFN-gamma and tumor necrosis factor ( TNF-alpha ) on the induction of LAK activity by , and the *induction* of IFN-gamma and [TNF-alpha] by IL-2 . Positive_regulation TNF IL2 2139787 131391 Plasma tumor necrosis factor-alpha (TNF-alpha) levels , but not interferon-gamma (IFN-gamma) levels , increased during IL-2 treatment , but spontaneous and *stimulated* [TNF-alpha] secretion in vitro remained abnormally low . Positive_regulation TNF IL2 2144468 140066 We examined cytokine production by IL-2 treated , nonmonocytic PBMC and found that a population of nonadherent low-density cells ( NLDC ) produced both IL-1 beta and [TNF alpha] in *response* to . Positive_regulation TNF IL2 2147201 145429 The lymphokines IL-2 and IL-4 promoted the growth of human PHA triggered T cells , but only *induced* the production of IFN-gamma and [TNF] . Positive_regulation TNF IL2 2147201 145431 IL-6 did not influence IFN-gamma or [TNF] production or T cell proliferation *induced* by and did not modulate IL-1 induced IFN-gamma production . Positive_regulation TNF IL2 2160321 133276 Studies of cytokine receptor expression indicated that OKT3 plus plus TNF *caused* an earlier up-regulation of the IL-2 receptor beta chain (Tac) and higher [TNF] receptor expression by day 6 compared to 100 units/ml IL-2 alone . Positive_regulation TNF IL2 21871585 2510359 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL2 2242421 144855 Inhibition of *induced* [tumor necrosis factor] release by dexamethasone : prevention of an acquired neutrophil chemotaxis defect and differential suppression of interleukin-2 associated side effects . Positive_regulation TNF IL2 2242421 144856 To determine if dexamethasone can exert a similar suppressive effect on *induced* [TNF] synthesis in vivo , the concentration of TNF alpha was measured in plasma samples serially obtained ( a ) from cancer patients participating in a phase I dose escalation clinical trial with high-dose IL-2 administered in conjunction with dexamethasone ( IL-2/Dex ) and ( b ) from patients participating in concurrent studies with IL-2 alone . Positive_regulation TNF IL2 2242421 144858 They further suggest that the altered spectrum and reduced severity of IL-2 side effects observed in patients receiving dexamethasone may be attributable in part to the suppressive effect of steroids on *induced* [TNF] synthesis . Positive_regulation TNF IL2 22870498 2641392 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL2 22995521 2689019 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL2 2308780 129969 The [IL-2/TNF] driven generation of LAK activity *involves* the induction of high affinity receptors on LGL and occurs without promoting a significant proliferation , suggesting a functional activation rather than a proliferative expansion of LAK precursors . Positive_regulation TNF IL2 2334896 132664 In vitro pretreatment of macrophages with IL-4 largely abolished their ability to synthesize [TNF] in *response* to or lipopolysaccharide . Positive_regulation TNF IL2 23702712 2792426 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL2 2404745 128016 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL2 2471522 111731 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL2 2493195 107965 The studies demonstrate that interleukin 1 (IL-1) , [tumor necrosis factor (TNF)] , gamma-interferon ( IFN ) , and *increase* the adherence of T-lymphocytes to fibroblasts in a dose- and time dependent manner . Positive_regulation TNF IL2 2504308 115258 In vivo *induction* of gamma interferon and [tumor necrosis factor] by infusion following intensive chemotherapy or autologous marrow transplantation . Positive_regulation TNF IL2 2504681 117040 Of the TG-15-I and TG-15-II , the former stimulates higher production whereas the latter *enhances* IFN-gamma and [TNF] production . Positive_regulation TNF IL2 2661690 114472 The results of these in vivo studies suggest that may be a physiologic *inducer* of [TNF] and IL-6 which , because of their pleiotropic effects , may be important endogenous signals in the body 's immune response and account for some of the physiologic changes seen in patients receiving high dose IL-2 . Positive_regulation TNF IL2 2783642 106911 *induced* [tumor necrosis factor-alpha (TNF-alpha)] gene expression in human alveolar macrophages and blood monocytes . Positive_regulation TNF IL2 2783642 106914 AM phi [TNF-alpha] biologic activity from nine subjects was 110 +/- 28 ( *mediated* ) and 304 +/- 69 ( LPS mediated ) U/ml/10 ( 6 ) cells , which represented 2- and 6-fold increases over controls . Positive_regulation TNF IL2 2783642 106916 AM phi exhibited statistically greater ( p less than 0.05 ) [TNF] production in *response* to both and LPS as compared to PBM . Positive_regulation TNF IL2 2785134 111494 [TNF-alpha] *induces* the expression of and promotes the proliferation and differentiation of T and B cells . Positive_regulation TNF IL2 3011946 59733 [Tumor necrosis factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL2 3045826 97117 Specific binding of 125I labeled [TNF] to LGL was *increased* by stimulation . Positive_regulation TNF IL2 3075075 104121 It was shown that [TNF alpha] *induced* receptor expression on CD16 ( + ) cells alone and even more in combination with Il-2 . Positive_regulation TNF IL2 3121358 81608 Additionally we found that alone was *sufficient* to induce [TNF] in these cells when they had been precultured with phytohemagglutinin for 7 days to express IL 2 receptors . Positive_regulation TNF IL2 3121359 81609 Recombinant [tumor necrosis factor] can *induce* receptor expression and cytolytic activity in a rat x mouse T cell hybrid . Positive_regulation TNF IL2 3121359 81611 Here we show that highly purified recombinant [TNF] , in combination with interleukin 2 (IL2) , can *induce* receptor expression and cytolytic activity in a rat x mouse T cell hybrid ( PC60 ) . Positive_regulation TNF IL2 3138005 97307 We also demonstrate that *induced* an increase of specific [TNF] binding to LGL . Positive_regulation TNF IL2 3147435 102771 *Induction* of [tumor necrosis factor-alpha] and -beta and interferon-gamma mRNA by in murine lymphocytic cell lines . Positive_regulation TNF IL2 3260265 94476 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL2 3486936 60075 [Tumor necrosis factor] ( cachectin ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL2 3526909 62625 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL2 7536712 300181 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL2 7583927 333590 In LPL , there was no SEE induced or IL-4 production , but IL-6 , [TNF] , and gamma interferon were *induced* . Positive_regulation TNF IL2 7648444 318924 In control subjects , MP and were strong *inducers* of IFN-gamma , IL-1 beta , [TNF-alpha] , and GM-CSF mRNA expression , but only MP was able to induce considerable levels of IL-6 and IL-2 mRNA expression . Positive_regulation TNF IL2 7804532 284669 *induced* release of [TNF-alpha] was dramatically reduced by IL-10 ; Positive_regulation TNF IL2 7994039 283060 These results indicate ( 1 ) that IL-2 and [TNF] receptors are related to each other on leukemic cells in B-CLL and ( 2 ) that the is *involved* in the regulation of other structures , ie , CSF receptors , thus pointing to another functional role of this receptor complex and the related cytokine in leukemic cells . Positive_regulation TNF IL2 8064221 268849 Finally , [TNF-alpha] production in *response* to and sCD23 precedes IFN-gamma and IFN-gamma secretion is significantly inhibited by anti-TNF-alpha mAb , indicating that the sCD23 costimulatory signal for IFN-gamma production may be partially mediated by TNF-alpha release . Positive_regulation TNF IL2 8097322 217607 We demonstrate that IFN-gamma production from SCID splenocytes is stimulated by interleukin (IL) 12 , tumor necrosis factor alpha (TNF-alpha) , and but is inhibited by IL-10 , IL-10 , IL-12 , and [TNF] are *induced* by heat killed Listeria monocytogenes ( hk-LM ) from SCID splenocytes and peritoneal macrophages . Positive_regulation TNF IL2 8132326 251499 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL2 8132735 251612 *mediated* secretion of [TNF-alpha] by the free cells was inhibited by PTX . Positive_regulation TNF IL2 8170078 255082 Thus , the present study failed to demonstrate the involvement of a direct action of [TNF-alpha] , *activation* of immunological cells by or its direct action as an anti-tumor effect of intravesical instillation of BCG . Positive_regulation TNF IL2 8174177 242823 Interestingly , rhIL-10 dose-dependently inhibited the production of IFN-gamma and [TNF-alpha] *induced* by , but had no effects on PBMC proliferation and generation of LAK activity . Positive_regulation TNF IL2 8230465 235829 We have recently demonstrated that tumor necrosis factor alpha (TNF-alpha) and downregulate the hepatic steady-state content of hepatitis B virus ( HBV ) mRNA in vivo in HBV-transgenic mice and that the IL-2 effect is *mediated* by [TNF-alpha] . Positive_regulation TNF IL2 8302298 248784 In these transfectants , CD28 mAbs , similarly to CD3 mAbs , were able to induce Ca2+ mobilization , promoter *induction* ( measured as beta-galactosidase activity in T cells hybridomas pre transfected with the IL-2-lac Z reporter gene ) , IL-2 secretion , [TNF alpha] production and apoptosis ( observed as growth arrest and genome fragmentation ) . Positive_regulation TNF IL2 8333833 223718 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL2 8370177 229453 These findings suggest that IL-6 and [TNF-alpha] will *induce* up-regulation/IL-2 secretion via the induction of IL-1 beta production . Positive_regulation TNF IL2 8381194 210360 *enhances* the production of [tumor necrosis factor-alpha] in activated B-type chronic lymphocytic leukemia ( B-CLL ) cells . Positive_regulation TNF IL2 8381194 210361 A moderate increase in [TNF-alpha] secretion was also *induced* by TPA or alone . Positive_regulation TNF IL2 8381194 210363 IL-4 did not have any major effects on the production of TNF-alpha in activated cells , but inhibited the *induced* production of [TNF-alpha] in SAC activated cells . Positive_regulation TNF IL2 8409382 233330 3 ) [TNF] *induces* direct thymocyte apoptosis ( a property not shared by IL-1 beta , , IL-4 , IL-6 and IL-7 ) . Positive_regulation TNF IL2 8436829 213069 *Activation* of [tumor necrosis factor-alpha] production from human neutrophils by via IL-2-R beta . Positive_regulation TNF IL2 8436829 213071 The *induction* of [TNF-alpha] and functional activation of neutrophils by is therefore an important immunomodulatory property of IL-2 that has not heretofore been recognized . Positive_regulation TNF IL2 8564962 349076 PCR revealed that significantly *induced* [TNF] mRNA expression in the liver . Positive_regulation TNF IL2 8592105 341944 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL2 8592432 350683 We sought to determine if the antitumor effect of combined is *mediated* by [TNF alpha] . Positive_regulation TNF IL2 8592432 350684 These data demonstrate significantly increased TNF alpha levels in mice treated with combined therapy and abrogation of the antitumor effect of WBHT+IL-2 therapy by the addition of anti-TNF alpha Ab with a tumor growth rate similar to that observed in untreated mice , suggesting that the antitumor effect of is *mediated* at least in part by [TNF alpha] . Positive_regulation TNF IL2 8622948 354718 Exogenous , which restitutes the proliferative response of the anti-CD3- and anti-CD28 treated Rel-/- T cells , *restores* production of IL-5 , [TNF-alpha] , and IFN-gamma , but not IL-3 and GM-CSF expression to approximately normal levels . Positive_regulation TNF IL2 8699123 372921 Interleukin-10 inhibits *induced* [tumor necrosis factor] production but does not reduce toxicity in C3H/HeN mice . Positive_regulation TNF IL2 8699123 372925 However , IL-10 did inhibit *induced* increases in serum [TNF-alpha] , which was accompanied by a decrease in Golgi apparatus and rough endoplasmic reticulum in alveolar macrophages . Positive_regulation TNF IL2 8926285 386357 IFN-alpha activated the secretion of IFN-gamma only , whereas *activated* the secretion of both [TNF-alpha] and IFN-gamma by the binder and killer subsets and secretion was augmented by the addition of K562 to the cultures . Positive_regulation TNF IL2 9018238 412195 In contrast , *induced* significantly lower [TNF-alpha] production in either cell-contact dependent or direct culture , and IL-8 and MIP-1 alpha were ineffective . Positive_regulation TNF IL2 9272775 450594 Production of interleukin (IL)-1beta , IL-6 and [tumour necrosis factor (TNF)-alpha] were *induced* with lipopolysaccharides (LPS) , and that of and interferon (IFN)-gamma with staphylococcal enterotoxin B (SEB) and phytohaemagglutinin ( PHA ) . Positive_regulation TNF IL2 9346915 459564 In this cell line ( EL4D6/76 ) , [tumor necrosis factor] *induced* ligand/receptor internalization , NFkappaB nuclear translocation , production , and the activation of neutral (N)-SMase and acid ( A ) -SMase . Positive_regulation TNF IL2 9504629 491273 Mitogenic stimulation with phorbol 12-myristate 13-acetate ( PMA ) or PMA plus *resulted* in a tremendous increase in [TNF-alpha] and IL-6 production in cells representing early stage ( Binet A ) disease . Positive_regulation TNF IL2 9548401 498863 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL2 9607578 508526 however , no effect on *induced* IL-8 induction , or on the IL-1beta- or IL-2 induced [tumor necrosis factor] production , was observed . Positive_regulation TNF IL2 9657919 516880 IL-1beta and [TNF-alpha] synergistically *induced* IL-6 and GM-CSF and additively induced IL-8 and MCP-1 production , while , IL-10 , IFN-alpha , and IFN-gamma had little or no additional effects . Positive_regulation TNF IL2 9659158 517170 Conversely , antibody to [TNF-alpha] reduced IEL proliferation in *response* to or IL-7 . Positive_regulation TNF IL2 9679667 520849 Transgenic expression of cytokines in beta-cells of non-diabetes-prone mice and NOD mice has suggested pathogenic roles for IFN alpha , IFN gamma , and IL-10 in insulin dependent diabetes mellitus ( IDDM ) development , and protective *roles* for IL-4 , IL-6 and [TNF alpha] . Positive_regulation TNF IL2 9753244 533887 Live H. pylori *induced* production of many cytokines , such as IL-1beta , IL-10 , IL-8 , IFN-gamma , and [TNF-alpha] , whereas we could not detect or IL-4 . Positive_regulation TNF IL20 15517620 1328650 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL20 1598496 188836 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL20 18758357 1956630 Enzyme linked immunosorbent assay , analysis also showed that combined with IL-1beta *up-regulated* the secretion of [TNF-alpha] , IL-6 , IL-8 , and MCP-1 . Positive_regulation TNF IL20 19830738 2168901 Like IL-22 , IL-17A and [TNF-alpha] *induced* in keratinocytes , whereas IFN-gamma and IL-20 itself did not . Positive_regulation TNF IL20 21113640 2407575 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL20 2113076 135522 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL20 21871585 2510360 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL20 22870498 2641393 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL20 22995521 2689020 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL20 23002091 2698027 In vitro , *promoted* [TNF-a] , IL-1ß , MCP-1 , CCR4 , and CXCR4 and increased proliferation , migration , reactive oxygen species ( ROS ) production , and colony formation of oral cancer cells via activated STAT3 and AKT/JNK/ERK signals . Positive_regulation TNF IL20 23702712 2792427 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL20 2404745 128017 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL20 2471522 111732 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL20 24763901 2950200 also *increased* TGF-ß1 , [tumor necrosis factor (TNF)-a] , and type I collagen ( Col-I ) expression , and promoted the proliferation and migration of activated HSCs . Positive_regulation TNF IL20 3011946 59734 Tumor necrosis [factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL20 3260265 94477 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL20 3486936 60076 Tumor necrosis factor ( [cachectin] ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL20 3526909 62626 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL20 7536712 300182 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL20 8132326 251500 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL20 8333833 223719 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL20 8592105 341945 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL20 9548401 498864 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL21 15517620 1328651 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL21 1598496 188837 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL21 20974986 2348724 Sustained IL-18 signals resulted in IL-13 and GM-CSF production , whereas IL-12 and *induced* IL-10 and [TNF-a] . Positive_regulation TNF IL21 21113640 2407576 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL21 2113076 135523 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL21 21871585 2510361 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL21 22870498 2641394 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL21 22995521 2689021 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL21 23702712 2792428 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL21 2404745 128018 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL21 2471522 111733 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL21 3011946 59735 [Tumor necrosis factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL21 3260265 94478 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL21 3486936 60077 [Tumor necrosis factor] ( cachectin ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL21 3526909 62627 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL21 7536712 300183 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL21 8132326 251501 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL21 8333833 223720 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL21 8592105 341946 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL21 9548401 498865 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL22 15517620 1328634 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL22 1598496 188820 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL22 21113640 2407559 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL22 2113076 135506 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL22 21871585 2510344 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL22 22870498 2641377 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL22 22995521 2689004 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL22 23702712 2792411 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL22 2404745 128000 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL22 2471522 111716 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL22 3011946 59718 Tumor necrosis [factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL22 3260265 94461 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL22 3486936 60060 Tumor necrosis factor ( [cachectin] ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL22 3526909 62610 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL22 7536712 300166 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL22 8132326 251484 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL22 8333833 223703 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL22 8592105 341929 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL22 9548401 498848 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL23A 16549049 1537876 also *promoted* the production of Th1 cytokines such as IFN-gamma , IL-12 and [TNF-alpha] . Positive_regulation TNF IL23A 16830103 1586768 Finally , isolated Kupffer cells produced [TNFalpha] in *response* to , but not IL-12 , suggesting that IL-23 may be the relevant initiator of the hepatic inflammatory response to ischemia/reperfusion . Positive_regulation TNF IL23A 17619881 1815989 [TNF-alpha] *induced* MIP-3alpha but not production in cultured synovial cells from RA patients . Positive_regulation TNF IL23A 17641010 1771209 The mature DC ( CD83 ( + ) CD70 ( + ) HLA-DR ( high ) CD14 ( low ) ) expressed high levels of mRNA for IL-6 , IL-15 , and , *induced* naive CD4 T cells to produce IFN-gamma and [TNF-alpha] , and stimulated resting CD4 T cells to secret IL-17 . Positive_regulation TNF IL23A 24683394 2931401 IL-12 and , by influencing the naïve lymphocytes T and stimulating their diversification towards Th1 and Th17 , also , indirectly , *cause* an increase in [TNF-a] and other cytokines production ( IL-2 , IFN-? , IL-17 , IL-10 , IL-22 ) . Positive_regulation TNF IL24 15517620 1328632 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL24 1598496 188818 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL24 21113640 2407557 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL24 2113076 135504 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL24 21871585 2510342 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL24 21902545 2491817 The results suggested that the abilities of to *induce* IL-6 , [TNF-a] , and IFN-? production were higher than wtmda-7/IL-24 . Positive_regulation TNF IL24 22870498 2641375 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL24 22995521 2689002 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL24 23702712 2792409 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL24 2404745 127998 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL24 2471522 111714 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL24 3011946 59716 Tumor necrosis [factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL24 3260265 94459 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL24 3486936 60058 Tumor necrosis factor ( [cachectin] ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL24 3526909 62608 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL24 7536712 300164 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL24 8132326 251482 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL24 8333833 223701 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL24 8592105 341927 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL24 9548401 498846 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL25 15517620 1328633 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL25 1598496 188819 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL25 21113640 2407558 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL25 2113076 135505 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL25 21871585 2510343 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL25 22870498 2641376 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL25 22995521 2689003 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL25 23702712 2792410 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL25 2404745 127999 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL25 2471522 111715 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL25 3011946 59717 [Tumor necrosis factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL25 3260265 94460 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL25 3486936 60059 [Tumor necrosis factor] ( cachectin ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL25 3526909 62609 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL25 7536712 300165 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL25 8132326 251483 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL25 8333833 223702 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL25 8592105 341928 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL25 9548401 498847 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL26 15517620 1328638 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL26 1598496 188824 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL26 21113640 2407563 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL26 2113076 135510 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL26 21871585 2510348 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL26 22870498 2641381 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL26 22995521 2689008 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL26 23055831 2685184 Results show that *induces* the production of the proinflammatory cytokines IL-1-beta , IL-6 , and [tumor necrosis factor (TNF)-alpha] by human monocytes and also upregulates the expression of numerous chemokines ( mainly CCL20 ) . Positive_regulation TNF IL26 23702712 2792415 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL26 2404745 128004 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL26 2471522 111720 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL26 3011946 59722 Tumor necrosis [factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL26 3260265 94465 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL26 3486936 60064 Tumor necrosis factor ( [cachectin] ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL26 3526909 62614 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL26 7536712 300170 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL26 8132326 251488 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL26 8333833 223707 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL26 8592105 341933 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL26 9548401 498852 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL27 15517620 1328639 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL27 1598496 188825 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL27 21113640 2407564 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL27 2113076 135511 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL27 21871585 2510349 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL27 22870498 2641382 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL27 22995521 2689009 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL27 23702712 2792416 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL27 2404745 128005 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL27 2471522 111721 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL27 3011946 59723 [Tumor necrosis factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL27 3260265 94466 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL27 3486936 60065 [Tumor necrosis factor] ( cachectin ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL27 3526909 62615 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL27 7536712 300171 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL27 8132326 251489 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL27 8333833 223708 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL27 8592105 341934 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL27 9548401 498853 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL2RA 12014650 941639 In contrast , during the 18- to 36-hours interval , [SL-TNF-alpha] *induced* significantly higher ( p < 0.05 ) leukoctyte , T cell , and NK cell numbers , basal leukocyte proliferation , and activation marker expression ; Positive_regulation TNF IL2RA 16720206 1565274 Modulation of cytokine release through humanized monoclonal antibodies was moderate and selective : *led* to increased release of IL-2 and reduced production of [TNFalpha] , whereas anti-CD3 decreased release of interferon-y and IL-5 and increased secretion of IL-10 . Positive_regulation TNF IL2RA 8977306 403214 Furthermore , IL-12 up-regulated TNF receptors on gammadelta T cells in vitro : [TNF-alpha] binding to its receptor *induced* expression on the gammadelta T cells in an autocrine or paracrine fashion , or perhaps both . Positive_regulation TNF IL3 10713329 675933 like GM-CSF , *augmented* the expression and secretion of [TNF] but did not prime for further expression and secretion of TNF in response to LPS . Positive_regulation TNF IL3 10713329 675935 Neither GM-CSF or *increased* the expression or secretion of [TNF receptor p55 (TNF-Rp55)] , although both agents increased expression of TNF receptor p75 (TNF-Rp75) . Positive_regulation TNF IL3 15381112 1298606 ERBA did not affect IL-2- , , and GCSF dependent cell growth , or [tumor necrosis factor] alpha *induced* growth suppression , nor did ERBA affect osteoclast formation induced by IL-11 , leukemia inhibitory factor , and 1alpha,25-dihydroxyvitamin D ( 3 ) . Positive_regulation TNF IL3 15517620 1328652 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL3 1598496 188838 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL3 16455967 1522316 We have found that stimulation of bone marrow cells *induces* the production of [TNF] via a PI3K- and MAPK kinase/ERK dependent pathway . Positive_regulation TNF IL3 16455967 1522318 The importance of *induced* [TNF] secretion was demonstrated by the failure of TNF-deficient bone marrow cells to survive for > 3 wk when cultured in IL-3 and SCF , a defect that was reversed by the addition of soluble TNF . Positive_regulation TNF IL3 18760623 1975410 After 48 h , [TNF-alpha] also *induced* a significant increase in IL-1beta , , and IP-10 secretion . Positive_regulation TNF IL3 1885210 165697 We have studied the production of interleukin-1 (IL-1) , interleukin-6 (IL-6) and [tumor necrosis factor (TNF)] by mouse peritoneal macrophages triggered by lipopolysaccharide (LPS) in the *presence* or absence of . Positive_regulation TNF IL3 21113640 2407577 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL3 2113076 135524 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL3 2120130 141879 alone *stimulated* monocyte u-PA activity , but not [TNF-alpha] or IL-1 activity . Positive_regulation TNF IL3 2120130 141882 However , , together with interferon-gamma (IFN-gamma) , *stimulated* the [TNF-alpha] , but not IL-1 , activities of monocytes from several donors . Positive_regulation TNF IL3 21871585 2510362 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL3 22870498 2641395 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL3 22995521 2689022 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL3 2364439 136667 Kinetic studies of IL-1 induced IL-3 production indicated that 4-6 days of culture were required for optimal production , whereas 1-2 days were sufficient in cultures stimulated with concanavalin A. Recombinant IL-6 failed to induce significant amounts of IL-3 , and [TNF alpha] *induced* only weak production . Positive_regulation TNF IL3 23702712 2792429 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL3 2404745 128019 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL3 2471522 111734 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL3 3011946 59736 Tumor necrosis [factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL3 3260265 94479 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL3 3486936 60078 Tumor necrosis factor ( [cachectin] ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL3 3526909 62628 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL3 7536712 300184 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL3 7545455 318546 [Tumor necrosis factor] alpha *induced* up-regulation of receptor mRNA expression in a CD34 positive hematopoietic cell line . Positive_regulation TNF IL3 8132326 251502 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL3 8333833 223721 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL3 8399069 230686 In vitro studies of IL-3 treated normal alveolar macrophage and monocyte population demonstrated that significantly *augmented* [TNF] and IL-6 secretion in monocytes , but not in alveolar macrophages . Positive_regulation TNF IL3 8592105 341947 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL3 9548401 498866 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL31 15517620 1328640 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL31 1598496 188826 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL31 21113640 2407565 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL31 2113076 135512 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL31 21871585 2510350 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL31 22870498 2641383 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL31 22995521 2689010 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL31 23702712 2792417 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL31 2404745 128006 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL31 2471522 111722 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL31 3011946 59724 Tumor necrosis [factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL31 3260265 94467 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL31 3486936 60066 Tumor necrosis factor ( [cachectin] ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL31 3526909 62616 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL31 7536712 300172 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL31 8132326 251490 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL31 8333833 223709 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL31 8592105 341935 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL31 9548401 498854 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL32 15517620 1328637 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL32 15664165 1365194 Although IL-32 does not share sequence homology with known cytokine families , *induces* various cytokines , human [TNFalpha] , and IL-8 in THP-1 monocytic cells as well as mouse TNFalpha and MIP-2 in Raw macrophage cells . Positive_regulation TNF IL32 1598496 188823 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL32 16410314 1513719 Furthermore , *induces* production of [tumor necrosis factor] , macrophage inflammatory protein (MIP)-2 and IL-8 in monocytic cell lines , indicating that this factor would be involved in the inflammatory responses . Positive_regulation TNF IL32 17078892 1663552 Interestingly , [TNFalpha] reciprocally *induced* mRNA expression in T cells , monocyte derived dendritic cells , and synovial fibroblasts . Positive_regulation TNF IL32 21113640 2407562 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL32 2113076 135509 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL32 21381070 2431810 In vitro , IL-1ß and [TNF-a] significantly *induced* expression in human Huh-7.5 cells . Positive_regulation TNF IL32 21871585 2510347 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL32 21899560 2524731 Production of was *induced* by IFN-? , [TNF] , and dsRNA in primary airway epithelial cells . Positive_regulation TNF IL32 22336080 2576428 is *induced* by IFN-? , [TNF-a] , T(H)1 cells , and rhinovirus in bronchial epithelial cells . Positive_regulation TNF IL32 22870498 2641380 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL32 22995521 2689007 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL32 23242112 2718615 was *induced* by IFN-? , [TNF-a] , dsRNA , and incubation with Th1 cells in primary nasal epithelial cells . Positive_regulation TNF IL32 23702712 2792414 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL32 2404745 128003 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL32 2471522 111719 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL32 3011946 59721 Tumor necrosis [factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL32 3260265 94464 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL32 3486936 60063 [Tumor necrosis factor] ( cachectin ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL32 3526909 62613 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL32 7536712 300169 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL32 8132326 251487 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL32 8333833 223706 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL32 8592105 341932 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL32 9548401 498851 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL33 15517620 1328636 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL33 1598496 188822 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL33 21113640 2407561 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL33 2113076 135508 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL33 21871585 2510346 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL33 21968692 2507444 dose-dependently *enhanced* [TNF-a] and IL-6 productions by peripheral blood mononuclear cells ( PBMCs ) responding to lipopolysaccharide . Positive_regulation TNF IL33 22870498 2641379 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL33 22995521 2689006 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL33 23397250 2787073 We report that GMF induced IL-33 release , and that *augments* GMF induced [tumor necrosis factor-alpha] ( TNF-a ) release from mouse astrocytes . Positive_regulation TNF IL33 23397250 2787075 *induces* CCL2 , [TNF-a] and nitric oxide release through phosphorylation of ERK in mouse astrocytes . Positive_regulation TNF IL33 23528820 2827649 These results indicate the involvement of MCs in host defense at HSV infected sites through [TNF-a] and IL-6 production , which is *induced* by keratinocyte derived . Positive_regulation TNF IL33 23585867 2768711 significantly *stimulated* the production of inflammatory cytokines ( [TNF-a] , IL-1ß and IL-6 ) and chemokine IL-8 by HCECs at both mRNA and protein levels . Positive_regulation TNF IL33 23702712 2792413 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL33 23711851 2792845 However , synergistically *enhanced* IC-induced IL-8 and [TNF-a] production in SyMCs . Positive_regulation TNF IL33 2404745 128002 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL33 24459820 2884548 [TNF-alpha] and IFN-gamma *induce* expression of , and IL-33 produced by keratinocytes contributes to allergic contact dermatitis . Positive_regulation TNF IL33 2471522 111718 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL33 3011946 59720 Tumor necrosis [factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL33 3260265 94463 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL33 3486936 60062 Tumor necrosis factor ( [cachectin] ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL33 3526909 62612 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL33 7536712 300168 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL33 8132326 251486 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL33 8333833 223705 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL33 8592105 341931 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL33 9548401 498850 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL34 15517620 1328641 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL34 1598496 188827 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL34 21113640 2407566 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL34 2113076 135513 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL34 21181166 2499591 Among four inflammatory cytokines [ ( IL-1ß , IL-6 , IL-17 , and tumor necrosis factor-a (TNF-a) ] , mRNA expression level was dramatically *induced* by IL-1ß ( 17-fold ) and [TNF-a] ( 74-fold ) . Positive_regulation TNF IL34 21871585 2510351 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL34 22870498 2641384 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL34 22995521 2689011 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL34 23702712 2792418 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL34 2404745 128008 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL34 2471522 111723 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL34 3011946 59725 [Tumor necrosis factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL34 3260265 94468 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL34 3486936 60067 Tumor necrosis factor ( [cachectin] ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL34 3526909 62617 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL34 7536712 300173 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL34 8132326 251491 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL34 8333833 223710 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL34 8592105 341936 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL34 9548401 498855 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL36G 10744718 680703 However , could be *induced* in vitro in keratinocytes by interferon-gamma and [tumor necrosis factor-alpha] and in vivo via a contact hypersensitivity reaction or herpes simplex virus infection . Positive_regulation TNF IL37 15517620 1328635 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL37 1598496 188821 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL37 21113640 2407560 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL37 2113076 135507 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL37 21871585 2510345 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL37 22870498 2641378 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL37 22995521 2689005 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL37 23702712 2792412 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL37 2404745 128001 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL37 2471522 111717 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL37 3011946 59719 [Tumor necrosis factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL37 3260265 94462 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL37 3486936 60061 [Tumor necrosis factor] ( cachectin ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL37 3526909 62611 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL37 7536712 300167 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL37 8132326 251485 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL37 8333833 223704 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL37 8592105 341930 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL37 9548401 498849 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL4 10211885 607703 *had* no effect on [TNFalpha] up-regulation of NF-kappaB , and a slight decrease was noted with IL-10 and IL-13 at the highest concentration used ( 5 ng/ml ) . Positive_regulation TNF IL4 10606958 655871 Fluticasone also reversed the increase in both D1+ expression and [TNF-alpha] production *induced* by . Positive_regulation TNF IL4 10706724 673348 When cells were stimulated with [TNF-alpha] in the *presence* of , we observed enhanced P-selectin expression with a parallel reduction in E-selectin expression . Positive_regulation TNF IL4 11477201 841976 thus , to further clarify the differences of monocyte function and differentiation between neonates and adults , we investigated their CD14 ( + ) CD4 ( + ) and CD14 ( + ) CD16 ( + ) monocyte subpopulations , production of IL-1beta and [tumor necrosis factor-alpha] induced by lipopolysaccharide , and their CD14 and CD1a phenotypic changes in *response* to and granulocyte-macrophage colony stimulating factor . Positive_regulation TNF IL4 11505428 847924 *had* more consistent suppressive effect on [TNF-alpha] production . Positive_regulation TNF IL4 11943316 928689 The objectives of this study were to determine interleukin (IL)-1 beta , IL-2 , , IL-5 , IL-6 , IL-8 , IL-10 , interferon (IFN)-gamma and [tumor necrosis factor (TNF)-alpha] *induction* in bronchoalveolar lavage (BAL) of control horses and horses with heaves both during remission and exacerbation of the disease , and to determine the effect of therapy with inhaled fluticasone propionate on the cytokine profile of horses with heaves . Positive_regulation TNF IL4 11953039 930575 CMV stimulation *induced* [tumor necrosis factor-alpha (TNF-alpha)] and interferon-gamma (IFN-gamma) in both CD4 ( + ) and CD8 ( + ) cells ( usually together ) , with a shift from memory- to effector-cell phenotype , while only a small proportion of CD4 ( + ) cells produced . Positive_regulation TNF IL4 12244147 990521 In contrast , the production of IL-12 p70 , but not IL-10 and [TNF] , induced by microbial products was *enhanced* only by , not by IL-13 or Y119D , a selective type II IL-4R agonist , in vitro and in vivo . Positive_regulation TNF IL4 12663680 1074597 QS21 and CFA *induced* significant IFN-gamma , IL-4 and [tumor necrosis factor-alpha] expression , whereas alum induced primarily production . Positive_regulation TNF IL4 1315359 185445 together with IL-1 induced IgE secretion , and the IgE secretion was further *increased* by [TNF-alpha] . Positive_regulation TNF IL4 14638848 1176705 In this paper , we investigated the regulatory *role* of in [TNF-alpha] production in mast cells . Positive_regulation TNF IL4 14638848 1176712 Furthermore , induced the expression of tristetraprolin (TTP) , an RNA binding protein that promotes decay of ARE containing mRNA , in mast cells by a Stat6 dependent mechanism , and the depletion of TTP expression by RNA interference *prevented* IL-4 induced down-regulation of [TNF-alpha] production in mast cells . Positive_regulation TNF IL4 15517620 1328653 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL4 1552742 184178 Hairy cell leukemia (HCL) cells produced [TNF alpha] in the absence of stimuli and this production was markedly *enhanced* by addition of IFN alpha or , to a lesser extent , by IFN gamma and . Positive_regulation TNF IL4 15634596 1349533 In recovery SAA patients , the serum levels of [TNF-alpha] significantly decreased to ( 1.46 +/- 1.41 ) microg/L ( P < 0.01 ) , and the levels of *increased* markedly to ( 3.05 +/- 1.94 ) microg/L . Positive_regulation TNF IL4 1571090 187165 differentially *regulates* [tumor necrosis factor-alpha] gene expression by human T lymphocytes and monocytes . Positive_regulation TNF IL4 15866472 1402045 On the other hand , neutrophil depletion of susceptible BALB/c mice did not affect the expression of [TNF-alpha] and monocyte derived chemokine (MDC) in peritoneal macrophages but *induced* the early stage expression of in draining lymph node cells and exacerbated the footpad lesions and increased the parasite burden . Positive_regulation TNF IL4 1598496 188839 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL4 1651157 163041 *had* no effect on the growth-stimulatory activity of [TNF] on normal human foreskin fibroblasts . Positive_regulation TNF IL4 16776679 1573092 In addition , IFN-gamma , and IL-10 were elevated in SAC and VKC , while eotaxin and [TNF-alpha] were only *increased* in VKC . Positive_regulation TNF IL4 1690777 128485 IFN-gamma and [TNF-alpha] were essential to the killing mechanism whereas Il-1 , Il-2 , and were not *required* . Positive_regulation TNF IL4 1695647 137132 *regulates* endothelial cell activation by IL-1 , [tumor necrosis factor] , or IFN-gamma . Positive_regulation TNF IL4 17617590 1769628 and IL-13 negatively *regulate* [TNF-alpha-] and IFN-gamma induced beta-defensin expression through STAT-6 , suppressor of cytokine signaling (SOCS)-1 , and SOCS-3 . Positive_regulation TNF IL4 1905642 161636 First , both IFN-gamma and as single agents and in combination were potent *inducers* of [TNF-alpha] production by M phi infected with L. major amastigotes . Positive_regulation TNF IL4 1972165 135332 IL-2 and were both growth promoting for human T cells but only IL-2 could efficiently *induce* [TNF] production . Positive_regulation TNF IL4 20347489 2307334 IL-8 , IL-6 and [TNF-alpha] *increased* , and decreased during the challenge in both groups . Positive_regulation TNF IL4 20357482 2300397 Primary human kerarinocytes were stimulated with dsRNA in the *presence* of , IL-13 and [TNF-alpha] . Positive_regulation TNF IL4 20798517 2313708 [TNF] *increases* expression of and PARs in mast cells . Positive_regulation TNF IL4 21113640 2407578 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL4 2113076 135525 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL4 2119829 141851 The reduced secretion of IL-1 beta and [TNF alpha] was specifically *induced* by because anti-IL-4 antiserum completely restored normal monokine production . Positive_regulation TNF IL4 21871585 2510363 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL4 22249152 2559629 Stimulation of cultured T lymphocytes with *caused* elevated production of IFN-? , IL-10 , IL-6 , MCP-1 , and [TNF-a] , with notable differences between patients and controls in the production of IFN-? , IL-10 , and IL-6 . Positive_regulation TNF IL4 22870498 2641396 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL4 22995521 2689023 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL4 23586635 2772901 Moreover , pyriproxyfen induced higher titers of IgG2a and enhanced [tumor necrosis factor-alpha] and gamma-interferon responses whereas alum *induced* IgG1 with enhanced and -10 . Positive_regulation TNF IL4 23702712 2792430 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL4 2404745 128020 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL4 2471522 111735 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL4 24879793 2945827 IL-13Ra2 expression can be *induced* in lung fibroblasts by or IL-13 via a STAT6 dependent mechanism , or by [TNF-a] via a STAT6 independent mechanism . Positive_regulation TNF IL4 2495033 108062 Northern analysis of RNA from IL-4 induced and uninduced stromal cells indicated that did not upregulate expression of CSF-1 or transforming growth factor-beta ( TGF-beta ) and only modestly *increased* expression of [tumor necrosis factor] , suggesting that these cytokines were not responsible for the inhibitory activity . Positive_regulation TNF IL4 2677211 119477 Although B cells generally also produced TNF-alpha and TNF-beta upon stimulation , did not *induce* [TNF] secretion and seemingly had a specific effect on IL-6 production . Positive_regulation TNF IL4 2785566 111567 RNA hybridization studies demonstrated that does not *induce* transcription of IL-1 or [TNF] . Positive_regulation TNF IL4 3011946 59737 [Tumor necrosis factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL4 3260265 94480 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL4 3486936 60079 [Tumor necrosis factor] ( cachectin ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL4 3526909 62629 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL4 7536712 300185 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL4 7540642 310119 Seven-day cultured monocytes/macrophages showed ( 1 ) diminished [TNF-alpha] production in *response* to IL-10 but not ( 2 ) , diminished IL-1 beta production in response to both IL-4 and IL-10 , and compared with fresh monocytes ( 3 ) , diminished CD14 expression in response to IL-4 , and ( 4 ) a lesser increase in CD23 expression in response to IL-4 . Positive_regulation TNF IL4 7583927 333591 In LPL , there was no SEE induced IL-2 or production , but IL-6 , [TNF] , and gamma interferon were *induced* . Positive_regulation TNF IL4 7680648 211628 down-regulated and IFN gamma *enhanced* the [TNF alpha-] and IL-1 beta induced increase in RANTES mRNA , whereas the induction of IL-8 mRNA by TNF alpha or IL-1 beta was inhibited by IFN gamma and augmented by IL-4 . Positive_regulation TNF IL4 7689258 225736 Unexpectedly , rapamycin actually synergized with IL-4 in both the upregulation of CD23 expression and the down-regulation of the type II ( p75 ) TNF receptor , while in the same B cell line , rapamycin simultaneously inhibited the *dependent* production of [TNF alpha] and beta . Positive_regulation TNF IL4 7790026 313163 Because IL-10 and differentially *regulate* [TNF-alpha] and IL-1ra production by synovial fluid mononuclear cells , selective use of either IL-10 or IL-4 in the treatment of chronic inflammatory conditions will depend on whether TNF-alpha or IL-1 , respectively , is established as primarily responsible for the maintenance of the chronic inflammatory condition . Positive_regulation TNF IL4 8097934 217705 Furthermore , *induced* a slight increase in the IL-12 stimulated [TNF] production . Positive_regulation TNF IL4 8132326 251503 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL4 8218932 231782 *reduced* the number of p55 [TNF-R] on HeLa cells from 6400 ( Kd 5.1 nM ) to 3900 ( Kd 3.7 nM ) , and p75 TNF-R on Jijoye cells from 4800 ( Kd 1.6 nM ) to 3250 ( Kd 1.5 nM ) . Positive_regulation TNF IL4 8333833 223722 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL4 8363277 229154 Thus , TGF-beta , but not or IL-10 , can *induce* resting human monocytes to produce [TNF] , IL-1 , and IL-6 . Positive_regulation TNF IL4 8515073 221977 Our study indicated that endogenous production inhibited IL-10 secretion and , concomitantly , *increased* [TNF-alpha] and GM-CSF release . Positive_regulation TNF IL4 8592105 341948 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL4 8675208 369796 IFN-gamma and *increased* lipopolysaccharide (LPS) induced [TNF-alpha] , IL-1 steady-state message levels . Positive_regulation TNF IL4 8704096 371122 Our data demonstrate that IL-1 alpha and [TNF-alpha] release by AMs is down *regulated* by , IL-10 , and TGF-beta . Positive_regulation TNF IL4 8834369 386018 prevents mortality from acute but not chronic murine peritonitis and *induces* an accelerated [tumor necrosis factor-alpha] response . Positive_regulation TNF IL4 8871669 389626 Addition of an Ab to IL-10 suggested that the stimulatory effects of LPS on p75 [TNF] receptor expression were due , at least in part , to LPS stimulation of IL-10 production and that *acted* , in part , by decreasing IL-10 production . Positive_regulation TNF IL4 8894441 392381 The AD group demonstrated a significantly lower production of [TNF-alpha] and IFN-gamma compared with the two other groups , and and IL-5 production *increased* in the IA group . Positive_regulation TNF IL4 9029133 413591 in contrast , their levels of IL-1 beta , , and IFN-gamma were normal and their levels of IL-2 and [TNF-alpha] were marginally *increased* . Positive_regulation TNF IL4 9548401 498867 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL4 9753244 533888 Live H. pylori *induced* production of many cytokines , such as IL-1beta , IL-10 , IL-8 , IFN-gamma , and [TNF-alpha] , whereas we could not detect IL-2 or . Positive_regulation TNF IL4 9837907 552477 Wortmannin reversed the *induced* [TNF] receptor down-regulation and all other measured cellular responses , indicating a critical role of phosphatidylinositol 3-kinase . Positive_regulation TNF IL5 10725746 677670 *Activation* of HUVEC by IL-1beta or [TNF-alpha] or priming of eosinophils by both promote CCR3 dependent migration of eosinophils from the vasculature in conjunction with CCR3-active chemokines . Positive_regulation TNF IL5 15517620 1328654 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL5 1598496 188840 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL5 18598175 1935338 The [TNF-alpha] , IFN-gamma , and IL-6 responses to TT were *enhanced* after 8 and 14 days ( P < .002-.05 ) , while responses increased significantly within 3 days ( P < .04 ) and fell below baseline levels after 14 days ( P < .008 ) . Positive_regulation TNF IL5 21113640 2407579 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL5 2113076 135526 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL5 21871585 2510364 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL5 22870498 2641397 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL5 22995521 2689024 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL5 23702712 2792431 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL5 2404745 128021 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL5 2471522 111736 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL5 3011946 59738 Tumor necrosis [factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL5 3260265 94481 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL5 3486936 60080 Tumor necrosis factor ( [cachectin] ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL5 3526909 62630 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL5 7536712 300186 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL5 8132326 251504 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL5 8333833 223723 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL5 8592105 341949 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL5 8894441 392382 The AD group demonstrated a significantly lower production of [TNF-alpha] and IFN-gamma compared with the two other groups , and IL-4 and production *increased* in the IA group . Positive_regulation TNF IL5 9548401 498868 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL6 10049519 557561 Generation of inflammatory cytokines in zymosan induced pleurisy in rats : [TNF] *induces* and cytokine induced neutrophil chemoattractant ( CINC ) in vivo . Positive_regulation TNF IL6 10068127 594062 MIF-A3 does induce secretion of , but does not *induce* secretion of [TNFalpha] , IL-1beta , and GM-CSF . Positive_regulation TNF IL6 10362713 620137 In contrast , [tumor necrosis factor (TNF)-alpha] ( 200 U/ml ) *induced* at the protein and mRNA levels in both airway epithelial cells and lung fibroblasts . Positive_regulation TNF IL6 10385526 625564 We show that A20 does not inhibit TNF- induced nuclear translocation and DNA binding of NF-kappaB , although it completely prevents the [TNF-] induced *activation* of an NF-kappaB dependent reporter gene , as well as TNF induced and granulocyte macrophage-colony stimulating factor gene expression . Positive_regulation TNF IL6 10391095 626197 In the conditioned medium , marked secretion was *induced* from WI-38 cells by IL-1beta or [TNF-alpha] . Positive_regulation TNF IL6 10569696 568024 Both IL-4 and IL-13 significantly inhibited [TNF] *induced* release ( P < 0.01 for both ) while augmenting the effect of IFNgamma ( P < 0.005 and P < 0.01 , respectively. ) . Positive_regulation TNF IL6 10616907 575884 We report that [TNF] induces DNA replication in growth arrested LE6 cells and that its effect *involves* the activation of NFkappaB and STAT3 and an increase in c-myc and mRNAs . Positive_regulation TNF IL6 10653854 663327 It is well known that [TNF-alpha] *induces* production from synovial cells as well as their proliferation . Positive_regulation TNF IL6 10653854 663330 In addition , the IL-6-sIL-6R complex reduced the TNF-alpha induced proliferation of synovial cells while [TNF-alpha] *induced* their production . Positive_regulation TNF IL6 10781614 714394 Like IL-6 , [TNF-alpha] , which activates both NF-kappaB and p38 , also *induced* p38 dependent expression and release and protected myocytes from apoptotis . Positive_regulation TNF IL6 10821806 694644 In myocardium from control animals , neither [TNF-alpha] nor IL-1beta were *detected* , whereas was present at very low levels . Positive_regulation TNF IL6 10878380 708971 The acute-phase response ( APR ) is regulated by [TNF-alpha] , IL-1beta , and *acting* alone , in combination , or in concert with hormones . Positive_regulation TNF IL6 10930297 719779 Since PGE2 has an opposite effect on TNF and IL-6 production , inhibiting that of [TNF] but *inducing* that of , we investigated the effect of S-KPF on TNF and IL-6 production in vivo following LPS injection . Positive_regulation TNF IL6 10946312 723055 Reperfusion of the ischemic myocardium is associated with a dramatic inflammatory response leading to [TNF-alpha] release , *induction* , and subsequent neutrophil mediated cytotoxic injury . Positive_regulation TNF IL6 11104733 756509 Reverse transcriptase/polymerase chain reaction and ribonuclease protection assays suggested that these opposite effects of increased [ cAMP ] ( i ) on [TNF-alpha-] *induced* and RANTES secretion may occur at the transcriptional level . Positive_regulation TNF IL6 11354283 815309 Following the addition of lipopolysaccharide to control cells , [tumor necrosis factor-alpha] , interleukin-1alpha and mRNA levels *increased* . Positive_regulation TNF IL6 11414308 828929 After hepatectomy , a significant rise in serum [tumor necrosis factor-alpha (TNF-alpha)] was observed at 1 hr , the levels had *increased* at 3 hr , and PGE2 levels had increased at 6 hr , but there were no significant increases in endotoxin levels in portal vein blood . Positive_regulation TNF IL6 11554784 859925 [TNF-alpha] *induced* the release of IL-8 ( P < 0.01 ) and ( P < 0.05 ) from the duodenal explants . Positive_regulation TNF IL6 11576469 865152 Hypoxic upregulation of [TNF] receptor type 2 expression *involves* and is independent of HIF-1 or HIF-2 . Positive_regulation TNF IL6 11696251 894914 increased at 7 weeks and [TNFalpha] *increased* in unstimulated cultures at 3 and 7 weeks but decreased at these times in LPS and SAC stimulated cultures . Positive_regulation TNF IL6 11853880 913402 Previous studies from our laboratory have shown that [TNF] *induces* mRNA expression in cultured skeletal muscle cells . Positive_regulation TNF IL6 11919083 926009 We found that [TNF-alpha] *induced* gene expression in ASM cells via a nuclear factor (NF)-kappaB dependent pathway , whereas RANTES gene expression was mediated via activation of activator protein (AP)-1 and nuclear factor of activated T cells ( NF-AT ) . Positive_regulation TNF IL6 11943316 928690 The objectives of this study were to determine interleukin (IL)-1 beta , IL-2 , IL-4 , IL-5 , , IL-8 , IL-10 , interferon (IFN)-gamma and [tumor necrosis factor (TNF)-alpha] *induction* in bronchoalveolar lavage (BAL) of control horses and horses with heaves both during remission and exacerbation of the disease , and to determine the effect of therapy with inhaled fluticasone propionate on the cytokine profile of horses with heaves . Positive_regulation TNF IL6 12184542 978130 This study assessed a role for , IL-8 , and [TNF-a] in H. pylori *induced* endothelial cytostasis . Positive_regulation TNF IL6 12188027 979947 [TNF-alpha] mRNA induction was maximum within 3 h , IL-6 mRNA was gradually induced up to 24 h , and IL-1beta and IL-12 mRNA were highly induced at 24 h . IL-1beta and protein levels also *increased* within 24 h in a dose dependent manner and reached a maximum with 100 microg/ml ginsan . Positive_regulation TNF IL6 12475184 1023526 The solution of Abeta ( 5 microM ) formed by 2-h incubation at room temperature *induced* [tumour necrosis factor-alpha (TNF-alpha)] and interleukin (IL)-6 levels by 55 and 45 % , respectively , and increased gelatinase B activity by 67 % , while exposure of cells to the ACT/Abeta1-42 mixture ( 1 : 10 molar ratio ACT : Abeta1-42 ) under the same experimental conditions showed no effect on levels or gelatinase B activity , but strongly induced TNF-alpha ( by 190 % ) , compared to the controls . Positive_regulation TNF IL6 12557750 1029079 The Saa1 and Saa2 promoters are strongly *induced* by , with synergistic upregulation of Saa2 , but not of Saa1 , by IL-1 or [TNF] . Positive_regulation TNF IL6 12626436 1079880 Exercise and infusion inhibit endotoxin *induced* [TNF-alpha] production in humans . Positive_regulation TNF IL6 12668157 1075705 [TNFalpha] and insulin *induced* production from PBC , but had no effect on adipocytes . Positive_regulation TNF IL6 12682447 1077806 [Tumor necrosis factor-alpha] , interleukin-1 , and *increase* tissue factor and inhibit fibrinolysis , thereby activating the extrinsic pathway . Positive_regulation TNF IL6 12889600 1117206 [Tumor necrosis factor-alpha] *induces* production via extracellular regulated kinase 1 activation in breast cancer cells . Positive_regulation TNF IL6 12911858 1122177 The [TNF-alpha] in plasma may partially *induce* transcription of and IL-8 , which contribute to the CD14 independent increase in level of mRNA for IL-6 and IL 8 . Positive_regulation TNF IL6 12913922 1129684 [TNF-a] stimulation *induced* secretion by RA SFB ( 3-fold ) and OA SFB ( 4-fold ) , as well as MMP-1 secretion ( RA , 85-fold ; Positive_regulation TNF IL6 1334048 205814 Both IL-1 and [TNF] *induced* PCA , reduced TM , and induced production in a dose dependent manner . Positive_regulation TNF IL6 1424289 202246 ( iv ) [TNF-alpha] in the *presence* or absence of and/or prednisolone did not induce the production of SAA or CRP by HepG2 cells . Positive_regulation TNF IL6 1431212 202869 In contrast , LPS and [TNF] *induced* prolonged stimulation of production by HDMEC as IL-6 mRNA transcripts were still detected after 24 h treatment and IL-6 protein was markedly increased at this timepoint . Positive_regulation TNF IL6 14607246 1162052 [TNF] *induced* an increase of expression in PC12 cells at 4-6 hr . Positive_regulation TNF IL6 1504836 193903 [TNF alpha] *induces* production by astrocytes but not by microglia . Positive_regulation TNF IL6 15119636 1241963 Appearance of *increased* 17 % and 43 % ( p < 0.01 ) , and [TNFalpha] appearance increased 14 % and 50 % ( p < 0.01 ) when dialysate volumes of 2.5 and 3.0 L were used , compared with 2.0 L . Positive_regulation TNF IL6 15211029 1262151 We observed constitutive expression of , IL-8 , granulocyte macrophage colony stimulating factor ( GM-CSF ) , and monocyte chemoattractant protein (MCP)-1 in both human and baboon endothelial cells , and these cytokines were further *induced* by [TNF-alpha] and LPS . Positive_regulation TNF IL6 15248214 1271194 CD14+ RA synovial cells stimulated with rsCD154 plus interferon-gamma (IFNgamma) *induced* significantly higher production of , IL-8 , and monocyte chemoattractant protein 1 by FLS compared with unstimulated CD14+ synovial cells , through [TNFalpha-] , IL-1alpha- , and IL-1beta mediated pathways . Positive_regulation TNF IL6 1527383 197552 Finally , IL-1 beta plus [TNF-alpha] *induced* the production of , but not of Ig , by adherent BM cells . Positive_regulation TNF IL6 1527383 197556 These results suggest that IL-1 beta and [TNF-alpha] produced by adherent BM cells synergistically *induce* early generation , which , in turn , drives BM B cell producers into the high rate Ig-secreting state . Positive_regulation TNF IL6 15316669 1286287 IL-1 , but not [TNF-alpha] , can *induce* , bone morphogenic protein 2 (BMP-2) , and cyclooxygenase ( COX-2 ) expression in SW1353 cells . Positive_regulation TNF IL6 15328477 1296873 Accordingly , [TNF-alpha] , which did not *induce* release , also did not induce gliosis . Positive_regulation TNF IL6 15474068 1318823 [Tumor necrosis factor-alpha] *induced* the release of from endometriotic stromal cells by the nuclear factor-kappaB and mitogen activated protein kinase pathways . Positive_regulation TNF IL6 1548355 183788 Interleukin 1 ( alpha and beta ) and [tumor necrosis factor (TNF)] all *induced* a significant concentration dependent stimulation of production by decidual cells . Positive_regulation TNF IL6 15517620 1328655 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL6 15642135 1363109 [TNF-alpha] *induced* and OPG production by synoviocytes , which was further increased with patient plasma dilutions and inhibited by infliximab . Positive_regulation TNF IL6 15655672 1375888 VSMCs were exposed to 44 degrees C for 15-60 min , and subjected to interleukin-1beta (IL-1beta) or [tumor necrosis factor alpha (TNFalpha)] , which *induced* production . Positive_regulation TNF IL6 15683451 1370619 The lymph node homing chemokine receptor CCR-7 expression was induced by TNF-alpha + IL-1beta + + prostaglandin E2 but was not *induced* by Poly I:C + [TNF-alpha] . Positive_regulation TNF IL6 15693092 1371524 [TNF-a] *induced* increases in , IL-8 , and COX-2 mRNA were suppressed by dexamethasone in both fd-FLS and td-FLS . Positive_regulation TNF IL6 15731288 1439205 [TNFalpha] and IL1beta *induced* production by normal muscle samples and myoblasts , the action of TNFalpha being more potent on muscle samples . Positive_regulation TNF IL6 15804596 1390934 A. actinomycetemcomitans clearly *induced* , IL-1beta , and to a minimal extent , [tumor necrosis factor (TNF)-alpha] mRNA expression . Positive_regulation TNF IL6 1582974 187613 IFN-alpha and [TNF] *induce* an autocrine production of in myeloma-cell lines and make possible the autonomous growth of these cell lines . Positive_regulation TNF IL6 1598496 188841 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL6 16000387 1447304 In the present study , incubation of AM with unopsonized Pneumocystis organisms was not associated with release of interleukin (IL)-1beta , , or tumor necrosis factor (TNF)-alpha ( important cytokines in the host response to Pneumocystis ) and did not *induce* IL-1beta , IL-6 , or [TNF-alpha] mRNA transcripts . Positive_regulation TNF IL6 1611281 191046 CK-M stimulated thioglycollate *induced* peritoneal macrophages to produce interleukin 1 (IL-1) and [tumor necrosis factor alpha (TNF-alpha)] at concentrations of 1-100 ng/ml , and it also induced IL-2 and interferon-gamma (IFN-gamma) as well as production by splenocytes . Positive_regulation TNF IL6 16175346 1461820 [TNF-alpha] and IL-1beta are early regulators of the immune response and both *induce* the release of secondary cytokines , such as and IL-8 . Positive_regulation TNF IL6 16221503 1517851 In the presence of serum , [tumor necrosis factor-alpha] , lipopolysaccharide and *increased* HAMP expression in hepatocytes from both control and iron loaded rats . Positive_regulation TNF IL6 1629700 191886 In addition , based on a thymidine incorporation assay , [TNF-alpha] inhibited , but strongly *increased* , the DNA synthesis in SK-N-MC cells , whereas in the SH-SY5Y cell line no such differences were seen . Positive_regulation TNF IL6 16343598 1519254 Our results indicate that the serum from aged rats significantly impairs the capacity of young macrophages to *induce* [tumor necrosis factor-alpha (TNF-alpha)] production , while at the same time it increases the basal levels of . Positive_regulation TNF IL6 16413378 1513954 [TNF-alpha] and IL-1beta ( 0.01 to 100 ng/mL ) *induced* secretion of IL-8 , , and RANTES in a dose and time dependent manner . Positive_regulation TNF IL6 1657127 168898 Nevertheless , GalN had no influence on [TNF] clearance or *induction* after mTNF injection ; Positive_regulation TNF IL6 16586095 1574801 In contrast , [TNF-alpha] *induced* rapid and substantial increases in expression of the genes encoding , MCP-1 , NGF and TNF-alpha itself ; Positive_regulation TNF IL6 1667942 176670 Both IL-1 and [TNF-alpha] *induced* production by synovial fibroblasts in a dose dependent manner . Positive_regulation TNF IL6 16752297 1566689 At a concentration of 88 particles/cell , bone cement particles yielded a 2-fold increase ( 327 pg/mL ) in soluble receptor activator for nuclear factor kappa B ligand secretion , a 5-fold ( 239 pg/mL ) increase in secretion and 4-fold ( 129 pg/mL ) *increase* in [tumor necrosis factor-alpha] secretion . Positive_regulation TNF IL6 16765637 1585508 Statistically significant differences between the groups were obtained for TNF-alpha and IL-6 : [TNF-alpha] was *detected* in 3 cases in group A , and in none of the other groups , while was elevated in 10/16 patients in group A , 4/9 in group B , and 4/26 in group C. sTNF-R was not significantly different for the three groups . Positive_regulation TNF IL6 17005253 1666311 In contrast , both IL-1beta and [TNFalpha] highly *induced* secretion in chorion derived cells , demonstrating the overall responsiveness of these cells to these stimuli . Positive_regulation TNF IL6 17014668 1629393 levels peaked on POD 1 decreasing to POD 7 , and [TNF-alpha] levels *increased* from PODs 1 to 7 . Positive_regulation TNF IL6 1710458 158187 Inhibition of [TNF alpha] biosynthesis and *induction* of acute phase protein formation by are discussed as possible factors in the development of endotoxin tolerance . Positive_regulation TNF IL6 17204394 1747172 gp120 induces the release of interleukin-6 (IL-6) , in addition to IL-1 and TNF , the present study tested whether this release in spinal cord *contributes* to gp120 induced mechanical allodynia and/or to gp120 induced increases in [TNF] and IL-1 . Positive_regulation TNF IL6 1727819 180933 These results suggest that trophoblast derived [TNF alpha] *induced* release and then activated the IL-6-R system in trophoblasts to release hCG . Positive_regulation TNF IL6 17297444 1765616 In vitro , SOCS3 overexpression reduced proliferation , mediated STAT3 *activation* and [tumor necrosis factor (TNF)] alpha mediated NF-kappaB activation . Positive_regulation TNF IL6 17320860 1711782 As a result , the produced by RAW264.7 cells is an *inducer* of [TNFalpha] expression in 3T3-L1 adipocytes , and the IL-6 secretion is inhibited by the activation of PPARalpha . Positive_regulation TNF IL6 17413040 1742226 Inhibitors of JAK , p38 , and NF-kappaB revealed that these signaling pathways are indispensable for the plasmin mediated [tumor necrosis factor-alpha] and *induction* . Positive_regulation TNF IL6 17513458 1772843 Recombinant [TNF-alpha] *induced* production by lung monocytic cells exposed to intra-amniotic endotoxin but not in control cells . Positive_regulation TNF IL6 17577102 1763604 The inhibitors of JNK , NF-kappaB , and STAT-3 produced a statistically significant decrease of the [TNF-alpha] *induced* U937 adhesion and protein release . Positive_regulation TNF IL6 17641010 1771212 The mature DC ( CD83 ( + ) CD70 ( + ) HLA-DR ( high ) CD14 ( low ) ) expressed high levels of mRNA for , IL-15 , and IL-23 , *induced* naive CD4 T cells to produce IFN-gamma and [TNF-alpha] , and stimulated resting CD4 T cells to secret IL-17 . Positive_regulation TNF IL6 17692882 1816683 Wild-type PIV5 infection *induces* little , if any , expression of cytokines such as IL-6 or [TNF-alpha] , whereas infection by a mutant PIV5 lacking the conserved C-terminal cysteine rich domain ( rPIV5VDeltaC ) induced high levels of expression . Positive_regulation TNF IL6 17959968 1814999 [Tumor necrosis factor-alpha] and levels *increased* less in the propofol groups than in the thiopental groups . Positive_regulation TNF IL6 1796655 176326 It will focus on interleukin-1 (IL-1) , IL-1 inhibitors , [Tumor-Necrosis-Factor-alpha (TNF-alpha)] , TNF *inhibitors* , , colony stimulating factors (CSF's) , Interferon-gamma (IFN-gamma) , growth factors , eicosanoids and prostaglandins , all of which are important in the effector phase of tissue destruction . Positive_regulation TNF IL6 17967442 1826506 Only IL-1alpha , but not [TNFalpha] , *induced* in the IL-1alpha/beta/TNFalpha KO mouse brain , while both cytokines induced cyclooxygenase (Cox)-2 . Positive_regulation TNF IL6 18029463 1860724 Plasma [TNF-alpha] levels increased from 0.7 +/- 0.04 to 16.7 +/- 1.8 pg/ml , and plasma *increased* from 1.0 +/- 0.2 to 9.2 +/- 1.0 pg/ml ( P < 0.05 ) after 4-h rhTNF-alpha infusion . Positive_regulation TNF IL6 18195163 1863345 [Tumor necrosis factor-alpha] *induced* complement C3 and expression in VSMCs . Positive_regulation TNF IL6 18214991 1895511 We show that CNTF reduces COX-2 levels , whereas *increases* the expression of IL-1beta , [TNFalpha] , and Cox-2 . Positive_regulation TNF IL6 18258304 1884768 Here we report that [TNF] *induced* pro-inflammatory cytokine synthesis of and IL-8 is mediated by the Rho GTPase Rac . Positive_regulation TNF IL6 18313744 1879829 Experiments employing neutralising antibodies indicate that exposure of co-cultured macrophages to both Ti-based particles *induces* the release of M-CSF , GM-CSF , and PGE2 through up-regulation of IL-1beta and [TNF-alpha] . Positive_regulation TNF IL6 18492334 1917106 Our study demonstrated that after stimulation of alveolar macrophages by Mce4E protein for 48 h , the expression of [TNF-alpha] was *induced* , with an enhanced mRNA level ( P < 0.05 ) and no changes in IL-12 expression in the macrophages . Positive_regulation TNF IL6 1849793 155473 [TNF] *induced* the secretion of in these cells , additionally showing that functional TNF signaling in these cells indeed takes place , but does not lead to cell lysis under normal conditions . Positive_regulation TNF IL6 18552402 1945960 Expression of and leukemia inhibitory factor (LIF) was *induced* by [TNFalpha] in wild-type and JNK2-null myoblasts . Positive_regulation TNF IL6 18611594 290012 IL-1alpha and [TNFalpha] *induce* the secretion of and IL-8 and the upregulation of mRNAs for IL-1alpha , IL-1beta , IL-6 and IL-8 . Positive_regulation TNF IL6 1863822 164002 [TNF alpha] induced no detectable amounts of IL-1 ( less than 0.01 U ) in young or old cartilage but did *induce* production . Positive_regulation TNF IL6 1873476 165281 IL-1 alpha and [tumor necrosis factor] markedly *induced* steady state levels of at 20 h in serum-free conditions , whereas transforming growth factor-beta ( TGF-beta ) , epidermal growth factor , and 10 % fetal calf serum did not . Positive_regulation TNF IL6 18755151 1975281 In addition , we found that IFNgamma and [TNF] also increased IL-6 expression by BMSCs , and further *increased* the killing of tumor cells by BMSCs . Positive_regulation TNF IL6 18786965 1976022 On the other hand , [TNF-alpha] and IL-17 did not *induce* RANKL expression , although TNF-alpha , IL-17 or IL-1beta stimulated cell growth and production . Positive_regulation TNF IL6 18792875 1963746 [TNF-alpha] *induces* production of and it has been suggested that a causal relationship exists between endothelial dysfunction and these cytokines . Positive_regulation TNF IL6 19012188 1991682 [Tumor necrosis factor-alpha] , interleukin (IL)- 1beta , and *increased* significantly in both groups . Positive_regulation TNF IL6 19514423 2092701 Patients with highly active hepatitis and maximal morphological changes in the liver had significant lowering of NDV induced production of IFN-alpha , IFN-gamma , TNF-alpha , and PGA *induced* production of [TNF-alpha] . Positive_regulation TNF IL6 19671412 2119500 [TNF-alpha] ( 1 microg/L ) strongly *induced* the production of and IL-8 as compared with the control serum in A549 cells , and the induced cytokine production was significantly suppressed by 15 % serum containing Feiyanning Decoction ( P < 0.01 ) . Positive_regulation TNF IL6 19686583 2138958 IL-17 and [TNF-alpha] synergistically *induced* granulocyte chemotactic protein-2 ( GCP-2 ) , and receptor activator of NFkappaB ligand ( RANKL ) in MEF . Positive_regulation TNF IL6 19747158 2163334 Expression of [TNF-alpha] was *detected* at 8 months of age , while IL-1 beta , and MCP-1 at 10 months . Positive_regulation TNF IL6 20053934 2225387 [TNFalpha] stimulation *induced* production of inflammatory cytokines such as and IL-8 in RSF , and the extent of IL-6 and IL-8 induction was dramatically reduced by CHPD under noncytotoxic concentrations . Positive_regulation TNF IL6 2012180 156667 Interleukin-1 beta and [tumor necrosis factor-alpha] *induce* gene expression and production of leukocyte chemotactic factors , colony stimulating factors , and in human mesangial cells . Positive_regulation TNF IL6 20205746 2229765 These results strongly suggest that [TNF-alpha] *induces* synthesis through the JAK/STAT3 pathway in addition to p38 MAP kinase and SAPK/JNK in C6 glioma cells , and that phosphorylation of NFkappaB at Ser 536 and Ser 468 , and NADPH oxidase are involved in TNF-alpha stimulated IL-6 synthesis . Positive_regulation TNF IL6 2027138 157483 production was *induced* by IL-1 alpha and [TNF-alpha] . Positive_regulation TNF IL6 20589530 2296351 Engagement of SIGNR1 on PEMs with an anti-SIGNR1-specific rat IgM antibody , ERTR9 , *induced* production of IL-12 and [tumor necrosis factor (TNF)-alpha] from PEMs , while secretion of and IL-1beta was not detected with the same treatment . Positive_regulation TNF IL6 20665032 2531489 Nicotine inhibits [tumor necrosis factor-a] *induced* and IL-8 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis . Positive_regulation TNF IL6 21113640 2407580 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL6 2113076 135527 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL6 21136335 2355903 We determined the effect of DMF on platelet derived growth factor (PDGF)-BB induced proliferation , as well as on PDGF-BB and [tumor necrosis factor (TNF)-a] *induced* secretion and on activation of activated protein (AP)-1 and nuclear factor kappaB ( NF-?B ) . Positive_regulation TNF IL6 21136335 2355907 PDGF-BB and [TNF-a] *induced* secretion by lung fibroblasts and this was inhibited by DMF in a dose dependent manner . Positive_regulation TNF IL6 21190512 2396793 may also *mediate* [TNF-a] effects on acute phase protein gene expression . Positive_regulation TNF IL6 21191629 2425302 [Tumor necrosis factor-a] *induces* expression and release of by human urothelial cells . Positive_regulation TNF IL6 21229279 2419645 Plasma levels of [tumor necrosis factor-a (TNF-a)] , interleukin 8 (IL-8) , interferon-? inducible protein-10 (IP-10) , monocyte chemotactic protein-1 (MCP-1) , soluble urokinase-type plasminogen activator ( suPAR ) , monokine *induced* by ?-interferon ( MIG ) , human hepatocyte growth factor (HGF) , insulin , , interleukin 1-ß (IL-1ß) , leptin , and nerve growth factor (NGF) were analyzed . Positive_regulation TNF IL6 21273803 2360662 [TNF-a] , IL-1 and expression *increased* early in the lungs and pancreas , with a partial recovery by the end of the study . Positive_regulation TNF IL6 21300032 2403521 Combined ß-adrenergic and [TNF-receptor] triggering *induces* synergistic expression in 1321N1 cells via a transcriptional enhancer mechanism . Positive_regulation TNF IL6 21378563 2416020 In a septic chimeric murine model , wild-type mice had decreased cardiac function and *increased* myocardial [TNF-a] and levels whereas TLR-4 knockout mice had attenuated responses to lipopolysaccharide challenge ; Positive_regulation TNF IL6 21722069 2515910 IFN-? and [TNF-a] *induce* a different modulation of in systemic sclerosis fibroblasts compared to healthy controls . Positive_regulation TNF IL6 21806874 2462489 [TNF] *induced* release from P815 cells may involve activation of ERK signalling pathway . Positive_regulation TNF IL6 21871585 2510365 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL6 21994466 2516421 [TNF receptor (TNFR)] 2 expression is *increased* in inflammatory bowel diseases , the azoxymethane/dextran sodium sulfate ( AOM/DSS ) model of colitis associated cancer , and by combined and TNFa . Positive_regulation TNF IL6 2203522 140651 while could be *induced* by both IL-1 beta and [tumor necrosis factor-alpha] . Positive_regulation TNF IL6 22056354 2527959 Gene expression ( mRNA ) of MCP-1 , IL-1ß , IL-6 and [TNF-a] was *increased* in sections 2 and 3 starting at week 12 ( P < 0.05 ) , with further increases in MCP-1 , IL-1ß and at 16 weeks ( P < 0.05 ) . Positive_regulation TNF IL6 22190977 2531317 [TNF-a] stimulation also *induced* secretion in OA FLSs ; Positive_regulation TNF IL6 22637477 2625551 With cultured vascular smooth muscle cell , angiotensin II , arachidonic acid , and [TNF-a] markedly *induce* increased expression of and TNF-a mRNAs , all of which were suppressed by inhibiting iPLA(2)ß activity or expression with bromoenol lactone , antisense oligonucleotides , and genetic deletion , respectively . Positive_regulation TNF IL6 22870498 2641398 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL6 2290028 149505 The secretion of could also be *induced* by interleukin (IL)-1 beta and [tumor necrosis factor] ( TNF-alpha ) . Positive_regulation TNF IL6 2294996 127513 did not *stimulate* IL-1 beta or [TNF] production , but suppressed IL-1 beta and TNF production induced by LPS or PHA by 30 % ( P less than .01 ) . Positive_regulation TNF IL6 22995521 2689025 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL6 23029958 2681073 Plasma IL-6 and [TNF-alpha] *increase* with acute moderate exercise and increases further with acute strenuous exercise . Positive_regulation TNF IL6 23046548 2706511 Unopsonized IE *induced* secretion of IL-6 ( median= 622 pg/ml [ IQR=1,250-240 ] , n=9 ) but no IL-1ß or [TNF] , whereas PPS opsonized IE induced secretion of IL-1ß ( 18.6 pg/mL [ 34.2-14.4 ] ) and TNF ( 113 pg/ml [ 421-17.0 ] ) and increased secretion ( 2,195 pg/ml [ 4,658-1,095 ] ) . Positive_regulation TNF IL6 23512893 2843503 FFAs *increased* the expression of tumor necrosis factor ( [TNF] ) a , , and monocyte chemotactic protein (MCP)-1 in SC and omental preadipocytes . Positive_regulation TNF IL6 23702712 2792432 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL6 23712050 2838437 Remnant livers of Ldlr ( - ) ( / ) ( - ) showed a time shifted expression of and a defective *activation* of [tumor necrosis factor-a (TNFa)] and hepatocyte growth factor (HGF) expression in early phases of liver regeneration . Positive_regulation TNF IL6 23718062 2793138 [TNF-a] , and C-reactive peptide levels *increased* by 3 , 2 and 2.5-4 times in groups 2 and 3 . Positive_regulation TNF IL6 2374440 138430 Recombinant did not have the activity but it could significantly *increase* the activity of recombinant [TNF] . Positive_regulation TNF IL6 23810685 2834475 THC *inhibited* the production of [TNF-a] and IL-6 by down regulating LPS induced and TNF-a mRNA expression . Positive_regulation TNF IL6 23862224 2817453 [TNF-alpha] + CAPE *induced* statistically lower expressions of and p-STAT3 than TNF-alpha alone ( P < 0.05 ) . Positive_regulation TNF IL6 2404745 128022 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL6 24290899 2904685 Elevated levels and neutrophil counts also reduced the risk of abnormal FEV1 but in contrast to CRS , increased [TNF-a] did not *increase* the risk of abnormal FEV1 . Positive_regulation TNF IL6 2471522 111737 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL6 25066751 2953737 While significant alterations were observed in all cytokines during the monitoring period , levels remained consistently higher in fatal cases and [TNF-a] levels *increased* in both in fatal and non-fatal CCHF cases . Positive_regulation TNF IL6 2523936 109925 IL-1 and [TNF] *induced* concentration related increases in the synthesis of factor B , C3 , and IFN-beta <2/IL-6> in human skin fibroblasts . Positive_regulation TNF IL6 2805453 121191 Endotoxin , [tumor necrosis factor-alpha] and interleukin 1 *induce* production in vivo . Positive_regulation TNF IL6 2805453 121245 The ability of Escherichia coli derived lipopolysaccharide (LPS) , recombinant ( r ) interleukin 1-beta ( rIL-1 beta ) , and r murine [tumor necrosis factor-alpha] ( rMuTNF-alpha ) to *induce* production in vivo was investigated . Positive_regulation TNF IL6 3011946 59739 [Tumor necrosis factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL6 3260265 94482 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL6 3486936 60081 [Tumor necrosis factor] ( cachectin ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL6 3526909 62631 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL6 7536422 297247 could also be *induced* by [TNF-alpha] added to brain cultures . Positive_regulation TNF IL6 7536712 300187 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL6 7538467 301320 The difference in the signaling was further evident from our observation that [TNF] *induced* the expression of but anti-Fas did not . Positive_regulation TNF IL6 7640348 317850 In addition , [TNF] *induced* production was also enhanced . Positive_regulation TNF IL6 7683736 216561 IL-3 , , interferon gamma , GCSF and to a smaller extent IL-1 beta and GMCSF synergized the differentiation *inducing* activity of [TNF] . Positive_regulation TNF IL6 7691110 228736 Both IL-1 and [TNF alpha] *induced* a dose dependent release of ( 5 to 10 ng/10 ( 6 ) cells ) and GM-CSF ( 2 to 3 ng/10 ( 6 ) cells ) by primary epithelial cells from eight normal volunteers . Positive_regulation TNF IL6 7868900 296527 Moreover , [IFN-gamma/TNF] production was negatively *regulated* by . Positive_regulation TNF IL6 7927780 273971 Collectively , our data are compatible with the hypothesis that is *involved* in negative feedback regulation of plasma [TNF-alpha] levels in experimental GBS sepsis . Positive_regulation TNF IL6 7929820 274667 We present data to show that the expression of [TNF alpha] is *regulated* by the transcription factor C/EBP beta ( ) . Positive_regulation TNF IL6 7962300 279367 Plasma IL-1 beta and tumor necrosis factor-alpha concentrations , assayed by specific enzyme linked immunosorbent assays during the 4 h after the first IL-6 injection , were either within the normal range or undetectable , confirming in vitro observations that does not *stimulate* IL-1 beta or [tumor necrosis factor-alpha] secretion and suggesting that it exerts its effect on the HPA axis and AVP secretion independently of them . Positive_regulation TNF IL6 7970084 280013 No significant production by PTEC could be *induced* by [TNF alpha] , IL-2 , IFN gamma , or LPS over a broad dosage range . Positive_regulation TNF IL6 8108469 246179 Both IL-1 and [TNF] can *induce* the synthesis of by a variety of cells . Positive_regulation TNF IL6 8132326 251505 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL6 8164509 254580 Furthermore , supernatant levels were decreased , but [tumor necrosis factor] ( TNF-alpha ) levels were *increased* by THC treatment . Positive_regulation TNF IL6 8284058 240643 The purpose of this study was to determine if endotoxin , [tumor necrosis factor (TNF)] , and *increased* in patients during or after total hip arthroplasty . Positive_regulation TNF IL6 8328832 223502 IL6 and [TNF alpha] levels were *increased* in severely infected patients as compared to patients who remained free of infection , and the level was higher in infected patients who died than those who survived . Positive_regulation TNF IL6 8333833 223724 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL6 8346413 226972 , as previously reported , acts at late stages of low-dose IL-2 culture to enhance LAK , but does not *stimulate* [TNF-alpha] production . Positive_regulation TNF IL6 8406825 233067 Whereas had no effect , IL-1 alpha or [TNF] *induced* partial tolerance to LPS in terms of inhibition of LPS stimulated TNF and IL-6 production . Positive_regulation TNF IL6 8409382 233331 3 ) [TNF] *induces* direct thymocyte apoptosis ( a property not shared by IL-1 beta , IL-2 , IL-4 , and IL-7 ) . Positive_regulation TNF IL6 8429684 212727 Purified T-cells did not produce significant levels of [TNF-alpha] , even in the *presence* of IL-1 and . Positive_regulation TNF IL6 8495426 219511 In the L929 fibrosarcoma cell line , staurosporine also enhanced the transcriptional *activation* of synthesis by [TNF] ( 500-fold stimulation at 56 nM ) . Positive_regulation TNF IL6 8510131 221709 M1Av stimulated thioglycolate *induced* peritoneal macrophages from C3H/HeN and C3H/HeJ mice to release cell-free [tumour necrosis factor (TNF)] and , and a cell associated thymocyte activating factor , probably IL-1 . Positive_regulation TNF IL6 8537402 338617 Transcriptional *roles* of nuclear factor kappa B and nuclear in the [tumor necrosis factor] alpha dependent induction of cyclooxygenase-2 in MC3T3-E1 cells . Positive_regulation TNF IL6 8589269 342384 There was an early increase in , soluble receptors of TNF , and in IL-1 receptor antagonist in both groups , but no detectable *increase* in plasma IL-1 or [TNF] . Positive_regulation TNF IL6 8589669 341856 Five high molecular weight glycolipids capable of stimulating human peripheral whole-blood cell cultures to cause and [tumor necrosis factor (TNF)-alpha] *induction* were isolated from one of the lipoteichoic acid fractions ( LTA-2 ) extracted from Enterococcus hirae ATCC 9790 ( Tsutsui et al. , ( 1991 ) FEMS Microbiol . Positive_regulation TNF IL6 8592105 341950 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL6 8624246 360186 In the same cultures , [tumor necrosis factor-alpha] *induced* marked increases in release of both IL-8 and at 24 and 48 h after stimulation . Positive_regulation TNF IL6 8665189 368696 [TNF] was *detected* in only 17 patients on the first day of admission , while soluble TNF receptors were detected in all patients and in 34 . Positive_regulation TNF IL6 8724991 373817 Given that IL-1 and [TNF alpha] , monokines derived from microglia , *induce* production in astrocytes , but not in microglia , results indicate that astrocytes and microglia may mutually regulate IL-6 production by different cytokines . Positive_regulation TNF IL6 8743284 377147 This study provides no arguments for the involvement of endogenous IL-1 in [TNF alpha-] or induced *activation* of the HPA axis . Positive_regulation TNF IL6 8894441 392375 The combination ION + PMA *induced* the highest levels of IL-2 , IL-4 , IL-5 , IFN-gamma and [TNF-alpha] , whereas maximal production of and TNF-beta were induced by PHA and PHA + PMA , respectively . Positive_regulation TNF IL6 9050747 406033 That *increased* the binding of [TNF-alpha] on the surface of the hepatic cells , whereas TNF-alpha alone downregulated its own specific binding capacity is reported . Positive_regulation TNF IL6 9058758 417684 In particular , [TNFalpha] promotes oligodendrocyte and myelin pathology , and expression is *induced* in astrocyte and microglial cultures that have been incubated with TNFalpha or myelin debris , respectively . Positive_regulation TNF IL6 9087647 421676 The data indicate that IL-1 and [TNF] *act* locally at the site of inflammation and that locally induced is the important systemic mediator of the response . Positive_regulation TNF IL6 9223622 442921 ( 1 ) Dex decreased the accumulation of [tumor necrosis factor-alpha] *induced* by , whereas nitric oxide production was enhanced by Dex . Positive_regulation TNF IL6 9469441 485883 The vasoactive peptide maxadilan from sand fly saliva inhibits [TNF-alpha] and *induces* by mouse macrophages through interaction with the pituitary adenylate cyclase activating polypeptide ( PACAP ) receptor . Positive_regulation TNF IL6 9481405 487703 [Tumor necrosis factor-alpha (TNF-alpha)] and *increase* the synthesis of hepatic acute-phase proteins ; Positive_regulation TNF IL6 9514300 492162 Decreased IL-1alpha and [TNF-alpha] production in 24-hr culture supernatants of mononuclear cells isolated from liver perfusate was *detected* while remained unchanged over 20 weeks . Positive_regulation TNF IL6 9548401 498869 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL6 9558730 500200 that [TNF] *induced* IL1 and production relate in a positive curvilinear fashion to linoleic acid intake ; Positive_regulation TNF IL6 9607578 508529 Suppression of IL-2 mediated [tumor necrosis factor] alpha and *induction* in vivo during the first 24 h after IL-2 administration was observed , and the neutrophil chemotactic defect normally seen with IL-2 was not observed . Positive_regulation TNF IL6 9649471 516467 After 24 hours of EtOH exposure , the release of IL-1 alpha doubled , that of increased 10 times , and that of [TNF-alpha] *increased* 3.5 times . Positive_regulation TNF IL6 9718198 528150 [TNF-alpha] *increases* expression of and ICAM-1 genes through activation of NF-kappaB in osteoblast-like ROS17/2.8 cells . Positive_regulation TNF IL6 9777287 540243 The other proinflammatory cytokines IL-1 beta , and [TNF alpha] remained unchanged , and the increased serum did not *induce* production of c-reactive protein . Positive_regulation TNF IL6 9792466 542539 We observed that ( 1 ) IL-1beta and [TNFalpha] *induced* in a dose and time dependent fashion , ( 2 ) TGFbeta 1 and 2 enhanced basal and IL-1beta and TNFalpha induced IL-6 expression , ( 3 ) ET-1 elicited a dose dependent stimulatory effect on IL-6 expression . Positive_regulation TNF IL6ST 17675290 1794075 By electrophoretic mobility shift assay analyses , [TNF-alpha] and lipopolysaccharide *induce* strong p65/p50 and p65/c-Rel binding to both NF-kappaB and TF-kappaB probes . Positive_regulation TNF IL7 11067918 747439 Our studies showed that [TNF] regulates mouse thymocyte production , inducing both apoptosis and proliferation of the most immature CD3 ( - ) CD4 ( - ) CD8 ( - ) triple negative ( TN ) subset within a broad range of dosages ( 10 ( 1 ) -10 ( 5 ) pg/ml ) in the *presence* of . Positive_regulation TNF IL7 12525379 1048037 stimulated TNFalpha production by SFMC and very potently *stimulated* IFN gamma and [TNF alpha] production by SF CD4+ T cells . Positive_regulation TNF IL7 15517620 1328656 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL7 1598496 188842 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL7 17038478 1630994 *induces* [tumour necrosis factor alpha (TNFalpha)] secretion by T cells and by monocytes after T cell dependent monocyte/macrophage activation . Positive_regulation TNF IL7 17045026 1635679 also *increased* the production of IFN-gamma and [TNF-alpha] in the healthy controls [ ( 211 +/- 57 ) ng/L to ( 292 +/- 92 ) ng/L , ( 1,203 +/- 390 ) ng/L to ( 1,722 +/- 503 ) ng/L , respectively ] , and decreased the production of IL-4 and IL-10 [ ( 43 +/- 13 ) ng/L to ( 36 +/- 11 ) ng/L , ( 135 +/- 37 ) ng/L to ( 96 +/- 36 ) ng/L , respectively ] . Positive_regulation TNF IL7 1717551 166823 Low levels of [TNF] were produced in *response* to at day 5 , as opposed to a 50-fold higher TNF production in response to IL-2 . Positive_regulation TNF IL7 17185327 1724571 To identify the mechanism of *stimulated* [tumour necrosis factor alpha (TNFalpha)] production and to determine the relationship between intra-articular IL7 and TNFalpha expression levels in patients with rheumatoid arthritis ( RA ) . Positive_regulation TNF IL7 17185327 1724573 *induced* cell contact dependent [TNFalpha] production by cocultures of T cells and monocytes , but not by T cells and monocytes cultured separately . Positive_regulation TNF IL7 17185327 1724574 The present data suggest that is an important *inducer* of T cell dependent [TNFalpha] production in RA joints . Positive_regulation TNF IL7 2007858 154853 In addition to promoting IL-6 production , *induced* the secretion of immunoreactive IL-1 alpha , IL-1 beta , and [tumor necrosis factor alpha (TNF-alpha)] by monocytes . Positive_regulation TNF IL7 21113640 2407581 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL7 2113076 135528 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL7 21871585 2510366 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL7 22870498 2641399 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL7 22995521 2689026 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL7 23702712 2792433 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL7 2404745 128023 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL7 2471522 111738 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL7 3011946 59740 Tumor necrosis [factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL7 3260265 94483 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL7 3486936 60082 Tumor necrosis factor ( [cachectin] ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL7 3526909 62632 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL7 7536712 300188 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL7 8132326 251506 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL7 8333833 223725 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL7 8409382 233332 3 ) [TNF] *induces* direct thymocyte apoptosis ( a property not shared by IL-1 beta , IL-2 , IL-4 , IL-6 and ) . Positive_regulation TNF IL7 8592105 341951 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL7 9548401 498870 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL7 9659158 517171 Conversely , antibody to [TNF-alpha] reduced IEL proliferation in *response* to IL-2 or . Positive_regulation TNF IL8 10372996 622133 IL-1beta and [TNF-alpha] *induced* dose dependent increases in HRPE and MCP-1 secretion with maximal stimulation observed at 2-5 ng/ml . IL-4 alone ( 100 ng/ml ) resulted in a slight increase of MCP-1 and IL-8 secretion . Positive_regulation TNF IL8 10417153 631475 gene transcription in L5F11 cells could also be *induced* by the cytokine [tumor necrosis factor alpha (TNF-alpha)] without exposure to H. pylori . Positive_regulation TNF IL8 10425270 632805 In contrast , the pro-inflammatory cytokine [TNFalpha] , whose activity is dependent on the generation of intracellular ROS , *induces* and ICAM-1 in both cell types . Positive_regulation TNF IL8 10690897 670461 [TNFalpha] *induced* the gene and protein expression of in endometriotic stromal cells in a dose dependent fashion . Positive_regulation TNF IL8 10707928 673447 IL-1beta and [tumor necrosis factor (TNF)-alpha] both *induced* a marked increase in C3 and secretion . Positive_regulation TNF IL8 10809292 692524 [TNF-alpha] stimulation *induced* a large increase in . Positive_regulation TNF IL8 10809292 692527 When added to the lower chamber , [TNF-alpha] also *induced* production unaffected by the addition of PFC to the upper chamber . Positive_regulation TNF IL8 10822085 694696 [TNF-alpha] *induced* expression of both and GM-CSF , without detectable production of RANTES . Positive_regulation TNF IL8 10916108 716725 [Tumor necrosis factor-alpha] , IL-6 , and *increased* at the time of rejection dx ( P < or = 0.01 ) . Positive_regulation TNF IL8 10979965 729852 In purified eosinophils primed with granulocyte-macrophage colony stimulating factor , both [tumor necrosis factor alpha (TNF-alpha)] and HrHRF *induced* increased secretion of . Positive_regulation TNF IL8 11285034 799723 Further , the treatment of endometrial carcinoma cells with inflammatory cytokines , IL-1beta and tumor necrosis factor-alpha (TNF-alpha) , demonstrated that IL-1beta and [TNF-alpha] *induced* expression in endometrial cancer cells . Positive_regulation TNF IL8 11554784 859926 [TNF-alpha] *induced* the release of ( P < 0.01 ) and IL-6 ( P < 0.05 ) from the duodenal explants . Positive_regulation TNF IL8 11989790 936379 [TNF-alpha] *induced* a 95-fold increase in and an 84-fold increase in MCP-1 levels , as compared to the controls . Positive_regulation TNF IL8 12192111 980863 However , [TNF-alpha] *induced* mRNA expression , and co-culture of TNF-alpha treated HT-29 cells with L. plantarum 299v significantly increased IL-8 mRNA expression above levels induced by TNF-alpha alone in an adhesion dependent manner . Positive_regulation TNF IL8 12379764 997314 GROalpha does not seem to initiate [TNFalpha] , IL-1beta , and IL-8 in an early phase , but *induces* IL-1beta and in a late phase . Positive_regulation TNF IL8 12574206 1057805 We hypothesize that [TNFalpha] may *induce* production in endometriotic cells through nuclear factor-kappa B (NF-kappa B) activation . Positive_regulation TNF IL8 12753503 1090312 [Tumour necrosis factor-alpha (TNF-alpha)] and IL-1beta *induced* mesothelial cell mRNA expression , and neutralizing anti-TNF-alpha antibody and IL-1 receptor antagonist nearly completely obliterated CoMTB induced mesothelial cell IL-8 mRNA expression and protein secretion . Positive_regulation TNF IL8 12792762 1097863 [TNF-alpha] and TNF-beta *induced* a 3- to 24-fold increase in protein expression of BEC , and a 2- to 8-fold increased IL-8 expression in estrogen independent BCC cell lines and no significant IL-8 expression in estrogen dependent cell lines . Positive_regulation TNF IL8 12900342 1121100 Interleukin (IL)-1beta , [tumor necrosis factor alpha (TNF-alpha)] , and *increased* significantly in TAAA patients but not in controls , peaking at 24 hours postoperatively and correlating closely with the degree of complement activation . Positive_regulation TNF IL8 12911858 1122178 The [TNF-alpha] in plasma may partially *induce* transcription of IL-6 and , which contribute to the CD14 independent increase in level of mRNA for IL-6 and IL 8 . Positive_regulation TNF IL8 1434539 204644 However , alpha-thrombin synergistically enhanced the PMNL infiltration *induced* by IL-1 alpha , [TNF-alpha] , but not that induced by zymosan activated plasma ( C5a ) or ( neutrophil activating peptide-1 ) . Positive_regulation TNF IL8 14720196 1197745 [TNF-alpha] was particularly related with angiogenesis and cartilage destruction and was *involved* in the acute stage of inflammation . Positive_regulation TNF IL8 14871353 1208155 However , type II P. gingivalis infection showed statistically higher levels of IL-1beta , , IL-12 and [tumor necrosis factor-alpha] mRNA *induction* than those of control at 24 h postinfection , whereas type I P. gingivalis and A. naeslundii showed no significant induction of these cytokines . Positive_regulation TNF IL8 15005855 1217519 Ion/PMA and [TNF-alpha] *induced* mRNA expression . Positive_regulation TNF IL8 15211029 1262152 We observed constitutive expression of interleukin (IL)-6 , , granulocyte macrophage colony stimulating factor ( GM-CSF ) , and monocyte chemoattractant protein (MCP)-1 in both human and baboon endothelial cells , and these cytokines were further *induced* by [TNF-alpha] and LPS . Positive_regulation TNF IL8 15248214 1271195 CD14+ RA synovial cells stimulated with rsCD154 plus interferon-gamma (IFNgamma) *induced* significantly higher production of IL-6 , , and monocyte chemoattractant protein 1 by FLS compared with unstimulated CD14+ synovial cells , through [TNFalpha-] , IL-1alpha- , and IL-1beta mediated pathways . Positive_regulation TNF IL8 15513871 1328332 Human neutrophil chemotaxis and transmigration were determined in vitro in *response* to and/or [TNF-alpha] . Positive_regulation TNF IL8 15517620 1328657 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL8 15652492 1364237 [TNF-alpha] *induces* and endothelin-1 expression in human endothelial cells with different redox pathways . Positive_regulation TNF IL8 15652492 1364242 By Northern blot analysis , [TNF-alpha] at 50 , 100 , 200 , and 400 U/ml significantly *induced* mRNA expression by 206 % , 252 % , 211 % , and 158 % , respectively , as compared to controls ( p < 0.05 ) . Positive_regulation TNF IL8 15652492 1364253 Thus , [TNF-alpha] significantly *induces* both and ET-1 gene expression in HMECs possibly through different redox signaling pathways . Positive_regulation TNF IL8 15746434 1403264 Human recombinant [tumor necrosis factor (TNF)-alpha] and IL-1alpha could *induce* expression in lung cancer cells in a dose dependent manner . Positive_regulation TNF IL8 1598496 188843 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL8 16175346 1461821 [TNF-alpha] and IL-1beta are early regulators of the immune response and both *induce* the release of secondary cytokines , such as IL-6 and . Positive_regulation TNF IL8 16353157 1526372 We show that phenoxodiol inhibits hallmarks of endothelial cell activation , namely [TNF] or IL-1 *induced* E-selectin and VCAM-1 expression and secretion . Positive_regulation TNF IL8 16413378 1513955 [TNF-alpha] and IL-1beta ( 0.01 to 100 ng/mL ) *induced* secretion of , IL-6 , and RANTES in a dose and time dependent manner . Positive_regulation TNF IL8 1729366 180968 By using a specific RIA , we demonstrate that not only IL-1 beta , but also [TNF-alpha] and LPS can *induce* abundant secretion from chondrocytes . Positive_regulation TNF IL8 17306937 1705211 , a C-X-C chemokine , is *induced* by [TNF-alpha] and initiates injury by acting as a chemoattractant for neutrophils and other immune cells . Positive_regulation TNF IL8 17306937 1705215 We found that [TNF-alpha] *induced* mRNA levels by increasing gene transcription , and the stability of IL-8 mRNA was not affected . Positive_regulation TNF IL8 17558435 1773937 In the absence of agonist , SR144528 by itself reduced [TNF-alpha] *induced* release . Positive_regulation TNF IL8 17711487 1794624 LPS and [TNF-alpha] *induced* release in all three cell lines and this induction was inhibited by both dexamethasone and triamcinolone . Positive_regulation TNF IL8 18258304 1884769 Here we report that [TNF] *induced* pro-inflammatory cytokine synthesis of IL-6 and is mediated by the Rho GTPase Rac . Positive_regulation TNF IL8 18475720 407267 Initial studies demonstrated that [TNF-alpha] *induced* the upregulation of and MCP-1 mRNA and protein . Positive_regulation TNF IL8 18611594 290013 IL-1alpha and [TNFalpha] *induce* the secretion of IL-6 and and the upregulation of mRNAs for IL-1alpha , IL-1beta , IL-6 and IL-8 . Positive_regulation TNF IL8 19170965 2027673 [TNF-alpha] *induced* significantly increased levels of and TNF-alpha itself in both cell lines suggesting recruitment and activation of immune cells in the underlying mucosa in vivo . Positive_regulation TNF IL8 19671412 2119501 [TNF-alpha] ( 1 microg/L ) strongly *induced* the production of IL-6 and as compared with the control serum in A549 cells , and the induced cytokine production was significantly suppressed by 15 % serum containing Feiyanning Decoction ( P < 0.01 ) . Positive_regulation TNF IL8 19874800 2196911 CSM and [TNF-alpha] *induce* a dose- and time dependent increase in production . Positive_regulation TNF IL8 20053934 2225388 [TNFalpha] stimulation *induced* production of inflammatory cytokines such as IL-6 and in RSF , and the extent of IL-6 and IL-8 induction was dramatically reduced by CHPD under noncytotoxic concentrations . Positive_regulation TNF IL8 20065153 2201196 RT-PCR showed a strong [tumor necrosis factor] alpha mRNA *increase* with that was blocked by aldosterone , excluding the possibility that the tumor necrosis factor alpha increase was merely a consequence of secretion . Positive_regulation TNF IL8 20069129 2177875 These results suggest that ticlopidine decreased [TNF-alpha] *induced* MCP-1 , , and VCAM-1 levels in HUVECs , and monocyte adhesion . Positive_regulation TNF IL8 20185130 2281454 We found that 5'-NIO inhibited [TNF-alpha] *induced* MCP-1 and expression at the RNA and protein levels in HUVECs . Positive_regulation TNF IL8 20493505 2367814 Lipopolysaccharide was a more potent inducer of IL-1ß and than LTA or PG and LTA is a more potent inducer of CXCL-8 than PG. Based on these data , PAMPs from gram positive and negative bacteria *induce* [TNF] , IL-1ß and CXCL-8 production in feline whole blood . Positive_regulation TNF IL8 20657842 2293426 [TNF-alpha] *induced* a robust activation of MMP-9 , ICAM-1 , and the promoter driven reporter in Thy-1- MEFs , in contrast to only a modest increase in Thy-1+ counterparts . Positive_regulation TNF IL8 20665032 2531490 Nicotine inhibits [tumor necrosis factor-a] *induced* IL-6 and secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis . Positive_regulation TNF IL8 20827577 2325246 [TNF-a] *induces* vectorial secretion of in Caco-2 cells . Positive_regulation TNF IL8 21113640 2407582 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL8 2113076 135529 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL8 2185985 132001 [Tumour necrosis factor (TNF)] and LPS , unlike the inflammatory monokine IL-6 , also *induced* expression . Positive_regulation TNF IL8 21871585 2510367 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL8 2250017 146053 Among cytokines , only IL-1 and [tumor necrosis factor (TNF)] can *induce* gene expression at the transcriptional level . Positive_regulation TNF IL8 22697068 2615683 Indeed , differentiated THP-1 cell exposures ( i ) to 5 and 10 microM of combination of NP and DiP induced an level in the medium respectively of 28.9 and 45 percent higher than the level obtained for the control ( untreated cells ) , ( ii ) to combination of NP and DiP at 10 microM induced an increase of IL-1ß level in comparison to the control level , ( iii ) to combination of NP and DiP *induced* an increase of [TNF-a] level whatever the concentration of EDCs tested ( between 0 and 10 microM ) . Positive_regulation TNF IL8 22870498 2641400 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL8 22926119 2657902 Pretreatment of HT-29 cells with LGG significantly blocked [TNF-a] , and LPS *induced* activation at both mRNA and protein level ( p < 0.05 ) . Positive_regulation TNF IL8 22995521 2689027 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL8 23702712 2792434 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL8 2404745 128024 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL8 2471522 111739 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL8 24751878 2943440 LDN-193189 *prevented* BMP4 mediated inhibition of basal and [tumor necrosis factor] a-stimulated expression of in AGS cells . Positive_regulation TNF IL8 24905701 2952071 Furthermore , HMGB1 and IL-1ß and/or [tumor necrosis factor] a ( but not HMGI/Y ) also significantly *induced* inducible nitric oxide synthase , NO , and production in human cartilage and chondrocytes . Positive_regulation TNF IL8 3011946 59741 Tumor necrosis [factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL8 3260265 94484 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL8 3486936 60083 [Tumor necrosis factor] ( cachectin ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL8 3526909 62633 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL8 7536712 300189 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL8 7600258 311519 However , PMA and [TNF alpha] *induced* production that coincided with significant cell cycle inhibition . Positive_regulation TNF IL8 7600258 311522 At all concentrations tested , [TNF alpha] reduced the mitotic index by approximately 45 % , slowed cell cycle progression by approximately 3.5 h , and *induced* a flat , albeit large , response at concentrations > or = 12.5 ng/ml . Positive_regulation TNF IL8 7756650 307519 *had* no effect on IL-6R and TNF-alpha R , or on [TNF-alpha] and IL-6 production in these cells . Positive_regulation TNF IL8 7875467 298278 [TNF-alpha] and IL-1 beta dose-dependently *induced* production in HT-29 cells . Positive_regulation TNF IL8 7981153 281387 Unexpectedly , IL-1 alpha and [TNF-alpha] efficiently *induced* production and IL-8 mRNA in NPD type A fibroblasts as in normal fibroblasts . Positive_regulation TNF IL8 8132326 251507 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL8 8333833 223726 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL8 8592105 341952 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL8 8624246 360187 In the same cultures , [tumor necrosis factor-alpha] *induced* marked increases in release of both and IL-6 at 24 and 48 h after stimulation . Positive_regulation TNF IL8 8832978 385879 Our data suggest that [TNF-alpha] *induces* expression of proinflammatory cytokines such as and MCP-1 through generation of reactive oxygen intermediates and subsequent activation of NF-kappa B in human synovial cells , and the antioxidants may inhibit , at least in part , the activation of NF-kappa B by TNF-alpha . Positive_regulation TNF IL8 8873050 389813 A pronounced increase of mRNA expression and protein production was *induced* by [tumour necrosis factor-alpha (TNF alpha)] . Positive_regulation TNF IL8 8900181 393434 Synergistic *activation* of gene transcription by all-trans-retinoic acid and [tumor necrosis factor-alpha] involves the transcription factor NF-kappaB . Positive_regulation TNF IL8 9164965 432159 Although IL-1 and [TNF-alpha] also *induce* and E-selectin , the thrombin effects in these experiments were not mediated by those cytokines , since neither IL-1 receptor antagonist nor anti-TNF-alpha Ab inhibited the effects of thrombin . Positive_regulation TNF IL8 9407069 470797 Northern blot analysis revealed that [TNFalpha] *induced* both ICAM-1 and expression in either the A549 lung epithelial cell line or the human microvessel endothelial cell line ( HMEC-1 ) . Positive_regulation TNF IL8 9407069 470800 [TNFalpha] *induced* greater gene expression as compared with H2O2 , but the kinetics of induction were similar . Positive_regulation TNF IL8 9427069 472688 is *involved* in homologous [TNF alpha-] , but not in IL-1 beta induced neutrophil infiltration in rabbits . Positive_regulation TNF IL8 9427069 472690 Administration of [TNF alpha] or IL-1 beta *induced* production ; Positive_regulation TNF IL8 9548401 498871 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF IL8 9594359 505924 Activation by [tumor necrosis factor-alpha] *induced* production by B lymphocytes . Positive_regulation TNF IL8 9657919 516881 IL-1beta and [TNF-alpha] synergistically *induced* IL-6 and GM-CSF and additively induced and MCP-1 production , while IL-2 , IL-10 , IFN-alpha , and IFN-gamma had little or no additional effects . Positive_regulation TNF IL8 9698598 524964 These studies show that inhibition of proteasome mediated IkappaB degradation results in inhibition of [TNF-alpha] *induced* production in A549 cells by limiting NF-kappaB mediated gene transcription . Positive_regulation TNF IL8 9830008 551245 H2O2 and [tumor necrosis factor-alpha] *induce* differential binding of the redox-responsive transcription factors AP-1 and NF-kappaB to the promoter in endothelial and epithelial cells . Positive_regulation TNF IL8 9830008 551266 Unlike H2O2 , the proinflammatory cytokine [TNFalpha] *induced* and ICAM-1 in both cell types . Positive_regulation TNF IL8 9893037 558643 IL-1beta and [TNF-alpha] *induced* the synthesis of at 24 hr , but partially inhibited the synthesis at 48 hr . Positive_regulation TNF IL9 15517620 1328658 When RA FLS are stimulated with 1 or [tumor necrosis factor-a] , WISP3 mRNA is significantly *increased* . Positive_regulation TNF IL9 1598496 188844 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Positive_regulation TNF IL9 21113640 2407583 HO-1 protein levels in cultured media of RASFs were increased by *stimulation* by at 6 h and [tumor necrosis factor-alpha] at 12 h , but suppressed by interferon-gamma at 12 and 24 h . Positive_regulation TNF IL9 2113076 135530 *induces* [tumor necrosis factor (TNF)] in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits . Positive_regulation TNF IL9 21871585 2510368 On day 2 , [tumor necrosis factor (TNF)-a] production in BALF was also reduced significantly , but interferon-a , , and interferon-? productions were *augmented* and natural killer ( NK ) cell activity was significantly elevated . Positive_regulation TNF IL9 22870498 2641401 These children now receive more targeted treatment including the [tumor necrosis factor] alpha ( TNFa ) *inhibitors* , blockade , interleukin-6 blockade , selective costimulation modulators and selective B-cell blockade . Positive_regulation TNF IL9 22995521 2689028 Interestingly , although neither [tumor necrosis factor-a] nor interferon-? induced cholesterol trafficking , *induced* [ ( 14 ) C ] cholesteryl ester accumulation that was also dependent upon sPLA ( 2 ) and sphingomyelinase activities . Positive_regulation TNF IL9 23702712 2792435 Enzyme linked immunosorbent assay and AP assay showed *induced* [TNF-a] shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells . Positive_regulation TNF IL9 2404745 128025 Human osteoblast cultures derived as out-growths from trabecular bone released [tumor necrosis factor] ( TNF alpha ) upon *stimulation* of the cells with human recombinant 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ) , human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ) , and bacterial lipopolysaccharide ( 5-500 ng/ml ) . Positive_regulation TNF IL9 2471522 111740 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Positive_regulation TNF IL9 3011946 59742 [Tumor necrosis factor/cachectin] interacts with endothelial cell receptors to *induce* release of 1 . Positive_regulation TNF IL9 3260265 94485 Molecular cloning of a human monocyte derived neutrophil chemotactic factor ( MDNCF ) and the *induction* of MDNCF mRNA by 1 and [tumor necrosis factor] . Positive_regulation TNF IL9 3486936 60084 Tumor necrosis factor ( [cachectin] ) is an endogenous pyrogen and *induces* production of 1 . Positive_regulation TNF IL9 3526909 62634 Endotoxin and [tumor necrosis factor] *induce* gene expression in adult human vascular endothelial cells . Positive_regulation TNF IL9 7536712 300190 Furthermore , 8-Br-cGMP enhanced the *induced* increase in [tumor necrosis factor-alpha] messenger RNA level in vascular smooth muscle cells . Positive_regulation TNF IL9 8132326 251508 Moreover , pretreatment of macrophages with recombinant TNF for 3 h enhances [TNF] and *induces* production in response to both forms of Candida , while pretreatment for 18 h renders macrophages refractory to any stimuli . Positive_regulation TNF IL9 8333833 223727 *induction* of tumor necrosis factor-alpha mRNA and bioactive [tumor necrosis factor-alpha] in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis . Positive_regulation TNF IL9 8592105 341953 The present study establishes that [tumor necrosis factor-alpha (TNF-alpha)] induction of sympathetic substance P ( SP ) *requires* sequential induction of both ( IL-1 ) and leukemia inhibitory factor (LIF) . Positive_regulation TNF IL9 9548401 498872 Production of [tumor necrosis factor-alpha] and the lysosomal cysteine proteinase cathepsin B were markedly inhibited , but production of *increased* . Positive_regulation TNF INHBA 10433499 634017 Further , the release of [TNFalpha] in the *presence* of was potentiated by tyrosine kinase inhibition . Positive_regulation TNF INHBA 1417851 201650 [Tumor necrosis factor] and interleukin-1 *induce* gene expression in a human bone marrow stromal cell line . Positive_regulation TNF INHBA 1417851 201705 In a human bone marrow derived stromal cell line , KM-102 , phorbol myristate acetate , [tumor necrosis factor-alpha] and interleukin-1 beta *induced* great increases in beta A chain mRNA levels and production of activities . Positive_regulation TNF INHBA 15893868 1481294 On the other hand , [TNF-alpha] secretion significantly increased in *presence* of but not of inhibin A . Positive_regulation TNF INHBA 21640344 2450966 is *induced* by interleukin-1ß and [tumor necrosis factor-a] and enhances the mRNA expression of interleukin-6 and protease activated receptor-2 and proliferation of stromal cells from endometrioma . Positive_regulation TNF INHBA 23116663 2717433 Release of activin A from isolated BMNPs was stimulated by [TNF-a] , but this was not *due* to increased production . Positive_regulation TNF INHBA 23171678 2775238 In cultured EoSCs , interleukin 1ß (IL-1ß) and [tumor necrosis factor-a (TNF-a)] , which could *induce* , also induced follistatin messenger RNA ( mRNA ) and protein . Positive_regulation TNF INPP5D 15701712 1409590 Neither disrupting phosphatase activity nor using the PI-3K pathway inhibitor LY294002 or wortmannin could significantly block *mediated* inhibition of LPS induced ERK1/2 , p38 , and JNK activation and [TNF-alpha] production , demonstrating that SHIP1 inhibits LPS induced activation of MAPKs and cytokine production primarily by a phosphatase activity- and PI-3K independent mechanism . Positive_regulation TNF INS 10521443 652779 *increased* the expression of [tumor necrosis factor] receptor associated factor 2 ( TRAF2 ) mRNA and protein in Chinese hamster ovary cells overexpressing insulin receptors (IRs) . Positive_regulation TNF INS 10545284 564476 In conclusion , data presented suggest that might *regulate* superoxide generation and [TNF-alpha] release by leukocytes upon exposure to LPS in vivo . Positive_regulation TNF INS 11443108 850417 The results of array analysis showed that *stimulated* gene expression of [tumor necrosis factor-alpha (TNF-alpha)] the most among all genes in the analysis . Positive_regulation TNF INS 11443108 850419 These observations indicate that insulin stimulates TNF-alpha production in macrophages by regulating the expression of TNF-alpha mRNA and that the extracellular signal regulated kinase signaling pathway may have a critical role in stimulating the production of [TNF-alpha] in *response* to in macrophages . Positive_regulation TNF INS 11978647 934655 *stimulated* [TNF-alpha] secretion in a dose dependent manner ( P < 0.01 ) ; Positive_regulation TNF INS 12610836 1029993 The expression of [tumor necrosis factor] alpha induced protein 6 ( TNFAIP 6 ) was more *enhanced* , while growth factor binding protein 5 ( IGFBP 5 ) was less expressed in keratoconus patients . Positive_regulation TNF INS 14532168 1185891 *stimulates* interleukin-6 and [tumor necrosis factor-alpha] gene expression in human subcutaneous adipose tissue . Positive_regulation TNF INS 15365619 1334209 Rosiglitazone treatment impaired [TNF-alpha] *activation* of p38 and p42/p44MAPK , restoring signalling and leading to normalisation of glucose uptake . Positive_regulation TNF INS 15837949 1397973 Insulin increased TNF-alpha secretion in a concentration dependent manner ( P < 0.01 ) , whereas RSG ( 10 nmol/L ) significantly reduced the *mediated* rise in [TNF-alpha] ( P < 0.001 ) , as well as angiotensin and angiotensin II . Positive_regulation TNF INS 17158207 1694197 [TNFalpha] increased serine/threonine phosphatase activity of protein phosphatase 1 (PP1) in *response* to C6 , but not , suggesting a ceramide-specific effect . Positive_regulation TNF INS 17471172 1761328 Crocetin blocked the impaired *stimulated* glucose uptake and disordered [TNF-alpha] and adiponectin expression induced by palmitate in rat adipocytes . Positive_regulation TNF INS 17636085 1770710 Postprandial insulin and glucose concentrations , and *stimulated* serine/threonine protein kinase ( Akt ) , insulin receptor activation , and [tumor necrosis factor-alpha] concentrations in subcutaneous fat and muscle were measured in subsets of animals . Positive_regulation TNF INS 19208910 2061483 These cells produced interferon-gamma and [tumor necrosis factor-alpha] in *response* to peptide and were cytotoxic to insulin peptide coated targets . Positive_regulation TNF INS 1932101 169986 It is concluded that PAF and [TNF-alpha] can increase hepatic lipogenesis in vivo in the absence of adrenal hormones and in the *presence* of a low plasma . Positive_regulation TNF INS 21054880 2349382 We have examined whether saturated nonesterified fatty acids ( NEFA ) and , which increase in concentration with developing insulin resistance , can *trigger* the production of interleukin (IL)-6 and [tumor necrosis factor (TNF)-a] in human monocytes . Positive_regulation TNF INS 8908396 394506 The production of [TNF-alpha] and IL-6 by the macrophages of the patient in *presence* of were dramatically increased in comparison with control subjects . Positive_regulation TNF INS 8986132 404007 However , ebselen failed to prevent the increase in nitrite production and the decrease in glucose oxidation and release by rat islets exposed to IL-1 beta for 24 hr. Ebselen *prevented* the increase in nitrite production by human islets exposed for 14 hr to a combination of cytokines ( IL-1 beta , [tumor necrosis factor-alpha] and interferon-gamma ) . Positive_regulation TNF INS 9545516 499268 Glycophosphatidyl inositol membrane anchors of parasite proteins possess like activity and *induce* [TNF] synthesis . Positive_regulation TNF INSR 10320052 612091 However , we found an approximately 2-fold increase in insulin stimulated tyrosine phosphorylation of the insulin receptor in the muscle and adipose tissue of TNF-alpha knockout mice , suggesting that signalling is an important *target* for [TNF-alpha] . Positive_regulation TNF INSR 7559552 323940 [Tumor necrosis factor] alpha *induced* phosphorylation of . Positive_regulation TNF INTS2 17202359 1681030 Using flow cytometry to assess TLR induced cytokine production , we observed a substantial , highly significant defect *induced* [TNF-alpha] ( p = 0.0003 ) and IL-6 ( p < 0.0001 ) production , in older adults compared with young controls . Positive_regulation TNF INTS3 2229314 144598 Compared with the control experiment , [TNF] *induced* significant decreases ( -36 +/- 2 % ; saline , -20 +/- 3 % ; Positive_regulation TNF IRAK1 11698503 878199 However , neither [TNF-alpha] nor IL-1beta *induced* degradation or stimulated TNF-alpha or TxB2 production in naive cells . Positive_regulation TNF IRAK1 12620219 1066173 Furthermore , recent data imply a *role* for in [tumor necrosis factor receptor (TNFR)] superfamily induced signaling pathways as well . Positive_regulation TNF IRAK1 16024789 1435412 Overexpression of suppressed NF-kappaB activation and *blocked* IL-1beta induced IL-6 as well as lipopolysaccharide- and CpG induced [tumor necrosis factor] alpha production in multiple cellular systems . Positive_regulation TNF IRAK2 11698503 878200 However , neither [TNF-alpha] nor IL-1beta *induced* degradation or stimulated TNF-alpha or TxB2 production in naive cells . Positive_regulation TNF IRAK2 23918981 2830766 In bone marrow derived macrophages ( BMDMs ) , the interaction was *required* for the late ( 2-8 h ) but not the early phase ( 0-2 h ) of il6 and [tnfa] mRNA production , and hence for IL-6 and TNF-a secretion by TLR agonists that signal via MyD88 . Positive_regulation TNF IRAK3 11698503 878196 However , neither [TNF-alpha] nor IL-1beta *induced* degradation or stimulated TNF-alpha or TxB2 production in naive cells . Positive_regulation TNF IRAK3 21098228 2372038 Without CASP-6 expression , PMN stimulation fails to cleave , degrade I?Ba , or *induce* [TNF-a] . Positive_regulation TNF IRAK4 11698503 878197 However , neither [TNF-alpha] nor IL-1beta *induced* degradation or stimulated TNF-alpha or TxB2 production in naive cells . Positive_regulation TNF IRAK4 15483191 1354715 TNF receptor p55 (TNFRp55) and type I ( IL-1RI ) *mediate* the biological functions of [TNF-alpha] and IL-1beta , respectively . Positive_regulation TNF IRF1 16978650 1633553 We hypothesized that [TNF-alpha] would *induce* and p53 protein binding in pancreatic acinar cells and that PYY would attenuate the effect . Positive_regulation TNF IRF1 8746784 343502 We demonstrated here that [TNF-alpha] induced binding of NF kappa B p50 and p65 to the NF kappa B-like element of the MHC class I promoter termed region I and IFN-gamma *induced* binding of to the adjacent interferon consensus sequence ( ICS ) . Positive_regulation TNF IRF1 9973374 596002 We previously reported that IFN-gamma and [TNF-alpha] *induce* production of the transcription factor in HT-29 cells and that IRF-1 binds to an element in exon 1 of the PIGR gene . Positive_regulation TNF IRF3 17328045 1711885 Antiviral gene expression in RA , especially due to TLR ligands and [TNFalpha] , is *dependent* on IKKepsilon and , and this pathway plays a key role in the production of type I IFNs and chemokines such as RANTES . Positive_regulation TNF IRF5 18332133 1904717 In addition , *regulates* [TNFalpha] but not type I interferon gene transcription in Newcastle disease virus infected peritoneal macrophages . Positive_regulation TNF IRF5 20237317 2265970 is *required* for late-phase [TNF] secretion by human dendritic cells . Positive_regulation TNF IRF5 20237317 2265972 In this study , we define the *role* for in secretion of [tumor necrosis factor (TNF)] by human dendritic cells (DCs) . Positive_regulation TNF IRF5 22995936 2694235 Knockdown of KAP1 ( TRIM28 ) gene expression in human M1 macrophages potentiated *mediated* expression of [TNF] and other M1 macrophage markers . Positive_regulation TNF IRF7 16537619 1536818 IFN-alpha and [TNF-alpha] *induced* the expression of the RIG-I , TLR3 , MyD88 , TRIF , and genes , whereas no detectable TLR7 and TLR8 was seen in A549 cells . Positive_regulation TNF IRS1 7559552 323948 Our data suggest that [TNF] *induces* serine phosphorylation of through inhibition of serine phosphatases or activation of serine kinases other than protein kinase C . Positive_regulation TNF ITGA2 12815041 1120755 Moreover , GPIb inhibits the [TNF alpha] production *induced* by T. gondii GPI or by . Positive_regulation TNF ITGA2B 9878125 557715 In combination , IFN-gamma and [TNF-alpha] *induce* a maximal level of and CD42 expression which is also accompanied by an increase in cell size and DNA ploidy level . Positive_regulation TNF ITGA5 9230816 444775 Ligation of *upregulates* [TNF-alpha] receptor expression , whereas binding of CD49f downregulates IL-1 beta receptor expression . Positive_regulation TNF ITGA6 8871661 389613 Cross linking of adherent PMN very late antigen (VLA)-5 and receptors *resulted* in a progressive increase in [TNF-alpha] ( p60 , p80 ) and IL-8R expression during hypoxia ; Positive_regulation TNF ITGAE 22611024 2691429 In rats with Bact-DNA in MLNs without GBT , intestinal and MLNs ( + ) -DCs showed features of activation , expansion of the proinflammatory CD4 ( + ) -DC subpopulation , *augmented* [TNF-a] production , and increased phagocytic and migratory capacities . Positive_regulation TNF ITGAL 21206905 2359243 siRNA mediated knockdown of either Rac1 or Rac2 prevented *stimulated* stabilization of the labile transcripts encoding IFN-? and [TNF-a] , and integrin mediated IFN-? mRNA stabilization was absent in T cells obtained from Rac2 gene deleted mice . Positive_regulation TNF ITGAL 7491985 332387 In conclusion , 1 ) , ICAM-1 , and CINC play major roles in the LPS initiated emigration of PMNs into the bronchoalveolar space , and 2 ) the [TNF] that drives ICAM-1 and CINC expression is *derived* largely from alveolar macrophages rather than PMNs . Positive_regulation TNF ITGAM 10843415 700074 TNF-alpha caused a significant increase in PMNL CD 11b/CD18 expression after 30 min of incubation at 37 degrees C . [TNF-alpha] added simultaneously with the bacteria *induced* a significant increase in PMNL in both strains . Positive_regulation TNF ITGAM 17197441 1702255 Additionally , [TNF-alpha] *induced* the association of with the NADPH oxidase subunit Nox2 ( gp91(phox) ) and phosphorylation of p47(phox) , indicating the CD11b/CD18 dependence of NADPH oxidase activation . Positive_regulation TNF ITGAM 17310399 1740782 On the other hand , Fr. B ( intracellular polysaccharides ) only moderately *induced* [TNF-alpha] release , expression , and phagocytosis at the same concentrations . Positive_regulation TNF ITGAV 10992470 732917 The monocyte was *involved* in [TNF] synthesis since peptides containing RGD sequences and blocking antibodies against alpha(v)beta(3) integrin inhibited TNF transcripts induced by C. burnetii . Positive_regulation TNF ITGAV 10992470 732921 Nevertheless , the cross linking of by specific antibodies was not *sufficient* to induce [TNF] synthesis . Positive_regulation TNF ITGB1 10594567 573070 Furthermore , in BD a significantly increased proportion of the gammadelta T cell population expressed CD69 and high levels of and were *induced* to produce IFN-gamma and [TNF-alpha] compared with healthy controls . Positive_regulation TNF ITGB2 10843415 700075 TNF-alpha caused a significant increase in PMNL CD 11b/CD18 expression after 30 min of incubation at 37 degrees C . [TNF-alpha] added simultaneously with the bacteria *induced* a significant increase in PMNL in both strains . Positive_regulation TNF ITGB2 16455966 1522314 Abrogation of HuR function by use of inhibitory peptides , or marked reduction of HuR levels by RNA interference , prevents engagement *mediated* stabilization of T cell [TNF-alpha] or IFN-gamma transcripts , respectively . Positive_regulation TNF ITGB2 17197441 1702256 Additionally , [TNF-alpha] *induced* the association of with the NADPH oxidase subunit Nox2 ( gp91(phox) ) and phosphorylation of p47(phox) , indicating the CD11b/CD18 dependence of NADPH oxidase activation . Positive_regulation TNF ITGB2 9759893 536641 As expected , cross linking of on macrophages with Ab *resulted* in generation of [TNF-alpha] and MIP-2 . Positive_regulation TNF ITGB3 10992470 732918 The monocyte was *involved* in [TNF] synthesis since peptides containing RGD sequences and blocking antibodies against alpha(v)beta(3) integrin inhibited TNF transcripts induced by C. burnetii . Positive_regulation TNF ITGB3 10992470 732922 Nevertheless , the cross linking of by specific antibodies was not *sufficient* to induce [TNF] synthesis . Positive_regulation TNF ITIH4 11306633 804264 Intrathecal produced time dependent , site-specific *increases* in [TNF] and IL-1 protein release into lumbosacral CSF ; Positive_regulation TNF ITIH4 12372982 996507 Exposure to *results* in [tumor necrosis factor-alpha (TNF)] upregulation , particularly in cells of monocyte lineage . Positive_regulation TNF ITIH4 16081599 1460322 HIV-1 *induced* [TNF-{alpha] } production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen activated protein (MAP) kinase pathways . Positive_regulation TNF ITIH4 16081599 1460324 MDM exposure to recombinant macrophage-tropic ( R5 ) *led* to dose- and donor dependent release of [TNF-alpha] , which was cyclohexamide-sensitive and associated with up-regulated message . Positive_regulation TNF ITIH4 16873189 655754 Human immunodeficiency virus type 1 envelope glycoprotein *induces* [tumor necrosis factor-alpha] in astrocytes . Positive_regulation TNF ITIH4 16873189 655756 *induction* of the inflammatory cytokine [tumor necrosis factor-alpha (TNF-alpha)] was studied in cultures of purified astrocytes . Positive_regulation TNF ITIH4 16989980 1746969 These studies demonstrate that : ( a ) intrathecal upregulates meningeal gene expression of proinflammatory signals , including tumor necrosis factor-alpha (TNF-alpha) , interleukin-1beta (IL-1beta) , interleukin 6 (IL-6) , and inducible nitric oxide synthase (iNOS) , and ( b ) intrathecal gp120 *induces* meningeal release of [TNF-alpha] , IL-1beta , and IL-6 . Positive_regulation TNF ITIH4 16989980 1746972 In addition , stimulation of isolated meninges in vitro with *induced* the release of [TNF-alpha] and IL-1beta , indicating that the resident cells of the meninges are able to respond without immune cell recruitment . Positive_regulation TNF ITIH4 17204394 1747173 gp120 induces the release of interleukin-6 (IL-6) , in addition to IL-1 and TNF , the present study tested whether this IL-6 release in spinal cord contributes to *induced* mechanical allodynia and/or to gp120 induced increases in [TNF] and IL-1 . Positive_regulation TNF ITIH4 17396998 1721177 Progesterone inhibits the induction of TNF synthesis by viral infection and virus or *induced* [TNF] transcription . Positive_regulation TNF ITIH4 1918999 168461 Recombinant specifically *enhances* [tumor necrosis factor-alpha] production and Ig secretion in B lymphocytes from HIV infected individuals but not from seronegative donors . Positive_regulation TNF ITIH4 1918999 168462 this secretion was augmented by the presence of gp120 , whereas B cells from healthy seronegative donors failed to secrete significant levels of [TNF-alpha] in the *presence* or absence of . Positive_regulation TNF ITIH4 2335821 133761 Our studies indicate that , in the absence of endotoxin , HIV-1 , HIV-2 , and HIV do not *induce* production of IL-1 beta , IL-6 , or [TNF-alpha] by peripheral blood mononuclear cells . Positive_regulation TNF ITIH4 23539626 2782570 We show that inhibition of Wnt5a by specific antagonists blocks induced *up-regulation* of IL-1ß , IL-6 , and [TNF-a] in the spinal cord . Positive_regulation TNF ITIH4 23936448 2826944 We found that HIV-1 profoundly *induced* N9 cells to produce reactive oxygen species ( ROS ) , [tumor necrosis factor-a (TNF-a)] and monocyte chemoattractant protein-1 ( MCP-1 ) . Positive_regulation TNF ITIH4 7704970 297590 Hence , FL may cause TNF release from lymphocytes by binding to CD4 , while rp120cd interacts with monocytes but not lymphocytes and *induces* [TNF] production by a mechanism not involving CD4 binding . Positive_regulation TNF ITIH4 8070847 270146 Thus , *induction* of [TNF] by may be associated with impairment of antigen presenting capacity of monocytes seen in AIDS patients . Positive_regulation TNF ITIH4 9070311 419202 *increased* IL-1 beta , IL-1Ra , [TNF-alpha] , and TGF-beta 1 mRNAs . Positive_regulation TNF ITIH4 9218822 442332 On the other hand , inhibition of the mixed lymphocyte reaction (MLR) in CD4+ T cells by gp120 , which may be related to gp120 mediated down-regulation of CD4 expression on T cells and activation of protein tyrosine kinase p56 ( lck ) in CD4+ T cells , was observed even in the absence of macrophage derived [TNF-alpha] *induced* by . Positive_regulation TNF ITIH4 9343827 459046 Role of curdlan sulfate in the binding of HIV-1 gp120 to CD4 molecules and the production of *mediated* [TNF-alpha] . Positive_regulation TNF ITIH4 9343827 459049 CRDS treatment of cells not only inhibited the binding of HIV-1 gp120 to CD4+ cells , but also inhibited [TNF-alpha] production *induced* by . Positive_regulation TNF ITIH4 9700761 525258 In separate experiments on normal peripheral blood mononuclear cells ( PBMC ) , alpha-MSH ( 1-13 ) inhibited production of IL-1 beta and [TNF alpha] *induced* by HIV envelope glycoprotein . Positive_regulation TNF JAG1 15749897 1379750 Membrane also *induce* purified macrophages from noninfected individuals to secrete IL-10 and [TNF-alpha] , but have no effect on IL-1alpha or IL-12 secretion . Positive_regulation TNF JAG1 18337563 1904877 Notch signaling regulates tip cell function , and we find that [TNF] also *induces* the notch ligand , through an NFkappaB dependent mechanism . Positive_regulation TNF JAG1 23319735 2738322 Finally , IVE-TB *induced* strong IFN-? ( + ) [/TNF-a] ( + ) CD8 ( + ) and TNF-a ( + ) /IL-2 ( + ) CD154 ( + ) /CD4 ( + ) T cell responses in PBMC from long-term latently M. tuberculosis infected individuals . Positive_regulation TNF JAG2 14586405 1159557 We found that [TNF] *induced* the expression of Notch-1 , Notch-4 , and in RSF . Positive_regulation TNF JAK1 10347215 616824 Herein , we demonstrate that the ability of IL-10 to inhibit [tumor necrosis factor alpha (TNFalpha)] production in lipopolysaccharide stimulated macrophages *requires* the presence of Stat3 , , and two distinct regions of the IL-10 receptor intracellular domain . Positive_regulation TNF JAK1 11801527 902546 Here we present evidence that [TNF-alpha] *induces* the activation of the cytoplasmic Janus tyrosine kinases and Tyk2 in both human healthy peripheral and lymphoma B cells . Positive_regulation TNF JAK1 17121792 1686276 However , inhibition of *had* little effect on cmvIL-10 mediated suppression of [tumor necrosis factor alpha (TNF-alpha)] production . Positive_regulation TNF JAK1 22941906 2701711 Our findings demonstrate that inhibitors suppress macrophage activation and *attenuate* [TNF] responses and further suggest that suppression of cytokine/chemokine production and innate immunity contribute to the therapeutic efficacy of JAK inhibitors . Positive_regulation TNF JAK1 22969062 2673579 Inhibition of ( STAT1/STAT5 kinase ) with AG490 markedly *reduced* the production of IL-6 and [TNF-a] in macrophages . Positive_regulation TNF JAK1 23170143 2700349 Recent studies have shown that cerulein activated nicotinamide adenine dinucleotide phosphate oxidase elicits reactive oxygen species , which trigger the phosphorylation of the , STAT1 , and STAT3 proteins and *induce* the production of inflammatory cytokines , such as [tumor necrosis factor-a] , interleukin (IL)-1ß , and IL-6 , in pancreatic acinar cells . Positive_regulation TNF JAK1 9510175 491845 In this study , we show that murine [TNF] *induces* the tyrosine phosphorylation and activation of the intracellular Janus tyrosine kinases , Jak2 , and Tyk2 in murine 3T3-L1 adipocytes . Positive_regulation TNF JAK2 10454343 637715 In TNF-alpha treated cells , IFN-gamma induced phosphorylation of Jak2 kinase is increased , Jak2 kinase activity is enhanced , and genetic studies indicate that [TNF-alpha] *requires* kinase activity to enhance Stat1alpha tyrosine phosphorylation . Positive_regulation TNF JAK2 12426001 1014296 Inhibitors of PTK ( AG-126 ) , or ( AG-490 ) *inhibited* [TNF-alpha] and NO production , caspase 1 activation and apoptosis , suggesting that M. tuberculosis-induction of these events depends on JAK2/STAT1-alpha activation . Positive_regulation TNF JAK2 21917753 2501669 inhibition also *reduces* the production of IL-6 and [TNF-a] in allogeneic MLRs , impairing the activation of central and effector memory T cells as well as the expansion of responder Th1 and Th17 cells . Positive_regulation TNF JAK2 22941906 2701712 Our findings demonstrate that inhibitors suppress macrophage activation and *attenuate* [TNF] responses and further suggest that suppression of cytokine/chemokine production and innate immunity contribute to the therapeutic efficacy of JAK inhibitors . Positive_regulation TNF JAK2 22969062 2673580 Inhibition of ( STAT1/STAT5 kinase ) with AG490 markedly *reduced* the production of IL-6 and [TNF-a] in macrophages . Positive_regulation TNF JAK2 9510175 491846 In this study , we show that murine [TNF] *induces* the tyrosine phosphorylation and activation of the intracellular Janus tyrosine kinases Jak1 , , and Tyk2 in murine 3T3-L1 adipocytes . Positive_regulation TNF JAK3 18068105 1846998 The inhibitor had no effect on COX-2 expression , and [TNF-alpha] production was slightly *inhibited* only at higher drug concentrations ( 30 microM ) . Positive_regulation TNF JAK3 22941906 2701713 Our findings demonstrate that inhibitors suppress macrophage activation and *attenuate* [TNF] responses and further suggest that suppression of cytokine/chemokine production and innate immunity contribute to the therapeutic efficacy of JAK inhibitors . Positive_regulation TNF JAK3 22969062 2673581 Inhibition of ( STAT1/STAT5 kinase ) with AG490 markedly *reduced* the production of IL-6 and [TNF-a] in macrophages . Positive_regulation TNF JUN 10318823 611908 Forced expression of in ATF2 expressing melanoma cells *restored* [TNFalpha] expression , suggesting that both forms of ATF2 sequestered transcription factors that positively regulate TNFalpha expression in response to UV irradiation . Positive_regulation TNF JUN 10521481 653091 The study presented here shows that autoregulation of [TNF-alpha] gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 mitogen activated protein (MAP) kinase activity and the binding of the transcription factors ATF-2 and to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation TNF JUN 10601128 574170 [Tumor necrosis factor-alpha (TNF-alpha)] alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 MAPK , and N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation TNF JUN 10615065 656329 however , [TNF-alpha] *induced* both and NF-kappaB binding activities in BET-1A cells . Positive_regulation TNF JUN 10764744 698804 TNF-alpha signaling was not altered by the overexpression of catalase , as *activation* of nuclear factor kappaB and by [TNF-alpha] was similar in the three cell lines . Positive_regulation TNF JUN 10837498 699420 The following observations supported that both NF-kappaB and *mediated* enhanced [TNFalpha] transcription by CHG : 1 ) A 295-base pair fragment of the proximal TNFalpha promoter containing NF-kappaB and AP-1 sites reproduced the effects of CHG on TNFalpha transcription in a luciferase reporter assay , 2 ) mutational analyses of both NF-kappaB and the AP-1 sites abrogated 90 % of the luciferase activity , 3 ) gel-shift analysis using the binding sites showed activation of NF-kappaB and AP-1 in CHG nuclear extracts , and 4 ) Western blot analyses demonstrated elevated nuclear levels of p65 and p50 and decreased cytosolic levels of IkappaBalpha in CHG treated monocytes . Positive_regulation TNF JUN 10884313 709534 However , pretreatment with oATP downregulated *activation* of NF-kappaB and by IL-1beta or [TNFalpha] . Positive_regulation TNF JUN 10930293 719777 These observations demonstrate that , C/EBPbeta and *contribute* to the regulation of the [TNF-alpha] gene in normal macrophages following treatment with PMA . Positive_regulation TNF JUN 10954916 724650 Besides NF-kappaB , the *activation* of by [TNF] also was blocked by Bcl-x ( L ) . Positive_regulation TNF JUN 11007940 735636 [TNF-alpha] also *induces* the activation of NF-kappa B and and the subsequent increase in gamma-GCS heavy subunit transcription in these cells . Positive_regulation TNF JUN 11132130 760210 Induction of membrane bound TNFalpha was also found in c-fos gene knockout mice deficient in the AP-1 transcription factor , suggesting that , although AP-1 containing c-fos signaling is required for some UV responses , containing c-fos is not *required* for this [TNFalpha] activation . Positive_regulation TNF JUN 11753638 890158 [TNF] *induced* NF-kappaB activation but not activation in LNCaP cells . Positive_regulation TNF JUN 11880365 937206 [TNF] also *induced* a transient activation of , which upon addition of CDDO was converted to a sustained activation . Positive_regulation TNF JUN 11918684 894992 APC directly *inhibits* the production of [TNF-alpha] by inhibiting the activation of both nudear factor kappaB (NFkappaB) and in monocytes stimulated with LPS . Positive_regulation TNF JUN 12162440 971986 Oxidative stress and [TNF-alpha] *induce* histone acetylation and activation in alveolar epithelial cells : potential mechanism in gene transcription in lung inflammation . Positive_regulation TNF JUN 12168567 973640 [Tumour necrosis factor-alpha (TNF-alpha)] or endotoxin *induce* the activation of two major transcription factors , NF-kappa B ( nuclear factor-kappaB ) and ( activating protein-1 ) , which in turn induce genes involved in chronic and acute inflammatory responses . Positive_regulation TNF JUN 12195699 981734 Activated protein C *inhibits* lipopolysaccharide induced [tumor necrosis factor-alpha] production by inhibiting activation of both nuclear factor-kappa B and in human monocytes . Positive_regulation TNF JUN 12195699 981748 These observations strongly suggest that APC *inhibited* LPS induced [TNF-alpha] production by inhibiting the activation of both NF-kappa B and and that the inhibitory activity of APC might depend on its serine protease activity . Positive_regulation TNF JUN 12206715 1018749 EGCG as well as VP16 and [TNF] *induced* activation of two apoptosis regulating mitogen activated protein ( MAP ) kinases , namely and p38 MAP kinase , in both human leukaemic U937 and OCI-AML1a cells . Positive_regulation TNF JUN 12230306 988233 Methamphetamine induced [TNF-alpha] gene expression and *activation* of in discrete regions of mouse brain : potential role of reactive oxygen intermediates and lipid peroxidation . Positive_regulation TNF JUN 12361763 995016 [TNF] alone can *induce* MCMV IE-1 gene expression and activation of NFkappaB and in some tissues . Positive_regulation TNF JUN 12631113 1067646 The present data indicate that [TNF-alpha] *activation* of PKCzeta/iota , p42/44 MAPK , , and p65/NF-kappaB are involved in TNF-alpha stimulated MC fractalkine expression , with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro . Positive_regulation TNF JUN 12649382 1070546 Gabexate mesilate , a synthetic protease inhibitor , *inhibits* lipopolysaccharide induced [tumor necrosis factor-alpha] production by inhibiting activation of both nuclear factor-kappaB and in human monocytes . Positive_regulation TNF JUN 12649382 1070547 These observations strongly suggest that gabexate mesilate *inhibited* LPS induced [TNF-alpha] production in human monocytes by inhibiting activation of both NF-kappaB and . Positive_regulation TNF JUN 12746218 1088660 The effects of sauchinone on the inducible nitric oxide synthase (iNOS) , [tumor necrosis factor-alpha (TNF-alpha)] and cyclooxygenase 2 (COX-2) gene expression and on the *activation* of transcription factors , nuclear factor-kappaB (NF-kappaB) , CCAAT/enhancer binding protein (C/EBP) , and cAMP-response element binding protein ( CREB ) were determined in Raw264.7 cells as part of the studies on its anti-inflammatory effects . Positive_regulation TNF JUN 12874341 1115071 Activation of NF-kappa B and by P. aeruginosa GLP may be *involved* not only in [TNF-alpha] induction but also in many of the inflammatory responses triggered in the course of infection with P. aeruginosa . Positive_regulation TNF JUN 1331059 200230 Moreover , gel retardation analyses revealed that [TNF alpha] and IFN gamma synergistically *induced* the binding of NF-kB like as well as like proteins bound to these sites . Positive_regulation TNF JUN 14512437 1185701 [TNFalpha] *induced* a 3-fold increased activity of 1 in d PC12 cells within 20 min that could be increased 5- to 8-fold by P together with TNFalpha . Positive_regulation TNF JUN 14519430 1147714 With ANGII , binding of to the CRE site was *required* for [TNF-alpha] gene induction ; Positive_regulation TNF JUN 14617571 1209939 In conclusion , the above results demonstrate that [TNF] increased c-Jun by activating stress activated protein kinase/c-Jun-NH ( 2 ) -teminal kinase signaling via TNFR1 in mouse granulosa cells , and the induced *resulted* in increased cell proliferation . Positive_regulation TNF JUN 14736953 1199593 We investigated the *role* of NF-kappa B and in [tumour necrosis factor alpha (TNF-alpha)] induced monocyte chemoattractant protein 1 ( MCP-1 ) production in cultured human glomerular endothelial cells ( HGEC ) . Positive_regulation TNF JUN 14736953 1199602 On the other hand , dexamethasone decreased [TNF-alpha] *induced* DNA binding activity of without an effect on the DNA binding activity of NF-kappa B , cytosolic I kappa B alpha degradation or p65 nuclear translocation . Positive_regulation TNF JUN 15041472 1224413 These findings suggest that the inhibition of the LPS induced production of NO and [TNF-alpha] by the 2'-hydroxychalcone derivatives is *due* to the inhibition of NF-kappaB and activations . Positive_regulation TNF JUN 15061350 1230539 APC *inhibited* ET-induced [TNF-alpha] production in human monocytes by inhibiting activation of nuclear factor K-B and in vitro . Positive_regulation TNF JUN 15149634 1248415 IL-1 and [TNF-alpha] *induced* egr-1 and all member expression , except fosB and junD . Positive_regulation TNF JUN 15158360 1250641 In combination with p65 and/or C/EBPdelta , TAM-67 also synergistically activated the IL-6 promoter , while it inhibited [TNF-alpha] *induced* activity directing an AP-1-responsive reporter plasmid . Positive_regulation TNF JUN 15313439 1285536 In view of the potential *role* of in the induction of [TNF-alpha] , we next examined the inhibitory effects of arctigenin on the expression of TNF-alpha . Positive_regulation TNF JUN 15320513 1286520 APC *inhibits* ET-induced [TNF-alpha] production in vitro in human monocytes by inhibiting activation of NFkappaB and by inhibiting degradation of IkappaB and mitogen activated protein kinase pathways , respectively . Positive_regulation TNF JUN 15586558 1345875 Macrolides *inhibit* the production of many proinflammatory cytokines , such as interleukin (IL)-1 , IL-6 , IL-8 , and [tumor necrosis factor-alpha] , perhaps by suppressing the transcription factor nuclear factor-kappaB or . Positive_regulation TNF JUN 15681165 1370421 The results suggest that suppression of [TNF-alpha] expression by EPA may be partly *mediated* by its inhibitory effect on activation . Positive_regulation TNF JUN 16011481 1459391 [TNFalpha] *induces* NF-kappaB ( nuclear factor kappaB ) and ( activator protein 1 ) nuclear binding activities . Positive_regulation TNF JUN 16269458 1509285 On the other hand , [TNFalpha] and IL-1beta *induced* p38 , , and nuclear factor (NF)kappaB activation , pathways more closely related to stress response . Positive_regulation TNF JUN 16420740 1514802 In contrast , the broad-spectrum tyrosine kinase inhibitor genistein and the MEK-1 inhibitor ( PD98059 ) abrogated GM-CSF priming of [TNF-alpha] release and *activation* of both NF-kappaB and . Positive_regulation TNF JUN 16881863 1594530 Here , we report that activation of during dsRNA treatment or respiratory syncytial viral ( RSV ) infection negatively *regulates* the induction of [TNF-alpha] in human epithelial cells . Positive_regulation TNF JUN 17322278 1747576 [TNF-alpha] *induced* CD38 expression in human airway smooth muscle cells : role of MAP kinases and transcription factors NF-kappaB and . Positive_regulation TNF JUN 17424890 1723875 c-Fos and mRNAs were *induced* by [TNF-alpha] , and PD98059 ( MEK inhibitor ) and SB203580 ( p38 inhibitor ) abolished the up-regulation of c-Fos . Positive_regulation TNF JUN 17827742 1791586 cPrG . HCl inhibited neither [TNFalpha-] or PMA induced DNA binding of AP-1 nor co-activator p300 induced *activation* of . Positive_regulation TNF JUN 1827793 158504 These results suggest that the [TNF-responsive] element is not *activated* by or CREB in U937 cells and that a novel DNA binding factor is important for constitutive and inducible TNF gene expression . Positive_regulation TNF JUN 18302884 1873513 To study the *role* of in the up-regulation expression of [tumor necrosis factor-alpha (TNF-alpha)] and transforming growth factor-beta1 ( TGF-beta(1) ) in silica stimulated macrophage cells ( RAW264.7 ) . Positive_regulation TNF JUN 18577375 1935103 Our study demonstrate that ( 1 ) 6S functions as a PPARgamma agonist with its inhibitory mechanism due to the PPARgamma transactivation , and ( 2 ) 6G is not a PPARgamma agonist , but it is an effective inhibitor of [TNF-alpha] *induced* ( 2 ) -terminal kinase signaling activation and thus , its inhibitory mechanism is due to this inhibitory effect . Positive_regulation TNF JUN 18599158 2208591 and ( 3 ) S100B/RAGE induced upregulation of COX-2 , IL-1beta and [TNF-alpha] expression *requires* the concurrent activation of NF-kappaB and . Positive_regulation TNF JUN 19026990 2022783 The *activation* of by [TNF-alpha] was inhibited by myricetin in a dose dependent manner . Positive_regulation TNF JUN 19043087 2035343 The aim of this study was to investigate the *role* of signalling in cardiomyocyte [TNF-alpha] expression during lipopolysaccharide (LPS) stimulation and myocardial function in endotoxaemic mice . Positive_regulation TNF JUN 19235541 2079545 Exposure to cigarette smoke upregulates activity and *induces* [TNF-alpha] overexpression in mouse lungs . Positive_regulation TNF JUN 19628795 2137875 When NF-kappaB was inhibited after neonatal cerebral HI , activity was increased and *required* for increased [TNF-alpha] expression . Positive_regulation TNF JUN 19838780 2216989 In the present study , production of [TNF-alpha] and MIP-2 and *activation* of extracellular signal regulated kinases ( ERK ) 1/2 , and p38 in RAW264.7 cells were measured . Positive_regulation TNF JUN 20141610 2178969 [TNF-alpha] *induced* increased levels of and C-Fos in the nucleus accompanied by phosphorylation of c-Jun . Positive_regulation TNF JUN 20237583 2223928 Conversely , activation of negatively *regulates* [TNF-alpha] production through inhibition of ERK1/2 and p38 MAPK activity . Positive_regulation TNF JUN 20299740 2224053 Strategies that neutralize [TNF-alpha] as well as inhibitors of MAPK-NF-kappa B- and/or *dependent* pathways may be useful for suppressing the MMP-9 effect and thus preventing multiple organ failure in severe influenza . Positive_regulation TNF JUN 21136335 2355904 We determined the effect of DMF on platelet derived growth factor (PDGF)-BB induced proliferation , as well as on PDGF-BB and [tumor necrosis factor (TNF)-a] induced interleukin (IL)-6 secretion and on *activation* of and nuclear factor kappaB ( NF-?B ) . Positive_regulation TNF JUN 22021612 2507975 Hck kinase *mediates* TLR4 induced transcription of both [TNF] and IL-6 by a mechanism that involves neither the NF-?B nor the MAPK pathways , but rather leads to binding with a complex of c-fos and JunD . Positive_regulation TNF JUN 22198289 2558674 In addition , IL-1ß and [TNF-a/CHX] *induced* the phosphorylation of activating transcription factor-2 ( ATF-2 ) , but not . Positive_regulation TNF JUN 22343222 2617755 Using immunohistological techniques , we showed a higher epithelial expression of [TNF-a] , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activated protein kinase signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation TNF JUN 22385244 2566467 The use of selective inhibitors of signalling pathways revealed that induction of TG2 by IFN-? was mediated by phosphoinositide 3-kinase (PI3K) , while and p38 mitogen activated protein kinase (MAPK) were *required* for [TNF-a] activation . Positive_regulation TNF JUN 23791757 2820470 In the mechanism of LGC , while extracellular signal regulated kinase ( ERK ) was important for the induction of TNF-a , IL-1ß and IL-8 , the phosphorylation of *contributed* to the induction of [TNF-a] and IL-1ß to a greater degree . Positive_regulation TNF JUN 24587316 2920289 [TNF-a] *induced* also an increase in DNA binding activity and the antiapoptotic effect of TNF-a was potentiated by inhibitors of AP-1 , SR 11302 and tanshinone IIA and by an inhibitor of c-jun-N-terminal kinase , SP600125 , which is an upstream kinase activating AP-1 . Positive_regulation TNF JUN 7635431 317119 Using primary cultures of rat Kupffer cells the *role* of NF-kappa B and in the expression of the [tumor necrosis factor-alpha (TNF-alpha)] gene by lipopolysaccharide (LPS) was investigated . Positive_regulation TNF JUN 8552071 347101 [Tumor necrosis factor] alpha gene regulation in activated T cells *involves* and NFATp . Positive_regulation TNF JUN 9006914 410766 [TNFalpha] stimulation of endothelial cells *induces* transient phosphorylation of both ATF-2 and and induces marked activation of the c-JUN N-terminal kinase ( JNK1 ) and p38 but not extracellular signal regulated kinase ( ERK1 ) . Positive_regulation TNF JUN 9130478 426877 Nuclear factor of activated T cells ( NF-AT ) and transcription factors together *mediate* the activation of [TNF alpha] transcription in mast cells upon IgE plus antigen stimulation which , in contrast to the degranulation reaction and leukotriene synthesis , is independent of phosphoinositol-3-kinase . Positive_regulation TNF JUN 9317150 456268 In human endothelial cells , [TNF] rapidly *induces* N-terminal domain phosphorylation of both and ATF2 . Positive_regulation TNF JUN 9368689 463888 Cyclic AMP alone induced AP-1-responsive reporter ( p3TPLUX ) activity threefold after 2 h with peak effect of 4-fold at 4 hr . AP-1 reporter was not induced by [TNF alpha] alone but in the presence of cAMP , TNF alpha *induced* reporter activity 12-fold . Positive_regulation TNF JUN 9439980 475069 IL1 alpha and [TNF-alpha] rapidly *induced* both and NF-kB DNA binding activities in +/+ ( - ) 1.LDA11 stromal cells . Positive_regulation TNF JUN 9693360 523368 In addition , [tumor necrosis factor] alpha *activation* of was also much more robust in anchored cells . Positive_regulation TNF JUN 9830008 551246 H2O2 and [tumor necrosis factor-alpha] *induce* differential binding of the redox-responsive transcription factors and NF-kappaB to the interleukin-8 promoter in endothelial and epithelial cells . Positive_regulation TNF JUN 9830008 551278 Supershift analysis revealed H2O2 as well as [TNFalpha] *induced* complexes containing c-Fos and JunD . Positive_regulation TNF JUNB 10858536 730026 Whilst the expression of JunD was not affected by any of the mediators , the mRNA levels of c-fos and were *induced* by LPS , IL-6 , IFN-gamma , PDGF and [TNF-alpha] , and that of c-jun by LPS , IFN-gamma , PDGF and TNF-alpha . Positive_regulation TNF KARS 15851690 1404032 Among them , we found that ( KRS ) was secreted from intact human cells , and its secretion was *induced* by [TNF-alpha] . Positive_regulation TNF KCNMA1 16110172 1498944 This chapter provides protocols to measure the reversible permeabilization of mast cells by streptolysin O (SLO) and to follow *induced* activation of mast cells by monitoring degranulation , activation of mitogen activated protein kinases , and production of [tumor necrosis factor-alpha] . Positive_regulation TNF KCNMA1 19074007 2030415 Although inhibitors *suppressed* endotoxin mediated [tumor necrosis factor-alpha] secretion by bone marrow derived macrophages ( BMDMs ) , BMDMs of BK ( -/- ) and wild-type mice responded identically and exhibited the same ERK , PI3K/Akt , and nuclear factor-kappaB activation . Positive_regulation TNF KCNMA1 19074007 2030416 Based on these data , we conclude that the is not *required* for NADPH oxidase activity in PMNs or macrophages or for endotoxin triggered [tumor necrosis factor-alpha] release and signal transduction BMDMs . Positive_regulation TNF KCTD10 15982757 1428462 Like PDIP1 , the expression of gene can be *induced* by [TNF-alpha] in NIH3T3 cells . Positive_regulation TNF KDR 14532277 1174888 Furthermore , [TNF-] but not VEGF induced *activation* of , Akt , and EC migration are blunted in EC genetically deficient with Etk . Positive_regulation TNF KDR 22499991 2595584 In mice with diabetes mellitus , excessive [tumor necrosis factor-a] *induced* miR-200b blunting proangiogenic functions of GATA2 and . Positive_regulation TNF KHDRBS1 21620750 2454480 is *required* for both NF-?B activation and apoptosis signaling by the [TNF] receptor . Positive_regulation TNF KHSRP 8145037 252603 A number of recent studies have demonstrated that cellular responses to [tumor necrosis factor (TNF)] *mediated* by the p55 and the TNF receptors are distinct . Positive_regulation TNF KHSRP 9551933 499116 We have examined the *roles* of p55 and in mediating and modulating the activity of [TNF] in vivo by generating and examining mice genetically deficient in these receptors . Positive_regulation TNF KHSRP 9551933 499121 In summary , these data help clarify the biologic *roles* of p55 and in mediating and modulating the biologic activity of [TNF] and provide genetic evidence for an antagonistic role of p75 in vivo . Positive_regulation TNF KIR3DL1 16114098 1454327 The engagement of CD8 or activating also *triggered* the production of [TNF-alpha] . Positive_regulation TNF KISS1R 19201817 2061383 Activation of *resulted* in the ERK dependent expression of [tumor necrosis factor-alpha] and FasL in a lymphoid cell line , the latter being the main trigger of apoptosis . Positive_regulation TNF KITLG 10889302 710423 *enhances* IgE mediated histamine and [TNF-alpha] release from dispersed canine cutaneous mast cells . Positive_regulation TNF KLF4 21166929 2385270 MEK5 is activated by shear stress , activates ERK5 and *induces* to modulate [TNF] responses in human dermal microvascular endothelial cells . Positive_regulation TNF KLK3 17988090 1831324 Furthermore , *increased* [TNF-alpha] and IFN-gamma levels in mice when compared with those of untreated mice . Positive_regulation TNF KLK3 23323011 2712638 could *increase* IL-1a , IL-2 , IL-6 , and [TNF-a] expression and decrease IL-10 levels . Positive_regulation TNF KLRC1 16081780 1442830 Furthermore , *triggers* the production of [TNF-alpha] but not of IFN-gamma , as well as the release of cytolytic granules by Vgamma9 Vdelta2 T cells . Positive_regulation TNF KLRC1 21600899 2449966 Costimulation of and the T-cell receptor ( TCR ) significantly *increased* production of IL-17 and [tumor necrosis factor] a by CD4+ T cells , compared with activation of only the TCR . Positive_regulation TNF KLRD1 11069065 747681 By the use of the MEK inhibitor PD098059 we demonstrate that the MAPK pathway participates in the *dependent* [TNF-alpha] production and cytotoxicity . Positive_regulation TNF KLRD1 8104219 229038 It is noteworthy that the *mediated* production of [TNF-alpha] was partially inhibited by anti-CD18 , anti-CD11a and anti-ICAM-1 mAb that blocked LFA-1 dependent cellular interactions , which impaired NK cell aggregation and , moreover , was dependent on the presence of extracellular Mg2+ , thus suggesting that the leukocyte integrin is involved in the activation process triggered through Kp43 . Positive_regulation TNF KLRD1 9310830 454992 In addition , cross linking of p40 molecules strongly inhibited the *induced* [tumor necrosis factor-alpha] and IFN-gamma production . Positive_regulation TNF KLRG1 22891217 2687638 In addition , also *attenuated* the accumulation of ß-catenin and overexpression of vascular endothelial growth factor , intercellular adhesion molecule-1 , and [tumor necrosis factor-a] induced by high-glucose medium in retinal endothelial cells . Positive_regulation TNF KMT2A 12445799 1017644 Upon *stimulation* with , monocytes produced [TNF-alpha] and Interleukin-12 (IL-12) , which play a role in the innate immune response to infection . Positive_regulation TNF KRAS 17059425 1683921 Zoledronate reduced Ras prenylation , and RhoA translocation to the membrane , and sustained ERK1/2 phosphorylation and [tumor necrosis factor (TNF)] *induced* JNK phosphorylation . Positive_regulation TNF KRAS 17994109 1851138 [TNF-alpha] triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* , p38 MAPK , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation TNF KRR1 17588511 1764384 In a recent issue of Molecular Cell , Kim et al. ( 2007 ) reported on a novel [TNF] receptor 1 necrotic signaling complex *inducing* TRADD- and dependent recruitment and activation of the ROS generating Nox1 NADPH oxidase complex . Positive_regulation TNF KRT14 9060638 417776 We now report that [TNF] induces translocation of cPLA2 from the cytosol to membranes in Ad-infected human A549 cells and that but not E3-14.7K or E1B-19K is *required* to inhibit TNF induced translocation of cPLA2 . Positive_regulation TNF KRT6B 10887174 736711 Specifically , [TNFalpha] *induces* the transcription of the gene promoter . Positive_regulation TNF KSR1 11221891 787426 is *necessary* for [tumor necrosis factor] alpha activation of extracellular signal regulated kinase/mitogen activated protein kinase in intestinal epithelial cells . Positive_regulation TNF KSR1 11751383 889872 Our laboratory reported that *regulates* [TNF] activation of the Raf/mitogen activated protein (MAP) kinase/extracellular signal regulated kinase ( ERK ) kinase/ERK signaling cassette by threonine phosphorylation of Raf-1 , regulating proliferation and differentiation pathways . Positive_regulation TNF KSR1 11751383 889875 However , [TNF] activation of p38 or stress activated protein kinase/c-Jun NH ( 2 ) -terminal kinase is not *inhibited* by disruption of signaling . Positive_regulation TNF LAMA1 18434122 1926365 IL-1beta or [TNF-alpha] alone *induced* increased secretion of type IV collagen , , and nidogen-1/entactin , all of which contributed to this upregulation . Positive_regulation TNF LAMB1 18434122 1926366 IL-1beta or [TNF-alpha] alone *induced* increased secretion of type IV collagen , , and nidogen-1/entactin , all of which contributed to this upregulation . Positive_regulation TNF LAMB1 21940676 2497477 Interestingly , selectively *promoted* production of [TNF-a] and IL-6 in macrophages triggered by TLR9 , but not TLR4 or TLR3 . Positive_regulation TNF LAMC1 18434122 1926367 IL-1beta or [TNF-alpha] alone *induced* increased secretion of type IV collagen , , and nidogen-1/entactin , all of which contributed to this upregulation . Positive_regulation TNF LAMP1 24068451 2920989 CD14 was involved in *stimulated* production of [tumor necrosis factor (TNF)-a] by blocking CD14 antibody in THP-1 cells . Positive_regulation TNF LAMP1 24068451 2920994 Co-transfection experiments in HeLa cells provide evidence that CD14 facilitates *induced* [TNF-a] release via toll-like receptor 2 (TLR2) . Positive_regulation TNF LAMP1 24068451 2920999 In addition , *induced* [TNF-a] release was increased by soluble CD14 but decreased by soluble TLR2 . Positive_regulation TNF LAMP2 24068451 2920990 CD14 was involved in *stimulated* production of [tumor necrosis factor (TNF)-a] by blocking CD14 antibody in THP-1 cells . Positive_regulation TNF LAMP2 24068451 2920995 Co-transfection experiments in HeLa cells provide evidence that CD14 facilitates *induced* [TNF-a] release via toll-like receptor 2 (TLR2) . Positive_regulation TNF LAMP2 24068451 2921000 In addition , *induced* [TNF-a] release was increased by soluble CD14 but decreased by soluble TLR2 . Positive_regulation TNF LAMP3 24068451 2920986 CD14 was involved in *stimulated* production of [tumor necrosis factor (TNF)-a] by blocking CD14 antibody in THP-1 cells . Positive_regulation TNF LAMP3 24068451 2920992 Co-transfection experiments in HeLa cells provide evidence that CD14 facilitates *induced* [TNF-a] release via toll-like receptor 2 (TLR2) . Positive_regulation TNF LAMP3 24068451 2920996 In addition , *induced* [TNF-a] release was increased by soluble CD14 but decreased by soluble TLR2 . Positive_regulation TNF LAMP5 24068451 2920987 CD14 was involved in *stimulated* production of [tumor necrosis factor (TNF)-a] by blocking CD14 antibody in THP-1 cells . Positive_regulation TNF LAMP5 24068451 2920993 Co-transfection experiments in HeLa cells provide evidence that CD14 facilitates *induced* [TNF-a] release via toll-like receptor 2 (TLR2) . Positive_regulation TNF LAMP5 24068451 2920997 In addition , *induced* [TNF-a] release was increased by soluble CD14 but decreased by soluble TLR2 . Positive_regulation TNF LANCL1 12871593 1114117 *Induction* of [tumor necrosis factor-alpha (TNF-alpha)] by interleukin-12 monomer and homodimer in microglia and macrophages . Positive_regulation TNF LANCL1 12871593 1114119 The present study was undertaken to explore the *role* of interleukin-12 (IL-12) in the expression of [TNF-alpha] in microglia . Positive_regulation TNF LANCL1 12871593 1114122 Interestingly , we have found that IL-12 p70 , p402 ( the p40 homodimer ) and ( the p40 monomer ) dose-dependently *induced* the production of [TNF-alpha] and the expression of TNF-alpha mRNA in BV-2 microglial cells . Positive_regulation TNF LANCL1 19088276 2018617 We detected expression of interleukin (IL)-6 , [tumour necrosis factor (TNF)-alpha] , macrophage inflammatory protein (MIP)-1alpha , MIP-1beta , RANTES and IL-12p40 from 2 to 6 h post-infection , and these peaked by 15-24 h. Expression of these factors decreased 24-48 h post-infection , with the exception of TNF-alpha which remained high throughout the entire 72 h. Interestingly , while expression *increased* post-infection , bioactive IL-12p70 was not detected in the supernatants . Positive_regulation TNF LBH 24278143 2876867 In co-culture experiments of lymphocytes with HL cells , suppressed the IFNgamma-release but *increased* the [TNFalpha] secretion . Positive_regulation TNF LBP 11828371 909624 *enhanced* [TNF-alpha] release of human peripheral blood mononuclear cells ( PBMC ) upon LPS but not LTA stimulation . Positive_regulation TNF LBP 12181178 977488 With increasing concentrations of LPS , human Kupffer cell [tumor necrosis factor-alpha (TNF-alpha)] production ( a marker for Kupffer cell activation ) increased in a dose dependent manner in the *presence* and absence of . Positive_regulation TNF LBP 12198381 982191 Serum *enhances* the secretion of [TNF-alpha] by macrophages . Positive_regulation TNF LBP 1281827 205734 Thus , immunoreactive accumulates in lung lavage fluids in patients with lung injury and *enhances* LPS stimulated [TNF alpha] gene expression in alveolar macrophages by a pathway that depends on the CD14 receptor . Positive_regulation TNF LBP 12932360 1132536 *enhanced* PCW induced cell signaling and [TNF-alpha] release . Positive_regulation TNF LBP 1607653 189302 However , consistent with our previous observations that these structures bind to LBP , [TNF] production was increased in the *presence* of . Positive_regulation TNF LBP 1883513 165625 Compared to *induction* of [TNF-alpha] , LPS-lipoprotein complexes are as much as 10,000-fold less active . Positive_regulation TNF LBP 7520172 266269 This demonstrated that anti-LBP IgG could block the *mediated* [TNF] release upon LPS challenge . Positive_regulation TNF LBP 7526573 280434 *enhanced* the chitosan induced [TNF-alpha] production only to a minor degree , suggesting that serum proteins other than LBP play an important role in the stimulatory effect . Positive_regulation TNF LCN2 20068130 2225522 Cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate ( CDC ) , an arachidonate lipoxygenase inhibitor , prevents [TNF-alpha] expression *induced* by . Positive_regulation TNF LCN2 24440229 2922762 Furthermore , neutrophil infiltration , myeloperoxidase activity , expression of [TNF-a] , IL-1ß and MIP-2 in CFA injected hindpaws , and spinal glial activation were markedly *reduced* by deficiency . Positive_regulation TNF LDHA 14586559 1187182 In patients after administration of chemotherapy , [TNF-alpha] in a dose of 100 U/ml *induced* a significant increase ( p < 0.05 ) of isotype activity , but not of LDH-H . Positive_regulation TNF LDHB 14586559 1187183 In patients after administration of chemotherapy , [TNF-alpha] in a dose of 100 U/ml *induced* a significant increase ( p < 0.05 ) of LDH-M isotype activity , but not of . Positive_regulation TNF LDLR 9624172 511394 Similarly , [TNF] *induced* expression also required ERK-1/2 activation . Positive_regulation TNF LEO1 10422778 632390 However , exogenously added up to 100 nM did not *stimulate* production of [tumor necrosis factor-alpha] . Positive_regulation TNF LEO1 10435033 634213 [TNF-alpha] in the *presence* of WEB 2170 or CV 3988 , or was studied with the Greiss reagent method . Positive_regulation TNF LEO1 10921504 717356 antioxidants significantly inhibited both the in vivo and in vitro *induced* NF-kappaB activation and NF-kappaB dependent [TNF-alpha] expression . Positive_regulation TNF LEO1 15316260 1286194 The aim of this study was to determine [tumor necrosis factor alpha (TNF-alpha)] and interleukin-6 (IL-6) release in *response* to induction in peripheral blood mononuclear cells ( PBMCs ) from chronic hepatitis B virus ( HBV ) carriers . Positive_regulation TNF LEO1 15316260 1286214 Compared with group A , PBMCs from naturally immune subjects and chronic HBV carriers produced significantly higher amounts of [TNF-alpha] and IL-6 in *response* to . Positive_regulation TNF LEO1 15702351 1382762 Finally , up to 2 mug/ml , did not *induce* the production of pro-inflammatory cytokines such as IL-6 , IL-8 , and [TNF-alpha] . Positive_regulation TNF LEO1 1613396 191107 can *augment* [tumor necrosis factor (TNF)] production by human monocytes in a bimodal manner , with two peaks of activation at picomolar and micromolar concentrations . Positive_regulation TNF LEO1 1613396 191112 Moreover , 6 day- or 7 day differentiated HL-60 cells showed a further increase in [TNF] production in *response* to , and the response was bimodal , similar to that of the less dense subset of monocytes , with peaks at 10 ( -14 ) and 10 ( -7 ) M PAF . Positive_regulation TNF LEO1 1668105 176686 *induced* maximal [TNF alpha] synthesis 2-3 hr after monocyte stimulation as assessed by dot blotting of cell associated TNF alpha using polyclonal anti-TNF antibody . Positive_regulation TNF LEO1 16829183 1591448 Both [TNF-alpha] and IL-1beta induced HUVEC platelet activating factor (PAF) production and was *required* for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine ) . Positive_regulation TNF LEO1 17881124 1802341 The data indicate that these three biochemically unrelated classes of inflammatory repressors act synergistically in modulating *induced* up-regulation of COX-2 , [TNFalpha] , and PGE ( 2 ) by quenching oxidative stress or inflammatory signaling , resulting in increased HN cell survival . Positive_regulation TNF LEO1 1873355 165244 Further , the *role* of released in response to a challenge with LPS in the regulation of [TNF] and IL-6 production was investigated . Positive_regulation TNF LEO1 19769579 2258183 Our previous studies have demonstrated that UVB mediated production of keratinocyte [TNF-alpha] is in part *due* to . Positive_regulation TNF LEO1 20116443 2258833 An immediate low release of PGE ( 2 ) was *induced* by PAF , phorbol ester and arachidonic acid but not by IL1beta , [TNF-alpha] and LPS whereas a delayed high release of PGE ( 2 ) was induced by the inflammatory agents IL1beta , TNF-alpha and LPS but not by , phorbol ester and arachidonic acid . Positive_regulation TNF LEO1 20187806 2216117 However , did not *stimulate* the generation of IL-6 , IL-8 , [TNF-alpha] , and MMP-1 to any significant level and in a consistent manner . Positive_regulation TNF LEO1 20423922 2437235 In rats , [TNF-a] increased hydraulic conductivity 2.5-fold over baseline and *increased* it 5-fold ; Positive_regulation TNF LEO1 2133285 150727 Secretion of [TNF] was *detected* shortly after addition of and was dependent on the PAF concentration used . Positive_regulation TNF LEO1 2133285 150732 While biologically active and cytotoxic [TNF] was *detected* early after addition of , the cytotoxic activity declined thereafter though the antigenic activity remained constant . Positive_regulation TNF LEO1 2133286 150737 We have recently shown that can markedly *enhance* the production of [tumor necrosis factor (TNF)] and interleukin-1 (IL-1) by human monocytes stimulated with lipopolysaccharide or muramyl dipeptide ( MDP ) . Positive_regulation TNF LEO1 2230235 144611 The decrease in plasma [TNF alpha] *induced* by or alprazolam was partly reversed by indomethacin . Positive_regulation TNF LEO1 2266661 147298 Inhibitors of PAF synthesis , such as plasma alpha 1-proteinase inhibitor and an anti-inflammatory peptide , blocked changes induced by TNF , PAF receptor antagonists inhibited changes *induced* by and also by [TNF] . Positive_regulation TNF LEO1 2329280 132461 increased cell associated TNF maximally after 2 to 3 h of incubation and *increased* [TNF] release maximally after 5 to 18 h of incubation . Positive_regulation TNF LEO1 2545780 114298 *enhances* [tumor necrosis factor] production by alveolar macrophages . Positive_regulation TNF LEO1 2545780 114308 *Stimulation* of [TNF] production by was blocked by specific , but structurally different PAF receptor antagonists , BN 52021 , CV3988 and WEB 2086 . Positive_regulation TNF LEO1 2545780 114313 Inhibition of 5-lipoxygenase by nordihydro-guaiaretic acid or AA-861 blocked the *induced* augmentation of both [TNF] and LTB4 production . Positive_regulation TNF LEO1 2545780 114325 Collectively , these data suggest that *enhances* [TNF] production by interaction with a specific putative receptor and by subsequent induction of endogenous 5-lipoxygenase activity in AM . Positive_regulation TNF LEO1 7634340 317039 In addition , significantly *enhanced* LPS induced [TNF alpha] production . Positive_regulation TNF LEO1 7683748 216569 It has also been reported , that murine TNF stimulates the production of platelet activating factor (PAF) by cultured peritoneal macrophages , and that *enhances* [TNF] production by alveolar macrophages . Positive_regulation TNF LEO1 7821968 285551 We have shown previously that endotoxin , tumour necrosis factor (TNF) and platelet activating factor (PAF) are important in the pathogenesis of bowel injury , and that endotoxin and [TNF] *induce* formation in bowel tissue . Positive_regulation TNF LEO1 7895533 299760 also *caused* elevated serum [TNF-alpha] in some control mice but not in C3H/HeJ mice . Positive_regulation TNF LEO1 7930608 274732 Despite increasing RNA for the TNF-alpha gene , *increases* [TNF-alpha] protein levels only in the presence of a costimulus , such as PMA . Positive_regulation TNF LEO1 7930608 274737 We also report that *enhances* PMA induced [TNF-alpha] production from human peripheral B cells . Positive_regulation TNF LEO1 8045673 266908 ET-18-O-OCH3 and *stimulated* [TNF alpha] release by resident BALB/c macrophages in the presence of LPS but not in the absence of this co-factor . Positive_regulation TNF LEO1 8045673 266913 In contrast , both ET-18-O_OCH3 and *stimulated* [TNF alpha] release by thioglycollate elicited macrophages in the absence of LPS although release was greater in the presence of this co-stimulus . Positive_regulation TNF LEO1 8080039 270816 Interleukin-1 beta and [tumor necrosis factor-alpha] *induce* production by endothelium , and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist . Positive_regulation TNF LEO1 8088357 271462 Furthermore , [TNF] production *induced* by itself in vitro was also inhibited in the presence of FR128998 . Positive_regulation TNF LEO1 8514698 221954 Repeated dosing also *resulted* in sustained increased serum [tumor necrosis factor-alpha] levels ( 1,610 +/- 470 pg/ml , P < 0.01 ) and further exacerbation of the leukopenia ( -68 +/- 6 % , P < 0.01 ) and thrombocytopenia ( -65 +/- 8 % , P < 0.01 ) . Positive_regulation TNF LEO1 8704099 371133 We have assessed whether *stimulates* IL-6 and [TNF-alpha] production by human bone marrow stromal cells ( mostly fibroblast-like cells ) . Positive_regulation TNF LEO1 9249487 446831 and 2 ) endogenous [TNF-alpha] is not required for LPS mediated induction of iNOS mRNA , and *mediates* LPS induced APH . Positive_regulation TNF LEO1 9394802 468193 These data suggest that , which is released immediately or shortly after LPS injection , *induces* the expression of [TNF-alpha] through the activation of NF-kappa B . Positive_regulation TNF LEP 11960027 931512 *increased* [tumor necrosis factor (TNF)-alpha] release at a 100-fold lower dose than required for NO release in vitro and in vivo , suggesting that it also may participate in leptin induced NO release . Positive_regulation TNF LEP 11960027 931513 However , because many molecules of leptin were required to release a molecule of TNF-alpha in vivo and in vitro , we believe that *induced* [TNF-alpha] release is an associated phenomenon not involved in NO production . Positive_regulation TNF LEP 15114059 1241395 Our data showed that *induced* [tumor necrosis factor-alpha] , interleukin-6 , and interleukin-10 production by PBMCs of patients in an acute phase of disease but not in patients in a stable phase or in healthy controls . Positive_regulation TNF LEP 15905315 1426881 however , at 100 ng/ml and adiponectin at 0.1 and/or 0.5 microg/ml significantly *increased* the release of IL-1beta , IL-6 , [TNFalpha] , and PGE2 from human placenta and adipose tissue . Positive_regulation TNF LEP 15979653 1428396 *enhances* [TNF-alpha] production via p38 and JNK MAPK in LPS stimulated Kupffer cells . Positive_regulation TNF LEP 15979653 1428398 *enhanced* [TNF-alpha] production accompanied by a dose dependent increase of MAPK activity in lipopolysaccharide (LPS) stimulated KCs . Positive_regulation TNF LEP 16438946 1495421 Globular adiponectin decreases *induced* [tumor necrosis factor-alpha] expression by murine macrophages : involvement of cAMP-PKA and MAPK pathways . Positive_regulation TNF LEP 16438946 1495422 *stimulated* [TNF-alpha] production at mRNA as well as protein levels in a dose- and time dependent manner . Positive_regulation TNF LEP 16438946 1495442 gAd inhibited *induced* [TNF-alpha] production through suppressing phosphorylation of ERK1/2 and p38 pathways . Positive_regulation TNF LEP 17551224 1752633 treatment *augmented* the monocyte/macrophages mRNA expression of only [TNF-alpha] and IL-12p40 to comparable levels of cells treated with lipopolysaccharide (LPS) . Positive_regulation TNF LEP 19059800 2041886 Stimulation of PBMCs by exogenous significantly *increased* the production of IL-6 and [TNF-alpha] in PBMCs from patients with AS in a dose dependent fashion and these increases were much exacerbated compared to controls . Positive_regulation TNF LEP 19902102 2161760 increased the expression of HLA-DR on T lymphocytes , *stimulated* the production of [TNF-alpha] and IL-6 , and did not affect secretion of IL-2 , IL-4 , and IL-10 by mononuclear leukocytes . Positive_regulation TNF LEP 21229279 2419646 Plasma levels of [tumor necrosis factor-a (TNF-a)] , interleukin 8 (IL-8) , interferon-? inducible protein-10 (IP-10) , monocyte chemotactic protein-1 (MCP-1) , soluble urokinase-type plasminogen activator ( suPAR ) , monokine *induced* by ?-interferon ( MIG ) , human hepatocyte growth factor (HGF) , insulin , interleukin 6 (IL-6) , interleukin 1-ß (IL-1ß) , , and nerve growth factor (NGF) were analyzed . Positive_regulation TNF LEP 21524765 2449109 The IL-6 and [TNF alpha] levels were not modified in the MA group , but did *increase* ( p < 0.043 ) . Positive_regulation TNF LEP 21840575 2584900 In addition , *enhanced* both [TNF-a] mRNA synthesis and secretion from MCF7 . Positive_regulation TNF LEP 9388486 466951 When considered in the context of animal studies showing that interleukin-1 and [tumor necrosis factor-alpha] *induce* and ob mRNA , these results suggest that pro-inflammatory cytokines induce ob gene transcription in vivo via secondary mediators such as transforming growth factor-beta . Positive_regulation TNF LEP 9564834 500796 To determine whether [TNF alpha] *induces* secretion by acting directly on fat cells , primary adipocytes from OuJ and HeJ mice were cultured in the presence of TNF alpha or LPS . Positive_regulation TNF LEP 9874578 583579 Since [TNF] also *induces* , a hormone secreted by adipocytes that modulates food intake and metabolism , we questioned the role of leptin in TNF induced pathology . Positive_regulation TNF LGALS3 17259811 1696701 expression was *induced* by [tumor necrosis factor-alpha (TNF-alpha)] and interferon (IFN)-gamma in a monocytic cell line U937 . Positive_regulation TNF LGALS3 17259811 1696705 also *induced* mRNA expression and protein production of [TNF-alpha] and interleukin (IL)-8 in a macrophage cell line THP-1 . Positive_regulation TNF LGALS3 21924517 2524966 Toxoplasma gondii glycosylphosphatidylinositols ( GPIs ) bind to to *induce* [TNF-a] production in macrophages via Toll-like receptors 2 and 4 . Positive_regulation TNF LGALS4 18612433 1935898 Providing further evidence for its important role in regulating T cell function , blockade by antisense oligonucleotides *reduced* [TNF-alpha] inhibitor induced T cell death . Positive_regulation TNF LGALS9 22186414 2543391 In contrast , *induced* [TNF-a] production in cultured DC in a dose dependent manner ; Positive_regulation TNF LGALS9 22186414 2543392 however , RMT3-23 inhibited *induced* [TNF-a] production in a dose dependent manner . Positive_regulation TNF LGALS9 23836896 2829274 Furthermore , specific knockdown of c-Jun via siRNA in astrocytes before TNF treatment greatly suppressed Gal-9 transcription , suggesting that [TNF] *induces* astroglial through the TNF/TNFR1/JNK/cJun signaling pathway . Positive_regulation TNF LIF 18552402 1945961 Expression of IL-6 and was *induced* by [TNFalpha] in wild-type and JNK2-null myoblasts . Positive_regulation TNF LIF 8592105 341983 Furthermore , TNF-alpha induced LIF mRNA is blocked by the IL-1 receptor antagonist , whereas IL-1 induced LIF mRNA is not affected by TNF-alpha antibodies , suggesting that [TNF-alpha] first induces IL-1 , and IL-1 subsequently *induces* . Positive_regulation TNF LILRA2 17202177 1724679 Cross linking of on macrophages *caused* substantial production of tumour necrosis factor ( [TNF-alpha] ) in a dose- and time dependent manner that was strongly inhibited by dexamethasone . Positive_regulation TNF LIPA 11488917 845274 The interaction of hemoglobin ( Hb ) with endotoxins [ i.e. with enterobacterial deep rough mutant lipopolysaccharide (LPS) Re and the `` endotoxic principle '' of LPS , lipid A ] was investigated using a variety of physical techniques and with two biological assays , [tumor necrosis factor (TNF)-alpha] *induction* in human mononuclear cells and the assay . Positive_regulation TNF LIPA 7548538 323163 Biological activity ( endotoxicity ) was assessed by the assay , *induction* of [tumor necrosis factor (TNF)] from human mononuclear leukocytes , and a lethality model with galactosamine sensitized mice . Positive_regulation TNF LIPE 20096374 2248384 Moreover , *increased* nitric oxide ( NO ) and [Tumor Nuclear Factor-alpha (TNF-alpha)] and decreased Transforming Growth Factor-beta ( TGF-beta ) production in macrophages . Positive_regulation TNF LITAF 10200294 605497 Inhibition of mRNA expression in THP-1 cells *resulted* in a reduction of [TNF-alpha] transcripts . Positive_regulation TNF LITAF 15025820 1222452 Taken together , these results highlight the important *role* of in the regulation of [TNF-alpha] gene expression and suggest a potential role of LITAF in mouse organogenesis . Positive_regulation TNF LITAF 16804395 1579568 These data provide strong evidence of a *role* for in the pathophysiological regulation of the [TNF-alpha] gene and underscore the potential value of anti-LITAF strategies in the clinical management of these diseases . Positive_regulation TNF LITAF 18554501 1929372 Lipopolysaccharide induced TNF-alpha factor ( ) , a transcription factor , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Positive_regulation TNF LITAF 21663590 2464777 In our previous study , we have shown that a transcription factor LPS induced TNF factor ( ) significantly *induces* [TNF-a] production . Positive_regulation TNF LITAF 21984950 2493370 This study provides evidence that *contributes* to the regulation of [TNF-a] in LPM harvested following acute inflammation or LPS treatment paving the way for future work focusing on LITAF inhibitors in the treatment of TNF-a mediated inflammatory conditions . Positive_regulation TNF LITAF 23795761 2828639 Gain- and loss-of-function experiments in different B-cell lymphoma cell lines revealed that , in contrast to its function in monocytes , does not *induce* lipopolysaccharide mediated [TNF] secretion in B cells . Positive_regulation TNF LMO7 15383598 1298960 Lipidated ( L ) -Omp16 and , but not their unlipidated forms , *induced* the secretion of [TNF-alpha] , IL-6 , IL-10 , and IL-12 in a time- and dose dependent fashion . Positive_regulation TNF LMO7 23587438 2778594 A concomitant abrogation of B. abortus- and *induced* [TNF-a] production was observed when p38 and Erk1/2 pathways were inhibited , indicating that TNF-a could be implicated in MMP-9 secretion . Positive_regulation TNF LNPEP 8260704 238865 In addition , *had* little effect on the production of either IL-2 or [tumor necrosis factor] . Positive_regulation TNF LOX 18174253 1875689 The expression of was significantly higher in JB6 P+ cells than in JB6 P- cells that were resistant to transformation , and its expression was further *increased* by [tumor necrosis factor (TNF)-alpha] . Positive_regulation TNF LOX 18174253 1875691 These results indicate that is *induced* by the inflammatory cytokine [TNF-alpha] in the early stage of tumorigenesis , and is required for tumor promotion through enhancing efficient proliferation of a small number of initiated cells . Positive_regulation TNF LOX 21893029 2486940 [TNF-a] *increases* cardiac fibroblast expression through TGF-ß and PI3Kinase signaling pathways . Positive_regulation TNF LPA 10394297 627354 They show that with a panel of macrophage-like cell lines of varying maturation ( P388D , THP-1 , U937 , HL-60 ) , the ability to produce TNF alpha spontaneously and to synthesize [TNF alpha] in *response* to atherogenic low-density stimulation correlates with the degree of cell differentiation that can be in turn induced by agents such as phorbol myristic acetate . Positive_regulation TNF LPA 10559223 566460 Importantly , a TLR2 antibody inhibited bacterial *induced* [tumor necrosis factor] release from human peripheral blood mononuclear cells , and TLR2-null Chinese hamster macrophages were insensitive to lipoprotein/lipopeptide challenge . Positive_regulation TNF LPA 10657578 664020 In contrast , the study suggests that very-low-density ( VLDL ) in hypertriglyceridemic patients *augments* [TNF-alpha] production . Positive_regulation TNF LPA 11890657 894238 LPS , the mycobacterial glycolipids , and the OspC ( a TLR2 agonist ) all *induced* macrophages to secrete [tumour necrosis factor alpha (TNFalpha)] , whereas only LPS could induce nitric oxide ( NO ) secretion . Positive_regulation TNF LPA 12972290 1139479 Purified *led* to an increased secretion of IL-6 , but not [TNF-alpha] arguing against a general activation of these cells . Positive_regulation TNF LPA 15893422 1419724 Lipoproteins are the key inflammatory molecule type of Borrelia burgdorferi , the spirochete that causes Lyme disease , and we had previously shown that *induced* [TNF-alpha] production in astrocytes caused astrocyte apoptosis , and IL-6 enhanced proliferation of these cells . Positive_regulation TNF LPA 19154986 2027109 The Mtb 19 kDa *induced* release of [tumor necrosis factor] in a manner dependent on both TLR2 and RP105 , and macrophage activation by Mtb lacking mature lipoproteins was not RP105 dependent . Positive_regulation TNF LPA 19302817 2064270 Using the AhR antagonist alpha-napthtoflavone , the translational inhibitor cycloheximide and anti-tumor necrosis factor alpha (TNFalpha) neutralizing antibodies , we demonstrated that mediated mRNA induction of CCL1 occurs in an AhR independent manner and *requires* de novo protein synthesis of [TNFalpha] . Positive_regulation TNF LPA 22493518 2595542 ATX expression from SFs was induced by [TNF] , and *induced* SF activation and effector functions in synergy with TNF . Positive_regulation TNF LPA 23158405 2780452 The 20 : 4 selectively *stimulated* LPA receptor and [tumor necrosis factor] a expression in Hep3B cells , whereas 18 : 2 LPA did not . Positive_regulation TNF LPA 9578494 503260 Involvement of calcium and arachidonate metabolism in *stimulated* [tumor-necrosis-factor-alpha] production by rat peritoneal macrophages . Positive_regulation TNF LPCAT2 22290395 2617477 Furthermore , [tumor necrosis factor-a] and transforming growth factor-ß1 *induced* the expression of and Abcc1/4 and down-regulated Slc10a1 and Slco1a1 in primary hepatocytes , suggesting an association between the changes in serum LPC and bile acids and proinflammatory cytokines . Positive_regulation TNF LPCAT4 22290395 2617478 Furthermore , [tumor necrosis factor-a] and transforming growth factor-ß1 *induced* the expression of and Abcc1/4 and down-regulated Slc10a1 and Slco1a1 in primary hepatocytes , suggesting an association between the changes in serum LPC and bile acids and proinflammatory cytokines . Positive_regulation TNF LPL 10364070 620310 Differentiation of human monocytes to monocyte derived macrophages is associated with increased *induced* [tumor necrosis factor-alpha] expression and production : a process involving cell surface proteoglycans and protein kinase C . Positive_regulation TNF LPL 10364070 620311 Although heparinase totally abolished *induced* [TNFalpha] production in human monocytes , this agent did not significantly inhibit LPL effect in human MDMs . Positive_regulation TNF LPL 10364070 620312 In contrast , treatment of MDMs with chondroitinase suppressed *induced* [TNFalpha] production . Positive_regulation TNF LPL 10364070 620313 Taken together , these data suggest that ( 1 ) differentiation of human monocytes to MDMs is associated with increased LPL induced TNFalpha mRNA expression and production , ( 2 ) a protein kinase C-dependent pathway is involved in the *induction* of [TNFalpha] by in these cells , and ( 3 ) LPL effect is mediated by cell surface proteoglycans . Positive_regulation TNF LPL 10871197 706790 Besides LPL overproduction , macrophages of diabetic patients exhibited an increase in basal and *induced* [tumor necrosis factor (TNF)-alpha] release . Positive_regulation TNF LPL 15994321 1446927 We examined the *role* of in modulating [tumor necrosis factor-alpha (TNF-alpha)-] and interferon-gamma (IFN-gamma) mediated inflammatory cytokine signal transduction pathways in human aortic endothelial cells ( HAECs ) . Positive_regulation TNF LPL 2111695 132933 [Tumor necrosis factor] *induced* release of endothelial cell . Positive_regulation TNF LPL 7527452 280738 *Induction* of [tumor necrosis factor] alpha gene expression by requires protein kinase C activation . Positive_regulation TNF LPL 7527452 280739 We have previously found that *induces* [tumor necrosis factor alpha (TNF alpha)] mRNA expression and TNF alpha protein production in the ANA-1 macrophage cell line and in resident murine macrophages . Positive_regulation TNF LPL 7527452 280740 The present study was designed to elucidate the intracellular signalling pathways involved in the *induced* [TNF alpha] gene expression . Positive_regulation TNF LPL 7527452 280741 Treatment of macrophages with two protein kinase C ( PKC ) inhibitors , 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperazine hydrochloride ( H7 ) and calphostin C , suppressed *induced* [TNF alpha] mRNA expression and protein production . Positive_regulation TNF LPL 7527452 280742 Overnight treatment of ANA-1 cells with 100 ng/ml 4 beta-phorbol 12 beta-myristate 13 alpha-acetate ( PMA ) caused the suppression of both PKC activity and *induced* [TNF alpha] mRNA expression . Positive_regulation TNF LPL 7527452 280743 Overall these data demonstrate that *induces* [TNF alpha] mRNA expression in a PKC dependent manner and that the PKC effect involves transcriptional events as well as posttranscriptional modifications . Positive_regulation TNF LPL 7583927 333604 TSST-1 stimulation of *resulted* in IL-2 and [TNF] production but no IL-4 , IL-6 , or gamma interferon . Positive_regulation TNF LPL 8169531 255041 An additive effect of interferon gamma (IFN gamma) was observed on *induced* [TNF alpha] mRNA expression . Positive_regulation TNF LPL 8169531 255042 We further established that *induced* the transcription of the [TNF alpha] gene in macrophages . Positive_regulation TNF LPL 8169531 255044 These results show that the [TNF alpha] gene induction in *response* to involves both transcriptional activation and the enhancement of TNF alpha mRNA stability . Positive_regulation TNF LPL 8732780 374133 As LPL has been shown to induce macrophage TNF alpha release , the effect of reactive oxygen species on *induced* [TNF alpha] production was also examined . Positive_regulation TNF LPL 8732780 374134 Simultaneous treatment of macrophages with LPL and H2O2 or pretreatment of macrophages with H2O2 prior to LPL stimulation decreased the *induced* [TNF alpha] release by macrophages to the same extent . Positive_regulation TNF LRP2 21371423 2411526 [TNF-a] mRNA expression was increased by LPS treatment , and knockdown of the mRNA with siRNA *inhibited* LPS mediated downregulation of mRNA expression at the 24-h time point . Positive_regulation TNF LRRFIP1 23557933 2777919 The expression of the pro-inflammatory cytokines CCL3 , IL-1ß and [TNF-a] was significantly reduced and that of the transcriptional repressor *increased* in PBMCs from patients taking the GE-RES extract . Positive_regulation TNF LRRFIP1 24567534 2924718 Noncoding RNAs and *regulate* [TNF] expression . Positive_regulation TNF LSM4 12047757 950228 We found that msa reduced the expression of IL-1beta , Cox-2 , and MHC II but stimulated [TNF-alpha] while hly , rsh and *stimulated* MHC II but down-regulated TNF-alpha . Positive_regulation TNF LTA 10569762 568045 This correlated with the ability of the peptides to block *induced* production of [TNF] and interleukin-6 by RAW 264.7 cells but did not correlate with their ability to kill the bacteria . Positive_regulation TNF LTA 10569762 568047 The peptides also effectively inhibited *induced* [TNF] production in a whole human blood assay . Positive_regulation TNF LTA 10858210 704661 Both PepG and *induced* transient increases in [TNF-alpha] and IL-10 in plasma , with peak values at 6 and 12 h , respectively . Positive_regulation TNF LTA 11134043 794919 Here we show that secretion of [tumor necrosis factor-alpha] *induced* by Treponema culture supernatants and extracted was paralleled by an LBP dependent phosphorylation of mitogen activated protein kinases ( MAPKs ) p42 and p44 , and p38 , as well as the stress activated protein kinases c-Jun N-terminal kinases 1 and 2 . Positive_regulation TNF LTA 11435497 832573 The PKC inhibitor H7 reduced *dependent* secretion of [TNF-alpha] by 94 % but inhibited poly I:C dependent TNF-alpha production only by 50 % . Positive_regulation TNF LTA 11828371 909618 All *induced* the release of [TNF-alpha] , IL-1beta , IL-6 and IL-10 in human whole blood . Positive_regulation TNF LTA 11861934 917413 To evaluate in vitro activation of the neonatal immune system by specific infectious stimuli , cord blood cells from healthy neonates were examined for expression of [tumor necrosis factor-alpha (TNF-alpha)] , IL-1beta , IL-6 , and IL-8 in *response* to Streptococcus agalactiae ( GBS ) , lipopolysaccharide (LPS) , and . Positive_regulation TNF LTA 12011760 941495 However , antibodies directed towards TLR2 ( clone TL2 .1 ) or TLR4 ( clone HTA125 ) failed to inhibit [TNF-a] release *induced* by in both the whole blood model and in adherent monocytes . Positive_regulation TNF LTA 12011760 941496 In contrast , blockade of the CD14 receptor with MAb18D11 strongly attenuated the *induced* release of [TNF-alpha] in both models . Positive_regulation TNF LTA 12055225 951734 In this report , we demonstrate that LPS tolerized human promonocytic THP-1 cells develop cross-tolerance and no longer respond to *induced* [IL-1beta/TNF-alpha] production , indicating that disruption of common intracellular signaling is responsible for the decreased IL-1beta/TNF-alpha production . Positive_regulation TNF LTA 12691617 1080369 LPS-TLR4 adapted human THP-1 promonocytic cells cross-adapt to *induced* [IL-1beta/TNF-alpha] production , suggesting disruption of a common intracellular signaling event ( s ) . Positive_regulation TNF LTA 12819051 1103870 In contrast , purified *triggered* [TNF] release at 1 microg/ml. PGN-stem peptide oligomers lacking TA or amino-sugars were highly active and triggered TNF release at concentrations as low as 0.01 microg/ml ( P. A. Majcherczyk , H. Langen , et al. , J. Biol. Chem. 274 : 12537-12543,1999 ) . Positive_regulation TNF LTA 12906718 1121864 PepG and , as well as live S. aureus , *induced* the production of [TNF-alpha] and IL-6 in Kupffer cells from both species in a time- and dose dependent manner . Positive_regulation TNF LTA 1382704 198320 In certain cases in which TNF-alpha , rather than , *induces* AML growth through an autocrine mechanism , both [TNF-R] ( p55 ) and ( p75 ) are involved . Positive_regulation TNF LTA 15146415 1247786 Anti-FcgammaRIII antibody stimulation markedly enhanced the *induced* [TNFalpha] response . Positive_regulation TNF LTA 15385469 1300002 In the present study , we have started to assess the signal transduction events by which *induces* the production of [tumor necrosis factor alpha (TNF-alpha)] , interleukin-6 (IL-6) , and the anti-inflammatory cytokine IL-10 in rat Kupffer cells . Positive_regulation TNF LTA 16783405 1599403 In contrast , S. aureus ( TLR2/TLR1/TLR6 ) or Pam ( 3 ) CSK4 ( TLR2/TLR1 ) , or FSL-1 and ( TLR2/TLR6 ) *induced* [TNFalpha] without an effect on NO. 3 . Positive_regulation TNF LTA 16988837 1682739 Stimulation of human adipocytes with lipopolysaccharide (LPS) , or with , two specific ligands of TLR4 and TLR2 , respectively , *induced* a strong increase in [TNFalpha] production . Positive_regulation TNF LTA 16988837 1682740 The specificity of the response was demonstrated by the use of anti-TLR4 and anti-TLR2 blocking antibodies , which were able to decrease LPS- or *induced* [TNFalpha] secretion . Positive_regulation TNF LTA 1708843 149560 ( lymphotoxin ) strongly *upregulates* [TNF-alpha] gene expression in human peripheral blood lymphocytes . Positive_regulation TNF LTA 1708843 149561 Consistent with the results of mRNA analysis , alone did *stimulate* [TNF-alpha] secretion , but lymphocytes activated with TNF-beta/IL-2 demonstrated a 3- to 10-fold increase in secreted TNF-alpha over that induced by IL-2 alone . Positive_regulation TNF LTA 1718341 169214 2 was a potent *inducer* of [tumour necrosis factor (TNF)] and interferon ( IFN ) production and had excellent antitumour activity against Meth A fibrosarcoma established in mice . Positive_regulation TNF LTA 17196259 1695516 Pretreatment of mice with 39.5 degrees C temperature also enhanced LPS , but not , *induced* [TNF-alpha] and IL-6 production in vivo . Positive_regulation TNF LTA 17420241 1742259 purified from the bacteria *induced* [tumor necrosis factor-alpha] and IL-6 production from wild-type DCs but not from TLR2 knockout DCs , and the mutant LTA induced a significantly smaller amount of these two cytokines . Positive_regulation TNF LTA 18266269 1871881 Sequential incubation of polystyrene plates with LTA , then PPG 1200 and then blood , with washing steps in between , showed that *induced* [TNF] release was inhibited . Positive_regulation TNF LTA 18458151 1927013 Blocking CD14 and CD36 with antibodies inhibited LTA binding and *induced* [TNF] release from monocytes , emphasizing an important role for both molecules as coreceptors for TLR2 . Positive_regulation TNF LTA 18501625 1928141 We found that ApoA-I could attenuate LTA induced acute lung injury and inflammation and significantly inhibit *induced* IL-1beta and [TNF-alpha] accumulation in the serum ( P < 0.01 and P < 0.05 , respectively ) , as well as in bronchoalveolar lavage (BAL) fluid ( P < 0.01 and P < 0.05 , respectively ) . Positive_regulation TNF LTA 18600067 1935496 Inhibitory effects of Lactobacillus plantarum lipoteichoic acid (LTA) on Staphylococcus aureus *induced* [tumor necrosis factor-alpha] production . Positive_regulation TNF LTA 18845389 2012990 Upon exposure to LTA purified from Staphylococcus aureus , TNF-alpha expression was substantially induced , whereas pretreatment with PhIP significantly inhibited *induced* [TNF-alpha] expression . Positive_regulation TNF LTA 18928846 1977876 Pretreatment of LTA with calcium hydroxide remarkably abrogated the ability of to *induce* the release of [tumor necrosis factor-alpha] ( P < 0.05 ) . Positive_regulation TNF LTA 19013542 2022438 The ability of to *induce* [TNF-alpha] and NO production was abolished when the LTAs were treated with 0.2 N NaOH . Positive_regulation TNF LTA 19250703 2182412 These cells showed capacity to release [TNF-alpha] and IL-10 in *response* to all assayed in a dose dependent way . Positive_regulation TNF LTA 19250704 2182418 These data indicate that dependent TLR2 activation in odontoblasts and pulp fibroblasts , in contrast to immature DCs , does not *lead* to significant [TNF-alpha] and IL-1beta production , but that all three cell types influence the pulp inflammatory/immune response through CXCL8 synthesis and secretion . Positive_regulation TNF LTA 1972165 135337 An early intracytoplasmatic production of [TNF-alpha] after 6 h was *detected* in both monocytes and T cells whereas a late production of ( lymphotoxin ) after 48 h , occurred in the T cell population . Positive_regulation TNF LTA 19823118 2240745 In this study , we further evaluated the effects of ketamine on the regulation of *induced* [TNF-alpha] and IL-6 gene expressions and oxidative stress production in macrophages and its possible mechanisms . Positive_regulation TNF LTA 19823118 2240746 Exposure of macrophages to a therapeutic concentration of ketamine ( 100 microM ) inhibited *induced* [TNF-alpha] and IL-6 expressions at protein or mRNA levels . Positive_regulation TNF LTA 19823118 2240749 Thus , this study shows that one possible mechanism involved in ketamine induced inhibition of *induced* [TNF-alpha] and IL-6 gene expressions and oxidative stress production is through downregulating TLR2 mediated phosphorylation of ERK1/2 and the subsequent translocation and transactivation of NFkappaB . Positive_regulation TNF LTA 21238801 2379779 Recently , we have shown that calcium hydroxide , a commonly used intracanal medicament , abrogated the ability of to *stimulate* the production of [tumor necrosis factor] a in a murine macrophage line , RAW 264.7 . Positive_regulation TNF LTA 21974971 2605103 LPS , and PG *stimulated* [tumor necrosis factor (TNF)] and interleukin (IL)-6 production but only LTA and PG stimulated IL-1ß production from whole blood . Positive_regulation TNF LTA 21974971 2605106 LPS was a more potent inducer of [TNF] than either LTA or PG and both LPS and were more potent *inducers* of IL-6 than PG . Positive_regulation TNF LTA 23414215 2748831 LPS and *stimulated* [TNF alpha] , IL-10 , IL-8 and IL-6 production was studied in a 24 h whole blood assay . Positive_regulation TNF LTA 2677211 119478 Although B cells generally also produced TNF-alpha and upon stimulation , IL-4 did not *induce* [TNF] secretion and seemingly had a specific effect on IL-6 production . Positive_regulation TNF LTA 3261303 96031 Whereas whole Gram positive bacteria had no stimulatory effect on monocytes , *induced* IL-1 and [TNF] production at a concentration range equivalent to that of the LPS . Positive_regulation TNF LTA 3279996 90706 No other cellular components , such as cell wall peptidoglycan , group-specific C-carbohydrate or type-specific M protein , suppressed the growth of Meth A . , but not the other cellular components , *induced* [tumour necrosis factor (TNF)] in Propionibacterium acnes primed mice . Positive_regulation TNF LTA 8894441 392376 The combination ION + PMA *induced* the highest levels of IL-2 , IL-4 , IL-5 , IFN-gamma and [TNF-alpha] , whereas maximal production of IL-6 and were induced by PHA and PHA + PMA , respectively . Positive_regulation TNF LTA 8940232 399185 Together these observations indicate that can *trigger* macrophage activation and the production of [TNF] and NO and suggest that LTA may be an important determinant of the host inflammatory response to gram positive infection . Positive_regulation TNF LTA 8945544 400316 III-PS , GB-PS , , and PG each *induced* [TNF-alpha] in a time- and concentration dependent manner . Positive_regulation TNF LTA 9551921 499057 The TSST1 N-terminal domain ( TSST ( 1-87 ) ) did not induce proliferation of human PBLs or release of , but did *induce* [TNF-alpha] release . Positive_regulation TNF LTA 9864375 556213 Membrane retention of *resulted* indeed in receptor downmodulation and [TNF/LT-alpha] resistance . Positive_regulation TNF LTA 9925653 581360 When a maximally effective dose of LTA was mixed with lipoproteins and 10 % lipoprotein depleted plasma (LPDP) , the ability of to *stimulate* macrophage production of [TNF] was inhibited . Positive_regulation TNF LTB 11908571 923609 *stimulated* IL-1beta and [TNF-alpha] synthesis with an EC50 of 190 +/- 35 and 45 +/- 9 nmol/l , respectively . Positive_regulation TNF LTB 12117933 964676 ( 4 ) also *induced* significant [tumor necrosis factor alpha (TNF-alpha)] production , and blockade of TNF-alpha suppressed LTB ( 4 ) -induced NO release and parasite killing . Positive_regulation TNF LTB 15034048 1223607 [TNF] and phorbol esters *induce* expression through distinct pathways involving Ets and NF-kappa B family members . Positive_regulation TNF LTB 17068631 1637600 Bestatin ( 100 mg/L ) could also remarkably diminish *induced* mRNA expressions of [TNF-alpha] ( 86 % ) and IL-1beta ( 79 % ) . Positive_regulation TNF LTB 17068631 1637602 of synovial membrance cells in rheumatoid arthritis could *induce* expressions of [TNF-alpha] and IL-1beta at mRNA level , and their expression at mRNA level had been quantified successfully . Positive_regulation TNF LTB 18472956 289997 However , neither [TNFalpha] nor IL-1beta *induced* a significant ( 4 ) production in SMC alone or AM alone after 24 h of incubation . Positive_regulation TNF LTB 19168089 2113946 In contrast to the results obtained with the B subunits , incubation of cells with the A subunit of CT (CTA) inhibit [TNF-alpha] release *induced* by native CT , native LT , recombinant and LPS . Positive_regulation TNF LTB 19809821 2271948 Exogenous remarkably *increased* the expression of [TNFalpha] and IL1beta at both the mRNA level and the protein level . Positive_regulation TNF LTB 24913232 2946498 In vitro , neutrophils adherent to ICAM-1 or ICAM-2 rapidly released [TNF] in *response* to , C5a , and KC . Positive_regulation TNF LTB 2540688 110422 We next examined the *role* of in mineral-dust induced [TNF] production . Positive_regulation TNF LTB 8382842 212184 Pretreatment of rats by lavage into airways with actinomycin D , 12 ng in 0.1 ml , minimized *induced* [TNF] synthesis after 1 1/2 and 3 hours ( 38 and 51 pg/ml ) , as well as the delayed diapedesis after 4 hours ( 12 PMN/ml ) ( all p < 0.05 ) . Positive_regulation TNF LTF 10580998 570181 itself did not *induce* either [tumor necrosis factor-alpha] production or nitric oxide production , but lipopolysaccharide stimulated tumor necrosis factor-alpha production of macrophages and monocytes were inhibited by lactoferrin treatment combined with stimulant . Positive_regulation TNF LTF 9315285 455762 Secretion of [TNF-alpha] peaked at 6 h of incubation in the *presence* of and then declined . Positive_regulation TNF LTF 9704149 525552 alone was a good *inducer* of IL-6 and [TNF-alpha] production by monoclear cells in vitro . Positive_regulation TNF LTF 9704149 525554 is a good *inducer* of IL-6 and [TNF-alpha] production . Positive_regulation TNF LTK 11067933 747514 In contrast , *augmented* the production of IL-12 and [TNF-alpha] . Positive_regulation TNF LYG1 22909797 2687786 Our results indicated that significantly *increased* the cytostatic and proapoptotic activity of [TNF-a] in HepG2 cells and heightened the protein level of apoptosis related genes including caspase-3 , caspase-8/9 , cleaved poly ( ADP-ribose ) polymerase , and Bid . Positive_regulation TNF LYG2 22909797 2687787 Our results indicated that significantly *increased* the cytostatic and proapoptotic activity of [TNF-a] in HepG2 cells and heightened the protein level of apoptosis related genes including caspase-3 , caspase-8/9 , cleaved poly ( ADP-ribose ) polymerase , and Bid . Positive_regulation TNF LYZ 22724024 2616754 In a previous work HZ was shown to *induce* through [TNFalpha] production the release of monocytic , an enzyme stored in gelatinase granules with MMP-9 . Positive_regulation TNF MACROD1 23389992 2780993 In contrast , overexpression *increased* [TNF-a] secretion , suppressed glucose uptake , and attenuated 3T3-L1 cell differentiation . Positive_regulation TNF MADCAM1 11481030 894884 [TNF-alpha] *induced* endothelial expression is regulated by exogenous , not endogenous nitric oxide . Positive_regulation TNF MADCAM1 12003644 1011663 was *induced* by [TNF-a] . Positive_regulation TNF MADCAM1 12625840 1066714 we then examined [TNF-alpha] *induced* lymphocyte adhesion to lymphatic endothelial cells and TNF-alpha induced expression of and compared these responses to control monolayers . Positive_regulation TNF MADCAM1 14742547 1203429 Furthermore , we show that can be *induced* on human endothelial cells by [tumor necrosis factor alpha (TNF-alpha)] and gamma interferon . Positive_regulation TNF MADCAM1 15735432 1378429 [TNF-alpha] *induced* in a dose dependent manner by 24 hours . Positive_regulation TNF MADCAM1 15735432 1378431 In vitro , can be *induced* on colon endothelial cells by [TNF-alpha] stimulation and may represent a useful model to study microvascular injury in the large intestine . Positive_regulation TNF MADCAM1 7724598 301984 Expression of is *induced* in the murine endothelial cell line bEnd.3 by [tumor necrosis factor alpha (TNF-alpha)] , interleukin 1 , and bacterial lipopolysaccharide . Positive_regulation TNF MADCAM1 9678753 520702 Splenic expression , follicular dendritic cell localization and normal Peyer 's patch development all *require* both surface LT-alphabeta and [TNF] activity . Positive_regulation TNF MADD 10521481 653126 Furthermore , overexpression of ( MAP kinase activating death domain protein ) , an adapter protein that binds to the death domain of TNFR1 and activates MAP kinase cascades , *results* in CRE dependent induction of [TNF-alpha] gene expression . Positive_regulation TNF MAF 2150351 149369 Although calcium ionophore A23187 and ( both can activate M phi to mediate tumoricidal activity ) did not *induce* [TNF-alpha] mRNA expression by themselves , they did act synergistically with LPS . Positive_regulation TNF MAFB 22820162 2646124 Retinoic acid and [tumor necrosis factor-a] induced monocytic cell gene expression is *regulated* in part by induction of . Positive_regulation TNF MAGEA1 15944290 1416146 Human scFv-G8 ( POS ) T lymphocytes comprising the gamma + CD28 vs the gamma signaling element alone produced substantially more IL-2 , [TNF-alpha] , and IFN-gamma in *response* to ( POS ) melanoma cells . Positive_regulation TNF MAGEE1 23619393 2790341 to the central nervous system ( CNS ) *leads* to increased production of [TNF-a] and TGF-ß1 cytokines that have pro- or anti-inflammatory actions , respectively . Positive_regulation TNF MAGI1 12061424 952852 In agreement , MT-III and did not *induce* the synthesis of [TNF-alpha] by resident peritoneal macrophages in vitro . Positive_regulation TNF MAGI2 15310755 1303536 [TNF] binding *induces* release of from TNFR1 , resulting in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD , RIP1 , TRAF2 , and AIPl . Positive_regulation TNF MAL 18070880 1861742 In this study we examined whether tyrosine phosphorylation of *regulates* its interactions with TLR4 , MyD88 , interleukin-1 (IL-1) receptor associated kinase ( IRAK)-2 , and [tumor necrosis factor] receptor associated factor ( TRAF)-6 and is important for signaling . Positive_regulation TNF MAOB 19779138 2147555 These results suggest that LPS induces chronic wounds via elevated *mediated* increases in H ( 2 ) O ( 2 ) and [TNF-alpha] activity by epithelial cells and is further associated with more distant effects on systemic oxidative stress and alveolar bone loss . Positive_regulation TNF MAP2K1 11234901 789740 Basal and [tumor necrosis factor-alpha-inducible] phosphorylation of ERK1/2 and secretion of IL-8 and VEGF could be specifically *inhibited* by a inhibitor , U0126 . Positive_regulation TNF MAP2K1 11994488 939076 These findings were supported by functional data demonstrating that CQ and PD98059 interfered with TNF expression in several human and murine cell types while neither inhibitor blocked TNF production in murine RAW264.7 macrophages , a cell line that does not *require* signaling for [TNF] production . Positive_regulation TNF MAP2K1 12506070 1038314 A specific inhibitor of *blocked* the [TNFalpha] induction of the MMPs and TIMPs and the phosphorylation of Erk . Positive_regulation TNF MAP2K1 12930919 1164049 These effects are mediated through both and PI 3-kinase pathways but not through the IGF-I *induction* of [TNF-alpha] production by the DC . Positive_regulation TNF MAP2K1 14566965 1155095 In both prechondrocytes and articular chondrocytes , [TNFalpha] *induced* concentration dependent activation of and NF-kappaB , but not p38 or JNK . Positive_regulation TNF MAP2K1 17382207 1715503 Inhibitors of both PKC and largely *prevented* Prdx6 induction by KGF and , to a lesser extent , [TNF-alpha] . Positive_regulation TNF MAP2K1 18187448 1856714 We show that LPS stimulates the appearance of [pre-TNFalpha] at the cell surface and that this is *prevented* by inhibition of or in TPL2-deficient macrophages . Positive_regulation TNF MAP2K1 19447225 2078690 Lopinavir induced cytosolic translocation of HuR and [TNF-alpha] and IL-6 synthesis was *attenuated* by specific chemical inhibitor of ( PD98058 ) or over-expression of dominant negative mutant of MEK1 . Positive_regulation TNF MAP2K1 20398804 2293950 Adding inhibitor in the presence of p38 inhibitor further *reduced* [TNFalpha] release suggesting that the ERK pathway plays a role in GM-CSF induced reduction of the p38 inhibitor potency . Positive_regulation TNF MAP2K1 22022968 2499139 [TNF-a] production by both strains was reduced in the *presence* of specific inhibitors of ( PD98059 ) , p38 ( SB203580 ) , and NF-?B ( BAY 11-7082 ) . Positive_regulation TNF MAP2K1 24151609 2859735 [TNF] a mediated IL-6 secretion is *regulated* by JAK/STAT pathway but not by phosphorylation and AKT phosphorylation in U266 multiple myeloma cells . Positive_regulation TNF MAP2K1 25131930 2957316 Hepatitis C virus core protein enhances HIV-1 replication in human macrophages through TLR2 , JNK , and *dependent* upregulation of [TNF-a] and IL-6 . Positive_regulation TNF MAP2K1 8900184 393456 *Activation* of 6 by osmotic shock , [tumor necrosis factor-alpha] , and H2O2 . Positive_regulation TNF MAP2K1 9766635 538479 [TNF-alpha] and GM-CSF priming of superoxide release stimulated by N-formyl-methionyl-leucyl-phenylalanine was significantly *attenuated* by the inhibitor , PD098059 , and the p38 MAPK inhibitor , SB203580 . Positive_regulation TNF MAP2K1 9864179 582677 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of ERK , but not p38 MAPK , induced by G-CSF , GM-CSF , or [TNF] . Positive_regulation TNF MAP2K2 11234901 789741 Basal and [tumor necrosis factor-alpha-inducible] phosphorylation of ERK1/2 and secretion of IL-8 and VEGF could be specifically *inhibited* by a inhibitor , U0126 . Positive_regulation TNF MAP2K2 11994488 939077 These findings were supported by functional data demonstrating that CQ and PD98059 interfered with TNF expression in several human and murine cell types while neither inhibitor blocked TNF production in murine RAW264.7 macrophages , a cell line that does not *require* signaling for [TNF] production . Positive_regulation TNF MAP2K2 12506070 1038315 A specific inhibitor of *blocked* the [TNFalpha] induction of the MMPs and TIMPs and the phosphorylation of Erk . Positive_regulation TNF MAP2K2 12930919 1164050 These effects are mediated through both and PI 3-kinase pathways but not through the IGF-I *induction* of [TNF-alpha] production by the DC . Positive_regulation TNF MAP2K2 17382207 1715504 Inhibitors of both PKC and largely *prevented* Prdx6 induction by KGF and , to a lesser extent , [TNF-alpha] . Positive_regulation TNF MAP2K2 19447225 2078691 Lopinavir induced cytosolic translocation of HuR and [TNF-alpha] and IL-6 synthesis was *attenuated* by specific chemical inhibitor of ( PD98058 ) or over-expression of dominant negative mutant of MEK1 . Positive_regulation TNF MAP2K2 20398804 2293951 Adding inhibitor in the presence of p38 inhibitor further *reduced* [TNFalpha] release suggesting that the ERK pathway plays a role in GM-CSF induced reduction of the p38 inhibitor potency . Positive_regulation TNF MAP2K2 22022968 2499140 [TNF-a] production by both strains was *reduced* in the presence of specific inhibitors of ( PD98059 ) , p38 ( SB203580 ) , and NF-?B ( BAY 11-7082 ) . Positive_regulation TNF MAP2K2 24151609 2859736 [TNF] a mediated IL-6 secretion is *regulated* by JAK/STAT pathway but not by phosphorylation and AKT phosphorylation in U266 multiple myeloma cells . Positive_regulation TNF MAP2K2 8900184 393457 *Activation* of 6 by osmotic shock , [tumor necrosis factor-alpha] , and H2O2 . Positive_regulation TNF MAP2K2 9766635 538480 [TNF-alpha] and GM-CSF priming of superoxide release stimulated by N-formyl-methionyl-leucyl-phenylalanine was significantly *attenuated* by the inhibitor , PD098059 , and the p38 MAPK inhibitor , SB203580 . Positive_regulation TNF MAP2K2 9864179 582678 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of ERK , but not p38 MAPK , induced by G-CSF , GM-CSF , or [TNF] . Positive_regulation TNF MAP2K3 11234901 789742 Basal and [tumor necrosis factor-alpha-inducible] phosphorylation of ERK1/2 and secretion of IL-8 and VEGF could be specifically *inhibited* by a inhibitor , U0126 . Positive_regulation TNF MAP2K3 11994488 939078 These findings were supported by functional data demonstrating that CQ and PD98059 interfered with TNF expression in several human and murine cell types while neither inhibitor blocked TNF production in murine RAW264.7 macrophages , a cell line that does not *require* signaling for [TNF] production . Positive_regulation TNF MAP2K3 12506070 1038316 A specific inhibitor of *blocked* the [TNFalpha] induction of the MMPs and TIMPs and the phosphorylation of Erk . Positive_regulation TNF MAP2K3 12930919 1164051 These effects are mediated through both and PI 3-kinase pathways but not through the IGF-I *induction* of [TNF-alpha] production by the DC . Positive_regulation TNF MAP2K3 14695331 1195027 levels were low in medium treated FLS , but were rapidly *increased* by interleukin-1 and [tumor necrosis factor-alpha] , although phospho-MKK6 levels only modestly increased . Positive_regulation TNF MAP2K3 17382207 1715505 Inhibitors of both PKC and largely *prevented* Prdx6 induction by KGF and , to a lesser extent , [TNF-alpha] . Positive_regulation TNF MAP2K3 19447225 2078692 Lopinavir induced cytosolic translocation of HuR and [TNF-alpha] and IL-6 synthesis was *attenuated* by specific chemical inhibitor of ( PD98058 ) or over-expression of dominant negative mutant of MEK1 . Positive_regulation TNF MAP2K3 20004242 2199801 In contrast , p38delta activation by ultraviolet radiation , hyperosmotic shock , anisomycin or by [TNFalpha] is *mediated* by . Positive_regulation TNF MAP2K3 20398804 2293952 Adding inhibitor in the presence of p38 inhibitor further *reduced* [TNFalpha] release suggesting that the ERK pathway plays a role in GM-CSF induced reduction of the p38 inhibitor potency . Positive_regulation TNF MAP2K3 22022968 2499141 [TNF-a] production by both strains was reduced in the *presence* of specific inhibitors of ( PD98059 ) , p38 ( SB203580 ) , and NF-?B ( BAY 11-7082 ) . Positive_regulation TNF MAP2K3 24151609 2859737 [TNF] a mediated IL-6 secretion is *regulated* by JAK/STAT pathway but not by phosphorylation and AKT phosphorylation in U266 multiple myeloma cells . Positive_regulation TNF MAP2K3 8900184 393458 *Activation* of 6 by osmotic shock , [tumor necrosis factor-alpha] , and H2O2 . Positive_regulation TNF MAP2K3 9766635 538481 [TNF-alpha] and GM-CSF priming of superoxide release stimulated by N-formyl-methionyl-leucyl-phenylalanine was significantly *attenuated* by the inhibitor , PD098059 , and the p38 MAPK inhibitor , SB203580 . Positive_regulation TNF MAP2K3 9864179 582679 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of ERK , but not p38 MAPK , induced by G-CSF , GM-CSF , or [TNF] . Positive_regulation TNF MAP2K4 11234901 789743 Basal and [tumor necrosis factor-alpha-inducible] phosphorylation of ERK1/2 and secretion of IL-8 and VEGF could be specifically *inhibited* by a inhibitor , U0126 . Positive_regulation TNF MAP2K4 11994488 939079 These findings were supported by functional data demonstrating that CQ and PD98059 interfered with TNF expression in several human and murine cell types while neither inhibitor blocked TNF production in murine RAW264.7 macrophages , a cell line that does not *require* signaling for [TNF] production . Positive_regulation TNF MAP2K4 12426318 1036873 In the latter cell type , overexpression of antisense c-jun mRNA or of a dominant negative form of *blocked* the inhibitory activity of [TNF-alpha] , similar to what was observed in normal human dermal fibroblasts . Positive_regulation TNF MAP2K4 12506070 1038317 A specific inhibitor of *blocked* the [TNFalpha] induction of the MMPs and TIMPs and the phosphorylation of Erk . Positive_regulation TNF MAP2K4 12930919 1164052 These effects are mediated through both and PI 3-kinase pathways but not through the IGF-I *induction* of [TNF-alpha] production by the DC . Positive_regulation TNF MAP2K4 17382207 1715506 Inhibitors of both PKC and largely *prevented* Prdx6 induction by KGF and , to a lesser extent , [TNF-alpha] . Positive_regulation TNF MAP2K4 19447225 2078693 Lopinavir induced cytosolic translocation of HuR and [TNF-alpha] and IL-6 synthesis was *attenuated* by specific chemical inhibitor of ( PD98058 ) or over-expression of dominant negative mutant of MEK1 . Positive_regulation TNF MAP2K4 20398804 2293953 Adding inhibitor in the presence of p38 inhibitor further *reduced* [TNFalpha] release suggesting that the ERK pathway plays a role in GM-CSF induced reduction of the p38 inhibitor potency . Positive_regulation TNF MAP2K4 22022968 2499142 [TNF-a] production by both strains was *reduced* in the presence of specific inhibitors of ( PD98059 ) , p38 ( SB203580 ) , and NF-?B ( BAY 11-7082 ) . Positive_regulation TNF MAP2K4 24151609 2859738 [TNF] a mediated IL-6 secretion is *regulated* by JAK/STAT pathway but not by phosphorylation and AKT phosphorylation in U266 multiple myeloma cells . Positive_regulation TNF MAP2K4 8900184 393459 *Activation* of 6 by osmotic shock , [tumor necrosis factor-alpha] , and H2O2 . Positive_regulation TNF MAP2K4 9006895 410732 Actin binding protein-280 binds the stress activated protein kinase ( SAPK ) activator and is *required* for [tumor necrosis factor-alpha] activation of SAPK in melanoma cells . Positive_regulation TNF MAP2K4 9766635 538482 [TNF-alpha] and GM-CSF priming of superoxide release stimulated by N-formyl-methionyl-leucyl-phenylalanine was significantly *attenuated* by the inhibitor , PD098059 , and the p38 MAPK inhibitor , SB203580 . Positive_regulation TNF MAP2K4 9864179 582680 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of ERK , but not p38 MAPK , induced by G-CSF , GM-CSF , or [TNF] . Positive_regulation TNF MAP2K5 11234901 789744 Basal and [tumor necrosis factor-alpha-inducible] phosphorylation of ERK1/2 and secretion of IL-8 and VEGF could be specifically *inhibited* by a inhibitor , U0126 . Positive_regulation TNF MAP2K5 11274363 797649 *Role* of in the regulation of [TNF-alpha] gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells . Positive_regulation TNF MAP2K5 11994488 939080 These findings were supported by functional data demonstrating that CQ and PD98059 interfered with TNF expression in several human and murine cell types while neither inhibitor blocked TNF production in murine RAW264.7 macrophages , a cell line that does not *require* signaling for [TNF] production . Positive_regulation TNF MAP2K5 12506070 1038318 A specific inhibitor of *blocked* the [TNFalpha] induction of the MMPs and TIMPs and the phosphorylation of Erk . Positive_regulation TNF MAP2K5 12930919 1164053 These effects are mediated through both and PI 3-kinase pathways but not through the IGF-I *induction* of [TNF-alpha] production by the DC . Positive_regulation TNF MAP2K5 15367687 1294825 The dominant negative also *prevented* flow mediated inhibition of [tumor necrosis factor] alpha mediated NF-kappaB activation and adhesion molecule expression , including vascular cellular adhesion molecule 1 and E-selectin , indicating a physiological role for ERK5 and PPARgamma activation in flow mediated antiinflammatory effects . Positive_regulation TNF MAP2K5 17382207 1715507 Inhibitors of both PKC and largely *prevented* Prdx6 induction by KGF and , to a lesser extent , [TNF-alpha] . Positive_regulation TNF MAP2K5 19447225 2078694 Lopinavir induced cytosolic translocation of HuR and [TNF-alpha] and IL-6 synthesis was *attenuated* by specific chemical inhibitor of ( PD98058 ) or over-expression of dominant negative mutant of MEK1 . Positive_regulation TNF MAP2K5 20398804 2293954 Adding inhibitor in the presence of p38 inhibitor further *reduced* [TNFalpha] release suggesting that the ERK pathway plays a role in GM-CSF induced reduction of the p38 inhibitor potency . Positive_regulation TNF MAP2K5 21166929 2385271 is activated by shear stress , activates ERK5 and *induces* KLF4 to modulate [TNF] responses in human dermal microvascular endothelial cells . Positive_regulation TNF MAP2K5 22022968 2499143 [TNF-a] production by both strains was reduced in the *presence* of specific inhibitors of ( PD98059 ) , p38 ( SB203580 ) , and NF-?B ( BAY 11-7082 ) . Positive_regulation TNF MAP2K5 24151609 2859739 [TNF] a mediated IL-6 secretion is *regulated* by JAK/STAT pathway but not by phosphorylation and AKT phosphorylation in U266 multiple myeloma cells . Positive_regulation TNF MAP2K5 8900184 393460 *Activation* of 6 by osmotic shock , [tumor necrosis factor-alpha] , and H2O2 . Positive_regulation TNF MAP2K5 9766635 538483 [TNF-alpha] and GM-CSF priming of superoxide release stimulated by N-formyl-methionyl-leucyl-phenylalanine was significantly *attenuated* by the inhibitor , PD098059 , and the p38 MAPK inhibitor , SB203580 . Positive_regulation TNF MAP2K5 9864179 582681 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of ERK , but not p38 MAPK , induced by G-CSF , GM-CSF , or [TNF] . Positive_regulation TNF MAP2K6 11234901 789745 Basal and [tumor necrosis factor-alpha-inducible] phosphorylation of ERK1/2 and secretion of IL-8 and VEGF could be specifically *inhibited* by a inhibitor , U0126 . Positive_regulation TNF MAP2K6 11994488 939081 These findings were supported by functional data demonstrating that CQ and PD98059 interfered with TNF expression in several human and murine cell types while neither inhibitor blocked TNF production in murine RAW264.7 macrophages , a cell line that does not *require* signaling for [TNF] production . Positive_regulation TNF MAP2K6 12506070 1038319 A specific inhibitor of *blocked* the [TNFalpha] induction of the MMPs and TIMPs and the phosphorylation of Erk . Positive_regulation TNF MAP2K6 12930919 1164054 These effects are mediated through both and PI 3-kinase pathways but not through the IGF-I *induction* of [TNF-alpha] production by the DC . Positive_regulation TNF MAP2K6 15867183 1404196 In cultured cardiac myocytes , specific activation of stress activated mitogen activated protein kinase , p38 , by upstream activator *led* to significant induction of [tumor necrosis factor-alpha] and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation TNF MAP2K6 17382207 1715508 Inhibitors of both PKC and largely *prevented* Prdx6 induction by KGF and , to a lesser extent , [TNF-alpha] . Positive_regulation TNF MAP2K6 19447225 2078695 Lopinavir induced cytosolic translocation of HuR and [TNF-alpha] and IL-6 synthesis was *attenuated* by specific chemical inhibitor of ( PD98058 ) or over-expression of dominant negative mutant of MEK1 . Positive_regulation TNF MAP2K6 20398804 2293955 Adding inhibitor in the presence of p38 inhibitor further *reduced* [TNFalpha] release suggesting that the ERK pathway plays a role in GM-CSF induced reduction of the p38 inhibitor potency . Positive_regulation TNF MAP2K6 22022968 2499144 [TNF-a] production by both strains was *reduced* in the presence of specific inhibitors of ( PD98059 ) , p38 ( SB203580 ) , and NF-?B ( BAY 11-7082 ) . Positive_regulation TNF MAP2K6 24151609 2859740 [TNF] a mediated IL-6 secretion is *regulated* by JAK/STAT pathway but not by phosphorylation and AKT phosphorylation in U266 multiple myeloma cells . Positive_regulation TNF MAP2K6 8900184 393461 *Activation* of 6 by osmotic shock , [tumor necrosis factor-alpha] , and H2O2 . Positive_regulation TNF MAP2K6 9766635 538484 [TNF-alpha] and GM-CSF priming of superoxide release stimulated by N-formyl-methionyl-leucyl-phenylalanine was significantly *attenuated* by the inhibitor , PD098059 , and the p38 MAPK inhibitor , SB203580 . Positive_regulation TNF MAP2K6 9864179 582682 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of ERK , but not p38 MAPK , induced by G-CSF , GM-CSF , or [TNF] . Positive_regulation TNF MAP2K7 11234901 789746 Basal and [tumor necrosis factor-alpha-inducible] phosphorylation of ERK1/2 and secretion of IL-8 and VEGF could be specifically *inhibited* by a inhibitor , U0126 . Positive_regulation TNF MAP2K7 11994488 939082 These findings were supported by functional data demonstrating that CQ and PD98059 interfered with TNF expression in several human and murine cell types while neither inhibitor blocked TNF production in murine RAW264.7 macrophages , a cell line that does not *require* signaling for [TNF] production . Positive_regulation TNF MAP2K7 12506070 1038320 A specific inhibitor of *blocked* the [TNFalpha] induction of the MMPs and TIMPs and the phosphorylation of Erk . Positive_regulation TNF MAP2K7 12930919 1164055 These effects are mediated through both and PI 3-kinase pathways but not through the IGF-I *induction* of [TNF-alpha] production by the DC . Positive_regulation TNF MAP2K7 15979653 1428400 Recombinant constitutively active adenovirus ( Ad ) -MKK6 *increased* [TNF-alpha] production in KCs with activation of P38 and JNK without any change by Ad-MEK1 delivery . Positive_regulation TNF MAP2K7 17382207 1715509 Inhibitors of both PKC and largely *prevented* Prdx6 induction by KGF and , to a lesser extent , [TNF-alpha] . Positive_regulation TNF MAP2K7 19447225 2078696 Lopinavir induced cytosolic translocation of HuR and [TNF-alpha] and IL-6 synthesis was *attenuated* by specific chemical inhibitor of ( PD98058 ) or over-expression of dominant negative mutant of MEK1 . Positive_regulation TNF MAP2K7 20398804 2293956 Adding inhibitor in the presence of p38 inhibitor further *reduced* [TNFalpha] release suggesting that the ERK pathway plays a role in GM-CSF induced reduction of the p38 inhibitor potency . Positive_regulation TNF MAP2K7 22022968 2499145 [TNF-a] production by both strains was reduced in the *presence* of specific inhibitors of ( PD98059 ) , p38 ( SB203580 ) , and NF-?B ( BAY 11-7082 ) . Positive_regulation TNF MAP2K7 24151609 2859741 [TNF] a mediated IL-6 secretion is *regulated* by JAK/STAT pathway but not by phosphorylation and AKT phosphorylation in U266 multiple myeloma cells . Positive_regulation TNF MAP2K7 8900184 393462 *Activation* of 6 by osmotic shock , [tumor necrosis factor-alpha] , and H2O2 . Positive_regulation TNF MAP2K7 9766635 538485 [TNF-alpha] and GM-CSF priming of superoxide release stimulated by N-formyl-methionyl-leucyl-phenylalanine was significantly *attenuated* by the inhibitor , PD098059 , and the p38 MAPK inhibitor , SB203580 . Positive_regulation TNF MAP2K7 9864179 582683 inhibitor ( PD98059 ) *reduced* tyrosine phosphorylation of ERK , but not p38 MAPK , induced by G-CSF , GM-CSF , or [TNF] . Positive_regulation TNF MAP3K1 10852963 704083 is not *required* for [TNFalpha] or IL-1 regulation of JNK or NF-kappaB activation in macrophages or fibroblasts . Positive_regulation TNF MAP3K1 9177222 434129 Expression of activated ( DeltaMEKK1 ) in MC/9 cells strongly stimulated JNK activity but only weakly stimulated p38 activity , and it *induced* a large activation of [TNF-alpha] promoter regulated luciferase gene expression . Positive_regulation TNF MAP3K14 12867425 1141841 A role for NF-kappaB essential modifier/IkappaB kinase-gamma ( NEMO/IKKgamma ) ubiquitination in the *activation* of the by [tumor necrosis factor-alpha] . Positive_regulation TNF MAP3K2 11274363 797650 *Role* of in the regulation of [TNF-alpha] gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells . Positive_regulation TNF MAP3K2 14978743 1213702 Bacterial lipopolysaccharide (LPS) and [TNFalpha] neither activate ERK5 nor *require* for JNK activation , demonstrating specificity of MEKK2 in FGF-2 receptor signaling and control of cytokine gene expression . Positive_regulation TNF MAP3K3 12065326 954392 Gab1 associated with MEKK3 , and a catalytically inactive form of MEKK3 inhibited TNF-alpha induced c-Jun and NF-kappaB transcriptional activation , suggesting a critical *role* for Gab1 and in [TNF-alpha] signaling . Positive_regulation TNF MAP3K4 9305639 454086 Overexpression of a dominant negative mutant [ MTK1 ( K/R ) ] strongly *inhibited* the activation of the p38 pathway by environmental stresses ( osmotic shock , UV and anisomycin ) , but not the p38 activation by the cytokine [TNF-alpha] . Positive_regulation TNF MAP3K5 10688666 670138 Thus , *activation* of by [TNF] requires the ROS mediated dissociation of Trx possibly followed by the binding of TRAF2 and consequent ASK1 homo-oligomerization . Positive_regulation TNF MAP3K5 11285311 799847 Steady laminar flow inhibited both [TNF] *activation* of and JNK . Positive_regulation TNF MAP3K5 16407264 1527394 We have previously shown that undergoes ubiquitination and degradation in resting endothelial cells ( EC ) and that proinflammatory cytokine [tumor necrosis factor (TNF)] *induces* deubiquitination and stabilization , leading to ASK1 activation . Positive_regulation TNF MAP3K5 18292600 1891528 Endogenous AIP1-PP2A complex can be detected in the resting state , and [TNF] *induces* a complex formation of AIP1-PP2A with . Positive_regulation TNF MAP3K5 20438834 2282713 These studies show that [TNFalpha] *increases* oxidative stress in mice with elevated CYP2E1 , with subsequent activation of via a mechanism involving thioredoxin-ASK-1 dissociation , followed by activation of downstream MKK and MAPK . Positive_regulation TNF MAP3K5 24371084 2911650 Phosphorylated increased in wild-type mouse brains , and phosphorylated p38 and [tumor necrosis factor-a] expression *increased* in corpus callosum cerebral endothelial cells after BCAS in wild-type mice but not in ASK1 ( -/- ) mice . Positive_regulation TNF MAP3K7 10187861 603059 Furthermore , [tumor necrosis factor-alpha] activated endogenous TAK1 , and the kinase negative *acted* as a dominant negative inhibitor against tumor necrosis factor-alpha induced NF-kappaB activation . Positive_regulation TNF MAP3K7 15590691 1368802 Immunoblotting with a novel phospho-TAK1 antibody revealed that [TNF-alpha] significantly *induced* the phosphorylation of endogenous at Thr-187 , and subsequently the phosphorylated forms of TAK1 rapidly disappeared . Positive_regulation TNF MAP3K7 16385569 1533417 Activation of endogenous , a mitogen activated protein kinase ( MAP3K ) regulating the JNK and p38 MAPK pathways , was *induced* rapidly by [TNF-alpha] , and co-transfection of TAK1 with its activator protein TAB1 stimulated activation of JNK and p38 MAPKs , which led to activation of the transcription factor AP-1 . Positive_regulation TNF MAP3K7 17052891 1683805 In this study , a critical *role* for in IL-1alpha or [TNFalpha] stimulated MAPK and NFkappaB activation was confirmed by inhibition of the nuclear accumulation of NFkappaB p65 and phosphorylated forms of c-Jun and p38 following siRNA mediated TAK1 silencing . Positive_regulation TNF MAP3K7 17348859 1733934 We also show that MDP activates ERK1 ( extracellular-signal regulated kinase 1 ) /ERK2 and p38alpha MAPK in human peripheral-blood mononuclear cells and that the activity of both MAPKs and are *required* for MDP induced signalling and production of IL-1beta and [TNFalpha] in these cells . Positive_regulation TNF MAP3K7 18829460 1988054 [Tumor necrosis factor-] and interleukin-1 induced *activation* of was entirely normal in Tab1-deficient MEFs and could activate both mitogen activated protein kinases and NF-kappaB . Positive_regulation TNF MAP3K7 21335610 2443387 In general , crucially *regulates* IL-1 and [TNF] signalling in fibroblasts . Positive_regulation TNF MAP3K8 15575964 1347772 Animal and tissue culture studies have shown that is *involved* in interleukin-2 (IL-2) and [tumor necrosis factor-alpha (TNF-alpha)] production by T-cells contributing to T-cell proliferation . Positive_regulation TNF MAP3K8 15833743 1418004 In addition , we show that the *activation* of by [TNF-alpha] depends on signals transduced by both TRAF2 and RIP1 . Positive_regulation TNF MAP3K8 17848581 1817811 Moreover , is *required* for [TNFalpha] expression . Positive_regulation TNF MAP3K8 21135874 2373019 is *critical* for production of the proinflammatory cytokine [TNF] during inflammatory responses . Positive_regulation TNF MAP3K8 22733995 2639214 Unexpectedly , *promoted* soluble [TNF] production independently of IKK induced p105 phosphorylation and its ability to activate ERK , which has important implications for the development of anti-inflammatory drugs targeting TPL-2 . Positive_regulation TNF MAP4K4 16461467 1522663 Furthermore , [TNF-alpha] signaling to down-regulate GLUT4 is *impaired* in the absence of , indicating that MAP4K4 expression is required for optimal TNF-alpha action . Positive_regulation TNF MAP4K4 17500068 1761785 [TNFalpha] signaling decreases peroxisome proliferator activated receptor gamma and glucose transporter isoform 4 (GLUT4) expression in adipocytes , impairing insulin action , and this is *mediated* in part by the yeast Ste20 protein kinase ortholog . Positive_regulation TNF MAP4K5 9754676 535208 Moreover , *had* a significant inhibitory effect on anti-DNP IgE induced [tumor necrosis factor-alpha (TNF-alpha)] secretion from RPMC . Positive_regulation TNF MAPK1 10079106 595505 Specific inhibitors of p38alpha *blocked* LPS induced adhesion , nuclear factor-kappa B (NF-kappaB) activation , and synthesis of [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF MAPK1 10079106 595559 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Positive_regulation TNF MAPK1 10079106 595572 These findings support a pathway by which LPS stimulation of neutrophils results in activation of MKK3 , which in turn activates p38alpha , ultimately regulating adhesion , NF-kappaB activation , *enhanced* gene expression of [TNF-alpha] , and regulation of TNF-alpha synthesis . Positive_regulation TNF MAPK1 10201904 605666 [TNF-alpha] *induced* tyrosine phosphorylation and enzymatic activation of , SAPK/JNK , and p38mapk , whereas IL-10 did not induce these events . Positive_regulation TNF MAPK1 10210635 607635 ( 1 ) The human heart produces TNF-alpha after I/R , ( 2 ) p38 *mediates* myocardial I/R induced [TNF-alpha] production , ( 3 ) p38 MAPK inhibition limits functional impairment after I/R , and ( 4 ) inhibition of ischemia induced TNF-alpha production may represent a potent therapeutic strategy for improving myocardial function after angioplasty , coronary bypass , or heart transplantation . Positive_regulation TNF MAPK1 10329111 613023 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Positive_regulation TNF MAPK1 10521481 653034 Engagement of tumor necrosis factor (TNF) receptor 1 leads to ATF-2- and p38 *dependent* [TNF-alpha] gene expression . Positive_regulation TNF MAPK1 10521481 653092 The study presented here shows that autoregulation of [TNF-alpha] gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation TNF MAPK1 10559258 566513 Kinase-defective point and deletion variants of RIP2 also significantly blocked the *activation* of by [TNFalpha] but not epidermal growth factor . Positive_regulation TNF MAPK1 10586056 571698 Ligation of microglial CD40 results in p44/42 *dependent* [TNF-alpha] production that is opposed by TGF-beta 1 and IL-10 . Positive_regulation TNF MAPK1 10586056 571752 Inhibition of the upstream activator of p44/42 , mitogen activated protein/extracellular signal related kinase kinase 1/2 , with PD98059 , decreases phosphorylation of p44/42 MAPK and significantly *reduces* [TNF-alpha] release following ligation of microglial CD40 . Positive_regulation TNF MAPK1 10601128 574171 [Tumor necrosis factor-alpha (TNF-alpha)] alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation TNF MAPK1 10620700 657665 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Positive_regulation TNF MAPK1 10653605 663290 These results suggest that ( 1 ) while PTK and are *essential* for the production of [TNFalpha] , they are not necessary for the induction of MnSOD by LPS , and ( 2 ) while activation of NFkappaB alone is insufficient for the induction of TNFalpha mRNA by LPS , it is necessary for the induction of TNFalpha as well as MnSOD mRNAs . Positive_regulation TNF MAPK1 10655266 663522 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Positive_regulation TNF MAPK1 10657669 664185 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Positive_regulation TNF MAPK1 10669634 665790 In this study , we show that [TNF-alpha] *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation TNF MAPK1 10764820 698933 We demonstrate herein that , in contrast to alphabeta T cells , [TNF-alpha] production in Vgamma9Vdelta2 T lymphocytes is independent of CD28 costimulation and highly *dependent* on TcR induced p38 kinase and pathway activation for optimal cytokine release . Positive_regulation TNF MAPK1 10783388 707818 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Positive_regulation TNF MAPK1 10857765 704529 These findings indicate that beta2-adrenoceptor stimulation during an LPS challenge prevented [TNF-alpha] production as a *consequence* of inhibition and enhanced cAMP generation , which at a later stage was associated with an anti-inflammatory effect of IL-6 . Positive_regulation TNF MAPK1 11034403 740723 Although exogenous hsp27 stimulation activated all three monocyte mitogen activated protein kinase pathways ( extracellular signal related kinase ( ERK ) 1/2 , c-Jun N-terminal kinase , and p38 ) , only p38 activation was sustained and required for hsp27 induction of monocyte IL-10 , while both and p38 activation were *required* for induction of [TNF-alpha] when using the p38 inhibitor SB203580 or the ERK inhibitor PD98059 . Positive_regulation TNF MAPK1 11076936 786248 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Positive_regulation TNF MAPK1 11153597 761135 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as [tumour necrosis factor-alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) , in vitro and in vivo by inhibiting p38 . Positive_regulation TNF MAPK1 11221891 787427 Kinase suppressor of ras is necessary for [tumor necrosis factor] alpha *activation* of extracellular signal regulated in intestinal epithelial cells . Positive_regulation TNF MAPK1 11221891 787453 activity is *essential* for [tumor necrosis factor (TNF)] alpha receptor 1 regulation of intestinal epithelial cell proliferation . Positive_regulation TNF MAPK1 11278471 802555 [Tumor necrosis factor-alpha] induction of endothelial ephrin A1 expression is *mediated* by a p38 and SAPK/JNK dependent but nuclear factor-kappa B-independent mechanism . Positive_regulation TNF MAPK1 11299196 803161 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Positive_regulation TNF MAPK1 11443053 833722 Finally , PD-98059 , a p42/44 pathway inhibitor , *blocked* [TNF-alpha] upregulation by eNOS ( P = 0.02 ) . Positive_regulation TNF MAPK1 11443055 833736 p38 *mediates* renal tubular cell [TNF-alpha] production and TNF-alpha dependent apoptosis during simulated ischemia . Positive_regulation TNF MAPK1 11443055 833776 Furthermore , 60 min of ischemia induced renal tubular cell apoptosis at all substrate replacement time points examined , with peak apoptotic cell death occurring after either 24 or 48 h . p38 MAPK inhibition abolished [TNF-alpha] mRNA production and TNF-alpha bioactivity , and both p38 inhibition and TNF-alpha neutralization ( anti-porcine TNF-alpha antibody ) *prevented* apoptosis after 60 min of SI . Positive_regulation TNF MAPK1 11443055 833789 These results constitute the initial demonstration that 1 ) renal tubular cells produce TNF-alpha mRNA and biologically active [TNF-alpha] and undergo apoptosis in response to SI , and 2 ) p38 *mediates* renal tubular cell TNF-alpha production and TNF-alpha dependent apoptosis after SI . Positive_regulation TNF MAPK1 11675371 873172 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Positive_regulation TNF MAPK1 11689211 876143 [TNFalpha] *induced* activation in both cell types . Positive_regulation TNF MAPK1 11699878 878386 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Positive_regulation TNF MAPK1 11715476 581267 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Positive_regulation TNF MAPK1 11728947 884753 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Positive_regulation TNF MAPK1 11815388 907590 ( ERK ) blockade ( PD-98059 ) *attenuated* [TNF-alpha] secretion , an effect synergistically amplified in the presence of SB-203580 . Positive_regulation TNF MAPK1 11994432 938933 Evidence for a dual mechanism for IL-10 suppression of [TNF-alpha] production that does not *involve* inhibition of p38 or NF-kappa B in primary human macrophages . Positive_regulation TNF MAPK1 12130576 966545 Phosphorylation of p38 was *induced* by RANKL , IL-1 , [TNFalpha] , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation TNF MAPK1 12133965 967055 Selective inhibitors of ( PD98059 or U0126 ) , p38 ( SB203580 ) , or NF-kappa B ( caffeic acid phenetyl ester ( CAPE ) ) could all significantly *reduce* [TNF-alpha] production , although none of the inhibitors used alone was able to completely prevent TNF-alpha release . Positive_regulation TNF MAPK1 12391245 1007379 Release of [TNF-alpha] , macrophage-inflammatory protein (MIP)-2 ( MIP-1beta ) , and IL-8 by LPS stimulated neutrophils was also *reduced* by poststimulation p38 inhibition . Positive_regulation TNF MAPK1 12392277 1007658 Inhibition of p38 with SB203580 *inhibited* the production of [TNF-alpha] and IL-10 by LPS stimulated KCs , whereas blockade of ERK1/2 with PD98059 could reduce TNF-alpha production , but did not affect IL-10 production . Positive_regulation TNF MAPK1 12393915 1025397 This model probiotic also inhibits *activation* of the pro-apoptotic by [tumor necrosis factor] , interleukin-1alpha , or gamma-interferon . Positive_regulation TNF MAPK1 12438325 1016560 The activation of protein tyrosine kinases (PTK) and the serine/threonine kinases p38 and ERK was apparently *required* for MTSA-10 induction of [TNF-alpha] and NO release , as revealed by specific kinase inhibitors . Positive_regulation TNF MAPK1 12506117 1056924 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Positive_regulation TNF MAPK1 12526087 1028230 [TNF-alpha] does not *induce* phosphorylation of and S727 in ECV304 and smooth muscle cells . Positive_regulation TNF MAPK1 12631113 1067647 The present data indicate that [TNF-alpha] *activation* of PKCzeta/iota , p42/44 , c-Jun/AP-1 , and p65/NF-kappaB are involved in TNF-alpha stimulated MC fractalkine expression , with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro . Positive_regulation TNF MAPK1 12637577 1099250 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and [tumor necrosis factor alpha (TNFalpha)] *requires* p38 activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation TNF MAPK1 12694807 1080893 [TNF-alpha] *induced* the phosphorylation of p44/p42 and p38 MAP kinase . Positive_regulation TNF MAPK1 12734378 1087354 Our results indicate that A beta induced expression of cytokines ( [TNF-alpha] and IL-1 beta ) and chemokines ( MCP-1 , IL-8 , and MIP-1 beta ) in THP-1 monocytes *involves* activation of and downstream activation of Egr-1 . Positive_regulation TNF MAPK1 12881424 1116114 Importantly , [TNF] does not *induce* ROS accumulation or prolonged activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death Positive_regulation TNF MAPK1 12969251 1139147 Inhibition of the MAP-kinase-kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) pathway , but not that of ( MAPK-p38 ) , *reduced* NO , [TNF-alpha] and IL-6 significantly , suggesting that simultaneous activation of the first two pathways is necessary for the AGE induced induction of these pro-inflammatory stimuli . Positive_regulation TNF MAPK1 14654378 1176810 These findings suggest that the pre-ischemic *activation* of by [TNF] does not contribute to cardioprotection afforded by this agent . Positive_regulation TNF MAPK1 14980980 1220289 The selective p38 inhibitor , SB203580 , *inhibited* the promoter activities of iNOS and COX-2 rather than that of [TNF-alpha] . Positive_regulation TNF MAPK1 15027449 1222847 Apoptosis caused by chronic ethanol treatment may be due to ethanol potentiation of [TNF] *induced* activation of p38 . Positive_regulation TNF MAPK1 15100302 1239715 Previous studies have shown the mitogen activated protein kinases ( MAPKs ) to be activated in macrophages upon infection with Mycobacterium , and that expression of [TNF-alpha] and inducible NO synthase by infected macrophages was *dependent* on activation . Positive_regulation TNF MAPK1 15139014 1246940 The increase in [TNF-alpha] release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation TNF MAPK1 15233873 1269373 A. semen also inhibited the expression of [TNF-alpha] and the *activation* of , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation TNF MAPK1 15248214 1271204 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of [TNFalpha] and IL-1beta by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation TNF MAPK1 15302094 1283833 Selective p42/44 inhibitor could *reduce* the Pb- and LPS triggered [TNF-alpha] expression in U-373MG cells . Positive_regulation TNF MAPK1 15557189 1340406 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Positive_regulation TNF MAPK1 15557189 1340432 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Positive_regulation TNF MAPK1 15592496 1375211 Tenascin-W is found in malignant mammary tumors , promotes alpha8 integrin dependent motility and *requires* activity for BMP-2 and [TNF-alpha] induced expression in vitro . Positive_regulation TNF MAPK1 15614136 1357458 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Positive_regulation TNF MAPK1 15701814 1416523 p38 activation *leads* to increased production of [TNF-alpha] in ischemic injury and in macrophages . Positive_regulation TNF MAPK1 15701814 1416550 Inhibition of p38 activation *led* to inhibition of [TNF-alpha] production . Positive_regulation TNF MAPK1 15703956 1497450 *Activation* of p38 and phosphatidylinositol 3-kinase (PI3K) by [TNF-alpha] was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation TNF MAPK1 15833800 1425434 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Positive_regulation TNF MAPK1 15867183 1404197 In cultured cardiac myocytes , specific activation of stress activated , p38 , by upstream activator MKK6bE *led* to significant induction of [tumor necrosis factor-alpha] and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation TNF MAPK1 15893422 1419727 We also investigated whether specific inhibition of p38 and Erk1/2 would *inhibit* [TNF-alpha] and IL-6 production and thus astrocyte apoptosis , and proliferation , respectively . Positive_regulation TNF MAPK1 15893422 1419756 In contrast , inhibition of both p38 and significantly *diminished* [TNF-alpha] production , and totally abrogated production of this cytokine when both MAPK pathways were inhibited simultaneously . Positive_regulation TNF MAPK1 15925386 1440368 Our observations show that calcium , activation , HIF-1alpha , and NF-kappaB are *necessary* for ethanol induced [TNF-alpha] and TGF-beta1 expression . Positive_regulation TNF MAPK1 15979106 1459095 The involvement of this nucleoside in the *activation* of by [TNF-alpha] was also investigated . Positive_regulation TNF MAPK1 16051807 1438606 Specific inhibitors of p38 significantly *reduced* the H5N1/97 induced [TNF-alpha] expression in macrophages . Positive_regulation TNF MAPK1 16081599 1460332 These results indicate that gp120 elicited TNF-alpha production by macrophages involves chemokine receptor mediated PI-3K and MAPK activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and independently *regulate* [TNF-alpha] production . Positive_regulation TNF MAPK1 16271232 1479200 Similarly , the increased gene expression of proinflammatory cytokines [TNF-alpha] and IL-1beta in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation TNF MAPK1 16275991 1480265 Angiotensin II , [tumor necrosis factor-alpha] , or epidermal growth factor *induced* phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation TNF MAPK1 16291729 1526050 *Activation* of and Akt by anti-HER2/neu [ScFv-TNF-alpha] inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation TNF MAPK1 16403817 1540123 The [TNF] + dex stimulated increase in leptin was associated with an increase in p38 MAPK activity and was totally *blocked* by p38 inhibitors . Positive_regulation TNF MAPK1 16438946 1495424 Although gAd partially increased cAMP concentration and PKA activity , it directly reduced leptin induced ERK1/2 and p38 phosphorylation thus *inhibiting* [TNF-alpha] production . Positive_regulation TNF MAPK1 16480618 1496062 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Positive_regulation TNF MAPK1 16480618 1496101 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Positive_regulation TNF MAPK1 16517732 1530900 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of [TNF] , but not IL-6 , *requires* the activity of p38 . Positive_regulation TNF MAPK1 16573652 1556119 HA-mediated [TNF-alpha] production *required* p38 , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation TNF MAPK1 16581537 1543733 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Positive_regulation TNF MAPK1 16596287 1544879 These results collectively reveal that AV-ext *inhibits* [TNF-alpha] release from macrophages by suppressing and NF-kappaB signaling pathways and suggest that AV-ext may be beneficial for the treatment of endotoxin shock or sepsis . Positive_regulation TNF MAPK1 16771851 1572702 this process then leads to modulation of p38 *dependent* IL-8 and [TNF-alpha] release from the epithelium . Positive_regulation TNF MAPK1 16781693 1585598 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and [TNF-alpha] and the *activation* of 's are potentially positive signals for IL-10 production . Positive_regulation TNF MAPK1 16867160 1592831 Further , the activation of p38 and extracellular signal regulated kinase was *required* for the induction of [TNF-alpha] and IL-6 by MTB12 , as well as by the 30-kDa Ag . Positive_regulation TNF MAPK1 17032936 1692719 The stimulation of [TNF-alpha] production was *dependent* on cisplatin induced activation of p38 and was associated with phosphorylation of the translation initiation factor eIF4E and its upstream kinase Mnk1 . Positive_regulation TNF MAPK1 17032936 1692732 Inhibition of p38 and , to a lesser extent , ERK , *reduced* cisplatin+endotoxin stimulated [TNF-alpha] production and phosphorylation of Mnk1 and eIF4E . Positive_regulation TNF MAPK1 17074860 1675540 B. burgdorferi induced [TNF-alpha] production is also *dependent* on the activation of p38 . Positive_regulation TNF MAPK1 17117477 1677352 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Positive_regulation TNF MAPK1 17126905 1686512 Differential regulation of [TNFalpha] and GM-CSF *induced* activation of P38 in neutrophils and eosinophils . Positive_regulation TNF MAPK1 17131360 1700726 In addition , we recently found that p38 *mediates* [TNF-alpha] upregulation of atrogin-1/MAFbx expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation TNF MAPK1 17138860 1653555 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Positive_regulation TNF MAPK1 17172975 1679369 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK1 17172975 1679395 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK1 17202326 1680797 Augmented lipopolysaccharide induced [TNF-alpha] production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK1 17202326 1680823 In this study , we show that augmented LPS induced [TNF-alpha] production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK1 17395780 1766144 Here we demonstrate that Rab7b can negatively regulate lipopolysaccharide (LPS) induced production of [tumor necrosis factor (TNF)-alpha] , IL-6 , nitric oxide , and IFN-beta , and potentiate LPS induced *activation* of , nuclear factor kappaB , and IFN regulatory factor 3 signaling pathways in macrophages by promoting the degradation of TLR4 . Positive_regulation TNF MAPK1 17438131 1742738 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by [TNF-alpha] and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation TNF MAPK1 17553937 1791990 Twenty-four hours thereafter , splenic macrophages were isolated , and their IL-6 and [TNF-alpha] production and *activation* of and NF-kappaB were measured . Positive_regulation TNF MAPK1 17607712 1798170 Although [TNF] *induced* the activation of p38 , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation TNF MAPK1 17902045 1835071 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Positive_regulation TNF MAPK1 17934341 1813478 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Positive_regulation TNF MAPK1 17940160 1888978 Conversely , Ser phosphorylation of IRS-2 mediated by [TNF-alpha] *activation* of was the mechanism found in brown adipocytes . Positive_regulation TNF MAPK1 17964662 1831044 Taken together , these results suggest that linomide *inhibits* [TNF-alpha] production by suppressing the activation of NF-kappaB and , which might , at least in part , contribute to the beneficial effects of linomide in the treatment of autoimmune diseases . Positive_regulation TNF MAPK1 17994109 1851139 [TNF-alpha] triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation TNF MAPK1 18207479 1876664 [TNFalpha] signaling *involves* PI-3-kinase (PI3K)/protein kinase B (PKB) , and which are important in NF-kappaB activation . Positive_regulation TNF MAPK1 18227157 1884328 It was shown that these three proteins could ( i ) induce expression of [tumor necrosis factor alpha (TNF-alpha)] and tissue factor and ( ii ) *induce* phosphorylation of p44/42 and activation of early growth response factor 1 (Egr-1) . Positive_regulation TNF MAPK1 18296636 1878855 Whereas the induction of [TNFalpha] , IL-1beta , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation TNF MAPK1 18303184 1873518 Inhibition of p38 activation selectively *blocked* DNCB induced [TNF-alpha] release , but not NiSO ( 4 ) -induced release . Positive_regulation TNF MAPK1 18314537 1919428 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Positive_regulation TNF MAPK1 18390808 1925661 We tested the hypothesis that p38 activation is *necessary* for [TNF-alpha] production , neutrophil activation , and subsequent liver injury . Positive_regulation TNF MAPK1 18622138 1984353 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Positive_regulation TNF MAPK1 18675993 2011324 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Positive_regulation TNF MAPK1 19002259 1991226 Peptidoglycan stimulated monocyte p38 and p38 activity was *required* for [TNFalpha] production by the cells . Positive_regulation TNF MAPK1 19040616 2017402 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Positive_regulation TNF MAPK1 19043204 1998815 Moreover , [TNF-alpha] production was *prevented* by NF-kappaB and inhibitors . Positive_regulation TNF MAPK1 19052649 1999781 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Positive_regulation TNF MAPK1 19250666 2055372 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Positive_regulation TNF MAPK1 19267548 2045597 Since activated p38 *mediates* [TNF-alpha] production , we examined the effect of radiation on LPS induced activation of p38 MAPK and TNF-alpha production . Positive_regulation TNF MAPK1 19287189 2046599 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Positive_regulation TNF MAPK1 19351958 2088774 Specific inhibitors of p38 and glycogen synthase kinase 3 *suppressed* [TNF-alpha] production and maturation of fucoidan treated PBDCs . Positive_regulation TNF MAPK1 19427347 2106777 [TNF-alpha] *induced* the phosphorylation of p38 , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation TNF MAPK1 19477265 2107655 These results show that chronic ethanol feeding enhances Fas induced liver injury by a mechanism associated with induction of CYP2E1 , elevated serum [TNF-alpha] levels , and *activation* of . Positive_regulation TNF MAPK1 19493203 2091421 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Positive_regulation TNF MAPK1 19493203 2091447 In conclusion , our data indicate that signaling is *required* to induce maximal [TNF-alpha] production in macrophages during Orientia infection . Positive_regulation TNF MAPK1 19751557 2135271 p38MAPK 's phosphorylation is important in pathogenesis of MODS , and phosphorylation of can *enhance* TNF-alpha mRNA transcription and secretion of [TNF-alpha] from peripheral blood mononuclear cells , which is the mechanism of increased TNF-alpha in MODS . Positive_regulation TNF MAPK1 20010392 2175026 Because p38 ( p38 ) *upregulates* [TNF-alpha] expression and may play a crucial role in pain sensation , we investigated the effect of one injection of inhibitor on expression of the pain related neuropeptide calcitonin gene related peptide (CGRP) . Positive_regulation TNF MAPK1 20068037 2235126 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Positive_regulation TNF MAPK1 20083499 2380889 For the first time , we show that , in fish macrophages , [TNF-a] is processed by TACE-like activity and this cleavage is *dependent* upon the activation of ERK , and JNK signaling pathways by LPS . Positive_regulation TNF MAPK1 20499049 2276355 Expression of [TNF-alpha] and IL-6 in HMC-1 cells treated with bisphenol A is *attenuated* by plant originating glycoprotein ( 75 kDa ) by blocking p38 . Positive_regulation TNF MAPK1 20589681 2334359 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Positive_regulation TNF MAPK1 20646342 2292559 [TNF-alpha] *induced* a significant increase in p38 phosphorylation . Positive_regulation TNF MAPK1 20868379 2337164 [TNF-a] expression was *mediated* in a time dependent manner by p38 , activation of which is under the control of MKP1 . Positive_regulation TNF MAPK1 21208554 2374413 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Positive_regulation TNF MAPK1 21402598 2426923 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Positive_regulation TNF MAPK1 21545687 2554360 [Tumour necrosis factor-a (TNF-a)] significantly *induced* phosphorylation of p38 , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation TNF MAPK1 21642540 2446230 Pretreatment with TAT-SNAP-23 inhibited the increase in plasma membrane expression of gp91(phox) in TNF-a primed neutrophils , whereas [TNF-a] *activation* of ERK1/2 and p38 was not affected . Positive_regulation TNF MAPK1 21849907 2495987 All 3 inhibitors *suppressed* LPS induced [TNF-a] and I-309 expression in human primary monocytes . Positive_regulation TNF MAPK1 22002864 2526297 In this study , we found that inhibition of p38 with SB-203580 ( SB ) *reduced* H ( 2 ) O ( 2 ) -stimulated secretion of TNF-a , whereas pre-activation of p38 MAPK with sodium arsenite ( SA ) enhanced H ( 2 ) O ( 2 ) -stimulated secretion of [TNF-a] . Positive_regulation TNF MAPK1 22343222 2617756 Using immunohistological techniques , we showed a higher epithelial expression of [TNF-a] , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation TNF MAPK1 22385244 2566468 The use of selective inhibitors of signalling pathways revealed that induction of TG2 by IFN-? was mediated by phosphoinositide 3-kinase (PI3K) , while c-Jun N-terminal kinase (JNK) and p38 were *required* for [TNF-a] activation . Positive_regulation TNF MAPK1 22744777 2853442 After LPS administration , all animals displayed increased arterial carbon dioxide partial pressure ( PaCO2 ) and decreased arterial oxygen partial pressure ( PaO2 ) , arterial oxygen saturation ( SO2 ) , HCO3 ( - ) concentration and pH , and *increased* LWCI , MPO activity , interleukin (IL)-1ß , IL-6 and [tumor necrosis factor (TNF)-a] mRNA expression , NF-?B p65 positive staining and p38 activation compared with normal controls ( all P < 0.01 ) . Positive_regulation TNF MAPK1 23188524 2745405 We found that and Akt inhibitors , but not PI3K inhibitor , remarkably *suppressed* ACPA mediated [TNF-a] production . Positive_regulation TNF MAPK1 23354775 2769952 p38a may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , [tumor necrosis factor-a] , interleukin-1ß , and oxidative stress . Positive_regulation TNF MAPK1 23364439 2754519 Conversely , HTS activated p38 mitogen activated protein kinase (MAPK) and enhanced [TNF-a] *activation* of p38 . Positive_regulation TNF MAPK1 23557259 2777800 Inhibition of and CD137 signaling *reduce* dengue virus induced [TNF-a] secretion and apoptosis . Positive_regulation TNF MAPK1 23734186 2796923 Bla g 2 can stimulate up-regulation of inflammatory cytokines including [TNF-alpha] and IL-6 and *activation* of nuclear factor kappa B ( NF-kB/p65 ) , p38 ( p38 ) , ERK , and JNK in cultured fibrocytes . Positive_regulation TNF MAPK1 24089494 2848130 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed [TNF] receptor 1 and *requires* activation of p38 , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation TNF MAPK1 24441870 2922965 On the other hand , [TNF-a] could *induce* Akt and p42/p44 translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation TNF MAPK1 24750790 2936512 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas [TNFalpha] and NO production *required* all three . Positive_regulation TNF MAPK1 7722327 301740 [TNF-alpha] *induces* tyrosine phosphorylation of in adherent human neutrophils . Positive_regulation TNF MAPK1 7722327 301792 These results indicate that [TNF] signaling *involves* activation of . Positive_regulation TNF MAPK1 9120304 423857 Together , these results suggest that 1 ) the activation of MAPKs may play a role in Fc gammaR signal transduction , and 2 ) the activation of is *necessary* for Fc gamma R cross-linking induced [TNF-alpha] synthesis . Positive_regulation TNF MAPK1 9148963 430047 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Positive_regulation TNF MAPK1 9325311 456833 In trying to understand the mechanism of GPS2 activity , we found that it also suppressed [TNFalpha] *activation* of JNK1 but not TNFalpha activation of p38 kinase nor phorbol activation of . Positive_regulation TNF MAPK1 9418855 480524 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Positive_regulation TNF MAPK1 9439626 482878 These findings suggest a role for [TNF-alpha] in the regulation of intestinal epithelial cell growth and that the mitogenic effect of TNF-alpha *requires* protein tyrosine phosphorylation and activation . Positive_regulation TNF MAPK1 9530111 496718 *Activation* of in human umbilical vein endothelial cells by interleukin-1 alpha and [tumor necrosis factor-alpha] . Positive_regulation TNF MAPK1 9551930 499076 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , IL-1beta , and [TNF-alpha] , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation TNF MAPK1 9706151 526170 We hypothesized that hydrogen peroxide ( H2O2 ) induces myocardial dysfunction and cardiomyocyte death via P38 *mediated* myocardial [tumor necrosis factor (TNF)] production . Positive_regulation TNF MAPK1 9730957 530342 However , in contrast to the wild-type endotoxin , it failed to induce significant production of [tumor necrosis factor-alpha] and macrophage inflammatory protein-1alpha by monocytes and did not *induce* the phosphorylation and nuclear translocation of . Positive_regulation TNF MAPK1 9766635 538486 [TNF-alpha] and GM-CSF priming of superoxide release stimulated by N-formyl-methionyl-leucyl-phenylalanine was significantly *attenuated* by the MEK inhibitor , PD098059 , and the p38 inhibitor , SB203580 . Positive_regulation TNF MAPK1 9862693 556044 We have reported that phosphorylation and activation follows engagement of the low affinity receptor for the Fc portion of IgG ( CD16 ) on NK cells , and is *necessary* for CD16 induced [TNF-alpha] mRNA expression . Positive_regulation TNF MAPK1 9864164 582558 A selective p38 inhibitor , SB203580 , *blocked* [TNF] -- or ceramide induced CREB phosphorylation , but had no effect on the induction of apoptosis mediated by these agents . Positive_regulation TNF MAPK1 9864164 582639 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Positive_regulation TNF MAPK1 9883899 558191 *Activation* of p42/p44 mitogen activated protein kinases (MAPK) and p38 by [tumor necrosis factor (TNF)] is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation TNF MAPK10 10079106 595506 Specific inhibitors of p38alpha *blocked* LPS induced adhesion , nuclear factor-kappa B (NF-kappaB) activation , and synthesis of [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF MAPK10 10079106 595560 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Positive_regulation TNF MAPK10 10079106 595573 These findings support a pathway by which LPS stimulation of neutrophils results in activation of MKK3 , which in turn activates p38alpha , ultimately regulating adhesion , NF-kappaB activation , *enhanced* gene expression of [TNF-alpha] , and regulation of TNF-alpha synthesis . Positive_regulation TNF MAPK10 10210635 607636 ( 1 ) The human heart produces TNF-alpha after I/R , ( 2 ) p38 *mediates* myocardial I/R induced [TNF-alpha] production , ( 3 ) p38 MAPK inhibition limits functional impairment after I/R , and ( 4 ) inhibition of ischemia induced TNF-alpha production may represent a potent therapeutic strategy for improving myocardial function after angioplasty , coronary bypass , or heart transplantation . Positive_regulation TNF MAPK10 10329111 613024 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Positive_regulation TNF MAPK10 10521481 653035 Engagement of tumor necrosis factor (TNF) receptor 1 leads to ATF-2- and p38 *dependent* [TNF-alpha] gene expression . Positive_regulation TNF MAPK10 10521481 653093 The study presented here shows that autoregulation of [TNF-alpha] gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation TNF MAPK10 10586056 571699 Ligation of microglial CD40 results in p44/42 *dependent* [TNF-alpha] production that is opposed by TGF-beta 1 and IL-10 . Positive_regulation TNF MAPK10 10586056 571753 Inhibition of the upstream activator of p44/42 , mitogen activated protein/extracellular signal related kinase kinase 1/2 , with PD98059 , decreases phosphorylation of p44/42 MAPK and significantly *reduces* [TNF-alpha] release following ligation of microglial CD40 . Positive_regulation TNF MAPK10 10601128 574172 [Tumor necrosis factor-alpha (TNF-alpha)] alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation TNF MAPK10 10620700 657666 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Positive_regulation TNF MAPK10 10653605 663291 These results suggest that ( 1 ) while PTK and are *essential* for the production of [TNFalpha] , they are not necessary for the induction of MnSOD by LPS , and ( 2 ) while activation of NFkappaB alone is insufficient for the induction of TNFalpha mRNA by LPS , it is necessary for the induction of TNFalpha as well as MnSOD mRNAs . Positive_regulation TNF MAPK10 10655266 663523 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Positive_regulation TNF MAPK10 10657669 664186 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Positive_regulation TNF MAPK10 10669634 665791 In this study , we show that [TNF-alpha] *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation TNF MAPK10 10783388 707819 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Positive_regulation TNF MAPK10 10857765 704530 These findings indicate that beta2-adrenoceptor stimulation during an LPS challenge prevented [TNF-alpha] production as a *consequence* of inhibition and enhanced cAMP generation , which at a later stage was associated with an anti-inflammatory effect of IL-6 . Positive_regulation TNF MAPK10 11076936 786249 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Positive_regulation TNF MAPK10 11153597 761136 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as [tumour necrosis factor-alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) , in vitro and in vivo by inhibiting p38 . Positive_regulation TNF MAPK10 11221891 787428 Kinase suppressor of ras is necessary for [tumor necrosis factor] alpha *activation* of extracellular signal regulated in intestinal epithelial cells . Positive_regulation TNF MAPK10 11221891 787454 activity is *essential* for [tumor necrosis factor (TNF)] alpha receptor 1 regulation of intestinal epithelial cell proliferation . Positive_regulation TNF MAPK10 11278471 802556 [Tumor necrosis factor-alpha] induction of endothelial ephrin A1 expression is *mediated* by a p38 and SAPK/JNK dependent but nuclear factor-kappa B-independent mechanism . Positive_regulation TNF MAPK10 11299196 803162 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Positive_regulation TNF MAPK10 11443053 833723 Finally , PD-98059 , a p42/44 pathway inhibitor , *blocked* [TNF-alpha] upregulation by eNOS ( P = 0.02 ) . Positive_regulation TNF MAPK10 11443055 833737 p38 *mediates* renal tubular cell [TNF-alpha] production and TNF-alpha dependent apoptosis during simulated ischemia . Positive_regulation TNF MAPK10 11443055 833777 Furthermore , 60 min of ischemia induced renal tubular cell apoptosis at all substrate replacement time points examined , with peak apoptotic cell death occurring after either 24 or 48 h . p38 MAPK inhibition abolished [TNF-alpha] mRNA production and TNF-alpha bioactivity , and both p38 inhibition and TNF-alpha neutralization ( anti-porcine TNF-alpha antibody ) *prevented* apoptosis after 60 min of SI . Positive_regulation TNF MAPK10 11443055 833790 These results constitute the initial demonstration that 1 ) renal tubular cells produce TNF-alpha mRNA and biologically active [TNF-alpha] and undergo apoptosis in response to SI , and 2 ) p38 *mediates* renal tubular cell TNF-alpha production and TNF-alpha dependent apoptosis after SI . Positive_regulation TNF MAPK10 11675371 873173 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Positive_regulation TNF MAPK10 11699878 878387 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Positive_regulation TNF MAPK10 11715476 581268 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Positive_regulation TNF MAPK10 11728947 884754 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Positive_regulation TNF MAPK10 11815388 907591 ( ERK ) blockade ( PD-98059 ) *attenuated* [TNF-alpha] secretion , an effect synergistically amplified in the presence of SB-203580 . Positive_regulation TNF MAPK10 11994432 938934 Evidence for a dual mechanism for IL-10 suppression of [TNF-alpha] production that does not *involve* inhibition of p38 or NF-kappa B in primary human macrophages . Positive_regulation TNF MAPK10 12130576 966546 Phosphorylation of p38 was *induced* by RANKL , IL-1 , [TNFalpha] , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation TNF MAPK10 12391245 1007380 Release of [TNF-alpha] , macrophage-inflammatory protein (MIP)-2 ( MIP-1beta ) , and IL-8 by LPS stimulated neutrophils was also *reduced* by poststimulation p38 inhibition . Positive_regulation TNF MAPK10 12392277 1007659 Inhibition of p38 with SB203580 *inhibited* the production of [TNF-alpha] and IL-10 by LPS stimulated KCs , whereas blockade of ERK1/2 with PD98059 could reduce TNF-alpha production , but did not affect IL-10 production . Positive_regulation TNF MAPK10 12393915 1025398 This model probiotic also inhibits *activation* of the pro-apoptotic by [tumor necrosis factor] , interleukin-1alpha , or gamma-interferon . Positive_regulation TNF MAPK10 12438325 1016561 The activation of protein tyrosine kinases (PTK) and the serine/threonine kinases p38 and ERK was apparently *required* for MTSA-10 induction of [TNF-alpha] and NO release , as revealed by specific kinase inhibitors . Positive_regulation TNF MAPK10 12506117 1056925 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Positive_regulation TNF MAPK10 12631113 1067648 The present data indicate that [TNF-alpha] *activation* of PKCzeta/iota , p42/44 , c-Jun/AP-1 , and p65/NF-kappaB are involved in TNF-alpha stimulated MC fractalkine expression , with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro . Positive_regulation TNF MAPK10 12637577 1099251 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and [tumor necrosis factor alpha (TNFalpha)] *requires* p38 activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation TNF MAPK10 12694807 1080894 [TNF-alpha] *induced* the phosphorylation of p44/p42 and p38 MAP kinase . Positive_regulation TNF MAPK10 12881424 1116115 Importantly , [TNF] does not *induce* ROS accumulation or prolonged activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death Positive_regulation TNF MAPK10 12969251 1139148 Inhibition of the MAP-kinase-kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) pathway , but not that of ( MAPK-p38 ) , *reduced* NO , [TNF-alpha] and IL-6 significantly , suggesting that simultaneous activation of the first two pathways is necessary for the AGE induced induction of these pro-inflammatory stimuli . Positive_regulation TNF MAPK10 14654378 1176811 These findings suggest that the pre-ischemic *activation* of by [TNF] does not contribute to cardioprotection afforded by this agent . Positive_regulation TNF MAPK10 14980980 1220290 The selective p38 inhibitor , SB203580 , *inhibited* the promoter activities of iNOS and COX-2 rather than that of [TNF-alpha] . Positive_regulation TNF MAPK10 15027449 1222848 Apoptosis caused by chronic ethanol treatment may be due to ethanol potentiation of [TNF] *induced* activation of p38 . Positive_regulation TNF MAPK10 15100302 1239716 Previous studies have shown the mitogen activated protein kinases ( MAPKs ) to be activated in macrophages upon infection with Mycobacterium , and that expression of [TNF-alpha] and inducible NO synthase by infected macrophages was *dependent* on activation . Positive_regulation TNF MAPK10 15139014 1246941 The increase in [TNF-alpha] release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation TNF MAPK10 15233873 1269374 A. semen also inhibited the expression of [TNF-alpha] and the *activation* of , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation TNF MAPK10 15248214 1271205 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of [TNFalpha] and IL-1beta by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation TNF MAPK10 15302094 1283834 Selective p42/44 inhibitor could *reduce* the Pb- and LPS triggered [TNF-alpha] expression in U-373MG cells . Positive_regulation TNF MAPK10 15557189 1340407 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Positive_regulation TNF MAPK10 15557189 1340433 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Positive_regulation TNF MAPK10 15592496 1375212 Tenascin-W is found in malignant mammary tumors , promotes alpha8 integrin dependent motility and *requires* activity for BMP-2 and [TNF-alpha] induced expression in vitro . Positive_regulation TNF MAPK10 15614136 1357459 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Positive_regulation TNF MAPK10 15701814 1416524 p38 activation *leads* to increased production of [TNF-alpha] in ischemic injury and in macrophages . Positive_regulation TNF MAPK10 15701814 1416551 Inhibition of p38 activation *led* to inhibition of [TNF-alpha] production . Positive_regulation TNF MAPK10 15703956 1497451 *Activation* of p38 and phosphatidylinositol 3-kinase (PI3K) by [TNF-alpha] was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation TNF MAPK10 15833800 1425435 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Positive_regulation TNF MAPK10 15867183 1404198 In cultured cardiac myocytes , specific activation of stress activated , p38 , by upstream activator MKK6bE *led* to significant induction of [tumor necrosis factor-alpha] and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation TNF MAPK10 15893422 1419728 We also investigated whether specific inhibition of p38 and Erk1/2 would *inhibit* [TNF-alpha] and IL-6 production and thus astrocyte apoptosis , and proliferation , respectively . Positive_regulation TNF MAPK10 15925386 1440369 Our observations show that calcium , activation , HIF-1alpha , and NF-kappaB are *necessary* for ethanol induced [TNF-alpha] and TGF-beta1 expression . Positive_regulation TNF MAPK10 16051807 1438607 Specific inhibitors of p38 significantly *reduced* the H5N1/97 induced [TNF-alpha] expression in macrophages . Positive_regulation TNF MAPK10 16081599 1460333 These results indicate that gp120 elicited [TNF-alpha] production by macrophages *involves* chemokine receptor mediated PI-3K and activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and ERK-1/2 independently regulate TNF-alpha production . Positive_regulation TNF MAPK10 16271232 1479201 Similarly , the increased gene expression of proinflammatory cytokines [TNF-alpha] and IL-1beta in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation TNF MAPK10 16275991 1480266 Angiotensin II , [tumor necrosis factor-alpha] , or epidermal growth factor *induced* phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation TNF MAPK10 16291729 1526051 *Activation* of and Akt by anti-HER2/neu [ScFv-TNF-alpha] inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation TNF MAPK10 16403817 1540124 The [TNF] + dex stimulated increase in leptin was associated with an increase in p38 MAPK activity and was totally *blocked* by p38 inhibitors . Positive_regulation TNF MAPK10 16438946 1495425 Although gAd partially increased cAMP concentration and PKA activity , it directly reduced leptin induced ERK1/2 and p38 phosphorylation thus *inhibiting* [TNF-alpha] production . Positive_regulation TNF MAPK10 16480618 1496063 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Positive_regulation TNF MAPK10 16480618 1496102 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Positive_regulation TNF MAPK10 16517732 1530901 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of [TNF] , but not IL-6 , *requires* the activity of p38 . Positive_regulation TNF MAPK10 16573652 1556120 HA-mediated [TNF-alpha] production *required* p38 , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation TNF MAPK10 16581537 1543734 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Positive_regulation TNF MAPK10 16596287 1544880 These results collectively reveal that AV-ext *inhibits* [TNF-alpha] release from macrophages by suppressing and NF-kappaB signaling pathways and suggest that AV-ext may be beneficial for the treatment of endotoxin shock or sepsis . Positive_regulation TNF MAPK10 16771851 1572703 this process then leads to modulation of p38 *dependent* IL-8 and [TNF-alpha] release from the epithelium . Positive_regulation TNF MAPK10 16781693 1585599 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and [TNF-alpha] and the *activation* of 's are potentially positive signals for IL-10 production . Positive_regulation TNF MAPK10 16867160 1592832 Further , the activation of p38 and extracellular signal regulated kinase was *required* for the induction of [TNF-alpha] and IL-6 by MTB12 , as well as by the 30-kDa Ag . Positive_regulation TNF MAPK10 17032936 1692720 The stimulation of [TNF-alpha] production was *dependent* on cisplatin induced activation of p38 and was associated with phosphorylation of the translation initiation factor eIF4E and its upstream kinase Mnk1 . Positive_regulation TNF MAPK10 17032936 1692733 Inhibition of p38 and , to a lesser extent , ERK , *reduced* cisplatin+endotoxin stimulated [TNF-alpha] production and phosphorylation of Mnk1 and eIF4E . Positive_regulation TNF MAPK10 17074860 1675541 B. burgdorferi induced [TNF-alpha] production is also *dependent* on the activation of p38 . Positive_regulation TNF MAPK10 17117477 1677353 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Positive_regulation TNF MAPK10 17126905 1686513 Differential regulation of [TNFalpha] and GM-CSF *induced* activation of P38 in neutrophils and eosinophils . Positive_regulation TNF MAPK10 17131360 1700727 In addition , we recently found that p38 *mediates* [TNF-alpha] upregulation of atrogin-1/MAFbx expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation TNF MAPK10 17138860 1653556 The purpose of this study was to determine whether the , ERK1/2 , and p38 MAPK are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Positive_regulation TNF MAPK10 17172975 1679370 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK10 17172975 1679396 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK10 17202326 1680798 Augmented lipopolysaccharide induced [TNF-alpha] production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK10 17202326 1680824 In this study , we show that augmented LPS induced [TNF-alpha] production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK10 17395780 1766145 Here we demonstrate that Rab7b can negatively regulate lipopolysaccharide (LPS) induced production of [tumor necrosis factor (TNF)-alpha] , IL-6 , nitric oxide , and IFN-beta , and potentiate LPS induced *activation* of , nuclear factor kappaB , and IFN regulatory factor 3 signaling pathways in macrophages by promoting the degradation of TLR4 . Positive_regulation TNF MAPK10 17438131 1742739 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by [TNF-alpha] and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation TNF MAPK10 17553937 1791991 Twenty-four hours thereafter , splenic macrophages were isolated , and their IL-6 and [TNF-alpha] production and *activation* of and NF-kappaB were measured . Positive_regulation TNF MAPK10 17607712 1798171 Although [TNF] *induced* the activation of p38 , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation TNF MAPK10 17902045 1835072 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Positive_regulation TNF MAPK10 17934341 1813479 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Positive_regulation TNF MAPK10 17940160 1888979 Conversely , Ser phosphorylation of IRS-2 mediated by [TNF-alpha] *activation* of was the mechanism found in brown adipocytes . Positive_regulation TNF MAPK10 17964662 1831045 Taken together , these results suggest that linomide *inhibits* [TNF-alpha] production by suppressing the activation of NF-kappaB and , which might , at least in part , contribute to the beneficial effects of linomide in the treatment of autoimmune diseases . Positive_regulation TNF MAPK10 17994109 1851140 [TNF-alpha] triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation TNF MAPK10 18227157 1884329 It was shown that these three proteins could ( i ) induce expression of [tumor necrosis factor alpha (TNF-alpha)] and tissue factor and ( ii ) *induce* phosphorylation of p44/42 and activation of early growth response factor 1 (Egr-1) . Positive_regulation TNF MAPK10 18296636 1878856 Whereas the induction of [TNFalpha] , IL-1beta , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation TNF MAPK10 18303184 1873519 Inhibition of p38 activation selectively *blocked* DNCB induced [TNF-alpha] release , but not NiSO ( 4 ) -induced release . Positive_regulation TNF MAPK10 18314537 1919429 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Positive_regulation TNF MAPK10 18390808 1925662 We tested the hypothesis that p38 activation is *necessary* for [TNF-alpha] production , neutrophil activation , and subsequent liver injury . Positive_regulation TNF MAPK10 18622138 1984354 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Positive_regulation TNF MAPK10 18675993 2011325 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Positive_regulation TNF MAPK10 19002259 1991227 Peptidoglycan stimulated monocyte p38 and p38 activity was *required* for [TNFalpha] production by the cells . Positive_regulation TNF MAPK10 19040616 2017403 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Positive_regulation TNF MAPK10 19043204 1998816 Moreover , [TNF-alpha] production was *prevented* by NF-kappaB and inhibitors . Positive_regulation TNF MAPK10 19052649 1999782 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Positive_regulation TNF MAPK10 19250666 2055373 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Positive_regulation TNF MAPK10 19267548 2045598 Since activated p38 *mediates* [TNF-alpha] production , we examined the effect of radiation on LPS induced activation of p38 MAPK and TNF-alpha production . Positive_regulation TNF MAPK10 19287189 2046600 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Positive_regulation TNF MAPK10 19351958 2088775 Specific inhibitors of p38 and glycogen synthase kinase 3 *suppressed* [TNF-alpha] production and maturation of fucoidan treated PBDCs . Positive_regulation TNF MAPK10 19427347 2106778 [TNF-alpha] *induced* the phosphorylation of p38 , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation TNF MAPK10 19477265 2107656 These results show that chronic ethanol feeding enhances Fas induced liver injury by a mechanism associated with induction of CYP2E1 , elevated serum [TNF-alpha] levels , and *activation* of . Positive_regulation TNF MAPK10 19493203 2091422 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Positive_regulation TNF MAPK10 19493203 2091448 In conclusion , our data indicate that signaling is *required* to induce maximal [TNF-alpha] production in macrophages during Orientia infection . Positive_regulation TNF MAPK10 19751557 2135272 p38MAPK 's phosphorylation is important in pathogenesis of MODS , and phosphorylation of can *enhance* TNF-alpha mRNA transcription and secretion of [TNF-alpha] from peripheral blood mononuclear cells , which is the mechanism of increased TNF-alpha in MODS . Positive_regulation TNF MAPK10 20010392 2175027 Because p38 ( p38 ) *upregulates* [TNF-alpha] expression and may play a crucial role in pain sensation , we investigated the effect of one injection of inhibitor on expression of the pain related neuropeptide calcitonin gene related peptide (CGRP) . Positive_regulation TNF MAPK10 20068037 2235127 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Positive_regulation TNF MAPK10 20083499 2380890 For the first time , we show that , in fish macrophages , [TNF-a] is processed by TACE-like activity and this cleavage is *dependent* upon the activation of ERK , and JNK signaling pathways by LPS . Positive_regulation TNF MAPK10 20499049 2276356 Expression of [TNF-alpha] and IL-6 in HMC-1 cells treated with bisphenol A is *attenuated* by plant originating glycoprotein ( 75 kDa ) by blocking p38 . Positive_regulation TNF MAPK10 20552320 2181572 Dominant negative JNK1 inhibited TNF-alpha- or etoposide induced apoptosis , while dominant negative *promoted* [TNF-alpha-] or etoposide induced apoptosis . Positive_regulation TNF MAPK10 20589681 2334360 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Positive_regulation TNF MAPK10 20646342 2292560 [TNF-alpha] *induced* a significant increase in p38 phosphorylation . Positive_regulation TNF MAPK10 20868379 2337165 [TNF-a] expression was *mediated* in a time dependent manner by p38 , activation of which is under the control of MKP1 . Positive_regulation TNF MAPK10 21208554 2374414 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Positive_regulation TNF MAPK10 21402598 2426924 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Positive_regulation TNF MAPK10 21545687 2554361 [Tumour necrosis factor-a (TNF-a)] significantly *induced* phosphorylation of p38 , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation TNF MAPK10 21642540 2446231 Pretreatment with TAT-SNAP-23 inhibited the increase in plasma membrane expression of gp91(phox) in TNF-a primed neutrophils , whereas [TNF-a] *activation* of ERK1/2 and p38 was not affected . Positive_regulation TNF MAPK10 21849907 2495988 All 3 inhibitors *suppressed* LPS induced [TNF-a] and I-309 expression in human primary monocytes . Positive_regulation TNF MAPK10 22002864 2526298 In this study , we found that inhibition of p38 with SB-203580 ( SB ) *reduced* H ( 2 ) O ( 2 ) -stimulated secretion of [TNF-a] , whereas pre-activation of p38 MAPK with sodium arsenite ( SA ) enhanced H ( 2 ) O ( 2 ) -stimulated secretion of TNF-a . Positive_regulation TNF MAPK10 22343222 2617757 Using immunohistological techniques , we showed a higher epithelial expression of [TNF-a] , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation TNF MAPK10 22385244 2566469 The use of selective inhibitors of signalling pathways revealed that induction of TG2 by IFN-? was mediated by phosphoinositide 3-kinase (PI3K) , while c-Jun N-terminal kinase (JNK) and p38 were *required* for [TNF-a] activation . Positive_regulation TNF MAPK10 22744777 2853443 After LPS administration , all animals displayed increased arterial carbon dioxide partial pressure ( PaCO2 ) and decreased arterial oxygen partial pressure ( PaO2 ) , arterial oxygen saturation ( SO2 ) , HCO3 ( - ) concentration and pH , and *increased* LWCI , MPO activity , interleukin (IL)-1ß , IL-6 and [tumor necrosis factor (TNF)-a] mRNA expression , NF-?B p65 positive staining and p38 activation compared with normal controls ( all P < 0.01 ) . Positive_regulation TNF MAPK10 23188524 2745406 We found that and Akt inhibitors , but not PI3K inhibitor , remarkably *suppressed* ACPA mediated [TNF-a] production . Positive_regulation TNF MAPK10 23354775 2769953 p38a may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , [tumor necrosis factor-a] , interleukin-1ß , and oxidative stress . Positive_regulation TNF MAPK10 23364439 2754520 Conversely , HTS activated p38 mitogen activated protein kinase (MAPK) and enhanced [TNF-a] *activation* of p38 . Positive_regulation TNF MAPK10 23557259 2777801 Inhibition of and CD137 signaling *reduce* dengue virus induced [TNF-a] secretion and apoptosis . Positive_regulation TNF MAPK10 23734186 2796924 Bla g 2 can stimulate up-regulation of inflammatory cytokines including [TNF-alpha] and IL-6 and *activation* of nuclear factor kappa B ( NF-kB/p65 ) , p38 ( p38 ) , ERK , and JNK in cultured fibrocytes . Positive_regulation TNF MAPK10 24089494 2848131 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed [TNF] receptor 1 and *requires* activation of p38 , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation TNF MAPK10 24441870 2922966 On the other hand , [TNF-a] could *induce* Akt and p42/p44 translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation TNF MAPK10 24750790 2936513 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas [TNFalpha] and NO production *required* all three . Positive_regulation TNF MAPK10 7722327 301741 [TNF-alpha] *induces* tyrosine phosphorylation of in adherent human neutrophils . Positive_regulation TNF MAPK10 7722327 301793 These results indicate that [TNF] signaling *involves* activation of . Positive_regulation TNF MAPK10 9148963 430048 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Positive_regulation TNF MAPK10 9418855 480525 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Positive_regulation TNF MAPK10 9439626 482879 These findings suggest a role for [TNF-alpha] in the regulation of intestinal epithelial cell growth and that the mitogenic effect of TNF-alpha *requires* protein tyrosine phosphorylation and activation . Positive_regulation TNF MAPK10 9551930 499077 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , IL-1beta , and [TNF-alpha] , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation TNF MAPK10 9706151 526171 We hypothesized that hydrogen peroxide ( H2O2 ) induces myocardial dysfunction and cardiomyocyte death via P38 *mediated* myocardial [tumor necrosis factor (TNF)] production . Positive_regulation TNF MAPK10 9730957 530343 However , in contrast to the wild-type endotoxin , it failed to induce significant production of [tumor necrosis factor-alpha] and macrophage inflammatory protein-1alpha by monocytes and did not *induce* the phosphorylation and nuclear translocation of . Positive_regulation TNF MAPK10 9766635 538487 [TNF-alpha] and GM-CSF priming of superoxide release stimulated by N-formyl-methionyl-leucyl-phenylalanine was significantly *attenuated* by the MEK inhibitor , PD098059 , and the p38 inhibitor , SB203580 . Positive_regulation TNF MAPK10 9864164 582559 A selective p38 inhibitor , SB203580 , *blocked* [TNF] -- or ceramide induced CREB phosphorylation , but had no effect on the induction of apoptosis mediated by these agents . Positive_regulation TNF MAPK10 9864164 582640 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Positive_regulation TNF MAPK10 9883899 558192 *Activation* of p42/p44 and p38 MAPK by [tumor necrosis factor (TNF)] is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation TNF MAPK11 10079106 595507 Specific inhibitors of p38alpha *blocked* LPS induced adhesion , nuclear factor-kappa B (NF-kappaB) activation , and synthesis of [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF MAPK11 10079106 595561 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Positive_regulation TNF MAPK11 10079106 595574 These findings support a pathway by which LPS stimulation of neutrophils results in activation of MKK3 , which in turn activates p38alpha , ultimately regulating adhesion , NF-kappaB activation , *enhanced* gene expression of [TNF-alpha] , and regulation of TNF-alpha synthesis . Positive_regulation TNF MAPK11 10210635 607637 ( 1 ) The human heart produces TNF-alpha after I/R , ( 2 ) p38 *mediates* myocardial I/R induced [TNF-alpha] production , ( 3 ) p38 MAPK inhibition limits functional impairment after I/R , and ( 4 ) inhibition of ischemia induced TNF-alpha production may represent a potent therapeutic strategy for improving myocardial function after angioplasty , coronary bypass , or heart transplantation . Positive_regulation TNF MAPK11 10329111 613025 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Positive_regulation TNF MAPK11 10521481 653036 Engagement of tumor necrosis factor (TNF) receptor 1 leads to ATF-2- and p38 *dependent* [TNF-alpha] gene expression . Positive_regulation TNF MAPK11 10521481 653094 The study presented here shows that autoregulation of [TNF-alpha] gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation TNF MAPK11 10586056 571700 Ligation of microglial CD40 results in p44/42 *dependent* [TNF-alpha] production that is opposed by TGF-beta 1 and IL-10 . Positive_regulation TNF MAPK11 10586056 571754 Inhibition of the upstream activator of p44/42 , mitogen activated protein/extracellular signal related kinase kinase 1/2 , with PD98059 , decreases phosphorylation of p44/42 MAPK and significantly *reduces* [TNF-alpha] release following ligation of microglial CD40 . Positive_regulation TNF MAPK11 10601128 574173 [Tumor necrosis factor-alpha (TNF-alpha)] alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation TNF MAPK11 10620700 657667 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Positive_regulation TNF MAPK11 10653605 663292 These results suggest that ( 1 ) while PTK and are *essential* for the production of [TNFalpha] , they are not necessary for the induction of MnSOD by LPS , and ( 2 ) while activation of NFkappaB alone is insufficient for the induction of TNFalpha mRNA by LPS , it is necessary for the induction of TNFalpha as well as MnSOD mRNAs . Positive_regulation TNF MAPK11 10655266 663524 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Positive_regulation TNF MAPK11 10657669 664187 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Positive_regulation TNF MAPK11 10669634 665792 In this study , we show that [TNF-alpha] *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation TNF MAPK11 10783388 707820 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Positive_regulation TNF MAPK11 10857765 704531 These findings indicate that beta2-adrenoceptor stimulation during an LPS challenge prevented [TNF-alpha] production as a *consequence* of inhibition and enhanced cAMP generation , which at a later stage was associated with an anti-inflammatory effect of IL-6 . Positive_regulation TNF MAPK11 11076936 786250 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Positive_regulation TNF MAPK11 11153597 761137 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as [tumour necrosis factor-alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) , in vitro and in vivo by inhibiting p38 . Positive_regulation TNF MAPK11 11221891 787429 Kinase suppressor of ras is necessary for [tumor necrosis factor] alpha *activation* of extracellular signal regulated in intestinal epithelial cells . Positive_regulation TNF MAPK11 11221891 787455 activity is *essential* for [tumor necrosis factor (TNF)] alpha receptor 1 regulation of intestinal epithelial cell proliferation . Positive_regulation TNF MAPK11 11278471 802557 [Tumor necrosis factor-alpha] induction of endothelial ephrin A1 expression is *mediated* by a p38 and SAPK/JNK dependent but nuclear factor-kappa B-independent mechanism . Positive_regulation TNF MAPK11 11299196 803163 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Positive_regulation TNF MAPK11 11443053 833724 Finally , PD-98059 , a p42/44 pathway inhibitor , *blocked* [TNF-alpha] upregulation by eNOS ( P = 0.02 ) . Positive_regulation TNF MAPK11 11443055 833738 p38 *mediates* renal tubular cell [TNF-alpha] production and TNF-alpha dependent apoptosis during simulated ischemia . Positive_regulation TNF MAPK11 11443055 833778 Furthermore , 60 min of ischemia induced renal tubular cell apoptosis at all substrate replacement time points examined , with peak apoptotic cell death occurring after either 24 or 48 h . p38 MAPK inhibition abolished [TNF-alpha] mRNA production and TNF-alpha bioactivity , and both p38 inhibition and TNF-alpha neutralization ( anti-porcine TNF-alpha antibody ) *prevented* apoptosis after 60 min of SI . Positive_regulation TNF MAPK11 11443055 833791 These results constitute the initial demonstration that 1 ) renal tubular cells produce TNF-alpha mRNA and biologically active [TNF-alpha] and undergo apoptosis in response to SI , and 2 ) p38 *mediates* renal tubular cell TNF-alpha production and TNF-alpha dependent apoptosis after SI . Positive_regulation TNF MAPK11 11675371 873174 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Positive_regulation TNF MAPK11 11699878 878388 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Positive_regulation TNF MAPK11 11715476 581269 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Positive_regulation TNF MAPK11 11728947 884755 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Positive_regulation TNF MAPK11 11815388 907592 ( ERK ) blockade ( PD-98059 ) *attenuated* [TNF-alpha] secretion , an effect synergistically amplified in the presence of SB-203580 . Positive_regulation TNF MAPK11 11994432 938935 Evidence for a dual mechanism for IL-10 suppression of [TNF-alpha] production that does not *involve* inhibition of p38 or NF-kappa B in primary human macrophages . Positive_regulation TNF MAPK11 12130576 966547 Phosphorylation of p38 was *induced* by RANKL , IL-1 , [TNFalpha] , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation TNF MAPK11 12391245 1007381 Release of [TNF-alpha] , macrophage-inflammatory protein (MIP)-2 ( MIP-1beta ) , and IL-8 by LPS stimulated neutrophils was also *reduced* by poststimulation p38 inhibition . Positive_regulation TNF MAPK11 12392277 1007660 Inhibition of p38 with SB203580 *inhibited* the production of [TNF-alpha] and IL-10 by LPS stimulated KCs , whereas blockade of ERK1/2 with PD98059 could reduce TNF-alpha production , but did not affect IL-10 production . Positive_regulation TNF MAPK11 12393915 1025399 This model probiotic also inhibits *activation* of the pro-apoptotic by [tumor necrosis factor] , interleukin-1alpha , or gamma-interferon . Positive_regulation TNF MAPK11 12438325 1016562 The activation of protein tyrosine kinases (PTK) and the serine/threonine kinases p38 and ERK was apparently *required* for MTSA-10 induction of [TNF-alpha] and NO release , as revealed by specific kinase inhibitors . Positive_regulation TNF MAPK11 12506117 1056926 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Positive_regulation TNF MAPK11 12631113 1067649 The present data indicate that [TNF-alpha] *activation* of PKCzeta/iota , p42/44 , c-Jun/AP-1 , and p65/NF-kappaB are involved in TNF-alpha stimulated MC fractalkine expression , with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro . Positive_regulation TNF MAPK11 12637577 1099252 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and [tumor necrosis factor alpha (TNFalpha)] *requires* p38 activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation TNF MAPK11 12694807 1080895 [TNF-alpha] *induced* the phosphorylation of p44/p42 and p38 MAP kinase . Positive_regulation TNF MAPK11 12881424 1116116 Importantly , [TNF] does not *induce* ROS accumulation or prolonged activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death Positive_regulation TNF MAPK11 12969251 1139149 Inhibition of the MAP-kinase-kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) pathway , but not that of ( MAPK-p38 ) , *reduced* NO , [TNF-alpha] and IL-6 significantly , suggesting that simultaneous activation of the first two pathways is necessary for the AGE induced induction of these pro-inflammatory stimuli . Positive_regulation TNF MAPK11 14654378 1176812 These findings suggest that the pre-ischemic *activation* of by [TNF] does not contribute to cardioprotection afforded by this agent . Positive_regulation TNF MAPK11 14980980 1220291 The selective p38 inhibitor , SB203580 , *inhibited* the promoter activities of iNOS and COX-2 rather than that of [TNF-alpha] . Positive_regulation TNF MAPK11 15027449 1222849 Apoptosis caused by chronic ethanol treatment may be due to ethanol potentiation of [TNF] *induced* activation of p38 . Positive_regulation TNF MAPK11 15100302 1239717 Previous studies have shown the mitogen activated protein kinases ( MAPKs ) to be activated in macrophages upon infection with Mycobacterium , and that expression of [TNF-alpha] and inducible NO synthase by infected macrophages was *dependent* on activation . Positive_regulation TNF MAPK11 15139014 1246942 The increase in [TNF-alpha] release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation TNF MAPK11 15233873 1269375 A. semen also inhibited the expression of [TNF-alpha] and the *activation* of , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation TNF MAPK11 15248214 1271206 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of [TNFalpha] and IL-1beta by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation TNF MAPK11 15302094 1283835 Selective p42/44 inhibitor could *reduce* the Pb- and LPS triggered [TNF-alpha] expression in U-373MG cells . Positive_regulation TNF MAPK11 15557189 1340408 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Positive_regulation TNF MAPK11 15557189 1340434 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Positive_regulation TNF MAPK11 15592496 1375213 Tenascin-W is found in malignant mammary tumors , promotes alpha8 integrin dependent motility and *requires* activity for BMP-2 and [TNF-alpha] induced expression in vitro . Positive_regulation TNF MAPK11 15614136 1357460 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Positive_regulation TNF MAPK11 15701814 1416525 p38 activation *leads* to increased production of [TNF-alpha] in ischemic injury and in macrophages . Positive_regulation TNF MAPK11 15701814 1416552 Inhibition of p38 activation *led* to inhibition of [TNF-alpha] production . Positive_regulation TNF MAPK11 15703956 1497452 *Activation* of p38 and phosphatidylinositol 3-kinase (PI3K) by [TNF-alpha] was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation TNF MAPK11 15833800 1425436 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Positive_regulation TNF MAPK11 15867183 1404199 In cultured cardiac myocytes , specific activation of stress activated , p38 , by upstream activator MKK6bE *led* to significant induction of [tumor necrosis factor-alpha] and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation TNF MAPK11 15893422 1419729 We also investigated whether specific inhibition of p38 and Erk1/2 would *inhibit* [TNF-alpha] and IL-6 production and thus astrocyte apoptosis , and proliferation , respectively . Positive_regulation TNF MAPK11 15925386 1440370 Our observations show that calcium , activation , HIF-1alpha , and NF-kappaB are *necessary* for ethanol induced [TNF-alpha] and TGF-beta1 expression . Positive_regulation TNF MAPK11 16051807 1438608 Specific inhibitors of p38 significantly *reduced* the H5N1/97 induced [TNF-alpha] expression in macrophages . Positive_regulation TNF MAPK11 16081599 1460334 These results indicate that gp120 elicited [TNF-alpha] production by macrophages *involves* chemokine receptor mediated PI-3K and activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and ERK-1/2 independently regulate TNF-alpha production . Positive_regulation TNF MAPK11 16271232 1479202 Similarly , the increased gene expression of proinflammatory cytokines [TNF-alpha] and IL-1beta in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation TNF MAPK11 16275991 1480267 Angiotensin II , [tumor necrosis factor-alpha] , or epidermal growth factor *induced* phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation TNF MAPK11 16291729 1526052 *Activation* of and Akt by anti-HER2/neu [ScFv-TNF-alpha] inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation TNF MAPK11 16403817 1540125 The [TNF] + dex stimulated increase in leptin was associated with an increase in p38 MAPK activity and was totally *blocked* by p38 inhibitors . Positive_regulation TNF MAPK11 16438946 1495426 Although gAd partially increased cAMP concentration and PKA activity , it directly reduced leptin induced ERK1/2 and p38 phosphorylation thus *inhibiting* [TNF-alpha] production . Positive_regulation TNF MAPK11 16480618 1496064 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Positive_regulation TNF MAPK11 16480618 1496103 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Positive_regulation TNF MAPK11 16517732 1530902 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of [TNF] , but not IL-6 , *requires* the activity of p38 . Positive_regulation TNF MAPK11 16573652 1556121 HA-mediated [TNF-alpha] production *required* p38 , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation TNF MAPK11 16581537 1543735 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Positive_regulation TNF MAPK11 16596287 1544881 These results collectively reveal that AV-ext *inhibits* [TNF-alpha] release from macrophages by suppressing and NF-kappaB signaling pathways and suggest that AV-ext may be beneficial for the treatment of endotoxin shock or sepsis . Positive_regulation TNF MAPK11 16771851 1572704 this process then leads to modulation of p38 *dependent* IL-8 and [TNF-alpha] release from the epithelium . Positive_regulation TNF MAPK11 16781693 1585600 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and [TNF-alpha] and the *activation* of 's are potentially positive signals for IL-10 production . Positive_regulation TNF MAPK11 16867160 1592833 Further , the activation of p38 and extracellular signal regulated kinase was *required* for the induction of [TNF-alpha] and IL-6 by MTB12 , as well as by the 30-kDa Ag . Positive_regulation TNF MAPK11 17032936 1692721 The stimulation of [TNF-alpha] production was *dependent* on cisplatin induced activation of p38 and was associated with phosphorylation of the translation initiation factor eIF4E and its upstream kinase Mnk1 . Positive_regulation TNF MAPK11 17032936 1692734 Inhibition of p38 and , to a lesser extent , ERK , *reduced* cisplatin+endotoxin stimulated [TNF-alpha] production and phosphorylation of Mnk1 and eIF4E . Positive_regulation TNF MAPK11 17074860 1675542 B. burgdorferi induced [TNF-alpha] production is also *dependent* on the activation of p38 . Positive_regulation TNF MAPK11 17117477 1677354 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Positive_regulation TNF MAPK11 17126905 1686514 Differential regulation of [TNFalpha] and GM-CSF *induced* activation of P38 in neutrophils and eosinophils . Positive_regulation TNF MAPK11 17131360 1700728 In addition , we recently found that p38 *mediates* [TNF-alpha] upregulation of atrogin-1/MAFbx expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation TNF MAPK11 17138860 1653557 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Positive_regulation TNF MAPK11 17172975 1679371 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK11 17172975 1679397 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK11 17202326 1680799 Augmented lipopolysaccharide induced [TNF-alpha] production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK11 17202326 1680825 In this study , we show that augmented LPS induced [TNF-alpha] production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK11 17395780 1766146 Here we demonstrate that Rab7b can negatively regulate lipopolysaccharide (LPS) induced production of [tumor necrosis factor (TNF)-alpha] , IL-6 , nitric oxide , and IFN-beta , and potentiate LPS induced *activation* of , nuclear factor kappaB , and IFN regulatory factor 3 signaling pathways in macrophages by promoting the degradation of TLR4 . Positive_regulation TNF MAPK11 17438131 1742740 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by [TNF-alpha] and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation TNF MAPK11 17553937 1791992 Twenty-four hours thereafter , splenic macrophages were isolated , and their IL-6 and [TNF-alpha] production and *activation* of and NF-kappaB were measured . Positive_regulation TNF MAPK11 17607712 1798172 Although [TNF] *induced* the activation of p38 , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation TNF MAPK11 17902045 1835073 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Positive_regulation TNF MAPK11 17934341 1813480 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Positive_regulation TNF MAPK11 17940160 1888980 Conversely , Ser phosphorylation of IRS-2 mediated by [TNF-alpha] *activation* of was the mechanism found in brown adipocytes . Positive_regulation TNF MAPK11 17964662 1831046 Taken together , these results suggest that linomide *inhibits* [TNF-alpha] production by suppressing the activation of NF-kappaB and , which might , at least in part , contribute to the beneficial effects of linomide in the treatment of autoimmune diseases . Positive_regulation TNF MAPK11 17994109 1851141 [TNF-alpha] triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation TNF MAPK11 18227157 1884330 It was shown that these three proteins could ( i ) induce expression of [tumor necrosis factor alpha (TNF-alpha)] and tissue factor and ( ii ) *induce* phosphorylation of p44/42 and activation of early growth response factor 1 (Egr-1) . Positive_regulation TNF MAPK11 18296636 1878857 Whereas the induction of [TNFalpha] , IL-1beta , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation TNF MAPK11 18303184 1873520 Inhibition of p38 activation selectively *blocked* DNCB induced [TNF-alpha] release , but not NiSO ( 4 ) -induced release . Positive_regulation TNF MAPK11 18314537 1919430 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Positive_regulation TNF MAPK11 18390808 1925663 We tested the hypothesis that p38 activation is *necessary* for [TNF-alpha] production , neutrophil activation , and subsequent liver injury . Positive_regulation TNF MAPK11 18622138 1984355 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Positive_regulation TNF MAPK11 18675993 2011326 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Positive_regulation TNF MAPK11 19002259 1991228 Peptidoglycan stimulated monocyte p38 and p38 activity was *required* for [TNFalpha] production by the cells . Positive_regulation TNF MAPK11 19040616 2017404 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Positive_regulation TNF MAPK11 19043204 1998817 Moreover , [TNF-alpha] production was *prevented* by NF-kappaB and inhibitors . Positive_regulation TNF MAPK11 19052649 1999783 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Positive_regulation TNF MAPK11 19250666 2055374 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Positive_regulation TNF MAPK11 19267548 2045599 Since activated p38 *mediates* [TNF-alpha] production , we examined the effect of radiation on LPS induced activation of p38 MAPK and TNF-alpha production . Positive_regulation TNF MAPK11 19287189 2046601 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Positive_regulation TNF MAPK11 19351958 2088776 Specific inhibitors of p38 and glycogen synthase kinase 3 *suppressed* [TNF-alpha] production and maturation of fucoidan treated PBDCs . Positive_regulation TNF MAPK11 19427347 2106779 [TNF-alpha] *induced* the phosphorylation of p38 , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation TNF MAPK11 19477265 2107657 These results show that chronic ethanol feeding enhances Fas induced liver injury by a mechanism associated with induction of CYP2E1 , elevated serum [TNF-alpha] levels , and *activation* of . Positive_regulation TNF MAPK11 19493203 2091423 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Positive_regulation TNF MAPK11 19493203 2091449 In conclusion , our data indicate that signaling is *required* to induce maximal [TNF-alpha] production in macrophages during Orientia infection . Positive_regulation TNF MAPK11 19751557 2135273 p38MAPK 's phosphorylation is important in pathogenesis of MODS , and phosphorylation of can *enhance* TNF-alpha mRNA transcription and secretion of [TNF-alpha] from peripheral blood mononuclear cells , which is the mechanism of increased TNF-alpha in MODS . Positive_regulation TNF MAPK11 20010392 2175028 Because p38 ( p38 ) *upregulates* [TNF-alpha] expression and may play a crucial role in pain sensation , we investigated the effect of one injection of inhibitor on expression of the pain related neuropeptide calcitonin gene related peptide (CGRP) . Positive_regulation TNF MAPK11 20068037 2235128 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Positive_regulation TNF MAPK11 20083499 2380891 For the first time , we show that , in fish macrophages , [TNF-a] is processed by TACE-like activity and this cleavage is *dependent* upon the activation of ERK , and JNK signaling pathways by LPS . Positive_regulation TNF MAPK11 20499049 2276357 Expression of [TNF-alpha] and IL-6 in HMC-1 cells treated with bisphenol A is *attenuated* by plant originating glycoprotein ( 75 kDa ) by blocking p38 . Positive_regulation TNF MAPK11 20589681 2334361 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Positive_regulation TNF MAPK11 20646342 2292561 [TNF-alpha] *induced* a significant increase in p38 phosphorylation . Positive_regulation TNF MAPK11 20868379 2337166 [TNF-a] expression was *mediated* in a time dependent manner by p38 , activation of which is under the control of MKP1 . Positive_regulation TNF MAPK11 21208554 2374415 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Positive_regulation TNF MAPK11 21402598 2426925 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Positive_regulation TNF MAPK11 21545687 2554362 [Tumour necrosis factor-a (TNF-a)] significantly *induced* phosphorylation of p38 , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation TNF MAPK11 21642540 2446232 Pretreatment with TAT-SNAP-23 inhibited the increase in plasma membrane expression of gp91(phox) in TNF-a primed neutrophils , whereas [TNF-a] *activation* of ERK1/2 and p38 was not affected . Positive_regulation TNF MAPK11 21849907 2495989 All 3 inhibitors *suppressed* LPS induced [TNF-a] and I-309 expression in human primary monocytes . Positive_regulation TNF MAPK11 22002864 2526299 In this study , we found that inhibition of p38 with SB-203580 ( SB ) *reduced* H ( 2 ) O ( 2 ) -stimulated secretion of TNF-a , whereas pre-activation of p38 MAPK with sodium arsenite ( SA ) enhanced H ( 2 ) O ( 2 ) -stimulated secretion of [TNF-a] . Positive_regulation TNF MAPK11 22343222 2617758 Using immunohistological techniques , we showed a higher epithelial expression of [TNF-a] , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation TNF MAPK11 22385244 2566470 The use of selective inhibitors of signalling pathways revealed that induction of TG2 by IFN-? was mediated by phosphoinositide 3-kinase (PI3K) , while c-Jun N-terminal kinase (JNK) and p38 were *required* for [TNF-a] activation . Positive_regulation TNF MAPK11 22744777 2853444 After LPS administration , all animals displayed increased arterial carbon dioxide partial pressure ( PaCO2 ) and decreased arterial oxygen partial pressure ( PaO2 ) , arterial oxygen saturation ( SO2 ) , HCO3 ( - ) concentration and pH , and *increased* LWCI , MPO activity , interleukin (IL)-1ß , IL-6 and [tumor necrosis factor (TNF)-a] mRNA expression , NF-?B p65 positive staining and p38 activation compared with normal controls ( all P < 0.01 ) . Positive_regulation TNF MAPK11 23188524 2745407 We found that and Akt inhibitors , but not PI3K inhibitor , remarkably *suppressed* ACPA mediated [TNF-a] production . Positive_regulation TNF MAPK11 23354775 2769954 p38a may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , [tumor necrosis factor-a] , interleukin-1ß , and oxidative stress . Positive_regulation TNF MAPK11 23364439 2754521 Conversely , HTS activated p38 mitogen activated protein kinase (MAPK) and enhanced [TNF-a] *activation* of p38 . Positive_regulation TNF MAPK11 23557259 2777802 Inhibition of and CD137 signaling *reduce* dengue virus induced [TNF-a] secretion and apoptosis . Positive_regulation TNF MAPK11 23734186 2796925 Bla g 2 can stimulate up-regulation of inflammatory cytokines including [TNF-alpha] and IL-6 and *activation* of nuclear factor kappa B ( NF-kB/p65 ) , p38 ( p38 ) , ERK , and JNK in cultured fibrocytes . Positive_regulation TNF MAPK11 24089494 2848132 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed [TNF] receptor 1 and *requires* activation of p38 , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation TNF MAPK11 24441870 2922967 On the other hand , [TNF-a] could *induce* Akt and p42/p44 translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation TNF MAPK11 24750790 2936514 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas [TNFalpha] and NO production *required* all three . Positive_regulation TNF MAPK11 7722327 301742 [TNF-alpha] *induces* tyrosine phosphorylation of in adherent human neutrophils . Positive_regulation TNF MAPK11 7722327 301794 These results indicate that [TNF] signaling *involves* activation of . Positive_regulation TNF MAPK11 9148963 430049 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Positive_regulation TNF MAPK11 9418855 480526 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Positive_regulation TNF MAPK11 9439626 482880 These findings suggest a role for [TNF-alpha] in the regulation of intestinal epithelial cell growth and that the mitogenic effect of TNF-alpha *requires* protein tyrosine phosphorylation and activation . Positive_regulation TNF MAPK11 9551930 499078 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , IL-1beta , and [TNF-alpha] , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation TNF MAPK11 9706151 526172 We hypothesized that hydrogen peroxide ( H2O2 ) induces myocardial dysfunction and cardiomyocyte death via P38 *mediated* myocardial [tumor necrosis factor (TNF)] production . Positive_regulation TNF MAPK11 9730957 530344 However , in contrast to the wild-type endotoxin , it failed to induce significant production of [tumor necrosis factor-alpha] and macrophage inflammatory protein-1alpha by monocytes and did not *induce* the phosphorylation and nuclear translocation of . Positive_regulation TNF MAPK11 9766635 538488 [TNF-alpha] and GM-CSF priming of superoxide release stimulated by N-formyl-methionyl-leucyl-phenylalanine was significantly *attenuated* by the MEK inhibitor , PD098059 , and the p38 inhibitor , SB203580 . Positive_regulation TNF MAPK11 9864164 582560 A selective p38 inhibitor , SB203580 , *blocked* [TNF] -- or ceramide induced CREB phosphorylation , but had no effect on the induction of apoptosis mediated by these agents . Positive_regulation TNF MAPK11 9864164 582641 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Positive_regulation TNF MAPK11 9883899 558193 *Activation* of p42/p44 mitogen activated protein kinases (MAPK) and p38 by [tumor necrosis factor (TNF)] is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation TNF MAPK12 10079106 595508 Specific inhibitors of p38alpha *blocked* LPS induced adhesion , nuclear factor-kappa B (NF-kappaB) activation , and synthesis of [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF MAPK12 10079106 595562 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Positive_regulation TNF MAPK12 10079106 595575 These findings support a pathway by which LPS stimulation of neutrophils results in activation of MKK3 , which in turn activates p38alpha , ultimately regulating adhesion , NF-kappaB activation , *enhanced* gene expression of [TNF-alpha] , and regulation of TNF-alpha synthesis . Positive_regulation TNF MAPK12 10210635 607638 ( 1 ) The human heart produces TNF-alpha after I/R , ( 2 ) p38 *mediates* myocardial I/R induced [TNF-alpha] production , ( 3 ) p38 MAPK inhibition limits functional impairment after I/R , and ( 4 ) inhibition of ischemia induced TNF-alpha production may represent a potent therapeutic strategy for improving myocardial function after angioplasty , coronary bypass , or heart transplantation . Positive_regulation TNF MAPK12 10329111 613026 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Positive_regulation TNF MAPK12 10521481 653037 Engagement of tumor necrosis factor (TNF) receptor 1 leads to ATF-2- and p38 *dependent* [TNF-alpha] gene expression . Positive_regulation TNF MAPK12 10521481 653095 The study presented here shows that autoregulation of [TNF-alpha] gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation TNF MAPK12 10586056 571701 Ligation of microglial CD40 results in p44/42 *dependent* [TNF-alpha] production that is opposed by TGF-beta 1 and IL-10 . Positive_regulation TNF MAPK12 10586056 571755 Inhibition of the upstream activator of p44/42 , mitogen activated protein/extracellular signal related kinase kinase 1/2 , with PD98059 , decreases phosphorylation of p44/42 MAPK and significantly *reduces* [TNF-alpha] release following ligation of microglial CD40 . Positive_regulation TNF MAPK12 10601128 574174 [Tumor necrosis factor-alpha (TNF-alpha)] alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation TNF MAPK12 10620700 657668 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Positive_regulation TNF MAPK12 10653605 663293 These results suggest that ( 1 ) while PTK and are *essential* for the production of [TNFalpha] , they are not necessary for the induction of MnSOD by LPS , and ( 2 ) while activation of NFkappaB alone is insufficient for the induction of TNFalpha mRNA by LPS , it is necessary for the induction of TNFalpha as well as MnSOD mRNAs . Positive_regulation TNF MAPK12 10655266 663525 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Positive_regulation TNF MAPK12 10657669 664188 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Positive_regulation TNF MAPK12 10669634 665793 In this study , we show that [TNF-alpha] *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation TNF MAPK12 10783388 707821 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Positive_regulation TNF MAPK12 10857765 704532 These findings indicate that beta2-adrenoceptor stimulation during an LPS challenge prevented [TNF-alpha] production as a *consequence* of inhibition and enhanced cAMP generation , which at a later stage was associated with an anti-inflammatory effect of IL-6 . Positive_regulation TNF MAPK12 11076936 786251 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Positive_regulation TNF MAPK12 11153597 761138 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as [tumour necrosis factor-alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) , in vitro and in vivo by inhibiting p38 . Positive_regulation TNF MAPK12 11221891 787430 Kinase suppressor of ras is necessary for [tumor necrosis factor] alpha *activation* of extracellular signal regulated in intestinal epithelial cells . Positive_regulation TNF MAPK12 11221891 787456 activity is *essential* for [tumor necrosis factor (TNF)] alpha receptor 1 regulation of intestinal epithelial cell proliferation . Positive_regulation TNF MAPK12 11278471 802558 [Tumor necrosis factor-alpha] induction of endothelial ephrin A1 expression is *mediated* by a p38 and SAPK/JNK dependent but nuclear factor-kappa B-independent mechanism . Positive_regulation TNF MAPK12 11299196 803164 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Positive_regulation TNF MAPK12 11443053 833725 Finally , PD-98059 , a p42/44 pathway inhibitor , *blocked* [TNF-alpha] upregulation by eNOS ( P = 0.02 ) . Positive_regulation TNF MAPK12 11443055 833739 p38 *mediates* renal tubular cell [TNF-alpha] production and TNF-alpha dependent apoptosis during simulated ischemia . Positive_regulation TNF MAPK12 11443055 833779 Furthermore , 60 min of ischemia induced renal tubular cell apoptosis at all substrate replacement time points examined , with peak apoptotic cell death occurring after either 24 or 48 h . p38 MAPK inhibition abolished [TNF-alpha] mRNA production and TNF-alpha bioactivity , and both p38 inhibition and TNF-alpha neutralization ( anti-porcine TNF-alpha antibody ) *prevented* apoptosis after 60 min of SI . Positive_regulation TNF MAPK12 11443055 833792 These results constitute the initial demonstration that 1 ) renal tubular cells produce TNF-alpha mRNA and biologically active [TNF-alpha] and undergo apoptosis in response to SI , and 2 ) p38 *mediates* renal tubular cell TNF-alpha production and TNF-alpha dependent apoptosis after SI . Positive_regulation TNF MAPK12 11675371 873175 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Positive_regulation TNF MAPK12 11699878 878389 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Positive_regulation TNF MAPK12 11715476 581270 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Positive_regulation TNF MAPK12 11728947 884756 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Positive_regulation TNF MAPK12 11815388 907593 ( ERK ) blockade ( PD-98059 ) *attenuated* [TNF-alpha] secretion , an effect synergistically amplified in the presence of SB-203580 . Positive_regulation TNF MAPK12 11994432 938936 Evidence for a dual mechanism for IL-10 suppression of [TNF-alpha] production that does not *involve* inhibition of p38 or NF-kappa B in primary human macrophages . Positive_regulation TNF MAPK12 12130576 966548 Phosphorylation of p38 was *induced* by RANKL , IL-1 , [TNFalpha] , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation TNF MAPK12 12391245 1007382 Release of [TNF-alpha] , macrophage-inflammatory protein (MIP)-2 ( MIP-1beta ) , and IL-8 by LPS stimulated neutrophils was also *reduced* by poststimulation p38 inhibition . Positive_regulation TNF MAPK12 12392277 1007661 Inhibition of p38 with SB203580 *inhibited* the production of [TNF-alpha] and IL-10 by LPS stimulated KCs , whereas blockade of ERK1/2 with PD98059 could reduce TNF-alpha production , but did not affect IL-10 production . Positive_regulation TNF MAPK12 12393915 1025400 This model probiotic also inhibits *activation* of the pro-apoptotic by [tumor necrosis factor] , interleukin-1alpha , or gamma-interferon . Positive_regulation TNF MAPK12 12438325 1016563 The activation of protein tyrosine kinases (PTK) and the serine/threonine kinases p38 and ERK was apparently *required* for MTSA-10 induction of [TNF-alpha] and NO release , as revealed by specific kinase inhibitors . Positive_regulation TNF MAPK12 12506117 1056927 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Positive_regulation TNF MAPK12 12631113 1067650 The present data indicate that [TNF-alpha] *activation* of PKCzeta/iota , p42/44 , c-Jun/AP-1 , and p65/NF-kappaB are involved in TNF-alpha stimulated MC fractalkine expression , with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro . Positive_regulation TNF MAPK12 12637577 1099253 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and [tumor necrosis factor alpha (TNFalpha)] *requires* p38 activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation TNF MAPK12 12694807 1080896 [TNF-alpha] *induced* the phosphorylation of p44/p42 and p38 MAP kinase . Positive_regulation TNF MAPK12 12881424 1116117 Importantly , [TNF] does not *induce* ROS accumulation or prolonged activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death Positive_regulation TNF MAPK12 12969251 1139150 Inhibition of the MAP-kinase-kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) pathway , but not that of ( MAPK-p38 ) , *reduced* NO , [TNF-alpha] and IL-6 significantly , suggesting that simultaneous activation of the first two pathways is necessary for the AGE induced induction of these pro-inflammatory stimuli . Positive_regulation TNF MAPK12 14654378 1176813 These findings suggest that the pre-ischemic *activation* of by [TNF] does not contribute to cardioprotection afforded by this agent . Positive_regulation TNF MAPK12 14980980 1220292 The selective p38 inhibitor , SB203580 , *inhibited* the promoter activities of iNOS and COX-2 rather than that of [TNF-alpha] . Positive_regulation TNF MAPK12 15027449 1222850 Apoptosis caused by chronic ethanol treatment may be due to ethanol potentiation of [TNF] *induced* activation of p38 . Positive_regulation TNF MAPK12 15100302 1239718 Previous studies have shown the mitogen activated protein kinases ( MAPKs ) to be activated in macrophages upon infection with Mycobacterium , and that expression of [TNF-alpha] and inducible NO synthase by infected macrophages was *dependent* on activation . Positive_regulation TNF MAPK12 15139014 1246943 The increase in [TNF-alpha] release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation TNF MAPK12 15233873 1269376 A. semen also inhibited the expression of [TNF-alpha] and the *activation* of , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation TNF MAPK12 15248214 1271207 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of [TNFalpha] and IL-1beta by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation TNF MAPK12 15302094 1283836 Selective p42/44 inhibitor could *reduce* the Pb- and LPS triggered [TNF-alpha] expression in U-373MG cells . Positive_regulation TNF MAPK12 15557189 1340409 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Positive_regulation TNF MAPK12 15557189 1340435 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Positive_regulation TNF MAPK12 15592496 1375214 Tenascin-W is found in malignant mammary tumors , promotes alpha8 integrin dependent motility and *requires* activity for BMP-2 and [TNF-alpha] induced expression in vitro . Positive_regulation TNF MAPK12 15614136 1357461 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Positive_regulation TNF MAPK12 15701814 1416526 p38 activation *leads* to increased production of [TNF-alpha] in ischemic injury and in macrophages . Positive_regulation TNF MAPK12 15701814 1416553 Inhibition of p38 activation *led* to inhibition of [TNF-alpha] production . Positive_regulation TNF MAPK12 15703956 1497453 *Activation* of p38 and phosphatidylinositol 3-kinase (PI3K) by [TNF-alpha] was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation TNF MAPK12 15833800 1425437 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Positive_regulation TNF MAPK12 15867183 1404200 In cultured cardiac myocytes , specific activation of stress activated , p38 , by upstream activator MKK6bE *led* to significant induction of [tumor necrosis factor-alpha] and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation TNF MAPK12 15893422 1419730 We also investigated whether specific inhibition of p38 and Erk1/2 would *inhibit* [TNF-alpha] and IL-6 production and thus astrocyte apoptosis , and proliferation , respectively . Positive_regulation TNF MAPK12 15925386 1440371 Our observations show that calcium , activation , HIF-1alpha , and NF-kappaB are *necessary* for ethanol induced [TNF-alpha] and TGF-beta1 expression . Positive_regulation TNF MAPK12 16051807 1438609 Specific inhibitors of p38 significantly *reduced* the H5N1/97 induced [TNF-alpha] expression in macrophages . Positive_regulation TNF MAPK12 16081599 1460335 These results indicate that gp120 elicited [TNF-alpha] production by macrophages *involves* chemokine receptor mediated PI-3K and activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and ERK-1/2 independently regulate TNF-alpha production . Positive_regulation TNF MAPK12 16271232 1479203 Similarly , the increased gene expression of proinflammatory cytokines [TNF-alpha] and IL-1beta in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation TNF MAPK12 16275991 1480268 Angiotensin II , [tumor necrosis factor-alpha] , or epidermal growth factor *induced* phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation TNF MAPK12 16291729 1526053 *Activation* of and Akt by anti-HER2/neu [ScFv-TNF-alpha] inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation TNF MAPK12 16403817 1540126 The [TNF] + dex stimulated increase in leptin was associated with an increase in p38 MAPK activity and was totally *blocked* by p38 inhibitors . Positive_regulation TNF MAPK12 16438946 1495427 Although gAd partially increased cAMP concentration and PKA activity , it directly reduced leptin induced ERK1/2 and p38 phosphorylation thus *inhibiting* [TNF-alpha] production . Positive_regulation TNF MAPK12 16480618 1496065 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Positive_regulation TNF MAPK12 16480618 1496104 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Positive_regulation TNF MAPK12 16517732 1530903 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of [TNF] , but not IL-6 , *requires* the activity of p38 . Positive_regulation TNF MAPK12 16573652 1556122 HA-mediated [TNF-alpha] production *required* p38 , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation TNF MAPK12 16581537 1543736 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Positive_regulation TNF MAPK12 16596287 1544882 These results collectively reveal that AV-ext *inhibits* [TNF-alpha] release from macrophages by suppressing and NF-kappaB signaling pathways and suggest that AV-ext may be beneficial for the treatment of endotoxin shock or sepsis . Positive_regulation TNF MAPK12 16771851 1572705 this process then leads to modulation of p38 *dependent* IL-8 and [TNF-alpha] release from the epithelium . Positive_regulation TNF MAPK12 16781693 1585601 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and [TNF-alpha] and the *activation* of 's are potentially positive signals for IL-10 production . Positive_regulation TNF MAPK12 16867160 1592834 Further , the activation of p38 and extracellular signal regulated kinase was *required* for the induction of [TNF-alpha] and IL-6 by MTB12 , as well as by the 30-kDa Ag . Positive_regulation TNF MAPK12 17032936 1692722 The stimulation of [TNF-alpha] production was *dependent* on cisplatin induced activation of p38 and was associated with phosphorylation of the translation initiation factor eIF4E and its upstream kinase Mnk1 . Positive_regulation TNF MAPK12 17032936 1692735 Inhibition of p38 and , to a lesser extent , ERK , *reduced* cisplatin+endotoxin stimulated [TNF-alpha] production and phosphorylation of Mnk1 and eIF4E . Positive_regulation TNF MAPK12 17074860 1675543 B. burgdorferi induced [TNF-alpha] production is also *dependent* on the activation of p38 . Positive_regulation TNF MAPK12 17117477 1677355 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Positive_regulation TNF MAPK12 17126905 1686515 Differential regulation of [TNFalpha] and GM-CSF *induced* activation of P38 in neutrophils and eosinophils . Positive_regulation TNF MAPK12 17131360 1700729 In addition , we recently found that p38 *mediates* [TNF-alpha] upregulation of atrogin-1/MAFbx expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation TNF MAPK12 17138860 1653558 The purpose of this study was to determine whether the , ERK1/2 , and p38 MAPK are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Positive_regulation TNF MAPK12 17172975 1679372 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK12 17172975 1679398 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK12 17202326 1680800 Augmented lipopolysaccharide induced [TNF-alpha] production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK12 17202326 1680826 In this study , we show that augmented LPS induced [TNF-alpha] production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK12 17395780 1766147 Here we demonstrate that Rab7b can negatively regulate lipopolysaccharide (LPS) induced production of [tumor necrosis factor (TNF)-alpha] , IL-6 , nitric oxide , and IFN-beta , and potentiate LPS induced *activation* of , nuclear factor kappaB , and IFN regulatory factor 3 signaling pathways in macrophages by promoting the degradation of TLR4 . Positive_regulation TNF MAPK12 17438131 1742741 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by [TNF-alpha] and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation TNF MAPK12 17553937 1791993 Twenty-four hours thereafter , splenic macrophages were isolated , and their IL-6 and [TNF-alpha] production and *activation* of and NF-kappaB were measured . Positive_regulation TNF MAPK12 17607712 1798173 Although [TNF] *induced* the activation of p38 , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation TNF MAPK12 17902045 1835074 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Positive_regulation TNF MAPK12 17934341 1813481 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Positive_regulation TNF MAPK12 17940160 1888981 Conversely , Ser phosphorylation of IRS-2 mediated by [TNF-alpha] *activation* of was the mechanism found in brown adipocytes . Positive_regulation TNF MAPK12 17964662 1831047 Taken together , these results suggest that linomide *inhibits* [TNF-alpha] production by suppressing the activation of NF-kappaB and , which might , at least in part , contribute to the beneficial effects of linomide in the treatment of autoimmune diseases . Positive_regulation TNF MAPK12 17994109 1851142 [TNF-alpha] triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation TNF MAPK12 18227157 1884331 It was shown that these three proteins could ( i ) induce expression of [tumor necrosis factor alpha (TNF-alpha)] and tissue factor and ( ii ) *induce* phosphorylation of p44/42 and activation of early growth response factor 1 (Egr-1) . Positive_regulation TNF MAPK12 18296636 1878858 Whereas the induction of [TNFalpha] , IL-1beta , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation TNF MAPK12 18303184 1873521 Inhibition of p38 activation selectively *blocked* DNCB induced [TNF-alpha] release , but not NiSO ( 4 ) -induced release . Positive_regulation TNF MAPK12 18314537 1919431 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Positive_regulation TNF MAPK12 18390808 1925664 We tested the hypothesis that p38 activation is *necessary* for [TNF-alpha] production , neutrophil activation , and subsequent liver injury . Positive_regulation TNF MAPK12 18622138 1984356 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Positive_regulation TNF MAPK12 18675993 2011327 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Positive_regulation TNF MAPK12 19002259 1991229 Peptidoglycan stimulated monocyte p38 and p38 activity was *required* for [TNFalpha] production by the cells . Positive_regulation TNF MAPK12 19040616 2017405 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Positive_regulation TNF MAPK12 19043204 1998818 Moreover , [TNF-alpha] production was *prevented* by NF-kappaB and inhibitors . Positive_regulation TNF MAPK12 19052649 1999784 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Positive_regulation TNF MAPK12 19250666 2055375 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Positive_regulation TNF MAPK12 19267548 2045600 Since activated p38 *mediates* [TNF-alpha] production , we examined the effect of radiation on LPS induced activation of p38 MAPK and TNF-alpha production . Positive_regulation TNF MAPK12 19287189 2046602 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Positive_regulation TNF MAPK12 19351958 2088777 Specific inhibitors of p38 and glycogen synthase kinase 3 *suppressed* [TNF-alpha] production and maturation of fucoidan treated PBDCs . Positive_regulation TNF MAPK12 19427347 2106780 [TNF-alpha] *induced* the phosphorylation of p38 , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation TNF MAPK12 19477265 2107658 These results show that chronic ethanol feeding enhances Fas induced liver injury by a mechanism associated with induction of CYP2E1 , elevated serum [TNF-alpha] levels , and *activation* of . Positive_regulation TNF MAPK12 19493203 2091424 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Positive_regulation TNF MAPK12 19493203 2091450 In conclusion , our data indicate that signaling is *required* to induce maximal [TNF-alpha] production in macrophages during Orientia infection . Positive_regulation TNF MAPK12 19751557 2135274 p38MAPK 's phosphorylation is important in pathogenesis of MODS , and phosphorylation of can *enhance* TNF-alpha mRNA transcription and secretion of [TNF-alpha] from peripheral blood mononuclear cells , which is the mechanism of increased TNF-alpha in MODS . Positive_regulation TNF MAPK12 20010392 2175029 Because p38 ( p38 ) *upregulates* [TNF-alpha] expression and may play a crucial role in pain sensation , we investigated the effect of one injection of inhibitor on expression of the pain related neuropeptide calcitonin gene related peptide (CGRP) . Positive_regulation TNF MAPK12 20068037 2235129 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Positive_regulation TNF MAPK12 20083499 2380892 For the first time , we show that , in fish macrophages , [TNF-a] is processed by TACE-like activity and this cleavage is *dependent* upon the activation of ERK , and JNK signaling pathways by LPS . Positive_regulation TNF MAPK12 20499049 2276358 Expression of [TNF-alpha] and IL-6 in HMC-1 cells treated with bisphenol A is *attenuated* by plant originating glycoprotein ( 75 kDa ) by blocking p38 . Positive_regulation TNF MAPK12 20589681 2334362 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Positive_regulation TNF MAPK12 20646342 2292562 [TNF-alpha] *induced* a significant increase in p38 phosphorylation . Positive_regulation TNF MAPK12 20868379 2337167 [TNF-a] expression was *mediated* in a time dependent manner by p38 , activation of which is under the control of MKP1 . Positive_regulation TNF MAPK12 21208554 2374416 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Positive_regulation TNF MAPK12 21402598 2426926 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Positive_regulation TNF MAPK12 21545687 2554363 [Tumour necrosis factor-a (TNF-a)] significantly *induced* phosphorylation of p38 , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation TNF MAPK12 21642540 2446233 Pretreatment with TAT-SNAP-23 inhibited the increase in plasma membrane expression of gp91(phox) in TNF-a primed neutrophils , whereas [TNF-a] *activation* of ERK1/2 and p38 was not affected . Positive_regulation TNF MAPK12 21849907 2495990 All 3 inhibitors *suppressed* LPS induced [TNF-a] and I-309 expression in human primary monocytes . Positive_regulation TNF MAPK12 22002864 2526300 In this study , we found that inhibition of p38 with SB-203580 ( SB ) *reduced* H ( 2 ) O ( 2 ) -stimulated secretion of [TNF-a] , whereas pre-activation of p38 MAPK with sodium arsenite ( SA ) enhanced H ( 2 ) O ( 2 ) -stimulated secretion of TNF-a . Positive_regulation TNF MAPK12 22343222 2617759 Using immunohistological techniques , we showed a higher epithelial expression of [TNF-a] , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation TNF MAPK12 22385244 2566471 The use of selective inhibitors of signalling pathways revealed that induction of TG2 by IFN-? was mediated by phosphoinositide 3-kinase (PI3K) , while c-Jun N-terminal kinase (JNK) and p38 were *required* for [TNF-a] activation . Positive_regulation TNF MAPK12 22744777 2853445 After LPS administration , all animals displayed increased arterial carbon dioxide partial pressure ( PaCO2 ) and decreased arterial oxygen partial pressure ( PaO2 ) , arterial oxygen saturation ( SO2 ) , HCO3 ( - ) concentration and pH , and *increased* LWCI , MPO activity , interleukin (IL)-1ß , IL-6 and [tumor necrosis factor (TNF)-a] mRNA expression , NF-?B p65 positive staining and p38 activation compared with normal controls ( all P < 0.01 ) . Positive_regulation TNF MAPK12 23188524 2745408 We found that and Akt inhibitors , but not PI3K inhibitor , remarkably *suppressed* ACPA mediated [TNF-a] production . Positive_regulation TNF MAPK12 23354775 2769955 p38a may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , [tumor necrosis factor-a] , interleukin-1ß , and oxidative stress . Positive_regulation TNF MAPK12 23364439 2754522 Conversely , HTS activated p38 mitogen activated protein kinase (MAPK) and enhanced [TNF-a] *activation* of p38 . Positive_regulation TNF MAPK12 23557259 2777803 Inhibition of and CD137 signaling *reduce* dengue virus induced [TNF-a] secretion and apoptosis . Positive_regulation TNF MAPK12 23734186 2796926 Bla g 2 can stimulate up-regulation of inflammatory cytokines including [TNF-alpha] and IL-6 and *activation* of nuclear factor kappa B ( NF-kB/p65 ) , p38 ( p38 ) , ERK , and JNK in cultured fibrocytes . Positive_regulation TNF MAPK12 24089494 2848133 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed [TNF] receptor 1 and *requires* activation of p38 , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation TNF MAPK12 24441870 2922968 On the other hand , [TNF-a] could *induce* Akt and p42/p44 translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation TNF MAPK12 24750790 2936515 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas [TNFalpha] and NO production *required* all three . Positive_regulation TNF MAPK12 7722327 301743 [TNF-alpha] *induces* tyrosine phosphorylation of in adherent human neutrophils . Positive_regulation TNF MAPK12 7722327 301795 These results indicate that [TNF] signaling *involves* activation of . Positive_regulation TNF MAPK12 9148963 430050 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Positive_regulation TNF MAPK12 9418855 480527 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Positive_regulation TNF MAPK12 9439626 482881 These findings suggest a role for [TNF-alpha] in the regulation of intestinal epithelial cell growth and that the mitogenic effect of TNF-alpha *requires* protein tyrosine phosphorylation and activation . Positive_regulation TNF MAPK12 9551930 499079 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , IL-1beta , and [TNF-alpha] , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation TNF MAPK12 9706151 526173 We hypothesized that hydrogen peroxide ( H2O2 ) induces myocardial dysfunction and cardiomyocyte death via P38 *mediated* myocardial [tumor necrosis factor (TNF)] production . Positive_regulation TNF MAPK12 9730957 530345 However , in contrast to the wild-type endotoxin , it failed to induce significant production of [tumor necrosis factor-alpha] and macrophage inflammatory protein-1alpha by monocytes and did not *induce* the phosphorylation and nuclear translocation of . Positive_regulation TNF MAPK12 9766635 538489 [TNF-alpha] and GM-CSF priming of superoxide release stimulated by N-formyl-methionyl-leucyl-phenylalanine was significantly *attenuated* by the MEK inhibitor , PD098059 , and the p38 inhibitor , SB203580 . Positive_regulation TNF MAPK12 9864164 582561 A selective p38 inhibitor , SB203580 , *blocked* [TNF] -- or ceramide induced CREB phosphorylation , but had no effect on the induction of apoptosis mediated by these agents . Positive_regulation TNF MAPK12 9864164 582642 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Positive_regulation TNF MAPK12 9883899 558194 *Activation* of p42/p44 and p38 MAPK by [tumor necrosis factor (TNF)] is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation TNF MAPK13 10079106 595509 Specific inhibitors of p38alpha *blocked* LPS induced adhesion , nuclear factor-kappa B (NF-kappaB) activation , and synthesis of [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF MAPK13 10079106 595563 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Positive_regulation TNF MAPK13 10079106 595576 These findings support a pathway by which LPS stimulation of neutrophils results in activation of MKK3 , which in turn activates p38alpha , ultimately regulating adhesion , NF-kappaB activation , *enhanced* gene expression of [TNF-alpha] , and regulation of TNF-alpha synthesis . Positive_regulation TNF MAPK13 10210635 607639 ( 1 ) The human heart produces TNF-alpha after I/R , ( 2 ) p38 *mediates* myocardial I/R induced [TNF-alpha] production , ( 3 ) p38 MAPK inhibition limits functional impairment after I/R , and ( 4 ) inhibition of ischemia induced TNF-alpha production may represent a potent therapeutic strategy for improving myocardial function after angioplasty , coronary bypass , or heart transplantation . Positive_regulation TNF MAPK13 10329111 613027 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Positive_regulation TNF MAPK13 10521481 653038 Engagement of tumor necrosis factor (TNF) receptor 1 leads to ATF-2- and p38 *dependent* [TNF-alpha] gene expression . Positive_regulation TNF MAPK13 10521481 653096 The study presented here shows that autoregulation of [TNF-alpha] gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation TNF MAPK13 10586056 571702 Ligation of microglial CD40 results in p44/42 *dependent* [TNF-alpha] production that is opposed by TGF-beta 1 and IL-10 . Positive_regulation TNF MAPK13 10586056 571756 Inhibition of the upstream activator of p44/42 , mitogen activated protein/extracellular signal related kinase kinase 1/2 , with PD98059 , decreases phosphorylation of p44/42 MAPK and significantly *reduces* [TNF-alpha] release following ligation of microglial CD40 . Positive_regulation TNF MAPK13 10601128 574175 [Tumor necrosis factor-alpha (TNF-alpha)] alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation TNF MAPK13 10620700 657669 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Positive_regulation TNF MAPK13 10653605 663294 These results suggest that ( 1 ) while PTK and are *essential* for the production of [TNFalpha] , they are not necessary for the induction of MnSOD by LPS , and ( 2 ) while activation of NFkappaB alone is insufficient for the induction of TNFalpha mRNA by LPS , it is necessary for the induction of TNFalpha as well as MnSOD mRNAs . Positive_regulation TNF MAPK13 10655266 663526 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Positive_regulation TNF MAPK13 10657669 664189 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Positive_regulation TNF MAPK13 10669634 665794 In this study , we show that [TNF-alpha] *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation TNF MAPK13 10783388 707822 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Positive_regulation TNF MAPK13 10857765 704533 These findings indicate that beta2-adrenoceptor stimulation during an LPS challenge prevented [TNF-alpha] production as a *consequence* of inhibition and enhanced cAMP generation , which at a later stage was associated with an anti-inflammatory effect of IL-6 . Positive_regulation TNF MAPK13 11076936 786252 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Positive_regulation TNF MAPK13 11153597 761139 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as [tumour necrosis factor-alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) , in vitro and in vivo by inhibiting p38 . Positive_regulation TNF MAPK13 11221891 787431 Kinase suppressor of ras is necessary for [tumor necrosis factor] alpha *activation* of extracellular signal regulated in intestinal epithelial cells . Positive_regulation TNF MAPK13 11221891 787457 activity is *essential* for [tumor necrosis factor (TNF)] alpha receptor 1 regulation of intestinal epithelial cell proliferation . Positive_regulation TNF MAPK13 11278471 802559 [Tumor necrosis factor-alpha] induction of endothelial ephrin A1 expression is *mediated* by a p38 and SAPK/JNK dependent but nuclear factor-kappa B-independent mechanism . Positive_regulation TNF MAPK13 11299196 803165 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Positive_regulation TNF MAPK13 11443053 833726 Finally , PD-98059 , a p42/44 pathway inhibitor , *blocked* [TNF-alpha] upregulation by eNOS ( P = 0.02 ) . Positive_regulation TNF MAPK13 11443055 833740 p38 *mediates* renal tubular cell [TNF-alpha] production and TNF-alpha dependent apoptosis during simulated ischemia . Positive_regulation TNF MAPK13 11443055 833780 Furthermore , 60 min of ischemia induced renal tubular cell apoptosis at all substrate replacement time points examined , with peak apoptotic cell death occurring after either 24 or 48 h . p38 MAPK inhibition abolished [TNF-alpha] mRNA production and TNF-alpha bioactivity , and both p38 inhibition and TNF-alpha neutralization ( anti-porcine TNF-alpha antibody ) *prevented* apoptosis after 60 min of SI . Positive_regulation TNF MAPK13 11443055 833793 These results constitute the initial demonstration that 1 ) renal tubular cells produce TNF-alpha mRNA and biologically active [TNF-alpha] and undergo apoptosis in response to SI , and 2 ) p38 *mediates* renal tubular cell TNF-alpha production and TNF-alpha dependent apoptosis after SI . Positive_regulation TNF MAPK13 11675371 873176 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Positive_regulation TNF MAPK13 11699878 878390 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Positive_regulation TNF MAPK13 11715476 581271 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Positive_regulation TNF MAPK13 11728947 884757 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Positive_regulation TNF MAPK13 11815388 907594 ( ERK ) blockade ( PD-98059 ) *attenuated* [TNF-alpha] secretion , an effect synergistically amplified in the presence of SB-203580 . Positive_regulation TNF MAPK13 11994432 938937 Evidence for a dual mechanism for IL-10 suppression of [TNF-alpha] production that does not *involve* inhibition of p38 or NF-kappa B in primary human macrophages . Positive_regulation TNF MAPK13 12130576 966549 Phosphorylation of p38 was *induced* by RANKL , IL-1 , [TNFalpha] , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation TNF MAPK13 12391245 1007383 Release of [TNF-alpha] , macrophage-inflammatory protein (MIP)-2 ( MIP-1beta ) , and IL-8 by LPS stimulated neutrophils was also *reduced* by poststimulation p38 inhibition . Positive_regulation TNF MAPK13 12392277 1007662 Inhibition of p38 with SB203580 *inhibited* the production of [TNF-alpha] and IL-10 by LPS stimulated KCs , whereas blockade of ERK1/2 with PD98059 could reduce TNF-alpha production , but did not affect IL-10 production . Positive_regulation TNF MAPK13 12393915 1025401 This model probiotic also inhibits *activation* of the pro-apoptotic by [tumor necrosis factor] , interleukin-1alpha , or gamma-interferon . Positive_regulation TNF MAPK13 12438325 1016564 The activation of protein tyrosine kinases (PTK) and the serine/threonine kinases p38 and ERK was apparently *required* for MTSA-10 induction of [TNF-alpha] and NO release , as revealed by specific kinase inhibitors . Positive_regulation TNF MAPK13 12506117 1056928 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Positive_regulation TNF MAPK13 12631113 1067651 The present data indicate that [TNF-alpha] *activation* of PKCzeta/iota , p42/44 , c-Jun/AP-1 , and p65/NF-kappaB are involved in TNF-alpha stimulated MC fractalkine expression , with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro . Positive_regulation TNF MAPK13 12637577 1099254 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and [tumor necrosis factor alpha (TNFalpha)] *requires* p38 activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation TNF MAPK13 12694807 1080897 [TNF-alpha] *induced* the phosphorylation of p44/p42 and p38 MAP kinase . Positive_regulation TNF MAPK13 12881424 1116118 Importantly , [TNF] does not *induce* ROS accumulation or prolonged activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death Positive_regulation TNF MAPK13 12969251 1139151 Inhibition of the MAP-kinase-kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) pathway , but not that of ( MAPK-p38 ) , *reduced* NO , [TNF-alpha] and IL-6 significantly , suggesting that simultaneous activation of the first two pathways is necessary for the AGE induced induction of these pro-inflammatory stimuli . Positive_regulation TNF MAPK13 14654378 1176814 These findings suggest that the pre-ischemic *activation* of by [TNF] does not contribute to cardioprotection afforded by this agent . Positive_regulation TNF MAPK13 14980980 1220293 The selective p38 inhibitor , SB203580 , *inhibited* the promoter activities of iNOS and COX-2 rather than that of [TNF-alpha] . Positive_regulation TNF MAPK13 15027449 1222851 Apoptosis caused by chronic ethanol treatment may be due to ethanol potentiation of [TNF] *induced* activation of p38 . Positive_regulation TNF MAPK13 15100302 1239719 Previous studies have shown the mitogen activated protein kinases ( MAPKs ) to be activated in macrophages upon infection with Mycobacterium , and that expression of [TNF-alpha] and inducible NO synthase by infected macrophages was *dependent* on activation . Positive_regulation TNF MAPK13 15139014 1246944 The increase in [TNF-alpha] release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation TNF MAPK13 15233873 1269377 A. semen also inhibited the expression of [TNF-alpha] and the *activation* of , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation TNF MAPK13 15248214 1271208 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of [TNFalpha] and IL-1beta by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation TNF MAPK13 15302094 1283837 Selective p42/44 inhibitor could *reduce* the Pb- and LPS triggered [TNF-alpha] expression in U-373MG cells . Positive_regulation TNF MAPK13 15557189 1340410 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Positive_regulation TNF MAPK13 15557189 1340436 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Positive_regulation TNF MAPK13 15592496 1375215 Tenascin-W is found in malignant mammary tumors , promotes alpha8 integrin dependent motility and *requires* activity for BMP-2 and [TNF-alpha] induced expression in vitro . Positive_regulation TNF MAPK13 15614136 1357462 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Positive_regulation TNF MAPK13 15701814 1416527 p38 activation *leads* to increased production of [TNF-alpha] in ischemic injury and in macrophages . Positive_regulation TNF MAPK13 15701814 1416554 Inhibition of p38 activation *led* to inhibition of [TNF-alpha] production . Positive_regulation TNF MAPK13 15703956 1497454 *Activation* of p38 and phosphatidylinositol 3-kinase (PI3K) by [TNF-alpha] was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation TNF MAPK13 15833800 1425438 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Positive_regulation TNF MAPK13 15867183 1404201 In cultured cardiac myocytes , specific activation of stress activated , p38 , by upstream activator MKK6bE *led* to significant induction of [tumor necrosis factor-alpha] and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation TNF MAPK13 15893422 1419731 We also investigated whether specific inhibition of p38 and Erk1/2 would *inhibit* [TNF-alpha] and IL-6 production and thus astrocyte apoptosis , and proliferation , respectively . Positive_regulation TNF MAPK13 15925386 1440372 Our observations show that calcium , activation , HIF-1alpha , and NF-kappaB are *necessary* for ethanol induced [TNF-alpha] and TGF-beta1 expression . Positive_regulation TNF MAPK13 16051807 1438610 Specific inhibitors of p38 significantly *reduced* the H5N1/97 induced [TNF-alpha] expression in macrophages . Positive_regulation TNF MAPK13 16081599 1460336 These results indicate that gp120 elicited [TNF-alpha] production by macrophages *involves* chemokine receptor mediated PI-3K and activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and ERK-1/2 independently regulate TNF-alpha production . Positive_regulation TNF MAPK13 16271232 1479204 Similarly , the increased gene expression of proinflammatory cytokines [TNF-alpha] and IL-1beta in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation TNF MAPK13 16275991 1480269 Angiotensin II , [tumor necrosis factor-alpha] , or epidermal growth factor *induced* phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation TNF MAPK13 16291729 1526054 *Activation* of and Akt by anti-HER2/neu [ScFv-TNF-alpha] inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation TNF MAPK13 16403817 1540127 The [TNF] + dex stimulated increase in leptin was associated with an increase in p38 MAPK activity and was totally *blocked* by p38 inhibitors . Positive_regulation TNF MAPK13 16438946 1495428 Although gAd partially increased cAMP concentration and PKA activity , it directly reduced leptin induced ERK1/2 and p38 phosphorylation thus *inhibiting* [TNF-alpha] production . Positive_regulation TNF MAPK13 16480618 1496066 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Positive_regulation TNF MAPK13 16480618 1496105 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Positive_regulation TNF MAPK13 16517732 1530904 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of [TNF] , but not IL-6 , *requires* the activity of p38 . Positive_regulation TNF MAPK13 16573652 1556123 HA-mediated [TNF-alpha] production *required* p38 , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation TNF MAPK13 16581537 1543737 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Positive_regulation TNF MAPK13 16596287 1544883 These results collectively reveal that AV-ext *inhibits* [TNF-alpha] release from macrophages by suppressing and NF-kappaB signaling pathways and suggest that AV-ext may be beneficial for the treatment of endotoxin shock or sepsis . Positive_regulation TNF MAPK13 16771851 1572706 this process then leads to modulation of p38 *dependent* IL-8 and [TNF-alpha] release from the epithelium . Positive_regulation TNF MAPK13 16781693 1585602 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and [TNF-alpha] and the *activation* of 's are potentially positive signals for IL-10 production . Positive_regulation TNF MAPK13 16867160 1592835 Further , the activation of p38 and extracellular signal regulated kinase was *required* for the induction of [TNF-alpha] and IL-6 by MTB12 , as well as by the 30-kDa Ag . Positive_regulation TNF MAPK13 17032936 1692723 The stimulation of [TNF-alpha] production was *dependent* on cisplatin induced activation of p38 and was associated with phosphorylation of the translation initiation factor eIF4E and its upstream kinase Mnk1 . Positive_regulation TNF MAPK13 17032936 1692736 Inhibition of p38 and , to a lesser extent , ERK , *reduced* cisplatin+endotoxin stimulated [TNF-alpha] production and phosphorylation of Mnk1 and eIF4E . Positive_regulation TNF MAPK13 17074860 1675544 B. burgdorferi induced [TNF-alpha] production is also *dependent* on the activation of p38 . Positive_regulation TNF MAPK13 17117477 1677356 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Positive_regulation TNF MAPK13 17126905 1686516 Differential regulation of [TNFalpha] and GM-CSF *induced* activation of P38 in neutrophils and eosinophils . Positive_regulation TNF MAPK13 17131360 1700730 In addition , we recently found that p38 *mediates* [TNF-alpha] upregulation of atrogin-1/MAFbx expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation TNF MAPK13 17138860 1653559 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Positive_regulation TNF MAPK13 17172975 1679373 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK13 17172975 1679399 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK13 17202326 1680801 Augmented lipopolysaccharide induced [TNF-alpha] production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK13 17202326 1680827 In this study , we show that augmented LPS induced [TNF-alpha] production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK13 17395780 1766148 Here we demonstrate that Rab7b can negatively regulate lipopolysaccharide (LPS) induced production of [tumor necrosis factor (TNF)-alpha] , IL-6 , nitric oxide , and IFN-beta , and potentiate LPS induced *activation* of , nuclear factor kappaB , and IFN regulatory factor 3 signaling pathways in macrophages by promoting the degradation of TLR4 . Positive_regulation TNF MAPK13 17438131 1742742 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by [TNF-alpha] and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation TNF MAPK13 17553937 1791994 Twenty-four hours thereafter , splenic macrophages were isolated , and their IL-6 and [TNF-alpha] production and *activation* of and NF-kappaB were measured . Positive_regulation TNF MAPK13 17607712 1798174 Although [TNF] *induced* the activation of p38 , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation TNF MAPK13 17902045 1835075 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Positive_regulation TNF MAPK13 17934341 1813482 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Positive_regulation TNF MAPK13 17940160 1888982 Conversely , Ser phosphorylation of IRS-2 mediated by [TNF-alpha] *activation* of was the mechanism found in brown adipocytes . Positive_regulation TNF MAPK13 17964662 1831048 Taken together , these results suggest that linomide *inhibits* [TNF-alpha] production by suppressing the activation of NF-kappaB and , which might , at least in part , contribute to the beneficial effects of linomide in the treatment of autoimmune diseases . Positive_regulation TNF MAPK13 17994109 1851143 [TNF-alpha] triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation TNF MAPK13 18227157 1884332 It was shown that these three proteins could ( i ) induce expression of [tumor necrosis factor alpha (TNF-alpha)] and tissue factor and ( ii ) *induce* phosphorylation of p44/42 and activation of early growth response factor 1 (Egr-1) . Positive_regulation TNF MAPK13 18296636 1878859 Whereas the induction of [TNFalpha] , IL-1beta , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation TNF MAPK13 18303184 1873522 Inhibition of p38 activation selectively *blocked* DNCB induced [TNF-alpha] release , but not NiSO ( 4 ) -induced release . Positive_regulation TNF MAPK13 18314537 1919432 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Positive_regulation TNF MAPK13 18390808 1925665 We tested the hypothesis that p38 activation is *necessary* for [TNF-alpha] production , neutrophil activation , and subsequent liver injury . Positive_regulation TNF MAPK13 18622138 1984357 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Positive_regulation TNF MAPK13 18675993 2011328 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Positive_regulation TNF MAPK13 19002259 1991230 Peptidoglycan stimulated monocyte p38 and p38 activity was *required* for [TNFalpha] production by the cells . Positive_regulation TNF MAPK13 19040616 2017406 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Positive_regulation TNF MAPK13 19043204 1998819 Moreover , [TNF-alpha] production was *prevented* by NF-kappaB and inhibitors . Positive_regulation TNF MAPK13 19052649 1999785 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Positive_regulation TNF MAPK13 19250666 2055376 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Positive_regulation TNF MAPK13 19267548 2045601 Since activated p38 *mediates* [TNF-alpha] production , we examined the effect of radiation on LPS induced activation of p38 MAPK and TNF-alpha production . Positive_regulation TNF MAPK13 19287189 2046603 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Positive_regulation TNF MAPK13 19351958 2088778 Specific inhibitors of p38 and glycogen synthase kinase 3 *suppressed* [TNF-alpha] production and maturation of fucoidan treated PBDCs . Positive_regulation TNF MAPK13 19427347 2106781 [TNF-alpha] *induced* the phosphorylation of p38 , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation TNF MAPK13 19477265 2107659 These results show that chronic ethanol feeding enhances Fas induced liver injury by a mechanism associated with induction of CYP2E1 , elevated serum [TNF-alpha] levels , and *activation* of . Positive_regulation TNF MAPK13 19493203 2091425 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Positive_regulation TNF MAPK13 19493203 2091451 In conclusion , our data indicate that signaling is *required* to induce maximal [TNF-alpha] production in macrophages during Orientia infection . Positive_regulation TNF MAPK13 19751557 2135275 p38MAPK 's phosphorylation is important in pathogenesis of MODS , and phosphorylation of can *enhance* TNF-alpha mRNA transcription and secretion of [TNF-alpha] from peripheral blood mononuclear cells , which is the mechanism of increased TNF-alpha in MODS . Positive_regulation TNF MAPK13 20010392 2175030 Because p38 ( p38 ) *upregulates* [TNF-alpha] expression and may play a crucial role in pain sensation , we investigated the effect of one injection of inhibitor on expression of the pain related neuropeptide calcitonin gene related peptide (CGRP) . Positive_regulation TNF MAPK13 20068037 2235130 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Positive_regulation TNF MAPK13 20083499 2380893 For the first time , we show that , in fish macrophages , [TNF-a] is processed by TACE-like activity and this cleavage is *dependent* upon the activation of ERK , and JNK signaling pathways by LPS . Positive_regulation TNF MAPK13 20499049 2276359 Expression of [TNF-alpha] and IL-6 in HMC-1 cells treated with bisphenol A is *attenuated* by plant originating glycoprotein ( 75 kDa ) by blocking p38 . Positive_regulation TNF MAPK13 20589681 2334363 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Positive_regulation TNF MAPK13 20646342 2292563 [TNF-alpha] *induced* a significant increase in p38 phosphorylation . Positive_regulation TNF MAPK13 20868379 2337168 [TNF-a] expression was *mediated* in a time dependent manner by p38 , activation of which is under the control of MKP1 . Positive_regulation TNF MAPK13 21208554 2374417 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Positive_regulation TNF MAPK13 21402598 2426927 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Positive_regulation TNF MAPK13 21545687 2554364 [Tumour necrosis factor-a (TNF-a)] significantly *induced* phosphorylation of p38 , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation TNF MAPK13 21642540 2446234 Pretreatment with TAT-SNAP-23 inhibited the increase in plasma membrane expression of gp91(phox) in TNF-a primed neutrophils , whereas [TNF-a] *activation* of ERK1/2 and p38 was not affected . Positive_regulation TNF MAPK13 21849907 2495991 All 3 inhibitors *suppressed* LPS induced [TNF-a] and I-309 expression in human primary monocytes . Positive_regulation TNF MAPK13 22002864 2526301 In this study , we found that inhibition of p38 with SB-203580 ( SB ) *reduced* H ( 2 ) O ( 2 ) -stimulated secretion of TNF-a , whereas pre-activation of p38 MAPK with sodium arsenite ( SA ) enhanced H ( 2 ) O ( 2 ) -stimulated secretion of [TNF-a] . Positive_regulation TNF MAPK13 22343222 2617760 Using immunohistological techniques , we showed a higher epithelial expression of [TNF-a] , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation TNF MAPK13 22385244 2566472 The use of selective inhibitors of signalling pathways revealed that induction of TG2 by IFN-? was mediated by phosphoinositide 3-kinase (PI3K) , while c-Jun N-terminal kinase (JNK) and p38 were *required* for [TNF-a] activation . Positive_regulation TNF MAPK13 22744777 2853446 After LPS administration , all animals displayed increased arterial carbon dioxide partial pressure ( PaCO2 ) and decreased arterial oxygen partial pressure ( PaO2 ) , arterial oxygen saturation ( SO2 ) , HCO3 ( - ) concentration and pH , and *increased* LWCI , MPO activity , interleukin (IL)-1ß , IL-6 and [tumor necrosis factor (TNF)-a] mRNA expression , NF-?B p65 positive staining and p38 activation compared with normal controls ( all P < 0.01 ) . Positive_regulation TNF MAPK13 23188524 2745409 We found that and Akt inhibitors , but not PI3K inhibitor , remarkably *suppressed* ACPA mediated [TNF-a] production . Positive_regulation TNF MAPK13 23354775 2769956 p38a may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , [tumor necrosis factor-a] , interleukin-1ß , and oxidative stress . Positive_regulation TNF MAPK13 23364439 2754523 Conversely , HTS activated p38 mitogen activated protein kinase (MAPK) and enhanced [TNF-a] *activation* of p38 . Positive_regulation TNF MAPK13 23557259 2777804 Inhibition of and CD137 signaling *reduce* dengue virus induced [TNF-a] secretion and apoptosis . Positive_regulation TNF MAPK13 23734186 2796927 Bla g 2 can stimulate up-regulation of inflammatory cytokines including [TNF-alpha] and IL-6 and *activation* of nuclear factor kappa B ( NF-kB/p65 ) , p38 ( p38 ) , ERK , and JNK in cultured fibrocytes . Positive_regulation TNF MAPK13 24089494 2848134 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed [TNF] receptor 1 and *requires* activation of p38 , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation TNF MAPK13 24441870 2922969 On the other hand , [TNF-a] could *induce* Akt and p42/p44 translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation TNF MAPK13 24750790 2936516 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas [TNFalpha] and NO production *required* all three . Positive_regulation TNF MAPK13 7722327 301744 [TNF-alpha] *induces* tyrosine phosphorylation of in adherent human neutrophils . Positive_regulation TNF MAPK13 7722327 301796 These results indicate that [TNF] signaling *involves* activation of . Positive_regulation TNF MAPK13 9148963 430051 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Positive_regulation TNF MAPK13 9418855 480528 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Positive_regulation TNF MAPK13 9439626 482882 These findings suggest a role for [TNF-alpha] in the regulation of intestinal epithelial cell growth and that the mitogenic effect of TNF-alpha *requires* protein tyrosine phosphorylation and activation . Positive_regulation TNF MAPK13 9551930 499080 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , IL-1beta , and [TNF-alpha] , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation TNF MAPK13 9706151 526174 We hypothesized that hydrogen peroxide ( H2O2 ) induces myocardial dysfunction and cardiomyocyte death via P38 *mediated* myocardial [tumor necrosis factor (TNF)] production . Positive_regulation TNF MAPK13 9730957 530346 However , in contrast to the wild-type endotoxin , it failed to induce significant production of [tumor necrosis factor-alpha] and macrophage inflammatory protein-1alpha by monocytes and did not *induce* the phosphorylation and nuclear translocation of . Positive_regulation TNF MAPK13 9766635 538490 [TNF-alpha] and GM-CSF priming of superoxide release stimulated by N-formyl-methionyl-leucyl-phenylalanine was significantly *attenuated* by the MEK inhibitor , PD098059 , and the p38 inhibitor , SB203580 . Positive_regulation TNF MAPK13 9864164 582562 A selective p38 inhibitor , SB203580 , *blocked* [TNF] -- or ceramide induced CREB phosphorylation , but had no effect on the induction of apoptosis mediated by these agents . Positive_regulation TNF MAPK13 9864164 582643 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Positive_regulation TNF MAPK13 9883899 558195 *Activation* of p42/p44 mitogen activated protein kinases (MAPK) and p38 by [tumor necrosis factor (TNF)] is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation TNF MAPK14 10079106 595510 Specific inhibitors of p38alpha *blocked* LPS induced adhesion , nuclear factor-kappa B (NF-kappaB) activation , and synthesis of [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF MAPK14 10079106 595564 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Positive_regulation TNF MAPK14 10079106 595577 These findings support a pathway by which LPS stimulation of neutrophils results in activation of MKK3 , which in turn activates p38alpha , ultimately regulating adhesion , NF-kappaB activation , *enhanced* gene expression of [TNF-alpha] , and regulation of TNF-alpha synthesis . Positive_regulation TNF MAPK14 10210635 607640 ( 1 ) The human heart produces TNF-alpha after I/R , ( 2 ) p38 *mediates* myocardial I/R induced [TNF-alpha] production , ( 3 ) p38 MAPK inhibition limits functional impairment after I/R , and ( 4 ) inhibition of ischemia induced TNF-alpha production may represent a potent therapeutic strategy for improving myocardial function after angioplasty , coronary bypass , or heart transplantation . Positive_regulation TNF MAPK14 10329111 613028 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Positive_regulation TNF MAPK14 10521481 653039 Engagement of tumor necrosis factor (TNF) receptor 1 leads to ATF-2- and p38 *dependent* [TNF-alpha] gene expression . Positive_regulation TNF MAPK14 10521481 653097 The study presented here shows that autoregulation of [TNF-alpha] gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation TNF MAPK14 10586056 571703 Ligation of microglial CD40 results in p44/42 *dependent* [TNF-alpha] production that is opposed by TGF-beta 1 and IL-10 . Positive_regulation TNF MAPK14 10586056 571757 Inhibition of the upstream activator of p44/42 , mitogen activated protein/extracellular signal related kinase kinase 1/2 , with PD98059 , decreases phosphorylation of p44/42 MAPK and significantly *reduces* [TNF-alpha] release following ligation of microglial CD40 . Positive_regulation TNF MAPK14 10601128 574176 [Tumor necrosis factor-alpha (TNF-alpha)] alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation TNF MAPK14 10620700 657670 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Positive_regulation TNF MAPK14 10653605 663295 These results suggest that ( 1 ) while PTK and are *essential* for the production of [TNFalpha] , they are not necessary for the induction of MnSOD by LPS , and ( 2 ) while activation of NFkappaB alone is insufficient for the induction of TNFalpha mRNA by LPS , it is necessary for the induction of TNFalpha as well as MnSOD mRNAs . Positive_regulation TNF MAPK14 10655266 663527 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Positive_regulation TNF MAPK14 10657669 664190 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Positive_regulation TNF MAPK14 10669634 665795 In this study , we show that [TNF-alpha] *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation TNF MAPK14 10783388 707823 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Positive_regulation TNF MAPK14 10857765 704534 These findings indicate that beta2-adrenoceptor stimulation during an LPS challenge prevented [TNF-alpha] production as a *consequence* of inhibition and enhanced cAMP generation , which at a later stage was associated with an anti-inflammatory effect of IL-6 . Positive_regulation TNF MAPK14 11076936 786253 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Positive_regulation TNF MAPK14 11153597 761140 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as [tumour necrosis factor-alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) , in vitro and in vivo by inhibiting p38 . Positive_regulation TNF MAPK14 11221891 787432 Kinase suppressor of ras is necessary for [tumor necrosis factor] alpha *activation* of extracellular signal regulated in intestinal epithelial cells . Positive_regulation TNF MAPK14 11221891 787458 activity is *essential* for [tumor necrosis factor (TNF)] alpha receptor 1 regulation of intestinal epithelial cell proliferation . Positive_regulation TNF MAPK14 11278471 802560 [Tumor necrosis factor-alpha] induction of endothelial ephrin A1 expression is *mediated* by a p38 and SAPK/JNK dependent but nuclear factor-kappa B-independent mechanism . Positive_regulation TNF MAPK14 11299196 803166 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Positive_regulation TNF MAPK14 11443053 833727 Finally , PD-98059 , a p42/44 pathway inhibitor , *blocked* [TNF-alpha] upregulation by eNOS ( P = 0.02 ) . Positive_regulation TNF MAPK14 11443055 833741 p38 *mediates* renal tubular cell [TNF-alpha] production and TNF-alpha dependent apoptosis during simulated ischemia . Positive_regulation TNF MAPK14 11443055 833781 Furthermore , 60 min of ischemia induced renal tubular cell apoptosis at all substrate replacement time points examined , with peak apoptotic cell death occurring after either 24 or 48 h . p38 MAPK inhibition abolished [TNF-alpha] mRNA production and TNF-alpha bioactivity , and both p38 inhibition and TNF-alpha neutralization ( anti-porcine TNF-alpha antibody ) *prevented* apoptosis after 60 min of SI . Positive_regulation TNF MAPK14 11443055 833794 These results constitute the initial demonstration that 1 ) renal tubular cells produce TNF-alpha mRNA and biologically active [TNF-alpha] and undergo apoptosis in response to SI , and 2 ) p38 *mediates* renal tubular cell TNF-alpha production and TNF-alpha dependent apoptosis after SI . Positive_regulation TNF MAPK14 11675371 873177 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Positive_regulation TNF MAPK14 11699878 878391 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Positive_regulation TNF MAPK14 11715476 581272 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Positive_regulation TNF MAPK14 11728947 884758 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Positive_regulation TNF MAPK14 11815388 907595 ( ERK ) blockade ( PD-98059 ) *attenuated* [TNF-alpha] secretion , an effect synergistically amplified in the presence of SB-203580 . Positive_regulation TNF MAPK14 11994432 938938 Evidence for a dual mechanism for IL-10 suppression of [TNF-alpha] production that does not *involve* inhibition of p38 or NF-kappa B in primary human macrophages . Positive_regulation TNF MAPK14 12130576 966550 Phosphorylation of p38 was *induced* by RANKL , IL-1 , [TNFalpha] , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation TNF MAPK14 12391245 1007384 Release of [TNF-alpha] , macrophage-inflammatory protein (MIP)-2 ( MIP-1beta ) , and IL-8 by LPS stimulated neutrophils was also *reduced* by poststimulation p38 inhibition . Positive_regulation TNF MAPK14 12392277 1007663 Inhibition of p38 with SB203580 *inhibited* the production of [TNF-alpha] and IL-10 by LPS stimulated KCs , whereas blockade of ERK1/2 with PD98059 could reduce TNF-alpha production , but did not affect IL-10 production . Positive_regulation TNF MAPK14 12393915 1025402 This model probiotic also inhibits *activation* of the pro-apoptotic by [tumor necrosis factor] , interleukin-1alpha , or gamma-interferon . Positive_regulation TNF MAPK14 12438325 1016565 The activation of protein tyrosine kinases (PTK) and the serine/threonine kinases p38 and ERK was apparently *required* for MTSA-10 induction of [TNF-alpha] and NO release , as revealed by specific kinase inhibitors . Positive_regulation TNF MAPK14 12506117 1056929 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Positive_regulation TNF MAPK14 12631113 1067652 The present data indicate that [TNF-alpha] *activation* of PKCzeta/iota , p42/44 , c-Jun/AP-1 , and p65/NF-kappaB are involved in TNF-alpha stimulated MC fractalkine expression , with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro . Positive_regulation TNF MAPK14 12637577 1099255 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and [tumor necrosis factor alpha (TNFalpha)] *requires* p38 activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation TNF MAPK14 12694807 1080898 [TNF-alpha] *induced* the phosphorylation of p44/p42 and p38 MAP kinase . Positive_regulation TNF MAPK14 12881424 1116119 Importantly , [TNF] does not *induce* ROS accumulation or prolonged activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death Positive_regulation TNF MAPK14 12969251 1139152 Inhibition of the MAP-kinase-kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) pathway , but not that of ( MAPK-p38 ) , *reduced* NO , [TNF-alpha] and IL-6 significantly , suggesting that simultaneous activation of the first two pathways is necessary for the AGE induced induction of these pro-inflammatory stimuli . Positive_regulation TNF MAPK14 14654378 1176815 These findings suggest that the pre-ischemic *activation* of by [TNF] does not contribute to cardioprotection afforded by this agent . Positive_regulation TNF MAPK14 14980980 1220294 The selective p38 inhibitor , SB203580 , *inhibited* the promoter activities of iNOS and COX-2 rather than that of [TNF-alpha] . Positive_regulation TNF MAPK14 15027449 1222852 Apoptosis caused by chronic ethanol treatment may be due to ethanol potentiation of [TNF] *induced* activation of p38 . Positive_regulation TNF MAPK14 15100302 1239720 Previous studies have shown the mitogen activated protein kinases ( MAPKs ) to be activated in macrophages upon infection with Mycobacterium , and that expression of [TNF-alpha] and inducible NO synthase by infected macrophages was *dependent* on activation . Positive_regulation TNF MAPK14 15139014 1246945 The increase in [TNF-alpha] release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation TNF MAPK14 15233873 1269378 A. semen also inhibited the expression of [TNF-alpha] and the *activation* of , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation TNF MAPK14 15248214 1271209 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of [TNFalpha] and IL-1beta by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation TNF MAPK14 15302094 1283838 Selective p42/44 inhibitor could *reduce* the Pb- and LPS triggered [TNF-alpha] expression in U-373MG cells . Positive_regulation TNF MAPK14 15557189 1340411 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Positive_regulation TNF MAPK14 15557189 1340437 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Positive_regulation TNF MAPK14 15592496 1375216 Tenascin-W is found in malignant mammary tumors , promotes alpha8 integrin dependent motility and *requires* activity for BMP-2 and [TNF-alpha] induced expression in vitro . Positive_regulation TNF MAPK14 15614136 1357463 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Positive_regulation TNF MAPK14 15701814 1416528 p38 activation *leads* to increased production of [TNF-alpha] in ischemic injury and in macrophages . Positive_regulation TNF MAPK14 15701814 1416555 Inhibition of p38 activation *led* to inhibition of [TNF-alpha] production . Positive_regulation TNF MAPK14 15703956 1497455 *Activation* of p38 and phosphatidylinositol 3-kinase (PI3K) by [TNF-alpha] was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation TNF MAPK14 15833800 1425439 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Positive_regulation TNF MAPK14 15867183 1404202 In cultured cardiac myocytes , specific activation of stress activated , p38 , by upstream activator MKK6bE *led* to significant induction of [tumor necrosis factor-alpha] and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation TNF MAPK14 15893422 1419732 We also investigated whether specific inhibition of p38 and Erk1/2 would *inhibit* [TNF-alpha] and IL-6 production and thus astrocyte apoptosis , and proliferation , respectively . Positive_regulation TNF MAPK14 15925386 1440373 Our observations show that calcium , activation , HIF-1alpha , and NF-kappaB are *necessary* for ethanol induced [TNF-alpha] and TGF-beta1 expression . Positive_regulation TNF MAPK14 16051807 1438611 Specific inhibitors of p38 significantly *reduced* the H5N1/97 induced [TNF-alpha] expression in macrophages . Positive_regulation TNF MAPK14 16081599 1460337 These results indicate that gp120 elicited [TNF-alpha] production by macrophages *involves* chemokine receptor mediated PI-3K and activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and ERK-1/2 independently regulate TNF-alpha production . Positive_regulation TNF MAPK14 16271232 1479205 Similarly , the increased gene expression of proinflammatory cytokines [TNF-alpha] and IL-1beta in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation TNF MAPK14 16275991 1480270 Angiotensin II , [tumor necrosis factor-alpha] , or epidermal growth factor *induced* phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation TNF MAPK14 16291729 1526055 *Activation* of and Akt by anti-HER2/neu [ScFv-TNF-alpha] inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation TNF MAPK14 16403817 1540128 The [TNF] + dex stimulated increase in leptin was associated with an increase in p38 MAPK activity and was totally *blocked* by p38 inhibitors . Positive_regulation TNF MAPK14 16438946 1495429 Although gAd partially increased cAMP concentration and PKA activity , it directly reduced leptin induced ERK1/2 and p38 phosphorylation thus *inhibiting* [TNF-alpha] production . Positive_regulation TNF MAPK14 16480618 1496067 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Positive_regulation TNF MAPK14 16480618 1496106 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Positive_regulation TNF MAPK14 16517732 1530905 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of [TNF] , but not IL-6 , *requires* the activity of p38 . Positive_regulation TNF MAPK14 16573652 1556124 HA-mediated [TNF-alpha] production *required* p38 , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation TNF MAPK14 16581537 1543738 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Positive_regulation TNF MAPK14 16596287 1544884 These results collectively reveal that AV-ext *inhibits* [TNF-alpha] release from macrophages by suppressing and NF-kappaB signaling pathways and suggest that AV-ext may be beneficial for the treatment of endotoxin shock or sepsis . Positive_regulation TNF MAPK14 16771851 1572707 this process then leads to modulation of p38 *dependent* IL-8 and [TNF-alpha] release from the epithelium . Positive_regulation TNF MAPK14 16781693 1585603 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and [TNF-alpha] and the *activation* of 's are potentially positive signals for IL-10 production . Positive_regulation TNF MAPK14 16867160 1592836 Further , the activation of p38 and extracellular signal regulated kinase was *required* for the induction of [TNF-alpha] and IL-6 by MTB12 , as well as by the 30-kDa Ag . Positive_regulation TNF MAPK14 17032936 1692724 The stimulation of [TNF-alpha] production was *dependent* on cisplatin induced activation of p38 and was associated with phosphorylation of the translation initiation factor eIF4E and its upstream kinase Mnk1 . Positive_regulation TNF MAPK14 17032936 1692737 Inhibition of p38 and , to a lesser extent , ERK , *reduced* cisplatin+endotoxin stimulated [TNF-alpha] production and phosphorylation of Mnk1 and eIF4E . Positive_regulation TNF MAPK14 17074860 1675545 B. burgdorferi induced [TNF-alpha] production is also *dependent* on the activation of p38 . Positive_regulation TNF MAPK14 17117477 1677357 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Positive_regulation TNF MAPK14 17126905 1686517 Differential regulation of [TNFalpha] and GM-CSF *induced* activation of P38 in neutrophils and eosinophils . Positive_regulation TNF MAPK14 17131360 1700731 In addition , we recently found that p38 *mediates* [TNF-alpha] upregulation of atrogin-1/MAFbx expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation TNF MAPK14 17138860 1653560 The purpose of this study was to determine whether the , ERK1/2 , and p38 MAPK are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Positive_regulation TNF MAPK14 17172975 1679374 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK14 17172975 1679400 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK14 17202326 1680802 Augmented lipopolysaccharide induced [TNF-alpha] production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK14 17202326 1680828 In this study , we show that augmented LPS induced [TNF-alpha] production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK14 17395780 1766149 Here we demonstrate that Rab7b can negatively regulate lipopolysaccharide (LPS) induced production of [tumor necrosis factor (TNF)-alpha] , IL-6 , nitric oxide , and IFN-beta , and potentiate LPS induced *activation* of , nuclear factor kappaB , and IFN regulatory factor 3 signaling pathways in macrophages by promoting the degradation of TLR4 . Positive_regulation TNF MAPK14 17438131 1742743 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by [TNF-alpha] and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation TNF MAPK14 17553937 1791995 Twenty-four hours thereafter , splenic macrophages were isolated , and their IL-6 and [TNF-alpha] production and *activation* of and NF-kappaB were measured . Positive_regulation TNF MAPK14 17607712 1798175 Although [TNF] *induced* the activation of p38 , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation TNF MAPK14 17902045 1835076 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Positive_regulation TNF MAPK14 17934341 1813483 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Positive_regulation TNF MAPK14 17940160 1888983 Conversely , Ser phosphorylation of IRS-2 mediated by [TNF-alpha] *activation* of was the mechanism found in brown adipocytes . Positive_regulation TNF MAPK14 17964662 1831049 Taken together , these results suggest that linomide *inhibits* [TNF-alpha] production by suppressing the activation of NF-kappaB and , which might , at least in part , contribute to the beneficial effects of linomide in the treatment of autoimmune diseases . Positive_regulation TNF MAPK14 17994109 1851144 [TNF-alpha] triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation TNF MAPK14 18227157 1884333 It was shown that these three proteins could ( i ) induce expression of [tumor necrosis factor alpha (TNF-alpha)] and tissue factor and ( ii ) *induce* phosphorylation of p44/42 and activation of early growth response factor 1 (Egr-1) . Positive_regulation TNF MAPK14 18296636 1878860 Whereas the induction of [TNFalpha] , IL-1beta , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation TNF MAPK14 18303184 1873523 Inhibition of p38 activation selectively *blocked* DNCB induced [TNF-alpha] release , but not NiSO ( 4 ) -induced release . Positive_regulation TNF MAPK14 18314537 1919433 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Positive_regulation TNF MAPK14 18390808 1925666 We tested the hypothesis that p38 activation is *necessary* for [TNF-alpha] production , neutrophil activation , and subsequent liver injury . Positive_regulation TNF MAPK14 18622138 1984358 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Positive_regulation TNF MAPK14 18675993 2011329 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Positive_regulation TNF MAPK14 19002259 1991231 Peptidoglycan stimulated monocyte p38 and p38 activity was *required* for [TNFalpha] production by the cells . Positive_regulation TNF MAPK14 19040616 2017407 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Positive_regulation TNF MAPK14 19043204 1998820 Moreover , [TNF-alpha] production was *prevented* by NF-kappaB and inhibitors . Positive_regulation TNF MAPK14 19052649 1999786 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Positive_regulation TNF MAPK14 19250666 2055377 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Positive_regulation TNF MAPK14 19267548 2045602 Since activated p38 *mediates* [TNF-alpha] production , we examined the effect of radiation on LPS induced activation of p38 MAPK and TNF-alpha production . Positive_regulation TNF MAPK14 19287189 2046604 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Positive_regulation TNF MAPK14 19351958 2088779 Specific inhibitors of p38 and glycogen synthase kinase 3 *suppressed* [TNF-alpha] production and maturation of fucoidan treated PBDCs . Positive_regulation TNF MAPK14 19427347 2106782 [TNF-alpha] *induced* the phosphorylation of p38 , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation TNF MAPK14 19477265 2107660 These results show that chronic ethanol feeding enhances Fas induced liver injury by a mechanism associated with induction of CYP2E1 , elevated serum [TNF-alpha] levels , and *activation* of . Positive_regulation TNF MAPK14 19493203 2091426 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Positive_regulation TNF MAPK14 19493203 2091452 In conclusion , our data indicate that signaling is *required* to induce maximal [TNF-alpha] production in macrophages during Orientia infection . Positive_regulation TNF MAPK14 19751557 2135276 p38MAPK 's phosphorylation is important in pathogenesis of MODS , and phosphorylation of can *enhance* TNF-alpha mRNA transcription and secretion of [TNF-alpha] from peripheral blood mononuclear cells , which is the mechanism of increased TNF-alpha in MODS . Positive_regulation TNF MAPK14 20010392 2175031 Because p38 ( p38 ) *upregulates* [TNF-alpha] expression and may play a crucial role in pain sensation , we investigated the effect of one injection of inhibitor on expression of the pain related neuropeptide calcitonin gene related peptide (CGRP) . Positive_regulation TNF MAPK14 20068037 2235131 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Positive_regulation TNF MAPK14 20083499 2380894 For the first time , we show that , in fish macrophages , [TNF-a] is processed by TACE-like activity and this cleavage is *dependent* upon the activation of ERK , and JNK signaling pathways by LPS . Positive_regulation TNF MAPK14 20499049 2276360 Expression of [TNF-alpha] and IL-6 in HMC-1 cells treated with bisphenol A is *attenuated* by plant originating glycoprotein ( 75 kDa ) by blocking p38 . Positive_regulation TNF MAPK14 20589681 2334364 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Positive_regulation TNF MAPK14 20646342 2292564 [TNF-alpha] *induced* a significant increase in p38 phosphorylation . Positive_regulation TNF MAPK14 20868379 2337169 [TNF-a] expression was *mediated* in a time dependent manner by p38 , activation of which is under the control of MKP1 . Positive_regulation TNF MAPK14 21208554 2374418 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Positive_regulation TNF MAPK14 21402598 2426928 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Positive_regulation TNF MAPK14 21545687 2554365 [Tumour necrosis factor-a (TNF-a)] significantly *induced* phosphorylation of p38 , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation TNF MAPK14 21642540 2446235 Pretreatment with TAT-SNAP-23 inhibited the increase in plasma membrane expression of gp91(phox) in TNF-a primed neutrophils , whereas [TNF-a] *activation* of ERK1/2 and p38 was not affected . Positive_regulation TNF MAPK14 21849907 2495992 All 3 inhibitors *suppressed* LPS induced [TNF-a] and I-309 expression in human primary monocytes . Positive_regulation TNF MAPK14 22002864 2526302 In this study , we found that inhibition of p38 with SB-203580 ( SB ) *reduced* H ( 2 ) O ( 2 ) -stimulated secretion of TNF-a , whereas pre-activation of p38 MAPK with sodium arsenite ( SA ) enhanced H ( 2 ) O ( 2 ) -stimulated secretion of [TNF-a] . Positive_regulation TNF MAPK14 22343222 2617761 Using immunohistological techniques , we showed a higher epithelial expression of [TNF-a] , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation TNF MAPK14 22385244 2566473 The use of selective inhibitors of signalling pathways revealed that induction of TG2 by IFN-? was mediated by phosphoinositide 3-kinase (PI3K) , while c-Jun N-terminal kinase (JNK) and p38 were *required* for [TNF-a] activation . Positive_regulation TNF MAPK14 22744777 2853447 After LPS administration , all animals displayed increased arterial carbon dioxide partial pressure ( PaCO2 ) and decreased arterial oxygen partial pressure ( PaO2 ) , arterial oxygen saturation ( SO2 ) , HCO3 ( - ) concentration and pH , and *increased* LWCI , MPO activity , interleukin (IL)-1ß , IL-6 and [tumor necrosis factor (TNF)-a] mRNA expression , NF-?B p65 positive staining and p38 activation compared with normal controls ( all P < 0.01 ) . Positive_regulation TNF MAPK14 23188524 2745410 We found that and Akt inhibitors , but not PI3K inhibitor , remarkably *suppressed* ACPA mediated [TNF-a] production . Positive_regulation TNF MAPK14 23354775 2769957 p38a may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , [tumor necrosis factor-a] , interleukin-1ß , and oxidative stress . Positive_regulation TNF MAPK14 23364439 2754524 Conversely , HTS activated p38 mitogen activated protein kinase (MAPK) and enhanced [TNF-a] *activation* of p38 . Positive_regulation TNF MAPK14 23557259 2777805 Inhibition of and CD137 signaling *reduce* dengue virus induced [TNF-a] secretion and apoptosis . Positive_regulation TNF MAPK14 23734186 2796928 Bla g 2 can stimulate up-regulation of inflammatory cytokines including [TNF-alpha] and IL-6 and *activation* of nuclear factor kappa B ( NF-kB/p65 ) , p38 ( p38 ) , ERK , and JNK in cultured fibrocytes . Positive_regulation TNF MAPK14 24089494 2848135 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed [TNF] receptor 1 and *requires* activation of p38 , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation TNF MAPK14 24441870 2922970 On the other hand , [TNF-a] could *induce* Akt and p42/p44 translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation TNF MAPK14 24750790 2936517 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas [TNFalpha] and NO production *required* all three . Positive_regulation TNF MAPK14 7722327 301745 [TNF-alpha] *induces* tyrosine phosphorylation of in adherent human neutrophils . Positive_regulation TNF MAPK14 7722327 301797 These results indicate that [TNF] signaling *involves* activation of . Positive_regulation TNF MAPK14 9148963 430052 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Positive_regulation TNF MAPK14 9418855 480529 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Positive_regulation TNF MAPK14 9439626 482883 These findings suggest a role for [TNF-alpha] in the regulation of intestinal epithelial cell growth and that the mitogenic effect of TNF-alpha *requires* protein tyrosine phosphorylation and activation . Positive_regulation TNF MAPK14 9551930 499081 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , IL-1beta , and [TNF-alpha] , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation TNF MAPK14 9706151 526175 We hypothesized that hydrogen peroxide ( H2O2 ) induces myocardial dysfunction and cardiomyocyte death via P38 *mediated* myocardial [tumor necrosis factor (TNF)] production . Positive_regulation TNF MAPK14 9730957 530347 However , in contrast to the wild-type endotoxin , it failed to induce significant production of [tumor necrosis factor-alpha] and macrophage inflammatory protein-1alpha by monocytes and did not *induce* the phosphorylation and nuclear translocation of . Positive_regulation TNF MAPK14 9766635 538491 [TNF-alpha] and GM-CSF priming of superoxide release stimulated by N-formyl-methionyl-leucyl-phenylalanine was significantly *attenuated* by the MEK inhibitor , PD098059 , and the p38 inhibitor , SB203580 . Positive_regulation TNF MAPK14 9864164 582563 A selective p38 inhibitor , SB203580 , *blocked* [TNF] -- or ceramide induced CREB phosphorylation , but had no effect on the induction of apoptosis mediated by these agents . Positive_regulation TNF MAPK14 9864164 582644 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Positive_regulation TNF MAPK14 9883899 558196 *Activation* of p42/p44 and p38 MAPK by [tumor necrosis factor (TNF)] is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation TNF MAPK15 10079106 595504 Specific inhibitors of p38alpha *blocked* LPS induced adhesion , nuclear factor-kappa B (NF-kappaB) activation , and synthesis of [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF MAPK15 10079106 595558 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Positive_regulation TNF MAPK15 10079106 595571 These findings support a pathway by which LPS stimulation of neutrophils results in activation of MKK3 , which in turn activates p38alpha , ultimately regulating adhesion , NF-kappaB activation , *enhanced* gene expression of [TNF-alpha] , and regulation of TNF-alpha synthesis . Positive_regulation TNF MAPK15 10210635 607634 ( 1 ) The human heart produces TNF-alpha after I/R , ( 2 ) p38 *mediates* myocardial I/R induced [TNF-alpha] production , ( 3 ) p38 MAPK inhibition limits functional impairment after I/R , and ( 4 ) inhibition of ischemia induced TNF-alpha production may represent a potent therapeutic strategy for improving myocardial function after angioplasty , coronary bypass , or heart transplantation . Positive_regulation TNF MAPK15 10329111 613021 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Positive_regulation TNF MAPK15 10521481 653033 Engagement of tumor necrosis factor (TNF) receptor 1 leads to ATF-2- and p38 *dependent* [TNF-alpha] gene expression . Positive_regulation TNF MAPK15 10521481 653090 The study presented here shows that autoregulation of [TNF-alpha] gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation TNF MAPK15 10586056 571697 Ligation of microglial CD40 results in p44/42 *dependent* [TNF-alpha] production that is opposed by TGF-beta 1 and IL-10 . Positive_regulation TNF MAPK15 10586056 571751 Inhibition of the upstream activator of p44/42 , mitogen activated protein/extracellular signal related kinase kinase 1/2 , with PD98059 , decreases phosphorylation of p44/42 MAPK and significantly *reduces* [TNF-alpha] release following ligation of microglial CD40 . Positive_regulation TNF MAPK15 10601128 574167 [Tumor necrosis factor-alpha (TNF-alpha)] alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation TNF MAPK15 10620700 657664 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Positive_regulation TNF MAPK15 10653605 663289 These results suggest that ( 1 ) while PTK and are *essential* for the production of [TNFalpha] , they are not necessary for the induction of MnSOD by LPS , and ( 2 ) while activation of NFkappaB alone is insufficient for the induction of TNFalpha mRNA by LPS , it is necessary for the induction of TNFalpha as well as MnSOD mRNAs . Positive_regulation TNF MAPK15 10655266 663520 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Positive_regulation TNF MAPK15 10657669 664184 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Positive_regulation TNF MAPK15 10669634 665789 In this study , we show that [TNF-alpha] *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation TNF MAPK15 10783388 707817 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Positive_regulation TNF MAPK15 10857765 704528 These findings indicate that beta2-adrenoceptor stimulation during an LPS challenge prevented [TNF-alpha] production as a *consequence* of inhibition and enhanced cAMP generation , which at a later stage was associated with an anti-inflammatory effect of IL-6 . Positive_regulation TNF MAPK15 11076936 786246 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Positive_regulation TNF MAPK15 11153597 761134 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as [tumour necrosis factor-alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) , in vitro and in vivo by inhibiting p38 . Positive_regulation TNF MAPK15 11221891 787425 Kinase suppressor of ras is necessary for [tumor necrosis factor] alpha *activation* of extracellular signal regulated in intestinal epithelial cells . Positive_regulation TNF MAPK15 11221891 787452 activity is *essential* for [tumor necrosis factor (TNF)] alpha receptor 1 regulation of intestinal epithelial cell proliferation . Positive_regulation TNF MAPK15 11278471 802554 [Tumor necrosis factor-alpha] induction of endothelial ephrin A1 expression is *mediated* by a p38 and SAPK/JNK dependent but nuclear factor-kappa B-independent mechanism . Positive_regulation TNF MAPK15 11299196 803160 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Positive_regulation TNF MAPK15 11443053 833721 Finally , PD-98059 , a p42/44 pathway inhibitor , *blocked* [TNF-alpha] upregulation by eNOS ( P = 0.02 ) . Positive_regulation TNF MAPK15 11443055 833735 p38 *mediates* renal tubular cell [TNF-alpha] production and TNF-alpha dependent apoptosis during simulated ischemia . Positive_regulation TNF MAPK15 11443055 833774 Furthermore , 60 min of ischemia induced renal tubular cell apoptosis at all substrate replacement time points examined , with peak apoptotic cell death occurring after either 24 or 48 h . p38 MAPK inhibition abolished [TNF-alpha] mRNA production and TNF-alpha bioactivity , and both p38 inhibition and TNF-alpha neutralization ( anti-porcine TNF-alpha antibody ) *prevented* apoptosis after 60 min of SI . Positive_regulation TNF MAPK15 11443055 833788 These results constitute the initial demonstration that 1 ) renal tubular cells produce TNF-alpha mRNA and biologically active [TNF-alpha] and undergo apoptosis in response to SI , and 2 ) p38 *mediates* renal tubular cell TNF-alpha production and TNF-alpha dependent apoptosis after SI . Positive_regulation TNF MAPK15 11675371 873171 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Positive_regulation TNF MAPK15 11699878 878385 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Positive_regulation TNF MAPK15 11715476 581266 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Positive_regulation TNF MAPK15 11728947 884752 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Positive_regulation TNF MAPK15 11815388 907589 ( ERK ) blockade ( PD-98059 ) *attenuated* [TNF-alpha] secretion , an effect synergistically amplified in the presence of SB-203580 . Positive_regulation TNF MAPK15 11994432 938932 Evidence for a dual mechanism for IL-10 suppression of [TNF-alpha] production that does not *involve* inhibition of p38 or NF-kappa B in primary human macrophages . Positive_regulation TNF MAPK15 12130576 966544 Phosphorylation of p38 was *induced* by RANKL , IL-1 , [TNFalpha] , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation TNF MAPK15 12391245 1007378 Release of [TNF-alpha] , macrophage-inflammatory protein (MIP)-2 ( MIP-1beta ) , and IL-8 by LPS stimulated neutrophils was also *reduced* by poststimulation p38 inhibition . Positive_regulation TNF MAPK15 12392277 1007657 Inhibition of p38 with SB203580 *inhibited* the production of [TNF-alpha] and IL-10 by LPS stimulated KCs , whereas blockade of ERK1/2 with PD98059 could reduce TNF-alpha production , but did not affect IL-10 production . Positive_regulation TNF MAPK15 12393915 1025396 This model probiotic also inhibits *activation* of the pro-apoptotic by [tumor necrosis factor] , interleukin-1alpha , or gamma-interferon . Positive_regulation TNF MAPK15 12438325 1016558 The activation of protein tyrosine kinases (PTK) and the serine/threonine kinases p38 and ERK was apparently *required* for MTSA-10 induction of [TNF-alpha] and NO release , as revealed by specific kinase inhibitors . Positive_regulation TNF MAPK15 12506117 1056923 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Positive_regulation TNF MAPK15 12631113 1067645 The present data indicate that [TNF-alpha] *activation* of PKCzeta/iota , p42/44 , c-Jun/AP-1 , and p65/NF-kappaB are involved in TNF-alpha stimulated MC fractalkine expression , with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro . Positive_regulation TNF MAPK15 12637577 1099248 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and [tumor necrosis factor alpha (TNFalpha)] *requires* p38 activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation TNF MAPK15 12694807 1080892 [TNF-alpha] *induced* the phosphorylation of p44/p42 and p38 MAP kinase . Positive_regulation TNF MAPK15 12881424 1116113 Importantly , [TNF] does not *induce* ROS accumulation or prolonged activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death Positive_regulation TNF MAPK15 12969251 1139145 Inhibition of the MAP-kinase-kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) pathway , but not that of ( MAPK-p38 ) , *reduced* NO , [TNF-alpha] and IL-6 significantly , suggesting that simultaneous activation of the first two pathways is necessary for the AGE induced induction of these pro-inflammatory stimuli . Positive_regulation TNF MAPK15 14654378 1176808 These findings suggest that the pre-ischemic *activation* of by [TNF] does not contribute to cardioprotection afforded by this agent . Positive_regulation TNF MAPK15 14980980 1220287 The selective p38 inhibitor , SB203580 , *inhibited* the promoter activities of iNOS and COX-2 rather than that of [TNF-alpha] . Positive_regulation TNF MAPK15 15027449 1222846 Apoptosis caused by chronic ethanol treatment may be due to ethanol potentiation of [TNF] *induced* activation of p38 . Positive_regulation TNF MAPK15 15100302 1239714 Previous studies have shown the mitogen activated protein kinases ( MAPKs ) to be activated in macrophages upon infection with Mycobacterium , and that expression of [TNF-alpha] and inducible NO synthase by infected macrophages was *dependent* on activation . Positive_regulation TNF MAPK15 15139014 1246939 The increase in [TNF-alpha] release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation TNF MAPK15 15233873 1269372 A. semen also inhibited the expression of [TNF-alpha] and the *activation* of , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation TNF MAPK15 15248214 1271203 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of [TNFalpha] and IL-1beta by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation TNF MAPK15 15302094 1283832 Selective p42/44 inhibitor could *reduce* the Pb- and LPS triggered [TNF-alpha] expression in U-373MG cells . Positive_regulation TNF MAPK15 15557189 1340405 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Positive_regulation TNF MAPK15 15557189 1340431 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Positive_regulation TNF MAPK15 15592496 1375210 Tenascin-W is found in malignant mammary tumors , promotes alpha8 integrin dependent motility and *requires* activity for BMP-2 and [TNF-alpha] induced expression in vitro . Positive_regulation TNF MAPK15 15614136 1357457 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Positive_regulation TNF MAPK15 15701814 1416521 p38 activation *leads* to increased production of [TNF-alpha] in ischemic injury and in macrophages . Positive_regulation TNF MAPK15 15701814 1416548 Inhibition of p38 activation *led* to inhibition of [TNF-alpha] production . Positive_regulation TNF MAPK15 15703956 1497449 *Activation* of p38 and phosphatidylinositol 3-kinase (PI3K) by [TNF-alpha] was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation TNF MAPK15 15833800 1425433 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Positive_regulation TNF MAPK15 15867183 1404194 In cultured cardiac myocytes , specific activation of stress activated , p38 , by upstream activator MKK6bE *led* to significant induction of [tumor necrosis factor-alpha] and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation TNF MAPK15 15893422 1419725 We also investigated whether specific inhibition of p38 and Erk1/2 would *inhibit* [TNF-alpha] and IL-6 production and thus astrocyte apoptosis , and proliferation , respectively . Positive_regulation TNF MAPK15 15925386 1440366 Our observations show that calcium , activation , HIF-1alpha , and NF-kappaB are *necessary* for ethanol induced [TNF-alpha] and TGF-beta1 expression . Positive_regulation TNF MAPK15 16051807 1438605 Specific inhibitors of p38 significantly *reduced* the H5N1/97 induced [TNF-alpha] expression in macrophages . Positive_regulation TNF MAPK15 16081599 1460330 These results indicate that gp120 elicited [TNF-alpha] production by macrophages *involves* chemokine receptor mediated PI-3K and activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and ERK-1/2 independently regulate TNF-alpha production . Positive_regulation TNF MAPK15 16271232 1479199 Similarly , the increased gene expression of proinflammatory cytokines [TNF-alpha] and IL-1beta in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation TNF MAPK15 16275991 1480264 Angiotensin II , [tumor necrosis factor-alpha] , or epidermal growth factor *induced* phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation TNF MAPK15 16291729 1526046 *Activation* of and Akt by anti-HER2/neu [ScFv-TNF-alpha] inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation TNF MAPK15 16403817 1540122 The [TNF] + dex stimulated increase in leptin was associated with an increase in p38 MAPK activity and was totally *blocked* by p38 inhibitors . Positive_regulation TNF MAPK15 16438946 1495423 Although gAd partially increased cAMP concentration and PKA activity , it directly reduced leptin induced ERK1/2 and p38 phosphorylation thus *inhibiting* [TNF-alpha] production . Positive_regulation TNF MAPK15 16480618 1496061 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Positive_regulation TNF MAPK15 16480618 1496100 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Positive_regulation TNF MAPK15 16517732 1530899 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of [TNF] , but not IL-6 , *requires* the activity of p38 . Positive_regulation TNF MAPK15 16573652 1556118 HA-mediated [TNF-alpha] production *required* p38 , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation TNF MAPK15 16581537 1543732 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Positive_regulation TNF MAPK15 16596287 1544878 These results collectively reveal that AV-ext *inhibits* [TNF-alpha] release from macrophages by suppressing and NF-kappaB signaling pathways and suggest that AV-ext may be beneficial for the treatment of endotoxin shock or sepsis . Positive_regulation TNF MAPK15 16771851 1572701 this process then leads to modulation of p38 *dependent* IL-8 and [TNF-alpha] release from the epithelium . Positive_regulation TNF MAPK15 16781693 1585597 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and [TNF-alpha] and the *activation* of 's are potentially positive signals for IL-10 production . Positive_regulation TNF MAPK15 16867160 1592830 Further , the activation of p38 and extracellular signal regulated kinase was *required* for the induction of [TNF-alpha] and IL-6 by MTB12 , as well as by the 30-kDa Ag . Positive_regulation TNF MAPK15 17032936 1692718 The stimulation of [TNF-alpha] production was *dependent* on cisplatin induced activation of p38 and was associated with phosphorylation of the translation initiation factor eIF4E and its upstream kinase Mnk1 . Positive_regulation TNF MAPK15 17032936 1692731 Inhibition of p38 and , to a lesser extent , ERK , *reduced* cisplatin+endotoxin stimulated [TNF-alpha] production and phosphorylation of Mnk1 and eIF4E . Positive_regulation TNF MAPK15 17074860 1675539 B. burgdorferi induced [TNF-alpha] production is also *dependent* on the activation of p38 . Positive_regulation TNF MAPK15 17117477 1677351 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Positive_regulation TNF MAPK15 17126905 1686511 Differential regulation of [TNFalpha] and GM-CSF *induced* activation of P38 in neutrophils and eosinophils . Positive_regulation TNF MAPK15 17131360 1700725 In addition , we recently found that p38 *mediates* [TNF-alpha] upregulation of atrogin-1/MAFbx expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation TNF MAPK15 17138860 1653554 The purpose of this study was to determine whether the , ERK1/2 , and p38 MAPK are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Positive_regulation TNF MAPK15 17172975 1679368 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK15 17172975 1679394 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK15 17202326 1680796 Augmented lipopolysaccharide induced [TNF-alpha] production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK15 17202326 1680822 In this study , we show that augmented LPS induced [TNF-alpha] production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK15 17395780 1766142 Here we demonstrate that Rab7b can negatively regulate lipopolysaccharide (LPS) induced production of [tumor necrosis factor (TNF)-alpha] , IL-6 , nitric oxide , and IFN-beta , and potentiate LPS induced *activation* of , nuclear factor kappaB , and IFN regulatory factor 3 signaling pathways in macrophages by promoting the degradation of TLR4 . Positive_regulation TNF MAPK15 17438131 1742737 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by [TNF-alpha] and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation TNF MAPK15 17553937 1791989 Twenty-four hours thereafter , splenic macrophages were isolated , and their IL-6 and [TNF-alpha] production and *activation* of and NF-kappaB were measured . Positive_regulation TNF MAPK15 17607712 1798168 Although [TNF] *induced* the activation of p38 , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation TNF MAPK15 17902045 1835070 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Positive_regulation TNF MAPK15 17934341 1813475 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Positive_regulation TNF MAPK15 17940160 1888977 Conversely , Ser phosphorylation of IRS-2 mediated by [TNF-alpha] *activation* of was the mechanism found in brown adipocytes . Positive_regulation TNF MAPK15 17964662 1831043 Taken together , these results suggest that linomide *inhibits* [TNF-alpha] production by suppressing the activation of NF-kappaB and , which might , at least in part , contribute to the beneficial effects of linomide in the treatment of autoimmune diseases . Positive_regulation TNF MAPK15 17994109 1851133 [TNF-alpha] triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation TNF MAPK15 18227157 1884326 It was shown that these three proteins could ( i ) induce expression of [tumor necrosis factor alpha (TNF-alpha)] and tissue factor and ( ii ) *induce* phosphorylation of p44/42 and activation of early growth response factor 1 (Egr-1) . Positive_regulation TNF MAPK15 18296636 1878853 Whereas the induction of [TNFalpha] , IL-1beta , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation TNF MAPK15 18303184 1873516 Inhibition of p38 activation selectively *blocked* DNCB induced [TNF-alpha] release , but not NiSO ( 4 ) -induced release . Positive_regulation TNF MAPK15 18314537 1919427 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Positive_regulation TNF MAPK15 18390808 1925660 We tested the hypothesis that p38 activation is *necessary* for [TNF-alpha] production , neutrophil activation , and subsequent liver injury . Positive_regulation TNF MAPK15 18622138 1984351 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Positive_regulation TNF MAPK15 18675993 2011323 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Positive_regulation TNF MAPK15 19002259 1991224 Peptidoglycan stimulated monocyte p38 and p38 activity was *required* for [TNFalpha] production by the cells . Positive_regulation TNF MAPK15 19040616 2017401 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Positive_regulation TNF MAPK15 19043204 1998814 Moreover , [TNF-alpha] production was *prevented* by NF-kappaB and inhibitors . Positive_regulation TNF MAPK15 19052649 1999780 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Positive_regulation TNF MAPK15 19250666 2055371 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Positive_regulation TNF MAPK15 19267548 2045596 Since activated p38 *mediates* [TNF-alpha] production , we examined the effect of radiation on LPS induced activation of p38 MAPK and TNF-alpha production . Positive_regulation TNF MAPK15 19287189 2046598 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Positive_regulation TNF MAPK15 19351958 2088773 Specific inhibitors of p38 and glycogen synthase kinase 3 *suppressed* [TNF-alpha] production and maturation of fucoidan treated PBDCs . Positive_regulation TNF MAPK15 19427347 2106776 [TNF-alpha] *induced* the phosphorylation of p38 , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation TNF MAPK15 19477265 2107654 These results show that chronic ethanol feeding enhances Fas induced liver injury by a mechanism associated with induction of CYP2E1 , elevated serum [TNF-alpha] levels , and *activation* of . Positive_regulation TNF MAPK15 19493203 2091420 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Positive_regulation TNF MAPK15 19493203 2091446 In conclusion , our data indicate that signaling is *required* to induce maximal [TNF-alpha] production in macrophages during Orientia infection . Positive_regulation TNF MAPK15 19751557 2135269 p38MAPK 's phosphorylation is important in pathogenesis of MODS , and phosphorylation of can *enhance* TNF-alpha mRNA transcription and secretion of [TNF-alpha] from peripheral blood mononuclear cells , which is the mechanism of increased TNF-alpha in MODS . Positive_regulation TNF MAPK15 20010392 2175025 Because p38 ( p38 ) *upregulates* [TNF-alpha] expression and may play a crucial role in pain sensation , we investigated the effect of one injection of inhibitor on expression of the pain related neuropeptide calcitonin gene related peptide (CGRP) . Positive_regulation TNF MAPK15 20068037 2235125 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Positive_regulation TNF MAPK15 20083499 2380887 For the first time , we show that , in fish macrophages , [TNF-a] is processed by TACE-like activity and this cleavage is *dependent* upon the activation of ERK , and JNK signaling pathways by LPS . Positive_regulation TNF MAPK15 20499049 2276354 Expression of [TNF-alpha] and IL-6 in HMC-1 cells treated with bisphenol A is *attenuated* by plant originating glycoprotein ( 75 kDa ) by blocking p38 . Positive_regulation TNF MAPK15 20589681 2334358 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Positive_regulation TNF MAPK15 20646342 2292558 [TNF-alpha] *induced* a significant increase in p38 phosphorylation . Positive_regulation TNF MAPK15 20868379 2337163 [TNF-a] expression was *mediated* in a time dependent manner by p38 , activation of which is under the control of MKP1 . Positive_regulation TNF MAPK15 21208554 2374412 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Positive_regulation TNF MAPK15 21402598 2426922 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Positive_regulation TNF MAPK15 21545687 2554356 [Tumour necrosis factor-a (TNF-a)] significantly *induced* phosphorylation of p38 , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation TNF MAPK15 21642540 2446229 Pretreatment with TAT-SNAP-23 inhibited the increase in plasma membrane expression of gp91(phox) in TNF-a primed neutrophils , whereas [TNF-a] *activation* of ERK1/2 and p38 was not affected . Positive_regulation TNF MAPK15 21849907 2495986 All 3 inhibitors *suppressed* LPS induced [TNF-a] and I-309 expression in human primary monocytes . Positive_regulation TNF MAPK15 22002864 2526296 In this study , we found that inhibition of p38 with SB-203580 ( SB ) *reduced* H ( 2 ) O ( 2 ) -stimulated secretion of [TNF-a] , whereas pre-activation of p38 MAPK with sodium arsenite ( SA ) enhanced H ( 2 ) O ( 2 ) -stimulated secretion of TNF-a . Positive_regulation TNF MAPK15 22343222 2617754 Using immunohistological techniques , we showed a higher epithelial expression of [TNF-a] , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation TNF MAPK15 22385244 2566466 The use of selective inhibitors of signalling pathways revealed that induction of TG2 by IFN-? was mediated by phosphoinositide 3-kinase (PI3K) , while c-Jun N-terminal kinase (JNK) and p38 were *required* for [TNF-a] activation . Positive_regulation TNF MAPK15 22744777 2853440 After LPS administration , all animals displayed increased arterial carbon dioxide partial pressure ( PaCO2 ) and decreased arterial oxygen partial pressure ( PaO2 ) , arterial oxygen saturation ( SO2 ) , HCO3 ( - ) concentration and pH , and *increased* LWCI , MPO activity , interleukin (IL)-1ß , IL-6 and [tumor necrosis factor (TNF)-a] mRNA expression , NF-?B p65 positive staining and p38 activation compared with normal controls ( all P < 0.01 ) . Positive_regulation TNF MAPK15 23188524 2745401 We found that and Akt inhibitors , but not PI3K inhibitor , remarkably *suppressed* ACPA mediated [TNF-a] production . Positive_regulation TNF MAPK15 23354775 2769951 p38a may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , [tumor necrosis factor-a] , interleukin-1ß , and oxidative stress . Positive_regulation TNF MAPK15 23364439 2754518 Conversely , HTS activated p38 mitogen activated protein kinase (MAPK) and enhanced [TNF-a] *activation* of p38 . Positive_regulation TNF MAPK15 23557259 2777799 Inhibition of and CD137 signaling *reduce* dengue virus induced [TNF-a] secretion and apoptosis . Positive_regulation TNF MAPK15 23734186 2796921 Bla g 2 can stimulate up-regulation of inflammatory cytokines including [TNF-alpha] and IL-6 and *activation* of nuclear factor kappa B ( NF-kB/p65 ) , p38 ( p38 ) , ERK , and JNK in cultured fibrocytes . Positive_regulation TNF MAPK15 24089494 2848129 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed [TNF] receptor 1 and *requires* activation of p38 , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation TNF MAPK15 24441870 2922961 On the other hand , [TNF-a] could *induce* Akt and p42/p44 translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation TNF MAPK15 24750790 2936511 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas [TNFalpha] and NO production *required* all three . Positive_regulation TNF MAPK15 7722327 301739 [TNF-alpha] *induces* tyrosine phosphorylation of in adherent human neutrophils . Positive_regulation TNF MAPK15 7722327 301791 These results indicate that [TNF] signaling *involves* activation of . Positive_regulation TNF MAPK15 9148963 430046 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Positive_regulation TNF MAPK15 9418855 480523 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Positive_regulation TNF MAPK15 9439626 482877 These findings suggest a role for [TNF-alpha] in the regulation of intestinal epithelial cell growth and that the mitogenic effect of TNF-alpha *requires* protein tyrosine phosphorylation and activation . Positive_regulation TNF MAPK15 9551930 499075 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , IL-1beta , and [TNF-alpha] , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation TNF MAPK15 9706151 526168 We hypothesized that hydrogen peroxide ( H2O2 ) induces myocardial dysfunction and cardiomyocyte death via P38 *mediated* myocardial [tumor necrosis factor (TNF)] production . Positive_regulation TNF MAPK15 9730957 530341 However , in contrast to the wild-type endotoxin , it failed to induce significant production of [tumor necrosis factor-alpha] and macrophage inflammatory protein-1alpha by monocytes and did not *induce* the phosphorylation and nuclear translocation of . Positive_regulation TNF MAPK15 9766635 538477 [TNF-alpha] and GM-CSF priming of superoxide release stimulated by N-formyl-methionyl-leucyl-phenylalanine was significantly *attenuated* by the MEK inhibitor , PD098059 , and the p38 inhibitor , SB203580 . Positive_regulation TNF MAPK15 9864164 582556 A selective p38 inhibitor , SB203580 , *blocked* [TNF] -- or ceramide induced CREB phosphorylation , but had no effect on the induction of apoptosis mediated by these agents . Positive_regulation TNF MAPK15 9864164 582638 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Positive_regulation TNF MAPK15 9883899 558190 *Activation* of p42/p44 and p38 MAPK by [tumor necrosis factor (TNF)] is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation TNF MAPK3 10079106 595511 Specific inhibitors of p38alpha *blocked* LPS induced adhesion , nuclear factor-kappa B (NF-kappaB) activation , and synthesis of [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF MAPK3 10079106 595565 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Positive_regulation TNF MAPK3 10079106 595578 These findings support a pathway by which LPS stimulation of neutrophils results in activation of MKK3 , which in turn activates p38alpha , ultimately regulating adhesion , NF-kappaB activation , *enhanced* gene expression of [TNF-alpha] , and regulation of TNF-alpha synthesis . Positive_regulation TNF MAPK3 10210635 607641 ( 1 ) The human heart produces TNF-alpha after I/R , ( 2 ) p38 *mediates* myocardial I/R induced [TNF-alpha] production , ( 3 ) p38 MAPK inhibition limits functional impairment after I/R , and ( 4 ) inhibition of ischemia induced TNF-alpha production may represent a potent therapeutic strategy for improving myocardial function after angioplasty , coronary bypass , or heart transplantation . Positive_regulation TNF MAPK3 10329111 613029 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Positive_regulation TNF MAPK3 10521481 653040 Engagement of tumor necrosis factor (TNF) receptor 1 leads to ATF-2- and p38 *dependent* [TNF-alpha] gene expression . Positive_regulation TNF MAPK3 10521481 653098 The study presented here shows that autoregulation of [TNF-alpha] gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation TNF MAPK3 10586056 571704 Ligation of microglial CD40 results in p44/42 *dependent* [TNF-alpha] production that is opposed by TGF-beta 1 and IL-10 . Positive_regulation TNF MAPK3 10586056 571758 Inhibition of the upstream activator of p44/42 , mitogen activated protein/extracellular signal related kinase kinase 1/2 , with PD98059 , decreases phosphorylation of p44/42 MAPK and significantly *reduces* [TNF-alpha] release following ligation of microglial CD40 . Positive_regulation TNF MAPK3 10601128 574177 [Tumor necrosis factor-alpha (TNF-alpha)] alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation TNF MAPK3 10620700 657671 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Positive_regulation TNF MAPK3 10653605 663296 These results suggest that ( 1 ) while PTK and are *essential* for the production of [TNFalpha] , they are not necessary for the induction of MnSOD by LPS , and ( 2 ) while activation of NFkappaB alone is insufficient for the induction of TNFalpha mRNA by LPS , it is necessary for the induction of TNFalpha as well as MnSOD mRNAs . Positive_regulation TNF MAPK3 10655266 663528 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Positive_regulation TNF MAPK3 10657669 664191 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Positive_regulation TNF MAPK3 10669634 665796 In this study , we show that [TNF-alpha] *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation TNF MAPK3 10783388 707824 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Positive_regulation TNF MAPK3 10857765 704535 These findings indicate that beta2-adrenoceptor stimulation during an LPS challenge prevented [TNF-alpha] production as a *consequence* of inhibition and enhanced cAMP generation , which at a later stage was associated with an anti-inflammatory effect of IL-6 . Positive_regulation TNF MAPK3 10913368 716279 *Activation* of and cPLA(2) by the p55 [TNF] receptor occurs independently of FAN . Positive_regulation TNF MAPK3 11034403 740724 Although exogenous hsp27 stimulation activated all three monocyte mitogen activated protein kinase pathways ( extracellular signal related kinase ( ERK ) 1/2 , c-Jun N-terminal kinase , and p38 ) , only p38 activation was sustained and required for hsp27 induction of monocyte IL-10 , while both and p38 activation were *required* for induction of [TNF-alpha] when using the p38 inhibitor SB203580 or the ERK inhibitor PD98059 . Positive_regulation TNF MAPK3 11076936 786254 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Positive_regulation TNF MAPK3 11153597 761141 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as [tumour necrosis factor-alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) , in vitro and in vivo by inhibiting p38 . Positive_regulation TNF MAPK3 11221891 787433 Kinase suppressor of ras is necessary for [tumor necrosis factor] alpha *activation* of extracellular signal regulated in intestinal epithelial cells . Positive_regulation TNF MAPK3 11221891 787459 activity is *essential* for [tumor necrosis factor (TNF)] alpha receptor 1 regulation of intestinal epithelial cell proliferation . Positive_regulation TNF MAPK3 11278471 802561 [Tumor necrosis factor-alpha] induction of endothelial ephrin A1 expression is *mediated* by a p38 and SAPK/JNK dependent but nuclear factor-kappa B-independent mechanism . Positive_regulation TNF MAPK3 11299196 803167 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Positive_regulation TNF MAPK3 11353829 815142 Fluid shear stress inhibits [TNF-alpha] *activation* of JNK but not or p38 in human umbilical vein endothelial cells : Inhibitory crosstalk among MAPK family members . Positive_regulation TNF MAPK3 11443053 833728 Finally , PD-98059 , a p42/44 pathway inhibitor , *blocked* [TNF-alpha] upregulation by eNOS ( P = 0.02 ) . Positive_regulation TNF MAPK3 11443055 833742 p38 *mediates* renal tubular cell [TNF-alpha] production and TNF-alpha dependent apoptosis during simulated ischemia . Positive_regulation TNF MAPK3 11443055 833782 Furthermore , 60 min of ischemia induced renal tubular cell apoptosis at all substrate replacement time points examined , with peak apoptotic cell death occurring after either 24 or 48 h . p38 MAPK inhibition abolished [TNF-alpha] mRNA production and TNF-alpha bioactivity , and both p38 inhibition and TNF-alpha neutralization ( anti-porcine TNF-alpha antibody ) *prevented* apoptosis after 60 min of SI . Positive_regulation TNF MAPK3 11443055 833795 These results constitute the initial demonstration that 1 ) renal tubular cells produce TNF-alpha mRNA and biologically active [TNF-alpha] and undergo apoptosis in response to SI , and 2 ) p38 *mediates* renal tubular cell TNF-alpha production and TNF-alpha dependent apoptosis after SI . Positive_regulation TNF MAPK3 11675371 873178 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Positive_regulation TNF MAPK3 11689211 876144 [TNFalpha] *induced* activation in both cell types . Positive_regulation TNF MAPK3 11699878 878392 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Positive_regulation TNF MAPK3 11715476 581273 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Positive_regulation TNF MAPK3 11728947 884759 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Positive_regulation TNF MAPK3 11751152 898187 and Egr-1 *contribute* to increased [TNF-alpha] production in rat Kupffer cells after chronic ethanol feeding . Positive_regulation TNF MAPK3 11751152 898188 Activation of was *required* for maximal increases in [TNF-alpha] and IL-1beta mRNA and was associated with increased binding of early growth response-1 (Egr-1) to the TNF-alpha promoter after ethanol feeding . Positive_regulation TNF MAPK3 11751152 898190 Together , these data suggest that enhanced activation of and Egr-1 *contributes* to increased [TNF-alpha] production after chronic ethanol feeding . Positive_regulation TNF MAPK3 11815388 907596 ( ERK ) blockade ( PD-98059 ) *attenuated* [TNF-alpha] secretion , an effect synergistically amplified in the presence of SB-203580 . Positive_regulation TNF MAPK3 11856733 929522 Increased Egr-1 promoter activity and [TNFalpha] mRNA accumulation after chronic ethanol were both *prevented* by overexpression of dominant negative . Positive_regulation TNF MAPK3 11994432 938939 Evidence for a dual mechanism for IL-10 suppression of [TNF-alpha] production that does not *involve* inhibition of p38 or NF-kappa B in primary human macrophages . Positive_regulation TNF MAPK3 11997234 939275 However , the *role* of activation in mediating LPS stimulated [TNF-alpha] production is not well understood . Positive_regulation TNF MAPK3 12130576 966551 Phosphorylation of p38 was *induced* by RANKL , IL-1 , [TNFalpha] , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation TNF MAPK3 12133965 967056 Selective inhibitors of ( PD98059 or U0126 ) , p38 ( SB203580 ) , or NF-kappa B ( caffeic acid phenetyl ester ( CAPE ) ) could all significantly *reduce* [TNF-alpha] production , although none of the inhibitors used alone was able to completely prevent TNF-alpha release . Positive_regulation TNF MAPK3 12391245 1007385 Release of [TNF-alpha] , macrophage-inflammatory protein (MIP)-2 ( MIP-1beta ) , and IL-8 by LPS stimulated neutrophils was also *reduced* by poststimulation p38 inhibition . Positive_regulation TNF MAPK3 12392277 1007664 Inhibition of p38 with SB203580 *inhibited* the production of [TNF-alpha] and IL-10 by LPS stimulated KCs , whereas blockade of ERK1/2 with PD98059 could reduce TNF-alpha production , but did not affect IL-10 production . Positive_regulation TNF MAPK3 12393915 1025403 This model probiotic also inhibits *activation* of the pro-apoptotic by [tumor necrosis factor] , interleukin-1alpha , or gamma-interferon . Positive_regulation TNF MAPK3 12438325 1016566 The activation of protein tyrosine kinases (PTK) and the serine/threonine kinases p38 and ERK was apparently *required* for MTSA-10 induction of [TNF-alpha] and NO release , as revealed by specific kinase inhibitors . Positive_regulation TNF MAPK3 12506117 1056930 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Positive_regulation TNF MAPK3 12526087 1028231 [TNF-alpha] does not *induce* phosphorylation of and S727 in ECV304 and smooth muscle cells . Positive_regulation TNF MAPK3 12631113 1067653 The present data indicate that [TNF-alpha] *activation* of PKCzeta/iota , p42/44 , c-Jun/AP-1 , and p65/NF-kappaB are involved in TNF-alpha stimulated MC fractalkine expression , with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro . Positive_regulation TNF MAPK3 12637577 1099256 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and [tumor necrosis factor alpha (TNFalpha)] *requires* p38 activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation TNF MAPK3 12694807 1080899 [TNF-alpha] *induced* the phosphorylation of p44/p42 and p38 MAP kinase . Positive_regulation TNF MAPK3 12734378 1087355 Our results indicate that A beta induced expression of cytokines ( [TNF-alpha] and IL-1 beta ) and chemokines ( MCP-1 , IL-8 , and MIP-1 beta ) in THP-1 monocytes *involves* activation of and downstream activation of Egr-1 . Positive_regulation TNF MAPK3 12881424 1116120 Importantly , [TNF] does not *induce* ROS accumulation or prolonged activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death Positive_regulation TNF MAPK3 12969251 1139153 Inhibition of the MAP-kinase-kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) pathway , but not that of ( MAPK-p38 ) , *reduced* NO , [TNF-alpha] and IL-6 significantly , suggesting that simultaneous activation of the first two pathways is necessary for the AGE induced induction of these pro-inflammatory stimuli . Positive_regulation TNF MAPK3 14654378 1176816 These findings suggest that the pre-ischemic *activation* of by [TNF] does not contribute to cardioprotection afforded by this agent . Positive_regulation TNF MAPK3 14980980 1220295 The selective p38 inhibitor , SB203580 , *inhibited* the promoter activities of iNOS and COX-2 rather than that of [TNF-alpha] . Positive_regulation TNF MAPK3 15027449 1222853 Apoptosis caused by chronic ethanol treatment may be due to ethanol potentiation of [TNF] *induced* activation of p38 . Positive_regulation TNF MAPK3 15100302 1239721 Previous studies have shown the mitogen activated protein kinases ( MAPKs ) to be activated in macrophages upon infection with Mycobacterium , and that expression of [TNF-alpha] and inducible NO synthase by infected macrophages was *dependent* on activation . Positive_regulation TNF MAPK3 15139014 1246946 The increase in [TNF-alpha] release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation TNF MAPK3 15233873 1269379 A. semen also inhibited the expression of [TNF-alpha] and the *activation* of , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation TNF MAPK3 15248214 1271210 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of [TNFalpha] and IL-1beta by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation TNF MAPK3 15302094 1283839 Selective p42/44 inhibitor could *reduce* the Pb- and LPS triggered [TNF-alpha] expression in U-373MG cells . Positive_regulation TNF MAPK3 15365619 1334210 Rosiglitazone treatment impaired [TNF-alpha] *activation* of p38 and , restoring insulin signalling and leading to normalisation of glucose uptake . Positive_regulation TNF MAPK3 15557189 1340412 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Positive_regulation TNF MAPK3 15557189 1340438 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Positive_regulation TNF MAPK3 15592496 1375217 Tenascin-W is found in malignant mammary tumors , promotes alpha8 integrin dependent motility and *requires* activity for BMP-2 and [TNF-alpha] induced expression in vitro . Positive_regulation TNF MAPK3 15611271 1357354 However , inhibitors of serine/threonine protein phosphatase type 1 and type 2A significantly increased IL-6 and [TNF-alpha] levels , and prolonged *activation* of p38 and when triggered by TLR4 and TLR9 ligands . Positive_regulation TNF MAPK3 15614136 1357464 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Positive_regulation TNF MAPK3 15618191 1357638 The [TNF-alpha] production was *dependent* on both p38 and ( ERK 1/2 ) activation . Positive_regulation TNF MAPK3 15701814 1416529 p38 activation *leads* to increased production of [TNF-alpha] in ischemic injury and in macrophages . Positive_regulation TNF MAPK3 15701814 1416556 Inhibition of p38 activation *led* to inhibition of [TNF-alpha] production . Positive_regulation TNF MAPK3 15703956 1497456 *Activation* of p38 and phosphatidylinositol 3-kinase (PI3K) by [TNF-alpha] was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation TNF MAPK3 15833800 1425440 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Positive_regulation TNF MAPK3 15867183 1404203 In cultured cardiac myocytes , specific activation of stress activated , p38 , by upstream activator MKK6bE *led* to significant induction of [tumor necrosis factor-alpha] and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation TNF MAPK3 15893422 1419733 We also investigated whether specific inhibition of p38 and Erk1/2 would *inhibit* [TNF-alpha] and IL-6 production and thus astrocyte apoptosis , and proliferation , respectively . Positive_regulation TNF MAPK3 15893422 1419757 In contrast , inhibition of both p38 and significantly *diminished* [TNF-alpha] production , and totally abrogated production of this cytokine when both MAPK pathways were inhibited simultaneously . Positive_regulation TNF MAPK3 15925386 1440374 Our observations show that calcium , activation , HIF-1alpha , and NF-kappaB are *necessary* for ethanol induced [TNF-alpha] and TGF-beta1 expression . Positive_regulation TNF MAPK3 15979106 1459096 The involvement of this nucleoside in the *activation* of by [TNF-alpha] was also investigated . Positive_regulation TNF MAPK3 16051807 1438612 Specific inhibitors of p38 significantly *reduced* the H5N1/97 induced [TNF-alpha] expression in macrophages . Positive_regulation TNF MAPK3 16081599 1460338 These results indicate that gp120 elicited [TNF-alpha] production by macrophages *involves* chemokine receptor mediated PI-3K and activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and ERK-1/2 independently regulate TNF-alpha production . Positive_regulation TNF MAPK3 16177323 1458113 This correlated with the *requirement* for in [TNF-alpha] but not NOS2 promoter activity . Positive_regulation TNF MAPK3 16177323 1458121 Our data indicate that the increased Ets/Elk and NF-kappaB promoter activities associated with M. smegmatis infected macrophages are responsible , at least in part , for the increased [TNF-alpha] and NOS2 production observed in these infected cells and that is *required* for Ets/Elk activity and full TNF-alpha production . Positive_regulation TNF MAPK3 16188954 1500823 Activation of the adenosine A3 receptor in RAW 264.7 cells *inhibits* lipopolysaccharide stimulated [tumor necrosis factor-alpha] release by reducing calcium dependent activation of nuclear factor-kappaB and . Positive_regulation TNF MAPK3 16271232 1479206 Similarly , the increased gene expression of proinflammatory cytokines [TNF-alpha] and IL-1beta in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation TNF MAPK3 16275991 1480271 Angiotensin II , [tumor necrosis factor-alpha] , or epidermal growth factor *induced* phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation TNF MAPK3 16291729 1526056 *Activation* of and Akt by anti-HER2/neu [ScFv-TNF-alpha] inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation TNF MAPK3 16403817 1540129 The [TNF] + dex stimulated increase in leptin was associated with an increase in p38 MAPK activity and was totally *blocked* by p38 inhibitors . Positive_regulation TNF MAPK3 16438946 1495430 Although gAd partially increased cAMP concentration and PKA activity , it directly reduced leptin induced ERK1/2 and p38 phosphorylation thus *inhibiting* [TNF-alpha] production . Positive_regulation TNF MAPK3 16442440 1516897 We now define distinct signaling pathways that regulate induction of [TNF-alpha] and *activation* of by intracellular signaling mechanisms during M. bovis infection . Positive_regulation TNF MAPK3 16480618 1496068 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Positive_regulation TNF MAPK3 16480618 1496107 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Positive_regulation TNF MAPK3 16517732 1530906 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of [TNF] , but not IL-6 , *requires* the activity of p38 . Positive_regulation TNF MAPK3 16573652 1556125 HA-mediated [TNF-alpha] production *required* p38 , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation TNF MAPK3 16581537 1543739 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Positive_regulation TNF MAPK3 16596287 1544885 These results collectively reveal that AV-ext *inhibits* [TNF-alpha] release from macrophages by suppressing and NF-kappaB signaling pathways and suggest that AV-ext may be beneficial for the treatment of endotoxin shock or sepsis . Positive_regulation TNF MAPK3 16622205 1551607 [ERK1/2 ] and p38 ) and *induces* [tumor necrosis factor alpha (TNF-alpha)] and interleukin 6 (IL-6) in human monocytes . Positive_regulation TNF MAPK3 16771851 1572708 this process then leads to modulation of p38 *dependent* IL-8 and [TNF-alpha] release from the epithelium . Positive_regulation TNF MAPK3 16781693 1585604 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and [TNF-alpha] and the *activation* of 's are potentially positive signals for IL-10 production . Positive_regulation TNF MAPK3 16867160 1592837 Further , the activation of p38 and extracellular signal regulated kinase was *required* for the induction of [TNF-alpha] and IL-6 by MTB12 , as well as by the 30-kDa Ag . Positive_regulation TNF MAPK3 17032936 1692725 The stimulation of [TNF-alpha] production was *dependent* on cisplatin induced activation of p38 and was associated with phosphorylation of the translation initiation factor eIF4E and its upstream kinase Mnk1 . Positive_regulation TNF MAPK3 17032936 1692738 Inhibition of p38 and , to a lesser extent , ERK , *reduced* cisplatin+endotoxin stimulated [TNF-alpha] production and phosphorylation of Mnk1 and eIF4E . Positive_regulation TNF MAPK3 17059425 1683923 Zoledronate reduced Ras prenylation , Ras and RhoA translocation to the membrane , and sustained phosphorylation and [tumor necrosis factor (TNF)] *induced* JNK phosphorylation . Positive_regulation TNF MAPK3 17074860 1675546 B. burgdorferi induced [TNF-alpha] production is also *dependent* on the activation of p38 . Positive_regulation TNF MAPK3 17117477 1677358 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Positive_regulation TNF MAPK3 17126905 1686518 Differential regulation of [TNFalpha] and GM-CSF *induced* activation of P38 in neutrophils and eosinophils . Positive_regulation TNF MAPK3 17131360 1700732 In addition , we recently found that p38 *mediates* [TNF-alpha] upregulation of atrogin-1/MAFbx expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation TNF MAPK3 17138860 1653561 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Positive_regulation TNF MAPK3 17172975 1679375 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK3 17172975 1679401 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK3 17202326 1680803 Augmented lipopolysaccharide induced [TNF-alpha] production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK3 17202326 1680829 In this study , we show that augmented LPS induced [TNF-alpha] production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK3 17276429 1697765 Moreover , only inhibition by U0126 *suppressed* PA-induced [TNF-alpha] production and MMP-9 expression . Positive_regulation TNF MAPK3 17348859 1733935 We also show that MDP activates ( extracellular-signal regulated kinase 1 ) /ERK2 and p38alpha MAPK in human peripheral-blood mononuclear cells and that the activity of both MAPKs and TAK1 are *required* for MDP induced signalling and production of IL-1beta and [TNFalpha] in these cells . Positive_regulation TNF MAPK3 17395780 1766150 Here we demonstrate that Rab7b can negatively regulate lipopolysaccharide (LPS) induced production of [tumor necrosis factor (TNF)-alpha] , IL-6 , nitric oxide , and IFN-beta , and potentiate LPS induced *activation* of , nuclear factor kappaB , and IFN regulatory factor 3 signaling pathways in macrophages by promoting the degradation of TLR4 . Positive_regulation TNF MAPK3 17438131 1742744 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by [TNF-alpha] and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation TNF MAPK3 17537727 1767292 Inhibition of with U0126 potently *suppressed* gAcrp stimulated Egr-1 promoter activity , as well as [TNF-alpha] promoter activity . Positive_regulation TNF MAPK3 17553937 1791996 Twenty-four hours thereafter , splenic macrophages were isolated , and their IL-6 and [TNF-alpha] production and *activation* of and NF-kappaB were measured . Positive_regulation TNF MAPK3 17607712 1798176 Although [TNF] *induced* the activation of p38 , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation TNF MAPK3 17902045 1835077 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Positive_regulation TNF MAPK3 17934341 1813484 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Positive_regulation TNF MAPK3 17940160 1888984 Conversely , Ser phosphorylation of IRS-2 mediated by [TNF-alpha] *activation* of was the mechanism found in brown adipocytes . Positive_regulation TNF MAPK3 17964662 1831050 Taken together , these results suggest that linomide *inhibits* [TNF-alpha] production by suppressing the activation of NF-kappaB and , which might , at least in part , contribute to the beneficial effects of linomide in the treatment of autoimmune diseases . Positive_regulation TNF MAPK3 17994109 1851145 [TNF-alpha] triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation TNF MAPK3 18177344 1869952 inhibitor PD98059 *blocked* both [TNF-alpha] and IL-1beta , but not IL-6 production . Positive_regulation TNF MAPK3 18227157 1884334 It was shown that these three proteins could ( i ) induce expression of [tumor necrosis factor alpha (TNF-alpha)] and tissue factor and ( ii ) *induce* phosphorylation of p44/42 and activation of early growth response factor 1 (Egr-1) . Positive_regulation TNF MAPK3 18296636 1878861 Whereas the induction of [TNFalpha] , IL-1beta , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation TNF MAPK3 18303184 1873524 Inhibition of p38 activation selectively *blocked* DNCB induced [TNF-alpha] release , but not NiSO ( 4 ) -induced release . Positive_regulation TNF MAPK3 18314537 1919434 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Positive_regulation TNF MAPK3 18390808 1925667 We tested the hypothesis that p38 activation is *necessary* for [TNF-alpha] production , neutrophil activation , and subsequent liver injury . Positive_regulation TNF MAPK3 18622138 1984359 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Positive_regulation TNF MAPK3 18675993 2011330 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Positive_regulation TNF MAPK3 19002259 1991232 Peptidoglycan stimulated monocyte p38 and p38 activity was *required* for [TNFalpha] production by the cells . Positive_regulation TNF MAPK3 19040616 2017408 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Positive_regulation TNF MAPK3 19043204 1998821 Moreover , [TNF-alpha] production was *prevented* by NF-kappaB and inhibitors . Positive_regulation TNF MAPK3 19052649 1999787 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Positive_regulation TNF MAPK3 19250666 2055378 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Positive_regulation TNF MAPK3 19267548 2045603 Since activated p38 *mediates* [TNF-alpha] production , we examined the effect of radiation on LPS induced activation of p38 MAPK and TNF-alpha production . Positive_regulation TNF MAPK3 19287189 2046605 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Positive_regulation TNF MAPK3 19351958 2088780 Specific inhibitors of p38 and glycogen synthase kinase 3 *suppressed* [TNF-alpha] production and maturation of fucoidan treated PBDCs . Positive_regulation TNF MAPK3 19427347 2106783 [TNF-alpha] *induced* the phosphorylation of p38 , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation TNF MAPK3 19477265 2107661 These results show that chronic ethanol feeding enhances Fas induced liver injury by a mechanism associated with induction of CYP2E1 , elevated serum [TNF-alpha] levels , and *activation* of . Positive_regulation TNF MAPK3 19493203 2091427 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Positive_regulation TNF MAPK3 19493203 2091453 In conclusion , our data indicate that signaling is *required* to induce maximal [TNF-alpha] production in macrophages during Orientia infection . Positive_regulation TNF MAPK3 19541467 2142430 [TNF-alpha] *induced* p38 and ( ERK1/2 ) activities that contributed to VCAM-1expression was obviously attenuated after pre treating RAECs with paeonol . Positive_regulation TNF MAPK3 19733186 2147107 Pre-treatment with C-K significantly inhibited zymosan mediated secretion of [tumor necrosis factor-alpha] , interleukin (IL)-6 , and IL-12 p40 , and the *activation* of and p38 . Positive_regulation TNF MAPK3 19751557 2135277 p38MAPK 's phosphorylation is important in pathogenesis of MODS , and phosphorylation of can *enhance* TNF-alpha mRNA transcription and secretion of [TNF-alpha] from peripheral blood mononuclear cells , which is the mechanism of increased TNF-alpha in MODS . Positive_regulation TNF MAPK3 20010392 2175032 Because p38 ( p38 ) *upregulates* [TNF-alpha] expression and may play a crucial role in pain sensation , we investigated the effect of one injection of inhibitor on expression of the pain related neuropeptide calcitonin gene related peptide (CGRP) . Positive_regulation TNF MAPK3 20068037 2235132 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Positive_regulation TNF MAPK3 20083499 2380895 For the first time , we show that , in fish macrophages , [TNF-a] is processed by TACE-like activity and this cleavage is *dependent* upon the activation of ERK , and JNK signaling pathways by LPS . Positive_regulation TNF MAPK3 20237583 2223932 Interestingly , endothelial nitric oxide synthase (eNOS) promotes TNF-alpha expression by enhancing p38 MAPK activation , whereas neuronal NOS (nNOS) *inhibits* [TNF-alpha] production by reducing Ca2+ dependent activity . Positive_regulation TNF MAPK3 20499049 2276361 Expression of [TNF-alpha] and IL-6 in HMC-1 cells treated with bisphenol A is *attenuated* by plant originating glycoprotein ( 75 kDa ) by blocking p38 . Positive_regulation TNF MAPK3 20589681 2334365 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Positive_regulation TNF MAPK3 20646342 2292565 [TNF-alpha] *induced* a significant increase in p38 phosphorylation . Positive_regulation TNF MAPK3 20868379 2337170 [TNF-a] expression was *mediated* in a time dependent manner by p38 , activation of which is under the control of MKP1 . Positive_regulation TNF MAPK3 21208554 2374419 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Positive_regulation TNF MAPK3 21402598 2426929 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Positive_regulation TNF MAPK3 21545687 2554366 [Tumour necrosis factor-a (TNF-a)] significantly *induced* phosphorylation of p38 , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation TNF MAPK3 21642540 2446236 Pretreatment with TAT-SNAP-23 inhibited the increase in plasma membrane expression of gp91(phox) in TNF-a primed neutrophils , whereas [TNF-a] *activation* of ERK1/2 and p38 was not affected . Positive_regulation TNF MAPK3 21849907 2495993 All 3 inhibitors *suppressed* LPS induced [TNF-a] and I-309 expression in human primary monocytes . Positive_regulation TNF MAPK3 21911466 2491944 By focusing on mitogen activated protein kinases , we show that both and p38 , but not JNK , are *required* for hBD- , [TNF-a-] , and IL-1ß induced secretion of CCL20 by HOECs . Positive_regulation TNF MAPK3 22002864 2526303 In this study , we found that inhibition of p38 with SB-203580 ( SB ) *reduced* H ( 2 ) O ( 2 ) -stimulated secretion of [TNF-a] , whereas pre-activation of p38 MAPK with sodium arsenite ( SA ) enhanced H ( 2 ) O ( 2 ) -stimulated secretion of TNF-a . Positive_regulation TNF MAPK3 22301607 2580353 P38 and *regulate* LPS induced [IL-6/TNF-a] expression through an NF-?B dependent manner and an NF-?B independent manner , respectively . Positive_regulation TNF MAPK3 22343222 2617762 Using immunohistological techniques , we showed a higher epithelial expression of [TNF-a] , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation TNF MAPK3 22385244 2566474 The use of selective inhibitors of signalling pathways revealed that induction of TG2 by IFN-? was mediated by phosphoinositide 3-kinase (PI3K) , while c-Jun N-terminal kinase (JNK) and p38 were *required* for [TNF-a] activation . Positive_regulation TNF MAPK3 22744777 2853448 After LPS administration , all animals displayed increased arterial carbon dioxide partial pressure ( PaCO2 ) and decreased arterial oxygen partial pressure ( PaO2 ) , arterial oxygen saturation ( SO2 ) , HCO3 ( - ) concentration and pH , and *increased* LWCI , MPO activity , interleukin (IL)-1ß , IL-6 and [tumor necrosis factor (TNF)-a] mRNA expression , NF-?B p65 positive staining and p38 activation compared with normal controls ( all P < 0.01 ) . Positive_regulation TNF MAPK3 22767513 2696990 We also observed that in THP-1 and PBMCs , AIMP1 induced [TNF-a] secretion , mediated by CD23 , *involved* activation of . Positive_regulation TNF MAPK3 23108309 2691119 AR was necessary for [TNF-a] *activation* of and Akt signaling in hepatocytes . Positive_regulation TNF MAPK3 23188524 2745411 We found that and Akt inhibitors , but not PI3K inhibitor , remarkably *suppressed* ACPA mediated [TNF-a] production . Positive_regulation TNF MAPK3 23354775 2769958 p38a may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , [tumor necrosis factor-a] , interleukin-1ß , and oxidative stress . Positive_regulation TNF MAPK3 23364439 2754525 Conversely , HTS activated p38 mitogen activated protein kinase (MAPK) and enhanced [TNF-a] *activation* of p38 . Positive_regulation TNF MAPK3 23557259 2777806 Inhibition of and CD137 signaling *reduce* dengue virus induced [TNF-a] secretion and apoptosis . Positive_regulation TNF MAPK3 23734186 2796929 Bla g 2 can stimulate up-regulation of inflammatory cytokines including [TNF-alpha] and IL-6 and *activation* of nuclear factor kappa B ( NF-kB/p65 ) , p38 ( p38 ) , ERK , and JNK in cultured fibrocytes . Positive_regulation TNF MAPK3 24089494 2848136 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed [TNF] receptor 1 and *requires* activation of p38 , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation TNF MAPK3 24247374 2879610 Pharmacological inhibitors of p38 and partly *attenuated* IL-17A induced [TNF-a] , IL-1ß , and IL-6 production . Positive_regulation TNF MAPK3 24304472 2904828 To determine whether *regulates* c-Fos expression , p38 phosphorylation , NF-?B activation and [TNF-a] production , cardiomyocytes were also treated with U0126 , a selective ERK1/2 inhibitor . Positive_regulation TNF MAPK3 24441870 2922971 On the other hand , [TNF-a] could *induce* Akt and p42/p44 translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation TNF MAPK3 24750790 2936518 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas [TNFalpha] and NO production *required* all three . Positive_regulation TNF MAPK3 7722327 301746 [TNF-alpha] *induces* tyrosine phosphorylation of in adherent human neutrophils . Positive_regulation TNF MAPK3 7722327 301798 These results indicate that [TNF] signaling *involves* activation of . Positive_regulation TNF MAPK3 9148963 430053 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Positive_regulation TNF MAPK3 9418855 480530 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Positive_regulation TNF MAPK3 9439626 482884 These findings suggest a role for [TNF-alpha] in the regulation of intestinal epithelial cell growth and that the mitogenic effect of TNF-alpha *requires* protein tyrosine phosphorylation and activation . Positive_regulation TNF MAPK3 9551930 499082 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , IL-1beta , and [TNF-alpha] , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation TNF MAPK3 9706151 526176 We hypothesized that hydrogen peroxide ( H2O2 ) induces myocardial dysfunction and cardiomyocyte death via P38 *mediated* myocardial [tumor necrosis factor (TNF)] production . Positive_regulation TNF MAPK3 9730957 530348 However , in contrast to the wild-type endotoxin , it failed to induce significant production of [tumor necrosis factor-alpha] and macrophage inflammatory protein-1alpha by monocytes and did not *induce* the phosphorylation and nuclear translocation of . Positive_regulation TNF MAPK3 9766635 538492 [TNF-alpha] and GM-CSF priming of superoxide release stimulated by N-formyl-methionyl-leucyl-phenylalanine was significantly *attenuated* by the MEK inhibitor , PD098059 , and the p38 inhibitor , SB203580 . Positive_regulation TNF MAPK3 9864164 582564 A selective p38 inhibitor , SB203580 , *blocked* [TNF] -- or ceramide induced CREB phosphorylation , but had no effect on the induction of apoptosis mediated by these agents . Positive_regulation TNF MAPK3 9864164 582645 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Positive_regulation TNF MAPK3 9883899 558197 *Activation* of p42/p44 mitogen activated protein kinases (MAPK) and p38 by [tumor necrosis factor (TNF)] is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation TNF MAPK4 10079106 595512 Specific inhibitors of p38alpha *blocked* LPS induced adhesion , nuclear factor-kappa B (NF-kappaB) activation , and synthesis of [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF MAPK4 10079106 595566 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Positive_regulation TNF MAPK4 10079106 595579 These findings support a pathway by which LPS stimulation of neutrophils results in activation of MKK3 , which in turn activates p38alpha , ultimately regulating adhesion , NF-kappaB activation , *enhanced* gene expression of [TNF-alpha] , and regulation of TNF-alpha synthesis . Positive_regulation TNF MAPK4 10210635 607642 ( 1 ) The human heart produces TNF-alpha after I/R , ( 2 ) p38 *mediates* myocardial I/R induced [TNF-alpha] production , ( 3 ) p38 MAPK inhibition limits functional impairment after I/R , and ( 4 ) inhibition of ischemia induced TNF-alpha production may represent a potent therapeutic strategy for improving myocardial function after angioplasty , coronary bypass , or heart transplantation . Positive_regulation TNF MAPK4 10329111 613030 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Positive_regulation TNF MAPK4 10521481 653041 Engagement of tumor necrosis factor (TNF) receptor 1 leads to ATF-2- and p38 *dependent* [TNF-alpha] gene expression . Positive_regulation TNF MAPK4 10521481 653099 The study presented here shows that autoregulation of [TNF-alpha] gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation TNF MAPK4 10586056 571705 Ligation of microglial CD40 results in p44/42 *dependent* [TNF-alpha] production that is opposed by TGF-beta 1 and IL-10 . Positive_regulation TNF MAPK4 10586056 571759 Inhibition of the upstream activator of p44/42 , mitogen activated protein/extracellular signal related kinase kinase 1/2 , with PD98059 , decreases phosphorylation of p44/42 MAPK and significantly *reduces* [TNF-alpha] release following ligation of microglial CD40 . Positive_regulation TNF MAPK4 10601128 574178 [Tumor necrosis factor-alpha (TNF-alpha)] alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation TNF MAPK4 10620700 657672 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Positive_regulation TNF MAPK4 10653605 663297 These results suggest that ( 1 ) while PTK and are *essential* for the production of [TNFalpha] , they are not necessary for the induction of MnSOD by LPS , and ( 2 ) while activation of NFkappaB alone is insufficient for the induction of TNFalpha mRNA by LPS , it is necessary for the induction of TNFalpha as well as MnSOD mRNAs . Positive_regulation TNF MAPK4 10655266 663529 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Positive_regulation TNF MAPK4 10657669 664192 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Positive_regulation TNF MAPK4 10669634 665797 In this study , we show that [TNF-alpha] *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation TNF MAPK4 10783388 707825 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Positive_regulation TNF MAPK4 10857765 704536 These findings indicate that beta2-adrenoceptor stimulation during an LPS challenge prevented [TNF-alpha] production as a *consequence* of inhibition and enhanced cAMP generation , which at a later stage was associated with an anti-inflammatory effect of IL-6 . Positive_regulation TNF MAPK4 11076936 786255 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Positive_regulation TNF MAPK4 11153597 761142 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as [tumour necrosis factor-alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) , in vitro and in vivo by inhibiting p38 . Positive_regulation TNF MAPK4 11221891 787434 Kinase suppressor of ras is necessary for [tumor necrosis factor] alpha *activation* of extracellular signal regulated in intestinal epithelial cells . Positive_regulation TNF MAPK4 11221891 787460 activity is *essential* for [tumor necrosis factor (TNF)] alpha receptor 1 regulation of intestinal epithelial cell proliferation . Positive_regulation TNF MAPK4 11278471 802562 [Tumor necrosis factor-alpha] induction of endothelial ephrin A1 expression is *mediated* by a p38 and SAPK/JNK dependent but nuclear factor-kappa B-independent mechanism . Positive_regulation TNF MAPK4 11299196 803168 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Positive_regulation TNF MAPK4 11443053 833729 Finally , PD-98059 , a p42/44 pathway inhibitor , *blocked* [TNF-alpha] upregulation by eNOS ( P = 0.02 ) . Positive_regulation TNF MAPK4 11443055 833743 p38 *mediates* renal tubular cell [TNF-alpha] production and TNF-alpha dependent apoptosis during simulated ischemia . Positive_regulation TNF MAPK4 11443055 833783 Furthermore , 60 min of ischemia induced renal tubular cell apoptosis at all substrate replacement time points examined , with peak apoptotic cell death occurring after either 24 or 48 h . p38 MAPK inhibition abolished [TNF-alpha] mRNA production and TNF-alpha bioactivity , and both p38 inhibition and TNF-alpha neutralization ( anti-porcine TNF-alpha antibody ) *prevented* apoptosis after 60 min of SI . Positive_regulation TNF MAPK4 11443055 833796 These results constitute the initial demonstration that 1 ) renal tubular cells produce TNF-alpha mRNA and biologically active [TNF-alpha] and undergo apoptosis in response to SI , and 2 ) p38 *mediates* renal tubular cell TNF-alpha production and TNF-alpha dependent apoptosis after SI . Positive_regulation TNF MAPK4 11675371 873179 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Positive_regulation TNF MAPK4 11699878 878393 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Positive_regulation TNF MAPK4 11715476 581274 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Positive_regulation TNF MAPK4 11728947 884760 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Positive_regulation TNF MAPK4 11815388 907597 ( ERK ) blockade ( PD-98059 ) *attenuated* [TNF-alpha] secretion , an effect synergistically amplified in the presence of SB-203580 . Positive_regulation TNF MAPK4 11994432 938940 Evidence for a dual mechanism for IL-10 suppression of [TNF-alpha] production that does not *involve* inhibition of p38 or NF-kappa B in primary human macrophages . Positive_regulation TNF MAPK4 12130576 966552 Phosphorylation of p38 was *induced* by RANKL , IL-1 , [TNFalpha] , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation TNF MAPK4 12391245 1007386 Release of [TNF-alpha] , macrophage-inflammatory protein (MIP)-2 ( MIP-1beta ) , and IL-8 by LPS stimulated neutrophils was also *reduced* by poststimulation p38 inhibition . Positive_regulation TNF MAPK4 12392277 1007665 Inhibition of p38 with SB203580 *inhibited* the production of [TNF-alpha] and IL-10 by LPS stimulated KCs , whereas blockade of ERK1/2 with PD98059 could reduce TNF-alpha production , but did not affect IL-10 production . Positive_regulation TNF MAPK4 12393915 1025404 This model probiotic also inhibits *activation* of the pro-apoptotic by [tumor necrosis factor] , interleukin-1alpha , or gamma-interferon . Positive_regulation TNF MAPK4 12438325 1016567 The activation of protein tyrosine kinases (PTK) and the serine/threonine kinases p38 and ERK was apparently *required* for MTSA-10 induction of [TNF-alpha] and NO release , as revealed by specific kinase inhibitors . Positive_regulation TNF MAPK4 12506117 1056931 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Positive_regulation TNF MAPK4 12631113 1067654 The present data indicate that [TNF-alpha] *activation* of PKCzeta/iota , p42/44 , c-Jun/AP-1 , and p65/NF-kappaB are involved in TNF-alpha stimulated MC fractalkine expression , with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro . Positive_regulation TNF MAPK4 12637577 1099257 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and [tumor necrosis factor alpha (TNFalpha)] *requires* p38 activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation TNF MAPK4 12694807 1080900 [TNF-alpha] *induced* the phosphorylation of p44/p42 and p38 MAP kinase . Positive_regulation TNF MAPK4 12881424 1116121 Importantly , [TNF] does not *induce* ROS accumulation or prolonged activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death Positive_regulation TNF MAPK4 12969251 1139154 Inhibition of the MAP-kinase-kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) pathway , but not that of ( MAPK-p38 ) , *reduced* NO , [TNF-alpha] and IL-6 significantly , suggesting that simultaneous activation of the first two pathways is necessary for the AGE induced induction of these pro-inflammatory stimuli . Positive_regulation TNF MAPK4 14654378 1176817 These findings suggest that the pre-ischemic *activation* of by [TNF] does not contribute to cardioprotection afforded by this agent . Positive_regulation TNF MAPK4 14980980 1220296 The selective p38 inhibitor , SB203580 , *inhibited* the promoter activities of iNOS and COX-2 rather than that of [TNF-alpha] . Positive_regulation TNF MAPK4 15027449 1222854 Apoptosis caused by chronic ethanol treatment may be due to ethanol potentiation of [TNF] *induced* activation of p38 . Positive_regulation TNF MAPK4 15100302 1239722 Previous studies have shown the mitogen activated protein kinases ( MAPKs ) to be activated in macrophages upon infection with Mycobacterium , and that expression of [TNF-alpha] and inducible NO synthase by infected macrophages was *dependent* on activation . Positive_regulation TNF MAPK4 15139014 1246947 The increase in [TNF-alpha] release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation TNF MAPK4 15233873 1269380 A. semen also inhibited the expression of [TNF-alpha] and the *activation* of , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation TNF MAPK4 15248214 1271211 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of [TNFalpha] and IL-1beta by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation TNF MAPK4 15302094 1283840 Selective p42/44 inhibitor could *reduce* the Pb- and LPS triggered [TNF-alpha] expression in U-373MG cells . Positive_regulation TNF MAPK4 15557189 1340413 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Positive_regulation TNF MAPK4 15557189 1340439 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Positive_regulation TNF MAPK4 15592496 1375218 Tenascin-W is found in malignant mammary tumors , promotes alpha8 integrin dependent motility and *requires* activity for BMP-2 and [TNF-alpha] induced expression in vitro . Positive_regulation TNF MAPK4 15614136 1357465 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Positive_regulation TNF MAPK4 15701814 1416530 p38 activation *leads* to increased production of [TNF-alpha] in ischemic injury and in macrophages . Positive_regulation TNF MAPK4 15701814 1416557 Inhibition of p38 activation *led* to inhibition of [TNF-alpha] production . Positive_regulation TNF MAPK4 15703956 1497457 *Activation* of p38 and phosphatidylinositol 3-kinase (PI3K) by [TNF-alpha] was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation TNF MAPK4 15833800 1425441 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Positive_regulation TNF MAPK4 15867183 1404204 In cultured cardiac myocytes , specific activation of stress activated , p38 , by upstream activator MKK6bE *led* to significant induction of [tumor necrosis factor-alpha] and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation TNF MAPK4 15893422 1419734 We also investigated whether specific inhibition of p38 and Erk1/2 would *inhibit* [TNF-alpha] and IL-6 production and thus astrocyte apoptosis , and proliferation , respectively . Positive_regulation TNF MAPK4 15925386 1440375 Our observations show that calcium , activation , HIF-1alpha , and NF-kappaB are *necessary* for ethanol induced [TNF-alpha] and TGF-beta1 expression . Positive_regulation TNF MAPK4 16051807 1438613 Specific inhibitors of p38 significantly *reduced* the H5N1/97 induced [TNF-alpha] expression in macrophages . Positive_regulation TNF MAPK4 16081599 1460339 These results indicate that gp120 elicited [TNF-alpha] production by macrophages *involves* chemokine receptor mediated PI-3K and activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and ERK-1/2 independently regulate TNF-alpha production . Positive_regulation TNF MAPK4 16271232 1479207 Similarly , the increased gene expression of proinflammatory cytokines [TNF-alpha] and IL-1beta in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation TNF MAPK4 16275991 1480272 Angiotensin II , [tumor necrosis factor-alpha] , or epidermal growth factor *induced* phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation TNF MAPK4 16291729 1526057 *Activation* of and Akt by anti-HER2/neu [ScFv-TNF-alpha] inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation TNF MAPK4 16403817 1540130 The [TNF] + dex stimulated increase in leptin was associated with an increase in p38 MAPK activity and was totally *blocked* by p38 inhibitors . Positive_regulation TNF MAPK4 16438946 1495431 Although gAd partially increased cAMP concentration and PKA activity , it directly reduced leptin induced ERK1/2 and p38 phosphorylation thus *inhibiting* [TNF-alpha] production . Positive_regulation TNF MAPK4 16480618 1496069 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Positive_regulation TNF MAPK4 16480618 1496108 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Positive_regulation TNF MAPK4 16517732 1530907 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of [TNF] , but not IL-6 , *requires* the activity of p38 . Positive_regulation TNF MAPK4 16573652 1556126 HA-mediated [TNF-alpha] production *required* p38 , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation TNF MAPK4 16581537 1543740 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Positive_regulation TNF MAPK4 16596287 1544886 These results collectively reveal that AV-ext *inhibits* [TNF-alpha] release from macrophages by suppressing and NF-kappaB signaling pathways and suggest that AV-ext may be beneficial for the treatment of endotoxin shock or sepsis . Positive_regulation TNF MAPK4 16771851 1572709 this process then leads to modulation of p38 *dependent* IL-8 and [TNF-alpha] release from the epithelium . Positive_regulation TNF MAPK4 16781693 1585605 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and [TNF-alpha] and the *activation* of 's are potentially positive signals for IL-10 production . Positive_regulation TNF MAPK4 16867160 1592838 Further , the activation of p38 and extracellular signal regulated kinase was *required* for the induction of [TNF-alpha] and IL-6 by MTB12 , as well as by the 30-kDa Ag . Positive_regulation TNF MAPK4 17032936 1692726 The stimulation of [TNF-alpha] production was *dependent* on cisplatin induced activation of p38 and was associated with phosphorylation of the translation initiation factor eIF4E and its upstream kinase Mnk1 . Positive_regulation TNF MAPK4 17032936 1692739 Inhibition of p38 and , to a lesser extent , ERK , *reduced* cisplatin+endotoxin stimulated [TNF-alpha] production and phosphorylation of Mnk1 and eIF4E . Positive_regulation TNF MAPK4 17074860 1675547 B. burgdorferi induced [TNF-alpha] production is also *dependent* on the activation of p38 . Positive_regulation TNF MAPK4 17117477 1677359 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Positive_regulation TNF MAPK4 17126905 1686519 Differential regulation of [TNFalpha] and GM-CSF *induced* activation of P38 in neutrophils and eosinophils . Positive_regulation TNF MAPK4 17131360 1700733 In addition , we recently found that p38 *mediates* [TNF-alpha] upregulation of atrogin-1/MAFbx expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation TNF MAPK4 17138860 1653562 The purpose of this study was to determine whether the , ERK1/2 , and p38 MAPK are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Positive_regulation TNF MAPK4 17172975 1679376 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK4 17172975 1679402 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK4 17202326 1680804 Augmented lipopolysaccharide induced [TNF-alpha] production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK4 17202326 1680830 In this study , we show that augmented LPS induced [TNF-alpha] production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK4 17395780 1766151 Here we demonstrate that Rab7b can negatively regulate lipopolysaccharide (LPS) induced production of [tumor necrosis factor (TNF)-alpha] , IL-6 , nitric oxide , and IFN-beta , and potentiate LPS induced *activation* of , nuclear factor kappaB , and IFN regulatory factor 3 signaling pathways in macrophages by promoting the degradation of TLR4 . Positive_regulation TNF MAPK4 17438131 1742745 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by [TNF-alpha] and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation TNF MAPK4 17553937 1791997 Twenty-four hours thereafter , splenic macrophages were isolated , and their IL-6 and [TNF-alpha] production and *activation* of and NF-kappaB were measured . Positive_regulation TNF MAPK4 17607712 1798177 Although [TNF] *induced* the activation of p38 , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation TNF MAPK4 17902045 1835078 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Positive_regulation TNF MAPK4 17934341 1813485 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Positive_regulation TNF MAPK4 17940160 1888985 Conversely , Ser phosphorylation of IRS-2 mediated by [TNF-alpha] *activation* of was the mechanism found in brown adipocytes . Positive_regulation TNF MAPK4 17964662 1831051 Taken together , these results suggest that linomide *inhibits* [TNF-alpha] production by suppressing the activation of NF-kappaB and , which might , at least in part , contribute to the beneficial effects of linomide in the treatment of autoimmune diseases . Positive_regulation TNF MAPK4 17994109 1851146 [TNF-alpha] triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation TNF MAPK4 18227157 1884335 It was shown that these three proteins could ( i ) induce expression of [tumor necrosis factor alpha (TNF-alpha)] and tissue factor and ( ii ) *induce* phosphorylation of p44/42 and activation of early growth response factor 1 (Egr-1) . Positive_regulation TNF MAPK4 18296636 1878862 Whereas the induction of [TNFalpha] , IL-1beta , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation TNF MAPK4 18303184 1873525 Inhibition of p38 activation selectively *blocked* DNCB induced [TNF-alpha] release , but not NiSO ( 4 ) -induced release . Positive_regulation TNF MAPK4 18314537 1919435 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Positive_regulation TNF MAPK4 18390808 1925668 We tested the hypothesis that p38 activation is *necessary* for [TNF-alpha] production , neutrophil activation , and subsequent liver injury . Positive_regulation TNF MAPK4 18622138 1984360 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Positive_regulation TNF MAPK4 18675993 2011331 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Positive_regulation TNF MAPK4 19002259 1991233 Peptidoglycan stimulated monocyte p38 and p38 activity was *required* for [TNFalpha] production by the cells . Positive_regulation TNF MAPK4 19040616 2017409 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Positive_regulation TNF MAPK4 19043204 1998822 Moreover , [TNF-alpha] production was *prevented* by NF-kappaB and inhibitors . Positive_regulation TNF MAPK4 19052649 1999788 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Positive_regulation TNF MAPK4 19250666 2055379 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Positive_regulation TNF MAPK4 19267548 2045604 Since activated p38 *mediates* [TNF-alpha] production , we examined the effect of radiation on LPS induced activation of p38 MAPK and TNF-alpha production . Positive_regulation TNF MAPK4 19287189 2046606 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Positive_regulation TNF MAPK4 19351958 2088781 Specific inhibitors of p38 and glycogen synthase kinase 3 *suppressed* [TNF-alpha] production and maturation of fucoidan treated PBDCs . Positive_regulation TNF MAPK4 19427347 2106784 [TNF-alpha] *induced* the phosphorylation of p38 , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation TNF MAPK4 19477265 2107662 These results show that chronic ethanol feeding enhances Fas induced liver injury by a mechanism associated with induction of CYP2E1 , elevated serum [TNF-alpha] levels , and *activation* of . Positive_regulation TNF MAPK4 19493203 2091428 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Positive_regulation TNF MAPK4 19493203 2091454 In conclusion , our data indicate that signaling is *required* to induce maximal [TNF-alpha] production in macrophages during Orientia infection . Positive_regulation TNF MAPK4 19751557 2135278 p38MAPK 's phosphorylation is important in pathogenesis of MODS , and phosphorylation of can *enhance* TNF-alpha mRNA transcription and secretion of [TNF-alpha] from peripheral blood mononuclear cells , which is the mechanism of increased TNF-alpha in MODS . Positive_regulation TNF MAPK4 20010392 2175033 Because p38 ( p38 ) *upregulates* [TNF-alpha] expression and may play a crucial role in pain sensation , we investigated the effect of one injection of inhibitor on expression of the pain related neuropeptide calcitonin gene related peptide (CGRP) . Positive_regulation TNF MAPK4 20068037 2235133 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Positive_regulation TNF MAPK4 20083499 2380896 For the first time , we show that , in fish macrophages , [TNF-a] is processed by TACE-like activity and this cleavage is *dependent* upon the activation of ERK , and JNK signaling pathways by LPS . Positive_regulation TNF MAPK4 20499049 2276362 Expression of [TNF-alpha] and IL-6 in HMC-1 cells treated with bisphenol A is *attenuated* by plant originating glycoprotein ( 75 kDa ) by blocking p38 . Positive_regulation TNF MAPK4 20589681 2334366 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Positive_regulation TNF MAPK4 20646342 2292566 [TNF-alpha] *induced* a significant increase in p38 phosphorylation . Positive_regulation TNF MAPK4 20868379 2337171 [TNF-a] expression was *mediated* in a time dependent manner by p38 , activation of which is under the control of MKP1 . Positive_regulation TNF MAPK4 21208554 2374420 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Positive_regulation TNF MAPK4 21402598 2426930 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Positive_regulation TNF MAPK4 21545687 2554367 [Tumour necrosis factor-a (TNF-a)] significantly *induced* phosphorylation of p38 , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation TNF MAPK4 21642540 2446237 Pretreatment with TAT-SNAP-23 inhibited the increase in plasma membrane expression of gp91(phox) in TNF-a primed neutrophils , whereas [TNF-a] *activation* of ERK1/2 and p38 was not affected . Positive_regulation TNF MAPK4 21849907 2495994 All 3 inhibitors *suppressed* LPS induced [TNF-a] and I-309 expression in human primary monocytes . Positive_regulation TNF MAPK4 22002864 2526304 In this study , we found that inhibition of p38 with SB-203580 ( SB ) *reduced* H ( 2 ) O ( 2 ) -stimulated secretion of TNF-a , whereas pre-activation of p38 MAPK with sodium arsenite ( SA ) enhanced H ( 2 ) O ( 2 ) -stimulated secretion of [TNF-a] . Positive_regulation TNF MAPK4 22343222 2617763 Using immunohistological techniques , we showed a higher epithelial expression of [TNF-a] , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation TNF MAPK4 22385244 2566475 The use of selective inhibitors of signalling pathways revealed that induction of TG2 by IFN-? was mediated by phosphoinositide 3-kinase (PI3K) , while c-Jun N-terminal kinase (JNK) and p38 were *required* for [TNF-a] activation . Positive_regulation TNF MAPK4 22744777 2853449 After LPS administration , all animals displayed increased arterial carbon dioxide partial pressure ( PaCO2 ) and decreased arterial oxygen partial pressure ( PaO2 ) , arterial oxygen saturation ( SO2 ) , HCO3 ( - ) concentration and pH , and *increased* LWCI , MPO activity , interleukin (IL)-1ß , IL-6 and [tumor necrosis factor (TNF)-a] mRNA expression , NF-?B p65 positive staining and p38 activation compared with normal controls ( all P < 0.01 ) . Positive_regulation TNF MAPK4 23188524 2745412 We found that and Akt inhibitors , but not PI3K inhibitor , remarkably *suppressed* ACPA mediated [TNF-a] production . Positive_regulation TNF MAPK4 23354775 2769959 p38a may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , [tumor necrosis factor-a] , interleukin-1ß , and oxidative stress . Positive_regulation TNF MAPK4 23364439 2754526 Conversely , HTS activated p38 mitogen activated protein kinase (MAPK) and enhanced [TNF-a] *activation* of p38 . Positive_regulation TNF MAPK4 23557259 2777807 Inhibition of and CD137 signaling *reduce* dengue virus induced [TNF-a] secretion and apoptosis . Positive_regulation TNF MAPK4 23734186 2796930 Bla g 2 can stimulate up-regulation of inflammatory cytokines including [TNF-alpha] and IL-6 and *activation* of nuclear factor kappa B ( NF-kB/p65 ) , p38 ( p38 ) , ERK , and JNK in cultured fibrocytes . Positive_regulation TNF MAPK4 24089494 2848137 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed [TNF] receptor 1 and *requires* activation of p38 , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation TNF MAPK4 24441870 2922972 On the other hand , [TNF-a] could *induce* Akt and p42/p44 translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation TNF MAPK4 24750790 2936519 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas [TNFalpha] and NO production *required* all three . Positive_regulation TNF MAPK4 7722327 301747 [TNF-alpha] *induces* tyrosine phosphorylation of in adherent human neutrophils . Positive_regulation TNF MAPK4 7722327 301799 These results indicate that [TNF] signaling *involves* activation of . Positive_regulation TNF MAPK4 9148963 430054 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Positive_regulation TNF MAPK4 9418855 480531 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Positive_regulation TNF MAPK4 9439626 482885 These findings suggest a role for [TNF-alpha] in the regulation of intestinal epithelial cell growth and that the mitogenic effect of TNF-alpha *requires* protein tyrosine phosphorylation and activation . Positive_regulation TNF MAPK4 9551930 499083 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , IL-1beta , and [TNF-alpha] , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation TNF MAPK4 9706151 526177 We hypothesized that hydrogen peroxide ( H2O2 ) induces myocardial dysfunction and cardiomyocyte death via P38 *mediated* myocardial [tumor necrosis factor (TNF)] production . Positive_regulation TNF MAPK4 9730957 530349 However , in contrast to the wild-type endotoxin , it failed to induce significant production of [tumor necrosis factor-alpha] and macrophage inflammatory protein-1alpha by monocytes and did not *induce* the phosphorylation and nuclear translocation of . Positive_regulation TNF MAPK4 9766635 538493 [TNF-alpha] and GM-CSF priming of superoxide release stimulated by N-formyl-methionyl-leucyl-phenylalanine was significantly *attenuated* by the MEK inhibitor , PD098059 , and the p38 inhibitor , SB203580 . Positive_regulation TNF MAPK4 9864164 582565 A selective p38 inhibitor , SB203580 , *blocked* [TNF] -- or ceramide induced CREB phosphorylation , but had no effect on the induction of apoptosis mediated by these agents . Positive_regulation TNF MAPK4 9864164 582646 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Positive_regulation TNF MAPK4 9883899 558198 *Activation* of p42/p44 and p38 MAPK by [tumor necrosis factor (TNF)] is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation TNF MAPK6 10079106 595513 Specific inhibitors of p38alpha *blocked* LPS induced adhesion , nuclear factor-kappa B (NF-kappaB) activation , and synthesis of [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF MAPK6 10079106 595567 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Positive_regulation TNF MAPK6 10079106 595580 These findings support a pathway by which LPS stimulation of neutrophils results in activation of MKK3 , which in turn activates p38alpha , ultimately regulating adhesion , NF-kappaB activation , *enhanced* gene expression of [TNF-alpha] , and regulation of TNF-alpha synthesis . Positive_regulation TNF MAPK6 10210635 607643 ( 1 ) The human heart produces TNF-alpha after I/R , ( 2 ) p38 *mediates* myocardial I/R induced [TNF-alpha] production , ( 3 ) p38 MAPK inhibition limits functional impairment after I/R , and ( 4 ) inhibition of ischemia induced TNF-alpha production may represent a potent therapeutic strategy for improving myocardial function after angioplasty , coronary bypass , or heart transplantation . Positive_regulation TNF MAPK6 10329111 613031 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Positive_regulation TNF MAPK6 10521481 653042 Engagement of tumor necrosis factor (TNF) receptor 1 leads to ATF-2- and p38 *dependent* [TNF-alpha] gene expression . Positive_regulation TNF MAPK6 10521481 653100 The study presented here shows that autoregulation of [TNF-alpha] gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation TNF MAPK6 10586056 571706 Ligation of microglial CD40 results in p44/42 *dependent* [TNF-alpha] production that is opposed by TGF-beta 1 and IL-10 . Positive_regulation TNF MAPK6 10586056 571760 Inhibition of the upstream activator of p44/42 , mitogen activated protein/extracellular signal related kinase kinase 1/2 , with PD98059 , decreases phosphorylation of p44/42 MAPK and significantly *reduces* [TNF-alpha] release following ligation of microglial CD40 . Positive_regulation TNF MAPK6 10601128 574179 [Tumor necrosis factor-alpha (TNF-alpha)] alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation TNF MAPK6 10620700 657673 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Positive_regulation TNF MAPK6 10653605 663298 These results suggest that ( 1 ) while PTK and are *essential* for the production of [TNFalpha] , they are not necessary for the induction of MnSOD by LPS , and ( 2 ) while activation of NFkappaB alone is insufficient for the induction of TNFalpha mRNA by LPS , it is necessary for the induction of TNFalpha as well as MnSOD mRNAs . Positive_regulation TNF MAPK6 10655266 663530 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Positive_regulation TNF MAPK6 10657669 664193 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Positive_regulation TNF MAPK6 10669634 665798 In this study , we show that [TNF-alpha] *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation TNF MAPK6 10783388 707826 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Positive_regulation TNF MAPK6 10857765 704537 These findings indicate that beta2-adrenoceptor stimulation during an LPS challenge prevented [TNF-alpha] production as a *consequence* of inhibition and enhanced cAMP generation , which at a later stage was associated with an anti-inflammatory effect of IL-6 . Positive_regulation TNF MAPK6 11076936 786256 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Positive_regulation TNF MAPK6 11153597 761143 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as [tumour necrosis factor-alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) , in vitro and in vivo by inhibiting p38 . Positive_regulation TNF MAPK6 11221891 787435 Kinase suppressor of ras is necessary for [tumor necrosis factor] alpha *activation* of extracellular signal regulated in intestinal epithelial cells . Positive_regulation TNF MAPK6 11221891 787461 activity is *essential* for [tumor necrosis factor (TNF)] alpha receptor 1 regulation of intestinal epithelial cell proliferation . Positive_regulation TNF MAPK6 11278471 802563 [Tumor necrosis factor-alpha] induction of endothelial ephrin A1 expression is *mediated* by a p38 and SAPK/JNK dependent but nuclear factor-kappa B-independent mechanism . Positive_regulation TNF MAPK6 11299196 803169 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Positive_regulation TNF MAPK6 11443053 833730 Finally , PD-98059 , a p42/44 pathway inhibitor , *blocked* [TNF-alpha] upregulation by eNOS ( P = 0.02 ) . Positive_regulation TNF MAPK6 11443055 833744 p38 *mediates* renal tubular cell [TNF-alpha] production and TNF-alpha dependent apoptosis during simulated ischemia . Positive_regulation TNF MAPK6 11443055 833784 Furthermore , 60 min of ischemia induced renal tubular cell apoptosis at all substrate replacement time points examined , with peak apoptotic cell death occurring after either 24 or 48 h . p38 MAPK inhibition abolished [TNF-alpha] mRNA production and TNF-alpha bioactivity , and both p38 inhibition and TNF-alpha neutralization ( anti-porcine TNF-alpha antibody ) *prevented* apoptosis after 60 min of SI . Positive_regulation TNF MAPK6 11443055 833797 These results constitute the initial demonstration that 1 ) renal tubular cells produce TNF-alpha mRNA and biologically active [TNF-alpha] and undergo apoptosis in response to SI , and 2 ) p38 *mediates* renal tubular cell TNF-alpha production and TNF-alpha dependent apoptosis after SI . Positive_regulation TNF MAPK6 11675371 873180 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Positive_regulation TNF MAPK6 11699878 878394 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Positive_regulation TNF MAPK6 11715476 581275 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Positive_regulation TNF MAPK6 11728947 884761 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Positive_regulation TNF MAPK6 11815388 907598 ( ERK ) blockade ( PD-98059 ) *attenuated* [TNF-alpha] secretion , an effect synergistically amplified in the presence of SB-203580 . Positive_regulation TNF MAPK6 11994432 938941 Evidence for a dual mechanism for IL-10 suppression of [TNF-alpha] production that does not *involve* inhibition of p38 or NF-kappa B in primary human macrophages . Positive_regulation TNF MAPK6 12130576 966553 Phosphorylation of p38 was *induced* by RANKL , IL-1 , [TNFalpha] , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation TNF MAPK6 12391245 1007387 Release of [TNF-alpha] , macrophage-inflammatory protein (MIP)-2 ( MIP-1beta ) , and IL-8 by LPS stimulated neutrophils was also *reduced* by poststimulation p38 inhibition . Positive_regulation TNF MAPK6 12392277 1007666 Inhibition of p38 with SB203580 *inhibited* the production of [TNF-alpha] and IL-10 by LPS stimulated KCs , whereas blockade of ERK1/2 with PD98059 could reduce TNF-alpha production , but did not affect IL-10 production . Positive_regulation TNF MAPK6 12393915 1025405 This model probiotic also inhibits *activation* of the pro-apoptotic by [tumor necrosis factor] , interleukin-1alpha , or gamma-interferon . Positive_regulation TNF MAPK6 12438325 1016568 The activation of protein tyrosine kinases (PTK) and the serine/threonine kinases p38 and ERK was apparently *required* for MTSA-10 induction of [TNF-alpha] and NO release , as revealed by specific kinase inhibitors . Positive_regulation TNF MAPK6 12506117 1056932 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Positive_regulation TNF MAPK6 12631113 1067655 The present data indicate that [TNF-alpha] *activation* of PKCzeta/iota , p42/44 , c-Jun/AP-1 , and p65/NF-kappaB are involved in TNF-alpha stimulated MC fractalkine expression , with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro . Positive_regulation TNF MAPK6 12637577 1099258 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and [tumor necrosis factor alpha (TNFalpha)] *requires* p38 activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation TNF MAPK6 12694807 1080901 [TNF-alpha] *induced* the phosphorylation of p44/p42 and p38 MAP kinase . Positive_regulation TNF MAPK6 12881424 1116122 Importantly , [TNF] does not *induce* ROS accumulation or prolonged activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death Positive_regulation TNF MAPK6 12969251 1139155 Inhibition of the MAP-kinase-kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) pathway , but not that of ( MAPK-p38 ) , *reduced* NO , [TNF-alpha] and IL-6 significantly , suggesting that simultaneous activation of the first two pathways is necessary for the AGE induced induction of these pro-inflammatory stimuli . Positive_regulation TNF MAPK6 14654378 1176818 These findings suggest that the pre-ischemic *activation* of by [TNF] does not contribute to cardioprotection afforded by this agent . Positive_regulation TNF MAPK6 14980980 1220297 The selective p38 inhibitor , SB203580 , *inhibited* the promoter activities of iNOS and COX-2 rather than that of [TNF-alpha] . Positive_regulation TNF MAPK6 15027449 1222855 Apoptosis caused by chronic ethanol treatment may be due to ethanol potentiation of [TNF] *induced* activation of p38 . Positive_regulation TNF MAPK6 15100302 1239723 Previous studies have shown the mitogen activated protein kinases ( MAPKs ) to be activated in macrophages upon infection with Mycobacterium , and that expression of [TNF-alpha] and inducible NO synthase by infected macrophages was *dependent* on activation . Positive_regulation TNF MAPK6 15139014 1246948 The increase in [TNF-alpha] release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation TNF MAPK6 15233873 1269381 A. semen also inhibited the expression of [TNF-alpha] and the *activation* of , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation TNF MAPK6 15248214 1271212 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of [TNFalpha] and IL-1beta by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation TNF MAPK6 15302094 1283841 Selective p42/44 inhibitor could *reduce* the Pb- and LPS triggered [TNF-alpha] expression in U-373MG cells . Positive_regulation TNF MAPK6 15557189 1340414 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Positive_regulation TNF MAPK6 15557189 1340440 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Positive_regulation TNF MAPK6 15592496 1375219 Tenascin-W is found in malignant mammary tumors , promotes alpha8 integrin dependent motility and *requires* activity for BMP-2 and [TNF-alpha] induced expression in vitro . Positive_regulation TNF MAPK6 15614136 1357466 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Positive_regulation TNF MAPK6 15701814 1416531 p38 activation *leads* to increased production of [TNF-alpha] in ischemic injury and in macrophages . Positive_regulation TNF MAPK6 15701814 1416558 Inhibition of p38 activation *led* to inhibition of [TNF-alpha] production . Positive_regulation TNF MAPK6 15703956 1497458 *Activation* of p38 and phosphatidylinositol 3-kinase (PI3K) by [TNF-alpha] was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation TNF MAPK6 15833800 1425442 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Positive_regulation TNF MAPK6 15867183 1404205 In cultured cardiac myocytes , specific activation of stress activated , p38 , by upstream activator MKK6bE *led* to significant induction of [tumor necrosis factor-alpha] and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation TNF MAPK6 15893422 1419735 We also investigated whether specific inhibition of p38 and Erk1/2 would *inhibit* [TNF-alpha] and IL-6 production and thus astrocyte apoptosis , and proliferation , respectively . Positive_regulation TNF MAPK6 15925386 1440376 Our observations show that calcium , activation , HIF-1alpha , and NF-kappaB are *necessary* for ethanol induced [TNF-alpha] and TGF-beta1 expression . Positive_regulation TNF MAPK6 16051807 1438614 Specific inhibitors of p38 significantly *reduced* the H5N1/97 induced [TNF-alpha] expression in macrophages . Positive_regulation TNF MAPK6 16081599 1460340 These results indicate that gp120 elicited [TNF-alpha] production by macrophages *involves* chemokine receptor mediated PI-3K and activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and ERK-1/2 independently regulate TNF-alpha production . Positive_regulation TNF MAPK6 16271232 1479208 Similarly , the increased gene expression of proinflammatory cytokines [TNF-alpha] and IL-1beta in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation TNF MAPK6 16275991 1480273 Angiotensin II , [tumor necrosis factor-alpha] , or epidermal growth factor *induced* phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation TNF MAPK6 16291729 1526058 *Activation* of and Akt by anti-HER2/neu [ScFv-TNF-alpha] inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation TNF MAPK6 16403817 1540131 The [TNF] + dex stimulated increase in leptin was associated with an increase in p38 MAPK activity and was totally *blocked* by p38 inhibitors . Positive_regulation TNF MAPK6 16438946 1495432 Although gAd partially increased cAMP concentration and PKA activity , it directly reduced leptin induced ERK1/2 and p38 phosphorylation thus *inhibiting* [TNF-alpha] production . Positive_regulation TNF MAPK6 16480618 1496070 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Positive_regulation TNF MAPK6 16480618 1496109 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Positive_regulation TNF MAPK6 16517732 1530908 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of [TNF] , but not IL-6 , *requires* the activity of p38 . Positive_regulation TNF MAPK6 16573652 1556127 HA-mediated [TNF-alpha] production *required* p38 , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation TNF MAPK6 16581537 1543741 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Positive_regulation TNF MAPK6 16596287 1544887 These results collectively reveal that AV-ext *inhibits* [TNF-alpha] release from macrophages by suppressing and NF-kappaB signaling pathways and suggest that AV-ext may be beneficial for the treatment of endotoxin shock or sepsis . Positive_regulation TNF MAPK6 16771851 1572710 this process then leads to modulation of p38 *dependent* IL-8 and [TNF-alpha] release from the epithelium . Positive_regulation TNF MAPK6 16781693 1585606 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and [TNF-alpha] and the *activation* of 's are potentially positive signals for IL-10 production . Positive_regulation TNF MAPK6 16867160 1592839 Further , the activation of p38 and extracellular signal regulated kinase was *required* for the induction of [TNF-alpha] and IL-6 by MTB12 , as well as by the 30-kDa Ag . Positive_regulation TNF MAPK6 17032936 1692727 The stimulation of [TNF-alpha] production was *dependent* on cisplatin induced activation of p38 and was associated with phosphorylation of the translation initiation factor eIF4E and its upstream kinase Mnk1 . Positive_regulation TNF MAPK6 17032936 1692740 Inhibition of p38 and , to a lesser extent , ERK , *reduced* cisplatin+endotoxin stimulated [TNF-alpha] production and phosphorylation of Mnk1 and eIF4E . Positive_regulation TNF MAPK6 17074860 1675548 B. burgdorferi induced [TNF-alpha] production is also *dependent* on the activation of p38 . Positive_regulation TNF MAPK6 17117477 1677360 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Positive_regulation TNF MAPK6 17126905 1686520 Differential regulation of [TNFalpha] and GM-CSF *induced* activation of P38 in neutrophils and eosinophils . Positive_regulation TNF MAPK6 17131360 1700734 In addition , we recently found that p38 *mediates* [TNF-alpha] upregulation of atrogin-1/MAFbx expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation TNF MAPK6 17138860 1653563 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Positive_regulation TNF MAPK6 17172975 1679377 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK6 17172975 1679403 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK6 17202326 1680805 Augmented lipopolysaccharide induced [TNF-alpha] production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK6 17202326 1680831 In this study , we show that augmented LPS induced [TNF-alpha] production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK6 17395780 1766152 Here we demonstrate that Rab7b can negatively regulate lipopolysaccharide (LPS) induced production of [tumor necrosis factor (TNF)-alpha] , IL-6 , nitric oxide , and IFN-beta , and potentiate LPS induced *activation* of , nuclear factor kappaB , and IFN regulatory factor 3 signaling pathways in macrophages by promoting the degradation of TLR4 . Positive_regulation TNF MAPK6 17438131 1742746 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by [TNF-alpha] and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation TNF MAPK6 17553937 1791998 Twenty-four hours thereafter , splenic macrophages were isolated , and their IL-6 and [TNF-alpha] production and *activation* of and NF-kappaB were measured . Positive_regulation TNF MAPK6 17607712 1798178 Although [TNF] *induced* the activation of p38 , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation TNF MAPK6 17902045 1835079 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Positive_regulation TNF MAPK6 17934341 1813486 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Positive_regulation TNF MAPK6 17940160 1888986 Conversely , Ser phosphorylation of IRS-2 mediated by [TNF-alpha] *activation* of was the mechanism found in brown adipocytes . Positive_regulation TNF MAPK6 17964662 1831052 Taken together , these results suggest that linomide *inhibits* [TNF-alpha] production by suppressing the activation of NF-kappaB and , which might , at least in part , contribute to the beneficial effects of linomide in the treatment of autoimmune diseases . Positive_regulation TNF MAPK6 17994109 1851147 [TNF-alpha] triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation TNF MAPK6 18227157 1884336 It was shown that these three proteins could ( i ) induce expression of [tumor necrosis factor alpha (TNF-alpha)] and tissue factor and ( ii ) *induce* phosphorylation of p44/42 and activation of early growth response factor 1 (Egr-1) . Positive_regulation TNF MAPK6 18296636 1878863 Whereas the induction of [TNFalpha] , IL-1beta , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation TNF MAPK6 18303184 1873526 Inhibition of p38 activation selectively *blocked* DNCB induced [TNF-alpha] release , but not NiSO ( 4 ) -induced release . Positive_regulation TNF MAPK6 18314537 1919436 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Positive_regulation TNF MAPK6 18390808 1925669 We tested the hypothesis that p38 activation is *necessary* for [TNF-alpha] production , neutrophil activation , and subsequent liver injury . Positive_regulation TNF MAPK6 18622138 1984361 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Positive_regulation TNF MAPK6 18675993 2011332 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Positive_regulation TNF MAPK6 19002259 1991234 Peptidoglycan stimulated monocyte p38 and p38 activity was *required* for [TNFalpha] production by the cells . Positive_regulation TNF MAPK6 19040616 2017410 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Positive_regulation TNF MAPK6 19043204 1998823 Moreover , [TNF-alpha] production was *prevented* by NF-kappaB and inhibitors . Positive_regulation TNF MAPK6 19052649 1999789 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Positive_regulation TNF MAPK6 19250666 2055380 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Positive_regulation TNF MAPK6 19267548 2045605 Since activated p38 *mediates* [TNF-alpha] production , we examined the effect of radiation on LPS induced activation of p38 MAPK and TNF-alpha production . Positive_regulation TNF MAPK6 19287189 2046607 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Positive_regulation TNF MAPK6 19351958 2088782 Specific inhibitors of p38 and glycogen synthase kinase 3 *suppressed* [TNF-alpha] production and maturation of fucoidan treated PBDCs . Positive_regulation TNF MAPK6 19427347 2106785 [TNF-alpha] *induced* the phosphorylation of p38 , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation TNF MAPK6 19477265 2107663 These results show that chronic ethanol feeding enhances Fas induced liver injury by a mechanism associated with induction of CYP2E1 , elevated serum [TNF-alpha] levels , and *activation* of . Positive_regulation TNF MAPK6 19493203 2091429 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Positive_regulation TNF MAPK6 19493203 2091455 In conclusion , our data indicate that signaling is *required* to induce maximal [TNF-alpha] production in macrophages during Orientia infection . Positive_regulation TNF MAPK6 19751557 2135279 p38MAPK 's phosphorylation is important in pathogenesis of MODS , and phosphorylation of can *enhance* TNF-alpha mRNA transcription and secretion of [TNF-alpha] from peripheral blood mononuclear cells , which is the mechanism of increased TNF-alpha in MODS . Positive_regulation TNF MAPK6 20010392 2175034 Because p38 ( p38 ) *upregulates* [TNF-alpha] expression and may play a crucial role in pain sensation , we investigated the effect of one injection of inhibitor on expression of the pain related neuropeptide calcitonin gene related peptide (CGRP) . Positive_regulation TNF MAPK6 20068037 2235134 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Positive_regulation TNF MAPK6 20083499 2380897 For the first time , we show that , in fish macrophages , [TNF-a] is processed by TACE-like activity and this cleavage is *dependent* upon the activation of ERK , and JNK signaling pathways by LPS . Positive_regulation TNF MAPK6 20499049 2276363 Expression of [TNF-alpha] and IL-6 in HMC-1 cells treated with bisphenol A is *attenuated* by plant originating glycoprotein ( 75 kDa ) by blocking p38 . Positive_regulation TNF MAPK6 20589681 2334367 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Positive_regulation TNF MAPK6 20646342 2292567 [TNF-alpha] *induced* a significant increase in p38 phosphorylation . Positive_regulation TNF MAPK6 20868379 2337172 [TNF-a] expression was *mediated* in a time dependent manner by p38 , activation of which is under the control of MKP1 . Positive_regulation TNF MAPK6 21208554 2374421 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Positive_regulation TNF MAPK6 21402598 2426931 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Positive_regulation TNF MAPK6 21545687 2554368 [Tumour necrosis factor-a (TNF-a)] significantly *induced* phosphorylation of p38 , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation TNF MAPK6 21642540 2446238 Pretreatment with TAT-SNAP-23 inhibited the increase in plasma membrane expression of gp91(phox) in TNF-a primed neutrophils , whereas [TNF-a] *activation* of ERK1/2 and p38 was not affected . Positive_regulation TNF MAPK6 21849907 2495995 All 3 inhibitors *suppressed* LPS induced [TNF-a] and I-309 expression in human primary monocytes . Positive_regulation TNF MAPK6 22002864 2526305 In this study , we found that inhibition of p38 with SB-203580 ( SB ) *reduced* H ( 2 ) O ( 2 ) -stimulated secretion of [TNF-a] , whereas pre-activation of p38 MAPK with sodium arsenite ( SA ) enhanced H ( 2 ) O ( 2 ) -stimulated secretion of TNF-a . Positive_regulation TNF MAPK6 22343222 2617764 Using immunohistological techniques , we showed a higher epithelial expression of [TNF-a] , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation TNF MAPK6 22385244 2566476 The use of selective inhibitors of signalling pathways revealed that induction of TG2 by IFN-? was mediated by phosphoinositide 3-kinase (PI3K) , while c-Jun N-terminal kinase (JNK) and p38 were *required* for [TNF-a] activation . Positive_regulation TNF MAPK6 22744777 2853450 After LPS administration , all animals displayed increased arterial carbon dioxide partial pressure ( PaCO2 ) and decreased arterial oxygen partial pressure ( PaO2 ) , arterial oxygen saturation ( SO2 ) , HCO3 ( - ) concentration and pH , and *increased* LWCI , MPO activity , interleukin (IL)-1ß , IL-6 and [tumor necrosis factor (TNF)-a] mRNA expression , NF-?B p65 positive staining and p38 activation compared with normal controls ( all P < 0.01 ) . Positive_regulation TNF MAPK6 23188524 2745413 We found that and Akt inhibitors , but not PI3K inhibitor , remarkably *suppressed* ACPA mediated [TNF-a] production . Positive_regulation TNF MAPK6 23354775 2769960 p38a may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , [tumor necrosis factor-a] , interleukin-1ß , and oxidative stress . Positive_regulation TNF MAPK6 23364439 2754527 Conversely , HTS activated p38 mitogen activated protein kinase (MAPK) and enhanced [TNF-a] *activation* of p38 . Positive_regulation TNF MAPK6 23557259 2777808 Inhibition of and CD137 signaling *reduce* dengue virus induced [TNF-a] secretion and apoptosis . Positive_regulation TNF MAPK6 23734186 2796931 Bla g 2 can stimulate up-regulation of inflammatory cytokines including [TNF-alpha] and IL-6 and *activation* of nuclear factor kappa B ( NF-kB/p65 ) , p38 ( p38 ) , ERK , and JNK in cultured fibrocytes . Positive_regulation TNF MAPK6 24089494 2848138 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed [TNF] receptor 1 and *requires* activation of p38 , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation TNF MAPK6 24441870 2922973 On the other hand , [TNF-a] could *induce* Akt and p42/p44 translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation TNF MAPK6 24750790 2936520 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas [TNFalpha] and NO production *required* all three . Positive_regulation TNF MAPK6 7722327 301748 [TNF-alpha] *induces* tyrosine phosphorylation of in adherent human neutrophils . Positive_regulation TNF MAPK6 7722327 301800 These results indicate that [TNF] signaling *involves* activation of . Positive_regulation TNF MAPK6 9148963 430055 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Positive_regulation TNF MAPK6 9418855 480532 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Positive_regulation TNF MAPK6 9439626 482886 These findings suggest a role for [TNF-alpha] in the regulation of intestinal epithelial cell growth and that the mitogenic effect of TNF-alpha *requires* protein tyrosine phosphorylation and activation . Positive_regulation TNF MAPK6 9551930 499084 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , IL-1beta , and [TNF-alpha] , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation TNF MAPK6 9706151 526178 We hypothesized that hydrogen peroxide ( H2O2 ) induces myocardial dysfunction and cardiomyocyte death via P38 *mediated* myocardial [tumor necrosis factor (TNF)] production . Positive_regulation TNF MAPK6 9730957 530350 However , in contrast to the wild-type endotoxin , it failed to induce significant production of [tumor necrosis factor-alpha] and macrophage inflammatory protein-1alpha by monocytes and did not *induce* the phosphorylation and nuclear translocation of . Positive_regulation TNF MAPK6 9766635 538494 [TNF-alpha] and GM-CSF priming of superoxide release stimulated by N-formyl-methionyl-leucyl-phenylalanine was significantly *attenuated* by the MEK inhibitor , PD098059 , and the p38 inhibitor , SB203580 . Positive_regulation TNF MAPK6 9864164 582566 A selective p38 inhibitor , SB203580 , *blocked* [TNF] -- or ceramide induced CREB phosphorylation , but had no effect on the induction of apoptosis mediated by these agents . Positive_regulation TNF MAPK6 9864164 582647 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Positive_regulation TNF MAPK6 9883899 558199 *Activation* of p42/p44 mitogen activated protein kinases (MAPK) and p38 by [tumor necrosis factor (TNF)] is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation TNF MAPK7 10079106 595514 Specific inhibitors of p38alpha *blocked* LPS induced adhesion , nuclear factor-kappa B (NF-kappaB) activation , and synthesis of [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF MAPK7 10079106 595568 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Positive_regulation TNF MAPK7 10079106 595581 These findings support a pathway by which LPS stimulation of neutrophils results in activation of MKK3 , which in turn activates p38alpha , ultimately regulating adhesion , NF-kappaB activation , *enhanced* gene expression of [TNF-alpha] , and regulation of TNF-alpha synthesis . Positive_regulation TNF MAPK7 10210635 607644 ( 1 ) The human heart produces TNF-alpha after I/R , ( 2 ) p38 *mediates* myocardial I/R induced [TNF-alpha] production , ( 3 ) p38 MAPK inhibition limits functional impairment after I/R , and ( 4 ) inhibition of ischemia induced TNF-alpha production may represent a potent therapeutic strategy for improving myocardial function after angioplasty , coronary bypass , or heart transplantation . Positive_regulation TNF MAPK7 10329111 613032 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Positive_regulation TNF MAPK7 10521481 653043 Engagement of tumor necrosis factor (TNF) receptor 1 leads to ATF-2- and p38 *dependent* [TNF-alpha] gene expression . Positive_regulation TNF MAPK7 10521481 653101 The study presented here shows that autoregulation of [TNF-alpha] gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation TNF MAPK7 10586056 571707 Ligation of microglial CD40 results in p44/42 *dependent* [TNF-alpha] production that is opposed by TGF-beta 1 and IL-10 . Positive_regulation TNF MAPK7 10586056 571761 Inhibition of the upstream activator of p44/42 , mitogen activated protein/extracellular signal related kinase kinase 1/2 , with PD98059 , decreases phosphorylation of p44/42 MAPK and significantly *reduces* [TNF-alpha] release following ligation of microglial CD40 . Positive_regulation TNF MAPK7 10601128 574180 [Tumor necrosis factor-alpha (TNF-alpha)] alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation TNF MAPK7 10620700 657674 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Positive_regulation TNF MAPK7 10653605 663299 These results suggest that ( 1 ) while PTK and are *essential* for the production of [TNFalpha] , they are not necessary for the induction of MnSOD by LPS , and ( 2 ) while activation of NFkappaB alone is insufficient for the induction of TNFalpha mRNA by LPS , it is necessary for the induction of TNFalpha as well as MnSOD mRNAs . Positive_regulation TNF MAPK7 10655266 663531 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Positive_regulation TNF MAPK7 10657669 664194 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Positive_regulation TNF MAPK7 10669634 665799 In this study , we show that [TNF-alpha] *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation TNF MAPK7 10783388 707827 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Positive_regulation TNF MAPK7 10857765 704538 These findings indicate that beta2-adrenoceptor stimulation during an LPS challenge prevented [TNF-alpha] production as a *consequence* of inhibition and enhanced cAMP generation , which at a later stage was associated with an anti-inflammatory effect of IL-6 . Positive_regulation TNF MAPK7 11076936 786257 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Positive_regulation TNF MAPK7 11153597 761144 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as [tumour necrosis factor-alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) , in vitro and in vivo by inhibiting p38 . Positive_regulation TNF MAPK7 11221891 787436 Kinase suppressor of ras is necessary for [tumor necrosis factor] alpha *activation* of extracellular signal regulated in intestinal epithelial cells . Positive_regulation TNF MAPK7 11221891 787462 activity is *essential* for [tumor necrosis factor (TNF)] alpha receptor 1 regulation of intestinal epithelial cell proliferation . Positive_regulation TNF MAPK7 11278471 802564 [Tumor necrosis factor-alpha] induction of endothelial ephrin A1 expression is *mediated* by a p38 and SAPK/JNK dependent but nuclear factor-kappa B-independent mechanism . Positive_regulation TNF MAPK7 11299196 803170 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Positive_regulation TNF MAPK7 11443053 833731 Finally , PD-98059 , a p42/44 pathway inhibitor , *blocked* [TNF-alpha] upregulation by eNOS ( P = 0.02 ) . Positive_regulation TNF MAPK7 11443055 833745 p38 *mediates* renal tubular cell [TNF-alpha] production and TNF-alpha dependent apoptosis during simulated ischemia . Positive_regulation TNF MAPK7 11443055 833785 Furthermore , 60 min of ischemia induced renal tubular cell apoptosis at all substrate replacement time points examined , with peak apoptotic cell death occurring after either 24 or 48 h . p38 MAPK inhibition abolished [TNF-alpha] mRNA production and TNF-alpha bioactivity , and both p38 inhibition and TNF-alpha neutralization ( anti-porcine TNF-alpha antibody ) *prevented* apoptosis after 60 min of SI . Positive_regulation TNF MAPK7 11443055 833798 These results constitute the initial demonstration that 1 ) renal tubular cells produce TNF-alpha mRNA and biologically active [TNF-alpha] and undergo apoptosis in response to SI , and 2 ) p38 *mediates* renal tubular cell TNF-alpha production and TNF-alpha dependent apoptosis after SI . Positive_regulation TNF MAPK7 11675371 873181 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Positive_regulation TNF MAPK7 11699878 878395 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Positive_regulation TNF MAPK7 11715476 581276 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Positive_regulation TNF MAPK7 11728947 884762 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Positive_regulation TNF MAPK7 11815388 907599 ( ERK ) blockade ( PD-98059 ) *attenuated* [TNF-alpha] secretion , an effect synergistically amplified in the presence of SB-203580 . Positive_regulation TNF MAPK7 11994432 938942 Evidence for a dual mechanism for IL-10 suppression of [TNF-alpha] production that does not *involve* inhibition of p38 or NF-kappa B in primary human macrophages . Positive_regulation TNF MAPK7 12130576 966554 Phosphorylation of p38 was *induced* by RANKL , IL-1 , [TNFalpha] , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation TNF MAPK7 12391245 1007388 Release of [TNF-alpha] , macrophage-inflammatory protein (MIP)-2 ( MIP-1beta ) , and IL-8 by LPS stimulated neutrophils was also *reduced* by poststimulation p38 inhibition . Positive_regulation TNF MAPK7 12392277 1007667 Inhibition of p38 with SB203580 *inhibited* the production of [TNF-alpha] and IL-10 by LPS stimulated KCs , whereas blockade of ERK1/2 with PD98059 could reduce TNF-alpha production , but did not affect IL-10 production . Positive_regulation TNF MAPK7 12393915 1025406 This model probiotic also inhibits *activation* of the pro-apoptotic by [tumor necrosis factor] , interleukin-1alpha , or gamma-interferon . Positive_regulation TNF MAPK7 12438325 1016569 The activation of protein tyrosine kinases (PTK) and the serine/threonine kinases p38 and ERK was apparently *required* for MTSA-10 induction of [TNF-alpha] and NO release , as revealed by specific kinase inhibitors . Positive_regulation TNF MAPK7 12506117 1056933 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Positive_regulation TNF MAPK7 12631113 1067656 The present data indicate that [TNF-alpha] *activation* of PKCzeta/iota , p42/44 , c-Jun/AP-1 , and p65/NF-kappaB are involved in TNF-alpha stimulated MC fractalkine expression , with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro . Positive_regulation TNF MAPK7 12637577 1099259 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and [tumor necrosis factor alpha (TNFalpha)] *requires* p38 activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation TNF MAPK7 12694807 1080902 [TNF-alpha] *induced* the phosphorylation of p44/p42 and p38 MAP kinase . Positive_regulation TNF MAPK7 12881424 1116123 Importantly , [TNF] does not *induce* ROS accumulation or prolonged activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death Positive_regulation TNF MAPK7 12969251 1139156 Inhibition of the MAP-kinase-kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) pathway , but not that of ( MAPK-p38 ) , *reduced* NO , [TNF-alpha] and IL-6 significantly , suggesting that simultaneous activation of the first two pathways is necessary for the AGE induced induction of these pro-inflammatory stimuli . Positive_regulation TNF MAPK7 14654378 1176819 These findings suggest that the pre-ischemic *activation* of by [TNF] does not contribute to cardioprotection afforded by this agent . Positive_regulation TNF MAPK7 14980980 1220298 The selective p38 inhibitor , SB203580 , *inhibited* the promoter activities of iNOS and COX-2 rather than that of [TNF-alpha] . Positive_regulation TNF MAPK7 15027449 1222856 Apoptosis caused by chronic ethanol treatment may be due to ethanol potentiation of [TNF] *induced* activation of p38 . Positive_regulation TNF MAPK7 15100302 1239724 Previous studies have shown the mitogen activated protein kinases ( MAPKs ) to be activated in macrophages upon infection with Mycobacterium , and that expression of [TNF-alpha] and inducible NO synthase by infected macrophages was *dependent* on activation . Positive_regulation TNF MAPK7 15139014 1246949 The increase in [TNF-alpha] release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation TNF MAPK7 15233873 1269382 A. semen also inhibited the expression of [TNF-alpha] and the *activation* of , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation TNF MAPK7 15248214 1271213 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of [TNFalpha] and IL-1beta by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation TNF MAPK7 15302094 1283842 Selective p42/44 inhibitor could *reduce* the Pb- and LPS triggered [TNF-alpha] expression in U-373MG cells . Positive_regulation TNF MAPK7 15557189 1340415 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Positive_regulation TNF MAPK7 15557189 1340441 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Positive_regulation TNF MAPK7 15592496 1375220 Tenascin-W is found in malignant mammary tumors , promotes alpha8 integrin dependent motility and *requires* activity for BMP-2 and [TNF-alpha] induced expression in vitro . Positive_regulation TNF MAPK7 15614136 1357467 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Positive_regulation TNF MAPK7 15701814 1416532 p38 activation *leads* to increased production of [TNF-alpha] in ischemic injury and in macrophages . Positive_regulation TNF MAPK7 15701814 1416559 Inhibition of p38 activation *led* to inhibition of [TNF-alpha] production . Positive_regulation TNF MAPK7 15703956 1497459 *Activation* of p38 and phosphatidylinositol 3-kinase (PI3K) by [TNF-alpha] was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation TNF MAPK7 15833800 1425443 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Positive_regulation TNF MAPK7 15867183 1404206 In cultured cardiac myocytes , specific activation of stress activated , p38 , by upstream activator MKK6bE *led* to significant induction of [tumor necrosis factor-alpha] and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation TNF MAPK7 15893422 1419736 We also investigated whether specific inhibition of p38 and Erk1/2 would *inhibit* [TNF-alpha] and IL-6 production and thus astrocyte apoptosis , and proliferation , respectively . Positive_regulation TNF MAPK7 15925386 1440377 Our observations show that calcium , activation , HIF-1alpha , and NF-kappaB are *necessary* for ethanol induced [TNF-alpha] and TGF-beta1 expression . Positive_regulation TNF MAPK7 16051807 1438615 Specific inhibitors of p38 significantly *reduced* the H5N1/97 induced [TNF-alpha] expression in macrophages . Positive_regulation TNF MAPK7 16081599 1460341 These results indicate that gp120 elicited [TNF-alpha] production by macrophages *involves* chemokine receptor mediated PI-3K and activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and ERK-1/2 independently regulate TNF-alpha production . Positive_regulation TNF MAPK7 16271232 1479209 Similarly , the increased gene expression of proinflammatory cytokines [TNF-alpha] and IL-1beta in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation TNF MAPK7 16275991 1480274 Angiotensin II , [tumor necrosis factor-alpha] , or epidermal growth factor *induced* phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation TNF MAPK7 16291729 1526059 *Activation* of and Akt by anti-HER2/neu [ScFv-TNF-alpha] inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation TNF MAPK7 16403817 1540132 The [TNF] + dex stimulated increase in leptin was associated with an increase in p38 MAPK activity and was totally *blocked* by p38 inhibitors . Positive_regulation TNF MAPK7 16438946 1495433 Although gAd partially increased cAMP concentration and PKA activity , it directly reduced leptin induced ERK1/2 and p38 phosphorylation thus *inhibiting* [TNF-alpha] production . Positive_regulation TNF MAPK7 16480618 1496071 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Positive_regulation TNF MAPK7 16480618 1496110 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Positive_regulation TNF MAPK7 16517732 1530909 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of [TNF] , but not IL-6 , *requires* the activity of p38 . Positive_regulation TNF MAPK7 16573652 1556128 HA-mediated [TNF-alpha] production *required* p38 , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation TNF MAPK7 16581537 1543742 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Positive_regulation TNF MAPK7 16596287 1544888 These results collectively reveal that AV-ext *inhibits* [TNF-alpha] release from macrophages by suppressing and NF-kappaB signaling pathways and suggest that AV-ext may be beneficial for the treatment of endotoxin shock or sepsis . Positive_regulation TNF MAPK7 16771851 1572711 this process then leads to modulation of p38 *dependent* IL-8 and [TNF-alpha] release from the epithelium . Positive_regulation TNF MAPK7 16781693 1585607 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and [TNF-alpha] and the *activation* of 's are potentially positive signals for IL-10 production . Positive_regulation TNF MAPK7 16867160 1592840 Further , the activation of p38 and extracellular signal regulated kinase was *required* for the induction of [TNF-alpha] and IL-6 by MTB12 , as well as by the 30-kDa Ag . Positive_regulation TNF MAPK7 17032936 1692728 The stimulation of [TNF-alpha] production was *dependent* on cisplatin induced activation of p38 and was associated with phosphorylation of the translation initiation factor eIF4E and its upstream kinase Mnk1 . Positive_regulation TNF MAPK7 17032936 1692741 Inhibition of p38 and , to a lesser extent , ERK , *reduced* cisplatin+endotoxin stimulated [TNF-alpha] production and phosphorylation of Mnk1 and eIF4E . Positive_regulation TNF MAPK7 17074860 1675549 B. burgdorferi induced [TNF-alpha] production is also *dependent* on the activation of p38 . Positive_regulation TNF MAPK7 17117477 1677361 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Positive_regulation TNF MAPK7 17126905 1686521 Differential regulation of [TNFalpha] and GM-CSF *induced* activation of P38 in neutrophils and eosinophils . Positive_regulation TNF MAPK7 17131360 1700735 In addition , we recently found that p38 *mediates* [TNF-alpha] upregulation of atrogin-1/MAFbx expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation TNF MAPK7 17138860 1653564 The purpose of this study was to determine whether the , ERK1/2 , and p38 MAPK are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Positive_regulation TNF MAPK7 17172975 1679378 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK7 17172975 1679404 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK7 17202326 1680806 Augmented lipopolysaccharide induced [TNF-alpha] production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK7 17202326 1680832 In this study , we show that augmented LPS induced [TNF-alpha] production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK7 17395780 1766153 Here we demonstrate that Rab7b can negatively regulate lipopolysaccharide (LPS) induced production of [tumor necrosis factor (TNF)-alpha] , IL-6 , nitric oxide , and IFN-beta , and potentiate LPS induced *activation* of , nuclear factor kappaB , and IFN regulatory factor 3 signaling pathways in macrophages by promoting the degradation of TLR4 . Positive_regulation TNF MAPK7 17438131 1742747 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by [TNF-alpha] and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation TNF MAPK7 17553937 1791999 Twenty-four hours thereafter , splenic macrophages were isolated , and their IL-6 and [TNF-alpha] production and *activation* of and NF-kappaB were measured . Positive_regulation TNF MAPK7 17607712 1798179 Although [TNF] *induced* the activation of p38 , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation TNF MAPK7 17902045 1835080 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Positive_regulation TNF MAPK7 17934341 1813487 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Positive_regulation TNF MAPK7 17940160 1888987 Conversely , Ser phosphorylation of IRS-2 mediated by [TNF-alpha] *activation* of was the mechanism found in brown adipocytes . Positive_regulation TNF MAPK7 17964662 1831053 Taken together , these results suggest that linomide *inhibits* [TNF-alpha] production by suppressing the activation of NF-kappaB and , which might , at least in part , contribute to the beneficial effects of linomide in the treatment of autoimmune diseases . Positive_regulation TNF MAPK7 17994109 1851148 [TNF-alpha] triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation TNF MAPK7 18227157 1884337 It was shown that these three proteins could ( i ) induce expression of [tumor necrosis factor alpha (TNF-alpha)] and tissue factor and ( ii ) *induce* phosphorylation of p44/42 and activation of early growth response factor 1 (Egr-1) . Positive_regulation TNF MAPK7 18296636 1878864 Whereas the induction of [TNFalpha] , IL-1beta , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation TNF MAPK7 18303184 1873527 Inhibition of p38 activation selectively *blocked* DNCB induced [TNF-alpha] release , but not NiSO ( 4 ) -induced release . Positive_regulation TNF MAPK7 18314537 1919437 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Positive_regulation TNF MAPK7 18390808 1925670 We tested the hypothesis that p38 activation is *necessary* for [TNF-alpha] production , neutrophil activation , and subsequent liver injury . Positive_regulation TNF MAPK7 18622138 1984362 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Positive_regulation TNF MAPK7 18675993 2011333 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Positive_regulation TNF MAPK7 19002259 1991235 Peptidoglycan stimulated monocyte p38 and p38 activity was *required* for [TNFalpha] production by the cells . Positive_regulation TNF MAPK7 19040616 2017411 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Positive_regulation TNF MAPK7 19043204 1998824 Moreover , [TNF-alpha] production was *prevented* by NF-kappaB and inhibitors . Positive_regulation TNF MAPK7 19052649 1999790 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Positive_regulation TNF MAPK7 19250666 2055381 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Positive_regulation TNF MAPK7 19267548 2045606 Since activated p38 *mediates* [TNF-alpha] production , we examined the effect of radiation on LPS induced activation of p38 MAPK and TNF-alpha production . Positive_regulation TNF MAPK7 19287189 2046608 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Positive_regulation TNF MAPK7 19351958 2088783 Specific inhibitors of p38 and glycogen synthase kinase 3 *suppressed* [TNF-alpha] production and maturation of fucoidan treated PBDCs . Positive_regulation TNF MAPK7 19427347 2106786 [TNF-alpha] *induced* the phosphorylation of p38 , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation TNF MAPK7 19477265 2107664 These results show that chronic ethanol feeding enhances Fas induced liver injury by a mechanism associated with induction of CYP2E1 , elevated serum [TNF-alpha] levels , and *activation* of . Positive_regulation TNF MAPK7 19493203 2091430 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Positive_regulation TNF MAPK7 19493203 2091456 In conclusion , our data indicate that signaling is *required* to induce maximal [TNF-alpha] production in macrophages during Orientia infection . Positive_regulation TNF MAPK7 19751557 2135280 p38MAPK 's phosphorylation is important in pathogenesis of MODS , and phosphorylation of can *enhance* TNF-alpha mRNA transcription and secretion of [TNF-alpha] from peripheral blood mononuclear cells , which is the mechanism of increased TNF-alpha in MODS . Positive_regulation TNF MAPK7 20010392 2175035 Because p38 ( p38 ) *upregulates* [TNF-alpha] expression and may play a crucial role in pain sensation , we investigated the effect of one injection of inhibitor on expression of the pain related neuropeptide calcitonin gene related peptide (CGRP) . Positive_regulation TNF MAPK7 20068037 2235135 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Positive_regulation TNF MAPK7 20083499 2380898 For the first time , we show that , in fish macrophages , [TNF-a] is processed by TACE-like activity and this cleavage is *dependent* upon the activation of ERK , and JNK signaling pathways by LPS . Positive_regulation TNF MAPK7 20499049 2276364 Expression of [TNF-alpha] and IL-6 in HMC-1 cells treated with bisphenol A is *attenuated* by plant originating glycoprotein ( 75 kDa ) by blocking p38 . Positive_regulation TNF MAPK7 20589681 2334368 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Positive_regulation TNF MAPK7 20646342 2292568 [TNF-alpha] *induced* a significant increase in p38 phosphorylation . Positive_regulation TNF MAPK7 20868379 2337173 [TNF-a] expression was *mediated* in a time dependent manner by p38 , activation of which is under the control of MKP1 . Positive_regulation TNF MAPK7 21166929 2385272 MEK5 is activated by shear stress , activates and *induces* KLF4 to modulate [TNF] responses in human dermal microvascular endothelial cells . Positive_regulation TNF MAPK7 21208554 2374422 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Positive_regulation TNF MAPK7 21402598 2426932 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Positive_regulation TNF MAPK7 21545687 2554369 [Tumour necrosis factor-a (TNF-a)] significantly *induced* phosphorylation of p38 , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation TNF MAPK7 21642540 2446239 Pretreatment with TAT-SNAP-23 inhibited the increase in plasma membrane expression of gp91(phox) in TNF-a primed neutrophils , whereas [TNF-a] *activation* of ERK1/2 and p38 was not affected . Positive_regulation TNF MAPK7 21849907 2495996 All 3 inhibitors *suppressed* LPS induced [TNF-a] and I-309 expression in human primary monocytes . Positive_regulation TNF MAPK7 22002864 2526306 In this study , we found that inhibition of p38 with SB-203580 ( SB ) *reduced* H ( 2 ) O ( 2 ) -stimulated secretion of TNF-a , whereas pre-activation of p38 MAPK with sodium arsenite ( SA ) enhanced H ( 2 ) O ( 2 ) -stimulated secretion of [TNF-a] . Positive_regulation TNF MAPK7 22343222 2617765 Using immunohistological techniques , we showed a higher epithelial expression of [TNF-a] , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation TNF MAPK7 22385244 2566477 The use of selective inhibitors of signalling pathways revealed that induction of TG2 by IFN-? was mediated by phosphoinositide 3-kinase (PI3K) , while c-Jun N-terminal kinase (JNK) and p38 were *required* for [TNF-a] activation . Positive_regulation TNF MAPK7 22744777 2853451 After LPS administration , all animals displayed increased arterial carbon dioxide partial pressure ( PaCO2 ) and decreased arterial oxygen partial pressure ( PaO2 ) , arterial oxygen saturation ( SO2 ) , HCO3 ( - ) concentration and pH , and *increased* LWCI , MPO activity , interleukin (IL)-1ß , IL-6 and [tumor necrosis factor (TNF)-a] mRNA expression , NF-?B p65 positive staining and p38 activation compared with normal controls ( all P < 0.01 ) . Positive_regulation TNF MAPK7 23188524 2745414 We found that and Akt inhibitors , but not PI3K inhibitor , remarkably *suppressed* ACPA mediated [TNF-a] production . Positive_regulation TNF MAPK7 23354775 2769961 p38a may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , [tumor necrosis factor-a] , interleukin-1ß , and oxidative stress . Positive_regulation TNF MAPK7 23364439 2754528 Conversely , HTS activated p38 mitogen activated protein kinase (MAPK) and enhanced [TNF-a] *activation* of p38 . Positive_regulation TNF MAPK7 23557259 2777809 Inhibition of and CD137 signaling *reduce* dengue virus induced [TNF-a] secretion and apoptosis . Positive_regulation TNF MAPK7 23734186 2796932 Bla g 2 can stimulate up-regulation of inflammatory cytokines including [TNF-alpha] and IL-6 and *activation* of nuclear factor kappa B ( NF-kB/p65 ) , p38 ( p38 ) , ERK , and JNK in cultured fibrocytes . Positive_regulation TNF MAPK7 24089494 2848139 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed [TNF] receptor 1 and *requires* activation of p38 , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation TNF MAPK7 24441870 2922974 On the other hand , [TNF-a] could *induce* Akt and p42/p44 translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation TNF MAPK7 24750790 2936521 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas [TNFalpha] and NO production *required* all three . Positive_regulation TNF MAPK7 7722327 301749 [TNF-alpha] *induces* tyrosine phosphorylation of in adherent human neutrophils . Positive_regulation TNF MAPK7 7722327 301801 These results indicate that [TNF] signaling *involves* activation of . Positive_regulation TNF MAPK7 9148963 430056 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Positive_regulation TNF MAPK7 9418855 480533 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Positive_regulation TNF MAPK7 9439626 482887 These findings suggest a role for [TNF-alpha] in the regulation of intestinal epithelial cell growth and that the mitogenic effect of TNF-alpha *requires* protein tyrosine phosphorylation and activation . Positive_regulation TNF MAPK7 9551930 499085 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , IL-1beta , and [TNF-alpha] , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation TNF MAPK7 9706151 526179 We hypothesized that hydrogen peroxide ( H2O2 ) induces myocardial dysfunction and cardiomyocyte death via P38 *mediated* myocardial [tumor necrosis factor (TNF)] production . Positive_regulation TNF MAPK7 9730957 530351 However , in contrast to the wild-type endotoxin , it failed to induce significant production of [tumor necrosis factor-alpha] and macrophage inflammatory protein-1alpha by monocytes and did not *induce* the phosphorylation and nuclear translocation of . Positive_regulation TNF MAPK7 9766635 538495 [TNF-alpha] and GM-CSF priming of superoxide release stimulated by N-formyl-methionyl-leucyl-phenylalanine was significantly *attenuated* by the MEK inhibitor , PD098059 , and the p38 inhibitor , SB203580 . Positive_regulation TNF MAPK7 9864164 582567 A selective p38 inhibitor , SB203580 , *blocked* [TNF] -- or ceramide induced CREB phosphorylation , but had no effect on the induction of apoptosis mediated by these agents . Positive_regulation TNF MAPK7 9864164 582648 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Positive_regulation TNF MAPK7 9883899 558200 *Activation* of p42/p44 and p38 MAPK by [tumor necrosis factor (TNF)] is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation TNF MAPK8 10079106 595515 Specific inhibitors of p38alpha *blocked* LPS induced adhesion , nuclear factor-kappa B (NF-kappaB) activation , and synthesis of [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF MAPK8 10079106 595569 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Positive_regulation TNF MAPK8 10079106 595582 These findings support a pathway by which LPS stimulation of neutrophils results in activation of MKK3 , which in turn activates p38alpha , ultimately regulating adhesion , NF-kappaB activation , *enhanced* gene expression of [TNF-alpha] , and regulation of TNF-alpha synthesis . Positive_regulation TNF MAPK8 10210635 607645 ( 1 ) The human heart produces TNF-alpha after I/R , ( 2 ) p38 *mediates* myocardial I/R induced [TNF-alpha] production , ( 3 ) p38 MAPK inhibition limits functional impairment after I/R , and ( 4 ) inhibition of ischemia induced TNF-alpha production may represent a potent therapeutic strategy for improving myocardial function after angioplasty , coronary bypass , or heart transplantation . Positive_regulation TNF MAPK8 10329111 613033 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Positive_regulation TNF MAPK8 10521481 653044 Engagement of tumor necrosis factor (TNF) receptor 1 leads to ATF-2- and p38 *dependent* [TNF-alpha] gene expression . Positive_regulation TNF MAPK8 10521481 653102 The study presented here shows that autoregulation of [TNF-alpha] gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation TNF MAPK8 10586056 571708 Ligation of microglial CD40 results in p44/42 *dependent* [TNF-alpha] production that is opposed by TGF-beta 1 and IL-10 . Positive_regulation TNF MAPK8 10586056 571762 Inhibition of the upstream activator of p44/42 , mitogen activated protein/extracellular signal related kinase kinase 1/2 , with PD98059 , decreases phosphorylation of p44/42 MAPK and significantly *reduces* [TNF-alpha] release following ligation of microglial CD40 . Positive_regulation TNF MAPK8 10601128 574181 [Tumor necrosis factor-alpha (TNF-alpha)] alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation TNF MAPK8 10620700 657675 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Positive_regulation TNF MAPK8 10653605 663300 These results suggest that ( 1 ) while PTK and are *essential* for the production of [TNFalpha] , they are not necessary for the induction of MnSOD by LPS , and ( 2 ) while activation of NFkappaB alone is insufficient for the induction of TNFalpha mRNA by LPS , it is necessary for the induction of TNFalpha as well as MnSOD mRNAs . Positive_regulation TNF MAPK8 10655266 663532 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Positive_regulation TNF MAPK8 10657669 664195 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Positive_regulation TNF MAPK8 10669634 665800 In this study , we show that [TNF-alpha] *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation TNF MAPK8 10783388 707828 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Positive_regulation TNF MAPK8 10857765 704539 These findings indicate that beta2-adrenoceptor stimulation during an LPS challenge prevented [TNF-alpha] production as a *consequence* of inhibition and enhanced cAMP generation , which at a later stage was associated with an anti-inflammatory effect of IL-6 . Positive_regulation TNF MAPK8 11076936 786258 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Positive_regulation TNF MAPK8 11153597 761145 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as [tumour necrosis factor-alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) , in vitro and in vivo by inhibiting p38 . Positive_regulation TNF MAPK8 11221891 787437 Kinase suppressor of ras is necessary for [tumor necrosis factor] alpha *activation* of extracellular signal regulated in intestinal epithelial cells . Positive_regulation TNF MAPK8 11221891 787463 activity is *essential* for [tumor necrosis factor (TNF)] alpha receptor 1 regulation of intestinal epithelial cell proliferation . Positive_regulation TNF MAPK8 11278471 802565 [Tumor necrosis factor-alpha] induction of endothelial ephrin A1 expression is *mediated* by a p38 and SAPK/JNK dependent but nuclear factor-kappa B-independent mechanism . Positive_regulation TNF MAPK8 11299196 803171 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Positive_regulation TNF MAPK8 11443053 833732 Finally , PD-98059 , a p42/44 pathway inhibitor , *blocked* [TNF-alpha] upregulation by eNOS ( P = 0.02 ) . Positive_regulation TNF MAPK8 11443055 833746 p38 *mediates* renal tubular cell [TNF-alpha] production and TNF-alpha dependent apoptosis during simulated ischemia . Positive_regulation TNF MAPK8 11443055 833786 Furthermore , 60 min of ischemia induced renal tubular cell apoptosis at all substrate replacement time points examined , with peak apoptotic cell death occurring after either 24 or 48 h . p38 MAPK inhibition abolished [TNF-alpha] mRNA production and TNF-alpha bioactivity , and both p38 inhibition and TNF-alpha neutralization ( anti-porcine TNF-alpha antibody ) *prevented* apoptosis after 60 min of SI . Positive_regulation TNF MAPK8 11443055 833799 These results constitute the initial demonstration that 1 ) renal tubular cells produce TNF-alpha mRNA and biologically active [TNF-alpha] and undergo apoptosis in response to SI , and 2 ) p38 *mediates* renal tubular cell TNF-alpha production and TNF-alpha dependent apoptosis after SI . Positive_regulation TNF MAPK8 11675371 873182 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Positive_regulation TNF MAPK8 11699878 878396 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Positive_regulation TNF MAPK8 11715476 581277 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Positive_regulation TNF MAPK8 11728947 884763 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Positive_regulation TNF MAPK8 11815388 907600 ( ERK ) blockade ( PD-98059 ) *attenuated* [TNF-alpha] secretion , an effect synergistically amplified in the presence of SB-203580 . Positive_regulation TNF MAPK8 11994432 938943 Evidence for a dual mechanism for IL-10 suppression of [TNF-alpha] production that does not *involve* inhibition of p38 or NF-kappa B in primary human macrophages . Positive_regulation TNF MAPK8 12130576 966555 Phosphorylation of p38 was *induced* by RANKL , IL-1 , [TNFalpha] , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation TNF MAPK8 12391245 1007389 Release of [TNF-alpha] , macrophage-inflammatory protein (MIP)-2 ( MIP-1beta ) , and IL-8 by LPS stimulated neutrophils was also *reduced* by poststimulation p38 inhibition . Positive_regulation TNF MAPK8 12392277 1007668 Inhibition of p38 with SB203580 *inhibited* the production of [TNF-alpha] and IL-10 by LPS stimulated KCs , whereas blockade of ERK1/2 with PD98059 could reduce TNF-alpha production , but did not affect IL-10 production . Positive_regulation TNF MAPK8 12393915 1025407 This model probiotic also inhibits *activation* of the pro-apoptotic by [tumor necrosis factor] , interleukin-1alpha , or gamma-interferon . Positive_regulation TNF MAPK8 12438325 1016570 The activation of protein tyrosine kinases (PTK) and the serine/threonine kinases p38 and ERK was apparently *required* for MTSA-10 induction of [TNF-alpha] and NO release , as revealed by specific kinase inhibitors . Positive_regulation TNF MAPK8 12506117 1056934 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Positive_regulation TNF MAPK8 12631113 1067657 The present data indicate that [TNF-alpha] *activation* of PKCzeta/iota , p42/44 , c-Jun/AP-1 , and p65/NF-kappaB are involved in TNF-alpha stimulated MC fractalkine expression , with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro . Positive_regulation TNF MAPK8 12637577 1099260 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and [tumor necrosis factor alpha (TNFalpha)] *requires* p38 activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation TNF MAPK8 12694807 1080903 [TNF-alpha] *induced* the phosphorylation of p44/p42 and p38 MAP kinase . Positive_regulation TNF MAPK8 12881424 1116124 Importantly , [TNF] does not *induce* ROS accumulation or prolonged activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death Positive_regulation TNF MAPK8 12969251 1139157 Inhibition of the MAP-kinase-kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) pathway , but not that of ( MAPK-p38 ) , *reduced* NO , [TNF-alpha] and IL-6 significantly , suggesting that simultaneous activation of the first two pathways is necessary for the AGE induced induction of these pro-inflammatory stimuli . Positive_regulation TNF MAPK8 14654378 1176820 These findings suggest that the pre-ischemic *activation* of by [TNF] does not contribute to cardioprotection afforded by this agent . Positive_regulation TNF MAPK8 14980980 1220299 The selective p38 inhibitor , SB203580 , *inhibited* the promoter activities of iNOS and COX-2 rather than that of [TNF-alpha] . Positive_regulation TNF MAPK8 15027449 1222857 Apoptosis caused by chronic ethanol treatment may be due to ethanol potentiation of [TNF] *induced* activation of p38 . Positive_regulation TNF MAPK8 15100302 1239725 Previous studies have shown the mitogen activated protein kinases ( MAPKs ) to be activated in macrophages upon infection with Mycobacterium , and that expression of [TNF-alpha] and inducible NO synthase by infected macrophages was *dependent* on activation . Positive_regulation TNF MAPK8 15139014 1246950 The increase in [TNF-alpha] release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation TNF MAPK8 15233873 1269383 A. semen also inhibited the expression of [TNF-alpha] and the *activation* of , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation TNF MAPK8 15248214 1271214 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of [TNFalpha] and IL-1beta by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation TNF MAPK8 15302094 1283843 Selective p42/44 inhibitor could *reduce* the Pb- and LPS triggered [TNF-alpha] expression in U-373MG cells . Positive_regulation TNF MAPK8 15557189 1340416 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Positive_regulation TNF MAPK8 15557189 1340442 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Positive_regulation TNF MAPK8 15592496 1375221 Tenascin-W is found in malignant mammary tumors , promotes alpha8 integrin dependent motility and *requires* activity for BMP-2 and [TNF-alpha] induced expression in vitro . Positive_regulation TNF MAPK8 15614136 1357468 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Positive_regulation TNF MAPK8 15701814 1416533 p38 activation *leads* to increased production of [TNF-alpha] in ischemic injury and in macrophages . Positive_regulation TNF MAPK8 15701814 1416560 Inhibition of p38 activation *led* to inhibition of [TNF-alpha] production . Positive_regulation TNF MAPK8 15703956 1497460 *Activation* of p38 and phosphatidylinositol 3-kinase (PI3K) by [TNF-alpha] was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation TNF MAPK8 15833800 1425444 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Positive_regulation TNF MAPK8 15867183 1404207 In cultured cardiac myocytes , specific activation of stress activated , p38 , by upstream activator MKK6bE *led* to significant induction of [tumor necrosis factor-alpha] and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation TNF MAPK8 15893422 1419737 We also investigated whether specific inhibition of p38 and Erk1/2 would *inhibit* [TNF-alpha] and IL-6 production and thus astrocyte apoptosis , and proliferation , respectively . Positive_regulation TNF MAPK8 15925386 1440378 Our observations show that calcium , activation , HIF-1alpha , and NF-kappaB are *necessary* for ethanol induced [TNF-alpha] and TGF-beta1 expression . Positive_regulation TNF MAPK8 16051807 1438616 Specific inhibitors of p38 significantly *reduced* the H5N1/97 induced [TNF-alpha] expression in macrophages . Positive_regulation TNF MAPK8 16081599 1460342 These results indicate that gp120 elicited [TNF-alpha] production by macrophages *involves* chemokine receptor mediated PI-3K and activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and ERK-1/2 independently regulate TNF-alpha production . Positive_regulation TNF MAPK8 16271232 1479210 Similarly , the increased gene expression of proinflammatory cytokines [TNF-alpha] and IL-1beta in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation TNF MAPK8 16275991 1480275 Angiotensin II , [tumor necrosis factor-alpha] , or epidermal growth factor *induced* phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation TNF MAPK8 16291729 1526060 *Activation* of and Akt by anti-HER2/neu [ScFv-TNF-alpha] inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation TNF MAPK8 16403817 1540133 The [TNF] + dex stimulated increase in leptin was associated with an increase in p38 MAPK activity and was totally *blocked* by p38 inhibitors . Positive_regulation TNF MAPK8 16438946 1495434 Although gAd partially increased cAMP concentration and PKA activity , it directly reduced leptin induced ERK1/2 and p38 phosphorylation thus *inhibiting* [TNF-alpha] production . Positive_regulation TNF MAPK8 16480618 1496072 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Positive_regulation TNF MAPK8 16480618 1496111 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Positive_regulation TNF MAPK8 16517732 1530910 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of [TNF] , but not IL-6 , *requires* the activity of p38 . Positive_regulation TNF MAPK8 16573652 1556129 HA-mediated [TNF-alpha] production *required* p38 , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation TNF MAPK8 16581537 1543743 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Positive_regulation TNF MAPK8 16596287 1544889 These results collectively reveal that AV-ext *inhibits* [TNF-alpha] release from macrophages by suppressing and NF-kappaB signaling pathways and suggest that AV-ext may be beneficial for the treatment of endotoxin shock or sepsis . Positive_regulation TNF MAPK8 16771851 1572712 this process then leads to modulation of p38 *dependent* IL-8 and [TNF-alpha] release from the epithelium . Positive_regulation TNF MAPK8 16781693 1585608 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and [TNF-alpha] and the *activation* of 's are potentially positive signals for IL-10 production . Positive_regulation TNF MAPK8 16867160 1592841 Further , the activation of p38 and extracellular signal regulated kinase was *required* for the induction of [TNF-alpha] and IL-6 by MTB12 , as well as by the 30-kDa Ag . Positive_regulation TNF MAPK8 17032936 1692729 The stimulation of [TNF-alpha] production was *dependent* on cisplatin induced activation of p38 and was associated with phosphorylation of the translation initiation factor eIF4E and its upstream kinase Mnk1 . Positive_regulation TNF MAPK8 17032936 1692742 Inhibition of p38 and , to a lesser extent , ERK , *reduced* cisplatin+endotoxin stimulated [TNF-alpha] production and phosphorylation of Mnk1 and eIF4E . Positive_regulation TNF MAPK8 17074860 1675550 B. burgdorferi induced [TNF-alpha] production is also *dependent* on the activation of p38 . Positive_regulation TNF MAPK8 17117477 1677362 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Positive_regulation TNF MAPK8 17126905 1686522 Differential regulation of [TNFalpha] and GM-CSF *induced* activation of P38 in neutrophils and eosinophils . Positive_regulation TNF MAPK8 17131360 1700736 In addition , we recently found that p38 *mediates* [TNF-alpha] upregulation of atrogin-1/MAFbx expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation TNF MAPK8 17138860 1653565 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Positive_regulation TNF MAPK8 17172975 1679379 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK8 17172975 1679405 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK8 17202326 1680807 Augmented lipopolysaccharide induced [TNF-alpha] production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK8 17202326 1680833 In this study , we show that augmented LPS induced [TNF-alpha] production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK8 17395780 1766154 Here we demonstrate that Rab7b can negatively regulate lipopolysaccharide (LPS) induced production of [tumor necrosis factor (TNF)-alpha] , IL-6 , nitric oxide , and IFN-beta , and potentiate LPS induced *activation* of , nuclear factor kappaB , and IFN regulatory factor 3 signaling pathways in macrophages by promoting the degradation of TLR4 . Positive_regulation TNF MAPK8 17438131 1742748 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by [TNF-alpha] and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation TNF MAPK8 17553937 1792000 Twenty-four hours thereafter , splenic macrophages were isolated , and their IL-6 and [TNF-alpha] production and *activation* of and NF-kappaB were measured . Positive_regulation TNF MAPK8 17607712 1798180 Although [TNF] *induced* the activation of p38 , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation TNF MAPK8 17902045 1835081 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Positive_regulation TNF MAPK8 17934341 1813488 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Positive_regulation TNF MAPK8 17940160 1888988 Conversely , Ser phosphorylation of IRS-2 mediated by [TNF-alpha] *activation* of was the mechanism found in brown adipocytes . Positive_regulation TNF MAPK8 17964662 1831054 Taken together , these results suggest that linomide *inhibits* [TNF-alpha] production by suppressing the activation of NF-kappaB and , which might , at least in part , contribute to the beneficial effects of linomide in the treatment of autoimmune diseases . Positive_regulation TNF MAPK8 17994109 1851149 [TNF-alpha] triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation TNF MAPK8 18227157 1884338 It was shown that these three proteins could ( i ) induce expression of [tumor necrosis factor alpha (TNF-alpha)] and tissue factor and ( ii ) *induce* phosphorylation of p44/42 and activation of early growth response factor 1 (Egr-1) . Positive_regulation TNF MAPK8 18296636 1878865 Whereas the induction of [TNFalpha] , IL-1beta , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation TNF MAPK8 18303184 1873528 Inhibition of p38 activation selectively *blocked* DNCB induced [TNF-alpha] release , but not NiSO ( 4 ) -induced release . Positive_regulation TNF MAPK8 18314537 1919438 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Positive_regulation TNF MAPK8 18390808 1925671 We tested the hypothesis that p38 activation is *necessary* for [TNF-alpha] production , neutrophil activation , and subsequent liver injury . Positive_regulation TNF MAPK8 18622138 1984363 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Positive_regulation TNF MAPK8 18675993 2011334 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Positive_regulation TNF MAPK8 19002259 1991236 Peptidoglycan stimulated monocyte p38 and p38 activity was *required* for [TNFalpha] production by the cells . Positive_regulation TNF MAPK8 19040616 2017412 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Positive_regulation TNF MAPK8 19043204 1998825 Moreover , [TNF-alpha] production was *prevented* by NF-kappaB and inhibitors . Positive_regulation TNF MAPK8 19052649 1999791 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Positive_regulation TNF MAPK8 19250666 2055382 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Positive_regulation TNF MAPK8 19267548 2045607 Since activated p38 *mediates* [TNF-alpha] production , we examined the effect of radiation on LPS induced activation of p38 MAPK and TNF-alpha production . Positive_regulation TNF MAPK8 19287189 2046609 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Positive_regulation TNF MAPK8 19351958 2088784 Specific inhibitors of p38 and glycogen synthase kinase 3 *suppressed* [TNF-alpha] production and maturation of fucoidan treated PBDCs . Positive_regulation TNF MAPK8 19427347 2106787 [TNF-alpha] *induced* the phosphorylation of p38 , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation TNF MAPK8 19477265 2107665 These results show that chronic ethanol feeding enhances Fas induced liver injury by a mechanism associated with induction of CYP2E1 , elevated serum [TNF-alpha] levels , and *activation* of . Positive_regulation TNF MAPK8 19493203 2091431 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Positive_regulation TNF MAPK8 19493203 2091457 In conclusion , our data indicate that signaling is *required* to induce maximal [TNF-alpha] production in macrophages during Orientia infection . Positive_regulation TNF MAPK8 19751557 2135281 p38MAPK 's phosphorylation is important in pathogenesis of MODS , and phosphorylation of can *enhance* TNF-alpha mRNA transcription and secretion of [TNF-alpha] from peripheral blood mononuclear cells , which is the mechanism of increased TNF-alpha in MODS . Positive_regulation TNF MAPK8 20010392 2175036 Because p38 ( p38 ) *upregulates* [TNF-alpha] expression and may play a crucial role in pain sensation , we investigated the effect of one injection of inhibitor on expression of the pain related neuropeptide calcitonin gene related peptide (CGRP) . Positive_regulation TNF MAPK8 20068037 2235136 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Positive_regulation TNF MAPK8 20083499 2380899 For the first time , we show that , in fish macrophages , [TNF-a] is processed by TACE-like activity and this cleavage is *dependent* upon the activation of ERK , and JNK signaling pathways by LPS . Positive_regulation TNF MAPK8 20196785 2180969 These findings suggest that E ( 2 ) , BSA-E ( 2 ) and ERalpha expression exert their cardioprotective effects by inhibiting mediated LPS *induced* [TNF-alpha] expression and cardiomyocyte apoptosis through activation of Akt . Positive_regulation TNF MAPK8 20499049 2276365 Expression of [TNF-alpha] and IL-6 in HMC-1 cells treated with bisphenol A is *attenuated* by plant originating glycoprotein ( 75 kDa ) by blocking p38 . Positive_regulation TNF MAPK8 20522023 2295344 For instance , all morbidly obese patients , irrespective of their insulin resistance , showed increased expression of [TNFalpha] ( tumour necrosis factor alpha ) and *activation* of ( c-Jun N-terminal kinase 1/2 ) . Positive_regulation TNF MAPK8 20589681 2334369 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Positive_regulation TNF MAPK8 20646342 2292569 [TNF-alpha] *induced* a significant increase in p38 phosphorylation . Positive_regulation TNF MAPK8 20868379 2337174 [TNF-a] expression was *mediated* in a time dependent manner by p38 , activation of which is under the control of MKP1 . Positive_regulation TNF MAPK8 21208554 2374423 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Positive_regulation TNF MAPK8 21402598 2426933 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Positive_regulation TNF MAPK8 21545687 2554370 [Tumour necrosis factor-a (TNF-a)] significantly *induced* phosphorylation of p38 , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation TNF MAPK8 21642540 2446240 Pretreatment with TAT-SNAP-23 inhibited the increase in plasma membrane expression of gp91(phox) in TNF-a primed neutrophils , whereas [TNF-a] *activation* of ERK1/2 and p38 was not affected . Positive_regulation TNF MAPK8 21849907 2495997 All 3 inhibitors *suppressed* LPS induced [TNF-a] and I-309 expression in human primary monocytes . Positive_regulation TNF MAPK8 22002864 2526307 In this study , we found that inhibition of p38 with SB-203580 ( SB ) *reduced* H ( 2 ) O ( 2 ) -stimulated secretion of [TNF-a] , whereas pre-activation of p38 MAPK with sodium arsenite ( SA ) enhanced H ( 2 ) O ( 2 ) -stimulated secretion of TNF-a . Positive_regulation TNF MAPK8 22182512 2543290 The plasmid transfected cells *enhanced* [TNF-a] up-regulation of IRF-1 whereas JNK1 overexpressing cells displayed down-regulation ; Positive_regulation TNF MAPK8 22343222 2617766 Using immunohistological techniques , we showed a higher epithelial expression of [TNF-a] , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation TNF MAPK8 22385244 2566478 The use of selective inhibitors of signalling pathways revealed that induction of TG2 by IFN-? was mediated by phosphoinositide 3-kinase (PI3K) , while c-Jun N-terminal kinase (JNK) and p38 were *required* for [TNF-a] activation . Positive_regulation TNF MAPK8 22744777 2853452 After LPS administration , all animals displayed increased arterial carbon dioxide partial pressure ( PaCO2 ) and decreased arterial oxygen partial pressure ( PaO2 ) , arterial oxygen saturation ( SO2 ) , HCO3 ( - ) concentration and pH , and *increased* LWCI , MPO activity , interleukin (IL)-1ß , IL-6 and [tumor necrosis factor (TNF)-a] mRNA expression , NF-?B p65 positive staining and p38 activation compared with normal controls ( all P < 0.01 ) . Positive_regulation TNF MAPK8 23188524 2745415 We found that and Akt inhibitors , but not PI3K inhibitor , remarkably *suppressed* ACPA mediated [TNF-a] production . Positive_regulation TNF MAPK8 23354775 2769962 p38a may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , [tumor necrosis factor-a] , interleukin-1ß , and oxidative stress . Positive_regulation TNF MAPK8 23364439 2754529 Conversely , HTS activated p38 mitogen activated protein kinase (MAPK) and enhanced [TNF-a] *activation* of p38 . Positive_regulation TNF MAPK8 23557259 2777810 Inhibition of and CD137 signaling *reduce* dengue virus induced [TNF-a] secretion and apoptosis . Positive_regulation TNF MAPK8 23734186 2796933 Bla g 2 can stimulate up-regulation of inflammatory cytokines including [TNF-alpha] and IL-6 and *activation* of nuclear factor kappa B ( NF-kB/p65 ) , p38 ( p38 ) , ERK , and JNK in cultured fibrocytes . Positive_regulation TNF MAPK8 24089494 2848140 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed [TNF] receptor 1 and *requires* activation of p38 , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation TNF MAPK8 24437486 2922607 After administration of a nonselective ß-adrenergic receptor blocker ( propranolol ) before induction of cerebral ischemic injury , hepatic adrenergic transduction , [TNF-a] expression , ER stress , and the *activation* of the , IKK-ß , and NF-?B pathways , and serine phosphorylation of IRS-1 were all attenuated . Positive_regulation TNF MAPK8 24441870 2922975 On the other hand , [TNF-a] could *induce* Akt and p42/p44 translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation TNF MAPK8 24750790 2936522 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas [TNFalpha] and NO production *required* all three . Positive_regulation TNF MAPK8 7722327 301750 [TNF-alpha] *induces* tyrosine phosphorylation of in adherent human neutrophils . Positive_regulation TNF MAPK8 7722327 301802 These results indicate that [TNF] signaling *involves* activation of . Positive_regulation TNF MAPK8 9006914 410767 [TNFalpha] stimulation of endothelial cells induces transient phosphorylation of both ATF-2 and c-JUN and *induces* marked activation of the c-JUN N-terminal kinase ( ) and p38 but not extracellular signal regulated kinase ( ERK1 ) . Positive_regulation TNF MAPK8 9148963 430057 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Positive_regulation TNF MAPK8 9325311 456834 In trying to understand the mechanism of GPS2 activity , we found that it also suppressed [TNFalpha] *activation* of but not TNFalpha activation of p38 kinase nor phorbol activation of extracellular signal regulated kinase 2 . Positive_regulation TNF MAPK8 9418855 480534 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Positive_regulation TNF MAPK8 9439626 482888 These findings suggest a role for [TNF-alpha] in the regulation of intestinal epithelial cell growth and that the mitogenic effect of TNF-alpha *requires* protein tyrosine phosphorylation and activation . Positive_regulation TNF MAPK8 9551930 499086 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , IL-1beta , and [TNF-alpha] , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation TNF MAPK8 9706151 526180 We hypothesized that hydrogen peroxide ( H2O2 ) induces myocardial dysfunction and cardiomyocyte death via P38 *mediated* myocardial [tumor necrosis factor (TNF)] production . Positive_regulation TNF MAPK8 9730957 530352 However , in contrast to the wild-type endotoxin , it failed to induce significant production of [tumor necrosis factor-alpha] and macrophage inflammatory protein-1alpha by monocytes and did not *induce* the phosphorylation and nuclear translocation of . Positive_regulation TNF MAPK8 9766635 538496 [TNF-alpha] and GM-CSF priming of superoxide release stimulated by N-formyl-methionyl-leucyl-phenylalanine was significantly *attenuated* by the MEK inhibitor , PD098059 , and the p38 inhibitor , SB203580 . Positive_regulation TNF MAPK8 9864164 582568 A selective p38 inhibitor , SB203580 , *blocked* [TNF] -- or ceramide induced CREB phosphorylation , but had no effect on the induction of apoptosis mediated by these agents . Positive_regulation TNF MAPK8 9864164 582649 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Positive_regulation TNF MAPK8 9883899 558201 *Activation* of p42/p44 mitogen activated protein kinases (MAPK) and p38 by [tumor necrosis factor (TNF)] is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation TNF MAPK9 10079106 595516 Specific inhibitors of p38alpha *blocked* LPS induced adhesion , nuclear factor-kappa B (NF-kappaB) activation , and synthesis of [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF MAPK9 10079106 595570 Inhibition of p38alpha *resulted* in a transient decrease in [TNF-alpha] mRNA accumulation but persistent loss of TNF-alpha synthesis . Positive_regulation TNF MAPK9 10079106 595583 These findings support a pathway by which LPS stimulation of neutrophils results in activation of MKK3 , which in turn activates p38alpha , ultimately regulating adhesion , NF-kappaB activation , *enhanced* gene expression of [TNF-alpha] , and regulation of TNF-alpha synthesis . Positive_regulation TNF MAPK9 10210635 607646 ( 1 ) The human heart produces TNF-alpha after I/R , ( 2 ) p38 *mediates* myocardial I/R induced [TNF-alpha] production , ( 3 ) p38 MAPK inhibition limits functional impairment after I/R , and ( 4 ) inhibition of ischemia induced TNF-alpha production may represent a potent therapeutic strategy for improving myocardial function after angioplasty , coronary bypass , or heart transplantation . Positive_regulation TNF MAPK9 10329111 613034 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Positive_regulation TNF MAPK9 10521481 653045 Engagement of tumor necrosis factor (TNF) receptor 1 leads to ATF-2- and p38 *dependent* [TNF-alpha] gene expression . Positive_regulation TNF MAPK9 10521481 653103 The study presented here shows that autoregulation of [TNF-alpha] gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) *requires* p38 activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element . Positive_regulation TNF MAPK9 10586056 571709 Ligation of microglial CD40 results in p44/42 *dependent* [TNF-alpha] production that is opposed by TGF-beta 1 and IL-10 . Positive_regulation TNF MAPK9 10586056 571763 Inhibition of the upstream activator of p44/42 , mitogen activated protein/extracellular signal related kinase kinase 1/2 , with PD98059 , decreases phosphorylation of p44/42 MAPK and significantly *reduces* [TNF-alpha] release following ligation of microglial CD40 . Positive_regulation TNF MAPK9 10601128 574182 [Tumor necrosis factor-alpha (TNF-alpha)] alone can *induce* extracellular signal regulated kinase ( ERK ) , p38 , and c-Jun N-terminal kinase activity in a rapid and transient manner , whereas interferon-gamma (IFN-gamma) can induce only ERK . Positive_regulation TNF MAPK9 10620700 657676 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Positive_regulation TNF MAPK9 10653605 663301 These results suggest that ( 1 ) while PTK and are *essential* for the production of [TNFalpha] , they are not necessary for the induction of MnSOD by LPS , and ( 2 ) while activation of NFkappaB alone is insufficient for the induction of TNFalpha mRNA by LPS , it is necessary for the induction of TNFalpha as well as MnSOD mRNAs . Positive_regulation TNF MAPK9 10655266 663533 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Positive_regulation TNF MAPK9 10657669 664196 Systemic inhibition of p38 *resulted* in significant decreases in the release of [TNF-alpha] and neutrophil accumulation in the airspaces following intratracheal administration of LPS . Positive_regulation TNF MAPK9 10669634 665801 In this study , we show that [TNF-alpha] *induces* a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs . Positive_regulation TNF MAPK9 10783388 707829 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Positive_regulation TNF MAPK9 10857765 704540 These findings indicate that beta2-adrenoceptor stimulation during an LPS challenge prevented [TNF-alpha] production as a *consequence* of inhibition and enhanced cAMP generation , which at a later stage was associated with an anti-inflammatory effect of IL-6 . Positive_regulation TNF MAPK9 11076936 786259 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Positive_regulation TNF MAPK9 11153597 761146 SB 203580 is a pyridinyl imidazole compound which *inhibits* the release of pro-inflammatory cytokines , such as [tumour necrosis factor-alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) , in vitro and in vivo by inhibiting p38 . Positive_regulation TNF MAPK9 11221891 787438 Kinase suppressor of ras is necessary for [tumor necrosis factor] alpha *activation* of extracellular signal regulated in intestinal epithelial cells . Positive_regulation TNF MAPK9 11221891 787464 activity is *essential* for [tumor necrosis factor (TNF)] alpha receptor 1 regulation of intestinal epithelial cell proliferation . Positive_regulation TNF MAPK9 11278471 802566 [Tumor necrosis factor-alpha] induction of endothelial ephrin A1 expression is *mediated* by a p38 and SAPK/JNK dependent but nuclear factor-kappa B-independent mechanism . Positive_regulation TNF MAPK9 11299196 803172 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Positive_regulation TNF MAPK9 11443053 833733 Finally , PD-98059 , a p42/44 pathway inhibitor , *blocked* [TNF-alpha] upregulation by eNOS ( P = 0.02 ) . Positive_regulation TNF MAPK9 11443055 833747 p38 *mediates* renal tubular cell [TNF-alpha] production and TNF-alpha dependent apoptosis during simulated ischemia . Positive_regulation TNF MAPK9 11443055 833787 Furthermore , 60 min of ischemia induced renal tubular cell apoptosis at all substrate replacement time points examined , with peak apoptotic cell death occurring after either 24 or 48 h . p38 MAPK inhibition abolished [TNF-alpha] mRNA production and TNF-alpha bioactivity , and both p38 inhibition and TNF-alpha neutralization ( anti-porcine TNF-alpha antibody ) *prevented* apoptosis after 60 min of SI . Positive_regulation TNF MAPK9 11443055 833800 These results constitute the initial demonstration that 1 ) renal tubular cells produce TNF-alpha mRNA and biologically active [TNF-alpha] and undergo apoptosis in response to SI , and 2 ) p38 *mediates* renal tubular cell TNF-alpha production and TNF-alpha dependent apoptosis after SI . Positive_regulation TNF MAPK9 11675371 873183 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Positive_regulation TNF MAPK9 11699878 878397 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Positive_regulation TNF MAPK9 11715476 581278 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Positive_regulation TNF MAPK9 11728947 884764 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Positive_regulation TNF MAPK9 11815388 907601 ( ERK ) blockade ( PD-98059 ) *attenuated* [TNF-alpha] secretion , an effect synergistically amplified in the presence of SB-203580 . Positive_regulation TNF MAPK9 11994432 938944 Evidence for a dual mechanism for IL-10 suppression of [TNF-alpha] production that does not *involve* inhibition of p38 or NF-kappa B in primary human macrophages . Positive_regulation TNF MAPK9 12130576 966556 Phosphorylation of p38 was *induced* by RANKL , IL-1 , [TNFalpha] , and LPS in osteoclast precursors but not in osteoclasts . Positive_regulation TNF MAPK9 12391245 1007390 Release of [TNF-alpha] , macrophage-inflammatory protein (MIP)-2 ( MIP-1beta ) , and IL-8 by LPS stimulated neutrophils was also *reduced* by poststimulation p38 inhibition . Positive_regulation TNF MAPK9 12392277 1007669 Inhibition of p38 with SB203580 *inhibited* the production of [TNF-alpha] and IL-10 by LPS stimulated KCs , whereas blockade of ERK1/2 with PD98059 could reduce TNF-alpha production , but did not affect IL-10 production . Positive_regulation TNF MAPK9 12393915 1025408 This model probiotic also inhibits *activation* of the pro-apoptotic by [tumor necrosis factor] , interleukin-1alpha , or gamma-interferon . Positive_regulation TNF MAPK9 12438325 1016571 The activation of protein tyrosine kinases (PTK) and the serine/threonine kinases p38 and ERK was apparently *required* for MTSA-10 induction of [TNF-alpha] and NO release , as revealed by specific kinase inhibitors . Positive_regulation TNF MAPK9 12506117 1056935 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Positive_regulation TNF MAPK9 12631113 1067658 The present data indicate that [TNF-alpha] *activation* of PKCzeta/iota , p42/44 , c-Jun/AP-1 , and p65/NF-kappaB are involved in TNF-alpha stimulated MC fractalkine expression , with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro . Positive_regulation TNF MAPK9 12637577 1099261 Here we show unequivocally that the production of interleukin (IL)-1beta , IL-6 , IL-10 , and [tumor necrosis factor alpha (TNFalpha)] *requires* p38 activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580 . Positive_regulation TNF MAPK9 12694807 1080904 [TNF-alpha] *induced* the phosphorylation of p44/p42 and p38 MAP kinase . Positive_regulation TNF MAPK9 12881424 1116125 Importantly , [TNF] does not *induce* ROS accumulation or prolonged activation in wild-type MEFs , indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death Positive_regulation TNF MAPK9 12969251 1139158 Inhibition of the MAP-kinase-kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) pathway , but not that of ( MAPK-p38 ) , *reduced* NO , [TNF-alpha] and IL-6 significantly , suggesting that simultaneous activation of the first two pathways is necessary for the AGE induced induction of these pro-inflammatory stimuli . Positive_regulation TNF MAPK9 14654378 1176821 These findings suggest that the pre-ischemic *activation* of by [TNF] does not contribute to cardioprotection afforded by this agent . Positive_regulation TNF MAPK9 14980980 1220300 The selective p38 inhibitor , SB203580 , *inhibited* the promoter activities of iNOS and COX-2 rather than that of [TNF-alpha] . Positive_regulation TNF MAPK9 15027449 1222858 Apoptosis caused by chronic ethanol treatment may be due to ethanol potentiation of [TNF] *induced* activation of p38 . Positive_regulation TNF MAPK9 15100302 1239726 Previous studies have shown the mitogen activated protein kinases ( MAPKs ) to be activated in macrophages upon infection with Mycobacterium , and that expression of [TNF-alpha] and inducible NO synthase by infected macrophages was *dependent* on activation . Positive_regulation TNF MAPK9 15139014 1246951 The increase in [TNF-alpha] release by Glu or KA *required* extracellular Na+ and Ca2+ ions but not , suggesting the effects of PEPA and CTZ were not due to the inhibition of MAPK . Positive_regulation TNF MAPK9 15233873 1269384 A. semen also inhibited the expression of [TNF-alpha] and the *activation* of , ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells , as indicated by the suppression of the activating phosphorylation of ERK1/2 . Positive_regulation TNF MAPK9 15248214 1271215 Specific inhibitors of MAPK/ERK-1/2 kinases and p38 significantly *reduced* the production of [TNFalpha] and IL-1beta by rsCD154 plus IFNgamma stimulated CD14+ synovial cells , and also inhibited production of these cytokines by freshly isolated synovial cells from RA patients . Positive_regulation TNF MAPK9 15302094 1283844 Selective p42/44 inhibitor could *reduce* the Pb- and LPS triggered [TNF-alpha] expression in U-373MG cells . Positive_regulation TNF MAPK9 15557189 1340417 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Positive_regulation TNF MAPK9 15557189 1340443 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Positive_regulation TNF MAPK9 15592496 1375222 Tenascin-W is found in malignant mammary tumors , promotes alpha8 integrin dependent motility and *requires* activity for BMP-2 and [TNF-alpha] induced expression in vitro . Positive_regulation TNF MAPK9 15614136 1357469 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Positive_regulation TNF MAPK9 15701814 1416534 p38 activation *leads* to increased production of [TNF-alpha] in ischemic injury and in macrophages . Positive_regulation TNF MAPK9 15701814 1416561 Inhibition of p38 activation *led* to inhibition of [TNF-alpha] production . Positive_regulation TNF MAPK9 15703956 1497461 *Activation* of p38 and phosphatidylinositol 3-kinase (PI3K) by [TNF-alpha] was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation TNF MAPK9 15833800 1425445 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Positive_regulation TNF MAPK9 15867183 1404208 In cultured cardiac myocytes , specific activation of stress activated , p38 , by upstream activator MKK6bE *led* to significant induction of [tumor necrosis factor-alpha] and interleukin-6 secretion , whereas treating cells with a selective p38 inhibitor ( SB239068 ) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation . Positive_regulation TNF MAPK9 15893422 1419738 We also investigated whether specific inhibition of p38 and Erk1/2 would *inhibit* [TNF-alpha] and IL-6 production and thus astrocyte apoptosis , and proliferation , respectively . Positive_regulation TNF MAPK9 15925386 1440379 Our observations show that calcium , activation , HIF-1alpha , and NF-kappaB are *necessary* for ethanol induced [TNF-alpha] and TGF-beta1 expression . Positive_regulation TNF MAPK9 16051807 1438617 Specific inhibitors of p38 significantly *reduced* the H5N1/97 induced [TNF-alpha] expression in macrophages . Positive_regulation TNF MAPK9 16081599 1460343 These results indicate that gp120 elicited [TNF-alpha] production by macrophages *involves* chemokine receptor mediated PI-3K and activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and ERK-1/2 independently regulate TNF-alpha production . Positive_regulation TNF MAPK9 16271232 1479211 Similarly , the increased gene expression of proinflammatory cytokines [TNF-alpha] and IL-1beta in gastric mucosa induced by WIR stress were significantly *diminished* by p38 inhibition . Positive_regulation TNF MAPK9 16275991 1480276 Angiotensin II , [tumor necrosis factor-alpha] , or epidermal growth factor *induced* phosphorylation in PrSC cells , and this phosphorylation was inhibited by ARB . Positive_regulation TNF MAPK9 16291729 1526061 *Activation* of and Akt by anti-HER2/neu [ScFv-TNF-alpha] inhibited the apoptosis of SKBR3 cells induced by actinomycin D. Remarkably , anti-HER2/neu ScFv-TNF-alpha facilitated the repair of injured epithelia . Positive_regulation TNF MAPK9 16403817 1540134 The [TNF] + dex stimulated increase in leptin was associated with an increase in p38 MAPK activity and was totally *blocked* by p38 inhibitors . Positive_regulation TNF MAPK9 16438946 1495435 Although gAd partially increased cAMP concentration and PKA activity , it directly reduced leptin induced ERK1/2 and p38 phosphorylation thus *inhibiting* [TNF-alpha] production . Positive_regulation TNF MAPK9 16480618 1496073 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Positive_regulation TNF MAPK9 16480618 1496112 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Positive_regulation TNF MAPK9 16517732 1530911 Furthermore , using the p38 inhibitor SB203580 , we show that the TLR4 induced production of [TNF] , but not IL-6 , *requires* the activity of p38 . Positive_regulation TNF MAPK9 16573652 1556130 HA-mediated [TNF-alpha] production *required* p38 , extracellular regulated kinase and c-Jun N-terminal kinase phosphorylation in both cell types . Positive_regulation TNF MAPK9 16581537 1543744 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Positive_regulation TNF MAPK9 16596287 1544890 These results collectively reveal that AV-ext *inhibits* [TNF-alpha] release from macrophages by suppressing and NF-kappaB signaling pathways and suggest that AV-ext may be beneficial for the treatment of endotoxin shock or sepsis . Positive_regulation TNF MAPK9 16771851 1572713 this process then leads to modulation of p38 *dependent* IL-8 and [TNF-alpha] release from the epithelium . Positive_regulation TNF MAPK9 16781693 1585609 Chitin particles , in contrast , failed to induce detectable levels of IL-10 , although the production of high levels of PGE ( 2 ) and [TNF-alpha] and the *activation* of 's are potentially positive signals for IL-10 production . Positive_regulation TNF MAPK9 16867160 1592842 Further , the activation of p38 and extracellular signal regulated kinase was *required* for the induction of [TNF-alpha] and IL-6 by MTB12 , as well as by the 30-kDa Ag . Positive_regulation TNF MAPK9 17032936 1692730 The stimulation of [TNF-alpha] production was *dependent* on cisplatin induced activation of p38 and was associated with phosphorylation of the translation initiation factor eIF4E and its upstream kinase Mnk1 . Positive_regulation TNF MAPK9 17032936 1692743 Inhibition of p38 and , to a lesser extent , ERK , *reduced* cisplatin+endotoxin stimulated [TNF-alpha] production and phosphorylation of Mnk1 and eIF4E . Positive_regulation TNF MAPK9 17074860 1675551 B. burgdorferi induced [TNF-alpha] production is also *dependent* on the activation of p38 . Positive_regulation TNF MAPK9 17117477 1677363 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Positive_regulation TNF MAPK9 17126905 1686523 Differential regulation of [TNFalpha] and GM-CSF *induced* activation of P38 in neutrophils and eosinophils . Positive_regulation TNF MAPK9 17131360 1700737 In addition , we recently found that p38 *mediates* [TNF-alpha] upregulation of atrogin-1/MAFbx expression , suggesting that multiple signaling pathways mediate muscle wasting in inflammatory diseases . Positive_regulation TNF MAPK9 17138860 1653566 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Positive_regulation TNF MAPK9 17172975 1679380 This was followed by lipid raft mobilization of SH related complex homology 2 domain containing inositol-5-phosphate ( SHIP ) , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK9 17172975 1679406 Pretreatment with alpha-tocopherol succinate did not affect mobilization of TLR4 or heat shock protein 70 , but did result in attenuated mobilization of SHIP , *activation* of the , and production of [TNF-alpha] . Positive_regulation TNF MAPK9 17202326 1680808 Augmented lipopolysaccharide induced [TNF-alpha] production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK9 17202326 1680834 In this study , we show that augmented LPS induced [TNF-alpha] production by resident peritoneal macrophages ( PerMphi ) in type 2 diabetic ( db/db ) mice is dependent on elevated glucose and *requires* p38 . Positive_regulation TNF MAPK9 17395780 1766155 Here we demonstrate that Rab7b can negatively regulate lipopolysaccharide (LPS) induced production of [tumor necrosis factor (TNF)-alpha] , IL-6 , nitric oxide , and IFN-beta , and potentiate LPS induced *activation* of , nuclear factor kappaB , and IFN regulatory factor 3 signaling pathways in macrophages by promoting the degradation of TLR4 . Positive_regulation TNF MAPK9 17438131 1742749 The alpha-4 dominant negative domain ( DND ) ( residues 220 to 340 ) associated with MEK3 , but not PP2A , and its overexpression sensitized cells to *activation* of p38 by [TNF-alpha] and interleukin-1beta , but not by ansiomycin or sorbitol . Positive_regulation TNF MAPK9 17553937 1792001 Twenty-four hours thereafter , splenic macrophages were isolated , and their IL-6 and [TNF-alpha] production and *activation* of and NF-kappaB were measured . Positive_regulation TNF MAPK9 17607712 1798181 Although [TNF] *induced* the activation of p38 , JNK , ERK and PI-3K signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation TNF MAPK9 17902045 1835082 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Positive_regulation TNF MAPK9 17934341 1813489 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Positive_regulation TNF MAPK9 17940160 1888989 Conversely , Ser phosphorylation of IRS-2 mediated by [TNF-alpha] *activation* of was the mechanism found in brown adipocytes . Positive_regulation TNF MAPK9 17964662 1831055 Taken together , these results suggest that linomide *inhibits* [TNF-alpha] production by suppressing the activation of NF-kappaB and , which might , at least in part , contribute to the beneficial effects of linomide in the treatment of autoimmune diseases . Positive_regulation TNF MAPK9 17994109 1851150 [TNF-alpha] triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* Ras , p38 , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation TNF MAPK9 18227157 1884339 It was shown that these three proteins could ( i ) induce expression of [tumor necrosis factor alpha (TNF-alpha)] and tissue factor and ( ii ) *induce* phosphorylation of p44/42 and activation of early growth response factor 1 (Egr-1) . Positive_regulation TNF MAPK9 18296636 1878866 Whereas the induction of [TNFalpha] , IL-1beta , and IL-6 by IL-32 is *mediated* by , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic , caspase-3 dependent mechanisms . Positive_regulation TNF MAPK9 18303184 1873529 Inhibition of p38 activation selectively *blocked* DNCB induced [TNF-alpha] release , but not NiSO ( 4 ) -induced release . Positive_regulation TNF MAPK9 18314537 1919439 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Positive_regulation TNF MAPK9 18390808 1925672 We tested the hypothesis that p38 activation is *necessary* for [TNF-alpha] production , neutrophil activation , and subsequent liver injury . Positive_regulation TNF MAPK9 18622138 1984364 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Positive_regulation TNF MAPK9 18675993 2011335 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Positive_regulation TNF MAPK9 19002259 1991237 Peptidoglycan stimulated monocyte p38 and p38 activity was *required* for [TNFalpha] production by the cells . Positive_regulation TNF MAPK9 19040616 2017413 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Positive_regulation TNF MAPK9 19043204 1998826 Moreover , [TNF-alpha] production was *prevented* by NF-kappaB and inhibitors . Positive_regulation TNF MAPK9 19052649 1999792 This was followed by p38 activation and *resulted* in a time dependent increase in [TNF-alpha] production . Positive_regulation TNF MAPK9 19250666 2055383 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Positive_regulation TNF MAPK9 19267548 2045608 Since activated p38 *mediates* [TNF-alpha] production , we examined the effect of radiation on LPS induced activation of p38 MAPK and TNF-alpha production . Positive_regulation TNF MAPK9 19287189 2046610 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Positive_regulation TNF MAPK9 19351958 2088785 Specific inhibitors of p38 and glycogen synthase kinase 3 *suppressed* [TNF-alpha] production and maturation of fucoidan treated PBDCs . Positive_regulation TNF MAPK9 19427347 2106788 [TNF-alpha] *induced* the phosphorylation of p38 , stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , and p44/p42 MAP kinase . Positive_regulation TNF MAPK9 19477265 2107666 These results show that chronic ethanol feeding enhances Fas induced liver injury by a mechanism associated with induction of CYP2E1 , elevated serum [TNF-alpha] levels , and *activation* of . Positive_regulation TNF MAPK9 19493203 2091432 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Positive_regulation TNF MAPK9 19493203 2091458 In conclusion , our data indicate that signaling is *required* to induce maximal [TNF-alpha] production in macrophages during Orientia infection . Positive_regulation TNF MAPK9 19751557 2135282 p38MAPK 's phosphorylation is important in pathogenesis of MODS , and phosphorylation of can *enhance* TNF-alpha mRNA transcription and secretion of [TNF-alpha] from peripheral blood mononuclear cells , which is the mechanism of increased TNF-alpha in MODS . Positive_regulation TNF MAPK9 20010392 2175037 Because p38 ( p38 ) *upregulates* [TNF-alpha] expression and may play a crucial role in pain sensation , we investigated the effect of one injection of inhibitor on expression of the pain related neuropeptide calcitonin gene related peptide (CGRP) . Positive_regulation TNF MAPK9 20068037 2235137 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Positive_regulation TNF MAPK9 20083499 2380900 For the first time , we show that , in fish macrophages , [TNF-a] is processed by TACE-like activity and this cleavage is *dependent* upon the activation of ERK , and JNK signaling pathways by LPS . Positive_regulation TNF MAPK9 20499049 2276366 Expression of [TNF-alpha] and IL-6 in HMC-1 cells treated with bisphenol A is *attenuated* by plant originating glycoprotein ( 75 kDa ) by blocking p38 . Positive_regulation TNF MAPK9 20589681 2334370 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Positive_regulation TNF MAPK9 20646342 2292570 [TNF-alpha] *induced* a significant increase in p38 phosphorylation . Positive_regulation TNF MAPK9 20868379 2337175 [TNF-a] expression was *mediated* in a time dependent manner by p38 , activation of which is under the control of MKP1 . Positive_regulation TNF MAPK9 21208554 2374424 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Positive_regulation TNF MAPK9 21402598 2426934 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Positive_regulation TNF MAPK9 21545687 2554371 [Tumour necrosis factor-a (TNF-a)] significantly *induced* phosphorylation of p38 , ERK , Akt and production of IL-8 from HCC cells , which were prevented by SB203580 ( p38 MAPK inhibitor ) , PD98059 ( ERK inhibitor ) , LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor ) . Positive_regulation TNF MAPK9 21642540 2446241 Pretreatment with TAT-SNAP-23 inhibited the increase in plasma membrane expression of gp91(phox) in TNF-a primed neutrophils , whereas [TNF-a] *activation* of ERK1/2 and p38 was not affected . Positive_regulation TNF MAPK9 21849907 2495998 All 3 inhibitors *suppressed* LPS induced [TNF-a] and I-309 expression in human primary monocytes . Positive_regulation TNF MAPK9 22002864 2526308 In this study , we found that inhibition of p38 with SB-203580 ( SB ) *reduced* H ( 2 ) O ( 2 ) -stimulated secretion of TNF-a , whereas pre-activation of p38 MAPK with sodium arsenite ( SA ) enhanced H ( 2 ) O ( 2 ) -stimulated secretion of [TNF-a] . Positive_regulation TNF MAPK9 22343222 2617767 Using immunohistological techniques , we showed a higher epithelial expression of [TNF-a] , IL-1ß , and IL-6 , as well as an *activation* of NF-?B and activator signaling pathways in the respiratory tract of smoking patients , compared with the normal ciliated epithelium of nonsmoking patients . Positive_regulation TNF MAPK9 22385244 2566479 The use of selective inhibitors of signalling pathways revealed that induction of TG2 by IFN-? was mediated by phosphoinositide 3-kinase (PI3K) , while c-Jun N-terminal kinase (JNK) and p38 were *required* for [TNF-a] activation . Positive_regulation TNF MAPK9 22744777 2853453 After LPS administration , all animals displayed increased arterial carbon dioxide partial pressure ( PaCO2 ) and decreased arterial oxygen partial pressure ( PaO2 ) , arterial oxygen saturation ( SO2 ) , HCO3 ( - ) concentration and pH , and *increased* LWCI , MPO activity , interleukin (IL)-1ß , IL-6 and [tumor necrosis factor (TNF)-a] mRNA expression , NF-?B p65 positive staining and p38 activation compared with normal controls ( all P < 0.01 ) . Positive_regulation TNF MAPK9 23188524 2745416 We found that and Akt inhibitors , but not PI3K inhibitor , remarkably *suppressed* ACPA mediated [TNF-a] production . Positive_regulation TNF MAPK9 23354775 2769963 p38a may be essential in the up-regulation of proinflammatory cytokines and can be *activated* by transforming growth factor ß , [tumor necrosis factor-a] , interleukin-1ß , and oxidative stress . Positive_regulation TNF MAPK9 23364439 2754530 Conversely , HTS activated p38 mitogen activated protein kinase (MAPK) and enhanced [TNF-a] *activation* of p38 . Positive_regulation TNF MAPK9 23557259 2777811 Inhibition of and CD137 signaling *reduce* dengue virus induced [TNF-a] secretion and apoptosis . Positive_regulation TNF MAPK9 23734186 2796934 Bla g 2 can stimulate up-regulation of inflammatory cytokines including [TNF-alpha] and IL-6 and *activation* of nuclear factor kappa B ( NF-kB/p65 ) , p38 ( p38 ) , ERK , and JNK in cultured fibrocytes . Positive_regulation TNF MAPK9 24089494 2848141 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed [TNF] receptor 1 and *requires* activation of p38 , phosphatidylinositol 3-kinase , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation TNF MAPK9 24441870 2922976 On the other hand , [TNF-a] could *induce* Akt and p42/p44 translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation TNF MAPK9 24750790 2936523 Specifically , inhibition of MAPK activation with specific inhibitors revealed that IL-12 production required p38 MAPK activation , whereas [TNFalpha] and NO production *required* all three . Positive_regulation TNF MAPK9 7722327 301751 [TNF-alpha] *induces* tyrosine phosphorylation of in adherent human neutrophils . Positive_regulation TNF MAPK9 7722327 301803 These results indicate that [TNF] signaling *involves* activation of . Positive_regulation TNF MAPK9 9148963 430058 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Positive_regulation TNF MAPK9 9418855 480535 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Positive_regulation TNF MAPK9 9439626 482889 These findings suggest a role for [TNF-alpha] in the regulation of intestinal epithelial cell growth and that the mitogenic effect of TNF-alpha *requires* protein tyrosine phosphorylation and activation . Positive_regulation TNF MAPK9 9551930 499087 The results in this paper indicate that inhibition of p38 potently *inhibited* the production of IL-10 , IL-1beta , and [TNF-alpha] , whereas blockade of the p42/44 MAPK pathway , while partially inhibiting TNF-alpha and IL-1beta production , had no effect on monocyte secretion of IL-10 . Positive_regulation TNF MAPK9 9706151 526181 We hypothesized that hydrogen peroxide ( H2O2 ) induces myocardial dysfunction and cardiomyocyte death via P38 *mediated* myocardial [tumor necrosis factor (TNF)] production . Positive_regulation TNF MAPK9 9730957 530353 However , in contrast to the wild-type endotoxin , it failed to induce significant production of [tumor necrosis factor-alpha] and macrophage inflammatory protein-1alpha by monocytes and did not *induce* the phosphorylation and nuclear translocation of . Positive_regulation TNF MAPK9 9766635 538497 [TNF-alpha] and GM-CSF priming of superoxide release stimulated by N-formyl-methionyl-leucyl-phenylalanine was significantly *attenuated* by the MEK inhibitor , PD098059 , and the p38 inhibitor , SB203580 . Positive_regulation TNF MAPK9 9864164 582569 A selective p38 inhibitor , SB203580 , *blocked* [TNF] -- or ceramide induced CREB phosphorylation , but had no effect on the induction of apoptosis mediated by these agents . Positive_regulation TNF MAPK9 9864164 582650 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Positive_regulation TNF MAPK9 9883899 558202 *Activation* of p42/p44 and p38 MAPK by [tumor necrosis factor (TNF)] is mediated through the death domain of the 55-kDa TNF receptor . Positive_regulation TNF MAPKAP1 17368935 1748307 Luteolin ( 1 and 10microM ) decreased the *induced* production of NO , PGE ( 2 ) , [TNF-alpha] , and IL-6 in osteoblasts . Positive_regulation TNF MAPKAP1 19250650 2051027 or ONOO- *increased* nitrosylation of MMP1/MMP13 and transactivation of the MMP1 , MMP13 , and [TNFalpha] promoters . Positive_regulation TNF MAPKAPK2 14688255 1211472 is *required* for [tumor necrosis factor] synthesis . Positive_regulation TNF MAPKAPK2 16620770 1556715 ( MAPKAPK2 ) *regulates* the synthesis of [tumor necrosis factor] and other cytokines and is a potential drug target for inflammatory diseases . Positive_regulation TNF MAPKAPK2 17485113 1744267 Distinct *role* of in the regulation of [TNF] gene expression by Toll-like receptor 7 and 9 ligands . Positive_regulation TNF MAPKAPK2 18486623 1927778 [TNF] stimulation *induced* p38 MAPK dependent phosphorylation of and HSP27 . Positive_regulation TNF MAPKAPK2 18620516 1936182 Disruption of *leads* to a reduction in [TNF-alpha] production . Positive_regulation TNF MAPKAPK2 19359247 2081240 In this study , we investigated the *role* of in the regulation of [tumor necrosis factor-alpha (TNF-alpha)] and interleukin (IL)-12 , two of the major inflammatory cytokines produced by macrophages stimulated with GPIs . Positive_regulation TNF MAPKAPK2 19359247 2081247 We show that differentially *regulates* the GPI induced production of [TNF-alpha] and IL-12 . Positive_regulation TNF MARCO 16525990 1541880 and SR-A contributed independently to NM binding , correlating with their expression levels in different cell populations , but neither of these two molecules was *required* for release of [TNF-alpha] and nitric oxide . Positive_regulation TNF MAST1 12370127 995533 cell *derived* IL-6 and [TNF-alpha] , followed by SP-stimulated degranulation , have the potential to induce nerve growth factor expression by sebaceous cells which results in the promotion of innervation and in the expression of E-selectin , respectively . Positive_regulation TNF MAST2 12370127 995534 cell *derived* IL-6 and [TNF-alpha] , followed by SP-stimulated degranulation , have the potential to induce nerve growth factor expression by sebaceous cells which results in the promotion of innervation and in the expression of E-selectin , respectively . Positive_regulation TNF MAST3 12370127 995535 cell *derived* IL-6 and [TNF-alpha] , followed by SP-stimulated degranulation , have the potential to induce nerve growth factor expression by sebaceous cells which results in the promotion of innervation and in the expression of E-selectin , respectively . Positive_regulation TNF MAST4 12370127 995536 cell *derived* IL-6 and [TNF-alpha] , followed by SP-stimulated degranulation , have the potential to induce nerve growth factor expression by sebaceous cells which results in the promotion of innervation and in the expression of E-selectin , respectively . Positive_regulation TNF MATN1 24055693 2888230 We found that the quantity of IL-6 , but not [TNF-a] or CHI3L1 , *induced* by was significantly correlated with plasma IL-6 , BMI , waist/hip circumferences , fasting plasma insulin , and insulin resistance . Positive_regulation TNF MATN1 8194697 258994 Peripheral blood mononuclear cells ( PBMC ) from infants with CMA were cultured in the *presence* of , and the release of [tumor necrosis factor alpha (TNF-alpha)] , interferon gamma (IFN-gamma) , and interleukin 4 and 6 was measured . Positive_regulation TNF MBL2 10898508 712101 Studying the functional consequences of the interaction , we found that the release of [TNF-alpha] from Mphi is *induced* by C1q but not by . Positive_regulation TNF MBP 10229113 610976 Ibudilast mildly suppressed *induced* proliferation of T cells in regional lymph nodes , the secretion of interferon-gamma from T cells activated by MBP in CFA , and the secretion of [tumor necrosis factor-alpha] from macrophages . Positive_regulation TNF MBP 18397264 1958066 The *induced* a dose dependent release of interferon-gamma (IFN-gamma) , [tumour necrosis factor-alpha (TNF-alpha)] and interleukin-10 (IL-10) by patient derived MNCs . Positive_regulation TNF MBP 7544384 318278 Mechanisms by which IFN-tau may prevent EAE include reduced proliferation in *response* to the autoantigen and reduced [TNF-alpha] production . Positive_regulation TNF MBP 8624683 354928 The *induced* upregulation of [TNF-alpha] and LT was major histocompatibility complex ( MHC) class II molecule dependent . Positive_regulation TNF MBP 8872905 389715 Stimulation of cells from MBP73-84 : 1028 coimmunized protected rats proliferate and secrete interferon-gamma (IFN-gamma) and [tumor necrosis factor-alpha (TNF-alpha)] in vitro in *response* to . Positive_regulation TNF MBP 9688330 521947 There was no correlation of *mediated* lysis of astrocytes with TCR-Vbeta usage , HLA-restriction and the production of [tumor-necrosis-factor-alpha (TNF-alpha)] , lymphotoxin ( LT ) and interferon-gamma (IFN-gamma) . Positive_regulation TNF MBS1 23122182 2707109 MBS cytotoxicity and *induced* anticancer cytokines , [TNF-a] and IFN-ß from cancer cells , and immunological cytokines , IL-4 , IFN-? , and IL-10 from peripheral mononuclear cells ( PMNC ) were assessed by MTS and ELISA assays . Positive_regulation TNF MBTPS1 16936207 1609012 In cultured adipocytes , ceramide , sphingosine , and *induced* gene expression of plasminogen activator inhibitor-1 , [TNF-alpha] , monocyte chemoattractant protein-1 , interleukin-6 , and keratinocyte derived chemokine . Positive_regulation TNF MBTPS1 17306937 1705230 These data show that increases in the intracellular partly *mediate* [TNF-alpha] induction of IL-8 gene expression in H441 lung epithelial cells via ERK and p38 MAPK signaling pathways and increased AP-1 DNA binding . Positive_regulation TNF MBTPS1 19010292 1991483 Interestingly , *potentiated* the LPS induced systemic production of 3 inflammatory cytokines , [TNF-alpha] ( 6-fold ) , KC ( 1.2-fold ) , and IL-6 ( 3-fold ) , without resulting in end-organ dysfunction . Positive_regulation TNF MBTPS1 20577214 2280426 These results also highlight the key *role* of SphK1 and its product in [TNF-alpha] signalling and the canonical NF-kappaB activation pathway important in inflammatory , antiapoptotic and immune processes . Positive_regulation TNF MBTPS1 20624458 2304149 Although our experimental data clearly show the mediatory *role* of sphingosine kinase (SK) derived in the [TNF-alpha] and the LPS induced activation of NF-kB , exogenously added S1P failed to trigger this transcription factor . Positive_regulation TNF MCAT 16181105 1458360 MCT treatment caused infiltration of inflammatory cells , fibrosis of the interstitium , and pulmonary arterial wall thickening with marked elevation of right ventricular ( RV ) pressure , which are characteristics of *induced* PH. Gene expression of [tumor necrosis factor-alpha (TNF-alpha)] as well as DNA binding activity of nuclear factor-kappaB (NF-kappaB) increased at 1 week after MCT treatment , reached a maximum at 2 weeks , and then decreased to the pretreatment level at 3 weeks . Positive_regulation TNF MCAT 17506718 1744705 RA influences production of an important Th1 cytokine , IFN_ , and demonstrated the greatest limitation of *induced* [TNFalpha] . Positive_regulation TNF MCC 11746260 889066 The synthesis of IL-12 , GM-CSF , and [TNF-alpha] by LNCaP cells in *response* to was also determined . Positive_regulation TNF MCC 11746260 889074 Surprisingly , also directly *induced* the synthesis of IL-12 and GM-CSF , but not [TNF-alpha] , by LNCaP cells . Positive_regulation TNF MCOLN1 8867673 344812 In fact , only in the *presence* of , but not in the absence of divalent cations or in the presence of Ca2+ alone , [TNF] increased p58c-fgr and p53/56lyn kinase activities ; Positive_regulation TNF MDK 18275606 1872059 [TNFalpha] also *induced* expression in PC3 cells . Positive_regulation TNF ME1 19584274 2105131 The cytokine [tumor necrosis factor-alpha (TNFalpha)] , localized immunohistochemically to this affected region of the pilosebaceous unit , was specifically *up-regulated* by in skin but not in other tissues examined . Positive_regulation TNF MED1 10625622 658579 NF-kappaB was activated after the stimulation of TRAP , bFGF , and TNF-alpha in electrophoretic mobility shift assay , and E5510 suppressed the NF-kappaB activation *induced* by and bFGF but not the activation by [TNF-alpha] . Positive_regulation TNF MED1 12171446 974210 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED1 14982858 1214524 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED1 17456789 1761126 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED1 18675993 2011416 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED1 3292408 94743 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED1 9288135 452456 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED10 12171446 974205 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED10 14982858 1214520 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED10 17456789 1761120 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED10 18675993 2011412 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED10 3292408 94739 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED10 9288135 452451 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED11 12171446 974208 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED11 14982858 1214523 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED11 17456789 1761123 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED11 18675993 2011415 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED11 3292408 94742 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED11 9288135 452454 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED12 10625622 658572 NF-kappaB was activated after the stimulation of TRAP , bFGF , and TNF-alpha in electrophoretic mobility shift assay , and E5510 suppressed the NF-kappaB activation *induced* by and bFGF but not the activation by [TNF-alpha] . Positive_regulation TNF MED12 14982858 1214495 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED12 18675993 2011387 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED12 3292408 94714 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED13 12171446 974192 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED13 14982858 1214505 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED13 17456789 1761107 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED13 18675993 2011397 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED13 3292408 94724 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED13 9288135 452438 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED13L 12171446 974193 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED13L 14982858 1214506 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED13L 17456789 1761108 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED13L 18675993 2011398 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED13L 3292408 94725 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED13L 9288135 452439 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED14 10625622 658576 NF-kappaB was activated after the stimulation of TRAP , bFGF , and TNF-alpha in electrophoretic mobility shift assay , and E5510 suppressed the NF-kappaB activation *induced* by and bFGF but not the activation by [TNF-alpha] . Positive_regulation TNF MED14 12171446 974197 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED14 14982858 1214510 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED14 17456789 1761112 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED14 18675993 2011402 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED14 3292408 94729 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED14 9288135 452443 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED15 12171446 974186 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED15 14982858 1214496 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED15 17456789 1761101 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED15 18675993 2011388 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED15 3292408 94715 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED15 9288135 452432 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED16 10625622 658573 NF-kappaB was activated after the stimulation of TRAP , bFGF , and TNF-alpha in electrophoretic mobility shift assay , and E5510 suppressed the NF-kappaB activation *induced* by and bFGF but not the activation by [TNF-alpha] . Positive_regulation TNF MED16 12171446 974188 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED16 14982858 1214499 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED16 17456789 1761103 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED16 18675993 2011391 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED16 3292408 94718 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED16 9288135 452434 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED17 10625622 658577 NF-kappaB was activated after the stimulation of TRAP , bFGF , and TNF-alpha in electrophoretic mobility shift assay , and E5510 suppressed the NF-kappaB activation *induced* by and bFGF but not the activation by [TNF-alpha] . Positive_regulation TNF MED17 12171446 974199 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED17 14982858 1214512 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED17 17456789 1761114 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED17 18675993 2011404 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED17 3292408 94731 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED17 9288135 452445 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED18 12171446 974204 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED18 14982858 1214519 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED18 17456789 1761119 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED18 18675993 2011411 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED18 3292408 94738 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED18 9288135 452450 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED19 12171446 974207 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED19 14982858 1214522 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED19 17456789 1761122 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED19 18675993 2011414 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED19 3292408 94741 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED19 9288135 452453 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED20 12171446 974187 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED20 14982858 1214498 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED20 17456789 1761102 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED20 18675993 2011390 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED20 3292408 94717 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED20 9288135 452433 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED21 12171446 974184 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED21 14982858 1214493 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED21 17456789 1761099 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED21 18675993 2011385 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED21 3292408 94712 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED21 9288135 452430 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED22 12171446 974185 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED22 14982858 1214494 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED22 17456789 1761100 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED22 18675993 2011386 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED22 3292408 94713 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED22 9288135 452431 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED23 12171446 974198 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED23 14982858 1214511 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED23 17456789 1761113 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED23 18675993 2011403 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED23 3292408 94730 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED23 9288135 452444 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED24 10625622 658574 NF-kappaB was activated after the stimulation of TRAP , bFGF , and TNF-alpha in electrophoretic mobility shift assay , and E5510 suppressed the NF-kappaB activation *induced* by and bFGF but not the activation by [TNF-alpha] . Positive_regulation TNF MED24 12171446 974194 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED24 14982858 1214507 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED24 17456789 1761109 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED24 18675993 2011399 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED24 3292408 94726 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED24 9288135 452440 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED25 12171446 974206 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED25 14982858 1214521 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED25 17456789 1761121 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED25 18675993 2011413 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED25 3292408 94740 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED25 9288135 452452 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED26 12171446 974200 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED26 14982858 1214513 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED26 17456789 1761115 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED26 18675993 2011405 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED26 3292408 94732 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED26 9288135 452446 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED27 12171446 974201 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED27 14982858 1214514 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED27 17456789 1761116 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED27 18675993 2011406 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED27 3292408 94733 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED27 9288135 452447 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED28 14982858 1214517 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED28 18675993 2011409 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED28 3292408 94736 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED29 12171446 974196 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED29 14982858 1214509 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED29 17456789 1761111 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED29 18675993 2011401 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED29 3292408 94728 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED29 9288135 452442 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED30 12171446 974195 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED30 14982858 1214508 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED30 17456789 1761110 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED30 18675993 2011400 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED30 3292408 94727 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED30 9288135 452441 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED31 12171446 974203 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED31 14982858 1214516 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED31 17456789 1761118 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED31 18675993 2011408 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED31 3292408 94735 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED31 9288135 452449 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED4 12171446 974189 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED4 14982858 1214501 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED4 17456789 1761104 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED4 18675993 2011393 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED4 3292408 94720 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED4 9288135 452435 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED6 12171446 974190 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED6 14982858 1214503 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED6 17456789 1761105 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED6 18675993 2011395 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED6 3292408 94722 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED6 9288135 452436 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED7 12171446 974202 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED7 14982858 1214515 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED7 17456789 1761117 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED7 18675993 2011407 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED7 3292408 94734 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED7 9288135 452448 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED8 12171446 974191 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF MED8 14982858 1214504 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED8 17456789 1761106 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF MED8 18675993 2011396 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED8 3292408 94723 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MED8 9288135 452437 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF MED9 14982858 1214518 Secretion of [tumor necrosis factor-alpha] from human placental tissues *induced* by hypoxia-reoxygenation causes endothelial cell activation in vitro : a potential of the inflammatory response in preeclampsia . Positive_regulation TNF MED9 18675993 2011410 P38 is a critical of BLP *induced* [TNF-alpha] release and NFkappaB activation , whereas PKC is only partially responsible for its response . Positive_regulation TNF MED9 3292408 94737 Since heat-stable antigens are present in the circulation of patients with malaria , they may *induced* the secretion of [TNF] , a of endotoxic shock , which could contribute to the pathology of the disease . Positive_regulation TNF MEF2C 14515274 1147105 *regulates* c-Jun but not [TNF-alpha] gene expression in stimulated mast cells . Positive_regulation TNF MEF2C 14515274 1147111 Following phosphorylation of MEF2C , activated *regulates* transcription of c-Jun but not [TNF-alpha] . Positive_regulation TNF MEFV 8478050 218656 Maximal production of [TNF] *required* gene transcription during the first 6 h of incubation with endotoxin . Positive_regulation TNF MET 20628900 2310245 In the presence of [TNF-alpha] , and Cys significantly *increased* the LPL activity , and Met also enhanced the LPL mRNA level . Positive_regulation TNF MICA 16698439 1560444 Here , we show that IL-2 , IL-4 , and IL-15 but not [TNF-alpha] or IFN-alpha *induced* expression in T lymphocytes present in peripheral blood mononuclear cells ( PBMCs ) , as assessed by Western blot . Positive_regulation TNF MICE 1932370 170055 are quite resistant to LPS toxicity but even a small dose *induced* a monophasic production of circulating [TNF] . Positive_regulation TNF MICE 20452378 2288456 treated with CLDC had significantly *increased* serum IFN-gamma , [TNF-alpha] , and IL-12 , suggesting a strong Th1 biased antiviral activation of the innate immune system . Positive_regulation TNF MICE 21872392 2491427 that received fullerenes exhibited increased proliferation of splenocytes and *increased* splenic production of IL-2 and [TNF-a] . Positive_regulation TNF MICE 22648862 2615352 from the 5FU ( 5-Fluorouracil ) group presented weight loss , ulcerations and inflammatory infiltration of neutrophils and eosinophils , *increased* expression of IL6 and [TNF-alpha] and increased intestinal permeability . Positive_regulation TNF MIF 10068127 594063 does induce secretion of IL-6 , but does not *induce* secretion of [TNFalpha] , IL-1beta , and GM-CSF . Positive_regulation TNF MIF 12635141 1068485 *induced* significant MIF and [tumour necrosis factor (TNF)-alpha] synthesis in cultured endothelial cells and the effect was blocked by neutralizing anti-MIF antibody . Positive_regulation TNF MIF 12635141 1068487 A similar blocking effect was observed when MIF stimulated endothelial cells were pretreated with neutralizing anti-TNF-alpha antibody or glucocorticoid , supporting the notion that *induced* [TNF-alpha] production via an amplifying pro-inflammatory loop . Positive_regulation TNF MIF 16317387 1487608 Exogenous , instilled into the lungs , *increased* alveolar keratinocyte derived chemokine ( KC ) , Macrophage inflammatory protein-2 (MIP2) , and [tumor necrosis factor alpha (TNFalpha)] at 3 h , and plasma KC and MIP2 at 6 h postinstillation . Positive_regulation TNF MIF 19406662 2082392 Pathogenic bacteria and [TNF] do not *induce* production of ( MIF ) by human monocytes . Positive_regulation TNF MIF 19601712 2137234 Furthermore , anti-TRX antibody inhibited *mediated* enhancement of [TNF-alpha] production from macrophage RAW264.7 cells . Positive_regulation TNF MIF 21269946 2380765 ADMA can up-regulate expression and *induce* [TNF-a] and IL-8 secretion in THP-1 monocyte derived macrophages . Positive_regulation TNF MIF 21977228 2493000 Lack of *caused* a reduction of [TNF-a] , IL-12 , IFN-? and IL-23 and an increased expression of IL-22 in ileal mucosa . Positive_regulation TNF MIF 22136975 2530482 released by isolated cold preserved livers , *induced* [TNF-a] and IL-1ß production by cultured peritoneal macrophages . Positive_regulation TNF MIF 24003215 2862184 Gremlin-1 binds with high affinity to MIF ( KD = 54 nm ) , as evidenced by surface plasmon resonance analysis and co-immunoprecipitation , and reduces *induced* release of [TNF-a] from macrophages . Positive_regulation TNF MIF 7683323 216429 and IFN-gamma synergize with lipid A to mediate migration inhibition but only IFN-gamma *induces* production of [TNF-alpha] and nitric oxide . Positive_regulation TNF MIF 7947826 277199 *induced* the secretion of [tumor necrosis factor-alpha] and stimulated nitric oxide production by macrophages primed with interferon-gamma . Positive_regulation TNF MIF 8195715 259178 In RAW 264.7 macrophages , secretion also was *induced* by [tumor necrosis factor alpha (TNF-alpha)] and IFN-gamma , but not by interleukins 1 beta or 6 . Positive_regulation TNF MIP 16856209 1607197 We have recently shown that antigen induced neutrophil migration into the peritoneum of immunized mice is mediated by which interacts with CCR1 and *induces* the sequential release of [TNF-alpha] and leukotriene B ( 4 ) ( LTB ( 4 ) ) . Positive_regulation TNF MIP 8597099 342602 Since previous studies had demonstrated that TNF alpha stimulates and CINC expression in vitro and that particle exposure *induces* [TNF alpha] production in rat lung we examined the role of TNF alpha in alpha quartz induced MIP-2 gene expression . Positive_regulation TNF MIPEP 10502561 648778 [TNF-alpha] also *induced* production from alveolar epithelial cells . Positive_regulation TNF MIPEP 10799303 691106 These data demonstrate that [TNF-alpha] *induces* expression of in endothelial cells and support the hypothesis that the anti-inflammatory action of dexamethasone may , at least in part , be attributable to an inhibition of MIP-2 induction on cytokine activated endothelial cells . Positive_regulation TNF MIPEP 10861785 705334 If added together , sICAM-1 and [TNF-alpha] synergistically *induced* production suggesting the involvement of two different pathways for MIP-2 regulation . Positive_regulation TNF MIPEP 16436136 1516386 Either SCF or TNF-alpha could induce release from HMC-1 cells of interleukin (IL)-8 , monocyte chemoattractant protein (MCP)-1 , regulated upon activation normal T-cell expressed and secreted ( RANTES ) , and I-309 , while SCF and [TNF-alpha] *induced* release of and interferon-gamma-inducible protein-10 (IP-10) , respectively . Positive_regulation TNF MIPEP 20846396 2325696 In the absence of any serum and in the presence of 10 % delipidated FBS , production of *induced* [TNF-a] and IL-8 in PMA differentiated THP-1 cells were similar whereas they were significantly decreased in the presence of 10 % FBS suggesting an inhibiting role of lipids present in FBS . Positive_regulation TNF MIR155 20948191 2343639 IFN-? and [TNF-a] synergistically *induce* which regulates TAB2/IP-10 expression in human mesangial cells . Positive_regulation TNF MIR155 21062749 2370990 Up-regulation of in macrophages *contributes* to increased [tumor necrosis factor] { alpha } ( TNF{alpha } ) production via increased mRNA half-life in alcoholic liver disease . Positive_regulation TNF MIR187 23071313 2694944 IL-10 induced negatively *regulates* [TNF-a] , IL-6 , and IL-12p40 production in TLR4 stimulated monocytes . Positive_regulation TNF MKL1 14630816 1210101 In contrast , in macrophages neither MyD88 , , nor I kappa B kinase 2 (IKK2) are *required* for NF-kappa B activation or [tumor necrosis factor alpha (TNF alpha)] , IL-6 , or IL-8 production , although Mal/TIRAP is still involved in the production of interferon beta (IFN beta) . Positive_regulation TNF MKL1 17255320 1691066 In addition , overexpression of dominant negative forms of MyD88 and significantly *down-regulated* the spontaneous production of cytokines [tumor necrosis factor-alpha] , IL-6 , and vascular endothelial growth factor , and enzymes MMP-1 , MMP-2 , MMP-3 , and MMP-13 in RA synovial membrane cell cultures . Positive_regulation TNF MKNK1 16111636 1448526 A selective Mnk inhibitor or siRNA mediated knockdown of *inhibits* [TNFalpha] production in T cells , whereas Mnk1 overexpression enhances expression of a reporter construct containing the TNFalpha 3'UTR . Positive_regulation TNF MLST8 22351078 2561121 The aim of this study was to investigate the *role* of in myocardial [TNF-a] expression during endotoxemia . Positive_regulation TNF MLYCD 11350737 814666 These data demonstrate that , like [TNF-alpha] , induction of MnSOD by LPS is *mediated* by and TLR4 in murine macrophages . Positive_regulation TNF MLYCD 21701985 2475930 The results indicated that mCD14-siRNA-224 effectively *inhibited* [TNF-a] , MIP-2 , and IL-6 release and NO production from LPS stimulated RAW 264.7 cells by down regulating mRNA accumulation and protein expression of specifically . Positive_regulation TNF MLYCD 22319522 2553766 In real-time PCR and western blotting analysis , PTX decreased *induced* [TNF-alpha] mRNA expression and proapoptotic unfolded protein response by ER stress ( GRP78 , p-eIF2 , ATF4 , IRE1a , CHOP , and p-JNK activation ) in vivo . Positive_regulation TNF MMP1 10362800 620150 [TNF-alpha] *induced* cathepsin S , , -3 , and -9 mRNA expression in a dose dependent manner : the maximal effect was observed at a concentration of 10 ng/ml , with appreciable increases observed at concentrations of 0.1 to 1.0 ng/ml . Positive_regulation TNF MMP1 10614779 575730 Although only hydroxamate inhibitors *inhibited* the basal processing and release of [TNF-alpha] , the PMA induced processing and release of TNF-alpha were inhibited not only by MMP inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin ( 3,4-DCI ) , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) . Positive_regulation TNF MMP1 11147175 760898 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that [TNF-alpha] may *induce* production followed by matrix degradation within foreign body granulomas . Positive_regulation TNF MMP1 11487149 845178 Northern hybridization showed that IL-1alpha and [TNF-alpha] *induced* significant gene expression , with only little effect on TIMP-1 gene . Positive_regulation TNF MMP1 11773040 899375 Isolated RMVECs did not significantly increase production directly in response to a hypoxic stimulus , but *required* the presence of exogenous [TNFalpha] . Positive_regulation TNF MMP1 12356583 993941 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with [tumor necrosis factor (TNF)-alpha] , known to induce matrix metalloproteinase (MMP) release , and/or neutrophil elastase (NE) , which can *induce* activation . Positive_regulation TNF MMP1 12913922 1129685 [TNF-a] stimulation *induced* IL-6 secretion by RA SFB ( 3-fold ) and OA SFB ( 4-fold ) , as well as secretion ( RA , 85-fold ; Positive_regulation TNF MMP1 12960156 1158181 [Tumor necrosis factor-alpha (TNFalpha)] and granulocyte macrophage colony stimulating factor ( GM-CSF ) individually enhance monocyte matrix metalloproteinase-9 (MMP-9) but *induce* only when added in combination . Positive_regulation TNF MMP1 12960156 1158189 IFNgamma *induced* in the presence of GM-CSF through the stimulation of [TNFalpha] production through a mechanism involving both p38 and ERK1/2 MAPKs , in which GM-CSF stimulated ERK1/2 whereas IFNgamma activated p38 . Positive_regulation TNF MMP1 14634122 1170893 IL-1beta and [TNF-alpha] *stimulated* FLSC extracellular signal regulated kinase ( ERK ) activation as well as and -13 release . Positive_regulation TNF MMP1 14673992 1178661 Specifically , OSM + [TNFalpha] *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation TNF MMP1 15044327 1272733 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to [TNF-alpha] dependent *induction* in the macrophages . Positive_regulation TNF MMP1 15102798 1239981 Treatment of B. burgdorferi infected cells with JAK and MAPK inhibitors significantly inhibited TNF-alpha induction , consistent with at least a partial role for [TNF-alpha] in B. burgdorferi *induced* expression in chondrocytes . Positive_regulation TNF MMP1 15893540 1407570 [Tumor necrosis factor alpha (TNFalpha)] has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses , and its release can be *inhibited* by inhibitors . Positive_regulation TNF MMP1 16549372 1582209 [TNF-alpha] and OSM *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation TNF MMP1 16549373 1582324 IL-1beta and [TNFalpha] strongly *induced* the expression of and -13 in SW1353 cells and HACs , whereas only TNFalpha was found to induce the expression of these two MMPs in JJ012 cells . Positive_regulation TNF MMP1 17940116 1849314 We hypothesized that IL-1beta and [TNF-alpha] may *induce* and MMP-3 activity to promote PTD by degrading decidual and fetal membranes and cervical extracellular matrix . Positive_regulation TNF MMP1 17990358 1821600 *promotes* secretion of [TNF-alpha] in a positive feedback manner to cause further injury in the colon mucosa . Positive_regulation TNF MMP1 18053242 1836233 LPS and [TNFalpha] *induced* collagen1 and fibronectin levels as well as the matrix degradation enzyme . Positive_regulation TNF MMP1 19055644 1999855 gene expression might be *induced* by [TNF-alpha] via the p50/p50 homodimer of NF-kappaB in activated human HSCs . Positive_regulation TNF MMP1 19435506 2106947 [TNF-alpha] does not *induce* expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation TNF MMP1 22922824 2672505 [TNF-a] with and without trauma significantly *induced* gene expression . Positive_regulation TNF MMP1 23603294 2795167 The expression of , MMP-3 , and MMP-9 *increased* in the presence of [TNF-a] , and the addition of infliximab reversed the increase . Positive_regulation TNF MMP1 9014820 405387 In support of this result , [TNF-alpha] stimulation *induced* membrane-type matrix metalloproteinase ( ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation TNF MMP1 9614183 509480 [Tumor necrosis factor-alpha (TNF-alpha)] alone did not *induce* expression in rat lung fibroblasts but did in rat skin fibroblasts , revealing tissue specificity in the regulation of this gene . Positive_regulation TNF MMP10 10614779 575731 Although only hydroxamate matrix metalloproteinase (MMP) inhibitors inhibited the basal processing and release of TNF-alpha , the PMA induced processing and release of [TNF-alpha] were *inhibited* not only by inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin ( 3,4-DCI ) , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) . Positive_regulation TNF MMP10 11147175 760899 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that [TNF-alpha] may *induce* production followed by matrix degradation within foreign body granulomas . Positive_regulation TNF MMP10 11773040 899376 Isolated RMVECs did not significantly increase production directly in response to a hypoxic stimulus , but *required* the presence of exogenous [TNFalpha] . Positive_regulation TNF MMP10 12356583 993942 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with [tumor necrosis factor (TNF)-alpha] , known to induce matrix metalloproteinase (MMP) release , and/or neutrophil elastase (NE) , which can *induce* activation . Positive_regulation TNF MMP10 14673992 1178662 Specifically , OSM + [TNFalpha] *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation TNF MMP10 15044327 1272734 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to [TNF-alpha] dependent *induction* in the macrophages . Positive_regulation TNF MMP10 15893540 1407571 [Tumor necrosis factor alpha (TNFalpha)] has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses , and its release can be *inhibited* by inhibitors . Positive_regulation TNF MMP10 16549372 1582210 [TNF-alpha] and OSM *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation TNF MMP10 19435506 2106948 [TNF-alpha] does not *induce* expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation TNF MMP10 9014820 405388 In support of this result , [TNF-alpha] stimulation *induced* membrane-type matrix metalloproteinase ( ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation TNF MMP11 10614779 575732 Although only hydroxamate inhibitors *inhibited* the basal processing and release of [TNF-alpha] , the PMA induced processing and release of TNF-alpha were inhibited not only by MMP inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin ( 3,4-DCI ) , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) . Positive_regulation TNF MMP11 11147175 760900 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that [TNF-alpha] may *induce* production followed by matrix degradation within foreign body granulomas . Positive_regulation TNF MMP11 11773040 899377 Isolated RMVECs did not significantly increase production directly in response to a hypoxic stimulus , but *required* the presence of exogenous [TNFalpha] . Positive_regulation TNF MMP11 12356583 993943 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with [tumor necrosis factor (TNF)-alpha] , known to induce matrix metalloproteinase (MMP) release , and/or neutrophil elastase (NE) , which can *induce* activation . Positive_regulation TNF MMP11 14673992 1178663 Specifically , OSM + [TNFalpha] *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation TNF MMP11 15044327 1272735 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to [TNF-alpha] dependent *induction* in the macrophages . Positive_regulation TNF MMP11 15893540 1407572 [Tumor necrosis factor alpha (TNFalpha)] has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses , and its release can be *inhibited* by inhibitors . Positive_regulation TNF MMP11 16549372 1582211 [TNF-alpha] and OSM *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation TNF MMP11 19435506 2106949 [TNF-alpha] does not *induce* expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation TNF MMP11 9014820 405389 In support of this result , [TNF-alpha] stimulation *induced* membrane-type matrix metalloproteinase ( ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation TNF MMP12 10614779 575733 Although only hydroxamate matrix metalloproteinase (MMP) inhibitors inhibited the basal processing and release of TNF-alpha , the PMA induced processing and release of [TNF-alpha] were *inhibited* not only by inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin ( 3,4-DCI ) , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) . Positive_regulation TNF MMP12 11147175 760901 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that [TNF-alpha] may *induce* production followed by matrix degradation within foreign body granulomas . Positive_regulation TNF MMP12 11704502 879096 Unlike basic fibroblast growth factor (bFGF) and transforming growth factor-beta ( TGF-beta ) , [tumor necrosis factor-alpha (TNF-alpha)] *induced* mRNA production in chondrosarcoma derived HTB-94 cells . Positive_regulation TNF MMP12 11773040 899378 Isolated RMVECs did not significantly increase production directly in response to a hypoxic stimulus , but *required* the presence of exogenous [TNFalpha] . Positive_regulation TNF MMP12 12356583 993944 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with [tumor necrosis factor (TNF)-alpha] , known to induce matrix metalloproteinase (MMP) release , and/or neutrophil elastase (NE) , which can *induce* activation . Positive_regulation TNF MMP12 14673992 1178664 Specifically , OSM + [TNFalpha] *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation TNF MMP12 15044327 1272736 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to [TNF-alpha] dependent *induction* in the macrophages . Positive_regulation TNF MMP12 15893540 1407573 [Tumor necrosis factor alpha (TNFalpha)] has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses , and its release can be *inhibited* by inhibitors . Positive_regulation TNF MMP12 16549372 1582212 [TNF-alpha] and OSM *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation TNF MMP12 19435506 2106950 [TNF-alpha] does not *induce* expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation TNF MMP12 9014820 405390 In support of this result , [TNF-alpha] stimulation *induced* membrane-type matrix metalloproteinase ( ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation TNF MMP13 10614779 575734 Although only hydroxamate inhibitors *inhibited* the basal processing and release of [TNF-alpha] , the PMA induced processing and release of TNF-alpha were inhibited not only by MMP inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin ( 3,4-DCI ) , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) . Positive_regulation TNF MMP13 11054671 745854 In these cell lines , [TNF-alpha] potently *induced* mRNA expression . Positive_regulation TNF MMP13 11147175 760902 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that [TNF-alpha] may *induce* production followed by matrix degradation within foreign body granulomas . Positive_regulation TNF MMP13 11773040 899379 Isolated RMVECs did not significantly increase production directly in response to a hypoxic stimulus , but *required* the presence of exogenous [TNFalpha] . Positive_regulation TNF MMP13 12356583 993945 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with [tumor necrosis factor (TNF)-alpha] , known to induce matrix metalloproteinase (MMP) release , and/or neutrophil elastase (NE) , which can *induce* activation . Positive_regulation TNF MMP13 14634122 1170894 IL-1beta and [TNF-alpha] *stimulated* FLSC extracellular signal regulated kinase ( ERK ) activation as well as release . Positive_regulation TNF MMP13 14673992 1178665 Specifically , OSM + [TNFalpha] *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation TNF MMP13 15044327 1272737 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to [TNF-alpha] dependent *induction* in the macrophages . Positive_regulation TNF MMP13 15893540 1407574 [Tumor necrosis factor alpha (TNFalpha)] has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses , and its release can be *inhibited* by inhibitors . Positive_regulation TNF MMP13 16549372 1582213 [TNF-alpha] and OSM *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation TNF MMP13 16549373 1582325 IL-1beta and [TNFalpha] strongly *induced* the expression of in SW1353 cells and HACs , whereas only TNFalpha was found to induce the expression of these two MMPs in JJ012 cells . Positive_regulation TNF MMP13 19435506 2106951 [TNF-alpha] does not *induce* expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation TNF MMP13 9014820 405391 In support of this result , [TNF-alpha] stimulation *induced* membrane-type matrix metalloproteinase ( ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation TNF MMP14 10614779 575735 Although only hydroxamate matrix metalloproteinase (MMP) inhibitors inhibited the basal processing and release of TNF-alpha , the PMA induced processing and release of [TNF-alpha] were *inhibited* not only by inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin ( 3,4-DCI ) , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) . Positive_regulation TNF MMP14 11112697 768056 We report that [TNF-(alpha)] significantly *induced* at the mRNA and protein levels when the dermal fibroblasts were grown in collagen . Positive_regulation TNF MMP14 11147175 760903 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that [TNF-alpha] may *induce* production followed by matrix degradation within foreign body granulomas . Positive_regulation TNF MMP14 11773040 899380 Isolated RMVECs did not significantly increase production directly in response to a hypoxic stimulus , but *required* the presence of exogenous [TNFalpha] . Positive_regulation TNF MMP14 12356583 993946 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with [tumor necrosis factor (TNF)-alpha] , known to induce matrix metalloproteinase (MMP) release , and/or neutrophil elastase (NE) , which can *induce* activation . Positive_regulation TNF MMP14 14673992 1178666 Specifically , OSM + [TNFalpha] *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation TNF MMP14 15044327 1272738 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to [TNF-alpha] dependent *induction* in the macrophages . Positive_regulation TNF MMP14 15893540 1407575 [Tumor necrosis factor alpha (TNFalpha)] has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses , and its release can be *inhibited* by inhibitors . Positive_regulation TNF MMP14 16549372 1582214 [TNF-alpha] and OSM *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation TNF MMP14 18277865 1872180 [TNF-alpha] *induces* MMP2 gelatinase activity and expression in an in vitro model of nucleus pulposus tissue degeneration . Positive_regulation TNF MMP14 18277865 1872210 Reporter constructs demonstrated that [TNF-alpha] *induced* transcriptional activation and that this response was dependant on ERK MAPK and Egr-1 . Positive_regulation TNF MMP14 18277865 1872212 As ERK also appeared to regulate MT1-MMP production , this suggests that [TNF-alpha] induction of MMP-2 gelatinase activity may be *regulated* by . Positive_regulation TNF MMP14 19435506 2106952 [TNF-alpha] does not *induce* expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation TNF MMP14 23266860 2741451 Role of PKC-a in *mediated* activation of proMMP-2 by [TNF-a] in pulmonary artery smooth muscle cells . Positive_regulation TNF MMP14 9014820 405392 In support of this result , [TNF-alpha] stimulation *induced* membrane-type matrix metalloproteinase ( ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation TNF MMP15 10614779 575736 Although only hydroxamate inhibitors *inhibited* the basal processing and release of [TNF-alpha] , the PMA induced processing and release of TNF-alpha were inhibited not only by MMP inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin ( 3,4-DCI ) , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) . Positive_regulation TNF MMP15 11147175 760904 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that [TNF-alpha] may *induce* production followed by matrix degradation within foreign body granulomas . Positive_regulation TNF MMP15 11773040 899381 Isolated RMVECs did not significantly increase production directly in response to a hypoxic stimulus , but *required* the presence of exogenous [TNFalpha] . Positive_regulation TNF MMP15 12356583 993947 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with [tumor necrosis factor (TNF)-alpha] , known to induce matrix metalloproteinase (MMP) release , and/or neutrophil elastase (NE) , which can *induce* activation . Positive_regulation TNF MMP15 14673992 1178667 Specifically , OSM + [TNFalpha] *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation TNF MMP15 15044327 1272739 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to [TNF-alpha] dependent *induction* in the macrophages . Positive_regulation TNF MMP15 15893540 1407576 [Tumor necrosis factor alpha (TNFalpha)] has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses , and its release can be *inhibited* by inhibitors . Positive_regulation TNF MMP15 16549372 1582215 [TNF-alpha] and OSM *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation TNF MMP15 19435506 2106953 [TNF-alpha] does not *induce* expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation TNF MMP15 9014820 405393 In support of this result , [TNF-alpha] stimulation *induced* membrane-type matrix metalloproteinase ( ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation TNF MMP16 10614779 575737 Although only hydroxamate matrix metalloproteinase (MMP) inhibitors inhibited the basal processing and release of TNF-alpha , the PMA induced processing and release of [TNF-alpha] were *inhibited* not only by inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin ( 3,4-DCI ) , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) . Positive_regulation TNF MMP16 11147175 760905 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that [TNF-alpha] may *induce* production followed by matrix degradation within foreign body granulomas . Positive_regulation TNF MMP16 11773040 899382 Isolated RMVECs did not significantly increase production directly in response to a hypoxic stimulus , but *required* the presence of exogenous [TNFalpha] . Positive_regulation TNF MMP16 12356583 993948 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with [tumor necrosis factor (TNF)-alpha] , known to induce matrix metalloproteinase (MMP) release , and/or neutrophil elastase (NE) , which can *induce* activation . Positive_regulation TNF MMP16 14673992 1178668 Specifically , OSM + [TNFalpha] *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation TNF MMP16 15044327 1272740 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to [TNF-alpha] dependent *induction* in the macrophages . Positive_regulation TNF MMP16 15893540 1407577 [Tumor necrosis factor alpha (TNFalpha)] has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses , and its release can be *inhibited* by inhibitors . Positive_regulation TNF MMP16 16549372 1582216 [TNF-alpha] and OSM *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation TNF MMP16 19435506 2106954 [TNF-alpha] does not *induce* expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation TNF MMP16 9014820 405394 In support of this result , [TNF-alpha] stimulation *induced* membrane-type matrix metalloproteinase ( ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation TNF MMP17 10614779 575738 Although only hydroxamate inhibitors *inhibited* the basal processing and release of [TNF-alpha] , the PMA induced processing and release of TNF-alpha were inhibited not only by MMP inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin ( 3,4-DCI ) , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) . Positive_regulation TNF MMP17 11147175 760906 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that [TNF-alpha] may *induce* production followed by matrix degradation within foreign body granulomas . Positive_regulation TNF MMP17 11773040 899383 Isolated RMVECs did not significantly increase production directly in response to a hypoxic stimulus , but *required* the presence of exogenous [TNFalpha] . Positive_regulation TNF MMP17 12356583 993949 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with [tumor necrosis factor (TNF)-alpha] , known to induce matrix metalloproteinase (MMP) release , and/or neutrophil elastase (NE) , which can *induce* activation . Positive_regulation TNF MMP17 14673992 1178669 Specifically , OSM + [TNFalpha] *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation TNF MMP17 15044327 1272741 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to [TNF-alpha] dependent *induction* in the macrophages . Positive_regulation TNF MMP17 15893540 1407578 [Tumor necrosis factor alpha (TNFalpha)] has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses , and its release can be *inhibited* by inhibitors . Positive_regulation TNF MMP17 16549372 1582217 [TNF-alpha] and OSM *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation TNF MMP17 19435506 2106955 [TNF-alpha] does not *induce* expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation TNF MMP17 9014820 405395 In support of this result , [TNF-alpha] stimulation *induced* membrane-type matrix metalloproteinase ( ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation TNF MMP19 10614779 575739 Although only hydroxamate matrix metalloproteinase (MMP) inhibitors inhibited the basal processing and release of TNF-alpha , the PMA induced processing and release of [TNF-alpha] were *inhibited* not only by inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin ( 3,4-DCI ) , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) . Positive_regulation TNF MMP19 11147175 760907 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that [TNF-alpha] may *induce* production followed by matrix degradation within foreign body granulomas . Positive_regulation TNF MMP19 11773040 899384 Isolated RMVECs did not significantly increase production directly in response to a hypoxic stimulus , but *required* the presence of exogenous [TNFalpha] . Positive_regulation TNF MMP19 12356583 993950 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with [tumor necrosis factor (TNF)-alpha] , known to induce matrix metalloproteinase (MMP) release , and/or neutrophil elastase (NE) , which can *induce* activation . Positive_regulation TNF MMP19 14673992 1178670 Specifically , OSM + [TNFalpha] *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation TNF MMP19 15044327 1272742 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to [TNF-alpha] dependent *induction* in the macrophages . Positive_regulation TNF MMP19 15893540 1407579 [Tumor necrosis factor alpha (TNFalpha)] has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses , and its release can be *inhibited* by inhibitors . Positive_regulation TNF MMP19 16549372 1582218 [TNF-alpha] and OSM *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation TNF MMP19 19435506 2106956 [TNF-alpha] does not *induce* expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation TNF MMP19 9014820 405396 In support of this result , [TNF-alpha] stimulation *induced* membrane-type matrix metalloproteinase ( ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation TNF MMP2 10614779 575740 Although only hydroxamate inhibitors *inhibited* the basal processing and release of [TNF-alpha] , the PMA induced processing and release of TNF-alpha were inhibited not only by MMP inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin ( 3,4-DCI ) , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) . Positive_regulation TNF MMP2 11112697 768058 Based on these results and previous reports , we propose a model to explain [TNF-(alpha)] *activation* of in human skin . Positive_regulation TNF MMP2 11147175 760908 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that [TNF-alpha] may *induce* production followed by matrix degradation within foreign body granulomas . Positive_regulation TNF MMP2 11480246 843585 [TNF-alpha] and IL-1 beta *induced* increases in the concentrations of MMP-1 , MMP-3 , and MMP-9 , but not in or tissue inhibitor of matrix metalloproteinase ( TIMP ) -1 or -2 . Positive_regulation TNF MMP2 11773040 899385 Isolated RMVECs did not significantly increase production directly in response to a hypoxic stimulus , but *required* the presence of exogenous [TNFalpha] . Positive_regulation TNF MMP2 12356583 993951 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with [tumor necrosis factor (TNF)-alpha] , known to induce matrix metalloproteinase (MMP) release , and/or neutrophil elastase (NE) , which can *induce* activation . Positive_regulation TNF MMP2 14673992 1178671 Specifically , OSM + [TNFalpha] *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation TNF MMP2 15044327 1272743 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to [TNF-alpha] dependent *induction* in the macrophages . Positive_regulation TNF MMP2 15893540 1407580 [Tumor necrosis factor alpha (TNFalpha)] has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses , and its release can be *inhibited* by inhibitors . Positive_regulation TNF MMP2 16549372 1582219 [TNF-alpha] and OSM *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation TNF MMP2 18277865 1872181 [TNF-alpha] *induces* gelatinase activity and MT1-MMP expression in an in vitro model of nucleus pulposus tissue degeneration . Positive_regulation TNF MMP2 19435506 2106957 [TNF-alpha] does not *induce* expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation TNF MMP2 20007453 2210577 [TNF] did not *induce* expression . Positive_regulation TNF MMP2 20010305 2191293 Mycobacterium leprae and [TNF] *induced* upregulation of and MMP-9 and increased secretion of these enzymes in cultured ST88-14 cells . Positive_regulation TNF MMP2 21518085 2423045 It has been reported that [tumor necrosis factor-a (TNF-a)] *induces* the production of and transforming growth factor-ß1 ( TGF-ß1 ) in fibroblasts . Positive_regulation TNF MMP2 21518085 2423051 Taken together , our results demonstrate that [TNF-a] *induced* an increase of and TGF-ß1 in lung fibroblasts , and the TGF-ß1 attenuated the up-regulation of MMP-2 . Positive_regulation TNF MMP2 21573233 2430247 In summary , our study implies a *role* of in the regulation of [TNF-a] mediated constitutive NF-?B activation and Fas mediated JNK mediated apoptosis in glioma xenograft cells in vitro and in vivo . Positive_regulation TNF MMP2 22676642 2638508 Inhibition of *suppressed* CCI induced mechanical allodynia and concomitant [TNF-a] and IL-17A expression in nerves . Positive_regulation TNF MMP2 9014820 405397 In support of this result , [TNF-alpha] stimulation *induced* membrane-type matrix metalloproteinase ( ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation TNF MMP2 9014820 405426 Our results suggest that [TNF-alpha] *induces* activation in part by up-regulating MT-MMP expression , thus representing a new mechanism for cytokine mediated articular destruction in rheumatoid arthritis ( RA ) . Positive_regulation TNF MMP20 10614779 575741 Although only hydroxamate matrix metalloproteinase (MMP) inhibitors inhibited the basal processing and release of TNF-alpha , the PMA induced processing and release of [TNF-alpha] were *inhibited* not only by inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin ( 3,4-DCI ) , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) . Positive_regulation TNF MMP20 11147175 760909 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that [TNF-alpha] may *induce* production followed by matrix degradation within foreign body granulomas . Positive_regulation TNF MMP20 11773040 899386 Isolated RMVECs did not significantly increase production directly in response to a hypoxic stimulus , but *required* the presence of exogenous [TNFalpha] . Positive_regulation TNF MMP20 12356583 993952 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with [tumor necrosis factor (TNF)-alpha] , known to induce matrix metalloproteinase (MMP) release , and/or neutrophil elastase (NE) , which can *induce* activation . Positive_regulation TNF MMP20 14673992 1178672 Specifically , OSM + [TNFalpha] *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation TNF MMP20 15044327 1272744 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to [TNF-alpha] dependent *induction* in the macrophages . Positive_regulation TNF MMP20 15893540 1407581 [Tumor necrosis factor alpha (TNFalpha)] has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses , and its release can be *inhibited* by inhibitors . Positive_regulation TNF MMP20 16549372 1582220 [TNF-alpha] and OSM *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation TNF MMP20 19435506 2106958 [TNF-alpha] does not *induce* expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation TNF MMP20 9014820 405398 In support of this result , [TNF-alpha] stimulation *induced* membrane-type matrix metalloproteinase ( ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation TNF MMP21 10614779 575728 Although only hydroxamate inhibitors *inhibited* the basal processing and release of [TNF-alpha] , the PMA induced processing and release of TNF-alpha were inhibited not only by MMP inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin ( 3,4-DCI ) , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) . Positive_regulation TNF MMP21 11147175 760896 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that [TNF-alpha] may *induce* production followed by matrix degradation within foreign body granulomas . Positive_regulation TNF MMP21 11773040 899373 Isolated RMVECs did not significantly increase production directly in response to a hypoxic stimulus , but *required* the presence of exogenous [TNFalpha] . Positive_regulation TNF MMP21 12356583 993939 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with [tumor necrosis factor (TNF)-alpha] , known to induce matrix metalloproteinase (MMP) release , and/or neutrophil elastase (NE) , which can *induce* activation . Positive_regulation TNF MMP21 14673992 1178659 Specifically , OSM + [TNFalpha] *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation TNF MMP21 15044327 1272731 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to [TNF-alpha] dependent *induction* in the macrophages . Positive_regulation TNF MMP21 15893540 1407568 [Tumor necrosis factor alpha (TNFalpha)] has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses , and its release can be *inhibited* by inhibitors . Positive_regulation TNF MMP21 16549372 1582207 [TNF-alpha] and OSM *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation TNF MMP21 19435506 2106945 [TNF-alpha] does not *induce* expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation TNF MMP21 9014820 405385 In support of this result , [TNF-alpha] stimulation *induced* membrane-type matrix metalloproteinase ( ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation TNF MMP24 10614779 575742 Although only hydroxamate inhibitors *inhibited* the basal processing and release of [TNF-alpha] , the PMA induced processing and release of TNF-alpha were inhibited not only by MMP inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin ( 3,4-DCI ) , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) . Positive_regulation TNF MMP24 11147175 760910 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that [TNF-alpha] may *induce* production followed by matrix degradation within foreign body granulomas . Positive_regulation TNF MMP24 11773040 899387 Isolated RMVECs did not significantly increase production directly in response to a hypoxic stimulus , but *required* the presence of exogenous [TNFalpha] . Positive_regulation TNF MMP24 12356583 993953 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with [tumor necrosis factor (TNF)-alpha] , known to induce matrix metalloproteinase (MMP) release , and/or neutrophil elastase (NE) , which can *induce* activation . Positive_regulation TNF MMP24 14673992 1178673 Specifically , OSM + [TNFalpha] *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation TNF MMP24 15044327 1272745 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to [TNF-alpha] dependent *induction* in the macrophages . Positive_regulation TNF MMP24 15893540 1407582 [Tumor necrosis factor alpha (TNFalpha)] has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses , and its release can be *inhibited* by inhibitors . Positive_regulation TNF MMP24 16549372 1582221 [TNF-alpha] and OSM *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation TNF MMP24 19435506 2106959 [TNF-alpha] does not *induce* expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation TNF MMP24 9014820 405399 In support of this result , [TNF-alpha] stimulation *induced* membrane-type matrix metalloproteinase ( ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation TNF MMP25 10614779 575725 Although only hydroxamate matrix metalloproteinase (MMP) inhibitors inhibited the basal processing and release of TNF-alpha , the PMA induced processing and release of [TNF-alpha] were *inhibited* not only by inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin ( 3,4-DCI ) , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) . Positive_regulation TNF MMP25 11147175 760893 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that [TNF-alpha] may *induce* production followed by matrix degradation within foreign body granulomas . Positive_regulation TNF MMP25 11773040 899370 Isolated RMVECs did not significantly increase production directly in response to a hypoxic stimulus , but *required* the presence of exogenous [TNFalpha] . Positive_regulation TNF MMP25 12356583 993936 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with [tumor necrosis factor (TNF)-alpha] , known to induce matrix metalloproteinase (MMP) release , and/or neutrophil elastase (NE) , which can *induce* activation . Positive_regulation TNF MMP25 14673992 1178656 Specifically , OSM + [TNFalpha] *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation TNF MMP25 15044327 1272728 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to [TNF-alpha] dependent *induction* in the macrophages . Positive_regulation TNF MMP25 15893540 1407565 [Tumor necrosis factor alpha (TNFalpha)] has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses , and its release can be *inhibited* by inhibitors . Positive_regulation TNF MMP25 16549372 1582204 [TNF-alpha] and OSM *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation TNF MMP25 19435506 2106942 [TNF-alpha] does not *induce* expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation TNF MMP25 9014820 405382 In support of this result , [TNF-alpha] stimulation *induced* membrane-type matrix metalloproteinase ( ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation TNF MMP26 10614779 575726 Although only hydroxamate inhibitors *inhibited* the basal processing and release of [TNF-alpha] , the PMA induced processing and release of TNF-alpha were inhibited not only by MMP inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin ( 3,4-DCI ) , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) . Positive_regulation TNF MMP26 11147175 760894 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that [TNF-alpha] may *induce* production followed by matrix degradation within foreign body granulomas . Positive_regulation TNF MMP26 11773040 899371 Isolated RMVECs did not significantly increase production directly in response to a hypoxic stimulus , but *required* the presence of exogenous [TNFalpha] . Positive_regulation TNF MMP26 12356583 993937 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with [tumor necrosis factor (TNF)-alpha] , known to induce matrix metalloproteinase (MMP) release , and/or neutrophil elastase (NE) , which can *induce* activation . Positive_regulation TNF MMP26 14673992 1178657 Specifically , OSM + [TNFalpha] *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation TNF MMP26 15044327 1272729 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to [TNF-alpha] dependent *induction* in the macrophages . Positive_regulation TNF MMP26 15893540 1407566 [Tumor necrosis factor alpha (TNFalpha)] has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses , and its release can be *inhibited* by inhibitors . Positive_regulation TNF MMP26 16549372 1582205 [TNF-alpha] and OSM *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation TNF MMP26 19435506 2106943 [TNF-alpha] does not *induce* expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation TNF MMP26 9014820 405383 In support of this result , [TNF-alpha] stimulation *induced* membrane-type matrix metalloproteinase ( ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation TNF MMP27 10614779 575727 Although only hydroxamate matrix metalloproteinase (MMP) inhibitors inhibited the basal processing and release of TNF-alpha , the PMA induced processing and release of [TNF-alpha] were *inhibited* not only by inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin ( 3,4-DCI ) , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) . Positive_regulation TNF MMP27 11147175 760895 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that [TNF-alpha] may *induce* production followed by matrix degradation within foreign body granulomas . Positive_regulation TNF MMP27 11773040 899372 Isolated RMVECs did not significantly increase production directly in response to a hypoxic stimulus , but *required* the presence of exogenous [TNFalpha] . Positive_regulation TNF MMP27 12356583 993938 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with [tumor necrosis factor (TNF)-alpha] , known to induce matrix metalloproteinase (MMP) release , and/or neutrophil elastase (NE) , which can *induce* activation . Positive_regulation TNF MMP27 14673992 1178658 Specifically , OSM + [TNFalpha] *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation TNF MMP27 15044327 1272730 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to [TNF-alpha] dependent *induction* in the macrophages . Positive_regulation TNF MMP27 15893540 1407567 [Tumor necrosis factor alpha (TNFalpha)] has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses , and its release can be *inhibited* by inhibitors . Positive_regulation TNF MMP27 16549372 1582206 [TNF-alpha] and OSM *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation TNF MMP27 19435506 2106944 [TNF-alpha] does not *induce* expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation TNF MMP27 9014820 405384 In support of this result , [TNF-alpha] stimulation *induced* membrane-type matrix metalloproteinase ( ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation TNF MMP28 10614779 575729 Although only hydroxamate matrix metalloproteinase (MMP) inhibitors inhibited the basal processing and release of TNF-alpha , the PMA induced processing and release of [TNF-alpha] were *inhibited* not only by inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin ( 3,4-DCI ) , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) . Positive_regulation TNF MMP28 11147175 760897 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that [TNF-alpha] may *induce* production followed by matrix degradation within foreign body granulomas . Positive_regulation TNF MMP28 11773040 899374 Isolated RMVECs did not significantly increase production directly in response to a hypoxic stimulus , but *required* the presence of exogenous [TNFalpha] . Positive_regulation TNF MMP28 12356583 993940 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with [tumor necrosis factor (TNF)-alpha] , known to induce matrix metalloproteinase (MMP) release , and/or neutrophil elastase (NE) , which can *induce* activation . Positive_regulation TNF MMP28 14673992 1178660 Specifically , OSM + [TNFalpha] *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation TNF MMP28 15044327 1272732 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to [TNF-alpha] dependent *induction* in the macrophages . Positive_regulation TNF MMP28 15893540 1407569 [Tumor necrosis factor alpha (TNFalpha)] has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses , and its release can be *inhibited* by inhibitors . Positive_regulation TNF MMP28 16549372 1582208 [TNF-alpha] and OSM *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation TNF MMP28 19435506 2106946 [TNF-alpha] does not *induce* expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation TNF MMP28 9014820 405386 In support of this result , [TNF-alpha] stimulation *induced* membrane-type matrix metalloproteinase ( ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation TNF MMP3 10614779 575743 Although only hydroxamate matrix metalloproteinase (MMP) inhibitors inhibited the basal processing and release of TNF-alpha , the PMA induced processing and release of [TNF-alpha] were *inhibited* not only by inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin ( 3,4-DCI ) , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) . Positive_regulation TNF MMP3 11147175 760911 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that [TNF-alpha] may *induce* production followed by matrix degradation within foreign body granulomas . Positive_regulation TNF MMP3 11773040 899388 Isolated RMVECs did not significantly increase production directly in response to a hypoxic stimulus , but *required* the presence of exogenous [TNFalpha] . Positive_regulation TNF MMP3 12356583 993954 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with [tumor necrosis factor (TNF)-alpha] , known to induce matrix metalloproteinase (MMP) release , and/or neutrophil elastase (NE) , which can *induce* activation . Positive_regulation TNF MMP3 12825130 1104465 In human colonic SEMFs , MMP-3 secretion and mRNA expression were *induced* by IL-17 , IL-1beta , and [TNF-alpha] . Positive_regulation TNF MMP3 14673992 1178674 Specifically , OSM + [TNFalpha] *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation TNF MMP3 15044327 1272746 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to [TNF-alpha] dependent *induction* in the macrophages . Positive_regulation TNF MMP3 15893540 1407583 [Tumor necrosis factor alpha (TNFalpha)] has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses , and its release can be *inhibited* by inhibitors . Positive_regulation TNF MMP3 16549372 1582222 [TNF-alpha] and OSM *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation TNF MMP3 16574073 1543482 Tumor necrosis factor ( [TNF-alpha] ) stimulation *induced* increased expression of mu-calpain , m-calpain , and in these cells , as well as the release of calpain and MMP-3 into the culture medium . Positive_regulation TNF MMP3 17940116 1849315 We hypothesized that IL-1beta and [TNF-alpha] may *induce* matrix metalloproteinase (MMP)-1 and activity to promote PTD by degrading decidual and fetal membranes and cervical extracellular matrix . Positive_regulation TNF MMP3 18283281 1919288 Adipocytes accumulated in the visceral area change their function to *induce* [tumor necrosis factor-alpha (TNF-alpha)] secretion with concomitant induction in mice . Positive_regulation TNF MMP3 19435506 2106960 [TNF-alpha] does not *induce* expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation TNF MMP3 20511551 2276908 The inhibition of , -8 , or -9 significantly reduced NO and reactive oxygen species levels and *suppressed* the expression of [TNF-alpha] and IL-1beta . Positive_regulation TNF MMP3 23603294 2795168 The expression of MMP-1 , , and MMP-9 *increased* in the presence of [TNF-a] , and the addition of infliximab reversed the increase . Positive_regulation TNF MMP3 7636301 317456 This mutant [TNF-alpha] markedly *induced* collagenase and gene expression in dermal fibroblasts , the maximal activation ( up to 42-fold ) being 65 % -89 % of that noted with wild-type human TNF-alpha . Positive_regulation TNF MMP3 9014820 405400 In support of this result , [TNF-alpha] stimulation *induced* membrane-type matrix metalloproteinase ( ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation TNF MMP7 10614779 575744 Although only hydroxamate inhibitors *inhibited* the basal processing and release of [TNF-alpha] , the PMA induced processing and release of TNF-alpha were inhibited not only by MMP inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin ( 3,4-DCI ) , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) . Positive_regulation TNF MMP7 10642592 660962 *dependent* release of [tumor necrosis factor-alpha] in a model of herniated disc resorption . Positive_regulation TNF MMP7 10642592 660967 was *required* for the release of the cytokine [TNF-alpha] from peritoneal macrophages . Positive_regulation TNF MMP7 11147175 760912 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that [TNF-alpha] may *induce* production followed by matrix degradation within foreign body granulomas . Positive_regulation TNF MMP7 11773040 899389 Isolated RMVECs did not significantly increase production directly in response to a hypoxic stimulus , but *required* the presence of exogenous [TNFalpha] . Positive_regulation TNF MMP7 12356583 993955 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with [tumor necrosis factor (TNF)-alpha] , known to induce matrix metalloproteinase (MMP) release , and/or neutrophil elastase (NE) , which can *induce* activation . Positive_regulation TNF MMP7 14673992 1178675 Specifically , OSM + [TNFalpha] *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation TNF MMP7 15044327 1272747 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to [TNF-alpha] dependent *induction* in the macrophages . Positive_regulation TNF MMP7 15893540 1407584 [Tumor necrosis factor alpha (TNFalpha)] has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses , and its release can be *inhibited* by inhibitors . Positive_regulation TNF MMP7 16549372 1582223 [TNF-alpha] and OSM *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation TNF MMP7 18252806 1895825 TNF-alpha *induces* the expression of transcripts for inflammatory mediators interleukin (IL)-6 , IL-8 , regulated on activation normal T cell expressed and secreted , [TNF-alpha] , granulocyte macrophage-colony stimulating factor ( GM-CSF ) , and monocyte chemoattractant protein (MCP)-1 and also invasion mediators , MMP-9 , and intracellular adhesion molecule-1 . Positive_regulation TNF MMP7 19435506 2106961 [TNF-alpha] does not *induce* expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation TNF MMP7 9014820 405401 In support of this result , [TNF-alpha] stimulation *induced* membrane-type matrix metalloproteinase ( ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation TNF MMP8 10614779 575745 Although only hydroxamate matrix metalloproteinase (MMP) inhibitors inhibited the basal processing and release of TNF-alpha , the PMA induced processing and release of [TNF-alpha] were *inhibited* not only by inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin ( 3,4-DCI ) , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) . Positive_regulation TNF MMP8 11147175 760913 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that [TNF-alpha] may *induce* production followed by matrix degradation within foreign body granulomas . Positive_regulation TNF MMP8 11773040 899390 Isolated RMVECs did not significantly increase production directly in response to a hypoxic stimulus , but *required* the presence of exogenous [TNFalpha] . Positive_regulation TNF MMP8 12356583 993956 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with [tumor necrosis factor (TNF)-alpha] , known to induce matrix metalloproteinase (MMP) release , and/or neutrophil elastase (NE) , which can *induce* activation . Positive_regulation TNF MMP8 14673992 1178676 Specifically , OSM + [TNFalpha] *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation TNF MMP8 15044327 1272748 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to [TNF-alpha] dependent *induction* in the macrophages . Positive_regulation TNF MMP8 15893540 1407585 [Tumor necrosis factor alpha (TNFalpha)] has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses , and its release can be *inhibited* by inhibitors . Positive_regulation TNF MMP8 16549372 1582224 [TNF-alpha] and OSM *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation TNF MMP8 19435506 2106962 [TNF-alpha] does not *induce* expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation TNF MMP8 20511551 2276910 Notably , inhibitor *suppressed* [TNF-alpha] production more efficaciously than MMP-3 or MMP-9 inhibitors . Positive_regulation TNF MMP8 9014820 405402 In support of this result , [TNF-alpha] stimulation *induced* membrane-type matrix metalloproteinase ( ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation TNF MMP9 10614779 575746 Although only hydroxamate inhibitors *inhibited* the basal processing and release of [TNF-alpha] , the PMA induced processing and release of TNF-alpha were inhibited not only by MMP inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin ( 3,4-DCI ) , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) . Positive_regulation TNF MMP9 10943866 721472 [TNFalpha] *induced* the production of in the ACpRc-1 cell clone , but greatly suppressed MMP-9 production in ACMT-6 and ACMT-7 clones . Positive_regulation TNF MMP9 11132772 760232 MMP-3 ) and gelatin zymography demonstrated that [TNF-alpha] *induced* production in human lung fibroblast , whereas PDGF alone did not . Positive_regulation TNF MMP9 11147175 760914 These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes , MMP-2 and MMP-9 , suggesting that [TNF-alpha] may *induce* production followed by matrix degradation within foreign body granulomas . Positive_regulation TNF MMP9 11297541 819938 In this report we demonstrate that [tumor necrosis factor-alpha (TNF-alpha)] and transforming growth factor-beta ( TGF-beta ) synergistically *induce* in human skin as well as isolated dermal fibroblasts and epidermal keratinocytes . Positive_regulation TNF MMP9 11310848 804855 Transforming growth factor-beta suppresses [tumor necrosis factor] alpha *induced* expression in monocytes . Positive_regulation TNF MMP9 11704541 879292 We demonstrated that [TNF-alpha] *induced* at both the protein and mRNA levels in human bronchial epithelial cells and that interleukin-1 beta did not . Positive_regulation TNF MMP9 11704541 879297 These results suggest that [TNF-alpha] *induces* the expression of in human bronchial epithelial cells and that this induction is mediated via the NF-kappa B-mediated pathway . Positive_regulation TNF MMP9 11773040 899391 Isolated RMVECs did not significantly increase production directly in response to a hypoxic stimulus , but *required* the presence of exogenous [TNFalpha] . Positive_regulation TNF MMP9 11813159 907412 Chemokine stimulation of monocyte *requires* endogenous [TNF-alpha] . Positive_regulation TNF MMP9 12115190 964090 Although [TNFalpha] *induced* the production of in NS-SV-AC cells , this production was greatly suppressed when cells were pretreated with cepharanthine , followed by treatment with both TNFalpha and cepharanthine . Positive_regulation TNF MMP9 12356583 993957 Using the three-dimensional collagen gel culture system , fibroblasts ( HFL-1 ) were cultured with [tumor necrosis factor (TNF)-alpha] , known to induce matrix metalloproteinase (MMP) release , and/or neutrophil elastase (NE) , which can *induce* activation . Positive_regulation TNF MMP9 12475184 1023527 The solution of Abeta ( 5 microM ) formed by 2-h incubation at room temperature *induced* [tumour necrosis factor-alpha (TNF-alpha)] and interleukin (IL)-6 levels by 55 and 45 % , respectively , and increased gelatinase B activity by 67 % , while exposure of cells to the ACT/Abeta1-42 mixture ( 1 : 10 molar ratio ACT : Abeta1-42 ) under the same experimental conditions showed no effect on IL-6 levels or activity , but strongly induced TNF-alpha ( by 190 % ) , compared to the controls . Positive_regulation TNF MMP9 12488366 1033082 Furthermore , [TNFalpha] *induced* the expression of Sertoli cell collagen alpha3 ( IV ) , ( matrix metalloprotease-9 , MMP-9 ) and tissue inhibitor of metalloproteases-1 but not gelatinase A ( matrix metalloprotease-2 ) , and promoted the activation of pro-MMP-9 . Positive_regulation TNF MMP9 14673992 1178677 Specifically , OSM + [TNFalpha] *induced* marked synovial hyperplasia , inflammation , and cartilage and bone destruction with a concomitant increase in expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage . Positive_regulation TNF MMP9 14766231 1207551 [TNF-alpha] *induced* rapid and robust release from eosinophils . Positive_regulation TNF MMP9 14998513 1216641 [TNFalpha] strongly *induced* . Positive_regulation TNF MMP9 15044327 1272749 In summary , we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to [TNF-alpha] dependent *induction* in the macrophages . Positive_regulation TNF MMP9 15537504 1336501 Additionally , [TNFalpha] ( 1-10 ng/ml ) significantly ( P < 0.01 ) *increased* myofibroblast invasion , with a concomitant increase in secretion , that was due to increased MMP-9 mRNA levels . Positive_regulation TNF MMP9 15893540 1407586 [Tumor necrosis factor alpha (TNFalpha)] has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses , and its release can be *inhibited* by inhibitors . Positive_regulation TNF MMP9 16079290 1442665 [TNF-alpha] *induced* the expression of . Positive_regulation TNF MMP9 16272296 1479298 , secreted by activated monocytes , degrades matrix proteins , disrupts basal lamina , and *activates* [TNF-alpha] from its precursors . Positive_regulation TNF MMP9 16350852 1492420 But neither p38 MAP kinase nor JNK inhibitor had an effect on [TNF-alpha] *induced* expression , suggesting that ERK activation is required for the MMP-9 induction by TNF-alpha . Positive_regulation TNF MMP9 16434697 1540478 [TNF-alpha] *induced* transcription by threefold , but no significant difference was observed in MMP-9 mRNA steady-state between normoxia and hypoxia , which inhibited the trafficking of proMMP-9 via secretory vesicles and increased the intracellular accumulation of proMMP-9 in the cells by 47 % and 62 % compared with normoxia ( P < 0.05 ) , as evaluated by zymography of cellular extracts and confocal microscopy , respectively . Positive_regulation TNF MMP9 16540379 1555345 In this study , we investigated the inhibitory effect of SM on [TNF-alpha] *induced* human aortic smooth muscle cells ( HASMC ) migration and activity . Positive_regulation TNF MMP9 16549372 1582225 [TNF-alpha] and OSM *induced* a pronounced increase in activity , which was strongly inhibited by calcitonin . Positive_regulation TNF MMP9 16624086 1551777 The expression and activity of can be *induced* by [TNFalpha] , and the induction was possibly related with the NF-kappaB mediated signal transduction pathway . Positive_regulation TNF MMP9 16870179 1593106 Activation of toll-like receptor-9 *induces* expression through Akt and [tumor necrosis factor-alpha] signaling . Positive_regulation TNF MMP9 16924232 1692186 [TNF] *induced* the expression of NF-kappaB regulated gene products cyclin D1 , c-Myc , , survivin , X-linked inhibitor-of-apoptosis protein ( IAP ) , IAP1 , Bcl-x ( L ) , A1/Bfl-1 and Fas associated death domain protein-like IL-1beta converting enzyme-inhibitory protein in wild-type MEF but not in PKR-/- cells . Positive_regulation TNF MMP9 16966323 1639861 In addition , increased secretion of [tumor necrosis factor (TNF)-alpha] , interleukin (IL)-1beta , and IL-6 *induced* secretion and synthesis in AM1 or SS1 strain infected mice suggesting elicitation of pro-inflammatory cytokines by both cag- and cag+ genotype . Positive_regulation TNF MMP9 17158602 1701110 [TNF-alpha] *induces* expression via activation of Src/EGFR , PDGFR/PI3K/Akt cascade and promotion of NF-kappaB/p300 binding in human tracheal smooth muscle cells . Positive_regulation TNF MMP9 17158602 1701115 In human tracheal smooth muscle cells , [TNF-alpha] *induced* expression and Akt phosphorylation in a time dependent manner , which was attenuated by the inhibitors of Src ( PP1 ) , epidermal growth factor receptor ( AG1478 ) , PDGFR ( AG1296 ) , and PI3K ( LY294002 ) , respectively , revealed by reporter gene assay , RT-PCR , zymographic , and Western blot analyses . Positive_regulation TNF MMP9 17327485 1740883 We showed that in human monocytes , the proinflammatory cytokine [TNF-alpha] *induced* secretion and increased fragmentation of FN into distinct fragments . Positive_regulation TNF MMP9 17357478 1665121 The presents study suggested that the expression and activity of from AM can be *induced* by [TNF-alpha] , and TNF-alpha/NF-kappaB signal pathway may play an important role in the induction . Positive_regulation TNF MMP9 17362932 1727444 *regulates* [TNF-alpha] and FasL expression in neuronal , glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis . Positive_regulation TNF MMP9 17704356 1806020 [TNF-alpha] *induced* a significant up-regulation of ( MMP-9 ) , stromelysin-1 ( MMP-3 ) , and COX-2 . Positive_regulation TNF MMP9 17897957 1824028 Our results also suggest that [TNF-alpha] *induces* expression in muscle cells through the recruitment of TRAF-2 , Fas associated protein with death domain , and TNF receptor associated protein with death domain but not NIK or TRAF-6 proteins . Positive_regulation TNF MMP9 17988825 1931711 [TNF-alpha] *induced* the expression in HepG2 cells . Positive_regulation TNF MMP9 18222174 1871082 [TNF-alpha] *induced* expression by NF-kappaB dependent pathway . Positive_regulation TNF MMP9 18252806 1895826 TNF-alpha *induces* the expression of transcripts for inflammatory mediators interleukin (IL)-6 , IL-8 , regulated on activation normal T cell expressed and secreted , [TNF-alpha] , granulocyte macrophage-colony stimulating factor ( GM-CSF ) , and monocyte chemoattractant protein (MCP)-1 and also invasion mediators matrix metalloproteinase (MMP)-7 , , and intracellular adhesion molecule-1 . Positive_regulation TNF MMP9 18336852 1912232 [Tumor necrosis factor-alpha] *induces* expression via p42/p44 MAPK , JNK , and nuclear factor-kappaB in A549 cells . Positive_regulation TNF MMP9 18357389 1887727 In conclusion , the findings of the present study indicate that [TNF-alpha] *induces* expression in HT1376 cells by activating transcription factors , which are involved in the ERK1/2- and p38 MAP kinase mediated control of MMP-9 regulation , namely , NF-kappaB , AP-1 and Sp-1 . Positive_regulation TNF MMP9 18449943 1932936 Gelatin zymography confirmed that LPS and [TNF-alpha] *induced* strong expression of in microglia but not astrocytes . Positive_regulation TNF MMP9 19218340 2039514 The [TNF-alpha/TNF-receptor] 1 (TNF-R1) interaction *induced* production and activation , as well as COX-2 overexpression and PGE2 production , and increased the migration of CC cells . Positive_regulation TNF MMP9 19298660 2056095 [Tumor necrosis factor-alpha] *induced* expression of through p21 activated kinase-1 . Positive_regulation TNF MMP9 19435506 2106963 [TNF-alpha] does not *induce* expression to the same degree as stimulation by IL-1beta , but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2 . Positive_regulation TNF MMP9 20010305 2191294 Mycobacterium leprae and [TNF] *induced* upregulation of MMP-2 and and increased secretion of these enzymes in cultured ST88-14 cells . Positive_regulation TNF MMP9 20333651 2266128 [TNF-alpha] *induces* expression in A549 cells : role of TNFR1/TRAF2/PKCalpha dependent signaling pathways . Positive_regulation TNF MMP9 20333651 2266160 Taken together , these data suggest that in A549 cells , [TNF-alpha] *induces* expression via the TNFR1/TRAF2/PKCalpha dependent JNK1/2/c-Jun and c-Src/EGFR/PI3K/Akt pathways . Positive_regulation TNF MMP9 20618688 2286565 Increase of [tumor necrosis factor-alpha] in the blood *induces* early activation of in the brain . Positive_regulation TNF MMP9 21473134 2413409 [TNF-alpha] may *induce* the expression of and promote the migration of eosinophil granulocyte . Positive_regulation TNF MMP9 21809585 2462567 The mechanism may include reducing [TNF-alpha] , IL-1beta content and *inhibiting* overexpression of in lung tissues . Positive_regulation TNF MMP9 22427508 2594294 Surprisingly , [TNF-a] strongly *induced* promoter activity in WT and CaMKIId ( -/- ) VSMC . Positive_regulation TNF MMP9 22676642 2638509 Inhibition of *suppressed* CCI induced mechanical allodynia and concomitant [TNF-a] and IL-17A expression in nerves . Positive_regulation TNF MMP9 23353699 2754227 Here , we demonstrated that in rat embryonic-heart derived H9c2 cells , [TNF-a] could *induce* mRNA expression associated with an increase in the secretion of MMP-9 , determined by real-time PCR , zymography , and promoter activity assays . Positive_regulation TNF MMP9 23427281 2887208 The [TNF-a] *induces* eNOS and expression and PKB activation . Positive_regulation TNF MMP9 23603294 2795169 The expression of MMP-1 , MMP-3 , and *increased* in the presence of [TNF-a] , and the addition of infliximab reversed the increase . Positive_regulation TNF MMP9 23774252 2843954 Understanding the regulation of expression and NADPH oxidase *activation* by [TNF-a] on H9c2 cells may provide potential therapeutic targets of chronic heart failure . Positive_regulation TNF MMP9 24361597 2911230 Here , we showed that in MC3T3-E1 cells , [TNF-a] *induced* gene expression determined by real-time PCR , zymography , and promoter assay . Positive_regulation TNF MMP9 24667088 2934885 In conclusion , transcriptional and translational activation of , downstream of p38 MAP kinase signaling , is *involved* in the ( [TNF-a] ) -induced loss of corneal endothelial barrier integrity . Positive_regulation TNF MMP9 8314909 220187 [TNF alpha] also *induced* the production of by TPA untreated U937 cells without morphological differentiation . Positive_regulation TNF MMP9 8892653 392140 [TNF-alpha] and IL-1beta selectively *induce* expression of <92-kDa gelatinase> by human macrophages . Positive_regulation TNF MMP9 9014820 405403 In support of this result , [TNF-alpha] stimulation *induced* membrane-type matrix metalloproteinase ( ) , a newly identified MMP-2-specific activator on synovial fibroblasts . Positive_regulation TNF MOCOS 21984710 2539613 In Exp. 1 ( n = 4 pigs ) , and mannan-rich fraction ( MRF ) , when added to AM cultures , were able to *increase* [TNF-a] production . Positive_regulation TNF MOCOS 22502799 2618340 Using SP-A ( -/- ) Kit ( W-sh/W-sh ) mice engrafted with TNF-a ( -/- ) or TNF receptor (TNF-R) ( -/- ) MCs , we found that [TNF-a] *activation* of through the TNF-R , but not MC-derived TNF-a , leads to augmented AHR during M pneumoniae infection when SP-A is absent . Positive_regulation TNF MOCOS 23882756 2821423 Besides , LP25-ACA *induced* the secretion of [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-6 (IL-6) from macrophages and dendritic cells showing the immunomodulatory effect of LP25 . Positive_regulation TNF MOK 18599158 2208586 We show here that : ( 1 ) S100B also stimulates AP-1 transcriptional activity in microglia via dependent activation of JNK; (2) S100B *upregulates* IL-1beta and [TNF-alpha] expression in microglia via RAGE engagement ; Positive_regulation TNF MOK 18599158 2208593 and ( 3 ) *induced* upregulation of COX-2 , IL-1beta and [TNF-alpha] expression requires the concurrent activation of NF-kappaB and AP-1 . Positive_regulation TNF MOK 8787669 380668 Induction of [tumor necrosis factor-alpha (TNF)] expression by MPs exposed to AGE-beta2M *resulted* from engagement of , as appearances of TNF transcripts and TNF antigen release into culture supernatants were prevented by addition of sRAGE , a process mediated , at least in part , by oxidant stress . Positive_regulation TNF MPG 1628418 191787 *induced* the synthesis of IL-1 beta , IL-6 and [TNF-alpha] with dose-responses and kinetics similar to those of Salmonella minnesota lipopolysaccharide ( Sm-Re-LPS ) . Positive_regulation TNF MPL 16394010 1506052 *enhanced* the secretion of [TNF-alpha] , but not that of IL-1beta , whereas Escherichia coli-type lipid A ( natural source derived and chemically synthesized lipid A ) enhanced the secretion of both cytokines . Positive_regulation TNF MPL 22191632 2543440 Meanwhile , compared with the control group , not only the mRNA expressions of [tumor necrosis factor-a (TNF-a)] , interleukin-6 (IL-6) , and interferon-? ( IFN-? ) in macrophages , but also the productions of proteins , were strongly *induced* by ; Positive_regulation TNF MPL 22829882 2635396 We also observed that *induced* high production of IL-2 , [TNF-a] , and IFN-? , in addition to IL-6 , IL-17 , and IL-10 . Positive_regulation TNF MPL 3135314 95788 These results suggest that the non-toxic as well as the toxic forms of lipid A can *induce* the production of [TNF] by macrophages . Positive_regulation TNF MPO 11509635 848630 The latter was accompanied by reduction in tissue expression and *suppressed* local [TNF-alpha] production . Positive_regulation TNF MPO 16490933 1528617 increased slightly at 4 and markedly at 9 weeks , and the [TNF-alpha] level *increased* at 11 weeks . Positive_regulation TNF MPO 19067146 2024072 The TNBS treatment caused colon shortening , increased activity , *induced* IL-1beta , [TNF-alpha] , and IL-6 expression in the colon , activated NF-kappaB , and potentiated the GAG degrading activities of intestinal microflora . Positive_regulation TNF MPO 20167660 2236399 Niacin also inhibited intima-media neutrophil recruitment and accumulation , enhanced endothelial dependent vasorelaxation and cyclic guanosine monophosphate production , increased vascular reduced glutathione content , and protected against hypochlorous acid induced endothelial dysfunction and [tumor necrosis factor] alpha *induced* vascular inflammation . Positive_regulation TNF MPO 9932719 589176 Myocardial ischaemia plus reperfusion in untreated rats produced marked myocardial necrosis , increased serum CPK activity and activity ( a marker of leukocyte accumulation ) both in the area-at-risk and in the necrotic area , reduced myocardial contractility and *induced* a marked increase in the serum levels of the [TNF-alpha] . Positive_regulation TNF MPP1 7822826 285665 Moreover , we found that antigenic [TNF alpha] levels in the *presence* of ( sTNF-R1 ) measured by different immunoassays were variable , depending on the immunoreagents and incubation time . Positive_regulation TNF MPP1 9551933 499117 We have examined the *roles* of and p75 in mediating and modulating the activity of [TNF] in vivo by generating and examining mice genetically deficient in these receptors . Positive_regulation TNF MPST 16362965 1597493 ( up to 100 mg/L ) exhibited only minor ( < 25 % suppression of succinate dehydrogenase ) cytotoxicity and did not *trigger* [TNFalpha] secretion nor modulate LPS induced TNFalpha secretion from monocytes . Positive_regulation TNF MPZ 18700057 2040976 The results showed that Ipt could decrease *induced* [TNF-alpha] release and p38 MAPK activation in reactive astrocytes . Positive_regulation TNF MRAP 15265899 1275511 ( 2 ) can *induce* [TNF-alpha] release from the J774 . Positive_regulation TNF MRXS5 17107518 1645100 Summarizing , [TNFalpha] *induces* both secretion from cultured porcine endometrium , but preferentially stimulates PGF ( 2alpha ) release from luminal epithelial cells . Positive_regulation TNF MRXS5 17192516 1709341 We examined whether and nitric oxide ( NO ) *mediate* [tumor necrosis factor (TNF)] actions in the estrus cycle . Positive_regulation TNF MS 7486863 332013 Genetic control of : *increased* production of lymphotoxin and [tumor necrosis factor-alpha] by HLA-DR2+ T cells . Positive_regulation TNF MS4A1 19384869 2069205 Stimulation of BM ( + ) B cells by CpG containing oligodeoxynucleotide enhanced expression of activation markers ( CD86 and CD54 ) *triggered* IL-6 and [TNF-alpha] secretion and cell proliferation . Positive_regulation TNF MSC 20429787 2307459 [TNF-alpha] released from papain treated lung cells *induces* to secret VEGF-A . Positive_regulation TNF MSH2 10477606 643232 Although activation of BMCMC induced the expression of mRNAs for the inflammatory cytokines IL-1beta , IL-4 , IL-6 , TNF-alpha , and the chemokine lymphotactin , mRNAs for IL-1beta , [TNF-alpha] , and lymphotactin were down modulated in the *presence* of . Positive_regulation TNF MSH2 16679696 1559504 alpha-MSH inhibited LPS induced [TNF-alpha] production , and simultaneously *augmented* production of interleukin (IL)-10 by PBMC . Positive_regulation TNF MSH3 10477606 643233 Although activation of BMCMC induced the expression of mRNAs for the inflammatory cytokines IL-1beta , IL-4 , IL-6 , TNF-alpha , and the chemokine lymphotactin , mRNAs for IL-1beta , [TNF-alpha] , and lymphotactin were down modulated in the *presence* of . Positive_regulation TNF MSH3 16679696 1559505 alpha-MSH inhibited LPS induced [TNF-alpha] production , and simultaneously *augmented* production of interleukin (IL)-10 by PBMC . Positive_regulation TNF MSH4 10477606 643234 Although activation of BMCMC induced the expression of mRNAs for the inflammatory cytokines IL-1beta , IL-4 , IL-6 , TNF-alpha , and the chemokine lymphotactin , mRNAs for IL-1beta , [TNF-alpha] , and lymphotactin were down modulated in the *presence* of . Positive_regulation TNF MSH4 16679696 1559506 alpha-MSH inhibited LPS induced [TNF-alpha] production , and simultaneously *augmented* production of interleukin (IL)-10 by PBMC . Positive_regulation TNF MSH5 10477606 643235 Although activation of BMCMC induced the expression of mRNAs for the inflammatory cytokines IL-1beta , IL-4 , IL-6 , TNF-alpha , and the chemokine lymphotactin , mRNAs for IL-1beta , [TNF-alpha] , and lymphotactin were down modulated in the *presence* of . Positive_regulation TNF MSH5 16679696 1559507 alpha-MSH inhibited LPS induced [TNF-alpha] production , and simultaneously *augmented* production of interleukin (IL)-10 by PBMC . Positive_regulation TNF MSH6 10477606 643236 Although activation of BMCMC induced the expression of mRNAs for the inflammatory cytokines IL-1beta , IL-4 , IL-6 , TNF-alpha , and the chemokine lymphotactin , mRNAs for IL-1beta , [TNF-alpha] , and lymphotactin were down modulated in the *presence* of . Positive_regulation TNF MSH6 16679696 1559508 alpha-MSH inhibited LPS induced [TNF-alpha] production , and simultaneously *augmented* production of interleukin (IL)-10 by PBMC . Positive_regulation TNF MST1 16289758 1560894 Interestingly , *induced* increase in IL-1 , [TNF-alpha] and IFN-gamma mRNA expression was evident in females , but not in males . Positive_regulation TNF MST1 16633352 1569481 Besides inducing interleukin-1 beta (IL-1beta) and interleukin-10 (IL-10) production , *triggers* an enhanced [tumor necrosis factor-alpha] release , especially in healthy and pulmonary fibrosis smokers . Positive_regulation TNF MSTN 19218333 2050176 In differentiated C2C12 cells , [TNF-alpha] *induced* the expression of through a p38MAPK dependent pathway involving nuclear factor kappa-B (NF-kappaB) . Positive_regulation TNF MSX2 20004646 2199816 In conclusion , our study suggests that [TNF-alpha] directly *induces* expression through the NF-kappaB pathway , which in turn induces expression of ALP , a key molecule in mineralization , in VSMCs . Positive_regulation TNF MSX2 20440096 2282726 Furthermore , [TNF-alpha] *induced* expression , and the knockdown of Msx2 by small interfering RNAs rescued ALP expression , which was inhibited by TNF-alpha . Positive_regulation TNF MT-ND1 11739521 886555 also *induced* high levels of [TNF-alpha] ( 900 pg/ml ) in human monocytes comparable to native SD flagellin ( 991.5 pg/ml ) and 6HIS flag ( 987 pg/ml ) . Positive_regulation TNF MT3 12061424 952851 In agreement , and BaP1 did not *induce* the synthesis of [TNF-alpha] by resident peritoneal macrophages in vitro . Positive_regulation TNF MTOR 11132130 760209 However , UV-B also induced expression of membrane bound [TNFalpha] , and this was *dependent* on signaling . Positive_regulation TNF MTOR 22025552 2508028 Targeted gene silencing of MyD88 ( short hairpin RNA ) and ( RNA interference ) inhibition *resulted* in TLR-4 mediated 70-kDa ribosomal protein S6 kinase activation and enhanced [TNF-a] release , whereas IL-10 release was inhibited in both silenced and nonsilenced HIV ( + ) macrophages . Positive_regulation TNF MTOR 22351078 2561123 The aim of this study was to investigate the *role* of in myocardial [TNF-a] expression during endotoxemia . Positive_regulation TNF MTOR 23094196 2690836 These findings suggest that NMDA induced [TNF] suppression can be *augmented* by concurrent inhibition . Positive_regulation TNF MTRF1 10339451 615848 *resulted* in increased expression of IL-1[alpha ] and [TNF[alpha] ] in AMs . Positive_regulation TNF MTTP 10815618 580205 LPS and ( liposome encapsulated N-acetyl-muramyl-L-alanyl-D-isoglutaminyl-L-alanine-2- : [ 1',2'dipalmitoyl -sni-glycero-3- ( hydroxy-phosphoryl-oxyl ) ] etylamide ) *induce* in liver macrophages a synthesis and release of [TNF-alpha] , nitric oxide and prostanoids . Positive_regulation TNF MTTP 10815618 580207 Inhibition of NF-kappaB inhibits the LPS- but not the *induced* release of [TNF-alpha] , nitric oxide and PGE2 . Positive_regulation TNF MTTP 10815618 580210 Exogenously added PGE2 inhibits the *activation* of map kinase and [TNF-alpha] release by LPS , but not by . Positive_regulation TNF MTTP 7650390 319332 LPS and liposome encapsulated *induce* liver macrophages cytotoxicity against tumor target cells and a release of [TNF-alpha] , nitric oxide , and eicosanoids but not a generation of superoxide anions . Positive_regulation TNF MTTP 8299114 248434 We have already reported that *induced* monocyte mediated tumoricidal activity and up-regulation of the [tumor necrosis factor] and interleukin-1 (IL-1) in vivo and in vitro . Positive_regulation TNF MTTP 9698520 524940 *increased* bioactive [TNF-alpha] response to EC ( MTP + EC vs EC controls : 685 +/- 255 U/ml vs 250 +/- 180 U/ml , P < 0.02 ) . Positive_regulation TNF MTX1 10614715 575721 + EtOH *increased* the release of IL 6 , IL 8 and [TNF alpha] by 1.0 , 1.2 , and 1.1 times , respectively . Positive_regulation TNF MTX1 21194185 2373900 Neither nor BSO *had* an effect on the mRNA expressions of IL-4 , transforming growth factor ß ( TGF-ß ) , and [tumor necrosis factor-a (TNF-a)] in the spleen . Positive_regulation TNF MTX1 23963446 2845512 *increased* the mRNA levels of [TNF-a] , IL-1ß , MIP-2 , and TLR4 in the small intestine , as well as the protein expression of claudin-2 . Positive_regulation TNF MTX1 9278181 450832 GSTM and *augmented* spontaneous [TNF alpha] production in normal individuals and patients with RA but did not influence LPS stimulated TNF alpha production . Positive_regulation TNF MUC1 15477874 1380437 Furthermore , IFN-gamma and [TNF-alpha] strongly *induce* expression in both normal prostate epithelia and certain prostate tumor cell lines and may exacerbate pathologies associated with MUC1 positive prostate cancers . Positive_regulation TNF MUC1 17575006 1786099 [TNF-alpha] *induces* gene transcription in lung epithelial cells : its signaling pathway and biological implication . Positive_regulation TNF MUC1 17575006 1786110 We conclude that [TNF-alpha] *induces* gene transcription through a TNFR1 -- > MEK1/2 -- > ERK1 -- > Sp1 pathway . Positive_regulation TNF MUC1 18436821 1900339 [TNF] *induced* the release of , MUC4 , and MUC16 from the HCLE surface . Positive_regulation TNF MUC1 20448050 2381088 These results suggest that the up-regulation of during airway PA infection might be crucial for suppressing excessive and prolonged inflammatory responses , and is *induced* mainly by [TNF-a] , the key proinflammatory mediator . Positive_regulation TNF MUC1 22021035 2513644 ChIP and real-time PCR experiments revealed that *up-regulated* IL-6 and [TNF-a] expression by binding to their promoter regions in a NF-?B p65 dependent manner in both MUC1 transfected and human breast cancer cells that express endogenous MUC1 . Positive_regulation TNF MUC1 24282280 2898683 RNA interference mediated attenuation of MUC1 suppressed CSE induced secretion of TNF-a from macrophages , by suppressing the activity of the TNF-a converting enzyme ( TACE ) , arguing that is *required* for CSE induced and TACE mediated [TNF-a] secretion . Positive_regulation TNF MUC1 24282280 2898684 Similarly , blockade after CSE induction through suppression of PPAR-? or ERK *inhibited* TACE activity and [TNF-a] secretion . Positive_regulation TNF MUC1 7536782 300303 In contrast with J774.1 cells and thioglycolate medium elicited macrophages ( T-PEM ) , exhibited serum independent TNF-alpha production , and a polyclonal Ab to murine CD14 *had* no inhibitory effect on the LPS induced [TNF-alpha] production by P-PEM . Positive_regulation TNF MUC16 18436821 1900338 [TNF] *induced* the release of MUC1 , MUC4 , and from the HCLE surface . Positive_regulation TNF MUC16 20036239 2205208 Combined treatment with TNF-alpha and IFN-gamma showed effects similar to IFN-gamma alone , except that ectodomain release followed that of [TNF-alpha] , which *induced* ectodomain release . Positive_regulation TNF MUC2 18507686 1958431 [TNF-alpha] *induced* the expression of CDX2 and in cultured BEC . Positive_regulation TNF MUC2 20062084 2225433 These differences can be attributed to specific cytokines , because [TNF-alpha] and IL-1beta *induced* but no MUC4 expression in gastric cancer cell lines . Positive_regulation TNF MUC4 18436821 1900340 [TNF] *induced* the release of MUC1 , , and MUC16 from the HCLE surface . Positive_regulation TNF MUC4 20062084 2225434 These differences can be attributed to specific cytokines , because [TNF-alpha] and IL-1beta *induced* MUC2 but no expression in gastric cancer cell lines . Positive_regulation TNF MUC5AC 12690113 1099948 Interleukin-1 beta and [tumor necrosis factor-alpha] *induce* overexpression through a mechanism involving ERK/p38 mitogen activated protein kinases-MSK1-CREB activation in human airway epithelial cells . Positive_regulation TNF MUC5AC 12690113 1099952 However , the mechanisms by which the interleukin (IL)-1beta and [tumor necrosis factor (TNF)-alpha] *induce* gene expression in normal nasal epithelial cells , and the signal molecules involved , especially in the downstream signaling of mitogen activated protein ( MAP ) kinases , remain unclear . Positive_regulation TNF MUC5AC 15266025 1275942 We also observed that [tumor necrosis factor (TNF)-alpha] , platelet activating factor (PAF) , and lipopolysaccharide (LPS) *induced* COX-2 and increased production that was blocked by celecoxib , suggesting a common signaling pathway of inflammatory mediator induced MUC5AC production in NHTBE cells . Positive_regulation TNF MUC5AC 15513533 1328324 [TNF-alpha] *induced* gene expression , and ERK activation was found to be essential for TNF-alpha induced MUC5AC gene expression in cultured human nasal polyp epithelial cells . Positive_regulation TNF MUC5AC 15513533 1328326 [TNF-alpha] *induces* gene expression via ERK in cultured human nasal polyp epithelial cells . Positive_regulation TNF MUC5AC 15864435 1401346 [TNF-alpha] *induced* expression of hST3GalIV , FUT3 , C2/4GnT and mRNAs in NCI-H292 cells . Positive_regulation TNF MYC 16924232 1692187 [TNF] *induced* the expression of NF-kappaB regulated gene products cyclin D1 , , matrix metalloproteinase-9 , survivin , X-linked inhibitor-of-apoptosis protein ( IAP ) , IAP1 , Bcl-x ( L ) , A1/Bfl-1 and Fas associated death domain protein-like IL-1beta converting enzyme-inhibitory protein in wild-type MEF but not in PKR-/- cells . Positive_regulation TNF MYC 23553791 2804125 More interestingly , a long-term elevated levels of IFN-? and [TNF-a] *result* in significantly increased susceptibility to malignant transformation in MSCs through NF?B mediated upregulation of the oncogenes c-Fos and Depletion of either IFN-? or TNF-a in OVX mice abolishes MSC impairment and the tendency toward malignant transformation with no NF?B mediated oncogene activation . Positive_regulation TNF MYD88 12139759 969325 is *involved* in the signalling pathway for Taxol induced apoptosis and [TNF-alpha] expression in human myelomonocytic cells . Positive_regulation TNF MYD88 12244183 990581 Furthermore , MyD88-deficient , but not IFN-gamma-deficient , Kupffer cells could not produce TNF-alpha in response to LM in vitro , indicating the importance of *dependent* [TNF-alpha] production for host defense . Positive_regulation TNF MYD88 12244183 990583 These results indicated a critical role for *dependent* [IL-12/TNF-alpha] production and for IL-12- and IL-18 mediated IFN-gamma production in early phase clearance of LM . Positive_regulation TNF MYD88 12874236 1114975 Our results show that HKBA mediated induction of IL-12p40 and [TNF] is *dependent* on the adapter molecule . Positive_regulation TNF MYD88 14630816 1210104 In contrast , in macrophages neither , Mal/TIRAP , nor I kappa B kinase 2 (IKK2) are *required* for NF-kappa B activation or [tumor necrosis factor alpha (TNF alpha)] , IL-6 , or IL-8 production , although Mal/TIRAP is still involved in the production of interferon beta (IFN beta) . Positive_regulation TNF MYD88 14977922 1213306 *Role* of in diminished [tumor necrosis factor] alpha production by newborn mononuclear cells in response to lipopolysaccharide . Positive_regulation TNF MYD88 15898987 1408681 These findings indicate that the production of [TNF-alpha] and IL-13 by LPS *required* signalling as a common pathway of mast cell mediated inflammation . Positive_regulation TNF MYD88 16491077 1535134 Here we demonstrate that *increased* the half-life but not the synthesis of IFN-gamma induced mRNA transcripts encoding [tumor necrosis factor] and IFN-gamma-inducible protein 10 . Positive_regulation TNF MYD88 16825490 1632016 We determined that mitogen activated protein kinase (MAPK) activation and [tumor necrosis factor-alpha (TNF-alpha)] production in macrophage infected with Mycobacterium avium or M smegmatis is *dependent* on myeloid differentiation factor 88 ( ) and TLR2 but not TLR4 , MR , or CR3 . Positive_regulation TNF MYD88 16936244 1673100 [TNF] induction *required* and was absent in TLR2/4 ( -/- ) cells in response to fliC but not wild-type P. aeruginosa , whereas TLR2 ( -/- ) cells exhibited augmented responses . Positive_regulation TNF MYD88 17255320 1691068 In addition , overexpression of dominant negative forms of and Mal/TIRAP significantly *down-regulated* the spontaneous production of cytokines [tumor necrosis factor-alpha] , IL-6 , and vascular endothelial growth factor , and enzymes MMP-1 , MMP-2 , MMP-3 , and MMP-13 in RA synovial membrane cell cultures . Positive_regulation TNF MYD88 18691413 1955419 TLR adaptor molecule strongly *regulated* [TNF-alpha] production in response to heat killed B. pseudomallei . Positive_regulation TNF MYD88 19004989 2029005 These data , combined with the strict MyD88 dependent production of TNF in Salmonella infected mice , suggest that *dependent* [TNF] mediates DC death . Positive_regulation TNF MYD88 19294383 2119987 Downregulation of and TLR4 expression using small interfering RNA ( siRNA ) significantly *inhibited* gamma-PGA induced [TNF-alpha] secretion from the RAW264.7 cells . Positive_regulation TNF MYD88 19539649 2103606 IL-12 and [TNF-alpha] production by dendritic cells stimulated with Schistosoma mansoni schistosomula tegument is TLR4- and *dependent* . Positive_regulation TNF MYD88 19570869 2122083 In contrast , iPPVO induced [TNF-alpha] release and enhanced expression of MHC-I and CD86 but not of MHC-II by BMDC chiefly *requires* but not TLR2 or TLR4 . Positive_regulation TNF MYD88 19783673 2147626 In macrophages prestimulated with IFN-gamma , sHz also results in a *dependent* release of [TNF-alpha] . Positive_regulation TNF MYD88 19797072 2159390 In macrophages , TLR4 and the adaptor molecule , but not TLR2 or TLR5 , are *required* for [tumor necrosis factor] alpha production induced by B. thailandensis . Positive_regulation TNF MYD88 19950169 2204017 Unexpectedly , BM-derived DC from PKC-alpha ( -/- ) mice exhibited decreased [TNF-alpha] and IL-12p40 production *induced* by both and TRIF dependent ligands . Positive_regulation TNF MYD88 20019195 2200158 Absence of *resulted* in diminished production of inflammatory cytokines such as interleukin-12 , interferon-gamma , and [tumor necrosis factor-alpha] as well as chemoattractants such as monocyte chemotactic protein-1 (MCP-1) and Keratinocyte derived chemokine ( KC ) , and hampered recruitment of effector cells involved in bacterial clearance ( macrophages and neutrophils ) to the infection site . Positive_regulation TNF MYD88 20699281 2479915 Our results indicated that elevated [tumor necrosis factor-a] , interferon-? , interleukin (IL)-1a/ß and IL-6 production from mouse spleen cells treated with SEB alone or in combination with lipopolysaccharide (LPS) was *regulated* by . Positive_regulation TNF MYD88 20954191 2369337 Stimulation of [TNF] by cFb was *dependent* on TLR-4 and , while stimulation by cFb-IC was dependent on both TLR-4/MyD88 and Fc?R . Positive_regulation TNF MYD88 21182083 2373737 Analysis of upstream signaling events revealed that TLR 2/4 mediated *dependent* participation of IL-1R activated kinase (IRAK)1 , [TNF receptor associated factor (TRAF)6] and TGFß activated kinase (TAK)1 is essential to induce cystatin mediated I?B kinase ( IKK ) /NF-?B activation in macrophages . Positive_regulation TNF MYD88 22025552 2508029 Targeted gene silencing of ( short hairpin RNA ) and mTOR ( RNA interference ) inhibition *resulted* in TLR-4 mediated 70-kDa ribosomal protein S6 kinase activation and enhanced [TNF-a] release , whereas IL-10 release was inhibited in both silenced and nonsilenced HIV ( + ) macrophages . Positive_regulation TNF MYD88 22051147 2527814 Moreover , the joint production of [TNF-a] , IL-1ß and CXCL1/KC by zymosan was *dependent* on signaling . Positive_regulation TNF MYD88 22075930 2540666 Macrophage elicited osteoclastogenesis in response to Brucella abortus infection requires *dependent* [TNF-a] production . Positive_regulation TNF MYD88 22116836 2529929 signals *increased* levels of interferon ( IFN ) ß and [tumor necrosis factor (TNF)] a transcripts in the brains of infected mice and both TNF-a and IFN-a/ß , receptors promoted T-cell and trypanosoma infiltration into the brain parenchyma . Positive_regulation TNF MYD88 22262768 2564511 Heme induced cell death required TNFR1 and *dependent* [TNF] production . Positive_regulation TNF MYD88 22262768 2564515 Taken together , these results revealed that heme induces macrophage necrosis through 2 synergistic mechanisms : *dependent* expression of [TNF] and TLR4 independent generation of ROS . Positive_regulation TNF MYD88 25015829 2952964 We observed that p120 inhibited *dependent* NF-?B activation and release of [TNF-a] and IL-6 , but enhanced TIR domain containing adapter inducing IFN-ß dependent IFN regulatory factor 3 activation and release of IFN-ß upon LPS exposure . Positive_regulation TNF MYL1 17476691 1772264 [TNF-alpha] rapidly *induced* RhoA activation and phosphorylation , but caused only small changes to cortical F-actin , without significantly increasing paracellular permeability up to 30 min after stimulation . Positive_regulation TNF MYL10 17476691 1772262 [TNF-alpha] rapidly *induced* RhoA activation and phosphorylation , but caused only small changes to cortical F-actin , without significantly increasing paracellular permeability up to 30 min after stimulation . Positive_regulation TNF MYL2 11384975 842392 Changes in the activation of caspase-8 that parallel changes in regulatory light chain phosphorylation levels reveal that motor activities *regulate* [TNF receptor-1 (TNFR-1)] signaling at an early step in the TNF death signaling pathway . Positive_regulation TNF MYL2 17476691 1772265 [TNF-alpha] rapidly *induced* RhoA activation and phosphorylation , but caused only small changes to cortical F-actin , without significantly increasing paracellular permeability up to 30 min after stimulation . Positive_regulation TNF MYL3 17476691 1772266 [TNF-alpha] rapidly *induced* RhoA activation and phosphorylation , but caused only small changes to cortical F-actin , without significantly increasing paracellular permeability up to 30 min after stimulation . Positive_regulation TNF MYL4 10574921 569205 Similar to gangliosides , *induced* production of NO and [TNF-alpha] and expression of COX-2 . Positive_regulation TNF MYL4 17476691 1772267 [TNF-alpha] rapidly *induced* RhoA activation and phosphorylation , but caused only small changes to cortical F-actin , without significantly increasing paracellular permeability up to 30 min after stimulation . Positive_regulation TNF MYL5 17476691 1772268 [TNF-alpha] rapidly *induced* RhoA activation and phosphorylation , but caused only small changes to cortical F-actin , without significantly increasing paracellular permeability up to 30 min after stimulation . Positive_regulation TNF MYL6 17476691 1772269 [TNF-alpha] rapidly *induced* RhoA activation and phosphorylation , but caused only small changes to cortical F-actin , without significantly increasing paracellular permeability up to 30 min after stimulation . Positive_regulation TNF MYL7 17476691 1772261 [TNF-alpha] rapidly *induced* RhoA activation and phosphorylation , but caused only small changes to cortical F-actin , without significantly increasing paracellular permeability up to 30 min after stimulation . Positive_regulation TNF MYL9 17476691 1772260 [TNF-alpha] rapidly *induced* RhoA activation and phosphorylation , but caused only small changes to cortical F-actin , without significantly increasing paracellular permeability up to 30 min after stimulation . Positive_regulation TNF MYLIP 20086228 2226049 We found that IL-1beta and [TNF-alpha] *induce* the expression of , miR-34a , and miR-146a both in MIN6 cells and human pancreatic islets . Positive_regulation TNF MYLIP 20195282 2281468 In addition , this study also provided evidence that treatment in vitro could *induce* the protein expression of [TNF-alpha] , MCP-1 , NF-kappaB p65 , which are key pro-inflammatory cytokines and critical transcription factor in AS . Positive_regulation TNF MYLIP 20435889 2274758 Functional inhibition of *prevented* [TNFalpha] mRNA degradation , and blocking miR-579 and miR-125b precluded translation arrest . Positive_regulation TNF MYLIP 21947847 2562388 Furthermore , overexpression of reduced H. pylori *induced* IL-8 , [TNF-a] , and IL-1ß . Positive_regulation TNF MYLIP 22499991 2595582 In mice with diabetes mellitus , excessive [tumor necrosis factor-a] *induced* blunting proangiogenic functions of GATA2 and VEGFR2 . Positive_regulation TNF MYLIP 22518321 2584523 Induction of *contributed* to increased [TNF alpha] production and to the sensitization of KCs to produce more TNF alpha in response to LPS . Positive_regulation TNF MYLIP 22581933 2619522 Transfection of the miR-125b precursor into neonatal monocytes significantly repressed the TNF-a mRNA and protein expression , suggesting that negatively *regulates* [TNF-a] expression in neonatal monocytes . Positive_regulation TNF MYLIP 22634176 2638260 Furthermore , expression could be *induced* by [TNF-a] through the JNK pathway . Positive_regulation TNF MYLIP 22950459 2693382 Our data suggest a potential *role* for in the regulation of [TNF-a] expression after ischemia/hypoxia and microglia mediated neuronal injury . Positive_regulation TNF MYLIP 23613494 2790317 Meanwhile , lentiviral overexpression of *inhibited* neuronal apoptosis and microglia activation , including suppressing ionized calcium binding adaptor molecule-1 immunoreactivity and protein level , and reduced [tumor necrosis factor-a] production . Positive_regulation TNF MYLIP 23650073 2800704 Knockdown of miR-181 *enhanced* LPS induced production of pro-inflammatory cytokines ( [TNF-a] , IL-6 , IL-1ß , IL-8 ) and HMGB1 , while overexpression of resulted in a significant increase in the expression of the anti-inflammatory cytokine IL-10 . Positive_regulation TNF MYLIP 23795660 2802760 Further , we observed that directly *regulated* [TNF-a] expression because miR-19a can suppress the expression of wild-type TNF-a reporter , but not the mutant form . Positive_regulation TNF MYLIP 23795660 2802762 Taken together , this study determines the levels of miR-19a and TNF-a in both DSS induced experimental murine colitis and human UC and further demonstrates that might directly *regulate* [TNF-a] . Positive_regulation TNF MYLIP 24098322 2852213 Overexpression of accelerated accumulation of lipid droplets , increased the amount of triglycerides , and *repressed* [TNF-a] protein expression , while the inhibitor had the opposite effect . Positive_regulation TNF MYLIP 24442429 2912802 The *role* of in regulation of induction of [TNF-a] was confirmed by transfecting cells with an inhibitor and a mimic of miR-146a . Positive_regulation TNF MYLIP 24670381 2938587 Overexpression of significantly *suppressed* the production of IL-8 , CCL20 , and [tumor necrosis factor-a] , which functionally suppressed the chemotactic attraction of neutrophils by keratinocytes . Positive_regulation TNF MYLK 12631580 1067743 [TNF-alpha] *induced* the caspase dependent cleavage of EC in transfected endothelial cells , which was confirmed by mass spectroscopy with in vitro cleavage by caspase 3 at LKKD ( D1703 ) . Positive_regulation TNF MYLK 15701621 1372567 The cycloheximide inhibition of protein expression *prevented* the [TNF-alpha] increase in MLCK activity and Caco-2 TJ permeability . Positive_regulation TNF MYLK 15701621 1372568 Moreover , inhibitors of , Mg ( 2+ ) -myosin ATPase , and metabolic energy *prevented* the [TNF-alpha] increase in Caco-2 TJ permeability , suggesting that the increase in MLCK activity was required for the TNF-alpha induced opening of the Caco-2 TJ barrier . Positive_regulation TNF MYLK 15701621 1372571 In conclusion , our results indicate for the first time that 1 ) the [TNF-alpha] increase in Caco-2 TJ permeability was *mediated* by an increase in protein expression , 2 ) the increase in MLCK protein expression was regulated by an increase in MLCK mRNA transcription , and 3 ) the increase in Caco-2 TJ permeability required MLCK protein expression dependent increase in MLCK activity . Positive_regulation TNF MYLK 18363837 1957966 Previous studies have shown that [TNF-alpha] increase in TJ permeability was *regulated* by an increase in gene activity and protein expression . Positive_regulation TNF MYLK 8263039 239245 [TNF] activation of DNA fragmentation was *blocked* by a potent inhibitor of but was unaffected by inhibitors of cAMP or cGMP dependent PKs . Positive_regulation TNF MYO10 17642135 1669015 Chlamydia pneumoniae (Chp) causes chronic myocyte infection , affects apoptosis and [TNF-alpha] production , and may *induce* cross reactivity with alpha . Positive_regulation TNF MYO16 17642135 1669014 Chlamydia pneumoniae (Chp) causes chronic myocyte infection , affects apoptosis and [TNF-alpha] production , and may *induce* cross reactivity with alpha . Positive_regulation TNF MYO19 17642135 1669013 Chlamydia pneumoniae (Chp) causes chronic myocyte infection , affects apoptosis and [TNF-alpha] production , and may *induce* cross reactivity with alpha . Positive_regulation TNF MYO6 17642135 1669016 Chlamydia pneumoniae (Chp) causes chronic myocyte infection , affects apoptosis and [TNF-alpha] production , and may *induce* cross reactivity with alpha . Positive_regulation TNF NA 11697119 877547 Adherence to tissues and chemotaxis ( the earliest two functions of lymphocytes in the immune response ) , as well as ROS levels and [TNF alpha] production were determined in the *presence* or absence of or AA ( 0.001 , 0.01 , 0.1 , 1 and 2.5 mM ) in lymphocytes from peritoneum , axillary nodes , spleen and thymus obtained at several times ( 2 , 4 , 12 and 24 hours ) after LPS injection . Positive_regulation TNF NA 19050604 2017532 Dx , administered before or after AP , and reduced the leukocytosis induced by AP and *blocked* the ability of circulating monocytes to produce [tumor necrosis factor-alpha] and monocyte chemoattractant protein-1 ; Positive_regulation TNF NA 19575001 2104775 NAC treatment also decreased the pulmonary protein content at 48 and 72 h and the lung wet/dry weight ratio at 24 and 48 h. Additionally , *enhanced* pulmonary production of [TNF-alpha] and IL-10 at 24 h and 48 h . Positive_regulation TNF NA 9242544 446078 Our data show that ( 1 ) *induces* an early and sustained increase of membrane [tumor necrosis factor alpha (TNF alpha)] expression on human stimulated-peripheral blood (PB) T cells and ( 2 ) increases membrane TNF-RI and TNF-RII on tumoral cell lines and on T cells after stimulation . Positive_regulation TNF NAALADL1 11435497 832572 The PKC inhibitor H7 reduced LTA dependent secretion of TNF-alpha by 94 % but inhibited poly *dependent* [TNF-alpha] production only by 50 % . Positive_regulation TNF NAALADL1 15538753 1355179 We show that innate signals LPS- and poly *lead* to stronger upregulation of TLRs and production of the cytokines IL-6 and [TNF-alpha] as well as innate immune effector molecules IFN-alpha4 , IFN-beta , and iNOS compared with cytokine stimulated astrocytes . Positive_regulation TNF NAALADL1 15683451 1370617 The lymph node homing chemokine receptor CCR-7 expression was induced by [TNF-alpha] + IL-1beta + IL-6 + prostaglandin E2 but was not *induced* by Poly + TNF-alpha . Positive_regulation TNF NAALADL1 17267173 1718159 In naïve mice , poly ( 2mg/kg ) modestly *increased* sickness behaviors , plasma IL-6 , [TNF-alpha] and IL-10 levels , but did not affect IL-1 , IL-4 , or IFN-gamma . Positive_regulation TNF NAALADL1 18055568 1867369 Similarly , SCM attenuated poly *induced* [TNF-alpha] production by PBMC and NK cells . Positive_regulation TNF NAALADL1 19761760 2147364 The dsRNA-mimetic poly ( ) and IL-18 *synergize* for IFNgamma and [TNFalpha] expression . Positive_regulation TNF NAALADL1 20655404 2322158 However , geniposide did not decrease [TNF-a] release *induced* by CpG DNA , Poly or IL-1ß . Positive_regulation TNF NAALADL1 21968540 2525943 Interferon-beta , but not [tumor necrosis factor-alpha] , production in *response* to poly is maintained despite exhaustive exercise in mice . Positive_regulation TNF NAALADL1 21968540 2525947 Although [TNF-a] in *response* to poly was significantly inhibited by exhaustive exercise , IFN-ß was no different in both groups . Positive_regulation TNF NAALADL1 21968540 2525949 In in-vitro experiments , catecholamines inhibited poly *induced* [TNF-a] , but not IFN-ß , production in macrophages . Positive_regulation TNF NAALADL1 24089189 2863460 For CD4 T cells , combining poly and ISCOMs *increased* the frequency of multifunctional cells , producing IFN-? , IL-2 , and [TNF] , and the total magnitude of the response compared with either adjuvant alone . Positive_regulation TNF NAIP 25149528 2957416 MAVS , caspase1 , IL-18 , and [TNF-a] showed increases in expression in AH compared to the controls ( p < 0.05 ) , and expression markedly *increased* in AH compared to the controls ( p < 0.01 ) . Positive_regulation TNF NAMPT 17237424 1690065 In CD14 ( + ) monocytes , *induces* the production of IL-1beta , [TNF-alpha] , and especially IL-6 . Positive_regulation TNF NAMPT 18493620 1917327 Moreover , inhibition *reduced* intracellular NAD concentration in inflammatory cells and circulating [TNFalpha] levels during endotoxemia in mice . Positive_regulation TNF NANOS2 12427659 1014765 Myocardial [tumor necrosis factor] , interleukin-1beta (IL-1beta) , and *induction* was measured before and 6 hours after LPS challenge . Positive_regulation TNF NANOS2 17588258 1786269 Furthermore , [TNF-alpha] and LPS significantly *induced* expression . Positive_regulation TNF NANOS2 21926986 2497363 Expression of and production of nitric oxide paralleled the activation of T cells and *required* a tripartite synergism of interferon-? , [tumor necrosis factor] and direct contact with activated T cells . Positive_regulation TNF NANOS2 7544539 318315 We conclude that 1 ) [TNF-alpha] and IFN-gamma *induce* the expression of vascular smooth muscle and production of NO in RMIC , and 2 ) NO acts as an autocrine activator of the soluble guanylyl cyclase in RMIC . Positive_regulation TNF NANOS2 8700134 375437 activity was *induced* by lipopolysaccharide , IL-1 beta , [TNF alpha] , and IFN gamma but not by IL-6 . Positive_regulation TNF NANOS2 9419012 472316 These results imply that cytokine activated astrocytes release [TNF alpha] which can *induce* expression in endothelium and suggest that activated astrocytes within the CNS may induce expression of NOS-2 in cells of the adjacent microvasculature . Positive_regulation TNF NCF1 14530365 1149347 Only [TNF-alpha] and GM-CSF *induced* a clear phosphorylation . Positive_regulation TNF NCF1 15743827 1379083 Acute [tumor necrosis factor] alpha signaling via NADPH oxidase in microvascular endothelial cells : *role* of phosphorylation and binding to TRAF4 . Positive_regulation TNF NCF1 15743827 1379096 Thus , both phosphorylation and TRAF4 are *required* for acute [TNF-alpha] signaling . Positive_regulation TNF NCF1 16527821 1568056 ROS production was the result of [TNFalpha] *activation* of Ser phosphorylation of NADPH oxidase subunit and its translocation to EC membranes . Positive_regulation TNF NCF1 17197441 1702257 Additionally , [TNF-alpha] *induced* the association of CD11b/CD18 with the NADPH oxidase subunit Nox2 ( gp91(phox) ) and phosphorylation of , indicating the CD11b/CD18 dependence of NADPH oxidase activation . Positive_regulation TNF NCF1 23639811 2805070 In vivo , c-Src-KO mice also had impaired TNF-a and NF-?B responses following partial lobar liver I/R. Studies in NOX1 and p47phox knockout primary hepatocytes demonstrated that both NOX1 and are partially *required* for H/R mediated [TNF-a] production . Positive_regulation TNF NCL 19060367 2000031 [ *Role* of cell-surface in lipopolysaccharide stimulated expression and secretion of [TNF-alpha] and IL-1beta ] . Positive_regulation TNF NCL 19060367 2000037 To explore the *role* of cell-surface in lipopolysaccharide (LPS) stimulated expression and secretion of [TNF-alpha] and IL-1beta in human THP-1 monocytes . Positive_regulation TNF NCR1 18713971 1950756 We finally found that in dNK , mAb-specific engagement of NKp30 , but not , *triggered* the production of IFN-gamma , [TNF-alpha] , MIP-1alpha , MIP-1beta , and GM-CSF proinflammatory molecules . Positive_regulation TNF NCR1 22457623 2578425 Finally , we show in vitro that the interaction of NK cells with F. nucleatum leads to an *dependent* secretion of [TNF-a] . Positive_regulation TNF NCR3 18713971 1950755 We finally found that in dNK , mAb-specific engagement of , but not NKp46 , *triggered* the production of IFN-gamma , [TNF-alpha] , MIP-1alpha , MIP-1beta , and GM-CSF proinflammatory molecules . Positive_regulation TNF NCR3 21552268 2440784 In a retrospective analysis of 80 individuals with GIST , predominant expression of the immunosuppressive NKp30c isoform ( over the immunostimulatory NKp30a and NKp30b isoforms ) was associated with reduced survival of subjects , decreased *dependent* [tumor necrosis factor-a (TNF-a)] and CD107a release , and defective interferon-? ( IFN-? ) and interleukin-12 (IL-12) secretion in the NK-DC cross-talk that could be restored by blocking of IL-10 . Positive_regulation TNF NEDD9 19531803 2098820 We showed a specific role for A kinase anchoring protein 95 in suppressing the expression of the gene encoding [tumor necrosis factor-alpha] , which *involved* phosphorylation of ( also known as Nfkb1 ) by PKA at a site adjacent to the region targeted by inhibitor of nuclear factor kappaB kinases . Positive_regulation TNF NELFCD 12449171 1018249 In order to determine whether [TNF-alpha] release was *triggered* by T-cell activation by Be stimulation in the context of HLA-DPGlu69 molecules , the proliferation of BeSO4 stimulated blood mononuclear cells and the release of IFN-gamma , TNF-alpha , RANTES ( regulated on activation normal T-cell expressed and secreted ) , granulocyte-macrophage colony stimulating factor , interleukin (IL)-4 , IL-6 , IL-8 , IL-10 and IL-12 by BeSO4 stimulated blood mononuclear cells was quantified in 11 individuals with berylliosis using an anti-HLA-DP antibody as a probe for HLA-DP restricted T-cell activation . Positive_regulation TNF NELFCD 16799336 1579263 Subcutaneously injected [TNF/DC] *induce* an unpolarized ( H ) 2 response and are not protective in the experimental autoimmune encephalomyelitis model . Positive_regulation TNF NELFCD 20153259 2248506 Using PBMC from healthy individuals , we show that monocytes differentiated with IL-15 ( IL15-DC ) produced IL-1beta , IL-6 , IL-15 , IL-23 , [TNFalpha] and CCL20 in *response* to pepsin-trypsin digested gliadin (PTG) and activated contact dependent Th17 and responses from autologous CD4 ( + ) T cells . Positive_regulation TNF NELFCD 9916686 587475 Based on previous work that suggests that the production of IL-12 by activated human central nervous system derived microglia is regulated by autocrine TNF-alpha , we wanted to determine whether inhibition of [TNF] could *induce* a reduction of responses by its impact on systemic APCs . Positive_regulation TNF NF1 8939900 398540 Here , we report that binding sites for the transcription factor *mediate* antagonistic TGF-beta and [TNF-alpha] transcriptional regulation in NIH3T3 fibroblasts . Positive_regulation TNF NFAT5 11485737 844900 Using dominant negative proteins that inhibit NFAT5 dimerization , we show that *regulates* expression of the [TNFalpha] and lymphotoxin-beta genes in osmotically stressed T cells . Positive_regulation TNF NFAT5 22312110 2552448 was essential for the induction of the key antimicrobial gene Nos2 ( inducible nitric oxide synthase [ iNOS ] ) in response to low and high doses of TLR agonists but is *required* for [Tnf] and Il6 mainly under mild stimulatory conditions , indicating that NFAT5 could regulate specific gene patterns depending on pathogen burden intensity . Positive_regulation TNF NFATC1 17485464 1750565 We report that RANKL and [TNF] can *induce* osteoclast formation directly from NF-kappaB p50/p52 double knockout ( dKO ) osteoclast precursors when either c-Fos or is expressed . Positive_regulation TNF NFATC1 18097033 1847478 Ectopic expression of NFATc2 but not , especially its short isoform , *enhanced* [TNF-alpha] synthesis in human T cells at the gene transcription level , whereas both NFATs augmented IL-2 expression . Positive_regulation TNF NFATC2 10952728 762562 These results demonstrate that is an essential *activator* of immediate early [TNF-alpha] gene expression in T cells and they present in vivo evidence of the inducer- and cell type-specific regulation of TNF-alpha gene expression . Positive_regulation TNF NFATC2 18097033 1847479 Ectopic expression of but not NFATc1 , especially its short isoform , *enhanced* [TNF-alpha] synthesis in human T cells at the gene transcription level , whereas both NFATs augmented IL-2 expression . Positive_regulation TNF NFATC2 19060202 2001756 We also show that these NFATp subdomains interact with the coactivator CBP ( CREB binding protein ) , which is required for *dependent* [TNF] gene transcription . Positive_regulation TNF NFATC2 22844476 2635711 These results thus demonstrate that NFATp plays a critical role in immune containment of TB disease in vivo , through the *dependent* expression of [TNF] and IFN-? in T cells . Positive_regulation TNF NFATC2 7982959 281700 The *role* of in cyclosporin A-sensitive [tumor necrosis factor-alpha] gene transcription . Positive_regulation TNF NFATC2 8552071 347102 [Tumor necrosis factor] alpha gene regulation in activated T cells *involves* ATF-2/Jun and . Positive_regulation TNF NFATC2 8816436 383620 In A20 B cells , the [TNF-alpha] gene is not *regulated* by bound to the kappa 3 element . Positive_regulation TNF NFATC4 17522069 1797981 This conclusion was based on the findings that inhibition of activation by either FK506 or NFAT3 siRNA dramatically *down-regulated* the [TNF] induction upon B [ a ] PDE exposure , and that knock-down of TNF by its specific siRNA also led to abrogation of B [ a ] PDE induced cell transformation in Cl41 cells and their tumorigenicity in nude mice . Positive_regulation TNF NFE2L2 21670314 2451214 We found that in monocytes [TNF] *induces* sustained activation and Nrf2 cytoprotective gene induction in a TNFR1 dependent manner . Positive_regulation TNF NFE2L3 15388789 1354229 Furthermore , we showed that transcript and protein levels are *induced* by [TNF-alpha] in JAR cells . Positive_regulation TNF NFIB 8939900 398541 Here , we report that binding sites for the transcription factor *mediate* antagonistic TGF-beta and [TNF-alpha] transcriptional regulation in NIH3T3 fibroblasts . Positive_regulation TNF NFKB1 10076530 560577 CVT-634 ( 5-methoxy-1-indanone-3-acetyl-leu-D-leu-1-indanylamide ) prevented lipopolysaccharide (LPS) , [tumor necrosis factor (TNF)-] , and phorbol ester induced *activation* of in vitro by preventing signal induced degradation of I kappa B-alpha . Positive_regulation TNF NFKB1 10079106 595584 These findings support a pathway by which LPS stimulation of neutrophils results in activation of MKK3 , which in turn activates p38alpha MAPk , ultimately regulating adhesion , activation , *enhanced* gene expression of [TNF-alpha] , and regulation of TNF-alpha synthesis . Positive_regulation TNF NFKB1 10086338 599644 In particular , we demonstrate that the [TNF-alpha] effect is *mediated* by ( p50/p65 ) and RelA/RelA ( p65/p65 ) NF-kappaB complexes binding the TNF-alpha response element (TaRE) located in the region [ -252/-230 ] , with RelA acting as the transcriptional activator . Positive_regulation TNF NFKB1 10201927 605678 Our observations support the notion that full LPS response of [TNF] gene *requires* both and non-NF-kappaB nuclear proteins . Positive_regulation TNF NFKB1 10232679 611398 Treatment with N ( G ) -nitro-L-arginine methyl ester ( L-NAME ) did not affect initial *activation* of by [IL-1beta/TNF-alpha] , but unveiled an inhibitory effect of NO generation on NF-kappaB activity after 4 h . Positive_regulation TNF NFKB1 10342828 616509 Treatment of the cells with 17beta-E2 partially suppressed the *activation* of by [TNF alpha] , but did not block cytokine induced IL-6 secretion . Positive_regulation TNF NFKB1 10357911 618579 Transcriptional activation of the [TNF-alpha] gene in LPS stimulated macrophages is *dependent* upon activity . Positive_regulation TNF NFKB1 10385418 625462 [TNF] *induced* activation in both primary islet cells and NIT-1 cells . Positive_regulation TNF NFKB1 10416616 631440 The increased cytokine expression was associated with an increase in constitutive and [TNF-alpha-inducible] *activation* of as demonstrated by electrophoretic mobility shift assay and luciferase-reporter gene assay . Positive_regulation TNF NFKB1 10440583 635386 The role of superoxide radical in [TNF-alpha] *induced* activation . Positive_regulation TNF NFKB1 10449410 637273 The molecular basis for this resistance relies on an almost complete abrogation of *dependent* accumulation of [TNF-alpha] in the serum and a down-regulation of inducible nitric oxide synthase (iNOS) , leading to decreased NO synthesis , which is the main source of free radical generation during inflammation . Positive_regulation TNF NFKB1 10449775 637404 *Activation* of either or c-Jun NH ( 2 ) -terminal kinase/stress activated protein kinase by [tumor necrosis factor] , CD27 , and CD40 was not abrogated in traf5 ( -/- ) mice . Positive_regulation TNF NFKB1 10477576 643046 [TNF-alpha] rapidly *induced* marked activation of nuclear transcription factor in all 4 cell lines . Positive_regulation TNF NFKB1 10485710 644414 Here we show that the Akt serine-threonine kinase is involved in the *activation* of by [tumour necrosis factor (TNF)] . Positive_regulation TNF NFKB1 10485710 644529 Thus , both Akt and NIK are necessary for [TNF] *activation* of . Positive_regulation TNF NFKB1 10485710 644537 Mutation of this amino acid blocks phosphorylation by Akt or [TNF] and *activation* of . Positive_regulation TNF NFKB1 10486238 644707 *Role* of transcription factor in asbestos induced [TNFalpha] response from macrophages . Positive_regulation TNF NFKB1 10497896 647554 Induction of [TNFalpha] in macrophages by vanadate is *dependent* on activation of transcription factor and free radical reactions . Positive_regulation TNF NFKB1 10497896 647558 This is supported by evidence that inhibition of activation by SN50 , a specific NF-kappaB inhibitor , *resulted* in a decrease in the [TNFalpha] production . Positive_regulation TNF NFKB1 10498648 647628 The aim of this study is to investigate how PAF participates in the LPS induced and *mediated* regulation of [TNF-alpha] and CINC in regenerating rat livers . Positive_regulation TNF NFKB1 10517537 652144 To know the regulation of the expression of gamma-GCS gene , in the present study , we show evidences that gamma-GCS heavy subunit is upregulated by oxidative stress by ionizing radiation and [TNF-alpha] *mediated* by , and impairment of the expression of gamma-GCS by TNF-alpha in diabetic condition . Positive_regulation TNF NFKB1 10541434 563489 Fibrosis is frequently associated with inflammation , which is accompanied by increased levels of [tumor necrosis factor-alpha (TNFalpha)] and *activation* of the transcription factor . Positive_regulation TNF NFKB1 10544256 564105 *Activation* of by [TNF-alpha] was reproduced in primary hOBs . Positive_regulation TNF NFKB1 10593965 572937 These findings suggest a novel role for 5-ASA in the management of IBD by disrupting [TNFalpha] *activation* of . Positive_regulation TNF NFKB1 10615065 656330 however , [TNF-alpha] *induced* both AP-1 and binding activities in BET-1A cells . Positive_regulation TNF NFKB1 10616907 575885 We report that [TNF] induces DNA replication in growth arrested LE6 cells and that its effect *involves* the activation of and STAT3 and an increase in c-myc and IL-6 mRNAs . Positive_regulation TNF NFKB1 10617597 657066 Incubation of macrophages with PAO1 led to *dependent* expression of inducible nitric-oxide synthase , COX-2 , and [tumor necrosis factor-alpha] , which was unaffected by inhibition of Rac1 or Cdc42 function . Positive_regulation TNF NFKB1 10619820 657339 Inhibition of by pyrrolidine dithiocarbamate *attenuated* IL-1beta and [TNF-alpha] synthesis . Positive_regulation TNF NFKB1 10640750 660643 The *activation* of transcription factor by [TNF] involves the stimulation of a novel signaling cascade . Positive_regulation TNF NFKB1 10640779 660716 Our data show that [TNF-alpha] production by LPS stimulated AMs from asymptomatic HIV-seropositive and -seronegative individuals is *regulated* via the phospholipase C pathway and by DNA binding activity without obvious changes in I kappa B-alpha or I kappa B-beta protein concentrations . Positive_regulation TNF NFKB1 10653605 663287 In addition , inhibition of activation by gliotoxin and pyrrodiline dithiocarbamate , *inhibited* LPS induction of [TNFalpha] and MnSOD mRNAs . Positive_regulation TNF NFKB1 10700573 672413 Sodium valproate inhibits production of [TNF-alpha] and IL-6 and *activation* of . Positive_regulation TNF NFKB1 10707928 673451 In PANC-1 cells , IL-1beta and [TNF-alpha] *induced* a rapid activation of , and TGF-beta1 enhanced this activation slightly . Positive_regulation TNF NFKB1 10799874 691383 These effects were specific to HIV-tat , as *activation* of by PMA , LPS , H2O2 , and [TNF] was minimally affected . Positive_regulation TNF NFKB1 10801347 691515 Furthermore , we demonstrate that activation of [TNF-alpha] by gp350 is *mediated* by through signal transduction pathways involving PKC , PI3-K and tyrosine kinases . Positive_regulation TNF NFKB1 10809757 692606 The activity of [TNFalpha] was *blocked* by inhibitors . Positive_regulation TNF NFKB1 10815618 580208 Inhibition of *inhibits* the LPS- but not the MTP-PE induced release of [TNF-alpha] , nitric oxide and PGE2 . Positive_regulation TNF NFKB1 10821844 694651 We have previously shown that alpha-melanocyte stimulating hormone ( alpha-MSH ) can oppose [tumor necrosis factor] alpha *activation* of ( 1-2 h ) and intercellular adhesion molecule 1 up-regulation ( mRNA by 3 h and protein by 24 h ) in melanocytes and melanoma cells . Positive_regulation TNF NFKB1 10837498 699421 The following observations supported that both and AP-1 *mediated* enhanced [TNFalpha] transcription by CHG : 1 ) A 295-base pair fragment of the proximal TNFalpha promoter containing NF-kappaB and AP-1 sites reproduced the effects of CHG on TNFalpha transcription in a luciferase reporter assay , 2 ) mutational analyses of both NF-kappaB and the AP-1 sites abrogated 90 % of the luciferase activity , 3 ) gel-shift analysis using the binding sites showed activation of NF-kappaB and AP-1 in CHG nuclear extracts , and 4 ) Western blot analyses demonstrated elevated nuclear levels of p65 and p50 and decreased cytosolic levels of IkappaBalpha in CHG treated monocytes . Positive_regulation TNF NFKB1 10839991 699640 *Activation* of endogenous by [tumour necrosis factor-alpha (TNF-alpha)] was also able to inhibit the Smad7 promoter in human embryonic kidney 293 cells . Positive_regulation TNF NFKB1 10843668 700094 The effect is mediated via the p80 type II [TNF] receptor ( TNFR2 ) , which *induces* among other factors , leading to an enhanced secretion of the chemokines macrophage-inflammatory protein-1alpha , macrophage-inflammatory protein-1beta , and RANTES . Positive_regulation TNF NFKB1 10845915 700721 In contrast , AG-490 did not affect [tumor necrosis factor] alpha *activation* of at similar concentrations of drug . Positive_regulation TNF NFKB1 10878378 708965 Rotenone , an inhibitor of mitochondrial complex I , abolished the increase in ROS signal , the *activation* of , and [TNF-alpha] gene transcription during hypoxia . Positive_regulation TNF NFKB1 10878378 708967 These results indicate that mitochondrial ROS are required for the hypoxic activation of NF-kappa B and [TNF-alpha] gene transcription , but not for the LPS *activation* of . Positive_regulation TNF NFKB1 10881930 709227 IL-1beta and [TNF-alpha] *induced* a rapid activation of in PANC-1 cells , and the increase in chemokine mRNA expression correlated with NF-kappaB activation . Positive_regulation TNF NFKB1 10882136 709447 A dominant negative mutant of IKKepsilon blocks induction of NF-kappaB by both PMA and activation of the T cell receptor but has no effect on the *activation* of by [TNFalpha] or IL-1 . Positive_regulation TNF NFKB1 10884313 709535 However , pretreatment with oATP downregulated *activation* of and AP-1 by IL-1beta or [TNFalpha] . Positive_regulation TNF NFKB1 10921504 717357 antioxidants significantly inhibited both the in vivo and in vitro PAF induced NF-kappaB activation and *dependent* [TNF-alpha] expression . Positive_regulation TNF NFKB1 10930442 719829 Here we demonstrate that the *activation* of by [TNF-alpha] interferes with thyroid-hormone action as demonstrated by impairment of T ( 3 ) -dependent induction of 5'-DI gene expression in HepG2 cells . Positive_regulation TNF NFKB1 10930989 720126 We assessed the effect of APC on LPS induced [tumour necrosis factor alpha (TNF-alpha)] production and on the *activation* of the central proinflammatory transcription factor in a THP-1 cell line . Positive_regulation TNF NFKB1 10938077 737429 [TNFalpha] , as well as certain other stimuli , also *induces* the phosphorylation of the proteins . Positive_regulation TNF NFKB1 10982776 732007 We examined whether [TNF-alpha] induction of PAP I expression was *mediated* by or MAP kinases by using specific inhibitors of both pathways . Positive_regulation TNF NFKB1 10984605 732218 The present study investigates the role of Akt in the *activation* of by [tumor necrosis factor-alpha] ( TNF alpha , 10 ng/ml ) and PDGF-BB ( 20 ng/ml ) in human vascular smooth muscle cells (SMC) , skin and foreskin fibroblasts . Positive_regulation TNF NFKB1 11007940 735637 [TNF-alpha] also *induces* the activation of and AP-1 and the subsequent increase in gamma-GCS heavy subunit transcription in these cells . Positive_regulation TNF NFKB1 11018074 737676 In wild-type mice , ethanol caused severe liver injury via a mechanism involving gut derived endotoxin , CD14 receptor , production of electron spin resonance-detectable free radicals , *activation* of the transcription factor , and release of cytotoxic [TNF-alpha] from activated Kupffer cells . Positive_regulation TNF NFKB1 11044363 742467 These TNF-alpha resistant HNSCC lines expressed TNF receptor I , and exhibited constitutive and [TNF-alpha-inducible] *activation* of as demonstrated by nuclear localization of NF-kappaB p65 by immunohistochemistry . Positive_regulation TNF NFKB1 11044363 742469 We conclude that HNSCC that exhibit constitutive and [TNF-alpha-inducible] *activation* of transcription factor are resistant to TNF-alpha , and that inhibition of NF-kappaB sensitizes HNSCC to TNF-alpha caspase mediated cytotoxicity . Positive_regulation TNF NFKB1 11045427 742600 In order to provide further understanding of determinants of TNF-alpha responses , we studied [TNF-alpha] *induced* activation and variable tumour responses . Positive_regulation TNF NFKB1 11045427 742602 We analysed the kinetics of [TNF-alpha] *induced* activation in colorectal cancer cells and determined whether it is possible to sensitize colorectal tumour cells to TNF-alpha by modulation of NF-kappaB signalling . Positive_regulation TNF NFKB1 11058855 746238 Elastase , carboxypeptidase A , and lipase induced degradation of I kappa B-beta ( but not I kappa B-alpha ) , *activation* of , and production of [TNF-alpha] protein , whereas inhibition of I kappa B with pyrrolidine dithiocarbamate attenuated this response . Positive_regulation TNF NFKB1 11087727 786356 [Tumor necrosis factor-alpha] *induces* distinctive signaling within human dermal fibroblasts . Positive_regulation TNF NFKB1 11095928 755639 Thus does not *enhance* basal or [TNF-alpha-responsive] PGHS-2 transcription in amnion derived AV-3 cells . Positive_regulation TNF NFKB1 11104733 756514 However , increased [ cAMP ] ( i ) in HASM neither activated NF-kappaB nor altered [TNF-alpha-] *induced* DNA binding activity . Positive_regulation TNF NFKB1 11112416 757587 *Activation* of by [TNF-alpha] mediates many functions of TNF-alpha . Positive_regulation TNF NFKB1 11179036 784431 Inhibition of myocyte activation by overexpression of myocyte I-kappaBalpha is *sufficient* to block cardiac [TNF-alpha] production and prevent cardiac dysfunction after LPS challenge . Positive_regulation TNF NFKB1 11225736 580995 We found that *activation* of by [TNF-alpha] was blocked by rotenone or amytal , inhibitors of complex I of the mitochondrial respiratory chain . Positive_regulation TNF NFKB1 11237861 790422 In the present study we investigated how TSH is involved in the *activation* of by [TNF-alpha] in the cells . Positive_regulation TNF NFKB1 11259437 818722 Activation of the [TNF-alpha] gene promoter was *dependent* on activation of . Positive_regulation TNF NFKB1 11259437 818724 Inhibition of activation *led* to a dramatic reduction in both [TNF-alpha] promoter activity and TNF-alpha protein production in the response to zymosan A. Mutation of a major NF-kappaB binding site ( kappa3 ) in the gene promoter resulted in a significant decrease in the induction of the gene promoter by zymosan A , while mutation of Egr or CRE sites failed to inhibit the response to zymosan . Positive_regulation TNF NFKB1 11264769 796658 An inhibition of by pyrrolidine dithiocarbamate *attenuated* IL-1beta and [TNF-alpha] synthesis . Positive_regulation TNF NFKB1 11279049 819484 These data show that [TNF-alpha] decreases AQP5 mRNA and protein expression and that the molecular pathway for this effect *involves* TNFR1 and activated . Positive_regulation TNF NFKB1 11312646 805299 tightly *regulates* [TNF-alpha] transcription . Positive_regulation TNF NFKB1 11336164 809289 [TNF] and IL-1 *induced* activation . Positive_regulation TNF NFKB1 11337375 812178 [TNF-alpha] *induced* maximal translocation of into the nucleus of non-CF as well as CF airway cells within 20 minutes . Positive_regulation TNF NFKB1 11356844 834471 Expression of PTEN in PC-3 cells to a level comparable with that endogenously present in DU145 cells inhibited [TNF] *activation* of . Positive_regulation TNF NFKB1 11382928 820941 [TNFalpha] *induces* in association with the growth and morphogenesis of normal and transformed rat mammary epithelial cells . Positive_regulation TNF NFKB1 11382928 820946 There were no changes in the levels of p65 or c-rel . [TNFalpha] *induced* a pronounced and sustained increase of a p50 homodimeric complex in both normal and transformed MEC . Positive_regulation TNF NFKB1 11385283 821641 Inhibitors of activation such as N-acetylcysteine or N-tosyl-L-phenylalanine chloromethyl ketone can *suppress* Fc epsilon RI-induced [TNF-alpha] and MCP-1 release . Positive_regulation TNF NFKB1 11391531 822943 In conclusion our results show that activation of the rat Mdr1b gene by [TNF-alpha] is a *result* of signaling and independent of p53 . Positive_regulation TNF NFKB1 11402028 842917 IKKalpha and IKKbeta were both required downstream modulators of LPS activated Rac1 , since the expression of either of the IKK dominant mutants ( IKKalphaKM or IKKbetaKA ) drastically reduced *dependent* [TNFalpha] secretion . Positive_regulation TNF NFKB1 11450703 836649 Thus , it is shown that the *activation* of p65/p50 by [TNF-alpha] plays a cardinal role in inducing the expression of MMP-1 , MMP-3 , ICAM-1 , and COX-2 genes , which are involved in matrix degradation and inflammatory reaction in chondrocytes , leading to chondrocytic chondrolysis . Positive_regulation TNF NFKB1 11461927 850944 Modulation of [tumor necrosis factor] apoptosis *inducing* ligand- induced activation by inhibition of apical caspases . Positive_regulation TNF NFKB1 11500081 846802 Cells insensitive to TNF-alpha may respond to [TNF-alpha] through TNFR that *induces* transcription of and FLIP . Positive_regulation TNF NFKB1 11500296 846996 RA did not alter LPS stimulated and activation protein-1 binding but significantly decreased TNF-alpha mRNA stability in HM. HM isolated from the ALD model showed significant decreases in all-trans RA ( -48 % ) and 9-cis RA ( -61 % ) contents , RA response element ( RARE ) binding , and mRNA levels for RARbeta , RXRalpha , and cytosolic retinol binding protein-1 , whereas [TNF-alpha] mRNA expression was *induced* . Positive_regulation TNF NFKB1 11505407 847914 TNFalpha induced inhibition of the EpCAM expression is mediated by [TNF] receptor 1 through the TNF receptor associated death domain protein ( TRADD ) and by the *activation* of , and it can be blocked by dominant negative variants of TRADD and the NF-kappaB inhibitor , IkappaB . Positive_regulation TNF NFKB1 11509005 848226 [TNF-alpha] also *induced* translocation to the nucleus , an essential step in GM-CSF mRNA production . Positive_regulation TNF NFKB1 11549416 856831 These findings suggested that activation of HIV-1 LTR by mycobacteria was mainly mediated by *induced* secondary release of cytokine [TNF-alpha] . Positive_regulation TNF NFKB1 11557763 875283 As both [TNF] and PMA rapidly *induce* activation this suggests that NEMO/IKKgamma dependent activation of the NF-kappaB pathway is necessary but not sufficient for up-regulation of TRAIL in T cells . Positive_regulation TNF NFKB1 11561906 862728 TGF-beta as well as [TNF-alpha] *induced* activation of and upregulated bcl-xL . Positive_regulation TNF NFKB1 11698503 878180 In naive cells , LPS , [TNF-alpha] , and IL-1beta *induced* IkappaBalpha degradation , kinase phosphorylation , and DNA binding . Positive_regulation TNF NFKB1 11753638 890159 [TNF] *induced* activation but not AP-1 activation in LNCaP cells . Positive_regulation TNF NFKB1 11755130 890229 In circulating blood neutrophils , [TNF-alpha] *induced* activation of , whereas , in tissue neutrophils , NF-kappa B had been already activated without any stimulation , and no further activation was induced by the treatment with TNF-alpha . Positive_regulation TNF NFKB1 11775855 581315 LPS might activate in the PIMs , and *induce* the increase of transcription and expression of [TNF-alpha] gene ; Positive_regulation TNF NFKB1 11777983 899874 EMSAs demonstrated that IL-17 , IL-1beta , and [TNF-alpha] *induced* activation within 1.5 h after stimulation , and a blockade of NF-kappaB activation by the pyrrolidine derivative of dithiocarbamate and tosyl-phe-chloromethylketone markedly reduced the IL-17- , IL-1beta- , or TNF-alpha induced IL-6 gene expression . Positive_regulation TNF NFKB1 11841920 912261 HM from an animal model of ALD have increased nonheme iron content accompanied by increased generation of EPR detected radicals , activation , and [TNFalpha] *induction* , all of which are normalized by ex vivo treatment of the cells with deferiprone . Positive_regulation TNF NFKB1 11851362 913230 Electrophoretic mobility shift assay demonstrated that [TNF-alpha] *induced* DNA binding . Positive_regulation TNF NFKB1 11867340 917997 In contrast , [TNF-alpha] release by IgA treated HAM is not dependent on oxidants and only partly *dependent* on . Positive_regulation TNF NFKB1 11896607 920951 In such a scenario , strong apoptotic agent [TNFalpha] , further *induces* activation rather than inducing apoptosis . Positive_regulation TNF NFKB1 11918294 925607 The nuclear transcription factor *mediates* [TNF] signaling and this transcription complex is necessary for osteoclastogenesis . Positive_regulation TNF NFKB1 11918684 894993 APC directly *inhibits* the production of [TNF-alpha] by inhibiting the activation of both and activator protein-1 in monocytes stimulated with LPS . Positive_regulation TNF NFKB1 11922866 984258 Respiratory syncytial virus and [TNF alpha] induction of chemokine gene expression *involves* differential activation of Rel A and . Positive_regulation TNF NFKB1 11922866 984267 DNA binding studies using NF-kappaB subunit specific binding ELISA demonstrated that RSV and [TNFalpha] *induced* different binding complexes containing Rel A ( p65 ) and NF-kappaB1 ( p50 ) . Positive_regulation TNF NFKB1 11934806 927865 Concomitantly , ExPLIs inhibited the LPS induced activation of by LPS but not its *activation* by [TNF-alpha] or IL-1 . Positive_regulation TNF NFKB1 11943805 928748 Moreover , little translocation is *induced* by [TNF-alpha] in neurons of TNFRI -/- , whereas NF-kappaB subunit p65 is still translocated from the cytoplasm into the nucleus in neurons from wild-type and TNFRII -/- mice . Positive_regulation TNF NFKB1 11950023 930281 [TNF] *induced* nuclear translocation and DNA binding in all OA synovial tissue explants , although there were no consistent effects on AP-1 DNA binding . Positive_regulation TNF NFKB1 11994432 938945 Evidence for a dual mechanism for IL-10 suppression of [TNF-alpha] production that does not *involve* inhibition of p38 mitogen activated protein kinase or in primary human macrophages . Positive_regulation TNF NFKB1 12010810 941310 In this study , [TNF-alpha] alone *induced* nuclear translocation , cIAP-1 and cIAP-2 up-regulation , and MM cell proliferation ; Positive_regulation TNF NFKB1 12022761 943299 Curcuminoids , derived from the plant Curcuma domestica Val. , have been shown to be free radical scavengers that suppress the production of superoxide by macrophages and potent anti-inflammatory agents that inhibit the lipopolysacharide (LPS) induced production of [tumor necrosis factor alpha (TNFalpha)] , interleukin (IL)-1beta , and the *activation* of in human monocytic derived cells . Positive_regulation TNF NFKB1 12023002 943485 Elastase induced overexpression of [TNF] messengerRNA and *activation* of was attenuated by Gd. Pancreatic elastase induces a pattern of liver injury similar to that seen during acute pancreatitis by activating cytokine production and gene expression within Kupffer cells via NF-kappa B . Positive_regulation TNF NFKB1 12091251 960077 RAW 264.7 macrophages exhibited enhanced TNF-alpha production and NF-kappaB activation in response to silica , whereas IC-21 macrophages did not produce [TNF-alpha] in response to silica and did not *induce* nuclear binding . Positive_regulation TNF NFKB1 12091251 960081 In addition , [TNF-alpha] and NF-kappaB activation , but not apoptosis , were induced by lipopolysaccharide (LPS) in both cell lines , and inhibition *reduced* LPS induced TNF-alpha release . Positive_regulation TNF NFKB1 12091251 960083 These data suggest that [TNF-alpha] induction is *dependent* on activation in both cell lines . Positive_regulation TNF NFKB1 12133965 967042 Mitogen activated protein kinases and are *involved* in [TNF-alpha] responses to group B streptococci . Positive_regulation TNF NFKB1 12133965 967050 Here we investigate the *role* of mitogen activated protein kinases ( MAPKs ) and in [TNF-alpha] production by human monocytes stimulated with GBS or LPS , used as a positive control . Positive_regulation TNF NFKB1 12133965 967057 Selective inhibitors of ERK 1/2 ( PD98059 or U0126 ) , p38 ( SB203580 ) , or ( caffeic acid phenetyl ester ( CAPE ) ) could all significantly *reduce* [TNF-alpha] production , although none of the inhibitors used alone was able to completely prevent TNF-alpha release . Positive_regulation TNF NFKB1 12135878 967618 [TNFalpha] *induced* IkappaB phosphorylation and activation . Positive_regulation TNF NFKB1 12162440 971987 Oxidative stress and [TNF-alpha] *induce* histone acetylation and activation in alveolar epithelial cells : potential mechanism in gene transcription in lung inflammation . Positive_regulation TNF NFKB1 12168567 973641 [Tumour necrosis factor-alpha (TNF-alpha)] or endotoxin *induce* the activation of two major transcription factors , ( nuclear factor-kappaB ) and AP-1 ( activating protein-1 ) , which in turn induce genes involved in chronic and acute inflammatory responses . Positive_regulation TNF NFKB1 12169272 973729 Even though LTbetaR was shown to recruit [TNF-receptor associated factor (TRAF)] 2 , 3 , and 5 , and to *induce* cell apoptosis or activation , however , the downstream signaling leading to chemokine expression is not illustrated yet . Positive_regulation TNF NFKB1 12176740 975492 Inhibition of by a specific NF-kappaB inhibitor , caffeic acid phenylethyl ester , or by dominant expression of the NF-kappaB inhibitory subunit IkappaB *caused* an increase in FasL induced apoptosis and a reduction in [TNF-alpha] expression . Positive_regulation TNF NFKB1 12181188 977495 In conclusion , Fe2+ serves as a direct agonist to activate IKK , , and TNF-alpha promoter activity and to *induce* the release of [TNF-alpha] protein by cultured Kupffer cells in a redox status dependent manner . Positive_regulation TNF NFKB1 12192035 980664 Mechanism of rapid transcriptional *induction* of [tumor necrosis factor] alpha-responsive genes by . Positive_regulation TNF NFKB1 12195699 981749 These observations strongly suggest that APC *inhibited* LPS induced [TNF-alpha] production by inhibiting the activation of both and AP-1 and that the inhibitory activity of APC might depend on its serine protease activity . Positive_regulation TNF NFKB1 12203103 983118 The *role* of in enhancement of [TNF-alpha] production was confirmed in experiments in which MG132 , an inhibitor of NF-kappaB activation , reversed the effect of AdAMP . Positive_regulation TNF NFKB1 12219013 986602 The 2 groups of mice were analyzed for serum levels of interferon-gamma , [tumor necrosis factor-alpha] , and interleukin-1beta as well as *activation* of and STAT1 , 2 proinflammatory transcription factors . Positive_regulation TNF NFKB1 12235132 1012315 The early activity *led* to the induction of proinflammatory cytokines , [tumor necrosis factor (TNF)] , and interleukin (IL)-1beta , which are known to be efficient inducers of NF-kappaB . Positive_regulation TNF NFKB1 12354747 993633 Both LPS and [TNF-alpha] *induced* significant activation , cyclooxygenase-2 (COX-2) expression , and inducible NO synthase (iNOS) and cytokine production ; Positive_regulation TNF NFKB1 12361763 995017 [TNF] alone can *induce* MCMV IE-1 gene expression and activation of and AP-1 in some tissues . Positive_regulation TNF NFKB1 12361763 995022 We propose that induction of IE-1 gene expression is the first step in reactivation of the virus in an immunocompromised transplant recipient , and that it occurs as a result of the allogeneic response , which induces expression of [TNF] and subsequent *activation* of , and ischemia/reperfusion injury , which induces activation of AP-1 . Positive_regulation TNF NFKB1 12404274 1009772 The results showed that [TNF-alpha] can *induce* activation of and that the activation and translocation of NF-kappaB into the nucleus is responsible for promoting the 3-D cytomorphologic differentiation of anaplastic thyroid carcinoma cells , which was inhibited by the NF-kappaB translocation inhibitor , NF-kappaB SN50 . Positive_regulation TNF NFKB1 12452437 1020564 Construction and testing of a series of promoter mutants demonstrated that is *essential* for both [TNFalpha] and IE1 stimulation . Positive_regulation TNF NFKB1 12452437 1020566 Specific inhibition of signalling by co-expression of a dominant negative IkappaB variant *reduced* [TNFalpha] stimulation of the IE1/2 enhancer/promoter by up to 80 % . Positive_regulation TNF NFKB1 12475794 1023718 [TNF-alpha] treatment and depolarization *activation* of differed significantly in that TNF-alpha activation was not blocked by PD98059 . Positive_regulation TNF NFKB1 12480916 1024250 Of interest , [TNF-alpha] *induced* persistent binding activity even in the presence of SNP , mirroring apoptosis protection effects . Positive_regulation TNF NFKB1 12490536 1037797 Inhibition of AR attenuated [TNF-alpha] and hyperglycemia induced *activation* of protein kinase C ( PKC ) , phosphorylation of the inhibitory subunit of nuclear factor-kappaB (NF-kappaB) , and stimulation of , but it did not prevent the activation of NF-kappaB and PKC by phorbol ester . Positive_regulation TNF NFKB1 12509805 1038768 Finally , IL-1beta and [TNF-alpha] *induced* degradation of 's bound inhibitory protein , IkappaB-alpha , leading to translocation of NF-kappaB into the nucleus . Positive_regulation TNF NFKB1 12556975 1051794 *Activation* of by [TNF-alpha] prior to TRAIL exposure increased resistance of the cells to TRAIL mediated apoptosis . Positive_regulation TNF NFKB1 12631113 1067659 The present data indicate that [TNF-alpha] *activation* of PKCzeta/iota , p42/44 MAPK , c-Jun/AP-1 , and are involved in TNF-alpha stimulated MC fractalkine expression , with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro . Positive_regulation TNF NFKB1 12635574 1068507 Our results indicated that [TNF-alpha] production was *induced* by D. farinae in PBMCs of patients with atopic asthma by the activation of via CD23 . Positive_regulation TNF NFKB1 12637573 1091953 We have shown previously that [tumor necrosis factor alpha-(TNF)] strongly *induces* osteoclastogenesis of preosteoclasts and do so through activation of the transcription factor , . Positive_regulation TNF NFKB1 12649382 1070548 These observations strongly suggest that gabexate mesilate *inhibited* LPS induced [TNF-alpha] production in human monocytes by inhibiting activation of both and AP-1 . Positive_regulation TNF NFKB1 12699902 1081660 We demonstrate in both cell types that TNF-alpha activates NF-kappaB , and HQ exposure inhibits *activation* of by [TNF-alpha] in a dose dependent manner . Positive_regulation TNF NFKB1 12729461 1106725 Taken together , our results demonstrate that [TNF-alpha] induces the expression of fractalkine and CX3CR1 in rat aortic SMCs and that this induction is *mediated* by activation . Positive_regulation TNF NFKB1 12746218 1088661 The effects of sauchinone on the inducible nitric oxide synthase (iNOS) , [tumor necrosis factor-alpha (TNF-alpha)] and cyclooxygenase 2 (COX-2) gene expression and on the *activation* of transcription factors , , CCAAT/enhancer binding protein (C/EBP) , activator protein-1 (AP-1) and cAMP-response element binding protein ( CREB ) were determined in Raw264.7 cells as part of the studies on its anti-inflammatory effects . Positive_regulation TNF NFKB1 12867288 1112062 The maximum activation of was *induced* by [TNF-alpha] or MoCM at a Se concentration ( 0.5 approximately 1 micromol/l ) which was half the level of the serum Se in healthy subjects and was equivalent to level in subjects with pathological conditions together with high serum CRP values . Positive_regulation TNF NFKB1 12874341 1115072 Activation of and AP-1 by P. aeruginosa GLP may be *involved* not only in [TNF-alpha] induction but also in many of the inflammatory responses triggered in the course of infection with P. aeruginosa . Positive_regulation TNF NFKB1 12885587 1116713 It is concluded that T ( 3 ) -induced oxidative stress enhances the DNA binding activity of NF-kappaB and the *dependent* expression of [TNF-alpha] and IL-10 genes . Positive_regulation TNF NFKB1 12917420 1157667 Remarkably , we found that *activation* of by [TNF-alpha] selectively inhibited TCDD induced serine 2 phosphorylation in mouse liver cells , suggesting that residue-specific phosphorylation of RNA PII CTD at the cyp1a1 promoter is an important regulatory point upon which signal `` cross-talk '' converges . Positive_regulation TNF NFKB1 12932353 1132534 We now report that in vitro exposure of neutrophils to C5a causes increased levels of IkappaBalpha , decreased *dependent* gene transcription of [TNFalpha] , and decreased lipopolysaccharide (LPS) induced TNFalpha production . Positive_regulation TNF NFKB1 12934647 1132830 IL-1beta and [TNF-alpha] can *induce* extracellular signal regulated kinase ( ERK ) , IKK , IkappaB degradation and activation . Positive_regulation TNF NFKB1 1315830 185514 mAb H398 is shown to efficiently block not only [TNF-] but also lymphotoxin mediated *activation* of . Positive_regulation TNF NFKB1 1315830 185516 Together , the results of this study indicate that TR55 is both necessary and sufficient for mediating [TNF] *activation* of . Positive_regulation TNF NFKB1 14521729 1148004 1.5 , 3.0 , 6.0 , and 12.0 hours after the onset of experiment the amount of ascitic fluid was measured , blood was extracted from abdominal aorta , changes of pancreas was observed , pancreatic tissues were stained with HE , and flow cytometry ( FCM ) and enzyme linked immuno-sorbent assay ( ELISA ) were used to examine the content of [TNF-alpha] protein and *activation* of ( number of positive cells/50 micro l ) in the pancreatic tissues . Positive_regulation TNF NFKB1 14527367 1148355 mRNA expression of proinflammatory cytokines ( IL-1 beta , IL-6 , [TNF-alpha] , and MCP-1 ) and *activation* of of HMC were measured using Reverse transcription-polymerase chain reaction ( RT-PCR ) and electrophoretic mobility shift assay ( EMSA ) respectively . Positive_regulation TNF NFKB1 14566965 1155096 In both prechondrocytes and articular chondrocytes , [TNFalpha] *induced* concentration dependent activation of MEK1/2 and , but not p38 or JNK . Positive_regulation TNF NFKB1 14646384 1173135 Azelastine *inhibited* hCBMC secretion of IL-6 , [TNF-alpha] and IL-8 , possibly by inhibiting intracellular Ca2+ ions and activation . Positive_regulation TNF NFKB1 14662866 1177641 [TNF-alpha] *activation* of , in contrast , did not increase NGAL synthesis , even though induced binding of NF-kappaB to the NGAL promoter was observed in vitro . Positive_regulation TNF NFKB1 14715080 1225544 We observed that *activation* of by [TNFalpha] ( tumour necrosis factor alpha ) inhibited both basal and androgen stimulated PSA expression , and that this down-regulation occurred at the promoter level , as confirmed by the super-repressor IkappaBalpha ( S32A/S36A ) , a dominant negative inhibitor of NF-kappaB . Positive_regulation TNF NFKB1 14736953 1199594 We investigated the *role* of and AP-1 in [tumour necrosis factor alpha (TNF-alpha)] induced monocyte chemoattractant protein 1 ( MCP-1 ) production in cultured human glomerular endothelial cells ( HGEC ) . Positive_regulation TNF NFKB1 14963056 1208750 The effect of eicosapentaenoic acid ( EPA ) , a major n-3 fatty acid in fish oil , on the lipopolysaccharide (LPS) induced expression of [TNF-alpha] and *activation* of were investigated . Positive_regulation TNF NFKB1 14980010 1213836 The increased production of NO and [TNF-alpha] from rIFN-gamma plus C. majus stimulated cells was almost completely *inhibited* by inhibitor , pyrrolidine dithiocarbamate ( 100 microM ) . Positive_regulation TNF NFKB1 14982564 1214339 Endotoxin caused transient production of [TNF-alpha] and IL-6 and *activation* of in the intestine at peak times of 1 , 4 and 1 h , respectively . Positive_regulation TNF NFKB1 14984720 1214710 We examined the effects of SUN C8079 on the transcriptional responses of NF-kappaB , on *activation* of in electrophoretic mobility shift assay , and on the gene expressions of [tumor necrosis factor (TNF)-alpha] and iNOS . Positive_regulation TNF NFKB1 15041472 1224414 These findings suggest that the inhibition of the LPS induced production of NO and [TNF-alpha] by the 2'-hydroxychalcone derivatives is *due* to the inhibition of and AP-1 activations . Positive_regulation TNF NFKB1 15068390 1184281 Kinetic experiments in HeLa cells show that [TNF] stimulation first *induced* DNA binding within 30 minutes , followed by I kappa B-alpha gene transcription 30 minutes later . Positive_regulation TNF NFKB1 15106733 1240536 [TNF-alpha] plus IFN-gamma can *induce* extracellular signal regulated kinase ( ERK ) , IKK , IkappaB degradation and activation . Positive_regulation TNF NFKB1 15144120 1247551 [TNF-alpha] expression can be *mediated* by transcription factor . Positive_regulation TNF NFKB1 15144120 1247553 In vitro expression of [TNF-alpha] and *activation* of in synovial fibroblasts after infection with Yersinia enterocolitica or Salmonella enteritidis was analysed by electrophoretic mobility shift assay , Western blot assay and real-time PCR . Positive_regulation TNF NFKB1 15177881 1255053 [TNF-alpha] stimulation , which *induces* activation , evoked up to 10-fold reduction of TFF3 expression in the colon tumour cell line HT-29 . Positive_regulation TNF NFKB1 15248852 1271246 The inhibitors , calpain inhibitor 1 ( 10 microm ) , pentoxifylline ( 0.5 mm ) , pyrrolidine dithiocarbamate ( PDTC , 10 microm ) or gliotoxin ( 1 pg/mL ) *reduced* the generation of GM-CSF , [TNF-alpha] and IL-8 in parallel with their inhibition of NF-kappaB . Positive_regulation TNF NFKB1 15265367 1275308 The *results* of EMSA showed that activation by [TNF-alpha] in HL-60 cells was induced in a dose dependent manner , but was almost completely inhibited by mutant IkappaBalpha repressor in transfected cells . Positive_regulation TNF NFKB1 15293554 1278960 The mRNA accumulation of IL-8 , MCP-1 , RANTES , and eotaxin , and activation of were *induced* by [TNF-alpha] for 2 h ; Positive_regulation TNF NFKB1 15320513 1286521 APC *inhibits* ET-induced [TNF-alpha] production in vitro in human monocytes by inhibiting activation of and AP-1 by inhibiting degradation of IkappaB and mitogen activated protein kinase pathways , respectively . Positive_regulation TNF NFKB1 15350531 1292409 Using a novel model of EMT in colon carcinoma in which the inflammatory cytokine TNF-alpha accelerates this TGF-beta directed process , we report that [TNF-alpha] stimulation upregulates expression of the chemokine IL-8 , and that this upregulation is *dependent* on the transcription factor . Positive_regulation TNF NFKB1 15464079 1305006 Anti-inflammatory drugs and [tumor necrosis factor-alpha] production from monocytes : *role* of transcription factor and implication for rheumatoid arthritis therapy . Positive_regulation TNF NFKB1 15481297 1320374 *regulates* the expression of [TNF] . Positive_regulation TNF NFKB1 15481297 1320378 Because NF-kappaB is activated by both LPS and ROS , we hypothesized that an inhibitor of , pyrrolidine dithiocarbamate ( PDTC ) , would *block* release of [TNF] from the heart stimulated by these two agents . Positive_regulation TNF NFKB1 15485901 1320918 These data support a model in which [TNF-alpha] *activation* of dependent-gene expression requires nuclear relocalization of p65 as well as nuclear relocalization of SIMPL , generating a TNF-alpha-specific induction of gene expression . Positive_regulation TNF NFKB1 15501764 1327084 In this regard , the ability of LT-IIbB to activate and *induce* [TNF-alpha] and IL-8 was antagonized by the LT-IIb holotoxin . Positive_regulation TNF NFKB1 15528993 1332662 Activation of *leads* to the production of proinflammatory cytokines such as IL-12 and [TNF-alpha] that are involved in innate and adaptive immunity . Positive_regulation TNF NFKB1 15604270 1346843 In tubular LLC-PK(1) cells , *activation* of by [TNF-alpha] resulted in HIF-1alpha protein synthesis as determined by [ ( 35 ) S ] methionine pulse experiments . Positive_regulation TNF NFKB1 15662752 1350340 It became known , that oxidized LDL can inhibit LPS induced binding of the NF-kappaB to DNA and the subsequent expression of [TNF-alpha] and interleukin-1beta in macrophages as well as oxidized LDL modulates *activation* of in mononuclear phagocytes by altering the degradation of I-kappaBs . Positive_regulation TNF NFKB1 15665514 1365458 Because the endotoxin stress response in ventricular myocytes involves the upregulation of [TNFalpha] , and the *activation* of , the effects of rosiglitazone on lipopolysaccharide induced NF-kappaB dependent transcription were also investigated . Positive_regulation TNF NFKB1 15665514 1365462 Treatment of neonatal rat ventricular myocytes with 10 micromol/L rosiglitazone enhanced [TNF-alpha-] and lipopolysaccharide induced *dependent* transcription by approximately 1.8- and approximately 1.4-fold respectively , and TNF-alpha induced IL-6 secretion by n1.5-fold . Positive_regulation TNF NFKB1 15687488 1382420 Reduction of the protein level of endogenous CPAP by RNA interference resulted in decreased *activation* of by [TNFalpha] . Positive_regulation TNF NFKB1 15696609 1351619 The inhibitor , pyrrolidine dithiocarbamate ( PDTC ) , *suppressed* both IL-12 and [TNF-alpha] secretions from Mo-DCs-Tum . Positive_regulation TNF NFKB1 15698590 1372318 However , the effects of statin on the expression of [TNF-alpha] and *activation* of in endothelial cells stimulated by CRP are less studied . Positive_regulation TNF NFKB1 15698590 1372330 CRP stimulation result in induction of [TNF-alpha] and *activation* of , and this effect could be significantly inhibited by fluvastatin , suggesting that CRP may play a direct role in atherogenesis by activating endothelial cells , and statins inhibit this response , which may provide an insight into the mechanisms of anti-inflammatory or anti-atherosclerotic actions of statins . Positive_regulation TNF NFKB1 15722197 1374636 The *activation* of and phosphatidylinositol-3 (PI3) kinase by [TNF-alpha] and TRAIL overrides the pro-apoptotic effects of these ligands in carcinoma cells and hinders their therapeutic application . Positive_regulation TNF NFKB1 15722553 1396052 A microarray data set generated from a time course of [TNF] stimulation in the *presence* or absence of signaling was analyzed . Positive_regulation TNF NFKB1 15723296 1376695 In Myd88 ( -/- ) mice after PH , induction of expression of immediate early genes involved in hepatocyte replication and phosphorylation of STAT3 in the liver , and production of [TNF-alpha/IL-6] by and *activation* of in the Kupffer cells were grossly subnormal and were associated with impaired liver regeneration . Positive_regulation TNF NFKB1 15777836 1384777 This enhanced [TNF alpha] production was not *due* to changes in activation , TNF alpha transcription rates , or mRNA stability . Positive_regulation TNF NFKB1 15800781 1417377 We sought to determine whether CARD15 mediated activation can *contribute* to MDP induced [TNFalpha] production and , consequently , if polymorphisms in both genes affect the control of such induction . Positive_regulation TNF NFKB1 15800781 1417384 Transfection and electrophoretic mobility shift assays ( EMSA ) experiments in HEK293 cells demonstrated that MDP exposure stimulates [TNFalpha] gene transcription , as a *result* of CARD15 induced activation and binding to TNFalpha promoter . Positive_regulation TNF NFKB1 15870231 1439693 PAP prevented [TNF-alpha] *induced* activation in monocytic , epithelial , and endothelial cells and reduced proinflammatory cytokine mRNA levels and adhesion molecule expression . Positive_regulation TNF NFKB1 15879145 1406059 In this study we demonstrate that a highly purified low endotoxin pancreatic elastase preparation ( El-UP ) failed both to activate and to *induce* [TNF-alpha] release in RAW 264.7 cells and bone marrow derived macrophages . Positive_regulation TNF NFKB1 15913942 1465006 In comparison , LPS induced a much greater activation of and TNFalpha promoters , and [TNFalpha] secretion into the supernatant was strongly *induced* . Positive_regulation TNF NFKB1 15925386 1440380 Our observations show that calcium , MAPK activation , HIF-1alpha , and are *necessary* for ethanol induced [TNF-alpha] and TGF-beta1 expression . Positive_regulation TNF NFKB1 15938622 1415424 Inhibition of by cobrotoxin *resulted* in reductions in the LPS induced expressions of COX-2 , iNOS , cPLA(2) , IL-4 , and [TNF-alpha] in astrocytes and in COX-2 expression induced by SNP , LPS , and TNF-alpha in astrocytes . Positive_regulation TNF NFKB1 15943902 1415945 Distinct differences between [TNF] receptor 1- and TNF receptor 2-mediated *activation* of . Positive_regulation TNF NFKB1 15949909 1465024 Addition of purified NSmase to ANA-1 cell cultures stimulated binding , increased transcriptional activity in cells transfected with NFkappaB responsive promoters , and *induced* [TNFalpha] expression . Positive_regulation TNF NFKB1 15971008 1434684 Inhibition of activity with the p65-antisense or lactacystin under static condition *blocked* the expression of most of the genes that are [TNF-alpha-inducible] and shear stress-down regulated . Positive_regulation TNF NFKB1 15972840 1459051 While HT is generally thought to have anti-inflammatory and cytoprotective effects , we have previously shown that moderate in vitro HT prolongs TNF-alpha production by LPS stimulated mononuclear phagocytes , in part by prolonging [TNF-alpha] gene transcription and *activation* of the pleiotropic transcription factor . Positive_regulation TNF NFKB1 15979856 1452533 In order to study the relationship between the constitutively active NF-kappaB and IkappaB-alpha , a dominant negative mutant IkappaB-alpha ( IkappaB-alphaDN ) , lacking the N-terminal 36 amino acids required for the *activation* of by [tumor necrosis factor-alpha (TNF-alpha)] , was expressed in the Daudi cells . Positive_regulation TNF NFKB1 15980040 1465296 Taken together , these data provide compelling evidence for the *role* of signaling in [TNF-alpha] gene expression in heart and highlight the importance of this proinflammatory gene-regulatory pathway as a potential therapeutic target in the management of cytokine induced myocardial dysfunction . Positive_regulation TNF NFKB1 15994412 1447078 In Wt mice , mtDNA depletion was avoided by selective iNOS blockade , and residual mtDNA loss was linked to *dependent* [TNF-alpha] expression . Positive_regulation TNF NFKB1 16006484 1459261 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of [TNF-alpha] , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the transcription factor ( ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TNF NFKB1 16011481 1459392 [TNFalpha] *induces* ( nuclear factor kappaB ) and AP-1 ( activator protein 1 ) nuclear binding activities . Positive_regulation TNF NFKB1 16020544 1453192 [Tumor necrosis factor (TNF)] superfamily receptors typically *induce* both and JNK activation by recruiting the TRAF2 signal transduction protein to their cytoplasmic domain . Positive_regulation TNF NFKB1 16027228 1465980 We found that UVB , IL-1 , and [TNFalpha] *induced* activation and then produced MMP-1 and bFGF in HaCaT keratinocytes and skin fibroblasts . Positive_regulation TNF NFKB1 16054790 1473755 These findings demonstrate that the inhibition of the LPS/rIFN-gamma induced production of NO and [TNF-alpha] by LR *involves* the inhibition of activation . Positive_regulation TNF NFKB1 16112155 1546728 It is known that tightly *regulates* [TNF] transcription . Positive_regulation TNF NFKB1 16116965 1449126 1 h , 2 h , 4 h and 6 h after LPS injection , the *activation* of in blood mononuclear cells and the content of [TNF-alpha] and IL-6 in plasma was detected by enzyme linked immunoadsordent assay ( ELISA ) . Positive_regulation TNF NFKB1 16123045 1467034 In vivo , [TNF-alpha] *induced* as determined by whole mouse body bioluminescence . Positive_regulation TNF NFKB1 16135673 1450327 Recently , we demonstrated that 3,3',5-triiodothyronine ( T3 ) induces oxidative stress in rat liver , with enhancement in the DNA binding of nuclear factor-kappaB (NF-kappaB) and the *dependent* expression of [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF NFKB1 16271513 1518400 [TNF-alpha] *induced* maximal translocation in these T cells , indicating that they remain receptive to alternative signaling pathways , and pulsing with IL-12 prior to TCR triggering reversed their apparent anergy . Positive_regulation TNF NFKB1 16274845 1518436 Beads containing an immobilized GKPV peptide were investigated for their ability to inhibit proinflammatory [tumor necrosis factor-alpha (TNF-alpha)] stimulated *activation* of in HBL cells stably transfected with an NF-kappaB-luciferase reporter construct . Positive_regulation TNF NFKB1 16274845 1518438 Peptide functionalized beads were compared with the ability of soluble peptide alone ( alpha-MSH or GKPV ) or non functionalized beads to inhibit [TNF-alpha] stimulated *activation* of . Positive_regulation TNF NFKB1 16279946 1480585 We show that activation of PAI-1 gene by [TNFalpha] and reactive oxygen species is *mediated* by interaction of with the cis acting element located in the -675 4G/5G insertion/deletion in the PAI-1 promoter . Positive_regulation TNF NFKB1 16297883 1502767 Dioscorin also stimulated multiple signaling molecules ( , ERK , JNK , and p38 ) and *induced* the expression of cytokines ( [TNF-alpha] , IL-1beta , and IL-6 ) in murine RAW 264.7 macrophages . Positive_regulation TNF NFKB1 16301661 1485235 Lung activation and neutrophil recruitment *require* IL-1 and [TNF] receptor signaling during pneumococcal pneumonia . Positive_regulation TNF NFKB1 16385659 1494171 To determine the functional roles of TNFR1 and TNFR2 on TNF induction , we investigated activation and [TNF-alpha] *induction* after neutralizing TNFR1 and TNFR2 by an antibody treatment . Positive_regulation TNF NFKB1 16385659 1494177 We found that activation and [TNF-alpha] *induction* are blocked by TNFR1 neutralizing antibody treatments . Positive_regulation TNF NFKB1 16408291 1540223 Furthermore , the proteasome inhibitor MG-132 caused loss of IkappaBalpha , and an increase of it is phosphorylated form , but basal NF-kappaB was unchanged , whilst *activation* of by [TNFalpha] was completely inhibited , suggesting that MG-132 activity is independent of constitutive NF-kappaB activation . Positive_regulation TNF NFKB1 16420740 1514803 In contrast , the broad-spectrum tyrosine kinase inhibitor genistein and the MEK-1 inhibitor ( PD98059 ) abrogated GM-CSF priming of [TNF-alpha] release and *activation* of both and AP-1 . Positive_regulation TNF NFKB1 16426002 1515700 [Tumor necrosis factor (TNF)] production in PBMC supernatants was measured by an enzyme linked immunosorbent assay after TLR ligand stimulation and was *dependent* on gene transcription and activation . Positive_regulation TNF NFKB1 16439527 1516606 Furthermore , both ectopically expressed SV5 SH and MuV SH blocked *activation* of by [TNF-alpha] in a reporter gene assay , suggesting that both SH proteins can inhibit TNF-alpha signaling . Positive_regulation TNF NFKB1 16475830 1524165 These results suggest that [TNF alpha] suppresses apoAI promoter activity through both the MEK/ERK and JNK pathways but is not *mediated* by either p38 MAP kinase activity or activation . Positive_regulation TNF NFKB1 1649771 162930 Furthermore , [TNF] induces a set of genes and at least part of this transcriptional activation is *mediated* by . Positive_regulation TNF NFKB1 16526022 1541906 Electrophoretic mobility shift assay revealed that *activation* of induced by [TNFalpha] is down regulated by curcumin . Positive_regulation TNF NFKB1 16581045 1496462 Signal transduction studies revealed that IL-1beta and [TNF-alpha] stimulation *induced* phosphorylation in A549 cells , but antagonist inhibition of NFkappaB p50-p65 phosphorylation correlated with marked reduction of IL-1beta or TNF-alpha induced CCL28 expression . Positive_regulation TNF NFKB1 16603398 1550701 The receptor interacting protein kinase 1 ( RIP1 ) is essential for the *activation* of by [tumor necrosis factor alpha (TNFalpha)] . Positive_regulation TNF NFKB1 16611629 1568850 [TNF] *induced* a quantitatively and temporally equivalent activation of in control and E1A transfected cells . Positive_regulation TNF NFKB1 16682409 1584043 [TNF] *induced* activation in wild-type but not in NQO1 deleted cells . Positive_regulation TNF NFKB1 16688828 1560307 The enhanced iNOS activity and expression were positively correlated with the liver damage , especially the necro-inflammation , *activation* of , and [TNF-alpha] mRNA expression . Positive_regulation TNF NFKB1 16702954 1624667 Surprisingly , activated *induced* [TNF-alpha] mRNA expression in the presence of all DNA damage inducing agents . Positive_regulation TNF NFKB1 16705808 1496606 DEP induced [TNF-alpha] gene expression is *regulated* at the transcriptional level by . Positive_regulation TNF NFKB1 16751174 1605259 Consistent with the decrease in cAMP levels , ethanol led to an increase in LPS-inducible TNF-alpha production by affecting activation and *induction* of [TNF] mRNA expression , without any change in TNF mRNA stability . Positive_regulation TNF NFKB1 16751383 1570976 The RASF derived exosomes , but not exosomes derived from fibroblasts obtained from individuals with osteoarthritis , are cytotoxic for the L929 cell , a [TNF-alpha-sensitive] cell line , and stimulate *activation* of and induction of collagenase-1 in RASF . Positive_regulation TNF NFKB1 16777921 1672115 Growth hormone activated STAT5 , and directly reduced [TNFalpha] *activation* of , in T84 cells . Positive_regulation TNF NFKB1 16804400 1579572 p65 , [tumor necrosis factor-alpha] , interleukin (IL)-1beta , IL-12 , and intercellular adhesion molecule-1 were *detected* by immunohistochemical staining . Positive_regulation TNF NFKB1 16848314 1588289 The inhibitory effect of T-614 on the production of [TNFalpha] in LPS stimulated NR8383 cells may be *mediated* by suppression of activity . Positive_regulation TNF NFKB1 16858424 1625423 In HaCaT cells and in reconstructed human epidermis ( RHE ) , FasL triggered a *dependent* mRNA accumulation of inflammatory cytokines ( [tumor necrosis factor-alpha] , IL-6 , and IL-1beta ) , chemokines ( CCL2/MCP-1 , CXCL1/GROalpha , CXCL3/GROgamma , and CXCL8/IL-8 ) , and the adhesion molecule ICAM-1 . Positive_regulation TNF NFKB1 16871588 1593191 Inhibition of p38 and activation by SB203580 and pyrrolidine dithiocarbamate , respectively , *blocked* endotoxin induced H ( 2 ) O ( 2 ) , NO , [TNF-alpha] , and IL-6 synthesis . Positive_regulation TNF NFKB1 16871588 1593197 In conclusion , endotoxin induced synthesis of NO , [TNF-alpha] , and IL-6 in HSCs is *mediated* by p38 and , with involvement of H ( 2 ) O ( 2 ) in TNF-alpha production . Positive_regulation TNF NFKB1 16873280 1593284 Rhinovirus replication in human macrophages induces *dependent* [tumor necrosis factor] alpha production . Positive_regulation TNF NFKB1 16879221 1593936 Further , we provide evidence for a [TNF-alpha] *induced* binding of to the recently described kappaB site in the t-PA gene and of cyclic adenosine monophosphate response element binding protein ( CREB ) to the t-PA CRE-like site . Positive_regulation TNF NFKB1 16924232 1692174 We found that in wild-type mouse embryonic fibroblast (MEF) , [TNF] *induced* activation as measured by DNA binding but deletion of PKR abolished this activation . Positive_regulation TNF NFKB1 16936197 1608937 *Activation* of by [TNF receptor associated factor (TRAF)] 2 , TRAF6 , NF-kappaB inducing kinase , or protein kinase D , which transduce signals downstream of Toll-like receptors , TNF receptors , and free radicals , respectively , were all potent activators of the A20 promoter . Positive_regulation TNF NFKB1 16937467 1609119 [TNF-alpha] also *induced* dependent transcriptional activity in AGS cells . Positive_regulation TNF NFKB1 16939707 1666197 Differential effect of Rhizoma coptidis and its main alkaloid compound berberine on [TNF-alpha] *induced* translocation in human keratinocytes . Positive_regulation TNF NFKB1 16943688 1609809 Thalidomide downregulates *induced* [TNF-alpha] and activates hepatic stellate cells (HSC) via inhibition of IkappaB degradation to prevent liver cirrhosis . Positive_regulation TNF NFKB1 16952378 1639502 This study was designed to determine whether N-acetylcysteine (NAC) , an antioxidant , prevents the *activation* of by exogenously administered [TNF-alpha] in adipocytes , and whether such change affects the production of adipocytokines . Positive_regulation TNF NFKB1 17008396 1674092 However , [TNF] *induced* a p52/RelB DNA binding complex in p50 null MEC nuclear extracts . Positive_regulation TNF NFKB1 17010424 1666321 We investigated the production of [TNF-alpha] and the *activation* of the nuclear transcription factor . Positive_regulation TNF NFKB1 17018860 1682933 In the resting cell , RhoA suppresses Cdc42 activation , IkappaBalpha degradation , activation , and *induction* of [TNFalpha] and NF-kappaB dependent chemokines . Positive_regulation TNF NFKB1 17018860 1682939 Suppression of TNFalpha induction by RhoA is Rho kinase alpha ( ROCKalpha ) independent , but Cdc42 dependent , because TNFalpha induction by C3 transferase is attenuated by inhibition of Cdc42 , and constitutively active Cdc42 suffices to activate and *induce* [TNFalpha] . Positive_regulation TNF NFKB1 17041226 1631070 Human cytomegalovirus IE86 attenuates virus- and [tumor necrosis factor] alpha induced *dependent* gene expression . Positive_regulation TNF NFKB1 17075836 1649894 RhoA mediated , [tumor necrosis factor] alpha *induced* activation of in rheumatoid synoviocytes : inhibitory effect of simvastatin . Positive_regulation TNF NFKB1 17082635 1643347 IL-1 beta and [TNF-alpha] regulation of the adenosine receptor (A2A) expression : differential *requirement* for binding to the proximal promoter . Positive_regulation TNF NFKB1 17125270 1652860 In the present study , phenolic analogues of resveratrol and a series of substituted trans-stilbenes without hydroxy groups were compared with resveratrol for their abilities to inhibit the human [tumor necrosis factor] alpha induced ( TNF-alpha ) *activation* of , using the Panomics NF-kappaB stable reporter cell line 293/NF-kappaB-luc . Positive_regulation TNF NFKB1 17142966 1653796 [TNFalpha] stimulation *induced* the biphasic increases in expression of , ST3Gal I , FUT IV , ST3Gal IV and ST6GalNAc III mRNAs and the transient increase in expression of ST6Gal I mRNA and the decrease in ST3GalNAc IV mRNA . Positive_regulation TNF NFKB1 17185631 1717323 fMLP pretreatment also inhibited *activation* of proinflammatory transcription factor by [TNF-alpha] in Caco2bbe cells , reducing induction of NF-kappaB target genes by TNF-alpha both in human intestinal biopsies and Caco2bbe cells . Positive_regulation TNF NFKB1 17267205 1710611 The present results demonstrate that 1,25 ( OH ) ( 2 ) D ( 3 ) and 1,24 ( OH ) ( 2 ) D ( 2 ) *inhibit* [TNFalpha] expression in macrophages , by increasing IkappaBalpha and decreasing activity . Positive_regulation TNF NFKB1 17276889 1691894 These findings suggest that the inhibition of LPS induced NO formation and [TNF-alpha] production in microglia by ginsenosides is *due* to its inhibition of , which may be the mechanistic basis for the anti-inflammatory effects of ginsenosides . Positive_regulation TNF NFKB1 17303559 1718943 We find that TNF mRNA production in response to ionophore is NF-kappaB independent , but inhibition of activation *attenuates* virus- and LPS induced [TNF] mRNA levels after initial induction . Positive_regulation TNF NFKB1 17307735 1719147 Similarly , we showed by chromatin immunoprecipitation assays as well as by gel-shift assays with nuclear extracts that [TNF-alpha] *induced* binding to regions at positions -380 , -1420 , and -1890 , demonstrated its association with RNA polymerase II and cofactor proteins , and confirmed the functionality of the respective promoter regions in vivo . Positive_regulation TNF NFKB1 17321745 1711804 To elucidate the molecular mechanism of inhibition of cell adhesion molecules , we investigated the status of nuclear transcription factor-kappaB ( NF-kappaB ) and were able to establish that compound 8a significantly blocked the [TNF-alpha] induced *activation* of . Positive_regulation TNF NFKB1 17322278 1747577 [TNF-alpha] *induced* CD38 expression in human airway smooth muscle cells : role of MAP kinases and transcription factors and AP-1 . Positive_regulation TNF NFKB1 17349210 1708021 Electrophoretic mobility shift assay ( EMSA ) revealed that [TNF-alpha] *induced* transactivation in AML14 cells in a time- and dose dependent fashion , and subsequent supershift assays indicated that the translocated NF-kappaB was the heterodimer p65 ( RelA)/p50 . Positive_regulation TNF NFKB1 17409010 1736167 Previous studies indicated that activation by tumor necrosis factor (TNF) receptor family , which *activates* [TNF receptor associated factor (TRAF)] , induces HIV-1 expression . Positive_regulation TNF NFKB1 17420011 1668204 The mutant penta acylated LPS from the lpxM-strain did not induce [TNF-alpha] production in murine peritoneal macrophages , or *activation* of in transfected cells expressing murine TLR4/MD-2 . Positive_regulation TNF NFKB1 17434489 1729012 We also observed that is *involved* in AGE-BSA induced [TNF-alpha] . Positive_regulation TNF NFKB1 17473434 1738340 These findings demonstrate that the inhibition of the LPS/rIFN-gamma induced production of NO and [TNF-alpha] by MC is *due* to the inhibition of activation . Positive_regulation TNF NFKB1 17485223 1750543 *Activation* of by [TNF-alpha] was also abolished by preincubation of HSC with GSH , but not by deferoxamine , tempol or trolox . Positive_regulation TNF NFKB1 17532082 1778387 Further experiments showed that IL-6 and [TNF-alpha] production were *dependent* on , which was activated through I-kappaBalpha degradation . Positive_regulation TNF NFKB1 17550447 1752579 Abnormal nuclear factor (NF)-kappaB signal pathway and aspirin inhibits [tumor necrosis factor] alpha *induced* activation in keloid fibroblasts . Positive_regulation TNF NFKB1 17550447 1752585 In this study , we demonstrate that [TNF-alpha] *induced* activation in keloid fibroblasts , which show more sensitively than the normal skin fibroblasts . Positive_regulation TNF NFKB1 17551258 1785776 Exposure to Ang II ( 10 ( -6 ) M for 24 h ) also enhanced intracellular ROS elaboration and the levels of [tumor necrosis factor (TNF)-alpha] and interleukin (IL)-8 , upregulated chemokine receptor CXCR2 mRNA expression , increased adhesion of endothelial cells to monocytes and *induced* a significant increase in the activity of , which was attenuated by pretreatment with the Ang II receptor blocker losartan ( 1 , 3 and 10 muM ) . Positive_regulation TNF NFKB1 17553937 1792002 Twenty-four hours thereafter , splenic macrophages were isolated , and their IL-6 and [TNF-alpha] production and *activation* of MAPK and were measured . Positive_regulation TNF NFKB1 17567906 1763216 Functionally , transiently overexpressed Zfra sequestered ( p65 ) , WOX1 , p53 and phospho-ERK ( extracellular signal activated kinase ) in the cytoplasm , and [TNF] or UV light could not effectively *induce* nuclear translocation of these proteins . Positive_regulation TNF NFKB1 17583675 1764198 Rosiglitazone attenuates *dependent* ICAM-1 and [TNF-alpha] production caused by homocysteine via inhibiting ERK1/2/p38MAPK activation . Positive_regulation TNF NFKB1 17644514 1793196 The compounds also inhibited *dependent* [tumor necrosis factor-alpha] mRNA up-regulation . Positive_regulation TNF NFKB1 17660390 1799068 [TNF-alpha] *induced* and RhoA activation and upregulation of adhesion molecules ICAM-1 and VCAM-1 , increased expression of monocyte chemoattractant protein , enhanced transendothelial migration of monocytes , and augmented monocyte-endothelial adhesion . Positive_regulation TNF NFKB1 17669364 1780500 Artemisolide is a typical inhibitor of IkappaB kinase beta targeting cysteine-179 residue and down-regulates *dependent* [TNF-alpha] expression in LPS activated macrophages . Positive_regulation TNF NFKB1 17669364 1780502 Further , we demonstrate that ATM down-regulates *dependent* [TNF-alpha] expression . Positive_regulation TNF NFKB1 17673150 1777271 Virulizin also induced the phosphorylation of IkappaB , suggesting that induction of [TNFalpha] expression by Virulizin is *mediated* by activation of . Positive_regulation TNF NFKB1 17705188 1783020 Expression of M suppressed [tumor necrosis factor alpha (TNF-alpha)] *induced* activation using a luciferase reporter assay . Positive_regulation TNF NFKB1 17763449 1801855 Furthermore , APC directly suppressed the production of [tumor necrosis factor (TNF)] and the *activation* of and MAP kinase p38 , and inhibitors of NF-kappaB or p38 reduced the production of MMP-9 , suggesting that APC inhibits MMP-9 by blocking TNF , NF-kappaB , and p38 . Positive_regulation TNF NFKB1 17785857 1790830 Zinc dependent suppression of [TNF-alpha] production is *mediated* by protein kinase A-induced inhibition of Raf-1 , I kappa B kinase beta , and . Positive_regulation TNF NFKB1 17828497 1795609 To investigate the *role* of in [TNF-alpha] induced apoptosis in HSC-T6 , a mutant IkappaBalpha was transfected into HSC-T6 cells by lipofectin transfection technique and its transient effect was examined 48 h after the transfection . Positive_regulation TNF NFKB1 17855547 1818136 VZV also *inhibits* icam-1 stimulation of [TNF-alpha] by strongly reducing nuclear translocation in MRC5 fibroblasts . Positive_regulation TNF NFKB1 17878383 1797031 Activation of , STAT6 , and STAT1 was *induced* in eosinophils by [TNF-alpha] , IL-4 , and IFN-gamma , respectively . Positive_regulation TNF NFKB1 17898021 1849059 Furthermore , the increased synthesis of IL-6 and [TNF-alpha] by anionic pIgA in HMC was significantly diminished ( P < 0.01 ) in the *presence* of inhibitor pyrrolidine dithiocarbamate and NF-kappaB blocking permeable peptides SN50 ( P < 0.01 ) . Positive_regulation TNF NFKB1 17936907 1844355 Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli , but S. aureus fails to both activate in mammary epithelial cells and to quickly *induce* [TNFalpha] and interleukin-8 ( CXCL8 ) expression in the udder . Positive_regulation TNF NFKB1 17964662 1831056 Taken together , these results suggest that linomide *inhibits* [TNF-alpha] production by suppressing the activation of and mitogen activated protein kinase (MAPK) , which might , at least in part , contribute to the beneficial effects of linomide in the treatment of autoimmune diseases . Positive_regulation TNF NFKB1 18022363 1827536 In sensitive tumor lines , IAP antagonist induced *stimulated* production of [TNFalpha] that killed cells in an autocrine fashion . Positive_regulation TNF NFKB1 18022363 1827538 Inhibition of *reduced* [TNFalpha] production , and blocking NF-kappaB activation or TNFalpha allowed tumor cells to survive IAC induced apoptosis . Positive_regulation TNF NFKB1 18040799 1669144 *Activation* of by [TNF-alpha] and inhibition of TNF-alpha induced BDNF expression by Deltap65 ( a dominant negative mutant ) and NEMO binding domain peptide ( an inhibitor of NF-kappaB ) suggests that TNF-alpha induces BDNF expression through the activation of NF-kappaB . Positive_regulation TNF NFKB1 18081698 1882960 This revealed that the LPS- and [TNF-inducible] expression of ABIN-3 is *dependent* on the binding of to a specific B site in the ABIN-3 promoter . Positive_regulation TNF NFKB1 18089811 1834824 These findings show that the reduced bystander response in A549 cells is due to *activation* of signaling by [TNF-alpha] , whereas enhanced response to IR-induced bystander signaling in H460 cells was due to release of TRAIL associated with nuclear translocation of PAR-4 . Positive_regulation TNF NFKB1 18177902 1856271 Avarol inhibited [tumor necrosis factor-alpha (TNF-alpha)] generation in stimulated human monocytes ( IC ( 50 ) 1 microM ) and TNF-alpha induced *activation* of binding in keratinocytes . Positive_regulation TNF NFKB1 18218230 1839131 The expression of NF-kappaB and [TNFalpha] *induced* by play an important role in the pathogenesis of pneumonia . Positive_regulation TNF NFKB1 18235000 1864345 [TNF-alpha] *induced* the phosphorylation and downregulation of IkappaB-alpha and the translocation of the p65 subunit of to the nucleus . Positive_regulation TNF NFKB1 18381653 1913014 Regulation of both EAAT-1 and EAAT-2 is mediated by , and this transcriptional regulator is also *required* for increased production of [TNFalpha] . Positive_regulation TNF NFKB1 18393939 1913457 In conclusion , we find that can *regulate* basal [TNFalpha] and , in certain circumstances , the hypoxia induced HIF-1alpha . Positive_regulation TNF NFKB1 18420487 1926128 Exposure of HRECs to 25 mmol/l glucose did not stimulate endogenous ROS production , *activation* of , extracellular signal related kinase ( ERK ) , p38 and Jun NH ( 2 ) -terminal kinase ( JNK ) , tyrosine phosphorylation , interleukin (IL)-1beta , or [tumor necrosis factor-alpha (TNF-alpha)] production and only slightly affected apoptotic cell death pathways compared with normal glucose ( 5 mmol/l ) . Positive_regulation TNF NFKB1 18433103 1920788 It was previously demonstrated that stevioside attenuates *dependent* [TNF-alpha] and IL-1beta synthesis in LPS stimulated monocytes . Positive_regulation TNF NFKB1 18442881 1938507 [TNF] via TNFR1 axis *induces* , and may contribute to inflammation facilitated neoplasia . Positive_regulation TNF NFKB1 18450452 1908453 Knockdown of CARP-2 stabilized TNFR1 associated polyubiquitinated RIP levels after [TNF] simulation and enhanced *activation* of . Positive_regulation TNF NFKB1 18461339 1979041 Furthermore , cells treated with avenanthramides showed a significant inhibition of [tumor necrosis factor-alpha (TNF-alpha)] *induced* luciferase activity and subsequent reduction of interleukin-8 (IL-8) release . Positive_regulation TNF NFKB1 18463678 1971656 Employing a series of in vitro and in cellulo approaches , we have demonstrated that in primary human keratinocytes ( i ) [TNF-alpha] rapidly *induces* ROS generation , IkappaB degradation , p65 nuclear translocation , and ultimately production of inflammatory cytokines ; Positive_regulation TNF NFKB1 18547651 1940568 The activation of was *followed* by increased mRNA expression of [TNF-alpha] and IL-1beta peaking at about 20 h . Positive_regulation TNF NFKB1 18569074 1929848 The cellular secretion of TNF-alpha , IL-1beta , IL-6 , NO and IL-10 in supernatant , mRNA expression of [TNF-alpha] , COX-2 , iNOS and HO-1 , protein expression of COX-2 and HO-1 , and *activation* of were assayed by ELISA , the Griess method , real-time quantitative PCR , and Western blot and immunocytochemistry method , respectively . Positive_regulation TNF NFKB1 18599158 2208592 and ( 3 ) S100B/RAGE induced upregulation of COX-2 , IL-1beta and [TNF-alpha] expression *requires* the concurrent activation of and AP-1 . Positive_regulation TNF NFKB1 18637177 1942039 We have used this technique to quantitatively characterize *activation* of the transcription factor by the cytokine [TNF-alpha] . Positive_regulation TNF NFKB1 18641359 1937756 The presence of the PDE4 inhibitor rolipram reduces the [TNF-alpha] production and the *activation* of the three complexes . Positive_regulation TNF NFKB1 18662886 1972996 [TNF-alpha] *induced* rapid activation in both HT-29 and FHC cell lines and this effect was differently modulated by NaBt in these two cell lines . Positive_regulation TNF NFKB1 18687753 1973593 Our recent studies showed that chronic ethanol exposure significantly decreased cellular cAMP levels in both LPS stimulated and unstimulated monocytes and Kupffer cells , leading to an increase in LPS-inducible TNF-alpha production by affecting activation and *induction* of [TNF] mRNA expression . Positive_regulation TNF NFKB1 18697935 1950337 The cellular inhibitor of apoptosis 1 and 2 ( cIAP1 and cIAP2 ) proteins have been implicated in the *activation* of by [TNFalpha] ; however , genetic deletion of either cIAP1 or 2 did not support a physiologically relevant role , perhaps because of functional redundancy . Positive_regulation TNF NFKB1 18753141 1980019 [Tumor necrosis factor-alpha] *induced* the maximal S100A6 promoter and transcription factor ( p65 subunit ) . Positive_regulation TNF NFKB1 18804339 2099791 We also determined the expression of TLR4 mRNA and MyD88 mRNA by in situ hybridization ( ISH ) , the *activation* of by EMSA , and the expression of [TNF-alpha] protein by Western blot . Positive_regulation TNF NFKB1 18804339 2099795 The expression of TLR4 mRNA and MyD88 mRNA , the *activation* of , and the expression of [TNF-alpha] protein showed clear difference as well . Positive_regulation TNF NFKB1 18832697 1971194 Glucocorticoid induced [TNF] receptor expression by T cells is reciprocally *regulated* by and NFAT . Positive_regulation TNF NFKB1 18996370 2016016 Inhibition of NF-kappaB activity by short interfering RNA mediated knock-down of p65 impairs , while *activation* of activity by [TNF-alpha] synergizes induction of NF-kappaB target genes by LMX1B . Positive_regulation TNF NFKB1 19023660 2035111 This study examines the *role* of in the regulation of [TNFalpha] production by morphine in microglia . Positive_regulation TNF NFKB1 1905804 161650 Our results suggest that maximal transcriptional activation of the uPA gene by PMA , IL-1 and [TNF alpha] *requires* the induction of activity and the decay of a short lived repressor protein , possibly IkB . Positive_regulation TNF NFKB1 19067146 2024073 The TNBS treatment caused colon shortening , increased myeloperoxidase activity , *induced* IL-1beta , [TNF-alpha] , and IL-6 expression in the colon , activated , and potentiated the GAG degrading activities of intestinal microflora . Positive_regulation TNF NFKB1 19088456 2003736 ( 2 ) [TNF] induced *upregulation* of promoter activity by nuclear translocation ; Positive_regulation TNF NFKB1 19096114 2003921 To test this hypothesis , we studied the effect of CoQ10 on the *dependent* pro-inflammatory cytokine [TNF-alpha] . Positive_regulation TNF NFKB1 19151401 2079184 PolyI : C , flagellin , or [TNF-alpha] also *induced* p65 protein nuclear translocation . Positive_regulation TNF NFKB1 19271152 2106013 Ang II upregulates the expression of TLR4 by RPMCs , resulting in enhanced signaling and *induction* of CD40 , [TNF-alpha] , and IL-6 expression . Positive_regulation TNF NFKB1 19273239 2045829 *Activation* of by [TNF-alpha] , up-regulates the expression of molecules which are involved in inflammation and cell adhesion . Positive_regulation TNF NFKB1 19284955 2046499 [TNF-alpha] ( 1 microg/L ) strongly *induced* the expression of by approximately 1.76-fold compared with the control in the nuclei of A549 cells , and the induced NF-kappaB expression was significantly suppressed by addition of Feiyanning ( P < 0.01 ) . Positive_regulation TNF NFKB1 19286451 2072936 Our findings suggest that can *mediate* induction of COX-2 , [TNFalpha] and astrogliosis in APPswe/PS1dE9 mice . Positive_regulation TNF NFKB1 19287189 2046611 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Positive_regulation TNF NFKB1 19369349 2088997 PKR dependent activation of p38 and NF-kappaB was required for vaccinia virus induced INHBA expression , whereas induction of [TNF-alpha] *required* only PKR dependent activation . Positive_regulation TNF NFKB1 19379593 2065653 It is concluded that the [TNF-alpha] *induces* expressions of IL-8 mRNA , MCP-1 mRNA and NF-kappaB in HUVECs , and activities signal pathway may play a role in IL-8 mRNA and MCP-1 mRNA expressions . Positive_regulation TNF NFKB1 19393188 2070139 These results indicate that canonical signaling is *required* for [TNF] induction of the notch ligand jagged-1 in EC . Positive_regulation TNF NFKB1 19479048 2085737 [TNFalpha] signaling is *mediated* by the transcription factor , , which regulates genes controlling several physiological processes including the innate immune responses , cell death , and inflammation . Positive_regulation TNF NFKB1 19514995 2092716 MW *inhibited* secretion of [TNF-alpha] , IL-6 , and IL-8 possibly by inhibiting activation . Positive_regulation TNF NFKB1 19596777 2122946 While activation of was *essential* for heat inactivated S. aureus induced [TNF-alpha] and NO , inhibiting GSK-3beta blocked heat inactivated S. aureus induced NF-kappaB p65 nuclear translocation . Positive_regulation TNF NFKB1 19620400 2137537 Endothelial blockade prevented LPS down-regulation of endothelial protein C receptor (EPCR) and thrombomodulin protein expressions , *inhibited* tissue [tumor necrosis factor-alpha] converting enzyme activity , reduced EPCR shedding , and restored plasma protein C level . Positive_regulation TNF NFKB1 19640904 2138166 This indicated that PPAR-alpha attenuated renal I/R injury via *induced* [TNF-alpha] overexpression . Positive_regulation TNF NFKB1 19640904 2138169 Taken together , our results demonstrate for the first time that prostacyclin induces the translocation of PPAR-alpha from the cytosol into the nucleus and attenuates *induced* [TNF-alpha] activation following renal I/R injury . Positive_regulation TNF NFKB1 19683526 2132969 It was further observed that inhibitor but not c-Jun N-terminal kinase inhibitor ( SP600125 ) *suppressed* [TNF-alpha] expression . Positive_regulation TNF NFKB1 19689081 2126518 The results suggested LPS might activate in peritoneal macrophages and *induce* the increase of transcription and expression of [TNF-alpha] , IL-1beta , IL-6 genes ; Positive_regulation TNF NFKB1 19699180 2139089 The most ancient part , lipid A is crucial in evoking immediate [TNF] release and *activation* of . Positive_regulation TNF NFKB1 19721818 2133738 In vitro studies with the ester dimethyl fumarate ( DMF ) described an inhibitory effect on *dependent* transcription of [tumor necrosis factor-alpha (TNF-alpha)] induced genes in human endothelial cells . Positive_regulation TNF NFKB1 19726342 2134028 [TNF-alpha] *induced* the activation of and increased the expressions of IL-6 and sICAM-1 in HUVECs . Positive_regulation TNF NFKB1 19751407 2135261 We recently reported that the nucleocapsid ( N ) protein of HFRS causing Hantaan virus ( HTNV ) inhibits [tumor necrosis factor-alpha (TNF-alpha)] *activation* of . Positive_regulation TNF NFKB1 19751407 2135263 We found that like HTNV N , the N proteins of HFRS causing Seoul and Dobrava viruses inhibited [TNF-alpha] *activation* of and translocation of the NF-kappaB p65 subunit , but did not interfere with degradation of inhibitor of NF-kappaB ( IkappaB ) . Positive_regulation TNF NFKB1 19751407 2135265 In contrast , the HFRS causing Puumala virus and the HPS causing Andes and Sin Nombre viruses did not prevent [TNF-alpha] *activation* of or nuclear translocation of p65 . Positive_regulation TNF NFKB1 19763702 2175970 High fat diet increased hepatic levels of SREBP-1c , TLR4 , [TNF-alpha] , and IL-6 protein and mRNA and increased *activation* of . Positive_regulation TNF NFKB1 19801900 2148231 Vaspin did not inhibit the [TNF-alpha] ( 20 min ) *activation* of JNK , p38 and , but only slightly inhibited Akt . Positive_regulation TNF NFKB1 1986224 152164 The *activation* of activities ( called NF-kappa B ) by [tumor necrosis factor alpha (TNF alpha)] and the phorbol ester phorbol 12-myristate 13-acetate ( PMA ) were compared . Positive_regulation TNF NFKB1 1986224 152170 We suggest that cell-specific differences in the protein kinase C-dependent activation of NF-kappa B may exist and that [TNF alpha] and PMA may *induce* expression of the gene ( s ) encoding . Positive_regulation TNF NFKB1 19874203 2258359 We investigated the effects of EPA on differentiation of RAW264.7 monocyte/macrophage cells induced by receptor activator of NF-kappaB ligand ( RANKL ) and on *activation* of by [tumor necrosis factor alpha (TNF-alpha)] or exposure to modeled weightlessness . Positive_regulation TNF NFKB1 20045454 2205377 The *activation* of by [TNF] was completely blocked by a Lagerstroemia speciosa extract in a dose- and time dependent manner in H9c2 cells . Positive_regulation TNF NFKB1 20051532 2225366 Pharmacologic inhibition of signaling with SN50 *prevented* both [TNF-alpha] release and Mrp1 expression changes in astrocytes triggered with gp120 ; Positive_regulation TNF NFKB1 20052674 2211736 *Activation* of by [TNFalpha] enhances p50/RelA binding to the NF-kappaB binding sites . Positive_regulation TNF NFKB1 20185819 2236859 In contrast , *activation* of by [TNF] did not depend on TRAF3 levels . Positive_regulation TNF NFKB1 20205746 2229737 [TNF-alpha] significantly *induced* phosphorylation of at Ser 536 and Ser 468 , but not at Ser 529 or Ser 276 . Positive_regulation TNF NFKB1 20205746 2229766 These results strongly suggest that [TNF-alpha] *induces* IL-6 synthesis through the JAK/STAT3 pathway in addition to p38 MAP kinase and SAPK/JNK in C6 glioma cells , and that phosphorylation of at Ser 536 and Ser 468 , and NADPH oxidase are involved in TNF-alpha stimulated IL-6 synthesis . Positive_regulation TNF NFKB1 20206688 2243316 The *dependent* gene expression of IL8 , IL6 , PTGS2/COX2 , [TNF] and IL33 in directly irradiated human skin fibroblasts produced the cytokines and prostaglandin E2 ( PGE2 ) with autocrine/paracrine functions , which further activated signaling pathways and induced NF-kappaB dependent gene expression in bystander cells . Positive_regulation TNF NFKB1 20220144 2249434 As IL-17 stimulation stabilizes the IkappaB-zeta transcript , we propose a model where [TNF-alpha] *induces* activation and binding of to the promoters of both NFKBIZ and LCN2 genes but induce only transcription of IkappaB-zeta . Positive_regulation TNF NFKB1 20353839 2273286 *Activation* of by fluid shear stress , but not [TNF-alpha] , requires focal adhesion kinase in osteoblasts . Positive_regulation TNF NFKB1 20353839 2273292 Interestingly , FAK was not required for [TNF-alpha] *induced* activation in osteoblasts . Positive_regulation TNF NFKB1 20356387 2255198 Moreover , we explored the mechanism governing the expression of ATX in hepatoma cells and established a critical *role* of in basal and [TNF-alpha] induced ATX expression . Positive_regulation TNF NFKB1 20363280 2261069 Further studies revealed that EC extracts suppress the production of [tumor necrosis factor-alpha (TNF-alpha)] and *activation* of . Positive_regulation TNF NFKB1 20367887 2245074 Our data demonstrate that MA can potentiate the anti-tumor activities of [TNFalpha] and *inhibit* pancreatic tumor growth and invasion by activating caspase dependent apoptotic pathway and by suppressing activation and its downstream gene expression . Positive_regulation TNF NFKB1 20385167 2267201 Also , 1alpha,25 ( OH ) ( 2 ) D ( 3 ) did not suppress the *activation* of by [TNFalpha] or PHA . Positive_regulation TNF NFKB1 20499049 2276448 The results obtained from this study revealed that CTB glycoprotein ( 100 microg/ml ) inhibits the translocation of PKC from cytosol to the membrane , the phosphorylation of p38 MAPK , the *activation* of , and the expression levels of [TNF-alpha] and IL-6 . Positive_regulation TNF NFKB1 20499049 2276516 Taken together , the results in this study suggest that CTB glycoprotein *inhibits* the expression of allergic inflammation related cytokines ( [TNF-alpha] and IL-6 ) by blocking and p38 kinase in BPA induced HMC-1 cells . Positive_regulation TNF NFKB1 20514534 2289505 These results link the gliadin derived peptides induced [TNFalpha] production through cAMP dependent PKA activation , where ion channels controlling calcium influx into cells could play a protective role , and *requires* activation . Positive_regulation TNF NFKB1 20529958 2289642 In contrast , *activation* of by [TNF-alpha] was not affected . Positive_regulation TNF NFKB1 2056282 162024 Therefore , [TNF-alpha] mRNA induction by PMA , like its induction by virus and LPS , is not primarily *mediated* by , but rather is mediated through other sequences and protein factors . Positive_regulation TNF NFKB1 20566376 2302594 The results show that CSE resulted in increasing IL-8 , IL-6 and [TNF-alpha] expression and *activation* of . Positive_regulation TNF NFKB1 20599720 2290813 In addition to Ca2+ mobilization through the IP3-receptor , TRPV2 mediated intracellular Ca2+ mobilization is involved in *dependent* [TNFalpha] and IL-6 expression , while extracellular Ca2+ entry is involved in NFkappaB independent IL-6 production . Positive_regulation TNF NFKB1 2065663 162375 NAC and other thiol compounds also blocked the *activation* of by cycloheximide , double stranded RNA , calcium ionophore , [TNF-alpha] , active phorbol ester , interleukin-1 , lipopolysaccharide and lectin . Positive_regulation TNF NFKB1 20692239 2312037 We also observed that hCMEC/D3 cells exhibit functional expression of alternative cytokine signal transduction pathways ( i.e . [TNF-alpha] mediated *activation* of ) . Positive_regulation TNF NFKB1 20729202 2335711 Synergistic *activation* of by bacterial chemoattractant and [TNF{alpha] } is mediated by p38 MAPK dependent RelA acetylation . Positive_regulation TNF NFKB1 21283748 2387859 Here we report that human monocytes treated with SEA , SEB , or anti-MHC class II monoclonal antibodies up regulated MyD88 expression , induced *activation* of , and increased expression of IL-1R1 accessory protein , [TNF-a] and IL-1ß . Positive_regulation TNF NFKB1 21502320 2434836 The interferon-gamma induced GTPase , mGBP-2 , *inhibits* [tumor necrosis factor alpha (TNF-alpha)] induction of matrix metalloproteinase-9 (MMP-9) by inhibiting and Rac protein . Positive_regulation TNF NFKB1 22339724 2560749 Results indicate that these Hb solutions have different effects on stabilization and nuclear translocation of hypoxia-inducible factor (HIF)-1 alpha , induction of the erythropoietin (EPO) gene , *activation* of , and expression of the anti-erythropoietic [agents-tumor necrosis factor-alpha] and transforming growth factor-beta 1 . Positive_regulation TNF NFKB1 2279003 147437 Additionally , our data show that both dsRNA and LPS , as well as [TNF-alpha] itself , rapidly *induce* , a DNA binding protein implicated in regulation of gene expression . Positive_regulation TNF NFKB1 23734186 2796950 This increased secretion of [TNF-alpha] and IL-6 and *activation* of , ERK , and JNK was significantly inhibited by the addition of either mannan or mannose . Positive_regulation TNF NFKB1 7544915 318435 TRAF2 mediated *activation* of by [TNF] receptor 2 and CD40 . Positive_regulation TNF NFKB1 7578992 333410 Since induction of AP-1 , IRF-1 and IRF-2 as well as NF-GMa proceeds through translational event , the posttranslational [TNF/LT-driven] *activation* of remains the only cellular event identified so far that serves as a direct target in their signaling cascade . Positive_regulation TNF NFKB1 7622526 315877 Electrophoretic mobility shift assays demonstrated that *activation* of by L-NMA , ox-LDL , and [TNF alpha] was attenuated by GSNO and SNP , but not by glutathione or cGMP analogues . Positive_regulation TNF NFKB1 7635431 317120 Using primary cultures of rat Kupffer cells the *role* of and activator protein 1 (AP-1) in the expression of the [tumor necrosis factor-alpha (TNF-alpha)] gene by lipopolysaccharide (LPS) was investigated . Positive_regulation TNF NFKB1 7636259 317441 Our studies indicate that MV , [TNF-alpha] , or PIPC *induces* ( p50 and p65 subunits ) binding to positive regulatory domain II in the glioma cell line . Positive_regulation TNF NFKB1 7681592 214296 Transcriptional activation of the HIV long terminal repeat and subsequent increase in virus production are linked to [TNF] *activation* of the cellular transcription factor . Positive_regulation TNF NFKB1 7737374 305529 [TNF] *induced* the activation of a nuclear transcriptional factor , , equally in both young and senescent cells , which indicates the lack of a defect in the early events of TNF signal transduction in senescent fibroblasts . Positive_regulation TNF NFKB1 7848678 286666 Our results suggest that [TNF-alpha] stimulation of HIV-1 gene expression in primary cultures of human fetal glial cells is *mediated* by an increase in binding of ( p50/p65 ) to the HIV-1 LTR . Positive_regulation TNF NFKB1 7913275 262071 HIV-1 expression was activated from J delta K cells by treatment with phorbol myristate acetate ( PMA ) , sodium butyrate ( NaB ) , or hexamethylene bisacetamide ( HMBA ) , but not tumor necrosis factor alpha (TNF-alpha) , confirming the *role* of in mediating [TNF-alpha] induction of HIV transcription . Positive_regulation TNF NFKB1 7964161 279448 However , our recent study showed that the activation is *induced* by [IL-1/TNF] in fibroblasts from patients with type A Niemann-Pick disease , with acid SMase deficiency . Positive_regulation TNF NFKB1 7964161 279456 This finding implies that acid SMase activity is not essential for the *activation* of by [IL-1/TNF] at least in fibroblasts . Positive_regulation TNF NFKB1 8043432 266857 Here we have used an electrophoretic mobility shift assay to show that [TNF] *induced* in malignant cells isolated from 3/3 HCL and 15/15 B-CLL patients . Positive_regulation TNF NFKB1 8051093 267597 In HeLa cells , [tumor necrosis factor alpha (TNF-alpha)] *induced* activity . Positive_regulation TNF NFKB1 8074713 270565 In human astrocytoma and neuroblastoma cell lines [tumour necrosis factor alpha (TNF alpha)] and interleukin 1 beta (IL-1 beta) *induced* and an additional KB-specific protein of approximately 80 K to bind the HIV-1 enhancer . Positive_regulation TNF NFKB1 8076691 270634 Bcl-2 protects from oxidative damage and apoptotic cell death without interfering with *activation* of by [TNF] . Positive_regulation TNF NFKB1 8076691 270638 However , Bcl-2 had no effect on the *activation* of by [TNF] , even though it protected cells from TNF induced apoptosis . Positive_regulation TNF NFKB1 8132572 251555 Increasing ceramide levels by the addition of short chain ceramides or the use of a glucosylceramide synthase inhibitor can be dissociated from *activation* of by [TNF-alpha] . Positive_regulation TNF NFKB1 8152812 253058 *Activation* of multiple DNA binding complexes by [tumor necrosis factor] . Positive_regulation TNF NFKB1 8207213 261387 Recent studies demonstrate that the sphingomyelinase-ceramide pathway plays a potential role in the *activation* of by [TNF-alpha] . Positive_regulation TNF NFKB1 8207213 261391 This data suggests that although ceramide and 1,2-diacylglycerol ( DAG ) pathways may contribute to [TNF-alpha] *activation* of , impedance of these pathways does not block TNF-alpha from activating NF-kappa B nor induction of the functional activation of the NF-kappa B responsive reporter construct , HCMV . Positive_regulation TNF NFKB1 8264646 247038 In Hs294T cells , gel shift analyses indicate that IL-1 and [TNF alpha] *induce* complex formation ; Positive_regulation TNF NFKB1 8376408 229927 As shown previously , [TNF] ( 1 nM ) *induced* a marked increase in nuclear binding in human leukemia ( HL-60 ) cells within 5 min , and elevated binding was detected for as long as 1 h. Addition of a maximally effective concentration of sphingomyelinase , 0.1 units . ml-1 , induced a 50 % reduction in sphingomyelin content by 5 min from a basal level of 560 pmol.10 ( 6 ) cells-1 and a quantitative increase in ceramide levels from 89 pmol.10 ( 6 ) cells-1 . Positive_regulation TNF NFKB1 8555009 340104 TPCK , a I kappa-B alpha protease inhibitor , was able to virtually abolish UV-induced TNF release , indicating that UV-induced [TNF] release *requires* activation . Positive_regulation TNF NFKB1 8612692 353278 [TNFalpha] *induces* a rapid and transient activation of in WEHI 164 cells which is followed by a second , long lasting phase in which the amount of NF-kappaB complex in the nucleus remains at about 50 % of maximum . Positive_regulation TNF NFKB1 8612692 353282 Calphostin C , on the other hand , can block the *activation* of by [TNFalpha] , also blocking its proteolytic degradation . Positive_regulation TNF NFKB1 8626413 355699 Furthermore , *activation* of by [tumor necrosis factor-alpha] also results in repression of PR , while PR is able to repress tumor necrosis factor-alpha induced NF-kappaB activity . Positive_regulation TNF NFKB1 8798400 381444 These results indicate that TNF-alpha induced [TNF-alpha] gene expression in astrocytes *involves* p50 and p65 proteins binding to downstream NF-kappaB sites and concomitant modulation of the chromatin structure . Positive_regulation TNF NFKB1 8799159 381938 Our results show that the *activation* of by [tumor necrosis factor (TNF)] is completely blocked by CAPE in a dose- and time dependent manner . Positive_regulation TNF NFKB1 8805640 382273 Overall , our results clearly demonstrate that the *activation* of and cytotoxicity by [TNF] is differentially regulated through the p60 receptor . Positive_regulation TNF NFKB1 8822344 384836 HTLV-I tax protein and [TNF-alpha] *induced* activation of in apoptotic MC3T3-E1 cells . Positive_regulation TNF NFKB1 8832978 385880 Our data suggest that TNF-alpha induces expression of proinflammatory cytokines such as IL-8 and MCP-1 through generation of reactive oxygen intermediates and subsequent activation of NF-kappa B in human synovial cells , and the antioxidants may inhibit , at least in part , the *activation* of by [TNF-alpha] . Positive_regulation TNF NFKB1 8864119 388930 The *activation* of the transcription factor by [tumor necrosis factor (TNF)] , ionizing radiation , or daunorubicin ( a cancer chemotherapeutic compound ) , was found to protect from cell killing . Positive_regulation TNF NFKB1 8892903 392255 Nevertheless , the simian EBV LMP1s retain most functions in common with EBV LMP1 , including the ability to induce activity in human cells , to bind the tumor necrosis factor associated factor 3 ( TRAF3 ) in vitro , and to *induce* expression of [tumor necrosis factor-responsive] genes , such as ICAM1 , in human B lymphocytes . Positive_regulation TNF NFKB1 8900181 393435 Synergistic activation of interleukin-8 gene transcription by all-trans-retinoic acid and [tumor necrosis factor-alpha] *involves* the transcription factor . Positive_regulation TNF NFKB1 8940176 399121 [Tumor necrosis factor-alpha] and interferon-gamma *induced* ( p50/p65 ) and STAT-1 , respectively , as assessed by gel shift assays . Positive_regulation TNF NFKB1 9042860 416130 We also show that *activation* of by [TNFalpha] depends on CDC42 and RhoA , but not Rac-1 proteins , because this activity is drastically inhibited by their respective dominant negative mutants . Positive_regulation TNF NFKB1 9060638 417783 Under the same conditions , Ad infection did not inhibit TNF induced phosphorylation of cPLA2 or [TNF] *activation* of . Positive_regulation TNF NFKB1 9065470 418208 The activation of NF-kappaB by fMLF appeared to be cell-specific and different from the *activation* of by [tumor necrosis factor-alpha (TNFalpha)] . Positive_regulation TNF NFKB1 9079634 420542 *Role* of in [tumor necrosis factor-alpha] and interleukin-1beta regulation . Positive_regulation TNF NFKB1 9160673 431734 The stimulatory effect of PTX on the immediate early ( IE ) enhancer/promoter was mediated via CREB/ ATF , a eukaryotic transcription factor that binds to the 19 bp sequence motif in the enhancer region , while [TNF alpha] stimulation was *mediated* by activation of the transcription factor and its binding to the 18 bp sequence motif in the enhancer . Positive_regulation TNF NFKB1 9224415 442943 Inhibition of activity by these agents also *prevented* [TNF] mRNA expression and TNF production induced by LPS . Positive_regulation TNF NFKB1 9227470 443238 A redox-sensitive nuclear factor , , *induces* transcription of [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-6 (IL-6) in macrophages . Positive_regulation TNF NFKB1 9244310 446238 Activation of the transcription factor NF-kappaB by [tumor necrosis factor (TNF)] and interleukin-1 (IL-1) *requires* the . Positive_regulation TNF NFKB1 9275204 450672 The associates with TRAF2 and *mediates* [TNF] activation of NF-kappaB . Positive_regulation TNF NFKB1 9277450 450776 Moreover , the inhibitors *blocked* SP-A dependent increases in [tumor necrosis factor-alpha] mRNA levels . Positive_regulation TNF NFKB1 9299419 453453 Hence , it was of interest to investigate the role of endogenous glutathione status in [TNF alpha] *induced* activation in skeletal muscle derived cells . Positive_regulation TNF NFKB1 9299419 453455 Results from GSSG reductase inhibited cells suggest that GSSG may participate in , but is not required for , [TNF alpha] *induced* activation . Positive_regulation TNF NFKB1 9325328 456917 Lipid peroxidation is involved in the *activation* of by [tumor necrosis factor] but not interleukin-1 in the human endothelial cell line ECV304 . Positive_regulation TNF NFKB1 9332715 457646 The oxidative stress responsive transcription factor consists of a p50 ( 50 kDa ) and p65/RelA ( 65 kDa ) component and can be *activated* in vitro by [TNF alpha] , IL1 beta , hydrogen peroxide and oxygen radicals . Positive_regulation TNF NFKB1 9343439 459030 However , since *activation* of by [TNF-alpha] is often transient and would not activate long-term kappaB dependent transcription effectively , we explored the effects of IFN-gamma on TNF-alpha induced NF-kappaB activity . Positive_regulation TNF NFKB1 9346915 459565 In this cell line ( EL4D6/76 ) , [tumor necrosis factor] *induced* ligand/receptor internalization , nuclear translocation , IL-2 production , and the activation of neutral (N)-SMase and acid ( A ) -SMase . Positive_regulation TNF NFKB1 9366558 466089 Transcriptional control of the [TNF alpha] gene is *regulated* by the . Positive_regulation TNF NFKB1 9374527 465136 Despite *activation* of by [TNF] , this transcription factor was not required for TNF induced transcription of gamma-GCS-HS as revealed by deletion constructs of the gamma-GCS-HS promoter subcloned in a chloramphenicol acetyltransferase reporter vector and transfected into HepG2 cells . Positive_regulation TNF NFKB1 9383399 345237 Our data show that one ROI species , H2O2 acts as a messenger in the [TNF-] and okadaic acid induced post-translational *activation* of . Positive_regulation TNF NFKB1 9388244 466789 *Activation* of by [TNF-alpha] occurred within 15 min and coincided with rapid degradation of IkappaBalpha . Positive_regulation TNF NFKB1 9417872 472284 Expression of bcl-2 did not impose a block to , or potentiate , [TNF-alpha] signaling of I kappa B alpha degradation , nuclear import of the RelA p65 , or *transactivation* . Positive_regulation TNF NFKB1 9418855 480454 *Activation* of by [TNF] and IL-1 is initiated by the phosphorylation of the inhibitory subunit , IkappaB , which targets IkappaB for degradation and leads to the release of active NF-kappaB . Positive_regulation TNF NFKB1 9439980 475070 IL1 alpha and [TNF-alpha] rapidly *induced* both AP-1 and DNA binding activities in +/+ ( - ) 1.LDA11 stromal cells . Positive_regulation TNF NFKB1 9454839 484402 Furthermore , unlike TNF-alpha treatment , NGF treatment did not significantly activate JNK , although both [TNF-alpha] and NGF *induced* nuclear translocation of . Positive_regulation TNF NFKB1 9486215 488322 In the present study , electrophoretic mobility shift assays ( EM-SAs ) and pyrrolidine dithiocarbamate ( PDTC ) , an inhibitor of NF-kappa B activation , were utilized to determine the *role* of activation in TPA and [TNF-alpha] inhibition of the surfactant proteins in NCI-H441 cells . Positive_regulation TNF NFKB1 9565556 500910 Interestingly , both the potent physiological inducer of NF-kappaB [TNFalpha] as well as endoplasmic reticulum overload can *induce* via a PDTC sensitive pathway . Positive_regulation TNF NFKB1 9636658 513389 The role of DNA-PK , a protein kinase involved in the response to DNA damage , in the *activation* of by IR and [TNF alpha] was examined . Positive_regulation TNF NFKB1 9636658 513417 These results indicate that DNA-PK participates in the *activation* of by IR but not by [TNF alpha] . Positive_regulation TNF NFKB1 9642107 514179 At 150 microM LA-Plus , but not LA , inhibited [TNFalpha] *induced* activation . Positive_regulation TNF NFKB1 9683180 521411 Moreover , these findings support the hypothesis that Kupffer cells play a pivotal role in peroxisome proliferator induced hepatocyte proliferation through rapid activation and subsequent *induction* of [TNF alpha] production . Positive_regulation TNF NFKB1 9691914 523156 [TNF-alpha] induction of ICAM-1 expression is *mediated* by the transcription factor and can be inhibited by blocking I kappa B alpha degradation . Positive_regulation TNF NFKB1 9718198 528180 These results suggest that the rapid *activation* of by [TNF-alpha] is mainly due to the nuclear translocation of NF-kappaB pre existing in cytosol , and that the subsequent increase in the expression of p50 and p65 may result in the persistent activation of NF-kappaB during TNF-alpha stimulation . Positive_regulation TNF NFKB1 9718198 528199 These results suggest that the *activation* of by [TNF-alpha] may play an important role in the production of cytokines and cell adhesion molecules from osteoblasts , leading to the promotion of bone resorption and inflammation . Positive_regulation TNF NFKB1 9724317 529416 In saline pretreated rats , LPS caused a rapid decrease in myocardial IkappaB-alpha protein levels , *activation* of , and increased [TNF-alpha] production . Positive_regulation TNF NFKB1 9728048 530025 These findings indicate that [TNF-alpha] *induces* activation and the resultant E-selectin gene expression by a pathway that involves formation of ROS and that E-selectin expression can be inhibited by the antioxidant action of NAC or PDTC . Positive_regulation TNF NFKB1 9794408 542962 Fc epsilonRI mediated *induction* of [TNF-alpha] gene expression in the RBL-2H3 mast cell line : regulation by a novel nuclear binding complex . Positive_regulation TNF NFKB1 9802878 544026 In the present study , which uses mice with genetic deletions of the proteins of NF-kappaB complex , we provide data demonstrating that increased expression of the p50 subunit of directly *results* in the downregulation of LPS induced [TNF] production . Positive_regulation TNF NFKB1 9830008 551247 H2O2 and [tumor necrosis factor-alpha] *induce* differential binding of the redox-responsive transcription factors AP-1 and to the interleukin-8 promoter in endothelial and epithelial cells . Positive_regulation TNF NFKB1 9830008 551280 [TNFalpha] *induced* complexes containing Rel A ( p65 ) . Positive_regulation TNF NFKB1 9916895 559055 We determined that binding sites for both ( -186 bp region ) and C/EBP ( -198 bp region ) are *involved* in [TNF-alpha] and IL-1beta mediated ICAM-1 upregulation . Positive_regulation TNF NFKB1 9990294 597305 Using antisense oligonucleotides , we confirmed that the [TNF-alpha-stimulation] of HA synthesis by MRC-5 cells is *dependent* on the activation of the . Positive_regulation TNF NFKBIA 10201924 605676 In contrast , [TNF-alpha] *induced* degradation of in the neuronal cells , suggesting that failure to induce I kappa B alpha degradation is likely due to a defect in virus mediated signaling rather than to a defect involving neuronal I kappa B alpha . Positive_regulation TNF NFKBIA 10619864 657394 Finally , S. typhimurium , but not [TNF-alpha] , *induced* a Ca ( 2+ ) -dependent phosphorylation of . Positive_regulation TNF NFKBIA 10671572 667270 [Tumor necrosis factor-alpha (TNF-alpha)] *induced* normal phosphorylation of but failed to induce degradation of phosphorylated IkappaBalpha . Positive_regulation TNF NFKBIA 10869349 730086 [Tumor necrosis factor (TNF)] and interleukin-1 *induce* phosphorylation , leading to I kappa B-alpha degradation and translocation of NF-kappa B to the nucleus where it activates genes important in inflammatory and immune responses . Positive_regulation TNF NFKBIA 10947072 721893 Lipopolysaccharide triggered desensitization of [TNF-alpha] mRNA expression *involves* lack of phosphorylation of in a murine macrophage-like cell line , P388D1 . Positive_regulation TNF NFKBIA 11698503 878181 In naive cells , LPS , [TNF-alpha] , and IL-1beta *induced* degradation , kinase phosphorylation , and NF-kappaB DNA binding . Positive_regulation TNF NFKBIA 12060665 975683 [TNF] *induced* phosphorylation and degradation in MO7E cells but not in MBA cells . Positive_regulation TNF NFKBIA 12174385 974528 sCCK-8 *inhibits* LPS induced [TNF-alpha] mRNA expression by regulating NF-kappaB activity in rat PIMs , which is mediated through CCK receptors and inhibiting degradation . Positive_regulation TNF NFKBIA 12867425 1141842 A role for NF-kappaB essential modifier/IkappaB kinase-gamma ( NEMO/IKKgamma ) ubiquitination in the *activation* of the by [tumor necrosis factor-alpha] . Positive_regulation TNF NFKBIA 15390118 1304805 [TNF] *induced* a time dependent degradation of in microglial cells that was reverted by two inhibitors of nuclear factor kappaB activation , N-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) and N-CBZ-Leu-Leu-Leu-al ( MG132 ) . Positive_regulation TNF NFKBIA 16303143 1546888 Further , [TNF-alpha] stimulation *induced* the degradation of and resulted in the transcriptional activation of NF-kappaB . Positive_regulation TNF NFKBIA 17018860 1682934 In the resting cell , RhoA suppresses Cdc42 activation , degradation , nuclear factor-kappaB (NF-kappaB) activation , and *induction* of [TNFalpha] and NF-kappaB dependent chemokines . Positive_regulation TNF NFKBIA 17961489 1844746 In this pathway , [TNFalpha] *induces* the phosphorylation , ubiquitination , and proteasomal degradation of , which leads to the release and translocation of the NFkappaB transcriptional complex into the nucleus . Positive_regulation TNF NFKBIA 18513711 1928404 Further studies revealed that compounds 2 , 18 , and 19 *inhibited* LPS induced NO and [TNF-alpha] production in microglia by blocking phosphorylation and degradation . Positive_regulation TNF NFKBIA 19647754 2182946 By acting downstream of NF-kappaB to inhibit I kappaB alpha gene induction by TNF-alpha , PACAP may block *dependent* negative autoregulation of [TNF-alpha] signaling through NF-kappaB , prolonging TNF-alpha dependent signaling to neuropeptide encoding genes in chromaffin cells . Positive_regulation TNF NFKBIA 20663042 2298140 These results indicated that the downregulation of [TNF-alpha] by S. tenuifolia water extract may have *involved* the inhibition of both degradation and activation of c-Jun and ATF-2 involving suppression of JNK/SAPK . Positive_regulation TNF NFKBIA 9691914 523157 [TNF-alpha] induction of ICAM-1 expression is mediated by the transcription factor NF-kappa B and can be *inhibited* by blocking degradation . Positive_regulation TNF NFKBIA 9743602 532609 In contrast , [TNF-alpha] rapidly *induced* degradation within 5 min and IkappaBbeta degradation within 15 min. Cycloheximide did not prevent LPS induced IkappaBalpha degradation , indicating that newly synthesized proteins induced by LPS were not involved in LPS stimulated IkappaBalpha degradation . Positive_regulation TNF NFKBIA 9792645 542597 [Tumor necrosis factor-alpha] activation of nuclear transcription factor-kappaB in marrow macrophages is *mediated* by c-Src tyrosine phosphorylation of . Positive_regulation TNF NFKBIA 9792645 542606 Within the same time frame , [TNF] *induced* c-Src associates with in a long lived complex . Positive_regulation TNF NFKBID 15749903 1379781 Furthermore , small interference RNA mediated reduction in expression in RAW264.7 cells *resulted* in increased LPS induced production of IL-6 , but not [TNF-alpha] . Positive_regulation TNF NFKBIZ 12565889 1054340 , a new negative-regulator of nuclear factor-kappa B (NF-kappa B) , is strongly *induced* by lipopolysaccharide or interleukin-1 beta stimulation , but not by [tumor necrosis factor-alpha] . Positive_regulation TNF NFKBIZ 20220144 2249433 As IL-17 stimulation stabilizes the IkappaB-zeta transcript , we propose a model where [TNF-alpha] induces activation and binding of NF-kappaB to the promoters of both NFKBIZ and LCN2 genes but *induce* only transcription of . Positive_regulation TNF NGF 11404390 825441 *regulates* [TNF-alpha] production in mouse macrophages via MAP kinase activation . Positive_regulation TNF NGF 11404390 825443 The *induction* of [TNF-alpha] production by was blocked by K252a , an inhibitor of the TrkA receptor . Positive_regulation TNF NGF 16586095 1574802 In contrast , [TNF-alpha] *induced* rapid and substantial increases in expression of the genes encoding IL-6 , MCP-1 , and TNF-alpha itself ; Positive_regulation TNF NGF 16956589 1627646 In addition , we observe that not only exogenous TNF-alpha but also [TNF-alpha] produced by astrocytes *induce* and GDNF production in astrocytes . Positive_regulation TNF NGF 17947706 1814420 could markedly *promote* LPS induced expression of HLA-DR , CD40 , CD80 , CD83 , CD86 , CCR7 , secretion of IL-12p40 and proinflammatory cytokines IL-1 , IL-6 , [TNF-alpha] , and the T cell stimulating capacity of MoDCs , indicating that NGF can promote LPS induced DC maturation . Positive_regulation TNF NGF 18094051 1869015 We find that can *induce* [TNF-alpha] synthesis through the nuclear factor-kappaB transcription factor . Positive_regulation TNF NGF 18094051 1869024 Thus , NGF and *induced* [TNF-alpha] cooperate to activate Akt , promoting survival of normal neural cells . Positive_regulation TNF NGF 18094051 1869025 However , the *induced* [TNF-alpha] suppresses Erk activation by NGF , blocking NGF induced differentiation of neuroblastoma cells . Positive_regulation TNF NGF 20133718 2213536 Consistent with this , we show that *induced* robust expression of [tumor necrosis factor alpha (TNFalpha)] in Müller cells and that genetic or biochemical ablation of TNFalpha blocked proNGF induced death of retinal neurons . Positive_regulation TNF NGF 20133718 2213538 Mice rendered null for p75 ( NTR ) , its coreceptor sortilin , or the adaptor protein NRAGE were defective in *induced* glial [TNFalpha] production and did not undergo proNGF induced retinal ganglion cell death . Positive_regulation TNF NGF 21229279 2419647 Plasma levels of [tumor necrosis factor-a (TNF-a)] , interleukin 8 (IL-8) , interferon-? inducible protein-10 (IP-10) , monocyte chemotactic protein-1 (MCP-1) , soluble urokinase-type plasminogen activator ( suPAR ) , monokine *induced* by ?-interferon ( MIG ) , human hepatocyte growth factor (HGF) , insulin , interleukin 6 (IL-6) , interleukin 1-ß (IL-1ß) , leptin , and were analyzed . Positive_regulation TNF NGF 22351621 2624261 We investigated the effects of low-level laser on the accumulation of HIF-1a , [tumor necrosis factor-a (TNF-a)] , and interleukin-1ß (IL-1ß) in controlling neuropathic pain , as well as on the *activation* of vascular endothelial growth factor ( VEGF ) and in promoting functional recovery in a rat CCI model . Positive_regulation TNF NGF 23365678 2739031 While *induced* [TNF-a] expression in vivo , it selectively activated RhoA in primary RGC cultures and RGC-5 cell line . Positive_regulation TNF NGF 9833249 552020 Out data showed that IL-1 beta , but not [TNF-alpha] , *induces* an increase in levels , while concomitant injection of both cytokines enhances the effect of IL-1 beta on NGF presence . Positive_regulation TNF NID1 18434122 1926368 IL-1beta or [TNF-alpha] alone *induced* increased secretion of type IV collagen , laminin-1 , and , all of which contributed to this upregulation . Positive_regulation TNF NKAP 14550261 1152595 Moreover , down-regulation of by antisense RNA significantly *inhibited* [TNF-] and IL-1 induced NF-kappaB activation . Positive_regulation TNF NLRC4 22749731 2627246 *stimulated* the [TNF-a] and IL-1ß production , upregulated the CD86 and MHC II expression , and enhanced the phagocytic activity of macrophages . Positive_regulation TNF NLRP3 20682587 2457601 Stimulation of with E. coli RNA *led* to the highest induction of [TNF-a] , IL-6 , IL-12p40 , RANTES and IFN-ß , whereas TLR7 , TLR3 , TLR9 , NOD1 and NOD2 agonists had lower effects . Positive_regulation TNF NLRP3 22065079 2540528 HMGB1 and induce proinflammatory responses and *lead* to interleukin-1ß and [TNF-a] secretion and NF-?B activity , thereby promoting cell survival and tumor growth . Positive_regulation TNF NLRP3 22711073 2621316 *Role* of and CARD8 in the regulation of [TNF-a] induced IL-1ß release in vascular smooth muscle cells . Positive_regulation TNF NM 15615881 1357496 Dentin sialoprotein (DSP) and dentin phosphoprotein (DPP) , the major dentin proteins , have been shown to *induce* through release of IL-1beta , [TNF-alpha] , MIP-2 , and KC . Positive_regulation TNF NM 21968692 2507447 IL-33 may play a role in AS development via enhancing [TNF-a] production by PBMCs and *inducing* . Positive_regulation TNF NM 8323453 223240 On the other hand , [TNF alpha] *induced* neither nor enhancement of PAF induced neutrophil migration . Positive_regulation TNF NM 9306414 454327 and exogenous recombinant [TNF alpha] , IL-1 , IL-6 and CINC *induced* into rat pleural cavity . Positive_regulation TNF NOD1 16418393 1514585 stimulation did not *induce* [TNFalpha] , interleukin 12 , and interferon gamma , suggesting that the primary role of Nod1 is to induce the recruitment of immune cells . Positive_regulation TNF NOD1 23055923 2685187 The interaction of Salmonella pathogen associated molecular patterns ( PAMPs ) with Toll-like receptors ( TLRs ) and *leads* to inflammasome formation , activation , and recruitment of neutrophils and macrophages and the production of pro-inflammatory cytokines , most notably interleukin (IL)-6 , IL-1ß , [tumor necrosis factor (TNF)-a] , and interferon-gamma (IFN)-? . Positive_regulation TNF NOD1 24382222 2883545 Oleate/palmitate mixture activated the NF-?B pathway and *induced* interleukin-6 , [tumor necrosis factor-a] , and monocyte chemoattractant protein-1 mRNA expressions in adipocytes from mice deficient in Toll-like receptor 4 , and these effects were blocked by siRNA targeting . Positive_regulation TNF NOD2 12671897 1076280 [TNF-alpha] *induced* an up-regulation of in epithelial cell lines ( HT-29 , SW620 , SW948 , HeLa S3 ) and in primary colonic epithelial cells . Positive_regulation TNF NOD2 15800781 1417376 We sought to determine whether mediated NF-kappaB activation can *contribute* to MDP induced [TNFalpha] production and , consequently , if polymorphisms in both genes affect the control of such induction . Positive_regulation TNF NOD2 15800781 1417383 Transfection and electrophoretic mobility shift assays ( EMSA ) experiments in HEK293 cells demonstrated that MDP exposure stimulates [TNFalpha] gene transcription , as a *result* of induced NF-kappaB activation and binding to TNFalpha promoter . Positive_regulation TNF NOD2 17709422 1806079 Mycolylarabinogalactan peptidoglycan ( PGN ) , the cell wall core of M. tuberculosis , stimulated macrophages to release [tumor necrosis factor (TNF)] and interleukin-12p40 in a partially NOD2 dependent manner , and M. tuberculosis PGN *required* for the optimal induction of TNF . Positive_regulation TNF NOD2 18773284 2028347 Combined TLR2 and stimulation *induced* a four-fold higher secretion of [TNFalpha] and a 13-fold higher secretion of IL-1 beta in patients . Positive_regulation TNF NOD2 20016198 2247955 Apically added LGG , TLR2 and ligands , but not Bb , *enhanced* IFN-gamma , IL-12 and/or [TNF-alpha] secretion . Positive_regulation TNF NOD2 21209364 2402360 Finally , using mononuclear phagocytes from NOD2 knockout mice , we observed that [TNF] production in response to HKSA was *dependent* on for monocytes and peritoneal macrophages . Positive_regulation TNF NOD2 23055923 2685188 The interaction of Salmonella pathogen associated molecular patterns ( PAMPs ) with Toll-like receptors ( TLRs ) and *leads* to inflammasome formation , activation , and recruitment of neutrophils and macrophages and the production of pro-inflammatory cytokines , most notably interleukin (IL)-6 , IL-1ß , [tumor necrosis factor (TNF)-a] , and interferon-gamma (IFN)-? . Positive_regulation TNF NOD2 23396949 2748370 However , loss of in IL-10-deficient macrophages *reduced* IL-6 , [TNF-a] , and IL-12p40 production in response to bacterial stimulation . Positive_regulation TNF NOD2 23437331 2744581 Here , we show that p62 positively regulates *induced* NF-?B activation and p38 MAPK , and subsequent production of cytokines IL-1ß and [TNF-a] . Positive_regulation TNF NOD2 23868940 2825263 induced cyclooxygenase-2 expression in macrophages was dependent on p38 mitogen activated protein kinase activation and was *mediated* by interleukin-1ß and [tumor necrosis factor-a] . Positive_regulation TNF NOD2 24611904 2933910 Based on recent evidence that XIAP is essential for nucleotide binding and oligomerization domains ( NOD)1/2 signalling , we evaluated the use of a simple flow cytometric assay assessing [tumour necrosis factor (TNF)] production of monocytes in *response* to stimulation by muramyl dipeptides ( L18-MDP ) for the functional diagnosis of XIAP deficiency . Positive_regulation TNF NOS1 11085984 786348 *Activation* of the endothelial by [tumor necrosis factor-alpha] . Positive_regulation TNF NOS1 11224628 787961 In contrast , expression is *induced* by IL-1 , [tumor necrosis factor] , and gamma interferon , a T-helper 1 cytokine profile . Positive_regulation TNF NOS1 11399519 824222 Interferon (IFN)-gamma and Herpes simplex [virus/tumor necrosis factor-alpha] synergistically *induce* 2 in macrophages through cooperative action of nuclear factor-kappa B and IFN regulatory factor-1 . Positive_regulation TNF NOS1 11414678 828987 The ability of Japanese encephalitis virus ( JEV ) and JEV induced macrophage derived factor ( MDF ) to modulate nitric oxide synthase (NOS) activity in brain and [tumor necrosis factor-alpha (TNF-alpha)] and the possible antiviral *role* of during JEV infection were investigated . Positive_regulation TNF NOS1 11930230 894634 The activity *increased* in the [TNF-alpha] and the TNF alpha+CCK-8 groups , while no significant difference was observed between the vehicle and the CCK-8 groups . Positive_regulation TNF NOS1 11943165 928667 Recombinant glucocorticoid induced [tumor necrosis factor] receptor ( rGITR ) *induces* in murine macrophage . Positive_regulation TNF NOS1 12506117 1056906 Endothelial *enhances* lipopolysaccharide stimulated [tumor necrosis factor-alpha] expression via cAMP mediated p38 MAPK pathway in cardiomyocytes . Positive_regulation TNF NOS1 12720581 1084112 In a macrophage cell line ( RAW 264.7 ) activated with interferon gamma plus lipopolysaccharide , both isoflavones were found to *inhibit* NO production and [tumour necrosis factor alpha (TNF-alpha)] secretion dose-dependently , but they did not affect mRNA levels for inducible and cyclo-oxygenase-2 . Positive_regulation TNF NOS1 12972406 1185616 Inhibition of activity also *suppressed* production of [TNF-alpha] and macrophage inflammatory protein-2 by LPS stimulated mouse alveolar MH-S macrophages , and this was restored by NO . Positive_regulation TNF NOS1 15501965 1327221 We investigated the *role* of endothelial in determining the tumor-selective activity of [TNF] . Positive_regulation TNF NOS1 16421203 1554180 Functional link between [TNF] biosynthesis and CaM dependent *activation* of inducible in RAW 264.7 macrophages . Positive_regulation TNF NOS1 16770320 1590742 AM404 completely prevented the overproduction of NO and the overexpression of , *inhibited* the increase in [tumour necrosis factor alpha (TNFalpha)] and enhanced the production of interleukin-10 . Positive_regulation TNF NOS1 17466955 1761297 *Role* of neuronal in lipopolysaccharide induced [tumor necrosis factor-alpha] expression in neonatal mouse cardiomyocytes . Positive_regulation TNF NOS1 17466955 1761304 However , the *role* of in LPS induced [TNF-alpha] expression is not known . Positive_regulation TNF NOS1 20504765 2289237 Moreover , [tumor necrosis factor] alpha induced nuclear translocation of CLIC4 is *dependent* on activity . Positive_regulation TNF NOS1 24194350 2868554 Further , candesartan in combination with tPA increased activity of MMP-9 but decreased MMP-3 , nuclear factor kappa-B and [tumor necrosis factor-a] expression and enhanced *activation* of endothelial . Positive_regulation TNF NOS1 24905701 2952072 Furthermore , HMGB1 and IL-1ß and/or [tumor necrosis factor] a ( but not HMGI/Y ) also significantly *induced* inducible , NO , and interleukin (IL)-8 production in human cartilage and chondrocytes . Positive_regulation TNF NOS1 7543491 314292 IFN-gamma and [TNF-alpha] , potent inhibitors of hematopoiesis , *induce* in various cell types . Positive_regulation TNF NOS1 8737749 376962 Here we show that in cultured bovine chondrocytes and explants of human osteoarthritic cartilage both and cyclooxygenase activities were *induced* by the inflammatory mediators , lipopolysaccharide , and interleukin-1 beta or [tumor necrosis factor-alpha] . Positive_regulation TNF NOS1 9133471 427248 IL-1 , [tumor necrosis factor-alpha] , and inducible *increased* slowly until day 7 , declining thereafter . Positive_regulation TNF NOS2 10728381 678156 [TNF alpha] *induced* a concentration dependent increase in mRNA expression and nitrite production as well as significant apoptosis of cardiomyocytes in the wild type mice ( n = 4 , P < 0.01 ) . Positive_regulation TNF NOS2 10807663 692263 However , [TNF-alpha] alone did not *induce* promoter activity , protein expression , or nitrite production , indicating that NF-kappaB activation alone is not sufficient for iNOS induction . Positive_regulation TNF NOS2 10839591 698186 In the relationship between cardiomyopathy and encephalopathy , the *activation* of by [TNF-alpha] may have a significant pathogenetic role in HIV disease . Positive_regulation TNF NOS2 11002413 767497 [TNF-alpha] alone neither *induced* in USAC cells nor caused production of NO , but addition of TNF-alpha to USAC cells pretreated with LPS and IFN-gamma enhanced the expression of iNOS mRNA , induced iNOS protein and produced NO . Positive_regulation TNF NOS2 11003590 734695 Moreover , Western blot analysis clearly showed that [TNF-alpha] alone *induces* the expression of after 12-24 h treatment of differentiated 3T3F442A cells . Positive_regulation TNF NOS2 11085984 786349 *Activation* of the endothelial by [tumor necrosis factor-alpha] . Positive_regulation TNF NOS2 11095498 755263 [Tumor necrosis factor-alpha] and nerve growth factor synergistically *induce* in pheochromocytoma cells . Positive_regulation TNF NOS2 11095498 755267 has been reported in tangle bearing neurons of patients with Alzheimer 's disease ( AD ) , and can be *induced* by [tumor necrosis factor-alpha (TNFalpha)] . Positive_regulation TNF NOS2 11181643 785299 In addition to their other functions , [TNF-alpha] and IFN-gamma both *induce* the ( iNOS ) . Positive_regulation TNF NOS2 11192310 779553 This study suggests that HL-1 myocyte can not be *induced* by [TNF-alpha] , unlike macrophage iNOS . Positive_regulation TNF NOS2 11224628 787962 In contrast , expression is *induced* by IL-1 , [tumor necrosis factor] , and gamma interferon , a T-helper 1 cytokine profile . Positive_regulation TNF NOS2 11399519 824223 Interferon (IFN)-gamma and Herpes simplex [virus/tumor necrosis factor-alpha] synergistically *induce* 2 in macrophages through cooperative action of nuclear factor-kappa B and IFN regulatory factor-1 . Positive_regulation TNF NOS2 11453704 837103 Furthermore , co-incubating S. typhimurium with Mphi resulted in interleukin (IL)-12p40 , IL-6 and [tumor necrosis factor-alpha] production as well as *induction* while IL-12p70 was not detectable . Positive_regulation TNF NOS2 11474215 841760 Also , [TNF-alpha] *induced* gene expression in anterior pituitary cells as assessed by reverse transcriptase-polymerase chain reaction . Positive_regulation TNF NOS2 11474215 841762 The current results indicate that NO is involved in the inhibitory effect of TNF-alpha on prolactin secretion and that [TNF-alpha] *induces* transcription and stimulates NO synthesis in anterior pituitary cells . Positive_regulation TNF NOS2 11521163 852420 However , incubation with HCL-31D ( 1 approximately 50 microM ) for 24 h caused significant attenuation of nitrite and [TNF-alpha] formation as well as mRNA *induction* in a dose dependent manner but no effect on iNOS activity in RASMC . Positive_regulation TNF NOS2 11521163 852423 We proposed that the elevation of cAMP levels by HCL-31D may be involved in the prevention of [TNF-alpha] formation and *induction* . Positive_regulation TNF NOS2 11730360 884943 We found that both IL-1beta and [TNF-alpha] could independently activate cytosolic NF-kappaB , direct its translocation into the nucleus , and *induce* monomer synthesis . Positive_regulation TNF NOS2 11976279 934396 Western blot analysis and immunohistochemistry revealed that [tumour necrosis factor alpha (TNFalpha)] plus interferon-gamma (IFNgamma) synergistically *induce* gene expression in the endothelium but not in the smooth muscle of these segments while constitutive endothelial NO synthase (eNOS) abundance was markedly reduced . Positive_regulation TNF NOS2 12120758 964996 The present study was to investigate the effect of a calcium antagonist amlodipine on nitrite , [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) formation and *induction* both in lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) treated rat aortic smooth muscle cells ( RASMC ) and in a rat model of endotoxemia . Positive_regulation TNF NOS2 12153521 971456 Both LPS and [TNF] *induce* the expression of the NF-kappaB dependent gene , which occurs subsequent to NF-kappaB activation . Positive_regulation TNF NOS2 12384474 998791 In cultured adult rat CFbs , IL-1beta ( 5 ng/ml ) , but not interferon-gamma ( 10 ng/ml ) or [tumor necrosis factor-alpha] ( 10 ng/ml ) , *induced* expression and NO production that was associated with an increase in caspase-3 activity and apoptotic cell death . Positive_regulation TNF NOS2 12506117 1056907 Endothelial *enhances* lipopolysaccharide stimulated [tumor necrosis factor-alpha] expression via cAMP mediated p38 MAPK pathway in cardiomyocytes . Positive_regulation TNF NOS2 12594738 1060939 Although [TNFalpha] alone *induced* neither mRNA expression nor nitrite formation , it significantly potentiated the effect of LPS on both . Positive_regulation TNF NOS2 12720581 1084113 In a macrophage cell line ( RAW 264.7 ) activated with interferon gamma plus lipopolysaccharide , both isoflavones were found to *inhibit* NO production and [tumour necrosis factor alpha (TNF-alpha)] secretion dose-dependently , but they did not affect mRNA levels for inducible and cyclo-oxygenase-2 . Positive_regulation TNF NOS2 12754112 1090434 Investigation of downstream signaling pathways of apoptosis revealed that [TNF-alpha] *induced* the expression of , but failed to stimulate the activity of caspase 3 . Positive_regulation TNF NOS2 12757853 1090892 We conclude that colloidal-iron phagocytosed by liver Kupffer cells enhanced LPS induced NO production in vivo , *induction* in the liver , and release of IL-6 , IL-1beta , and [TNF-alpha] . Positive_regulation TNF NOS2 14996411 1216224 The present investigation demonstrated that oligochitosan can significantly increase the activity of and *induce* the synthesis of nitric oxide ( NO ) and [tumor necrosis factor-alpha (TNF-alpha)] in macrophages . Positive_regulation TNF NOS2 15501965 1327222 We investigated the *role* of endothelial in determining the tumor-selective activity of [TNF] . Positive_regulation TNF NOS2 16133968 1450285 [TNF-alpha] , including other proinflammatory cytokines alone or in combination , *induces* expression and upregulates inflammatory responses . Positive_regulation TNF NOS2 16144552 1461263 We previously showed in NGF-responsive PC12 cells that [tumor necrosis factor alpha (TNFalpha)] and NGF synergistically *induce* the expression of the free-radical producing enzyme . Positive_regulation TNF NOS2 16154786 1631104 A higher level of NO was produced when CCLs were exposed to the *inducing* cocktail [TNF/IL-1/LPS] , and NO synthesis could be inhibited by both l-NMMA , a general nitric oxide synthase (NOS) inhibitor and l-NIL , a specific iNOS inhibitor . Positive_regulation TNF NOS2 16421203 1554181 Functional link between [TNF] biosynthesis and CaM dependent *activation* of inducible in RAW 264.7 macrophages . Positive_regulation TNF NOS2 16857446 1588733 This contamination coincided with an *increase* in [TNF-alpha] and with a greater expression of . Positive_regulation TNF NOS2 17466955 1761298 *Role* of neuronal in lipopolysaccharide induced [tumor necrosis factor-alpha] expression in neonatal mouse cardiomyocytes . Positive_regulation TNF NOS2 17851925 1910974 The fluorescent immunohistochemistory study demonstrated that LPS and [TNF-alpha] *induced* the expression of in HNMECs . Positive_regulation TNF NOS2 18242889 1864994 However , aminoguanidine ( AG ) , a selective inhibitor of , and pentoxifylline (PTX) , an *inhibitor* of [tumor necrosis factor alpha (TNF-alpha)] synthesis , had no effect on LPS induced upregulation of HO-1 in fetal liver . Positive_regulation TNF NOS2 18369347 1912829 The results showed that [TNF-alpha] *induced* expression and release of NO after 24-h treatment of differentiated 3T3-L1 adipocytes . Positive_regulation TNF NOS2 18755151 1975277 IFNgamma and [TNF] dramatically *induced* the expression of by BMSCs in culture , and BMSCs generated from iNOS knockout mice did not induce apoptosis of lymphoma cells in the presence of IFNgamma and TNF . Positive_regulation TNF NOS2 18957328 2014825 Interleukin-1beta (IL-1beta) and [tumor necrosis factor-alpha (TNF-alpha)] *induced* gene expression and NO production , although these actions were inhibited by L-NG-monomethylarginine ( L-NMMA ) and decreased alkaline phosphatase ( ALPase ) activity . Positive_regulation TNF NOS2 19188055 2049372 Western blot analysis of mouse macrophage cell line RAW 264.7 activated with lipopolysaccharide showed that bisdemethoxycurcumin inhibited inducible nitric oxide synthase (iNOS) production significantly but had no effect on tumor necrosis factor-alpha (TNF-alpha) production , whereas curcumin showed stronger suppression of protein production and *inhibited* [TNF-alpha] protein production significantly . Positive_regulation TNF NOS2 19604438 2105676 [TNF-alpha] *increases* expression of in macrophages and vascular endothelial cells . Positive_regulation TNF NOS2 19724692 2133960 However , trichomonad induced NF-kappaB activation and [TNF-alpha] production in macrophages were significantly *inhibited* by inhibition of levels with L-NMMA ( NO synthase inhibitor ) . Positive_regulation TNF NOS2 20504765 2289238 Moreover , [tumor necrosis factor] alpha induced nuclear translocation of CLIC4 is *dependent* on activity . Positive_regulation TNF NOS2 20678226 2305645 This activation of IDO by direct application of LPS was preceded by synthesis and secretion of [TNFalpha] and IL-6 protein and *activation* of while IFN gamma expression was undetectable . Positive_regulation TNF NOS2 21567079 2441236 Newcastle disease virus ( NDV ) is an interesting agent for activating innate immune activity in macrophages including secretion of [TNF-a] and IFN-a , upregulation of TRAIL and *activation* of NF-?B and . Positive_regulation TNF NOS2 21637955 2532006 In cultured HMC , [TNF-a] *induces* the expression of , which is attenuated by knockdown AR with siRNA . Positive_regulation TNF NOS2 21950195 2488076 endothelial ( eNOS ) , neuronal ( nNOS ) , and *inducible* ( ) nitric oxide synthases , nitrotyrosine and [tumour necrosis factor alpha (TNF-alpha)] in ng/mg-protein were determined . Positive_regulation TNF NOS2 22005300 2503241 Surprisingly , MDL-1 induced NO and [TNF-a] production *required* eNOS but not . Positive_regulation TNF NOS2 22083995 2508688 In particular , diosgenin was able to *inhibit* [TNF-a] and IL-6 , but both compounds did not affect LPS induced expression . Positive_regulation TNF NOS2 23280586 2853697 Furthermore , HC volatile oil *inhibited* the production of NO and [TNF-a] by down regulating LPS stimulated and TNF-a mRNA expression . Positive_regulation TNF NOS2 24194350 2868555 Further , candesartan in combination with tPA increased activity of MMP-9 but decreased MMP-3 , nuclear factor kappa-B and [tumor necrosis factor-a] expression and enhanced *activation* of endothelial . Positive_regulation TNF NOS2 24777714 2950242 Furthermore , expressions of tumor necrosis factor (TNF)-a and monocyte chemoattractant protein (MCP)-1 messenger ( m ) RNA in U87 and C6 cells were detected by an RT-PCR , and [TNF-a] and MCP-1 *induced* protein expression in time- and concentration dependent manners . Positive_regulation TNF NOS2 24905701 2952073 Furthermore , HMGB1 and IL-1ß and/or [tumor necrosis factor] a ( but not HMGI/Y ) also significantly *induced* inducible , NO , and interleukin (IL)-8 production in human cartilage and chondrocytes . Positive_regulation TNF NOS2 7504484 237426 Here we show that interferon-gamma (IFN-gamma) and [tumor necrosis factor-alpha (TNF-alpha)] synergistically *induced* NO production and mRNA expression in mouse islet cells . Positive_regulation TNF NOS2 7514535 254045 However , synthesis *requires* the presence of both [TNF] and IFN-gamma , while VCAM-1 can be induced by either cytokine alone . Positive_regulation TNF NOS2 7530759 291721 Although [TNF+LPS] *induce* expression and inhibit insulin secretion by intact islets , this combination does not induce the expression of iNOS by beta or alpha cells purified by fluorescence activated cell sorting ( Facs ) . Positive_regulation TNF NOS2 7530759 291731 Immunohistochemical localization of iNOS and insulin confirm that [TNF+LPS] *induce* the expression of by islet beta cells , and that a small percentage of noninsulin containing cells also express iNOS . Positive_regulation TNF NOS2 8737749 376963 Here we show that in cultured bovine chondrocytes and explants of human osteoarthritic cartilage both and cyclooxygenase activities were *induced* by the inflammatory mediators , lipopolysaccharide , and interleukin-1 beta or [tumor necrosis factor-alpha] . Positive_regulation TNF NOS2 9133471 427249 IL-1 , [tumor necrosis factor-alpha] , and inducible *increased* slowly until day 7 , declining thereafter . Positive_regulation TNF NOS2 9193655 438002 Although the precise mechanism requires further investigation , our results indicate that ADP-ribosylation is a crucial step restricted to the signalling pathway which leads to mRNA induction , as well as [TNF] and MHC class II *induction* during macrophage activation . Positive_regulation TNF NOS2 9278945 450995 IFN gamma/ LPS induced iNOS mRNA levels were effected less than were mRNA levels *induced* by IFN gamma/IL-2 or IFN gamma/ [TNF alpha] . Positive_regulation TNF NOS2 9347218 460580 [TNF-alpha] and IL-6 may be produced in heart failure and may *induce* , resulting in NO production , which acts as a negative inotrope . Positive_regulation TNF NOS2 9405166 469725 However , this low [TNF alpha-concentration] does not suffice to *induce* - documented by reverse transcriptase polymerase chain reaction - or enhance nitrite concentrations in the cell culture supernatants as a measure of cellular NO production , neither in the presence nor absence of dexamethasone ( 0.1 micro M ) . Positive_regulation TNF NOS2 9794913 543195 Hepatocellular , but not bile duct , injury occurs during experimental pancreatitis that is associated with hepatic TNF- , IL-1beta , and mRNA gene *induction* , as well as [TNF-] protein and nitrite production . Positive_regulation TNF NOS3 10747895 690600 Here we show that *regulates* [tumor necrosis factor alpha (TNFalpha)] through a mechanism dependent on the production of O ( 2 ) and completely independent of NO . Positive_regulation TNF NOS3 10747895 690602 Expression of in transfected U937 cells *increased* phorbol 12-myristate 13-acetate induced [TNFalpha] promoter activity and TNFalpha production . Positive_regulation TNF NOS3 11085984 786350 *Activation* of the endothelial by [tumor necrosis factor-alpha] . Positive_regulation TNF NOS3 11224628 787963 In contrast , expression is *induced* by IL-1 , [tumor necrosis factor] , and gamma interferon , a T-helper 1 cytokine profile . Positive_regulation TNF NOS3 11399519 824224 Interferon (IFN)-gamma and Herpes simplex [virus/tumor necrosis factor-alpha] synergistically *induce* 2 in macrophages through cooperative action of nuclear factor-kappa B and IFN regulatory factor-1 . Positive_regulation TNF NOS3 11443053 833688 Expression of in transfected U-937 cells *upregulates* phorbol 12-myristate 13-acetate ( PMA ) -induced [tumor necrosis factor-alpha (TNF-alpha)] production through a superoxide ( O ( 2 ) ( - ) ) -dependent mechanism . Positive_regulation TNF NOS3 11443053 833734 Finally , PD-98059 , a p42/44 MAPK pathway inhibitor , blocked [TNF-alpha] *upregulation* by ( P = 0.02 ) . Positive_regulation TNF NOS3 12506117 1056908 Endothelial *enhances* lipopolysaccharide stimulated [tumor necrosis factor-alpha] expression via cAMP mediated p38 MAPK pathway in cardiomyocytes . Positive_regulation TNF NOS3 12506117 1056936 The purpose of this study was to investigate the *role* of , cAMP , and p38 MAPK in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Positive_regulation TNF NOS3 12506117 1056951 In conclusion , *enhances* LPS stimulated [TNF-alpha] expression in cardiomyocytes . Positive_regulation TNF NOS3 12720581 1084114 In a macrophage cell line ( RAW 264.7 ) activated with interferon gamma plus lipopolysaccharide , both isoflavones were found to *inhibit* NO production and [tumour necrosis factor alpha (TNF-alpha)] secretion dose-dependently , but they did not affect mRNA levels for inducible and cyclo-oxygenase-2 . Positive_regulation TNF NOS3 15501965 1327223 We investigated the *role* of endothelial in determining the tumor-selective activity of [TNF] . Positive_regulation TNF NOS3 16421203 1554182 Functional link between [TNF] biosynthesis and CaM dependent *activation* of inducible in RAW 264.7 macrophages . Positive_regulation TNF NOS3 17466955 1761299 *Role* of neuronal in lipopolysaccharide induced [tumor necrosis factor-alpha] expression in neonatal mouse cardiomyocytes . Positive_regulation TNF NOS3 20504765 2289239 Moreover , [tumor necrosis factor] alpha induced nuclear translocation of CLIC4 is *dependent* on activity . Positive_regulation TNF NOS3 22005300 2503242 Surprisingly , MDL-1 induced NO and [TNF-a] production *required* but not iNOS . Positive_regulation TNF NOS3 23266106 2741428 NF-?B p50 gene deletion blocked NF-?B activation , *inhibited* [TNF-a] expression , prevented down-regulation and reversed the impaired endothelium dependent vasodepressor response induced by CIH . Positive_regulation TNF NOS3 23427281 2887209 The [TNF-a] *induces* and MMP-9 expression and PKB activation . Positive_regulation TNF NOS3 24194350 2868556 Further , candesartan in combination with tPA increased activity of MMP-9 but decreased MMP-3 , nuclear factor kappa-B and [tumor necrosis factor-a] expression and enhanced *activation* of endothelial . Positive_regulation TNF NOS3 24905701 2952074 Furthermore , HMGB1 and IL-1ß and/or [tumor necrosis factor] a ( but not HMGI/Y ) also significantly *induced* inducible , NO , and interleukin (IL)-8 production in human cartilage and chondrocytes . Positive_regulation TNF NOS3 8737749 376964 Here we show that in cultured bovine chondrocytes and explants of human osteoarthritic cartilage both and cyclooxygenase activities were *induced* by the inflammatory mediators , lipopolysaccharide , and interleukin-1 beta or [tumor necrosis factor-alpha] . Positive_regulation TNF NOS3 9133471 427250 IL-1 , [tumor necrosis factor-alpha] , and inducible *increased* slowly until day 7 , declining thereafter . Positive_regulation TNF NOTCH1 14586405 1159558 We found that [TNF] *induced* the expression of , Notch-4 , and Jagged-2 in RSF . Positive_regulation TNF NOTCH1 21593384 2441521 With regard to pDCs , activation *induced* [TNF-a] whereas Notch inhibition significantly abrogated the secretion of CCL19 , CXCL9 , CXCL10 , and TNF-a . Positive_regulation TNF NOTCH1 22205705 2558864 Importantly , overexpression of constituted active form of ( NICD1 ) and Notch2 ( NICD2 ) *suppressed* production of TLR4 triggered proinflammatory cytokines such as [TNF-a] and IL-6 but promoted production of antiinflammatory cytokine IL-10 , which is dependent on the PEST domain of NICD . Positive_regulation TNF NOTCH2 21593384 2441522 With regard to pDCs , Notch activation *induced* [TNF-a] whereas inhibition significantly abrogated the secretion of CCL19 , CXCL9 , CXCL10 , and TNF-a . Positive_regulation TNF NOTCH2 22205705 2558865 Importantly , overexpression of constituted active form of Notch1 ( NICD1 ) and ( NICD2 ) *suppressed* production of TLR4 triggered proinflammatory cytokines such as [TNF-a] and IL-6 but promoted production of antiinflammatory cytokine IL-10 , which is dependent on the PEST domain of NICD . Positive_regulation TNF NOTCH3 21593384 2441523 With regard to pDCs , activation *induced* [TNF-a] whereas Notch inhibition significantly abrogated the secretion of CCL19 , CXCL9 , CXCL10 , and TNF-a . Positive_regulation TNF NOTCH4 14586405 1159559 We found that [TNF] *induced* the expression of Notch-1 , , and Jagged-2 in RSF . Positive_regulation TNF NOTCH4 21593384 2441524 With regard to pDCs , Notch activation *induced* [TNF-a] whereas inhibition significantly abrogated the secretion of CCL19 , CXCL9 , CXCL10 , and TNF-a . Positive_regulation TNF NOX1 14967724 1212157 Cilostazol ( 1 to 100 micromol/L ) significantly suppressed not only *dependent* superoxide production but also [TNF-alpha] and interleukin-1beta release and restored viability . Positive_regulation TNF NOX1 15897117 1408548 Inhibition of by apocynin and p38 phosphorylation by SB203580 could both effectively *block* AOPP-BSA induced [TNF-alpha] secretion . Positive_regulation TNF NOX1 1618916 191400 *Activation* of the by phorbol myristate acetate , F- , N-formyl-methionyl-leucyl-phenylalanine ( FMLP ) , or [tumor necrosis factor (TNF)] dramatically reduced autofluorescence levels . Positive_regulation TNF NOX1 17588511 1764385 In a recent issue of Molecular Cell , Kim et al. ( 2007 ) reported on a novel [TNF] receptor 1 necrotic signaling complex *inducing* TRADD- and RIP1 dependent recruitment and activation of the ROS generating NADPH oxidase complex . Positive_regulation TNF NOX1 18715150 2011855 Furthermore , inhibition of *attenuated* Tat induced release of interleukin-6 (IL-6) , [tumor necrosis factor alpha (TNF)] , and monocyte chemoattractant protein 1 ( MCP-1 ) , and decreased microglial mediated neurotoxicity . Positive_regulation TNF NOX1 18929641 1994579 Interleukin-1beta , flagellin , interferon-gamma , and [tumor necrosis factor alpha (TNF-alpha)] similarly *induced* in a colon cancer cell line ( T84 ) , whereas only TNF-alpha fully induced NOXO1 and upregulated superoxide producing activity by ninefold . Positive_regulation TNF NOX1 19318376 2087129 mediated calpain-1 activation *induces* caspase-3 activation and [TNF-alpha] expression in cardiomyocytes during LPS stimulation . Positive_regulation TNF NOX1 23639811 2805071 In vivo , c-Src-KO mice also had impaired TNF-a and NF-?B responses following partial lobar liver I/R. Studies in NOX1 and p47phox knockout primary hepatocytes demonstrated that both and p47phox are partially *required* for H/R mediated [TNF-a] production . Positive_regulation TNF NOX1 23639811 2805084 Thus Kupffer cell derived factors and NOX2 act to suppress hepatic *dependent* [TNF-a] production . Positive_regulation TNF NOX1 24371447 2882035 We conclude that propofol modulates LPS signaling in macrophages by reducing *mediated* production of [TNF-a] and IL-6 . Positive_regulation TNF NOX3 14967724 1212158 Cilostazol ( 1 to 100 micromol/L ) significantly suppressed not only *dependent* superoxide production but also [TNF-alpha] and interleukin-1beta release and restored viability . Positive_regulation TNF NOX3 15897117 1408549 Inhibition of by apocynin and p38 phosphorylation by SB203580 could both effectively *block* AOPP-BSA induced [TNF-alpha] secretion . Positive_regulation TNF NOX3 1618916 191401 *Activation* of the by phorbol myristate acetate , F- , N-formyl-methionyl-leucyl-phenylalanine ( FMLP ) , or [tumor necrosis factor (TNF)] dramatically reduced autofluorescence levels . Positive_regulation TNF NOX3 17588511 1764386 In a recent issue of Molecular Cell , Kim et al. ( 2007 ) reported on a novel [TNF] receptor 1 necrotic signaling complex *inducing* TRADD- and RIP1 dependent recruitment and activation of the ROS generating Nox1 complex . Positive_regulation TNF NOX3 18715150 2011856 Furthermore , inhibition of *attenuated* Tat induced release of interleukin-6 (IL-6) , [tumor necrosis factor alpha (TNF)] , and monocyte chemoattractant protein 1 ( MCP-1 ) , and decreased microglial mediated neurotoxicity . Positive_regulation TNF NOX3 19318376 2087130 mediated calpain-1 activation *induces* caspase-3 activation and [TNF-alpha] expression in cardiomyocytes during LPS stimulation . Positive_regulation TNF NOX3 24371447 2882036 We conclude that propofol modulates LPS signaling in macrophages by reducing *mediated* production of [TNF-a] and IL-6 . Positive_regulation TNF NOX4 14967724 1212159 Cilostazol ( 1 to 100 micromol/L ) significantly suppressed not only *dependent* superoxide production but also [TNF-alpha] and interleukin-1beta release and restored viability . Positive_regulation TNF NOX4 15897117 1408550 Inhibition of by apocynin and p38 phosphorylation by SB203580 could both effectively *block* AOPP-BSA induced [TNF-alpha] secretion . Positive_regulation TNF NOX4 1618916 191402 *Activation* of the by phorbol myristate acetate , F- , N-formyl-methionyl-leucyl-phenylalanine ( FMLP ) , or [tumor necrosis factor (TNF)] dramatically reduced autofluorescence levels . Positive_regulation TNF NOX4 17588511 1764387 In a recent issue of Molecular Cell , Kim et al. ( 2007 ) reported on a novel [TNF] receptor 1 necrotic signaling complex *inducing* TRADD- and RIP1 dependent recruitment and activation of the ROS generating Nox1 complex . Positive_regulation TNF NOX4 18715150 2011857 Furthermore , inhibition of *attenuated* Tat induced release of interleukin-6 (IL-6) , [tumor necrosis factor alpha (TNF)] , and monocyte chemoattractant protein 1 ( MCP-1 ) , and decreased microglial mediated neurotoxicity . Positive_regulation TNF NOX4 19318376 2087131 mediated calpain-1 activation *induces* caspase-3 activation and [TNF-alpha] expression in cardiomyocytes during LPS stimulation . Positive_regulation TNF NOX4 24371447 2882037 We conclude that propofol modulates LPS signaling in macrophages by reducing *mediated* production of [TNF-a] and IL-6 . Positive_regulation TNF NOX5 14967724 1212156 Cilostazol ( 1 to 100 micromol/L ) significantly suppressed not only *dependent* superoxide production but also [TNF-alpha] and interleukin-1beta release and restored viability . Positive_regulation TNF NOX5 15897117 1408547 Inhibition of by apocynin and p38 phosphorylation by SB203580 could both effectively *block* AOPP-BSA induced [TNF-alpha] secretion . Positive_regulation TNF NOX5 1618916 191399 *Activation* of the by phorbol myristate acetate , F- , N-formyl-methionyl-leucyl-phenylalanine ( FMLP ) , or [tumor necrosis factor (TNF)] dramatically reduced autofluorescence levels . Positive_regulation TNF NOX5 17588511 1764383 In a recent issue of Molecular Cell , Kim et al. ( 2007 ) reported on a novel [TNF] receptor 1 necrotic signaling complex *inducing* TRADD- and RIP1 dependent recruitment and activation of the ROS generating Nox1 complex . Positive_regulation TNF NOX5 18715150 2011854 Furthermore , inhibition of *attenuated* Tat induced release of interleukin-6 (IL-6) , [tumor necrosis factor alpha (TNF)] , and monocyte chemoattractant protein 1 ( MCP-1 ) , and decreased microglial mediated neurotoxicity . Positive_regulation TNF NOX5 19318376 2087127 mediated calpain-1 activation *induces* caspase-3 activation and [TNF-alpha] expression in cardiomyocytes during LPS stimulation . Positive_regulation TNF NOX5 24371447 2882034 We conclude that propofol modulates LPS signaling in macrophages by reducing *mediated* production of [TNF-a] and IL-6 . Positive_regulation TNF NOXO1 18929641 1994578 Interleukin-1beta , flagellin , interferon-gamma , and tumor necrosis factor alpha (TNF-alpha) similarly induced Nox1 in a colon cancer cell line ( T84 ) , whereas only [TNF-alpha] fully *induced* and upregulated superoxide producing activity by ninefold . Positive_regulation TNF NPEPPS 10450013 637494 Moreover , the higher spontaneous and *induced* secretion of [TNFalpha] in BPH patients may reflect a role for this proinflammatory cytokine in vivo . Positive_regulation TNF NPEPPS 10687142 669916 Significantly less encapsulated into liposomes ( Lipo-OK-PSA ) than OK-PSA alone ( 1/100 or less of OK-PSA alone ) was *required* to induce IFN-gamma , [tumor necrosis factor-alpha (TNF-alpha)] , TNF-beta , interleukin-1 beta (IL-1 beta) , natural killer , and lymphokine activated killer activities by human peripheral blood mononuclear cells and mouse spleen cells . Positive_regulation TNF NPEPPS 10996034 733706 In in vitro experiments using human peripheral blood mononuclear cells ( PBMC ) , *induced* IFN-gamma , interleukin (IL)-2 , IL-12 , IL-18 , [tumor necrosis factor (TNF)-alpha] and TNF-beta that are generally called `` Th1-type cytokines '' both in protein and in mRNA levels . Positive_regulation TNF NPPA 11988488 936318 Human umbilical vein endothelial cells ( HUVECs ) were treated with [TNF-alpha] in the *presence* or absence of . Positive_regulation TNF NPPA 15618455 1387720 Bovine pulmonary microvascular ( MVEC ) and macrovascular endothelial cell ( LEC ) monolayers were stimulated with hypoxia , [TNF-alpha] , or bacterial endotoxin ( LPS ) in the *presence* or absence of , and albumin flux , NF-kappa B activation , TNF-alpha secretion , p38 mitogen activated protein kinase (MAPK) , and F-actin ( stress fiber ) formation were assessed . Positive_regulation TNF NPPA 18186083 1863097 However , does not *induce* NO synthase Type 2 (NOS-2) or [tumor necrosis factor-alpha] expression and is able to decrease lipopolysaccharide (LPS) elicited induction of these inflammatory genes . Positive_regulation TNF NPPA 21130119 2390083 *induced* the release of histamine and [TNF-a] from RPMCs and enhanced serotonin release from MPMCs , in a dose dependent fashion , as well as reduced cAMP level of RPMCs in vitro . Positive_regulation TNF NPR1 15710627 1402739 Our results show that reduced signaling *activates* MMP , transforming growth factor-beta1 , and [TNF-alpha] expression in Npr1-/- mouse hearts . Positive_regulation TNF NPS 16492228 1528636 The transient increase in sICAM-1 and [TNF-alpha] found in the internal jugular blood of MWoA patients assessed ictally can be *induced* by sensory released from activated trigeminal endings . Positive_regulation TNF NPS 20933561 2369021 In PAMs , could *induce* the production of the pro-inflammatory cytokines IL-1ß , IL-6 and [TNF-a] . Positive_regulation TNF NPS 21644818 2481094 Bare effectively *stimulated* the production of [IL-1ß/IL-6/TNF-a/IL-8] by monocytes and of IL-8 by polymorphonuclear leukocytes ( PMNs ) . Positive_regulation TNF NPS 21645642 2509851 Here , we report that ceramic zirconia and silicon nitride interfere with MG63 cells ' function and remarkably *stimulate* the secretion of [TNF-a] in RAW264.7 cells . Positive_regulation TNF NPS 22939914 2683767 In addition , the secretion levels of [TNF-a] , IL-1ß and IL-6 were variably *increased* by all four . Positive_regulation TNF NPTX1 24195381 2864367 Moreover , *increased* the [TNF-alpha] mRNA expression , but not contributed to cytokine IL-6 secretion . Positive_regulation TNF NPY 24108115 2852588 Here , we investigated if expression during inflammation is *induced* by [tumor necrosis factor (TNF)] , the main proinflammatory cytokine . Positive_regulation TNF NPY 8982099 403810 The [TNF alpha] production was *stimulated* by and somatostatin in young subjects , and by NPY , somatostatin and VIP in old ones , whereas GRP produced a decrease of TNF alpha in young persons . Positive_regulation TNF NPY4R 19778233 2141048 The induction of [TNF-alpha] and TGF-beta1 by silica was *suppressed* by Src inhibitor ( ) , ERK inhibitor ( PD98059 ) , but not by p38 kinase inhibitor ( SB203580 ) . Positive_regulation TNF NPY4R 24089494 2848144 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed [TNF] receptor 1 and *requires* activation of p38 MAPK , phosphatidylinositol 3-kinase , protein , and dynamin GTPase . Positive_regulation TNF NPY5R 14599717 1161299 Y1 and Y2 receptors were expressed in basal conditions , and LPS , [TNF-alpha] and IFN-gamma *induced* expression with a concomitant extinction of Y2 receptor expression . Positive_regulation TNF NPY6R 12707358 1082850 A protein kinase C ( PKC ) inhibitor ( staurosporine ) , tyrosine kinase inhibitors ( genistein and herbimycin A ) , or a Src kinase inhibitor ( ) *attenuated* [TNF-alpha-] or 12-O-tetradecanoylphorbol-13-acetate ( TPA ) -induced COX-2 promoter activity . Positive_regulation TNF NPY6R 24470356 2913205 It is also presented that pannexin-1 hemichannel function and potential heterodimers are not *involved* in P2X7 dependent release of IL-6 , CCL2 , and [TNF-a] in microglia . Positive_regulation TNF NQO1 16682409 1584041 The purpose of our study was to determine the *role* of in [TNF] cell signaling by using keratinocytes derived from wild-type and NQO1 gene deleted mice . Positive_regulation TNF NQO1 18981090 1983353 Silencing expression of alone , or in combination with heme oxygenase-1 (HO-1) silencing , markedly *increased* LPS induced [TNF] and IL-1beta expression . Positive_regulation TNF NQO1 18981090 1983355 Additionally , overexpression of and/or HO-1 *inhibited* LPS induced [TNF] and IL-1beta expression . Positive_regulation TNF NR0B1 12105854 962904 induced *up-regulation* of colonic [TNF-alpha] and IFN-gamma were significantly suppressed in animals given the anti-MIF antibody . Positive_regulation TNF NR0B1 15630159 1349387 In addition , *induced* increases in colonic mucosal IL-1beta , but not [TNF-alpha] , protein levels were significantly abrogated in 1 % AOB fed mice ( P < 0.05 ) . Positive_regulation TNF NR0B1 23061565 2706571 In addition , *induced* expression of [tumor necrosis factor-a] , interleukin (IL)-6 , and IL-1ß was significantly decreased . Positive_regulation TNF NR0B1 25276218 2959039 AC-mix potently suppressed *induced* body weight loss , colon shortening , myeloperoxidase activity , and [TNF-a] , IL-1ß , and IL-6 expressions in acute or chronic DSS stimulated colitic mice . Positive_regulation TNF NR1I3 18032544 1860775 activation *increases* [TNF] production by mTAL cells via a Gi-dependent mechanism . Positive_regulation TNF NR3C2 11218571 785931 The compounds showed also inhibitor properties with regard to lipopolysaccharide (LPS)- and *induced* [TNF-alpha] production . Positive_regulation TNF NR3C2 21885118 2491567 Conditioned media ( 1° MLR ) collected at 72 h from resting PBMC demonstrated no immunomodulatory effects whereas the control demonstrated significant ( p < 0.001 ) pro-proliferative potential and significantly *increased* in IL-2 , [TNF-a] , and INF-? . Positive_regulation TNF NR3C2 7827283 285740 Together these data suggest that the suppression of by IL-10 *requires* the effective inhibition of both IL-2 and [TNF-alpha] production to suppress a synergy between these two cytokines . Positive_regulation TNF NR4A1 19213954 2050043 These results indicate that negatively *regulates* the [TNF-alpha-] and interleukin-1beta induced vascular EC activation by transcriptionally upregulation of IkappaBalpha expression . Positive_regulation TNF NRAS 17059425 1683924 Zoledronate reduced Ras prenylation , and RhoA translocation to the membrane , and sustained ERK1/2 phosphorylation and [tumor necrosis factor (TNF)] *induced* JNK phosphorylation . Positive_regulation TNF NRAS 17994109 1851151 [TNF-alpha] triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs , and *induced* , p38 MAPK , ERK 1/2 , SAPK/JNK and Akt activation , while increasing proliferation and migration . Positive_regulation TNF NTRK1 18794379 1986509 Furthermore , K252a , a inhibitor , and PD98059 ( 2'-amino-3'-methoxyflavone ) , an ERK1/2 inhibitor , *inhibited* the toxin induced release of [TNF-alpha] from neutrophils . Positive_regulation TNF NTRK1 18794379 1986512 The observation shows that the toxin induced release of [TNF-alpha] is *dependent* on the activation of ERK/mitogen activated protein kinase signal transduction via in neutrophils and that ERM specifically blocks the toxin induced events through the activation of neutrophils . Positive_regulation TNF NUMBL 18299187 1896727 Overexpression of *inhibited* [TNFalpha] , IL-1beta induced activation of NF-kappaB signaling pathway . Positive_regulation TNF NUP43 11443053 833720 Finally , PD-98059 , a MAPK pathway inhibitor , *blocked* [TNF-alpha] upregulation by eNOS ( P = 0.02 ) . Positive_regulation TNF NUP43 11675405 873239 The increase in [TNF-alpha] was *attenuated* by both a inhibitor , PD098059 ( 10 ( -6 ) M ) , and a p38 inhibitor , SB203580 ( 10 ( -6 ) M ) , and AP-1 binding activity was inhibited by PD098059 . Positive_regulation TNF NUP43 11777983 899887 Furthermore , IL-17 , IL-1beta , and [TNF-alpha] *induced* a rapid activation of extracellular signal related kinase and p38 MAPKs , and specific MAPK inhibitors ( SB203580 , PD98059 , and U0216 ) significantly reduced IL-17- , IL-1beta- , or TNF-alpha induced IL-6 secretion , indicating the role of MAPKs in the induction of IL-6 . Positive_regulation TNF NUP43 12060576 952770 Strikingly , the *activation* of ( mapk/erk2 ) and Akt by [TNF-alpha] was also inhibited in the presence of NaCl . Positive_regulation TNF NUP43 12160518 971797 [TNF-alpha] downregulated ACE , which effect was probably *mediated* by both and p38 MAPK pathways . Positive_regulation TNF NUP43 15302094 1283831 Selective MAPK inhibitor could *reduce* the Pb- and LPS triggered [TNF-alpha] expression in U-373MG cells . Positive_regulation TNF NUP43 15365619 1334207 Rosiglitazone treatment impaired [TNF-alpha] *activation* of p38 and , restoring insulin signalling and leading to normalisation of glucose uptake . Positive_regulation TNF NUP43 24441870 2922960 On the other hand , [TNF-a] could *induce* Akt and MAPK translocation from the cytosol into the nucleus , which was inhibited by AG490 , AG1296 , or LY294002 . Positive_regulation TNF NUP43 9885438 558288 On the other hand , [TNF] selectively *induced* tyrosine phosphorylation of , and PMA selectively induced that of p44 and p42 . Positive_regulation TNF OAS1 8551280 339929 These results suggest that [tumor necrosis factor-alpha] and interferon-gamma inhibit hepatitis B virus replication by blocking some step in reverse transcription and that the <2',5'-oligoadenylate synthetase> is not *involved* in the mechanism underlying the inhibition by these two cytokines . Positive_regulation TNF OAS2 8551280 339930 These results suggest that [tumor necrosis factor-alpha] and interferon-gamma inhibit hepatitis B virus replication by blocking some step in reverse transcription and that the <2',5'-oligoadenylate synthetase> is not *involved* in the mechanism underlying the inhibition by these two cytokines . Positive_regulation TNF OAS3 8551280 339931 These results suggest that [tumor necrosis factor-alpha] and interferon-gamma inhibit hepatitis B virus replication by blocking some step in reverse transcription and that the <2',5'-oligoadenylate synthetase> is not *involved* in the mechanism underlying the inhibition by these two cytokines . Positive_regulation TNF ODC1 12667485 1075594 Previously we reported that intermittent intraperitoneal administration of *inducing* factor ( ODC factor ) , interleukin 1alpha (IL-1alpha) , and [tumor-necrosis factor-alpha (TNF-alpha)] to normal mice induced biological changes in the hosts which included changes in the pattern of expression of pyruvate kinase ( PK ) isozymes in the liver and hypertrophy of the spleen . Positive_regulation TNF ODC1 1385320 200743 IL-1 alpha , IL-1 beta , [TNF alpha] and TNF beta *induced* HDC and , as does LPS . Positive_regulation TNF ODC1 15281225 581730 These substances also significantly inhibited the tumor-promoter stimulated inflammation , [TNF-alpha] production , and *activation* of epidermal in mice . Positive_regulation TNF ODC1 8300853 248681 When used individually , however , only IL-1 alpha ( 79 +/- 3 % ) , IFN-gamma ( 70 +/- 2 % ) and [TNF-alpha] ( 65 +/- 5 % ) *induced* hsp72 expression in mixed glial cell cultures . Positive_regulation TNF OLR1 17939209 1813861 expression *increased* also through oxygen species ( ROS ) , endothelin-1 (ET-1) , [tumor necrosis factor-alpha (TNF-alpha)] , shear stress , activation of protein kinase-C ( PKC ) , angiotensin-II (ANG-II) , and through inflammatory pathways . Positive_regulation TNF OLR1 20139626 2213735 Leonurus sibiricus herb extract suppresses oxidative stress and ameliorates hypercholesterolemia in C57BL/6 mice and [TNF-alpha] *induced* expression of adhesion molecules and in human umbilical vein endothelial cells . Positive_regulation TNF OMP 14622404 1169167 induced inflammatory cytokine responses of interleukin (IL)-8 , IL-6 and tumour necrosis factor (TNF)alpha in epithelial cells , and *induced* IL-1beta and [TNFalpha] production in mouse macrophages . Positive_regulation TNF OMP 15383598 1298961 Lipidated ( L ) <-Omp16> and L-Omp19 , but not their unlipidated forms , *induced* the secretion of [TNF-alpha] , IL-6 , IL-10 , and IL-12 in a time- and dose dependent fashion . Positive_regulation TNF OMP 17635859 1793057 In light of these data , we propose a model in which virulent Brucella alters the maturation and functions of DCs through *dependent* control of [TNF-alpha] production . Positive_regulation TNF OPA1 12171446 974209 Proinflammatory IL-1beta *increased* more than 6-fold and [TNF-alpha] 30-fold ( p = 0.001 ) . Positive_regulation TNF OPA1 17456789 1761125 An interaction of histone deacetylase 3 (HDAC3) and silencing for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was *induced* by [TNF-alpha] and observed in a chromatin immunoprecipitation assay . Positive_regulation TNF OPA1 9288135 452455 We hypothesized that IL-1 and [TNF] production in the lungs is essential to the development of ARDS and is *induced* by a released from the inflamed pancreas . Positive_regulation TNF OPN1LW 10760264 683517 Here , we show that induction of [tumor necrosis factor alpha (TNF-alpha)] gene expression in T cells stimulated by engagement of the T cell receptor ( TCR ) or by virus infection *requires* . Positive_regulation TNF OPN1LW 19853841 2165461 Furthermore , in vivo bioassay tests indicated that could remarkably enhance T and B lymphocyte proliferations , augment the phagocytosis of macrophages and *increase* the [tumour necrosis factor-alpha (TNF-alpha)] levels in serum . Positive_regulation TNF OPN1MW 23173851 2822753 Concomitantly , *enhanced* pro-inflammatory cytokine mRNA production , including [tumor necrosis factor-a (Tnfa)] , interleukins (IL)-5 and -23 ( Il6 , Il23 ) , and granulocyte colony stimulating factor ( Gcsf ) . Positive_regulation TNF OPRM1 18349186 1887040 The *mediates* morphine induced [tumor necrosis factor] and interleukin-6 inhibition in toll-like receptor 2-stimulated monocytes . Positive_regulation TNF OPRM1 18349186 1887042 activation specifically *mediated* this morphine induced [TNF] and IL-6 inhibition in monocytes . Positive_regulation TNF OPRM1 18349186 1887046 The *mediates* morphine induced [TNF] and IL-6 inhibition in PGN stimulated monocytes , but not in PBMCs . Positive_regulation TNF OPTN 12379221 997092 expression is also *induced* 2.3-fold by [TNFalpha] and 2.6-fold by prolonged DEX treatment . Positive_regulation TNF OPTN 17702576 1782960 negatively *regulates* [TNFalpha-] induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP . Positive_regulation TNF OSM 20468050 2258010 We also demonstrate that *induced* [TNF-alpha] production from microglia is neurotoxic . Positive_regulation TNF OTC 24426777 2901277 ARPE-19 and primary RPE cells isolated from wild-type , Gpr109a ( -/- ) , or Slc5a8 ( -/- ) mouse eyes were exposed to [TNF-a] in the *presence* or absence of , followed by analysis of IL-6 and Ccl2 expression with real-time quantitative polymerase chain reaction or enzyme linked immunosorbent assay . Positive_regulation TNF OXA1L 16450750 1521996 Both AGE modified beta2m and significantly *increased* [TNF-alpha] and IL-1beta secretion by human PMO in a dose dependent manner ( 50-200 microg/ml ) . Positive_regulation TNF OXA1L 9293394 452857 Similar induction of the synthesis and secretion of [TNF-alpha] and chemotaxis by monocytes in *response* to in vivo may contribute to atherosclerosis in macro- and micro-angiopathy , particularly in the development of chronic clinical complications of diabetes mellitus . Positive_regulation TNF P2RX4 22753954 2676285 We found that pharmacological inhibition of receptors with TNP-ATP *inhibited* transcriptional up-regulation of [TNF-a] and IFN-? in ?d T cells stimulated with anti-CD3/CD28 coated beads or IPP . Positive_regulation TNF P2RX4 24470356 2913206 It is also presented that pannexin-1 hemichannel function and potential heterodimers are not *involved* in P2X7 dependent release of IL-6 , CCL2 , and [TNF-a] in microglia . Positive_regulation TNF P2RX7 17525149 1751383 We further show that activation of receptors can *lead* to the release of [tumor necrosis factor-alpha (TNFalpha)] from satellite cells . Positive_regulation TNF P2RX7 20878769 2363954 Moreover , using RNAi , we demonstrate that Egr factors and receptors are *necessary* for BzATP mediated attenuation of iNOS , and stimulation of [TNF-a] and IL-6 gene expression . Positive_regulation TNF P2RX7 21631954 2446144 These findings suggest that [TNF-a] *induction* by receptor activation may ameliorate SE-induced CA3 neuronal damage via enhancing NF-?B p65-Ser276 and p65-Ser311 phosphorylations . Positive_regulation TNF P2RX7 24470356 2913207 It is also presented that pannexin-1 hemichannel function and potential P2X4/P2X7 heterodimers are not involved in *dependent* release of IL-6 , CCL2 , and [TNF-a] in microglia . Positive_regulation TNF P2RY1 16882655 1625573 activation *induces* release of both [TNFalpha] and PGE2 and blocking either one significantly reduces glutamate release . Positive_regulation TNF P2RY14 22872320 2715689 As for the mechanisms , the inhibition of receptors *resulted* in the release of [tumor necrosis factor (TNF)-a] which then acted on astrocytes to induce MMP-9 . Positive_regulation TNF P4HB 10359811 619644 Studies in which exogenous TNF-alpha was infused into lean mice lacking individual TNFRs indicate that [TNF-alpha] signaling of PAI-1 in adipose tissue can be *mediated* by either the or the p75 TNFR . Positive_regulation TNF P4HB 18475579 290006 The present study was performed to examine whether residues 36-62 of TNFalpha contain the chemotactic domain of TNFalpha , and whether the and p75 TNF receptors are *involved* in [TNFalpha] induced chemotaxis . Positive_regulation TNF P4HB 18680601 1979516 Downregulation of in sepsis and its *role* in [tumor necrosis factor-alpha] release . Positive_regulation TNF P4HB 8145037 252604 A number of recent studies have demonstrated that cellular responses to [tumor necrosis factor (TNF)] *mediated* by the and the p75 TNF receptors are distinct . Positive_regulation TNF P4HB 9551933 499122 In summary , these data help clarify the biologic *roles* of and p75 in mediating and modulating the biologic activity of [TNF] and provide genetic evidence for an antagonistic role of p75 in vivo . Positive_regulation TNF P4HB 9883899 558217 [TNF] signaling can be *mediated* by or p75 TNF receptors . Positive_regulation TNF PABPC1 11116146 786591 NF-kappaB activation by the [tumor necrosis factor receptor (TNFR)] *involves* the formation of a termed a signalosome . Positive_regulation TNF PADI1 24497204 2938244 4 *contributes* to [tumor necrosis factor] a-induced inflammatory arthritis . Positive_regulation TNF PADI2 24497204 2938243 4 *contributes* to [tumor necrosis factor] a-induced inflammatory arthritis . Positive_regulation TNF PADI3 24497204 2938242 4 *contributes* to [tumor necrosis factor] a-induced inflammatory arthritis . Positive_regulation TNF PADI4 24497204 2938245 4 *contributes* to [tumor necrosis factor] a-induced inflammatory arthritis . Positive_regulation TNF PADI6 24497204 2938246 4 *contributes* to [tumor necrosis factor] a-induced inflammatory arthritis . Positive_regulation TNF PAEP 8671447 375124 ( 0.18 and 1.8 nmol/l ) also *increased* [TNF-alpha] production by cells prepared from proliferative tissue , but had no effect on its production by cells prepared from secretory endometrium . Positive_regulation TNF PAF1 10422778 632388 However , exogenously added up to 100 nM did not *stimulate* production of [tumor necrosis factor-alpha] . Positive_regulation TNF PAF1 10435033 634211 [TNF-alpha] in the *presence* of WEB 2170 or CV 3988 , or was studied with the Greiss reagent method . Positive_regulation TNF PAF1 10921504 717354 antioxidants significantly inhibited both the in vivo and in vitro *induced* NF-kappaB activation and NF-kappaB dependent [TNF-alpha] expression . Positive_regulation TNF PAF1 15316260 1286192 The aim of this study was to determine [tumor necrosis factor alpha (TNF-alpha)] and interleukin-6 (IL-6) release in *response* to induction in peripheral blood mononuclear cells ( PBMCs ) from chronic hepatitis B virus ( HBV ) carriers . Positive_regulation TNF PAF1 15316260 1286212 Compared with group A , PBMCs from naturally immune subjects and chronic HBV carriers produced significantly higher amounts of [TNF-alpha] and IL-6 in *response* to . Positive_regulation TNF PAF1 15702351 1382760 Finally , up to 2 mug/ml , did not *induce* the production of pro-inflammatory cytokines such as IL-6 , IL-8 , and [TNF-alpha] . Positive_regulation TNF PAF1 1613396 191105 can *augment* [tumor necrosis factor (TNF)] production by human monocytes in a bimodal manner , with two peaks of activation at picomolar and micromolar concentrations . Positive_regulation TNF PAF1 1613396 191110 Moreover , 6 day- or 7 day differentiated HL-60 cells showed a further increase in [TNF] production in *response* to , and the response was bimodal , similar to that of the less dense subset of monocytes , with peaks at 10 ( -14 ) and 10 ( -7 ) M PAF . Positive_regulation TNF PAF1 1668105 176684 *induced* maximal [TNF alpha] synthesis 2-3 hr after monocyte stimulation as assessed by dot blotting of cell associated TNF alpha using polyclonal anti-TNF antibody . Positive_regulation TNF PAF1 16829183 1591446 Both [TNF-alpha] and IL-1beta induced HUVEC platelet activating factor (PAF) production and was *required* for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine ) . Positive_regulation TNF PAF1 17881124 1802339 The data indicate that these three biochemically unrelated classes of inflammatory repressors act synergistically in modulating induced *up-regulation* of COX-2 , [TNFalpha] , and PGE ( 2 ) by quenching oxidative stress or inflammatory signaling , resulting in increased HN cell survival . Positive_regulation TNF PAF1 1873355 165242 Further , the *role* of released in response to a challenge with LPS in the regulation of [TNF] and IL-6 production was investigated . Positive_regulation TNF PAF1 19769579 2258181 Our previous studies have demonstrated that UVB mediated production of keratinocyte [TNF-alpha] is in part *due* to . Positive_regulation TNF PAF1 20116443 2258831 An immediate low release of PGE ( 2 ) was *induced* by PAF , phorbol ester and arachidonic acid but not by IL1beta , [TNF-alpha] and LPS whereas a delayed high release of PGE ( 2 ) was induced by the inflammatory agents IL1beta , TNF-alpha and LPS but not by , phorbol ester and arachidonic acid . Positive_regulation TNF PAF1 20187806 2216115 However , did not *stimulate* the generation of IL-6 , IL-8 , [TNF-alpha] , and MMP-1 to any significant level and in a consistent manner . Positive_regulation TNF PAF1 20423922 2437233 In rats , [TNF-a] increased hydraulic conductivity 2.5-fold over baseline and *increased* it 5-fold ; Positive_regulation TNF PAF1 2133285 150725 Secretion of [TNF] was *detected* shortly after addition of and was dependent on the PAF concentration used . Positive_regulation TNF PAF1 2133285 150730 While biologically active and cytotoxic [TNF] was *detected* early after addition of , the cytotoxic activity declined thereafter though the antigenic activity remained constant . Positive_regulation TNF PAF1 2133286 150735 We have recently shown that can markedly *enhance* the production of [tumor necrosis factor (TNF)] and interleukin-1 (IL-1) by human monocytes stimulated with lipopolysaccharide or muramyl dipeptide ( MDP ) . Positive_regulation TNF PAF1 2230235 144609 The decrease in plasma [TNF alpha] *induced* by or alprazolam was partly reversed by indomethacin . Positive_regulation TNF PAF1 2266661 147296 Inhibitors of PAF synthesis , such as plasma alpha 1-proteinase inhibitor and an anti-inflammatory peptide , blocked changes induced by TNF , PAF receptor antagonists inhibited changes *induced* by and also by [TNF] . Positive_regulation TNF PAF1 2329280 132459 increased cell associated TNF maximally after 2 to 3 h of incubation and *increased* [TNF] release maximally after 5 to 18 h of incubation . Positive_regulation TNF PAF1 2545780 114296 *enhances* [tumor necrosis factor] production by alveolar macrophages . Positive_regulation TNF PAF1 2545780 114306 *Stimulation* of [TNF] production by was blocked by specific , but structurally different PAF receptor antagonists , BN 52021 , CV3988 and WEB 2086 . Positive_regulation TNF PAF1 2545780 114311 Inhibition of 5-lipoxygenase by nordihydro-guaiaretic acid or AA-861 blocked the *induced* augmentation of both [TNF] and LTB4 production . Positive_regulation TNF PAF1 2545780 114323 Collectively , these data suggest that *enhances* [TNF] production by interaction with a specific putative receptor and by subsequent induction of endogenous 5-lipoxygenase activity in AM . Positive_regulation TNF PAF1 7634340 317037 In addition , significantly *enhanced* LPS induced [TNF alpha] production . Positive_regulation TNF PAF1 7683748 216567 It has also been reported , that murine TNF stimulates the production of platelet activating factor (PAF) by cultured peritoneal macrophages , and that *enhances* [TNF] production by alveolar macrophages . Positive_regulation TNF PAF1 7821968 285549 We have shown previously that endotoxin , tumour necrosis factor (TNF) and platelet activating factor (PAF) are important in the pathogenesis of bowel injury , and that endotoxin and [TNF] *induce* formation in bowel tissue . Positive_regulation TNF PAF1 7895533 299758 also *caused* elevated serum [TNF-alpha] in some control mice but not in C3H/HeJ mice . Positive_regulation TNF PAF1 7930608 274730 Despite increasing RNA for the TNF-alpha gene , *increases* [TNF-alpha] protein levels only in the presence of a costimulus , such as PMA . Positive_regulation TNF PAF1 7930608 274735 We also report that *enhances* PMA induced [TNF-alpha] production from human peripheral B cells . Positive_regulation TNF PAF1 8045673 266906 ET-18-O-OCH3 and *stimulated* [TNF alpha] release by resident BALB/c macrophages in the presence of LPS but not in the absence of this co-factor . Positive_regulation TNF PAF1 8045673 266911 In contrast , both ET-18-O_OCH3 and *stimulated* [TNF alpha] release by thioglycollate elicited macrophages in the absence of LPS although release was greater in the presence of this co-stimulus . Positive_regulation TNF PAF1 8080039 270814 Interleukin-1 beta and [tumor necrosis factor-alpha] *induce* production by endothelium , and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist . Positive_regulation TNF PAF1 8088357 271460 Furthermore , [TNF] production *induced* by itself in vitro was also inhibited in the presence of FR128998 . Positive_regulation TNF PAF1 8514698 221952 Repeated dosing also *resulted* in sustained increased serum [tumor necrosis factor-alpha] levels ( 1,610 +/- 470 pg/ml , P < 0.01 ) and further exacerbation of the leukopenia ( -68 +/- 6 % , P < 0.01 ) and thrombocytopenia ( -65 +/- 8 % , P < 0.01 ) . Positive_regulation TNF PAF1 8704099 371131 We have assessed whether *stimulates* IL-6 and [TNF-alpha] production by human bone marrow stromal cells ( mostly fibroblast-like cells ) . Positive_regulation TNF PAF1 9249487 446829 and 2 ) endogenous [TNF-alpha] is not required for LPS mediated induction of iNOS mRNA , and *mediates* LPS induced APH . Positive_regulation TNF PAF1 9394802 468191 These data suggest that , which is released immediately or shortly after LPS injection , *induces* the expression of [TNF-alpha] through the activation of NF-kappa B . Positive_regulation TNF PAH 21839840 2505623 Scallop implicates in immune response and can be *induced* by human [TNF-a] . Positive_regulation TNF PAIP1 11116146 786588 NF-kappaB activation by the [tumor necrosis factor receptor (TNFR)] *involves* the formation of a termed a signalosome . Positive_regulation TNF PAK1 22268120 2575503 These combined data are consistent with the hypothesis that PPAR? stimulates MUC1/Muc1 expression , thereby blocking *induced* [TNF-a/IL-8] production by airway epithelial cells . Positive_regulation TNF PAK2 22268120 2575504 These combined data are consistent with the hypothesis that PPAR? stimulates MUC1/Muc1 expression , thereby blocking *induced* [TNF-a/IL-8] production by airway epithelial cells . Positive_regulation TNF PAK3 22268120 2575505 These combined data are consistent with the hypothesis that PPAR? stimulates MUC1/Muc1 expression , thereby blocking *induced* [TNF-a/IL-8] production by airway epithelial cells . Positive_regulation TNF PAK4 22268120 2575501 These combined data are consistent with the hypothesis that PPAR? stimulates MUC1/Muc1 expression , thereby blocking *induced* [TNF-a/IL-8] production by airway epithelial cells . Positive_regulation TNF PAK6 22268120 2575502 These combined data are consistent with the hypothesis that PPAR? stimulates MUC1/Muc1 expression , thereby blocking *induced* [TNF-a/IL-8] production by airway epithelial cells . Positive_regulation TNF PAK7 22268120 2575500 These combined data are consistent with the hypothesis that PPAR? stimulates MUC1/Muc1 expression , thereby blocking *induced* [TNF-a/IL-8] production by airway epithelial cells . Positive_regulation TNF PAM 11673494 872770 IFN-beta protein in turn was found to be important for the L-PAM induced up-regulation of TNF-alpha expression , as neutralization of IFN-beta inhibited the induced *up-regulation* of [TNF-alpha] mRNA expression in MOPC-315 tumor cells . Positive_regulation TNF PAM 11673494 872772 Thus , the IFN-beta gene is an early response gene that is activated in response to L-PAM via a pathway that involves reactive oxygen species , and IFN-beta in turn plays an important role in *induced* [TNF-alpha] up-regulation . Positive_regulation TNF PAM 11907116 923274 The median fluorescence intensity for Toll-like receptor 2 cell surface protein was found 2-fold higher on CD14 ( + ) CD16 ( + ) DR ( ++ ) monocytes , which may explain , in part , the higher *induced* [TNF] production by these cells . Positive_regulation TNF PAM 11907116 923275 When analyzing secretion of TNF protein into the supernatant in PBMCs after depletion of CD16 ( + ) monocytes we found a reduction of LPS induced TNF by 28 % but *induced* [TNF] was reduced by 64 % . Positive_regulation TNF PAM 16242370 1518127 The treatment of HUCL cells with TLR2 neutralizing antibody resulted in a significant decrease in *induced* hBD2 production as well as IL-6 , IL-8 , and [TNF-alpha] secretion . Positive_regulation TNF PAM 16783405 1599404 In contrast , S. aureus ( TLR2/TLR1/TLR6 ) or ( 3 ) CSK4 ( TLR2/TLR1 ) , or FSL-1 and LTA ( TLR2/TLR6 ) *induced* [TNFalpha] without an effect on NO. 3 . Positive_regulation TNF PAM 16850005 1600376 In sepsis , [tumor necrosis factor] production in *response* to lipopolysaccharide and was reduced , whereas interleukin-10 production was enhanced . Positive_regulation TNF PAM 16850005 1600378 Monocytes from RCA patients showed a reduced production of [tumor necrosis factor] in *response* to lipopolysaccharide but neither to nor to heat killed bacteria . Positive_regulation TNF PAM 17690330 1842479 Moreover , inhibition of PKR phosphorylation severely impaired [TNF-alpha] and IL-6 production by AM in *response* to LPS and . Positive_regulation TNF PAM 17947654 1814331 Stimulation of naive mouse dendritic cells ( DC ) with LPS or ( 3 ) CSK ( 4 ) ( P3C ) *induces* production of [TNF-alpha] via TLR4- or TLR2 signaling . Positive_regulation TNF PAM 18372043 1892652 However , synergistically *enhanced* upLPS induced DC production of IL-10 but neither IL-12 p40 nor [TNF-alpha] . Positive_regulation TNF PAM 19019456 2016907 Expression of genes associated with the MyD88- ( TNF-alpha , IL-1ss , IL-6 and IL-10 ) and TRIF dependent pathways ( IFN-ss , IP-10 , RANTES and TRAF1 ) were measured at intervals spanning 20 h . LPS and ( 3 ) CSK ( 4 ) *induced* significantly higher expression of [TNF-alpha] , IL-1ss , and IL-10 than did Poly I:C . Positive_regulation TNF PAM 20844955 2401456 IAP-KO whole-blood stimulation with LPS and *resulted* in increased IL-6 and [tumor necrosis factor (TNF)-alpha] secretion compared with WT . Positive_regulation TNF PAM 22525195 2595811 Ciclosporin alone did not alter the expression levels of these transcripts but in the presence of ciclosporin , TNF-a mRNA expression was upregulated in response to all three agonists and both [TNF-a] and IL-8 transcript abundance was increased in *response* to . Positive_regulation TNF PAM 22581266 2669457 We found that in vitro LPS and *induced* [TNF-a] , and IL-6 production are decreased in macrophages from GS/GS mice compared with WT mice ( p < 0.05 ) . Positive_regulation TNF PAM 22823162 2660398 In this study , we demonstrate that the Toll-like receptor-2 agonist , when administered intranasally , triggers a cascade of inflammatory and innate immune signals , acting as an immunostimulant by attracting neutrophils and macrophages and *inducing* secretion of IL-2 , IL-6 , IL-10 , IFN-? , MCP-1 and [TNF-a] . Positive_regulation TNF PAM 23002100 2720173 We demonstrated an increased WLL cell influx , increased IL-6 and chemokine KC ( Cxcl1 ) , and decreased macrophage inflammatory protein (MIP)-1a and [TNF-a] in *response* to as a result of ozone pre-exposure . Positive_regulation TNF PAM 23741282 2878219 *induced* choroid plexus transcription of [TNF-a] and resulted in the most dramatic increase in numbers of white blood cells in the CSF . Positive_regulation TNF PAM 24205328 2864791 Moreover , western blot results showed that TLRs activated PLK1 , and PLK1 inhibition by RNA interference down-regulated *induced* [TNF-a] production , suggesting the involvement of PLK1 in TNF-a up-regulation . Positive_regulation TNF PAM 24205328 2864795 Furthermore , GW843682X inhibited Pam3CSK4 induced activation of ERK and NF-?B , which contributed to *induced* up-regulation of [TNF-a] . Positive_regulation TNF PAM 9486114 476428 The addition of serum led to an increase in LPS- , SAC- and *stimulated* [TNF-alpha] secretion , indicating that the presence of serum is critical not just for LPS stimulation . Positive_regulation TNF PAM 9486114 476429 MY4 , a CD14 antibody , selectively blocked the [TNF-alpha] secretion *induced* by LPS but not by or SAC . Positive_regulation TNF PAN2 8770974 379368 Again , no significant difference was found between NSBD and UPBD in LFA-1 , Mac-1 and CD45 expression on PMN and MNC , during both CU and PAN HD. AFter three hours of dialysis , plasma levels of [TNF-alpha] , but not of IL-6 , were significantly *increased* with CU and . Positive_regulation TNF PAN3 8770974 379369 Again , no significant difference was found between NSBD and UPBD in LFA-1 , Mac-1 and CD45 expression on PMN and MNC , during both CU and PAN HD. AFter three hours of dialysis , plasma levels of [TNF-alpha] , but not of IL-6 , were significantly *increased* with CU and . Positive_regulation TNF PANX1 24470356 2913208 It is also presented that hemichannel function and potential P2X4/P2X7 heterodimers are not *involved* in P2X7 dependent release of IL-6 , CCL2 , and [TNF-a] in microglia . Positive_regulation TNF PAPPA 22997483 2679084 CRP and [TNF-a] *induce* expression in human peripheral blood mononuclear cells . Positive_regulation TNF PARK2 2387094 140900 In vitro treatment of control PBMC with the tuberculin *promoted* an increased [TNF-alpha] production which was similar to that of untreated PBMC from tuberculosis patients . Positive_regulation TNF PARK2 6391657 43416 However , , OK 432 , PSK , and Choreito were unable to *induce* [TNF] activity . Positive_regulation TNF PARK7 2387094 140899 In vitro treatment of control PBMC with the tuberculin *promoted* an increased [TNF-alpha] production which was similar to that of untreated PBMC from tuberculosis patients . Positive_regulation TNF PARK7 6391657 43415 However , , OK 432 , PSK , and Choreito were unable to *induce* [TNF] activity . Positive_regulation TNF PARP1 11403206 824975 inhibition with GPI 6150 blocked the IL-1beta mediated stimulation of both ICAM-1 and E-selectin expression , and *blocked* [TNF-alpha] stimulation of ICAM-1 expression at 24 h . Positive_regulation TNF PARP1 11907276 923570 Our results indicate that [TNF] *induces* activation leading to ATP depletion and subsequent necrosis . Positive_regulation TNF PARP1 14976461 1213081 The production of [TNF- alpha] and IL-12 , but not IL-5 or IL-13 , was also *suppressed* by inhibition . Positive_regulation TNF PARP1 17689746 1842456 These results implicated that activation of in MNC *contributes* to the increases in plasma [TNF-alpha] and IL-10 and is associated with systolic dysfunction of heart after AMI . Positive_regulation TNF PARP1 18996291 1983898 In cultured MNCs from healthy subjects , inhibition of *prevented* lipopolysaccharide induced increase in DNA binding activity of NF-kappaB and the expression of [TNF-alpha] and IL-6 . Positive_regulation TNF PARP1 19454727 2084611 also *regulated* [TNF-alpha] expression and up-regulation of adhesion molecules , further supporting a role of PARP-1 in the inflammatory process within the kidney . Positive_regulation TNF PARP1 23357477 2758528 However , activity *had* no effect on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Positive_regulation TNF PARP1 9639400 514048 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Positive_regulation TNF PARP10 11403206 824970 inhibition with GPI 6150 blocked the IL-1beta mediated stimulation of both ICAM-1 and E-selectin expression , and *blocked* [TNF-alpha] stimulation of ICAM-1 expression at 24 h . Positive_regulation TNF PARP10 11907276 923565 Our results indicate that [TNF] *induces* activation leading to ATP depletion and subsequent necrosis . Positive_regulation TNF PARP10 14976461 1213076 The production of [TNF- alpha] and IL-12 , but not IL-5 or IL-13 , was also *suppressed* by inhibition . Positive_regulation TNF PARP10 17689746 1842451 These results implicated that activation of in MNC *contributes* to the increases in plasma [TNF-alpha] and IL-10 and is associated with systolic dysfunction of heart after AMI . Positive_regulation TNF PARP10 23357477 2758523 However , activity *had* no effect on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Positive_regulation TNF PARP10 9639400 514043 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Positive_regulation TNF PARP11 11403206 824967 inhibition with GPI 6150 blocked the IL-1beta mediated stimulation of both ICAM-1 and E-selectin expression , and *blocked* [TNF-alpha] stimulation of ICAM-1 expression at 24 h . Positive_regulation TNF PARP11 11907276 923562 Our results indicate that [TNF] *induces* activation leading to ATP depletion and subsequent necrosis . Positive_regulation TNF PARP11 14976461 1213073 The production of [TNF- alpha] and IL-12 , but not IL-5 or IL-13 , was also *suppressed* by inhibition . Positive_regulation TNF PARP11 17689746 1842448 These results implicated that activation of in MNC *contributes* to the increases in plasma [TNF-alpha] and IL-10 and is associated with systolic dysfunction of heart after AMI . Positive_regulation TNF PARP11 23357477 2758520 However , activity *had* no effect on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Positive_regulation TNF PARP11 9639400 514040 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Positive_regulation TNF PARP12 11403206 824968 inhibition with GPI 6150 blocked the IL-1beta mediated stimulation of both ICAM-1 and E-selectin expression , and *blocked* [TNF-alpha] stimulation of ICAM-1 expression at 24 h . Positive_regulation TNF PARP12 11907276 923563 Our results indicate that [TNF] *induces* activation leading to ATP depletion and subsequent necrosis . Positive_regulation TNF PARP12 14976461 1213074 The production of [TNF- alpha] and IL-12 , but not IL-5 or IL-13 , was also *suppressed* by inhibition . Positive_regulation TNF PARP12 17689746 1842449 These results implicated that activation of in MNC *contributes* to the increases in plasma [TNF-alpha] and IL-10 and is associated with systolic dysfunction of heart after AMI . Positive_regulation TNF PARP12 23357477 2758521 However , activity *had* no effect on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Positive_regulation TNF PARP12 9639400 514041 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Positive_regulation TNF PARP14 11403206 824979 inhibition with GPI 6150 blocked the IL-1beta mediated stimulation of both ICAM-1 and E-selectin expression , and *blocked* [TNF-alpha] stimulation of ICAM-1 expression at 24 h . Positive_regulation TNF PARP14 11907276 923574 Our results indicate that [TNF] *induces* activation leading to ATP depletion and subsequent necrosis . Positive_regulation TNF PARP14 14976461 1213085 The production of [TNF- alpha] and IL-12 , but not IL-5 or IL-13 , was also *suppressed* by inhibition . Positive_regulation TNF PARP14 17689746 1842460 These results implicated that activation of in MNC *contributes* to the increases in plasma [TNF-alpha] and IL-10 and is associated with systolic dysfunction of heart after AMI . Positive_regulation TNF PARP14 23357477 2758532 However , activity *had* no effect on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Positive_regulation TNF PARP14 9639400 514052 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Positive_regulation TNF PARP15 11403206 824973 inhibition with GPI 6150 blocked the IL-1beta mediated stimulation of both ICAM-1 and E-selectin expression , and *blocked* [TNF-alpha] stimulation of ICAM-1 expression at 24 h . Positive_regulation TNF PARP15 11907276 923568 Our results indicate that [TNF] *induces* activation leading to ATP depletion and subsequent necrosis . Positive_regulation TNF PARP15 14976461 1213079 The production of [TNF- alpha] and IL-12 , but not IL-5 or IL-13 , was also *suppressed* by inhibition . Positive_regulation TNF PARP15 17689746 1842454 These results implicated that activation of in MNC *contributes* to the increases in plasma [TNF-alpha] and IL-10 and is associated with systolic dysfunction of heart after AMI . Positive_regulation TNF PARP15 23357477 2758526 However , activity *had* no effect on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Positive_regulation TNF PARP15 9639400 514046 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Positive_regulation TNF PARP16 11403206 824971 inhibition with GPI 6150 blocked the IL-1beta mediated stimulation of both ICAM-1 and E-selectin expression , and *blocked* [TNF-alpha] stimulation of ICAM-1 expression at 24 h . Positive_regulation TNF PARP16 11907276 923566 Our results indicate that [TNF] *induces* activation leading to ATP depletion and subsequent necrosis . Positive_regulation TNF PARP16 14976461 1213077 The production of [TNF- alpha] and IL-12 , but not IL-5 or IL-13 , was also *suppressed* by inhibition . Positive_regulation TNF PARP16 17689746 1842452 These results implicated that activation of in MNC *contributes* to the increases in plasma [TNF-alpha] and IL-10 and is associated with systolic dysfunction of heart after AMI . Positive_regulation TNF PARP16 23357477 2758524 However , activity *had* no effect on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Positive_regulation TNF PARP16 9639400 514044 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Positive_regulation TNF PARP2 11403206 824977 inhibition with GPI 6150 blocked the IL-1beta mediated stimulation of both ICAM-1 and E-selectin expression , and *blocked* [TNF-alpha] stimulation of ICAM-1 expression at 24 h . Positive_regulation TNF PARP2 11907276 923572 Our results indicate that [TNF] *induces* activation leading to ATP depletion and subsequent necrosis . Positive_regulation TNF PARP2 14976461 1213083 The production of [TNF- alpha] and IL-12 , but not IL-5 or IL-13 , was also *suppressed* by inhibition . Positive_regulation TNF PARP2 17689746 1842458 These results implicated that activation of in MNC *contributes* to the increases in plasma [TNF-alpha] and IL-10 and is associated with systolic dysfunction of heart after AMI . Positive_regulation TNF PARP2 23357477 2758530 However , activity *had* no effect on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Positive_regulation TNF PARP2 9639400 514050 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Positive_regulation TNF PARP3 11403206 824978 inhibition with GPI 6150 blocked the IL-1beta mediated stimulation of both ICAM-1 and E-selectin expression , and *blocked* [TNF-alpha] stimulation of ICAM-1 expression at 24 h . Positive_regulation TNF PARP3 11907276 923573 Our results indicate that [TNF] *induces* activation leading to ATP depletion and subsequent necrosis . Positive_regulation TNF PARP3 14976461 1213084 The production of [TNF- alpha] and IL-12 , but not IL-5 or IL-13 , was also *suppressed* by inhibition . Positive_regulation TNF PARP3 17689746 1842459 These results implicated that activation of in MNC *contributes* to the increases in plasma [TNF-alpha] and IL-10 and is associated with systolic dysfunction of heart after AMI . Positive_regulation TNF PARP3 23357477 2758531 However , activity *had* no effect on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Positive_regulation TNF PARP3 9639400 514051 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Positive_regulation TNF PARP4 11403206 824976 inhibition with GPI 6150 blocked the IL-1beta mediated stimulation of both ICAM-1 and E-selectin expression , and *blocked* [TNF-alpha] stimulation of ICAM-1 expression at 24 h . Positive_regulation TNF PARP4 11907276 923571 Our results indicate that [TNF] *induces* activation leading to ATP depletion and subsequent necrosis . Positive_regulation TNF PARP4 14976461 1213082 The production of [TNF- alpha] and IL-12 , but not IL-5 or IL-13 , was also *suppressed* by inhibition . Positive_regulation TNF PARP4 17689746 1842457 These results implicated that activation of in MNC *contributes* to the increases in plasma [TNF-alpha] and IL-10 and is associated with systolic dysfunction of heart after AMI . Positive_regulation TNF PARP4 23357477 2758529 However , activity *had* no effect on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Positive_regulation TNF PARP4 9639400 514049 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Positive_regulation TNF PARP6 11403206 824974 inhibition with GPI 6150 blocked the IL-1beta mediated stimulation of both ICAM-1 and E-selectin expression , and *blocked* [TNF-alpha] stimulation of ICAM-1 expression at 24 h . Positive_regulation TNF PARP6 11907276 923569 Our results indicate that [TNF] *induces* activation leading to ATP depletion and subsequent necrosis . Positive_regulation TNF PARP6 14976461 1213080 The production of [TNF- alpha] and IL-12 , but not IL-5 or IL-13 , was also *suppressed* by inhibition . Positive_regulation TNF PARP6 17689746 1842455 These results implicated that activation of in MNC *contributes* to the increases in plasma [TNF-alpha] and IL-10 and is associated with systolic dysfunction of heart after AMI . Positive_regulation TNF PARP6 23357477 2758527 However , activity *had* no effect on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Positive_regulation TNF PARP6 9639400 514047 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Positive_regulation TNF PARP8 11403206 824972 inhibition with GPI 6150 blocked the IL-1beta mediated stimulation of both ICAM-1 and E-selectin expression , and *blocked* [TNF-alpha] stimulation of ICAM-1 expression at 24 h . Positive_regulation TNF PARP8 11907276 923567 Our results indicate that [TNF] *induces* activation leading to ATP depletion and subsequent necrosis . Positive_regulation TNF PARP8 14976461 1213078 The production of [TNF- alpha] and IL-12 , but not IL-5 or IL-13 , was also *suppressed* by inhibition . Positive_regulation TNF PARP8 17689746 1842453 These results implicated that activation of in MNC *contributes* to the increases in plasma [TNF-alpha] and IL-10 and is associated with systolic dysfunction of heart after AMI . Positive_regulation TNF PARP8 23357477 2758525 However , activity *had* no effect on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Positive_regulation TNF PARP8 9639400 514045 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Positive_regulation TNF PARP9 11403206 824969 inhibition with GPI 6150 blocked the IL-1beta mediated stimulation of both ICAM-1 and E-selectin expression , and *blocked* [TNF-alpha] stimulation of ICAM-1 expression at 24 h . Positive_regulation TNF PARP9 11907276 923564 Our results indicate that [TNF] *induces* activation leading to ATP depletion and subsequent necrosis . Positive_regulation TNF PARP9 14976461 1213075 The production of [TNF- alpha] and IL-12 , but not IL-5 or IL-13 , was also *suppressed* by inhibition . Positive_regulation TNF PARP9 17689746 1842450 These results implicated that activation of in MNC *contributes* to the increases in plasma [TNF-alpha] and IL-10 and is associated with systolic dysfunction of heart after AMI . Positive_regulation TNF PARP9 23357477 2758522 However , activity *had* no effect on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Positive_regulation TNF PARP9 9639400 514042 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Positive_regulation TNF PAWR 12775717 1119746 Down-regulation of PAR4 expression in microglial cultures by a specific antisense , but not a sense , oligonucleotide reduced *induced* [TNF-alpha] . Positive_regulation TNF PAWR 12775717 1119747 Mechanistic studies indicated that , in comparison with PAR1 signaling , prolonged increase of [ Ca2+ ] i and phosphorylation of p44/42 mitogen activated protein kinases , as well as NFkappaB activation may be responsible for *induced* [TNF-alpha] production in microglia . Positive_regulation TNF PCBD1 11595838 870248 TIMP-3 is the only member which is tightly bound to ECM , inhibits TNF-alpha converting enzyme and *induces* through the stabilization of [TNF-alpha] receptors on the cell surface . Positive_regulation TNF PDB1 10890565 710564 The release of IL-6 and [TNF] from the ZG , ZF , ZR , and medulla was *increased* by , IL-1alpha , IL-1beta , and LPS . Positive_regulation TNF PDB1 15979550 1424663 EACs exhibit basal [TNF-alpha] gene expression and protein secretion and these were *increased* potently by . Positive_regulation TNF PDB1 15979550 1424664 However , neutralization of TNF-alpha by addition of anti-TNF-alpha antibodies did not prevent the suppression of mitogenesis , induction of apoptosis , or *activation* of [TNF-alpha] gene expression by . Positive_regulation TNF PDC 19762779 2163497 Northern blot analysis and ELISA revealed that LPS induced [TNF-alpha] upregulation was strongly *suppressed* by inhibitors , dimethyloxallyl glycine ( DMOG ) , and TM6008 in RAW264.7 macrophages . Positive_regulation TNF PDC 19762779 2163499 inhibition by DMOG or RNA interference *inhibited* LPS induced [TNF-alpha] upregulation in macrophages possibly through NF-kappaB inhibition , which is independent of HIF-1alpha accumulation . Positive_regulation TNF PDCD1 7593233 334597 Interferon-gamma and [tumor necrosis factor-alpha] suppress both early and late stages of hematopoiesis and *induce* . Positive_regulation TNF PDCD10 7593233 334598 Interferon-gamma and [tumor necrosis factor-alpha] suppress both early and late stages of hematopoiesis and *induce* . Positive_regulation TNF PDCD11 7593233 334596 Interferon-gamma and [tumor necrosis factor-alpha] suppress both early and late stages of hematopoiesis and *induce* . Positive_regulation TNF PDCD1LG2 16129490 1507336 Flow cytometric analysis revealed that B7-H1 but not constitutively expresses on TECs , and the B7-H1 protein expression was profoundly *up-regulated* by the stimulation of [TNF-alpha] with a dose dependent manner . Positive_regulation TNF PDCD2 18486760 1910904 Overexpression of the gene *results* in inhibited [TNF-alpha] production in activated Daudi cells . Positive_regulation TNF PDCD2 7593233 334599 Interferon-gamma and [tumor necrosis factor-alpha] suppress both early and late stages of hematopoiesis and *induce* . Positive_regulation TNF PDCD4 7593233 334600 Interferon-gamma and [tumor necrosis factor-alpha] suppress both early and late stages of hematopoiesis and *induce* . Positive_regulation TNF PDCD5 7593233 334601 Interferon-gamma and [tumor necrosis factor-alpha] suppress both early and late stages of hematopoiesis and *induce* . Positive_regulation TNF PDCD6 7593233 334602 Interferon-gamma and [tumor necrosis factor-alpha] suppress both early and late stages of hematopoiesis and *induce* . Positive_regulation TNF PDCD7 7593233 334603 Interferon-gamma and [tumor necrosis factor-alpha] suppress both early and late stages of hematopoiesis and *induce* . Positive_regulation TNF PDE3A 9004165 404867 All three inhibitors , amrinone , pimobendan and vesnarinone , *inhibited* [TNF-alpha] production , but vesnarinone 's inhibitory effect was the most prominent . Positive_regulation TNF PDE3B 9004165 404868 All three inhibitors , amrinone , pimobendan and vesnarinone , *inhibited* [TNF-alpha] production , but vesnarinone 's inhibitory effect was the most prominent . Positive_regulation TNF PDE4B 12032334 948076 Induction of the cyclic nucleotide phosphodiesterase is *essential* for LPS activated [TNF-alpha] responses . Positive_regulation TNF PDE4B 15993984 1546725 Inhibition of *reduces* by up to 70 % the release of [TNF-alpha] from sAbeta stimulated microglial cells , implicating cAMP as an important mediator of Abeta induced microglial activation . Positive_regulation TNF PDE4B 18687753 1973596 These findings strongly support the pathogenic *role* of in the ethanol mediated priming of monocytes/macrophages and increased LPS-inducible [TNF] production and the subsequent development of alcoholic liver disease (ALD) . Positive_regulation TNF PDE7A 19379723 2081944 These results demonstrate that might *regulate* [TNF-alpha] production in keratinocytes in a cAMP dependent fashion . Positive_regulation TNF PDGFA 7751646 306773 [TNF-alpha] *induces* chain gene expression with a maximum at 4 h. DNA synthesis is abrogated in response to TNF-alpha by a goat anti-PDGF IgG but not by nonimmune goat IgG , suggesting induction of an autocrine PDGF-AA loop by TNF-alpha . Positive_regulation TNF PDGFB 12730063 1106747 Functional studies confirmed the senescent dysregulation of TNF-alpha receptor pathways , demonstrating that [TNF-alpha] *induced* expression in cardiac microvascular endothelial cells of 4-mo-old , but not 24-mo-old , rats . Positive_regulation TNF PDIA3 22207023 2549738 This is the first study , which reports the *role* of and hnRNP-H in [TNF-a] production in DENV infected cells . Positive_regulation TNF PDLIM7 17456766 1730240 *up-regulated* [TNF-alpha] through TRAF2 ,5 and nuclear factor-kappaB pathway in T cells . Positive_regulation TNF PEBP1 1722107 173248 Muramyl tripeptide encapsulated in liposomes *stimulates* monocyte production of [tumor necrosis factor] and interleukin-1 in vitro . Positive_regulation TNF PEBP4 1722107 173247 Muramyl tripeptide encapsulated in liposomes *stimulates* monocyte production of [tumor necrosis factor] and interleukin-1 in vitro . Positive_regulation TNF PECAM1 10996391 733872 Early production of [TNFalpha] after liver injury could *induce* an increased ICAM-1-expression and a decreased expression , which might be essential for the transmigration of inflammatory cells into the parenchyma . Positive_regulation TNF PECAM1 18025177 1827643 In this study , we demonstrate that ligation with CD38-Fc fusion protein negatively *regulates* LPS induced proinflammatory cytokine [TNF-alpha] , IL-6 , and IFN-beta production by inhibiting JNK , NF-kappaB , and IFN regulatory factor 3 activation in macrophages . Positive_regulation TNF PECAM1 8144966 252569 Cross linking of neither nor Fc gamma RII molecules with the respective F ( ab ) fragments *induced* [TNF-alpha] release , but nonbinding control IgG1 Ab was able to restore the response of PBMC to 1B5 F ( ab ) fragments , when both Ab preparations were coated concomitantly . Positive_regulation TNF PEG3 11045567 742604 The imprinted gene is not *essential* for [tumor necrosis factor] alpha signaling . Positive_regulation TNF PF4 10590045 572275 In previous studies , we found that specifically binds to human polymorphonuclear granulocytes ( PMN ) , but *requires* [tumor necrosis factor-alpha (TNF-alpha)] as a costimulus for the induction of effector functions in suspended cells . Positive_regulation TNF PF4 7595059 334842 However , ( 58-70 ) did not *enhance* [TNF-alpha] secretion in LPS stimulated whole blood . Positive_regulation TNF PGA3 19294383 2119988 Downregulation of MyD88 and TLR4 expression using small interfering RNA ( siRNA ) significantly inhibited *induced* [TNF-alpha] secretion from the RAW264.7 cells . Positive_regulation TNF PGA3 19514423 2092702 Patients with highly active hepatitis and maximal morphological changes in the liver had significant lowering of NDV induced production of IFN-alpha , IFN-gamma , TNF-alpha , IL-6 and *induced* production of [TNF-alpha] . Positive_regulation TNF PGA4 19294383 2119989 Downregulation of MyD88 and TLR4 expression using small interfering RNA ( siRNA ) significantly inhibited *induced* [TNF-alpha] secretion from the RAW264.7 cells . Positive_regulation TNF PGA4 19514423 2092703 Patients with highly active hepatitis and maximal morphological changes in the liver had significant lowering of NDV induced production of IFN-alpha , IFN-gamma , TNF-alpha , IL-6 and *induced* production of [TNF-alpha] . Positive_regulation TNF PGA5 19294383 2119990 Downregulation of MyD88 and TLR4 expression using small interfering RNA ( siRNA ) significantly inhibited *induced* [TNF-alpha] secretion from the RAW264.7 cells . Positive_regulation TNF PGA5 19514423 2092704 Patients with highly active hepatitis and maximal morphological changes in the liver had significant lowering of NDV induced production of IFN-alpha , IFN-gamma , TNF-alpha , IL-6 and *induced* production of [TNF-alpha] . Positive_regulation TNF PGF 15094384 1238343 [TNF-alpha] reporter activity in FPB cells is *stimulated* by and this is decreased by pretreatment with a chelator of intracellular calcium or by a gap junction inhibitor . Positive_regulation TNF PGF 15094384 1238344 It , therefore , appears that *stimulated* [TNF-alpha] reporter activity in FPB cells is amplified by a Rho dependent mechanism involving calcium , gap junctions , and PKC . Positive_regulation TNF PGF 19180491 2033116 Exogenous specifically *increased* the production of [TNFalpha] and IL-6 in mononuclear cells from RA patients ( but not those from healthy controls ) via a calcineurin dependent pathway . Positive_regulation TNF PGF 19180491 2033120 A novel anti-flt-1 hexapeptide , GNQWFI , abrogated the *induced* increase in [TNFalpha] and IL-6 production , and also suppressed CII induced arthritis and serum IL-6 concentrations in mice . Positive_regulation TNF PGP 7564516 324357 Recombinant cytokines including GM-CSF , G-CSF , IL-1 beta , IL-6 , stem cell factor , LIF , erythropoietin , and IL-3 had no effect on P-gp expression whereas [TNF alpha] *induced* dose- and time dependent and mdr-1 gene overexpression . Positive_regulation TNF PHB 19710421 2144797 inhibits [tumor necrosis factor] alpha *induced* nuclear factor-kappa B nuclear translocation via the novel mechanism of decreasing importin alpha3 expression . Positive_regulation TNF PHEX 20817730 2336413 We identified poly(ADP-ribose) polymerase 1 ( PARP-1 ) binding immediately upstream of the NF-?B sites and showed that [TNF] *induced* poly ( ADP-ribosyl ) ation of RelA when bound to the promoter . Positive_regulation TNF PHOSPHO1 14695331 1195025 levels were low in medium treated FLS , but were rapidly *increased* by interleukin-1 and [tumor necrosis factor-alpha] , although phospho-MKK6 levels only modestly increased . Positive_regulation TNF PHOSPHO2 14695331 1195026 levels were low in medium treated FLS , but were rapidly *increased* by interleukin-1 and [tumor necrosis factor-alpha] , although phospho-MKK6 levels only modestly increased . Positive_regulation TNF PI3 11247802 793346 [TNF-alpha] *induced* marked activation of and Akt/PKB , and the activation of PI3-kinase and Akt/PKB was rapid ( maximal at 10 and 15 min , respectively ) and concentration dependent . Positive_regulation TNF PI3 12055072 951591 A *role* for PKC-delta and in [TNF-alpha] mediated antiapoptotic signaling in the human neutrophil . Positive_regulation TNF PI3 12055072 951603 In this study , a *role* for PKC-delta and in [TNF-alpha] mediated antiapoptotic signaling was examined . Positive_regulation TNF PI3 12055072 951605 Inhibition of by LY-294002 also *inhibited* [TNF-alpha] mediated antiapoptotic signaling . Positive_regulation TNF PI3 12930919 1164056 These effects are mediated through both MEK and pathways but not through the IGF-I *induction* of [TNF-alpha] production by the DC . Positive_regulation TNF PI3 15115707 1279377 These results suggest that delta-PKC and *regulate* [TNF] antiapoptotic signaling at the level of the TNFR-1 through control of assembly of a TNFR-1-TRADD-RIP-TRAF2 complex . Positive_regulation TNF PI3 15703956 1497462 *Activation* of p38 mitogen activated protein (MAP) kinase and by [TNF-alpha] was inhibited with SB202190 and Ly 294002 respectively . Positive_regulation TNF PI3 16081599 1460326 gp120 elicited [TNF-alpha] production was also *blocked* by inhibitors ( wortmannin , LY294002 ) . Positive_regulation TNF PI3 16081599 1460344 These results indicate that gp120 elicited [TNF-alpha] production by macrophages *involves* chemokine receptor mediated and MAPK activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and ERK-1/2 independently regulate TNF-alpha production . Positive_regulation TNF PI3 17607712 1798182 Although [TNF] *induced* the activation of p38 MAPK , JNK , ERK and signaling , these pathways were not crucial for EMD protection of hGFs . Positive_regulation TNF PI3 18207479 1876665 [TNFalpha] signaling *involves* kinase B (PKB) , and p44/42 MAP kinase (MAPK) which are important in NF-kappaB activation . Positive_regulation TNF PI3 23447687 2760340 Selective inhibitors of and PI3Kd markedly *reduced* both the early and late response to fMLF and [TNF] in human neutrophils . Positive_regulation TNF PI3 9892044 558605 The inhibitor wortmannin *blocked* [TNF-alpha] secretion at low doses ( EC50= 13 nM ) , but only partially affected mRNA expression . Positive_regulation TNF PI3 9892044 558606 Our results show that in FcepsilonRI stimulated RBL-2H3 cells calcium mobilization , activation of PKC and PI 3-kinase are necessary for [TNF-alpha] secretion while for the increased TNF-alpha mRNA expression PKC activity is dispensable and activity only partially *required* . Positive_regulation TNF PIAS2 24785276 2937232 ELISA results showed that could *stimulate* the secretion of IL-6 , IFN-a and [TNF-a] from mouse DCs . Positive_regulation TNF PID1 22160469 2568550 *induced* the secretion of FFAs and [TNF-a] and caused mitochondrial dysfunction , which may cause insulin resistance . Positive_regulation TNF PIGA 17898021 1849053 These anionic significantly *increased* the synthesis of [TNF-alpha] ( P < 0.05 ) and IL-6 ( P < 0.05 ) in a dose and time dependent manner . Positive_regulation TNF PIGA 17898021 1849065 While both the p42/p44 MAPK and NF-kappaB pathways are essential in regulating the anionic pIgA induced synthesis of IL-6 , [TNF-alpha] synthesis *mediated* by anionic is partly dependent on NF-kappaB . Positive_regulation TNF PIH 9596861 478246 Our study demonstrated an *increase* of [TNF] level in maternal plasma with . Positive_regulation TNF PIK3C3 11266376 796725 There has been recent speculation on the *activation* of ( PI 3-kinase ) by [TNF-alpha] and its role in the regulation of genes controlled by NF-kappaB . Positive_regulation TNF PIK3C3 11356844 834404 *Activation* of signaling by [tumor necrosis factor (TNF)] activates IKK and NF-kappaB . Positive_regulation TNF PIK3C3 12606779 1062954 Moreover , signal was *required* for excess [TNF-alpha] production in human macrophages derived from THP-1 cells . Positive_regulation TNF PIK3C3 15722197 1374637 The *activation* of NF-kappaB and by [TNF-alpha] and TRAIL overrides the pro-apoptotic effects of these ligands in carcinoma cells and hinders their therapeutic application . Positive_regulation TNF PIK3C3 23538493 2788581 In addition , [TNF-a] *induced* a downregulation of claudin-1 , claudin-2 , claudin-4 , and occludin as well as activation of signaling in T-84 but not Caco-2 cells , which was reversed by adalimumab . Positive_regulation TNF PIK3CA 10559228 566465 CD45 induced [tumor necrosis factor] alpha production in monocytes is *dependent* and nuclear factor-kappaB independent . Positive_regulation TNF PIK3CA 11247802 793336 The *activation* of and Akt/protein kinase B (PKB) by [tumor necrosis factor (TNF)-alpha] and their roles on stimulation of protein synthesis were investigated in cultured neonatal rat cardiac myocytes . Positive_regulation TNF PIK3CA 11328375 807934 The increase in translation of TNF-alpha due to serum could be inhibited by the phosphatidylinositol (PI) 3-K inhibitors , wortmannin and LY294002 , suggesting that is *involved* in the translational control of [TNF-alpha] by serum . Positive_regulation TNF PIK3CA 11337489 827570 We also have shown that [TNF] induces tyrosine phosphorylation and internalization of the overexpressed EGFR in NIH3T3 cells and the endogenously expressed EGFR in A431 cells and that the transactivation by TNF is *suppressed* by N-acetyl-l-cysteine or overexpression of an endogenous reducing molecule , thioredoxin , but not by inhibitors and protein kinase C inhibitor . Positive_regulation TNF PIK3CA 11453646 837061 The inhibitor LY294002 significantly *inhibited* [TNFalpha] activation of Rac as well as Erk and abolished that of the PI3K target Akt , without showing any inhibitory effects on JNK and p38 activation . Positive_regulation TNF PIK3CA 11705740 879443 The inhibitor LY-294002 *blocks* [TNF-alpha-] and Fas mediated Akt phosphorylation . Positive_regulation TNF PIK3CA 14688354 1190714 Inhibition of *resulted* in increased serum levels of IL1-beta , IL-2 , IL-6 , IL-10 , IL-12 , and [TNF-alpha] in septic mice . Positive_regulation TNF PIK3CA 16761312 1590436 GIA activated the phosphatidylinositol 3-kinase (PI3 K)/Akt system and a specific inhibitor of ( LY294002 ) *reduced* sPLA ( 2 ) -induced release of [TNF-alpha] and CXCL8 . Positive_regulation TNF PIK3CA 16777389 1573105 On the other hand , the inhibitor , LY294002 , and epidermal growth factor receptor (EGFR)-specific inhibitor , AG1478 , did not *suppress* the release of [TNF-alpha] . Positive_regulation TNF PIK3CA 17473139 1738296 The inhibitor *reduced* [TNF-alpha] production by 70 % in response to titanium with adherent endotoxin without increasing cytotoxicity . Positive_regulation TNF PIK3CA 17473139 1738301 High concentrations of endotoxin-free titanium particles resulted in a small delayed increase in [TNF-alpha] production that was completely *blocked* by the inhibitor . Positive_regulation TNF PIK3CA 17934470 1819729 Decreased activity inhibits E. coli phagocytosis and *increases* [TNF-alpha] production through Toll-like receptor 4 . Positive_regulation TNF PIK3CA 18826950 1988014 Taken together , these data demonstrate increased constitutive activation of the PI3K signaling pathway in HIV+ macrophages and support the concept that activation ( by HIV proteins such as Nef ) may *contribute* to reduced TLR4 mediated [TNF-alpha] release in HIV+ human macrophages and impair host cell response to infectious challenge . Positive_regulation TNF PIK3CA 20518848 2430862 We conclude that mediated Rac1 activation is *required* for induction of [TNF-a] expression in cardiomyocytes and cardiac dysfunction during endotoxemia . Positive_regulation TNF PIK3CA 21209364 2402356 While investigating the different actors of signalization , we found that p38 kinase and were playing an important *role* in HKSA phagocytosis and [TNF] production . Positive_regulation TNF PIK3CA 21637390 2437147 Both [TNF-a] and IL-6 production by HBHA was *regulated* by the NF-?B , , and MAPK pathways . Positive_regulation TNF PIK3CA 21836068 2495787 Inhibition of *blocked* the effects of TMD23 on chemotactic motility , matrix metalloproteinase-9 , interleukin-8 , and [TNF-a] . Positive_regulation TNF PIK3CA 23188524 2745417 We found that MAPK and Akt inhibitors , but not inhibitor , remarkably *suppressed* ACPA mediated [TNF-a] production . Positive_regulation TNF PIK3CA 24089494 2848142 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed [TNF] receptor 1 and *requires* activation of p38 MAPK , , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation TNF PIK3CD 17644738 1804957 We show here that the catalytic isoform , not p110gamma , was *required* for interferon-gamma (IFN-gamma) , [tumor necrosis factor-alpha (TNF-alpha)] , and granulocyte macrophage colony stimulating factor ( GM-CSF ) secretion , whereas neither was necessary for cytotoxicity . Positive_regulation TNF PIK3R1 10559228 566466 CD45 induced [tumor necrosis factor] alpha production in monocytes is *dependent* and nuclear factor-kappaB independent . Positive_regulation TNF PIK3R1 11247802 793337 The *activation* of and Akt/protein kinase B (PKB) by [tumor necrosis factor (TNF)-alpha] and their roles on stimulation of protein synthesis were investigated in cultured neonatal rat cardiac myocytes . Positive_regulation TNF PIK3R1 11328375 807935 The increase in translation of TNF-alpha due to serum could be inhibited by the phosphatidylinositol (PI) 3-K inhibitors , wortmannin and LY294002 , suggesting that is *involved* in the translational control of [TNF-alpha] by serum . Positive_regulation TNF PIK3R1 11337489 827571 We also have shown that [TNF] induces tyrosine phosphorylation and internalization of the overexpressed EGFR in NIH3T3 cells and the endogenously expressed EGFR in A431 cells and that the transactivation by TNF is *suppressed* by N-acetyl-l-cysteine or overexpression of an endogenous reducing molecule , thioredoxin , but not by inhibitors and protein kinase C inhibitor . Positive_regulation TNF PIK3R1 11453646 837062 The inhibitor LY294002 significantly *inhibited* [TNFalpha] activation of Rac as well as Erk and abolished that of the PI3K target Akt , without showing any inhibitory effects on JNK and p38 activation . Positive_regulation TNF PIK3R1 11705740 879444 The inhibitor LY-294002 *blocks* [TNF-alpha-] and Fas mediated Akt phosphorylation . Positive_regulation TNF PIK3R1 14688354 1190715 Inhibition of *resulted* in increased serum levels of IL1-beta , IL-2 , IL-6 , IL-10 , IL-12 , and [TNF-alpha] in septic mice . Positive_regulation TNF PIK3R1 16761312 1590437 GIA activated the phosphatidylinositol 3-kinase (PI3 K)/Akt system and a specific inhibitor of ( LY294002 ) *reduced* sPLA ( 2 ) -induced release of [TNF-alpha] and CXCL8 . Positive_regulation TNF PIK3R1 16777389 1573106 On the other hand , the inhibitor , LY294002 , and epidermal growth factor receptor (EGFR)-specific inhibitor , AG1478 , did not *suppress* the release of [TNF-alpha] . Positive_regulation TNF PIK3R1 17473139 1738297 The inhibitor *reduced* [TNF-alpha] production by 70 % in response to titanium with adherent endotoxin without increasing cytotoxicity . Positive_regulation TNF PIK3R1 17473139 1738302 High concentrations of endotoxin-free titanium particles resulted in a small delayed increase in [TNF-alpha] production that was completely *blocked* by the inhibitor . Positive_regulation TNF PIK3R1 17934470 1819730 Decreased activity inhibits E. coli phagocytosis and *increases* [TNF-alpha] production through Toll-like receptor 4 . Positive_regulation TNF PIK3R1 18826950 1988015 Taken together , these data demonstrate increased constitutive activation of the PI3K signaling pathway in HIV+ macrophages and support the concept that activation ( by HIV proteins such as Nef ) may *contribute* to reduced TLR4 mediated [TNF-alpha] release in HIV+ human macrophages and impair host cell response to infectious challenge . Positive_regulation TNF PIK3R1 20518848 2430863 We conclude that mediated Rac1 activation is *required* for induction of [TNF-a] expression in cardiomyocytes and cardiac dysfunction during endotoxemia . Positive_regulation TNF PIK3R1 21209364 2402357 While investigating the different actors of signalization , we found that p38 kinase and were playing an important *role* in HKSA phagocytosis and [TNF] production . Positive_regulation TNF PIK3R1 21637390 2437148 Both [TNF-a] and IL-6 production by HBHA was *regulated* by the NF-?B , , and MAPK pathways . Positive_regulation TNF PIK3R1 21836068 2495788 Inhibition of *blocked* the effects of TMD23 on chemotactic motility , matrix metalloproteinase-9 , interleukin-8 , and [TNF-a] . Positive_regulation TNF PIK3R1 23188524 2745418 We found that MAPK and Akt inhibitors , but not inhibitor , remarkably *suppressed* ACPA mediated [TNF-a] production . Positive_regulation TNF PIK3R1 24089494 2848143 We show that trafficking of GABA ( A ) Rs in response to TNFa is mediated by neuronally expressed [TNF] receptor 1 and *requires* activation of p38 MAPK , , protein phosphatase 1 (PP1) , and dynamin GTPase . Positive_regulation TNF PIK3R4 11266376 796726 There has been recent speculation on the *activation* of ( PI 3-kinase ) by [TNF-alpha] and its role in the regulation of genes controlled by NF-kappaB . Positive_regulation TNF PIK3R4 11356844 834405 *Activation* of signaling by [tumor necrosis factor (TNF)] activates IKK and NF-kappaB . Positive_regulation TNF PIK3R4 12606779 1062955 Moreover , signal was *required* for excess [TNF-alpha] production in human macrophages derived from THP-1 cells . Positive_regulation TNF PIK3R4 15722197 1374638 The *activation* of NF-kappaB and by [TNF-alpha] and TRAIL overrides the pro-apoptotic effects of these ligands in carcinoma cells and hinders their therapeutic application . Positive_regulation TNF PIK3R4 23538493 2788582 In addition , [TNF-a] *induced* a downregulation of claudin-1 , claudin-2 , claudin-4 , and occludin as well as activation of signaling in T-84 but not Caco-2 cells , which was reversed by adalimumab . Positive_regulation TNF PIM1 16542375 1537197 Although PIM and LAM also had a significant activity , LAM rather than *stimulated* higher [TNF-alpha] production by alveolar macrophage . Positive_regulation TNF PIM1 23226468 2708171 Overexpression of in THP-1 monocytes *reduced* secretion of IL-1ß and [TNF-a] . Positive_regulation TNF PINK1 2387094 140898 In vitro treatment of control PBMC with the tuberculin *promoted* an increased [TNF-alpha] production which was similar to that of untreated PBMC from tuberculosis patients . Positive_regulation TNF PINK1 6391657 43414 However , , OK 432 , PSK , and Choreito were unable to *induce* [TNF] activity . Positive_regulation TNF PKN1 18435913 1908196 SiRNA of Pkn1 , a Rho-GTPase effecter protein kinase , suppressed TNFalpha levels as well as Pkn1 expression , suggesting that is *involved* in [TNFalpha] signaling . Positive_regulation TNF PLA2G10 18511424 1939494 Our results show that expression *inhibits* macrophage activation and inflammatory responses upon stimulation , characterized by reduced cell adhesion and nitric oxide production , a decrease in [tumor necrosis factor (TNF)] , and an increase in interleukin (IL)-10 . Positive_regulation TNF PLA2G1B 10065947 593534 The study indicates that the synergistic stimulation of prostaglandin production by IL-1beta , and [TNFalpha] is *mediated* partly at the level of COX-2 and partly at the level of and that PKC is involved in the signal transduction of the synergy between the two cytokines . Positive_regulation TNF PLA2G1B 1500203 193631 Since both interleukin 1 and [tumor necrosis factor] *induce* expression of the proinflammatory enzyme , we examined serum PLA2 levels in 14 adults with malaria . Positive_regulation TNF PLA2G1B 1737348 181912 The analysis of TNF alpha-sensitive cells has shown that phospholipase A2 is activated by [TNF alpha] in these cells and that the activity of is *required* for their cytolysis . Positive_regulation TNF PLA2G1B 1737348 181915 These results indicate that a protein synthesis dependent resistance mechanism expressed by these cell lines blocks TNF alpha mediated cytolysis by preventing the *activation* of by [TNF alpha] . Positive_regulation TNF PLA2G1B 1885215 165701 Both IL-1 and [TNF] *induced* the de novo synthesis of in a concentration dependent manner . Positive_regulation TNF PLA2G1B 2156930 129524 We also demonstrate that inhibition of activity with bromophenacyl bromide or quinacrine *blocks* the induction of [TNF] transcripts by LPS . Positive_regulation TNF PLA2G1B 2494431 108022 Moreover , inhibitors of *blocked* both the increase in arachidonic acid release and the induction of [TNF] transcripts . Positive_regulation TNF PLA2G1B 3128274 91754 Tumour necrosis factor ( [cachectin] ) *induces* activity and synthesis of a phospholipase A2-activating protein in endothelial cells . Positive_regulation TNF PLA2G1B 7706741 297820 PLAP , PLAP peptide , and melittin , a bee venom activator with homology with PLAP , all *increased* IL-1 and [TNF] production in a time- and dose dependent manner . Positive_regulation TNF PLA2G1B 7706741 297824 PLAP stimulation of [TNF] and IL-1 could be enhanced with co-treatment of cells with free fatty acids , such as arachidonic or linoleic acid , but it was not *blocked* completely by inhibitors . Positive_regulation TNF PLA2G1B 8040024 266652 Previous work has demonstrated that inhibitors of attenuate ionizing radiation induced arachidonic acid production , protein kinase C activation and *prevent* subsequent induction of the [tumor necrosis factor] gene . Positive_regulation TNF PLA2G1B 8762444 343594 Those results indicated that activation was *involved* in the [TNF] stimulated enhancement of neutrophil chemotaxis and adhesion . Positive_regulation TNF PLA2G2D 15611272 1357375 Both *induced* [TNF-alpha] and IL-6 release in a concentration dependent manner by increasing their mRNA expression . Positive_regulation TNF PLA2G4A 10501211 648484 Signaling mechanisms *involved* in the activation of arachidonic acid metabolism in human astrocytoma cells by [tumor necrosis factor-alpha] : phosphorylation of and transactivation of cyclooxygenase-2 . Positive_regulation TNF PLA2G4A 10913368 716280 *Activation* of ERK1/2 and by the p55 [TNF] receptor occurs independently of FAN . Positive_regulation TNF PLA2G4A 11120795 758219 Western blot analysis revealed that [TNF] *induced* a differential cleavage of in TNF-sensitive vs TNF-resistant cells . Positive_regulation TNF PLA2G4A 11390371 842550 We have previously shown that both secretory and ( PLA(2) ) are *involved* in [TNF-alpha-] and IL-1beta induced NF-kappaB activation . Positive_regulation TNF PLA2G4A 22427514 2594379 H/R and [TNF-a] *induced* phosphorylation in cPLA(2)a ( +/+ ) cardiomyocytes , which was reversible by sTNFR : Fc . Positive_regulation TNF PLA2G4A 24069158 2846946 [TNF-a] *induces* expression in human lung epithelial cells via JNK1/2- and p38 MAPK dependent AP-1 activation . Positive_regulation TNF PLA2G4A 24441870 2922915 [TNF-a] *induces* expression via Jak2/PDGFR dependent Elk-1/p300 activation in human lung epithelial cells . Positive_regulation TNF PLA2G4A 8300750 241000 The E3 14.7K and 10.4K/14.5K proteins inhibit [TNF] *activation* of , which may explain how they inhibit TNF cytolysis . Positive_regulation TNF PLA2G4A 8611631 352990 [Tumor necrosis factor-alpha] *induces* the 85-kDa gene expression in human bronchial epithelial cells . Positive_regulation TNF PLA2G4A 8763993 378261 [TNF] *activation* of the 85-kDa is thought to be essential for TNF cytolysis ( i.e. , TNF induced apoptosis ) . Positive_regulation TNF PLA2G4A 8763993 378262 Here we provide evidence that cPLA2 is important in the response of Ad-infected cells to TNF and that the mechanism by which E3-14.7K and E3-10.4K/14.5K inhibit TNF cytolysis is by inhibiting [TNF] *activation* of . Positive_regulation TNF PLA2G4A 9060638 417777 We now report that [TNF] *induces* translocation of from the cytosol to membranes in Ad-infected human A549 cells and that E3-10.4K/14.5K but not E3-14.7K or E1B-19K is required to inhibit TNF induced translocation of cPLA2 . Positive_regulation TNF PLA2G4A 9637506 513725 *Activation* of by [TNF] has been shown to be an important component of the signaling pathway leading to cell death . Positive_regulation TNF PLAA 3128274 91755 Tumour necrosis factor ( [cachectin] ) *induces* phospholipase A2 activity and synthesis of a in endothelial cells . Positive_regulation TNF PLAA 7706741 297814 *induces* the synthesis of IL-1 and [TNF] in human monocytes . Positive_regulation TNF PLAA 7706741 297818 To further explore the mechanisms found in the inflammatory response , we examined the ability of to *stimulate* release of [TNF] and IL-1 from human peripheral blood monocytes . Positive_regulation TNF PLAA 7706741 297821 PLAP , peptide , and melittin , a bee venom PLA2 activator with homology with PLAP , all *increased* IL-1 and [TNF] production in a time- and dose dependent manner . Positive_regulation TNF PLAT 11487146 845173 The present results suggested that TNF-alpha stimulates PA activity via an enhancement of tPA gene expression in HDP cells and MMP-2 activity , and further that *activated* [TNF-alpha] stimulated MMP-9 . Positive_regulation TNF PLAT 12052248 984314 Overnight stimulation of HUVEC with either LPS or [TNFalpha] , or 30 min *stimulation* with thrombin , phorbol-myristate-acetate , , or angiotensin-II did not cause a significant release of annexin V-binding MP . Positive_regulation TNF PLAT 16171572 1457364 [TNF-alpha] *induced* a time and concentration dependent activation of the urokinase type plasminogen activator ( u-PA ) and activity in A549 cells . Positive_regulation TNF PLAT 21792242 2532310 We present in vitro and in vivo evidence indicating that endogenous and recombinant tPA *induce* the expression of neuronal [tumor necrosis factor-a] . Positive_regulation TNF PLAT 22162045 2549118 Here , we found that is *required* for Aß-mediated microglial inflammatory response and [tumor necrosis factor-a] release . Positive_regulation TNF PLAU 1311745 179048 Immunoreactive was *induced* equally by IFN and [TNF] , but TNF generated higher levels of PAI-2 . Positive_regulation TNF PLAU 15183452 1255971 We also demonstrate that both [TNF-alpha] and VEGF *induce* upregulated expression of ( u-PA ) . Positive_regulation TNF PLAU 16171572 1457365 [TNF-alpha] *induced* a time and concentration dependent activation of the ( u-PA ) and tissue type plasminogen activator (t-PA) activity in A549 cells . Positive_regulation TNF PLAU 1905804 161646 Transcription of the human ( uPA ) gene in HeLa cells is *induced* by phorbol myristate acetate ( PMA ) , interleukin-1 (IL-1) and [tumor necrosis factor alpha (TNF alpha)] . Positive_regulation TNF PLAU 20804741 2341698 [TNF-a] *induces* expression of and ß-catenin activation through generation of ROS in human breast epithelial cells . Positive_regulation TNF PLAU 22166006 2536643 PMA , LPS , and [TNF-alpha] , as well as uPA itself , *induce* expression in lung epithelial cells . Positive_regulation TNF PLAU 22166006 2536645 PMA , LPS , and [TNF-alpha] *induce* uPA expression through increased synthesis as well as stabilization of uPA mRNA , while increases its own expression solely through uPA mRNA stabilization . Positive_regulation TNF PLAU 8547638 346404 Association of [TNF] with the agents *induced* a PAI-1 response that was more than additive of the two , whereas the secretion of was not enhanced . Positive_regulation TNF PLAUR 12908082 1150806 Furthermore , the cells did not express receptors including types I and II TNF-alpha receptors , uPA receptor (uPAR) , C-x-C-chemokine receptor-1 (CXCR-1) , or C-C-chemokine receptor-2 , corresponding to [TNF-alpha] , uPA , IL-8 and MCP-1 , respectively , that were *induced* by doxorubicin in the cells , although SBC-7 cells expressed , and EBC-1 cells expressed CXCR-1 . Positive_regulation TNF PLAUR 8049441 267472 By contrast , [TNF alpha] *induced* a 2.5-fold increase in the level of protein released into conditioned medium ( compared with unstimulated cells ) , whereas IFN gamma had no effect . Positive_regulation TNF PLCB2 19850892 2170176 Selective down-regulation of , but not PLCbeta1 , using small interfering RNA resulted in increased VEGF expression in response to A ( 2A ) R agonists , but did not *suppress* [TNFalpha] expression . Positive_regulation TNF PLCG1 18079103 1874532 Disruption of signalling *attenuates* cardiac [tumor necrosis factor-alpha] expression and improves myocardial function during endotoxemia . Positive_regulation TNF PLCG1 18079103 1874534 The purpose of this study was to investigate the *role* of phosphatidylinositol ( PI ) ( PLCgamma1 ) in cardiac [TNF-alpha] expression , and myocardial dysfunction during endotoxemia . Positive_regulation TNF PLCG1 18079103 1874536 signalling *induces* cardiac [TNF-alpha] expression and myocardial dysfunction during LPS stimulation . Positive_regulation TNF PLCG2 18233961 1864256 Moreover , was *necessary* for the full production of [TNF-alpha] and IL-6 . Positive_regulation TNF PLD1 24548427 2915093 is *required* for lipopolysaccharide induced [tumor necrosis factor-a] expression and production through S6K1/JNK/c-Jun pathway in Raw 264.7 cells . Positive_regulation TNF PLD1 24548427 2915095 The purpose of this study was to identify the *role* of in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression and production . Positive_regulation TNF PLD1 24548427 2915107 To investigate the *role* of in LPS induced [TNF-a] expression and production , we transfected PLD1 and PLD2 siRNAs to Raw 264.7 cells , respectively . Positive_regulation TNF PLD2 24548427 2915108 To investigate the *role* of in LPS induced [TNF-a] expression and production , we transfected PLD1 and PLD2 siRNAs to Raw 264.7 cells , respectively . Positive_regulation TNF PLD3 24548427 2915103 To investigate the *role* of in LPS induced [TNF-a] expression and production , we transfected PLD1 and PLD2 siRNAs to Raw 264.7 cells , respectively . Positive_regulation TNF PLD4 24548427 2915104 To investigate the *role* of in LPS induced [TNF-a] expression and production , we transfected PLD1 and PLD2 siRNAs to Raw 264.7 cells , respectively . Positive_regulation TNF PLD5 24548427 2915105 To investigate the *role* of in LPS induced [TNF-a] expression and production , we transfected PLD1 and PLD2 siRNAs to Raw 264.7 cells , respectively . Positive_regulation TNF PLD6 24548427 2915106 To investigate the *role* of in LPS induced [TNF-a] expression and production , we transfected PLD1 and PLD2 siRNAs to Raw 264.7 cells , respectively . Positive_regulation TNF PLG 14651966 1173617 *induced* IL-1beta and [TNF-alpha] production in microglia is regulated by reactive oxygen species . Positive_regulation TNF PLG 1714936 164919 [TNF] *induced* a brief fourfold increase in the overall plasma activity peaking after 1 h ( p less than 0.0001 ) , which was associated with rises in the antigenic levels of urokinase-type plasminogen activator ( p less than 0.0001 ) and tissue-type plasminogen activator ( p less than 0.0001 ) . Positive_regulation TNF PLG 17395890 1766216 Hirudin , a thrombin inhibitor , and aprotinin , an inhibitor of , *reduced* smoke mediated [TNF-alpha] and MMP-12 release , and A1AT inhibited both plasmin and thrombin activity in a cell-free functional assay . Positive_regulation TNF PLK1 12105863 962920 In vitro , LPS stimulated Kupffer cells to secrete [TNF-alpha] , which *enhanced* PLK activity on the hepatic stellate cell surface through increasing binding , thereby inducing proteolytic activation of latent TGF-beta and its autoinduction . Positive_regulation TNF PLK1 24205328 2864784 is *involved* in toll-like receptor (TLR) mediated [TNF-a] production in monocytic THP-1 cells . Positive_regulation TNF PLK1 24205328 2864792 Moreover , western blot results showed that TLRs activated PLK1 , and inhibition by RNA interference *down-regulated* Pam3CSK4 induced [TNF-a] production , suggesting the involvement of PLK1 in TNF-a up-regulation . Positive_regulation TNF PLN 17913704 1830214 Together with cPLA(2) redistribution and AA release , [TNFalpha] *induced* a time dependent phosphorylation of ERK , MSK1 , PKCzeta , CaMKII , and on the threonine 17 residue . Positive_regulation TNF PLSCR1 17590392 1792430 These results indicate that maximal stimulation of by LPS in liver *required* [TNFalpha] and/or IL-1beta , whereas the stimulation of PLSCR1 in adipose tissue is not dependent on TNFalpha and/or IL-1beta . Positive_regulation TNF PMP2 8975923 408650 Two anti-CD14 monoclonal antibodies ( 60BCA and 3C10 ) inhibited the production of [TNF-alpha] *induced* by . Positive_regulation TNF PMP2 8975923 408652 The results indicate that ( i ) induction of TNF-alpha by C. neoformans and GXMs strongly depends on complement , ( ii ) MP1 and MP2 induction of TNF-alpha is facilitated by a heat-stable serum factor other than Ig , and ( iii ) CD14 may be involved in the *induction* of [TNF-alpha] by . Positive_regulation TNF PMP2 9300722 453888 Recombinant hMBP enhanced [TNF-alpha] *induction* by as well as binding of FITC-MP2 to PBMCs . Positive_regulation TNF PMPCB 17008396 1674093 However , [TNF] *induced* a NFkappaB DNA binding complex in p50 null MEC nuclear extracts . Positive_regulation TNF PMPS 11583705 865780 *induced* interleukin-8 (IL-8) , interleukin-1 beta (IL-1 beta) , and [tumor necrosis factor alpha (TNF alpha)] production by THP-1 . Positive_regulation TNF PMS1 23593410 2773526 Western blot assay indicated that *suppressed* the [TNF-a] induced inhibitor of ?B-a ( I?B-a ) phosphorylation , I?B-a degradation , and p65 phosphorylation . Positive_regulation TNF PMS2 23593410 2773527 Western blot assay indicated that *suppressed* the [TNF-a] induced inhibitor of ?B-a ( I?B-a ) phosphorylation , I?B-a degradation , and p65 phosphorylation . Positive_regulation TNF PNPLA3 19149923 2026724 Plasma levels decreased and plasma [TNF-alpha] levels *increased* in children with obesity and both were main influential factors for % BF in children . Positive_regulation TNF POLD3 18787755 1976070 The low-virulent African swine fever virus ( ) *induces* enhanced expression and production of relevant regulatory cytokines ( IFNalpha , [TNFalpha] and IL12p40 ) on porcine macrophages in comparison to the highly virulent ASFV/L60 . Positive_regulation TNF POLDIP2 10604552 575041 The results showed that [TNF-alpha] *induced* RANTES production and MAP kinase activity in human pulmonary vascular endothelial cells . Positive_regulation TNF POLDIP2 11034403 740722 Although exogenous hsp27 stimulation activated all three monocyte mitogen activated protein kinase pathways ( extracellular signal related kinase ( ERK ) 1/2 , c-Jun N-terminal kinase , and p38 ) , only p38 activation was sustained and required for hsp27 induction of monocyte IL-10 , while both ERK 1/2 and activation were *required* for induction of [TNF-alpha] when using the p38 inhibitor SB203580 or the ERK inhibitor PD98059 . Positive_regulation TNF POLDIP2 11751383 889874 However , [TNF] *activation* of or stress activated protein kinase/c-Jun NH ( 2 ) -terminal kinase is not inhibited by disruption of KSR signaling . Positive_regulation TNF POLDIP2 11920316 926077 The *role* of and extracellular signal regulated kinase ( ERK ) mitogen activated protein (MAP) kinase pathways in the up-regulation of inducible nitric oxide synthase (iNOS) and [tumor necrosis factor (TNF)] production in macrophages stimulated with Streptococcus pneumoniae was examined . Positive_regulation TNF POLDIP2 14566965 1155094 In both prechondrocytes and articular chondrocytes , [TNFalpha] *induced* concentration dependent activation of MEK1/2 and NF-kappaB , but not or JNK . Positive_regulation TNF POLDIP2 15312829 1285293 *regulates* the expression of the cytokines tumor necrosis ( [TNF)-alpha] and interleukin (IL)-1beta , 2 mediators involved in the development of OB in a tracheal transplant model . Positive_regulation TNF POLDIP2 15618191 1357637 The [TNF-alpha] production was *dependent* on both and extracellular signal regulated kinase 1/2 ( ERK 1/2 ) activation . Positive_regulation TNF POLDIP2 16271232 1479198 Similarly , the increased gene expression of proinflammatory cytokines [TNF-alpha] and IL-1beta in gastric mucosa induced by WIR stress were significantly *diminished* by MAPK inhibition . Positive_regulation TNF POLDIP2 16275891 1502462 We examined the pathways that regulate tumor necrosis factor (TNF) mediated MMP-9 release and found this to be dependent on the TNF receptor I . [TNF] rapidly activated extracellular signal regulated kinase and mitogen *activated* protein kinases , but neither of these pathways was critical for MMP-9 release . Positive_regulation TNF POLDIP2 16403817 1540121 The [TNF] + dex stimulated increase in leptin was associated with an increase in p38 MAPK activity and was totally *blocked* by MAPK inhibitors . Positive_regulation TNF POLDIP2 16418769 1495059 [TNFalpha] *induced* and ERK activation , whereas oridonin triggered only ERK activation . Positive_regulation TNF POLDIP2 18042890 1828836 Conversely phosphorylated ( p-p38 ) could *induce* the upregulation of [TNF-alpha] . Positive_regulation TNF POLDIP2 18390808 1925659 We tested the hypothesis that mitogen activated protein kinase activation is *necessary* for [TNF-alpha] production , neutrophil activation , and subsequent liver injury . Positive_regulation TNF POLDIP2 20303596 2230494 Furthermore , inhibitors of and MSK1 , but not PKA , completely *blocked* the production of IL-10 and [TNFalpha] in LPS stimulated macrophages . Positive_regulation TNF POLDIP2 21911466 2491943 By focusing on mitogen activated protein kinases , we show that both extracellular signal regulated kinase 1/2 and , but not JNK , are *required* for hBD- , [TNF-a-] , and IL-1ß induced secretion of CCL20 by HOECs . Positive_regulation TNF POLDIP2 9379049 465839 In this study , we have investigated the mechanism of *activation* of the by [TNF-alpha] in mouse bone marrow derived macrophages . Positive_regulation TNF POLG2 7829967 293473 We present evidence that the [TNF] activities are TNF receptor *mediated* and are not due to insertion of TNF into lipid bilayers , an effect that could be susceptible to DMSO , as this component has been described to modify cell membrane characteristics . Positive_regulation TNF PON1 19034653 2093268 ROS in the colon , the level of interleukin 1 beta (IL-1 beta) in colonic mucosa , serum [tumor necrosis factor] a ( TNF-alpha ) , MPO , and MDA were significantly *increased* in DSS treated animals ( P < 0.01 ) , with decreased activity ( P < 0.01 ) . Positive_regulation TNF POU2F1 11393654 823091 The evidence presented here , therefore , suggests the possibility that could *contribute* to the modulation of [TNFA] expression by means of its allele-specific binding manner . Positive_regulation TNF PPARA 10377130 623615 Utilizing PPARalpha wild-type ( WT ) and knockout ( KO ) mice , we showed that the effect of fenofibrate on LPS induced [TNF] expression was indeed *mediated* by . Positive_regulation TNF PPARA 11782473 916666 In in vivo studies , activators moderately *up-regulated* [TNFalpha] mRNA expression in mouse liver . Positive_regulation TNF PPARA 11856764 914389 When cells were transfected with different constructs of the rat sPLA ( 2 ) -IIA promoter fused to a luciferase reporter gene , a stimulation with [TNF-alpha] in the *presence* of the activators caused an enhanced promoter activity compared with that induced by TNF-alpha alone . Positive_regulation TNF PPARA 19640904 2138165 *reduced* the NF-kappaB induced overexpression of [TNF-alpha] and apoptosis in cultured kidney cells . Positive_regulation TNF PPARD 16698033 1570060 Adenoviral mediated overexpression of substantially *inhibited* [TNFalpha] expression in cultured cardiomyocytes compared to controls , whereas overexpression of a PPARdelta mutant with ablated ligand binding domain did not show similar effect . Positive_regulation TNF PPARG 11159886 781449 Activation of *resulted* in down-regulation of intercellular adhesion molecule 1 expression by intestinal endothelium and tissue [tumor necrosis factor] alpha messenger RNA levels most likely by inhibition of the NF-kappa B pathway . Positive_regulation TNF PPARG 12364456 995187 The aim of this study was to elucidate whether natural [ 15-deoxy-Delta ( 12,14 ) -PGJ ( 2 ) ( 15d-PGJ ( 2 ) ) ] and synthetic ( troglitazone ) ligands *regulate* the secretion of IL-6 , IL-8 , and [TNF-alpha] from human intrauterine tissues . Positive_regulation TNF PPARG 17325208 1706467 In these cells , we observed *dependent* inhibition of nuclear factor-kappaB (NF-kappaB) activation and [TNF-alpha] expression in response to PMA . Positive_regulation TNF PPARG 20404035 2246079 [TNF-alpha] also *induced* Cd36 and peroxisome proliferators activated receptor ( expression , as well as microsomal triglyceride transfer protein ( Mtp ) protein and mRNA , but suppressed the sterol regulatory element binding protein ( Srebp)1c protein and mRNA level . Positive_regulation TNF PPM1A 18930133 2013557 and PPM1B associate with the phosphorylated form of IKKbeta , and the interaction between PPM1A/PPM1B and IKKbeta is *induced* by [TNFalpha] in a transient fashion in the cells . Positive_regulation TNF PPM1B 18930133 2013558 PPM1A and associate with the phosphorylated form of IKKbeta , and the interaction between PPM1A/PPM1B and IKKbeta is *induced* by [TNFalpha] in a transient fashion in the cells . Positive_regulation TNF PPP1R12A 19427347 2106770 [Tumor necrosis factor (TNF)-alpha] stimulated interleukin (IL)-6 release and *induced* the phosphorylation of myosin phosphatase targeting subunit ( , a Rho-kinase substrate . Positive_regulation TNF PPP1R3B 20153259 2248505 Using PBMC from healthy individuals , we show that monocytes differentiated with IL-15 ( IL15-DC ) produced IL-1beta , IL-6 , IL-15 , IL-23 , [TNFalpha] and CCL20 in *response* to and activated contact dependent Th17 and Th1 responses from autologous CD4 ( + ) T cells . Positive_regulation TNF PPP2CA 15618191 1357642 Our studies are the first to demonstrate an important role for the transcription factor CREB in [TNF-alpha] production by mycobacterium infected macrophages , as well as a *role* for M. avium 's induction of phosphatase activity as a mechanism to limit macrophage activation . Positive_regulation TNF PPP2CA 17872368 1823577 [TNF-alpha] did not affect total cell Cx43-PP2A catalytic subunit interaction , but it did *induce* catalytic subunit recruitment to the Triton X-100 insoluble subcellular fraction , in which Cx43-gap junction plaques are recovered . Positive_regulation TNF PPP2CA 18292600 1891529 Endogenous complex can be detected in the resting state , and [TNF] *induces* a complex formation of AIP1-PP2A with ASK1 . Positive_regulation TNF PPP2R1A 15618191 1357643 Our studies are the first to demonstrate an important role for the transcription factor CREB in [TNF-alpha] production by mycobacterium infected macrophages , as well as a *role* for M. avium 's induction of phosphatase activity as a mechanism to limit macrophage activation . Positive_regulation TNF PPP2R1A 17872368 1823578 [TNF-alpha] did not affect total cell Cx43-PP2A catalytic subunit interaction , but it did *induce* catalytic subunit recruitment to the Triton X-100 insoluble subcellular fraction , in which Cx43-gap junction plaques are recovered . Positive_regulation TNF PPP2R1A 18292600 1891530 Endogenous complex can be detected in the resting state , and [TNF] *induces* a complex formation of AIP1-PP2A with ASK1 . Positive_regulation TNF PPP2R2B 15618191 1357644 Our studies are the first to demonstrate an important role for the transcription factor CREB in [TNF-alpha] production by mycobacterium infected macrophages , as well as a *role* for M. avium 's induction of phosphatase activity as a mechanism to limit macrophage activation . Positive_regulation TNF PPP2R2B 17872368 1823579 [TNF-alpha] did not affect total cell Cx43-PP2A catalytic subunit interaction , but it did *induce* catalytic subunit recruitment to the Triton X-100 insoluble subcellular fraction , in which Cx43-gap junction plaques are recovered . Positive_regulation TNF PPP2R2B 18292600 1891531 Endogenous complex can be detected in the resting state , and [TNF] *induces* a complex formation of AIP1-PP2A with ASK1 . Positive_regulation TNF PPP3CA 10913190 716199 Here , we show that extracellular signal regulated kinase ( ERK ) kinase activity but not phosphatase activity is *required* for LPS stimulated [TNF-alpha] gene expression . Positive_regulation TNF PPP3CA 1382293 198229 That CsA inhibited IL-1 beta mRNA accumulation in IgE activated BMMCs with an IC50 similar to that for inhibition of calcineurin activity , whereas the IC50 values were approximately 20-fold higher for the inhibition of TNF-alpha and IL-6 mRNA , suggests that the induction of [TNF-alpha] and IL-6 is less *dependent* upon activity than is the induction of IL-1 beta . Positive_regulation TNF PPP3CA 15005855 1217516 HOS-TE85 cells were treated with Ion/PMA or [TNF-alpha] in the *presence* and absence of , cyclosporin A , and FK506 . Positive_regulation TNF PPP3CA 16380462 1539843 Collectively , these data verify the *role* of and NFAT in CaR mediated [TNF] production by mTAL cells . Positive_regulation TNF PPP3CA 8046352 267027 *mediates* human [tumor necrosis factor] alpha gene induction in stimulated T and B cells . Positive_regulation TNF PPP3CA 8046352 267030 Here we show that phosphatase activity is both *necessary* and sufficient for [TNF-alpha] gene transcription in T cells , and identify the factor that binds to the kappa 3 element of the TNF-alpha gene promoter as the target for calcineurin action . Positive_regulation TNF PPP3CA 9973478 596195 Calcium dependent *activation* of [TNF] family gene expression by Ca2+/calmodulin kinase type IV/Gr and . Positive_regulation TNF PPP3CB 10913190 716200 Here , we show that extracellular signal regulated kinase ( ERK ) kinase activity but not phosphatase activity is *required* for LPS stimulated [TNF-alpha] gene expression . Positive_regulation TNF PPP3CB 1382293 198230 That CsA inhibited IL-1 beta mRNA accumulation in IgE activated BMMCs with an IC50 similar to that for inhibition of calcineurin activity , whereas the IC50 values were approximately 20-fold higher for the inhibition of TNF-alpha and IL-6 mRNA , suggests that the induction of [TNF-alpha] and IL-6 is less *dependent* upon activity than is the induction of IL-1 beta . Positive_regulation TNF PPP3CB 15005855 1217517 HOS-TE85 cells were treated with Ion/PMA or [TNF-alpha] in the *presence* and absence of , cyclosporin A , and FK506 . Positive_regulation TNF PPP3CB 16380462 1539844 Collectively , these data verify the *role* of and NFAT in CaR mediated [TNF] production by mTAL cells . Positive_regulation TNF PPP3CB 8046352 267028 *mediates* human [tumor necrosis factor] alpha gene induction in stimulated T and B cells . Positive_regulation TNF PPP3CB 8046352 267031 Here we show that phosphatase activity is both *necessary* and sufficient for [TNF-alpha] gene transcription in T cells , and identify the factor that binds to the kappa 3 element of the TNF-alpha gene promoter as the target for calcineurin action . Positive_regulation TNF PPP3CB 9973478 596196 Calcium dependent *activation* of [TNF] family gene expression by Ca2+/calmodulin kinase type IV/Gr and . Positive_regulation TNF PPP3CC 10913190 716201 Here , we show that extracellular signal regulated kinase ( ERK ) kinase activity but not phosphatase activity is *required* for LPS stimulated [TNF-alpha] gene expression . Positive_regulation TNF PPP3CC 1382293 198231 That CsA inhibited IL-1 beta mRNA accumulation in IgE activated BMMCs with an IC50 similar to that for inhibition of calcineurin activity , whereas the IC50 values were approximately 20-fold higher for the inhibition of TNF-alpha and IL-6 mRNA , suggests that the induction of [TNF-alpha] and IL-6 is less *dependent* upon activity than is the induction of IL-1 beta . Positive_regulation TNF PPP3CC 15005855 1217518 HOS-TE85 cells were treated with Ion/PMA or [TNF-alpha] in the *presence* and absence of , cyclosporin A , and FK506 . Positive_regulation TNF PPP3CC 16380462 1539845 Collectively , these data verify the *role* of and NFAT in CaR mediated [TNF] production by mTAL cells . Positive_regulation TNF PPP3CC 8046352 267029 *mediates* human [tumor necrosis factor] alpha gene induction in stimulated T and B cells . Positive_regulation TNF PPP3CC 8046352 267032 Here we show that phosphatase activity is both *necessary* and sufficient for [TNF-alpha] gene transcription in T cells , and identify the factor that binds to the kappa 3 element of the TNF-alpha gene promoter as the target for calcineurin action . Positive_regulation TNF PPP3CC 9973478 596197 Calcium dependent *activation* of [TNF] family gene expression by Ca2+/calmodulin kinase type IV/Gr and . Positive_regulation TNF PPP5C 17023568 1674273 *had* the same effects as 17beta-estradiol on IL-6 and [TNF-alpha] production by Kupffer cells and SMPhi , and DPN had the same effects on AMPhi and PBMC . Positive_regulation TNF PPP5C 18068095 1846969 also *induced* [tumor necrosis factor (TNF)-alpha] , IL-10 , IL-12 , and interferon (IFN)-gamma in PBMC . Positive_regulation TNF PPP5C 8592105 341980 [TNF-alpha] dose-dependently *induces* SP , an induction that is secondary to an increase in the SP precursor , , mRNA . Positive_regulation TNF PPT1 19345705 2094378 modulates [tumor necrosis factor] alpha *induced* apoptosis . Positive_regulation TNF PRDX2 17499201 1739931 NP *induced* [TNF-alpha] only while induced IL-6 , IL-10 and TNF-alpha . Positive_regulation TNF PRDX2 17626110 1816008 In the presence or absence of dexamethasone , *enhanced* overventilation induced induction of [TNF] and MIP-2alpha , but decreased that of IL-6 , indicating that the effects of HDAC are gene dependent . Positive_regulation TNF PRDX2 25076912 2953959 [TNF] *induced* overall increase in total LTCC expression while stimulated a dual effect : causing induction of LTCC exon 8 expression but repressing expression of other LTCC splice variants including that encoding exons 30 , 31 , 33 , and 34 , exons 30-34 and exons 40-43 . Positive_regulation TNF PRDX2 25097261 2954243 Consistent with being part of an inflammatory cascade , we find that then *induces* [TNF-a] release . Positive_regulation TNF PRKAA1 19853624 2196664 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( IL-1 beta , [TNF-alpha] ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Positive_regulation TNF PRKAA1 20421294 2274479 although inhibiting by short hairpin RNA knock-down or dominant negative alpha1AMPK ( DN-alpha1 ) *increases* LPS- and FFA induced [tumor necrosis factor] alpha expression . Positive_regulation TNF PRKAA2 19853624 2196665 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( IL-1 beta , [TNF-alpha] ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Positive_regulation TNF PRKAA2 20421294 2274480 although inhibiting by short hairpin RNA knock-down or dominant negative alpha1AMPK ( DN-alpha1 ) *increases* LPS- and FFA induced [tumor necrosis factor] alpha expression . Positive_regulation TNF PRKAB1 19853624 2196666 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( IL-1 beta , [TNF-alpha] ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Positive_regulation TNF PRKAB1 20421294 2274481 although inhibiting by short hairpin RNA knock-down or dominant negative alpha1AMPK ( DN-alpha1 ) *increases* LPS- and FFA induced [tumor necrosis factor] alpha expression . Positive_regulation TNF PRKAB2 19853624 2196667 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( IL-1 beta , [TNF-alpha] ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Positive_regulation TNF PRKAB2 20421294 2274482 although inhibiting by short hairpin RNA knock-down or dominant negative alpha1AMPK ( DN-alpha1 ) *increases* LPS- and FFA induced [tumor necrosis factor] alpha expression . Positive_regulation TNF PRKACB 11675405 873335 However , inhibition of MAPK ( p42/p44 ) and [TNF-alpha] promoter activity was partially *prevented* by the inhibitors , H-89 ( 5 x 10 ( -6 ) M ) and KT5720 ( 10 ( -5 ) M ) , whereas the suppression of p38 MAPK or NF-kappa B ( p50 ) was not blocked by these inhibitors . Positive_regulation TNF PRKACB 16438946 1495436 Although gAd partially increased cAMP concentration and activity , it directly reduced leptin induced ERK1/2 and p38 MAPK phosphorylation thus *inhibiting* [TNF-alpha] production . Positive_regulation TNF PRKACB 2549168 117413 As activation of PKA does not slow down the degradation rate of TNF-Rs , but rather enhances protein synthesis dependent reexpression of TNF-Rs after transient PKC mediated transmodulation and after tryptic digestion of TNF-Rs , it is concluded that *stimulates* [TNF-R] synthesis . Positive_regulation TNF PRKACB 2549168 117419 *mediated* enhancement of [TNF-R] expression was predominantly observed in normal peripheral blood monocytes and tumor cell lines of myeloid origin . Positive_regulation TNF PRKACB 7678355 209890 The [TNF-alpha-] and PMA stimulated VCAM-1 expression is *inhibited* by the PKC and inhibitor staurosporine (STS) . Positive_regulation TNF PRKACG 11675405 873336 However , inhibition of MAPK ( p42/p44 ) and [TNF-alpha] promoter activity was partially *prevented* by the inhibitors , H-89 ( 5 x 10 ( -6 ) M ) and KT5720 ( 10 ( -5 ) M ) , whereas the suppression of p38 MAPK or NF-kappa B ( p50 ) was not blocked by these inhibitors . Positive_regulation TNF PRKACG 16438946 1495437 Although gAd partially increased cAMP concentration and activity , it directly reduced leptin induced ERK1/2 and p38 MAPK phosphorylation thus *inhibiting* [TNF-alpha] production . Positive_regulation TNF PRKACG 2549168 117414 As activation of PKA does not slow down the degradation rate of TNF-Rs , but rather enhances protein synthesis dependent reexpression of TNF-Rs after transient PKC mediated transmodulation and after tryptic digestion of TNF-Rs , it is concluded that *stimulates* [TNF-R] synthesis . Positive_regulation TNF PRKACG 2549168 117420 *mediated* enhancement of [TNF-R] expression was predominantly observed in normal peripheral blood monocytes and tumor cell lines of myeloid origin . Positive_regulation TNF PRKACG 7678355 209891 The [TNF-alpha-] and PMA stimulated VCAM-1 expression is *inhibited* by the PKC and inhibitor staurosporine (STS) . Positive_regulation TNF PRKAG1 19853624 2196668 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( IL-1 beta , [TNF-alpha] ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Positive_regulation TNF PRKAG1 20421294 2274483 although inhibiting by short hairpin RNA knock-down or dominant negative alpha1AMPK ( DN-alpha1 ) *increases* LPS- and FFA induced [tumor necrosis factor] alpha expression . Positive_regulation TNF PRKAG2 19853624 2196669 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( IL-1 beta , [TNF-alpha] ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Positive_regulation TNF PRKAG2 20421294 2274484 although inhibiting by short hairpin RNA knock-down or dominant negative alpha1AMPK ( DN-alpha1 ) *increases* LPS- and FFA induced [tumor necrosis factor] alpha expression . Positive_regulation TNF PRKAR1A 11675405 873337 However , inhibition of MAPK ( p42/p44 ) and [TNF-alpha] promoter activity was partially *prevented* by the inhibitors , H-89 ( 5 x 10 ( -6 ) M ) and KT5720 ( 10 ( -5 ) M ) , whereas the suppression of p38 MAPK or NF-kappa B ( p50 ) was not blocked by these inhibitors . Positive_regulation TNF PRKAR1A 16438946 1495438 Although gAd partially increased cAMP concentration and activity , it directly reduced leptin induced ERK1/2 and p38 MAPK phosphorylation thus *inhibiting* [TNF-alpha] production . Positive_regulation TNF PRKAR1A 2549168 117415 As activation of PKA does not slow down the degradation rate of TNF-Rs , but rather enhances protein synthesis dependent reexpression of TNF-Rs after transient PKC mediated transmodulation and after tryptic digestion of TNF-Rs , it is concluded that *stimulates* [TNF-R] synthesis . Positive_regulation TNF PRKAR1A 2549168 117421 mediated *enhancement* of [TNF-R] expression was predominantly observed in normal peripheral blood monocytes and tumor cell lines of myeloid origin . Positive_regulation TNF PRKAR1A 7678355 209892 The [TNF-alpha-] and PMA stimulated VCAM-1 expression is *inhibited* by the PKC and inhibitor staurosporine (STS) . Positive_regulation TNF PRKAR1B 11675405 873338 However , inhibition of MAPK ( p42/p44 ) and [TNF-alpha] promoter activity was partially *prevented* by the inhibitors , H-89 ( 5 x 10 ( -6 ) M ) and KT5720 ( 10 ( -5 ) M ) , whereas the suppression of p38 MAPK or NF-kappa B ( p50 ) was not blocked by these inhibitors . Positive_regulation TNF PRKAR1B 16438946 1495439 Although gAd partially increased cAMP concentration and activity , it directly reduced leptin induced ERK1/2 and p38 MAPK phosphorylation thus *inhibiting* [TNF-alpha] production . Positive_regulation TNF PRKAR1B 2549168 117416 As activation of PKA does not slow down the degradation rate of TNF-Rs , but rather enhances protein synthesis dependent reexpression of TNF-Rs after transient PKC mediated transmodulation and after tryptic digestion of TNF-Rs , it is concluded that *stimulates* [TNF-R] synthesis . Positive_regulation TNF PRKAR1B 2549168 117422 *mediated* enhancement of [TNF-R] expression was predominantly observed in normal peripheral blood monocytes and tumor cell lines of myeloid origin . Positive_regulation TNF PRKAR1B 7678355 209893 The [TNF-alpha-] and PMA stimulated VCAM-1 expression is *inhibited* by the PKC and inhibitor staurosporine (STS) . Positive_regulation TNF PRKAR2A 11675405 873339 However , inhibition of MAPK ( p42/p44 ) and [TNF-alpha] promoter activity was partially *prevented* by the inhibitors , H-89 ( 5 x 10 ( -6 ) M ) and KT5720 ( 10 ( -5 ) M ) , whereas the suppression of p38 MAPK or NF-kappa B ( p50 ) was not blocked by these inhibitors . Positive_regulation TNF PRKAR2A 16438946 1495440 Although gAd partially increased cAMP concentration and activity , it directly reduced leptin induced ERK1/2 and p38 MAPK phosphorylation thus *inhibiting* [TNF-alpha] production . Positive_regulation TNF PRKAR2A 2549168 117417 As activation of PKA does not slow down the degradation rate of TNF-Rs , but rather enhances protein synthesis dependent reexpression of TNF-Rs after transient PKC mediated transmodulation and after tryptic digestion of TNF-Rs , it is concluded that *stimulates* [TNF-R] synthesis . Positive_regulation TNF PRKAR2A 2549168 117423 mediated *enhancement* of [TNF-R] expression was predominantly observed in normal peripheral blood monocytes and tumor cell lines of myeloid origin . Positive_regulation TNF PRKAR2A 7678355 209894 The [TNF-alpha-] and PMA stimulated VCAM-1 expression is *inhibited* by the PKC and inhibitor staurosporine (STS) . Positive_regulation TNF PRKAR2B 11675405 873340 However , inhibition of MAPK ( p42/p44 ) and [TNF-alpha] promoter activity was partially *prevented* by the inhibitors , H-89 ( 5 x 10 ( -6 ) M ) and KT5720 ( 10 ( -5 ) M ) , whereas the suppression of p38 MAPK or NF-kappa B ( p50 ) was not blocked by these inhibitors . Positive_regulation TNF PRKAR2B 16438946 1495441 Although gAd partially increased cAMP concentration and activity , it directly reduced leptin induced ERK1/2 and p38 MAPK phosphorylation thus *inhibiting* [TNF-alpha] production . Positive_regulation TNF PRKAR2B 2549168 117418 As activation of PKA does not slow down the degradation rate of TNF-Rs , but rather enhances protein synthesis dependent reexpression of TNF-Rs after transient PKC mediated transmodulation and after tryptic digestion of TNF-Rs , it is concluded that *stimulates* [TNF-R] synthesis . Positive_regulation TNF PRKAR2B 2549168 117424 *mediated* enhancement of [TNF-R] expression was predominantly observed in normal peripheral blood monocytes and tumor cell lines of myeloid origin . Positive_regulation TNF PRKAR2B 7678355 209895 The [TNF-alpha-] and PMA stimulated VCAM-1 expression is *inhibited* by the PKC and inhibitor staurosporine (STS) . Positive_regulation TNF PRKCA 11478844 842088 PTH , [tumor necrosis factor-alpha (TNF-alpha)] , and interleukin-1 beta (IL-1 beta) *induced* translocation of and -beta ( I ) to the plasma membrane in UMR-106 cells within 5 min . Positive_regulation TNF PRKCA 12385023 1025335 Inhibition of LPS induced PKC activity using pseudosubstrate peptides specific for PKC isoforms established that PKC epsilon but not was *involved* in the production of IL-12 and [TNF-alpha] . Positive_regulation TNF PRKCA 15499968 1326848 In summary , we hereby demonstrate that the FB1 activation of NF-kappaB and sequential induction of [TNFalpha] expression resulting in the subsequent increase in caspase 3 activity are all *dependent* on stimulation in LLC-PK1 cells . Positive_regulation TNF PRKCA 17555806 1773837 Inhibition of and PKCepsilon *reduced* dust induced [TNF-alpha] secretion . Positive_regulation TNF PRKCB 11478844 842089 PTH , [tumor necrosis factor-alpha (TNF-alpha)] , and interleukin-1 beta (IL-1 beta) *induced* translocation of ( I ) to the plasma membrane in UMR-106 cells within 5 min . Positive_regulation TNF PRKCB 12385023 1025336 Inhibition of LPS induced PKC activity using pseudosubstrate peptides specific for PKC isoforms established that PKC epsilon but not was *involved* in the production of IL-12 and [TNF-alpha] . Positive_regulation TNF PRKCB 17584970 1779121 High glucose ( HG ) -induced [TNF-alpha] release was specifically *inhibited* by protein kinase C (PKC)-delta inhibitor ( Rottlerin ; EMD Biosciences , San Diego , CA ) , but not inhibitor ( CGP53353 ; Positive_regulation TNF PRKCD 17584970 1779122 High glucose ( HG ) -induced [TNF-alpha] release was specifically *inhibited* by inhibitor ( Rottlerin ; EMD Biosciences , San Diego , CA ) , but not PKC-beta2 inhibitor ( CGP53353 ; Positive_regulation TNF PRKDC 9636658 513390 The *role* of , a protein kinase involved in the response to DNA damage , in the activation of NF kappa B by IR and [TNF alpha] was examined . Positive_regulation TNF PRL 10404396 629266 We have recently shown that whereas ethanol does not inhibit PRL receptor binding , it markedly inhibits *induced* mitogenesis and [TNF alpha] secretion in cultured astrocytes . Positive_regulation TNF PRL 10760953 683680 Further , we found that PRL induced ICAM-1 expression was , at least in part , due to a *induced* increase in [TNF-alpha] syntheses and secretion . Positive_regulation TNF PRL 12577310 1058177 These observations correlate with in vivo conditions , where *increases* the release of [TNF-alpha] by testicular interstitial macrophages , which , in turn , decreases the human chorionic gonadotropin stimulated release of testosterone by Leydig cells . Positive_regulation TNF PRL 15157954 1250623 The following changes reached significance ( p < .05 ) : ( versus prolactin antibody ) *increased* [tumor necrosis factor-alpha (TNF-alpha)] and interferon-gamma (IFN-gamma) producing CD4+ and CD8+ cells and interleukin-2 (IL-2) producing CD8+ cells . Positive_regulation TNF PRL 16846842 1588083 In addition , *increased* the expressions of IL-6 , IL-10 , IL-12 and [TNF-alpha] in SDCs . Positive_regulation TNF PRL 17336385 1726616 or GH *induced* [TNF-alpha] production by murine macrophages was insensitive in the presence of competitive inhibitor of NOS , L-NMMA . Positive_regulation TNF PRL 18187558 1870144 We have previously reported that *induces* the production of nitric oxide ( NO ) and [tumor necrosis factor (TNF)-alpha] in murine peritoneal macrophages . Positive_regulation TNF PRL 18187558 1870158 Further , pre-treatment of macrophages with SP600125 inhibited the *induced* production of IFN-gamma and [TNF-alpha] . Positive_regulation TNF PRL 23850676 2825122 that PRL directly induces hepatocyte injury and death as evidenced by increased release of lactate dehydrogenase , FASL and [TNF-a] from hepatocytes in the *presence* of ; Positive_regulation TNF PRL 7758825 307617 *induced* expression of glial fibrillary acidic protein and [tumor necrosis factor-alpha] at a wound site in the rat brain . Positive_regulation TNF PRL 7758825 307623 To confirm the *induced* increase in [TNF-alpha] levels , TNF-alpha levels in hypothalamic extracts were measured by bioassay . Positive_regulation TNF PRL 7759566 307802 *induced* expression of interleukin-1 alpha , [tumor necrosis factor-alpha] , and transforming growth factor-alpha in cultured astrocytes . Positive_regulation TNF PRL 8532376 336994 These data suggest that can *regulate* in vivo endogenous [TNF-alpha] production in the cytokine cascade . Positive_regulation TNF PRL 9048591 416795 The aim of this study was to examine the effects of ethanol on *induced* mitogenesis and [TNF alpha] expression in cultured rat astrocytes . Positive_regulation TNF PRL 9048591 416796 PAE during the last 5 days of gestation blunted the *induced* increase in [ 3H ] thymidine incorporation and [TNF alpha] levels in cells grown in the absence of ethanol in the culture medium . Positive_regulation TNF PRL 9048591 416797 Addition of ethanol to primary PAE astrocyte cultures resulted in a modest increase in basal [ 3H ] thymidine incorporation , but completely blocked the *induced* increase in [ 3H ] thymidine incorporation and [TNF alpha] levels . Positive_regulation TNF PRL 9048591 416798 Together , these data indicate that ethanol blocks *induced* mitogenesis and the expression of [TNF alpha] in cultured rat astrocytes and are consistent with the possible inhibition of the astrocytic response by ethanol in vivo . Positive_regulation TNF PRL 9916010 587450 TNFalpha significantly inhibited *induced* StAR and LHR mRNA expression at 1 and 3 h [post-TNFalpha] . Positive_regulation TNF PRM1 10330036 614027 In an effort to elucidate the mechanism of gene inactivation , we report in this study that cationic ( LPD ) complexes , but not each component alone , can *induce* a high level of cytokine production , including interferon-gamma and [tumor necrosis factor-alpha] . Positive_regulation TNF PRM2 10330036 614028 In an effort to elucidate the mechanism of gene inactivation , we report in this study that cationic ( LPD ) complexes , but not each component alone , can *induce* a high level of cytokine production , including interferon-gamma and [tumor necrosis factor-alpha] . Positive_regulation TNF PRM3 10330036 614026 In an effort to elucidate the mechanism of gene inactivation , we report in this study that cationic ( LPD ) complexes , but not each component alone , can *induce* a high level of cytokine production , including interferon-gamma and [tumor necrosis factor-alpha] . Positive_regulation TNF PRMT5 19372584 2058989 *had* no effect on [TNF-alpha] mediated NF-kappaB signaling . Positive_regulation TNF PRNP 11316802 827078 ( 106 -- 126 ) *caused* the release of [TNF-alpha] as detected by enzyme linked immunosorbent assay , and a blocking antibody , anti-TNF-alpha , abolished NOS-II induction elicited by this peptide . Positive_regulation TNF PRNP 11792368 901853 Since microglial COX-2 expression and PGE ( 2 ) synthesis are increased in human and experimental prion diseases , we investigated the effects of the NSAIDs indomethacin and BF389 , an experimental COX-2 selective inhibitor , on the *induced* microglial IL-6 and [TNF-alpha] synthesis in vitro . Positive_regulation TNF PRNP 15837583 1397886 *induced* microglial IL-6 and [TNF-alpha] release significantly increased in the presence of SAP and C1q . Positive_regulation TNF PRNP 16011481 1459386 [TNFalpha] *induces* the expression and recombinant promoter activities of GCLC , GCLM and in H4IIE cells . Positive_regulation TNF PRNP 19457070 2107231 We established that in 1C11 derived neuronal cells antibody mediated ( C ) ligation *triggered* [tumor necrosis factor (TNF)-alpha] release , through recruitment of the metalloproteinase TNF-alpha converting enzyme (TACE) . Positive_regulation TNF PROCR 19620400 2137538 Endothelial NF-kappaB blockade prevented LPS down-regulation of and thrombomodulin protein expressions , *inhibited* tissue [tumor necrosis factor-alpha] converting enzyme activity , reduced EPCR shedding , and restored plasma protein C level . Positive_regulation TNF PRR11 17584736 1779050 The JNK and p38 MAPK groups are major PRR effectors and are key to the *dependent* induction and release of proinflammatory cytokines such as [tumor necrosis factor] and interleukin-8 . Positive_regulation TNF PRR11 23319541 2742387 Finally , activation in SHR neuronal cultures by prorenin activated nuclear factor-?B and *increased* mRNA levels of interleukin-1ß ( 250-fold ) , [tumor necrosis factor-a] ( 32-fold ) , interleukin-6 ( 35-fold ) , C-C motif ligand 5 ( 12-fold ) , and interleukin-10 ( 7-fold ) in a nuclear factor-?B dependent but angiotensin II type 1 receptor independent manner . Positive_regulation TNF PRR12 17584736 1779056 The JNK and p38 MAPK groups are major PRR effectors and are key to the *dependent* induction and release of proinflammatory cytokines such as [tumor necrosis factor] and interleukin-8 . Positive_regulation TNF PRR12 23319541 2742393 Finally , activation in SHR neuronal cultures by prorenin activated nuclear factor-?B and *increased* mRNA levels of interleukin-1ß ( 250-fold ) , [tumor necrosis factor-a] ( 32-fold ) , interleukin-6 ( 35-fold ) , C-C motif ligand 5 ( 12-fold ) , and interleukin-10 ( 7-fold ) in a nuclear factor-?B dependent but angiotensin II type 1 receptor independent manner . Positive_regulation TNF PRR13 17584736 1779049 The JNK and p38 MAPK groups are major PRR effectors and are key to the *dependent* induction and release of proinflammatory cytokines such as [tumor necrosis factor] and interleukin-8 . Positive_regulation TNF PRR13 23319541 2742386 Finally , activation in SHR neuronal cultures by prorenin activated nuclear factor-?B and *increased* mRNA levels of interleukin-1ß ( 250-fold ) , [tumor necrosis factor-a] ( 32-fold ) , interleukin-6 ( 35-fold ) , C-C motif ligand 5 ( 12-fold ) , and interleukin-10 ( 7-fold ) in a nuclear factor-?B dependent but angiotensin II type 1 receptor independent manner . Positive_regulation TNF PRR14 17584736 1779054 The JNK and p38 MAPK groups are major PRR effectors and are key to the *dependent* induction and release of proinflammatory cytokines such as [tumor necrosis factor] and interleukin-8 . Positive_regulation TNF PRR14 23319541 2742391 Finally , activation in SHR neuronal cultures by prorenin activated nuclear factor-?B and *increased* mRNA levels of interleukin-1ß ( 250-fold ) , [tumor necrosis factor-a] ( 32-fold ) , interleukin-6 ( 35-fold ) , C-C motif ligand 5 ( 12-fold ) , and interleukin-10 ( 7-fold ) in a nuclear factor-?B dependent but angiotensin II type 1 receptor independent manner . Positive_regulation TNF PRR15 17584736 1779048 The JNK and p38 MAPK groups are major PRR effectors and are key to the *dependent* induction and release of proinflammatory cytokines such as [tumor necrosis factor] and interleukin-8 . Positive_regulation TNF PRR15 23319541 2742385 Finally , activation in SHR neuronal cultures by prorenin activated nuclear factor-?B and *increased* mRNA levels of interleukin-1ß ( 250-fold ) , [tumor necrosis factor-a] ( 32-fold ) , interleukin-6 ( 35-fold ) , C-C motif ligand 5 ( 12-fold ) , and interleukin-10 ( 7-fold ) in a nuclear factor-?B dependent but angiotensin II type 1 receptor independent manner . Positive_regulation TNF PRR16 17584736 1779057 The JNK and p38 MAPK groups are major PRR effectors and are key to the *dependent* induction and release of proinflammatory cytokines such as [tumor necrosis factor] and interleukin-8 . Positive_regulation TNF PRR16 23319541 2742394 Finally , activation in SHR neuronal cultures by prorenin activated nuclear factor-?B and *increased* mRNA levels of interleukin-1ß ( 250-fold ) , [tumor necrosis factor-a] ( 32-fold ) , interleukin-6 ( 35-fold ) , C-C motif ligand 5 ( 12-fold ) , and interleukin-10 ( 7-fold ) in a nuclear factor-?B dependent but angiotensin II type 1 receptor independent manner . Positive_regulation TNF PRR18 17584736 1779055 The JNK and p38 MAPK groups are major PRR effectors and are key to the *dependent* induction and release of proinflammatory cytokines such as [tumor necrosis factor] and interleukin-8 . Positive_regulation TNF PRR18 23319541 2742392 Finally , activation in SHR neuronal cultures by prorenin activated nuclear factor-?B and *increased* mRNA levels of interleukin-1ß ( 250-fold ) , [tumor necrosis factor-a] ( 32-fold ) , interleukin-6 ( 35-fold ) , C-C motif ligand 5 ( 12-fold ) , and interleukin-10 ( 7-fold ) in a nuclear factor-?B dependent but angiotensin II type 1 receptor independent manner . Positive_regulation TNF PRR19 17584736 1779061 The JNK and p38 MAPK groups are major PRR effectors and are key to the *dependent* induction and release of proinflammatory cytokines such as [tumor necrosis factor] and interleukin-8 . Positive_regulation TNF PRR19 23319541 2742398 Finally , activation in SHR neuronal cultures by prorenin activated nuclear factor-?B and *increased* mRNA levels of interleukin-1ß ( 250-fold ) , [tumor necrosis factor-a] ( 32-fold ) , interleukin-6 ( 35-fold ) , C-C motif ligand 5 ( 12-fold ) , and interleukin-10 ( 7-fold ) in a nuclear factor-?B dependent but angiotensin II type 1 receptor independent manner . Positive_regulation TNF PRR21 17584736 1779062 The JNK and p38 MAPK groups are major PRR effectors and are key to the *dependent* induction and release of proinflammatory cytokines such as [tumor necrosis factor] and interleukin-8 . Positive_regulation TNF PRR21 23319541 2742399 Finally , activation in SHR neuronal cultures by prorenin activated nuclear factor-?B and *increased* mRNA levels of interleukin-1ß ( 250-fold ) , [tumor necrosis factor-a] ( 32-fold ) , interleukin-6 ( 35-fold ) , C-C motif ligand 5 ( 12-fold ) , and interleukin-10 ( 7-fold ) in a nuclear factor-?B dependent but angiotensin II type 1 receptor independent manner . Positive_regulation TNF PRR22 17584736 1779053 The JNK and p38 MAPK groups are major PRR effectors and are key to the *dependent* induction and release of proinflammatory cytokines such as [tumor necrosis factor] and interleukin-8 . Positive_regulation TNF PRR22 23319541 2742390 Finally , activation in SHR neuronal cultures by prorenin activated nuclear factor-?B and *increased* mRNA levels of interleukin-1ß ( 250-fold ) , [tumor necrosis factor-a] ( 32-fold ) , interleukin-6 ( 35-fold ) , C-C motif ligand 5 ( 12-fold ) , and interleukin-10 ( 7-fold ) in a nuclear factor-?B dependent but angiotensin II type 1 receptor independent manner . Positive_regulation TNF PRR24 17584736 1779051 The JNK and p38 MAPK groups are major PRR effectors and are key to the *dependent* induction and release of proinflammatory cytokines such as [tumor necrosis factor] and interleukin-8 . Positive_regulation TNF PRR24 23319541 2742388 Finally , activation in SHR neuronal cultures by prorenin activated nuclear factor-?B and *increased* mRNA levels of interleukin-1ß ( 250-fold ) , [tumor necrosis factor-a] ( 32-fold ) , interleukin-6 ( 35-fold ) , C-C motif ligand 5 ( 12-fold ) , and interleukin-10 ( 7-fold ) in a nuclear factor-?B dependent but angiotensin II type 1 receptor independent manner . Positive_regulation TNF PRR25 17584736 1779063 The JNK and p38 MAPK groups are major PRR effectors and are key to the *dependent* induction and release of proinflammatory cytokines such as [tumor necrosis factor] and interleukin-8 . Positive_regulation TNF PRR25 23319541 2742400 Finally , activation in SHR neuronal cultures by prorenin activated nuclear factor-?B and *increased* mRNA levels of interleukin-1ß ( 250-fold ) , [tumor necrosis factor-a] ( 32-fold ) , interleukin-6 ( 35-fold ) , C-C motif ligand 5 ( 12-fold ) , and interleukin-10 ( 7-fold ) in a nuclear factor-?B dependent but angiotensin II type 1 receptor independent manner . Positive_regulation TNF PRR26 17584736 1779058 The JNK and p38 MAPK groups are major PRR effectors and are key to the *dependent* induction and release of proinflammatory cytokines such as [tumor necrosis factor] and interleukin-8 . Positive_regulation TNF PRR26 23319541 2742395 Finally , activation in SHR neuronal cultures by prorenin activated nuclear factor-?B and *increased* mRNA levels of interleukin-1ß ( 250-fold ) , [tumor necrosis factor-a] ( 32-fold ) , interleukin-6 ( 35-fold ) , C-C motif ligand 5 ( 12-fold ) , and interleukin-10 ( 7-fold ) in a nuclear factor-?B dependent but angiotensin II type 1 receptor independent manner . Positive_regulation TNF PRR3 17584736 1779047 The JNK and p38 MAPK groups are major PRR effectors and are key to the *dependent* induction and release of proinflammatory cytokines such as [tumor necrosis factor] and interleukin-8 . Positive_regulation TNF PRR3 23319541 2742384 Finally , activation in SHR neuronal cultures by prorenin activated nuclear factor-?B and *increased* mRNA levels of interleukin-1ß ( 250-fold ) , [tumor necrosis factor-a] ( 32-fold ) , interleukin-6 ( 35-fold ) , C-C motif ligand 5 ( 12-fold ) , and interleukin-10 ( 7-fold ) in a nuclear factor-?B dependent but angiotensin II type 1 receptor independent manner . Positive_regulation TNF PRR4 17584736 1779046 The JNK and p38 MAPK groups are major PRR effectors and are key to the *dependent* induction and release of proinflammatory cytokines such as [tumor necrosis factor] and interleukin-8 . Positive_regulation TNF PRR4 23319541 2742383 Finally , activation in SHR neuronal cultures by prorenin activated nuclear factor-?B and *increased* mRNA levels of interleukin-1ß ( 250-fold ) , [tumor necrosis factor-a] ( 32-fold ) , interleukin-6 ( 35-fold ) , C-C motif ligand 5 ( 12-fold ) , and interleukin-10 ( 7-fold ) in a nuclear factor-?B dependent but angiotensin II type 1 receptor independent manner . Positive_regulation TNF PRR5 17584736 1779059 The JNK and p38 MAPK groups are major PRR effectors and are key to the *dependent* induction and release of proinflammatory cytokines such as [tumor necrosis factor] and interleukin-8 . Positive_regulation TNF PRR5 23319541 2742396 Finally , activation in SHR neuronal cultures by prorenin activated nuclear factor-?B and *increased* mRNA levels of interleukin-1ß ( 250-fold ) , [tumor necrosis factor-a] ( 32-fold ) , interleukin-6 ( 35-fold ) , C-C motif ligand 5 ( 12-fold ) , and interleukin-10 ( 7-fold ) in a nuclear factor-?B dependent but angiotensin II type 1 receptor independent manner . Positive_regulation TNF PRR7 17584736 1779052 The JNK and p38 MAPK groups are major PRR effectors and are key to the *dependent* induction and release of proinflammatory cytokines such as [tumor necrosis factor] and interleukin-8 . Positive_regulation TNF PRR7 23319541 2742389 Finally , activation in SHR neuronal cultures by prorenin activated nuclear factor-?B and *increased* mRNA levels of interleukin-1ß ( 250-fold ) , [tumor necrosis factor-a] ( 32-fold ) , interleukin-6 ( 35-fold ) , C-C motif ligand 5 ( 12-fold ) , and interleukin-10 ( 7-fold ) in a nuclear factor-?B dependent but angiotensin II type 1 receptor independent manner . Positive_regulation TNF PRR9 17584736 1779060 The JNK and p38 MAPK groups are major PRR effectors and are key to the *dependent* induction and release of proinflammatory cytokines such as [tumor necrosis factor] and interleukin-8 . Positive_regulation TNF PRR9 23319541 2742397 Finally , activation in SHR neuronal cultures by prorenin activated nuclear factor-?B and *increased* mRNA levels of interleukin-1ß ( 250-fold ) , [tumor necrosis factor-a] ( 32-fold ) , interleukin-6 ( 35-fold ) , C-C motif ligand 5 ( 12-fold ) , and interleukin-10 ( 7-fold ) in a nuclear factor-?B dependent but angiotensin II type 1 receptor independent manner . Positive_regulation TNF PRSS29P 22840014 2635604 In addition , significantly enhanced the lymphocyte proliferation and *increased* the production of [TNF-a] . Positive_regulation TNF PRX 20683885 2368085 *Activation* of by [TNF] may contribute to reduced bone formation in inflammatory arthritis , menopause , and aging . Positive_regulation TNF PSEN2 19202555 2061402 Both AdVs and *induced* expression of inflammatory cytokines , such as interleukin-6 and [tumor necrosis factor-alpha] , but , most importantly , they led to a marked and dose dependent increase of cortisol and other steroid hormone production and consistently modulated expression of key steroidogenic enzymes and regulators of steroidogenesis . Positive_regulation TNF PSG1 23010818 2702292 Our results illustrated that the mitogen activated protein kinase (MAPK) pathways were simultaneously activated and involved in *induced* [TNF-a] secretion in RAW264.7 cells . Positive_regulation TNF PSG1 23194516 2718251 Furthermore , we found that acted on Toll-like receptor (TLR) 4 , signaled through p38 MAPK pathway , then activated NF-?B and *stimulated* [TNF-a] production . Positive_regulation TNF PSIP1 7694969 297259 The abilities of adPIC and to *induce* [tumor necrosis factor (TNF)] in vivo and in cultured macrophages were compared . Positive_regulation TNF PSMB9 15240699 1270375 In murine bone marrow derived macrophages , LPS and [TNF-alpha] *induced* Tap1 and up-regulated , which is constitutively expressed at low levels . Positive_regulation TNF PSMB9 15240699 1270378 In macrophages from STAT-1 knockout mice , neither LPS nor [TNF-alpha] *induced* the expression of Tap1 or . Positive_regulation TNF PTAFR 15128823 1245271 The presence of the in KB cells *resulted* in augmentation of the production of cytokines IL-8 and [TNF-alpha] induced by the chemotherapeutic agents etoposide and mitomycin C . Positive_regulation TNF PTAFR 19769579 2258178 Epidermal activation and ultraviolet B radiation *result* in synergistic [tumor necrosis factor-alpha] production . Positive_regulation TNF PTAFR 19769579 2258185 These studies suggest that concomitant activation and UVB irradiation *results* in a synergistic production of the cytokine [TNF-alpha] which is mediated in part via PKC . Positive_regulation TNF PTBP1 10861035 705051 The ligation of as well as Con A blasts by IL-12 *induced* the production of GM-CSF , IL-1beta , IL-6 , [TNF-alpha] , and IFN-gamma at the transcription levels . Positive_regulation TNF PTBP1 11035052 740863 Contrasting with our previous report using cultured splenic DCs , freshly isolated splenic killed YAC-1 cells using a Ca ( 2+ ) -independent mechanism , but this function did not appear *mediated* by Fas ligand , TNF related apoptosis inducing ligand , or [TNF-alpha] . Positive_regulation TNF PTBP1 12871639 1112533 The absence of *results* in profound [TNF] and iNOS deficiencies and an inability to clear primary bacterial infection . Positive_regulation TNF PTBP1 16317102 1532935 CD40L expressing L929 cells *induced* to produce interleukin-6 (IL-6) , [tumor necrosis factor-alpha (TNF-alpha)] , and IL-12 , which was strongly inhibited by coexpression of SLAM on the surface of the L929 cells . Positive_regulation TNF PTBP1 16622206 1551613 In addition , Campylobacter infected triggered activation of NF-kappaB and significantly *stimulated* production of interleukin-1beta (IL-1beta) , IL-6 , IL-8 , IL-10 , IL-12 , gamma interferon , and [tumor necrosis factor alpha (TNF-alpha)] compared to uninfected DCs . Positive_regulation TNF PTBP1 17296788 1698841 We show that dyslipidemia inhibited Toll-like receptor (TLR) induced production of proinflammatory cytokines , including interleukin (IL)-12 , IL-6 , and [tumor necrosis factor-alpha] , as well as *up-regulation* of costimulatory molecules by CD8alpha ( - ) , but not by CD8alpha ( + ) DCs , in vivo . Positive_regulation TNF PTBP1 17512567 1761984 After LPS stimulation , IL-6 , IL-10 , IL-12 ( p70 ) , and [TNF-alpha] levels significantly *increased* with both and DCs , but Pb-DCs produced significantly less cytokines than did DCs , except for IL-10 , which further supports Pb-DC preferential skewing toward type-2 immunity . Positive_regulation TNF PTBP1 18180802 1883482 The results show that the T-HSP70 is capable of maturing human *inducing* an increase in the expression level of the CD83 , CD86 and human leukocyte antigen-DR surface markers , as well as in the secretion of interleukin (IL)-12 , [tumor necrosis factor-alpha (TNF-alpha)] and IL-6 cytokines . Positive_regulation TNF PTBP1 19285436 2051516 Overexpression of c-Fos suppressed LPS induced cytokine production , whereas cAMP mediated suppression of [TNF-alpha] and IL-12 was *impaired* in Fos ( -/- ) or in RAW264.7 cells treated with c-Fos siRNA . Positive_regulation TNF PTBP1 20089703 2206077 The stimulation of cLP with fractalkine/CX(3)CL1 *increased* the release of IL-6 and [TNF-alpha] . Positive_regulation TNF PTBP1 20386470 2245236 LPS stimulation of *induced* IL-10 , IL-12p70 , [TNFalpha] and IL-1beta secretion , and taxol pretreatment modified this response by down regulating IL-1beta secretion whereas colchicine induced a proinflammatory cytokine profile with reduced IL-10 and increased IL-12p70 and TNFalpha secretion . Positive_regulation TNF PTBP1 20735407 2341637 Shikonin treated were poor stimulators of CD4 ( + ) T lymphocyte and *induced* lower levels of interleukin (IL)-4 , IL-5 , IL-13 and [tumour necrosis factor (TNF)-a] release by responding T-cells . Positive_regulation TNF PTBP1 22132887 2530428 Interaction of pulsed with CA9-AbOmpA fusion proteins with naive T cells *stimulated* secretion of IL-2 , interferon ( IFN ) -? and [tumour necrosis factor (TNF)-a] in T cells . Positive_regulation TNF PTBP1 22310548 2552445 EIEC triggered to produce interleukin (IL)-10 , IL-12 and tumour necrosis factor (TNF)-a , whereas S. flexneri *induced* only the production of [TNF-a] . Positive_regulation TNF PTBP1 22486596 2606867 Here , we show that parasite GPIs efficiently activate through TLR2 mediated signalling mechanism and *induce* the production of [TNF-a] and IL-12 . Positive_regulation TNF PTBP1 22611024 2691430 In rats with Bact-DNA in MLNs without GBT , intestinal and MLNs CD103 ( + ) <-DCs> showed features of activation , expansion of the proinflammatory CD4 ( + ) -DC subpopulation , *augmented* [TNF-a] production , and increased phagocytic and migratory capacities . Positive_regulation TNF PTBP1 7561684 324226 These can be expanded for several weeks by in vitro culture with c-kit-ligand , and their differentiation *requires* exogenous [TNF-alpha] in addition to GM-CSF . Positive_regulation TNF PTBP2 10861035 705048 The ligation of as well as Con A blasts by IL-12 *induced* the production of GM-CSF , IL-1beta , IL-6 , [TNF-alpha] , and IFN-gamma at the transcription levels . Positive_regulation TNF PTBP2 11035052 740860 Contrasting with our previous report using cultured splenic DCs , freshly isolated splenic killed YAC-1 cells using a Ca ( 2+ ) -independent mechanism , but this function did not appear *mediated* by Fas ligand , TNF related apoptosis inducing ligand , or [TNF-alpha] . Positive_regulation TNF PTBP2 12871639 1112530 The absence of *results* in profound [TNF] and iNOS deficiencies and an inability to clear primary bacterial infection . Positive_regulation TNF PTBP2 16317102 1532932 CD40L expressing L929 cells *induced* to produce interleukin-6 (IL-6) , [tumor necrosis factor-alpha (TNF-alpha)] , and IL-12 , which was strongly inhibited by coexpression of SLAM on the surface of the L929 cells . Positive_regulation TNF PTBP2 16622206 1551610 In addition , Campylobacter infected triggered activation of NF-kappaB and significantly *stimulated* production of interleukin-1beta (IL-1beta) , IL-6 , IL-8 , IL-10 , IL-12 , gamma interferon , and [tumor necrosis factor alpha (TNF-alpha)] compared to uninfected DCs . Positive_regulation TNF PTBP2 17296788 1698838 We show that dyslipidemia inhibited Toll-like receptor (TLR) induced production of proinflammatory cytokines , including interleukin (IL)-12 , IL-6 , and [tumor necrosis factor-alpha] , as well as *up-regulation* of costimulatory molecules by CD8alpha ( - ) DCs , but not by CD8alpha ( + ) , in vivo . Positive_regulation TNF PTBP2 17512567 1761981 After LPS stimulation , IL-6 , IL-10 , IL-12 ( p70 ) , and [TNF-alpha] levels significantly *increased* with both Pb-DCs and , but Pb-DCs produced significantly less cytokines than did DCs , except for IL-10 , which further supports Pb-DC preferential skewing toward type-2 immunity . Positive_regulation TNF PTBP2 18180802 1883479 The results show that the T-HSP70 is capable of maturing human inducing an *increase* in the expression level of the CD83 , CD86 and human leukocyte antigen-DR surface markers , as well as in the secretion of interleukin (IL)-12 , [tumor necrosis factor-alpha (TNF-alpha)] and IL-6 cytokines . Positive_regulation TNF PTBP2 19285436 2051513 Overexpression of c-Fos suppressed LPS induced cytokine production , whereas cAMP mediated suppression of [TNF-alpha] and IL-12 was *impaired* in Fos ( -/- ) or in RAW264.7 cells treated with c-Fos siRNA . Positive_regulation TNF PTBP2 20089703 2206074 The stimulation of cLP with fractalkine/CX(3)CL1 *increased* the release of IL-6 and [TNF-alpha] . Positive_regulation TNF PTBP2 20386470 2245233 LPS stimulation of *induced* IL-10 , IL-12p70 , [TNFalpha] and IL-1beta secretion , and taxol pretreatment modified this response by down regulating IL-1beta secretion whereas colchicine induced a proinflammatory cytokine profile with reduced IL-10 and increased IL-12p70 and TNFalpha secretion . Positive_regulation TNF PTBP2 20735407 2341634 Shikonin treated were poor stimulators of CD4 ( + ) T lymphocyte and *induced* lower levels of interleukin (IL)-4 , IL-5 , IL-13 and [tumour necrosis factor (TNF)-a] release by responding T-cells . Positive_regulation TNF PTBP2 22132887 2530425 Interaction of pulsed with CA9-AbOmpA fusion proteins with naive T cells *stimulated* secretion of IL-2 , interferon ( IFN ) -? and [tumour necrosis factor (TNF)-a] in T cells . Positive_regulation TNF PTBP2 22310548 2552442 EIEC triggered to produce interleukin (IL)-10 , IL-12 and tumour necrosis factor (TNF)-a , whereas S. flexneri *induced* only the production of [TNF-a] . Positive_regulation TNF PTBP2 22486596 2606864 Here , we show that parasite GPIs efficiently activate through TLR2 mediated signalling mechanism and *induce* the production of [TNF-a] and IL-12 . Positive_regulation TNF PTBP2 22611024 2691426 In rats with Bact-DNA in MLNs without GBT , intestinal and MLNs CD103 ( + ) <-DCs> showed features of activation , expansion of the proinflammatory CD4 ( + ) -DC subpopulation , *augmented* [TNF-a] production , and increased phagocytic and migratory capacities . Positive_regulation TNF PTBP2 7561684 324223 These can be expanded for several weeks by in vitro culture with c-kit-ligand , and their differentiation *requires* exogenous [TNF-alpha] in addition to GM-CSF . Positive_regulation TNF PTEN 17334236 1707601 We conclude that [TNF-alpha] *induces* upregulation of expression through NF-kappaB activation in human leukemic cells . Positive_regulation TNF PTEN 17373630 1713845 *Role* of tumor suppressor in [tumor necrosis factor] alpha induced inhibition of insulin signaling in murine skeletal muscle C2C12 cells . Positive_regulation TNF PTGES 14722058 1219629 Moreover , [TNF-alpha] *induced* by stimulating PC-PLC -- > PKC -- > NO -- > cGMP -- > PKG signal transduction pathway . Positive_regulation TNF PTGES 16766159 1654009 The results showed that IL-1beta and [TNFalpha] *induce* the expression of without inducing the expression of early growth response factor-1 (Egr-1) . Positive_regulation TNF PTGES 16816110 1580948 [TNFalpha] *induced* COX-2 and expression in neurons , followed by formation of PGE2 , which was blocked by a selective COX-2 inhibitor . Positive_regulation TNF PTGES 21075851 2376679 Interestingly , we found that activation of E-prostanoid (EP)2 and EP4 receptors , but not EP1 , EP3 , PGI(2) receptor ( IP ) , thromboxane A(2) receptor ( TP ) , PGD(2) receptor ( DP ) , and PGF ( 2 ) receptor ( FP ) , efficiently blocked LPS induced [tumor necrosis factor a (TNFa)] synthesis and COX-2 and *induction* as well as prostaglandin synthesis in spinal cultures . Positive_regulation TNF PTGES 24198734 2864391 Arzanol has been reported to *inhibit* inflammatory transcription factor NF ?B activation , HIV replication in T cells , releases of IL-1 ß , IL-6 , IL-8 , and [TNF-a] , and biosynthesis of PGE2 by potentially inhibiting enzyme . Positive_regulation TNF PTGES3 15020249 1221498 [TNFalpha] *induces* rapid activation and nuclear translocation of in human lymphocytes . Positive_regulation TNF PTGES3 15326480 1296846 The present study described that , in the leukemic KG1 cells , [TNFalpha] *induced* no apoptosis but a senescence state characterized by prolonged growth arrest , increased beta-galactosidase activity , p21WAF-1 induction , decreased activity , telomeric disturbances ( shortening , losses , fusions ) , and additional chromosomal aberrations . Positive_regulation TNF PTGS2 10065947 593535 The study indicates that the synergistic stimulation of prostaglandin production by IL-1beta , and [TNFalpha] is *mediated* partly at the level of and partly at the level of PLA2 and that PKC is involved in the signal transduction of the synergy between the two cytokines . Positive_regulation TNF PTGS2 10480491 643518 Cyclooxygenase-2 and TNFalpha were co-localized on the arterioles as well as the infiltrating neutrophils by serial-section staining , indicating that was *induced* by [TNFalpha] . Positive_regulation TNF PTGS2 10484519 644147 In the present study , we demonstrated that the inhibitor , NS-398 , *prevented* [tumor necrosis factor-alpha (TNF)-] and phorbol myristate acetate ( PMA ) -mediated increases in PGE ( 2 ) production by cultured MTAL cells . Positive_regulation TNF PTGS2 10560661 566656 Microinjection of IFN-gamma did not alter COX-2-ir , whereas [TNF-alpha] or IL-1beta injection *induced* a moderate in the perivascular cells of a few blood vessels close to the injection site , and in very few of the infiltrating neutrophils . Positive_regulation TNF PTGS2 10785514 688317 is *required* for [tumor necrosis factor-alpha-] and angiotensin II-mediated proliferation of vascular smooth muscle cells . Positive_regulation TNF PTGS2 10785514 688318 [Tumor necrosis factor-alpha (TNF-alpha)] and angiotensin II (Ang II) *induced* a transient increase in vascular smooth muscle cell ( VSMC ) mRNA accumulation , without affecting COX-1 mRNA levels . Positive_regulation TNF PTGS2 10785514 688322 The inhibitors NS-398 and nimesulide and the TXA ( 2 ) receptor antagonist BMS 180,291 *inhibited* [TNF-alpha-] and Ang II-mediated increases in DNA content and cell number by approximately 95 % . Positive_regulation TNF PTGS2 10946303 722944 [TNF-alpha] *induced* a dose- and time dependent increase in expression and PGE2 formation in human NCI-H292 epithelial cells . Positive_regulation TNF PTGS2 11179444 784689 Glutathione , a neutral SMase inhibitor , attenuated [TNF-alpha-] or SMase induced *activation* of MAPKs , COX-2 expression , and promoter activity . Positive_regulation TNF PTGS2 11266376 796730 In HT-29 and Caco-2 colonic epithelial cells , expression was *induced* by either [TNF-alpha] or interleukin (IL)-1alpha as observed by Northern and Western analyses . Positive_regulation TNF PTGS2 11356928 815784 [Tumor necrosis factor-alpha] *induces* expression and prostaglandin release in brain microvessel endothelial cells . Positive_regulation TNF PTGS2 11356928 815786 Western blot analysis showed that [TNF-alpha] had no apparent effect on the expression of COX-1 , but did *induce* the expression of in the BBMECs . Positive_regulation TNF PTGS2 11555578 859954 [Tumor necrosis factor-alpha] *induced* mPGES and in NSCLC cell lines but had no effect on the expression of either enzyme in a nontumorigenic bronchial epithelial cell line . Positive_regulation TNF PTGS2 11751489 889911 [Tumor necrosis factor-alpha] *induced* both mPGES and , but the time course and magnitude of induction differed . Positive_regulation TNF PTGS2 12354747 993634 Both LPS and [TNF-alpha] *induced* significant NFkappaB activation , expression , and inducible NO synthase (iNOS) and cytokine production ; Positive_regulation TNF PTGS2 12480916 1024256 In primary chondrocytes , [TNF-alpha] *induced* expression of the antiapoptotic protein , which persisted in the presence of SNP , and a specific Cox-2 inhibitor significantly blocked the TNF-alpha protective effect . Positive_regulation TNF PTGS2 12576525 1058077 Abrogating the induced COX-2 activity reversed the TNFalpha induced inhibition of differentiation by approximately 70 % , implying a *role* for in mediating [TNFalpha] signaling . Positive_regulation TNF PTGS2 12720581 1084115 In a macrophage cell line ( RAW 264.7 ) activated with interferon gamma plus lipopolysaccharide , both isoflavones were found to *inhibit* NO production and [tumour necrosis factor alpha (TNF-alpha)] secretion dose-dependently , but they did not affect mRNA levels for inducible nitric oxide synthase and . Positive_regulation TNF PTGS2 12858113 1110801 Recent research shows a very promising role for new hormonal medication ( aromatase inhibitors , estrogen and progesterone receptor modulators ) and anti-inflammatory drugs ( [tumor necrosis factor-alpha] *inhibitors* , matrix metalloproteinase inhibitors , inhibitors ) in the management of endometriosis . Positive_regulation TNF PTGS2 12890694 1117659 In a L929 fibroblast model , [tumor necrosis factor-alpha (TNF)] *induced* prostaglandin E2 ( PGE2 ) production by 4 h and induction as early as 2 h . Positive_regulation TNF PTGS2 12892443 1117787 The results showed that lipopolysaccharide and tumor necrosis factor alpha , or [TNF-alpha] , *induced* COX-2 in macrophages , while IL-1beta and TNF-alpha induced in oral epithelial cells . Positive_regulation TNF PTGS2 15266025 1275943 We also observed that [tumor necrosis factor (TNF)-alpha] , platelet activating factor (PAF) , and lipopolysaccharide (LPS) *induced* and increased MUC5AC production that was blocked by celecoxib , suggesting a common signaling pathway of inflammatory mediator induced MUC5AC production in NHTBE cells . Positive_regulation TNF PTGS2 16632868 1631285 Interleukin (IL) 1beta , [tumor necrosis factor-alpha (TNF-alpha)] or phorbol ester [ phorbol 12-myristate 13-acetate ( PMA ) ] *induced* the expression of , as revealed by western blot analysis . Positive_regulation TNF PTGS2 16816110 1580949 [TNFalpha] *induced* and mPGES-1 expression in neurons , followed by formation of PGE2 , which was blocked by a selective COX-2 inhibitor . Positive_regulation TNF PTGS2 17384033 1715820 By reverse-transcriptase/polymerase chain-reaction ( RT-PCR ) and Western blotting analysis , [TNF-alpha] *induced* a dose- and time dependent increase in expression . Positive_regulation TNF PTGS2 19197941 2044080 expression and PGE ( 2 ) production by MSC were not constitutive , but were *induced* by IFN-gamma and [TNF-alpha] secreted by activated Vgamma9Vdelta2 T cells . Positive_regulation TNF PTGS2 19218340 2039515 The [TNF-alpha/TNF-receptor] 1 (TNF-R1) interaction *induced* MMP-9 production and activation , as well as overexpression and PGE2 production , and increased the migration of CC cells . Positive_regulation TNF PTGS2 19218340 2039521 In conclusion , we propose a novel signaling pathway of MMP-9 up-regulation in CC cells such that [TNF-alpha] *induces* the activation of and PGE2 via TNF-R1 followed by the up-regulation of MMP-9 via the PGE2 ( EP2/4 ) receptor . Positive_regulation TNF PTGS2 19299804 2051992 Based on these results , it is suggested that the inhibition of NO and prostaglandin E ( 2 ) over production through suppressing iNOS and *induction* and attenuation of [TNF-alpha] formation and neutrophil infiltration into inflammatory sites by C-PC may contribute , at least in part , to its antihyperalgesic activity . Positive_regulation TNF PTGS2 20631885 2292015 [TNF-alpha] *induced* the expression of in A549 cells , but did not induce BEAS-2B expression . Positive_regulation TNF PTGS2 21075851 2376680 Interestingly , we found that activation of E-prostanoid (EP)2 and EP4 receptors , but not EP1 , EP3 , PGI(2) receptor ( IP ) , thromboxane A(2) receptor ( TP ) , PGD(2) receptor ( DP ) , and PGF ( 2 ) receptor ( FP ) , efficiently blocked LPS induced [tumor necrosis factor a (TNFa)] synthesis and and mPGES-1 *induction* as well as prostaglandin synthesis in spinal cultures . Positive_regulation TNF PTGS2 21269535 2443170 The results showed that L137 significantly *inhibited* both prostanoid and [TNF-a] production in lipopolysaccharide primed human monocytes in a dose dependent manner , by inhibiting the COX activity of . Positive_regulation TNF PTGS2 21417548 2463514 Furthermore , IL-1ß , [TNF] , and IL-6 also *induced* expression . Positive_regulation TNF PTGS2 21566012 2458887 We hypothesized that *induction* and cell survival signaling downstream of [TNF] are mediated by EGFR transactivation . Positive_regulation TNF PTGS2 22235849 2591902 TLR agonists and [TNF-a] *induce* transcriptional and translational expression of in vaginal cells . Positive_regulation TNF PTGS2 22800939 2645767 [Tumor necrosis factor-alpha] *induces* renal expression in response to hypercalcemia . Positive_regulation TNF PTGS2 23868940 2825264 NOD2 induced expression in macrophages was dependent on p38 mitogen activated protein kinase activation and was *mediated* by interleukin-1ß and [tumor necrosis factor-a] . Positive_regulation TNF PTGS2 7582449 333534 ( ii ) exogenous IL-1 beta , [TNF-alpha] or EGF alone *induce* activity and protein in BAEC ; Positive_regulation TNF PTGS2 9737714 531580 A number of agents , including PMA , opsonized bacteria and zymosan , LPS , GM-CSF , [TNF-alpha] , and fMLP , *induced* protein expression through signaling pathways involving transcription and protein synthesis events . Positive_regulation TNF PTH 12050269 950401 Estrogen deficiency was not associated with augmented *induced* increases in colony stimulating factor-1 , IL-1beta , IL-11 , or [TNF-alpha] . Positive_regulation TNF PTH 1435512 204805 IL-1 , [TNF] , and TPA all *increased* 92-kDa gelatinase activity in the CM of the bone cultures by about 2- to 2.5-fold . Positive_regulation TNF PTH 15195698 1260230 Results indicated that IL-1beta , [TNFalpha] , LPS but not could *increase* GFP expression of these reporter cell lines . Positive_regulation TNF PTH 8852946 387874 IL-1 and [tumor necrosis factor-alpha (TNF-alpha)] , both at 1-100 ng/ml , and at 0.1-10 nM *increased* PGHS-2 and cPLA2 mRNA and medium PGE2 levels dose-dependently after 4 h of treatment . Positive_regulation TNF PTHLH 11011119 752633 [TNF-alpha] or IL-1beta *induced* both G-CSF and production in the conditioned medium . Positive_regulation TNF PTHLH 11595209 870117 To determine whether was *induced* in glia by [TNF-alpha] , a known mediator of inflammation in brain and of PTHrP induction in peripheral tissues , and to determine whether PTHrP , in turn , mediated inflammatory changes in glia , in vitro studies with rat astrocytes and glial enriched mixed brain cells were also undertaken . Positive_regulation TNF PTHLH 11595209 870119 [TNF-alpha] *induced* expression in astrocyte and glial enriched brain cells in vitro , suggesting that this pro-inflammatory peptide was a possible mediator of PTHrP expression in CNS inflammation . Positive_regulation TNF PTK2 10653605 663302 These results suggest that ( 1 ) while and MAPK are *essential* for the production of [TNFalpha] , they are not necessary for the induction of MnSOD by LPS , and ( 2 ) while activation of NFkappaB alone is insufficient for the induction of TNFalpha mRNA by LPS , it is necessary for the induction of TNFalpha as well as MnSOD mRNAs . Positive_regulation TNF PTK2 12426001 1014297 Inhibitors of ( AG-126 ) , or JAK2 ( AG-490 ) *inhibited* [TNF-alpha] and NO production , caspase 1 activation and apoptosis , suggesting that M. tuberculosis-induction of these events depends on JAK2/STAT1-alpha activation . Positive_regulation TNF PTK2 12438325 1016572 The activation of and the serine/threonine kinases p38 MAPK and ERK was apparently *required* for MTSA-10 induction of [TNF-alpha] and NO release , as revealed by specific kinase inhibitors . Positive_regulation TNF PTK2 17719638 1842567 Pharmacological disruption of lipid rafts microdomains abolished the assembly of HLA-DR/CD18/PTK signaling complex , HLA-DR mediated tyrosine activation , and the *dependent* [TNFalpha] expression in IFNgamma primed THP-1 cells . Positive_regulation TNF PTK2 17934341 1813464 Genistein , a inhibitor , and PD153035 , an EGFR inhibitor , also *blocked* the increase of [TNF-alpha] expression by TCDD , indicating the role of EGFR in TCDD induced TNF-alpha expression . Positive_regulation TNF PTK2 8188366 256767 Finally , our results , obtained with protein tyrosine kinase inhibitors and antiphosphotyrosine Western blotting ( immunoblotting ) , indicate that is *involved* in MAM induced IL-1 beta and [TNF-alpha] gene expression in the THP-1 monocytic cell line . Positive_regulation TNF PTK2 8299229 248439 PTK and PKC activation plays a role in the induction of monokine gene transcription by SE because inhibitors of and PKC *reduced* TSST-1 stimulated IL-1 beta and [TNF-alpha] gene expression . Positive_regulation TNF PTK2 8537661 346150 The results obtained with other modulatory substances , including different protein kinase and G protein inhibitors , suggest that calmodulin dependent protein kinase , , and a cholera-toxin-sensitive G protein are *involved* in both PG- and LPS induced [TNF-alpha] release . Positive_regulation TNF PTK2 8766564 374993 LPS induced [TNF-alpha] and IL-10 expression *requires* early activation of . Positive_regulation TNF PTK2 8832967 344623 First , [TNF] production in response to viral infection is *inhibited* by the inhibitor herbimycin A as it is in response to LPS . Positive_regulation TNF PTK2 8895324 392463 Addition of these compounds resulted in a dose dependent inhibition of the stimulatory effect of IGF-I on macrophage TNF alpha release , indicating that activation is *required* for [TNF alpha] stimulation by IGF-I . Positive_regulation TNF PTK2 9120306 423861 The release of URO and THP induced [TNF-alpha] in monocytes was *dependent* upon activation that results in tyrosine phosphorylation . Positive_regulation TNF PTK2 9178968 434343 The results suggest that is *required* for FN-stimulated [TNF-alpha] secretion . Positive_regulation TNF PTK2 9178968 434346 Therefore , both and PKC may be *involved* in LPS stimulated [TNF-alpha] secretion . Positive_regulation TNF PTK2 9230816 444763 Modulation of IL-1 beta and [TNF-alpha] receptors by VLA-5 and VLA-6 *required* activation as herbimycin A ( 10 micrograms/mL ) blocked the affect of Fn and Ln . Positive_regulation TNF PTK2 9738664 531831 The inhibitor of , tyrphostin AG , *blocked* [TNF-alpha] release by only 39 +/- 4 % ( P < 0.001 compared with TNF-alpha release when added simultaneously with LPS ) when added 10 min after LPS . Positive_regulation TNF PTK2B 10597281 573593 ( RAFTK ; also known as Pyk2 ) , is a member of the Focal Adhesion Kinase ( FAK ) subfamily and is *activated* by [TNF alpha] , UV light and increases in intracellular calcium levels . Positive_regulation TNF PTK6 10653605 663303 These results suggest that ( 1 ) while and MAPK are *essential* for the production of [TNFalpha] , they are not necessary for the induction of MnSOD by LPS , and ( 2 ) while activation of NFkappaB alone is insufficient for the induction of TNFalpha mRNA by LPS , it is necessary for the induction of TNFalpha as well as MnSOD mRNAs . Positive_regulation TNF PTK6 12426001 1014298 Inhibitors of ( AG-126 ) , or JAK2 ( AG-490 ) *inhibited* [TNF-alpha] and NO production , caspase 1 activation and apoptosis , suggesting that M. tuberculosis-induction of these events depends on JAK2/STAT1-alpha activation . Positive_regulation TNF PTK6 12438325 1016573 The activation of and the serine/threonine kinases p38 MAPK and ERK was apparently *required* for MTSA-10 induction of [TNF-alpha] and NO release , as revealed by specific kinase inhibitors . Positive_regulation TNF PTK6 17719638 1842568 Pharmacological disruption of lipid rafts microdomains abolished the assembly of HLA-DR/CD18/PTK signaling complex , HLA-DR mediated tyrosine activation , and the *dependent* [TNFalpha] expression in IFNgamma primed THP-1 cells . Positive_regulation TNF PTK6 17934341 1813465 Genistein , a inhibitor , and PD153035 , an EGFR inhibitor , also *blocked* the increase of [TNF-alpha] expression by TCDD , indicating the role of EGFR in TCDD induced TNF-alpha expression . Positive_regulation TNF PTK6 8188366 256768 Finally , our results , obtained with protein tyrosine kinase inhibitors and antiphosphotyrosine Western blotting ( immunoblotting ) , indicate that is *involved* in MAM induced IL-1 beta and [TNF-alpha] gene expression in the THP-1 monocytic cell line . Positive_regulation TNF PTK6 8299229 248440 PTK and PKC activation plays a role in the induction of monokine gene transcription by SE because inhibitors of and PKC *reduced* TSST-1 stimulated IL-1 beta and [TNF-alpha] gene expression . Positive_regulation TNF PTK6 8537661 346151 The results obtained with other modulatory substances , including different protein kinase and G protein inhibitors , suggest that calmodulin dependent protein kinase , , and a cholera-toxin-sensitive G protein are *involved* in both PG- and LPS induced [TNF-alpha] release . Positive_regulation TNF PTK6 8766564 374994 LPS induced [TNF-alpha] and IL-10 expression *requires* early activation of . Positive_regulation TNF PTK6 8832967 344624 First , [TNF] production in response to viral infection is *inhibited* by the inhibitor herbimycin A as it is in response to LPS . Positive_regulation TNF PTK6 8895324 392464 Addition of these compounds resulted in a dose dependent inhibition of the stimulatory effect of IGF-I on macrophage TNF alpha release , indicating that activation is *required* for [TNF alpha] stimulation by IGF-I . Positive_regulation TNF PTK6 9120306 423862 The release of URO and THP induced [TNF-alpha] in monocytes was *dependent* upon activation that results in tyrosine phosphorylation . Positive_regulation TNF PTK6 9178968 434344 The results suggest that is *required* for FN-stimulated [TNF-alpha] secretion . Positive_regulation TNF PTK6 9178968 434347 Therefore , both and PKC may be *involved* in LPS stimulated [TNF-alpha] secretion . Positive_regulation TNF PTK6 9230816 444764 Modulation of IL-1 beta and [TNF-alpha] receptors by VLA-5 and VLA-6 *required* activation as herbimycin A ( 10 micrograms/mL ) blocked the affect of Fn and Ln . Positive_regulation TNF PTK6 9738664 531832 The inhibitor of , tyrphostin AG , *blocked* [TNF-alpha] release by only 39 +/- 4 % ( P < 0.001 compared with TNF-alpha release when added simultaneously with LPS ) when added 10 min after LPS . Positive_regulation TNF PTK7 10653605 663304 These results suggest that ( 1 ) while and MAPK are *essential* for the production of [TNFalpha] , they are not necessary for the induction of MnSOD by LPS , and ( 2 ) while activation of NFkappaB alone is insufficient for the induction of TNFalpha mRNA by LPS , it is necessary for the induction of TNFalpha as well as MnSOD mRNAs . Positive_regulation TNF PTK7 12426001 1014299 Inhibitors of ( AG-126 ) , or JAK2 ( AG-490 ) *inhibited* [TNF-alpha] and NO production , caspase 1 activation and apoptosis , suggesting that M. tuberculosis-induction of these events depends on JAK2/STAT1-alpha activation . Positive_regulation TNF PTK7 12438325 1016574 The activation of and the serine/threonine kinases p38 MAPK and ERK was apparently *required* for MTSA-10 induction of [TNF-alpha] and NO release , as revealed by specific kinase inhibitors . Positive_regulation TNF PTK7 17719638 1842569 Pharmacological disruption of lipid rafts microdomains abolished the assembly of HLA-DR/CD18/PTK signaling complex , HLA-DR mediated tyrosine activation , and the *dependent* [TNFalpha] expression in IFNgamma primed THP-1 cells . Positive_regulation TNF PTK7 17934341 1813466 Genistein , a inhibitor , and PD153035 , an EGFR inhibitor , also *blocked* the increase of [TNF-alpha] expression by TCDD , indicating the role of EGFR in TCDD induced TNF-alpha expression . Positive_regulation TNF PTK7 8188366 256769 Finally , our results , obtained with protein tyrosine kinase inhibitors and antiphosphotyrosine Western blotting ( immunoblotting ) , indicate that is *involved* in MAM induced IL-1 beta and [TNF-alpha] gene expression in the THP-1 monocytic cell line . Positive_regulation TNF PTK7 8299229 248441 PTK and PKC activation plays a role in the induction of monokine gene transcription by SE because inhibitors of and PKC *reduced* TSST-1 stimulated IL-1 beta and [TNF-alpha] gene expression . Positive_regulation TNF PTK7 8537661 346152 The results obtained with other modulatory substances , including different protein kinase and G protein inhibitors , suggest that calmodulin dependent protein kinase , , and a cholera-toxin-sensitive G protein are *involved* in both PG- and LPS induced [TNF-alpha] release . Positive_regulation TNF PTK7 8766564 374995 LPS induced [TNF-alpha] and IL-10 expression *requires* early activation of . Positive_regulation TNF PTK7 8832967 344625 First , [TNF] production in response to viral infection is *inhibited* by the inhibitor herbimycin A as it is in response to LPS . Positive_regulation TNF PTK7 8895324 392465 Addition of these compounds resulted in a dose dependent inhibition of the stimulatory effect of IGF-I on macrophage TNF alpha release , indicating that activation is *required* for [TNF alpha] stimulation by IGF-I . Positive_regulation TNF PTK7 9120306 423863 The release of URO and THP induced [TNF-alpha] in monocytes was *dependent* upon activation that results in tyrosine phosphorylation . Positive_regulation TNF PTK7 9178968 434345 The results suggest that is *required* for FN-stimulated [TNF-alpha] secretion . Positive_regulation TNF PTK7 9178968 434348 Therefore , both and PKC may be *involved* in LPS stimulated [TNF-alpha] secretion . Positive_regulation TNF PTK7 9230816 444765 Modulation of IL-1 beta and [TNF-alpha] receptors by VLA-5 and VLA-6 *required* activation as herbimycin A ( 10 micrograms/mL ) blocked the affect of Fn and Ln . Positive_regulation TNF PTK7 9738664 531833 The inhibitor of , tyrphostin AG , *blocked* [TNF-alpha] release by only 39 +/- 4 % ( P < 0.001 compared with TNF-alpha release when added simultaneously with LPS ) when added 10 min after LPS . Positive_regulation TNF PTPN1 20576518 2285478 However , TNF-alpha was able to completely blunt the leptin and insulin effect in rats treated with PTP1B-ASO , suggesting that [TNF-alpha] does not *require* to fully attenuate the leptin and insulin effects . Positive_regulation TNF PTPN11 12817006 1103561 Since recruitment of the tyrosine phosphatase Src homology protein tyrosine phosphatase 2 ( SHP2 ) to the signal transducing receptor subunit gp130 attenuates IL-6 mediated STAT-activation , we were interested in whether [TNF-alpha] also *induces* the association of to the gp130 receptor subunit . Positive_regulation TNF PTPN22 17114487 1651624 Both in vitro and in mice , *induced* MIP-2/IL-8 , [TNF-alpha] , and IL-1beta , all mediators of neutrophil recruitment and activation . Positive_regulation TNF PTPN6 16265671 1502065 Lipopolysaccharide activated motheaten microglia release *increased* nitric oxide , [TNF-alpha] , and IL-1beta . Positive_regulation TNF PTPN6 22077594 2514003 Association of 3BP2 with SHP-1 regulates *mediated* production of [TNF-a] in RBL-2H3 cells . Positive_regulation TNF PTPN6 22077594 2514007 The expression of the mutant form of which was unable to interact with 3BP2 *resulted* in the significant reduction in SHP-1 mediated [tumor necrosis factor-a (TNF-a)] production without any effects on the degranulation in antigen stimulated RBL-2H3 cells . Positive_regulation TNF PTPRC 10559228 566467 *induced* [tumor necrosis factor] alpha production in monocytes is phosphatidylinositol 3-kinase dependent and nuclear factor-kappaB independent . Positive_regulation TNF PTPRC 15554922 1338782 engagement by monoclonal antibodies on human activated T cells *triggers* [tumour necrosis factor-alpha (TNF-alpha)] gene transcription in an epitope-specific manner . Positive_regulation TNF PTPRC 8766549 374977 Epitope-specific engagement of the protein tyrosine phosphatase *induces* [tumor necrosis factor-alpha] gene expression via transcriptional mechanisms . Positive_regulation TNF PTPRC 8766549 374979 We here demonstrate that engagement of by monoclonal antibodies ( mAb ) on activated T cells *induces* [tumor necrosis factor (TNF)-alpha] as well as TNF-beta , interleukin (IL)-2 and IL-3 gene expression . Positive_regulation TNF PTPRC 8766549 374987 Nuclear run-on transcription assays demonstrated that cross linking *caused* transcriptional activation of the [TNF-alpha] gene . Positive_regulation TNF PTPRC 8766549 374989 ligation *resulted* in [TNF-alpha] secretion . Positive_regulation TNF PTTG1IP 10892857 711307 Both IL-1beta and [TNF-alpha] *induced* a significant decrease in uPA expression in PBF , whereas bFGF induced a slight increase in both HJF and . Positive_regulation TNF PTX3 10733100 678364 [TNF] and interleukin-1 (IL-1) potently *induced* expression in 3T3 fibroblasts but not in peritoneal macrophages . Positive_regulation TNF PTX3 12574336 1057837 had also *increased* allostimulatory capacity and IL-12 and [TNF-alpha] production . Positive_regulation TNF PTX3 1385797 190857 In this study , we found that differentially *regulates* the production of [TNF-alpha] and interleukin-6 (IL-6) . Positive_regulation TNF PTX3 1385797 190865 Indeed , at high concentrations *triggers* the production of IL-6 but not of [TNF-alpha] by peripheral blood mononuclear cells ( PBMC ) . Positive_regulation TNF PTX3 15201342 1281119 treatment did *induce* a greater increase of serum [tumor necrosis factor-alpha (TNF-alpha)] , but not of interleukin (IL)-1beta and IL-6 induced by in vivo administration of lipopolysaccharide (LPS) , which suggests a protective role for TNF-alpha . Positive_regulation TNF PTX3 15625444 1349279 These results suggest that of oxidative burst occurs distal to PKC and may be either due to direct inhibition of NADPH oxidase or inhibition of MAPK phosphorylation , *leading* to decreased adhesion molecule expression and [TNF-alpha] synthesis . Positive_regulation TNF PTX3 16783847 1590864 directly *induces* [TNF-alpha] and IL-2 mRNA expression , modulates the level of several cell surface receptors and induces Forkhead box p3 (Foxp3) protein accumulation in naive CD4 ( + ) T cells . Positive_regulation TNF PTX3 19617639 2112446 to a similar extent *increased* influx of leukocyte into peritoneal cavity , decreased production of [TNF] and reduced expression of VCAM-1 in vascular intima . Positive_regulation TNF PTX3 23911669 2835781 Pre-PTX and *prevented* and treated these signs of PD . PTX treatment also decreased [TNF-a] and increased IL-10 expression in the maxillae of AIA mice , although it did not affect the expression of IFN-? and IL-17 . Positive_regulation TNF PTX3 7593465 336367 Inhibitors of TNF synthesis , and thalidomide , *inhibited* [TNF] mRNA accumulation in LPS activated monocytes and down-regulated DR mRNA but not DP or DQ mRNA . Positive_regulation TNF PTX3 7679696 211303 Nuclear run-on analysis indicated that [TNF] *induces* the expression of the gene at the transcriptional level , and that de novo protein synthesis is not required for induction of TSG-14 mRNA . Positive_regulation TNF PTX4 12574336 1057836 had also *increased* allostimulatory capacity and IL-12 and [TNF-alpha] production . Positive_regulation TNF PTX4 1385797 190856 In this study , we found that differentially *regulates* the production of [TNF-alpha] and interleukin-6 (IL-6) . Positive_regulation TNF PTX4 1385797 190864 Indeed , at high concentrations *triggers* the production of IL-6 but not of [TNF-alpha] by peripheral blood mononuclear cells ( PBMC ) . Positive_regulation TNF PTX4 15201342 1281118 treatment did *induce* a greater increase of serum [tumor necrosis factor-alpha (TNF-alpha)] , but not of interleukin (IL)-1beta and IL-6 induced by in vivo administration of lipopolysaccharide (LPS) , which suggests a protective role for TNF-alpha . Positive_regulation TNF PTX4 15625444 1349278 These results suggest that of oxidative burst occurs distal to PKC and may be either due to direct inhibition of NADPH oxidase or inhibition of MAPK phosphorylation , *leading* to decreased adhesion molecule expression and [TNF-alpha] synthesis . Positive_regulation TNF PTX4 16783847 1590863 directly *induces* [TNF-alpha] and IL-2 mRNA expression , modulates the level of several cell surface receptors and induces Forkhead box p3 (Foxp3) protein accumulation in naive CD4 ( + ) T cells . Positive_regulation TNF PTX4 19617639 2112445 to a similar extent *increased* influx of leukocyte into peritoneal cavity , decreased production of [TNF] and reduced expression of VCAM-1 in vascular intima . Positive_regulation TNF PTX4 23911669 2835780 and The-PTX *prevented* and treated these signs of PD . PTX treatment also decreased [TNF-a] and increased IL-10 expression in the maxillae of AIA mice , although it did not affect the expression of IFN-? and IL-17 . Positive_regulation TNF PTX4 7593465 336366 Inhibitors of TNF synthesis , and thalidomide , *inhibited* [TNF] mRNA accumulation in LPS activated monocytes and down-regulated DR mRNA but not DP or DQ mRNA . Positive_regulation TNF PXN 10415163 631209 Concurrently , [TNF-alpha] rapidly *induced* tyrosine phosphorylation of both and focal adhesion kinase , without affecting the expression levels of these two proteins . Positive_regulation TNF PYY 1733367 181590 [TNF alpha] *induced* elevation of levels in portal plasma with no change in other gut peptide levels . Positive_regulation TNF QRICH1 7905486 240316 In contrast , production of [TNF-alpha] could be observed in the absence of glutamine and was *increased* to a limited extent by exogenous . Positive_regulation TNF QRICH2 7905486 240317 In contrast , production of [TNF-alpha] could be observed in the absence of glutamine and was *increased* to a limited extent by exogenous . Positive_regulation TNF RAB37 21805469 2495248 Release of [TNF-a] from macrophages is *mediated* by small GTPase . Positive_regulation TNF RAB7B 17395780 1766143 Here we demonstrate that can negatively *regulate* lipopolysaccharide (LPS) induced production of [tumor necrosis factor (TNF)-alpha] , IL-6 , nitric oxide , and IFN-beta , and potentiate LPS induced activation of mitogen activated protein kinase , nuclear factor kappaB , and IFN regulatory factor 3 signaling pathways in macrophages by promoting the degradation of TLR4 . Positive_regulation TNF RAB7B 19587007 2111766 Accordingly , can negatively *regulate* TLR9 triggered production of [TNF-alpha] , IL-6 , and IFN-beta in macrophages by impairing activation of MAPKs and NF-kappaB pathways . Positive_regulation TNF RABEPK 12871593 1114125 In addition to BV-2 microglial cells , p70 , p402 and also *induced* the production of [TNF-alpha] in mouse primary microglia and peritoneal macrophages . Positive_regulation TNF RABEPK 12871593 1114140 Activation of NF-kappaB as well as C/EBPbeta by p40 and inhibition of p40 induced expression of TNF-alpha by Deltap65 , a dominant negative mutant of p65 , and DeltaC/EBPbeta , a dominant negative mutant of C/EBPbeta , suggests that *induces* the expression of [TNF-alpha] through the activation of NF-kappaB and C/EBPbeta . Positive_regulation TNF RABEPK 12871593 1114175 Interestingly , PD98059 , an inhibitor of ERK , inhibited *induced* expression of [TNF-alpha] through the inhibition of C/EBPbeta , but not that of NF-kappaB , whereas SB203580 , an inhibitor of p38 MAPK , inhibited p40 induced expression of TNF-alpha through the inhibition of both NF-kappaB and C/EBPbeta . Positive_regulation TNF RABEPK 20822815 2346063 On day 12 , [TNF-a] induction in monocyte derived macrophages and IL-12 *induction* in BAL macrophages infected with R. equi was significantly higher in foals treated with PPVO than in controls . Positive_regulation TNF RAC1 11402028 842919 Moreover , studies using CD14 blocking antibodies suggest that *induces* [TNFalpha] secretion through a pathway independent of CD14 . Positive_regulation TNF RAC1 11453646 837063 The PI3K inhibitor LY294002 significantly inhibited [TNFalpha] *activation* of as well as Erk and abolished that of the PI3K target Akt , without showing any inhibitory effects on JNK and p38 activation . Positive_regulation TNF RAC1 18258304 1884770 Here we report that [TNF] induced pro-inflammatory cytokine synthesis of IL-6 and IL-8 is *mediated* by the Rho GTPase . Positive_regulation TNF RAC1 19450605 2096929 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 MAPK and inhibited cardiac TNF-alpha expression induced by LPS , suggesting an important *role* of and estrogen in LPS stimulated [TNF-alpha] expression in the heart . Positive_regulation TNF RAC1 19473519 2091154 [TNF-alpha] *induced* phosphorylation of Rac , while atorvastatin and inhibitor inhibited the phosphorylation of Rac induced by TNF-alpha . Positive_regulation TNF RAC1 20518848 2430853 The aim of this study was to investigate the *role* of in [TNF-a] expression and cardiac dysfunction during endotoxemia and to determine the involvement of phosphoinositide-3 kinase (PI3K) in lipopolysaccharide (LPS) induced Rac1 activation . Positive_regulation TNF RAC1 20518848 2430864 We conclude that PI3K mediated activation is *required* for induction of [TNF-a] expression in cardiomyocytes and cardiac dysfunction during endotoxemia . Positive_regulation TNF RAC1 21502320 2434855 In addition , [TNF-a] activation of NF-?B in NIH 3T3 cells is *dependent* on activation , as evidenced by the inhibition of TNF-a induction of NF-?B mediated transcription by a dominant inhibitory form of Rac1 . Positive_regulation TNF RAC1 21502320 2434858 A role for Rac in the inhibitory action of mGBP-2 on NF-?B is further shown by the findings that mGBP-2 inhibits [TNF-a] *activation* of endogenous and constitutively activate Rac can restore NF-?B transcription in the presence of mGBP-2 . Positive_regulation TNF RAC1 23389627 2759181 Taken together , our findings can explain the mechanisms leading to hierarchical *activation* of and RhoA by [TNF-a] through a single GEF . Positive_regulation TNF RAC2 11453646 837064 The PI3K inhibitor LY294002 significantly inhibited [TNFalpha] *activation* of as well as Erk and abolished that of the PI3K target Akt , without showing any inhibitory effects on JNK and p38 activation . Positive_regulation TNF RAC2 18258304 1884771 Here we report that [TNF] induced pro-inflammatory cytokine synthesis of IL-6 and IL-8 is *mediated* by the Rho GTPase . Positive_regulation TNF RAC2 19473519 2091155 [TNF-alpha] *induced* phosphorylation of , while atorvastatin and Rac-1 inhibitor inhibited the phosphorylation of Rac induced by TNF-alpha . Positive_regulation TNF RAC2 21502320 2434856 In addition , [TNF-a] activation of NF-?B in NIH 3T3 cells is *dependent* on activation , as evidenced by the inhibition of TNF-a induction of NF-?B mediated transcription by a dominant inhibitory form of Rac1 . Positive_regulation TNF RAC2 21502320 2434859 A role for Rac in the inhibitory action of mGBP-2 on NF-?B is further shown by the findings that mGBP-2 inhibits [TNF-a] *activation* of endogenous and constitutively activate Rac can restore NF-?B transcription in the presence of mGBP-2 . Positive_regulation TNF RAC2 23389627 2759182 Taken together , our findings can explain the mechanisms leading to hierarchical *activation* of and RhoA by [TNF-a] through a single GEF . Positive_regulation TNF RAC3 11453646 837065 The PI3K inhibitor LY294002 significantly inhibited [TNFalpha] *activation* of as well as Erk and abolished that of the PI3K target Akt , without showing any inhibitory effects on JNK and p38 activation . Positive_regulation TNF RAC3 18258304 1884772 Here we report that [TNF] induced pro-inflammatory cytokine synthesis of IL-6 and IL-8 is *mediated* by the Rho GTPase . Positive_regulation TNF RAC3 19473519 2091156 [TNF-alpha] *induced* phosphorylation of , while atorvastatin and Rac-1 inhibitor inhibited the phosphorylation of Rac induced by TNF-alpha . Positive_regulation TNF RAC3 21502320 2434857 In addition , [TNF-a] activation of NF-?B in NIH 3T3 cells is *dependent* on activation , as evidenced by the inhibition of TNF-a induction of NF-?B mediated transcription by a dominant inhibitory form of Rac1 . Positive_regulation TNF RAC3 21502320 2434860 A role for Rac in the inhibitory action of mGBP-2 on NF-?B is further shown by the findings that mGBP-2 inhibits [TNF-a] *activation* of endogenous and constitutively activate Rac can restore NF-?B transcription in the presence of mGBP-2 . Positive_regulation TNF RAC3 23389627 2759183 Taken together , our findings can explain the mechanisms leading to hierarchical *activation* of and RhoA by [TNF-a] through a single GEF . Positive_regulation TNF RAF1 17785857 1790831 Zinc dependent suppression of [TNF-alpha] production is *mediated* by protein kinase A-induced inhibition of , I kappa B kinase beta , and NF-kappa B . Positive_regulation TNF RAF1 7790814 313272 Using an enzyme linked immunosorbent assay for murine tumor necrosis factor alpha (TNF-alpha) , we found that LPS and PMA stimulation and delta : ER activation *induced* secretion of [TNF-alpha] , although the amount of TNF-alpha secreted in response to delta Raf-1 : ER activation and PMA stimulation was approximately 20-fold less than that secreted in response to LPS . Positive_regulation TNF RAF1 8790605 291147 In the same cell line , dominant negative inhibitors of ras and *block* LPS induced activation of the [TNF] promoter , as well as derepression of the translational blockade normally imposed by the TNF 3'-untranslated region . Positive_regulation TNF RAN 18390808 1925658 Previous studies showed that *augmented* serum [tumor necrosis factor (TNF)-alpha] production and hepatic neutrophil activation after LPS treatment and that both TNF-alpha and neutrophils are crucial for the liver pathogenesis . Positive_regulation TNF RAN 18390808 1925674 In summary , *enhanced* [TNF-alpha] production after LPS treatment through augmented p38 activation , and this seems to occur through TACE . Positive_regulation TNF RB1 10651228 578090 [TNF-alpha] *induced* hyperphosphorylated in SV40 transformed keratinocytes . Positive_regulation TNF RBBP4 14599803 1161393 We found that the inhibitors ( phenylbutyrate and trichostatin A ) causing histone hyperacetylation to modulate multiple gene expression not only induced the expression of p21 ( Cip1 ) and p16(INK4) in synovial cells but also *inhibited* the expression of [tumor necrosis factor-alpha] in affected tissues in adjuvant arthritis , an animal model of RA . Positive_regulation TNF RBBP4 15063780 1230945 The inhibitors butyrate and TSA *blocked* the [TNF-alpha] activation of Cox-2 protein and mRNA synthesis , and dramatically suppressed Cox-2 activity in HT-29 cells . Positive_regulation TNF RBBP7 14599803 1161394 We found that the inhibitors ( phenylbutyrate and trichostatin A ) causing histone hyperacetylation to modulate multiple gene expression not only induced the expression of p21 ( Cip1 ) and p16(INK4) in synovial cells but also *inhibited* the expression of [tumor necrosis factor-alpha] in affected tissues in adjuvant arthritis , an animal model of RA . Positive_regulation TNF RBBP7 15063780 1230946 The inhibitors butyrate and TSA *blocked* the [TNF-alpha] activation of Cox-2 protein and mRNA synthesis , and dramatically suppressed Cox-2 activity in HT-29 cells . Positive_regulation TNF RBCK1 17449468 1749605 negatively *regulates* [tumor necrosis factor-] and interleukin-1 triggered NF-kappaB activation by targeting TAB2/3 for degradation . Positive_regulation TNF RBM5 12797541 1098688 Using highly specific inhibitors of p38 ( SB203580 ) and of MAPK kinase-1 ( U0126 and PD98059 ) , we found that both p38 and ERK were essential for M. tuberculosis *induced* [TNF-alpha] production , whereas activation of the p38 pathway , but not that of ERK , was essential for M. tuberculosis H37Rv induced IL-10 production . Positive_regulation TNF RBM5 22022968 2499117 Mycobacterium tuberculosis *induced* higher Bcl-2 and lower [TNF-a] levels , whereas H37Ra the reverse . Positive_regulation TNF RBM5 8004059 257932 Heat killed was non-toxic and *induced* significant levels of [TNF-alpha] ; Positive_regulation TNF RBM8A 23817415 2815771 Of importance , Y14 significantly enhanced the binding between RIP1 and TRADD , and this is a possible new mechanism for *mediated* modification of [TNF-a] signals . Positive_regulation TNF RBMS1 12818375 1103790 also *caused* an increasing effect on the [TNF alpha] mRNA level , suggesting that the transcriptional process was involved . Positive_regulation TNF RBMS2 12169582 973882 [Tumor necrosis factor-alpha] *activation* by adenovirus E1A <13S CR3> occurs in a cell dependent and cell independent manner . Positive_regulation TNF REG3A 12579542 1058338 The *induces* lung inflammation in the rat through activation of [TNFalpha] expression in hepatocytes . Positive_regulation TNF REL 17675290 1794076 By electrophoretic mobility shift assay analyses , [TNF-alpha] and lipopolysaccharide *induce* strong p65/p50 and heterodimer binding to both NF-kappaB and TF-kappaB probes . Positive_regulation TNF REL 7957928 278117 Synergistic activation of intercellular adhesion molecule 1 ( ICAM-1 ) by [TNF-alpha] and IFN-gamma is *mediated* by p65/p50 and and interferon-responsive factor Stat1 alpha ( p91 ) that can be activated by both IFN-gamma and IFN-alpha . Positive_regulation TNF REL 8152812 253059 *Activation* of multiple NF-kappa DNA binding complexes by [tumor necrosis factor] . Positive_regulation TNF RELA 10076530 560578 CVT-634 ( 5-methoxy-1-indanone-3-acetyl-leu-D-leu-1-indanylamide ) prevented lipopolysaccharide (LPS) , [tumor necrosis factor (TNF)-] , and phorbol ester induced *activation* of in vitro by preventing signal induced degradation of I kappa B-alpha . Positive_regulation TNF RELA 10079106 595585 These findings support a pathway by which LPS stimulation of neutrophils results in activation of MKK3 , which in turn activates p38alpha MAPk , ultimately regulating adhesion , activation , *enhanced* gene expression of [TNF-alpha] , and regulation of TNF-alpha synthesis . Positive_regulation TNF RELA 10086338 599645 In particular , we demonstrate that the [TNF-alpha] effect is *mediated* by ( p50/p65 ) and RelA/RelA ( p65/p65 ) NF-kappaB complexes binding the TNF-alpha response element (TaRE) located in the region [ -252/-230 ] , with RelA acting as the transcriptional activator . Positive_regulation TNF RELA 10201927 605679 Our observations support the notion that full LPS response of [TNF] gene *requires* both and non-NF-kappaB nuclear proteins . Positive_regulation TNF RELA 10232679 611399 Treatment with N ( G ) -nitro-L-arginine methyl ester ( L-NAME ) did not affect initial *activation* of by [IL-1beta/TNF-alpha] , but unveiled an inhibitory effect of NO generation on NF-kappaB activity after 4 h . Positive_regulation TNF RELA 10342828 616510 Treatment of the cells with 17beta-E2 partially suppressed the *activation* of by [TNF alpha] , but did not block cytokine induced IL-6 secretion . Positive_regulation TNF RELA 10357911 618580 Transcriptional activation of the [TNF-alpha] gene in LPS stimulated macrophages is *dependent* upon activity . Positive_regulation TNF RELA 10385418 625463 [TNF] *induced* activation in both primary islet cells and NIT-1 cells . Positive_regulation TNF RELA 10416616 631441 The increased cytokine expression was associated with an increase in constitutive and [TNF-alpha-inducible] *activation* of as demonstrated by electrophoretic mobility shift assay and luciferase-reporter gene assay . Positive_regulation TNF RELA 10440583 635387 The role of superoxide radical in [TNF-alpha] *induced* activation . Positive_regulation TNF RELA 10449410 637274 The molecular basis for this resistance relies on an almost complete abrogation of *dependent* accumulation of [TNF-alpha] in the serum and a down-regulation of inducible nitric oxide synthase (iNOS) , leading to decreased NO synthesis , which is the main source of free radical generation during inflammation . Positive_regulation TNF RELA 10449775 637405 *Activation* of either or c-Jun NH ( 2 ) -terminal kinase/stress activated protein kinase by [tumor necrosis factor] , CD27 , and CD40 was not abrogated in traf5 ( -/- ) mice . Positive_regulation TNF RELA 10477576 643047 [TNF-alpha] rapidly *induced* marked activation of nuclear transcription factor in all 4 cell lines . Positive_regulation TNF RELA 10485710 644415 Here we show that the Akt serine-threonine kinase is involved in the *activation* of by [tumour necrosis factor (TNF)] . Positive_regulation TNF RELA 10485710 644530 Thus , both Akt and NIK are necessary for [TNF] *activation* of . Positive_regulation TNF RELA 10485710 644538 Mutation of this amino acid blocks phosphorylation by Akt or [TNF] and *activation* of . Positive_regulation TNF RELA 10486238 644708 *Role* of transcription factor in asbestos induced [TNFalpha] response from macrophages . Positive_regulation TNF RELA 10497896 647555 Induction of [TNFalpha] in macrophages by vanadate is *dependent* on activation of transcription factor and free radical reactions . Positive_regulation TNF RELA 10497896 647559 This is supported by evidence that inhibition of activation by SN50 , a specific NF-kappaB inhibitor , *resulted* in a decrease in the [TNFalpha] production . Positive_regulation TNF RELA 10498648 647629 The aim of this study is to investigate how PAF participates in the LPS induced and *mediated* regulation of [TNF-alpha] and CINC in regenerating rat livers . Positive_regulation TNF RELA 10517537 652145 To know the regulation of the expression of gamma-GCS gene , in the present study , we show evidences that gamma-GCS heavy subunit is upregulated by oxidative stress by ionizing radiation and [TNF-alpha] *mediated* by , and impairment of the expression of gamma-GCS by TNF-alpha in diabetic condition . Positive_regulation TNF RELA 10541434 563490 Fibrosis is frequently associated with inflammation , which is accompanied by increased levels of [tumor necrosis factor-alpha (TNFalpha)] and *activation* of the transcription factor . Positive_regulation TNF RELA 10544256 564106 *Activation* of by [TNF-alpha] was reproduced in primary hOBs . Positive_regulation TNF RELA 10593965 572938 These findings suggest a novel role for 5-ASA in the management of IBD by disrupting [TNFalpha] *activation* of . Positive_regulation TNF RELA 10615065 656331 however , [TNF-alpha] *induced* both AP-1 and binding activities in BET-1A cells . Positive_regulation TNF RELA 10616907 575886 We report that [TNF] induces DNA replication in growth arrested LE6 cells and that its effect *involves* the activation of and STAT3 and an increase in c-myc and IL-6 mRNAs . Positive_regulation TNF RELA 10617597 657067 Incubation of macrophages with PAO1 led to *dependent* expression of inducible nitric-oxide synthase , COX-2 , and [tumor necrosis factor-alpha] , which was unaffected by inhibition of Rac1 or Cdc42 function . Positive_regulation TNF RELA 10619820 657340 Inhibition of by pyrrolidine dithiocarbamate *attenuated* IL-1beta and [TNF-alpha] synthesis . Positive_regulation TNF RELA 10640750 660644 The *activation* of transcription factor by [TNF] involves the stimulation of a novel signaling cascade . Positive_regulation TNF RELA 10640779 660717 Our data show that [TNF-alpha] production by LPS stimulated AMs from asymptomatic HIV-seropositive and -seronegative individuals is *regulated* via the phospholipase C pathway and by DNA binding activity without obvious changes in I kappa B-alpha or I kappa B-beta protein concentrations . Positive_regulation TNF RELA 10653605 663288 In addition , inhibition of activation by gliotoxin and pyrrodiline dithiocarbamate , *inhibited* LPS induction of [TNFalpha] and MnSOD mRNAs . Positive_regulation TNF RELA 10700573 672414 Sodium valproate inhibits production of [TNF-alpha] and IL-6 and *activation* of . Positive_regulation TNF RELA 10707928 673452 In PANC-1 cells , IL-1beta and [TNF-alpha] *induced* a rapid activation of , and TGF-beta1 enhanced this activation slightly . Positive_regulation TNF RELA 10799874 691384 These effects were specific to HIV-tat , as *activation* of by PMA , LPS , H2O2 , and [TNF] was minimally affected . Positive_regulation TNF RELA 10801347 691516 Furthermore , we demonstrate that activation of [TNF-alpha] by gp350 is *mediated* by through signal transduction pathways involving PKC , PI3-K and tyrosine kinases . Positive_regulation TNF RELA 10809757 692607 The activity of [TNFalpha] was *blocked* by inhibitors . Positive_regulation TNF RELA 10815618 580209 Inhibition of *inhibits* the LPS- but not the MTP-PE induced release of [TNF-alpha] , nitric oxide and PGE2 . Positive_regulation TNF RELA 10821844 694652 We have previously shown that alpha-melanocyte stimulating hormone ( alpha-MSH ) can oppose [tumor necrosis factor] alpha *activation* of ( 1-2 h ) and intercellular adhesion molecule 1 up-regulation ( mRNA by 3 h and protein by 24 h ) in melanocytes and melanoma cells . Positive_regulation TNF RELA 10837498 699422 The following observations supported that both and AP-1 *mediated* enhanced [TNFalpha] transcription by CHG : 1 ) A 295-base pair fragment of the proximal TNFalpha promoter containing NF-kappaB and AP-1 sites reproduced the effects of CHG on TNFalpha transcription in a luciferase reporter assay , 2 ) mutational analyses of both NF-kappaB and the AP-1 sites abrogated 90 % of the luciferase activity , 3 ) gel-shift analysis using the binding sites showed activation of NF-kappaB and AP-1 in CHG nuclear extracts , and 4 ) Western blot analyses demonstrated elevated nuclear levels of p65 and p50 and decreased cytosolic levels of IkappaBalpha in CHG treated monocytes . Positive_regulation TNF RELA 10839991 699641 *Activation* of endogenous by [tumour necrosis factor-alpha (TNF-alpha)] was also able to inhibit the Smad7 promoter in human embryonic kidney 293 cells . Positive_regulation TNF RELA 10843668 700095 The effect is mediated via the p80 type II [TNF] receptor ( TNFR2 ) , which *induces* among other factors , leading to an enhanced secretion of the chemokines macrophage-inflammatory protein-1alpha , macrophage-inflammatory protein-1beta , and RANTES . Positive_regulation TNF RELA 10845915 700722 In contrast , AG-490 did not affect [tumor necrosis factor] alpha *activation* of at similar concentrations of drug . Positive_regulation TNF RELA 10878378 708966 Rotenone , an inhibitor of mitochondrial complex I , abolished the increase in ROS signal , the *activation* of , and [TNF-alpha] gene transcription during hypoxia . Positive_regulation TNF RELA 10878378 708968 These results indicate that mitochondrial ROS are required for the hypoxic activation of NF-kappa B and [TNF-alpha] gene transcription , but not for the LPS *activation* of . Positive_regulation TNF RELA 10881930 709228 IL-1beta and [TNF-alpha] *induced* a rapid activation of in PANC-1 cells , and the increase in chemokine mRNA expression correlated with NF-kappaB activation . Positive_regulation TNF RELA 10882136 709448 A dominant negative mutant of IKKepsilon blocks induction of NF-kappaB by both PMA and activation of the T cell receptor but has no effect on the *activation* of by [TNFalpha] or IL-1 . Positive_regulation TNF RELA 10884313 709536 However , pretreatment with oATP downregulated *activation* of and AP-1 by IL-1beta or [TNFalpha] . Positive_regulation TNF RELA 10921504 717358 antioxidants significantly inhibited both the in vivo and in vitro PAF induced NF-kappaB activation and *dependent* [TNF-alpha] expression . Positive_regulation TNF RELA 10930442 719830 Here we demonstrate that the *activation* of by [TNF-alpha] interferes with thyroid-hormone action as demonstrated by impairment of T ( 3 ) -dependent induction of 5'-DI gene expression in HepG2 cells . Positive_regulation TNF RELA 10930989 720127 We assessed the effect of APC on LPS induced [tumour necrosis factor alpha (TNF-alpha)] production and on the *activation* of the central proinflammatory transcription factor in a THP-1 cell line . Positive_regulation TNF RELA 10938077 737430 [TNFalpha] , as well as certain other stimuli , also *induces* the phosphorylation of the proteins . Positive_regulation TNF RELA 10938077 737435 Previously , we have shown that [TNFalpha] *induces* phosphorylation at serine 529 and that this inducible phosphorylation increases NF-kappaB transcriptional activity on an exogenously supplied reporter ( ) . Positive_regulation TNF RELA 10982776 732008 We examined whether [TNF-alpha] induction of PAP I expression was *mediated* by or MAP kinases by using specific inhibitors of both pathways . Positive_regulation TNF RELA 10984605 732219 The present study investigates the role of Akt in the *activation* of by [tumor necrosis factor-alpha] ( TNF alpha , 10 ng/ml ) and PDGF-BB ( 20 ng/ml ) in human vascular smooth muscle cells (SMC) , skin and foreskin fibroblasts . Positive_regulation TNF RELA 11007940 735638 [TNF-alpha] also *induces* the activation of and AP-1 and the subsequent increase in gamma-GCS heavy subunit transcription in these cells . Positive_regulation TNF RELA 11018074 737677 In wild-type mice , ethanol caused severe liver injury via a mechanism involving gut derived endotoxin , CD14 receptor , production of electron spin resonance-detectable free radicals , *activation* of the transcription factor , and release of cytotoxic [TNF-alpha] from activated Kupffer cells . Positive_regulation TNF RELA 11044363 742468 These TNF-alpha resistant HNSCC lines expressed TNF receptor I , and exhibited constitutive and [TNF-alpha-inducible] *activation* of as demonstrated by nuclear localization of NF-kappaB p65 by immunohistochemistry . Positive_regulation TNF RELA 11044363 742470 We conclude that HNSCC that exhibit constitutive and [TNF-alpha-inducible] *activation* of transcription factor are resistant to TNF-alpha , and that inhibition of NF-kappaB sensitizes HNSCC to TNF-alpha caspase mediated cytotoxicity . Positive_regulation TNF RELA 11045427 742601 In order to provide further understanding of determinants of TNF-alpha responses , we studied [TNF-alpha] *induced* activation and variable tumour responses . Positive_regulation TNF RELA 11045427 742603 We analysed the kinetics of [TNF-alpha] *induced* activation in colorectal cancer cells and determined whether it is possible to sensitize colorectal tumour cells to TNF-alpha by modulation of NF-kappaB signalling . Positive_regulation TNF RELA 11058855 746239 Elastase , carboxypeptidase A , and lipase induced degradation of I kappa B-beta ( but not I kappa B-alpha ) , *activation* of , and production of [TNF-alpha] protein , whereas inhibition of I kappa B with pyrrolidine dithiocarbamate attenuated this response . Positive_regulation TNF RELA 11087727 786357 [Tumor necrosis factor-alpha] *induces* distinctive signaling within human dermal fibroblasts . Positive_regulation TNF RELA 11095928 755640 Thus does not *enhance* basal or [TNF-alpha-responsive] PGHS-2 transcription in amnion derived AV-3 cells . Positive_regulation TNF RELA 11104733 756515 However , increased [ cAMP ] ( i ) in HASM neither activated NF-kappaB nor altered [TNF-alpha-] *induced* DNA binding activity . Positive_regulation TNF RELA 11112416 757588 Activation of by TNF-alpha *mediates* many functions of [TNF-alpha] . Positive_regulation TNF RELA 11179036 784432 Inhibition of myocyte activation by overexpression of myocyte I-kappaBalpha is *sufficient* to block cardiac [TNF-alpha] production and prevent cardiac dysfunction after LPS challenge . Positive_regulation TNF RELA 11225736 580996 We found that *activation* of by [TNF-alpha] was blocked by rotenone or amytal , inhibitors of complex I of the mitochondrial respiratory chain . Positive_regulation TNF RELA 11237861 790423 In the present study we investigated how TSH is involved in the *activation* of by [TNF-alpha] in the cells . Positive_regulation TNF RELA 11259437 818723 Activation of the [TNF-alpha] gene promoter was *dependent* on activation of . Positive_regulation TNF RELA 11259437 818725 Inhibition of activation *led* to a dramatic reduction in both [TNF-alpha] promoter activity and TNF-alpha protein production in the response to zymosan A. Mutation of a major NF-kappaB binding site ( kappa3 ) in the gene promoter resulted in a significant decrease in the induction of the gene promoter by zymosan A , while mutation of Egr or CRE sites failed to inhibit the response to zymosan . Positive_regulation TNF RELA 11264769 796659 An inhibition of by pyrrolidine dithiocarbamate *attenuated* IL-1beta and [TNF-alpha] synthesis . Positive_regulation TNF RELA 11279049 819485 These data show that [TNF-alpha] decreases AQP5 mRNA and protein expression and that the molecular pathway for this effect *involves* TNFR1 and activated . Positive_regulation TNF RELA 11312646 805300 tightly *regulates* [TNF-alpha] transcription . Positive_regulation TNF RELA 11336164 809290 [TNF] and IL-1 *induced* activation . Positive_regulation TNF RELA 11337375 812179 [TNF-alpha] *induced* maximal translocation of into the nucleus of non-CF as well as CF airway cells within 20 minutes . Positive_regulation TNF RELA 11356844 834472 Expression of PTEN in PC-3 cells to a level comparable with that endogenously present in DU145 cells inhibited [TNF] *activation* of . Positive_regulation TNF RELA 11382928 820942 [TNFalpha] *induces* in association with the growth and morphogenesis of normal and transformed rat mammary epithelial cells . Positive_regulation TNF RELA 11382928 820947 There were no changes in the levels of p65 or c-rel . [TNFalpha] *induced* a pronounced and sustained increase of a p50 homodimeric complex in both normal and transformed MEC . Positive_regulation TNF RELA 11385283 821642 Inhibitors of activation such as N-acetylcysteine or N-tosyl-L-phenylalanine chloromethyl ketone can *suppress* Fc epsilon RI-induced [TNF-alpha] and MCP-1 release . Positive_regulation TNF RELA 11391531 822944 In conclusion our results show that activation of the rat Mdr1b gene by [TNF-alpha] is a *result* of signaling and independent of p53 . Positive_regulation TNF RELA 11402028 842918 IKKalpha and IKKbeta were both required downstream modulators of LPS activated Rac1 , since the expression of either of the IKK dominant mutants ( IKKalphaKM or IKKbetaKA ) drastically reduced *dependent* [TNFalpha] secretion . Positive_regulation TNF RELA 11450703 836650 Thus , it is shown that the *activation* of p65/p50 by [TNF-alpha] plays a cardinal role in inducing the expression of MMP-1 , MMP-3 , ICAM-1 , and COX-2 genes , which are involved in matrix degradation and inflammatory reaction in chondrocytes , leading to chondrocytic chondrolysis . Positive_regulation TNF RELA 11461927 850945 Modulation of [tumor necrosis factor] apoptosis *inducing* ligand- induced activation by inhibition of apical caspases . Positive_regulation TNF RELA 11500081 846803 Cells insensitive to TNF-alpha may respond to [TNF-alpha] through TNFR that *induces* transcription of and FLIP . Positive_regulation TNF RELA 11500296 846997 RA did not alter LPS stimulated and activation protein-1 binding but significantly decreased TNF-alpha mRNA stability in HM. HM isolated from the ALD model showed significant decreases in all-trans RA ( -48 % ) and 9-cis RA ( -61 % ) contents , RA response element ( RARE ) binding , and mRNA levels for RARbeta , RXRalpha , and cytosolic retinol binding protein-1 , whereas [TNF-alpha] mRNA expression was *induced* . Positive_regulation TNF RELA 11505407 847915 TNFalpha induced inhibition of the EpCAM expression is mediated by [TNF] receptor 1 through the TNF receptor associated death domain protein ( TRADD ) and by the *activation* of , and it can be blocked by dominant negative variants of TRADD and the NF-kappaB inhibitor , IkappaB . Positive_regulation TNF RELA 11509005 848227 [TNF-alpha] also *induced* translocation to the nucleus , an essential step in GM-CSF mRNA production . Positive_regulation TNF RELA 11549416 856832 These findings suggested that activation of HIV-1 LTR by mycobacteria was mainly mediated by *induced* secondary release of cytokine [TNF-alpha] . Positive_regulation TNF RELA 11557763 875284 As both [TNF] and PMA rapidly *induce* activation this suggests that NEMO/IKKgamma dependent activation of the NF-kappaB pathway is necessary but not sufficient for up-regulation of TRAIL in T cells . Positive_regulation TNF RELA 11561906 862729 TGF-beta as well as [TNF-alpha] *induced* activation of and upregulated bcl-xL . Positive_regulation TNF RELA 11698503 878182 In naive cells , LPS , [TNF-alpha] , and IL-1beta *induced* IkappaBalpha degradation , kinase phosphorylation , and DNA binding . Positive_regulation TNF RELA 11753638 890160 [TNF] *induced* activation but not AP-1 activation in LNCaP cells . Positive_regulation TNF RELA 11755130 890230 In circulating blood neutrophils , [TNF-alpha] *induced* activation of , whereas , in tissue neutrophils , NF-kappa B had been already activated without any stimulation , and no further activation was induced by the treatment with TNF-alpha . Positive_regulation TNF RELA 11775855 581316 LPS might activate in the PIMs , and *induce* the increase of transcription and expression of [TNF-alpha] gene ; Positive_regulation TNF RELA 11777983 899875 EMSAs demonstrated that IL-17 , IL-1beta , and [TNF-alpha] *induced* activation within 1.5 h after stimulation , and a blockade of NF-kappaB activation by the pyrrolidine derivative of dithiocarbamate and tosyl-phe-chloromethylketone markedly reduced the IL-17- , IL-1beta- , or TNF-alpha induced IL-6 gene expression . Positive_regulation TNF RELA 11841920 912262 HM from an animal model of ALD have increased nonheme iron content accompanied by increased generation of EPR detected radicals , activation , and [TNFalpha] *induction* , all of which are normalized by ex vivo treatment of the cells with deferiprone . Positive_regulation TNF RELA 11851362 913231 Electrophoretic mobility shift assay demonstrated that [TNF-alpha] *induced* DNA binding . Positive_regulation TNF RELA 11867340 917998 In contrast , [TNF-alpha] release by IgA treated HAM is not dependent on oxidants and only partly *dependent* on . Positive_regulation TNF RELA 11896607 920952 In such a scenario , strong apoptotic agent [TNFalpha] , further *induces* activation rather than inducing apoptosis . Positive_regulation TNF RELA 11918294 925608 The nuclear transcription factor *mediates* [TNF] signaling and this transcription complex is necessary for osteoclastogenesis . Positive_regulation TNF RELA 11918684 894994 APC directly *inhibits* the production of [TNF-alpha] by inhibiting the activation of both and activator protein-1 in monocytes stimulated with LPS . Positive_regulation TNF RELA 11922866 984259 Respiratory syncytial virus and [TNF alpha] induction of chemokine gene expression *involves* differential activation of Rel A and . Positive_regulation TNF RELA 11922866 984268 DNA binding studies using NF-kappaB subunit specific binding ELISA demonstrated that RSV and [TNFalpha] *induced* different binding complexes containing Rel A ( p65 ) and NF-kappaB1 ( p50 ) . Positive_regulation TNF RELA 11934806 927866 Concomitantly , ExPLIs inhibited the LPS induced activation of by LPS but not its *activation* by [TNF-alpha] or IL-1 . Positive_regulation TNF RELA 11943805 928749 Moreover , little translocation is *induced* by [TNF-alpha] in neurons of TNFRI -/- , whereas NF-kappaB subunit p65 is still translocated from the cytoplasm into the nucleus in neurons from wild-type and TNFRII -/- mice . Positive_regulation TNF RELA 11950023 930282 [TNF] *induced* nuclear translocation and DNA binding in all OA synovial tissue explants , although there were no consistent effects on AP-1 DNA binding . Positive_regulation TNF RELA 11994432 938946 Evidence for a dual mechanism for IL-10 suppression of [TNF-alpha] production that does not *involve* inhibition of p38 mitogen activated protein kinase or in primary human macrophages . Positive_regulation TNF RELA 12010810 941311 In this study , [TNF-alpha] alone *induced* nuclear translocation , cIAP-1 and cIAP-2 up-regulation , and MM cell proliferation ; Positive_regulation TNF RELA 12022761 943300 Curcuminoids , derived from the plant Curcuma domestica Val. , have been shown to be free radical scavengers that suppress the production of superoxide by macrophages and potent anti-inflammatory agents that inhibit the lipopolysacharide (LPS) induced production of [tumor necrosis factor alpha (TNFalpha)] , interleukin (IL)-1beta , and the *activation* of in human monocytic derived cells . Positive_regulation TNF RELA 12023002 943486 Elastase induced overexpression of [TNF] messengerRNA and *activation* of was attenuated by Gd. Pancreatic elastase induces a pattern of liver injury similar to that seen during acute pancreatitis by activating cytokine production and gene expression within Kupffer cells via NF-kappa B . Positive_regulation TNF RELA 12091251 960078 RAW 264.7 macrophages exhibited enhanced TNF-alpha production and NF-kappaB activation in response to silica , whereas IC-21 macrophages did not produce [TNF-alpha] in response to silica and did not *induce* nuclear binding . Positive_regulation TNF RELA 12091251 960082 In addition , [TNF-alpha] and NF-kappaB activation , but not apoptosis , were induced by lipopolysaccharide (LPS) in both cell lines , and inhibition *reduced* LPS induced TNF-alpha release . Positive_regulation TNF RELA 12091251 960084 These data suggest that [TNF-alpha] induction is *dependent* on activation in both cell lines . Positive_regulation TNF RELA 12133965 967043 Mitogen activated protein kinases and are *involved* in [TNF-alpha] responses to group B streptococci . Positive_regulation TNF RELA 12133965 967051 Here we investigate the *role* of mitogen activated protein kinases ( MAPKs ) and in [TNF-alpha] production by human monocytes stimulated with GBS or LPS , used as a positive control . Positive_regulation TNF RELA 12133965 967058 Selective inhibitors of ERK 1/2 ( PD98059 or U0126 ) , p38 ( SB203580 ) , or ( caffeic acid phenetyl ester ( CAPE ) ) could all significantly *reduce* [TNF-alpha] production , although none of the inhibitors used alone was able to completely prevent TNF-alpha release . Positive_regulation TNF RELA 12135878 967619 [TNFalpha] *induced* IkappaB phosphorylation and activation . Positive_regulation TNF RELA 12162440 971988 Oxidative stress and [TNF-alpha] *induce* histone acetylation and activation in alveolar epithelial cells : potential mechanism in gene transcription in lung inflammation . Positive_regulation TNF RELA 12168567 973642 [Tumour necrosis factor-alpha (TNF-alpha)] or endotoxin *induce* the activation of two major transcription factors , ( nuclear factor-kappaB ) and AP-1 ( activating protein-1 ) , which in turn induce genes involved in chronic and acute inflammatory responses . Positive_regulation TNF RELA 12169272 973730 Even though LTbetaR was shown to recruit [TNF-receptor associated factor (TRAF)] 2 , 3 , and 5 , and to *induce* cell apoptosis or activation , however , the downstream signaling leading to chemokine expression is not illustrated yet . Positive_regulation TNF RELA 12176740 975493 Inhibition of by a specific NF-kappaB inhibitor , caffeic acid phenylethyl ester , or by dominant expression of the NF-kappaB inhibitory subunit IkappaB *caused* an increase in FasL induced apoptosis and a reduction in [TNF-alpha] expression . Positive_regulation TNF RELA 12181188 977496 In conclusion , Fe2+ serves as a direct agonist to activate IKK , , and TNF-alpha promoter activity and to *induce* the release of [TNF-alpha] protein by cultured Kupffer cells in a redox status dependent manner . Positive_regulation TNF RELA 12192035 980665 Mechanism of rapid transcriptional *induction* of [tumor necrosis factor] alpha-responsive genes by . Positive_regulation TNF RELA 12195699 981750 These observations strongly suggest that APC *inhibited* LPS induced [TNF-alpha] production by inhibiting the activation of both and AP-1 and that the inhibitory activity of APC might depend on its serine protease activity . Positive_regulation TNF RELA 12203103 983119 The *role* of in enhancement of [TNF-alpha] production was confirmed in experiments in which MG132 , an inhibitor of NF-kappaB activation , reversed the effect of AdAMP . Positive_regulation TNF RELA 12208496 983790 The predominant *activation* of containing kappa B complexes by [TNF] or NSMase paralleled the induction of interleukin-8 . Positive_regulation TNF RELA 12219013 986603 The 2 groups of mice were analyzed for serum levels of interferon-gamma , [tumor necrosis factor-alpha] , and interleukin-1beta as well as *activation* of and STAT1 , 2 proinflammatory transcription factors . Positive_regulation TNF RELA 12235132 1012316 The early activity *led* to the induction of proinflammatory cytokines , [tumor necrosis factor (TNF)] , and interleukin (IL)-1beta , which are known to be efficient inducers of NF-kappaB . Positive_regulation TNF RELA 12354747 993635 Both LPS and [TNF-alpha] *induced* significant activation , cyclooxygenase-2 (COX-2) expression , and inducible NO synthase (iNOS) and cytokine production ; Positive_regulation TNF RELA 12361763 995018 [TNF] alone can *induce* MCMV IE-1 gene expression and activation of and AP-1 in some tissues . Positive_regulation TNF RELA 12361763 995023 We propose that induction of IE-1 gene expression is the first step in reactivation of the virus in an immunocompromised transplant recipient , and that it occurs as a result of the allogeneic response , which induces expression of [TNF] and subsequent *activation* of , and ischemia/reperfusion injury , which induces activation of AP-1 . Positive_regulation TNF RELA 12404274 1009773 The results showed that [TNF-alpha] can *induce* activation of and that the activation and translocation of NF-kappaB into the nucleus is responsible for promoting the 3-D cytomorphologic differentiation of anaplastic thyroid carcinoma cells , which was inhibited by the NF-kappaB translocation inhibitor , NF-kappaB SN50 . Positive_regulation TNF RELA 12452437 1020565 Construction and testing of a series of promoter mutants demonstrated that is *essential* for both [TNFalpha] and IE1 stimulation . Positive_regulation TNF RELA 12452437 1020567 Specific inhibition of signalling by co-expression of a dominant negative IkappaB variant *reduced* [TNFalpha] stimulation of the IE1/2 enhancer/promoter by up to 80 % . Positive_regulation TNF RELA 12475794 1023719 [TNF-alpha] treatment and depolarization *activation* of differed significantly in that TNF-alpha activation was not blocked by PD98059 . Positive_regulation TNF RELA 12480916 1024251 Of interest , [TNF-alpha] *induced* persistent binding activity even in the presence of SNP , mirroring apoptosis protection effects . Positive_regulation TNF RELA 12490536 1037798 Inhibition of AR attenuated [TNF-alpha] and hyperglycemia induced *activation* of protein kinase C ( PKC ) , phosphorylation of the inhibitory subunit of nuclear factor-kappaB (NF-kappaB) , and stimulation of , but it did not prevent the activation of NF-kappaB and PKC by phorbol ester . Positive_regulation TNF RELA 12509805 1038769 Finally , IL-1beta and [TNF-alpha] *induced* degradation of 's bound inhibitory protein , IkappaB-alpha , leading to translocation of NF-kappaB into the nucleus . Positive_regulation TNF RELA 12556975 1051795 *Activation* of by [TNF-alpha] prior to TRAIL exposure increased resistance of the cells to TRAIL mediated apoptosis . Positive_regulation TNF RELA 12631113 1067660 The present data indicate that [TNF-alpha] *activation* of PKCzeta/iota , p42/44 MAPK , c-Jun/AP-1 , and are involved in TNF-alpha stimulated MC fractalkine expression , with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro . Positive_regulation TNF RELA 12635574 1068508 Our results indicated that [TNF-alpha] production was *induced* by D. farinae in PBMCs of patients with atopic asthma by the activation of via CD23 . Positive_regulation TNF RELA 12637573 1091954 We have shown previously that [tumor necrosis factor alpha-(TNF)] strongly *induces* osteoclastogenesis of preosteoclasts and do so through activation of the transcription factor , . Positive_regulation TNF RELA 12649382 1070549 These observations strongly suggest that gabexate mesilate *inhibited* LPS induced [TNF-alpha] production in human monocytes by inhibiting activation of both and AP-1 . Positive_regulation TNF RELA 12699902 1081661 We demonstrate in both cell types that TNF-alpha activates NF-kappaB , and HQ exposure inhibits *activation* of by [TNF-alpha] in a dose dependent manner . Positive_regulation TNF RELA 12729461 1106726 Taken together , our results demonstrate that [TNF-alpha] induces the expression of fractalkine and CX3CR1 in rat aortic SMCs and that this induction is *mediated* by activation . Positive_regulation TNF RELA 12746218 1088662 The effects of sauchinone on the inducible nitric oxide synthase (iNOS) , [tumor necrosis factor-alpha (TNF-alpha)] and cyclooxygenase 2 (COX-2) gene expression and on the *activation* of transcription factors , , CCAAT/enhancer binding protein (C/EBP) , activator protein-1 (AP-1) and cAMP-response element binding protein ( CREB ) were determined in Raw264.7 cells as part of the studies on its anti-inflammatory effects . Positive_regulation TNF RELA 12867288 1112063 The maximum activation of was *induced* by [TNF-alpha] or MoCM at a Se concentration ( 0.5 approximately 1 micromol/l ) which was half the level of the serum Se in healthy subjects and was equivalent to level in subjects with pathological conditions together with high serum CRP values . Positive_regulation TNF RELA 12867425 1141843 A role for NF-kappaB essential modifier/IkappaB kinase-gamma ( NEMO/IKKgamma ) ubiquitination in the *activation* of the by [tumor necrosis factor-alpha] . Positive_regulation TNF RELA 12874341 1115073 Activation of and AP-1 by P. aeruginosa GLP may be *involved* not only in [TNF-alpha] induction but also in many of the inflammatory responses triggered in the course of infection with P. aeruginosa . Positive_regulation TNF RELA 12885587 1116714 It is concluded that T ( 3 ) -induced oxidative stress enhances the DNA binding activity of NF-kappaB and the *dependent* expression of [TNF-alpha] and IL-10 genes . Positive_regulation TNF RELA 12917420 1157668 Remarkably , we found that *activation* of by [TNF-alpha] selectively inhibited TCDD induced serine 2 phosphorylation in mouse liver cells , suggesting that residue-specific phosphorylation of RNA PII CTD at the cyp1a1 promoter is an important regulatory point upon which signal `` cross-talk '' converges . Positive_regulation TNF RELA 12932353 1132535 We now report that in vitro exposure of neutrophils to C5a causes increased levels of IkappaBalpha , decreased *dependent* gene transcription of [TNFalpha] , and decreased lipopolysaccharide (LPS) induced TNFalpha production . Positive_regulation TNF RELA 12934647 1132831 IL-1beta and [TNF-alpha] can *induce* extracellular signal regulated kinase ( ERK ) , IKK , IkappaB degradation and activation . Positive_regulation TNF RELA 1315830 185515 mAb H398 is shown to efficiently block not only [TNF-] but also lymphotoxin mediated *activation* of . Positive_regulation TNF RELA 1315830 185517 Together , the results of this study indicate that TR55 is both necessary and sufficient for mediating [TNF] *activation* of . Positive_regulation TNF RELA 14521729 1148005 1.5 , 3.0 , 6.0 , and 12.0 hours after the onset of experiment the amount of ascitic fluid was measured , blood was extracted from abdominal aorta , changes of pancreas was observed , pancreatic tissues were stained with HE , and flow cytometry ( FCM ) and enzyme linked immuno-sorbent assay ( ELISA ) were used to examine the content of [TNF-alpha] protein and *activation* of ( number of positive cells/50 micro l ) in the pancreatic tissues . Positive_regulation TNF RELA 14527367 1148356 mRNA expression of proinflammatory cytokines ( IL-1 beta , IL-6 , [TNF-alpha] , and MCP-1 ) and *activation* of of HMC were measured using Reverse transcription-polymerase chain reaction ( RT-PCR ) and electrophoretic mobility shift assay ( EMSA ) respectively . Positive_regulation TNF RELA 14566965 1155097 In both prechondrocytes and articular chondrocytes , [TNFalpha] *induced* concentration dependent activation of MEK1/2 and , but not p38 or JNK . Positive_regulation TNF RELA 14646384 1173136 Azelastine *inhibited* hCBMC secretion of IL-6 , [TNF-alpha] and IL-8 , possibly by inhibiting intracellular Ca2+ ions and activation . Positive_regulation TNF RELA 14662866 1177642 [TNF-alpha] *activation* of , in contrast , did not increase NGAL synthesis , even though induced binding of NF-kappaB to the NGAL promoter was observed in vitro . Positive_regulation TNF RELA 14715080 1225545 We observed that *activation* of by [TNFalpha] ( tumour necrosis factor alpha ) inhibited both basal and androgen stimulated PSA expression , and that this down-regulation occurred at the promoter level , as confirmed by the super-repressor IkappaBalpha ( S32A/S36A ) , a dominant negative inhibitor of NF-kappaB . Positive_regulation TNF RELA 14736953 1199595 We investigated the *role* of and AP-1 in [tumour necrosis factor alpha (TNF-alpha)] induced monocyte chemoattractant protein 1 ( MCP-1 ) production in cultured human glomerular endothelial cells ( HGEC ) . Positive_regulation TNF RELA 14963056 1208751 The effect of eicosapentaenoic acid ( EPA ) , a major n-3 fatty acid in fish oil , on the lipopolysaccharide (LPS) induced expression of [TNF-alpha] and *activation* of were investigated . Positive_regulation TNF RELA 14980010 1213837 The increased production of NO and [TNF-alpha] from rIFN-gamma plus C. majus stimulated cells was almost completely *inhibited* by inhibitor , pyrrolidine dithiocarbamate ( 100 microM ) . Positive_regulation TNF RELA 14982564 1214340 Endotoxin caused transient production of [TNF-alpha] and IL-6 and *activation* of in the intestine at peak times of 1 , 4 and 1 h , respectively . Positive_regulation TNF RELA 14984720 1214711 We examined the effects of SUN C8079 on the transcriptional responses of NF-kappaB , on *activation* of in electrophoretic mobility shift assay , and on the gene expressions of [tumor necrosis factor (TNF)-alpha] and iNOS . Positive_regulation TNF RELA 15041472 1224415 These findings suggest that the inhibition of the LPS induced production of NO and [TNF-alpha] by the 2'-hydroxychalcone derivatives is *due* to the inhibition of and AP-1 activations . Positive_regulation TNF RELA 15068390 1184282 Kinetic experiments in HeLa cells show that [TNF] stimulation first *induced* DNA binding within 30 minutes , followed by I kappa B-alpha gene transcription 30 minutes later . Positive_regulation TNF RELA 15106733 1240537 [TNF-alpha] plus IFN-gamma can *induce* extracellular signal regulated kinase ( ERK ) , IKK , IkappaB degradation and activation . Positive_regulation TNF RELA 15144120 1247552 [TNF-alpha] expression can be *mediated* by transcription factor . Positive_regulation TNF RELA 15144120 1247554 In vitro expression of [TNF-alpha] and *activation* of in synovial fibroblasts after infection with Yersinia enterocolitica or Salmonella enteritidis was analysed by electrophoretic mobility shift assay , Western blot assay and real-time PCR . Positive_regulation TNF RELA 15177881 1255054 [TNF-alpha] stimulation , which *induces* activation , evoked up to 10-fold reduction of TFF3 expression in the colon tumour cell line HT-29 . Positive_regulation TNF RELA 15248852 1271247 The inhibitors , calpain inhibitor 1 ( 10 microm ) , pentoxifylline ( 0.5 mm ) , pyrrolidine dithiocarbamate ( PDTC , 10 microm ) or gliotoxin ( 1 pg/mL ) *reduced* the generation of GM-CSF , [TNF-alpha] and IL-8 in parallel with their inhibition of NF-kappaB . Positive_regulation TNF RELA 15265367 1275309 The *results* of EMSA showed that activation by [TNF-alpha] in HL-60 cells was induced in a dose dependent manner , but was almost completely inhibited by mutant IkappaBalpha repressor in transfected cells . Positive_regulation TNF RELA 15293554 1278961 The mRNA accumulation of IL-8 , MCP-1 , RANTES , and eotaxin , and activation of were *induced* by [TNF-alpha] for 2 h ; Positive_regulation TNF RELA 15320513 1286522 APC *inhibits* ET-induced [TNF-alpha] production in vitro in human monocytes by inhibiting activation of and AP-1 by inhibiting degradation of IkappaB and mitogen activated protein kinase pathways , respectively . Positive_regulation TNF RELA 15350531 1292410 Using a novel model of EMT in colon carcinoma in which the inflammatory cytokine TNF-alpha accelerates this TGF-beta directed process , we report that [TNF-alpha] stimulation upregulates expression of the chemokine IL-8 , and that this upregulation is *dependent* on the transcription factor . Positive_regulation TNF RELA 15464079 1305007 Anti-inflammatory drugs and [tumor necrosis factor-alpha] production from monocytes : *role* of transcription factor and implication for rheumatoid arthritis therapy . Positive_regulation TNF RELA 15481297 1320375 *regulates* the expression of [TNF] . Positive_regulation TNF RELA 15481297 1320379 Because NF-kappaB is activated by both LPS and ROS , we hypothesized that an inhibitor of , pyrrolidine dithiocarbamate ( PDTC ) , would *block* release of [TNF] from the heart stimulated by these two agents . Positive_regulation TNF RELA 15485901 1320919 These data support a model in which [TNF-alpha] *activation* of dependent-gene expression requires nuclear relocalization of p65 as well as nuclear relocalization of SIMPL , generating a TNF-alpha-specific induction of gene expression . Positive_regulation TNF RELA 15501764 1327085 In this regard , the ability of LT-IIbB to activate and *induce* [TNF-alpha] and IL-8 was antagonized by the LT-IIb holotoxin . Positive_regulation TNF RELA 15528993 1332663 Activation of *leads* to the production of proinflammatory cytokines such as IL-12 and [TNF-alpha] that are involved in innate and adaptive immunity . Positive_regulation TNF RELA 15604270 1346844 In tubular LLC-PK(1) cells , *activation* of by [TNF-alpha] resulted in HIF-1alpha protein synthesis as determined by [ ( 35 ) S ] methionine pulse experiments . Positive_regulation TNF RELA 15662752 1350341 It became known , that oxidized LDL can inhibit LPS induced binding of the NF-kappaB to DNA and the subsequent expression of [TNF-alpha] and interleukin-1beta in macrophages as well as oxidized LDL modulates *activation* of in mononuclear phagocytes by altering the degradation of I-kappaBs . Positive_regulation TNF RELA 15665514 1365459 Because the endotoxin stress response in ventricular myocytes involves the upregulation of [TNFalpha] , and the *activation* of , the effects of rosiglitazone on lipopolysaccharide induced NF-kappaB dependent transcription were also investigated . Positive_regulation TNF RELA 15665514 1365463 Treatment of neonatal rat ventricular myocytes with 10 micromol/L rosiglitazone enhanced [TNF-alpha-] and lipopolysaccharide induced *dependent* transcription by approximately 1.8- and approximately 1.4-fold respectively , and TNF-alpha induced IL-6 secretion by n1.5-fold . Positive_regulation TNF RELA 15687488 1382421 Reduction of the protein level of endogenous CPAP by RNA interference resulted in decreased *activation* of by [TNFalpha] . Positive_regulation TNF RELA 15696609 1351620 The inhibitor , pyrrolidine dithiocarbamate ( PDTC ) , *suppressed* both IL-12 and [TNF-alpha] secretions from Mo-DCs-Tum . Positive_regulation TNF RELA 15698590 1372319 However , the effects of statin on the expression of [TNF-alpha] and *activation* of in endothelial cells stimulated by CRP are less studied . Positive_regulation TNF RELA 15698590 1372331 CRP stimulation result in induction of [TNF-alpha] and *activation* of , and this effect could be significantly inhibited by fluvastatin , suggesting that CRP may play a direct role in atherogenesis by activating endothelial cells , and statins inhibit this response , which may provide an insight into the mechanisms of anti-inflammatory or anti-atherosclerotic actions of statins . Positive_regulation TNF RELA 15722197 1374639 The *activation* of and phosphatidylinositol-3 (PI3) kinase by [TNF-alpha] and TRAIL overrides the pro-apoptotic effects of these ligands in carcinoma cells and hinders their therapeutic application . Positive_regulation TNF RELA 15722553 1396053 A microarray data set generated from a time course of [TNF] stimulation in the *presence* or absence of signaling was analyzed . Positive_regulation TNF RELA 15723296 1376696 In Myd88 ( -/- ) mice after PH , induction of expression of immediate early genes involved in hepatocyte replication and phosphorylation of STAT3 in the liver , and production of [TNF-alpha/IL-6] by and *activation* of in the Kupffer cells were grossly subnormal and were associated with impaired liver regeneration . Positive_regulation TNF RELA 15777836 1384778 This enhanced [TNF alpha] production was not *due* to changes in activation , TNF alpha transcription rates , or mRNA stability . Positive_regulation TNF RELA 15800781 1417378 We sought to determine whether CARD15 mediated activation can *contribute* to MDP induced [TNFalpha] production and , consequently , if polymorphisms in both genes affect the control of such induction . Positive_regulation TNF RELA 15800781 1417385 Transfection and electrophoretic mobility shift assays ( EMSA ) experiments in HEK293 cells demonstrated that MDP exposure stimulates [TNFalpha] gene transcription , as a *result* of CARD15 induced activation and binding to TNFalpha promoter . Positive_regulation TNF RELA 15870231 1439694 PAP prevented [TNF-alpha] *induced* activation in monocytic , epithelial , and endothelial cells and reduced proinflammatory cytokine mRNA levels and adhesion molecule expression . Positive_regulation TNF RELA 15876188 1439772 In HMEC-1 and HUVEC ( human umbilical-vein endothelial cells ) , [TNFalpha] also *induced* homodimers that bound to the sequence 65-2kappaB , which specifically binds to RelA homodimers but not to NF-kappaB1/RelA heterodimers in vitro . Positive_regulation TNF RELA 15876188 1439774 These results suggest that in addition to NF-kappaB1/RelA heterodimers , [TNFalpha] also *induces* homodimers that are functionally active . Positive_regulation TNF RELA 15879145 1406060 In this study we demonstrate that a highly purified low endotoxin pancreatic elastase preparation ( El-UP ) failed both to activate and to *induce* [TNF-alpha] release in RAW 264.7 cells and bone marrow derived macrophages . Positive_regulation TNF RELA 15913942 1465007 In comparison , LPS induced a much greater activation of and TNFalpha promoters , and [TNFalpha] secretion into the supernatant was strongly *induced* . Positive_regulation TNF RELA 15925386 1440381 Our observations show that calcium , MAPK activation , HIF-1alpha , and are *necessary* for ethanol induced [TNF-alpha] and TGF-beta1 expression . Positive_regulation TNF RELA 15938622 1415425 Inhibition of by cobrotoxin *resulted* in reductions in the LPS induced expressions of COX-2 , iNOS , cPLA(2) , IL-4 , and [TNF-alpha] in astrocytes and in COX-2 expression induced by SNP , LPS , and TNF-alpha in astrocytes . Positive_regulation TNF RELA 15943902 1415946 Distinct differences between [TNF] receptor 1- and TNF receptor 2-mediated *activation* of . Positive_regulation TNF RELA 15949909 1465025 Addition of purified NSmase to ANA-1 cell cultures stimulated binding , increased transcriptional activity in cells transfected with NFkappaB responsive promoters , and *induced* [TNFalpha] expression . Positive_regulation TNF RELA 15971008 1434685 Inhibition of activity with the p65-antisense or lactacystin under static condition *blocked* the expression of most of the genes that are [TNF-alpha-inducible] and shear stress-down regulated . Positive_regulation TNF RELA 15972840 1459052 While HT is generally thought to have anti-inflammatory and cytoprotective effects , we have previously shown that moderate in vitro HT prolongs TNF-alpha production by LPS stimulated mononuclear phagocytes , in part by prolonging [TNF-alpha] gene transcription and *activation* of the pleiotropic transcription factor . Positive_regulation TNF RELA 15979856 1452534 In order to study the relationship between the constitutively active NF-kappaB and IkappaB-alpha , a dominant negative mutant IkappaB-alpha ( IkappaB-alphaDN ) , lacking the N-terminal 36 amino acids required for the *activation* of by [tumor necrosis factor-alpha (TNF-alpha)] , was expressed in the Daudi cells . Positive_regulation TNF RELA 15980040 1465297 Taken together , these data provide compelling evidence for the *role* of signaling in [TNF-alpha] gene expression in heart and highlight the importance of this proinflammatory gene-regulatory pathway as a potential therapeutic target in the management of cytokine induced myocardial dysfunction . Positive_regulation TNF RELA 15994412 1447079 In Wt mice , mtDNA depletion was avoided by selective iNOS blockade , and residual mtDNA loss was linked to *dependent* [TNF-alpha] expression . Positive_regulation TNF RELA 16006484 1459262 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of [TNF-alpha] , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the transcription factor ( ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TNF RELA 16011481 1459393 [TNFalpha] *induces* ( nuclear factor kappaB ) and AP-1 ( activator protein 1 ) nuclear binding activities . Positive_regulation TNF RELA 16020544 1453193 [Tumor necrosis factor (TNF)] superfamily receptors typically *induce* both and JNK activation by recruiting the TRAF2 signal transduction protein to their cytoplasmic domain . Positive_regulation TNF RELA 16027228 1465981 We found that UVB , IL-1 , and [TNFalpha] *induced* activation and then produced MMP-1 and bFGF in HaCaT keratinocytes and skin fibroblasts . Positive_regulation TNF RELA 16054790 1473756 These findings demonstrate that the inhibition of the LPS/rIFN-gamma induced production of NO and [TNF-alpha] by LR *involves* the inhibition of activation . Positive_regulation TNF RELA 16112155 1546729 It is known that tightly *regulates* [TNF] transcription . Positive_regulation TNF RELA 16116965 1449127 1 h , 2 h , 4 h and 6 h after LPS injection , the *activation* of in blood mononuclear cells and the content of [TNF-alpha] and IL-6 in plasma was detected by enzyme linked immunoadsordent assay ( ELISA ) . Positive_regulation TNF RELA 16123045 1467035 In vivo , [TNF-alpha] *induced* as determined by whole mouse body bioluminescence . Positive_regulation TNF RELA 16135673 1450328 Recently , we demonstrated that 3,3',5-triiodothyronine ( T3 ) induces oxidative stress in rat liver , with enhancement in the DNA binding of nuclear factor-kappaB (NF-kappaB) and the *dependent* expression of [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF RELA 16271513 1518401 [TNF-alpha] *induced* maximal translocation in these T cells , indicating that they remain receptive to alternative signaling pathways , and pulsing with IL-12 prior to TCR triggering reversed their apparent anergy . Positive_regulation TNF RELA 16274845 1518437 Beads containing an immobilized GKPV peptide were investigated for their ability to inhibit proinflammatory [tumor necrosis factor-alpha (TNF-alpha)] stimulated *activation* of in HBL cells stably transfected with an NF-kappaB-luciferase reporter construct . Positive_regulation TNF RELA 16274845 1518439 Peptide functionalized beads were compared with the ability of soluble peptide alone ( alpha-MSH or GKPV ) or non functionalized beads to inhibit [TNF-alpha] stimulated *activation* of . Positive_regulation TNF RELA 16279946 1480586 We show that activation of PAI-1 gene by [TNFalpha] and reactive oxygen species is *mediated* by interaction of with the cis acting element located in the -675 4G/5G insertion/deletion in the PAI-1 promoter . Positive_regulation TNF RELA 16297883 1502768 Dioscorin also stimulated multiple signaling molecules ( , ERK , JNK , and p38 ) and *induced* the expression of cytokines ( [TNF-alpha] , IL-1beta , and IL-6 ) in murine RAW 264.7 macrophages . Positive_regulation TNF RELA 16301661 1485236 Lung activation and neutrophil recruitment *require* IL-1 and [TNF] receptor signaling during pneumococcal pneumonia . Positive_regulation TNF RELA 16385659 1494172 To determine the functional roles of TNFR1 and TNFR2 on TNF induction , we investigated activation and [TNF-alpha] *induction* after neutralizing TNFR1 and TNFR2 by an antibody treatment . Positive_regulation TNF RELA 16385659 1494178 We found that activation and [TNF-alpha] *induction* are blocked by TNFR1 neutralizing antibody treatments . Positive_regulation TNF RELA 16408291 1540224 Furthermore , the proteasome inhibitor MG-132 caused loss of IkappaBalpha , and an increase of it is phosphorylated form , but basal NF-kappaB was unchanged , whilst *activation* of by [TNFalpha] was completely inhibited , suggesting that MG-132 activity is independent of constitutive NF-kappaB activation . Positive_regulation TNF RELA 16420740 1514804 In contrast , the broad-spectrum tyrosine kinase inhibitor genistein and the MEK-1 inhibitor ( PD98059 ) abrogated GM-CSF priming of [TNF-alpha] release and *activation* of both and AP-1 . Positive_regulation TNF RELA 16426002 1515701 [Tumor necrosis factor (TNF)] production in PBMC supernatants was measured by an enzyme linked immunosorbent assay after TLR ligand stimulation and was *dependent* on gene transcription and activation . Positive_regulation TNF RELA 16439527 1516607 Furthermore , both ectopically expressed SV5 SH and MuV SH blocked *activation* of by [TNF-alpha] in a reporter gene assay , suggesting that both SH proteins can inhibit TNF-alpha signaling . Positive_regulation TNF RELA 16475830 1524166 These results suggest that [TNF alpha] suppresses apoAI promoter activity through both the MEK/ERK and JNK pathways but is not *mediated* by either p38 MAP kinase activity or activation . Positive_regulation TNF RELA 1649771 162931 Furthermore , [TNF] induces a set of genes and at least part of this transcriptional activation is *mediated* by . Positive_regulation TNF RELA 16526022 1541907 Electrophoretic mobility shift assay revealed that *activation* of induced by [TNFalpha] is down regulated by curcumin . Positive_regulation TNF RELA 16581045 1496463 Signal transduction studies revealed that IL-1beta and [TNF-alpha] stimulation *induced* phosphorylation in A549 cells , but antagonist inhibition of NFkappaB p50-p65 phosphorylation correlated with marked reduction of IL-1beta or TNF-alpha induced CCL28 expression . Positive_regulation TNF RELA 16603398 1550702 The receptor interacting protein kinase 1 ( RIP1 ) is essential for the *activation* of by [tumor necrosis factor alpha (TNFalpha)] . Positive_regulation TNF RELA 16611629 1568851 [TNF] *induced* a quantitatively and temporally equivalent activation of in control and E1A transfected cells . Positive_regulation TNF RELA 16682409 1584044 [TNF] *induced* activation in wild-type but not in NQO1 deleted cells . Positive_regulation TNF RELA 16688828 1560308 The enhanced iNOS activity and expression were positively correlated with the liver damage , especially the necro-inflammation , *activation* of , and [TNF-alpha] mRNA expression . Positive_regulation TNF RELA 16702954 1624668 Surprisingly , activated *induced* [TNF-alpha] mRNA expression in the presence of all DNA damage inducing agents . Positive_regulation TNF RELA 16705808 1496607 DEP induced [TNF-alpha] gene expression is *regulated* at the transcriptional level by . Positive_regulation TNF RELA 16751174 1605260 Consistent with the decrease in cAMP levels , ethanol led to an increase in LPS-inducible TNF-alpha production by affecting activation and *induction* of [TNF] mRNA expression , without any change in TNF mRNA stability . Positive_regulation TNF RELA 16751383 1570977 The RASF derived exosomes , but not exosomes derived from fibroblasts obtained from individuals with osteoarthritis , are cytotoxic for the L929 cell , a [TNF-alpha-sensitive] cell line , and stimulate *activation* of and induction of collagenase-1 in RASF . Positive_regulation TNF RELA 16777921 1672116 Growth hormone activated STAT5 , and directly reduced [TNFalpha] *activation* of , in T84 cells . Positive_regulation TNF RELA 16804400 1579573 p65 , [tumor necrosis factor-alpha] , interleukin (IL)-1beta , IL-12 , and intercellular adhesion molecule-1 were *detected* by immunohistochemical staining . Positive_regulation TNF RELA 16848314 1588290 The inhibitory effect of T-614 on the production of [TNFalpha] in LPS stimulated NR8383 cells may be *mediated* by suppression of activity . Positive_regulation TNF RELA 16858424 1625424 In HaCaT cells and in reconstructed human epidermis ( RHE ) , FasL triggered a *dependent* mRNA accumulation of inflammatory cytokines ( [tumor necrosis factor-alpha] , IL-6 , and IL-1beta ) , chemokines ( CCL2/MCP-1 , CXCL1/GROalpha , CXCL3/GROgamma , and CXCL8/IL-8 ) , and the adhesion molecule ICAM-1 . Positive_regulation TNF RELA 16871588 1593192 Inhibition of p38 and activation by SB203580 and pyrrolidine dithiocarbamate , respectively , *blocked* endotoxin induced H ( 2 ) O ( 2 ) , NO , [TNF-alpha] , and IL-6 synthesis . Positive_regulation TNF RELA 16871588 1593198 In conclusion , endotoxin induced synthesis of NO , [TNF-alpha] , and IL-6 in HSCs is *mediated* by p38 and , with involvement of H ( 2 ) O ( 2 ) in TNF-alpha production . Positive_regulation TNF RELA 16873280 1593285 Rhinovirus replication in human macrophages induces *dependent* [tumor necrosis factor] alpha production . Positive_regulation TNF RELA 16879221 1593937 Further , we provide evidence for a [TNF-alpha] *induced* binding of to the recently described kappaB site in the t-PA gene and of cyclic adenosine monophosphate response element binding protein ( CREB ) to the t-PA CRE-like site . Positive_regulation TNF RELA 16924232 1692175 We found that in wild-type mouse embryonic fibroblast (MEF) , [TNF] *induced* activation as measured by DNA binding but deletion of PKR abolished this activation . Positive_regulation TNF RELA 16936197 1608938 *Activation* of by [TNF receptor associated factor (TRAF)] 2 , TRAF6 , NF-kappaB inducing kinase , or protein kinase D , which transduce signals downstream of Toll-like receptors , TNF receptors , and free radicals , respectively , were all potent activators of the A20 promoter . Positive_regulation TNF RELA 16937467 1609120 [TNF-alpha] also *induced* dependent transcriptional activity in AGS cells . Positive_regulation TNF RELA 16939707 1666198 Differential effect of Rhizoma coptidis and its main alkaloid compound berberine on [TNF-alpha] *induced* translocation in human keratinocytes . Positive_regulation TNF RELA 16943688 1609810 Thalidomide downregulates *induced* [TNF-alpha] and activates hepatic stellate cells (HSC) via inhibition of IkappaB degradation to prevent liver cirrhosis . Positive_regulation TNF RELA 16952378 1639503 This study was designed to determine whether N-acetylcysteine (NAC) , an antioxidant , prevents the *activation* of by exogenously administered [TNF-alpha] in adipocytes , and whether such change affects the production of adipocytokines . Positive_regulation TNF RELA 17008396 1674094 However , [TNF] *induced* a p52/RelB DNA binding complex in p50 null MEC nuclear extracts . Positive_regulation TNF RELA 17010424 1666322 We investigated the production of [TNF-alpha] and the *activation* of the nuclear transcription factor . Positive_regulation TNF RELA 17018860 1682935 In the resting cell , RhoA suppresses Cdc42 activation , IkappaBalpha degradation , activation , and *induction* of [TNFalpha] and NF-kappaB dependent chemokines . Positive_regulation TNF RELA 17018860 1682940 Suppression of TNFalpha induction by RhoA is Rho kinase alpha ( ROCKalpha ) independent , but Cdc42 dependent , because TNFalpha induction by C3 transferase is attenuated by inhibition of Cdc42 , and constitutively active Cdc42 suffices to activate and *induce* [TNFalpha] . Positive_regulation TNF RELA 17041226 1631071 Human cytomegalovirus IE86 attenuates virus- and [tumor necrosis factor] alpha induced *dependent* gene expression . Positive_regulation TNF RELA 17075836 1649895 RhoA mediated , [tumor necrosis factor] alpha *induced* activation of in rheumatoid synoviocytes : inhibitory effect of simvastatin . Positive_regulation TNF RELA 17082635 1643348 IL-1 beta and [TNF-alpha] regulation of the adenosine receptor (A2A) expression : differential *requirement* for binding to the proximal promoter . Positive_regulation TNF RELA 17125270 1652861 In the present study , phenolic analogues of resveratrol and a series of substituted trans-stilbenes without hydroxy groups were compared with resveratrol for their abilities to inhibit the human [tumor necrosis factor] alpha induced ( TNF-alpha ) *activation* of , using the Panomics NF-kappaB stable reporter cell line 293/NF-kappaB-luc . Positive_regulation TNF RELA 17142966 1653797 [TNFalpha] stimulation *induced* the biphasic increases in expression of , ST3Gal I , FUT IV , ST3Gal IV and ST6GalNAc III mRNAs and the transient increase in expression of ST6Gal I mRNA and the decrease in ST3GalNAc IV mRNA . Positive_regulation TNF RELA 17185631 1717324 fMLP pretreatment also inhibited *activation* of proinflammatory transcription factor by [TNF-alpha] in Caco2bbe cells , reducing induction of NF-kappaB target genes by TNF-alpha both in human intestinal biopsies and Caco2bbe cells . Positive_regulation TNF RELA 17237440 1690113 Our results demonstrate that is essential for the host defense response to pneumococcus in the lungs and that RelA in airway epithelial cells is primarily *activated* by [TNF] and IL-1 . Positive_regulation TNF RELA 17267205 1710612 The present results demonstrate that 1,25 ( OH ) ( 2 ) D ( 3 ) and 1,24 ( OH ) ( 2 ) D ( 2 ) *inhibit* [TNFalpha] expression in macrophages , by increasing IkappaBalpha and decreasing activity . Positive_regulation TNF RELA 17276889 1691895 These findings suggest that the inhibition of LPS induced NO formation and [TNF-alpha] production in microglia by ginsenosides is *due* to its inhibition of , which may be the mechanistic basis for the anti-inflammatory effects of ginsenosides . Positive_regulation TNF RELA 17303559 1718944 We find that TNF mRNA production in response to ionophore is NF-kappaB independent , but inhibition of activation *attenuates* virus- and LPS induced [TNF] mRNA levels after initial induction . Positive_regulation TNF RELA 17307735 1719148 Similarly , we showed by chromatin immunoprecipitation assays as well as by gel-shift assays with nuclear extracts that [TNF-alpha] *induced* binding to regions at positions -380 , -1420 , and -1890 , demonstrated its association with RNA polymerase II and cofactor proteins , and confirmed the functionality of the respective promoter regions in vivo . Positive_regulation TNF RELA 17321745 1711805 To elucidate the molecular mechanism of inhibition of cell adhesion molecules , we investigated the status of nuclear transcription factor-kappaB ( NF-kappaB ) and were able to establish that compound 8a significantly blocked the [TNF-alpha] induced *activation* of . Positive_regulation TNF RELA 17322278 1747578 [TNF-alpha] *induced* CD38 expression in human airway smooth muscle cells : role of MAP kinases and transcription factors and AP-1 . Positive_regulation TNF RELA 17349210 1708022 Electrophoretic mobility shift assay ( EMSA ) revealed that [TNF-alpha] *induced* transactivation in AML14 cells in a time- and dose dependent fashion , and subsequent supershift assays indicated that the translocated NF-kappaB was the heterodimer p65 ( RelA)/p50 . Positive_regulation TNF RELA 17409010 1736168 Previous studies indicated that activation by tumor necrosis factor (TNF) receptor family , which *activates* [TNF receptor associated factor (TRAF)] , induces HIV-1 expression . Positive_regulation TNF RELA 17420011 1668205 The mutant penta acylated LPS from the lpxM-strain did not induce [TNF-alpha] production in murine peritoneal macrophages , or *activation* of in transfected cells expressing murine TLR4/MD-2 . Positive_regulation TNF RELA 17434489 1729013 We also observed that is *involved* in AGE-BSA induced [TNF-alpha] . Positive_regulation TNF RELA 17473434 1738341 These findings demonstrate that the inhibition of the LPS/rIFN-gamma induced production of NO and [TNF-alpha] by MC is *due* to the inhibition of activation . Positive_regulation TNF RELA 17485223 1750544 *Activation* of by [TNF-alpha] was also abolished by preincubation of HSC with GSH , but not by deferoxamine , tempol or trolox . Positive_regulation TNF RELA 17532082 1778388 Further experiments showed that IL-6 and [TNF-alpha] production were *dependent* on , which was activated through I-kappaBalpha degradation . Positive_regulation TNF RELA 17550447 1752580 Abnormal nuclear factor (NF)-kappaB signal pathway and aspirin inhibits [tumor necrosis factor] alpha *induced* activation in keloid fibroblasts . Positive_regulation TNF RELA 17550447 1752586 In this study , we demonstrate that [TNF-alpha] *induced* activation in keloid fibroblasts , which show more sensitively than the normal skin fibroblasts . Positive_regulation TNF RELA 17551258 1785777 Exposure to Ang II ( 10 ( -6 ) M for 24 h ) also enhanced intracellular ROS elaboration and the levels of [tumor necrosis factor (TNF)-alpha] and interleukin (IL)-8 , upregulated chemokine receptor CXCR2 mRNA expression , increased adhesion of endothelial cells to monocytes and *induced* a significant increase in the activity of , which was attenuated by pretreatment with the Ang II receptor blocker losartan ( 1 , 3 and 10 muM ) . Positive_regulation TNF RELA 17553937 1792003 Twenty-four hours thereafter , splenic macrophages were isolated , and their IL-6 and [TNF-alpha] production and *activation* of MAPK and were measured . Positive_regulation TNF RELA 17567906 1763217 Functionally , transiently overexpressed Zfra sequestered ( p65 ) , WOX1 , p53 and phospho-ERK ( extracellular signal activated kinase ) in the cytoplasm , and [TNF] or UV light could not effectively *induce* nuclear translocation of these proteins . Positive_regulation TNF RELA 17583675 1764199 Rosiglitazone attenuates *dependent* ICAM-1 and [TNF-alpha] production caused by homocysteine via inhibiting ERK1/2/p38MAPK activation . Positive_regulation TNF RELA 17644514 1793197 The compounds also inhibited *dependent* [tumor necrosis factor-alpha] mRNA up-regulation . Positive_regulation TNF RELA 17660390 1799069 [TNF-alpha] *induced* and RhoA activation and upregulation of adhesion molecules ICAM-1 and VCAM-1 , increased expression of monocyte chemoattractant protein , enhanced transendothelial migration of monocytes , and augmented monocyte-endothelial adhesion . Positive_regulation TNF RELA 17669364 1780501 Artemisolide is a typical inhibitor of IkappaB kinase beta targeting cysteine-179 residue and down-regulates *dependent* [TNF-alpha] expression in LPS activated macrophages . Positive_regulation TNF RELA 17669364 1780503 Further , we demonstrate that ATM down-regulates *dependent* [TNF-alpha] expression . Positive_regulation TNF RELA 17673150 1777272 Virulizin also induced the phosphorylation of IkappaB , suggesting that induction of [TNFalpha] expression by Virulizin is *mediated* by activation of . Positive_regulation TNF RELA 17705188 1783021 Expression of M suppressed [tumor necrosis factor alpha (TNF-alpha)] *induced* activation using a luciferase reporter assay . Positive_regulation TNF RELA 17763449 1801856 Furthermore , APC directly suppressed the production of [tumor necrosis factor (TNF)] and the *activation* of and MAP kinase p38 , and inhibitors of NF-kappaB or p38 reduced the production of MMP-9 , suggesting that APC inhibits MMP-9 by blocking TNF , NF-kappaB , and p38 . Positive_regulation TNF RELA 17785857 1790832 Zinc dependent suppression of [TNF-alpha] production is *mediated* by protein kinase A-induced inhibition of Raf-1 , I kappa B kinase beta , and . Positive_regulation TNF RELA 17828497 1795610 To investigate the *role* of in [TNF-alpha] induced apoptosis in HSC-T6 , a mutant IkappaBalpha was transfected into HSC-T6 cells by lipofectin transfection technique and its transient effect was examined 48 h after the transfection . Positive_regulation TNF RELA 17855547 1818137 VZV also *inhibits* icam-1 stimulation of [TNF-alpha] by strongly reducing nuclear translocation in MRC5 fibroblasts . Positive_regulation TNF RELA 17878383 1797032 Activation of , STAT6 , and STAT1 was *induced* in eosinophils by [TNF-alpha] , IL-4 , and IFN-gamma , respectively . Positive_regulation TNF RELA 17898021 1849060 Furthermore , the increased synthesis of IL-6 and [TNF-alpha] by anionic pIgA in HMC was significantly diminished ( P < 0.01 ) in the *presence* of inhibitor pyrrolidine dithiocarbamate and NF-kappaB blocking permeable peptides SN50 ( P < 0.01 ) . Positive_regulation TNF RELA 17936907 1844356 Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli , but S. aureus fails to both activate in mammary epithelial cells and to quickly *induce* [TNFalpha] and interleukin-8 ( CXCL8 ) expression in the udder . Positive_regulation TNF RELA 17964662 1831057 Taken together , these results suggest that linomide *inhibits* [TNF-alpha] production by suppressing the activation of and mitogen activated protein kinase (MAPK) , which might , at least in part , contribute to the beneficial effects of linomide in the treatment of autoimmune diseases . Positive_regulation TNF RELA 18022363 1827537 In sensitive tumor lines , IAP antagonist induced *stimulated* production of [TNFalpha] that killed cells in an autocrine fashion . Positive_regulation TNF RELA 18022363 1827539 Inhibition of *reduced* [TNFalpha] production , and blocking NF-kappaB activation or TNFalpha allowed tumor cells to survive IAC induced apoptosis . Positive_regulation TNF RELA 18040799 1669145 *Activation* of by [TNF-alpha] and inhibition of TNF-alpha induced BDNF expression by Deltap65 ( a dominant negative mutant ) and NEMO binding domain peptide ( an inhibitor of NF-kappaB ) suggests that TNF-alpha induces BDNF expression through the activation of NF-kappaB . Positive_regulation TNF RELA 18081698 1882961 This revealed that the LPS- and [TNF-inducible] expression of ABIN-3 is *dependent* on the binding of to a specific B site in the ABIN-3 promoter . Positive_regulation TNF RELA 18089811 1834825 These findings show that the reduced bystander response in A549 cells is due to *activation* of signaling by [TNF-alpha] , whereas enhanced response to IR-induced bystander signaling in H460 cells was due to release of TRAIL associated with nuclear translocation of PAR-4 . Positive_regulation TNF RELA 18177902 1856272 Avarol inhibited [tumor necrosis factor-alpha (TNF-alpha)] generation in stimulated human monocytes ( IC ( 50 ) 1 microM ) and TNF-alpha induced *activation* of binding in keratinocytes . Positive_regulation TNF RELA 18218230 1839132 The expression of NF-kappaB and [TNFalpha] *induced* by play an important role in the pathogenesis of pneumonia . Positive_regulation TNF RELA 18235000 1864346 [TNF-alpha] *induced* the phosphorylation and downregulation of IkappaB-alpha and the translocation of the p65 subunit of to the nucleus . Positive_regulation TNF RELA 18381653 1913015 Regulation of both EAAT-1 and EAAT-2 is mediated by , and this transcriptional regulator is also *required* for increased production of [TNFalpha] . Positive_regulation TNF RELA 18393939 1913458 In conclusion , we find that can *regulate* basal [TNFalpha] and , in certain circumstances , the hypoxia induced HIF-1alpha . Positive_regulation TNF RELA 18420487 1926129 Exposure of HRECs to 25 mmol/l glucose did not stimulate endogenous ROS production , *activation* of , extracellular signal related kinase ( ERK ) , p38 and Jun NH ( 2 ) -terminal kinase ( JNK ) , tyrosine phosphorylation , interleukin (IL)-1beta , or [tumor necrosis factor-alpha (TNF-alpha)] production and only slightly affected apoptotic cell death pathways compared with normal glucose ( 5 mmol/l ) . Positive_regulation TNF RELA 18433103 1920789 It was previously demonstrated that stevioside attenuates *dependent* [TNF-alpha] and IL-1beta synthesis in LPS stimulated monocytes . Positive_regulation TNF RELA 18442881 1938508 [TNF] via TNFR1 axis *induces* , and may contribute to inflammation facilitated neoplasia . Positive_regulation TNF RELA 18450452 1908454 Knockdown of CARP-2 stabilized TNFR1 associated polyubiquitinated RIP levels after [TNF] simulation and enhanced *activation* of . Positive_regulation TNF RELA 18461339 1979042 Furthermore , cells treated with avenanthramides showed a significant inhibition of [tumor necrosis factor-alpha (TNF-alpha)] *induced* luciferase activity and subsequent reduction of interleukin-8 (IL-8) release . Positive_regulation TNF RELA 18463678 1971657 Employing a series of in vitro and in cellulo approaches , we have demonstrated that in primary human keratinocytes ( i ) [TNF-alpha] rapidly *induces* ROS generation , IkappaB degradation , p65 nuclear translocation , and ultimately production of inflammatory cytokines ; Positive_regulation TNF RELA 18547651 1940569 The activation of was *followed* by increased mRNA expression of [TNF-alpha] and IL-1beta peaking at about 20 h . Positive_regulation TNF RELA 18569074 1929849 The cellular secretion of TNF-alpha , IL-1beta , IL-6 , NO and IL-10 in supernatant , mRNA expression of [TNF-alpha] , COX-2 , iNOS and HO-1 , protein expression of COX-2 and HO-1 , and *activation* of were assayed by ELISA , the Griess method , real-time quantitative PCR , and Western blot and immunocytochemistry method , respectively . Positive_regulation TNF RELA 18599158 2208594 and ( 3 ) S100B/RAGE induced upregulation of COX-2 , IL-1beta and [TNF-alpha] expression *requires* the concurrent activation of and AP-1 . Positive_regulation TNF RELA 18637177 1942040 We have used this technique to quantitatively characterize *activation* of the transcription factor by the cytokine [TNF-alpha] . Positive_regulation TNF RELA 18641359 1937757 The presence of the PDE4 inhibitor rolipram reduces the [TNF-alpha] production and the *activation* of the three complexes . Positive_regulation TNF RELA 18662886 1972997 [TNF-alpha] *induced* rapid activation in both HT-29 and FHC cell lines and this effect was differently modulated by NaBt in these two cell lines . Positive_regulation TNF RELA 18687753 1973594 Our recent studies showed that chronic ethanol exposure significantly decreased cellular cAMP levels in both LPS stimulated and unstimulated monocytes and Kupffer cells , leading to an increase in LPS-inducible TNF-alpha production by affecting activation and *induction* of [TNF] mRNA expression . Positive_regulation TNF RELA 18697935 1950338 The cellular inhibitor of apoptosis 1 and 2 ( cIAP1 and cIAP2 ) proteins have been implicated in the *activation* of by [TNFalpha] ; however , genetic deletion of either cIAP1 or 2 did not support a physiologically relevant role , perhaps because of functional redundancy . Positive_regulation TNF RELA 18753141 1980020 [Tumor necrosis factor-alpha] *induced* the maximal S100A6 promoter and transcription factor ( p65 subunit ) . Positive_regulation TNF RELA 18804339 2099792 We also determined the expression of TLR4 mRNA and MyD88 mRNA by in situ hybridization ( ISH ) , the *activation* of by EMSA , and the expression of [TNF-alpha] protein by Western blot . Positive_regulation TNF RELA 18804339 2099796 The expression of TLR4 mRNA and MyD88 mRNA , the *activation* of , and the expression of [TNF-alpha] protein showed clear difference as well . Positive_regulation TNF RELA 18832697 1971195 Glucocorticoid induced [TNF] receptor expression by T cells is reciprocally *regulated* by and NFAT . Positive_regulation TNF RELA 18996370 2016017 Inhibition of NF-kappaB activity by short interfering RNA mediated knock-down of p65 impairs , while *activation* of activity by [TNF-alpha] synergizes induction of NF-kappaB target genes by LMX1B . Positive_regulation TNF RELA 19023660 2035112 This study examines the *role* of in the regulation of [TNFalpha] production by morphine in microglia . Positive_regulation TNF RELA 1905804 161651 Our results suggest that maximal transcriptional activation of the uPA gene by PMA , IL-1 and [TNF alpha] *requires* the induction of activity and the decay of a short lived repressor protein , possibly IkB . Positive_regulation TNF RELA 19067146 2024074 The TNBS treatment caused colon shortening , increased myeloperoxidase activity , *induced* IL-1beta , [TNF-alpha] , and IL-6 expression in the colon , activated , and potentiated the GAG degrading activities of intestinal microflora . Positive_regulation TNF RELA 19088456 2003737 ( 2 ) [TNF] induced *upregulation* of promoter activity by nuclear translocation ; Positive_regulation TNF RELA 19096114 2003922 To test this hypothesis , we studied the effect of CoQ10 on the *dependent* pro-inflammatory cytokine [TNF-alpha] . Positive_regulation TNF RELA 19151401 2079185 PolyI : C , flagellin , or [TNF-alpha] also *induced* p65 protein nuclear translocation . Positive_regulation TNF RELA 19271152 2106014 Ang II upregulates the expression of TLR4 by RPMCs , resulting in enhanced signaling and *induction* of CD40 , [TNF-alpha] , and IL-6 expression . Positive_regulation TNF RELA 19273239 2045830 *Activation* of by [TNF-alpha] , up-regulates the expression of molecules which are involved in inflammation and cell adhesion . Positive_regulation TNF RELA 19284955 2046500 [TNF-alpha] ( 1 microg/L ) strongly *induced* the expression of by approximately 1.76-fold compared with the control in the nuclei of A549 cells , and the induced NF-kappaB expression was significantly suppressed by addition of Feiyanning ( P < 0.01 ) . Positive_regulation TNF RELA 19286451 2072937 Our findings suggest that can *mediate* induction of COX-2 , [TNFalpha] and astrogliosis in APPswe/PS1dE9 mice . Positive_regulation TNF RELA 19287189 2046612 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Positive_regulation TNF RELA 19369349 2088999 PKR dependent activation of p38 and NF-kappaB was required for vaccinia virus induced INHBA expression , whereas induction of [TNF-alpha] *required* only PKR dependent activation . Positive_regulation TNF RELA 19379593 2065654 It is concluded that the [TNF-alpha] *induces* expressions of IL-8 mRNA , MCP-1 mRNA and NF-kappaB in HUVECs , and activities signal pathway may play a role in IL-8 mRNA and MCP-1 mRNA expressions . Positive_regulation TNF RELA 19393188 2070140 These results indicate that canonical signaling is *required* for [TNF] induction of the notch ligand jagged-1 in EC . Positive_regulation TNF RELA 19479048 2085738 [TNFalpha] signaling is *mediated* by the transcription factor , , which regulates genes controlling several physiological processes including the innate immune responses , cell death , and inflammation . Positive_regulation TNF RELA 19514995 2092717 MW *inhibited* secretion of [TNF-alpha] , IL-6 , and IL-8 possibly by inhibiting activation . Positive_regulation TNF RELA 19596777 2122947 While activation of was *essential* for heat inactivated S. aureus induced [TNF-alpha] and NO , inhibiting GSK-3beta blocked heat inactivated S. aureus induced NF-kappaB p65 nuclear translocation . Positive_regulation TNF RELA 19620400 2137539 Endothelial blockade prevented LPS down-regulation of endothelial protein C receptor (EPCR) and thrombomodulin protein expressions , *inhibited* tissue [tumor necrosis factor-alpha] converting enzyme activity , reduced EPCR shedding , and restored plasma protein C level . Positive_regulation TNF RELA 19640904 2138167 This indicated that PPAR-alpha attenuated renal I/R injury via *induced* [TNF-alpha] overexpression . Positive_regulation TNF RELA 19640904 2138170 Taken together , our results demonstrate for the first time that prostacyclin induces the translocation of PPAR-alpha from the cytosol into the nucleus and attenuates induced [TNF-alpha] *activation* following renal I/R injury . Positive_regulation TNF RELA 19683526 2132970 It was further observed that inhibitor but not c-Jun N-terminal kinase inhibitor ( SP600125 ) *suppressed* [TNF-alpha] expression . Positive_regulation TNF RELA 19689081 2126519 The results suggested LPS might activate in peritoneal macrophages and *induce* the increase of transcription and expression of [TNF-alpha] , IL-1beta , IL-6 genes ; Positive_regulation TNF RELA 19699180 2139090 The most ancient part , lipid A is crucial in evoking immediate [TNF] release and *activation* of . Positive_regulation TNF RELA 19706600 2151479 [Tumor necrosis factor-alpha] *induces* degradation via ubiquitination at lysine 195 to prevent excessive nuclear factor-kappaB activation . Positive_regulation TNF RELA 19721818 2133739 In vitro studies with the ester dimethyl fumarate ( DMF ) described an inhibitory effect on *dependent* transcription of [tumor necrosis factor-alpha (TNF-alpha)] induced genes in human endothelial cells . Positive_regulation TNF RELA 19726342 2134029 [TNF-alpha] *induced* the activation of and increased the expressions of IL-6 and sICAM-1 in HUVECs . Positive_regulation TNF RELA 19751407 2135262 We recently reported that the nucleocapsid ( N ) protein of HFRS causing Hantaan virus ( HTNV ) inhibits [tumor necrosis factor-alpha (TNF-alpha)] *activation* of . Positive_regulation TNF RELA 19751407 2135264 We found that like HTNV N , the N proteins of HFRS causing Seoul and Dobrava viruses inhibited [TNF-alpha] *activation* of and translocation of the NF-kappaB p65 subunit , but did not interfere with degradation of inhibitor of NF-kappaB ( IkappaB ) . Positive_regulation TNF RELA 19751407 2135266 In contrast , the HFRS causing Puumala virus and the HPS causing Andes and Sin Nombre viruses did not prevent [TNF-alpha] *activation* of or nuclear translocation of p65 . Positive_regulation TNF RELA 19763702 2175971 High fat diet increased hepatic levels of SREBP-1c , TLR4 , [TNF-alpha] , and IL-6 protein and mRNA and increased *activation* of . Positive_regulation TNF RELA 19801900 2148232 Vaspin did not inhibit the [TNF-alpha] ( 20 min ) *activation* of JNK , p38 and , but only slightly inhibited Akt . Positive_regulation TNF RELA 1986224 152165 The *activation* of activities ( called NF-kappa B ) by [tumor necrosis factor alpha (TNF alpha)] and the phorbol ester phorbol 12-myristate 13-acetate ( PMA ) were compared . Positive_regulation TNF RELA 1986224 152171 We suggest that cell-specific differences in the protein kinase C-dependent activation of NF-kappa B may exist and that [TNF alpha] and PMA may *induce* expression of the gene ( s ) encoding . Positive_regulation TNF RELA 19874203 2258360 We investigated the effects of EPA on differentiation of RAW264.7 monocyte/macrophage cells induced by receptor activator of NF-kappaB ligand ( RANKL ) and on *activation* of by [tumor necrosis factor alpha (TNF-alpha)] or exposure to modeled weightlessness . Positive_regulation TNF RELA 20045454 2205378 The *activation* of by [TNF] was completely blocked by a Lagerstroemia speciosa extract in a dose- and time dependent manner in H9c2 cells . Positive_regulation TNF RELA 20051532 2225367 Pharmacologic inhibition of signaling with SN50 *prevented* both [TNF-alpha] release and Mrp1 expression changes in astrocytes triggered with gp120 ; Positive_regulation TNF RELA 20052674 2211737 *Activation* of by [TNFalpha] enhances p50/RelA binding to the NF-kappaB binding sites . Positive_regulation TNF RELA 20185819 2236860 In contrast , *activation* of by [TNF] did not depend on TRAF3 levels . Positive_regulation TNF RELA 20205746 2229738 [TNF-alpha] significantly *induced* phosphorylation of at Ser 536 and Ser 468 , but not at Ser 529 or Ser 276 . Positive_regulation TNF RELA 20205746 2229767 These results strongly suggest that [TNF-alpha] *induces* IL-6 synthesis through the JAK/STAT3 pathway in addition to p38 MAP kinase and SAPK/JNK in C6 glioma cells , and that phosphorylation of at Ser 536 and Ser 468 , and NADPH oxidase are involved in TNF-alpha stimulated IL-6 synthesis . Positive_regulation TNF RELA 20206688 2243317 The *dependent* gene expression of IL8 , IL6 , PTGS2/COX2 , [TNF] and IL33 in directly irradiated human skin fibroblasts produced the cytokines and prostaglandin E2 ( PGE2 ) with autocrine/paracrine functions , which further activated signaling pathways and induced NF-kappaB dependent gene expression in bystander cells . Positive_regulation TNF RELA 20220144 2249435 As IL-17 stimulation stabilizes the IkappaB-zeta transcript , we propose a model where [TNF-alpha] *induces* activation and binding of to the promoters of both NFKBIZ and LCN2 genes but induce only transcription of IkappaB-zeta . Positive_regulation TNF RELA 20353839 2273287 *Activation* of by fluid shear stress , but not [TNF-alpha] , requires focal adhesion kinase in osteoblasts . Positive_regulation TNF RELA 20353839 2273293 Interestingly , FAK was not required for [TNF-alpha] *induced* activation in osteoblasts . Positive_regulation TNF RELA 20356387 2255199 Moreover , we explored the mechanism governing the expression of ATX in hepatoma cells and established a critical *role* of in basal and [TNF-alpha] induced ATX expression . Positive_regulation TNF RELA 20363280 2261070 Further studies revealed that EC extracts suppress the production of [tumor necrosis factor-alpha (TNF-alpha)] and *activation* of . Positive_regulation TNF RELA 20367887 2245075 Our data demonstrate that MA can potentiate the anti-tumor activities of [TNFalpha] and *inhibit* pancreatic tumor growth and invasion by activating caspase dependent apoptotic pathway and by suppressing activation and its downstream gene expression . Positive_regulation TNF RELA 20385167 2267202 Also , 1alpha,25 ( OH ) ( 2 ) D ( 3 ) did not suppress the *activation* of by [TNFalpha] or PHA . Positive_regulation TNF RELA 20499049 2276449 The results obtained from this study revealed that CTB glycoprotein ( 100 microg/ml ) inhibits the translocation of PKC from cytosol to the membrane , the phosphorylation of p38 MAPK , the *activation* of , and the expression levels of [TNF-alpha] and IL-6 . Positive_regulation TNF RELA 20499049 2276517 Taken together , the results in this study suggest that CTB glycoprotein *inhibits* the expression of allergic inflammation related cytokines ( [TNF-alpha] and IL-6 ) by blocking and p38 kinase in BPA induced HMC-1 cells . Positive_regulation TNF RELA 20514534 2289506 These results link the gliadin derived peptides induced [TNFalpha] production through cAMP dependent PKA activation , where ion channels controlling calcium influx into cells could play a protective role , and *requires* activation . Positive_regulation TNF RELA 20529958 2289643 In contrast , *activation* of by [TNF-alpha] was not affected . Positive_regulation TNF RELA 2056282 162025 Therefore , [TNF-alpha] mRNA induction by PMA , like its induction by virus and LPS , is not primarily *mediated* by , but rather is mediated through other sequences and protein factors . Positive_regulation TNF RELA 20566376 2302595 The results show that CSE resulted in increasing IL-8 , IL-6 and [TNF-alpha] expression and *activation* of . Positive_regulation TNF RELA 20599720 2290814 In addition to Ca2+ mobilization through the IP3-receptor , TRPV2 mediated intracellular Ca2+ mobilization is involved in *dependent* [TNFalpha] and IL-6 expression , while extracellular Ca2+ entry is involved in NFkappaB independent IL-6 production . Positive_regulation TNF RELA 2065663 162376 NAC and other thiol compounds also blocked the *activation* of by cycloheximide , double stranded RNA , calcium ionophore , [TNF-alpha] , active phorbol ester , interleukin-1 , lipopolysaccharide and lectin . Positive_regulation TNF RELA 20692239 2312038 We also observed that hCMEC/D3 cells exhibit functional expression of alternative cytokine signal transduction pathways ( i.e . [TNF-alpha] mediated *activation* of ) . Positive_regulation TNF RELA 20729202 2335712 Synergistic *activation* of by bacterial chemoattractant and [TNF{alpha] } is mediated by p38 MAPK dependent RelA acetylation . Positive_regulation TNF RELA 21138578 2355926 Tetra-O-methyl nordihydroguaiaretic acid ( Terameprocol ) *inhibits* the NF-?B dependent transcription of [TNF-a] and MCP-1/CCL2 genes by preventing from binding its cognate sites on DNA . Positive_regulation TNF RELA 21283748 2387860 Here we report that human monocytes treated with SEA , SEB , or anti-MHC class II monoclonal antibodies up regulated MyD88 expression , induced *activation* of , and increased expression of IL-1R1 accessory protein , [TNF-a] and IL-1ß . Positive_regulation TNF RELA 21502320 2434837 The interferon-gamma induced GTPase , mGBP-2 , *inhibits* [tumor necrosis factor alpha (TNF-alpha)] induction of matrix metalloproteinase-9 (MMP-9) by inhibiting and Rac protein . Positive_regulation TNF RELA 22339724 2560750 Results indicate that these Hb solutions have different effects on stabilization and nuclear translocation of hypoxia-inducible factor (HIF)-1 alpha , induction of the erythropoietin (EPO) gene , *activation* of , and expression of the anti-erythropoietic [agents-tumor necrosis factor-alpha] and transforming growth factor-beta 1 . Positive_regulation TNF RELA 2279003 147438 Additionally , our data show that both dsRNA and LPS , as well as [TNF-alpha] itself , rapidly *induce* , a DNA binding protein implicated in regulation of gene expression . Positive_regulation TNF RELA 23603904 2795199 [Tumor necrosis factor a (TNFa)] *induced* rapid and complete sNix nucleoplasmic translocation concomitant with nuclear translocation of the subunit of NF?B . Positive_regulation TNF RELA 23734186 2796951 This increased secretion of [TNF-alpha] and IL-6 and *activation* of , ERK , and JNK was significantly inhibited by the addition of either mannan or mannose . Positive_regulation TNF RELA 7544915 318436 TRAF2 mediated *activation* of by [TNF] receptor 2 and CD40 . Positive_regulation TNF RELA 7578992 333411 Since induction of AP-1 , IRF-1 and IRF-2 as well as NF-GMa proceeds through translational event , the posttranslational [TNF/LT-driven] *activation* of remains the only cellular event identified so far that serves as a direct target in their signaling cascade . Positive_regulation TNF RELA 7622526 315878 Electrophoretic mobility shift assays demonstrated that *activation* of by L-NMA , ox-LDL , and [TNF alpha] was attenuated by GSNO and SNP , but not by glutathione or cGMP analogues . Positive_regulation TNF RELA 7635431 317121 Using primary cultures of rat Kupffer cells the *role* of and activator protein 1 (AP-1) in the expression of the [tumor necrosis factor-alpha (TNF-alpha)] gene by lipopolysaccharide (LPS) was investigated . Positive_regulation TNF RELA 7636259 317442 Our studies indicate that MV , [TNF-alpha] , or PIPC *induces* ( p50 and p65 subunits ) binding to positive regulatory domain II in the glioma cell line . Positive_regulation TNF RELA 7681592 214297 Transcriptional activation of the HIV long terminal repeat and subsequent increase in virus production are linked to [TNF] *activation* of the cellular transcription factor . Positive_regulation TNF RELA 7737374 305530 [TNF] *induced* the activation of a nuclear transcriptional factor , , equally in both young and senescent cells , which indicates the lack of a defect in the early events of TNF signal transduction in senescent fibroblasts . Positive_regulation TNF RELA 7848678 286667 Our results suggest that [TNF-alpha] stimulation of HIV-1 gene expression in primary cultures of human fetal glial cells is *mediated* by an increase in binding of ( p50/p65 ) to the HIV-1 LTR . Positive_regulation TNF RELA 7913275 262072 HIV-1 expression was activated from J delta K cells by treatment with phorbol myristate acetate ( PMA ) , sodium butyrate ( NaB ) , or hexamethylene bisacetamide ( HMBA ) , but not tumor necrosis factor alpha (TNF-alpha) , confirming the *role* of in mediating [TNF-alpha] induction of HIV transcription . Positive_regulation TNF RELA 7964161 279449 However , our recent study showed that the activation is *induced* by [IL-1/TNF] in fibroblasts from patients with type A Niemann-Pick disease , with acid SMase deficiency . Positive_regulation TNF RELA 7964161 279457 This finding implies that acid SMase activity is not essential for the *activation* of by [IL-1/TNF] at least in fibroblasts . Positive_regulation TNF RELA 8043432 266858 Here we have used an electrophoretic mobility shift assay to show that [TNF] *induced* in malignant cells isolated from 3/3 HCL and 15/15 B-CLL patients . Positive_regulation TNF RELA 8051093 267598 In HeLa cells , [tumor necrosis factor alpha (TNF-alpha)] *induced* activity . Positive_regulation TNF RELA 8074713 270566 In human astrocytoma and neuroblastoma cell lines [tumour necrosis factor alpha (TNF alpha)] and interleukin 1 beta (IL-1 beta) *induced* and an additional KB-specific protein of approximately 80 K to bind the HIV-1 enhancer . Positive_regulation TNF RELA 8076691 270635 Bcl-2 protects from oxidative damage and apoptotic cell death without interfering with *activation* of by [TNF] . Positive_regulation TNF RELA 8076691 270639 However , Bcl-2 had no effect on the *activation* of by [TNF] , even though it protected cells from TNF induced apoptosis . Positive_regulation TNF RELA 8132572 251556 Increasing ceramide levels by the addition of short chain ceramides or the use of a glucosylceramide synthase inhibitor can be dissociated from *activation* of by [TNF-alpha] . Positive_regulation TNF RELA 8152812 253060 *Activation* of multiple DNA binding complexes by [tumor necrosis factor] . Positive_regulation TNF RELA 8207213 261388 Recent studies demonstrate that the sphingomyelinase-ceramide pathway plays a potential role in the *activation* of by [TNF-alpha] . Positive_regulation TNF RELA 8207213 261392 This data suggests that although ceramide and 1,2-diacylglycerol ( DAG ) pathways may contribute to [TNF-alpha] *activation* of , impedance of these pathways does not block TNF-alpha from activating NF-kappa B nor induction of the functional activation of the NF-kappa B responsive reporter construct , HCMV . Positive_regulation TNF RELA 8264646 247039 In Hs294T cells , gel shift analyses indicate that IL-1 and [TNF alpha] *induce* complex formation ; Positive_regulation TNF RELA 8376408 229928 As shown previously , [TNF] ( 1 nM ) *induced* a marked increase in nuclear binding in human leukemia ( HL-60 ) cells within 5 min , and elevated binding was detected for as long as 1 h. Addition of a maximally effective concentration of sphingomyelinase , 0.1 units . ml-1 , induced a 50 % reduction in sphingomyelin content by 5 min from a basal level of 560 pmol.10 ( 6 ) cells-1 and a quantitative increase in ceramide levels from 89 pmol.10 ( 6 ) cells-1 . Positive_regulation TNF RELA 8555009 340105 TPCK , a I kappa-B alpha protease inhibitor , was able to virtually abolish UV-induced TNF release , indicating that UV-induced [TNF] release *requires* activation . Positive_regulation TNF RELA 8598494 350746 We demonstrate that IL-1 and [TNF] *induce* in T cell clones , whereas TCR induced NF-Kappa B activation in Th1 cells is delayed and may be longer in duration . Positive_regulation TNF RELA 8612692 353279 [TNFalpha] *induces* a rapid and transient activation of in WEHI 164 cells which is followed by a second , long lasting phase in which the amount of NF-kappaB complex in the nucleus remains at about 50 % of maximum . Positive_regulation TNF RELA 8612692 353283 Calphostin C , on the other hand , can block the *activation* of by [TNFalpha] , also blocking its proteolytic degradation . Positive_regulation TNF RELA 8626413 355700 Furthermore , *activation* of by [tumor necrosis factor-alpha] also results in repression of PR , while PR is able to repress tumor necrosis factor-alpha induced NF-kappaB activity . Positive_regulation TNF RELA 8798400 381445 These results indicate that TNF-alpha induced [TNF-alpha] gene expression in astrocytes *involves* p50 and p65 proteins binding to downstream NF-kappaB sites and concomitant modulation of the chromatin structure . Positive_regulation TNF RELA 8799159 381939 Our results show that the *activation* of by [tumor necrosis factor (TNF)] is completely blocked by CAPE in a dose- and time dependent manner . Positive_regulation TNF RELA 8805640 382274 Overall , our results clearly demonstrate that the *activation* of and cytotoxicity by [TNF] is differentially regulated through the p60 receptor . Positive_regulation TNF RELA 8822344 384837 HTLV-I tax protein and [TNF-alpha] *induced* activation of in apoptotic MC3T3-E1 cells . Positive_regulation TNF RELA 8832978 385881 Our data suggest that TNF-alpha induces expression of proinflammatory cytokines such as IL-8 and MCP-1 through generation of reactive oxygen intermediates and subsequent activation of NF-kappa B in human synovial cells , and the antioxidants may inhibit , at least in part , the *activation* of by [TNF-alpha] . Positive_regulation TNF RELA 8864119 388931 The *activation* of the transcription factor by [tumor necrosis factor (TNF)] , ionizing radiation , or daunorubicin ( a cancer chemotherapeutic compound ) , was found to protect from cell killing . Positive_regulation TNF RELA 8892903 392256 Nevertheless , the simian EBV LMP1s retain most functions in common with EBV LMP1 , including the ability to induce activity in human cells , to bind the tumor necrosis factor associated factor 3 ( TRAF3 ) in vitro , and to *induce* expression of [tumor necrosis factor-responsive] genes , such as ICAM1 , in human B lymphocytes . Positive_regulation TNF RELA 8900181 393436 Synergistic activation of interleukin-8 gene transcription by all-trans-retinoic acid and [tumor necrosis factor-alpha] *involves* the transcription factor . Positive_regulation TNF RELA 8940176 399122 [Tumor necrosis factor-alpha] and interferon-gamma *induced* ( p50/p65 ) and STAT-1 , respectively , as assessed by gel shift assays . Positive_regulation TNF RELA 9042860 416131 We also show that *activation* of by [TNFalpha] depends on CDC42 and RhoA , but not Rac-1 proteins , because this activity is drastically inhibited by their respective dominant negative mutants . Positive_regulation TNF RELA 9060638 417784 Under the same conditions , Ad infection did not inhibit TNF induced phosphorylation of cPLA2 or [TNF] *activation* of . Positive_regulation TNF RELA 9065470 418209 The activation of NF-kappaB by fMLF appeared to be cell-specific and different from the *activation* of by [tumor necrosis factor-alpha (TNFalpha)] . Positive_regulation TNF RELA 9079634 420543 *Role* of in [tumor necrosis factor-alpha] and interleukin-1beta regulation . Positive_regulation TNF RELA 9160673 431735 The stimulatory effect of PTX on the immediate early ( IE ) enhancer/promoter was mediated via CREB/ ATF , a eukaryotic transcription factor that binds to the 19 bp sequence motif in the enhancer region , while [TNF alpha] stimulation was *mediated* by activation of the transcription factor and its binding to the 18 bp sequence motif in the enhancer . Positive_regulation TNF RELA 9224415 442944 Inhibition of activity by these agents also *prevented* TNF mRNA expression and [TNF] production induced by LPS . Positive_regulation TNF RELA 9227470 443239 A redox-sensitive nuclear factor , , *induces* transcription of [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-6 (IL-6) in macrophages . Positive_regulation TNF RELA 9244310 446239 Activation of the transcription factor NF-kappaB by [tumor necrosis factor (TNF)] and interleukin-1 (IL-1) *requires* the . Positive_regulation TNF RELA 9275204 450673 The NF-kappaB inducing kinase (NIK) associates with TRAF2 and mediates [TNF] *activation* of . Positive_regulation TNF RELA 9277450 450777 Moreover , the inhibitors *blocked* SP-A dependent increases in [tumor necrosis factor-alpha] mRNA levels . Positive_regulation TNF RELA 9299419 453454 Hence , it was of interest to investigate the role of endogenous glutathione status in [TNF alpha] *induced* activation in skeletal muscle derived cells . Positive_regulation TNF RELA 9299419 453456 Results from GSSG reductase inhibited cells suggest that GSSG may participate in , but is not required for , [TNF alpha] *induced* activation . Positive_regulation TNF RELA 9325328 456918 Lipid peroxidation is involved in the *activation* of by [tumor necrosis factor] but not interleukin-1 in the human endothelial cell line ECV304 . Positive_regulation TNF RELA 9332715 457647 The oxidative stress responsive transcription factor consists of a p50 ( 50 kDa ) and p65/RelA ( 65 kDa ) component and can be *activated* in vitro by [TNF alpha] , IL1 beta , hydrogen peroxide and oxygen radicals . Positive_regulation TNF RELA 9343439 459031 However , since *activation* of by [TNF-alpha] is often transient and would not activate long-term kappaB dependent transcription effectively , we explored the effects of IFN-gamma on TNF-alpha induced NF-kappaB activity . Positive_regulation TNF RELA 9346915 459566 In this cell line ( EL4D6/76 ) , [tumor necrosis factor] *induced* ligand/receptor internalization , nuclear translocation , IL-2 production , and the activation of neutral (N)-SMase and acid ( A ) -SMase . Positive_regulation TNF RELA 9366558 466090 Transcriptional control of the [TNF alpha] gene is *regulated* by the . Positive_regulation TNF RELA 9374527 465137 Despite *activation* of by [TNF] , this transcription factor was not required for TNF induced transcription of gamma-GCS-HS as revealed by deletion constructs of the gamma-GCS-HS promoter subcloned in a chloramphenicol acetyltransferase reporter vector and transfected into HepG2 cells . Positive_regulation TNF RELA 9383399 345238 Our data show that one ROI species , H2O2 acts as a messenger in the [TNF-] and okadaic acid induced post-translational *activation* of . Positive_regulation TNF RELA 9388244 466790 *Activation* of by [TNF-alpha] occurred within 15 min and coincided with rapid degradation of IkappaBalpha . Positive_regulation TNF RELA 9417872 472285 Expression of bcl-2 did not impose a block to , or potentiate , [TNF-alpha] signaling of I kappa B alpha degradation , nuclear import of the RelA p65 , or *transactivation* . Positive_regulation TNF RELA 9418855 480455 *Activation* of by [TNF] and IL-1 is initiated by the phosphorylation of the inhibitory subunit , IkappaB , which targets IkappaB for degradation and leads to the release of active NF-kappaB . Positive_regulation TNF RELA 9439980 475071 IL1 alpha and [TNF-alpha] rapidly *induced* both AP-1 and DNA binding activities in +/+ ( - ) 1.LDA11 stromal cells . Positive_regulation TNF RELA 9454839 484403 Furthermore , unlike TNF-alpha treatment , NGF treatment did not significantly activate JNK , although both [TNF-alpha] and NGF *induced* nuclear translocation of . Positive_regulation TNF RELA 9486215 488323 In the present study , electrophoretic mobility shift assays ( EM-SAs ) and pyrrolidine dithiocarbamate ( PDTC ) , an inhibitor of NF-kappa B activation , were utilized to determine the *role* of activation in TPA and [TNF-alpha] inhibition of the surfactant proteins in NCI-H441 cells . Positive_regulation TNF RELA 9565556 500911 Interestingly , both the potent physiological inducer of NF-kappaB [TNFalpha] as well as endoplasmic reticulum overload can *induce* via a PDTC sensitive pathway . Positive_regulation TNF RELA 9636658 513391 The role of DNA-PK , a protein kinase involved in the response to DNA damage , in the *activation* of by IR and [TNF alpha] was examined . Positive_regulation TNF RELA 9636658 513418 These results indicate that DNA-PK participates in the *activation* of by IR but not by [TNF alpha] . Positive_regulation TNF RELA 9642107 514180 At 150 microM LA-Plus , but not LA , inhibited [TNFalpha] *induced* activation . Positive_regulation TNF RELA 9683180 521412 Moreover , these findings support the hypothesis that Kupffer cells play a pivotal role in peroxisome proliferator induced hepatocyte proliferation through rapid activation and subsequent *induction* of [TNF alpha] production . Positive_regulation TNF RELA 9691914 523158 [TNF-alpha] induction of ICAM-1 expression is *mediated* by the transcription factor and can be inhibited by blocking I kappa B alpha degradation . Positive_regulation TNF RELA 9718198 528181 These results suggest that the rapid *activation* of by [TNF-alpha] is mainly due to the nuclear translocation of NF-kappaB pre existing in cytosol , and that the subsequent increase in the expression of p50 and p65 may result in the persistent activation of NF-kappaB during TNF-alpha stimulation . Positive_regulation TNF RELA 9718198 528200 These results suggest that the *activation* of by [TNF-alpha] may play an important role in the production of cytokines and cell adhesion molecules from osteoblasts , leading to the promotion of bone resorption and inflammation . Positive_regulation TNF RELA 9724317 529417 In saline pretreated rats , LPS caused a rapid decrease in myocardial IkappaB-alpha protein levels , *activation* of , and increased [TNF-alpha] production . Positive_regulation TNF RELA 9728048 530026 These findings indicate that [TNF-alpha] *induces* activation and the resultant E-selectin gene expression by a pathway that involves formation of ROS and that E-selectin expression can be inhibited by the antioxidant action of NAC or PDTC . Positive_regulation TNF RELA 9794408 542963 Fc epsilonRI mediated *induction* of [TNF-alpha] gene expression in the RBL-2H3 mast cell line : regulation by a novel nuclear binding complex . Positive_regulation TNF RELA 9802878 544027 In the present study , which uses mice with genetic deletions of the proteins of NF-kappaB complex , we provide data demonstrating that increased expression of the p50 subunit of directly *results* in the downregulation of LPS induced [TNF] production . Positive_regulation TNF RELA 9830008 551248 H2O2 and [tumor necrosis factor-alpha] *induce* differential binding of the redox-responsive transcription factors AP-1 and to the interleukin-8 promoter in endothelial and epithelial cells . Positive_regulation TNF RELA 9830008 551281 [TNFalpha] *induced* complexes containing Rel A ( p65 ) . Positive_regulation TNF RELA 9916895 559056 We determined that binding sites for both ( -186 bp region ) and C/EBP ( -198 bp region ) are *involved* in [TNF-alpha] and IL-1beta mediated ICAM-1 upregulation . Positive_regulation TNF RELA 9990294 597306 Using antisense oligonucleotides , we confirmed that the [TNF-alpha-stimulation] of HA synthesis by MRC-5 cells is *dependent* on the activation of the . Positive_regulation TNF RELB 12709443 1100443 Moreover , we show that , p50 , and p100 can associate in the same complex and that [TNF-alpha] but not LTbeta signaling *increases* the association of p100 with RelB/p50 dimers in the nucleus , leading to the specific inhibition of RelB DNA binding . Positive_regulation TNF RELB 15265917 1275627 Finally , we demonstrated that inhibition of endogenous by RNA interference severely *reduced* the [TNF] responsiveness of our pIgR derived reporter gene . Positive_regulation TNF RELB 17008396 1674095 However , [TNF] *induced* a NFkappaB DNA binding complex in p50 null MEC nuclear extracts . Positive_regulation TNF RELB 19901031 2188917 Moreover , we found that forced expression of in responsive cells *induced* repressive nucleosome positioning and silenced [TNFalpha] transcription , demonstrating the plasticity of nucleosome remodeling and its dependence on RelB . Positive_regulation TNF RELB 20686703 2299246 We conclude that *regulates* [TNFalpha] cytokine synthesis by competitive interference binding with RelA , which leads to downregulation of TNFalpha production . Positive_regulation TNF RELB 23394901 2755039 *regulates* [TNF] production in LPS stimulated dendritic cells and macrophages . Positive_regulation TNF RENBP 10652049 662574 The addition of exogenous TGF-beta1 ( 0.1 to 10 ng/mL ) decreased *induced* [TNF-alpha] production and increased IL-1Ra production in a dose dependent fashion . Positive_regulation TNF RENBP 11788787 892040 B ) LZ stimulated the uptake and degradation of ( 125 ) I-labeled AGE-BSA and ( 25 ) I-human serum AGE by Mf , while suppressing *induced* [TNFalpha] and IGF-I production . Positive_regulation TNF RENBP 14991464 1215464 Furthermore , the effects of four xanthine derivatives on *induced* [TNF-alpha] release were investigated . Positive_regulation TNF RENBP 14991464 1215467 The xanthine derivatives pentoxyphylline and propentophylline attenuate *induced* [TNF-alpha] release in a dose dependent manner . Positive_regulation TNF RENBP 14991464 1215468 The inhibition of the *induced* [TNF-alpha] release by pentoxyphylline and propentophylline provides interesting pharmacological strategies for diseases with local neuroinflammation such as Alzheimer 's disease . Positive_regulation TNF RENBP 15182127 1255712 However , in the presence of 1 or 10 ng/ml of endotoxin , *augmented* the production of IL-1 and [TNF] above that induced by endotoxin alone . Positive_regulation TNF RENBP 16450750 1521997 Both AGE modified beta2m and significantly *increased* [TNF-alpha] and IL-1beta secretion by human PMO in a dose dependent manner ( 50-200 microg/ml ) . Positive_regulation TNF RENBP 17434489 1729014 We also observed that NF-kappaB is involved in *induced* [TNF-alpha] . Positive_regulation TNF RENBP 1762301 174671 These findings suggest that may be *involved* in the production of [TNF] and IL-1 from M phi . Positive_regulation TNF RENBP 19445683 2107135 In the present study , we examined the effect of epigallocatechin-3-gallate ( EGCG ) on *induced* activation and production of [TNFalpha] and MMP-13 in human OA chondrocytes . Positive_regulation TNF RENBP 19445683 2107137 EGCG significantly decreased *stimulated* gene expression and production of [TNFalpha] and MMP-13 in human chondrocytes . Positive_regulation TNF RENBP 19445683 2107139 The inhibitory effect of EGCG on the *induced* expression of [TNFalpha] and MMP-13 was mediated at least in part via suppression of p38-MAPK and JNK activation . Positive_regulation TNF RENBP 19857486 2196818 In a previous study , we found that glyceraldehyde derived ( AGE-2 ) and glycolaldehyde derived AGE ( AGE-3 ) at 100 microg/ml *induced* the expressions of ICAM-1 and CD40 on monocytes and the production of interferon (IFN)-gamma and [tumor necrosis factor (TNF)-alpha] in human peripheral blood mononuclear cells . Positive_regulation TNF RENBP 20540146 2295671 This study tested the pure compounds apigenin and diosmetin as well as extracts from silymarin , uva ursi ( bearberry ) and green olive leaf for their ability to attenuate *induced* NO and [TNF-alpha] production . Positive_regulation TNF RENBP 20583309 2285612 significantly *increased* [tumour necrosis factor-alpha (TNF-alpha)] , a major pro-inflammatory cytokine . Positive_regulation TNF RENBP 20718752 2306761 In addition , CIP inhibited AGE-2- and *induced* expressions of ICAM-1 , B7.1 , B7.2 and CD40 in monocytes , the production of [TNF-alpha] and IFN-gamma and lymphocyte proliferation in PBMC . Positive_regulation TNF RENBP 22944044 2726558 Antioxidant TEMPOL almost completely inhibited *induced* [TNF-a] secretion , whereas NF-?B inhibitor PDTC partly suppressed AGE3 induced 8-OHdG production . Positive_regulation TNF RENBP 23183190 2740886 In the present study , we examined the effect of curcumin , a pharmacologically safe phytochemical agent , on *induced* [tumor necrosis factor-a (TNF-a)] and matrix metalloproteinase-13 (MMP-13) in rabbit chondrocytes . Positive_regulation TNF RENBP 23183190 2740888 Curcumin significantly decreased *stimulated* [TNF-a] and MMP-13 mRNA and suppressed the NF-?B activation via inhibition of ?Ba ( I-?Ba ) phosphorylation , I-?Ba degradation and p65 nuclear translocation . Positive_regulation TNF RENBP 23195897 566763 Consequently , *stimulated* the proliferation of mouse spleen cells and the release of cytokines , such as IL-2 , [TNF-alpha] and IFN-gamma , increased NK activities , and enhanced phagocytosis of peritoneal macrophages . Positive_regulation TNF RETN 15737463 1378596 Stimulated expression in white adipose of rats with bile duct ligation induced liver cirrhosis : relationship to cirrhotic hyperinsulinemia and *increased* [tumor necrosis factor-alpha] . Positive_regulation TNF RETN 17525801 1751405 We also report that centrally mediated mechanisms partially control *induced* expression of [TNF-alpha] , IL-6 , and SOCS-3 in the liver . Positive_regulation TNF RETN 23765438 2882292 The adipocytokine *stimulates* the production of proinflammatory cytokines [TNF-a] and IL-6 in pancreatic acinar cells via NF-?B activation . Positive_regulation TNF RETN 23765438 2882294 exhibits some cytotoxic activity in rat pancreatic acinar AR42J cells and *stimulates* proinflammatory cytokine [TNF-a] and IL-6 production via NF-?B activation . Positive_regulation TNF REV1 24040434 2842692 and HKBM or *induced* secretion of IL-1ß , IL-2 , GM-CSF , IFN-? , and [TNF-a] . Positive_regulation TNF RFX1 12558194 1029108 Treatment of animals with CLX or RFX did not alter the content of pro-inflammatory cytokines IL-1beta or TNF-alpha in the pleural exudate , but CLX reduced IL-1beta levels in the rat paw tissue and *increased* [TNF-alpha] in this tissue . Positive_regulation TNF RGN 15578574 1368503 The effect of parathyroid hormone ( 10 ( -7 ) M ) , 1,25-dihydroxyvitamin D ( 3 ) ( 10 ( -7 ) M ) , prostaglandin E ( 2 ) ( 10 ( -5 ) M ) , or [tumor necrosis factor-alpha] ( 10 ng/ml ) in increasing osteoclast-like cell formation was significantly enhanced in the *presence* of ( 10 ( -8 ) M ) . Positive_regulation TNF RGS1 19877080 2160737 was significantly *induced* either by [tumor necrosis factor alpha (TNFalpha)] or by interleukin-17 (IL-17) . Positive_regulation TNF RGS16 14566449 1165123 Interleukin-1beta mediates endotoxin- and [tumor necrosis factor] alpha *induced* protein expression in cultured cardiac myocytes . Positive_regulation TNF RGS16 14566449 1165126 IL-1beta ( 1.75-fold ) and [TNFalpha] ( 1.62-fold ) but not IL-6 and IFNgamma *induced* protein expression . Positive_regulation TNF RHBDF2 22246777 2538279 We report that ( RHBDF2 ) , a proteolytically inactive member of the rhomboid family , is *required* for [TNF] release in mice . Positive_regulation TNF RHO 17762807 1790196 Furthermore , it is thought that is *involved* in [TNF-alpha] and interleukin (IL) production in the central nervous system , and the production was inhibited by administering Rho kinase inhibitor in the central nervous system . Positive_regulation TNF RHO 20593289 2296393 Moreover , these findings show that signalling *regulates* [TNF-alpha] and CXC chemokine formation as well as lipid peroxidation in the reperfused colon . Positive_regulation TNF RHO 24272709 2893130 Inhibition of the microglial activity also *blocked* the AII induced increase in [TNF-a] levels . Positive_regulation TNF RHOA 12730857 1086814 In vitro , activation of alone was *sufficient* to induce [tumor necrosis factor] production . Positive_regulation TNF RHOA 17059425 1683922 Zoledronate reduced Ras prenylation , Ras and translocation to the membrane , and sustained ERK1/2 phosphorylation and [tumor necrosis factor (TNF)] *induced* JNK phosphorylation . Positive_regulation TNF RHOA 17476691 1772263 [TNF-alpha] rapidly *induced* activation and myosin light chain phosphorylation , but caused only small changes to cortical F-actin , without significantly increasing paracellular permeability up to 30 min after stimulation . Positive_regulation TNF RHOA 17660390 1799067 [TNF-alpha] *induced* NF-kappaB and activation and upregulation of adhesion molecules ICAM-1 and VCAM-1 , increased expression of monocyte chemoattractant protein , enhanced transendothelial migration of monocytes , and augmented monocyte-endothelial adhesion . Positive_regulation TNF RHOA 18097057 1847505 [TNF-alpha] *induced* a time dependent activation of and Rho kinase in these ECs . Positive_regulation TNF RHOA 23389627 2759180 Taken together , our findings can explain the mechanisms leading to hierarchical *activation* of Rac and by [TNF-a] through a single GEF . Positive_regulation TNF RIPK1 19927158 2203739 To determine the *role* of in [TNF/IAP] antagonist induced death , we compared wild type ( WT ) and RIPK1 ( -/- ) mouse embryonic fibroblasts ( MEFs ) treated with these compounds . Positive_regulation TNF RIPK1 23328672 2733657 is therefore not *essential* for [TNF] to activate RIPK3 to induce necroptosis nor for the formation of a functional ripoptosome/necrosome . Positive_regulation TNF RIPK1 24497535 2928359 The loss of or RIPK3 , but not the RIPK3 substrate mixed lineage kinase domain-like protein , *attenuated* [TNF] secretion and thereby prevented apoptotic cell death and not necrosis . Positive_regulation TNF RIPK2 18028797 1827929 Blocking of could *attenuate* LPS induced [TNFalpha] and HMGB1 production . Positive_regulation TNF RIPK3 24497535 2928360 The loss of RIPK1 or , but not the RIPK3 substrate mixed lineage kinase domain-like protein , *attenuated* [TNF] secretion and thereby prevented apoptotic cell death and not necrosis . Positive_regulation TNF RNASE3 20089176 2206060 In conclusion , our results have demonstrated that *increased* [TNF-alpha] production in BEAS-2B cells and triggered apoptosis by caspase-8 activation through mitochondria independent pathway . Positive_regulation TNF RNASE3 20633653 2310400 Both NO and [TNF-alpha] productions *induced* by were significantly blocked by a JNK inhibitor . Positive_regulation TNF RNF103 18768892 1957202 Consistently , Nod2-null macrophages tolerant to LPS and MDP showed enhanced production of [TNF-alpha] and IL-6 as well as increased NF-kappaB and MAPK activation in *response* to the dipeptide , the Nod1 agonist . Positive_regulation TNF RNF19A 12220570 986958 Gö6976 *inhibits* LPS induced microglial [TNFalpha] release by suppressing MAP kinase activation . Positive_regulation TNF RNF19A 16622205 1551606 extracellular signal regulated kinase 1/2 [ERK1/2 ] and ) and *induces* [tumor necrosis factor alpha (TNF-alpha)] and interleukin 6 (IL-6) in human monocytes . Positive_regulation TNF RPL17 23610399 2804652 We observed that high levels of PD-1 expression were required to inhibit macrophage inflammatory protein 1 beta production , lower levels were required to block cytotoxicity and IFN-? production , and very low levels of expression could *inhibit* [TNF-a] and IL-2 production as well as T-cell expansion . Positive_regulation TNF RPL18 24611904 2933913 On average , *induced* [TNF] production in 25 % of monocytes from healthy donors or female carriers , while fewer than 6 % of monocytes responded in affected patients . Positive_regulation TNF RPS23 18458151 1927014 Importantly , blocking CD36 did not affect [TNF] release *induced* by ( palmitoyloxy ) - ( 2R , S ) -propyl ] - ( R ) -cysteinyl-seryl- ( lysyl ) 3-lysine or LPS . Positive_regulation TNF RPS6KA3 21665267 2451163 In RAW264.7 cells and DBA/2 mice , and ctDNA-N-CLs significantly *induced* [TNF-a] and IL-6 production compared to free ctDNA . Positive_regulation TNF RPS6KA5 17074860 1675558 The repression of expression with small interfering RNA *results* in reduced RelA phosphorylation and a significant decrease in the production of [TNF-alpha] in response to B. burgdorferi lysates . Positive_regulation TNF RPS6KA5 17913704 1830212 Together with cPLA(2) redistribution and AA release , [TNFalpha] *induced* a time dependent phosphorylation of ERK , , PKCzeta , CaMKII , and phospholamban on the threonine 17 residue . Positive_regulation TNF RPS6KA5 20303596 2230493 Furthermore , inhibitors of p38 and , but not PKA , completely *blocked* the production of IL-10 and [TNFalpha] in LPS stimulated macrophages . Positive_regulation TNF RPTOR 22351078 2561122 The aim of this study was to investigate the *role* of in myocardial [TNF-a] expression during endotoxemia . Positive_regulation TNF RUNX2 15516323 1328538 [TNF-alpha] ( 10ng/ml ) increased BSP , IL-6 and COX-2 mRNA levels after 3h , reaching maximal levels at 12 h . mRNA levels *increased* after 3 h , but decreased by 24 h. Osterix , cathepsin B , cathepsin L and TIMP-1 mRNA levels did not change after stimulation with TNF-alpha . Positive_regulation TNF RUNX2 21658981 2546514 induced both mechanical allodynia and thermal hyperalgesia , and *increased* the expression of [TNF-a] , IL-1ß , IL-6 and NF-?B . Positive_regulation TNF S100A11 16339570 1491683 CXCL8 and [TNF-alpha] *induced* expression and release in cultured chondrocytes . Positive_regulation TNF S100A12 11446746 835440 We recently found that *induces* IL-6 and [TNF-alpha] in long-term bone marrow cultures and that IL-6 and TNF-alpha also inhibit IL-7 responses . Positive_regulation TNF S100A12 11446746 835445 In contrast , did not *induce* [TNF-alpha] in BMDMs . Positive_regulation TNF S100A12 11792459 901888 We found that substance P ( SP ) and ( 0.3-1 microM ) *increased* , in a concentration dependent manner , the basal secretion of interleukin-1 beta (IL-1 beta) , interleukin-6 (IL-6) , and [tumor necrosis factor alpha (TNF alpha)] from cultured lymphocyte enriched mononuclear cells isolated from human peripheral blood . Positive_regulation TNF S100A12 11792459 901891 SP and ( 0.1 microM ) synergistically *increased* basal [TNF alpha] secretion . Positive_regulation TNF S100A12 14636837 1171331 Mouse peritoneal macrophages were infected with herpes simplex virus type-1 ( HSV-1 ) , or remained unstimulated , and cytokine assays were performed after 12 h . IL-1 beta and [TNF] secretion by unstimulated macrophages have been significantly increased in the *presence* of SP and . Positive_regulation TNF S100A12 17046032 1683783 SB366791 , ( 8-37 ) and indomethacin ( IM ) *enhanced* increases in spinal cord tissue [TNF] levels at 2h after trauma and exacerbated motor disturbances . Positive_regulation TNF S100A12 19194162 2033605 Pretreatment with capsazepine , ( 8-37 ) , indomethacin , and denervation of primary sensory nerves significantly *increased* blood urea nitrogen and serum creatinine levels , renal vascular permeability , renal tissue levels of myeloperoxidase activity , cytokine induced neutrophil chemoattractant , and [tumor necrosis factor-alpha] , and decreased renal tissue blood flow . Positive_regulation TNF S100A12 23638054 2779320 did not *stimulate* IL-6 , IL-8 , IL-1ß or [TNF-a] production by human peripheral blood mononuclear cells but low amounts consistently reduced cytokine mRNA and protein levels induced by serum amyloid A , by ~49 % and ~46 % , respectively . Positive_regulation TNF S100A12 23958840 2850328 1 ) that CGRP stimulates keratinocyte expression of CGRP and its receptor complex , 2 ) that SP and *stimulate* IL-6 and [TNF-a] secretion in keratinocytes , 3 ) that SP activated all three MAPK families and the NF?B transcriptional signaling pathway in keratinocytes , and 4 ) that SP and CGRP stimulated inflammatory mediator production in keratinocytes is dependent on ERK1/2 and JNK activation . Positive_regulation TNF S100A12 9417811 472227 Since CGRP was shown to inhibit TNF-alpha production by T cells and stimulate IL-6 expression by fibroblasts , this study was designed to investigate whether *regulated* [TNF-alpha] and IL-6 production by osteoblasts . Positive_regulation TNF S100A12 9548453 477669 Fifth , *induced* mast cells to release [TNF-alpha] . Positive_regulation TNF S100A4 21712367 2483823 Although S100A4 did not affect myocytes , stimulation of PBMCs with significantly *induced* the expression and synthesis of [TNF-a] , IL-1ß and IL-6 , but not of IFN-a . Positive_regulation TNF S100A4 24643522 2942797 Stimulation of PBMCs with significantly *up-regulated* IL-1ß , IL-6 and [TNF-a] production compared with unstimulated cells ( P < 0.001 ) . Positive_regulation TNF S100A6 18753141 1980030 These results demonstrate that is *induced* by [tumor necrosis factor-alpha] via an NF-kappaB dependent mechanism , serving a role in homeostasis to limit tumor necrosis factor-alpha induced apoptosis by regulating p53 phosphorylation . Positive_regulation TNF S100B 18599158 2208585 We show here that : ( 1 ) S100B also stimulates AP-1 transcriptional activity in microglia via RAGE dependent activation of JNK; (2) *upregulates* IL-1beta and [TNF-alpha] expression in microglia via RAGE engagement ; Positive_regulation TNF S100B 18599158 2208590 and ( 3 ) *induced* upregulation of COX-2 , IL-1beta and [TNF-alpha] expression requires the concurrent activation of NF-kappaB and AP-1 . Positive_regulation TNF S100B 23755753 2797804 Soluble RAGE ( sRAGE ) reduced *dependent* secretion of [TNF-alpha] but did not decrease S100B dependent secretion of IL-6 . Positive_regulation TNF S11 12812139 1103019 In experimental studies we found that P. carinii Major ( MSG ) *induced* IL-8 and [tumor necrosis factor-alpha] secretion from human monocytes and an alveolar epithelial cell line ( A549 ) . Positive_regulation TNF S11 7681399 214247 Moreover , [TNF] *induced* a moderate increase of CD14 expression , used as a phenotypic marker of monocyte/macrophage differentiation . Positive_regulation TNF S12 12812139 1103020 In experimental studies we found that P. carinii Major ( MSG ) *induced* IL-8 and [tumor necrosis factor-alpha] secretion from human monocytes and an alveolar epithelial cell line ( A549 ) . Positive_regulation TNF S12 7681399 214248 Moreover , [TNF] *induced* a moderate increase of CD14 expression , used as a phenotypic marker of monocyte/macrophage differentiation . Positive_regulation TNF S7 12812139 1103021 In experimental studies we found that P. carinii Major ( MSG ) *induced* IL-8 and [tumor necrosis factor-alpha] secretion from human monocytes and an alveolar epithelial cell line ( A549 ) . Positive_regulation TNF S7 7681399 214249 Moreover , [TNF] *induced* a moderate increase of CD14 expression , used as a phenotypic marker of monocyte/macrophage differentiation . Positive_regulation TNF SAA1 1424289 202244 ( iv ) [TNF-alpha] in the presence or absence of IL-6 and/or prednisolone did not *induce* the production of or CRP by HepG2 cells . Positive_regulation TNF SAA1 14749357 1226342 [Tumor necrosis factor-alpha] *induces* in mouse granulosa cells . Positive_regulation TNF SAA1 14757367 1205882 Our findings indicate that *stimulates* the rapid expression and release of [TNF-alpha] from cultured human blood neutrophils . Positive_regulation TNF SAA1 14871291 1208141 The [TNF-driven] induction of SAA1 , but not that of SAA2 , can be *enhanced* by GCs in both cell lines , whereas GCs alone can upregulate only in epithelial cells . Positive_regulation TNF SAA1 16483749 1534804 *induced* dose dependent production of [TNF-alpha] and IL-1 beta in HMC-1 cells . Positive_regulation TNF SAA1 16569709 1574725 We found that *stimulated* the production of [tumor necrosis factor (TNF)-alpha] and interleukin (IL)-10 , which are proinflammatory and anti-inflammatory cytokines , respectively , in human monocytes . Positive_regulation TNF SAA1 18571179 2019867 This study examined *induction* of TF and [tumour necrosis factor-alpha (TNF)] in PBMC from patients with CAD and in monocytoid THP-1 cells . Positive_regulation TNF SAA1 18571179 2019869 Unlike CRP , *induced* TF and [TNF] in THP-1 cells . Positive_regulation TNF SAA1 18571179 2019870 *induced* [TNF] was dose-dependently inhibited by HDL . Positive_regulation TNF SAA1 18571179 2019871 Importantly , *induced* [TNF] levels ( ELISA ) were much higher in patients with ACS than SA or controls ( ACS 211+/-41 , SA 108+/-16 , controls 73+/-11 pg/mL , with SAA 250 ng/mL , P=0.001 ACS vs. controls or P=0.013 ACS vs. SA across the dose range ) . Positive_regulation TNF SAA1 18718487 1979881 In previous studies , we demonstrated that *stimulated* the production of [TNF-alpha] , IL-1beta , IL-8 , NO , and ROS by neutrophils and/or mononuclear cells . Positive_regulation TNF SAA1 19223523 2071993 IL-1beta , [TNF-alpha] , and human AT macrophage conditioned medium significantly *induced* secretion ( from 2.6 to 7.6 fold ) in hMADS cells . Positive_regulation TNF SAA1 21953420 2522077 With increased levels , the plasma levels of interleukin-6 and [tumor necrosis factor-a] were significantly *increased* . Positive_regulation TNF SAA1 22076945 2574649 Acute-phase *regulates* [tumor necrosis factor] a and matrix turnover and predicts disease progression in patients with inflammatory arthritis before and after biologic therapy . Positive_regulation TNF SAA1 22241121 2519617 High-density lipoprotein prevents *induced* production of [TNF-a] in THP-1 monocytic cells and peripheral blood mononuclear cells . Positive_regulation TNF SAA1 22241121 2519618 The addition of HDL inhibited the *induced* [TNF-a] release in a dose dependent manner . Positive_regulation TNF SAA1 22241121 2519619 In human peripheral blood mononuclear cells , the inhibitory effect of HDL on [TNF-a] production *induced* by was less pronounced . Positive_regulation TNF SAA1 23942262 2835894 Moreover , *stimulated* [TNF-a] production was prevented by a Toll-like receptor 4 (TLR4) antagonist . Positive_regulation TNF SAA1 2454996 93464 These results indicate that human and CRP are *induced* in Hep 3B cells by products of activated monocytes but not by IL-1 beta , [TNF-alpha] , or some hepatocyte stimulating factor preparations and that a group of heterogeneous mechanisms are involved in the induction of the various human APP . Positive_regulation TNF SAA1 3261378 96043 Exogenous IL-1 and [TNF] *induce* synthesis in vivo and in vitro , while exogenous IL-6 is a far less potent stimulus of in vivo SAA gene expression . Positive_regulation TNF SAA2 12557750 1029078 The Saa1 and promoters are strongly *induced* by IL-6 , with synergistic upregulation of Saa2 , but not of Saa1 , by IL-1 or [TNF] . Positive_regulation TNF SAA2 14749357 1226343 [Tumor necrosis factor-alpha] *induces* in mouse granulosa cells . Positive_regulation TNF SAA2 16569709 1574726 We found that *stimulated* the production of [tumor necrosis factor (TNF)-alpha] and interleukin (IL)-10 , which are proinflammatory and anti-inflammatory cytokines , respectively , in human monocytes . Positive_regulation TNF SAA2 22076945 2574650 Acute-phase *regulates* [tumor necrosis factor] a and matrix turnover and predicts disease progression in patients with inflammatory arthritis before and after biologic therapy . Positive_regulation TNF SAA2 8565321 349120 IL-1 and [tumour necrosis factor (TNF)] *induced* hepatic accumulation of both SAA1 , and SAA3 , while only SAA1 and SAA2 mRNA accumulation was seen after IL-6 stimulation . Positive_regulation TNF SAA3P 23858030 2825203 Although ( 20-86 ) caused a low , but appreciable level of endocytosis in TLR4 , it *induced* the upregulation of both IL-6 and [TNF-a] , but not IFN-ß1 . Positive_regulation TNF SAA3P 8565321 349121 IL-1 and [tumour necrosis factor (TNF)] *induced* hepatic accumulation of both SAA1 , SAA2 and , while only SAA1 and SAA2 mRNA accumulation was seen after IL-6 stimulation . Positive_regulation TNF SAA4 14749357 1226344 [Tumor necrosis factor-alpha] *induces* in mouse granulosa cells . Positive_regulation TNF SAA4 16569709 1574727 We found that *stimulated* the production of [tumor necrosis factor (TNF)-alpha] and interleukin (IL)-10 , which are proinflammatory and anti-inflammatory cytokines , respectively , in human monocytes . Positive_regulation TNF SAA4 22076945 2574651 Acute-phase *regulates* [tumor necrosis factor] a and matrix turnover and predicts disease progression in patients with inflammatory arthritis before and after biologic therapy . Positive_regulation TNF SAG 18685727 1949265 peptides significantly *induced* a production of IFN-gamma and [tumor necrosis factor (TNF)-alpha] but not interleukin (IL)-2 , IL-4 , and IL-17 by peripheral blood mononuclear cells ( PBMCs ) in active BD patients with a response to S-Ag . Positive_regulation TNF SARS 24077366 2867244 Among the eight cytokine genes , IL-1ß , IL-6 and IL-8 induced by MERS-CoV were markedly higher than those induced by SARS-CoV at 30 h , whilst [TNF-a] , IFN-ß and IP-10 *induced* by were markedly higher than those induced by MERS-CoV at 24 and 30 h in infected Calu-3 cells . Positive_regulation TNF SBF1 15763366 1383377 We found that ( 0.05-0.25 mg/ml ) slightly *induced* [TNF-alpha] , IL-6 , NO ( nitric oxide ) and PGE2 ( prostaglandin E2 ) production in unstimualted murine macrophages , RAW264.7 cells . Positive_regulation TNF SBF2 15763366 1383378 We found that ( 0.05-0.25 mg/ml ) slightly *induced* [TNF-alpha] , IL-6 , NO ( nitric oxide ) and PGE2 ( prostaglandin E2 ) production in unstimualted murine macrophages , RAW264.7 cells . Positive_regulation TNF SCG2 15087472 1258124 [TNF-alpha] and IL-1 *induced* a time- and dose dependent increase in galanin , vasoactive intestinal polypeptide , and mRNA levels . Positive_regulation TNF SCG2 15320961 1286577 The addition of recombinant murine GM-CSF ( rMuGM-CSF ) to spleen cell cultures from various strains of mice synergistically enhanced IFN-gamma , [TNF-alpha] and IL-12p70 in the *presence* of . Positive_regulation TNF SCG2 16704300 1560646 We recently found that the splenocytes from naive DBA/1 and DBA/2 mice are potently *induced* by to produce interferon- gamma (IFN-gamma) , [tumor necrosis factor-alpha (TNF-alpha)] , granulocyte-macrophage colony stimulating factor ( GM-CSF ) , and interleukin-12p70 (IL-12p70) , and that GM-CSF plays a key biologic role among these cytokines . Positive_regulation TNF SCG2 16704300 1560661 directly *induced* adherent splenocytes to produce [TNF-alpha] and IL-12p70 . Positive_regulation TNF SCG2 16704300 1560673 GM-CSF was required for the *induction* of [TNF-alpha] by , and in turn , TNF-alpha enhanced the release of GM-CSF and thereby augmented the induction of IL-12p70 and IFN-gamma by SCG . Positive_regulation TNF SCG2 16985290 1617591 The levels of interferon-(IFN-)gamma , [tumor necrosis factor-(TNF-)alpha] , granulocyte-macrophage-colony stimulating factor ( GM-CSF ) , interleukin-(IL-) 6 and IL-12p70 were significantly *increased* by in CY-treated mice . Positive_regulation TNF SCG2 18729738 1956265 *induced* BMDCs to produce interleukin-12p70 (IL-12p70) , IL-6 , and [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF SCG3 15320961 1286579 The addition of recombinant murine GM-CSF ( rMuGM-CSF ) to spleen cell cultures from various strains of mice synergistically enhanced IFN-gamma , [TNF-alpha] and IL-12p70 in the *presence* of . Positive_regulation TNF SCG3 16704300 1560648 We recently found that the splenocytes from naive DBA/1 and DBA/2 mice are potently *induced* by to produce interferon- gamma (IFN-gamma) , [tumor necrosis factor-alpha (TNF-alpha)] , granulocyte-macrophage colony stimulating factor ( GM-CSF ) , and interleukin-12p70 (IL-12p70) , and that GM-CSF plays a key biologic role among these cytokines . Positive_regulation TNF SCG3 16704300 1560663 directly *induced* adherent splenocytes to produce [TNF-alpha] and IL-12p70 . Positive_regulation TNF SCG3 16704300 1560675 GM-CSF was required for the *induction* of [TNF-alpha] by , and in turn , TNF-alpha enhanced the release of GM-CSF and thereby augmented the induction of IL-12p70 and IFN-gamma by SCG . Positive_regulation TNF SCG3 16985290 1617593 The levels of interferon-(IFN-)gamma , [tumor necrosis factor-(TNF-)alpha] , granulocyte-macrophage-colony stimulating factor ( GM-CSF ) , interleukin-(IL-) 6 and IL-12p70 were significantly *increased* by in CY-treated mice . Positive_regulation TNF SCG3 18729738 1956267 *induced* BMDCs to produce interleukin-12p70 (IL-12p70) , IL-6 , and [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF SCG5 15320961 1286578 The addition of recombinant murine GM-CSF ( rMuGM-CSF ) to spleen cell cultures from various strains of mice synergistically enhanced IFN-gamma , [TNF-alpha] and IL-12p70 in the *presence* of . Positive_regulation TNF SCG5 16704300 1560647 We recently found that the splenocytes from naive DBA/1 and DBA/2 mice are potently *induced* by to produce interferon- gamma (IFN-gamma) , [tumor necrosis factor-alpha (TNF-alpha)] , granulocyte-macrophage colony stimulating factor ( GM-CSF ) , and interleukin-12p70 (IL-12p70) , and that GM-CSF plays a key biologic role among these cytokines . Positive_regulation TNF SCG5 16704300 1560662 directly *induced* adherent splenocytes to produce [TNF-alpha] and IL-12p70 . Positive_regulation TNF SCG5 16704300 1560674 GM-CSF was required for the *induction* of [TNF-alpha] by , and in turn , TNF-alpha enhanced the release of GM-CSF and thereby augmented the induction of IL-12p70 and IFN-gamma by SCG . Positive_regulation TNF SCG5 16985290 1617592 The levels of interferon-(IFN-)gamma , [tumor necrosis factor-(TNF-)alpha] , granulocyte-macrophage-colony stimulating factor ( GM-CSF ) , interleukin-(IL-) 6 and IL-12p70 were significantly *increased* by in CY-treated mice . Positive_regulation TNF SCG5 18729738 1956266 *induced* BMDCs to produce interleukin-12p70 (IL-12p70) , IL-6 , and [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF SDC2 16022734 1453199 *stimulated* up-regulation of [tumor necrosis factor-alpha (TNF-alpha)] , production of inducible nitric oxide synthase (iNOS) mRNA and accumulation of TNF-alpha protein and nitrite ( NO2- ) in a time- and concentration dependent manner . Positive_regulation TNF SDHC 1943475 170713 [Tumor necrosis factor] *induces* activation of mitochondrial . Positive_regulation TNF SDHD 11355520 815428 alone did not *induce* [TNF] secretion by PBMC , but when associated with a sub-optimal dose of armadillo derived M. leprae increased the release of this cytokine . Positive_regulation TNF SDHD 1943475 170714 [Tumor necrosis factor] *induces* activation of mitochondrial . Positive_regulation TNF SEA 11372026 817740 MAb5 blocked SEA binding to human monocytes , cross neutralized *induced* T cell mitogenesis and [TNF-alpha] secretion in human peripheral blood mononuclear cells , and prevented lethality in mice . Positive_regulation TNF SEA 1371491 179677 FK506 or CsA inhibited *induced* [tumour necrosis factor-alpha (TNF-alpha)] production both in monocytes ( P less than 0.01 ) and in lymphocytes ( P less than 0.001 ) , at a drug concentration of 1-25 ng/ml for FK506 and 100-500 ng/ml for CsA . Positive_regulation TNF SEA 18285496 1896487 [Tumor necrosis factor] alpha levels in *response* to stimulation with were high , and a negative association between presentation with hepatomegaly and the levels of the regulatory cytokines interleukin-6 and transforming growth factor beta(1) suggests that a possible mechanism for childhood hepatomegaly in areas where both malaria and schistosomiasis are endemic is poor regulation of an inflammatory response to schistosome eggs . Positive_regulation TNF SEA 19375418 2081811 Increased production of [TNF-alpha] and IL-1 in alveolar macrophages was observed in *response* to and SEB . Positive_regulation TNF SEA 22510830 2584221 We demonstrate that stimulation with *induced* prominent lymphocyte proliferation and high levels of [tumour necrosis factor (TNF)-a] , interleukin (IL)-4 and IL-10 secretion in both OST and non infected individuals ( NI ) . Positive_regulation TNF SEA 7608567 311956 We have studied the transcriptional *activation* of the human [TNF-alpha] gene by the superantigen in the human premonocytic cell line THP-1 . Positive_regulation TNF SEA 7691731 230948 Reverse transcriptase-polymerase chain reaction ( RT-PCR ) analysis demonstrated that *induced* [TNF-alpha] and IFN-gamma mRNA reached maximal levels 1 hr after SEA administration in TGV beta 3 mice , whereas peak serum levels of TNF-alpha and IFN-gamma proteins were recorded after 2 hr. Comparison of the mRNA levels of a panel of cytokines in the TGV beta 3 and non-TG mice revealed that almost similar amounts of interleukin-1 (IL-1) were induced in both strains , whereas IL-4 was only detected at significant levels in the TGV beta 3 mouse . Positive_regulation TNF SEA 8145023 252594 However , only *induced* increased [TNF] mRNA levels . Positive_regulation TNF SEA 8687436 370457 A synthetic peptide of this region , SEA ( 121-149 ) , blocks binding to class II MHC molecules and *induces* interleukin-1 and [tumor necrosis factor] production in monocytes . Positive_regulation TNF SEA 8806793 382666 The results of this study indicate that *induces* the secretion of IL-1 alpha and [TNF alpha] by epidermal cells , that these cytokines induce LC depletion from epidermis , and that antibodies specific for these agents inhibit the depletion of LC by SEA . Positive_regulation TNF SEA 9009284 410970 Pretreatment of SEA with 0.1 mg of IVIG per ml resulted in a slight decrease of *induced* [TNF-alpha] secretion by MO . Positive_regulation TNF SELE 10657661 664146 These results indicate that the PKR is required for full *activation* of expression by pIC and [TNF-alpha] in primary mouse aortic endothelial cells identifying activating transcription factor 2 as a new target for PKR dependent regulation and suggest a role for PKR in leukocyte adhesion . Positive_regulation TNF SELE 10807781 692328 [Tumor necrosis factor-alpha] *induced* the expression of VCAM-1 , , and ICAM-1 but had no effect on P-selectin expression . Positive_regulation TNF SELE 11355655 815436 Control skin displayed no expression of E- and P-selectin , whereas [TNF-alpha] *induced* the expression of P-selectin and on dermal vessels that was highest at 12 hours and 3 hours , respectively ( P < 0.05 ) . Positive_regulation TNF SELE 11355655 815439 These results demonstrate that [TNF-alpha] can *induce* the expression of P- and in vivo in dog skin and suggest that these selectins are involved in leukocyte recruitment in canine dermatitis . Positive_regulation TNF SELE 11678640 873685 [TNF-alpha] *induced* the expression of on all three kinds of endothelial cells , but IFN-gamma had no effect on E-selectin expression . Positive_regulation TNF SELE 12420742 1013419 Without NH2Cl , [TNF-alpha] *induced* marked expression of and ICAM-1 . Positive_regulation TNF SELE 14630701 1188069 Lovastatin mediated block of [TNF-alpha] *induced* expression is due to inhibition of protein geranylgeranylation rather than farnesylation . Positive_regulation TNF SELE 14682399 1179327 Using semi-quantitative RT-PCR and cell based ELISA , we demonstrated that [tumor necrosis factor-a] *induced* the expression of intercellular adhesion molecules-1 and , as well as monocyte chemoattractant protein-1 , in a time- and dose dependent manner in primary human coronary artery endothelial cell cultures . Positive_regulation TNF SELE 15113938 1241386 [TNF-alpha] significantly *induced* HUVEC protein expression of VCAM-1 , ICAM-1 , and with increasing mRNA levels . Positive_regulation TNF SELE 15265939 1275743 We found that compound 10 1 ) dramatically inhibits TNF-alpha induced VCAM-1 mRNA and protein expression in human aortic endothelial cells ( HAEC ) , has a relatively modest inhibitory effect on [TNF-alpha] *induced* expression and has no effect on ICAM-1 expression ; Positive_regulation TNF SELE 15625106 1362071 As in skin , [TNF] *induces* and vascular cell adhesion molecule 1 only on venular ECs , whereas intercellular adhesion molecule-1 is up-regulated on all human ECs . Positive_regulation TNF SELE 15694007 1376334 Trogliazone ( 20 microM ) reduced [TNF-alpha] *induced* VCAM-1 , ICAM-1 and expression . Positive_regulation TNF SELE 15880045 1406193 [Tumor-necrosis factor-alpha] stimulation of PAEC-Gal-/- and PAEC-Gal+/+ *induced* an increase of and CD106 expression and increased cellular adhesion , in particular , of PMN . Positive_regulation TNF SELE 16353157 1526370 We show that phenoxodiol inhibits hallmarks of endothelial cell activation , namely [TNF] or IL-1 *induced* and VCAM-1 expression and IL-8 secretion . Positive_regulation TNF SELE 1697876 139667 is normally not expressed by HUVE cells , but its expression can rapidly be *induced* by [TNF] , IL-1 , or LPS . Positive_regulation TNF SELE 18212564 1857922 None of the four agents had an effect on [TNF-alpha] *induced* expression . Positive_regulation TNF SELE 18292233 1885516 In organ culture , [TNF] *induced* expression of , VCAM-1 , and ICAM-1 on HUVECs but only ICAM-1 on HUAECs . Positive_regulation TNF SELE 20465310 2268800 [TNF-alpha] markedly *induced* protein expression of cell adhesion molecule and with increasing mRNA levels in HUVEC . Positive_regulation TNF SELE 20954188 2369334 , a leukocyte adhesion molecule expressed on endothelium , is *induced* by [tumor necrosis factor a (TNFa)] and other cytokines involved in the pathogenesis of rheumatoid arthritis ( RA ) . Positive_regulation TNF SELE 23235150 2731727 Increased expression of adipose tissue cytokines IL-1ß , CCL2 , and [TNF-a] in response to CL 316,243 administration is also *dependent* upon but not P-selectin . Positive_regulation TNF SELE 7504714 244324 ICAM-1 , VCAM-1 , and were all *induced* by dsRNA ( poly ( I:C ) ) , IL-1 beta , [TNF-alpha] , and LPS in KS cells . Positive_regulation TNF SELE 7526034 277078 C11STH cells do not express CD34 or show transforming growth factor-beta inhibition of [TNF-alpha] *induced* expression , functions indicative of primary , or early passage HUVECs . Positive_regulation TNF SELE 7536438 297252 [TNF-alpha] *induced* endothelial , intercellular adhesion molecule-1 ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) in all groups , and adhesion molecule expression by interstitial dermal dendritic cells ( ICAM-1 and VCAM-1 ) and keratinocytes ( ICAM-1 ) was observed . Positive_regulation TNF SELE 7537468 300907 [Tumor necrosis factor] *induces* production in splanchnic artery occlusion shock . Positive_regulation TNF SELE 7538441 301308 Here , we show that peptide aldehyde inhibitors of the proteasome , a multicatalytic protease recently shown to be required for the activation of NF-kappa B , block [TNF alpha] *induction* of the leukocyte adhesion molecules , VCAM-1 , and ICAM-1 . Positive_regulation TNF SELE 7693806 234202 [TNF-alpha] increases the expression of ICAM-1 , but not ICAM-2 , and *induces* the expression of on both EC types . Positive_regulation TNF SELE 7962270 279360 Expression of on endothelial cells was *induced* only by IL-1 alpha , not by IFN gamma or [TNF alpha] . Positive_regulation TNF SELE 8194873 259002 [TNF alpha] *induced* increased expression of and VCAM-I adhesion molecules on intratumoral endothelial cells . Positive_regulation TNF SELE 8356403 227513 [TNF-stimulation] also *induced* expression on EA-hy-926 and HUVEC and an accompanying increase in neutrophil ( PMN ) binding . Positive_regulation TNF SELE 8568264 350972 In the lungs , but not in other organs , transient expression was *induced* by [TNF] within 0.5 h and peaked at 4 h . Positive_regulation TNF SELE 8579110 350481 Locally produced interleukin-1 and [tumor necrosis factor-alpha (TNF-alpha)] *induced* vascular cellular adhesion molecule-1 ( VCAM-1 ) and on tumor vessels . Positive_regulation TNF SELE 8666424 369081 [TNF-alpha] but not the other human cytokines unregulated swine leucocyte antigens (SLA) class I , class II and B7 receptor expression and *induced* vascular cell adhesion molecule ( VCAM ) and expression . Positive_regulation TNF SELE 8751905 377222 With Escherichia coli LPS , [tumor necrosis factor] alpha activation requires membrane bound CD14 and expression *requires* soluble CD14 ( sCD14 ) . Positive_regulation TNF SELE 9164965 432158 Although IL-1 and [TNF-alpha] also *induce* IL-8 and , the thrombin effects in these experiments were not mediated by those cytokines , since neither IL-1 receptor antagonist nor anti-TNF-alpha Ab inhibited the effects of thrombin . Positive_regulation TNF SELE 9728048 530024 These findings indicate that [TNF-alpha] *induces* NF-kappaB activation and the resultant gene expression by a pathway that involves formation of ROS and that E-selectin expression can be inhibited by the antioxidant action of NAC or PDTC . Positive_regulation TNF SELL 16461740 1540828 Following Con A treatment , deficiency *reduced* liver mRNA expression of [tumor necrosis factor-alpha] , and ICAM-1 deficiency reduced expression of interleukin-4 . Positive_regulation TNF SELP 10899315 712371 Density dependent *induction* of [TNF-alpha] release from human monocytes by immobilized . Positive_regulation TNF SELP 10899315 712372 purified from human platelets , when immobilized on a solid surface , *induced* monocytes to release [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF SELP 11355655 815437 Control skin displayed no expression of E- and P-selectin , whereas [TNF-alpha] *induced* the expression of and E-selectin on dermal vessels that was highest at 12 hours and 3 hours , respectively ( P < 0.05 ) . Positive_regulation TNF SELP 14628445 1170344 [TNF-alpha] *induced* HUVEC expression ICAM-1 and thrombin induced platelets expression of were measured by flow cytometry . Positive_regulation TNF SELP 14680834 1179181 ( 4 ) NMSO3 inhibited *induced* [tumor necrosis factor-alpha] production in monocytes and activated platelet induced generation of reactive oxygen species in neutrophils . Positive_regulation TNF SELP 23018521 2726845 The secretion of [tumor necrosis factor (TNF)-a] , interleukin (IL)-1ß , IL-6 , IL-8 , IL-12 and macrophage inflammatory protein-1ß increased 3- to 10-fold in *response* to compared with unstimulated monocytes . Positive_regulation TNF SELP 23235150 2731728 Increased expression of adipose tissue cytokines IL-1ß , CCL2 , and [TNF-a] in response to CL 316,243 administration is also *dependent* upon E-selectin but not . Positive_regulation TNF SENP1 18219322 1876735 [TNF] *induces* the release of from thioredoxin as well as nuclear translocation of SENP1 . Positive_regulation TNF SERINC3 16715133 1638308 We further show that whereas is not *required* for [TNFalpha] or TRAIL induced activation of NF-kappaB or caspase-8 , it can promote caspase-8 activation independently of death receptor-ligand interactions . Positive_regulation TNF SERPINA1 21723846 2466027 production by SCC cells was dependent on p38 mitogen activated protein kinase activity and was *up-regulated* by epidermal growth factor , [tumor necrosis factor-a] , interferon-? , and IL-1ß . Positive_regulation TNF SERPINA1 9445306 483336 and protease complexation is *induced* by lipopolysaccharide , interleukin-1beta , and [tumor necrosis factor-alpha] in monocytes . Positive_regulation TNF SERPINA3 19800391 2159491 *induces* [TNF-alpha] production and NF-kappaB activation in the murine N9 microglial cell line . Positive_regulation TNF SERPINA3 8747137 343520 IL-1 beta and [TNF alpha] , but not IL-6 , *induce* expression in the human astrocytoma cell line U373 MG . Positive_regulation TNF SERPINA3 8863511 388840 Interleukin-1 beta and [tumor necrosis factor-alpha] *induce* expression of in human astrocytoma cells by activation of nuclear factor-kappa B . Positive_regulation TNF SERPINB2 1389210 198713 release is *induced* by [TNF-alpha] and TGF-beta . Positive_regulation TNF SERPINB2 2555368 122018 By 3-5 h , PMA or [TNF] *induced* both tissue factor and to approximately 150-420 mRNA molecules/cell and both mRNAs declined to basal levels within several hours ; Positive_regulation TNF SERPINC1 10531211 562066 h , MCP-1 , gamma interferon , and [TNF] were *detected* in extracts of pulmonary tissue or in bronchoalveolar lavage (BAL) fluid . Positive_regulation TNF SERPINE1 10362602 620065 [TNF-alpha] and insulin , alone and synergistically , *induce* expression in adipocytes . Positive_regulation TNF SERPINE1 12511973 1027603 Because TNFalpha induces PAI-1 production in endothelial cells , and NAC attenuated this response , we attempted to investigate the possible involvement of ROS in the *activation* of by [TNFalpha] . Positive_regulation TNF SERPINE1 12905793 1030914 ( 1 ) [TNF-alpha] or mmLDL could *induce* activity and mRNA expression in HUVECs . Positive_regulation TNF SERPINE1 1415727 201572 In dose and time-course studies , HLF plasminogen activator inhibitor-1 ( PAI-1 ) was increased by TGF-beta , whereas [TNF-alpha] *induced* release of into the media . Positive_regulation TNF SERPINE1 1436316 204841 their numbers increased gradually over 24 h . [Tumor necrosis factor (TNF)] also *induced* a progressive increase in activity in normal rats . Positive_regulation TNF SERPINE1 14534369 1165049 [TNF-alpha] *induced* mRNA expression and protein production in human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation TNF SERPINE1 16052513 1447818 Treatment with SalB ( 0.05 and 0.15 microM ) notably attenuated [TNF-alpha] *induced* expression of to 90.5 % and 74.6 % , respectively , after 12 h , and to 75.1 % and 64.2 % , respectively , after 18 h . Positive_regulation TNF SERPINE1 16190362 1462606 Hypoxia , [TNF-alpha] and their combination *induced* a 2.8-fold , a 1.8-fold , and a 4.6-fold increase in protein secretion , and produced a 3.6-fold , a 3.3-fold , and a 12.1-fold increase at the PAI-1 mRNA level , respectively . Positive_regulation TNF SERPINE1 19450557 2090764 Shear stress and [TNF-alpha] additively *induced* , whereas shear stress blocked the cytokine effect on t-PA and u-PA . Positive_regulation TNF SERPINE1 8547638 346401 [TNF] alone *induced* a more marked accumulation of than of uPA . Positive_regulation TNF SERPINE1 8547638 346403 Association of [TNF] with the agents *induced* a response that was more than additive of the two , whereas the secretion of uPA was not enhanced . Positive_regulation TNF SERPINE1 9580327 499264 The elevated [TNFalpha] in the placenta may *induce* and TF , and thus promote the thrombotic alterations associated with preeclampsia . Positive_regulation TNF SERPINF1 22714715 2700992 Selective inhibition of ATGL on macrophages attenuates *induced* [TNF] production , and PEDF enhances the phosphorylation of p38 and extracellular signal regulated kinase 1/2 mitogen activated protein kinases . Positive_regulation TNF SERPINF1 24367624 2881811 In adipocytes , was *induced* by [TNF-a] through activation of NF-?B . Positive_regulation TNF SERPING1 9777421 540261 Interferon-gamma and alpha (IFN) , colony stimulating factor-1 , interleukin-6 (IL-6) and [tumor necrosis factor-alpha (TNF-alpha)] all *induce* synthesis in a variety of cell types . Positive_regulation TNF SETBP1 10569782 568064 In this study , we have used mixed cultures of human peripheral blood monocytes and lymphocytes to investigate biochemical events controlling *induction* of [TNF-alpha] . Positive_regulation TNF SETBP1 10569782 568065 [TNF-alpha] production *induced* by in mixed cultures is more closely associated with T cells than with monocytes : ( i ) a TCR-binding-site mutant of SEB ( N23F ) is less active in TNF-alpha induction than an MHC class II receptor-binding-site mutant ( F44R ) , and ( ii ) flow cytometric analysis indicated that SEB induced TNF-alpha production in T cells but not in monocytes . Positive_regulation TNF SETBP1 10569782 568067 Pretreatment of cells with inhibitors of signal transduction pathways was employed to further define events in *induced* [TNF-alpha] production . Positive_regulation TNF SETBP1 10569782 568068 Neither protein kinase A inhibitors nor two protein tyrosine kinase inhibitors altered *induced* [TNF-alpha] production . Positive_regulation TNF SETBP1 10569782 568070 Alteration of levels of diacylglycerol ( DAG ) , an activator of PKC , by treatment with inhibitors of phospholipase C or DAG kinase also altered *induced* [TNF-alpha] production . Positive_regulation TNF SETBP1 10569782 568071 These data suggest that PKC activation plays a critical role in *induced* [TNF-alpha] production in human T cells . Positive_regulation TNF SETBP1 10816471 693686 MAb5 was found to partially inhibit *induced* T-cell mitogenesis ( 63 % ) and [tumor necrosis factor alpha (TNF-alpha)] secretion ( 70 % ) in human peripheral blood mononuclear cells ( PBMC ) in a dose dependent manner , while an isotypic anti-TSST-1 monoclonal antibody showed no effect . Positive_regulation TNF SETBP1 10816471 693687 SEB peptide ( 83 ) DVFGANYYYQ ( 92 ) was synthesized and found to also inhibit *induced* mitogenesis and [TNF-alpha] secretion in human PBMC . Positive_regulation TNF SETBP1 11141330 770183 The *induced* [TNF] response in vitro and in vivo was stronger in resistant B10 .BR mice than in susceptible C3H/HeJ mice . Positive_regulation TNF SETBP1 11442023 833491 All monkeys made IL-2 , [TNF] , and IFN-gamma in *response* to . Positive_regulation TNF SETBP1 11546726 856638 To investigate the efficacy of S ( + ) -ketamine and R ( - ) -ketamine on *induced* [tumour necrosis factor (TNF)-] , interleukin (IL)-6 , and IL-8 production in human whole blood in vitro . Positive_regulation TNF SETBP1 11546726 856639 Ketamine isomers significantly suppressed *induced* [TNF-] production at concentrations exceeding 50 microM . Positive_regulation TNF SETBP1 11546726 856642 This study demonstrated that ketamine isomers suppressed *induced* [TNF-] , IL-6 , and IL-8 production in human whole blood . Positive_regulation TNF SETBP1 12230915 988348 Peritoneal macrophages from C3H/HeJ mice did not produce [TNF-alpha] in vitro in *response* to or LPS . Positive_regulation TNF SETBP1 12883826 1142767 Furthermore , EGCg inhibited *induced* [TNF-alpha] and IFN- gamma production and IL-2 , IFN-gamma , IL-10 and IL-12 p40 mRNA expression in human PBMCs from normal donors in a dose dependent manner . Positive_regulation TNF SETBP1 1402393 199584 We investigated the influence of CKS-17 , a synthetic heptadecapeptide that corresponds to a highly conserved domain of the immunosuppressive retroviral envelope protein p15E , on *induced* [TNF-alpha] gene expression in human peripheral blood mononuclear cells and highly purified human monocyte preparations , as well as the production of TNF-alpha protein , using human peripheral blood mononuclear cells . Positive_regulation TNF SETBP1 1402393 199585 RNA hybridization studies show that CKS-17 inhibits *induced* [TNF-alpha] mRNA accumulation in human peripheral blood mononuclear cells and human monocytes . Positive_regulation TNF SETBP1 1402393 199586 CKS-17 is also shown to be highly suppressive for *induced* production of [TNF-alpha] proteins . Positive_regulation TNF SETBP1 14560009 1154036 We demonstrate here that superantigen *induced* a dramatic upregulation of FasL , TRAIL , and [TNF] mRNA expression and function in IEC from BALB/c and C57BL/6 mice . Positive_regulation TNF SETBP1 15041592 1224507 We designed this study to investigate the effects of local anesthetics on monocyte mCD14 and human leukocyte antigen ( HLA ) -DR expression and lipopolysaccharide (LPS) induced or *induced* [tumor necrosis factor (TNF)-alpha] production . Positive_regulation TNF SETBP1 15041592 1224508 The effects of local anesthetics on LPS- or *induced* [TNF-alpha] production were determined by using an enzyme linked immunosorbent assay . Positive_regulation TNF SETBP1 15041592 1224509 Local anesthetics showed no effect on LPS- or *induced* [TNF-alpha] production in human whole blood . Positive_regulation TNF SETBP1 15155343 1250407 TCV-309 significantly inhibited the production of [TNF] , IL-6 , and IL-8 *induced* by LPS , , and bacteria . Positive_regulation TNF SETBP1 15253857 1271697 In human PBMCs , YZH inhibited *stimulated* cytokine ( interleukin [ IL]-1 , IL-2 , IL-6 , tumor necrosis factor [ [TNF]-alpha] , interferon [ IFN]-gamma ) and chemokine ( IP-10 , MCP-1 , MIP-1alpha and MIP-1beta ) production in a dose dependent manner . Positive_regulation TNF SETBP1 15265541 1275317 Naltrexone significantly inhibited the production of [TNF-alpha] *induced* by LPS , but not in vivo . Positive_regulation TNF SETBP1 16213476 1489130 Pretreatment or co-treatment of human PBMC or murine lymphnode cells with EGCG significantly reduced *induced* proliferation and IL-2 , IFNgamma , and [TNFalpha] production . Positive_regulation TNF SETBP1 18364436 1912759 induced signaling in macrophages *leads* to biphasic [TNF-alpha] . Positive_regulation TNF SETBP1 20041187 2177291 The binding of to Vbeta chain *results* in rapid activation of T cells and production of inflammatory cytokines , such as Interleukin-2 (IL-2) , Interferon-gamma and [Tumor Necrosis Factor-alpha] which mediate TSS . Positive_regulation TNF SETBP1 20634937 2292163 *induced* low levels of [TNFalpha] , IL-1 , IFNgamma , MIP-2 , and LPS synergized with SEB in the expression of these cytokines and that of IL-6 and MCP-1 . Positive_regulation TNF SETBP1 22639228 2744840 However , only treatment with LPS , but not , *enhanced* amygdaloid IL-1ß and [TNF-a] mRNA expression . Positive_regulation TNF SETBP1 24423010 2901223 Despite significantly decreasing serum levels of IL-2 , IL-6 and [TNF] *induced* by in wild-type mice , human MSCs failed to improve survival in experimental TSS in HLA-DR4 transgenic mice . Positive_regulation TNF SETBP1 7520469 266310 In vitro experiments indicated that NO synthase (NOS) inhibition by N-nitro-L-arginine methyl ester ( L-NAME ) enhanced IFN-gamma and [TNF] production by splenocytes in *response* to . Positive_regulation TNF SETBP1 7665990 322105 Furthermore , ethanol treatment ( 25-100 mM ) significantly inhibited SEA- or *induced* production of [tumor necrosis factor-alpha (TNF-alpha)] , interleukin-1 beta (IL-1 beta) , and IL-6 in monocytes . Positive_regulation TNF SETBP1 8258334 238641 Monoclonal antibodies directed against HLA-DR and -DQ abolished the *induced* expression of both the IL-1 beta and [TNF-alpha] genes , suggesting that the HLA class II molecules mediated the gene expression . Positive_regulation TNF SETBP1 8299910 248595 *induced* the production of [TNF-alpha] and IFN-gamma in a dose dependent manner from splenic mononuclear cells in vitro . Positive_regulation TNF SETBP1 8299910 248599 The results show that SEB contributes to lethal shock associated with severe hepatic injury in GalN sensitized mice and suggest that [TNF-alpha] and IFN-gamma produced in *response* to may be mediators of the lethal toxicity and hepatotoxicity of SEB . Positive_regulation TNF SETBP1 8960643 402279 In *response* to , patients with sepsis and patient with septic shock demonstrated significantly decreased release of [TNF-alpha] and IL-1beta . Positive_regulation TNF SETBP1 9009284 410971 In contrast , pretreatment of SEB with 0.1 mg of IVIG per ml resulted in significant ( greater than 50 % ) inhibition of SEB induced TNF-alpha secretion at 24 , 48 , 72 , and 96 h ( P < 0.05 for [TNF-alpha] levels *induced* by alone versus SEB pretreated with IVIG at all time points ) . Positive_regulation TNF SETBP1 9260332 448722 Anti-CD3 mAb as well as or Con A *induced* the release of systemic [tumor necrosis factor (TNF)] , interferon gamma (IFN gamma) , and various other cytokines . Positive_regulation TNF SETBP1 9864222 582823 In vitro stimulation of monocytes isolated from soluble beta-glucan treated mice with LPS also resulted in suppressed TNF-alpha production , while stimulation of these cells with or TSST-1 *resulted* in suppressed IL-6 and [TNF-alpha] production compared to that in cells isolated from untreated mice . Positive_regulation TNF SETBP1 9916683 587473 [TNF-alpha] production by peripheral T cells in *response* to and anti-CD28 mAb correlated more closely with ERK activity than with p38 activity . Positive_regulation TNF SETD2 20689059 2322875 Lastly , partial deficiency *reduced* [TNF-a] , IL-1ß , cyclooxygenase-2 , and inducible nitric oxide synthase levels in the ileal mucosa after T/HS whereas IL-1ß mRNA levels were reduced in the lung after T/HS . Positive_regulation TNF SETD2 23085511 2698946 In this study , we investigated direct effects of hypoxia on TNF-a expression of cardiomyocytes , the *role* of in [TNF-a] regulation and potential secretory pathway of TNF-a . Positive_regulation TNF SETD2 23085511 2698948 Results of this study indicate that under hypoxia , *initiates* expression of [TNF-a] , mediated by exosomes in cardiomyocytes . Positive_regulation TNF SETD2 24081113 2863374 overexpression also *enhanced* IL-1ß , IL-6 and [TNF-a] mRNA expression . Positive_regulation TNF SF1 22358893 479183 However , *stimulated* the production of IL-1 , IL-6 , and [TNF] as much as LPS , while SF2 induced them only weakly or not at all . Positive_regulation TNF SFTPA2 16709567 1584554 is also a potent *activator* of [tumor necrosis factor alpha (TNF-alpha)] receptor 1 ( TNFR1 ) signaling , inducing both chemokine expression and TNF converting enzyme dependent soluble TNFR1 ( sTNFR1 ) shedding , which has anti-inflammatory consequences , particularly in the lung . Positive_regulation TNF SFTPA2 8698480 372895 On the other hand , *induced* the release of IL-1 , IL-6 , and [tumor necrosis factor (TNF)] and enhanced the expression of IL-1alpha , IL-1beta , IL-6 , and TNF alpha (TNF-alpha) mRNAs . Positive_regulation TNF SGCG 7927746 273963 Both agents contributed to the downregulation of *induced* IL-1 beta and [TNF-alpha] gene expression . Positive_regulation TNF SGCG 8188366 256766 Finally , our results , obtained with protein tyrosine kinase inhibitors and antiphosphotyrosine Western blotting ( immunoblotting ) , indicate that protein tyrosine kinase is involved in *induced* IL-1 beta and [TNF-alpha] gene expression in the THP-1 monocytic cell line . Positive_regulation TNF SHBG 7587894 329800 50 and 100 % mg/kg ip could potentiate LAK cell activity and *increase* the Con A ( 5 micrograms/ml ) -induced production of [tumor necrosis factor] ( TNF-beta ) from murine splenocytes . Positive_regulation TNF SIGLEC1 18414664 1894285 In cultured CD14 ( + ) monocytes isolated from healthy individuals , expression was *induced* by interferon-alpha and interferon-gamma but not [tumor necrosis factor-alpha] . Positive_regulation TNF SIGLEC14 19369701 2100640 The forced expression of in a monocytic cell line *enhanced* [TNF-alpha] secretion elicited by lipopolysaccharide . Positive_regulation TNF SIGLEC7 23029261 2680822 Here , we demonstrate that cross linking of by a specific monoclonal antibody ( mAb ) *induces* a remarkably high production of IL-6 , IL-1a , CCL4/MIP-1ß , IL-8 and [TNF-a] . Positive_regulation TNF SIL1 21745554 2471884 Importantly , and TNF-a acted synergistically to upregulate key inflammatory regulators in AEII cells , including the expression of inducible NO synthase and cyclooxygenase-2 (COX-2) , and *enhanced* prostaglandin E2 production and expression of proinflammatory cytokines , such as [TNF-a] , interleukin-1ß and interleukin-6 . Positive_regulation TNF SIL1 23446805 2749247 In addition , *induced* the release of interleukin (IL)-1ß and [tumor necrosis factor-a] from these cells . Positive_regulation TNF SIRPB1 14635062 1171049 By contrast , in the absence of KARAP/DAP12 , engagement of : DAP10 complexes does not *lead* to detectable serotonin release or [TNF] secretion by RBL-2H3 transfectants . Positive_regulation TNF SIRT1 19299582 2064129 In the present study , we examined the *role* of signaling in [TNF-alpha] generation stimulated by either lipopolysaccharide (LPS) , acetaldehyde (AcH) , or acetate ( two major metabolites of ethanol ) in two cultured macrophage cell lines . Positive_regulation TNF SIRT1 22069489 2504290 *Activation* of by resveratrol inhibits [TNF-a] induced inflammation in fibroblasts . Positive_regulation TNF SIRT1 23778143 2815369 was upregulated through c-MYC in embryonic and postnatal Pkd1-mutant mouse renal epithelial cells and tissues and could be *induced* by [TNF-a] , which is present in cyst fluid during cyst development . Positive_regulation TNF SIRT6 23086953 2703570 In turn , TRPM2 and Ca ( 2+ ) are shown to be involved in *induced* [TNF] and IL8 expression . Positive_regulation TNF SIRT6 23552949 2767252 *regulates* [TNF-a] secretion through hydrolysis of long-chain fatty acyl lysine . Positive_regulation TNF SKP1 10889302 710424 However , we observed that used as a co-stimulus significantly *potentiated* histamine and [TNF-alpha] release in canine MC activated through Fc epsilon RI regardless of whether or not SCF was added to the medium during culturing . Positive_regulation TNF SKP1 11763385 887881 Moreover , [TNF-alpha] *induced* expression of CD54 by cells in the medium , but not by those retained in the sheets , whereas human induced , dose dependently , expression of CD54 by cells in the sheets , but not from those in the medium . Positive_regulation TNF SKP1 16436136 1516382 Either SCF or [TNF-alpha] could *induce* release from HMC-1 cells of interleukin (IL)-8 , monocyte chemoattractant protein (MCP)-1 , regulated upon activation normal T-cell expressed and secreted ( RANTES ) , and I-309 , while and TNF-alpha induced release of macrophage inflammatory protein (MIP)-1beta and interferon-gamma-inducible protein-10 (IP-10) , respectively . Positive_regulation TNF SKP1 17320132 1719744 In addition , production of [tumor necrosis factor (TNF)-alpha] , interleukin (IL)-1beta , and vascular endothelial growth factor ( VEGF ) production *induced* by was significantly inhibited by treatment with SC-236 . Positive_regulation TNF SKP1 18549896 1923754 In vitro studies using primary mouse hepatocytes show that is *induced* by [TNF-alpha] ; Positive_regulation TNF SKP1 8809429 383141 Changes in the level of mastocytoma mRNA for [TNF alpha] in *response* to stimulation with or fibroblast conditioned media for up to 12 weeks were studied using Northern analysis and changes in the level of TNF alpha protein expression on immunoblot and immunocytochemistry . Positive_regulation TNF SKP1 9637535 513872 was constitutively produced from fibroblasts in its transmembrane form and could be *induced* by [TNF] . Positive_regulation TNF SKP1 9759885 536633 Coligation of SCFR augmented Fc epsilonRI mediated activation of MAP kinases , especially JNK activation , and *augmented* Fc epsilonRI mediated [TNF-alpha] production in MC/9 cells , although SCF alone did not induce TNF-alpha production . Positive_regulation TNF SLAMF6 15162436 1253005 Functionally , in NK cells , *promoted* a strong production of IFN-gamma and [TNF-alpha] . Positive_regulation TNF SLC12A9 7629160 316647 Taken together these results suggest that Rb , p53 , and ( p21 ) proteins mediate TNF-alpha antimitogenic activity , and [TNF-alpha] *induces* growth arrest in the G1 phase in MCF-7 cells . Positive_regulation TNF SLC18A2 20498218 2319896 In addition , blockade *increased* cyclic AMP ( cAMP ) and cAMP responsive element binding protein , responsible for [TNF] inhibition . Positive_regulation TNF SLC1A2 18381653 1913012 Regulation of both EAAT-1 and is mediated by NF-kappaB , and this transcriptional regulator is also *required* for increased production of [TNFalpha] . Positive_regulation TNF SLC1A3 18381653 1913013 Regulation of both and EAAT-2 is mediated by NF-kappaB , and this transcriptional regulator is also *required* for increased production of [TNFalpha] . Positive_regulation TNF SLC22A3 18294286 1891604 Moreover , [TNF-alpha] *induced* the of 786-O cells by repressing E-cadherin , promoting vimentin expression , and activating MMP9 activity . Positive_regulation TNF SLC22A3 21196756 2425341 We investigated whether TGF-ß1 and/or [TNF-a] *induce* in bronchial epithelial cells . Positive_regulation TNF SLC22A3 21856755 2473273 In the present study , [TNF-a] *induced* of RCC cells by repressing E-cadherin , promoting invasiveness and activating matrix metalloproteinase (MMP) 9 activity . Positive_regulation TNF SLC22A3 22565852 2763351 This study aimed to determine the *inducing* activity of proinflammatory cytokine [TNF-a] and the role for complement 3 ( C3 ) in this activity in an in vitro model of human RTECs ( HK-2 cells ) . Positive_regulation TNF SLC22A3 22565852 2763353 Our preliminary observations suggest that [TNF-a] may *induce* in RTECs through inducing C3 expression . Positive_regulation TNF SLC25A3 18601946 1953906 The results indicate that can increase the activity of LDH and ACP in AMphi and PMphi of rats and human mononuclear cells , and *enhance* the pinocytic activity of macrophages and [TNF-alpha] production by human peripheral blood mononuclear cells ( PBMC ) , suggesting that PtP had potent immunomodulatory properties and could be explored as a novel potential immunostimulants for the food and pharmaceutical purpose . Positive_regulation TNF SLC28A1 15464233 1305048 [TNF-alpha] and IL-6 independently *induced* protein expression in cultured liver parenchymal and FAO hepatoma cells by PI-3 kinase- and ERK dependent mechanisms , respectively . Positive_regulation TNF SLC2A4 15298339 1283463 In contrast , exercise training did not significantly change [TNF-alpha] protein expression , but protein expression *increased* by 105 +/- 37 % ( p < 0.05 ) . Positive_regulation TNF SLC33A1 12746279 1088668 receptor blockade with valsartan *prevented* the increase in [TNF-alpha] in the diabetic group . Positive_regulation TNF SLC33A1 19540938 2121312 Moreover , the production of IFN-gamma and [TNF-alpha] through CTL stimulation can be *inhibited* by the selective inhibitor , Losartan . Positive_regulation TNF SLC33A1 20065159 2201272 Our findings demonstrate that *mediated* [tumor necrosis factor-alpha] induction , by overcoming its negative regulator , heme oxygenase-1 , is a key underlying mechanism responsible for impaired placental angiogenesis by inducing both sEng and soluble fms-like tyrosine kinase-1 secretion from human villous explants . Positive_regulation TNF SLC33A1 23089979 2698987 *increased* [TNF] secretion and caspase-3 activities . Positive_regulation TNF SLC33A1 23089979 2698989 AT1 receptor blockade completely abrogated *induced* [TNF-a] secretion , caspase-3 activation , and cardiomyocyte apoptosis . Positive_regulation TNF SLC5A2 22351116 2636707 In conclusion , this study showed that *increased* in the presence of IL-6 and [TNF-a] , indicating an autocrine modulation of the expression of this transporter by cytokines . Positive_regulation TNF SLC7A1 9473147 476321 [TNF-alpha] ( 10 ng/ml for 1-24 h ) *induced* a time dependent increase in CAT-2 but not expression . Positive_regulation TNF SLC7A2 9473147 476322 [TNF-alpha] ( 10 ng/ml for 1-24 h ) *induced* a time dependent increase in but not CAT-1 expression . Positive_regulation TNF SLC8A1 23224891 2718511 Our results demonstrate that human macrophages and monocytes express and NCX3 that operate in a bidirectional manner to restore [ Ca ( 2+ ) ] ( i ) to generate Ca ( 2+ ) signals and to *induce* [TNF-a] production . Positive_regulation TNF SLC8A3 23224891 2718512 Our results demonstrate that human macrophages and monocytes express NCX1 and that operate in a bidirectional manner to restore [ Ca ( 2+ ) ] ( i ) to generate Ca ( 2+ ) signals and to *induce* [TNF-a] production . Positive_regulation TNF SLC9A1 19384202 2074954 inhibition also *resulted* in reduced plasma levels of [tumor necrosis factor-alpha] , intercellular adhesion molecule-1 , and C-reactive protein , and attenuated neutrophil infiltration in the liver . Positive_regulation TNF SLPI 17114478 1651569 In this study , we show that , but not S100A4 , was *induced* in 3LL-S cells both in vitro and in vivo by [TNF-alpha] , and that silencing of in vivo induced 3LL-S SLPI expression using RNA interference abrogated in vivo progression but did not influence TNF-alpha resistance . Positive_regulation TNF SLPI 7946401 276754 In addition , we show that interleukin-1 beta and [tumor necrosis factor] *induce* significant expression and are major inducers of elafin/pre-elafin expression . Positive_regulation TNF SMAD3 22237801 2579926 However , disruption of *prevented* angiotensin II-induced kidney injury by lowering albuminuria and serum creatinine ( P < 0.01 ) , inhibiting renal fibrosis such as collagen type I and IV , fibronectin , and a-SMA expression ( all P < 0.01 ) , and blocking renal inflammation including macrophage and T cell infiltration and upregulation of IL-1ß , [TNF-a] , and monocyte chemoattractant protein-1 in vivo and in vitro ( all P < 0.001 ) . Positive_regulation TNF SMAD7 15752249 1379940 Real-time polymerase chain reaction ( PCR ) and immunohistochemistry revealed that gene transfer of *resulted* in a substantial inhibition of interleukin-1beta (IL-1beta) and [tumor necrosis factor alpha (TNFalpha)] expression ( all P < 0.01 vs. control ) . Positive_regulation TNF SMAD7 17384642 1727708 The formation of Smad7-TAB2 and complexes *resulted* in the suppression of [TNF] signaling through the adaptors TRAF2 , TAB2 and/or TAB3 , and TAK1 . Positive_regulation TNF SMARCA4 19556365 2117147 Here , we examined the *role* of , a chromatin remodeling enzyme , in the transcription of [TNF-alpha] and MCP-1 in response to renal ischemia . Positive_regulation TNF SMC3 19509265 2092230 We found that effective blockage of NF-kappaB had no detectable effect on SM compound 3 (SMC3) induced TNF secretion , suggesting that the *induction* of [TNF] by is independent of NF-kappaB . Positive_regulation TNF SMPD1 20236926 2272972 Studies on the *role* of and ceramide in the regulation of tumor necrosis factor alpha (TNFalpha) converting enzyme activity and [TNFalpha] secretion in macrophages . Positive_regulation TNF SMPD2 11311151 804935 These results suggest that ( part of ) the presently identified caveolar activity is *involved* in [TNFalpha] signalling . Positive_regulation TNF SMPD2 12391233 1007317 Furthermore , *activation* of by [TNF] was strongly enhanced when RACK1 , FAN , and a noncytotoxic TNF-R55 mutant were expressed concurrently , suggesting RACK1 as a modulator of N-SMase activation . Positive_regulation TNF SMPD2 14689449 1194513 Both staurosporine and [tumor necrosis factor-alpha (TNF-alpha)] *induced* apoptosis and in a multiphasic manner in both OPC and HOG cells . Positive_regulation TNF SMPD2 17085432 1675739 *Role* for in [tumor necrosis factor] alpha stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells : p38 MAPK is an upstream regulator of nSMase2 . Positive_regulation TNF SMPD2 20080539 2205762 Although *activation* of by the proinflammatory cytokine [TNF] was described almost two decades ago , the underlying signaling pathway is unresolved . Positive_regulation TNF SMPD2 23319743 2742917 We also show that FASN overexpression suppresses [tumor necrosis factor-a] production and nuclear factor-?B activation as well as drug induced *activation* of . Positive_regulation TNF SMPD2 7507110 244524 We found that [TNF-alpha] signaling may *involve* activation of a cell membrane in that within 2.5-5 min of treatment of cells with TNF-alpha there was a 2-fold increase in the activity of N-SMase compared to control . Positive_regulation TNF SMPD3 12566438 1079232 Moreover , [tumor necrosis factor] *induced* approximately 50 % activation of in MCF7 cells overexpressing the enzyme , demonstrating that nSMase2 is a tumor necrosis factor-responsive enzyme . Positive_regulation TNF SMPD3 20080539 2205763 In yeast , the N terminus of EED binds to the catalytic domain of nSMase2 as well as to RACK1 , a protein that modulates the *activation* of by [TNF] in concert with the TNF receptor 1 (TNF-R1) associated protein FAN . Positive_regulation TNF SMS 18785685 2012164 *induced* concentration related increases in [TNF-alpha] and IL-6 production ; Positive_regulation TNF SMURF1 18567580 1946389 We conclude that in chronic inflammatory disorders where TNF is increased , [TNF] *induces* the expression of ubiquitin ligase and promotes ubiquitination and proteasomal degradation of Smad1 and Runx2 , leading to systemic bone loss . Positive_regulation TNF SNAP25 10415049 631177 also suppressed , and L-NMA *enhanced* , expression of [TNF-alpha] , reported to be involved in activation induced NK cell death , in response to CD16 cross linking . Positive_regulation TNF SNAP25 7578978 333358 In addition , *prevented* the potentiation of IL-6 and the inhibition of [TNF-alpha] release by L-NIO . Positive_regulation TNF SNAP25 9038216 415425 However , SNP and did not elevate cGMP levels in U937 cell cultures , and the cGMP analog , 8-bromo-cGMP , *had* no effect on [TNF] production . Positive_regulation TNF SNAP25 9038216 415427 H89 , an inhibitor of cAMP dependent protein kinase , dose dependently increased [TNF] production in phorbol myristate acetate differentiated U937 cells in the absence ( 6.5-fold at 30 microM ; p = 0.035 ) , but not in the *presence* ( p = 0.77 ) of . Positive_regulation TNF SNAP25 9038216 415428 Conversely , the cAMP analog dibutyryl cAMP ( Bt2cAMP ) blocked *induced* [TNF] production ( p = 0.001 ) . Positive_regulation TNF SNAP25 9038216 415429 SNP and ( 500 microM ) *increased* relative [TNF] mRNA levels by 57.5 % ( p = 0.045 ) and 66.2 % ( p = 0.001 ) , respectively . Positive_regulation TNF SNN 16453279 1540706 [TNFalpha] can *induce* mRNA expression in endothelial cells in a PKC-epsilon dependent manner . Positive_regulation TNF SNN 16572589 1543280 We have recently demonstrated in human umbilical vein endothelial cells ( HUVECs ) that gene expression is significantly *induced* by [tumor necrosis factor-alpha (TNF-alpha)] in a protein kinase C-epsilon ( PKC-epsilon ) -dependent manner . Positive_regulation TNF SNN 16572589 1543281 In order to assess how may be *involved* in [TNF-alpha] signaling in HUVEC growth arrest , we performed microarray analysis of TNF-alpha stimulated HUVECs with and without Snn knockdown via siRNA . Positive_regulation TNF SNORA73A 11571294 882330 [TNF-alpha] *induces* 19K-Bax interaction and inhibits Bax oligomerization . Positive_regulation TNF SNORA73A 9060638 417775 We now report that [TNF] induces translocation of cPLA2 from the cytosol to membranes in Ad-infected human A549 cells and that E3-10.4K/14.5K but not E3-14.7K or is *required* to inhibit TNF induced translocation of cPLA2 . Positive_regulation TNF SNORD1A 8495422 219505 The secretions of IL-1 beta , [TNF-alpha] , and -beta , and IFN-gamma *induced* by either or F42K were markedly reduced compared with secretions produced in response to recombinant wild-type IL-2 . Positive_regulation TNF SNRPG 16760141 1572003 also *enhanced* production of [tumor necrosis factor-alpha] in murine macrophages infected with enteropathogenic E. coli ( EPEC ) . Positive_regulation TNF SNRPN 9327338 457247 In both HS and AIDS patients , stimulation with *induced* more IL-1 and [TNF-alpha] release by monocytes compared to SmT . Positive_regulation TNF SOAT1 22121136 2548499 Unexpectedly , although [tumour necrosis factor (TNF)] did not *induce* immediate phosphorylation of either , CP-690,550 inhibited TNF induced expression of several chemokines ( IP-10 , RANTES and MCP1 ) at the messenger RNA and protein levels . Positive_regulation TNF SOCS1 12032139 968174 A further analysis revealed that deficiency *results* in augmented [TNF] signaling via the p38 mitogen activated protein kinase pathway but not NFkappaB or c-Jun N-terminal kinase pathways . Positive_regulation TNF SOCS1 12032139 968176 Therefore , these findings provide evidence that physiological levels of negatively *regulate* [TNF] signaling . Positive_regulation TNF SOCS1 12077274 957059 We show in this work that SOCS1 , SOCS2 , SOCS3 , and cytokine-inducible SH2 containing protein mRNA were up-regulated by IFN-gamma in normal human keratinocytes , whereas only or SOCS1 and cytokine-inducible SH2 containing protein were *induced* by [TNF-alpha] or IL-4 , respectively . Positive_regulation TNF SOCS1 23375208 2747887 was *induced* by IL-4 , IL-13 , IFN-? , and [TNF-a] , while SOCS3 expression was upregulated by IL-6 , IL-13 , IFN-? , and TNF-a . Positive_regulation TNF SOCS3 11014223 736323 Although IL-1/beta and [TNFalpha] alone *induced* only weakly the expression of and CIS , these cytokines strongly potentiated the induction of these two SOCS by GH . Positive_regulation TNF SOCS3 11604392 888229 Strikingly , [TNF-alpha] *induced* a sustained expression , essentially in the WAT . Positive_regulation TNF SOCS3 12817006 1103558 Recently , it has been demonstrated that [TNF-alpha] and LPS *induce* the expression of ( SOCS3 ) and inhibit IL-6 induced STAT3 activation in macrophages . Positive_regulation TNF SOCS3 16925527 1603315 Physiological levels of detected in IL-10 exposed human monocytes *had* no effect on LPS induced [TNF-alpha] production . Positive_regulation TNF SOCS3 23375208 2747888 SOCS1 was *induced* by IL-4 , IL-13 , IFN-? , and [TNF-a] , while expression was upregulated by IL-6 , IL-13 , IFN-? , and TNF-a . Positive_regulation TNF SOCS3 23853585 2816997 Instead , expression in infected macrophages and DCs *prevented* the IL-6 mediated inhibition of [TNF] and IL-12 secretion and contributed to a timely CD4+ cell dependent IFN-? expression in vivo . Positive_regulation TNF SOD1 10760955 683692 Expression of the manganese ( Mn-SOD ) is *induced* by [tumor necrosis factor-alpha (TNF-alpha)] , interleukin-1 (IL-1) , and lipopolysaccharide (LPS) . Positive_regulation TNF SOD1 11675473 873396 In summary , [TNFalpha] *induces* expression in human ESC . Positive_regulation TNF SOD1 1320006 190074 [Tumor necrosis factor-alpha] activates nuclear factor kappa B and *induces* manganous and phosphodiesterase mRNA in human papillary thyroid carcinoma cells . Positive_regulation TNF SOD1 1668725 177708 [TNF-alpha] *induces* manganese containing ( MnSOD ) which also uses O2- to produce cytotoxic concentrations of hydrogen peroxide . Positive_regulation TNF SOD1 18761070 1975441 Pretreatment with CGX significantly restored the reduction of catalase activity and glutathione ( GSH ) content , but not activity , and it *inhibited* the CCl ( 4 ) -induced high expression of iNOS and [TNF-alpha] in hepatic tissue . Positive_regulation TNF SOD1 20112906 2206330 and GPx expressions decreased ( p < 0.001 ) but that of [TNFalpha] *increased* significantly ( P < 0.001 ) in FT rats with respect to FC and NFT animals . Positive_regulation TNF SOD1 20824052 2318551 Short interfering RNA ( siRNA ) -mediated knockdown of one of the photoaffinity labeled proteins , , an ROS scavenger , *resulted* in an increase in [tumor necrosis factor-alpha] production by RAW 264.7 cells in response to DMXAA compared with negative or positive controls transfected with nontargeting or lamin A/C targeting siRNA molecules , respectively . Positive_regulation TNF SOD1 21040696 2376296 After edaravone treatment , levels of MDA , IL-6 , [TNF-a] and hydroproline decreased , but and GSH-PX activity in lung tissue and BALF *increased* . Positive_regulation TNF SOD1 22985554 2674276 Compared with those in LPS group , IL-1ß , IL-6 , [TNF-a] and MDA in BALF , W/D , lung injury scores and iNOS mRNA and protein expression were significantly reduced and in the BALF significantly *increased* in LPS+DAS group . Positive_regulation TNF SOD1 23895132 2825682 However , comparing to the model rabbits , levels of [TNF-a] , IL-1ß and MDA decreased significantly and serum activity *increased* , gene and protein expressions of E-sel , ICAM-1 , VCAM-1 and MCP-1 in aortas decreased significantly with the treatment of kaempferol . Positive_regulation TNF SOD1 2547375 115564 [TNF] *induced* more mitochondrial manganese ( SODm ) in MCF-7 than in Tnf-1000 whereas there appeared to be no significant induction of cytosolic copper/zinc SOD ( SODc ) by TNF in both MCF-7 and Tnf-1000 cell lines . Positive_regulation TNF SOD1 7760346 307923 Leukemia inhibitory factor and [tumor necrosis factor] *induce* manganese and protect rabbit hearts from reperfusion injury . Positive_regulation TNF SOD1 8406994 233106 These data suggest that , in vivo , the [TNF alpha] and IL-1 alpha produced by cancer cells and other cells may *induce* in vascular endothelial cells as well as other host tissues , resulting in release of a relatively large amount of this protein into the serum . Positive_regulation TNF SOD1 8440412 213312 Interleukin-1 (IL-1) and [tumor necrosis factor (TNF)] selectively *induce* mitochondrial manganese ( MnSOD ) production in various cell types . Positive_regulation TNF SOD1 8568353 340630 These data suggest that in vivo the [TNF-alpha] produced by cancer cells may *induce* in vascular endothelial cells , resulting in release of a relatively large amount of this protein into the serum . Positive_regulation TNF SOD1 9038369 415547 [TNF-alpha] rapidly *induced* gene expression while IL-1beta was a strong but slow inducer of this gene . Positive_regulation TNF SOD1 9062943 418024 [tumor necrosis factor] *induces* expression of a Ca ( 2+ ) -binding protein and ; Positive_regulation TNF SOD2 10760955 683693 Expression of the manganese superoxide dismutase ( ) is *induced* by [tumor necrosis factor-alpha (TNF-alpha)] , interleukin-1 (IL-1) , and lipopolysaccharide (LPS) . Positive_regulation TNF SOD2 11675473 873397 In summary , [TNFalpha] *induces* expression in human ESC . Positive_regulation TNF SOD2 1320006 190075 [Tumor necrosis factor-alpha] activates nuclear factor kappa B and *induces* manganous and phosphodiesterase mRNA in human papillary thyroid carcinoma cells . Positive_regulation TNF SOD2 1668725 177709 [TNF-alpha] *induces* manganese containing ( MnSOD ) which also uses O2- to produce cytotoxic concentrations of hydrogen peroxide . Positive_regulation TNF SOD2 18761070 1975442 Pretreatment with CGX significantly restored the reduction of catalase activity and glutathione ( GSH ) content , but not activity , and it *inhibited* the CCl ( 4 ) -induced high expression of iNOS and [TNF-alpha] in hepatic tissue . Positive_regulation TNF SOD2 20112906 2206331 and GPx expressions decreased ( p < 0.001 ) but that of [TNFalpha] *increased* significantly ( P < 0.001 ) in FT rats with respect to FC and NFT animals . Positive_regulation TNF SOD2 21040696 2376297 After edaravone treatment , levels of MDA , IL-6 , [TNF-a] and hydroproline decreased , but and GSH-PX activity in lung tissue and BALF *increased* . Positive_regulation TNF SOD2 22985554 2674277 Compared with those in LPS group , IL-1ß , IL-6 , [TNF-a] and MDA in BALF , W/D , lung injury scores and iNOS mRNA and protein expression were significantly reduced and in the BALF significantly *increased* in LPS+DAS group . Positive_regulation TNF SOD2 23895132 2825683 However , comparing to the model rabbits , levels of [TNF-a] , IL-1ß and MDA decreased significantly and serum activity *increased* , gene and protein expressions of E-sel , ICAM-1 , VCAM-1 and MCP-1 in aortas decreased significantly with the treatment of kaempferol . Positive_regulation TNF SOD2 2547375 115565 [TNF] *induced* more mitochondrial manganese ( SODm ) in MCF-7 than in Tnf-1000 whereas there appeared to be no significant induction of cytosolic copper/zinc SOD ( SODc ) by TNF in both MCF-7 and Tnf-1000 cell lines . Positive_regulation TNF SOD2 7760346 307924 Leukemia inhibitory factor and [tumor necrosis factor] *induce* manganese and protect rabbit hearts from reperfusion injury . Positive_regulation TNF SOD2 8406994 233107 These data suggest that , in vivo , the [TNF alpha] and IL-1 alpha produced by cancer cells and other cells may *induce* in vascular endothelial cells as well as other host tissues , resulting in release of a relatively large amount of this protein into the serum . Positive_regulation TNF SOD2 8440412 213313 Interleukin-1 (IL-1) and [tumor necrosis factor (TNF)] selectively *induce* mitochondrial manganese ( MnSOD ) production in various cell types . Positive_regulation TNF SOD2 8568353 340631 These data suggest that in vivo the [TNF-alpha] produced by cancer cells may *induce* in vascular endothelial cells , resulting in release of a relatively large amount of this protein into the serum . Positive_regulation TNF SOD2 9038369 415548 [TNF-alpha] rapidly *induced* gene expression while IL-1beta was a strong but slow inducer of this gene . Positive_regulation TNF SOD2 9062943 418025 [tumor necrosis factor] *induces* expression of a Ca ( 2+ ) -binding protein and ; Positive_regulation TNF SOD3 10760955 683694 Expression of the manganese ( Mn-SOD ) is *induced* by [tumor necrosis factor-alpha (TNF-alpha)] , interleukin-1 (IL-1) , and lipopolysaccharide (LPS) . Positive_regulation TNF SOD3 11675473 873398 In summary , [TNFalpha] *induces* expression in human ESC . Positive_regulation TNF SOD3 1320006 190076 [Tumor necrosis factor-alpha] activates nuclear factor kappa B and *induces* manganous and phosphodiesterase mRNA in human papillary thyroid carcinoma cells . Positive_regulation TNF SOD3 1668725 177710 [TNF-alpha] *induces* manganese containing ( MnSOD ) which also uses O2- to produce cytotoxic concentrations of hydrogen peroxide . Positive_regulation TNF SOD3 18761070 1975443 Pretreatment with CGX significantly restored the reduction of catalase activity and glutathione ( GSH ) content , but not activity , and it *inhibited* the CCl ( 4 ) -induced high expression of iNOS and [TNF-alpha] in hepatic tissue . Positive_regulation TNF SOD3 20112906 2206332 and GPx expressions decreased ( p < 0.001 ) but that of [TNFalpha] *increased* significantly ( P < 0.001 ) in FT rats with respect to FC and NFT animals . Positive_regulation TNF SOD3 21040696 2376298 After edaravone treatment , levels of MDA , IL-6 , [TNF-a] and hydroproline decreased , but and GSH-PX activity in lung tissue and BALF *increased* . Positive_regulation TNF SOD3 22985554 2674278 Compared with those in LPS group , IL-1ß , IL-6 , [TNF-a] and MDA in BALF , W/D , lung injury scores and iNOS mRNA and protein expression were significantly reduced and in the BALF significantly *increased* in LPS+DAS group . Positive_regulation TNF SOD3 23895132 2825684 However , comparing to the model rabbits , levels of [TNF-a] , IL-1ß and MDA decreased significantly and serum activity *increased* , gene and protein expressions of E-sel , ICAM-1 , VCAM-1 and MCP-1 in aortas decreased significantly with the treatment of kaempferol . Positive_regulation TNF SOD3 2547375 115566 [TNF] *induced* more mitochondrial manganese ( SODm ) in MCF-7 than in Tnf-1000 whereas there appeared to be no significant induction of cytosolic copper/zinc SOD ( SODc ) by TNF in both MCF-7 and Tnf-1000 cell lines . Positive_regulation TNF SOD3 7760346 307925 Leukemia inhibitory factor and [tumor necrosis factor] *induce* manganese and protect rabbit hearts from reperfusion injury . Positive_regulation TNF SOD3 8406994 233108 These data suggest that , in vivo , the [TNF alpha] and IL-1 alpha produced by cancer cells and other cells may *induce* in vascular endothelial cells as well as other host tissues , resulting in release of a relatively large amount of this protein into the serum . Positive_regulation TNF SOD3 8440412 213314 Interleukin-1 (IL-1) and [tumor necrosis factor (TNF)] selectively *induce* mitochondrial manganese ( MnSOD ) production in various cell types . Positive_regulation TNF SOD3 8568353 340632 These data suggest that in vivo the [TNF-alpha] produced by cancer cells may *induce* in vascular endothelial cells , resulting in release of a relatively large amount of this protein into the serum . Positive_regulation TNF SOD3 9038369 415549 [TNF-alpha] rapidly *induced* gene expression while IL-1beta was a strong but slow inducer of this gene . Positive_regulation TNF SOD3 9062943 418026 [tumor necrosis factor] *induces* expression of a Ca ( 2+ ) -binding protein and ; Positive_regulation TNF SOST 19292615 2114392 Significantly , TWEAK and [TWEAK/TNF] *induced* the expression of the osteoblast differentiation inhibitor and gene product , sclerostin . Positive_regulation TNF SP1 10636866 660075 binding is *critical* for promoter assembly and activation of the MCP-1 gene by [tumor necrosis factor] . Positive_regulation TNF SP1 10913190 716208 The transcription factors ATF-2 , c-jun , Egr-1 , and are also inducibly recruited to the TNF-alpha promoter in vivo , and the binding sites for each of these activators are *required* for LPS stimulated [TNF-alpha] gene expression . Positive_regulation TNF SP1 7649977 319158 Importantly , [TNF] *induced* the association between p53 and in Jurkat T cells . Positive_regulation TNF SP4 7497530 335852 Separated mononuclear cells also produced significant levels of [TNF] in *response* to SP and . Positive_regulation TNF SP4 7497530 335854 Anti-TNF-alpha antibodies neutralized the [TNF] *induced* by in plasma . Positive_regulation TNF SPG11 15312003 1285144 However , *increased* [TNF-] release into the perfusate after reperfusion . Positive_regulation TNF SPG14 15312003 1285147 However , *increased* [TNF-] release into the perfusate after reperfusion . Positive_regulation TNF SPG16 15312003 1285148 However , *increased* [TNF-] release into the perfusate after reperfusion . Positive_regulation TNF SPG18 15312003 1285150 However , *increased* [TNF-] release into the perfusate after reperfusion . Positive_regulation TNF SPG19 15312003 1285149 However , *increased* [TNF-] release into the perfusate after reperfusion . Positive_regulation TNF SPG20 15312003 1285151 However , *increased* [TNF-] release into the perfusate after reperfusion . Positive_regulation TNF SPG21 15312003 1285152 However , *increased* [TNF-] release into the perfusate after reperfusion . Positive_regulation TNF SPG23 15312003 1285153 However , *increased* [TNF-] release into the perfusate after reperfusion . Positive_regulation TNF SPG24 15312003 1285154 However , *increased* [TNF-] release into the perfusate after reperfusion . Positive_regulation TNF SPG25 15312003 1285155 However , *increased* [TNF-] release into the perfusate after reperfusion . Positive_regulation TNF SPG27 15312003 1285156 However , *increased* [TNF-] release into the perfusate after reperfusion . Positive_regulation TNF SPG29 15312003 1285157 However , *increased* [TNF-] release into the perfusate after reperfusion . Positive_regulation TNF SPG32 15312003 1285158 However , *increased* [TNF-] release into the perfusate after reperfusion . Positive_regulation TNF SPG34 15312003 1285159 However , *increased* [TNF-] release into the perfusate after reperfusion . Positive_regulation TNF SPG36 15312003 1285160 However , *increased* [TNF-] release into the perfusate after reperfusion . Positive_regulation TNF SPG37 15312003 1285161 However , *increased* [TNF-] release into the perfusate after reperfusion . Positive_regulation TNF SPG38 15312003 1285162 However , *increased* [TNF-] release into the perfusate after reperfusion . Positive_regulation TNF SPG41 15312003 1285163 However , *increased* [TNF-] release into the perfusate after reperfusion . Positive_regulation TNF SPG45 15312003 1285164 However , *increased* [TNF-] release into the perfusate after reperfusion . Positive_regulation TNF SPG56 15312003 1285165 However , *increased* [TNF-] release into the perfusate after reperfusion . Positive_regulation TNF SPG7 15312003 1285145 However , *increased* [TNF-] release into the perfusate after reperfusion . Positive_regulation TNF SPG9 15312003 1285146 However , *increased* [TNF-] release into the perfusate after reperfusion . Positive_regulation TNF SPHK1 10567432 567725 *Activation* of by [tumor necrosis factor-alpha] inhibits apoptosis in human endothelial cells . Positive_regulation TNF SPHK1 10567432 567731 Thus , we demonstrate that the *activation* of by [TNF] is an important signaling for protection from the apoptotic effect of TNF in endothelial cells . Positive_regulation TNF SPHK1 10944534 744120 *Activation* of endogenous SK activity by [tumor necrosis factor-alpha (TNFalpha)] , interleukin-1beta , and phorbol esters in HEK293T cells was blocked by expression of this inactive ( hSK ( G82D ) ) . Positive_regulation TNF SPHK1 15855330 1400112 Compared with basal values , IL-1beta and [TNF-alpha] *induced* increases in mRNA levels relative to 18S ribosomal RNA in INS-1 cells within 1 h ; Positive_regulation TNF SPHK1 15855330 1400117 IL-1beta , but not [TNF-alpha] , *induced* relative mRNA expression levels within 1 h in islets , whereas SPHK2 mRNA levels were unchanged . Positive_regulation TNF SPHK1 15855330 1400123 Thus , IL-1beta and [TNF-alpha] *induced* an early and sustained increase in activity in INS-1 cells and isolated islets , suggesting that S1P plays a role in the pathological response of pancreatic beta-cells to cytokines . Positive_regulation TNF SPHK1 16278291 1502528 Furthermore , experiments using SphK1 specific siRNA demonstrated that is *required* for the [TNF-alpha] stimulation of MMP1 . Positive_regulation TNF SPHK1 17114809 1677170 However , RhoA activation by [TNF-alpha] was not *blocked* by inhibition . Positive_regulation TNF SPHK1 17306937 1705218 Dimethylsphingosine , an inhibitor of , partially *inhibited* [TNF-alpha] induction of IL-8 mRNA levels indicating the importance of intracellular increases in S1-P in the IL-8 induction . Positive_regulation TNF SPHK1 20036321 2200444 Suppression of by its inhibitor , N , N Dimethylsphingosine ( DMS ) , or siRNA *resulted* in decreased mRNA expression of [TNF-alpha] , IL-1beta , and iNOS and release of TNF-alpha and nitric oxide ( NO ) in LPS activated microglia . Positive_regulation TNF SPHK1 20577214 2280425 These results also highlight the key *role* of and its product S1P in [TNF-alpha] signalling and the canonical NF-kappaB activation pathway important in inflammatory , antiapoptotic and immune processes . Positive_regulation TNF SPHK2 10567432 567726 *Activation* of by [tumor necrosis factor-alpha] inhibits apoptosis in human endothelial cells . Positive_regulation TNF SPHK2 10567432 567732 Thus , we demonstrate that the *activation* of by [TNF] is an important signaling for protection from the apoptotic effect of TNF in endothelial cells . Positive_regulation TNF SPHK2 10944534 744121 *Activation* of endogenous SK activity by [tumor necrosis factor-alpha (TNFalpha)] , interleukin-1beta , and phorbol esters in HEK293T cells was blocked by expression of this inactive ( hSK ( G82D ) ) . Positive_regulation TNF SPHK2 15855330 1400118 IL-1beta , but not [TNF-alpha] , *induced* relative SPHK1a mRNA expression levels within 1 h in islets , whereas mRNA levels were unchanged . Positive_regulation TNF SPHK2 15855330 1400124 Thus , IL-1beta and [TNF-alpha] *induced* an early and sustained increase in activity in INS-1 cells and isolated islets , suggesting that S1P plays a role in the pathological response of pancreatic beta-cells to cytokines . Positive_regulation TNF SPHK2 17114809 1677171 However , RhoA activation by [TNF-alpha] was not *blocked* by inhibition . Positive_regulation TNF SPHK2 17306937 1705219 Dimethylsphingosine , an inhibitor of , partially *inhibited* [TNF-alpha] induction of IL-8 mRNA levels indicating the importance of intracellular increases in S1-P in the IL-8 induction . Positive_regulation TNF SPN 10899905 712452 expression by the M ( phi ) was also *required* for optimal induction by M. avium of [tumor necrosis factor (TNF)-alpha] production , which likewise could be reconstituted by Galgp . Positive_regulation TNF SPN 9638335 513956 Although [TNF] did not *induce* significant modification of expression on suspended cells , we showed that 40 % of membrane CD43 is released during neutrophil TNF induced adhesion to serum coated plates or endothelial cells , and that migration through the endothelial monolayer did not result in further shedding . Positive_regulation TNF SPP1 15855273 1432683 *induces* their Th1 promoting [tumor necrosis factor alpha (TNF-alpha)] and interleukin-12 (IL-12) secretion , and enhances their allostimulatory capacity . Positive_regulation TNF SPP1 17444956 1729829 increased CD69 and CD25 expression and *enhanced* T-cell IFN-gamma and [TNF-alpha] production in a dose dependent fashion with higher levels in CD than in healthy controls ( HC ) , but induced a concomitant higher IL-10 production in HC than CD . Positive_regulation TNF SPP1 19076536 2024211 On the contrary , *induced* IFN-gamma , IL-4 , IL-5 , IL-13 , IL-1beta , and [TNF-alpha] production in sinonasal mucosa . Positive_regulation TNF SPP1 23416968 2748872 Using neutralizing antibody and recombinant cytokines , we found that overexpressed by tumor cells *regulates* the production of [TNF-a] and IL-10 by monocytes partly via MCP-1 and TGF-ß1 , respectively . Positive_regulation TNF SPP1 7785911 309926 Since can be *induced* in macrophages by [TNF-alpha] stimulation and since on the other hand osteopontin appears to decrease the level of nitric oxide synthase , and thus the production of nitric oxide , osteopontin might also indirectly have an antifibrotic effect . Positive_regulation TNF SPP1 9324065 456614 Moreover , *had* a significant effect on anti-DNP IgE induced histamine release or [tumor necrosis factor-alpha] production from RPMC . Positive_regulation TNF SPP1 9610617 508779 To investigate whether MCP-1 , CINC , RANTES , and ICAM-1 mRNA could be *induced* in cultured rat mesangial cells by interleukin-1beta(IL-1beta) , [tumor necrosis factor-alpha (TNF-alpha)] and lipopolysaccharide (LPS) , and whether MCP-1 and CINC gene expression could be modulated by dexamethasone , Northern blot assays were performed . Positive_regulation TNF SPP2 9324065 456615 Moreover , *had* a significant effect on anti-DNP IgE induced histamine release or [tumor necrosis factor-alpha] production from RPMC . Positive_regulation TNF SPRR1B 18172072 1855835 IL1alpha , IL1beta , IL6 , IFNgamma , and [TNFalpha] *induced* expression in vitro and the local expression of IL1beta and IFNgamma was elevated in ocular tissues of patients with SS and aire-deficient mice . Positive_regulation TNF SQSTM1 11438547 843381 Although the *role* of receptor in [TNF] signaling is well established , the role of p80 is less clear . Positive_regulation TNF SQSTM1 20337701 2273166 Mouse macrophage RAW264.7 cells produced [tumor necrosis factor (TNF)-alpha] in *response* to stimulation with recombinant . Positive_regulation TNF SRC 11832448 910230 *Activation* of by [TNF-alpha] led to reduced E-cadherin levels and enhanced invasion of src transfectants . Positive_regulation TNF SRC 12707358 1082849 A protein kinase C ( PKC ) inhibitor ( staurosporine ) , tyrosine kinase inhibitors ( genistein and herbimycin A ) , or a kinase inhibitor ( PP2 ) *attenuated* [TNF-alpha-] or 12-O-tetradecanoylphorbol-13-acetate ( TPA ) -induced COX-2 promoter activity . Positive_regulation TNF SRC 17934341 1813474 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not , JNK , nor p38 MAPK . Positive_regulation TNF SRC 19778233 2141046 The induction of [TNF-alpha] and TGF-beta1 by silica was *suppressed* by inhibitor ( PP1 ) , ERK inhibitor ( PD98059 ) , but not by p38 kinase inhibitor ( SB203580 ) . Positive_regulation TNF SRC 21354239 2431661 Pharmacological studies revealed that the integrity of lipid raft and the activation of , Ras , Raf , ERK , and NF-?B all *contributed* to JEV induced [TNF-a] and IL-1ß expression . Positive_regulation TNF SRC 23639811 2805068 We now extend these studies into mouse models to evaluate the contribution of hepatocytes to the NOX- and *dependent* [TNF-a] production that follows H/R in primary hepatocytes and liver ischemia-reperfusion ( I/R ) . Positive_regulation TNF SRC 9792645 542585 [Tumor necrosis factor-alpha] activation of nuclear transcription factor-kappaB in marrow macrophages is *mediated* by tyrosine phosphorylation of Ikappa Balpha . Positive_regulation TNF SRGN 11244505 792322 Here , we show that in HeLa cells [TNFalpha] *induces* expression of in an NF-kappaB dependent fashion . Positive_regulation TNF SRM 16360300 1566920 AMs were exposed in vitro to Standard Reference Material (SRM) DEP 2975 , SRM DEP 1650 , 1975 ( a dichloromethane extract of SRM DEP 2975 ) and CB particles for 24 h. DEPs *induced* a decreased secretion of IL-8 , [TNF-alpha] and PGE ( 2 ) in response to a subsequent LPS stimulation . Positive_regulation TNF SRP14 19228095 2039912 and PDT *had* similar effects on crevicular [TNF-alpha] and RANKL levels in patients with aggressive periodontitis . Positive_regulation TNF SRP19 19228095 2039913 and PDT *had* similar effects on crevicular [TNF-alpha] and RANKL levels in patients with aggressive periodontitis . Positive_regulation TNF SRP54 19228095 2039914 and PDT *had* similar effects on crevicular [TNF-alpha] and RANKL levels in patients with aggressive periodontitis . Positive_regulation TNF SRP68 19228095 2039915 and PDT *had* similar effects on crevicular [TNF-alpha] and RANKL levels in patients with aggressive periodontitis . Positive_regulation TNF SRP72 19228095 2039916 and PDT *had* similar effects on crevicular [TNF-alpha] and RANKL levels in patients with aggressive periodontitis . Positive_regulation TNF SRP9 19228095 2039917 and PDT *had* similar effects on crevicular [TNF-alpha] and RANKL levels in patients with aggressive periodontitis . Positive_regulation TNF SRSF1 7536422 297245 ELISA and RT-PCR studies revealed that *induced* IL-6 and [tumor necrosis factor (TNF)-alpha] in brain cultures ; Positive_regulation TNF SSB 11046070 742867 Anti-SSA/Ro and autoantibodies bind the surface of apoptotic fetal cardiocytes and *promote* secretion of [TNF-alpha] by macrophages . Positive_regulation TNF SSR1 17845214 1795623 We found that pretreatment of human keratinocytes with PL inhibited mediated *increase* of [tumor necrosis factor (TNF)-alpha] and also abrogated nitric oxide ( NO ) production . Positive_regulation TNF SSR2 17845214 1795624 We found that pretreatment of human keratinocytes with PL inhibited *mediated* increase of [tumor necrosis factor (TNF)-alpha] and also abrogated nitric oxide ( NO ) production . Positive_regulation TNF SSR3 17845214 1795625 We found that pretreatment of human keratinocytes with PL inhibited mediated *increase* of [tumor necrosis factor (TNF)-alpha] and also abrogated nitric oxide ( NO ) production . Positive_regulation TNF SSR4 17845214 1795626 We found that pretreatment of human keratinocytes with PL inhibited *mediated* increase of [tumor necrosis factor (TNF)-alpha] and also abrogated nitric oxide ( NO ) production . Positive_regulation TNF SST 8982099 403808 The [TNF alpha] production was *stimulated* by NPY and in young subjects , and by NPY , somatostatin and VIP in old ones , whereas GRP produced a decrease of TNF alpha in young persons . Positive_regulation TNF ST13 2809197 121390 *induces* [tumor necrosis factor] and IL-1 secretion by human monocytes . Positive_regulation TNF ST13 2809197 121392 *stimulated* the secretion of [TNF] and IL-1 in a dose dependent manner . Positive_regulation TNF ST3GAL1 17142966 1653792 [TNFalpha] stimulation *induced* the biphasic increases in expression of NFkappaB-p65 , , FUT IV , ST3Gal IV and ST6GalNAc III mRNAs and the transient increase in expression of ST6Gal I mRNA and the decrease in ST3GalNAc IV mRNA . Positive_regulation TNF ST3GAL4 11792769 901959 At 6 mo , *stimulated* PMØ [TNF-alpha] synthesis was significantly higher in patients treated with TBL compared with those treated with LPD ( P = 0.0035 ) . Positive_regulation TNF ST3GAL4 11999343 939609 In islets of C57BL/6 mice of both genders similarly *stimulated* production of IFN-gamma and [TNF-alpha] , but significantly reduced IL-4 and IL-10 levels in male mice only . Positive_regulation TNF ST3GAL4 17142966 1653793 [TNFalpha] stimulation *induced* the biphasic increases in expression of NFkappaB-p65 , ST3Gal I , FUT IV , and ST6GalNAc III mRNAs and the transient increase in expression of ST6Gal I mRNA and the decrease in ST3GalNAc IV mRNA . Positive_regulation TNF ST3GAL4 23442845 2749174 We also showed that *increased* [TNF-a] levels in the hippocampus of mice . Positive_regulation TNF ST3GAL4 24099577 2888775 [TNF] *induces* the expression of the sialyltransferase in human bronchial mucosa via MSK1/2 protein kinases and increases FliD/sialyl-Lewis ( x ) -mediated adhesion of Pseudomonas aeruginosa . Positive_regulation TNF ST3GAL4 24374093 2911721 Further experiments showed that the *induced* protein levels of [tumor necrosis factor-alpha (TNF-alpha)] , Fas , activated caspase-8 and caspase-3 were significantly inhibited by the GABA tea treatment . Positive_regulation TNF ST6GALNAC3 17142966 1653795 [TNFalpha] stimulation *induced* the biphasic increases in expression of NFkappaB-p65 , ST3Gal I , FUT IV , ST3Gal IV and mRNAs and the transient increase in expression of ST6Gal I mRNA and the decrease in ST3GalNAc IV mRNA . Positive_regulation TNF ST8SIA2 11292071 800831 In this study , we investigated whether CV6209 , a PAF antagonist , could modulate *induced* [TNF-alpha] production in human monocytic cells . Positive_regulation TNF ST8SIA2 11292071 800832 CV6209 significantly suppressed *induced* [TNF-alpha] production in a dose- and time dependent manner . Positive_regulation TNF ST8SIA2 11292071 800833 Reverse transcription-polymerase chain reaction ( RT-PCR ) analysis showed that CV6209 suppressed *mediated* [TNF-alpha] mRNA expression . Positive_regulation TNF ST8SIA2 11292071 800834 Our results indicated that CV6209 had an important regulatory effect on *induced* [TNF-alpha] production and gene expression . Positive_regulation TNF ST8SIA2 12384353 998631 In Stx injected mice , azithromycin significantly suppressed *induced* [TNF-alpha] , IL-1beta , and IL-6 levels in serum and improved the outcome as assessed by survival rate . Positive_regulation TNF STAG1 8039914 266649 The ability of to *induce* [TNF-alpha] , encoded by a subset of LPS-inducible genes , and tyrosine phosphoproteins was not affected by LPS inhibitors , confirming that the macrophage response to the parasite extract could not be attributed to LPS contamination . Positive_regulation TNF STAG2 8039914 266650 The ability of to *induce* [TNF-alpha] , encoded by a subset of LPS-inducible genes , and tyrosine phosphoproteins was not affected by LPS inhibitors , confirming that the macrophage response to the parasite extract could not be attributed to LPS contamination . Positive_regulation TNF STAG3 8039914 266651 The ability of to *induce* [TNF-alpha] , encoded by a subset of LPS-inducible genes , and tyrosine phosphoproteins was not affected by LPS inhibitors , confirming that the macrophage response to the parasite extract could not be attributed to LPS contamination . Positive_regulation TNF STAP2 24733425 2939059 Intriguingly , also *regulates* production of proinflammatory chemokines and cytokines such as CXCL1 and [TNF-a] from intestinal epithelial cells . Positive_regulation TNF STAT1 11835405 911414 Here , we report our investigation of the *role* of in [TNF] signaling using STAT1-deficient U3A and STAT1-stably transfected U3A-PSG91 cells . Positive_regulation TNF STAT1 12219013 986601 The 2 groups of mice were analyzed for serum levels of interferon-gamma , [tumor necrosis factor-alpha] , and interleukin-1beta as well as *activation* of NFkappaB and , 2 proinflammatory transcription factors . Positive_regulation TNF STAT1 16635351 1552727 and STAT3 might be *involved* in the regulation of TNF-alpha gene expression , but not in [TNF-alpha] early release ( < 24 hours ) induced by HMGB1 stimulation in rat peritoneal macrophages . Positive_regulation TNF STAT1 16648019 1553292 We hypothesized that [tumor necrosis factor (TNF)-alpha] would *induce* and STAT3 , and PYY would attenuate their transcription factor binding . Positive_regulation TNF STAT1 17878383 1797029 Activation of NF-kappaB , STAT6 , and was *induced* in eosinophils by [TNF-alpha] , IL-4 , and IFN-gamma , respectively . Positive_regulation TNF STAT1 18678606 1973296 Consistent with these results , [TNF-alpha] and PGE2 did not *induce* DNA binding to a standard Stat1 binding oligonucleotide . Positive_regulation TNF STAT1 20006573 2199870 Concomitantly , [TNFalpha] *induced* phosphorylation of at Tyr-701 by JAK1 facilitates its nuclear translocation and activation of CD40 through p300 recruitment and core Histone-3 acetylation . Positive_regulation TNF STAT1 20523058 2271279 Cooperative *activation* of CCL5 expression by TLR3 and [tumor necrosis factor-alpha] or interferon-gamma through nuclear factor-kappaB or in airway epithelial cells . Positive_regulation TNF STAT1 22121136 2548501 [TNF] *induced* early interferon ( IFN ) ß expression and phosphorylation beginning at 3 h , which was blocked by CP-690,550 . Positive_regulation TNF STAT1 23170143 2700347 Recent studies have shown that cerulein activated nicotinamide adenine dinucleotide phosphate oxidase elicits reactive oxygen species , which trigger the phosphorylation of the JAK1 , , and STAT3 proteins and *induce* the production of inflammatory cytokines , such as [tumor necrosis factor-a] , interleukin (IL)-1ß , and IL-6 , in pancreatic acinar cells . Positive_regulation TNF STAT1 8940176 399120 [Tumor necrosis factor-alpha] and interferon-gamma *induced* NF-kappaB ( p50/p65 ) and , respectively , as assessed by gel shift assays . Positive_regulation TNF STAT3 10347215 616823 Herein , we demonstrate that the ability of IL-10 to inhibit [tumor necrosis factor alpha (TNFalpha)] production in lipopolysaccharide stimulated macrophages *requires* the presence of , Jak1 , and two distinct regions of the IL-10 receptor intracellular domain . Positive_regulation TNF STAT3 10616907 575883 We report that [TNF] induces DNA replication in growth arrested LE6 cells and that its effect *involves* the activation of NFkappaB and and an increase in c-myc and IL-6 mRNAs . Positive_regulation TNF STAT3 10728791 678203 At least four transcription factors , NFkappaB , ( which are strongly *induced* by [TNF] ) , AP-1 and C/EBPbeta play major roles in the initiation of liver regeneration . Positive_regulation TNF STAT3 16635351 1552728 STAT1 and might be *involved* in the regulation of TNF-alpha gene expression , but not in [TNF-alpha] early release ( < 24 hours ) induced by HMGB1 stimulation in rat peritoneal macrophages . Positive_regulation TNF STAT3 16648019 1553293 We hypothesized that [tumor necrosis factor (TNF)-alpha] would *induce* STAT1 and , and PYY would attenuate their transcription factor binding . Positive_regulation TNF STAT3 17302908 1699001 activated by LPS did not directly *regulate* inhibitor of kappa B alpha ( IkappaBalpha ) activation or [tumour necrosis factor (TNF)-alpha] production , a process dependent on the transcriptional activity of nuclear factor kappa B (NFkappaB) , although the transcriptional activity of STAT3 contributed to the mechanism by which interleukin (IL)-10 suppressed LPS induced TNF-alpha levels . Positive_regulation TNF STAT3 17302908 1699003 These results indicate that activation can not directly *regulate* LPS signalling in human monocytes and represents only part of the mechanism by which IL-10 suppresses [TNF-alpha] production by activated human monocytes . Positive_regulation TNF STAT3 20205746 2229744 [TNF-alpha] *induced* phosphorylation of . Positive_regulation TNF STAT3 22506067 2583963 *regulates* monocyte [TNF-alpha] production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass . Positive_regulation TNF STAT3 23170143 2700348 Recent studies have shown that cerulein activated nicotinamide adenine dinucleotide phosphate oxidase elicits reactive oxygen species , which trigger the phosphorylation of the JAK1 , STAT1 , and proteins and *induce* the production of inflammatory cytokines , such as [tumor necrosis factor-a] , interleukin (IL)-1ß , and IL-6 , in pancreatic acinar cells . Positive_regulation TNF STAT3 23862224 2817452 [TNF-alpha] + CAPE *induced* statistically lower expressions of IL-6 and than TNF-alpha alone ( P < 0.05 ) . Positive_regulation TNF STAT3 23942241 2827175 Instead , C3a induces retina regeneration via activation , which in turn *activates* the injury- and inflammation-responsive factors , IL-6 , IL-8 and [TNF-a] . Positive_regulation TNF STAT3 23971732 2841246 In this study , we have identified a link between brain inflammation and the signal transducer and activator of transcription 3 ( STAT3 ) pathway : IL-1ß and [TNF-a] *induce* activation in NPCs . Positive_regulation TNF STAT5A 14625478 1170221 The changes in cytokine profiles after burn , particularly interleukin-1beta and macrophage inhibitory factor , appear to be mediated by C/EBP-beta and STAT-3 , whereas after the induction of a sepsis , [tumor necrosis factor] and interleukin-6 are mainly *mediated* by . Positive_regulation TNF STAT5A 15086448 1234703 Staining of the ganglionic cells with an antibody against the transcription factor STAT5 revealed that [TNF-alpha] *induced* a nuclear translocation of in non-neuronal cells . Positive_regulation TNF STAT6 11254707 794139 [TNF-alpha] inducibility of the IL-8 and monocyte chemoattractant protein-1 genes was not *dependent* on expression in the same experimental systems . Positive_regulation TNF STAT6 17878383 1797030 Activation of NF-kappaB , , and STAT1 was *induced* in eosinophils by [TNF-alpha] , IL-4 , and IFN-gamma , respectively . Positive_regulation TNF STEAP4 18430367 1900139 The expression was *induced* by [TNF-alpha] in a dose dependent manner in human adipose tissue . Positive_regulation TNF STEAP4 18430367 1900141 localized to the plasma membrane of adipocytes , and the STEAP4 expression was *induced* by [TNF-alpha] in adipose tissue . Positive_regulation TNF STK10 10360689 619688 These data suggest that particle induced macrophage release of [TNF-alpha] and IL-6 does not require phagocytosis but is *dependent* on tyrosine and activity culminating in activation of Positive_regulation TNF STK10 10485710 644399 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Positive_regulation TNF STK11 10360689 619689 These data suggest that particle induced macrophage release of [TNF-alpha] and IL-6 does not require phagocytosis but is *dependent* on tyrosine and activity culminating in activation of Positive_regulation TNF STK11 10485710 644400 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Positive_regulation TNF STK16 10360689 619690 These data suggest that particle induced macrophage release of [TNF-alpha] and IL-6 does not require phagocytosis but is *dependent* on tyrosine and activity culminating in activation of Positive_regulation TNF STK16 10485710 644401 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Positive_regulation TNF STK19 10360689 619691 These data suggest that particle induced macrophage release of [TNF-alpha] and IL-6 does not require phagocytosis but is *dependent* on tyrosine and activity culminating in activation of Positive_regulation TNF STK19 10485710 644402 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Positive_regulation TNF STK24 10360689 619692 These data suggest that particle induced macrophage release of [TNF-alpha] and IL-6 does not require phagocytosis but is *dependent* on tyrosine and activity culminating in activation of Positive_regulation TNF STK24 10485710 644403 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Positive_regulation TNF STK25 10360689 619693 These data suggest that particle induced macrophage release of [TNF-alpha] and IL-6 does not require phagocytosis but is *dependent* on tyrosine and activity culminating in activation of Positive_regulation TNF STK25 10485710 644404 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Positive_regulation TNF STK3 10360689 619694 These data suggest that particle induced macrophage release of [TNF-alpha] and IL-6 does not require phagocytosis but is *dependent* on tyrosine and activity culminating in activation of Positive_regulation TNF STK3 10485710 644405 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Positive_regulation TNF STK31 10360689 619695 These data suggest that particle induced macrophage release of [TNF-alpha] and IL-6 does not require phagocytosis but is *dependent* on tyrosine and activity culminating in activation of Positive_regulation TNF STK31 10485710 644406 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Positive_regulation TNF STK33 10360689 619697 These data suggest that particle induced macrophage release of [TNF-alpha] and IL-6 does not require phagocytosis but is *dependent* on tyrosine and activity culminating in activation of Positive_regulation TNF STK33 10485710 644408 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Positive_regulation TNF STK35 10360689 619698 These data suggest that particle induced macrophage release of [TNF-alpha] and IL-6 does not require phagocytosis but is *dependent* on tyrosine and activity culminating in activation of Positive_regulation TNF STK35 10485710 644409 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Positive_regulation TNF STK36 10360689 619699 These data suggest that particle induced macrophage release of [TNF-alpha] and IL-6 does not require phagocytosis but is *dependent* on tyrosine and activity culminating in activation of Positive_regulation TNF STK36 10485710 644410 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Positive_regulation TNF STK38 10360689 619701 These data suggest that particle induced macrophage release of [TNF-alpha] and IL-6 does not require phagocytosis but is *dependent* on tyrosine and activity culminating in activation of Positive_regulation TNF STK38 10485710 644412 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Positive_regulation TNF STK39 10360689 619700 These data suggest that particle induced macrophage release of [TNF-alpha] and IL-6 does not require phagocytosis but is *dependent* on tyrosine and activity culminating in activation of Positive_regulation TNF STK39 10485710 644411 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Positive_regulation TNF STK4 10360689 619696 These data suggest that particle induced macrophage release of [TNF-alpha] and IL-6 does not require phagocytosis but is *dependent* on tyrosine and activity culminating in activation of Positive_regulation TNF STK4 10485710 644407 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Positive_regulation TNF STK4 18182160 1856527 Western blot analysis revealed that [TNF-alpha] *induced* activation of caspase 3 and in a time- and dose dependent manner . Positive_regulation TNF STK40 10360689 619702 These data suggest that particle induced macrophage release of [TNF-alpha] and IL-6 does not require phagocytosis but is *dependent* on tyrosine and activity culminating in activation of Positive_regulation TNF STK40 10485710 644413 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Positive_regulation TNF STS 16715133 1638307 We further show that whereas is not *required* for [TNFalpha] or TRAIL induced activation of NF-kappaB or caspase-8 , it can promote caspase-8 activation independently of death receptor-ligand interactions . Positive_regulation TNF STX1A 9657756 516858 We show here that purified *induces* [TNF] secretion by a human monocytic cell line , THP-1 , in a dose- and time dependent manner . Positive_regulation TNF STX1A 9657756 516859 Northern blot analyses show that *causes* increased [TNF-alpha] production through transcriptional activation . Positive_regulation TNF STX1A 9767525 538671 greatly *increased* [TNF] release and mRNA levels while CHX , at concentrations that produced similar inhibition of protein synthesis , had no effect on TNF production . Positive_regulation TNF STX2 11395932 823373 The results showed that anisodamine suppressed *induced* [TNF-alpha] production in a dose- and time dependent manner . Positive_regulation TNF STX2 11395932 823374 Anisodamine also suppressed *induced* [TNF-alpha] mRNA expression . Positive_regulation TNF STX2 11395932 823377 Taken together , our results indicate that anisodamine has an important regulatory effect on *induced* [TNF-alpha] production in vitro and in vivo . Positive_regulation TNF STX2 11675405 873219 It has been shown that *induces* [TNF-alpha] production and that activation of beta ( 2 ) -adrenoceptors downregulates TNF-alpha . Positive_regulation TNF STX2 11675405 873220 However , little is known about the signaling pathway by which beta(2)-adrenoceptor agonists suppress the *induced* [TNF-alpha] gene transcription . Positive_regulation TNF STX2 11675405 873221 ( 4 pg/ml ) stimulated MAPK ( p42/p44 , p38 ) and AP-1 and *increased* [TNF-alpha] promoter activity by 2.4-fold . Positive_regulation TNF STX2 11675405 873343 It is likely that cAMP-PKA and MAPK ( p42/p44 , p38 ) may play a critical role in the regulation of the *induced* [TNF-alpha] transcription via beta(2)-adrenoceptor activation . Positive_regulation TNF STX2 23043728 2726920 Our results demonstrate that the increased [TNF-a] and NO *induced* by were the predominant factors responsible for preterm delivery in rats . Positive_regulation TNF SUB1 11172611 784126 Similar to previous findings we observed that *initiated* a time dependent extracellular [TNF] accumulation . Positive_regulation TNF SUB1 11172611 784127 and b ) *induced* [TNF] production is a stress response that may not directly affect photocytotoxicity . Positive_regulation TNF SULT1E1 9643476 514462 We found that at low concentrations *enhanced* the production of both [TNF-alpha] and IL-1beta . Positive_regulation TNF SULT2A1 23347081 2764144 IL-33 induced hyperalgesia in naïve mice was reduced by treatments targeting TNF , CXCL1 , IL-1 , endothelin receptors and COX while carrageenin induced *dependent* [TNF-a] , CXCL1 , IL-1ß , IL-10 and PGE2 production and preproET-1 mRNA expression . Positive_regulation TNF SUMO2 23417988 2843322 In vitro , the expression of but not of SUMO-3 was *induced* by [TNF-a] . Positive_regulation TNF SUMO3 23417988 2843321 In vitro , the expression of SUMO-2 but not of was *induced* by [TNF-a] . Positive_regulation TNF SYK 19358895 2094460 Indeed , specific inhibition significantly *suppressed* the production of IL-12 , IL-6 , and [TNF-alpha] . Positive_regulation TNF SYK 19540939 2121314 It was an effective inducer of MAPKs- and *dependent* [TNF-alpha] and IL-6 secretion in murine resident peritoneal macrophages . Positive_regulation TNF SYK 22744837 2644411 It induced [TNF-a] and IL-6 production and the *activation* of and NF-?B signaling in resident peritoneal macrophages from ICR mice , which could be significantly inhibited by the blocking reagent laminarin . Positive_regulation TNF SYK 22744837 2644413 The [TNF-a] secretion and *activation* of signaling triggered by GFPBW1 were enhanced in RAW264.7 cells overexpressing wild but not mutant ( ?38 and Y15S ) Dectin-1 . Positive_regulation TNF SYNCRIP 11116146 786587 NF-kappaB activation by the [tumor necrosis factor receptor (TNFR)] *involves* the formation of a termed a signalosome . Positive_regulation TNF SYNM 11006354 735330 Taken together , these data show *induced* hepatic [TNFalpha] expression and suggest that TNFR-1 signaling may be up regulated following 4 and 7 daily DMN exposures . Positive_regulation TNF SYNM 17036385 1630979 treatment *induced* a highly up-regulated expression of [TNF-alpha] , TGF-beta , TIMP-1 , TIMP-2 , PDGF-beta , and MMP-2 . Positive_regulation TNF SYT1 10938077 737434 Previously , we have shown that [TNFalpha] *induces* phosphorylation at serine 529 and that this inducible phosphorylation increases NF-kappaB transcriptional activity on an exogenously supplied reporter ( ) . Positive_regulation TNF SYT1 12631113 1067644 The present data indicate that [TNF-alpha] *activation* of PKCzeta/iota , p42/44 MAPK , c-Jun/AP-1 , and are involved in TNF-alpha stimulated MC fractalkine expression , with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro . Positive_regulation TNF SYT1 15980040 1465288 Therefore , the goal of the present study was to examine the *role* of subunit phosphorylation in the regulation of [TNF-alpha] production in cultured neonatal ventricular myocytes . Positive_regulation TNF SYT1 16163708 1482645 In this study , we tested the hypothesis that phosphorylation of at 536 is *required* for [TNF-alpha] induced IkappaBalpha proteolysis that in turn controls p65 nuclear translocation . Positive_regulation TNF SYT1 17675290 1794071 By electrophoretic mobility shift assay analyses , [TNF-alpha] and lipopolysaccharide *induce* strong and p65/c-Rel heterodimer binding to both NF-kappaB and TF-kappaB probes . Positive_regulation TNF SYT1 20333651 2266146 We also showed that [TNF-alpha] *induced* Akt translocation and the formation of an complex . Positive_regulation TNF SYT1 8051093 267602 Both transactivation and [TNF-alpha] *induction* of the p53 promoter depended on an intact NF-kappa B site . Positive_regulation TNF SYT1 8746784 343500 We demonstrated here that [TNF-alpha] *induced* binding of NF kappa B p50 and to the NF kappa B-like element of the MHC class I promoter termed region I and IFN-gamma induced binding of IRF-1 to the adjacent interferon consensus sequence ( ICS ) . Positive_regulation TNF SYT11 23303671 2737910 *had* a direct effect on phagocytosis and on the secretion of [TNF] and IL-6 . Positive_regulation TNF TAB1 10187861 603058 Furthermore , [tumor necrosis factor-alpha] activated endogenous TAK1 , and the kinase negative *acted* as a dominant negative inhibitor against tumor necrosis factor-alpha induced NF-kappaB activation . Positive_regulation TNF TAB1 15590691 1368801 Immunoblotting with a novel phospho-TAK1 antibody revealed that [TNF-alpha] significantly *induced* the phosphorylation of endogenous at Thr-187 , and subsequently the phosphorylated forms of TAK1 rapidly disappeared . Positive_regulation TNF TAB1 16385569 1533416 Activation of endogenous , a mitogen activated protein kinase ( MAP3K ) regulating the JNK and p38 MAPK pathways , was *induced* rapidly by [TNF-alpha] , and co-transfection of TAK1 with its activator protein TAB1 stimulated activation of JNK and p38 MAPKs , which led to activation of the transcription factor AP-1 . Positive_regulation TNF TAB1 17052891 1683804 In this study , a critical *role* for in IL-1alpha or [TNFalpha] stimulated MAPK and NFkappaB activation was confirmed by inhibition of the nuclear accumulation of NFkappaB p65 and phosphorylated forms of c-Jun and p38 following siRNA mediated TAK1 silencing . Positive_regulation TNF TAB1 17348859 1733933 We also show that MDP activates ERK1 ( extracellular-signal regulated kinase 1 ) /ERK2 and p38alpha MAPK in human peripheral-blood mononuclear cells and that the activity of both MAPKs and are *required* for MDP induced signalling and production of IL-1beta and [TNFalpha] in these cells . Positive_regulation TNF TAB1 21335610 2443386 In general , crucially *regulates* IL-1 and [TNF] signalling in fibroblasts . Positive_regulation TNF TAB3 17384642 1727707 The formation of Smad7-TAB2 and complexes *resulted* in the suppression of [TNF] signaling through the adaptors TRAF2 , TAB2 and/or TAB3 , and TAK1 . Positive_regulation TNF TAC1 21904641 2478345 Whereas the and lactate levels did not change significantly , but CK and [TNF-a] *increased* significantly in the supplement group . Positive_regulation TNF TAC3 21904641 2478346 Whereas the and lactate levels did not change significantly , but CK and [TNF-a] *increased* significantly in the supplement group . Positive_regulation TNF TAC4 21904641 2478347 Whereas the and lactate levels did not change significantly , but CK and [TNF-a] *increased* significantly in the supplement group . Positive_regulation TNF TACR1 12649350 1070531 blockade clearly *inhibited* GalN/LPS induced production of [TNFalpha] and IFNgamma , whereas synthesis of the hepatoprotective cytokines IL-6 and IL-10 was increased . Positive_regulation TNF TANK 10201981 605775 We concluded that is partially *involved* in [TNF-alpha] mediated signaling through I kappa B/NF-kappa B in IEC . Positive_regulation TNF TANK 11098060 810195 The same fragment was capable of potently suppressing [TNF] receptor-1- and mediated nuclear factor-kappaB *activation* in reporter gene assays , providing a potential mechanism for the enhancement of TNF mediated apoptosis . Positive_regulation TNF TANK 15861135 1404149 [TNF-alpha] *induced* complex translocation to a Ubc6 containing compartment and TRAF2 ubiquitination . Positive_regulation TNF TANK 19810754 2159674 Our structural observation should prompt a re-evaluation of the *role* of in [TNFalpha] signaling and may indicate that TRAF2 associated proteins such as cIAPs may be the ubiquitin ligases for NF-kappaB signaling . Positive_regulation TNF TANK 20038584 2211144 In accord with the known inhibitory *role* of in the alternative NFkappaB pathway , TNFR2- , but not TNFR1-specific [TNF] induced depletion of cytosolic TRAF2 . Positive_regulation TNF TANK 21119000 2372295 Here we report that [TNF-a] and oxidative stress both *induce* phosphorylation at serines 11 and 55 and that this dual phosphorylation promotes the prolonged phase of IKK activation while inhibiting the prolonged phase of JNK activation . Positive_regulation TNF TANK 24378531 2911767 We find that in these cells [TNF] *induces* degradation , and this is blocked in TNFR2 ( -/- ) macrophages . Positive_regulation TNF TANK 7544915 318434 mediated *activation* of NF-kappa B by [TNF] receptor 2 and CD40 . Positive_regulation TNF TAP1 15240699 1270377 In macrophages from STAT-1 knockout mice , neither LPS nor [TNF-alpha] *induced* the expression of or Lmp2 . Positive_regulation TNF TAP2 22883599 2692272 *stimulated* [TNF-a] production in macrophages was significantly reduced in the presence of blocking antibodies for Dectin-1 and complement receptor 3 (CR3) , laminarin , or piceatannol ( a spleen tyrosine kinase inhibitor ) , suggesting that PS-F2 recognition by macrophages is mediated by Dectin-1 and CR3 receptors . Positive_regulation TNF TAPBP 11495157 846249 These data suggest that *increases* the expression of TNF-alpha mRNA in organ tissues and systemic [TNF-alpha] production , and reduces the survival rate of rats after thermal injury , but TEN does not . Positive_regulation TNF TAPBP 11688940 876050 The also *resulted* in significantly higher PLF and hepatic [TNF] levels , higher splenic IFN levels , and lower plasma IL-8 levels at 6 hours after challenge compared with the STD-TPN . Positive_regulation TNF TAPBP 1562785 184807 Therefore , long-term containing LCTs may *increase* [TNF] production , and this may be the result of an immunomodulating effect of fat . Positive_regulation TNF TAPBP 15652945 1364373 IEL cytokine mRNA expression was also significantly altered with : IL-2 and IL-10 expression declined , and IL-4 IL-6 , interferon gamma (IFN-gamma) , transforming growth factor beta-1 ( TGF-beta1 ) , and [tumor necrosis factor-alpha (TNF-alpha)] were *increased* , when compared with Control or TPN+Food mice . Positive_regulation TNF TAT 10843712 700214 HIV-1 protein is neurotoxic and *increases* macrophage and microglia production of [TNF-alpha] , a cytopathic cytokine linked to the neuropathogenesis of HIV dementia . Positive_regulation TNF TAT 10843712 700215 Accordingly , we tested the hypothesis that *induced* [TNF-alpha] production was dependent on the release of intracellular calcium from IP3 regulated calcium stores in primary macrophages . Positive_regulation TNF TAT 10843712 700216 Xestospongin C , BAPTA-AM , U73122 , and bisindolylmalemide significantly inhibited *induced* [TNF-alpha] production . Positive_regulation TNF TAT 10843712 700217 These results demonstrate that in macrophages , Tat induced release of calcium from IP3-sensitive intracellular stores and activation of nonconventional PKC isoforms play an important role in *induced* [TNF-alpha] production . Positive_regulation TNF TAT 1279199 202969 As TNF can increase the production of IL-1 and IL-6 and these inflammatory cytokines all enhance HIV-1 gene expression and affect the immune , vascular , and central nervous systems , the *activation* of [TNF] by may be part of a complex pathway in which HIV-1 uses viral products and host factors to increase its own expression and infectivity and to induce disease . Positive_regulation TNF TAT 14708348 1181044 [ HIV-1 *induces* [TNF-alpha] production by human monocytes : involvement of calcium and PKC pathways ] . Positive_regulation TNF TAT 15351206 1292550 Because activation of adenosine receptors decreases production of the pro-inflammatory cytokine TNF-alpha in several experimental paradigms both in vitro and in vivo , we hypothesized that adenosine receptor activation would control both increased intracellular calcium and [TNF-alpha] production *induced* by . Positive_regulation TNF TAT 15351206 1292551 *induced* [TNF-alpha] production was inhibited 90 +/- 6 % by CGS 21680 and concurrent treatment with okadaic acid blocked the inhibitory actions of CGS 21680 . Positive_regulation TNF TAT 15661163 1365055 Interestingly , we demonstrate that Tat induced calcium mobilization is tightly linked to TNF-alpha production , thus indicating that *induced* mobilization and [TNF-alpha] production are entirely mediated by DHP receptors , as shown by their total inhibition by nimodipine , calcicludine , or anti-alpha1D antisense oligonucleotides . Positive_regulation TNF TAT 16828290 1600181 The increase in [TNF-alpha] *induced* by + MA was not significantly different from that induced by Tat alone . Positive_regulation TNF TAT 18715150 2011853 Furthermore , inhibition of NADPH oxidase attenuated *induced* release of interleukin-6 (IL-6) , [tumor necrosis factor alpha (TNF)] , and monocyte chemoattractant protein 1 ( MCP-1 ) , and decreased microglial mediated neurotoxicity . Positive_regulation TNF TAT 19116667 2004742 Pretreatment with the NF-kappaB inhibitor parthenolide provided evidence that *induced* release of MCP-1 , IL-6 and [TNF-alpha] by astrocytes is NF-kappaB dependent . Positive_regulation TNF TAT 19287189 2046597 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via MAPK-NF-kappaB dependent mechanisms as well as *induced* [TNF-alpha] production in astrocytes . Positive_regulation TNF TAT 20686703 2299242 Nuclear factor-kappa B family member RelB inhibits human immunodeficiency virus-1 *induced* [tumor necrosis factor-alpha] production . Positive_regulation TNF TAT 20686703 2299244 Moreover , RelB overexpression in microglial cells inhibited *induced* [TNFalpha] synthesis in a manner that involved transcriptional repression of the TNFalpha promoter , and increased phosphorylation of RelA at serine 276 , a prerequisite for increased RelB/RelA protein interactions . Positive_regulation TNF TAT 20686703 2299249 Moreover , because *activates* both RelB and [TNFalpha] in microglia , and because Tat induces inflammatory TNFalpha synthesis via NF-kappaB , we posit that RelB serves as a cryoprotective , anti-inflammatory , counter-regulatory mechanism for pathogenic NF-kappaB activation . Positive_regulation TNF TAT 21419119 2432124 Additionally , the inhibition of *induced* production of MCP-1 and [TNF-a] via the inactivation of the ERK1/2 pathway may represent the anti-inflammatory mechanism of resveratrol in the hippocampus . Positive_regulation TNF TAT 21494611 2418116 Given the need for novel adjunctive therapies for HAND , we hypothesized that ibudilast would inhibit *induced* excess production of pro-inflammatory cytokines , such as [tumor necrosis factor-alpha] ( TNFa ) in microglial cells . Positive_regulation TNF TAT 8806505 382307 In HIV-1 infected cells can also *activate* the expression of [tumor necrosis factor (TNF)] . Positive_regulation TNF TAT 8806505 382311 Since TNF is increased in HIV-1 infected individuals and can activate HIV-1 gene expression or rescue Tat-defective HIV-1 proviruses , *activation* of [TNF] by may be part of a complex pathway in which HIV-1 uses its own expression to increase infectivity and to induce disease . Positive_regulation TNF TAT 9278385 451304 We examined the possibility that HIV protein , which is released extracellularly from infected cells , may *induce* the production of [TNF-alpha] . Positive_regulation TNF TAT 9278385 451305 In addition , *induced* [TNF-alpha] release was also linked to phospholipase C activation . Positive_regulation TNF TAT 9378998 465790 Therefore , the mechanism by which HIV-Tat activates monocyte function is dependent on *induced* production of cytokines ( IL-1 beta and [TNF-alpha] ) . Positive_regulation TNF TAT 9670843 519607 *Activation* of the TGFbeta-1 and [TNFalpha] promoters by wild-type was severely affected by the mutant peptides spanning residues 2 to 36 and 1 to 48 suggesting that both truncated Tat peptides may function as dominant negative mutants over TNFalpha and TGFbeta-1 gene transcription . Positive_regulation TNF TAT 9730685 530288 We review our data showing the *induction* of [TNF-alpha] by in primary human fetal astrocytes , human peripheral blood mononuclear cells , macrophages , and astrocytic and macrophage cell lines . Positive_regulation TNF TAT 9730685 530289 Nonetheless , these studies suggest that is an important *inducer* of [TNF-alpha] production and thus may play a key role in the pathogenesis of HIV related neurological disease . Positive_regulation TNF TBCA 12663680 1074596 QS21 and *induced* significant IFN-gamma , IL-4 and [tumor necrosis factor-alpha] expression , whereas alum induced primarily IL-4 production . Positive_regulation TNF TBCA 17387690 1727724 Intrathecal administration of NC attenuated the *induced* increases of calcitonin gene related peptide , transient receptor potential vanilloid-1 , and [tumor necrosis factor-alpha] in DRG neurons . Positive_regulation TNF TBCA 18721668 1955880 ( 3 ) Repeated EA stimulation of ipsilateral ` Huan-Tiao ' ( GB30 ) and ` Yang-Ling-Quan ' ( GB34 ) acupoints significantly suppressed CFA induced hyperalgesia , and markedly inhibited the *induced* increase of the level of PGE ( 2 ) as well as IL-1beta , IL-6 , and [TNF-alpha] in the spinal cord ; Positive_regulation TNF TBCA 7575997 333220 In previous studies we reported that a single injection of complete Freund's adjuvant (CFA) in early life inhibits the development of autoimmune diabetes in BB diabetes-prone ( DP ) rats , and that *upregulates* [tumor necrosis factor-alpha (TNF alpha)] production by macrophages of DP rats . Positive_regulation TNF TCEA1 16307187 1486478 Gradual nerve by limb lengthening *induces* production of [TNFalpha] in Schwann cells . Positive_regulation TNF TCF12 10200294 605475 A novel lipopolysaccharide induced *regulating* [tumor necrosis factor] alpha gene expression : molecular cloning , sequencing , characterization , and chromosomal assignment . Positive_regulation TNF TCF12 10792947 689503 Serum [tumor necrosis factor (TNF)] protein ( ELISA ) , hepatic TNF mRNA ( reverse transcription polymerase chain reaction ) , and hepatic *activation* of the nuclear factor kappa B ( electrophoretic mobility shift assay ) were also determined . Positive_regulation TNF TCF12 12091427 960132 Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB , whereas [TNF-alpha] potently *induced* this . Positive_regulation TNF TCF12 12161100 971821 Expression of [TNF-alpha] and IL-6 was *regulated* by a , nuclear factor (NF)-kappaB . Positive_regulation TNF TCF12 12890427 1117247 At the molecular level , EXPLY-37 did not inhibit the *activation* of the nuclear factor kappa B (NF-kappaB) by [TNF] . Positive_regulation TNF TCF12 14646597 1173184 [TNF-alpha] *induced* activation of both c-jun NH ( 2 ) -terminal kinase ( JNK ) and nuclear ( NF-kappaB ) in 3T3-L1 cells . Positive_regulation TNF TCF12 16006484 1459250 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of [TNF-alpha] , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TNF TCF12 16046706 1438308 Palmitate activates the NF-kappaB and *induces* IL-6 and [TNFalpha] expression in 3T3-L1 adipocytes . Positive_regulation TNF TCF12 17035338 1674534 Taken together , our data suggest that the [TNF-alpha] produced in response to IFN-gamma is *required* for iNOS induction by activating NF-kappaB . Positive_regulation TNF TCF12 18554501 1929364 Lipopolysaccharide induced TNF-alpha factor ( LITAF ) , a , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Positive_regulation TNF TCF12 1906501 161734 An NF-kappa B-like *mediates* [IL-1/TNF-alpha] induction of gro in human fibroblasts . Positive_regulation TNF TCF12 19479048 2085726 [TNFalpha] signaling is *mediated* by the , Nuclear Factor (NF)-kappaB , which regulates genes controlling several physiological processes including the innate immune responses , cell death , and inflammation . Positive_regulation TNF TCF12 19487969 2185523 In addition , lung injury in the Ron TK-deficient ( TK ( -/- ) ) mice was associated with increased activation of the , nuclear factor-kappaB (NF-kappaB) , and significantly *increased* intrapulmonary expression of [TNFalpha] . Positive_regulation TNF TCF12 21389273 2443508 Functionally , TNF-a stimulated H ( 2 ) O ( 2 ) production was also blocked by MCD and DES ( 194.6 ± 15.4 % vs. 90.6 ± 15.9 % and 148.8 ± 20.4 % ) , and the *activation* of the pivotal proinflammatory , NF-?B , by [TNF-a] was reversed by MCD and DES as well as by small interfering RNAs of Duox1 or ASMase . Positive_regulation TNF TCF12 24223737 2865187 Furthermore , rJHP0290 induced [TNF] release was partly *dependent* on activation of nuclear ( NF-?B ) . Positive_regulation TNF TCF12 8725122 373824 The adenoviral , E1A 13S , *trans-activates* the human [tumor necrosis factor-alpha] promoter . Positive_regulation TNF TCF12 8798568 381642 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by interleukin-1beta plus [tumor necrosis factor-alpha] , and its full induction *requires* the presence of the , c-FOS . Positive_regulation TNF TCF12 9792645 542586 [Tumor necrosis factor-alpha] *activation* of nuclear in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha . Positive_regulation TNF TCF12 9852224 554663 Altered binding of the NF-GMa is *involved* in the upregulated production of [TNF-alpha] by macrophages of mammary tumor bearing mice . Positive_regulation TNF TCF15 10200294 605476 A novel lipopolysaccharide induced *regulating* [tumor necrosis factor] alpha gene expression : molecular cloning , sequencing , characterization , and chromosomal assignment . Positive_regulation TNF TCF15 10792947 689504 Serum tumor necrosis factor (TNF) protein ( ELISA ) , hepatic [TNF] mRNA ( reverse transcription polymerase chain reaction ) , and hepatic *activation* of the nuclear factor kappa B ( electrophoretic mobility shift assay ) were also determined . Positive_regulation TNF TCF15 12091427 960133 Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB , whereas [TNF-alpha] potently *induced* this . Positive_regulation TNF TCF15 12161100 971822 Expression of [TNF-alpha] and IL-6 was *regulated* by a , nuclear factor (NF)-kappaB . Positive_regulation TNF TCF15 12890427 1117248 At the molecular level , EXPLY-37 did not inhibit the *activation* of the nuclear factor kappa B (NF-kappaB) by [TNF] . Positive_regulation TNF TCF15 14646597 1173185 [TNF-alpha] *induced* activation of both c-jun NH ( 2 ) -terminal kinase ( JNK ) and nuclear ( NF-kappaB ) in 3T3-L1 cells . Positive_regulation TNF TCF15 16006484 1459251 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of [TNF-alpha] , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TNF TCF15 16046706 1438309 Palmitate activates the NF-kappaB and *induces* IL-6 and [TNFalpha] expression in 3T3-L1 adipocytes . Positive_regulation TNF TCF15 17035338 1674535 Taken together , our data suggest that the [TNF-alpha] produced in response to IFN-gamma is *required* for iNOS induction by activating NF-kappaB . Positive_regulation TNF TCF15 18554501 1929365 Lipopolysaccharide induced TNF-alpha factor ( LITAF ) , a , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Positive_regulation TNF TCF15 1906501 161735 An NF-kappa B-like *mediates* [IL-1/TNF-alpha] induction of gro in human fibroblasts . Positive_regulation TNF TCF15 19479048 2085727 [TNFalpha] signaling is *mediated* by the , Nuclear Factor (NF)-kappaB , which regulates genes controlling several physiological processes including the innate immune responses , cell death , and inflammation . Positive_regulation TNF TCF15 19487969 2185524 In addition , lung injury in the Ron TK-deficient ( TK ( -/- ) ) mice was associated with increased activation of the , nuclear factor-kappaB (NF-kappaB) , and significantly *increased* intrapulmonary expression of [TNFalpha] . Positive_regulation TNF TCF15 21389273 2443509 Functionally , TNF-a stimulated H ( 2 ) O ( 2 ) production was also blocked by MCD and DES ( 194.6 ± 15.4 % vs. 90.6 ± 15.9 % and 148.8 ± 20.4 % ) , and the *activation* of the pivotal proinflammatory , NF-?B , by [TNF-a] was reversed by MCD and DES as well as by small interfering RNAs of Duox1 or ASMase . Positive_regulation TNF TCF15 24223737 2865188 Furthermore , rJHP0290 induced [TNF] release was partly *dependent* on activation of nuclear ( NF-?B ) . Positive_regulation TNF TCF15 8725122 373825 The adenoviral , E1A 13S , *trans-activates* the human [tumor necrosis factor-alpha] promoter . Positive_regulation TNF TCF15 8798568 381643 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by interleukin-1beta plus [tumor necrosis factor-alpha] , and its full induction *requires* the presence of the , c-FOS . Positive_regulation TNF TCF15 9792645 542587 [Tumor necrosis factor-alpha] *activation* of nuclear in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha . Positive_regulation TNF TCF15 9852224 554664 Altered binding of the NF-GMa is *involved* in the upregulated production of [TNF-alpha] by macrophages of mammary tumor bearing mice . Positive_regulation TNF TCF19 10200294 605477 A novel lipopolysaccharide induced *regulating* [tumor necrosis factor] alpha gene expression : molecular cloning , sequencing , characterization , and chromosomal assignment . Positive_regulation TNF TCF19 10792947 689505 Serum [tumor necrosis factor (TNF)] protein ( ELISA ) , hepatic TNF mRNA ( reverse transcription polymerase chain reaction ) , and hepatic *activation* of the nuclear factor kappa B ( electrophoretic mobility shift assay ) were also determined . Positive_regulation TNF TCF19 12091427 960134 Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB , whereas [TNF-alpha] potently *induced* this . Positive_regulation TNF TCF19 12161100 971823 Expression of [TNF-alpha] and IL-6 was *regulated* by a , nuclear factor (NF)-kappaB . Positive_regulation TNF TCF19 12890427 1117249 At the molecular level , EXPLY-37 did not inhibit the *activation* of the nuclear factor kappa B (NF-kappaB) by [TNF] . Positive_regulation TNF TCF19 14646597 1173186 [TNF-alpha] *induced* activation of both c-jun NH ( 2 ) -terminal kinase ( JNK ) and nuclear ( NF-kappaB ) in 3T3-L1 cells . Positive_regulation TNF TCF19 16006484 1459252 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of [TNF-alpha] , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TNF TCF19 16046706 1438310 Palmitate activates the NF-kappaB and *induces* IL-6 and [TNFalpha] expression in 3T3-L1 adipocytes . Positive_regulation TNF TCF19 17035338 1674536 Taken together , our data suggest that the [TNF-alpha] produced in response to IFN-gamma is *required* for iNOS induction by activating NF-kappaB . Positive_regulation TNF TCF19 18554501 1929366 Lipopolysaccharide induced TNF-alpha factor ( LITAF ) , a , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Positive_regulation TNF TCF19 1906501 161736 An NF-kappa B-like *mediates* [IL-1/TNF-alpha] induction of gro in human fibroblasts . Positive_regulation TNF TCF19 19479048 2085728 [TNFalpha] signaling is *mediated* by the , Nuclear Factor (NF)-kappaB , which regulates genes controlling several physiological processes including the innate immune responses , cell death , and inflammation . Positive_regulation TNF TCF19 19487969 2185525 In addition , lung injury in the Ron TK-deficient ( TK ( -/- ) ) mice was associated with increased activation of the , nuclear factor-kappaB (NF-kappaB) , and significantly *increased* intrapulmonary expression of [TNFalpha] . Positive_regulation TNF TCF19 21389273 2443510 Functionally , TNF-a stimulated H ( 2 ) O ( 2 ) production was also blocked by MCD and DES ( 194.6 ± 15.4 % vs. 90.6 ± 15.9 % and 148.8 ± 20.4 % ) , and the *activation* of the pivotal proinflammatory , NF-?B , by [TNF-a] was reversed by MCD and DES as well as by small interfering RNAs of Duox1 or ASMase . Positive_regulation TNF TCF19 24223737 2865189 Furthermore , rJHP0290 induced [TNF] release was partly *dependent* on activation of nuclear ( NF-?B ) . Positive_regulation TNF TCF19 8725122 373826 The adenoviral , E1A 13S , *trans-activates* the human [tumor necrosis factor-alpha] promoter . Positive_regulation TNF TCF19 8798568 381644 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by interleukin-1beta plus [tumor necrosis factor-alpha] , and its full induction *requires* the presence of the , c-FOS . Positive_regulation TNF TCF19 9792645 542588 [Tumor necrosis factor-alpha] *activation* of nuclear in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha . Positive_regulation TNF TCF19 9852224 554665 Altered binding of the NF-GMa is *involved* in the upregulated production of [TNF-alpha] by macrophages of mammary tumor bearing mice . Positive_regulation TNF TCF20 10200294 605478 A novel lipopolysaccharide induced *regulating* [tumor necrosis factor] alpha gene expression : molecular cloning , sequencing , characterization , and chromosomal assignment . Positive_regulation TNF TCF20 10792947 689506 Serum tumor necrosis factor (TNF) protein ( ELISA ) , hepatic [TNF] mRNA ( reverse transcription polymerase chain reaction ) , and hepatic *activation* of the nuclear factor kappa B ( electrophoretic mobility shift assay ) were also determined . Positive_regulation TNF TCF20 12091427 960135 Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB , whereas [TNF-alpha] potently *induced* this . Positive_regulation TNF TCF20 12161100 971824 Expression of [TNF-alpha] and IL-6 was *regulated* by a , nuclear factor (NF)-kappaB . Positive_regulation TNF TCF20 12890427 1117250 At the molecular level , EXPLY-37 did not inhibit the *activation* of the nuclear factor kappa B (NF-kappaB) by [TNF] . Positive_regulation TNF TCF20 14646597 1173187 [TNF-alpha] *induced* activation of both c-jun NH ( 2 ) -terminal kinase ( JNK ) and nuclear ( NF-kappaB ) in 3T3-L1 cells . Positive_regulation TNF TCF20 16006484 1459253 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of [TNF-alpha] , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TNF TCF20 16046706 1438311 Palmitate activates the NF-kappaB and *induces* IL-6 and [TNFalpha] expression in 3T3-L1 adipocytes . Positive_regulation TNF TCF20 17035338 1674537 Taken together , our data suggest that the [TNF-alpha] produced in response to IFN-gamma is *required* for iNOS induction by activating NF-kappaB . Positive_regulation TNF TCF20 18554501 1929367 Lipopolysaccharide induced TNF-alpha factor ( LITAF ) , a , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Positive_regulation TNF TCF20 1906501 161737 An NF-kappa B-like *mediates* [IL-1/TNF-alpha] induction of gro in human fibroblasts . Positive_regulation TNF TCF20 19479048 2085729 [TNFalpha] signaling is *mediated* by the , Nuclear Factor (NF)-kappaB , which regulates genes controlling several physiological processes including the innate immune responses , cell death , and inflammation . Positive_regulation TNF TCF20 19487969 2185526 In addition , lung injury in the Ron TK-deficient ( TK ( -/- ) ) mice was associated with increased activation of the , nuclear factor-kappaB (NF-kappaB) , and significantly *increased* intrapulmonary expression of [TNFalpha] . Positive_regulation TNF TCF20 21389273 2443511 Functionally , TNF-a stimulated H ( 2 ) O ( 2 ) production was also blocked by MCD and DES ( 194.6 ± 15.4 % vs. 90.6 ± 15.9 % and 148.8 ± 20.4 % ) , and the *activation* of the pivotal proinflammatory , NF-?B , by [TNF-a] was reversed by MCD and DES as well as by small interfering RNAs of Duox1 or ASMase . Positive_regulation TNF TCF20 24223737 2865190 Furthermore , rJHP0290 induced [TNF] release was partly *dependent* on activation of nuclear ( NF-?B ) . Positive_regulation TNF TCF20 8725122 373827 The adenoviral , E1A 13S , *trans-activates* the human [tumor necrosis factor-alpha] promoter . Positive_regulation TNF TCF20 8798568 381645 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by interleukin-1beta plus [tumor necrosis factor-alpha] , and its full induction *requires* the presence of the , c-FOS . Positive_regulation TNF TCF20 9792645 542589 [Tumor necrosis factor-alpha] *activation* of nuclear in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha . Positive_regulation TNF TCF20 9852224 554666 Altered binding of the NF-GMa is *involved* in the upregulated production of [TNF-alpha] by macrophages of mammary tumor bearing mice . Positive_regulation TNF TCF21 10200294 605479 A novel lipopolysaccharide induced *regulating* [tumor necrosis factor] alpha gene expression : molecular cloning , sequencing , characterization , and chromosomal assignment . Positive_regulation TNF TCF21 10792947 689507 Serum [tumor necrosis factor (TNF)] protein ( ELISA ) , hepatic TNF mRNA ( reverse transcription polymerase chain reaction ) , and hepatic *activation* of the nuclear factor kappa B ( electrophoretic mobility shift assay ) were also determined . Positive_regulation TNF TCF21 12091427 960136 Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB , whereas [TNF-alpha] potently *induced* this . Positive_regulation TNF TCF21 12161100 971825 Expression of [TNF-alpha] and IL-6 was *regulated* by a , nuclear factor (NF)-kappaB . Positive_regulation TNF TCF21 12890427 1117251 At the molecular level , EXPLY-37 did not inhibit the *activation* of the nuclear factor kappa B (NF-kappaB) by [TNF] . Positive_regulation TNF TCF21 14646597 1173188 [TNF-alpha] *induced* activation of both c-jun NH ( 2 ) -terminal kinase ( JNK ) and nuclear ( NF-kappaB ) in 3T3-L1 cells . Positive_regulation TNF TCF21 16006484 1459254 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of [TNF-alpha] , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TNF TCF21 16046706 1438312 Palmitate activates the NF-kappaB and *induces* IL-6 and [TNFalpha] expression in 3T3-L1 adipocytes . Positive_regulation TNF TCF21 17035338 1674538 Taken together , our data suggest that the [TNF-alpha] produced in response to IFN-gamma is *required* for iNOS induction by activating NF-kappaB . Positive_regulation TNF TCF21 18554501 1929368 Lipopolysaccharide induced TNF-alpha factor ( LITAF ) , a , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Positive_regulation TNF TCF21 1906501 161738 An NF-kappa B-like *mediates* [IL-1/TNF-alpha] induction of gro in human fibroblasts . Positive_regulation TNF TCF21 19479048 2085730 [TNFalpha] signaling is *mediated* by the , Nuclear Factor (NF)-kappaB , which regulates genes controlling several physiological processes including the innate immune responses , cell death , and inflammation . Positive_regulation TNF TCF21 19487969 2185527 In addition , lung injury in the Ron TK-deficient ( TK ( -/- ) ) mice was associated with increased activation of the , nuclear factor-kappaB (NF-kappaB) , and significantly *increased* intrapulmonary expression of [TNFalpha] . Positive_regulation TNF TCF21 21389273 2443512 Functionally , TNF-a stimulated H ( 2 ) O ( 2 ) production was also blocked by MCD and DES ( 194.6 ± 15.4 % vs. 90.6 ± 15.9 % and 148.8 ± 20.4 % ) , and the *activation* of the pivotal proinflammatory , NF-?B , by [TNF-a] was reversed by MCD and DES as well as by small interfering RNAs of Duox1 or ASMase . Positive_regulation TNF TCF21 24223737 2865191 Furthermore , rJHP0290 induced [TNF] release was partly *dependent* on activation of nuclear ( NF-?B ) . Positive_regulation TNF TCF21 8725122 373828 The adenoviral , E1A 13S , *trans-activates* the human [tumor necrosis factor-alpha] promoter . Positive_regulation TNF TCF21 8798568 381646 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by interleukin-1beta plus [tumor necrosis factor-alpha] , and its full induction *requires* the presence of the , c-FOS . Positive_regulation TNF TCF21 9792645 542590 [Tumor necrosis factor-alpha] *activation* of nuclear in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha . Positive_regulation TNF TCF21 9852224 554667 Altered binding of the NF-GMa is *involved* in the upregulated production of [TNF-alpha] by macrophages of mammary tumor bearing mice . Positive_regulation TNF TCF23 10200294 605483 A novel lipopolysaccharide induced *regulating* [tumor necrosis factor] alpha gene expression : molecular cloning , sequencing , characterization , and chromosomal assignment . Positive_regulation TNF TCF23 10792947 689511 Serum [tumor necrosis factor (TNF)] protein ( ELISA ) , hepatic TNF mRNA ( reverse transcription polymerase chain reaction ) , and hepatic *activation* of the nuclear factor kappa B ( electrophoretic mobility shift assay ) were also determined . Positive_regulation TNF TCF23 12091427 960140 Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB , whereas [TNF-alpha] potently *induced* this . Positive_regulation TNF TCF23 12161100 971829 Expression of [TNF-alpha] and IL-6 was *regulated* by a , nuclear factor (NF)-kappaB . Positive_regulation TNF TCF23 12890427 1117255 At the molecular level , EXPLY-37 did not inhibit the *activation* of the nuclear factor kappa B (NF-kappaB) by [TNF] . Positive_regulation TNF TCF23 14646597 1173192 [TNF-alpha] *induced* activation of both c-jun NH ( 2 ) -terminal kinase ( JNK ) and nuclear ( NF-kappaB ) in 3T3-L1 cells . Positive_regulation TNF TCF23 16006484 1459258 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of [TNF-alpha] , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TNF TCF23 16046706 1438316 Palmitate activates the NF-kappaB and *induces* IL-6 and [TNFalpha] expression in 3T3-L1 adipocytes . Positive_regulation TNF TCF23 17035338 1674542 Taken together , our data suggest that the [TNF-alpha] produced in response to IFN-gamma is *required* for iNOS induction by activating NF-kappaB . Positive_regulation TNF TCF23 18554501 1929373 Lipopolysaccharide induced TNF-alpha factor ( LITAF ) , a , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Positive_regulation TNF TCF23 1906501 161742 An NF-kappa B-like *mediates* [IL-1/TNF-alpha] induction of gro in human fibroblasts . Positive_regulation TNF TCF23 19479048 2085734 [TNFalpha] signaling is *mediated* by the , Nuclear Factor (NF)-kappaB , which regulates genes controlling several physiological processes including the innate immune responses , cell death , and inflammation . Positive_regulation TNF TCF23 19487969 2185531 In addition , lung injury in the Ron TK-deficient ( TK ( -/- ) ) mice was associated with increased activation of the , nuclear factor-kappaB (NF-kappaB) , and significantly *increased* intrapulmonary expression of [TNFalpha] . Positive_regulation TNF TCF23 21389273 2443516 Functionally , TNF-a stimulated H ( 2 ) O ( 2 ) production was also blocked by MCD and DES ( 194.6 ± 15.4 % vs. 90.6 ± 15.9 % and 148.8 ± 20.4 % ) , and the *activation* of the pivotal proinflammatory , NF-?B , by [TNF-a] was reversed by MCD and DES as well as by small interfering RNAs of Duox1 or ASMase . Positive_regulation TNF TCF23 24223737 2865195 Furthermore , rJHP0290 induced [TNF] release was partly *dependent* on activation of nuclear ( NF-?B ) . Positive_regulation TNF TCF23 8725122 373832 The adenoviral , E1A 13S , *trans-activates* the human [tumor necrosis factor-alpha] promoter . Positive_regulation TNF TCF23 8798568 381650 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by interleukin-1beta plus [tumor necrosis factor-alpha] , and its full induction *requires* the presence of the , c-FOS . Positive_regulation TNF TCF23 9792645 542594 [Tumor necrosis factor-alpha] *activation* of nuclear in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha . Positive_regulation TNF TCF23 9852224 554671 Altered binding of the NF-GMa is *involved* in the upregulated production of [TNF-alpha] by macrophages of mammary tumor bearing mice . Positive_regulation TNF TCF24 10200294 605485 A novel lipopolysaccharide induced *regulating* [tumor necrosis factor] alpha gene expression : molecular cloning , sequencing , characterization , and chromosomal assignment . Positive_regulation TNF TCF24 10792947 689513 Serum [tumor necrosis factor (TNF)] protein ( ELISA ) , hepatic TNF mRNA ( reverse transcription polymerase chain reaction ) , and hepatic *activation* of the nuclear factor kappa B ( electrophoretic mobility shift assay ) were also determined . Positive_regulation TNF TCF24 12091427 960142 Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB , whereas [TNF-alpha] potently *induced* this . Positive_regulation TNF TCF24 12161100 971831 Expression of [TNF-alpha] and IL-6 was *regulated* by a , nuclear factor (NF)-kappaB . Positive_regulation TNF TCF24 12890427 1117257 At the molecular level , EXPLY-37 did not inhibit the *activation* of the nuclear factor kappa B (NF-kappaB) by [TNF] . Positive_regulation TNF TCF24 14646597 1173194 [TNF-alpha] *induced* activation of both c-jun NH ( 2 ) -terminal kinase ( JNK ) and nuclear ( NF-kappaB ) in 3T3-L1 cells . Positive_regulation TNF TCF24 16006484 1459260 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of [TNF-alpha] , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TNF TCF24 16046706 1438318 Palmitate activates the NF-kappaB and *induces* IL-6 and [TNFalpha] expression in 3T3-L1 adipocytes . Positive_regulation TNF TCF24 17035338 1674544 Taken together , our data suggest that the [TNF-alpha] produced in response to IFN-gamma is *required* for iNOS induction by activating NF-kappaB . Positive_regulation TNF TCF24 18554501 1929375 Lipopolysaccharide induced TNF-alpha factor ( LITAF ) , a , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Positive_regulation TNF TCF24 1906501 161744 An NF-kappa B-like *mediates* [IL-1/TNF-alpha] induction of gro in human fibroblasts . Positive_regulation TNF TCF24 19479048 2085736 [TNFalpha] signaling is *mediated* by the , Nuclear Factor (NF)-kappaB , which regulates genes controlling several physiological processes including the innate immune responses , cell death , and inflammation . Positive_regulation TNF TCF24 19487969 2185533 In addition , lung injury in the Ron TK-deficient ( TK ( -/- ) ) mice was associated with increased activation of the , nuclear factor-kappaB (NF-kappaB) , and significantly *increased* intrapulmonary expression of [TNFalpha] . Positive_regulation TNF TCF24 21389273 2443518 Functionally , TNF-a stimulated H ( 2 ) O ( 2 ) production was also blocked by MCD and DES ( 194.6 ± 15.4 % vs. 90.6 ± 15.9 % and 148.8 ± 20.4 % ) , and the *activation* of the pivotal proinflammatory , NF-?B , by [TNF-a] was reversed by MCD and DES as well as by small interfering RNAs of Duox1 or ASMase . Positive_regulation TNF TCF24 24223737 2865197 Furthermore , rJHP0290 induced [TNF] release was partly *dependent* on activation of nuclear ( NF-?B ) . Positive_regulation TNF TCF24 8725122 373834 The adenoviral , E1A 13S , *trans-activates* the human [tumor necrosis factor-alpha] promoter . Positive_regulation TNF TCF24 8798568 381652 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by interleukin-1beta plus [tumor necrosis factor-alpha] , and its full induction *requires* the presence of the , c-FOS . Positive_regulation TNF TCF24 9792645 542596 [Tumor necrosis factor-alpha] *activation* of nuclear in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha . Positive_regulation TNF TCF24 9852224 554673 Altered binding of the NF-GMa is *involved* in the upregulated production of [TNF-alpha] by macrophages of mammary tumor bearing mice . Positive_regulation TNF TCF25 10200294 605484 A novel lipopolysaccharide induced *regulating* [tumor necrosis factor] alpha gene expression : molecular cloning , sequencing , characterization , and chromosomal assignment . Positive_regulation TNF TCF25 10792947 689512 Serum tumor necrosis factor (TNF) protein ( ELISA ) , hepatic [TNF] mRNA ( reverse transcription polymerase chain reaction ) , and hepatic *activation* of the nuclear factor kappa B ( electrophoretic mobility shift assay ) were also determined . Positive_regulation TNF TCF25 12091427 960141 Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB , whereas [TNF-alpha] potently *induced* this . Positive_regulation TNF TCF25 12161100 971830 Expression of [TNF-alpha] and IL-6 was *regulated* by a , nuclear factor (NF)-kappaB . Positive_regulation TNF TCF25 12890427 1117256 At the molecular level , EXPLY-37 did not inhibit the *activation* of the nuclear factor kappa B (NF-kappaB) by [TNF] . Positive_regulation TNF TCF25 14646597 1173193 [TNF-alpha] *induced* activation of both c-jun NH ( 2 ) -terminal kinase ( JNK ) and nuclear ( NF-kappaB ) in 3T3-L1 cells . Positive_regulation TNF TCF25 16006484 1459259 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of [TNF-alpha] , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TNF TCF25 16046706 1438317 Palmitate activates the NF-kappaB and *induces* IL-6 and [TNFalpha] expression in 3T3-L1 adipocytes . Positive_regulation TNF TCF25 17035338 1674543 Taken together , our data suggest that the [TNF-alpha] produced in response to IFN-gamma is *required* for iNOS induction by activating NF-kappaB . Positive_regulation TNF TCF25 18554501 1929374 Lipopolysaccharide induced TNF-alpha factor ( LITAF ) , a , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Positive_regulation TNF TCF25 1906501 161743 An NF-kappa B-like *mediates* [IL-1/TNF-alpha] induction of gro in human fibroblasts . Positive_regulation TNF TCF25 19479048 2085735 [TNFalpha] signaling is *mediated* by the , Nuclear Factor (NF)-kappaB , which regulates genes controlling several physiological processes including the innate immune responses , cell death , and inflammation . Positive_regulation TNF TCF25 19487969 2185532 In addition , lung injury in the Ron TK-deficient ( TK ( -/- ) ) mice was associated with increased activation of the , nuclear factor-kappaB (NF-kappaB) , and significantly *increased* intrapulmonary expression of [TNFalpha] . Positive_regulation TNF TCF25 21389273 2443517 Functionally , TNF-a stimulated H ( 2 ) O ( 2 ) production was also blocked by MCD and DES ( 194.6 ± 15.4 % vs. 90.6 ± 15.9 % and 148.8 ± 20.4 % ) , and the *activation* of the pivotal proinflammatory , NF-?B , by [TNF-a] was reversed by MCD and DES as well as by small interfering RNAs of Duox1 or ASMase . Positive_regulation TNF TCF25 24223737 2865196 Furthermore , rJHP0290 induced [TNF] release was partly *dependent* on activation of nuclear ( NF-?B ) . Positive_regulation TNF TCF25 8725122 373833 The adenoviral , E1A 13S , *trans-activates* the human [tumor necrosis factor-alpha] promoter . Positive_regulation TNF TCF25 8798568 381651 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by interleukin-1beta plus [tumor necrosis factor-alpha] , and its full induction *requires* the presence of the , c-FOS . Positive_regulation TNF TCF25 9792645 542595 [Tumor necrosis factor-alpha] *activation* of nuclear in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha . Positive_regulation TNF TCF25 9852224 554672 Altered binding of the NF-GMa is *involved* in the upregulated production of [TNF-alpha] by macrophages of mammary tumor bearing mice . Positive_regulation TNF TCF3 10200294 605480 A novel lipopolysaccharide induced *regulating* [tumor necrosis factor] alpha gene expression : molecular cloning , sequencing , characterization , and chromosomal assignment . Positive_regulation TNF TCF3 10792947 689508 Serum tumor necrosis factor (TNF) protein ( ELISA ) , hepatic [TNF] mRNA ( reverse transcription polymerase chain reaction ) , and hepatic *activation* of the nuclear factor kappa B ( electrophoretic mobility shift assay ) were also determined . Positive_regulation TNF TCF3 12091427 960137 Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB , whereas [TNF-alpha] potently *induced* this . Positive_regulation TNF TCF3 12161100 971826 Expression of [TNF-alpha] and IL-6 was *regulated* by a , nuclear factor (NF)-kappaB . Positive_regulation TNF TCF3 12890427 1117252 At the molecular level , EXPLY-37 did not inhibit the *activation* of the nuclear factor kappa B (NF-kappaB) by [TNF] . Positive_regulation TNF TCF3 12972287 1139469 Interestingly , the TF was shown to be specifically *activated* by [TNFalpha] but was not affected by treatment with PMA . Positive_regulation TNF TCF3 14646597 1173189 [TNF-alpha] *induced* activation of both c-jun NH ( 2 ) -terminal kinase ( JNK ) and nuclear ( NF-kappaB ) in 3T3-L1 cells . Positive_regulation TNF TCF3 16006484 1459255 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of [TNF-alpha] , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TNF TCF3 16046706 1438313 Palmitate activates the NF-kappaB and *induces* IL-6 and [TNFalpha] expression in 3T3-L1 adipocytes . Positive_regulation TNF TCF3 17035338 1674539 Taken together , our data suggest that the [TNF-alpha] produced in response to IFN-gamma is *required* for iNOS induction by activating NF-kappaB . Positive_regulation TNF TCF3 18554501 1929369 Lipopolysaccharide induced TNF-alpha factor ( LITAF ) , a , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Positive_regulation TNF TCF3 1906501 161739 An NF-kappa B-like *mediates* [IL-1/TNF-alpha] induction of gro in human fibroblasts . Positive_regulation TNF TCF3 19479048 2085731 [TNFalpha] signaling is *mediated* by the , Nuclear Factor (NF)-kappaB , which regulates genes controlling several physiological processes including the innate immune responses , cell death , and inflammation . Positive_regulation TNF TCF3 19487969 2185528 In addition , lung injury in the Ron TK-deficient ( TK ( -/- ) ) mice was associated with increased activation of the , nuclear factor-kappaB (NF-kappaB) , and significantly *increased* intrapulmonary expression of [TNFalpha] . Positive_regulation TNF TCF3 21389273 2443513 Functionally , TNF-a stimulated H ( 2 ) O ( 2 ) production was also blocked by MCD and DES ( 194.6 ± 15.4 % vs. 90.6 ± 15.9 % and 148.8 ± 20.4 % ) , and the *activation* of the pivotal proinflammatory , NF-?B , by [TNF-a] was reversed by MCD and DES as well as by small interfering RNAs of Duox1 or ASMase . Positive_regulation TNF TCF3 24223737 2865192 Furthermore , rJHP0290 induced [TNF] release was partly *dependent* on activation of nuclear ( NF-?B ) . Positive_regulation TNF TCF3 8725122 373829 The adenoviral , E1A 13S , *trans-activates* the human [tumor necrosis factor-alpha] promoter . Positive_regulation TNF TCF3 8798568 381647 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by interleukin-1beta plus [tumor necrosis factor-alpha] , and its full induction *requires* the presence of the , c-FOS . Positive_regulation TNF TCF3 9792645 542591 [Tumor necrosis factor-alpha] *activation* of nuclear in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha . Positive_regulation TNF TCF3 9852224 554668 Altered binding of the NF-GMa is *involved* in the upregulated production of [TNF-alpha] by macrophages of mammary tumor bearing mice . Positive_regulation TNF TCF4 10200294 605481 A novel lipopolysaccharide induced *regulating* [tumor necrosis factor] alpha gene expression : molecular cloning , sequencing , characterization , and chromosomal assignment . Positive_regulation TNF TCF4 10792947 689509 Serum [tumor necrosis factor (TNF)] protein ( ELISA ) , hepatic TNF mRNA ( reverse transcription polymerase chain reaction ) , and hepatic *activation* of the nuclear factor kappa B ( electrophoretic mobility shift assay ) were also determined . Positive_regulation TNF TCF4 12091427 960138 Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB , whereas [TNF-alpha] potently *induced* this . Positive_regulation TNF TCF4 12161100 971827 Expression of [TNF-alpha] and IL-6 was *regulated* by a , nuclear factor (NF)-kappaB . Positive_regulation TNF TCF4 12890427 1117253 At the molecular level , EXPLY-37 did not inhibit the *activation* of the nuclear factor kappa B (NF-kappaB) by [TNF] . Positive_regulation TNF TCF4 14646597 1173190 [TNF-alpha] *induced* activation of both c-jun NH ( 2 ) -terminal kinase ( JNK ) and nuclear ( NF-kappaB ) in 3T3-L1 cells . Positive_regulation TNF TCF4 16006484 1459256 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of [TNF-alpha] , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TNF TCF4 16046706 1438314 Palmitate activates the NF-kappaB and *induces* IL-6 and [TNFalpha] expression in 3T3-L1 adipocytes . Positive_regulation TNF TCF4 17035338 1674540 Taken together , our data suggest that the [TNF-alpha] produced in response to IFN-gamma is *required* for iNOS induction by activating NF-kappaB . Positive_regulation TNF TCF4 18554501 1929370 Lipopolysaccharide induced TNF-alpha factor ( LITAF ) , a , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Positive_regulation TNF TCF4 1906501 161740 An NF-kappa B-like *mediates* [IL-1/TNF-alpha] induction of gro in human fibroblasts . Positive_regulation TNF TCF4 19479048 2085732 [TNFalpha] signaling is *mediated* by the , Nuclear Factor (NF)-kappaB , which regulates genes controlling several physiological processes including the innate immune responses , cell death , and inflammation . Positive_regulation TNF TCF4 19487969 2185529 In addition , lung injury in the Ron TK-deficient ( TK ( -/- ) ) mice was associated with increased activation of the , nuclear factor-kappaB (NF-kappaB) , and significantly *increased* intrapulmonary expression of [TNFalpha] . Positive_regulation TNF TCF4 21389273 2443514 Functionally , TNF-a stimulated H ( 2 ) O ( 2 ) production was also blocked by MCD and DES ( 194.6 ± 15.4 % vs. 90.6 ± 15.9 % and 148.8 ± 20.4 % ) , and the *activation* of the pivotal proinflammatory , NF-?B , by [TNF-a] was reversed by MCD and DES as well as by small interfering RNAs of Duox1 or ASMase . Positive_regulation TNF TCF4 24223737 2865193 Furthermore , rJHP0290 induced [TNF] release was partly *dependent* on activation of nuclear ( NF-?B ) . Positive_regulation TNF TCF4 8725122 373830 The adenoviral , E1A 13S , *trans-activates* the human [tumor necrosis factor-alpha] promoter . Positive_regulation TNF TCF4 8798568 381648 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by interleukin-1beta plus [tumor necrosis factor-alpha] , and its full induction *requires* the presence of the , c-FOS . Positive_regulation TNF TCF4 9792645 542592 [Tumor necrosis factor-alpha] *activation* of nuclear in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha . Positive_regulation TNF TCF4 9852224 554669 Altered binding of the NF-GMa is *involved* in the upregulated production of [TNF-alpha] by macrophages of mammary tumor bearing mice . Positive_regulation TNF TCF7 10200294 605482 A novel lipopolysaccharide induced *regulating* [tumor necrosis factor] alpha gene expression : molecular cloning , sequencing , characterization , and chromosomal assignment . Positive_regulation TNF TCF7 10792947 689510 Serum tumor necrosis factor (TNF) protein ( ELISA ) , hepatic [TNF] mRNA ( reverse transcription polymerase chain reaction ) , and hepatic *activation* of the nuclear factor kappa B ( electrophoretic mobility shift assay ) were also determined . Positive_regulation TNF TCF7 12091427 960139 Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB , whereas [TNF-alpha] potently *induced* this . Positive_regulation TNF TCF7 12161100 971828 Expression of [TNF-alpha] and IL-6 was *regulated* by a , nuclear factor (NF)-kappaB . Positive_regulation TNF TCF7 12890427 1117254 At the molecular level , EXPLY-37 did not inhibit the *activation* of the nuclear factor kappa B (NF-kappaB) by [TNF] . Positive_regulation TNF TCF7 14646597 1173191 [TNF-alpha] *induced* activation of both c-jun NH ( 2 ) -terminal kinase ( JNK ) and nuclear ( NF-kappaB ) in 3T3-L1 cells . Positive_regulation TNF TCF7 16006484 1459257 We monitored pulmonary vascular resistance , oxygenation , neutrophil count , lung edema as reflected by wet-dry weights of lung tissue , perfusate concentrations of [TNF-alpha] , IL-6 , and 8-isoprostane ( a marker of oxidative stress ) , and *activation* of the ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin . Positive_regulation TNF TCF7 16046706 1438315 Palmitate activates the NF-kappaB and *induces* IL-6 and [TNFalpha] expression in 3T3-L1 adipocytes . Positive_regulation TNF TCF7 17035338 1674541 Taken together , our data suggest that the [TNF-alpha] produced in response to IFN-gamma is *required* for iNOS induction by activating NF-kappaB . Positive_regulation TNF TCF7 18554501 1929371 Lipopolysaccharide induced TNF-alpha factor ( LITAF ) , a , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Positive_regulation TNF TCF7 1906501 161741 An NF-kappa B-like *mediates* [IL-1/TNF-alpha] induction of gro in human fibroblasts . Positive_regulation TNF TCF7 19479048 2085733 [TNFalpha] signaling is *mediated* by the , Nuclear Factor (NF)-kappaB , which regulates genes controlling several physiological processes including the innate immune responses , cell death , and inflammation . Positive_regulation TNF TCF7 19487969 2185530 In addition , lung injury in the Ron TK-deficient ( TK ( -/- ) ) mice was associated with increased activation of the , nuclear factor-kappaB (NF-kappaB) , and significantly *increased* intrapulmonary expression of [TNFalpha] . Positive_regulation TNF TCF7 21389273 2443515 Functionally , TNF-a stimulated H ( 2 ) O ( 2 ) production was also blocked by MCD and DES ( 194.6 ± 15.4 % vs. 90.6 ± 15.9 % and 148.8 ± 20.4 % ) , and the *activation* of the pivotal proinflammatory , NF-?B , by [TNF-a] was reversed by MCD and DES as well as by small interfering RNAs of Duox1 or ASMase . Positive_regulation TNF TCF7 24223737 2865194 Furthermore , rJHP0290 induced [TNF] release was partly *dependent* on activation of nuclear ( NF-?B ) . Positive_regulation TNF TCF7 8725122 373831 The adenoviral , E1A 13S , *trans-activates* the human [tumor necrosis factor-alpha] promoter . Positive_regulation TNF TCF7 8798568 381649 Expression of the murine collagenase , which is possibly the counterpart of human collagenase-3 , is induced by interleukin-1beta plus [tumor necrosis factor-alpha] , and its full induction *requires* the presence of the , c-FOS . Positive_regulation TNF TCF7 9792645 542593 [Tumor necrosis factor-alpha] *activation* of nuclear in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha . Positive_regulation TNF TCF7 9852224 554670 Altered binding of the NF-GMa is *involved* in the upregulated production of [TNF-alpha] by macrophages of mammary tumor bearing mice . Positive_regulation TNF TCL4 23151948 2757464 Here , H-1PV induced significantly *enhanced* the [TNF-a] level by DCs after coculture . Positive_regulation TNF TCL6 23151948 2757465 Here , H-1PV induced significantly *enhanced* the [TNF-a] level by DCs after coculture . Positive_regulation TNF TCN1 23973554 2873377 *increased* the expression of TLR4 and the EphB1 receptor , the activation of astrocytes and microglial cells , and increased levels of interleukin-1ß (IL-1ß) and [tumor necrosis factor-a (TNF-a)] . Positive_regulation TNF TCN1 23973554 2873382 The induced *activation* of astrocytes and microglial cells , as well as the increased levels of IL-1ß and [TNF-a] , were inhibited by intrathecal administration of TLR4 targeting siRNA2 and the EphB receptor antagonist EphB2-Fc , respectively . Positive_regulation TNF TDGF1P3 11529937 853682 Furthermore , [TNF-alpha] *induced* about a three-fold increase in the expression of in neutrophils , an effect which is blocked by the p38 MAPK inhibitor . Positive_regulation TNF TDGF1P3 8898723 393100 Macrophage phagocytosis of myelin in vitro determined by flow cytometry : phagocytosis is mediated by and *induces* production of [tumor necrosis factor-alpha] and nitric oxide . Positive_regulation TNF TDGF1P3 9574560 502555 This study was undertaken to evaluate the *role* of CD14 and and 4 ( CR4 ) in mediating [TNF] release and NF-kappaB activation induced by LPS and cell wall preparations from group B streptococci type III ( GBS ) . Positive_regulation TNF TEC 1902846 156092 On the other hand , [TNF alpha] plus IFN gamma *induced* HLA-DR expression on both types of thyroid xenografts at death , although IL-2 alone did not induce HLA-DR expression , and IFN gamma induced TEC significantly only on normal thyroid xenografts ( but not on Graves ' xenografts ) . Positive_regulation TNF TEC 9647261 515006 By comparison , [TNF-alpha] *induces* apoptosis in MC , but not , of the MRL-Fas ( lpr ) strain . Positive_regulation TNF TERT 15020249 1221497 [TNFalpha] *induces* rapid activation and nuclear translocation of in human lymphocytes . Positive_regulation TNF TERT 15326480 1296845 The present study described that , in the leukemic KG1 cells , [TNFalpha] *induced* no apoptosis but a senescence state characterized by prolonged growth arrest , increased beta-galactosidase activity , p21WAF-1 induction , decreased activity , telomeric disturbances ( shortening , losses , fusions ) , and additional chromosomal aberrations . Positive_regulation TNF TF 3066504 102725 [TNF] *induced* a rapid increase in the binding of to the cell surface , followed by a return to the basal level within 5 min . Positive_regulation TNF TFPI 11776329 890645 We recently reported that recombinant tissue factor pathway inhibitor ( ) , an important inhibitor of the extrinsic pathway of the coagulation system , *inhibits* [TNF-alpha] production by monocytes . Positive_regulation TNF TFPI 15217748 1263784 All cytokines peaked from 3 h to 6 h . and Nor *had* comparable effects on the expression of IL-6 , IL-8 and [TNF-a] in monocytes . Positive_regulation TNF TFPI 22471594 2624524 Dobu , , Nor , and LPS significantly *increased* BNP concentration but not [TNF-a] , IL-1ß , or IL-6 . Positive_regulation TNF TFPI 9021920 413141 *had* no effect on [TNF] receptor expression . Positive_regulation TNF TFPT 10755704 682797 *induced* [TNFalpha] expression in the livers of both WT and TRK mice to a similar extent ( 3-4 fold over control ) ; Positive_regulation TNF TFPT 10755704 682798 however , a corresponding increase of cellular NFkappaB , expected after the downstream cellular signaling of TNFalpha , was noted only in the WT. Accumulation of liver sphingosine after FB1 treatment was similar in both WT and TRK , but the FB1 induced increases in liver sphinganine and kidney sphingosine and sphinganine were lower in TRK than in WT. Results emphasized the role of TNFalpha in *induced* hepatotoxicity in mice and the possible relationship of sphingoid base accumulation and [TNFalpha] induction . Positive_regulation TNF TFPT 10959799 726310 The mRNA for TNFalpha in liver increased in both TG and WT after FB1 treatment , providing evidence that *induces* hepatic [TNFalpha] expression . Positive_regulation TNF TFPT 11250056 793691 *induced* the expression of [TNFalpha] , and similar increases in free sphinganine and sphingosine in livers of both WT and TNFRKO mice . Positive_regulation TNF TFPT 11437650 832867 Results indicate that *induced* increase in [TNFalpha] expression is independent of sphingoid base accumulation induced by ceramide synthase inhibition in LLC-PK1 cells . Positive_regulation TNF TFPT 12393292 1007899 *induced* the expression of [TNFalpha] in the liver of all strains , except the animals with a deleted TNFalpha gene . Positive_regulation TNF TFPT 12639295 1068688 The *induction* of [TNF-alpha] and interleukin-12 (IL-12) p40 by in liver was less in GKO mice compared with WT animals . Positive_regulation TNF TFPT 15103051 1266311 however , it prevented the *induced* increases in [TNF-alpha] , TNF receptor 1 , TNF receptor associated apoptosis inducing ligand , lymphotoxin beta , and interferon gamma . Positive_regulation TNF TFPT 15499968 1326845 In addition , an increase in caspase 3 activity was observed after addition of FB1 for 1 h. Calphostin C prevented both the *induced* increase in [TNFalpha] expression and caspase 3 activation . Positive_regulation TNF TFPT 15499968 1326847 In summary , we hereby demonstrate that the activation of NF-kappaB and sequential *induction* of [TNFalpha] expression resulting in the subsequent increase in caspase 3 activity are all dependent on PKCalpha stimulation in LLC-PK1 cells . Positive_regulation TNF TFPT 15590129 1356309 Decreased *induced* sphinganine accumulation and increased protective [TNFalpha] signaling by gadolinium chloride may in part account for its ameliorating effect on FB1 liver damage . Positive_regulation TNF TFPT 16054185 1447829 Anti-TNFalpha antibodies did not alter *induced* accumulation of free sphingoid bases or expression of [TNFalpha] in liver following the FB1 treatment . Positive_regulation TNF TFPT 16159691 1475887 The NZBW strain lacked the *induced* increases in the expression of liver tumor necrosis factor alpha , interferon gamma , receptor interacting protein ( RIP ) , and [tumor necrosis factor] alpha related apoptosis inducing ligand ( TRAIL ) , observed in CBL . Positive_regulation TNF TFPT 22761190 2623149 The supernatants were harvested 24 h after the induction and measured for cytokines by using enzyme linked immunosorbent assay . *induced* a dose dependent increase in the production of [tumor necrosis factor-a] and interleukin-1ß in both AGS and SW742 cell lines . Positive_regulation TNF TFRC 15614194 1387627 We analyzed reactive oxygen intermediate ( ROI ) production by peripheral blood granulocytes , the production of IL-2 , IL-5 , IL-10 , IL-12 , and [TNF-alpha] cytokines by lymphocytes , and the *activation* of CD25 , CD26 , CD69 , , and HLA DR antigen expression . Positive_regulation TNF TFRC 1921451 168511 [TNF] *induced* expression of CD4 and , increased the intensity of HLA-DR , CD25 , CD11c and CD13 expression and decreased both the intensity and frequency of sIg and cIg positivity . Positive_regulation TNF TG 12404274 1009778 [TNF-alpha] also *induced* increased secretion and reduced VEGF secretion by anaplastic tumor cells . Positive_regulation TNF TGFA 17182889 1709253 In early embryos , [TNF] *induces* apoptosis , whereas could act as a survival factor . Positive_regulation TNF TGFA 8349617 227076 Expression of keratinocyte SL-2 was also *induced* by the two keratinocyte growth factors , and epidermal growth factor , by the proinflammatory cytokine , [tumor necrosis factor-alpha] , but , somewhat surprisingly , not by interleukin-1 beta . Positive_regulation TNF TGFB1 10678961 668335 Although there were no changes in the mRNA levels for the anti-inflammatory cytokines interleukin-1 receptor agonist (IL-1ra) , IL-13 , and , the expression and secretion of the proinflammatory cytokines IL-6 , IL-8 , and [tumor necrosis factor alpha (TNF-alpha)] were significantly *induced* by both wild-type C. rectus and CrsA ( - ) bacteria . Positive_regulation TNF TGFB1 11310848 804852 suppresses [tumor necrosis factor] alpha *induced* matrix metalloproteinase-9 expression in monocytes . Positive_regulation TNF TGFB1 11502094 847437 TNF-alpha , PDGF , and TGF-beta(1) expression by primary mouse bronchiolar-alveolar epithelial and mesenchymal cells : [tnf-alpha] *induces* . Positive_regulation TNF TGFB1 11747628 889308 Our results showed significantly *increased* [TNF-alpha] secretion by monocytes . Positive_regulation TNF TGFB1 11937570 928254 The suppressive effect of IL-9 on the respiratory burst and [TNF-alpha] production in LPS stimulated monocytes was significantly *inhibited* by , but not by anti-IL-10Rbeta mAb . Positive_regulation TNF TGFB1 12480499 1024219 In sharp contrast , , in the presence of GM-CSF , dramatically *up-regulated* the expression of [TNF-alpha] and TGF-beta 1 mRNA . Positive_regulation TNF TGFB1 12901826 1118848 The secretion of [TNF-alpha] by HMPC increased after incubation with 100 mg/L erythromycin for 3 or 5 days , and the secretion of *increased* markedly after incubation with lower or higher concentrations of erythromycin . Positive_regulation TNF TGFB1 1442930 204995 Human amnion cells in monolayer culture were treated with interleukin-1 , [tumor necrosis factor] , or vehicle in the *presence* or absence of . Positive_regulation TNF TGFB1 15557315 1355276 Interestingly , *induced* IL-10 and [TNFalpha] secretion . Positive_regulation TNF TGFB1 15653932 1381616 [Tumor necrosis factor-alpha] *induces* expression in lung fibroblasts through the extracellular signal regulated kinase pathway . Positive_regulation TNF TGFB1 16249231 1553517 The immunohistological findings of a limited sample suggest a *role* for BM in sacroiliitis , for [TNFalpha] and IL6 in early , active lesions , and for at the time of secondary cartilage and bone proliferation . Positive_regulation TNF TGFB1 17173255 1662384 Since [TNF-alfa] and IL-10 are involved in regulation of inflammation , and can *induce* fibrosis and renal insufficiency - dominant features of end-stage renal disease ( ESRD ) , we explored the hypothesis that polymorphisms of these cytokine genes may be possible genetic susceptibility factors for the progression of renal failure . Positive_regulation TNF TGFB1 1717497 166798 the production by leukemic cells of IL-1 beta and [TNF-alpha] was significantly *promoted* by . Positive_regulation TNF TGFB1 17202225 1702412 *enhances* respiratory syncytial virus replication and [tumor necrosis factor] alpha induction in human epithelial cells . Positive_regulation TNF TGFB1 17932374 1866398 Finally , our studies further demonstrated that TGF-beta(1) induces p21 via a TNF-alpha signaling pathway and that p21 is a negative modulator of *induced* [TNF-alpha] expression . Positive_regulation TNF TGFB1 18179739 1838859 Alveolar macrophages ( AMs ) exposed to asbestos are well known to produce [TNF-alpha] , which *induces* the production of , leading to lung fibrogenesis . Positive_regulation TNF TGFB1 18569384 1929873 The latent form of is *induced* by [TNFalpha] through an ERK specific pathway and is activated by asbestos derived reactive oxygen species in vitro and in vivo . Positive_regulation TNF TGFB1 19830740 2169958 strongly reduced NK cell *mediated* tumor cell lysis and production of pro-inflammatory cytokines such as [TNF-alpha] and IFN-gamma . Positive_regulation TNF TGFB1 20141610 2178966 [TNF-alpha] *induces* expression in lung fibroblasts at the transcriptional level via AP-1 activation . Positive_regulation TNF TGFB1 2104224 150530 Furthermore , when a panel of stimuli were compared for their ability to induce IL 1 , [TNF] and IL 6 in the *presence* or absence of , IL 6 levels were augmented in the presence of TGF beta 1 , while the induction of IL 1 and TNF was inhibited significantly . Positive_regulation TNF TGFB1 2242500 144870 The studies suggest that IL-1 , IL-4 , or [TNF-alpha] *mediate* a proliferative signal on murine thymocytes independent of IL-6 and that the proliferative signals provided by these cytokines as well as IL-6 are inhibitable by rHu . Positive_regulation TNF TGFB1 9186223 436772 Titanium , cobalt , and chromium at concentrations ranging from 0.01 to 100 ng/ml significantly *enhanced* the release of interleukin-1 beta and [tumor necrosis factor-alpha] by lipopolysaccharide stimulated human osteogenic sarcoma cells , whereas they did not alter the release of . Positive_regulation TNF TGFB1 9369823 464066 This study suggests that interleukin-10 and can *regulate* [tumor necrosis factor-alpha] release from amniochorion under different conditions and by a different mechanism . Positive_regulation TNF TGFB1 9802563 544018 In addition , also *acted* directly on the intermediate stage of DC to prevent their over-maturation , which results in a preferential decrease in MHC class II , but not in CD86 , in the presence of [TNF-alpha] . Positive_regulation TNF TGFB2 10678961 668336 Although there were no changes in the mRNA levels for the anti-inflammatory cytokines interleukin-1 receptor agonist (IL-1ra) , IL-13 , and , the expression and secretion of the proinflammatory cytokines IL-6 , IL-8 , and [tumor necrosis factor alpha (TNF-alpha)] were significantly *induced* by both wild-type C. rectus and CrsA ( - ) bacteria . Positive_regulation TNF TGFB2 11310848 804853 suppresses [tumor necrosis factor] alpha *induced* matrix metalloproteinase-9 expression in monocytes . Positive_regulation TNF TGFB2 1442930 204996 Human amnion cells in monolayer culture were treated with interleukin-1 , [tumor necrosis factor] , or vehicle in the *presence* or absence of . Positive_regulation TNF TGFB2 17202225 1702413 *enhances* respiratory syncytial virus replication and [tumor necrosis factor] alpha induction in human epithelial cells . Positive_regulation TNF TGFB2 9369823 464067 This study suggests that interleukin-10 and can *regulate* [tumor necrosis factor-alpha] release from amniochorion under different conditions and by a different mechanism . Positive_regulation TNF TGFB3 10678961 668337 Although there were no changes in the mRNA levels for the anti-inflammatory cytokines interleukin-1 receptor agonist (IL-1ra) , IL-13 , and , the expression and secretion of the proinflammatory cytokines IL-6 , IL-8 , and [tumor necrosis factor alpha (TNF-alpha)] were significantly *induced* by both wild-type C. rectus and CrsA ( - ) bacteria . Positive_regulation TNF TGFB3 11310848 804854 suppresses [tumor necrosis factor] alpha *induced* matrix metalloproteinase-9 expression in monocytes . Positive_regulation TNF TGFB3 1442930 204997 Human amnion cells in monolayer culture were treated with interleukin-1 , [tumor necrosis factor] , or vehicle in the *presence* or absence of . Positive_regulation TNF TGFB3 17202225 1702414 *enhances* respiratory syncytial virus replication and [tumor necrosis factor] alpha induction in human epithelial cells . Positive_regulation TNF TGFB3 9369823 464068 This study suggests that interleukin-10 and can *regulate* [tumor necrosis factor-alpha] release from amniochorion under different conditions and by a different mechanism . Positive_regulation TNF TGIF1 20064471 2177666 Notably , we found that activation of [TNF-alpha] signaling *induced* the association of with Itch/AIP4 , resulting in increased accessibility of cFlip ( L ) for association and ubiquitination by Itch/AIP4 . Positive_regulation TNF THBS1 23954950 2861942 The mediated *increase* in [TNF-a] production was abolished in TLR4-deficient macrophages , suggesting that TSP1 activates macrophages through a TLR4 dependent pathway . Positive_regulation TNF THRA 10625622 658571 NF-kappaB was activated after the stimulation of TRAP , bFGF , and TNF-alpha in electrophoretic mobility shift assay , and E5510 suppressed the NF-kappaB activation *induced* by and bFGF but not the activation by [TNF-alpha] . Positive_regulation TNF THRAP3 10625622 658575 NF-kappaB was activated after the stimulation of TRAP , bFGF , and TNF-alpha in electrophoretic mobility shift assay , and E5510 suppressed the NF-kappaB activation *induced* by and bFGF but not the activation by [TNF-alpha] . Positive_regulation TNF TIE1 10969034 728329 [Tumor necrosis factor-alpha] *induced* in a time- and dose dependent fashion in all 3 EC types ( HUVEC , 2.3-fold ; Positive_regulation TNF TIFA 10920205 722516 IL-1 , but not [tumor necrosis factor] , *induces* complex formation in a ligand dependent manner . Positive_regulation TNF TIFA 11798190 902339 Our results suggest that is *involved* in the [TNF] mediated signaling by its interaction with TRAF2 . Positive_regulation TNF TIMP1 16288749 1484452 Interestingly , [TNFalpha] and IL-6 *induced* protein secretion more than 3- and 2-fold , respectively . Positive_regulation TNF TIMP3 19082505 2018330 [TNF-alpha] production and the bioavailability of its receptors on the cell surface are *regulated* by TACE ( TNF-alpha converting enzyme ) , a pleiotropic metalloprotease also known as ADAM17 , and its specific inhibitor . Positive_regulation TNF TIMP3 9749945 533251 [TNF-alpha] had no effect on the TIMP-1 and TIMP-2 mRNA levels and did not *induce* or TIMP-4 expression . Positive_regulation TNF TIMP4 9749945 533252 [TNF-alpha] had no effect on the TIMP-1 and TIMP-2 mRNA levels and did not *induce* TIMP-3 or expression . Positive_regulation TNF TIRAP 14630816 1210102 In contrast , in macrophages neither MyD88 , , nor I kappa B kinase 2 (IKK2) are *required* for NF-kappa B activation or [tumor necrosis factor alpha (TNF alpha)] , IL-6 , or IL-8 production , although Mal/TIRAP is still involved in the production of interferon beta (IFN beta) . Positive_regulation TNF TIRAP 17255320 1691067 In addition , overexpression of dominant negative forms of MyD88 and significantly *down-regulated* the spontaneous production of cytokines [tumor necrosis factor-alpha] , IL-6 , and vascular endothelial growth factor , and enzymes MMP-1 , MMP-2 , MMP-3 , and MMP-13 in RA synovial membrane cell cultures . Positive_regulation TNF TLR1 11238656 790943 Together , these data suggest that Mtb induced [TNF-alpha] production is largely *dependent* on signaling . Positive_regulation TNF TLR1 12133979 967084 Moreover , various ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* NF-kappa B activation and up-regulated [TNF-alpha] production in osteoclast precursor cells . Positive_regulation TNF TLR1 15611271 1357355 Furthermore , different ligands *stimulated* IL-6 and [TNF-alpha] production via signaling pathways , which showed unique characteristics . Positive_regulation TNF TLR1 15949138 1421207 Differences between newborns and adults with respect to *induced* [TNF-alpha] release extend to a range of TLR agonists , including bacterial lipopeptides , and are due to differences in soluble factors present in blood plasma . Positive_regulation TNF TLR1 15994412 1446958 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for [tumor necrosis factor] ( TNF-alpha ) , interleukin 6 , nitric oxide synthase-II ( iNOS ) , and NADPH oxidase 2 (Nox2) . Positive_regulation TNF TLR1 16426002 1515702 Although a number of variables influence ligand *induced* [TNF] responses , this assay can be optimized for potential clinical use to screen patients with primary immunodeficiencies affecting TLR function . Positive_regulation TNF TLR1 16538507 1574459 binding *results* in cell signal transduction and subsequent production of various proinflammatory cytokines such as IL-1 and [TNF-alpha] . Positive_regulation TNF TLR1 16713974 1564990 We report that IFN-gamma augments *induction* of [TNFalpha] by ligands , immune complexes , and zymosan by suppressing IL-10 production and thereby interrupting Stat3 mediated feedback inhibition . Positive_regulation TNF TLR1 16849509 1588488 We have previously reported that despite normal basal expression of TLRs and associated signaling intermediates , human neonatal cord blood monocytes demonstrate severe impairment in [TNF-alpha] production in *response* to triacylated ( ) and diacylated ( TLR 2/6 ) bacterial lipopeptides ( BLPs ) . Positive_regulation TNF TLR1 16887962 1596658 In wild-type macrophages , TREM-2 knockdown increased *induced* [TNF] production . Positive_regulation TNF TLR1 17467812 1737393 stimulation of RA-FLS also *induced* the production of IL-1beta and [TNF-alpha] to a lesser extent ; Positive_regulation TNF TLR1 17496895 1744431 Here we document a function for the TNF family member 4-1BB ligand (4-1BBL) in sustaining *induced* [TNF] production . Positive_regulation TNF TLR1 17523427 1746073 Observed changes in *dependent* [TNF-alpha] production can play important role in pathogenesis of CVID . Positive_regulation TNF TLR1 17652449 1793634 *induced* [TNF-alpha] , IL-1beta , and IL-10 production is mediated through MyD88 , whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta . Positive_regulation TNF TLR1 17907168 1812684 Moreover , we found that IFNgamma induced BAFF synthesis is inhibited by simultaneous *stimulation* with either ligands or [TNFalpha] . Positive_regulation TNF TLR1 18713972 1950757 A number of recent studies show that activation of CR3 on dendritic cells (DCs) suppresses *induced* [TNF-alpha] and IL-12 production and inhibits effective Ag presentation . Positive_regulation TNF TLR1 18713972 1950787 *induced* [TNF-alpha] and IL-12 production by bone marrow derived DCs occurs heterogeneously , with apoptotic cells inhibiting only certain populations depending on the TLR agonist . Positive_regulation TNF TLR1 18806225 1969743 *induced* [TNF] and IL-1 production are normal in macrophages derived from spin mice . Positive_regulation TNF TLR1 19322177 2064441 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ) , but not [TNF] , in *response* to ligands . Positive_regulation TNF TLR1 19454685 2084523 activation *induces* [TNF-alpha] production from adult neural stem/progenitor cells . Positive_regulation TNF TLR1 19890037 2165874 MAPKs are crucial for [TNF-alpha] and IL-6 production by innate immune cells in *response* to ligands . Positive_regulation TNF TLR1 20148136 2208400 Although [TNFalpha] secretion by adipose cells is probably *induced* , most notably by ligands , the activation and secretion pathways of this cytokine are not yet entirely understood . Positive_regulation TNF TLR1 20218345 2223495 Patients with AP demonstrated increased production of [TNFalpha] *induced* by and TLR4 ligands . Positive_regulation TNF TLR1 20337718 2273171 WNV infection or agonist treatment of gammadelta T cells *induced* the production of IFN-gamma , [tumor necrosis factor-alpha] and IL-6 , which are known to promote DC maturation . Positive_regulation TNF TLR1 20542322 2284800 *induced* [TNF-alpha] and IFN-alpha production by PBMCs was impaired in the patient and his brother . Positive_regulation TNF TLR1 20588172 2285763 Responses by THP-1 cells to TLR stimulation were quantified using Quanti-Blue colometric assay , and *induced* [tumor necrosis factor-alpha] production of primary monocytes was quantified by intracellular cytokine staining using flow cytometry . Positive_regulation TNF TLR1 21968712 2617032 In this report , we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages , leading to incapability for the production of inflammatory cytokines like [tumor necrosis factor (TNF)-a] and interleukin (IL)-1ß in *response* to stimulation . Positive_regulation TNF TLR1 22042224 2540113 Activation of *leads* to activation of NF-?B and release of proinflammatory cytokines , such as IL-6 and [TNF-a] . Positive_regulation TNF TLR1 22116836 2529919 signals *increased* levels of interferon ( IFN ) ß and [tumor necrosis factor (TNF)] a transcripts in the brains of infected mice and both TNF-a and IFN-a/ß , receptors promoted T-cell and trypanosoma infiltration into the brain parenchyma . Positive_regulation TNF TLR1 22345668 2572012 Knockdown of hnRNP U expression greatly attenuated *induced* expression of [TNF-a] , IL-6 , and IL-1ß , but not IL-12 , whereas hnRNP U overexpression greatly increased TLR induced expression of TNF-a , IL-6 , and IL-1ß . Positive_regulation TNF TLR1 22440523 2600806 The expression of *induced* production of [TNF-a] , IFN-a , IL-6 , and IL-12 were measured by multicolor flow cytometry . Positive_regulation TNF TLR1 22986631 2720015 Further , we demonstrated that *induced* [tumor necrosis factor-a] and interferon-ß contributed to the differential phagocytosis of apoptotic neutrophils and bacteria by macrophages . Positive_regulation TNF TLR1 23264656 2732516 We found that [TNF] *induced* surface TLR2 expression and augmented induced cytokine production in P. gingivalis stimulated BMDM , establishing a previously unidentified TNF dependent feedback loop . Positive_regulation TNF TLR1 23504259 2809757 Adenosine signaling suppresses the *dependent* expression of [TNF-a] , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Positive_regulation TNF TLR1 24205068 2864710 We compared *induced* production of pro-interleukin (IL)-1ß , IL-6 , and [tumor necrosis factor (TNF)-a] between 2-month-old infants and adults . Positive_regulation TNF TLR1 24771857 2937062 At the cellular level , Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower [TNF-a] and higher IL-10 in *response* to ligands than did their WT counterparts . Positive_regulation TNF TLR10 11238656 790951 Together , these data suggest that Mtb induced [TNF-alpha] production is largely *dependent* on signaling . Positive_regulation TNF TLR10 12133979 967092 Moreover , various ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* NF-kappa B activation and up-regulated [TNF-alpha] production in osteoclast precursor cells . Positive_regulation TNF TLR10 15611271 1357363 Furthermore , different ligands *stimulated* IL-6 and [TNF-alpha] production via signaling pathways , which showed unique characteristics . Positive_regulation TNF TLR10 15949138 1421215 Differences between newborns and adults with respect to *induced* [TNF-alpha] release extend to a range of TLR agonists , including bacterial lipopeptides , and are due to differences in soluble factors present in blood plasma . Positive_regulation TNF TLR10 15994412 1446966 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for [tumor necrosis factor] ( TNF-alpha ) , interleukin 6 , nitric oxide synthase-II ( iNOS ) , and NADPH oxidase 2 (Nox2) . Positive_regulation TNF TLR10 16426002 1515710 Although a number of variables influence ligand *induced* [TNF] responses , this assay can be optimized for potential clinical use to screen patients with primary immunodeficiencies affecting TLR function . Positive_regulation TNF TLR10 16538507 1574467 binding *results* in cell signal transduction and subsequent production of various proinflammatory cytokines such as IL-1 and [TNF-alpha] . Positive_regulation TNF TLR10 16713974 1564998 We report that IFN-gamma augments *induction* of [TNFalpha] by ligands , immune complexes , and zymosan by suppressing IL-10 production and thereby interrupting Stat3 mediated feedback inhibition . Positive_regulation TNF TLR10 16887962 1596666 In wild-type macrophages , TREM-2 knockdown increased *induced* [TNF] production . Positive_regulation TNF TLR10 17467812 1737401 stimulation of RA-FLS also *induced* the production of IL-1beta and [TNF-alpha] to a lesser extent ; Positive_regulation TNF TLR10 17496895 1744439 Here we document a function for the TNF family member 4-1BB ligand (4-1BBL) in sustaining *induced* [TNF] production . Positive_regulation TNF TLR10 17523427 1746081 Observed changes in *dependent* [TNF-alpha] production can play important role in pathogenesis of CVID . Positive_regulation TNF TLR10 17652449 1793642 *induced* [TNF-alpha] , IL-1beta , and IL-10 production is mediated through MyD88 , whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta . Positive_regulation TNF TLR10 17907168 1812692 Moreover , we found that IFNgamma induced BAFF synthesis is inhibited by simultaneous *stimulation* with either ligands or [TNFalpha] . Positive_regulation TNF TLR10 18713972 1950765 A number of recent studies show that activation of CR3 on dendritic cells (DCs) suppresses *induced* [TNF-alpha] and IL-12 production and inhibits effective Ag presentation . Positive_regulation TNF TLR10 18713972 1950795 *induced* [TNF-alpha] and IL-12 production by bone marrow derived DCs occurs heterogeneously , with apoptotic cells inhibiting only certain populations depending on the TLR agonist . Positive_regulation TNF TLR10 18806225 1969751 *induced* [TNF] and IL-1 production are normal in macrophages derived from spin mice . Positive_regulation TNF TLR10 19322177 2064449 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ) , but not [TNF] , in *response* to ligands . Positive_regulation TNF TLR10 19454685 2084531 activation *induces* [TNF-alpha] production from adult neural stem/progenitor cells . Positive_regulation TNF TLR10 19890037 2165882 MAPKs are crucial for [TNF-alpha] and IL-6 production by innate immune cells in *response* to ligands . Positive_regulation TNF TLR10 20148136 2208408 Although [TNFalpha] secretion by adipose cells is probably *induced* , most notably by ligands , the activation and secretion pathways of this cytokine are not yet entirely understood . Positive_regulation TNF TLR10 20337718 2273179 WNV infection or agonist treatment of gammadelta T cells *induced* the production of IFN-gamma , [tumor necrosis factor-alpha] and IL-6 , which are known to promote DC maturation . Positive_regulation TNF TLR10 20542322 2284808 *induced* [TNF-alpha] and IFN-alpha production by PBMCs was impaired in the patient and his brother . Positive_regulation TNF TLR10 20588172 2285771 Responses by THP-1 cells to TLR stimulation were quantified using Quanti-Blue colometric assay , and *induced* [tumor necrosis factor-alpha] production of primary monocytes was quantified by intracellular cytokine staining using flow cytometry . Positive_regulation TNF TLR10 21968712 2617040 In this report , we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages , leading to incapability for the production of inflammatory cytokines like [tumor necrosis factor (TNF)-a] and interleukin (IL)-1ß in *response* to stimulation . Positive_regulation TNF TLR10 22042224 2540121 Activation of *leads* to activation of NF-?B and release of proinflammatory cytokines , such as IL-6 and [TNF-a] . Positive_regulation TNF TLR10 22116836 2529927 signals *increased* levels of interferon ( IFN ) ß and [tumor necrosis factor (TNF)] a transcripts in the brains of infected mice and both TNF-a and IFN-a/ß , receptors promoted T-cell and trypanosoma infiltration into the brain parenchyma . Positive_regulation TNF TLR10 22345668 2572020 Knockdown of hnRNP U expression greatly attenuated *induced* expression of [TNF-a] , IL-6 , and IL-1ß , but not IL-12 , whereas hnRNP U overexpression greatly increased TLR induced expression of TNF-a , IL-6 , and IL-1ß . Positive_regulation TNF TLR10 22440523 2600814 The expression of *induced* production of [TNF-a] , IFN-a , IL-6 , and IL-12 were measured by multicolor flow cytometry . Positive_regulation TNF TLR10 22986631 2720023 Further , we demonstrated that *induced* [tumor necrosis factor-a] and interferon-ß contributed to the differential phagocytosis of apoptotic neutrophils and bacteria by macrophages . Positive_regulation TNF TLR10 23264656 2732524 We found that [TNF] *induced* surface TLR2 expression and augmented induced cytokine production in P. gingivalis stimulated BMDM , establishing a previously unidentified TNF dependent feedback loop . Positive_regulation TNF TLR10 23504259 2809766 Adenosine signaling suppresses the *dependent* expression of [TNF-a] , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Positive_regulation TNF TLR10 24205068 2864718 We compared *induced* production of pro-interleukin (IL)-1ß , IL-6 , and [tumor necrosis factor (TNF)-a] between 2-month-old infants and adults . Positive_regulation TNF TLR10 24771857 2937070 At the cellular level , Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower [TNF-a] and higher IL-10 in *response* to ligands than did their WT counterparts . Positive_regulation TNF TLR2 11160251 781577 Here we show that LPS , [TNF-alpha] , or IFN-gamma *induce* expression in both human dermal microvessel EC and HUVEC . Positive_regulation TNF TLR2 11238656 790944 Together , these data suggest that Mtb induced [TNF-alpha] production is largely *dependent* on signaling . Positive_regulation TNF TLR2 12025532 944306 The results suggest that gabexate mesilate induced inhibition of [tumour necrosis factor-alpha (TNF-alpha)] and interleukin-18 (IL-18) production in LPS stimulated PBMCs is *due* to the inhibition of the nuclear factor-kappa B activation pathway and/or inhibition of the processing pathway of pro-TNF-alpha and pro-IL-18 , not to down-regulation of or TLR-4 . Positive_regulation TNF TLR2 12133979 967085 Moreover , various ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* NF-kappa B activation and up-regulated [TNF-alpha] production in osteoclast precursor cells . Positive_regulation TNF TLR2 12691617 1080368 LPS-TLR4 adapted human THP-1 promonocytic cells cross-adapt to lipoteichoic acid <(LTA)-TLR2> *induced* [IL-1beta/TNF-alpha] production , suggesting disruption of a common intracellular signaling event ( s ) . Positive_regulation TNF TLR2 12875990 1115265 C57BL/10ScN ( TLR4 deletion mutant ) macrophages produce [TNFalpha] in *response* to , 3 , 7 , and 9 agonists , but not the TLR4 agonist E. coli LPS . Positive_regulation TNF TLR2 12875990 1115267 While adenosine and A ( 2A ) R agonists strongly down-regulate [TNFalpha] protein expression *induced* by , 3 , 4 , 7 , and 9 agonists , TNFalpha mRNA and NF-kappaB activation are not reduced . Positive_regulation TNF TLR2 15096475 1244257 In *response* to , -4 and -5 engagement , approximately 50 % of monocytes produced [TNF-alpha] , compared to only 5 % after induction with IFN-gamma or GM-CSF . Positive_regulation TNF TLR2 15294983 1279072 Short-term exposure ( < 6 h ) to LprG stimulated *dependent* [TNF-alpha] production . Positive_regulation TNF TLR2 15522205 1329205 These signals are required for optimal production of [TNFalpha] in *response* to stimulation , and are absent in macrophages from TLR4 mutant animals . Positive_regulation TNF TLR2 15611271 1357356 Furthermore , different ligands *stimulated* IL-6 and [TNF-alpha] production via signaling pathways , which showed unique characteristics . Positive_regulation TNF TLR2 15910421 1411980 The interaction of LPPG with and TLR4 *resulted* in activation of NF-kappaB and release of interleukin (IL)-10 , IL-12p40 , [tumour necrosis factor (TNF)-alpha] , and IL-8 from human monocytes . Positive_regulation TNF TLR2 15949138 1421208 Differences between newborns and adults with respect to *induced* [TNF-alpha] release extend to a range of TLR agonists , including bacterial lipopeptides , and are due to differences in soluble factors present in blood plasma . Positive_regulation TNF TLR2 15955814 1434497 SaeLM induced a *dependent* production of [tumor necrosis factor-alpha (TNF-alpha)] by human THP-1 monocyte/macrophage cell lines and interestingly was found to be the strongest inducer of this pro-inflammatory cytokine when compared with other LAM/LM-like molecules . Positive_regulation TNF TLR2 15994412 1446959 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for [tumor necrosis factor] ( TNF-alpha ) , interleukin 6 , nitric oxide synthase-II ( iNOS ) , and NADPH oxidase 2 (Nox2) . Positive_regulation TNF TLR2 16116224 1449067 regulation of [TNF] *requires* for post-transcriptional control , but not for transcriptional induction ; Positive_regulation TNF TLR2 16129673 1482308 The CD11b/CD18 binding activity played a contributory role to *dependent* induction of [tumor necrosis factor-alpha] by fimbriae but was involved in specific down-regulation of interleukin-12 . Positive_regulation TNF TLR2 16272176 1532151 The enhanced upregulation in AMphi *augmented* the expression of macrophage inflammatory protein-2 , [TNF-alpha] , and macrophage migration inhibitory factor in the AMphi in response to sequential challenges of LPS and peptidoglycan , a prototypical TLR2 ligand , which physiologically associated with amplified AMphi induced PMN migration into air pouch and lung alveoli . Positive_regulation TNF TLR2 16426002 1515703 Although a number of variables influence ligand *induced* [TNF] responses , this assay can be optimized for potential clinical use to screen patients with primary immunodeficiencies affecting TLR function . Positive_regulation TNF TLR2 16522399 1531293 The 70-kd heat shock protein is released from cells in mid-trimester amniotic fluid as a *consequence* of stimulation and potentiates [tumor necrosis factor-alpha] production . Positive_regulation TNF TLR2 16538507 1574460 binding *results* in cell signal transduction and subsequent production of various proinflammatory cytokines such as IL-1 and [TNF-alpha] . Positive_regulation TNF TLR2 16713974 1564991 We report that IFN-gamma augments *induction* of [TNFalpha] by ligands , immune complexes , and zymosan by suppressing IL-10 production and thereby interrupting Stat3 mediated feedback inhibition . Positive_regulation TNF TLR2 16825490 1632014 We determined that mitogen activated protein kinase (MAPK) activation and [tumor necrosis factor-alpha (TNF-alpha)] production in macrophage infected with Mycobacterium avium or M smegmatis is *dependent* on myeloid differentiation factor 88 ( MyD88 ) and but not TLR4 , MR , or CR3 . Positive_regulation TNF TLR2 16825490 1632056 Interestingly , the *mediated* production of [TNF-alpha] by macrophages infected with M smegmatis required the beta-glucan receptor dectin-1 . Positive_regulation TNF TLR2 16849509 1588489 We have previously reported that despite normal basal expression of TLRs and associated signaling intermediates , human neonatal cord blood monocytes demonstrate severe impairment in [TNF-alpha] production in *response* to triacylated ( TLR 2/1 ) and diacylated ( ) bacterial lipopeptides ( BLPs ) . Positive_regulation TNF TLR2 16879256 1593958 Cultured TECs grown from healthy mice produced the cytokines [TNF-alpha] and KC in *response* to stimulation by LPS and synthetic and TLR4 agonists . Positive_regulation TNF TLR2 16887962 1596659 In wild-type macrophages , TREM-2 knockdown increased *induced* [TNF] production . Positive_regulation TNF TLR2 17219971 1664141 mRNA , TLR4 mRNA , IL-6 and [TNF-alpha] could be *detected* with low value in normal controls , but they were up-regulated markedly on the 1st day after admission . Positive_regulation TNF TLR2 17266936 1697004 These results indicate that possibly *cause* the induction of [TNFalpha] expression in visceral fat tissues , being associated with the development of high fat induced insulin resistance . Positive_regulation TNF TLR2 17467812 1737394 stimulation of RA-FLS also *induced* the production of IL-1beta and [TNF-alpha] to a lesser extent ; Positive_regulation TNF TLR2 17496895 1744432 Here we document a function for the TNF family member 4-1BB ligand (4-1BBL) in sustaining *induced* [TNF] production . Positive_regulation TNF TLR2 17523427 1746074 Observed changes in *dependent* [TNF-alpha] production can play important role in pathogenesis of CVID . Positive_regulation TNF TLR2 17579034 1763706 lysate and specific TLR stimuli in vitro did not induce synergistic effects on cytokine synthesis , PBMC started to respond to subsequent TLR-4 and stimulation with significantly ( p < 0.05 ) *increased* [TNF-alpha] and reduced IL-10 production following increasing periods of preincubation with P.f . Positive_regulation TNF TLR2 17637846 1770797 [TNF-alpha-induction] was TLR4- and *dependent* for live but not for killed B. abortus . Positive_regulation TNF TLR2 17652449 1793635 *induced* [TNF-alpha] , IL-1beta , and IL-10 production is mediated through MyD88 , whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta . Positive_regulation TNF TLR2 17907168 1812685 Moreover , we found that IFNgamma induced BAFF synthesis is inhibited by simultaneous *stimulation* with either ligands or [TNFalpha] . Positive_regulation TNF TLR2 18256754 1839712 The production of [TNF-alpha] and IFN-alpha cytokines by peripheral blood mononuclears in *response* to stimulation by , TLR4 , TLR5 , TLR9 ligands ( zymosan , LPS , flagellin , and CpG-oligodeoxynucleotide , respectively ) was studied in donors and patients with common variable immunodeficiency . Positive_regulation TNF TLR2 18550705 1945934 The inhibition of signaling by dominant negative myeloid differentiation factor 88 ( MyD88 ) *blocked* [TNF-alpha] expression response to mechanical stress . Positive_regulation TNF TLR2 18624355 1941910 Although engagement *induced* the production of [TNF] , this cytokine as well as nitric oxide and superoxide molecules were not necessary for TLR2 mediated bacteriostasis . Positive_regulation TNF TLR2 18713972 1950758 A number of recent studies show that activation of CR3 on dendritic cells (DCs) suppresses *induced* [TNF-alpha] and IL-12 production and inhibits effective Ag presentation . Positive_regulation TNF TLR2 18713972 1950788 *induced* [TNF-alpha] and IL-12 production by bone marrow derived DCs occurs heterogeneously , with apoptotic cells inhibiting only certain populations depending on the TLR agonist . Positive_regulation TNF TLR2 18773284 2028346 Combined and NOD2 stimulation *induced* a four-fold higher secretion of [TNFalpha] and a 13-fold higher secretion of IL-1 beta in patients . Positive_regulation TNF TLR2 18806225 1969744 *induced* [TNF] and IL-1 production are normal in macrophages derived from spin mice . Positive_regulation TNF TLR2 19122641 2019503 By activating : TLR6 complexes and *inducing* [TNF-alpha] secretion by myeloid cells , versican strongly enhances LLC metastatic growth . Positive_regulation TNF TLR2 19250704 2182417 These data indicate that LTA dependent activation in odontoblasts and pulp fibroblasts , in contrast to immature DCs , does not *lead* to significant [TNF-alpha] and IL-1beta production , but that all three cell types influence the pulp inflammatory/immune response through CXCL8 synthesis and secretion . Positive_regulation TNF TLR2 19322177 2064442 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ) , but not [TNF] , in *response* to ligands . Positive_regulation TNF TLR2 19428561 2077078 The aim of this study was to determine whether stimulation of , TLR4 , and TLR6 by their specific ligands *induces* the production of [tumor necrosis factor-alpha (TNF-alpha)] in fibroblast-like synoviocytes ( FLS ) from interleukin-1 receptor antagonist ( IL-1Ra ) -deficient mice . Positive_regulation TNF TLR2 19428561 2077081 Stimulation of , TLR4 , and TLR6 by their specific ligands *increased* the production of [TNF-alpha] in FLS from IL-1Ra-deficient mice . Positive_regulation TNF TLR2 19454685 2084524 activation *induces* [TNF-alpha] production from adult neural stem/progenitor cells . Positive_regulation TNF TLR2 19570869 2122082 In contrast , iPPVO induced [TNF-alpha] release and enhanced expression of MHC-I and CD86 but not of MHC-II by BMDC chiefly *requires* MyD88 but not or TLR4 . Positive_regulation TNF TLR2 19797072 2159387 In macrophages , TLR4 and the adaptor molecule MyD88 , but not or TLR5 , are *required* for [tumor necrosis factor] alpha production induced by B. thailandensis . Positive_regulation TNF TLR2 19874421 2488986 Mutations of two tyrosine residues in the GR , 598 and 663 , to phenylalanine significantly reduced interaction with PI3K and the GC effects on *induced* [TNF-a] expression . Positive_regulation TNF TLR2 19890037 2165875 MAPKs are crucial for [TNF-alpha] and IL-6 production by innate immune cells in *response* to ligands . Positive_regulation TNF TLR2 20016198 2247954 Apically added LGG , and NOD2 ligands , but not Bb , *enhanced* IFN-gamma , IL-12 and/or [TNF-alpha] secretion . Positive_regulation TNF TLR2 20148136 2208401 Although [TNFalpha] secretion by adipose cells is probably *induced* , most notably by ligands , the activation and secretion pathways of this cytokine are not yet entirely understood . Positive_regulation TNF TLR2 20337718 2273172 WNV infection or agonist treatment of gammadelta T cells *induced* the production of IFN-gamma , [tumor necrosis factor-alpha] and IL-6 , which are known to promote DC maturation . Positive_regulation TNF TLR2 20542322 2284801 *induced* [TNF-alpha] and IFN-alpha production by PBMCs was impaired in the patient and his brother . Positive_regulation TNF TLR2 20588172 2285764 Responses by THP-1 cells to TLR stimulation were quantified using Quanti-Blue colometric assay , and *induced* [tumor necrosis factor-alpha] production of primary monocytes was quantified by intracellular cytokine staining using flow cytometry . Positive_regulation TNF TLR2 20837170 2336728 Lapachol did not affect resting , IFN-?- or *induced* levels of oxygen and nitrogen metabolism key proteins nor the TLR2 mediated secretion of [TNF-a] , nor induced either oxidative or endoplasmic reticulum ( ER ) stress . Positive_regulation TNF TLR2 21717809 2447278 Silencing of *led* to a statistically significant inhibition of [TNF-alpha] secretion induced by TLR2 agonist while siRNA silencing of TLR4 did not affect the response to TLR2 agonist . Positive_regulation TNF TLR2 21717809 2447279 Silencing of *led* to a statistically significant inhibition of [TNF-a] secretion induced by CANTASTIM while silencing of TLR4 had no effect on the response to CANTASTIM . Positive_regulation TNF TLR2 21957307 2502640 By using small interfering RNA screening , we further demonstrated that , among the RIG-I-like receptors (RLRs) and Toll-like receptors ( TLRs ) , only , TLR6 , TLR7 , and TLR9 *contribute* to the NF-?B dependent secretion of [TNF] and the inflammasome dependent secretion of IL-1ß in response to vMyxM013-KO virus infection . Positive_regulation TNF TLR2 21968712 2617033 In this report , we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages , leading to incapability for the production of inflammatory cytokines like [tumor necrosis factor (TNF)-a] and interleukin (IL)-1ß in *response* to stimulation . Positive_regulation TNF TLR2 21998707 2493797 We found that the expression of [TNF-a] and IL-6 *induced* by engagement in uPAR-/- neutrophils was less than that in uPAR+/+ ( WT ) neutrophils . Positive_regulation TNF TLR2 22042224 2540114 Activation of *leads* to activation of NF-?B and release of proinflammatory cytokines , such as IL-6 and [TNF-a] . Positive_regulation TNF TLR2 22051147 2527813 Moreover , the joint production of [TNF-a] , IL-1ß and CXCL1/KC by zymosan was *dependent* on signaling . Positive_regulation TNF TLR2 22075930 2540665 Macrophage elicited osteoclastogenesis in response to Brucella abortus infection requires *dependent* [TNF-a] production . Positive_regulation TNF TLR2 22103323 2529652 The *dependent* [TNF-a] response of macrophages to heat killed lgt mutant bacteria was reduced . Positive_regulation TNF TLR2 22116836 2529920 signals *increased* levels of interferon ( IFN ) ß and [tumor necrosis factor (TNF)] a transcripts in the brains of infected mice and both TNF-a and IFN-a/ß , receptors promoted T-cell and trypanosoma infiltration into the brain parenchyma . Positive_regulation TNF TLR2 22207132 2549745 Efficient capture of Candida albicans and zymosan by SIGNR1 augments *dependent* [TNF-a] production . Positive_regulation TNF TLR2 22345668 2572013 Knockdown of hnRNP U expression greatly attenuated TLR induced expression of TNF-a , IL-6 , and IL-1ß , but not IL-12 , whereas hnRNP U overexpression greatly increased *induced* expression of [TNF-a] , IL-6 , and IL-1ß . Positive_regulation TNF TLR2 22440523 2600807 The expression of *induced* production of [TNF-a] , IFN-a , IL-6 , and IL-12 were measured by multicolor flow cytometry . Positive_regulation TNF TLR2 22986631 2720016 Further , we demonstrated that *induced* [tumor necrosis factor-a] and interferon-ß contributed to the differential phagocytosis of apoptotic neutrophils and bacteria by macrophages . Positive_regulation TNF TLR2 23233677 2731715 A pneumococcal mutant carrying RrgA with a deletion of the P3 region was significantly reduced in its ability to activate and *induce* [TNF-a] responses after mouse intraperitoneal infection , whereas no such difference could be noted when TLR2 ( -/- ) mice were challenged , further implicating this region in recognition by TLR2 . Positive_regulation TNF TLR2 23264656 2732517 We found that [TNF] *induced* surface TLR2 expression and augmented induced cytokine production in P. gingivalis stimulated BMDM , establishing a previously unidentified TNF dependent feedback loop . Positive_regulation TNF TLR2 23504259 2809758 Adenosine signaling suppresses the *dependent* expression of [TNF-a] , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Positive_regulation TNF TLR2 23929630 2909432 Studies reported an immunological response in pregnant women with primary HCMV infection and activity in collecting of HCMV particles in placental syncytiotrophoblasts (STs) in vivo and cultured ST , and in *stimulation* of [tumor necrosis factor (TNF)-a] expression and damage of villous trophoblast . Positive_regulation TNF TLR2 24205068 2864711 We compared *induced* production of pro-interleukin (IL)-1ß , IL-6 , and [tumor necrosis factor (TNF)-a] between 2-month-old infants and adults . Positive_regulation TNF TLR2 24771857 2937063 At the cellular level , Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower [TNF-a] and higher IL-10 in *response* to ligands than did their WT counterparts . Positive_regulation TNF TLR3 11238656 790945 Together , these data suggest that Mtb induced [TNF-alpha] production is largely *dependent* on signaling . Positive_regulation TNF TLR3 12133979 967086 Moreover , various ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* NF-kappa B activation and up-regulated [TNF-alpha] production in osteoclast precursor cells . Positive_regulation TNF TLR3 15611271 1357357 Furthermore , different ligands *stimulated* IL-6 and [TNF-alpha] production via signaling pathways , which showed unique characteristics . Positive_regulation TNF TLR3 15949138 1421209 Differences between newborns and adults with respect to *induced* [TNF-alpha] release extend to a range of TLR agonists , including bacterial lipopeptides , and are due to differences in soluble factors present in blood plasma . Positive_regulation TNF TLR3 15972671 1424139 signaling *resulted* in a more pronounced inflammatory response than did TLR4 , as evidenced by up-regulation of the transcription factor IFN regulatory factor-1 , chemokines IL-8 and RANTES , and the proinflammatory cytokine [TNF] . Positive_regulation TNF TLR3 15994412 1446960 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for [tumor necrosis factor] ( TNF-alpha ) , interleukin 6 , nitric oxide synthase-II ( iNOS ) , and NADPH oxidase 2 (Nox2) . Positive_regulation TNF TLR3 16426002 1515704 Although a number of variables influence ligand *induced* [TNF] responses , this assay can be optimized for potential clinical use to screen patients with primary immunodeficiencies affecting TLR function . Positive_regulation TNF TLR3 16537619 1536817 IFN-alpha and [TNF-alpha] *induced* the expression of the RIG-I , , MyD88 , TRIF , and IRF7 genes , whereas no detectable TLR7 and TLR8 was seen in A549 cells . Positive_regulation TNF TLR3 16538507 1574461 binding *results* in cell signal transduction and subsequent production of various proinflammatory cytokines such as IL-1 and [TNF-alpha] . Positive_regulation TNF TLR3 16713974 1564992 We report that IFN-gamma augments *induction* of [TNFalpha] by ligands , immune complexes , and zymosan by suppressing IL-10 production and thereby interrupting Stat3 mediated feedback inhibition . Positive_regulation TNF TLR3 16887962 1596660 In wild-type macrophages , TREM-2 knockdown increased *induced* [TNF] production . Positive_regulation TNF TLR3 16954173 1627624 [TNF-alpha] and IFN-gamma *induced* TLR2 , and TLR6 mRNA in mesangial cells , while they down-regulated TLR1-9 mRNA in macrophages . Positive_regulation TNF TLR3 17196665 1732432 Meanwhile , 24h after poly I:C injection , expression of was markedly elevated within decidua basalis ( DB ) , and endometrial [TNF-alpha] *increased* 2.7-fold but IFN-gamma remained unchanged in homogenized endometrium . Positive_regulation TNF TLR3 17467812 1737395 stimulation of RA-FLS also *induced* the production of IL-1beta and [TNF-alpha] to a lesser extent ; Positive_regulation TNF TLR3 17496895 1744433 Here we document a function for the TNF family member 4-1BB ligand (4-1BBL) in sustaining *induced* [TNF] production . Positive_regulation TNF TLR3 17523427 1746075 Observed changes in *dependent* [TNF-alpha] production can play important role in pathogenesis of CVID . Positive_regulation TNF TLR3 17652449 1793636 *induced* [TNF-alpha] , IL-1beta , and IL-10 production is mediated through MyD88 , whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta . Positive_regulation TNF TLR3 17907168 1812686 Moreover , we found that IFNgamma induced BAFF synthesis is inhibited by simultaneous *stimulation* with either ligands or [TNFalpha] . Positive_regulation TNF TLR3 18713972 1950759 A number of recent studies show that activation of CR3 on dendritic cells (DCs) suppresses *induced* [TNF-alpha] and IL-12 production and inhibits effective Ag presentation . Positive_regulation TNF TLR3 18713972 1950789 *induced* [TNF-alpha] and IL-12 production by bone marrow derived DCs occurs heterogeneously , with apoptotic cells inhibiting only certain populations depending on the TLR agonist . Positive_regulation TNF TLR3 18806225 1969745 *induced* [TNF] and IL-1 production are normal in macrophages derived from spin mice . Positive_regulation TNF TLR3 19322177 2064443 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ) , but not [TNF] , in *response* to ligands . Positive_regulation TNF TLR3 19454685 2084525 activation *induces* [TNF-alpha] production from adult neural stem/progenitor cells . Positive_regulation TNF TLR3 19753301 2135339 Furthermore , these shRNA sequences specifically blocked TLR2 but not *dependent* [TNF-alpha] production . Positive_regulation TNF TLR3 19890037 2165876 MAPKs are crucial for [TNF-alpha] and IL-6 production by innate immune cells in *response* to ligands . Positive_regulation TNF TLR3 20148136 2208402 Although [TNFalpha] secretion by adipose cells is probably *induced* , most notably by ligands , the activation and secretion pathways of this cytokine are not yet entirely understood . Positive_regulation TNF TLR3 20337718 2273173 WNV infection or agonist treatment of gammadelta T cells *induced* the production of IFN-gamma , [tumor necrosis factor-alpha] and IL-6 , which are known to promote DC maturation . Positive_regulation TNF TLR3 20542322 2284802 *induced* [TNF-alpha] and IFN-alpha production by PBMCs was impaired in the patient and his brother . Positive_regulation TNF TLR3 20588172 2285765 Responses by THP-1 cells to TLR stimulation were quantified using Quanti-Blue colometric assay , and *induced* [tumor necrosis factor-alpha] production of primary monocytes was quantified by intracellular cytokine staining using flow cytometry . Positive_regulation TNF TLR3 21425908 2438383 and TLR4 stimulation *increased* the secretion of [TNF-a] , IL-6 , and RANTES/CCL5 , while activation of TLR2 caused a significant increase in nitric oxide levels . Positive_regulation TNF TLR3 21454254 2448140 *dependent* regulation of cytokines in human mesangial cells : a novel role for IP-10 and [TNF-alpha] in hepatitis C-associated glomerulonephritis . Positive_regulation TNF TLR3 21454254 2448144 In hepatitis C virus associated glomerulonephritis , analysis of interferon-?-inducible protein ( IP-10 ) as a chemokine centrally involved in early antiviral response and TNF-a known to balance proinflammatory and immunosuppressive effects in inflammation shows a significant upregulation of both IP-10 and [TNF-a] *mediated* specifically by the viral receptor expressed on mesangial cells . Positive_regulation TNF TLR3 21691053 2524005 Endosomal inhibition by chloroquine dose-dependently inhibited dsRNA induced TSLP generation and *reduced* generation of CXCL8 , [TNF-a] , and IFN-ß . Positive_regulation TNF TLR3 21968712 2617034 In this report , we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages , leading to incapability for the production of inflammatory cytokines like [tumor necrosis factor (TNF)-a] and interleukin (IL)-1ß in *response* to stimulation . Positive_regulation TNF TLR3 22042224 2540115 Activation of *leads* to activation of NF-?B and release of proinflammatory cytokines , such as IL-6 and [TNF-a] . Positive_regulation TNF TLR3 22116836 2529921 signals *increased* levels of interferon ( IFN ) ß and [tumor necrosis factor (TNF)] a transcripts in the brains of infected mice and both TNF-a and IFN-a/ß , receptors promoted T-cell and trypanosoma infiltration into the brain parenchyma . Positive_regulation TNF TLR3 22345668 2572014 Knockdown of hnRNP U expression greatly attenuated *induced* expression of [TNF-a] , IL-6 , and IL-1ß , but not IL-12 , whereas hnRNP U overexpression greatly increased TLR induced expression of TNF-a , IL-6 , and IL-1ß . Positive_regulation TNF TLR3 22440523 2600808 The expression of *induced* production of [TNF-a] , IFN-a , IL-6 , and IL-12 were measured by multicolor flow cytometry . Positive_regulation TNF TLR3 22986631 2720017 Further , we demonstrated that *induced* [tumor necrosis factor-a] and interferon-ß contributed to the differential phagocytosis of apoptotic neutrophils and bacteria by macrophages . Positive_regulation TNF TLR3 23264656 2732518 We found that [TNF] *induced* surface TLR2 expression and augmented induced cytokine production in P. gingivalis stimulated BMDM , establishing a previously unidentified TNF dependent feedback loop . Positive_regulation TNF TLR3 23504259 2809759 Adenosine signaling suppresses the *dependent* expression of [TNF-a] , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Positive_regulation TNF TLR3 24138989 2882712 Furthermore , from the optimized IRN , we confirmed 45 interactions between proteins in biological experiments and identified 37 new regulatory interactions and 8 false positive interactions , including the following interactions : IL1ß regulates TLR3 , *regulates* IFN-ß and [TNF] regulates IL6 . Positive_regulation TNF TLR3 24205068 2864712 We compared *induced* production of pro-interleukin (IL)-1ß , IL-6 , and [tumor necrosis factor (TNF)-a] between 2-month-old infants and adults . Positive_regulation TNF TLR3 24771857 2937064 At the cellular level , Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower [TNF-a] and higher IL-10 in *response* to ligands than did their WT counterparts . Positive_regulation TNF TLR4 11238656 790946 Together , these data suggest that Mtb induced [TNF-alpha] production is largely *dependent* on signaling . Positive_regulation TNF TLR4 11350737 814665 These data demonstrate that , like [TNF-alpha] , induction of MnSOD by LPS is *mediated* by mCD14 and in murine macrophages . Positive_regulation TNF TLR4 11739561 886589 Using these models , we demonstrated that the BMMC IL-6 and [TNF-alpha] responses to LPS were completely *dependent* on functional with no significant LPS response observed in its absence . Positive_regulation TNF TLR4 11801529 902550 Furthermore , up-regulation of TLR2 and CD14 mRNA expression by PMA was abrogated by a protein kinase C inhibitor , Calphostine C , suggesting the up-regulation of TLR2 and CD14 mRNA is dependent on the activation of protein kinase C. Coexpression of CD14/TLR2 and/or may be *essential* but not sufficient for the production of [tumor necrosis factor-alpha] in response to lipopolysaccharide in our system . Positive_regulation TNF TLR4 12025532 944307 The results suggest that gabexate mesilate induced inhibition of [tumour necrosis factor-alpha (TNF-alpha)] and interleukin-18 (IL-18) production in LPS stimulated PBMCs is *due* to the inhibition of the nuclear factor-kappa B activation pathway and/or inhibition of the processing pathway of pro-TNF-alpha and pro-IL-18 , not to down-regulation of TLR-2 or . Positive_regulation TNF TLR4 12133979 967087 Moreover , various ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* NF-kappa B activation and up-regulated [TNF-alpha] production in osteoclast precursor cells . Positive_regulation TNF TLR4 12759420 1091115 In conclusion , we show for the first time that production of NO and [TNF-alpha] is critically *dependent* on activation of by LPS during invasion of macrophages by salmonellae , but that different patterns of activation of intracellular signaling pathways are induced by purified LPS vs live salmonellae . Positive_regulation TNF TLR4 15325567 1287152 Incubation of explants with a neutralizing anti-toll-like receptor-4 monoclonal antibody was used to determine if lipopolysaccharide stimulation of [tumor necrosis factor] or interleukin-6 secretion was *dependent* on activity . Positive_regulation TNF TLR4 15501798 1327182 However , early [tumor necrosis factor alpha (TNF-alpha)] mRNA expression is primarily *dependent* on and in vitro and in vivo protein levels substantiate this finding . Positive_regulation TNF TLR4 15611271 1357358 Furthermore , different ligands *stimulated* IL-6 and [TNF-alpha] production via signaling pathways , which showed unique characteristics . Positive_regulation TNF TLR4 15784548 1386068 Acute aerosol exposures to wild-type strains of H. influenzae showed that function was *essential* for [TNF-alpha] induction , neutrophil influx , and bacterial clearance . Positive_regulation TNF TLR4 15792558 1386769 [ Differential modulation of TLR2 and *induced* [TNF] production by murin haemorrhagic shock ] . Positive_regulation TNF TLR4 15898987 1408679 These findings indicate that the production of [TNF-alpha] and IL-13 by LPS *required* signalling as a common pathway of mast cell mediated inflammation . Positive_regulation TNF TLR4 15910421 1411981 The interaction of LPPG with TLR2 and *resulted* in activation of NF-kappaB and release of interleukin (IL)-10 , IL-12p40 , [tumour necrosis factor (TNF)-alpha] , and IL-8 from human monocytes . Positive_regulation TNF TLR4 15949138 1421210 Differences between newborns and adults with respect to *induced* [TNF-alpha] release extend to a range of TLR agonists , including bacterial lipopeptides , and are due to differences in soluble factors present in blood plasma . Positive_regulation TNF TLR4 15994412 1446961 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for [tumor necrosis factor] ( TNF-alpha ) , interleukin 6 , nitric oxide synthase-II ( iNOS ) , and NADPH oxidase 2 (Nox2) . Positive_regulation TNF TLR4 16109884 1474086 HIV impairs [TNF-alpha] release in *response* to stimulation in human macrophages in vitro . Positive_regulation TNF TLR4 16319097 1546934 and MyD88 mRNA and proteins were *induced* by LPS and [TNF-alpha] in RA FLS . Positive_regulation TNF TLR4 16319097 1546941 We demonstrate that VIP down-regulates LPS and [TNF-alpha] *activation* of TLR4 expression and the functional response in terms of proinflammatory chemokine production . Positive_regulation TNF TLR4 16426002 1515705 Although a number of variables influence ligand *induced* [TNF] responses , this assay can be optimized for potential clinical use to screen patients with primary immunodeficiencies affecting TLR function . Positive_regulation TNF TLR4 16481293 1524641 activation *causes* partial hepatic I/R injury through release of [TNF-alpha] . Positive_regulation TNF TLR4 16517732 1530890 Bruton 's tyrosine kinase is required for TLR2 and *induced* [TNF] , but not IL-6 , production . Positive_regulation TNF TLR4 16517732 1530898 Furthermore , using the p38 inhibitor SB203580 , we show that the *induced* production of [TNF] , but not IL-6 , requires the activity of p38 MAPK . Positive_regulation TNF TLR4 16538507 1574462 binding *results* in cell signal transduction and subsequent production of various proinflammatory cytokines such as IL-1 and [TNF-alpha] . Positive_regulation TNF TLR4 16622195 1551601 Functional is *essential* for an efficient IL-1-beta , [TNF-alpha] , and IFN-gamma response ; Positive_regulation TNF TLR4 16713974 1564993 We report that IFN-gamma augments *induction* of [TNFalpha] by ligands , immune complexes , and zymosan by suppressing IL-10 production and thereby interrupting Stat3 mediated feedback inhibition . Positive_regulation TNF TLR4 16781673 1576867 In addition , activation of with either LPS or free fatty acids *stimulated* NFkappaB signaling and expression of inflammatory cytokine genes , such as [TNFalpha] and IL-6 in 3T3-L1 adipocytes . Positive_regulation TNF TLR4 16825490 1632015 We determined that mitogen activated protein kinase (MAPK) activation and [tumor necrosis factor-alpha (TNF-alpha)] production in macrophage infected with Mycobacterium avium or M smegmatis is *dependent* on myeloid differentiation factor 88 ( MyD88 ) and TLR2 but not , MR , or CR3 . Positive_regulation TNF TLR4 16887962 1596661 In wild-type macrophages , TREM-2 knockdown increased *induced* [TNF] production . Positive_regulation TNF TLR4 16951382 1610611 We show in this study that , in that regimen , hsp70 acts as a potent immune adjuvant through signaling and local *induction* of [TNF-alpha] . Positive_regulation TNF TLR4 17015691 1629825 Because endogenous TLR4 ligands are expressed in the rheumatoid joint , the TLR4 ligand LPS was used to characterize the effects of RANTES on the *mediated* induction of [TNF-alpha] and IL-6 . Positive_regulation TNF TLR4 17015691 1629829 In conclusion , the results of this study suggest that RANTES down-regulates ligation *induced* IL-6 and [TNF-alpha] secretion by enhancing IL-10 production in PB monocytes . Positive_regulation TNF TLR4 17034424 1683109 In this study we have shown that , whilst NF-kappaB activation and production of [TNF-alpha] and interleukin-12 by murine RAW264.7 and J774.2 cells in *response* to stimulation by , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or interleukin-12 responses to subsequent TLR stimulation . Positive_regulation TNF TLR4 17467812 1737396 stimulation of RA-FLS also *induced* the production of IL-1beta and [TNF-alpha] to a lesser extent ; Positive_regulation TNF TLR4 17496895 1744434 Here we document a function for the TNF family member 4-1BB ligand (4-1BBL) in sustaining *induced* [TNF] production . Positive_regulation TNF TLR4 17507094 1751006 Compared to the signaling data , while *induced* [TNFalpha] mRNA expression is not significantly inhibited by TRAF6 knockdown , TLR7 induced TNFalpha mRNA is significantly blocked . Positive_regulation TNF TLR4 17523427 1746076 Observed changes in *dependent* [TNF-alpha] production can play important role in pathogenesis of CVID . Positive_regulation TNF TLR4 17592223 1768213 Prolonged alcohol exposure also resulted in an increase in NF-kappaB and [TNFalpha] production in *response* to stimulation with LPS . Positive_regulation TNF TLR4 17652449 1793637 *induced* [TNF-alpha] , IL-1beta , and IL-10 production is mediated through MyD88 , whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta . Positive_regulation TNF TLR4 17907168 1812687 Moreover , we found that IFNgamma induced BAFF synthesis is inhibited by simultaneous *stimulation* with either ligands or [TNFalpha] . Positive_regulation TNF TLR4 18000954 1831520 The TLR4 pathway is likely involved , since gp105 activates signaling and *induces* [TNF-alpha] production by monocytes . Positive_regulation TNF TLR4 18028374 1866900 While in cells isolated from patients with Crohn 's disease with the wild-type NOD2 allele , the NOD2 engagement led to a similar cross-tolerance to *dependent* stimulation of [TNF-alpha] , the cross-tolerance between NOD2 and TLR4 was absent in the cells of five patients homozygous for the 3020insC NOD2 mutation , leading to uninhibited release of TNF-alpha by TLR4 ligands and intestinal bacteria . Positive_regulation TNF TLR4 18034866 1874384 Production of [TNF-alpha] and IL-6 was *dependent* on expression of as stimulation of macrophages from TLR4 ( -/- ) mice with S. Typhimurium did not result in expression of these cytokines . Positive_regulation TNF TLR4 18256754 1839715 Reduced stimulated production of [TNF-alpha] in *response* to stimulation with and TLR5 ligands in vitro was detected in patients with common variable immunodeficiency . Positive_regulation TNF TLR4 18271077 1865813 Stimulation with TLR2 , and TLR7/8 ligands , as well as TLR3 ligand , *resulted* in significantly lower production of [TNF-alpha] , but neither IL-6 nor IL-12p70 , by DCs from XLA patients in comparison to normal controls . Positive_regulation TNF TLR4 18421279 1915171 In contrast , deficiency did not *attenuate* the induction of [tumor necrosis factor-alpha (TNF-alpha)] or interleukin-6 (IL-6) expression in adipose tissue . Positive_regulation TNF TLR4 18442564 1900513 This study examined whether *regulates* [TNF-alpha] and interleukin (IL)-1beta peptide production during global ischemia/reperfusion and whether TLR4 signaling influences postischemic cardiac function through TNF-alpha and IL-1beta . Positive_regulation TNF TLR4 18442564 1900517 signaling *mediates* the production of [TNF-alpha] and IL-1beta peptides , and these two cytokines link TLR4 signaling to postischemic cardiac dysfunction . Positive_regulation TNF TLR4 18707748 1968085 The increased IFN-beta , IL-6 and [TNF-alpha] production was *mediated* by induction , since the introduction of the small interfering RNA against TLR4 specifically inhibited the HTNV induced cytokine production . Positive_regulation TNF TLR4 18713972 1950760 A number of recent studies show that activation of CR3 on dendritic cells (DCs) suppresses *induced* [TNF-alpha] and IL-12 production and inhibits effective Ag presentation . Positive_regulation TNF TLR4 18713972 1950790 *induced* [TNF-alpha] and IL-12 production by bone marrow derived DCs occurs heterogeneously , with apoptotic cells inhibiting only certain populations depending on the TLR agonist . Positive_regulation TNF TLR4 18806225 1969746 *induced* [TNF] and IL-1 production are normal in macrophages derived from spin mice . Positive_regulation TNF TLR4 18826950 1987987 In the current study , surface TLR4 expression were similar but activation ( lipid A , 10 microg/ml ) *resulted* in lower [TNF-alpha] release by HIV+ human macrophages compared with healthy cells . Positive_regulation TNF TLR4 19028791 2022897 FXR activation by natural and synthetic ligands in these cell types attenuated IL-1beta , IL-6 , and [TNF-alpha] gene induction in *response* to activation by LPS . Positive_regulation TNF TLR4 19294383 2119986 Downregulation of MyD88 and expression using small interfering RNA ( siRNA ) significantly *inhibited* gamma-PGA induced [TNF-alpha] secretion from the RAW264.7 cells . Positive_regulation TNF TLR4 19322177 2064444 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ) , but not [TNF] , in *response* to ligands . Positive_regulation TNF TLR4 19410299 2128201 Zymosan *enhanced* dectin-1/TLR2/TLR4 expression and [TNF-alpha/IL-10] production in all of three types of cell , whereas p-beta-glucan increased and TNF-alpha/IL-12 production in AMs but inhibited IL-10 in mDCs . Positive_regulation TNF TLR4 19428561 2077079 The aim of this study was to determine whether stimulation of toll-like receptor 2 (TLR2) , , and TLR6 by their specific ligands *induces* the production of [tumor necrosis factor-alpha (TNF-alpha)] in fibroblast-like synoviocytes ( FLS ) from interleukin-1 receptor antagonist ( IL-1Ra ) -deficient mice . Positive_regulation TNF TLR4 19428561 2077082 Stimulation of TLR2 , , and TLR6 by their specific ligands *increased* the production of [TNF-alpha] in FLS from IL-1Ra-deficient mice . Positive_regulation TNF TLR4 19454685 2084526 activation *induces* [TNF-alpha] production from adult neural stem/progenitor cells . Positive_regulation TNF TLR4 19753301 2135337 Recovery of shRNA sequences from surviving cells led to the identification of unique shRNA sequences that significantly inhibited *dependent* [TNF-alpha] gene expression . Positive_regulation TNF TLR4 19797072 2159388 In macrophages , and the adaptor molecule MyD88 , but not TLR2 or TLR5 , are *required* for [tumor necrosis factor] alpha production induced by B. thailandensis . Positive_regulation TNF TLR4 19828114 2184125 We conclude that neutrophil recruitment to the milk spaces is : ( i ) mediated through [TNFalpha] , which is produced by alveolar macrophages in *response* to LPS/ signaling and ( ii ) is dependent on IL8 and IL1beta signaling and regulated by iNOS derived NO . Positive_regulation TNF TLR4 19890037 2165877 MAPKs are crucial for [TNF-alpha] and IL-6 production by innate immune cells in *response* to ligands . Positive_regulation TNF TLR4 19955831 2224891 In contrast , TLR stimulated proinflammatory cytokine production was markedly higher in neonates than in adults , with the exception of *induced* [TNF-alpha] production . Positive_regulation TNF TLR4 20006396 2204338 *dependent* [TNF-alpha] production increased following antibiotic use ( 1077 vs. 3620pg/mL , p < 0.05 ) , whilst TLR2 dependent production was unchanged . Positive_regulation TNF TLR4 20018613 2191635 In the current study , we demonstrate that incubation of Prx1 with thioglycollate elicited murine macrophages or immature bone marrow derived dendritic cells resulted in *dependent* secretion of [TNF-alpha] and IL-6 and dendritic cell maturation . Positive_regulation TNF TLR4 20148136 2208403 Although [TNFalpha] secretion by adipose cells is probably *induced* , most notably by ligands , the activation and secretion pathways of this cytokine are not yet entirely understood . Positive_regulation TNF TLR4 20218345 2223496 Patients with AP demonstrated increased production of [TNFalpha] *induced* by TLR1/2 and ligands . Positive_regulation TNF TLR4 20337701 2273168 may be *involved* in [TNF-alpha] production from RAW264.7 cells and enhanced host resistance induced by p60 administration . Positive_regulation TNF TLR4 20337718 2273174 WNV infection or agonist treatment of gammadelta T cells *induced* the production of IFN-gamma , [tumor necrosis factor-alpha] and IL-6 , which are known to promote DC maturation . Positive_regulation TNF TLR4 20388086 2240169 It will be reported that LPS is able to *induce* [TNF-alpha] and NO release from cultured cardiomyocytes , while molecular and morphological evidence demonstrates the expression of on surface membrane of embryonal cardiomyocytes . Positive_regulation TNF TLR4 20442858 2256972 Our studies demonstrated that signaling is *required* for optimal production of IFN-gamma , [TNF-alpha] and nitric oxide ( NO ) in the spleen of infected animals and , as a consequence , Tlr4 ( -/- ) mice display higher parasitemia levels . Positive_regulation TNF TLR4 20465519 2339623 Our results show that the absence of functional *resulted* in lower chemotaxis of neutrophils to the site of infection , lower levels of [TNF-a] , CXCL1 and nitric oxide , and dissemination and persistence of the pathogen in lymph nodes and spleen . Positive_regulation TNF TLR4 20472010 2288546 Human monocytes and macrophages secreted tumor necrosis factor (TNF)-alpha in response to mmLDL , and blocking CD14 or *resulted* in a approximately 60 % decrease in mmLDL induced [TNF-alpha] secretion . Positive_regulation TNF TLR4 20506307 2307838 The activation of> *induced* [TNF-alpha] and IFN-alpha production by PBMCs was impaired in the patient and his brother . Positive_regulation TNF TLR4 20547845 2284905 A wholly synthetic 20-mer peptide containing cysteine 106 from within the cytokine stimulating B box mediates *dependent* activation of macrophage [TNF] release . Positive_regulation TNF TLR4 20550956 2315746 *Role* for in [TNF-alpha] secretion by murine macrophages in response to polysaccharide Krestin , a Trametes versicolor mushroom extract . Positive_regulation TNF TLR4 20588172 2285766 Responses by THP-1 cells to TLR stimulation were quantified using Quanti-Blue colometric assay , and *induced* [tumor necrosis factor-alpha] production of primary monocytes was quantified by intracellular cytokine staining using flow cytometry . Positive_regulation TNF TLR4 20850889 2395339 ligation of IEC ( HT-29 ) *enhanced* the production of [TNF-a] and IEC derived MDC and decreased numbers of Foxp3 ( + ) regulatory T cells . Positive_regulation TNF TLR4 20850889 2395340 Neutralization of TSLP abrogated *induced* [TNF-a] secretion . Positive_regulation TNF TLR4 20932871 2368948 CCAE300 ) prior to the administration of LPS ( 20 mg/kg bw , i.p. ) significantly suppressed the increased [tumor necrosis factor-a (TNF-a)] , interleukin-1ß (IL-1ß) and nitrite oxide ( NO ) in plasma as well as the *activation* of and nuclear factor-?B ( NF-?B ) in ileum . Positive_regulation TNF TLR4 20954191 2369336 Stimulation of [TNF] by cFb was *dependent* on and MyD88 , while stimulation by cFb-IC was dependent on both TLR-4/MyD88 and Fc?R . Positive_regulation TNF TLR4 21033154 2338863 To characterize the *role* of in silica induced production of [tumor necrosis factor alpha (TNFalpha)] from macrophage cell line . Positive_regulation TNF TLR4 21102427 2377310 LBH589 also significantly repressed the production of interleukin (IL)-6 , IL-10 , IL-12p70 , IL-23 and [tumor necrosis factor-a] by Toll-like receptor (TLR)3 and induced DC *activation* , indicating an important role of HDAC activity in immune regulation and inflammation . Positive_regulation TNF TLR4 21175809 2373697 Post-transplant , the two groups differed with regard to *dependent* [TNF-a] production , with rejectors demonstrating progressive downregulation over the first week . Positive_regulation TNF TLR4 21425908 2438384 TLR3 and stimulation *increased* the secretion of [TNF-a] , IL-6 , and RANTES/CCL5 , while activation of TLR2 caused a significant increase in nitric oxide levels . Positive_regulation TNF TLR4 21603190 2430826 Albumin produced a dose dependent and *dependent* increase in NF-?B activation and [TNF-a] gene expression in vitro . Positive_regulation TNF TLR4 21962237 2497780 Acute alcohol inhibited TLR8- or *induced* [TNF alpha] protein and mRNA induction while it augmented IL-10 production in monocytes . Positive_regulation TNF TLR4 21968712 2617035 In this report , we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages , leading to incapability for the production of inflammatory cytokines like [tumor necrosis factor (TNF)-a] and interleukin (IL)-1ß in *response* to stimulation . Positive_regulation TNF TLR4 22021612 2507971 Hck tyrosine kinase regulates *induced* [TNF] and IL-6 production via AP-1 . Positive_regulation TNF TLR4 22021612 2507973 Using primary human macrophages in combination with adenoviral overexpression and small interfering RNA knockdown studies , we show that the SFK , Hck , has a pre-eminent role in *induced* [TNF] and IL-6 production . Positive_regulation TNF TLR4 22021612 2507974 Hck kinase mediates *induced* transcription of both [TNF] and IL-6 by a mechanism that involves neither the NF-?B nor the MAPK pathways , but rather leads to AP-1 binding with a complex of c-fos and JunD . Positive_regulation TNF TLR4 22025552 2508027 Targeted gene silencing of MyD88 ( short hairpin RNA ) and mTOR ( RNA interference ) inhibition resulted in *mediated* 70-kDa ribosomal protein S6 kinase activation and enhanced [TNF-a] release , whereas IL-10 release was inhibited in both silenced and nonsilenced HIV ( + ) macrophages . Positive_regulation TNF TLR4 22042224 2540116 Activation of *leads* to activation of NF-?B and release of proinflammatory cytokines , such as IL-6 and [TNF-a] . Positive_regulation TNF TLR4 22116836 2529922 signals *increased* levels of interferon ( IFN ) ß and [tumor necrosis factor (TNF)] a transcripts in the brains of infected mice and both TNF-a and IFN-a/ß , receptors promoted T-cell and trypanosoma infiltration into the brain parenchyma . Positive_regulation TNF TLR4 22262768 2564508 Heme induces *dependent* production of [tumor necrosis factor (TNF)] , whereas heme cytotoxicity has been attributed to its ability to intercalate into cell membranes and cause oxidative stress . Positive_regulation TNF TLR4 22262768 2564510 Heme induced cell death required TNFR1 and *dependent* [TNF] production . Positive_regulation TNF TLR4 22262768 2564514 Taken together , these results revealed that heme induces macrophage necrosis through 2 synergistic mechanisms : *dependent* expression of [TNF] and TLR4 independent generation of ROS . Positive_regulation TNF TLR4 22302035 2624201 Our results indicate that Lyn plays a positive role in *induced* production of [TNF-a] in MCs controlling the activity of the TRAF-6/TAK-1 protein complex . Positive_regulation TNF TLR4 22319556 2553787 The current study was designed to investigate the mechanisms of this effect by determining whether ethanol inhibits TLR3 and *mediated* [TNF-a] secretion through inhibition of transcription factor activation or post-transcriptional effects . Positive_regulation TNF TLR4 22345668 2572015 Knockdown of hnRNP U expression greatly attenuated TLR induced expression of TNF-a , IL-6 , and IL-1ß , but not IL-12 , whereas hnRNP U overexpression greatly increased *induced* expression of [TNF-a] , IL-6 , and IL-1ß . Positive_regulation TNF TLR4 22440523 2600809 The expression of *induced* production of [TNF-a] , IFN-a , IL-6 , and IL-12 were measured by multicolor flow cytometry . Positive_regulation TNF TLR4 22685319 2675995 Interestingly , despite expression of TLR mRNA on Kupffer cells , ligation of , TLR7/8 , and TLR9 *resulted* in a weak induction of IL-10 , low or undetectable levels of IL-12p40 and [TNF] , and up-regulation of CD40 on the surface . Positive_regulation TNF TLR4 22749982 2734539 Induction of CD152 ( CTLA-4 ) and LAP ( TGF-ß1 ) in human Foxp3- CD4+ CD25- T cells modulates *induced* [TNF-a] production . Positive_regulation TNF TLR4 22782967 2660015 We found that acute alcohol pretreatment resulted in the same attenuating effect as LPS pretreatment on *induced* [TNF-a] production in human monocytes and murine RAW 264.7 macrophages . Positive_regulation TNF TLR4 22789921 2645400 inhibition decreased the severity of CFS and significantly *reduced* the mRNA expression of IL-1ß , IL-6 , and [TNF] . Positive_regulation TNF TLR4 22890140 2672005 The results demonstrated that fewer neutrophils infiltrated in the myocardium of TLR4-mutant mice after myocardial I/R and that deficiency markedly decreased the ischemic injury caused by ischemia/reperfusion , and *inhibited* the expression of HMGB1 , [TNF-a] , and IL-8 , all of which were up-regulated by ischemia/reperfusion . Positive_regulation TNF TLR4 22982140 2716100 In addition , was *required* for the optimal production of IL-6 , [TNF-a] , and IL-12 in BMDCs in response to A. baumannii . Positive_regulation TNF TLR4 22986631 2720018 Further , we demonstrated that *induced* [tumor necrosis factor-a] and interferon-ß contributed to the differential phagocytosis of apoptotic neutrophils and bacteria by macrophages . Positive_regulation TNF TLR4 23071790 2690034 Hb alone can elicit the *dependent* secretion of [TNF-a] from macrophages , so it may be the TLR4 ligand . Positive_regulation TNF TLR4 23264656 2732519 We found that [TNF] *induced* surface TLR2 expression and augmented induced cytokine production in P. gingivalis stimulated BMDM , establishing a previously unidentified TNF dependent feedback loop . Positive_regulation TNF TLR4 23504259 2809760 Adenosine signaling suppresses the *dependent* expression of [TNF-a] , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Positive_regulation TNF TLR4 23595503 2800063 Thus , a reduced CD14 ( + ) CD16 ( + ) activated/differentiated monocyte subset and a correspondingly lower level of functional on monocytes *contributes* to the relatively low [TNF-a] response to LPS observed in immunologically naive newborns compared to the response in adults . Positive_regulation TNF TLR4 23669238 2823324 These data indicate that SR-A is *required* for maximal production of [TNF-a] in cells stimulated with LPS , possibly by modulating the cell surface levels of and CD14 . Positive_regulation TNF TLR4 23724117 2793250 TLR9 induced IFNA1 secretion as well as *induced* [TNF] secretion from PBMCs was dose-dependently attenuated by coincubation with epinephrine . Positive_regulation TNF TLR4 23727604 2823595 The results showed that a lowered amount of cardiomyocyte apoptosis and infarct size in the myocardium of TLR4-mutant mice after myocardial I/R and that deficiency notably *inhibited* the expression of HMGB1 and [TNF-a] , both of which were up-regulated by ischemia/reperfusion . Positive_regulation TNF TLR4 23918981 2830775 The *stimulated* production of il6 and tnfa mRNA and IL-6 and [TNF-a] secretion was hardly affected , because the Toll/IL-1R domain containing adapter inducing IFN-ß ( TRIF ) signaling pathway was used instead of the IRAK2-TRAF6 interaction to sustain late-phase mRNA production . Positive_regulation TNF TLR4 23960234 2836084 In conclusion , our results show that activation of µ and d opioid receptors with morphine suppresses *induced* [TNF] release in mast cells , preventing the IKK dependent phosphorylation of SNAP-23 , which is necessary for TNF exocytosis , and this inhibition correlates with the formation of a ß-arrestin-2/TRAF6 complex . Positive_regulation TNF TLR4 24205068 2864713 We compared *induced* production of pro-interleukin (IL)-1ß , IL-6 , and [tumor necrosis factor (TNF)-a] between 2-month-old infants and adults . Positive_regulation TNF TLR4 24771857 2937065 At the cellular level , Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower [TNF-a] and higher IL-10 in *response* to ligands than did their WT counterparts . Positive_regulation TNF TLR4 25143807 2954683 Cyto B strongly suppressed the *mediated* mRNA expression of inflammatory genes such as cyclooxygenase (COX)-2 , [tumor necrosis factor (TNF)-a] , and inducible nitric oxide ( iNOS ) , without altering cell viability . Positive_regulation TNF TLR5 11238656 790947 Together , these data suggest that Mtb induced [TNF-alpha] production is largely *dependent* on signaling . Positive_regulation TNF TLR5 12133979 967088 Moreover , various ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* NF-kappa B activation and up-regulated [TNF-alpha] production in osteoclast precursor cells . Positive_regulation TNF TLR5 12794153 1098264 Although flagellin activation of the IL-1R associated kinase and induction of [TNF-alpha] synthesis are *dependent* on and not TLR4 , we have found that flagellin stimulates NO in macrophages via a pathway that requires TLR5 and TLR4 . Positive_regulation TNF TLR5 15611271 1357359 Furthermore , different ligands *stimulated* IL-6 and [TNF-alpha] production via signaling pathways , which showed unique characteristics . Positive_regulation TNF TLR5 15949138 1421211 Differences between newborns and adults with respect to *induced* [TNF-alpha] release extend to a range of TLR agonists , including bacterial lipopeptides , and are due to differences in soluble factors present in blood plasma . Positive_regulation TNF TLR5 15994412 1446962 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for [tumor necrosis factor] ( TNF-alpha ) , interleukin 6 , nitric oxide synthase-II ( iNOS ) , and NADPH oxidase 2 (Nox2) . Positive_regulation TNF TLR5 16426002 1515706 Although a number of variables influence ligand *induced* [TNF] responses , this assay can be optimized for potential clinical use to screen patients with primary immunodeficiencies affecting TLR function . Positive_regulation TNF TLR5 16538507 1574463 binding *results* in cell signal transduction and subsequent production of various proinflammatory cytokines such as IL-1 and [TNF-alpha] . Positive_regulation TNF TLR5 16713974 1564994 We report that IFN-gamma augments *induction* of [TNFalpha] by ligands , immune complexes , and zymosan by suppressing IL-10 production and thereby interrupting Stat3 mediated feedback inhibition . Positive_regulation TNF TLR5 16887962 1596662 In wild-type macrophages , TREM-2 knockdown increased *induced* [TNF] production . Positive_regulation TNF TLR5 17467812 1737397 stimulation of RA-FLS also *induced* the production of IL-1beta and [TNF-alpha] to a lesser extent ; Positive_regulation TNF TLR5 17496895 1744435 Here we document a function for the TNF family member 4-1BB ligand (4-1BBL) in sustaining *induced* [TNF] production . Positive_regulation TNF TLR5 17523427 1746077 Observed changes in *dependent* [TNF-alpha] production can play important role in pathogenesis of CVID . Positive_regulation TNF TLR5 17652449 1793638 *induced* [TNF-alpha] , IL-1beta , and IL-10 production is mediated through MyD88 , whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta . Positive_regulation TNF TLR5 17907168 1812688 Moreover , we found that IFNgamma induced BAFF synthesis is inhibited by simultaneous *stimulation* with either ligands or [TNFalpha] . Positive_regulation TNF TLR5 18256754 1839716 Reduced stimulated production of [TNF-alpha] in *response* to stimulation with TLR4 and ligands in vitro was detected in patients with common variable immunodeficiency . Positive_regulation TNF TLR5 18713972 1950761 A number of recent studies show that activation of CR3 on dendritic cells (DCs) suppresses *induced* [TNF-alpha] and IL-12 production and inhibits effective Ag presentation . Positive_regulation TNF TLR5 18713972 1950791 *induced* [TNF-alpha] and IL-12 production by bone marrow derived DCs occurs heterogeneously , with apoptotic cells inhibiting only certain populations depending on the TLR agonist . Positive_regulation TNF TLR5 18806225 1969747 *induced* [TNF] and IL-1 production are normal in macrophages derived from spin mice . Positive_regulation TNF TLR5 19322177 2064445 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ) , but not [TNF] , in *response* to ligands . Positive_regulation TNF TLR5 19454685 2084527 activation *induces* [TNF-alpha] production from adult neural stem/progenitor cells . Positive_regulation TNF TLR5 19797072 2159389 In macrophages , TLR4 and the adaptor molecule MyD88 , but not TLR2 or , are *required* for [tumor necrosis factor] alpha production induced by B. thailandensis . Positive_regulation TNF TLR5 19890037 2165878 MAPKs are crucial for [TNF-alpha] and IL-6 production by innate immune cells in *response* to ligands . Positive_regulation TNF TLR5 20148136 2208404 Although [TNFalpha] secretion by adipose cells is probably *induced* , most notably by ligands , the activation and secretion pathways of this cytokine are not yet entirely understood . Positive_regulation TNF TLR5 20337718 2273175 WNV infection or agonist treatment of gammadelta T cells *induced* the production of IFN-gamma , [tumor necrosis factor-alpha] and IL-6 , which are known to promote DC maturation . Positive_regulation TNF TLR5 20542322 2284804 *induced* [TNF-alpha] and IFN-alpha production by PBMCs was impaired in the patient and his brother . Positive_regulation TNF TLR5 20588172 2285767 Responses by THP-1 cells to TLR stimulation were quantified using Quanti-Blue colometric assay , and *induced* [tumor necrosis factor-alpha] production of primary monocytes was quantified by intracellular cytokine staining using flow cytometry . Positive_regulation TNF TLR5 21968712 2617036 In this report , we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages , leading to incapability for the production of inflammatory cytokines like [tumor necrosis factor (TNF)-a] and interleukin (IL)-1ß in *response* to stimulation . Positive_regulation TNF TLR5 22042224 2540117 Activation of *leads* to activation of NF-?B and release of proinflammatory cytokines , such as IL-6 and [TNF-a] . Positive_regulation TNF TLR5 22116836 2529923 signals *increased* levels of interferon ( IFN ) ß and [tumor necrosis factor (TNF)] a transcripts in the brains of infected mice and both TNF-a and IFN-a/ß , receptors promoted T-cell and trypanosoma infiltration into the brain parenchyma . Positive_regulation TNF TLR5 22345668 2572016 Knockdown of hnRNP U expression greatly attenuated *induced* expression of [TNF-a] , IL-6 , and IL-1ß , but not IL-12 , whereas hnRNP U overexpression greatly increased TLR induced expression of TNF-a , IL-6 , and IL-1ß . Positive_regulation TNF TLR5 22440523 2600810 The expression of *induced* production of [TNF-a] , IFN-a , IL-6 , and IL-12 were measured by multicolor flow cytometry . Positive_regulation TNF TLR5 22986631 2720019 Further , we demonstrated that *induced* [tumor necrosis factor-a] and interferon-ß contributed to the differential phagocytosis of apoptotic neutrophils and bacteria by macrophages . Positive_regulation TNF TLR5 23264656 2732520 We found that [TNF] *induced* surface TLR2 expression and augmented induced cytokine production in P. gingivalis stimulated BMDM , establishing a previously unidentified TNF dependent feedback loop . Positive_regulation TNF TLR5 23504259 2809761 Adenosine signaling suppresses the *dependent* expression of [TNF-a] , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Positive_regulation TNF TLR5 24205068 2864714 We compared *induced* production of pro-interleukin (IL)-1ß , IL-6 , and [tumor necrosis factor (TNF)-a] between 2-month-old infants and adults . Positive_regulation TNF TLR5 24771857 2937066 At the cellular level , Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower [TNF-a] and higher IL-10 in *response* to ligands than did their WT counterparts . Positive_regulation TNF TLR6 11238656 790952 Together , these data suggest that Mtb induced [TNF-alpha] production is largely *dependent* on signaling . Positive_regulation TNF TLR6 12133979 967093 Moreover , various ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* NF-kappa B activation and up-regulated [TNF-alpha] production in osteoclast precursor cells . Positive_regulation TNF TLR6 15611271 1357364 Furthermore , different ligands *stimulated* IL-6 and [TNF-alpha] production via signaling pathways , which showed unique characteristics . Positive_regulation TNF TLR6 15949138 1421216 Differences between newborns and adults with respect to *induced* [TNF-alpha] release extend to a range of TLR agonists , including bacterial lipopeptides , and are due to differences in soluble factors present in blood plasma . Positive_regulation TNF TLR6 15994412 1446967 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for [tumor necrosis factor] ( TNF-alpha ) , interleukin 6 , nitric oxide synthase-II ( iNOS ) , and NADPH oxidase 2 (Nox2) . Positive_regulation TNF TLR6 16426002 1515711 Although a number of variables influence ligand *induced* [TNF] responses , this assay can be optimized for potential clinical use to screen patients with primary immunodeficiencies affecting TLR function . Positive_regulation TNF TLR6 16538507 1574468 binding *results* in cell signal transduction and subsequent production of various proinflammatory cytokines such as IL-1 and [TNF-alpha] . Positive_regulation TNF TLR6 16713974 1564999 We report that IFN-gamma augments *induction* of [TNFalpha] by ligands , immune complexes , and zymosan by suppressing IL-10 production and thereby interrupting Stat3 mediated feedback inhibition . Positive_regulation TNF TLR6 16849509 1588490 We have previously reported that despite normal basal expression of TLRs and associated signaling intermediates , human neonatal cord blood monocytes demonstrate severe impairment in [TNF-alpha] production in *response* to triacylated ( TLR 2/1 ) and diacylated ( ) bacterial lipopeptides ( BLPs ) . Positive_regulation TNF TLR6 16887962 1596667 In wild-type macrophages , TREM-2 knockdown increased *induced* [TNF] production . Positive_regulation TNF TLR6 17467812 1737402 stimulation of RA-FLS also *induced* the production of IL-1beta and [TNF-alpha] to a lesser extent ; Positive_regulation TNF TLR6 17496895 1744440 Here we document a function for the TNF family member 4-1BB ligand (4-1BBL) in sustaining *induced* [TNF] production . Positive_regulation TNF TLR6 17523427 1746082 Observed changes in *dependent* [TNF-alpha] production can play important role in pathogenesis of CVID . Positive_regulation TNF TLR6 17652449 1793643 *induced* [TNF-alpha] , IL-1beta , and IL-10 production is mediated through MyD88 , whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta . Positive_regulation TNF TLR6 17907168 1812693 Moreover , we found that IFNgamma induced BAFF synthesis is inhibited by simultaneous *stimulation* with either ligands or [TNFalpha] . Positive_regulation TNF TLR6 18713972 1950766 A number of recent studies show that activation of CR3 on dendritic cells (DCs) suppresses *induced* [TNF-alpha] and IL-12 production and inhibits effective Ag presentation . Positive_regulation TNF TLR6 18713972 1950796 *induced* [TNF-alpha] and IL-12 production by bone marrow derived DCs occurs heterogeneously , with apoptotic cells inhibiting only certain populations depending on the TLR agonist . Positive_regulation TNF TLR6 18806225 1969752 *induced* [TNF] and IL-1 production are normal in macrophages derived from spin mice . Positive_regulation TNF TLR6 19322177 2064450 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ) , but not [TNF] , in *response* to ligands . Positive_regulation TNF TLR6 19428561 2077080 The aim of this study was to determine whether stimulation of toll-like receptor 2 (TLR2) , TLR4 , and by their specific ligands *induces* the production of [tumor necrosis factor-alpha (TNF-alpha)] in fibroblast-like synoviocytes ( FLS ) from interleukin-1 receptor antagonist ( IL-1Ra ) -deficient mice . Positive_regulation TNF TLR6 19428561 2077083 Stimulation of TLR2 , TLR4 , and by their specific ligands *increased* the production of [TNF-alpha] in FLS from IL-1Ra-deficient mice . Positive_regulation TNF TLR6 19428561 2077084 These data show that TLR2 , TLR4 , and ligation synergistically *stimulates* the production of [TNF-alpha] and IL-1beta in IL-1Ra-deficient mice and suggest that TLRs contribute to the perpetuation of spontaneous arthritis in this animal model . Positive_regulation TNF TLR6 19454685 2084532 activation *induces* [TNF-alpha] production from adult neural stem/progenitor cells . Positive_regulation TNF TLR6 19890037 2165883 MAPKs are crucial for [TNF-alpha] and IL-6 production by innate immune cells in *response* to ligands . Positive_regulation TNF TLR6 20148136 2208409 Although [TNFalpha] secretion by adipose cells is probably *induced* , most notably by ligands , the activation and secretion pathways of this cytokine are not yet entirely understood . Positive_regulation TNF TLR6 20337718 2273180 WNV infection or agonist treatment of gammadelta T cells *induced* the production of IFN-gamma , [tumor necrosis factor-alpha] and IL-6 , which are known to promote DC maturation . Positive_regulation TNF TLR6 20542322 2284809 *induced* [TNF-alpha] and IFN-alpha production by PBMCs was impaired in the patient and his brother . Positive_regulation TNF TLR6 20588172 2285772 Responses by THP-1 cells to TLR stimulation were quantified using Quanti-Blue colometric assay , and *induced* [tumor necrosis factor-alpha] production of primary monocytes was quantified by intracellular cytokine staining using flow cytometry . Positive_regulation TNF TLR6 21968712 2617041 In this report , we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages , leading to incapability for the production of inflammatory cytokines like [tumor necrosis factor (TNF)-a] and interleukin (IL)-1ß in *response* to stimulation . Positive_regulation TNF TLR6 22042224 2540122 Activation of *leads* to activation of NF-?B and release of proinflammatory cytokines , such as IL-6 and [TNF-a] . Positive_regulation TNF TLR6 22116836 2529928 signals *increased* levels of interferon ( IFN ) ß and [tumor necrosis factor (TNF)] a transcripts in the brains of infected mice and both TNF-a and IFN-a/ß , receptors promoted T-cell and trypanosoma infiltration into the brain parenchyma . Positive_regulation TNF TLR6 22345668 2572021 Knockdown of hnRNP U expression greatly attenuated *induced* expression of [TNF-a] , IL-6 , and IL-1ß , but not IL-12 , whereas hnRNP U overexpression greatly increased TLR induced expression of TNF-a , IL-6 , and IL-1ß . Positive_regulation TNF TLR6 22440523 2600815 The expression of *induced* production of [TNF-a] , IFN-a , IL-6 , and IL-12 were measured by multicolor flow cytometry . Positive_regulation TNF TLR6 22986631 2720024 Further , we demonstrated that *induced* [tumor necrosis factor-a] and interferon-ß contributed to the differential phagocytosis of apoptotic neutrophils and bacteria by macrophages . Positive_regulation TNF TLR6 23264656 2732525 We found that [TNF] *induced* surface TLR2 expression and augmented induced cytokine production in P. gingivalis stimulated BMDM , establishing a previously unidentified TNF dependent feedback loop . Positive_regulation TNF TLR6 23504259 2809767 Adenosine signaling suppresses the *dependent* expression of [TNF-a] , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Positive_regulation TNF TLR6 24205068 2864719 We compared *induced* production of pro-interleukin (IL)-1ß , IL-6 , and [tumor necrosis factor (TNF)-a] between 2-month-old infants and adults . Positive_regulation TNF TLR6 24771857 2937071 At the cellular level , Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower [TNF-a] and higher IL-10 in *response* to ligands than did their WT counterparts . Positive_regulation TNF TLR7 11238656 790948 Together , these data suggest that Mtb induced [TNF-alpha] production is largely *dependent* on signaling . Positive_regulation TNF TLR7 12133979 967089 Moreover , various ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* NF-kappa B activation and up-regulated [TNF-alpha] production in osteoclast precursor cells . Positive_regulation TNF TLR7 15611271 1357360 Furthermore , different ligands *stimulated* IL-6 and [TNF-alpha] production via signaling pathways , which showed unique characteristics . Positive_regulation TNF TLR7 15949138 1421212 Differences between newborns and adults with respect to *induced* [TNF-alpha] release extend to a range of TLR agonists , including bacterial lipopeptides , and are due to differences in soluble factors present in blood plasma . Positive_regulation TNF TLR7 15994412 1446963 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for [tumor necrosis factor] ( TNF-alpha ) , interleukin 6 , nitric oxide synthase-II ( iNOS ) , and NADPH oxidase 2 (Nox2) . Positive_regulation TNF TLR7 16426002 1515707 Although a number of variables influence ligand *induced* [TNF] responses , this assay can be optimized for potential clinical use to screen patients with primary immunodeficiencies affecting TLR function . Positive_regulation TNF TLR7 16538507 1574464 binding *results* in cell signal transduction and subsequent production of various proinflammatory cytokines such as IL-1 and [TNF-alpha] . Positive_regulation TNF TLR7 16713974 1564995 We report that IFN-gamma augments *induction* of [TNFalpha] by ligands , immune complexes , and zymosan by suppressing IL-10 production and thereby interrupting Stat3 mediated feedback inhibition . Positive_regulation TNF TLR7 16887962 1596663 In wild-type macrophages , TREM-2 knockdown increased *induced* [TNF] production . Positive_regulation TNF TLR7 17467812 1737398 stimulation of RA-FLS also *induced* the production of IL-1beta and [TNF-alpha] to a lesser extent ; Positive_regulation TNF TLR7 17496895 1744436 Here we document a function for the TNF family member 4-1BB ligand (4-1BBL) in sustaining *induced* [TNF] production . Positive_regulation TNF TLR7 17523427 1746078 Observed changes in *dependent* [TNF-alpha] production can play important role in pathogenesis of CVID . Positive_regulation TNF TLR7 17652449 1793639 *induced* [TNF-alpha] , IL-1beta , and IL-10 production is mediated through MyD88 , whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta . Positive_regulation TNF TLR7 17907168 1812689 Moreover , we found that IFNgamma induced BAFF synthesis is inhibited by simultaneous *stimulation* with either ligands or [TNFalpha] . Positive_regulation TNF TLR7 18271077 1865814 Stimulation with TLR2 , TLR4 and ligands , as well as TLR3 ligand , *resulted* in significantly lower production of [TNF-alpha] , but neither IL-6 nor IL-12p70 , by DCs from XLA patients in comparison to normal controls . Positive_regulation TNF TLR7 18713972 1950762 A number of recent studies show that activation of CR3 on dendritic cells (DCs) suppresses *induced* [TNF-alpha] and IL-12 production and inhibits effective Ag presentation . Positive_regulation TNF TLR7 18713972 1950792 *induced* [TNF-alpha] and IL-12 production by bone marrow derived DCs occurs heterogeneously , with apoptotic cells inhibiting only certain populations depending on the TLR agonist . Positive_regulation TNF TLR7 18806225 1969748 *induced* [TNF] and IL-1 production are normal in macrophages derived from spin mice . Positive_regulation TNF TLR7 19251253 2045122 The effect of toll-like receptor (TLR) 7 ligand pretreatment on the production of [tumor necrosis factor (TNF)-alpha] in *response* to or TLR2 ligand was examined in order to establish a new TLR mediated tolerance . Positive_regulation TNF TLR7 19322177 2064446 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ) , but not [TNF] , in *response* to ligands . Positive_regulation TNF TLR7 19454685 2084528 activation *induces* [TNF-alpha] production from adult neural stem/progenitor cells . Positive_regulation TNF TLR7 19890037 2165879 MAPKs are crucial for [TNF-alpha] and IL-6 production by innate immune cells in *response* to ligands . Positive_regulation TNF TLR7 20148136 2208405 Although [TNFalpha] secretion by adipose cells is probably *induced* , most notably by ligands , the activation and secretion pathways of this cytokine are not yet entirely understood . Positive_regulation TNF TLR7 20337718 2273176 WNV infection or agonist treatment of gammadelta T cells *induced* the production of IFN-gamma , [tumor necrosis factor-alpha] and IL-6 , which are known to promote DC maturation . Positive_regulation TNF TLR7 20542322 2284805 *induced* [TNF-alpha] and IFN-alpha production by PBMCs was impaired in the patient and his brother . Positive_regulation TNF TLR7 20588172 2285768 Responses by THP-1 cells to TLR stimulation were quantified using Quanti-Blue colometric assay , and *induced* [tumor necrosis factor-alpha] production of primary monocytes was quantified by intracellular cytokine staining using flow cytometry . Positive_regulation TNF TLR7 21957307 2502641 By using small interfering RNA screening , we further demonstrated that , among the RIG-I-like receptors (RLRs) and Toll-like receptors ( TLRs ) , only TLR2 , TLR6 , , and TLR9 *contribute* to the NF-?B dependent secretion of [TNF] and the inflammasome dependent secretion of IL-1ß in response to vMyxM013-KO virus infection . Positive_regulation TNF TLR7 21968712 2617037 In this report , we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages , leading to incapability for the production of inflammatory cytokines like [tumor necrosis factor (TNF)-a] and interleukin (IL)-1ß in *response* to stimulation . Positive_regulation TNF TLR7 22042224 2540118 Activation of *leads* to activation of NF-?B and release of proinflammatory cytokines , such as IL-6 and [TNF-a] . Positive_regulation TNF TLR7 22116836 2529924 signals *increased* levels of interferon ( IFN ) ß and [tumor necrosis factor (TNF)] a transcripts in the brains of infected mice and both TNF-a and IFN-a/ß , receptors promoted T-cell and trypanosoma infiltration into the brain parenchyma . Positive_regulation TNF TLR7 22345668 2572017 Knockdown of hnRNP U expression greatly attenuated TLR induced expression of TNF-a , IL-6 , and IL-1ß , but not IL-12 , whereas hnRNP U overexpression greatly increased *induced* expression of [TNF-a] , IL-6 , and IL-1ß . Positive_regulation TNF TLR7 22440523 2600811 The expression of *induced* production of [TNF-a] , IFN-a , IL-6 , and IL-12 were measured by multicolor flow cytometry . Positive_regulation TNF TLR7 22685319 2675996 Interestingly , despite expression of TLR mRNA on Kupffer cells , ligation of TLR4 , , and TLR9 *resulted* in a weak induction of IL-10 , low or undetectable levels of IL-12p40 and [TNF] , and up-regulation of CD40 on the surface . Positive_regulation TNF TLR7 22734582 2670126 and TLR-9 *induced* IFN-a and [TNF-a] production by pDCs from subjects with SLE was decreased relative to that found in controls ( TLR-9/IFN-a , P < 0.0001 ; Positive_regulation TNF TLR7 22777843 2682024 Although RNA could also induce moderate *dependent* IL-23 and [tumor necrosis factor-alpha] ( TNF-a ) secretion , TLR7 and other endosomal TLRs were redundant for IL-23 or TNF-a induction by whole fungi . Positive_regulation TNF TLR7 22986631 2720020 Further , we demonstrated that *induced* [tumor necrosis factor-a] and interferon-ß contributed to the differential phagocytosis of apoptotic neutrophils and bacteria by macrophages . Positive_regulation TNF TLR7 23264656 2732521 We found that [TNF] *induced* surface TLR2 expression and augmented induced cytokine production in P. gingivalis stimulated BMDM , establishing a previously unidentified TNF dependent feedback loop . Positive_regulation TNF TLR7 23504259 2809763 Adenosine signaling suppresses the *dependent* expression of [TNF-a] , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Positive_regulation TNF TLR7 23843519 2816467 In cultured neurons , activation *induced* IL-6 and [TNF-a] expression through Myd88 . Positive_regulation TNF TLR7 23966630 2836159 Whereas TLR9 induced TNF-a secretion of bone marrow derived macrophages and conventional dendritic cells was equally inhibited by INH-ODN 2088 and G-modified INH-ODNs such as INH-ODN 24888 , *induced* [TNF-a] release and TLR7- and TLR9 induced IL-12p40 release were significantly more impaired by G-modified INH-ODNs . Positive_regulation TNF TLR7 24205068 2864715 We compared *induced* production of pro-interleukin (IL)-1ß , IL-6 , and [tumor necrosis factor (TNF)-a] between 2-month-old infants and adults . Positive_regulation TNF TLR7 24205068 2864744 There was no difference in *induced* production of [TNF-a] . Positive_regulation TNF TLR7 24771857 2937067 At the cellular level , Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower [TNF-a] and higher IL-10 in *response* to ligands than did their WT counterparts . Positive_regulation TNF TLR8 11238656 790949 Together , these data suggest that Mtb induced [TNF-alpha] production is largely *dependent* on signaling . Positive_regulation TNF TLR8 12133979 967090 Moreover , various ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* NF-kappa B activation and up-regulated [TNF-alpha] production in osteoclast precursor cells . Positive_regulation TNF TLR8 15611271 1357361 Furthermore , different ligands *stimulated* IL-6 and [TNF-alpha] production via signaling pathways , which showed unique characteristics . Positive_regulation TNF TLR8 15949138 1421213 Differences between newborns and adults with respect to *induced* [TNF-alpha] release extend to a range of TLR agonists , including bacterial lipopeptides , and are due to differences in soluble factors present in blood plasma . Positive_regulation TNF TLR8 15994412 1446964 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for [tumor necrosis factor] ( TNF-alpha ) , interleukin 6 , nitric oxide synthase-II ( iNOS ) , and NADPH oxidase 2 (Nox2) . Positive_regulation TNF TLR8 16426002 1515708 Although a number of variables influence ligand *induced* [TNF] responses , this assay can be optimized for potential clinical use to screen patients with primary immunodeficiencies affecting TLR function . Positive_regulation TNF TLR8 16538507 1574465 binding *results* in cell signal transduction and subsequent production of various proinflammatory cytokines such as IL-1 and [TNF-alpha] . Positive_regulation TNF TLR8 16713974 1564996 We report that IFN-gamma augments *induction* of [TNFalpha] by ligands , immune complexes , and zymosan by suppressing IL-10 production and thereby interrupting Stat3 mediated feedback inhibition . Positive_regulation TNF TLR8 16887962 1596664 In wild-type macrophages , TREM-2 knockdown increased *induced* [TNF] production . Positive_regulation TNF TLR8 17467812 1737399 stimulation of RA-FLS also *induced* the production of IL-1beta and [TNF-alpha] to a lesser extent ; Positive_regulation TNF TLR8 17496895 1744437 Here we document a function for the TNF family member 4-1BB ligand (4-1BBL) in sustaining *induced* [TNF] production . Positive_regulation TNF TLR8 17523427 1746079 Observed changes in *dependent* [TNF-alpha] production can play important role in pathogenesis of CVID . Positive_regulation TNF TLR8 17652449 1793640 *induced* [TNF-alpha] , IL-1beta , and IL-10 production is mediated through MyD88 , whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta . Positive_regulation TNF TLR8 17907168 1812690 Moreover , we found that IFNgamma induced BAFF synthesis is inhibited by simultaneous *stimulation* with either ligands or [TNFalpha] . Positive_regulation TNF TLR8 18713972 1950763 A number of recent studies show that activation of CR3 on dendritic cells (DCs) suppresses *induced* [TNF-alpha] and IL-12 production and inhibits effective Ag presentation . Positive_regulation TNF TLR8 18713972 1950793 *induced* [TNF-alpha] and IL-12 production by bone marrow derived DCs occurs heterogeneously , with apoptotic cells inhibiting only certain populations depending on the TLR agonist . Positive_regulation TNF TLR8 18806225 1969749 *induced* [TNF] and IL-1 production are normal in macrophages derived from spin mice . Positive_regulation TNF TLR8 19322177 2064447 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ) , but not [TNF] , in *response* to ligands . Positive_regulation TNF TLR8 19454685 2084529 activation *induces* [TNF-alpha] production from adult neural stem/progenitor cells . Positive_regulation TNF TLR8 19457574 2208690 It could be demonstrated that the [TNFalpha] release in monocytes resulting from aPL stimulation was exclusively *induced* by engagement . Positive_regulation TNF TLR8 19850743 2170170 *dependent* [TNF-(alpha)] overexpression in Fanconi anemia group C cells . Positive_regulation TNF TLR8 19890037 2165880 MAPKs are crucial for [TNF-alpha] and IL-6 production by innate immune cells in *response* to ligands . Positive_regulation TNF TLR8 20148136 2208406 Although [TNFalpha] secretion by adipose cells is probably *induced* , most notably by ligands , the activation and secretion pathways of this cytokine are not yet entirely understood . Positive_regulation TNF TLR8 20337718 2273177 WNV infection or agonist treatment of gammadelta T cells *induced* the production of IFN-gamma , [tumor necrosis factor-alpha] and IL-6 , which are known to promote DC maturation . Positive_regulation TNF TLR8 20542322 2284806 *induced* [TNF-alpha] and IFN-alpha production by PBMCs was impaired in the patient and his brother . Positive_regulation TNF TLR8 20588172 2285769 Responses by THP-1 cells to TLR stimulation were quantified using Quanti-Blue colometric assay , and *induced* [tumor necrosis factor-alpha] production of primary monocytes was quantified by intracellular cytokine staining using flow cytometry . Positive_regulation TNF TLR8 20946625 2343630 Lower protein levels of in monocytes from RSV infected infants , compared to healthy infants , negatively correlated with respiratory frequency and *resulted* in lower [TNF-a] synthesis upon a specific TLR8 stimulation . Positive_regulation TNF TLR8 21968712 2617038 In this report , we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages , leading to incapability for the production of inflammatory cytokines like [tumor necrosis factor (TNF)-a] and interleukin (IL)-1ß in *response* to stimulation . Positive_regulation TNF TLR8 22042224 2540119 Activation of *leads* to activation of NF-?B and release of proinflammatory cytokines , such as IL-6 and [TNF-a] . Positive_regulation TNF TLR8 22116836 2529925 signals *increased* levels of interferon ( IFN ) ß and [tumor necrosis factor (TNF)] a transcripts in the brains of infected mice and both TNF-a and IFN-a/ß , receptors promoted T-cell and trypanosoma infiltration into the brain parenchyma . Positive_regulation TNF TLR8 22345668 2572018 Knockdown of hnRNP U expression greatly attenuated *induced* expression of [TNF-a] , IL-6 , and IL-1ß , but not IL-12 , whereas hnRNP U overexpression greatly increased TLR induced expression of TNF-a , IL-6 , and IL-1ß . Positive_regulation TNF TLR8 22440523 2600812 The expression of *induced* production of [TNF-a] , IFN-a , IL-6 , and IL-12 were measured by multicolor flow cytometry . Positive_regulation TNF TLR8 22986631 2720021 Further , we demonstrated that *induced* [tumor necrosis factor-a] and interferon-ß contributed to the differential phagocytosis of apoptotic neutrophils and bacteria by macrophages . Positive_regulation TNF TLR8 23264656 2732522 We found that [TNF] *induced* surface TLR2 expression and augmented induced cytokine production in P. gingivalis stimulated BMDM , establishing a previously unidentified TNF dependent feedback loop . Positive_regulation TNF TLR8 23504259 2809764 Adenosine signaling suppresses the *dependent* expression of [TNF-a] , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Positive_regulation TNF TLR8 24205068 2864716 We compared *induced* production of pro-interleukin (IL)-1ß , IL-6 , and [tumor necrosis factor (TNF)-a] between 2-month-old infants and adults . Positive_regulation TNF TLR8 24205068 2864745 There was no difference in *induced* production of [TNF-a] . Positive_regulation TNF TLR8 24771857 2937068 At the cellular level , Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower [TNF-a] and higher IL-10 in *response* to ligands than did their WT counterparts . Positive_regulation TNF TLR9 11238656 790950 Together , these data suggest that Mtb induced [TNF-alpha] production is largely *dependent* on signaling . Positive_regulation TNF TLR9 12133979 967091 Moreover , various ligands ( e.g. , peptidoglycan , poly ( I:C ) dsRNA , LPS , and CpG motif of unmethylated DNA , which act as ligands for TLR2 , 3 , 4 , and 9 , respectively ) *induced* NF-kappa B activation and up-regulated [TNF-alpha] production in osteoclast precursor cells . Positive_regulation TNF TLR9 15485822 1347323 *regulates* [tumor necrosis factor-alpha] expression by different mechanisms . Positive_regulation TNF TLR9 15611271 1357362 Furthermore , different ligands *stimulated* IL-6 and [TNF-alpha] production via signaling pathways , which showed unique characteristics . Positive_regulation TNF TLR9 15949138 1421214 Differences between newborns and adults with respect to *induced* [TNF-alpha] release extend to a range of TLR agonists , including bacterial lipopeptides , and are due to differences in soluble factors present in blood plasma . Positive_regulation TNF TLR9 15994412 1446965 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for [tumor necrosis factor] ( TNF-alpha ) , interleukin 6 , nitric oxide synthase-II ( iNOS ) , and NADPH oxidase 2 (Nox2) . Positive_regulation TNF TLR9 16402377 1513177 Since both RANKL-RANK and interactions *result* in NF-kappaB activation , p38 and ERK phosphorylation , and [TNF-alpha] synthesis ( all implicated in osteoclastogenesis ) , we hypothesized that CpG-ODN ( but not RANKL ) in addition induces the synthesis of an anti-osteoclastogenic factor . Positive_regulation TNF TLR9 16426002 1515709 Although a number of variables influence ligand *induced* [TNF] responses , this assay can be optimized for potential clinical use to screen patients with primary immunodeficiencies affecting TLR function . Positive_regulation TNF TLR9 16538507 1574466 binding *results* in cell signal transduction and subsequent production of various proinflammatory cytokines such as IL-1 and [TNF-alpha] . Positive_regulation TNF TLR9 16713974 1564997 We report that IFN-gamma augments *induction* of [TNFalpha] by ligands , immune complexes , and zymosan by suppressing IL-10 production and thereby interrupting Stat3 mediated feedback inhibition . Positive_regulation TNF TLR9 16870179 1593105 Activation of *induces* matrix metalloproteinase-9 expression through Akt and [tumor necrosis factor-alpha] signaling . Positive_regulation TNF TLR9 16887962 1596665 In wild-type macrophages , TREM-2 knockdown increased *induced* [TNF] production . Positive_regulation TNF TLR9 17092567 1732088 Lack of IFN-alpha/betaR signaling also blocked production of IFN-gamma and [TNF-alpha] in *response* to activation . Positive_regulation TNF TLR9 17117477 1677349 CpG stimulated signaling *increased* [TNF-alpha] and IL-6 levels ; Positive_regulation TNF TLR9 17467812 1737400 stimulation of RA-FLS also *induced* the production of IL-1beta and [TNF-alpha] to a lesser extent ; Positive_regulation TNF TLR9 17496895 1744438 Here we document a function for the TNF family member 4-1BB ligand (4-1BBL) in sustaining *induced* [TNF] production . Positive_regulation TNF TLR9 17523427 1746080 Observed changes in *dependent* [TNF-alpha] production can play important role in pathogenesis of CVID . Positive_regulation TNF TLR9 17548579 1784238 in turn , extracellular HMGB1 accelerates the delivery of CpG-ODNs to its receptor , leading to a *dependent* augmentation of IL-6 , IL-12 , and [TNFalpha] secretion . Positive_regulation TNF TLR9 17652449 1793641 *induced* [TNF-alpha] , IL-1beta , and IL-10 production is mediated through MyD88 , whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta . Positive_regulation TNF TLR9 17907168 1812691 Moreover , we found that IFNgamma induced BAFF synthesis is inhibited by simultaneous *stimulation* with either ligands or [TNFalpha] . Positive_regulation TNF TLR9 18332133 1904716 IRF-5 is critical for TLR3- , TLR4- , and dependent *induction* of [TNFalpha] in CD11c ( + ) dendritic cells . Positive_regulation TNF TLR9 18713972 1950764 A number of recent studies show that activation of CR3 on dendritic cells (DCs) suppresses *induced* [TNF-alpha] and IL-12 production and inhibits effective Ag presentation . Positive_regulation TNF TLR9 18713972 1950794 *induced* [TNF-alpha] and IL-12 production by bone marrow derived DCs occurs heterogeneously , with apoptotic cells inhibiting only certain populations depending on the TLR agonist . Positive_regulation TNF TLR9 18806225 1969750 *induced* [TNF] and IL-1 production are normal in macrophages derived from spin mice . Positive_regulation TNF TLR9 19322177 2064448 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ) , but not [TNF] , in *response* to ligands . Positive_regulation TNF TLR9 19454685 2084530 activation *induces* [TNF-alpha] production from adult neural stem/progenitor cells . Positive_regulation TNF TLR9 19685493 2186206 TLR-7 and stimulation *induces* production of IL-6 and [TNFalpha] . Positive_regulation TNF TLR9 19890037 2165881 MAPKs are crucial for [TNF-alpha] and IL-6 production by innate immune cells in *response* to ligands . Positive_regulation TNF TLR9 20148136 2208407 Although [TNFalpha] secretion by adipose cells is probably *induced* , most notably by ligands , the activation and secretion pathways of this cytokine are not yet entirely understood . Positive_regulation TNF TLR9 20337718 2273178 WNV infection or agonist treatment of gammadelta T cells *induced* the production of IFN-gamma , [tumor necrosis factor-alpha] and IL-6 , which are known to promote DC maturation . Positive_regulation TNF TLR9 20483722 2269992 Recent studies have suggested that TLR9 signaling in early endosomes leads to IFN-alpha production by plasmacytoid dendritic cells ( pDCs ) , whereas signaling in late endosomes *induces* pDC maturation , IL-6 , and [TNF-alpha] secretion . Positive_regulation TNF TLR9 20542322 2284807 *induced* [TNF-alpha] and IFN-alpha production by PBMCs was impaired in the patient and his brother . Positive_regulation TNF TLR9 20588172 2285770 Responses by THP-1 cells to TLR stimulation were quantified using Quanti-Blue colometric assay , and *induced* [tumor necrosis factor-alpha] production of primary monocytes was quantified by intracellular cytokine staining using flow cytometry . Positive_regulation TNF TLR9 20980631 2348900 Stimulation of on primary B cells *led* to the production of IL-6 , [TNF-a] , and IgG , which was inhibited in cells infected with EBV . Positive_regulation TNF TLR9 21115691 2357907 We show that IL-1R type I (IL-1RI) is essential for *dependent* activation of [tumor necrosis factor] receptor associated factor 3 ( TRAF3 ) and for production of the antiinflammatory cytokines IL-10 and type I interferon ( IFN ) . Positive_regulation TNF TLR9 21949737 2487990 Synthetic PIM ( 1 ) isomer and PIM ( 2 ) mimetic potently inhibit [TNF] and IL-12 p40 expression *induced* by TLR2 or TLR4 pathways , but not by , in murine macrophages . Positive_regulation TNF TLR9 21957307 2502642 By using small interfering RNA screening , we further demonstrated that , among the RIG-I-like receptors (RLRs) and Toll-like receptors ( TLRs ) , only TLR2 , TLR6 , TLR7 , and *contribute* to the NF-?B dependent secretion of [TNF] and the inflammasome dependent secretion of IL-1ß in response to vMyxM013-KO virus infection . Positive_regulation TNF TLR9 21968712 2617039 In this report , we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages , leading to incapability for the production of inflammatory cytokines like [tumor necrosis factor (TNF)-a] and interleukin (IL)-1ß in *response* to stimulation . Positive_regulation TNF TLR9 22042224 2540120 Activation of *leads* to activation of NF-?B and release of proinflammatory cytokines , such as IL-6 and [TNF-a] . Positive_regulation TNF TLR9 22116836 2529926 signals *increased* levels of interferon ( IFN ) ß and [tumor necrosis factor (TNF)] a transcripts in the brains of infected mice and both TNF-a and IFN-a/ß , receptors promoted T-cell and trypanosoma infiltration into the brain parenchyma . Positive_regulation TNF TLR9 22345668 2572019 Knockdown of hnRNP U expression greatly attenuated TLR induced expression of TNF-a , IL-6 , and IL-1ß , but not IL-12 , whereas hnRNP U overexpression greatly increased *induced* expression of [TNF-a] , IL-6 , and IL-1ß . Positive_regulation TNF TLR9 22440523 2600813 The expression of *induced* production of [TNF-a] , IFN-a , IL-6 , and IL-12 were measured by multicolor flow cytometry . Positive_regulation TNF TLR9 22685319 2675997 Interestingly , despite expression of TLR mRNA on Kupffer cells , ligation of TLR4 , TLR7/8 , and *resulted* in a weak induction of IL-10 , low or undetectable levels of IL-12p40 and [TNF] , and up-regulation of CD40 on the surface . Positive_regulation TNF TLR9 22734582 2670127 TLR-7 and *induced* IFN-a and [TNF-a] production by pDCs from subjects with SLE was decreased relative to that found in controls ( TLR-9/IFN-a , P < 0.0001 ; Positive_regulation TNF TLR9 22986631 2720022 Further , we demonstrated that *induced* [tumor necrosis factor-a] and interferon-ß contributed to the differential phagocytosis of apoptotic neutrophils and bacteria by macrophages . Positive_regulation TNF TLR9 23264656 2732523 We found that [TNF] *induced* surface TLR2 expression and augmented induced cytokine production in P. gingivalis stimulated BMDM , establishing a previously unidentified TNF dependent feedback loop . Positive_regulation TNF TLR9 23504259 2809765 Adenosine signaling suppresses the *dependent* expression of [TNF-a] , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Positive_regulation TNF TLR9 23724117 2793251 *induced* IFNA1 secretion as well as TLR4 induced [TNF] secretion from PBMCs was dose-dependently attenuated by coincubation with epinephrine . Positive_regulation TNF TLR9 23966630 2836160 Whereas *induced* [TNF-a] secretion of bone marrow derived macrophages and conventional dendritic cells was equally inhibited by INH-ODN 2088 and G-modified INH-ODNs such as INH-ODN 24888 , TLR7 induced TNF-a release and TLR7- and TLR9 induced IL-12p40 release were significantly more impaired by G-modified INH-ODNs . Positive_regulation TNF TLR9 24205068 2864717 We compared *induced* production of pro-interleukin (IL)-1ß , IL-6 , and [tumor necrosis factor (TNF)-a] between 2-month-old infants and adults . Positive_regulation TNF TLR9 24301797 2910663 CCK8 inhibited *induced* activation of [tumor-necrosis factor] receptor associated factor 6 , which is an important adapter protein in activation of interferon-regulatory factor (IRF)5 and IRF7 , possibly through CCK2R , by evoking the activity of protein kinase (PK)A and reducing the activity of PKC . Positive_regulation TNF TLR9 24771857 2937069 At the cellular level , Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower [TNF-a] and higher IL-10 in *response* to ligands than did their WT counterparts . Positive_regulation TNF TMA16 16796737 1605711 , on the contrary , dose-dependently *stimulated* the production of NO , [TNF] , and IL-6 by NR8383 cells and of NO and TNF , but not IL-6 , by primary AMs independent of sensitization . Positive_regulation TNF TMA7 16796737 1605712 , on the contrary , dose-dependently *stimulated* the production of NO , [TNF] , and IL-6 by NR8383 cells and of NO and TNF , but not IL-6 , by primary AMs independent of sensitization . Positive_regulation TNF TMC1 12400700 1009230 Lactobacillus acidophilus 0356 significantly *induced* the production of more IL-6 , IL-10 , IL-12 , and [TNF-alpha] than the other bacteria tested ( p < 0.0001 ; Positive_regulation TNF TMC2 12400700 1009231 Lactobacillus acidophilus 0356 significantly *induced* the production of more IL-6 , IL-10 , IL-12 , and [TNF-alpha] than the other bacteria tested ( p < 0.0001 ; Positive_regulation TNF TMC3 12400700 1009234 Lactobacillus acidophilus 0356 significantly *induced* the production of more IL-6 , IL-10 , IL-12 , and [TNF-alpha] than the other bacteria tested ( p < 0.0001 ; Positive_regulation TNF TMC4 12400700 1009235 Lactobacillus acidophilus 0356 significantly *induced* the production of more IL-6 , IL-10 , IL-12 , and [TNF-alpha] than the other bacteria tested ( p < 0.0001 ; Positive_regulation TNF TMC5 12400700 1009236 Lactobacillus acidophilus 0356 significantly *induced* the production of more IL-6 , IL-10 , IL-12 , and [TNF-alpha] than the other bacteria tested ( p < 0.0001 ; Positive_regulation TNF TMC6 12400700 1009232 Lactobacillus acidophilus 0356 significantly *induced* the production of more IL-6 , IL-10 , IL-12 , and [TNF-alpha] than the other bacteria tested ( p < 0.0001 ; Positive_regulation TNF TMC7 12400700 1009237 Lactobacillus acidophilus 0356 significantly *induced* the production of more IL-6 , IL-10 , IL-12 , and [TNF-alpha] than the other bacteria tested ( p < 0.0001 ; Positive_regulation TNF TMC8 12400700 1009233 Lactobacillus acidophilus 0356 significantly *induced* the production of more IL-6 , IL-10 , IL-12 , and [TNF-alpha] than the other bacteria tested ( p < 0.0001 ; Positive_regulation TNF TMC8 23429285 2744260 We show here that *induces* [TNF-a-] and TRAIL-dependant apoptosis . Positive_regulation TNF TMEFF1 23495748 2818671 We also demonstrated that and TR2 significantly *attenuated* the malondialdehyde ( MDA ) , nitric oxide ( NO ) , tumor necrosis factor ( [TNF-a] ) , and interleukin-1ß (IL-1ß) levels in either edema paw or serum at the fifth hour after Carr injection . Positive_regulation TNF TMEM11 12676602 1076808 Untreated and polymyxin B-pretreated .0 also *stimulated* more [TNF-alpha] production by RAW 264.7 cells than PM2.5-10 and PM1 .0-2.5 . Positive_regulation TNF TNC 15592496 1375244 [TNF-alpha] *induced* the expression of both and tenascin-C , and this induction was p38MAPK- and cyclooxygenase dependent . Positive_regulation TNF TNC 24241034 2916574 Importantly , autocrine and paracrine interactions of a9ß1 integrin and *induced* the expression of MMPs and IL-6 in synovial fibroblasts , as well as [TNF-a] and IL-1ß in synovial macrophages . Positive_regulation TNF TNFAIP1 1370465 179372 is encoded by a 3.5-kilobase transcript and is *induced* rapidly and transiently by [TNF] . Positive_regulation TNF TNFAIP3 17982095 1821049 The underlying mechanism of protection seems to involve a cascade of events , where [TNF] *induces* the expression of in hepatocytes , A20 down-modulates Bax expression by interference with transcriptional activation , and the reduced availability of Bax interferes with the onset of mitochondrial apoptosis and the ensuing apoptotic liver damage . Positive_regulation TNF TNFAIP3 19165919 2007036 The ( [tumor necrosis factor] alpha *induced* protein 3 ) gene encodes a ubiquitin editing enzyme , A20 , that restricts NF-kappaB dependent signaling and prevents inflammation . Positive_regulation TNF TNFAIP6 7935377 275802 [Tumor necrosis factor alpha (TNF-alpha)] and interleukin-1 (IL-1) *activate* transcription of the gene in normal human fibroblasts through a promoter region ( -165 to -58 ) that encompasses an AP-1 and a NF-IL6 site . Positive_regulation TNF TNFRSF10B 15502938 1342900 [Tumor necrosis factor (TNF)-R1] and expression levels had *increased* in liver tissues taken from the recipients . Positive_regulation TNF TNFRSF11A 16402377 1513175 Since both and CpG-ODN-TLR9 interactions *result* in NF-kappaB activation , p38 and ERK phosphorylation , and [TNF-alpha] synthesis ( all implicated in osteoclastogenesis ) , we hypothesized that CpG-ODN ( but not RANKL ) in addition induces the synthesis of an anti-osteoclastogenic factor . Positive_regulation TNF TNFRSF11B 14994384 1216185 [TNF-alpha] *induced* expression in all synovial fibroblasts , even OA and noninflammatory fibroblasts , and expression occurred to a remarkable degree in RA fibroblasts . Positive_regulation TNF TNFRSF11B 15479886 1319910 IL18 , IL1 beta , and [TNF alpha] did not *induce* M-CSF , GM-CSF , IFN gamma , or production in PHA prestimulated T cells or RA synovial T cells . Positive_regulation TNF TNFRSF11B 15642135 1363108 [TNF-alpha] *induced* IL-6 and production by synoviocytes , which was further increased with patient plasma dilutions and inhibited by infliximab . Positive_regulation TNF TNFRSF11B 17341304 1760089 The expression of and RANK by normal human blood neutrophils , however , can be *induced* by interleukin-4 + [tumor necrosis factor-alpha] and by SFs from patients with RA . Positive_regulation TNF TNFRSF11B 18083042 1854661 [TNF-alpha] *induced* apoptosis of SYM-1 cells within 24h and decreased OPG levels , while infliximab , a chimerical form of the anti-TNF-alpha antibody drug , suppressed the apoptosis and restored levels . Positive_regulation TNF TNFRSF12A 21893119 2506436 Conversely , activation of caspase by exogenous [TNF-a] *required* IL-13 , TWEAK , and . Positive_regulation TNF TNFRSF14 23495748 2818672 We also demonstrated that TR1 and significantly *attenuated* the malondialdehyde ( MDA ) , nitric oxide ( NO ) , tumor necrosis factor ( [TNF-a] ) , and interleukin-1ß (IL-1ß) levels in either edema paw or serum at the fifth hour after Carr injection . Positive_regulation TNF TNFRSF1A 10357816 618410 Here we demonstrate in different cellular systems that cytotoxic effects induced by TNF-R2 , CD40 and CD30 are mediated by endogenous production of [TNF] and autotropic or paratropic *activation* of . Positive_regulation TNF TNFRSF1A 10521481 653032 Engagement of *leads* to ATF-2- and p38 mitogen activated protein kinase dependent [TNF-alpha] gene expression . Positive_regulation TNF TNFRSF1A 11279049 819483 These data show that [TNF-alpha] decreases AQP5 mRNA and protein expression and that the molecular pathway for this effect *involves* and activated NF-kappaB . Positive_regulation TNF TNFRSF1A 11513085 849123 Preincubation with antibody against TNF receptor type 1 (TNFR1) or TNF receptor type 2 reduced the specific binding by 95 and 15 % , respectively , suggesting a dominating *role* of in 125I labeled [TNFalpha] ( 125I-TNFalpha ) binding . Positive_regulation TNF TNFRSF1A 11672546 872543 This [TNF] effect was *mediated* by TNFR2 ( p75 ) but not by ( p55 ) . Positive_regulation TNF TNFRSF1A 12011009 941368 We therefore suggest that *mediated* [TNF-alpha] signals might support a systemic humoral immune response against H. pylori and that the gastric inflammatory response to H. pylori infection seems to be independent of TNF-R1 mediated signals . Positive_regulation TNF TNFRSF1A 15182619 1255757 Antibody blocking test and RT-PCR were used to evaluate the role of ICAM-1 and VCAM-1 in the cytotoxicity of [TM-TNF-alpha] *mediated* by or TNFR II . Positive_regulation TNF TNFRSF1A 15670651 1365846 In contrast to TNF-alpha deficiency neither TNFR1 nor TNFR2 gene ablation showed protection against MPTP neurotoxicity , which argues for a protective mechanism of [TNF-alpha] not *mediated* by and TNFR2 signaling . Positive_regulation TNF TNFRSF1A 17030185 1630577 Transgenic TNFR2 , but not , expression *allowed* IFN-gamma independent [TNF] responses . Positive_regulation TNF TNFRSF1A 17223661 1765553 In early-passage RA/OA-SFB , activation of MAPK cascades and pro-inflammatory/pro-destructive features by [TNFalpha] is predominantly *mediated* by and , for proliferation and IL6/PGE ( 2 ) secretion , exclusively regulated by p38 . Positive_regulation TNF TNFRSF1A 17646260 1829644 *Activation* of or DR5 by [TNF-alpha] or TRAIL may regulate osteoblast connectivity , which is important to bone turnover . Positive_regulation TNF TNFRSF1A 18339717 1912470 To delineate the role of *mediated* [TNF-alpha] signaling in the pathogenesis of this disorder , a TNFR1 blocking peptide-Fc fusion protein ( TNFR1BP-Fc ) was used for the present study . Positive_regulation TNF TNFRSF1A 18397796 1893679 Moreover , EGCG inhibited Akt phosphorylation as well as [TNF] *activation* of , which subsequently resulted in reduced MCP-1 production . Positive_regulation TNF TNFRSF1A 18436580 1926406 [TNF] effects are *mediated* via two distinct membrane receptors : and TNFR2 . Positive_regulation TNF TNFRSF1A 18713739 1974756 We demonstrate that [TNF] *activation* of stimulates both pro- and anti-apoptotic signaling pathways in the colon epithelium ; Positive_regulation TNF TNFRSF1A 19112477 2004532 Different hypotheses pertain to the molecular and cellular effectors triggered by the *activation* of [TNF] receptors ( and TNFR2 ) . Positive_regulation TNF TNFRSF1A 19470832 2107470 We show that in skeletal muscle of cachectic patients there is 1 ) increased expression and activity of the TNF-alpha signaling , including [TNF-alpha] mRNA , *activation* of , and TNF-alpha associated to TNFR1 ; Positive_regulation TNF TNFRSF1A 20370892 2273374 However , the *role* of in mediating the [TNFalpha] effects in RA has not been elucidated and conflicting data exist in experimental arthritis models . Positive_regulation TNF TNFRSF1A 21191629 2425312 These results demonstrate that [TNF-a] increases expression and release of IL-6 by HUCs and that the effects of TNF-a are *mediated* by . Positive_regulation TNF TNFRSF1A 21709152 2455809 These results show that , not TNFR2 , *mediates* [TNF-a] stimulation of DC maturation and T cell response to mouse hepatitis virus in vivo . Positive_regulation TNF TNFRSF1A 22441986 2618104 [TNF-a] signals are *mediated* by two receptors : and TNF receptor 2 (TNFR2) . Positive_regulation TNF TNFRSF1A 23095497 2717255 The pro-inflammatory [TNF] effects were *mediated* by . Positive_regulation TNF TNFRSF1A 23869211 2817620 These data demonstrate that activation of intrinsic glomerular cells by soluble [TNF] *requires* , whereas TNFR2 is not essential , but augments TNFR1 dependent effects . Positive_regulation TNF TNFRSF1A 23903370 2887591 The effects of LPS on the glomerular endothelial surface layer , endothelial cell fenestrae , GFR , and albuminuria were diminished in TNF receptor 1 (TNFR1) knockout mice , suggesting that these LPS effects are mediated by [TNF-a] *activation* of . Positive_regulation TNF TNFRSF1A 8395024 228470 To investigate the *role* of in beneficial and detrimental activities of [TNF] , we generated TNFR1-deficient mice by gene targeting . Positive_regulation TNF TNFRSF1B 10531226 562075 Overall , these observations suggest that upregulation of or sTNF-RII *contributes* to modulation of the [TNF-alpha] antibacterial activity in MAC infections . Positive_regulation TNF TNFRSF1B 11672546 872544 This [TNF] effect was *mediated* by ( p75 ) but not by TNFR1 ( p55 ) . Positive_regulation TNF TNFRSF1B 11907088 923254 Here we demonstrate that CD40 induced [TNF] stimulates IgM production through CD120b and that signaling is *required* for optimal CD40 induced IgM secretion . Positive_regulation TNF TNFRSF1B 12296856 990979 Co-stimulation , but not the early inhibitory effect on , was IL-2 dependent and *led* to increased [TNF-alpha] production by both CD4+ and CD8+ T lymphocytes . Positive_regulation TNF TNFRSF1B 15182619 1255758 Antibody blocking test and RT-PCR were used to evaluate the role of ICAM-1 and VCAM-1 in the cytotoxicity of [TM-TNF-alpha] *mediated* by TNFR I or . Positive_regulation TNF TNFRSF1B 15242770 1270750 Autocrine [TNF-alpha] *acts* through receptors to stimulate proliferation . Positive_regulation TNF TNFRSF1B 15485859 1342611 Role of tumor necrosis factor (TNF) receptor associated factor 2 ( TRAF2 ) in distinct and overlapping CD40 and [TNF] receptor <2/CD120b> *mediated* B lymphocyte activation . Positive_regulation TNF TNFRSF1B 15670651 1365847 In contrast to TNF-alpha deficiency neither TNFR1 nor TNFR2 gene ablation showed protection against MPTP neurotoxicity , which argues for a protective mechanism of [TNF-alpha] not *mediated* by TNFR1 and signaling . Positive_regulation TNF TNFRSF1B 16195372 1462895 Wild-type [TNF] *induces* and Etk and activates both ASK1 and Etk but does not down-regulate TNFR1 . Positive_regulation TNF TNFRSF1B 17030185 1630578 Transgenic , but not TNFR1 , expression *allowed* IFN-gamma independent [TNF] responses . Positive_regulation TNF TNFRSF1B 17046178 1674724 In addition , [TNF-alpha] released from macrophages and TNF-receptor (TNFR) 1 and mRNA expression in lymphocytes were closely *involved* in this apoptosis induction . Positive_regulation TNF TNFRSF1B 17762182 1790181 TNFR1- mediated uptake of [TNF] was faster than *mediated* uptake of TNF . Positive_regulation TNF TNFRSF1B 17785864 1790838 4 ) ligation of mTNF on monocytes by surface transfected into resting T cells *induces* [TNF-alpha] production due to reverse signaling by mTNF ; Positive_regulation TNF TNFRSF1B 18436580 1926407 [TNF] effects are *mediated* via two distinct membrane receptors : TNFR1 and . Positive_regulation TNF TNFRSF1B 19112477 2004533 Different hypotheses pertain to the molecular and cellular effectors triggered by the *activation* of [TNF] receptors ( TNFRI and ) . Positive_regulation TNF TNFRSF1B 19541932 2099107 Since TRADD is not incorporated into *mediated* [TNFalpha] signaling , the persistent decrease in TRADD , associated with a mild decrease in TNFR1 levels , may function , at least in part , to divert TNFalpha signals toward a TNFR2 mediated pathway in UUO kidneys . Positive_regulation TNF TNFRSF1B 22441986 2618105 [TNF-a] signals are *mediated* by two receptors : TNF receptor 1 (TNFR1) and . Positive_regulation TNF TNFRSF1B 23711481 2827949 Full-length membrane bound [tumor necrosis factor-a] *acts* through to modify phenotype of sensory neurons . Positive_regulation TNF TNFRSF1B 8521496 336427 Intriguingly , *activation* of by membrane [TNF] can lead to qualitatively different TNF responses such as rendering resistant tumor cells sensitive to TNF mediated cytotoxicity . Positive_regulation TNF TNFRSF1B 8912006 395371 Using human TNF mutants with selective receptor binding properties it has been demonstrated in neutrophils and endothelium that is *involved* in the mediation of the proinflammatory activity of TNF by facilitating the p55 [TNF] receptor ( TNFR55 ) . Positive_regulation TNF TNFRSF21 11753679 890176 [Tumor necrosis factor-alpha] *induces* the expression of , a member of the TNF receptor family , through activation of NF-kappaB . Positive_regulation TNF TNFRSF4 15578092 1344759 We found that [TNF-alpha] *induced* expression on T cells and blocking the interaction between either CD40 and its ligand or OX40 and its ligand suppressed development of arthritis . Positive_regulation TNF TNFRSF4 18346319 1886682 The levels of IFNgamma and [TNFalpha] secreted by LP-CD(4) ( + ) T cells from the inflammatory colonic tissue were further *increased* by MoAb stimulation , but suppressed significantly by adding anti-OX40L MoAb ( compared with non stimulation , P < 0.01 , respectively ) . Positive_regulation TNF TNFRSF4 20181891 2229103 FACS analysis revealed that [TNF] also *induced* upregulation of cell surface expression of 4-1BB and specifically in CD45RA ( - ) FOXP3 ( + ) Tregs . Positive_regulation TNF TNFRSF4 9766631 538397 expression could be *induced* by interleukin-4 , but not by interferon-gamma or [tumor necrosis factor-alpha] . Positive_regulation TNF TNFRSF6B 15002040 1265069 Consistent with the abrogation of osteoclastogenic effect of DcR3 by TNFR-Fc , treatment can *induce* osteoclastogenic cytokine [TNF-alpha] release through ERK and p38 MAPK signaling pathways . Positive_regulation TNF TNFRSF8 7540942 310166 cross linking does not alter proliferation of ACH-2 cells and the induction of HIV expression is not *mediated* by endogenous [TNF alpha/beta] . Positive_regulation TNF TNFRSF8 7621881 315656 We have found that both the recombinant and CD40L *enhanced* interleukin (IL)-6 , [TNF] and lymphotoxin (LT)-alpha release from cultured H-RS cells . Positive_regulation TNF TNFRSF9 15886520 1406867 Cross linking of *increased* the secretion of IL-8 and [TNF-alpha] , promoted the expression of CD54 and CD11b , and increased adhesion to extracellular matrix (ECM) proteins . Positive_regulation TNF TNFRSF9 20008291 2191252 The expression of on activated human B cells is functionally relevant because engagement with its ligand at the time of activation stimulates B cell proliferation , enhances B cell survival , and *induces* secretion of [TNF-alpha] and -beta . Positive_regulation TNF TNFRSF9 20181891 2229104 FACS analysis revealed that [TNF] also *induced* upregulation of cell surface expression of <4-1BB> and OX40 specifically in CD45RA ( - ) FOXP3 ( + ) Tregs . Positive_regulation TNF TNFRSF9 23557259 2777798 Inhibition of p38MAPK and signaling *reduce* dengue virus induced [TNF-a] secretion and apoptosis . Positive_regulation TNF TNFSF10 10521444 652800 Moreover , inhibition of NF-kappaB by IkappaBalpha sensitizes cells to [tumor necrosis factor-] but not *induced* apoptosis . Positive_regulation TNF TNFSF10 11557763 875280 We show that [tumor necrosis factor (TNF)] and phorbol 12-myristate 13-acetate ( PMA ) *induce* ( TRAIL ) in T cells . Positive_regulation TNF TNFSF10 16762619 1572174 Interferon-gamma and [TNF-alpha] potently *induced* in IEC . Positive_regulation TNF TNFSF10 17047073 1635882 Furthermore , we show that [TNFalpha] *induces* through a transcriptional mechanism . Positive_regulation TNF TNFSF10 17989734 1889133 However , when induction of NF-kappaB was inhibited with a kinase dead IKK2 mutant ( IKK2-KD ) , [TNF-] but not *induced* apoptosis was dramatically enhanced . Positive_regulation TNF TNFSF10 18838202 1988248 Thus , FLIPL and FLIPS exerted differential effects in myeloid leukemic cell lines in *response* to and [TNF-alpha] . Positive_regulation TNF TNFSF11 11500955 847162 increased the level of TNF-alpha mRNA and *induced* [TNF-alpha] release from osteoclast progenitors . Positive_regulation TNF TNFSF11 11856640 914383 In the *presence* of permissive levels of , [TNF-alpha] acts directly to stimulate osteoclast differentiation of macrophages and myeloid progenitor cells . Positive_regulation TNF TNFSF11 15020327 1221533 In animal studies , [TNF] potently increases osteoclast formation in the *presence* of . Positive_regulation TNF TNFSF11 15020327 1221538 [TNFalpha] potently increased osteoclast proliferation/differentiation in the *presence* of . Positive_regulation TNF TNFSF11 16391513 1494350 In addition , *increased* the expression of [TNFalpha] , MCP-1 , and IL-6 but not of IL-10 , IL-12 , IFN-gamma , and iNOS . Positive_regulation TNF TNFSF11 16402377 1513176 Since both and CpG-ODN-TLR9 interactions *result* in NF-kappaB activation , p38 and ERK phosphorylation , and [TNF-alpha] synthesis ( all implicated in osteoclastogenesis ) , we hypothesized that CpG-ODN ( but not RANKL ) in addition induces the synthesis of an anti-osteoclastogenic factor . Positive_regulation TNF TNFSF11 16702601 1589856 RANKL induced osteoclastogenesis in these monocytic cells , and CLA inhibited *induced* [tumor necrosis factor-alpha] production and osteoclast differentiation , including osteoclast-specific genes such as tartrate-resistant acid phosphatase , cathepsin K , calcitonin receptor , and matrix metalloproteinase-9 expression and osteoclast-specific transcription factors such as c-Fos , nuclear factor of activated T-cells expression , and bone resorption pit formation . Positive_regulation TNF TNFSF11 17467668 1737368 *stimulated* [TNFalpha] production in osteoclast precursor cells promotes osteoclastogenesis by modulating RANK signaling pathways . Positive_regulation TNF TNFSF11 17467668 1737369 Furthermore , [TNFalpha] production in pOCs was *stimulated* by . Positive_regulation TNF TNFSF11 17467668 1737370 These results indicate that [TNFalpha] is *induced* by in pOCs and serves as an autocrine factor promoting osteoclastogenesis through c-Fos and NFATc1 activation . Positive_regulation TNF TNFSF11 18786965 1976019 On the other hand , [TNF-alpha] and IL-17 did not *induce* expression , although TNF-alpha , IL-17 or IL-1beta stimulated cell growth and IL-6 production . Positive_regulation TNF TNFSF11 18834246 1971243 Salivary levels of [TNF-alpha] were *detected* in all subjects , whereas levels of ICTP and were detected in only a minority of subjects . Positive_regulation TNF TNFSF11 19718038 2133596 Irf8-/- osteoclast precursors underwent increased osteoclastogenesis in *response* to and [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF TNFSF11 20890027 2326897 Especially , the increased production of IL-1 , IL-6 and [TNF-a] could *induce* the expression of in bone tissues to enhance osteoclastogenesis . Positive_regulation TNF TNFSF11 22298642 2570875 *stimulated* expression of [TNF-a] , IL-1a , and IL-1ß in neonatal rat cardiomyocytes via activation of NF-?B . Positive_regulation TNF TNFSF11 23123663 2729281 Coumermycin A1 also abrogated *induced* expression of interleukin-1ß , [tumor necrosis factor-a] , and inducible nitric oxide synthase in mouse BMMs . Positive_regulation TNF TNFSF11 24324641 2880278 In addition , mediated *increases* in the expression of c-Fos and nuclear factor of activated T-cells , cytoplasmic 1 ( NFATc1 ) and in the production of [tumor necrosis factor-a] , interleukin (IL)-1ß , and IL-6 were apparently inhibited by acteoside pretreatment . Positive_regulation TNF TNFSF11 24853804 2945367 Western blot analysis showed that LMW-HA reduced the *induced* expression of [tumor necrosis factor] receptor associated factor 6 ( TRAF6 ) , gelsolin and c-Src-proline-rich tyrosine kinase 2 suggesting that it could inhibit actin ring formation of osteoclast cells . Positive_regulation TNF TNFSF12 21211655 2374519 *upregulates* [TNF-a] expression in primary keratinocytes , whereas TNF-a did not affect the expression of TWEAK and its receptors . Positive_regulation TNF TNFSF12 21893119 2506424 Conversely , activation of caspase by exogenous [TNF-a] *required* IL-13 , , and Fn14 . Positive_regulation TNF TNFSF12 23469193 2750322 *promoted* [TNF-a] production in cultured THP-1 macrophages . Positive_regulation TNF TNFSF13B 15358625 1359069 We show that CXCL1/GROalpha , CXCL8/IL-8 , C5a , immune complexes , [tumor necrosis factor-alpha (TNF-alpha)] , leukotriene B4 , N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) , and lipopolysaccharide (LPS) , which by themselves do not *induce* de novo synthesis , act as potent secretagogues for BLyS , which is mainly stored in Golgi related compartments within G-CSF treated neutrophils , as determined by immunogold electron microscopy . Positive_regulation TNF TNFSF13B 17907168 1812670 In contrast to IFNgamma , neither [TNFalpha] , LPS , BLP , nor CpG *induced* the de novo synthesis and release of by FLS . Positive_regulation TNF TNFSF15 19786547 2147703 In vitro , *augmented* [TNF-alpha] production by T cells upon TCR ligation , and it greatly enhanced Th17 differentiation and IL-17 production . Positive_regulation TNF TNFSF15 24416448 2901139 *induces* TCR independent IL-6 and [TNF-a] production and growth of PLZF? leukocytes . Positive_regulation TNF TNFSF4 12798307 1098741 These studies demonstrate that ( a) OX40L plays a role in sustaining the long-term proliferation of CD8 ( + ) T cells in addition to the known effect on CD4 ( + ) T cells following activation , ( b ) *enhances* the production of Th1 cytokines ( IL-2 , IFN-gamma , and [TNF-alpha] ) from both CD4 ( + ) and CD8 ( + ) while no change in IL-4 expression was observed , and ( c ) the anti-apoptotic effect of OX40L on T cells is likely the result of sustained expression of anti-apoptotic genes while genes involved in apoptosis are inhibited . Positive_regulation TNF TNFSF9 17496895 1744430 Cell surface <4-1BBL> mediates sequential signaling pathways ` downstream ' of TLR and is *required* for sustained [TNF] production in macrophages . Positive_regulation TNF TNIP3 18081698 1882959 This revealed that the LPS- and [TNF-inducible] expression of ABIN-3 is *dependent* on the binding of NF-kappaB to a specific B site in the promoter . Positive_regulation TNF TNP1 15784689 1410065 Here , we demonstrated that inhibition of inhibitor of kappaB (IkappaB) kinase ( IKK ) by a peptide IKK inhibitor or by four individual chemical IKK inhibitors including 15-deoxy-prostaglandin J ( 2 ) , BMS-345541 , SC-514 , or sulindac significantly blocked IgE + *induced* [TNF] production by mouse bone marrow derived MC ( BMMC ) . Positive_regulation TNF TNP2 15784689 1410066 Here , we demonstrated that inhibition of inhibitor of kappaB (IkappaB) kinase ( IKK ) by a peptide IKK inhibitor or by four individual chemical IKK inhibitors including 15-deoxy-prostaglandin J ( 2 ) , BMS-345541 , SC-514 , or sulindac significantly blocked IgE + *induced* [TNF] production by mouse bone marrow derived MC ( BMMC ) . Positive_regulation TNF TNPO1 10861785 705331 sICAM-1 and [TNF-alpha] *induce* with distinct kinetics in astrocytes and brain microvascular endothelial cells . Positive_regulation TNF TNPO1 16856209 1607193 Neutrophil recruitment in immunized mice depends on *inducing* the sequential release of MIP-1alpha , [TNF-alpha] and LTB ( 4 ) . Positive_regulation TNF TNS1 3131074 83443 Thus it appears that contains another cytotoxic molecule and that [TNF] itself may *act* indirectly in vivo , perhaps by activating an effector cell . Positive_regulation TNF TP53 10880954 709215 When the responses of the tumour suppressors p53 and RB were analysed , it was found that [TNF-alpha] and C8-ceramide *induced* increased expression of . Positive_regulation TNF TP53 11314015 806343 Interestingly , we found that injection of TNF readily induced IEC apoptosis and that radiation induced a *dependent* increase in the intestinal level of [TNF] . Positive_regulation TNF TP53 11865195 917922 Taken together , our findings suggest that [TNFalpha] *induces* calpeptin dependent , but calpain independent accumulation of protein as a necessary step leading to death in L929 cells . Positive_regulation TNF TP53 12036088 949090 [TNF] *increases* proapoptotic levels and caspase activities in fetal membranes . Positive_regulation TNF TP53 12392301 1007698 Since many tumors secrete growth factor ( s ) that inhibit apoptosis and support the growth of cancer cells , we wanted to know whether insulin would have an effect on antitumor and *inducing* activities of human [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF TP53 16978650 1633552 We hypothesized that [TNF-alpha] would *induce* IRF-1 and protein binding in pancreatic acinar cells and that PYY would attenuate the effect . Positive_regulation TNF TP53 17567906 1763214 Functionally , transiently overexpressed Zfra sequestered NF-kappaB ( p65 ) , WOX1 , and phospho-ERK ( extracellular signal activated kinase ) in the cytoplasm , and [TNF] or UV light could not effectively *induce* nuclear translocation of these proteins . Positive_regulation TNF TP53 17599062 1774549 We also demonstrate that [TNF-alpha] is upregulated in *response* to and p53 inducing genotoxic stress , in a CDIP dependent manner . Positive_regulation TNF TP53 23108402 2837678 Current knowledge states that in certain cell types , 5-FU induced stress is signaling through a *dependent* induction of [tumor necrosis factor-receptor] oligomerization required for death inducing signaling complex formation and caspase-8 activation . Positive_regulation TNF TP53 23628949 2784415 Role of *mediated* regulation of NF-?ß and [TNF-a] was elucidated by Western blot analysis . Positive_regulation TNF TP53 7629160 316646 Taken together these results suggest that Rb , , and Cip1 ( p21 ) proteins *mediate* [TNF-alpha] antimitogenic activity , and TNF-alpha induces growth arrest in the G1 phase in MCF-7 cells . Positive_regulation TNF TP53 7649977 319154 We have recently reported that the tumor suppressor gene product binds to a site within the Sp1 binding region of the HIV-1 LTR and *contributes* to the [TNF] induction of this promoter . Positive_regulation TNF TP53 7649977 319159 Importantly , [TNF] *induced* the association between and Sp1 in Jurkat T cells . Positive_regulation TNF TP53 7760842 308026 Mutation of this sequence inhibited transactivation and [tumor necrosis factor] *inducibility* of the human immunodeficiency virus type 1 long terminal repeat . Positive_regulation TNF TP53 8166195 254835 [Tumor necrosis factor-alpha] *induced* a significant up-regulation of messenger ribonucleic acid levels in ovarian cancer cells grown in nude mice and in vitro , whereas interleukin-6 did not . Positive_regulation TNF TP53 8166195 254837 [Tumor necrosis factor-alpha] *induced* up-regulation of tumor suppressor gene expression in epithelial ovarian cancer cell lines , together with the induction of cell death by apoptosis . Positive_regulation TNF TP53 9405367 469777 Taken together , the present findings show that the cytotoxic activity of [TNF] towards oncoprotein expressing cells *involves* and an impaired signaling for survival in such cells . Positive_regulation TNF TP53 9737981 531657 By reverse transcription-polymerase chain reaction , we demonstrated that [TNF-alpha] transiently *induces* the in U937 cells . Positive_regulation TNF TP53 9842892 552983 TNF induced enterocyte apoptosis in mice is mediated by the [TNF] receptor 1 and does not *require* . Positive_regulation TNF TPX2 12709443 1100442 Moreover , we show that RelB , p50 , and can associate in the same complex and that [TNF-alpha] but not LTbeta signaling *increases* the association of p100 with RelB/p50 dimers in the nucleus , leading to the specific inhibition of RelB DNA binding . Positive_regulation TNF TPX2 17675290 1794072 By electrophoretic mobility shift assay analyses , [TNF-alpha] and lipopolysaccharide *induce* strong p65/p50 and heterodimer binding to both NF-kappaB and TF-kappaB probes . Positive_regulation TNF TPX2 19770515 2147449 In contrast , [TNF] *induced* robust osteoclast formation in vivo in mice lacking RANKL or RANK when the mice also lacked NF-kappaB , and TNF-Tg mice lacking NF-kappaB p100 had more severe joint erosion and inflammation than did TNF-Tg littermates . Positive_regulation TNF TPX2 19770519 2147460 [TNF-alpha] *induced* a sustained accumulation of in osteoclast precursors , and TNF-alpha induced osteoclast formation was markedly increased in Nfkb2-/- mice . Positive_regulation TNF TPX2 7957928 278114 Synergistic activation of intercellular adhesion molecule 1 ( ICAM-1 ) by [TNF-alpha] and IFN-gamma is *mediated* by p65/p50 and and interferon-responsive factor Stat1 alpha ( p91 ) that can be activated by both IFN-gamma and IFN-alpha . Positive_regulation TNF TPX2 9529131 496488 The results demonstrate that LPS , IL-1beta , and [TNF-alpha] *induce* expression at mRNA and protein level while IFN-gamma , IL-3 and IL-4/IL-10 have no effect . Positive_regulation TNF TRADD 17588511 1764382 In a recent issue of Molecular Cell , Kim et al. ( 2007 ) reported on a novel [TNF] receptor 1 necrotic signaling complex *inducing* and RIP1 dependent recruitment and activation of the ROS generating Nox1 NADPH oxidase complex . Positive_regulation TNF TRADD 21421854 2416747 The adaptor protein is *essential* for [TNF-like] ligand 1A/death receptor 3 signaling . Positive_regulation TNF TRAF1 10544244 564075 Here we demonstrate that expression of is *induced* by [TNF] and the protein kinase C ( PKC ) activator PMA , but not by interleukin-1 (IL-1) . Positive_regulation TNF TRAF2 23998902 2862134 The E3 ubiquitin ligase TRAF2 plays a crucial role for TNF-a mediated signaling since NF-?B activation by [TNF-a] is at least partially *mediated* by . Positive_regulation TNF TRAF3 8892903 392254 Nevertheless , the simian EBV LMP1s retain most functions in common with EBV LMP1 , including the ability to induce NF-(kappa)B activity in human cells , to bind the tumor necrosis factor associated factor 3 ( ) in vitro , and to *induce* expression of [tumor necrosis factor-responsive] genes , such as ICAM1 , in human B lymphocytes . Positive_regulation TNF TRAF4 15743827 1379095 Thus , both p47phox phosphorylation and are *required* for acute [TNF-alpha] signaling . Positive_regulation TNF TRAF6 10920205 722515 IL-1 , but not [tumor necrosis factor] , *induces* complex formation in a ligand dependent manner . Positive_regulation TNF TRAF6 15898987 1408680 These findings indicate that the production of [TNF-alpha] and IL-13 by LPS *required* signalling as a common pathway of mast cell mediated inflammation . Positive_regulation TNF TRAF6 17055451 1636506 While TNF-alpha exerts various biological effects including cell death , the *role* of in the [TNF-alpha] signaling remains to be unclear . Positive_regulation TNF TRAF6 23918981 2830765 In bone marrow derived macrophages ( BMDMs ) , the interaction was *required* for the late ( 2-8 h ) but not the early phase ( 0-2 h ) of il6 and [tnfa] mRNA production , and hence for IL-6 and TNF-a secretion by TLR agonists that signal via MyD88 . Positive_regulation TNF TREM1 10799849 691329 Engagement of *triggers* secretion of IL-8 , monocyte chemotactic protein-1 , and [TNF-alpha] and induces neutrophil degranulation . Positive_regulation TNF TREM1 12646648 1070228 Engagement of in combination with microbial ligands that activate Toll-like receptors also synergistically *increased* production of the proinflammatory cytokines [TNF-alpha] and GM-CSF , while inhibiting production of IL-10 , an anti-inflammatory cytokine . Positive_regulation TNF TREM1 17202378 1681036 Activation of expressed on PGE ( 2 ) -pretreated PBMC by an agonistic TREM-1 mAb significantly *enhanced* the production of IL-8 and [TNF-alpha] . Positive_regulation TNF TREM1 19721344 2133728 Activation of expressed on PGE ( 2 ) -pretreated peripheral blood mononuclear cells by an agonistic TREM-1 mAb significantly *enhanced* the production of [TNFalpha] . Positive_regulation TNF TREM1 21549750 2440458 Functionally , canine synergistically *enhances* LPS induced production of IL-8 , [TNF-a] and a canine orthologue of CXCL1 . Positive_regulation TNF TREM1 21659545 2459613 Importantly , *induced* production of the pro-inflammatory cytokines , [TNF-a] and IL-8 , and up-regulation of activation/differentiation cell surface markers were impaired in Btk knockdown cells . Positive_regulation TNF TRH 7895918 289879 Further [TNF] activation was *enhanced* by . Positive_regulation TNF TRIM8 23152791 2699825 [TNF] *induces* translocation of from nucleus to cytoplasm , which positively regulates NF-?B . Positive_regulation TNF TRNAI1 24766550 2956073 The level of cytokines [interleukin-6 ( IL-6 ) and [tumour necrosis factor-a (TNF-a)] ] and chemokines ( CXCL1 and CCL2 ) was *increased* by MDP , but not in wild-type ( WT ) neutrophils . Positive_regulation TNF TROVE2 11046070 742866 and anti-SSB/La autoantibodies bind the surface of apoptotic fetal cardiocytes and *promote* secretion of [TNF-alpha] by macrophages . Positive_regulation TNF TRPC1 12855710 1141614 [Tumor necrosis factor-alpha] *induces* nuclear factor-kappaB dependent expression in endothelial cells . Positive_regulation TNF TRPC1 12855710 1141620 Thus , [TNF-alpha] *induces* expression through an NF-kappaB dependent pathway in endothelial cells , which can trigger augmented Ca2+ entry following Ca2+ store depletion . Positive_regulation TNF TRPC1 17085428 1643707 Further , evidence suggests that the inflammatory cytokine [tumor necrosis factor-alpha] can *induce* the expression of in human vascular endothelial cells signaling via the nuclear factor-kappaB pathway . Positive_regulation TNF TRPC3 20360250 2255228 [TNFalpha] also *induced* expression and TRPC3 mediated constitutive cation influx and currents . Positive_regulation TNF TRPM2 20107186 2213069 By using short hairpin RNA to downregulate TRPM2 expression in THP-1 monocytes , we demonstrate that is *required* for the LPS induced production of IL-6 , IL-8 , IL-10 , and [TNF-alpha] . Positive_regulation TNF TRPV1 19695100 2139065 [TNF-alpha] *increases* ( 8 hr peak ) and TRPV4 ( 12 hr peak ) immunostaining , mRNA and protein expression , with a TRPV1 shift to membrane fractions . Positive_regulation TNF TRPV4 19695100 2139066 [TNF-alpha] *increases* TRPV1 ( 8 hr peak ) and ( 12 hr peak ) immunostaining , mRNA and protein expression , with a TRPV1 shift to membrane fractions . Positive_regulation TNF TSC22D3 20496421 2319887 Depleting expression in vivo increased the clinical and histologic severity of CIA and *increased* synovial expression of [tumor necrosis factor] and interleukin-1 (IL-1) , without affecting the levels of circulating cytokines or anticollagen antibodies . Positive_regulation TNF TSC22D3 23729444 2801846 Experiments in a human microvascular endothelial cell line demonstrated that [TNF-inducible] NF-?B activity was significantly *inhibited* by overexpression of . Positive_regulation TNF TSHR 19897675 2188823 They express at high levels and TSH *induces* fibrocytes to produce IL-6 and [TNF-alpha] . Positive_regulation TNF TSLP 21148792 2396230 Interestingly , [TNF-a] *induced* the promoter activity ( P < 0.05 ; n = 4 ) in HASM that was mediated by upstream NF-?B and activator protein-1 (AP-1) binding sites . Positive_regulation TNF TSN 21232147 2386718 also enhanced Akt and GSK-3ß phosphorylation and inhibited NF-?B phosphorylation , *resulting* in decreased [TNF-a] , IL-6 and MPO activities . Positive_regulation TNF TSPAN31 9343751 459043 also *induced* the release of [TNF-alpha] and IL-1 beta by human monocytes . Positive_regulation TNF TTC1 9085232 421466 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC12 9085232 421475 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC13 9085232 421486 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC14 9085232 421476 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC16 9085232 421487 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC17 9085232 421479 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC18 9085232 421491 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC19 9085232 421483 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC22 9085232 421484 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC23 9085232 421480 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC24 9085232 421492 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC25 9085232 421478 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC26 9085232 421473 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC27 9085232 421482 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC28 9085232 421488 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC29 9085232 421489 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC3 9085232 421467 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC31 9085232 421481 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC32 9085232 421493 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC33 9085232 421490 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC34 9085232 421495 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC36 9085232 421494 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC37 9085232 421474 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC38 9085232 421485 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC4 9085232 421468 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC40 9085232 421477 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC5 9085232 421469 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC6 9085232 421470 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC8 9085232 421471 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TTC9 9085232 421472 Western blotting of monocyte cytoplasmic membranes for membrane bound TNF alpha show that *causes* the retention of membrane associated [TNF alpha] on monocyte membranes , thereby preventing the release of TNF alpha into the culture media . Positive_regulation TNF TUFM 12543078 1028720 Here we focused on the *induced* [TNF] production and determined its responsible signal pathway . Positive_regulation TNF TUFM 12543078 1028721 The *induced* [TNF] production was mediated by the activation of MAPK family members , ERK and p38 MAPK , and by IkappaB degradation leading to the activation of NFkappaB . Positive_regulation TNF TUFM 12543078 1028722 The inhibitors for protein kinase C ( PKC ) and phospholipase C (PLC) prevented the *induced* [TNF] production . Positive_regulation TNF TUFM 12543078 1028736 Together , the *induced* [TNF] production was controlled by NFkB , p38 MAPK , and ERK that is dependent on the activities of PLC and PKC . Positive_regulation TNF TUFM 15681823 1366515 In skin wound regions from mice , [tumor necrosis factor-alpha] *induced* expression and secretion from macrophages recruited to the site . Positive_regulation TNF TXN 10666220 665442 We found that added to B-CLL cells *increased* in a dose dependent fashion the release of [TNF-alpha] , which has been suggested to be an autocrine growth factor for these cells . Positive_regulation TNF TXN 10666220 665443 In conclusion , we have found that human recombinant *induced* [TNF-alpha] secretion , maintained Bcl-2 , and reduced apoptosis in B-CLL cells . Positive_regulation TNF TXNIP 15696199 1382729 In cultured ECs , reduction of expression by small interfering RNA increased TRX binding to ASK1 and *inhibited* [TNF] activation of JNK/p38 and VCAM1 expression . Positive_regulation TNF TXNRD1 14584040 1187129 In the present study , we found that among these isozymes only was *induced* by [tumor necrosis factor-alpha (TNF alpha)] in vascular endothelial cells . Positive_regulation TNF TYK2 11801527 902545 Here we present evidence that [TNF-alpha] *induces* the activation of the cytoplasmic Janus tyrosine kinases Jak1 and in both human healthy peripheral and lymphoma B cells . Positive_regulation TNF TYK2 9510175 491844 In this study , we show that murine [TNF] *induces* the tyrosine phosphorylation and activation of the intracellular Janus tyrosine kinases Jak1 , Jak2 , and in murine 3T3-L1 adipocytes . Positive_regulation TNF UBC 19854138 2155763 We further show that IKK activation by [TNFalpha] *requires* , which functions with the E3 cIAP1 to catalyze polyubiquitination of RIP1 not restricted to K63 of ubiquitin . Positive_regulation TNF UBD 20433827 2282485 [TNFa] and IFNg treatment of HCC cell line Hepa 1-6 , *induced* the expression of and the expression of genes coding for the immunoproteasome ( LMP2 , LMP7 , and MECL-1 subunits ) . Positive_regulation TNF UBD 20433827 2282488 [TNFa] and IFNg *induced* the activity of the promoter , using a luciferase assay . Positive_regulation TNF UBE2N 19854138 2155752 We demonstrate that K63 of ubiquitin and the catalytic activity of , an E2 that catalyzes K63 polyubiquitination , are *required* for IKK activation by IL-1beta , but surprisingly , not by [TNFalpha] . Positive_regulation TNF UCHL1 8766549 374983 In contrast , neither mAb 10G10 , which recognizes an epitope distinct from the one recognized by mAb 4B2 , nor mAb , a CD45RO-specific antibody , induced any significant *increase* in [TNF-alpha] transcription . Positive_regulation TNF UCN2 21454316 2463645 When added to cultured endometrial cell cultures , significantly *increased* [TNF-a] ( P < 0.01 ) and IL-4 ( P < 0.001 ) , while Ucn 3 induced an increase of IL-4 secretion ( P < 0.01 ) . Positive_regulation TNF UCN2 22000474 2513133 *increased* the mRNA expression and secretion of IL-10 and [TNF-a] , and Ucn3 increased the mRNA expression and secretion of IL-10 , but did not modify the secretion of TNF-a . Positive_regulation TNF UCN2 22000474 2513138 *potentiated* the LPS induced increase of [TNF-a] expression and release , an effect reversed by astressin 2b . Positive_regulation TNF UCN2 22000474 2513140 The present study showed that and Ucn3 differentially *regulate* the LPS induced [TNF-a] and IL-10 expression and secretion in trophoblast explants acting through CRH-R2 . Positive_regulation TNF UCN3 22000474 2513132 Ucn2 increased the mRNA expression and secretion of IL-10 and [TNF-a] , and *increased* the mRNA expression and secretion of IL-10 , but did not modify the secretion of TNF-a . Positive_regulation TNF UCN3 22000474 2513139 The present study showed that Ucn2 and differentially *regulate* the LPS induced [TNF-a] and IL-10 expression and secretion in trophoblast explants acting through CRH-R2 . Positive_regulation TNF UCP1 10969838 728507 [Tumor necrosis factor (TNF)-alpha] and mRNA levels *increased* 12- and 6-fold , respectively , in isolated adipocytes from CLA fed mice compared with control mice . Positive_regulation TNF UGCG 11007940 735635 [TNF-alpha] also *induces* the activation of NF-kappa B and AP-1 and the subsequent increase in heavy subunit transcription in these cells . Positive_regulation TNF UGCG 14871291 1208142 The [TNF-driven] induction of SAA1 , but not that of SAA2 , can be *enhanced* by in both cell lines , whereas GCs alone can upregulate SAA1 only in epithelial cells . Positive_regulation TNF UMOD 11329451 808115 lethal toxicity in galactosamine sensitized mice , mitogenicity in mouse spleen cells , *induction* of [tumor necrosis factor alpha (TNF-alpha)] release from mouse peritoneal macrophages and J774-1 mouse macrophage-like and human line cells , nitric oxide induction activity from J774-1 cells , and Limulus gelation activity . Positive_regulation TNF UMOD 9120306 423858 and Tamm-Horsfall protein *induce* human monocytes to secrete [TNF] and express tissue factor . Positive_regulation TNF UMOD 9120306 423860 The release of URO and *induced* [TNF-alpha] in monocytes was dependent upon protein tyrosine kinase activation that results in tyrosine phosphorylation . Positive_regulation TNF UMOD 9890556 585470 The monocytic cell line can be *induced* to express and release [tumor necrosis factor alpha (TNFalpha)] and both TNFalpha receptors ( p55 and p75 ) upon exposure to bacterial lipopolysaccharide (LPS) . Positive_regulation TNF UQCRFS1 22730040 2639076 Moreover , Risp+ DM treatment attenuated *induced* plasma increases in [TNF-a] . Positive_regulation TNF USE1 7927791 273973 *induced* [TNF] activity and IL-6 expression were delayed compared with induction mediated by LPS . Positive_regulation TNF USF2 22342678 2576529 Furthermore , recombinant protein could selectively *enhance* the expression of interleukin (IL)-1a , IL-2 , IL-5 , IL-6 , [tumor necrosis factor-alpha] ( TNF-a ) , and lympotoxin ( LT ) in mouse spleen cells . Positive_regulation TNF USP11 19874889 2184471 In addition , overexpression of a catalytically inactive mutant partially *inhibits* [TNFalpha-] and IKKbeta induced NF-kappaB activation , suggesting that USP11 also exerts a non-catalytic function in its negative regulation of TNFalpha mediated NF-kappaB activation . Positive_regulation TNF USP21 19910467 2189300 inhibits [tumor necrosis factor] alpha *induced* nuclear factor kappaB activation via binding to and deubiquitinating receptor interacting protein 1 . Positive_regulation TNF USP48 16214042 1501144 Overexpression of in HEK 293T cells *inhibited* [TNFalpha] , CD40 , LMP1 , TRAF2 , TRAF6 and IKKbeta mediated NF-kappaB activation , but did not inhibit Smad mediated transcription activation . Positive_regulation TNF UTP15 15659223 1364818 and 2methylthioADP ( 2-MeSADP ) , P2Y receptor agonists , also *enhanced* this LPS induced [TNF-alpha] release . Positive_regulation TNF UTP15 19029040 2035153 [TNFalpha] induction of IL-8 secretion was also *increased* by ATPgammaS , , and UDP . Positive_regulation TNF UTP18 15659223 1364816 and 2methylthioADP ( 2-MeSADP ) , P2Y receptor agonists , also *enhanced* this LPS induced [TNF-alpha] release . Positive_regulation TNF UTP18 19029040 2035151 [TNFalpha] induction of IL-8 secretion was also *increased* by ATPgammaS , , and UDP . Positive_regulation TNF UTP20 15659223 1364814 and 2methylthioADP ( 2-MeSADP ) , P2Y receptor agonists , also *enhanced* this LPS induced [TNF-alpha] release . Positive_regulation TNF UTP20 19029040 2035149 [TNFalpha] induction of IL-8 secretion was also *increased* by ATPgammaS , , and UDP . Positive_regulation TNF UTP23 15659223 1364819 and 2methylthioADP ( 2-MeSADP ) , P2Y receptor agonists , also *enhanced* this LPS induced [TNF-alpha] release . Positive_regulation TNF UTP23 19029040 2035154 [TNFalpha] induction of IL-8 secretion was also *increased* by ATPgammaS , , and UDP . Positive_regulation TNF UTP3 15659223 1364817 and 2methylthioADP ( 2-MeSADP ) , P2Y receptor agonists , also *enhanced* this LPS induced [TNF-alpha] release . Positive_regulation TNF UTP3 19029040 2035152 [TNFalpha] induction of IL-8 secretion was also *increased* by ATPgammaS , , and UDP . Positive_regulation TNF UTP6 15659223 1364815 and 2methylthioADP ( 2-MeSADP ) , P2Y receptor agonists , also *enhanced* this LPS induced [TNF-alpha] release . Positive_regulation TNF UTP6 19029040 2035150 [TNFalpha] induction of IL-8 secretion was also *increased* by ATPgammaS , , and UDP . Positive_regulation TNF UTRN 21453958 2432619 Reduction of activity by mitochondrial division inhibitor and decrease of Drp1 expression using small interfering RNA *inhibit* mitochondrial translocation , degranulation , and [TNF] secretion . Positive_regulation TNF VAMP8 19564343 2104201 Furthermore , *regulates* the release of [TNF-alpha] and beta-hexosaminidase triggered by fMLP , and VAMP8 ( -/- ) mice are protected from fMLP induced peritonitis . Positive_regulation TNF VCAM1 10430178 633557 [Tumor necrosis factor-alpha (TNF-alpha)] *induced* both and ICAM-1 expression in human umbilical vein endothelial cells ( HUVECs ; Positive_regulation TNF VCAM1 10491002 645874 [TNF-alpha] and IL-1 sequentially *induce* endothelial ICAM-1 and expression in MRL/lpr lupus-prone mice . Positive_regulation TNF VCAM1 10807781 692329 [Tumor necrosis factor-alpha] *induced* the expression of , E-selectin , and ICAM-1 but had no effect on P-selectin expression . Positive_regulation TNF VCAM1 11678640 873678 [TNF-alpha] *induced* the expression of on HUVEC and GEC , but not MvE , while IFN-gamma induced VCAM-1 expression only on HUVEC . Positive_regulation TNF VCAM1 11961404 932606 NF-kappaB inhibitor , PDTC dose dependently inhibited the [TNF-alpha] *induced* mRNA expression . Positive_regulation TNF VCAM1 12124212 965693 Because IL-18 is a proinflammatory cytokine known to mediate the production of [TNF-alpha] and IL-1beta and to *induce* the expression of intercellular adhesion molecule-1 ( ICAM-1 ) and ( VCAM-1 ) , we hypothesized that neutralization of IL-18 would attenuate lipopolysaccharide (LPS) induced cardiac dysfunction . Positive_regulation TNF VCAM1 12587980 1029760 [TNFalpha] *induced* and ICAM-1 expression and Jurkat T cell binding . Positive_regulation TNF VCAM1 14984317 1214670 The effect of high glucose concentration on [TNF-alpha] *induced* expression of ELAM-1 , and ICAM-1 was negligible , if at all . Positive_regulation TNF VCAM1 15113938 1241387 [TNF-alpha] significantly *induced* HUVEC protein expression of , ICAM-1 , and E-selectin with increasing mRNA levels . Positive_regulation TNF VCAM1 15127201 1252060 Activation of the receptor for advanced glycation end products ( RAGE ) reportedly triggers cellular responses implicated in the pathogenesis of diabetes , such as increasing ( VCAM-1 ) expression on vascular endothelial cells and *inducing* [TNF-alpha] secretion by mononuclear cells . Positive_regulation TNF VCAM1 15625106 1362072 As in skin , [TNF] *induces* E-selectin and only on venular ECs , whereas intercellular adhesion molecule-1 is up-regulated on all human ECs . Positive_regulation TNF VCAM1 15696199 1382711 Normal flow inhibited [TNF] *activation* of JNK/p38 and expression . Positive_regulation TNF VCAM1 15696199 1382728 In cultured ECs , reduction of TXNIP expression by small interfering RNA increased TRX binding to ASK1 and inhibited [TNF] *activation* of JNK/p38 and expression . Positive_regulation TNF VCAM1 15812241 1392229 Realtime PCR studies showed that while [TNF alpha] potently *induced* gene expression , BE completely prevented it . Positive_regulation TNF VCAM1 15880045 1406194 [Tumor-necrosis factor-alpha] stimulation of PAEC-Gal-/- and PAEC-Gal+/+ *induced* an increase of CD62E and expression and increased cellular adhesion , in particular , of PMN . Positive_regulation TNF VCAM1 16317058 1518952 Lipopolysaccharide and [TNFalpha] *induced* and ICAM-1 mRNA and protein expression , as detected by real-time quantitative PCR , fluorescence activated cell sorting , and confocal microscopy , but this effect was inhibited when cells were incubated with DHT . Positive_regulation TNF VCAM1 16353157 1526371 We show that phenoxodiol inhibits hallmarks of endothelial cell activation , namely [TNF] or IL-1 *induced* E-selectin and expression and IL-8 secretion . Positive_regulation TNF VCAM1 17299025 1733428 Furthermore , blockade in ICAM-1-/- mice *suppressed* cutaneous [TNF-alpha] and IL-6 production . Positive_regulation TNF VCAM1 18227124 1895594 These findings revealed that [TNF-alpha] *induced* expression via multiple signaling pathways . Positive_regulation TNF VCAM1 18292233 1885517 In organ culture , [TNF] *induced* expression of E-selectin , , and ICAM-1 on HUVECs but only ICAM-1 on HUAECs . Positive_regulation TNF VCAM1 18656701 1942656 [TNF-alpha] could significantly *induce* CCL2 , ICAM-1 and expression of PTEC . Positive_regulation TNF VCAM1 20039412 2192616 Involvement of MAPKs and NF-kappaB in [tumor necrosis factor] alpha *induced* expression in human rheumatoid arthritis synovial fibroblasts . Positive_regulation TNF VCAM1 20069129 2177874 These results suggest that ticlopidine decreased [TNF-alpha] *induced* MCP-1 , IL-8 , and levels in HUVECs , and monocyte adhesion . Positive_regulation TNF VCAM1 22465119 2583187 Finally , [TNF-a] potently *induced* ICAM-1 and expression in both SV-EC and SV-SMC . Positive_regulation TNF VCAM1 7529998 291549 Here , we demonstrate that [TNF-alpha] and IL-1 beta transiently *induced* mRNA expression in a time dependent manner . Positive_regulation TNF VCAM1 7536438 297253 [TNF-alpha] *induced* endothelial E-selectin , intercellular adhesion molecule-1 ( ICAM-1 ) and ( VCAM-1 ) in all groups , and adhesion molecule expression by interstitial dermal dendritic cells ( ICAM-1 and VCAM-1 ) and keratinocytes ( ICAM-1 ) was observed . Positive_regulation TNF VCAM1 7693806 234207 However , [TNF-alpha] *induces* cell-surface expression and mRNA only in venous , but not in arterial EC . Positive_regulation TNF VCAM1 8194873 259003 [TNF alpha] *induced* increased expression of ELAM-I and adhesion molecules on intratumoral endothelial cells . Positive_regulation TNF VCAM1 8547644 346415 We have previously shown that expression is *induced* on human umbilical vein EC ( HUVEC ) by both [tumor necrosis factor alpha (TNF-alpha)] and interleukin-1 alpha (IL-1 alpha) , whereas on human dermal microvascular EC ( HDMEC ) only TNF alpha results in VCAM-1 expression . Positive_regulation TNF VCAM1 8568264 350969 [TNF] *induced* sustained expression within 4 h in lung , liver , and kidney . Positive_regulation TNF VCAM1 8792802 381015 IL-1 beta showed the strongest stimulatory effect on the expression of ICAM-1 , [TNF-alpha] preferentially *induced* the expression of and CD-44 , and Et-1 strongly stimulated the upregulation of CD-44 expression . Positive_regulation TNF VCAM1 8796130 381272 These results suggest that the monocyte-endothelial cell interaction *induces* the expression of ICAM-1 and in endothelial cells partially through the production of IL-1 and [TNF] . Positive_regulation TNF VCAM1 8861747 388552 THD is capable of changing the density of [tumor necrosis factor alpha (TNFalpha)] *induced* ICAM-1 ( CD54 ) , ( CD106 ) and E-selectin antigens on HUVEC . Positive_regulation TNF VCAM1 8863684 388849 [Tumor necrosis factor-alpha] *induced* a genistein-resistant up-regulation of . Positive_regulation TNF VCAM1 9072012 419851 was constitutively expressed by Bowman 's capsule and proximal tubules and was weakly *induced* on glomerular ECs by [TNF] and IL-4 in combination . Positive_regulation TNF VCAM1 9105426 423483 Role of tyrosine kinase enzymes in [TNF-alpha] and IL-1 *induced* expression of ICAM-1 and on human umbilical vein endothelial cells . Positive_regulation TNF VCAM1 9187938 437072 One of the well-known physiological substances that induce the PAI-1 gene is [tumor necrosis factor-alpha] , which also *induces* other possible risk factors of atherosclerosis , intercellular adhesion molecule-1 ( ICAM-1 ) and . Positive_regulation TNF VCAM1 9409229 471376 In cultured human smooth muscle cells from coronary arteries and saphenous veins , [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 beta (IL-1 beta) *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular cell adhesion molecule ( ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation TNF VCAM1 9537837 492365 Astroglioma cell lines as well as primary human fetal astrocytes expressed low levels of constitutively , and the proinflammatory cytokines *induced* marked increases in VCAM-1 expression , particularly [TNF-alpha] and IL-1beta . Positive_regulation TNF VCAM1 9663488 518377 Interleukin-1beta (IL-1beta) and [tumor necrosis factor alpha (TNFalpha)] further *induced* and ICAM-1 messenger RNA and protein expression . Positive_regulation TNF VCAM1 9825772 549216 expression on SK-N-SH was *induced* by IL-1alpha and [TNF alpha] and IFN gamma synergized with TNF alpha in this respect on both NB cell lines . Positive_regulation TNF VCAN 20012053 2374858 With respect to CD8+ T-cell responses , stimulation enhanced IFN-gamma expression in 44.4 % of AS patients and 39.4 % of controls , and *enhanced* [TNF-alpha] response in 50.0 % of AS patients and 39.4 % of controls ( P value 0.620 , 0.327 , respectively ) . Positive_regulation TNF VEGFA 12551841 1064174 Also as expected , [TNF-alpha] *induced* expression and secretion in a dose dependent manner . Positive_regulation TNF VEGFA 14517471 480036 Endothelial cells were stimulated with a growth factor [basic fibroblast growth factor ( bFGF ) and ( VEGF ) 165 ] and a cytokine [[tumor necrosis factor (TNF)-alpha] ] to *induce* the u-PA/u-PA receptor dependent formation of capillary-like tubular structures . Positive_regulation TNF VEGFA 14532277 1174884 Furthermore , [TNF-] but not *induced* activation of VEGFR2 , Akt , and EC migration are blunted in EC genetically deficient with Etk . Positive_regulation TNF VEGFA 14991903 1215652 Furthermore , *induced* IL-1beta , IL-6 , [TNF-alpha] , and nitric oxide expression to a small extent and stimulated the proliferation of immortalized chondrocytes . Positive_regulation TNF VEGFA 17202673 1681140 The CML adduct releases [TNF alpha] which might *induce* the production and release of for the abnormal choroidal neovascularization in the patients of age related macular degeneration . Positive_regulation TNF VEGFA 17216674 1681986 [Tumor necrosis factor-alpha] *induces* expression in rheumatoid synoviocytes . Positive_regulation TNF VEGFA 18639520 1947625 [TNF-alpha] and IL-1 *induced* secretion by corneal fibroblasts ( HCRF ) and this was inhibited significantly by IFN-gamma . Positive_regulation TNF VEGFA 18683887 2020120 [TNF-alpha] *induced* , resulting in neovascularization of disc tissues in a model of HD . Positive_regulation TNF VEGFA 18683887 2020126 Thus , [TNF-alpha] *induced* expression in disc cells primarily through the NF-kappaB pathway . Positive_regulation TNF VEGFA 19277666 2119963 In contrast , [TNF-alpha] did not *induce* production from RA-FLS and HUVEC . Positive_regulation TNF VEGFA 19744167 2147232 [TNF-alpha] and TLR-2 , -3 and -4 agonists *induced* the expression of , which was partially abolished by the blockage of HIF-1 alpha with CTM . Positive_regulation TNF VEGFA 22351621 2624260 We investigated the effects of low-level laser on the accumulation of HIF-1a , [tumor necrosis factor-a (TNF-a)] , and interleukin-1ß (IL-1ß) in controlling neuropathic pain , as well as on the *activation* of ( VEGF ) and nerve growth factor (NGF) in promoting functional recovery in a rat CCI model . Positive_regulation TNF VEGFA 23268960 2709650 Results showed that exogenous *upregulates* expression of interleukin (IL)-6 and [tumor necrosis factor (TNF)-a] mRNAs , whereas VEGF blocker partially diminishes the LPS induced expression of pro-inflammatory factors compared to the positive control group . Positive_regulation TNF VEGFA 23504259 2809762 Adenosine signaling suppresses the TLR dependent expression of [TNF-a] , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and *induces* the expression of vascular endothelial growth factor ( ) and IL-10 . Positive_regulation TNF VEGFA 8601593 351898 bFGF and enhanced of the u-PAR by 72 and 46 % , but [TNFalpha] itself also *increased* u-PAR in hMVEC by 30 % . Positive_regulation TNF VEGFA 9602864 506731 Conversely , UVA1R ( 5 and 7 J/cm2 ) did not modify the basal level of and did not *induce* the secretion of [TNF-alpha] by keratinocytes . Positive_regulation TNF VIP 10340296 616054 beta-endorphin effects glucose metabolism in the limbic system , CCK increases the release of beta-endorphin from the anterior pituitary , NPY is a powerful anxiolytic that regulates beta-endorphin and insulin , while indirectly *regulates* the expression of [TNF-alpha] through the inhibition of interleukin-4 (IL-4) . Positive_regulation TNF VIP 12225791 987849 *induced* the production of TGF-beta and [TNF-alpha] in BM mononuclear cells and stroma . Positive_regulation TNF VIP 7497530 335850 at all concentrations tested did not *induce* [TNF] production and was similar to untreated control cultures . Positive_regulation TNF VIP 8982099 403809 The [TNF alpha] production was *stimulated* by NPY and somatostatin in young subjects , and by NPY , somatostatin and in old ones , whereas GRP produced a decrease of TNF alpha in young persons . Positive_regulation TNF VPS13B 14573654 1155981 In a human whole-blood assay system , GBS type III potently *induced* substantial monocyte [TNF-alpha] release in adult peripheral blood and , due to a higher concentration of monocytes , 10-fold-greater TNF-alpha release in newborn cord blood . Positive_regulation TNF VTN 23619393 2790342 TGF-ß1 expression in microglia was *increased* by and to a lesser extent by [TNF-a] and LPS , but astrocyte TGF-ß1 expression was not regulated by any factor tested . Positive_regulation TNF VTN 8751898 377219 Since vitronectin contains a carbohydrate binding region , we postulated that binds fungal beta-glucans and subsequently *augments* macrophage [TNF-alpha] release in response to this fungal component . Positive_regulation TNF VWF 1509401 196521 [Tumor necrosis factor] *induces* release in healthy humans . Positive_regulation TNF VWF 1509401 196524 [TNF] *induced* a marked increase in antigen plasma levels , becoming significant after 45 min and peaking after 4 h ( percentage increase from base line : 351 +/- 46 ; p less than 0.0001 , TNF versus saline ) . Positive_regulation TNF WDR61 10422778 632389 However , exogenously added up to 100 nM did not *stimulate* production of [tumor necrosis factor-alpha] . Positive_regulation TNF WDR61 10435033 634212 [TNF-alpha] in the *presence* of WEB 2170 or CV 3988 , or was studied with the Greiss reagent method . Positive_regulation TNF WDR61 10921504 717355 antioxidants significantly inhibited both the in vivo and in vitro *induced* NF-kappaB activation and NF-kappaB dependent [TNF-alpha] expression . Positive_regulation TNF WDR61 15316260 1286193 The aim of this study was to determine [tumor necrosis factor alpha (TNF-alpha)] and interleukin-6 (IL-6) release in *response* to induction in peripheral blood mononuclear cells ( PBMCs ) from chronic hepatitis B virus ( HBV ) carriers . Positive_regulation TNF WDR61 15316260 1286213 Compared with group A , PBMCs from naturally immune subjects and chronic HBV carriers produced significantly higher amounts of [TNF-alpha] and IL-6 in *response* to . Positive_regulation TNF WDR61 15702351 1382761 Finally , up to 2 mug/ml , did not *induce* the production of pro-inflammatory cytokines such as IL-6 , IL-8 , and [TNF-alpha] . Positive_regulation TNF WDR61 1613396 191106 can *augment* [tumor necrosis factor (TNF)] production by human monocytes in a bimodal manner , with two peaks of activation at picomolar and micromolar concentrations . Positive_regulation TNF WDR61 1613396 191111 Moreover , 6 day- or 7 day differentiated HL-60 cells showed a further increase in [TNF] production in *response* to , and the response was bimodal , similar to that of the less dense subset of monocytes , with peaks at 10 ( -14 ) and 10 ( -7 ) M PAF . Positive_regulation TNF WDR61 1668105 176685 *induced* maximal [TNF alpha] synthesis 2-3 hr after monocyte stimulation as assessed by dot blotting of cell associated TNF alpha using polyclonal anti-TNF antibody . Positive_regulation TNF WDR61 16829183 1591447 Both [TNF-alpha] and IL-1beta induced HUVEC platelet activating factor (PAF) production and was *required* for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine ) . Positive_regulation TNF WDR61 17881124 1802340 The data indicate that these three biochemically unrelated classes of inflammatory repressors act synergistically in modulating *induced* up-regulation of COX-2 , [TNFalpha] , and PGE ( 2 ) by quenching oxidative stress or inflammatory signaling , resulting in increased HN cell survival . Positive_regulation TNF WDR61 1873355 165243 Further , the *role* of released in response to a challenge with LPS in the regulation of [TNF] and IL-6 production was investigated . Positive_regulation TNF WDR61 19769579 2258182 Our previous studies have demonstrated that UVB mediated production of keratinocyte [TNF-alpha] is in part *due* to . Positive_regulation TNF WDR61 20116443 2258832 An immediate low release of PGE ( 2 ) was *induced* by PAF , phorbol ester and arachidonic acid but not by IL1beta , [TNF-alpha] and LPS whereas a delayed high release of PGE ( 2 ) was induced by the inflammatory agents IL1beta , TNF-alpha and LPS but not by , phorbol ester and arachidonic acid . Positive_regulation TNF WDR61 20187806 2216116 However , did not *stimulate* the generation of IL-6 , IL-8 , [TNF-alpha] , and MMP-1 to any significant level and in a consistent manner . Positive_regulation TNF WDR61 20423922 2437234 In rats , [TNF-a] increased hydraulic conductivity 2.5-fold over baseline and *increased* it 5-fold ; Positive_regulation TNF WDR61 2133285 150726 Secretion of [TNF] was *detected* shortly after addition of and was dependent on the PAF concentration used . Positive_regulation TNF WDR61 2133285 150731 While biologically active and cytotoxic [TNF] was *detected* early after addition of , the cytotoxic activity declined thereafter though the antigenic activity remained constant . Positive_regulation TNF WDR61 2133286 150736 We have recently shown that can markedly *enhance* the production of [tumor necrosis factor (TNF)] and interleukin-1 (IL-1) by human monocytes stimulated with lipopolysaccharide or muramyl dipeptide ( MDP ) . Positive_regulation TNF WDR61 2230235 144610 The decrease in plasma [TNF alpha] *induced* by or alprazolam was partly reversed by indomethacin . Positive_regulation TNF WDR61 2266661 147297 Inhibitors of PAF synthesis , such as plasma alpha 1-proteinase inhibitor and an anti-inflammatory peptide , blocked changes induced by TNF , PAF receptor antagonists inhibited changes *induced* by and also by [TNF] . Positive_regulation TNF WDR61 2329280 132460 increased cell associated TNF maximally after 2 to 3 h of incubation and *increased* [TNF] release maximally after 5 to 18 h of incubation . Positive_regulation TNF WDR61 2545780 114297 *enhances* [tumor necrosis factor] production by alveolar macrophages . Positive_regulation TNF WDR61 2545780 114307 *Stimulation* of [TNF] production by was blocked by specific , but structurally different PAF receptor antagonists , BN 52021 , CV3988 and WEB 2086 . Positive_regulation TNF WDR61 2545780 114312 Inhibition of 5-lipoxygenase by nordihydro-guaiaretic acid or AA-861 blocked the *induced* augmentation of both [TNF] and LTB4 production . Positive_regulation TNF WDR61 2545780 114324 Collectively , these data suggest that *enhances* [TNF] production by interaction with a specific putative receptor and by subsequent induction of endogenous 5-lipoxygenase activity in AM . Positive_regulation TNF WDR61 7634340 317038 In addition , significantly *enhanced* LPS induced [TNF alpha] production . Positive_regulation TNF WDR61 7683748 216568 It has also been reported , that murine TNF stimulates the production of platelet activating factor (PAF) by cultured peritoneal macrophages , and that *enhances* [TNF] production by alveolar macrophages . Positive_regulation TNF WDR61 7821968 285550 We have shown previously that endotoxin , tumour necrosis factor (TNF) and platelet activating factor (PAF) are important in the pathogenesis of bowel injury , and that endotoxin and [TNF] *induce* formation in bowel tissue . Positive_regulation TNF WDR61 7895533 299759 also *caused* elevated serum [TNF-alpha] in some control mice but not in C3H/HeJ mice . Positive_regulation TNF WDR61 7930608 274731 Despite increasing RNA for the TNF-alpha gene , *increases* [TNF-alpha] protein levels only in the presence of a costimulus , such as PMA . Positive_regulation TNF WDR61 7930608 274736 We also report that *enhances* PMA induced [TNF-alpha] production from human peripheral B cells . Positive_regulation TNF WDR61 8045673 266907 ET-18-O-OCH3 and *stimulated* [TNF alpha] release by resident BALB/c macrophages in the presence of LPS but not in the absence of this co-factor . Positive_regulation TNF WDR61 8045673 266912 In contrast , both ET-18-O_OCH3 and *stimulated* [TNF alpha] release by thioglycollate elicited macrophages in the absence of LPS although release was greater in the presence of this co-stimulus . Positive_regulation TNF WDR61 8080039 270815 Interleukin-1 beta and [tumor necrosis factor-alpha] *induce* production by endothelium , and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist . Positive_regulation TNF WDR61 8088357 271461 Furthermore , [TNF] production *induced* by itself in vitro was also inhibited in the presence of FR128998 . Positive_regulation TNF WDR61 8514698 221953 Repeated dosing also *resulted* in sustained increased serum [tumor necrosis factor-alpha] levels ( 1,610 +/- 470 pg/ml , P < 0.01 ) and further exacerbation of the leukopenia ( -68 +/- 6 % , P < 0.01 ) and thrombocytopenia ( -65 +/- 8 % , P < 0.01 ) . Positive_regulation TNF WDR61 8704099 371132 We have assessed whether *stimulates* IL-6 and [TNF-alpha] production by human bone marrow stromal cells ( mostly fibroblast-like cells ) . Positive_regulation TNF WDR61 9249487 446830 and 2 ) endogenous [TNF-alpha] is not required for LPS mediated induction of iNOS mRNA , and *mediates* LPS induced APH . Positive_regulation TNF WDR61 9394802 468192 These data suggest that , which is released immediately or shortly after LPS injection , *induces* the expression of [TNF-alpha] through the activation of NF-kappa B . Positive_regulation TNF WISP1 19339243 2074327 Previously we demonstrated that is up-regulated in post-infarct heart , stimulates cardiac fibroblast proliferation , and is *induced* by the proinflammatory cytokine [tumor necrosis factor-alpha (TNF-alpha)] . Positive_regulation TNF WISP1 19339243 2074330 In CF , [TNF-alpha] potently *induced* expression in cyclic AMP response element binding protein ( CREB ) -dependent manner . Positive_regulation TNF WISP1 22700866 2676065 In peritoneal macrophages from strain matched mice , *augmented* LPS induced [TNF] release that was inhibited in macrophages from TLR4 or CD14 antigen gene targeted mice , and was attenuated in macrophages from myeloid differentiation primary response gene 88 gene targeted or TLR adaptor molecule 1 mutant mice . Positive_regulation TNF WNK1 10754326 682632 By transient transfection , NF-kappa B and p50 synergistically *activated* the [TNF-alpha] promoter . Positive_regulation TNF WNK1 12237295 1012362 We demonstrated that c-Jun , NFkappaB , p50 , and interact with and *activate* the [TNF-RE] by using mutational analysis of the TNF-RE , Tax mutants that selectively activate NFkappaB or the cAMP-response element binding protein/activating transcription factor pathway , and gel shift assays with nuclear extracts . Positive_regulation TNF WNK1 12716748 1083762 [TNF-alpha] *induced* inhibitor of kappaB ( IkappaB ) degradation and translocation from cytoplasm to nuclei in MIN6N8 insulinoma cells . Positive_regulation TNF WNK1 12859951 1111000 Electrophoretic mobility shift assays showed that [TNFalpha] *induced* binding to a potential NF-kappaB binding site at -460/-451 . Positive_regulation TNF WNK1 14514692 1164956 The [tumor necrosis factor] alpha dependent activation of the human mediterranean fever (MEFV) promoter is *mediated* by a synergistic interaction between C/EBP beta and NF kappaB . Positive_regulation TNF WNK1 15192014 1295262 Here we show that [TNF-alpha] *induces* greater ERK dependent phosphorylation at S536 in transformation sensitive ( P+ ) cells than in P- cells . Positive_regulation TNF WNK1 15980040 1465291 Overexpression of dominant negative *reduced* [TNF-alpha] production 3.5-fold , whereas overexpression of dominant negative IKK-beta reduced LPS induced TNF-alpha production 2-fold and p65 phosphorylation 2-fold . Positive_regulation TNF WNK1 16123045 1467029 [TNF-alpha] stimulation *induced* IKKbeta dependent nuclear translocation , mucus synthesis , and production of cytokines from epithelial cells . Positive_regulation TNF WNK1 16474009 1524013 Additionally , siRNA silencing of NF-kappaB also *prevented* the [TNF-alpha] increase in MLCK promoter activity . Positive_regulation TNF WNK1 17142966 1653794 [TNFalpha] stimulation *induced* the biphasic increases in expression of , ST3Gal I , FUT IV , ST3Gal IV and ST6GalNAc III mRNAs and the transient increase in expression of ST6Gal I mRNA and the decrease in ST3GalNAc IV mRNA . Positive_regulation TNF WNK1 17292554 1704704 LPS activated the NF-kappaB pathway , resulting in accumulation of NF-kappaB and p50 subunits in the nucleus and *activation* of [TNFalpha] promoter . Positive_regulation TNF WNK1 17675290 1794073 By electrophoretic mobility shift assay analyses , [TNF-alpha] and lipopolysaccharide *induce* strong p65/p50 and heterodimer binding to both NF-kappaB and TF-kappaB probes . Positive_regulation TNF WNK1 18235000 1864344 [TNF-alpha] *induced* the phosphorylation and downregulation of IkappaB-alpha and the translocation of the subunit of NF-kappaB to the nucleus . Positive_regulation TNF WNK1 18463678 1971655 Employing a series of in vitro and in cellulo approaches , we have demonstrated that in primary human keratinocytes ( i ) [TNF-alpha] rapidly *induces* ROS generation , IkappaB degradation , NF-kappaB nuclear translocation , and ultimately production of inflammatory cytokines ; Positive_regulation TNF WNK1 18566231 1929571 Pinitol also suppressed the NF-kappaB reporter activity *induced* by [tumor necrosis factor receptor (TNFR)-1] , TNFR associated death domain , TNFR associated factor-2 , transforming growth factor-beta activated kinase-1 ( TAK-1 ) /TAK1 binding protein-1 , and IkappaBalpha kinase but not that induced by . Positive_regulation TNF WNK1 18753141 1980023 Electrophoretic mobility shift showed that [tumor necrosis factor-alpha] *induced* binding to a potential NF-kappaB binding site at -460/-451 . Positive_regulation TNF WNK1 19151401 2079183 PolyI : C , flagellin , or [TNF-alpha] also *induced* NF-kappaB protein nuclear translocation . Positive_regulation TNF WNK1 19763702 2175969 High fat diet increased hepatic levels of SREBP-1c , TLR4 , [TNF-alpha] , and IL-6 protein and mRNA and increased *activation* of . Positive_regulation TNF WNK1 20663893 2317038 In the absence of PPAR? ligand , [TNF-a] *induced* a physical interaction between nuclear and PPAR? , as demonstrated by co-immunoprecipitation . Positive_regulation TNF WNK1 22213337 2617284 ( 3 ) resveratrol inhibited the *activation* of NF-?B by [TNF-a] or PMA in NCI-H292 cells ; Positive_regulation TNF WNK1 22275269 2658162 ( iii ) silibinin inhibited the *activation* of NF-?B by [TNF-a] in NCI-H292 cells ; Positive_regulation TNF WNK1 22653369 2625946 The production of [tumor necrosis factor-alpha] ( TNF-a ) , interleukin-10 (IL-10) , and NO and the *activation* of NF-?B were reduced by hypothermia , but augmented by hyperthermia at 3-6 , 24-48 , 48 , and 0.5 h , post-treatment initiation , respectively . Positive_regulation TNF WNK1 23603904 2795198 [Tumor necrosis factor a (TNFa)] *induced* rapid and complete sNix nucleoplasmic translocation concomitant with nuclear translocation of the subunit of NF?B . Positive_regulation TNF WNK1 7925300 273468 In HeLa cells as well as in B cells , [TNF-alpha] rapidly *induced* nuclear translocation primarily of , but not of c-rel . Positive_regulation TNF WNK1 7957928 278115 Synergistic activation of intercellular adhesion molecule 1 ( ICAM-1 ) by [TNF-alpha] and IFN-gamma is *mediated* by and p65/c-Rel and interferon-responsive factor Stat1 alpha ( p91 ) that can be activated by both IFN-gamma and IFN-alpha . Positive_regulation TNF WNK1 9718198 528179 These results suggest that the rapid activation of NF-kappaB by [TNF-alpha] is mainly due to the nuclear translocation of NF-kappaB pre existing in cytosol , and that the subsequent increase in the expression of p50 and may *result* in the persistent activation of NF-kappaB during TNF-alpha stimulation . Positive_regulation TNF WNT1 22879202 2682581 In particular , male-specific [TNF-alpha-NF-kB] signaling upon dioxin exposure and *activation* of the in boys upon acrylamide exposure might represent possible mechanistic explanations for gender specificity in the incidence of childhood leukemia . Positive_regulation TNF WNT1 23585476 2778483 signaling activation *stimulated* production of the proinflammatory cytokines IL-18 and [TNF-a] and regulated the NR2B glutamate receptor and Ca2+ dependent signals through the ß-catenin pathway in the spinal cord . Positive_regulation TNF WNT1 24286133 2877290 In addition , the activation of signaling by 6-bromoindirubin-3'-oxime ( BIO ) , which is a selective inhibitor of glycogen synthase kinase 3 (GSK-3) activity that activates Wnt signaling , *increased* [TNF-a] expression and promoter activity . Positive_regulation TNF WNT1 24286133 2877297 Here , we have demonstrated that signaling *regulates* [TNF-a] and that Wnt signaling and TNF-a form a positive-feedback loop in nucleus pulposus cells . Positive_regulation TNF WNT1 24286133 2877311 The results of the present study provide in vitro evidence that activation of signaling *upregulates* the [TNF-a] expression and might cause the degeneration of nucleus pulposus cells . Positive_regulation TNF WNT10A 11494032 846082 [Tumor necrosis factor alpha (TNFalpha)] *induced* up-regulation of in MKN45 cells . Positive_regulation TNF WNT10B 17568183 1815655 IL-6 and [TNFalpha] *induce* upregulation of WNT5A and , respectively . Positive_regulation TNF WNT11 22879202 2682582 In particular , male-specific [TNF-alpha-NF-kB] signaling upon dioxin exposure and *activation* of the in boys upon acrylamide exposure might represent possible mechanistic explanations for gender specificity in the incidence of childhood leukemia . Positive_regulation TNF WNT11 23585476 2778484 signaling activation *stimulated* production of the proinflammatory cytokines IL-18 and [TNF-a] and regulated the NR2B glutamate receptor and Ca2+ dependent signals through the ß-catenin pathway in the spinal cord . Positive_regulation TNF WNT11 24286133 2877291 In addition , the activation of signaling by 6-bromoindirubin-3'-oxime ( BIO ) , which is a selective inhibitor of glycogen synthase kinase 3 (GSK-3) activity that activates Wnt signaling , *increased* [TNF-a] expression and promoter activity . Positive_regulation TNF WNT11 24286133 2877298 Here , we have demonstrated that signaling *regulates* [TNF-a] and that Wnt signaling and TNF-a form a positive-feedback loop in nucleus pulposus cells . Positive_regulation TNF WNT11 24286133 2877312 The results of the present study provide in vitro evidence that activation of signaling *upregulates* the [TNF-a] expression and might cause the degeneration of nucleus pulposus cells . Positive_regulation TNF WNT16 22879202 2682587 In particular , male-specific [TNF-alpha-NF-kB] signaling upon dioxin exposure and *activation* of the in boys upon acrylamide exposure might represent possible mechanistic explanations for gender specificity in the incidence of childhood leukemia . Positive_regulation TNF WNT16 23585476 2778489 signaling activation *stimulated* production of the proinflammatory cytokines IL-18 and [TNF-a] and regulated the NR2B glutamate receptor and Ca2+ dependent signals through the ß-catenin pathway in the spinal cord . Positive_regulation TNF WNT16 24286133 2877296 In addition , the activation of signaling by 6-bromoindirubin-3'-oxime ( BIO ) , which is a selective inhibitor of glycogen synthase kinase 3 (GSK-3) activity that activates Wnt signaling , *increased* [TNF-a] expression and promoter activity . Positive_regulation TNF WNT16 24286133 2877303 Here , we have demonstrated that signaling *regulates* [TNF-a] and that Wnt signaling and TNF-a form a positive-feedback loop in nucleus pulposus cells . Positive_regulation TNF WNT16 24286133 2877317 The results of the present study provide in vitro evidence that activation of signaling *upregulates* the [TNF-a] expression and might cause the degeneration of nucleus pulposus cells . Positive_regulation TNF WNT2 22879202 2682583 In particular , male-specific [TNF-alpha-NF-kB] signaling upon dioxin exposure and *activation* of the in boys upon acrylamide exposure might represent possible mechanistic explanations for gender specificity in the incidence of childhood leukemia . Positive_regulation TNF WNT2 23585476 2778485 signaling activation *stimulated* production of the proinflammatory cytokines IL-18 and [TNF-a] and regulated the NR2B glutamate receptor and Ca2+ dependent signals through the ß-catenin pathway in the spinal cord . Positive_regulation TNF WNT2 24286133 2877292 In addition , the activation of signaling by 6-bromoindirubin-3'-oxime ( BIO ) , which is a selective inhibitor of glycogen synthase kinase 3 (GSK-3) activity that activates Wnt signaling , *increased* [TNF-a] expression and promoter activity . Positive_regulation TNF WNT2 24286133 2877299 Here , we have demonstrated that signaling *regulates* [TNF-a] and that Wnt signaling and TNF-a form a positive-feedback loop in nucleus pulposus cells . Positive_regulation TNF WNT2 24286133 2877313 The results of the present study provide in vitro evidence that activation of signaling *upregulates* the [TNF-a] expression and might cause the degeneration of nucleus pulposus cells . Positive_regulation TNF WNT2B 23785285 2802467 Here we show that secretion of and WNT9B and stabilization of ß-catenin ( CTNNB1 ) upon virus infection negatively *regulate* expression of representative inducible genes IFNB1 , IFIT1 and [TNF] in a CTNNB1 dependent effector mechanism . Positive_regulation TNF WNT3 22879202 2682584 In particular , male-specific [TNF-alpha-NF-kB] signaling upon dioxin exposure and *activation* of the in boys upon acrylamide exposure might represent possible mechanistic explanations for gender specificity in the incidence of childhood leukemia . Positive_regulation TNF WNT3 23585476 2778486 signaling activation *stimulated* production of the proinflammatory cytokines IL-18 and [TNF-a] and regulated the NR2B glutamate receptor and Ca2+ dependent signals through the ß-catenin pathway in the spinal cord . Positive_regulation TNF WNT3 24286133 2877293 In addition , the activation of signaling by 6-bromoindirubin-3'-oxime ( BIO ) , which is a selective inhibitor of glycogen synthase kinase 3 (GSK-3) activity that activates Wnt signaling , *increased* [TNF-a] expression and promoter activity . Positive_regulation TNF WNT3 24286133 2877300 Here , we have demonstrated that signaling *regulates* [TNF-a] and that Wnt signaling and TNF-a form a positive-feedback loop in nucleus pulposus cells . Positive_regulation TNF WNT3 24286133 2877314 The results of the present study provide in vitro evidence that activation of signaling *upregulates* the [TNF-a] expression and might cause the degeneration of nucleus pulposus cells . Positive_regulation TNF WNT4 22879202 2682585 In particular , male-specific [TNF-alpha-NF-kB] signaling upon dioxin exposure and *activation* of the in boys upon acrylamide exposure might represent possible mechanistic explanations for gender specificity in the incidence of childhood leukemia . Positive_regulation TNF WNT4 23585476 2778487 signaling activation *stimulated* production of the proinflammatory cytokines IL-18 and [TNF-a] and regulated the NR2B glutamate receptor and Ca2+ dependent signals through the ß-catenin pathway in the spinal cord . Positive_regulation TNF WNT4 24286133 2877294 In addition , the activation of signaling by 6-bromoindirubin-3'-oxime ( BIO ) , which is a selective inhibitor of glycogen synthase kinase 3 (GSK-3) activity that activates Wnt signaling , *increased* [TNF-a] expression and promoter activity . Positive_regulation TNF WNT4 24286133 2877301 Here , we have demonstrated that signaling *regulates* [TNF-a] and that Wnt signaling and TNF-a form a positive-feedback loop in nucleus pulposus cells . Positive_regulation TNF WNT4 24286133 2877315 The results of the present study provide in vitro evidence that activation of signaling *upregulates* the [TNF-a] expression and might cause the degeneration of nucleus pulposus cells . Positive_regulation TNF WNT5A 17568183 1815656 IL-6 and [TNFalpha] *induce* upregulation of and WNT10B , respectively . Positive_regulation TNF WNT5A 23539626 2782569 We show that inhibition of by specific antagonists *blocks* gp120 induced up-regulation of IL-1ß , IL-6 , and [TNF-a] in the spinal cord . Positive_regulation TNF WNT6 22879202 2682586 In particular , male-specific [TNF-alpha-NF-kB] signaling upon dioxin exposure and *activation* of the in boys upon acrylamide exposure might represent possible mechanistic explanations for gender specificity in the incidence of childhood leukemia . Positive_regulation TNF WNT6 23585476 2778488 signaling activation *stimulated* production of the proinflammatory cytokines IL-18 and [TNF-a] and regulated the NR2B glutamate receptor and Ca2+ dependent signals through the ß-catenin pathway in the spinal cord . Positive_regulation TNF WNT6 24286133 2877295 In addition , the activation of signaling by 6-bromoindirubin-3'-oxime ( BIO ) , which is a selective inhibitor of glycogen synthase kinase 3 (GSK-3) activity that activates Wnt signaling , *increased* [TNF-a] expression and promoter activity . Positive_regulation TNF WNT6 24286133 2877302 Here , we have demonstrated that signaling *regulates* [TNF-a] and that Wnt signaling and TNF-a form a positive-feedback loop in nucleus pulposus cells . Positive_regulation TNF WNT6 24286133 2877316 The results of the present study provide in vitro evidence that activation of signaling *upregulates* the [TNF-a] expression and might cause the degeneration of nucleus pulposus cells . Positive_regulation TNF WNT9B 23785285 2802466 Here we show that secretion of WNT2B and and stabilization of ß-catenin ( CTNNB1 ) upon virus infection negatively *regulate* expression of representative inducible genes IFNB1 , IFIT1 and [TNF] in a CTNNB1 dependent effector mechanism . Positive_regulation TNF WT1 23225417 2705707 The TCR transduced CD8 ( + ) T-cells produced interferon-? ( IFN? ) and [tumor necrosis factor-a (TNFa)] in *response* to stimulation not only with the modified WT1 ( 235 ) peptide but also with the natural ( 235 ) peptide and lysed modified or natural WT1 ( 235 ) peptide pulsed target cells and endogenously WT1 expressing leukemia cells in a HLA-A*24 : 02-restriction manner . Positive_regulation TNF WWOX 16219768 1489147 is *essential* for [tumor necrosis factor-] , UV light- , staurosporine- , and p53 mediated cell death , and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53 . Positive_regulation TNF XCL1 15817686 1397501 An additional stress induced increase in infiltration was observed for neutrophils , in response to TNF-alpha , macrophages , in response to [TNF-alpha] and LTN , and natural killer cells and T cells in *response* to . Positive_regulation TNF XDH 1544679 183450 Our results suggest that [TNF-alpha] injures brain microvascular EC and that this effect may be *mediated* by . Positive_regulation TNF XDH 16385082 1520075 These results suggest that myocardial I/R initiates expression of [TNF-alpha] , which *induces* activation of and production of O2*- , leading to coronary endothelial dysfunction . Positive_regulation TNF XDH 16413574 1520713 *Activation* of JNK and by [TNF-alpha] impairs nitric oxide mediated dilation of coronary arterioles . Positive_regulation TNF XIAP 11565837 863832 On the other hand , with cytotoxic drugs alone *induced* only a modest release of [TNFalpha] , which was not followed by an immediate rise in IL-6 and IL-8 . Positive_regulation TNF XIAP 16924232 1692185 [TNF] *induced* the expression of NF-kappaB regulated gene products cyclin D1 , c-Myc , matrix metalloproteinase-9 , survivin , ( IAP ) , IAP1 , Bcl-x ( L ) , A1/Bfl-1 and Fas associated death domain protein-like IL-1beta converting enzyme-inhibitory protein in wild-type MEF but not in PKR-/- cells . Positive_regulation TNF XIAP 17133355 1677743 In human endothelial cells , [TNF-alpha] *induced* c-IAP1 and c-IAP2 , but not and TIAP/Survivin , at the transcriptional level . Positive_regulation TNF XPO1 17064665 1649624 Inhibition of *dependent* cellular release of [TNFalpha] could thus provide a novel therapeutic approach for disorders involving excessive TNFalpha release . Positive_regulation TNF XRCC5 9636658 513387 The *role* of , a protein kinase involved in the response to DNA damage , in the activation of NF kappa B by IR and [TNF alpha] was examined . Positive_regulation TNF XRCC6 9636658 513388 The *role* of , a protein kinase involved in the response to DNA damage , in the activation of NF kappa B by IR and [TNF alpha] was examined . Positive_regulation TNF YME1L1 15618187 1357633 Freeze-thaw and cell lysis experiments , along with actinomycin D studies , suggested that CCL20 and [TNF-alpha] are synthesized in *response* to stimulation . Positive_regulation TNF YME1L1 15972514 1423983 To determine whether estradiol ( E2 ) modulates *induced* CCL20/MIP3alpha and [TNF-alpha] secretion , primary cultures of rat UEC were incubated with E2 for 24 h and then treated with LPS or Pam3Cys or not treated for an additional 12 h. E2 inhibited the constitutive secretion of TNF-alpha and CCL20/MIP3alpha into culture media . Positive_regulation TNF YME1L1 21075456 2371537 This study investigated the *induction* of IFN-a , IL-12 p40 , IL-1ß , [TNF-a] , IL-6 and IL-10 by [ CpG oligonucleotide D19 ( CpG ) , peptidoglycan ( PGN ) , lipopolysaccharide (LPS) , Pam ( 3 ) Cys and poly-U ] in porcine blood mononuclear cells ( BMC ) within a 24 h period . Positive_regulation TNF YY1 12972287 1139470 In addition , GATA , , and ISRE were shown to be specifically *activated* by PMA but not [TNFalpha] . Positive_regulation TNF ZFAND6 21810480 2484820 These data indicate that binds to tumor necrosis factor receptor associated factor 2 and that *regulates* [tumor necrosis factor] alpha induced nuclear factor kappaB activation through two distinct domains . Positive_regulation TNF ZFP36 10483872 643906 *stimulated* synthesis of IFN and [TNF] in the whole blood cultures . Positive_regulation TNF ZFP36 10763822 683931 expression is *induced* by [TNF-alpha] , and evidence indicates that TTP can bind and destabilize the TNF-alpha mRNA . Positive_regulation TNF ZFP36 11447117 835521 Moreover , IL-10 does not alter [TNF] mRNA stability , and its action does not *require* the presence of the stability regulating ARE binding factor , indicating a differential assembly of stability and translation determinants on the TNF ARE . Positive_regulation TNF ZFP36 17606294 1842191 *regulates* [TNF] TNF-alpha mRNA stability via a proteasome dependent mechanism involving the combined action of the ERK and p38 pathways . Positive_regulation TNF ZFP36 19106809 2093293 Confocal microscopy and real-time polymerase chain reaction showed that [TNF-alpha] *induced* intracellular expression . Positive_regulation TNF ZFP36 23288922 2763984 Overexpression of *suppressed* HQ-induced [TNF-a] upregulation and restored the viability of HQ-treated cells . Positive_regulation TNF ZFP36 23468959 2750179 *mediates* radiation induced [TNF-a] production in lung macrophages . Positive_regulation TNF ZFP36 24095726 2878796 Inhibition of HO-1 activity or HO-1 expression attenuated the effects of nicotine on STAT3 activation , *induction* , and [TNF-a] production in LPS treated macrophages . Positive_regulation TNF ZFP36 24095726 2878804 In an LPS induced endotoxemia model , HO-1 deficiency blocked the effects of nicotine on the STAT3 phosphorylation , *induction* , and LPS induced [TNF-a] production in the liver . Positive_regulation TNF ZFP36 7694559 234316 *induces* interferon and [tumor necrosis factor] production in human peripheral blood leukocytes . Positive_regulation TNF ZFP64 23857586 2829904 overexpression *promoted* TLR triggered [TNF-a] , IL-6 , and IFN-ß production in macrophages . Positive_regulation TNFAIP1 TNF 1370465 179373 [B12] is encoded by a 3.5-kilobase transcript and is *induced* rapidly and transiently by . Positive_regulation TNFAIP2 ERBB2 15609325 1369120 overexpression suppresses the transcription of antiangiogenic factors ( e.g. , Sparc , Timp3 , Serpinf1 ) but *induces* expression of angiogenic factors ( e.g. , Klf5 , [Tnfaip2] , Sema3c ) . Positive_regulation TNFAIP2 PDLIM7 23975427 2942266 Quantitative RT-PCR and western blotting revealed that *induces* [TNFAIP2] expression through its C-terminal activating region ( CTAR2 ) domain , which is required for transduction of NF-?B ( nuclear factor kappa-light-chain-enhancer of activated B cells ) signaling . Positive_regulation TNFAIP2 PDLIM7 23975427 2942268 Inhibition of NF-?B activation or depletion of p65 ( a component of NF-?B ) by RNA interference abolished the *induced* expression of [TNFAIP2] , whereas ectopic expression of p65 was sufficient to induce TNFAIP2 expression . Positive_regulation TNFAIP2 PDLIM7 23975427 2942269 Luciferase reporter assays showed that transcriptionally *induces* [TNFAIP2] expression through a newly identified NF-?B binding site within the TNFAIP2 promoter ( -3,869 to -3,860 bp ) . Positive_regulation TNFAIP2 TNF 1374453 186309 Nuclear run-on experiments demonstrate that *induction* of [B94] transcript occurs primarily at the level of transcriptional activation . Positive_regulation TNFAIP2 WNK1 23975427 2942267 Inhibition of NF-?B activation or depletion of p65 ( a component of NF-?B ) by RNA interference abolished the LMP1 induced expression of TNFAIP2 , whereas ectopic expression of was *sufficient* to induce [TNFAIP2] expression . Positive_regulation TNFAIP3 CD14 9763560 537136 Induction of A1 and [A20] does not require synthesis of intermediary proteins , but is *dependent* on the presence of soluble . Positive_regulation TNFAIP3 TNF 10849440 701180 We have identified the *induced* anti-apoptotic [A20] gene as a target gene of TAF(II)105 . Positive_regulation TNFAIP3 TNF 12080044 976098 In the this study , we demonstrated that PML is a transcriptional repressor of the A20 promoter and that PML represses [A20] expression *induced* by . Positive_regulation TNFAIP3 TNF 12431991 1037093 We find that regulation of the first transient phase is mediated by the degradation and subsequent resynthesis of IkappaBalpha , as well as by a *induced* expression of [A20] . Positive_regulation TNFAIP3 TNF 14614151 1165545 In accordance , the *induced* expression of NFkappaB target genes ( [A20] , IkappaBalpha ) in vascular smooth muscle cells was prolonged in cells isolated from C57BL/6J compared with FVB/N mice . Positive_regulation TNFAIP3 TNF 17982095 1821050 The underlying mechanism of protection seems to involve a cascade of events , where *induces* the expression of [A20] in hepatocytes , A20 down-modulates Bax expression by interference with transcriptional activation , and the reduced availability of Bax interferes with the onset of mitochondrial apoptosis and the ensuing apoptotic liver damage . Positive_regulation TNFAIP3 TNF 19826422 2154670 Impaired *induced* [A20] expression in E1A/Ras transformed cells . Positive_regulation TNFAIP3 TNF 21604024 2435925 *induced* protein 3 or [TNFAIP3] is involved in the negative feedback regulation of nuclear factor-?B ( NF-?B ) signaling in response to specific pro-inflammatory stimuli in different cell types . Positive_regulation TNFAIP3 TNF 23982206 2833049 TCR- or *induced* expression of other NF-?B target genes , such as NFKBIA ( which encodes I?Ba ) and [TNFAIP3] ( which encodes A20 ) , occurred independently of the O-GlcNAcylation of c-Rel . Positive_regulation TNFAIP3 TNF 8444879 213718 Transient transfection studies demonstrated that *stimulation* of [A20] transcription by , phorbol 12-myristate 13-acetate ( PMA ) , and Tax was mediated by two kappa B elements within the A20 promoter . Positive_regulation TNFAIP6 IL1B 16873769 1672474 In primary cultures of differentiated human airway epithelial and submucosal gland cells , [TSG-6] is *induced* by TNF-alpha and , which suggests that these cells are responsible for TSG-6 release in vivo . Positive_regulation TNFAIP6 TNF 11943733 928746 *stimulated* [TSG-6] mRNA accumulation in a dose- and time dependent manner , with the maximal response observed at 10 ng/ml after 6 hours of incubation . Positive_regulation TNFAIP6 TNF 15836955 1397789 Some of the hyaluronan binding factors that have been identified in the COC matrix are the serum derived factor inter-alpha trypsin inhibitor ( IalphaI ) and *stimulated* gene-6 ( [TSG-6] ) . Positive_regulation TNFAIP6 TNF 16873769 1672473 In primary cultures of differentiated human airway epithelial and submucosal gland cells , [TSG-6] is *induced* by and IL-1beta , which suggests that these cells are responsible for TSG-6 release in vivo . Positive_regulation TNFAIP6 TNF 21774025 2467219 A functional study of TNF demonstrated that depletion of endogenous TNF decreased oocyte competence and TNFAIP6 expression in cumulus cells , while in IVM medium *regulated* [TNFAIP6] expression in cumulus cells . Positive_regulation TNFAIP6 TNF 7516184 257474 [TSG-6] is a secreted 35-kDa glycoprotein , *inducible* by and IL-1 . Positive_regulation TNFAIP6 TNF 7876106 298309 We have previously shown that transcription factors of the NF-IL6 and AP-1 families cooperatively modulate *activation* of the [TSG-6] gene by or interleukin 1 (IL-1) through a promoter region that contains an NF-IL6 site ( -106 to -114 ) and an AP-1 element ( -126 to -119 ) . Positive_regulation TNFAIP6 TNF 7935377 275803 and interleukin-1 (IL-1) *activate* transcription of the [TSG-6] gene in normal human fibroblasts through a promoter region ( -165 to -58 ) that encompasses an AP-1 and a NF-IL6 site . Positive_regulation TNFAIP6 TNF 7935377 275807 Consistent with this possibility , IL-1 and markedly increase the binding of Fos and Jun to the AP-1 site , and NF-IL6 *activates* the native [TSG-6] promoter . Positive_regulation TNFAIP8 TNF 11346652 827748 The inhibition of NF-kappa B by I kappa B alpha , a natural inhibitor of NF-kappa B , suppressed [NDED] mRNA expression *induced* by . Positive_regulation TNFAIP8 TNF 19112178 2036843 Finally , our studies highlight a central role for COUP-TFI in the *induction* of the [TNFAIP8] promoter by . Positive_regulation TNFAIP8 TNF 23299407 2764042 *induced* protein 8 ( [TNFAIP8] ) is an anti apoptotic and pro-oncogenic signaling molecule involved in the process of immunity , carcinogenesis and tumor progression . Positive_regulation TNFAIP8 TNF 24577093 2920034 Tumor suppressor Tipe2 ( or *induced* protein 8 ( [TNFAIP8] ) -like 2 ( TNFAIP8L2 ) ) is a newly identified anti-inflammatory protein of the TNFAIP8 family that is essential for maintaining immune homeostasis . Positive_regulation TNFRSF10A EPHB2 19786087 2209050 Combined treatment with esculetin and HA14-1 upregulated the expression of [death receptor 4 (DR4)] , and *activation* of in a time dependent manner . Positive_regulation TNFRSF10A TNF 22301394 2570936 It was found that both CPT and *up-regulated* the expression of [TRAIL receptor 1/2] but not TRAIL in HaCaT cells . Positive_regulation TNFRSF10A TNF 22498762 2601793 Our results indicate that both curcumin and *up-regulated* the expression of [TRAIL-R1/R2] . Positive_regulation TNFRSF10A TNFSF10 11494138 846148 Differential *activation* of [TRAIL-R1] and -2 by soluble and membrane allows selective surface antigen directed activation of TRAIL-R2 by a soluble TRAIL derivative . Positive_regulation TNFRSF10A TNFSF10 12927928 1131930 Lamivudine treatment reduced *mediated* apoptosis and [TRAIL-R1/DR4] expression in Hep G2.2.15 cells . Positive_regulation TNFRSF10A TNFSF10 15389801 1354361 [TRAIL-R1/death] receptor (DR)4 and TRAIL-R2/DR5 are members of the tumor necrosis factor (TNF) receptor family , and can be *activated* by the . Positive_regulation TNFRSF10A TNFSF10 15897906 1426799 HDAC inhibitors *synergized* with by inducing DRs [DR4/TRAIL-R1] and DR5/TRAIL-R2 through NFkappaB activation and some of the proapoptotic members of the Bcl-2 family , and engaging the mitochondrial pathway . Positive_regulation TNFRSF10A TNFSF10 20430723 2181458 *induced* apoptosis and expression of death receptor [TRAIL-R1] and TRAIL-R2 in bladder cancer cells . Positive_regulation TNFRSF10A TNFSF10 24085293 2867502 siRNA mediated depletion of Ack1 disrupted induced *accumulation* of [TRAIL-R1/2] in lipid rafts and efficient recruitment of caspase-8 to the death inducing signaling complex . Positive_regulation TNFRSF10A TNFSF10 24396708 2884012 *upregulates* both [TRAIL-R1] and TRAIL-R2 , accompanied by commensurate susceptibility to spontaneous apoptosis . Positive_regulation TNFRSF10B TNF 16762619 1572178 markedly *increased* the expression of the proapoptotic receptor [TRAIL-R2] . Positive_regulation TNFRSF10B TNF 22301394 2570937 It was found that both CPT and *up-regulated* the expression of [TRAIL receptor 1/2] but not TRAIL in HaCaT cells . Positive_regulation TNFRSF10B TNF 22498762 2601794 Our results indicate that both curcumin and *up-regulated* the expression of [TRAIL-R1/R2] . Positive_regulation TNFRSF10B TNFSF10 11494138 846150 Differential activation of by soluble and membrane TRAIL *allows* selective surface antigen directed activation of [TRAIL-R2] by a soluble TRAIL derivative . Positive_regulation TNFRSF10B TNFSF10 11494138 846152 Using antagonistic antigen binding fragment ( Fab ) preparations of TRAIL-R1- and TRAIL-R2-specific antibodies , we demonstrate in this study that TRAIL-R1 becomes activated by both the soluble and the membrane bound form of the ligand , whereas [TRAIL-R2] becomes only *activated* by memTRAIL or soluble secondarily cross linked by antibodies . Positive_regulation TNFRSF10B TNFSF10 12610517 1063410 Newly synthesised [TRAIL-R2] is functional , so apoptosis is effectively *induced* by , but it is significantly inhibited by constitutive expression of dominant negative p53 . Positive_regulation TNFRSF10B TNFSF10 14655759 1173940 *induced* apoptosis through [death receptor 5 (DR5)] and was mediated by caspase-8 initiated extrinsic and intrinsic mitochondrial pathways in sensitive glioma cell lines . Positive_regulation TNFRSF10B TNFSF10 15389801 1354362 TRAIL-R1/death receptor (DR)4 and [TRAIL-R2/DR5] are members of the tumor necrosis factor (TNF) receptor family , and can be *activated* by the . Positive_regulation TNFRSF10B TNFSF10 15897906 1426800 HDAC inhibitors *synergized* with by inducing DRs DR4/TRAIL-R1 and [DR5/TRAIL-R2] through NFkappaB activation and some of the proapoptotic members of the Bcl-2 family , and engaging the mitochondrial pathway . Positive_regulation TNFRSF10B TNFSF10 17273769 1691724 Fenretinide up-regulates [DR5/TRAIL-R2] expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and *induces* synergistic apoptosis in colon cancer cell lines . Positive_regulation TNFRSF10B TNFSF10 20430723 2181459 *induced* apoptosis and expression of death receptor TRAIL-R1 and [TRAIL-R2] in bladder cancer cells . Positive_regulation TNFRSF10B TNFSF10 21115542 2383601 cell *mediated* activation of [TRAIL-R2/DR5] plays an important role during acute injury in NEMO ( ?hepa ) mice . Positive_regulation TNFRSF10B TNFSF10 24396708 2884013 *upregulates* both TRAIL-R1 and [TRAIL-R2] , accompanied by commensurate susceptibility to spontaneous apoptosis . Positive_regulation TNFRSF10C TNFSF10 12390973 1001655 Stimulation of microglia with *increased* further expression of [TRAIL-R3] , but it had no effect on the expression of TRAIL receptors by ahOL . Positive_regulation TNFRSF10C TNFSF10 20451496 2275278 *upregulates* [decoy receptor 1] and mediates resistance to apoptosis in insulin secreting INS-1 cells . Positive_regulation TNFRSF10D TNFSF10 17867593 1669097 In CM , *induced* [TRAIL-R4] surface expression . Positive_regulation TNFRSF11B CTGF 23722620 2853921 Our results revealed that *induced* the expression of several bone markers , including alkaline phosphatase (ALP) , osteocalcin (OC) , [osteoprotegerin (OPG)] and core binding factor subunit a1 ( Cbfa1 ) /runt related transcription factor 2 ( Runx2 ) , as well as calcification . Positive_regulation TNFRSF11B IL1B 10469276 641069 and tumor necrosis factor-alpha (TNF-alpha) *increased* [OPG/OCIF] mRNA levels in a dose-and time dependent manner in HPDL . Positive_regulation TNFRSF11B IL1B 10469276 641071 After 12 h of treatment , at 3 ng/ml and TNF-alpha at 3 ng/ml *increased* [OPG/OCIF] mRNA expression by 190 % and 110 % , respectively , with a maximal effect . Positive_regulation TNFRSF11B IL1B 11762937 887860 [OPG] was detected by Western blotting , and was *increased* in response to stimulation . Positive_regulation TNFRSF11B IL1B 12126649 966055 In the present study , we examined the involvement of PGE ( 2 ) in *induced* increases in [OPG] levels in human periodontal ligament cells ( HPL cells ) in an effort to clarify apparently conflicting IL-1beta actions on bone resorption and understand IL-1beta induced increases in secretion of OPG and PGE ( 2 ) in HPL cells . Positive_regulation TNFRSF11B IL1B 12126649 966056 These findings suggest that the increase in [OPG] levels *induced* by in HPL cells is suppressed through PGE ( 2 ) synthesized de novo . Positive_regulation TNFRSF11B IL1B 17009257 1634043 In addition , interface membrane fibroblasts expressed RANKL and [osteoprotegerin] in *response* to stimulation with conditioned media , TNFalpha , or . Positive_regulation TNFRSF11B IL1B 17501665 1783807 We also examined whether [OPG] production in *response* to influences TRAIL induced apoptosis in MG-63 cells . Positive_regulation TNFRSF11B IL1B 17501665 1783809 The use of the specific inhibitors showed that p38 and ERK but not JNK were needed for *induced* [OPG] production . Positive_regulation TNFRSF11B IL1B 17501665 1783810 In contrast , NF-kappaB was not essential for *induction* of [OPG] . Positive_regulation TNFRSF11B IL1B 17501665 1783816 Exogenous OPG blocked TRAIL induced apoptosis , but *induction* of [OPG] did not influence TRAIL induced cell death . Positive_regulation TNFRSF11B IL1B 17501665 1783817 *stimulates* [OPG] production by mechanisms dependent on p38 and ERK . Positive_regulation TNFRSF11B IL1B 19301089 2094038 In group 1 ( risedronate plus calcium/vitamin D-treated patients ) , serum levels of RANKL and significantly decreased and the level of [osteoprotegerin] significantly *increased* after three and 6 months , but no significant difference was found in TNF-alpha level . Positive_regulation TNFRSF11B IL1B 19406240 2095653 In PC-3 cells , *stimulated* IL-6 and [OPG] release , and dexamethasone dose-dependently inhibited IL-1beta-inducible IL-6 release , and constitutive and IL-1beta-inducible OPG release . Positive_regulation TNFRSF11B IL1B 19406240 2095655 In LNCaP cells , *stimulated* only [OPG] release . Positive_regulation TNFRSF11B IL1B 19762475 2163491 [OPG] and membranous RANKL levels were significantly *enhanced* by IL-1beta , TNF-alpha and PGE ( 2 ) , whereas membranous RANK was significantly increased only with . Positive_regulation TNFRSF11B IL1B 20204061 2181004 These results suggest that suppresses the formation of osteoclast-like cells via increased OPG production and decreased M-CSF production in chondrocytes , and [OPG] production may *increase* through an autocrine mechanism involving celecoxib related PGs . Positive_regulation TNFRSF11B IL1B 20590617 2285809 All p38MAPK inhibitors significantly inhibited the *induced* gene expression of COX-2 , mPGES1 , iNOS , matrix metalloproteinase 13 (MMP13) and [TNFRSF11B] , as well as PGE ( 2 ) release . Positive_regulation TNFRSF11B TGM2 24265865 2869844 Gene silencing of also signifi cantly *suppressed* the expression of [OPG] in MG-63 cells . Positive_regulation TNFRSF11B TGM2 24265865 2869846 All together , OPG and is induced by IL-1ß or TPA in MG-63 cells and Tgase-2 is *involved* in [OPG] expression in MG-63 cells . Positive_regulation TNFRSF11B TNF 10469276 641068 Interleukin-1beta (IL-1beta) and *increased* [OPG/OCIF] mRNA levels in a dose-and time dependent manner in HPDL . Positive_regulation TNFRSF11B TNF 10469276 641070 After 12 h of treatment , IL-1beta at 3 ng/ml and at 3 ng/ml *increased* [OPG/OCIF] mRNA expression by 190 % and 110 % , respectively , with a maximal effect . Positive_regulation TNFRSF11B TNF 11162596 782267 Using this ELISA , the amount of OPG secreted from human bone marrow stromal cells was clearly detectable , and the secretion of [OPG-protein] was potently *regulated* by prostaglandin E ( 2 ) , forskolin , phorbol 12,13 di butyrate , IL-1 alpha , , and dexamethasone . Positive_regulation TNFRSF11B TNF 12930661 1132343 prohibits the proliferation of PDLCs but *enhances* their [OPG] secretion . Positive_regulation TNFRSF11B TNF 14653607 1173781 Endothelial cell [OPG] mRNA levels were *regulated* by and VEGF , but not by hypoxia . Positive_regulation TNFRSF11B TNF 14994384 1216183 *promotes* the expression of [osteoprotegerin] in rheumatoid synovial fibroblasts . Positive_regulation TNFRSF11B TNF 14994384 1216184 To clarify the regulation of osteoprotegerin (OPG) expression in rheumatoid synovial fibroblasts by investigating the effect of tumor necrosis factor-alpha (TNF-alpha) and the mechanism of *induced* [OPG] expression . Positive_regulation TNFRSF11B TNF 14994384 1216186 *induced* [OPG] expression in all synovial fibroblasts , even OA and noninflammatory fibroblasts , and expression occurred to a remarkable degree in RA fibroblasts . Positive_regulation TNFRSF11B TNF 14994384 1216187 *induced* [OPG] expression was inhibited by hymenialdisine , a nuclear factor-kappaB inhibitor , in a dose dependent manner , and expression was inhibited by soluble TNF receptor/Fc fusion protein I ( TNFs-RI/Fc ) , not by TNFs-RII/Fc . Positive_regulation TNFRSF11B TNF 14994384 1216188 *induced* [OPG] expression is mediated predominantly through TNF-RI . Positive_regulation TNFRSF11B TNF 14994384 1216189 Although TNF-alpha is known to stimulate bone destruction , *induced* upregulation of [OPG] may contribute to self-protection from the bone destruction in RA . Positive_regulation TNFRSF11B TNF 15003795 1217305 PMMA and both stimulated M-CSF and sRANKL production whereas PMMA decreased and TNF-alpha *augmented* [OPG] release by Ob . Positive_regulation TNFRSF11B TNF 15003795 1217307 The ratio [sRANKL/OPG] was significantly *increased* with PMMA and , and treatment with anti-IL-6 antibodies did not alter this ratio . Positive_regulation TNFRSF11B TNF 15270863 1276482 Neither IL-6 nor *increased* the production of [OPG] from FLS . Positive_regulation TNFRSF11B TNF 15479886 1319913 IL18 , IL1 beta , and did not *induce* M-CSF , GM-CSF , IFN gamma , or [OPG] production in PHA prestimulated T cells or RA synovial T cells . Positive_regulation TNFRSF11B TNF 15642135 1363110 *induced* IL-6 and [OPG] production by synoviocytes , which was further increased with patient plasma dilutions and inhibited by infliximab . Positive_regulation TNFRSF11B TNF 17009257 1634042 In addition , interface membrane fibroblasts expressed RANKL and [osteoprotegerin] in *response* to stimulation with conditioned media , , or IL-1beta . Positive_regulation TNFRSF11B TNF 17070781 1675182 Statins decrease *induced* [osteoprotegerin] production by endothelial cells and smooth muscle cells in vitro . Positive_regulation TNFRSF11B TNF 17070781 1675183 Using an ELISA we could demonstrate that statins reduce *induced* [OPG] production in cultured human endothelial cells and smooth muscle cells . Positive_regulation TNFRSF11B TNF 17070781 1675185 A significant reduction of *induced* [OPG] was seen when statins were used in the nanomolar range . Positive_regulation TNFRSF11B TNF 17070781 1675186 The effect of statins on *induced* [OPG] production was reversed by mevalonate and geranyl-geranyl pyrophosphate at the level of protein production and at the level of mRNA expression , suggesting that it was brought about by inhibition of the mevalonic acid pathway and protein prenylation . Positive_regulation TNFRSF11B TNF 17341304 1760090 The expression of [OPG] and RANK by normal human blood neutrophils , however , can be *induced* by interleukin-4 + and by SFs from patients with RA . Positive_regulation TNFRSF11B TNF 17963332 1820261 In contrast , *increased* the expression of both [OPG] and RANKL in a time dependent manner . Positive_regulation TNFRSF11B TNF 19762475 2163490 [OPG] and membranous RANKL levels were significantly *enhanced* by IL-1beta , and PGE ( 2 ) , whereas membranous RANK was significantly increased only with IL-1beta . Positive_regulation TNFRSF11B TNF 9784422 540795 Interleukin (IL)-1beta ( 5 x 10 ( -9 ) M ) , ( 9 x 10 ( -9 ) M ) , and bone morphogenetic protein (BMP)-2 ( 100 ng/ml ) also *increased* [OPG] mRNA levels in hFOB cells by 4- , 6- , and 4-fold , respectively . Positive_regulation TNFRSF12A PGC 24327607 2916921 Intriguingly , muscle-specific overexpression of also *prevented* the inducible expression of [Fn14] in denervated skeletal muscle . Positive_regulation TNFRSF12A PGC 24327607 2916922 Overexpression of not only blocks the TWEAK induced atrophy program but also *diminishes* the expression of [Fn14] in denervated skeletal muscle . Positive_regulation TNFRSF12A TNF 21893119 2506498 Conversely , activation of caspase by exogenous *required* IL-13 , TWEAK , and [Fn14] . Positive_regulation TNFRSF1A FAS 16462206 1522796 We report here that death receptor-5 (DR5) , tumor necrosis factor receptor-1 ( TNF-R1 ) , and are all located in the caveolin-1 enriched membrane fractions , and TRAIL *caused* the translocation of DR5 , FasR , and [TNF-R1] to the caveolar fractions . Positive_regulation TNFRSF1A FAS 17395209 1766123 [TNFR1] ligation *induces* NFkappaB activation and the upregulation of chemokines MCP-1 and IL-8 , as well as adhesion molecules ICAM-1 and VCAM-1 , while and DR5 triggering activate the extracellular signal regulated kinases-1 and -2 ( Erk 1/2 , p42/44 MAPK ) inducing the release of matrix metalloproteinase 9 (MMP9) by BBB derived ECs . Positive_regulation TNFRSF1A FUT4 17410536 1736332 Simultaneously , *up-regulated* the expression of [tumor necrosis factor receptor-1 (TNFR1)] , which in turn activated the proapoptotic caspase-8 and Bid pathways and induced apoptosis in pancreatic cancer cells . Positive_regulation TNFRSF1A FUT4 17410536 1736365 Furthermore , expression of the transcription factor PEA3 was up-regulated by FUT-175 and was involved in *mediated* [TNFR1] expression . Positive_regulation TNFRSF1A IL1B 18515164 1934176 To summarize , presence of *increases* the expression of IL-1 R1 and [TNF RI] and induces expression of TNF RII in the airway wall . Positive_regulation TNFRSF1A TNF 10190941 603443 We present here evidence that the sole *stimulation* of [CD 120a] , but not of CD120b , by is responsible for bot monocytic maturation and apoptosis of primary AML blasts . Positive_regulation TNFRSF1A TNF 10357816 618409 Induction of cell death by tumour necrosis factor (TNF) receptor 2 , CD40 and CD30 : a role for [TNF-R1] *activation* by endogenous membrane anchored . Positive_regulation TNFRSF1A TNF 10357816 618411 Here we demonstrate in different cellular systems that cytotoxic effects induced by TNF-R2 , CD40 and CD30 are mediated by endogenous production of and autotropic or paratropic *activation* of [TNF-R1] . Positive_regulation TNFRSF1A TNF 11591379 869473 Previous studies in TNF receptor (TNFR)-deficient preadipocytes have demonstrated that the anti-adipogenic effect of both secreted and transmembrane is *mediated* solely by [TNFR1] . Positive_regulation TNFRSF1A TNF 14965271 1208862 For example , *activates* [TNF-R1] while FasL and TL1A activate Fas and DR3 respectively . Positive_regulation TNFRSF1A TNF 15115707 1279362 Both kinases associate with [TNFR-1] in *response* to and are required for TNFR-1 serine phosphorylation , NF-kappaB activation , and inhibition of apoptosis . Positive_regulation TNFRSF1A TNF 15115707 1279369 Coimmunoprecipitation studies established that PI 3-kinase , delta-PKC , and [TNFR-1] formed a signal complex in *response* to . Positive_regulation TNFRSF1A TNF 15115707 1279376 Thus delta-PKC and PI 3-kinase are positive regulators of *mediated* association of TRAF2 and RIP with [TNFR-1] . Positive_regulation TNFRSF1A TNF 15160396 1252757 In addition to direct cytotoxic effects , IFN-gamma and also *enhance* the expression of Fas , [TNFR1] , and MHC class I molecules in both cell lines . Positive_regulation TNFRSF1A TNF 15240695 1270339 Immunoprecipitation of cells with Syk Abs showed *dependent* association of Syk with both [TNFR1] and TNFR2 ; Positive_regulation TNFRSF1A TNF 16037484 1466038 In these studies , the enzymatically inactive form of AP had no effect on *induced* RANTES secretion , shedding of sTNFR1 , or membrane associated [TNFR1] . Positive_regulation TNFRSF1A TNF 17328054 1711886 Modulation of may contribute to the regulation of tissue damage , and n-6 polyunsaturated fatty acids ( PUFAs ) such as arachidonic acid ( AA ) can *increase* the expression of [TNFRI] and TNFRII on neutrophils . Positive_regulation TNFRSF1A TNF 17500068 1761793 [TNFR1] , but not TNFR2 , also *mediates* a potent effect of on the phosphorylation of JNK1/2 and p38 stress activated protein kinase and their downstream transcription factor substrates c-Jun and activating transcription factor 2 ( ATF2 ) . Positive_regulation TNFRSF1A TNF 17575006 1786111 We conclude that *induces* MUC1 gene transcription through a [TNFR1] -- > MEK1/2 -- > ERK1 -- > Sp1 pathway . Positive_regulation TNFRSF1A TNF 17646260 1829646 *Activation* of [TNFR1] or DR5 by or TRAIL may regulate osteoblast connectivity , which is important to bone turnover . Positive_regulation TNFRSF1A TNF 18583989 1972138 This paradoxical effect is associated with NF-kappaB dependent pronounced secretion of which *activates* [TNF-R1] in an autocrine fashion to enhance UVB induced apoptosis . Positive_regulation TNFRSF1A TNF 18838114 1988244 DXMb protects the organ of Corti against TNFalpha ototoxicity by up-regulating Bcl-2 and Bcl-xl expression and by inhibiting *induced* increases in Bax , [TNFR1] , and the Bax/Bcl-2 ratio . Positive_regulation TNFRSF1A TNF 18925972 1982070 [TNF receptor 1 (TNFR1)] is expressed in most cell types , and can be *activated* by binding of either soluble ( solTNF ) or transmembrane TNF ( tmTNF ) , with a preference for solTNF ; Positive_regulation TNFRSF1A TNF 18981220 2015195 Consistent with this , TRAF2 phosphorylation is not required for its recruitment to the [TNFR1] complex in *response* to stimulation but is required for its association with a cytoplasmic complex containing RIP1 and IKK . Positive_regulation TNFRSF1A TNF 19400895 2089514 IFN-gamma and *up-regulated* [TNFR1] , TNFR2 , Fas and membrane FasL on SMC . Positive_regulation TNFRSF1A TNF 19772290 2168391 In contrast , [TNFR1] ( -Fas ) is strongly *activated* by spaced within up to 200 nm distances , whereas larger spacings of 290 nm fails completely . Positive_regulation TNFRSF1A TNF 20333651 2266134 Furthermore , *induced* [TNFR1] and TRAF2 complex formation was revealed by immunoprecipitation using an anti-TNFR1 Ab followed by Western blot analysis against an anti-TRAF2 or anti-TNFR1 Ab . Positive_regulation TNFRSF1A TNF 20566746 2296077 In ccRCC organ cultures , *increases* [TNFR1] , activates apoptotic signaling kinase and NF-kappaB , and promotes apoptosis in malignant TECs . Positive_regulation TNFRSF1A TNF 21152874 2373401 Cellular localizations of LR-associated molecules ( ceramides , Gai-2 heterotrimeric protein , and TNF-R1 ) in different cellular compartments including the plasma membrane were observed in the respective photographs from TEM and SEM. Evidence from SEM also showed that [TNF-R1] is clustered on the surface of COLO 205 cells without presence of cognate ligand but clustering is *promoted* by , while it vanished after IMP treatment . Positive_regulation TNFRSF1A TNF 21191629 2425305 The presence of [TNFR1] protein and induced *activation* of MAPK pathways was examined by immunoblotting analysis . Positive_regulation TNFRSF1A TNF 21191629 2425308 The effects of were *mediated* by [TNFR1] . Positive_regulation TNFRSF1A TNF 21191629 2425313 These results demonstrate that increases expression and release of IL-6 by HUCs and that the effects of TNF-a are *mediated* by [TNFR1] . Positive_regulation TNFRSF1A TNF 21816064 2472806 High glucose increased TNF-a production by HCAECs and exogenous *up-regulated* [TNF-R1] and Fas expression in HCAECs . Positive_regulation TNFRSF1A TNF 22417305 2572667 CD4+ CD26- lymphocytes from the peripheral blood of patients with SzS and healthy controls were negatively selected using CD4 and CD26 magnetic beads and analysed for expression of [TNFR1] , TNFR2 , IER3 expression , and ROS production in *response* to at an apoptotic dose . Positive_regulation TNFRSF1A TNF 23676465 2791568 Both the antitumor and inflammatory effects of are *mediated* by the TNF receptor [p55] ( p55TNFR ) ( encoded by the Tnfrsf1a gene ) . Positive_regulation TNFRSF1A TNF 23677929 2801123 Finally , our data suggest that the IRA isoform and its association with [TNF-R1] or IGF-IR confers proliferative advantage to VSMCs , mainly in *response* to or IGF-II , which might be of significance in the early atherosclerotic process . Positive_regulation TNFRSF1A TNF 23869211 2817621 These data demonstrate that activation of intrinsic glomerular cells by soluble *requires* [TNFR1] , whereas TNFR2 is not essential , but augments TNFR1 dependent effects . Positive_regulation TNFRSF1A TNF 23921304 2861638 stimulation *resulted* in a significant decrease in [TNFR1] , an effect that was abolished by pretreatment with EGCG . Positive_regulation TNFRSF1A TNF 23975421 2942261 Bone marrow ( BM ) transplantation experiments showed that expressed by BM-derived cells ( BMDCs ) *stimulates* the [TNFR1] on BMDCs by an autocrine or paracrine manner , which is important for gastric tumor promotion . Positive_regulation TNFRSF1A TNF 24502696 2914082 *stimulated* [TNFR1] , TRAF2 , and c-Src complex formation was revealed by immunoprecipitation and Western blot . Positive_regulation TNFRSF1A TNF 7535144 287783 Whereas [TNFR55] is involved in most observed *responses* to , signaling of TNFR75 appears to be restricted to inhibitory effects on primitive progenitors . Positive_regulation TNFRSF1A TNFSF10 16462206 1522797 We report here that death receptor-5 (DR5) , tumor necrosis factor receptor-1 ( TNF-R1 ) , and Fas receptor (FasR) are all located in the caveolin-1 enriched membrane fractions , and *caused* the translocation of DR5 , FasR , and [TNF-R1] to the caveolar fractions . Positive_regulation TNFRSF1A TNFSF10 16462206 1522802 Our results provide the first evidence for the caveolar localization of [TNF-R1] and DR5 and the coordinated redistribution among membrane fractions of several death receptors in *response* to . Positive_regulation TNFRSF1A TNFSF10 17646260 1829647 *Activation* of [TNFR1] or DR5 by TNF-alpha or may regulate osteoblast connectivity , which is important to bone turnover . Positive_regulation TNFRSF1B IL1B 18515164 1934178 To summarize , presence of increases the expression of IL-1 R1 and TNF RI and *induces* expression of [TNF RII] in the airway wall . Positive_regulation TNFRSF1B IL1B 19231998 2072044 rapidly and persistently *enhanced* soluble and surface [TNFR2] . Positive_regulation TNFRSF1B TNF 10190941 603444 We present here evidence that the sole *stimulation* of CD 120a , but not of [CD120b] , by is responsible for bot monocytic maturation and apoptosis of primary AML blasts . Positive_regulation TNFRSF1B TNF 11324713 807347 The *induction* of [TNF-R2] gene expression by was dose dependent and seemed to be unique to TNF-alpha , as interleukin-6 (IL-6) had no significant effect on TNF-R2 expression . Positive_regulation TNFRSF1B TNF 11772515 899329 T cells from aged subjects show increased sensitivity to *induced* apoptosis that is associated with increased expression of TNF-RI and decreased expression of [TNF-RII] in both CD4+ and CD8+ T cells . Positive_regulation TNFRSF1B TNF 11907088 923256 Here we demonstrate that CD40 induced stimulates IgM production through CD120b and that [CD120b] signaling is *required* for optimal CD40 induced IgM secretion . Positive_regulation TNFRSF1B TNF 12730147 1106749 The enhancing effect of TNF-alpha on carbachol induced isometric force generation was completely abrogated in the tracheal rings obtained from TNF-alpha receptor (TNFR)1-deficient mice and in control rings treated with a mutant that solely *activates* [TNFR2] . Positive_regulation TNFRSF1B TNF 14656985 1177203 Our data demonstrate that excessive *stimulates* [TNF-RII] and enhances migration of ESCs in vitro . Positive_regulation TNFRSF1B TNF 15240695 1270340 Immunoprecipitation of cells with Syk Abs showed *dependent* association of Syk with both TNFR1 and [TNFR2] ; Positive_regulation TNFRSF1B TNF 15993916 1446884 Additionally , there were significant positive correlations between the changes in provirus load and TNF-RII mRNA levels , and *induced* proliferation and [TNF-RII] mRNA levels . Positive_regulation TNFRSF1B TNF 16195372 1462896 Wild-type *induces* [TNFR2] and Etk and activates both ASK1 and Etk but does not down-regulate TNFR1 . Positive_regulation TNFRSF1B TNF 17328054 1711887 Modulation of may contribute to the regulation of tissue damage , and n-6 polyunsaturated fatty acids ( PUFAs ) such as arachidonic acid ( AA ) can *increase* the expression of TNFRI and [TNFRII] on neutrophils . Positive_regulation TNFRSF1B TNF 17500068 1761794 TNFR1 , but not [TNFR2] , also *mediates* a potent effect of on the phosphorylation of JNK1/2 and p38 stress activated protein kinase and their downstream transcription factor substrates c-Jun and activating transcription factor 2 ( ATF2 ) . Positive_regulation TNFRSF1B TNF 18397796 1893677 In addition , EGCG attenuated *mediated* down-regulation of TNFalpha receptor 1 (TNFR1) , but not [TNFR2] . Positive_regulation TNFRSF1B TNF 20038584 2211141 In accord with earlier findings demonstrating that only membrane , but not soluble TNF , properly *activates* [TNFR2] , we further show by use of TNFR1- and TNFR2-specific mutants of soluble TNF and membrane TNF that soluble ligand trimers fail to activate the alternative NFkappaB pathway . Positive_regulation TNFRSF1B TNF 20705117 2329969 TNF mRNA and protein expressions in the cultured epithelial cells were increased by and interleukin-1a , and the [TNFRII] mRNA expressions were *stimulated* by oxytocin . Positive_regulation TNFRSF1B TNF 21631498 2450651 [TNFR2] is preferentially expressed by highly functional human and mouse Treg cells , and *mediates* the activating effect of on Treg cells . Positive_regulation TNFRSF1B TNF 22417305 2572668 CD4+ CD26- lymphocytes from the peripheral blood of patients with SzS and healthy controls were negatively selected using CD4 and CD26 magnetic beads and analysed for expression of TNFR1 , [TNFR2] , IER3 expression , and ROS production in *response* to at an apoptotic dose . Positive_regulation TNFRSF1B TNF 22915753 2683080 Together , our results define a pathway for macrophage induced bystander effects in which *triggers* [TNFRSF1b] receptor signaling leading to increased production of Netrin-1 , crypt hyperplasia , and decreased epithelial cell apoptosis . Positive_regulation TNFRSF1B TNF 23385062 2787017 We propose a novel mechanism in which *activates* [TNFR2] on Treg cells and thereby expands this immunosuppressive immune cell population . Positive_regulation TNFRSF1B TNF 8521496 336428 Intriguingly , *activation* of [TNFR80] by membrane can lead to qualitatively different TNF responses such as rendering resistant tumor cells sensitive to TNF mediated cytotoxicity . Positive_regulation TNFRSF1B TNF 8807591 382863 Down-regulation and shedding of TNF-R1 induced by IL-1 , and the transient expression of [TNF-R2] *induced* by IL-1 and , may regulate the responses to TNF by HPMC . Positive_regulation TNFRSF1B TNF 9496711 490261 Selective *induction* of [tumor necrosis factor receptor type II] gene expression by in C6 glioma cells . Positive_regulation TNFRSF1B TNF 9496711 490262 The *induction* of [TNF-R2] gene expression by was dose dependent and seemed to be unique to TNF-alpha , as IL-6 had no effect . Positive_regulation TNFRSF21 TNF 11753679 890177 *induces* the expression of [DR6] , a member of the TNF receptor family , through activation of NF-kappaB . Positive_regulation TNFRSF4 TNF 15578092 1344760 We found that *induced* [OX40] expression on T cells and blocking the interaction between either CD40 and its ligand or OX40 and its ligand suppressed development of arthritis . Positive_regulation TNFRSF4 TNF 18327975 1886309 We have previously reported that *stimulation* of the [OX40] expressing and HIV-1 chronically infected T cell line , ACH-2/OX40 , with either OX40 ligand (OX40L) expressing cells or with resulted in the activation of HIV-1 followed by apoptotic cell death . Positive_regulation TNFRSF4 TNF 20181891 2229105 FACS analysis revealed that also *induced* upregulation of cell surface expression of 4-1BB and [OX40] specifically in CD45RA ( - ) FOXP3 ( + ) Tregs . Positive_regulation TNFRSF4 TNF 9766631 538398 [CD134] expression could be *induced* by interleukin-4 , but not by interferon-gamma or . Positive_regulation TNFRSF6B TNF 17393415 1728003 *increased* [DcR3] expression and inhibited Fas induced apoptosis in RA FLS , but not in OA FLS . Positive_regulation TNFRSF6B TNF 17393415 1728004 [DcR3] expressed in RA FLS is *increased* by and protects the cells against Fas induced apoptosis . Positive_regulation TNFRSF6B TNFSF10 15475369 1319205 Instead , in the presence of [DcR3] , engagement *resulted* in an increased activation of caspase-8 , an elevated cleavage of Bid , and enhanced release of Smac and cytochrome c from mitochondria to cytosol compared with TRAIL alone . Positive_regulation TNFRSF8 JAG1 8568238 350951 In short-term culture , [CD30] expression could be *induced* on T cells by that elicit Th2-type responses ( Schistosoma haematobium , adult worm Ag , and Toxocaria canis , excretory/secretory Ag ) and Th0-type responses ( tetanus toxoid ) , as well as Th1-type responses ( tuberculin purified protein derivative ) . Positive_regulation TNFRSF8 TNF 7540942 310167 [CD30] cross linking does not alter proliferation of ACH-2 cells and the induction of HIV expression is not *mediated* by endogenous . Positive_regulation TNFRSF9 EPHB2 16493029 1528674 The Ag-independent induction of [4-1BB] by IL-15 was *dependent* on MAPK p38 and activation . Positive_regulation TNFRSF9 FAS 11465097 839599 These results demonstrated that [CD137L] costimulation *induces* a rapid induction of on CD4+ T cells and leads to apoptosis of CD95-sensitive target cells . Positive_regulation TNFRSF9 TNF 20008291 2191253 The expression of [CD137] on activated human B cells is functionally relevant because engagement with its ligand at the time of activation stimulates B cell proliferation , enhances B cell survival , and *induces* secretion of and -beta . Positive_regulation TNFRSF9 TNF 20181891 2229106 FACS analysis revealed that also *induced* upregulation of cell surface expression of [4-1BB] and OX40 specifically in CD45RA ( - ) FOXP3 ( + ) Tregs . Positive_regulation TNFSF10 ADO 15201983 1260883 In the present study , we report that <8-Cl-Ado> can *promote* [TRAIL] killing activity in the hepatoma cell line BEL-7402 in dose- and time dependent manner when jointly used in vitro . Positive_regulation TNFSF10 AFP 15849812 1399218 ( 20 mg/L ) could *promote* the expression of FasL and [TRAIL] , and inhibit the expression of Fas and TRAILR of Bel7402 cells . Positive_regulation TNFSF10 AKR1C4 17283156 1698225 Furthermore , we show that overexpression of the active form of Akt by adenovirus infection or inhibition of the Akt downstream target glycogen synthase kinase 3 by its pharmacologic inhibitors abolishes [TRAIL] *induction* by <5-aza-CdR> . Positive_regulation TNFSF10 AKT1 12140294 985195 Moreover , overexpression of active , a downstream target of PI 3-kinase , or inhibition of GSK-3 , a downstream target of active Akt , completely *blocked* the induction of [TRAIL] by wortmannin . Positive_regulation TNFSF10 AKT1 12807432 1101887 [TRAIL] rapidly ( from 20 min ) *induced* the phosphorylation of and ERK , but not of c-Jun NH2-terminal kinase (JNK) . Positive_regulation TNFSF10 AKT1 15289937 1278537 Western blot analysis consistently showed that [TRAIL] *induced* a significant activation of ERK1/2 , and a much weaker phosphorylation of , while it did not affect the p38/MAPK pathway . Positive_regulation TNFSF10 AKT1 15711939 1373688 Conversely , [TRAIL] *induced* caspase dependent cleavage of neutralizing its anti-apoptotic effects . Positive_regulation TNFSF10 AKT1 21109947 2366257 Akt catalytic activation is known to increase during metabolic oxidative stress , but we show that [TRAIL] also dramatically *induces* the catalytic activation of in TRAIL-sensitive cells , but not in TRAIL-resistant cells . Positive_regulation TNFSF10 AKT1 21472268 2361576 Our data demonstrated that the *activation* of and NF-?B by [TRAIL] is responsible for resistance to TRAIL in human gastric cancer cells . Positive_regulation TNFSF10 AKT2 12140294 985196 Moreover , overexpression of active , a downstream target of PI 3-kinase , or inhibition of GSK-3 , a downstream target of active Akt , completely *blocked* the induction of [TRAIL] by wortmannin . Positive_regulation TNFSF10 AKT2 12807432 1101888 [TRAIL] rapidly ( from 20 min ) *induced* the phosphorylation of and ERK , but not of c-Jun NH2-terminal kinase (JNK) . Positive_regulation TNFSF10 AKT2 15289937 1278538 Western blot analysis consistently showed that [TRAIL] *induced* a significant activation of ERK1/2 , and a much weaker phosphorylation of , while it did not affect the p38/MAPK pathway . Positive_regulation TNFSF10 AKT2 15711939 1373689 Conversely , [TRAIL] *induced* caspase dependent cleavage of neutralizing its anti-apoptotic effects . Positive_regulation TNFSF10 AKT2 21109947 2366258 Akt catalytic activation is known to increase during metabolic oxidative stress , but we show that [TRAIL] also dramatically *induces* the catalytic activation of in TRAIL-sensitive cells , but not in TRAIL-resistant cells . Positive_regulation TNFSF10 AKT2 21472268 2361577 Our data demonstrated that the *activation* of and NF-?B by [TRAIL] is responsible for resistance to TRAIL in human gastric cancer cells . Positive_regulation TNFSF10 AKT3 12140294 985197 Moreover , overexpression of active , a downstream target of PI 3-kinase , or inhibition of GSK-3 , a downstream target of active Akt , completely *blocked* the induction of [TRAIL] by wortmannin . Positive_regulation TNFSF10 AKT3 12807432 1101889 [TRAIL] rapidly ( from 20 min ) *induced* the phosphorylation of and ERK , but not of c-Jun NH2-terminal kinase (JNK) . Positive_regulation TNFSF10 AKT3 15289937 1278539 Western blot analysis consistently showed that [TRAIL] *induced* a significant activation of ERK1/2 , and a much weaker phosphorylation of , while it did not affect the p38/MAPK pathway . Positive_regulation TNFSF10 AKT3 15711939 1373690 Conversely , [TRAIL] *induced* caspase dependent cleavage of neutralizing its anti-apoptotic effects . Positive_regulation TNFSF10 AKT3 21109947 2366259 Akt catalytic activation is known to increase during metabolic oxidative stress , but we show that [TRAIL] also dramatically *induces* the catalytic activation of in TRAIL-sensitive cells , but not in TRAIL-resistant cells . Positive_regulation TNFSF10 AKT3 21472268 2361578 Our data demonstrated that the *activation* of and NF-?B by [TRAIL] is responsible for resistance to TRAIL in human gastric cancer cells . Positive_regulation TNFSF10 ASIP 23754197 2801945 We demonstrated that *induced* cell death through the activation of [TRAIL] DR4/DR5 death receptors leading to the activation of caspase-8 and caspase-3 and to cell apoptosis . Positive_regulation TNFSF10 BAX 11355877 815459 [TRAIL] did not *induce* expression and/or translocation from cytosol to mitochondria in the K562 cell line . Positive_regulation TNFSF10 BAX 12082629 958663 [TRAIL] *induced* translocation of subsequent to the cleavage of Bid in parental cells . Positive_regulation TNFSF10 BAX 20137126 2208046 [TRAIL] *induced* apoptosis in RPMI8226 cells , the expression level of genes bcl-2 , mcl-1 , CARP1 , CARP2 , XIAP and cFLIP decreased , while the expression level of increased , but the expression level of caspase-3 and NF-kappaB P65 ( RelA ) proteins decreased . Positive_regulation TNFSF10 BCL2 12592338 1060371 We did not observe a protective effect of Bcl-X ( L ) or against the cytotoxic activity of TRAIL , even though [TRAIL] *induced* cleavage of BID . Positive_regulation TNFSF10 BID 12592338 1060370 We did not observe a protective effect of Bcl-X ( L ) or Bcl-2 against the cytotoxic activity of TRAIL , even though [TRAIL] *induced* cleavage of . Positive_regulation TNFSF10 BIRC3 17613437 1768781 [TRAIL] *induced* expression of antiapoptotic Mcl-1 and through activation of NF-kappaB . Positive_regulation TNFSF10 CALR 17953526 1814626 The interaction with *required* a conformational change in CD40L , [TRAIL] and FasL and showed the same characteristics as calreticulin 's interaction with C1q and MBL : a time dependent saturable binding to immobilized protein , which was initially sensitive to salt but gradually developed into a salt-insensitive interaction . Positive_regulation TNFSF10 CASP1 16234248 1489423 AD5-10 induces both dependent and caspase independent cell death in Jurkat cells , whereas [TRAIL] *induces* only caspase dependent cell death . Positive_regulation TNFSF10 CASP1 20599741 2290822 AOA plus [TRAIL] *induced* a dependent apoptotic response . Positive_regulation TNFSF10 CASP1 22991197 2734913 We demonstrate that EGFR targeted [TRAIL] in combination with BZB *induced* significantly higher activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation TNFSF10 CASP10 16234248 1489424 AD5-10 induces both dependent and caspase independent cell death in Jurkat cells , whereas [TRAIL] *induces* only caspase dependent cell death . Positive_regulation TNFSF10 CASP10 20599741 2290823 AOA plus [TRAIL] *induced* a dependent apoptotic response . Positive_regulation TNFSF10 CASP10 22991197 2734914 We demonstrate that EGFR targeted [TRAIL] in combination with BZB *induced* significantly higher activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation TNFSF10 CASP12 16234248 1489434 AD5-10 induces both dependent and caspase independent cell death in Jurkat cells , whereas [TRAIL] *induces* only caspase dependent cell death . Positive_regulation TNFSF10 CASP12 20599741 2290833 AOA plus [TRAIL] *induced* a dependent apoptotic response . Positive_regulation TNFSF10 CASP12 22991197 2734924 We demonstrate that EGFR targeted [TRAIL] in combination with BZB *induced* significantly higher activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation TNFSF10 CASP14 16234248 1489425 AD5-10 induces both dependent and caspase independent cell death in Jurkat cells , whereas [TRAIL] *induces* only caspase dependent cell death . Positive_regulation TNFSF10 CASP14 20599741 2290824 AOA plus [TRAIL] *induced* a dependent apoptotic response . Positive_regulation TNFSF10 CASP14 22991197 2734915 We demonstrate that EGFR targeted [TRAIL] in combination with BZB *induced* significantly higher activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation TNFSF10 CASP16 16234248 1489435 AD5-10 induces both dependent and caspase independent cell death in Jurkat cells , whereas [TRAIL] *induces* only caspase dependent cell death . Positive_regulation TNFSF10 CASP16 20599741 2290834 AOA plus [TRAIL] *induced* a dependent apoptotic response . Positive_regulation TNFSF10 CASP16 22991197 2734925 We demonstrate that EGFR targeted [TRAIL] in combination with BZB *induced* significantly higher activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation TNFSF10 CASP2 11992615 938773 In the presence of wortmannin [TRAIL] induced *activation* of , -3 , -7 , -8 , and -9 , as well as dissipation of mitochondrial transmembrane potential and release of cyto-chrome c from mitochondria into the cytosol . Positive_regulation TNFSF10 CASP2 16234248 1489426 AD5-10 induces both dependent and caspase independent cell death in Jurkat cells , whereas [TRAIL] *induces* only caspase dependent cell death . Positive_regulation TNFSF10 CASP2 20599741 2290825 AOA plus [TRAIL] *induced* a dependent apoptotic response . Positive_regulation TNFSF10 CASP2 22991197 2734916 We demonstrate that EGFR targeted [TRAIL] in combination with BZB *induced* significantly higher activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation TNFSF10 CASP3 11585775 866280 These results suggest that Smac/DIABLO release from mitochondria and its binding to XIAP are an alternative pathway by which [TRAIL] induces apoptosis of melanoma , and this pathway is *dependent* on the release of activated from inhibition by XIAP and possibly other inhibitor of apoptosis family members . Positive_regulation TNFSF10 CASP3 12569162 1057208 Using immobilized B7-H1 mAb 's and programmed death 1Ig , we demonstrate that engagement of B7-H1 on CD4 ( + ) T cells costimulates proliferation and secretion of IL-10 , and subsequently leads to programmed cell death , accompanied with upregulated expression of [TNF related apoptosis inducing ligand] and *activation* of . Positive_regulation TNFSF10 CASP3 16234248 1489427 AD5-10 induces both dependent and caspase independent cell death in Jurkat cells , whereas [TRAIL] *induces* only caspase dependent cell death . Positive_regulation TNFSF10 CASP3 20599741 2290826 AOA plus [TRAIL] *induced* a dependent apoptotic response . Positive_regulation TNFSF10 CASP3 22555452 2614108 Synergistic *activation* of , -8 , and -9 by silibinin and [TRAIL] was shown by colorimetric assays . Positive_regulation TNFSF10 CASP3 22753701 2622986 Silibinin activated the extrinsic apoptotic pathway in Hep55.1C cells , as attested by the up-regulation of [TNF related apoptosis inducing ligand] ( TRAIL ) and TRAIL Death receptor 5 (DR5) transcripts , and by the *activation* of and -8 . Positive_regulation TNFSF10 CASP3 22991197 2734917 We demonstrate that EGFR targeted [TRAIL] in combination with BZB *induced* significantly higher activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation TNFSF10 CASP4 16137006 1353314 The inhibition of ubiquitin-proteasome pathway can sensitize rheumatoid arthritis synovial fibroblast cells to [TRAIL-] induced apoptosis , and the activation of caspase 8 and is *necessary* in this process . Positive_regulation TNFSF10 CASP4 16234248 1489428 AD5-10 induces both dependent and caspase independent cell death in Jurkat cells , whereas [TRAIL] *induces* only caspase dependent cell death . Positive_regulation TNFSF10 CASP4 20599741 2290827 AOA plus [TRAIL] *induced* a dependent apoptotic response . Positive_regulation TNFSF10 CASP4 22991197 2734918 We demonstrate that EGFR targeted [TRAIL] in combination with BZB *induced* significantly higher activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation TNFSF10 CASP5 16234248 1489429 AD5-10 induces both dependent and caspase independent cell death in Jurkat cells , whereas [TRAIL] *induces* only caspase dependent cell death . Positive_regulation TNFSF10 CASP5 20599741 2290828 AOA plus [TRAIL] *induced* a dependent apoptotic response . Positive_regulation TNFSF10 CASP5 22991197 2734919 We demonstrate that EGFR targeted [TRAIL] in combination with BZB *induced* significantly higher activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation TNFSF10 CASP6 16234248 1489430 AD5-10 induces both dependent and caspase independent cell death in Jurkat cells , whereas [TRAIL] *induces* only caspase dependent cell death . Positive_regulation TNFSF10 CASP6 20599741 2290829 AOA plus [TRAIL] *induced* a dependent apoptotic response . Positive_regulation TNFSF10 CASP6 22991197 2734920 We demonstrate that EGFR targeted [TRAIL] in combination with BZB *induced* significantly higher activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation TNFSF10 CASP7 16234248 1489431 AD5-10 induces both dependent and caspase independent cell death in Jurkat cells , whereas [TRAIL] *induces* only caspase dependent cell death . Positive_regulation TNFSF10 CASP7 20599741 2290830 AOA plus [TRAIL] *induced* a dependent apoptotic response . Positive_regulation TNFSF10 CASP7 22991197 2734921 We demonstrate that EGFR targeted [TRAIL] in combination with BZB *induced* significantly higher activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation TNFSF10 CASP8 11115558 768373 TRAIL has no effect on Delta psi ( m ) and apoptosis in Jurkat cells deficient in either FADD or caspase-8 , suggesting both FADD and are *required* for [TRAIL] signaling . Positive_regulation TNFSF10 CASP8 11279540 764692 In addition , expression of Toso , a cell surface apoptosis regulator , seemed to block *activation* of by [TRAIL] via enhanced expression of FLIPL in granulocytic differentiated cells . Positive_regulation TNFSF10 CASP8 11992615 938771 LNCaP is resistant to [TRAIL] but TRAIL transiently *induces* DEVDase activity and activation of ; Positive_regulation TNFSF10 CASP8 15607733 1357002 These data suggest that amiloride sensitizes both tumor cells to TRAIL induced apoptosis by promoting Akt dephosphorylation and activation via the intracellular acidification and that Na ( + ) /H ( + ) exchanger inhibitors may *play* an important role in the anti-cancer activity of [TRAIL] , especially , in TRAIL-resistant tumors with highly active and expressed Akt . Positive_regulation TNFSF10 CASP8 15645141 1363610 In this study , to specify caspase-8 mediated apoptotic activity , we examined the anti-tumor effect of adenoviral vector expressing caspase-8 ( Adv-caspase-8 ) in combination with [TNF related apoptosis inducing ligand] ( TRAIL ) which *induces* specifically activation . Positive_regulation TNFSF10 CASP8 15791480 1386602 As mitochondria related activation of this caspase cascade , through e.g . APAF-1 , could not be proven in dystrophin-deficient muscle , this study searches for other prospective candidates that may directly trigger apoptotic cell degradation by mitochondria independent pathways involving the interaction of tumour necrosis factor-alpha (TNF-alpha) and [TRAIL] with death receptors and subsequent *activation* of . Positive_regulation TNFSF10 CASP8 16137006 1353315 The inhibition of ubiquitin-proteasome pathway can sensitize rheumatoid arthritis synovial fibroblast cells to [TRAIL-] induced apoptosis , and the activation of and caspase 4 is *necessary* in this process . Positive_regulation TNFSF10 CASP8 16234248 1489432 AD5-10 induces both dependent and caspase independent cell death in Jurkat cells , whereas [TRAIL] *induces* only caspase dependent cell death . Positive_regulation TNFSF10 CASP8 18005243 1860152 Collectively , these data suggest that Shiga toxins trigger monocytic cell apoptosis through the ER stress response , the increased expression of DR5 and [TRAIL] , and *activation* of via a calpain dependent mechanism . Positive_regulation TNFSF10 CASP8 18458681 1916386 Roscovitine facilitated [TRAIL] death inducing signaling complex formation and the *activation* of . Positive_regulation TNFSF10 CASP8 19643600 2124994 These two modifications provoked in the presence of TRAIL the rapid production of [TRAIL-DISC] and the *activation* of . Positive_regulation TNFSF10 CASP8 20599741 2290831 AOA plus [TRAIL] *induced* a dependent apoptotic response . Positive_regulation TNFSF10 CASP8 21083988 2349719 [TRAIL] *induces* apoptosis in NB cells with an increase of relative activity . Positive_regulation TNFSF10 CASP8 21835222 2532433 Our results show that SAHA decreased the level of c-FLIP , thus favouring the interaction of [TRAIL] with the specific death receptors DR4 and DR5 and the consequent *activation* of . Positive_regulation TNFSF10 CASP8 22753701 2622987 Silibinin activated the extrinsic apoptotic pathway in Hep55.1C cells , as attested by the up-regulation of [TNF related apoptosis inducing ligand] ( TRAIL ) and TRAIL Death receptor 5 (DR5) transcripts , and by the *activation* of . Positive_regulation TNFSF10 CASP8 22991197 2734922 We demonstrate that EGFR targeted [TRAIL] in combination with BZB *induced* significantly higher activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation TNFSF10 CASP9 16234248 1489433 AD5-10 induces both dependent and caspase independent cell death in Jurkat cells , whereas [TRAIL] *induces* only caspase dependent cell death . Positive_regulation TNFSF10 CASP9 16475717 1524137 [TRAIL] *induced* the activation of caspases-2 , -3 and -8 , but not the activation of , in the Mel-resistant TE-671 cells . Positive_regulation TNFSF10 CASP9 20599741 2290832 AOA plus [TRAIL] *induced* a dependent apoptotic response . Positive_regulation TNFSF10 CASP9 22991197 2734923 We demonstrate that EGFR targeted [TRAIL] in combination with BZB *induced* significantly higher activation and cell death in hepatoma cells , but not in primary hepatocytes . Positive_regulation TNFSF10 CCAR1 20137126 2208044 [TRAIL] *induced* apoptosis in RPMI8226 cells , the expression level of genes bcl-2 , mcl-1 , , CARP2 , XIAP and cFLIP decreased , while the expression level of Bax increased , but the expression level of caspase-3 and NF-kappaB P65 ( RelA ) proteins decreased . Positive_regulation TNFSF10 CCL2 16751802 1645923 Here , we show that [TRAIL] strongly *induces* the expression of the proinflammatory cytokines interleukin-8 and and enhances the invasion of apoptosis-resistant pancreatic ductal adenocarcinoma cells in vitro by upregulation of the urokinase-type plasminogen activator expression . Positive_regulation TNFSF10 CCL20 19120450 2019361 In this article , it is shown that [TRAIL] *induces* CXCL2 , CCL4 and secretion in a nuclear factor kappa B-dependent manner . Positive_regulation TNFSF10 CCL4 19120450 2019362 In this article , it is shown that [TRAIL] *induces* CXCL2 , and CCL20 secretion in a nuclear factor kappa B-dependent manner . Positive_regulation TNFSF10 CCR5 15990565 1429554 The increase in [TRAIL] death receptor expression and acquisition of TRAIL sensitivity *requires* the chemokine coreceptor CXCR4 but not or the CD4 receptor . Positive_regulation TNFSF10 CD4 15585654 1375102 Interestingly , the HIV-1 entry inhibitor , soluble , *blocked* HIV-1 induced production of [TRAIL] . Positive_regulation TNFSF10 CD4 15990565 1429555 The increase in [TRAIL] death receptor expression and acquisition of TRAIL sensitivity *requires* the chemokine coreceptor CXCR4 but not CCR5 or the receptor . Positive_regulation TNFSF10 CD47 22926077 2672518 We suggest that combined post-trauma triggering , SHP-1 mediated NF?B suppression , and elevated [TRAIL] levels *increase* patients ' CD47 expressing T cell apoptosis , thus contributing to subsequent T cell anergy . Positive_regulation TNFSF10 CD59 10760796 683654 cross linking *induces* secretion of [APO2 ligand] in overactivated human T cells . Positive_regulation TNFSF10 CDR1 17283156 1698224 *Induction* of [TRAIL] by <5-aza-CdR> correlated with inactivation of Akt . Positive_regulation TNFSF10 CDR1 17283156 1698226 Taken together , our results suggest that *induction* of [TRAIL] by <5-aza-CdR> is critical for enhancing chemosensitivity of breast cancer cells to Adriamycin . Positive_regulation TNFSF10 CFLAR 20137126 2208043 [TRAIL] *induced* apoptosis in RPMI8226 cells , the expression level of genes bcl-2 , mcl-1 , CARP1 , CARP2 , XIAP and decreased , while the expression level of Bax increased , but the expression level of caspase-3 and NF-kappaB P65 ( RelA ) proteins decreased . Positive_regulation TNFSF10 CNTN2 11553609 869019 Finally , we provide genetic evidence demonstrating that the NF-kappaB signaling pathway is essential for [TRAIL] gene *induction* by both and T-cell activation signals . Positive_regulation TNFSF10 CTSB 17431792 1748960 Cathepsin B activity in U2OS cells was significantly activated shortly after exposure to TRAIL , and the inhibitor , CA074Me , *inhibited* both [TRAIL-] and anti-DR5 mediated apoptosis and delayed the cleavage of Bid . Positive_regulation TNFSF10 CXCR4 15990565 1429556 The increase in [TRAIL] death receptor expression and acquisition of TRAIL sensitivity *requires* the chemokine coreceptor but not CCR5 or the CD4 receptor . Positive_regulation TNFSF10 CYCS 11992615 938774 In the presence of wortmannin [TRAIL] induced *activation* of caspase-2 , -3 , -7 , -8 , and -9 , as well as dissipation of mitochondrial transmembrane potential and release of from mitochondria into the cytosol . Positive_regulation TNFSF10 CYCS 12196516 997850 We found that [TRAIL] receptor could *induce* release from mitochondria in cells that failed to respond to CD95 . Positive_regulation TNFSF10 CYCS 12481428 1024291 Whereas [Apo2L/TRAIL] *induced* the release of and endogenous Smac/DIABLO in the CL-1 tumor cells , the cytosolic levels of both molecules were not sufficient to induce apoptosis . Positive_regulation TNFSF10 CYCS 12670926 1076226 [TRAIL] *induced* release and apoptosis in wild-type , Bid ( -/- ) , Bax ( -/- ) , or Bak ( -/- ) MEFs , but not in Bax ( -/- ) Bak ( -/- ) double knockout ( DKO ) MEFs . Positive_regulation TNFSF10 DDIT3 21292685 2393170 This upregulation of was *followed* by marked upregulation of the [TRAIL] receptor , DR5 . Positive_regulation TNFSF10 DIABLO 12481428 1024292 Whereas [Apo2L/TRAIL] *induced* the release of cytochrome c and endogenous in the CL-1 tumor cells , the cytosolic levels of both molecules were not sufficient to induce apoptosis . Positive_regulation TNFSF10 DIABLO 12792804 1097883 With over-expression of in HCC cells , [TRAIL] *induced* by 10 % HCC cell death . Positive_regulation TNFSF10 DIABLO 16103097 1444533 Data suggest that in the presence of mitochondrial derived ROS , [TRAIL] *induced* mitochondrial release of and inactivation of X-linked inhibitor of apoptosis through caspase-9 independent activation of caspase 3 . Positive_regulation TNFSF10 DISC1 12761581 1091680 [TRAIL] ligation *induced* formation in TRAIL-sensitive ( RD , Rh18 , Rh30 ) and TRAIL-resistant RMS ( Rh28 , Rh36 , Rh41 ) , with recruitment of FADD and procaspase-8 . Positive_regulation TNFSF10 DISC1 22456178 2691305 In TRAIL-resistant gastric cancer cells , [TRAIL] did not *induce* effective formation in lipid rafts , accompanied with EGFR translocation into lipid rafts , and activation of EGFR pathway . Positive_regulation TNFSF10 DISC2 12761581 1091681 [TRAIL] ligation *induced* formation in TRAIL-sensitive ( RD , Rh18 , Rh30 ) and TRAIL-resistant RMS ( Rh28 , Rh36 , Rh41 ) , with recruitment of FADD and procaspase-8 . Positive_regulation TNFSF10 DISC2 22456178 2691306 In TRAIL-resistant gastric cancer cells , [TRAIL] did not *induce* effective formation in lipid rafts , accompanied with EGFR translocation into lipid rafts , and activation of EGFR pathway . Positive_regulation TNFSF10 EPHB2 12807432 1101886 [TRAIL] rapidly ( from 20 min ) *induced* the phosphorylation of Akt and , but not of c-Jun NH2-terminal kinase (JNK) . Positive_regulation TNFSF10 ERVK-6 17479112 1766591 Here we show that the human intracellular serine protease inhibitor ( serpin ) , , *inhibits* TNF- , [TNF related apoptosis inducing ligand-] and Fas ligand mediated apoptosis in certain TNF-sensitive cell lines . Positive_regulation TNFSF10 EZH2 23228130 2736618 *mediated* regulation of [TRAIL] : a new target for cancer therapy . Positive_regulation TNFSF10 FADD 11115558 768374 TRAIL has no effect on Delta psi ( m ) and apoptosis in Jurkat cells deficient in either FADD or caspase-8 , suggesting both and caspase-8 are *required* for [TRAIL] signaling . Positive_regulation TNFSF10 FADD 17786370 1790998 IFN-alpha induced upregulation of TRAIL protein in the dnFADD expressing Daudi or U266 cells was comparable to their control cells , suggesting that is not *involved* in the IFN-alpha induced upregulation of [TRAIL] . Positive_regulation TNFSF10 FASLG 16037714 1437324 and [TNF related apoptosis inducing ligand] *induction* on infiltrating lymphocytes in bladder carcinoma by bacillus Calmette-Guérin treatment . Positive_regulation TNFSF10 FGF2 20150555 2227510 Injury and *regulated* [TRAIL] transcriptional activity via 2 specificity protein (Sp)1 elements in the proximal TRAIL promoter , a binding site also shared by nuclear factor (NF)kappaB . Positive_regulation TNFSF10 FOXO3 20213318 2249200 Similarly to BCR-Abl transformed human cells , activation of the transcription factor *led* to increased [TRAIL] transcription and induction of a G1 arrest in the absence of v-Abl inhibition , and this effect could be inhibited by the expression of a constitutively active AKT mutant . Positive_regulation TNFSF10 FOXO3 20213318 2249205 We conclude that in Abelson cells , the inhibition of both NF-kappaB and activity is *required* for suppression of [TRAIL] transcription and maintenance of the transformed state . Positive_regulation TNFSF10 FOXO3 20215638 2249246 In NB4 derived ATRA-resistant NB4/RA cells , neither nuclear localization nor subsequent [TRAIL] *induction* was observed after ATRA treatment . Positive_regulation TNFSF10 FOXO3 23828551 2824792 *induces* the death ligand [TRAIL] and the BH3-only protein Noxa implicating extrinsic as well as intrinsic death signaling . Positive_regulation TNFSF10 FPR2 17938258 1813837 *mediated* endogenous [TRAIL] gene expression with tumoricidal activity . Positive_regulation TNFSF10 FPR2 17938258 1813838 Activation of nuclear factor kappaB was required by the *mediated* [TRAIL] expression in the human THP-1 cells and primary neutrophils . Positive_regulation TNFSF10 GIF 17628186 1770231 alpha-TOS and [TRAIL] in combination with dendritic cells *induce* production by CD4+ and CD8+ T lymphocytes , resulting in a significant tumor growth inhibition or in complete tumor regression . Positive_regulation TNFSF10 HLA-DRB1 15094781 1266301 Sensitization to [TRAIL] *involved* enhanced death receptor expression , activation of Bid and the complete caspases cascade . Positive_regulation TNFSF10 HLA-DRB1 15385934 1324182 [TRAIL/FP] *induced* no discernible changes in FLIP , , DR5 , Mcl-1 , or survivin expression , modest declines in levels of DcR2 and c-IAP , but resulted in the marked transcriptional downregulation of XIAP . Positive_regulation TNFSF10 HLA-DRB1 15389801 1354365 TRAIL-R1/death receptor (DR)4 and are members of the tumor necrosis factor (TNF) receptor family , and can be *activated* by the [TRAIL] . Positive_regulation TNFSF10 HLA-DRB1 16247474 1518149 Interestingly , these effects were not dependent on *activation* of by its ligand [TRAIL] . Positive_regulation TNFSF10 HLA-DRB1 17646260 1829649 *Activation* of TNFR1 or by TNF-alpha or [TRAIL] may regulate osteoblast connectivity , which is important to bone turnover . Positive_regulation TNFSF10 HLA-DRB1 20354842 2260903 [TRAIL] signaling is *mediated* by in pancreatic tumor cells despite the expression of functional DR5 . Positive_regulation TNFSF10 HLA-DRB1 22093622 2509269 [TRAIL] ( 100 µg/L ) did not *induce* obvious lipid rafts aggregation and death receptor 4 (DR4) clustering , while cisplatin ( 8.49 mg/L ) significantly promoted the localization of in aggregated lipid rafts . Positive_regulation TNFSF10 HNRNPF 11035052 740865 Contrasting with our previous report using cultured splenic DCs , freshly isolated splenic killed YAC-1 cells using a Ca ( 2+ ) -independent mechanism , but this function did not appear *mediated* by Fas ligand , [TNF related apoptosis inducing ligand] , or TNF-alpha . Positive_regulation TNFSF10 HNRNPH1 11035052 740866 Contrasting with our previous report using cultured splenic DCs , freshly isolated splenic killed YAC-1 cells using a Ca ( 2+ ) -independent mechanism , but this function did not appear *mediated* by Fas ligand , [TNF related apoptosis inducing ligand] , or TNF-alpha . Positive_regulation TNFSF10 ICAM1 12874246 1115000 In surviving cells , [TRAIL] activates NF-kappaB , *induces* expression of E-selectin , , and IL-8 , and promotes adhesion of leukocytes . Positive_regulation TNFSF10 IFN1@ 19577819 2117568 [TRAIL] production is only partially *dependent* on the autocrine production of as documented by the use of a blocking anti-IFNRA antibody and the stimulation with exogenous IFN I . Positive_regulation TNFSF10 IFNA1 17617740 1815951 *induces* [TRAIL] expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation TNFSF10 IFNA1 20663526 2305189 did not *induce* changes in [TRAIL] or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation TNFSF10 IFNA10 17617740 1815952 *induces* [TRAIL] expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation TNFSF10 IFNA10 20663526 2305190 did not *induce* changes in [TRAIL] or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation TNFSF10 IFNA13 17617740 1815953 *induces* [TRAIL] expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation TNFSF10 IFNA13 20663526 2305191 did not *induce* changes in [TRAIL] or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation TNFSF10 IFNA14 17617740 1815954 *induces* [TRAIL] expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation TNFSF10 IFNA14 20663526 2305192 did not *induce* changes in [TRAIL] or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation TNFSF10 IFNA16 17617740 1815955 *induces* [TRAIL] expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation TNFSF10 IFNA16 20663526 2305193 did not *induce* changes in [TRAIL] or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation TNFSF10 IFNA17 17617740 1815956 *induces* [TRAIL] expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation TNFSF10 IFNA17 20663526 2305194 did not *induce* changes in [TRAIL] or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation TNFSF10 IFNA2 17617740 1815957 *induces* [TRAIL] expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation TNFSF10 IFNA2 17689283 1788327 A resistant melanoma cell line , A375 , lacked [APO2L/TRAIL] or apoptosis *induction* by either or IFN-beta . Positive_regulation TNFSF10 IFNA2 20663526 2305195 did not *induce* changes in [TRAIL] or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation TNFSF10 IFNA21 17617740 1815958 *induces* [TRAIL] expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation TNFSF10 IFNA21 20663526 2305196 did not *induce* changes in [TRAIL] or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation TNFSF10 IFNA4 17617740 1815959 *induces* [TRAIL] expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation TNFSF10 IFNA4 20663526 2305197 did not *induce* changes in [TRAIL] or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation TNFSF10 IFNA5 17617740 1815960 *induces* [TRAIL] expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation TNFSF10 IFNA5 20663526 2305198 did not *induce* changes in [TRAIL] or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation TNFSF10 IFNA6 17617740 1815961 *induces* [TRAIL] expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation TNFSF10 IFNA6 20663526 2305199 did not *induce* changes in [TRAIL] or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation TNFSF10 IFNA7 17617740 1815962 *induces* [TRAIL] expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation TNFSF10 IFNA7 20663526 2305200 did not *induce* changes in [TRAIL] or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation TNFSF10 IFNA8 17617740 1815963 *induces* [TRAIL] expression and cell death via an IRF-1 dependent mechanism in human bladder cancer cells . Positive_regulation TNFSF10 IFNA8 20663526 2305201 did not *induce* changes in [TRAIL] or death receptor expression , or change other known mediators of the intrinsic and extrinsic apoptotic cascade in the cells . Positive_regulation TNFSF10 IFNB1 11410525 826445 Other sensitive melanoma cell lines had a similar *induction* of [TRAIL] . Positive_regulation TNFSF10 IFNB1 11410525 826446 In resistant A375 cells , did not *induce* [TRAIL/Apo2L] expression . Positive_regulation TNFSF10 IFNB1 11745330 888841 Antiviral response by natural killer cells through [TRAIL] gene *induction* by . Positive_regulation TNFSF10 IFNB1 11896621 922818 , but not gamma-irradiation , *induced* [TRAIL] in NIH-OVCAR-3 cells . Positive_regulation TNFSF10 IFNB1 12029096 968172 For example , A375 melanoma cells were defective in [TRAIL] *induction* by and were resistant to TRAIL induced apoptosis . Positive_regulation TNFSF10 IFNB1 14500361 1143869 Our results demonstrate that induction of apoptosis and the *induction* of proapoptotic mediator [TRAIL] is Stat1 dependent . Positive_regulation TNFSF10 IFNB1 14609566 1162497 , however , did not *cause* any upregulation of [TRAIL] in T cells . Positive_regulation TNFSF10 IFNB1 15922860 1413850 It was suggested that might *cause* apoptosis in DHL-4 cells through [TRAIL] . Positive_regulation TNFSF10 IFNB1 16320724 1487749 *Upregulation* of [TRAIL] expression on human T lymphocytes by and glatiramer acetate . Positive_regulation TNFSF10 IFNB1 16320724 1487750 In vitro *induced* [TRAIL] upregulation on anti-CD3 or phytohemagglutinin activated T cells was comparable for IFNbeta treated and non treated MS patients and controls , indicating that IFN receptors were neither saturated nor down-regulated by current IFNbeta therapy . Positive_regulation TNFSF10 IFNB1 16865278 1592761 *up-regulated* the expression of [TRAIL] , while NS-398 increased the expression of TRAIL receptors ( especially of death receptor 5 ) . Positive_regulation TNFSF10 IFNB1 17689283 1788328 A resistant melanoma cell line , A375 , lacked [APO2L/TRAIL] or apoptosis *induction* by either IFN-alpha2 or . Positive_regulation TNFSF10 IFNB1 17892398 1802557 [TRAIL] was not *induced* by in mutant cell lines U2A , U3A , U4A , U5A , and U6A , which lack , respectively , IFN regulatory factor-9 (IRF-9) , Stat1 , Jak1 , IFNAR-2 .2 , and Stat2 , indicating transcription factor IFN stimulated gene factor 3 (ISGF3) was essential for the induction of this gene . Positive_regulation TNFSF10 IFNB1 17892398 1802559 [TRAIL] was not *induced* by in U1A ( Tyk2 null ) or U1A . Positive_regulation TNFSF10 IFNB1 17892398 1802560 Biochemical and genetic analyses revealed the requirement of transcription factor NF-kappa B and phosphoinositide 3-kinase (PI3K) but not extracellular signal regulated kinase ( ERK ) for the *induction* of [TRAIL] by . Positive_regulation TNFSF10 IFNG 10395688 627526 We show that [TRAIL] is *inducible* by , by TNF-alpha , and by infection with human CMV , and has potent antiviral activity in vitro . Positive_regulation TNFSF10 IFNG 11315506 806414 *increased* the mRNA expression of Fas , [TRAIL] and caspase-1 , and surface Fas was also increased . Positive_regulation TNFSF10 IFNG 11410875 826508 *induces* cell death in human hepatoma cells through a [TRAIL/death] receptor mediated apoptotic pathway . Positive_regulation TNFSF10 IFNG 11410875 826511 In particular , potently *increased* the mRNA expression of [TRAIL] in both cell lines . Positive_regulation TNFSF10 IFNG 12615731 1065500 also *induces* [TRAIL] expression in NB cell lines . Positive_regulation TNFSF10 IFNG 14648593 1173435 AG490 , a JAK inhibitor , blocked [TRAIL] expression *induced* by . Positive_regulation TNFSF10 IFNG 14648593 1173436 SB203580 , a specific p38alpha and p38beta2 MAPK inhibitor , decreased the [TRAIL] expression *induced* by . Positive_regulation TNFSF10 IFNG 15241475 1274125 Promoter mapping , chromatin immunoprecipitation and RNA interference reveal that retinoid induced interferon regulatory factor-1 (IRF-1) , a tumor suppressor , is critically required for [TRAIL] *induction* by both RA and . Positive_regulation TNFSF10 IFNG 15511228 1328220 Western blotting analyses revealed that dramatically *increased* the protein levels of interferon regulatory factor (IRF)-1 , but not [TRAIL] receptors ( DR4 and DR5 ) and pro-apoptotic ( FADD and Bax ) and anti-apoptotic factors ( Bcl-2 , Bcl-XL , cIAP-1 , cIAP-2 and XIAP ) . Positive_regulation TNFSF10 IFNG 15536146 1367476 Although inducers of *stimulated* [TRAIL] expression on mature NK cells , our data indicated that constitutive TRAIL expression was a hallmark of immature cytotoxic NK cells . Positive_regulation TNFSF10 IFNG 15996036 1430137 These findings suggest that upregulation of [TRAIL] expression may be *induced* by virus antigen and inflammatory cytokine . Positive_regulation TNFSF10 IFNG 16762619 1572176 and TNF-alpha potently *induced* [TRAIL] in IEC . Positive_regulation TNFSF10 IFNG 16807984 1580435 In particular , *induced* the highest levels of [TRAIL] in cultured astrocytes . Positive_regulation TNFSF10 IFNG 18004565 1882801 *induced* [TRAIL] expression by DC and LC , and inhibition of TRAIL partially blocked cytotoxic effects . Positive_regulation TNFSF10 IFNG 19523671 2098475 The expressions of these chemokines , HLA-DR , [TRAIL] , and TNF receptor 2 were significantly *induced* by , whereas TRAIL receptor 4 was downregulated . Positive_regulation TNFSF10 IGF1R 24161672 2868208 In human gastric cancer MGC803 and BGC823 cells , [TRAIL] *induces* ( IGF-1R ) pathway activation . Positive_regulation TNFSF10 IKBKG 11557763 875285 As both TNF and PMA rapidly induce NF-kappaB activation this suggests that dependent activation of the NF-kappaB pathway is *necessary* but not sufficient for up-regulation of [TRAIL] in T cells . Positive_regulation TNFSF10 IL10 11695989 877171 These results indicate that the elevated expression of at the involution stage recruits lymphocytes and *induces* the expression of [TRAIL] and DR4 . Positive_regulation TNFSF10 IL12A 11774735 890599 Consisting with this finding , and NKT cell specific ligand , alpha-Galactosylceramide ( alpha-GalCer ) , *induced* TRAIL mediated cytotoxcity and anti-tumor effect , and which was mediated by [TRAIL] expressed on IFN-gamma activated NK cells . Positive_regulation TNFSF10 IL12A 18619507 1947384 Also , *augmented* the expression of cytotoxic effector molecules , [TRAIL] and perforin , and the phosphorylation of STAT1 , STAT4 , and ERK1/2 , which may also contribute to lysis by NK cells . Positive_regulation TNFSF10 IL12A 22520731 2602024 The treatment of glioblastoma multiforme through activation of microglia and [TRAIL] *induced* by rAAV2 mediated in a syngeneic rat model . Positive_regulation TNFSF10 IL12A 22980654 2674131 <[IL-12> *induced* expression of [TRAIL] enhances the cytotoxicity of NK cells against Jurkat cells ] . Positive_regulation TNFSF10 IL12A 22980654 2674133 *induced* expression of [TRAIL] on NK cells mediated the cytotoxicity to Jurkat cells . Positive_regulation TNFSF10 IL12B 11774735 890600 Consisting with this finding , and NKT cell specific ligand , alpha-Galactosylceramide ( alpha-GalCer ) , *induced* TRAIL mediated cytotoxcity and anti-tumor effect , and which was mediated by [TRAIL] expressed on IFN-gamma activated NK cells . Positive_regulation TNFSF10 IL12B 18619507 1947385 Also , *augmented* the expression of cytotoxic effector molecules , [TRAIL] and perforin , and the phosphorylation of STAT1 , STAT4 , and ERK1/2 , which may also contribute to lysis by NK cells . Positive_regulation TNFSF10 IL12B 22520731 2602025 The treatment of glioblastoma multiforme through activation of microglia and [TRAIL] *induced* by rAAV2 mediated in a syngeneic rat model . Positive_regulation TNFSF10 IL12B 22980654 2674132 <[IL-12> *induced* expression of [TRAIL] enhances the cytotoxicity of NK cells against Jurkat cells ] . Positive_regulation TNFSF10 IL12B 22980654 2674134 *induced* expression of [TRAIL] on NK cells mediated the cytotoxicity to Jurkat cells . Positive_regulation TNFSF10 IL15 18280748 1891332 Furthermore , *augmented* the expression of cytotoxic effector molecules ( [TRAIL] and Perforin ) and the phosphorylation of STAT1 and ERK1/2 , which may also contribute the NK lysis . Positive_regulation TNFSF10 IL17D 24155891 2859843 *enhances* the expression of [TRAIL] and TLR3 in human melanomas and inhibits their tumor growth in cooperation with a TLR3 agonist poly ( I:C ) partly in a TRAIL dependent manner . Positive_regulation TNFSF10 IL17D 24155891 2859844 We found that inhibits in vitro tumor growth of human melanomas and greatly *enhances* the expression of [TNF related apoptosis inducing ligand] ( TRAIL ) in a dose dependent manner . Positive_regulation TNFSF10 IL17D 24155891 2859845 In addition , and poly ( I:C ) cooperatively *augmented* [TRAIL] expression and inhibited tumor growth . Positive_regulation TNFSF10 IL17D 24155891 2859847 Taken together , these results suggest that *enhances* the expression of [TRAIL] and TLR3 in human melanomas and inhibits their tumor growth in cooperation with poly ( I:C ) , partly in a TRAIL dependent manner . Positive_regulation TNFSF10 IL18 10438925 635156 In contrast , [TRAIL] expression was not *induced* by , whereas it efficiently potentiated lymphokine activated killer activity of NK cells . Positive_regulation TNFSF10 IL2 10479402 643444 NK cells were shown to express surface [Apo-2L] in *response* to activation , and this response was restricted to the CD3 ( - ) population of the NK cells . Positive_regulation TNFSF10 IL2 10502402 648728 However , [TRAIL] mRNA expression was not *induced* by , suggesting that TRAIL gene induction is not coupled to the IL-2 receptor . Positive_regulation TNFSF10 IL2 14609566 1162495 In particular , not only but also LPS were able to induce secretion of soluble TRAIL , but did not *enhance* the expression of surface bound [TRAIL] . Positive_regulation TNFSF10 IL2 16440347 1521642 Stimulation with , significantly *up-regulated* the expression of [TRAIL] on liver NK cells , but this effect was barely observed on PB NK cells . Positive_regulation TNFSF10 IL2 22715591 2522788 The *upregulation* of [TNF related apoptosis inducing ligand] on NK cell by and suppression of regulatory T cells ( Tregs ) by IFN-alpha were recognized at the same time when cytotoxicity of peripheral blood mononuclear cells ( PBMCs ) was enhanced . Positive_regulation TNFSF10 IL6 10807904 736590 Moreover , in these cell lines secretion and NF-kappaB activation were *induced* by cross linked or non-cross linked [anti-TRAIL] , as well as by both receptor-specific IgGs . Positive_regulation TNFSF10 IL8 12874246 1115001 In surviving cells , [TRAIL] activates NF-kappaB , *induces* expression of E-selectin , ICAM-1 , and , and promotes adhesion of leukocytes . Positive_regulation TNFSF10 IL8 16751802 1645924 Here , we show that [TRAIL] strongly *induces* the expression of the proinflammatory cytokines and monocyte chemoattractant protein 1 and enhances the invasion of apoptosis-resistant pancreatic ductal adenocarcinoma cells in vitro by upregulation of the urokinase-type plasminogen activator expression . Positive_regulation TNFSF10 IL8 23392805 2739938 In PDAC cells , [TRAIL] strongly *induced* uPA and via TRAIL-R1 . Positive_regulation TNFSF10 IRF3 15994827 1429888 We show that is *involved* in the transcriptional induction of [TRAIL] , a key player in the apoptosis pathway . Positive_regulation TNFSF10 IRF3 15994827 1429891 *upregulates* [TRAIL] transcription following viral infection and binds an interferon stimulated response element in the TRAIL promoter . Positive_regulation TNFSF10 IRF9 19752753 2168280 In IFN-alpha treated OVCAR3 cells , IRF9-RNAi inhibited transcription of TRAIL whereas Stat1-RNAi did not , suggesting that the transcription of [TRAIL] induced by IFN-alpha predominantly *required* . Positive_regulation TNFSF10 ITIH4 15990565 1429553 Treatment of uninfected Jurkat T cells , as well as primary T cells with *results* in the upregulation of [TRAIL] death receptor expression and acquired sensitivity to TRAIL mediated cell death . Positive_regulation TNFSF10 ITIH4 18769477 1957309 Enhanced TRAIL sensitivity is due to [TRAIL] receptor up-regulation *induced* by . Positive_regulation TNFSF10 JUN 12807432 1101890 [TRAIL] rapidly ( from 20 min ) *induced* the phosphorylation of Akt and ERK , but not of . Positive_regulation TNFSF10 JUN 21654829 2442180 We recently identified [TNF related apoptosis inducing ligand] ( TRAIL ) and dependent *activation* of the pro-apoptotic Bcl-2 homolog Bim as an important apoptosis amplification pathway in hepatocytes . Positive_regulation TNFSF10 JUN 22895172 2672043 Induction of DR4 and DR5 was independent of p53 , Bax and Bim but was *dependent* on as JNK pharmacological inhibition and siRNA abolished the induction of the [TRAIL] receptors by MMC . Positive_regulation TNFSF10 JUN 23686163 2791840 Notch inhibition restores TRAIL mediated apoptosis via *dependent* upregulation of DR4 and DR5 [TRAIL] receptors in MDA-MB-231 breast cancer cells . Positive_regulation TNFSF10 KLRC1 24019170 2882399 *regulates* production of soluble [TRAIL] by ex vivo expanded human ?d T cells . Positive_regulation TNFSF10 LEP 23129404 2745284 At 100 ng/ml , *up-regulated* both NK cell granzyme B and [TRAIL] protein expressions and concomitantly down-regulated perforin expression without affecting Fas-L expression . Positive_regulation TNFSF10 MAP2K7 16099454 1460816 Finally , treatment with IFN-alpha *enhanced* the promoter activity of the [TRAIL] gene , which was partially abrogated by either JNK inhibitor or dnJNK1 , while it was moderately enhanced by . Positive_regulation TNFSF10 MAP3K7 20062539 2193814 To determine the *role* of in [TRAIL] signalling , we analyzed the effects of adding TRAIL to mouse embryonic fibroblasts ( MEFs ) derived from TAK1 conditional knockout mice . Positive_regulation TNFSF10 MAPK3 11278665 811102 Activation of the FasR , TNF-R1 , and [TRAIL-R] , respectively , rapidly *induced* subsequent activation , an event independent from caspase activity . Positive_regulation TNFSF10 MAPK3 15289937 1278540 Western blot analysis consistently showed that [TRAIL] *induced* a significant activation of , and a much weaker phosphorylation of Akt , while it did not affect the p38/MAPK pathway . Positive_regulation TNFSF10 MAPK3 20837473 2342409 ( but not p38 MAPK or JNK ) activation was also *required* for gossypol induced [TRAIL] receptor induction ; Positive_regulation TNFSF10 MAPK8 16099454 1460817 Finally , treatment with IFN-alpha *enhanced* the promoter activity of the [TRAIL] gene , which was partially abrogated by either JNK inhibitor or dnJNK1 , while it was moderately enhanced by . Positive_regulation TNFSF10 MATK 18955500 2014777 Together , our findings suggest that nuclear *activation* of by [TRAIL] acts as a positive feedback loop involving the mitochondrion dependent activation of caspases , independently of p53 . Positive_regulation TNFSF10 MCL1 15385934 1324183 [TRAIL/FP] *induced* no discernible changes in FLIP , DR4 , DR5 , , or survivin expression , modest declines in levels of DcR2 and c-IAP , but resulted in the marked transcriptional downregulation of XIAP . Positive_regulation TNFSF10 MCL1 17613437 1768782 [TRAIL] *induced* expression of antiapoptotic and cIAP2 through activation of NF-kappaB . Positive_regulation TNFSF10 MET 21706050 2538786 miR-130a targets and *induces* [TRAIL-sensitivity] in NSCLC by downregulating miR-221 and 222 . Positive_regulation TNFSF10 MMP2 20233617 2281595 In vitro *induced* the cleavage of recombinant [TRAIL] and inactivated its ability of inducing apoptosis . Positive_regulation TNFSF10 MMP7 18397859 1893685 The purpose of this study was to find out if [TRAIL] could *induce* the expression of uPA , IL-8 , and MMP-9 .and to explore the corresponding potential signaling transduction pathway in pancreatic cancer cells . Positive_regulation TNFSF10 MMP9 18834856 1981663 [TRAIL] *induces* expression via ERK activation in human astrocytoma cells . Positive_regulation TNFSF10 MMP9 18834856 1981665 We demonstrated that [TRAIL] *induces* expression in human astrocytoma cells , which is preceded by activation of extracellular signal regulated protein kinase ( ERK ) . Positive_regulation TNFSF10 MPO 16575489 1671872 To clarify the crucial role of PMN in ANCA associated vasculitis and the related mechanism , PMN was cultured with monoclonal antibody and PR3-ANCA to determine the function of phagocytosis , Interleukin- 8 (IL-8) production , glucose uptake , and TNF related apoptosis *induced* ligand ( [TRAIL] ) production . Positive_regulation TNFSF10 MYC 21514380 2423009 Up-regulation of DR5 [TRAIL] receptor and down-regulation of c-FLIP and the promotion of caspase dependent cell death , which contribute to TRAIL sensitization of MDR cells , were *regulated* by the over expressed in the MDR cells . Positive_regulation TNFSF10 MYLIP 21706050 2538785 targets MET and *induces* [TRAIL-sensitivity] in NSCLC by downregulating miR-221 and 222 . Positive_regulation TNFSF10 NAB2 23416169 2771087 Provided that TRAIL plays a key role in NK cell cytotoxicity towards infected and tumor cells , we investigated whether also *mediates* [TRAIL] expression in human NK cells , and if so through which mechanisms . Positive_regulation TNFSF10 NFATC1 21603612 2435903 Expression of *activated* [TRAIL] promoter activity and increased TRAIL mRNA and protein expression . Positive_regulation TNFSF10 NFKB1 10521444 652801 These findings suggest that [TRAIL] receptors *induce* apoptosis , and JNK activation through distinct signaling pathways , and activation of NF-kappaB is not sufficient for protecting cells from TRAIL induced apoptosis . Positive_regulation TNFSF10 NFKB1 10807904 736591 Moreover , in these cell lines interleukin-6 secretion and activation were *induced* by cross linked or non-cross linked [anti-TRAIL] , as well as by both receptor-specific IgGs . Positive_regulation TNFSF10 NFKB1 11313369 805404 The *role* of in [TNF related apoptosis inducing ligand] ( TRAIL ) -induced apoptosis of melanoma cells . Positive_regulation TNFSF10 NFKB1 11313369 805414 Therefore , these results suggest that *activation* of by [TRAIL] plays an important role in resistance of melanoma cells to TRAIL induced apoptosis and further suggest that inhibitors of NF-kappaB may be useful adjuncts in clinical use of TRAIL against melanoma . Positive_regulation TNFSF10 NFKB1 11464292 839431 Inhibition of protein kinase C by Gö6983 sensitized these cells to apoptotic challenges and strongly diminished *activation* of by anti-CD95 and [TRAIL] . Positive_regulation TNFSF10 NFKB1 11544302 855274 In this T cell model , as well as in primary T lymphocytes , expression of [TNF related apoptosis inducing ligand] ( TRAIL ) apoptotic signaling protein was dramatically *down-regulated* by inhibition of binding activity . Positive_regulation TNFSF10 NFKB1 12207174 983502 The role of [TRAIL] *induced* activation in epithelial cells is unknown . Positive_regulation TNFSF10 NFKB1 12885939 1116819 These findings demonstrate that is essential for monocytic maturation and is *activated* via distinct pathways , involving or not involving caspases , by the related cytokines [TRAIL] and TNF-alpha . Positive_regulation TNFSF10 NFKB1 15650163 1364016 Our results suggest that the constitutive activation of is *essential* for [Apo2L] gene induction and protection against Apo2L induced apoptosis and that suppression of NF-kappaB may be a useful adjunct in clinical use of Apo2L against ATL . Positive_regulation TNFSF10 NFKB1 15722197 1374640 The *activation* of and phosphatidylinositol-3 (PI3) kinase by TNF-alpha and [TRAIL] overrides the pro-apoptotic effects of these ligands in carcinoma cells and hinders their therapeutic application . Positive_regulation TNFSF10 NFKB1 16024612 1435235 Although [TRAIL] alone did not *induce* activity , TRAIL combined with z-VAD significantly increased NF-kappaB activation . Positive_regulation TNFSF10 NFKB1 16024612 1435244 These results suggest that [TRAIL] *induces* activation , but simultaneously abrogates NF-kappaB activation by cleaving p65 , and thereby inhibits the induction of anti-apoptotic proteins such as XIAP , which contributes to the strong apoptotic activity of TRAIL compared with other TNF family members . Positive_regulation TNFSF10 NFKB1 17070520 1649813 Furthermore , activation of cJun and suppression of by sodium arsenite *resulted* in upregulation of the endogenous [TRAIL] and downregulation of the cFLIP gene expression ( which encodes one of the main anti-apoptotic proteins in melanomas ) followed by cFLIP protein degradation and , finally , by acceleration of TRAIL induced apoptosis . Positive_regulation TNFSF10 NFKB1 18178561 1875738 [TRAIL-inducible] IGF1R expression *requires* activation . Positive_regulation TNFSF10 NFKB1 18834856 1981667 In addition , [TRAIL] *induces* the DNA binding activity of , an important transcription factor for MMP-9 induction . Positive_regulation TNFSF10 NFKB1 20150555 2227515 Furthermore , increased expression after injury *transactivated* the [TRAIL] promoter . Positive_regulation TNFSF10 NFKB1 20150555 2227521 We conclude that [TRAIL] induction *involves* FGF-2 , Sp1-phosphorylation and and that TRAIL promotes VSMC proliferation and neointima formation after arterial injury . Positive_regulation TNFSF10 NFKB1 20213318 2249201 Furthermore overexpression of the p65 subunit of *results* in an increase in [TRAIL] transcription and in apoptosis and deletion of IKKalpha and beta diminishes TRAIL expression and induction . Positive_regulation TNFSF10 NFKB1 20213318 2249206 We conclude that in Abelson cells , the inhibition of both and FoxO3a activity is *required* for suppression of [TRAIL] transcription and maintenance of the transformed state . Positive_regulation TNFSF10 NFKB1 9889416 558484 [TRAIL] *induces* apoptosis and activation of . Positive_regulation TNFSF10 NFKBIA 12807432 1101922 At later time points ( from 3 to 6 h onwards ) [TRAIL] *induced* a progressive degradation of inhibitor of kappaB (IkappaB)beta and IkappaBepsilon , but not , coupled to the nuclear translocation of NF-kappaB and an increase in its DNA binding activity . Positive_regulation TNFSF10 NFKBIB 12807432 1101923 At later time points ( from 3 to 6 h onwards ) [TRAIL] *induced* a progressive degradation of and IkappaBepsilon , but not IkappaBalpha , coupled to the nuclear translocation of NF-kappaB and an increase in its DNA binding activity . Positive_regulation TNFSF10 NFKBIE 12807432 1101924 At later time points ( from 3 to 6 h onwards ) [TRAIL] *induced* a progressive degradation of inhibitor of kappaB (IkappaB)beta and , but not IkappaBalpha , coupled to the nuclear translocation of NF-kappaB and an increase in its DNA binding activity . Positive_regulation TNFSF10 NOS2 21567079 2441237 Newcastle disease virus ( NDV ) is an interesting agent for activating innate immune activity in macrophages including secretion of TNF-a and IFN-a , upregulation of [TRAIL] and *activation* of NF-?B and . Positive_regulation TNFSF10 OXA1L 19481806 2091201 The accelerated thermal stability studies demonstrated that *promoted* the aggregation and degradation of native [TRAIL] , but not ST , and the addition of ZnSO ( 4 ) to the solution of native TRAIL with HSA partially inhibited its aggregation , suggesting ST is more difficult to lose its bound zinc ion than native TRAIL . Positive_regulation TNFSF10 PCBD1 10438545 634872 Despite the expression of TRAIL receptors death receptor 4 and death receptor 5 , purified [TRAIL] could not *induce* in any of the thyroid follicular cells examined . Positive_regulation TNFSF10 PDCD1 10960444 726364 Recombinant [TRAIL] *induced* extensive in cholangiocarcinoma cell lines lacking decoy receptor expression . Positive_regulation TNFSF10 PDCD1 12398939 1008985 [Apo2L/TRAIL] can selectively *induce* in transformed cells , although its wide tissue distribution suggests potential physiological roles . Positive_regulation TNFSF10 PDCD1 16251995 1525653 Using adenovirus ( Ad ) -mediated gene transfer , we overexpressed the proapoptotic molecules p53 , procaspase 3 , Bax , and [TRAIL] to *induce* therapeutic of residual lens cells to prevent PCO . Positive_regulation TNFSF10 PDCD10 10960444 726365 Recombinant [TRAIL] *induced* extensive in cholangiocarcinoma cell lines lacking decoy receptor expression . Positive_regulation TNFSF10 PDCD10 12398939 1008986 [Apo2L/TRAIL] can selectively *induce* in transformed cells , although its wide tissue distribution suggests potential physiological roles . Positive_regulation TNFSF10 PDCD10 16251995 1525654 Using adenovirus ( Ad ) -mediated gene transfer , we overexpressed the proapoptotic molecules p53 , procaspase 3 , Bax , and [TRAIL] to *induce* therapeutic of residual lens cells to prevent PCO . Positive_regulation TNFSF10 PDCD11 10960444 726363 Recombinant [TRAIL] *induced* extensive in cholangiocarcinoma cell lines lacking decoy receptor expression . Positive_regulation TNFSF10 PDCD11 12398939 1008984 [Apo2L/TRAIL] can selectively *induce* in transformed cells , although its wide tissue distribution suggests potential physiological roles . Positive_regulation TNFSF10 PDCD11 16251995 1525652 Using adenovirus ( Ad ) -mediated gene transfer , we overexpressed the proapoptotic molecules p53 , procaspase 3 , Bax , and [TRAIL] to *induce* therapeutic of residual lens cells to prevent PCO . Positive_regulation TNFSF10 PDCD2 10960444 726366 Recombinant [TRAIL] *induced* extensive in cholangiocarcinoma cell lines lacking decoy receptor expression . Positive_regulation TNFSF10 PDCD2 12398939 1008987 [Apo2L/TRAIL] can selectively *induce* in transformed cells , although its wide tissue distribution suggests potential physiological roles . Positive_regulation TNFSF10 PDCD2 16251995 1525655 Using adenovirus ( Ad ) -mediated gene transfer , we overexpressed the proapoptotic molecules p53 , procaspase 3 , Bax , and [TRAIL] to *induce* therapeutic of residual lens cells to prevent PCO . Positive_regulation TNFSF10 PDCD4 10960444 726367 Recombinant [TRAIL] *induced* extensive in cholangiocarcinoma cell lines lacking decoy receptor expression . Positive_regulation TNFSF10 PDCD4 12398939 1008988 [Apo2L/TRAIL] can selectively *induce* in transformed cells , although its wide tissue distribution suggests potential physiological roles . Positive_regulation TNFSF10 PDCD4 16251995 1525656 Using adenovirus ( Ad ) -mediated gene transfer , we overexpressed the proapoptotic molecules p53 , procaspase 3 , Bax , and [TRAIL] to *induce* therapeutic of residual lens cells to prevent PCO . Positive_regulation TNFSF10 PDCD5 10960444 726368 Recombinant [TRAIL] *induced* extensive in cholangiocarcinoma cell lines lacking decoy receptor expression . Positive_regulation TNFSF10 PDCD5 12398939 1008989 [Apo2L/TRAIL] can selectively *induce* in transformed cells , although its wide tissue distribution suggests potential physiological roles . Positive_regulation TNFSF10 PDCD5 16251995 1525657 Using adenovirus ( Ad ) -mediated gene transfer , we overexpressed the proapoptotic molecules p53 , procaspase 3 , Bax , and [TRAIL] to *induce* therapeutic of residual lens cells to prevent PCO . Positive_regulation TNFSF10 PDCD6 10960444 726369 Recombinant [TRAIL] *induced* extensive in cholangiocarcinoma cell lines lacking decoy receptor expression . Positive_regulation TNFSF10 PDCD6 12398939 1008990 [Apo2L/TRAIL] can selectively *induce* in transformed cells , although its wide tissue distribution suggests potential physiological roles . Positive_regulation TNFSF10 PDCD6 16251995 1525658 Using adenovirus ( Ad ) -mediated gene transfer , we overexpressed the proapoptotic molecules p53 , procaspase 3 , Bax , and [TRAIL] to *induce* therapeutic of residual lens cells to prevent PCO . Positive_regulation TNFSF10 PDCD7 10960444 726370 Recombinant [TRAIL] *induced* extensive in cholangiocarcinoma cell lines lacking decoy receptor expression . Positive_regulation TNFSF10 PDCD7 12398939 1008991 [Apo2L/TRAIL] can selectively *induce* in transformed cells , although its wide tissue distribution suggests potential physiological roles . Positive_regulation TNFSF10 PDCD7 16251995 1525659 Using adenovirus ( Ad ) -mediated gene transfer , we overexpressed the proapoptotic molecules p53 , procaspase 3 , Bax , and [TRAIL] to *induce* therapeutic of residual lens cells to prevent PCO . Positive_regulation TNFSF10 PDGFB 22415975 2612579 Taken together , our studies demonstrate for the first time that *induced* [TRAIL] transcriptional activity requires the cooperation of Sp1 , ac-H3 and p300 , mediating increased expression of TRAIL which is important for VSMC proliferation and migration . Positive_regulation TNFSF10 PI3 10502402 648724 The PKC inhibitors staurosporine and calphostin C , and the inhibitors wortmannin and LY294002 , also *prevented* [TRAIL] mRNA transcription by activated T cells , indicating a role for PKC and PI3-K . Positive_regulation TNFSF10 PIK3C3 15722197 1374641 The *activation* of NF-kappaB and by TNF-alpha and [TRAIL] overrides the pro-apoptotic effects of these ligands in carcinoma cells and hinders their therapeutic application . Positive_regulation TNFSF10 PIK3CA 10502402 648722 Murine [TRAIL] ( TNF related apoptosis inducing ligand ) expression induced by T cell activation is *blocked* by rapamycin , cyclosporin A , and inhibitors of , protein kinase C , and protein tyrosine kinases : evidence for TRAIL induction via the T cell receptor signaling pathway . Positive_regulation TNFSF10 PIK3CA 21472268 2361579 Our data demonstrated that the *activation* of and NF-?B by [TRAIL] is responsible for resistance to TRAIL in human gastric cancer cells . Positive_regulation TNFSF10 PIK3CA 22806638 2692056 Furthermore , signaling is *required* for NAB2 mediated [TRAIL] expression . Positive_regulation TNFSF10 PIK3R1 10502402 648723 Murine [TRAIL] ( TNF related apoptosis inducing ligand ) expression induced by T cell activation is *blocked* by rapamycin , cyclosporin A , and inhibitors of , protein kinase C , and protein tyrosine kinases : evidence for TRAIL induction via the T cell receptor signaling pathway . Positive_regulation TNFSF10 PIK3R1 21472268 2361580 Our data demonstrated that the *activation* of and NF-?B by [TRAIL] is responsible for resistance to TRAIL in human gastric cancer cells . Positive_regulation TNFSF10 PIK3R1 22806638 2692057 Furthermore , signaling is *required* for NAB2 mediated [TRAIL] expression . Positive_regulation TNFSF10 PIK3R4 15722197 1374642 The *activation* of NF-kappaB and by TNF-alpha and [TRAIL] overrides the pro-apoptotic effects of these ligands in carcinoma cells and hinders their therapeutic application . Positive_regulation TNFSF10 PLAU 18397859 1893686 The purpose of this study was to find out if [TRAIL] could *induce* the expression of , IL-8 , MMP-7 and MMP-9 .and to explore the corresponding potential signaling transduction pathway in pancreatic cancer cells . Positive_regulation TNFSF10 PLAU 23392805 2739939 In PDAC cells , [TRAIL] strongly *induced* and IL-8 via TRAIL-R1 . Positive_regulation TNFSF10 PRAME 23228130 2736619 *mediated* regulation of [TRAIL] : a new target for cancer therapy . Positive_regulation TNFSF10 PRTN3 16575489 1671873 To clarify the crucial role of PMN in ANCA associated vasculitis and the related mechanism , PMN was cultured with monoclonal antibody MPO-ANCA and to determine the function of phagocytosis , Interleukin- 8 (IL-8) production , glucose uptake , and TNF related apoptosis *induced* ligand ( [TRAIL] ) production . Positive_regulation TNFSF10 PTBP1 11035052 740867 Contrasting with our previous report using cultured splenic DCs , freshly isolated splenic killed YAC-1 cells using a Ca ( 2+ ) -independent mechanism , but this function did not appear *mediated* by Fas ligand , [TNF related apoptosis inducing ligand] , or TNF-alpha . Positive_regulation TNFSF10 PTBP2 11035052 740864 Contrasting with our previous report using cultured splenic DCs , freshly isolated splenic killed YAC-1 cells using a Ca ( 2+ ) -independent mechanism , but this function did not appear *mediated* by Fas ligand , [TNF related apoptosis inducing ligand] , or TNF-alpha . Positive_regulation TNFSF10 PTEN 12140294 985193 Similarly , overexpression of the tumor suppressor protein , an antagonist of PI 3-kinase signaling , *resulted* in the increased expression of [TRAIL] . Positive_regulation TNFSF10 PTEN 23419514 2759917 Moreover , RFP mediated ubiquitination of PTEN inhibits *dependent* activation of [TRAIL] expression and also suppresses its ability to induce apoptosis . Positive_regulation TNFSF10 PTH 16137047 1353321 down-regulated the expression of OPG but *up-regulated* the expressions of OPGL , M-CSF and [TRAIL] in HOBs . Positive_regulation TNFSF10 RELA 10521444 652802 These findings suggest that [TRAIL] receptors *induce* apoptosis , and JNK activation through distinct signaling pathways , and activation of NF-kappaB is not sufficient for protecting cells from TRAIL induced apoptosis . Positive_regulation TNFSF10 RELA 10807904 736592 Moreover , in these cell lines interleukin-6 secretion and activation were *induced* by cross linked or non-cross linked [anti-TRAIL] , as well as by both receptor-specific IgGs . Positive_regulation TNFSF10 RELA 11313369 805405 The *role* of in [TNF related apoptosis inducing ligand] ( TRAIL ) -induced apoptosis of melanoma cells . Positive_regulation TNFSF10 RELA 11313369 805415 Therefore , these results suggest that *activation* of by [TRAIL] plays an important role in resistance of melanoma cells to TRAIL induced apoptosis and further suggest that inhibitors of NF-kappaB may be useful adjuncts in clinical use of TRAIL against melanoma . Positive_regulation TNFSF10 RELA 11464292 839432 Inhibition of protein kinase C by Gö6983 sensitized these cells to apoptotic challenges and strongly diminished *activation* of by anti-CD95 and [TRAIL] . Positive_regulation TNFSF10 RELA 11544302 855275 In this T cell model , as well as in primary T lymphocytes , expression of [TNF related apoptosis inducing ligand] ( TRAIL ) apoptotic signaling protein was dramatically *down-regulated* by inhibition of binding activity . Positive_regulation TNFSF10 RELA 12207174 983503 The role of [TRAIL] *induced* activation in epithelial cells is unknown . Positive_regulation TNFSF10 RELA 12885939 1116820 These findings demonstrate that is essential for monocytic maturation and is *activated* via distinct pathways , involving or not involving caspases , by the related cytokines [TRAIL] and TNF-alpha . Positive_regulation TNFSF10 RELA 15650163 1364017 Our results suggest that the constitutive activation of is *essential* for [Apo2L] gene induction and protection against Apo2L induced apoptosis and that suppression of NF-kappaB may be a useful adjunct in clinical use of Apo2L against ATL . Positive_regulation TNFSF10 RELA 15722197 1374643 The *activation* of and phosphatidylinositol-3 (PI3) kinase by TNF-alpha and [TRAIL] overrides the pro-apoptotic effects of these ligands in carcinoma cells and hinders their therapeutic application . Positive_regulation TNFSF10 RELA 16024612 1435236 Although [TRAIL] alone did not *induce* activity , TRAIL combined with z-VAD significantly increased NF-kappaB activation . Positive_regulation TNFSF10 RELA 16024612 1435245 These results suggest that [TRAIL] *induces* activation , but simultaneously abrogates NF-kappaB activation by cleaving p65 , and thereby inhibits the induction of anti-apoptotic proteins such as XIAP , which contributes to the strong apoptotic activity of TRAIL compared with other TNF family members . Positive_regulation TNFSF10 RELA 17070520 1649814 Furthermore , activation of cJun and suppression of by sodium arsenite *resulted* in upregulation of the endogenous [TRAIL] and downregulation of the cFLIP gene expression ( which encodes one of the main anti-apoptotic proteins in melanomas ) followed by cFLIP protein degradation and , finally , by acceleration of TRAIL induced apoptosis . Positive_regulation TNFSF10 RELA 18178561 1875739 [TRAIL-inducible] IGF1R expression *requires* activation . Positive_regulation TNFSF10 RELA 18834856 1981668 In addition , [TRAIL] *induces* the DNA binding activity of , an important transcription factor for MMP-9 induction . Positive_regulation TNFSF10 RELA 20150555 2227516 Furthermore , increased expression after injury *transactivated* the [TRAIL] promoter . Positive_regulation TNFSF10 RELA 20150555 2227522 We conclude that [TRAIL] induction *involves* FGF-2 , Sp1-phosphorylation and and that TRAIL promotes VSMC proliferation and neointima formation after arterial injury . Positive_regulation TNFSF10 RELA 20213318 2249202 Furthermore overexpression of the p65 subunit of *results* in an increase in [TRAIL] transcription and in apoptosis and deletion of IKKalpha and beta diminishes TRAIL expression and induction . Positive_regulation TNFSF10 RELA 20213318 2249207 We conclude that in Abelson cells , the inhibition of both and FoxO3a activity is *required* for suppression of [TRAIL] transcription and maintenance of the transformed state . Positive_regulation TNFSF10 RELA 9889416 558485 [TRAIL] *induces* apoptosis and activation of . Positive_regulation TNFSF10 SELE 12874246 1114999 In surviving cells , [TRAIL] activates NF-kappaB , *induces* expression of , ICAM-1 , and IL-8 , and promotes adhesion of leukocytes . Positive_regulation TNFSF10 SERPINF1 21846721 2490680 *induced* tumor killing and [TRAIL] induction are abrogated by peroxisome proliferator activated receptor ? ( PPAR? ) antagonists or small interfering RNAs targeting PPAR? . Positive_regulation TNFSF10 SERPINF1 21846721 2490681 Furthermore , the activity of the [TRAIL] promoter in human macrophages is *increased* by stimulation . Positive_regulation TNFSF10 SETBP1 14560009 1154037 We demonstrate here that superantigen *induced* a dramatic upregulation of FasL , [TRAIL] , and TNF mRNA expression and function in IEC from BALB/c and C57BL/6 mice . Positive_regulation TNFSF10 SOCS3 21308719 2453068 Overexpression of *reduced* apoptosis in [TRAIL-] and resveratrol treated DU145 cells and SOCS-3 siRNA increased apoptosis in TRAIL treated PC-3 and LNCaP-IL-6+ cells . Positive_regulation TNFSF10 SP1 18701496 1950476 Taken together , our results indicate that induction of [TRAIL] by the combined treatments with MS275 and Adriamycin is *mediated* by and suggest that transcription factor Sp1 is an important target for the development of novel anticancer agents . Positive_regulation TNFSF10 SP1 20150555 2227513 Mutational studies confirmed a *role* for in injury- and FGF-2-inducible [TRAIL] transcription . Positive_regulation TNFSF10 SP1 20150555 2227520 We conclude that [TRAIL] induction *involves* FGF-2 , and NFkappaB and that TRAIL promotes VSMC proliferation and neointima formation after arterial injury . Positive_regulation TNFSF10 ST3GAL4 23638297 2779368 *increased* acquisition transfer latency ( TL1 ) and retention transfer latency ( [TL2] ) , and MDA , decreased transfer latency shortening ( TLs ) and TCA , produced hyperglycemia and hypoinsulinemia , and reduced the number of neurons in the hippocampus . Positive_regulation TNFSF10 STAT1 15970687 1446323 We and others have previously reported the *induction* of [TRAIL] is a crucial step in the IFN-beta induced apoptosis pathway . Positive_regulation TNFSF10 SYT1 16024612 1435240 Analysis of the NF-kappaB activation pathway indicated that [TRAIL] unexpectedly *induced* cleavage of at Asp97 , which was blocked by z-VAD , accounting for all of these findings . Positive_regulation TNFSF10 TAT 12767990 1094505 [TRAIL] secretion was *induced* by and by a cysteine-rich peptide of Tat but not by sulfhydryl modified Tat toxoid . Positive_regulation TNFSF10 TLR1 19769973 2195546 Inhibition of phosphoinositide 3 kinase with LY294002 blocked the up-regulation of PD-L1 by ligands and the TLR3-specific *induction* of [TRAIL] and type 1 IFNs . Positive_regulation TNFSF10 TLR10 19769973 2195554 Inhibition of phosphoinositide 3 kinase with LY294002 blocked the up-regulation of PD-L1 by ligands and the TLR3-specific *induction* of [TRAIL] and type 1 IFNs . Positive_regulation TNFSF10 TLR2 19769973 2195547 Inhibition of phosphoinositide 3 kinase with LY294002 blocked the up-regulation of PD-L1 by ligands and the TLR3-specific *induction* of [TRAIL] and type 1 IFNs . Positive_regulation TNFSF10 TLR3 19769973 2195548 Inhibition of phosphoinositide 3 kinase with LY294002 blocked the up-regulation of PD-L1 by TLR ligands and the *induction* of [TRAIL] and type 1 IFNs . Positive_regulation TNFSF10 TLR4 19769973 2195549 Inhibition of phosphoinositide 3 kinase with LY294002 blocked the up-regulation of PD-L1 by ligands and the TLR3-specific *induction* of [TRAIL] and type 1 IFNs . Positive_regulation TNFSF10 TLR5 19769973 2195550 Inhibition of phosphoinositide 3 kinase with LY294002 blocked the up-regulation of PD-L1 by ligands and the TLR3-specific *induction* of [TRAIL] and type 1 IFNs . Positive_regulation TNFSF10 TLR6 19769973 2195555 Inhibition of phosphoinositide 3 kinase with LY294002 blocked the up-regulation of PD-L1 by ligands and the TLR3-specific *induction* of [TRAIL] and type 1 IFNs . Positive_regulation TNFSF10 TLR7 19369481 2089021 Porcine NK cells express both and TLR8 mRNAs , and treatment with these TLR agonists *induced* higher mRNA expression levels of [TRAIL] and IL-15Ralpha , which may contribute to the activity of NK cells . Positive_regulation TNFSF10 TLR7 19769973 2195551 Inhibition of phosphoinositide 3 kinase with LY294002 blocked the up-regulation of PD-L1 by ligands and the TLR3-specific *induction* of [TRAIL] and type 1 IFNs . Positive_regulation TNFSF10 TLR8 19369481 2089022 Porcine NK cells express both TLR7 and mRNAs , and treatment with these TLR agonists *induced* higher mRNA expression levels of [TRAIL] and IL-15Ralpha , which may contribute to the activity of NK cells . Positive_regulation TNFSF10 TLR8 19769973 2195552 Inhibition of phosphoinositide 3 kinase with LY294002 blocked the up-regulation of PD-L1 by ligands and the TLR3-specific *induction* of [TRAIL] and type 1 IFNs . Positive_regulation TNFSF10 TLR9 19577819 2117566 In this study , we report that TLR7 and ligands can *induce* the secretion of biologically active [TNF related apoptosis inducing ligand] ( TRAIL ) by PDC . Positive_regulation TNFSF10 TLR9 19769973 2195553 Inhibition of phosphoinositide 3 kinase with LY294002 blocked the up-regulation of PD-L1 by ligands and the TLR3-specific *induction* of [TRAIL] and type 1 IFNs . Positive_regulation TNFSF10 TNF 10395688 627525 We show that [TRAIL] is *inducible* by IFN-gamma , by , and by infection with human CMV , and has potent antiviral activity in vitro . Positive_regulation TNFSF10 TNF 11557763 875281 We show that and phorbol 12-myristate 13-acetate ( PMA ) *induce* [TNF related apoptosis inducing ligand] ( TRAIL ) in T cells . Positive_regulation TNFSF10 TNF 11557763 875282 Inhibition of protein synthesis with cycloheximide blocked PMA , but not induced *up-regulation* of [TRAIL] . Positive_regulation TNFSF10 TNF 11859410 914808 Here we demonstrate that the death ligand [TRAIL] can *induce* apoptosis in primary , normal , thyroid epithelial cells under physiologically relevant conditions , specifically , treatment with the combination of inflammatory cytokines IL-1beta and . Positive_regulation TNFSF10 TNF 12010810 941314 in contrast , SN50 pretreatment sensitized MM cells to *induced* apoptosis and cleavage of caspase-8 and caspase-3 , similar to our previous finding of SN50 induced sensitization to apoptosis induced by the TNF-alpha family member TNF related apoptosis inducing ligand ( TRAIL ) [/Apo2L] . Positive_regulation TNFSF10 TNF 16762619 1572175 Interferon-gamma and potently *induced* [TRAIL] in IEC . Positive_regulation TNFSF10 TNF 17047073 1635883 Furthermore , we show that *induces* [TRAIL] through a transcriptional mechanism . Positive_regulation TNFSF10 TNF 17047073 1635884 Using reporter gene assays in conjunction with chromatin immunoprecipitation assays , we show that [TRAIL] *induction* by is regulated via both nuclear factor-kappaB and Sp1 binding sites . Positive_regulation TNFSF10 TNF 17047073 1635898 Collectively , our results suggest that *induction* of [TRAIL] by is critical for sensitization of breast cancer cells to chemotherapy . Positive_regulation TNFSF10 TNF 17989734 1889130 Although tumor necrosis factor (TNF) related apoptosis inducing ligand ( TRAIL ) and both activate NF-kappaB in human keratinocytes , only [TRAIL] potently *induces* apoptosis . Positive_regulation TNFSF10 TNF 19890995 2224781 [TRAIL] , *induced* by in BMC , triggered apoptosis of primary osteoblast only when TNFR1 signal was ablated in vitro . Positive_regulation TNFSF10 TNF 22301394 2570938 It was found that both CPT and *up-regulated* the expression of TRAIL receptor 1/2 but not [TRAIL] in HaCaT cells . Positive_regulation TNFSF10 TNFRSF10A 11494138 846151 Differential *activation* of and -2 by soluble and membrane [TRAIL] allows selective surface antigen directed activation of TRAIL-R2 by a soluble TRAIL derivative . Positive_regulation TNFSF10 TNFRSF10A 15389801 1354363 receptor (DR)4 and TRAIL-R2/DR5 are members of the tumor necrosis factor (TNF) receptor family , and can be *activated* by the [TRAIL] . Positive_regulation TNFSF10 TNFRSF10B 15389801 1354364 TRAIL-R1/death receptor (DR)4 and are members of the tumor necrosis factor (TNF) receptor family , and can be *activated* by the [TRAIL] . Positive_regulation TNFSF10 TNFRSF10B 19752753 2168283 Subsequently , TRAIL-R2-RNAi inhibited both antiproliferative activities of IFN-alpha and TRAIL , suggesting that *mediated* both IFN-alpha and [TRAIL] signals to elicit their antiproliferative activities . Positive_regulation TNFSF10 TNFRSF10D 17867593 1669099 In CM , [TGFbeta/IFNgamma/TRAIL] *induced* surface expression . Positive_regulation TNFSF10 TNFRSF11B 24247823 2892585 In diabetic nephropathy , the renal expression of TRAIL and is elevated , and in tubular cells proinflammatory cytokines *enhance* [TRAIL] expression . Positive_regulation TNFSF10 TNFRSF1A 17646260 1829648 *Activation* of or DR5 by TNF-alpha or [TRAIL] may regulate osteoblast connectivity , which is important to bone turnover . Positive_regulation TNFSF10 TNFRSF6B 15475369 1319206 Instead , in the *presence* of , [TRAIL] engagement resulted in an increased activation of caspase-8 , an elevated cleavage of Bid , and enhanced release of Smac and cytochrome c from mitochondria to cytosol compared with TRAIL alone . Positive_regulation TNFSF10 TNFSF10 12097384 961382 Interestingly , although the established T cell clones did not constitutively express detectable levels of , engagement of their TCR via activation with specific tumor cells selectively *induced* profound [APO2L/TRAIL] expression on the CD4 ( + ) , but not on the CD8 ( + ) , CTL clones . Positive_regulation TNFSF10 TNFSF12 22438963 2573483 Our experiments clearly demonstrate that does not *induce* the secretion of TNFa or [TRAIL] proteins . Positive_regulation TNFSF10 TP53 10933923 720349 Our results suggest a model in which the [TRAIL] decoy receptors may be *induced* by , thereby attenuating an apoptotic response that appears to involve KILLER/DR5 . Positive_regulation TNFSF10 TP53 14614322 1163620 In chemosensitive FL cells , we found that DNA damaging drugs promote apoptosis through *dependent* upregulation of the [TRAIL-DR5] receptor , resulting in activation of caspase-8 and downstream executioner caspases , thereby evading bcl-2 mediated suppression of apoptosis . Positive_regulation TNFSF10 TP53 19106633 2006832 *dependent* [TRAIL] induction in natural killer cells after chemotherapy exposure provides a link between the tumor suppressor p53 and the host immune response during cancer therapy as well as a paracrine mediated cell-extrinsic death response . Positive_regulation TNFSF10 TRA 11784850 901102 We demonstrate that DR5 ligation by either [TRAIL] or *induces* two functional outcomes , apoptosis and expression of the chemokine interleukin-8 (IL-8) ; Positive_regulation TNFSF10 VEGFA 15256058 1272051 However , the proangiogenic activity of [TRAIL] was not *mediated* by endogenous expression of . Positive_regulation TNFSF10 XIAP 20137126 2208045 [TRAIL] *induced* apoptosis in RPMI8226 cells , the expression level of genes bcl-2 , mcl-1 , CARP1 , CARP2 , and cFLIP decreased , while the expression level of Bax increased , but the expression level of caspase-3 and NF-kappaB P65 ( RelA ) proteins decreased . Positive_regulation TNFSF11 CD14 12958198 1138272 Our results demonstrate that [RANKL] *induces* the migration of MonoMac-6 monocytic cells as well as human freshly isolated total peripheral blood mononuclear cells ( PBMC ) and purified PBMC . Positive_regulation TNFSF11 EPHB2 12821717 1104222 These findings indicate that Cot/Tpl2 is essential for LPS induced activation and [RANKL] *induction* in osteoblasts . Positive_regulation TNFSF11 EPHB2 15334457 1291077 FGF-2 induced [RANKL] on RASFs and osteoclast formation were *suppressed* by an inhibitor of . Positive_regulation TNFSF11 EPHB2 15670856 1366006 Induction of TRANCE expression by IBMX was partially suppressed by the inhibitors of protein kinase A (PKA) , ERK , and p38 MAPK , suggesting that activation of and p38 MAPK , as well as PKA , is *involved* in [TRANCE] expression by IBMX . Positive_regulation TNFSF11 EPHB2 16827720 1586641 Our results indicate that EMD *induces* the formation of osteoclasts through interaction with [RANKL] , while and p38 MAPK may play a critical role in the enhancement of osteoclast formation in RAW 264.7 cells . Positive_regulation TNFSF11 EPHB2 17549607 1791973 The findings of this investigation suggested that activation of the and the PI3K/Akt pathways and inhibition of p38MAPK pathway were *involved* in [RANKL] expression induced by MIP-1alpha in bone-marrow stromal cells and osteoblasts . Positive_regulation TNFSF11 EPHB2 20337895 2266232 Inhibitors of and p38 MAP kinases , phosphoinositide 3-kinase and nuclear factor-kappaB *blocked* the effects of SP on [RANKL] expression in periodontal ligament cells . Positive_regulation TNFSF11 EPHB2 20506523 2307972 Taken together , these results suggest that the [RANKL] *acts* through , which in turn activates IKKalpha/beta and NF-kappaB , resulting in the activation of beta1 integrin and contributing to the migration of human chondrosarcoma cells . Positive_regulation TNFSF11 EPHB2 21328467 2394130 Taken together , these results suggest that the [RANKL] and RANK interaction *acts* through , which in turn activates NF-?B , resulting in the activation of ICAM-1 and contributing to the migration of human lung cancer cells . Positive_regulation TNFSF11 EPHB2 23246654 2737119 While ApoE did not affect the *activation* of , JNK , and p38 MAPK signaling pathways by [RANKL] , the phosphorylation of p65 trans-activation domain on serine 536 and transcription activity of NF-?B were reduced by ApoE overexpression . Positive_regulation TNFSF11 IL1B 10495128 647064 By northern analysis , ( 5 nmol/L ) and TNF-alpha ( 9 nmol/L ) *increased* OPG-L mRNA steady-state levels by up to two- to three-fold in normal marrow stromal cells ( MS ) , an immortalized marrow stromal cell line ( hMS ) , and the osteosarcoma cell line , MG-63 , whereas IL-6 ( 2 nmol/L , with or without its soluble receptor ) had no effect on [OPG-L] mRNA levels in any of these cells . Positive_regulation TNFSF11 IL1B 15068113 1232068 *stimulated* the expression of [RANKL] at messenger RNA ( mRNA ) and protein levels in HPDL cells . Positive_regulation TNFSF11 IL1B 15068113 1232069 Endogenous PGE2 partially mediated the *induced* [RANKL] mRNA expression . Positive_regulation TNFSF11 IL1B 15479886 1319909 In PHA prestimulated T cells or RA synovial T cells , IL18 , , or TNFalpha *increased* soluble [RANKL] production and membrane bound RANKL expression in a dose dependent manner . Positive_regulation TNFSF11 IL1B 16038916 1573707 The inhibitory effect of CTS on the induced *upregulation* of [RANKL] and RANK was sustained as well as magnitude and frequency dependent . Positive_regulation TNFSF11 IL1B 16636611 1562979 The expression of [RANKL] at mRNA and protein levels in HPDL cells was *stimulated* by . Positive_regulation TNFSF11 IL1B 16636611 1562980 Baicalin suppressed *induced* [RANKL] and COX-2 production at a concentration of 0.01 microg/ml . Positive_regulation TNFSF11 IL1B 17009257 1634045 In addition , interface membrane fibroblasts expressed [RANKL] and osteoprotegerin in *response* to stimulation with conditioned media , TNFalpha , or . Positive_regulation TNFSF11 IL1B 17032166 1630776 *induced* [RANKL] reporter expression was completely blocked with specific p38 inhibitors as well as dominant negative mutant constructs of MAPK kinase-3 and -6 . Positive_regulation TNFSF11 IL1B 17559635 1753255 *induced* [RANKL] expression at the mRNA and protein levels , as well as RANKL activity in human periodontal ligament cells . Positive_regulation TNFSF11 IL1B 17559635 1753270 Pretreatment with each MAPK inhibitor partially , but significantly , suppressed *induced* [RANKL] expression and its activity , as well as prostaglandin E2 production . Positive_regulation TNFSF11 IL1B 17586708 1764342 These findings indicate that is an autocrine factor regulating compressive force induced RANKL expression in PDL cells , and that intermittent force can effectively *induce* [RANKL] in PDL cells with less cell damage . Positive_regulation TNFSF11 IL1B 18786965 1976015 [RANKL] expression was *induced* by IL-6/sIL-6R ( but not IL-6 alone ) and by . Positive_regulation TNFSF11 IL1B 18786965 1976025 On the other hand , TNF-alpha and IL-17 did not *induce* [RANKL] expression , although TNF-alpha , IL-17 or stimulated cell growth and IL-6 production . Positive_regulation TNFSF11 IL1B 19762475 2163493 OPG and membranous [RANKL] levels were significantly *enhanced* by IL-1beta , TNF-alpha and PGE ( 2 ) , whereas membranous RANK was significantly increased only with . Positive_regulation TNFSF11 IL1B 20204061 2181003 OPG and [RANKL] expression *increased* with ; Positive_regulation TNFSF11 ITGB2 11167844 783040 These findings indicate that the persistent expression of CD11c and is not accounted for by RANKL being presented in a soluble form and that membrane bound [RANKL] is not *required* for the normal integrin expression in resorbing osteoclasts . Positive_regulation TNFSF11 JAG1 18710934 1968154 In the present study , we show that [RANKL] *induces* expression of and Notch2 in bone marrow macrophages during osteoclast differentiation . Positive_regulation TNFSF11 MAP2K6 17549607 1791979 The findings of this investigation suggested that activation of the and the PI3K/Akt pathways and inhibition of p38MAPK pathway were *involved* in [RANKL] expression induced by MIP-1alpha in bone-marrow stromal cells and osteoblasts . Positive_regulation TNFSF11 MAP2K6 20506523 2307978 Taken together , these results suggest that the [RANKL] *acts* through , which in turn activates IKKalpha/beta and NF-kappaB , resulting in the activation of beta1 integrin and contributing to the migration of human chondrosarcoma cells . Positive_regulation TNFSF11 MAP2K6 21328467 2394136 Taken together , these results suggest that the [RANKL] and RANK interaction *acts* through , which in turn activates NF-?B , resulting in the activation of ICAM-1 and contributing to the migration of human lung cancer cells . Positive_regulation TNFSF11 PTGER2 15068113 1232076 The PGE2 stimulated [RANKL] expression was *mediated* by and cAMP dependent PKA , while PKC was possibly involved in the PGE2 action . Positive_regulation TNFSF11 TLR7 17467812 1737448 Inhibition of TLR induced IL-1beta production , which partially reversed the upregulation of [RANKL] *induced* by ligands . Positive_regulation TNFSF11 TNF 10495128 647063 By northern analysis , IL-1beta ( 5 nmol/L ) and ( 9 nmol/L ) *increased* OPG-L mRNA steady-state levels by up to two- to three-fold in normal marrow stromal cells ( MS ) , an immortalized marrow stromal cell line ( hMS ) , and the osteosarcoma cell line , MG-63 , whereas IL-6 ( 2 nmol/L , with or without its soluble receptor ) had no effect on [OPG-L] mRNA levels in any of these cells . Positive_regulation TNFSF11 TNF 11500955 847163 [RANKL] increased the level of TNF-alpha mRNA and *induced* release from osteoclast progenitors . Positive_regulation TNFSF11 TNF 12611893 1085405 In the co-cultures CpG ODN induces [RANKL] expression in osteoblasts as a *result* of the more efficient induction . Positive_regulation TNFSF11 TNF 14969390 1209218 Although critical *roles* of in inflammatory arthritis and [RANKL] in bone resorption have been firmly established , a central controversy remains about the extent to which TNFalpha can compensate for RANKL during osteoclastogenesis and the stage at which RANK signaling is required for osteoclastogenesis . Positive_regulation TNFSF11 TNF 15020327 1221534 In animal studies , potently *increases* osteoclast formation in the presence of [RANKL] . Positive_regulation TNFSF11 TNF 15020327 1221539 potently *increased* osteoclast proliferation/differentiation in the presence of [RANKL] . Positive_regulation TNFSF11 TNF 15389885 1324291 Thus , we reasoned that may *regulate* [RANKL] and possibly RANK expression by stromal cells and osteoclast precursors ( OCPs ) , respectively . Positive_regulation TNFSF11 TNF 15479886 1319907 In PHA prestimulated T cells or RA synovial T cells , IL18 , IL1 beta , or *increased* soluble [RANKL] production and membrane bound RANKL expression in a dose dependent manner . Positive_regulation TNFSF11 TNF 15668736 1369642 These data suggest that *regulates* [RANKL] expression via IL-1 , and , therefore , IL-1 plays a role in TNF induced periarticular osteolysis . Positive_regulation TNFSF11 TNF 15979546 1424661 The increased osteoclastic activity in preeclampsia may be attributed to increased [RANKL] *induced* by increased interleukin-6 (IL-6) , , and transforming growth factor beta2 ( TGF-beta2 ) production . Positive_regulation TNFSF11 TNF 16200600 1463845 , produced by both BXD2 MSFs and BXD2 mouse macrophages , *had* a strong stimulatory effect on [RANKL] expression . Positive_regulation TNFSF11 TNF 16202028 1463903 *enhances* [RANKL] gene expression in vitro and it may be responsible for up-regulating RANKL in vivo . Positive_regulation TNFSF11 TNF 16734568 1566218 HPDL cells are capable of secreting M-CSF and expressing [RANKL] in *response* to . Positive_regulation TNFSF11 TNF 17009257 1634044 In addition , interface membrane fibroblasts expressed [RANKL] and osteoprotegerin in *response* to stimulation with conditioned media , , or IL-1beta . Positive_regulation TNFSF11 TNF 17032166 1630715 MKK3/6-p38 MAPK signaling is required for IL-1beta and *induced* [RANKL] expression in bone marrow stromal cells . Positive_regulation TNFSF11 TNF 17032166 1630746 Here , we report that IL-1beta and *induced* [RANKL] requires p38 mitogen activating protein kinase (MAPK) pathway activation for maximal expression . Positive_regulation TNFSF11 TNF 17032166 1630775 Real-time PCR was used to assess the p38 contribution toward IL-1beta and *induced* [RANKL] mRNA expression . Positive_regulation TNFSF11 TNF 17032166 1630777 Results from these studies indicate that p38 MAPK is a major signaling pathway involved in IL-1beta and *induced* [RANKL] expression in bone marrow stromal cells . Positive_regulation TNFSF11 TNF 17467668 1737371 These results indicate that is *induced* by [RANKL] in pOCs and serves as an autocrine factor promoting osteoclastogenesis through c-Fos and NFATc1 activation . Positive_regulation TNFSF11 TNF 17963332 1820262 In contrast , *increased* the expression of both OPG and [RANKL] in a time dependent manner . Positive_regulation TNFSF11 TNF 18786965 1976011 IL-6 trans signalling directly induces RANKL on fibroblast-like synovial cells and is involved in [RANKL] *induction* by and IL-17 . Positive_regulation TNFSF11 TNF 18786965 1976023 On the other hand , and IL-17 did not *induce* [RANKL] expression , although TNF-alpha , IL-17 or IL-1beta stimulated cell growth and IL-6 production . Positive_regulation TNFSF11 TNF 18786965 1976032 However , in the presence of sIL-6R , or IL-17 *induced* [RANKL] expression . Positive_regulation TNFSF11 TNF 18786965 1976039 IL-6/sIL-6R directly induced RANKL expression in RA-FLS and it is essential for [RANKL] *induction* by and IL-17 . Positive_regulation TNFSF11 TNF 19500694 2102960 The results showed that EM inhibited *induced* expressions of [RANKL] and NF-kappaB at both mRNA and protein levels in a concentration dependent manner . Positive_regulation TNFSF11 TNF 19762475 2163492 OPG and membranous [RANKL] levels were significantly *enhanced* by IL-1beta , and PGE ( 2 ) , whereas membranous RANK was significantly increased only with IL-1beta . Positive_regulation TNFSF11 TNF 20683884 2368082 In contrast , ADAM8 KO mice did not display a bone phenotype in vivo , but unlike WT littermates , they did not increase [RANKL] production , OCL formation , or calvarial fibrosis in *response* to in vivo . Positive_regulation TNFSF11 TNF 20890027 2326898 Especially , the increased production of IL-1 , IL-6 and could *induce* the expression of [RANKL] in bone tissues to enhance osteoclastogenesis . Positive_regulation TNFSF11 TNF 21963155 2507342 *increased* [RANKL] expression in primary human bone marrow adipocytes . Positive_regulation TNFSF11 TNF 22203215 2585896 The present data suggest that induces aberrant REG1a expression and that REG1a plays an important *role* in aberrant cell proliferation and [RANKL] expression of synovial fibroblasts , ultimately resulting in pannus formation . Positive_regulation TNFSF11 TNF 22298642 2570877 Our data demonstrate for the first time that the pressure overloaded myocardium generates [RANKL] , which *induces* , IL-1a , and IL-1ß production via a RANK-TRAF2/TRAF6-PLC-PKC-NF-?B mediated autocrine mechanism . Positive_regulation TNFSF11 TNF 22326262 2565514 Moreover , S1P enhanced [RANKL] expression *induced* by stimulation with in MH7A cells and CD4 ( + ) T cells . Positive_regulation TNFSF11 TNF 22776139 2659956 IL-4 also inhibited *induced* [RANKL] expression in the presence of TNF-a-responsive stromal cells in vivo . Positive_regulation TNFSF11 TNF 23843954 2816521 Carvedilol decrease IL-1ß and , *inhibits* MMP-2 , MMP-9 , COX-2 , and [RANKL] expression , and up-regulates OPG in a rat model of periodontitis . Positive_regulation TNFSF11 TNFSF10 17702740 1805998 also *prevented* OPG mediated inhibition of [RANKL] from binding RANK . Positive_regulation TNFSF12 EPHB2 23457623 2749547 Finally , western blot data revealed that [TWEAK] can *induce* phosphorylation of p38 , JNK and in HDMECs . Positive_regulation TNFSF12 TNF 21893119 2506440 Conversely , activation of caspase by exogenous *required* IL-13 , [TWEAK] , and Fn14 . Positive_regulation TNFSF12 TNFSF10 22438963 2573484 Our experiments clearly demonstrate that [TWEAK] does not *induce* the secretion of TNFa or proteins . Positive_regulation TNFSF13 EPHB2 21784102 2467477 This finding that activin A induces ERK and CREB phosphorylation suggests that and CREB *act* as intermediates in [APRIL] expression . Positive_regulation TNFSF13B EPHB2 18713867 1955645 It was also recently shown that [BAFF] *induces* sustained activation and increased turnover of the proapoptotic molecule Bim . Positive_regulation TNFSF13B TLR7 19201852 2033840 Although MDCs expressed higher levels of the known B cell growth factors IL-6 , IL-10 , and [B cell activating factor] in *response* to stimulation , they were unable to enhance B cell responses in this system . Positive_regulation TNFSF13B TLR7 21971969 2556932 this enhanced IgG4 production was associated with the *induction* of [BAFF] by NLR and ligands . Positive_regulation TNFSF13B TLR7 22652666 2610574 engagement *augments* [BAFF] mediated PS antibody responses and TLR ligands serve as adjuvants for induction of anti-PS antibodies either for pure PS or for PS-protein conjugate vaccines . Positive_regulation TNFSF13B TLR7 23636665 2805044 Furthermore , in MS-derived PBMCs , *mediated* production of IL-6 and the ex vivo expression of [B-cell activating factor] of the TNF family , two crucial cytokines for B-cell differentiation and survival , were induced by IFN-ß . Positive_regulation TNFSF13B TNF 17530706 1751413 Of the various cytokine stimuli , only *triggered* release of [BLyS] from the neutrophil membrane . Positive_regulation TNFSF13B TNF 17907168 1812671 In contrast to IFNgamma , neither , LPS , BLP , nor CpG *induced* the de novo synthesis and release of [BAFF] by FLS . Positive_regulation TNFSF13B TNF 18050196 1833222 To address the hypothesis that blockade can *result* in increased levels of interferon-alpha (IFNalpha) and [BAFF] , we quantified those mediators in plasma from etanercept- and placebo treated SS patients . Positive_regulation TNFSF13B TNF 18316202 1904266 Therefore , Dex is a potent inhibitor of constitutive and *induced* [BAFF] expression in FLS-RA . Positive_regulation TNFSF13B TNF 23684916 2811157 Our results demonstrate for the first time that VEGF mediated angiogenesis in RA could be controlled by *induced* [BAFF] expression through c-Fos . Positive_regulation TNFSF13B TNF 23684916 2811158 Data suggest that *induced* [BAFF] expression and BAFF mediated VEGF expression in synovium may cooperate to maintain the capacity of such cells to protect B cells from apoptosis and the supply of nutrients and oxygen in inflammatory microenvironments . Positive_regulation TNFSF15 TLR7 19637197 2124559 We have previously shown that [TL1A] is strongly *induced* by immune complexes ( IC ) but not ligands in antigen presenting cells . Positive_regulation TNFSF15 TNF 11911831 924247 Here we show that an endothelial cell derived TNF-like factor , [TL1A] , is a ligand for DR3 and decoy receptor TR6/DcR3 and that its expression is *inducible* by and IL-1alpha . Positive_regulation TNFSF15 TNF 24416448 2901140 [TL1A] *induces* TCR independent IL-6 and production and growth of PLZF? leukocytes . Positive_regulation TNFSF4 TNF 15696085 1372140 *increased* expression of both CD40 and [OX40 ligand] on both asthmatic and nonasthmatic airway smooth muscle cells . Positive_regulation TNFSF4 TNF 15696085 1372144 IL-1beta alone had no effect , but it attenuated the *induced* expression of both CD40 and [OX40 ligand] . Positive_regulation TNFSF4 TNF 19220210 2105895 In contrast , IFN-gamma reduced *induced* [OX40L] expression to a similar extent in both cell types . Positive_regulation TNIP2 TNF 25302363 2959336 In mice , ABIN-1 overexpression reduces allergic airway inflammation and *mediated* liver injury , [ABIN-2] overexpression delays liver regeneration , and ABIN-3 overexpression partially protects against LPS induced acute liver failure . Positive_regulation TNIP3 TNF 18081698 1882954 Expression of the NF-kappaB inhibitor [ABIN-3] in *response* to and toll-like receptor 4 stimulation is itself regulated by NF-kappaB . Positive_regulation TNIP3 TNF 25302363 2959337 In mice , ABIN-1 overexpression reduces allergic airway inflammation and *mediated* liver injury , ABIN-2 overexpression delays liver regeneration , and [ABIN-3] overexpression partially protects against LPS induced acute liver failure . Positive_regulation TNK2 TNFSF10 24085293 2867501 *triggered* a transient up-regulation of [Ack1] and its recruitment to lipid rafts along with TRAIL-R1/2 . Positive_regulation TNMD IL1B 15202019 1260937 We report for the first time that *induces* the expression of [TEM-8] in endothelial cells . Positive_regulation TNMD ITGAL 10556811 566008 The results indicate that : ( 1 ) GM-CSF can prime monocytes for increased TEM , ( 2 ) GM-CSF enhances *mediated* monocyte [TEM] and ( 3 ) this effect is in part mediated by increasing LFA-1 expression and activation . Positive_regulation TNMD ITGAL 11261794 794544 , but not VLA-4 , *mediated* blood T cell [TEM] to RANTES , macrophage inflammatory protein-1alpha ( MIP-1alpha ) , and stromal cell derived factor-1 (SDF-1) , and across tumor necrosis factor alpha (TNF-alpha) or interferon-gamma (IFN-gamma) -stimulated endothelial cells ( EC ) . Positive_regulation TNMD ITGAL 17038526 1692785 However , under shear stress , T cells encountering apically presented CXCL12 were primed to undergo robust *dependent* [TEM] toward subendothelial CCL5 . Positive_regulation TNMD ITGB2 11261794 794539 The *role* of and VLA-4 in chemokine induced T cell [transendothelial migration (TEM)] across cytokine activated endothelium has not been examined . Positive_regulation TNMD ITGB2 11261794 794548 Thus , *mediates* [TEM] under most conditions , but VLA-4 can also mediate TEM , although , in contrast to LFA-1 , this requires exogenous chemokines and EC activation . Positive_regulation TNMD ITGB2 17429072 1742363 Importantly , deletion of the ( 507 ) RKIKK ( 511 ) significantly delayed the *dependent* membrane projection and decreased leukocyte adhesion and subsequent [TEM] . Positive_regulation TNMD ITGB2 19307784 2052233 Blocking of CD18 , but not CD99 , decreased human PBMC adhesion on pEC , whereas blocking of or CD99 strongly *reduced* the subsequent human PBMC [TEM] across pEC . Positive_regulation TNMD ITGB2 9886254 584600 Addition of RGD peptides , fibronectin , fibrinogen , heparins , collagens alone or in combination , even to heparinase treated HUVEC , did not inhibit this *mediated* PMN [TEM] . Positive_regulation TNMD ITGB2 9886254 584602 The results indicate that : ( 1 ) *mediates* PMN [TEM] primarily by interaction with ICAM-1 and ICAM-2 ; Positive_regulation TNMD PECAM1 16440301 1540528 The antibody mediated blockade of these interactions *inhibits* [transendothelial migration (TEM)] of leukocytes and angiogenesis . Positive_regulation TNMD PECAM1 19342684 2056820 is *required* for leukocyte [transendothelial migration (TEM)] under most inflammatory conditions . Positive_regulation TNMD TNF 20308428 2230599 We find that depletion of p110alpha but not other p110 isoforms decreases *induced* endothelial permeability , Tyr phosphorylation of the adherens junction protein vascular endothelial cadherin ( VE-cadherin ) , and leukocyte [TEM] . Positive_regulation TNNI3 EDN2 12815045 1134362 In agreement with earlier work , *enhanced* both adult rat myocyte contractile performance and [cardiac troponin-I] phosphorylation . Positive_regulation TNNT2 AKT1 19801490 2164043 Inhibition of erbB2 , phosphoinositide 3-kinase (PI3K) , , and mTOR *blocked* the protective effects of NRG1 on cTnI and [cTnT] in NRVM . Positive_regulation TNNT2 AKT2 19801490 2164044 Inhibition of erbB2 , phosphoinositide 3-kinase (PI3K) , , and mTOR *blocked* the protective effects of NRG1 on cTnI and [cTnT] in NRVM . Positive_regulation TNNT2 AKT3 19801490 2164045 Inhibition of erbB2 , phosphoinositide 3-kinase (PI3K) , , and mTOR *blocked* the protective effects of NRG1 on cTnI and [cTnT] in NRVM . Positive_regulation TNNT2 ANGPT2 11446714 835401 *increased* the [CM-H2DCFDA] fluorescence signal , derived predominantly from H2O2 . Positive_regulation TNNT2 CAPN1 16981728 1617078 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Positive_regulation TNNT2 CAPN1 18823990 1981553 Additionally , by utilizing tachypaced human cTnT transfected HL-1 cardiomyocytes , we directly showed that the degradation of human [cTnT] was *mediated* by and not by caspases or proteasome . Positive_regulation TNNT2 CAPN10 16981728 1617079 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Positive_regulation TNNT2 CAPN10 18823990 1981554 Additionally , by utilizing tachypaced human cTnT transfected HL-1 cardiomyocytes , we directly showed that the degradation of human [cTnT] was *mediated* by and not by caspases or proteasome . Positive_regulation TNNT2 CAPN11 16981728 1617080 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Positive_regulation TNNT2 CAPN11 18823990 1981555 Additionally , by utilizing tachypaced human cTnT transfected HL-1 cardiomyocytes , we directly showed that the degradation of human [cTnT] was *mediated* by and not by caspases or proteasome . Positive_regulation TNNT2 CAPN12 16981728 1617077 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Positive_regulation TNNT2 CAPN12 18823990 1981552 Additionally , by utilizing tachypaced human cTnT transfected HL-1 cardiomyocytes , we directly showed that the degradation of human [cTnT] was *mediated* by and not by caspases or proteasome . Positive_regulation TNNT2 CAPN13 16981728 1617088 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Positive_regulation TNNT2 CAPN13 18823990 1981563 Additionally , by utilizing tachypaced human cTnT transfected HL-1 cardiomyocytes , we directly showed that the degradation of human [cTnT] was *mediated* by and not by caspases or proteasome . Positive_regulation TNNT2 CAPN14 16981728 1617089 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Positive_regulation TNNT2 CAPN14 18823990 1981564 Additionally , by utilizing tachypaced human cTnT transfected HL-1 cardiomyocytes , we directly showed that the degradation of human [cTnT] was *mediated* by and not by caspases or proteasome . Positive_regulation TNNT2 CAPN15 16981728 1617076 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Positive_regulation TNNT2 CAPN15 18823990 1981551 Additionally , by utilizing tachypaced human cTnT transfected HL-1 cardiomyocytes , we directly showed that the degradation of human [cTnT] was *mediated* by and not by caspases or proteasome . Positive_regulation TNNT2 CAPN2 16981728 1617081 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Positive_regulation TNNT2 CAPN2 18823990 1981556 Additionally , by utilizing tachypaced human cTnT transfected HL-1 cardiomyocytes , we directly showed that the degradation of human [cTnT] was *mediated* by and not by caspases or proteasome . Positive_regulation TNNT2 CAPN3 16981728 1617082 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Positive_regulation TNNT2 CAPN3 18823990 1981557 Additionally , by utilizing tachypaced human cTnT transfected HL-1 cardiomyocytes , we directly showed that the degradation of human [cTnT] was *mediated* by and not by caspases or proteasome . Positive_regulation TNNT2 CAPN5 16981728 1617083 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Positive_regulation TNNT2 CAPN5 18823990 1981558 Additionally , by utilizing tachypaced human cTnT transfected HL-1 cardiomyocytes , we directly showed that the degradation of human [cTnT] was *mediated* by and not by caspases or proteasome . Positive_regulation TNNT2 CAPN6 16981728 1617084 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Positive_regulation TNNT2 CAPN6 18823990 1981559 Additionally , by utilizing tachypaced human cTnT transfected HL-1 cardiomyocytes , we directly showed that the degradation of human [cTnT] was *mediated* by and not by caspases or proteasome . Positive_regulation TNNT2 CAPN7 16981728 1617085 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Positive_regulation TNNT2 CAPN7 18823990 1981560 Additionally , by utilizing tachypaced human cTnT transfected HL-1 cardiomyocytes , we directly showed that the degradation of human [cTnT] was *mediated* by and not by caspases or proteasome . Positive_regulation TNNT2 CAPN8 16981728 1617086 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Positive_regulation TNNT2 CAPN8 18823990 1981561 Additionally , by utilizing tachypaced human cTnT transfected HL-1 cardiomyocytes , we directly showed that the degradation of human [cTnT] was *mediated* by and not by caspases or proteasome . Positive_regulation TNNT2 CAPN9 16981728 1617087 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Positive_regulation TNNT2 CAPN9 18823990 1981562 Additionally , by utilizing tachypaced human cTnT transfected HL-1 cardiomyocytes , we directly showed that the degradation of human [cTnT] was *mediated* by and not by caspases or proteasome . Positive_regulation TNNT2 CISH 1993702 154191 Thus , additional and trans factors are *required* for transcription of the [cTNT] gene in myocardial cells which are not required for expression in skeletal muscle cells . Positive_regulation TNNT2 CRP 11017937 737643 Increased is an important prognostic indicator for early risk stratification in patients with an acute coronary syndrome (ACS) , independent of , and in combination with , *increased* [cardiac troponin T (cTnT)] . Positive_regulation TNNT2 GDF2 25108436 2954362 Western blotting was conducted to measure the expressions of myocardium specific proteins connexin 43 (CX43) , [cardiac troponin T (cTnT)] after three weeks *induced* by , and immunofluorescence to observe the positions of CX43 and cTnT in the cells . Positive_regulation TNNT2 MICE 23007142 2757274 Neither HIIE nor *caused* any significant arrhythmias or increased CRP , BNP , or [cTnT] . Positive_regulation TNNT2 MTOR 19801490 2164046 Inhibition of erbB2 , phosphoinositide 3-kinase (PI3K) , Akt , and *blocked* the protective effects of NRG1 on cTnI and [cTnT] in NRVM . Positive_regulation TNNT2 MYOCD 24744906 2936386 *induced* the expression of a-MHC , GATA4 , a-actinin , cardiac MHC , MYH11 , calponin , and SM a-actin , but not [cTnT] , ß-MHC , and MLC2v in iPSC-MSCs . Positive_regulation TNNT2 PLA2G15 23137500 2696625 Elevated [hs-cTnT] was more likely *due* to in the younger patients ( HR 1.4 , P = .001 ) and conversely more frequently due to non-ACS conditions in the elderly patients ( HR 1.3 , P = .0001 ) . Positive_regulation TNNT2 SMN1 18312428 1879143 Anti-FGF8b antibody inhibited the expression of SMA , [cTNT] , and Tbx5 , which are BMP independent heart mesoderm/early cardiomyocyte genes , but not Brachyury in cultured posterior blastoderm , and combined FGF8b and Nodal , but neither factor alone *induced* the expression of in association with heart specific markers in cultured epiblast . Positive_regulation TNNT2 SP1 16617124 1583001 Sp3 represses *mediated* transcriptional activation of the [cTnT] gene in embryonic cardiomyocytes . Positive_regulation TNNT2 SP1 16617124 1583002 Sp3 repression of *mediated* [cTnT] promoter activation is dose dependent , inferring a mechanism of competitive binding/inhibition . Positive_regulation TNP1 CCND1 15276080 1276785 We have found that [TNP-470] did not only *induce* p53 and p21 ( Cip1 ) but also in the basic fibroblast growth factors (bFGF) treated endothelial cells . Positive_regulation TNP2 CCND1 15276080 1276788 We have found that [TNP-470] did not only *induce* p53 and p21 ( Cip1 ) but also in the basic fibroblast growth factors (bFGF) treated endothelial cells . Positive_regulation TNPO1 TNF 10861785 705332 sICAM-1 and *induce* [MIP-2] with distinct kinetics in astrocytes and brain microvascular endothelial cells . Positive_regulation TNPO1 TNF 16856209 1607194 Neutrophil recruitment in immunized mice depends on [MIP-2] *inducing* the sequential release of MIP-1alpha , and LTB ( 4 ) . Positive_regulation TNS1 A2M 6085010 44462 It appears that [TNS] is a sensitive probe for monitoring protease induced but not methylamine *induced* conformational changes in bovine . Positive_regulation TNS1 CASP1 12646163 1069815 Therefore , *mediated* cleavage of [tensin] contributes to the disruption of actin organization and interrupts ECM mediated survival signals through phosphatidylinositol 3-kinase . Positive_regulation TNS1 CASP10 12646163 1069816 Therefore , *mediated* cleavage of [tensin] contributes to the disruption of actin organization and interrupts ECM mediated survival signals through phosphatidylinositol 3-kinase . Positive_regulation TNS1 CASP12 12646163 1069826 Therefore , *mediated* cleavage of [tensin] contributes to the disruption of actin organization and interrupts ECM mediated survival signals through phosphatidylinositol 3-kinase . Positive_regulation TNS1 CASP14 12646163 1069817 Therefore , *mediated* cleavage of [tensin] contributes to the disruption of actin organization and interrupts ECM mediated survival signals through phosphatidylinositol 3-kinase . Positive_regulation TNS1 CASP16 12646163 1069827 Therefore , *mediated* cleavage of [tensin] contributes to the disruption of actin organization and interrupts ECM mediated survival signals through phosphatidylinositol 3-kinase . Positive_regulation TNS1 CASP2 12646163 1069818 Therefore , *mediated* cleavage of [tensin] contributes to the disruption of actin organization and interrupts ECM mediated survival signals through phosphatidylinositol 3-kinase . Positive_regulation TNS1 CASP3 12646163 1069819 Therefore , *mediated* cleavage of [tensin] contributes to the disruption of actin organization and interrupts ECM mediated survival signals through phosphatidylinositol 3-kinase . Positive_regulation TNS1 CASP3 23953854 2836002 The endogenously produced NO inhibited macrophage proliferation , and induced apoptosis in concordance with the accumulation of p53 , phosphatase and [tensin] homologue deleted on chromosome 10 ( PTEN ) and DR5 , and the *activation* of , processes that were inhibited by N ( G ) -monomethyl-l-arginine , aminoguanidine ( NO synthase inhibitors ) and 2- ( 4-carboxyphenyl ) -4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide ( an NO scavenger ) . Positive_regulation TNS1 CASP4 12646163 1069820 Therefore , *mediated* cleavage of [tensin] contributes to the disruption of actin organization and interrupts ECM mediated survival signals through phosphatidylinositol 3-kinase . Positive_regulation TNS1 CASP5 12646163 1069821 Therefore , *mediated* cleavage of [tensin] contributes to the disruption of actin organization and interrupts ECM mediated survival signals through phosphatidylinositol 3-kinase . Positive_regulation TNS1 CASP6 12646163 1069822 Therefore , *mediated* cleavage of [tensin] contributes to the disruption of actin organization and interrupts ECM mediated survival signals through phosphatidylinositol 3-kinase . Positive_regulation TNS1 CASP7 12646163 1069823 Therefore , *mediated* cleavage of [tensin] contributes to the disruption of actin organization and interrupts ECM mediated survival signals through phosphatidylinositol 3-kinase . Positive_regulation TNS1 CASP8 12646163 1069824 Therefore , *mediated* cleavage of [tensin] contributes to the disruption of actin organization and interrupts ECM mediated survival signals through phosphatidylinositol 3-kinase . Positive_regulation TNS1 CASP9 12646163 1069825 Therefore , *mediated* cleavage of [tensin] contributes to the disruption of actin organization and interrupts ECM mediated survival signals through phosphatidylinositol 3-kinase . Positive_regulation TNS1 DLC1 22307599 2552225 Importantly , *activation* of by [tensin3] or its actin binding domain drastically reduced the anchorage independent growth of transformed cells . Positive_regulation TNS1 EGF 15140944 1247164 *induces* tyrosine phosphorylation of [tensin3] in MDA-MB-468 cells in a time- and dose dependent manner , but it is independent of an intact actin cytoskeleton or phosphatidylinositol 3-kinase . Positive_regulation TNS1 EGF 15140944 1247166 Activation of receptor is *necessary* but not sufficient for tyrosine phosphorylation of [tensin3] . Positive_regulation TNS1 ILK 15030759 1223165 The localization of [tensin] *requires* integrins , talin , and . Positive_regulation TNS1 ILK 21719054 2460940 *regulates* phosphatase and [tensin] homologue activity to promote tumorigenesis in neuroblastoma cells . Positive_regulation TNS1 MAPK1 20798394 2352069 Activation of p38 in cells by sorbitol induced hyperosmotic stress *increased* phosphorylation of [S-tag-tensin1] , which reduced binding to deleted in liver cancer-1 and increased binding to endogenous pTyr proteins , including p130Cas and focal adhesion kinase . Positive_regulation TNS1 MAPK10 20798394 2352070 Activation of p38 in cells by sorbitol induced hyperosmotic stress *increased* phosphorylation of [S-tag-tensin1] , which reduced binding to deleted in liver cancer-1 and increased binding to endogenous pTyr proteins , including p130Cas and focal adhesion kinase . Positive_regulation TNS1 MAPK11 20798394 2352071 Activation of p38 in cells by sorbitol induced hyperosmotic stress *increased* phosphorylation of [S-tag-tensin1] , which reduced binding to deleted in liver cancer-1 and increased binding to endogenous pTyr proteins , including p130Cas and focal adhesion kinase . Positive_regulation TNS1 MAPK12 20798394 2352072 Activation of p38 in cells by sorbitol induced hyperosmotic stress *increased* phosphorylation of [S-tag-tensin1] , which reduced binding to deleted in liver cancer-1 and increased binding to endogenous pTyr proteins , including p130Cas and focal adhesion kinase . Positive_regulation TNS1 MAPK13 20798394 2352073 Activation of p38 in cells by sorbitol induced hyperosmotic stress *increased* phosphorylation of [S-tag-tensin1] , which reduced binding to deleted in liver cancer-1 and increased binding to endogenous pTyr proteins , including p130Cas and focal adhesion kinase . Positive_regulation TNS1 MAPK14 20798394 2352074 Activation of p38 in cells by sorbitol induced hyperosmotic stress *increased* phosphorylation of [S-tag-tensin1] , which reduced binding to deleted in liver cancer-1 and increased binding to endogenous pTyr proteins , including p130Cas and focal adhesion kinase . Positive_regulation TNS1 MAPK15 20798394 2352068 Activation of p38 in cells by sorbitol induced hyperosmotic stress *increased* phosphorylation of [S-tag-tensin1] , which reduced binding to deleted in liver cancer-1 and increased binding to endogenous pTyr proteins , including p130Cas and focal adhesion kinase . Positive_regulation TNS1 MAPK3 20798394 2352075 Activation of p38 in cells by sorbitol induced hyperosmotic stress *increased* phosphorylation of [S-tag-tensin1] , which reduced binding to deleted in liver cancer-1 and increased binding to endogenous pTyr proteins , including p130Cas and focal adhesion kinase . Positive_regulation TNS1 MAPK4 20798394 2352076 Activation of p38 in cells by sorbitol induced hyperosmotic stress *increased* phosphorylation of [S-tag-tensin1] , which reduced binding to deleted in liver cancer-1 and increased binding to endogenous pTyr proteins , including p130Cas and focal adhesion kinase . Positive_regulation TNS1 MAPK6 20798394 2352077 Activation of p38 in cells by sorbitol induced hyperosmotic stress *increased* phosphorylation of [S-tag-tensin1] , which reduced binding to deleted in liver cancer-1 and increased binding to endogenous pTyr proteins , including p130Cas and focal adhesion kinase . Positive_regulation TNS1 MAPK7 20798394 2352078 Activation of p38 in cells by sorbitol induced hyperosmotic stress *increased* phosphorylation of [S-tag-tensin1] , which reduced binding to deleted in liver cancer-1 and increased binding to endogenous pTyr proteins , including p130Cas and focal adhesion kinase . Positive_regulation TNS1 MAPK8 20798394 2352079 Activation of p38 in cells by sorbitol induced hyperosmotic stress *increased* phosphorylation of [S-tag-tensin1] , which reduced binding to deleted in liver cancer-1 and increased binding to endogenous pTyr proteins , including p130Cas and focal adhesion kinase . Positive_regulation TNS1 MAPK9 20798394 2352080 Activation of p38 in cells by sorbitol induced hyperosmotic stress *increased* phosphorylation of [S-tag-tensin1] , which reduced binding to deleted in liver cancer-1 and increased binding to endogenous pTyr proteins , including p130Cas and focal adhesion kinase . Positive_regulation TNS1 NPY 9630349 512340 Accordingly , both [TNS-] and NA-induced contractions were not *potentiated* by in the presence of the TxA2 synthase inhibitor , UK 38485 ( 10 microM ) . Positive_regulation TNS1 PINK1 20517466 2271032 The NeuroD6 effect is not limited to the classic induction of the ROS scavenging enzymes , such as SOD2 ( superoxide dismutase 2 ) , GPx1 ( glutathione peroxidase 1 ) and PRDX5 ( peroxiredoxin 5 ) , but also to the recently identified powerful ROS suppressors PGC-1alpha , ( phosphatase and [tensin] homologue *induced* kinase 1 ) and SIRT1 . Positive_regulation TNS1 SIRT1 20517466 2271033 The NeuroD6 effect is not limited to the classic induction of the ROS scavenging enzymes , such as SOD2 ( superoxide dismutase 2 ) , GPx1 ( glutathione peroxidase 1 ) and PRDX5 ( peroxiredoxin 5 ) , but also to the recently identified powerful ROS suppressors PGC-1alpha , PINK1 ( phosphatase and [tensin] homologue *induced* kinase 1 ) and . Positive_regulation TNS1 SRC 7617039 315281 Regulation of cortactin and [tensin] hyperphosphorylation is *dependent* , whereas focal adhesion kinase and paxillin hyperphosphorylation is partly dependent on both Src and Fyn . Positive_regulation TNS1 STAT3 20215508 2223330 Tumor derived cell lines displayed higher migration , invasion , and metastatic ability and showed disrupted distribution of cell-cell junction markers mediated by *dependent* overexpression of the COOH terminal [tensin-like] ( Cten ) focal adhesion protein , which was also significantly upregulated in Stat3C mammary tumors . Positive_regulation TNS1 TLN1 15030759 1223163 The localization of [tensin] *requires* integrins , , and integrin linked kinase . Positive_regulation TNS1 TLN2 15030759 1223164 The localization of [tensin] *requires* integrins , , and integrin linked kinase . Positive_regulation TNS1 TNF 3131074 83444 Thus it appears that [TNS] contains another cytotoxic molecule and that itself may *act* indirectly in vivo , perhaps by activating an effector cell . Positive_regulation TNS1 TNF 3440028 83182 These results suggest that the differentiation activity of [TNS] is *due* to . Positive_regulation TOLLIP IL1B 16428431 1515887 [Tollip] therefore controls the magnitude of inflammatory cytokine production in *response* to and LPS . Positive_regulation TOLLIP TLR7 16239509 1471002 We also determined that MyD88 , IRAK , TRAF6 , and [Toll interacting protein (Tollip)] , but not TIRAP , were involved in the *mediated* response to P. aeruginosa in HAECs . Positive_regulation TOP1 EDN2 2176162 146933 Inhibition of mediated [topoisomerase I] *activation* by pertussis toxin . Positive_regulation TOP1 TNFSF10 11139287 762851 Topotecan , a novel [topoisomerase I] *inhibitor* , induced upregulation of TRAIL-R2 as well as downregulation of . Positive_regulation TOP1 TNFSF10 18556653 1946100 We also show that *induced* apoptotic [Top1cc] are preferentially formed by caspase-3 cleaved Top1 at sites of oxidative DNA lesions with an average of one apoptotic Top1cc/100 kbp . Positive_regulation TP53 ABCG2 19107196 2004134 The present work demonstrated that protects ES cells from PPIX accumulation during colony expansion , and that [p53] and gammaH2AX *acts* as a downstream checkpoint of ABCG2 dependent defense machinery in order to maintain the self-renewal of ES cells . Positive_regulation TP53 ARSA 14511359 1146593 Inhibited the activation of p42/p44 mitogen activated protein kinase (MAPK) by PD98059 , a specific inhibitor of extracellular regulatory kinase (ERK) , significantly decreased cell viability and enhanced the expression of [p53] *induced* by . Positive_regulation TP53 AXIN2 15526030 1335689 , but not AxindeltaHIPK2 , *activates* HIPK2 mediated [p53] phosphorylation at Ser 46 , facilitating p53 dependent transcriptional activity and apoptosis . Positive_regulation TP53 AXIN2 19513548 2092475 Silencing of *reduces* [p53] expression . Positive_regulation TP53 AXIN2 19731416 2134358 In cells treated with sublethal doses of ultra-violet ( UV ) radiation or doxorubicin ( Dox ) , Pirh2 abrogates *induced* [p53] phosphorylation at Ser 46 catalysed by HIPK2 , by competing with HIPK2 for binding to Axin . Positive_regulation TP53 AXIN2 19731416 2134372 An axin mutation promotes carcinogenesis in Axin ( Fu ) /+ ( Axin Fused ) mice , consistent with a dominantnegative *role* for ( Fu ) in [p53] activation . Positive_regulation TP53 AXIN2 21057547 2395613 Moreover , we found that dominant negative mutants of PML blocked AXIN induced [p53] activation , and that *promotes* PML sumoylation , a modification necessary for PML functions . Positive_regulation TP53 BPI 18451163 1902888 could thus *induce* a [p53-like] response even in the presence of mutant p53 . Positive_regulation TP53 CAPN8 19652454 2118992 Excitotoxicity associated [p53] expression in adult rat retina is *mediated* by activity but not by Cl- influx . Positive_regulation TP53 CAPN8 22117079 2548428 Here , we present evidence that CDDP promotes *mediated* PARC down-regulation , mitochondrial and nuclear [p53] accumulation , and apoptosis in chemosensitive but not resistant OVCA cells . Positive_regulation TP53 CAPN8 22751172 2670222 The direct way is the *upregulation* of [p53] by itself , since p53 is a substrate for it . Positive_regulation TP53 CCND1 7671232 322619 [p53] , through p21 ( WAF1/CIP1 ) , *induces* synthesis . Positive_regulation TP53 DAPK1 17339337 1720147 Evaluation of these calcium calmodulin kinase superfamily members as candidate Ser ( 20 ) kinases in vivo has shown that only CHK1 or can *stimulate* [p53] transactivation and induce Ser ( 20 ) phosphorylation of p53 . Positive_regulation TP53 EPHB2 11314025 806355 [p53] activation in response to microtubule disruption is *mediated* by signaling . Positive_regulation TP53 EPHB2 11532334 854047 These results suggest that *mediates* cisplatin induced [p53] activation to trigger apoptosis in B104 cells . Positive_regulation TP53 EPHB2 11761456 887749 Furthermore , we have demonstrated that cisplatin induced activation is *required* for optimal [p53] protein accumulation following cisplatin induced DNA damage . Positive_regulation TP53 EPHB2 12439598 1016862 Activation of is *required* for accumulation and phosphorylation of [p53] following cisplatin treatment . Positive_regulation TP53 EPHB2 15078887 1257706 Whereas the proportion of cells activating ERK versus p53 at 1 h depended on H ( 2 ) O ( 2 ) concentration , individual cells showed exclusively either [phospho-p53] formation or *activation* of and egr1 induction . Positive_regulation TP53 EPHB2 15899123 1408707 Phosphorylation of *resulted* in up-regulation of [p53] expression , which was blocked by mitogen activated protein kinase (MEK) , inhibitor PD 98059 . Positive_regulation TP53 EPHB2 17117479 1677406 In addition , we provide evidence that the signaling *regulates* Cyclin dependent kinase 5 (Cdk5) activity and stability of [tumor suppressor p53] . Positive_regulation TP53 EPHB2 18288380 1872678 Studies on the regulation of apoptosis showed that apicidin induces the up-regulation of [p53] and the downstream *activation* of in MCF10A-ras cells . Positive_regulation TP53 EPHB2 19183271 2043876 Furthermore , inhibition of *reduced* ONE induced phosphorylation of [p53] , a key modulator of the cellular stress response , and the proteolytic cleavage of poly ( ADP-ribose ) polymerase ( PARP ) , a hallmark of apoptosis . Positive_regulation TP53 EPHB2 19751709 2153236 We have previously shown that TCDD attenuates [p53] response by phosphorylating its regulator Mdm2 at Ser166 , and that can *mediate* this effect in hepatocytes . Positive_regulation TP53 EPHB2 20564491 2345354 Moreover , inhibition of by treatment of cells with the ERK-specific inhibitor PD98059 *blocked* WEGS mediated [p53] expression . Positive_regulation TP53 EPHB2 21078664 2371608 Overall , our results indicate that nimbolide can sensitize colon cancer cells to TRAIL induced apoptosis through three distinct mechanisms : reactive oxygen species- and *mediated* up-regulation of DR5 and DR4 , down-regulation of cell survival proteins , and up-regulation of [p53] and Bax . Positive_regulation TP53 EPHB2 21468663 2428116 Moreover , the pretreatment with trichostatin A ( TSA , a histone deacetylase inhibitor ) or TSA in combination with etoposide significantly sensitized HCC cells to apoptosis by inhibiting phosphorylation , reactivating caspases and PARP , and *inducing* translocation of [p53] and Bid to cytoplasm . Positive_regulation TP53 EPHB2 21660051 2475879 Intracellular zinc release activated *dependent* [GSK-3ß-p53] and Noxa-Mcl-1 signaling are both involved in cardiac ischemic-reperfusion injury . Positive_regulation TP53 EPHB2 21903092 2496639 In addition , knockdown of NAPA induced the activation of the MAPK kinases ERK , JNK and p38 , but only inhibition of *reduced* synoviolin ubiquitination and [p53] accumulation . Positive_regulation TP53 EPHB2 22466960 2583231 Interruption of ERK and p53 activities decreased SU11274 induced autophagy , and blocking of by the specific inhibitor PD98059 *suppressed* SU11274 induced [p53] activation . Positive_regulation TP53 EPHB2 22466960 2583235 Moreover , activation upregulated Beclin-1 expression through induction of Bcl-2 phosphorylation , but [p53] did not *induce* Bcl-2 phosphorylation . Positive_regulation TP53 EPHB2 23434831 2744446 Moreover , asperolide A significantly activated MAP kinases ( ERK1/2 , JNK and p38 MAP kinase ) by phosphorylation , and only the inhibition of activation by PD98059 reversed downregulation of G2/M regulatory proteins CDC2 , and *suppressed* upregulation of p21 and [p-p53] levels . Positive_regulation TP53 EPHB2 23859040 2817105 Exposure of SW480 cells to ECG also led to apoptosis as determined by time dependent changes in caspase-3 activity , MAPKs [ , p38 , and c-jun amino-terminal kinase ( JNK ) ] , p21 and [p53] *activation* , and AKT inhibition . Positive_regulation TP53 FAS 10352342 617282 Thus , wild-type [p53] *induces* BAK and expression in human glioma cells without enhancing their susceptibility to CD95 mediated apoptosis , and mutant p53 modulates CD95L evoked apoptotic signalling in a gain-of-function fashion up-stream and down-stream of caspase 3 activation . Positive_regulation TP53 FAS 10574967 569378 However , mutant [p53] without p53 peptide does not *induce* a activation or apoptosis . Positive_regulation TP53 FAS 10660538 664483 The functional conservation of p53 dependent Fas up-regulation argues strongly in favor of its biological importance and suggests that murine models may be used to study further the in vivo *role* of in the [p53] response . Positive_regulation TP53 FAS 14767544 1207629 In SK-Br3 cells , cerulenin induced inhibition of activity *resulted* in down-regulation of [p53] , and up-regulation of cyclin dependent kinase inhibitor (CDKi) p21WAF1/CIP1 . Positive_regulation TP53 FAS 23165211 2707619 Following cisplatin exposure , expression levels of [p53] *increased* , with a subsequent increase in MDM2 and p21 mRNA and protein levels and cell membrane levels . Positive_regulation TP53 FAS 9765154 537460 [p53] also *induced* binding and transiently sensitized cells to Fas induced apoptosis . Positive_regulation TP53 ID1 19079342 2030883 negatively *regulated* both [p53] and PTEN at the transcriptional level . Positive_regulation TP53 IL1B 18607537 1959551 *induced* both the IL-8 and p53 mRNA expression and protein production of IL-8 , but not [p53] . Positive_regulation TP53 JAG1 18757425 1956574 Conversely , forced expression of , activated NOTCH3 , or HEY1 *induced* [p53] and p21 ( WAF1/CIP1 ) . Positive_regulation TP53 LGALS7B 23967302 2832713 Expression of is *induced* in breast cancer cells by mutant [p53] . Positive_regulation TP53 MAP2K6 15899123 1408713 Phosphorylation of ERK resulted in up-regulation of [p53] expression , which was *blocked* by , inhibitor PD 98059 . Positive_regulation TP53 MAP2K6 21776823 2456898 Furthermore , inhibitor significantly *suppressed* metformin induced [p53] and Bax elevation while ERK inhibitor generated a slight reduction in p53 levels . Positive_regulation TP53 MAP2K6 21957016 2507310 We show that , in stem-like glioblastoma cells , MEK inhibition reduced MDM2 expression and that inhibition of either or MDM2 *resulted* in [p53] activation accompanied by p53 dependent downregulation of MGMT expression . Positive_regulation TP53 MAP2K6 22730327 2639099 We report here that delayed cell cycle progression , Ser-33 phosphorylation , and [p53] nuclear accumulation from SEPW1 depletion *require* 4 ( MKK4 ) . Positive_regulation TP53 MAP2K6 9765203 537536 Constitutive activation of ( a component of the MAPK cascade ) *induces* both [p53] and p16 , and is required for Ras induced senescence of normal human fibroblasts . Positive_regulation TP53 NES 10980695 731577 Recent reports indicate that the leucine-rich of HDM2 enables it to shuttle to the cytoplasm , and that this activity is *required* for degradation of [p53] . Positive_regulation TP53 NES 16007197 1459374 We show that [p53] efficiently drives the relocation of the chimeric reporter in response to irradiation and that this process *requires* the C-terminal . Positive_regulation TP53 NES 17371868 1734678 The cytoplasmic localization of mutant [p53s] *required* the C-terminal and an intact ubiquitination pathway . Positive_regulation TP53 NES 23562654 2783002 While high-content-analysis demonstrated that HDACi did not significantly induce caspase-3 or p21 activity , [p53-expression] was increased by VPA ( 3 mM , 5 mM ) at 48 h. HDACi-exposure *induced* mineralization per cell dose-dependently to a plateau level ( VPA-0.125 mM and TSA-25 nM ) with accompanying increases in mineralization/dentinogenic associated gene expression at 5 days ( DMP-1 , BMP-2/-4 , ) and 10 days ( DSPP , BMP-2/-4 ) . Positive_regulation TP53 NMNAT2 24552824 2924486 Furthermore , knockdown of NMNAT-2 significantly reduces cellular NAD ( + ) levels and protects cells from p53 dependent cell death upon DNA damage , suggesting an important functional *role* of in [p53] mediated signaling . Positive_regulation TP53 OSR1 14990790 1220398 HES1 , HEY1 , and TFAP4 , which are members of the basic helix-loop-helix transcription family , and were shown to *activate* [p53] through repression of HDM2 transcription . Positive_regulation TP53 PLAU 15937335 1434017 Single chain also *enhanced* [p53] expression to the same extent as intact two chain active uPA and the amino-terminal fragment . Positive_regulation TP53 PLAU 15937335 1434018 Pretreatment of cells with anti-beta1 integrin antibody blocked *induced* [p53] expression . Positive_regulation TP53 PLAU 15937335 1434019 *induced* [p53] expression occurs without increased p53 mRNA expression . Positive_regulation TP53 PLAU 15937335 1434022 *induced* [p53] expression does not require activation of tyrosine kinases . Positive_regulation TP53 PLAU 15937335 1434023 Inactivation of protein-tyrosine phosphatase SHP-2 inhibits both basal and *induced* [p53] expression . Positive_regulation TP53 PRODH 19654292 2119083 , catalyzing the first step in proline catabolism , is *induced* by [p53] and can regulate cell survival as well as mediate programmed cell death . Positive_regulation TP53 PTGER2 24145719 2902913 We report that signaling *triggers* increased [p53] gene transcriptional activity in AID ( + ) cycling blasts ( P < 0.01 ) . Positive_regulation TP53 RGS16 16405749 1513263 Wild type [p53] could *induce* mRNA expression , and RGS16 protein is related with carcinogenesis of glioma . Positive_regulation TP53 S100B 10490652 645614 Concerted regulation of wild-type [p53] nuclear accumulation and *activation* by and calcium dependent protein kinase C . Positive_regulation TP53 S100B 10490652 645615 We first confirmed that expression in mouse embryo fibroblasts *enhanced* specific nuclear accumulation of wild-type [p53] . Positive_regulation TP53 S100B 10876243 708885 A Ca2+ dependent conformational change in dimeric ( betabeta ) is *required* for it to bind [p53] and inhibit phosphorylation of this tumor suppressor in its C-terminal negative regulatory domain . Positive_regulation TP53 S100B 1454855 205562 Furthermore , and of particular interest , we have shown that purified [p53] undergoes temperature dependent oligomerization and that the interaction between and p53 not only *induces* total inhibition of p53 oligomerization but also promotes disassembly of the p53 oligomers . Positive_regulation TP53 S100B 19910580 2189352 These results suggest that interaction of RAGE and its ligand after myocardial infarction may play a role in myocyte apoptosis by *activating* ERK1/2 and [p53] signaling . Positive_regulation TP53 S100B 20351179 2255145 Such a function for S100B might also help to explain the rescue of nuclear translocation and *activation* of the temperature-sensitive [p53val135] mutant by at nonpermissive temperatures . Positive_regulation TP53 S100B 20672023 2298626 induces apoptosis by an extracellular mechanism via interaction with the receptor for advanced glycation end products and *activating* ERK1/2 and [p53] signaling . Positive_regulation TP53 SRGN 9627114 512002 Our data demonstrate that transcription is *induced* by [p53] during p53 dependent cell cycle arrest and apoptosis . Positive_regulation TP53 TFPI2 16598789 1604411 Inhibition of PP2A , but not , *mediates* [p53] activation by low levels of okadaic acid in rat liver epithelial cells . Positive_regulation TP53 TFPI2 16598789 1604412 siRNA mediated knockdown of PP2A , but not , also *increased* [p53] activity . Positive_regulation TP53 TNF 10416957 631451 In addition , it has been established that can *activate* the expression of wild type [p53] in concert with the nuclear transcription factor , NF-kappa B . Positive_regulation TP53 TNF 10428056 633102 [p53] *induction* by and involvement of p53 in cell death of human oligodendrocytes . Positive_regulation TP53 TNF 10880954 709216 When the responses of the tumour suppressors p53 and RB were analysed , it was found that and C8-ceramide *induced* increased expression of [p53] . Positive_regulation TP53 TNF 11391531 822937 Because [p53] is *up-regulated* by in an NF-kappaB dependent manner and the Mdr1b promoter contains a p53 binding site , we used liver cells expressing a dominant negative p53 to show that TNF-alpha up-regulation of Mdr1b is independent of functional p53 . Positive_regulation TP53 TNF 11865195 917918 Calpeptin suppresses *induced* death and accumulation of [p53] in L929 mouse sarcoma cells . Positive_regulation TP53 TNF 11865195 917919 In this report , we show a novel suppressive effect of calpeptin , a calpain inhibitor , on *induced* cell death and accumulation of [p53] in L929 mouse fibrosarcoma . Positive_regulation TP53 TNF 11865195 917920 Preincubation of cells with calpeptin blocked both *induced* cell death and accumulation of [p53] as examined with Western blot . Positive_regulation TP53 TNF 11865195 917921 *induced* accumulation of [p53] was in part contributed by increase of p53 mRNA level ( 2.2-fold ) in a calpeptin-insensitive manner . Positive_regulation TP53 TNF 11865195 917923 Taken together , our findings suggest that *induces* calpeptin dependent , but calpain independent accumulation of [p53] protein as a necessary step leading to death in L929 cells . Positive_regulation TP53 TNF 12036088 949076 also *increased* [p53] levels in the tissues ( 0.05 ng/mL ) compared with control cultures ( 0.03 ng/mL ; p = 0.02 ) . Positive_regulation TP53 TNF 12189181 979957 *potentiated* the cadmium induced accumulation of [p53] but did not affect expression levels of Bax , Mdm2 and p21 ( WAF/CIP ) . Positive_regulation TP53 TNF 12392301 1007697 *induced* accumulation of tumor suppressor protein [p53] and cyclin dependent protein kinase inhibitory protein p21 is inhibited by insulin in ME-180S cells . Positive_regulation TP53 TNF 12392301 1007699 Here we show that treatment of human cervical carcinoma cell line , ME-180S , with *results* in time dependent accumulation of [p53] and its transcriptional target , p21 . Positive_regulation TP53 TNF 12795334 1098413 Since many tumors secrete growth factor ( s ) that inhibit apoptosis and support the growth of cancer cells , we investigated the effects of human epidermal growth factor (EGF) on human mediated *induction* of [p53] and its transcriptional target , p21 in TNF-alpha sensitive human cervical carcinoma cell line , ME180S . Positive_regulation TP53 TNF 12795334 1098415 We found that can *increase* the cellular levels of [p53] , p21 and induce apoptosis in ME180S cells . Positive_regulation TP53 TNF 12795334 1098418 An inhibitor of PKC , GF 109203X inhibited EGF mediated suppression of *induced* accumulation of [p53] , p21 and induction of apoptosis . Positive_regulation TP53 TNF 12876306 1115364 Furthermore , the addition of AA to TNF-alpha treated proliferating endothelial cells blocked both the inhibition of retinoblastoma protein phosphorylation and enhanced [p53] expression *induced* by . Positive_regulation TP53 TNF 14612962 1163451 This study was carried out to determine if caused oxidative DNA damage in primary cultures of murine hepatocytes and whether any damage would *result* in the induction of the [tumor suppressor p53] and cell-cycle arrest . Positive_regulation TP53 TNF 16243830 1471166 Further investigation showed that silencing of hPEBP4 in MCF-7 cells promoted *induced* stability of p53 , up-regulation of [phospho-p53ser15] , p21waf/cip , and Bax , and down-regulation of Bcl-2 and Bcl-xL , which were shown to depend on extracellular signal regulated kinase 1/2 and c-jun NH2-terminal kinase activation by hPEBP4 silencing . Positive_regulation TP53 TNF 16978650 1633544 Peptide YY reverses *induced* transcription factor binding of interferon regulatory factor-1 and [p53] in pancreatic acinar cells . Positive_regulation TP53 TNF 16978650 1633554 We hypothesized that would *induce* IRF-1 and [p53] protein binding in pancreatic acinar cells and that PYY would attenuate the effect . Positive_regulation TP53 TNF 17567906 1763218 Functionally , transiently overexpressed Zfra sequestered NF-kappaB ( p65 ) , WOX1 , [p53] and phospho-ERK ( extracellular signal activated kinase ) in the cytoplasm , and or UV light could not effectively *induce* nuclear translocation of these proteins . Positive_regulation TP53 TNF 17567906 1763222 In *response* to , Zfra is upregulated and modulates TNF mediated cell death via interacting with TRADD , FADD and RIP ( death inducing signaling complex ) at the receptor level , and downstream effectors NF-kappaB , [p53] , WOX1 , and JNK1 . Positive_regulation TP53 TNF 18486908 1910949 All these results demonstrate that ursolic acid induce apoptosis via inhibition of NF-kappaB induced bcl-2 mediated anti-apoptotic pathway and subsequent activation of [p53] mediated and *induced* caspase-3 mediated pro-apoptotic pathways . Positive_regulation TP53 TNF 18796294 1976165 In addition , *induced* [p53] activation was reduced by ERK or JNK inhibition , but it was not affected by p38 inhibition . Positive_regulation TP53 TNF 18796294 1976169 In conclusion , these results demonstrate that *induced* MAPKs mediate [p53] activation in apoptotic and autophagic cell death , as well as autophagy may amplify apoptosis when associated with a death signaling pathway . Positive_regulation TP53 TNF 21312115 903722 Each pathway is triggered by a different stimulus : growth factor default , irradiation , *induction* of the [p53] oncosuppressor protein , glucocorticoid hormones ( in lymphocytes ) , ligand binding to Fas/APO ( CD95 ) , or , perforin secreted by cytotoxic T cells ( reviewed by Hale et al. [ 1 ] ) . Positive_regulation TP53 TNF 21541574 407723 We show in this report that at concentrations of 0.1 nM *induced* the DNA binding activity of wild-type [p53] fivefold in the H460a human lung carcinoma cell line . Positive_regulation TP53 TNF 21541574 407739 We conclude that can *activate* human wild-type [p53] in NSCLC cells by a post-translational mechanism . Positive_regulation TP53 TNF 22911714 2648570 Translocation of p53 to mitochondria was observed by Western Blot and co-immunoprecipitations showed that *induced* [p53] binding to GSK3ß and mitochondrial transcription factor A ( TFAM ) . Positive_regulation TP53 TNF 22911714 2648571 In addition , mitochondrial D-loop immunoprecipitation ( mtDIP ) revealed that *induced* [p53] binding to the regulatory D-loop region of mtDNA . Positive_regulation TP53 TNF 24242917 2910388 In serum starved quiescent IEC-6 cells , both AZD5438 and NU6140 decreased induced *activation* of [p53] and , consequently , rescued cells from apoptosis , indicating that sustained Cdk activity is required for apoptosis of quiescent cells . Positive_regulation TP53 TNF 7629160 316648 Taken together these results suggest that Rb , [p53] , and Cip1 ( p21 ) proteins mediate TNF-alpha antimitogenic activity , and *induces* growth arrest in the G1 phase in MCF-7 cells . Positive_regulation TP53 TNF 7649977 319160 Importantly , *induced* the association between [p53] and Sp1 in Jurkat T cells . Positive_regulation TP53 TNF 7760842 308027 Mutation of this sequence inhibited [p53] transactivation and *inducibility* of the human immunodeficiency virus type 1 long terminal repeat . Positive_regulation TP53 TNF 8051093 267604 Both p65 transactivation and *induction* of the [p53] promoter depended on an intact NF-kappa B site . Positive_regulation TP53 TNF 8166195 254836 *induced* a significant up-regulation of [p53] messenger ribonucleic acid levels in ovarian cancer cells grown in nude mice and in vitro , whereas interleukin-6 did not . Positive_regulation TP53 TNF 8166195 254838 *induced* up-regulation of [p53] tumor suppressor gene expression in epithelial ovarian cancer cell lines , together with the induction of cell death by apoptosis . Positive_regulation TP53 TNF 8559306 337256 The results of immunoblotting assay demonstrated that decreased the expression of mutant p53 protein but *induced* the expression of wild-type [p53] in C6 cells during apoptosis . Positive_regulation TP53 TNF 8867673 344813 In fact , only in the presence of Mg2+ , but not in the absence of divalent cations or in the presence of Ca2+ alone , *increased* p58c-fgr and [p53/56lyn] kinase activities ; Positive_regulation TP53 TNF 9478957 487038 *induced* changes in [p53] levels were detected 1 h after treatment , and peak levels were measurable 4-8 h after TNF exposure . Positive_regulation TP53 TNF 9737981 531658 By reverse transcription-polymerase chain reaction , we demonstrated that transiently *induces* the [tumor suppressor p53] in U937 cells . Positive_regulation TP53 TNF 9842892 552984 TNF induced enterocyte apoptosis in mice is mediated by the receptor 1 and does not *require* [p53] . Positive_regulation TP53 TNF 9842892 552985 *increased* the expression of [p53] tumor suppressor gene in the enterocytes from the crypts but not from the villi , as seen by Western blots and histochemistry . Positive_regulation TP53 TNF 9842892 552986 *increased* the expression of [p53] in both TNFR2-/- and TNFR1-/- mice . Positive_regulation TP53 TNFSF10 10933923 720350 Our results suggest a model in which the decoy receptors may be *induced* by [p53] , thereby attenuating an apoptotic response that appears to involve KILLER/DR5 . Positive_regulation TP53 TNFSF10 12189181 979960 In contrast , did not further *increase* the cadmium induced accumulation of [p53] despite its potentiation effects on the cadmium induced cell death . Positive_regulation TP53 TP63 10383130 624453 We found that trans *activated* the previously identified [p53] target genes , but the degree of the transactivation by p51/p63 differed from that by p53 . Positive_regulation TP53 TP63 11336476 812017 Transient co-transfection data indicate the possibility that DeltaNp73L can inhibit [p53-] , and more preferentially , mediated *transactivation* . Positive_regulation TP53 TP63 11423969 831103 We have found that and DeltaNp63alpha can differentially *regulate* endogenous [p53] target genes and induce cell cycle arrest and apoptosis . Positive_regulation TP53 TP63 11445003 834167 , a p53 related protein , has been shown to *activate* [p53-responsive] genes and induce apoptosis in certain cell types . Positive_regulation TP53 TP63 16337913 1491365 While both TAp63 and p53 induce similar apoptotic signaling proteins and require BAX expression and function for their effects , TAp63 induces neuronal death in the absence of p53 , but [p53] *requires* coincident expression for its proapoptotic actions . Positive_regulation TP53 TP63 16832836 1606464 Furthermore , *activated* several , but not all , [p53-inducible] genes , indicating that the mechanisms controlling p51- and p53 mediated tumor suppression differed . Positive_regulation TP53 TP63 18626511 1966563 Additionally , we observed a differential effect of p63 mutants on *mediated* induction of [p53/p63] and p63 specific target genes . Positive_regulation TP53BP2 TP63 24127607 2858997 Up-regulation of expression is *required* for [ASPP2] ( ?exon3/+ ) BALB/c mice to develop SCC , as heterozygosity of p63 but not p53 prevents them from developing it . Positive_regulation TP53I3 TP63 12374749 996670 Over expression of wild-type , but not deletion mutant , SSRP1 remarkably enhanced *dependent* luciferase activity , G1 arrest , apoptosis and expression of endogenous [PIG3] , p21 ( Waf1/cip1 ) and MDM2 in human p53-deficient lung carcinoma H1299 cells and mouse embryonic fibroblasts . Positive_regulation TP63 BMP4 12013553 941618 is *involved* in [cusp] formation in molar tooth germ of mice . Positive_regulation TP63 BMP4 12013553 941620 Our data thus suggest that is *involved* in [cusp] formation and differentiation of ameloblasts in the occlusal region of molars . Positive_regulation TP63 BMP7 16524929 1536128 We also demonstrate that BMP2 , and FGF10 are potent *inducers* of [p63] in cultured tissue explants . Positive_regulation TP63 CASP1 21248767 2402859 Moreover , the degradation of [p63] is *induced* by TRAIL elicited activation . Positive_regulation TP63 CASP10 21248767 2402860 Moreover , the degradation of [p63] is *induced* by TRAIL elicited activation . Positive_regulation TP63 CASP12 21248767 2402870 Moreover , the degradation of [p63] is *induced* by TRAIL elicited activation . Positive_regulation TP63 CASP14 21248767 2402861 Moreover , the degradation of [p63] is *induced* by TRAIL elicited activation . Positive_regulation TP63 CASP16 21248767 2402871 Moreover , the degradation of [p63] is *induced* by TRAIL elicited activation . Positive_regulation TP63 CASP2 21248767 2402862 Moreover , the degradation of [p63] is *induced* by TRAIL elicited activation . Positive_regulation TP63 CASP3 21248767 2402863 Moreover , the degradation of [p63] is *induced* by TRAIL elicited activation . Positive_regulation TP63 CASP4 21248767 2402864 Moreover , the degradation of [p63] is *induced* by TRAIL elicited activation . Positive_regulation TP63 CASP5 21248767 2402865 Moreover , the degradation of [p63] is *induced* by TRAIL elicited activation . Positive_regulation TP63 CASP6 21248767 2402866 Moreover , the degradation of [p63] is *induced* by TRAIL elicited activation . Positive_regulation TP63 CASP7 21248767 2402867 Moreover , the degradation of [p63] is *induced* by TRAIL elicited activation . Positive_regulation TP63 CASP8 21248767 2402868 Moreover , the degradation of [p63] is *induced* by TRAIL elicited activation . Positive_regulation TP63 CASP9 21248767 2402869 Moreover , the degradation of [p63] is *induced* by TRAIL elicited activation . Positive_regulation TP63 CD2 7693851 234244 Importantly , this *induced* tyrosine phosphorylation of [p63] can also occur in the absence of the CD3 zeta chain membrane expression , and is also distinct from the protein tyrosine kinases p56lck and p59fyn . Positive_regulation TP63 CD40 9464836 475882 *Induction* of interleukin-12 [p40] transcript by ligation via activation of nuclear factor-kappaB . Positive_regulation TP63 CD40LG 21832282 2485575 Moreover , *stimulated* [IL-12p40] and E-selectin expression markedly decreased after exposure to authentic peroxynitrite or cyclic stretch , respectively . Positive_regulation TP63 CDKN1A 10761704 683342 Ad-p73beta and [Ad-p51A] *induced* endogenous gene expression more effectively than Ad-p73alpha and Ad-p51B , respectively . Positive_regulation TP63 CDKN1C 17045206 1635699 Whereas p53 transactivates the retinoblastoma gene , [p63] and p73 *induce* the to maintain RB in an active , hypophosphorylated state . Positive_regulation TP63 CHUK 14960276 1208520 In Ikk alpha mutant mice and mice expressing a transdominant negative mutant of I kappa B alpha ( cI kappa B alpha Delta N ) , molars have abnormal cusps , indicating that is *involved* in [cusp] formation through the NF-kappa B pathway . Positive_regulation TP63 ETS1 19377509 2081917 Ets-1 p27 blocks p51 mediated transactivation of target genes and *induces* the translocation of Ets-1 [p51] from the nucleus to the cytoplasm . Positive_regulation TP63 FGF10 16524929 1536129 We also demonstrate that BMP2 , BMP7 and are potent *inducers* of [p63] in cultured tissue explants . Positive_regulation TP63 GAL 10671197 666679 Native *stimulated* IL-12 [p40] / p35 mRNA expression in a dose- and time dependent manner as measured by reverse transcriptase-PCR . Positive_regulation TP63 HGF 22521434 2607988 Using real-time RT-qPCR , Western blots , luciferase reporter assays , and siRNAs , as well as antibodies to specific signaling molecules we showed that *induced* VDR gene expression , as well as up-regulated [p63] gene expression . Positive_regulation TP63 IBD2 11515847 851137 The expression of IL-12 [p40] and its homologue , Epstein-Barr virus *induced* gene 3 , in . Positive_regulation TP63 IBD3 11515847 851133 The expression of IL-12 [p40] and its homologue , Epstein-Barr virus *induced* gene 3 , in . Positive_regulation TP63 IBD4 11515847 851138 The expression of IL-12 [p40] and its homologue , Epstein-Barr virus *induced* gene 3 , in . Positive_regulation TP63 IBD5 11515847 851139 The expression of IL-12 [p40] and its homologue , Epstein-Barr virus *induced* gene 3 , in . Positive_regulation TP63 IBD6 11515847 851140 The expression of IL-12 [p40] and its homologue , Epstein-Barr virus *induced* gene 3 , in . Positive_regulation TP63 IBD7 11515847 851134 The expression of IL-12 [p40] and its homologue , Epstein-Barr virus *induced* gene 3 , in . Positive_regulation TP63 IBD8 11515847 851135 The expression of IL-12 [p40] and its homologue , Epstein-Barr virus *induced* gene 3 , in . Positive_regulation TP63 IBD9 11515847 851136 The expression of IL-12 [p40] and its homologue , Epstein-Barr virus *induced* gene 3 , in . Positive_regulation TP63 IFIT3 1337288 207957 The p42MBPK , as well as the [p63] and p87 enzymes , are *stimulated* by transforming mutants but not normal c-src or nonmyristylated p60c-src . Positive_regulation TP63 IL12A 16249388 1518248 Hydrogen peroxide inhibits [p40] *induction* in macrophages by inhibiting c-rel translocation to the nucleus through activation of calmodulin protein . Positive_regulation TP63 IL12B 16249388 1518249 Hydrogen peroxide inhibits [p40] *induction* in macrophages by inhibiting c-rel translocation to the nucleus through activation of calmodulin protein . Positive_regulation TP63 IL16 19100623 2031200 IL-12 [p40] homodimer , but not IL-12 p70 , *induces* the expression of in microglia and macrophages . Positive_regulation TP63 IRF8 12876285 1142440 *Activation* of the murine interleukin-12 [p40] promoter by functional interactions between NFAT and . Positive_regulation TP63 ITCH 16861923 1613444 Here we show that , a HECT E3-ubiquitin ligase , *promotes* [p63] degradation . Positive_regulation TP63 ITCH 16908849 1608410 Here , we show that the Hect ( homologous to the E6-associated protein C terminus ) -containing Nedd4-like ubiquitin protein ligase binds , ubiquitylates , and *promotes* the degradation of [p63] . Positive_regulation TP63 MAFB 25005477 2948400 Functional analyses revealed that expression of [p63] and p73 , key components known to arrest the cell cycle , was directly *activated* by and cJun . Positive_regulation TP63 MDM2 11714701 896991 These data indicate that [p63] can be *activated* by under conditions in which p53 is inhibited . Positive_regulation TP63 NOTCH1 22291092 2560191 Subsequently , knockdown of Notch1 induced SST reversed *induced* decrease of BCL-2 and increase of [p63] , indicating that Notch1 induced tumor suppression may be partly through upregulating SST signaling . Positive_regulation TP63 NQO1 22249251 2681227 Previously , we have shown a *role* of cytosolic ( NQO1 ) in the stabilization of [p63] against 20S proteasomal degradation resulting in thinning of the epithelium and chemical induced skin cancer ( Oncogene ( 2011 ) 30 , 1098-1107 ) . Positive_regulation TP63 NQO1 22249251 2681229 Current studies have demonstrated that control of CCAAT-enhancer binding protein ( C/EBPa ) against 20S proteasomal degradation also *contributes* to the upregulation of [p63] expression and protection . Positive_regulation TP63 PDGFRA 15543606 1355246 signaling is *critical* for tooth [cusp] and palate morphogenesis . Positive_regulation TP63 PML 16007146 1465537 Here we present data indicating that ( i ) the physically interacts with p63 , ( ii ) p63 is localized into the PML nuclear-bodies (PML-NBs) in vivo , and ( iii ) PML *regulates* [p63] transcriptional activity . Positive_regulation TP63 PML 16007146 1465541 We show that the interaction of p63 with *increases* the levels of [p63] in cultured cells as well as its ability to transactivate the p53-responsive elements of the GADD45 , p21 and bax promoters . Positive_regulation TP63 POLD3 18787755 1976071 The low-virulent African swine fever virus ( ) *induces* enhanced expression and production of relevant regulatory cytokines ( IFNalpha , TNFalpha and [IL12p40] ) on porcine macrophages in comparison to the highly virulent ASFV/L60 . Positive_regulation TP63 SCGB1D4 23906066 2822512 Collectively , the present study reveals a critical role for *dependent* control of [p63] activity in coordination of ACD and stratification during epithelial morphogenesis . Positive_regulation TP63 SEC14L2 16331262 1539512 *regulates* expression of [DeltaN-p63] in a manner that is sensitive to p53 . Positive_regulation TP63 SETBP1 10675275 667704 Here we show that superantigen *induces* [IL-12/p40] secretion in macrophages . Positive_regulation TP63 SHH 17050669 1636131 In particular , [p63gamma] and p63beta ( both TA and DeltaN isoforms ) and TAp73beta isoform *induce* . Positive_regulation TP63 SHH 17786571 1848838 signaling is *critical* for cytodifferentiation and [cusp] formation in developing mouse molars . Positive_regulation TP63 SNAI2 20150431 2227507 These data suggest that the disruption of [p63] expression *induced* by Snail and plays a crucial role in tumor progression . Positive_regulation TP63 STAT3 10878010 722381 Unlike p94 ( fer ) , [p51] ( ferT ) did not *induce* the phosphorylation of but led to the phosphorylation of other nuclear proteins . Positive_regulation TP63 SWI5 8816483 384188 The transcription factor *regulates* expression of the cyclin kinase inhibitor [p40SIC1] . Positive_regulation TP63 TCF12 10861061 705223 An IFN-gamma-inducible , IFN consensus sequence binding protein ( ICSBP ) , *stimulates* IL-12 [p40] expression in macrophages . Positive_regulation TP63 TCF15 10861061 705224 An IFN-gamma-inducible , IFN consensus sequence binding protein ( ICSBP ) , *stimulates* IL-12 [p40] expression in macrophages . Positive_regulation TP63 TCF19 10861061 705225 An IFN-gamma-inducible , IFN consensus sequence binding protein ( ICSBP ) , *stimulates* IL-12 [p40] expression in macrophages . Positive_regulation TP63 TCF20 10861061 705226 An IFN-gamma-inducible , IFN consensus sequence binding protein ( ICSBP ) , *stimulates* IL-12 [p40] expression in macrophages . Positive_regulation TP63 TCF21 10861061 705227 An IFN-gamma-inducible , IFN consensus sequence binding protein ( ICSBP ) , *stimulates* IL-12 [p40] expression in macrophages . Positive_regulation TP63 TCF23 10861061 705231 An IFN-gamma-inducible , IFN consensus sequence binding protein ( ICSBP ) , *stimulates* IL-12 [p40] expression in macrophages . Positive_regulation TP63 TCF24 10861061 705233 An IFN-gamma-inducible , IFN consensus sequence binding protein ( ICSBP ) , *stimulates* IL-12 [p40] expression in macrophages . Positive_regulation TP63 TCF25 10861061 705232 An IFN-gamma-inducible , IFN consensus sequence binding protein ( ICSBP ) , *stimulates* IL-12 [p40] expression in macrophages . Positive_regulation TP63 TCF3 10861061 705228 An IFN-gamma-inducible , IFN consensus sequence binding protein ( ICSBP ) , *stimulates* IL-12 [p40] expression in macrophages . Positive_regulation TP63 TCF4 10861061 705229 An IFN-gamma-inducible , IFN consensus sequence binding protein ( ICSBP ) , *stimulates* IL-12 [p40] expression in macrophages . Positive_regulation TP63 TCF7 10861061 705230 An IFN-gamma-inducible , IFN consensus sequence binding protein ( ICSBP ) , *stimulates* IL-12 [p40] expression in macrophages . Positive_regulation TP63 TLR1 16413922 1514393 IkappaBNS-deficient macrophages and dendritic cells show increased *mediated* expression of genes such as IL-6 and [IL-12p40] , which are induced late after TLR stimulation . Positive_regulation TP63 TLR10 16413922 1514401 IkappaBNS-deficient macrophages and dendritic cells show increased *mediated* expression of genes such as IL-6 and [IL-12p40] , which are induced late after TLR stimulation . Positive_regulation TP63 TLR2 16413922 1514394 IkappaBNS-deficient macrophages and dendritic cells show increased *mediated* expression of genes such as IL-6 and [IL-12p40] , which are induced late after TLR stimulation . Positive_regulation TP63 TLR2 18778366 1980432 Leishmania donovani infection down-regulates *stimulated* [IL-12p40] and activates IL-10 in cells of macrophage/monocytic lineage by modulating MAPK pathways through a contact dependent mechanism . Positive_regulation TP63 TLR3 16413922 1514395 IkappaBNS-deficient macrophages and dendritic cells show increased *mediated* expression of genes such as IL-6 and [IL-12p40] , which are induced late after TLR stimulation . Positive_regulation TP63 TLR3 17805015 1791266 In vitro , ligation of significantly *increased* major histocompatibility complex and costimulatory molecule expression on adult microglia and induced high levels of interferon-alpha , [interleukin-12p40] , and interleukin-23 . Positive_regulation TP63 TLR4 16413922 1514396 IkappaBNS-deficient macrophages and dendritic cells show increased *mediated* expression of genes such as IL-6 and [IL-12p40] , which are induced late after TLR stimulation . Positive_regulation TP63 TLR5 16413922 1514397 IkappaBNS-deficient macrophages and dendritic cells show increased *mediated* expression of genes such as IL-6 and [IL-12p40] , which are induced late after TLR stimulation . Positive_regulation TP63 TLR6 16413922 1514402 IkappaBNS-deficient macrophages and dendritic cells show increased *mediated* expression of genes such as IL-6 and [IL-12p40] , which are induced late after TLR stimulation . Positive_regulation TP63 TLR7 16413922 1514398 IkappaBNS-deficient macrophages and dendritic cells show increased *mediated* expression of genes such as IL-6 and [IL-12p40] , which are induced late after TLR stimulation . Positive_regulation TP63 TLR8 16413922 1514399 IkappaBNS-deficient macrophages and dendritic cells show increased *mediated* expression of genes such as IL-6 and [IL-12p40] , which are induced late after TLR stimulation . Positive_regulation TP63 TLR9 16413922 1514400 IkappaBNS-deficient macrophages and dendritic cells show increased *mediated* expression of genes such as IL-6 and [IL-12p40] , which are induced late after TLR stimulation . Positive_regulation TP63 TMED7 19377509 2081916 Ets-1 blocks Ets-1 p51 mediated transactivation of target genes and *induces* the translocation of Ets-1 [p51] from the nucleus to the cytoplasm . Positive_regulation TP63 TP53 12944917 1136151 Accordingly , the 3 ' promoter of p73 , but not that of [p63] , was *activated* by in reporter assays . Positive_regulation TP63 TP53 16337913 1491368 While both TAp63 and p53 induce similar apoptotic signaling proteins and require BAX expression and function for their effects , TAp63 induces neuronal death in the absence of p53 , but *requires* coincident [p63] expression for its proapoptotic actions . Positive_regulation TP63 TP53 17045206 1635698 Whereas transactivates the retinoblastoma gene , [p63] and p73 *induce* the cyclin dependent kinase inhibitor p57 to maintain RB in an active , hypophosphorylated state . Positive_regulation TP63 TP53 21479434 2009829 No diffuse expression of [p63] was *detected* , although diffuse expression of was detected in 50.0 % ( 12/24 ) of the adenocarcinomas . Positive_regulation TP63 USO1 16337913 1491369 While both TAp63 and p53 induce similar apoptotic signaling proteins and require BAX expression and function for their effects , induces neuronal death in the absence of p53 , but p53 *requires* coincident [p63] expression for its proapoptotic actions . Positive_regulation TP63 VDR 17274004 1697403 In transfection experiments , the presence of the shorter *resulted* in higher NF-kappaB- and NFAT-driven transcription as well as higher [IL-12p40] promoter-driven transcription . Positive_regulation TP63 WNT1 22421361 2572856 Activation of canonical *led* to ectopic expression of a lymphoid enhancing factor and a T-cell factor ( LEF and TCF , respectively ) and absence of SRY (sex determining region Y)-box 2 ( SOX2 ) and tumor protein p63 ( [p63] ) expression in proximal derivatives . Positive_regulation TP63 WNT11 22421361 2572857 Activation of canonical *led* to ectopic expression of a lymphoid enhancing factor and a T-cell factor ( LEF and TCF , respectively ) and absence of SRY (sex determining region Y)-box 2 ( SOX2 ) and tumor protein p63 ( [p63] ) expression in proximal derivatives . Positive_regulation TP63 WNT16 22421361 2572862 Activation of canonical *led* to ectopic expression of a lymphoid enhancing factor and a T-cell factor ( LEF and TCF , respectively ) and absence of SRY (sex determining region Y)-box 2 ( SOX2 ) and tumor protein p63 ( [p63] ) expression in proximal derivatives . Positive_regulation TP63 WNT2 22421361 2572858 Activation of canonical *led* to ectopic expression of a lymphoid enhancing factor and a T-cell factor ( LEF and TCF , respectively ) and absence of SRY (sex determining region Y)-box 2 ( SOX2 ) and tumor protein p63 ( [p63] ) expression in proximal derivatives . Positive_regulation TP63 WNT3 22421361 2572859 Activation of canonical *led* to ectopic expression of a lymphoid enhancing factor and a T-cell factor ( LEF and TCF , respectively ) and absence of SRY (sex determining region Y)-box 2 ( SOX2 ) and tumor protein p63 ( [p63] ) expression in proximal derivatives . Positive_regulation TP63 WNT4 22421361 2572860 Activation of canonical *led* to ectopic expression of a lymphoid enhancing factor and a T-cell factor ( LEF and TCF , respectively ) and absence of SRY (sex determining region Y)-box 2 ( SOX2 ) and tumor protein p63 ( [p63] ) expression in proximal derivatives . Positive_regulation TP63 WNT6 22421361 2572861 Activation of canonical *led* to ectopic expression of a lymphoid enhancing factor and a T-cell factor ( LEF and TCF , respectively ) and absence of SRY (sex determining region Y)-box 2 ( SOX2 ) and tumor protein p63 ( [p63] ) expression in proximal derivatives . Positive_regulation TPM1 EPHB2 17895359 1811271 We identified , for the first time , death associated protein kinase 1 ( DAP kinase 1 ) as the kinase that phosphorylates [tropomyosin-1] in *response* to activation by hydrogen peroxide ( H ( 2 ) O ( 2 ) ) . Positive_regulation TPM1 TMOD1 3595858 75509 Since the regulation of smooth muscle contraction by caldesmon *requires* the presence of [tropomyosin] , these results suggest that the direct interaction between tropomyosin and caldesmon on the thin filament plays a role in this regulation . Positive_regulation TPM1 TMOD1 7730404 302310 Mechanisms of thin filament assembly in embryonic chick cardiac myocytes : *requires* [tropomyosin] for assembly . Positive_regulation TPM1 TMOD1 9210222 441189 Unlike proteins that cap actin filament barbed ends , also binds tropomyosin and *requires* [tropomyosin] for tight capping of actin filament pointed ends . Positive_regulation TPM2 TMOD1 3595858 75513 Since the regulation of smooth muscle contraction by caldesmon *requires* the presence of [tropomyosin] , these results suggest that the direct interaction between tropomyosin and caldesmon on the thin filament plays a role in this regulation . Positive_regulation TPM2 TMOD1 7730404 302314 Mechanisms of thin filament assembly in embryonic chick cardiac myocytes : *requires* [tropomyosin] for assembly . Positive_regulation TPM2 TMOD1 9210222 441193 Unlike proteins that cap actin filament barbed ends , also binds tropomyosin and *requires* [tropomyosin] for tight capping of actin filament pointed ends . Positive_regulation TPM3 TMOD1 3595858 75517 Since the regulation of smooth muscle contraction by caldesmon *requires* the presence of [tropomyosin] , these results suggest that the direct interaction between tropomyosin and caldesmon on the thin filament plays a role in this regulation . Positive_regulation TPM3 TMOD1 7730404 302318 Mechanisms of thin filament assembly in embryonic chick cardiac myocytes : *requires* [tropomyosin] for assembly . Positive_regulation TPM3 TMOD1 9210222 441197 Unlike proteins that cap actin filament barbed ends , also binds tropomyosin and *requires* [tropomyosin] for tight capping of actin filament pointed ends . Positive_regulation TPM4 TMOD1 3595858 75521 Since the regulation of smooth muscle contraction by caldesmon *requires* the presence of [tropomyosin] , these results suggest that the direct interaction between tropomyosin and caldesmon on the thin filament plays a role in this regulation . Positive_regulation TPM4 TMOD1 7730404 302322 Mechanisms of thin filament assembly in embryonic chick cardiac myocytes : *requires* [tropomyosin] for assembly . Positive_regulation TPM4 TMOD1 9210222 441201 Unlike proteins that cap actin filament barbed ends , also binds tropomyosin and *requires* [tropomyosin] for tight capping of actin filament pointed ends . Positive_regulation TPO EPHB2 11535599 868944 One known pathway by which [TPO] *induces* activation is through the association of Shc with the penultimate phosphotyrosine within the TPO receptor , Mpl . Positive_regulation TPO EPHB2 21970435 2525951 The phosphorylation of ERK gradually increased for 2 h after the addition of soluble FN , which suggests that activation of is *essential* for the initial induction of FN-induced PPF in [UT-7/TPO] . Positive_regulation TPR NES 9371762 466108 A functional is *required* for active export , presumably by interacting directly or indirectly with the [nuclear pore complex] . Positive_regulation TPX2 NEDD9 8143861 252373 However , only *mediated* I kappa B activity , and not that of [p100] , was inhibited by Tax . Positive_regulation TPX2 S100B 15312903 1285298 potently *activates* [p65/c-Rel] transcriptional complexes in hippocampal neurons : Clinical implications for the role of S100B in excitotoxic brain injury . Positive_regulation TPX2 S100B 15312903 1285301 Our data suggest that secreted during the glial response to brain injury potently *activates* [p65/c-Rel] in a RAGE dependent manner and may exert neuroprotective and neuroregenerative effects in psychiatric disorders . Positive_regulation TPX2 TNF 12709443 1100444 Moreover , we show that RelB , p50 , and [p100] can associate in the same complex and that but not LTbeta signaling *increases* the association of p100 with RelB/p50 dimers in the nucleus , leading to the specific inhibition of RelB DNA binding . Positive_regulation TPX2 TNF 17675290 1794077 By electrophoretic mobility shift assay analyses , and lipopolysaccharide *induce* strong p65/p50 and [p65/c-Rel] heterodimer binding to both NF-kappaB and TF-kappaB probes . Positive_regulation TPX2 TNF 19770515 2147452 TRAF3 siRNA prevented *induced* NF-kappaB [p100] accumulation and inhibition of osteoclastogenesis . Positive_regulation TPX2 TNF 19770519 2147461 *induced* a sustained accumulation of [p100] in osteoclast precursors , and TNF-alpha induced osteoclast formation was markedly increased in Nfkb2-/- mice . Positive_regulation TPX2 TNF 20923761 2347476 however , either alone or together with LIGHT *up-regulated* [p100] and RelB expression and induced the nuclear localization of p100-RelB complexes . Positive_regulation TPX2 TNF 9529131 496489 The results demonstrate that LPS , IL-1beta , and *induce* [p100] expression at mRNA and protein level while IFN-gamma , IL-3 and IL-4/IL-10 have no effect . Positive_regulation TRA TNFSF10 11784850 901103 We demonstrate that DR5 ligation by either or [TRA-8] *induces* two functional outcomes , apoptosis and expression of the chemokine interleukin-8 (IL-8) ; Positive_regulation TRADD EPHB2 8876175 390322 Serum response factor dependent [ternary complex] formation by Sap1a is *stimulated* by phosphorylation but not by SAPK/JNKs . Positive_regulation TRADD FOXO1 12446787 1017941 Involvement of *dependent* [TRADD] expression in chemotherapeutic drug induced apoptosis . Positive_regulation TRADD ITGB2 9867833 583005 This interaction may *promote* ( Mac1p ) 2.DNA [ternary complex] formation at Mac1p-responsive upstream activating sequences . Positive_regulation TRADD TNF 10599977 573794 These results suggest that can *cause* apoptosis in pancreatic beta cells through TNFR1 linked apoptotic factors , [TRADD] , FADD , and FLICE , and TNF induced ceramide production may be involved in the pathways . Positive_regulation TRADD TNF 10792026 691022 In combination with TNF-alpha , however , ceramide potentiated , whereas NO inhibited , *induced* [TRADD] recruitment and caspase 8 activity . Positive_regulation TRADD TNF 10848577 701019 Examination of Stat1-deficient cells showed an apparent increase in *induced* [TRADD-RIP] and TRADD-TRAF2 complex formation , while interaction between TRADD and FADD was unaffected . Positive_regulation TRADD TNF 17588511 1764388 In a recent issue of Molecular Cell , Kim et al. ( 2007 ) reported on a novel receptor 1 necrotic signaling complex *inducing* [TRADD-] and RIP1 dependent recruitment and activation of the ROS generating Nox1 NADPH oxidase complex . Positive_regulation TRADD TNF 18713013 1974654 Pursuing different ` TRADDes ' : [TRADD] signaling *induced* by 1 and the Epstein-Barr virus oncoprotein LMP1 . Positive_regulation TRADD TNF 18713013 1974655 Upon *stimulation* with the pro-inflammatory cytokine , [TRADD] is recruited to the activated TNFR1 by direct interaction between the death domains of both molecules . Positive_regulation TRADD TNF 19541932 2099104 Both ubiquitination and degradation of TRADD were increased in UUO kidneys , degradation of [TRADD] was *stimulated* by in HK-2 cells , and TRADD degradation was suppressed by proteasome inhibitor . Positive_regulation TRADD TNF 19541932 2099105 Inhibition of by soluble TNFR2 , etanercept , reduced significantly , although transiently , tubular and interstitial cell proliferation , fibronectin expression , and apoptosis in UUO kidneys , and also *suppressed* [TRADD] degradation . Positive_regulation TRADD TNF 8943045 399482 The recruitment of TRAF2 and c-IAP1 to TNF-R1 is dependent , is *mediated* by [TRADD] , and is independent of TNF-R2 . Positive_regulation TRAF1 EPHB2 14981539 1220344 In addition , the inhibitors , PD98059 and UO126 , *suppressed* PMA stimulated [TRAF1] promoter activity indicating a role for ERK in TRAF1 induction . Positive_regulation TRAF1 MAP2K6 14981539 1220350 In addition , the inhibitors , PD98059 and UO126 , *suppressed* PMA stimulated [TRAF1] promoter activity indicating a role for ERK in TRAF1 induction . Positive_regulation TRAF1 TNF 10544244 564076 Here we demonstrate that expression of [TRAF1] is *induced* by and the protein kinase C ( PKC ) activator PMA , but not by interleukin-1 (IL-1) . Positive_regulation TRAF1 TNF 10544244 564079 *induced* upregulation of [TRAF1] could be prevented by pretreatment of the cells with the proteasome inhibitor MG-132 , whereas the PKC inhibitor Ro31-8220 was without effect . Positive_regulation TRAF1 TNF 10657935 664300 We demonstrate for the first time dose dependent *induction* of [TRAF1] protein and messenger RNA ( mRNA ) in human H441 and A549 pulmonary adenocarcinoma cell lines , as well as in lung cells of C57BL/6J mice after intratracheal administration of TNF-alpha . Positive_regulation TRAF1 TNF 10657935 664301 In contrast to the epithelial cells , [TRAF1] was not *induced* by in U937 cells , a human monocytic cell line , suggesting cell type-specific regulation . Positive_regulation TRAF1 TNF 11028545 739577 These data demonstrate that inhibition of PMN apoptosis and [TRAF-1] *induction* by LPS and is NF-kappaB dependent . Positive_regulation TRAF1 TNF 11978013 934521 Our results , therefore , suggest that one of the mechanisms by which cells acquire resistance to TNF-alpha induced apoptosis is a *induction* of [TRAF-1] . Positive_regulation TRAF1 TNF 15851579 1399553 Overexpression of mutant IkappaB blocked *induced* [TRAF-1] , TRAF-2 , c-IAP1 , c-IAP2 , c-FLIP , and A1 gene expression and downregulated TRAF-1 protein levels . Positive_regulation TRAF1 TNF 16594899 1582766 In contrast , *stimulated* the expression of [TRAF1] and TRAF2 , recruiting both molecules onto the cell membrane poststimulation . Positive_regulation TRAF1 TNF 19383900 2066106 Furthermore , SW480 cells stably transformed with wild-type adenomatous polyposis coli showed decreased beta-catenin protein and increased *induced* p65 NF-kappaB binding as well as iNOS and [Traf1] expression . Positive_regulation TRAF1 TNF 23543740 2788901 Thus , these integrated computational-experimental studies of *induced* [TRAF1] expression identified TRAF1· Positive_regulation TRAF1 TNF 9317150 456285 These data suggest that *activates* parallel [TRAF-NF-kappa] B and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways to initiate E-selectin transcription . Positive_regulation TRAF2 EPHB2 8876175 390324 Serum response factor dependent [ternary complex] formation by Sap1a is *stimulated* by phosphorylation but not by SAPK/JNKs . Positive_regulation TRAF2 FAS 9221764 442628 Studies with human B cells show that the binding of CD154 ( gp39 , CD40L ) to CD40 recruits [TNF receptor- associated factor 2] ( TRAF2 ) and TRAF3 to the receptor complex , induces the downregulation of the nonreceptor associated TRAFs in the cell and *induces* an increased expression of on the cell surface . Positive_regulation TRAF2 ITGB2 9867833 583006 This interaction may *promote* ( Mac1p ) 2.DNA [ternary complex] formation at Mac1p-responsive upstream activating sequences . Positive_regulation TRAF2 SPHK1 11777919 916479 In addition , by using a kinase inactive dominant negative SphK and a mutant SphK that lacks TRAF2 binding motif we show that the interaction of [TRAF2] with SphK and subsequent *activation* of are critical for prevention of apoptosis during TNF stimulation . Positive_regulation TRAF2 TNF 10848577 701020 Examination of Stat1-deficient cells showed an apparent increase in *induced* TRADD-RIP and [TRADD-TRAF2] complex formation , while interaction between TRADD and FADD was unaffected . Positive_regulation TRAF2 TNF 11907583 923601 Moreover , E3-defective c-IAP1 prevented *induced* [TRAF2] degradation and inhibited apoptosis . Positive_regulation TRAF2 TNF 12748169 1113010 Also , *induced* association of FAK with RIP and subsequent association of RIP with [TRAF2] were not observed , resulting in a failure of RIP to recruit the IKK complex in FAK-/- cells . Positive_regulation TRAF2 TNF 14720501 1197830 Ebselen inhibited *induced* [TNF receptor associated factor 2 (TRAF2)-ASK1] complex formation and phosphorylation of stress activated protein kinase ERK kinase 1 ( SEK1 ) , which is an upstream signaling molecule of JNK . Positive_regulation TRAF2 TNF 16594899 1582767 In contrast , *stimulated* the expression of TRAF1 and [TRAF2] , recruiting both molecules onto the cell membrane poststimulation . Positive_regulation TRAF2 TNF 17188031 1662739 These results provide direct evidence for *induced* [TRAF2] phosphorylation and demonstrate that phosphorylation is regulated at multiple levels in the NF-kappaB pathway . Positive_regulation TRAF2 TNF 19287455 2055883 It has been shown that stimulation *leads* to degradation of [TNF receptor associated factor-2 (TRAF2)] and inhibition of TNFR1 induced activation of NFkappaB and JNK . Positive_regulation TRAF2 TNF 9317150 456286 These data suggest that *activates* parallel [TRAF-NF-kappa] B and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways to initiate E-selectin transcription . Positive_regulation TRAF3 FAS 9221764 442629 Studies with human B cells show that the binding of CD154 ( gp39 , CD40L ) to CD40 recruits TNF receptor- associated factor 2 ( TRAF2 ) and [TRAF3] to the receptor complex , induces the downregulation of the nonreceptor associated TRAFs in the cell and *induces* an increased expression of on the cell surface . Positive_regulation TRAF3 TNF 19770515 2147450 , but not RANKL , *increased* OCP expression of [TNF receptor associated factor 3 (TRAF3)] , an adapter protein that regulates NF-kappaB p100 levels in B cells . Positive_regulation TRAF3 TNF 8892903 392257 Nevertheless , the simian EBV LMP1s retain most functions in common with EBV LMP1 , including the ability to induce NF-(kappa)B activity in human cells , to bind the tumor necrosis factor associated factor 3 ( [TRAF3] ) in vitro , and to *induce* expression of genes , such as ICAM1 , in human B lymphocytes . Positive_regulation TRAF3 TNF 9317150 456287 These data suggest that *activates* parallel [TRAF-NF-kappa] B and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways to initiate E-selectin transcription . Positive_regulation TRAF4 TNF 9317150 456288 These data suggest that *activates* parallel [TRAF-NF-kappa] B and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways to initiate E-selectin transcription . Positive_regulation TRAF5 TNF 9317150 456289 These data suggest that *activates* parallel [TRAF-NF-kappa] B and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways to initiate E-selectin transcription . Positive_regulation TRAF6 EPHB2 23536866 2762729 Furthermore , our mechanistic studies indicated that NOR obviously suppressed the ubiquitination of TRAF6 , the accumulation of [TRAF6-TAK1] complexes and the *activation* of and p38 MAPK , and reduced the nuclear translocation of NF-?B-p65 and DNA binding activity of NF-?B . Positive_regulation TRAF6 ID1 20697353 2335474 *enhances* RING1b E3 [ubiquitin ligase] activity through the Mel-18/Bmi-1 polycomb group complex . Positive_regulation TRAF6 TLR7 16239509 1470992 We also determined that MyD88 , IRAK , [TRAF6] , and Toll interacting protein (Tollip) , but not TIRAP , were involved in the *mediated* response to P. aeruginosa in HAECs . Positive_regulation TRAF6 TLR7 19913487 2166473 Both proteins interact with IRAK2 and [TRAF6] and suppress *dependent* NF-kappaB activation . Positive_regulation TRAF6 TLR7 23831471 2824946 Furthermore , Atg5 deficiency increased formation of the [MyD88-TRAF6] signaling complex *induced* by stimulation , and it enhanced activation of NF-?B signaling but not MAPKs and Akt . Positive_regulation TRAF6 TNF 10920205 722517 IL-1 , but not , *induces* [TRAF6-T6BP] complex formation in a ligand dependent manner . Positive_regulation TRAF6 TNF 15898987 1408682 These findings indicate that the production of and IL-13 by LPS *required* [TLR4/MyD88/TRAF6] signalling as a common pathway of mast cell mediated inflammation . Positive_regulation TRAF6 TNF 19131965 2042492 RNF11 negatively regulated RIP1 and [TRAF6] ubiquitination upon *stimulation* with and LPS , respectively . Positive_regulation TRAF6 TNF 9317150 456290 These data suggest that *activates* parallel [TRAF-NF-kappa] B and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways to initiate E-selectin transcription . Positive_regulation TRAF7 TNF 9317150 456291 These data suggest that *activates* parallel [TRAF-NF-kappa] B and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways to initiate E-selectin transcription . Positive_regulation TRAM1 TNF 19638630 2149979 Silencing of myeloid differentiation protein ( MyD88 ) and TRIF related adaptor molecule (TRAM) , using small interfering RNA abolished IL-4 induction induced by LPS whereas silencing of TRAM has no effect on TNFalpha induction , thereby indicating that LPS induced is MyD88 dependent but IL-4 is *required* both MyD88 and [TRAM] . Positive_regulation TRAM2 TNF 19638630 2149978 Silencing of myeloid differentiation protein ( MyD88 ) and TRIF related adaptor molecule (TRAM) , using small interfering RNA abolished IL-4 induction induced by LPS whereas silencing of TRAM has no effect on TNFalpha induction , thereby indicating that LPS induced is MyD88 dependent but IL-4 is *required* both MyD88 and [TRAM] . Positive_regulation TREM1 TLR7 12646648 1070235 Expression of [TREM-1] was up-regulated in *response* to activation , an effect further enhanced by GM-CSF and TNF-alpha but inhibited by IL-10 . Positive_regulation TREM1 TLR7 18287072 1872576 Thus , PDC-TREM is responsible for IFN-alpha production , whereas signals are *essential* for [PDC-TREM] expression . Positive_regulation TREM1 TLR7 19904768 2189089 MYD88 dependent and -independent *activation* of [TREM-1] via specific ligands . Positive_regulation TREM1 TLR7 19904768 2189110 Although TLR ligands such as LPS and lipoteichoic acid have been shown to upregulate TREM-1 expression in macrophage and neutrophils , the *role* of specific in inducing the expression of [TREM-1] remains unclear . Positive_regulation TREM1 TLR7 19904768 2189130 In this study , we investigated whether the presence of is *necessary* for the expression of [TREM-1] . Positive_regulation TREM1 TLR7 19904768 2189143 These data indicate that the expression of [TREM-1] in *response* to ligands occurs secondary to downstream signaling events and that the presence of TLR is necessary for the expression of TREM-1 in response to their specific ligands . Positive_regulation TREM1 TNF 15611278 1357384 Intriguingly , in contrast to monocytes , intestinal macrophages fail to up-regulate [TREM-1] in *response* to . Positive_regulation TREM2 TLR7 18287072 1872586 Thus , PDC-TREM is responsible for IFN-alpha production , whereas signals are *essential* for [PDC-TREM] expression . Positive_regulation TREX1 TLR7 24218451 2879464 [Trex1] is highly induced in macrophages in *response* to proinflammatory stimuli , including and TLR9 ligands . Positive_regulation TRH TNF 19996183 2199742 In the hypothalamus , produces reductions in neuropeptide Y , agouti gene related peptide , proopiomelanocortin , and melanin concentrating hormone , and *increases* CRH and [TRH] . Positive_regulation TRIB3 FOXO1 24212932 2864964 Conversely , [Trib3] induction *requires* transcription factors , which show enhanced occupancy of the Trib3 promoter region following NGF withdrawal . Positive_regulation TRIB3 FOXO1 24212932 2864968 Collectively , these findings support a mechanism in which NGF deprivation , Akt dephosphorylation/inactivation , dephosphorylation/activation and [Trib3] *induction* are linked in a self amplifying feed-forward loop that culminates in neuron death . Positive_regulation TRIM21 TNF 7492240 335537 *mediates* 52 kDa [Ro(SS-A)] and La ( SS-B ) autoantigen surface expression on human keratinocytes , and may be an important factor both in antibody induction and in the initiation of immunopathogenic processes which occur after antibody binding in autoimmune dermatitis . Positive_regulation TRIM22 TNF 21345949 2415462 Moreover , overexpression of [TRIM22] in 293T cells significantly impaired basal and phorbol myristate acetate-ionomycin *induced* HIV-1 LTR-driven gene expression , whereas inhibition of alpha induced viral transcription was a consequence of lower basal expression . Positive_regulation TRIM26 FOXA1 10455192 638636 Transient transfection studies illustrate that can *activate* [AFP] expression in a non-liver cellular environment , confirming a pivotal role for HNF3alpha in establishing hepatic-specific gene expression . Positive_regulation TRIM26 FOXA1 20348100 2260675 functions as a pioneer transcription factor at transposable elements to *activate* [Afp] during differentiation of embryonic stem cells . Positive_regulation TRIM28 ZFP57 22110054 2509525 These results , together with the analysis of embryos bearing a conditional inactivation of Trim28 in embryonic derived tissues , revealed that [TRIM28] is differentially *required* by and other factors during the early stages of mouse embryogenesis . Positive_regulation TRIM33 EPHB2 12824291 1113618 These results indicate that *dependent* [R-Smad] linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells . Positive_regulation TRIM38 TLR7 22323536 2565462 [TRIM38] was *induced* by stimulation in an NF-?B dependent manner in macrophages . Positive_regulation TRIM54 FOXO1 19553561 2128954 activation *resulted* in a significant increase in muscle atrophy F-box (MAFbx)/atrogin-1 , [muscle-specific RING finger protein] 1 ( MuRF-1 ) , and Bcl-2 interacting mediator of cell death ( Bim ) gene expression , with no significant increase in Bcl-2/adenovirus E1B 19-kDa interacting protein 3 ( BNip3 ) gene expression . Positive_regulation TRIM60 TNF 21205214 2391766 Deletion and mutagenesis of the 2.5-kb sequence in luciferase constructs further demonstrated that an intronic and palindromic kappa B ( ?B ) sequence was an important cis element targeted by the nuclear factor-?B ( NF-?B ) subunits p65/RELA and p50/NF?B1 , and also through modulation by tumor necrosis factor a. Transcriptional *up-regulation* of [Rnf33] by NF-?B and was directly demonstrated in TM3 and TM4 cells by real-time PCR quantification of the Rnf33 mRNA levels . Positive_regulation TRIM63 FBXO32 18616983 1947354 Taken together , these findings indicated that leucine , isoleucine and arginine decreased mRNA levels via mTOR and that different pathways were *involved* in the effect of those amino acids on [MuRF1] mRNA levels . Positive_regulation TRIM63 FBXO32 23866982 2839184 Suppression of *resulted* in increased expression of [MuRF1] and vice versa , suggesting that the ubiquitin ligases are regulated by compensatory mechanisms . Positive_regulation TRIM63 FOXO1 15125842 1244682 a mutant form of , which prevents Akt phosphorylation , thereby *prevents* Akt mediated inhibition of [MuRF1] and MAFbx upregulation . Positive_regulation TRIM63 FOXO1 19553561 2128957 Although the ability of to *induce* [MuRF-1] gene expression appeared to be independent of DNA binding , expression of MAFbx/atrogin-1 and Bim was significantly blunted in cells expressing DNA-binding-deficient FoxO1 . Positive_regulation TRIM63 FOXO1 20079455 2218696 Results suggest that sepsis increases FOXO1 expression and activity in skeletal muscle by a glucocorticoid dependent mechanism and that glucocorticoid dependent upregulation of atrogin-1 and [MuRF1] in skeletal muscle is *regulated* by . Positive_regulation TRIM63 IL1B 19625606 2131254 We conclude that IL-1alpha and act via an oxidant- and AKT/Foxo independent mechanism to activate p38 MAPK , *stimulate* NF-kappaB signaling , increase expression of atrogin1/MAFbx and [MuRF1] , and reduce myofibrillar protein in differentiated myotubes . Positive_regulation TRIM8 TNF 23152791 2699826 *induces* translocation of [TRIM8] from nucleus to cytoplasm , which positively regulates NF-?B . Positive_regulation TRPC1 GPR115 18323855 1897671 [TRPP2/TRPC1] is activated in *response* to activation and shows a pattern of single-channel conductance , amiloride sensitivity and ion permeability distinct from that of TRPP2 or TRPC1 alone . Positive_regulation TRPC1 GPR132 18323855 1897660 [TRPP2/TRPC1] is activated in *response* to activation and shows a pattern of single-channel conductance , amiloride sensitivity and ion permeability distinct from that of TRPP2 or TRPC1 alone . Positive_regulation TRPC1 GPR87 18323855 1897740 [TRPP2/TRPC1] is activated in *response* to activation and shows a pattern of single-channel conductance , amiloride sensitivity and ion permeability distinct from that of TRPP2 or TRPC1 alone . Positive_regulation TRPC1 TNF 12855710 1141615 *induces* nuclear factor-kappaB dependent [TRPC1] expression in endothelial cells . Positive_regulation TRPC1 TNF 12855710 1141619 Treatment with NEMO binding domain peptide , which prevents NF-kappaB activation by selectively inhibiting IKKgamma interaction with IKK complex , also blocked the *induced* [TRPC1] expression . Positive_regulation TRPC1 TNF 12855710 1141621 Thus , *induces* [TRPC1] expression through an NF-kappaB dependent pathway in endothelial cells , which can trigger augmented Ca2+ entry following Ca2+ store depletion . Positive_regulation TRPC1 TNF 17085428 1643708 Further , evidence suggests that the inflammatory cytokine can *induce* the expression of [TRPC1] in human vascular endothelial cells signaling via the nuclear factor-kappaB pathway . Positive_regulation TRPC3 IL1B 15001625 1217074 but exclusively *up-regulated* [TrpC3] protein expression ( P < or = 0.05 ) . Positive_regulation TRPC3 TNF 20360250 2255229 also *induced* [TRPC3] expression and TRPC3 mediated constitutive cation influx and currents . Positive_regulation TRPC3 TNF 21290324 2388242 Supportively , , an important asthma mediator , *increases* [TRPC3] expression , and TRPC3 gene silencing inhibits TNFa mediated augmentation of acetylcholine evoked increase in [ Ca ( 2+ ) ] ( i ) in passaged airway SMCs . Positive_regulation TRPC6 EPHB2 19546355 2121454 [TRPC6] up-regulation in Ang II-induced podocyte apoptosis might *result* from activation and NF-kappaB translocation . Positive_regulation TRPC6 EPHB2 23875811 2854478 [TRPC6] channel mediated neurite outgrowth in PC12 cells and hippocampal neurons *involves* activation of , PI3K , and CAMKIV signaling . Positive_regulation TRPC6 MAP2K6 23875811 2854486 [TRPC6] channel mediated neurite outgrowth in PC12 cells and hippocampal neurons *involves* activation of , PI3K , and CAMKIV signaling . Positive_regulation TRPM6 TLR7 16547253 1537703 [HSH2] expression is increased in *response* to anti-CD40 mAb , the ligands LPS and CpG DNA , and B lymphocyte stimulator (BLyS) , a key regulator of peripheral B cell survival and homeostasis . Positive_regulation TRPM7 ALOX5 22135214 2568496 The MIP and [TRPM7] currents were *inhibited* by <5-lipoxygenase> inhibitors . Positive_regulation TRPM7 TNF 24316671 2894851 Furthermore , we identified that [TRPM7] ( transient receptor potential melastatin related 7 ) is a MLKL downstream target for the mediation of Ca ( 2+ ) influx and *induced* necroptosis . Positive_regulation TRPV1 EPHB2 12595244 1061205 Constitutive simultaneous stimulation of both and phosphatidylinositol 3-kinase is not *sufficient* for [VR1] upregulation . Positive_regulation TRPV1 EPHB2 17851089 1817832 Furthermore , we found that activation of but not of p38 kinase or cyclooxygenases is critically *involved* in the TNFalpha induced increase of [TRPV1] receptor expression . Positive_regulation TRPV1 HRH1 20006972 2199896 The present results suggest that histamine sensitizes acid induced responses through [TRPV1] *activation* via coupled with PLC/PKC pathways , the action of which may be involved in the generation of inflammatory pain . Positive_regulation TRPV1 MAP2K6 12595244 1061182 Upregulation of [VR1] by nerve growth factor and glial cell line derived neurotrophic factor is partially *blocked* by a inhibitor . Positive_regulation TRPV1 MAP2K6 18034335 1924425 In summary , the activation of [TRPV1] by capsaicin modulates the SP release from DRG neurons via two different mechanisms , one requiring extracellular Ca2+ , the activation of PI3K and the IP3 dependent intracellular Ca2+ release , and the other which is independent of extracellular Ca2+ but *involves* the activation of . Positive_regulation TRPV1 TNF 17851089 1817831 Furthermore , we found that activation of ERK but not of p38 kinase or cyclooxygenases is critically involved in the *induced* increase of [TRPV1] receptor expression . Positive_regulation TRPV1 TNF 18582539 1953145 A brief ( 5 min ) application of TNFalpha significantly sensitized capsaicin evoked accumulation of intracellular calcium ( [ Ca2+ ] i ) ( 226.4+/-37.7 nM vs. 167.5+/-31.3 nM ) and increased capsaicin evoked nocifensive behavior ( 78.3+/-9.7 vs. 30.9+/-3.6 s ) as compared with vehicle pretreatment ( P < 0.01 for both ) . Sustained ( 30 min to 4 h ) exposure of cultured neurons to TNFalpha evoked a twofold increase in mRNA transcript ( P < 0.05 ) and protein levels ( P < 0.01 ) of transient potential receptor vanilloid type 1 ( TRPV1 ) . This long-term *up-regulation* of [TRPV1] expression by correlated with enhancement in capsaicin induced calcitonin gene related peptide release ( P < 0.05 ) . Demonstration of colocalization of TNFalpha receptor subtypes I and II with TRPV1 in almost all ( > 90 % ) Positive_regulation TRPV5 F2R 23024298 2694521 In summary , activation by plasmin *induces* PKC mediated phosphorylation of [TRPV5] , thereby altering calmodulin-TRPV5 binding , resulting in decreased channel activity . Positive_regulation TSC1 GPR115 17329974 1706897 [Akt/TSC/mTOR] *activation* by the KSHV : emerging insights into the molecular oncogenesis and treatment of Kaposi 's sarcoma . Positive_regulation TSC1 GPR132 17329974 1706886 [Akt/TSC/mTOR] *activation* by the KSHV : emerging insights into the molecular oncogenesis and treatment of Kaposi 's sarcoma . Positive_regulation TSC1 GPR87 17329974 1706966 [Akt/TSC/mTOR] *activation* by the KSHV : emerging insights into the molecular oncogenesis and treatment of Kaposi 's sarcoma . Positive_regulation TSC2 DAPK1 18974095 2015056 Transfection of *promotes* phosphorylation of [TSC2] in vivo , whereas short interfering RNA mediated attenuation of DAPK reduces growth factor stimulated phosphorylation of TSC2 . Positive_regulation TSHB NT5E 6094284 42943 [Thyrotropin] *increases* <5'-nucleotidase> activity in primary cultures of porcine thyroid cells . Positive_regulation TSLP TLR7 21690322 2455599 DCs are important primary targets of TSLP , and we unexpectedly demonstrated that DCs also produce [TSLP] in *response* to stimulation and that this is augmented by IL-4 . Positive_regulation TSLP TLR7 23413283 2860783 In cultured human and mouse skin fibroblasts , [TSLP] expression was *inducible* by activation of , particularly TLR3 . Positive_regulation TSLP TLR7 24377934 2895308 Here , we describe on *mediated* induction of [TSLP] expression in primary cultured human KCs , placing emphasis on experimental methods used in our studies . Positive_regulation TSLP TLR7 24377934 2895318 Atopic cytokine milieu upregulated the mediated *induction* of [TSLP] . Positive_regulation TSLP TNF 17416344 1728595 In addition , *up-regulated* [TSLP] expression in RA- and OA-derived synovial fibroblasts , which was inhibited by IFN-gamma . Positive_regulation TSLP TNF 17513456 1772842 Taken together , our data provide the first evidence of IL-1beta- and *induced* [TSLP] expression in HASMC via ( p38 , p42/p44 ) MAPK signaling pathways . Positive_regulation TSLP TNF 20228393 2237582 IL-4 and or pregnancy associated hormones *result* in a significant increase in [TSLP] mRNA expression and protein release from EVT , and TSLP promotes primary EVT proliferation and invasion in vitro . Positive_regulation TSLP TNF 21109746 2413958 The flagellin induced release of [TSLP] was *enhanced* by the cytokines or TGF-a . Positive_regulation TSLP TNF 21148792 2396225 Essential role of NF-?B and AP-1 transcription factors in *induced* [TSLP] expression in human airway smooth muscle cells . Positive_regulation TSLP TNF 21148792 2396229 In this study , we found that upregulates the TSLP mRNA and *induces* high levels of [TSLP] protein release in primary human ASM cells . Positive_regulation TSLP TNF 21148792 2396231 Interestingly , *induced* the [TSLP] promoter activity ( P < 0.05 ; n = 4 ) in HASM that was mediated by upstream NF-?B and activator protein-1 (AP-1) binding sites . Positive_regulation TSLP TNF 21148792 2396232 Furthermore , the peptide inhibitors of I?B kinase or NF-?B inhibited the *induced* [TSLP] protein release ( P < 0.05 ; n = 3 ) in HASM . Positive_regulation TSLP TNF 21148792 2396233 Collectively , our data suggest a novel important biological role for NF-?B pathway in *induced* [TSLP] expression in HASM and recommend this as a prime target for anti-inflammatory drugs . Positive_regulation TSLP TNF 24518171 2938298 Our results show that IL-4 , IL-13 , IL-31 , and induce spongiosis , *augment* [TSLP] secretion by keratinocytes , and alter early and terminal differentiation-protein expression in LEMs . Positive_regulation TSPAN1 MDK 18851943 1988630 *promotes* [tetraspanin-integrin] interaction and induces FAK-Stat1alpha pathway contributing to migration/invasiveness of human head and neck squamous cell carcinoma cells . Positive_regulation TSPAN1 MYLIP 23938385 2827026 TSPAN1 was proved to induce migration , and so *up-regulation* of [TSPAN1] by may explain why over expressing miR-200a promotes NSCLC cells migration . Positive_regulation TSPAN1 THPO 15512913 1328298 and FN *increased* expression of [tetraspanin] molecules , CD63 and CD151 , as well as their co-expression with the beta ( 1 ) -integrins on both the CD34 ( + ) and CD34 ( - ) cells ( e.g. and increase from 0 % to 80 % co-expression of CD49d and CD151 on CD34 ( + ) ) . Positive_regulation TSPAN31 IL1B 9343751 459042 [SaS] also *induced* the release of TNF-alpha and by human monocytes . Positive_regulation TSPAN31 TNF 9343751 459041 [SaS] also *induced* the release of and IL-1 beta by human monocytes . Positive_regulation TSPAN7 IL1B 17620096 1769839 In cultured keratinocytes , and Th1 cytokines significantly *induced* [hS100A15-L] compared with hS100A15-S . Positive_regulation TSPO TNF 11077046 749231 As Bcl-2 has been shown to be an endogenous inhibitor of the PT pore , we hypothesize that the *induced* up-regulation of [PBR] expression may compensate for the decrease in Bcl-2 levels to prevent the opening of the PT pore . Positive_regulation TSPO TNF 22616995 2603976 [PBR] expression is *increased* by in endothelial cells . Positive_regulation TST TCN1 21512823 2458436 of ketamine with a Ce of 30 and 60 ng/ml *increased* [TST] but not HPT . Positive_regulation TTN CAPN8 14676206 1211122 Anthracyclines induce *dependent* [titin] proteolysis and necrosis in cardiomyocytes . Positive_regulation TTN CAPN8 7787305 313034 The present data suggest that the degradation of [connectin] in muscle might be *caused* by in the early stage of aging , and then with time , this action is replaced by m-calpain or cathepsin D . Positive_regulation TTN MMP28 21041693 2349146 Both purified [titin] and titin in skinned cardiomyocytes were proteolyzed when incubated with MMP-2 in a concentration dependent manner , and this was *prevented* by inhibitors . Positive_regulation TTN MMP28 21041693 2349168 Inhibition of activity with ONO-4817 *prevented* ischemia/reperfusion induced [titin] degradation and improved the recovery of myocardial contractile function . Positive_regulation TTN MMP7 21041693 2349161 Both purified titin and [titin] in skinned cardiomyocytes were proteolyzed when incubated with MMP-2 in a concentration dependent manner , and this was *prevented* by inhibitors . Positive_regulation TTN MMP7 21041693 2349183 Inhibition of activity with ONO-4817 *prevented* ischemia/reperfusion induced [titin] degradation and improved the recovery of myocardial contractile function . Positive_regulation TTR F2R 17102904 1709092 In addition , direct activation of PAR-2 by hexapeptide SLIGKV increased P(alb) comparable to MCC , whereas activation by TFLLRN *had* no effect on [P(alb)] . Positive_regulation TTR IGFBP1 12359954 994811 Serum [pre-albumin] and cholinesterase *increased* with , whereas serum creatinine decreased when compared to controls ( p < 0.05 ) . Positive_regulation TTR TF 12644233 1069629 *dependent* expression of [TbpA] by Histophilus ovis involves a poly G tract within tbpA . Positive_regulation TTR TF 12644233 1069631 A poly G tract in tbpA of Histophilus ovis strain 3384Y was suspected of being responsible for the *dependent* expression of [TbpA] . Positive_regulation TTR TNF 16303918 1526140 In isolated glomeruli , *increased* [P(alb)] and tempol abrogated this effect , both in a dose dependent manner . Positive_regulation TUB ERC2 11950928 930364 The low nucleation activity of the [Tub4p] complex is not *enhanced* when it is bound to , suggesting that it requires additional components or modifications to achieve robust activity . Positive_regulation TUB IGF1 10455176 638603 Here we demonstrate that in CHO-IR cells , transfected [Tub] is phosphorylated on tyrosine in *response* to insulin and and that in PC12 cells , insulin but not EGF induced tyrosine phosphorylation of endogenous Tub . Positive_regulation TUB INS 10455176 638604 Here we demonstrate that in CHO-IR cells , transfected [Tub] is phosphorylated on tyrosine in *response* to and insulin-like growth factor-1 and that in PC12 cells , insulin but not EGF induced tyrosine phosphorylation of endogenous Tub . Positive_regulation TUB INS 22966070 2716056 In hypothalamus of mice administered a high-fat diet , there is a reduction in leptin and *induced* [Tub-p-tyr] and nuclear translocation , which is reversed by reducing protein tyrosine phosphatase 1B expression . Positive_regulation TUB SOX9 11950928 930363 The low nucleation activity of the [Tub4p] complex is not *enhanced* when it is bound to , suggesting that it requires additional components or modifications to achieve robust activity . Positive_regulation TUBGCP2 IL1B 9365109 463089 Quantitative studies of mRNA expression in diploid fibroblasts revealed [GCP-2] *induction* by . Positive_regulation TUBGCP4 AXIN2 19390532 2089370 These results suggest that , but not Axin2 , is *involved* in microtubule nucleation by forming a complex with [gamma-tubulin] at the centrosome . Positive_regulation TUBGCP5 AXIN2 19390532 2089374 These results suggest that , but not Axin2 , is *involved* in microtubule nucleation by forming a complex with [gamma-tubulin] at the centrosome . Positive_regulation TUBGCP6 AXIN2 19390532 2089372 These results suggest that Axin , but not , is *involved* in microtubule nucleation by forming a complex with [gamma-tubulin] at the centrosome . Positive_regulation TUFM EPHB2 11818442 908183 [p43-Dependent] *activation* of was inhibited by PI3-K inhibitors , and the activation of p38 MAPK was not . Positive_regulation TUFM FAS 20212524 2223115 We validated experimentally that stimulation *resulted* in an interaction of [p43-FLIP] with the IKK complex followed by its activation . Positive_regulation TUFM MUC16 23663754 2810874 The expression of adhesin [EF-Tu] in *response* to and its role in Lactobacillus adhesion and competitive inhibition of enteropathogens to mucin . Positive_regulation TUFM TNF 15681823 1366516 In skin wound regions from mice , *induced* [p43] expression and secretion from macrophages recruited to the site . Positive_regulation TWIST1 MAOA 24865426 2945512 dependent activation of neuropilin-1 *promoted* [AKT/FOXO1/TWIST1] signaling , allowing FOXO1 binding at the TWIST1 promoter . Positive_regulation TWIST1 TNF 22253230 2564413 Both IKK-ß and NF-?B p65 were required for *induced* expression of [Twist1] , suggesting the involvement of canonical NF-?B signaling . Positive_regulation TXN EPHB2 20430109 2288030 Japanese encephalitis virus down-regulates [thioredoxin] and *induces* ROS mediated MAPK activation in human promonocyte cells . Positive_regulation TXN FOXO1 19254690 2051111 *Up-regulation* of [thioredoxin interacting protein (Txnip)] by p38 MAPK and contributes to the impaired thioredoxin activity and increased ROS in glucose treated endothelial cells . Positive_regulation TXN IL1B 16207716 1483381 Extracellular human [thioredoxin-1] inhibits lipopolysaccharide *induced* expression in human monocyte derived macrophages . Positive_regulation TXN TGM2 21908620 2496791 *Activation* of extracellular by [thioredoxin] . Positive_regulation TXN TNF 10329406 613179 The results showed that *induced* p38 MAP kinase activation and interleukin-6 (IL-6) production by [TRX] 14 were less than those by the parental L cells and the control transfected L cells ( Neo-1 ) . Positive_regulation TXN TNF 10555039 565800 Stimulation of synovial fibroblast-like synoviocytes with either H2O2 or *induced* an increase in the production of [TRX] . Positive_regulation TXN TNF 21636804 2454895 Thioredoxin interacting protein mediates [TRX1] translocation to the plasma membrane in *response* to : a key mechanism for vascular endothelial growth factor receptor-2 transactivation by reactive oxygen species . Positive_regulation TXNIP FOXO1 24112473 2867824 Activation of the pathway and [TXNIP] *induction* were examined by Western blotting , fluorescence microscopy , Chromatin immunoprecipitation ( ChIP ) assay , and reporter gene assay . Positive_regulation TXNIP RNASE1 22883233 2641824 Finally , small molecule IRE1a inhibitors *suppress* [TXNIP] production to block IL-1ß secretion . Positive_regulation TXNIP RNASE7 22883233 2641832 Finally , small molecule IRE1a inhibitors *suppress* [TXNIP] production to block IL-1ß secretion . Positive_regulation TXNRD1 TNF 14584040 1187130 In the present study , we found that among these isozymes only [TrxR1] was *induced* by in vascular endothelial cells . Positive_regulation TXNRD2 TNF 15178321 1255218 *caused* accumulation of oxidized [TrxR2] with a thioselenide bond . Positive_regulation TYK2 TNF 11801527 902547 Here we present evidence that *induces* the activation of the cytoplasmic Janus tyrosine kinases Jak1 and [Tyk2] in both human healthy peripheral and lymphoma B cells . Positive_regulation TYK2 TNF 9510175 491847 In this study , we show that murine *induces* the tyrosine phosphorylation and activation of the intracellular Janus tyrosine kinases Jak1 , Jak2 , and [Tyk2] in murine 3T3-L1 adipocytes . Positive_regulation TYMP IL1B 11732857 885241 *induced* expression of matrix metalloproteinases and gliostatin/platelet derived endothelial cell growth factor ( [GLS/PD-ECGF] ) in a chondrosarcoma cell line ( OUMS-27 ) . Positive_regulation TYMP TNF 12466967 1022422 The Sp1 transcription factor contributes to the *induced* expression of the angiogenic factor [thymidine phosphorylase] in human colon carcinoma cells . Positive_regulation TYMP TNF 9348223 460636 Thus , in NEE cells , [PD-ECGF/TP] expression was strongly *induced* by the combination and interferon-gamma . Positive_regulation TYR ADRB2 17008315 1647461 Apart from Galpha ( s ) QL , the stimulation of Galpha ( s ) by cholera toxin or and the activation of adenylyl cyclase by forskolin , ( Sp ) -cAMP , or dibutyryl-cAMP all *promoted* both STAT3 [Tyr705] and Ser727 phosphorylations . Positive_regulation TYR CAPN8 16335789 1491267 These results indicate that would be *involved* in the melanogenic signaling by modulating the expression of [tyrosinase] in mouse B16 melanoma cells . Positive_regulation TYR EFNB1 17310244 1699567 Phosphorylation of [Tyr392] and the recruitment of GIT1 to synapses are *regulated* by activation . Positive_regulation TYR FAS 14679192 1211246 Additionally , in CD95-yellow fluorescent protein transfected Huh7-hepatoma cells , ONOO ( - ) induced CD95 Tyr nitration and prevented *induced* [Tyr] phosphorylation and apoptosis . Positive_regulation TYR HBEGF 20739666 2345870 Western blot analysis of HER1 activation demonstrated that *mediated* phosphorylation of the HER1 [Tyr992] and Tyr1068 sites , while EGF activated the Tyr1045 site . Positive_regulation TYR HES2 15610895 1357241 We also report here formation of the depurinating 3'-OH-HES-6'-N7Gua and 3'-OH-HES-6'-N3Ade adducts by reaction of HES-3',4'-Q with DNA or by *activation* of <3'-OH-HES> by [tyrosinase] , lactoperoxidase , prostaglandin H synthase or 3-methylcholanthrene induced rat liver microsomes in the presence of DNA . Positive_regulation TYR IL1B 8176258 255787 We have now also shown that *induces* an inhibiting effect on neonatal melanocyte [tyrosinase] activity with little effect on melanocyte proliferation . Positive_regulation TYR PDZK1 22696060 2681733 The *induced* [tyrosinase] expression and melanosome transfer was regulated by ion transporters such as sodium-hydrogen exchanger ( NHE ) , cystic fibrosis transmembrane conductance regulator ( CFTR ) , and SLC26A3 , which showed a specific association with each ER subtype . Positive_regulation TYR PLAT 20724593 2323793 The mitogenic effect of *required* [Tyr] ( 4507 ) phosphorylation of the cytoplasmic tail of its receptor LDL receptor related protein 1 . Positive_regulation TYR PLAT 20724593 2323799 These findings show that *induces* [Tyr] ( 4507 ) phosphorylation of LDL receptor related protein 1 , which in turn leads to the downstream phosphorylation of Erk1/2 , p90RSK , and GSK3ß , followed by the induction of cyclin D1 in murine interstitial fibroblasts . Positive_regulation TYR TNF 20308428 2230597 We find that depletion of p110alpha but not other p110 isoforms decreases *induced* endothelial permeability , [Tyr] phosphorylation of the adherens junction protein vascular endothelial cadherin ( VE-cadherin ) , and leukocyte TEM . Positive_regulation TYR WIF1 24131586 2889339 The upregulation of on cultured normal human melanocytes significantly *induced* expressions of MITF and [tyrosinase] , which were associated with increased melanin content and tyrosinase activity . Positive_regulation TYRP1 ARSA 10889256 710422 Hairy root lines transformed with 35S-ASA2 grew in concentrations of up to 100 microM 5MT , whereas the controls were completely inhibited by 15 microM 5MT. Expression of the feedback-insensitive *resulted* in a 1.3- to 5.5-fold increase in free [Trp] . Positive_regulation TYRP1 MAP2K6 12606410 1064523 The nitric oxide mediated increase of [P-Thr-Glu-Tyr-P] *involved* protein Tyr kinase , or MEK-like kinase , and protein kinase C but not protein kinase A . Positive_regulation TYRP1 TGM2 25009701 2948421 Meanwhile , gene silencing of *suppressed* dendrite extension and the expressions of [TRP-1] and TRP-2 in a-MSH treated SK-MEL-2 cells . Positive_regulation UBC TNF 19854138 2155764 We further show that IKK activation by *requires* [Ubc5] , which functions with the E3 cIAP1 to catalyze polyubiquitination of RIP1 not restricted to K63 of ubiquitin . Positive_regulation UBD TNF 20433827 2282486 and IFNg treatment of HCC cell line Hepa 1-6 , *induced* the expression of [UbD] and the expression of genes coding for the immunoproteasome ( LMP2 , LMP7 , and MECL-1 subunits ) . Positive_regulation UBD TNF 20433827 2282489 and IFNg *induced* the activity of the [UbD] promoter , using a luciferase assay . Positive_regulation UBE2G2 AGR2 23942235 2840870 Structural analysis of the RING : Ube2g2 : G2BR complex reveals that *induced* conformational effect at the RING : Ube2g2 interface is necessary for enhanced binding of RING to [Ube2g2] or Ube2g2 conjugated to Ub . Positive_regulation UBE2H TNF 12773487 1095115 *stimulates* [UbcH2] expression in mouse limb muscles in vivo and in cultured myotubes . Positive_regulation UBE2V1 ID1 20697353 2335475 *enhances* RING1b E3 [ubiquitin ligase] activity through the Mel-18/Bmi-1 polycomb group complex . Positive_regulation UCA1 ETS2 24069250 2847109 Further analysis of this site by gel shifting , chromatin immune precipitation ( ChIP ) , and co-transfection experiments showed that transcription factor directly bound to the UCA1 promoter region and *stimulated* [UCA1] promoter activity in bladder cancer cells . Positive_regulation UCA1 PTBP1 24457952 2907481 The present study demonstrates that can also form a functional ribonucleoprotein complex with lncRNA urothelial carcinoma associated 1 (UCA1) and *increase* the [UCA1] stability . Positive_regulation UCHL1 TNF 8766549 374985 In contrast , neither mAb 10G10 , which recognizes an epitope distinct from the one recognized by mAb 4B2 , nor mAb [UCHL-1] , a CD45RO-specific antibody , *induced* any significant increase in transcription . Positive_regulation UCN TNF 16340217 1519235 and interferon-gamma *increased* the [urocortin] mRNA levels and its release from HUVECs . Positive_regulation UCN TNF 19318426 2073567 In addition , the secretion of [Ucn] I from HL-1 cardiomyocytes was *stimulated* by LPS and . Positive_regulation UCP1 IL1B 17164436 1716986 Brown fat [UCP1] is not involved in the febrile and thermogenic *responses* to in mice . Positive_regulation UCP1 PGC 11875072 936963 As in rodents , is *involved* in the transcriptional regulation of the [UCP1] gene in humans and mediates the effects of PPARalpha and PPARgamma agonists and retinoic acid . Positive_regulation UCP1 PGC 21054343 2376356 Reducing expression also *led* to reduced mRNA expression levels of [uncoupling protein 1] , 2 ( UCP1 and UCP2 ) and superoxide dismutase 2 . Positive_regulation UCP1 PGC 22561685 2631939 Rald induced uncoupling protein-1 (Ucp1) mRNA and protein levels in white adipocytes by selectively activating the retinoic acid receptor ( RAR ) , recruiting the coactivator and *inducing* [Ucp1] promoter activity . Positive_regulation UCP1 TNF 10884431 709575 The absence of both receptors or p55 receptor alone *resulted* in a significant reduction in brown adipocyte apoptosis and an increase in beta(3)-adrenoreceptor and [uncoupling protein-1] expression in obese mice . Positive_regulation UCP1 TNF 16644673 1553114 Using reduced MitoTracker Red probe , we confirmed that *increased* mitochondrial ROS production , which was suppressed by overexpression of either [uncoupling protein-1 (UCP)-1] or manganese superoxide dismutase ( MnSOD ) . Positive_regulation UCP1 TNF 9492058 489855 However , the expression of the tissue-specific gene , [uncoupling protein 1] , is *increased* by the presence of . Positive_regulation UCP2 FOXA1 23625627 2887246 Overexpression of by full-length complementary DNA *reduced* UCP2 expression , while silencing of FoxA1 expression by small interfering RNA significantly increased [UCP2] levels . Positive_regulation UCP2 FOXA1 23625627 2887247 The overexpression of promoted the DNA binding activity and *attenuated* the transcription of [UCP2] promoter as shown by electromobility shift , chromatin immunoprecipitation assays , and luciferase reporter assay . Positive_regulation UCP2 IL1B 9514886 492957 In liver , both ( 1 microgram , i.p. ) and TNF ( 5 micrograms , i.p. ) *increased* [UCP2] mRNA levels , 4- and 3-fold respectively , whereas in muscle and fat tissue , an increase was detectable after TNF , but not IL-1 beta . Positive_regulation UCP2 TNF 10092993 601021 treatment *induced* an increase in [UCP2] mRNA expression in broadly distributed tissues including brown adipose tissue (BAT) , white adipose tissue ( WAT ) and skeletal muscle , and an elevation of ob gene mRNA expression in WAT . Positive_regulation UCP2 TNF 11782473 916665 Peroxisome proliferator activated receptor-alpha ( PPARalpha ) activators , fish oil feeding , or fibrate administration up-regulated mitochondrial uncoupling protein ( UCP2 ) mRNA expression in mouse liver by 5-9-fold , whereas also *up-regulated* [UCP2] in liver . Positive_regulation UCP2 TNF 11782473 916667 These data indicate that PPARalpha activators up-regulate [UCP2] expression in hepatocytes through unknown proteins by increased transcription , and neither ROS nor production are the major *causes* for PPARalpha activators induced UCP2 up-regulation . Positive_regulation UCP2 TNF 15172192 1253946 further *enhanced* [UCP-2] transcripts , inducing massive hepatocellular necrosis during acute rejection . Positive_regulation UCP2 TNF 9514886 492956 In liver , both IL-1 beta ( 1 microgram , i.p. ) and ( 5 micrograms , i.p. ) *increased* [UCP2] mRNA levels , 4- and 3-fold respectively , whereas in muscle and fat tissue , an increase was detectable after TNF , but not IL-1 beta . Positive_regulation UCP2 TNF 9790953 542484 Futhermore , treatment *induces* [UCP-2] mRNA accumulation in primary cultures of hepatocytes from healthy rats . Positive_regulation UCP3 FAS 21508290 2448988 Avian [UCP3] mRNA expression , associated with p38 mitogen activated protein kinase ( p38 MAPK ) activation , was *increased* by Iso and/or . Positive_regulation UFD1L EPHB2 10648884 662334 [Membrane] depolarization *induced* calcium increases activated both and p38 kinase within 5 min . Positive_regulation UFD1L TNF 12606436 1064547 [Membrane] type-1 MMP mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation UGCG EPHB2 11097862 755844 Inhibition of and p38 MAP kinases *inhibits* binding of Nrf2 and induction of [GCS] genes . Positive_regulation UGCG EPHB2 11097862 755847 These studies indicate that and p38 *contribute* to the transcriptional up-regulation of the [GCS] subunit genes following PDTC treatment . Positive_regulation UGCG HSD11B2 10727009 677758 The metabolic *activation* of [GCS] by <11beta-HSD> could possibly lead to an excess of GCS in the hepatocytes . Positive_regulation UGCG HSD11B2 14756370 1205837 That changes in integumentary <11beta-HSD-1> activity associated with the laminitic condition would *lead* to elevated local tissue levels of [GCs] , which could subsequently contribute , through paracrine and autocrine mechanisms , to the further development of laminitis ; Positive_regulation UGCG IL1B 8662965 367735 In summary , the expression of [gamma-GCS] is *regulated* by TNF-alpha or in endothelial cells mediated by NF-kappaB stimulation , and impairment of the regulation of gamma-GCS in hyperglycemic cells may be a cause of medical complications that develop in diabetes mellitus . Positive_regulation UGCG JAG1 22529295 2602554 One widely cited model posits that long lived plasma cells derive from [germinal centers (GCs)] in *response* to T cell dependent ( TD ) . Positive_regulation UGCG TNF 10496964 647241 We show that dissociated [GCs] repress *induced* interleukin-6 gene expression by an NF-kappaB dependent mechanism , without changing the expression level of inhibitor kappaB . Positive_regulation UGCG TNF 11007940 735639 also *induces* the activation of NF-kappa B and AP-1 and the subsequent increase in [gamma-GCS] heavy subunit transcription in these cells . Positive_regulation UGCG TNF 8662965 367734 In summary , the expression of [gamma-GCS] is *regulated* by or IL-1beta in endothelial cells mediated by NF-kappaB stimulation , and impairment of the regulation of gamma-GCS in hyperglycemic cells may be a cause of medical complications that develop in diabetes mellitus . Positive_regulation UGCG TNF 9374527 465135 The capacity to synthesize GSH de novo determined in cell-free extracts incubated with GSH precursors was greater ( 50-70 % ) in hepatocytes that were treated with TNF ; however , the activity of GSH synthetase remained unaltered by TNF treatment indicating that selectively *increased* the activity of [gamma-GCS] . Positive_regulation UGCG TNF 9374527 465146 Despite activation of nuclear factor-kappaB (NF-kappaB) by TNF , this transcription factor was not required for *induced* transcription of [gamma-GCS-HS] as revealed by deletion constructs of the gamma-GCS-HS promoter subcloned in a chloramphenicol acetyltransferase reporter vector and transfected into HepG2 cells . Positive_regulation UGGT2 FOXA1 20628005 2316503 Furthermore , down-regulation of in LNCaP cells substantially *reduces* [UGT2B17] mRNA levels . Positive_regulation UGGT2 FOXA1 20736324 2345813 We recently reported that *regulates* the basal expression of the [UGT2B17] gene in prostate cancer cells . Positive_regulation UGT1A3 ABCG2 23428312 2765215 In LS180 cells , rilpivirine *induced* mRNA expression of ABCB1 , CYP3A4 and [UGT1A3] , whereas ABCC1 , ABCC2 , , OATP1B1 and UGT1A9 were not induced . Positive_regulation UGT1A3 ABCG2 24332840 2905164 In LS180 cells , telaprevir strongly induced mRNA expression of ( 4.3-fold at 30 µmol/L ) and weakly *induced* ABCB11 , CYP2C19 and [UGT1A3] . Positive_regulation UGT1A6 AHR 19831498 2187367 *Induction* of [UGT1A6] by was studied in the Caco-2 human colon carcinoma cell line . Positive_regulation UGT1A6 AHR 19831498 2187368 Similar to the induction of cytochrome-1 ( CYP1 ) enzymes , the induction of human [UGT1A6] was *due* to the binding of to a common binding motif , a xenobiotic response element ( XRE ) in the promoter/enhancer region of the gene . Positive_regulation UGT1A6 AHR 21357386 2415692 *mediated* expression of uridine-glucuronyl transferase isozyme [UGT1A6] was induced by DL-PCBs only . Positive_regulation UGT1A6 AHR 21902811 2554851 These findings suggest that BNF induces [UGT1A6] in MCF-7 cells and that the increase may be *mediated* by but not pregnane X receptor (PXR)/constitutive androstane receptor (CAR) . Positive_regulation UGT1A6 ASIP 10049505 592639 The *role* of in [UGT1A6] was investigated by comparing some properties of UGT mutant proteins that have a single mutation ( D446K , D446E , D446N , D446Q , D446A , and D446T ) . Positive_regulation UGT1A6 CYP1A1 20551240 2302237 In particular , [Ugt1a6] and Cyp2b1 were *increased* by BNF , , Cyp3a1 , and Ugt2b1 by PB , and Cyp3a1 and Ugt2b1 by CLO . Positive_regulation UGT1A6 CYP3A 20551240 2302238 In particular , [Ugt1a6] and Cyp2b1 were *increased* by BNF , Cyp1a1 , , and Ugt2b1 by PB , and Cyp3a1 and Ugt2b1 by CLO . Positive_regulation UGT1A6 NR1I2 21902811 2554852 These findings suggest that BNF induces [UGT1A6] in MCF-7 cells and that the increase may be *mediated* by AhR but not androstane receptor (CAR) . Positive_regulation UGT1A6 NR1I3 21902811 2554853 These findings suggest that BNF induces [UGT1A6] in MCF-7 cells and that the increase may be *mediated* by AhR but not pregnane X receptor <(PXR)/constitutive androstane receptor (CAR)> . Positive_regulation UGT1A6 PAH 8903507 393956 Using cultured rat hepatocytes , we have demonstrated that *induction* of cytochrome P4501A1 , glutathione S-transferase Ya1 , and [UDP-glucuronosyltransferase 1*6] are apparently potentiated two- to fourfold upon inclusion of glucocorticoids in the media to activate the glucocorticoid receptor and further , that the receptor antagonist RU 38486 reverses these phenomenon . Positive_regulation UGT1A6 PAH 9762354 536860 3. Transient transfection studies , using human UGT1A6/CAT fusion constructs and colon carcinoma Caco-2 cells , revealed that *induction* of human [UGT1A6] is mediated by the Ah receptor . Positive_regulation UGT1A6 PRKCD 20196639 2237015 *Role* for in the functional activity of human [UGT1A6] : implications for drug-drug interactions between PKC inhibitors and UGT1A6 . Positive_regulation UGT1A6 PRL 11408524 825959 The data indicated that was able to *increase* expression of [UGT1A6] ( protein and mRNA ) but not 1A1 . Positive_regulation UGT1A6 UGGT2 20551240 2302236 In particular , [Ugt1a6] and Cyp2b1 were *increased* by BNF , Cyp1a1 , Cyp3a1 , and by PB , and Cyp3a1 and Ugt2b1 by CLO . Positive_regulation UGT1A6 UGT2B7 10220484 609224 both [UGT1A6] and UGT1A9 were *induced* by 10 nM TCDD , whereas was not induced by TCDD . Positive_regulation UGT1A7 AHR 9488689 489227 Transcriptional *activation* of the [UDP-glucuronosyltransferase 1A7] gene in rat liver by ligands and oltipraz . Positive_regulation UGT1A7 HNF4A 20406851 2274178 In contrast to liver expressed UGT1A9 , transcriptional *activation* of [UGT1A7] by was lower and dependent on higher HNF4alpha concentrations , which may contribute to the observed differences in tissue expression patterns . Positive_regulation UGT1A7 PLEC 19144771 2048109 In small intestine , the PXR activator *increased* Ugt1a1 , Ugt1a6 , [Ugt1a7] , Ugt2b34 , and Ugt2b35 mRNA in the duodenum . Positive_regulation UGT1A7 VDR 24242708 2897987 Real-Time PCR analysis revealed that *mediated* significant regulation of CYP3A4 , CYP3A5 , CYP3A43 , AKR1C1-3 , [UGT2B15/17] , and HSD17B2 . Positive_regulation UGT2B15 FOXA1 20736324 2345811 *regulates* [UDP-glucuronosyltransferase 2B15] gene transcription in LNCaP prostate cancer cells . Positive_regulation UGT2B15 FOXA1 20736324 2345817 In this study , we show that also *regulates* basal expression of the [UGT2B15] gene in the prostate cell line LNCaP ( lymph node carcinoma of the prostate ) . Positive_regulation UGT2B15 FOXA1 20736324 2345819 Silencing of FOXA1 expression by small interfering RNA significantly reduced UGT2B15 transcript levels , further confirming a crucial *role* of in controlling [UGT2B15] gene expression . Positive_regulation UGT2B7 UGT1A6 19475557 2182565 The thermal stability of [UGT2B7] was significantly *increased* by the coexpressed UGT1A1 , UGT1A4 , , and UGT1A9 , indicating an interaction between UGT2B7 and the UGT1As . Positive_regulation UHRF1 FOXA1 24512546 2914469 Moreover , the expression of XBP1 , MYC , ZBTB16 , and [UHRF1] , which are downstream targets of AR , was *promoted* by up-regulation or inhibited by FOXA1 down-regulation . Positive_regulation ULBP2 EPHB2 19048119 1999270 Furthermore , overexpression of constitutively active in H9 parental cells *resulted* in increased [ULBP-2/ULBP-3] expression and enhanced NK cell lysis . Positive_regulation ULBP2 EPHB2 23308050 2712561 Activation of constitutively phosphorylated extracellular signal regulated kinase ( ) by VPA is *essential* for the up-regulation of MICA/B and [ULBP2] expressions . Positive_regulation ULBP2 EPHB2 23308050 2712565 Furthermore , overexpression of constitutively active in ARK *resulted* in increased MICA/B and [ULBP2] expressions and enhanced NK cell lysis . Positive_regulation ULBP3 EPHB2 19048119 1999271 Furthermore , overexpression of constitutively active in H9 parental cells *resulted* in increased [ULBP-2/ULBP-3] expression and enhanced NK cell lysis . Positive_regulation UMOD EMP1 12010795 941288 The ability of to *induce* [THP-1] procoagulant activity was significantly reduced when THP-1 cells were incubated with EMP in the presence of blocking antibodies against ICAM-1 and beta2 integrins . Positive_regulation UMOD IL1B 18032781 1846469 Furthermore , U46619 enhanced *induced* [THP-1] monocyte binding to VSMCs , which was inhibited by SQ29548 or SP600125 . Positive_regulation UMOD IL1B 19697035 2258165 The level of IL-6 expression was strongly increased in both FLSs and [THP-1] macrophages in *response* to and TNF-alpha , but the level by TNF-alpha was less than that by IL-1beta . Positive_regulation UMOD SELL 10515876 652029 Inhibition of both P- and *reduced* [THP-1/HUVEC] interactions to 14 % ( P < .01 , n = 4 ) . Positive_regulation UMOD TLR7 21567173 2531888 L. donovani induced phosphorylation of P70S6K , a correlate of mTOR activity , in *stimulated* [THP-1] derived macrophages . Positive_regulation UMOD TNF 12058956 952624 An anti-rheumatic agent T-614 inhibits NF-kappaB activation in LPS- and *stimulated* [THP-1] cells without interfering with IkappaBalpha degradation . Positive_regulation UMOD TNF 12421945 1013732 All these treatments prevented CD44 induction in LPS stimulated , but not in *stimulated* , [THP-1] cells . Positive_regulation UMOD TNF 18303186 1873572 *Role* of and extracellular ATP in [THP-1] cell activation following allergen exposure . Positive_regulation UMOD TNF 19106809 2093295 Transfection with TTP siRNA reversed the down-regulation of TLR4 in *stimulated* [THP-1] . Positive_regulation UMOD TNF 19472212 2102232 Furthermore , IFN-gamma synergistically enhanced the production of CXCL10 in parallel with the activation of NF-kappaB in *stimulated* [THP-1] cells . Positive_regulation UMOD TNF 19697035 2258164 The level of IL-6 expression was strongly increased in both FLSs and [THP-1] macrophages in *response* to IL-1beta and , but the level by TNF-alpha was less than that by IL-1beta . Positive_regulation UMOD TNF 20932938 2343352 Preincubation of VSMCs for 2h with diosgenin ( 0.1-10 µM ) dose-dependently inhibited *induced* adhesion of [THP-1] monocytic cells and mRNA and protein expression of vascular cell adhesion molecule-1 ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ) . Positive_regulation UMOD TNF 7684503 219655 DNA mobility shift assay revealed specific binding of nuclear protein ( s ) from LAM- , LPS- , or *stimulated* [THP-1] cells to the NF-IL6 motifs . Positive_regulation UNC13D STAT4 24842371 2940266 Mechanistically , T cell receptor engagement facilitated *dependent* [Munc13-4] expression in naive CD8 ( + ) T lymphocytes . Positive_regulation UNC5B AGAP2 21460185 2433212 Overexpression of *diminishes* [UNC5B] expression through down-regulation of p53 . Positive_regulation UNC5B AGAP2 21460185 2433214 Knocking down stabilizes p53 , *increases* [UNC5B] , and escalates UV-triggered apoptosis . Positive_regulation UNC5B AKT1 21460185 2433202 Here we show that phosphorylates PIKE-A and *regulates* its association with [UNC5B] and inhibits UNC5B provoked apoptosis in a p53 dependent manner . Positive_regulation UNC5B AKT2 21460185 2433203 Here we show that phosphorylates PIKE-A and *regulates* its association with [UNC5B] and inhibits UNC5B provoked apoptosis in a p53 dependent manner . Positive_regulation UNC5B AKT3 21460185 2433204 Here we show that phosphorylates PIKE-A and *regulates* its association with [UNC5B] and inhibits UNC5B provoked apoptosis in a p53 dependent manner . Positive_regulation UNC5B APOB 23599441 2783856 Indeed , using promoter-luciferase reporter genes , we show that Ntn1- and [Unc5b-promoter] activities are *induced* by oxidized low-density and require HIF-1a . Positive_regulation UNC5B HLX 21224470 2397588 This inhibition of sprouting was caused to a significant part by *mediated* up-regulation of [UNC5B] as shown by short hairpin RNA ( shRNA ) -mediated down-modulation of the respective mRNA . Positive_regulation UNC5B LPA 23599441 2783857 Indeed , using promoter-luciferase reporter genes , we show that Ntn1- and [Unc5b-promoter] activities are *induced* by oxidized low-density and require HIF-1a . Positive_regulation UNC5B NTN1 17908930 1803362 *Activation* of the [UNC5B] receptor by inhibits sprouting angiogenesis . Positive_regulation UNC5B NTN1 18469807 1916587 Here we show that *induces* interaction of [UNC5B] with the brain-specific GTPase PIKE-L . Positive_regulation UNC5B NTN1 18469807 1916589 Moreover , this process relies strongly on Fyn because PIKE-L is tyrosine phosphorylated in response to netrin-1 , and the *mediated* interaction of [UNC5B] with PIKE-L is inhibited in Fyn-null mice . Positive_regulation UNC5B NTN1 23526078 2787929 Proliferation of ACHN cells was concentration dependent in the *presence* of PMA and calphostin C . and [UNC5B] expressions were upregulated in cells treated with PMA while calphostin C reversed this upregulation . Positive_regulation UNC5B NTN4 18719102 1955788 Coimmunoprecipitation experiments demonstrated that *increased* the association between [Unc5B] and neogenin on VEGF- or FGF-2 stimulated EC . Positive_regulation UNC5B NTN4 22496621 2583695 The negative effects of on proliferation were *mediated* by [UNC5B] . Positive_regulation UNC5B SETD2 23599441 2783855 Indeed , using promoter-luciferase reporter genes , we show that Ntn1- and [Unc5b-promoter] activities are *induced* by oxidized low-density lipoprotein and require . Positive_regulation UNC5B SETD2 23599441 2783865 These findings provide a molecular mechanism by which netrin-1 and its receptor Unc5b are expressed in atherosclerotic plaques and implicate hypoxia and *induced* [netrin-1/Unc5b] in sustaining inflammation by inhibiting the emigration and promoting the survival of lesional macrophages . Positive_regulation UNC5B TP53 15818407 1425086 The expression of the axon-guidance molecule [UNC5B] ( also designated p53RDL1 ) , which is a receptor for netrin-1 , is directly *regulated* by . Positive_regulation UPP1 TNF 20544543 2271780 Activation of Stat1 , IRF-1 , and NF-kappaB is required for the *induction* of [uridine phosphorylase] by and interferon-gamma . Positive_regulation USF2 IL1B 12225970 987940 USF-1 and [USF-2] trans-repress *induced* iNOS transcription in mesangial cells . Positive_regulation USO1 TP63 16337913 1491372 While both TAp63 and p53 induce similar apoptotic signaling proteins and require BAX expression and function for their effects , [TAp63] induces neuronal death in the absence of p53 , but p53 *requires* coincident expression for its proapoptotic actions . Positive_regulation USP1 CAPN8 23589330 2789543 Here we show that is *required* for the stability of the deubiquitinating enzyme [USP1] in several cell lines . Positive_regulation USP1 CAPN8 23589330 2789557 These data suggest that *stabilizes* [USP1] by activating Cdk5 , which in turn inhibits cdh1 and , consequently , USP1 degradation . Positive_regulation USP11 TNF 17897950 1823992 The deubiquitinating enzyme [USP11] controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in *response* to . Positive_regulation UTP15 PLAT 11372682 817779 The aim of the present study was to investigate whether ATP and [UTP] can *induce* acute release from the vascular endothelium in vivo . Positive_regulation UTP18 PLAT 11372682 817777 The aim of the present study was to investigate whether ATP and [UTP] can *induce* acute release from the vascular endothelium in vivo . Positive_regulation UTP20 PLAT 11372682 817775 The aim of the present study was to investigate whether ATP and [UTP] can *induce* acute release from the vascular endothelium in vivo . Positive_regulation UTP23 PLAT 11372682 817780 The aim of the present study was to investigate whether ATP and [UTP] can *induce* acute release from the vascular endothelium in vivo . Positive_regulation UTP3 PLAT 11372682 817778 The aim of the present study was to investigate whether ATP and [UTP] can *induce* acute release from the vascular endothelium in vivo . Positive_regulation UTP6 PLAT 11372682 817776 The aim of the present study was to investigate whether ATP and [UTP] can *induce* acute release from the vascular endothelium in vivo . Positive_regulation UTRN CAPN8 16598790 1562546 In addition , we showed that activation of cellular calpains by Ca2+ ionophore treatment reduces [utrophin] protein levels in muscle cells and that inhibition *prevents* this Ca2+ -induced reduction in utrophin levels . Positive_regulation UTRN PGC 22253880 2538412 Given that it has been shown that slow fibers produce and maintain more utrophin than fast skeletal muscle fibers , we hypothesized that over-expression of in post-natal mdx mice would *increase* [utrophin] levels via a fiber type shift , resulting in more slow , oxidative fibers that are also more resistant to contraction induced damage . Positive_regulation UTRN PGC 24447845 2912973 We show here that does not *induce* [utrophin] or other neuromuscular genes when transgenically expressed in mouse skeletal muscle . Positive_regulation UTRN ZFP57 18945675 1994832 Expression of one such efficiently *increased* , in a time dependent manner , [utrophin] transcript and protein levels both in vitro and in vivo . Positive_regulation UTS2 EPHB2 12495783 1033480 On the other hand , [UII] *induced* an increase in the phosphorylation level of , but not FAK , in cells adherent to fibronectin . Positive_regulation UVRAG CCL17 18937546 1994665 [p63] *induces* CD4+ T-cell chemoattractant in human epithelial cells . Positive_regulation VAMP3 SYT8 17625073 1829257 Previous studies indicate that the process requires Rab3 dependent tethering of membranes , [SNARE complex] assembly , and Ca2+ mediated *activation* of . Positive_regulation VAMP4 SYT8 17625073 1829275 Previous studies indicate that the process requires Rab3 dependent tethering of membranes , [SNARE complex] assembly , and Ca2+ mediated *activation* of . Positive_regulation VASP ARSA 18563667 1952774 On the other hand , also markedly *increased* levels of NO/cyclic GMP , and cyclic GMP induced [vasodilator stimulated phosphoprotein] phosphorylation . Positive_regulation VAV1 CD22 12421939 1013712 In contrast , negatively *regulates* [Vav] phosphorylation . Positive_regulation VAV1 EPHB2 17119112 1700611 Although RhoH is not required for TCR induced activation of ZAP70 and ZAP70 mediated activation of p38 , it is crucial for the tyrosine phosphorylation of LAT , PLCgamma1 , and [Vav1] and for the *activation* of and calcium influx . Positive_regulation VAV1 ITGAL 12885870 1116787 Using transfected insect cells that express ligands of human NK cell receptors , we show that engagement of the beta2 integrin on NK cells by intercellular adhesion molecule (ICAM)-1 *led* to a tyrosine phosphorylation of [Vav1] that was not sensitive to cholesterol depletion and to inhibition of actin polymerization . Positive_regulation VAV1 ITGB2 14960575 1227750 We have identified Vav , a guanine nucleotide exchange factor for Rac-1 , and PI3K/Akt , as regulators of the activation and inactivation phases of the activity of Rac-1 , respectively , in the context of LFA-1 signaling based on the following experimental evidence : ( i ) *induced* activation of [Vav] and PI3K/Akt with kinetics consistent with a regulatory role for these molecules on Rac-1 , ( ii ) overexpression of a constitutively active Vav mutant induces activation of Rac independently of LFA-1 stimulation whereas overexpression of a dominant negative Vav mutant blocks LFA-1 mediated Rac activation , ( iii ) pharmacological inhibition of PI3K/Akt prevented the fall in the activity of Rac-1 after its initial activation but had no effect on Vav activity , and ( iv ) overexpression of a dominant negative or a constitutively active Akt-1 induced or inhibited , respectively , Rac-1 activity . Positive_regulation VAV1 ITGB2 17624948 1770112 [Vav-1] , a guanine nucleotide exchange factor for Rho proteins , is activated as a *consequence* of engagement . Positive_regulation VAV1 ITGB2 22177564 2518370 Both Mac-1 activation and Dectin-1- and induced neutrophil effector functions *require* [Vav1] and Vav3 , exchange factors for RhoGTPases . Positive_regulation VAV3 ITGB2 22177564 2518372 Both Mac-1 activation and Dectin-1- and induced neutrophil effector functions *require* Vav1 and [Vav3] , exchange factors for RhoGTPases . Positive_regulation VCAM1 AXIN2 18951693 2014599 Wnt pathway inhibitors , ( intracellular ) or Dickkopf-1 ( extracellular ) *blocked* the regulation of [VCAM-1] by diffusible Wnt3a . Positive_regulation VCAM1 CD14 11243109 479755 The expression of was increased and the expressions of MHC-II , B7-1 , B7-2 and [VCAM-1] were also *up-regulated* . Positive_regulation VCAM1 DAPK1 22868392 2671620 In human umbilical vein endothelial cells , expressions of [vascular cell adhesion molecule 1] , endothelial selectin , and cyclooxygenase 2 , as well as ROS production induced by tumor necrosis factor-a , were *inhibited* by inhibitor . Positive_regulation VCAM1 EDN2 10206185 606475 In the present study , alone did not induce the surface expression and mRNA accumulation of VCAM-1 in human vascular endothelial cells , but inhibition of endogenous nitric oxide ( NO ) by N ( G ) -monomethyl-L-arginine *enhanced* the surface expression and mRNA accumulation of [VCAM-1] stimulated by endothelin-1 . Positive_regulation VCAM1 EDN2 10206185 606486 These findings suggest that the synergistic *enhancement* of [VCAM-1] expression by TNF-alpha and ET ( B ) receptor stimulation may be augmented by the induction of NF-kappaB binding activity in human vascular endothelial cells . Positive_regulation VCAM1 EPHB2 17292586 1725835 TNFR1 induced NF-kappaB , but not , p38MAPK or JNK activation , *mediates* TNF induced ICAM-1 and [VCAM-1] expression on endothelial cells . Positive_regulation VCAM1 EPHB2 18656701 1942689 Selective inhibitors of p38 MAPK ( SB203580 ) , JNK ( SP600125 ) and ERK ( PD98059 ) could suppress TNF-alpha induced CCL2 and ICAM-1 expression , while only p38 MAPK and inhibitors could *suppress* TNF-alpha induced [VCAM-1] expression . Positive_regulation VCAM1 EPHB2 19609071 2112268 The Cd-induced [VCAM-1] expression was significantly *suppressed* by either a specific p38 mitogen activated protein kinase (MAPK) inhibitor ( SB202190 ) or a JNK inhibitor ( SP600125 ) , but not by an inhibitor ( U0126 ) . Positive_regulation VCAM1 EPHB2 22842465 2646578 Omentin , NF-kB inhibitor ( BAY11-7082 ) and inhibitor ( PD98059 ) *reduced* the up-regulation of ICAM-1 and [VCAM-1] induced by TNF-a . Positive_regulation VCAM1 F2R 23352962 2754149 MAb 8E8 or agonist peptide *stimulated* IL-6 and IL-8 production and [VCAM-1] expression in HPMEC-ST1.6R cells . Positive_regulation VCAM1 HES2 16247329 1471613 After stimulation with IL-1 ( 10 U/mL ) , *had* no effect on the expression of P-selectin , E-selectin , ICAM-1 , or [VCAM-1] . Positive_regulation VCAM1 IL1B 10233853 611728 Fibroblast-like synoviocytes rapidly up-regulate [VCAM-1] expression in *response* to and TNF-alpha , but also to IL-4 . Positive_regulation VCAM1 IL1B 10382751 624351 PDTC treated mice survived despite high and IL-6 levels , *induction* of [VCAM-1] and ICAM-1 expression or leukocyte infiltration in tissues known to be associated with LPS induced shock , indicating that PDTC does not act by modifying these responses . Positive_regulation VCAM1 IL1B 10430178 633562 TNF-alpha and *stimulated* cell surface ICAM-1 expression , but not [VCAM-1] expression , in human aortic smooth muscle cells ( HASMCs ) . Positive_regulation VCAM1 IL1B 10497254 647500 Adenovirus mediated overexpression of a dominant negative IkappaBalpha ( inhibitor of kappaB ) mutant blocked NF-kappaB activation by gel shift assay and blocked *induction* of [vascular cell adhesion molecule-1] protein by TNF-alpha , , and LPS , a NF-kappaB dependent response . Positive_regulation VCAM1 IL1B 10559516 566638 Enrichment of HAEC with the same doses of vitamin E suppressed *stimulated* expression of intercellular adhesion molecule-1 ( ICAM-1 ) , [vascular cell adhesion molecule-1] ( VCAM-1 ) , and endothelial leukocyte adhesion molecule-1 ( E-selectin ) . Positive_regulation VCAM1 IL1B 10573217 568778 ( optimal concentration ( OC ) 1 U x mL(-1) ) and TNFalpha ( OC 100 U x mL(-1) ) both *increased* ICAM-1 and [VCAM-1] expression . Positive_regulation VCAM1 IL1B 10678917 668321 Expression of [VCAM-1] was *mediated* not only by TNF-alpha but also by IL-1alpha and , all of which were synthesized by endothelial cells in response to C. albicans . Positive_regulation VCAM1 IL1B 10807407 692190 The expression of CD11b and CD18 on neutrophils and neutrophil dependent adhesion to endothelial cells elicited by HPE were inhibited by lansoprazole and omeprazole at clinical relevant doses , and the expression of ICAM-1 and [VCAM-1] on endothelial cells and endothelial dependent neutrophil adherence *induced* by were also inhibited by lansoprazole and omeprazole at similar doses . Positive_regulation VCAM1 IL1B 10833420 697691 K-7174 inhibited the expression of [vascular cell adhesion molecule-1] ( VCAM-1 ) *induced* by either tumor necrosis factor alpha or , without affecting the induction of intercellular adhesion molecule-1 or E-selectin . Positive_regulation VCAM1 IL1B 10886302 709678 Upon *stimulation* with the expression of E-selectin , [VCAM-1] and ICAM-1 ( CD54 ) was upregulated . Positive_regulation VCAM1 IL1B 10886302 709681 The expression of E-selectin and [VCAM-1] , which are not constitutively expressed on the cell lines , can be induced by *stimulation* of the endothelial cells with . Positive_regulation VCAM1 IL1B 10900176 712703 DPI also inhibited TNF and LPS induced VCAM-1 and ICAM-1 cell surface expression and TNF- alpha , LPS , or *induced* [VCAM-1] and ICAM-1 mRNA accumulation . Positive_regulation VCAM1 IL1B 11403206 824951 ICAM-1 , [VCAM-1] , and E-selectin expression were all *stimulated* by both and TNF-alpha in the 24 h assays . Positive_regulation VCAM1 IL1B 11702679 878843 ( 3 ) The expression rate of VCAM-1 in VECs increased significantly after interleukin-1 beta acted on the cells ( 17.5 % +/- 1.5 % ) . 17-beta estradiol at the contents of 3 x 10 ( -8 ) -10 ( -6 ) mol/L all counteracted the increase in expression rate of [VCAM-1] *induced* by ( 15.4 % +/- 1.42 % , 12.4 % +/- 0.34 % , 8.7 % +/- 0.27 % , P < 0.01 ) . Positive_regulation VCAM1 IL1B 11961404 932605 Furthermore , SIN-1 and NP inhibited the [VCAM-1] mRNA expression *induced* by or lipopolysaccharide as well . Positive_regulation VCAM1 IL1B 12115600 964175 Indeed , addition of hyperosmotic , pathophysiologically relevant concentrations of NaCl effectively inhibited or TNF-alpha *induction* of [VCAM-1] , but not E-selectin , at the level of mRNA and cell surface protein . Positive_regulation VCAM1 IL1B 12121710 965083 Effects of estrogen , progesterone , and combination exposure on *induced* expression of [VCAM-1] , ICAM-1 , PECAM , and E-selectin by human female iliac artery endothelial cells . Positive_regulation VCAM1 IL1B 12121710 965084 Pretreatment with estrogen or progesterone alone decreased *stimulated* [VCAM-1] and ICAM-1 expression , but not to statistically significant levels . Positive_regulation VCAM1 IL1B 12124212 965696 Because IL-18 is a proinflammatory cytokine known to mediate the production of TNF-alpha and and to *induce* the expression of intercellular adhesion molecule-1 ( ICAM-1 ) and [vascular cell adhesion molecule-1] ( VCAM-1 ) , we hypothesized that neutralization of IL-18 would attenuate lipopolysaccharide (LPS) induced cardiac dysfunction . Positive_regulation VCAM1 IL1B 12191851 980658 In all preparations of HUVECs used in this study , RT-PCR confirmed mRNA expression of both isoforms of PR , PR-A and PR-B , as well as AR. Addition of progesterone ( 10 ( -10 ) -10 ( -7 ) M ) or dienogest ( DNG ) ( 10 ( -10 ) -10 ( -8 ) M ) did not affect *stimulated* ICAM-1 or [VCAM-1] expression . Positive_regulation VCAM1 IL1B 15001568 1236964 The present study examined the effect of angiotensin II on *induced* NF-kappaB activation and the subsequent expression of inducible NO synthase (iNOS) and [vascular cell adhesion molecule-1] ( VCAM-1 ) in cultured rat vascular smooth muscle cells . Positive_regulation VCAM1 IL1B 15033450 1223449 EGCG also inhibited the *induced* induction of [VCAM-1] expression . Positive_regulation VCAM1 IL1B 15186945 1256277 Pre-incubation of HAEC with AEM at 20 and 40 microg/ml , but not at 4 microg/ml , for 24h significantly suppressed *stimulated* expressions of intracellular adhesion molecule-1 ( ICAM-1 ) , [vascular cell adhesion molecule-1] ( VCAM-1 ) , and E-selectin and the secretion of proinflammatory cytokines IL-6 , chemokines IL-8 and monocyte chemoattractant protein (MCP)-1 . Positive_regulation VCAM1 IL1B 15489374 1359412 Involvement of p42/p44 MAPK , p38 MAPK , JNK , and NF-kappaB in *induced* [VCAM-1] expression in human tracheal smooth muscle cells . Positive_regulation VCAM1 IL1B 15489374 1359413 Here , the roles of mitogen activated protein kinases ( MAPKs ) and nuclear factor-kappaB (NF-kappaB) pathways for *induced* [vascular cell adhesion molecule (VCAM)-1] expression were investigated in human tracheal smooth muscle cells ( HTSMC ) . Positive_regulation VCAM1 IL1B 15489374 1359415 *induced* expression of [VCAM-1] protein and mRNA in a time dependent manner , which was significantly inhibited by inhibitors of MEK1/2 ( U0126 and PD-98059 ) , p38 ( SB-202190 ) , and c-Jun NH ( 2 ) -terminal kinase ( JNK ; Positive_regulation VCAM1 IL1B 15489374 1359431 *induced* [VCAM-1] expression was significantly blocked by the specific NF-kappaB inhibitors helenalin and pyrrolidine dithiocarbamate . Positive_regulation VCAM1 IL1B 15489374 1359441 Together , these results suggest that in HTSMC , activation of p42/p44 MAPK , p38 , JNK , and NF-kappaB pathways is essential for *induced* [VCAM-1] gene expression . Positive_regulation VCAM1 IL1B 15720567 1376529 Although TNF-alpha and , at concentrations a little higher than those in sera of periodontitis patients , *up-regulated* the expression of intercellular adhesion molecule-1 and [vascular cell adhesion molecule-1] , P. gingivalis antigens had only a slight stimulatory effect . Positive_regulation VCAM1 IL1B 15797891 1403772 In cultured tubular epithelial cells , rosiglitazone significantly decreased the expression of ICAM-1 and [VCAM-1] *induced* by TNF-alpha or , inhibited the degradation of inhibitor kappaBalpha ( IkappaBalpha ) and blocked the activation of the p65 subunit of nuclear factor (NF)-kappaB . Positive_regulation VCAM1 IL1B 15830921 1394436 All-trans-retinoic acid ( tRA ) modulates in human mesangial cells ( MC ) antioxidant defenses , the expression of *induced* [vascular cell-adhesion molecule-1] ( VCAM-1 ) , cyclooxygenase-2 (COX-2) , and the retinoic acid-receptor-beta (RAR-beta) . Positive_regulation VCAM1 IL1B 16249517 1471759 Stimulation of hRVECs with VEGF ( 165 ) , TNFalpha , or for 6 to 24 hours *caused* significant induction of intracellular adhesion molecule (ICAM)-1 and [vascular cell adhesion molecule (VCAM)-1] expression . Positive_regulation VCAM1 IL1B 16601113 1568698 Overexpression of GSK-3beta in endothelial cells , in contrast , significantly inhibited ( by 70 % , p < 0.01 ) both TNF-alpha and *induced* expression of IL-6 , MCP-1 , and [vascular cell adhesion molecule-1] . Positive_regulation VCAM1 IL1B 17349082 1707995 In the present study , we investigated the effects of EA on the formation of intracellular reactive oxygen species , the translocation of NFkappaB and expression of [vascular cell adhesion molecule-1] ( VCAM-1 ) , intercellular adhesion molecule-1 and endothelial leucocyte adhesion molecule ( E-selectin ) *induced* by in human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation VCAM1 IL1B 17885219 1823785 Furthermore , silencing of MK2 in endothelial cells by siRNA reduced the *induced* expression of [VCAM-1] and MCP-1 . Positive_regulation VCAM1 IL1B 18032781 1846464 Activation of thromboxane receptor upregulates *induced* [VCAM-1] expression through JNK signaling . Positive_regulation VCAM1 IL1B 18032781 1846465 This study examined how activation of TPr modulates *induced* [vascular cell adhesion molecule (VCAM)-1] expression in aortic vascular smooth muscle cells ( VSMCs ) . Positive_regulation VCAM1 IL1B 18032781 1846471 This study demonstrates that activation of TPr upregulates *induced* [VCAM-1] expression by enhancing the activation of JNK pathway that leads to enhanced AP-1 activation . Positive_regulation VCAM1 IL1B 19229069 2054617 Neutralization of the IL-8 receptor , CXCR2 , further induced VCAM-1 in the *presence* of , and phospho-p38 was required for NF-kappaB activation and [VCAM-1] expression . Positive_regulation VCAM1 IL1B 19281832 2072885 Here , we investigated the mechanisms underlying *induced* [VCAM-1] expression in human tracheal smooth muscle cells ( HTSMCs ) . Positive_regulation VCAM1 IL1B 19281832 2072888 These findings suggested that *induced* [VCAM-1] expression via these multiple signaling pathways in HTSMCs . Positive_regulation VCAM1 IL1B 19446813 2141900 Digitoxin , employing therapeutical concentrations used in patients ( 3-30nM ) , potently inhibited the *induced* expression of MCP-1 and [VCAM-1] in EC and the capacity of corresponding cell culture supernatants on monocyte migration as well as monocyte adhesion to endothelial monolayers , respectively . Positive_regulation VCAM1 IL1B 19937041 2280700 Chlorogenic acid dose-dependently suppressed *induced* mRNA expression of [vascular cell adhesion molecule-1] , intercellular cell adhesion molecule-1 and endothelial cell selectin . Positive_regulation VCAM1 IL1B 7511198 250043 Estradiol-17 beta regulates the *induction* of [VCAM-1] mRNA expression by in human umbilical vein endothelial cells . Positive_regulation VCAM1 IL1B 7511198 250044 In conclusion , estradiol-17 beta regulates the *induction* of [VCAM-1] gene expression by in human umbilical vein endothelial cells . Positive_regulation VCAM1 IL1B 7529998 291551 Here , we demonstrate that TNF-alpha and transiently *induced* [VCAM-1] mRNA expression in a time dependent manner . Positive_regulation VCAM1 IL1B 7537041 300337 Tumor necrosis factor alpha and but not interferon gamma *induce* [vascular cell adhesion molecule-1] expression on primary cultured murine hepatocytes . Positive_regulation VCAM1 IL1B 7537041 300342 TNF alpha and but not IFN gamma or IL-6 *induced* [VCAM-1] expression on primary cultured murine hepatocytes in a dose- and a time dependent fashion . Positive_regulation VCAM1 IL1B 7538427 301292 In parallel , DHA inhibited TNF-alpha stimulated monocytic U937 cell adhesion to HUVECs but did not affect TNF-alpha- or interferon gamma induced expression of intercellular adhesion molecule-1 and endothelial leukocyte adhesion molecule-1 or [VCAM-1] *induction* by . Positive_regulation VCAM1 IL1B 7545398 318538 The *induced* expression of intercellular adhesion molecule 1 ( ICAM-1 ) , [vascular cell adhesion molecule 1] ( VCAM-1 ) and E-selectin 1 ( ELAM-1 ) on SMCs was examined by reverse transcription/polymerase chain reaction ( RT/PCR ) . Positive_regulation VCAM1 IL1B 7556162 327623 Although [VCAM-1] is also *induced* by the cytokine , activation of the dsRNA activated protein kinase ( PKR ) occurs only in response to incubation with dsRNA but not with IL-1 beta . Positive_regulation VCAM1 IL1B 7691889 231023 In cultured human umbilical vein endothelial ( HUVE ) cells , the cytokine *activated* [VCAM-1] gene expression through a mechanism that was repressed approximately 90 % by the antioxidants pyrrolidine dithiocarbamate ( PDTC ) and N-acetylcysteine (NAC) . Positive_regulation VCAM1 IL1B 8639172 362510 We found that AECA IgG from WG patients do not display any significant cytotoxicity but are able to up-regulate the expression of E-selectin , intercellular adhesion molecule 1 and [vascular cell adhesion molecule 1] and to *induce* the secretion of , IL-6 , IL-8 , and MCP-1 . Positive_regulation VCAM1 IL1B 8649360 366480 D609 , a phosphatidylcholine-specific phospholipase C inhibitor , blocks *induced* [vascular cell adhesion molecule 1] gene expression in human endothelial cells . Positive_regulation VCAM1 IL1B 8866792 344797 In previous studies we have shown that and TNF-alpha *increase* the expression of ICAM-1 , E-selectin and [VCAM-1] on the cytoplasmatic membranes of HUVECs , HSVECs and HAFECs ( ECs from human umbilical vein , saphenous vein and femoral artery , respectively ) . Positive_regulation VCAM1 IL1B 9008098 405035 Cell surface enzyme immunoassay showed that INFnu , , or TNF alpha *stimulated* expression of ICAM-1 , or [VCAM-1] on MC after 24 hours . Positive_regulation VCAM1 IL1B 9047077 406001 Both ICAM-1 and [VCAM-1] expression were *increased* markedly by . Positive_regulation VCAM1 IL1B 9047077 406003 This *mediated* induction of ICAM-1 and [VCAM-1] expression was significantly inhibited in the presence of a NO donor 3-morpholino-sydnonimine ( SIN-1 ) in a dose dependent manner . Positive_regulation VCAM1 IL1B 9047077 406005 The inhibitory effect of SIN-1 was abolished in the presence of a NO scavenger haemoglobin , while addition of 8-bromo-cGMP showed no significant effect on *induced* ICAM-1 or [VCAM-1] expression . Positive_regulation VCAM1 IL1B 9047077 406007 Northern blot analysis showed that markedly *increased* ICAM-1 and [VCAM-1] mRNA expression , while SIN-1 decreased the accumulation of these transcripts induced by IL-1 beta . Positive_regulation VCAM1 IL1B 9120300 423849 In this study , we examined the effects of 5-lipoxygenase inhibitors ( nordihydroguaiaretic acid and AA861 ) on *induced* [VCAM-1] gene expression in HUVECs . Positive_regulation VCAM1 IL1B 9120300 423851 We demonstrated that 5-lipoxygenase inhibitors , but not cyclooxygenase inhibitors , block *induced* [VCAM-1] cell surface expression and promoter activity . Positive_regulation VCAM1 IL1B 9409229 471390 In cultured human smooth muscle cells from coronary arteries and saphenous veins , tumor necrosis factor-alpha (TNF-alpha) and *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular cell adhesion molecule ( [VCAM-1] ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation VCAM1 IL1B 9409229 471438 Cicaprost as well as forskolin significantly inhibited TNF-alpha- and *induced* cell surface expression of ICAM-1 and [VCAM-1] . Positive_regulation VCAM1 IL1B 9448041 483777 TNF-alpha and *increased* the expression of ICAM-1 , E-selectin , and [VCAM-1] , whereas IL-4 induced only that of VCAM-1 . Positive_regulation VCAM1 IL1B 9523024 493877 Coincubation of neutrophils with alpha-Toc and pretreatment of HUVEC with alpha-Toc significantly reduced PAF induced CD11b/CD18 expression and *induced* upregulation of ICAM-1 and [VCAM-1] , respectively . Positive_regulation VCAM1 IL1B 9537837 492367 Astroglioma cell lines as well as primary human fetal astrocytes expressed low levels of [VCAM-1] constitutively , and the proinflammatory cytokines *induced* marked increases in VCAM-1 expression , particularly TNF-alpha and . Positive_regulation VCAM1 IL1B 9663488 518379 and tumor necrosis factor alpha (TNFalpha) further *induced* [VCAM-1] and ICAM-1 messenger RNA and protein expression . Positive_regulation VCAM1 ITGB2 11598192 870525 SDF-1alpha triggered a transient regulation of adhesion to intercellular adhesion molecule-1 ( ICAM-1 ) and [vascular cell adhesion molecule-1] *mediated* by and very late antigen-4 (VLA-4) , respectively , and a rapid increase in LFA-1 binding to soluble ICAM-1 . Positive_regulation VCAM1 ITGB2 15096659 1238895 The present study revealed that pioglitazone can influence monocyte-EC binding by *inhibiting* [VCAM-1] expression on activated EC and neutrophil-EC binding by inhibiting upregulation of on activated neutrophils . Positive_regulation VCAM1 ITGB2 9523024 493865 PAF *induced* upregulation of CD11b and on neutrophils and IL-1 beta increased surface expression of ICAM-1 and [VCAM-1] on HUVEC . Positive_regulation VCAM1 MAP2K6 17100776 1644846 However , and c-Jun NH2-terminal kinase (JNK) inhibitor *enhanced* only [VCAM-1] expression on HGF . Positive_regulation VCAM1 PECAM1 19714308 2127452 Significant radiation induced increase of ICAM-1 ( intercellular adhesion molecule-1 ) , [VCAM-1] ( vascular cell adhesion molecule-1 ) , JAM-1 ( junctional adhesion molecule-1 ) , beta1-integrin , beta2-integrin , E-cadherin , and P-selectin gene expression could be *detected* in vivo , while ( platelet-endothelial cell adhesion molecule-1 ) gene expression remained unchanged . Positive_regulation VCAM1 PECAM1 9506571 491438 In early lesions , expression of , ICAM-1 , ICAM-2 , and P-selectin was similar to that in control samples , and [VCAM-1] and E-selectin were *induced* in vascular endothelium . Positive_regulation VCAM1 SELL 7690868 228658 These results show for the first time ( a ) endothelial [vascular cell adhesion molecule-1] induction in various glomerulonephritides and ( b ) *induction* in the kidney . Positive_regulation VCAM1 SPHK1 15191888 1295216 We further investigated the *role* of in TNF-alpha induced expression of inflammatory genes , such as monocyte chemoattractant protein-1 ( MCP-1 ) and [VCAM-1] by using small interfering RNA ( siRNA ) specifically for SphK1 . Positive_regulation VCAM1 TNF 10100995 601953 Kinetic analysis of the ability of FP to inhibit VCAM-1 expression revealed that preincubation with FP for 3 h completely inhibited [VCAM-1] expression *induced* by . Positive_regulation VCAM1 TNF 10100995 601954 Using Northern blot analysis , we confirmed inhibition of VCAM-1 and ICAM-1 messenger RNA ( mRNA ) expression by FP. Pretreatment with FP ( 10 ( -11 ) M to about 10 ( -7 ) M , 24 h ) inhibited *induced* [VCAM-1] mRNA expression in BEAS-2B in a dose dependent manner , but did not inhibit expression of ICAM-1 mRNA . Positive_regulation VCAM1 TNF 10100995 601955 FP ( 10 ( -7 ) M ) also inhibited [VCAM-1] mRNA expression *induced* by in primary human bronchial epithelial cells as assessed by reverse transcription-polymerase chain reaction . Positive_regulation VCAM1 TNF 10102704 602365 The augmented TNF-alpha induced NF-kappaB activation in HG was associated with increased mediated transcriptional *activation* of the [vascular cell adhesion molecule-1] promoter . Positive_regulation VCAM1 TNF 10192291 603644 Correspondingly , a strong reduction of *induced* [VCAM-1] but not ICAM-1 cell surface expression on HPAEC was observed . Positive_regulation VCAM1 TNF 10192291 603647 We conclude that positively charged liposome preparations may per se inhibit *induced* endothelial [VCAM-1] expression , and this may be related to changes in AP-1 but not NF-kappaB dependent transcriptional control . Positive_regulation VCAM1 TNF 10199816 605357 also significantly *enhanced* surface expression of [vascular cell adhesion molecule 1] and E-selectin ( in HUVEC only ) , as well as intercellular adhesion molecule 1 ( ICAM-1 ; in HUVEC and ECV ) . Positive_regulation VCAM1 TNF 10206185 606484 These findings suggest that the synergistic *enhancement* of [VCAM-1] expression by and endothelin ET ( B ) receptor stimulation may be augmented by the induction of NF-kappaB binding activity in human vascular endothelial cells . Positive_regulation VCAM1 TNF 10233853 611727 Fibroblast-like synoviocytes rapidly up-regulate [VCAM-1] expression in *response* to IL-1beta and , but also to IL-4 . Positive_regulation VCAM1 TNF 10339475 615853 We found that overexpression of IkappaB-alpha in endothelial cells using a recombinant adenovirus prevented tumor necrosis factor-alpha (TNF-alpha) induced degradation of IkappaB-alpha and suppressed the *upregulation* of [vascular cell adhesion molecule-1] ( VCAM-1 ) , intercellular adhesion molecule-1 ( ICAM-1 ) , and E-selectin mRNA and surface protein expression and the upregulation of transcripts for the chemokines monocyte chemoattractant protein 1 ( MCP-1 ) and growth related activity-alpha ( GRO-alpha ) by . Positive_regulation VCAM1 TNF 10362686 620126 Hypoxia ( 95 % N2-5 % CO2 ) resulted in a downregulation of basal but not *induced* expression of ICAM-1 and [VCAM-1] . Positive_regulation VCAM1 TNF 10377075 623611 Pretreatment of cultured human ECs with the PPARalpha activators fenofibrate or WY14643 inhibited *induced* [VCAM-1] in a time- and concentration dependent manner , an effect not seen with PPARgamma activators . Positive_regulation VCAM1 TNF 10430178 633559 *induced* both [VCAM-1] and ICAM-1 expression in human umbilical vein endothelial cells ( HUVECs ; Positive_regulation VCAM1 TNF 10430178 633561 and interleukin-1beta (IL-1beta) *stimulated* cell surface ICAM-1 expression , but not [VCAM-1] expression , in human aortic smooth muscle cells ( HASMCs ) . Positive_regulation VCAM1 TNF 10443926 635850 Cells with marked depletion of cytoplasmic GSH , but with an intact pool of mitochondrial GSH , only slightly enhanced *induced* E-selectin and [vascular cell adhesion molecule-1] ( VCAM-1 ) expression , compared with the control . Positive_regulation VCAM1 TNF 10484438 644092 The dual radiolabeled monoclonal antibody technique was used to quantify constitutive and *induced* expression of intercellular adhesion molecule 1 ( ICAM-1 ) , [vascular cell adhesion molecule 1] ( VCAM-1 ) , ICAM-2 , P-selectin , E-selectin , and platelet-endothelial cell adhesion molecule 1 ( PECAM-1 ) in different vascular beds of normal ( C57Bl/6 ) and RM-1 tumor bearing mice . Positive_regulation VCAM1 TNF 10491002 645876 and IL-1 sequentially *induce* endothelial ICAM-1 and [VCAM-1] expression in MRL/lpr lupus-prone mice . Positive_regulation VCAM1 TNF 10497254 647499 Adenovirus mediated overexpression of a dominant negative IkappaBalpha ( inhibitor of kappaB ) mutant blocked NF-kappaB activation by gel shift assay and blocked *induction* of [vascular cell adhesion molecule-1] protein by , IL-1beta , and LPS , a NF-kappaB dependent response . Positive_regulation VCAM1 TNF 10573217 568777 IL-1beta ( optimal concentration ( OC ) 1 U x mL(-1) ) and ( OC 100 U x mL(-1) ) both *increased* ICAM-1 and [VCAM-1] expression . Positive_regulation VCAM1 TNF 10576620 569494 We demonstrate here that out of three compounds , viz diferuloylmethane , p-coumaroylferuloylmethane and di-p-coumaroylmethane , present in the ethyl acetate extract of Curcuma longa , diferuloylmethane is most potent in inhibiting *induced* expression of ICAM-1 , [VCAM-1] and E-selectin on human umbilical vein endothelial cells . Positive_regulation VCAM1 TNF 10600091 573810 We examined the effects of estrogen on *induced* expression of intracellular adhesion molecule ( ICAM-1 ) and vascular adhesion molecule ( [VCAM-1] ) in cultured human bronchial smooth muscle cells ( BSMC ) . Positive_regulation VCAM1 TNF 10626906 576316 The addition of troglitazone to HUVECs significantly reduced the expression of ICAM-1 , [VCAM-1] and E-selectin *induced* by alone or in combination with oxidized LDL ( p < 0.001 ) ; Positive_regulation VCAM1 TNF 10638837 576813 Significant differences were found in the ability to respond to cytokines between HUVEC and the cell lines , the greatest differences being induction of [VCAM-1] and E-selectin in *response* to and induction of MHC class II antigens in response to IFN-gamma . Positive_regulation VCAM1 TNF 10645917 661778 In endothelial cells , the PPARgamma agonists troglitazone at 100 micromol/L and 15-deoxy- ( Delta12,14 ) -prostaglandin J ( 2 ) ( 15d-PGJ2 ) at 20 micromol/L markedly attenuated the *induced* expression of [VCAM-1] and ICAM-1 . Positive_regulation VCAM1 TNF 10678917 668319 Expression of [VCAM-1] was *mediated* not only by but also by IL-1alpha and IL-1beta , all of which were synthesized by endothelial cells in response to C. albicans . Positive_regulation VCAM1 TNF 10734000 678598 We therefore investigated the *role* of in the expression and release of [vascular cell adhesion molecule-1] ( VCAM-1 ) in cultures of human cerebral endothelial cells ( HCEC ) in comparison with peripheral blood mononuclear cells ( PBMC ) . Positive_regulation VCAM1 TNF 10734000 678600 *induced* release of soluble [VCAM-1] was further increased by cotreatment with interferon-beta (IFN-beta) , while IFN-beta alone did not affect VCAM-1 expression or the release of soluble VCAM-1 . Positive_regulation VCAM1 TNF 10807781 692331 *induced* the expression of [VCAM-1] , E-selectin , and ICAM-1 but had no effect on P-selectin expression . Positive_regulation VCAM1 TNF 10820282 694445 These results indicate that NF-kappa B mediates *induced* [VCAM-1] expression on mFLS . Positive_regulation VCAM1 TNF 10892347 711286 *Induction* of [VCAM-1] and ICAM-1 surface expression by was dose-dependently reduced by pycnogenol . Positive_regulation VCAM1 TNF 10900176 712702 DPI also inhibited TNF and LPS induced [VCAM-1] and ICAM-1 cell surface expression and , LPS , or IL-1 beta *induced* VCAM-1 and ICAM-1 mRNA accumulation . Positive_regulation VCAM1 TNF 10918504 717000 Therefore , we examined the effect of NFkappaB decoy ODN transfection on *induced* endogenous interleukin (IL)-1alpha , IL-1beta , IL-6 , ICAM-1 and [VCAM-1] gene expression as assessed by RT-PCR and Northern blotting . Positive_regulation VCAM1 TNF 10975537 729351 High-dose MP reduced the *induced* ICAM-1 and [VCAM-1] expression . Positive_regulation VCAM1 TNF 10996603 733890 In addition , they suppressed interleukin-1beta- or *induced* expression of E-selectin , [vascular cell adhesion molecule-1] ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ) on the surface of the endothelial cells . Positive_regulation VCAM1 TNF 11006011 735172 and LTalpha1beta2 both *increased* the expression of [VCAM-1] and ICAM-1 on FDC-LC . Positive_regulation VCAM1 TNF 11137089 769913 The preoperative HDL ( 3 ) and postoperative , SAA enriched HDL ( 3 ) were identical in terms of their ability to inhibit the *induced* expression of [VCAM-1] in human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation VCAM1 TNF 11137089 769914 This in vitro SAA enriched HDL ( 3 ) inhibited the *induced* expression of [VCAM-1] in HUVECs in a concentration dependent manner , which was identical to that of the unmodified HDL ( 3 ) . Positive_regulation VCAM1 TNF 11156860 780653 Progesterone clearly inhibited *activated* expression of [VCAM-1] protein and its mRNA in HUVECs . Positive_regulation VCAM1 TNF 11156860 780654 Synthetic progesterone receptor agonist R5020 also inhibited the *activated* [VCAM-1] expression , whereas medroxyprogesterone acetate ( MPA ) failed to do so . Positive_regulation VCAM1 TNF 11162639 782335 Since hyperhomocysteinemia appears to be an independent risk factor for the development of atherosclerosis , in this study we investigated the effect of homocysteine on basal and *induced* expression of intercellular adhesion molecule-1 ( ICAM-1 ) , [vascular cell-adhesion molecule-1] ( VCAM-1 ) , and endothelial leukocyte adhesion molecule-1 ( E-selectin ) on human umbilical-vein endothelial cells . Positive_regulation VCAM1 TNF 11162639 782338 Incubation of endothelial cells with homocysteine resulted in dose dependent reduction in *induced* ( 5 ng/ml ) expression of [VCAM-1] , E-selectin , and ICAM-1 ( the latter less pronounced ) . Positive_regulation VCAM1 TNF 11216853 785874 We evaluated the effects of grape seed proanthocyanidin extract ( GSPE ) on the expression of *induced* ICAM-1 and [VCAM-1] expression in primary human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation VCAM1 TNF 11216853 785876 GSPE at low concentrations ( 1-5 micrograms/ml ) , down-regulated *induced* [VCAM-1] expression but not ICAM-1 expression in HUVEC . Positive_regulation VCAM1 TNF 11225735 580981 NF-kappaB activation was greatly potentiated by increased 15-LO activity in the stably transduced cells , and both [VCAM-1] and ICAM-1 were significantly induced in these cells in *response* to and phorbol 12-myristate 13-acetate ( PMA ) stimulation , as studied by flow cytometry . Positive_regulation VCAM1 TNF 11243852 792248 Hematein dose dependently suppressed *induced* [VCAM-1] in both surface ( 30.8 % ) and soluble protein ( 65 % ) production in HUVECs . Positive_regulation VCAM1 TNF 11300880 803295 A thieno [ 2,3-d ] pyrimidine , A-155918 , was identified from a whole-cell high-throughput assay for compounds which inhibited the *induced* expression of E-selectin , ICAM-1 , or [VCAM-1] on human vascular endothelial cells . Positive_regulation VCAM1 TNF 11322336 291246 Binding experiments using both 51Cr labelled lymphocytes , for quantitative analysis , and scanning electron microscopy demonstrated that increased expression of ICAM-1 and [VCAM-1] on the surface of Sertoli cells , *induced* by , determines an augmented adhesion between the two cell types . Positive_regulation VCAM1 TNF 11325610 807377 Again , 7-ketocholesterol did not affect the [VCAM-1] mRNA level , which was *enhanced* by . Positive_regulation VCAM1 TNF 11334881 809264 This study ascertained that tilianin ( 100 microM ) , a major component of A. rugosa , inhibits the *induced* expression of [VCAM-1] by 74 % in cultured human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation VCAM1 TNF 11340302 812463 Of importance , NFkappaB , but not scrambled decoy ODN , significantly attenuated the increase in RNA and protein levels of IL-1alpha , IL-1beta , IL-6 , ICAM-1 and [VCAM-1] *induced* by assessed by RT-PCR . Positive_regulation VCAM1 TNF 11359843 816418 I kappa B kinase is critical for *induced* [VCAM1] gene expression in renal tubular epithelial cells . Positive_regulation VCAM1 TNF 11359843 816422 Two NF-kappaB binding sites in the VCAM1 promoter are critical for the *induced* [VCAM1] transcriptional up-regulation , and both sites bind to p65-p50 NF-kappaB complexes . Positive_regulation VCAM1 TNF 11367519 816873 On human dermal microvascular endothelial cells ( HDMEC ) , griseofulvin inhibited the expression of *induced* [VCAM-1] dose-dependently , and this inhibition was fully reversible . Positive_regulation VCAM1 TNF 11397697 823818 Function of GATA transcription factors in *induction* of endothelial [vascular cell adhesion molecule-1] by . Positive_regulation VCAM1 TNF 11397697 823819 In this study , we investigated the role of GATA proteins in the *induction* of [VCAM-1] by in human endothelial cells . Positive_regulation VCAM1 TNF 11397697 823827 In contrast , overexpression of GATA-3 was able to suppress *induced* [VCAM-1] expression . Positive_regulation VCAM1 TNF 11397697 823828 Our results provide evidence of the importance of GATA proteins in the *induction* of [VCAM-1] by in vascular endothelial cells . Positive_regulation VCAM1 TNF 11397697 823829 The switch from GATA-3 to GATA-6 is taken to be an important transcriptional control event in *induction* of [VCAM-1] . Positive_regulation VCAM1 TNF 11403206 824950 ICAM-1 , [VCAM-1] , and E-selectin expression were all *stimulated* by both IL-1beta and in the 24 h assays . Positive_regulation VCAM1 TNF 11435740 832691 stimulation *resulted* in a 4-fold increase in ICAM-1 and [VCAM-1] expression . Positive_regulation VCAM1 TNF 11436044 832709 Aprotinin inhibited *stimulated* expression of intercellular adhesion molecule-1 ( P =.019 at 1600 kIU/mL ) and [vascular cell adhesion molecule-1] ( P =.003 at 1600 kIU/mL ) but not E-selectin . Positive_regulation VCAM1 TNF 11459775 838699 We therefore examined the effects of the PPARalpha activator fenofibrate and the GR activator dexamethasone on *stimulated* expression of IL-6 and [vascular cell adhesion molecule-1] in vascular endothelial cells . Positive_regulation VCAM1 TNF 11459775 838703 Both fenofibrate and dexamethasone reduced TNFalpha induced IL-6 production in human vascular endothelial cells , but only fenofibrate reduced *stimulated* [vascular cell adhesion molecule-1] expression in these cells . Positive_regulation VCAM1 TNF 11459775 838706 Transient transfection of bovine aortic endothelial cells with an IL-6 promoter construct or a vascular cell adhesion molecule-1 promoter construct revealed that fenofibrate inhibited *induced* IL-6 promoter as well as [vascular cell adhesion molecule-1] promoter activities , whereas dexamethasone inhibited only the former . Positive_regulation VCAM1 TNF 11494147 846186 Importantly , the proteasome inhibitor PS-341 abrogated *induced* NF-kappaB activation , induction of ICAM-1 or [VCAM-1] , and increased adhesion of MM cells to BMSCs . Positive_regulation VCAM1 TNF 11500182 846982 Cilostazol strongly inhibited *induced* expression of [VCAM-1] protein and its mRNA . Positive_regulation VCAM1 TNF 11500182 846983 In transient transfection studies , cilostazol inhibited induced transcriptional *activation* of [VCAM-1] promoter . Positive_regulation VCAM1 TNF 11500927 847138 When pretreated with SME ( 50 and 100 microg/ml ) , the *induced* expression of [vascular adhesion molecule-1 (VCAM-1)] was notably attenuated ( 77.2 +/- 3.2 % and 80.0 +/- 2.2 % , respectively ) ; Positive_regulation VCAM1 TNF 11590165 882900 Here , we hypothesize that such protection includes anti-inflammatory actions and investigate whether cell derived apoE can inhibit *mediated* up-regulation of [vascular cell adhesion molecule-1] ( VCAM-1 ) in human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation VCAM1 TNF 11597929 870319 A recently discovered benzo ( b ) pyran-4-one derivative , S17834 ( 10 to 50 micromol/L ) , reduced *stimulated* [vascular cell adhesion molecule-1 (VCAM)] mRNA accumulation and protein expression in human umbilical vein endothelial cells . Positive_regulation VCAM1 TNF 11678640 873680 *induced* the expression of [VCAM-1] on HUVEC and GEC , but not MvE , while IFN-gamma induced VCAM-1 expression only on HUVEC . Positive_regulation VCAM1 TNF 11710545 880129 Suplatast did not affect *induced* [VCAM-1] expression . Positive_regulation VCAM1 TNF 11786478 901314 2. Pretreatment of HAECs with magnolol ( 5 microM ) significantly suppressed the *induced* expression of [vascular cell adhesion molecule-1] ( VCAM-1 ) ( 64.8+/-1.9 % ) , but had no effect on the expression of intercellular cell adhesion molecule-1 and endothelial cell selectin . Positive_regulation VCAM1 TNF 11904449 923043 We evaluated whether testosterone inhibited *induced* [VCAM-1] expression via its conversion to estradiol by the enzyme aromatase in human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation VCAM1 TNF 11904449 923044 Testosterone also attenuated *induced* [VCAM-1] protein expression , and this attenuation was abolished in the presence of anastrozole . Positive_regulation VCAM1 TNF 11961404 932602 Both SIN-1 and NP inhibited the *induced* [VCAM-1] mRNA expression in a dose dependent manner ( 0.25-2 mM ) . Positive_regulation VCAM1 TNF 11961404 932610 Analogue of cGMP ( 8-bromo-cGMP ) had no significant effect on *induced* [VCAM-1] mRNA expression and guanylate cyclase inhibitor ( ODQ ) also had no significant influence on the inhibitory effect of SIN-1 . Positive_regulation VCAM1 TNF 12013189 941616 When second passage cells were used , the expression of the adhesion molecules ICAM-1 and [VCAM-1] was markedly *increased* on all surfaces but not with . Positive_regulation VCAM1 TNF 12014678 941706 E-selectin ( peak at 4 hours ) and [VCAM-1] ( peak at 24 hours ) expression were significantly *increased* by but unchanged by reduced oxygenation . Positive_regulation VCAM1 TNF 12020745 942683 Effects of testosterone and 17-beta-estradiol on *induced* E-selectin and [VCAM-1] expression in endothelial cells . Positive_regulation VCAM1 TNF 12020745 942685 This study investigated the effects of testosterone and 17-beta-estradiol on *induced* endothelial expression of E-selectin and [vascular cell adhesion molecule-1] ( VCAM-1 ) and the potential roles of hormone receptors involved in these actions . Positive_regulation VCAM1 TNF 12020745 942687 As shown by Western blot analysis , co-administration with testosterone or 17-beta-estradiol increased the expression of E-selectin and [VCAM-1] *induced* by at 6 h and 3 h , respectively . Positive_regulation VCAM1 TNF 12020745 942689 Flow cytometric analysis showed that preincubation with androgen receptor antagonist cyproterone and estrogen receptor antagonist tamoxifen completely abrogated the upregulating effects of testosterone and 17-beta-estradiol on *induced* E-selectin and [VCAM-1] expression , respectively . Positive_regulation VCAM1 TNF 12037401 949217 No changes in [VCAM-1] expression were *induced* by TNF-alpha , IL-4 or bFGF , whereas both and IL-4 increased eotaxin release ( p < 0.05 ) . Positive_regulation VCAM1 TNF 12087872 959465 It is concluded that both testosterone and 17 beta-estradiol increase *induced* expression of E-selectin and [VCAM-1] in endothelial cells and these facts might indicate a mechanism by which gonadal hormones can indirectly enhance immune responses . Positive_regulation VCAM1 TNF 12115600 964174 Indeed , addition of hyperosmotic , pathophysiologically relevant concentrations of NaCl effectively inhibited IL-1beta or *induction* of [VCAM-1] , but not E-selectin , at the level of mRNA and cell surface protein . Positive_regulation VCAM1 TNF 12124212 965695 Because IL-18 is a proinflammatory cytokine known to mediate the production of and IL-1beta and to *induce* the expression of intercellular adhesion molecule-1 ( ICAM-1 ) and vascular cell adhesion molecule-1 ( [VCAM-1] ) , we hypothesized that neutralization of IL-18 would attenuate lipopolysaccharide (LPS) induced cardiac dysfunction . Positive_regulation VCAM1 TNF 12174154 974501 The purpose of this case controlled study was to investigate whether plasma concentrations of TNF-receptors I and II and *induced* cell adhesion molecule 1 [VCAM-1] could serve as more sensitive markers of tumor necrosis factor-alpha release in preeclamptic women than a direct measurement of circulating tumor necrosis factor-alpha . Positive_regulation VCAM1 TNF 12176131 975398 Albumin selectively inhibits *induced* expression of [vascular cell adhesion molecule-1] in human aortic endothelial cells . Positive_regulation VCAM1 TNF 12176131 975399 The inhibitory effect of BSA on *induced* [VCAM-1] expression was not attenuated by inhibition of intracellular GSH synthesis . Positive_regulation VCAM1 TNF 12176131 975400 Our data show that physiological concentrations of albumin selectively inhibit *induced* upregulation of [VCAM-1] expression and monocyte adhesion , most likely by inhibiting NF-kappa B activation in a GSH independent manner . Positive_regulation VCAM1 TNF 12237332 989180 *induced* endothelial [VCAM-1] , ICAM-1 , and E-selectin surface expression was inhibited dose dependently . Positive_regulation VCAM1 TNF 12370194 1034767 In addition , expression of NQO1 or Nrf2 inhibited induced *activation* of [VCAM-1] ( vascular cell adhesion molecule-1 ) gene expression in EC . Positive_regulation VCAM1 TNF 12372676 996457 Although zofenoprilat significantly and dose dependently reduced the expression of [vascular cell adhesion molecule-1] ( VCAM-1 ) , intercellular cell adhesion molecule-1 ( ICAM-1 ) , and E-selectin *induced* by ox-LDL ( P < .01 ) and ( P < .01 ) on HUVECs , enalaprilat did not . Positive_regulation VCAM1 TNF 12387879 1000264 Testosterone inhibits *induced* [vascular cell adhesion molecule-1] expression in human aortic endothelial cells . Positive_regulation VCAM1 TNF 12387879 1000265 We investigated the effect of testosterone ( T ) on *induced* expression of [vascular cell adhesion molecule-1] ( VCAM-1 ) in human aortic endothelial cells . Positive_regulation VCAM1 TNF 12417274 1011637 Furthermore , of the three rHDL preparations ( 16 micromol/l apoA-I ) only that containing the polyunsaturated PLPC significantly reduced *induced* [VCAM-1] expression ( by 29.9+/-9.1 % ) . Positive_regulation VCAM1 TNF 12429809 1015057 [VCAM-1] expression on MLMC was shown to be *up-regulated* by . Positive_regulation VCAM1 TNF 12479867 1032666 Involvement of transcription factors in plasma HDL protection against *induced* [vascular cell adhesion molecule-1] expression . Positive_regulation VCAM1 TNF 12479867 1032667 In addition , immunocytochemical staining analysis confirmed that HDL inhibited *induced* [VCAM-1] expression via reduced nuclear translocation of NF-kappaB . Positive_regulation VCAM1 TNF 12488365 1033014 In HDMEC , alpha-MSH ( 10 ( -8 ) /10 ( -12 ) M ) profoundly reduced the mRNA and protein expression of E-selectin , [vascular CAM (VCAM)-1] , and intercellular CAM (ICAM)-1 *induced* by LPS or as determined by semiquantitative RT-PCR , ELISA , and fluorescence activated cell sorter analysis . Positive_regulation VCAM1 TNF 12547825 1071455 Genistein , an ERbeta agonist , at low concentrations ( 1 and 10 nm ) also suppressed *induced* [VCAM-1] mRNA expression . Positive_regulation VCAM1 TNF 12547825 1071456 Other estrogenic compounds such as ethinyl estradiol and estrone did not have any effect on *induced* [VCAM-1] expression at the concentrations tested . Positive_regulation VCAM1 TNF 12547825 1071457 We further show that , 1 ) 17-epiestriol induces the expression of endothelial nitric-oxide synthase mRNA and protein , 2 ) 17-epiestriol prevents TNFalpha induced migration of NFkappaB into the nucleus , 3 ) N ( G ) -nitro-l-arginine methyl ester , an inhibitor of NO synthesis , abolishes 17-epiestriol mediated inhibition of *induced* [VCAM-1] expression and migration of NFkappaB from the cytoplasm to the nucleus . Positive_regulation VCAM1 TNF 12547825 1071458 Our results indicate that 17-epiestriol is more potent than 17-beta E ( 2 ) in suppressing *induced* [VCAM-1] expression and that this action is modulated at least in part through NO . Positive_regulation VCAM1 TNF 12585120 895564 Hydrocortisone inhibited *stimulated* PMN-HSC adhesion , and expression of [VCAM-1] by suppressing the activity of NF-kappa B . Positive_regulation VCAM1 TNF 12587980 1029762 *induced* [VCAM-1] and ICAM-1 expression and Jurkat T cell binding . Positive_regulation VCAM1 TNF 12587980 1029764 Our results , therefore , indicate that p38 kinase mediates *induced* [VCAM-1] expression and cell adhesion , whereas JNK suppresses VCAM-1 expression that is independent to NFkappaB activation . Positive_regulation VCAM1 TNF 12601631 1062407 Beraprost significantly decreased *induced* [VCAM-1] expression in human vascular endothelial cells . Positive_regulation VCAM1 TNF 12606638 1079730 In the present study , we demonstrate that adenoviral mediated expression of dominant negative N17Rac1 ( Ad.N17Rac1 ) suppresses *induced* [vascular cell adhesion molecule-1] ( VCAM-1 ) , intercellular adhesion molecule-1 ( ICAM-1 ) , and E-selectin gene expression in a dose dependent manner . Positive_regulation VCAM1 TNF 12606638 1079741 In contrast , Ad.N17Rac1 inhibited TNF-alpha induced NF-kappaB-driven HIV ( kappaB ) ( 4 ) -CAT and p288VCAM-Luc promoter activity , suggesting that N17Rac1 inhibits *induced* [VCAM-1] , E-selectin , and ICAM-1 through suppressing NF-kappaB mediated transactivation . Positive_regulation VCAM1 TNF 12606638 1079754 In addition , expression of superoxide dismutase by adenovirus suppressed *induced* [VCAM-1] , E-selectin , and ICAM-1 mRNA accumulation . Positive_regulation VCAM1 TNF 12633744 1068266 Treatment of HAEC with DFO ( 0.01-0.1 mM ) or NC ( 0.1 and 0.5 mM ) time- and dose-dependently inhibited *induced* protein expression of E-selectin , [vascular cell adhesion molecule-1] ( VCAM-1 ) , and intercellular adhesion molecule-1 ( ICAM-1 ) . Positive_regulation VCAM1 TNF 12707043 1082779 Blocking studies revealed that T-cell arrest on MHECs was mediated by constitutive [VCAM-1] and *induced* RANTES . Positive_regulation VCAM1 TNF 12707049 1082780 The inhibitory effect of PPN on *induced* [VCAM-1] expression at 24 hours was evident when the NO donor was added for as short as 2 hours . Positive_regulation VCAM1 TNF 12713595 1083447 To investigate the role of iron in *induced* [VCAM-1] gene expression , human dermal microvascular endothelial cells ( HDMEC ) were stimulated with TNF alpha in the presence of iron chelators and examined for expression of VCAM-1 . Positive_regulation VCAM1 TNF 12713595 1083448 These data suggest that iron plays a critical role in *mediated* [VCAM-1] induction in HDMEC , and the target for iron effects may be IRF-1 , NF-kappa B , and potentially chromatin remodeling . Positive_regulation VCAM1 TNF 12714597 1100500 P2Y2 antisense oligonucleotides inhibited [VCAM-1] expression *induced* by UTP but not by . Positive_regulation VCAM1 TNF 12788693 1133977 2 ) 4-h *induced* expression of E-selectin , [VCAM-1] , and HL60 cell adhesion to HUVEC that have become desensitized to IL-1 beta activation ; Positive_regulation VCAM1 TNF 12890192 1117234 It also inhibited *induced* ICAM-1 and [VCAM-1] expression by HUVEC at 10-6 mol L-1 . Positive_regulation VCAM1 TNF 12890192 1117237 Low-dose MTX may act on psoriasis by suppressing the *induced* expression of ICAM-1 and [VCAM-1] by vascular endothelial cells . Positive_regulation VCAM1 TNF 12963644 1143456 After exposure to low shear stress , ( 50 ng/mL , 6 hours ) specifically *stimulated* [vascular cell adhesion molecule (VCAM)-1] expression in ECs but not VSMCs . Positive_regulation VCAM1 TNF 1374096 186279 *stimulates* expression of [vascular cell adhesion molecule-1] ( VCAM-1 ) in both of these neural cell lines . Positive_regulation VCAM1 TNF 1374588 186318 In contrast , dermal fibroblasts upregulated intercellular adhesion molecule-1 ( ICAM-1 ) but not [VCAM-1] expression in *response* to . Positive_regulation VCAM1 TNF 1378077 190573 However , although TNF-alpha induced cell surface and mRNA expression of VCAM-1 in HDMEC was transient , peaking after 16 h of stimulation , stimulation *led* to persistently elevated cell surface expression of [VCAM-1] on HUVEC . Positive_regulation VCAM1 TNF 1380176 193163 *induced* expression of endothelial adhesion molecules , ICAM-1 and [VCAM-1] , is linked to protein kinase C activation . Positive_regulation VCAM1 TNF 14509560 1146400 HBECs , freshly isolated from resected bronchi at the time of surgery in ex-smokers with lung cancer , constitutively expressed over 3 times more ICAM-1 than VCAM-1 ( P < 0.05 ) and secreted greater amounts of IL-8 than of GM-CSF or RANTES ( P < 0.001 ) . Stimulation of HBECs with IL-4 , TNF-alpha or IL-4 plus TNF-alpha upregulated ICAM-1 expression ( P < 0.05 ) and increased GM-CSF and IL-8 secretion ( P < 0.05 ) . Similarly , [VCAM-1] expression was significantly *increased* by IL-4 plus , while RANTES release was significantly enhanced by IL-4 or by IL-4 plus TNF-alpha ( P < 0.05 ) , but not by TNF-alpha alone ( P > 0.05 ) . Positive_regulation VCAM1 TNF 14565715 1154953 HPVEC express E-selectin , ICAM-1 , and [VCAM-1] in *response* to the inflammatory cytokine similarly to other types of cultured human endothelial cells . Positive_regulation VCAM1 TNF 14583404 1158917 In *response* to , isolated mouse brain endothelial cells ( MBEC ) express [vascular cell adhesion molecule-1] ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ) . Positive_regulation VCAM1 TNF 14592496 1159952 11,12-epoxyeicosatrienoic acid ( 11,12-EET ) : structural determinants for inhibition of *induced* [VCAM-1] expression . Positive_regulation VCAM1 TNF 14597987 1161039 AS-IV also inhibits *induced* [VCAM-1] expression . Positive_regulation VCAM1 TNF 14615388 1188002 Shear stress increases ICAM-1 and decreases [VCAM-1] and E-selectin expressions *induced* by [ alpha ] in endothelial cells . Positive_regulation VCAM1 TNF 14615388 1188004 Shear stress increased the TNF-alpha induced expression of intercellular adhesion molecule-1 ( ICAM-1 ) at both mRNA and surface protein levels , but decreased the *induced* expression of [vascular adhesion molecule-1 (VCAM-1)] and E-selectin . Positive_regulation VCAM1 TNF 14615388 1188007 The recovery of the *induced* [VCAM-1] and E-selectin mRNA expressions following preshearing , however , required a static incubation time of > 6 hours ( complete recovery at 24 hours ) . Positive_regulation VCAM1 TNF 14615388 1188009 Our findings suggest that shear stress plays differential roles in modulating the *induced* expressions of ICAM-1 versus [VCAM-1] and E-selectin genes in ECs . Positive_regulation VCAM1 TNF 14720501 1197832 Finally , *induced* activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) activation and resultant intracellular adhesion molecule-1 ( ICAM-1 ) and [vascular cell adhesion molecule-1] ( VCAM-1 ) expressions were inhibited by ebselen . Positive_regulation VCAM1 TNF 14720501 1197836 Specific inhibitors for JNK and NF-kappaB also inhibited *induced* ICAM-1 and [VCAM-1] expressions in HUVEC . Positive_regulation VCAM1 TNF 14741380 1203261 RORalpha1 and RORalpha4 suppress *induced* [VCAM-1] and ICAM-1 expression in human endothelial cells . Positive_regulation VCAM1 TNF 14741380 1203263 Adenovirus mediated overexpression of RORalpha1 and RORalpha4 suppressed *induced* expression of [vascular cell adhesion molecule-1] ( VCAM-1 ) and intracellular adhesion molecule-1 ( ICAM-1 ) in human umbilical vein endothelial cells . Positive_regulation VCAM1 TNF 14764813 1207443 Furthermore , we studied the direct effect of GH and IGF-I and serum from GH-treated subjects on basal and *stimulated* expression of [VCAM-1] and E-selectin on cultured human umbilical vein endothelial cells . Positive_regulation VCAM1 TNF 14978108 1213430 The increase in intrahepatic NK cells depended on KCs and the *dependent* up-regulation of the adhesion molecule [VCAM-1] in the liver , but not on NKT cells . Positive_regulation VCAM1 TNF 14984317 1214672 The effect of high glucose concentration on *induced* expression of ELAM-1 , [VCAM-1] and ICAM-1 was negligible , if at all . Positive_regulation VCAM1 TNF 14991079 1182875 Here we show that BMS-345541 , a highly selective inhibitor of IkappaB kinase , inhibited the *induced* expression of both ICAM-1 and [VCAM-1] in human umbilical vein endothelial cells at the same concentration range as cytokine expression is inhibited in monocytic cells ( IC ( 50 ) congruent with 5 microM ) . Positive_regulation VCAM1 TNF 15006393 1217564 Discovery of novel heteroaryl substituted chalcones as inhibitors of *induced* [VCAM-1] expression . Positive_regulation VCAM1 TNF 15006393 1217565 Novel chalcone derivatives have been discovered as potent inhibitors of *induced* [VCAM-1] expression . Positive_regulation VCAM1 TNF 15016640 1243405 Early cell cycle arrest of aortic smooth muscle cells was found to inhibit the *induced* upregulation of [vascular cell adhesion molecule-1] and intercellular adhesion molecule-1 , important markers of vascular cell activation in diseases such as atherosclerosis . Positive_regulation VCAM1 TNF 15068815 1232313 Pretreatment of HUVEC with butyrate inhibited *induced* expression of [vascular cell adhesion molecule-1] ( VCAM-1 ) and intracellular cell adhesion molecule-1 ( ICAM-1 ) in a time and concentration dependent manner . Positive_regulation VCAM1 TNF 15113938 1241389 significantly *induced* HUVEC protein expression of [VCAM-1] , ICAM-1 , and E-selectin with increasing mRNA levels . Positive_regulation VCAM1 TNF 15113938 1241391 Luteolin and apigenin inhibited the *induced* upregulation of THP-1 adhesion and [VCAM-1] expression ; Positive_regulation VCAM1 TNF 15127201 1252061 Activation of the receptor for advanced glycation end products ( RAGE ) reportedly triggers cellular responses implicated in the pathogenesis of diabetes , such as increasing [vascular cell adhesion molecule-1] ( VCAM-1 ) expression on vascular endothelial cells and *inducing* secretion by mononuclear cells . Positive_regulation VCAM1 TNF 15145610 1247724 We show that signaling is *required* for [VCAM-1] expression by astrocytes , not the vascular endothelium . Positive_regulation VCAM1 TNF 15166790 1253332 LDL ( - ) induces the production of chemokines , such as IL-8 and monocyte chemotactic protein 1 , and increases *induced* production of [vascular cell adhesion molecule 1] , with these molecules being involved in early phases of leukocyte recruitment . Positive_regulation VCAM1 TNF 15191888 1295217 We further investigated the role of SphK1 in *induced* expression of inflammatory genes , such as monocyte chemoattractant protein-1 ( MCP-1 ) and [VCAM-1] by using small interfering RNA ( siRNA ) specifically for SphK1 . Positive_regulation VCAM1 TNF 15191888 1295247 SphK1 siRNA also inhibited *induced* cell surface expression of [VCAM-1] , but not ICAM-1 , protein . Positive_regulation VCAM1 TNF 15265939 1275741 Phenyl methimazole inhibits *induced* [VCAM-1] expression in an IFN regulatory factor-1 dependent manner and reduces monocytic cell adhesion to endothelial cells . Positive_regulation VCAM1 TNF 15265939 1275745 Combined , the results indicate that phenyl methimazole can reduce *induced* [VCAM-1] expression in an IFN regulatory factor-1 dependent manner and that this contributes significantly to reduced monocytic cell adhesion to TNF-alpha activated HAEC . Positive_regulation VCAM1 TNF 15374848 1323858 Carvedilol inhibited *stimulated* endothelial [vascular cell adhesion molecule-1] ( VCAM-1 ) and E-selectin ( 66.0+/-2.0 % and 55.60+/-1.0 % of control , P < 0.05 , respectively ) expression , whereas probucol inhibited only VCAM-1 expression ( 79.0+/-5.0 % of control , P < 0.05 ) . Positive_regulation VCAM1 TNF 15489375 1359454 In the present study , we show that pretreatment with rottlerin , a specific inhibitor of protein kinase C (PKC)-delta , or transient transfection with antisense PKCdelta oligonucleotides significantly inhibits *induced* expression of [VCAM-1] , but not of intercellular adhesion molecule (ICAM)-1 in human lung epithelium A549 cells . Positive_regulation VCAM1 TNF 15509547 1328038 The elevated serum levels present in aged mice may *contribute* to increased RANTES and [VCAM-1] expression in mesangial cells . Positive_regulation VCAM1 TNF 15509547 1328039 Furthermore , cells from 28-month-old mice were more sensitive to *induced* RANTES and [VCAM-1] up-regulation . Positive_regulation VCAM1 TNF 15553662 1338685 In this study , we investigated whether nifedipine could inhibit *induced* [vascular cell adhesion molecule-1] ( VCAM-1 ) expression and subsequent leukocyte adhesion to human umbilical vein endothelial cells ( HUVEC ) . Positive_regulation VCAM1 TNF 15553662 1338686 Nifedipine significantly inhibited *induced* up-regulation of [VCAM-1] mRNA levels in HUVEC . Positive_regulation VCAM1 TNF 15570244 1344192 Shear stress varied from 1.0 dyne/cm 2 ( microvascular venular flow ) , in which [VCAM-1] ligand interactions *induced* by primarily controlled adherence , to 0.1 dyne/cm 2 ( low flow ) , in which stimulation had little effect on adherence . Positive_regulation VCAM1 TNF 15576639 1361315 SOD expression significantly suppressed *induced* expression of [vascular cell adhesion molecule-1] and intercellular cell adhesion molecule-1 and reduced the binding of the human neutrophils to TNF-alpha stimulated HAECs . Positive_regulation VCAM1 TNF 15625106 1362074 As in skin , *induces* E-selectin and [vascular cell adhesion molecule 1] only on venular ECs , whereas intercellular adhesion molecule-1 is up-regulated on all human ECs . Positive_regulation VCAM1 TNF 15626898 1349303 *induced* ICAM-1 and [VCAM-1] expression in primary cultures of human umbilical vein endothelial cells was reduced by co-incubation with CsA . Positive_regulation VCAM1 TNF 15662020 1382005 We demonstrate that 15d-PGJ2 induced RORalpha1 and RORalpha4 expression and inhibited *induced* [vascular cell adhesion molecule-1] ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ) expression in human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation VCAM1 TNF 15662020 1382007 Adenovirus mediated overexpression of RORalpha1 inhibited *induced* [VCAM-1] and ICAM-1 expression , and overexpression of a mutant form of RORalpha1 ( RORalpha1Delta ) , which inhibited transcriptional activity of RORalpha1 and RORalpha4 , attenuated its inhibition . Positive_regulation VCAM1 TNF 15662020 1382009 Furthermore , we found that RORalpha1Delta attenuated the inhibitory actions of 15d-PGJ2 on *induced* [VCAM-1] and ICAM-1 expression . Positive_regulation VCAM1 TNF 15665118 1395335 Binding of monocytes to *activated* human endothelial cells as well as to [VCAM-1] or ICAM-1 also resulted in an increase of MT1-MMP expression . Positive_regulation VCAM1 TNF 15671209 1366093 Phloretin prevented *stimulated* upregulation of [VCAM-1] , ICAM-1 , and E-selectin expression in a concentration dependent manner . Positive_regulation VCAM1 TNF 15696199 1382734 In aortae from TXNIP-deficient mice , *induced* [VCAM1] expression was inhibited . Positive_regulation VCAM1 TNF 15720567 1376528 Although and IL-1beta , at concentrations a little higher than those in sera of periodontitis patients , *up-regulated* the expression of intercellular adhesion molecule-1 and [vascular cell adhesion molecule-1] , P. gingivalis antigens had only a slight stimulatory effect . Positive_regulation VCAM1 TNF 15742809 1378891 Also , 1 and 2 inhibited induced *up-regulation* of ICAM-1 , [VCAM-1] and E-selectin . Positive_regulation VCAM1 TNF 15797891 1403771 In cultured tubular epithelial cells , rosiglitazone significantly decreased the expression of ICAM-1 and [VCAM-1] *induced* by or IL-1beta , inhibited the degradation of inhibitor kappaBalpha ( IkappaBalpha ) and blocked the activation of the p65 subunit of nuclear factor (NF)-kappaB . Positive_regulation VCAM1 TNF 15812241 1392230 Realtime PCR studies showed that while potently *induced* [VCAM-1] gene expression , BE completely prevented it . Positive_regulation VCAM1 TNF 15843005 1398304 Fresh and cryopreserved/thawed cells showed comparable anti-inflammatory and anti-coagulant activity , as judged by the basal and *induced* [VCAM-1] , ICAM-1 , E-selectin , and thrombomodulin expression . Positive_regulation VCAM1 TNF 15880045 1406195 stimulation of PAEC-Gal-/- and PAEC-Gal+/+ *induced* an increase of CD62E and [CD106] expression and increased cellular adhesion , in particular , of PMN . Positive_regulation VCAM1 TNF 15897777 1408646 The inhibitory effect of ESM on *induced* [VCAM-1] expression was attenuated by inhibition of intracellular glutathione ( GSH ) synthesis . Positive_regulation VCAM1 TNF 15940366 1415554 *stimulated* [VCAM1] expression , consistent with a synovial fibroblast phenotype . Positive_regulation VCAM1 TNF 15975820 1434695 IL-17 reduces *induced* Rantes and [VCAM-1] expression . Positive_regulation VCAM1 TNF 15975820 1434700 IL-17 also inhibited the *mediated* expression of adhesion molecule [VCAM-1] , and the NF-kappaB binding to the VCAM-1 promoter-specific site , along with the inhibitor of NF-kappaB , IkappaB-beta . Positive_regulation VCAM1 TNF 16002747 1441313 In contrast to LPS treatment , L-4F did not inhibit IL-1beta- or *induced* [vascular cell adhesion molecule-1] expression . Positive_regulation VCAM1 TNF 16115476 1448889 A novel thiazolidinedione MCC-555 down-regulates *induced* expression of [vascular cell adhesion molecule-1] in vascular endothelial cells . Positive_regulation VCAM1 TNF 16115476 1448891 Transient transfection of bovine aortic ECs with a VCAM-1 promoter construct revealed that MCC-555 inhibited *induced* [VCAM-1] promoter activity . Positive_regulation VCAM1 TNF 16115476 1448893 The considered PPARdelta activator GW501516 and the considered PPARalpha activator fenofibrate also inhibited *induced* [VCAM-1] expression , whereas pioglitazone and rosiglitazone did not . Positive_regulation VCAM1 TNF 16129813 1450021 GSK-3 inhibition also significantly suppressed the *induced* increase in TF activity and [VCAM-1] cell-surface expression . Positive_regulation VCAM1 TNF 16129813 1450025 GSK-3 regulates *induced* IkappaB-alpha degradation and NF-kappaB activation independent of IkappaB-kinase-beta and subsequent induction of TF and [VCAM-1] expression in human endothelial cells . Positive_regulation VCAM1 TNF 16249517 1471757 Stimulation of hRVECs with VEGF ( 165 ) , , or IL-1beta for 6 to 24 hours *caused* significant induction of intracellular adhesion molecule (ICAM)-1 and [vascular cell adhesion molecule (VCAM)-1] expression . Positive_regulation VCAM1 TNF 16271621 1479238 Arsenite enhances *induced* expression of [vascular cell adhesion molecule-1] . Positive_regulation VCAM1 TNF 16271621 1479239 Our study demonstrated that arsenite pretreatment potentiated the *induced* [VCAM-1] expression with up-regulations of both activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) . Positive_regulation VCAM1 TNF 16271621 1479240 Our investigation revealed that , by depleting GSH , arsenite attenuated the *induced* [VCAM-1] expression as well as a potentiation of AP-1 and an attenuation of NF-kappaB activations by TNF-alpha . Positive_regulation VCAM1 TNF 16271621 1479241 Moreover , we found that depletion of GSH would also attenuate the *induced* [VCAM-1] expression with a down-regulation of the TNF-alpha induced NF-kappaB activation and without significant effect on AP-1 . Positive_regulation VCAM1 TNF 16271621 1479246 On the other hand , the *induced* [VCAM-1] expression could be completely abolished by inhibition of AP-1 or NF-kappaB activity , suggesting that activation of both AP-1 and NF-kappaB was necessary for VCAM-1 expression . Positive_regulation VCAM1 TNF 16271621 1479252 In summary , we demonstrate that arsenite enhances the *induced* [VCAM-1] expression in HUVECs via regulation of AP-1 and NF-kappaB activities in a GSH-sensitive manner . Positive_regulation VCAM1 TNF 16288471 1509661 Here , the roles of mitogen activated protein kinases ( MAPKs ) and NF-kappaB in *induced* expression of [vascular cell adhesion molecule (VCAM)-1] were investigated in human tracheal smooth muscle cells ( HTSMCs ) . Positive_regulation VCAM1 TNF 16288471 1509668 Transfection with dominant negative mutants of MEK1/2 , ERK1 , ERK2 , p38 , and JNK attenuated *induced* [VCAM-1] expression . Positive_regulation VCAM1 TNF 16288471 1509669 Furthermore , *induced* [VCAM-1] expression was significantly blocked by a selective NF-kappaB inhibitor helenalin . Positive_regulation VCAM1 TNF 16288471 1509675 [VCAM-1] promoter activity was *enhanced* by in HTSMCs transfected with VCAM-1-Luc , which was inhibited by helenalin , U0126 , SB202190 , and SP600125 . Positive_regulation VCAM1 TNF 16288471 1509676 These results suggest that in HTSMCs , activation of MAPK pathways , NF-kappaB , and p300 is essential for *induced* [VCAM-1] expression . Positive_regulation VCAM1 TNF 16309209 1486599 These findings support the hypothesis that expression of E-selectin and [VCAM-1] may be *initiated* by the release of at an early stage of tumour development . Positive_regulation VCAM1 TNF 16313198 1486902 Using primary human umbilical vein endothelial cells , we evaluated the activities of compound 1 on *induced* expression of cell adhesion molecules , viz. , ICAM-1 , [VCAM-1] , and E-selectin , which play key roles in controlling various inflammatory diseases . Positive_regulation VCAM1 TNF 16317058 1518953 Lipopolysaccharide and *induced* [VCAM-1] and ICAM-1 mRNA and protein expression , as detected by real-time quantitative PCR , fluorescence activated cell sorting , and confocal microscopy , but this effect was inhibited when cells were incubated with DHT . Positive_regulation VCAM1 TNF 16325162 1511627 APE1/ref-1 overexpression also suppressed expression of [VCAM-1] *induced* by . Positive_regulation VCAM1 TNF 16353157 1526373 We show that phenoxodiol inhibits hallmarks of endothelial cell activation , namely or IL-1 *induced* E-selectin and [VCAM-1] expression and IL-8 secretion . Positive_regulation VCAM1 TNF 16413026 1618808 In addition to fractalkine , ALA successfully inhibited *stimulated* expression of [vascular cell adhesion molecule-1] and monocyte chemotactic protein-1 in cultured VSMCs . Positive_regulation VCAM1 TNF 16439686 1527861 In considering endothelial mechanisms responsible for this effect , we found that endothelial lipase (EL) overexpression in both EC and non-EL expressing NIH/3T3 mouse embryonic fibroblasts cells significantly decreased *induced* [VCAM1] expression and promoter activity in a manner dependent on HDL concentration and intact EL activity . Positive_regulation VCAM1 TNF 16456024 1522389 In vitro infliximab prevented *induced* CD40 and [VCAM-1] expression by HIMEC , and reduced PBT , but not platelet , surface CD40L expression and sCD40L release . Positive_regulation VCAM1 TNF 16457818 1522442 Western blot analysis and luciferase activity assay showed that anthocyanins inhibited *induced* [vascular cell adhesion molecule-1] , intracellular adhesion molecule-1 , and cyclooxygenase-2 levels , which is through NF-kappaB dependent pathway . Positive_regulation VCAM1 TNF 16462909 1495658 In addition , mediated [VCAM-1] *activation* was substantially impeded by CHD treatment . Positive_regulation VCAM1 TNF 16529752 1671845 We conclude that cerivastatin and simvastatin reduce induced *up-regulation* of ICAM-1 and [VCAM-1] surface expression via increased protein shedding mediated by HMG-CoA reductase inhibition and subsequent isoprenoid depletion . Positive_regulation VCAM1 TNF 16545799 1541993 Unlike PTX and M1 , M4 and M5 poorly inhibited lipopolysaccaride stimulated tumor necrosis factor-alpha (TNF-alpha) release by RAW 264.7 murine macrophages , and did not affect at all cell proliferation and upregulation of *induced* [vascular cell adhesion molecule-1] ( VCAM-1 ) in H5V endothelioma cells . Positive_regulation VCAM1 TNF 16549374 1549772 The noteworthy increase in protein levels of intercellular adhesion molecule-1 ( ICAM-1 ) and [vascular cell adhesion molecule-1] ( VCAM-1 ) *induced* by was significantly decreased after incubation of the cells with 1,25 ( OH ) ( 2 ) D ( 3 ) , this effect not being seen on E-selectin expression . Positive_regulation VCAM1 TNF 16641609 1553063 Surface expression of ICAM-1 , [VCAM-1] , and E-/P-selectin on MVEC was *up-regulated* by but unaffected by hypoxia/reoxygenation in the absence of TNF-alpha . Positive_regulation VCAM1 TNF 16644735 1583261 The adaptor molecule Lnk negatively regulates *dependent* [VCAM-1] expression in endothelial cells through inhibition of the ERK1 and -2 pathways . Positive_regulation VCAM1 TNF 16644735 1583263 In this study , we have shown that , in ECs , Lnk down-regulates the expression , at both mRNA and protein levels , of the proinflammatory molecules [VCAM-1] and E-selectin *induced* by . Positive_regulation VCAM1 TNF 16647464 1553185 stimulation and TCR/CD28 co-stimulation significantly *increased* EC [ICAM-1/VCAM-1-expression] and LC CD25 surface expression , respectively . Positive_regulation VCAM1 TNF 16715652 1565074 CAMP-response element binding protein mediates *induced* [vascular cell adhesion molecule-1] expression in endothelial cells . Positive_regulation VCAM1 TNF 16715652 1565075 *induces* endothelial dysfunction and [VCAM-1] expression in endothelial cells ( ECs ) . Positive_regulation VCAM1 TNF 16715652 1565076 We examined whether the cAMP-response element binding protein ( CREB ) , a transcription factor that mediates cytokine expression and vascular remodeling , is involved in *induced* [VCAM-1] expression . Positive_regulation VCAM1 TNF 16715652 1565139 Adenovirus mediated overexpression of a dominant negative form of CREB suppressed *induced* [VCAM-1] and c-fos expression . Positive_regulation VCAM1 TNF 16715652 1565143 Our results suggest that the p38-MAPK/CREB pathway plays a critical role in *induced* [VCAM-1] expression in vascular endothelial cells . Positive_regulation VCAM1 TNF 16734619 1566220 and interferon (IFN)-gamma *enhanced* both ICAM-1 and [VCAM-1] expression on HGF . Positive_regulation VCAM1 TNF 16734619 1566229 However , TGF-beta1 inhibited the [VCAM-1] expression *induced* by or IL-4 . Positive_regulation VCAM1 TNF 16872805 1672420 We therefore examined the effect of blocking the NFkappaB pathway on *stimulated* ICAM-1 and [VCAM-1] expression in primary cultures of human aortic smooth muscle cells using an adenoviral wild-type IkappaB alpha construct ( Ad.IkappaB alpha ) and dominant negative IKKalpha ( Ad.IKKalpha+/- ) and IKKbeta ( Ad.IKKbeta+/- ) constructs . Positive_regulation VCAM1 TNF 16872805 1672422 Ad . IkappaB alpha treatment was found to block NFkappaB DNA binding , and thereby completely prevent *stimulated* ICAM-1 and [VCAM-1] expression without influencing IKK activity . Positive_regulation VCAM1 TNF 16872805 1672439 Ad.IKKbeta+/- treatment completely inhibited TNFalpha stimulated IKK kinase activity , IkappaB alpha degradation and NFkappaB DNA binding in addition to completely blocking *stimulated* ICAM-1 and [VCAM-1] expression . Positive_regulation VCAM1 TNF 16872805 1672447 Our results demonstrate that *stimulated* ICAM-1 and [VCAM-1] expression in human aortic smooth muscle cells is NFkappaB dependent , that IKKbeta is a suitable target for drug therapy and Ad.IKKbeta+/- an effective inhibitor of TNFalpha stimulated ICAM-1 and VCAM-1 expression . Positive_regulation VCAM1 TNF 16873730 1613649 In lesions , pro-inflammatory MCP-1 and expression *increased* 2- and 3.5-fold , respectively , [vascular cell adhesion molecule (VCAM)-1] expression enhanced and interleukin (IL)-1 receptor antagonist reduced by 50 % . Positive_regulation VCAM1 TNF 16887803 1646150 Moreover , nitroalkenes inhibited endothelial *induced* [vascular cell adhesion molecule 1] expression and monocyte rolling and adhesion . Positive_regulation VCAM1 TNF 16888237 1613913 Furthermore , gene silencing of RAGE by RNA interference decreased the expression of *induced* [VCAM-1] in both mRNA and protein levels . Positive_regulation VCAM1 TNF 16888237 1613914 RAGE contributes at least partially to the *induced* [VCAM-1] expression in both mRNA and protein levels . Positive_regulation VCAM1 TNF 16895689 1496949 However , Lnk overexpression significantly reduced *mediated* expression of [VCAM-1] ( at mRNA and protein levels ) in activated EC as compared with controls . Positive_regulation VCAM1 TNF 16919261 1608610 These results suggest that azelnidipine works as an anti-atherogenic agent by inhibiting the reactive oxygen species dependent expression of [VCAM-1] *induced* by 7-ketocholesterol and . Positive_regulation VCAM1 TNF 16920299 1666192 Evidence presented in this report demonstrated that CML-1 inhibited the adhesive capacity of HUVEC and the mediated *induction* of E-selectin , ICAM-1 and [VCAM-1] in HUVEC by inhibiting the IkB/NF-kB signaling pathway at the level of IkB kinase , which may explain the ability of CML-1 to suppress inflammation and modulate the immune response . Positive_regulation VCAM1 TNF 16934424 1724324 *upregulates* [VCAM-1] and NF-kappaB in fibroblasts from nasal polyps . Positive_regulation VCAM1 TNF 16934424 1724327 Lung and synovial fibroblasts produce [VCAM-1] in *response* to . Positive_regulation VCAM1 TNF 1697486 139539 As determined by enzyme linked immunosorbent assay and radioimmunoprecipitation of metabolically labeled cells , [VCAM-1] was minimally expressed on unstimulated human umbilical vein endothelium ( HUVE ) , but was rapidly *induced* by recombinant human ( rhTNF-alpha ) , rh interleukin-1 , and lipopolysaccharide . Positive_regulation VCAM1 TNF 17008592 1641157 *mediated* induction of [vascular cell adhesion molecule-1] ( VCAM-1 ) was attenuated by all of these inhibitors , whereas in contrast , stimulation of intercellular adhesion molecule-1 ( ICAM-1 ) was blocked by MG-132 alone . Positive_regulation VCAM1 TNF 17052676 1636329 However , the expression of [VCAM-1] on BEAS-2B cells was only *up-regulated* by induced NF-kappaB activity . Positive_regulation VCAM1 TNF 17063735 1637325 Compared with unstimulated cultures , histamine or IL-4 + , at the highest concentrations tested , significantly *increase* [VCAM-1] expression ( p < 0.05 ) . Positive_regulation VCAM1 TNF 17063735 1637327 No effect of the drug on IL-4 + *induced* [VCAM-1] expression was observed . Positive_regulation VCAM1 TNF 17068152 1693044 We observed that p75 was essential for *induced* E-selectin , [vascular cell adhesion molecule 1] ( VCAM-1 ) , and intercellular adhesion molecule 1 ( ICAM-1 ) expression . Positive_regulation VCAM1 TNF 17071855 1637711 ( stimulation also *upregulates* [vascular cell adhesion molecule-1] expression on the hNSCs themselves and increases NSC-endothelial interactions . ) Positive_regulation VCAM1 TNF 17085432 1675741 Role for neutral sphingomyelinase-2 in alpha *stimulated* expression of [vascular cell adhesion molecule-1 (VCAM)] and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells : p38 MAPK is an upstream regulator of nSMase2 . Positive_regulation VCAM1 TNF 17184171 1724544 Effects of PGC-1alpha on *induced* MCP-1 and [VCAM-1] expression and NF-kappaB activation in human aortic smooth muscle and endothelial cells . Positive_regulation VCAM1 TNF 17184171 1724567 Consequently , NF-kappaB activity and MCP-1 and [VCAM-1] *induced* by are suppressed . Positive_regulation VCAM1 TNF 17209004 1732460 In marked contrast to HSVEC , venous and coronary artery flow attenuated *induced* E-selectin and [VCAM-1] expression on HCAEC , whereas coronary artery flow further induced ICAM-1 on cytokine stimulated HCAEC . Positive_regulation VCAM1 TNF 17209004 1732464 Interestingly , Kruppel-like factor (KLF) 4 overexpression in HCAEC and HSVEC significantly reduced *induced* E-selectin and [VCAM-1] expression in static conditions , while ICAM-1 expression remained constant . Positive_regulation VCAM1 TNF 17253641 1696546 Also , estrogen treatment inhibited [VCAM-1] expression *induced* by in cerebral vascular endothelial ( CVE ) cells via inhibition of nuclear factor-kappaB (NFkappaB) , which is produced in various glial cells upon TMEV infection . Positive_regulation VCAM1 TNF 17259331 1691246 Isoliquiritigenin abolished *induced* mRNA accumulation of [VCAM-1] and E-selectin . Positive_regulation VCAM1 TNF 17292586 1725832 TNFR1 induced NF-kappaB , but not ERK , p38MAPK or JNK activation , mediates *induced* ICAM-1 and [VCAM-1] expression on endothelial cells . Positive_regulation VCAM1 TNF 17321745 1711803 We have found that compound 8a also significantly inhibited the *induced* expression of [VCAM-1] and E-selectin , which play key roles in various inflammatory diseases . Positive_regulation VCAM1 TNF 17327359 1740873 JWH133 also attenuates the *induced* ICAM-1 and [VCAM-1] expression in human liver sinusoidal endothelial cells ( HLSECs ) and the adhesion of human neutrophils to HLSECs in vitro . Positive_regulation VCAM1 TNF 17371935 1748315 Western blot and immunohistochemical analysis showed that *leads* to [VCAM-1] and ICAM-1 expressions that were inhibited by antiserum to human TNF receptor or by AP-1 inhibitor nobiletin . Positive_regulation VCAM1 TNF 17434475 1742627 The result of the enzyme immunoassay demonstrated that Gypenoside XLIX inhibited *induced* increase in cell surface [VCAM-1] protein levels in HUVECs . Positive_regulation VCAM1 TNF 17434980 1772094 Additionally , we have explored the effects of anandamide on *induced* ICAM-1 and [VCAM-1] expression and monocyte-endothelial adhesion in human coronary artery endothelial cells ( HCAECs ) . Positive_regulation VCAM1 TNF 17434980 1772096 Anandamide dose dependently attenuated the *induced* ICAM-1 and [VCAM-1] expression , NF-kappaB activation in HCAECs , and the adhesion of monocytes to HCAECs in a CB(1)- and CB(2) dependent manner . Positive_regulation VCAM1 TNF 17652447 1822206 In addition , we have assessed the role of the CB(2) receptor in *induced* ICAM-1 and [VCAM-1] expression in human liver sinusoidal endothelial cells ( HLSECs ) and in the adhesion of human neutrophils to HLSECs in vitro . Positive_regulation VCAM1 TNF 17652447 1822213 HU-308 also attenuated the *induced* ICAM-1 and [VCAM-1] expression in HLSECs , which expressed CB(2) receptors , and the adhesion of human neutrophils to HLSECs in vitro . Positive_regulation VCAM1 TNF 17692965 1937801 DS and SQ significantly attenuated *induced* expression of adhesion molecule [VCAM-1] and also ICAM-1 by DS in the cells . Positive_regulation VCAM1 TNF 17706953 1816846 OPG but not OPN stimulated a dose dependent increase in the expression of intercellular adhesion molecule-1 , [vascular cell adhesion molecule-1] and E-selectin by endothelial cells in the *presence* of ( p < or=0.05 ) which was reflected by enhanced binding of THP-1 monocytes . Positive_regulation VCAM1 TNF 17822279 1497194 It also inhibited *induced* expression of intercellular adhesion molecule-1 ( ICAM-1 ) , [vascular cell adhesion molecule-1] ( VCAM-1 ) , and E-selectin . Positive_regulation VCAM1 TNF 17869461 1810716 Our preliminary data indicates that SN has an inhibitory effect in vitro on *induced* [VCAM-1] expression at both mRNA level and protein level in HUVECs , and suggests that SN may be a novel method of immunotherapy for rheumatic carditis or rheumatic heart disease . Positive_regulation VCAM1 TNF 17916277 1874110 Walnut extract and ellagic acid decreased significantly the *induced* endothelial expression of both [VCAM-1] and ICAM-1 ( P < 0.01 ; Positive_regulation VCAM1 TNF 17929893 1819637 Compounds 1 and 2 inhibited *induced* up-regulation of [vascular cell adhesion molecule-1] ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ) , which also prevented adhesion of monocytes to HUVECs , and slightly suppressed the mRNA expression of the inflammation associated gene interleukin-1beta (IL-1beta) . Positive_regulation VCAM1 TNF 17950296 1882594 Telmisartan and PDTC reduced *stimulated* [VCAM-1] in a concentration dependent manner while losartan , EXP-3174 , EXP-3179 and dexamethasone were ineffective . Positive_regulation VCAM1 TNF 17956026 1814774 *enhanced* the secretion of [VCAM-1] and RANTES by fibroblasts derived from both NEnp and Enp , but did not affect the release of eotaxin . Positive_regulation VCAM1 TNF 17967773 1820397 When incubated with endothelial cells , HDL isolated from apoA-I ( M ) carriers was more effective than HDL from control and low-HDL subjects in stimulating endothelial nitric oxide synthase expression and activation and in downregulating *induced* expression of [vascular cell adhesion molecule-1] . Positive_regulation VCAM1 TNF 18025230 1827736 Basal and *induced* expression of [VCAM-1] , ICAM-1 , and E-selectin were increased in Hmox1 ( -/- ) vs Hmox1 ( +/+ ) EC , an effect reversed by Fe chelation using deferoxamine mesylate ( DFO ) . Positive_regulation VCAM1 TNF 18048767 1852481 In human umbilical vein endothelial cells ( HUVECs ) , the synthetic PPAR-delta ligands GW0742 and GW501516 significantly inhibited *induced* expression of [vascular cell adhesion molecule-1] and E-selectin ( assayed by real-time RT-PCR and Northern blotting ) , as well as the ensuing endothelial-leukocyte adhesion . Positive_regulation VCAM1 TNF 18084847 1834623 We have previously shown that nifedipine , one of the most popular DHPs , blocks *induced* monocyte chemoattractant protein-1 as well as [vascular cell adhesion molecule-1] ( VCAM-1 ) expression in endothelial cells by suppressing reactive oxygen species generation ( ROS ) . Positive_regulation VCAM1 TNF 18202320 1883810 FIR radiation also inhibited *mediated* expression of E-selectin , [vascular cell adhesion molecule-1] , intercellular cell adhesion molecule-1 , monocyte chemoattractant protein-1 , interleukin-8 , and the cytokine mediated adhesion of monocytes to ECs . Positive_regulation VCAM1 TNF 18206643 1870566 Transduced Tat-APE1/ref-1 showed inhibitory activity on the *induced* monocyte adhesion and [vascular cell adhesion molecule-1] expression in cultured endothelial cells . Positive_regulation VCAM1 TNF 18221086 1671232 In 1997 , a Glaxo patent described that Troglitazone ( first PPAR-gamma ligand to reach market ) reduced *induced* [VCAM1] expression in HUVECs indicating the potential benefit in atherosclerosis . Positive_regulation VCAM1 TNF 18227124 1895553 We have demonstrated previously that *induced* [VCAM-1] expression is regulated by mitogen activated protein kinases , nuclear factor-kappaB , and p300 activation in HTSMCs . Positive_regulation VCAM1 TNF 18227124 1895554 Here , we investigated whether these different mechanisms participated in *induced* [VCAM-1] expression and enhanced neutrophil adhesion . Positive_regulation VCAM1 TNF 18227124 1895595 These findings revealed that *induced* [VCAM-1] expression via multiple signaling pathways . Positive_regulation VCAM1 TNF 18227515 1864194 Transfection of endothelial cells with an oligonucleotide that decreases miR-126 permits an increase in *stimulated* [VCAM-1] expression . Positive_regulation VCAM1 TNF 18255343 1877297 DHEAS inhibited the *induced* surface expression of [vascular cell adhesion molecule (VCAM)-1] . Positive_regulation VCAM1 TNF 18255343 1877298 The addition of the aromatase inhibitor letrozole had no effect on the inhibition of *induced* [VCAM-1] expression by DHEAS . Positive_regulation VCAM1 TNF 18292233 1885519 In organ culture , *induced* expression of E-selectin , [VCAM-1] , and ICAM-1 on HUVECs but only ICAM-1 on HUAECs . Positive_regulation VCAM1 TNF 18292233 1885544 Transduction of HUVECs with KLF2 reduced mediated *induction* of E-selectin and [VCAM-1] while increasing ICAM-1 induction and reduced transcription factor/co-activator binding to the E-selectin enhancer . Positive_regulation VCAM1 TNF 18295395 1896671 Chondroitin sulfate extracted from the Styela clava tunic suppresses *induced* expression of inflammatory factors , [VCAM-1] and iNOS by blocking Akt/NF-kappaB signal in JB6 cells . Positive_regulation VCAM1 TNF 18295395 1896673 Our results showed that CS inhibited *induced* NF-kappaB activation and subsequent [vascular cell adhesion molecule 1] and inducible nitric oxide synthase expressions by blocking Akt signals in JB6 cells . Positive_regulation VCAM1 TNF 18306423 1912032 Additionally , preshearing of hEECs mitigated *induced* [VCAM1] surface expression . Positive_regulation VCAM1 TNF 18387509 1893178 The goal of this study was to investigate the differential effect of hesperidin , hesperidin methyl chalone and phellopterin derived from P. trifoliata ( Rutaceae ) on the *induction* of intercellular adhesion molecule-1 ( ICAM-1 ) and [vascular cell adhesion molecule-1] ( VCAM-1 ) by and the possible molecular mechanisms by which they differentially regulate ICAM-1 and VCAM-1 expressions . Positive_regulation VCAM1 TNF 18387509 1893182 Stimulation of human umbilical vein endothelial cells ( HUVECs ) with *resulted* in the increase of ICAM-1 and [VCAM-1] expressions , while pretreatment with the three components completely inhibited VCAM-1 expression in a dose dependent manner but had no effect on ICAM-1 expression . Positive_regulation VCAM1 TNF 18387509 1893185 Furthermore , they efficiently inhibited the phosphorylation of Akt and PKC , suggesting that Akt or PKC pathways are an important target by which these compounds regulate *induced* [VCAM-1] but not ICAM-1 . Positive_regulation VCAM1 TNF 18387509 1893187 Taken together , hesperidin , hesperidin methyl chalone and phellopterin reduce *induced* [VCAM-1] expression through regulation of the Akt and PKC pathway , which contributes to inhibit the adhesion of monocytes to endothelium . Positive_regulation VCAM1 TNF 18423409 1920615 DAHP reduced the levels of both BH ( 4 ) and [VCAM-1] *induced* by and IFN-gamma . Positive_regulation VCAM1 TNF 18449215 1951501 In human endothelial cells , ARE-driven HO-1 overexpression inhibited nuclear factor-kappaB activation and subsequent [vascular cell adhesion molecule-1] expression *induced* by . Positive_regulation VCAM1 TNF 18490752 1916990 Anthrax lethal toxin enhances *induced* endothelial [VCAM-1] expression via an IFN regulatory factor-1 dependent mechanism . Positive_regulation VCAM1 TNF 18490752 1916991 In this study , we report that LT amplification of *induced* [VCAM-1] expression is driven transcriptionally by the cooperative activation of NF-kappaB and IFN regulatory factor-1 (IRF-1) . Positive_regulation VCAM1 TNF 18602074 1935552 Bisacurone dose-dependently inhibited *mediated* expression of [VCAM-1] . Positive_regulation VCAM1 TNF 18653650 1992656 IFN-beta significantly enhanced the expression of [vascular cell adhesion molecule-1] and intercellular adhesion molecule-1 on HUVECs in the *presence* of . Positive_regulation VCAM1 TNF 18656701 1942658 could significantly *induce* CCL2 , ICAM-1 and [VCAM-1] expression of PTEC . Positive_regulation VCAM1 TNF 18656701 1942688 Selective inhibitors of p38 MAPK ( SB203580 ) , JNK ( SP600125 ) and ERK ( PD98059 ) could suppress TNF-alpha induced CCL2 and ICAM-1 expression , while only p38 MAPK and ERK inhibitors could suppress *induced* [VCAM-1] expression . Positive_regulation VCAM1 TNF 18755353 1956455 Pioglitazone repressed endothelial *induced* [VCAM-1] messenger ribonucleic acid expression and promoter activity , and induced hepatic IkappaBalpha in a manner dependent on both pioglitazone exposure and PPARalpha expression . Positive_regulation VCAM1 TNF 18981156 1983455 HDL and sphingosine 1-phosphate (S1P) , a bioactive lipid component of the lipoprotein , inhibited *induced* expression of [VCAM-1] , which was associated with NO synthase (NOS) activation , in human umbilical venous endothelial cells . Positive_regulation VCAM1 TNF 18981572 1983602 Ginsenoside Rb1 inhibits *induced* [vascular cell adhesion molecule-1] expression in human endothelial cells . Positive_regulation VCAM1 TNF 18981572 1983604 We investigated whether ginsenoside Rb1 ( Rb1 ) could block *induced* over-expression of [vascular cell adhesion molecule-1] ( VCAM-1 ) in human umbilical vein endothelial cells ( HUVECs ) and human lung microvascular endothelial cells ( HMVECs-L ) . Positive_regulation VCAM1 TNF 18981572 1983612 In conclusion , Rb1 effectively blocked the *induced* over-expression of [VCAM-1] , increased THP-1 adhesion and over production of superoxide anion . Positive_regulation VCAM1 TNF 18983508 2015209 Endothelial phenotype of BOEC was evaluated by fluorescence activated cell sorting ( FACS ) analysis and confirmed the presence of endothelial markers including CD31 , CD105 , CD144 , CD146 , KDR/VEGFR-2 , Tie-2 , and *induced* [VCAM-1] and ICAM-1 . Positive_regulation VCAM1 TNF 18989464 1983817 This study investigated the *induced* ICAM-1 and [VCAM-1] expression on mouse lingual lymphatic vessels . Positive_regulation VCAM1 TNF 19004511 2216455 We assessed the effect of SSRIs , ( citalopram , fluvoxamine and fluoxetine ) , on *induced* expression of [VCAM-1] and ICAM-1 in human aorta endothelial cells and adhesiveness to U937 monocytes . Positive_regulation VCAM1 TNF 19004511 2216457 SSRIs decreased the *induced* endothelial expression of [VCAM-1] at concentration range 10 ( -7 ) M to 10 ( -4 ) M ( p < 0.05 ) . Positive_regulation VCAM1 TNF 19104177 2018755 Midazolam significantly inhibited *induced* [vascular cell adhesion molecule-1] and monocyte adhesion in a dose dependent manner ( 1-30 microM ) . Positive_regulation VCAM1 TNF 19104177 2018756 The midazolam mediated suppression on the *induced* [vascular cell adhesion molecule-1] expression and monocyte adhesion were inhibited by the pretreatment of PK11195 and not inhibited by the flumazenil . Positive_regulation VCAM1 TNF 19104177 2018757 Midazolam mediated suppression on the *induced* [vascular cell adhesion molecule-1] expression was abrogated by the transfection of small interfering RNA for PBR . Positive_regulation VCAM1 TNF 19236958 2054783 In addition , withaferin A inhibited *induced* expression of adhesion molecules ( ICAM-1 and [VCAM-1] ) protein and mRNA in a dose dependent manner . Positive_regulation VCAM1 TNF 19238330 2093609 By contrast , over-expression of a dominant negative SK inhibited the *induced* [VCAM-1] and E selectin and inhibited PMN adhesion , confirming that the observed effects were specifically mediated by SK . Positive_regulation VCAM1 TNF 19277846 2106023 Sulforaphane inhibits *induced* activation of p38 MAP kinase and [VCAM-1] and MCP-1 expression in endothelial cells . Positive_regulation VCAM1 TNF 19284655 2055710 The *induction* of the expression of endothelial [VCAM-1] , ICAM-1 and E-selectin by was concentration-dependently reduced by incubation of the endothelial cells with the arginase inhibitor L-norvaline . Positive_regulation VCAM1 TNF 19284655 2055714 Silencing S6K1 prevented up-regulation of E-selectin , but not that of [VCAM-1] or ICAM-1 *induced* by . Positive_regulation VCAM1 TNF 19325144 2080381 activation of siDHCR24 treated cells *increased* expression of [VCAM-1] ( 550-fold , P < 0.001 ) and NF-kappaB ( 9-fold , P < 0.001 ) that could no longer be suppressed by rHDLs . Positive_regulation VCAM1 TNF 19356108 2007932 Increased adiponectin levels were associated with a decrease in *induced* ICAM-1 and [VCAM-1] and caspase 3 activity in endothelial cells while phosphorylation of eNOS at Ser-1179 increased . Positive_regulation VCAM1 TNF 19367378 2081650 Reverse transcription-PCR and Western blot analyses revealed that Klotho suppressed *induced* expression of intracellular adhesion molecule-1 ( ICAM-1 ) and [vascular cell adhesion molecule-1] ( VCAM-1 ) . Positive_regulation VCAM1 TNF 19389799 2100747 These inhibitory responses of GW501516 on activated endothelium were accompanied by a reduction in *induced* endothelial GRO-alpha release and [VCAM-1] , E-selectin , and ICAM-1 mRNA expression . Positive_regulation VCAM1 TNF 19401198 2089525 Interestingly , H ( 2 ) O ( 2 ) -stimulated NF-kappaB-luciferase activity and *induced* expression of [vascular cell adhesion molecule-1] ( VCAM-1 ) and intracellular adhesion molecule-1 ( ICAM-1 ) expressions in human umbilical vein endothelial cells ( HUVEC ) were significantly inhibited by CTS . Positive_regulation VCAM1 TNF 19420112 2106633 However , the broad-spectrum caspase inhibitor Boc-d-fmk reduced NF-kB activation as assessed by gel shift assay , reduced phosphorylation of subunit IkappaBalpha , and significantly inhibited *induced* expression of ICAM-1 and [VCAM-1] as assessed by both real-time PCR and flow cytometry . Positive_regulation VCAM1 TNF 19439196 2101369 Experimental results indicated that 2-TeCD suppressed the *induced* the expression of [vascular adhesion molecule-1 (VCAM-1)] and intercellular cell adhesion molecule-1 ( ICAM-1 ) on HUVECs surface in a dose dependent manner . Positive_regulation VCAM1 TNF 19439196 2101372 In short , these results indicated that 2-TeCD inhibits *stimulated* [VCAM-1] and ICAM-1 expression in HUVECs partly due to suppressing translocation of NF-kappaB . Positive_regulation VCAM1 TNF 19443199 2264124 We compared the abilities of alpha- , gamma- and delta-tocopherols to regulate human blood cytotoxicity ( BEC ) and lymphatic endothelial cytotoxicity ( LEC ) , proliferation , invasiveness , permeability , capillary formation and suppression of *induced* [VCAM-1] as in vitro models of inflammatory angiogenesis . Positive_regulation VCAM1 TNF 19443199 2264125 Lastly , in BEC , alpha- , gamma- and delta-tocopherol each dose-dependently reduced *induced* expression of [VCAM-1] . Positive_regulation VCAM1 TNF 19443199 2264126 In LEC , there was no significant change to *induced* [VCAM-1] expression with any concentration of alpha- , gamma- or delta-tocopherol . Positive_regulation VCAM1 TNF 19520742 2108827 (LPS) *induced* [VCAM-1] expression in HIMEC was suppressed by Akt small interfering RNA , curcumin , and inhibitors of NF-kappaB ( SN-50 ) , p38 MAPK ( SB-203580 ) and PI 3-kinase/Akt ( LY-294002 ) . Positive_regulation VCAM1 TNF 19523446 2103168 In HUVEC cells , UCB blunted the *induced* gene upregulation of E-selectin [VCAM-1] and ICAM-1 . Positive_regulation VCAM1 TNF 19523846 2109023 Scabies extract down-regulated the *induced* expression of [VCAM-1] by HMVEC-D and this down-regulation still occurred in the presence of the other proinflammatory cytokines , histamine or the lipid derived mediators . Positive_regulation VCAM1 TNF 19539051 2149497 HUVECs treated with alpha-iso-cubebene showed markedly suppressed *induced* mRNA expression of [VCAM-1] and E-selectin , but little alteration in ICAM-1 mRNA expression . Positive_regulation VCAM1 TNF 19539051 2149499 alpha-iso-Cubebene treatment also significantly decreased the *induced* cell surface and total protein expression of [VCAM-1] and E-selectin without affecting ICAM-1 expression . Positive_regulation VCAM1 TNF 19541467 2142426 In this study , we investigated the effect of paeonol on *induced* [VCAM-1] expression in rat aortic endothelial cells ( RAECs ) . Positive_regulation VCAM1 TNF 19541467 2142427 Paeonol inhibited *induced* [VCAM-1] expression in a concentration dependent manner . Positive_regulation VCAM1 TNF 19571567 2162505 To investigate the mechanism of the inhibitory action of procaterol , *induced* expression of adhesion molecules , ICAM-1 and [VCAM-1] , in NHLF was also evaluated . Positive_regulation VCAM1 TNF 19590508 2130062 Telmisartan dose dependently diminished the *induced* gene expression of [VCAM-1] , and GW9662 did not attenuate this effect . Positive_regulation VCAM1 TNF 19607809 2123916 OA-NO ( 2 ) and LNO ( 2 ) also blocked *induced* expression of the adhesion molecules , ICAM-1 , [VCAM-1] , and E-selectin , and suppressed monocyte adhesion to HUVECs . Positive_regulation VCAM1 TNF 19608869 2112254 In addition , HO-1 overexpression inhibited *induced* intercellular adhesion molecule-1 and [vascular cell adhesion molecule-1] expression , adherence of THP-1 cells , generation of interleukin-6 , p47(phox) translocation , and nuclear factor-kappaB activation . Positive_regulation VCAM1 TNF 19617655 2112462 Pretreatment of HUVEC with propionate significantly inhibited the *induced* expression of [vascular cell adhesion molecule-1] ( VCAM-1 ) and intracellular adhesion molecule-1 ( ICAM-1 ) in a time- and dose dependent manner . Positive_regulation VCAM1 TNF 19617655 2112464 At 10 mM , propionate also inhibited the interleukin-1 (IL- 1) mediated VCAM-1 and ICAM-1 expression , with the latter effect being more pronounced , as well as decreased the *induced* [VCAM-1] and ICAM-1 mRNA expression in a similar manner . Positive_regulation VCAM1 TNF 19627149 2180251 Anthocyanins from black soybean seed coats preferentially inhibit *mediated* induction of [VCAM-1] over ICAM-1 through the regulation of GATAs and IRF-1 . Positive_regulation VCAM1 TNF 19627149 2180256 Stimulation of cells with *increased* ICAM-1 and [VCAM-1] expression , and pretreatment with anthocyanins inhibited VCAM-1 expression , but not ICAM-1 expression . Positive_regulation VCAM1 TNF 19627149 2180258 We found that IRF-1 and GATAs , especially GATA-4 and -6 , were involved in the *mediated* expression of [VCAM-1] but not ICAM-1 , and anthocyanins decreased nuclear levels of GATA-4 and GATA-6 as well as IRF-1 . Positive_regulation VCAM1 TNF 19627149 2180264 Moreover , pretreatment with a Jak/STAT inhibitor decreased *induced* [VCAM-1] expression and nuclear GATA-4 , GATA-6 , and IRF-1 levels . Positive_regulation VCAM1 TNF 19627149 2180268 This suggests that anthocyanins differentially regulate *mediated* expression of [VCAM-1] and ICAM-1 through modulation of the GATA and IRF-1 binding activity via Jak/STAT-3 activation . Positive_regulation VCAM1 TNF 19801900 2148234 Furthermore , vaspin did not decrease the ( 24 hr ) *induction* of [vascular cell adhesion molecule-1] , intercellular adhesion molecule-1 , endothelial selectin , and cyclooxygenase-2 protein expression as well as monocyte chemotactic protein-1 , tissue factor , and plasmogen activator inhibitor-1 mRNA expression . Positive_regulation VCAM1 TNF 19875721 2187912 CD31 ( + ) cells purified from differentiating EBs upregulated ICAM-1 and [VCAM-1] in *response* to , confirming their ability to function as endothelial cells . Positive_regulation VCAM1 TNF 19965776 2199568 In HCAECs , both 5A/PLPC and ( A-I ) rHDL inhibited *induced* intercellular adhesion molecule-1 and [vascular cell adhesion molecule-1] expression , as well as the nuclear factor kappaB signaling cascade and production . Positive_regulation VCAM1 TNF 20016245 2200099 The protein and mRNA levels of *induced* ICAM-1 , [VCAM-1] and E-selectin were determined in HUVECs . Positive_regulation VCAM1 TNF 20016245 2200101 Puerarin inhibited the expression of *induced* ICAM-1 , [VCAM-1] and E-selectin proteins and mRNAs in HUVECs . Positive_regulation VCAM1 TNF 20016245 2200104 These data suggested that the effect of puerarin mediated inhibition of *induced* ICAM-1 , [VCAM-1] and E-selectin expression is attributed to suppressed NF-kappaB activation on the transcriptional level . Positive_regulation VCAM1 TNF 20039412 2192617 Involvement of MAPKs and NF-kappaB in alpha *induced* [vascular cell adhesion molecule 1] expression in human rheumatoid arthritis synovial fibroblasts . Positive_regulation VCAM1 TNF 20039412 2192624 To investigate the roles of MAPKs and NF-kappaB in *induced* expression of [vascular cell adhesion molecule 1] ( VCAM-1 ) in human rheumatoid arthritis synovial fibroblasts ( RASFs ) . Positive_regulation VCAM1 TNF 20039412 2192629 The involvement of MAPKs and NF-kappaB in *induced* [VCAM-1] expression was investigated using pharmacologic inhibitors and transfection with short hairpin RNA ( shRNA ) and measured using Western blot , reverse transcriptase-polymerase chain reaction , and gene promoter assay . Positive_regulation VCAM1 TNF 20039412 2192705 [VCAM-1] promoter activity was *enhanced* by in RASFs transfected with VCAM-1-Luc , and this promoter activity was inhibited by Bay11-7082 , U0126 , SB202190 , and SP600125 . Positive_regulation VCAM1 TNF 20039412 2192706 In RASFs , *induced* [VCAM-1] expression is mediated through activation of the p42/p44 MAPK , p38 MAPK , JNK , and NF-kappaB pathways . Positive_regulation VCAM1 TNF 20069129 2177870 In this study , we found that ticlopidine dose-dependently decreased the mRNA and protein levels of *stimulated* MCP-1 , IL-8 , and [vascular cell adhesion molecule-1] ( VCAM-1 ) in human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation VCAM1 TNF 20069129 2177876 These results suggest that ticlopidine decreased *induced* MCP-1 , IL-8 , and [VCAM-1] levels in HUVECs , and monocyte adhesion . Positive_regulation VCAM1 TNF 20156602 2236154 In addition , BAI inhibited *induced* expression of adhesion molecules ( ICAM-1 and [VCAM-1] ) protein and mRNA in a dose dependent manner . Positive_regulation VCAM1 TNF 20181103 2222762 This correlates with increased translocation of the transcription factor NF-kB to the nucleus , which is known to regulate ICAM-1 , [VCAM-1] and E-selectin expression in *response* to . Positive_regulation VCAM1 TNF 20360250 2255227 In HCAECs , maneuvers that prevent Ca ( 2+ ) influx or knockdown of TRPC3 markedly reduced *induced* [VCAM-1] and monocyte adhesion . Positive_regulation VCAM1 TNF 20360250 2255231 Stable ( HEK293 cells ) or transient ( HCAECs ) overexpression of TRPC3 enhanced *induced* [VCAM-1] compared to wild-type cells . Positive_regulation VCAM1 TNF 20368952 1841304 It was found that resveratrol inhibited the *activated* endothelial expression of [vascular cell adhesion molecule-1] in a dose dependent manner . Positive_regulation VCAM1 TNF 20378716 2273546 Immunoblot assays demonstrated a significant reduction in *stimulated* E-selectin , [VCAM-1] , and ICAM-1 proteins after inhibition or knockdown of NQO1 . Positive_regulation VCAM1 TNF 20550948 2289940 Previously , we have shown that phenyl methimazole ( C10 ) markedly decreases virally induced TLR-3 expression and signaling and potently inhibits both *induced* [VCAM-1] expression and the resultant leukocyte-endothelial cell adhesion . Positive_regulation VCAM1 TNF 20557886 2308776 Q-real-time PCR and protein array approaches confirmed that *induced* ICAM-1 , [VCAM-1] and ELAM-1 as well as MCP-1 and IL-6 induction was affected upon 3beta-Adiol pre-incubation . Positive_regulation VCAM1 TNF 20558233 2302439 beta-sitosterol also significantly inhibited the *induced* expression of [VCAM-1] and E-selectin , which also play key role in various inflammatory diseases . Positive_regulation VCAM1 TNF 20561987 2285202 MCP induced protein 1 suppresses *induced* [VCAM-1] expression in human endothelial cells . Positive_regulation VCAM1 TNF 20562516 2290143 An Akt inhibitor , LY294002 , and an NF-kappaB inhibitor , pyrrolidine dithiocarbamate , inhibited *induced* [VCAM-1] . Positive_regulation VCAM1 TNF 20562516 2290150 An antioxidant drug , N-acetyl-L-cysteine (NAC) inhibited *induced* [VCAM-1] . Positive_regulation VCAM1 TNF 20562516 2290161 A CaM inhibitor , W-7 , and a calcium/CaM dependent protein kinase type II inhibitor , KN93 , inhibited *induced* [VCAM-1] . Positive_regulation VCAM1 TNF 20562516 2290168 The present results indicate that in vascular SMCs , CV-159 inhibits *induced* [VCAM-1] through inhibition of NF-kappaB and Akt phosphorylation . Positive_regulation VCAM1 TNF 20573493 2375004 These results suggest that DHA negatively regulates *induced* [VCAM-1] expression through attenuation of NF-?B signaling pathway and AP-1 activation . Positive_regulation VCAM1 TNF 20592773 2181646 We recently demonstrated that hyperglycemia increases oxidative stress and HBP flux in endothelial cells and enhances endothelial expression of [vascular adhesion molecule-1 (VCAM-1)] and intercellular adhesion molecule-1 ( ICAM-1 ) in *response* to through oxidative stress rather than HBP pathway . Positive_regulation VCAM1 TNF 20592773 2181650 Here we present further complementary data showing that enhancing O-GlcNAc levels by glucosamine does not mimic hyperglycemia 's effect on *induced* endothelial [VCAM-1] and ICAM-1 expression . Positive_regulation VCAM1 TNF 20623600 2367943 Chloroform extract of aged black garlic attenuates *induced* ROS generation , [VCAM-1] expression , NF-?B activation and adhesiveness for monocytes in human umbilical vein endothelial cells . Positive_regulation VCAM1 TNF 20623600 2367944 HUVECs treated with CEABG showed markedly suppressed *induced* mRNA expression of [VCAM-1] , but little alteration in ICAM-1 and E-selectin mRNA expression . Positive_regulation VCAM1 TNF 20623600 2367945 CEABG treatment also significantly decreased the *induced* cell surface and total protein expression of [VCAM-1] without affecting ICAM-1 and E-selectin expression . Positive_regulation VCAM1 TNF 20687137 2388892 Together , these results suggest that Tan IIA regulates *induced* expression of [VCAM-1] and ICAM-1 through inhibition of NF-?B activation and ROS generation in BMVECs . Positive_regulation VCAM1 TNF 20851151 2368664 Relaxin treatment suppressed significantly induced *upregulation* of [VCAM-1] and PECAM , CCR-2 , and MCP-1 levels and direct monocyte adhesion to HUVEC . Positive_regulation VCAM1 TNF 20877233 2326501 Inhibitory effect of indigo naturalis on *induced* [vascular cell adhesion molecule-1] expression in human umbilical vein endothelial cells . Positive_regulation VCAM1 TNF 20878699 2326558 Preincubation with ATO ( 20 µg/mL ) suppressed *induced* expression of adhesion molecules including intercellular adhesion molecule-1 ( ICAM-1 ) , [vascular cell adhesion molecule-1] ( VCAM-1 ) and E-selectin at both the protein and mRNA levels . Positive_regulation VCAM1 TNF 20932938 2343353 Our results indicate that diosgenin inhibits the adhesive capacity of VSMC and the mediated *induction* of ICAM-1 and [VCAM-1] in VSMC by inhibiting the MAPK/Akt/NF-?B signaling pathway and ROS production , which may explain the ability of diosgenin to suppress inflammation within the atherosclerotic lesion and modulate immune response . Positive_regulation VCAM1 TNF 20937376 2375761 Isoimperatorin , cimiside E and 23-O-acetylshengmanol-3-xyloside from Cimicifugae rhizome inhibit *induced* [VCAM-1] expression in human endothelial cells : involvement of PPAR-? upregulation and PI3K , ERK1/2 , and PKC signal pathways . Positive_regulation VCAM1 TNF 20937376 2375765 The present results show that cimiside E , 23-O-actylshengmanol-3-xyloside , isoimperatorin isolated from Cimicifugae Rhizome selectively inhibits *induced* expression of [VCAM-1] at least by upregulation of PPAR-? , and signals for ERK1/2 , PI3K , and PKC are involved in this effect . Positive_regulation VCAM1 TNF 20946932 2369222 7,8-didehydrocimigenol from Cimicifugae rhizoma inhibits *induced* [VCAM-1] but not ICAM-1expression through upregulation of PPAR-? in human endothelial cells . Positive_regulation VCAM1 TNF 20966071 2354145 Here we show that DNA-PK is required for [VCAM-1] expression in *response* to . Positive_regulation VCAM1 TNF 20966071 2354150 The phosphorylation and subsequent degradation of I-?Ba as well as the serine 536 phosphorylation and nuclear translocation of p65 NF-?B were insufficient for [VCAM-1] expression in *response* to . Positive_regulation VCAM1 TNF 20966071 2354152 The requirement for p50 NF-?B in *induced* [VCAM-1] expression may be associated with its interaction with and phosphorylation by DNA-PK , which appears to be dominant over the requirement for p65 NF-?B activation . Positive_regulation VCAM1 TNF 20969944 2376055 Finally , *mediated* [VCAM-1] expression in endothelial cell was significantly inhibited by MEC . Positive_regulation VCAM1 TNF 21138840 2384302 Finally , in vivo studies show that activation of XBP1 by ER stress preconditioning prevents *induced* ICAM-1 and [VCAM-1] expression , leukostasis , and vascular leakage in mouse retinas . Positive_regulation VCAM1 TNF 21445895 2443712 Immunoblot analysis showed that Monascus fermented rice metabolites significantly attenuated *induced* [VCAM-1] and E-selectin but not ICAM-1 protein expression . Positive_regulation VCAM1 TNF 21445895 2443715 Monascus fermented rice metabolites reduced *stimulated* endothelial adhesiveness as well as downregulating intracellular ROS formation , NF-?B activation , and [VCAM-1/E-selectin] expression in HAECs , supporting the notion that the various metabolites from Monascus fermented rice might have potential implications in clinical atherosclerosis disease . Positive_regulation VCAM1 TNF 21679760 2465318 Further investigations showed that sinomenine and LMS could significantly suppress TNF-a induced phosphorylation of inhibitor ?Ba and extracellular signal regulated protein kinase , the central signaling molecules mediating *induced* [VCAM-1] expression and chemokine production . Positive_regulation VCAM1 TNF 21764059 2500177 In both DN-AMPK- and AMPKa ( 1 ) -siRNA transfected HUVECs , compound C still inhibited *induced* [VCAM-1] and ICAM-1 expression , indicating that this is AMPK independent action . Positive_regulation VCAM1 TNF 21767632 2472356 The *induced* expression of [VCAM-1] was significantly reduced by respectively 38±7 or 34±16 % when HUVECs were pretreated with 10 or 30µM viscolin , as shown by Western blotting , and was also significantly reduced by pretreatment with the antioxidants N-acetylcysteine , diphenylene iodonium chloride , and apocynin . Positive_regulation VCAM1 TNF 21767632 2472357 Viscolin also reduced *induced* [VCAM-1] mRNA expression and promoter activity , decreased reactive oxygen species ( ROS ) production , nicotinamide adenine dinucleotide phosphate ( NADPH) oxidase activity , and significantly reduced the binding of monocytes to TNF-a stimulated HUVECs . Positive_regulation VCAM1 TNF 21767632 2472358 The attenuation of *induced* [VCAM-1] expression and cell adhesion was partly mediated by a decrease in JNK phosphorylation . Positive_regulation VCAM1 TNF 21777697 2509917 ZLJ-6 , a novel COX/5-LOX inhibitor , attenuates *induced* endothelial E-selectin , ICAM-1 and [VCAM-1] expression and monocyte-endothelial interactions via a COX/5-LOX independent mechanism . Positive_regulation VCAM1 TNF 21852236 2490738 JNK or NF?B inhibition attenuated *induction* of ICAM-1 and [VCAM-1] expression in GPx-1-deficient and control cells , whereas ERK1/2 inhibition attenuated only VCAM-1 expression . Positive_regulation VCAM1 TNF 21860594 2469244 Taken together , these results indicate that upregualtion of PPAR-? by genipin selectively inhibits *induced* expression of [VCAM-1] , in which regulation of Akt and/or PKC play a key role . Positive_regulation VCAM1 TNF 21876235 2473900 Treatment with telmisartan decreases the *induced* recruitment of monocytic cells and endothelial expression of [VCAM-1] in regions of non-uniform shear stress in vitro . Positive_regulation VCAM1 TNF 22019447 2513624 In endothelial cells exposed to non-uniform shear stress , VEGFR2 knockdown inhibited induced NF-?B translocation to the nucleus , and the *upregulation* of [VCAM-1] and E-selectin . Positive_regulation VCAM1 TNF 22081437 2568050 The results showed that ( 1 ) *induced* a concentration dependent increase in [VCAM-1] expression in MSCs , whereas the expression of L-selectin , ICAM-1 and VLA-4 did not change significantly . Positive_regulation VCAM1 TNF 22093181 2517372 Insulin augments *stimulated* expression of [vascular cell adhesion molecule-1] in vascular endothelial cells . Positive_regulation VCAM1 TNF 22093255 2548280 Hypoxia and hypoxia mimetics inhibit *dependent* [VCAM1] induction in the 5A32 endothelial cell line via a hypoxia inducible factor dependent mechanism . Positive_regulation VCAM1 TNF 22128776 2520071 When isolated rabbit HDL was pre incubated with human coronary artery endothelial cells ( HCAECs ) , prior to stimulation with TNF-a , it was found that HDL from ETC-642 treated rabbits were more effective at inhibiting the *induced* increase in ICAM-1 , [VCAM-1] and p65 than HDL isolated from saline treated rabbits ( p < 0.05 ) . Positive_regulation VCAM1 TNF 22137262 2636429 EGCG treatment also inhibited *stimulated* expression of [vascular cell adhesion molecule (VCAM)-1] and decreased adhesion of monocytes to HAEC . Positive_regulation VCAM1 TNF 22155163 2568522 In the present study , we investigate the effect of sulforaphane on the expression of [VCAM-1] *induced* by in cultured mouse vascular smooth muscle cell lines . Positive_regulation VCAM1 TNF 22155163 2568523 Pretreatment of VSMCs for 2h with sulforaphane ( 1-5µg/ml ) dose-dependently inhibited *induced* adhesion of THP-1 monocytic cells and protein expression of [VCAM-1] . Positive_regulation VCAM1 TNF 22155163 2568526 This study suggests that sulforaphane inhibits the adhesive capacity of VSMC and downregulates the *mediated* induction of [VCAM-1] in VSMC by inhibiting the MAPK , NF-?B and AP-1 signaling pathways and intracellular ROS production . Positive_regulation VCAM1 TNF 22182512 2543285 Down-regulation of JNK by a specific inhibitor ( SP600125 ) or dominant negative ( DN ) JNK1 plasmid enhanced *induced* [VCAM-1] but not ICAM-1 expression . Positive_regulation VCAM1 TNF 22182512 2543287 Moreover , transfection with a JNK1 overexpressing vector resulted in the inhibition of VCAM-1 expression stimulated by TNF-a in HUVECs , suggesting that JNK negatively regulates *induced* [VCAM-1] expression in endothelial cells ( ECs ) . Positive_regulation VCAM1 TNF 22182512 2543288 Next , we investigated whether JNK signaling affects IRF-1 and/or GATA6 , which are transcription factors that mediate *induction* of [VCAM-1] but not ICAM-1 . Positive_regulation VCAM1 TNF 22183741 2617275 Endometriotic stromal cells treated with curcumin showed marked suppression of *induced* mRNA expression of ICAM-1 and [VCAM-1] . Positive_regulation VCAM1 TNF 22183741 2617277 Curcumin treatment also significantly decreased the *induced* cell surface and total protein expression of ICAM-1 and [VCAM-1] in a dose dependent manner . Positive_regulation VCAM1 TNF 22205391 2575056 Furthermore , LXA ( 4 ) preincubation with human submandibular gland cell line ( HSG ) also blocked *mediated* upregulation of [vascular cell adhesion molecule-1] ( VCAM-1 ) in these cells , and it reduced lymphocyte adhesion . Positive_regulation VCAM1 TNF 22210374 2549837 Pretreatment of VSMCs for 2h with stereocalpin A at nontoxic concentrations of 0.1-10 µg/ml inhibited *induced* adhesion of THP-1 monocytic cells and expression of [vascular cell adhesion molecule-1] ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ) . Positive_regulation VCAM1 TNF 22267843 2559810 We previously showed that thioredoxin interacting protein (TXNIP) was required for *mediated* expression of [vascular cell adhesion molecule-1] . Positive_regulation VCAM1 TNF 22280832 2564967 Pretreatment of VSMCs with ohioensin F at nontoxic concentrations of 0.1-10 µg/ml dose-dependently inhibited *induced* expression of [vascular cell adhesion molecule-1] ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ) . Positive_regulation VCAM1 TNF 22389387 2587487 TSA ( 10 µM , pretreatment for 30 min ) inhibited [VCAM-1] expression and NF-?B phosphorylation *induced* by ( 10 ng/ml , 24 h or 20 min ) in SMCs . Positive_regulation VCAM1 TNF 22463742 2668964 Indeed , we found that *induced* [VCAM-1] was reduced with concentrations of PTX in the low nanomolar range , comparable to plasma levels in PTX treated groups . Positive_regulation VCAM1 TNF 22463742 2668965 We also investigated the effect of HIV proteins and found that HIV transactivator of transcription ( HIV-Tat ) and HIV-envelope derived recombinant gp120 enhanced *induced* [VCAM-1] gene expression in lung microvascular and coronary macrovascular endothelial cells , respectively . Positive_regulation VCAM1 TNF 22465119 2583189 Finally , potently *induced* ICAM-1 and [VCAM-1] expression in both SV-EC and SV-SMC . Positive_regulation VCAM1 TNF 22471363 2578684 It was demonstrated that ( i ) long-chain saturated fatty acids were higher and the n-3/n-6 fatty acid ratio was significantly lower for P-407 HDL compared with control HDL , and ( ii ) P-407 HDL lost its capacity to inhibit *induced* [vascular cell adhesion molecule-1] ( VCAM-1 ) expression compared with control HDL . Positive_regulation VCAM1 TNF 22536886 2686596 strongly *increased* the expression of [VCAM-1] and ICAM-1 accompanied by increased expression of p-i?B and NF-?B proteins . Positive_regulation VCAM1 TNF 22554771 2608574 Both inhibitor of p38 ( SB203580 ) and JNK ( SP600125 ) significantly inhibited *induced* [VCAM-1] expression . Positive_regulation VCAM1 TNF 22554771 2608579 The present results demonstrate for the first time that omentin plays an anti-inflammatory role by preventing the *induced* [VCAM-1] expression in SMCs . Positive_regulation VCAM1 TNF 22554771 2608581 It is suggested that omentin inhibits *induced* [VCAM-1] expression via preventing the activation of p38 and JNK at least in part through inhibition of superoxide production . Positive_regulation VCAM1 TNF 22609006 2632293 Keap1 knockdown inhibited *induced* expression of intracellular adhesion molecule-1 ( ICAM-1 ) and vascular cell adhesion molecule-1 ( [VCAM-1] ) by suppressing NF-?B activation via inhibition of its upstream modulators , Akt , NIK , and IKK , resulting in the elevation of monocyte adhesion to endothelial cells . Positive_regulation VCAM1 TNF 22616995 2603980 Moreover , *induced* [VCAM-1] expression is suppressed by VDAC-1 gene silencing . Positive_regulation VCAM1 TNF 22634313 2614843 Pretreatment with chemerin ( 1-300 ng/ml , 24 h ) significantly inhibited phosphorylation of nuclear factor ( NF ) -?B p65 ( Ser536 ) and p38 as well as [vascular cell adhesion molecule (VCAM)-1] expression *induced* by ( 5 ng/ml , 20 min-6 h ) . Positive_regulation VCAM1 TNF 22634313 2614844 Inhibitor of NF-?B or p38 significantly inhibited the *induced* [VCAM-1] expression . Positive_regulation VCAM1 TNF 22634313 2614846 Chemerin also inhibited *induced* [VCAM-1] expression in rat isolated aorta . Positive_regulation VCAM1 TNF 22634313 2614847 The inhibitory effect of chemerin on *induced* [VCAM-1] was reversed by a NOS inhibitor . Positive_regulation VCAM1 TNF 22634313 2614848 Conversely , an NO donor , sodium nitroprusside significantly inhibited *induced* [VCAM-1] . Positive_regulation VCAM1 TNF 22634313 2614849 The present results for the first time demonstrate that chemerin plays anti-inflammatory roles by preventing *induced* [VCAM-1] expression and monocytes adhesion in vascular endothelial cells . Positive_regulation VCAM1 TNF 22661092 2615444 RXR agonists also prevented *induced* [VCAM-1] and ICAM-1 expression , as well as endothelial growth related oncogene-a and MCP-1 release . Positive_regulation VCAM1 TNF 22708120 2616092 Quantitative reverse transcriptase PCR and Western blot analyses indicated that IL-33 mediates the expression of intercellular adhesion molecule (ICAM)-1 and [vascular cell adhesion molecule (VCAM)-1] in endothelial cells basally and in *response* to . Positive_regulation VCAM1 TNF 22734001 2621557 We report that pharmacological FAK inhibition prevented *induced* [VCAM-1] expression within heart vessel associated endothelial cells in vivo , and genetic or pharmacological FAK inhibition blocked VCAM-1 expression during development . Positive_regulation VCAM1 TNF 22734001 2621558 FAK signaling facilitated TNF-a induced , mitogen activated protein kinase activation , and , surprisingly , FAK inhibition resulted in the loss of the GATA4 transcription factor required for *induced* [VCAM-1] production . Positive_regulation VCAM1 TNF 22841897 2682359 Pretreatment with 1a,25- ( OH ) ( 2 ) D ( 3 ) significantly inhibited *induced* [VCAM-1] expression and IL-8 production in HCAECs . Positive_regulation VCAM1 TNF 22842465 2646574 Our data showed that omentin decreased *induced* expression of ICAM-1 and [VCAM-1] in HUVECs . Positive_regulation VCAM1 TNF 22842465 2646577 Omentin , NF-kB inhibitor ( BAY11-7082 ) and ERK inhibitor ( PD98059 ) reduced the up-regulation of ICAM-1 and [VCAM-1] *induced* by . Positive_regulation VCAM1 TNF 22862554 2641075 Stimulation of a human bronchial epithelial cell line ( BEAS-2B ) with *increased* the expression of surface adhesion molecules , including intercellular adhesion molecule 1 ( ICAM-1 ) and [vascular cell adhesion molecule 1] ( VCAM-1 ) , in which eupatilin significantly inhibited the expression of those adhesion molecules in a dose dependent manner . Positive_regulation VCAM1 TNF 22898620 2687667 Sulforaphane inhibited the mRNA and protein expression of [VCAM-1] *induced* by in VSMCs . Positive_regulation VCAM1 TNF 23006728 2689246 Here , we found that reduction of [ Cl ( - ) ] ( i ) increased *induced* expression of intercellular adhesion molecule 1 and [vascular cell adhesion molecule 1] and adhesion of monocytes to endothelial cells ( P < 0.05 ; n=6 ) . Positive_regulation VCAM1 TNF 23035855 2716429 In addition , the effects of total flavonoids on inflammatory molecule expression of cells were tested by immunohistochemistry staining , showing that *induced* expression of PCNA , NF-?B p65 , ICAM-1 , and [VCAM-1] in VSMCs was dose-dependently suppressed by total flavonoids . Positive_regulation VCAM1 TNF 23066037 2720865 It is well known that *induces* [VCAM-1] expression via the NF-?B signaling pathway . Positive_regulation VCAM1 TNF 23066037 2720866 Parthenolide has an anti-inflammatory activity and suppressed NF-?B activity by inhibition of I?Ba phosphorylation after TNF-a stimulation and strongly inhibited *induced* [VCAM-1] expression on MSCs . Positive_regulation VCAM1 TNF 23085565 2703487 Tanshinone IIA inhibits *mediated* induction of [VCAM-1] but not ICAM-1 through the regulation of GATA-6 and IRF-1 . Positive_regulation VCAM1 TNF 23085565 2703489 The goal of this study was to investigate the differential effect of tanshinone IIA on the *induction* of intercellular adhesion molecule-1 ( ICAM-1 ) and [vascular cell adhesion molecule-1] ( VCAM-1 ) by and the possible molecular mechanisms by which it regulates ICAM-1 and VCAM-1 expression differentially . Positive_regulation VCAM1 TNF 23085565 2703495 Stimulation of human umbilical vein endothelial cells ( HUVEC ) with *increased* ICAM-1 and [VCAM-1] expressions , and the pretreatment with tanshinone IIA concentration dependently inhibited VCAM-1 expression but not ICAM-1 expression . Positive_regulation VCAM1 TNF 23085565 2703497 In previous study , PI3K/Akt , PKC and Jak/STAT-3 pathways were involved in the *mediated* induction of [VCAM-1] but not ICAM-1 . Positive_regulation VCAM1 TNF 23085565 2703510 Taken together , tanshinone IIA selectively inhibits *mediated* expression of [VCAM-1] but not ICAM-1 through modulation of PI3/Akt , PKC and Jak/STAT-3 pathway as well as IRF-1 and GATA-6 binding activity . Positive_regulation VCAM1 TNF 23243449 2708707 In addition , these inhibitors reversed the suppressive effect of KGBE on *mediated* induction of ICAM-1 and [VCAM-1] , resulting in decreased interaction between endothelial cells and monocytes . Positive_regulation VCAM1 TNF 23317476 2870148 Whereas IRW significantly inhibited induced *up-regulation* of intercellular cell adhesion molecule-I ( ICAM-1 ) and [vascular cell adhesion molecule-I] ( VCAM-1 ) , IQW could inhibit only the up-regulation of ICAM-1 . Positive_regulation VCAM1 TNF 23608189 2795236 To elucidate the molecular mechanisms involved in these effects , we investigated the effect of statins on *induced* ROS production , [vascular cell adhesion molecule-1] ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ) expression in human aortic endothelial cells ( HAECs ) . Positive_regulation VCAM1 TNF 23608189 2795238 The Rac-1 activation and ROS liberation mediated *stimulated* NF-?B activation and the subsequent [VCAM-1] and ICAM-1 expression . Positive_regulation VCAM1 TNF 23608189 2795242 In addition , pretreatment with atorvastatin inhibited *induced* ROS production and [VCAM-1] and ICAM-1 expression . Positive_regulation VCAM1 TNF 23608189 2795245 Chemical or genetic inhibition of ERK5 ablated the statins inhibition of Rac-1 activation , ROS formation , NF-?B , [VCAM-1] and ICAM-1 expression *induced* by . Positive_regulation VCAM1 TNF 23619297 2795422 In human umbilical vein endothelial cells , TLCA significantly reduced *induced* adhesion of monocytes , [vascular cell adhesion molecule-1] expression , and activation of nuclear factor-?B . Positive_regulation VCAM1 TNF 23619991 2790356 Remarkably , the treatment of the HESCs with HEABG potently suppressed the *induced* ICAM-1 and [VCAM-1] transcript and protein expression by inhibiting the activation of NF-?B and AP-1 transcription factors . Positive_regulation VCAM1 TNF 23632129 2790688 Largazole , a class I histone deacetylase inhibitor , enhances *induced* ICAM-1 and [VCAM-1] expression in rheumatoid arthritis synovial fibroblasts . Positive_regulation VCAM1 TNF 23632129 2790697 In the present study , we evaluated the effect of largazole (LAR) , a marine derived class I HDAC inhibitor , on *induced* expression of intercellular adhesion molecule-1 ( ICAM-1 ) and [vascular cell adhesion molecule-1] ( VCAM-1 ) , and matrix metalloproteinase-2 (MMP-2) activity . Positive_regulation VCAM1 TNF 23632129 2790713 Pretreatment of RA synovial fibroblasts with LAR further enhanced *induced* ICAM-1 and [VCAM-1] expression . Positive_regulation VCAM1 TNF 23632129 2790719 Further , the addition of HDAC6 specific inhibitor Tubastatin A with LAR suppressed *induced* ICAM-1 and [VCAM-1] expression and completely blocked MMP-2 activity , suggesting a role of HDAC6 in LAR induced ICAM-1 and VCAM-1 expression . Positive_regulation VCAM1 TNF 23685156 2801243 Interestingly , treatment with recombinant human APE1/Ref-1 protein ( 2-5 µg/ml for 18 h ) inhibited *induced* [vascular cell adhesion molecule-1] expression in human umbilical vein endothelial cells . Positive_regulation VCAM1 TNF 23728723 2819777 ( 1-80 ng/mL ) *caused* dose- and time dependent increases of ICAM-1 and [VCAM-1] expression in HUVECs , accompanied by significant augmentation of I?B phosphorylation and NF-?B translocation into the nuclei . Positive_regulation VCAM1 TNF 23892569 2839560 Glucocorticoid induced receptor family related ligand triggering *upregulates* [vascular cell adhesion molecule-1] and intercellular adhesion molecule-1 and promotes leukocyte adhesion . Positive_regulation VCAM1 TNF 23929007 2840716 Conversely , *induced* expression of intercellular adhesion molecule 1 , [vascular cell adhesion molecule 1] and E-selectin is markedly inhibited in endothelial cells isolated from aB-crystallin-deficient mice . Positive_regulation VCAM1 TNF 23934855 2850126 Shear stress modulates [VCAM-1] expression in *response* to and dietary lipids via interferon regulatory factor-1 in cultured endothelium . Positive_regulation VCAM1 TNF 23934855 2850129 Shear stress alone modulated *induced* [VCAM-1] expression , eliciting a 150 % increase at low shear stress ( 2 dyn/cm ( 2 ) ) and a 70 % decrease at high shear stress ( 12 dyn/cm ( 2 ) ) relative to static . Positive_regulation VCAM1 TNF 23963020 2855710 These findings indicated that macrophages infiltration into the DRG was dependent , and might be partly *mediated* by [VCAM-1] in the early stage of experimental lumbar disc herination . Positive_regulation VCAM1 TNF 24006483 2856236 Human Jurkat T-cells lacking CD47 also showed reduced adhesion to *activated* endothelium and ICAM-1 and [VCAM-1] . Positive_regulation VCAM1 TNF 24098382 2852218 This includes blockade of *induced* expression of pro-inflammatory cell adhesion ( Icam-1 , Vcam-1 ) , cytokine ( Il-6 , IL-1b ) , and chemokine ( Mcp-1 , Cx3cl1 ) genes , and expression of [VCAM-1] protein in the intestine . Positive_regulation VCAM1 TNF 24134657 2889349 *increased* ICAM-1 and [VCAM-1] expression via c-Jun NH2 -terminal kinase (JNK) , extracellular signal regulated kinase ( ERK1/2 ) and p38 MAPK . Positive_regulation VCAM1 TNF 24213673 2875909 We investigated the role of cytoplasmic APE1/Ref-1 on *induced* [vascular cell adhesion molecule-1] ( VCAM-1 ) expressions in endothelial cells . Positive_regulation VCAM1 TNF 24213673 2875914 Transfection of an N-terminus deletion mutant APE1/Ref-1 ( 29-318 ) inhibited *induced* [VCAM-1] expression , indicating an anti-inflammatory role for APE1/Ref-1 in the cytoplasm . Positive_regulation VCAM1 TNF 24213673 2875915 In contrast , redox mutant of APE1/Ref-1 ( C65A/C93A ) transfection led to increased *induced* [VCAM-1] expression . Positive_regulation VCAM1 TNF 24247297 2886040 Honokiol dose-dependently inhibited *induced* [VCAM-1] expression in BMECs and adhesion of U87MG to BMECs . Positive_regulation VCAM1 TNF 24316968 2894853 Carnosol not only inhibited *induced* protein expression of intercellular adhesion molecule (ICAM)-1 , [vascular cell adhesion molecule (VCAM)-1] and E-selectin in HUVECs , but also suppressed interleukin (IL)-8 and monocyte chemoattractant protein (MCP)-1 expression . Positive_regulation VCAM1 TNF 24333549 2910825 Our results showed that ( TNF-a ) significantly *increased* the protein or mRNA levels of monocyte chemotactic protein-1 (MCP-1) , intercellular adhesion molecule-1 ( ICAM-1 ) , and [vascular cell adhesion molecule-1] ( VCAM-1 ) , whereas pretreatment with Malvidin inhibited TNF-a induced increases of MCP-1 , ICAM-1 , and VCAM-1 production in a concentration dependent manner . Positive_regulation VCAM1 TNF 24333719 2910827 released from LPS treated monocytes *triggered* the expression of intercellular cell adhesion molecule-1 ( ICAM-1 ) and [vascular cell adhesion molecule-1] ( VCAM-1 ) on endothelial cells . Positive_regulation VCAM1 TNF 24355235 2881419 The results showed that the up-regulation of ICAM-1 and [VCAM-1] *induced* by was dose-dependently inhibited by Tanshinone VI , with restoration of control levels at the dose of 40 mM ; Positive_regulation VCAM1 TNF 24470523 2907920 Mechanistic analyses in cultured ECs revealed that Klf4 inhibited *induced* expression of [Vcam1] through blocking the binding of nuclear factor-?B to the Vcam1 promoter . Positive_regulation VCAM1 TNF 24516119 2924092 Rapamycin antagonizes *induction* of [VCAM-1] on endothelial cells by inhibiting mTORC2 . Positive_regulation VCAM1 TNF 24516119 2924093 This functional change was caused by inhibition of *induced* expression of [vascular cell adhesion molecule-1] ( VCAM-1 ) and could be mimicked by knockdown of mammalian target of rapamycin (mTOR) or rictor , but not raptor , implicating mTORC2 as the target of rapamycin for this effect . Positive_regulation VCAM1 TNF 24516119 2924108 Preventing activation of ERK1/2 reduced the ability of rapamycin to inhibit *induced* [VCAM-1] expression . Positive_regulation VCAM1 TNF 24516119 2924109 These changes correlated with reduced endothelial expression of *induced* [VCAM-1] , which was restored via pharmacological inhibition of ERK1/2 . Positive_regulation VCAM1 TNF 24670805 2935006 Moreover , 6-MP and 6-T-GTP selectively decreased *induced* [VCAM-1] but not ICAM-1 protein levels . Positive_regulation VCAM1 TNF 7499419 333115 Transient transfection assays using vascular endothelial cells revealed that site directed mutations in the Sp1 binding element decreased *induced* activity of the [VCAM1] promoter . Positive_regulation VCAM1 TNF 7517980 261803 Thus , UVB selectively upregulates ICAM-1 , but not E-selectin or [VCAM-1] , mRNA and cell surface expression in HDMEC , and this upregulation is not *dependent* upon the autologous secretion and activity of either IL-1 or . Positive_regulation VCAM1 TNF 7522548 269661 PDTC or N-acetylcysteine dose dependently reduced *induced* [VCAM-1] but not ICAM-1 surface protein ( also in human umbilical arterial endothelial cells ) and mRNA expression ( by 70 % at 100 mumol/L PDTC ) in HUVECs as assessed by flow cytometry and polymerase chain reaction . Positive_regulation VCAM1 TNF 7523771 243731 Inflammatory mediators likely to occur under those conditions , e.g. , histamine , thrombin , oxygen derived free radicals (ODFR) , interleukin (IL)-1 , , and activated complement factors , *induce* in a distinct time course the ( transient ) expression of the leukocyte adhesion molecules P-selectin , E-selectin , intercellular adhesion molecule (ICAM)-1 , and [vascular cell adhesion molecule (VCAM)-1] on the endothelium . Positive_regulation VCAM1 TNF 7524649 276775 In parallel with reduced surface VCAM-1 protein expression , DHA reduced [VCAM-1] mRNA *induction* by IL-1 or . Positive_regulation VCAM1 TNF 7525650 276989 Gold sodium thiomalate also suppressed *stimulated* increases in [vascular cell adhesion molecule-1] and E-selectin mRNA levels but had no effect on intercellular adhesion molecule-1 mRNA . Positive_regulation VCAM1 TNF 7526034 277065 We also examined the *mediated* upregulation of E-selectin , [vascular cell adhesion molecule-1] and intercellular adhesion molecule-1 . Positive_regulation VCAM1 TNF 7528721 284144 In addition , data on the intracellular events in *induced* expression of [vascular cell adhesion molecule-1] ( VCAM-1 ) is presented , showing that both PKC and , to a higher extent , calmodulin , are involved in this process . Positive_regulation VCAM1 TNF 7529998 291550 Here , we demonstrate that and IL-1 beta transiently *induced* [VCAM-1] mRNA expression in a time dependent manner . Positive_regulation VCAM1 TNF 7532667 292150 Activation of cAMP dependent pathways in human airway smooth muscle cells inhibits *induced* ICAM-1 and [VCAM-1] expression and T lymphocyte adhesion . Positive_regulation VCAM1 TNF 7532667 292152 In this study , we examined whether an increase in [ cAMP ] i , presumably via activation of cAMP dependent protein kinase , modulates *induced* ICAM-1 and [VCAM-1] on ASM . Positive_regulation VCAM1 TNF 7532667 292158 In addition , treatment with either isoproterenol or prostaglandin E2 , which activates receptors coupled to Gs and increases [ cAMP ] i , also inhibited *induced* expression of ICAM-1 and [VCAM-1] on ASM . Positive_regulation VCAM1 TNF 7533787 296871 Glycated LDL augmented *induced* [VCAM-1] expression 35 % in HAECs but not HUVECs . Positive_regulation VCAM1 TNF 7534663 296994 The *induction* of vascular cell adhesion molecule-1 ( [VCAM-1] ) and E-selectin by is mediated by mobilization of the transcription factor nuclear factor-kappa B (NF-kappa B) . Positive_regulation VCAM1 TNF 7536438 297255 *induced* endothelial E-selectin , intercellular adhesion molecule-1 ( ICAM-1 ) and [vascular cell adhesion molecule-1] ( VCAM-1 ) in all groups , and adhesion molecule expression by interstitial dermal dendritic cells ( ICAM-1 and VCAM-1 ) and keratinocytes ( ICAM-1 ) was observed . Positive_regulation VCAM1 TNF 7536741 300259 markedly *transactivated* a transiently transfected minimal kappa L-kappa R motif-driven [VCAM-1] promoter , p85VCAMCAT , in passaged human vascular endothelial cells but not in the human epithelial cell line , HeLa suggesting that cell type-specific factors may function through the kappa L-kappa R motif . Positive_regulation VCAM1 TNF 7537041 300340 and IL-1 beta but not IFN gamma or IL-6 *induced* [VCAM-1] expression on primary cultured murine hepatocytes in a dose- and a time dependent fashion . Positive_regulation VCAM1 TNF 7538427 301288 Incorporation of the n-3 polyunsaturated fatty acid docosahexaenoic acid ( DHA ) but not eicosapentaenoic acid or n-6 arachidonic acid into human umbilical vein endothelial cell ( HUVEC ) phospholipids dose-dependently reduced *induced* surface expression of [vascular cell adhesion molecule-1] ( VCAM-1 ) . Positive_regulation VCAM1 TNF 7538427 301296 While the PC-PLC inhibitor D609 dose-dependently prevented VCAM-1 induction by TNF-alpha , 1,2-diacyl-glycerol ( DAG ) stimulated VCAM-1 expression , suggesting that [VCAM-1] *induction* by may be mediated by activation of PC-PLC . Positive_regulation VCAM1 TNF 7538427 301298 Incorporation of DHA into phospholipids selectively attenuates [VCAM-1] *induction* by and subsequent monocytic cell adhesion by inhibition of TNF-alpha stimulated PC-PLC activation in HUVECs . Positive_regulation VCAM1 TNF 7541294 310387 The cytokine transforming growth factor-beta ( TGF-beta ) at 2 .0 ng/mL inhibited basal [VCAM-1] expression by 84 +/- 8 % and the *induction* by by between 56 +/- 16 % and 77 +/- 15 % depending on the dose of TNF . Positive_regulation VCAM1 TNF 7541425 310490 *Induction* of [VCAM-1] and ELAM-1 surface expression by was dose-dependently reduced by pretreatment with the protein tyrosine kinase inhibitors herbimycin A ( HMA , IC50 300 nM ) or genistein ( IC50 30 microM ) . Positive_regulation VCAM1 TNF 7541425 310496 Our data suggest that specific phosphorylation following protein tyrosine kinase activation may be required for NF-kappa B mobilization and *induction* of [VCAM-1] and ELAM-1 by . Positive_regulation VCAM1 TNF 7545393 318529 We show that pyrrolidine dithiocarbamate strongly reduces the *mediated* induction of E-selectin , [VCAM-1] , ICAM-1 , PAI-1 , tissue factor , IL-8 and I kappa B-alpha . Positive_regulation VCAM1 TNF 7545397 318535 PD 144795 treatment markedly inhibited the *induced* cell expression of [vascular cell adhesion molecule-1] ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ) protein and mRNA . Positive_regulation VCAM1 TNF 7583580 333555 Steady state mRNA levels of *induced* [VCAM-1] and E-selectin are significantly reduced by physiological concentrations of HDLs . Positive_regulation VCAM1 TNF 7678355 209902 The *stimulated* [VCAM-1] expression is also inhibited by the PKC-specific inhibitor calphostin C. TNF-alphaein synthesis inhibition with cycloheximide ( CHX ) and blocking of transcription with actinomycin D ( ACT D ) also inhibits the VCAM-1 and PMA stimulated upregulation of TNF-alpha . Positive_regulation VCAM1 TNF 7680963 214174 Flow cytometric analyses revealed that murine microvascular endothelium (MME) in culture constitutively expresses [VCAM-1] and that stimulation of MME by , IL-1 , or LPS , but not by PMA or staurosporine , strongly *increased* the surface expression of this cell adhesion molecule . Positive_regulation VCAM1 TNF 7680963 214191 *Stimulation* of [VCAM-1] expression by may be diminished by ionomycin as well as by inhibitors of protein kinases ( H-7 and sangivamycin ) . Positive_regulation VCAM1 TNF 7684420 217584 Elevated cyclic AMP inhibits endothelial cell synthesis and expression of *induced* endothelial leukocyte adhesion molecule-1 , and [vascular cell adhesion molecule-1] , but not intercellular adhesion molecule-1 . Positive_regulation VCAM1 TNF 7684420 217587 Unexpectedly , this combination of cAMP elevating drugs inhibits *induction* of ELAM-1 and [VCAM-1] but not ICAM-1 expression . Positive_regulation VCAM1 TNF 7684420 217591 However , our findings suggest that pharmacological elevations of cAMP in EC , by inhibiting *induced* synthesis of ELAM-1 and [VCAM-1] , could serve to limit inflammation . Positive_regulation VCAM1 TNF 7686753 222290 The PKC inhibitors also reduce *induced* [VCAM-1] expression . Positive_regulation VCAM1 TNF 7691889 231024 Furthermore , PDTC selectively inhibited the *induction* of [VCAM-1] , but not intercellular adhesion molecule-1 ( ICAM-1 ) , mRNA and protein accumulation by the cytokine as well as the noncytokines bacterial endotoxin lipopolysaccharide (LPS) and double stranded RNA , poly ( I:C ) ( PIC ) . Positive_regulation VCAM1 TNF 7691889 231025 PDTC also markedly attenuated *induction* of [VCAM-1] mediated cellular adhesion . Positive_regulation VCAM1 TNF 7691964 231052 Both ELAM-1 and , to a lesser extent , [VCAM-1] expression are *inducible* by , IL-1 , and/or IL-4 on capillaries and larger microvessels at 6 and 24 h . Positive_regulation VCAM1 TNF 7691964 231056 These results with DMEC differ from human umbilical vein EC analyzed in parallel , which are completely CD36- and show transient ELAM-1 and sustained [VCAM-1] expression in *response* to and IL-1 . Positive_regulation VCAM1 TNF 7693806 234198 Venous and arterial large vessel endothelial cells ( EC ) were compared for their constitutive and *induced* expression of the cell-surface adhesion molecules ICAM-1 and -2 , [VCAM-1] and ELAM-1 by FACS analysis . Positive_regulation VCAM1 TNF 7693806 234208 However , *induces* [VCAM-1] cell-surface expression and mRNA only in venous , but not in arterial EC . Positive_regulation VCAM1 TNF 7693806 234213 This increased adhesion is mediated in part by the *induced* [VCAM-1] expression on venous EC . Positive_regulation VCAM1 TNF 7693807 234225 Furthermore , although , preincubation of bEND.3 cells with IFN-gamma modestly increases the induction of ICAM-1 and [VCAM-1] in *response* to and IL-1 , it dramatically reduces the TNF-alpha , IL-1 , and LPS induced expression of MAdCAM-1 . Positive_regulation VCAM1 TNF 8082888 271074 The upregulation of ICAM-1 by IL-1 alpha , TNF-alpha , and IFN-gamma appeared similar , whereas the *induction* of [VCAM-1] by IL-1 alpha , IL-4 , , and IFN-gamma showed differences between the three cell types . Positive_regulation VCAM1 TNF 8194873 259004 *induced* increased expression of ELAM-I and [VCAM-I] adhesion molecules on intratumoral endothelial cells . Positive_regulation VCAM1 TNF 8392131 224769 Surface protein expression of [vascular cell adhesion molecule-1] , endothelial leukocyte adhesion molecule-1 , or intercellular adhesion molecule-1 , which is *induced* by , interleukin-1 , and lipopolysaccharide , was not induced by pentoxyfilline , a phosphodiesterase inhibitor , nor by dibutyryl cyclic adenosine monophosphate . Positive_regulation VCAM1 TNF 8392131 224825 Additionally , activators of the stimulatory or inhibitory guanine nucleotide dependent binding proteins did not affect *induced* surface expression of endothelial leukocyte adhesion molecule-1 or [vascular cell adhesion molecule-1] . Positive_regulation VCAM1 TNF 8537971 346163 *increased* [VCAM-1] expression to 4.2 times the vehicle treated control levels ( P < .05 ) on HT-29 cells and increased ICAM-1 expression on HT-29 , LoVo , and SW-620 cells ( 8.4 , 1.8 , and 1.9 times vehicle control levels , respectively ; Positive_regulation VCAM1 TNF 8547644 346416 We have previously shown that VCAM-1 expression is induced on human umbilical vein EC ( HUVEC ) by both tumor necrosis factor alpha (TNF-alpha) and interleukin-1 alpha (IL-1 alpha) , whereas on human dermal microvascular EC ( HDMEC ) only *results* in [VCAM-1] expression . Positive_regulation VCAM1 TNF 8568264 350970 *induced* sustained [VCAM-1] expression within 4 h in lung , liver , and kidney . Positive_regulation VCAM1 TNF 8568264 350974 The *induced* expression of [VCAM-1] and E-selectin was found to be exclusively controlled by the 55-kDa TNF-receptor ( TNFRp55 ) as demonstrated by analysis of TNFRp55-/- mice . Positive_regulation VCAM1 TNF 8568264 350978 Together , the data suggest that in vivo the 55-kDa receptor *mediates* the induction of [VCAM-1] and E-selectin expression and is critically involved in the control of leukocyte organ infiltration . Positive_regulation VCAM1 TNF 8589921 337540 FACS-analysis revealed PGE1 to inhibit *induced* upregulation of ICAM-1 , but not of [VCAM-1] on EC . Positive_regulation VCAM1 TNF 8596155 342150 Pretreatment with PUVA was also able to prevent subsequent *induction* of [VCAM-1] expression . Positive_regulation VCAM1 TNF 8645302 358639 Transient overexpression of human 15-lipoxygenase in aortic endothelial cells enhances *induced* [vascular cell adhesion molecule-1] gene expression . Positive_regulation VCAM1 TNF 8663191 368408 All three agonists induce de novo expression of E-selectin ( CD62E ) and vascular cell adhesion molecule-1 ( CD106 ) and increase expression of intercellular adhesion molecule-1 ( CD54 ) at 4 h . *induces* sustained increases in [vascular cell adhesion molecule-1] and intercellular adhesion molecule-1 and increases human leukocyte antigen class I molecules at 24 h . Positive_regulation VCAM1 TNF 8665570 368712 These results indicate that serum , raised by surgical stress , is critically *involved* in the enhanced pulmonary metastasis of mouse melanoma by inducing [VCAM-1] expression on lung vascular endothelium . Positive_regulation VCAM1 TNF 8695814 372863 Also , the *induction* of [vascular EC adhesion molecule-1 (VCAM-1)] and E-selectin by was significantly inhibited by prior exposure to bFGF . Positive_regulation VCAM1 TNF 8739563 377098 We demonstrate that the PTK inhibitors herbimycin A or genistein suppress *induction* of endothelial [VCAM-1] and E-selectin , as well as subsequent monocytic cell adhesion to endothelial cells stimulated by . Positive_regulation VCAM1 TNF 8792802 381017 IL-1 beta showed the strongest stimulatory effect on the expression of ICAM-1 , preferentially *induced* the expression of [VCAM-1] and CD-44 , and Et-1 strongly stimulated the upregulation of CD-44 expression . Positive_regulation VCAM1 TNF 8792802 381024 In addition , Et-1 enhanced significantly the IL-1 beta mediated upregulation of VCAM-1 expression , whereas *mediated* expression of [VCAM-1] was downregulated by Et-1 . Positive_regulation VCAM1 TNF 8799163 381943 Moreover , DETA-NO suppressed *induced* mRNA accumulation of [VCAM-1] and TNF-alpha mediated transcriptional activation of the human VCAM-1 promoter . Positive_regulation VCAM1 TNF 8842442 387274 Herbimycin A inhibited both [VCAM-1] and ICAM-1 expression *induced* by . Positive_regulation VCAM1 TNF 8843727 387423 ( TNF-alpha ; 10 ng/ml ) *increased* endothelial ICAM-1 , E-selectin , and [VCAM-1] ; Positive_regulation VCAM1 TNF 8863684 388850 *induced* a genistein-resistant up-regulation of [VCAM-1] . Positive_regulation VCAM1 TNF 8866792 344796 In previous studies we have shown that IL-1 beta and *increase* the expression of ICAM-1 , E-selectin and [VCAM-1] on the cytoplasmatic membranes of HUVECs , HSVECs and HAFECs ( ECs from human umbilical vein , saphenous vein and femoral artery , respectively ) . Positive_regulation VCAM1 TNF 8871646 389581 *induction* of the E-selectin and [vascular cell adhesion molecule-1] ( VCAM-1 ) genes leads to transient accumulation of high levels of mRNA in endothelial cells . Positive_regulation VCAM1 TNF 8977455 403386 Selective inhibition of *induced* [vascular cell adhesion molecule-1] gene expression by a novel flavonoid . Positive_regulation VCAM1 TNF 8977455 403387 A flavonoid , 2- ( 3-amino-phenyl ) -8-methoxy-chromene-4-one ( PD 098063 ) , markedly inhibited *induced* [VCAM-1] cell-surface expression in a concentration dependent fashion with half-maximal inhibition at 19 mumol/L but had no effect on ICAM-1 expression . Positive_regulation VCAM1 TNF 9008098 405034 Cell surface enzyme immunoassay showed that INFnu , IL-1beta , or *stimulated* expression of ICAM-1 , or [VCAM-1] on MC after 24 hours . Positive_regulation VCAM1 TNF 9012737 411079 This fatty acid induced inhibitory activity was reflected in the ability of the mediators to decrease the *induced* expression of the following endothelial adhesion molecules : intercellular adhesion molecule-1 ( ICAM-1 ) , E-selectin , and [vascular cell adhesion molecule-1] ( VCAM-1 ) , measured by both enzyme linked immunosorbent assay and flow cytometric analysis . Positive_regulation VCAM1 TNF 9015189 411920 Stimulation of IEC-4.1 cells with LPS or markedly *increased* the surface expression of both ICAM-1 and [VCAM-1] , which correlated with the increased binding of macrophages to the stimulated IEC-4.1 cells . Positive_regulation VCAM1 TNF 9022083 413240 To determine modes of retinoid action in the modulation of inflammatory responses , we explored effects of all-trans-retinoic acid ( t-RA ) on the *induced* expression of [vascular cell adhesion molecule-1] ( VCAM-1 ) , intercellular adhesion molecule-1 ( ICAM-1 ) , and E-selectin in cultured human dermal microvascular endothelial cells . Positive_regulation VCAM1 TNF 9022083 413245 Pretreatment with t-RA specifically prevented *induced* [VCAM-1] expression , but not ICAM-1 and E-selectin induction . Positive_regulation VCAM1 TNF 9022083 413248 In transcriptional activation studies , the *mediated* activation of the human [VCAM-1] promoter was inhibited after t-RA treatment , while the ICAM-1 promoter activation was unaffected , indicating that the selective inhibition of CAM expression is regulated in part at the level of gene transcription . Positive_regulation VCAM1 TNF 9029122 413583 The *induced* increases in both ICAM-1 and [VCAM-1] were dose dependent , with significant up-regulation noted at 5 microg/kg and maximal increases occurring at 10 to 25 microg/kg . Positive_regulation VCAM1 TNF 9052593 417170 We found that 17 beta-estradiol augmented the *induced* expression of endothelial leukocyte adhesion molecule-1 , intercellular adhesion molecule-1 , and [vascular cell adhesion molecule-1] by 107 , 9 , and 39 % , respectively . Positive_regulation VCAM1 TNF 9072012 419852 [VCAM-1] was constitutively expressed by Bowman 's capsule and proximal tubules and was weakly *induced* on glomerular ECs by and IL-4 in combination . Positive_regulation VCAM1 TNF 9105426 423485 Role of tyrosine kinase enzymes in and IL-1 *induced* expression of ICAM-1 and [VCAM-1] on human umbilical vein endothelial cells . Positive_regulation VCAM1 TNF 9143267 428632 Soluble p55 ( sp55 ) receptors , but not soluble p75 ( sp75 ) receptors , were found to reduce the *induced* [VCAM-1] and ICAM-1 expression in both the glioma cell line and the primary cell culture . Positive_regulation VCAM1 TNF 9209275 441016 TBP I completely abolished TNF induced IL-6 production and E-selectin induction , while it partially inhibited *induced* IL-8 production and up-regulation of ICAM-1 and [VCAM-1] . Positive_regulation VCAM1 TNF 9277478 450780 TCP succinate ( 200 microM , 24 h ) reduced *induced* [VCAM-1] and E-selectin expression from a specific mean fluorescence intensity of 151 +/- 28 to 12 +/- 4 channels and from 225 +/- 38 to 79 +/- 21 channels , respectively . Positive_regulation VCAM1 TNF 9299452 453467 PC liposomes slightly depressed *induced* [VCAM-1] expression ( 16 % vs 43-50 % for the various rHDL ) , whereas the lipid-free apolipoproteins had no effect . Positive_regulation VCAM1 TNF 9326272 457094 Inhibition of *induced* [VCAM-1] mRNA levels by forskolin was partially due to enhanced degradation of VCAM-1 message , whereas the decay rates of tumor necrosis factor-alpha induced ICAM-1 message and interleukin-1beta induced ICAM-1/VCAM-1 message were not affected by forskolin treatment . Positive_regulation VCAM1 TNF 9341756 458758 Since TNF is one of the major inducers of various adhesion molecules in human endothelial cells and their expression is known to require the activation of NF-kappa B , we examined the effect of PTPase inhibitors on the *mediated* induction of intracellular adhesion molecule (ICAM)-1 , [vascular cell adhesion molecule (VCAM)-1] and endothelial leukocyte adhesion molecule ( ELAM ) -1 . Positive_regulation VCAM1 TNF 9366433 463255 Reconstitution studies revealed that administration of 50 x 10 ( 6 ) splenocytes in SCID mice at 48 h before cytokine treatment restored the *induced* expression of [VCAM-1] to levels normally observed in wild-type mice . Positive_regulation VCAM1 TNF 9366433 463256 Reconstitution with T cell- but not B cell enriched splenocytes , also restored the *induced* expression of [VCAM-1] in SCID mice to wild-type levels . Positive_regulation VCAM1 TNF 9371591 464206 significantly *enhanced* WNV induced increases in E-selectin , P-selectin , ICAM-1 , and [VCAM-1] expression , while IFN-gamma enhanced WNV induced ICAM-1 expression . Positive_regulation VCAM1 TNF 9379054 465845 and IL-4 synergistically *increase* [vascular cell adhesion molecule-1] expression in cultured vascular smooth muscle cells . Positive_regulation VCAM1 TNF 9388244 466782 The *induction* of [vascular cell adhesion molecule-1] ( VCAM-1 ) expression by requires the activation of nuclear factor-kappaB (NF-kappaB) via a process involving the phosphorylation and degradation of its cytoplasmic inhibitor , IkappaBalpha . Positive_regulation VCAM1 TNF 9388244 466793 This correlated with a 75 % reduction in *induced* [VCAM-1] expression . Positive_regulation VCAM1 TNF 9409229 471387 In cultured human smooth muscle cells from coronary arteries and saphenous veins , and interleukin-1 beta (IL-1 beta) *induced* the expression of intercellular adhesion molecule ( ICAM-1 ) and vascular cell adhesion molecule ( [VCAM-1] ) , whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1 . Positive_regulation VCAM1 TNF 9409229 471440 The stability of *induced* ICAM-1 and [VCAM-1] expression at mRNA and protein level was not altered by cicaprost . Positive_regulation VCAM1 TNF 9421277 472480 5. The data demonstrate that apart from its antiproliferative effects on lymphocytes , MPA enhances *induced* [VCAM-1] and E-selectin surface expression on EC by selectively increasing the mRNA-stability of these cell adhesion molecules . Positive_regulation VCAM1 TNF 9448041 483776 and IL-1beta *increased* the expression of ICAM-1 , E-selectin , and [VCAM-1] , whereas IL-4 induced only that of VCAM-1 . Positive_regulation VCAM1 TNF 9488215 476502 The addition of lacidipine to human umbilical vein endothelial cells significantly reduced the expression of ICAM-1 , [VCAM-1] and E-selectin *induced* by alone or with oxidized LDL ( P < 0.001 ) . Positive_regulation VCAM1 TNF 9537837 492366 Astroglioma cell lines as well as primary human fetal astrocytes expressed low levels of [VCAM-1] constitutively , and the proinflammatory cytokines *induced* marked increases in VCAM-1 expression , particularly and IL-1beta . Positive_regulation VCAM1 TNF 9607608 508568 ICAM-1 and [VCAM-1] expression *induced* by are inhibited by a glutathione peroxidase mimic . Positive_regulation VCAM1 TNF 9607608 508569 We have used the glutathione peroxidase (GPx) mimic BXT-51072 to assess the possibility that endogenous hydroperoxides play a role in the *induced* expression of ICAM-1 and [VCAM-1] by monolayers of human endothelial cells . Positive_regulation VCAM1 TNF 9607608 508571 The GPx mimic BXT-51072 strongly inhibits the *induced* and cycloheximide-sensitive expression of ICAM-1 and [VCAM-1] . Positive_regulation VCAM1 TNF 9619632 510460 Only high-dose MP was able to down-regulate *induced* [VCAM-1] expression on endothelial cells . Positive_regulation VCAM1 TNF 9620666 510565 The NO donors , but not 8-bromo-cGMP , decreased *induced* [VCAM-1] , ICAM-1 , and E-selectin expression by 11-70 % . Positive_regulation VCAM1 TNF 9625761 511703 Interferon enhances *induced* [vascular cell adhesion molecule 1] ( CD106 ) expression in human endothelial cells by an interferon related factor 1-dependent pathway . Positive_regulation VCAM1 TNF 9625761 511704 We show that IFN-alpha and -gamma enhance *induced* [VCAM-1] mRNA transcription and protein expression in human endothelial cells . Positive_regulation VCAM1 TNF 9625761 511706 and ( d ) transfection with an expression construct encoding IRF-2 , a competitive inhibitor of IRF-1 , reduced *induced* [VCAM-1] expression . Positive_regulation VCAM1 TNF 9625761 511707 Our experiments show that IFN amplifies *induced* [VCAM-1] expression at the transcriptional level by an IRF-1 dependent pathway . Positive_regulation VCAM1 TNF 9663488 518378 Interleukin-1beta (IL-1beta) and further *induced* [VCAM-1] and ICAM-1 messenger RNA and protein expression . Positive_regulation VCAM1 TNF 9705247 525873 Mobility shift assays and Northern blot analyses further show that the supernatant from TPV infected cells inhibited induced activation of the nuclear transcription factor-kappa B ( NF-kappa B ) and transcriptional *activation* of the E-selectin , [VCAM-1] and ICAM-1 genes . Positive_regulation VCAM1 TNF 9791729 542511 A neutralizing anti-TNF monoclonal antibody ( cA2 ) was used to study the down regulation of *induced* E-selectin , [vascular cell adhesion molecule-1] ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ) on cultured human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation VCAM1 TNF 9794436 543010 Interestingly , the IL-6/sIL-6R complex inhibited *induced* [VCAM-1] gene expression but did not affect TNF-alpha induced ICAM-1 expression . Positive_regulation VCAM1 TNF 9794436 543013 A highly active fusion protein of sIL-6R and IL-6 , covalently linked by a flexible peptide , which is designated H-IL-6 , also inhibited *induced* [VCAM-1] expression . Positive_regulation VCAM1 TNF 9794436 543014 sIL-6R alone was an effective inhibitor of *induced* [VCAM-1] due to endogenous IL-6 production . Positive_regulation VCAM1 TNF 9825772 549217 [VCAM-1] expression on SK-N-SH was *induced* by IL-1alpha and TNF alpha and IFN gamma synergized with in this respect on both NB cell lines . Positive_regulation VCAM1 TNF 9832331 551715 *induced* ICAM-1 and [VCAM-1] levels in all EC were similar and significantly higher than in HVCSM ( 2.5- and 5-fold , respectively ) . Positive_regulation VCAM1 TNF 9882562 584187 Expression of membrane bound ( mb ) and soluble ( s ) forms of [vascular cell adhesion molecule-1] ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ) *induced* by has been measured by enzyme linked immunosorbent assay in cultured human brain microvessel endothelial cells . Positive_regulation VCAM1 TNF 9887050 584955 and LPS *stimulated* [vascular cell adhesion molecule (VCAM)-1] surface expression and adhesion of U-937 monocyte-like cells to HUVECs but not to HUAECs . Positive_regulation VCAM1 TNF 9887050 584956 *increased* [VCAM-1] protein and mRNA in HUVECs that was blocked by pyrrolidinedithiocarbamate . Positive_regulation VCAM1 TNF 9887050 584957 However , neither or LPS *stimulated* [VCAM-1] expression in HUAECs . Positive_regulation VCAM1 TNF 9893126 586772 ( 100 U/ml ) enhanced binding by 335 % and *up-regulated* intercellular adhesion molecule-1 ( ICAM-1 ) and [vascular cell adhesion molecule-1] ( VCAM-1 ) expression by 505 % and 179 % , respectively , as compared with MM-LDL ( 120 % and 116 % ) and LDL , which had no effect . Positive_regulation VCAM1 TNF 9925665 581363 In this study rHDL have been used to investigate whether HDL particle shape , size , apolipoprotein composition or lipid composition are important determinants of the ability of HDL to inhibit the *induced* expression of [vascular cell adhesion molecule-1] ( VCAM-1 ) in human umbilical vein endothelial cells ( HUVECs ) . Positive_regulation VCAM1 TNF 9925665 581364 ii ) Simple discoidal complexes containing only phospholipid and apoA-I ( discoidal ( A-I ) rHDL ) are sufficient to inhibit the *induced* expression of [VCAM-1] in HUVECs . Positive_regulation VCAM1 TNF 9973425 596126 We conclude that the early up-regulation of endothelial ICAM-1 and [VCAM-1] during the elicitation of contact hypersensitivity is primarily *due* to the immune dependent local release of . Positive_regulation VCAN ADAMTS1 22183742 2543329 Here we investigated the involvement of fibulin-1 in *mediated* cleavage of [versican] in vitro , and the involvement of fibulin-1 in versican cleavage in ventricular morphogenesis . Positive_regulation VCAN CD14 11545252 855515 Activation of human monocytes by [PGM] *involves* both forms of , sCD14 and mCD14 . Positive_regulation VCL CAPN8 15236355 1269709 These inhibitors also *inhibited* the translocation of full-length [vinculin] to the cytoskeleton . Positive_regulation VCL TNS1 7566975 328509 IL-3 *induced* a transient association between paxillin and [vinculin] , while in BCR/ABL transformed cells , several proteins coimmunoprecipitated with paxillin , including vinculin , p125FAK , talin and . Positive_regulation VCP EPHB2 10648884 662335 [Membrane] depolarization *induced* calcium increases activated both and p38 kinase within 5 min . Positive_regulation VCP SYT8 16713576 1564885 induces a 4-fold *increase* in the ATPase activity of wild-type [p97/VCP] ( p97/VCP ( wt ) ) , but not in mutants that showed an ERAD impairment . Positive_regulation VCP TNF 12606436 1064549 [Membrane] type-1 MMP mRNA expression in the stromal cells was *augmented* by , IL-6 , HGF , and 12-O-tetradecanoylphorbol 13-acetate . Positive_regulation VDR CYP24A1 11376120 818171 With increasing amounts of YY1 DNA transfected ( 500 ng to 2 microg ) , ligand dependent [VDR] *activation* of <24(OH)ase> transcription was steadily repressed ( maximum repression was 10-fold ) . Positive_regulation VDR CYP24A1 19667147 2119392 In this study , the effects of MART-10 and 1alpha,25 ( OH ) 2D3 on proliferation , [vitamin D receptor] *transactivation* , vitamin D-binding protein ( DBP ) binding , ( 24-OHase ) substrate hydroxylation kinetics , and induction of CYP24A1 gene expression were compared in an androgen dependent prostate cancer cell model , LNCaP . Positive_regulation VDR CYP24A1 20307664 2287540 [VDR] mRNA expression was detected in all samples and mRNA expression was *induced* by 1alpha,25 ( OH ) 2D3 in both concentrations ( but mainly with 100 nM ) . Positive_regulation VDR EPHB2 15331595 1323255 In cells utilizing RXRgamma , activation *enhances* [VDR] transcriptional activity . Positive_regulation VDR MAP2K6 17556531 1753114 Cotransfection of clone A with the VDR promoter and several mutants of MAPK kinase ( MEK ) demonstrated that the constitutively active form of significantly *increases* [VDR] promoter activation , while the catalytically inactive construct is ineffective in this regard . Positive_regulation VDR TLR7 16497887 1535292 We report here that activation of human macrophages *up-regulated* expression of the [vitamin D receptor] and the vitamin D-1-hydroxylase genes , leading to induction of the antimicrobial peptide cathelicidin and killing of intracellular Mycobacterium tuberculosis . Positive_regulation VDR TNF 15710334 1373369 [VDR] protein levels were *increased* by 0.1 nM KH 1060 , 0.1 microg/ml or their combination . Positive_regulation VDR TP63 16462763 1573924 In this study , we provide evidence that specifically *upregulates* [vitamin D Receptor (VDR)] . Positive_regulation VDR TP63 16462763 1573926 Additionally , we demonstrate that a naturally occurring p63 missense mutant , p63gamma ( R279H ) and p14 ( ARF ) , both act in a dominant negative manner to inhibit *mediated* upregulation of [VDR] . Positive_regulation VDR TP63 17716971 1801390 In this report , we examined whether p53 affects *mediated* induction of [VDR] and studied the effect of DNA damage on VDR induction in p53 null cell lines . Positive_regulation VDR TP63 17716971 1801394 Our results demonstrate that p53 itself does not induce VDR expression , nor does it affect mediated [VDR] *induction* in the cell lines tested in this study . Positive_regulation VDR TP63 17716971 1801396 In conclusion , our results indicate that [VDR] is *regulated* by and p73 and that the induction of VDR expression upon DNA damage is p73 dependent . Positive_regulation VDR TP63 19622632 2118312 Although silencing of *inhibits* [VDR] expression leading to an increase in cell migration , overexpression of p63 or VDR results in reduced cell migration as a result of increased VDR expression . Positive_regulation VEGFA ADAMTS1 16936124 1608931 These results indicate that [VEGF] significantly *induces* expression in endothelial cells in a PKC dependent fashion . Positive_regulation VEGFA ADAMTS1 18272597 1891229 Renal ischemia reperfusion inhibits [VEGF] expression and *induces* , a novel VEGF inhibitor . Positive_regulation VEGFA ANGPT1 12967476 1138877 In this system , which mimics angiogenesis in vivo , fibroblasts secrete a basal level of [vascular endothelial growth factor] ( VEGF ) , and *stimulated* tube formation . Positive_regulation VEGFA ANGPT1 15746084 1409703 Tie2 was expressed in the lymphatic endothelial cells and stimulation of these cells *resulted* in up-regulation of [vascular endothelial growth factor] receptor 3 ( VEGFR-3 ) . Positive_regulation VEGFA ANGPT1 16949254 1682500 Addition of exogenous VEGF-A restored cell spreading and protrusion , leading to Ang1 induced capillary morphogenesis of Src siRNA treated HUVECs , suggesting that *induced* [VEGF-A] secretion through Src was required for capillary morphogenesis . Positive_regulation VEGFA ANGPT1 17502485 1739951 prevented regression of the TGFbeta1 induced CLS , an effect that was blocked by angiopoietin 2 (Ang2) , but *required* the continuous presence of [VEGF] . Positive_regulation VEGFA ANGPT1 22596210 2643464 IL-6 not only enhances [VEGF] expression but also *inhibits* Ang-1 signalling by directly down regulating expression and up-regulating Ang-2 , an antagonist of Ang-1 . Positive_regulation VEGFA ANGPT1 9774272 539632 Targeted gene inactivation studies in mice have shown that [VEGF] is necessary for the early stages of vascular development and that is *required* for the later stages of vascular remodeling . Positive_regulation VEGFA CCND1 19114984 2031788 PTK/ZK also induced cell cycle arrest , accompanied by increasing the expression of p27 ( Kip1 ) and downregulation of and cyclin E. PTK/ZK significantly *inhibited* [vascular endothelial growth factor] ( VEGF ) expression , as well as VEGF simulated cell proliferation and phosphorylation of Akt in activated HSCs . Positive_regulation VEGFA CD14 10084996 599277 LPS augmented the [VEGF] production in HPC cultures in the *presence* of recombinant human soluble ( sCD14 ) . Positive_regulation VEGFA CHI3L1 21357475 2426477 mAY also abolished induced *activation* of the membrane receptor [VEGF] receptor 2 ( Flk-1/KDR ) and intracellular signaling mitogen activated protein (MAP) kinase extracellular signal regulated kinase ( Erk ) 1 and Erk 2 . Positive_regulation VEGFA CTGF 11018037 752823 [Vascular endothelial growth factor] *induces* expression of via KDR , Flt1 , and phosphatidylinositol 3-kinase-akt dependent pathways in retinal vascular cells . Positive_regulation VEGFA CTGF 15258030 1272375 It has a role in the pathogenesis of diabetic nephropathy and possibly in diabetic retinopathy ( DR ) : in cultured retinal vascular cells is *induced* by [VEGF-A] . Positive_regulation VEGFA CTGF 17303801 1733693 Nevertheless , *promoted* [vascular endothelial growth factor] ( VEGF ) gene expression by hyalocytes and BRPEs . Positive_regulation VEGFA CTGF 18835464 2012821 CCN family <2/connective tissue growth factor> ( CCN2/CTGF ) *regulates* the expression of [Vegf] through Hif-1alpha expression in a chondrocytic cell line , HCS-2/8 , under hypoxic condition . Positive_regulation VEGFA CTGF 18835464 2012879 On the other hand , the phenotype of Ccn2 mutant growth plates , which exhibit decreased expression of VEGF in the hypertrophic zone , indicates that [Vegf] expression is *dependent* on expression as well . Positive_regulation VEGFA CTGF 18835464 2012880 Therefore , we investigated the molecular mechanisms underlying the *induction* of [VEGF] by using a human chondrocytic cell line , HCS-2/8 . Positive_regulation VEGFA CTGF 20039857 2339323 These results suggest that the diabetes mediated increase in *upregulates* [VEGF] and TGF-ß ( 2 ) expression and induces apoptosis in the retina . Positive_regulation VEGFA DAPK1 24337450 2895130 In the present study , we investigated whether overexpression may *mediate* vascular endothelial growth factor ( [VEGF] ) /hypoxia-inducible factor-1a (HIF-1a) expression and angiogenic activity in the human carcinoma cell model system . Positive_regulation VEGFA EDN2 20176726 2228925 *induced* in GCs changes that characterize the developing CL : cell proliferation as well as up-regulation of [vascular endothelial growth factor] and cyclooxygenase-2 ( mRNA and protein levels ) . Positive_regulation VEGFA EPHB2 10671553 666899 kinase inhibition *diminished* [VEGF-] , FGF- , and EGF promoted thymidine incorporation into DNA . Positive_regulation VEGFA EPHB2 11741977 921980 While investigating the upstream signaling pathways , we found that ERK1/2 MAPK is activated and translocates to the nucleus to activate Elk-1 , and inhibition of the activation of by specific inhibitors of MEK1 *blocks* the up-regulation of [VEGF] by low pH . Positive_regulation VEGFA EPHB2 12440226 1016960 These results suggest that EGCG *inhibits* [VEGF] production by inhibiting both the constitutive activation of Stat3 and NF-kappa B , but not extracellular-signal regulated kinase ( ) or Akt , in these cells . Positive_regulation VEGFA EPHB2 12680875 1077308 Since the intracellular signalling of SDF-1 induced neovascularization remains unclear , we studied in human umbilical arterial endothelial cells ( HUAEC ) the influence of SDF-1alpha on induction of the genes of early growth response-1 (Egr-1) and [VEGF] , as well as the *activation* of 1/2 , which are all known to be involved in endothelial cell proliferation . Positive_regulation VEGFA EPHB2 15541367 1336923 [VEGF-KDR] stimulation did not *induce* phosphorylation in human PKCdelta-knockdown HEK293T cells , but co-expression of rat PKCdelta-GFP recovered the ERK phosphorylation . Positive_regulation VEGFA EPHB2 16164642 1456357 and VEGF stimulated eNOS phosphorylation on Ser1177 was prevented by PD098059 , an upstream inhibitor of ERK , demonstrating that was *involved* in [VEGF] regulation of eNOS . Positive_regulation VEGFA EPHB2 16530725 1536434 Inhibitors of either extracellular signal regulating kinase ( ERK ) or phosphatidylinositol 3-kinase (PI3K) partly reversed the thrombin induced cytokine expression , suggesting that both and PI3K kinase pathways may be *involved* in IL-8 and [VEGF] expression . Positive_regulation VEGFA EPHB2 17027148 1700271 To determine the basis of these observations , we examined the expression of [VEGF] and *activation* of JNK and in A549 cells exposed to LGD1069 . Positive_regulation VEGFA EPHB2 17627770 1816042 Selective inhibitors of p38 MAPK ( SB203580 ) , ( PD98059 ) , and JNK ( SP600125 ) could differentially *inhibit* the production of EGF , [VEGF] and CCL2 , thereby suggesting a role for MAPKs in IL-31 functions . Positive_regulation VEGFA EPHB2 18852899 1977128 Thus , inhibition of either or Sp1 *suppressed* M-CSF induced [VEGF] at the mRNA and protein level . Positive_regulation VEGFA EPHB2 19098317 2047579 *Role* of PI3K/Akt and in mediating hypoxia induced expression of HIF-1alpha and [VEGF] in laser induced rat choroidal neovascularization . Positive_regulation VEGFA EPHB2 19129286 2047891 While inhibitor *reduced* [VEGF] secretion only in NHBE , a PKC inhibitor significantly decreased VEGF secretion in both NHBE and SAEC . Positive_regulation VEGFA EPHB2 19385062 2069346 The exchange protein directly activated by cAMP ( Epac ) activator , 8CPT-2Me-cAMP , promoted the Akt/eNOS/NO pathway and phosphorylation , but did not *induce* CREB phosphorylation and [VEGF] expression . Positive_regulation VEGFA EPHB2 19874715 2156800 Furthermore , a pharmacological inhibitory study revealed that G ( alpha i/o ) -mediated phospholipase C , Akt , , and p38 MAPK signaling are *involved* in this S1P induced expression of [VEGF] . Positive_regulation VEGFA EPHB2 20160089 2215007 SP-induced [VEGF] production *involves* calcium dependent PKC isoforms , as well as the and JNK MAPKs . Positive_regulation VEGFA EPHB2 20338920 2260570 Ephrin B2/EphB4 pathway in hepatic stellate cells stimulates *dependent* [VEGF] production and sinusoidal endothelial cell recruitment . Positive_regulation VEGFA EPHB2 20395410 2287868 [VEGF] *induced* and AKT phosphorylation ( indicative of differentiation ) , while inhibiting phosphorylation of STAT3 ( indicative of ` stemness ' ) . Positive_regulation VEGFA EPHB2 20861185 2337054 Notably , modulation of [VEGF] expression by DLC1 was *dependent* on epidermal growth factor kinase-hypoxia-inducible factor 1 signaling but on RhoA pathways . Positive_regulation VEGFA EPHB2 21120482 2469498 The PI3 K or inhibitors also *attenuated* expression of [VEGF] and MMP-9 . Positive_regulation VEGFA EPHB2 21544242 2424330 The AKT and inhibitors , LY294002 and U0126 , *suppressed* HIF-1a and [VEGF] expression and angiogenesis . Positive_regulation VEGFA EPHB2 21984483 2526010 Furthermore , cadmium induced [vascular endothelial growth factor] expression and transcriptional *activation* through ROS , , and AKT pathways . Positive_regulation VEGFA EPHB2 22926523 2818142 In conclusion , our findings provide evidence that GAB2 is a novel regulator of tumor angiogenesis in NRAS-driven melanoma through regulation of HIF-1a and [VEGF] expressions *mediated* by signaling . Positive_regulation VEGFA EPHB2 23167467 2700265 Our results suggest that EMD stimulates VEGF production partially via TGF-ß1 and FGF-2 in human gingival fibroblasts and that EMD induced [VEGF] production is *regulated* by , p38 MAPK , and PI3K/Akt pathways . Positive_regulation VEGFA EPHB2 23367565 2712934 In addition , [VEGF] induction by DENV2 was significantly *impaired* by knockdown of TLR3 and interferon-beta promoter stimulator 1 ( IPS-1 ) , or by inhibition of , JNK or NF-kappaB . Positive_regulation VEGFA EPHB2 23428975 2744226 Furthermore , Cav-1 increased proMMP-1 and [VEGF] secretion in HGFs , and the VEGF secretion was statistically *suppressed* by JNK inhibitor SP600125 , but not inhibitor PD98059 . Positive_regulation VEGFA EPHB2 23570600 2768000 PGE1 time-dependently induced both phosphorylation of ERK and p38 in HUVEC , whereas inhibitor , PD98059 , or p38 inhibitor , SB203580 , *blocked* PGE1 induced [VEGF] expression of HUVEC , resulting in dramatically suppression of HUVEC proliferation and migration compared with PGE1 treatment alone ( 60 % and 55 % by PD98059 , 62 % and 51 % by SB203580 , respectively ) ; Positive_regulation VEGFA EPHB2 24220315 2916539 [VEGF] and ICPP *induced* phosphorylation in the myocardium . Positive_regulation VEGFA EPHB2 24788652 2937243 Release of VEGF induced by Gal-8 was partially prevented by COX-1 , PKC , p38 and Src kinases inhibitors , whereas Gal-1 induced [VEGF] secretion was *inhibited* by PKC and blockade , and Gal-3 triggered VEGF release selectively through a PKC dependent pathway . Positive_regulation VEGFA F2R 11956584 931208 The secretion of [VEGF] protein in glioma cells was *stimulated* by the agonist peptide and the induction of VEGF was significantly blocked by the thrombin inhibitor hirudin , indicating that the up-regulation of VEGF was mediated by the thrombin/thrombin receptor pathway . Positive_regulation VEGFA F2R 12554695 1051500 Specific inhibitors of protein kinase C ( PKC ) , Src , and phosphatidylinositol 3-kinase (PI3K) inhibit *induced* [VEGF] expression , suggesting the participation of these kinases in the process . Positive_regulation VEGFA F2R 21711961 2447151 Thrombin and agonist peptide significantly *stimulated* [VEGF] secretion from cultured human airway epithelial cells . Positive_regulation VEGFA F2R 24127927 2853263 Aspirin use also decreased *mediated* release of TSP-1 and [VEGF] from platelets . Positive_regulation VEGFA F3 8706889 373513 expression on the surface of endothelial cells can be *induced* by tumor necrosis factor (TNF) and [vascular endothelial growth factor] ( VEGF ) in a synergistic manner . Positive_regulation VEGFA F3 9531578 496911 *dependent* [vascular endothelial growth factor] production by human fibroblasts in response to activated factor VII . Positive_regulation VEGFA FAS 15669079 1382138 Considering that Her-2/neu overexpression correlates with increased expression of the hypoxia inducible factor-1alpha ( HIF-1alpha ) , which , in a mitogen activated protein kinase (MAPK) dependent manner , plays a key role in the expression of several genes including cytokines such as vascular endothelial growth factor ( VEGF ) , we hypothesized that blockade should *result* in a concomitant down-regulation of [VEGF] . Positive_regulation VEGFA FAS 17239146 1690494 *mediated* upregulation of [vascular endothelial growth factor] and monocyte chemoattractant protein-1 expression in cultured dermal fibroblasts : role in the inflammatory response . Positive_regulation VEGFA FOXO1 16077930 1442444 Overall , our data suggest that a high level of MMP-2 protein and [VEGF/VEGFR] expression may contribute to the metastatic phenotype of ARMS cells and that exogenously induced expression *increases* MMP-2 secretion and invasive capability of RMS cells . Positive_regulation VEGFA GLP1R 20621380 2310035 In vitro , *induced* increases in [VEGF] and IGF-1 mRNA expression were blunted in cells with PDX-1 siRNA . Positive_regulation VEGFA GPR115 21559457 2429588 Here we report that the KSHV ( vGPCR ) *upregulates* [VEGF] in KS through an intricate paracrine mechanism . Positive_regulation VEGFA GPR132 21559457 2429577 Here we report that the KSHV ( vGPCR ) *upregulates* [VEGF] in KS through an intricate paracrine mechanism . Positive_regulation VEGFA GPR87 21559457 2429657 Here we report that the KSHV ( vGPCR ) *upregulates* [VEGF] in KS through an intricate paracrine mechanism . Positive_regulation VEGFA HBEGF 15289334 1278389 We demonstrate here that in EJ human bladder cancer cells containing a tetracycline-regulatable s-HB-EGF or pro-HB-EGF expression system , expression *increased* their transformed phenotypes , including growth rate , colony forming ability , and activation of cyclin D1 promoter , as well as induction of [vascular endothelial growth factor] in vitro . Positive_regulation VEGFA HBEGF 15988409 1429317 In cultured Müller cells , *stimulated* both proliferation and chemotaxis , and the secretion of [VEGF] , via activation of the extracellular signal regulated kinases 1 and 2 and of the phosphatidylinositol-3 kinase . Positive_regulation VEGFA HBEGF 17050278 1636084 Exogenous *stimulates* proliferation and migration of RPE cells and the gene and protein expression of the vascular endothelial growth factor ( [VEGF] ) . Positive_regulation VEGFA HBEGF 18852147 1977068 The reduction of expression *attenuated* the chemotactic invasive ability and the expression of matrix metalloprotease (MMP)-2 and [vascular endothelial growth factor] ( VEGF ) , leading to the inhibition of cell invasion and angiogenesis . Positive_regulation VEGFA HBEGF 19559571 2110492 *induced* [VEGF] production and eNOS activation depend on both PI3 kinase and MAP kinase in HaCaT cells . Positive_regulation VEGFA HBEGF 19559571 2110494 Although endothelial nitric oxide synthase (eNOS) and vascular endothelial growth factor ( VEGF ) appear to be involved in mitogenesis and chemotaxis in epidermal keratinocytes , the activation of eNOS and [VEGF] production *induced* by and its signaling mechanism remains undefined . Positive_regulation VEGFA HBEGF 19559571 2110496 We examined possible signal transduction pathways by which *leads* to eNOS activation and [VEGF] production in human epidermal keratinocyte cell line ( HaCaT cells ) . Positive_regulation VEGFA HBEGF 19559571 2110517 *increased* [VEGF] production . Positive_regulation VEGFA HBEGF 19559571 2110518 The *induced* [VEGF] production was blocked by U0126 and LY294002 . Positive_regulation VEGFA HBEGF 21854110 2496051 Effect of and amphiregulin on the MAP kinase *induced* production of [vascular endothelial growth factor] by human granulosa cells . Positive_regulation VEGFA HBEGF 21854110 2496055 Our aim is to clarify the regulation of [vascular endothelial growth factor] ( VEGF ) production *induced* by ( HB-EGF ) and amphiregulin (AR) in a human granulosa cell line , KGN . Positive_regulation VEGFA HBEGF 21854110 2496057 [VEGF] production was significantly *increased* by or AR alone in a dose dependent manner , whereas it was decreased by AG1478 or U0126 . Positive_regulation VEGFA HBEGF 21854110 2496058 The results suggested that [VEGF] is *induced* by and AR through mechanisms involving MAP kinase . Positive_regulation VEGFA HBEGF 23251664 2708956 We also found that Y-142 inhibited *induced* cancer cell proliferation , endothelial cell proliferation , tube formation , and [VEGF] production more effectively than cetuximab and CRM197 and that Y-142 was superior to bevacizumab in the inhibition of HB-EGF induced tube formation . Positive_regulation VEGFA HBEGF 23443317 2781129 We show that *regulates* the expression of [VEGFA] or ANGPTL4 via transcriptional regulation of hypoxia-inducible factor-1a and NF-?B . Positive_regulation VEGFA ID1 15494533 1321911 [Vascular endothelial growth factor] ( VEGF ) and TGFbeta *induced* the expression of and Id3 in HUVECs . Positive_regulation VEGFA ID1 15905202 1451790 Using prostate cancer cells ectopically transfected with the Id-1 gene , we found that upregulation of *induced* [VEGF] secretion through activation of the VEGF gene transcription . Positive_regulation VEGFA ID1 15905202 1451791 Downregulation of , however , *led* to the suppression of [VEGF] secretion and its gene promoter activity . Positive_regulation VEGFA ID1 17145808 1653876 *induced* transcriptional activation of [VEGF] by stabilizing hypoxia-inducible factor-1alpha protein . Positive_regulation VEGFA ID1 17145808 1653877 Down-regulation of by antisense approach *led* to suppression of hypoxia-inducible factor-1alpha mediated [VEGF] production . Positive_regulation VEGFA ID1 17426247 1723965 Here , we show the cross talk between Id-1 and hypoxia-inducible factor-1alpha ( HIF-1alpha ) , that *induces* [VEGF] by enhancing the stability and activity of HIF-1alpha in human endothelial and breast cancer cells . Positive_regulation VEGFA ID1 17426247 1723966 Although both the transcript and proteins levels of [VEGF] were *induced* by , only the protein expression of HIF-1alpha was induced without transcriptional changes in both human umbilical endothelial cells and MCF7 breast cancer cells . Positive_regulation VEGFA ID1 21880603 2486785 Both [VEGF] and BMP2 could *induce* the overexpression of gene which significantly promoted tube formation in vitro and increase the amount of blood vessels in the Ad-BMP2-BMSC + Ad-VEGF-EPC group after implantation . Positive_regulation VEGFA IL1B 10024512 590876 The inflammatory cytokine *mediated* a moderate increase in [VEGF] expression after 24 h and had no influence on FLT-1 expression . Positive_regulation VEGFA IL1B 10408390 629818 We investigated *induction* of [VEGF] expression in colon cancer cells and the mechanism by which this occurs . Positive_regulation VEGFA IL1B 10408390 629819 *induction* of [VEGF] was also confirmed at the protein level . Positive_regulation VEGFA IL1B 10408390 629820 To examine the mechanism for [VEGF] *induction* by , we transiently transfected VEGF promoter-reporter constructs into HT29 cells . Positive_regulation VEGFA IL1B 10408390 629821 These findings suggest that *regulates* [VEGF] expression in human colon cancer cells by increasing transcription of the VEGF gene . Positive_regulation VEGFA IL1B 10732316 678309 Periovulatory and *dependent* up-regulation of intraovarian [vascular endothelial growth factor] ( VEGF ) in the rat : potential role for VEGF in the promotion of periovulatory angiogenesis and vascular permeability . Positive_regulation VEGFA IL1B 10799861 691368 Stimulation of FLS with TNF-alpha , , and TGF-beta *increased* [VEGF] production by 1.6- , 2.0- , and 5.2-fold , respectively , and displayed an additive effect on the production of VEGF by CD40L . Positive_regulation VEGFA IL1B 10886548 709839 Hypoxia and *stimulate* [vascular endothelial growth factor] production in human proximal tubular cells . Positive_regulation VEGFA IL1B 11023800 762615 , expressed by the blastocyst , *induces* [vascular endothelial growth factor] ( VEGF ) which , in turn , promotes angiogenesis and integrin expression in endometrial cells . Positive_regulation VEGFA IL1B 11040101 741896 *Induction* of [VEGF] gene transcription by is mediated through stress activated MAP kinases and Sp1 sites in cardiac myocytes . Positive_regulation VEGFA IL1B 11040101 741912 Transient transfection assays showed that *increases* the transcription from the [VEGF] promoter . Positive_regulation VEGFA IL1B 11040101 741913 Together , these results indicate that *induces* [VEGF] gene expression at both transcriptional and post-transcriptional levels , and IL-1 beta evokes p38 MAPK and JNK signalings , which in turn stimulate the transcription of the VEGF gene through Sp1 binding sites . Positive_regulation VEGFA IL1B 11423727 831031 In contrast , TBF-beta and *caused* an increase in [VEGF] production . Positive_regulation VEGFA IL1B 11730812 885029 In rat , VSMC *induced* NO generation and enhanced [VEGF] synthesis . Positive_regulation VEGFA IL1B 11730812 885030 7-Kchol decreased rat iNOS promoter activity , iNOS expression and NO generation , but it did not impair *induced* [VEGF] synthesis . Positive_regulation VEGFA IL1B 11806247 892601 We previously demonstrated that *leads* to induction of [vascular endothelial growth factor] ( VEGF ) in human colon carcinoma cells . Positive_regulation VEGFA IL1B 11806247 892604 These data demonstrate that may *induce* [VEGF] in hVSMCs , and suggest that this paracrine signaling pathway , may prevent , in part , apoptosis of ECs . Positive_regulation VEGFA IL1B 12084593 958797 In vitro , atorvastatin decreased both the basal and the *induced* [VEGF] release in HCASMC . Positive_regulation VEGFA IL1B 12384916 999420 [VEGF] production was potently *induced* by TGFbeta , and to a lesser extent by and TNF , and was further augmented by hypoxia . Positive_regulation VEGFA IL1B 12789234 1097431 also *increased* [VEGF] production , but this was not affected by IFN-gamma ( P > .05 ) . Positive_regulation VEGFA IL1B 12824917 1104403 Exogenous *enhanced* expression of various cytokines ( IL-6 , IL-8 , and [vascular endothelial growth factor] ( VEGF ) ) and intracellular adhesion molecule-1 ( ICAM-1 ) by A549 , PC14 , RERF-LC-AI , and SBC-3 cells expressing IL-1 receptors . Positive_regulation VEGFA IL1B 12958148 1158159 We find that up-regulated HIF-1alpha protein under normoxia and *activated* the HIF-1-responsive gene [vascular endothelial growth factor] ( VEGF ) via a pathway dependent on nuclear factor kappaB (NFkB) . Positive_regulation VEGFA IL1B 14960485 1242919 Meanwhile , also *induced* the secretion of [VEGF] in normal human cytotrophoblast cells . Positive_regulation VEGFA IL1B 14960485 1242921 These data indicate that , in normal human cytotrophoblast cells , *induces* HIF- 1 alpha mediated [VEGF] secretion and that IL-1 beta stimulated ERK1/2 activation may be involved in this process . Positive_regulation VEGFA IL1B 14991903 1215654 Furthermore , [VEGF] *induced* , IL-6 , TNF-alpha , and nitric oxide expression to a small extent and stimulated the proliferation of immortalized chondrocytes . Positive_regulation VEGFA IL1B 15007259 1217684 Additionally , this treatment suppressed basal and *stimulated* synthesis of [VEGF] in HMEC-1 . Positive_regulation VEGFA IL1B 15081307 1234106 We have reported that *upregulates* cardiac expression of vascular endothelial growth factor ( [VEGF] ) and VEGF receptor-2 (VEGFR-2) , raising the possibility that IL-1 beta plays an important role in VEGF mediated neovascularization . Positive_regulation VEGFA IL1B 15126358 1244842 We previously demonstrated that *regulates* [VEGF] expression in tumor cells . Positive_regulation VEGFA IL1B 15325633 1287165 IL-17 , and TNF-alpha *stimulate* [VEGF] production by dedifferentiated chondrocytes . Positive_regulation VEGFA IL1B 15665043 1402403 Oncostatin M (OSM) , but not other IL-6 family cytokines , increased [VEGF] release , and *enhanced* OSM induced VEGF release . Positive_regulation VEGFA IL1B 15665043 1402407 did not augment the effects of OSM on VEGF promoter activity but did *augment* OSM induced [VEGF] mRNA expression and mRNA stability . Positive_regulation VEGFA IL1B 15665043 1402411 In contrast , inhibitors of MAPK pathway had no effect on OSM or OSM plus *induced* [VEGF] release . Positive_regulation VEGFA IL1B 15665043 1402415 Consistent with the increase in IL-1R1 expression , OSM markedly augmented *induced* [VEGF] , MCP-1 , and IL-6 release . Positive_regulation VEGFA IL1B 15862289 1400881 Here , we report that [vascular endothelial growth factor] ( VEGF ) -A secretion by human airway smooth muscle cells was *increased* by and transforming growth factor beta ( TGFbeta ) . Positive_regulation VEGFA IL1B 15862289 1400884 In conclusion , *increases* [VEGF-A] secretion by COX-2 derived PGE ( 2 ) production whereas TGFbeta uses COX independent pathways . Positive_regulation VEGFA IL1B 15943987 1415951 [VEGF] secretion in OVCA cells was also *increased* by ( 514 +/- 105 pg/10 ( 5 ) cells ; Positive_regulation VEGFA IL1B 16006751 1441348 We investigated the expression of [VEGF] *induced* by in five colon cancer cell lines and the possible involvement of IL-1 RA . Positive_regulation VEGFA IL1B 16006751 1441349 *induced* [VEGF] secretion with a 19-fold increase in Caco-2 cells . Positive_regulation VEGFA IL1B 16006751 1441351 IL-1 RA inhibited *induced* [VEGF] secretion by 87 % . Positive_regulation VEGFA IL1B 16006751 1441352 Our data suggest that *induces* [VEGF] expression and IL-1 RA acts as the competitive inhibitor , and that the IL-1 RA/IL-1beta ratio is significant for VEGF expression in the microenvironment of colorectal cancer tissue . Positive_regulation VEGFA IL1B 16006751 1441353 We conclude that *induces* [VEGF] secretion in a certain population of colorectal cancer patients , and that IL-1 RA is the potential therapeutic agent for antiangiogenic therapy in colorectal cancer patients . Positive_regulation VEGFA IL1B 16049703 1525198 Triamcinolone acetonide suppresses *mediated* increase in [vascular endothelial growth factor] expression in cultured rat Müller cells . Positive_regulation VEGFA IL1B 16049703 1525199 Stimulation of Müller cells by either or hypoxia *induced* [VEGF] mRNA expression . Positive_regulation VEGFA IL1B 16049703 1525200 Pretreatment of cells with TA efficiently suppressed [VEGF] *induction* by but not by hypoxia . Positive_regulation VEGFA IL1B 16049703 1525201 RNA decay assays and promoter analysis of the VEGF gene indicated that TA inhibited the *mediated* increase in [VEGF] gene expression at the transcriptional level . Positive_regulation VEGFA IL1B 16049703 1525202 TA suppressed [VEGF] expression *induced* by in Müller cells at the transcriptional level . Positive_regulation VEGFA IL1B 16095117 1443666 [VEGF] release from chondrocytes in the *presence* of , TGFbeta and IL-10 was detected by immunoassay . Positive_regulation VEGFA IL1B 16311048 1553743 IL-17 , TNF-alpha and *increased* [VEGF] secretion by synovial fibroblasts from OA patients . Positive_regulation VEGFA IL1B 16311048 1553745 IL-17 and also *increased* [VEGF] secretion in RA and FP . Positive_regulation VEGFA IL1B 16565972 1549860 *regulated* [VEGF-A] and Ang-1 expressions in a dose dependent manner . Positive_regulation VEGFA IL1B 16770323 1585526 3. In human keratinocyte cultures ( HaCaT cells ) , ginsenoside Rb1 ( 100 fg ml(-1) to 1 ng ml(-1) ) enhanced [VEGF] production *induced* by and expression of hypoxia-inducible factor (HIF)-1alpha . Positive_regulation VEGFA IL1B 16964394 1611534 significantly *stimulated* [VEGF] secretion in these glioma cells . Positive_regulation VEGFA IL1B 17015745 1629869 Suggesting functional significance , we found that expression of in the brain *induced* astrocytic expression of HIF-1alpha , [VEGF-A] , and BBB permeability . Positive_regulation VEGFA IL1B 17035941 1649227 *induces* [VEGF] , independently of PGE2 induction , mainly through the PI3-K/mTOR pathway in renal mesangial cells . Positive_regulation VEGFA IL1B 17035941 1649232 Indomethacin exerted a nonsignificant effect on *induced* [VEGF] , and exogenously added PGE2 exhibited a nonsignificant stimulatory effect on VEGF formation . Positive_regulation VEGFA IL1B 17035941 1649235 SB 203580 , a p38 mitogen activated protein kinase inhibitor , weakly inhibited the *induction* of [VEGF] by in a concentration dependent manner , whereas LY 294002 , a phosphoinoside 3-kinase (PI3-K) inhibitor , and rapamycin , a mammalian target of rapamycin (mTOR) inhibitor , strongly inhibited both IL-1beta- and tumor necrosis factor-alpha induced VEGF formation in a concentration dependent manner . Positive_regulation VEGFA IL1B 17071533 1637654 *regulates* [vascular endothelial growth factor] and soluble fms-like tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts . Positive_regulation VEGFA IL1B 17071533 1637660 The secretion of [VEGF] and sFlt-1 by cultured OECs and OSFs in *response* to and IL-1 receptor antagonist (IL-1RA) was measured using an enzyme linked immunosorbent assay . Positive_regulation VEGFA IL1B 17071533 1637664 *induced* production of [VEGF] and sFlt-1 by these cells was significantly inhibited by the addition of IL-1RA . Positive_regulation VEGFA IL1B 17100776 1644820 The IL-8 and [VEGF] production induced by TWEAK was *augmented* synergistically by simultaneous stimulation with transforming growth factor (TGF)-beta1 or . Positive_regulation VEGFA IL1B 17237427 1690104 Deletion of SAF-1 binding elements from the VEGF promoter as well as knockdown of endogenous SAF-1 markedly inhibited and TGF-beta mediated *induction* of [VEGF] expression in chondrocyte cells . Positive_regulation VEGFA IL1B 17690185 1788395 Here , we show that dexamethasone inhibits *induced* neovascularization and the expression of the angiogenesis related factors , [vascular endothelial growth factor-A] , KC , and prostaglandin E ( 2 ) in the mouse cornea 2 days after IL-1beta implantation . Positive_regulation VEGFA IL1B 17690185 1788397 Furthermore , dexamethasone inhibited *induced* expression of [vascular endothelial growth factor-A] , KC , and prostaglandin E ( 2 ) , and signaling of nuclear factor (NF)-kappaB in corneal fibroblasts in vitro . Positive_regulation VEGFA IL1B 17920534 1804176 Bucillamine mechanism inhibiting *induced* [VEGF] production from fibroblast-like synoviocytes . Positive_regulation VEGFA IL1B 17920534 1804177 We investigated the bucillamine ( Buc ) mechanism inhibiting *induced* [vascular endothelial growth factor] ( VEGF ) production from human fibroblast-like synoviocytes ( HFLS ) which derived from the inflamed synovium of an RA patient using SA981 , its active metabolite . Positive_regulation VEGFA IL1B 17920534 1804178 While SA981 partially inhibited *induced* [VEGF] production at concentrations of 10 to 100 microM ( 10.1 % and 14.2 % inhibition of total VEGF production under IL-1beta coexistence condition , respectively ) , it failed to inhibit IL-1beta induced IL-6 production at the same concentrations . Positive_regulation VEGFA IL1B 19458323 2136075 Moreover , IL-1 alpha and *enhanced* [VEGF] and iNOS expression by murine peritoneal macrophages . Positive_regulation VEGFA IL1B 19474288 2102344 [Vascular endothelial growth factor] expression in cultured DSCs increased in *response* to stimulation with ( IL-1 beta ; 0.01-10 ng/mL ) -- but not tumor necrosis factor alpha ( TNF-alpha ; 1 ng/mL ) -- in a concentration dependent fashion irrespective of the hormonal milieu . Positive_regulation VEGFA IL1B 19878566 2160819 We report that VEGF and IL-1beta-stimulate endothelial permeability via Src dependent pathway by increasing the Src phosphorylation and Ag-NP block the [VEGF-and] *induced* Src phosphorylation at Y419 . Positive_regulation VEGFA IL1B 7814392 292624 *Induction* of [vascular endothelial growth factor] gene expression by in rat aortic smooth muscle cells . Positive_regulation VEGFA IL1B 7814392 292625 To determine whether , which is present in atherosclerotic lesions , *induces* [VEGF] gene expression in vascular smooth muscle cells , we performed RNA blot analysis on rat aortic smooth muscle cells ( RASMC ) with a rat VEGF cDNA probe . Positive_regulation VEGFA IL1B 7814392 292626 *increased* [VEGF] mRNA levels in RASMC in a time- and dose dependent manner . Positive_regulation VEGFA IL1B 7814392 292627 As little as 0.1 ng/ml *increased* [VEGF] mRNA levels by 2-fold and 10 ng/ml IL-1 beta increased VEGF mRNA by 4-fold . Positive_regulation VEGFA IL1B 7814392 292628 We also measured the half-life of VEGF mRNA and performed nuclear run-on experiments before and after addition of IL-1 beta to see if *increased* [VEGF] mRNA levels by stabilizing the mRNA or by increasing its rate of transcription . Positive_regulation VEGFA IL1B 7814392 292629 The normal , 2-h half-life of VEGF mRNA in RASMC was lengthened to 3.2 h ( 60 % ) by IL-1 beta , and *increased* the rate of [VEGF] gene transcription by 2.1-fold . Positive_regulation VEGFA IL1B 7814392 292630 In immunoblot experiments with an antibody specific for VEGF , we found that *increased* [VEGF] protein levels in RASMC by 3.3-fold . Positive_regulation VEGFA IL1B 7814392 292631 Together these data indicate that *induces* [VEGF] gene expression in smooth muscle cells . Positive_regulation VEGFA IL1B 7814392 292633 This *induced* expression of [VEGF] may accelerate the progression of atherosclerotic lesions by promoting the development of new blood vessels . Positive_regulation VEGFA IL1B 9228120 443544 [VEGF] secretion was further *inducible* by both hypoxia and and these increases were additive . Positive_regulation VEGFA MAOA 24865426 2945510 Knockdown and overexpression of MAOA in human PCa cell lines indicated that *induces* EMT through activation of [VEGF] and its coreceptor neuropilin-1 . Positive_regulation VEGFA MAP2K6 11234901 789752 Basal and tumor necrosis factor-alpha-inducible phosphorylation of ERK1/2 and secretion of IL-8 and [VEGF] could be specifically *inhibited* by a inhibitor , U0126 . Positive_regulation VEGFA MAP2K6 15319299 1341730 Furthermore , the stimulatory action of nicotine on cancer cell growth and angiogenic factor [VEGF] production was *suppressed* by inhibitors of ( U0126 ) and COX-2 ( SC-236 ) . Positive_regulation VEGFA MAP2K6 16682956 1624658 Notably , in both FAK inhibited 4T1 and Src transformed FAK-null cells , constitutively activated ( CA ) 1 ( MEK1 ) *restored* [VEGF] production and CA-MEK1 or added VEGF rescued tumor growth and angiogenesis . Positive_regulation VEGFA MAP2K6 19098317 2047588 *Role* of PI3K/Akt and in mediating hypoxia induced expression of HIF-1alpha and [VEGF] in laser induced rat choroidal neovascularization . Positive_regulation VEGFA MAP2K6 19098317 2047657 PI3K inhibitor ( Ly294002 ) significantly decreased pAkt activity and HIF-1alpha and VEGF expression in vivo and in vitro , whereas inhibitor ( PD98059 ) *reduced* ERK phosphorylation and the expression of [VEGF] but had no effect on HIF-1alpha . Positive_regulation VEGFA MAP2K6 19181503 2071591 On the other hand , we found that adenoviral constitutive ( Ad-CA-MEK ) significantly *increased* MMP-9 and [VEGF] expression . Positive_regulation VEGFA MAP2K6 22707147 2633916 Moreover , [VEGF] ( 165 ) *induced* phosphorylation of VEGFR-2 , PLC-?1 , PKC-a , , and p44/42 MAPK ( ERK1/2 ) in a time dependent manner . Positive_regulation VEGFA MAP2K6 22926523 2818148 In conclusion , our findings provide evidence that GAB2 is a novel regulator of tumor angiogenesis in NRAS-driven melanoma through regulation of HIF-1a and [VEGF] expressions *mediated* by signaling . Positive_regulation VEGFA MAP2K6 23749166 2820043 inhibitor ( PD98059 ) and PI3K inhibitor ( LY294002 ) decreased ERK and Akt activity , respectively , and *reduced* [VEGF] expression . Positive_regulation VEGFA MMP7 11809536 906419 also upregulated MMP-1 , -2 secretion , but did not *stimulate* [vascular endothelial growth factor] ( VEGF ) secretion . Positive_regulation VEGFA NT5E 23982901 2895996 Our data revealed that tumor derived *enhances* the production of [vascular endothelial growth factor] ( VEGF ) by tumor cells that host derived CD73 is required for in vivo angiogenic responses and that endothelial cells require CD73 expression for tube formation and migration . Positive_regulation VEGFA OXTR 16014624 1453123 showed high affinity binding to VEGF165 ( Kd = 2.2 nm ) , as compared with heparin ( Kd = 15 nm ) , and *potentiated* the affinity of [VEGF165] for VEGF receptor-1 and -2 and for neuropilin-1 . Positive_regulation VEGFA PECAM1 16990600 1673995 [VEGF-A] indeed *induced* a differential expression of VCAM-1 and in endothelial cells . Positive_regulation VEGFA PGC 21364124 2443453 *induces* the expression of vascular endothelial growth factor ( [VEGF] ) in cell culture and in vivo . Positive_regulation VEGFA PGC 21364124 2443455 The *induction* of [VEGF] by requires coactivation of the orphan nuclear receptor estrogen related receptor-a ( ERRa ) and is independent of the hypoxia-inducible factor ( HIF ) pathway . Positive_regulation VEGFA PGC 22516064 2595660 Intense physiological light is involved in choroidal neovascularization through excess outer segment phagocytosis and [VEGF] upregulation *mediated* by in vivo . Positive_regulation VEGFA PGC 23141926 2717873 In skeletal muscle , *induces* [VEGFA] expression and powerfully promotes angiogenesis , suggesting a similar role in other tissues . Positive_regulation VEGFA PGC 23141926 2717875 We show that *induces* the expression of [VEGFA] in numerous retinal cells , and that PGC-1a expression is strongly induced during postnatal retinal development , coincident with VEGFA expression and angiogenesis . Positive_regulation VEGFA PGC 23141926 2717876 These results demonstrate that *regulates* [VEGFA] in the retina and is required for normal vessel development and for pathological neovascularization . Positive_regulation VEGFA PGC 24505137 2928418 strongly *induces* [VEGF] expression , whereas having little effect on mitochondrial genes . Positive_regulation VEGFA PLAT 20110420 2258768 Thus , mobilizes CD11b ( + ) cells from the BM and *increases* systemic and local ( cellular ) [VEGF-A] , which can locally promote angiogenesis during ischemic recovery . Positive_regulation VEGFA PLAT 23280993 2758103 We also showed that rADAMTS13 inhibited *mediated* upregulation of [vascular endothelial growth factor] ( VEGF ) in vascular endothelium after stroke . Positive_regulation VEGFA PLAU 15183452 1255972 We also demonstrate that both TNF-alpha and [VEGF] *induce* upregulated expression of ( u-PA ) . Positive_regulation VEGFA PLAU 17634529 1770484 In 4910 EGFR overexpressing cells , down-regulation of uPAR and *induced* the down-regulation of EGFR and [vascular endothelial growth factor] and inhibited angiogenesis in both in vitro and in vivo angiogenic assays . Positive_regulation VEGFA PLAU 19330806 2080417 Moreover , we found that as well as uPAR *induced* the production of [VEGF] and MMP-9 , and that the down-regulation of uPA/uPAR by siRNAs or B-DIM treatment resulted in the inhibition of VEGF and MMP-9 secretion which could be responsible for the observed inhibition of cell migration . Positive_regulation VEGFA PTGER2 11533709 854678 We conclude that is the major receptor mediating the PGE2 signal generated by COX-2 upregulation in intestinal polyposis , and that *increased* cellular cAMP stimulates expression of more COX-2 and [vascular endothelial growth factor] in the polyp stroma . Positive_regulation VEGFA PTGER2 15970595 1446315 [Vascular endothelial growth factor] induction by prostaglandin E2 in human airway smooth muscle cells is *mediated* by E prostanoid receptors and SP-1 transcription factor binding sites . Positive_regulation VEGFA RCAN1 18840614 1993958 We reported previously that another DSCR1 isoform , DSCR1-1L , was also up-regulated by [VEGF-A] ( 165 ) in cultured endothelial cells and in several in vivo models of pathological angiogenesis and that different from DSCR1-4 , overexpression alone *induced* cultured endothelial cell proliferation and promoted angiogenesis in Matrigel assays . Positive_regulation VEGFA RCAN1 19620774 2118212 We previously reported that [VEGF] *induces* expression in endothelial cells , which in turn negatively feeds back to attenuate endothelial cell activation . Positive_regulation VEGFA S100A7 22189627 2624078 ( S100A7 ) *increases* the expression of ROS and [VEGF] and acts through RAGE to promote endothelial cell proliferation . Positive_regulation VEGFA S100A7 22189627 2624080 In this study we demonstrated that *increased* [VEGF] expression in mammary epithelial cells . Positive_regulation VEGFA S100B 17383127 1735467 In this study , the effect of KIOM-79 on HG or *induced* [VEGF] expression was investigated using 3- ( 4,5-dimethylthiazol-2-yl ) -2,5-diphenyl tetrazolium bromide ( MTT ) assay , RT-PCR , ELISA , and Western blot on human RPE cells . Positive_regulation VEGFA S100B 17383127 1735469 HG or *induced* an increase in expression of [VEGF] at both mRNA and protein levels ( p < 0.05 ; p < 0.01 versus control ) . Positive_regulation VEGFA S100B 21889514 2539104 In RAGE overexpressing myocytes , ( 100 nM ) *resulted* in increases in VEGF mRNA , [VEGF] protein , VEGF secretion , and activation of the transcription factor NF-?B . Positive_regulation VEGFA S100B 21889514 2539107 In myocytes expressing dominant negative RAGE , did not *induce* VEGF mRNA , VEGF protein , [VEGF] secretion or NF-?B activation . Positive_regulation VEGFA TLR7 18375743 1912939 We conclude that multiple ligands *induce* airway epithelial cell production of IL-8 and [VEGF] via a Duox1 -- > ROS -- > TACE -- > TGF-alpha -- > EGFR phosphorylation pathway . Positive_regulation VEGFA TLR7 21998580 2493697 In the current study , we identify HSV-1 infected cells as the dominant source of VEGF-A during acute infection , and [VEGF-A] transcription did not *require* signaling or MAP kinase activation . Positive_regulation VEGFA TLR7 23504259 2809774 Adenosine signaling suppresses the dependent expression of TNF-a , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and *induces* the expression of vascular endothelial growth factor ( [VEGF] ) and IL-10 . Positive_regulation VEGFA TNF 10369746 621779 We could demonstrate in HUAEC that stimulation with IL-1alpha- and *led* to the mRNA expression of basic fibroblast growth factor (bFGF) and [vascular endothelial growth factor] ( VEGF ) which are crucial in the process of angioneogenesis and atherosclerosis as well as of the granulocyte-colony stimulating factor ( G-CSF ) , granulocyte macrophage-colony stimulating factor ( GM-CSF ) and stem cell factor (SCF) which are main growth factors in haematopoiesis . Positive_regulation VEGFA TNF 10403932 629133 RA PBMC [VEGF] production was *up-regulated* by TGF-beta isoforms and and down-regulated by IL-4 and IL-10 , with no effect observed with IL-1beta , IL-6 and IL-8 . Positive_regulation VEGFA TNF 10593330 572627 Lipopolysaccharide and stimulation *resulted* in significantly increased release of PMN [VEGF] ( 532+/-49 and 484+/-80 pg/mL , respectively ; for all , presented as mean +/- SEM ) compared with control experiments ( 32+/-4 pg/mL ) . Positive_regulation VEGFA TNF 10799861 691367 Stimulation of FLS with , IL-1beta , and TGF-beta *increased* [VEGF] production by 1.6- , 2.0- , and 5.2-fold , respectively , and displayed an additive effect on the production of VEGF by CD40L . Positive_regulation VEGFA TNF 10833366 697679 These results suggest that both and TGF-beta1 may *regulate* the production of [VEGF] in early gestational trophoblasts and may therefore serve to modulate placental vascular permeability and angiogenesis that are necessary for embryo implantation and placentation . Positive_regulation VEGFA TNF 10951392 723631 From current knowledge it is possible to hypothesize that metaplastic cells , perhaps as a *consequence* of either or TGFalpha stimulation , secrete [VEGF] . Positive_regulation VEGFA TNF 11063386 746757 Effects of roxithromycin on *induced* [vascular endothelial growth factor] expression in human periodontal ligament cells in culture . Positive_regulation VEGFA TNF 11063386 746758 In the present study , we examined the effects of RXM on *induced* [vascular endothelial growth factor] ( VEGF ) in human periodontal ligament (HPDL) cells . Positive_regulation VEGFA TNF 11063386 746760 Interestingly , the antibiotic roxithromycin inhibits mediated [VEGF] *induction* , suggesting its possible therapeutic utility in periodontitis and other chronic inflammatory conditions involving VEGF induction . Positive_regulation VEGFA TNF 11244034 792273 Clinical investigations in which the activity of TNF alpha in RA patients was blocked with intravenously administered infliximab , a chimeric anti-TNF alpha monoclonal antibody ( mAB ) , has provided evidence that *regulates* IL-6 , IL-8 , MCP-1 , and [VEGF] production , recruitment of immune and inflammatory cells into joints , angiogenesis , and reduction of blood levels of matrix metalloproteinases-1 and -3 . Positive_regulation VEGFA TNF 11280761 798761 Using supershift electrophoretic mobility shift analysis , we found that although induced the nuclear translocation and DNA binding of p65 containing complexes , [VEGF] alone *induced* nuclear translocation and DNA binding of the complexes containing RelB . Positive_regulation VEGFA TNF 11425488 831341 Pretreatment of HaCaT keratinocytes with GSPE upregulated both hydrogen peroxide as well as *induced* [VEGF] expression and release . Positive_regulation VEGFA TNF 12038611 949389 was *required* for this induction of [VEGF] . Positive_regulation VEGFA TNF 12384916 999419 [VEGF] production was potently *induced* by TGFbeta , and to a lesser extent by IL-1beta and , and was further augmented by hypoxia . Positive_regulation VEGFA TNF 12389595 1000386 These results suggest that IL-1beta , IFN-gamma , and may *regulate* the production of [VEGF] in early gestational trophoblasts . Positive_regulation VEGFA TNF 12503703 1026846 Interleukin (IL)-1beta and *augmented* the release of [VEGF] in a time- and dose dependent manner . Positive_regulation VEGFA TNF 12551841 1064175 Also as expected , *induced* [VEGF] expression and secretion in a dose dependent manner . Positive_regulation VEGFA TNF 12574959 1057933 IL-6 and are *involved* in the secretion of [VEGF] by IL-6r expressing myeloma cells . Positive_regulation VEGFA TNF 14972022 1212217 OptiBerry significantly inhibited both H2O2- and *induced* [VEGF] ( Vascular Endothelial Growth Factor ) expression by human keratinocytes . Positive_regulation VEGFA TNF 14991903 1215653 Furthermore , [VEGF] *induced* IL-1beta , IL-6 , , and nitric oxide expression to a small extent and stimulated the proliferation of immortalized chondrocytes . Positive_regulation VEGFA TNF 15134897 1245815 These results indicate that IL-17 up-regulates elaboration of various proangiogenic factors , and modulates macrophage derived *induced* production of KC , MIP-2 , PGE2 and [VEGF] by fibroblasts . Positive_regulation VEGFA TNF 15325633 1287164 IL-17 , IL-1beta and *stimulate* [VEGF] production by dedifferentiated chondrocytes . Positive_regulation VEGFA TNF 15448463 1300592 Both IL-1alpha and *induced* significantly high levels of [VEGF] mRNA gene expression in human pulp and gingival fibroblasts ( p < 0.05 ) . Positive_regulation VEGFA TNF 15811836 1392207 It reached the highest level at 21 hr and returned to the basal level by 42 hr. was significantly elevated only at 4 hr. ufCB *induced* significant increases of [VEGF] in BAL fluid throughout the study period , with the peak increase at 16 hr . Positive_regulation VEGFA TNF 15953572 1421767 Moreover , co-stimulation of PRL with LPS caused activation of HMMs functions , enhancement of HO-1 expression and induction of VEGF release , whereas addition of PRL inhibited up-regulation of HO-1 or [VEGF] *induced* by IFN-gamma or . Positive_regulation VEGFA TNF 16042757 1459691 Taken together , our data suggest that both the secretion of [VEGF] from glioma cells and activation of NFkappaB in endothelial cells *induced* by are necessary for endothelial cell survival as they increase the expression of antiapoptotic genes in endothelial cells under conditions of serum starvation . Positive_regulation VEGFA TNF 16091140 1448055 This study provides evidence to support the anti-inflammatory activity of proanthocyanidins is related to an inhibition of leukocyte infiltration which can be explained at least in part by a down-regulation of endothelial adhesion molecules , ICAM-1 and VCAM-1 and that these compounds are capable of modulating *induced* [VEGF] transcription . Positive_regulation VEGFA TNF 16273763 1479723 Furthermore , up-regulation of secreted MCP-1 and [VEGF] was *observed* following stimulation with . Positive_regulation VEGFA TNF 16311048 1553742 IL-17 , and IL-1beta *increased* [VEGF] secretion by synovial fibroblasts from OA patients . Positive_regulation VEGFA TNF 16311048 1553749 In OA patients IL-17 had an additive effect on *stimulated* [VEGF] secretion . Positive_regulation VEGFA TNF 16438902 1495420 *augmented* the expression of [VEGF165] and VEGF121 mRNA and curcumin reduced the expression ( P < 0.01 ) . Positive_regulation VEGFA TNF 16519794 1574357 Silencing of NFkappaB1 by small interfering RNA abrogated the capacity of RA bone marrow CD34+ cells to differentiate into fibroblast-like cells and to produce MMP-1 and [vascular endothelial growth factor] upon *stimulation* with stem cell factor , granulocyte-macrophage colony stimulating factor and without influencing their viability and capacity to produce beta2-microglobulin . Positive_regulation VEGFA TNF 16586095 1574805 IL-6 ( transiently ) , MCP-1 , NGF and [VEGF] release were *stimulated* by , with an accelerating rate of MCP-1 secretion over 24 h . TNF-alpha has rapid and substantial effects on the synthesis of key inflammation related adipokines in human adipocytes , with highly gene-specific responses . Positive_regulation VEGFA TNF 16728464 1612352 Human progenitor cells from bone marrow or adipose tissue produce [VEGF] , HGF , and IGF-I in *response* to by a p38 MAPK dependent mechanism . Positive_regulation VEGFA TNF 16728464 1612358 We hypothesized that *stimulated* progenitor cell secretion of [vascular endothelial growth factor] ( VEGF ) , hepatocyte growth factor (HGF) , and insulin-like growth factor I (IGF-I) by a p38 mitogen activated protein kinase (MAPK) dependent mechanism . Positive_regulation VEGFA TNF 16728464 1612361 Secretion of [VEGF] , HGF , and IGF-I in hMSCs and hAPCs was significantly *increased* by stimulation with and was associated with increased activation of p38 MAPK . Positive_regulation VEGFA TNF 16728464 1612364 The p38 MAPK inhibitor decreased production of *stimulated* [VEGF] , HGF , and IGF-I in hMSCs and hAPCs . Positive_regulation VEGFA TNF 16803639 1579430 RGD targeted adenovirus delivered the dnIkappaB via alphavbeta3 to become functionally expressed , leading to complete abolishment of induced *up-regulation* of E-selectin , ICAM-1 , VCAM-1 , IL-6 , IL-8 , [VEGF-A] and Tie-2 . Positive_regulation VEGFA TNF 17035941 1649234 SB 203580 , a p38 mitogen activated protein kinase inhibitor , weakly inhibited the induction of VEGF by IL-1beta in a concentration dependent manner , whereas LY 294002 , a phosphoinoside 3-kinase (PI3-K) inhibitor , and rapamycin , a mammalian target of rapamycin (mTOR) inhibitor , strongly inhibited both IL-1beta- and *induced* [VEGF] formation in a concentration dependent manner . Positive_regulation VEGFA TNF 17070836 1675188 Gender differences in injury induced mesenchymal stem cell apoptosis and [VEGF] , TNF , IL-6 expression : *role* of the 55 kDa receptor ( TNFR1 ) . Positive_regulation VEGFA TNF 17084400 1675705 *regulates* [vascular endothelial growth factor] secretion by human oviductal epithelial cells and stromal fibroblasts . Positive_regulation VEGFA TNF 17084400 1675707 *stimulates* the secretion of [vascular endothelial growth factor] by cultured human oviductal epithelial cells and stromal fibroblasts . Positive_regulation VEGFA TNF 17084400 1675708 *stimulated* [vascular endothelial growth factor] secretion by these cells may control oviductal fluid secretion by regulating vascular permeability . Positive_regulation VEGFA TNF 17214640 1681789 Recently , we reported that roxithromycin inhibits *induced* [vascular endothelial growth factor] expression in human periodontal ligament (HPDL) cell cultures . Positive_regulation VEGFA TNF 17216674 1681987 *induces* [vascular endothelial growth factor-C] expression in rheumatoid synoviocytes . Positive_regulation VEGFA TNF 17240354 1690557 These results suggest that p38 MAPK and are *involved* in the [VEGF] expression induced by HKLM in RAW264.7 cells . Positive_regulation VEGFA TNF 17331500 1726413 Despite of the weak *stimulation* of [VEGF] expression by or bFGF alone , co-administration of either of these two cytokines synergized the effect of TGF-beta2 on VEGF mRNA expression and protein production . Positive_regulation VEGFA TNF 17509611 1751076 In *response* to hypoxia or , MSCs produced more [VEGF] , which was correlated with hypoxia or TNF activated p38 MAPK and STAT3 . Positive_regulation VEGFA TNF 17509611 1751078 The p38 MAPK inhibitor significantly decreased hypoxia induced or *stimulated* [VEGF] production in WT. Additionally , STAT3 ablation neutralized hypoxia induced MSC release of VEGF . Positive_regulation VEGFA TNF 17525207 1746132 Analyses of VEGF protein production and mRNA synthesis revealed that [VEGF] *induction* by thrombin plus or coculture with monocytes was additive , whereas that by co-incubation with TGF-beta2 was synergistic . Positive_regulation VEGFA TNF 17906365 1803202 Impaired *induced* [VEGF] expression in human airway smooth muscle cells from smokers with COPD : role of MAPkinases and histone acetylation -- effect of dexamethasone . Positive_regulation VEGFA TNF 17906365 1803203 The effect of cigarette smoking on VEGF expression , the modulatory role of extracellular signal regulated kinase ( ERK ) -1,-2 , p38mitogen activated protein kinase (MAPK) , histone acetylation and the anti-inflammatory effect of dexamethasone on *induced* [VEGF] expression were examined in human airway smooth muscle cells ( HASMC ) of five non-smokers , 17 smokers without airflow limitation and 15 smokers with COPD . Positive_regulation VEGFA TNF 17906365 1803218 *increased* [VEGF] expression 5.4-fold and 4.0-fold in HASMC from non-smokers and smokers without airflow limitation , respectively , but only 2.5-fold in HASMC from smokers with COPD compared with non stimulated HASMC . Positive_regulation VEGFA TNF 17906365 1803233 Dexamethasone ( DEX ; 10 ( -12 ) -10 ( -4 ) M ) reduced TNFalpha induced phosphorylation of ERK-1/-2 and prevented *induced* [VEGF] generation without differences between non-smokers , smokers with and without COPD . Positive_regulation VEGFA TNF 17906365 1803236 The data suggest that HASMC express [VEGF] in *response* to and that this may be reduced in HASMC of smokers with COPD in a smoking independent manner . Positive_regulation VEGFA TNF 18234850 1876842 , LPS , and hypoxia significantly *increased* human MSC [VEGF] , FGF2 , HGF , and IGF-1 production versus controls . Positive_regulation VEGFA TNF 18586687 1966057 Tanshinone I also inhibited *induced* [VEGF] production in MDA-MB-231 cells and migration of MDA-MB-231 cells through extracellular matrix . Positive_regulation VEGFA TNF 18639520 1947626 and IL-1 *induced* [VEGF-A] secretion by corneal fibroblasts ( HCRF ) and this was inhibited significantly by IFN-gamma . Positive_regulation VEGFA TNF 18683887 2020121 *induced* [VEGF] , resulting in neovascularization of disc tissues in a model of HD . Positive_regulation VEGFA TNF 18683887 2020122 The goal of the current research was to investigate the precise role of *induced* [VEGF] and the mechanism of angiogenesis in disc tissues . Positive_regulation VEGFA TNF 18683887 2020123 We performed ELISAs , Western blots , and immunohistological examinations to assess the role of *induced* [VEGF] using organ disc cultures with wild type , TNF receptor 1-null ( TNF-RI ( null ) ) , or TNF receptor 2-null ( TNF-RII ( null ) ) mice . Positive_regulation VEGFA TNF 18683887 2020127 Thus , *induced* [VEGF] expression in disc cells primarily through the NF-kappaB pathway . Positive_regulation VEGFA TNF 18685072 1967762 High-dose TGF-alpha also increased *stimulated* release of [VEGF] from MSCs . Positive_regulation VEGFA TNF 18759025 1034513 [VEGF] may be implicated in the CL formation and maintenance via regulating angiogenesis , and its expression is *regulated* by . Positive_regulation VEGFA TNF 18948845 2053233 Hypertonic saline did not alter *induced* p38 mitogen activated protein kinase phosphorylation or constitutive [vascular endothelial growth factor] expression , suggesting that the observed inhibition is not a generalized suppression of protein phosphorylation or cellular function . Positive_regulation VEGFA TNF 19026990 2022764 MKK4 is a novel target for the inhibition of *induced* [vascular endothelial growth factor] expression by myricetin . Positive_regulation VEGFA TNF 19026990 2022767 We investigated the inhibitory effects of 3,3',4',5,5',7-hexahydroxyflavone ( myricetin ) , an abundant natural flavonoid , on *induced* [VEGF] upregulation and the underlying molecular mechanism . Positive_regulation VEGFA TNF 19026990 2022782 We found that myricetin inhibited *induced* [VEGF] expression in JB6 P+ mouse epidermal cells by targeting MAPK kinase 4 (MKK4) , as well as MEK1 . Positive_regulation VEGFA TNF 19026990 2022787 *induced* [VEGF] expression was inhibited by SP600125 and U0126 , which are inhibitors of JNK and MEK , respectively . Positive_regulation VEGFA TNF 19277666 2119964 In contrast , did not *induce* [VEGF] production from RA-FLS and HUVEC . Positive_regulation VEGFA TNF 19628074 2112812 Recently , we reported that increased the release of vascular endothelial growth factor ( VEGF ) from human MSCs and *augmented* transforming growth factor-alpha ( TGF-alpha ) -stimulated [VEGF] secretion . Positive_regulation VEGFA TNF 19628074 2112813 However , it is unknown whether TNF-alpha stimulates VEGF production via TNF receptor 1 (TNFR1) or 2 ( TNFR2 ) and the mechanism by which *augments* TGF-alpha ( a ligand of epidermal growth factor receptor , EGFR ) stimulated [VEGF] production . Positive_regulation VEGFA TNF 19628074 2112814 We hypothesized that the ablation of TNFR2 would decrease *stimulated* and/or TGF-alpha- stimulated [VEGF] production via MEK dependent mechanisms . Positive_regulation VEGFA TNF 19628074 2112815 or TGF-alpha *increased* [VEGF] secretion in cells transfected with GAPDH or TNFR1 siRNA . Positive_regulation VEGFA TNF 19692652 2150939 We reported previously that transforming growth factor-alpha ( TGF-alpha ) , a putative mediator of wound healing and the injury response , increases the release of vascular endothelial growth factor ( VEGF ) , augments *stimulated* [VEGF] production , and activates mitogen activated protein kinases and phosphatidylinositol 3-kinase (PI-3K) pathway in human MSCs . Positive_regulation VEGFA TNF 19744167 2147234 and TLR-2 , -3 and -4 agonists *induced* the expression of [vascular endothelial growth factor] , which was partially abolished by the blockage of HIF-1 alpha with CTM . Positive_regulation VEGFA TNF 20145121 2208240 Thus , the radioprotective effect of was *mediated* by TAM produced [VEGF] . Positive_regulation VEGFA TNF 20214567 2223130 Blocking of , for instance , *reduces* TNF-alpha induced [VEGF] production . Positive_regulation VEGFA TNF 20550744 2320281 CPE significantly inhibited *induced* up-regulation of [VEGF] via reducing TNF-a induced activation of the nuclear transcription factors activator protein-1 (AP-1) and NF-?B , which are key regulators of VEGF expression . Positive_regulation VEGFA TNF 20561612 2345351 Pretreatment of endometriotic stromal cells with PDTC attenuated *induced* expressions of CD44s , matrix metalloproteinase-9 , and [vascular endothelial growth factor] whereas reversed tumor necrosis factor-a reduced expressions of tissue inhibitor of metalloproteinase-1 revealed by reverse transcriptase polymerase chain reaction and Western blot analysis , suggesting that PDTC may represent a novel therapeutic strategy for treatment of endometriosis . Positive_regulation VEGFA TNF 20586953 2285672 The *induced* secretion of [VEGF] by stromal cells was detected only after 24-h treatment with the highest dose used in the experiment ( 50 ng/ml ; p < 0.05 ) . Positive_regulation VEGFA TNF 20617373 2418883 Expression of interleukin (IL)-6 , IL-8 , and were substantially increased and *involved* in macrophage induced [VEGF] and MMP-9 mRNA expression in MCF-7 cells . Positive_regulation VEGFA TNF 20690185 2368109 IL-1ß and *stimulated* the gene expression of [VEGF] , NGF , and BDNF in nucleus pulposus ( NP ) cells isolated from patient tissues . Positive_regulation VEGFA TNF 21142900 2366352 In addition , the levels of monocyte chemoattractant protein-1 ( MCP-1 ) and were decreased , and tissue inhibitor of metalloproteinases-1 ( TIMP-1 ) and [vascular endothelial growth factor] ( VEGF ) levels were *increased* at 4 weeks in both the IM-C and IM-I groups . Positive_regulation VEGFA TNF 21205894 2379144 IL-25 and also *increased* expression of [VEGF] and VEGF receptors . Positive_regulation VEGFA TNF 21364546 2411505 The mucosal concentration of VEGF-A was also significantly decreased , whereas in vitro exposure of HIF to infliximab virtually abolished *induced* [VEGF-A] production . Positive_regulation VEGFA TNF 21482134 2434058 Leukotriene D4 enhances *induced* [vascular endothelial growth factor] production in human monocytes/macrophages . Positive_regulation VEGFA TNF 21482134 2434059 LTD ( 4 ) significantly induced VEGF production and enhanced *induced* [VEGF] release in THP-1 cells and human peripheral blood CD14+monocytes/macrophages . Positive_regulation VEGFA TNF 21482134 2434060 [VEGF] mRNA expression was also *induced* by stimulation of THP-1 cells with LTD ( 4 ) and . Positive_regulation VEGFA TNF 21482134 2434061 LTD ( 4 ) induced VEGF production and enhanced [VEGF] release *induced* by via CysLT(1) receptors in human monocytes/macrophages . Positive_regulation VEGFA TNF 21673619 2538690 Prior macrophage exposure *increased* the secretion of IL-8 and [VEGF] in response to stimulation whereas IL-6 production was increased in response to IL-1ß . Positive_regulation VEGFA TNF 22351621 2624262 We investigated the effects of low-level laser on the accumulation of HIF-1a , , and interleukin-1ß (IL-1ß) in controlling neuropathic pain , as well as on the *activation* of [vascular endothelial growth factor] ( VEGF ) and nerve growth factor (NGF) in promoting functional recovery in a rat CCI model . Positive_regulation VEGFA TNF 22492973 2613129 In early CL cells , *increased* angiogenic activity ( bovine aortic endothelial cell viability ) and [VEGF] and VEGFR2 mRNA levels and decreased CD36 ( real-time PCR relative quantification ) . Positive_regulation VEGFA TNF 22570350 2614210 Moreover , *enhanced* [VEGF] and iNOS expression by peritoneal macrophage from WT , but not KO mice . Positive_regulation VEGFA TNF 23065888 2689965 *up-regulated* the gene expression of [VEGF] , Angiopoietin-2 , and Tie2 ( p < 0.05 ) . Positive_regulation VEGFA TNF 23066905 2716858 IL-33 augments [VEGF] release *induced* by substance P ( SP ) and release induced by NT . Positive_regulation VEGFA TNF 23504259 2809773 Adenosine signaling suppresses the TLR dependent expression of , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and *induces* the expression of vascular endothelial growth factor ( [VEGF] ) and IL-10 . Positive_regulation VEGFA TNF 23684916 2811154 [VEGF] expression is *enhanced* by , the main pro-inflammatory cytokine in RA . Positive_regulation VEGFA TNF 23684916 2811159 Data suggest that *induced* BAFF expression and BAFF mediated [VEGF] expression in synovium may cooperate to maintain the capacity of such cells to protect B cells from apoptosis and the supply of nutrients and oxygen in inflammatory microenvironments . Positive_regulation VEGFA TNF 23706331 2819582 To investigate the action of nuclear factor ( NF ) -?B in adenomyosis and evaluate the potential therapeutic effect of andrographolide on *induced* expression of NF-?B mediated genes cyclooxygease-2 (COX-2) , [vascular endothelial growth factor] ( VEGF ) , and tissue factor ( TF ) in adenomyotic stromal cells . Positive_regulation VEGFA TNF 23763515 2807526 Vascular endothelial growth factor ( VEGF ) is a pivotal cytokine in the pathogenesis of psoriasis , and *upregulation* of [VEGF] by and inflammatory factors causes marked alterations in the cutaneous microcirculation . Positive_regulation VEGFA TNF 24189030 2890319 Additionally , this extract significantly inhibited the *induced* release of elafin and [VEGF] by PK and NHK . Positive_regulation VEGFA TNF 24280746 2877009 Catar and colleagues demonstrate that transforming growth factor-ß , , and interleukin-1 synergize to significantly *increase* the production and release of [vascular endothelial growth factor] by mesothelial cells , which , if untreated , will promote peritoneal angiogenesis , leading to UFF . Positive_regulation VEGFA TNF 8601593 351900 bFGF and [VEGF165] enhanced of the u-PAR by 72 and 46 % , but itself also *increased* u-PAR in hMVEC by 30 % . Positive_regulation VEGFA TNF 8910439 395061 Of various cytokines and growth factors , basic fibroblast growth factor (bFGF) , , and interleukin 1 most potently *enhanced* [VEGF] mRNA levels of a glioma cell line , U251 . Positive_regulation VEGFA TNF 8910439 395089 Mithramycin , an inhibitor of SP-1 , at 1-10 nM inhibited *activation* of the [VEGF] gene by bFGF or but not that by hypoxia . Positive_regulation VEGFA TNF 8910439 395092 The promoter activity of the [VEGF] gene , which contains five SP-1 binding sites and one AP-1 binding site but not hypoxia regulatory elements , was *enhanced* by bFGF or but not by hypoxia . Positive_regulation VEGFA TNF 9146665 429732 Induction of DU-145 cells with cytokines resulted in differential stimulation whereby was a potent *inducer* of [VEGF] , and IL-1 produced lesser but statistically significant increases in VEGF expression . Positive_regulation VEGFA TNF 9177300 434148 We further demonstrate the expression of [VEGF] by cultured human gastric fibroblasts which is *enhanced* by . Positive_regulation VEGFA TNF 9199336 438914 Administration of a NF-kappaB antisense oligonucleotide almost completely inhibited TNF-alpha dependent IL-8 production and partially abrogated *dependent* [VEGF] production , and an Sp1 antisense sequence partially inhibited TNF-alpha dependent production of VEGF . Positive_regulation VEGFA TNF 9354686 461664 The present work shows that phorbol-12-myristate 13-acetate ( PMA ) , fMet-Leu-Phe , and *triggered* a time dependent secretion of [VEGF] by human neutrophils . Positive_regulation VEGFA TNF 9457313 484586 Induction of DU-145 cells with cytokines resulted in differential stimulation whereby was the predominant *inducer* of [VEGF] , whereas IL-1 was the predominant inducer of IL-8 . Positive_regulation VEGFA TNF 9602864 506732 Conversely , UVA1R ( 5 and 7 J/cm2 ) did not modify the basal level of [VEGF] and did not *induce* the secretion of by keratinocytes . Positive_regulation VEGFA TNF 9933439 589419 six times more VEGF was secreted when cells were stimulated by TGF-beta than when stimulated by PDGF or IL-1 for 24 h . and bFGF did not *stimulate* any secretion of [VEGF] . Positive_regulation VEGFA ZFP57 12415262 1020415 In addition , the neovasculature resulting from *induced* expression of [Vegfa] was not hyperpermeable as was that produced by expression of murine Vegfa ( 164 ) cDNA . Positive_regulation VEGFA ZFP57 16423874 1527671 These data demonstrate that *activation* of the endogenous [VEGFa] gene by an engineered can induce angiogenesis in a clinically relevant model and further document the feasibility of designing ZFPs to therapeutically regulate gene expression in vivo . Positive_regulation VEGFA ZFP57 23062640 2685744 RT-PCR result showed [VEGF-A] mRNA expression level *induced* by was high than that induced by VEGF165 . Positive_regulation VEGFC EMP1 24338711 2926795 *regulates* caspase-9 and [VEGFC] expression and suppresses prostate cancer cell proliferation and invasion . Positive_regulation VEGFC EPHB2 23424645 2744182 Furthermore , inhibition of *blocked* the induction of [VEGF-C] gene . Positive_regulation VEGFC IL1B 9525952 495682 and tumor necrosis factor-alpha also *stimulated* the production of [VEGF-C] protein by the fibroblasts . Positive_regulation VEGFC MAP2K6 21074412 2382922 In both cell lines stimulated with endogenous or exogenous ligand , inhibition of MEK1/2 ( with U0126 or PD98059 ) or PI3K ( with PI-103 or LY294002 ) resulted in a marked reduction of EGFR induced VEGF-A expression , whereas exogenous EGF induced [VEGF-C] upregulation was *blocked* by inhibitors of but not PI3K . Positive_regulation VEGFC TNF 12471041 1055503 NF-kappa B has been shown to be probably involved in interleukin-1 beta- or *induced* [VEGF-C] mRNA expression in human fibroblasts . Positive_regulation VEGFC TNF 16943230 1708768 In retinal endothelial cells , *stimulates* the expression of [VEGF-C] , which in turn protects endothelial cells from apoptosis induced by TNFalpha or hyperglycaemia via VEGFR-2 and thus helps sustain retinal neovascularisation . Positive_regulation VEGFC TNF 9525952 495681 IL-1beta and also *stimulated* the production of [VEGF-C] protein by the fibroblasts . Positive_regulation VIM HBEGF 22592159 2643445 Immunostaining revealed *induced* expression of the mesenchymal protein [vimentin] and decreased expression of E-cadherin , as well as nuclear translocation of ß-catenin . Positive_regulation VIM NES 9645943 514919 A wild-type rat nestin gene transfected into the IF-free SW13 cell line failed to assemble into a filamentous network but was incorporated into the existing IF network of a subclone expressing vimentin , demonstrating that *requires* [vimentin] for proper assembly . Positive_regulation VIM SUSD2 25045846 2953413 The mRNA and protein levels of vimentin , twist , SUSD2 , and uPA were significantly decreased in p63-knockdown ESC cells , while overexpression of p63 *induced* an increase in [vimentin] , , and uPA . Positive_regulation VIM TNF 12483219 1037796 In contrast , the pro-inflammatory cytokine can *trigger* secretion of [vimentin] . Positive_regulation VIMP IL1B 16574427 1550019 [SEPS1] gene expression , protein levels and promoter activity were all *increased* 2-3-fold by TNF-alpha and in HepG2 cells . Positive_regulation VIMP TNF 16574427 1550018 [SEPS1] gene expression , protein levels and promoter activity were all *increased* 2-3-fold by and IL-1beta in HepG2 cells . Positive_regulation VIP IL1B 16095565 1448113 Furthermore , stimulated IL-6 promoter activity in the osteoblastic cell line MC3T3-E1 stably transfected with a human IL-6 promoter/luciferase construct , and both [VIP] , and the related neuropeptide PACAP-38 , *increased* the effect of IL-1beta in a synergistic manner . Positive_regulation VIP IL1B 2036955 159765 In the presence of [VIP] and PGE2 , IL-1 alpha and *increased* IL-6 release without any apparent further change in extracellular or intracellular cAMP . Positive_regulation VIP IL1B 8983969 402001 The interleukin 1 effect could not be reproduced by replacing interleukin-1 beta with tumor necrosis factor-alpha or bacterial lipopolysaccharide and was specific for prostaglandin E2 , since did not *enhance* isoproterenol- , [vasoactive intestinal peptide-] , or forskolin induced adenosine 3',5'-cyclic monophosphate production . Positive_regulation VIP NR2F1 21430164 2406325 Conditional loss of function of in subventricular precursors and postmitotic cells *leads* to a decrease of late-born , CGE derived , [VIP] ( vasoactive intestinal peptide ) - and CR ( calretinin ) -expressing bipolar cortical neurons , compensated by the concurrent increase of early-born MGE derived , PV ( parvalbumin ) -expressing interneurons . Positive_regulation VIP TNF 12225791 987850 [VIP] *induced* the production of TGF-beta and in BM mononuclear cells and stroma . Positive_regulation VIP TNF 20372827 2238931 Forskolin , a direct activator of adenylyl cyclase , or 8-bromoadenosine-3',5'-cyclic monophosphate ( 8bromo-cAMP ) , a plasma membrane-permeable cAMP analogue , markedly enhanced the *induced* IL-6 synthesis as well as [VIP] . Positive_regulation VIP TNF 7497530 335851 [VIP] at all concentrations tested did not *induce* production and was similar to untreated control cultures . Positive_regulation VIP TNS1 6714637 37436 The results suggest that the *induced* increase in plasma [VIP] parallels the increase in skin temperature in the extremities . Positive_regulation VIPR2 TLR7 20196778 2180933 We now report that different ligands selectively *regulate* the [VPAC(2)] receptor gene and show a gene repression system controlled by key protein kinase signalling cascades in macrophages . Positive_regulation VIT CD14 15766397 1383651 To observe the 1 , 25-dihydroxy [vitamin D3 (Vit D3)] *induced* expression in human U937 cell line and the reaction of the cells to LPS stimulation following the induction . Positive_regulation VLDLR PCSK9 21273557 2403164 Expression of in the liver of Pcsk9 ( -/- ) females *reestablished* both circulating PCSK9 and normal [VLDLR] levels . Positive_regulation VLDLR PCSK9 21273557 2403165 In vivo , endogenous *regulates* [VLDLR] protein levels in adipose tissue . Positive_regulation VLDLR PCSK9 23221398 2731344 is *involved* in the degradation of LDLR and [VLDLR] . Positive_regulation VLDLR PCSK9 24103783 2863574 Replacement of EGF-A in the very low density lipoprotein receptor ( VLDLR ) with EGF-A of the LDLR promoted the degradation of the mutant [VLDLR] *induced* by . Positive_regulation VLDLR PLAU 20624392 2297145 However , complex , *increased* type II [VLDLR] expression with promoted cell proliferation and migration and stabilization of beta-catenin . Positive_regulation VPS13B TNF 14573654 1155982 In a human whole-blood assay system , GBS type III [COH-1] potently *induced* substantial monocyte release in adult peripheral blood and , due to a higher concentration of monocytes , 10-fold-greater TNF-alpha release in newborn cord blood . Positive_regulation VSNL1 CA2 18925431 2028658 In order to test this hypothesis we have investigated whether a nicotine induced and reversible Ca2+-myristoyl switch of VILIP-1 exists in primary hippocampal neurons and whether pharmacological agents , such as antagonist specific for distinct nAChRs , can interfere with the *dependent* membrane localization of [VILIP-1] . Positive_regulation VSNL1 GUF1 16703469 1624705 Studies on the truncated mutants showed that the intact EF-3 and were *essential* for the binding of [VILIP1] with Ca2+ and Mg2+ . Positive_regulation VSNL1 PRDX2 18301774 1873488 , a histone deacetylase inhibitor , potently *induced* [VILIP-1] expression , indicating that histone deacetylation is an additional mechanism of VILIP-1 silencing . Positive_regulation VTN NR2F1 11117523 759325 Accordingly , vitronectin mRNA levels were shown to be up-regulated by COUP-TFI by RT-PCR analysis , and *stimulated* the mouse [vitronectin] promoter activity in transient transfection assays . Positive_regulation VTN NR2F1 12040019 949617 After showing that COUP-TFI is phosphorylated in vivo , we provide evidence that in vivo inhibition of either MAPK or PKC signaling pathway leads to a specific and pronounced decrease in *dependent* transcriptional activation of the [vitronectin] gene promoter . Positive_regulation VTN PLAU 11501527 847202 Furthermore , uPAR- ( 154 -- 176 ) increased uPAR transfected BAF3-cell adhesion on [vitronectin] in the *presence* of , whereas uPAR- ( 247 -- 276 ) stimulated the cell adhesion both in the absence or presence of uPA . Positive_regulation VTN TNF 23619393 2790343 TGF-ß1 expression in microglia was *increased* by [vitronectin] and to a lesser extent by and LPS , but astrocyte TGF-ß1 expression was not regulated by any factor tested . Positive_regulation VWF CAPN8 8896411 392680 Investigation of the mechanisms involved in shear dependent microparticle generation showed that binding of [von Willebrand factor (vWF)] to platelet glycoprotein lb , influx of extracellular calcium , and *activation* of platelet were required to generate microparticles under high shear stress conditions . Positive_regulation VWF EDN2 2125563 146740 The calcium antagonists nifedipine , diltiazem and verapamil partially inhibited endothelin induced t-PA release , but had no effect on *induced* [vWF] release . Positive_regulation VWF F2R 22952809 2667487 peptide *induced* GEC [vWF] release to the same extent as PR3 . Positive_regulation VWF F2R 22952809 2667489 However , knockdown of PARs by small interfering RNA showed that neither nor PAR2 activation caused PR3 or elastase *mediated* [vWF] release . Positive_regulation VWF F2R 8987167 404120 Both , the activation of the with thrombin or SFLLRN and the activation of the PAR-2 with trypsin or SLIGRL *induced* intracellular calcium mobilisation and a subsequent release of [von Willebrand factor (vWf)] from Weibel-Palade bodies . Positive_regulation VWF TNF 12212197 767347 BHD can inhibit the expression of TF and the release of [vWF] *induced* by . Positive_regulation VWF TNF 1509401 196522 *induces* [von Willebrand factor] release in healthy humans . Positive_regulation VWF TNF 1509401 196525 induced a marked *increase* in [vWF] antigen plasma levels , becoming significant after 45 min and peaking after 4 h ( percentage increase from base line : 351 +/- 46 ; p less than 0.0001 , TNF versus saline ) . Positive_regulation VWF TNF 18642698 1840853 and lipopolysaccharide did not *stimulate* secretion of [von Willebrand factor] , but significantly increased the expression of ICAM-1 . Positive_regulation WAS CAPN8 17141616 1653664 WIP exerts these functions by regulating *mediated* cleavage of [WASP] and by facilitating the localization of WASP to sites of actin polymerization at podosomes . Positive_regulation WAS CAPN8 9731041 530405 Lastly , we found that [WASP] is cleaved in *response* to activation of , a protease that may have a role in postaggregation signaling processes . Positive_regulation WASF1 MMP28 14536061 1152483 [WAVE1] is colocalized with ECM degrading enzyme MMP-2 in dorsal ruffles , and WAVE1- , but not WAVE2- , dependent migration *requires* activity . Positive_regulation WASF1 MMP7 14536061 1152498 WAVE1 is colocalized with ECM degrading enzyme MMP-2 in dorsal ruffles , and [WAVE1-] , but not WAVE2- , dependent migration *requires* activity . Positive_regulation WASF2 MMP28 14536061 1152506 WAVE1 is colocalized with ECM degrading enzyme MMP-2 in dorsal ruffles , and WAVE1- , but not [WAVE2-] , dependent migration *requires* activity . Positive_regulation WASF2 MMP7 14536061 1152521 WAVE1 is colocalized with ECM degrading enzyme MMP-2 in dorsal ruffles , and WAVE1- , but not [WAVE2-] , dependent migration *requires* activity . Positive_regulation WASL EPHB2 15169891 1253631 phosphorylation and a mimicking S405,418D double mutation *enhanced* cortactin binding and activation of [N-WASP] . Positive_regulation WDR5 TNF 16386180 1494191 Cytokines are the direct mediators for multiple organ failure (MOF) , and [MOF] is *triggered* by and a cascade of cytokine release , with a prolonged high-expression of IL-6 . Positive_regulation WDR61 ALOX5 1650153 162976 Taken together , our studies indicate that [PAF] can significantly augment lung NK cell activity and that this effect is *dependent* on PKC , <5-lipoxygenase> , and extracellular calcium . Positive_regulation WDR61 ALOX5 3152458 104197 This suggests that <5-lipoxygenase> *dependent* mediators and [PAF] are involved in allergic contact dermatitis and that these mediators play only a minor role in irritant dermatitis . Positive_regulation WDR61 ALOX5 6089913 41333 The specific <5-lipoxygenase> inhibitor , 6,8-de-epoxy-6,9- ( phenylimino ) delta 6,8-prostaglandin I1 ( U-60257 ) , *inhibits* [PAF-acether] , but not leukotriene B4-mediated chemotaxis . Positive_regulation WDR61 ALOX5 8415804 234044 Although the early pulmonary vascular response ( < 10 min ) to PAF is dependent on cyclooxygenase products , the sustained response ( after 10 min ) can not be explained by either <5-lipoxygenase> or cyclooxygenase products but may be *mediated* directly by [PAF] receptors . Positive_regulation WDR61 ANGPT1 16617006 1624492 *mediated* endothelial [PAF] synthesis requires the activation of the p38 and p42/44 MAPKs , PI3K intracellular signalling pathways , and a secreted phospholipase A(2) ( sPLA ( 2 ) -V ) . Positive_regulation WDR61 CHI3L1 8245706 236929 On the other hand , the release of [platelet activating factor (PAF)] induced by opsonized particles was *enhanced* only by and not by CGP41-251 and CGP44-800 . Positive_regulation WDR61 EDN2 2051719 161794 In addition , induced a significant *increase* in the production of [PAF] by isolated glomeruli ( Basal , 81 +/- 10 pg/mg protein ; endothelin , 10 ( -7 ) M , 140 +/- 18 pg/mg protein ) . Positive_regulation WDR61 EDN2 8898708 393087 *stimulates* phosphoinositide hydrolysis and [PAF] synthesis in brain microvessels . Positive_regulation WDR61 HBEGF 17322418 1747799 Increased alkaline phosphatase ( AP ) activity after PAF treatment in AP-HB-EGF fusion construct transfected SMCs indicated that [PAF] *induced* the release of within 1 min. Gelatin zymography data showed that PAF stimulated MMP-2 activity and MMP-9 activity within 1 min . Positive_regulation WDR61 IL1B 10447739 577417 We conclude that CRH and [PAF] can *induce* the expression of , but this is not obligatory for increased PGE2 release , and the effect of these stimuli on COX-2 expression is a direct , IL-1beta independent effect . Positive_regulation WDR61 IL1B 1519663 196914 Stimulation of isolated mouse alveolar macrophages with recombinant murine or IL-1 alpha *resulted* in rapid , dose dependent , and cell concentration dependent increases in [PAF] secretion . Positive_regulation WDR61 IL1B 16807360 1612754 In circular muscle , exogenous [PAF] *induced* sequential formation of IL-6 , H ( 2 ) O ( 2 ) , , and PAF . Positive_regulation WDR61 IL1B 16829183 1591456 Both TNF-alpha and induced HUVEC platelet activating factor (PAF) production and [PAF] was *required* for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine ) . Positive_regulation WDR61 IL1B 7882558 298864 and IL-6 *stimulate* the production of [platelet activating factor (PAF)] by cultured rabbit synovial cells . Positive_regulation WDR61 IL1B 8080039 270824 and tumor necrosis factor-alpha *induce* [PAF] production by endothelium , and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist . Positive_regulation WDR61 ITGB2 7902855 245062 Ligation of was not *sufficient* for [PAF] synthesis suggesting that an additional receptor was involved . Positive_regulation WDR61 LBP 7541418 310468 Moreover , LeuM3 , 28C5 , and 18E12 mAbs that were themselves unable to stimulate the synthesis of PAF blocked [PAF] synthesis *initiated* by complex . Positive_regulation WDR61 LBP 7541418 310473 was *required* for synthesis of [PAF] by MO . Positive_regulation WDR61 MAP2K6 10606930 655854 The results showed that TNF alpha , IL-1 alpha and [PAF] *induced* serine phosphorylation of MKK3 and , and p38 MAP kinase activation in BECs . Positive_regulation WDR61 MUC16 9620929 510806 In rat tracheas studied by in situ hybridization , [PAF] *induced* MUC5 gene expression in epithelial cells that stained for mucosubstances . Positive_regulation WDR61 PLAT 1521562 196955 Using a perfused rat hindleg system , release of from endothelial cells could be *induced* by [platelet activating factor (PAF)] , bradykinin , substance P , thrombin , carbachol and A23187 , while this release was inhibited by mepacrine and by nor-dihydroguaiaretic acid . Positive_regulation WDR61 TGM2 7679111 211210 The finding that competitive inhibitors of significantly *inhibited* [C-PAF] release , enhancement of MC540 staining , and externalization of phosphatidylserine , strongly suggest a role for this enzyme in the enhancement of phospholipid transbilayer movement . Positive_regulation WDR61 TNF 10409262 630034 Both and interleukin-1 modestly *increased* plasma [PAF-AH] activity and mRNA levels in liver and spleen , suggesting that they may partly mediate the effect of LPS on PAF-AH . Positive_regulation WDR61 TNF 10435033 634217 ( 4 ) the synthesis of [PAF] *induced* by . Positive_regulation WDR61 TNF 11080081 749569 *increased* the production of [PAF] and NO . Positive_regulation WDR61 TNF 12428690 1014873 Synthesis of [PAF] was not *inducible* by in murine F10-M3 melanoma cells . Positive_regulation WDR61 TNF 15702351 1382772 Finally , up to 2 mug/ml , [PAF] did not *induce* the production of pro-inflammatory cytokines such as IL-6 , IL-8 , and . Positive_regulation WDR61 TNF 1668105 176690 [PAF] *induced* maximal synthesis 2-3 hr after monocyte stimulation as assessed by dot blotting of cell associated TNF alpha using polyclonal anti-TNF antibody . Positive_regulation WDR61 TNF 16829183 1591455 Both and IL-1beta induced HUVEC platelet activating factor (PAF) production and [PAF] was *required* for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine ) . Positive_regulation WDR61 TNF 18180165 1863039 *induces* [platelet activating factor (PAF)] synthesis in many inflammatory cells . Positive_regulation WDR61 TNF 18180165 1863044 We found that , although both cultures synthesized PAF at a similar basal rate , *induced* [PAF] synthesis in adipocytes was 7-fold higher than in preadipocytes . Positive_regulation WDR61 TNF 18180165 1863049 Wortmannin enhanced *dependent* [PAF] synthesis in adipocytes but not in preadipocytes , indicating the negative control by PI3K in mature cells . Positive_regulation WDR61 TNF 20016469 2204615 , which is assumed to mediate the interaction between mesangial cells and podocytes , also *induces* the expression of [platelet activating factor (PAF)] . Positive_regulation WDR61 TNF 20423922 2437239 In rats , increased hydraulic conductivity 2.5-fold over baseline and [PAF] *increased* it 5-fold ; Positive_regulation WDR61 TNF 2137857 128814 The peptide HDMNKVLDL ( antiflammin-2 ) inhibits the synthesis of [platelet activating factor (PAF)] *induced* by or phagocytosis in rat macrophages and human neutrophils , and by thrombin in vascular endothelial cells . Positive_regulation WDR61 TNF 2266661 147302 Inhibitors of PAF synthesis , such as plasma alpha 1-proteinase inhibitor and an anti-inflammatory peptide , blocked changes induced by TNF , PAF receptor antagonists inhibited changes *induced* by [PAF] and also by . Positive_regulation WDR61 TNF 2801951 119979 Since *stimulates* [PAF] synthesis in vitro , we tested the hypothesis that PAF mediates TNF induced lung injury in vivo using specific PAF receptor antagonists . Positive_regulation WDR61 TNF 3049910 99311 and IL-1 *stimulate* the synthesis and release of [platelet activating factor (PAF)] by neutrophils and vascular endothelial cells . Positive_regulation WDR61 TNF 3049910 99318 Low concentrations of this antiproteinase and of human plasma alpha 1-antichymotrypsin inhibited *induced* [PAF] synthesis in neutrophils , macrophages , and vascular endothelial cells . Positive_regulation WDR61 TNF 3119758 80238 Synthesis of [PAF] in *response* to was also detected in rat polymorphonuclear neutrophils , but not in human tumor cells and dermal fibroblasts . Positive_regulation WDR61 TNF 3261295 95992 About 30 % of [PAF] produced in *response* to either or IL-1 is released into the medium , whereas approximately 70 % remains cell associated . Positive_regulation WDR61 TNF 3261295 96009 Experiments with labeled precursors show that [PAF] is synthesized de novo in *response* to . Positive_regulation WDR61 TNF 3261295 96019 This suggests that [PAF] is synthesized by the same pathway in *response* to or IL-1 . Positive_regulation WDR61 TNF 3366898 93071 In the present study , we have shown that ( a ) *caused* [PAF] production in bowel tissue ; Positive_regulation WDR61 TNF 7516414 257608 These results suggest that the angiogenic effect of is , at least in part , *mediated* by [PAF] synthesized from monocytes and/or endothelial cells infiltrating the Matrigel plug . Positive_regulation WDR61 TNF 7681399 214260 In conclusion , the *enhancement* of [PAF] responses by , associated with functional characteristics of differentiation in Mono Mac 6 cells , may represent a specific mechanism of cooperative interaction between PAF and TNF in inflammation , sepsis , immunoregulation and atherogenesis . Positive_regulation WDR61 TNF 7821968 285555 We have shown previously that endotoxin , tumour necrosis factor (TNF) and platelet activating factor (PAF) are important in the pathogenesis of bowel injury , and that endotoxin and *induce* [PAF] formation in bowel tissue . Positive_regulation WDR61 TNF 7882905 289172 Because the release of [PAF] is *stimulated* by , this study was designed to measure the effects of polyI : C on TNF induced lung inflammation and injury . Positive_regulation WDR61 TNF 8080039 270823 Interleukin-1 beta and *induce* [PAF] production by endothelium , and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist . Positive_regulation WDR61 TNF 9394802 468197 These data suggest that [PAF] , which is released immediately or shortly after LPS injection , *induces* the expression of through the activation of NF-kappa B . Positive_regulation WFDC2 MUC16 21549107 2440378 levels of pregnant women were higher than those of control group , and [HE4] was *increased* in chronic renal diseases . Positive_regulation WFDC2 MUC16 22962406 2693431 was lower in women age =55 , and [HE4] *increased* with age ( P < 0.01 ) , particularly among women age =55 . Positive_regulation WFDC2 MUC16 22967799 2693524 [HE4] levels *increased* significantly with age ( p=0.02 ) , FIGO stage ( p < 0.0001 ) , grade ( p=0.005 ) , preoperative levels ( p < 0.0001 ) , and residual tumor ( p < 0.0001 ) . Positive_regulation WIF1 ADIPOQ 18701434 1979650 *stimulates* [Wnt inhibitory factor-1] expression through epigenetic regulations involving the transcription factor specificity protein 1 . Positive_regulation WIF1 AMH 24362065 2899824 *Induction* of [WNT inhibitory factor 1] expression by Müllerian inhibiting in the Müllerian duct mesenchyme is linked to Müllerian duct regression . Positive_regulation WIF1 BMP1 19700758 2133292 Furthermore , signaling *stimulated* [Wnt inhibitory factor-1] expression and promoter activity in cultured tumor cells and HaCaT keratinocytes , as well as inhibited Shh expression , as compared with the corresponding controls . Positive_regulation WIF1 BMP10 19700758 2133300 Furthermore , signaling *stimulated* [Wnt inhibitory factor-1] expression and promoter activity in cultured tumor cells and HaCaT keratinocytes , as well as inhibited Shh expression , as compared with the corresponding controls . Positive_regulation WIF1 BMP15 19700758 2133293 Furthermore , signaling *stimulated* [Wnt inhibitory factor-1] expression and promoter activity in cultured tumor cells and HaCaT keratinocytes , as well as inhibited Shh expression , as compared with the corresponding controls . Positive_regulation WIF1 BMP2 19700758 2133294 Furthermore , signaling *stimulated* [Wnt inhibitory factor-1] expression and promoter activity in cultured tumor cells and HaCaT keratinocytes , as well as inhibited Shh expression , as compared with the corresponding controls . Positive_regulation WIF1 BMP3 19700758 2133295 Furthermore , signaling *stimulated* [Wnt inhibitory factor-1] expression and promoter activity in cultured tumor cells and HaCaT keratinocytes , as well as inhibited Shh expression , as compared with the corresponding controls . Positive_regulation WIF1 BMP4 19700758 2133296 Furthermore , signaling *stimulated* [Wnt inhibitory factor-1] expression and promoter activity in cultured tumor cells and HaCaT keratinocytes , as well as inhibited Shh expression , as compared with the corresponding controls . Positive_regulation WIF1 BMP5 19700758 2133297 Furthermore , signaling *stimulated* [Wnt inhibitory factor-1] expression and promoter activity in cultured tumor cells and HaCaT keratinocytes , as well as inhibited Shh expression , as compared with the corresponding controls . Positive_regulation WIF1 BMP6 19700758 2133298 Furthermore , signaling *stimulated* [Wnt inhibitory factor-1] expression and promoter activity in cultured tumor cells and HaCaT keratinocytes , as well as inhibited Shh expression , as compared with the corresponding controls . Positive_regulation WIF1 BMP7 19700758 2133299 Furthermore , signaling *stimulated* [Wnt inhibitory factor-1] expression and promoter activity in cultured tumor cells and HaCaT keratinocytes , as well as inhibited Shh expression , as compared with the corresponding controls . Positive_regulation WIF1 MITF 24131586 2889341 The upregulation of [WIF-1] on cultured normal human melanocytes significantly *induced* expressions of and tyrosinase , which were associated with increased melanin content and tyrosinase activity . Positive_regulation WIF1 MYLIP 23939044 2835861 Methylation-specific PCR and Western blotting indicated that positively *regulate* [WIF-1] expression by inhibiting the methylation of its promoter . Positive_regulation WIF1 SMAD1 21986617 2539641 directly *regulates* [Wif1] gene expression and blockade of Smad1 function in fetal LECs is reported to downregulate Wif1 gene expression . Positive_regulation WIF1 SP1 18701434 1979664 Using silencing RNA approaches , we confirmed that downregulation of *resulted* in an increased expression of [WIF1] and decreased methylation of WIF1 promoter . Positive_regulation WIF1 TYR 24131586 2889340 The upregulation of [WIF-1] on cultured normal human melanocytes significantly *induced* expressions of MITF and , which were associated with increased melanin content and tyrosinase activity . Positive_regulation WIF1 WNT1 16427602 1515831 [Wnt inhibitory factor-1 (WIF-1)] is a secreted antagonist of Wnt signaling and *acts* through direct binding to in the extracellular space . Positive_regulation WIF1 WNT1 17472570 1738288 [Wnt inhibitory factor-1 (WIF-1)] is a secreted antagonist of Wnt signaling and *acts* through direct binding to in the extracellular space . Positive_regulation WIF1 WNT11 16427602 1515832 [Wnt inhibitory factor-1 (WIF-1)] is a secreted antagonist of Wnt signaling and *acts* through direct binding to in the extracellular space . Positive_regulation WIF1 WNT11 17472570 1738289 [Wnt inhibitory factor-1 (WIF-1)] is a secreted antagonist of Wnt signaling and *acts* through direct binding to in the extracellular space . Positive_regulation WIF1 WNT16 16427602 1515837 [Wnt inhibitory factor-1 (WIF-1)] is a secreted antagonist of Wnt signaling and *acts* through direct binding to in the extracellular space . Positive_regulation WIF1 WNT16 17472570 1738294 [Wnt inhibitory factor-1 (WIF-1)] is a secreted antagonist of Wnt signaling and *acts* through direct binding to in the extracellular space . Positive_regulation WIF1 WNT2 16427602 1515833 [Wnt inhibitory factor-1 (WIF-1)] is a secreted antagonist of Wnt signaling and *acts* through direct binding to in the extracellular space . Positive_regulation WIF1 WNT2 17472570 1738290 [Wnt inhibitory factor-1 (WIF-1)] is a secreted antagonist of Wnt signaling and *acts* through direct binding to in the extracellular space . Positive_regulation WIF1 WNT2B 21550190 2440668 WNT5A , WNT11 and [WIF-1] were upregulated on P14 and P18 , but *increased* only on P14 . Positive_regulation WIF1 WNT3 16427602 1515834 [Wnt inhibitory factor-1 (WIF-1)] is a secreted antagonist of Wnt signaling and *acts* through direct binding to in the extracellular space . Positive_regulation WIF1 WNT3 17472570 1738291 [Wnt inhibitory factor-1 (WIF-1)] is a secreted antagonist of Wnt signaling and *acts* through direct binding to in the extracellular space . Positive_regulation WIF1 WNT4 16427602 1515835 [Wnt inhibitory factor-1 (WIF-1)] is a secreted antagonist of Wnt signaling and *acts* through direct binding to in the extracellular space . Positive_regulation WIF1 WNT4 17472570 1738292 [Wnt inhibitory factor-1 (WIF-1)] is a secreted antagonist of Wnt signaling and *acts* through direct binding to in the extracellular space . Positive_regulation WIF1 WNT6 16427602 1515836 [Wnt inhibitory factor-1 (WIF-1)] is a secreted antagonist of Wnt signaling and *acts* through direct binding to in the extracellular space . Positive_regulation WIF1 WNT6 17472570 1738293 [Wnt inhibitory factor-1 (WIF-1)] is a secreted antagonist of Wnt signaling and *acts* through direct binding to in the extracellular space . Positive_regulation WISP1 TNF 17616748 1786954 IL-1beta and expression preceded WISP-1 expression in vivo and *stimulated* [WISP-1] expression in neonatal rat ventricular myocytes in vitro . Positive_regulation WISP1 TNF 19339243 2074328 Previously we demonstrated that [WISP1] is up-regulated in post-infarct heart , stimulates cardiac fibroblast proliferation , and is *induced* by the proinflammatory cytokine . Positive_regulation WISP1 TNF 19339243 2074329 Here we investigated ( i ) the localization of TNF-alpha and WISP1 in post-infarct heart , ( ii ) the mechanism of mediated [WISP1] *induction* in primary human cardiac fibroblasts ( CF ) , ( iii ) the role of WISP1 in TNF-alpha mediated CF proliferation and collagen production , and ( iv ) the effects of WISP1 on TNF-alpha mediated cardiomyocyte death . Positive_regulation WISP1 TNF 19339243 2074331 In CF , potently *induced* [WISP1] expression in cyclic AMP response element binding protein ( CREB ) -dependent manner . Positive_regulation WISP1 TNF 19339243 2074341 TNF-alpha induced CREB activation via ERK1/2 , and inhibition of ERK1/2 and CREB blunted mediated [WISP1] *induction* . Positive_regulation WISP1 TNF 23807044 2828678 [CCN4] expression was *enhanced* by the pro-inflammatory cytokine . Positive_regulation WISP1 TNF 24600972 2925059 [WISP-1] was significantly *induced* in HSC-T6 cells by and in LX-2 cells by TGF-beta1 . Positive_regulation WNK1 CAPN8 14686903 1179454 However , inhibition of the glutamate activated Ca2+ dependent protease by calpeptin completely blocked IkappaBalpha degradation and *reduced* the nuclear translocation of [p65] . Positive_regulation WNK1 CAPN8 16547594 1568166 Since purified m- or mu-calpain degraded NF-kappaB p65 in vitro , it is possible that calpastatin suppressed *mediated* degradation of NF-kappaB [p65] . Positive_regulation WNK1 EPHB2 15192014 1295264 Here we show that TNF-alpha induces greater *dependent* [p65] phosphorylation at S536 in transformation sensitive ( P+ ) cells than in P- cells . Positive_regulation WNK1 EPHB2 24345501 2880880 TNF-a stimulated significantly phosphorylation on Ser536 of [NF-?B/p65] , Ser473 of Akt at 5-15 min , and *activations* of IKK-ß and at 15-30 min. Diosgenin ( 1 µmol · Positive_regulation WNK1 F2R 19351910 2088754 Here we show that activation *induces* binding of both [p65/RelA] and NFATc1 to the NF-kappaB binding site localized in intron-1 of the ICAM-1 gene to initiate transcription in endothelial cells . Positive_regulation WNK1 IL1B 10644648 661125 These data suggest that constitutive NF-kappaB [p65] protein synthesis is *regulated* by , particularly during pregnancy . Positive_regulation WNK1 IL1B 11912207 944621 Moreover , *activated* the p50 , [p65] , and c-Rel subunits of NF-kappaB/Rel , whereas glutamate activated only the p50 and p65 proteins . Positive_regulation WNK1 IL1B 12055073 951621 treatment did not affect the level of Sp1 but did *induce* translocation of the [p65] subunit of NF-kappaB . Positive_regulation WNK1 IL1B 12193257 981031 We observed that *induced* the degradation of the inhibitor kappaB-alpha protein and the translocation of the protein [p65] ( a member of the nuclear factor-kappaB family ) to the nucleus , which were inhibited by diacerhein and rhein , in a dose dependent manner . Positive_regulation WNK1 IL1B 12890646 1157269 We found that cycloheximide blocked IL-1beta induced downregulation of elastin mRNA but did not inhibit *induced* translocation of [p65] into the nucleus . Positive_regulation WNK1 IL1B 15033982 1251155 This *induced* phosphorylation of [p65] was specifically prevented by pretreatment of EMT-6J cells with the casein kinase II inhibitor DRB . Positive_regulation WNK1 IL1B 15543947 1337757 The selective p50-p50 suppression of IL-1beta gene activation corresponded to the transient nature of [p65-p50] activation *induced* by ( in both HT-29 and Caco-2 cells ) . Positive_regulation WNK1 IL1B 16417227 1514527 Transcription factor ELISAs indicated that the NF-kappaB heterodimer [p50-p65] binds to all three NF-kappaB sites in the hBD-2 promoter upon *stimulation* of primary keratinocytes with and PA . Positive_regulation WNK1 IL1B 16617094 1569136 AS-602868 but not PD-98059 or SP-600125 inhibited [p65] DNA binding *induced* by and TNF-alpha . Positive_regulation WNK1 IL1B 16617094 1569138 By chromatin immunoprecipitation assay , and TNF-alpha *enhanced* [p65] binding to the GRO-alpha promoter , which was inhibited by AS-602868 . Positive_regulation WNK1 IL1B 17335379 1707621 *increased* nuclear and cytoplasmic [p65] ( approximately 8-fold [ P < 0.001 ] and approximately 2.5-fold [ P < 0.03 ] , respectively ) over control levels . Positive_regulation WNK1 IL1B 17349082 1707999 In conclusion , EA inhibits *induced* nuclear translocation of [p65] and p50 , thereby suppressing the expression of VCAM-1 and E-selectin , resulting in decreased monocyte adhesion . Positive_regulation WNK1 IL1B 18314621 1840086 DNA binding avtivity as well as COX-2 mRNA and protein expression were strongly inducible by IL-1beta treatment in OVCAR-3 cells , while p65 siRNA inhibited *dependent* [p65] activity ( p = 0.037 ) as well as COX-2 expression on the mRNA ( p < 0.03 ) and on the protein level . Positive_regulation WNK1 IL1B 19170127 2049004 Concomitant administration of Dex , a known NF-kappaB inhibitor , resulted in significantly down-regulated *induced* [NF-kappaB/p65] activity , as well as reduced expression of chemokine receptors and IL-17F in mouse prostate tissue . Positive_regulation WNK1 IL1B 19171646 2027684 *induced* the phosphorylation and downregulation of IkappaB-alpha as well as the translocation of [p65] to the nucleus . Positive_regulation WNK1 IL1B 19278584 2046334 LSCM graphs showed that *stimulated* the translocation of [p65] from the cytosol to the nucleus . Positive_regulation WNK1 IL1B 19369446 2081691 PD-98059 blocked *induced* phosphorylation of IKK2 , degradation of IkappaB-alpha , and phosphorylation and nuclear translocation of NF-kappaB subunit [p65] , whereas SB-203580 had a marginal effect , implying that the effect of ERK1/2 is exerted on the canonical IKK2/IkappaB-alpha/p65 pathway of NF-kappaB activation but that the effect of p38 MAPK may not predominantly involve NF-kappaB signaling . Positive_regulation WNK1 IL1B 19843519 2170098 Histone deacetylase-1 is enriched at the platelet derived growth factor-D promoter in *response* to and forms a cytokine-inducible gene silencing complex with NF-kappab [p65] and interferon regulatory factor-1 . Positive_regulation WNK1 IL1B 19843519 2170103 NF-kappaB [p65] , *induced* by , interacts with a novel element in the PDGF-D promoter and inhibits PDGF-D transcription . Positive_regulation WNK1 IL1B 20432452 2268149 Moreover , *stimulated* NF-kappaB [p65] translocation was blocked by helenalin , but not by U0126 or SP600125 , revealing that MAPKs and NF-kappaB pathways were independent on these responses . Positive_regulation WNK1 IL1B 9041934 416034 rapidly *stimulated* the translocation of the [p65] , p50 , and c-rel NF-kappa B subunits from the cytoplasm to the nucleus . Positive_regulation WNK1 IL1B 9633934 513208 In contrast to TPCK , which blocked NF-kappaB translocation to the nucleus , norLeu had no effect on NF-kappaB nuclear translocation or *induced* phosphorylation of [p65] . Positive_regulation WNK1 IL1B 9662438 518270 In C127-hIL-1RI cells , signalled through the hIL-1RI and *activated* both [p65/p65] and p50/p65 NFkappaB complexes , where only the activation of NFkappaB p65/p65 was dependent on mIL-1RAcP . Positive_regulation WNK1 NEDD9 8414497 233954 These results suggest that , in this model system , acts as an I kappa B to sequester p50 and p65 in the cytoplasm and that Tax by inhibiting I kappa B activity of p105 , *enhances* nuclear localization of p50 and [p65] . Positive_regulation WNK1 OSR1 16832045 1587594 exists in a complex with WNK1 in cells , is *activated* by recombinant [WNK1] in vitro , and is phosphorylated in a WNK1 dependent manner in cells . Positive_regulation WNK1 PLAU 22797919 2706088 Taken together , these data suggest that PKD2 and PKD3 coordinate to promote prostate cancer cell invasion through [p65] NF-?B- and HDAC1 mediated expression and *activation* of . Positive_regulation WNK1 S100B 15312903 1285299 potently *activates* [p65/c-Rel] transcriptional complexes in hippocampal neurons : Clinical implications for the role of S100B in excitotoxic brain injury . Positive_regulation WNK1 S100B 15312903 1285302 Our data suggest that secreted during the glial response to brain injury potently *activates* [p65/c-Rel] in a RAGE dependent manner and may exert neuroprotective and neuroregenerative effects in psychiatric disorders . Positive_regulation WNK1 TLR7 20629663 2304566 Further investigation demonstrated that these ligands could *trigger* the nuclear translocation of NF-kappaB [p65] and the activated NF-kappaB was sufficient to increase the expression of IL6 transcript in MM cells . Positive_regulation WNK1 TNF 10391896 626785 We show here that expression of Par-4 inhibits the *induced* nuclear translocation of [p65] as well as the kappaB dependent promoter activity . Positive_regulation WNK1 TNF 10438843 635058 is the major *inducer* of NF-kappaB and particularly of the [p50-p65] complex , whereas IL-7 acts as a cofactor by sustaining the expression of the p75 TNF receptor . Positive_regulation WNK1 TNF 10938077 737438 A CKII inhibitor ( PD144795 ) inhibited *induced* [p65] phosphorylation in vivo . Positive_regulation WNK1 TNF 10976991 729655 Western blot and immunocytochemical analyses showed that Dex attenuated the *induced* nuclear translocation of [p65] . Positive_regulation WNK1 TNF 11028545 739576 Incubation of cells in the NF-kappaB inhibitor PSI-I blocked LPS and induced inhibition of apoptosis ( P < 0.05 ) and the *induction* of both nuclear [p65] and TRAF-1 mRNA . Positive_regulation WNK1 TNF 11327828 807821 This inhibition was reversed by addition of the denitrosylating agent dithiothreitol to cellular extracts , whereas NO bioactivity did not affect the *induced* degradation of IkappaBalpha or the nuclear translocation of [p65] . Positive_regulation WNK1 TNF 11450703 836643 Treatment with proteasome inhibitors inhibited the degradation of both IkappaB-alpha and IkappaB-beta and prevented the *dependent* nuclear translocation of [p65] . Positive_regulation WNK1 TNF 11474119 766079 H2O2 inhibited *induced* accumulation of [p65] in the nucleus , although it had no effect on degradation of the IkappaB in cytoplasm . Positive_regulation WNK1 TNF 11799112 922264 PTEN failed to block *induced* IKK activation , IkappaBalpha degradation , p105 processing , [p65] ( RelA ) nuclear translocation , and DNA binding of NF-kappaB . Positive_regulation WNK1 TNF 11983688 954131 Moreover , DHMEQ inhibited the *induced* nuclear accumulation of [p65] , a component of NF-kappaB . Positive_regulation WNK1 TNF 12210742 984106 Binding of NFkappaB [p65] to the MUC1 kappaB site was *induced* by treatment , as demonstrated by electrophoretic mobility shift assay . Positive_regulation WNK1 TNF 12444159 1017403 When examined for the mechanism , we found that piceatannol inhibited *induced* IkappaBalpha phosphorylation , [p65] phosphorylation , p65 nuclear translocation , and IkappaBalpha kinase activation , but had no significant effect on IkappaBalpha degradation . Positive_regulation WNK1 TNF 12471036 1055490 We found basal binding of p300 , p50/p65 NF-kappaB , cyclic AMP regulatory element binding protein-2 , CCAAT/enhancer binding protein beta , and c-Jun. [p50/p65] and p300 binding was selectively *increased* by . Positive_regulation WNK1 TNF 12559944 1052704 Moreover , *induced* phosphorylation of [p65] was severely impaired in S276A mutant , indicating that S276 is the major phosphorylation site of p65 and its phosphorylation is essential for p65 dependent cellular responses . Positive_regulation WNK1 TNF 12692090 1093270 Only at high concentrations , cPG enhanced TNF-alpha induced cell death and inhibited *induced* IkappaB-alpha kinase (IKK) activation , IkappaB-alpha degradation , and [NF-kappaB/p65] translocation , while promoting AP-1/c-jun phosphorylation . Positive_regulation WNK1 TNF 12716675 1083751 The nuclear appearance of p50-NFkappaB and [p65-NFkappaB] acutely *induced* by was not modified by resveratrol but was increased after overnight incubation with resveratrol alone or in combination with TNF-alpha . Positive_regulation WNK1 TNF 12716748 1083763 *induced* inhibitor of kappaB ( IkappaB ) degradation and [p65] translocation from cytoplasm to nuclei in MIN6N8 insulinoma cells . Positive_regulation WNK1 TNF 12859951 1111001 Electrophoretic mobility shift assays showed that *induced* [p65] binding to a potential NF-kappaB binding site at -460/-451 . Positive_regulation WNK1 TNF 14711835 1225530 PTD-p65-P1 had no effect on TNF induced inhibitory subunit of NF-kappaB ( IkappaBalpha ) phosphorylation , IkappaBalpha degradation , or IkappaBalpha kinase activation , but it blocked *induced* [p65] phosphorylation and nuclear translocation . Positive_regulation WNK1 TNF 14749357 1226349 rapidly *increased* [p65] in OV3121-1 nuclei when compared with controls not treated with TNF . Positive_regulation WNK1 TNF 15005855 1217521 EMSA revealed that this site binds with NF-kappaB containing [p65] that was *activated* by Ion/PMA and and that CnI inhibited only Ion/PMA dependent NF-kappaB activation . Positive_regulation WNK1 TNF 15161907 1273349 In addition , mangiferin inhibits *induced* [p65] phosphorylation as well as translocation to the nucleus and also inhibits NF-kappaB activation induced by other inflammatory agents like PMA , ceramide , and SA-LPS . Positive_regulation WNK1 TNF 15192014 1295263 Here we show that *induces* greater ERK dependent [p65] phosphorylation at S536 in transformation sensitive ( P+ ) cells than in P- cells . Positive_regulation WNK1 TNF 15637292 1381266 *dependent* [p65] activation was temporally associated with PKAc/IkappaBalpha complex formation . Positive_regulation WNK1 TNF 15833743 1418008 Tpl2 transduced signals instead *promote* the phosphorylation of [p65] at Ser276 and modulate the spectrum of proteins associated with p65 . Positive_regulation WNK1 TNF 16051251 1525209 Statin treatment of cells abrogated *induced* Akt phosphorylation and [p65] nuclear translocation . Positive_regulation WNK1 TNF 16051251 1525213 As observed with statins , inhibition of PI3-kinase activity by Ly294002 also blocked *induced* [p65] translocation , but did not prevent IkappaBalpha phosphorylation nor IkappaBalpha degradation . Positive_regulation WNK1 TNF 16123045 1467030 stimulation *induced* IKKbeta dependent [p65] nuclear translocation , mucus synthesis , and production of cytokines from epithelial cells . Positive_regulation WNK1 TNF 16322332 1487935 *caused* a significant increase in phosphorylated [p65] levels ( 183 +/- 13.8 % of basal ) while calcium sensing receptor (CaR) agonists exerted a significant inhibition ( 19.2 +/- 3.3 % of basal ) . Positive_regulation WNK1 TNF 16377638 1526970 We also found that SAHA had no effect on direct binding of NF-kappaB to the DNA but inhibited sequentially the *induced* activation of IkappaBalpha kinase , IkappaBalpha phosphorylation , IkappaBalpha ubiquitination , IkappaBalpha degradation , p65 phosphorylation , and [p65] nuclear translocation . Positive_regulation WNK1 TNF 16617094 1569135 AS-602868 but not PD-98059 or SP-600125 inhibited [p65] DNA binding *induced* by IL-1beta and . Positive_regulation WNK1 TNF 16617094 1569137 By chromatin immunoprecipitation assay , IL-1beta and *enhanced* [p65] binding to the GRO-alpha promoter , which was inhibited by AS-602868 . Positive_regulation WNK1 TNF 16624823 1569384 The suppression of NF-kappaB activation correlated with sequential inhibition of the *induced* activation of IkappaBalpha kinase , IkappaBalpha phosphorylation , IkappaBalpha degradation , [p65] phosphorylation , p65 nuclear translocation , and the NF-kappaB dependent reporter gene expression activated by TNF , TNFR1 , TRAF2 , NIK , IKK-beta , and the p65 subunit of NF-kappaB . Positive_regulation WNK1 TNF 16785565 1577147 Furthermore , in tolerant cells , *induced* NF-kappaB [p65] phosphorylation was markedly decreased , which was accompanied by the formation of C/EBPbeta-p65 complexes . Positive_regulation WNK1 TNF 17085785 1643950 In the present study , we demonstrate that activates NF-kappaB activity in neuronal , SH-SY5Y , cells and preferentially *enhances* the binding of p50 and [p65] to the promoter/enhancer regions of the MnSOD gene . Positive_regulation WNK1 TNF 17110449 1732112 Celastrol was found to inhibit the *induced* activation of IkappaBalpha kinase , IkappaBalpha phosphorylation , IkappaBalpha degradation , [p65] nuclear translocation and phosphorylation , and NF-kappaB mediated reporter gene expression . Positive_regulation WNK1 TNF 17126899 1677683 Pre treating ECs with NACOS inhibited the *induced* [p65] and p50 mRNA expressions . Positive_regulation WNK1 TNF 17142966 1653798 stimulation *induced* the biphasic increases in expression of [NFkappaB-p65] , ST3Gal I , FUT IV , ST3Gal IV and ST6GalNAc III mRNAs and the transient increase in expression of ST6Gal I mRNA and the decrease in ST3GalNAc IV mRNA . Positive_regulation WNK1 TNF 17203472 1688868 Systemic and LPS administration activated microglia and *increased* expression of brain pro-inflammatory factors ( i.e. , TNFalpha , MCP-1 , IL-1beta , and NF-kappaB [p65] ) in wild-type mice , but not in TNF R1/R2 ( -/- ) mice . Positive_regulation WNK1 TNF 17390058 1716112 We found that treatment of MCF-7 with 1 microM pitavastatin inhibited the proliferation and suppressed the nuclear expression of NF-kappaB [p65] *induced* by with Western blotting . Positive_regulation WNK1 TNF 17523016 1746070 Furthermore , Western blotting analysis revealed that pretreatment of hyperthermia attenuated *induced* translocation of [p65] into the nuclei of HAEC . Positive_regulation WNK1 TNF 17641059 1771328 Further investigation revealed that *induced* I kappaB alpha kinase activation , I kappaB alpha phosphorylation , I kappaB alpha degradation , and [p65] nuclear translocation were all suppressed in MKK4-KO cells . Positive_regulation WNK1 TNF 17675290 1794078 By electrophoretic mobility shift assay analyses , and lipopolysaccharide *induce* strong p65/p50 and [p65/c-Rel] heterodimer binding to both NF-kappaB and TF-kappaB probes . Positive_regulation WNK1 TNF 17678632 1781208 Interestingly , the latter is mediated by HO-1 , which presumably blocks the *induced* nuclear translocation of NF-kappaB [p65] without affecting I-kappaBalpha degradation . Positive_regulation WNK1 TNF 17827743 1791587 Cornuside treatment attenuated *induced* nuclear factor-kappa B (NF-kappaB) [p65] translocation in HUVECs . Positive_regulation WNK1 TNF 18056447 1833657 Furthermore , treatment slightly *induced* [p65] phosphorylation , and both unphosphorylated and phosphorylated p65 translocated into the nucleus . Positive_regulation WNK1 TNF 18235000 1864347 *induced* the phosphorylation and downregulation of IkappaB-alpha and the translocation of the [p65] subunit of NF-kappaB to the nucleus . Positive_regulation WNK1 TNF 18258304 1884808 this was accompanied by an ablation of *induced* [p65] phosphorylation at serine 276 . Positive_regulation WNK1 TNF 18439578 1915600 A further analysis indicated that lycopene attenuated *induced* IkappaB phosphorylation , NF-kappaB expression , and NF-kappaB [p65] translocation from cytosol to nucleus . Positive_regulation WNK1 TNF 18463678 1971658 Employing a series of in vitro and in cellulo approaches , we have demonstrated that in primary human keratinocytes ( i ) rapidly *induces* ROS generation , IkappaB degradation , NF-kappaB [p65] nuclear translocation , and ultimately production of inflammatory cytokines ; Positive_regulation WNK1 TNF 18566231 1929572 Pinitol also suppressed the NF-kappaB reporter activity *induced* by , TNFR associated death domain , TNFR associated factor-2 , transforming growth factor-beta activated kinase-1 ( TAK-1 ) /TAK1 binding protein-1 , and IkappaBalpha kinase but not that induced by [p65] . Positive_regulation WNK1 TNF 18600306 1966161 Stimulation of hMSCs with *caused* a [p65] translocation from the cytoplasm to nucleoplasm but did not change the expression profile of MSC markers . Positive_regulation WNK1 TNF 18627520 1992617 We also demonstrate that UV only *induced* phosphorylation of [p65] ( S276 ) , while induced phosphorylation at both Ser276 and 536 sites of p65 . Positive_regulation WNK1 TNF 18636175 1937263 Furthermore , glucosamine inhibited the *induced* phosphorylation of p38MAPK and NF-kappaB [p65] , and the nuclear translocation of NF-kappaB in the cells . Positive_regulation WNK1 TNF 18753141 1980024 Electrophoretic mobility shift showed that *induced* [p65] binding to a potential NF-kappaB binding site at -460/-451 . Positive_regulation WNK1 TNF 18789311 1980747 Interestingly , actin disruption primed [p65] phosphorylation *induced* by and LPS , on Ser ( 276 ) and Ser ( 536 ) , respectively , which suggested actin cytoskeleton could also modulate p65 transactivating activity . Positive_regulation WNK1 TNF 19147572 2026424 We also showed that EGCG prevents *induced* [p65] translocation to the nucleus , confirming that hyperacetylation is critical for NF-kappaB translocation as well as activity . Positive_regulation WNK1 TNF 19151401 2079186 PolyI : C , flagellin , or also *induced* NF-kappaB [p65] protein nuclear translocation . Positive_regulation WNK1 TNF 19383900 2066107 Furthermore , SW480 cells stably transformed with wild-type adenomatous polyposis coli showed decreased beta-catenin protein and increased *induced* [p65] NF-kappaB binding as well as iNOS and Traf1 expression . Positive_regulation WNK1 TNF 19385047 2069262 We demonstrated that p300 physically associated with [p65] rather than Smad4 in the *presence* of both and TGF-beta . Positive_regulation WNK1 TNF 19420112 2106612 *caused* translocation of the [p65] subunit of NF-kappaB to the nucleus , resulting in upregulation of inflammatory markers such as adhesion molecules ICAM-1 and VCAM-1 . Positive_regulation WNK1 TNF 19434061 2096505 Endogenous and *induced* expressions of IL-6 , IL-8 , p38 , [p65] and C/EBP-beta were also downregulated by genistein , showing its anti-inflammatory properties . Positive_regulation WNK1 TNF 19447587 2202591 Furthermore , the production of ROS and the nuclear translocation of NF-kappaB p50 and [p65] *induced* by were dose-dependently suppressed by curcumin pretreatment . Positive_regulation WNK1 TNF 19596777 2122948 While activation of NF-kappaB was essential for heat inactivated S. aureus induced and NO , inhibiting GSK-3beta blocked heat inactivated S. aureus *induced* NF-kappaB [p65] nuclear translocation . Positive_regulation WNK1 TNF 19620837 2131214 treatment *induced* an elevated activated [NFkappaB/p65] , concomitant with induced p21 levels , which resulted in increased sensitivity to gefitinib in PC-9-ZD cells . Positive_regulation WNK1 TNF 19710421 2144804 Sustained expression of prohibitin in intestinal epithelial cells in vitro and in vivo ( prohibitin transgenic mice , PHB TG ) resulted in a marked decrease in *induced* nuclear translocation of the NF-kappaB protein [p65] , NF-kappaB/DNA binding , and NF-kappaB mediated transcriptional activation despite robust IkappaB-alpha phosphorylation and degradation and increased cytosolic p65 . Positive_regulation WNK1 TNF 19711042 2127351 We further showed that only LHDAg but not SHDAg increased the *mediated* nuclear translocation of [p65] . Positive_regulation WNK1 TNF 19763702 2175973 High fat diet increased hepatic levels of SREBP-1c , TLR4 , , and IL-6 protein and mRNA and increased *activation* of [p65NF-kappaB] . Positive_regulation WNK1 TNF 19877072 2160705 In addition , CpdA attenuated the *induced* nuclear translocation and DNA binding of [p65] in RA FLS , via the attenuation of IKK phosphorylation and subsequent IkappaBalpha degradation . Positive_regulation WNK1 TNF 19877072 2160719 In sharp contrast , DEX did not affect *induced* IKK phosphorylation , IkappaBalpha degradation , [p65] nuclear translocation , or MAPK activation in RA FLS . Positive_regulation WNK1 TNF 19959714 2204102 Despite normal IkBalpha degradation and polyubiquitination , FAT10 deficiency impaired *induced* IkBalpha degradation and nuclear translocation of [p65] in RTECs , suggesting defective proteasomal degradation of polyubiquitinated IkBalpha . Positive_regulation WNK1 TNF 20082310 2212586 Stimulation of myoblasts with *activated* IkappaB kinase alpha/beta ( IKKalpha/beta ) , IkappaBalpha phosphorylation , [p65] phosphorylation , and kappaB-luciferase activity . Positive_regulation WNK1 TNF 20130413 2293655 TSA also attenuated constitutive and *dependent* [p65] phosphorylation and nuclear translocation in endometriotic cells . Positive_regulation WNK1 TNF 20138622 2280974 N-acetylcysteine , SP600125 , SB203580 and MPA had no effect on either *induced* IkappaBalpha degradation or [p65] nuclear translocation , but attenuated p65 Ser276 phosphorylation . Positive_regulation WNK1 TNF 20147406 2227471 Further , ORFV024 expression decreased *induced* phosphorylation and nuclear translocation of [NF-kappaB-p65] , phosphorylation , and degradation of IkappaBalpha , and phosphorylation of IkappaB kinase (IKK) subunits IKKalpha and IKKbeta , indicating that ORFV024 functions by inhibiting activation of IKKs , the bottleneck for most NF-kappaB activating stimuli . Positive_regulation WNK1 TNF 20351055 2273280 In our current study , we find that cinnamaldehyde induces p65 glutathionylation and inhibits *induced* [p65] nuclear translocation and ICAM-1 expression within 12 h of treatment . Positive_regulation WNK1 TNF 20367887 2245060 Addition of MA inhibited *induced* IkappaBalpha degradation , [p65] phosphorylation , and nuclear translocation . Positive_regulation WNK1 TNF 20482842 2276174 Pristimerin blocked the *induced* IkappaBalpha phosphorylation , translocation of [p65] , and expression of NF-kappaB regulated genes . Positive_regulation WNK1 TNF 20519138 2289581 In addition , icariin suppressed the secretion of , prostaglandin E2 ( PGE ( 2 ) ) and nitric oxide ( NO ) as well as NF-kappaB [p65] *activation* . Positive_regulation WNK1 TNF 20570709 2285422 In calvarial osteoblasts , medicarpin ( 10 ( -10 ) M ) blocked nuclear factor kappaB (NF-kappaB) signaling assessed by *stimulated* nuclear translocation of [p65] subunit of NF-kappaB . Positive_regulation WNK1 TNF 20607584 2340399 *induced* I?B-a phosphorylation and translocation of NF-?B [p65] subunit into nucleus in endothelial cells were assessed using immunoblot analysis . Positive_regulation WNK1 TNF 20607584 2340400 Rebamipide also suppressed *stimulated* NF-?B [p65] nuclear translocation . Positive_regulation WNK1 TNF 20639461 2418994 a-MSH suppressed [NF-?B/p65] phosphorylation *induced* by as well as IkB-a degradation in a dose dependent manner , as assessed by Western blotting . Positive_regulation WNK1 TNF 20663893 2317039 In the absence of PPAR? ligand , *induced* a physical interaction between nuclear [p65] and PPAR? , as demonstrated by co-immunoprecipitation . Positive_regulation WNK1 TNF 20663893 2317040 Chromatin immunoprecipitation assay revealed that *induced* [p65] binding to the cis acting ?B elements in rat RANTES promoter , whereas disruption of PPAR?· Positive_regulation WNK1 TNF 21071440 2371312 The LTß priming process was not due to an increase in *mediated* nuclear translocation of p65 , [p65] DNA binding , or NF-?B transactivational activity . Positive_regulation WNK1 TNF 21176770 2390952 EMSA and ChIP assays showed that *increased* [p50/p65] binding to this ?B site , which was disrupted by 1,25 ( OH ) 2D3 . Positive_regulation WNK1 TNF 21344491 2415380 Consistently , treatment of HeLa cells with the compound significantly suppressed *induced* activation of Akt and phosphorylation of Ser536 in [RelA/p65] , which is required for transactivation activity . Positive_regulation WNK1 TNF 21383009 2426709 and 3 ) IGFBP-3 negatively regulates *induced* expression of the key NF-?B regulatory molecules I?Ba and [p65-NF-?B] at the post-translational level . Positive_regulation WNK1 TNF 21826646 2599169 We found that the *induced* phosphorylation of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor , alpha ( I?Ba ) and nuclear translocation of [p65] were impaired by AMF-26 in both endothelial cells and cancer cells . Positive_regulation WNK1 TNF 22038897 2513761 We found that CAPE did not inhibit *induced* I?B phosphorylation/degradation or nuclear translocation of [RelA/p65] , but targeted downstream signaling events at the level of transcription factor recruitment to the gene promoter . Positive_regulation WNK1 TNF 22128776 2520072 When isolated rabbit HDL was pre incubated with human coronary artery endothelial cells ( HCAECs ) , prior to stimulation with TNF-a , it was found that HDL from ETC-642 treated rabbits were more effective at inhibiting the *induced* increase in ICAM-1 , VCAM-1 and [p65] than HDL isolated from saline treated rabbits ( p < 0.05 ) . Positive_regulation WNK1 TNF 22213337 2617285 ( 3 ) resveratrol inhibited the *activation* of NF-?B [p65] by or PMA in NCI-H292 cells ; Positive_regulation WNK1 TNF 22275269 2658161 The effect of silibinin on *induced* activation of NF-?B [p65] was also examined . Positive_regulation WNK1 TNF 22275269 2658163 ( iii ) silibinin inhibited the *activation* of NF-?B [p65] by in NCI-H292 cells ; Positive_regulation WNK1 TNF 22592405 2632199 In addition , we demonstrated that , by affecting the nuclear translocation of p65 , ID1 is essential in regulating *induced* [p65] recruitment to its downstream target , the cellular inhibitor of apoptosis protein 2 ( cIAP2 ) promoter . Positive_regulation WNK1 TNF 22616553 2632449 *increased* p-ERK1/2 and NF-?B [p65] levels , with higher levels in allergen exposed ASMC , post-TNF-a stimulation ( P < 0.001 ) . Positive_regulation WNK1 TNF 22751795 2676267 The flavonoid extract attenuated *induced* I?B phosphorylation as well as NF-?B , [p65] and p50 translocation from cytosol to nucleus , through inhibition on TNF-a- and H ( 2 ) O ( 2 ) -induced intracellular reactive oxygen species ( ROS ) production . Positive_regulation WNK1 TNF 22895565 2713530 Interestingly , reduction of MMS22L by siRNAs in cancer cells inhibited the *dependent* activation of [RelA/p65] in the NFKB pathway and expression of its downstream anti-apoptotic molecules such as Bcl-XL and TRAF1 . Positive_regulation WNK1 TNF 23035855 2716430 In addition , the effects of total flavonoids on inflammatory molecule expression of cells were tested by immunohistochemistry staining , showing that *induced* expression of PCNA , NF-?B [p65] , ICAM-1 , and VCAM-1 in VSMCs was dose-dependently suppressed by total flavonoids . Positive_regulation WNK1 TNF 23075766 2710537 The frther sudy idicated that PDTC ( NF-?B inhibitor ) pretreatment attenuated TNF-a induced CD40 expression , and SIRT1 siRNA significantly augmented *induced* acetylated-NF-?B [p65] ( Lys310 ) expression . Positive_regulation WNK1 TNF 23935933 2826762 With regard to their anti-inflammatory mechanism , heat shock and Compound A are both able to reduce *stimulated* I?Ba degradation and NF-?B [p65] nuclear translocation . Positive_regulation WNK1 TNF 24011916 2888132 In cultured synovial fibroblast experiments , the D8F2 induced ubiquitination of TNF receptor associated factor 2 (TRAF2) was examined by immunoprecipitation , and nuclear translocation of [p65 nuclear factor-?B (p65NF-?B)] *mediated* by and D8F2 was analyzed by western blotting . Positive_regulation WNK1 TNF 24011916 2888133 The results from in vitro studies indicated that D8F2 can induce TRAF2 ubiquitination and inhibit the nuclear translocation of [p65NF-?B] *mediated* by . Positive_regulation WNK1 TNF 24039253 2862637 Interestingly , LIMK1 or SSH-1L depletion failed to inhibit *induced* [RelA/p65] nuclear translocation and proinflammatory gene expression . Positive_regulation WNK1 TNF 24067962 2863158 The RING finger ( RF ) domain mutant ICP0 ( ICP0-RF ) lost its ability to inhibit *mediated* NF-?B activation and [p65] nuclear translocation and degrade p50 . Positive_regulation WNK1 TNF 24189030 2890320 Since TNF-a activation of most of these factors is dependent on the NF-?B pathway , this latter was studied in TNF-a activated PK. BS-EAcf inhibited the *induced* phosphorylation and degradation of total I?Ba as well as phosphorylation of NF-?B [p65] . Positive_regulation WNK1 TNF 24345501 2880878 *stimulated* significantly phosphorylation on Ser536 of [NF-?B/p65] , Ser473 of Akt at 5-15 min , and activations of IKK-ß and ERK at 15-30 min. Diosgenin ( 1 µmol · Positive_regulation WNK1 TNF 24348668 2881135 The effect of prunetin on *induced* degradation of I?B and translocation of NF-?B [p65] was investigated by western blot analysis . Positive_regulation WNK1 TNF 24348668 2881137 Prunetin inhibited *induced* degradation of I?B and translocation of NF-?B [p65] . Positive_regulation WNK1 TNF 24574500 2924834 *induced* phosphorylation of [p65-Ser] ( 536 ) , p38 , and c-jun was inhibited , and basal inhibitory p65-Ser ( 468 ) phosphorylation was increased in tolerant cells . Positive_regulation WNK1 TNF 7925300 273469 In HeLa cells as well as in B cells , rapidly *induced* nuclear translocation primarily of [p50-p65] , but not of c-rel . Positive_regulation WNK1 TNF 8702838 376073 Elevated cAMP did not prevent nuclear translocation of p50/p65 and c-Rel/p65 heterodimers , decrease nuclear translocation of p65 , or significantly modify *induced* phosphorylation of [p65] . Positive_regulation WNK1 TNF 9528954 496214 The treatment with the antioxidants 20 mM N-acetyl-L-cysteine (NAC) and 10 microM pyrrolidine dithiocarbamate ( PDTC ) inhibited the dependent *activation* of [p65-p50] heterodimer but not the p50-p50 homodimer , indicating that generation of oxidants is required for the activation of the heterodimer NF-kappaB . Positive_regulation WNK1 TNF 9718198 528182 These results suggest that the rapid activation of NF-kappaB by is mainly due to the nuclear translocation of NF-kappaB pre existing in cytosol , and that the subsequent increase in the expression of p50 and [p65] may *result* in the persistent activation of NF-kappaB during TNF-alpha stimulation . Positive_regulation WNK1 TNFSF10 16112027 1448542 When CM , NES2Y , and primary islet cells were transfected by AdIkappaB ( SA ) 2 , *induced* IkappaB degradation and nuclear translocation of NF-kappaB [p50/p65] were blocked . Positive_regulation WNT1 AXIN2 10937998 720815 When [Wnt] signaling in preadipocytes is *prevented* by overexpression of or dominant negative TCF4 , these cells differentiate into adipocytes . Positive_regulation WNT1 AXIN2 11809808 906687 [Wnt/beta-catenin/Tcf] signaling *induces* the transcription of , a negative regulator of the signaling pathway . Positive_regulation WNT1 AXIN2 11809808 906717 Because many sites of Axin2 expression overlapped with those of several Wnt genes , we tested whether was *induced* by [Wnt] signaling . Positive_regulation WNT1 AXIN2 12569091 1071826 *regulates* [Wnt] signaling through down-regulation of beta-catenin . Positive_regulation WNT1 AXIN2 15899843 1408774 The lack of redundancy between Axin and Axin2 could be due to their different modes of expression : while Axin is expressed ubiquitously , is expressed in tissue- and developmental-stage-specific patterns , and its transcription is *induced* by canonical [Wnt] signaling . Positive_regulation WNT1 AXIN2 19075000 2030678 N-cadherin interacts with and LRP5 to negatively *regulate* [Wnt/beta-catenin] signaling , osteoblast function , and bone formation . Positive_regulation WNT1 AXIN2 19075000 2030772 These data indicate that a previously unrecognized interaction negatively *regulates* [Wnt/beta-catenin] signaling and is critical in the regulation of osteoblast function , bone formation , and bone mass . Positive_regulation WNT1 AXIN2 21555575 2435405 Tissue-specific *roles* of in the inhibition and activation of [Wnt] signaling in the mouse embryo . Positive_regulation WNT1 AXIN2 21555575 2435426 The results indicate that although increased stability of Axin2 leads to a loss of canonical Wnt signaling in most tissues , stabilized *enhances* [Wnt] pathway activity in a specific progenitor population in the late primitive streak . Positive_regulation WNT1 AXIN2 22322943 2592196 We propose that CDC20 mediated degradation of *regulates* [Wnt/ß-catenin] signalling for maximal activity during G1/S . Positive_regulation WNT1 AXIN2 22509369 2584165 *dependent* regulation of [Wnt] is important for various developmental processes and human diseases . Positive_regulation WNT1 AXIN2 22957046 2667751 Differential *role* of RGS domain function in [Wnt] signaling during anteroposterior patterning and maternal axis formation . Positive_regulation WNT1 CCND1 12612606 1063440 [Wnt1] and Wnt5a *induce* expression through ErbB1 transactivation in HC11 mammary epithelial cells . Positive_regulation WNT1 CCND1 24282282 2898689 Endogenous *enhanced* [Wnt] and ES cell gene expression and expanded a prostate stem cell population . Positive_regulation WNT1 CHI3L1 23972995 2836224 We also demonstrate that *activates* macrophage mitogen activated protein kinase , protein kinase B/AKT , and [Wnt/ß-catenin] signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation WNT1 CLU 17634137 1793034 This fusion construct sequestered signaling competent beta-catenin whereby [Wnt] signaling was abrogated , and consequently cytoplasmic protein levels *increased* as demonstrated by immunofluorescence . Positive_regulation WNT1 EPHB2 22385658 2566492 The switch in Smad2 ,3 activity after inactivation of PI3K/Akt requires the *activation* of canonical [Wnt] signaling by , which targets Gsk3ß . Positive_regulation WNT1 F2R 15935773 1415045 Depletion of PAR-1A or *causes* dorsoanterior deficits , reduced Spemann organizer gene expression , and inhibition of canonical [Wnt-beta-catenin] signaling . Positive_regulation WNT1 FOXO1 19737954 2139780 Progesterone induction of DKK1 and *results* in inhibition of [Wnt] signaling in the human endometrium . Positive_regulation WNT1 FZD4 16236168 1483662 It is not known how can *activate* [Wnt/beta-catenin] signaling and what biological role this molecule plays in vivo . Positive_regulation WNT1 FZD4 19020754 1992165 *Activation* of [Wnt] signalling in acute myeloid leukemia by induction of . Positive_regulation WNT1 FZD4 20713528 2312921 as a mediator of ERG oncogene *induced* [WNT] signaling and epithelial-to-mesenchymal transition in human prostate cancer cells . Positive_regulation WNT1 FZD4 20713528 2312935 Taken together , our results provide mechanistic insights to ERG oncogenesis in prostate cancer , involving *activation* of [WNT] signaling through , leading to cancer promoting phenotypic effects , including EMT and loss of cell adhesion . Positive_regulation WNT1 FZD4 21177847 2407792 In HEK293 transfection studies , C45Y , Y58C , and C204R mutants did not bind to Norrin and failed to transduce *mediated* [Wnt/ß-catenin] signaling . Positive_regulation WNT1 FZD4 23444378 2787336 Norrin , the Norrie disease gene product , is also capable of activating [Wnt] signaling *mediated* by the receptor and serves as a BMP antagonist . Positive_regulation WNT1 ID1 19079342 2030872 *activates* Akt mediated [Wnt] signaling and p27 ( Kip1 ) phosphorylation through PTEN inhibition . Positive_regulation WNT1 IL1B 19701245 2157952 Macrophage derived *stimulates* [Wnt] signaling and growth of colon cancer cells : a crosstalk interrupted by vitamin D3 . Positive_regulation WNT1 ITGB2 24175614 2879245 Furthermore , analysis of the Itgb2 ( -/- ) mice showed that is *required* for proper [WNT] signaling regulation in the lung . Positive_regulation WNT1 JAG1 17568183 1815707 [WNT-beta-catenin-TCF/LEF] signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , and DKK1 genes . Positive_regulation WNT1 MMP7 20677010 2311810 Here , we report that hepatocyte growth factor (HGF) induced E-cadherin downregulation and cell scattering are attributed to the activation of [Wnt/beta-catenin] signaling and transcriptional *activation* of matrix metalloproteinase . Positive_regulation WNT1 MSX1 12874124 1114913 Furthermore , electroporation in the chick embryo demonstrates that can *induce* [Wnt1] expression in the diencephalon neuroepithelium and in the lateral ectoderm . Positive_regulation WNT1 MSX1 15691759 1371414 and Pax3 cooperate to *mediate* FGF8 and [WNT] signals during Xenopus neural crest induction . Positive_regulation WNT1 MSX1 19815336 2209318 *induces* the [Wnt] pathway antagonist genes DKK1 , DKK2 , DKK3 , and SFRP1 in neuroblastoma cells , but does not block Wnt3 and Wnt5A signalling to DVL3 . Positive_regulation WNT1 MSX1 19815336 2209326 We show that *induces* the expression of four different [Wnt] pathway inhibitor genes : Dickkopf 1-3 (DKK1-3) and secreted frizzled related protein 1 ( SFRP1 ) , and provide evidence that high expression of two of these genes correlates with good prognosis . Positive_regulation WNT1 NES 20016063 2191458 When wt-FLIP-L is expressed in the cytoplasm by conjugation with exogenous NES ( NES-FLIP-L ) , [Wnt] signaling is not *enhanced* , whereas the increases cytoplasmic beta-catenin as efficiently as wt-FLIP-L. cFLIP-L physically interacts with the reporter plasmid for Wnt signaling , but not with the control plasmid . Positive_regulation WNT1 NRARP 16228014 1489368 These findings reveal that independently *regulates* canonical [Wnt] and Notch signalling by modulating LEF1 and Notch protein turnover , respectively . Positive_regulation WNT1 TNF 16464856 1540987 Remarkably , both IL-6 and maintained and *augmented* the canonical [Wnt] signaling associated with low axin and high low density lipoprotein receptor related protein ( LRD ) , Dishevelled , and beta-catenin levels . Positive_regulation WNT1 TNF 18433704 1900210 Arterial calcification : a *mediated* vascular [Wnt-opathy] . Positive_regulation WNT1 TNF 18433704 1900219 TOPGAL mice exhibit greater beta-galactosidase reporter staining versus TOPGAL siblings in the aorta and coronaries , which indicates enhanced mural [Wnt] signaling in *response* to . Positive_regulation WNT1 TNF 18511911 1922441 These results suggest that macrophage derived *promotes* [Wnt/beta-catenin] signalling through inhibition of GSK3beta , which may contribute to tumour development in the gastric mucosa . Positive_regulation WNT1 TNF 20373866 2238951 Accordingly , it is possible that the *induced* promotion of [Wnt] signaling is a novel protumorigenic mechanism of inflammation in gastric carcinogenesis . Positive_regulation WNT1 TNF 21070778 2382746 Macrophage derived *promotes* [Wnt] signaling in epithelial cells , which contributes to gastric tumorigenesis . Positive_regulation WNT1 TNF 21514273 2428746 Msx2 is required for *induced* canonical [Wnt] signaling in 3T3-L1 preadipocytes . Positive_regulation WNT1 TNF 21514273 2428761 We found that transiently *increased* Msx2 expression as well as the expression of canonical [Wnt] signaling molecules , including Wnt3a , Wnt7a , Wnt7b , Wnt10b , low-density lipoprotein receptor related protein 5 ( LRP5 ) and T-cell factor 1 (TCF1) . Positive_regulation WNT1 TNF 21514273 2428793 Msx2 overexpression alone significantly increased the levels of Wnt3a , Wnt7a , Wnt7b , Wnt10b , LRP5 and TCF1 expression , whereas knockdown of Msx2 using small interfering RNA prevented *induced* expression of [Wnt] signaling molecules . Positive_regulation WNT1 UCA1 24495014 2928339 Up-regulation of *activates* [Wnt] signaling in a Wnt6 dependent manner . Positive_regulation WNT1 WIF1 19496188 2091813 DKK-3 and acted as Wnt-antagonists and tumor suppressors , but hypermethylation of the gene promoter and low mRNA expression *activated* [Wnt] signaling aberrantly and induced the development of HCC . Positive_regulation WNT1 WIF1 20334650 2238157 acts as a Wnt-antagonists and tumor suppressor , but hypermethylation of WIF-1 gene promoter and low expression *activate* [Wnt] signaling aberrantly and induce the development of various human tumors . Positive_regulation WNT1 WIF1 21270055 2387611 Loss of Smad1 transcriptional activation of Wif1 was associated with reduced expression and *increased* [Wnt/ß-catenin] signaling activity in lung epithelia , resulting in specific fetal lung abnormalities . Positive_regulation WNT1 WNT7A 11142678 760529 It was demonstrated that Fz-10 interacts with to *induce* synergistically the expression of [Wnt-responsive] genes , such as Siamois and Xnr3 , in Xenopus animal cap assays . Positive_regulation WNT1 WNT7A 18567805 1929730 binding to Fzd5 was shown to *activate* beta-catenin/canonical [Wnt] signaling and increase cellular proliferation . Positive_regulation WNT10A TNF 11494032 846083 *induced* up-regulation of [WNT10A] in MKN45 cells . Positive_regulation WNT10A TNF 11494032 846084 These results strongly suggest that up-regulation of [WNT10A] *induced* by and H. pylori might play key roles in human gastric cancer through activation of WNT -- beta-catenin -- TCF signaling pathway . Positive_regulation WNT10B TNF 12239602 989643 Human [WNT10B] is moderately expressed in MKN45 and MKN74 cells derived from human gastric cancer , and is *up-regulated* by in MKN45 cells . Positive_regulation WNT10B TNF 16464856 1541001 , but not IL-6 , *activated* [Wnt10b] expression , whereas IL-6 increased the apparent phosphorylation of Dishevelled . Positive_regulation WNT10B TNF 17568183 1815657 IL-6 and *induce* upregulation of WNT5A and [WNT10B] , respectively . Positive_regulation WNT10B TNF 19351711 2094417 , but not IL-6 or resistin , *increased* [Wnt10b] , completely inhibited the normal differentiation of the preadipocytes , and instead induced a proinflammatory and macrophage-like phenotype of the cells . Positive_regulation WNT10B TNF 21514273 2428762 We found that transiently *increased* Msx2 expression as well as the expression of canonical Wnt signaling molecules , including Wnt3a , Wnt7a , Wnt7b , [Wnt10b] , low-density lipoprotein receptor related protein 5 ( LRP5 ) and T-cell factor 1 (TCF1) . Positive_regulation WNT11 AXIN2 10937998 720818 When [Wnt] signaling in preadipocytes is *prevented* by overexpression of or dominant negative TCF4 , these cells differentiate into adipocytes . Positive_regulation WNT11 AXIN2 11809808 906688 [Wnt/beta-catenin/Tcf] signaling *induces* the transcription of , a negative regulator of the signaling pathway . Positive_regulation WNT11 AXIN2 11809808 906718 Because many sites of Axin2 expression overlapped with those of several Wnt genes , we tested whether was *induced* by [Wnt] signaling . Positive_regulation WNT11 AXIN2 12569091 1071828 *regulates* [Wnt] signaling through down-regulation of beta-catenin . Positive_regulation WNT11 AXIN2 15899843 1408776 The lack of redundancy between Axin and Axin2 could be due to their different modes of expression : while Axin is expressed ubiquitously , is expressed in tissue- and developmental-stage-specific patterns , and its transcription is *induced* by canonical [Wnt] signaling . Positive_regulation WNT11 AXIN2 17202189 1680713 [Wnt11/beta-catenin] signaling in both oocytes and early embryos *acts* through LRP6 mediated regulation of . Positive_regulation WNT11 AXIN2 19075000 2030681 N-cadherin interacts with and LRP5 to negatively *regulate* [Wnt/beta-catenin] signaling , osteoblast function , and bone formation . Positive_regulation WNT11 AXIN2 19075000 2030776 These data indicate that a previously unrecognized interaction negatively *regulates* [Wnt/beta-catenin] signaling and is critical in the regulation of osteoblast function , bone formation , and bone mass . Positive_regulation WNT11 AXIN2 21555575 2435406 Tissue-specific *roles* of in the inhibition and activation of [Wnt] signaling in the mouse embryo . Positive_regulation WNT11 AXIN2 21555575 2435427 The results indicate that although increased stability of Axin2 leads to a loss of canonical Wnt signaling in most tissues , stabilized *enhances* [Wnt] pathway activity in a specific progenitor population in the late primitive streak . Positive_regulation WNT11 AXIN2 22322943 2592197 We propose that CDC20 mediated degradation of *regulates* [Wnt/ß-catenin] signalling for maximal activity during G1/S . Positive_regulation WNT11 AXIN2 22509369 2584167 *dependent* regulation of [Wnt] is important for various developmental processes and human diseases . Positive_regulation WNT11 AXIN2 22957046 2667754 Differential *role* of RGS domain function in [Wnt] signaling during anteroposterior patterning and maternal axis formation . Positive_regulation WNT11 CCND1 24282282 2898690 Endogenous *enhanced* [Wnt] and ES cell gene expression and expanded a prostate stem cell population . Positive_regulation WNT11 CHI3L1 23972995 2836225 We also demonstrate that *activates* macrophage mitogen activated protein kinase , protein kinase B/AKT , and [Wnt/ß-catenin] signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation WNT11 CLU 17634137 1793035 This fusion construct sequestered signaling competent beta-catenin whereby [Wnt] signaling was abrogated , and consequently cytoplasmic protein levels *increased* as demonstrated by immunofluorescence . Positive_regulation WNT11 EPHB2 22385658 2566493 The switch in Smad2 ,3 activity after inactivation of PI3K/Akt requires the *activation* of canonical [Wnt] signaling by , which targets Gsk3ß . Positive_regulation WNT11 F2R 15935773 1415047 Depletion of PAR-1A or *causes* dorsoanterior deficits , reduced Spemann organizer gene expression , and inhibition of canonical [Wnt-beta-catenin] signaling . Positive_regulation WNT11 FOXO1 19737954 2139782 Progesterone induction of DKK1 and *results* in inhibition of [Wnt] signaling in the human endometrium . Positive_regulation WNT11 FZD4 16236168 1483663 It is not known how can *activate* [Wnt/beta-catenin] signaling and what biological role this molecule plays in vivo . Positive_regulation WNT11 FZD4 19020754 1992166 *Activation* of [Wnt] signalling in acute myeloid leukemia by induction of . Positive_regulation WNT11 FZD4 20713528 2312922 as a mediator of ERG oncogene *induced* [WNT] signaling and epithelial-to-mesenchymal transition in human prostate cancer cells . Positive_regulation WNT11 FZD4 20713528 2312936 Taken together , our results provide mechanistic insights to ERG oncogenesis in prostate cancer , involving *activation* of [WNT] signaling through , leading to cancer promoting phenotypic effects , including EMT and loss of cell adhesion . Positive_regulation WNT11 FZD4 21177847 2407793 In HEK293 transfection studies , C45Y , Y58C , and C204R mutants did not bind to Norrin and failed to transduce *mediated* [Wnt/ß-catenin] signaling . Positive_regulation WNT11 FZD4 23444378 2787337 Norrin , the Norrie disease gene product , is also capable of activating [Wnt] signaling *mediated* by the receptor and serves as a BMP antagonist . Positive_regulation WNT11 ID1 19079342 2030873 *activates* Akt mediated [Wnt] signaling and p27 ( Kip1 ) phosphorylation through PTEN inhibition . Positive_regulation WNT11 IL1B 19701245 2157953 Macrophage derived *stimulates* [Wnt] signaling and growth of colon cancer cells : a crosstalk interrupted by vitamin D3 . Positive_regulation WNT11 ITGB2 24175614 2879246 Furthermore , analysis of the Itgb2 ( -/- ) mice showed that is *required* for proper [WNT] signaling regulation in the lung . Positive_regulation WNT11 JAG1 17568183 1815710 [WNT-beta-catenin-TCF/LEF] signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , and DKK1 genes . Positive_regulation WNT11 MMP7 20677010 2311811 Here , we report that hepatocyte growth factor (HGF) induced E-cadherin downregulation and cell scattering are attributed to the activation of [Wnt/beta-catenin] signaling and transcriptional *activation* of matrix metalloproteinase . Positive_regulation WNT11 MSX1 15691759 1371416 and Pax3 cooperate to *mediate* FGF8 and [WNT] signals during Xenopus neural crest induction . Positive_regulation WNT11 MSX1 19815336 2209319 *induces* the [Wnt] pathway antagonist genes DKK1 , DKK2 , DKK3 , and SFRP1 in neuroblastoma cells , but does not block Wnt3 and Wnt5A signalling to DVL3 . Positive_regulation WNT11 MSX1 19815336 2209327 We show that *induces* the expression of four different [Wnt] pathway inhibitor genes : Dickkopf 1-3 (DKK1-3) and secreted frizzled related protein 1 ( SFRP1 ) , and provide evidence that high expression of two of these genes correlates with good prognosis . Positive_regulation WNT11 NES 20016063 2191461 When wt-FLIP-L is expressed in the cytoplasm by conjugation with exogenous NES ( NES-FLIP-L ) , [Wnt] signaling is not *enhanced* , whereas the increases cytoplasmic beta-catenin as efficiently as wt-FLIP-L. cFLIP-L physically interacts with the reporter plasmid for Wnt signaling , but not with the control plasmid . Positive_regulation WNT11 NRARP 16228014 1489369 These findings reveal that independently *regulates* canonical [Wnt] and Notch signalling by modulating LEF1 and Notch protein turnover , respectively . Positive_regulation WNT11 TNF 16464856 1540989 Remarkably , both IL-6 and maintained and *augmented* the canonical [Wnt] signaling associated with low axin and high low density lipoprotein receptor related protein ( LRD ) , Dishevelled , and beta-catenin levels . Positive_regulation WNT11 TNF 18433704 1900211 Arterial calcification : a *mediated* vascular [Wnt-opathy] . Positive_regulation WNT11 TNF 18433704 1900220 TOPGAL mice exhibit greater beta-galactosidase reporter staining versus TOPGAL siblings in the aorta and coronaries , which indicates enhanced mural [Wnt] signaling in *response* to . Positive_regulation WNT11 TNF 18511911 1922442 These results suggest that macrophage derived *promotes* [Wnt/beta-catenin] signalling through inhibition of GSK3beta , which may contribute to tumour development in the gastric mucosa . Positive_regulation WNT11 TNF 20373866 2238952 Accordingly , it is possible that the *induced* promotion of [Wnt] signaling is a novel protumorigenic mechanism of inflammation in gastric carcinogenesis . Positive_regulation WNT11 TNF 21070778 2382747 Macrophage derived *promotes* [Wnt] signaling in epithelial cells , which contributes to gastric tumorigenesis . Positive_regulation WNT11 TNF 21514273 2428748 Msx2 is required for *induced* canonical [Wnt] signaling in 3T3-L1 preadipocytes . Positive_regulation WNT11 TNF 21514273 2428763 We found that transiently *increased* Msx2 expression as well as the expression of canonical [Wnt] signaling molecules , including Wnt3a , Wnt7a , Wnt7b , Wnt10b , low-density lipoprotein receptor related protein 5 ( LRP5 ) and T-cell factor 1 (TCF1) . Positive_regulation WNT11 TNF 21514273 2428794 Msx2 overexpression alone significantly increased the levels of Wnt3a , Wnt7a , Wnt7b , Wnt10b , LRP5 and TCF1 expression , whereas knockdown of Msx2 using small interfering RNA prevented *induced* expression of [Wnt] signaling molecules . Positive_regulation WNT11 UCA1 24495014 2928340 Up-regulation of *activates* [Wnt] signaling in a Wnt6 dependent manner . Positive_regulation WNT11 WIF1 19496188 2091815 DKK-3 and acted as Wnt-antagonists and tumor suppressors , but hypermethylation of the gene promoter and low mRNA expression *activated* [Wnt] signaling aberrantly and induced the development of HCC . Positive_regulation WNT11 WIF1 20334650 2238158 acts as a Wnt-antagonists and tumor suppressor , but hypermethylation of WIF-1 gene promoter and low expression *activate* [Wnt] signaling aberrantly and induce the development of various human tumors . Positive_regulation WNT11 WIF1 21270055 2387612 Loss of Smad1 transcriptional activation of Wif1 was associated with reduced expression and *increased* [Wnt/ß-catenin] signaling activity in lung epithelia , resulting in specific fetal lung abnormalities . Positive_regulation WNT11 WNT7A 11142678 760531 It was demonstrated that Fz-10 interacts with to *induce* synergistically the expression of [Wnt-responsive] genes , such as Siamois and Xnr3 , in Xenopus animal cap assays . Positive_regulation WNT11 WNT7A 18567805 1929732 binding to Fzd5 was shown to *activate* beta-catenin/canonical [Wnt] signaling and increase cellular proliferation . Positive_regulation WNT16 AXIN2 10937998 720833 When [Wnt] signaling in preadipocytes is *prevented* by overexpression of or dominant negative TCF4 , these cells differentiate into adipocytes . Positive_regulation WNT16 AXIN2 11809808 906693 [Wnt/beta-catenin/Tcf] signaling *induces* the transcription of , a negative regulator of the signaling pathway . Positive_regulation WNT16 AXIN2 11809808 906723 Because many sites of Axin2 expression overlapped with those of several Wnt genes , we tested whether was *induced* by [Wnt] signaling . Positive_regulation WNT16 AXIN2 12569091 1071838 *regulates* [Wnt] signaling through down-regulation of beta-catenin . Positive_regulation WNT16 AXIN2 15899843 1408786 The lack of redundancy between Axin and Axin2 could be due to their different modes of expression : while Axin is expressed ubiquitously , is expressed in tissue- and developmental-stage-specific patterns , and its transcription is *induced* by canonical [Wnt] signaling . Positive_regulation WNT16 AXIN2 19075000 2030696 N-cadherin interacts with and LRP5 to negatively *regulate* [Wnt/beta-catenin] signaling , osteoblast function , and bone formation . Positive_regulation WNT16 AXIN2 19075000 2030796 These data indicate that a previously unrecognized interaction negatively *regulates* [Wnt/beta-catenin] signaling and is critical in the regulation of osteoblast function , bone formation , and bone mass . Positive_regulation WNT16 AXIN2 21555575 2435411 Tissue-specific *roles* of in the inhibition and activation of [Wnt] signaling in the mouse embryo . Positive_regulation WNT16 AXIN2 21555575 2435432 The results indicate that although increased stability of Axin2 leads to a loss of canonical Wnt signaling in most tissues , stabilized *enhances* [Wnt] pathway activity in a specific progenitor population in the late primitive streak . Positive_regulation WNT16 AXIN2 22322943 2592202 We propose that CDC20 mediated degradation of *regulates* [Wnt/ß-catenin] signalling for maximal activity during G1/S . Positive_regulation WNT16 AXIN2 22509369 2584177 *dependent* regulation of [Wnt] is important for various developmental processes and human diseases . Positive_regulation WNT16 AXIN2 22957046 2667769 Differential *role* of RGS domain function in [Wnt] signaling during anteroposterior patterning and maternal axis formation . Positive_regulation WNT16 CCND1 24282282 2898695 Endogenous *enhanced* [Wnt] and ES cell gene expression and expanded a prostate stem cell population . Positive_regulation WNT16 CHI3L1 23972995 2836230 We also demonstrate that *activates* macrophage mitogen activated protein kinase , protein kinase B/AKT , and [Wnt/ß-catenin] signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation WNT16 CLU 17634137 1793040 This fusion construct sequestered signaling competent beta-catenin whereby [Wnt] signaling was abrogated , and consequently cytoplasmic protein levels *increased* as demonstrated by immunofluorescence . Positive_regulation WNT16 EPHB2 22385658 2566498 The switch in Smad2 ,3 activity after inactivation of PI3K/Akt requires the *activation* of canonical [Wnt] signaling by , which targets Gsk3ß . Positive_regulation WNT16 F2R 15935773 1415057 Depletion of PAR-1A or *causes* dorsoanterior deficits , reduced Spemann organizer gene expression , and inhibition of canonical [Wnt-beta-catenin] signaling . Positive_regulation WNT16 FOXO1 19737954 2139792 Progesterone induction of DKK1 and *results* in inhibition of [Wnt] signaling in the human endometrium . Positive_regulation WNT16 FZD4 16236168 1483668 It is not known how can *activate* [Wnt/beta-catenin] signaling and what biological role this molecule plays in vivo . Positive_regulation WNT16 FZD4 19020754 1992171 *Activation* of [Wnt] signalling in acute myeloid leukemia by induction of . Positive_regulation WNT16 FZD4 20713528 2312927 as a mediator of ERG oncogene *induced* [WNT] signaling and epithelial-to-mesenchymal transition in human prostate cancer cells . Positive_regulation WNT16 FZD4 20713528 2312941 Taken together , our results provide mechanistic insights to ERG oncogenesis in prostate cancer , involving *activation* of [WNT] signaling through , leading to cancer promoting phenotypic effects , including EMT and loss of cell adhesion . Positive_regulation WNT16 FZD4 21177847 2407798 In HEK293 transfection studies , C45Y , Y58C , and C204R mutants did not bind to Norrin and failed to transduce *mediated* [Wnt/ß-catenin] signaling . Positive_regulation WNT16 FZD4 23444378 2787342 Norrin , the Norrie disease gene product , is also capable of activating [Wnt] signaling *mediated* by the receptor and serves as a BMP antagonist . Positive_regulation WNT16 ID1 19079342 2030878 *activates* Akt mediated [Wnt] signaling and p27 ( Kip1 ) phosphorylation through PTEN inhibition . Positive_regulation WNT16 IL1B 19701245 2157958 Macrophage derived *stimulates* [Wnt] signaling and growth of colon cancer cells : a crosstalk interrupted by vitamin D3 . Positive_regulation WNT16 ITGB2 24175614 2879251 Furthermore , analysis of the Itgb2 ( -/- ) mice showed that is *required* for proper [WNT] signaling regulation in the lung . Positive_regulation WNT16 JAG1 17568183 1815725 [WNT-beta-catenin-TCF/LEF] signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , and DKK1 genes . Positive_regulation WNT16 MMP7 20677010 2311816 Here , we report that hepatocyte growth factor (HGF) induced E-cadherin downregulation and cell scattering are attributed to the activation of [Wnt/beta-catenin] signaling and transcriptional *activation* of matrix metalloproteinase . Positive_regulation WNT16 MSX1 15691759 1371426 and Pax3 cooperate to *mediate* FGF8 and [WNT] signals during Xenopus neural crest induction . Positive_regulation WNT16 MSX1 19815336 2209324 *induces* the [Wnt] pathway antagonist genes DKK1 , DKK2 , DKK3 , and SFRP1 in neuroblastoma cells , but does not block Wnt3 and Wnt5A signalling to DVL3 . Positive_regulation WNT16 MSX1 19815336 2209332 We show that *induces* the expression of four different [Wnt] pathway inhibitor genes : Dickkopf 1-3 (DKK1-3) and secreted frizzled related protein 1 ( SFRP1 ) , and provide evidence that high expression of two of these genes correlates with good prognosis . Positive_regulation WNT16 NES 20016063 2191476 When wt-FLIP-L is expressed in the cytoplasm by conjugation with exogenous NES ( NES-FLIP-L ) , [Wnt] signaling is not *enhanced* , whereas the increases cytoplasmic beta-catenin as efficiently as wt-FLIP-L. cFLIP-L physically interacts with the reporter plasmid for Wnt signaling , but not with the control plasmid . Positive_regulation WNT16 NRARP 16228014 1489374 These findings reveal that independently *regulates* canonical [Wnt] and Notch signalling by modulating LEF1 and Notch protein turnover , respectively . Positive_regulation WNT16 TNF 16464856 1540999 Remarkably , both IL-6 and maintained and *augmented* the canonical [Wnt] signaling associated with low axin and high low density lipoprotein receptor related protein ( LRD ) , Dishevelled , and beta-catenin levels . Positive_regulation WNT16 TNF 18433704 1900216 Arterial calcification : a *mediated* vascular [Wnt-opathy] . Positive_regulation WNT16 TNF 18433704 1900225 TOPGAL mice exhibit greater beta-galactosidase reporter staining versus TOPGAL siblings in the aorta and coronaries , which indicates enhanced mural [Wnt] signaling in *response* to . Positive_regulation WNT16 TNF 18511911 1922447 These results suggest that macrophage derived *promotes* [Wnt/beta-catenin] signalling through inhibition of GSK3beta , which may contribute to tumour development in the gastric mucosa . Positive_regulation WNT16 TNF 20373866 2238957 Accordingly , it is possible that the *induced* promotion of [Wnt] signaling is a novel protumorigenic mechanism of inflammation in gastric carcinogenesis . Positive_regulation WNT16 TNF 21070778 2382752 Macrophage derived *promotes* [Wnt] signaling in epithelial cells , which contributes to gastric tumorigenesis . Positive_regulation WNT16 TNF 21514273 2428758 Msx2 is required for *induced* canonical [Wnt] signaling in 3T3-L1 preadipocytes . Positive_regulation WNT16 TNF 21514273 2428769 We found that transiently *increased* Msx2 expression as well as the expression of canonical [Wnt] signaling molecules , including Wnt3a , Wnt7a , Wnt7b , Wnt10b , low-density lipoprotein receptor related protein 5 ( LRP5 ) and T-cell factor 1 (TCF1) . Positive_regulation WNT16 TNF 21514273 2428801 Msx2 overexpression alone significantly increased the levels of Wnt3a , Wnt7a , Wnt7b , Wnt10b , LRP5 and TCF1 expression , whereas knockdown of Msx2 using small interfering RNA prevented *induced* expression of [Wnt] signaling molecules . Positive_regulation WNT16 UCA1 24495014 2928345 Up-regulation of *activates* [Wnt] signaling in a Wnt6 dependent manner . Positive_regulation WNT16 WIF1 19496188 2091825 DKK-3 and acted as Wnt-antagonists and tumor suppressors , but hypermethylation of the gene promoter and low mRNA expression *activated* [Wnt] signaling aberrantly and induced the development of HCC . Positive_regulation WNT16 WIF1 20334650 2238163 acts as a Wnt-antagonists and tumor suppressor , but hypermethylation of WIF-1 gene promoter and low expression *activate* [Wnt] signaling aberrantly and induce the development of various human tumors . Positive_regulation WNT16 WIF1 21270055 2387617 Loss of Smad1 transcriptional activation of Wif1 was associated with reduced expression and *increased* [Wnt/ß-catenin] signaling activity in lung epithelia , resulting in specific fetal lung abnormalities . Positive_regulation WNT16 WNT7A 11142678 760548 It was demonstrated that Fz-10 interacts with to *induce* synergistically the expression of [Wnt-responsive] genes , such as Siamois and Xnr3 , in Xenopus animal cap assays . Positive_regulation WNT16 WNT7A 18567805 1929742 binding to Fzd5 was shown to *activate* beta-catenin/canonical [Wnt] signaling and increase cellular proliferation . Positive_regulation WNT2 AXIN2 10937998 720821 When [Wnt] signaling in preadipocytes is *prevented* by overexpression of or dominant negative TCF4 , these cells differentiate into adipocytes . Positive_regulation WNT2 AXIN2 11809808 906689 [Wnt/beta-catenin/Tcf] signaling *induces* the transcription of , a negative regulator of the signaling pathway . Positive_regulation WNT2 AXIN2 11809808 906719 Because many sites of Axin2 expression overlapped with those of several Wnt genes , we tested whether was *induced* by [Wnt] signaling . Positive_regulation WNT2 AXIN2 12569091 1071830 *regulates* [Wnt] signaling through down-regulation of beta-catenin . Positive_regulation WNT2 AXIN2 15899843 1408778 The lack of redundancy between Axin and Axin2 could be due to their different modes of expression : while Axin is expressed ubiquitously , is expressed in tissue- and developmental-stage-specific patterns , and its transcription is *induced* by canonical [Wnt] signaling . Positive_regulation WNT2 AXIN2 19075000 2030684 N-cadherin interacts with and LRP5 to negatively *regulate* [Wnt/beta-catenin] signaling , osteoblast function , and bone formation . Positive_regulation WNT2 AXIN2 19075000 2030780 These data indicate that a previously unrecognized interaction negatively *regulates* [Wnt/beta-catenin] signaling and is critical in the regulation of osteoblast function , bone formation , and bone mass . Positive_regulation WNT2 AXIN2 21555575 2435407 Tissue-specific *roles* of in the inhibition and activation of [Wnt] signaling in the mouse embryo . Positive_regulation WNT2 AXIN2 21555575 2435428 The results indicate that although increased stability of Axin2 leads to a loss of canonical Wnt signaling in most tissues , stabilized *enhances* [Wnt] pathway activity in a specific progenitor population in the late primitive streak . Positive_regulation WNT2 AXIN2 22322943 2592198 We propose that CDC20 mediated degradation of *regulates* [Wnt/ß-catenin] signalling for maximal activity during G1/S . Positive_regulation WNT2 AXIN2 22509369 2584169 *dependent* regulation of [Wnt] is important for various developmental processes and human diseases . Positive_regulation WNT2 AXIN2 22957046 2667757 Differential *role* of RGS domain function in [Wnt] signaling during anteroposterior patterning and maternal axis formation . Positive_regulation WNT2 CCND1 24282282 2898691 Endogenous *enhanced* [Wnt] and ES cell gene expression and expanded a prostate stem cell population . Positive_regulation WNT2 CHI3L1 23972995 2836226 We also demonstrate that *activates* macrophage mitogen activated protein kinase , protein kinase B/AKT , and [Wnt/ß-catenin] signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation WNT2 CLU 17634137 1793036 This fusion construct sequestered signaling competent beta-catenin whereby [Wnt] signaling was abrogated , and consequently cytoplasmic protein levels *increased* as demonstrated by immunofluorescence . Positive_regulation WNT2 EPHB2 22385658 2566494 The switch in Smad2 ,3 activity after inactivation of PI3K/Akt requires the *activation* of canonical [Wnt] signaling by , which targets Gsk3ß . Positive_regulation WNT2 F2R 15935773 1415049 Depletion of PAR-1A or *causes* dorsoanterior deficits , reduced Spemann organizer gene expression , and inhibition of canonical [Wnt-beta-catenin] signaling . Positive_regulation WNT2 FOXO1 19737954 2139784 Progesterone induction of DKK1 and *results* in inhibition of [Wnt] signaling in the human endometrium . Positive_regulation WNT2 FZD4 16236168 1483664 It is not known how can *activate* [Wnt/beta-catenin] signaling and what biological role this molecule plays in vivo . Positive_regulation WNT2 FZD4 19020754 1992167 *Activation* of [Wnt] signalling in acute myeloid leukemia by induction of . Positive_regulation WNT2 FZD4 20713528 2312923 as a mediator of ERG oncogene *induced* [WNT] signaling and epithelial-to-mesenchymal transition in human prostate cancer cells . Positive_regulation WNT2 FZD4 20713528 2312937 Taken together , our results provide mechanistic insights to ERG oncogenesis in prostate cancer , involving *activation* of [WNT] signaling through , leading to cancer promoting phenotypic effects , including EMT and loss of cell adhesion . Positive_regulation WNT2 FZD4 21177847 2407794 In HEK293 transfection studies , C45Y , Y58C , and C204R mutants did not bind to Norrin and failed to transduce *mediated* [Wnt/ß-catenin] signaling . Positive_regulation WNT2 FZD4 23444378 2787338 Norrin , the Norrie disease gene product , is also capable of activating [Wnt] signaling *mediated* by the receptor and serves as a BMP antagonist . Positive_regulation WNT2 ID1 19079342 2030874 *activates* Akt mediated [Wnt] signaling and p27 ( Kip1 ) phosphorylation through PTEN inhibition . Positive_regulation WNT2 IL1B 19701245 2157954 Macrophage derived *stimulates* [Wnt] signaling and growth of colon cancer cells : a crosstalk interrupted by vitamin D3 . Positive_regulation WNT2 ITGB2 24175614 2879247 Furthermore , analysis of the Itgb2 ( -/- ) mice showed that is *required* for proper [WNT] signaling regulation in the lung . Positive_regulation WNT2 JAG1 17568183 1815713 [WNT-beta-catenin-TCF/LEF] signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , and DKK1 genes . Positive_regulation WNT2 MMP7 20677010 2311812 Here , we report that hepatocyte growth factor (HGF) induced E-cadherin downregulation and cell scattering are attributed to the activation of [Wnt/beta-catenin] signaling and transcriptional *activation* of matrix metalloproteinase . Positive_regulation WNT2 MSX1 15691759 1371418 and Pax3 cooperate to *mediate* FGF8 and [WNT] signals during Xenopus neural crest induction . Positive_regulation WNT2 MSX1 19815336 2209320 *induces* the [Wnt] pathway antagonist genes DKK1 , DKK2 , DKK3 , and SFRP1 in neuroblastoma cells , but does not block Wnt3 and Wnt5A signalling to DVL3 . Positive_regulation WNT2 MSX1 19815336 2209328 We show that *induces* the expression of four different [Wnt] pathway inhibitor genes : Dickkopf 1-3 (DKK1-3) and secreted frizzled related protein 1 ( SFRP1 ) , and provide evidence that high expression of two of these genes correlates with good prognosis . Positive_regulation WNT2 NES 20016063 2191464 When wt-FLIP-L is expressed in the cytoplasm by conjugation with exogenous NES ( NES-FLIP-L ) , [Wnt] signaling is not *enhanced* , whereas the increases cytoplasmic beta-catenin as efficiently as wt-FLIP-L. cFLIP-L physically interacts with the reporter plasmid for Wnt signaling , but not with the control plasmid . Positive_regulation WNT2 NRARP 16228014 1489370 These findings reveal that independently *regulates* canonical [Wnt] and Notch signalling by modulating LEF1 and Notch protein turnover , respectively . Positive_regulation WNT2 TNF 16464856 1540991 Remarkably , both IL-6 and maintained and *augmented* the canonical [Wnt] signaling associated with low axin and high low density lipoprotein receptor related protein ( LRD ) , Dishevelled , and beta-catenin levels . Positive_regulation WNT2 TNF 18433704 1900212 Arterial calcification : a *mediated* vascular [Wnt-opathy] . Positive_regulation WNT2 TNF 18433704 1900221 TOPGAL mice exhibit greater beta-galactosidase reporter staining versus TOPGAL siblings in the aorta and coronaries , which indicates enhanced mural [Wnt] signaling in *response* to . Positive_regulation WNT2 TNF 18511911 1922443 These results suggest that macrophage derived *promotes* [Wnt/beta-catenin] signalling through inhibition of GSK3beta , which may contribute to tumour development in the gastric mucosa . Positive_regulation WNT2 TNF 20373866 2238953 Accordingly , it is possible that the *induced* promotion of [Wnt] signaling is a novel protumorigenic mechanism of inflammation in gastric carcinogenesis . Positive_regulation WNT2 TNF 21070778 2382748 Macrophage derived *promotes* [Wnt] signaling in epithelial cells , which contributes to gastric tumorigenesis . Positive_regulation WNT2 TNF 21514273 2428750 Msx2 is required for *induced* canonical [Wnt] signaling in 3T3-L1 preadipocytes . Positive_regulation WNT2 TNF 21514273 2428764 We found that transiently *increased* Msx2 expression as well as the expression of canonical [Wnt] signaling molecules , including Wnt3a , Wnt7a , Wnt7b , Wnt10b , low-density lipoprotein receptor related protein 5 ( LRP5 ) and T-cell factor 1 (TCF1) . Positive_regulation WNT2 TNF 21514273 2428795 Msx2 overexpression alone significantly increased the levels of Wnt3a , Wnt7a , Wnt7b , Wnt10b , LRP5 and TCF1 expression , whereas knockdown of Msx2 using small interfering RNA prevented *induced* expression of [Wnt] signaling molecules . Positive_regulation WNT2 UCA1 24495014 2928341 Up-regulation of *activates* [Wnt] signaling in a Wnt6 dependent manner . Positive_regulation WNT2 WIF1 19496188 2091817 DKK-3 and acted as Wnt-antagonists and tumor suppressors , but hypermethylation of the gene promoter and low mRNA expression *activated* [Wnt] signaling aberrantly and induced the development of HCC . Positive_regulation WNT2 WIF1 20334650 2238159 acts as a Wnt-antagonists and tumor suppressor , but hypermethylation of WIF-1 gene promoter and low expression *activate* [Wnt] signaling aberrantly and induce the development of various human tumors . Positive_regulation WNT2 WIF1 21270055 2387613 Loss of Smad1 transcriptional activation of Wif1 was associated with reduced expression and *increased* [Wnt/ß-catenin] signaling activity in lung epithelia , resulting in specific fetal lung abnormalities . Positive_regulation WNT2 WNT7A 11142678 760533 It was demonstrated that Fz-10 interacts with to *induce* synergistically the expression of [Wnt-responsive] genes , such as Siamois and Xnr3 , in Xenopus animal cap assays . Positive_regulation WNT2 WNT7A 18567805 1929734 binding to Fzd5 was shown to *activate* beta-catenin/canonical [Wnt] signaling and increase cellular proliferation . Positive_regulation WNT3 AXIN2 10937998 720824 When [Wnt] signaling in preadipocytes is *prevented* by overexpression of or dominant negative TCF4 , these cells differentiate into adipocytes . Positive_regulation WNT3 AXIN2 11809808 906690 [Wnt/beta-catenin/Tcf] signaling *induces* the transcription of , a negative regulator of the signaling pathway . Positive_regulation WNT3 AXIN2 11809808 906720 Because many sites of Axin2 expression overlapped with those of several Wnt genes , we tested whether was *induced* by [Wnt] signaling . Positive_regulation WNT3 AXIN2 12569091 1071832 *regulates* [Wnt] signaling through down-regulation of beta-catenin . Positive_regulation WNT3 AXIN2 15899843 1408780 The lack of redundancy between Axin and Axin2 could be due to their different modes of expression : while Axin is expressed ubiquitously , is expressed in tissue- and developmental-stage-specific patterns , and its transcription is *induced* by canonical [Wnt] signaling . Positive_regulation WNT3 AXIN2 19075000 2030687 N-cadherin interacts with and LRP5 to negatively *regulate* [Wnt/beta-catenin] signaling , osteoblast function , and bone formation . Positive_regulation WNT3 AXIN2 19075000 2030784 These data indicate that a previously unrecognized interaction negatively *regulates* [Wnt/beta-catenin] signaling and is critical in the regulation of osteoblast function , bone formation , and bone mass . Positive_regulation WNT3 AXIN2 21555575 2435408 Tissue-specific *roles* of in the inhibition and activation of [Wnt] signaling in the mouse embryo . Positive_regulation WNT3 AXIN2 21555575 2435429 The results indicate that although increased stability of Axin2 leads to a loss of canonical Wnt signaling in most tissues , stabilized *enhances* [Wnt] pathway activity in a specific progenitor population in the late primitive streak . Positive_regulation WNT3 AXIN2 22322943 2592199 We propose that CDC20 mediated degradation of *regulates* [Wnt/ß-catenin] signalling for maximal activity during G1/S . Positive_regulation WNT3 AXIN2 22509369 2584171 *dependent* regulation of [Wnt] is important for various developmental processes and human diseases . Positive_regulation WNT3 AXIN2 22957046 2667760 Differential *role* of RGS domain function in [Wnt] signaling during anteroposterior patterning and maternal axis formation . Positive_regulation WNT3 CCND1 24282282 2898692 Endogenous *enhanced* [Wnt] and ES cell gene expression and expanded a prostate stem cell population . Positive_regulation WNT3 CHI3L1 23972995 2836227 We also demonstrate that *activates* macrophage mitogen activated protein kinase , protein kinase B/AKT , and [Wnt/ß-catenin] signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation WNT3 CLU 17634137 1793037 This fusion construct sequestered signaling competent beta-catenin whereby [Wnt] signaling was abrogated , and consequently cytoplasmic protein levels *increased* as demonstrated by immunofluorescence . Positive_regulation WNT3 EPHB2 22385658 2566495 The switch in Smad2 ,3 activity after inactivation of PI3K/Akt requires the *activation* of canonical [Wnt] signaling by , which targets Gsk3ß . Positive_regulation WNT3 F2R 15935773 1415051 Depletion of PAR-1A or *causes* dorsoanterior deficits , reduced Spemann organizer gene expression , and inhibition of canonical [Wnt-beta-catenin] signaling . Positive_regulation WNT3 FOXO1 19737954 2139786 Progesterone induction of DKK1 and *results* in inhibition of [Wnt] signaling in the human endometrium . Positive_regulation WNT3 FZD4 16236168 1483665 It is not known how can *activate* [Wnt/beta-catenin] signaling and what biological role this molecule plays in vivo . Positive_regulation WNT3 FZD4 19020754 1992168 *Activation* of [Wnt] signalling in acute myeloid leukemia by induction of . Positive_regulation WNT3 FZD4 20713528 2312924 as a mediator of ERG oncogene *induced* [WNT] signaling and epithelial-to-mesenchymal transition in human prostate cancer cells . Positive_regulation WNT3 FZD4 20713528 2312938 Taken together , our results provide mechanistic insights to ERG oncogenesis in prostate cancer , involving *activation* of [WNT] signaling through , leading to cancer promoting phenotypic effects , including EMT and loss of cell adhesion . Positive_regulation WNT3 FZD4 21177847 2407795 In HEK293 transfection studies , C45Y , Y58C , and C204R mutants did not bind to Norrin and failed to transduce *mediated* [Wnt/ß-catenin] signaling . Positive_regulation WNT3 FZD4 23444378 2787339 Norrin , the Norrie disease gene product , is also capable of activating [Wnt] signaling *mediated* by the receptor and serves as a BMP antagonist . Positive_regulation WNT3 ID1 19079342 2030875 *activates* Akt mediated [Wnt] signaling and p27 ( Kip1 ) phosphorylation through PTEN inhibition . Positive_regulation WNT3 IL1B 19701245 2157955 Macrophage derived *stimulates* [Wnt] signaling and growth of colon cancer cells : a crosstalk interrupted by vitamin D3 . Positive_regulation WNT3 ITGB2 24175614 2879248 Furthermore , analysis of the Itgb2 ( -/- ) mice showed that is *required* for proper [WNT] signaling regulation in the lung . Positive_regulation WNT3 JAG1 17568183 1815716 [WNT-beta-catenin-TCF/LEF] signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , and DKK1 genes . Positive_regulation WNT3 MMP7 20677010 2311813 Here , we report that hepatocyte growth factor (HGF) induced E-cadherin downregulation and cell scattering are attributed to the activation of [Wnt/beta-catenin] signaling and transcriptional *activation* of matrix metalloproteinase . Positive_regulation WNT3 MSX1 15691759 1371420 and Pax3 cooperate to *mediate* FGF8 and [WNT] signals during Xenopus neural crest induction . Positive_regulation WNT3 MSX1 19815336 2209321 *induces* the [Wnt] pathway antagonist genes DKK1 , DKK2 , DKK3 , and SFRP1 in neuroblastoma cells , but does not block Wnt3 and Wnt5A signalling to DVL3 . Positive_regulation WNT3 MSX1 19815336 2209329 We show that *induces* the expression of four different [Wnt] pathway inhibitor genes : Dickkopf 1-3 (DKK1-3) and secreted frizzled related protein 1 ( SFRP1 ) , and provide evidence that high expression of two of these genes correlates with good prognosis . Positive_regulation WNT3 NES 20016063 2191467 When wt-FLIP-L is expressed in the cytoplasm by conjugation with exogenous NES ( NES-FLIP-L ) , [Wnt] signaling is not *enhanced* , whereas the increases cytoplasmic beta-catenin as efficiently as wt-FLIP-L. cFLIP-L physically interacts with the reporter plasmid for Wnt signaling , but not with the control plasmid . Positive_regulation WNT3 NRARP 16228014 1489371 These findings reveal that independently *regulates* canonical [Wnt] and Notch signalling by modulating LEF1 and Notch protein turnover , respectively . Positive_regulation WNT3 TNF 16464856 1540993 Remarkably , both IL-6 and maintained and *augmented* the canonical [Wnt] signaling associated with low axin and high low density lipoprotein receptor related protein ( LRD ) , Dishevelled , and beta-catenin levels . Positive_regulation WNT3 TNF 18433704 1900213 Arterial calcification : a *mediated* vascular [Wnt-opathy] . Positive_regulation WNT3 TNF 18433704 1900222 TOPGAL mice exhibit greater beta-galactosidase reporter staining versus TOPGAL siblings in the aorta and coronaries , which indicates enhanced mural [Wnt] signaling in *response* to . Positive_regulation WNT3 TNF 18511911 1922444 These results suggest that macrophage derived *promotes* [Wnt/beta-catenin] signalling through inhibition of GSK3beta , which may contribute to tumour development in the gastric mucosa . Positive_regulation WNT3 TNF 20373866 2238954 Accordingly , it is possible that the *induced* promotion of [Wnt] signaling is a novel protumorigenic mechanism of inflammation in gastric carcinogenesis . Positive_regulation WNT3 TNF 21070778 2382749 Macrophage derived *promotes* [Wnt] signaling in epithelial cells , which contributes to gastric tumorigenesis . Positive_regulation WNT3 TNF 21514273 2428752 Msx2 is required for *induced* canonical [Wnt] signaling in 3T3-L1 preadipocytes . Positive_regulation WNT3 TNF 21514273 2428765 We found that transiently *increased* Msx2 expression as well as the expression of canonical [Wnt] signaling molecules , including Wnt3a , Wnt7a , Wnt7b , Wnt10b , low-density lipoprotein receptor related protein 5 ( LRP5 ) and T-cell factor 1 (TCF1) . Positive_regulation WNT3 TNF 21514273 2428796 Msx2 overexpression alone significantly increased the levels of Wnt3a , Wnt7a , Wnt7b , Wnt10b , LRP5 and TCF1 expression , whereas knockdown of Msx2 using small interfering RNA prevented *induced* expression of [Wnt] signaling molecules . Positive_regulation WNT3 UCA1 24495014 2928342 Up-regulation of *activates* [Wnt] signaling in a Wnt6 dependent manner . Positive_regulation WNT3 WIF1 19496188 2091819 DKK-3 and acted as Wnt-antagonists and tumor suppressors , but hypermethylation of the gene promoter and low mRNA expression *activated* [Wnt] signaling aberrantly and induced the development of HCC . Positive_regulation WNT3 WIF1 20334650 2238160 acts as a Wnt-antagonists and tumor suppressor , but hypermethylation of WIF-1 gene promoter and low expression *activate* [Wnt] signaling aberrantly and induce the development of various human tumors . Positive_regulation WNT3 WIF1 21270055 2387614 Loss of Smad1 transcriptional activation of Wif1 was associated with reduced expression and *increased* [Wnt/ß-catenin] signaling activity in lung epithelia , resulting in specific fetal lung abnormalities . Positive_regulation WNT3 WNT7A 11142678 760535 It was demonstrated that Fz-10 interacts with to *induce* synergistically the expression of [Wnt-responsive] genes , such as Siamois and Xnr3 , in Xenopus animal cap assays . Positive_regulation WNT3 WNT7A 18567805 1929736 binding to Fzd5 was shown to *activate* beta-catenin/canonical [Wnt] signaling and increase cellular proliferation . Positive_regulation WNT3A AXIN2 10023673 590700 These results suggest that forms a complex with GSK-3beta , beta-catenin , and APC , resulting in the stimulation of the degradation of beta-catenin and that [Wnt-3a] *induces* the dissociation of beta-catenin from the Axin complex and accumulates beta-catenin . Positive_regulation WNT3A AXIN2 22748080 2709979 These data demonstrate that [Wnt3a] activation of the canonical pathway *requires* specific phosphorylation events as well as to assemble very large , Dvl3 based supermolecular complexes ; Positive_regulation WNT3A TNF 18433704 1900218 Recently , we described a novel TNF-alpha regulated Msx2-Wnt osteogenic program that regulates arterial calcification in an animal model of type 2 DM . *induces* the osteogenic bone morphogenetic protein-2 (BMP-2) , Msx2 , [Wnt3a] , and Wnt7a mRNAs and leads to increased aortic calcium accumulation . Positive_regulation WNT4 AXIN2 10937998 720827 When [Wnt] signaling in preadipocytes is *prevented* by overexpression of or dominant negative TCF4 , these cells differentiate into adipocytes . Positive_regulation WNT4 AXIN2 11809808 906691 [Wnt/beta-catenin/Tcf] signaling *induces* the transcription of , a negative regulator of the signaling pathway . Positive_regulation WNT4 AXIN2 11809808 906721 Because many sites of Axin2 expression overlapped with those of several Wnt genes , we tested whether was *induced* by [Wnt] signaling . Positive_regulation WNT4 AXIN2 12569091 1071834 *regulates* [Wnt] signaling through down-regulation of beta-catenin . Positive_regulation WNT4 AXIN2 15899843 1408782 The lack of redundancy between Axin and Axin2 could be due to their different modes of expression : while Axin is expressed ubiquitously , is expressed in tissue- and developmental-stage-specific patterns , and its transcription is *induced* by canonical [Wnt] signaling . Positive_regulation WNT4 AXIN2 19075000 2030690 N-cadherin interacts with and LRP5 to negatively *regulate* [Wnt/beta-catenin] signaling , osteoblast function , and bone formation . Positive_regulation WNT4 AXIN2 19075000 2030788 These data indicate that a previously unrecognized interaction negatively *regulates* [Wnt/beta-catenin] signaling and is critical in the regulation of osteoblast function , bone formation , and bone mass . Positive_regulation WNT4 AXIN2 21555575 2435409 Tissue-specific *roles* of in the inhibition and activation of [Wnt] signaling in the mouse embryo . Positive_regulation WNT4 AXIN2 21555575 2435430 The results indicate that although increased stability of Axin2 leads to a loss of canonical Wnt signaling in most tissues , stabilized *enhances* [Wnt] pathway activity in a specific progenitor population in the late primitive streak . Positive_regulation WNT4 AXIN2 22322943 2592200 We propose that CDC20 mediated degradation of *regulates* [Wnt/ß-catenin] signalling for maximal activity during G1/S . Positive_regulation WNT4 AXIN2 22509369 2584173 *dependent* regulation of [Wnt] is important for various developmental processes and human diseases . Positive_regulation WNT4 AXIN2 22957046 2667763 Differential *role* of RGS domain function in [Wnt] signaling during anteroposterior patterning and maternal axis formation . Positive_regulation WNT4 CCND1 24282282 2898693 Endogenous *enhanced* [Wnt] and ES cell gene expression and expanded a prostate stem cell population . Positive_regulation WNT4 CHI3L1 23972995 2836228 We also demonstrate that *activates* macrophage mitogen activated protein kinase , protein kinase B/AKT , and [Wnt/ß-catenin] signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation WNT4 CLU 17634137 1793038 This fusion construct sequestered signaling competent beta-catenin whereby [Wnt] signaling was abrogated , and consequently cytoplasmic protein levels *increased* as demonstrated by immunofluorescence . Positive_regulation WNT4 EPHB2 22385658 2566496 The switch in Smad2 ,3 activity after inactivation of PI3K/Akt requires the *activation* of canonical [Wnt] signaling by , which targets Gsk3ß . Positive_regulation WNT4 F2R 15935773 1415053 Depletion of PAR-1A or *causes* dorsoanterior deficits , reduced Spemann organizer gene expression , and inhibition of canonical [Wnt-beta-catenin] signaling . Positive_regulation WNT4 FOXO1 19737954 2139788 Progesterone induction of DKK1 and *results* in inhibition of [Wnt] signaling in the human endometrium . Positive_regulation WNT4 FZD4 16236168 1483666 It is not known how can *activate* [Wnt/beta-catenin] signaling and what biological role this molecule plays in vivo . Positive_regulation WNT4 FZD4 19020754 1992169 *Activation* of [Wnt] signalling in acute myeloid leukemia by induction of . Positive_regulation WNT4 FZD4 20713528 2312925 as a mediator of ERG oncogene *induced* [WNT] signaling and epithelial-to-mesenchymal transition in human prostate cancer cells . Positive_regulation WNT4 FZD4 20713528 2312939 Taken together , our results provide mechanistic insights to ERG oncogenesis in prostate cancer , involving *activation* of [WNT] signaling through , leading to cancer promoting phenotypic effects , including EMT and loss of cell adhesion . Positive_regulation WNT4 FZD4 21177847 2407796 In HEK293 transfection studies , C45Y , Y58C , and C204R mutants did not bind to Norrin and failed to transduce *mediated* [Wnt/ß-catenin] signaling . Positive_regulation WNT4 FZD4 23444378 2787340 Norrin , the Norrie disease gene product , is also capable of activating [Wnt] signaling *mediated* by the receptor and serves as a BMP antagonist . Positive_regulation WNT4 ID1 19079342 2030876 *activates* Akt mediated [Wnt] signaling and p27 ( Kip1 ) phosphorylation through PTEN inhibition . Positive_regulation WNT4 IL1B 19701245 2157956 Macrophage derived *stimulates* [Wnt] signaling and growth of colon cancer cells : a crosstalk interrupted by vitamin D3 . Positive_regulation WNT4 ITGB2 24175614 2879249 Furthermore , analysis of the Itgb2 ( -/- ) mice showed that is *required* for proper [WNT] signaling regulation in the lung . Positive_regulation WNT4 JAG1 17568183 1815719 [WNT-beta-catenin-TCF/LEF] signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , and DKK1 genes . Positive_regulation WNT4 JAG1 23560082 2767580 qPCR and RNA in situ hybridization assays reveal that endocardial signaling *regulates* [Wnt4] expression in the atrioventricular canal ( AVC ) endocardium and Bmp2 in the AVC myocardium . Positive_regulation WNT4 JAG1 23560082 2767609 These results demonstrate that signaling in endocardial cells *induces* the expression of [Wnt4] , which subsequently acts as a paracrine factor to upregulate Bmp2 expression in the adjacent AVC myocardium to signal EMT . Positive_regulation WNT4 MMP7 20677010 2311814 Here , we report that hepatocyte growth factor (HGF) induced E-cadherin downregulation and cell scattering are attributed to the activation of [Wnt/beta-catenin] signaling and transcriptional *activation* of matrix metalloproteinase . Positive_regulation WNT4 MSX1 15691759 1371422 and Pax3 cooperate to *mediate* FGF8 and [WNT] signals during Xenopus neural crest induction . Positive_regulation WNT4 MSX1 19815336 2209322 *induces* the [Wnt] pathway antagonist genes DKK1 , DKK2 , DKK3 , and SFRP1 in neuroblastoma cells , but does not block Wnt3 and Wnt5A signalling to DVL3 . Positive_regulation WNT4 MSX1 19815336 2209330 We show that *induces* the expression of four different [Wnt] pathway inhibitor genes : Dickkopf 1-3 (DKK1-3) and secreted frizzled related protein 1 ( SFRP1 ) , and provide evidence that high expression of two of these genes correlates with good prognosis . Positive_regulation WNT4 NES 20016063 2191470 When wt-FLIP-L is expressed in the cytoplasm by conjugation with exogenous NES ( NES-FLIP-L ) , [Wnt] signaling is not *enhanced* , whereas the increases cytoplasmic beta-catenin as efficiently as wt-FLIP-L. cFLIP-L physically interacts with the reporter plasmid for Wnt signaling , but not with the control plasmid . Positive_regulation WNT4 NRARP 16228014 1489372 These findings reveal that independently *regulates* canonical [Wnt] and Notch signalling by modulating LEF1 and Notch protein turnover , respectively . Positive_regulation WNT4 TNF 16464856 1540995 Remarkably , both IL-6 and maintained and *augmented* the canonical [Wnt] signaling associated with low axin and high low density lipoprotein receptor related protein ( LRD ) , Dishevelled , and beta-catenin levels . Positive_regulation WNT4 TNF 18433704 1900214 Arterial calcification : a *mediated* vascular [Wnt-opathy] . Positive_regulation WNT4 TNF 18433704 1900223 TOPGAL mice exhibit greater beta-galactosidase reporter staining versus TOPGAL siblings in the aorta and coronaries , which indicates enhanced mural [Wnt] signaling in *response* to . Positive_regulation WNT4 TNF 18511911 1922445 These results suggest that macrophage derived *promotes* [Wnt/beta-catenin] signalling through inhibition of GSK3beta , which may contribute to tumour development in the gastric mucosa . Positive_regulation WNT4 TNF 20373866 2238955 Accordingly , it is possible that the *induced* promotion of [Wnt] signaling is a novel protumorigenic mechanism of inflammation in gastric carcinogenesis . Positive_regulation WNT4 TNF 21070778 2382750 Macrophage derived *promotes* [Wnt] signaling in epithelial cells , which contributes to gastric tumorigenesis . Positive_regulation WNT4 TNF 21514273 2428754 Msx2 is required for *induced* canonical [Wnt] signaling in 3T3-L1 preadipocytes . Positive_regulation WNT4 TNF 21514273 2428766 We found that transiently *increased* Msx2 expression as well as the expression of canonical [Wnt] signaling molecules , including Wnt3a , Wnt7a , Wnt7b , Wnt10b , low-density lipoprotein receptor related protein 5 ( LRP5 ) and T-cell factor 1 (TCF1) . Positive_regulation WNT4 TNF 21514273 2428797 Msx2 overexpression alone significantly increased the levels of Wnt3a , Wnt7a , Wnt7b , Wnt10b , LRP5 and TCF1 expression , whereas knockdown of Msx2 using small interfering RNA prevented *induced* expression of [Wnt] signaling molecules . Positive_regulation WNT4 UCA1 24495014 2928343 Up-regulation of *activates* [Wnt] signaling in a Wnt6 dependent manner . Positive_regulation WNT4 WIF1 19496188 2091821 DKK-3 and acted as Wnt-antagonists and tumor suppressors , but hypermethylation of the gene promoter and low mRNA expression *activated* [Wnt] signaling aberrantly and induced the development of HCC . Positive_regulation WNT4 WIF1 20334650 2238161 acts as a Wnt-antagonists and tumor suppressor , but hypermethylation of WIF-1 gene promoter and low expression *activate* [Wnt] signaling aberrantly and induce the development of various human tumors . Positive_regulation WNT4 WIF1 21270055 2387615 Loss of Smad1 transcriptional activation of Wif1 was associated with reduced expression and *increased* [Wnt/ß-catenin] signaling activity in lung epithelia , resulting in specific fetal lung abnormalities . Positive_regulation WNT4 WNT7A 11142678 760537 It was demonstrated that Fz-10 interacts with to *induce* synergistically the expression of [Wnt-responsive] genes , such as Siamois and Xnr3 , in Xenopus animal cap assays . Positive_regulation WNT4 WNT7A 18567805 1929738 binding to Fzd5 was shown to *activate* beta-catenin/canonical [Wnt] signaling and increase cellular proliferation . Positive_regulation WNT5A AXIN2 17646398 1775797 Using monolayers of primary rodent embryo fibroblasts , we show here that dishevelled (Dvl) and , two major components of the Wnt signaling pathway are required for centrosome reorientation and that [Wnt5a] is *required* for activation of this pathway . Positive_regulation WNT5A CCND1 12612606 1063441 Wnt1 and [Wnt5a] *induce* expression through ErbB1 transactivation in HC11 mammary epithelial cells . Positive_regulation WNT5A IL1B 24840810 2950971 Furthermore , exogenous [WNT5A] *induced* ( P < .05 ) IL-6 , , MMP2 , MMP9 , and SSP1 mRNA expression in human adipocyte cultures . Positive_regulation WNT5A JAG1 17967789 1826513 Likewise , stimulation of Notch signaling by immobilized *promoted* [Wnt5a] expression in EPCs . Positive_regulation WNT5A TNF 12165812 972980 Expression and regulation of WNT5A and WNT5B in human cancer : *up-regulation* of [WNT5A] by in MKN45 cells and up-regulation of WNT5B by beta-estradiol in MCF-7 cells . Positive_regulation WNT5A TNF 12165812 972982 [WNT5A] , but not WNT5B , was *up-regulated* by in MKN45 cells derived from gastric cancer . Positive_regulation WNT5A TNF 17568183 1815659 IL-6 and *induce* upregulation of [WNT5A] and WNT10B , respectively . Positive_regulation WNT5B TNF 12165812 972981 Expression and regulation of WNT5A and WNT5B in human cancer : up-regulation of WNT5A by in MKN45 cells and *up-regulation* of [WNT5B] by beta-estradiol in MCF-7 cells . Positive_regulation WNT5B TNF 12165812 972983 WNT5A , but not [WNT5B] , was *up-regulated* by in MKN45 cells derived from gastric cancer . Positive_regulation WNT5B WNT7A 17001188 1618137 [Wnt 5b] and 7a were rapidly induced in wounded cornea , and *promoted* proliferation of corneal epithelial cells . Positive_regulation WNT6 AXIN2 10937998 720830 When [Wnt] signaling in preadipocytes is *prevented* by overexpression of or dominant negative TCF4 , these cells differentiate into adipocytes . Positive_regulation WNT6 AXIN2 11809808 906692 [Wnt/beta-catenin/Tcf] signaling *induces* the transcription of , a negative regulator of the signaling pathway . Positive_regulation WNT6 AXIN2 11809808 906722 Because many sites of Axin2 expression overlapped with those of several Wnt genes , we tested whether was *induced* by [Wnt] signaling . Positive_regulation WNT6 AXIN2 12569091 1071836 *regulates* [Wnt] signaling through down-regulation of beta-catenin . Positive_regulation WNT6 AXIN2 15899843 1408784 The lack of redundancy between Axin and Axin2 could be due to their different modes of expression : while Axin is expressed ubiquitously , is expressed in tissue- and developmental-stage-specific patterns , and its transcription is *induced* by canonical [Wnt] signaling . Positive_regulation WNT6 AXIN2 19075000 2030693 N-cadherin interacts with and LRP5 to negatively *regulate* [Wnt/beta-catenin] signaling , osteoblast function , and bone formation . Positive_regulation WNT6 AXIN2 19075000 2030792 These data indicate that a previously unrecognized interaction negatively *regulates* [Wnt/beta-catenin] signaling and is critical in the regulation of osteoblast function , bone formation , and bone mass . Positive_regulation WNT6 AXIN2 21555575 2435410 Tissue-specific *roles* of in the inhibition and activation of [Wnt] signaling in the mouse embryo . Positive_regulation WNT6 AXIN2 21555575 2435431 The results indicate that although increased stability of Axin2 leads to a loss of canonical Wnt signaling in most tissues , stabilized *enhances* [Wnt] pathway activity in a specific progenitor population in the late primitive streak . Positive_regulation WNT6 AXIN2 22322943 2592201 We propose that CDC20 mediated degradation of *regulates* [Wnt/ß-catenin] signalling for maximal activity during G1/S . Positive_regulation WNT6 AXIN2 22509369 2584175 *dependent* regulation of [Wnt] is important for various developmental processes and human diseases . Positive_regulation WNT6 AXIN2 22957046 2667766 Differential *role* of RGS domain function in [Wnt] signaling during anteroposterior patterning and maternal axis formation . Positive_regulation WNT6 CCND1 24282282 2898694 Endogenous *enhanced* [Wnt] and ES cell gene expression and expanded a prostate stem cell population . Positive_regulation WNT6 CHI3L1 23972995 2836229 We also demonstrate that *activates* macrophage mitogen activated protein kinase , protein kinase B/AKT , and [Wnt/ß-catenin] signaling and regulates oxidant injury , apoptosis , pyroptosis , inflammasome activation , antibacterial responses , melanoma metastasis , and TGF-ß1 production via IL-13Ra2 dependent mechanisms . Positive_regulation WNT6 CLU 17634137 1793039 This fusion construct sequestered signaling competent beta-catenin whereby [Wnt] signaling was abrogated , and consequently cytoplasmic protein levels *increased* as demonstrated by immunofluorescence . Positive_regulation WNT6 EPHB2 22385658 2566497 The switch in Smad2 ,3 activity after inactivation of PI3K/Akt requires the *activation* of canonical [Wnt] signaling by , which targets Gsk3ß . Positive_regulation WNT6 F2R 15935773 1415055 Depletion of PAR-1A or *causes* dorsoanterior deficits , reduced Spemann organizer gene expression , and inhibition of canonical [Wnt-beta-catenin] signaling . Positive_regulation WNT6 FOXO1 19737954 2139790 Progesterone induction of DKK1 and *results* in inhibition of [Wnt] signaling in the human endometrium . Positive_regulation WNT6 FZD4 16236168 1483667 It is not known how can *activate* [Wnt/beta-catenin] signaling and what biological role this molecule plays in vivo . Positive_regulation WNT6 FZD4 19020754 1992170 *Activation* of [Wnt] signalling in acute myeloid leukemia by induction of . Positive_regulation WNT6 FZD4 20713528 2312926 as a mediator of ERG oncogene *induced* [WNT] signaling and epithelial-to-mesenchymal transition in human prostate cancer cells . Positive_regulation WNT6 FZD4 20713528 2312940 Taken together , our results provide mechanistic insights to ERG oncogenesis in prostate cancer , involving *activation* of [WNT] signaling through , leading to cancer promoting phenotypic effects , including EMT and loss of cell adhesion . Positive_regulation WNT6 FZD4 21177847 2407797 In HEK293 transfection studies , C45Y , Y58C , and C204R mutants did not bind to Norrin and failed to transduce *mediated* [Wnt/ß-catenin] signaling . Positive_regulation WNT6 FZD4 23444378 2787341 Norrin , the Norrie disease gene product , is also capable of activating [Wnt] signaling *mediated* by the receptor and serves as a BMP antagonist . Positive_regulation WNT6 ID1 19079342 2030877 *activates* Akt mediated [Wnt] signaling and p27 ( Kip1 ) phosphorylation through PTEN inhibition . Positive_regulation WNT6 IL1B 19701245 2157957 Macrophage derived *stimulates* [Wnt] signaling and growth of colon cancer cells : a crosstalk interrupted by vitamin D3 . Positive_regulation WNT6 ITGB2 24175614 2879250 Furthermore , analysis of the Itgb2 ( -/- ) mice showed that is *required* for proper [WNT] signaling regulation in the lung . Positive_regulation WNT6 JAG1 17568183 1815722 [WNT-beta-catenin-TCF/LEF] signaling *induces* upregulation of MYC , CCND1 , WISP1 , FGF20 , and DKK1 genes . Positive_regulation WNT6 MMP7 20677010 2311815 Here , we report that hepatocyte growth factor (HGF) induced E-cadherin downregulation and cell scattering are attributed to the activation of [Wnt/beta-catenin] signaling and transcriptional *activation* of matrix metalloproteinase . Positive_regulation WNT6 MSX1 15691759 1371424 and Pax3 cooperate to *mediate* FGF8 and [WNT] signals during Xenopus neural crest induction . Positive_regulation WNT6 MSX1 19815336 2209323 *induces* the [Wnt] pathway antagonist genes DKK1 , DKK2 , DKK3 , and SFRP1 in neuroblastoma cells , but does not block Wnt3 and Wnt5A signalling to DVL3 . Positive_regulation WNT6 MSX1 19815336 2209331 We show that *induces* the expression of four different [Wnt] pathway inhibitor genes : Dickkopf 1-3 (DKK1-3) and secreted frizzled related protein 1 ( SFRP1 ) , and provide evidence that high expression of two of these genes correlates with good prognosis . Positive_regulation WNT6 NES 20016063 2191473 When wt-FLIP-L is expressed in the cytoplasm by conjugation with exogenous NES ( NES-FLIP-L ) , [Wnt] signaling is not *enhanced* , whereas the increases cytoplasmic beta-catenin as efficiently as wt-FLIP-L. cFLIP-L physically interacts with the reporter plasmid for Wnt signaling , but not with the control plasmid . Positive_regulation WNT6 NRARP 16228014 1489373 These findings reveal that independently *regulates* canonical [Wnt] and Notch signalling by modulating LEF1 and Notch protein turnover , respectively . Positive_regulation WNT6 TNF 16464856 1540997 Remarkably , both IL-6 and maintained and *augmented* the canonical [Wnt] signaling associated with low axin and high low density lipoprotein receptor related protein ( LRD ) , Dishevelled , and beta-catenin levels . Positive_regulation WNT6 TNF 18433704 1900215 Arterial calcification : a *mediated* vascular [Wnt-opathy] . Positive_regulation WNT6 TNF 18433704 1900224 TOPGAL mice exhibit greater beta-galactosidase reporter staining versus TOPGAL siblings in the aorta and coronaries , which indicates enhanced mural [Wnt] signaling in *response* to . Positive_regulation WNT6 TNF 18511911 1922446 These results suggest that macrophage derived *promotes* [Wnt/beta-catenin] signalling through inhibition of GSK3beta , which may contribute to tumour development in the gastric mucosa . Positive_regulation WNT6 TNF 20373866 2238956 Accordingly , it is possible that the *induced* promotion of [Wnt] signaling is a novel protumorigenic mechanism of inflammation in gastric carcinogenesis . Positive_regulation WNT6 TNF 21070778 2382751 Macrophage derived *promotes* [Wnt] signaling in epithelial cells , which contributes to gastric tumorigenesis . Positive_regulation WNT6 TNF 21514273 2428756 Msx2 is required for *induced* canonical [Wnt] signaling in 3T3-L1 preadipocytes . Positive_regulation WNT6 TNF 21514273 2428767 We found that transiently *increased* Msx2 expression as well as the expression of canonical [Wnt] signaling molecules , including Wnt3a , Wnt7a , Wnt7b , Wnt10b , low-density lipoprotein receptor related protein 5 ( LRP5 ) and T-cell factor 1 (TCF1) . Positive_regulation WNT6 TNF 21514273 2428798 Msx2 overexpression alone significantly increased the levels of Wnt3a , Wnt7a , Wnt7b , Wnt10b , LRP5 and TCF1 expression , whereas knockdown of Msx2 using small interfering RNA prevented *induced* expression of [Wnt] signaling molecules . Positive_regulation WNT6 UCA1 24495014 2928344 Up-regulation of *activates* [Wnt] signaling in a Wnt6 dependent manner . Positive_regulation WNT6 WIF1 19496188 2091823 DKK-3 and acted as Wnt-antagonists and tumor suppressors , but hypermethylation of the gene promoter and low mRNA expression *activated* [Wnt] signaling aberrantly and induced the development of HCC . Positive_regulation WNT6 WIF1 20334650 2238162 acts as a Wnt-antagonists and tumor suppressor , but hypermethylation of WIF-1 gene promoter and low expression *activate* [Wnt] signaling aberrantly and induce the development of various human tumors . Positive_regulation WNT6 WIF1 21270055 2387616 Loss of Smad1 transcriptional activation of Wif1 was associated with reduced expression and *increased* [Wnt/ß-catenin] signaling activity in lung epithelia , resulting in specific fetal lung abnormalities . Positive_regulation WNT6 WNT7A 11142678 760539 It was demonstrated that Fz-10 interacts with to *induce* synergistically the expression of [Wnt-responsive] genes , such as Siamois and Xnr3 , in Xenopus animal cap assays . Positive_regulation WNT6 WNT7A 18567805 1929740 binding to Fzd5 was shown to *activate* beta-catenin/canonical [Wnt] signaling and increase cellular proliferation . Positive_regulation WNT7A CDH1 12937339 1135341 [WNT7a] *induces* in lung cancer cells . Positive_regulation WNT7A CTNNB1 15802269 1410455 [Wnt-7a] *induced* the accumulation of and the activation of Rac and beta-catenin , and Rac synergistically induced the transcription of MMP-12 . Positive_regulation WNT7A FGF4 9025066 405820 Exogenous *causes* ectopic [Wnt-7a] expression and induces ectopic Shh . Positive_regulation WNT7A FGFR2 14507786 1145117 We suggest that is *required* for AER differentiation , as well as for En1 and [Wnt7a] expression . Positive_regulation WNT7A FN1 23290138 2725414 *regulates* [Wnt7a] signaling and satellite cell expansion . Positive_regulation WNT7A FZD1 18567805 1929719 However , specific that bind [Wnt7a] and the particular signal transduction pathway each Wnt7a-Fzd pair *activates* have not been identified . Positive_regulation WNT7A FZD10 18567805 1929720 However , specific that bind [Wnt7a] and the particular signal transduction pathway each Wnt7a-Fzd pair *activates* have not been identified . Positive_regulation WNT7A FZD10 18567805 1929746 Conversely , [Wnt7a] signaling *mediated* by induced a noncanonical c-Jun NH2-terminal kinase-responsive pathway . Positive_regulation WNT7A FZD2 18567805 1929721 However , specific that bind [Wnt7a] and the particular signal transduction pathway each Wnt7a-Fzd pair *activates* have not been identified . Positive_regulation WNT7A FZD3 18567805 1929722 However , specific that bind [Wnt7a] and the particular signal transduction pathway each Wnt7a-Fzd pair *activates* have not been identified . Positive_regulation WNT7A FZD4 18567805 1929723 However , specific that bind [Wnt7a] and the particular signal transduction pathway each Wnt7a-Fzd pair *activates* have not been identified . Positive_regulation WNT7A FZD5 18567805 1929724 However , specific that bind [Wnt7a] and the particular signal transduction pathway each Wnt7a-Fzd pair *activates* have not been identified . Positive_regulation WNT7A FZD6 18567805 1929725 However , specific that bind [Wnt7a] and the particular signal transduction pathway each Wnt7a-Fzd pair *activates* have not been identified . Positive_regulation WNT7A FZD7 18567805 1929726 However , specific that bind [Wnt7a] and the particular signal transduction pathway each Wnt7a-Fzd pair *activates* have not been identified . Positive_regulation WNT7A FZD8 18567805 1929727 However , specific that bind [Wnt7a] and the particular signal transduction pathway each Wnt7a-Fzd pair *activates* have not been identified . Positive_regulation WNT7A FZD9 18567805 1929728 However , specific that bind [Wnt7a] and the particular signal transduction pathway each Wnt7a-Fzd pair *activates* have not been identified . Positive_regulation WNT7A LMX1A 7501017 336212 [Wnt7a] , required for normal development of the dorsoventral axis in mouse limbs , can *induce* ectopic expression of in ventral mesoderm . Positive_regulation WNT7A LRP6 15880584 1406206 The data are consistent with the view that [Wnt7a] *acts* through and the canonical Wnt signaling pathway during dorsal and posterior limb development in the mouse . Positive_regulation WNT7A MMP12 15802269 1410456 [Wnt-7a] induced the accumulation of beta-catenin and the activation of Rac and beta-catenin , and Rac synergistically *induced* the transcription of . Positive_regulation WNT7A RAC1 15802269 1410457 [Wnt-7a] induced the accumulation of beta-catenin and the activation of Rac and beta-catenin , and synergistically *induced* the transcription of MMP-12 . Positive_regulation WNT7A RAC2 15802269 1410458 [Wnt-7a] induced the accumulation of beta-catenin and the activation of Rac and beta-catenin , and synergistically *induced* the transcription of MMP-12 . Positive_regulation WNT7A RAC3 15802269 1410459 [Wnt-7a] *induced* the accumulation of beta-catenin and the activation of and beta-catenin , and Rac synergistically induced the transcription of MMP-12 . Positive_regulation WNT7A SHH 22281533 2570446 Further validation revealed that the expression of Bok , FoxA1 , Sox8 and [Wnt7a] was *dependent* upon signaling in the retina and their regulation is under positive and negative controls by Gli2 and Gli3 , respectively . Positive_regulation WNT7A SHH 9025066 405819 Exogenous FGF-4 causes ectopic [Wnt-7a] expression and *induces* ectopic . Positive_regulation WNT7A TCF12 22232518 2569238 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of MMP7 promoter by [WNT7A] was *mediated* by <ß-catenin/TCF> signaling . Positive_regulation WNT7A TCF15 22232518 2569239 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of MMP7 promoter by [WNT7A] was *mediated* by <ß-catenin/TCF> signaling . Positive_regulation WNT7A TCF19 22232518 2569240 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of MMP7 promoter by [WNT7A] was *mediated* by <ß-catenin/TCF> signaling . Positive_regulation WNT7A TCF20 22232518 2569241 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of MMP7 promoter by [WNT7A] was *mediated* by <ß-catenin/TCF> signaling . Positive_regulation WNT7A TCF21 22232518 2569242 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of MMP7 promoter by [WNT7A] was *mediated* by <ß-catenin/TCF> signaling . Positive_regulation WNT7A TCF23 22232518 2569246 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of MMP7 promoter by [WNT7A] was *mediated* by <ß-catenin/TCF> signaling . Positive_regulation WNT7A TCF24 22232518 2569248 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of MMP7 promoter by [WNT7A] was *mediated* by <ß-catenin/TCF> signaling . Positive_regulation WNT7A TCF25 22232518 2569247 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of MMP7 promoter by [WNT7A] was *mediated* by <ß-catenin/TCF> signaling . Positive_regulation WNT7A TCF3 22232518 2569243 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of MMP7 promoter by [WNT7A] was *mediated* by <ß-catenin/TCF> signaling . Positive_regulation WNT7A TCF4 22232518 2569244 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of MMP7 promoter by [WNT7A] was *mediated* by <ß-catenin/TCF> signaling . Positive_regulation WNT7A TCF7 22232518 2569245 Overexpression of WNT7A stimulated matrix metalloproteinase 7 (MMP7) promoter , and mutation of TCF binding sites in MMP7 promoter confirmed that activation of MMP7 promoter by [WNT7A] was *mediated* by <ß-catenin/TCF> signaling . Positive_regulation WNT7A TNF 21514273 2428768 We found that transiently *increased* Msx2 expression as well as the expression of canonical Wnt signaling molecules , including Wnt3a , [Wnt7a] , Wnt7b , Wnt10b , low-density lipoprotein receptor related protein 5 ( LRP5 ) and T-cell factor 1 (TCF1) . Positive_regulation WNT7A WNT1 11142678 760541 It was demonstrated that Fz-10 interacts with [Wnt-7a] to *induce* synergistically the expression of genes , such as Siamois and Xnr3 , in Xenopus animal cap assays . Positive_regulation WNT7A WNT11 11142678 760542 It was demonstrated that Fz-10 interacts with [Wnt-7a] to *induce* synergistically the expression of genes , such as Siamois and Xnr3 , in Xenopus animal cap assays . Positive_regulation WNT7A WNT16 11142678 760547 It was demonstrated that Fz-10 interacts with [Wnt-7a] to *induce* synergistically the expression of genes , such as Siamois and Xnr3 , in Xenopus animal cap assays . Positive_regulation WNT7A WNT2 11142678 760543 It was demonstrated that Fz-10 interacts with [Wnt-7a] to *induce* synergistically the expression of genes , such as Siamois and Xnr3 , in Xenopus animal cap assays . Positive_regulation WNT7A WNT3 11142678 760544 It was demonstrated that Fz-10 interacts with [Wnt-7a] to *induce* synergistically the expression of genes , such as Siamois and Xnr3 , in Xenopus animal cap assays . Positive_regulation WNT7A WNT4 11142678 760545 It was demonstrated that Fz-10 interacts with [Wnt-7a] to *induce* synergistically the expression of genes , such as Siamois and Xnr3 , in Xenopus animal cap assays . Positive_regulation WNT7A WNT6 11142678 760546 It was demonstrated that Fz-10 interacts with [Wnt-7a] to *induce* synergistically the expression of genes , such as Siamois and Xnr3 , in Xenopus animal cap assays . Positive_regulation WT1 TGM2 17259349 1691268 Knockdown of PDCD4 by RNA interference ( siRNA ) inhibited ATRA induced granulocytic differentiation and reduced expression of key proteins known to be regulated by ATRA , including p27 ( Kip1 ) and DAP5/p97 , and *induced* c-myc and [Wilms' tumor 1] , but did not alter expression of c-jun , p21 ( Waf1/Cip1 ) , and ( TG2 ) . Positive_regulation WTS IL1B 8538168 338642 *enhanced* [wound tensile strength (WTS)] in TB-irradiated mice , while TGF-beta enhanced WTS in HB-irradiated mice . Positive_regulation WWOX TNF 11058590 809694 Induction of mitochondrial permeability transition by , staurosporine , and atractyloside *resulted* in [WOX1] release from mitochondria and subsequent nuclear translocation . Positive_regulation WWOX TNF 11058590 809695 *mediated* [WOX1] nuclear translocation occurred shortly after that of nuclear factor-kappaB nuclear translocation , whereas both were independent events . Positive_regulation WWOX TNF 17567906 1763223 In *response* to , Zfra is upregulated and modulates TNF mediated cell death via interacting with TRADD , FADD and RIP ( death inducing signaling complex ) at the receptor level , and downstream effectors NF-kappaB , p53 , [WOX1] , and JNK1 . Positive_regulation XAF1 EPHB2 23323858 2753003 We found that activation of *resulted* in a decrease in [XAF1] [ XIAP ( X-linked inhibitor of apoptosis ) -associated factor 1 ] which reduced the formation of the XIAP-XAF1 E3 ligase complex to ubiquitinate survivin . Positive_regulation XBP1 FOXA1 24512546 2914470 Moreover , the expression of [XBP1] , MYC , ZBTB16 , and UHRF1 , which are downstream targets of AR , was *promoted* by up-regulation or inhibited by FOXA1 down-regulation . Positive_regulation XBP1 MAP2K6 21892182 2491632 Further , we show that activation of p38 MAPK by expression of constitutively active ( MKK6Glu ) greatly *enhances* nuclear translocation of [Xbp1s] , reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice . Positive_regulation XBP1 RNASE1 24812669 2939881 Because [XBP-1] expression *requires* the activity of the ER transmembrane receptor IRE-1 , we developed a potent IRE-1 RNase inhibitor through chemical synthesis and modified the structure to facilitate entry into cells to target the IRE-1/XBP-1 pathway . Positive_regulation XBP1 RNASE7 24812669 2939889 Because [XBP-1] expression *requires* the activity of the ER transmembrane receptor IRE-1 , we developed a potent IRE-1 RNase inhibitor through chemical synthesis and modified the structure to facilitate entry into cells to target the IRE-1/XBP-1 pathway . Positive_regulation XBP1 TLR7 20351694 2244934 Instead , *activated* [XBP1] was required for optimal and sustained production of proinflammatory cytokines in macrophages . Positive_regulation XCL1 TNF 15817686 1397500 We also quantified the effects of acute stress on [lymphotactin-] ( LTN ; a predominantly lymphocyte-specific chemokine ) , and ( a proinflammatory cytokine ) *stimulated* leukocyte infiltration . Positive_regulation XDH IL1B 8697004 343296 [Xanthine oxidase] was *stimulated* by but not with HSS and LCGF . Positive_regulation XDH TNF 1544679 183451 Our results suggest that injures brain microvascular EC and that this effect may be *mediated* by [xanthine oxidase] . Positive_regulation XDH TNF 16413574 1520714 *Activation* of JNK and [xanthine oxidase] by impairs nitric oxide mediated dilation of coronary arterioles . Positive_regulation XIAP EPHB2 22554503 2590602 The activation of *increased* [XIAP] expression and led to decreased caspase activation . Positive_regulation XIAP IL1B 11005210 735060 The expression of [XIAP] in HSG cells was *increased* by , TGF-beta1 , or IL-10 . Positive_regulation XIAP MAP2K6 17877640 1796716 In another clone ( PC70 ) , ICP10PK inhibited apoptosis through *dependent* up-regulation of the anti-apoptotic protein [XIAP] ( that inhibits the activity of processed caspase-3 ) and down-regulation of the apoptogenic protein Smac/DIABLO . Positive_regulation XIAP PLAU 18948573 2028763 Indeed , blocking NF-kappaB activation by using specific NF-kappaB inhibitors abolished uPA induced cell survival as it blocked *induced* [XIAP] up-regulation . Positive_regulation XIAP TNF 11159825 781271 Western analysis indicated that alone *increased* the [Xiap] protein level , a response significantly reduced by adenoviral Xiap antisense expression . Positive_regulation XIAP TNF 11565837 863833 On the other hand , [ILP] with cytotoxic drugs alone *induced* only a modest release of , which was not followed by an immediate rise in IL-6 and IL-8 . Positive_regulation XIAP TNF 16154537 1455460 ( iv ) [XIAP] expression was *induced* by through a nuclear factor-kappaB (NF-kappaB) dependent pathway , and interferon (IFN)-gamma prevented such an induction in a manner independent of NF-kappaB , which presents a potential mechanism underlying cytotoxic IFN-gamma/TNF-alpha synergism . Positive_regulation XIAP TNF 16924232 1692192 *induced* the expression of NF-kappaB regulated gene products cyclin D1 , c-Myc , matrix metalloproteinase-9 , survivin , [X-linked inhibitor-of-apoptosis protein] ( IAP ) , IAP1 , Bcl-x ( L ) , A1/Bfl-1 and Fas associated death domain protein-like IL-1beta converting enzyme-inhibitory protein in wild-type MEF but not in PKR-/- cells . Positive_regulation XIAP TNF 17133355 1677746 In human endothelial cells , *induced* c-IAP1 and c-IAP2 , but not [XIAP] and TIAP/Survivin , at the transcriptional level . Positive_regulation XIAP TNF 17349210 1708025 Furthermore , *up-regulated* [X-linked inhibitor of apoptosis protein] ( XIAP ) transiently and XIAP levels were correlated with the temporal pattern of TNF-alpha protection against Fas mediated apoptosis . Positive_regulation XIAP TNF 17620422 1798297 The *induction* of [X-linked inhibitor of apoptosis protein] by was inhibited by IFN-gamma in STAT1 ( +/- ) islet cells but not in STAT1 ( -/- ) islet cells . Positive_regulation XIAP TNF 17942934 1814224 The *induction* of various antiapoptotic gene products ( MMP-9 , cyclin D1 , COX-2 , IAP1 , IAP2 , Bcl-2 , cFLIP , and [XIAP] ) by was also abolished in NQO2-/- cells . Positive_regulation XIAP TNF 18467439 1938872 On the opposite , *up-regulated* [XIAP] in Hec-1A cells ; Positive_regulation XIAP TNF 21820422 2490442 Triptolide also abrogated *induced* expression of cell survival proteins ( [XIAP] , Bcl-x ( L ) , Bcl-2 , survivin , cIAP-1 and cIAP-2 ) , cell proliferative proteins ( cyclin D1 , c-myc and cyclooxygenase-2 ) , and metastasis proteins ( ICAM-1 and MMP-9 ) . Positive_regulation XIAP TNFSF10 15385934 1324188 induced no discernible changes in FLIP , DR4 , DR5 , Mcl-1 , or survivin expression , modest declines in levels of DcR2 and c-IAP , but *resulted* in the marked transcriptional downregulation of [XIAP] . Positive_regulation XIAP TNFSF10 15623604 1349135 Bcl-2 inhibited *induced* Bax translocation , cytosolic release of cytochrome c and Smac/DIABLO , and the downstream cleavage of [XIAP] and DFF45 . Positive_regulation XIAP TNFSF10 16024612 1435243 [XIAP] levels were *increased* by in combination with z-VAD , whereas XIAP levels were decreased by TRAIL alone . Positive_regulation XIAP TNFSF10 16848771 1588410 We conclude that *induced* apoptosis in a subpopulation of chemotherapy-refractory nodal DLBCL and that disruption of the intrinsic apoptosis mediated pathway and expression of Bcl-2 and [XIAP] did not confer resistance to hsTRAIL/Apo2L induced apoptosis in DLBCL . Positive_regulation XIAP TNFSF10 20137126 2208051 *induced* apoptosis in RPMI8226 cells , the expression level of genes bcl-2 , mcl-1 , CARP1 , CARP2 , [XIAP] and cFLIP decreased , while the expression level of Bax increased , but the expression level of caspase-3 and NF-kappaB P65 ( RelA ) proteins decreased . Positive_regulation XPO1 IL1B 20222144 2243574 *increased* [CRM1] expression in concert with a translocation of HMGB1 from nucleus into cytoplasm . Positive_regulation XPO1 NES 12821673 1134482 The Smad1 NES2 mutant but not the Smad1 NES1 mutant is mostly resistant to this cytoplasmic targeting , indicating that , not NES1 , is the major *target* for [CRM1] in Smad1 . Positive_regulation XPO1 NES 15020682 1221559 [CRM1] and Ran are present but a complex is not *required* in Balbiani ring mRNP particles from the gene to the cytoplasm . Positive_regulation XPO1 NES 16705178 1560794 Treatment of cells with leptomycin B ( LMB ) , a specific inhibitor of the *dependent* receptor [CRM1] , causes nuclear accumulation of Dok1 . Positive_regulation XPO1 NES 19525230 2109046 We also show that the Hxk2 nuclear export and the binding of Hxk2 and [Xpo1] *involve* two leucine-rich located between leucine 23 and isoleucine 33 ( NES1 ) and between leucine 310 and leucine 318 ( NES2 ) . Positive_regulation XPO1 NES 23115280 2721460 The interaction between NEP and [CRM1] is coordinately *regulated* by both the previously reported ( NES1 ) and now the new NES2 . Positive_regulation XPO1 STK39 18083840 1836957 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Positive_regulation XPO1 TNF 23950892 2831597 In the presence of TNF , LMB co-treatment led to accumulation of both IL-15Ra and IL-15 in the nucleus of HeLa cells , suggesting that CRM1 facilitates nuclear export and that *enhances* [CRM1] activity . Positive_regulation XRCC1 EGLN3 24477694 2913239 We previously found that hypoxia-inducible factor ( HIF) prolyl hydroxylase-3 (PHD3 ) was frequently overexpressed in renal cell carcinomas ( RCCs ) , unlike in normal tissues , and therefore , we studied the mechanism and *role* of expression in [RCC] . Positive_regulation XRCC1 TGM2 23704086 2833892 However , the key *role* of in [RCC] was not clear . Positive_regulation XRCC5 EPHB2 15178807 1280488 TPA treatment rapidly increased phosphorylation of , a reported downstream effector of both PKC and Rap1 , in ERC-18 cells , but induced weak [Rap1] *activation* . Positive_regulation XRCC5 F2R 15078882 1251874 We found that , similarly to thrombin , selective stimulation of either or PAR-4 by specific activating peptides *caused* accumulation of GTP bound [Rap1B] in a dose dependent manner . Positive_regulation XRCC5 F2R 15078882 1251888 In the presence of the ADP scavengers apyrase or phosphocreatine-phosphocreatine kinase , activation of [Rap1B] *induced* by stimulation of either or PAR-4 was totally inhibited . Positive_regulation XRCC5 F2R 19483102 2107925 Perturbation of PI3K signaling by isoform-selective inhibitors had differential effects on [Rap1] *activation* through and PAR4 . Positive_regulation XRCC5 F2R 24790104 2950502 Stimulation of the G-protein coupled receptor with thrombin in human 1321N1 glioblastoma cells *led* to a robust increase in [Rap1] activation . Positive_regulation XRCC5 TNF 16043520 1437847 Both compounds blocked *induced* activation of [Rap1A] , a phox associated guanosine triphosphatase that is regulated by cAMP . Positive_regulation XRCC5 TNFSF10 22753480 2639463 In contrast , HSP90 inhibition by geldanamycin markedly enhances *induced* [DNA-PK] and H2AX activation . Positive_regulation XRCC6 EPHB2 15178807 1280491 TPA treatment rapidly increased phosphorylation of , a reported downstream effector of both PKC and Rap1 , in ERC-18 cells , but induced weak [Rap1] *activation* . Positive_regulation XRCC6 F2R 15078882 1251880 We found that , similarly to thrombin , selective stimulation of either or PAR-4 by specific activating peptides *caused* accumulation of GTP bound [Rap1B] in a dose dependent manner . Positive_regulation XRCC6 F2R 15078882 1251894 In the presence of the ADP scavengers apyrase or phosphocreatine-phosphocreatine kinase , activation of [Rap1B] *induced* by stimulation of either or PAR-4 was totally inhibited . Positive_regulation XRCC6 F2R 19483102 2107931 Perturbation of PI3K signaling by isoform-selective inhibitors had differential effects on [Rap1] *activation* through and PAR4 . Positive_regulation XRCC6 F2R 24790104 2950505 Stimulation of the G-protein coupled receptor with thrombin in human 1321N1 glioblastoma cells *led* to a robust increase in [Rap1] activation . Positive_regulation XRCC6 TNF 16043520 1437850 Both compounds blocked induced *activation* of [Rap1A] , a phox associated guanosine triphosphatase that is regulated by cAMP . Positive_regulation XRCC6 TNFSF10 22753480 2639464 In contrast , HSP90 inhibition by geldanamycin markedly enhances *induced* [DNA-PK] and H2AX activation . Positive_regulation YAP1 MAP2K6 23857250 2817064 Furthermore , the nuclear activation of [YAP1] in 8505C was not *inhibited* by RAF or inhibitor . Positive_regulation YBX1 EPHB2 23967153 2832639 Grape seed procyanidin reversal of p-glycoprotein associated multi-drug resistance via down-regulation of NF-?B and *mediated* [YB-1] activity in A2780/T cells . Positive_regulation YME1L1 IL1B 20011701 2175190 A [PAMP] such as lipopolysaccharide can *induce* production of intracellular and pro-IL-18 , but not their secretion . Positive_regulation YWHAB EPHB2 12364324 1019126 GLP1 stimulated activation of is blocked by inhibitors of MEK , but GLP1 does not *induce* the activation of A-Raf , [B-Raf] , C-Raf , or Ras . Positive_regulation YWHAB EPHB2 18508762 1939445 The majority of melanoma associated B-Raf mutations involve a single point mutation , V600E , which results in greatly elevated [B-Raf] kinase activity and constitutive *activation* of downstream . Positive_regulation YY1 EPHB2 20457614 2283001 Fentanyl induced beta-arrestin2 mediated phosphorylation *led* to the phosphorylation of [Yin Yang 1 (YY1)] . Positive_regulation YY1 EPHB2 20457614 2283002 In contrast , because morphine induces phosphorylation via the protein kinase C pathway , morphine did not *induce* [YY1] phosphorylation and had no effect on the transcription of talin2 and the cellular content of miR-190 . Positive_regulation YY1 IL1B 10860774 704876 In support of an *induced* post-translational modification of [YY1] that results in an increase in DNA binding activity , ( 32 ) P-labeling experiments reveal an increase in phosphorylated YY1 in IL-1 beta treated cells and phosphatase treated myocyte nuclear proteins lose their ability to bind to the YY1 site . Positive_regulation YY1 TNF 16784892 1599412 Thus , we hypothesized that tumor derived *induces* the activation of NF-kappaB and the transcription repressor [YY1] , both of which negatively regulate Fas expression and sensitivity to FasL induced apoptosis . Positive_regulation YY1 ZFP57 20808772 2313960 Levels of both and PcG proteins inversely correlated with those of reactive oxygen species ( ROS ) in senescing MEFs , but the treatment of Zfp277 ( -/- ) MEFs with an antioxidant *restored* the binding of [PRC2] but not PRC1 to the Ink4a/Arf locus . Positive_regulation ZAP70 EPHB2 15307176 1284829 CD46 enhanced TCR/CD3 induced tyrosine phosphorylation of CD3zeta and [ZAP-70] , as well as the *activation* of the , JNK , and p38 , but did not modify intracellular calcium . Positive_regulation ZAP70 EPHB2 9553143 499550 [ZAP-70] dependent and -independent *activation* of in Jurkat T cells . Positive_regulation ZAP70 EPHB2 9553143 499553 Surprisingly , although ZAP-70 was required for H2O2 mediated Erk activation , activation in response to T cell antigen receptor engagement did not *require* [ZAP-70] . Positive_regulation ZAP70 ITGB2 16002691 1430992 Experiments performed with specific inhibitors revealed that entry of HIV-1 in activated CD4 ( + ) T cells is regulated by *dependent* [ZAP70] , phospholipase Cgamma1 , and calpain enzymatic activities . Positive_regulation ZAP70 ITGB2 9732296 530620 We conclude that engagement *triggers* [ZAP-70] activity that is essential for LFA-1 dependent migration . Positive_regulation ZAP70 TNFSF10 17476690 1772257 Although Zap-70 ( high ) and Zap-70 ( low ) B-CLL samples displayed similar levels of surface death receptor TRAIL-R2 , recombinant *induced* cytotoxicity only in a subset of Zap-70 ( low ) B-CLL samples while [Zap-70] ( high ) were completely resistant to TRAIL . Positive_regulation ZBTB16 EGR2 22306690 2560479 Chromatin immunoprecipitation followed by deep sequencing showed that directly bound and *activated* the promoter of [Zbtb16] , which encodes the NKT lineage-specific transcription factor PLZF . Positive_regulation ZBTB16 FOXA1 24512546 2914471 Moreover , the expression of XBP1 , MYC , [ZBTB16] , and UHRF1 , which are downstream targets of AR , was *promoted* by up-regulation or inhibited by FOXA1 down-regulation . Positive_regulation ZC3H12A IL1B 20137095 2213616 We conclude that the transcription factor Elk-1 plays an important role in the activation of [ZC3H12A] expression in *response* to stimulation . Positive_regulation ZC3H12A TLR7 23422584 2764976 Here we report that although [MCPIP1] was *induced* by various ligands in macrophages , MCPIP1-deficient mice are extremely susceptible to TLR4 ligand ( LPS ) -induced septic shock and death , but not to the TLR2 , 3 , 5 and 9 ligands induced septic shock . Positive_regulation ZC3H12D TLR7 22036805 2527503 In macrophages , the expression of [Zc3h12d] was remarkably *induced* by ligands through JNK and NF-?B signal pathways . Positive_regulation ZC3HAV1 EPHB2 9553143 499551 [ZAP-70 dependent and -independent] *activation* of in Jurkat T cells . Positive_regulation ZC3HAV1 ITGB2 7912151 261941 6. We conclude that oedema formation and haemorrhage associated with RPA reactions and in responses to zymosan and [ZAP] are completely *dependent* , and are mediated , at least in part , via ICAM-1 . Positive_regulation ZDHHC2 BPI 17012258 1629177 , but not control protein thaumatin , activated extracellular regulated kinase (ERK) and AKT , and *increased* DNA synthesis in RPE and RPC but not in [REC] . Positive_regulation ZEB1 PLAU 23340304 2747446 Optimal induction of by Wnt signaling *requires* [ZEB1] expression . Positive_regulation ZFP1 TLR7 23857586 2829819 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP14 TLR7 23857586 2829879 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP2 TLR7 23857586 2829849 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP28 TLR7 23857586 2829789 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP3 TLR7 23857586 2829729 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP30 TLR7 23857586 2829889 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP36 EPHB2 17606294 1842197 Together these data indicate that the proteasome is a critical control point for [TTP] mediated TNF-alpha mRNA decay and activation of both and p38 is *required* to inhibit TTP function and stabilize TNF-alpha mRNA . Positive_regulation ZFP36 IL1B 19435930 2106997 Analysis with IkappaBalphaDeltaN , a dominant version of inhibitor of kappaBalpha ( IkappaBalpha ) , as well as dominant negative and small-molecule IkappaB kinase (IKK) inhibitors demonstrated that *induced* [TTP] is nuclear factor-kappaB (NF-kappaB) dependent . Positive_regulation ZFP36 IL1B 19435930 2106999 Given a requirement for p38 MAPK in the *induction* of [TTP] by , this repressive effect may be explained by repression of the p38 MAPK pathway by dexamethasone . Positive_regulation ZFP36 IL1B 19435930 2107015 Taken together , our data demonstrate that NF-kappaB and p38 MAPK are critical to the *induction* of [TTP] by and that TTP induction provides feedback control of the ARE containing genes GM-CSF and IL-8 . Positive_regulation ZFP36 TLR7 23857586 2829739 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP36 TNF 10763822 683932 [TTP] expression is *induced* by , and evidence indicates that TTP can bind and destabilize the TNF-alpha mRNA . Positive_regulation ZFP36 TNF 11447117 835522 Moreover , IL-10 does not alter mRNA stability , and its action does not *require* the presence of the stability regulating ARE binding factor [tristetraprolin] , indicating a differential assembly of stability and translation determinants on the TNF ARE . Positive_regulation ZFP36 TNF 11588035 866575 In cultured cells derived from these mice , apparent cooperation between the TNFRs was required to achieve normal *induced* expression of [TTP] , TNF-alpha , and GM-CSF mRNAs . Positive_regulation ZFP36 TNF 12823857 1104337 These data establish the cytoplasmic location of TTP , supporting a major role for this protein in regulating TNF production , and suggest that [TTP] levels are not *regulated* solely by . Positive_regulation ZFP36 TNF 15170914 1253745 A low TTP/TNF-a gene expression ratio could indicate failure of RA patients to produce adequate amounts of [TTP] in *response* to increased production . Positive_regulation ZFP36 TNF 18047469 1867321 Post-transcriptional regulation of CLMP mRNA is controlled by [tristetraprolin] in *response* to via c-Jun N-terminal kinase signalling . Positive_regulation ZFP36 TNF 18047469 1867324 Activation of the JNK signalling pathway by *up-regulated* the expression of an RNA binding protein , [TTP] ( tristetraprolin ) . Positive_regulation ZFP36 TNF 19106809 2093294 Confocal microscopy and real-time polymerase chain reaction showed that *induced* intracellular [tristetraprolin (TTP)] expression . Positive_regulation ZFP36 TNF 19106809 2093296 Treatment with ERK1/2 inhibitor and SAPK/JNK inhibitor decreased *induced* [TTP] expression . Positive_regulation ZFP36 TNF 19106809 2093298 Immunoprecipitation and Western blot analysis showed that the *mediated* activation of [TTP] might be inhibited by p38 mitogen activated protein kinase inhibitor and by PD98059 . Positive_regulation ZFP36 TNF 22995314 2698015 Excessive expression *induces* [tristetraprolin (TTP)] , an RNA binding protein that regulates mRNA degradation , which in turn downregulates TNF and its downstream genes , thus resulting in anti-inflammatory effects . Positive_regulation ZFP36 TNF 24095726 2878798 Inhibition of HO-1 activity or HO-1 expression attenuated the effects of nicotine on STAT3 activation , [TTP] *induction* , and production in LPS treated macrophages . Positive_regulation ZFP36 TNF 24095726 2878806 In an LPS induced endotoxemia model , HO-1 deficiency blocked the effects of nicotine on the STAT3 phosphorylation , [TTP] *induction* , and LPS induced production in the liver . Positive_regulation ZFP37 TLR7 23857586 2829749 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP41 TLR7 23857586 2829859 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP42 TLR7 23857586 2829899 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP57 BMP2 16943432 1609637 [Zfp423] also binds to Smad1/Smad4 in *response* to signaling . Positive_regulation ZFP57 BMP2 24891617 2946062 In contrast , marrow adiposity within BMP2 induced bone was markedly enhanced in Zfp521-deficient mice , suggesting that precursor cells lacking [Zfp521] differentiate preferentially into adipocytes instead of osteoblasts in *response* to . Positive_regulation ZFP57 EBF1 18338816 1931983 Finally , we demonstrate that deficiency also *results* in reduced expression of another striatonigral-specific transcription factor , [zinc finger binding protein 521 (Zfp521)] , which is a known Ebf1 functional partner . Positive_regulation ZFP57 MYLIP 22465325 2583199 In this study , we found the expression of [Zfp521] declined with the neural differentiation of MSCs , and could *promote* the neural differentiation via targeting Zfp521 . Positive_regulation ZFP57 POU5F1 15845352 1398578 We also found that forced expression of a dominant negative mutant of STAT3 or repression of expression *led* to down-regulation of [Zfp-57] . Positive_regulation ZFP57 POU5F1 17344211 1726856 and Sox2 directly *regulate* expression of another pluripotency transcription factor , [Zfp206] , in embryonic stem cells . Positive_regulation ZFP57 PTH1R 21642473 2470654 Our results show that Zfp521 expression is up-regulated in Jansen mouse growth plate chondrocytes and that is *required* for [Zfp521] expression . Positive_regulation ZFP57 PTHLH 20951345 2333392 We found that *increases* the expression of [Zfp521] , a zinc finger transcriptional coregulator , in prehypertrophic chondrocytes . Positive_regulation ZFP57 SOX17 18523156 1945405 directly *activates* [Zfp202] transcription during in vitro endoderm differentiation . Positive_regulation ZFP57 SOX17 18523156 1945423 [Zfp202] is *induced* concomitantly with during endoderm differentiation of F9 cells . Positive_regulation ZFP57 SOX2 17344211 1726855 Oct4 and directly *regulate* expression of another pluripotency transcription factor , [Zfp206] , in embryonic stem cells . Positive_regulation ZFP57 STAT3 15845352 1398576 The expression of Zfp-57 was restricted to undifferentiated ES cells and activation of *led* to expression of [Zfp-57] . Positive_regulation ZFP57 TLR1 23857586 2829794 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP57 TLR10 23857586 2829802 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP57 TLR2 23857586 2829795 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP57 TLR3 23857586 2829796 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP57 TLR4 23857586 2829797 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP57 TLR5 23857586 2829798 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP57 TLR6 23857586 2829803 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP57 TLR7 23857586 2829799 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP57 TLR8 23857586 2829800 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP57 TLR9 23857586 2829801 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP57 TRIM28 22110054 2509537 These results , together with the analysis of embryos bearing a conditional inactivation of Trim28 in embryonic derived tissues , revealed that is differentially *required* by [ZFP568] and other factors during the early stages of mouse embryogenesis . Positive_regulation ZFP57 TRIM28 22496453 2607283 Phosphorylation of at Ser-473 attenuated its binding to the heterochromatin protein 1 family proteins and *inhibited* its transcriptional repression of KRAB-zinc finger protein ( [KRAB-ZFP] ) target genes . Positive_regulation ZFP62 TLR7 23857586 2829809 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP64 TLR7 23857586 2829779 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP69 TLR7 23857586 2829839 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP82 TLR7 23857586 2829869 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP90 TLR7 23857586 2829829 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP91 TLR7 23857586 2829769 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZFP92 TLR7 23857586 2829759 Here we showed that the expression of C2H2-type [ZFP] , ZFP64 , was significantly up-regulated in macrophages upon *stimulation* with ligands , including LPS , CpG oligodeoxynucleotides , or poly ( I:C ) . Positive_regulation ZGLP1 EPHB2 12364324 1019144 GLP1 stimulated activation of is blocked by inhibitors of MEK , but [GLP1] does not *induce* the activation of A-Raf , B-Raf , C-Raf , or Ras . Positive_regulation ZGLP1 GLP1R 21441444 2421878 Blocking endogenous action *increased* endogenous [GLP-1] secretion in all groups and increased postprandial glucose , glucagon , and GE in T1D+ and T1D- patients . Positive_regulation ZGLP1 GPR115 22650224 2610487 [GLP-1] *acts* through a present on the membranes of many tissues , including myocardium and endothelium . Positive_regulation ZGLP1 GPR115 23269670 2741671 Here , we show that the , family C group 6 subtype A ( GPRC6A ) , is *involved* in amino acid induced [GLP-1] secretion from the intestinal L cell line GLUTag . Positive_regulation ZGLP1 GPR132 22650224 2610476 [GLP-1] *acts* through a present on the membranes of many tissues , including myocardium and endothelium . Positive_regulation ZGLP1 GPR132 23269670 2741660 Here , we show that the , family C group 6 subtype A ( GPRC6A ) , is *involved* in amino acid induced [GLP-1] secretion from the intestinal L cell line GLUTag . Positive_regulation ZGLP1 GPR87 22650224 2610556 [GLP-1] *acts* through a present on the membranes of many tissues , including myocardium and endothelium . Positive_regulation ZGLP1 GPR87 23269670 2741740 Here , we show that the , family C group 6 subtype A ( GPRC6A ) , is *involved* in amino acid induced [GLP-1] secretion from the intestinal L cell line GLUTag . Positive_regulation ZIC1 ZIC2 9739105 531853 Our findings suggest that Zic1 and have essentially the same properties as Zic3 and that the Xenopus [Zic family] may *act* cooperatively in the initial phase of neural and neural crest development . Positive_regulation ZIC2 EPHA4 24360543 2881704 [Zic2] *induces* expression in dorsospinal neurons to prevent midline crossing while Robo3 is downregulated to ensure that axons enter the dorsal tracts instead of growing ventrally . Positive_regulation ZIC2 FGF8 17948241 1844472 We further show that can *induce* the expression of [Zic2] , which is normally expressed at the midline and is required in vivo for hemispheric cleavage , suggesting that FGF signaling may stimulate dorsal midline development by inducing Zic2 expression . Positive_regulation ZIC2 MYF5 21211521 2386302 activation in newly forming somites is delayed in Zic2 mutant embryos until the time of Zic1 activation , and both [Zic2] and Myf5 *require* noggin for their activation . Positive_regulation ZIC2 NOG 21211521 2386303 Myf5 activation in newly forming somites is delayed in Zic2 mutant embryos until the time of Zic1 activation , and both [Zic2] and Myf5 *require* for their activation . Positive_regulation ZIC2 ZIC1 9739105 531857 Our findings suggest that Zic1 and [Zic2] have essentially the same properties as Zic3 and that the Xenopus may *act* cooperatively in the initial phase of neural and neural crest development . Positive_regulation ZIC2 ZIC2 9739105 531858 Our findings suggest that Zic1 and have essentially the same properties as Zic3 and that the Xenopus [Zic family] may *act* cooperatively in the initial phase of neural and neural crest development . Positive_regulation ZIC2 ZIC3 9739105 531859 Our findings suggest that Zic1 and [Zic2] have essentially the same properties as Zic3 and that the Xenopus may *act* cooperatively in the initial phase of neural and neural crest development . Positive_regulation ZIC2 ZIC4 9739105 531861 Our findings suggest that Zic1 and [Zic2] have essentially the same properties as Zic3 and that the Xenopus may *act* cooperatively in the initial phase of neural and neural crest development . Positive_regulation ZIC2 ZIC5 9739105 531860 Our findings suggest that Zic1 and [Zic2] have essentially the same properties as Zic3 and that the Xenopus may *act* cooperatively in the initial phase of neural and neural crest development . Positive_regulation ZIC3 ZIC2 9739105 531863 Our findings suggest that Zic1 and have essentially the same properties as Zic3 and that the Xenopus [Zic family] may *act* cooperatively in the initial phase of neural and neural crest development . Positive_regulation ZIC4 ZIC2 9739105 531867 Our findings suggest that Zic1 and have essentially the same properties as Zic3 and that the Xenopus [Zic family] may *act* cooperatively in the initial phase of neural and neural crest development . Positive_regulation ZIC5 ZIC2 9739105 531865 Our findings suggest that Zic1 and have essentially the same properties as Zic3 and that the Xenopus [Zic family] may *act* cooperatively in the initial phase of neural and neural crest development . Positive_regulation ZNF10 TNF 11426589 765424 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF100 TNF 11426589 765425 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF101 TNF 11426589 765426 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF106 TNF 11426589 765427 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF107 TNF 11426589 765428 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF112 TNF 11426589 765429 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF114 TNF 11426589 765430 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF117 TNF 11426589 765431 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF12 TNF 11426589 765432 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF121 TNF 11426589 765433 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF124 TNF 11426589 765434 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF131 TNF 11426589 765435 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF132 TNF 11426589 765436 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF133 TNF 11426589 765437 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF134 TNF 11426589 765438 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF135 TNF 11426589 765439 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF136 TNF 11426589 765440 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF138 TNF 11426589 765441 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF14 TNF 11426589 765442 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF140 TNF 11426589 765443 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF141 TNF 11426589 765444 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF142 TNF 11426589 765445 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF143 TNF 11426589 765446 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF146 TNF 11426589 765447 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF148 TNF 11426589 765448 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF154 TNF 11426589 765449 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF155 TNF 11426589 765450 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF157 TNF 11426589 765451 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF16 TNF 11426589 765453 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF160 TNF 11426589 765454 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF165 TNF 11426589 765455 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF169 TNF 11426589 765456 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF17 TNF 11426589 765457 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF174 TNF 11426589 765458 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF175 TNF 11426589 765459 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF177 TNF 11426589 765460 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF18 TNF 11426589 765461 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF180 TNF 11426589 765462 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF181 TNF 11426589 765463 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF182 TNF 11426589 765477 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF184 TNF 11426589 765464 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF185 TNF 11426589 765465 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF189 TNF 11426589 765466 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF19 TNF 11426589 765467 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF195 TNF 11426589 765468 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF197 TNF 11426589 765469 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF2 TNF 11426589 765470 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF20 TNF 11426589 765471 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF200 TNF 11426589 765472 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF202 TNF 11426589 765473 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF205 TNF 11426589 765474 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF207 TNF 11426589 765475 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF208 TNF 11426589 765476 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF211 TNF 11426589 765478 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF212 TNF 11426589 765479 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF213 TNF 11426589 765480 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF214 TNF 11426589 765481 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF215 TNF 11426589 765482 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF217 TNF 11426589 765483 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF219 TNF 11426589 765484 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF22 TNF 11426589 765485 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF221 TNF 11426589 765486 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF222 TNF 11426589 765487 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF223 TNF 11426589 765488 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF224 TNF 11426589 765489 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF225 TNF 11426589 765490 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF226 TNF 11426589 765491 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF227 TNF 11426589 765492 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF229 TNF 11426589 765493 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF23 TNF 11426589 765494 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF230 TNF 11426589 765495 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF232 TNF 11426589 765496 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF233 TNF 11426589 765860 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF234 TNF 11426589 765497 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF235 TNF 11426589 765423 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF236 TNF 11426589 765498 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF239 TNF 11426589 765499 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF24 TNF 11426589 765500 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF248 TNF 11426589 765501 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF25 TNF 11426589 765502 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF250 TNF 11426589 765503 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF251 TNF 11426589 765504 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF253 TNF 11426589 765561 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF254 TNF 11426589 765505 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF256 TNF 11426589 765506 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF257 TNF 11426589 765562 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF259 TNF 11426589 765507 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF26 TNF 11426589 765508 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF260 TNF 11426589 765563 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF263 TNF 11426589 765509 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF264 TNF 11426589 765510 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF266 TNF 11426589 765511 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF267 TNF 11426589 765512 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF268 TNF 11426589 765513 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF271 TNF 11426589 765514 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF273 TNF 11426589 765515 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF274 TNF 11426589 765516 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF275 TNF 11426589 765517 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF276 TNF 11426589 765666 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF277 TNF 11426589 765518 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF28 TNF 11426589 765519 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF281 TNF 11426589 765520 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF282 TNF 11426589 765521 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF283 TNF 11426589 765522 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF284 TNF 11426589 765523 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF285 TNF 11426589 765524 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF287 TNF 11426589 765564 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF292 TNF 11426589 765604 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF296 TNF 11426589 765582 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF3 TNF 11426589 765525 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF30 TNF 11426589 765526 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF300 TNF 11426589 765527 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF302 TNF 11426589 765572 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF304 TNF 11426589 765565 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF311 TNF 11426589 765571 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF316 TNF 11426589 765570 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF317 TNF 11426589 765566 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF318 TNF 11426589 765567 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF319 TNF 11426589 765568 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF32 TNF 11426589 765528 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF320 TNF 11426589 765569 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF322 TNF 11426589 765673 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF324 TNF 11426589 765573 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF326 TNF 11426589 765574 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF329 TNF 11426589 765575 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF330 TNF 11426589 765576 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF331 TNF 11426589 765577 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF333 TNF 11426589 765578 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF334 TNF 11426589 765579 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF335 TNF 11426589 765580 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF337 TNF 11426589 765581 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF34 TNF 11426589 765529 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF341 TNF 11426589 765583 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF343 TNF 11426589 765584 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF345 TNF 11426589 765587 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF346 TNF 11426589 765588 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF347 TNF 11426589 765589 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF35 TNF 11426589 765530 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF350 TNF 11426589 765590 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF358 TNF 11426589 765594 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF362 TNF 11426589 765598 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF365 TNF 11426589 765600 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF366 TNF 11426589 765601 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF367 TNF 11426589 765602 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF382 TNF 11426589 765595 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF383 TNF 11426589 765605 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF384 TNF 11426589 765422 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF391 TNF 11426589 765607 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF394 TNF 11426589 765610 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF395 TNF 11426589 765606 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF396 TNF 11426589 765609 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF397 TNF 11426589 765608 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF398 TNF 11426589 765603 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF404 TNF 11426589 765611 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF407 TNF 11426589 765612 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF408 TNF 11426589 765613 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF41 TNF 11426589 765531 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF410 TNF 11426589 765614 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF414 TNF 11426589 765618 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF415 TNF 11426589 765619 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF416 TNF 11426589 765620 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF417 TNF 11426589 765621 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF418 TNF 11426589 765622 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF419 TNF 11426589 765623 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF420 TNF 11426589 765624 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF423 TNF 11426589 765593 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF425 TNF 11426589 765625 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF426 TNF 11426589 765626 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF428 TNF 11426589 765627 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF429 TNF 11426589 765634 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF43 TNF 11426589 765532 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF430 TNF 11426589 765629 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF431 TNF 11426589 765630 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF432 TNF 11426589 765631 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF433 TNF 11426589 765632 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF436 TNF 11426589 765633 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF438 TNF 11426589 765641 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF439 TNF 11426589 765635 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF44 TNF 11426589 765533 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF440 TNF 11426589 765636 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF441 TNF 11426589 765637 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF442 TNF 11426589 765638 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF443 TNF 11426589 765639 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF444 TNF 11426589 765585 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF445 TNF 11426589 765640 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF446 TNF 11426589 765642 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF449 TNF 11426589 765643 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF45 TNF 11426589 765534 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF451 TNF 11426589 765644 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF454 TNF 11426589 765645 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF460 TNF 11426589 765646 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF461 TNF 11426589 765647 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF462 TNF 11426589 765648 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF467 TNF 11426589 765657 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF468 TNF 11426589 765882 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF469 TNF 11426589 765659 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF470 TNF 11426589 765655 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF471 TNF 11426589 765660 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF473 TNF 11426589 765661 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF474 TNF 11426589 765662 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF479 TNF 11426589 765663 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF48 TNF 11426589 765535 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF480 TNF 11426589 765665 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF483 TNF 11426589 765667 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF484 TNF 11426589 765668 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF485 TNF 11426589 765669 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF486 TNF 11426589 765628 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF487 TNF 11426589 765670 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF488 TNF 11426589 765671 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF490 TNF 11426589 765674 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF491 TNF 11426589 765675 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF492 TNF 11426589 765676 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF493 TNF 11426589 765677 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF496 TNF 11426589 765678 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF497 TNF 11426589 765679 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF500 TNF 11426589 765680 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF501 TNF 11426589 765681 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF502 TNF 11426589 765682 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF503 TNF 11426589 765672 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF506 TNF 11426589 765683 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF507 TNF 11426589 765684 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF510 TNF 11426589 765830 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF511 TNF 11426589 765804 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF512 TNF 11426589 765837 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF513 TNF 11426589 765749 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF514 TNF 11426589 765723 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF516 TNF 11426589 765823 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF517 TNF 11426589 765784 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF519 TNF 11426589 765854 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF521 TNF 11426589 765685 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF524 TNF 11426589 765799 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF525 TNF 11426589 765843 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF526 TNF 11426589 765841 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF527 TNF 11426589 765839 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF528 TNF 11426589 765838 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF529 TNF 11426589 765836 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF530 TNF 11426589 765835 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF532 TNF 11426589 765858 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF534 TNF 11426589 765735 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF536 TNF 11426589 765827 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF540 TNF 11426589 765705 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF541 TNF 11426589 765704 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF542 TNF 11426589 765709 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF543 TNF 11426589 765702 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF544 TNF 11426589 765592 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF546 TNF 11426589 765811 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF547 TNF 11426589 765743 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF548 TNF 11426589 765750 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF549 TNF 11426589 765753 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF550 TNF 11426589 765808 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF551 TNF 11426589 765696 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF552 TNF 11426589 765730 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF554 TNF 11426589 765752 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF555 TNF 11426589 765802 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF556 TNF 11426589 765713 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF557 TNF 11426589 765807 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF558 TNF 11426589 765741 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF559 TNF 11426589 765796 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF56 TNF 11426589 765536 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF560 TNF 11426589 765747 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF561 TNF 11426589 765813 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF562 TNF 11426589 765727 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF563 TNF 11426589 765851 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF564 TNF 11426589 765866 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF565 TNF 11426589 765757 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF566 TNF 11426589 765724 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF567 TNF 11426589 765814 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF568 TNF 11426589 765708 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF569 TNF 11426589 765687 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF57 TNF 11426589 765537 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF570 TNF 11426589 765738 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF571 TNF 11426589 765693 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF572 TNF 11426589 765759 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF573 TNF 11426589 765739 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF574 TNF 11426589 765731 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF575 TNF 11426589 765778 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF576 TNF 11426589 765801 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF577 TNF 11426589 765812 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF578 TNF 11426589 765744 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF579 TNF 11426589 765754 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF580 TNF 11426589 765846 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF581 TNF 11426589 765694 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF582 TNF 11426589 765740 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF583 TNF 11426589 765742 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF584 TNF 11426589 765776 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF586 TNF 11426589 765726 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF587 TNF 11426589 765864 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF589 TNF 11426589 765591 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF592 TNF 11426589 765822 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF593 TNF 11426589 765859 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF594 TNF 11426589 765840 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF595 TNF 11426589 765770 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF596 TNF 11426589 765774 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF597 TNF 11426589 765751 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF598 TNF 11426589 765793 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF599 TNF 11426589 765737 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF600 TNF 11426589 765862 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF605 TNF 11426589 765791 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF606 TNF 11426589 765720 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF607 TNF 11426589 765795 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF608 TNF 11426589 765832 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF609 TNF 11426589 765824 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF610 TNF 11426589 765755 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF611 TNF 11426589 765818 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF613 TNF 11426589 765717 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF614 TNF 11426589 765686 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF615 TNF 11426589 765688 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF616 TNF 11426589 765789 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF618 TNF 11426589 765842 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF619 TNF 11426589 765764 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF620 TNF 11426589 765817 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF621 TNF 11426589 765691 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF622 TNF 11426589 765865 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF623 TNF 11426589 765828 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF624 TNF 11426589 765833 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF625 TNF 11426589 765853 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF626 TNF 11426589 765848 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF627 TNF 11426589 765852 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF628 TNF 11426589 765788 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF629 TNF 11426589 765826 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF630 TNF 11426589 765820 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF638 TNF 11426589 765597 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF639 TNF 11426589 765861 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF641 TNF 11426589 765867 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF644 TNF 11426589 765831 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF645 TNF 11426589 765736 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF646 TNF 11426589 765825 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF648 TNF 11426589 765599 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF649 TNF 11426589 765715 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF652 TNF 11426589 765829 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF653 TNF 11426589 765700 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF654 TNF 11426589 765712 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF655 TNF 11426589 765856 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF658 TNF 11426589 765701 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF66 TNF 11426589 765539 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF660 TNF 11426589 765756 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF662 TNF 11426589 765868 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF663 TNF 11426589 765706 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF664 TNF 11426589 765710 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF665 TNF 11426589 765722 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF667 TNF 11426589 765819 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF668 TNF 11426589 765716 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF669 TNF 11426589 765714 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF670 TNF 11426589 765794 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF671 TNF 11426589 765734 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF672 TNF 11426589 765732 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF674 TNF 11426589 765596 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF675 TNF 11426589 765855 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF676 TNF 11426589 765616 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF677 TNF 11426589 765816 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF678 TNF 11426589 765810 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF679 TNF 11426589 765809 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF680 TNF 11426589 765763 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF681 TNF 11426589 765745 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF682 TNF 11426589 765821 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF683 TNF 11426589 765805 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF684 TNF 11426589 765803 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF687 TNF 11426589 765834 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF688 TNF 11426589 765850 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF689 TNF 11426589 765699 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF69 TNF 11426589 765540 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF691 TNF 11426589 765786 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF692 TNF 11426589 765728 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF695 TNF 11426589 765863 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF696 TNF 11426589 765719 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF697 TNF 11426589 765869 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF699 TNF 11426589 765689 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF7 TNF 11426589 765541 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF70 TNF 11426589 765542 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF700 TNF 11426589 765703 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF701 TNF 11426589 765711 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF703 TNF 11426589 765721 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF704 TNF 11426589 765871 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF706 TNF 11426589 765692 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF707 TNF 11426589 765783 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF708 TNF 11426589 765452 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF709 TNF 11426589 765617 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF71 TNF 11426589 765543 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF710 TNF 11426589 765707 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF711 TNF 11426589 765538 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF713 TNF 11426589 765653 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF714 TNF 11426589 765768 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF716 TNF 11426589 765872 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF717 TNF 11426589 765845 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF718 TNF 11426589 765761 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF720 TNF 11426589 765765 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF721 TNF 11426589 765844 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF723 TNF 11426589 765870 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF726 TNF 11426589 765873 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF727 TNF 11426589 765656 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF728 TNF 11426589 765874 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF729 TNF 11426589 765875 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF73 TNF 11426589 765544 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF730 TNF 11426589 765880 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF732 TNF 11426589 765902 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF735 TNF 11426589 765876 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF736 TNF 11426589 765877 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF737 TNF 11426589 765878 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF738 TNF 11426589 765879 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF74 TNF 11426589 765545 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF740 TNF 11426589 765777 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF746 TNF 11426589 765652 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF747 TNF 11426589 765800 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF749 TNF 11426589 765881 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF750 TNF 11426589 765718 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF76 TNF 11426589 765546 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF761 TNF 11426589 765658 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF763 TNF 11426589 765780 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF764 TNF 11426589 765797 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF765 TNF 11426589 765695 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF766 TNF 11426589 765790 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF767 TNF 11426589 765651 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF768 TNF 11426589 765733 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF77 TNF 11426589 765547 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF770 TNF 11426589 765729 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF771 TNF 11426589 765847 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF772 TNF 11426589 765883 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF773 TNF 11426589 765849 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF774 TNF 11426589 765884 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF775 TNF 11426589 765806 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF776 TNF 11426589 765760 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF777 TNF 11426589 765654 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF778 TNF 11426589 765746 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF781 TNF 11426589 765758 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF782 TNF 11426589 765885 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF783 TNF 11426589 765771 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF784 TNF 11426589 765886 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF785 TNF 11426589 765748 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF786 TNF 11426589 765650 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF787 TNF 11426589 765767 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF788 TNF 11426589 765887 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF789 TNF 11426589 765782 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF79 TNF 11426589 765548 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF790 TNF 11426589 765888 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF791 TNF 11426589 765762 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF792 TNF 11426589 765690 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF793 TNF 11426589 765889 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF799 TNF 11426589 765792 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF8 TNF 11426589 765549 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF80 TNF 11426589 765550 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF800 TNF 11426589 765773 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF805 TNF 11426589 765664 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF806 TNF 11426589 765890 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF807 TNF 11426589 765891 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF808 TNF 11426589 765892 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF81 TNF 11426589 765551 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF812 TNF 11426589 765893 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF813 TNF 11426589 765894 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF814 TNF 11426589 765895 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF816 TNF 11426589 765766 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF821 TNF 11426589 765787 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF823 TNF 11426589 765857 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF827 TNF 11426589 765769 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF829 TNF 11426589 765896 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF83 TNF 11426589 765552 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF830 TNF 11426589 765798 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF831 TNF 11426589 765586 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF835 TNF 11426589 765897 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF836 TNF 11426589 765898 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF837 TNF 11426589 765698 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF839 TNF 11426589 765615 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF84 TNF 11426589 765553 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF840 TNF 11426589 765899 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF841 TNF 11426589 765779 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF843 TNF 11426589 765815 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF844 TNF 11426589 765725 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF845 TNF 11426589 765697 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF846 TNF 11426589 765772 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF85 TNF 11426589 765554 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF850 TNF 11426589 765785 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF852 TNF 11426589 765781 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF853 TNF 11426589 765649 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF860 TNF 11426589 765900 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF862 TNF 11426589 765901 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF865 TNF 11426589 765907 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF878 TNF 11426589 765903 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF879 TNF 11426589 765905 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF880 TNF 11426589 765904 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF883 TNF 11426589 765775 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF888 TNF 11426589 765906 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF891 TNF 11426589 765908 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF90 TNF 11426589 765555 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF91 TNF 11426589 765556 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF92 TNF 11426589 765557 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF93 TNF 11426589 765558 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF98 TNF 11426589 765559 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZNF99 TNF 11426589 765560 Among the 155 genes encoding zinc finger motif , the level of EST M88357 mRNA encoding a novel designated EZFIT ( endothelial [zinc finger protein] *induced* by ) was induced most profoundly ( > 19 fold ) . Positive_regulation ZWINT STK39 18083840 1836972 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation A2M IL1B 11466367 839950 The inhibitory *effect* of on IL-6 induced [alpha 2-macroglobulin] expression is due to activation of NF-kappa B . Regulation A2M IL1B 11466367 839957 The observation that inhibition of IL-6 induced transcriptional activation of this promoter by IL-1beta is reversed by cotransfection with I-kappaBalpha provides evidence that NF-kappaB activation by is *responsible* for inhibition of IL-6 mediated trans activation of the [alpha(2)-macroglobulin] gene . Regulation ABCA1 CAPN8 20395597 2273881 The activity of [ABCA1] is *regulated* through proteolysis by . Regulation ABCA1 S100B 23523156 2818698 The aim of the present study is to examine the *effect* of RAGE ligand on [ABCA1] expression . Regulation ABCA1 S100B 23523156 2818700 *Effect* of on [ABCA1] and ABCG1 expression was reversed by LXR ligand treatment . Regulation ABCA1 TNF 17689273 1805692 This study investigates the *effects* of and interleukin-10 (IL-10) on [ABCA1] expression and cholesterol content in THP-1 macrophage derived foam cells . Regulation ABCA1 TNF 18155667 1862696 *affects* cholesterol efflux and [ABCA1] expression of adipocytes , and the pathway of PPARgamma-LXRalpha-ABCA1 is probably involved . Regulation ABCA1 TNF 19913791 2224831 Here we examined the *role* of in [ABCA1] induction and tested the effects of lymphotoxin-alpha (LT) , another TNF family member , on macrophage ABCA1 levels . Regulation ABCA1 TNF 20103810 2248398 The *regulation* of [ABCA1] and HDL cholesterol efflux by was investigated in the human intestinal cell line Caco-2 . Regulation ABCA1 TNF 23914732 2830653 PKC-? inhibition by PKC-? siRNA attenuated the *effect* of on [ABCA1] , ABCG1 , LXRa , SR-A , CD-36 expression . Regulation ABCA12 MT-CO3 24950409 2947216 In the cell-free assay [Li2CO3] significantly inhibited phosphoinositide 3-kinase (PI3K) mediated phosphorylation of Akt1 at Ser473 , but did not *affect* PI3K mediated PI ( 3,4,5 ) P3 production and 3-phosphoinositide dependent protein kinase 1 ( PDK1 ) -mediated phosphorylation of Akt1 at Thr308 . Regulation ABCA4 EMB 15455591 1301171 A significant finding is that PZA and perhaps may *play* a catalytic role in the interaction between INH and [RMP] . Regulation ABCA4 ENO2 19526857 2098629 *Effects* of and OEA on [RMP] and repolarization phase of AP ( phase 3 ) depended on cardiac cell type suggesting differential regulation of inward rectifier Kir and voltage gated delayed rectifier potassium channels by these lipids . Regulation ABCA4 FGFR3 366554 8259 Using intracellular microelectrodes , [resting membrane potential (RMP)] and depolarisation in *response* to added to the bathing medium were recorded in endplate-free regions of the muscle fibres . Regulation ABCA4 INS 8253874 238428 Using conventional microelectrode techniques , we investigated the combined *effects* of isoproterenol ( Iso ) and on the [resting membrane potential (RMP)] of isolated rat skeletal muscles . Regulation ABCA4 KIR3DL1 16797534 1612709 The results provide evidence of a predominant role for Kir in setting the oligodendroglial RMP and show that cAMP *regulates* the oligodendroglial [RMP] , at least partly by a PKA mediated pathway , possibly by modulating the activity of . Regulation ABCA4 PRKACB 16856152 1607187 This study provides evidence that the heterogeneous [RMP] of mature astrocytes is *regulated* by cAMP and signaling . Regulation ABCA4 PRKACG 16856152 1607188 This study provides evidence that the heterogeneous [RMP] of mature astrocytes is *regulated* by cAMP and signaling . Regulation ABCA4 PRKAR1A 16856152 1607189 This study provides evidence that the heterogeneous [RMP] of mature astrocytes is *regulated* by cAMP and signaling . Regulation ABCA4 PRKAR1B 16856152 1607190 This study provides evidence that the heterogeneous [RMP] of mature astrocytes is *regulated* by cAMP and signaling . Regulation ABCA4 PRKAR2A 16856152 1607191 This study provides evidence that the heterogeneous [RMP] of mature astrocytes is *regulated* by cAMP and signaling . Regulation ABCA4 PRKAR2B 16856152 1607192 This study provides evidence that the heterogeneous [RMP] of mature astrocytes is *regulated* by cAMP and signaling . Regulation ABCA4 TNF 15381257 1298676 Here , we report the *effect* of and its second messenger ceramide on the [resting membrane potential (RMP)] of thyroid FRTL-5 cells . Regulation ABCA4 TRPV5 21328349 2480355 Detection of TRPV5 by PCR and immunohistochemistry and the sensitivity of the RMP to the TRPV5 inhibitor econazole ( ?V ( m ) = -18 ± 3 mV ) suggests that the [RMP] may be , in part , *controlled* by . Regulation ABCB1 FOXO1 18390843 1951286 *Role* of activation in [MDR1] expression in adriamycin-resistant breast cancer cells . Regulation ABCB1 MX2 10070877 594290 The *effects* of 4-demethoxydaunorubicin ( idarubicin , IDA ) and , a new morpholino-anthracycline , on up-regulation of the [MDR1] gene in the low-level multidrug resistant ( MDR ) cell line CEM/A7R were compared at similar concentrations ( IC10 , IC50 and IC90 ) over a short time exposure ( 4 and 24 h ) . Regulation ABCB1 PTGER2 16415092 1533852 The *role* of dependent signaling via cAMP in [Mdr1b] gene activation in primary rat hepatocyte cultures . Regulation ABCB1 TNFSF10 25276252 2959050 *Effect* of in combination with DDP on the expression of [MDR1] gene in gastric cancer cells . Regulation ABCC1 FOXO1 23763570 2882285 This study aimed to investigate the *role* of in regulating [MRP2] gene expression in TAMR-MCF-7 cells . Regulation ABCC1 TNF 23125159 2721582 Furthermore , increased levels of and IL-18 in experimental NEC may *play* a role in the regulation of Ntcp and [Mrp2] , respectively . Regulation ABCC1 TNF 9182980 436364 In this study , we examined the *effects* of on [MRP] and LRP gene expression in the same colon carcinoma cells . Regulation ABCG1 CAPN8 21295304 2410292 Here , we show the *role* of in [ABCG1] degradation . Regulation ABCG1 S100B 23523156 2818701 *Effect* of on ABCA1 and [ABCG1] expression was reversed by LXR ligand treatment . Regulation ABCG2 ABCC2 19508886 2108612 These results show that in brain the *effect* of Abcb1 , and Abcg2 should be negligible and that at the hepato-biliary level , Abcb1 plays a predominant role compared to Abcc2 and [Abcg2] . Regulation ABCG2 AHR 20804740 2330536 Here , we demonstrate the *dependent* induction of [ABCG2] expression in human colon adenocarcinoma LS174T cells . Regulation ABCG2 AHR 21678497 2579242 Reporter gene assay , chromatin immunoprecipitation analysis and specific gene knockdown confirmed that the enhanced binding to a xenobiotic response element ( XRE ) within the ABCG2 promoter is *responsible* for [ABCG2] overexpression . Regulation ABCG2 AHR 24389113 2911998 Thus , [ABCG2] *regulation* by ligands including ubiquitously environmental pollutants is of great toxicological relevance . Regulation ABCG2 AHR 24389113 2912000 However , no adequate in vitro model is as yet available to study dependent [ABCG2] *regulation* in dairy animals . Regulation ABCG2 AHR 24389113 2912003 In contrast , activators such as PCB 101 had no significant *effect* on EROD activity , [ABCG2] gene expression or transporter activity . Regulation ABCG2 AKT1 23144836 2699531 In summary , CSC promotes chemoresistance via mediated *regulation* of [ABCG2] activity , and may also increase the proportion of cancer stem-like cells , contributing to tumor resilience . Regulation ABCG2 AKT2 23144836 2699532 In summary , CSC promotes chemoresistance via mediated *regulation* of [ABCG2] activity , and may also increase the proportion of cancer stem-like cells , contributing to tumor resilience . Regulation ABCG2 AKT3 23144836 2699533 In summary , CSC promotes chemoresistance via mediated *regulation* of [ABCG2] activity , and may also increase the proportion of cancer stem-like cells , contributing to tumor resilience . Regulation ABCG2 E2F1 24276245 2948817 *regulates* [ABCG2] expression in multiple cell systems , and , importantly , we have identified a significant correlation between elevated E2F1 and ABCG2 expression in human lung cancers . Regulation ABCG2 EGF 16415123 1533861 Taken together , our data show *regulation* of [ABCG2] expression by . Regulation ABCG2 EPAS1 22452996 2588633 could *regulate* [ABCG2] in breast cancer cells , and could be a novel potential bio-marker to predict chemotherapy effectiveness . Regulation ABCG2 HDAC1 18234970 1864331 In the remaining cell lines , HDAC1 binding in association with the repressive Me3-K9 H3 mark apparently constrains the *effect* of inhibition on [ABCG2] expression . Regulation ABCG2 HDAC2 18234970 1864332 In the remaining cell lines , HDAC1 binding in association with the repressive Me3-K9 H3 mark apparently constrains the *effect* of inhibition on [ABCG2] expression . Regulation ABCG2 HGF 22922104 2678278 Here we aimed to decipher the *role* of and the related kinase cascades on the expression of [ABCG2] and the role of the different promoters in this process in the HepG2 human HCC cell line . Regulation ABCG2 IL1A 22193459 2558607 This study was aimed to evaluate the short-term ( 72-h treatment ) *effects* of , tumor necrosis factor-a (TNF-a) , and interleukin-6 (IL-6) on the expression and function of [ABCG2] in cervix carcinoma and gastric cancer cells . Regulation ABCG2 IL1A 22750628 2659712 PXR and NF-?B correlate with the inducing *effects* of and TNF-a on [ABCG2] expression in breast cancer cell lines . Regulation ABCG2 IL4 17825224 1795435 [ *Effect* of on [ABCG2] expression in human lung adenocarcinoma cell lines ] . Regulation ABCG2 IL4 17825224 1795436 To investigate the *effect* of on the expression of [ABCG2] in lung adencarcinoma cell lines . Regulation ABCG2 IL4 17825224 1795438 does not *regulate* [ABCG2] expression in human lung adencarcinoma cell lines . Regulation ABCG2 IL6 22193459 2558608 This study was aimed to evaluate the short-term ( 72-h treatment ) *effects* of interleukin-1ß (IL-1ß) , tumor necrosis factor-a (TNF-a) , and on the expression and function of [ABCG2] in cervix carcinoma and gastric cancer cells . Regulation ABCG2 KLF5 20639455 2310635 In summary , while KLF5 is not required for oncogenic mutant K-Ras induced lung tumorigenesis , *regulation* of [ABCG2] expression may be important for chemotherapeutic resistance and patient survival . Regulation ABCG2 MAPK1 23032069 2843217 To evaluate the *role* of on the expression and function of [ABCG2] , the expression of mitogen activated protein kinase (MAPK)/ERK kinase ( MEK ) , which preferentially activates ERK , was upregulated by transfection with the recombinant sense expression vector pcDNA3.1-MEK and downregulated by pretreatment with U0126 , a specific MEK inhibitor . Regulation ABCG2 MAPK3 23032069 2843218 To evaluate the *role* of on the expression and function of [ABCG2] , the expression of mitogen activated protein kinase (MAPK)/ERK kinase ( MEK ) , which preferentially activates ERK , was upregulated by transfection with the recombinant sense expression vector pcDNA3.1-MEK and downregulated by pretreatment with U0126 , a specific MEK inhibitor . Regulation ABCG2 MIR328 19270061 2079726 negatively *regulates* the expression of breast cancer resistance protein ( [BCRP/ABCG2] ) in human cancer cells . Regulation ABCG2 PPARG 16785230 1599418 We confirmed the binding of the PPARgamma x RXR heterodimer to this enhancer region , suggesting that directly *regulates* the transcription of [ABCG2] . Regulation ABCG2 PRL 23150485 2729613 We investigated the *role* of the lactogenic hormone in the regulation of [ABCG2] . Regulation ABCG2 PTGS2 20422426 2395174 Potential *role* of on the regulation of the drug efflux transporter [ABCG2] in breast cancer cell lines . Regulation ABCG2 RBBP4 18234970 1864333 In the remaining cell lines , HDAC1 binding in association with the repressive Me3-K9 H3 mark apparently constrains the *effect* of inhibition on [ABCG2] expression . Regulation ABCG2 RBBP7 18234970 1864334 In the remaining cell lines , HDAC1 binding in association with the repressive Me3-K9 H3 mark apparently constrains the *effect* of inhibition on [ABCG2] expression . Regulation ABCG2 SPR 9176265 433712 Inclusion of SPR210 antibodies blocked association of SP-A-BCG complexes , suggesting a *role* for in mediating the interaction of [SP-A-BCG] with the macrophages . Regulation ABCG2 TNF 22193459 2558606 This study was aimed to evaluate the short-term ( 72-h treatment ) *effects* of interleukin-1ß (IL-1ß) , , and interleukin-6 (IL-6) on the expression and function of [ABCG2] in cervix carcinoma and gastric cancer cells . Regulation ABCG2 TNF 22750628 2659711 PXR and NF-?B correlate with the inducing *effects* of IL-1ß and on [ABCG2] expression in breast cancer cell lines . Regulation ABCG2 TP53 19107196 2004137 The present work demonstrated that [ABCG2] protects ES cells from PPIX accumulation during colony expansion , and that and gammaH2AX *acts* as a downstream checkpoint of ABCG2 dependent defense machinery in order to maintain the self-renewal of ES cells . Regulation ABI1 CAPN8 15178460 1255357 Pak regulates *dependent* degradation of [E3b1] . Regulation ABI1 CAPN8 15178460 1255400 Here we present evidence that [E3b1] levels are *regulated* by the Ca ( 2+ ) -activated protease , and also by Pak , a downstream target of Rac signaling . Regulation ABL1 IFI27 11920258 894499 This enhanced [BCR/ABL] mediated growth inhibition occurred over a range of growth factor concentrations and was *independent* of changes in p21(Cip1) and ( Kip ) levels . Regulation ABL1 PECAM1 23233201 2724501 is *involved* in [BCR/ABL] signaling and may downregulate imatinib induced apoptosis of Philadelphia chromosome positive leukemia cells . Regulation ACACA CCND1 14714130 1347040 To evaluate the *role* of in the biological regulation of [ACC] , we constitutively expressed an antisense cyclin D1 complementary DNA ( cDNA ) in an established ACC cell line that exhibits high endogenous expression of cyclin D1 . Regulation ACACA ID1 19766362 2299380 However , the *role* of protein in salivary [adenoid cystic carcinoma (ACC)] is not clear . Regulation ACACA TNF 17222972 1703649 In the present study , we examined TNF-alpha expression in the mouse ACC following hind-paw administration of complete Freund's adjuvant (CFA) and examined the *role* of in [ACC] synaptic transmission . Regulation ACAD8 EPHB2 19755425 2158639 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Regulation ACAN CTGF 21928342 2539153 In this study we demonstrate that Wif-1 is capable to interfere with *dependent* induction of [Acan] and Col2a1 gene expression in primary murine chondrocytes . Regulation ACAN IL1B 11467894 840810 Therefore , the *effects* of on cell associated [aggrecan] , where assessed with ( 35 ) S-incorporation , did not correlate with the results of the flow cytometric assays . Regulation ACAN IL1B 19714579 2139314 Transfection of chondrocytes with ds-miR-140 down-regulated IL-1beta induced ADAMTS5 expression and rescued the *dependent* repression of [AGGRECAN] gene expression . Regulation ACAN TF 8689460 343285 The extent to which different growth or differentiation factors were able to restore 35S incorporation in aggrecan in serum-free DMEM was determined : human serum had no *effect* on [aggrecan] synthesis levels ; Regulation ACAN TNF 17923423 1888908 Nitric oxide enhances [aggrecan] degradation by aggrecanase in *response* to but not IL-1beta treatment at a post-transcriptional level in bovine cartilage explants . Regulation ACAN TNF 23602832 2789792 Lentiviral transduction with shRNA plasmids shp65 , shp52 , shIKK-a , and shIKK-ß significantly decreased *dependent* increase in ADAMTS-4 and -5 levels and [aggrecan] degradation . Regulation ACAN TNF 23602832 2789796 Silencing of either ADAMTS-4 or -5 resulted in reduction in *dependent* [aggrecan] degradation in NP cells . Regulation ACCS JAG1 22427350 2588205 Analysis of clinical data indicates that Jag1 expression correlates with both grade and stage of ACCs , supporting a *role* of dependent Notch activation in late-stage [ACCs] . Regulation ACD TNF 1516597 196792 To elucidate the *role* of in determining [anemia of chronic disease (ACD)] in rheumatoid arthritis ( RA ) , 24 patients were studied for disease parameters , TNF serum levels and bone marrow for erythroid colony growth and compared with six controls . Regulation ACE ANGPT1 18084722 1882976 Role of ACE/AT2R complex in the control of mesenteric resistance artery contraction induced by [ACE/AT1R] complex activation in *response* to . Regulation ACE EDN2 11078388 749290 *regulates* [angiotensin converting enzyme] in the mouse kidney . Regulation ACE EDN2 8723527 373742 *Effect* of on [angiotensin converting enzyme] activity in cultured vascular smooth muscle cells . Regulation ACE TNF 12160518 971793 To investigate *regulation* of [angiotensin converting enzyme (ACE)] by in differentiating human peripheral blood monocytes ( PBM ) . Regulation ACE2 ANGPT1 16166274 1476019 This study examined the effects of liver injury on [ACE2] expression and activity in experimental hepatic fibrosis and human cirrhosis , and the *effects* of on vascular tone in cirrhotic rat aorta . Regulation ACHE CAPN8 17320203 1711730 In the present study , we show that activated , a cytosolic calcium activated cysteine protease , and calcineurin , a calcium dependent protein phosphatase , *regulate* [acetylcholinesterase] expression during A23187 induced apoptosis . Regulation ACHE TNF 18639629 2010676 Here we report that brain [acetylcholinesterase] activity *controls* systemic and organ specific production during endotoxemia . Regulation ACO1 TF 17127713 1716708 [IRP1] coordinately *controls* the expression of and ferritin by binding to iron-responsive elements ( IREs ) within their mRNAs . Regulation ACO1 TNF 8837751 386488 did not measurably *affect* [aconitase] activity , and thus mitochondrial 02.- production , in either cultured human A549 cells or murine L929 cells while TNF alpha clearly caused cytotoxicity as revealed by impaired mitochondrial respiration . Regulation ACP1 TNF 23238125 2731763 In addition , the ability of bone marrow derived monocytes/macrophages from the siglec-15 ( -/- ) mice to differentiate into osteoclasts was impaired , as determined in vitro by cellular tartrate-resistant [acid phosphatase] activity in *response* to the receptor activator of nuclear factor-?B ligand or . Regulation ACP2 TNF 23238125 2731764 In addition , the ability of bone marrow derived monocytes/macrophages from the siglec-15 ( -/- ) mice to differentiate into osteoclasts was impaired , as determined in vitro by cellular tartrate-resistant [acid phosphatase] activity in *response* to the receptor activator of nuclear factor-?B ligand or . Regulation ACP2 TNF 9576761 502871 An increase in *dependent* nuclear expression of CCAAT/enhancer binding protein-beta ( C/EBP-beta ) [/liver enriched activating protein (LAP)] was detected after 1 h , whereas an increase in RNA expression was evident only after 4 h. C/EBP-beta/LAP expression returned to normal values before progression into the S-phase . Regulation ACP5 TNF 23238125 2731765 In addition , the ability of bone marrow derived monocytes/macrophages from the siglec-15 ( -/- ) mice to differentiate into osteoclasts was impaired , as determined in vitro by cellular tartrate-resistant [acid phosphatase] activity in *response* to the receptor activator of nuclear factor-?B ligand or . Regulation ACP6 TNF 23238125 2731766 In addition , the ability of bone marrow derived monocytes/macrophages from the siglec-15 ( -/- ) mice to differentiate into osteoclasts was impaired , as determined in vitro by cellular tartrate-resistant [acid phosphatase] activity in *response* to the receptor activator of nuclear factor-?B ligand or . Regulation ACSL3 FAS 15556626 1340232 Triacsin C , an inhibitor of FACL3 activity , completely abolished the downregulation of FAS expression by vitamin D3 , whereas an inhibitor of activity , cerulenin , had no significant *effect* on the upregulation of [FACL3] expression by vitamin D3 in LNCaP cells . Regulation ACSS1 INS 22275878 2545262 We show that multiple [ACSs] are also transcriptionally *regulated* by signaling in mammalian cells . Regulation ACSS1 KLF15 14960588 1235344 Characterization of 5'-flanking region of the mouse AceCS2 gene demonstrates that *plays* a key role in the trans-activation of the [AceCS2] gene . Regulation ACSS2 EDN2 9230761 444750 To investigate the *role* of the endothelial derived vasoactive mediator ( ET-1 ) in the [acute chest syndrome (ACS)] , we incubated bovine pulmonary artery endothelial cells ( BPAEC ) with red blood cells ( equivalent to a hematocrit of 20 % ) and/or autologous plasma ( 1 : 10 dilution ) from two patients during ACS and during routine clinic visits . Regulation ACTB FAS 17394485 1721059 Finally , in *response* to receptor activation or staurosporine treatment the levels of [beta-actin] or alpha-tubulin remained unaltered , whereas several Golgi proteins , p115 and golgin-160 , underwent caspase mediated cleavage . Regulation ACTB TGM2 21789544 2546638 [Beta-actin] is a *target* for activity at synaptic endings in chicken telencephalic cell cultures . Regulation ADAM11 CCL17 11876749 918939 Our study strongly suggests that serum [MDC] levels have a notable correlation with disease activity and that MDC , as well as the , may be *involved* in the pathogenesis of AD . Regulation ADAM11 EPHB2 17617806 1769783 The suppressive effect on [MDC] and IP-10 may , at least in part , *involve* the down-regulation of LPS induced p38 and expression . Regulation ADAM11 TLR7 17359388 1712648 [mDC] from atopic patients are not restricted in their *response* to . Regulation ADAM11 TNF 15474066 1318817 The *effects* of interleukin (IL)-2 , IL-4 , IL-5 , IL-10 , IL-12 , IL-13 , interferon-gamma (IFN-gamma) , and on the production of TARC and [MDC] were investigated . Regulation ADAM11 TNF 16094077 1443617 Previously we have reported that RT4 , a well differentiated human bladder cancer line , increases the expression of [macrophage derived chemokine (MDC)] and interferon (IFN)-gamma-inducible protein-10 ( IP-10 ) in *response* to IFN-gamma and . Regulation ADAM17 TNF 11120787 758198 Hence , [TACE] does not only *control* the release of , but also that of sCD30 . Regulation ADAM17 TNF 15556048 1340140 These observations suggest that TACE in PBMC is an important regulator of TNF-alpha maturation , meaning that [TACE] may be a potential *target* for the inhibition of cellular production in CHF . Regulation ADAM17 TNF 15603556 1380745 These results demonstrate that TACE mediated TNF-alpha maturation in PBMCs may play an important role in poor outcomes from AMI , suggesting that [TACE] may be a potential *target* for the inhibition of cellular production in AMI . Regulation ADAM17 TNF 15647744 1363632 In summary , these data show that IPC produces neuronal upregulation of [TACE] and TNFR1 , and that the pathway is *involved* in IT . Regulation ADAM8 CST6 20116077 2226772 While both enzymes are inhibited by E-64 and iodoacetamide , chicken fully inhibits CMS1MS2 , but scarcely *affects* activity of [CMS2MS2] . Regulation ADAMTS1 HDAC6 19007777 1998213 These data suggest the *involvement* of and SP1 in the HDACi induced expression of angiostatic [ADAMTS1] . Regulation ADAMTS1 IL1A 11311987 805189 These findings suggest that nerve injury promotes IL-1RT1 expression in the injured neurons and thereby [ADAMTS-1] transcription was induced in *response* to released from glial cells . Regulation ADAMTS1 IL1A 16949904 1673230 We further used a chondrosarcoma cell line to study the *effect* of and hypoxia on the regulation of [ADAMTS1] and VEGF-A expression . Regulation ADAMTS1 IL1B 16675485 1589772 Differential *effects* of and transforming growth factor-beta1 on the expression of the inflammation associated protein , [ADAMTS-1] , in human decidual stromal cells in vitro . Regulation ADAMTS1 IL1B 16675485 1589776 and TGF-beta1 differentially *regulate* [ADAMTS-1] expression in human decidual stromal cells . Regulation ADAMTS1 IL1B 16949904 1673228 [ADAMTS1] is *regulated* by , not by hypoxia , in chondrosarcoma . Regulation ADAMTS1 PGR 14664708 1177708 The tIssue distribution of the , a known *regulator* of [ADAMTS-1] expression in rodent preovulatory follicles , was found to overlap that of ADAMTS-1 in some tIssues . Regulation ADAMTS1 PTH 17560840 1767660 Here , we first establish that [ADAMTS-1] protein is rapidly and transiently produced by human primary osteoblasts in *response* to ( 1-34 ) . Regulation ADAMTS1 SP1 19007777 1998212 These data suggest the *involvement* of HDAC6 and in the HDACi induced expression of angiostatic [ADAMTS1] . Regulation ADAMTS1 TGFB1 15599946 1387556 The negative *effect* of on [ADAMTS-1] , -5 , -9 , and -15 coupled with increases in their inhibitor , TIMP-3 may aid the accumulation of versican in the stromal compartment of the prostate in BPH and prostate cancer . Regulation ADAMTS1 TGFB1 16675485 1589771 Differential *effects* of interleukin-1beta and on the expression of the inflammation associated protein , [ADAMTS-1] , in human decidual stromal cells in vitro . Regulation ADAMTS1 TGFB1 16675485 1589775 IL-1beta and differentially *regulate* [ADAMTS-1] expression in human decidual stromal cells . Regulation ADAMTS1 THBS1 20103648 2201973 The principal antiangiogenic activity of resides in a domain containing three TSP1 repeats ( 3TSR ) , and TSP1 cleavage is *regulated* , in part , by the metalloproteinase [ADAMTS1] . Regulation ADAMTS1 VEGFA 16936124 1608930 The purpose of this study was to investigate the expression of ADAMTS1 in endothelial cells and in a mouse model of ischemia induced retinal neovascularization and to study the *regulation* of [ADAMTS1] expression in endothelial cells by ( VEGF ) . Regulation ADAMTS13 TNF 23816135 2824695 IL-6 decreased ADAMTS13 expression , and had no significant *effects* on [ADAMTS13] expression in podocytes . Regulation ADAMTS4 EPHB2 23680829 2819342 Gene expression of [ADAMTS-4] , ADAMTS-5 , and TGF-b were not *affected* by IL-1 or inhibition . Regulation ADAMTS4 IL1B 19342688 2056851 The role and relative contribution of MyD88 , IRAK1 , and TRAF6 adaptor proteins in *regulation* of [aggrecanase-1] ( ADAMTS-4 ) is unknown . Regulation ADAMTS4 IL1B 19342688 2056882 These findings suggest that Ras , ROS along with MyD88 , IRAK1 , or TRAF6 synergistically mediate [ADAMTS-4] *regulation* by . Regulation ADAMTS4 TNF 23602832 2789744 We investigated and IL-1ß *regulation* of [ADAMTS-4] expression in nucleus pulposus ( NP ) cells and its role in aggrecan degradation . Regulation ADAMTS4 TNF 23602832 2789790 Lentiviral transduction with shRNA plasmids shp65 , shp52 , shIKK-a , and shIKK-ß significantly decreased *dependent* increase in [ADAMTS-4] and -5 levels and aggrecan degradation . Regulation ADAMTS4 TNF 24126638 2858875 In the present study , we explored the interaction between the two proteins by examining the *effect* of on [ADAMTS-4] expression and activity in osteoarthritic chondrocytes . Regulation ADAMTS4 TNF 24126638 2858877 SPD304 ( 50 µM ) and p38 mitogen activated protein kinase (MAPK) siRNA and inhibitor PD169316 ( 25 µM ) completely eradicated the promoting *effect* of on [ADAMTS-4] expression and activity . Regulation ADAMTS5 EPHB2 23680829 2819344 Gene expression of ADAMTS-4 , [ADAMTS-5] , and TGF-b were not *affected* by IL-1 or inhibition . Regulation ADAMTS5 IL1B 19035520 1998621 S100A8 significantly increased the *effect* of on MMP-3 , MMP-13 , and [ADAMTS-5] . Regulation ADAMTS5 TNF 19778432 2163663 increased matrix metalloproteinase (MMP)-3 and a disintegrin and metalloproteinase with thrombospondin motifs ( ADAMTS)-4 mRNA expression , whereas collagen type I was decreased , and aggrecan , collagen type II as well as MMP-1 , -2 , -13 and [ADAMTS-5] were variably *affected* . Regulation ADAMTS5 TNF 23602832 2789791 Lentiviral transduction with shRNA plasmids shp65 , shp52 , shIKK-a , and shIKK-ß significantly decreased *dependent* increase in [ADAMTS-4 and -5] levels and aggrecan degradation . Regulation ADCY1 ADRB2 1326677 197571 The effects of prostaglandin E2 ( PGE2 ) infusions on lymphocyte *dependent* [adenylate cyclase] ( beta 2ARAC ) system were studied in 26 patients with resistant hypertension ( RH ) . Regulation ADCY1 ADRB2 7809956 284951 [ The effect of sodium and ouabain on the activation of *dependent* [adenylate cyclase] in human lymphocytes ] . Regulation ADCY1 CABP4 947908 4025 *Regulation* of [adenylate cyclase] from glial tumor cells by calcium and a . Regulation ADCY1 CAPN8 10769177 685159 Calpain treatment potentiated the activity of guanosine 5'- [ gamma-thio ] triphosphate ( GTP [ S ] ) , but did not attenuate MnCl ( 2 ) action on adenylate cyclase , suggesting that *acted* at the G-protein level , rather than directly on [adenylate cyclase] . Regulation ADCY1 CAPN8 10769177 685299 Therefore the stimulatory *effect* of on [adenylate cyclase] is due to the cleavage of G ( s ) alpha in GH ( 4 ) C ( 1 ) cell membranes . Regulation ADCY1 CDKN1C 11880488 919442 Pituitary [adenylate cyclase] activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is *regulated* by dependent CDK2 activity . Regulation ADCY1 IL1B 3263120 100064 In the present study we evaluated the *effect* of on [adenylate cyclase] activity in 235-1 pituitary cell line . Regulation ADCY1 IL1B 3263120 100074 The dose-response curve of *effect* on [adenylate cyclase] activity showed a significant inhibition of basal enzyme activity at 1 pM concentration , while the inhibition of forskolin stimulated adenylate cyclase activity was more pronounced and evident at both 0.01 and 1 pM concentrations . Regulation ADCY1 IL1B 3263120 100084 The inhibitory *effect* of on [adenylate cyclase] activity disappeared , while the highest concentration of interleukin 1 beta tested , caused a meaningful stimulation of adenylate cyclase activity which is not present in acute condition . Regulation ADCY1 IL1B 7506523 239974 Calcitonin (CT) , substance P ( SP ) , , and transforming growth factor-beta 1 ( TGF beta 1 ) had no *effect* on [adenylate cyclase] in either fibroblast . Regulation ADCY1 SNCAIP 10875754 707313 did not *affect* the [adenylate cyclase] activities of the membrane preparations made from the right atrium and left ventricle . Regulation ADCY10 ADRB2 1326677 197570 The effects of prostaglandin E2 ( PGE2 ) infusions on lymphocyte *dependent* [adenylate cyclase] ( beta 2ARAC ) system were studied in 26 patients with resistant hypertension ( RH ) . Regulation ADCY10 ADRB2 7809956 284950 [ The effect of sodium and ouabain on the activation of *dependent* [adenylate cyclase] in human lymphocytes ] . Regulation ADCY10 CA12 3136415 95892 Ultrastructural localization of and its possible *role* in the endolymphatic [sac] . Regulation ADCY10 CABP4 947908 4020 *Regulation* of [adenylate cyclase] from glial tumor cells by calcium and a . Regulation ADCY10 CAPN8 10769177 685145 Calpain treatment potentiated the activity of guanosine 5'- [ gamma-thio ] triphosphate ( GTP [ S ] ) , but did not attenuate MnCl ( 2 ) action on adenylate cyclase , suggesting that *acted* at the G-protein level , rather than directly on [adenylate cyclase] . Regulation ADCY10 CAPN8 10769177 685285 Therefore the stimulatory *effect* of on [adenylate cyclase] is due to the cleavage of G ( s ) alpha in GH ( 4 ) C ( 1 ) cell membranes . Regulation ADCY10 CDKN1C 11880488 919440 Pituitary [adenylate cyclase] activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is *regulated* by dependent CDK2 activity . Regulation ADCY10 IL1B 3263120 100063 In the present study we evaluated the *effect* of on [adenylate cyclase] activity in 235-1 pituitary cell line . Regulation ADCY10 IL1B 3263120 100073 The dose-response curve of *effect* on [adenylate cyclase] activity showed a significant inhibition of basal enzyme activity at 1 pM concentration , while the inhibition of forskolin stimulated adenylate cyclase activity was more pronounced and evident at both 0.01 and 1 pM concentrations . Regulation ADCY10 IL1B 3263120 100083 The inhibitory *effect* of on [adenylate cyclase] activity disappeared , while the highest concentration of interleukin 1 beta tested , caused a meaningful stimulation of adenylate cyclase activity which is not present in acute condition . Regulation ADCY10 IL1B 7506523 239972 Calcitonin (CT) , substance P ( SP ) , , and transforming growth factor-beta 1 ( TGF beta 1 ) had no *effect* on [adenylate cyclase] in either fibroblast . Regulation ADCY10 SNCAIP 10875754 707312 did not *affect* the [adenylate cyclase] activities of the membrane preparations made from the right atrium and left ventricle . Regulation ADCY2 ADRB2 1326677 197572 The effects of prostaglandin E2 ( PGE2 ) infusions on lymphocyte *dependent* [adenylate cyclase] ( beta 2ARAC ) system were studied in 26 patients with resistant hypertension ( RH ) . Regulation ADCY2 ADRB2 7809956 284952 [ The effect of sodium and ouabain on the activation of *dependent* [adenylate cyclase] in human lymphocytes ] . Regulation ADCY2 CABP4 947908 4030 *Regulation* of [adenylate cyclase] from glial tumor cells by calcium and a . Regulation ADCY2 CAPN8 10769177 685173 Calpain treatment potentiated the activity of guanosine 5'- [ gamma-thio ] triphosphate ( GTP [ S ] ) , but did not attenuate MnCl ( 2 ) action on adenylate cyclase , suggesting that *acted* at the G-protein level , rather than directly on [adenylate cyclase] . Regulation ADCY2 CAPN8 10769177 685313 Therefore the stimulatory *effect* of on [adenylate cyclase] is due to the cleavage of G ( s ) alpha in GH ( 4 ) C ( 1 ) cell membranes . Regulation ADCY2 CDKN1C 11880488 919444 Pituitary [adenylate cyclase] activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is *regulated* by dependent CDK2 activity . Regulation ADCY2 IL1B 3263120 100065 In the present study we evaluated the *effect* of on [adenylate cyclase] activity in 235-1 pituitary cell line . Regulation ADCY2 IL1B 3263120 100075 The dose-response curve of *effect* on [adenylate cyclase] activity showed a significant inhibition of basal enzyme activity at 1 pM concentration , while the inhibition of forskolin stimulated adenylate cyclase activity was more pronounced and evident at both 0.01 and 1 pM concentrations . Regulation ADCY2 IL1B 3263120 100085 The inhibitory *effect* of on [adenylate cyclase] activity disappeared , while the highest concentration of interleukin 1 beta tested , caused a meaningful stimulation of adenylate cyclase activity which is not present in acute condition . Regulation ADCY2 IL1B 7506523 239976 Calcitonin (CT) , substance P ( SP ) , , and transforming growth factor-beta 1 ( TGF beta 1 ) had no *effect* on [adenylate cyclase] in either fibroblast . Regulation ADCY2 SNCAIP 10875754 707314 did not *affect* the [adenylate cyclase] activities of the membrane preparations made from the right atrium and left ventricle . Regulation ADCY3 ADRB2 1326677 197573 The effects of prostaglandin E2 ( PGE2 ) infusions on lymphocyte *dependent* [adenylate cyclase] ( beta 2ARAC ) system were studied in 26 patients with resistant hypertension ( RH ) . Regulation ADCY3 ADRB2 7809956 284953 [ The effect of sodium and ouabain on the activation of *dependent* [adenylate cyclase] in human lymphocytes ] . Regulation ADCY3 CABP4 947908 4035 *Regulation* of [adenylate cyclase] from glial tumor cells by calcium and a . Regulation ADCY3 CAPN8 10769177 685187 Calpain treatment potentiated the activity of guanosine 5'- [ gamma-thio ] triphosphate ( GTP [ S ] ) , but did not attenuate MnCl ( 2 ) action on adenylate cyclase , suggesting that *acted* at the G-protein level , rather than directly on [adenylate cyclase] . Regulation ADCY3 CAPN8 10769177 685327 Therefore the stimulatory *effect* of on [adenylate cyclase] is due to the cleavage of G ( s ) alpha in GH ( 4 ) C ( 1 ) cell membranes . Regulation ADCY3 CDKN1C 11880488 919446 Pituitary [adenylate cyclase] activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is *regulated* by dependent CDK2 activity . Regulation ADCY3 IL1B 3263120 100066 In the present study we evaluated the *effect* of on [adenylate cyclase] activity in 235-1 pituitary cell line . Regulation ADCY3 IL1B 3263120 100076 The dose-response curve of *effect* on [adenylate cyclase] activity showed a significant inhibition of basal enzyme activity at 1 pM concentration , while the inhibition of forskolin stimulated adenylate cyclase activity was more pronounced and evident at both 0.01 and 1 pM concentrations . Regulation ADCY3 IL1B 3263120 100086 The inhibitory *effect* of on [adenylate cyclase] activity disappeared , while the highest concentration of interleukin 1 beta tested , caused a meaningful stimulation of adenylate cyclase activity which is not present in acute condition . Regulation ADCY3 IL1B 7506523 239978 Calcitonin (CT) , substance P ( SP ) , , and transforming growth factor-beta 1 ( TGF beta 1 ) had no *effect* on [adenylate cyclase] in either fibroblast . Regulation ADCY3 SNCAIP 10875754 707315 did not *affect* the [adenylate cyclase] activities of the membrane preparations made from the right atrium and left ventricle . Regulation ADCY4 ADRB2 1326677 197574 The effects of prostaglandin E2 ( PGE2 ) infusions on lymphocyte *dependent* [adenylate cyclase] ( beta 2ARAC ) system were studied in 26 patients with resistant hypertension ( RH ) . Regulation ADCY4 ADRB2 7809956 284954 [ The effect of sodium and ouabain on the activation of *dependent* [adenylate cyclase] in human lymphocytes ] . Regulation ADCY4 CABP4 947908 4040 *Regulation* of [adenylate cyclase] from glial tumor cells by calcium and a . Regulation ADCY4 CAPN8 10769177 685201 Calpain treatment potentiated the activity of guanosine 5'- [ gamma-thio ] triphosphate ( GTP [ S ] ) , but did not attenuate MnCl ( 2 ) action on adenylate cyclase , suggesting that *acted* at the G-protein level , rather than directly on [adenylate cyclase] . Regulation ADCY4 CAPN8 10769177 685341 Therefore the stimulatory *effect* of on [adenylate cyclase] is due to the cleavage of G ( s ) alpha in GH ( 4 ) C ( 1 ) cell membranes . Regulation ADCY4 CDKN1C 11880488 919448 Pituitary [adenylate cyclase] activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is *regulated* by dependent CDK2 activity . Regulation ADCY4 IL1B 3263120 100067 In the present study we evaluated the *effect* of on [adenylate cyclase] activity in 235-1 pituitary cell line . Regulation ADCY4 IL1B 3263120 100077 The dose-response curve of *effect* on [adenylate cyclase] activity showed a significant inhibition of basal enzyme activity at 1 pM concentration , while the inhibition of forskolin stimulated adenylate cyclase activity was more pronounced and evident at both 0.01 and 1 pM concentrations . Regulation ADCY4 IL1B 3263120 100087 The inhibitory *effect* of on [adenylate cyclase] activity disappeared , while the highest concentration of interleukin 1 beta tested , caused a meaningful stimulation of adenylate cyclase activity which is not present in acute condition . Regulation ADCY4 IL1B 7506523 239980 Calcitonin (CT) , substance P ( SP ) , , and transforming growth factor-beta 1 ( TGF beta 1 ) had no *effect* on [adenylate cyclase] in either fibroblast . Regulation ADCY4 SNCAIP 10875754 707316 did not *affect* the [adenylate cyclase] activities of the membrane preparations made from the right atrium and left ventricle . Regulation ADCY5 ADRB2 1326677 197575 The effects of prostaglandin E2 ( PGE2 ) infusions on lymphocyte *dependent* [adenylate cyclase] ( beta 2ARAC ) system were studied in 26 patients with resistant hypertension ( RH ) . Regulation ADCY5 ADRB2 7809956 284955 [ The effect of sodium and ouabain on the activation of *dependent* [adenylate cyclase] in human lymphocytes ] . Regulation ADCY5 CABP4 947908 4045 *Regulation* of [adenylate cyclase] from glial tumor cells by calcium and a . Regulation ADCY5 CAPN8 10769177 685215 Calpain treatment potentiated the activity of guanosine 5'- [ gamma-thio ] triphosphate ( GTP [ S ] ) , but did not attenuate MnCl ( 2 ) action on adenylate cyclase , suggesting that *acted* at the G-protein level , rather than directly on [adenylate cyclase] . Regulation ADCY5 CAPN8 10769177 685355 Therefore the stimulatory *effect* of on [adenylate cyclase] is due to the cleavage of G ( s ) alpha in GH ( 4 ) C ( 1 ) cell membranes . Regulation ADCY5 CDKN1C 11880488 919450 Pituitary [adenylate cyclase] activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is *regulated* by dependent CDK2 activity . Regulation ADCY5 IL1B 3263120 100068 In the present study we evaluated the *effect* of on [adenylate cyclase] activity in 235-1 pituitary cell line . Regulation ADCY5 IL1B 3263120 100078 The dose-response curve of *effect* on [adenylate cyclase] activity showed a significant inhibition of basal enzyme activity at 1 pM concentration , while the inhibition of forskolin stimulated adenylate cyclase activity was more pronounced and evident at both 0.01 and 1 pM concentrations . Regulation ADCY5 IL1B 3263120 100088 The inhibitory *effect* of on [adenylate cyclase] activity disappeared , while the highest concentration of interleukin 1 beta tested , caused a meaningful stimulation of adenylate cyclase activity which is not present in acute condition . Regulation ADCY5 IL1B 7506523 239982 Calcitonin (CT) , substance P ( SP ) , , and transforming growth factor-beta 1 ( TGF beta 1 ) had no *effect* on [adenylate cyclase] in either fibroblast . Regulation ADCY5 SNCAIP 10875754 707317 did not *affect* the [adenylate cyclase] activities of the membrane preparations made from the right atrium and left ventricle . Regulation ADCY6 ADRB2 1326677 197576 The effects of prostaglandin E2 ( PGE2 ) infusions on lymphocyte *dependent* [adenylate cyclase] ( beta 2ARAC ) system were studied in 26 patients with resistant hypertension ( RH ) . Regulation ADCY6 ADRB2 7809956 284956 [ The effect of sodium and ouabain on the activation of *dependent* [adenylate cyclase] in human lymphocytes ] . Regulation ADCY6 CABP4 947908 4050 *Regulation* of [adenylate cyclase] from glial tumor cells by calcium and a . Regulation ADCY6 CAPN8 10769177 685229 Calpain treatment potentiated the activity of guanosine 5'- [ gamma-thio ] triphosphate ( GTP [ S ] ) , but did not attenuate MnCl ( 2 ) action on adenylate cyclase , suggesting that *acted* at the G-protein level , rather than directly on [adenylate cyclase] . Regulation ADCY6 CAPN8 10769177 685369 Therefore the stimulatory *effect* of on [adenylate cyclase] is due to the cleavage of G ( s ) alpha in GH ( 4 ) C ( 1 ) cell membranes . Regulation ADCY6 CDKN1C 11880488 919452 Pituitary [adenylate cyclase] activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is *regulated* by dependent CDK2 activity . Regulation ADCY6 IL1B 3263120 100069 In the present study we evaluated the *effect* of on [adenylate cyclase] activity in 235-1 pituitary cell line . Regulation ADCY6 IL1B 3263120 100079 The dose-response curve of *effect* on [adenylate cyclase] activity showed a significant inhibition of basal enzyme activity at 1 pM concentration , while the inhibition of forskolin stimulated adenylate cyclase activity was more pronounced and evident at both 0.01 and 1 pM concentrations . Regulation ADCY6 IL1B 3263120 100089 The inhibitory *effect* of on [adenylate cyclase] activity disappeared , while the highest concentration of interleukin 1 beta tested , caused a meaningful stimulation of adenylate cyclase activity which is not present in acute condition . Regulation ADCY6 IL1B 7506523 239984 Calcitonin (CT) , substance P ( SP ) , , and transforming growth factor-beta 1 ( TGF beta 1 ) had no *effect* on [adenylate cyclase] in either fibroblast . Regulation ADCY6 SNCAIP 10875754 707318 did not *affect* the [adenylate cyclase] activities of the membrane preparations made from the right atrium and left ventricle . Regulation ADCY7 ADRB2 1326677 197577 The effects of prostaglandin E2 ( PGE2 ) infusions on lymphocyte *dependent* [adenylate cyclase] ( beta 2ARAC ) system were studied in 26 patients with resistant hypertension ( RH ) . Regulation ADCY7 ADRB2 7809956 284957 [ The effect of sodium and ouabain on the activation of *dependent* [adenylate cyclase] in human lymphocytes ] . Regulation ADCY7 CABP4 947908 4055 *Regulation* of [adenylate cyclase] from glial tumor cells by calcium and a . Regulation ADCY7 CAPN8 10769177 685243 Calpain treatment potentiated the activity of guanosine 5'- [ gamma-thio ] triphosphate ( GTP [ S ] ) , but did not attenuate MnCl ( 2 ) action on adenylate cyclase , suggesting that *acted* at the G-protein level , rather than directly on [adenylate cyclase] . Regulation ADCY7 CAPN8 10769177 685383 Therefore the stimulatory *effect* of on [adenylate cyclase] is due to the cleavage of G ( s ) alpha in GH ( 4 ) C ( 1 ) cell membranes . Regulation ADCY7 CDKN1C 11880488 919454 Pituitary [adenylate cyclase] activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is *regulated* by dependent CDK2 activity . Regulation ADCY7 IL1B 3263120 100070 In the present study we evaluated the *effect* of on [adenylate cyclase] activity in 235-1 pituitary cell line . Regulation ADCY7 IL1B 3263120 100080 The dose-response curve of *effect* on [adenylate cyclase] activity showed a significant inhibition of basal enzyme activity at 1 pM concentration , while the inhibition of forskolin stimulated adenylate cyclase activity was more pronounced and evident at both 0.01 and 1 pM concentrations . Regulation ADCY7 IL1B 3263120 100090 The inhibitory *effect* of on [adenylate cyclase] activity disappeared , while the highest concentration of interleukin 1 beta tested , caused a meaningful stimulation of adenylate cyclase activity which is not present in acute condition . Regulation ADCY7 IL1B 7506523 239986 Calcitonin (CT) , substance P ( SP ) , , and transforming growth factor-beta 1 ( TGF beta 1 ) had no *effect* on [adenylate cyclase] in either fibroblast . Regulation ADCY7 SNCAIP 10875754 707319 did not *affect* the [adenylate cyclase] activities of the membrane preparations made from the right atrium and left ventricle . Regulation ADCY8 ADRB2 1326677 197578 The effects of prostaglandin E2 ( PGE2 ) infusions on lymphocyte *dependent* [adenylate cyclase] ( beta 2ARAC ) system were studied in 26 patients with resistant hypertension ( RH ) . Regulation ADCY8 ADRB2 7809956 284958 [ The effect of sodium and ouabain on the activation of *dependent* [adenylate cyclase] in human lymphocytes ] . Regulation ADCY8 CABP4 947908 4060 *Regulation* of [adenylate cyclase] from glial tumor cells by calcium and a . Regulation ADCY8 CAPN8 10769177 685257 Calpain treatment potentiated the activity of guanosine 5'- [ gamma-thio ] triphosphate ( GTP [ S ] ) , but did not attenuate MnCl ( 2 ) action on adenylate cyclase , suggesting that *acted* at the G-protein level , rather than directly on [adenylate cyclase] . Regulation ADCY8 CAPN8 10769177 685397 Therefore the stimulatory *effect* of on [adenylate cyclase] is due to the cleavage of G ( s ) alpha in GH ( 4 ) C ( 1 ) cell membranes . Regulation ADCY8 CDKN1C 11880488 919456 Pituitary [adenylate cyclase] activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is *regulated* by dependent CDK2 activity . Regulation ADCY8 IL1B 3263120 100071 In the present study we evaluated the *effect* of on [adenylate cyclase] activity in 235-1 pituitary cell line . Regulation ADCY8 IL1B 3263120 100081 The dose-response curve of *effect* on [adenylate cyclase] activity showed a significant inhibition of basal enzyme activity at 1 pM concentration , while the inhibition of forskolin stimulated adenylate cyclase activity was more pronounced and evident at both 0.01 and 1 pM concentrations . Regulation ADCY8 IL1B 3263120 100091 The inhibitory *effect* of on [adenylate cyclase] activity disappeared , while the highest concentration of interleukin 1 beta tested , caused a meaningful stimulation of adenylate cyclase activity which is not present in acute condition . Regulation ADCY8 IL1B 7506523 239988 Calcitonin (CT) , substance P ( SP ) , , and transforming growth factor-beta 1 ( TGF beta 1 ) had no *effect* on [adenylate cyclase] in either fibroblast . Regulation ADCY8 SNCAIP 10875754 707320 did not *affect* the [adenylate cyclase] activities of the membrane preparations made from the right atrium and left ventricle . Regulation ADCY9 ADRB2 1326677 197579 The effects of prostaglandin E2 ( PGE2 ) infusions on lymphocyte *dependent* [adenylate cyclase] ( beta 2ARAC ) system were studied in 26 patients with resistant hypertension ( RH ) . Regulation ADCY9 ADRB2 7809956 284959 [ The effect of sodium and ouabain on the activation of *dependent* [adenylate cyclase] in human lymphocytes ] . Regulation ADCY9 CABP4 947908 4065 *Regulation* of [adenylate cyclase] from glial tumor cells by calcium and a . Regulation ADCY9 CAPN8 10769177 685271 Calpain treatment potentiated the activity of guanosine 5'- [ gamma-thio ] triphosphate ( GTP [ S ] ) , but did not attenuate MnCl ( 2 ) action on adenylate cyclase , suggesting that *acted* at the G-protein level , rather than directly on [adenylate cyclase] . Regulation ADCY9 CAPN8 10769177 685411 Therefore the stimulatory *effect* of on [adenylate cyclase] is due to the cleavage of G ( s ) alpha in GH ( 4 ) C ( 1 ) cell membranes . Regulation ADCY9 CDKN1C 11880488 919458 Pituitary [adenylate cyclase] activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is *regulated* by dependent CDK2 activity . Regulation ADCY9 IL1B 3263120 100072 In the present study we evaluated the *effect* of on [adenylate cyclase] activity in 235-1 pituitary cell line . Regulation ADCY9 IL1B 3263120 100082 The dose-response curve of *effect* on [adenylate cyclase] activity showed a significant inhibition of basal enzyme activity at 1 pM concentration , while the inhibition of forskolin stimulated adenylate cyclase activity was more pronounced and evident at both 0.01 and 1 pM concentrations . Regulation ADCY9 IL1B 3263120 100092 The inhibitory *effect* of on [adenylate cyclase] activity disappeared , while the highest concentration of interleukin 1 beta tested , caused a meaningful stimulation of adenylate cyclase activity which is not present in acute condition . Regulation ADCY9 IL1B 7506523 239990 Calcitonin (CT) , substance P ( SP ) , , and transforming growth factor-beta 1 ( TGF beta 1 ) had no *effect* on [adenylate cyclase] in either fibroblast . Regulation ADCY9 SNCAIP 10875754 707321 did not *affect* the [adenylate cyclase] activities of the membrane preparations made from the right atrium and left ventricle . Regulation ADCYAP1 EPHB2 11453643 837030 These results indicate that PACAP receptors are coupled to the p38 signaling pathway , and that p38 plays a key role in the regulation of PACAP gene expression , while , but not p38 , MAPK is *involved* in [PACAP] and NGF induced neurite outgrowth . Regulation ADCYAP1 IL1B 17683829 1794177 Therefore , we first tested the *effects* of peripheral on VIP and [PACAP] central production . Regulation ADH1B ALDH2 22703580 2659339 [ADH1B*2] is involved in overproduction of acetaldehyde due to increased ethanol metabolism into acetaldehyde , and is *involved* in accumulation of acetaldehyde due to the deficiency of acetaldehyde metabolism . Regulation ADH5 ADH1C 11073833 748799 Because formaldehyde exposure has been shown to induce pathological changes in human oral mucosa , eg , micronuclei , the potential enzymatic defense by *dependent* [formaldehyde dehydrogenase] was characterized in oral tissue specimens and cell lines using RNA hybridization and immunological methods as well as enzyme activity measurements . Regulation ADIPOQ MAP2K6 23490586 2818605 Adipose tissue activity can differentially *regulate* [adiponectin] gene expression and protein abundance and its suppression in obesity may play a mechanistic role in obesity related plasma adiponectin decline . Regulation ADIPOQ TNF 11798186 902323 Moreover , the negative *effects* of insulin , , and dexamethasone on [adiponectin] gene expression could be completely reversed by withdrawal of the hormones for 24 h. Taken together , our results suggest that adiponectin gene expression is reversibly downregulated by insulin , TNFalpha , and dexamethasone . Regulation ADIPOQ TNF 15629137 1362202 In the present study , the mechanism by which [adiponectin] is *regulated* by was investigated . Regulation ADIPOQ TNF 15705753 1372760 and 3 ) to study , in stromal-vascular cell culture , the *effects* of leptin and on pig [adiponectin] , adipoR1 , and adipoR2 gene expression . Regulation ADIPOQ TNF 15850785 1399363 The aims of the present study were : ( 1 ) to identify the promoter region responsible for basal transcription of the human adiponectin gene , and ( 2 ) to investigate the mechanism by which [adiponectin] was *regulated* by . Regulation ADIPOQ TNF 17447161 1729909 To identify new regulatory mechanisms in fat , the *effect* of ( TNF ) on [adiponectin] , on its two receptors , and on visfatin was investigated by incubating human visceral adipose tissue from patients without diabetes mellitus with TNF for 24 , 48 and 72 hours . Regulation ADIPOQ TNF 17929130 1813355 Our study shows a short-term efficacy of infliximab on adiponectin levels and endothelial dysfunction of patients with RA , and provides additional evidence to support the regulatory *role* of on the expression of [adiponectin] in vivo . Regulation ADIPOQ TNF 20089616 2206067 The net change in [adiponectin] secretion in *response* to IL-6 , monocyte chemoattractant protein-1 , and differed between PCOS ( decreasing ) and control ( increasing ) adipocytes , although the difference reached significance only for TNF-alpha ( P < 0.04 ) . Regulation ADIPOQ TNF 20382515 2315325 In addition , EERP attenuated the inhibitory *effect* of on adipocyte differentiation and [adiponectin] production in mature adipocytes . Regulation ADIPOQ TNF 20382515 2315326 The present study indicates that EERP enhance differentiation of 3T3-L1 adipocytes in part by its potency of PPAR? activation and are capable of reversing inhibitory *effects* of on adipocyte differentiation and [adiponectin] expression . Regulation ADIPOQ TNF 22658637 2643604 Our findings suggested that simvastatin counteracted the stimulatory *effect* of on secretion and expression of MCP-1 , PAI-1 and [adiponectin] , implying a potential anti-atherogenic effect during the inflammatory process ; Regulation ADIPOR2 FOXO1 21194380 2443139 *Role* of signaling in dietary saturated fat dependent upregulation of liver [adiponectin receptor 2] in ethanol administered mice . Regulation ADM EDN2 11549285 856787 *Effects* of on [adrenomedullin] secretion and expression of adrenomedullin receptors in rat cardiomyocytes . Regulation ADM IL1B 11799096 902408 For this purpose , we characterized the *effects* of inflammatory cytokines , tumor necrosis factor-alpha ( 100 microg/L ) , ( 20 microg/L ) , and interferon-gamma ( 0.5 U/L ) on [ADM] gene expression in rat aortic vascular smooth muscle cells ( AVSMCs ) . Regulation ADM IL1B 15930287 1414478 Finally , treatment of HIF-1alpha with short interfering RNA revealed a significant role for HIF-1 in the *dependent* stimulation of [ADM] expression . Regulation ADM TNF 11799096 902406 For this purpose , we characterized the *effects* of inflammatory cytokines , ( 100 microg/L ) , interleukin-1beta ( 20 microg/L ) , and interferon-gamma ( 0.5 U/L ) on [ADM] gene expression in rat aortic vascular smooth muscle cells ( AVSMCs ) . Regulation ADM TNF 16622024 1551537 [ADM] secretion was *regulated* by . Regulation ADM TNF 22956308 2726590 The *effects* of and EDN-1 on [ADM] gene expression and secretion were also investigated . Regulation ADORA1 EPHB2 15485865 1342619 G16 mediated activation of nuclear factor kappaB by the [adenosine A1 receptor] *involves* c-Src , protein kinase C , and signaling . Regulation ADORA2A TNF 17082635 1643349 IL-1 beta and *regulation* of the [adenosine receptor (A2A)] expression : differential requirement for NF-kappa B binding to the proximal promoter . Regulation ADORA2B NT5E 24262796 2916600 Taken together , these findings implicate *dependent* production of extracellular adenosine and endothelial [Adora2b] signaling in kidney protection during diabetic nephropathy . Regulation ADRA2B GPR115 16533872 1561778 *Involvement* of 3 and GRK2 in down-regulation of the [alpha2B-adrenoceptor] . Regulation ADRA2B GPR132 16533872 1561767 *Involvement* of 3 and GRK2 in down-regulation of the [alpha2B-adrenoceptor] . Regulation ADRA2B GPR87 16533872 1561848 *Involvement* of 3 and GRK2 in down-regulation of the [alpha2B-adrenoceptor] . Regulation ADRB2 ADCY6 15381636 1304152 *Effect* of overexpressed on beta 1- and [beta 2-adrenoceptor] responses in adult rat ventricular myocytes . Regulation ADRB2 EGF 12540376 1071407 Moreover , the stimulatory *effect* of on [beta(2)-adrenergic receptor] signaling appears to be mediated by the MAPK pathway and independent of PKC activation . Regulation ADRB2 EGF 15459114 1354530 did not *affect* cellular levels of the [beta2-adrenoceptor] . Regulation ADRB2 GRAP2 19047375 2023505 Stimulation of the [beta(2)-adrenergic receptor] ( beta ( 2 ) AR ) on a CD40L/interleukin-4 activated B lymphocyte increases the level of immunoglobulin E ( IgE ) in a protein kinase A (PKA)- and mitogen activated protein kinase (MAPK) *dependent* manner . Regulation ADRB2 GRK1 11861327 917129 In light of data obtained in this study , we propose that both the decrease in AC activity and the increase in activity , which are reversed by dexamethasone , may *underlie* [beta(2)-adrenoceptor] desensitization . Regulation ADRB2 GRK1 20098494 2201886 We developed a unified model of the mediated [beta2 adrenergic receptor (beta2AR)] *regulation* that simultaneously accounts for six different biochemical measurements of the system obtained over a wide range of agonist concentrations . Regulation ADRB2 GRK4 11861327 917131 In light of data obtained in this study , we propose that both the decrease in AC activity and the increase in activity , which are reversed by dexamethasone , may *underlie* [beta(2)-adrenoceptor] desensitization . Regulation ADRB2 GRK4 20098494 2201888 We developed a unified model of the mediated [beta2 adrenergic receptor (beta2AR)] *regulation* that simultaneously accounts for six different biochemical measurements of the system obtained over a wide range of agonist concentrations . Regulation ADRB2 GRK5 11861327 917132 In light of data obtained in this study , we propose that both the decrease in AC activity and the increase in activity , which are reversed by dexamethasone , may *underlie* [beta(2)-adrenoceptor] desensitization . Regulation ADRB2 GRK5 20098494 2201889 We developed a unified model of the mediated [beta2 adrenergic receptor (beta2AR)] *regulation* that simultaneously accounts for six different biochemical measurements of the system obtained over a wide range of agonist concentrations . Regulation ADRB2 GRK6 11861327 917133 In light of data obtained in this study , we propose that both the decrease in AC activity and the increase in activity , which are reversed by dexamethasone , may *underlie* [beta(2)-adrenoceptor] desensitization . Regulation ADRB2 GRK6 20098494 2201890 We developed a unified model of the mediated [beta2 adrenergic receptor (beta2AR)] *regulation* that simultaneously accounts for six different biochemical measurements of the system obtained over a wide range of agonist concentrations . Regulation ADRB2 GRK7 11861327 917130 In light of data obtained in this study , we propose that both the decrease in AC activity and the increase in activity , which are reversed by dexamethasone , may *underlie* [beta(2)-adrenoceptor] desensitization . Regulation ADRB2 GRK7 20098494 2201887 We developed a unified model of the mediated [beta2 adrenergic receptor (beta2AR)] *regulation* that simultaneously accounts for six different biochemical measurements of the system obtained over a wide range of agonist concentrations . Regulation ADRB2 IL10 1324243 194965 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL11 1324243 194966 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL13 1324243 194967 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL15 1324243 194968 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL16 1324243 194969 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL18 1324243 194970 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL19 1324243 194971 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL1B 15833737 1417990 differentially *regulates* [beta2 adrenoreceptor] and prostaglandin E2-mediated cAMP accumulation and chloride efflux from Calu-3 bronchial epithelial cells . Regulation ADRB2 IL2 1324243 194972 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL20 1324243 194973 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL21 1324243 194974 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL22 1324243 194957 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL24 1324243 194955 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL25 1324243 194956 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL26 1324243 194961 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL27 1324243 194962 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL3 1324243 194975 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL31 1324243 194963 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL32 1324243 194960 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL33 1324243 194959 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL34 1324243 194964 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL37 1324243 194958 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL4 1324243 194976 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL5 1324243 194977 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL6 1324243 194978 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL7 1324243 194979 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL8 1324243 194980 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 IL9 1324243 194981 Selective *regulation* of [beta 2-adrenergic receptor] gene expression by in cultured human lung tumor cells . Regulation ADRB2 INS 11809767 928866 Akt mediates sequestration of the [beta(2)-adrenergic receptor] in *response* to . Regulation ADRB2 MAGI3 20353789 2260865 [Beta-2 adrenergic receptor] mediated ERK activation is *regulated* by interaction with . Regulation ADRB2 MAPK1 19047375 2023506 Stimulation of the [beta(2)-adrenergic receptor] ( beta ( 2 ) AR ) on a CD40L/interleukin-4 activated B lymphocyte increases the level of immunoglobulin E ( IgE ) in a protein kinase A (PKA)- and p38 *dependent* manner . Regulation ADRB2 MAPK10 19047375 2023507 Stimulation of the [beta(2)-adrenergic receptor] ( beta ( 2 ) AR ) on a CD40L/interleukin-4 activated B lymphocyte increases the level of immunoglobulin E ( IgE ) in a protein kinase A (PKA)- and p38 *dependent* manner . Regulation ADRB2 MAPK11 19047375 2023508 Stimulation of the [beta(2)-adrenergic receptor] ( beta ( 2 ) AR ) on a CD40L/interleukin-4 activated B lymphocyte increases the level of immunoglobulin E ( IgE ) in a protein kinase A (PKA)- and p38 *dependent* manner . Regulation ADRB2 MAPK12 19047375 2023509 Stimulation of the [beta(2)-adrenergic receptor] ( beta ( 2 ) AR ) on a CD40L/interleukin-4 activated B lymphocyte increases the level of immunoglobulin E ( IgE ) in a protein kinase A (PKA)- and p38 *dependent* manner . Regulation ADRB2 MAPK13 19047375 2023510 Stimulation of the [beta(2)-adrenergic receptor] ( beta ( 2 ) AR ) on a CD40L/interleukin-4 activated B lymphocyte increases the level of immunoglobulin E ( IgE ) in a protein kinase A (PKA)- and p38 *dependent* manner . Regulation ADRB2 MAPK14 19047375 2023511 Stimulation of the [beta(2)-adrenergic receptor] ( beta ( 2 ) AR ) on a CD40L/interleukin-4 activated B lymphocyte increases the level of immunoglobulin E ( IgE ) in a protein kinase A (PKA)- and p38 *dependent* manner . Regulation ADRB2 MAPK15 19047375 2023504 Stimulation of the [beta(2)-adrenergic receptor] ( beta ( 2 ) AR ) on a CD40L/interleukin-4 activated B lymphocyte increases the level of immunoglobulin E ( IgE ) in a protein kinase A (PKA)- and p38 *dependent* manner . Regulation ADRB2 MAPK3 19047375 2023512 Stimulation of the [beta(2)-adrenergic receptor] ( beta ( 2 ) AR ) on a CD40L/interleukin-4 activated B lymphocyte increases the level of immunoglobulin E ( IgE ) in a protein kinase A (PKA)- and p38 *dependent* manner . Regulation ADRB2 MAPK4 19047375 2023513 Stimulation of the [beta(2)-adrenergic receptor] ( beta ( 2 ) AR ) on a CD40L/interleukin-4 activated B lymphocyte increases the level of immunoglobulin E ( IgE ) in a protein kinase A (PKA)- and p38 *dependent* manner . Regulation ADRB2 MAPK6 19047375 2023514 Stimulation of the [beta(2)-adrenergic receptor] ( beta ( 2 ) AR ) on a CD40L/interleukin-4 activated B lymphocyte increases the level of immunoglobulin E ( IgE ) in a protein kinase A (PKA)- and p38 *dependent* manner . Regulation ADRB2 MAPK7 19047375 2023515 Stimulation of the [beta(2)-adrenergic receptor] ( beta ( 2 ) AR ) on a CD40L/interleukin-4 activated B lymphocyte increases the level of immunoglobulin E ( IgE ) in a protein kinase A (PKA)- and p38 *dependent* manner . Regulation ADRB2 MAPK8 19047375 2023516 Stimulation of the [beta(2)-adrenergic receptor] ( beta ( 2 ) AR ) on a CD40L/interleukin-4 activated B lymphocyte increases the level of immunoglobulin E ( IgE ) in a protein kinase A (PKA)- and p38 *dependent* manner . Regulation ADRB2 MAPK9 19047375 2023517 Stimulation of the [beta(2)-adrenergic receptor] ( beta ( 2 ) AR ) on a CD40L/interleukin-4 activated B lymphocyte increases the level of immunoglobulin E ( IgE ) in a protein kinase A (PKA)- and p38 *dependent* manner . Regulation ADRB2 OXTR 9584840 504448 [Beta2-adrenoceptor] desensitization in non-pregnant estrogen primed rat myometrium *involves* modulation of gene expression . Regulation ADRB2 PRKACB 9918542 587657 In attempting to characterize the *role* of in regulating the [beta-2 adrenergic receptor (AR)] in human airway cells , we observed a seemingly profound capacity of the isoquinoline H-89 , a potent and widely used PKA inhibitor , to attenuate agonist mediated desensitization of the beta-2 AR . Regulation ADRB2 PRKACG 9918542 587658 In attempting to characterize the *role* of in regulating the [beta-2 adrenergic receptor (AR)] in human airway cells , we observed a seemingly profound capacity of the isoquinoline H-89 , a potent and widely used PKA inhibitor , to attenuate agonist mediated desensitization of the beta-2 AR . Regulation ADRB2 PRKAR1A 9918542 587659 In attempting to characterize the *role* of in regulating the [beta-2 adrenergic receptor (AR)] in human airway cells , we observed a seemingly profound capacity of the isoquinoline H-89 , a potent and widely used PKA inhibitor , to attenuate agonist mediated desensitization of the beta-2 AR . Regulation ADRB2 PRKAR1B 9918542 587660 In attempting to characterize the *role* of in regulating the [beta-2 adrenergic receptor (AR)] in human airway cells , we observed a seemingly profound capacity of the isoquinoline H-89 , a potent and widely used PKA inhibitor , to attenuate agonist mediated desensitization of the beta-2 AR . Regulation ADRB2 PRKAR2A 9918542 587661 In attempting to characterize the *role* of in regulating the [beta-2 adrenergic receptor (AR)] in human airway cells , we observed a seemingly profound capacity of the isoquinoline H-89 , a potent and widely used PKA inhibitor , to attenuate agonist mediated desensitization of the beta-2 AR . Regulation ADRB2 PRKAR2B 9918542 587662 In attempting to characterize the *role* of in regulating the [beta-2 adrenergic receptor (AR)] in human airway cells , we observed a seemingly profound capacity of the isoquinoline H-89 , a potent and widely used PKA inhibitor , to attenuate agonist mediated desensitization of the beta-2 AR . Regulation ADRB2 SRC 14990578 1243147 Here we used mouse embryonic fibroblast (MEF) cells deficient in Src family tyrosine kinases to examine the *role* of in [beta2-adrenergic receptor] signaling to the MAPK pathway and in receptor internalization . Regulation ADRB2 TNF 8387402 217980 The *effect* of on lymphocyte [beta 2-adrenergic receptor] response is reported . Regulation ADRB2 UPP1 12792671 1097817 The inhibitory GABA(A) receptor , alpha1 glycine receptor , [beta(2)-adrenergic receptor] and arrestin , opiate receptors and the excitatory metabotropic glutamate receptor ( mGluR1alpha ) are *regulated* by the . Regulation ADRB2 UPP2 12792671 1097818 The inhibitory GABA(A) receptor , alpha1 glycine receptor , [beta(2)-adrenergic receptor] and arrestin , opiate receptors and the excitatory metabotropic glutamate receptor ( mGluR1alpha ) are *regulated* by the . Regulation ADRBK1 CAPN8 12130691 966711 Moreover , our data demonstrate that oxidative stress may change the functioning of GPCRs via *dependent* regulation of [GRK2] levels . Regulation ADRBK1 EPHB2 10629859 576456 In contrast with H2O2 induced activation of , the activation of ERK induced by phorbol ester PMA and the activation of JNK and p38 induced by H2O2 were not *affected* by expression of [GRK2-ct] , indicating that the activation of ERK but not JNK and p38 is dependent on beta gamma subunit . Regulation ADRBK1 GPR115 20147541 2208312 [GRK2] *regulates* cellular signaling by promoting desensitization and direct interaction with downstream kinases including p38 . Regulation ADRBK1 GPR132 20147541 2208301 [GRK2] *regulates* cellular signaling by promoting desensitization and direct interaction with downstream kinases including p38 . Regulation ADRBK1 GPR87 20147541 2208381 [GRK2] *regulates* cellular signaling by promoting desensitization and direct interaction with downstream kinases including p38 . Regulation ADRBK1 MIP 12592402 1064319 We also show that lipopolysaccharide (LPS) activated signaling through the Toll-like receptor (TLR)-4 pathway transcriptionally downregulates the expression of [GRK2] and GRK5 in *response* to . Regulation ADRBK1 TNF 16385076 1533413 C2-ceramide , a downstream mediator in the sphingomyelinase ( SMase ) -dependent pathway , mimicked the *effect* of on [GRK2] translocation . Regulation ADRBK1 TNF 16385076 1533415 Moreover , inhibitors of the SMases and an inhibitor of c-Jun NH2-terminal kinase , also a downstream effector in the SMase pathway , reversed mediated *effects* on [GRK2] translocation and A2A R desensitization . Regulation AFP TCN1 20087354 2206045 [Anti-AFP] *responses* were detected in 28.5 % of controls , as well as in 25 % of HCC patients with Okuda I ( early tumour stage ) and in 31.6 % of HCC patients with stage II or III ( late tumour stages ) . Regulation AFP TCN1 20087354 2206055 These results suggest that anti-AFP Th1 responses are more likely to be present in patients who are in an early stage of disease ( for both tumour stage and liver cirrhosis ) , whereas [anti-AFP] *responses* are more likely to be present in patients with late-stage liver cirrhosis . Regulation AGR2 ADI1 20097405 2219173 The results indicate that an [AGR] of 10t H ( 2 ) SO ( 4 ) /ha/year is conservative and a suitable cover design *target* for control that would be matched by ANRnc . Regulation AGR2 CD79A 1937766 170365 At least two to three intragastric doses of 15 micrograms or more of Ag I/II-CTB conjugate , plus free CT as an adjuvant , were needed to induce the salivary [anti-Ag I/II] *response* , which peaked at about 35 days and persisted at lower levels for 5 to 6 months . Regulation AGR2 CD79A 8418053 210476 induced stronger initial antibody responses to [AgI/II] in both serum and saliva than immunization i.g. , but salivary antibody *responses* to immunization about 3 months later were not increased relative to total salivary IgA concentrations . Regulation AGR2 CDC25C 15062106 1230731 In this context , the only known cell cycle component that responds to the Notch pathway is ( Stg ) , [a G2/M] cell cycle *regulator* . Regulation AGR2 PTPRC 1431097 202782 Based on this observation , experiments were designed to examine the *role* of in regulation of [AgR] complex phosphorylation . Regulation AGR2 S100A6 14585681 1159260 Intranasal immunizations of adult mice with strain 638 expressing [Ag2/PRA] induced serum vibriocidal antibody response to the vector strain and serum total IgG *response* to . Regulation AGR2 SETD2 23712868 2870494 [AGR2] expression is *regulated* by and contributes to growth and angiogenesis of glioblastoma . Regulation AGR2 SETD2 23712868 2870498 Taken together , these results indicate that [AGR2] expression is *regulated* by and plays an important role in control of glioblastoma growth and vascularity . Regulation AGR2 SST 2902147 98913 The acute insulin response ( AIR ) to 2.5 g of arginine during this infusion of epinephrine was significantly higher ( P less than 0.05 ) than in controls as were the [acute glucagon response (AGR)] ( P less than 0.05 ) and the acute *response* ( ASLIR ) ( P less than 0.05 ) . Regulation AGR2 TCAIM 1333448 204402 The inhibition by S-IgA of binding of both S. mutans and free [Ag I/II] to SHA was *dependent* on antibody . Regulation AGT EPHB2 19765632 2183493 Early activation is *involved* in [AGT] upregulation and sustained ERK activation , mediated via AT1 , is responsible for VEGF synthesis . Regulation AGT TNF 9336385 458162 Therefore , the increased mRNA expression may be *involved* in the increased lipopolysaccharide induced expression of [angiotensinogen] gene in fat of SHR at 13 weeks of age . Regulation AGTR2 IL1B 16238458 1589136 Using 50-day-old male rats , we compared the *effects* of on brain gamma-glutamyl transpeptidase ( GGT ; an enzymatic marker of brain capillary endothelium ) [at 2] , 24 and 96 h after either an intravenous ( i.v. ) injection of 5 microg IL-1beta or an intracerebroventricular ( i.c.v. - lateral ventricle ) infusion of 50 ng IL-1beta . Regulation AHCTF1 STK39 18083840 1837662 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation AHR SPHK1 22939756 2734891 S1P and *play* important roles in mast cell dependent , OVA induced allergic inflammation and [AHR] , in part by regulating the NF-?B pathway . Regulation AHR TNF 11751192 889871 gammadelta T cells have been shown to be activated by and to negatively *regulate* [AHR] . Regulation AHR TNF 12502476 1033737 The *effects* of on IL-13 induced [AHR] were also examined . Regulation AHR TNF 12502476 1033738 did not *affect* [AHR] despite marked enhancement of eosinophil infiltration in IL-13 treated mice . Regulation AHR TNF 17336618 1707642 However , studies with TNF-deficient or TNF receptor-deficient mice have not produced a clear picture of the *role* of in the [AHR] associated with allergic inflammation in the mouse . Regulation AHR TNF 17372990 1720546 We have investigated the *role* of in mast cell mediated late [airway hyperresponsiveness (AHR)] using mast cell-deficient WBB6F1-W/W ( v ) ( W/W ( v ) ) mice in a murine model of asthma , which exhibits a biphasic increase in AHR . Regulation AHR TNF 24565903 2924688 IL-1 and *regulation* of [aryl hydrocarbon receptor (AhR)] expression in HSY human salivary cells . Regulation AHSA1 EPHB2 24253595 2910433 The mechanism by which *regulates* JNK and [p38] activity in polyamine depleted IEC-6 cells during apoptosis . Regulation AHSA1 MAP2K6 24253595 2910439 The mechanism by which *regulates* JNK and [p38] activity in polyamine depleted IEC-6 cells during apoptosis . Regulation AHSA1 TNF 23835476 2820891 Mlkl-deficient MEFs and macrophages were indistinguishable from wild-type cells in their ability to activate NF-?B , ERK , JNK , and [p38] in *response* to and lipopolysaccharides (LPS) , respectively . Regulation AKT1 ABCA12 24950409 2947217 In the cell-free assay Li2CO3 significantly inhibited phosphoinositide 3-kinase (PI3K) mediated phosphorylation of [Akt1] at Ser473 , but did not *affect* PI3K mediated PI ( 3,4,5 ) P3 production and 3-phosphoinositide dependent protein kinase 1 ( PDK1 ) -mediated phosphorylation of Akt1 at Thr308 . Regulation AKT1 ANGPT1 20079751 2212523 Similar suppression of *dependent* activation of [Akt] by hyperglycemia was observed in large vessel human endothelial cells . Regulation AKT1 EFNB1 21795402 2476623 EphrinA1-Fc suppressed IGF-I induced activation of Ras and ERK1/2 , but not that of AKT , in C2C12 myoblasts , whereas *affected* neither ERK1/2 nor [AKT] activated by IGF-I . Regulation AKT1 EMP1 23271282 2709678 Western blotting was performed to examine the *effect* of on the [PI3K/AKT] signaling . Regulation AKT1 EPHB2 11306698 804286 These results demonstrated that t-BHQ activated PI3-kinase and [Akt] , which was responsible for ARE mediated rGSTA2 induction , and that might negatively *regulate* rGSTA2 expression , whereas activation of p38 MAP kinase or of JNK by t-BHQ was not associated with the enzyme induction . Regulation AKT1 EPHB2 15976193 1441143 Concurrent with p53 activation , DON activated two anti-apoptotic survival pathways as evidenced by both *dependent* p90 Rsk and [AKT] activation . Regulation AKT1 EPHB2 23880664 2849567 Moreover , kisspeptin stimulated MAPKs and [AKT] signaling , and signaling was functionally *involved* in the kisspeptin induced GnRH expression . Regulation AKT1 FAS 25086185 2956914 Surprisingly , in *response* to suppression , we observed robust increases in both [Akt] and ERK phosphorylation . Regulation AKT1 FBXO32 16870627 1593143 Using dietary restriction , we find that it impedes sarcopenia as well as the effects of aging on [AKT] phosphorylation , FOXO4 phosphorylation , and and MuRF1 transcript *regulation* . Regulation AKT1 FBXO32 17965779 1820374 Our results indicate that does not *affect* the activity of [Akt] itself , but serves as a coactivator for members of the Forkhead family of transcription factors that function downstream of Akt . Regulation AKT1 FOXO1 15256269 1272094 The present data demonstrate that activation of [PKB] is sufficient to mimic the effect of insulin on the expression of G6Pase and that *acts* as an activator of the G6Pase gene indicating that the established cellular models are suitable for the specific analysis of downstream targets of these signaling molecules . Regulation AKT1 FOXO1 16906224 1608395 We show that *regulation* of [Akt] phosphorylation does not require DNA binding and is associated with repression of the pseudokinase tribble 3 (Trb3) , a modulator of Akt activity . Regulation AKT1 FOXO1 17303659 1725984 In contrast , Foxo1-ADA increases p38 activity , and p38 is required for *effects* of on [PKB] , at least in part . Regulation AKT1 FOXO1 18077353 1836809 Repression of Akt-PP2A/B interactions and phosphatase activities contributes , at least in part , to *dependent* increases in [Akt] phosphorylation and kinase activity . Regulation AKT1 FOXO1 19389373 2069975 These findings indicate that [Akt] positively *regulates* the cellular processes of skeletal growth and endochondral ossification , that the Akt-mTOR , , and Akt-GSK3 pathways positively or negatively regulate the cellular processes , and that Akt exerts its function in skeletal development by tuning the three pathways in a manner dependent on the skeletal part . Regulation AKT1 GAB3 18950707 2014534 It has been shown in several model systems that family members may *regulate* both the anti-apoptotic [PI3-K/Akt] and the mitogenic Ras/MAPK pathways , still their role in B-cells have not been investigated in detail . Regulation AKT1 GLP1R 22182839 2537191 Transgene expression restored *dependent* stimulation of cAMP and [Akt] phosphorylation in isolated islets , conferred GLP-1R dependent stimulation of ß cell proliferation , and was sufficient for restoration of GLP-1 stimulated insulin secretion in perifused islets . Regulation AKT1 HBEGF 19470173 2091044 The induced clustering of EGFR was observed minimally after 5 min of integrin crosslinking but was more prominent after 15 min . EGFR clustering had minimal effect on the phosphorylation of [Akt] or Erk1 ,2 in response to EGF in suspended cells or in *response* to in adherent cells . Regulation AKT1 IL1B 11976320 953995 CaMKKc and [Akt] overexpression decreases IRAK1 mediated NF-kappaB activity and its association with MyD88 in *response* to stimulation . Regulation AKT1 IL1B 19685010 2186155 The aim of this study was to compare the *effects* of TNF-alpha , and IFN-gamma on the activation of [protein kinase B (PKB)] , p70 ( S6k ) , mitogen activated protein kinase (MAPK) and p90 ( rsk ) , and on IGF-I stimulated glucose uptake and protein synthesis in mouse C2C12 myotubes . Regulation AKT1 INPP4B 24288008 2926684 We further demonstrate that *regulates* [PI3K/Akt] signaling and exerts a tumor suppressor effect , impacting the proliferative , invasive , and tumorigenic capacity of melanoma cells . Regulation AKT1 MAP2K6 14993781 1216085 Furthermore , using Ad MEK DN , a dominant negative form of MEK , it was found that negatively *regulates* [Akt] phosphorylation upon IGF-1 stimulation . Regulation AKT1 MAP2K6 15172888 1288323 Neither inhibitor *affected* the activation of [Akt] or PKCzeta/lambda , downstream signaling molecules in the PI3K pathway . Regulation AKT1 MAP2K6 16181409 1461939 The importance of these pathways was further confirmed by the activation of both ERK , in a *dependent* manner , and [Akt] , via PI3K . Regulation AKT1 MAP2K6 19446553 2090701 Moreover , pharmacological inhibition of PI3 kinase modulates the intracellular distribution of phospho-ERK1/2 , whereas inhibition *affects* [phospho-Akt] ( Thr308 ) and phospho-Akt ( Ser473 ) . Regulation AKT1 PDE4B 21742807 2500161 Finally , we used primary DLBCL samples to confirm the clinical relevance and biomarker potential of [AKT/mTOR] *regulation* by . Regulation AKT1 PECAM1 15632208 1387987 Sphingosine kinase-1 enhances endothelial cell survival through a *dependent* activation of [PI-3K/Akt] and regulation of Bcl-2 family members . Regulation AKT1 PECAM1 16118242 1454348 *Role* of in the shear-stress induced activation of [Akt] and the endothelial nitric oxide synthase (eNOS) in endothelial cells . Regulation AKT1 PGC 23314346 2742327 Here , we propose a link between hibernation , a well documented response to periods of environmental stress , and reversible insulin resistance , potentially facilitated by key alterations in the [Akt] signaling network , *regulation* , and non coding RNA expression . Regulation AKT1 PLAU 15874933 1405708 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , [Akt] , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Regulation AKT1 S100A7 15994944 1429928 Structural analysis by three-dimensional protein modeling , immunoprecipitation , and yeast two-hybrid assay and functional analysis using transfected reporter gene and Western blot assays revealed that the in vitro *effects* of on [phospho-Akt] and the nuclear factor-kappaB pathway are dependent on the Jab1 binding site and the interaction with Jab1 . Regulation AKT1 S1PR3 12385647 1034892 We previously demonstrated that sphingosine 1-phosphate (S1P) induced PLD activation via the G-protein coupled receptor was *involved* in S1P induced stimulation of PI 3-kinase and [Akt] . Regulation AKT1 S1PR3 20005955 2225099 Dexamethasone protects human fibroblasts from apoptosis via an subtype *dependent* activation of [PKB/Akt] and Bcl XL . Regulation AKT1 SPHK1 15993704 1429717 Inhibition of also did not *affect* EGF stimulated phosphorylation of PI-3 kinase , [Akt] , ERK1/2 or p38 but inhibition of PI-3 kinase with a specific inhibitor LY294002 partly ( 40 % ) inhibited the EGF stimulated increase in SPHK-1 activity . Regulation AKT1 SPHK1 16164409 1456261 Notably , activation of the PI3K downstream mediator [PKB/Akt] by GPCR ligands *involves* the activity of and is independent of EGFR signal transactivation . Regulation AKT1 TGM2 18381937 1892948 *regulates* focal adhesion [kinase/AKT] activation by modulating PTEN expression in pancreatic cancer cells . Regulation AKT1 TLR7 23979601 2850745 Both phosphatidylinositol 3-kinase [(PI3K)-Akt] and p38 mitogen activated protein kinase (MAPK) signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Regulation AKT1 TNF 10669636 665828 Furthermore , we investigated the *effect* of on [Akt] phosphorylation by Western blot analysis with the use of a phosphospecific Akt antibody . Regulation AKT1 TNF 12089369 959657 The *effect* of and MPO-ANCA on [Akt] signaling was studied with immunoprecipitation and glutathione S-transferase pull-down assays . Regulation AKT1 TNF 12089369 959711 p38 MAPK inhibition with 10 microM SB202190 that also decreased ANCA induced superoxide generation prevented S473 phosphorylation of [Akt] in *response* to and to ANCA . Regulation AKT1 TNF 12483539 1024799 In addition , PP1 substantially inhibited the IL-2beta- and *dependent* activation of Erk 1/2 and [Akt] . Regulation AKT1 TNF 12714600 1100554 Phosphorylation of [Akt] and the mammalian target of rapamycin ( but not extracellular regulated kinase or PKCzeta ) in *response* to was inhibited by aspirin treatment . Regulation AKT1 TNF 15026145 1222578 The *effects* of on insulin induced phosphorylation of [protein kinase B-alpha (PKB-alpha)] and downstream enzyme glycogen synthase kinase-3 beta ( GSK-3 beta ) was examined in HepG2 liver cells . Regulation AKT1 TNF 15792609 1386771 *played* a role in induction of [Akt] and MAPK signals in ameloblastoma . Regulation AKT1 TNF 16307448 1502931 In this process , did not *affect* IGF-1 mediated phosphorylation of IRS-1 , IRS-2 , [Akt] , or Erks . Regulation AKT1 TNF 17114809 1677193 Additional studies demonstrated that *effects* on DNA synthesis , ERK , and [Akt] phosphorylation are not mediated through cell surface Gi -coupled S1P receptors , because none of these responses were inhibited by pertussis toxin . Regulation AKT1 TNF 17158207 1694193 Western blot analysis of L6 cell lysates demonstrated impaired insulin stimulated phosphorylation of [Akt] , serine/arginine-rich protein 40 , and glycogen synthase kinase 3beta in *response* to and the short chain C6 ceramide analog . Regulation AKT1 TNF 19836430 2196466 Together , these results suggest that induced oxidative stress *affects* [Akt] activation to regulate actin organization and growth of glioma cells . Regulation AKT1 TNFSF10 21109947 2366206 induced caspase/p38 activation is *responsible* for the increased catalytic and invasive activities of [Akt] . Regulation AKT2 ANGPT1 20079751 2212524 Similar suppression of *dependent* activation of [Akt] by hyperglycemia was observed in large vessel human endothelial cells . Regulation AKT2 EFNB1 21795402 2476624 EphrinA1-Fc suppressed IGF-I induced activation of Ras and ERK1/2 , but not that of AKT , in C2C12 myoblasts , whereas *affected* neither ERK1/2 nor [AKT] activated by IGF-I . Regulation AKT2 EMP1 23271282 2709679 Western blotting was performed to examine the *effect* of on the [PI3K/AKT] signaling . Regulation AKT2 EPHB2 11306698 804287 These results demonstrated that t-BHQ activated PI3-kinase and [Akt] , which was responsible for ARE mediated rGSTA2 induction , and that might negatively *regulate* rGSTA2 expression , whereas activation of p38 MAP kinase or of JNK by t-BHQ was not associated with the enzyme induction . Regulation AKT2 EPHB2 15976193 1441144 Concurrent with p53 activation , DON activated two anti-apoptotic survival pathways as evidenced by both *dependent* p90 Rsk and [AKT] activation . Regulation AKT2 EPHB2 23880664 2849568 Moreover , kisspeptin stimulated MAPKs and [AKT] signaling , and signaling was functionally *involved* in the kisspeptin induced GnRH expression . Regulation AKT2 FAS 25086185 2956915 Surprisingly , in *response* to suppression , we observed robust increases in both [Akt] and ERK phosphorylation . Regulation AKT2 FBXO32 16870627 1593144 Using dietary restriction , we find that it impedes sarcopenia as well as the effects of aging on [AKT] phosphorylation , FOXO4 phosphorylation , and and MuRF1 transcript *regulation* . Regulation AKT2 FBXO32 17965779 1820375 Our results indicate that does not *affect* the activity of [Akt] itself , but serves as a coactivator for members of the Forkhead family of transcription factors that function downstream of Akt . Regulation AKT2 FOXO1 16906224 1608396 We show that *regulation* of [Akt] phosphorylation does not require DNA binding and is associated with repression of the pseudokinase tribble 3 (Trb3) , a modulator of Akt activity . Regulation AKT2 FOXO1 18077353 1836813 Repression of Akt-PP2A/B interactions and phosphatase activities contributes , at least in part , to *dependent* increases in [Akt] phosphorylation and kinase activity . Regulation AKT2 FOXO1 19389373 2069980 These findings indicate that [Akt] positively *regulates* the cellular processes of skeletal growth and endochondral ossification , that the Akt-mTOR , , and Akt-GSK3 pathways positively or negatively regulate the cellular processes , and that Akt exerts its function in skeletal development by tuning the three pathways in a manner dependent on the skeletal part . Regulation AKT2 GAB3 18950707 2014538 It has been shown in several model systems that family members may *regulate* both the anti-apoptotic [PI3-K/Akt] and the mitogenic Ras/MAPK pathways , still their role in B-cells have not been investigated in detail . Regulation AKT2 GLP1R 22182839 2537192 Transgene expression restored *dependent* stimulation of cAMP and [Akt] phosphorylation in isolated islets , conferred GLP-1R dependent stimulation of ß cell proliferation , and was sufficient for restoration of GLP-1 stimulated insulin secretion in perifused islets . Regulation AKT2 HBEGF 19470173 2091046 The induced clustering of EGFR was observed minimally after 5 min of integrin crosslinking but was more prominent after 15 min . EGFR clustering had minimal effect on the phosphorylation of [Akt] or Erk1 ,2 in response to EGF in suspended cells or in *response* to in adherent cells . Regulation AKT2 IL1B 11976320 953996 CaMKKc and [Akt] overexpression decreases IRAK1 mediated NF-kappaB activity and its association with MyD88 in *response* to stimulation . Regulation AKT2 INPP4B 24288008 2926685 We further demonstrate that *regulates* [PI3K/Akt] signaling and exerts a tumor suppressor effect , impacting the proliferative , invasive , and tumorigenic capacity of melanoma cells . Regulation AKT2 MAP2K6 14993781 1216092 Furthermore , using Ad MEK DN , a dominant negative form of MEK , it was found that negatively *regulates* [Akt] phosphorylation upon IGF-1 stimulation . Regulation AKT2 MAP2K6 15172888 1288330 Neither inhibitor *affected* the activation of [Akt] or PKCzeta/lambda , downstream signaling molecules in the PI3K pathway . Regulation AKT2 MAP2K6 16181409 1461946 The importance of these pathways was further confirmed by the activation of both ERK , in a *dependent* manner , and [Akt] , via PI3K . Regulation AKT2 MAP2K6 19446553 2090708 Moreover , pharmacological inhibition of PI3 kinase modulates the intracellular distribution of phospho-ERK1/2 , whereas inhibition *affects* phospho-Akt ( Thr308 ) and [phospho-Akt] ( Ser473 ) . Regulation AKT2 PDE4B 21742807 2500162 Finally , we used primary DLBCL samples to confirm the clinical relevance and biomarker potential of [AKT/mTOR] *regulation* by . Regulation AKT2 PECAM1 15632208 1387988 Sphingosine kinase-1 enhances endothelial cell survival through a *dependent* activation of [PI-3K/Akt] and regulation of Bcl-2 family members . Regulation AKT2 PECAM1 16118242 1454349 *Role* of in the shear-stress induced activation of [Akt] and the endothelial nitric oxide synthase (eNOS) in endothelial cells . Regulation AKT2 PGC 23314346 2742329 Here , we propose a link between hibernation , a well documented response to periods of environmental stress , and reversible insulin resistance , potentially facilitated by key alterations in the [Akt] signaling network , *regulation* , and non coding RNA expression . Regulation AKT2 PLAU 15874933 1405709 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , [Akt] , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Regulation AKT2 S100A7 15994944 1429929 Structural analysis by three-dimensional protein modeling , immunoprecipitation , and yeast two-hybrid assay and functional analysis using transfected reporter gene and Western blot assays revealed that the in vitro *effects* of on [phospho-Akt] and the nuclear factor-kappaB pathway are dependent on the Jab1 binding site and the interaction with Jab1 . Regulation AKT2 S1PR3 12385647 1034900 We previously demonstrated that sphingosine 1-phosphate (S1P) induced PLD activation via the G-protein coupled receptor was *involved* in S1P induced stimulation of PI 3-kinase and [Akt] . Regulation AKT2 S1PR3 20005955 2225100 Dexamethasone protects human fibroblasts from apoptosis via an subtype *dependent* activation of [PKB/Akt] and Bcl XL . Regulation AKT2 SPHK1 15993704 1429718 Inhibition of also did not *affect* EGF stimulated phosphorylation of PI-3 kinase , [Akt] , ERK1/2 or p38 but inhibition of PI-3 kinase with a specific inhibitor LY294002 partly ( 40 % ) inhibited the EGF stimulated increase in SPHK-1 activity . Regulation AKT2 SPHK1 16164409 1456264 Notably , activation of the PI3K downstream mediator [PKB/Akt] by GPCR ligands *involves* the activity of and is independent of EGFR signal transactivation . Regulation AKT2 TGM2 18381937 1892950 *regulates* focal adhesion [kinase/AKT] activation by modulating PTEN expression in pancreatic cancer cells . Regulation AKT2 TLR7 23979601 2850755 Both phosphatidylinositol 3-kinase [(PI3K)-Akt] and p38 mitogen activated protein kinase (MAPK) signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Regulation AKT2 TNF 10669636 665829 Furthermore , we investigated the *effect* of on [Akt] phosphorylation by Western blot analysis with the use of a phosphospecific Akt antibody . Regulation AKT2 TNF 12089369 959659 The *effect* of and MPO-ANCA on [Akt] signaling was studied with immunoprecipitation and glutathione S-transferase pull-down assays . Regulation AKT2 TNF 12089369 959712 p38 MAPK inhibition with 10 microM SB202190 that also decreased ANCA induced superoxide generation prevented S473 phosphorylation of [Akt] in *response* to and to ANCA . Regulation AKT2 TNF 12483539 1024800 In addition , PP1 substantially inhibited the IL-2beta- and *dependent* activation of Erk 1/2 and [Akt] . Regulation AKT2 TNF 12714600 1100555 Phosphorylation of [Akt] and the mammalian target of rapamycin ( but not extracellular regulated kinase or PKCzeta ) in *response* to was inhibited by aspirin treatment . Regulation AKT2 TNF 15792609 1386772 *played* a role in induction of [Akt] and MAPK signals in ameloblastoma . Regulation AKT2 TNF 16307448 1502932 In this process , did not *affect* IGF-1 mediated phosphorylation of IRS-1 , IRS-2 , [Akt] , or Erks . Regulation AKT2 TNF 17114809 1677194 Additional studies demonstrated that *effects* on DNA synthesis , ERK , and [Akt] phosphorylation are not mediated through cell surface Gi -coupled S1P receptors , because none of these responses were inhibited by pertussis toxin . Regulation AKT2 TNF 17158207 1694194 Western blot analysis of L6 cell lysates demonstrated impaired insulin stimulated phosphorylation of [Akt] , serine/arginine-rich protein 40 , and glycogen synthase kinase 3beta in *response* to and the short chain C6 ceramide analog . Regulation AKT2 TNF 19836430 2196467 Together , these results suggest that induced oxidative stress *affects* [Akt] activation to regulate actin organization and growth of glioma cells . Regulation AKT2 TNFSF10 21109947 2366221 induced caspase/p38 activation is *responsible* for the increased catalytic and invasive activities of [Akt] . Regulation AKT3 ANGPT1 20079751 2212525 Similar suppression of *dependent* activation of [Akt] by hyperglycemia was observed in large vessel human endothelial cells . Regulation AKT3 EFNB1 21795402 2476625 EphrinA1-Fc suppressed IGF-I induced activation of Ras and ERK1/2 , but not that of AKT , in C2C12 myoblasts , whereas *affected* neither ERK1/2 nor [AKT] activated by IGF-I . Regulation AKT3 EMP1 23271282 2709680 Western blotting was performed to examine the *effect* of on the [PI3K/AKT] signaling . Regulation AKT3 EPHB2 11306698 804288 These results demonstrated that t-BHQ activated PI3-kinase and [Akt] , which was responsible for ARE mediated rGSTA2 induction , and that might negatively *regulate* rGSTA2 expression , whereas activation of p38 MAP kinase or of JNK by t-BHQ was not associated with the enzyme induction . Regulation AKT3 EPHB2 15976193 1441145 Concurrent with p53 activation , DON activated two anti-apoptotic survival pathways as evidenced by both *dependent* p90 Rsk and [AKT] activation . Regulation AKT3 EPHB2 23880664 2849569 Moreover , kisspeptin stimulated MAPKs and [AKT] signaling , and signaling was functionally *involved* in the kisspeptin induced GnRH expression . Regulation AKT3 FAS 25086185 2956916 Surprisingly , in *response* to suppression , we observed robust increases in both [Akt] and ERK phosphorylation . Regulation AKT3 FBXO32 16870627 1593145 Using dietary restriction , we find that it impedes sarcopenia as well as the effects of aging on [AKT] phosphorylation , FOXO4 phosphorylation , and and MuRF1 transcript *regulation* . Regulation AKT3 FBXO32 17965779 1820376 Our results indicate that does not *affect* the activity of [Akt] itself , but serves as a coactivator for members of the Forkhead family of transcription factors that function downstream of Akt . Regulation AKT3 FOXO1 16906224 1608397 We show that *regulation* of [Akt] phosphorylation does not require DNA binding and is associated with repression of the pseudokinase tribble 3 (Trb3) , a modulator of Akt activity . Regulation AKT3 FOXO1 18077353 1836817 Repression of Akt-PP2A/B interactions and phosphatase activities contributes , at least in part , to *dependent* increases in [Akt] phosphorylation and kinase activity . Regulation AKT3 FOXO1 19389373 2069985 These findings indicate that [Akt] positively *regulates* the cellular processes of skeletal growth and endochondral ossification , that the Akt-mTOR , , and Akt-GSK3 pathways positively or negatively regulate the cellular processes , and that Akt exerts its function in skeletal development by tuning the three pathways in a manner dependent on the skeletal part . Regulation AKT3 GAB3 18950707 2014542 It has been shown in several model systems that family members may *regulate* both the anti-apoptotic [PI3-K/Akt] and the mitogenic Ras/MAPK pathways , still their role in B-cells have not been investigated in detail . Regulation AKT3 GLP1R 22182839 2537193 Transgene expression restored *dependent* stimulation of cAMP and [Akt] phosphorylation in isolated islets , conferred GLP-1R dependent stimulation of ß cell proliferation , and was sufficient for restoration of GLP-1 stimulated insulin secretion in perifused islets . Regulation AKT3 HBEGF 19470173 2091048 The induced clustering of EGFR was observed minimally after 5 min of integrin crosslinking but was more prominent after 15 min . EGFR clustering had minimal effect on the phosphorylation of [Akt] or Erk1 ,2 in response to EGF in suspended cells or in *response* to in adherent cells . Regulation AKT3 IL1B 11976320 953997 CaMKKc and [Akt] overexpression decreases IRAK1 mediated NF-kappaB activity and its association with MyD88 in *response* to stimulation . Regulation AKT3 INPP4B 24288008 2926686 We further demonstrate that *regulates* [PI3K/Akt] signaling and exerts a tumor suppressor effect , impacting the proliferative , invasive , and tumorigenic capacity of melanoma cells . Regulation AKT3 MAP2K6 14993781 1216099 Furthermore , using Ad MEK DN , a dominant negative form of MEK , it was found that negatively *regulates* [Akt] phosphorylation upon IGF-1 stimulation . Regulation AKT3 MAP2K6 15172888 1288337 Neither inhibitor *affected* the activation of [Akt] or PKCzeta/lambda , downstream signaling molecules in the PI3K pathway . Regulation AKT3 MAP2K6 16181409 1461953 The importance of these pathways was further confirmed by the activation of both ERK , in a *dependent* manner , and [Akt] , via PI3K . Regulation AKT3 MAP2K6 19446553 2090715 Moreover , pharmacological inhibition of PI3 kinase modulates the intracellular distribution of phospho-ERK1/2 , whereas inhibition *affects* phospho-Akt ( Thr308 ) and [phospho-Akt] ( Ser473 ) . Regulation AKT3 PDE4B 21742807 2500163 Finally , we used primary DLBCL samples to confirm the clinical relevance and biomarker potential of [AKT/mTOR] *regulation* by . Regulation AKT3 PECAM1 15632208 1387989 Sphingosine kinase-1 enhances endothelial cell survival through a *dependent* activation of [PI-3K/Akt] and regulation of Bcl-2 family members . Regulation AKT3 PECAM1 16118242 1454350 *Role* of in the shear-stress induced activation of [Akt] and the endothelial nitric oxide synthase (eNOS) in endothelial cells . Regulation AKT3 PGC 23314346 2742331 Here , we propose a link between hibernation , a well documented response to periods of environmental stress , and reversible insulin resistance , potentially facilitated by key alterations in the [Akt] signaling network , *regulation* , and non coding RNA expression . Regulation AKT3 PLAU 15874933 1405710 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , [Akt] , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Regulation AKT3 S100A7 15994944 1429930 Structural analysis by three-dimensional protein modeling , immunoprecipitation , and yeast two-hybrid assay and functional analysis using transfected reporter gene and Western blot assays revealed that the in vitro *effects* of on [phospho-Akt] and the nuclear factor-kappaB pathway are dependent on the Jab1 binding site and the interaction with Jab1 . Regulation AKT3 S1PR3 12385647 1034908 We previously demonstrated that sphingosine 1-phosphate (S1P) induced PLD activation via the G-protein coupled receptor was *involved* in S1P induced stimulation of PI 3-kinase and [Akt] . Regulation AKT3 S1PR3 20005955 2225101 Dexamethasone protects human fibroblasts from apoptosis via an subtype *dependent* activation of [PKB/Akt] and Bcl XL . Regulation AKT3 SPHK1 15993704 1429719 Inhibition of also did not *affect* EGF stimulated phosphorylation of PI-3 kinase , [Akt] , ERK1/2 or p38 but inhibition of PI-3 kinase with a specific inhibitor LY294002 partly ( 40 % ) inhibited the EGF stimulated increase in SPHK-1 activity . Regulation AKT3 SPHK1 16164409 1456267 Notably , activation of the PI3K downstream mediator [PKB/Akt] by GPCR ligands *involves* the activity of and is independent of EGFR signal transactivation . Regulation AKT3 TGM2 18381937 1892952 *regulates* focal adhesion [kinase/AKT] activation by modulating PTEN expression in pancreatic cancer cells . Regulation AKT3 TLR7 23979601 2850765 Both phosphatidylinositol 3-kinase [(PI3K)-Akt] and p38 mitogen activated protein kinase (MAPK) signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Regulation AKT3 TNF 10669636 665830 Furthermore , we investigated the *effect* of on [Akt] phosphorylation by Western blot analysis with the use of a phosphospecific Akt antibody . Regulation AKT3 TNF 12089369 959661 The *effect* of and MPO-ANCA on [Akt] signaling was studied with immunoprecipitation and glutathione S-transferase pull-down assays . Regulation AKT3 TNF 12089369 959713 p38 MAPK inhibition with 10 microM SB202190 that also decreased ANCA induced superoxide generation prevented S473 phosphorylation of [Akt] in *response* to and to ANCA . Regulation AKT3 TNF 12483539 1024801 In addition , PP1 substantially inhibited the IL-2beta- and *dependent* activation of Erk 1/2 and [Akt] . Regulation AKT3 TNF 12714600 1100556 Phosphorylation of [Akt] and the mammalian target of rapamycin ( but not extracellular regulated kinase or PKCzeta ) in *response* to was inhibited by aspirin treatment . Regulation AKT3 TNF 15792609 1386773 *played* a role in induction of [Akt] and MAPK signals in ameloblastoma . Regulation AKT3 TNF 16307448 1502933 In this process , did not *affect* IGF-1 mediated phosphorylation of IRS-1 , IRS-2 , [Akt] , or Erks . Regulation AKT3 TNF 17114809 1677195 Additional studies demonstrated that *effects* on DNA synthesis , ERK , and [Akt] phosphorylation are not mediated through cell surface Gi -coupled S1P receptors , because none of these responses were inhibited by pertussis toxin . Regulation AKT3 TNF 17158207 1694195 Western blot analysis of L6 cell lysates demonstrated impaired insulin stimulated phosphorylation of [Akt] , serine/arginine-rich protein 40 , and glycogen synthase kinase 3beta in *response* to and the short chain C6 ceramide analog . Regulation AKT3 TNF 19836430 2196468 Together , these results suggest that induced oxidative stress *affects* [Akt] activation to regulate actin organization and growth of glioma cells . Regulation AKT3 TNFSF10 21109947 2366236 induced caspase/p38 activation is *responsible* for the increased catalytic and invasive activities of [Akt] . Regulation ALAS1 FOXO1 22070747 2548061 These findings support the notion that the complex is *involved* in the control of [ALAS1] expression and suggest further that a vanadate based therapy could be beneficial for the treatment of acute porphyria attacks . Regulation ALAS1 PGC 22070747 2548062 These findings support the notion that the complex is *involved* in the control of [ALAS1] expression and suggest further that a vanadate based therapy could be beneficial for the treatment of acute porphyria attacks . Regulation ALB EDN2 1568295 186941 *Effect* of on plasma volume and [albumin] escape . Regulation ALB GPR132 11122451 758547 Natural killer cell dependent immunoglobulin anti-bovine [serum albumin] ( BSA ) *response* elicited by high molecular weight dextran-BSA conjugates associated with dextran mediated macrophage-natural killer cell interaction . Regulation ALB IL1B 12202007 983015 however , NO did not mediate the *effect* of on [albumin] and fibrinogen production , and played a minor role in IL-1beta mediated urea synthesis suppression . Regulation ALB TF 7077127 20864 In contrast , neither rabbit granule lysozyme nor human induces neutropenia in the rabbit nor does transferrin or bovine [serum albumin] *affect* the adherent properties in vivo of the phagocytic cells of the hamster . Regulation ALB TNF 10203145 606138 The horseradish peroxidase oxidation method was applied for bilirubin-albumin titration studies to test the *effect* of endotoxin and on [bilirubin-albumin] binding . Regulation ALB TNF 11726507 884437 Hepatic cells expressing the non-phosphorylatable C/EBPbeta alanine mutant were refractory to the inhibitory *effects* of on [albumin] transcription since the mutant remained localized to the nucleus . Regulation ALB TNF 1689552 128374 We studied the *effect* of human recombinant ( rTNF alpha ) on transfer of 14C labeled bovine [serum albumin] ( BSA ) across cultured bovine pulmonary arterial endothelial cell monolayers . Regulation ALB TNF 2295699 127549 Since tumor necrosis factor-alpha (TNF alpha) is elevated in cachexia associated diseases , and chronic administration of TNF alpha induces cachexia in animal models , we assessed the *regulation* of [albumin] gene expression by in vivo . Regulation ALB TNF 2461199 100134 Human recombinant only slightly *affects* production of alpha 1-antichymotrypsin and [albumin] in a similar manner as leukocyte cytokines . Regulation ALB TNF 8159107 254317 *Effects* of on glucose and [albumin] production in primary cultures of rat hepatocytes . Regulation ALDH1A1 ZFP57 24080087 2867266 [Aldh1a1] *regulated* transcription factors during B cell differentiation in a sequential manner : 1 ) retinoic acid receptor alpha (Rara) in IgG1 ( + ) /CD19 ( - ) and 2 ) zinc finger protein and peroxisome proliferator activated receptor gamma ( Pparg ) in IgG1 ( + ) /CD19 ( + ) splenocytes . Regulation ALDH2 ADH1B 22703580 2659340 is involved in overproduction of acetaldehyde due to increased ethanol metabolism into acetaldehyde , and [ALDH2*2] is *involved* in accumulation of acetaldehyde due to the deficiency of acetaldehyde metabolism . Regulation ALDH2 PPARA 11505017 847900 We examined the ability of PPAR isoforms to bind to the ALDH2 NRRE in electrophoretic mobility shift assays , their ability to activate the transcription of promoter-reporter constructs containing this NRRE , the *effect* of PPAR ligands on [ALDH2] expression in liver , and the role of the on the expression of ALDH2 by using PPARalpha-null mice . Regulation ALDH2 PRKAA1 21130747 2372870 In this study , we have demonstrated that [ALDH2] acts as a transcriptional repressor in *response* to activation , and MDA modifies ALDH2 and inhibits repressive activity of ALDH2 in general transcription . Regulation ALDH2 PRKAA2 21130747 2372871 In this study , we have demonstrated that [ALDH2] acts as a transcriptional repressor in *response* to activation , and MDA modifies ALDH2 and inhibits repressive activity of ALDH2 in general transcription . Regulation ALDH2 PRKAB1 21130747 2372872 In this study , we have demonstrated that [ALDH2] acts as a transcriptional repressor in *response* to activation , and MDA modifies ALDH2 and inhibits repressive activity of ALDH2 in general transcription . Regulation ALDH2 PRKAB2 21130747 2372873 In this study , we have demonstrated that [ALDH2] acts as a transcriptional repressor in *response* to activation , and MDA modifies ALDH2 and inhibits repressive activity of ALDH2 in general transcription . Regulation ALDH2 PRKAG1 21130747 2372874 In this study , we have demonstrated that [ALDH2] acts as a transcriptional repressor in *response* to activation , and MDA modifies ALDH2 and inhibits repressive activity of ALDH2 in general transcription . Regulation ALDH2 PRKAG2 21130747 2372875 In this study , we have demonstrated that [ALDH2] acts as a transcriptional repressor in *response* to activation , and MDA modifies ALDH2 and inhibits repressive activity of ALDH2 in general transcription . Regulation ALK EPHB2 21415216 2416598 *Role* of and STAT3-survivin signaling pathways in [ALK] inhibitor induced apoptosis in EML4-ALK positive lung cancer . Regulation ALOX5 ALB 9339393 458457 pH-dependent *regulation* of leukocyte [5-lipoxygenase] activity in inflammatory exudates by . Regulation ALOX5 ALOX5AP 10791055 580158 This mechanism can be an universal alternative to the *regulation* of [5-lipoxygenase] activities . Regulation ALOX5 ALOX5AP 1469057 207087 To examine the *role* of in A23187 induced translocation of [5-LO] to a membrane fraction , we have studied the A23187 stimulated translocation of 5-LO in osteosarcoma cells expressing both 5-LO and FLAP , and in osteosarcoma cells expressing 5-LO only . Regulation ALOX5 ALOX5AP 17176247 1701517 Recently two haplotypes ( HapA and HapB ) in the gene encoding ( arachidonate 5-lipoxygenase activating protein ) , the main *regulator* of [5-lipoxygenase] , have been associated with a doubling of the risk of myocardial infarction . Regulation ALOX5 ANXA7 17018618 1630234 Distinct *effects* of and p53 on arachidonate lipoxygenation in prostate cancer cells involve [5-lipoxygenase] transcription . Regulation ALOX5 CA2 12893830 1150174 Recently , we reported that in crude enzyme preparations , a monocyte derived soluble protein (M-DSP) renders [5-lipoxygenase (5-LO)] activity *dependent* . Regulation ALOX5 CA2 16275640 1509376 Importantly , experiments with the 5-LO activating protein inhibitor MK-0591 and the intracellular Ca2+ chelator BAPTA-AM demonstrated that the AA-regulated [5-LO] translocation is FLAP- and *dependent* . Regulation ALOX5 CA2 3134355 94309 Furthermore , although the pellet associated enzyme recovered from ionophore treated leukocytes was inactive , an irreversible , *dependent* membrane association of active [5-lipoxygenase] could be demonstrated in cell-free systems . Regulation ALOX5 CA2 3134355 94311 Together these results are consistent with the hypothesis that ionophore treatment results in a *dependent* translocation of [5-lipoxygenase] from the cytosol to a membrane bound site , that the membrane associated enzyme is preferentially utilized for LT synthesis , and that it is consequently inactivated . Regulation ALOX5 CDC73 1846895 153375 These results indicate that preincubation of peripheral blood neutrophils with GM-CSF enhances the ability of PAF to stimulate leukotriene synthesis by increasing both arachidonic acid availability and [5-lipoxygenase] activation in *response* to . Regulation ALOX5 CDC73 9516893 477376 The priming *effect* of on leukotriene B4 (LTB4) release , [5-lipoxygenase] activity , and intracellular calcium levels in asthmatic neutrophils was examined . Regulation ALOX5 CSF2 8283055 247442 taken together these results indicated a translational *effect* of on the expression of the [5-LO] . Regulation ALOX5 CSF2 8283055 247443 Furthermore GM-CSF did not alter the stability of 5-LO mRNA , in agreement with a posttranscriptional *effect* of on [5-LO] expression in PMNL . Regulation ALOX5 CTR9 1846895 153376 These results indicate that preincubation of peripheral blood neutrophils with GM-CSF enhances the ability of PAF to stimulate leukotriene synthesis by increasing both arachidonic acid availability and [5-lipoxygenase] activation in *response* to . Regulation ALOX5 CTR9 9516893 477377 The priming *effect* of on leukotriene B4 (LTB4) release , [5-lipoxygenase] activity , and intracellular calcium levels in asthmatic neutrophils was examined . Regulation ALOX5 DCP2 23642263 2795764 Recently , we have demonstrated that [5-LO] mRNA expression is *regulated* by alternative splicing and nonsense mediated ( NMD ) . Regulation ALOX5 DUSP13 12893830 1150175 Thus , the inhibitory *effect* of the on [5-LO] could be overcome by the GPx-1 inhibitor mercaptosuccinate and by the broad spectrum GPx inhibitor iodoacetate , as well as by addition of 13 ( S ) -hydroperoxy-9Z,11E-octadecadienoic acid ( 13 ( S ) -HPODE ) . Regulation ALOX5 EPHB2 20554538 2327596 HNE induced [5-LO] expression is *regulated* by and Sp1/p38 MAPK pathways via EGF receptor in murine macrophages . Regulation ALOX5 EXOSC10 23642263 2795767 Recently , we have demonstrated that [5-LO] mRNA expression is *regulated* by alternative splicing and nonsense mediated ( NMD ) . Regulation ALOX5 EXOSC2 23642263 2795760 Recently , we have demonstrated that [5-LO] mRNA expression is *regulated* by alternative splicing and nonsense mediated ( NMD ) . Regulation ALOX5 EXOSC4 23642263 2795762 Recently , we have demonstrated that [5-LO] mRNA expression is *regulated* by alternative splicing and nonsense mediated ( NMD ) . Regulation ALOX5 GPX1 10880344 762381 but not -4 is *involved* in the regulation of cellular [5-lipoxygenase] activity in monocytic cells . Regulation ALOX5 GPX1 2496978 109706 *Involvement* of activity in the stimulation of [5-lipoxygenase] activity by glutathione depleting agents in human polymorphonuclear leukocytes . Regulation ALOX5 GPX2 2496978 109707 *Involvement* of activity in the stimulation of [5-lipoxygenase] activity by glutathione depleting agents in human polymorphonuclear leukocytes . Regulation ALOX5 GPX3 2496978 109708 *Involvement* of activity in the stimulation of [5-lipoxygenase] activity by glutathione depleting agents in human polymorphonuclear leukocytes . Regulation ALOX5 GPX4 2496978 109709 *Involvement* of activity in the stimulation of [5-lipoxygenase] activity by glutathione depleting agents in human polymorphonuclear leukocytes . Regulation ALOX5 GPX5 2496978 109710 *Involvement* of activity in the stimulation of [5-lipoxygenase] activity by glutathione depleting agents in human polymorphonuclear leukocytes . Regulation ALOX5 GPX6 2496978 109711 *Involvement* of activity in the stimulation of [5-lipoxygenase] activity by glutathione depleting agents in human polymorphonuclear leukocytes . Regulation ALOX5 GPX7 2496978 109712 *Involvement* of activity in the stimulation of [5-lipoxygenase] activity by glutathione depleting agents in human polymorphonuclear leukocytes . Regulation ALOX5 GPX8 2496978 109705 *Involvement* of activity in the stimulation of [5-lipoxygenase] activity by glutathione depleting agents in human polymorphonuclear leukocytes . Regulation ALOX5 GRAP2 10779545 691015 At least two *dependent* [5-LO] kinase activities were found . Regulation ALOX5 HDAC1 21883892 2617022 Knockdown of HDAC 1 , 2 and 3 revealed that HDAC2 and HDAC3 but not is *involved* in the up-regulation of [5-LO] mRNA expression . Regulation ALOX5 HDAC2 21883892 2617023 Knockdown of HDAC 1 , 2 and 3 revealed that and HDAC3 but not HDAC1 is *involved* in the up-regulation of [5-LO] mRNA expression . Regulation ALOX5 HDAC3 21883892 2617024 Knockdown of HDAC 1 , 2 and 3 revealed that HDAC2 and but not HDAC1 is *involved* in the up-regulation of [5-LO] mRNA expression . Regulation ALOX5 IL4 11282561 799188 Contrasting *effect* of on the expression of cytosolic phospholipase A2 , [5-lipoxygenase] and 5-lipoxygenase activating protein in peritoneal macrophages from control and ovalbumin sensitized rats . Regulation ALOX5 IL4 11282561 799190 Thus , *acts* differently on cPLA2 , [5-LO] and FLAP expression and AA metabolism in peritoneal macrophages depending on their resident or sensitization induced differentiated status . Regulation ALOX5 JUN 18498541 1917574 We then investigated whether these drugs affect NF-kappaB and activities in A549 lung epithelial cells , and whether this potential regulation *involves* H1-receptor and [5-LO] . Regulation ALOX5 KMT2A 25402609 2960347 We were able to demonstrate that a combined inhibition of HDAC1-3 induces [ALOX5] promoter activity in an *dependent* manner . Regulation ALOX5 LEO1 1846895 153379 These results indicate that preincubation of peripheral blood neutrophils with GM-CSF enhances the ability of PAF to stimulate leukotriene synthesis by increasing both arachidonic acid availability and [5-lipoxygenase] activation in *response* to . Regulation ALOX5 LEO1 9516893 477380 The priming *effect* of on leukotriene B4 (LTB4) release , [5-lipoxygenase] activity , and intracellular calcium levels in asthmatic neutrophils was examined . Regulation ALOX5 LTA 3006030 57279 These findings suggest that a single protein from human leukocytes possesses [5-lipoxygenase] and LTA4 synthase activities and that the synthesis of from 5-HPETE is *controlled* by the same complex multicomponent system that regulates the 5-lipoxygenase reaction . Regulation ALOX5 LTA4H 8203889 261043 However , this effect was not related to inhibition of but rather to a direct or indirect inhibitory *effect* on the enzyme [5-lipoxygenase] in isolated leukocytes . Regulation ALOX5 LTB 1330161 200128 3. The stimulatory *effect* of on [5-LO] activity was further examined with an alternative substrate ; Regulation ALOX5 LTB 20436887 2181466 Synthesis of ( 4 ) is *controlled* by the enzyme [5-lipoxygenase] . Regulation ALOX5 LTB 9142859 428531 The goal of this investigation was to assess the *effect* of on [5-lipoxygenase] activity and to examine the possible mechanisms of this effect . Regulation ALOX5 MAP2K1 11091139 754776 In order to elucidate the *role* of ( MEK-1/2 ) in [5-lipoxygenase (5-LO)] activation we studied the N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -induced 5-LO translocation in human blood neutrophils ( PMNs ) . Regulation ALOX5 MAP2K2 11091139 754777 In order to elucidate the *role* of ( MEK-1/2 ) in [5-lipoxygenase (5-LO)] activation we studied the N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -induced 5-LO translocation in human blood neutrophils ( PMNs ) . Regulation ALOX5 MAP2K3 11091139 754778 In order to elucidate the *role* of ( MEK-1/2 ) in [5-lipoxygenase (5-LO)] activation we studied the N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -induced 5-LO translocation in human blood neutrophils ( PMNs ) . Regulation ALOX5 MAP2K4 11091139 754779 In order to elucidate the *role* of ( MEK-1/2 ) in [5-lipoxygenase (5-LO)] activation we studied the N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -induced 5-LO translocation in human blood neutrophils ( PMNs ) . Regulation ALOX5 MAP2K5 11091139 754780 In order to elucidate the *role* of ( MEK-1/2 ) in [5-lipoxygenase (5-LO)] activation we studied the N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -induced 5-LO translocation in human blood neutrophils ( PMNs ) . Regulation ALOX5 MAP2K6 11091139 754781 In order to elucidate the *role* of ( MEK-1/2 ) in [5-lipoxygenase (5-LO)] activation we studied the N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -induced 5-LO translocation in human blood neutrophils ( PMNs ) . Regulation ALOX5 MAP2K7 11091139 754782 In order to elucidate the *role* of ( MEK-1/2 ) in [5-lipoxygenase (5-LO)] activation we studied the N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -induced 5-LO translocation in human blood neutrophils ( PMNs ) . Regulation ALOX5 MAPK3 16998804 1666302 Hence , in addition to the previously characterised effects on cPLA(2) , critically *regulates* [5-LO] activity in the absence of additional downstream targets in the survival signalling preventing peroxynitrite toxicity . Regulation ALOX5 MAPK3 18164687 1869618 Sequential activation of cytosolic phospholipase A2 (cPLA2) and [5-lipoxygenase (5-LO)] , critically *regulated* by and 2 ( ERK1/2 ) -dependent phosphorylation , mediates U937 cell survival to peroxynitrite . Regulation ALOX5 MET 2989173 48846 Pretreatment of the PMNLs with cytochalasin B strongly potentiated ( up to six-fold ) the stimulatory *effect* of on [5-lipoxygenase] product synthesis , whereas cytochalasin B alone or with arachidonic acid had no significant effect . Regulation ALOX5 MYB 9068066 419003 This paper reports on the *involvement* of in the regulation of [5-lipoxygenase] gene expression during differentiation of human HL-60 cells . Regulation ALOX5 NFKB1 18498541 1917575 We then investigated whether these drugs affect and AP-1 activities in A549 lung epithelial cells , and whether this potential regulation *involves* H1-receptor and [5-LO] . Regulation ALOX5 NFKB1 20554538 2327597 HNE induced [5-LO] expression is *regulated* by and Sp1/p38 MAPK pathways via EGF receptor in murine macrophages . Regulation ALOX5 NOX1 20370567 2266701 In contrast , HNE enhanced [5-LO] activity was not *affected* by inhibition of . Regulation ALOX5 NOX3 20370567 2266702 In contrast , HNE enhanced [5-LO] activity was not *affected* by inhibition of . Regulation ALOX5 NOX4 20370567 2266703 In contrast , HNE enhanced [5-LO] activity was not *affected* by inhibition of . Regulation ALOX5 NOX5 20370567 2266700 In contrast , HNE enhanced [5-LO] activity was not *affected* by inhibition of . Regulation ALOX5 NSD1 19066064 2000164 [ *Effect* of herba on activity of [5-lipoxygenase] in rat thoracic cavity leukocytes ] . Regulation ALOX5 NSD1 19066064 2000165 To investigate the *effect* of herba on the activity of [5-lipoxygenase (5-LO)] , so as to elucidate its mechanisms of anti-inflammatory action which is related to the arachidonic acid ( AA ) metabolism . Regulation ALOX5 PAF1 1846895 153377 These results indicate that preincubation of peripheral blood neutrophils with GM-CSF enhances the ability of PAF to stimulate leukotriene synthesis by increasing both arachidonic acid availability and [5-lipoxygenase] activation in *response* to . Regulation ALOX5 PAF1 9516893 477378 The priming *effect* of on leukotriene B4 (LTB4) release , [5-lipoxygenase] activity , and intracellular calcium levels in asthmatic neutrophils was examined . Regulation ALOX5 PARN 23642263 2795766 Recently , we have demonstrated that [5-LO] mRNA expression is *regulated* by alternative splicing and nonsense mediated ( NMD ) . Regulation ALOX5 PLA2G4A 16998804 1666303 Hence , in addition to the previously characterised effects on , ERK1/2 critically *regulates* [5-LO] activity in the absence of additional downstream targets in the survival signalling preventing peroxynitrite toxicity . Regulation ALOX5 RELA 18498541 1917576 We then investigated whether these drugs affect and AP-1 activities in A549 lung epithelial cells , and whether this potential regulation *involves* H1-receptor and [5-LO] . Regulation ALOX5 RELA 20554538 2327598 HNE induced [5-LO] expression is *regulated* by and Sp1/p38 MAPK pathways via EGF receptor in murine macrophages . Regulation ALOX5 SP1 18179798 1937881 In a previous study , a microsatellite polymorphism in the [5-lipoxygenase] gene promoter *involving* the binding site for the , was associated with carotid intima media thickness ( CIMT ) . Regulation ALOX5 SP1 20554538 2327601 Moreover , the *role* of and NF-?B in HNE induced [5-LO] expression was confirmed by siRNA knockdown of Sp1 and NF-?B . Regulation ALOX5 SP3 17894944 1802740 This is the first report demonstrating that is *involved* in the regulation of [5-LO] promoter activity . Regulation ALOX5 TP53 17018618 1630233 Distinct *effects* of annexin A7 and on arachidonate lipoxygenation in prostate cancer cells involve [5-lipoxygenase] transcription . Regulation ALOX5 UPF1 23642263 2795768 Recently , we have demonstrated that [5-LO] mRNA expression is *regulated* by alternative splicing and nonsense mediated ( NMD ) . Regulation ALOX5 UPF2 23642263 2795761 Recently , we have demonstrated that [5-LO] mRNA expression is *regulated* by alternative splicing and nonsense mediated ( NMD ) . Regulation ALOX5 UPF3B 23642263 2795763 Recently , we have demonstrated that [5-LO] mRNA expression is *regulated* by alternative splicing and nonsense mediated ( NMD ) . Regulation ALOX5 WDR61 1846895 153378 These results indicate that preincubation of peripheral blood neutrophils with GM-CSF enhances the ability of PAF to stimulate leukotriene synthesis by increasing both arachidonic acid availability and [5-lipoxygenase] activation in *response* to . Regulation ALOX5 WDR61 9516893 477379 The priming *effect* of on leukotriene B4 (LTB4) release , [5-lipoxygenase] activity , and intracellular calcium levels in asthmatic neutrophils was examined . Regulation ALOX5 XRN1 23642263 2795765 Recently , we have demonstrated that [5-LO] mRNA expression is *regulated* by alternative splicing and nonsense mediated ( NMD ) . Regulation ALOX5 XRN2 23642263 2795759 Recently , we have demonstrated that [5-LO] mRNA expression is *regulated* by alternative splicing and nonsense mediated ( NMD ) . Regulation ALOX5AP PLAT 17330201 1707350 *Role* of recombinant in free [flap] salvage . Regulation ALX3 HOXB2 11518511 851650 Our results are consistent with a model in which defects in ventral body wall formation require the simultaneous loss of at least and Hoxb4 , and may *involve* [Alx3] and Alx4 . Regulation ALX4 HOXB2 11518511 851652 Our results are consistent with a model in which defects in ventral body wall formation require the simultaneous loss of at least and Hoxb4 , and may *involve* Alx3 and [Alx4] . Regulation AMH IGFBP1 21931746 2479767 Morpholino knockdown of IGFBP-1 rescued the PGC migration defect phenotype in hypoxic embryos , suggesting the *role* of in inducing PGC [mis-migration] . Regulation AMH RNF150 11108557 756968 Non-ovarian tissues failed to produce [MIS] in *response* to . Regulation AMN TNF 8398573 230599 The comparative *effects* of IL-1 and on [AMN-anti-Ly] 2.1 immunoconjugate therapy . Regulation AMOTL1 TNF 23793505 2828618 The *role* of and interferon-? in regulating [angiomotin-like protein 1] expression in lung microvascular endothelial cells . Regulation AMOTL1 TNF 23793505 2828619 Furthermore , we analyzed the *regulation* of [AmotL1] expression by and IFN-? in endothelial cells in vitro . Regulation AMPH CAPN8 17541403 1762516 These results suggest that *dependent* cleavage of [amphiphysin] I inhibits synaptic vesicle endocytosis during neural hyperexcitation and demonstrate a novel post-translational regulation of endocytosis . Regulation ANAPC1 TFPI2 9405394 469806 The direct interaction of PP5 with CDC16 and CDC27 , as well as its overlapping spindle localization in mitosis , suggests that may be *involved* in the regulation of the activity of the [anaphase promoting complex] . Regulation ANAPC2 TFPI2 9405394 469807 The direct interaction of PP5 with CDC16 and CDC27 , as well as its overlapping spindle localization in mitosis , suggests that may be *involved* in the regulation of the activity of the [anaphase promoting complex] . Regulation ANAPC4 TFPI2 9405394 469808 The direct interaction of PP5 with CDC16 and CDC27 , as well as its overlapping spindle localization in mitosis , suggests that may be *involved* in the regulation of the activity of the [anaphase promoting complex] . Regulation ANAPC5 TFPI2 9405394 469801 The direct interaction of PP5 with CDC16 and CDC27 , as well as its overlapping spindle localization in mitosis , suggests that may be *involved* in the regulation of the activity of the [anaphase promoting complex] . Regulation ANAPC7 TFPI2 9405394 469805 The direct interaction of PP5 with CDC16 and CDC27 , as well as its overlapping spindle localization in mitosis , suggests that may be *involved* in the regulation of the activity of the [anaphase promoting complex] . Regulation ANG CTGF 17318787 1664880 We have evaluated the *role* of in vascular and renal damage associated with hypertension and possible interactions with [angiotensin II (Ang II)] . Regulation ANG PLAU 17240317 1690552 This study was designed to determine whether deficiency ( KO ) *affects* carotid artery ligation induced vessel remodeling and the interaction with [angiotensin II (Ang II)] . Regulation ANG RGS2 15292363 1278851 ( RGS-2 ) *plays* a key role in the G protein coupled receptor (GPCR) [angiotensin II (Ang II)] signaling . Regulation ANGPT1 ACE 19578709 2104852 Within the kidneys , Ang- ( 1-7 ) is generated by mediated degradation of Ang II , sequential cleavage of the precursor angiotensin I (Ang I) by ACE2 and ACE , or the *actions* of brush-border membrane peptidases on [Ang I] . Regulation ANGPT1 ACE2 15467007 1359221 ACE2 is expressed in the kidney , but its precise intrarenal localization is unclear , and the *role* of intrarenal in the production of [ANG 1-7] is unknown . Regulation ANGPT1 ACE2 22018415 2513613 in syncytiotrophoblasts could *regulate* release of [Ang 1-7] into the maternal circulation contributing to the vasodilation of the maternal vasculature . Regulation ANGPT1 ANGPT1 15381091 1298594 Functional inhibition of secreted [angiopoietin] : a novel *role* for in coronary vessel patterning . Regulation ANGPT1 ANGPT2 11139469 770072 We tested the *effects* of on [Ang1] , Ang2 , or Tie2 expression in cardiac microvascular endothelial cells expressing the Ang II receptors AT(1) and AT(2) . Regulation ANGPT1 BECN1 22393976 2521080 Modulatory *effects* of on expression of [angiopoietin] and Tie-2 receptor in human cervical cancer cells . Regulation ANGPT1 CBFA2T2 22867989 2666129 The miR-126 *regulates* [angiopoietin-1] signaling and vessel maturation by targeting . Regulation ANGPT1 CPB1 18516587 1965716 The aim was to investigate the *effects* of on plasma levels of the vascular growth factors , [angiopoietin (angpt)-1] , angpt-2 , and vascular endothelial growth factor ( VEGF ) . Regulation ANGPT1 CPB2 18516587 1965717 The aim was to investigate the *effects* of on plasma levels of the vascular growth factors , [angiopoietin (angpt)-1] , angpt-2 , and vascular endothelial growth factor ( VEGF ) . Regulation ANGPT1 CSF2 18782657 2028356 This study assessed the *effect* of perioperative on plasma levels of sVEGFR1 , [Ang-1] and Ang-2 and also the impact of post-GMCSF plasma on in vitro endothelial cell ( EC ) growth and invasion . Regulation ANGPT1 DKK3 23765731 2823909 promotes fibroblast proliferation and myofibroblast differentiation and *regulates* expression of [angiopoietin-1] in prostatic stroma potentially via enhancing PI3K/AKT signaling . Regulation ANGPT1 EPOR 15531367 1332908 Moreover , [Ang-1] expression is *regulated* by under normoxic conditions . Regulation ANGPT1 EPX 15531367 1332909 Moreover , [Ang-1] expression is *regulated* by under normoxic conditions . Regulation ANGPT1 FLT4 20848993 2319272 [Ang-1] induces lymphatic vessel enlargement , sprouting and proliferation in a *dependent* manner . Regulation ANGPT1 GLI1 23378030 2775862 The results of silencing Gli-1 , or NR2F2 , exhibited that exogenous Shh could *regulate* the expressions of VEGF , [Ang-1] , and Ang-2 in astrocytes by activating the NR2F2 , but not the . Regulation ANGPT1 IFNB1 17579115 1763950 Induction of [angiopoietin-1] expression in *response* to was broadly observed in different tumor lines but not in those with defects in IFN signaling . Regulation ANGPT1 IFNG 17466926 1731959 Although stimulation with TNF-alpha or had little or no *effect* on [Ang-1] secretion , costimulation with IFN-gamma plus TNF-alpha dose- and time-dependently diminished secretion of Ang-1 from hOBs . Regulation ANGPT1 IL1B 15126358 1244839 *regulates* [angiopoietin-1] expression in human endothelial cells . Regulation ANGPT1 IL1B 16565972 1549858 As interleukin (IL)-1beta has been found to be an indispensable factor in angiogenic signaling , we further analyzed the *effect* of on the expression of VEGF-A , [Ang-1] , and Ang-2 using a previously established cell culture model . Regulation ANGPT1 IL1B 16565972 1549863 *regulated* VEGF-A and [Ang-1] expressions in a dose dependent manner . Regulation ANGPT1 KLF2 19106103 2036476 Here , we investigated the mechanism of how Ang1/Tie2 signal induces KLF2 expression to clarify the *role* of in [Ang1/Tie2] signal mediated vascular quiescence . Regulation ANGPT1 MAP3K3 17687003 1800441 Taken together , our results suggest that *plays* a critical role in [Ang1/Tie2] signaling to control endothelial cell proliferation and survival and is required for endothelial cells to interact with the myocardium during early embryonic development . Regulation ANGPT1 MAPK1 10585289 571138 In contrast to VEGF mediated biological effects , inhibition of by PD98059 in endothelial cells did not *affect* [angiopoietin-1] mediated survival or migration . Regulation ANGPT1 MAPK10 10585289 571139 In contrast to VEGF mediated biological effects , inhibition of by PD98059 in endothelial cells did not *affect* [angiopoietin-1] mediated survival or migration . Regulation ANGPT1 MAPK11 10585289 571140 In contrast to VEGF mediated biological effects , inhibition of by PD98059 in endothelial cells did not *affect* [angiopoietin-1] mediated survival or migration . Regulation ANGPT1 MAPK12 10585289 571141 In contrast to VEGF mediated biological effects , inhibition of by PD98059 in endothelial cells did not *affect* [angiopoietin-1] mediated survival or migration . Regulation ANGPT1 MAPK13 10585289 571142 In contrast to VEGF mediated biological effects , inhibition of by PD98059 in endothelial cells did not *affect* [angiopoietin-1] mediated survival or migration . Regulation ANGPT1 MAPK14 10585289 571143 In contrast to VEGF mediated biological effects , inhibition of by PD98059 in endothelial cells did not *affect* [angiopoietin-1] mediated survival or migration . Regulation ANGPT1 MAPK15 10585289 571137 In contrast to VEGF mediated biological effects , inhibition of by PD98059 in endothelial cells did not *affect* [angiopoietin-1] mediated survival or migration . Regulation ANGPT1 MAPK3 10585289 571144 In contrast to VEGF mediated biological effects , inhibition of by PD98059 in endothelial cells did not *affect* [angiopoietin-1] mediated survival or migration . Regulation ANGPT1 MAPK4 10585289 571145 In contrast to VEGF mediated biological effects , inhibition of by PD98059 in endothelial cells did not *affect* [angiopoietin-1] mediated survival or migration . Regulation ANGPT1 MAPK6 10585289 571146 In contrast to VEGF mediated biological effects , inhibition of by PD98059 in endothelial cells did not *affect* [angiopoietin-1] mediated survival or migration . Regulation ANGPT1 MAPK7 10585289 571147 In contrast to VEGF mediated biological effects , inhibition of by PD98059 in endothelial cells did not *affect* [angiopoietin-1] mediated survival or migration . Regulation ANGPT1 MAPK8 10585289 571148 In contrast to VEGF mediated biological effects , inhibition of by PD98059 in endothelial cells did not *affect* [angiopoietin-1] mediated survival or migration . Regulation ANGPT1 MAPK9 10585289 571149 In contrast to VEGF mediated biological effects , inhibition of by PD98059 in endothelial cells did not *affect* [angiopoietin-1] mediated survival or migration . Regulation ANGPT1 MTX1 21819747 2462947 The aim of this study was to investigate the *effects* of on levels of VEGF , [Ang-1] , and Ang-2 in organ cultured nasal polyps (NPs) . Regulation ANGPT1 MYLIP 22867989 2666130 The *regulates* [angiopoietin-1] signaling and vessel maturation by targeting p85ß . Regulation ANGPT1 MYLIP 24917145 2946630 [Angiopoietin-1] is *regulated* by and contributes to corneal neovascularization in KLEIP-deficient mice . Regulation ANGPT1 NR2F2 20133706 2213530 We showed that directly *regulates* the transcription of [Angiopoietin-1] in pericytes to enhance neoangiogenesis . Regulation ANGPT1 NR2F2 23378030 2775863 The results of silencing Gli-1 , or NR2F2 , exhibited that exogenous Shh could *regulate* the expressions of VEGF , [Ang-1] , and Ang-2 in astrocytes by activating the , but not the Gli-1 . Regulation ANGPT1 PI3 17215522 1709681 [Angiopoietin] chemotactic activities on neutrophils are *regulated* by activation . Regulation ANGPT1 PTH 17039426 1631028 In this study , we have attempted to characterize the *effects* of ( 1-34 ) on [Ang-1] expression and signaling molecules , employing primary cultured human osteoblast-like cells . Regulation ANGPT1 REN 16585966 1544472 This activity was blocked by the selective renin inhibitor BILA2157 , indicating that was *responsible* for [Ang I] formation . Regulation ANGPT1 S1PR1 18199826 1883762 These effects were independent of extracellular S1P as knockdown or inhibition of , S1P2 , or S1P3 , did not *affect* the [Ang-1] response . Regulation ANGPT1 S1PR2 18199826 1883764 These effects were independent of extracellular S1P as knockdown or inhibition of S1P1 , , or S1P3 , did not *affect* the [Ang-1] response . Regulation ANGPT1 S1PR3 18199826 1883763 These effects were independent of extracellular S1P as knockdown or inhibition of S1P1 , S1P2 , or , did not *affect* the [Ang-1] response . Regulation ANGPT1 SHH 17273793 1691771 inversely *regulates* the expression of [angiopoietin-1] and angiopoietin-2 in fibroblasts . Regulation ANGPT1 SHH 23378030 2775861 The results of silencing Gli-1 , or NR2F2 , exhibited that exogenous could *regulate* the expressions of VEGF , [Ang-1] , and Ang-2 in astrocytes by activating the NR2F2 , but not the Gli-1 . Regulation ANGPT1 TIE1 18848573 2034613 In contrast , [Ang1] inhibition of permeability was not *affected* by suppression of expression . Regulation ANGPT1 TIE1 19543148 2208788 Soluble did not *affect* the association between [Ang-1] or Ang-2 and the PLI ( beta = -0.39 , P < 0.001 ; beta = 0.52 , P < 0.001 , respectively ) , independently of underlying disease . Regulation ANGPT1 TIE1 20227369 2223735 To address the *role* of in [angiopoietin] mediated Tie2 signaling and determine the basis for the behavior of the individual angiopoietins , we used an in vivo FRET based proximity assay to monitor Tie1 and -2 localization and association . Regulation ANGPT1 TIE1 20696992 2306004 Although [Ang-1] binding to human umbilical endothelial cells was partially and integrin *dependent* , Ang-1 binding to monocytes was independent of these factors . Regulation ANGPT1 TNF 14715662 1219536 [Ang-1] expression is up-regulated in *response* to . Regulation ANGPT1 TNF 17466926 1731958 Although stimulation with or IFN-gamma had little or no *effect* on [Ang-1] secretion , costimulation with IFN-gamma plus TNF-alpha dose- and time-dependently diminished secretion of Ang-1 from hOBs . Regulation ANGPT1 VEGFA 11381069 820585 To determine whether ( VEGF ) *regulates* [angiopoietin (Ang)-1] and -2 expression in retinal pigment epithelial (RPE) cells . Regulation ANGPT1 VEGFA 17901375 1824162 These findings demonstrate that *regulates* [angiopoietin-Tie2] signaling by inducing proteolytic cleavage and shedding of Tie2 via a novel PI3K/Akt dependent pathway . Regulation ANGPT1 VEGFA 22235284 2537952 The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by and TNFa and *regulates* [angiopoietin] signalling . Regulation ANGPT1 VEGFA 22577112 2614237 We also analyzed the *effect* of ovarian inhibition on [ANGPT/TIE2] , follicular development , and vascular stability . Regulation ANGPT2 ANGPT1 15381091 1298595 Functional inhibition of secreted [angiopoietin] : a novel *role* for in coronary vessel patterning . Regulation ANGPT2 ANO1 24412532 2917777 We conclude that contributes to CaCC current in human cardiac fibroblasts and that this is *regulated* by [Ang II] acting via the AT1 receptor pathway . Regulation ANGPT2 EDN2 15838360 1352997 The present study demonstrates for the first time the effects of antagonism on the differential expression and *regulation* of [Ang II] receptors in the malignant hypertensive model , SHR-SP , and suggests that the endothelin system may be able to function on the upstream of Ang II signaling . Regulation ANGPT2 EPHB2 10406835 629636 Thus , we show that , through AP-1 activation , is *involved* in [Ang II-induced] TGF-beta(1) mRNA expression in VSMCs and suggest that ERK may participate in vascular remodeling of hypertension . Regulation ANGPT2 EPHB2 11502738 868231 Taken together , these findings demonstrate that [Ang II-induced] cyclin D1 up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a *dependent* manner , and also involves PI3K and SHP-2 . Regulation ANGPT2 EPHB2 15525649 1359908 Inhibition of activation by U0126 or PD98059 significantly decreased EGF dependent COX-2 expression , but did not *affect* [Ang II-dependent] COX-2 expression . Regulation ANGPT2 EPHB2 20926686 2347557 HGF also blocked [Ang II-induced] caspase-3 activation and lactate dehydrogenase release in tissue explants in an *dependent* manner . Regulation ANGPT2 F2R 20180904 2272421 These results suggest a physiologic role for the low concentration of thrombin in maintaining the integrity of the EPCR containing vasculature through the *dependent* inhibition of [Ang2] and P-selectin release from Weibel-Palade bodies . Regulation ANGPT2 FOXO1 16100571 1448310 Whereas [angiopoietin 2 (Ang2)] was exclusively *regulated* by , eNOS , which is essential for postnatal neovascularization , was regulated by Foxo1 and Foxo3a . Regulation ANGPT2 FOXO1 17960565 1844742 Our results support a VEGF dependent induction of Ang-2 in low flow areas , and *dependent* downregulation of [Ang-2] in high flow areas . Regulation ANGPT2 FOXO1 18006475 1851637 As *regulates* the expression of [angiopoietin-2 (Ang-2)] , we determined the role of shear stress and the AMPK in this phenomenon . Regulation ANGPT2 GPR115 17483315 1738955 Kaposi 's sarcoma associated herpesvirus encoded interleukin-6 and *regulate* [angiopoietin-2] expression in lymphatic endothelial cells . Regulation ANGPT2 GPR132 17483315 1738944 Kaposi 's sarcoma associated herpesvirus encoded interleukin-6 and *regulate* [angiopoietin-2] expression in lymphatic endothelial cells . Regulation ANGPT2 GPR87 17483315 1739024 Kaposi 's sarcoma associated herpesvirus encoded interleukin-6 and *regulate* [angiopoietin-2] expression in lymphatic endothelial cells . Regulation ANGPT2 HBEGF 11737589 885870 We studied the *roles* of and endothelial growth factor (EGF) receptor ( EGFR ) in [Ang II-induced] FN expression using mesangial cells . Regulation ANGPT2 HBEGF 11737589 885877 [Ang II-mediated] FN expression was *regulated* by autocrine effects of and TGF-beta , suggesting a novel paradigm for cross-talk between Ang II and growth factor receptor signaling pathways . Regulation ANGPT2 IL1B 16565972 1549859 As interleukin (IL)-1beta has been found to be an indispensable factor in angiogenic signaling , we further analyzed the *effect* of on the expression of VEGF-A , Ang-1 , and [Ang-2] using a previously established cell culture model . Regulation ANGPT2 IL1B 17989112 1850951 For this reason , in cultured mesangial cells ( MC ) , we investigated whether could *regulate* [ANG II-mediated] collagen accumulation and the mechanisms underlying this process . Regulation ANGPT2 MAP2K6 11502738 868238 Taken together , these findings demonstrate that [Ang II-induced] cyclin D1 up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a *dependent* manner , and also involves PI3K and SHP-2 . Regulation ANGPT2 MMP28 17380010 1715329 We next tested the *effect* of broad-spectrum inhibitor ( GM6001 ) on [Ang II-inhibition] of insulin signaling pathway . Regulation ANGPT2 MMP7 17380010 1715344 We next tested the *effect* of broad-spectrum inhibitor ( GM6001 ) on [Ang II-inhibition] of insulin signaling pathway . Regulation ANGPT2 RGS2 15914115 1412598 These results suggest that may be *involved* in short-term regulation of [Ang II-induced] Gi-mediated adenylyl cyclase signalling . Regulation ANGPT2 RGS2 18398336 1893708 This is the first report of silencing *effect* on [Ang II] signaling in a human clinical condition of altered vascular tone regulation and remodeling and establishes RGS-2 as a key regulatory element of Ang II signaling in humans . Regulation ANGPT2 TNF 11305695 803797 We , therefore , examined the *effects* of on [Ang II-induced] increases in PGI2 production in vascular smooth muscle cells ( VSMC ) . Regulation ANGPT2 TNF 15089929 1237837 The *effects* of on the transcription of [Ang-2] were tested in endothelial cells by reverse transcriptase-polymerase chain reaction . Regulation ANGPT2 TNF 19628784 2137869 c-Fms expression in HSCs/promonocytes was mainly regulated by derived from BM CD45 ( - ) CD34 ( - ) stromal cells , and [Ang II] specifically *regulated* the TNF-alpha synthesis and release from BM stromal cells . Regulation ANGPT4 ANGPT1 15381091 1298596 Functional inhibition of secreted [angiopoietin] : a novel *role* for in coronary vessel patterning . Regulation ANGPT4 EGLN3 24067973 2863162 ANDV infection in combination with hypoxic conditions resulted in the enhancement of hypoxia-inducible factor 1a (HIF1a) directed VEGF A , [angiopoietin 4] , and transcriptional *responses* . Regulation ANGPTL3 LIPG 19851103 2196611 Angptl3 concentration is positively correlated with HDL-cholesterol , but not with triglyceride , suggesting that [Angptl3] *regulates* HDL metabolism by inhibiting . Regulation ANGPTL4 EPHB2 20025870 2200260 Our observations suggest that the induction of [ANGPTL4] by PMA in HASM *involves* the activation of PKC , , and JNK pathways . Regulation ANGPTL4 HBEGF 23443317 2781132 We show that *regulates* the expression of VEGFA or [ANGPTL4] via transcriptional regulation of hypoxia-inducible factor-1a and NF-?B . Regulation ANGPTL4 TLR7 22538368 2596020 Here we determined the *effect* of activation on the expression of macrophage [ANGPTL4] . Regulation ANGPTL4 TNF 18081944 1911046 Insulin , leptin , dexamethasone , noradrenaline , and several IL ( IL-1beta , IL-6 , IL-10 , IL-18 ) had little *effect* on [Angptl4/FIAF] mRNA levels in 3T3-L1 adipocytes . Regulation ANK3 TMEM100 12507143 1027273 Painful neuromas : a potential *role* for a structural , [ankyrin G] . Regulation ANK3 TMEM156 12507143 1027291 Painful neuromas : a potential *role* for a structural , [ankyrin G] . Regulation ANK3 TMEM211 12507143 1027371 Painful neuromas : a potential *role* for a structural , [ankyrin G] . Regulation ANK3 TMEM213 12507143 1027308 Painful neuromas : a potential *role* for a structural , [ankyrin G] . Regulation ANKRD1 AKT1 22085644 2540850 Treatment of reHASMCs with Akt , IKKa , I?Ba , or NF-?B inhibitor inhibits the loss of desmin induced Ankrd1 up-regulation , suggesting mediated [Ankrd1] *regulation* . Regulation ANKRD1 AKT2 22085644 2540851 Treatment of reHASMCs with Akt , IKKa , I?Ba , or NF-?B inhibitor inhibits the loss of desmin induced Ankrd1 up-regulation , suggesting mediated [Ankrd1] *regulation* . Regulation ANKRD1 AKT3 22085644 2540852 Treatment of reHASMCs with Akt , IKKa , I?Ba , or NF-?B inhibitor inhibits the loss of desmin induced Ankrd1 up-regulation , suggesting mediated [Ankrd1] *regulation* . Regulation ANKRD1 PSMA1 22892129 2666290 <26S proteasome> *regulation* of [Ankrd1/CARP] in adult rat ventricular myocytes and human microvascular endothelial cells . Regulation ANKRD1 PSMA2 22892129 2666291 <26S proteasome> *regulation* of [Ankrd1/CARP] in adult rat ventricular myocytes and human microvascular endothelial cells . Regulation ANKRD1 PSMA3 22892129 2666292 <26S proteasome> *regulation* of [Ankrd1/CARP] in adult rat ventricular myocytes and human microvascular endothelial cells . Regulation ANKRD1 PSMA4 22892129 2666293 <26S proteasome> *regulation* of [Ankrd1/CARP] in adult rat ventricular myocytes and human microvascular endothelial cells . Regulation ANKRD1 PSMA5 22892129 2666294 <26S proteasome> *regulation* of [Ankrd1/CARP] in adult rat ventricular myocytes and human microvascular endothelial cells . Regulation ANKRD1 PSMA6 22892129 2666295 <26S proteasome> *regulation* of [Ankrd1/CARP] in adult rat ventricular myocytes and human microvascular endothelial cells . Regulation ANKRD1 PSMA7 22892129 2666296 <26S proteasome> *regulation* of [Ankrd1/CARP] in adult rat ventricular myocytes and human microvascular endothelial cells . Regulation ANKRD1 PSMB1 22892129 2666297 <26S proteasome> *regulation* of [Ankrd1/CARP] in adult rat ventricular myocytes and human microvascular endothelial cells . Regulation ANKRD1 PSMB2 22892129 2666298 <26S proteasome> *regulation* of [Ankrd1/CARP] in adult rat ventricular myocytes and human microvascular endothelial cells . Regulation ANKRD1 PSMB3 22892129 2666299 <26S proteasome> *regulation* of [Ankrd1/CARP] in adult rat ventricular myocytes and human microvascular endothelial cells . Regulation ANKRD1 PSMB4 22892129 2666300 <26S proteasome> *regulation* of [Ankrd1/CARP] in adult rat ventricular myocytes and human microvascular endothelial cells . Regulation ANKRD1 PSMB5 22892129 2666301 <26S proteasome> *regulation* of [Ankrd1/CARP] in adult rat ventricular myocytes and human microvascular endothelial cells . Regulation ANKRD1 PSMB6 22892129 2666302 <26S proteasome> *regulation* of [Ankrd1/CARP] in adult rat ventricular myocytes and human microvascular endothelial cells . Regulation ANKRD1 PSMB7 22892129 2666303 <26S proteasome> *regulation* of [Ankrd1/CARP] in adult rat ventricular myocytes and human microvascular endothelial cells . Regulation ANKRD1 PSMC1 22892129 2666304 <26S proteasome> *regulation* of [Ankrd1/CARP] in adult rat ventricular myocytes and human microvascular endothelial cells . Regulation ANKRD1 PSMC2 22892129 2666305 <26S proteasome> *regulation* of [Ankrd1/CARP] in adult rat ventricular myocytes and human microvascular endothelial cells . Regulation ANKRD1 PSMC3 22892129 2666306 <26S proteasome> *regulation* of [Ankrd1/CARP] in adult rat ventricular myocytes and human microvascular endothelial cells . Regulation ANKRD1 PSMC4 22892129 2666307 <26S proteasome> *regulation* of [Ankrd1/CARP] in adult rat ventricular myocytes and human microvascular endothelial cells . Regulation ANKRD1 PSMC5 22892129 2666308 <26S proteasome> *regulation* of [Ankrd1/CARP] in adult rat ventricular myocytes and human microvascular endothelial cells . Regulation ANKRD1 PSMC6 22892129 2666309 <26S proteasome> *regulation* of [Ankrd1/CARP] in adult rat ventricular myocytes and human microvascular endothelial cells . Regulation ANKRD1 PSMD13 22892129 2666310 <26S proteasome> *regulation* of [Ankrd1/CARP] in adult rat ventricular myocytes and human microvascular endothelial cells . Regulation ANKRD1 PSMD4 22892129 2666311 <26S proteasome> *regulation* of [Ankrd1/CARP] in adult rat ventricular myocytes and human microvascular endothelial cells . Regulation ANO1 ANGPT2 24412532 2917776 We conclude that [ANO1] contributes to CaCC current in human cardiac fibroblasts and that this is *regulated* by acting via the AT1 receptor pathway . Regulation ANO1 CA2 22394518 2577245 These studies provide new perspectives on *regulation* of [Ano1] by . Regulation ANO1 CA2 23462688 2749887 This means that *dependent* activation of KCa3.1 and [TMEM16A] protects the cells against early hemolysis . Regulation ANO1 CA2 24692353 2931506 [TMEM16A] is directly *regulated* by cytosolic as well as indirectly by its interaction with calmodulin . Regulation ANO1 CALM3 24692353 2931507 [TMEM16A] is directly *regulated* by cytosolic Ca2+ as well as indirectly by its interaction with . Regulation ANO1 CFTR 22178883 2518396 Recent findings showing that TMEM16A forms the essential part of CaCC , prompted us to examine whether *controls* [TMEM16A] . Regulation ANPEP TNF 11089884 580918 and TGF-beta , however , had an *effect* neither on mRNA expression nor on the enzyme activity of [APN] in both cell lines . Regulation ANXA6 EPHB2 10212283 607894 and 3 ) *dependent* eIF4E phosphorylation but not PI3-kinase dependent [p70] ( S6k ) activation correlates with PGF2alpha induced global protein synthesis and bFGF-2 expression in VSMC . Regulation ANXA6 EPHB2 16824602 1666063 A specific inhibitor , U0126 , as well as PI3K inhibitors , differentially *regulated* IL-10 and IL-12 [p70] productions . Regulation ANXA6 EPHB2 20511709 2270505 Both LPS and GA stimulated the production of IL-6 , IL-10 , [IL12p70] and TNFalpha in a p38- and/or *dependent* manner . Regulation ANXA6 IL1B 16499573 1528911 When infected HeLa cells were co-cultured with THP-1 cells , IL-6 and IL-8 secretion was sustained , expression followed a bell shaped curve and IL-10 , [IL-12p70] and TNF-alpha synthesis was down *regulated* . Regulation ANXA6 IL1B 19685010 2186157 The aim of this study was to compare the *effects* of TNF-alpha , and IFN-gamma on the activation of protein kinase B (PKB) , [p70] ( S6k ) , mitogen activated protein kinase (MAPK) and p90 ( rsk ) , and on IGF-I stimulated glucose uptake and protein synthesis in mouse C2C12 myotubes . Regulation ANXA6 SPHK1 21435724 2416928 To investigate the immune modulatory *role* of as opposed to SphK2 specifically for the Th1 propagating [IL-12p70] we compared WT and SphK1 ( -/- ) splenocytes and Flt3-ligand differentiated BMCs of WT and SphK1 ( -/- ) , representing dendritic cells as major producers of IL-12p70 , incubated with LPS . Regulation ANXA6 SPHK1 21435724 2416940 To further characterize *dependent* [IL-12p70] regulation we exogenously applied S1P , SEW2871 and the new potent S1P1 agonist CYM5442 . Regulation ANXA6 TLR7 16009271 1431461 However , [IL-12p70] production in *response* to stimulating agents plus IFN-gamma was consistently lower in AIMV medium although also under serumfree culture conditions , nanogram quantities of IL-12 were produced . Regulation ANXA6 TLR7 19917677 2166690 In *response* to most ligands , neonatal innate immune cells , including monocytes and conventional and plasmacytoid dendritic cells produced less [IL-12p70] and IFN-alpha ( and consequently induced less IFN-gamma ) , moderately less TNF-alpha , but as much or even more IL-1beta , IL-6 , IL-23 , and IL-10 than adult cells . Regulation ANXA6 TP63 8906830 394390 Pretreatment of IFN-gamma 0/0 mice with recombinant mouse IFN-gamma ( rIFN-gamma ) enhanced circulating TNF-alpha by as much as sixfold , but serum IL-12 and IL-12 [p70] *responses* increased by only twofold or less . Regulation AOC3 TNF 12604697 1062709 *Regulation* of [semicarbazide-sensitive amine oxidase] expression by in adipocytes : functional consequences on glucose transport . Regulation AOC3 TNF 12604697 1062710 In this study , the murine 3T3-L1 preadipose cell line was used to investigate [SSAO] *regulation* by , a cytokine that is synthesized in fat cells and known to be involved in obesity linked insulin resistance . Regulation AP5M1 TNFSF10 23665015 2791275 We found that [MUDENG] is rapidly processed in *response* to in Jurkat and BJAB cells with time line similar to that of caspase activation . Regulation APAF1 FAS 17603723 1765193 Our results show an in-vivo linkage between , p53 and [Apaf-1] transcription *regulation* . Regulation APBB1 RASD1 18922798 1994421 interacts with FE65 to *regulate* [FE65-amyloid] precursor protein dependent transcription . Regulation APC AXIN2 15355978 1334090 We also show an unexpected *role* for in facilitating the ubiquitination-proteasome mediated down-regulation of [APC] through the oligomerization of Axin . Regulation APC AXIN2 15355978 1334092 Our results suggest a new mechanism for the *regulation* of [APC] by and Wnt signaling . Regulation APC ID1 18372912 1938170 The negative *effect* of on [APC] ( Cdh1 ) results in suppression of APC ( Cdh1 ) -induced Aurora A and Cdc20 degradation , leading to failure in cytokinesis . Regulation APC ITGAL 15210787 1262070 The beta ( 2 ) integrin is *involved* in T [cell-APC] interactions , but the roles of CD11b , CD11c , and CD11d in such interactions have not been examined . Regulation APC ITGAL 1971292 132810 Similarly , anti-LFA-1 mAb inhibited the response of T cells to Ag presented by the wild-type A20 to a much greater degree than by the mutant cells , indicating that is *involved* in interaction of T cells with the former , but not latter , [APC] . Regulation APC TLR7 19228816 2061887 This report addresses the potential contribution of dendritic cells ( DC ) to changes in adaptive immune function after injury by specifically measuring injury induced changes in splenic DC numbers and subsets , cell-surface markers , *responses* , and [APC] function . Regulation APC TLR7 24374810 2906653 Therapeutic effects of DZ2002 , a reversible SAHH inhibitor , on lupus-prone NZB×NZW F1 mice via interference with mediated [APC] *response* . Regulation APC TNF 9053444 417227 A [APC] are *independent* of , IL-4 , IL-10 , IL-12p40 , IFN-gamma , IL-13 , TGF-beta , and PGE2 . Regulation APCS CD14 22974465 2673868 Lastly , we discuss the observation that negatively *regulates* alternative activation of [APCs] during helminth infection . Regulation APCS TLR7 16439962 1534179 To model for the *effects* of activation on the UV effect on [antigen-APCs] , XS52 cell line was used to study this interaction in an in vitro model system . Regulation APLN EPHB2 24770651 2937031 The AngII inhibition mediated beneficial effects are likely attributable , at least in part , to restoration of *dependent* [apelin/APJ] expression in diet induced obesity related hypertension . Regulation APLN STK39 24311379 2899323 Taken together , our data present compelling evidence suggesting that [Apelin] signaling *regulates* lymphatic development by promoting Akt/protein kinase B activity in a VEGF-C/VEGF receptor 3-independent manner during zebrafish embryogenesis . Regulation APLN TNF 16723381 1575922 [Apelin] *regulation* by was further studied in cultured explants of human adipose tissue . Regulation APOA1 GLP1R 21239158 2504645 These data indicate that [chylomicron] formation is essential and activation of the is *involved* in activation of the nutritional anti-inflammatory pathway by lipid enriched nutrition . Regulation APOA1 RARB 9392425 467755 iv ) RLR alpha and/or and RXR alpha are *involved* in the activation of [apoA-I] expression by retinoids . Regulation APOA1 TNF 16475830 1524158 To determine the molecular mechanisms responsible for the *effect* of on the [apoAI] promoter activity , HepG2 cells were exposed to both genetic and pharmacological modulators of TNF alpha mediated signaling in the presence or absence of TNF alpha . Regulation APOA1 TNF 22271762 2586216 these results elucidate the cell type-specific mechanism of the mediated *regulation* of [apoA-I] gene expression in monocytes and macrophages . Regulation APOA1 TNF 7948424 277278 or IL-1 did not *affect* hepatic apo E or [apo A-I] mRNA levels while a combination of TNF + IL-1 decreased both mRNA levels by 50 % . Regulation APOA2 GLP1R 21239158 2504646 These data indicate that [chylomicron] formation is essential and activation of the is *involved* in activation of the nutritional anti-inflammatory pathway by lipid enriched nutrition . Regulation APOA2 NR2F1 1639815 194727 The finding that HNF-4 , ARP-1 , EAR-2 and can *regulate* the expression of the apoB , apoCIII , and [apoAII] genes suggest that these nuclear hormone receptors may be an important part of the signal transduction pathways modulating lipid metabolism and cholesterol homeostasis . Regulation APOA4 GLP1R 21239158 2504647 These data indicate that [chylomicron] formation is essential and activation of the is *involved* in activation of the nutritional anti-inflammatory pathway by lipid enriched nutrition . Regulation APOB CD14 23880187 2821417 Cell-free experiments performed in CD14 coated microtiter wells confirmed that was *involved* in [LDL] ( - ) binding . Regulation APOB FAS 9409230 471443 The *effects* of marine omega-3 polyunsaturated and antioxidants on the oxidative modification of [LDL] were studied in a randomized , double-blind , placebo controlled trial . Regulation APOB LBP 15784577 1386072 The presence of LPS on HDL further enhanced *dependent* interactions of [LDL] with HDL and increased the stability of the HDL-LDL complexes . Regulation APOB LIPG 12164779 997645 To investigate the *effects* of on binding and uptake of high-density [lipoprotein] ( HDL ) , as well as on the selective uptake of HDL derived cholesterol esters (CEs) , HepG2 cells were infected with adenovirus coding for EDL . Regulation APOB LIPG 12909635 1150880 *Effects* of nonlipolytic ligand function of on high density [lipoprotein] metabolism in vivo . Regulation APOB LIPG 22972429 2706278 *regulates* plasma high-density [lipoprotein-cholesterol] ( HDL-C ) levels by promoting HDL catabolism . Regulation APOB PCSK9 15741654 1403108 Wild-type inhibits LDL clearance but does not *affect* apoB containing [lipoprotein] production in mouse and cultured cells . Regulation APOB PCSK9 15772090 1389929 Evidence for *effect* of mutant on [apolipoprotein B] secretion as the cause of unusually severe dominant hypercholesterolaemia . Regulation APOB PCSK9 17493938 1766638 Although *controls* [low density lipoprotein (LDL)] receptor ( LDLR ) levels post-transcriptionally , several questions concerning its mode of action remain unanswered . Regulation APOB PCSK9 19601924 2162582 downregulates the low-density lipoprotein receptor (LDLR) in the liver by binding to the epidermalgrowth factor-like repeat A ( EGF-A ) domain of the LDLR and thereby *controls* the level of [LDL-c] in plasma . Regulation APOB PCSK9 20172854 2236497 Consequently , the *role* of in modulating circulating [LDL] makes it a promising therapeutic target for treating hypercholesterolemia and coronary heart disease . Regulation APOB PCSK9 22426206 2577567 *Regulation* of hepatic [LDL] receptors by mTORC1 and in mice . Regulation APOB PCSK9 23115612 2695874 The *role* of in the regulation of circulating low density [lipoprotein-cholesterol] ( LDL-c ) levels is ascribed to binding of circulating PCSK9 to the LDL receptor (LDLR) and subsequent lysosomal degradation of LDLR . Regulation APOB PCSK9 24278757 2714859 It also describes the epidemiological and experimental evidences of the regulatory *effect* of on [LDL] cholesterol levels and cardiovascular diseases and summarizes the different pharmacological approaches under development for inhibiting PCSK9 expression , processing , and the interaction with LDLR . Regulation APOB PCSK9 24308640 2904848 In the present study , we have investigated the role of circulating ( pro-protein convertase subtilisin kexin type 9 ) , an important *regulator* of [LDL] ( low-density lipoprotein) receptor expression , in the development of this hyperlipidaemic phenotype . Regulation APOB TNF 10480607 643529 These purified human islet MVEC ( HI-MVEC ) express von Willebrand factor , take up high levels of acetylated [LDL] , and upregulate endothelial cell leukocyte adhesion molecule 1 in *response* to . Regulation APOB TNF 11735091 885662 Anthropometric measurements , fasting plasma glucose , insulin , [lipoprotein] concentrations , glucose , and insulin *responses* to OGTT , , and leptin concentrations were similar between the genotype at the -308 site both in hypertensive and normotensive groups . Regulation APOB TNF 16411405 1494782 They highly proliferated and were expanded in long-term culture without alterations of their phenotypic and functional properties ( [Dil-ac-LDL] uptake , wound repair , capillary-like network formation , and *response* ) . Regulation APOB TNF 2244888 145858 We have investigated the *effects* of recombinant human on the cellular binding of human [low density lipoprotein (LDL)] to human skin fibroblasts . Regulation APOB TNF 8307154 249075 The *effect* of on the oxidative modification of [LDL] by U937 human monocytes or murine endothelial cells was studied by determination of the lipid peroxidation product content and the electrophoretic mobility of the particle . Regulation APOB TNF 8387950 218081 Preincubation of the cells with cycloheximide or actinomycin D totally abolished the up-regulatory *effect* of on low-density [lipoprotein] receptors . Regulation APOB TNF 9578494 503262 We show that lipopolysaccharide-free actetylated [low-density lipoprotein (LDL)] , but not native LDL , stimulates secretion by rat peritoneal macrophages and the signal-transduction pathways *involved* . Regulation APOB TNF 9633941 513213 Dominant negative *effect* of TGF-beta1 and on basal and IL-6 induced [lipoprotein(a)] and apolipoprotein(a) mRNA expression in primary monkey hepatocyte cultures . Regulation APOBEC2 IL1B 16427049 1515827 We demonstrate that [APOBEC2] expression is strongly enhanced in *response* to both tumour necrosis factor-alpha (TNF-alpha) and . Regulation APOBEC2 TNF 16427049 1515826 We demonstrate that [APOBEC2] expression is strongly enhanced in *response* to both and interleukin-1beta . Regulation APOC2 GLP1R 21239158 2504648 These data indicate that [chylomicron] formation is essential and activation of the is *involved* in activation of the nutritional anti-inflammatory pathway by lipid enriched nutrition . Regulation APOC3 GLP1R 21239158 2504649 These data indicate that [chylomicron] formation is essential and activation of the is *involved* in activation of the nutritional anti-inflammatory pathway by lipid enriched nutrition . Regulation APOC3 NR2F1 1639815 194731 The finding that HNF-4 , ARP-1 , EAR-2 and can *regulate* the expression of the apoB , [apoCIII] , and apoAII genes suggest that these nuclear hormone receptors may be an important part of the signal transduction pathways modulating lipid metabolism and cholesterol homeostasis . Regulation APOC3 TNF 9350999 460914 By competition and supershift experiments , we demonstrate that TNFalpha induced complexes were related to C/EBPdelta/NF-IL6beta and p50 and that overexpression of C/EBPdelta was able to reproduce the inhibitory *effect* of on the [apoC-III] promoter . Regulation APOD RARB 8943263 399743 By contrast , , RARgamma- , and RXR-selective retinoids did not *affect* [apoD] gene expression . Regulation APOE GLP1R 21239158 2504650 These data indicate that [chylomicron] formation is essential and activation of the is *involved* in activation of the nutritional anti-inflammatory pathway by lipid enriched nutrition . Regulation APOE TNF 1709937 158078 Human recombinant , a potent inhibitor of LPL gene transcription , had no *effect* on adipocyte [apoE] mRNA levels . Regulation APOM TNF 11944906 929922 *Effects* of platelet activating factor , , and interleukin-1alpha on the expression of [apolipoprotein M] in HepG2 cells . Regulation APP IL1B 12542857 1029287 In vitro data indicate that expression of [APP] may be *regulated* in part by the inflammatory cytokine . Regulation APP IL1B 17549252 1752484 A beneficial *role* for in [Alzheimer disease] ? Regulation APP IL1B 18262272 1884933 In PHH , several [APP] like CRP , haptoglobin (HP) , lipopolysaccharide binding protein (LBP) or hepcidin ( HAMP ) were *regulated* similarly by and IL-6 , though signal transduction pathways of these cytokines are different . Regulation APP IL1B 19668572 2119445 We have studied the *effects* of and S100B on the expression and processing of [APP] using a retinal-vitreal model . Regulation APP IL1B 20395292 2267300 In addition , miR-101 contributed to the regulation of [APP] in *response* to the proinflammatory cytokine ( IL-lbeta ) . Regulation APP NGFR 9495541 476638 The neurotrophic activity of [APP] was *independent* of the TrkA because neither phospholipase C-gamma1 nor TrkA exhibited tyrosine phosphorylations with APP treatment . Regulation APP S100B 19668572 2119444 We have studied the *effects* of IL-1beta and on the expression and processing of [APP] using a retinal-vitreal model . Regulation APP SORL1 17220890 1689169 These data suggest that inherited or acquired changes in expression or function are mechanistically *involved* in causing [Alzheimer disease] . Regulation AQP1 EPHB2 12600999 1079455 These data demonstrate that the activation of , p38 kinase , and JNK pathways and the hypertonicity response element in the AQP1 promoter are *involved* in hypertonicity induced [AQP1] expression in mIMCD-3 cells . Regulation AQP1 TNF 22456279 2594959 Allogenic BMSC transplantation can protect against ALI in a rat SAP model and can also *regulate* the expression levels of [AQP-1] and -5 by inhibiting IL-1ß and . Regulation AQP3 TNF 19619514 2118175 In addition , inhibitors of p38 and extracellular signal regulated kinase ( ERK ) abolished the *effect* of on [AQP3] expression level , whereas inhibitors for NF-kappaB did not . Regulation AQP3 TNF 22531364 2793357 [AQP3] expression is downregulated in *response* to ( TNF- a ) . Regulation AQP4 IL1B 16987239 1617786 We tested the hypothesis that [AQP4] is induced in *response* to . Regulation AQP4 IL1B 16987239 1617788 The *effects* of on induction of [AQP4] were concentration and time dependent . Regulation AQP4 IL1B 16987239 1617789 The *effects* of on [AQP4] were mediated through IL-1beta receptors because they were abolished by co-incubation with IL-1 receptor antagonist . Regulation AQP5 EPHB2 20360133 2273343 In summary , the capsaicin induced secretory mechanism involved activation of TRPV1 and upregulation of [AQP5] in an *dependent* manner and promoted the redistribution of AQP5 in submandibular gland cells . Regulation AQP5 TNF 11279049 819480 Inhibition of nuclear factor kappaB (NF-kappaB) translocation to the nucleus blocks the *effect* of on [AQP5] expression , indicating that activation of NF-kappaB is required , whereas inhibition of extracellular signal regulated or p38 mitogen activated protein kinases showed no effect . Regulation AQP5 TNF 22456279 2594961 Allogenic BMSC transplantation can protect against ALI in a rat SAP model and can also *regulate* the expression levels of [AQP-1 and -5] by inhibiting IL-1ß and . Regulation AR ANKRD1 23811403 2820749 This investigation explored the effects of testosterone on Ankrd1 and Ankrd2 expression and determined whether or Ankrd2 binds to or *regulates* the transcriptional activity of the [androgen receptor (AR)] . Regulation AR CCND1 16461912 1522756 In the prostate , acts through discrete mechanisms to negatively *regulate* [androgen receptor (AR)] activity and thus limit androgen dependent proliferation . Regulation AR EPHB2 19946123 2190649 *regulates* calpain 2-induced [androgen receptor] proteolysis in CWR22 relapsed prostate tumor cell lines . Regulation AR FOXA1 18178153 1856276 ( HNF-3alpha ) negatively *regulates* [androgen receptor] transactivation in prostate cancer cells . Regulation AR FOXA1 21915096 2491963 Dual *role* of in [androgen receptor] binding to chromatin , androgen signalling and prostate cancer . Regulation AR SPHK1 23113536 2740602 Therefore , we investigated the *effect* of inhibitors on [androgen receptor] expression . Regulation AR TNF 10953159 724413 To see the *effect* of on [androgen receptor (AR)] , western blotting and northern blotting were performed after extraction of total protein and total RNA from LNCaP cells . Regulation AR TNF 17968653 1826626 FSH-sensitive murine sertoli cell lines immortalized by human telomerase gene hTERT express the [androgen receptor] in *response* to stimulation . Regulation ARC EPHB2 21559295 2429483 Convulsant doses of a dopamine D1 receptor agonist result in *dependent* increases in Zif268 and [Arc/Arg3.1] expression in mouse dentate gyrus . Regulation ARCN1 EPHB2 19428337 2077022 These data suggest that signaling *plays* an important role in acute lung injury and pharmacologic inhibition of ERK provides a promising new therapeutic strategy for lung inflammatory diseases and in particular [COPD] . Regulation ARF1 EPHB2 21660463 2489865 Totally , the functional *roles* of and p21 for [ARF] in p53 independent tumor suppression were demonstrated . Regulation ARF1 TNF 16467041 1523430 These findings suggest that the *role* of in [ARF] may be in linkage disequilibrium with some other severity genes not yet genetically determined . Regulation ARF1 ZFP57 20808772 2314176 Our findings implicate in the transcriptional *regulation* of the [Ink4a/Arf] locus and suggest that the interaction of Zfp277 with Bmi1 is essential for the recruitment of PRC1 to the Ink4a/Arf locus . Regulation ARF3 EPHB2 21660463 2489867 Totally , the functional *roles* of and p21 for [ARF] in p53 independent tumor suppression were demonstrated . Regulation ARF3 TNF 16467041 1523431 These findings suggest that the *role* of in [ARF] may be in linkage disequilibrium with some other severity genes not yet genetically determined . Regulation ARF3 ZFP57 20808772 2314194 Our findings implicate in the transcriptional *regulation* of the [Ink4a/Arf] locus and suggest that the interaction of Zfp277 with Bmi1 is essential for the recruitment of PRC1 to the Ink4a/Arf locus . Regulation ARF4 EPHB2 21660463 2489869 Totally , the functional *roles* of and p21 for [ARF] in p53 independent tumor suppression were demonstrated . Regulation ARF4 TNF 16467041 1523432 These findings suggest that the *role* of in [ARF] may be in linkage disequilibrium with some other severity genes not yet genetically determined . Regulation ARF4 ZFP57 20808772 2314212 Our findings implicate in the transcriptional *regulation* of the [Ink4a/Arf] locus and suggest that the interaction of Zfp277 with Bmi1 is essential for the recruitment of PRC1 to the Ink4a/Arf locus . Regulation ARF5 EPHB2 21660463 2489871 Totally , the functional *roles* of and p21 for [ARF] in p53 independent tumor suppression were demonstrated . Regulation ARF5 TNF 16467041 1523433 These findings suggest that the *role* of in [ARF] may be in linkage disequilibrium with some other severity genes not yet genetically determined . Regulation ARF5 ZFP57 20808772 2314230 Our findings implicate in the transcriptional *regulation* of the [Ink4a/Arf] locus and suggest that the interaction of Zfp277 with Bmi1 is essential for the recruitment of PRC1 to the Ink4a/Arf locus . Regulation ARF6 EPHB2 21660463 2489873 Totally , the functional *roles* of and p21 for [ARF] in p53 independent tumor suppression were demonstrated . Regulation ARF6 SLC28A1 22869721 2666132 Consistent with negative *regulation* of [ARF-6] by RAB-10 and , we found overaccumulation of endosomal phosphatidylinositol-4,5-bisphosphate [ PI ( 4,5 ) P2 ] in cnt-1 and rab-10 mutants and reduced endosomal PI ( 4,5 ) P2 levels in arf-6 mutants . Regulation ARF6 TNF 16467041 1523434 These findings suggest that the *role* of in [ARF] may be in linkage disequilibrium with some other severity genes not yet genetically determined . Regulation ARF6 ZFP57 20808772 2314248 Our findings implicate in the transcriptional *regulation* of the [Ink4a/Arf] locus and suggest that the interaction of Zfp277 with Bmi1 is essential for the recruitment of PRC1 to the Ink4a/Arf locus . Regulation ARG1 EPHB2 21559295 2429484 Convulsant doses of a dopamine D1 receptor agonist result in *dependent* increases in Zif268 and [Arc/Arg3.1] expression in mouse dentate gyrus . Regulation ARG2 EPHB2 21559295 2429485 Convulsant doses of a dopamine D1 receptor agonist result in *dependent* increases in Zif268 and [Arc/Arg3.1] expression in mouse dentate gyrus . Regulation ARG2 STK39 18621907 1966376 Together , the data demonstrate a central *role* of in the upregulation of both [arginase II] and iNOS in bPAEC in response to L/T treatment . Regulation ARHGAP35 EPHB2 20439493 2268331 We identify [p190A RhoGAP] as a major *target* for signaling in adhesion assembly and identify roles for ERK phosphorylation of the C terminus in p190A localization and activity . Regulation ARHGEF25 RGS2 24299002 2899069 Dynamics of [Gaq-protein-p63RhoGEF] interaction and its *regulation* by . Regulation ARHGEF25 RGS2 24299002 2899071 Analysis of the *effect* of ( regulator of G-protein signalling 2 ) on the dynamics of Gaq activity and their interaction with [p63RhoGEF] showed that RGS2 is able to accelerate both deactivation of Gaq proteins and dissociation of Gaq and p63RhoGEF to a similar extent . Regulation ARHGEF7 NES 21383062 2420874 These studies show that p110ß NLS and p85ß *regulate* [p85ß/p110ß] nuclear localization , supporting the idea that nuclear , but not cytoplasmic , p110ß controls cell survival . Regulation ARID1B EPHB2 12824291 1113649 These results indicate that *dependent* [R-Smad] linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells . Regulation ARRB1 EPHB2 19153083 2060970 A cell-permeable , 25-mer N-stearoylated betaarrestin1 peptide that encompassed the N-domain MEK1 binding site blocked betaarrestin1/MEK1 association in HEK cells and recapitulated the altered phenotype seen with the D26A/D29A-betaarrestin1 in compromising the *dependent* phosphorylation of [betaarrestin1] . Regulation ARSA ACP1 6131046 25033 In cartilage , the activity of was significantly elevated in animals on low dietary levels of ascorbate ( p less than 0.01 ) , but [arylsulfatase A] and arylsulfatase B activities were not *affected* by varying the dietary intake of ascorbate . Regulation ARSA ACP2 6131046 25034 In cartilage , the activity of was significantly elevated in animals on low dietary levels of ascorbate ( p less than 0.01 ) , but [arylsulfatase A] and arylsulfatase B activities were not *affected* by varying the dietary intake of ascorbate . Regulation ARSA ACP5 6131046 25035 In cartilage , the activity of was significantly elevated in animals on low dietary levels of ascorbate ( p less than 0.01 ) , but [arylsulfatase A] and arylsulfatase B activities were not *affected* by varying the dietary intake of ascorbate . Regulation ARSA ACP6 6131046 25036 In cartilage , the activity of was significantly elevated in animals on low dietary levels of ascorbate ( p less than 0.01 ) , but [arylsulfatase A] and arylsulfatase B activities were not *affected* by varying the dietary intake of ascorbate . Regulation ARSA CDC73 11064108 746856 The increases in plasma PAF correlated well with the ASA associated decreases in body temperature , suggesting that *plays* an important role in [ASA] in W/W ( v ) mice . Regulation ARSA CLN6 15010453 1243381 Defective endoplasmic reticulum-resident membrane *affects* lysosomal degradation of endocytosed [arylsulfatase A] . Regulation ARSA COPS5 23424245 2760021 In addition , the csn5b mutant showed higher tolerance to salt , indicating that *regulation* of [AsA] synthesis affects the response to salt stress . Regulation ARSA COPS5 23424245 2760024 Together , our data reveal a regulatory *role* of in light-dark regulation of [AsA] synthesis . Regulation ARSA CPOX 24204637 2864603 However , the variable clinical response to [5-ASA] and frequent deterioration in *response* to inhibitors , has prompted an in depth simultaneous evaluation of multiple lipid mediators ( including eicosanoids ) within the inflammatory milieu in UC . Regulation ARSA CTR9 11064108 746857 The increases in plasma PAF correlated well with the ASA associated decreases in body temperature , suggesting that *plays* an important role in [ASA] in W/W ( v ) mice . Regulation ARSA LEO1 11064108 746860 The increases in plasma PAF correlated well with the ASA associated decreases in body temperature , suggesting that *plays* an important role in [ASA] in W/W ( v ) mice . Regulation ARSA MADCAM1 11472325 841441 [5-ASA] , sulfasalazine and 6-MP , while beneficial in inflammatory bowel disease , do not directly *control* , and are beneficial through inhibition of other inflammatory processes . Regulation ARSA MPI 18755683 1975329 Moreover , a reduction of PMI1 expression through RNA interference resulted in a substantial decrease in the total AsA content of leaves of knockdown PMI1 plants , whereas the complete inhibition of expression did not *affect* the total [AsA] levels in leaves of knock-out PMI2 plants . Regulation ARSA MPI 18755683 1975330 Consequently , this study improves our understanding of the molecular and functional properties of Arabidopsis PMI isoenzymes and provides genetic evidence of the *involvement* of , but not PMI2 , in the biosynthesis of [AsA] in Arabidopsis plants . Regulation ARSA OXA1L 3580009 73814 In a separate , more direct , ultracentrifugation assay , unbound [ASA] levels were similarly *affected* by and the other ligands . Regulation ARSA PAF1 11064108 746858 The increases in plasma PAF correlated well with the ASA associated decreases in body temperature , suggesting that *plays* an important role in [ASA] in W/W ( v ) mice . Regulation ARSA PMM1 17217471 1689153 Collectively , this study improves our understanding on the molecular and functional properties of plant PMM and provides genetic evidence on the *involvement* of in the biosynthesis of [AsA] in Arabidopsis and N. benthamiana plants . Regulation ARSA PMM2 17217471 1689154 Collectively , this study improves our understanding on the molecular and functional properties of plant PMM and provides genetic evidence on the *involvement* of in the biosynthesis of [AsA] in Arabidopsis and N. benthamiana plants . Regulation ARSA WDR61 11064108 746859 The increases in plasma PAF correlated well with the ASA associated decreases in body temperature , suggesting that *plays* an important role in [ASA] in W/W ( v ) mice . Regulation ARSD LBP 7681085 214216 Studies with human CD14 expressing transfectants of the murine B cell line 70Z/3 also revealed *dependent* cross linking of [125I-ASD-LPS] to CD14 . Regulation ARSE TNFSF10 16581346 1543709 As disruption of mitochondrial transmembrane potential ( DeltaPsim ) , Leu-Glu-His-Asp [ase] ( IETD ase ) activity , and the appearance of hypodiploid DNA + cells were markedly suppressed in IFN-gamma treated FLS in *response* to , IFN-gamma induced suppression was supposed to achieve at upstream of caspase-8 . Regulation ART1 IL1B 16720358 1565300 *Effects* of on [RT1-A/RT1-DM] at the maternal-fetal interface during pregnancy in rats . Regulation ASIC3 EPHB2 17696763 1829732 Expression of [acid sensing ion channel 3 (ASIC3)] in nucleus pulposus cells of the intervertebral disc is *regulated* by p75NTR and signaling . Regulation ASMT TNF 17014691 1629411 Here we analyzed the *effect* of and corticosterone on the transcription of the Aa-nat , [hiomt] and 14-3-3 protein genes in denervated pineal glands of rats stimulated for 5 hr with norepinephrine , using real-time reverse transcription-polymerase chain reaction . Regulation ASS1 IL1B 16380201 1581699 Biphasic *effect* of on the activity of [argininosuccinate synthetase] in Caco-2 cells . Regulation ASS1 IL1B 16380201 1581700 Conversely , blocking the action of NO by antioxidant agents , the stimulatory *effect* of on [ASS] activity was restored , as measured at 24 h . Regulation ASS1 TNF 17354225 1727240 Aberrant *regulation* of [argininosuccinate synthetase] by in human epithelial ovarian cancer . Regulation ATF1 EPHB2 17082637 1643388 Our findings collectively indicate that signaling *plays* key roles in both Elk1 , CREB , and [ATF-1] activation and the subsequent recruitment of c-Jun to the FRA-1 promoter in response to TNF-alpha in pulmonary epithelial cells . Regulation ATF1 TNF 17082637 1643387 Our findings collectively indicate that ERK signaling plays key roles in both Elk1 , CREB , and [ATF-1] activation and the subsequent recruitment of c-Jun to the FRA-1 promoter in *response* to in pulmonary epithelial cells . Regulation ATF2 EPHB2 23591579 2789602 Taken together , these data indicated that the increasing of ATF2 expression is mediated via oxidative stress induced by arsenic in SV-HUC-1 cells , and JNK or p38 rather than is *responsible* for arsenic induced [ATF2] expression . Regulation ATF2 MAP2K6 16050133 1438535 In contrast , the inhibitor , PD98059 , or the JNK inhibitor , SP600125 , had no significant *effect* on DNA binding of [ATF-2] . Regulation ATF3 EPHB2 14723708 1197941 Furthermore , the ERK pathway inhibits the TNFalpha mediated induction of ATF3 mRNA , but not its stability , suggesting the *involvement* of activity in the transcriptional regulation of the [ATF3] gene . Regulation ATF4 EGLN3 19922526 2240918 Taken together , *regulated* stabilization of [ATF-4] by hindering oxygen dependent degradation may play a critical role in linking cell fate decisions to oxygen availability . Regulation ATF4 EGLN3 21951999 2502560 These results suggest that PHD1 and *control* the transactivation activity of [ATF4] . Regulation ATF4 TLR7 23241898 2724555 In this report , we found that [ATF4] is also involved in the mediated innate immune *response* , which participates in TLR4 signal transduction and mediates the secretion of a variety of cytokines . Regulation ATF6 DAPK1 22874566 2710063 IFNG stimulated proteolytic cleavage of [ATF6] , and MAPK1/3 ( ERK2/1 ) -dependent phosphorylation of CEBPB together *control* the expression of . Regulation ATP2A2 TNF 21263314 2431154 The *effect* of and interleukin-6 on [SERCA2] gene expression and diastolic calcium decay of HL-1 cardiomyocytes were investigated . Regulation ATP5J TNF 15158150 1250636 We investigated the *role* of in the generation and release of [CF6] . Regulation ATP5O ARSA 12842867 1149723 Gill [Na+-K+-ATPase] activity was not *affected* by . Regulation ATP5O CABP4 10569182 567971 Expression of regucalcin and microsomal [Ca2+-ATPase] *regulation* in rat brain : attenuation with increasing age . Regulation ATP5O CABP4 10569182 567981 The expression of regucalcin and its *effect* on the microsomal [Ca2+-ATPase] activity in rat brain tissues was investigated . Regulation ATP5O CAPN8 17497432 1739778 *Regulation* of plasma membrane [Ca2+-ATPase] in human platelets by . Regulation ATP5O EDN2 1662089 172727 The *effects* of on fluid and bicarbonate absorption and Na+/K+ [ATPase] activity in the proximal straight tubule were investigated . Regulation ATP5O EDN2 2549995 117486 Therefore , we examined the *effects* of on [Na-K-ATPase] in an enzyme preparation from hog cerebral cortex . Regulation ATP5O EPHB2 16973240 1647004 We conclude that leptin induced stimulation of renal Na ( + ) , K ( + ) [-ATPase] *involves* H ( 2 ) O ( 2 ) generation , Src kinase , transactivation of the EGF receptor , and stimulation of . Regulation ATP5O IL1B 12433284 1015678 The *effect* of on urine flow rates and Na ( + ) /K ( + ) [-ATPase] activity and expression was studied in rat intestinal and renal epithelia . Regulation ATP5O IL1B 12957788 1137949 Curcumin , a JNK/AP-1 inhibitor , partially abolished the *effect* of on [ATPase] expression but did not interfere with the effect of PGE2 . Regulation ATP5O IL1B 14985981 1236662 The signal transduction pathway that mediates the *effect* of on the [Na+-K+-ATPase] in LLC-PK1 cells . Regulation ATP5O IL1B 9825769 549211 Studies on the *effect* of on the activity of the intestinal Na+-K+ [ATPase] demonstrated a significant inhibition of the pump . Regulation ATP5O PGC 21687978 2455573 Na , [K-ATPase] activity in mouse muscle is *regulated* by AMPK and . Regulation ATP5O TGM2 8354524 227432 The Ca ( 2+ ) -activable , however , did not *play* any role in the activation of the ( Ca ( 2+ ) -Mg2+ ) [-ATPase] . Regulation ATP5O TMEM100 21220422 2408753 [Na/K-ATPase] ( NKA ) activity is dynamically *regulated* by an inhibitory interaction with a small , phospholemman (PLM) . Regulation ATP5O TMEM100 7918987 272661 The [Ca-ATPase] in the cardiac sarcoplasmic reticulum membrane is *regulated* by an amphipathic , phospholamban . Regulation ATP5O TMEM156 21220422 2408771 [Na/K-ATPase] ( NKA ) activity is dynamically *regulated* by an inhibitory interaction with a small , phospholemman (PLM) . Regulation ATP5O TMEM156 7918987 272679 The [Ca-ATPase] in the cardiac sarcoplasmic reticulum membrane is *regulated* by an amphipathic , phospholamban . Regulation ATP5O TMEM211 21220422 2408851 [Na/K-ATPase] ( NKA ) activity is dynamically *regulated* by an inhibitory interaction with a small , phospholemman (PLM) . Regulation ATP5O TMEM211 7918987 272759 The [Ca-ATPase] in the cardiac sarcoplasmic reticulum membrane is *regulated* by an amphipathic , phospholamban . Regulation ATP5O TMEM213 21220422 2408788 [Na/K-ATPase] ( NKA ) activity is dynamically *regulated* by an inhibitory interaction with a small , phospholemman (PLM) . Regulation ATP5O TMEM213 7918987 272696 The [Ca-ATPase] in the cardiac sarcoplasmic reticulum membrane is *regulated* by an amphipathic , phospholamban . Regulation ATP5O TNF 17028035 1654288 Because the Na ( + ) -K ( + ) ATPase is a key player in the contraction of cardiomyocytes , this work was undertaken to study the *effect* of on the Na ( + ) -K ( + ) [ATPase] in rat heart . Regulation ATP5O TNF 17499749 1739941 The *effect* of on liver Na ( + ) -K ( + ) [ATPase] was studied in Sprague-Dawley rats and in HepG2 cells . Regulation ATP5O TNF 18348163 1925286 Since TNF-alpha is known to be a pro and anti-apoptotic cytokine , this work was undertaken to study the *effect* of on the Na ( + ) /K ( + ) [ATPase] in HepG2 cells and to determine the signaling pathway involved . Regulation ATP5O TNF 20222869 2254375 The aim of this work was to investigate the *effect* of on the [ATPase] , and consequently its implication in kidney malfunction , using LLC-PK1 cells . Regulation ATP5O TNF 9142647 428528 The following experiments quantitate the *effects* of TSH , aging , , and TGF-beta 1 on the expression and activity of Na+/K ( + ) [-ATPase] activity in FRTL-5 cells . Regulation ATP7A CLU 22130675 2542335 and COMMD1 independently *regulate* degradation of the mammalian copper ATPases [ATP7A] and ATP7B . Regulation ATP7A RARB 19127267 2019616 Taken together , our data demonstrates [ATP7A] expression is *regulated* by and it has effects on intracellular copper levels , revealing a link between the anticancer action of retinoids and copper metabolism . Regulation ATRX F2R 18842153 1981895 We now report that the SNF2-type chromatin remodeling protein [ATRX] *controls* the expression of eutherian ancestral genes that have translocated to autosomes in the mouse . Regulation ATXN1 S100B 20477910 2288583 Taken together our data support a mechanism where PKA dependent mutant [ataxin-1] phosphorylation and aggregation can be *regulated* by signaling . Regulation AURKA NEDD9 23539442 2782555 Here , we show that , a known activator of AURKA , is directly *involved* in [AURKA] stability . Regulation AVP IL1B 7817387 285350 These results suggest that *affects* the release of [AVP] and ACTH , blood pressure and thermogenesis via prostaglandins (PGs) , but ANH release related to IL-1 beta may not be mediated by PGs . Regulation AVP IL1B 7931009 275173 An investigation of the *effects* of on plasma [arginine vasopressin] in the rat : role of adrenal steroids . Regulation AVP IL1B 7931009 275174 did not *affect* plasma [AVP] in sham operated control animals over the 4 h period of study . Regulation AVP IL1B 8396869 230343 Indomethacin abolished the [AVP] and ACTH *responses* to , but potentiated the pressor and hypothermic responses and increased plasma ANP . Regulation AVP IL1B 8413817 233933 In contrast however , while hypothalamic tissue from adrenalectomized rats , unlike that from intact animals , responded to IL-6 ( 5-20 ng/ml ) with a pronounced hypersecretion of AVP , the [AVP] *responses* to IL-1 alpha and were largely unaffected by adrenalectomy as too were those to IL-8 . Regulation AVP IL1B 9266547 408000 induced *effects* on plasma oxytocin and [arginine vasopressin] : role of adrenal steroids and route of administration . Regulation AVP TNF 8159270 254324 Neither nor interferon-gamma had any *effect* on the basal or acetylcholine induced [AVP] release from the hypothalamus . Regulation AVPR2 RGS2 17475820 1744140 This study provides evidence that [V2R] signaling is negatively *regulated* by ( RGS2 ) , a member of the family of RGS proteins . Regulation AVPR2 RGS2 17475820 1744142 It is proposed that is *involved* in negative feedback regulation of [V2R] signaling . Regulation AXIN1 MAP2K6 22895053 2682799 Taken together , these findings indicate that NRAS-mutant melanoma share with BRAF-mutant melanoma the potential to regulate apoptosis upon inhibition through WNT3A and dynamic *regulation* of cellular [AXIN1] . Regulation AXIN2 APC 16798748 1579132 binds beta-catenin and is *involved* in the [Axin] complex , suggesting that APC regulates beta-catenin phosphorylation . Regulation AXIN2 CDK2 15063782 1230954 *regulates* the interaction of [Axin] with beta-catenin . Regulation AXIN2 CDK5 21940452 2487657 Together , our findings reveal a new regulatory mechanism of axon formation through *dependent* phosphorylation of [Axin] . Regulation AXIN2 CDK5 23972596 2832862 The nuclear localization of Axin and hence the switch of IPs from proliferative to differentiative status are strictly controlled by the *dependent* phosphorylation of [Axin] at Thr485 . Regulation AXIN2 CDX2 23393221 2787033 *Regulation* of APC and [AXIN2] expression by intestinal tumor suppressor in colon cancer cells . Regulation AXIN2 CDX2 23393221 2787048 The aim was to investigate the *role* of decreased level on the expression of APC , [AXIN2] and GSK3ß in migrating colon cancer cells at the invasive front . Regulation AXIN2 CTBP1 12711682 1083402 HMG box transcription factor TCF-4 's interaction with *controls* the expression of the Wnt target [Axin2/Conductin] in human embryonic kidney cells . Regulation AXIN2 CTNNB1 12636920 1068530 [Axin2] , a negative regulator of the Wnt pathway , is directly *controlled* by and shows oscillating expression in the PSM , even when Notch signaling is impaired , alternating with Lfng expression . Regulation AXIN2 GSK3B 10944533 744115 Axam inhibited the complex formation of Dvl with Axin and the activity of Dvl to suppress *dependent* phosphorylation of [Axin] . Regulation AXIN2 HDAC1 23110995 2710711 X-radiation and siRNA inhibit expression of HDAC1 and HDAC2 , weaken the inhibitory *effect* of on [Axin] , upregulate Axin expression and induce apoptosis of lung cancer cells . Regulation AXIN2 HDAC2 23110995 2710712 X-radiation and siRNA inhibit expression of HDAC1 and HDAC2 , weaken the inhibitory *effect* of on [Axin] , upregulate Axin expression and induce apoptosis of lung cancer cells . Regulation AXIN2 HIC1 12192039 980788 Interestingly , HIC differs from I-mfa in that I-mfa affects both Axin function and T-cell factor- or LEF regulated transcription in the Wnt signaling pathway while *affects* primarily [Axin] function . Regulation AXIN2 HIC2 12192039 980787 Interestingly , HIC differs from I-mfa in that I-mfa affects both Axin function and T-cell factor- or LEF regulated transcription in the Wnt signaling pathway while *affects* primarily [Axin] function . Regulation AXIN2 LRP6 17202189 1680720 Wnt11/beta-catenin signaling in both oocytes and early embryos acts through mediated *regulation* of [axin] . Regulation AXIN2 LRP6 17202189 1680728 In the full-grown oocyte , before maturation , we find that [axin] levels are also *regulated* by Wnt11 and . Regulation AXIN2 LRP6 17202189 1680738 In the oocyte , Wnt11 and/or *regulates* [axin] to maintain beta-catenin at a low level , while in the embryo , asymmetrical Wnt11/LRP6 signaling stabilizes beta-catenin and enriches it on the dorsal side . Regulation AXIN2 NKD1 19888210 2161377 We show that Ube2m interacts with and modulates beta-catenin stability , and that the antagonistic *effect* of on Wnt signaling requires interaction with [Axin] , itself a negative pathway regulator . Regulation AXIN2 PRMT1 21242974 2425517 Consistent with the *role* of in the regulation of [Axin] , knockdown of PRMT1 enhanced the level of cytoplasmic ß-catenin as well as ß-catenin dependent transcription activity . Regulation AXIN2 RBBP4 23110995 2710713 X-radiation and siRNA inhibit expression of HDAC1 and HDAC2 , weaken the inhibitory *effect* of on [Axin] , upregulate Axin expression and induce apoptosis of lung cancer cells . Regulation AXIN2 RBBP7 23110995 2710714 X-radiation and siRNA inhibit expression of HDAC1 and HDAC2 , weaken the inhibitory *effect* of on [Axin] , upregulate Axin expression and induce apoptosis of lung cancer cells . Regulation AXIN2 RNF146 21799911 2461994 Ubiquitin ligase *regulates* tankyrase and [Axin] to promote Wnt signaling . Regulation AXIN2 ROR2 19720827 2152256 To determine whether Ror2 can inhibit canonical Wnt signaling in vivo , we examined the *effect* of loss on the expression of the Wnt reporter [Axin2] ( LacZ ) , finding increased reporter activity in Ror2 null mice , demonstrating that Ror2 can also inhibit Wnt/beta-catenin signaling in the context of intact tissues . Regulation AXIN2 RUNX2 15262978 1290174 In the present study , we have investigated whether could *play* a regulatory role in [Axin-] and Dvl mediated JNK activation . Regulation AXIN2 SMURF2 20858899 2342927 The protein stability of [Axin] , a negative regulator of Wnt signaling , is *regulated* by ( Smurf2 ) . Regulation AXIN2 TP53 18372914 1938173 Therefore , we postulated that alteration of the degradation complex [AXIN2] ( axis inhibition protein 2 ) and betaTrCP ( beta-transducin repeat containing protein ) and *regulation* could result in beta-catenin protein accumulation in lung cancer . Regulation AXIN2 USP34 21383061 2420870 The ubiquitin-specific protease *regulates* [axin] stability and Wnt/ß-catenin signaling . Regulation AXIN2 USP34 21383061 2420872 Our results indicate that functions downstream of the ß-catenin destruction complex to *control* the stability of [axin] and opposes its tankyrase dependent ubiquitination . Regulation AXIN2 WNT1 10906131 743680 In L cells where APC is intact , Axin ( delta ) ( beta)(-catenin ) inhibited *dependent* accumulation of beta-catenin but not [Axin-] ( 298-832 ) ( delta ) ( beta)(-catenin ) in which the APC- and beta-catenin binding sites are deleted . Regulation AXIN2 WNT1 11809809 906824 signaling is *controlled* by the negative regulator [conductin/axin2/axil] , which induces degradation of beta-catenin by functional interaction with the tumor suppressor APC and the serine/threonine kinase GSK3beta . Regulation AXIN2 WNT1 12636920 1068523 [Axin2] , a negative regulator of the Wnt pathway , is directly *controlled* by and shows oscillating expression in the PSM , even when Notch signaling is impaired , alternating with Lfng expression . Regulation AXIN2 WNT1 16303557 1485443 Finally , we demonstrate an association of Galpha ( o ) with Fz that is also very rapidly ( t1/2 < 1 min ) perturbed upon Wnt-3a stimulation and that the *dependent* effects on both [GSK3beta/Axin2] and Galpha ( o ) /Fz are pertussis-toxin sensitive . Regulation AXIN2 WNT1 16303557 1485488 We conclude that rapid disruption of [GSK3beta/Axin] interactions in *response* to leads to the initial stabilization of beta-catenin and that Galpha ( o ) and Galpha ( q ) signaling contributes to Wnt mediated GSK3beta/Axin disruption and the ultimate stabilization of beta-catenin . Regulation AXIN2 WNT1 22191557 2543433 Because [Axin] *controls* canonical signaling , we conducted an investigation to determine whether the cardiogenic activity of 1 is Wnt dependent , and we developed a structure-activity relationship to optimize the cardiogenic properties of 1 . Regulation AXIN2 WNT1 22322943 2592182 signalling regulates cell proliferation by modulating the cell cycle and is negatively *regulated* by [conductin/axin2/axil] . Regulation AXIN2 WNT1 23409032 2743955 Accordingly , we observed a decrease in *dependent* luciferase reporter activity as well as a decreased expression of [AXIN2] representing an endogenous ß-catenin target gene . Regulation AXIN2 WNT11 10906131 743681 In L cells where APC is intact , Axin ( delta ) ( beta)(-catenin ) inhibited *dependent* accumulation of beta-catenin but not [Axin-] ( 298-832 ) ( delta ) ( beta)(-catenin ) in which the APC- and beta-catenin binding sites are deleted . Regulation AXIN2 WNT11 11809809 906825 signaling is *controlled* by the negative regulator [conductin/axin2/axil] , which induces degradation of beta-catenin by functional interaction with the tumor suppressor APC and the serine/threonine kinase GSK3beta . Regulation AXIN2 WNT11 12636920 1068524 [Axin2] , a negative regulator of the Wnt pathway , is directly *controlled* by and shows oscillating expression in the PSM , even when Notch signaling is impaired , alternating with Lfng expression . Regulation AXIN2 WNT11 16303557 1485444 Finally , we demonstrate an association of Galpha ( o ) with Fz that is also very rapidly ( t1/2 < 1 min ) perturbed upon Wnt-3a stimulation and that the dependent *effects* on both [GSK3beta/Axin2] and Galpha ( o ) /Fz are pertussis-toxin sensitive . Regulation AXIN2 WNT11 16303557 1485489 We conclude that rapid disruption of [GSK3beta/Axin] interactions in *response* to leads to the initial stabilization of beta-catenin and that Galpha ( o ) and Galpha ( q ) signaling contributes to Wnt mediated GSK3beta/Axin disruption and the ultimate stabilization of beta-catenin . Regulation AXIN2 WNT11 17202189 1680727 In the full-grown oocyte , before maturation , we find that [axin] levels are also *regulated* by and LRP6 . Regulation AXIN2 WNT11 17202189 1680737 In the oocyte , and/or LRP6 *regulates* [axin] to maintain beta-catenin at a low level , while in the embryo , asymmetrical Wnt11/LRP6 signaling stabilizes beta-catenin and enriches it on the dorsal side . Regulation AXIN2 WNT11 22191557 2543434 Because [Axin] *controls* canonical signaling , we conducted an investigation to determine whether the cardiogenic activity of 1 is Wnt dependent , and we developed a structure-activity relationship to optimize the cardiogenic properties of 1 . Regulation AXIN2 WNT11 22322943 2592183 signalling regulates cell proliferation by modulating the cell cycle and is negatively *regulated* by [conductin/axin2/axil] . Regulation AXIN2 WNT11 23409032 2743956 Accordingly , we observed a decrease in *dependent* luciferase reporter activity as well as a decreased expression of [AXIN2] representing an endogenous ß-catenin target gene . Regulation AXIN2 WNT16 10906131 743686 In L cells where APC is intact , Axin ( delta ) ( beta)(-catenin ) inhibited *dependent* accumulation of beta-catenin but not [Axin-] ( 298-832 ) ( delta ) ( beta)(-catenin ) in which the APC- and beta-catenin binding sites are deleted . Regulation AXIN2 WNT16 11809809 906830 signaling is *controlled* by the negative regulator [conductin/axin2/axil] , which induces degradation of beta-catenin by functional interaction with the tumor suppressor APC and the serine/threonine kinase GSK3beta . Regulation AXIN2 WNT16 12636920 1068529 [Axin2] , a negative regulator of the Wnt pathway , is directly *controlled* by and shows oscillating expression in the PSM , even when Notch signaling is impaired , alternating with Lfng expression . Regulation AXIN2 WNT16 16303557 1485449 Finally , we demonstrate an association of Galpha ( o ) with Fz that is also very rapidly ( t1/2 < 1 min ) perturbed upon Wnt-3a stimulation and that the *dependent* effects on both [GSK3beta/Axin2] and Galpha ( o ) /Fz are pertussis-toxin sensitive . Regulation AXIN2 WNT16 16303557 1485494 We conclude that rapid disruption of [GSK3beta/Axin] interactions in *response* to leads to the initial stabilization of beta-catenin and that Galpha ( o ) and Galpha ( q ) signaling contributes to Wnt mediated GSK3beta/Axin disruption and the ultimate stabilization of beta-catenin . Regulation AXIN2 WNT16 22191557 2543439 Because [Axin] *controls* canonical signaling , we conducted an investigation to determine whether the cardiogenic activity of 1 is Wnt dependent , and we developed a structure-activity relationship to optimize the cardiogenic properties of 1 . Regulation AXIN2 WNT16 22322943 2592188 signalling regulates cell proliferation by modulating the cell cycle and is negatively *regulated* by [conductin/axin2/axil] . Regulation AXIN2 WNT16 23409032 2743961 Accordingly , we observed a decrease in *dependent* luciferase reporter activity as well as a decreased expression of [AXIN2] representing an endogenous ß-catenin target gene . Regulation AXIN2 WNT2 10906131 743682 In L cells where APC is intact , Axin ( delta ) ( beta)(-catenin ) inhibited *dependent* accumulation of beta-catenin but not [Axin-] ( 298-832 ) ( delta ) ( beta)(-catenin ) in which the APC- and beta-catenin binding sites are deleted . Regulation AXIN2 WNT2 11809809 906826 signaling is *controlled* by the negative regulator [conductin/axin2/axil] , which induces degradation of beta-catenin by functional interaction with the tumor suppressor APC and the serine/threonine kinase GSK3beta . Regulation AXIN2 WNT2 12636920 1068525 [Axin2] , a negative regulator of the Wnt pathway , is directly *controlled* by and shows oscillating expression in the PSM , even when Notch signaling is impaired , alternating with Lfng expression . Regulation AXIN2 WNT2 16303557 1485445 Finally , we demonstrate an association of Galpha ( o ) with Fz that is also very rapidly ( t1/2 < 1 min ) perturbed upon Wnt-3a stimulation and that the *dependent* effects on both [GSK3beta/Axin2] and Galpha ( o ) /Fz are pertussis-toxin sensitive . Regulation AXIN2 WNT2 16303557 1485490 We conclude that rapid disruption of [GSK3beta/Axin] interactions in *response* to leads to the initial stabilization of beta-catenin and that Galpha ( o ) and Galpha ( q ) signaling contributes to Wnt mediated GSK3beta/Axin disruption and the ultimate stabilization of beta-catenin . Regulation AXIN2 WNT2 22191557 2543435 Because [Axin] *controls* canonical signaling , we conducted an investigation to determine whether the cardiogenic activity of 1 is Wnt dependent , and we developed a structure-activity relationship to optimize the cardiogenic properties of 1 . Regulation AXIN2 WNT2 22322943 2592184 signalling regulates cell proliferation by modulating the cell cycle and is negatively *regulated* by [conductin/axin2/axil] . Regulation AXIN2 WNT2 23409032 2743957 Accordingly , we observed a decrease in *dependent* luciferase reporter activity as well as a decreased expression of [AXIN2] representing an endogenous ß-catenin target gene . Regulation AXIN2 WNT3 10906131 743683 In L cells where APC is intact , Axin ( delta ) ( beta)(-catenin ) inhibited *dependent* accumulation of beta-catenin but not [Axin-] ( 298-832 ) ( delta ) ( beta)(-catenin ) in which the APC- and beta-catenin binding sites are deleted . Regulation AXIN2 WNT3 11809809 906827 signaling is *controlled* by the negative regulator [conductin/axin2/axil] , which induces degradation of beta-catenin by functional interaction with the tumor suppressor APC and the serine/threonine kinase GSK3beta . Regulation AXIN2 WNT3 12636920 1068526 [Axin2] , a negative regulator of the Wnt pathway , is directly *controlled* by and shows oscillating expression in the PSM , even when Notch signaling is impaired , alternating with Lfng expression . Regulation AXIN2 WNT3 16303557 1485446 Finally , we demonstrate an association of Galpha ( o ) with Fz that is also very rapidly ( t1/2 < 1 min ) perturbed upon Wnt-3a stimulation and that the dependent *effects* on both [GSK3beta/Axin2] and Galpha ( o ) /Fz are pertussis-toxin sensitive . Regulation AXIN2 WNT3 16303557 1485491 We conclude that rapid disruption of [GSK3beta/Axin] interactions in *response* to leads to the initial stabilization of beta-catenin and that Galpha ( o ) and Galpha ( q ) signaling contributes to Wnt mediated GSK3beta/Axin disruption and the ultimate stabilization of beta-catenin . Regulation AXIN2 WNT3 22191557 2543436 Because [Axin] *controls* canonical signaling , we conducted an investigation to determine whether the cardiogenic activity of 1 is Wnt dependent , and we developed a structure-activity relationship to optimize the cardiogenic properties of 1 . Regulation AXIN2 WNT3 22322943 2592185 signalling regulates cell proliferation by modulating the cell cycle and is negatively *regulated* by [conductin/axin2/axil] . Regulation AXIN2 WNT3 23409032 2743958 Accordingly , we observed a decrease in *dependent* luciferase reporter activity as well as a decreased expression of [AXIN2] representing an endogenous ß-catenin target gene . Regulation AXIN2 WNT4 10906131 743684 In L cells where APC is intact , Axin ( delta ) ( beta)(-catenin ) inhibited *dependent* accumulation of beta-catenin but not [Axin-] ( 298-832 ) ( delta ) ( beta)(-catenin ) in which the APC- and beta-catenin binding sites are deleted . Regulation AXIN2 WNT4 11809809 906828 signaling is *controlled* by the negative regulator [conductin/axin2/axil] , which induces degradation of beta-catenin by functional interaction with the tumor suppressor APC and the serine/threonine kinase GSK3beta . Regulation AXIN2 WNT4 12636920 1068527 [Axin2] , a negative regulator of the Wnt pathway , is directly *controlled* by and shows oscillating expression in the PSM , even when Notch signaling is impaired , alternating with Lfng expression . Regulation AXIN2 WNT4 16303557 1485447 Finally , we demonstrate an association of Galpha ( o ) with Fz that is also very rapidly ( t1/2 < 1 min ) perturbed upon Wnt-3a stimulation and that the *dependent* effects on both [GSK3beta/Axin2] and Galpha ( o ) /Fz are pertussis-toxin sensitive . Regulation AXIN2 WNT4 16303557 1485492 We conclude that rapid disruption of [GSK3beta/Axin] interactions in *response* to leads to the initial stabilization of beta-catenin and that Galpha ( o ) and Galpha ( q ) signaling contributes to Wnt mediated GSK3beta/Axin disruption and the ultimate stabilization of beta-catenin . Regulation AXIN2 WNT4 22191557 2543437 Because [Axin] *controls* canonical signaling , we conducted an investigation to determine whether the cardiogenic activity of 1 is Wnt dependent , and we developed a structure-activity relationship to optimize the cardiogenic properties of 1 . Regulation AXIN2 WNT4 22322943 2592186 signalling regulates cell proliferation by modulating the cell cycle and is negatively *regulated* by [conductin/axin2/axil] . Regulation AXIN2 WNT4 23370438 2809604 Exogenously added significantly increased CXCL8/IL-8 , IL-6 , CCL5/RANTES , CCL2/MCP-1 and vascular endothelial growth factor ( VEGF ) secretion in 16HBE , but did not *affect* the canonical WNT target genes MMP-2 , MMP-9 , fibronectin , ß-catenin , Dickkopf and [axin-2] , and induced activation of the non-canonical signalling molecule p38 . Regulation AXIN2 WNT4 23409032 2743959 Accordingly , we observed a decrease in *dependent* luciferase reporter activity as well as a decreased expression of [AXIN2] representing an endogenous ß-catenin target gene . Regulation AXIN2 WNT6 10906131 743685 In L cells where APC is intact , Axin ( delta ) ( beta)(-catenin ) inhibited *dependent* accumulation of beta-catenin but not [Axin-] ( 298-832 ) ( delta ) ( beta)(-catenin ) in which the APC- and beta-catenin binding sites are deleted . Regulation AXIN2 WNT6 11809809 906829 signaling is *controlled* by the negative regulator [conductin/axin2/axil] , which induces degradation of beta-catenin by functional interaction with the tumor suppressor APC and the serine/threonine kinase GSK3beta . Regulation AXIN2 WNT6 12636920 1068528 [Axin2] , a negative regulator of the Wnt pathway , is directly *controlled* by and shows oscillating expression in the PSM , even when Notch signaling is impaired , alternating with Lfng expression . Regulation AXIN2 WNT6 16303557 1485448 Finally , we demonstrate an association of Galpha ( o ) with Fz that is also very rapidly ( t1/2 < 1 min ) perturbed upon Wnt-3a stimulation and that the dependent *effects* on both [GSK3beta/Axin2] and Galpha ( o ) /Fz are pertussis-toxin sensitive . Regulation AXIN2 WNT6 16303557 1485493 We conclude that rapid disruption of [GSK3beta/Axin] interactions in *response* to leads to the initial stabilization of beta-catenin and that Galpha ( o ) and Galpha ( q ) signaling contributes to Wnt mediated GSK3beta/Axin disruption and the ultimate stabilization of beta-catenin . Regulation AXIN2 WNT6 22191557 2543438 Because [Axin] *controls* canonical signaling , we conducted an investigation to determine whether the cardiogenic activity of 1 is Wnt dependent , and we developed a structure-activity relationship to optimize the cardiogenic properties of 1 . Regulation AXIN2 WNT6 22322943 2592187 signalling regulates cell proliferation by modulating the cell cycle and is negatively *regulated* by [conductin/axin2/axil] . Regulation AXIN2 WNT6 23409032 2743960 Accordingly , we observed a decrease in *dependent* luciferase reporter activity as well as a decreased expression of [AXIN2] representing an endogenous ß-catenin target gene . Regulation B4GALT1 TNF 17917074 1804097 The *role* of and its receptors in the production of [beta-1,4 galactosyltransferase I] and V mRNAs by rat primary astrocytes . Regulation B9D2 STK39 18083840 1837722 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation BAAT IL1B 2783532 106899 These data indicate that the central *effects* of on metabolic rate , body temperature , [BAT] activity , and white blood cell count are all mediated by release of CRF . Regulation BACE1 IL1B 12878199 1115533 To investigate factors that stimulate BACE protein expression in astrocytes , we tested the *effects* of and interferon-gamma (IFN-gamma) on [BACE] protein expression in U373MG astrocytoma cells and primary astrocyte cultures from Tg2576 mouse brains . Regulation BACE1 PCSK9 20453200 2300987 is not *involved* in the degradation of LDL receptors and [BACE1] in the adult mouse brain . Regulation BACE1 PCSK9 20453200 2300992 In addition , we found no evidence that *regulates* [BACE1] levels or APP processing in the mouse brain . Regulation BACE1 PGC 21358044 2463485 These effects appeared to be dependent on PPAR? , because did not *affect* Aß and [BACE1] levels in N2a cells transfected with PPAR? siRNA or in PPAR? knockout fibroblasts . Regulation BAMBI TNF 24448807 2932992 In human HSCs , [BAMBI] expression was down-regulated in *response* to LPS and . Regulation BANF1 IL1B 1334680 205896 Neither IL-1 alpha nor *affected* the [PIC] activity of membrane or cytosolic fractions . Regulation BANF1 ITGB2 10858245 704669 In this study , we investigated whether deficiency in cattle *affects* [proinflammatory cytokine (PIC)] expression in pulmonary tissue after respiratory infection with Pasteurella haemolytica . Regulation BAX CAPN8 10075737 595081 We have previously demonstrated that is *responsible* for the cleavage of [Bax] , a proapoptotic protein , during drug induced apoptosis of HL-60 cells ( Wood , D. E. , Thomas , A. , Devi , L. A. , Berman , Y. , Beavis , R. C. , Reed , J. C. , and Newcomb , E. W. ( 1998 ) Oncogene 17 , 1069-1078 ) . Regulation BAX CDKN1C 22705236 2633869 Indeed , the expression of [Bax] , Noxa , PUMA , BNIP(3) , and cleaved caspase-3 was not *affected* by induction . Regulation BAX FAS 9163609 432095 In conclusion , our results suggest a p53 independent co-regulation of and Bax , as well as a *role* for [Bax] in Apo-1/Fas induced apoptosis in myeloma . Regulation BAX ID1 18158619 1971444 *regulates* Bcl-2 and [Bax] expression through p53 and NF-kappaB in MCF-7 breast cancer cells . Regulation BAX ID1 20945346 2389308 *regulated* the expression levels of anti-apoptotic Bcl-2 and pro-apoptotic [Bax] , and resulted in delay of apoptotic peak during postlactational involution . Regulation BAX IFI27 21063843 2344977 *Effects* of gene transfer on the expression of [Bax] , Bcl-2 , VEGF and MMP-9 in the transplanted liver tumors in nude mice . Regulation BAX LBP 19735167 2134516 The ratio of Bcl-2/Bax protein expression following LBP treatments decreased significantly with a dose-effect relationship , which suggested that can *regulate* the expression of Bcl-2 and [Bax] to induce apoptosis of PC-3 and DU-145 cells . Regulation BAX MAP2K6 11842081 929186 In contrast , both U0126 , a MEK inhibitor , and active had little *effect* on [Bax] localization . Regulation BAX MAP2K6 16414356 1514457 Regulation by sphingosine 1-phosphate of [Bax] and Bad activities during apoptosis in a *dependent* manner . Regulation BAX TNF 11097743 755793 However , did not *affect* the levels of the [Bax] protein , which also has p53 binding sites on its promoter and causes apoptosis . Regulation BBC3 TNF 19444283 2114793 In this study , we found that [p53 upregulated modulator of apoptosis] ( PUMA ) , a p53 downstream target and a BH3-only Bcl-2 family member , is directly regulated by NF-kappaB in *response* to . Regulation BCL10 CAPN8 19220664 2114158 Na+/H+ exchanger mediates TNF-alpha induced hepatocyte apoptosis via the *dependent* degradation of [Bcl-xL] . Regulation BCL10 EPHB2 16007395 1431332 The inhibition of phosphorylation by a specific inhibitor , PD98059 , did not *affect* the increase in [Bcl-xL] expression level . Regulation BCL10 MMP28 20347949 2281822 Moreover , MWG extract decreased the level of intracellular reactive oxygen species ( ROS ) , increased , *regulated* Bcl-2 family protein expression ( Bcl-2 and [Bcl-XL] ) and inhibited the release of cytochrome c from the mitochondria . Regulation BCL10 MMP7 20347949 2281837 Moreover , MWG extract decreased the level of intracellular reactive oxygen species ( ROS ) , increased , *regulated* Bcl-2 family protein expression ( Bcl-2 and [Bcl-XL] ) and inhibited the release of cytochrome c from the mitochondria . Regulation BCL2 CAPN8 19220664 2114172 Na+/H+ exchanger mediates TNF-alpha induced hepatocyte apoptosis via the *dependent* degradation of [Bcl-xL] . Regulation BCL2 CAPN8 19782128 2264341 Nuclear translocation and *dependent* reduction of [Bcl-2] after neonatal cerebral hypoxia-ischemia . Regulation BCL2 EPHB2 10097113 601587 By contrast , neither an inhibitor ( PD098059 ) nor p38 inhibitors ( SB203580 and SB202190 ) had an *effect* on [Bcl-2] phosphorylation . Regulation BCL2 EPHB2 15225643 1268303 The phosphorylation status and anti-apoptotic activity of [Bcl-2] are *regulated* by and protein phosphatase 2A on the mitochondria . Regulation BCL2 EPHB2 15935058 1414836 FGF-2 treatment caused an *dependent* increase in [Bcl-2] and an ERK independent increase in Bcl-x ( L ) . Regulation BCL2 EPHB2 16007395 1431333 The inhibition of phosphorylation by a specific inhibitor , PD98059 , did not *affect* the increase in [Bcl-xL] expression level . Regulation BCL2 EPHB2 16251184 1489677 Wnt3a increased the expression of the anti-apoptotic protein [Bcl-2] in an *dependent* manner . Regulation BCL2 EPHB2 18438930 1932671 Thus , *dependent* p35 up-regulation and MAPK/ERK dependent and PI3K/Akt dependent [Bcl2] up-regulation contribute to BDNF stimulated neural differentiation and to the survival of differentiated cells . Regulation BCL2 EPHB2 18677583 2011574 Evidence for *involvement* of , PI3K , and RSK in induction of [Bcl-2] by valproate . Regulation BCL2 EPHB2 19062038 2156932 Finally , the *effect* of the inhibitor ( PD98059 ) on [BCL-2] expression and induction of anoikis was examined . Regulation BCL2 FAS 12915385 1129934 These changes in the ligand pathway and [Bcl-2] mitochondrial apoptosis *regulation* are enhanced by complete suppression of antiapoptotic FADD-like IL-1beta converting enzyme inhibitory protein ( FLIP ) ( from 30.5 to 0.0 % , P < 0.01 ) and Bcl-xL ( from 22.5 to 0.1 % , P = 0.03 ) expression among these cells from the earliest days after gene transfer . Regulation BCL2 FAS 16120269 895997 Using a stable transfected CEM cell line , we show that [Bcl-2] suppressed caspase processing in both cytosolic and mitochondrial compartments in *response* to both staurosporine and ligation . Regulation BCL2 ID1 18158619 1971445 *regulates* [Bcl-2] and Bax expression through p53 and NF-kappaB in MCF-7 breast cancer cells . Regulation BCL2 ID1 20945346 2389309 *regulated* the expression levels of anti-apoptotic [Bcl-2] and pro-apoptotic Bax , and resulted in delay of apoptotic peak during postlactational involution . Regulation BCL2 LBP 19735167 2134517 The ratio of Bcl-2/Bax protein expression following LBP treatments decreased significantly with a dose-effect relationship , which suggested that can *regulate* the expression of [Bcl-2] and Bax to induce apoptosis of PC-3 and DU-145 cells . Regulation BCL2 MAOA 22065207 2567963 The novel *role* of in [Bcl-2] induction by rasagiline is discussed with regard to the molecular mechanism underlying neuroprotection by the MAO inhibitors . Regulation BCL2 MMP28 20347949 2281844 Moreover , MWG extract decreased the level of intracellular reactive oxygen species ( ROS ) , increased , *regulated* Bcl-2 family protein expression ( Bcl-2 and [Bcl-XL] ) and inhibited the release of cytochrome c from the mitochondria . Regulation BCL2 MMP7 20347949 2281859 Moreover , MWG extract decreased the level of intracellular reactive oxygen species ( ROS ) , increased , *regulated* [Bcl-2] family protein expression ( Bcl-2 and Bcl-XL ) and inhibited the release of cytochrome c from the mitochondria . Regulation BCL2 PECAM1 9252201 446927 [Bcl-2] expression was *independent* of and cathepsin D expression . Regulation BCL2 TNF 11971816 933671 The *effect* of on [Bcl-2] serine phosphorylation was blocked by IGFBP-3 antisense oligomers . Regulation BCL2 TNF 12077131 976077 Dantrolene suppressed the inhibitory *effect* of on [Bcl-2] expression . Regulation BCL2 TNF 12297009 991032 Accordingly , [Bcl-2] , an anti-apoptotic Bcl-2 family member , was highly expressed in *response* to . Regulation BCL2 TNF 23174100 2700545 Our results showed that TNF-alpha treatment increased Bcl-2 mRNA and protein levels in breast cancer cells , suggesting that [Bcl-2] is directly regulated by nuclear factor-kappaB (NF-kappaB) in *response* to . Regulation BCL2 TNF 23339680 2738494 In the study , we designed to investigate the *effect* of on the activation and expression of nuclear factor kappa B ( NF-?B ) [/p65/SLUG/PUMA/Bcl-2] levels in human lung cancer A549 cell line , and in conditions of TNF-a induced apoptosis . Regulation BCL2 TNF 23421021 2713893 [ Higher incidence of alveolar lymphocytes ( AL ) apoptosis in smokers depends on [BCL-2] expression and specific *response* to . Regulation BCL2 TNFSF10 10760520 683618 Thus , engages a death pathway that is at least partially routed via the mitochondria , but in contrast with other stimuli that engage this pathway , TRAIL induced cytochrome c release is not *regulated* by [Bcl-2] . Regulation BCL2 TNFSF10 12917026 1130063 However , and doxorubicin did not *affect* p53 and [Bcl-2] protein expression . Regulation BCL3 CAPN8 19220664 2114186 Na+/H+ exchanger mediates TNF-alpha induced hepatocyte apoptosis via the *dependent* degradation of [Bcl-xL] . Regulation BCL3 EPHB2 16007395 1431334 The inhibition of phosphorylation by a specific inhibitor , PD98059 , did not *affect* the increase in [Bcl-xL] expression level . Regulation BCL3 MMP28 20347949 2281866 Moreover , MWG extract decreased the level of intracellular reactive oxygen species ( ROS ) , increased , *regulated* Bcl-2 family protein expression ( Bcl-2 and [Bcl-XL] ) and inhibited the release of cytochrome c from the mitochondria . Regulation BCL3 MMP7 20347949 2281881 Moreover , MWG extract decreased the level of intracellular reactive oxygen species ( ROS ) , increased , *regulated* Bcl-2 family protein expression ( Bcl-2 and [Bcl-XL] ) and inhibited the release of cytochrome c from the mitochondria . Regulation BCL3 TNF 24130828 2853356 Here , we define an Incoherent Feed-forward Loop motif in which TNFa induced NF-?B signalling activates expression of the gene itself and also *controls* synthesis of the negative regulator [BCL-3] . Regulation BCL5 CAPN8 19220664 2114116 Na+/H+ exchanger mediates TNF-alpha induced hepatocyte apoptosis via the *dependent* degradation of [Bcl-xL] . Regulation BCL5 EPHB2 16007395 1431329 The inhibition of phosphorylation by a specific inhibitor , PD98059 , did not *affect* the increase in [Bcl-xL] expression level . Regulation BCL5 MMP28 20347949 2281756 Moreover , MWG extract decreased the level of intracellular reactive oxygen species ( ROS ) , increased , *regulated* Bcl-2 family protein expression ( Bcl-2 and [Bcl-XL] ) and inhibited the release of cytochrome c from the mitochondria . Regulation BCL5 MMP7 20347949 2281771 Moreover , MWG extract decreased the level of intracellular reactive oxygen species ( ROS ) , increased , *regulated* Bcl-2 family protein expression ( Bcl-2 and [Bcl-XL] ) and inhibited the release of cytochrome c from the mitochondria . Regulation BCL6 CAPN8 19220664 2114130 Na+/H+ exchanger mediates TNF-alpha induced hepatocyte apoptosis via the *dependent* degradation of [Bcl-xL] . Regulation BCL6 EPHB2 16007395 1431330 The inhibition of phosphorylation by a specific inhibitor , PD98059 , did not *affect* the increase in [Bcl-xL] expression level . Regulation BCL6 MMP28 20347949 2281778 Moreover , MWG extract decreased the level of intracellular reactive oxygen species ( ROS ) , increased , *regulated* Bcl-2 family protein expression ( Bcl-2 and [Bcl-XL] ) and inhibited the release of cytochrome c from the mitochondria . Regulation BCL6 MMP7 20347949 2281793 Moreover , MWG extract decreased the level of intracellular reactive oxygen species ( ROS ) , increased , *regulated* Bcl-2 family protein expression ( Bcl-2 and [Bcl-XL] ) and inhibited the release of cytochrome c from the mitochondria . Regulation BCL9 CAPN8 19220664 2114144 Na+/H+ exchanger mediates TNF-alpha induced hepatocyte apoptosis via the *dependent* degradation of [Bcl-xL] . Regulation BCL9 EPHB2 16007395 1431331 The inhibition of phosphorylation by a specific inhibitor , PD98059 , did not *affect* the increase in [Bcl-xL] expression level . Regulation BCL9 MMP28 20347949 2281800 Moreover , MWG extract decreased the level of intracellular reactive oxygen species ( ROS ) , increased , *regulated* Bcl-2 family protein expression ( Bcl-2 and [Bcl-XL] ) and inhibited the release of cytochrome c from the mitochondria . Regulation BCL9 MMP7 20347949 2281815 Moreover , MWG extract decreased the level of intracellular reactive oxygen species ( ROS ) , increased , *regulated* Bcl-2 family protein expression ( Bcl-2 and [Bcl-XL] ) and inhibited the release of cytochrome c from the mitochondria . Regulation BCR CD22 12055217 951721 Moreover , in CD22-deficient mice , anti-IgM treatment did not trigger enhanced Ca ( 2+ ) influx in CD5 ( + ) B-1 cells , unlike CD22-deficient splenic B-2 cells , suggesting a relatively limited *role* of in [BCR] signaling in B-1 cells . Regulation BCR CD22 16497829 1535283 This points to a new mechanism of [BCR] signal *regulation* by and its ligand . Regulation BCR CD22 17223015 1703657 CD19 and do not merely *regulate* [BCR] signals independently , but they have their own regulatory network . Regulation BCR CD22 17631277 1775242 Previous studies demonstrated that synthetic sialosides that bind to CD22 augment BCR signaling by inhibiting mediated [BCR] *regulation* . Regulation BCR CD22 18024433 1851816 We demonstrate that the mutant in which both Tyr ( 843 ) and Tyr ( 863 ) are replaced by phenylalanine ( CD22F5/6 ) recruits SHP-1 and *regulates* [BCR] signaling upon stimulation with antigen but not anti-Ig Ab . Regulation BCR CD22 9371816 466177 Ligation of CD19 and in vivo is likely to positively and negatively *regulate* [BCR] signaling , respectively , because CD19 crosslinking was more efficient than BCR crosslinking at inducing Vav phosphorylation . Regulation BCR EPHB2 24958853 2947339 Our findings indicate that in immature B cells , basal activation of Ras and are *controlled* by tonic [BCR] signaling , and that positive changes in Ras activity can lead to a break in both central and peripheral B-cell tolerance . Regulation BCR IFI27 11920258 894493 This enhanced [BCR/ABL] mediated growth inhibition occurred over a range of growth factor concentrations and was *independent* of changes in p21(Cip1) and ( Kip ) levels . Regulation BCR PECAM1 23233201 2724498 is *involved* in [BCR/ABL] signaling and may downregulate imatinib induced apoptosis of Philadelphia chromosome positive leukemia cells . Regulation BCR TGM2 19840940 2170047 *regulates* the GTPase activating activity of [Bcr] . Regulation BCR TGM2 21310073 2393315 *regulates* [Bcr] by direct binding to its GAP domain . Regulation BCR TLR7 18228247 1864205 To address this goal , we examined the *effects* of stimulation on [BCR] and CD40 induced B cell activation . Regulation BCR TLR7 19890051 2165959 After coculture of autoreactive B cells that recognize self-Ag small nuclear ribonucleoprotein particles with activated pDCs , we found that pDCs significantly enhance autoreactive B cell proliferation , autoantibody production , and survival in *response* to and [BCR] stimulation . Regulation BCRP1 PDZK1 21816982 2495522 Taken together , these findings demonstrate that *plays* a pivotal role in the apical localization of [BCRP] . Regulation BCRP2 PDZK1 21816982 2495518 Taken together , these findings demonstrate that *plays* a pivotal role in the apical localization of [BCRP] . Regulation BCRP3 PDZK1 21816982 2495519 Taken together , these findings demonstrate that *plays* a pivotal role in the apical localization of [BCRP] . Regulation BCRP4 PDZK1 21816982 2495520 Taken together , these findings demonstrate that *plays* a pivotal role in the apical localization of [BCRP] . Regulation BCRP5 PDZK1 21816982 2495521 Taken together , these findings demonstrate that *plays* a pivotal role in the apical localization of [BCRP] . Regulation BCRP6 PDZK1 21816982 2495523 Taken together , these findings demonstrate that *plays* a pivotal role in the apical localization of [BCRP] . Regulation BCRP7 PDZK1 21816982 2495524 Taken together , these findings demonstrate that *plays* a pivotal role in the apical localization of [BCRP] . Regulation BCRP8 PDZK1 21816982 2495525 Taken together , these findings demonstrate that *plays* a pivotal role in the apical localization of [BCRP] . Regulation BCRP9 PDZK1 21816982 2495526 Taken together , these findings demonstrate that *plays* a pivotal role in the apical localization of [BCRP] . Regulation BDNF EPHB2 15469046 1305871 We observed that the signalling *regulates* the [brain derived neurotrophic factor (BDNF)] expression in DRG neurons in both conditions . Regulation BDNF EPHB2 20739478 2401386 Dissection of the intracellular pathway that underlies this process revealed that [BDNF/TrkB] signaling controls the transcription of GAD65 in a *dependent* manner . Regulation BDNF EPHB2 22309829 2565343 Taken together , EP1 and EP4 receptor subtypes , PKA , and CREB signaling pathways as well as NGF are *involved* in PGE2 induced [BDNF] synthesis in DRG neurons . Regulation BDNF EPHB2 22820234 2660334 Curcumin produces antidepressant effects via activating *dependent* [brain derived neurotrophic factor] expression in the amygdala of mice . Regulation BDNF EPHB2 22820234 2660347 These results suggest that the antidepressant-like effects of curcumin in the forced swim test are mediated , at least in part , by an *regulated* increase of [BDNF] expression in the amygdala of mice . Regulation BDNF EPHB2 23035088 2684522 Extinction of aversive memories associated with morphine withdrawal requires mediated epigenetic *regulation* of [brain derived neurotrophic factor] transcription in the rat ventromedial prefrontal cortex . Regulation BDNF IL1B 16621158 1598392 *regulation* of [BDNF] expression in rat cultured hypothalamic neurons depends on the presence of glial cells . Regulation BDNF IL1B 16621158 1598395 Notably , we investigated whether *affected* [BDNF] expression in vitro either on hypothalamic mixed cultures or on neuron enriched cultures . Regulation BDNF IL1B 16621158 1598396 Indomethacin blocked both stimulatory and inhibitory *effects* on [BDNF] mRNA expression whereas picrotoxin ( a GABA ( A ) blocker ) or MK-801 ( a NMDA receptor blocker ) had no effect on BDNF mRNA levels . Regulation BDNF TNF 10517960 652376 In this study we used two lines of transgenic mice overexpressing tumor necrosis factor alpha (TNF-alpha) in the central nervous system ( CNS ) , one characterized by reactive gliosis , inflammatory demyelination and neurological deficits ( Tg6074 ) the other showing no neurological or phenotypical alterations ( TgK3 ) to investigate the *effect* of on brain nerve growth factor (NGF) and [brain derived neurotrophic factor (BDNF)] levels and learning abilities . Regulation BDNF TNF 15710474 1373500 and interleukin-6 *regulate* secretion of [brain derived neurotrophic factor] in human monocytes . Regulation BDNF TNF 20690185 2368101 In this study , we investigated the *effects* of inflammatory cytokines , IL-1ß , and , on the expression of an angiogenic factor , vascular endothelial growth factor ( VEGF ) , and neurotrophic factors , nerve growth factor (NGF) and [brain derived neurotrophic factor (BDNF)] , in human IVD degeneration . Regulation BDNF TNF 22974557 2697849 Real-time RT-PCR and Western blotting indicated that ES which was applied to different co-cultures and 661W cell conditioned media ( 661WCM ) -treated glia cultures had a prominent inhibitive effect on the secretion of interleukin (IL)-1ß and in microglia and a positive regulative *effect* on the production of [brain derived neurotrophic factor (BDNF)] and ciliary neurotrophic factor (CNTF) in Müller cells . Regulation BECN1 EPHB2 19520853 2116153 Our findings thus propose that the pathway *regulation* of [Beclin 1] represents different thresholds responsible for a protective or destructive autophagy . Regulation BECN1 MAP2K6 19520853 2116160 Our findings thus propose that the pathway *regulation* of [Beclin 1] represents different thresholds responsible for a protective or destructive autophagy . Regulation BECN1 TNF 16942488 1609459 We assessed the *effect* of and insulin-like growth factor-1 (IGF-1) on the expression of autophagic genes , microtubule associated protein 1 light chain 3 ( MAPLC-3 ) and [Beclin-1] in VSMC isolated from atherosclerotic plaques . Regulation BGLAP FOXO1 21471200 2433549 In this study , we determined the molecular mechanisms whereby forkhead transcription factor , a key downstream signaling molecule of insulin-like growth factor 1 (IGF1)/insulin actions , *regulates* Runx2 activity and expression of the mouse [osteocalcin] gene 2 ( Bglap2 ) in osteoblasts in vitro . Regulation BGLAP GPR115 21333348 2399290 By binding to a expressed in the Leydig cells of the testes , [osteocalcin] *regulates* in a CREB dependent manner the expression of enzymes that is required for testosterone synthesis , promoting germ cell survival . Regulation BGLAP GPR132 21333348 2399279 By binding to a expressed in the Leydig cells of the testes , [osteocalcin] *regulates* in a CREB dependent manner the expression of enzymes that is required for testosterone synthesis , promoting germ cell survival . Regulation BGLAP GPR87 21333348 2399361 By binding to a expressed in the Leydig cells of the testes , [osteocalcin] *regulates* in a CREB dependent manner the expression of enzymes that is required for testosterone synthesis , promoting germ cell survival . Regulation BGLAP IL1B 11934644 927813 and ( iv ) reverses *dependent* suppression of [osteocalcin] and alkaline phosphatase synthesis . Regulation BGLAP IL1B 12375736 996725 *regulates* cellular proliferation , prostaglandin E2 synthesis , plasminogen activator activity , [osteocalcin] production , and bone resorptive activity of the mouse calvarial bone cells . Regulation BGLAP IL1B 2302203 127732 The *effects* of recombinant human on cellular proliferation and the production of prostaglandin E2 , plasminogen activator , [osteocalcin] and alkaline phosphatase by osteoblast-like cells derived from human bone . Regulation BGLAP NT5E 18980528 1983318 We examined how *regulates* the mRNA expression of bone/cementum related proteins ( alkaline phosphatase [ ALPase ] , osteopontin [ OPN ] , [osteocalcin] [ OC ] , and bone morphogenetic protein [ BMP]-2 ) in cultures of HPL cells . Regulation BGLAP RARB 9113387 426012 These results suggested that the inhibitory effect of RA on the mineralization of human osteoblasts is mediated by the activation of RAR alpha and/or and that RAR gamma preferentially *regulates* the expression of [osteocalcin] without influence on mineralization . Regulation BGLAP TNF 11165942 782905 In addition , inhibition of p38 MAPK partially , but significantly , impaired *regulated* release of [osteocalcin] , an important differentiation marker in osteoblasts . Regulation BGLAP TNF 2019266 157116 To further test this hypothesis and to evaluate the mechanism of TNF alpha action , we studied the *effect* of on synthesis of the osteoblast-specific [bone Gla protein (BGP)] by ROS 17/2.8 cells , which have the osteoblast phenotype . Regulation BGLAP TNF 2019266 157119 The *effect* of on steady state [BGP] mRNA levels was not prevented by treatment of cells with cycloheximide , suggesting that TNF induced new protein synthesis was not required for TNF alpha action . Regulation BGLAP TNF 20638987 2292251 Of note , the inhibitory *effects* of on BMP-2 induced Runx2 and [osteocalcin] expression were reversed by SAPK/JNK inhibition regardless of the presence of estradiol . Regulation BGN CTGF 15313168 1285342 Differential *regulation* of [biglycan] and decorin synthesis by in cultured vascular endothelial cells . Regulation BGN IL1B 9689917 522948 In contrast , had a weak inhibitory *effect* on both decorin and [biglycan] expression . Regulation BGN TNF 9485085 488223 The combination of IFN gamma and TNF alpha resulted in a potentiation of the inhibitory *effects* of on [biglycan] mRNA levels ( -79 % ) and transcription rate of the biglycan core protein gene ( -46 % ) . Regulation BHLHE40 CCND1 21506129 2439206 Basic helix-loop-helix transcription factor [DEC1] negatively *regulates* . Regulation BIRC2 EGLN3 23732909 2811907 does not *affect* the protein levels of [cIAP1] or its E2 ubiquitin conjugating enzymes UbcH5 and Ubc13 . Regulation BIRC2 SLC38A3 17704804 1866006 Under these conditions of blocked IEX-1 expression , the NF-kappaB activity remained unaffected by G17 , in particular in Colo320wt cells co-treated with TNFalpha and also the suppressive *effect* of on [cIAP1] and cIAP2 expression was not observed anymore if IEX-1 expression was blocked . Regulation BIRC2 TNF 11473640 841719 In *response* to , expression of [c-IAP1] and c-IAP2 was induced in HeLa cells and ECV304 endothelial cells , but not in mesangial cells . Regulation BIRC2 TNF 15223828 1264861 [c-IAP1] expression was not *affected* by or mutant I kappa B , and mutant I kappa B abolished TNF-alpha induced c-FLIP induction in RPE cells . Regulation BIRC2 TNF 23250032 2737204 *regulation* of [Birc] genes was studied by mRNA expression and promoter analysis . Regulation BIRC3 SLC38A3 17704804 1866007 Under these conditions of blocked IEX-1 expression , the NF-kappaB activity remained unaffected by G17 , in particular in Colo320wt cells co-treated with TNFalpha and also the suppressive *effect* of on cIAP1 and [cIAP2] expression was not observed anymore if IEX-1 expression was blocked . Regulation BIRC3 TNF 11473640 841720 In *response* to , expression of c-IAP1 and [c-IAP2] was induced in HeLa cells and ECV304 endothelial cells , but not in mesangial cells . Regulation BIRC3 TNF 20547836 2284900 Smac mimetics target cancer cells in a *dependent* manner , partly via proteasome degradation of cellular inhibitor of apoptosis 1 ( cIAP1 ) and [cIAP2] . Regulation BIRC3 TNF 23250032 2737205 *regulation* of [Birc] genes was studied by mRNA expression and promoter analysis . Regulation BIRC5 TNF 23250032 2737206 *regulation* of [Birc] genes was studied by mRNA expression and promoter analysis . Regulation BIRC6 TNF 23250032 2737201 *regulation* of [Birc] genes was studied by mRNA expression and promoter analysis . Regulation BIRC7 TNF 23250032 2737202 *regulation* of [Birc] genes was studied by mRNA expression and promoter analysis . Regulation BIRC8 TNF 23250032 2737203 *regulation* of [Birc] genes was studied by mRNA expression and promoter analysis . Regulation BLVRB TNF 9048612 416825 Neither nor IL-6 *affected* the [GHR/GHBP] gene expression . Regulation BMF MAP2K6 22258404 2544904 In this study , we show that [Bmf] is *regulated* at the post-translational level by mutant signaling . Regulation BMI1 ID1 20697353 2335481 In this study , we examined the effect of Id1 on polycomb group ( PcG ) proteins , which are crucial epigenetic gene silencers , and found that *regulated* the expression of Mel-18 and [Bmi-1] , both of which belong to polycomb repressive complex 1 . Regulation BMI1 ID1 24572994 2924800 and NF-?B *regulate* the expression of CD133 and [BMI-1] in an additive or synergistic manner in OSCC , which is associated with the generation of naïve and self-renewable keratinocytes and initiate the growth of xenograft tumors in vivo . Regulation BMP1 EDN2 16300798 1532492 Transcriptional *regulation* of vascular [bone morphogenetic protein] by receptors in early autoimmune diabetes mellitus . Regulation BMP1 HES2 16616763 1598283 This study was designed to explore the *effects* of 130/0.4 on [pulmonary capillary permeability (PCP)] , production of cytokines , and activation of transcription factor in septic rats induced by cecal ligation and puncture (CLP) . Regulation BMP1 ID1 17374642 1720672 These findings suggest that Twist-1 can act as an inhibitor of BMP signaling , and can *regulate* [BMP] signaling through a positive feedback loop repressing Twist-1 function . Regulation BMP1 IL1B 19116903 2025012 The *effect* of on [BMP] receptors was studied by reverse transcription-polymerase chain reaction and flow cytometry . Regulation BMP1 MSX1 9846381 553874 BMPs may in some cases trigger the cell death cascade , while gene products *regulate* [Bmp] expression . Regulation BMP1 OSR1 22791896 2634601 Our data suggest that normally repress bmp4 expression in the lpm , and that [BMP] signaling negatively *regulates* the wnt2b domain . Regulation BMP1 PLAU 11592634 869703 To gain a better insight into the *role* of in Pneumocystis carinii ( P. carinii ) pneumonia ( [PCP] ) , we evaluated PA production in alveolar macrophages ( AMs ) obtained from rats with steroid induced PCP . Regulation BMP1 TNF 16728240 1565628 In this study , we examined the *effects* of on [Bone morphogenetic protein] ( BMP-2 ) , Smads ( which play intracellular signaling of BMPs ) expression and alkaline phosphatase (ALP) activity of human dental pulp ( HDP ) cells to clarify the mechanism of tertiary dentin formation . Regulation BMP1 TNF 16797218 1579055 Bone morphogenetic protein receptors and [bone morphogenetic protein] signaling are *controlled* by in human bone cells . Regulation BMP1 TP63 19717565 2152070 Here we report a previously uncovered *role* of in controlling [bone morphogenetic protein (BMP)] signaling , which is required for maintaining low expression levels of several non-epidermal genes . Regulation BMP1 ZIC2 17329368 1706752 The member , odd paired , *regulates* the Drosophila [BMP] , decapentaplegic , during adult head development . Regulation BMP10 EDN2 16300798 1532516 Transcriptional *regulation* of vascular [bone morphogenetic protein] by receptors in early autoimmune diabetes mellitus . Regulation BMP10 ID1 17374642 1720680 These findings suggest that Twist-1 can act as an inhibitor of BMP signaling , and can *regulate* [BMP] signaling through a positive feedback loop repressing Twist-1 function . Regulation BMP10 IL1B 19116903 2025020 The *effect* of on [BMP] receptors was studied by reverse transcription-polymerase chain reaction and flow cytometry . Regulation BMP10 MSX1 9846381 553890 BMPs may in some cases trigger the cell death cascade , while gene products *regulate* [Bmp] expression . Regulation BMP10 OSR1 22791896 2634635 Our data suggest that normally repress bmp4 expression in the lpm , and that [BMP] signaling negatively *regulates* the wnt2b domain . Regulation BMP10 TNF 16728240 1565637 In this study , we examined the *effects* of on [Bone morphogenetic protein] ( BMP-2 ) , Smads ( which play intracellular signaling of BMPs ) expression and alkaline phosphatase (ALP) activity of human dental pulp ( HDP ) cells to clarify the mechanism of tertiary dentin formation . Regulation BMP10 TNF 16797218 1579072 Bone morphogenetic protein receptors and [bone morphogenetic protein] signaling are *controlled* by in human bone cells . Regulation BMP10 TP63 19717565 2152078 Here we report a previously uncovered *role* of in controlling [bone morphogenetic protein (BMP)] signaling , which is required for maintaining low expression levels of several non-epidermal genes . Regulation BMP10 ZIC2 17329368 1706792 The member , odd paired , *regulates* the Drosophila [BMP] , decapentaplegic , during adult head development . Regulation BMP15 EDN2 16300798 1532495 Transcriptional *regulation* of vascular [bone morphogenetic protein] by receptors in early autoimmune diabetes mellitus . Regulation BMP15 ID1 17374642 1720673 These findings suggest that Twist-1 can act as an inhibitor of BMP signaling , and can *regulate* [BMP] signaling through a positive feedback loop repressing Twist-1 function . Regulation BMP15 IL1B 19116903 2025013 The *effect* of on [BMP] receptors was studied by reverse transcription-polymerase chain reaction and flow cytometry . Regulation BMP15 MSX1 9846381 553876 BMPs may in some cases trigger the cell death cascade , while gene products *regulate* [Bmp] expression . Regulation BMP15 OSR1 22791896 2634603 Our data suggest that normally repress bmp4 expression in the lpm , and that [BMP] signaling negatively *regulates* the wnt2b domain . Regulation BMP15 TNF 16728240 1565629 In this study , we examined the *effects* of on [Bone morphogenetic protein] ( BMP-2 ) , Smads ( which play intracellular signaling of BMPs ) expression and alkaline phosphatase (ALP) activity of human dental pulp ( HDP ) cells to clarify the mechanism of tertiary dentin formation . Regulation BMP15 TNF 16797218 1579056 Bone morphogenetic protein receptors and [bone morphogenetic protein] signaling are *controlled* by in human bone cells . Regulation BMP15 TP63 19717565 2152071 Here we report a previously uncovered *role* of in controlling [bone morphogenetic protein (BMP)] signaling , which is required for maintaining low expression levels of several non-epidermal genes . Regulation BMP15 ZIC2 17329368 1706757 The member , odd paired , *regulates* the Drosophila [BMP] , decapentaplegic , during adult head development . Regulation BMP2 CTGF 24127409 2896537 Collectively , the data from these studies demonstrate that acts to negatively *regulate* [BMP-2] induced signaling and osteoblast differentiation , and warrant additional studies to determine the precise mechanism ( s ) responsible for this effect . Regulation BMP2 EDN2 16300798 1532498 Transcriptional *regulation* of vascular [bone morphogenetic protein] by receptors in early autoimmune diabetes mellitus . Regulation BMP2 EPHB2 10679278 668888 *Involvement* of in [BMP-2] induced osteoblastic differentiation of mesenchymal progenitor cell line C3H10T1/2 . Regulation BMP2 EPHB2 10679278 668892 These results indicate that is *involved* in [BMP-2] induced osteoblast differentiation . Regulation BMP2 ID1 17374642 1720674 These findings suggest that Twist-1 can act as an inhibitor of BMP signaling , and can *regulate* [BMP] signaling through a positive feedback loop repressing Twist-1 function . Regulation BMP2 IL1B 16805677 1579599 *Effect* of on transforming growth factor-beta and [bone morphogenetic protein-2] expression in human periodontal ligament and alveolar bone cells in culture : modulation by avocado and soybean unsaponifiables . Regulation BMP2 IL1B 19116903 2025014 The *effect* of on [BMP] receptors was studied by reverse transcription-polymerase chain reaction and flow cytometry . Regulation BMP2 MMP28 20665818 2298244 The aim of this study is to investigate whether [BMP-2] *regulates* the oral sulcus formation of mouse embryonic tongue by modifying the expression of TIMP and . Regulation BMP2 MMP7 20665818 2298259 The aim of this study is to investigate whether [BMP-2] *regulates* the oral sulcus formation of mouse embryonic tongue by modifying the expression of TIMP and . Regulation BMP2 MSX1 9846381 553878 BMPs may in some cases trigger the cell death cascade , while gene products *regulate* [Bmp] expression . Regulation BMP2 NT5E 18980528 1983320 We examined how *regulates* the mRNA expression of bone/cementum related proteins ( alkaline phosphatase [ ALPase ] , osteopontin [ OPN ] , osteocalcin [ OC ] , and bone morphogenetic protein [ [BMP]-2] ) in cultures of HPL cells . Regulation BMP2 OSR1 22791896 2634605 Our data suggest that normally repress bmp4 expression in the lpm , and that [BMP] signaling negatively *regulates* the wnt2b domain . Regulation BMP2 TNF 15219845 1264470 The *effects* of ox-LDL , but not , on MGP and [BMP2] expression were inhibited by pretreatment of cells with an antibody directed at LOX-1 , a lectin-like receptor for ox-LDL ( 10 microg/mL ) . Regulation BMP2 TNF 16728240 1565630 In this study , we examined the *effects* of on [Bone morphogenetic protein] ( BMP-2 ) , Smads ( which play intracellular signaling of BMPs ) expression and alkaline phosphatase (ALP) activity of human dental pulp ( HDP ) cells to clarify the mechanism of tertiary dentin formation . Regulation BMP2 TNF 16797218 1579057 Bone morphogenetic protein receptors and [bone morphogenetic protein] signaling are *controlled* by in human bone cells . Regulation BMP2 TNF 9213003 441524 The modulatory *effects* of interleukin (IL)-1 beta and on [bone morphogenetic protein (BMP)-2-] and -4-induced alkaline phosphatase (ALP) activity were examined in cultures of mouse MC3T3-E1 osteoblastic cells . Regulation BMP2 TP63 19717565 2152072 Here we report a previously uncovered *role* of in controlling [bone morphogenetic protein (BMP)] signaling , which is required for maintaining low expression levels of several non-epidermal genes . Regulation BMP2 ZIC2 17329368 1706762 The member , odd paired , *regulates* the Drosophila [BMP] , decapentaplegic , during adult head development . Regulation BMP3 EDN2 16300798 1532501 Transcriptional *regulation* of vascular [bone morphogenetic protein] by receptors in early autoimmune diabetes mellitus . Regulation BMP3 ID1 17374642 1720675 These findings suggest that Twist-1 can act as an inhibitor of BMP signaling , and can *regulate* [BMP] signaling through a positive feedback loop repressing Twist-1 function . Regulation BMP3 IL1B 19116903 2025015 The *effect* of on [BMP] receptors was studied by reverse transcription-polymerase chain reaction and flow cytometry . Regulation BMP3 MSX1 9846381 553880 BMPs may in some cases trigger the cell death cascade , while gene products *regulate* [Bmp] expression . Regulation BMP3 OSR1 22791896 2634607 Our data suggest that normally repress bmp4 expression in the lpm , and that [BMP] signaling negatively *regulates* the wnt2b domain . Regulation BMP3 TNF 16728240 1565631 In this study , we examined the *effects* of on [Bone morphogenetic protein] ( BMP-2 ) , Smads ( which play intracellular signaling of BMPs ) expression and alkaline phosphatase (ALP) activity of human dental pulp ( HDP ) cells to clarify the mechanism of tertiary dentin formation . Regulation BMP3 TNF 16797218 1579058 Bone morphogenetic protein receptors and [bone morphogenetic protein] signaling are *controlled* by in human bone cells . Regulation BMP3 TP63 19717565 2152073 Here we report a previously uncovered *role* of in controlling [bone morphogenetic protein (BMP)] signaling , which is required for maintaining low expression levels of several non-epidermal genes . Regulation BMP3 ZIC2 17329368 1706767 The member , odd paired , *regulates* the Drosophila [BMP] , decapentaplegic , during adult head development . Regulation BMP4 EDN2 16300798 1532504 Transcriptional *regulation* of vascular [bone morphogenetic protein] by receptors in early autoimmune diabetes mellitus . Regulation BMP4 ID1 17374642 1720676 These findings suggest that Twist-1 can act as an inhibitor of BMP signaling , and can *regulate* [BMP] signaling through a positive feedback loop repressing Twist-1 function . Regulation BMP4 IL1B 19116903 2025016 The *effect* of on [BMP] receptors was studied by reverse transcription-polymerase chain reaction and flow cytometry . Regulation BMP4 MSX1 12944425 1135874 We also provide evidence that endogenous [Bmp4] expression is *regulated* by the combined activity of and Msx2 in the forming digit tip ; Regulation BMP4 MSX1 23720046 2796830 and Tbx2 antagonistically *regulate* [Bmp4] expression during the bud-to-cap stage transition in tooth development . Regulation BMP4 MSX1 9846381 553882 BMPs may in some cases trigger the cell death cascade , while gene products *regulate* [Bmp] expression . Regulation BMP4 OSR1 22791896 2634618 Our data suggest that normally repress bmp4 expression in the lpm , and that [BMP] signaling negatively *regulates* the wnt2b domain . Regulation BMP4 TNF 16728240 1565632 In this study , we examined the *effects* of on [Bone morphogenetic protein] ( BMP-2 ) , Smads ( which play intracellular signaling of BMPs ) expression and alkaline phosphatase (ALP) activity of human dental pulp ( HDP ) cells to clarify the mechanism of tertiary dentin formation . Regulation BMP4 TNF 16797218 1579059 Bone morphogenetic protein receptors and [bone morphogenetic protein] signaling are *controlled* by in human bone cells . Regulation BMP4 TNF 21411747 2447985 Transcriptional *regulation* of [bone morphogenetic protein 4] by and its relationship with age related macular degeneration . Regulation BMP4 TP63 19717565 2152074 Here we report a previously uncovered *role* of in controlling [bone morphogenetic protein (BMP)] signaling , which is required for maintaining low expression levels of several non-epidermal genes . Regulation BMP4 ZIC2 17329368 1706772 The member , odd paired , *regulates* the Drosophila [BMP] , decapentaplegic , during adult head development . Regulation BMP5 EDN2 16300798 1532507 Transcriptional *regulation* of vascular [bone morphogenetic protein] by receptors in early autoimmune diabetes mellitus . Regulation BMP5 ID1 17374642 1720677 These findings suggest that Twist-1 can act as an inhibitor of BMP signaling , and can *regulate* [BMP] signaling through a positive feedback loop repressing Twist-1 function . Regulation BMP5 IL1B 19116903 2025017 The *effect* of on [BMP] receptors was studied by reverse transcription-polymerase chain reaction and flow cytometry . Regulation BMP5 MSX1 9846381 553884 BMPs may in some cases trigger the cell death cascade , while gene products *regulate* [Bmp] expression . Regulation BMP5 OSR1 22791896 2634620 Our data suggest that normally repress bmp4 expression in the lpm , and that [BMP] signaling negatively *regulates* the wnt2b domain . Regulation BMP5 TNF 16728240 1565633 In this study , we examined the *effects* of on [Bone morphogenetic protein] ( BMP-2 ) , Smads ( which play intracellular signaling of BMPs ) expression and alkaline phosphatase (ALP) activity of human dental pulp ( HDP ) cells to clarify the mechanism of tertiary dentin formation . Regulation BMP5 TNF 16797218 1579060 Bone morphogenetic protein receptors and [bone morphogenetic protein] signaling are *controlled* by in human bone cells . Regulation BMP5 TP63 19717565 2152075 Here we report a previously uncovered *role* of in controlling [bone morphogenetic protein (BMP)] signaling , which is required for maintaining low expression levels of several non-epidermal genes . Regulation BMP5 ZIC2 17329368 1706777 The member , odd paired , *regulates* the Drosophila [BMP] , decapentaplegic , during adult head development . Regulation BMP6 EDN2 16300798 1532510 Transcriptional *regulation* of vascular [bone morphogenetic protein] by receptors in early autoimmune diabetes mellitus . Regulation BMP6 ID1 17374642 1720678 These findings suggest that Twist-1 can act as an inhibitor of BMP signaling , and can *regulate* [BMP] signaling through a positive feedback loop repressing Twist-1 function . Regulation BMP6 IL1B 19116903 2025018 The *effect* of on [BMP] receptors was studied by reverse transcription-polymerase chain reaction and flow cytometry . Regulation BMP6 MSX1 9846381 553886 BMPs may in some cases trigger the cell death cascade , while gene products *regulate* [Bmp] expression . Regulation BMP6 OSR1 22791896 2634622 Our data suggest that normally repress bmp4 expression in the lpm , and that [BMP] signaling negatively *regulates* the wnt2b domain . Regulation BMP6 TNF 16728240 1565634 In this study , we examined the *effects* of on [Bone morphogenetic protein] ( BMP-2 ) , Smads ( which play intracellular signaling of BMPs ) expression and alkaline phosphatase (ALP) activity of human dental pulp ( HDP ) cells to clarify the mechanism of tertiary dentin formation . Regulation BMP6 TNF 16797218 1579061 Bone morphogenetic protein receptors and [bone morphogenetic protein] signaling are *controlled* by in human bone cells . Regulation BMP6 TP63 19717565 2152076 Here we report a previously uncovered *role* of in controlling [bone morphogenetic protein (BMP)] signaling , which is required for maintaining low expression levels of several non-epidermal genes . Regulation BMP6 ZIC2 17329368 1706782 The member , odd paired , *regulates* the Drosophila [BMP] , decapentaplegic , during adult head development . Regulation BMP7 EDN2 16300798 1532513 Transcriptional *regulation* of vascular [bone morphogenetic protein] by receptors in early autoimmune diabetes mellitus . Regulation BMP7 ID1 17374642 1720679 These findings suggest that Twist-1 can act as an inhibitor of BMP signaling , and can *regulate* [BMP] signaling through a positive feedback loop repressing Twist-1 function . Regulation BMP7 IL1B 12233782 988752 To elucidate the *effects* of on [osteogenic protein-1 (OP-1)] gene expression in a polylayer culture of rabbit articular chondrocytes , we measured rabbit OP-1 mRNA using quantitative TaqMan reverse transcriptase-polymerase chain reaction ( RT-PCR ) techniques . Regulation BMP7 IL1B 19116903 2025010 *Effect* of on [osteogenic protein 1-induced] signaling in adult human articular chondrocytes . Regulation BMP7 IL1B 19116903 2025011 Two major receptor activated Smad (R-Smad) signaling pathways , bone morphogenetic protein (BMP) and MAPK , were examined in a model of interleukin-1beta (IL-1beta) induced cartilage degeneration to investigate the *effect* of on [osteogenic protein 1 (OP-1)] signaling in adult human articular chondrocytes . Regulation BMP7 IL1B 19116903 2025019 The *effect* of on [BMP] receptors was studied by reverse transcription-polymerase chain reaction and flow cytometry . Regulation BMP7 MSX1 9846381 553888 BMPs may in some cases trigger the cell death cascade , while gene products *regulate* [Bmp] expression . Regulation BMP7 OSR1 22791896 2634624 Our data suggest that normally repress bmp4 expression in the lpm , and that [BMP] signaling negatively *regulates* the wnt2b domain . Regulation BMP7 TNF 16728240 1565635 In this study , we examined the *effects* of on [Bone morphogenetic protein] ( BMP-2 ) , Smads ( which play intracellular signaling of BMPs ) expression and alkaline phosphatase (ALP) activity of human dental pulp ( HDP ) cells to clarify the mechanism of tertiary dentin formation . Regulation BMP7 TNF 16797218 1579062 Bone morphogenetic protein receptors and [bone morphogenetic protein] signaling are *controlled* by in human bone cells . Regulation BMP7 TP63 19717565 2152077 Here we report a previously uncovered *role* of in controlling [bone morphogenetic protein (BMP)] signaling , which is required for maintaining low expression levels of several non-epidermal genes . Regulation BMP7 ZIC2 17329368 1706787 The member , odd paired , *regulates* the Drosophila [BMP] , decapentaplegic , during adult head development . Regulation BMX TNF 14532277 1174866 In *response* to , [Etk] and VEGFR2 form a complex resulting in a reciprocal activation between the two kinases . Regulation BNC1 IL1B 1322806 192308 Accordingly , we investigated the *effects* of recombinant human interleukin-1 alpha (IL-1 alpha) , recombinant human , and recombinant human tumor necrosis factor alpha (TNF alpha) on [bovine nasal chondrocyte (BNC)] responsiveness . Regulation BNC1 TNF 1322806 192306 Accordingly , we investigated the *effects* of recombinant human interleukin-1 alpha (IL-1 alpha) , recombinant human interleukin-1 beta (IL-1 beta) , and recombinant human on [bovine nasal chondrocyte (BNC)] responsiveness . Regulation BNIP3 CDKN1C 22705236 2633867 Indeed , the expression of Bax , Noxa , PUMA , [BNIP(3)] , and cleaved caspase-3 was not *affected* by induction . Regulation BOC ZIC2 23678105 2785445 Analyses of the molecular and cellular consequences of introducing Shh into the developing VTC and Zic2 and Boc into the central retina indicate that [Boc] expression alone is insufficient to fully activate the ipsilateral program and that *regulates* Shh expression . Regulation BPI AHRR 19930850 2167313 This prospective , randomized controlled study evaluated the *effects* of on the expression of plasma interferon-inducible protein-10 (IP-10) and bactericidal/permeability increasing protein ( [BPI] ) in patients undergoing elective total hip replacement . Regulation BPI CEBPE 17483073 1738832 In this study , we studied the *role* of a myeloid-specific transcription factor , ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Regulation BPI NPTX1 8040321 266670 [BPI] and p15A display similar features of antibacterial action distinct from defensin NP-1 , but *acts* synergistically only with BPI and not with p15A . Regulation BPI SP1 16282362 1518466 Studies of BPI promoter expression in IECs identified regulatory regions of the BPI promoter and revealed a prominent *role* for CCAAT/enhancer binding protein and especially in the basal regulation of [BPI] . Regulation BPI SP3 16282362 1518467 Studies of BPI promoter expression in IECs identified regulatory regions of the BPI promoter and revealed a prominent *role* for CCAAT/enhancer binding protein and especially in the basal regulation of [BPI] . Regulation BPI TCF12 17483073 1738824 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Regulation BPI TCF15 17483073 1738825 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Regulation BPI TCF19 17483073 1738826 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Regulation BPI TCF20 17483073 1738827 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Regulation BPI TCF21 17483073 1738828 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Regulation BPI TCF23 17483073 1738833 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Regulation BPI TCF24 17483073 1738835 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Regulation BPI TCF25 17483073 1738834 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Regulation BPI TCF3 17483073 1738829 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Regulation BPI TCF4 17483073 1738830 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Regulation BPI TCF7 17483073 1738831 In this study , we studied the *role* of a myeloid-specific , CCAAT/enhancer binding protein epsilon ( C/EBP epsilon ) , in the regulation of [BPI] gene expression . Regulation BPI TNF 8648149 363680 To assess the *role* of in the elevated [BPI] levels during sepsis , the following studies were performed . Regulation BRSK2 STK39 23907667 2861504 [BRSK2] ( also known as SAD-A ) , a of the AMP activated protein kinase family *affected* VCP/p97 activity in ERAD . Regulation BSG MMP28 19003972 2016333 In summary the data argue against a causal *role* for [EMMPRIN] for the induction of gene expression during adult mammary gland development . Regulation BSG MMP28 21228176 2379588 Together , our results are the first to emphasize a role for EMMPRIN in MS and EAE , whereby [EMMPRIN] *regulates* leukocyte trafficking through increasing activity . Regulation BSG MMP7 19003972 2016348 In summary the data argue against a causal *role* for [EMMPRIN] for the induction of gene expression during adult mammary gland development . Regulation BSG MMP7 21228176 2379603 Together , our results are the first to emphasize a role for EMMPRIN in MS and EAE , whereby [EMMPRIN] *regulates* leukocyte trafficking through increasing activity . Regulation BST2 TNF 23401591 2748651 IFN-? , IL-4 , IL-10 , and had only marginal *effects* on [BST2] expression in blood leukocytes compared with TLR9L . Regulation BTG1 ARSA 2949396 66702 We studied the *effect* of versus placebo on [B-thromboglobulin (B-TG)] and platelet factor 4 (PF4) plasma levels and ADP induced platelet aggregation in 25 male patients with transient ischaemic attacks ( TIA ) . Regulation BTG2 ARSA 2949396 66703 We studied the *effect* of versus placebo on [B-thromboglobulin (B-TG)] and platelet factor 4 (PF4) plasma levels and ADP induced platelet aggregation in 25 male patients with transient ischaemic attacks ( TIA ) . Regulation BTG3 ARSA 2949396 66704 We studied the *effect* of versus placebo on [B-thromboglobulin (B-TG)] and platelet factor 4 (PF4) plasma levels and ADP induced platelet aggregation in 25 male patients with transient ischaemic attacks ( TIA ) . Regulation BTG4 ARSA 2949396 66705 We studied the *effect* of versus placebo on [B-thromboglobulin (B-TG)] and platelet factor 4 (PF4) plasma levels and ADP induced platelet aggregation in 25 male patients with transient ischaemic attacks ( TIA ) . Regulation BTRC IL1B 16407046 1513307 We investigated whether HDSMCs are capable of expressing and releasing MCP-1 , IL-6 and [SCF] in *response* to IL-4 , IL-13 , and tumor necrosis factor-alpha . Regulation BTRC IL1B 16584593 1544093 there were not *effects* of expression on expressions of IL-6 and [SCF] . Regulation BTRC TNF 10067879 594039 Activin , TGF beta , TGF alpha , and had no *effect* on [SCF] gene expression in vitro . Regulation BTRC TNF 16407046 1513306 We investigated whether HDSMCs are capable of expressing and releasing MCP-1 , IL-6 and [SCF] in *response* to IL-4 , IL-13 , IL-1beta and . Regulation BTRC TNF 23662587 2805505 Comparison of the stimulatory *effects* of interleukin (IL)-1a or on [SCF] production between SK cells and NHK demonstrated that SK cells do not respond to IL-1a or TNF-a to stimulate production of SCF , whereas a significant stimulation of SCF is elicited by those same cytokines in NHK . Regulation BUB1 STK39 18083840 1837482 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation C10orf10 FOXO1 21510935 2439348 *regulates* expression of [decidual protein induced by progesterone] ( DEPP ) in human endothelial cells . Regulation C1QA TNF 9407058 470728 The capacity to bind [C1q] , mediated by the pentraxin domain , is consistent with the view that PTX3 , produced in tissues by endothelial cells or macrophages in *response* to interleukin-1 and , may act as a local regulator of innate immunity . Regulation C1QB TNF 9407058 470756 The capacity to bind [C1q] , mediated by the pentraxin domain , is consistent with the view that PTX3 , produced in tissues by endothelial cells or macrophages in *response* to interleukin-1 and , may act as a local regulator of innate immunity . Regulation C1QBP TNF 10188109 603082 These results indicated that TGF-beta and upregulate the mRNA levels for cC1q-R and collagen and that they do not *affect* [gC1q-R] mRNA levels significantly . Regulation C1QTNF9 TNF 23212557 2718451 The inhibitory *effect* of on PPAR? and [CTRP9] was reversed by Tiron or rosiglitazone . Regulation C2 FUT4 2019419 157145 We examined the inhibitory *effect* of on the [C3/C5 convertase] activity of the cobra venom factor derived enzyme CVF , Bb by measuring C5b6 mediated reactive lysis of unsensitized guinea pig erythrocytes and by measuring directly the released fragments C3-des-Arg and C5a-des-Arg . Regulation C22orf29 MAP2K6 17624732 1775076 We have previously shown Bim , a [BH3-only protein] of the Bcl-2 family , to be phosphorylated in mitosis , in a *dependent* manner ( M. Grãos , A. D. Almeida , S. Chatterjee , Biochem . Regulation C3 CTGF 22340339 2520829 The aim of this study was to investigate whether C3a , C5a can regulate TEMT by transforming growth factor-ß1 ( TGF-ß ) signaling pathway and the *effects* of C3a and C5a receptor antagonists ( C3aRA and C5aRA ) on [C3a-] and C5a induced TEMT . Regulation C3 IL1B 8887027 391387 The present findings indicate that intestinal epithelial cells are indeed capable of synthesizing [complement C3] in *response* to and TGF-beta . Regulation C3 IL1B 9403532 469602 [Complement C3] production in human intestinal epithelial cells is *regulated* by and tumor necrosis factor alpha . Regulation C4A FUT4 2303313 127821 The *effect* of ( Nafamstat Mesilate ) on C3a , [C4a] and C5a generation in vitro and inflammatory reactions in vivo . Regulation C5 FUT4 2303313 127832 The *effect* of ( Nafamstat Mesilate ) on C3a , C4a and [C5a] generation in vitro and inflammatory reactions in vivo . Regulation C5 SELL 1279509 202989 Eosinophil expression of decreased modestly after stimulation with platelet activating factor , but was minimally *affected* by N-formyl-methionyl-leucyl-phenylalanine , leukotriene B4 , or [C5a] compared with their effects on neutrophils . Regulation C5 TNF 10996218 733815 Intracerebral [complement C5a] receptor ( CD88 ) expression is *regulated* by and lymphotoxin-alpha following closed head injury in mice . Regulation C5AR1 TNF 10996218 733819 These data show that the posttraumatic neuronal expression of the [C5aR] is , at least in part , *regulated* by and lymphotoxin-alpha at 7 days after trauma . Regulation C9orf3 TNF 7635986 317373 Cytokines , including TNF alpha , have been identified in human lesions , therefore , we undertook a series of studies to evaluate the *effect* of on monocyte/macrophage [apo] E production . Regulation CA1 ITGB2 10551644 565256 Antibody mediated inhibition of proliferation failed to impair the ability of T cells to subsequently proliferate in response to stimulation by the original or third party alloantigen or mobilize [ [Ca++]i] in *response* to CD3 or receptor ligation . Regulation CA12 C12orf57 12606647 1079758 In this study , we investigated the *effects* of and lauric acid ( C12 ) on [Ca(i)2+] in WD primary HAE cells and determined whether these effects were necessary for the acute MCFA induced reduction in transepithelial resistance ( R ( T ) ) and increased permeability . Regulation CA12 CA3 9661255 518120 The results suggest the plasticity of the beta 1 mRNA in [CA1-2] as well as differential *involvement* of CA1-2 and in response to the pentobarbital perturbation . Regulation CA12 CALCA 3936046 55197 The *effect* of and parathyroid hormone (PTH) on [carbonic anhydrase] ( carbonate hydrolyase , EC 4.2.1.1. ) activity was tested in human erythrocyte hemolysates and with purified carbonic anhydrases I and II . Regulation CA12 CALCA 7926626 273608 The *effect* of human gene related peptide ( hCGRP ) on [carbonic anhydrase] activity in trout branchial membranes was investigated . Regulation CA12 EGF 12127808 966182 Here we examined the *effects* of on bicarbonate production and [carbonic anhydrase (CA)] activity in a PDC explant model . Regulation CA12 ELF1 21591890 2430689 In this work , the *effect* of on bovine lung membrane [carbonic anhydrase (CA)] were studied . Regulation CA12 ELF2 21591890 2430690 In this work , the *effect* of on bovine lung membrane [carbonic anhydrase (CA)] were studied . Regulation CA12 ELF3 21591890 2430691 In this work , the *effect* of on bovine lung membrane [carbonic anhydrase (CA)] were studied . Regulation CA12 ELF4 21591890 2430692 In this work , the *effect* of on bovine lung membrane [carbonic anhydrase (CA)] were studied . Regulation CA12 ELF5 21591890 2430693 In this work , the *effect* of on bovine lung membrane [carbonic anhydrase (CA)] were studied . Regulation CA12 ESR1 18451179 1902922 *regulation* of [carbonic anhydrase XII] through a distal enhancer in breast cancer . Regulation CA12 FLOT2 16788042 1577594 [Carbonic anhydrase (CA)] activity and relative expression of CA mRNA were measured in the gills of the euryhaline green crab Carcinus maenas in *response* to , injection of eyestalk extract and exposure to low salinity . Regulation CA12 IAPP 7926626 273634 Rat that has a 43 % homology with hCGRP had no *effect* on [carbonic anhydrase] activity . Regulation CA12 MT-CO2 11985719 938337 Cyanobacteria possess light dependent uptake activity that results in the net hydration of CO2 to HCO3- and may *involve* a protein mediated [carbonic anhydrase (CA)-like] activity . Regulation CA12 MT-CO2 16169965 1467538 Regulation of the expression of intracellular [beta-carbonic anhydrase] in *response* to and light in the marine diatom Phaeodactylum tricornutum . Regulation CA12 MT-CO2 23314813 2746657 Elevated levels *affect* the activity of nitrate reductase and [carbonic anhydrase] in the calcifying rhodophyte Corallina officinalis . Regulation CA12 MT-CO2 8330192 223548 The results support a role for [carbonic anhydrase] in trigeminal *responses* to . Regulation CA12 ODC1 11351322 814799 Early [carbonic anhydrase] induction in the gills of the blue crab , Callinectes sapidus , during low salinity acclimation is *independent* of activity . Regulation CA12 PTH 233968 931 Therefore , a possible inhibitory *effect* of on [carbonic anhydrase] was evaluated in the homogenate of rat renal cortex by an indicator titration method . Regulation CA12 PTH 233968 1464 The inhibitory *effect* of on [carbonic anhydrase] was specific to renal cortex . Regulation CA12 PTH 3936046 55198 The *effect* of calcitonin (CT) and on [carbonic anhydrase] ( carbonate hydrolyase , EC 4.2.1.1. ) activity was tested in human erythrocyte hemolysates and with purified carbonic anhydrases I and II . Regulation CA12 S100A12 16797782 1631712 The physiological significance of calcitonin gene related peptide (CGRP) during biomineralization was investigated by assessing the *effect* of human on the [carbonic anhydrase] activity in gill membranes of the pearl oyster , Pinctada margaritifera . Regulation CA12 SETD2 19291313 2055993 We examined expression of CAIX , CAXII and HIF-1alpha in the developing human fetus and postnatal tissues to determine whether expression of CAIX and [CAXII] is exclusively *regulated* by . Regulation CA2 ARSA 1807005 177141 An inhibitor against prostaglandin synthesis , acetylsalicylic acid ( ASA , 10 ( -6 ) M ) abolished BK-induced 6-keto-PGF1 alpha synthesis , whereas did not *affect* the increase in [ [Ca2+] ] i. BK-induced increases in [ Ca2+ ] i and 6-keto-PGF1 alpha production occurred in a dose dependent manner and the half-maximal response was observed at the same concentration of BK ( 10 ( -7 ) M ) . Regulation CA2 CABP4 10569182 567958 Expression of regucalcin and microsomal [Ca2+-ATPase] *regulation* in rat brain : attenuation with increasing age . Regulation CA2 CABP4 10569182 567976 The expression of regucalcin and its *effect* on the microsomal [Ca2+-ATPase] activity in rat brain tissues was investigated . Regulation CA2 CABP4 18003854 1827185 These findings demonstrate how light stimulated changes in phosphorylation and Ca2+ binding may *regulate* presynaptic [Ca2+] signals in photoreceptors . Regulation CA2 CAPN8 17497432 1739764 *Regulation* of plasma membrane [Ca2+-ATPase] in human platelets by . Regulation CA2 CD14 12805475 1120589 Inclusion of TNF-alpha in culture media of Kupffer cells enhanced expression , LPS induced intracellular [Ca2+] concentration *response* , and production of TNF-alpha . Regulation CA2 CEACAM6 20946877 2343638 Importantly , did not *affect* diastolic [Ca2+] or SR Ca2+ content , as assessed by rapid caffeine application . Regulation CA2 EDN2 10455291 638657 The *effects* of endothelin (ET)-1 ( 1-31 ) and ( 1-31 ) , human chymase products of the corresponding big ETs , on the intracellular free [Ca2+ concentration ([Ca2+]i)] and [ 125I ] -ET-1 binding were investigated using human cultured bronchial smooth muscle cells ( BSMC ) . Regulation CA2 EDN2 1311519 178849 We examined the *effects* of on both the trichloroacetic acid precipitable 3H-labeled glycoconjugate release and intracellular [Ca2+ concentration ([Ca2+]i])] measured by the usage of fura-2 in submucosal glands isolated from feline trachea . Regulation CA2 EDN2 1323435 192411 In addition , pretreatment with 10 microM of the Na ( + ) -H+ exchange inhibitor 5- ( N-methyl-N-isobutyl ) -amiloride significantly attenuated induced *effects* on the intracellular [Ca2+] transient and contraction during acidosis . Regulation CA2 EDN2 1333979 205803 *Effects* of on cytosolic [Ca2+] level and mechanical activity in rat uterine smooth muscle . Regulation CA2 EDN2 1333979 205806 The *effects* of on cytosolic [Ca2+] level ( [ Ca2+ ] i ) and mechanical activity were examined in isolated rat uterine smooth muscle . Regulation CA2 EDN2 1516644 196797 *Effects* of on intracellular [Ca2+] and contractility in single ventricular myocytes from the ferret and human . Regulation CA2 EDN2 1706144 152995 Preincubation of cells with isoproterenol reduced the peak [Ca2+] *response* to and blocked the sustained elevation . Regulation CA2 EDN2 1849088 153818 We studied the presence of specific binding sites for and the *effect* of ET on cytosolic free [Ca2+ concentration ([Ca2+]i)] in murine thioglycolate activated peritoneal macrophages . Regulation CA2 EDN2 1872870 165218 The *effect* of on the cytosolic-free calcium [ ( [Ca2+] ] i ) changes in polymorphonuclear leukocytes ( PMN ) from normal humans and Wistar rats was investigated . Regulation CA2 EDN2 2154214 127440 The *effects* of three forms of , ET-1 , -2 and -3 , on intracellular free [Ca2+ concentration ([Ca2+]i)] and their receptor binding activities have been compared in murine fibroblast cell line Swiss 3T3 as well as diploid human fibroblast cell line FS-4 . Regulation CA2 EDN2 2541709 110499 We have investigated the *effects* of on phosphoinositide metabolism and [Ca2+] mobilization in cultured A10 cells . Regulation CA2 EDN2 2549995 117483 The *effects* of on cellular [Ca2+] mobilization were examined in cultured rat vascular smooth muscle cells ( VSMC ) . Regulation CA2 EDN2 2556139 122084 The *effects* of and angiotensin II on [[Ca2+i] ] are only additive . Regulation CA2 EDN2 7698185 288132 We investigated the *effects* of on tension development and [Ca2+] responsiveness in both intact and saponin skinned ferret right ventricular papillary muscles . Regulation CA2 EDN2 7775301 308917 Exercise training alters the [Ca2+] and contractile *responses* of coronary arteries to . Regulation CA2 EDN2 8098849 219859 The *effects* of three forms of , ET-1 , -2 and -3 , on intracellular free [Ca2+ concentration ([Ca2+]i)] , their receptor binding activities , and DNA synthesis were investigated in cultured porcine basilar arterial smooth muscle cells . Regulation CA2 EDN2 8764315 374854 We conclude that growth on a collagen type I gel uncouples contractility from a proliferative response in mesangial cells , suppressing proliferation while enhancing contraction and [Ca2+] signaling in *response* to . Regulation CA2 EDN2 8994441 409331 The dissociation between induced contractile and [Ca2+] *responses* of collaterals indicates that the mechanisms involved in increasing Ca2+ sensitivity of contractile proteins during endothelin stimulation may be altered in collateral arteries . Regulation CA2 F2R 12632022 1067926 In summary , [Ca(II)3] ( 3,5-DIPS ) 6 , a new calmodulin dependent nitric oxide synthase activator , decreases P-selectin expression of human platelets in *response* to activation . Regulation CA2 F2R 12716374 1083716 We assessed cytoplasmic [Ca2+] mobilization in *response* to activation with thrombin and ( SFLLRN ) and PAR4 ( GYPGKF ) peptides in two patients whose platelets were deficient in two major signalling proteins , Galphaq or phospholipase ( PLC)-beta2 . Regulation CA2 F2R 16939417 1673111 Desensitization of and PAR-4 or pre-treatment with the PAR-1 and PAR-4 antagonists SCH 79797 and tcY-NH2 reduced Ca2+ mobilization induced by thrombin , and depletion of the DTS after desensitization or blockade of PAR-1 and PAR-4 had no significant *effect* on [Ca2+] release stimulated by thrombin through the GPIb-IX-V receptor . Regulation CA2 F2R 7810595 284971 Moreover , [Ca2+] *response* to the 6-amino acid peptide was independent of external Na+ . Regulation CA2 HRH1 7980641 281375 The enhancement of [Ca2+] *responses* by DTT was reversed by the sulphydryl oxidizing agent dithiobis- ( 2-nitrobenzoic acid ) . Regulation CA2 IL1B 11171124 783852 Therefore , we investigated the *effect* of on bradykinin ( BK ) -induced inositol phosphate [ Ins ( X ) P ] accumulation and [Ca2+] mobilization , and up-regulation of BK receptor density in canine cultured tracheal smooth-muscle cells ( TSMCs ) . Regulation CA2 IL1B 9227535 443307 Involvement of ceramide in inhibitory *effect* of on L-type [Ca2+] current in adult rat ventricular myocytes . Regulation CA2 ITGAL 19542227 2116378 Using membrane vesicles expressing the mouse class I major histocompatibility complex , i.e. Ld plus costimulatory ligands , i.e . B7-1 and intercellular adhesion molecule-1 along with 2C T cell receptor transgenic T cells , we investigated the *roles* of CD28 and ( lymphocyte function associated antigen-1 ) in the activation of PLC-gamma1 and [Ca2+] signaling . Regulation CA2 ITGB2 19542227 2116381 In particular , when the T cells were activated by suboptimal T cell receptor stimulation , *played* an indispensable role in the [Ca2+] signaling . Regulation CA2 ITGB2 19542227 2116384 These results ensure the unique *role* of in T cell [Ca2+] signaling and reveal that LFA-1 dependent Ca2+ entry proceeds via a mechanism separate from store operated Ca2+ entry . Regulation CA2 JAG1 8510321 221717 This study was aimed at determining whether the thrombin (TRB) induced aggregation and intracellular free [Ca2+] ( [ Ca ( 2+ ) ] i ) mobilization of fura-2 loaded human platelets would be *affected* by , i.e. , kanamycin ( KM ) , gentamicin ( GM ) and fradiomycin ( FRM ) with 4 , 5 and 6 amino groups in their molecules , respectively . Regulation CA2 MAP2K6 18034335 1924444 In summary , the activation of TRPV1 by capsaicin modulates the SP release from DRG neurons via two different mechanisms , one requiring extracellular [Ca2+] , the activation of PI3K and the IP3 dependent intracellular Ca2+ release , and the other which is independent of extracellular Ca2+ but *involves* the activation of . Regulation CA2 MAP2K6 8954997 401131 Although inhibitor had no *effect* on oxytocin induced intracellular [Ca2+] mobilization in either pregnant human or pregnant rat uterine cells , it partly inhibited oxytocin induced pregnant rat uterine contraction in a dose dependent manner . Regulation CA2 PLAU 10491182 646285 The intracellular [Ca2+] *response* to was independent of extracellular Ca2+ , was pertussis toxin-sensitive , and was blocked by both thapsigargin and the phospholipase C inhibitor U-73122 . Regulation CA2 PLAU 10491182 646287 The uPA induced increase in intracellular [Ca2+] was *independent* of proteolytic activity . Regulation CA2 RGS2 18398336 1893703 The present study investigates the *effect* of silencing in fibroblasts from six BS/GS patients on intracellular [Ca2+] ( CaI2+ ) mobilization and extracellular signal regulated kinase ( ERK ) 1/2 phosphorylation , established Ang II-mediated responses . Regulation CA2 S100B 11312263 826973 The giant protein AHNAK is a specific target for the calcium- and zinc binding S100B protein : potential implications for [Ca2+] homeostasis *regulation* by . Regulation CA2 S1PR3 18678983 1955255 Taken together , cell-culture changes the mediated [Ca2+] *response* to S1P in rat aortic myocytes . Regulation CA2 S1PR3 9878524 557745 Thus , , whose mRNA expression is downregulated during cell differentiation , may be *responsible* for the S1P induced [Ca2+] response in HL-60 leukemia cells . Regulation CA2 SELL 7518434 261859 The *role* of in ROI production and [Ca2+] signaling in suspended neutrophils was examined using the DREG series of anti-L-selectin antibodies . Regulation CA2 SNCAIP 11602242 870966 The effect appears to be specific as neither ceramide nor had any *effect* on the NO and [[Ca2+] ] i levels . Regulation CA2 SPHK1 9582276 503824 The present study investigated whether activation , leading to production of sphingosine-1-phosphate (SPP) , is *involved* in GPCR mediated [Ca2+] signalling as proposed for platelet derived growth factor and FcepsilonRI antigen receptors . Regulation CA2 TF 9461291 475787 Consequently , we examined the *role* of in internal free [Ca2+] regulation . Regulation CA2 TMOD1 2142896 137561 Effect of thyroid status on [Ca2+] *regulation* and expression of troponin I in perinatal and adult rat hearts . Regulation CA2 TMOD1 2934055 53991 We propose that caldesmon based [Ca2+] *regulation* is a physiological mechanism in all smooth muscles . Regulation CA2 TMOD1 7858135 287038 The similarity of activation dependence of VUS whether fibers were activated in a Ca ( 2+ ) -sensitive or -insensitive manners implies that VUS is determined by the average level of activation and that , with sTnC or cTnC , VUS is *affected* by [Ca2+] binding to TnC only . Regulation CA2 TNF 10379905 623944 Neither IL-6 nor , *affected* cytoplasmic [Ca2+] of the cells . Regulation CA2 TNF 11223011 787804 We have now investigated the *effect* of on the glutamate induced intracellular [Ca2+] increase in astrocytes , a process which seems to be involved in glial mediated modulation of neuronal synaptic transmisssion . Regulation CA2 TNF 11749775 889805 To study the *effect* of on intracellular free [Ca2+ concentration ([Ca2+]i)] and the effects of verapamil ( Ver ) , cyproheptadine ( Cyp ) , and anisodamine ( Ani ) on TNFalpha induced [ Ca2+ ] i changes in single endothelial cell , and to explore the mechanisms of TNFalpha mediated shock and antishock actions of Cyp and Ani . Regulation CA2 TNF 1847937 153532 To determine whether this disorder involves a genetically determined abnormal response to cytokines , the *effects* of and IL-1 on intracellular free [Ca2+] were compared in cultured skin fibroblasts from control subjects and patients with RS . Regulation CA2 TNF 19922794 2184725 Through the experimental isolation of each AD-related transgene , it was determined that expression of the PS1M146V transgene product is responsible for the loss of the *effect* on IP3R mediated [Ca2+] release . Regulation CA2 TNF 9316456 456173 Although TSH stimulation of H2O2 production is mediated by the phospholipase C (PLC)-Ca2+ pathway , and exogenous and endogenous ceramide *affected* neither TSH dependent PLC activation and [Ca2+] mobilization nor TSH induced cAMP accumulation but attenuated Ca ( 2+ ) -induced H2O2 production . Regulation CA2 TNF 9374730 465306 In addition , cycloheximide , a protein synthesis inhibitor , completely blocked the potentiating *effect* of on [Ca2+] signals . Regulation CA2 TNF 9915989 587445 The focus of the current study was to examine the role of ceramide in induced [Ca2+] *regulation* . Regulation CA5A EPHB2 17996937 1903200 Thus , *dependent* regulation of [Ca(v)] activity provides an elegant and extremely flexible system with which to tailor calcium influx to discrete functional demands . Regulation CA9 EPHB2 16270297 1502363 Thus , although ERK signaling is required for optimal CAIX expression , our data are consistent with a model in which constitutive basal activity *plays* an auxiliary role in [CA9] promoter transactivation by modulating activity of the transcription factor SP1 and the transcriptional co-activator p300 . Regulation CABP4 ATP5O 10569182 567965 Expression of [calcium binding protein] regucalcin and microsomal *regulation* in rat brain : attenuation with increasing age . Regulation CABP4 BDNF 14625444 1170214 Using BDNF null mutant (BDNF-/-) mice and mice where the protein coding DNA sequence of BDNF has been replaced by NT3 ( BDNFNT3/NT3 mice ) , we have analysed the *roles* of and NT3 in controlling neuropeptide and [calcium binding protein] expression in the brain . Regulation CABP4 CA2 10569182 567964 Expression of [calcium binding protein] regucalcin and microsomal *regulation* in rat brain : attenuation with increasing age . Regulation CABP4 CA2 2736040 114579 S100b is a [calcium binding protein] that will bind to many calmodulin target molecules in a *dependent* manner . Regulation CABP4 CALB1 8584029 341339 Retinoic acid *regulates* the expression of the [calcium binding protein] , . Regulation CABP4 SNRK 21098029 2383306 Here , we report that interact with and are *regulated* by a plant-specific [calcium binding protein] . Regulation CABP4 SORT1 14625444 1170215 Using BDNF null mutant (BDNF-/-) mice and mice where the protein coding DNA sequence of BDNF has been replaced by NT3 ( BDNFNT3/NT3 mice ) , we have analysed the *roles* of BDNF and in controlling neuropeptide and [calcium binding protein] expression in the brain . Regulation CADM1 TNF 23328772 2738413 *Effect* of blockade on mucosal addressin [cell-adhesion molecule-1] in Crohn 's disease . Regulation CALCB IL1B 17481780 1750516 deletion analysis identified an AP-1 consensus site at -643bp relative to the initiation site , which mediates the [beta-CGRP] gene transcription in *response* to . Regulation CALCR ITGB2 11134042 786696 The yeast transcription factor *plays* a critical role in the transcriptional regulation of [CTR1] and CTR3 , both encoding high affinity copper ion transporters . Regulation CALD1 CABP4 1445920 205260 Calcium dependent *regulation* of [caldesmon] by an 11-kDa smooth muscle , caltropin . Regulation CALD1 EPHB2 15072969 1232648 PDBu produced time dependent increases in phosphorylation of p42 and p44 ERK and *dependent* phosphorylation of [caldesmon] at Ser789 in the uterine artery . Regulation CALM3 CAPN8 1328642 197890 These findings and the existence of PEDST sequences suggest that the JFP is normally degraded by in vivo and that degradation is *regulated* by calpastatin and [calmodulin] . Regulation CALM3 CDKN1C 2952648 71176 It is proposed that P-57 binds and localizes calmodulin at specific sites within the cell and that free [calmodulin] is released locally in *response* to phosphorylation of by protein kinase C and/or to increases in intracellular free Ca2+ . Regulation CALM3 DAPK1 24220854 2897371 Both and DRP-1 possess a conserved CaM autoregulatory domain , and are *regulated* by calcium activated [CaM] and by an inhibitory auto-phosphorylation within the domain . Regulation CALM3 FAS 15965236 1440849 The *effects* of binding on [calmodulin] antagonist induced apoptosis may open a new avenue for therapy for osteoporosis . Regulation CALM3 IL1B 12127053 966086 stimulation had no *effect* on endothelial [CAM] expression . Regulation CALM3 MIP 18081321 1854513 The purpose of the present study was to elucidate the *role* of phosphorylation on [calmodulin] binding . Regulation CALM3 MIP 18081321 1854514 These data suggest that C-terminal phosphorylation *affects* [calmodulin] binding in vivo and has a role in regulation of AQP0 function . Regulation CALM3 STK39 19521987 2116189 DAPK1 , a ca ( +2 ) [/calmodulin] *regulated* , is a major tumor suppressor , whose expression is lost in multiple tumor types . Regulation CALM3 TNF 10072259 594428 Similarly , the inhibition of EC protein kinase C ( PKC ) and tyrosine kinase ( TK ) pathways modulates mediated *effects* on [CAM] expression . Regulation CAMK4 NR2F1 12403833 1009682 A single element confers T ( 3 ) and *regulation* of [CaMKIV] expression . Regulation CANX EPHB2 15513932 1354909 Furthermore , the phosphorylation of p90RSK and histone H3 were both antagonized by the MEK inhibitor U0126 , implying that SeMet induced phosphorylation of [p90RSK] and histone H3 are at least in part pathway *dependent* . Regulation CAPN1 IFI27 21544553 2440313 Collectively , [calpain] *regulates* cell proliferative function by modulating both transcription and degradation of ( Kip1 ) in osteoblasts . Regulation CAPN1 TMEM100 2831893 85543 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN1 TMEM156 2831893 85561 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN1 TMEM211 2831893 85641 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN1 TMEM213 2831893 85578 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN10 IFI27 21544553 2440314 Collectively , [calpain] *regulates* cell proliferative function by modulating both transcription and degradation of ( Kip1 ) in osteoblasts . Regulation CAPN10 TMEM100 2831893 85712 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN10 TMEM156 2831893 85730 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN10 TMEM211 2831893 85810 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN10 TMEM213 2831893 85747 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN11 IFI27 21544553 2440315 Collectively , [calpain] *regulates* cell proliferative function by modulating both transcription and degradation of ( Kip1 ) in osteoblasts . Regulation CAPN11 TMEM100 2831893 85881 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN11 TMEM156 2831893 85899 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN11 TMEM211 2831893 85979 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN11 TMEM213 2831893 85916 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN12 IFI27 21544553 2440312 Collectively , [calpain] *regulates* cell proliferative function by modulating both transcription and degradation of ( Kip1 ) in osteoblasts . Regulation CAPN12 TMEM100 2831893 85304 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN12 TMEM156 2831893 85322 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN12 TMEM211 2831893 85402 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN12 TMEM213 2831893 85339 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN13 IFI27 21544553 2440323 Collectively , [calpain] *regulates* cell proliferative function by modulating both transcription and degradation of ( Kip1 ) in osteoblasts . Regulation CAPN13 TMEM100 2831893 87247 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN13 TMEM156 2831893 87265 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN13 TMEM211 2831893 87345 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN13 TMEM213 2831893 87282 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN14 IFI27 21544553 2440324 Collectively , [calpain] *regulates* cell proliferative function by modulating both transcription and degradation of ( Kip1 ) in osteoblasts . Regulation CAPN14 TMEM100 2831893 87416 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN14 TMEM156 2831893 87434 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN14 TMEM211 2831893 87514 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN14 TMEM213 2831893 87451 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN15 IFI27 21544553 2440311 Collectively , [calpain] *regulates* cell proliferative function by modulating both transcription and degradation of ( Kip1 ) in osteoblasts . Regulation CAPN15 TMEM100 2831893 85093 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN15 TMEM156 2831893 85111 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN15 TMEM211 2831893 85191 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN15 TMEM213 2831893 85128 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN2 CAPN8 10631089 659680 *Effect* of on [m-calpain] . Regulation CAPN2 EPHB2 19946123 2190647 *regulates* [calpain 2-induced] androgen receptor proteolysis in CWR22 relapsed prostate tumor cell lines . Regulation CAPN2 IFI27 21544553 2440316 Collectively , [calpain] *regulates* cell proliferative function by modulating both transcription and degradation of ( Kip1 ) in osteoblasts . Regulation CAPN2 TMEM100 2831893 86050 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN2 TMEM156 2831893 86068 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN2 TMEM211 2831893 86148 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN2 TMEM213 2831893 86085 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN3 IFI27 21544553 2440317 Collectively , [calpain] *regulates* cell proliferative function by modulating both transcription and degradation of ( Kip1 ) in osteoblasts . Regulation CAPN3 TMEM100 2831893 86219 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN3 TMEM156 2831893 86237 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN3 TMEM211 2831893 86317 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN3 TMEM213 2831893 86254 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN5 IFI27 21544553 2440318 Collectively , [calpain] *regulates* cell proliferative function by modulating both transcription and degradation of ( Kip1 ) in osteoblasts . Regulation CAPN5 TMEM100 2831893 86388 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN5 TMEM156 2831893 86406 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN5 TMEM211 2831893 86486 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN5 TMEM213 2831893 86423 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN6 IFI27 21544553 2440319 Collectively , [calpain] *regulates* cell proliferative function by modulating both transcription and degradation of ( Kip1 ) in osteoblasts . Regulation CAPN6 TMEM100 2831893 86557 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN6 TMEM156 2831893 86575 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN6 TMEM211 2831893 86655 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN6 TMEM213 2831893 86592 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN7 IFI27 21544553 2440320 Collectively , [calpain] *regulates* cell proliferative function by modulating both transcription and degradation of ( Kip1 ) in osteoblasts . Regulation CAPN7 TMEM100 2831893 86726 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN7 TMEM156 2831893 86744 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN7 TMEM211 2831893 86824 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN7 TMEM213 2831893 86761 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 ADRBK1 16963227 1673451 The hydrogen peroxide induced decrease in GRK2 is prevented by a [calpain] protease inhibitor , but does not *involve* increased GRK2 degradation or changes in mRNA level . Regulation CAPN8 AGRN 17640526 1771164 Interestingly , the AChR associated protein rapsyn interacted with [calpain] in an *dependent* manner , and this interaction inhibited the protease activity of calpain . Regulation CAPN8 AKT1 19946330 2217309 Together , by regulating the activation of HER2 and , [calpain] *regulates* trastuzumab sensitivity and survival , and the deregulation of the activation of calpain promotes trastuzumab resistance . Regulation CAPN8 APLN 23290264 2725469 However , the *effects* of on ABCA1 protein expression , cellular cholesterol efflux and [calpain] activity were abolished by depletion of PKCa , suggesting the potential important role of PKCa . Regulation CAPN8 CA2 10384098 624729 Two lines of evidence indicate that the *dependent* cysteine protease [calpain] plays a major role in initiating ZAP-70 degradation : 1 ) treatment of T cells with cell permeating inhibitors of calpain markedly reduces ZAP-70 degradation ; Regulation CAPN8 CA2 1365908 209496 It seems likely that [calpain] activity is *regulated* by binding of to specific sites on the calpain molecule , with binding to each site eliciting a response ( proteolytic activity , calpastatin binding , etc. ) specific for that site . Regulation CAPN8 CA2 18268335 1871944 A small molecule ( S107 ) that prevents depletion of calstabin1 from the RyR1 complex improved force generation and exercise capacity , reduced *dependent* neutral protease [calpain] activity and plasma creatine kinase levels . Regulation CAPN8 CALM3 1328642 197910 These findings and the existence of PEDST sequences suggest that the JFP is normally degraded by [calpain] in vivo and that degradation is *regulated* by calpastatin and . Regulation CAPN8 CAPN1 19857102 2156491 ( mu-calpain ) and calpain 2 ( m-calpain ) are the 2 major typical calpain isoforms and are *responsible* for most [calpain] activity in endothelial cells . Regulation CAPN8 CAPN2 16433929 1665592 Disruption of the Capn1 gene produced viable , fertile mice implying that either m-calpain could compensate for the loss of [mu-calpain] , or that the loss of was *responsible* for death of Capn4-/- mice . Regulation CAPN8 CAPN2 19857102 2156492 Calpain 1 ( mu-calpain ) and ( m-calpain ) are the 2 major typical calpain isoforms and are *responsible* for most [calpain] activity in endothelial cells . Regulation CAPN8 CAPNS1 19857102 2156493 Calpain 1 ( mu-calpain ) and ( m-calpain ) are the 2 major typical calpain isoforms and are *responsible* for most [calpain] activity in endothelial cells . Regulation CAPN8 CASP1 11413236 828830 Cleavage of Bax is mediated by *dependent* or -independent [calpain] activation in dopaminergic neuronal cells : protective role of Bcl-2 . Regulation CAPN8 CASP1 12175527 974910 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Regulation CAPN8 CASP1 17498717 1772585 In contrast , inhibitor did not *affect* E. histolytica induced [calpain] activation . Regulation CAPN8 CASP1 20406947 2256302 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , *dependent* amplification of mitochondrial depolarization , activation of [calpain] , and Bax cleavage . Regulation CAPN8 CASP10 11413236 828831 Cleavage of Bax is mediated by *dependent* or -independent [calpain] activation in dopaminergic neuronal cells : protective role of Bcl-2 . Regulation CAPN8 CASP10 12175527 974911 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Regulation CAPN8 CASP10 17498717 1772586 In contrast , inhibitor did not *affect* E. histolytica induced [calpain] activation . Regulation CAPN8 CASP10 20406947 2256303 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , *dependent* amplification of mitochondrial depolarization , activation of [calpain] , and Bax cleavage . Regulation CAPN8 CASP12 11413236 828841 Cleavage of Bax is mediated by *dependent* or -independent [calpain] activation in dopaminergic neuronal cells : protective role of Bcl-2 . Regulation CAPN8 CASP12 12175527 974921 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Regulation CAPN8 CASP12 17498717 1772596 In contrast , inhibitor did not *affect* E. histolytica induced [calpain] activation . Regulation CAPN8 CASP12 20406947 2256313 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , *dependent* amplification of mitochondrial depolarization , activation of [calpain] , and Bax cleavage . Regulation CAPN8 CASP14 11413236 828832 Cleavage of Bax is mediated by *dependent* or -independent [calpain] activation in dopaminergic neuronal cells : protective role of Bcl-2 . Regulation CAPN8 CASP14 12175527 974912 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Regulation CAPN8 CASP14 17498717 1772587 In contrast , inhibitor did not *affect* E. histolytica induced [calpain] activation . Regulation CAPN8 CASP14 20406947 2256304 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , *dependent* amplification of mitochondrial depolarization , activation of [calpain] , and Bax cleavage . Regulation CAPN8 CASP16 11413236 828842 Cleavage of Bax is mediated by *dependent* or -independent [calpain] activation in dopaminergic neuronal cells : protective role of Bcl-2 . Regulation CAPN8 CASP16 12175527 974922 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Regulation CAPN8 CASP16 17498717 1772597 In contrast , inhibitor did not *affect* E. histolytica induced [calpain] activation . Regulation CAPN8 CASP16 20406947 2256314 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , *dependent* amplification of mitochondrial depolarization , activation of [calpain] , and Bax cleavage . Regulation CAPN8 CASP2 11413236 828833 Cleavage of Bax is mediated by *dependent* or -independent [calpain] activation in dopaminergic neuronal cells : protective role of Bcl-2 . Regulation CAPN8 CASP2 12175527 974913 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Regulation CAPN8 CASP2 17498717 1772588 In contrast , inhibitor did not *affect* E. histolytica induced [calpain] activation . Regulation CAPN8 CASP2 20406947 2256305 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , *dependent* amplification of mitochondrial depolarization , activation of [calpain] , and Bax cleavage . Regulation CAPN8 CASP3 11413236 828834 Cleavage of Bax is mediated by *dependent* or -independent [calpain] activation in dopaminergic neuronal cells : protective role of Bcl-2 . Regulation CAPN8 CASP3 12175527 974914 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Regulation CAPN8 CASP3 15304031 1284426 PS exposure in agonist stimulated platelets was markedly reduced by inhibition of activity but was not *affected* by inhibition of [calpain] activity . Regulation CAPN8 CASP3 17498717 1772589 In contrast , inhibitor did not *affect* E. histolytica induced [calpain] activation . Regulation CAPN8 CASP3 18270815 1924710 Results show no activity , but a strong [calpain] activation *involving* both NMDA and non-NMDA receptors . Regulation CAPN8 CASP3 20406947 2256306 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , *dependent* amplification of mitochondrial depolarization , activation of [calpain] , and Bax cleavage . Regulation CAPN8 CASP4 11413236 828835 Cleavage of Bax is mediated by *dependent* or -independent [calpain] activation in dopaminergic neuronal cells : protective role of Bcl-2 . Regulation CAPN8 CASP4 12175527 974915 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Regulation CAPN8 CASP4 17498717 1772590 In contrast , inhibitor did not *affect* E. histolytica induced [calpain] activation . Regulation CAPN8 CASP4 20406947 2256307 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , *dependent* amplification of mitochondrial depolarization , activation of [calpain] , and Bax cleavage . Regulation CAPN8 CASP5 11413236 828836 Cleavage of Bax is mediated by *dependent* or -independent [calpain] activation in dopaminergic neuronal cells : protective role of Bcl-2 . Regulation CAPN8 CASP5 12175527 974916 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Regulation CAPN8 CASP5 17498717 1772591 In contrast , inhibitor did not *affect* E. histolytica induced [calpain] activation . Regulation CAPN8 CASP5 20406947 2256308 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , *dependent* amplification of mitochondrial depolarization , activation of [calpain] , and Bax cleavage . Regulation CAPN8 CASP6 11413236 828837 Cleavage of Bax is mediated by *dependent* or -independent [calpain] activation in dopaminergic neuronal cells : protective role of Bcl-2 . Regulation CAPN8 CASP6 12175527 974917 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Regulation CAPN8 CASP6 17498717 1772592 In contrast , inhibitor did not *affect* E. histolytica induced [calpain] activation . Regulation CAPN8 CASP6 20406947 2256309 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , *dependent* amplification of mitochondrial depolarization , activation of [calpain] , and Bax cleavage . Regulation CAPN8 CASP7 11413236 828838 Cleavage of Bax is mediated by *dependent* or -independent [calpain] activation in dopaminergic neuronal cells : protective role of Bcl-2 . Regulation CAPN8 CASP7 12175527 974918 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Regulation CAPN8 CASP7 17498717 1772593 In contrast , inhibitor did not *affect* E. histolytica induced [calpain] activation . Regulation CAPN8 CASP7 20406947 2256310 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , *dependent* amplification of mitochondrial depolarization , activation of [calpain] , and Bax cleavage . Regulation CAPN8 CASP8 11413236 828839 Cleavage of Bax is mediated by *dependent* or -independent [calpain] activation in dopaminergic neuronal cells : protective role of Bcl-2 . Regulation CAPN8 CASP8 12175527 974919 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Regulation CAPN8 CASP8 17498717 1772594 In contrast , inhibitor did not *affect* E. histolytica induced [calpain] activation . Regulation CAPN8 CASP8 20406947 2256311 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , *dependent* amplification of mitochondrial depolarization , activation of [calpain] , and Bax cleavage . Regulation CAPN8 CASP9 11413236 828840 Cleavage of Bax is mediated by *dependent* or -independent [calpain] activation in dopaminergic neuronal cells : protective role of Bcl-2 . Regulation CAPN8 CASP9 12175527 974920 These results suggested that Bax cleavage is mediated by calpain , and [calpain] activation may be a *dependent* one . Regulation CAPN8 CASP9 17498717 1772595 In contrast , inhibitor did not *affect* E. histolytica induced [calpain] activation . Regulation CAPN8 CASP9 20406947 2256312 Moreover , MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9 , *dependent* amplification of mitochondrial depolarization , activation of [calpain] , and Bax cleavage . Regulation CAPN8 CAST 10966930 728267 Because intracellular [calpain] activity is *regulated* by , the effect of I/R on calpastatin was determined . Regulation CAPN8 CAST 11553520 858279 and 3 ) the *effect* of a ( PD-150606 ) on [calpain] levels , mitochondrial function , and ion transport during RPT injury . Regulation CAPN8 CAST 12500971 1056843 An important key to understanding [calpain] *regulation* by is to determine , at the molecular level , how calpastatin interacts with calpain to inhibit its enzymatic activity . Regulation CAPN8 CAST 12769798 1094612 , an endogenous protein inhibitor , *regulates* the activity of ubiquitous [calpain] . Regulation CAPN8 CAST 1328642 197911 These findings and the existence of PEDST sequences suggest that the JFP is normally degraded by [calpain] in vivo and that degradation is *regulated* by and calmodulin . Regulation CAPN8 CAST 1365908 209468 Is [calpain] activity *regulated* by membranes and autolysis or by calcium and ? Regulation CAPN8 CAST 1388013 196317 The presence of low levels of activity in erythrocytes of hypertensive rats *affects* regulation of [calpain] activity so it is highly susceptible to activation within physiological fluctuations in [Ca2+ ] . Regulation CAPN8 CAST 1388013 196331 Under identical conditions , in red cells of normotensive rats , [calpain] activation is efficiently *controlled* by the high levels of activity , and a progressive increase in proteinase activity can only be observed in parallel with a decrease in the level of calpastatin . Regulation CAPN8 CAST 14630341 1170459 The activity of [calpain] is strictly *regulated* by calcium concentrations and interactions with ( endogenous calpain inhibitor ) . Regulation CAPN8 CAST 14992597 1215711 In vivo , the activity of [calpain] is *regulated* by its endogenous inhibitor . Regulation CAPN8 CAST 14996907 1220473 *Regulation* of [calpain] activity by thus provides a mechanism for regulating the anchoring of basal bodies to the apical cytoskeleton in ciliated cells . Regulation CAPN8 CAST 17513017 1797921 levels *affect* [calpain] activation and calpain proteolytic activity in APP transgenic mouse model of Alzheimer 's disease . Regulation CAPN8 CAST 17881114 1858351 Besides its regulation by calcium , [calpain] activity is tightly *controlled* by , the specific endogenous inhibitor , binding to phospholipids , autoproteolysis and phosphorylation . Regulation CAPN8 CAST 18519038 1922529 The activity of [calpain] is *controlled* by the free intracellular calcium level and by the protein 's intrinsically disordered endogenous inhibitor , , mediated by short conserved segments : subdomains A-C . Regulation CAPN8 CAST 22062540 1358824 The data presented in this paper show evidence that sarcomere length is the main determinant of background toughness in ovine longissimus , and that postmortem proteolysis , resulting from [µ-calpain] activity *regulated* by , is the main determinant of ovine longissimus tenderization during aging . Regulation CAPN8 CAST 22366408 2612449 , the negative [calpain] *regulator* , was expressed at much lower levels in Eµ-myc lymphoma cells compared to normal splenic B cells . Regulation CAPN8 CAST 22829235 2635303 Previous work has shown that c-myc transformation *regulates* [calpain] activity by suppressing , the endogenous negative regulator of calpain . Regulation CAPN8 CAST 22897874 2666519 The purpose of the present study was to investigate the functional *role* of , a specific endogenous calpain inhibitor protein , on caspase and [calpain] activation in METH induced degeneration in neuroblastoma SH-SY5Y cell cultures . Regulation CAPN8 CAST 23545741 2763021 Under the physiological conditions , [calpain] activity is strictly *regulated* by endogenous inhibitory protein , . Regulation CAPN8 CAST 2992872 50384 The inhibitory *effect* of ( specific inhibitor for calpain ) on [calpain] ( Ca2+ dependent cysteine proteinase , EC 3.4.22.17 ) was examined using carp muscle , carp erythrocytes and rat liver preparations . Regulation CAPN8 CAST 7982901 281634 These results suggest that serves not only as an inhibitor but also as a substrate for calpain at cell membranes and that intracellular conditions associated with the cell cycle may *affect* the activation of [mu-calpain] . Regulation CAPN8 CAST 9180207 434462 Because calpastatin is not only a potent inhibitor but also a preferred substrate for calpain and because CA2 neurons are less vulnerable to ischemic stress than the adjacent CA1 neurons , these observations imply *involvement* of in [calpain] regulation as a bait substrate and , possibly , in neuroprotection under ischemic conditions . Regulation CAPN8 CD3EAP 21450414 2422024 This study aimed to detect variability in CAST , CAPN1 and CAPN3 porcine genes and to investigate the *effect* of and CAPN1 polymorphisms on the activity of native and autolyzed [µ-calpain] and m-calpain , measured from 1 to 72 h post-mortem in Longissimus dorsi ( LD ) muscle of 30 pigs . Regulation CAPN8 CPN2 18455725 1921336 Our findings introduce the possibility that reversible phosphorylation of *regulates* its ability to activate [calpain] in phosphatase inhibitor induced apoptosis and controls the cellular accessibility of long-chain fatty acid-CoAs for cellular signaling . Regulation CAPN8 CSE 16100081 1466550 Overexpression of calpastatin mimics the inhibitory *effects* of on [calpain] activity and on the activity , protein , and mRNA of eNOS . Regulation CAPN8 CSF3 18524991 1952019 Thus , neutrophil apoptosis is *controlled* by after initial activation of caspase-8 and mitochondrial permeabilization by the control of postmitochondrial [calpain] activity . Regulation CAPN8 DLG4 18445709 1938597 These data suggest that [calpain] activation suppresses NMDAR function via proteolytic cleavage of NR2 subunits in vitro and in vivo , and the susceptibility of NMDARs to calpain cleavage is *controlled* by and calcineurin . Regulation CAPN8 ERBB2 19946330 2217308 Together , by regulating the activation of and PTEN/AKT1 , [calpain] *regulates* trastuzumab sensitivity and survival , and the deregulation of the activation of calpain promotes trastuzumab resistance . Regulation CAPN8 HTT 12460554 1021852 However , they suggest that [calpain] activation and *regulation* merit investigation as modifiers of disease progression in neurons injured by the harmful consequences of full-length mutant huntingtin . Regulation CAPN8 IFI27 21544553 2440321 Collectively , [calpain] *regulates* cell proliferative function by modulating both transcription and degradation of ( Kip1 ) in osteoblasts . Regulation CAPN8 IGF1 17433758 1748997 The aim of this study was to identify the signalling pathway ( s ) responsible for the *effects* of , TGF-beta1 , and insulin on myoblast migration and on [milli-calpain] expression and activity . Regulation CAPN8 INS 17433758 1748998 The aim of this study was to identify the signalling pathway ( s ) responsible for the *effects* of IGF-1 , TGF-beta1 , and on myoblast migration and on [milli-calpain] expression and activity . Regulation CAPN8 LCN2 19830249 2149084 The kinase is typically activated by , derived from p35 by calpain mediated cleavage , but inhibition of [calpain] does not *affect* cell death or the activation of Cdk5 . Regulation CAPN8 MYC 18544539 1940521 *Regulation* of [calpain] activity by through calpastatin and promotion of transformation in c-Myc negative cells by calpastatin suppression . Regulation CAPN8 PCNA 1829675 161394 proteolysis at micromolar free Ca2+ , is not inhibited by calpastatin , and therefore does not *involve* [calpain] . Regulation CAPN8 PPP3CA 18445709 1938598 These data suggest that [calpain] activation suppresses NMDAR function via proteolytic cleavage of NR2 subunits in vitro and in vivo , and the susceptibility of NMDARs to calpain cleavage is *controlled* by PSD-95 and . Regulation CAPN8 PPP3R1 18445709 1938599 These data suggest that [calpain] activation suppresses NMDAR function via proteolytic cleavage of NR2 subunits in vitro and in vivo , and the susceptibility of NMDARs to calpain cleavage is *controlled* by PSD-95 and . Regulation CAPN8 PTEN 19946330 2217310 Together , by regulating the activation of HER2 and , [calpain] *regulates* trastuzumab sensitivity and survival , and the deregulation of the activation of calpain promotes trastuzumab resistance . Regulation CAPN8 TGFB1 17433758 1748996 The aim of this study was to identify the signalling pathway ( s ) responsible for the *effects* of IGF-1 , , and insulin on myoblast migration and on [milli-calpain] expression and activity . Regulation CAPN8 TMEM100 2831893 86895 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM101 2831893 86961 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM102 2831893 86924 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM104 2831893 86904 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM105 2831893 86926 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM107 2831893 86941 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM108 2831893 86954 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM109 2831893 86963 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM11 2831893 86847 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM110 2831893 86975 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM114 2831893 86989 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM115 2831893 86969 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM116 2831893 86875 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM117 2831893 86883 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM119 2831893 86935 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM121 2831893 86857 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM123 2831893 86971 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM125 2831893 86949 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM127 2831893 86905 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM128 2831893 86946 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM129 2831893 86878 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM130 2831893 86886 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM131 2831893 86973 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM133 2831893 86869 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM134 2831893 86908 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM135 2831893 86909 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM136 2831893 86950 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM138 2831893 86928 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM139 2831893 86866 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM140 2831893 86863 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM141 2831893 86947 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM143 2831893 86893 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM144 2831893 86898 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM145 2831893 86927 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM147 2831893 86974 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM154 2831893 86919 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM155 2831893 86917 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM156 2831893 86913 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM158 2831893 86972 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM159 2831893 86970 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM160 2831893 86906 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM163 2831893 86885 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM164 2831893 86912 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM165 2831893 86977 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM168 2831893 86900 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM169 2831893 86877 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM17 2831893 86923 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM171 2831893 86929 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM173 2831893 86938 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM174 2831893 86944 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM175 2831893 86962 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM177 2831893 86942 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM179 2831893 86854 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM18 2831893 86882 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM180 2831893 86911 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM181 2831893 86858 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM182 2831893 86915 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM186 2831893 86872 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM187 2831893 86842 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM189 2831893 86846 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM19 2831893 86894 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM190 2831893 86968 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM192 2831893 86925 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM196 2831893 86867 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM198 2831893 86990 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM199 2831893 86850 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM2 2831893 86838 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM201 2831893 86992 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM202 2831893 86994 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM203 2831893 86948 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM204 2831893 86843 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM205 2831893 86967 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM206 2831893 86892 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM207 2831893 86991 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM208 2831893 86873 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM209 2831893 86864 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM210 2831893 86997 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM211 2831893 86993 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM212 2831893 86998 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM213 2831893 86930 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM214 2831893 86903 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM215 2831893 86996 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM216 2831893 86874 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM217 2831893 86859 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM218 2831893 86932 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM219 2831893 86880 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM220 2831893 86995 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM221 2831893 86865 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM222 2831893 86884 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM223 2831893 86955 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM225 2831893 86986 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM230 2831893 86845 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM231 2831893 87000 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM232 2831893 87001 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM233 2831893 86999 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM234 2831893 86965 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM235 2831893 86934 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM236 2831893 86868 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM237 2831893 86844 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM238 2831893 87002 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM239 2831893 87003 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM240 2831893 86879 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM241 2831893 86979 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM242 2831893 86849 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM243 2831893 86861 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM244 2831893 86860 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM245 2831893 86841 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM246 2831893 86943 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM247 2831893 87004 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM248 2831893 86888 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM249 2831893 87005 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM25 2831893 86902 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM251 2831893 86856 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM252 2831893 86957 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM253 2831893 86988 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM254 2831893 86899 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM256 2831893 86960 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM257 2831893 86896 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM258 2831893 86837 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM259 2831893 86848 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM26 2831893 86958 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM260 2831893 86855 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM261 2831893 86976 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM27 2831893 86966 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM31 2831893 86959 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM33 2831893 86890 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM35 2831893 86901 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM37 2831893 86851 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM40 2831893 86897 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM42 2831893 86953 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM43 2831893 86956 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM44 2831893 86876 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM47 2831893 86852 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM5 2831893 86840 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM51 2831893 86889 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM52 2831893 86937 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM53 2831893 86910 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM54 2831893 86870 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM56 2831893 86918 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM57 2831893 86891 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM59 2831893 86839 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM60 2831893 86862 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM61 2831893 86931 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM62 2831893 86914 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM64 2831893 86887 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM65 2831893 86881 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM66 2831893 86964 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM67 2831893 86952 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM68 2831893 86920 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM69 2831893 86939 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM70 2831893 86907 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM71 2831893 86921 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM72 2831893 86978 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM74 2831893 86916 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM75 2831893 86980 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM78 2831893 86981 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM79 2831893 86945 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM80 2831893 86933 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM81 2831893 86982 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM82 2831893 86983 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM88 2831893 86984 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM89 2831893 86985 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM9 2831893 86853 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM91 2831893 86987 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM92 2831893 86922 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM95 2831893 86936 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM97 2831893 86940 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM98 2831893 86871 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TMEM99 2831893 86951 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN8 TNFSF11 15955824 1440705 We found that calpain activity increased in *response* to in both cell types based on alpha-spectrinolysis and that [mu-calpain] , rather than m-calpain , was activated during RANKL supported osteoclastogenesis in RAW 264.7 cells . Regulation CAPN8 UPP1 24681580 2938680 Also , inhibition of the does not *affect* MV-induced increases in [calpain] and caspase-3 activity in the diaphragm . Regulation CAPN8 UPP2 24681580 2938681 Also , inhibition of the does not *affect* MV-induced increases in [calpain] and caspase-3 activity in the diaphragm . Regulation CAPN9 IFI27 21544553 2440322 Collectively , [calpain] *regulates* cell proliferative function by modulating both transcription and degradation of ( Kip1 ) in osteoblasts . Regulation CAPN9 TMEM100 2831893 87064 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN9 TMEM156 2831893 87082 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN9 TMEM211 2831893 87162 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPN9 TMEM213 2831893 87099 Our findings suggest that [calpain] activity may *control* , both at a functional and at a structural level , the activity of this important through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation CAPNS1 EPHB2 19946123 2190648 *regulates* [calpain 2-induced] androgen receptor proteolysis in CWR22 relapsed prostate tumor cell lines . Regulation CAPS IL1B 19501000 2098119 The central *role* of in [CAPS] is supported by the response to IL-1 targeted therapy . Regulation CAPS IL1B 19649332 2118960 Kineret ( R ) or anakinra/ Amgen , Inc. ) , not only provided supportive evidence for the *role* of in [CAPS] but also demonstrated the efficacy of targeting IL-1beta for treatment of these conditions . Regulation CAPS IL1B 19707454 2009178 The selective blockade of IL-1beta , with anakinra ( IL-1 receptor antagonist ) , not only provided supportive evidence for the *role* of in [CAPS] , but also demonstrated the efficacy of targeting IL-1beta for treatment of these conditions . Regulation CARD8 TNF 23687262 2932194 This study found evidence of modulation of the NLRP3-inflammasome in patients with RA prior to receiving infliximab and some evidence of association for SNPs at NLRP3 and [CARD8] loci with RA susceptibility and *response* to . Regulation CASP1 CAPN8 11449356 836339 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Regulation CASP1 EPHB2 15304372 1322278 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Regulation CASP1 EPHB2 19709398 2139152 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Regulation CASP1 EPHB2 21364665 2361172 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP1 FAS 10403377 629001 We evaluated the *effects* of antibody engagement on [caspase] activation and mitochondrial permeability , and the impact of co-stimulation by lipopolysaccharide (LPS) or granulocyte macrophage-colony stimulating factor ( GM-CSF ) on these events . Regulation CASP1 FAS 12393594 1031532 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Regulation CASP1 FAS 16120269 895983 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Regulation CASP1 FAS 16330535 1511998 costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and [caspase] activity . Regulation CASP1 FAS 8912630 395409 CPP32 , but not [ICE] , was activated in *response* to stimulation . Regulation CASP1 FAS 9421482 481196 Similar effects were obtained when cells were treated with synthetic [ICE] inhibitors , which blocked apoptosis in *response* to triggering . Regulation CASP1 IL1B 9341755 458754 It is concluded that psoriatic scales contain biologically active , which has been processed by a mechanism which may be similar to that present in non inflamed plantar stratum corneum , and which does not *involve* [IL-1 beta converting enzyme] . Regulation CASP1 MAP2K6 21364665 2361178 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP1 SPHK1 11238741 791100 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Regulation CASP1 TGM2 17003418 1618476 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Regulation CASP1 TNF 10593992 572969 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Regulation CASP1 TNF 15050407 1229375 P38 mediated [caspase] activation regulates mercury induced apoptosis and p38 mediated *regulates* necrosis in these cells . Regulation CASP1 TNF 18231987 1895649 A longer treatment with DENSPM however reduced [caspase] *response* to plus CHX . Regulation CASP1 TNFSF10 15197350 1347083 Our data also show that impaired formation in the presence of TPCK is *responsible* for [caspase] inhibition . Regulation CASP10 CAPN8 11449356 836353 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Regulation CASP10 EPHB2 15304372 1322279 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Regulation CASP10 EPHB2 19709398 2139154 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Regulation CASP10 EPHB2 21364665 2361180 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP10 FAS 10403377 629002 We evaluated the *effects* of antibody engagement on [caspase] activation and mitochondrial permeability , and the impact of co-stimulation by lipopolysaccharide (LPS) or granulocyte macrophage-colony stimulating factor ( GM-CSF ) on these events . Regulation CASP10 FAS 12393594 1031533 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Regulation CASP10 FAS 16120269 895984 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Regulation CASP10 FAS 16330535 1511999 costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and [caspase] activity . Regulation CASP10 MAP2K6 21364665 2361186 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP10 SPHK1 11238741 791102 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Regulation CASP10 TGM2 17003418 1618483 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Regulation CASP10 TNF 10593992 572970 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Regulation CASP10 TNF 14687710 1179595 *Regulation* of GRB2 and [FLICE2] expression by in rheumatoid synovium . Regulation CASP10 TNF 15050407 1229376 P38 mediated [caspase] activation regulates mercury induced apoptosis and p38 mediated *regulates* necrosis in these cells . Regulation CASP10 TNF 18231987 1895650 A longer treatment with DENSPM however reduced [caspase] *response* to plus CHX . Regulation CASP10 TNFSF10 15197350 1347086 Our data also show that impaired formation in the presence of TPCK is *responsible* for [caspase] inhibition . Regulation CASP12 CAPN8 11449356 836493 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Regulation CASP12 CAPN8 17567592 1778748 In contrast , pAP induced caspase-12 cleavage products were significantly decreased with PD150606 pretreatment , demonstrating that [caspase-12] activation was *dependent* . Regulation CASP12 CAPN8 18316105 1904261 Calpain inhibition reduced chromatin condensation and caspase-12 activity in the nucleus , suggesting that is *involved* in [caspase-12] activation and apoptosis . Regulation CASP12 CAPN8 19393629 2075116 Here , we report that 1,25 ( OH ) ( 2 ) D ( 3 ) induces apoptosis in mature mouse 3T3-L1 adipocytes via activation of Ca ( 2+ ) -dependent calpain and Ca ( 2+ ) *dependent* [caspase-12] . Regulation CASP12 CAPN8 19522510 2103111 This paper reports that PMFs induce apoptosis in mature mouse 3T3-L1 adipocytes via activation of Ca ( 2+ ) -dependent calpain and Ca ( 2+ ) *dependent* [caspase-12] . Regulation CASP12 CAPN8 22213319 2537651 This increase in [ Ca ( 2+ ) ] ( i ) is associated with activation of Ca ( 2+ ) -dependent µ-calpain and Ca ( 2+ ) *dependent* [caspase-12] . Regulation CASP12 EPHB2 15304372 1322289 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Regulation CASP12 EPHB2 19709398 2139174 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Regulation CASP12 EPHB2 21364665 2361260 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP12 FAS 10403377 629012 We evaluated the *effects* of antibody engagement on [caspase] activation and mitochondrial permeability , and the impact of co-stimulation by lipopolysaccharide (LPS) or granulocyte macrophage-colony stimulating factor ( GM-CSF ) on these events . Regulation CASP12 FAS 12393594 1031543 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Regulation CASP12 FAS 16120269 895994 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Regulation CASP12 FAS 16330535 1512009 costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and [caspase] activity . Regulation CASP12 MAP2K6 21364665 2361266 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP12 SPHK1 11238741 791122 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Regulation CASP12 TGM2 17003418 1618553 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Regulation CASP12 TNF 10593992 572980 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Regulation CASP12 TNF 15050407 1229386 P38 mediated [caspase] activation regulates mercury induced apoptosis and p38 mediated *regulates* necrosis in these cells . Regulation CASP12 TNF 16729970 1570514 [Caspase-12] , but not caspase-9 , was activated in *response* to , indicating that an endoplasmic reticulum ( ER ) /calcium dependent pathway may be involved . Regulation CASP12 TNF 18231987 1895660 A longer treatment with DENSPM however reduced [caspase] *response* to plus CHX . Regulation CASP12 TNFSF10 15197350 1347116 Our data also show that impaired formation in the presence of TPCK is *responsible* for [caspase] inhibition . Regulation CASP14 CAPN8 11449356 836367 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Regulation CASP14 EPHB2 15304372 1322280 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Regulation CASP14 EPHB2 19709398 2139156 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Regulation CASP14 EPHB2 21364665 2361188 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP14 FAS 10403377 629003 We evaluated the *effects* of antibody engagement on [caspase] activation and mitochondrial permeability , and the impact of co-stimulation by lipopolysaccharide (LPS) or granulocyte macrophage-colony stimulating factor ( GM-CSF ) on these events . Regulation CASP14 FAS 12393594 1031534 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Regulation CASP14 FAS 16120269 895985 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Regulation CASP14 FAS 16330535 1512000 costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and [caspase] activity . Regulation CASP14 FLG 21997417 2493681 Acting in concert with other proteases , [caspase-14] *controls* the breakdown of to free amino acids and amino acid derivatives that contribute to the hydration and UVB absorption capacity of the stratum corneum . Regulation CASP14 MAP2K6 21364665 2361194 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP14 SPHK1 11238741 791104 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Regulation CASP14 TGM2 17003418 1618490 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Regulation CASP14 TNF 10593992 572971 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Regulation CASP14 TNF 15050407 1229377 P38 mediated [caspase] activation regulates mercury induced apoptosis and p38 mediated *regulates* necrosis in these cells . Regulation CASP14 TNF 18231987 1895651 A longer treatment with DENSPM however reduced [caspase] *response* to plus CHX . Regulation CASP14 TNFSF10 15197350 1347089 Our data also show that impaired formation in the presence of TPCK is *responsible* for [caspase] inhibition . Regulation CASP16 CAPN8 11449356 836507 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Regulation CASP16 EPHB2 15304372 1322290 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Regulation CASP16 EPHB2 19709398 2139176 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Regulation CASP16 EPHB2 21364665 2361268 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP16 FAS 10403377 629013 We evaluated the *effects* of antibody engagement on [caspase] activation and mitochondrial permeability , and the impact of co-stimulation by lipopolysaccharide (LPS) or granulocyte macrophage-colony stimulating factor ( GM-CSF ) on these events . Regulation CASP16 FAS 12393594 1031544 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Regulation CASP16 FAS 16120269 895995 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Regulation CASP16 FAS 16330535 1512010 costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and [caspase] activity . Regulation CASP16 MAP2K6 21364665 2361274 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP16 SPHK1 11238741 791124 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Regulation CASP16 TGM2 17003418 1618560 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Regulation CASP16 TNF 10593992 572981 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Regulation CASP16 TNF 15050407 1229387 P38 mediated [caspase] activation regulates mercury induced apoptosis and p38 mediated *regulates* necrosis in these cells . Regulation CASP16 TNF 18231987 1895661 A longer treatment with DENSPM however reduced [caspase] *response* to plus CHX . Regulation CASP16 TNFSF10 15197350 1347119 Our data also show that impaired formation in the presence of TPCK is *responsible* for [caspase] inhibition . Regulation CASP2 CAPN8 11449356 836381 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Regulation CASP2 EPHB2 15304372 1322281 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Regulation CASP2 EPHB2 19709398 2139158 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Regulation CASP2 EPHB2 21364665 2361196 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP2 FAS 10403377 629004 We evaluated the *effects* of antibody engagement on [caspase] activation and mitochondrial permeability , and the impact of co-stimulation by lipopolysaccharide (LPS) or granulocyte macrophage-colony stimulating factor ( GM-CSF ) on these events . Regulation CASP2 FAS 12393594 1031535 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Regulation CASP2 FAS 16120269 895986 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Regulation CASP2 FAS 16330535 1512001 costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and [caspase] activity . Regulation CASP2 MAP2K6 21364665 2361202 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP2 SPHK1 11238741 791106 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Regulation CASP2 TGM2 17003418 1618497 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Regulation CASP2 TNF 10593992 572972 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Regulation CASP2 TNF 15050407 1229378 P38 mediated [caspase] activation regulates mercury induced apoptosis and p38 mediated *regulates* necrosis in these cells . Regulation CASP2 TNF 18231987 1895652 A longer treatment with DENSPM however reduced [caspase] *response* to plus CHX . Regulation CASP2 TNFSF10 15197350 1347092 Our data also show that impaired formation in the presence of TPCK is *responsible* for [caspase] inhibition . Regulation CASP3 CAPN8 11449356 836395 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Regulation CASP3 CAPN8 12453489 1020815 Interestingly , extensive degradation of [caspase-3] occurred already directly after dissection and was at least partly *dependent* . Regulation CASP3 CAPN8 15304031 1284438 PS exposure in agonist stimulated platelets was markedly reduced by inhibition of [caspase-3] activity but was not *affected* by inhibition of activity . Regulation CASP3 CAPN8 15370202 1297349 GSK-3beta a kinase regulated via PI3-kinase dependent , down-stream kinases , was responsible for regulating cyclin D1 levels in CLL cells , but neither GSK-3beta nor was *responsible* for induction of apoptosis , or activation of executioner [caspase 3] , following LY294002 treatment . Regulation CASP3 CDKN1C 22705236 2633868 Indeed , the expression of Bax , Noxa , PUMA , BNIP(3) , and cleaved [caspase-3] was not *affected* by induction . Regulation CASP3 CLU 11231633 789614 Surprisingly , the absence of had no *effect* on [caspase-3] activation , and clusterin accumulation and caspase-3 activation did not colocalize to the same cells . Regulation CASP3 EMP1 23433210 2748992 To study the *effects* of , S-band high power microwave ( S-HPM ) , and X-band high power microwave ( X-HPM ) on the Ca ( 2+ ) concentration and [caspase-3] expression in Raji cells and the relationship between Ca ( 2+ ) concentration and caspase-3 expression , and to investigate the regulatory mechanism of electromagnetic radiation damage . Regulation CASP3 EPHB2 15304372 1322282 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Regulation CASP3 EPHB2 19709398 2139160 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Regulation CASP3 EPHB2 20926686 2347556 HGF also blocked Ang II-induced [caspase-3] activation and lactate dehydrogenase release in tissue explants in an *dependent* manner . Regulation CASP3 EPHB2 21364665 2361204 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP3 EPHB2 21442306 2421899 Using specific inhibitors , we found that MAPK signaling molecules , including ERK , JNK and p38 MAPK , were important for virus release , whereas , only and p38 MAPK were *involved* in STIV induced apoptosis by modulating [caspase-3] activity . Regulation CASP3 FAS 10381641 624269 In *response* to activation LA treatment potentiated [caspase 3] activation by over 100 % . Regulation CASP3 FAS 10403377 629005 We evaluated the *effects* of antibody engagement on [caspase] activation and mitochondrial permeability , and the impact of co-stimulation by lipopolysaccharide (LPS) or granulocyte macrophage-colony stimulating factor ( GM-CSF ) on these events . Regulation CASP3 FAS 12393594 1031536 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Regulation CASP3 FAS 16120269 895987 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Regulation CASP3 FAS 16330535 1512002 costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and [caspase] activity . Regulation CASP3 FAS 8912630 395410 [CPP32] , but not ICE , was activated in *response* to stimulation . Regulation CASP3 MAP2K6 12181443 977816 LPA/S1P induced Akt activation may be involved in cell survival , because LPA and S1P treatment in HEY ovarian cancer cells results in a decrease in paclitaxel induced [caspase-3] activity in a *dependent* manner . Regulation CASP3 MAP2K6 12815279 1103444 Further , we show that may *regulate* [caspase-3] activation via the regulation of XIAP expression in these cells . Regulation CASP3 MAP2K6 21364665 2361210 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP3 SPHK1 11238741 791108 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Regulation CASP3 TGM2 17003418 1618504 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Regulation CASP3 TNF 10381360 624099 Western blot analyses confirmed that [caspase-3] was not activated in *response* to . Regulation CASP3 TNF 10593992 572973 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Regulation CASP3 TNF 15050407 1229379 P38 mediated [caspase] activation regulates mercury induced apoptosis and p38 mediated *regulates* necrosis in these cells . Regulation CASP3 TNF 15254227 1271785 Functional analyses with dominant negative mutants , small interfering RNAs , peptide inhibitors , and Fas associated death domain (FADD)- and caspase 8-deficient Jurkat T cells establish that the mitochondrion localized active caspase 8 results mainly from the FADD dependent and receptor associated death domain dependent mechanisms and that caspase 8 activation *plays* a causal role in VP16 induced [caspase 3] activation and cell death . Regulation CASP3 TNF 15978880 1446446 Ghrelin also inhibited TNFalpha induced apoptosis and suppressed [caspase-3] activation that occurs in *response* to as well as during in vitro differentiation process . Regulation CASP3 TNF 17438131 1742791 Interference by alpha-4 DND or alpha-4 siRNA increased [caspase 3/7] activation in *response* to . Regulation CASP3 TNF 18231987 1895653 A longer treatment with DENSPM however reduced [caspase] *response* to plus CHX . Regulation CASP3 TNF 18393301 1899349 The synergistic *role* of IFNgamma and in activating [caspase-3] in cholangiocytes and the decreased apoptosis following pharmacologic inhibition of caspases support a prominent role for apoptosis in the pathogenesis of experimental biliary atresia . Regulation CASP3 TNF 22471589 2601443 The apoptosis and [caspase-3] activation in *response* to hydrogen peroxide ( H2O2 ) or ( TNF a ) were assessed in the presence or absence of caspase inhibitor Z-VAD-fmk . Regulation CASP3 TNFSF10 15197350 1347095 Our data also show that impaired formation in the presence of TPCK is *responsible* for [caspase] inhibition . Regulation CASP3 TNFSF10 18006822 1827358 In addition to known genes , siRNAs targeting CDK4 , PTGS1 , ALG2 , CLCN3 , IRAK4 , and MAP3K8 altered induced [caspase-3] activation *responses* . Regulation CASP3 TNFSF10 19945431 2198961 Caspase 8 or [caspase 3] activities in *response* to were greatly incremented in TOPK depleted cells . Regulation CASP4 CAPN8 11449356 836409 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Regulation CASP4 EPHB2 15304372 1322283 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Regulation CASP4 EPHB2 19709398 2139162 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Regulation CASP4 EPHB2 21364665 2361212 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP4 FAS 10403377 629006 We evaluated the *effects* of antibody engagement on [caspase] activation and mitochondrial permeability , and the impact of co-stimulation by lipopolysaccharide (LPS) or granulocyte macrophage-colony stimulating factor ( GM-CSF ) on these events . Regulation CASP4 FAS 12393594 1031537 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Regulation CASP4 FAS 16120269 895988 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Regulation CASP4 FAS 16330535 1512003 costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and [caspase] activity . Regulation CASP4 MAP2K6 21364665 2361218 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP4 SPHK1 11238741 791110 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Regulation CASP4 TGM2 17003418 1618511 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Regulation CASP4 TNF 10593992 572974 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Regulation CASP4 TNF 15050407 1229380 P38 mediated [caspase] activation regulates mercury induced apoptosis and p38 mediated *regulates* necrosis in these cells . Regulation CASP4 TNF 18231987 1895654 A longer treatment with DENSPM however reduced [caspase] *response* to plus CHX . Regulation CASP4 TNFSF10 15197350 1347098 Our data also show that impaired formation in the presence of TPCK is *responsible* for [caspase] inhibition . Regulation CASP5 CAPN8 11449356 836423 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Regulation CASP5 EPHB2 15304372 1322284 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Regulation CASP5 EPHB2 19709398 2139164 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Regulation CASP5 EPHB2 21364665 2361220 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP5 FAS 10403377 629007 We evaluated the *effects* of antibody engagement on [caspase] activation and mitochondrial permeability , and the impact of co-stimulation by lipopolysaccharide (LPS) or granulocyte macrophage-colony stimulating factor ( GM-CSF ) on these events . Regulation CASP5 FAS 12393594 1031538 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Regulation CASP5 FAS 16120269 895989 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Regulation CASP5 FAS 16330535 1512004 costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and [caspase] activity . Regulation CASP5 MAP2K6 21364665 2361226 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP5 SPHK1 11238741 791112 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Regulation CASP5 TGM2 17003418 1618518 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Regulation CASP5 TNF 10593992 572975 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Regulation CASP5 TNF 15050407 1229381 P38 mediated [caspase] activation regulates mercury induced apoptosis and p38 mediated *regulates* necrosis in these cells . Regulation CASP5 TNF 18231987 1895655 A longer treatment with DENSPM however reduced [caspase] *response* to plus CHX . Regulation CASP5 TNFSF10 15197350 1347101 Our data also show that impaired formation in the presence of TPCK is *responsible* for [caspase] inhibition . Regulation CASP6 CAPN8 11449356 836437 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Regulation CASP6 EPHB2 15304372 1322285 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Regulation CASP6 EPHB2 19709398 2139166 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Regulation CASP6 EPHB2 21364665 2361228 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP6 FAS 10403377 629008 We evaluated the *effects* of antibody engagement on [caspase] activation and mitochondrial permeability , and the impact of co-stimulation by lipopolysaccharide (LPS) or granulocyte macrophage-colony stimulating factor ( GM-CSF ) on these events . Regulation CASP6 FAS 12393594 1031539 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Regulation CASP6 FAS 16120269 895990 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Regulation CASP6 FAS 16330535 1512005 costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and [caspase] activity . Regulation CASP6 MAP2K6 21364665 2361234 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP6 SPHK1 11238741 791114 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Regulation CASP6 TGM2 17003418 1618525 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Regulation CASP6 TNF 10593992 572976 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Regulation CASP6 TNF 15050407 1229382 P38 mediated [caspase] activation regulates mercury induced apoptosis and p38 mediated *regulates* necrosis in these cells . Regulation CASP6 TNF 18231987 1895656 A longer treatment with DENSPM however reduced [caspase] *response* to plus CHX . Regulation CASP6 TNFSF10 15197350 1347104 Our data also show that impaired formation in the presence of TPCK is *responsible* for [caspase] inhibition . Regulation CASP7 CAPN8 11449356 836451 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Regulation CASP7 EPHB2 15304372 1322286 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Regulation CASP7 EPHB2 19709398 2139168 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Regulation CASP7 EPHB2 21364665 2361236 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP7 F3 21472232 2361561 VIIa *regulates* interleukin-8 , tissue factor and [caspase-7] expression in SW620 cells through protease activated receptor-2 activation . Regulation CASP7 FAS 10403377 629009 We evaluated the *effects* of antibody engagement on [caspase] activation and mitochondrial permeability , and the impact of co-stimulation by lipopolysaccharide (LPS) or granulocyte macrophage-colony stimulating factor ( GM-CSF ) on these events . Regulation CASP7 FAS 12393594 1031540 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Regulation CASP7 FAS 16120269 895991 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Regulation CASP7 FAS 16330535 1512006 costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and [caspase] activity . Regulation CASP7 MAP2K6 21364665 2361242 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP7 SPHK1 11238741 791116 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Regulation CASP7 TGM2 17003418 1618532 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Regulation CASP7 TNF 10593992 572977 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Regulation CASP7 TNF 15050407 1229383 P38 mediated [caspase] activation regulates mercury induced apoptosis and p38 mediated *regulates* necrosis in these cells . Regulation CASP7 TNF 17438131 1742792 Interference by alpha-4 DND or alpha-4 siRNA increased [caspase 3/7] activation in *response* to . Regulation CASP7 TNF 18231987 1895657 A longer treatment with DENSPM however reduced [caspase] *response* to plus CHX . Regulation CASP7 TNFSF10 15197350 1347107 Our data also show that impaired formation in the presence of TPCK is *responsible* for [caspase] inhibition . Regulation CASP8 CAPN8 11449356 836465 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Regulation CASP8 EPHB2 12122017 984990 Head involution defective ( Hid ) -triggered apoptosis requires [caspase-8] but not FADD ( Fas associated death domain ) and is *regulated* by in mammalian cells . Regulation CASP8 EPHB2 15304372 1322287 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Regulation CASP8 EPHB2 19709398 2139170 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Regulation CASP8 EPHB2 20404718 2246106 Since sustained ERK activation can activate caspase-8 in some cell types , we studied the *role* of in Vpr induced [caspase-8] activation . Regulation CASP8 EPHB2 21364665 2361244 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP8 FAS 10196099 604262 DISC formation is the first essential step of signaling and *results* in activation of [caspase-8] starting a signaling cascade that leads to apoptosis . Regulation CASP8 FAS 10403377 629010 We evaluated the *effects* of antibody engagement on [caspase] activation and mitochondrial permeability , and the impact of co-stimulation by lipopolysaccharide (LPS) or granulocyte macrophage-colony stimulating factor ( GM-CSF ) on these events . Regulation CASP8 FAS 10933582 720324 Bid is a novel pro-apoptosis Bcl-2 family protein that is activated by [Caspase 8] in *response* to death receptor activation . Regulation CASP8 FAS 11032168 740244 Bid is a novel pro-apoptosis Bcl-2 family protein that is activated by [caspase 8] in *response* to death receptor signals . Regulation CASP8 FAS 11222383 787555 Activation of [caspase-8] in drug induced apoptosis of B-lymphoid cells is *independent* of receptor-ligand interaction and occurs downstream of caspase-3 . Regulation CASP8 FAS 12393594 1031541 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Regulation CASP8 FAS 16018969 1435073 In the present study , we investigated the *role* of signaling in [caspase 8] activation induced by fast neutrons irradiation in these cells . Regulation CASP8 FAS 16112422 1448659 Gemcitabine treatment of Colo357 cells increased CD95 surface expression , raising the possibility of the *involvement* of in gemcitabine mediated [caspase-8] activation . Regulation CASP8 FAS 16112422 1448663 These observations argue against a *role* of in gemcitabine induced [caspase-8] activation and reveal that the anti-apoptotic function of DN-FADD differs from caspase-8 inhibition in Colo357 cells . Regulation CASP8 FAS 16120269 895992 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Regulation CASP8 FAS 16330535 1512007 costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and [caspase] activity . Regulation CASP8 FAS 16646083 1563154 Thus , A20 expression blocks OxLDL mediated apoptosis in murine RAW264.7 macrophages through disrupting *dependent* activation of [caspase-8] and the mitochondria pathway . Regulation CASP8 FAS 18045865 1852404 It is concluded that a rapid [caspase 8] activation in *response* to signals to intracellularly stored CD95 , which becomes activated and targeted to the plasma membrane . Regulation CASP8 FAS 18615109 1972358 We have shown that death of these precursors involved the *dependent* activation of [caspase-8] . Regulation CASP8 FAS 19521777 2098410 BEFV infection of BHK-21 cells results in the *dependent* activation of [caspase 8] and cleavage of Bid . Regulation CASP8 FAS 21903094 2491821 Further , we studied the potential *involvement* of the and tumor necrosis factor receptor (TNFR) mediated signaling in the activation of [caspase-8] by c-Myc. Blocking of the function of these death receptors by neutralizing antibodies against Fas ligand and TNF-a did not prevent the processing of caspase-8 or cell death . Regulation CASP8 FAS 9468507 486061 Thus , at least in some cells , [caspase-8] signaling in *response* to or TNFR1 stimulation is regulated by a Bcl-xL-inhibitable step . Regulation CASP8 JAG1 21714972 2465885 Moreover , the lack of caspase-8 activation in AGS patients indicates a possible selective impairment of caspase-8 cleavage suggesting that *plays* a specific role in the regulation of [caspase-8] activation . Regulation CASP8 MAP2K6 21364665 2361250 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP8 SPHK1 11238741 791118 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Regulation CASP8 TGM2 17003418 1618539 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Regulation CASP8 TNF 10442631 635704 Based on cleavage of the FLICE substrate PARP , this inhibitory effect was paralleled by a threefold decline in [FLICE] activation in *response* to . Regulation CASP8 TNF 10593992 572978 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Regulation CASP8 TNF 15050407 1229384 P38 mediated [caspase] activation regulates mercury induced apoptosis and p38 mediated *regulates* necrosis in these cells . Regulation CASP8 TNF 15727562 1416780 In time course analyses , cleavage and activation of [caspase 8] in *response* to were not affected by MitoVit E , whereas the activation of caspase 3 was significantly increased . Regulation CASP8 TNF 18231987 1895658 A longer treatment with DENSPM however reduced [caspase] *response* to plus CHX . Regulation CASP8 TNF 20564232 2290302 Immunoprecipitation studies revealed associations of NM IIB with clathrin , FADD , and [caspase 8] in *response* to suggesting a role for NM IIB in TNFR1 endocytosis and the formation of the death inducing signaling complex (DISC) . Regulation CASP8 TNF 21903094 2491820 Further , we studied the potential *involvement* of the Fas- and mediated signaling in the activation of [caspase-8] by c-Myc. Blocking of the function of these death receptors by neutralizing antibodies against Fas ligand and TNF-a did not prevent the processing of caspase-8 or cell death . Regulation CASP8 TNF 23151904 2723064 CF31 inhibition of TNF-a activation of AKT also results in *dependent* activation of [caspase-8] and apoptosis . Regulation CASP8 TNFSF10 11221844 787392 In *response* to , [caspase-8] , an initiator caspase in death receptor mediated apoptosis , was activated within 1 h in association with Bid cleavage , cytochrome c release , caspase-3 activation , and DNA fragmentation factor 45 cleavage . Regulation CASP8 TNFSF10 15197350 1347110 Our data also show that impaired formation in the presence of TPCK is *responsible* for [caspase] inhibition . Regulation CASP9 CAPN8 11449356 836479 The *role* of in [caspase] activation during etoposide induced apoptosis in T cells . Regulation CASP9 EMP1 24338711 2926798 *regulates* [caspase-9] and VEGFC expression and suppresses prostate cancer cell proliferation and invasion . Regulation CASP9 EPHB2 15304372 1322288 Thus the Akt mediated phosphorylation pathway , signaling , and the antiapoptotic Bcl-2 proteins distinctly *regulate* [caspase] activation during oxidant injury to RTE . Regulation CASP9 EPHB2 19709398 2139172 Since and cytochrome c are differentially *involved* in [caspase] signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion , we considered if DOR activation protects the ischemic brain by attenuating oxidative injury . Regulation CASP9 EPHB2 21364665 2361252 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP9 FAS 10403377 629011 We evaluated the *effects* of antibody engagement on [caspase] activation and mitochondrial permeability , and the impact of co-stimulation by lipopolysaccharide (LPS) or granulocyte macrophage-colony stimulating factor ( GM-CSF ) on these events . Regulation CASP9 FAS 12393594 1031542 These results suggest that LF 15-0195 sensitizes T cells to AICD by increasing [caspase] activation at the DISC level in *response* to engagement . Regulation CASP9 FAS 16120269 895993 Caspase activation took place predominantly in the cytosol in *response* to ligation , but staurosporine treatment led to [caspase] activation in both cytosol and mitochondria . Regulation CASP9 FAS 16330535 1512008 costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and [caspase] activity . Regulation CASP9 MAP2K6 12792650 1100906 [Caspase-9] is phosphorylated at Thr 125 , a conserved MAPK consensus site targeted by ERK2 in vitro , in a *dependent* manner in cells stimulated with epidermal growth factor (EGF) or 12-O-tetradecanoylphorbol-13-acetate ( TPA ) . Regulation CASP9 MAP2K6 21364665 2361258 *dependent* multiple [caspase] activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death . Regulation CASP9 SPHK1 11238741 791120 expression *regulates* apoptosis and [caspase] activation in PC12 cells . Regulation CASP9 TGM2 17003418 1618546 This study evaluates the *role* of in regulating tumor necrosis factor (TNF) receptor clustering as well as [caspase] activation in UVB induced apoptosis in human corneal epithelial cells . Regulation CASP9 TNF 10593992 572979 These results indicate that [caspase] activation in *response* to has anti-necrotic as well as pro-apoptotic effects and extend our understanding of the biological role of these proteases . Regulation CASP9 TNF 11836241 929144 Cytochrome c was released from mitochondria , and [caspase-9] was activated in Bax- or Bak-deficient cells in *response* to but not in cells deficient in both . Regulation CASP9 TNF 12869386 1149974 SP-600125 , a specific inhibitor of JNK activation , prevented cytochrome c release from mitochondria , JNK activation , DNA fragmentation , and [caspase-9] activation in *response* to . Regulation CASP9 TNF 15050407 1229385 P38 mediated [caspase] activation regulates mercury induced apoptosis and p38 mediated *regulates* necrosis in these cells . Regulation CASP9 TNF 16263807 1539300 However , pro-caspase-8 levels were low , and [caspase-9] was also activated in *response* to , characteristic of what have been termed type II cells . Regulation CASP9 TNF 16729970 1570513 Caspase-12 , but not [caspase-9] , was activated in *response* to , indicating that an endoplasmic reticulum ( ER ) /calcium dependent pathway may be involved . Regulation CASP9 TNF 16966373 1633432 By using a large panel of genetically modified murine embryonic fibroblasts , we show here that , in *response* to , caspase-8 cleaves and activates [caspase-9] in an apoptosome independent manner . Regulation CASP9 TNF 18231987 1895659 A longer treatment with DENSPM however reduced [caspase] *response* to plus CHX . Regulation CASP9 TNFSF10 15197350 1347113 Our data also show that impaired formation in the presence of TPCK is *responsible* for [caspase] inhibition . Regulation CASQ2 EDN2 20529095 2271413 *Role* of in the effects of isoprenaline on potassium currents and [calsequestrin 2] expression in the heart . Regulation CASR TNF 11389006 821971 This study assessed whether *plays* a role in phenotypic expression of [HHC] . Regulation CAST CAPN8 11745202 887590 The treatment of cultured cells with hydrogen peroxide induced both *dependent* cleavage of merlin and reduction of an intrinsic calpain inhibitor [calpastatin] . Regulation CAST CAPN8 1328642 197924 These findings and the existence of PEDST sequences suggest that the JFP is normally degraded by in vivo and that degradation is *regulated* by [calpastatin] and calmodulin . Regulation CAST CAPN8 1388013 196343 Under identical conditions , in red cells of normotensive rats , activation is efficiently *controlled* by the high levels of [calpastatin] activity , and a progressive increase in proteinase activity can only be observed in parallel with a decrease in the level of calpastatin . Regulation CAST CAPN8 17881114 1858363 Besides its regulation by calcium , activity is tightly *controlled* by [calpastatin] , the specific endogenous inhibitor , binding to phospholipids , autoproteolysis and phosphorylation . Regulation CAST CAPN8 1829675 161406 Cyclin proteolysis at micromolar free Ca2+ , is not inhibited by [calpastatin] , and therefore does not *involve* . Regulation CAST CAPN8 18519038 1922541 The activity of is *controlled* by the free intracellular calcium level and by the protein 's intrinsically disordered endogenous inhibitor , [calpastatin] , mediated by short conserved segments : subdomains A-C . Regulation CAT TNF 7628389 316418 PMA , a known activator of PKC , and had a similar inhibitory *effect* on P450c17 expression , testosterone production , and [Cyp17-CAT] activity . Regulation CAV1 GPR115 16997880 1628690 These data support our hypothesis that increased Po ( 2 ) at birth promotes dissociation of caveolin-1 and NOS-3 , with an increase in their activities , and that PKC and an oxygen-sensitive cell surface *regulate* [caveolin-1] and NOS-3 interactions in fetal and neonatal lung MVECs . Regulation CAV1 GPR132 16997880 1628679 These data support our hypothesis that increased Po ( 2 ) at birth promotes dissociation of caveolin-1 and NOS-3 , with an increase in their activities , and that PKC and an oxygen-sensitive cell surface *regulate* [caveolin-1] and NOS-3 interactions in fetal and neonatal lung MVECs . Regulation CAV1 GPR87 16997880 1628759 These data support our hypothesis that increased Po ( 2 ) at birth promotes dissociation of caveolin-1 and NOS-3 , with an increase in their activities , and that PKC and an oxygen-sensitive cell surface *regulate* [caveolin-1] and NOS-3 interactions in fetal and neonatal lung MVECs . Regulation CAV1 NR2F1 19008385 1991405 These findings indicate that the [CAV] promoter activity can be *affected* directly or indirectly by and deltaEF1 . Regulation CAV1 PECAM1 24077950 2874218 Lack of did not *affect* NOX2 activation machinery or the [caveolin-1] expression or caveolae number in the pulmonary endothelium . Regulation CAV1 TNF 18207479 1876659 *Regulation* of [caveolin-1] expression , nitric oxide production and tissue injury by following ozone inhalation . Regulation CAV1 TNF 23383114 2739512 Rac1 inhibitors significantly abolished this barrier-protective effect induced by down-regulation of [caveolin-1] in *response* to in RPMVECs . Regulation CBFA2T2 PECAM1 20723025 2357016 To investigate the possibility that *regulates* the formation of the [Gab1-p85] signaling complexes , and the potential effect of such interactions on GPVI mediated platelet activation in platelets . Regulation CBFA2T2 RAB31 18974049 2001249 Conversely , caspase 8-dependent GTP loading of Rab5 is overcome by increased expression of [p85alpha] in a *dependent* manner . Regulation CBY1 NES 19940019 2190518 Importantly , the NLS- and *dependent* shuttling of [Cby] modulates the dynamic intracellular localization of beta-catenin . Regulation CBY3 NES 19940019 2190519 Importantly , the NLS- and *dependent* shuttling of [Cby] modulates the dynamic intracellular localization of beta-catenin . Regulation CCK SYNM 6473170 41815 The data suggest that the may *play* a role in [CCK] induced satiety . Regulation CCL1 TNF 19302817 2064274 DNA binding activity of NF-kappaB , a well-known molecular effector of TNFalpha , was moreover activated by Lp(a) in a *dependent* manner and the use of the NF-kappaB inhibitor Bay 11-7082 blocked Lp(a) triggered [CCL1] induction . Regulation CCL11 TNF 16755001 1571586 Differential *regulation* of [eotaxin-1/CCL11] and eotaxin-3/CCL26 production by the and IL-4 stimulated human lung fibroblast . Regulation CCL13 TNF 23007802 2837656 Interestingly , [CCL13] expression was positively *regulated* by ( TNF-a ) . Regulation CCL17 CCL22 19715610 2133528 Previously , we have demonstrated the selective upregulation of the macrophage derived chemokine and the thymus activation *regulated* chemokine [CCL17] among chemokines , in a rat model of radiation pneumonitis/pulmonary fibrosis and preliminarily observed an increase in bronchoalveolar (BAL) fluid CCL22 levels of IPF patients . Regulation CCL17 CCR4 18765730 1975687 CASP induced sepsis led to a massive downregulation of CCR4 in lymphoid and nonlymphoid tissues , whereas the expression of [CCL17] and CCL22 was *independent* of the presence of . Regulation CCL17 CD40 21054781 2469436 In contrast , LC-like cells released [CCL17] in *response* to ligation , irrespective of a prior treatment with TSLP . Regulation CCL17 DTX1 24489574 2884822 Moreover , the production of CXCL10 and CXCL11 from M2 macrophages was significantly increased by DTX with RS though there was no *effect* of with RS on the production of CCL5 and [CCL17] . Regulation CCL17 DTX2 24489574 2884819 Moreover , the production of CXCL10 and CXCL11 from M2 macrophages was significantly increased by DTX with RS though there was no *effect* of with RS on the production of CCL5 and [CCL17] . Regulation CCL17 DTX3 24489574 2884820 Moreover , the production of CXCL10 and CXCL11 from M2 macrophages was significantly increased by DTX with RS though there was no *effect* of with RS on the production of CCL5 and [CCL17] . Regulation CCL17 DTX4 24489574 2884821 Moreover , the production of CXCL10 and CXCL11 from M2 macrophages was significantly increased by DTX with RS though there was no *effect* of with RS on the production of CCL5 and [CCL17] . Regulation CCL17 HMOX1 21843792 2468514 Psidium guajava extract inhibits thymus and activation *regulated* chemokine ( [TARC/CCL17] ) production in human keratinocytes by inducing and blocking NF-?B and STAT1 activation . Regulation CCL17 IFNG 16117790 1449201 Stimulation with tumor necrosis factor (TNF)alpha and synergistically induced thymus- and activation *regulated* chemokine ( TARC ) [/CCL17] production from HaCaT keratinocytes ( KC ) . Regulation CCL17 IL13 19841166 2160161 We report here that IL-33 changed the quiescent phenotype of alveolar macrophages toward an AAM phenotype that expressed mannose receptor , IL-4Ralpha , and produced high levels of CCL24 and [CCL17] in an *dependent* manner during IL-33 induced airway inflammation . Regulation CCL17 IL17A 17101734 1650852 Mechanistically , down modulated eosinophil-chemokine eotaxin ( CCL11 ) and thymus- and activation *regulated* [chemokine/CCL17] ( TARC ) in lungs in vivo and ex vivo upon antigen restimulation . Regulation CCL17 POLDIP2 20837364 2368513 The present results suggest that TNF-a induced [CCL17] mRNA transcription in CPEK is positively *regulated* by but negatively controlled by ERK . Regulation CCL17 STAT1 21843792 2468513 Psidium guajava extract inhibits thymus and activation *regulated* chemokine ( [TARC/CCL17] ) production in human keratinocytes by inducing heme oxygenase-1 and blocking NF-?B and activation . Regulation CCL17 STAT6 15585884 1345869 Unexpectedly , expression of only three chemokines , CCL11 , [CCL17] , and CCL22 , was *dependent* , and many of the identified chemokines were overexpressed in STAT6-deficient mice , providing an explanation for the enhanced neutrophilic inflammation seen in these mice . Regulation CCL17 STAT6 20393449 2240469 The following study investigates the *role* of the transcriptional activator in IL-4 dependant gene expression of [CCL17] in a Burkitt lymphoma cell line ( Namalwa ) . Regulation CCL17 TGFB1 12413771 1010986 mediated *regulation* of thymus and activation regulated chemokine ( [TARC/CCL17] ) synthesis and secretion by HaCaT cells co-stimulated with TNF-alpha and IFN-gamma . Regulation CCL17 TGFB1 12413771 1010987 In this paper , the *effects* of on the expression of [TARC/CCL17] were examined in HaCaT cells , a human keratinocytes (KCs) cell line , co-stimulated with TNF-alpha and IFN-gamma . Regulation CCL17 TLR1 18557811 1972027 Moreover , we investigated the *effects* of cytokines and ligands on the production of [CCL17] by human gingival fibroblasts ( HGFs ) . Regulation CCL17 TLR1 18557811 1972043 These results suggest that the CCL17 produced by HGFs may be involved in the migration of Th2 cells into inflamed tissues , and provide evidence that [CCL17] production is *controlled* by cytokines and ligands in periodontal disease . Regulation CCL17 TLR10 18557811 1972035 Moreover , we investigated the *effects* of cytokines and ligands on the production of [CCL17] by human gingival fibroblasts ( HGFs ) . Regulation CCL17 TLR10 18557811 1972051 These results suggest that the CCL17 produced by HGFs may be involved in the migration of Th2 cells into inflamed tissues , and provide evidence that [CCL17] production is *controlled* by cytokines and ligands in periodontal disease . Regulation CCL17 TLR2 18557811 1972028 Moreover , we investigated the *effects* of cytokines and ligands on the production of [CCL17] by human gingival fibroblasts ( HGFs ) . Regulation CCL17 TLR2 18557811 1972044 These results suggest that the CCL17 produced by HGFs may be involved in the migration of Th2 cells into inflamed tissues , and provide evidence that [CCL17] production is *controlled* by cytokines and ligands in periodontal disease . Regulation CCL17 TLR3 18557811 1972029 Moreover , we investigated the *effects* of cytokines and ligands on the production of [CCL17] by human gingival fibroblasts ( HGFs ) . Regulation CCL17 TLR3 18557811 1972045 These results suggest that the CCL17 produced by HGFs may be involved in the migration of Th2 cells into inflamed tissues , and provide evidence that [CCL17] production is *controlled* by cytokines and ligands in periodontal disease . Regulation CCL17 TLR4 18557811 1972030 Moreover , we investigated the *effects* of cytokines and ligands on the production of [CCL17] by human gingival fibroblasts ( HGFs ) . Regulation CCL17 TLR4 18557811 1972046 These results suggest that the CCL17 produced by HGFs may be involved in the migration of Th2 cells into inflamed tissues , and provide evidence that [CCL17] production is *controlled* by cytokines and ligands in periodontal disease . Regulation CCL17 TLR5 18557811 1972031 Moreover , we investigated the *effects* of cytokines and ligands on the production of [CCL17] by human gingival fibroblasts ( HGFs ) . Regulation CCL17 TLR5 18557811 1972047 These results suggest that the CCL17 produced by HGFs may be involved in the migration of Th2 cells into inflamed tissues , and provide evidence that [CCL17] production is *controlled* by cytokines and ligands in periodontal disease . Regulation CCL17 TLR6 18557811 1972036 Moreover , we investigated the *effects* of cytokines and ligands on the production of [CCL17] by human gingival fibroblasts ( HGFs ) . Regulation CCL17 TLR6 18557811 1972052 These results suggest that the CCL17 produced by HGFs may be involved in the migration of Th2 cells into inflamed tissues , and provide evidence that [CCL17] production is *controlled* by cytokines and ligands in periodontal disease . Regulation CCL17 TLR7 18557811 1972032 Moreover , we investigated the *effects* of cytokines and ligands on the production of [CCL17] by human gingival fibroblasts ( HGFs ) . Regulation CCL17 TLR7 18557811 1972048 These results suggest that the CCL17 produced by HGFs may be involved in the migration of Th2 cells into inflamed tissues , and provide evidence that [CCL17] production is *controlled* by cytokines and ligands in periodontal disease . Regulation CCL17 TLR8 18557811 1972033 Moreover , we investigated the *effects* of cytokines and ligands on the production of [CCL17] by human gingival fibroblasts ( HGFs ) . Regulation CCL17 TLR8 18557811 1972049 These results suggest that the CCL17 produced by HGFs may be involved in the migration of Th2 cells into inflamed tissues , and provide evidence that [CCL17] production is *controlled* by cytokines and ligands in periodontal disease . Regulation CCL17 TLR9 18557811 1972034 Moreover , we investigated the *effects* of cytokines and ligands on the production of [CCL17] by human gingival fibroblasts ( HGFs ) . Regulation CCL17 TLR9 18557811 1972050 These results suggest that the CCL17 produced by HGFs may be involved in the migration of Th2 cells into inflamed tissues , and provide evidence that [CCL17] production is *controlled* by cytokines and ligands in periodontal disease . Regulation CCL17 TNF 16117790 1449200 Stimulation with and interferon (IFN)gamma synergistically induced thymus- and activation *regulated* chemokine ( TARC ) [/CCL17] production from HaCaT keratinocytes ( KC ) . Regulation CCL17 TSLP 23576878 2768505 We report here that beyond simply expressing the receptor , epithelial cells are capable of dynamically regulating TSLPR in response to the same inflammatory cues that drive the production of TSLP , and that epithelial cells produce [chemokine C-C motif ligand 17] , a T helper type 2-associated chemokine , in *response* to stimulation with . Regulation CCL2 CAPN8 9633934 513204 The effects of norLeu were due to its inhibition of the proteasome rather than calpain , because other inhibitors had no *effect* on [MCP-1] expression . Regulation CCL2 CD14 23508573 2787824 HMGB1 induces the release of [monocyte chemotactic protein 1 (MCP-1)] , interferon gamma induced protein 10 ( IP-10 ) and macrophage inflammatory protein 1a ( MIP-1a ) in a TLR4- and *dependent* manner . Regulation CCL2 CTGF 16204411 1517628 The direct *effect* of ( 20 , 200 , and 400 ng/ml ) on IL-8 and [MCP-1] was assessed at 24- , 48- , and 72-h time points and no stimulation was observed . Regulation CCL2 CTGF 16408113 1513391 The present studies investigate the regulatory *role* of in the production of fractalkine , [monocyte chemoattractant protein-1] ( MCP-1 ) , and RANTES ( regulated upon activation , normal T cell expressed and secreted ) in cultured mesangial cells of rats , and the modulatory effects of lipoxin A ( 4 ) ( LXA ( 4 ) ) on actions of CTGF . Regulation CCL2 CTGF 19378419 2007963 This study investigates the regulatory *role* of on production of fractalkine , [monocyte-chemoattractant protein-1] ( MCP-1 ) and regulated on activation , normal T cell expressed and secreted ( RANTES ) in human mesangial cells , and explore the mechanisms of CTGF action . Regulation CCL2 CTGF 23274856 2758051 However , the *effect* of on [MCP-1] expression and monocyte migration is largely unknown . Regulation CCL2 EPHB2 12517735 1070989 In conclusion , these findings indicate that signaling is *involved* in BSA induced [MCP-1] expression in mProx cells . Regulation CCL2 EPHB2 12854631 1110242 We conclude that p38 MAPK , JNK kinase , and NF-kappaB are *involved* in the IL-1beta induced eotaxin , [MCP-1] , and MCP-3 expression and release in HASMC . Regulation CCL2 EPHB2 15016614 1257083 In contrast , inhibition of did not *affect* the upregulation of [CCL2] induced by the two cytokines . Regulation CCL2 EPHB2 15100369 1239793 mRNA expression of [MCP-1] was abolished by NF-kappaB inhibition , but were not *affected* by the inhibition of , JNK , or p38 . Regulation CCL2 EPHB2 19125410 2053749 Reciprocal *regulation* of ATPgammaS induced [monocyte chemoattractant protein-1] production by and p38 MAP kinases in rat corticostriatal slice cultures . Regulation CCL2 EPHB2 19125410 2053750 Similar *effects* of and p38 MAP kinase inhibitors on [MCP-1] production were observed in the slices stimulated by ATP and BzATP . Regulation CCL2 EPHB2 19125410 2053753 These results demonstrate that astrocytic [MCP-1] production induced by P2 purinoceptor stimulation is reciprocally *regulated* by and p38 MAP kinases in the organotypic slice cultures . Regulation CCL2 FAS 12946945 1143214 and Fas associated death domain protein *regulate* [monocyte chemoattractant protein-1] expression by human smooth muscle cells through caspase- and calpain dependent release of interleukin-1alpha . Regulation CCL2 FAS 20926603 2375720 In contrast , IL-6 , [MCP-1] and RANTES were not *regulated* by . Regulation CCL2 IL1B 10880246 709112 On the other hand , [JE/MCP-1] mRNA expression was detected only in non-parenchymal cells in *response* to TNF-alpha and , but not in response to IFN-gamma . Regulation CCL2 IL1B 11673556 872885 On the other hand , [CCL2] , CCL5 , and CXCL12 were expressed on RA FLS , and their production was *regulated* by TNF-alpha , , and TGF-beta1 . Regulation CCL2 IL1B 11748220 905527 Antisense oligonucleotide suppression of zfm1 protein synthesis mimicked the stimulatory *effects* of and TNF alpha on SMC proliferation and expression of the chemokine [MCP-1] and the vascular cell adhesion molecule-1 . Regulation CCL2 IL1B 12840897 581660 *Effect* of and TNF-alpha on the expression of [monocyte chemotactic protein-1] in endometriotic cells . Regulation CCL2 IL1B 15191916 1280932 Molecular *regulation* of interleukin-13 and [monocyte chemoattractant protein-1] expression in human mast cells by . Regulation CCL2 IL1B 15298980 1322232 Independent *regulation* of prostaglandins and [monocyte chemoattractant protein-1] by and hCG in human endometrial cells . Regulation CCL2 IL1B 16055671 1466210 Both differentiated and dedifferentiated type II cells secreted MIP-2 , [MCP-1] , and CINC-2 in *response* to a cytokine mixture of IL-1beta , TNF-alpha , and IFN-gamma or to alone . Regulation CCL2 IL1B 16085045 1443031 Levels of IR [MCP-1] increased in myometrial cultures in *response* to . Regulation CCL2 IL1B 16239643 1508322 Both cell phenotypes secreted MIP-2 and [MCP-1] in *response* to or lipopolysaccharide , but there was no priming or synergy with ozone . Regulation CCL2 IL1B 19124762 2019595 Priming of the cells with ER stress inducers ( tunicamycin , thapsigargin , A23187 , and AB5 subtilase cytotoxin ) caused blunted induction of [MCP-1] in *response* to TNF-alpha , , macrophage derived factors , or bystander macrophages . Regulation CCL2 IL1B 19426980 2157198 [MCP-1] expression was *regulated* by and TNF-alpha and cytokine induced PREB expression . Regulation CCL2 IL1B 19439823 2090485 Furthermore , these data suggested that [MCP-1] was *regulated* by TNF-alpha and , and activated by both cytokines and biomaterials . Regulation CCL2 IL1B 7942160 276324 The *effects* of , tumor necrosis factor alpha (TNF-alpha) , interleukin-6 (IL-6) , transforming growth factor beta ( TGF-beta ) , platelet derived growth factor ( PDGF-BB ) , parathyroid hormone (PTH) , and 1,25 ( OH ) 2D3 on [MCP-1] expression in human osteoblastic cells were compared . Regulation CCL2 IL1B 8831705 385818 Compared to mock transfectants , the vector cells showed blunted expression of gelatinase B , stromelysin and [monocyte chemoattractant protein-1] in *response* to . Regulation CCL2 IL1B 9376623 465521 MKN28 cells were found to secrete [MCP-1] in *response* to or TNFalpha in a dose- and time dependent manner . Regulation CCL2 IL1B 9536945 497505 Caco-2 cells , with features more typical of villus absorptive cells , were relatively poor secretors of alpha chemokines but secreted high levels of [MCP-1] in *response* to . Regulation CCL2 IL1B 9831176 551451 and interferon-gamma differentially *regulate* release of [monocyte chemotactic protein-1] and interleukin-8 by human bronchial epithelial cells . Regulation CCL2 IL1B 9831176 551468 Our results indicate that IFN-gamma and differentially *regulate* the [MCP-1] and IL-8 release by human bronchial epithelial cells . Regulation CCL2 MAP2K6 22361885 2561485 In addition , we revealed that JNK and are *involved* in flagellin induced [MCP-1] expression in E1 cells . Regulation CCL2 MIP 11851360 913227 Chemokine expression in myocardial ischemia : *dependent* [MCP-1] expression protects cardiomyocytes from cell death . Regulation CCL2 MIP 16387335 1567074 LTA produced a dose related increase in early pulmonary inflammation , which was characterized by ( 1 ) influx of polymorphonuclear neutrophils ( PMNs ) and ( 2 ) induction of interleukin (IL)-6 , tumor necrosis factor (TNF)-alpha , , but no *effect* on monocyte chemoattractant protein [(MCP)-1/CCL2] at 24 h after instillation . Regulation CCL2 PLAU 21786025 2476561 Based on above results , Ang II may induced cerebral aneurysm , ischemia/infarction on brain through RAS system by down regulating the mRNA levels of MMP 2 , , PAI , PPAR-A , MCSF1 and up *regulating* tPA and [MCP-1] and ß carotene attenuates the disease condition and bring down to normal expression levels of above genes . Regulation CCL2 RNF150 20648642 2292927 Using a panel of kinase inhibitors , we demonstrated that NOV action on [CCL2] and CXCL1 production *involved* a and a Rho/qROCK/p38/NF-kappaB pathway , respectively . Regulation CCL2 SMN2 22669976 2632888 *dependent* induction of [CCL2] and IGF1 mRNAs resulted in increased intracellular levels and secretion of the respective protein products . Regulation CCL2 SPHK1 15191888 1295218 We further investigated the *role* of in TNF-alpha induced expression of inflammatory genes , such as [monocyte chemoattractant protein-1] ( MCP-1 ) and VCAM-1 by using small interfering RNA ( siRNA ) specifically for SphK1 . Regulation CCL2 SPHK1 18178871 1889965 but not SphK2 *plays* a critical role in IgE/Ag induced degranulation , migration toward antigen , and [CCL2] secretion from hMCs , as determined by specifically down regulating their expression . Regulation CCL2 STAT4 21646799 2442021 *plays* an essential role in IFN-ß induced [MCP-1] mRNA expression in mast cells . Regulation CCL2 TGM2 22921425 2678270 In turn , activity *affects* the expression of [MCP-1] in vitro and monocyte recruitment in vivo . Regulation CCL2 TLR7 15588425 1345934 MEFs were highly responsive to TLR-ligand activation and secreted high levels of both IL-6 and [MCP-1] in *response* to ligands . Regulation CCL2 TLR7 17641061 1771351 IFN-gamma mediated survival enables human neutrophils to produce [MCP-1/CCL2] in *response* to activation by ligands . Regulation CCL2 TNF 10079141 597391 In the present study , we investigated the role of IL-8 and [MCP-1] and *regulation* of these chemokines by and IL-1 in LPS induced uveitis in rabbits . Regulation CCL2 TNF 10331497 614619 MCP-1 is selectively expressed in the late phase by cytokine stimulated human neutrophils : *plays* a role in maximal [MCP-1] mRNA expression . Regulation CCL2 TNF 10496934 647238 Divergent *roles* of and platelet activating factor in endotoxin induced release of [monocyte chemoattractant protein 1] and macrophage inflammatory protein 1beta in chimpanzees . Regulation CCL2 TNF 10602073 655220 Endothelial cells ( EC ) from human aortas , microvessels , and pulmonary arteries were examined for their expression and activity of [monocyte chemotactic protein-1 (MCP-1)] , tissue factor , and thrombomodulin in *response* to on the hydrophilic plasma polymers gamma-butyrolactone ( GBL ) and N-vinyl-2-pyrrolidone ( NVP ) , along with a fibronectin (FN) control . Regulation CCL2 TNF 10880246 709110 On the other hand , [JE/MCP-1] mRNA expression was detected only in non-parenchymal cells in *response* to and IL-1beta , but not in response to IFN-gamma . Regulation CCL2 TNF 11006087 735194 These results indicate that *dependent* expression of [MCP-1] in HASMC is tightly regulated by NF-kappaB and that intracellular copper level is crucial for the TNF-alpha dependent activation of NF-kappaB in HASMC . Regulation CCL2 TNF 11164890 763143 mediated *regulation* of [MCP-1] occurs through a distal regulatory region located 2.5 kb upstream of the transcriptional start site . Regulation CCL2 TNF 11244034 792275 Clinical investigations in which the activity of TNF alpha in RA patients was blocked with intravenously administered infliximab , a chimeric anti-TNF alpha monoclonal antibody ( mAB ) , has provided evidence that *regulates* IL-6 , IL-8 , [MCP-1] , and VEGF production , recruitment of immune and inflammatory cells into joints , angiogenesis , and reduction of blood levels of matrix metalloproteinases-1 and -3 . Regulation CCL2 TNF 11673556 872884 On the other hand , [CCL2] , CCL5 , and CXCL12 were expressed on RA FLS , and their production was *regulated* by , IL-1beta , and TGF-beta1 . Regulation CCL2 TNF 11748220 905526 Antisense oligonucleotide suppression of zfm1 protein synthesis mimicked the stimulatory *effects* of IL-1 beta and on SMC proliferation and expression of the chemokine [MCP-1] and the vascular cell adhesion molecule-1 . Regulation CCL2 TNF 11891780 920512 Of note , we present evidence that may be involved in regulating RANTES and MIP-1alpha , and that IL-4 may be *involved* in regulating [MCP-1] . Regulation CCL2 TNF 11922866 984264 In this study , we examined the NF-kappaB mediated *effects* of RSV and the proinflammatory cytokine on the induction of IL-8 , [MCP-1] and RANTES chemokine gene expression in A549 epithelial cells . Regulation CCL2 TNF 12682245 1077655 To investigate how these regions coordinate activation of [MCP-1] in *response* to , experiments were performed to examine the role of coactivators , changes in local chromatin structure , and the acetylation of histones at the MCP-1 regulatory regions . Regulation CCL2 TNF 12840897 581659 *Effect* of IL-1 beta and on the expression of [monocyte chemotactic protein-1] in endometriotic cells . Regulation CCL2 TNF 15274652 1276721 Our data indicated that M-CSF and [MCP-1] were *regulated* by IL-1alpha and . Regulation CCL2 TNF 16081883 1466276 However , TNF-R2 was dispensable for induction of alveolar [MCP-1] expression in *response* to transmembrane expressed by antigen-specific CD8+ T cells , and the effects of the two receptors seem to be additive . Regulation CCL2 TNF 16190362 1462604 In the present study , we examined the *effects* of hypoxia and on PAI-1 , [MCP-1] and VEGF expression in cultured human proximal renal tubular cells ( HPTECs ) . Regulation CCL2 TNF 16319097 1546926 The effects of VIP on basal or or lipopolysaccharide (LPS) induced TLR2 , TLR4 and MyD88 expression and its *effects* on TLR4 mediated [CCL2] and CXCL8 chemokine production were studied by reverse transcription-polymerase chain reaction , western blotting and enzyme linked immunosorbent assay . Regulation CCL2 TNF 16358608 1492982 In this study , the *effects* of on the expression of [C-C chemokine ligand 2 (CCL2)] in fibroblasts derived from nasal polyps ( NPFs ) were investigated . Regulation CCL2 TNF 16387335 1567072 LTA produced a dose related increase in early pulmonary inflammation , which was characterized by ( 1 ) influx of polymorphonuclear neutrophils ( PMNs ) and ( 2 ) induction of interleukin (IL)-6 , , macrophage inflammatory protein (MIP)-1alpha/CCL3 , but no *effect* on monocyte chemoattractant protein [(MCP)-1/CCL2] at 24 h after instillation . Regulation CCL2 TNF 16847329 1588183 The [monocyte chemoattractant protein 1] gene ( MCP-1 ) is *regulated* by through an NF-kappaB dependent distal enhancer and an Sp1 dependent promoter-proximal regulatory region . Regulation CCL2 TNF 17424890 1723872 In this study , the *effects* of on [CCL2] expression in NPFs and the signaling pathway involved were investigated . Regulation CCL2 TNF 18799549 1981143 We found that , in murine podocytes , expression of [monocyte chemoattractant protein 1] ( MCP-1 ) in *response* to was suppressed by indomethacin but not by ibuprofen . Regulation CCL2 TNF 19107603 2047672 As expected , JNKI-1 blocked the stimulatory *effect* of on the [MCP-1] promoter activity . Regulation CCL2 TNF 19122171 2037061 IGF1R downregulation uncovered an insulin induced reduction in activation of NF-kappaB and inhibition of [MCP-1] upregulation in *response* to . Regulation CCL2 TNF 19124762 2019594 Priming of the cells with ER stress inducers ( tunicamycin , thapsigargin , A23187 , and AB5 subtilase cytotoxin ) caused blunted induction of [MCP-1] in *response* to , IL-1beta , macrophage derived factors , or bystander macrophages . Regulation CCL2 TNF 19426980 2157197 [MCP-1] expression was *regulated* by IL-1beta and and cytokine induced PREB expression . Regulation CCL2 TNF 19439823 2090484 Furthermore , these data suggested that [MCP-1] was *regulated* by and IL-1beta , and activated by both cytokines and biomaterials . Regulation CCL2 TNF 20015519 2264534 Leptin and secretion showed a similar tendency without significant intergroup differences , and [monocyte chemoattractant protein-1] release was not *affected* by Ca deficiency . Regulation CCL2 TNF 21419119 2432118 Extracellular HIV-1 Tat upregulates *dependent* [MCP-1/CCL2] production via activation of ERK1/2 pathway in rat hippocampal slice cultures : inhibition by resveratrol , a polyphenolic phytostilbene . Regulation CCL2 TNF 22378921 2587254 We have tested the *effect* of interferon ? ( IFN? ( IFNG ) ) and on [CCL2] , and for comparison on the prototype a chemokine (C-X-C motif) ligand 10 ( CXCL10 ) , and the possible modulatory role of PPARa activation on secretion of these chemokines in normal and GO fibroblasts or preadipocytes in primary cell cultures . Regulation CCL2 TNF 22575505 2603609 Here , we demonstrate that clusterin upregulates the expressions of chemotactic cytokines , that is , [monocyte chemotactic protein-1 (MCP-1)] , macrophage inflammatory protein-1ß ( MIP-1ß ) , *regulated* upon activation , normal T cell expressed and secreted ( RANTES ) , and in Raw264.7 macrophages . Regulation CCL2 TNF 7891669 289766 This result suggested that the *regulation* of [MCP-1] gene involves other parts of the gene besides the proximal 5 ' flanking region . Regulation CCL2 TNF 8382248 212097 *Regulation* of [monocyte chemoattractant protein-1] and macrophage colony stimulating factor-1 by IFN-gamma , , IgG aggregates , and cAMP in mouse mesangial cells . Regulation CCL2 TNF 8424834 210929 These studies demonstrate that the [MCP-1] gene is *regulated* by and IFN gamma in type B synoviocytes and indicate that these cells may play an important role in the recruitment of inflammatory cells to the rheumatoid synovial environment , via the production of novel chemotactic cytokines such as MCP-1 . Regulation CCL2 TNF 8507217 221502 Fibroblast-like synoviocytes were found to express MCAF mRNA and to secrete [MCAF] in *response* to interleukin-1 (IL-1) and in vitro . Regulation CCL2 TNF 8793801 381094 *Role* of on mesangial cell [MCP-1] expression and monocyte migration : mechanisms mediated by signal transduction . Regulation CCL2 TNF 8945953 400364 This attenuation is comparable to the *effect* on the chemokine [MCP-1] . Regulation CCL2 TNF 9375973 465375 IL-13 , but not IL-10 , significantly enhanced IL-8 and [MCP-1] release in *response* to IL-1alpha or . Regulation CCL2 TNF 9376623 465520 MKN28 cells were found to secrete [MCP-1] in *response* to IL-1 beta or in a dose- and time dependent manner . Regulation CCL2 TNF 9405974 470410 Cilostazol , a cAMP phosphodiesterase inhibitor , attenuates the production of [monocyte chemoattractant protein-1] in *response* to in vascular endothelial cells . Regulation CCL2 TNF 9714185 527662 The production of [monocyte chemoattractant protein-1] ( MCP-1 ) and its *regulation* by , IL-1 , and IL-8 were investigated in two rabbit models of arthritis induced by intra-articular injection of lipopolysaccharide (LPS) or monosodium urate ( MSU ) crystals . Regulation CCL2 TNF 9714185 527669 Thus , the production of [MCP-1] in LPS induced arthritis was mostly *regulated* by and IL-1 , whereas half the extent of MCP-1 production in MSU crystal induced arthritis was independent of TNFalpha or IL-1 . Regulation CCL2 TNF 9916692 587482 transcriptionally *regulates* murine [monocyte chemoattractant protein-1] ( MCP-1 ) expression . Regulation CCL2 TNF 9916692 587485 Trans-activation studies conducted by cotransfection of p50 and/or p65 expression vectors with MCP-1 constructions showed that *regulates* [MCP-1] through NF-kappa B . Regulation CCL20 EPHB2 16232215 1470396 On the other hand , we found that not only NF-kappaB , p38 MAPK and but also c-Jun NH2-terminal kinase (JNK) are *involved* in [CCL20] production induced by E. coli LPS . Regulation CCL20 IL1B 11472439 841475 Cultured synovial fibroblasts derived from either RA or OA patients were capable of producing [MIP-3 alpha] in *response* to and TNFalpha in vitro . Regulation CCL20 TNF 11472439 841474 Cultured synovial fibroblasts derived from either RA or OA patients were capable of producing [MIP-3 alpha] in *response* to IL-1 beta and in vitro . Regulation CCL20 TNF 15474097 1318884 The *effects* of interleukin (IL)-1alpha , IL-1 receptor antagonist (RA) , and on the secretion of [MIP-3alpha] by primary cultured granulosa-lutein cells and an immortalized granulosa cell line ( GC1a ) were investigated . Regulation CCL20 TNF 15474097 1318887 Our data suggest that [MIP-3alpha] was present in follicular fluid and correlated with oocyte maturation , and was *regulated* by IL-1alpha and . Regulation CCL20 TNF 23800251 2808005 Finally , [CCL20] and CXCL8 responded synergistically in *response* to EGF and in OVCAR-3 and SKOV-3 cells . Regulation CCL21 PECAM1 24009720 2836872 PI3K p110d is expressed by gp38 ( - ) ( + ) and gp38 ( + ) CD31 ( + ) spleen stromal cells and *regulates* their CCL19 , [CCL21] , and LTßR mRNA levels . Regulation CCL21 TNF 17236235 1696422 *dependent* overexpression of [CCL21] is an underlying cause of progressive lymphoaccumulation in generalized lymphoproliferative disorder . Regulation CCL23 TNF 23331383 2803468 *Effects* of interleukin-1ß and on [macrophage inflammatory protein-3a] production in synovial fibroblast-like cells from human temporomandibular joints . Regulation CCL26 TNF 11544308 855309 Although both eotaxin-1 and -3 are regulated by this transcription factor , the *response* of the [eotaxin-3] gene to stimulation appears to be different . Regulation CCL26 TNF 16755001 1571588 Differential *regulation* of eotaxin-1/CCL11 and [eotaxin-3/CCL26] production by the and IL-4 stimulated human lung fibroblast . Regulation CCL26 TNF 16755001 1571592 We observed that a human lung fibroblast , HFL-1 produces [eotaxin-1 and -3] in *response* to plus IL-4 stimulation , accompanied with NF-kappaB and STAT6 activation . Regulation CCL26 TNF 17073866 1637968 Dermal fibroblasts produced eotaxin and [eotaxin-3] in *response* to stimulation by interleukin (IL)-4 and/or . Regulation CCL28 IL1B 16785557 1577137 [CCL28] was secreted by primary human cholangiocytes in vitro in *response* to LPS , , or bile acids . Regulation CCL3 IL1B 12603824 1062520 These data suggest that NF-kappaB is at least partially involved in the mediated *action* on [MIP-1alpha] and -1beta in NT2-N cells . Regulation CCL3 IL1B 7629889 316753 , tumor necrosis factor alpha , and MIP-1 alpha had no *effect* on [MIP-1 alpha] mRNA expression . Regulation CCL3 IL1B 9570566 501610 In *response* to LPS , TNF-alpha , or , both [MIP-1 alpha] and MIP-1 beta were induced at the mRNA and protein levels in a dose- and time dependent manner . Regulation CCL3 TNF 10877490 708904 Results of these studies show that the anti-viral resistance induced by activation of CD4+ T cells with anti-CD3 + anti-CD28 is primarily conferred by the synthesis of tumor necrosis factor-alpha (TNF-alpha) , and highlight a unique regulatory *role* for in regulating synthesis of [MIP-1alpha] , MIP-1beta , and regulated-on-activation normal T-expressed and secreted cells , which contributes to this state of antiviral resistance to R5-tropic strains of HIV/SIV . Regulation CCL3 TNF 11425892 831381 [MIP-1alpha] , MCP-1 , GM-CSF , and *control* the immune cell response that mediates rapid phagocytosis of myelin from the adult mouse spinal cord . Regulation CCL3 TNF 11891780 920514 Of note , we present evidence that may be *involved* in regulating RANTES and [MIP-1alpha] , and that IL-4 may be involved in regulating MCP-1 . Regulation CCL3 TNF 16940249 1615476 However , cases with pulmonary edema had significantly lower cellular gamma-interferon ( p = 0.04 ) , lower cellular IL-1beta ( p = 0.04 ) , lower cellular IL-6 ( p = 0.04 ) , lower cellular *response* ( p = 0.04 ) , and lower cellular [macrophage inflammatory protein-1alpha] ( p = 0.04 ) response compared with other cases . Regulation CCL3 TNF 9570566 501609 In *response* to LPS , , or IL-1 beta , both [MIP-1 alpha] and MIP-1 beta were induced at the mRNA and protein levels in a dose- and time dependent manner . Regulation CCL4 IL1B 12527330 1048284 Rhein partially reversed the *effect* of on TIMP-1 and NO production , had no effect on AGG , IL-6 and [MIP-1beta] production , but up-regulated the IL-1beta stimulated PGE ( 2 ) production . Regulation CCL4 IL1B 12603824 1062523 These data suggest that NF-kappaB is at least partially involved in the mediated *action* on [MIP-1alpha and -1beta] in NT2-N cells . Regulation CCL4 IL1B 9570566 501612 In *response* to LPS , TNF-alpha , or , both MIP-1 alpha and [MIP-1 beta] were induced at the mRNA and protein levels in a dose- and time dependent manner . Regulation CCL4 TNF 10496934 647239 Divergent *roles* of and platelet activating factor in endotoxin induced release of monocyte chemoattractant protein 1 and [macrophage inflammatory protein 1beta] in chimpanzees . Regulation CCL4 TNF 9570566 501611 In *response* to LPS , , or IL-1 beta , both MIP-1 alpha and [MIP-1 beta] were induced at the mRNA and protein levels in a dose- and time dependent manner . Regulation CCL5 IL1B 11673556 872888 On the other hand , CCL2 , [CCL5] , and CXCL12 were expressed on RA FLS , and their production was *regulated* by TNF-alpha , , and TGF-beta1 . Regulation CCL5 TNF 11673556 872887 On the other hand , CCL2 , [CCL5] , and CXCL12 were expressed on RA FLS , and their production was *regulated* by , IL-1beta , and TGF-beta1 . Regulation CCL5 TNF 19353522 2064851 C/EBPbeta knockdown also inhibited the synergistic expression of CXCL1 , inducible nitric oxide synthase , and [CCL5] in *response* to concomitant IFNgamma and . Regulation CCL7 EPHB2 12854631 1110258 We conclude that p38 MAPK , JNK kinase , and NF-kappaB are *involved* in the IL-1beta induced eotaxin , MCP-1 , and [MCP-3] expression and release in HASMC . Regulation CCNB1 CCND1 9137822 427925 To our knowledge this is the first report showing positive *effect* of cyclin A , cyclin E and on [cyclin B1] activation and blocking of this activation by a Cdk2 dominant negative mutant . Regulation CCNC TF 2440461 74276 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation CCNC TNF 14550746 1152757 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation CCNC TNF 17307735 1719119 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation CCNC TNF 17988550 1821537 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation CCND1 ABCC6 17510080 1778276 is *involved* in transcriptional regulation of the [cyclin D1] gene in human cancer cells . Regulation CCND1 ABCC6 17510080 1778279 In this study , we identified a novel *role* for in the regulation of [cyclin D1] expression in the absence of AR stimulation in human cancer cells . Regulation CCND1 AKT1 12124352 965752 Herceptin induced inhibition of phosphatidylinositol-3 kinase and Is required for antibody mediated *effects* on p27 , [cyclin D1] , and antitumor action . Regulation CCND1 AKT1 15634685 1380928 [Cyclin D1] and c-myc internal ribosome entry site ( IRES ) -dependent translation is *regulated* by activity and enhanced by rapamycin through a p38 MAPK- and ERK dependent pathway . Regulation CCND1 AKT1 20724534 2306867 These findings demonstrate for the first time that *dependent* [cyclin D1] activation plays an essential role in HDL induced EPC proliferation , migration and angiogenesis . Regulation CCND1 AKT1 21135252 2377993 AP-1 regulates [cyclin D1] and c-MYC transcription in an *dependent* manner in response to mTOR inhibition : role of AIP4/Itch mediated JUNB degradation . Regulation CCND1 AKT1 21135252 2378007 Our previous data suggested that [cyclin D1] and c-MYC expression might additionally be coordinately regulated in an *dependent* manner at the level of transcription . Regulation CCND1 AKT1 21777670 2484521 The major effect of Akt3 on the proliferation of DTC was associated with an Akt3 mediated regulation of both , cyclin D1 and cyclin D3 , whereas *regulated* the expression of [cyclin D1] only . Regulation CCND1 AKT2 12124352 965753 Herceptin induced inhibition of phosphatidylinositol-3 kinase and Is required for antibody mediated *effects* on p27 , [cyclin D1] , and antitumor action . Regulation CCND1 AKT2 15634685 1380929 [Cyclin D1] and c-myc internal ribosome entry site ( IRES ) -dependent translation is *regulated* by activity and enhanced by rapamycin through a p38 MAPK- and ERK dependent pathway . Regulation CCND1 AKT2 20724534 2306868 These findings demonstrate for the first time that *dependent* [cyclin D1] activation plays an essential role in HDL induced EPC proliferation , migration and angiogenesis . Regulation CCND1 AKT2 21135252 2377994 AP-1 regulates [cyclin D1] and c-MYC transcription in an *dependent* manner in response to mTOR inhibition : role of AIP4/Itch mediated JUNB degradation . Regulation CCND1 AKT2 21135252 2378008 Our previous data suggested that [cyclin D1] and c-MYC expression might additionally be coordinately regulated in an *dependent* manner at the level of transcription . Regulation CCND1 AKT3 12124352 965754 Herceptin induced inhibition of phosphatidylinositol-3 kinase and Is required for antibody mediated *effects* on p27 , [cyclin D1] , and antitumor action . Regulation CCND1 AKT3 15634685 1380930 [Cyclin D1] and c-myc internal ribosome entry site ( IRES ) -dependent translation is *regulated* by activity and enhanced by rapamycin through a p38 MAPK- and ERK dependent pathway . Regulation CCND1 AKT3 20724534 2306869 These findings demonstrate for the first time that *dependent* [cyclin D1] activation plays an essential role in HDL induced EPC proliferation , migration and angiogenesis . Regulation CCND1 AKT3 21135252 2377995 AP-1 regulates [cyclin D1] and c-MYC transcription in an *dependent* manner in response to mTOR inhibition : role of AIP4/Itch mediated JUNB degradation . Regulation CCND1 AKT3 21135252 2378009 Our previous data suggested that [cyclin D1] and c-MYC expression might additionally be coordinately regulated in an *dependent* manner at the level of transcription . Regulation CCND1 AKT3 21777670 2484522 The major effect of Akt3 on the proliferation of DTC was associated with an mediated *regulation* of both , [cyclin D1] and cyclin D3 , whereas Akt1 regulated the expression of cyclin D1 only . Regulation CCND1 ANXA6 12165850 972986 This leads ( a ) to an increase in the S6 kinase dependent *regulation* of the steady-state level of [cyclin D1] , and ( b ) to a concomitant decrease in the GSK3beta dependent rate of cyclin D1 degradation . Regulation CCND1 ANXA6 19801633 2164106 In addition , we clarified that ( s6k ) is also *involved* in B [ a ] PDE induced [cyclin D1] expression because rampamycin pretreatment dramatically reduced cyclin D1 induction by B [ a ] PDE . Regulation CCND1 APC 19415698 2135720 While *dependent* expression of [CYCLIN D1] was observed in vivo and in vitro , expression of PPAR beta/delta was not different in colon or intestinal polyps from wild-type or Apc ( min ) heterozygous mice or in human colon cancer cell lines with mutations in APC and/or beta-CATENIN . Regulation CCND1 ASIP 17617380 1769541 Taken together , these results suggested that arsenic trioxide inhibited gallbladder carcinoma cell proliferation via down-regulation of [Cyclin D1] transcription in *dependent* manner , which provided a new mechanism of arsenic trioxide involved cell proliferation and may have important therapeutic implications in gallbladder carcinoma patients . Regulation CCND1 ATF2 10500157 648055 To interpret these results , we propose a mechanism in which heterodimers bind to the CRE-D1 element and *mediate* the activation of [cyclin D1] promoter by the ER . Regulation CCND1 ATF2 15691880 1371470 Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on [cyclin D1] *involving* the transcription factor in MCF-7 breast cancer cells . Regulation CCND1 ATF3 11375399 834923 These results indicate that ATF3 expression stimulates hepatocellular proliferation , suggesting that this effect is mediated , at least in part , by the *dependent* activation of [cyclin D1] transcription . Regulation CCND1 ATM 23776433 2802210 Correspondingly , NF-?B inhibitor blocked the *effect* of on up-regulation of [cyclin D1] and c-Myc . Regulation CCND1 ATR 18606783 1947251 Phosphorylation of [cyclin D1] *regulated* by ATM or controls cell cycle progression . Regulation CCND1 ATR 18606783 1947254 Small interfering RNA against ATR inhibited UV-induced Thr286 phosphorylation , together with that seen in normally cycling cells , indicating that *regulates* [cyclin D1] phosphorylation in normal as well as stressed cells . Regulation CCND1 BCL10 21911473 2496827 Collectively , these data reveal a requisite *role* for the SCF ( Fbx4 ) E3 in regulating [cyclin D1] accumulation , consistent with tumor suppressive function in vivo . Regulation CCND1 BRCA1 16860316 1607265 *regulates* [cyclin D1] expression in breast cancer cells . Regulation CCND1 BTC 19105244 2004129 Rapamycin also inhibited betacellulin- and IGF-I induced entry of cells into S phase and 5'-Bromo-2'-deoxyuridine incorporation as well as the *effect* of and IGF-I on [cyclin D1] expression and nuclear exclusion of p21 ( Cip1 ) and p(27Kip1) . Regulation CCND1 BTG2 19263516 2045435 Using DNA microarrays , Real-Time RT-PCR and western blot , we demonstrated that nuclear DGK-zeta downregulated the expression of cyclin D1 and increased the expression of , a transcriptional *regulator* of [cyclin D1] with a strong anti-proliferative function . Regulation CCND1 BTG2 23420441 2787250 Additionally , the *effects* of expression on [cyclin D1] , caspase 3 , and matrix metalloproteinases 1/2 (MMP-1/-2) expression were analyzed . Regulation CCND1 CA2 9353308 461464 Addition of purified calpain to PC-3-M lysates resulted in *dependent* [cyclin D1] degradation . Regulation CCND1 CAPN1 9353308 461451 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Regulation CCND1 CAPN10 9353308 461452 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Regulation CCND1 CAPN11 9353308 461453 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Regulation CCND1 CAPN12 9353308 461450 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Regulation CCND1 CAPN13 9353308 461461 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Regulation CCND1 CAPN14 9353308 461462 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Regulation CCND1 CAPN15 9353308 461449 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Regulation CCND1 CAPN2 9353308 461454 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Regulation CCND1 CAPN3 9353308 461455 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Regulation CCND1 CAPN5 9353308 461456 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Regulation CCND1 CAPN6 9353308 461457 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Regulation CCND1 CAPN7 9353308 461458 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Regulation CCND1 CAPN8 9353308 461459 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Regulation CCND1 CAPN9 9353308 461460 Here we present evidence that [cyclin D1] levels are *regulated* at the posttranscriptional level by the Ca2+ activated protease . Regulation CCND1 CARD10 22884800 2666197 NF-?B inhibitor BAY 11-7082 reversed the *role* of on [cyclin D1] upregulation . Regulation CCND1 CASP1 14647418 1210449 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Regulation CCND1 CASP1 15585645 1345666 [Cyclin D1] degradation *involved* , a regulatory component of the Skp1/Cullin/F-box complex ; Regulation CCND1 CASP10 14647418 1210450 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Regulation CCND1 CASP12 14647418 1210460 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Regulation CCND1 CASP14 14647418 1210451 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Regulation CCND1 CASP16 14647418 1210461 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Regulation CCND1 CASP2 14647418 1210452 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Regulation CCND1 CASP3 14647418 1210453 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Regulation CCND1 CASP4 14647418 1210454 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Regulation CCND1 CASP5 14647418 1210455 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Regulation CCND1 CASP6 14647418 1210456 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Regulation CCND1 CASP7 14647418 1210457 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Regulation CCND1 CASP8 14647418 1210458 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Regulation CCND1 CASP9 14647418 1210459 Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites , as well as the *dependent* downregulation of [cyclin D1] . Regulation CCND1 CASR 17482347 1778125 The study investigated [cyclin D1] *regulation* by growth factors and in human tumoral parathyroid cells . Regulation CCND1 CBX8 19263516 2045436 Using DNA microarrays , Real-Time RT-PCR and western blot , we demonstrated that nuclear DGK-zeta downregulated the expression of cyclin D1 and increased the expression of , a transcriptional *regulator* of [cyclin D1] with a strong anti-proliferative function . Regulation CCND1 CD44 17296798 1698896 Analysis of arteries from wild-type and CD44-null mice showed that the *effects* of on [cyclin D1] and Skp2 gene expression are detected in vivo and are associated with altered SMC proliferation after vascular injury . Regulation CCND1 CDC42 12919678 1130875 Instead , specific mutation of its nuclear localization and export sequences showed that LIM kinase acts in the nucleus to suppress *dependent* [cyclin D1] expression . Regulation CCND1 CDK2 15951563 1440631 In addition to its binding dependent functions , [cyclin D1] *regulates* cellular differentiation in part by modifying several transcription factors and nuclear receptors . Regulation CCND1 CDK2 15951563 1440632 [Cyclin D1] repression of p300 was *independent* of the and retinoblastoma protein binding domains of cyclin D1 . Regulation CCND1 CDK2 9828096 551015 Cellular levels of PCNA , [cyclin D1] , and cyclin E were not *affected* by the inhibitors . Regulation CCND1 CDK4 16413469 1514317 We report that the ability of cyclin D1 to activate cyclin dependent kinase *underlies* the critical role for [cyclin D1] in breast cancer formation . Regulation CCND1 CDK4 16699726 1584325 Cyclin D1 and are rate limiting regulators of the G1 -- > S transition and expression of [cyclin D1] is predominantly *regulated* by ERK1/2 pathway in HELF cells . Regulation CCND1 CDK4 23892435 2821763 Restoration of CASZ1 decreases Cdk2 dependent cyclins A and E protein levels and *dependent* [Cyclin D1] protein levels . Regulation CCND1 CDK4 9178893 434271 In contrast , and Cdk6 were predominantly *responsible* for [cyclin D1-associated] kinase activity as previously reported . Regulation CCND1 CDK6 23892435 2821764 Restoration of CASZ1 decreases Cdk2 dependent cyclins A and E protein levels and *dependent* [Cyclin D1] protein levels . Regulation CCND1 CDK6 9178893 434272 In contrast , Cdk4 and were predominantly *responsible* for [cyclin D1-associated] kinase activity as previously reported . Regulation CCND1 CDKN1A 17443686 1760946 We found that the decrease in [cyclin D1] levels induced by NO was GSH-sensitive implying that the redox regulation of NO-mediated cytostasis was a multifaceted process and that both and p53 independent cyclin D1 pathways were *involved* . Regulation CCND1 CDKN1A 19306413 2056199 High concentrations of soil extracts decreased [cyclin D1] and increased *response* , indicating cell cycle arrest . Regulation CCND1 CDKN2A 16100943 1444125 It is widely known that can arrest cells in the G1 phase , but how the expression of exogenous P16INK4 gene can *affect* the activity of [Cdk4-Cyclin D1] remains unclear . Regulation CCND1 CDKN2A 22860097 2640983 post-transcriptional *regulation* of nuclear [cyclin D1] in MCF-7 breast cancer cells : discrimination between a good and bad prognosis ? Regulation CCND1 CDX2 19106744 2018788 This study is intended to investigate the *effect* of expression on cell proliferation and [cyclin D1] expression in pancreatic cancer cells . Regulation CCND1 CDX2 19106744 2018789 Luciferase assay was performed to examine the *effects* of on [cyclin D1] transcriptional activity . Regulation CCND1 CEBPB 18413814 1894234 Furthermore , in flat ACF , EGFR blockade decreased the up-regulation of c-Jun , FosB , phosphorylated active signal transducers and activators of transcription 3 , and , potential *regulators* of [cyclin D1] and Cox-2 . Regulation CCND1 CEND1 24312406 2877947 Functional Interactions between , Ran binding protein M and Dyrk1B kinase *affect* [cyclin D1] levels and cell cycle progression/exit in mouse neuroblastoma cells . Regulation CCND1 CFL1 12919678 1130869 Surprisingly , inhibition of Rac dependent [cyclin D1] expression by LIM kinase is *independent* of both phosphorylation and actin polymerization . Regulation CCND1 CFL2 12919678 1130870 Surprisingly , inhibition of Rac dependent [cyclin D1] expression by LIM kinase is *independent* of both phosphorylation and actin polymerization . Regulation CCND1 CHUK 18792914 2008961 Taken together , we demonstrate that soluble , but not insoluble nickel compound , is able to cause [cyclin D1] degradation and a cell growth arrest in an *dependent* manner . Regulation CCND1 CHUK 20080131 2218714 Notably , dependent [Cyclin D1] *regulation* is unrelated to IKKbeta/NF-kappaB activity . Regulation CCND1 CHUK 20080131 2218717 We further show that *dependent* downregulation of [Cyclin D1] expression in the UVB response results from the reduction of ERK1/2 dependent Cyclin D1 transcription coupled with an increase of p38 kinase dependent Cyclin D1 proteolysis . Regulation CCND1 CNTN2 11992406 938698 Inhibitors of NF-kappaB ( dominant negative IkappaBs mutants ) suppressed *dependent* activation of [cyclin D1] and D2 promoters , indicating that Tax induced activation was mediated by NF-kappaB . Regulation CCND1 CREB1 16522741 1531504 Lastly , a transfection assay employing constitutively active or dominant negative CREB expression plasmids clearly demonstrated that was largely *involved* in both basal and EX-induced [cyclin D1] promoter activities . Regulation CCND1 CREB1 18957421 1995061 *Regulation* of [cyclin D1] and Wnt10b gene expression by during early adipogenesis involves differential promoter methylation . Regulation CCND1 CREB1 24979279 2947674 [Cyclin D1] is highly *dependent* , whereas cyclin B1 and PCNA are co-regulated by both CREB dependent and -independent mechanisms . Regulation CCND1 CREB3 16522741 1531505 Lastly , a transfection assay employing constitutively active or dominant negative CREB expression plasmids clearly demonstrated that was largely *involved* in both basal and EX-induced [cyclin D1] promoter activities . Regulation CCND1 CREB3 18957421 1995062 *Regulation* of [cyclin D1] and Wnt10b gene expression by during early adipogenesis involves differential promoter methylation . Regulation CCND1 CREB3 24979279 2947675 [Cyclin D1] is highly *dependent* , whereas cyclin B1 and PCNA are co-regulated by both CREB dependent and -independent mechanisms . Regulation CCND1 CREB5 16522741 1531503 Lastly , a transfection assay employing constitutively active or dominant negative CREB expression plasmids clearly demonstrated that was largely *involved* in both basal and EX-induced [cyclin D1] promoter activities . Regulation CCND1 CREB5 18957421 1995060 *Regulation* of [cyclin D1] and Wnt10b gene expression by during early adipogenesis involves differential promoter methylation . Regulation CCND1 CREB5 24979279 2947673 [Cyclin D1] is highly *dependent* , whereas cyclin B1 and PCNA are co-regulated by both CREB dependent and -independent mechanisms . Regulation CCND1 CRK 10952989 744320 Osmotic stress regulates the stability of [cyclin D1] in a *dependent* manner . Regulation CCND1 CRK 16125882 1499116 These results demonstrate that ERKs and JNKs , but not is *responsible* for induction of [cyclin D1] and CDK4 in S-HELF , suggesting that overexpression of cyclin D1 and CDK4 caused by silica is mediated by ERK , JNK/AP 1signaling pathway . Regulation CCND1 CSE 20819634 2315110 To elucidate the molecular mechanisms leading to these changes , we studied in vitro the *effect* of on the proliferation of ASMCs and the expression of [cyclin D1] , an important regulatory protein implicated in cell cycle . Regulation CCND1 CSF1 9372970 464725 When we transfected cells expressing CSF-1R ( Y809F ) with mPIP5K-Ibeta ( delta1-238 ) , *dependent* induction of c-MYC and [cyclin D1] was restored and ligand dependent cell proliferation was sustained . Regulation CCND1 CTDP1 22264791 2545033 CREPT *regulates* [cyclin D1] expression by binding to its promoter , enhancing its transcription both in vivo and in vitro , and interacting with . Regulation CCND1 CTNNB1 10201372 605417 *regulates* expression of [cyclin D1] in colon carcinoma cells . Regulation CCND1 CTNNB1 10679386 668919 For instance the discovery that [cyclin D1] is *regulated* by allows us to tie the APC pathway to the RB pathway and cell cycle control . Regulation CCND1 CTNNB1 11266469 796925 PS1 deficiency results in accumulation of cytosolic beta-catenin , leading to a *dependent* increase in [cyclin D1] transcription and accelerated entry into the S phase of the cell cycle . Regulation CCND1 CTNNB1 11592102 869637 The immunohistochemical expression of beta-catenin , cyclin D1 , Ki-67 and PCNA was Examined in 38 cases of sporadic extra-abdominal or abdominal-wall desmoid tumours without familial adenomatous polyposis (FAP) , to evaluate the hypothesis that the accumulated within the nuclei could *affect* the regulation of the [cyclin D1] gene . Regulation CCND1 CTNNB1 12951064 1137338 In the presence of T3 , *dependent* transactivation of [cyclin D1] promoter was suppressed by co-transfection of TRbeta1 . Regulation CCND1 CTNNB1 14764597 1235125 Since beta-catenin plays a pivotal role in regulating cyclin D1 transcription , we studied whether PPARgamma2 mediated inhibition of [cyclin D1] transcription *involved* . Regulation CCND1 CTNNB1 15126340 1244830 Because [cyclin D1] is mainly *regulated* by factor (TCF) , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Regulation CCND1 CTNNB1 15377999 1323926 Furthermore , we show that [Cyclin D1] , an important biological Wnt target gene , is regulated by Rac1 in a *dependent* manner . Regulation CCND1 CTNNB1 15573917 1344514 In cell lines , it has been reported previously that and K-ras *play* the same roles in activation of [cyclin D1] transcription . Regulation CCND1 CTNNB1 15946752 1452171 signaling and *regulation* of [cyclin D1] promoter in NRK-49F cells transformed by down-regulation of the tumor suppressor lysyl oxidase . Regulation CCND1 CTNNB1 17079480 1642923 Nuclear localized aptamer inhibited *dependent* transcription of [cyclin D1] and c-myc in colon cancer cells ; Regulation CCND1 CTNNB1 17275129 1718293 An associated inhibition of *dependent* Tcf reporter activity , decreased levels of downstream target gene products glutamine synthetase and [cyclin-D1] , and decreased proliferation and survival of hepatoma cells was evident . Regulation CCND1 CTNNB1 17376431 1748341 Finally , we found that the accumulation of was *involved* in the repair of scratch wounds by promoting the expression of [cyclin D1] that linked to cell proliferation . Regulation CCND1 CTNNB1 19415698 2135719 While *dependent* expression of [CYCLIN D1] was observed in vivo and in vitro , expression of PPAR beta/delta was not different in colon or intestinal polyps from wild-type or Apc ( min ) heterozygous mice or in human colon cancer cell lines with mutations in APC and/or beta-CATENIN . Regulation CCND1 CTNND1 16534869 1536562 Furthermore , overexpression of down *regulated* the expression of apoptotic protein survivin and cell cycle regulator [cyclin D1] . Regulation CCND1 CTNND1 22276175 2545288 Interestingly , overexpression of p120ctn-1A increased ß-catenin and cyclin D1 expression , while co-transfection with siRNA targeting ß-catenin abolishes the *effect* of on up-regulation of [cyclin D1] , suggesting a role of ß-catenin in mediating p120ctn-1A 's regulatory function on cyclin D1 expression . Regulation CCND1 DUSP1 19892016 2184622 and that induces growth arrest of osteoblasts , via inactivating pERK1/2 and down *regulating* [cyclin D1] ; Regulation CCND1 DYRK1B 17046823 1654490 *Involvement* of GSK-3beta and in differentiation inducing factor-3 induced phosphorylation of [cyclin D1] in HeLa cells . Regulation CCND1 E2F1 22613989 2603847 Then we determined the *effects* of KLF15 and its downstream target , cell cycle regulation factor on the proliferation of mesangial cells and the expression of the positive acting cell cycle regulatory proteins , [cyclinD1] and CDK2 , by means of positive and negative interference experiments in cultured rat mesangial cells . Regulation CCND1 E2F1 23543735 2788899 Taken together , our results demonstrate that GCN5 specifically potentiates lung cancer growth by directly promoting the expression of E2F1 , [cyclin D1] , and cyclin E1 in an *dependent* manner . Regulation CCND1 E2F1 9584162 505033 Differential *regulation* of the [cyclin D1] promoter by and E2F-4 suggests that E2Fs may serve distinguishable functions during cell cycle progression . Regulation CCND1 E2F4 9584162 505034 Differential *regulation* of the [cyclin D1] promoter by E2F-1 and suggests that E2Fs may serve distinguishable functions during cell cycle progression . Regulation CCND1 ECM1 22678010 2611466 We wondered whether interaction was *involved* in the regulation of [cyclin D1] expression , and the possible signaling pathways in mitogen stimulating podocytes . Regulation CCND1 ECM2 22678010 2611467 We wondered whether interaction was *involved* in the regulation of [cyclin D1] expression , and the possible signaling pathways in mitogen stimulating podocytes . Regulation CCND1 EGF 10228944 610931 However , had no significant *effect* on the expression of [cyclin D1] or cyclin E . Regulation CCND1 EGF 15511088 1328211 In contrast , expression of Rin1 : delta , a natural splice variant of Rin1 lacking 47 amino acids in the Vps9p domain or Rab5 , increase both activation of Raf-Erk1/2- and [cyclin D1] transcription in *response* to . Regulation CCND1 EGF 24126105 2867926 Depletion of Gab1 , using siRNA , decreased the ERK and Akt activation , [cyclin D1] expression , and DNA synthesis in *response* to both and HGF . Regulation CCND1 EGF 25135222 2957401 Chromatin immunoprecipitation assays revealed that TIP30 negatively regulated *dependent* transcriptional activation of [CCND1] through a HDAC1 dependent mechanism . Regulation CCND1 EGFR 12612606 1063469 Importantly , Wnt transactivated was *responsible* for MAPK activation and the increased levels of [cyclin D1] present in the Wnt expressing HC11 cells . Regulation CCND1 EPCAM 19294417 2106046 Additionally , western blot was used to detect the *effect* of on cell cycle-relevant factor [cyclin D1] . Regulation CCND1 EPCAM 21785818 2476532 Nuclear localization of the cyclin D1 protein was observed in MCAs of HSC-4 cells but not in MCAs of EpCAM knockdown HSC4 cells , suggesting that *regulates* [cyclin D1] expression and localization in HSC-4 cells under anchorage independent conditions . Regulation CCND1 EPHB2 11498792 846709 Consistently , we show that the mediated FSH mitogenic *effect* triggers upregulation of [cyclin D1] . Regulation CCND1 EPHB2 11502738 868205 Taken together , these findings demonstrate that Ang II-induced [cyclin D1] up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a *dependent* manner , and also involves PI3K and SHP-2 . Regulation CCND1 EPHB2 12165850 972985 Differentiation induced by retinoic acid results in the gain of *dependent* control of [cyclin D1] expression and of S phase progression . Regulation CCND1 EPHB2 15033934 1237364 Taken together , our findings define a critical role for SAMe in signaling and [cyclin D1] *regulation* during regeneration and suggest chronic hepatic SAMe depletion results in loss of responsiveness to mitogenic signals . Regulation CCND1 EPHB2 15547725 1338350 Our data indicate that activated *plays* an important role in [cyclin D1] and Cdk-2 expression and phosphorylation of pRB at Ser780 and Ser795 in liver cancer cells . Regulation CCND1 EPHB2 15840582 1418288 Our studies reveal that recombinant MIF induces [cyclin D1] expression in a Rho- , Rho kinase- , MLC kinase- , and *dependent* manner in asynchronous NIH 3T3 fibroblasts . Regulation CCND1 EPHB2 17314399 1711560 activity *regulates* the induction of [cyclin D1] , and a sustained ERK signal is thought to be required for this effect , at least in fibroblasts . Regulation CCND1 EPHB2 17941827 1849412 Heregulin beta1 promotes breast cancer cell proliferation through *dependent* induction of [cyclin D1] and p21Cip1 . Regulation CCND1 EPHB2 18806267 1987337 HMW-HA binding to CD44 selectively inhibits the GTP loading of Rac and Rac dependent signaling to the cyclin D1 gene , whereas LMW-HA binding to CD44 selectively stimulates ERK activation and *dependent* [cyclin D1] gene expression . Regulation CCND1 EPHB2 22214150 2519151 It was found that and JNK were *involved* in silica induced [cyclin D1] and CDK4 overexpression and the decreased expression of E2F-4 . Regulation CCND1 ESR1 16945332 1615531 Consequently , we asked whether RFP would modulate ESR1 activity and we discovered that RFP was important for the *dependent* expression of [cyclin D1 (CCND1)] and the progesterone receptor (PR) , but not IRS1 or MYC . Regulation CCND1 FBXW8 17205132 1663888 A critical *role* for and MAPK in [cyclin D1] degradation and cancer cell proliferation . Regulation CCND1 FGF8 22465097 2595054 Several key regulators of early cell cycle progression such as Btg2 and [cyclin D1] , as well as regulators of mitosis , including cyclin B , Plk1 , survivin , and aurora kinase A , were identified as novel *targets* for , some of which were additionally shown to correlate with prognosis and ER status in human breast cancer . Regulation CCND1 FHL2 18378678 1912981 The LIM-only protein *regulates* [cyclin D1] expression and cell proliferation . Regulation CCND1 FHL2 19018287 1992045 We reported previously that *regulates* [cyclin D1] expression and that immortalized FHL2-null mouse embryo fibroblasts ( MEFs ) display reduced levels of cyclin D1 and low proliferative activity . Regulation CCND1 FLCN 23525507 2767020 *regulates* [cyclin D1] expression through cis acting elements in the 3 ' untranslated region of cyclin D1 mRNA . Regulation CCND1 FOSB 18413814 1894235 Furthermore , in flat ACF , EGFR blockade decreased the up-regulation of c-Jun , , phosphorylated active signal transducers and activators of transcription 3 , and CCAAT/enhancer binding protein-beta , potential *regulators* of [cyclin D1] and Cox-2 . Regulation CCND1 FOXO1 19938874 2190509 Furthermore , a luciferase assay demonstrated that could *regulate* the expression of [Ccnd1] at the transcription level . Regulation CCND1 FUT1 12588994 1059771 *regulates* accumulation of [cyclin D1] and cyclin D1-dependent protein kinase . Regulation CCND1 GDF15 22484283 2601601 MIC-1 induced expression of cyclins D1 and E was mediated by AP-1 and E2F-1 transcription factors , and among the AP-1 members , c-Jun and JunD appeared to participate in *dependent* transcription of the [cyclin D1] gene . Regulation CCND1 GGNBP2 17046823 1654493 In this study , we investigated the *effect* of on [cyclin D1] mutants ( R29Q , L32A , T286A , T288A , and T286A/T288A ) to clarify the precise mechanisms by which DIF-3 degrades cyclin D1 in HeLa cells . Regulation CCND1 GLA 19180667 2043821 The aim of this study was to investigate the *effects* of 150 muM on the expression of E2F1 , [cyclin D1] , bax , bcl2 , Ku70 , and Ku80 in C6 rat glioma cells . Regulation CCND1 GRAP2 10066798 593772 Optimal induction of [cyclin D1] by pp60 ( v-src ) *involved* the extracellular signal regulated kinase , , and c-Jun N-terminal kinase members of the mitogen activated protein kinase family . Regulation CCND1 GRAP2 10952989 744322 The *effect* of ( SAPK2 ) on [cyclin D1] stability might be mediated by direct phosphorylation at specific sites . Regulation CCND1 GRAP2 12763029 1093759 Therefore , we examined the *involvement* of MAPK signaling in AngII stimulated DNA synthesis , phosphorylation of the retinoblastoma protein ( Rb ) , and expression of the G1-phase [cyclin D1] in human coronary artery smooth muscle cells ( CASMC ) . Regulation CCND1 GRAP2 14729633 1198584 The reduced expression of [cyclin D1] protein was *independent* of the ( SAPK ) and phosphatidylinositol 3-kinase pathways , which are known regulators of cyclin D1 protein . Regulation CCND1 GRAP2 19080374 2003314 ERKs and JNKs , but not , are *responsible* for the decrease of [cyclin D1] and CDK4 protein expression level in HELF induced by quartz . Regulation CCND1 GSK3B 11124803 758649 *dependent* phosphorylation of [cyclin D1] at Thr-286 promotes the nuclear-to-cytoplasmic redistribution of cyclin D1 during S phase of the cell cycle , but how phosphorylation regulates redistribution has not been resolved . Regulation CCND1 GSK3B 12526086 1028226 Since is *involved* in [cyclin D1] proteolysis in response to mitogenic stimulation , PLCgamma1 mediated GSK-3beta phosphorylation may function as a regulation of cyclin D1 accumulation in PLCgamma1 overexpressing cells . Regulation CCND1 GSK3B 14612495 1163312 *dependent* phosphorylation of [cyclin D1] at a conserved COOH-terminal residue , Thr-286 , promotes CRM1 dependent cyclin D1 nuclear export at the G ( 1 ) -S boundary . Regulation CCND1 GSK3B 15513923 1347721 *dependent* phosphorylation of [cyclin D1] at a conserved C-terminal residue , Thr-286 , promotes CRM1 dependent cyclin D1 nuclear export . Regulation CCND1 GSK3B 15753396 1380170 Rapamycin treatment leads to an increase in the kinase activity of ( GSK3beta ) , a known *regulator* of [cyclin D1] proteolysis . Regulation CCND1 GSK3B 17046823 1654491 *Involvement* of and DYRK1B in differentiation inducing factor-3 induced phosphorylation of [cyclin D1] in HeLa cells . Regulation CCND1 GSK3B 18023328 1866878 *regulates* [cyclin D1] expression : a new target for chemotherapy . Regulation CCND1 GSK3B 19882709 2293564 These findings suggest that GSK-3beta is a differentiation fate determinant , and shed new lights on the mechanism by which *regulates* [cyclin D1] degradation and cellular differentiation in gliomas . Regulation CCND1 GSK3B 9832503 551863 *regulates* [cyclin D1] proteolysis and subcellular localization . Regulation CCND1 GTF2B 22264791 2545034 CREPT *regulates* [cyclin D1] expression by binding to its promoter , enhancing its transcription both in vivo and in vitro , and interacting with . Regulation CCND1 GTF2F1 22264791 2545035 CREPT *regulates* [cyclin D1] expression by binding to its promoter , enhancing its transcription both in vivo and in vitro , and interacting with . Regulation CCND1 GTF2F2 22264791 2545036 CREPT *regulates* [cyclin D1] expression by binding to its promoter , enhancing its transcription both in vivo and in vitro , and interacting with . Regulation CCND1 GTF2I 16314517 1487333 We further show that the transcriptional *regulation* of [cyclin D1] and cell cycle control by are dependent on its tyrosine phosphorylation at positions 248 and 611 , sites required for its growth signal mediated transcriptional activity . Regulation CCND1 GTPBP1 10444391 635975 Cyclin D1 expression on collagen film was inhibited by cytochalasin D and exoenzyme C3 , suggesting a *role* for the , Rho , in regulating [cyclin D1] expression . Regulation CCND1 GTPBP10 10444391 635973 Cyclin D1 expression on collagen film was inhibited by cytochalasin D and exoenzyme C3 , suggesting a *role* for the , Rho , in regulating [cyclin D1] expression . Regulation CCND1 GTPBP2 10444391 635976 Cyclin D1 expression on collagen film was inhibited by cytochalasin D and exoenzyme C3 , suggesting a *role* for the , Rho , in regulating [cyclin D1] expression . Regulation CCND1 GTPBP3 10444391 635970 Cyclin D1 expression on collagen film was inhibited by cytochalasin D and exoenzyme C3 , suggesting a *role* for the , Rho , in regulating [cyclin D1] expression . Regulation CCND1 GTPBP4 10444391 635971 Cyclin D1 expression on collagen film was inhibited by cytochalasin D and exoenzyme C3 , suggesting a *role* for the , Rho , in regulating [cyclin D1] expression . Regulation CCND1 GTPBP6 10444391 635974 Cyclin D1 expression on collagen film was inhibited by cytochalasin D and exoenzyme C3 , suggesting a *role* for the , Rho , in regulating [cyclin D1] expression . Regulation CCND1 GTPBP8 10444391 635972 Cyclin D1 expression on collagen film was inhibited by cytochalasin D and exoenzyme C3 , suggesting a *role* for the , Rho , in regulating [cyclin D1] expression . Regulation CCND1 GUCY2D 19086036 2041980 Lowering Mnt expression further enhanced 's inductive *effect* on p53 and [cyclin D1] . Regulation CCND1 HDAC1 12138206 969211 In addition , INI1/hSNF5 repressed transcription of [cyclin D1] gene in MON , in a *dependent* manner . Regulation CCND1 HDAC2 12138206 969212 In addition , INI1/hSNF5 repressed transcription of [cyclin D1] gene in MON , in a *dependent* manner . Regulation CCND1 HEXIM1 18757415 1956555 *regulates* 17beta-estradiol/estrogen receptor-alpha mediated expression of [cyclin D1] in mammary cells via modulation of P-TEFb . Regulation CCND1 HGF 24126105 2867927 Depletion of Gab1 , using siRNA , decreased the ERK and Akt activation , [cyclin D1] expression , and DNA synthesis in *response* to both EGF and . Regulation CCND1 HRAS 10531005 562000 *dependent* induction of [cyclin D1] expression beginning in G2 phase is critical for continuous cell cycle progression in NIH3T3 cells . Regulation CCND1 HRAS 10611246 656164 Induction of [cyclin D1] by NeuT *involved* , Rac , Rho , extracellular signal regulated kinase , c-Jun N-terminal kinase , and p38 , but not phosphatidylinositol 3-kinase . Regulation CCND1 HRAS 11502738 868206 Taken together , these findings demonstrate that Ang II-induced [cyclin D1] up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a *dependent* manner , and also involves PI3K and SHP-2 . Regulation CCND1 HRAS 12082537 958583 In exponentially growing cells , oncogenic had no *effect* on proliferation rates , Erk phosphorylation , or the level of [cyclin D1] , and Ras-induction did not confer serum independent growth . Regulation CCND1 HRAS 12202534 983090 The requirement for and the regulatory *role* of ERK2 in [cyclin D1] production and in cell proliferation suggest that the Ras/Raf/MEK/ERK pathway plays a key role in the control of RPE cell proliferation . Regulation CCND1 HRAS 12386817 999802 To understand the mechanism of the *dependent* [cyclin D1] induction , cyclin D1 mRNA levels were determined by quantitative image analysis following fluorescent in situ hybridization . Regulation CCND1 HRAS 18604165 1935599 However , more recent reports suggested that the commitment to cycle in response to serum occurs already in G ( 2 ) phase and requires the *dependent* induction of [cyclin D1] , which promotes following G ( 1 ) /S transition . Regulation CCND1 HRAS 7559524 323569 Site directed mutagenesis of AP-1-like sequences at -954 abolished *dependent* activation of [cyclin D1] expression . Regulation CCND1 HRG 18355957 1912644 Down-regulation of EBP1 expression in MCF-7 cells by shRNA resulted in increased cell growth in *response* to and increased [cyclin D1] and ErbB2 expression . Regulation CCND1 IFI27 11115553 768368 Insufficient *effect* of ( KIP1 ) to inhibit [cyclin D1] in human esophageal cancer in vitro . Regulation CCND1 IFI27 23268392 2709626 Treatment of the LPS challenged cells with QFTLR and benazepril both *resulted* in significantly attenuated expressions of [cyclin D1] , CDK2 , and P21 and obvious increase of expression ( P < 0.05 or P < 0.01 ) , but QFTLR produced stronger effects than benazepril in regulating of cyclinD1 , P21 and P27 protein expressions ( P < 0.05 or P < 0.01 ) . Regulation CCND1 IFNG 10022505 590087 To understand the antiproliferative signaling of IFNgamma , we studied the *effect* of on expression of c-Myc , Mad1 , Max , [cyclin D1] , and cyclin D2 genes in both a macrophage cell line and in primary bone marrow derived macrophages ( BMM ) in response to colony stimulating factor-1 (CSF-1) . Regulation CCND1 IGF1 10967123 751824 Estrogen was also able to potentiate the *effect* on the expression of [cyclin D1] and cyclin E and on the phosphorylation of retinoblastoma protein in control but not in SX13 cells . Regulation CCND1 IGF1 11376126 818173 Oestradiol can also potentiate the *effect* of on the expression of [cyclin D1] and cyclin E , and on the phosphorylation of the retinoblastoma protein ( RB ) . Regulation CCND1 IGF1 12867429 1141877 This latter result is explained by a delay in G1 to S cell cycle progression due partly to a reduction in the activation of some components of cell cycle including the induction of [cyclin D1] expression in *response* to . Regulation CCND1 IGF1 15580291 1368704 *Regulation* of [cyclin D1] expression by autocrine in human BON neuroendocrine tumour cells . Regulation CCND1 IGF1 15580291 1368706 Ras- and Rac-GTPases were found to be upstream activators of cyclin D1 expression , whereas protein kinase B/AKT and nuclear factor kappa B (NFkappaB) could be established as downstream mediators of [cyclin D1] transcription in *response* to endogenously released in these cells . Regulation CCND1 IGF1 15607540 1356953 Therefore , estrogen and differentially *regulate* c-Myc and [cyclin D1] to cooperatively stimulate breast cancer cell proliferation . Regulation CCND1 IGF1 16326831 1488433 The results showed that *dependent* phosphorylation of Akt and mitogen activated protein kinase , induction of G ( 1 ) -S-phase progression and enhanced expression of [cyclin D1] and cyclin E were dependent on ERalpha . Regulation CCND1 IGF1 16326831 1488453 Moreover , these same IGF-I induced responses were also inhibited by the antiestrogen ICI 182780 and this was in contrast to a previous report suggesting that ICI 182780 did not affect *dependent* activation of PI3-K or induction of [cyclin D1] expression . Regulation CCND1 IGF1 16397250 1506273 At doses that inhibited proliferation , the compound also caused a G0-G1 arrest and prevented nuclear accumulation of [cyclin D1] in *response* to LR3 . Regulation CCND1 IGF1 16408277 1540156 Here , we investigate *regulation* of laminin , an extracellular matrix (ECM) component , and [cyclin D1] and p21Cip1 , cell-cycle progression factor , expressions in glomerular mesangial cells . Regulation CCND1 IGF1 18403485 1925958 We found that cAMP pretreatment enhanced *dependent* increases in [cyclin D1] , due to synergistic increases in mRNA and elevation of translation rates . Regulation CCND1 IGF1 18505926 1917961 Characterization of a novel primary mammary tumor cell line reveals that [cyclin D1] is *regulated* by the type I receptor . Regulation CCND1 IGF1 19105244 2004130 Rapamycin also inhibited betacellulin- and induced entry of cells into S phase and 5'-Bromo-2'-deoxyuridine incorporation as well as the *effect* of betacellulin and IGF-I on [cyclin D1] expression and nuclear exclusion of p21 ( Cip1 ) and p(27Kip1) . Regulation CCND1 IGF1 19865540 2156737 It is presumed that estrogen and *regulate* c-Myc and [cyclin D1] during breast cancer cell proliferation . Regulation CCND1 IGF1 23278864 2865462 The proliferative *effects* of ( IGF-1 , 25 ng/ml ) on [ ( 3 ) H ] thymidine ( TdR ) incorporation into DNA and on [cyclin D1] protein expression of rumen epithelial cells were inhibited by PPP ( the inhibitor of type 1 IGF receptor ) ( p < 0.05 ) and ERK inhibitor ( p < 0.05 ) in vitro . Regulation CCND1 IGF1 23447091 2809697 To elucidate the mechanism of IGF-I actions on neural cell proliferation , we utilized a rat oligodendroglial cell line ( OL-1 ) and primary oligodendrocyte precursors ( OPC ) and studied *regulation* of [cyclin D1] expression and its promoter activity , because cyclin D1 is critical to the promotion of cell proliferation and cell cycle progression . Regulation CCND1 IGH 2426362 61727 We therefore evaluated the *role* of two possible region linked gene products in [BCL1] growth inhibition ; Regulation CCND1 IL4 9728041 530010 The *effect* of ( 50 ng/ml ) , PGE2 ( 1 microM ) , and forskolin ( 10 microM ) on [cyclin D1] protein expression in 10 % FBS stimulated human airway smooth muscle cells was also examined . Regulation CCND1 IL5 7756840 307524 Recombinant human IL-5 prepared by this procedure bound to the high-affinity IL-5 receptor present on an eosinophilic leukemia cell line and elicited a proliferative response in the *dependent* murine B-cell line [BCL1] . Regulation CCND1 IL6ST 17322172 1719826 IL-6 also induced [cyclin D1] expression in a time- and *dependent* manner in VSMCs . Regulation CCND1 IL7 21847632 2524254 Using Western blot , reverse transcriptase-PCR , Co-Immunoprecipitation , and Chromatin Immunoprecipitation , we investigated how *regulated* [cyclin D1] in vitro and in nude mice . Regulation CCND1 IL8 17606477 1768504 Using PC3 and DU145 cell lines , we sought to determine whether signaling *regulated* [cyclin D1] expression in androgen independent prostate cancer ( AIPC ) cells and to characterize the signaling pathways underpinning this response and that of IL-8 promoted proliferation . Regulation CCND1 IL8 17606477 1768511 Our results indicate that signaling ( a ) *regulates* [cyclin D1] expression at the level of translation , ( b ) regulates the activation of proteins associated with the translation of capped and 5'-oligopyrimidine tract transcripts , and ( c ) activates signal transduction pathways underpinning AIPC cell proliferation . Regulation CCND1 INS 11500498 868174 In contrast to its potentiating action , a direct mitogenic *effect* of in MCF-7 cells involves activation of phosphatidylinositol 3-kinase and increased expression of [cyclin D1] . Regulation CCND1 INS 15607540 1356954 Therefore , estrogen and differentially *regulate* c-Myc and [cyclin D1] to cooperatively stimulate breast cancer cell proliferation . Regulation CCND1 INS 19865540 2156738 It is presumed that estrogen and *regulate* c-Myc and [cyclin D1] during breast cancer cell proliferation . Regulation CCND1 IRF1 17409403 1722205 The data show that [cyclin D1] is a key *target* for mediated tumor-suppressive effects . Regulation CCND1 JAK2 19638583 2118635 We have recently reported that *controls* the expression and nuclear accumulation of [cyclin D1] . Regulation CCND1 JAK2 19638583 2118639 The constitutive activation of ErbB2 signaling , which is an initial event in the formation of mammary cancer , was able to override the functional *role* of in regulating the expression of Akt1 and [cyclin D1] . Regulation CCND1 JUN 10500157 648054 To interpret these results , we propose a mechanism in which heterodimers bind to the CRE-D1 element and *mediate* the activation of [cyclin D1] promoter by the ER . Regulation CCND1 JUN 16248432 1471665 We studied the *regulation* of [cyclinD1] by B heterodimers by laser scanning confocal influorescence microscopy , Western blot , luciferase activity assay , super-EMSA and flow cytometry in the Tet-on-LMP1 HNE2 cell line , in which LMP1 expression was regulated by Tet-on system . Regulation CCND1 JUN 16248432 1471671 B heterodimers induced by LMP1 could up *regulate* [cyclin D1] promoter activity and expression . Regulation CCND1 JUN 16652374 1598471 Unexpectedly , neither TAM67 or JNK inhibition , nor forced c-jun expression had a significant impact on cyclin D1 induction by PEITC , indicating that does not *play* an important role in [cyclin D1] induction by PEITC . Regulation CCND1 JUN 16987002 1617632 In mouse lung epithelial cells that express Nox1 , Nox2 , Nox4 , p22(phox) , p47(phox) , p67(phox) , and Noxo1 , overexpression of Nox1 delayed cell cycle withdrawal by maintaining *dependent* expression of [cyclin D1] in low serum conditions . Regulation CCND1 JUN 17482134 1738732 Activated is also *responsible* for elevated [cyclin D1] expression , which is frequently overexpressed in human melanoma . Regulation CCND1 JUN 17496887 1750861 Moreover , [cyclinD1] was induced by p73 expression in a *dependent* manner , and was required for p73 mediated cell survival . Regulation CCND1 JUN 18413814 1894236 Furthermore , in flat ACF , EGFR blockade decreased the up-regulation of , FosB , phosphorylated active signal transducers and activators of transcription 3 , and CCAAT/enhancer binding protein-beta , potential *regulators* of [cyclin D1] and Cox-2 . Regulation CCND1 JUN 18703151 1974171 was *responsible* for the decrease of CDK4 expression level , but not that of [cyclin D1] . Regulation CCND1 JUN 19080374 2003316 is *responsible* for the decrease of CDK4 expression level but not that of [cyclin D1] . Regulation CCND1 JUN 21135252 2377997 *regulates* [cyclin D1] and c-MYC transcription in an AKT dependent manner in response to mTOR inhibition : role of AIP4/Itch mediated JUNB degradation . Regulation CCND1 JUNB 16248432 1471666 We studied the *regulation* of [cyclinD1] by heterodimers by laser scanning confocal influorescence microscopy , Western blot , luciferase activity assay , super-EMSA and flow cytometry in the Tet-on-LMP1 HNE2 cell line , in which LMP1 expression was regulated by Tet-on system . Regulation CCND1 JUNB 16248432 1471672 heterodimers induced by LMP1 could up *regulate* [cyclin D1] promoter activity and expression . Regulation CCND1 KLF13 17245133 1704041 [Cyclin D1] was identified as a direct transcriptional *target* for that may account for the proliferation defects observed in embryos with downregulated KLF13 levels . Regulation CCND1 KLF15 22613989 2603846 Then we determined the *effects* of and its downstream target , cell cycle regulation factor E2F1 on the proliferation of mesangial cells and the expression of the positive acting cell cycle regulatory proteins , [cyclinD1] and CDK2 , by means of positive and negative interference experiments in cultured rat mesangial cells . Regulation CCND1 KRAS 10531005 562001 *dependent* induction of [cyclin D1] expression beginning in G2 phase is critical for continuous cell cycle progression in NIH3T3 cells . Regulation CCND1 KRAS 10611246 656165 Induction of [cyclin D1] by NeuT *involved* , Rac , Rho , extracellular signal regulated kinase , c-Jun N-terminal kinase , and p38 , but not phosphatidylinositol 3-kinase . Regulation CCND1 KRAS 12082537 958584 In exponentially growing cells , oncogenic had no *effect* on proliferation rates , Erk phosphorylation , or the level of [cyclin D1] , and Ras-induction did not confer serum independent growth . Regulation CCND1 KRAS 12202534 983091 The requirement for and the regulatory *role* of ERK2 in [cyclin D1] production and in cell proliferation suggest that the Ras/Raf/MEK/ERK pathway plays a key role in the control of RPE cell proliferation . Regulation CCND1 KRAS 12386817 999803 To understand the mechanism of the *dependent* [cyclin D1] induction , cyclin D1 mRNA levels were determined by quantitative image analysis following fluorescent in situ hybridization . Regulation CCND1 KRAS 15573917 1344515 In cell lines , it has been reported previously that beta-catenin and *play* the same roles in activation of [cyclin D1] transcription . Regulation CCND1 KRAS 18604165 1935600 However , more recent reports suggested that the commitment to cycle in response to serum occurs already in G ( 2 ) phase and requires the *dependent* induction of [cyclin D1] , which promotes following G ( 1 ) /S transition . Regulation CCND1 LEP 17344214 1726955 We also show specific involvement of coactivator molecules , histone acetyltransferase SRC1 , and mediator complex in mediated *regulation* of [CYCLIN D1] promoter . Regulation CCND1 LEP 22692856 2638676 *regulates* [cyclin D1] in luminal epithelial cells of mouse MMTV-Wnt-1 mammary tumors . Regulation CCND1 LGALS3 12439750 1016873 In this report , we investigated the *role* of on [cyclin D(1)] gene expression , a critical inducer of the cell cycle and a potential oncogene in human cancer . Regulation CCND1 LIN28A 22467868 2601332 Finally , using a combined gene expression microarray and bioinformatics approach , we found that also *regulates* [CCND1] and CDC25A expression and that this is mediated by inhibiting the biogenesis of let-7 miRNA . Regulation CCND1 MALT1 21911473 2496826 Collectively , these data reveal a requisite *role* for the SCF ( Fbx4 ) E3 in regulating [cyclin D1] accumulation , consistent with tumor suppressive function in vivo . Regulation CCND1 MAP2K1 11502738 868207 Taken together , these findings demonstrate that Ang II-induced [cyclin D1] up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a *dependent* manner , and also involves PI3K and SHP-2 . Regulation CCND1 MAP2K2 11502738 868208 Taken together , these findings demonstrate that Ang II-induced [cyclin D1] up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a *dependent* manner , and also involves PI3K and SHP-2 . Regulation CCND1 MAP2K3 11502738 868209 Taken together , these findings demonstrate that Ang II-induced [cyclin D1] up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a *dependent* manner , and also involves PI3K and SHP-2 . Regulation CCND1 MAP2K4 11502738 868210 Taken together , these findings demonstrate that Ang II-induced [cyclin D1] up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a *dependent* manner , and also involves PI3K and SHP-2 . Regulation CCND1 MAP2K5 11502738 868211 Taken together , these findings demonstrate that Ang II-induced [cyclin D1] up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a *dependent* manner , and also involves PI3K and SHP-2 . Regulation CCND1 MAP2K6 11502738 868212 Taken together , these findings demonstrate that Ang II-induced [cyclin D1] up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a *dependent* manner , and also involves PI3K and SHP-2 . Regulation CCND1 MAP2K7 11502738 868213 Taken together , these findings demonstrate that Ang II-induced [cyclin D1] up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a *dependent* manner , and also involves PI3K and SHP-2 . Regulation CCND1 MAP3K5 21187402 2378868 overexpression induced the transcription of cyclin D1 , through AP-1 activation , and ASK1 levels were *regulated* by [cyclin D1] , via the Rb-E2F pathway . Regulation CCND1 MAP3K7 10048449 592533 Western blot analysis demonstrates that the level of [cyclin D1] protein was *regulated* negatively by overexpression of . Regulation CCND1 MAPK1 12202534 983092 The requirement for Ras and the regulatory *role* of in [cyclin D1] production and in cell proliferation suggest that the Ras/Raf/MEK/ERK pathway plays a key role in the control of RPE cell proliferation . Regulation CCND1 MAPK1 12242655 990022 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Regulation CCND1 MAPK1 12763029 1093760 Therefore , we examined the *involvement* of p38 signaling in AngII stimulated DNA synthesis , phosphorylation of the retinoblastoma protein ( Rb ) , and expression of the G1-phase [cyclin D1] in human coronary artery smooth muscle cells ( CASMC ) . Regulation CCND1 MAPK1 12763029 1093799 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Regulation CCND1 MAPK1 15095291 1238481 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Regulation CCND1 MAPK1 17205132 1663890 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Regulation CCND1 MAPK1 18692155 2020195 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to *dependent* activation of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Regulation CCND1 MAPK1 7559524 323603 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized *dependent* induction of [cyclin D1] promoter activity . Regulation CCND1 MAPK10 12242655 990023 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Regulation CCND1 MAPK10 12763029 1093761 Therefore , we examined the *involvement* of p38 signaling in AngII stimulated DNA synthesis , phosphorylation of the retinoblastoma protein ( Rb ) , and expression of the G1-phase [cyclin D1] in human coronary artery smooth muscle cells ( CASMC ) . Regulation CCND1 MAPK10 12763029 1093800 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Regulation CCND1 MAPK10 15095291 1238482 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Regulation CCND1 MAPK10 17205132 1663891 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Regulation CCND1 MAPK10 18692155 2020196 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to *dependent* activation of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Regulation CCND1 MAPK10 7559524 323604 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized *dependent* induction of [cyclin D1] promoter activity . Regulation CCND1 MAPK11 10952989 744321 Osmotic stress regulates the stability of [cyclin D1] in a *dependent* manner . Regulation CCND1 MAPK11 12242655 990024 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Regulation CCND1 MAPK11 12763029 1093762 Therefore , we examined the *involvement* of p38 signaling in AngII stimulated DNA synthesis , phosphorylation of the retinoblastoma protein ( Rb ) , and expression of the G1-phase [cyclin D1] in human coronary artery smooth muscle cells ( CASMC ) . Regulation CCND1 MAPK11 12763029 1093801 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Regulation CCND1 MAPK11 15095291 1238483 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Regulation CCND1 MAPK11 17205132 1663892 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Regulation CCND1 MAPK11 18692155 2020197 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to *dependent* activation of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Regulation CCND1 MAPK11 7559524 323605 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized *dependent* induction of [cyclin D1] promoter activity . Regulation CCND1 MAPK12 12242655 990025 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Regulation CCND1 MAPK12 12763029 1093763 Therefore , we examined the *involvement* of p38 signaling in AngII stimulated DNA synthesis , phosphorylation of the retinoblastoma protein ( Rb ) , and expression of the G1-phase [cyclin D1] in human coronary artery smooth muscle cells ( CASMC ) . Regulation CCND1 MAPK12 12763029 1093802 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Regulation CCND1 MAPK12 15095291 1238484 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Regulation CCND1 MAPK12 17205132 1663893 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Regulation CCND1 MAPK12 18692155 2020198 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to *dependent* activation of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Regulation CCND1 MAPK12 7559524 323606 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized *dependent* induction of [cyclin D1] promoter activity . Regulation CCND1 MAPK13 12242655 990026 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Regulation CCND1 MAPK13 12763029 1093764 Therefore , we examined the *involvement* of p38 signaling in AngII stimulated DNA synthesis , phosphorylation of the retinoblastoma protein ( Rb ) , and expression of the G1-phase [cyclin D1] in human coronary artery smooth muscle cells ( CASMC ) . Regulation CCND1 MAPK13 12763029 1093803 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Regulation CCND1 MAPK13 15095291 1238485 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Regulation CCND1 MAPK13 17205132 1663894 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Regulation CCND1 MAPK13 18692155 2020199 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to *dependent* activation of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Regulation CCND1 MAPK13 7559524 323607 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized *dependent* induction of [cyclin D1] promoter activity . Regulation CCND1 MAPK14 12242655 990027 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Regulation CCND1 MAPK14 12763029 1093765 Therefore , we examined the *involvement* of p38 signaling in AngII stimulated DNA synthesis , phosphorylation of the retinoblastoma protein ( Rb ) , and expression of the G1-phase [cyclin D1] in human coronary artery smooth muscle cells ( CASMC ) . Regulation CCND1 MAPK14 12763029 1093804 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Regulation CCND1 MAPK14 15095291 1238486 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Regulation CCND1 MAPK14 17205132 1663895 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Regulation CCND1 MAPK14 18692155 2020200 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to *dependent* activation of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Regulation CCND1 MAPK14 7559524 323608 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized *dependent* induction of [cyclin D1] promoter activity . Regulation CCND1 MAPK15 12242655 990021 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Regulation CCND1 MAPK15 12763029 1093758 Therefore , we examined the *involvement* of p38 signaling in AngII stimulated DNA synthesis , phosphorylation of the retinoblastoma protein ( Rb ) , and expression of the G1-phase [cyclin D1] in human coronary artery smooth muscle cells ( CASMC ) . Regulation CCND1 MAPK15 12763029 1093798 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Regulation CCND1 MAPK15 15095291 1238480 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Regulation CCND1 MAPK15 17205132 1663889 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Regulation CCND1 MAPK15 18692155 2020194 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to *dependent* activation of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Regulation CCND1 MAPK15 7559524 323602 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized *dependent* induction of [cyclin D1] promoter activity . Regulation CCND1 MAPK3 12242655 990028 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Regulation CCND1 MAPK3 12763029 1093766 Therefore , we examined the *involvement* of p38 signaling in AngII stimulated DNA synthesis , phosphorylation of the retinoblastoma protein ( Rb ) , and expression of the G1-phase [cyclin D1] in human coronary artery smooth muscle cells ( CASMC ) . Regulation CCND1 MAPK3 12763029 1093805 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Regulation CCND1 MAPK3 15095291 1238487 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Regulation CCND1 MAPK3 16522741 1531499 Although EX induced phosphorylation of Raf-1 and extracellular-signal regulated kinase ( ERK ) , both PD98059 and exogenous had no *effect* on the [cyclin D1] induction by EX . Regulation CCND1 MAPK3 17205132 1663896 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Regulation CCND1 MAPK3 18692155 2020201 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to *dependent* activation of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Regulation CCND1 MAPK3 20080131 2218719 We further show that IKKalpha dependent downregulation of Cyclin D1 expression in the UVB response results from the reduction of *dependent* [Cyclin D1] transcription coupled with an increase of p38 kinase dependent Cyclin D1 proteolysis . Regulation CCND1 MAPK3 7559524 323609 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized *dependent* induction of [cyclin D1] promoter activity . Regulation CCND1 MAPK3 8702807 376060 [Cyclin D1] expression is *regulated* positively by the and negatively by the p38/HOGMAPK pathway . Regulation CCND1 MAPK4 12242655 990029 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Regulation CCND1 MAPK4 12763029 1093767 Therefore , we examined the *involvement* of p38 signaling in AngII stimulated DNA synthesis , phosphorylation of the retinoblastoma protein ( Rb ) , and expression of the G1-phase [cyclin D1] in human coronary artery smooth muscle cells ( CASMC ) . Regulation CCND1 MAPK4 12763029 1093806 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Regulation CCND1 MAPK4 15095291 1238488 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Regulation CCND1 MAPK4 17205132 1663897 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Regulation CCND1 MAPK4 18692155 2020202 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to *dependent* activation of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Regulation CCND1 MAPK4 7559524 323610 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized *dependent* induction of [cyclin D1] promoter activity . Regulation CCND1 MAPK6 12242655 990030 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Regulation CCND1 MAPK6 12763029 1093768 Therefore , we examined the *involvement* of p38 signaling in AngII stimulated DNA synthesis , phosphorylation of the retinoblastoma protein ( Rb ) , and expression of the G1-phase [cyclin D1] in human coronary artery smooth muscle cells ( CASMC ) . Regulation CCND1 MAPK6 12763029 1093807 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Regulation CCND1 MAPK6 15095291 1238489 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Regulation CCND1 MAPK6 17205132 1663898 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Regulation CCND1 MAPK6 18692155 2020203 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to *dependent* activation of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Regulation CCND1 MAPK6 7559524 323611 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized *dependent* induction of [cyclin D1] promoter activity . Regulation CCND1 MAPK7 12242655 990031 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Regulation CCND1 MAPK7 12763029 1093769 Therefore , we examined the *involvement* of p38 signaling in AngII stimulated DNA synthesis , phosphorylation of the retinoblastoma protein ( Rb ) , and expression of the G1-phase [cyclin D1] in human coronary artery smooth muscle cells ( CASMC ) . Regulation CCND1 MAPK7 12763029 1093808 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Regulation CCND1 MAPK7 15095291 1238490 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Regulation CCND1 MAPK7 17205132 1663899 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Regulation CCND1 MAPK7 18692155 2020204 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to *dependent* activation of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Regulation CCND1 MAPK7 7559524 323612 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized *dependent* induction of [cyclin D1] promoter activity . Regulation CCND1 MAPK8 12242655 990032 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Regulation CCND1 MAPK8 12763029 1093770 Therefore , we examined the *involvement* of p38 signaling in AngII stimulated DNA synthesis , phosphorylation of the retinoblastoma protein ( Rb ) , and expression of the G1-phase [cyclin D1] in human coronary artery smooth muscle cells ( CASMC ) . Regulation CCND1 MAPK8 12763029 1093809 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Regulation CCND1 MAPK8 15095291 1238491 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Regulation CCND1 MAPK8 17205132 1663900 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Regulation CCND1 MAPK8 18692155 2020205 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to *dependent* activation of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Regulation CCND1 MAPK8 7559524 323613 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized *dependent* induction of [cyclin D1] promoter activity . Regulation CCND1 MAPK9 12242655 990033 PI3K signalling also participated in cell cycle progression , since PI3K and coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Regulation CCND1 MAPK9 12763029 1093771 Therefore , we examined the *involvement* of p38 signaling in AngII stimulated DNA synthesis , phosphorylation of the retinoblastoma protein ( Rb ) , and expression of the G1-phase [cyclin D1] in human coronary artery smooth muscle cells ( CASMC ) . Regulation CCND1 MAPK9 12763029 1093810 The present study demonstrates that p38 negatively *regulates* AngII induced ERK1/2 activity , Rb phosphorylation , [cyclin D1] expression , and DNA-synthesis in human CASMC . Regulation CCND1 MAPK9 15095291 1238492 We further show that conditional expression of MKP-3-GFP in this fibroblast cell line results in the inhibition of : ( a ) the phosphorylation of the p42/p44 MAPK substrates Elk1 and HIF-1alpha , ( b ) vascular endothelial growth factor ( VEGF ) , [cyclin D1] , and c-fos gene transcription in *response* to pathway activation , and ( c ) cell proliferation . Regulation CCND1 MAPK9 17205132 1663901 A critical *role* for FBXW8 and in [cyclin D1] degradation and cancer cell proliferation . Regulation CCND1 MAPK9 18692155 2020206 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to *dependent* activation of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Regulation CCND1 MAPK9 7559524 323614 Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ) , antagonized *dependent* induction of [cyclin D1] promoter activity . Regulation CCND1 MAPKAP1 24626091 2934220 Notably , selective inhibition of mTORC2 triggered proteasome mediated cyclin D1 degradation , suggesting that blockade is *responsible* for GSK3 dependent reduction of [cyclin D1] . Regulation CCND1 MAX 19086036 2041970 The current work tested the hypothesis that the switch from Mnt-Max to is *responsible* for p53 and [cyclin D1] up-regulation and apoptosis during cholestasis . Regulation CCND1 ME2 15691880 1371472 <2-ME2> had no significant *effect* on [cyclin D1] ; Regulation CCND1 MIF 19938192 2167579 To investigate the *effects* of ( MIF ) on proliferation of human gastric cancer MGC-803 cells and expression of [cyclin D1] and p27 ( Kip1 ) in them , and further determine whether the effects are related to the PI3K/Akt signal transduction pathway . Regulation CCND1 MIR193B 20304954 2254853 represses cell proliferation and *regulates* [cyclin D1] in melanoma . Regulation CCND1 MIR200B 20683643 2329485 *regulates* [cyclin D1] expression and promotes S-phase entry by targeting RND3 in HeLa cells . Regulation CCND1 MLST8 19225536 2054551 As is activated in MCL and may *control* [cyclin D1] levels , we show that p53 activation may downregulate the AKT/mTOR pathway through a mechanism involving AMP kinase (AMPK) . Regulation CCND1 MLST8 24626091 2934221 Notably , selective inhibition of mTORC2 triggered proteasome mediated cyclin D1 degradation , suggesting that blockade is *responsible* for GSK3 dependent reduction of [cyclin D1] . Regulation CCND1 MNT 19086036 2041971 The current work tested the hypothesis that the switch from to Myc-Max is *responsible* for p53 and [cyclin D1] up-regulation and apoptosis during cholestasis . Regulation CCND1 MTOR 18339899 1904992 Intriguingly , inhibition *affected* [cyclin D1] proteolysis only in MCL cells in which GSK-3 is under the direct control of mTOR , suggesting that different MCL subsets could be differently responsive to mTOR inhibition . Regulation CCND1 MTOR 19225536 2054553 As is activated in MCL and may *control* [cyclin D1] levels , we show that p53 activation may downregulate the AKT/mTOR pathway through a mechanism involving AMP kinase (AMPK) . Regulation CCND1 MTOR 21135252 2377996 AP-1 regulates [cyclin D1] and c-MYC transcription in an AKT dependent manner in *response* to inhibition : role of AIP4/Itch mediated JUNB degradation . Regulation CCND1 MTOR 23291002 2752440 Since Akt functions as an upstream activator of mechanistic target of rapamycin complex 1 ( mTORC1 ) and is also a downstream target for mTORC2 , the aim of this work was to determine whether is *involved* in thrombin induced RPE cell proliferation by regulating [cyclin D1] expression in immortalized rat RPE-J cell line . Regulation CCND1 MTOR 24626091 2934223 Notably , selective inhibition of mTORC2 triggered proteasome mediated cyclin D1 degradation , suggesting that blockade is *responsible* for GSK3 dependent reduction of [cyclin D1] . Regulation CCND1 MUC1 24979278 2947636 *regulates* [cyclin D1] gene expression through p120 catenin and ß-catenin . Regulation CCND1 MUC1 24979278 2947638 We investigated the *effect* of overexpressing on the regulation of [cyclin D1] , a downstream target for the WNT/ß-catenin signaling pathway , in two human pancreatic cancer cell lines , Panc-1 and S2-013 . Regulation CCND1 MYBL2 15922873 1413858 *Regulation* of the [cyclin D1] and cyclin A1 promoters by is mediated by Sp1 binding sites . Regulation CCND1 MYBL2 15922873 1413860 Previous work has suggested that the [cyclin D1] gene might be *regulated* by . Regulation CCND1 MYC 19086036 2041972 The current work tested the hypothesis that the switch from Mnt-Max to is *responsible* for p53 and [cyclin D1] up-regulation and apoptosis during cholestasis . Regulation CCND1 MYC 19143767 2026110 down-regulation *affects* [cyclin D1/cdk4] activity and induces apoptosis via Smac/Diablo pathway in an astrocytoma cell line . Regulation CCND1 MYLIP 18483394 1939097 This study introduces the *role* of in the regulation of [CCND1] in MCL . Regulation CCND1 MYLIP 20133739 2213547 In conclusion , we demonstrated that *plays* an important role in the flow regulation of [cyclin D1] expression . Regulation CCND1 MYLIP 20304954 2254855 A luciferase reporter assay confirmed that directly *regulates* [CCND1] by binding to the 3'untranslated region of CCND1 mRNA . Regulation CCND1 MYLIP 20304954 2254857 These studies indicate that represses cell proliferation and *regulates* [CCND1] expression and suggest that dysregulation of miR-193b may play an important role in melanoma development . Regulation CCND1 MYLIP 21893020 2496533 In a previous study , we reported that represses cell proliferation and *regulates* [cyclin D1] in melanoma cells , suggesting that miR-193b could act as a tumor suppressor . Regulation CCND1 MYLIP 22912826 2657482 expression inhibited cell proliferation in LO2/HBx-d382 cells ( and LO2/HBx cells ) , and also negatively *regulated* [CyclinD1] protein expression . Regulation CCND1 MYLIP 22912826 2657484 can directly *regulate* [CyclinD1] expression through binding to the CyclinD1-3'UTR region , mainly at nt 2397-2403 . Regulation CCND1 MYLIP 23991964 2836650 At the molecular level , our results further revealed that [cyclin D1] expression was negatively *regulated* by . Regulation CCND1 MYLIP 25111862 2954408 Finally , we demonstrate that [cyclin D1] is *regulated* by in PrEC but not in PCa cells and this is due to the absence of a CCND1 3'-UTR in these cells . Regulation CCND1 NCK1 21719533 2471263 *regulates* [cyclin D1] promoter activity in response to prolactin . Regulation CCND1 NCOA1 22542550 2631166 We studied the *role* of PR and in the expression of VEGF , EGFR and [cyclin D1] mediated by P in human astrocytoma cell lines grade III ( U373 ) and IV ( D54 ) . Regulation CCND1 NDRG1 23897809 2839722 In addition , we found that did not *affect* the kinase activity of [cyclin D1/Cdk4] upon phosphorylation of GST-Rb . Regulation CCND1 NFATC1 19933579 2198181 In addition to its role in cell cycle progression , [cyclin D1] mediated HASMC migration in an *dependent* manner . Regulation CCND1 NFATC4 16645724 1583383 These results indicate that ionizing radiation is able to enhance cyclin D1 transcription induced by B [ a ] PDE , and is *involved* in the regulation of [cyclin D1] transcription by B [ a ] PDE or B [ a ] PDE plus ionizing radiation . Regulation CCND1 NFKB1 10409765 630557 *regulation* of [cyclin D1] occurs at the transcriptional level and is mediated by direct binding of NF-kappaB to multiple sites in the cyclin D1 promoter . Regulation CCND1 NFKB1 10523665 653571 Finally , we have observed that Dbl and Dbs regulated transcription from the [cyclin D1] promoter in a *dependent* manner . Regulation CCND1 NFKB1 15489214 1321284 The biological effect of Ganoderma lucidum was demonstrated by cell cycle arrest at G0/G1 , which was the result of the downregulation of expression of *regulated* [cyclin D1] , followed by the inhibition of cdk4 . Regulation CCND1 NFKB1 15652748 1364322 Mechanistically , the effects of Vav1 require its GEF activity and the activation of Rac1 , PAK1 , and and *involve* [cyclin D1] upregulation . Regulation CCND1 NFKB1 15811958 1425066 The *regulated* gene products [cyclin D1] , cyclooxygenase-2 (COX-2) , matrix metalloproteinase-9 (MMP-9) , survivin , inhibitor-of-apoptosis protein-1 (IAP1) , IAP2 , X chromosome linked IAP (XIAP) , Bcl-2 , Bfl-1/A1 , TNF receptor associated factor-1 (TRAF1) , and Fas associated death domain protein-like interleukin-1beta converting enzyme inhibitory protein ( FLIP ) were all down-regulated by indole-3-carbinol . Regulation CCND1 NFKB1 16759223 1631483 AP1 and cAMP response element ( CRE ) , but not , were *involved* in the induced [cyclin D1] expression . Regulation CCND1 NFKB1 17404108 1721548 Vitamin K2 also suppressed the binding site *dependent* [cyclin D1] promoter activity and suppressed the basal , 12-O-tetradecanoylphorbol-13-acetate ( TPA ) - , TNF-alpha- , and interleukin (IL)-1 induced activation of NF-kappaB binding and transactivation . Regulation CCND1 NFKB1 17440100 1729503 P = 0.036 versus gemcitabine alone ) , Ki-67 proliferation index ( P = 0.030 versus control ) , NF-kappaB activation , and expression of *regulated* gene products ( [cyclin D1] , c-myc , Bcl-2 , Bcl-xL , cellular inhibitor of apoptosis protein-1 , cyclooxygenase-2 , matrix metalloproteinase , and vascular endothelial growth factor ) compared with tumors from control mice treated with olive oil only . Regulation CCND1 NFKB1 17522064 1778354 The suppression of NF-kappaB activity correlated with inhibition of NF-kappaB reporter activity and with down-regulation of cyclooxygenase-2 , [cyclin D1] and vascular endothelial growth factor , all *regulated* by . Regulation CCND1 NFKB1 19623659 2131231 This effect was accompanied by suppressed expression of activated NF-kappaB and *regulated* gene products ( [cyclin D1] , c-myc , bcl-2 , bcl-xL , cIAP-1 , COX-2 , ICAM-1 , MMP-9 , CXCR4 and VEGF ) . Regulation CCND1 NGF 18367547 1912793 *regulation* of [cyclin D1] in PC12 cells through a p21RAS extracellular signal regulated kinase pathway requires cooperative interactions between Sp1 and nuclear factor-kappaB . Regulation CCND1 NOTCH1 20887720 2343259 In conclusion , the data define a novel temporal context dependent function of and a critical *role* for [cyclin D1] in the Notch induced proliferation in ES cells . Regulation CCND1 NOTCH2 20887720 2343260 In conclusion , the data define a novel temporal context dependent function of and a critical *role* for [cyclin D1] in the Notch induced proliferation in ES cells . Regulation CCND1 NOTCH3 20887720 2343261 In conclusion , the data define a novel temporal context dependent function of and a critical *role* for [cyclin D1] in the Notch induced proliferation in ES cells . Regulation CCND1 NOTCH4 20887720 2343262 In conclusion , the data define a novel temporal context dependent function of and a critical *role* for [cyclin D1] in the Notch induced proliferation in ES cells . Regulation CCND1 NOX1 23706097 2878208 Expression of Sod2 , Nrf2 , and [cyclin D1] and phosphorylation of cofilin and Erk were *dependent* . Regulation CCND1 NOX1 23864022 2817529 Genetic inactivation of Hace1 in mice or zebrafish , as well as Hace1 loss in human tumor cell lines or primary murine or human tumors , leads to chronic *dependent* reactive oxygen species elevation , DNA damage responses and enhanced [cyclin D1] expression . Regulation CCND1 NOX3 23864022 2817530 Genetic inactivation of Hace1 in mice or zebrafish , as well as Hace1 loss in human tumor cell lines or primary murine or human tumors , leads to chronic *dependent* reactive oxygen species elevation , DNA damage responses and enhanced [cyclin D1] expression . Regulation CCND1 NOX4 23864022 2817531 Genetic inactivation of Hace1 in mice or zebrafish , as well as Hace1 loss in human tumor cell lines or primary murine or human tumors , leads to chronic *dependent* reactive oxygen species elevation , DNA damage responses and enhanced [cyclin D1] expression . Regulation CCND1 NOX5 23864022 2817528 Genetic inactivation of Hace1 in mice or zebrafish , as well as Hace1 loss in human tumor cell lines or primary murine or human tumors , leads to chronic *dependent* reactive oxygen species elevation , DNA damage responses and enhanced [cyclin D1] expression . Regulation CCND1 NQO2 22266466 2564856 Our results indicate a hitherto unreported *role* of in the control of [AKT/GSK-3ß/cyclin D1] and highlight the involvement of NQO2 in degradation of cyclin D1 , as part of mechanism of chemoprevention by resveratrol . Regulation CCND1 NR0B1 23118901 2696029 GLT treatment also significantly down-regulated *dependent* expression of [cyclin D1] , COX-2 , CYP1A2 and CYP3A4 in colon tissue . Regulation CCND1 NR1I3 16322332 1487939 Finally , the inhibitory *effects* of and BAY11-7082 on [cyclin D1] expression were not additive - by blocking NF-kappaB CaR activation did not induce a further reduction in cyclin D1 levels . Regulation CCND1 NRAS 10531005 562002 *dependent* induction of [cyclin D1] expression beginning in G2 phase is critical for continuous cell cycle progression in NIH3T3 cells . Regulation CCND1 NRAS 10611246 656166 Induction of [cyclin D1] by NeuT *involved* , Rac , Rho , extracellular signal regulated kinase , c-Jun N-terminal kinase , and p38 , but not phosphatidylinositol 3-kinase . Regulation CCND1 NRAS 12082537 958585 In exponentially growing cells , oncogenic had no *effect* on proliferation rates , Erk phosphorylation , or the level of [cyclin D1] , and Ras-induction did not confer serum independent growth . Regulation CCND1 NRAS 12202534 983093 The requirement for and the regulatory *role* of ERK2 in [cyclin D1] production and in cell proliferation suggest that the Ras/Raf/MEK/ERK pathway plays a key role in the control of RPE cell proliferation . Regulation CCND1 NRAS 12386817 999804 To understand the mechanism of the *dependent* [cyclin D1] induction , cyclin D1 mRNA levels were determined by quantitative image analysis following fluorescent in situ hybridization . Regulation CCND1 NRAS 18604165 1935601 However , more recent reports suggested that the commitment to cycle in response to serum occurs already in G ( 2 ) phase and requires the *dependent* induction of [cyclin D1] , which promotes following G ( 1 ) /S transition . Regulation CCND1 NUP43 8702807 376059 [Cyclin D1] expression is *regulated* positively by the and negatively by the p38/HOGMAPK pathway . Regulation CCND1 PAK1 14530270 1185886 Together , these findings suggest a model wherein *regulation* of [cyclin D1] expression might involve an NF-kappaB dependent pathway and that hyperplasia in the mammary glands of Pak1-TG mice may be associated , at least in part , with the up-regulation of cyclin D1 , and that Pak1 is up-regulated in human breast tumors . Regulation CCND1 PAK1 15652748 1364323 Mechanistically , the effects of Vav1 require its GEF activity and the activation of Rac1 , , and NF-kappaB and *involve* [cyclin D1] upregulation . Regulation CCND1 PAK1 21719533 2471264 *regulates* [cyclin D1] promoter activity in response to prolactin . Regulation CCND1 PAK1 21719533 2471299 We have found that adapter protein Nck sequesters PAK1 in the cytoplasm and that coexpression of both PAK1 and Nck inhibits the amplifying *effect* of PRL induced on [cyclin D1] promoter activity ( 95 % inhibition ) . Regulation CCND1 PC 15201435 1281126 [Cyclin D1] protein levels were not *affected* by . Regulation CCND1 PHIP 23118901 2696028 GLT treatment also significantly down-regulated *dependent* expression of [cyclin D1] , COX-2 , CYP1A2 and CYP3A4 in colon tissue . Regulation CCND1 PI3 11017907 737640 Together , these data suggest that in airway smooth muscle ( ASM ) cells , *regulates* transcription from the [cyclin D(1)] promoter and DNA synthesis in an ERK independent manner . Regulation CCND1 PIK3C3 12124352 965755 Herceptin induced inhibition of and Akt Is required for antibody mediated *effects* on p27 , [cyclin D1] , and antitumor action . Regulation CCND1 PIK3CA 10611246 656167 Induction of [cyclin D1] by NeuT *involved* Ras , Rac , Rho , extracellular signal regulated kinase , c-Jun N-terminal kinase , and p38 , but not . Regulation CCND1 PIK3CA 10927622 762524 Since transcriptional activation of the [cyclin D1] promoter by EGF , E2 and TPA is *independent* of activity , these findings suggest a post-transcriptional role for PI3-K in the regulation of cyclin D1 expression . Regulation CCND1 PIK3CA 11502738 868214 Taken together , these findings demonstrate that Ang II-induced [cyclin D1] up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a p21(ras)/Raf-1/MEK/ERK dependent manner , and also *involves* and SHP-2 . Regulation CCND1 PIK3CA 12242655 990034 PI3K signalling also participated in cell cycle progression , since and MAPK coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Regulation CCND1 PIK3CA 12589056 1059887 *dependent* induction of [cyclin D1] was blocked by inhibitors of PI3K/Akt/IkappaB/IKKalpha or beta-catenin signaling . Regulation CCND1 PIK3CA 12907754 1157472 Moreover , we show that both and c-Src/Fak/Erk1/2 pathways are *involved* in the up-regulation of c-myc and [cyclin d1] expression mediated by PRL . Regulation CCND1 PIK3CA 18434386 1932576 These data reveal that Src is a crucial mediator of RPTC proliferation and Src mediated proliferation is associated with *dependent* upregulation of [cyclin D1] and PI3K independent downregulation of p27 and p57 . Regulation CCND1 PIK3CA 20724534 2306870 These findings demonstrate for the first time that *dependent* [cyclin D1] activation plays an essential role in HDL induced EPC proliferation , migration and angiogenesis . Regulation CCND1 PIK3R1 10611246 656168 Induction of [cyclin D1] by NeuT *involved* Ras , Rac , Rho , extracellular signal regulated kinase , c-Jun N-terminal kinase , and p38 , but not . Regulation CCND1 PIK3R1 10927622 762525 Since transcriptional activation of the [cyclin D1] promoter by EGF , E2 and TPA is *independent* of activity , these findings suggest a post-transcriptional role for PI3-K in the regulation of cyclin D1 expression . Regulation CCND1 PIK3R1 11502738 868215 Taken together , these findings demonstrate that Ang II-induced [cyclin D1] up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a p21(ras)/Raf-1/MEK/ERK dependent manner , and also *involves* and SHP-2 . Regulation CCND1 PIK3R1 12242655 990035 PI3K signalling also participated in cell cycle progression , since and MAPK coordinately *regulated* changes in [cyclin D1] and cdk6 expression . Regulation CCND1 PIK3R1 12589056 1059888 *dependent* induction of [cyclin D1] was blocked by inhibitors of PI3K/Akt/IkappaB/IKKalpha or beta-catenin signaling . Regulation CCND1 PIK3R1 12907754 1157473 Moreover , we show that both and c-Src/Fak/Erk1/2 pathways are *involved* in the up-regulation of c-myc and [cyclin d1] expression mediated by PRL . Regulation CCND1 PIK3R1 18434386 1932577 These data reveal that Src is a crucial mediator of RPTC proliferation and Src mediated proliferation is associated with *dependent* upregulation of [cyclin D1] and PI3K independent downregulation of p27 and p57 . Regulation CCND1 PIK3R1 20724534 2306871 These findings demonstrate for the first time that *dependent* [cyclin D1] activation plays an essential role in HDL induced EPC proliferation , migration and angiogenesis . Regulation CCND1 PIK3R4 12124352 965756 Herceptin induced inhibition of and Akt Is required for antibody mediated *effects* on p27 , [cyclin D1] , and antitumor action . Regulation CCND1 PIN1 15095272 1238370 This study aimed to elucidate whether was *involved* in [cyclin D1] overexpression and aberrant beta-catenin in thyroid tumourigenesis by examining 14 follicular adenomas (FAa) and 14 papillary thyroid carcinomas ( PTCs ) . Regulation CCND1 PIN1 16820873 1581576 Here , we investigated the *role* of in association with [cyclinD1] in esophageal SCC progression and its clinicopathological significance . Regulation CCND1 PIN1 16865248 1592733 In this study , whether is *involved* in cervical oncogenesis by regulating [cyclin D1] was explored and the potential of Pin1 targeted gene silencing in inhibiting cellular growth and tumorigenicity in cervical cancer was investigated . Regulation CCND1 PIN1 16865248 1592735 The results showed that directly *regulated* [cyclin D1] levels . Regulation CCND1 PIN1 16865250 1592738 The aims of this study were to investigate the expression levels of beta-catenin , Pin1 and cyclin D1 in salivary adenoid cystic carcinomas ( SACC ) and to evaluate its clinical importance , furthermore , to elucidate whether beta-catenin expression was aberrant in SACC and whether was *involved* in aberrant beta-catenin and [cyclin D1] expression . Regulation CCND1 PITX2 12629224 1067348 Here , we report that , in response to the Wntbeta-catenin pathway and growth signals , also can *regulate* c-Myc and [cyclin D1] . Regulation CCND1 PKN1 14530270 1185885 Results from deletion and mutant analysis indicate that *regulates* [cyclin D1] transcription by means of an NF-kappaB dependent pathway . Regulation CCND1 PLD1 11027278 738781 Ral activation of these responses is likely through an as yet uncharacterized effector pathway , as we find activation of NF-kappaB and the [cyclin D1] promoter by Ral is *independent* of association of Ral with active or Ral binding protein 1 , two proteins proposed to mediate Ral function in cells . Regulation CCND1 POLDIP2 10611246 656163 Induction of [cyclin D1] by NeuT *involved* Ras , Rac , Rho , extracellular signal regulated kinase , c-Jun N-terminal kinase , and , but not phosphatidylinositol 3-kinase . Regulation CCND1 POLDIP2 18692155 2020193 A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to *dependent* activation of mTOR and [cyclinD1] expression in prostate and lung cancer cells . Regulation CCND1 POLDIP2 20080131 2218718 We further show that IKKalpha dependent downregulation of Cyclin D1 expression in the UVB response results from the reduction of ERK1/2 dependent Cyclin D1 transcription coupled with an increase of kinase *dependent* [Cyclin D1] proteolysis . Regulation CCND1 POLR2A 22264791 2545037 CREPT *regulates* [cyclin D1] expression by binding to its promoter , enhancing its transcription both in vivo and in vitro , and interacting with . Regulation CCND1 POLR2B 22264791 2545038 CREPT *regulates* [cyclin D1] expression by binding to its promoter , enhancing its transcription both in vivo and in vitro , and interacting with . Regulation CCND1 POLR2C 22264791 2545039 CREPT *regulates* [cyclin D1] expression by binding to its promoter , enhancing its transcription both in vivo and in vitro , and interacting with . Regulation CCND1 POLR2D 22264791 2545040 CREPT *regulates* [cyclin D1] expression by binding to its promoter , enhancing its transcription both in vivo and in vitro , and interacting with . Regulation CCND1 POLR2E 22264791 2545041 CREPT *regulates* [cyclin D1] expression by binding to its promoter , enhancing its transcription both in vivo and in vitro , and interacting with . Regulation CCND1 POLR2F 22264791 2545042 CREPT *regulates* [cyclin D1] expression by binding to its promoter , enhancing its transcription both in vivo and in vitro , and interacting with . Regulation CCND1 POLR2G 22264791 2545043 CREPT *regulates* [cyclin D1] expression by binding to its promoter , enhancing its transcription both in vivo and in vitro , and interacting with . Regulation CCND1 POLR2H 22264791 2545044 CREPT *regulates* [cyclin D1] expression by binding to its promoter , enhancing its transcription both in vivo and in vitro , and interacting with . Regulation CCND1 POLR2I 22264791 2545045 CREPT *regulates* [cyclin D1] expression by binding to its promoter , enhancing its transcription both in vivo and in vitro , and interacting with . Regulation CCND1 POLR2J 22264791 2545046 CREPT *regulates* [cyclin D1] expression by binding to its promoter , enhancing its transcription both in vivo and in vitro , and interacting with . Regulation CCND1 POLR2K 22264791 2545047 CREPT *regulates* [cyclin D1] expression by binding to its promoter , enhancing its transcription both in vivo and in vitro , and interacting with . Regulation CCND1 POLR2L 22264791 2545048 CREPT *regulates* [cyclin D1] expression by binding to its promoter , enhancing its transcription both in vivo and in vitro , and interacting with . Regulation CCND1 POU5F1 25128069 2957238 In this study , the wild-type and the octamer motif mutanted CCND1 promoters were cloned , and their corresponding luciferase reporter vectors were then constructed to study the molecular mechanism by which *regulates* the expression of [CCND1] and influences the biological behaviors of esophageal cancer cells . Regulation CCND1 PPARA 16917105 1632845 Using small interfering RNA to decrease endogenous PPARalpha expression , it was determined that was partially *involved* in the [cyclin D1] repression . Regulation CCND1 PPARG 15653552 1381567 We obtain evidence that the ability of high doses of troglitazone and ciglitazone to repress [cyclin D1] is *independent* of activation . Regulation CCND1 PPARG 15713663 1395877 In this study , we determined the molecular mechanism by which [cyclin D1] *regulated* function . Regulation CCND1 PRDX2 15585645 1345667 silencing SKP2 gene expression by RNA interference stabilized cyclin D1 and abrogated the [cyclin D1] down-regulation *response* to . Regulation CCND1 PRDX2 16503970 1529138 Additional studies were initiated in order to further investigate the *effect* of on [cyclin D1] regulation using sub-cellular fractionation techniques . Regulation CCND1 PRDX2 24280698 2714875 Assessment of glycogen synthase 3-dependent phosphorylation , subcellular localization and transcription of cyclin D1 indicates that differential *effects* of butyrate and on [cyclin D1] levels are linked to disparity in cyclin D1 gene expression . Regulation CCND1 PRH2 10523665 653572 Finally , we have observed that Dbl and *regulated* transcription from the [cyclin D1] promoter in a NF-kappaB dependent manner . Regulation CCND1 PRKACB 11073968 748834 Further , we show that culture of MCF-7 cells on a cellular substratum of murine preadipocytes also enhanced the functional interaction between [cyclin D1] and ER in a *dependent* manner . Regulation CCND1 PRKACG 11073968 748835 Further , we show that culture of MCF-7 cells on a cellular substratum of murine preadipocytes also enhanced the functional interaction between [cyclin D1] and ER in a *dependent* manner . Regulation CCND1 PRKAR1A 11073968 748836 Further , we show that culture of MCF-7 cells on a cellular substratum of murine preadipocytes also enhanced the functional interaction between [cyclin D1] and ER in a *dependent* manner . Regulation CCND1 PRKAR1B 11073968 748837 Further , we show that culture of MCF-7 cells on a cellular substratum of murine preadipocytes also enhanced the functional interaction between [cyclin D1] and ER in a *dependent* manner . Regulation CCND1 PRKAR2A 11073968 748838 Further , we show that culture of MCF-7 cells on a cellular substratum of murine preadipocytes also enhanced the functional interaction between [cyclin D1] and ER in a *dependent* manner . Regulation CCND1 PRKAR2B 11073968 748839 Further , we show that culture of MCF-7 cells on a cellular substratum of murine preadipocytes also enhanced the functional interaction between [cyclin D1] and ER in a *dependent* manner . Regulation CCND1 PRKCA 12794082 1134016 Deletion of the AP-1 enhancer element located at position -954 upstream from the initiation site abolished *dependent* activation of [cyclin D1] expression . Regulation CCND1 PRKCA 22166648 2366567 Cigarette smoke extract promotes human pulmonary artery smooth muscle cells proliferation through *dependent* induction of [cyclin D1] . Regulation CCND1 PRKCD 12151312 971246 *Regulation* of airway smooth muscle [cyclin D1] transcription by . Regulation CCND1 PRL 11356126 815589 In order to examine the mechanisms by which prolactin may exert trophic effects on its target tissues during development , we have examined the signalling pathways through which binding to the long receptor *regulates* the transcription of [cyclin D1] . Regulation CCND1 PRL 15885880 1426564 This suggests a role for Oct-1 in *dependent* control of [cyclin D1] transcription . Regulation CCND1 PRL 21719533 2471265 PAK1-Nck regulates [cyclin D1] promoter activity in *response* to . Regulation CCND1 PRL 21719533 2471267 [Cyclin D1] expression is directly *regulated* by through the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 5-mediated transcriptional activation of the cyclin D1 promoter . Regulation CCND1 PRL 21719533 2471284 We have previously demonstrated that JAK2 directly phosphorylates PAK1 and extend these data here to demonstrate that PAK1 activates the [cyclin D1] promoter in *response* to . Regulation CCND1 PRL 21719533 2471288 We show that mutation of PAK1 Tyr 153 , 201 , and 285 ( sites of JAK2 phosphorylation ; PAK1 Y3F ) decreases both PAK1 nuclear translocation in *response* to and PRL induced [cyclin D1] promoter activity by 55 % . Regulation CCND1 PRL 21719533 2471304 We propose two PAK1 dependent mechanisms to activate [cyclin D1] promoter activity in *response* to : via nuclear translocation of tyrosyl phosphorylated PAK1 and via formation of a Nck-PAK1 complex that sequesters PAK1 in the cytoplasm . Regulation CCND1 PRSS8 19670249 2150669 *regulates* iNOS and [cyclin D1] expression by modulating protease activated receptor-2 signaling in prostate epithelial cells . Regulation CCND1 PTEN 12917336 1130534 Constitutively active Akt/PKB kinase counteracted the *effect* of on [cyclin D1] translocation . Regulation CCND1 PTEN 17438373 1729260 Here , we show that negatively *regulates* expression of [cyclin D1] and that cyclin D1 plays a unique role in p27 proteolysis . Regulation CCND1 PTGS2 20737317 2313459 [ *Effect* of inhibitor on the expression of BCL-3 and [cyclin D1] in human colon cancer cell line SW480 ] . Regulation CCND1 PTGS2 9101092 423001 Taken together , the results demonstrate that TGF-beta 1 strongly induces COX-2 at both the mRNA and protein levels and suggest that this induction of is *involved* in the down-regulation of [cyclin D1] and inhibition of cell growth caused by TGF-beta 1 in rat intestinal epithelial cells . Regulation CCND1 PTPN11 11502738 868216 Taken together , these findings demonstrate that Ang II-induced [cyclin D1] up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a p21(ras)/Raf-1/MEK/ERK dependent manner , and also *involves* PI3K and . Regulation CCND1 RAC1 10464245 640339 Integration of dependent *regulation* of [cyclin D1] transcription through a nuclear factor-kappaB dependent pathway . Regulation CCND1 RAC1 11017907 737624 We next examined whether PI 3-kinase and the 21-kD guanidine triphosphatase *regulate* [cyclin D(1)] promoter activity by similar mechanisms . Regulation CCND1 RAC1 12919678 1130876 Instead , specific mutation of its nuclear localization and export sequences showed that LIM kinase acts in the nucleus to suppress *dependent* [cyclin D1] expression . Regulation CCND1 RAC1 15377999 1323929 Furthermore , we show that [Cyclin D1] , an important biological Wnt target gene , is *regulated* by in a beta-catenin/TCF dependent manner . Regulation CCND1 RAC1 15652748 1364324 Mechanistically , the effects of Vav1 require its GEF activity and the activation of , PAK1 , and NF-kappaB and *involve* [cyclin D1] upregulation . Regulation CCND1 RAC1 17941827 1849413 Heregulin beta1 promotes breast cancer cell proliferation through *dependent* induction of [cyclin D1] and p21Cip1 . Regulation CCND1 RAC1 18187454 1856831 *dependent* [cyclin D1] gene expression regulated by cadherin- and integrin mediated adhesion . Regulation CCND1 RAC1 19765988 2140735 In contrast , FAK dependent Rac activation , *dependent* [cyclin D1] gene induction , and cyclin D1-dependent Rb phosphorylation are strongly inhibited at physiological tissue stiffness and rescued when the matrix is stiffened in vitro . Regulation CCND1 RAC2 10464245 640340 Integration of *dependent* regulation of [cyclin D1] transcription through a nuclear factor-kappaB dependent pathway . Regulation CCND1 RAC2 12919678 1130877 Instead , specific mutation of its nuclear localization and export sequences showed that LIM kinase acts in the nucleus to suppress *dependent* [cyclin D1] expression . Regulation CCND1 RAC2 17941827 1849414 Heregulin beta1 promotes breast cancer cell proliferation through *dependent* induction of [cyclin D1] and p21Cip1 . Regulation CCND1 RAC2 18187454 1856832 *dependent* [cyclin D1] gene expression regulated by cadherin- and integrin mediated adhesion . Regulation CCND1 RAC2 19765988 2140736 In contrast , FAK dependent Rac activation , *dependent* [cyclin D1] gene induction , and cyclin D1-dependent Rb phosphorylation are strongly inhibited at physiological tissue stiffness and rescued when the matrix is stiffened in vitro . Regulation CCND1 RAC3 10464245 640341 Integration of dependent *regulation* of [cyclin D1] transcription through a nuclear factor-kappaB dependent pathway . Regulation CCND1 RAC3 12919678 1130878 Instead , specific mutation of its nuclear localization and export sequences showed that LIM kinase acts in the nucleus to suppress *dependent* [cyclin D1] expression . Regulation CCND1 RAC3 17941827 1849415 Heregulin beta1 promotes breast cancer cell proliferation through *dependent* induction of [cyclin D1] and p21Cip1 . Regulation CCND1 RAC3 18187454 1856833 *dependent* [cyclin D1] gene expression regulated by cadherin- and integrin mediated adhesion . Regulation CCND1 RAC3 19765988 2140737 In contrast , FAK dependent Rac activation , *dependent* [cyclin D1] gene induction , and cyclin D1-dependent Rb phosphorylation are strongly inhibited at physiological tissue stiffness and rescued when the matrix is stiffened in vitro . Regulation CCND1 RAF1 11502738 868217 Taken together , these findings demonstrate that Ang II-induced [cyclin D1] up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a *dependent* manner , and also involves PI3K and SHP-2 . Regulation CCND1 RALA 11027278 738773 The *regulation* of [cyclin D1] transcription by is dependent on NF-kappaB activation and is mediated through an NF-kappaB binding site in the cyclin D1 promoter . Regulation CCND1 RALA 11027278 738782 Ral activation of these responses is likely through an as yet uncharacterized effector pathway , as we find activation of NF-kappaB and the [cyclin D1] promoter by Ral is *independent* of association of with active phospholipase D1 or Ral binding protein 1 , two proteins proposed to mediate Ral function in cells . Regulation CCND1 RANBP9 24312406 2877946 Functional Interactions between BM88/Cend1 , and Dyrk1B kinase *affect* [cyclin D1] levels and cell cycle progression/exit in mouse neuroblastoma cells . Regulation CCND1 RB1 8175885 255744 Extending the current view of the emerging functional interplay between pRB and D-type cyclins , we now report that [cyclin D1] expression is positively *regulated* by . Regulation CCND1 RB1 8552398 347205 Cyclin D1 can bind and phosphorylate the product ( pRb ) of the retinoblastoma gene ( RB-1 ) and recent evidence suggests , in turn , may *regulate* [cyclin D1] protein expression . Regulation CCND1 RB1 8552398 347209 We show here that does not *regulate* [cyclin D1] directly as basal and serum stimulated levels of cyclin D1 protein and kinase activity are similar in wildtype and pRb-deficient primary mouse embryonic fibroblasts ( MEFs ) . Regulation CCND1 RB1 8623927 354861 [Cyclin D1] mRNA levels were *independent* of expression and the proliferative activity of the tumors . Regulation CCND1 RBBP4 12138206 969213 In addition , INI1/hSNF5 repressed transcription of [cyclin D1] gene in MON , in a *dependent* manner . Regulation CCND1 RBBP7 12138206 969214 In addition , INI1/hSNF5 repressed transcription of [cyclin D1] gene in MON , in a *dependent* manner . Regulation CCND1 RBBP8 16581787 1543865 Similar positive *regulation* of [cyclin D1] expression by was also observed . Regulation CCND1 RBX1 21300445 2398487 *Role* of protein in the control of [cyclin D1] protein expression in skin melanomas . Regulation CCND1 RELA 10409765 630558 *regulation* of [cyclin D1] occurs at the transcriptional level and is mediated by direct binding of NF-kappaB to multiple sites in the cyclin D1 promoter . Regulation CCND1 RELA 10523665 653573 Finally , we have observed that Dbl and Dbs regulated transcription from the [cyclin D1] promoter in a *dependent* manner . Regulation CCND1 RELA 15489214 1321285 The biological effect of Ganoderma lucidum was demonstrated by cell cycle arrest at G0/G1 , which was the result of the downregulation of expression of *regulated* [cyclin D1] , followed by the inhibition of cdk4 . Regulation CCND1 RELA 15652748 1364325 Mechanistically , the effects of Vav1 require its GEF activity and the activation of Rac1 , PAK1 , and and *involve* [cyclin D1] upregulation . Regulation CCND1 RELA 15811958 1425067 The *regulated* gene products [cyclin D1] , cyclooxygenase-2 (COX-2) , matrix metalloproteinase-9 (MMP-9) , survivin , inhibitor-of-apoptosis protein-1 (IAP1) , IAP2 , X chromosome linked IAP (XIAP) , Bcl-2 , Bfl-1/A1 , TNF receptor associated factor-1 (TRAF1) , and Fas associated death domain protein-like interleukin-1beta converting enzyme inhibitory protein ( FLIP ) were all down-regulated by indole-3-carbinol . Regulation CCND1 RELA 16759223 1631484 AP1 and cAMP response element ( CRE ) , but not , were *involved* in the induced [cyclin D1] expression . Regulation CCND1 RELA 17404108 1721549 Vitamin K2 also suppressed the binding site *dependent* [cyclin D1] promoter activity and suppressed the basal , 12-O-tetradecanoylphorbol-13-acetate ( TPA ) - , TNF-alpha- , and interleukin (IL)-1 induced activation of NF-kappaB binding and transactivation . Regulation CCND1 RELA 17440100 1729504 P = 0.036 versus gemcitabine alone ) , Ki-67 proliferation index ( P = 0.030 versus control ) , NF-kappaB activation , and expression of *regulated* gene products ( [cyclin D1] , c-myc , Bcl-2 , Bcl-xL , cellular inhibitor of apoptosis protein-1 , cyclooxygenase-2 , matrix metalloproteinase , and vascular endothelial growth factor ) compared with tumors from control mice treated with olive oil only . Regulation CCND1 RELA 17522064 1778355 The suppression of NF-kappaB activity correlated with inhibition of NF-kappaB reporter activity and with down-regulation of cyclooxygenase-2 , [cyclin D1] and vascular endothelial growth factor , all *regulated* by . Regulation CCND1 RELA 19623659 2131232 This effect was accompanied by suppressed expression of activated NF-kappaB and *regulated* gene products ( [cyclin D1] , c-myc , bcl-2 , bcl-xL , cIAP-1 , COX-2 , ICAM-1 , MMP-9 , CXCR4 and VEGF ) . Regulation CCND1 REM2 20231315 2223775 We show that the *effects* of on [cyclin D(1)] are independent of p53 function . Regulation CCND1 RHO 10611246 656162 Induction of [cyclin D1] by NeuT *involved* Ras , Rac , , extracellular signal regulated kinase , c-Jun N-terminal kinase , and p38 , but not phosphatidylinositol 3-kinase . Regulation CCND1 RHO 11896588 922799 *regulates* p21 ( CIP1 ) , [cyclin D1] , and checkpoint control in mammary epithelial cells . Regulation CCND1 RHO 12919678 1130865 Nuclear translocation of LIM kinase mediates kinase *regulation* of [cyclin D1] expression . Regulation CCND1 RHO 19730435 2139509 Our data thus indicate that GEF-H1 and ZONAB form a signalling module that mediates *regulated* [cyclin D1] promoter activation and expression . Regulation CCND1 RHOA 16776827 1585545 To further explore *regulation* of [cyclin D1] in lung fibroblasts and associated cell cycle progression , an established Rho inhibitor , Simvastatin , was incorporated in our studies . Regulation CCND1 RHOA 18045963 1832928 Vasopressin triggers senescence in K-ras transformed cells via *dependent* downregulation of [cyclin D1] . Regulation CCND1 RICTOR 24626091 2934222 Notably , selective inhibition of mTORC2 triggered proteasome mediated cyclin D1 degradation , suggesting that blockade is *responsible* for GSK3 dependent reduction of [cyclin D1] . Regulation CCND1 RPAP1 22264791 2545032 CREPT *regulates* [cyclin D1] expression by binding to its promoter , enhancing its transcription both in vivo and in vitro , and interacting with . Regulation CCND1 RPTOR 19225536 2054552 As is activated in MCL and may *control* [cyclin D1] levels , we show that p53 activation may downregulate the AKT/mTOR pathway through a mechanism involving AMP kinase (AMPK) . Regulation CCND1 S100A8 16759223 1631480 We explored the *effect* of H. pylori on expression of [cyclin D1] , an important cell cycle regulator . Regulation CCND1 SASH1 23108792 2717370 Furthermore , the *effect* of on the expression of [cyclin D1] , caspase-3 , matrix metalloproteinase (MMP)-9 were observed by western blot . Regulation CCND1 SETD2 20179204 2215909 Overexpression of the dominant negative mutant of HIF-1alpha ( DN-HIF ) significantly enhanced cyclin D1 expression upon hypoxia or arsenite exposure , suggesting the negative *regulation* of [cyclin D1] by . Regulation CCND1 SETD2 20179204 2215911 Chromatin immunoprecipitation assay revealed that HIF-1 was able to directly bind to the promoter region of cyclin D1 , which indicates that the negative *regulation* of [cyclin D1] by is through a direct mechanism . Regulation CCND1 SETD2 23455892 2713959 [CCND1] ( cyclin D1 ) expression could be *regulated* by PPAR? and via the cell cycle pathway . Regulation CCND1 SFN 16170570 1500434 Furthermore , the activation of the ERK and p38 pathways by is *involved* in the upregulation of p21 ( CIP1 ) and [cyclin D1] , whereas the activation of the JNK pathway plays a contradictory role and may be partially involved in the downregulation of cyclin D1 . Regulation CCND1 SGTA 22752428 2659728 an enzymatically inactive did not *affect* [cyclin D1] stability . Regulation CCND1 SHH 15277480 1277208 *Effects* of exogenous on cell proliferation and [cyclin D1] expression were determined in healing corneal epithelium of organ cultured mouse eyes . Regulation CCND1 SIX1 23636126 2810567 The AP-1 mutation did not affect *dependent* activation of [cyclin D1] . Regulation CCND1 SIX1 24114014 2926457 In addition , we investigated the *effects* of on the expression of following proteins ( [cyclin D1] , caspase-3 , and vascular endothelial growth factor-C ( VEGF-C ) ) . Regulation CCND1 SKP2 15585645 1345665 [Cyclin D1] degradation *involved* , a regulatory component of the Skp1/Cullin/F-box complex ; Regulation CCND1 SKP2 16924241 1692251 Additionally , B-RAF and [cyclin D1] *control* the levels of ( Skp2 ) that directs ubiquitin mediated proteolysis of p27 ( Kip1 ) . Regulation CCND1 SLC2A4RG 15652748 1364321 Mechanistically , the effects of Vav1 require its activity and the activation of Rac1 , PAK1 , and NF-kappaB and *involve* [cyclin D1] upregulation . Regulation CCND1 SLFN11 18373498 1925448 In addition , DnaJB6 increased 's *effect* on its downstream target [cyclin D1] in co-transfected cells . Regulation CCND1 SLFN12 18373498 1925446 In addition , DnaJB6 increased 's *effect* on its downstream target [cyclin D1] in co-transfected cells . Regulation CCND1 SLFN13 18373498 1925447 In addition , DnaJB6 increased 's *effect* on its downstream target [cyclin D1] in co-transfected cells . Regulation CCND1 SLFN14 18373498 1925450 In addition , DnaJB6 increased 's *effect* on its downstream target [cyclin D1] in co-transfected cells . Regulation CCND1 SLFN5 18373498 1925449 In addition , DnaJB6 increased 's *effect* on its downstream target [cyclin D1] in co-transfected cells . Regulation CCND1 SMAD2 16871886 1593206 Overall , the expression of the and Smad3 proteins was low in the glioma cell lines , the phosphorylation and nuclear translocation of Smad2 and Smad3 were impaired , and the TGFbeta receptor signal did not *affect* the expression of the SnoN , p21 , p15 , [cyclin D1] , and CDK4 proteins . Regulation CCND1 SMAD3 16871886 1593207 Overall , the expression of the Smad2 and proteins was low in the glioma cell lines , the phosphorylation and nuclear translocation of Smad2 and Smad3 were impaired , and the TGFbeta receptor signal did not *affect* the expression of the SnoN , p21 , p15 , [cyclin D1] , and CDK4 proteins . Regulation CCND1 SNAI2 22801439 2628656 *regulates* [Cyclin D1] expression by ubiquitin-proteasome pathway in prostate cancer cells . Regulation CCND1 SNAI2 22801439 2628658 And *regulates* [cyclin D1] expression by ubiquitin-proteasome pathway in PCa cells . Regulation CCND1 SNIP1 17260016 1765565 Moreover , we have demonstrated previously that *regulates* [cyclin D1] expression and promoter activity . Regulation CCND1 SNIP1 18794151 1964348 Rather , *plays* a critical role in cotranscriptional or posttranscriptional [Cyclin D1] mRNA stability . Regulation CCND1 SPAG9 24740566 2943395 In addition , we found that could *regulate* [cyclin D1] and cyclin E protein expression . Regulation CCND1 SPP1 19926637 2198011 Moreover , transfection of cells with wt STAT3 upregulates whereas STAT3 Y705F downregulates Bcl2 and [cyclin D1] expressions in *response* to . Regulation CCND1 SRC 12907754 1157471 Moreover , we show that both and c-Src/Fak/Erk1/2 pathways are *involved* in the up-regulation of c-myc and [cyclin d1] expression mediated by PRL . Regulation CCND1 SSX2 12097301 961291 However , *regulated* [cyclin D1] expression was proven to be independent of the glycogen synthetase kinase-3beta pathway . Regulation CCND1 SSX2 12097301 961297 *dependent* expression of [cyclin D1] may be an important mechanism in the development and progression of synovial sarcoma and also raises the possibility for targeted therapy . Regulation CCND1 STAT3 12067972 955147 In view of the fact that signal transducers and activators of transcription 3 ( Stat3 ) is often activated in HNSCC cells , we examined the *effects* of on [cyclin D1] expression and cell proliferation in the YCU-H891 HNSCC cell line that displays constitutive activation of Stat3 . Regulation CCND1 STAT3 12067972 955148 This study provides the first evidence that in HNSCC , constitutive activation of *plays* a causative role in overexpression of [cyclin D1] , and in clinical studies , Stat3 activation may provide a novel prognostic factor . Regulation CCND1 STAT3 12707028 1082773 The study aim was to investigate activation in a series of multiple myeloma ( MM ) cases and its *effect* on downstream targets such as the anti-apoptotic proteins Bcl-xL , Mcl-1 , and Bcl-2 , and the cell-cycle protein [cyclin D1] . Regulation CCND1 STAT3 17322172 1719825 IL-6 also induced [cyclin D1] expression in a time- and *dependent* manner in VSMCs . Regulation CCND1 STAT3 17344214 1726957 Our data suggest that [CYCLIN D1] may be a target gene for leptin mediated growth stimulation of breast cancer cells and molecular mechanisms *involve* activated mediated recruitment of distinct coactivator complexes . Regulation CCND1 STAT3 21163886 2396288 These results indicate that *plays* an important role in BITC mediated inhibition of leptin induced [cyclin D1] transactivation . Regulation CCND1 STAT5A 10064602 593444 Transcriptional *regulation* of the [cyclin D1] promoter by : its involvement in cytokine dependent growth of hematopoietic cells . Regulation CCND1 STAT5A 16172916 1457395 Here , the binding of might up *regulate* [cyclin D1] in most of the samples whereas ; Regulation CCND1 STAT5A 18316550 1880921 The *effects* of on the viability of prostate cancer cells involve Stat5a/b regulation of Bcl-X ( L ) and [cyclin D1] protein levels but not the expression or activation of Stat3 . Regulation CCND1 STAT5A 19426693 2076714 *Involvement* of signaling in morphine induced up-regulation of the [cyclin D1] . Regulation CCND1 STAT5A 21079973 2371618 Our findings provide the first evidence that may *play* an important role in [cyclin D1] overexpression and contribute to colonic adenocarcinoma progression . Regulation CCND1 STAT5A 23504816 2772042 Overexpression studies confirmed increase in [cyclin D1] expression in *response* to and STAT5b constructs when compared to dominant negative STAT5 . Regulation CCND1 STAT5A 23504816 2772044 siRNA targeting STAT5 , diminished the cyclin D1 expression , further confirming that specifically *regulated* [cyclin D1] in neuronal cells . Regulation CCND1 STC2 23187001 2704711 Western blot analysis demonstrated that could *regulate* the expression of [cyclin D1] and activate extracellular signal regulated kinase 1/2 ( ERK1/2 ) in a dominant positive manner . Regulation CCND1 STK10 21719533 2471268 A p21 activated ( PAK)1 has also been implicated in the *regulation* of [cyclin D1] gene expression . Regulation CCND1 STK11 21719533 2471269 A p21 activated ( PAK)1 has also been implicated in the *regulation* of [cyclin D1] gene expression . Regulation CCND1 STK16 21719533 2471270 A p21 activated ( PAK)1 has also been implicated in the *regulation* of [cyclin D1] gene expression . Regulation CCND1 STK19 21719533 2471271 A p21 activated ( PAK)1 has also been implicated in the *regulation* of [cyclin D1] gene expression . Regulation CCND1 STK24 21719533 2471272 A p21 activated ( PAK)1 has also been implicated in the *regulation* of [cyclin D1] gene expression . Regulation CCND1 STK25 21719533 2471273 A p21 activated ( PAK)1 has also been implicated in the *regulation* of [cyclin D1] gene expression . Regulation CCND1 STK3 21719533 2471274 A p21 activated ( PAK)1 has also been implicated in the *regulation* of [cyclin D1] gene expression . Regulation CCND1 STK31 21719533 2471275 A p21 activated ( PAK)1 has also been implicated in the *regulation* of [cyclin D1] gene expression . Regulation CCND1 STK33 21719533 2471277 A p21 activated ( PAK)1 has also been implicated in the *regulation* of [cyclin D1] gene expression . Regulation CCND1 STK35 21719533 2471278 A p21 activated ( PAK)1 has also been implicated in the *regulation* of [cyclin D1] gene expression . Regulation CCND1 STK36 21719533 2471279 A p21 activated ( PAK)1 has also been implicated in the *regulation* of [cyclin D1] gene expression . Regulation CCND1 STK38 21719533 2471281 A p21 activated ( PAK)1 has also been implicated in the *regulation* of [cyclin D1] gene expression . Regulation CCND1 STK39 21719533 2471280 A p21 activated ( PAK)1 has also been implicated in the *regulation* of [cyclin D1] gene expression . Regulation CCND1 STK4 21719533 2471276 A p21 activated ( PAK)1 has also been implicated in the *regulation* of [cyclin D1] gene expression . Regulation CCND1 STK40 21719533 2471282 A p21 activated ( PAK)1 has also been implicated in the *regulation* of [cyclin D1] gene expression . Regulation CCND1 SYT1 12097301 961292 However , *regulated* [cyclin D1] expression was proven to be independent of the glycogen synthetase kinase-3beta pathway . Regulation CCND1 SYT1 12097301 961298 *dependent* expression of [cyclin D1] may be an important mechanism in the development and progression of synovial sarcoma and also raises the possibility for targeted therapy . Regulation CCND1 TAB1 10048449 592532 Western blot analysis demonstrates that the level of [cyclin D1] protein was *regulated* negatively by overexpression of . Regulation CCND1 TAB2 21911473 2496825 Collectively , these data reveal a requisite *role* for the SCF ( Fbx4 ) E3 in regulating [cyclin D1] accumulation , consistent with tumor suppressive function in vivo . Regulation CCND1 TAF1 9926939 588386 Taken together , the results suggest that [cyclin D1] may *regulate* transcription by interacting directly or indirectly with . Regulation CCND1 TCF12 15126340 1244821 Because [cyclin D1] is mainly *regulated* by , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Regulation CCND1 TCF12 15377999 1323917 Furthermore , we show that [Cyclin D1] , an important biological Wnt target gene , is regulated by Rac1 in a *dependent* manner . Regulation CCND1 TCF12 16508013 1530247 *Regulation* of PCNA and [cyclin D1] expression and epithelial morphogenesis by the ZO-1 regulated ZONAB/DbpA . Regulation CCND1 TCF12 21505178 2458349 Furthermore , a promoter analysis revealed that the activator protein-1 *regulates* EGF induced [cyclin D1] overexpression . Regulation CCND1 TCF12 22005519 2526399 *dependent* transcriptional activity and [cyclin D1] promoter activity were revealed to be inhibited via suppression of transcription factor 7-like 2 (TCF7L2) expression . Regulation CCND1 TCF12 24801166 2937438 Expression of [cyclin-D1] , a key inducer of transition from the G1 to S phase of cell cycle , is *regulated* by <ß-catenin-TCF> complex . Regulation CCND1 TCF15 15126340 1244822 Because [cyclin D1] is mainly *regulated* by , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Regulation CCND1 TCF15 15377999 1323918 Furthermore , we show that [Cyclin D1] , an important biological Wnt target gene , is regulated by Rac1 in a *dependent* manner . Regulation CCND1 TCF15 16508013 1530248 *Regulation* of PCNA and [cyclin D1] expression and epithelial morphogenesis by the ZO-1 regulated ZONAB/DbpA . Regulation CCND1 TCF15 21505178 2458350 Furthermore , a promoter analysis revealed that the activator protein-1 *regulates* EGF induced [cyclin D1] overexpression . Regulation CCND1 TCF15 22005519 2526400 *dependent* transcriptional activity and [cyclin D1] promoter activity were revealed to be inhibited via suppression of transcription factor 7-like 2 (TCF7L2) expression . Regulation CCND1 TCF15 24801166 2937439 Expression of [cyclin-D1] , a key inducer of transition from the G1 to S phase of cell cycle , is *regulated* by <ß-catenin-TCF> complex . Regulation CCND1 TCF19 15126340 1244823 Because [cyclin D1] is mainly *regulated* by , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Regulation CCND1 TCF19 15377999 1323919 Furthermore , we show that [Cyclin D1] , an important biological Wnt target gene , is regulated by Rac1 in a *dependent* manner . Regulation CCND1 TCF19 16508013 1530249 *Regulation* of PCNA and [cyclin D1] expression and epithelial morphogenesis by the ZO-1 regulated ZONAB/DbpA . Regulation CCND1 TCF19 21505178 2458351 Furthermore , a promoter analysis revealed that the activator protein-1 *regulates* EGF induced [cyclin D1] overexpression . Regulation CCND1 TCF19 22005519 2526401 *dependent* transcriptional activity and [cyclin D1] promoter activity were revealed to be inhibited via suppression of transcription factor 7-like 2 (TCF7L2) expression . Regulation CCND1 TCF19 24801166 2937440 Expression of [cyclin-D1] , a key inducer of transition from the G1 to S phase of cell cycle , is *regulated* by <ß-catenin-TCF> complex . Regulation CCND1 TCF20 15126340 1244824 Because [cyclin D1] is mainly *regulated* by , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Regulation CCND1 TCF20 15377999 1323920 Furthermore , we show that [Cyclin D1] , an important biological Wnt target gene , is regulated by Rac1 in a *dependent* manner . Regulation CCND1 TCF20 16508013 1530250 *Regulation* of PCNA and [cyclin D1] expression and epithelial morphogenesis by the ZO-1 regulated ZONAB/DbpA . Regulation CCND1 TCF20 21505178 2458352 Furthermore , a promoter analysis revealed that the activator protein-1 *regulates* EGF induced [cyclin D1] overexpression . Regulation CCND1 TCF20 22005519 2526402 *dependent* transcriptional activity and [cyclin D1] promoter activity were revealed to be inhibited via suppression of transcription factor 7-like 2 (TCF7L2) expression . Regulation CCND1 TCF20 24801166 2937441 Expression of [cyclin-D1] , a key inducer of transition from the G1 to S phase of cell cycle , is *regulated* by <ß-catenin-TCF> complex . Regulation CCND1 TCF21 15126340 1244825 Because [cyclin D1] is mainly *regulated* by , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Regulation CCND1 TCF21 15377999 1323921 Furthermore , we show that [Cyclin D1] , an important biological Wnt target gene , is regulated by Rac1 in a *dependent* manner . Regulation CCND1 TCF21 16508013 1530251 *Regulation* of PCNA and [cyclin D1] expression and epithelial morphogenesis by the ZO-1 regulated ZONAB/DbpA . Regulation CCND1 TCF21 21505178 2458353 Furthermore , a promoter analysis revealed that the activator protein-1 *regulates* EGF induced [cyclin D1] overexpression . Regulation CCND1 TCF21 22005519 2526403 *dependent* transcriptional activity and [cyclin D1] promoter activity were revealed to be inhibited via suppression of transcription factor 7-like 2 (TCF7L2) expression . Regulation CCND1 TCF21 24801166 2937442 Expression of [cyclin-D1] , a key inducer of transition from the G1 to S phase of cell cycle , is *regulated* by <ß-catenin-TCF> complex . Regulation CCND1 TCF23 15126340 1244829 Because [cyclin D1] is mainly *regulated* by , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Regulation CCND1 TCF23 15377999 1323925 Furthermore , we show that [Cyclin D1] , an important biological Wnt target gene , is regulated by Rac1 in a *dependent* manner . Regulation CCND1 TCF23 16508013 1530255 *Regulation* of PCNA and [cyclin D1] expression and epithelial morphogenesis by the ZO-1 regulated ZONAB/DbpA . Regulation CCND1 TCF23 21505178 2458357 Furthermore , a promoter analysis revealed that the activator protein-1 *regulates* EGF induced [cyclin D1] overexpression . Regulation CCND1 TCF23 22005519 2526407 *dependent* transcriptional activity and [cyclin D1] promoter activity were revealed to be inhibited via suppression of transcription factor 7-like 2 (TCF7L2) expression . Regulation CCND1 TCF23 24801166 2937446 Expression of [cyclin-D1] , a key inducer of transition from the G1 to S phase of cell cycle , is *regulated* by <ß-catenin-TCF> complex . Regulation CCND1 TCF24 15126340 1244832 Because [cyclin D1] is mainly *regulated* by , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Regulation CCND1 TCF24 15377999 1323928 Furthermore , we show that [Cyclin D1] , an important biological Wnt target gene , is regulated by Rac1 in a *dependent* manner . Regulation CCND1 TCF24 16508013 1530257 *Regulation* of PCNA and [cyclin D1] expression and epithelial morphogenesis by the ZO-1 regulated ZONAB/DbpA . Regulation CCND1 TCF24 21505178 2458359 Furthermore , a promoter analysis revealed that the activator protein-1 *regulates* EGF induced [cyclin D1] overexpression . Regulation CCND1 TCF24 22005519 2526409 *dependent* transcriptional activity and [cyclin D1] promoter activity were revealed to be inhibited via suppression of transcription factor 7-like 2 (TCF7L2) expression . Regulation CCND1 TCF24 24801166 2937448 Expression of [cyclin-D1] , a key inducer of transition from the G1 to S phase of cell cycle , is *regulated* by <ß-catenin-TCF> complex . Regulation CCND1 TCF25 15126340 1244831 Because [cyclin D1] is mainly *regulated* by , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Regulation CCND1 TCF25 15377999 1323927 Furthermore , we show that [Cyclin D1] , an important biological Wnt target gene , is regulated by Rac1 in a *dependent* manner . Regulation CCND1 TCF25 16508013 1530256 *Regulation* of PCNA and [cyclin D1] expression and epithelial morphogenesis by the ZO-1 regulated ZONAB/DbpA . Regulation CCND1 TCF25 21505178 2458358 Furthermore , a promoter analysis revealed that the activator protein-1 *regulates* EGF induced [cyclin D1] overexpression . Regulation CCND1 TCF25 22005519 2526408 *dependent* transcriptional activity and [cyclin D1] promoter activity were revealed to be inhibited via suppression of transcription factor 7-like 2 (TCF7L2) expression . Regulation CCND1 TCF25 24801166 2937447 Expression of [cyclin-D1] , a key inducer of transition from the G1 to S phase of cell cycle , is *regulated* by <ß-catenin-TCF> complex . Regulation CCND1 TCF3 15126340 1244826 Because [cyclin D1] is mainly *regulated* by , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Regulation CCND1 TCF3 15377999 1323922 Furthermore , we show that [Cyclin D1] , an important biological Wnt target gene , is regulated by Rac1 in a *dependent* manner . Regulation CCND1 TCF3 16508013 1530252 *Regulation* of PCNA and [cyclin D1] expression and epithelial morphogenesis by the ZO-1 regulated ZONAB/DbpA . Regulation CCND1 TCF3 21505178 2458354 Furthermore , a promoter analysis revealed that the activator protein-1 *regulates* EGF induced [cyclin D1] overexpression . Regulation CCND1 TCF3 22005519 2526404 *dependent* transcriptional activity and [cyclin D1] promoter activity were revealed to be inhibited via suppression of transcription factor 7-like 2 (TCF7L2) expression . Regulation CCND1 TCF3 24801166 2937443 Expression of [cyclin-D1] , a key inducer of transition from the G1 to S phase of cell cycle , is *regulated* by <ß-catenin-TCF> complex . Regulation CCND1 TCF4 15126340 1244827 Because [cyclin D1] is mainly *regulated* by , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Regulation CCND1 TCF4 15377999 1323923 Furthermore , we show that [Cyclin D1] , an important biological Wnt target gene , is regulated by Rac1 in a *dependent* manner . Regulation CCND1 TCF4 16508013 1530253 *Regulation* of PCNA and [cyclin D1] expression and epithelial morphogenesis by the ZO-1 regulated ZONAB/DbpA . Regulation CCND1 TCF4 21505178 2458355 Furthermore , a promoter analysis revealed that the activator protein-1 *regulates* EGF induced [cyclin D1] overexpression . Regulation CCND1 TCF4 22005519 2526405 *dependent* transcriptional activity and [cyclin D1] promoter activity were revealed to be inhibited via suppression of transcription factor 7-like 2 (TCF7L2) expression . Regulation CCND1 TCF4 24801166 2937444 Expression of [cyclin-D1] , a key inducer of transition from the G1 to S phase of cell cycle , is *regulated* by <ß-catenin-TCF> complex . Regulation CCND1 TCF7 15126340 1244828 Because [cyclin D1] is mainly *regulated* by , TCF-4 response element was used in a reporter gene transcription assay , demonstrating that HOXB13 significantly inhibits TCF-4 mediated transcriptional activity in both prostate and nonprostate cells . Regulation CCND1 TCF7 15377999 1323924 Furthermore , we show that [Cyclin D1] , an important biological Wnt target gene , is regulated by Rac1 in a *dependent* manner . Regulation CCND1 TCF7 16508013 1530254 *Regulation* of PCNA and [cyclin D1] expression and epithelial morphogenesis by the ZO-1 regulated ZONAB/DbpA . Regulation CCND1 TCF7 21505178 2458356 Furthermore , a promoter analysis revealed that the activator protein-1 *regulates* EGF induced [cyclin D1] overexpression . Regulation CCND1 TCF7 22005519 2526406 *dependent* transcriptional activity and [cyclin D1] promoter activity were revealed to be inhibited via suppression of transcription factor 7-like 2 (TCF7L2) expression . Regulation CCND1 TCF7 24801166 2937445 Expression of [cyclin-D1] , a key inducer of transition from the G1 to S phase of cell cycle , is *regulated* by <ß-catenin-TCF> complex . Regulation CCND1 TCF7L2 10679386 668918 For instance the discovery that [cyclin D1] is *regulated* by allows us to tie the APC pathway to the RB pathway and cell cycle control . Regulation CCND1 TGFA 16939931 1609351 [ *Effect* of on the expression of cyclin E and [cyclin D1] in gastric carcinoma cells ] . Regulation CCND1 TGFB1 10471535 641896 In the present study , we investigated the *effects* of on [cyclin D1] expression and activity in COLO-357 human pancreatic cancer cells . Regulation CCND1 TGFB1 9299547 453766 We investigated the *effects* of on [cyclin D1] , cyclin A , p21 , p27 , and p53 mRNA expressions in primary cultured rat hepatocytes by the reverse-transcription polymerase chain reaction ( RT-PCR ) method . Regulation CCND1 THPO 14645506 1172176 We now show that *dependent* activation of the [cyclin D1] promoter depends on the integrity of a new bipartite proximal element that specifically binds STAT5A and -B transcription factors . Regulation CCND1 TIMP1 16407831 1561058 We also show that mediated differential *regulation* of [cyclin D(1)] and p27 ( KIP1 ) is independent of cell adhesion signaling . Regulation CCND1 TIPRL 25135222 2957397 nuclear translocation negatively *regulates* EGF dependent [cyclin D1] transcription in human lung adenocarcinoma . Regulation CCND1 TIPRL 25135222 2957400 Chromatin immunoprecipitation assays revealed that negatively *regulated* EGF dependent transcriptional activation of [CCND1] through a HDAC1 dependent mechanism . Regulation CCND1 TJP2 17881732 1823722 Here , we have studied the *role* of , a TJ peripheral protein , in the regulation of [cyclin D1] transcription . Regulation CCND1 TJP2 17881732 1823725 To understand how ZO-2 represses cyclin D1 promoter activity , we used deletion analyses and found that negatively *regulates* [cyclin D1] transcription via an E box and that it diminishes cell proliferation . Regulation CCND1 TMED7 11381079 820619 However , recent evidence about the stabilizing *effect* of on [cyclin D1-Cdk4] complexes suggests that p27 deficiency might recapitulate the hypoplastic mammary phenotype of cyclin D1-deficient animals . Regulation CCND1 TMED7 15154924 1250404 Lower levels of [cyclin D1] were detected in the JE of p21/p27 knockout mice , suggesting that p21 and *regulate* stability of cyclin D1 in oral epithelium . Regulation CCND1 TNP1 7980579 281355 The *effects* of on DNA synthesis and the expression of c-myc and [cyclin D1] mRNAs were investigated in human umbilical vein endothelial ( HUVE ) cells synchronized by serum depletion and stimulated with bFGF and serum . Regulation CCND1 TNP2 7980579 281356 The *effects* of on DNA synthesis and the expression of c-myc and [cyclin D1] mRNAs were investigated in human umbilical vein endothelial ( HUVE ) cells synchronized by serum depletion and stimulated with bFGF and serum . Regulation CCND1 TP53 10834541 697785 These findings suggested the hypothesis that prior aberrant expression may affect or *regulate* the overexpression of [cyclin D1] . Regulation CCND1 TP53 12480939 1078966 Bcl-2 controls caspase activation following a *dependent* [cyclin D1-induced] death signal . Regulation CCND1 TP53 17443686 1760945 We found that the decrease in [cyclin D1] levels induced by NO was GSH-sensitive implying that the redox regulation of NO-mediated cytostasis was a multifaceted process and that both and p53 independent cyclin D1 pathways were *involved* . Regulation CCND1 TP53 20214871 2243457 [Cyclin D1] responses were *independent* of and resulted in a partial loss of Retinoblastoma protein phosphorylation . Regulation CCND1 TP53 20231315 2223774 We show that the effects of Rem2 on [cyclin D(1)] are *independent* of function . Regulation CCND1 TP53 7784093 309889 The *role* of in coordinated regulation of [cyclin D1] and p21 gene expression by the adenovirus E1A and E1B oncogenes . Regulation CCND1 TP53 7784093 309893 Since E1B was shown to target p53 , we investigated the *role* of for expression of the [cyclin D1] gene . Regulation CCND1 TRAF6 21911473 2496823 Collectively , these data reveal a requisite *role* for the SCF ( Fbx4 ) E3 in regulating [cyclin D1] accumulation , consistent with tumor suppressive function in vivo . Regulation CCND1 UBE2V1 21911473 2496824 Collectively , these data reveal a requisite *role* for the SCF ( Fbx4 ) E3 in regulating [cyclin D1] accumulation , consistent with tumor suppressive function in vivo . Regulation CCND1 VAV1 15652748 1364320 Mechanistically , the *effects* of require its GEF activity and the activation of Rac1 , PAK1 , and NF-kappaB and involve [cyclin D1] upregulation . Regulation CCND1 VDR 21816960 2500450 Silencing VDR by sh-RNA demonstrated that suppression of [cyclin D1] and collagen Ia1 protein expression was *dependent* . Regulation CCND1 VEGFA 16899623 1601251 Small interfering RNA against cyclin D1 was also used to analyze [cyclin D1] inhibition associated ( VEGF ) *regulation* . Regulation CCND1 VHL 12036906 949163 mediated hypoxia *regulation* of [cyclin D1] in renal carcinoma cells . Regulation CCND1 WHSC1 22028615 2499197 interacts with some proteins related to the WNT pathway including ß-catenin and transcriptionally *regulates* [CCND1] , the target gene of the ß-catenin/Tcf-4 complex , through histone H3 at lysine 36 trimethylation . Regulation CCND1 WNT1 22204713 2612213 In conclusion , we have demonstrated that expression of cyclin D1 is linked to nodal metastases and that [cyclin D1] levels are *regulated* by signaling . Regulation CCND1 WNT11 22204713 2612214 In conclusion , we have demonstrated that expression of cyclin D1 is linked to nodal metastases and that [cyclin D1] levels are *regulated* by signaling . Regulation CCND1 WNT16 22204713 2612219 In conclusion , we have demonstrated that expression of cyclin D1 is linked to nodal metastases and that [cyclin D1] levels are *regulated* by signaling . Regulation CCND1 WNT2 22204713 2612215 In conclusion , we have demonstrated that expression of cyclin D1 is linked to nodal metastases and that [cyclin D1] levels are *regulated* by signaling . Regulation CCND1 WNT3 22204713 2612216 In conclusion , we have demonstrated that expression of cyclin D1 is linked to nodal metastases and that [cyclin D1] levels are *regulated* by signaling . Regulation CCND1 WNT4 22204713 2612217 In conclusion , we have demonstrated that expression of cyclin D1 is linked to nodal metastases and that [cyclin D1] levels are *regulated* by signaling . Regulation CCND1 WNT6 22204713 2612218 In conclusion , we have demonstrated that expression of cyclin D1 is linked to nodal metastases and that [cyclin D1] levels are *regulated* by signaling . Regulation CCND1 XIAP 23720779 2811622 ( XIAP ) *regulation* of [cyclin D1] protein expression and cancer cell anchorage independent growth via its E3 ligase mediated protein phosphatase 2A/c-Jun axis . Regulation CCND1 ZFP36 16702957 1624686 *regulates* [Cyclin D1] and c-Myc mRNA stability in response to rapamycin in an Akt dependent manner via p38 MAPK signaling . Regulation CCND3 IFI27 9120257 423769 These data suggest that IL-4 controls B cell proliferation by action during at least two steps of the regulation of the cell cycle , [cyclin D3/cdk6] complex *regulation* and inhibitor expression . Regulation CCND3 IFI27 9693368 523670 We report that [cyclin D3/cdk4] kinase activity is *regulated* by ( kip1 ) in BALB/c 3T3 cells . Regulation CCND3 MAP2K6 16815849 1606128 [Cyclin D3] expression was enhanced in a cell panel of human melanoma cell lines compared with melanocytes and was *regulated* by fibronectin mediated phosphatidylinositol 3-kinase/Akt signaling but not activity . Regulation CCNG1 CCND1 7666202 322123 These results indicate that NGF induction of and inactivation of cdk kinases , the latter possibly by increase of p21 , *play* a central role in the NGF block of PC12 cell [cycling] . Regulation CCNG1 FOLR1 3021316 64526 As is *involved* in substrate [cycling] , inappropriately high activity reflects an inability to adapt to malnutrition that could lead to high rates of cycling and wasteful energy expenditure at times of maximal activation of the cycle . Regulation CCNG1 MMP28 21454403 2432624 Notably , although EGFR or inhibition minimally *affects* estrous [cycling] in female mice , they attenuate ovarian steroidogenesis in response to LHR overstimulation in vivo . Regulation CCNG1 MMP7 21454403 2432640 Notably , although EGFR or inhibition minimally *affects* estrous [cycling] in female mice , they attenuate ovarian steroidogenesis in response to LHR overstimulation in vivo . Regulation CCNG1 PCSK9 18054775 1861154 These observations suggest an *involvement* of in hepatic LDL receptor protein degradation and perhaps , in increasing the rate of LDL receptor [cycling] resulting in lower serum cholesterol levels in response to cholesterol biosynthesis inhibitors . Regulation CCNG1 RARB 8056839 268035 Using these ` pMARK ' vectors , a fluorescence based , single cell proliferation assay was developed and used to study the *effect* of on cell [cycling] . Regulation CCNG1 TF 2604716 123668 The [cycling] of the transferrin receptor is therefore *regulated* by diferric via an increase in both the rate of endocytosis and exocytosis . Regulation CCNG1 TLR7 19299704 2051882 Reduced c-myc expression levels limit follicular mature B cell [cycling] in *response* to signals . Regulation CCNG1 TMOD1 11855658 893576 Ca2+ sensitizers act on the central mechanism ( Ca2+ binding affinity of troponin C ) and/or downstream mechanisms ( regulation of actin and direct *action* on crossbridge [cycling] ) of cardiac E-C coupling . Regulation CCNG1 TMOD1 16799263 1579260 upstream ( Ca ( 2+ ) mobilization ) , central ( Ca ( 2+ ) binding to troponin C ) , and/or downstream ( *regulation* of troponin C property or crossbridge [cycling] and crossbridge cycling activity itself ) mechanisms . Regulation CCNG1 TNF 21544382 407748 G-CSF abolished the inhibitory *effects* of on the cell [cycling] of hematopoietic progenitors . Regulation CCR2 RGS16 12874248 1115020 These results suggest that may *regulate* T lymphocyte activation in response to inflammatory stimuli and migration induced by CXCR4 , CCR3 , and CCR5 , but not [CCR2] or CCR7 . Regulation CCR4 CCL17 14971049 1209435 The differential CCR4 desensitization and internalization reported here and the distinct expression patterns of CCL17 and CCL22 observed in vivo suggest that while may *act* first on [CCR4] at the endothelial surface to promote vascular recognition , CCL22 could subsequently engage the receptor within the tissue microenvironment to guide cellular localization . Regulation CCR4 CCL17 18403600 1899548 Thus , these results demonstrate that *dependent* activation of [CCR4] in macrophages plays a central role in free radical induced pulmonary injury and repair . Regulation CCR5 SELL 12609846 1085250 Engagement of by antibody cross linking or the L-selectin ligands fucoidan or sulfatide mobilized intracellular CXCR4 to significantly increase surface CXCR4 expression but did not *affect* [CCR5] , CCR7 , or beta2-integrin expression . Regulation CCR5 STAT4 11739505 886528 A mandatory *role* for in IL-12 induction of mouse T cell [CCR5] . Regulation CCR5 STAT4 11739505 886533 Considering that STAT4 is the most critical of IL-12 signaling molecules , this study investigated the *role* for in the induction of [CCR5] expression . Regulation CCR6 TNF 11090084 754443 Neutralization with IgG against several cytokines revealed that was largely *responsible* for the PHA-sup induced [CCR6] mRNA expression . Regulation CCR7 FOXO1 19136962 2025514 In naive T cells , *controlled* the expression of the adhesion molecule L-selectin , the chemokine receptor [CCR7] and the transcription factor Klf2 , and its deletion was sufficient to alter lymphocyte trafficking . Regulation CCR7 RGS16 12874248 1115021 These results suggest that may *regulate* T lymphocyte activation in response to inflammatory stimuli and migration induced by CXCR4 , CCR3 , and CCR5 , but not CCR2 or [CCR7] . Regulation CCR7 SELL 12609846 1085251 Engagement of by antibody cross linking or the L-selectin ligands fucoidan or sulfatide mobilized intracellular CXCR4 to significantly increase surface CXCR4 expression but did not *affect* CCR5 , [CCR7] , or beta2-integrin expression . Regulation CD109 SELL 9147056 429744 However , in sharp contrast to its reactivity against the silkworm LEC-IgG , p180 failed to bind LEC-IgG produced by COS-7 cells , suggesting that [p180] reacted with the silkworm LEC-IgG through the recognition of oligomannose-type oligosaccharides expressed on the silkworm products and that the lectin activity of was not *involved* in the interaction . Regulation CD14 APOB 20472010 2288543 The aim of this research was to analyze the activation of [CD14] , TLR4 , and TLR2 in *response* to minimally modified low-density ( mmLDL ) . Regulation CD14 C5 8671854 372435 We examined by flow cytometry the *effect* of in vitro and in vivo haemodialysis on cuprophane membrane and recombinant on the expression of [CD14] molecules at the surface on monocytes . Regulation CD14 CA2 12805475 1120590 Inclusion of TNF-alpha in culture media of Kupffer cells enhanced [CD14] expression , LPS induced intracellular concentration *response* , and production of TNF-alpha . Regulation CD14 CD40 10102646 602312 The *effects* of ligation on peripheral blood mononuclear cell interleukin-12 and interleukin-15 production and on monocyte [CD14] surface antigen expression in human immunodeficiency virus positive patients . Regulation CD14 CEBPA 10438498 634842 These data indicate that is directly *involved* in the regulation of [CD14] gene expression . Regulation CD14 CSF1 12153694 971630 It has been demonstrated that the expression of CD16 and [CD14] is *regulated* by macrophage colony stimulating factor ( ) and GM-CSF . Regulation CD14 CSF2 11012779 736215 Release of CD14 in the culture supernatant was decreased in the presence of GM-CSF , suggesting that a reduced shedding was responsible for the *effect* of on [CD14] expression . Regulation CD14 CSF2 11012779 736216 Enhancement of cytokine production was also observed in GM-CSF treated macrophages after stimulation by phorbol 12-myristate 13-acetate ( PMA ) , thus indicating that *affects* both [CD14 dependent and -independent] cytokine production . Regulation CD14 CSF2 11477201 841990 Down-regulation of [CD14] expression in *response* to IL-4 and was slower in cord blood monocytes than that in adult peripheral blood monocytes . Regulation CD14 CSF2 12153694 971631 It has been demonstrated that the expression of CD16 and [CD14] is *regulated* by macrophage ( M-CSF ) and GM-CSF . Regulation CD14 CSH2 11985517 935708 *Effects* of human on the expression of CD163 and [CD14] on human monocytes in culture . Regulation CD14 GGA1 18193105 1838920 When it was examined whether GGA interacts with LPS and/or *affects* expression of Toll-like receptor 4 (TLR4) and [CD14] on the cell surface , inhibited the binding of LPS to the cell surface , while GGA did not affect TLR4 and CD14 expressions . Regulation CD14 GGA2 18193105 1838918 When it was examined whether GGA interacts with LPS and/or *affects* expression of Toll-like receptor 4 (TLR4) and [CD14] on the cell surface , inhibited the binding of LPS to the cell surface , while GGA did not affect TLR4 and CD14 expressions . Regulation CD14 GGA3 18193105 1838919 When it was examined whether GGA interacts with LPS and/or affects expression of Toll-like receptor 4 (TLR4) and CD14 on the cell surface , GGA inhibited the binding of LPS to the cell surface , while did not *affect* TLR4 and [CD14] expressions . Regulation CD14 IFNG 11870620 918498 Priming with P. acnes led to a moderate , mainly *dependent* up-regulation of [CD14] . Regulation CD14 IFNG 1431309 202878 The *effects* of and bacterial lipopolysaccharide on [CD14] expression in human monocytes . Regulation CD14 IFNG 1431309 202879 The *effects* of on [CD14] expression have not been clearly established . Regulation CD14 IFNG 1431309 202880 The purpose of this investigation was to examine the *effects* of IFN-gamma alone and followed by bacterial LPS on [CD14] expression . Regulation CD14 IFNG 7909275 254134 In our model , did not up-regulate or down-regulate HER-2/neu protein expression on our targets or *affect* the level of [CD14 antigen] expression on our MDM . Regulation CD14 IGF1 11876931 893906 To investigate the *effects* of rhGH and on the [CD14] mRNA expression and cytokine secretion of peritoneal macrophages ( Mphi ) in scalded rats . Regulation CD14 IL10 15944287 1416118 STAT-1 mediates the stimulatory *effect* of on [CD14] expression in human monocytic cells . Regulation CD14 IL10 18049335 1833197 Patients were separated into 2 groups on the basis of the [CD14+] monocyte *response* : either increasing or decreasing IL-10 expression from preimmunization ( week 0 ) to week 16 blood draws . Regulation CD14 IL10 19109192 2018936 Using ELISA , we demonstrated that had a profound dose- and time related *effect* on the release of soluble MD-2 and soluble [CD14] from monocytes . Regulation CD14 IL13 7542068 310927 We investigated whether [CD14] expression is *regulated* by , a member of the chromosome 5 cytokine family . Regulation CD14 IL13 7545713 323050 We now investigate whether [CD14] expression could also be *regulated* by , another member of the chromosome 5 cytokine gene family . Regulation CD14 IL13 7545713 323053 *dependent* down-regulation of [CD14] resulted in the inhibition of CD14 mediated events . Regulation CD14 IL13 8732434 374084 We found that HLA-DR , HLA-DQ , [CD14] and CD23 were differentially *regulated* by biostim and IL-4 or . Regulation CD14 IL4 11477201 841983 thus , to further clarify the differences of monocyte function and differentiation between neonates and adults , we investigated their CD14 ( + ) CD4 ( + ) and [CD14] ( + ) CD16 ( + ) monocyte subpopulations , production of IL-1beta and tumor necrosis factor-alpha induced by lipopolysaccharide , and their CD14 and CD1a phenotypic changes in *response* to and granulocyte-macrophage colony stimulating factor . Regulation CD14 IL4 11477201 841991 Down-regulation of [CD14] expression in *response* to and GM-CSF was slower in cord blood monocytes than that in adult peripheral blood monocytes . Regulation CD14 IL4 1701391 145033 Nuclear run-off assays revealed that the *dependent* down-regulation of [CD14] resulted from decreased transcription . Regulation CD14 IL4 1717365 166764 In this study we compared the *effects* of the cytokines IL-1 , IL-6 , , and a combination of IL-1 and IL-6 on the expression of the [CD14 antigen] , the FcIIIg receptor molecule CD16 and the MHC-class II molecules HLA-DR and HLA-DP . Regulation CD14 IL4 1725131 176764 Since ( autocrine ) IL-6 is possibly involved in the proliferation and differentiation of acute myeloid leukemia cells with myelomonocytic differentiation ( AML-M4/M5 ) , we studied the *effects* of on IL-6 production and [CD14] expression by these cells . Regulation CD14 IL4 7540642 310125 Seven-day cultured monocytes/macrophages showed ( 1 ) diminished TNF-alpha production in response to IL-10 but not IL-4 ( 2 ) , diminished IL-1 beta production in response to both IL-4 and IL-10 , and compared with fresh monocytes ( 3 ) , diminished [CD14] expression in *response* to , and ( 4 ) a lesser increase in CD23 expression in response to IL-4 . Regulation CD14 IL4 7691031 228709 Instead of serum , GM-CSF was required as a co-factor to restore the regulatory *effect* of on [CD14-expression] . Regulation CD14 IL4 8732434 374085 We found that HLA-DR , HLA-DQ , [CD14] and CD23 were differentially *regulated* by biostim and or IL-13 . Regulation CD14 IL4 9317115 456237 The *effects* of LPS and on the expression of [CD14] , indicated by binding of Leu M3 Ab , and PCD of monocytes were studied simultaneously and in a kinetic fashion by multiparameter flow cytometry . Regulation CD14 IL6 17645774 1787785 When CD34 ( + ) CD38 ( - ) hematopoietic progenitors were cultured with stem cell factor , flt3 ligand , thrombopoietin and IL-3 , Delta-1 , in combination with the IL-6R/IL-6 fusion protein FP6 , increased the generation of glycophorin A ( + ) erythroid cells but counteracted the *effects* of and FP6 on the generation of [CD14] ( + ) monocytic and CD15 ( + ) granulocytic cells . Regulation CD14 ITGB2 7539546 307046 *Effects* of and LPS on [CD14] expression on human monocytes . Regulation CD14 LPA 20472010 2288544 The aim of this research was to analyze the activation of [CD14] , TLR4 , and TLR2 in *response* to minimally modified low-density ( mmLDL ) . Regulation CD14 MAPK1 12595465 1061532 The LPS receptor complex utilized by the bladder epithelial cell lines included [CD14] and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 . Regulation CD14 MAPK10 12595465 1061533 The LPS receptor complex utilized by the bladder epithelial cell lines included [CD14] and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 . Regulation CD14 MAPK11 12595465 1061534 The LPS receptor complex utilized by the bladder epithelial cell lines included [CD14] and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 . Regulation CD14 MAPK12 12595465 1061535 The LPS receptor complex utilized by the bladder epithelial cell lines included [CD14] and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 . Regulation CD14 MAPK13 12595465 1061536 The LPS receptor complex utilized by the bladder epithelial cell lines included [CD14] and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 . Regulation CD14 MAPK14 12595465 1061537 The LPS receptor complex utilized by the bladder epithelial cell lines included [CD14] and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 . Regulation CD14 MAPK15 12595465 1061531 The LPS receptor complex utilized by the bladder epithelial cell lines included [CD14] and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 . Regulation CD14 MAPK3 12595465 1061538 The LPS receptor complex utilized by the bladder epithelial cell lines included [CD14] and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 . Regulation CD14 MAPK4 12595465 1061539 The LPS receptor complex utilized by the bladder epithelial cell lines included [CD14] and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 . Regulation CD14 MAPK6 12595465 1061540 The LPS receptor complex utilized by the bladder epithelial cell lines included [CD14] and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 . Regulation CD14 MAPK7 12595465 1061541 The LPS receptor complex utilized by the bladder epithelial cell lines included [CD14] and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 . Regulation CD14 MAPK8 12595465 1061542 The LPS receptor complex utilized by the bladder epithelial cell lines included [CD14] and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 . Regulation CD14 MAPK9 12595465 1061543 The LPS receptor complex utilized by the bladder epithelial cell lines included [CD14] and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 . Regulation CD14 MUC1 22841164 2660492 We investigated whether *affects* human early pregnancy decidual [CD14] ( + ) cells and their interactions with cognate decidual natural killer ( NK ) cells . Regulation CD14 NFKB1 12595465 1061544 The LPS receptor complex utilized by the bladder epithelial cell lines included [CD14] and Toll-like receptors , and signaling *involved* the activation of and p38 mitogen activated protein kinase . Regulation CD14 PRTN3 12067299 954960 This study demonstrates that can degrade rCD14 and that PR3 differentially *affects* [CD14] expression in subsets of monocytes . Regulation CD14 RELA 12595465 1061545 The LPS receptor complex utilized by the bladder epithelial cell lines included [CD14] and Toll-like receptors , and signaling *involved* the activation of and p38 mitogen activated protein kinase . Regulation CD14 RELB 15315978 1333343 Here we demonstrate that the nuclear factor-kappaB (NF-kappaB) *regulates* the generation of monocytic [CD14] ( + ) CD11b ( + ) precursors of interstitial DCs from human hematopoietic progenitors . Regulation CD14 SELP 12847232 1108944 *effects* on enhancing [CD14] ( + ) CD16 ( + ) DLC generation were completely abrogated by pretreatment of cells with the protein kinase C delta inhibitor rottlerin , but not by classical protein kinase C inhibitor Gö6976 . Regulation CD14 SERPINA1 17448722 1749601 *regulates* CD14 expression and soluble [CD14] levels in human monocytes in vitro . Regulation CD14 SFTPD 15814723 1393131 *regulates* soluble [CD14] through matrix metalloproteinase-12 . Regulation CD14 SP1 17203216 1681231 In addition , we investigated whether the myeloid *played* a role in decitabine- and VD3 induced [CD14] expression . Regulation CD14 SP1 7512565 250370 Mutation of the major Sp1 binding site ( -110 bp ) decreased tissue-specific promoter activity , and these results , together with transactivation experiments , demonstrate that *plays* a critical role in the tissue-specific expression of [CD14] in monocytic cells . Regulation CD14 SP1 9125541 426453 The *plays* a crucial role in the monocyte-specific expression of [CD14] , a binding site ( or putative receptor ) for lipopolysaccharide (LPS) complexes with LPS binding protein (LBP) . Regulation CD14 TGFB1 7526045 277084 To study the *effect* of on monocyte [CD14] expression , human leukocytes were isolated from healthy donors with discontinuous gradient centrifugation and incubated at 37 degrees C for 2 and 24 hr with increasing doses of purified human platelet TGF-beta 1 . Regulation CD14 TGFB1 7526045 277086 Thus , CD14 may be marker for the transition of monocytes to macrophages and may be *responsible* for the down-regulation of [CD14] expression observed in monocytes obtained from septic patients . Regulation CD14 TLR4 23201091 2730685 In conclusion , these studies show for the first time that LPS causes an increase in intestinal permeability via an intracellular mechanism involving *dependent* up-regulation of [CD14] membrane expression . Regulation CD14 TNF 10777809 686979 *Role* of microglial derived in mediating [CD14] transcription and nuclear factor kappa B activity in the brain during endotoxemia . Regulation CD14 TNF 10777809 686980 The present data provide the evidence that microglial derived is *responsible* for the production of the LPS receptor [CD14] during endotoxemia . Regulation CD14 TNF 10843415 700071 The *effects* of human recombinant on neutrophil ( PMNL ) oxidative burst and on CD11b/CD18 and [CD14] expression after stimulation with pathogenic or nonpathogenic Neisseria meningitidis were studied using chemiluminescence and flow cytometry . Regulation CD14 TNF 12101079 962453 No association was found between the CD14 -260 genotypes or the TNF-alpha -308 - [CD14] -260 genotypes and the *response* . Regulation CD14 TNF 15256426 1322062 Using neutralizing antibodies against m-CSF-1R or its ligand , we found that inhibiting this pathway strongly reduced [CD14] expression in *response* to RA and , suggesting that this pathway is essential for their synergy in RA-resistant leukemia cells . Regulation CD14 TNF 7684764 219676 The increases in CR3 and [CD14] occurred in parallel and were *independent* of protein synthesis and production . Regulation CD14 TNF 8921956 396878 Furthermore , exogenous recombinant tumor necrosis factor (TNF) induced in vivo and in vitro enhanced CD14 expression in Lpsn , Lpsd and also in TNF receptor 2-deficient (TNFR2-/-) mice , but failed to do so in TNFR1-/- mice , showing that TNFR1 mediates the *effect* of on [CD14] . Regulation CD14 TYR 17977838 1850285 These findings reveal *roles* of Phe ( 121 ) and ( 131 ) in TLR4 independent interactions of human MD-2 with E . [CD14] and , together with Phe ( 126 ) , in activation of TLR4 by bound E . MD-2 . Regulation CD19 CD22 10485654 644324 Biochemical studies with B cells from CD19-deficient and CD22-deficient mice indicated that these two regulatory molecules influenced each other 's functions : expression negatively *regulated* [CD19] tyrosine phosphorylation , while optimal CD22 function was dependent on CD19 expression . Regulation CD1A TLR7 18310500 1919414 Sorafenib , but not sunitinib , inhibits function of DCs , characterized by reduced secretion of cytokines and expression of [CD1a] , major histocompatibility complex , and costimulatory molecules in *response* to ligands as well as by their impaired ability to migrate and stimulate T-cell responses . Regulation CD200 TLR7 22615569 2603881 [CD200] receptor *controls* sex-specific responses to viral infection . Regulation CD22 CD19 11339363 765252 complex formation also *regulates* phosphorylation of [CD22] and FcgammaRIIB , which inhibit B cell signal transduction through the recruitment of the SHPI and SHIP phosphatases . Regulation CD22 CD19 17223015 1703665 *regulates* [CD22] phosphorylation by augmenting Lyn kinase activity , while CD22 inhibits CD19 phosphorylation via SHP-1 . Regulation CD22 CD40 16393971 1505962 B cell antigen receptor and differentially *regulate* [CD22] tyrosine phosphorylation . Regulation CD22 LYN 11339363 765253 complex formation also *regulates* phosphorylation of [CD22] and FcgammaRIIB , which inhibit B cell signal transduction through the recruitment of the SHPI and SHIP phosphatases . Regulation CD22 LYN 17223015 1703666 CD19 *regulates* [CD22] phosphorylation by augmenting kinase activity , while CD22 inhibits CD19 phosphorylation via SHP-1 . Regulation CD22 LYN 9601638 506579 In contrast , *plays* a particularly important role in the tyrosine phosphorylation of [CD22] and in the consequent inhibition of BCR induced calcium influx . Regulation CD22 PTPN6 8627166 355816 These results suggest that tyrosyl phosphorylated CD22 may be a substrate for *regulates* tyrosyl phosphorylation of [CD22] . Regulation CD22 PTPRC 10228003 610549 *regulates* tyrosine phosphorylation of [CD22] and its association with the protein tyrosine phosphatase SHP-1 . Regulation CD22 PTPRC 10228003 610555 These results indicate that *regulates* tyrosine phosphorylation of [CD22] and binding of SHP-1 . Regulation CD22 PTPRC 7684411 217573 [CD22] mediated adhesion of cell lines to COS-CD22 cells was *independent* of and CDw75 expression , and it was not inhibited by mAb against known integrins . Regulation CD22 PTPRC 7814873 292801 These observations collectively suggest that binding of NK3.3 cells to [CD22] may be *independent* of on NK3.3 cells . Regulation CD24 EPHB2 22800863 2660116 Our results suggest that down-regulation of signaling via Src/FAK may be dependent on integrin ß1 function and that this mechanism is largely *responsible* for the [CD24] ablation induced decreases in cell proliferation and epithelial to mesenchymal transition . Regulation CD24 MAP2K6 22800863 2660122 Our results suggest that down-regulation of signaling via Src/FAK may be dependent on integrin ß1 function and that this mechanism is largely *responsible* for the [CD24] ablation induced decreases in cell proliferation and epithelial to mesenchymal transition . Regulation CD27 TNF 10221513 609432 In contrast to results described with B-type chronic lymphocytic leukemia , also characterized by high levels of circulating TNF , none of the tested samples showed a regulation of CD80 , CD86 , [CD27] and CD70 in *response* to . Regulation CD274 EPHB2 24606459 2925156 The *effects* of an inhibitor on [B7-H1] expression and CTL cytotoxicity against T24 cells were also evaluated . Regulation CD28 NT5E 21677139 2451342 Activation of T cells by [CD3/CD28] cross linking could be inhibited by exogenously added 5'AMP in a *dependent* manner . Regulation CD34 SELL 11239168 791810 We conclude that release of [CD34] ( + ) cells to the PB *involves* a general downregulation of Thy1 , and VLA-4 on CD34 ( + ) cells , irrespective of the growth factor used for mobilization . Regulation CD34 TLR7 19244164 2086568 Furthermore , NOD2 stimulation enhanced the [CD34+] *response* to ligands ( e.g. , LPS , palmitoyl-3-cysteine-serine-lysine-4 ) and increased intracellular alpha-defensin protein levels . Regulation CD36 ALOX5 19135147 2031976 This study investigated the *role* of <5-LO> in HNE induced [CD36] expression and macrophage foam cell formation , and the link between HNE and 5-LO . Regulation CD36 ALOX5 19135147 2031979 In peritoneal macrophages from 5-LO-deficient mice , HNE induced CD36 expression was markedly attenuated , confirming a pivotal *role* of <5-LO> in HNE induced [CD36] expression . Regulation CD36 ALOX5 19885004 2160998 In addition , HNE enhanced expression of CD36 was reduced by these inhibitors , which indicated a *role* for NADPH oxidase and <5-LO> on [CD36] expression . Regulation CD36 RCAN1 24127415 2875059 *regulates* [CD36] expression and its genetic inactivation reduced atherosclerosis extension and severity in Apoe ( -/- ) mice . Regulation CD36 TNF 17335569 1760086 We investigated the *role* of and adalimumab , a human anti-TNFalpha monoclonal antibody widely used in human pathology , in [CD36] expression in human monocytes . Regulation CD36 TNF 20223233 2254378 SAMe prevented the increase in the TNFalpha and IFNgamma receptors , supporting the idea that and IFNgamma were *responsible* for the up regulation of LMP2 , LPM7 , and [FAT10] . Regulation CD38 PECAM1 19956559 2217347 [CD38-receptor] activities are *regulated* through binding to the nonsubstrate ligand . Regulation CD38 TNF 14563702 1199806 Furthermore , we investigated *regulation* of oxytocin induced [Ca2+ ] i transients , [CD38] cyclase activity , and CD38 expression in human myometrial cells . Regulation CD38 TNF 16571778 1555989 Transcriptional *regulation* of [CD38] expression by in human airway smooth muscle cells : role of NF-kappaB and sensitivity to glucocorticoids . Regulation CD38 TNF 18178673 1863030 In the present study , we tested the hypothesis that the *effects* of on [CD38] expression vs. changes in [ Ca ( 2+ ) ] ( i ) regulation in ASM cells are linked . Regulation CD3D JAG1 17277165 1697947 All tested patients shared similar immunological features such as a partial [TCR/CD3] expression defect , mild alphabeta and gammadelta T lymphocytopenia , poor in vitro proliferative *responses* to and mitogens at diagnosis , and very low TCR rearrangement excision circles and CD45RA ( + ) alphabeta T cells . Regulation CD3E JAG1 17277165 1697948 All tested patients shared similar immunological features such as a partial [TCR/CD3] expression defect , mild alphabeta and gammadelta T lymphocytopenia , poor in vitro proliferative *responses* to and mitogens at diagnosis , and very low TCR rearrangement excision circles and CD45RA ( + ) alphabeta T cells . Regulation CD3G JAG1 17277165 1697949 All tested patients shared similar immunological features such as a partial [TCR/CD3] expression defect , mild alphabeta and gammadelta T lymphocytopenia , poor in vitro proliferative *responses* to and mitogens at diagnosis , and very low TCR rearrangement excision circles and CD45RA ( + ) alphabeta T cells . Regulation CD4 CD14 24866794 2945616 Collectively , these data identify a previously unrecognized *role* for in regulating macrophage plasticity and [CD4] ( + ) T cell biasing during helminth infection . Regulation CD4 FAS 11509617 848599 However , inhibition of perforin activity , the interaction , or both CTL mechanisms did not *affect* [CD4] ( + ) and CD8 ( + ) T cell mediated restriction of MTB growth . Regulation CD4 FAS 11509617 848604 Thus , perforin and were not *involved* in [CD4] ( + ) and CD8 ( + ) T cell mediated restriction of MTB growth . Regulation CD4 FAS 15322178 1286790 Our results reveal an important *dependent* mechanism for the regulation of hapten-specific [CD4] ( + ) T cell responses by CD8 ( + ) T cells , which causes the dominance of CD8 ( + ) effector T cells and the active suppression of a CD4 ( + ) T cell response . Regulation CD4 FAS 15788440 1425030 The enhanced [CD4] ( + ) T cell death with a suppressive dose of Con A is dependent on excess H ( 2 ) O ( 2 ) and nitric oxide but is *independent* of and caspase activity . Regulation CD4 FAS 8924258 371607 To analyse the *role* of the apoptosis inducing receptor in the depletion of [CD4+] and CD8+ T cells in HIV infected individuals . Regulation CD4 ITGAL 15778396 1385099 These results indicate a prominent *role* for HLA-DP and in BAL [CD4] ( + ) T cell activation and further suggest that specific Abs to these molecules could serve as a possible therapy for chronic beryllium disease . Regulation CD4 ITGB2 15383575 1298951 We examined the *role* of in [CD4] ( + ) T cell activation in vivo by using a system that allows for segregation of the migration and activation defects through the adoptive transfer of LFA-1-deficient ( CD18 ( -/- ) ) CD4 ( + ) T cells from DO11.10 Ag-specific TCR transgenic mice into wild-type BALB/c mice . Regulation CD4 JAG1 10203056 606133 Previous studies revealed that monotherapy with ritonavir , a protease inhibitor , resulted in a slight improvement in memory [CD4+] T cell *responses* to recall only when detectable prior to onset of therapy , suggesting that the loss of CD4+ T cell reactivity might be irreversible at advanced stages of the disease [ 2 ] . Regulation CD4 JAG1 10553046 565479 Analysis of responses to endogenous superantigens , which are known to be strongly dependent on B cells for presentation , indicated that [CD4+] *responses* to strong are less dependent on CD40 than are responses to weak Ags . Regulation CD4 JAG1 10553102 565570 The low precursor frequency of Ag-reactive CD4+ T cells has been a barrier to the study of CD4+ T cell responses to conventional as well as [CD4+] T cell *responses* to autoantigens recognized during the course of an autoimmune disease . Regulation CD4 JAG1 10975814 729402 The costimulatory receptor OX40 has recently been shown to be involved in primary [CD4] *responses* to several defined . Regulation CD4 JAG1 19380765 2065674 The findings were striking and indicated that blockade of CD59 significantly enhanced the [CD4] ( + ) T cell *response* to two different tumor . Regulation CD4 JAG1 21187441 2378920 Both RIG-I dependent cytokine production and [CD4] T cell *responses* to SeV derived helper are indispensable for overcoming regulatory T cell suppression to prime melanoma Ag recognized by T cell-1-specific CTL in the regulatory T cell abundant setting . Regulation CD4 JAG1 21918192 2491975 tumor rejection requires IL-17 , which is produced by IFN-?-deficient [CD4] ( + ) T cells in *response* to tumor ( TAs ) . Regulation CD4 JAG1 23719937 2838477 Few Mtb interacting with DCs *affect* priming , activation , and regulation of Ag-unrelated [CD4] ( + ) T-cell responses . Regulation CD4 JAG1 9278299 450846 As the disease progresses , by wk 8 of infection , [CD4] T cell *response* to and mitogens is severely curtailed and the CD4 T cell population becomes anergic . Regulation CD4 MMP28 20639459 2418943 Intracellular calcium flux was augmented in *response* to inhibition or deficiency in the same cells , and IL-2 production was reduced in [CD4] ( + ) and CD8 ( + ) MMP9 ( -/- ) T cells . Regulation CD4 MMP7 20639459 2418958 Intracellular calcium flux was augmented in *response* to inhibition or deficiency in the same cells , and IL-2 production was reduced in [CD4] ( + ) and CD8 ( + ) MMP9 ( -/- ) T cells . Regulation CD4 SELL 23658623 2784739 Curcumin not merely blocks , but *regulates* CD2/CD3/CD28 initiated [CD4] ( + ) T cell activation by augmenting CD69 , CCR7 , and TGF-ß1 expression followed by regulatory T cell generation . Regulation CD4 TCN1 10910289 713975 Here , we compared the capacity of in vitro generated normal liver immature DC and FL-treated donor liver DC to induce alloimmune [CD4+] T helper (Th) 1/Th2 and CD8+ *responses* , in vitro and in vivo . Regulation CD4 TCN1 15557623 1340872 IL-12 p40 levels in serum and magnitudes of [CD4+] Th1 and CD8+ *responses* against Listeria antigen were significantly higher in AC-1 treated mice than in PBS treated mice . Regulation CD4 TF 1569393 187086 Results show that both [CD4+] and CD8+ T clones can process and present HBenvAg to class II-restricted cytotoxic T lymphocytes and that the CD71 is *involved* in efficient HBenvAg uptake by T cells . Regulation CD4 TLR7 16034093 1436261 We also observed that [CD4+CD45RO+] memory T cell *responses* to ligands were more potent than those observed with CD4+CD45RA+ naive T cells . Regulation CD4 TLR7 19843574 2187460 Although signaling through certain TLRs is known to modulate the function of T lymphocytes , the *effect* of stimulation on [CD4] ( + ) CD25 ( + ) T ( reg ) cell activity has not yet been elucidated . Regulation CD4 TNF 12221281 987610 *regulation* of [CD4+CD25+] T cell levels in NOD mice . Regulation CD4 TNF 15517626 1328665 A similar pattern was seen in positive [CD4] T cell *responses* . Regulation CD4 TNF 1628901 191840 In this study we investigated the *effects* of and IFN-gamma on the expression of the [CD4] protein and messenger RNA ( mRNA ) in the two myeloid cell lines , ML3 and HL-60 . Regulation CD4 TNF 17409152 1742129 Indirect *regulation* of [CD4] T-cell responses by receptors in an acute viral infection . Regulation CD4 TNF 2161875 135841 did not *affect* the expression of LFA1 , CD2 , [CD4] , and CD8 , molecules that are associated with CTL-target interactions , on responder cells . Regulation CD4 TNF 22355730 2561310 PMA/ionomycin stimulated [CD4] T cell *responses* were decreased in patients with smear positive tuberculosis compared to those with smear negative tuberculosis . Regulation CD4 TNF 9698257 524882 IL-1-alpha and differentially *regulate* [CD4] and Mac-1 expression in mouse microglia . Regulation CD4 TNFSF10 19008314 2047182 In the present study , we specifically examined *effects* on [CD4] ( + ) CD25 ( + ) regulatory T cells . Regulation CD40 ALOX5 21200133 2391701 We describe an alternative ROS production pathway that is triggered by [CD40] ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 MAPK . Regulation CD40 CD22 16393971 1505965 By contrast , anti-CD40 stimulation specifically up-regulated anti-IgM induced phosphorylation of tyrosines within two ITIM motifs , Y762 and Y842 , which was consistent with in vivo finding of the negative *role* of in [CD40] signaling . Regulation CD40 TLR7 18006661 1827276 Here , we show that human beta-defensin-3 (hBD-3) , an innate antimicrobial peptide , can induce expression of the costimulatory molecules CD80 , CD86 , and [CD40] , on monocytes and myeloid dendritic cells in a *dependent* manner . Regulation CD40 TNF 11508577 848193 We examined the *effects* of IFN-gamma , , and granulocyte-macrophage colony stimulating factor ( GM-CSF ) on [CD40] expression on CD68+ synovial macrophage-lineage cells (SMC) . Regulation CD40 TNF 11830590 928978 Critical *role* of and NF-kappa B in interferon-gamma -induced [CD40] expression in microglia/macrophages . Regulation CD40 TNF 17507688 1772763 IFN-gamma induced [CD40] expression *involves* activation of STAT-1alpha as well as NF-kappaB activation through an autocrine response to IFN-gamma induced production . Regulation CD40 TNF 20006573 2199865 *regulates* [CD40] expression through SMAR1 phosphorylation . Regulation CD40 TNF 20808842 2314349 PPR dependent stimulation of TNF production by T cells and the resulting *regulation* of [CD40] signaling in SCs are potential new therapeutic targets for the bone loss of hyperparathyroidism . Regulation CD40 TNF 22010829 2539714 These results reveal an important *role* of induction in [CD40] 's chemosensitization activity and suggest that modulating TNF-a autocrine from cancer cells is an effective option for increasing the anticancer value of chemotherapeutics such as cisplatin . Regulation CD40 TNF 9205097 440479 Epstein-Barr virus encoded LMP1 and [CD40] mediate IL-6 production in epithelial cells via an NF-kappaB pathway *involving* receptor associated factors . Regulation CD40LG HES2 19935110 2203849 The *effects* of mannitol and on [CD40L] expression were almost identical and were superior to those of 3 % saline . Regulation CD40LG TNF 12689942 1106076 cDNA microarray studies using the CNIO OncoChip of 29 MF and 11 ID cases revealed a signature of 27 genes implicated in the tumorigenesis of MF , including *dependent* apoptosis regulators , STAT4 , [CD40L] , and other oncogenes and apoptosis inhibitors . Regulation CD44 IL1B 15901130 1409114 The expression of [CD44] is *regulated* by , but binding of HMGA1 potentiates the transactivation of the CD44 promoter . Regulation CD44 IL1B 9197378 438553 In addition , pretreatment of infected monocytes with a TNF-alpha synthesis inhibitor , RP 55778 , or with MAbs directed against IL-1beta , confirmed the *role* of TNF-alpha and in the regulation of CD18 , [CD44] , and CD54 expression . Regulation CD44 IL1B 9685385 522054 *Regulation* of [CD44] gene expression by the proinflammatory cytokine in vascular smooth muscle cells . Regulation CD44 IL1B 9685385 522056 *Regulation* of [CD44] gene expression by the proinflammatory cytokine may contribute to SMC phenotypic modulation in the pathogenesis of arteriosclerosis . Regulation CD44 ITGB2 8095198 211905 Despite higher ICAM-1 levels , cell aggregation assays revealed that adhesive interactions were not *involved* in the homotypic adhesion of B9/BM1 cells but rather that binding of [CD44] to endogenously synthesized hyaluronan was responsible . Regulation CD44 SPHK1 23426175 2760033 *plays* a role in the upregulation of [CD44] expression through extracellular signal regulated kinase signaling in human colon cancer cells . Regulation CD44 SPHK1 23426175 2760034 The *regulation* of [CD44] by was examined by either blocking or overexpressing SPHK1 and by using an L-OHP-resistant HCT116 clone ( HCT116-R ) . Regulation CD44 TNF 10933610 720328 This study used flow cytometry to assess the *effects* of recombinant IFN-gamma and on [CD44] expression and hyaluronan binding by the rat small intestinal epithelial cell lines , RIE and IEC 6 . Regulation CD44 TNF 12090473 960026 and IL-8 *regulate* the expression and function of [CD44] variant proteins in human colon carcinoma cells . Regulation CD44 TNF 12421945 1013714 Differential *regulation* of [CD44] expression by lipopolysaccharide (LPS) and in human monocytic cells : distinct involvement of c-Jun N-terminal kinase in LPS induced CD44 expression . Regulation CD44 TNF 12867430 1141881 In this study , we show that LPS induced [CD44 mediated HA (CD44-HA)] binding in monocytes is *regulated* by endogenously produced and IL-10 . Regulation CD44 TNF 12867430 1141900 LPS induced [CD44-HA] binding in THP-1 cells was *regulated* by endogenously produced . Regulation CD44 TNF 12867430 1142114 Taken together , our results suggest that induced p38 MAPK activation may *regulate* the induction of functionally active HA-binding form of [CD44] by activating sialidase in LPS stimulated human monocytic cells . Regulation CD44 TNF 16908592 1601622 However , little is known about the *role* of in [CD44] expression of cancer cells . Regulation CD44 TNF 16908592 1601624 We studied the *effect* of on ovarian cancer cells viability , [CD44] expression , and in vitro migration/invasion . Regulation CD44 TNF 22386367 2572486 *Regulation* of [CD44] expression by and its potential role in breast cancer cell migration . Regulation CD44 TNF 22386367 2572487 In the current investigation , we investigated the *effect* of on BC cells ( MCF-7 and MDA-MB-231 ) viability , [CD44] expression , and in vitro migration . Regulation CD44 TNF 7542295 314091 We examined the modulatory *effects* of and interleukin (IL)-10 on the [CD44] expression in LC . Regulation CD44 TNF 7542295 314097 These data suggest that in the epidermal microenvironment the expression of [CD44] in LC may be reciprocally *regulated* by and IL-10 , both of which are known to be produced by surrounding keratinocytes . Regulation CD44 TNF 9197378 438552 In addition , pretreatment of infected monocytes with a TNF-alpha synthesis inhibitor , RP 55778 , or with MAbs directed against IL-1beta , confirmed the *role* of and IL-1beta in the regulation of CD18 , [CD44] , and CD54 expression . Regulation CD46 MIP 16387335 1567078 LTA produced a dose related increase in early pulmonary inflammation , which was characterized by ( 1 ) influx of polymorphonuclear neutrophils ( PMNs ) and ( 2 ) induction of interleukin (IL)-6 , tumor necrosis factor (TNF)-alpha , , but no *effect* on [monocyte chemoattractant protein (MCP)-1/CCL2] at 24 h after instillation . Regulation CD46 TNF 16081883 1466274 In vitro analysis indicates that alveolar cell expression of TNF-R2 is critical in the induction of epithelial [monocyte chemoattractant protein (MCP)-1] expression specifically in *response* to soluble , suggesting an important role for this receptor in bystander lung injury . Regulation CD46 TNF 16387335 1567076 LTA produced a dose related increase in early pulmonary inflammation , which was characterized by ( 1 ) influx of polymorphonuclear neutrophils ( PMNs ) and ( 2 ) induction of interleukin (IL)-6 , , macrophage inflammatory protein (MIP)-1alpha/CCL3 , but no *effect* on [monocyte chemoattractant protein (MCP)-1/CCL2] at 24 h after instillation . Regulation CD55 TNF 9155641 431611 In this study , we examined the *effects* of on [DAF] expression in three intestinal epithelial cell lines . Regulation CD55 TNF 9155641 431612 In HT-29 cells , the *effects* of on [DAF] mRNA accumulation were observed in a dose dependent manner ; Regulation CD55 TNF 9155641 431614 Messenger RNA stability studies suggested that partially *regulated* [DAF] gene expression by a posttranscriptional mechanism . Regulation CD58 TNF 9255503 447717 Neither IFN-gamma nor had any *effect* on [LFA-3] expression on the cultured HCE cells . Regulation CD69 ALOX5 11200053 779747 It is suggested that <5-LO> *plays* a critical role in the induction of [CD69] on eosinophils . Regulation CD70 TNF 10221513 609433 In contrast to results described with B-type chronic lymphocytic leukemia , also characterized by high levels of circulating TNF , none of the tested samples showed a regulation of CD80 , CD86 , CD27 and [CD70] in *response* to . Regulation CD79A AGR2 1937766 170363 At least two to three intragastric doses of 15 micrograms or more of Ag I/II-CTB conjugate , plus free CT as an adjuvant , were needed to induce the salivary [IgA] *response* , which peaked at about 35 days and persisted at lower levels for 5 to 6 months . Regulation CD79A CD22 16497829 1535284 This points to a new mechanism of [BCR] signal *regulation* by and its ligand . Regulation CD79A CD22 17223015 1703659 CD19 and do not merely *regulate* [BCR] signals independently , but they have their own regulatory network . Regulation CD79A CD22 17631277 1775243 Previous studies demonstrated that synthetic sialosides that bind to CD22 augment BCR signaling by inhibiting mediated [BCR] *regulation* . Regulation CD79A CD22 18024433 1851817 We demonstrate that the mutant in which both Tyr ( 843 ) and Tyr ( 863 ) are replaced by phenylalanine ( CD22F5/6 ) recruits SHP-1 and *regulates* [BCR] signaling upon stimulation with antigen but not anti-Ig Ab . Regulation CD79A CD22 9371816 466179 Ligation of CD19 and in vivo is likely to positively and negatively *regulate* [BCR] signaling , respectively , because CD19 crosslinking was more efficient than BCR crosslinking at inducing Vav phosphorylation . Regulation CD79A COL17A1 11040070 741886 Patients with bullous pemphigoid and linear IgA disease show a dual [IgA] and IgG autoimmune *response* to . Regulation CD79A COL17A1 11040070 741887 Our findings clearly demonstrate that both BP and LAD patients have a dual [IgA] and IgG autoimmune *response* to which is directed not only to the ectodomain , but also to the intracellular portion of this protein . Regulation CD79A CTGF 15012739 1183024 The present study was designed to elucidate the *role* of in diabetic nephropathy (DN) , [immunoglobulin A nephropathy (IgA-N)] , membranous nephropathy ( MN ) , and minimal change nephrotic syndrome ( MCNS ) . Regulation CD79A EPHB2 16210057 1464410 Eosinophil interaction with soluble [S-IgA] likely *involves* FcalphaRI ( CD89 ) and pathway activation . Regulation CD79A EPHB2 24958853 2947343 Our findings indicate that in immature B cells , basal activation of Ras and are *controlled* by tonic [BCR] signaling , and that positive changes in Ras activity can lead to a break in both central and peripheral B-cell tolerance . Regulation CD79A IFI27 11920258 894495 This enhanced [BCR/ABL] mediated growth inhibition occurred over a range of growth factor concentrations and was *independent* of changes in p21(Cip1) and ( Kip ) levels . Regulation CD79A IFI27 9419166 480842 Induction of Th2 cytokine expression for [IgA] B cell *responses* after targeted lymph node immunization with simian immunodeficiency virus antigens in rhesus macaques . Regulation CD79A JAG1 15153542 1250184 The overexpression of Bcl-2 in B cells selectively enhances systemic [IgA] immune *responses* to T-dependent . Regulation CD79A JAG1 16113285 1448725 The salivary [immunoglobulin A (IgA)] antibody *responses* to S. mutans were characterized in 21 pairs of 5- to 13-month-old children . Regulation CD79A PECAM1 23233201 2724499 is *involved* in [BCR/ABL] signaling and may downregulate imatinib induced apoptosis of Philadelphia chromosome positive leukemia cells . Regulation CD79A PIGR 19925828 2197993 The increased expression of in the proximal segment appears primarily *responsible* for the increased secretory [IgA] levels in the small intestine of mice . Regulation CD79A TLR7 20450285 2257188 T cell dependent and -independent [IgA] responses : *role* of signalling . Regulation CD79A TLR7 20450285 2257208 Herein we review recent data , which points to a pivotal *role* of signalling in controlling T-cell dependent and independent [IgA] responses both at mucosal and systemic levels . Regulation CD79A TNF 18363466 1887868 Parenteral nutrition inhibits mediated [IgA] *response* to injury . Regulation CD79A TNF 18363466 1887873 is *involved* in the respiratory [IgA] immune response to injury . Regulation CD79A TNF 21145571 2531516 Expt 3 : and IL-1ß blockade did not *affect* the SIWF [IgA] increase after injury . Regulation CD79A TNF 23664637 2827825 Plasma interleukin-1 (IL-1) , ( TNF ) a , neopterin and the [IgA] *responses* to Gram negative bacteria were measured . Regulation CD79A TNF 24131174 2863875 The data suggest that the associations between [IgA] to MAA-LDL and markers of glucose metabolism were *independent* of but dependent on components of the metabolic syndrome . Regulation CD79A TNF 9338552 458424 These results suggest that may be *involved* in the regulation of IgG and [IgA] production and can be associated with an arrest of IgG and IgA switch of B cells in hypogammaglobulinemia . Regulation CD79B CD22 16497829 1535285 This points to a new mechanism of [BCR] signal *regulation* by and its ligand . Regulation CD79B CD22 17223015 1703661 CD19 and do not merely *regulate* [BCR] signals independently , but they have their own regulatory network . Regulation CD79B CD22 17631277 1775244 Previous studies demonstrated that synthetic sialosides that bind to CD22 augment BCR signaling by inhibiting mediated [BCR] *regulation* . Regulation CD79B CD22 18024433 1851818 We demonstrate that the mutant in which both Tyr ( 843 ) and Tyr ( 863 ) are replaced by phenylalanine ( CD22F5/6 ) recruits SHP-1 and *regulates* [BCR] signaling upon stimulation with antigen but not anti-Ig Ab . Regulation CD79B CD22 9371816 466181 Ligation of CD19 and in vivo is likely to positively and negatively *regulate* [BCR] signaling , respectively , because CD19 crosslinking was more efficient than BCR crosslinking at inducing Vav phosphorylation . Regulation CD79B EPHB2 24958853 2947347 Our findings indicate that in immature B cells , basal activation of Ras and are *controlled* by tonic [BCR] signaling , and that positive changes in Ras activity can lead to a break in both central and peripheral B-cell tolerance . Regulation CD79B IFI27 11920258 894497 This enhanced [BCR/ABL] mediated growth inhibition occurred over a range of growth factor concentrations and was *independent* of changes in p21(Cip1) and ( Kip ) levels . Regulation CD79B PECAM1 23233201 2724500 is *involved* in [BCR/ABL] signaling and may downregulate imatinib induced apoptosis of Philadelphia chromosome positive leukemia cells . Regulation CD80 IL1B 17359392 1712655 Next , we examined the *effect* of , TNF-alpha , ( IFN-gamma ) , IL-4 alpha , IL-13 and diesel exhaust particles ( DEP ) on the HLA-DR , [CD80] and CD86 expression in cultured nasal epithelial cells ( CNEC ) , by flow cytometry . Regulation CD80 TLR7 18006661 1827286 Here , we show that human beta-defensin-3 (hBD-3) , an innate antimicrobial peptide , can induce expression of the costimulatory molecules [CD80] , CD86 , and CD40 , on monocytes and myeloid dendritic cells in a *dependent* manner . Regulation CD80 TNF 10221513 609434 In contrast to results described with B-type chronic lymphocytic leukemia , also characterized by high levels of circulating TNF , none of the tested samples showed a regulation of [CD80] , CD86 , CD27 and CD70 in *response* to . Regulation CD80 TNF 11302869 803628 In contrast , , interleukin 1beta (IL1beta) , IL2 , and IL4 had no *effect* on either [CD80] or CD86 levels . Regulation CD80 TNF 17359392 1712653 Next , we examined the *effect* of IL-1beta , , ( IFN-gamma ) , IL-4 alpha , IL-13 and diesel exhaust particles ( DEP ) on the HLA-DR , [CD80] and CD86 expression in cultured nasal epithelial cells ( CNEC ) , by flow cytometry . Regulation CD81 PCSK9 19489072 2102866 Because the LDLR is suspected to be involved in hepatitis C virus ( HCV ) entry , we also tested whether can *affect* the levels of [CD81] , a major HCV receptor . Regulation CD82 TNF 11212267 785831 The present study examined whether , which mediates many of the cellular responses associated with inflammatory reactions or cancer progression , can *affect* the [KAI1/CD82] expression in lung cancer cells and , if so , whether nuclear factor (NF)-kappaB , a key molecule in TNF mediated gene expression , is involved in the mechanism of KAI1/CD82 induction . Regulation CD83 EPHB2 15454113 1301145 These results suggest that PA and TNF-alpha induce the up-regulation of [CD83] and that their action is *regulated* by and JNK . Regulation CD86 ADRB2 12055247 951800 B cell receptor- and induced *regulation* of [B7-2] ( CD86 ) expression in B cells . Regulation CD86 IL1B 17359392 1712658 Next , we examined the *effect* of , TNF-alpha , ( IFN-gamma ) , IL-4 alpha , IL-13 and diesel exhaust particles ( DEP ) on the HLA-DR , CD80 and [CD86] expression in cultured nasal epithelial cells ( CNEC ) , by flow cytometry . Regulation CD86 IL1B 9003248 410610 IFN gamma was a weak inducer of B7-2 mRNA and immunoreactivity in microglia primary cultures obtained from the neonatal mouse brain , whereas lipopolysaccharide , tumour necrosis factor-alpha , colony stimulating factors and did not *affect* microglial [B7-2] expression . Regulation CD86 TLR7 18006661 1827296 Here , we show that human beta-defensin-3 (hBD-3) , an innate antimicrobial peptide , can induce expression of the costimulatory molecules CD80 , [CD86] , and CD40 , on monocytes and myeloid dendritic cells in a *dependent* manner . Regulation CD86 TNF 11302869 803631 In contrast , , interleukin 1beta (IL1beta) , IL2 , and IL4 had no *effect* on either CD80 or [CD86] levels . Regulation CD86 TNF 17359392 1712656 Next , we examined the *effect* of IL-1beta , , ( IFN-gamma ) , IL-4 alpha , IL-13 and diesel exhaust particles ( DEP ) on the HLA-DR , CD80 and [CD86] expression in cultured nasal epithelial cells ( CNEC ) , by flow cytometry . Regulation CD8A CEACAM6 23603913 2790049 These findings suggest that *plays* an important role in the regulation of [CD8+] T-cell responses against multiple myeloma ; Regulation CD8A FAS 11509617 848600 However , inhibition of perforin activity , the interaction , or both CTL mechanisms did not *affect* CD4 ( + ) and [CD8] ( + ) T cell mediated restriction of MTB growth . Regulation CD8A FAS 11509617 848605 Thus , perforin and were not *involved* in CD4 ( + ) and [CD8] ( + ) T cell mediated restriction of MTB growth . Regulation CD8A FAS 21297009 2420018 The decrease in the numbers of [CD8] ( + ) DCs required iNKT cells but was *independent* of perforin , , or IFN-? , as it was observed in mice deficient in each of these molecules . Regulation CD8A FOXO1 23932570 2830922 The transcription factor *controls* central-memory [CD8+] T cell responses to infection . Regulation CD8A IFI27 17184540 1663799 Both the tenofovir treated and untreated macaques infected with SIVmac239Deltanef had antibody responses to SIV gp130 and antigens and SIV-specific [CD8+] T cell *responses* prior to SIVmac055 challenge , but only those animals receiving concurrent treatment with tenofovir resisted infection with SIVmac055 . Regulation CD8A IFI27 20200542 2265360 However , silencing of Foxp3 reduced expression of Foxp3 , and PD1-all of which are *involved* in the suppressive capacity of [CD8] ( + ) Treg in this model . Regulation CD8A IFI27 21326316 2453108 Our findings indicate a potential *role* for in the suppressive capacity of peptide induced regulatory [CD8] ( + ) Ti cells through effects on the expression of Foxp3 and the synthesis of TGFß . Regulation CD8A ITGAL 15544853 1355256 The mRNA expression levels following the anti-CD3 and anti-CD3+SOM treatment for 30 min was greater on the CD8+ T cells , and the LFA-1 expression of the [CD8+] T cells with anti-CD+SOM treatment was *affected* more severely than that of the CD4+ T cells . Regulation CD8A ITGAL 24158516 2889569 Essential *role* of in [CD8+] T-cell accumulation and activation in adipose tissue . Regulation CD8A ITGB2 19483086 2107898 *regulates* [CD8+] T cell activation via T cell receptor mediated and LFA-1 mediated Erk1/2 signal pathways . Regulation CD8A ITGB2 20805505 2318288 Thus , PYK2 facilitates dependent [CD8] T-cell *responses* and promotes CD8 T-cell short lived effector fate , suggesting that PYK2 may be an interesting therapeutic target to suppress exacerbated CD8 T-cell responses . Regulation CD8A JAG1 10623816 658375 The [CD8] T cell *response* to soluble generally results in deletional tolerance following transient , costimulation dependent activation . Regulation CD8A JAG1 10903715 712978 We evaluated the ability of human monocytes and immature and mature DCs to induce [CD8+] effector *responses* to influenza virus from resting memory cells . Regulation CD8A JAG1 11390476 822537 Neither supplementation of freshly isolated dendritic cells nor use of cultured , Ag-pulsed dendritic cells could significantly boost [CD8] *responses* to whole-protein in poorly cross priming donors . Regulation CD8A JAG1 11390476 822539 It remains unknown whether cross priming ability translates into any clinical advantage in ability to induce [CD8+] T cell *responses* to foreign . Regulation CD8A JAG1 11937541 928101 A LAG-3Ig fusion protein has been used in mice as an adjuvant protein to induce antitumor responses and specific [CD8] and CD4 Th1 *responses* to nominal . Regulation CD8A JAG1 15843538 1398489 The [CD8] ( + ) T cell *response* to Moloney-murine leukemia virus ( M-MuLV ) -induced is almost entirely dominated by the exclusive expansion of lymphocytes that use preferential TCRVbeta chain rearrangements . Regulation CD8A JAG1 17579024 1763678 The role of CD4+ T cells in promoting [CD8+] T cell effector activity in *response* to transplant in vivo has not been reported . Regulation CD8A JAG1 21106849 2372089 Unexpectedly , in contrast to T ( reg ) cell depletion therapy with anti-CD4 , GITR stimulation induced very weak [CD8] T cell *responses* to melanocyte differentiation expressed by the tumor , and did not induce autoimmune vitiligo . Regulation CD8A JAG1 22234690 2579918 Twenty-seven patients who had undergone a reduced intensity allogeneic transplantation for acute myeloid leukemia were treated with monthly courses of AZA , and [CD8] ( + ) T-cell *responses* to candidate tumor and circulating Tregs were measured . Regulation CD8A MUC16 16272309 1479323 The immunological switch provided by Th-Th cooperation was sufficient to induce .1-specific CD4 and [CD8] T cell *responses* in MUC .1-transgenic mice , and protect them permanently from tumor growth . Regulation CD8A TCN1 10910289 713979 Here , we compared the capacity of in vitro generated normal liver immature DC and FL-treated donor liver DC to induce alloimmune CD4+ T helper (Th) 1/Th2 and [CD8+] *responses* , in vitro and in vivo . Regulation CD8A TCN1 12193722 981488 Multiple Chlamydia pneumoniae antigens prime [CD8+] *responses* that inhibit intracellular growth of this vacuolar pathogen . Regulation CD8A TCN1 14971031 1209300 Dendritic cells generated in the presence of GM-CSF plus IL-15 prime potent [CD8+] *responses* in vivo . Regulation CD8A TCN1 15557623 1340875 IL-12 p40 levels in serum and magnitudes of CD4+ Th1 and [CD8+] *responses* against Listeria antigen were significantly higher in AC-1 treated mice than in PBS treated mice . Regulation CD8A TCN1 15843575 1398526 Recently we reported that Cpn infected mice generate an MHC class I-restricted [CD8] ( + ) *response* against various Cpn Ags , and that CD8 ( + ) CTL to multiple epitopes inhibit Cpn growth in vitro . Regulation CD8A TCN1 16306600 1486446 Th-cytotoxic T-lymphocyte chimeric epitopes extended by Nepsilon-palmitoyl lysines induce herpes simplex virus type 1-specific effector [CD8+] *responses* and protect against ocular infection . Regulation CD8A TCN1 16308571 1486537 Here , we show that plasmid DNA vaccination with a cassette encoding antigen ( OVA ) and a second cassette encoding full-length CD40 ligand (CD40L) , a molecule expressed on activated CD4+ T lymphocytes and critical for T cell helper function , can elicit significant titers of antigen-specific immunoglobulins in serum and [CD8+] T cell *responses* in CD4-deficient mice . Regulation CD8A TCN1 17048270 1641841 Using an adoptive transfer system of OT-I cells expressing OVA ( 257-264 ) /Kb-specific TCR into Tyk2-/- mice followed by challenge with recombinant L. monocytogenes expressing OVA , we found that the defective Tyk2 signaling in the host environment was at least partially responsible for the impaired [CD8+] cell *responses* in Tyk2-/- mice following the infection . Regulation CD8A TCN1 17274112 1691879 Our data showed that CD4+ Th1 cells with acquired pMHC I by OVA pulsed DC ( DCOVA ) stimulation are capable of prolonging survival and reducing apoptosis formation of active CD8+ Tc1 cells in vitro , and promoting [CD8+] cell tumor localization and memory *responses* in vivo by 3-folds . Regulation CD8A TCN1 9550413 477788 Identification of Trypanosoma cruzi trans-sialidase family members as targets of protective [CD8+] *responses* . Regulation CD8A TLR7 21340621 2420418 Our goal was to determine the *effect* of stimulation on the priming and activation of diabetogenic [CD8] ( + ) T cells . Regulation CD8A TNF 11466378 839982 pfp ( -/- ) mice , was noted despite no significant differences in initial hepatic [CD8] ( + ) T cell IFN-gamma or *responses* or in activation of intrahepatic cytotoxic lymphocytes cells capable of killing AdCMV-lacZ infected fibroblast targets . Regulation CD8A TNF 15596816 1356616 *Role* of receptors in regulating [CD8] T-cell responses during acute lymphocytic choriomeningitis virus infection . Regulation CD8A TNF 15596816 1356618 To address these issues , we have investigated the *role* of I ( p55R ) and II ( p75R ) in regulating [CD8] T-cell responses to lymphocytic choriomeningitis virus ( LCMV ) with wild-type , p55R-deficient ( p55 ( -/- ) ) , p75R-deficient ( p75 ( -/- ) ) , and p55R- and p75R-deficient ( DKO ) mice . Regulation CD8A TNF 2161875 135842 did not *affect* the expression of LFA1 , CD2 , CD4 , and [CD8] , molecules that are associated with CTL-target interactions , on responder cells . Regulation CD8A TNF 23526821 2772444 A useful model for in vivo CD8 CTL in the absence of exogenous pathogens is the alloantigen-driven parent-into F1 model of acute graft-versus-host disease ( GVHD ) characterized by a strong *dependent* donor antihost [CD8] CTL T cell response . Regulation CD8A TNFSF10 17127445 1667941 However , a *role* of as a fine tuning regulator of the immune system , especially in the regulation of [CD8+] T cell activation and memory , has been also demonstrated . Regulation CD8A TNFSF10 21940678 2497481 The current study examined the *role* of in the pulmonary [CD8] T cell response to a clinically significant IAV [ A/PR/8/34 ( PR8 ; Regulation CD8B CEACAM6 23603913 2790050 These findings suggest that *plays* an important role in the regulation of [CD8+] T-cell responses against multiple myeloma ; Regulation CD8B FAS 11509617 848601 However , inhibition of perforin activity , the interaction , or both CTL mechanisms did not *affect* CD4 ( + ) and [CD8] ( + ) T cell mediated restriction of MTB growth . Regulation CD8B FAS 21297009 2420019 The decrease in the numbers of [CD8] ( + ) DCs required iNKT cells but was *independent* of perforin , , or IFN-? , as it was observed in mice deficient in each of these molecules . Regulation CD8B IFI27 17184540 1663801 Both the tenofovir treated and untreated macaques infected with SIVmac239Deltanef had antibody responses to SIV gp130 and antigens and SIV-specific [CD8+] T cell *responses* prior to SIVmac055 challenge , but only those animals receiving concurrent treatment with tenofovir resisted infection with SIVmac055 . Regulation CD8B IFI27 21326316 2453114 Our findings indicate a potential *role* for in the suppressive capacity of peptide induced regulatory [CD8] ( + ) Ti cells through effects on the expression of Foxp3 and the synthesis of TGFß . Regulation CD8B ITGAL 15544853 1355257 The mRNA expression levels following the anti-CD3 and anti-CD3+SOM treatment for 30 min was greater on the CD8+ T cells , and the LFA-1 expression of the [CD8+] T cells with anti-CD+SOM treatment was *affected* more severely than that of the CD4+ T cells . Regulation CD8B ITGB2 20805505 2318290 Thus , PYK2 facilitates dependent [CD8] T-cell *responses* and promotes CD8 T-cell short lived effector fate , suggesting that PYK2 may be an interesting therapeutic target to suppress exacerbated CD8 T-cell responses . Regulation CD8B JAG1 10903715 712979 We evaluated the ability of human monocytes and immature and mature DCs to induce [CD8+] effector *responses* to influenza virus from resting memory cells . Regulation CD8B JAG1 11390476 822538 Neither supplementation of freshly isolated dendritic cells nor use of cultured , Ag-pulsed dendritic cells could significantly boost [CD8] *responses* to whole-protein in poorly cross priming donors . Regulation CD8B JAG1 11390476 822540 It remains unknown whether cross priming ability translates into any clinical advantage in ability to induce [CD8+] T cell *responses* to foreign . Regulation CD8B JAG1 15843538 1398490 The [CD8] ( + ) T cell *response* to Moloney-murine leukemia virus ( M-MuLV ) -induced is almost entirely dominated by the exclusive expansion of lymphocytes that use preferential TCRVbeta chain rearrangements . Regulation CD8B JAG1 21106849 2372090 Unexpectedly , in contrast to T ( reg ) cell depletion therapy with anti-CD4 , GITR stimulation induced very weak [CD8] T cell *responses* to melanocyte differentiation expressed by the tumor , and did not induce autoimmune vitiligo . Regulation CD8B JAG1 22234690 2579919 Twenty-seven patients who had undergone a reduced intensity allogeneic transplantation for acute myeloid leukemia were treated with monthly courses of AZA , and [CD8] ( + ) T-cell *responses* to candidate tumor and circulating Tregs were measured . Regulation CD8B TCN1 10910289 713983 Here , we compared the capacity of in vitro generated normal liver immature DC and FL-treated donor liver DC to induce alloimmune CD4+ T helper (Th) 1/Th2 and [CD8+] *responses* , in vitro and in vivo . Regulation CD8B TCN1 15557623 1340877 IL-12 p40 levels in serum and magnitudes of CD4+ Th1 and [CD8+] *responses* against Listeria antigen were significantly higher in AC-1 treated mice than in PBS treated mice . Regulation CD8B TCN1 15843575 1398527 Recently we reported that Cpn infected mice generate an MHC class I-restricted [CD8] ( + ) *response* against various Cpn Ags , and that CD8 ( + ) CTL to multiple epitopes inhibit Cpn growth in vitro . Regulation CD8B TCN1 16306600 1486447 Th-cytotoxic T-lymphocyte chimeric epitopes extended by Nepsilon-palmitoyl lysines induce herpes simplex virus type 1-specific effector [CD8+] *responses* and protect against ocular infection . Regulation CD8B TCN1 17274112 1691880 Our data showed that CD4+ Th1 cells with acquired pMHC I by OVA pulsed DC ( DCOVA ) stimulation are capable of prolonging survival and reducing apoptosis formation of active CD8+ Tc1 cells in vitro , and promoting [CD8+] cell tumor localization and memory *responses* in vivo by 3-folds . Regulation CD8B TCN1 9550413 477789 Identification of Trypanosoma cruzi trans-sialidase family members as targets of protective [CD8+] *responses* . Regulation CD8B TLR7 21340621 2420419 Our goal was to determine the *effect* of stimulation on the priming and activation of diabetogenic [CD8] ( + ) T cells . Regulation CD8B TNF 11466378 839983 pfp ( -/- ) mice , was noted despite no significant differences in initial hepatic [CD8] ( + ) T cell IFN-gamma or *responses* or in activation of intrahepatic cytotoxic lymphocytes cells capable of killing AdCMV-lacZ infected fibroblast targets . Regulation CD8B TNF 23526821 2772445 A useful model for in vivo CD8 CTL in the absence of exogenous pathogens is the alloantigen-driven parent-into F1 model of acute graft-versus-host disease ( GVHD ) characterized by a strong dependent donor antihost [CD8] CTL T cell *response* . Regulation CD8B TNFSF10 17127445 1667942 However , a *role* of as a fine tuning regulator of the immune system , especially in the regulation of [CD8+] T cell activation and memory , has been also demonstrated . Regulation CDC123 SLC6A2 12598903 1064402 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Regulation CDC16 SLC6A2 12598903 1064403 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Regulation CDC16 TFPI2 9405394 469802 The direct interaction of PP5 with CDC16 and CDC27 , as well as its overlapping spindle localization in mitosis , suggests that may be *involved* in the regulation of the activity of the [anaphase promoting complex] . Regulation CDC20 ID1 18372912 1938169 The negative *effect* of on APC ( Cdh1 ) results in suppression of APC ( Cdh1 ) -induced Aurora A and [Cdc20] degradation , leading to failure in cytokinesis . Regulation CDC20 SLC6A2 12598903 1064404 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Regulation CDC20 STK39 18083840 1837557 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation CDC23 SLC6A2 12598903 1064405 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Regulation CDC23 TFPI2 9405394 469803 The direct interaction of PP5 with CDC16 and CDC27 , as well as its overlapping spindle localization in mitosis , suggests that may be *involved* in the regulation of the activity of the [anaphase promoting complex] . Regulation CDC25B NES 15003534 1217246 The nuclear exclusion of [CDC25B] is *controlled* by the binding of 14-3-3 to the of CDC25B , which was reported to be amino acids H28 to L40 in the N-terminal region of CDC25B . Regulation CDC25C CAPN8 9045698 416579 Together , these results emphasize the role of the other domains of CDC25 ( Mm ) in controlling the activity of the catalytic domain and support the *involvement* of calmodulin and in the in vivo regulation of the [CDC25] ( Mm ) activity . Regulation CDC26 SLC6A2 12598903 1064414 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Regulation CDC27 SLC6A2 12598903 1064406 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Regulation CDC27 TFPI2 9405394 469804 The direct interaction of PP5 with CDC16 and CDC27 , as well as its overlapping spindle localization in mitosis , suggests that may be *involved* in the regulation of the activity of the [anaphase promoting complex] . Regulation CDC34 SLC6A2 12598903 1064407 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Regulation CDC37 SLC6A2 12598903 1064408 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Regulation CDC37 TFPI2 18922470 1977216 We show that Cdc37 and associate in Hsp90 complexes in yeast and in human tumor cells , and that PP5/Ppt1 *regulates* phosphorylation of [Ser13-Cdc37] in vivo , directly affecting activation of protein kinase clients by Hsp90-Cdc37 . Regulation CDC40 SLC6A2 12598903 1064409 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Regulation CDC42 PLAU 12719789 1084091 Endogenous RhoA , but not Rac1 or [Cdc42] , was significantly activated in *response* to . Regulation CDC42 SLC6A2 12598903 1064410 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Regulation CDC45 SLC6A2 12598903 1064411 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Regulation CDC6 SLC6A2 12598903 1064412 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Regulation CDC7 SLC6A2 12598903 1064413 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Regulation CDC73 ALOX5 3152458 104199 This suggests that <5-lipoxygenase> *dependent* mediators and [PAF] are involved in allergic contact dermatitis and that these mediators play only a minor role in irritant dermatitis . Regulation CDC73 ALOX5 7488299 323019 This study has examined the *effects* of a new <5-lipoxygenase> inhibitor , 6-hydroxy-2- ( 4-sulfamoylbenzylamino ) -4,5,7-trimethylbenzothiazo le hydrochloride ( CAS 120164-49-0 , E6080 ) on the release of LTC4 , LTB4 and [PAF] by human eosinophils , Eosinophils stimulated by 1 mumol/l calcium ionophore A23187 for 15 min released 37.5 +/- 2.2 ng , 2.3 +/- 0.3 ng and 4.0 +/- 0.3 pmol per 10 ( 6 ) cells of immunoreactive LTC4 , LTB4 and PAF , respectively ( mean +/- SEM , n = 4 ) . Regulation CDC73 ARSA 8107285 246008 Next , synthesized PAF from washed platelets or washed leukocytes stimulated with collagen or ONO-11113 ( STA2 ; stable analogue of thromboxane A2 ) , and the inhibiting *effects* of on the [PAF] synthesis from collagen stimulated leukocytes were examined , using a radioimmunoassay kit for PAF . Regulation CDC73 EDN2 2051719 161770 The purpose of the present series of experiments has been to analyze the functional relations between the *effect* of on renal function and glomerular and mesangial cell contraction and the production and actions of [PAF] in kidney . Regulation CDC73 F2R 10395981 627772 The *effect* of a agonist peptide ( TRAP-6 ) on the release of nitric oxide ( NO ) and [platelet activating factor (PAF)] from resting and calcium-ionophore ( A23187 ) -activated rat peritoneal mast cells ( RPMC ) was studied using a platelet aggregation bioassay . Regulation CDC73 SLC6A2 12598903 1064401 The ability of separase to activate [Cdc14] is independent of its protease function but may *involve* promoting phosphorylation of the Cdc14 inhibitor . Regulation CDC73 TNF 1499148 193554 4. Furthermore , we investigated the priming *effect* of recombinant human , which is known to be one of the most important mediators in the development of ARDS , on [PAF] production induced by the calcium ionophore in neutrophils . Regulation CDC73 TNF 1846897 153385 We have further examined the *effects* of on arachidonic acid ( AA ) release , LTB4 production , and [platelet activating factor (PAF)] formation in PMN by prelabeling cells with either [ 3H ] AA or [ 3H ] lyso-PAF , priming with human rTNF-alpha , and then stimulating with the chemotactic peptide , FMLP . Regulation CDC73 TNF 3119758 80240 Synthesis of [PAF] in *response* to was also detected in rat polymorphonuclear neutrophils , but not in human tumor cells and dermal fibroblasts . Regulation CDC73 TNF 3261295 95996 About 30 % of [PAF] produced in *response* to either or IL-1 is released into the medium , whereas approximately 70 % remains cell associated . Regulation CDC73 TNF 3261295 96011 Experiments with labeled precursors show that [PAF] is synthesized de novo in *response* to . Regulation CDC73 TNF 3261295 96022 This suggests that [PAF] is synthesized by the same pathway in *response* to or IL-1 . Regulation CDC73 TNF 8488366 219197 In contrast to its effect on the AA turnover , did not *affect* the phospholipase C-stimulated production of platelet activating factor ( [PAF-acether] ) . Regulation CDC73 TNF 9187959 437080 GM-CSF production by EC was also stimulated by the combined effects of PAF and , but [PAF] alone did not *affect* GM-CSF production . Regulation CDCA2 HSD11B2 8969942 402769 These results show that both 3 alpha,5B-THP and [CDCA] are hypertensinogenic in the rat and that the inhibition of either <11 beta-HSD2> or 11 beta-HSD1 activity by endogenous progesterone metabolites and CDCA may be *involved* in the pathology of hypertension . Regulation CDCA2 IL1B 16729332 1565759 Human primary hepatocytes and HepG2 cells were used as models to study [chenodeoxycholic acid (CDCA)] and *regulation* of human CYP7A1 gene expression via real-time polymerase chain reaction , reporter assays , co-immunoprecipitation and chromatin immunocipitation ( ChIP ) assays . Regulation CDCA3 HSD11B2 8969942 402770 These results show that both 3 alpha,5B-THP and [CDCA] are hypertensinogenic in the rat and that the inhibition of either 11 beta-HSD2 or <11 beta-HSD1> activity by endogenous progesterone metabolites and CDCA may be *involved* in the pathology of hypertension . Regulation CDCA3 IL1B 16729332 1565760 Human primary hepatocytes and HepG2 cells were used as models to study [chenodeoxycholic acid (CDCA)] and *regulation* of human CYP7A1 gene expression via real-time polymerase chain reaction , reporter assays , co-immunoprecipitation and chromatin immunocipitation ( ChIP ) assays . Regulation CDCA4 HSD11B2 8969942 402771 These results show that both 3 alpha,5B-THP and [CDCA] are hypertensinogenic in the rat and that the inhibition of either <11 beta-HSD2> or 11 beta-HSD1 activity by endogenous progesterone metabolites and CDCA may be *involved* in the pathology of hypertension . Regulation CDCA4 IL1B 16729332 1565761 Human primary hepatocytes and HepG2 cells were used as models to study [chenodeoxycholic acid (CDCA)] and *regulation* of human CYP7A1 gene expression via real-time polymerase chain reaction , reporter assays , co-immunoprecipitation and chromatin immunocipitation ( ChIP ) assays . Regulation CDCA5 CAPN8 17416967 1722885 Recent evidence supports A beta induction of a *dependent* cleavage of the cyclin dependent kinase 5 (cdk5) regulatory protein [p35] that contributes to tau hyperphosphorylation and neuronal death . Regulation CDCA5 HSD11B2 8969942 402772 These results show that both 3 alpha,5B-THP and [CDCA] are hypertensinogenic in the rat and that the inhibition of either 11 beta-HSD2 or <11 beta-HSD1> activity by endogenous progesterone metabolites and CDCA may be *involved* in the pathology of hypertension . Regulation CDCA5 IL1B 16729332 1565762 Human primary hepatocytes and HepG2 cells were used as models to study [chenodeoxycholic acid (CDCA)] and *regulation* of human CYP7A1 gene expression via real-time polymerase chain reaction , reporter assays , co-immunoprecipitation and chromatin immunocipitation ( ChIP ) assays . Regulation CDCA7 HSD11B2 8969942 402773 These results show that both 3 alpha,5B-THP and [CDCA] are hypertensinogenic in the rat and that the inhibition of either <11 beta-HSD2> or 11 beta-HSD1 activity by endogenous progesterone metabolites and CDCA may be *involved* in the pathology of hypertension . Regulation CDCA7 IL1B 16729332 1565763 Human primary hepatocytes and HepG2 cells were used as models to study [chenodeoxycholic acid (CDCA)] and *regulation* of human CYP7A1 gene expression via real-time polymerase chain reaction , reporter assays , co-immunoprecipitation and chromatin immunocipitation ( ChIP ) assays . Regulation CDCA8 HSD11B2 8969942 402774 These results show that both 3 alpha,5B-THP and [CDCA] are hypertensinogenic in the rat and that the inhibition of either 11 beta-HSD2 or <11 beta-HSD1> activity by endogenous progesterone metabolites and CDCA may be *involved* in the pathology of hypertension . Regulation CDCA8 IL1B 16729332 1565764 Human primary hepatocytes and HepG2 cells were used as models to study [chenodeoxycholic acid (CDCA)] and *regulation* of human CYP7A1 gene expression via real-time polymerase chain reaction , reporter assays , co-immunoprecipitation and chromatin immunocipitation ( ChIP ) assays . Regulation CDH1 CAPN8 12393869 1035861 The *role* of in the proteolytic cleavage of [E-cadherin] in prostate and mammary epithelial cells . Regulation CDH1 EPHB2 22328534 2642866 Taken together , data indicated that the expression of GSK-3a , ß-catenin and [E-cadherin] could be negatively *regulated* by Tß4 induced phosphorylation . Regulation CDH1 HBEGF 17875687 1796185 Our data here clearly indicated the distinct *role* of in the regulation of [E-cadherin] expression and the epithelial-mesenchymal transition . Regulation CDH1 HBEGF 23305395 2738066 We evaluated the *effect* of on the expression of integrins , [E-cadherin/ß-catenin] , and integrin a5ß1 dependent cell-ECM interactions . Regulation CDH1 MMP7 19893044 2171467 Thus , to assess *effects* on [CD103-E-cadherin] interactions in lung injury , wild-type , CD103 ( -/- ) , and Mmp7 ( -/- ) mice , in which E-cadherin is n't cleaved in the lung , were treated with bleomycin or bleomycin with nFMLP to reverse the defect in acute neutrophil influx seen in Mmp7 ( -/- ) mice . Regulation CDH1 MSX1 22100262 2517381 Loss of expression correlates with altered uterine luminal epithelial cell polarity and *affects* [E-cadherin/ß-catenin] complex formation through the control of Wnt5a expression . Regulation CDH1 NEDD9 21765937 2456700 and BCAR1 negatively *regulate* [E-cadherin] membrane localization , and promote E-cadherin degradation . Regulation CDH1 PCDH19 22193776 2543905 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH1 PCDH8 22193776 2543910 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH1 PLAU 10457348 639295 These results indicate that is an enzyme that may be important in the degradation of extracellular matrix during development and that specific [E-cadherin] interactions and hormones can *regulate* its activity . Regulation CDH1 TF 17912456 1803859 differentially *regulated* [E-cadherin] and beta-catenin in these cells . Regulation CDH1 TNF 10616200 575826 The *effect* of on [E-cadherin] expression was maximal after stimulation for 48 hours and also induced modest reductions in beta-catenin expression . Regulation CDH1 WNT7A 21874048 2579379 Moreover , we found that [E-cadherin] expression in cancer cells may be positively *regulated* by , whose expression is negatively regulated by mesenchymal-specific DNA hypermethylation or ZEB1 in mesenchymal-like OSCC cells . Regulation CDH10 PCDH19 22193776 2543916 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH10 PCDH8 22193776 2543921 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH11 PCDH19 22193776 2543927 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH11 PCDH8 22193776 2543932 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH12 PCDH19 22193776 2543938 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH12 PCDH8 22193776 2543943 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH13 PCDH19 22193776 2543949 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH13 PCDH8 22193776 2543954 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH13 TNF 12871932 1142278 Moreover , [p105] degradation in *response* to is prevented in GSK-3 beta-/- fibroblasts and by a Ser to Ala point mutation on p105 at positions 903 or 907 . Regulation CDH15 PCDH19 22193776 2543960 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH15 PCDH8 22193776 2543965 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH16 PCDH19 22193776 2543971 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH16 PCDH8 22193776 2543976 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH17 PCDH19 22193776 2543982 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH17 PCDH8 22193776 2543987 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH18 PCDH19 22193776 2543993 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH18 PCDH8 22193776 2543998 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH19 PCDH19 22193776 2544004 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH19 PCDH8 22193776 2544009 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH2 CTGF 20117462 2202366 Rac1 induced *regulates* connexin 43 and [N-cadherin] expression in atrial fibrillation . Regulation CDH2 MMP7 20139113 2265136 This study demonstrates that is *involved* in the cleavage of [N-cadherin] and modulates VSMC apoptosis , and may therefore contribute to plaque development and rupture . Regulation CDH2 PCDH19 22193776 2544015 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH2 PCDH8 22193776 2544020 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH2 S1PR3 15371328 1304103 *regulation* of [N-cadherin] mediates vascular stabilization . Regulation CDH2 TGM2 23290789 2764008 The *involvement* of in [N-cadherin] expression was also confirmed in an in vivo lung cancer orthotopic model by injection of A549 ( WT ) and A549 ( shTG2 ) cells into SCID mice . Regulation CDH20 PCDH19 22193776 2544026 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH20 PCDH8 22193776 2544031 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH22 PCDH19 22193776 2543861 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH22 PCDH8 22193776 2543866 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH23 PCDH19 22193776 2543872 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH23 PCDH8 22193776 2543877 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH24 PCDH19 22193776 2543883 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH24 PCDH8 22193776 2543888 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH26 PCDH19 22193776 2543894 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH26 PCDH8 22193776 2543899 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH3 PCDH19 22193776 2544037 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH3 PCDH8 22193776 2544042 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH4 PCDH19 22193776 2544048 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH4 PCDH8 22193776 2544053 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH5 MMP28 15530852 1332831 Our data suggest that TIMP-1 inhibits HDMVEC migration through *dependent* stimulation of [VE-cadherin] and MMP independent stimulation of PTEN with subsequent dephosphorylation of FAK and cytoskeletal remodeling . Regulation CDH5 MMP7 15530852 1332846 Our data suggest that TIMP-1 inhibits HDMVEC migration through *dependent* stimulation of [VE-cadherin] and MMP independent stimulation of PTEN with subsequent dephosphorylation of FAK and cytoskeletal remodeling . Regulation CDH5 PCDH19 22193776 2544059 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH5 PCDH8 22193776 2544064 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH5 TNF 12010652 941258 We investigated whether *regulates* the synthesis of [VE-cadherin] on the transcriptional level . Regulation CDH5 TNF 12010652 941260 Our results indicate that *affects* [VE-cadherin] gene expression on the transcriptional level , inducing a downregulation of the VE-cadherin expression . Regulation CDH5 TNF 12095140 960558 The purpose of our study was to determine the *effect* of on [VE-cadherin] cell-surface expression and to identify the signaling pathways involved in TNF induced changes in cadherin expression . Regulation CDH5 TNF 12095140 960587 Inhibition of p38 but not ERK MAPK significantly reduced the *effect* of on endothelial permeability and cell-surface [VE cadherin] expression . Regulation CDH6 PCDH19 22193776 2544070 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH6 PCDH8 22193776 2544075 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH7 PCDH19 22193776 2544081 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH7 PCDH8 22193776 2544086 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH8 PCDH19 22193776 2544092 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH8 PCDH8 22193776 2544097 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH9 PCDH19 22193776 2544103 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDH9 PCDH8 22193776 2544108 Xenopus paraxial ( PAPC ) *regulates* [cadherin] mediated cell adhesion and promotes the planar cell polarity (PCP) pathway . Regulation CDK1 CCND1 24333727 2910833 MiR-302 directly targeted , but indirectly *regulated* [CDK1] gene expression . Regulation CDK1 MIP 17098733 1676151 *regulates* the expression of B-Myb and the induction of cyclin A , cyclin B , and [CDK1] . Regulation CDK1 RARB 21868513 2473736 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Regulation CDK1 TNF 16520149 1531140 The response of tumors to MET-stress depends on their mutational status , however , it always involves inhibition of [CDK1] and in most cases the upregulation of p21 , p27 , GADDs and 14-3-3sigma in *response* to upregulation of TGF-beta , IRF-1 , , Rb and/or MDA-7 and the downregulation of PI3K , RAS and NF-kappaB . Regulation CDK1 TNF 8262134 239140 However , as cells approached senescence , their ability to induce [CDC2] and CDK2 , as well as stimulate DNA synthesis in *response* to , progressively declined , with minimal to absent induction in senescent cells . Regulation CDK10 RARB 21868513 2473738 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Regulation CDK12 RARB 21868513 2473749 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Regulation CDK13 RARB 21868513 2473737 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Regulation CDK14 RARB 21868513 2473753 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Regulation CDK15 RARB 21868513 2473735 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Regulation CDK16 RARB 21868513 2473750 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Regulation CDK17 RARB 21868513 2473751 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Regulation CDK18 RARB 21868513 2473752 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Regulation CDK19 RARB 21868513 2473747 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Regulation CDK19 TF 2440461 74281 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation CDK19 TNF 14550746 1152762 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation CDK19 TNF 17307735 1719124 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation CDK19 TNF 17988550 1821542 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation CDK2 CCND1 12401786 1025522 Our data also demonstrate that ectopic overexpression of either cyclin is sufficient to induce mitogen independent growth in human T98G and Rat-1 cells , although the *effects* of require downstream activation of cyclin [E-CDK2] activity . Regulation CDK2 EPHB2 11304535 819978 Here , we show that also *affects* [CDK2-cyclin] E activation by regulating the subcellular localization of CDK2 . Regulation CDK2 EPHB2 15547725 1338351 Our data indicate that activated *plays* an important role in cyclin D1 and [Cdk-2] expression and phosphorylation of pRB at Ser780 and Ser795 in liver cancer cells . Regulation CDK2 EPHB2 15917995 1413223 We have demonstrated that ( MAPK ) signaling was *involved* in the induction of both p15(INK4b)and p16(INK4a) [CDK] inhibitors and growth inhibition of hepatoma cell HepG2 triggered by the tumor promoter tetradecanoyl phorbol acetate ( TPA ) . Regulation CDK2 EPHB2 17893107 1823880 The map kinase *regulates* renal activity of [cyclin dependent kinase 2] in experimental glomerulonephritis . Regulation CDK2 FOXO1 23995784 2948770 In addition to regulation by direct promoter binding of EWS-FLI1 , its subcellular localization and activity is *regulated* by [cyclin dependent kinase 2-] and AKT mediated phosphorylation downstream of EWS-FLI1 . Regulation CDK2 IFI27 14517080 1147266 Remarkably , degradation of ( Kip1 ) , a negative *regulator* of both Cdk4/cyclin D and [Cdk2/cyclin] E complexes , is significantly diminished in T cells treated with HCV core upon mitogenic stimulation . Regulation CDK2 IFI27 17096381 1693161 ( Kip1 ) , an important *regulator* of [Cdk2] activity and G1/S transition , is tightly regulated in a cell-type and condition-specific manner to integrate mitogenic and differentiation signals governing cell cycle progression . Regulation CDK2 IFI27 17254967 1691043 phosphorylation by Src *regulates* inhibition of cyclin [E-Cdk2] . Regulation CDK2 IFI27 21033368 2338891 When the programme decreases the bioenergetics level below certain value the cyclin [E-Cdk2] becomes the *target* for . Regulation CDK2 IFI27 22223646 2559098 In mammalian cells [Cdk2] activity during the G ( 1 ) -S transition is mainly *controlled* by ( KIP1 ) . Regulation CDK2 IFI27 22584582 2614296 During the G ( 1 ) -S transition , the activity of Cdk2 is *regulated* by its association with ( KIP1 ) , which in rodent fibroblasts undergoes phosphorylation mainly at serine 10 , threonine 187 , and C-terminal threonine 197 by KIS , [Cdk2] , and Pim or ROCK , respectively . Regulation CDK2 IFI27 23071750 2690012 *regulates* the activity of [Cdk] complexes which are the principal governors of phase transitions during cell division . Regulation CDK2 RARB 21868513 2473739 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Regulation CDK2 TNF 8262134 239141 However , as cells approached senescence , their ability to induce CDC2 and [CDK2] , as well as stimulate DNA synthesis in *response* to , progressively declined , with minimal to absent induction in senescent cells . Regulation CDK20 RARB 21868513 2473748 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Regulation CDK3 RARB 21868513 2473740 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Regulation CDK4 CCND1 14710852 1181385 Over-expression of *regulates* [Cdk4] protein synthesis . Regulation CDK4 EPHB2 22214150 2519152 It was found that and JNK were *involved* in silica induced cyclin D1 and [CDK4] overexpression and the decreased expression of E2F-4 . Regulation CDK4 RARB 21868513 2473741 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Regulation CDK5 CAPN8 19830249 2149098 The kinase is typically activated by p25 , derived from p35 by calpain mediated cleavage , but inhibition of does not *affect* cell death or the activation of [Cdk5] . Regulation CDK5 CAPN8 23616539 2774859 We further show that neuronal nitric oxide synthase is regulated by cholinergic excess through activation of skeletal muscle and its *effect* on [Cdk5] and CaMKII , leading to direct modulation of presynaptic function . Regulation CDK5 EPHB2 17117479 1677409 In addition , we provide evidence that the signaling *regulates* [Cyclin dependent kinase 5 (Cdk5)] activity and stability of tumor suppressor p53 . Regulation CDK5 EPHB2 24498195 2913868 MAP kinase activation in spinal cord *regulates* phosphorylation of [Cdk5] at serine 159 and contributes to peripheral inflammation induced pain/hypersensitivity . Regulation CDK5 EPHB2 24498195 2913872 All these findings suggested that [p-Cdk5] ( S159 ) *regulated* by pathway activity may be a critical mechanism involved in the activation of Cdk5 in nociceptive spinal neurons contributes to peripheral inflammatory pain hypersensitivity . Regulation CDK5 IFI27 20189989 2243003 [Cdk5] nuclear localization is *dependent* in nerve cells : implications for cell cycle suppression and caspase-3 activation . Regulation CDK5 NES 17036052 1634549 When the underlying link between nestin and Cdk5 was analyzed , we observed that serves as a scaffold for Cdk5 , with binding restricted to a specific region following the alpha-helical domain of nestin , and that the presence and organization of nestin *regulated* the sequestration and activity of [Cdk5] , as well as the ubiquitylation and turnover of its regulator , p35 . Regulation CDK5 RARB 21868513 2473742 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Regulation CDK5 TNF 19049962 2023753 *regulates* [cyclin dependent kinase 5] activity during pain signaling through transcriptional activation of p35 . Regulation CDK5 TNF 19049962 2023772 These findings suggest that mediated *regulation* of [Cdk5] activity plays an important role in inflammation induced pain signaling . Regulation CDK5R1 CAPN8 23415811 2764696 Inhibition of *regulated* [p35/cdk5] plays a central role in sildenafil induced protection against chemical hypoxia produced by malonate . Regulation CDK6 CCND1 19575018 2129210 This *effect* of requires its transcription repression domain but is independent of cyclin dependent kinases CDK4 and [CDK6] . Regulation CDK6 RARB 21868513 2473743 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Regulation CDK7 RARB 21868513 2473744 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Regulation CDK8 RARB 21868513 2473745 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Regulation CDK8 TF 2440461 74279 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation CDK8 TNF 14550746 1152760 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation CDK8 TNF 17307735 1719122 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation CDK8 TNF 17988550 1821540 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation CDK9 RARB 21868513 2473746 HDACi inhibited cell cycle progression , and reversed promoter methylation and silencing of three tumor suppressor genes : and the cell cycle *regulating* [cyclin dependent kinase] inhibitors p16 and p21 . Regulation CDK9 TNF 15528190 1360048 did not *regulate* expression or localization of [CDK9] or its regulatory partner Cyclin T . Regulation CDK9 TNF 9528954 496218 The treatment with the antioxidants 20 mM N-acetyl-L-cysteine (NAC) and 10 microM pyrrolidine dithiocarbamate ( PDTC ) inhibited the *dependent* activation of p65-p50 [heterodimer] but not the p50-p50 homodimer , indicating that generation of oxidants is required for the activation of the heterodimer NF-kappaB . Regulation CDK9 TP63 9614940 509536 In order to elucidate the *role* of in the [heterodimer] , chimeric HIV-1/FIV RT heterodimers were constructed and characterized . Regulation CDKN1A ARSA 20404564 2307411 Furthermore , COX-1 siRNA attenuated the *effects* of combined and FK228 on the levels of [p21] expression and the amount of growth inhibition . Regulation CDKN1A CCND1 10474686 642363 In addition , the in vitro *effect* of on [p21] gene expression in MCF7 breast cancer cells was evaluated . Regulation CDKN1A CCND1 18006776 1827351 PPARgamma is overexpressed in ACHN cells and barely detectable in 786-0 cells , and treatment with DIM-C-pPhtBu induces proteasome dependent degradation of and variable *effects* on [p21] and p27 expression in both cell lines . Regulation CDKN1A CCND1 19306413 2056200 High concentrations of soil extracts decreased and increased [p21] *response* , indicating cell cycle arrest . Regulation CDKN1A CCND1 20801098 2324495 inhibits p300 dependent RUNX3 acetylation and negatively *regulates* cyclin dependent kinase (cdk) inhibitor [p21] expression . Regulation CDKN1A EPHB2 10962574 727224 PD098059 , a specific inhibitor of MEK , disminishes TGF-beta1 induced p21Cip1 levels in PDV but not in MCA3D cells , suggesting an *involvement* of in up-regulation of [p21Cip1] by TGF-beta1 in PDV cells . Regulation CDKN1A EPHB2 12381673 997377 Extracellular zinc stimulates *dependent* activation of [p21] ( Cip/WAF1 ) and inhibits proliferation of colorectal cancer cells . Regulation CDKN1A EPHB2 15665589 1350436 However , not all the cells appeared to respond to pathway *dependent* [p21Cip/WAF1] induction . Regulation CDKN1A EPHB2 17941827 1849420 Heregulin beta1 promotes breast cancer cell proliferation through *dependent* induction of cyclin D1 and [p21Cip1] . Regulation CDKN1A EPHB2 18272192 1903625 Inhibition of the phosphorylation *plays* a role in terbinafine induced [p21] up-regulation and DNA synthesis inhibition in human vascular endothelial cells . Regulation CDKN1A EPHB2 18272192 1903626 Taken together , these data suggest that the decrease of activity *plays* a role in the TB-induced up-regulation of [p21] in HUVEC . Regulation CDKN1A EPHB2 18949380 1978837 Overall , the TsA activated ERK pathway plays an important role in cell cycle arrest and apoptosis through the *dependent* induction of [p21] in Ras related human cancer cells . Regulation CDKN1A FOXO1 24769335 2939542 CAR mediated repression of transcriptional activity *regulates* the cell cycle inhibitor [p21] in mouse livers . Regulation CDKN1A ID1 22698403 2615693 *Regulation* of [p21] by and ID3 is a central mechanism preventing the accumulation of excess DNA damage and subsequent functional exhaustion of CC-ICs . Regulation CDKN1A MAP2K6 10511312 651244 In contrast , FGF-2 regulation of [p21] is largely *independent* of and Ras . Regulation CDKN1A MAP2K6 17317670 1719611 We conclude that CDA1 induces p53- and MAPK *dependent* expression of [p21] by acting through the p53 responsive element in the p21 promoter and that this contributes to its antiproliferative activity . Regulation CDKN1A RARB 9715277 527808 The favorable effect of high-level RAR beta expression on prognosis in primary tumor tissue may occur through *effects* on [p21] expression and consequent G0/G1 cell cycle arrest . Regulation CDKN1A TFPI2 9575175 502609 Employing a stable cell line derived from p53-deficient human fibroblast that contains tetracycline regulated transactivator and operator plasmids to control the expression of wild-type p53 ( TR9-7 cells ) , we then show that the induction of [p21] ( WAF1/Cip1 ) , which occurs in *response* to the inhibition of expression , requires the p53 protein . Regulation CDKN1A TNF 12189181 979958 potentiated the cadmium induced accumulation of p53 but did not *affect* expression levels of Bax , Mdm2 and [p21] ( WAF/CIP ) . Regulation CDKN1A TP63 12374749 996673 Over expression of wild-type , but not deletion mutant , SSRP1 remarkably enhanced *dependent* luciferase activity , G1 arrest , apoptosis and expression of endogenous PIG3 , [p21] ( Waf1/cip1 ) and MDM2 in human p53-deficient lung carcinoma H1299 cells and mouse embryonic fibroblasts . Regulation CDKN1A TP63 15965232 1446101 These results suggest that p300 regulates *dependent* transcription of [p21] . Regulation CDKN1A TP63 21480565 2361629 As p21 , a transcriptional target of the p53 family , is necessary for maintaining G2/M arrest , we analyzed the *roles* of p53 and in modulating IGF1 stimulated [p21] expression . Regulation CDKN1B CCND1 16924241 1692242 Mutant B-RAF signaling and *regulate* Cks1/S-phase kinase associated protein 2-mediated degradation of [p27Kip1] in human melanoma cells . Regulation CDKN1B EPHB2 15930121 1433868 phosphorylates p66shcA on Ser36 and subsequently *regulates* [p27kip1] expression via the Akt-FOXO3a pathway : implication of p27kip1 in cell response to oxidative stress . Regulation CDKN1B EPHB2 17314399 1711563 Mechanistic analysis showed that the *effect* on [p27kip1] is mediated by Skp2 and is secondary to its effect on cyclin D1 . Regulation CDKN1B FOXO1 11994454 939030 The forkhead transcription factor *regulates* transcription of [p27Kip1] and Bim in response to IL-2 . Regulation CDKN1B FOXO1 12891709 1117761 To understand mechanisms by which IGF-I signals the downregulation of p27Kip1 in rat skeletal satellite cells , the *role* of Forkhead transcription factor in transcriptional activity of [p27Kip1] was examined . Regulation CDKN1B FOXO1 18787071 1986169 Age dependent *regulation* of [p27Kip1] expression via a conserved binding motif in rat muscle precursor cells . Regulation CDKN1B MAP2K6 14504289 1164780 MAPKs were not directly associated with p27Kip1 phosphorylation at Thr198 , but the p90 ribosomal protein S6 kinases (RSKs) could bind to and directly phosphorylate [p27Kip1] at Thr198 in a *dependent* manner . Regulation CDKN1C CISH 11468278 840885 Distant *regulate* imprinted expression of the mouse p57( Kip2) ( [Cdkn1c] ) gene : implications for the human disorder , Beckwith--Wiedemann syndrome . Regulation CDKN1C CISH 22740650 2676163 MyoD *regulates* [p57kip2] expression by interacting with a distant and modifying a higher order chromatin structure . Regulation CDKN1C COPS2 23187808 2707771 CDK inhibitor [p57 (Kip2)] is negatively *regulated* by 6 . Regulation CDKN1C COPS3 23187808 2707768 CDK inhibitor [p57 (Kip2)] is negatively *regulated* by 6 . Regulation CDKN1C COPS4 23187808 2707766 CDK inhibitor [p57 (Kip2)] is negatively *regulated* by 6 . Regulation CDKN1C COPS5 23187808 2707769 CDK inhibitor [p57 (Kip2)] is negatively *regulated* by 6 . Regulation CDKN1C COPS6 23187808 2707767 CDK inhibitor [p57 (Kip2)] is negatively *regulated* by 6 . Regulation CDKN1C COPS8 23187808 2707770 CDK inhibitor [p57 (Kip2)] is negatively *regulated* by 6 . Regulation CDKN1C CXCL12 22541097 2590340 The *effect* of on [p57kip2] expression in bone marrow mononuclear cell ( BMMNC ) from MDS or normal controls was investigated in vitro , and difference between them was compared . Regulation CDKN1C CXCL12 22541097 2590343 Furthermore , SDF-1 induced [p57kip2] expression in BMMNC , and the decreasing *response* of BMMNC to may contribute to the low expression of p57kip2 in MDS patients . Regulation CDKN1C CXCL12 22889515 2642368 We also searched the *role* of signal in [p57kip2] expression in vitro . Regulation CDKN1C E2F1 20106982 2226560 [CDKN1C] negatively regulates RNA polymerase II C-terminal domain phosphorylation in an *dependent* manner . Regulation CDKN1C HES1 22705236 2633858 [CDKN1C/P57] is *regulated* by the Notch target gene and induces senescence in human hepatocellular carcinoma . Regulation CDKN1C HES1 25005473 2948363 Antagonistic *regulation* of [p57kip2] by downstream of Notch signaling and muscle regulatory factors regulates skeletal muscle growth arrest . Regulation CDKN1C HES2 25005473 2948358 Antagonistic *regulation* of [p57kip2] by downstream of Notch signaling and muscle regulatory factors regulates skeletal muscle growth arrest . Regulation CDKN1C HES3 25005473 2948362 Antagonistic *regulation* of [p57kip2] by downstream of Notch signaling and muscle regulatory factors regulates skeletal muscle growth arrest . Regulation CDKN1C HES4 25005473 2948361 Antagonistic *regulation* of [p57kip2] by downstream of Notch signaling and muscle regulatory factors regulates skeletal muscle growth arrest . Regulation CDKN1C HES5 25005473 2948360 Antagonistic *regulation* of [p57kip2] by downstream of Notch signaling and muscle regulatory factors regulates skeletal muscle growth arrest . Regulation CDKN1C HES6 25005473 2948359 Antagonistic *regulation* of [p57kip2] by downstream of Notch signaling and muscle regulatory factors regulates skeletal muscle growth arrest . Regulation CDKN1C HES7 25005473 2948357 Antagonistic *regulation* of [p57kip2] by downstream of Notch signaling and muscle regulatory factors regulates skeletal muscle growth arrest . Regulation CDKN1C MIR221 21461636 2438522 post-transcriptional *regulation* of P27KIP1 and [P57KIP2] is crucial for high-glucose- and AGE mediated vascular cell damage . Regulation CDKN1C MIR221 21461636 2438532 We provide evidence that high-glucose- and AGE induced inhibition of vascular cell proliferation is controlled by post-transcriptional *regulation* of P27KIP1 and [P57KIP2] . Regulation CDKN1C MIR221 22126772 2514793 To investigate the regulatory *effect* of on [CDKN1C/p57] expression in colon carcinoma cells in vitro . Regulation CDKN1C MIR222 21461636 2438523 post-transcriptional *regulation* of P27KIP1 and [P57KIP2] is crucial for high-glucose- and AGE mediated vascular cell damage . Regulation CDKN1C MIR222 21461636 2438533 We provide evidence that high-glucose- and AGE induced inhibition of vascular cell proliferation is controlled by post-transcriptional *regulation* of P27KIP1 and [P57KIP2] . Regulation CDKN1C MYLIP 20461750 2257627 and miR-222 negatively *regulate* expression of CDKN1B ( p27 ) and [CDKN1C] ( p57 ) , two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas . Regulation CDKN1C MYLIP 21278784 2398205 To investigate the regulatory *effect* of on [CDKN1C/p57] expression in colorectal carcinoma ( CRC ) . Regulation CDKN1C MYLIP 24308935 2877785 By siRNA technology , we also demonstrated that SOD-2 is the antioxidant enzyme involved in the control of posttranscriptional [p57(Kip2)] *regulation* . Regulation CDKN1C NAP1L2 21333655 2404018 *controls* the expression of its target genes , such as the cell cycle regulator [Cdkn1c] , at least in part via an effect on histone acetylation . Regulation CDKN1C NOTCH1 16033893 1436236 Here , we report that , in zebrafish , expression of the Cdki gene [cyclin dependent kinase inhibitor 1c] ( cdkn1c ) , a p57 homolog , is negatively *regulated* by signaling and that Cdkn1c function is required for neural plate cells to stop dividing and differentiate as neurons on schedule , even in the absence of Notch signaling activity . Regulation CDKN1C NOTCH2 16033893 1436237 Here , we report that , in zebrafish , expression of the Cdki gene [cyclin dependent kinase inhibitor 1c] ( cdkn1c ) , a p57 homolog , is negatively *regulated* by signaling and that Cdkn1c function is required for neural plate cells to stop dividing and differentiate as neurons on schedule , even in the absence of Notch signaling activity . Regulation CDKN1C NOTCH3 16033893 1436238 Here , we report that , in zebrafish , expression of the Cdki gene [cyclin dependent kinase inhibitor 1c] ( cdkn1c ) , a p57 homolog , is negatively *regulated* by signaling and that Cdkn1c function is required for neural plate cells to stop dividing and differentiate as neurons on schedule , even in the absence of Notch signaling activity . Regulation CDKN1C NOTCH4 16033893 1436239 Here , we report that , in zebrafish , expression of the Cdki gene [cyclin dependent kinase inhibitor 1c] ( cdkn1c ) , a p57 homolog , is negatively *regulated* by signaling and that Cdkn1c function is required for neural plate cells to stop dividing and differentiate as neurons on schedule , even in the absence of Notch signaling activity . Regulation CDKN1C PAK4 23873832 2839272 *regulates* the [cyclin dependent kinase inhibitor p57] ( kip2 ) in human breast cancer . Regulation CDKN1C PCNA 7729684 302226 [p57KIP2] is a potent , tight binding inhibitor of several G1 cyclin/Cdk complexes , and its binding is *dependent* . Regulation CDKN1C RENBP 21461636 2438534 We provide evidence that high-glucose- and induced inhibition of vascular cell proliferation is *controlled* by MIR221/MIR222-driven post-transcriptional regulation of P27KIP1 and [P57KIP2] . Regulation CDKN1C SKP2 12925736 1135310 Mutation of the threonine residue ( Thr-310 ) of human p57Kip2 that is conserved between the COOH-terminal QT domains of p57Kip2 and p27Kip1 prevented the *effect* of on the stability of [p57Kip2] , suggesting that phosphorylation at this site is required for SCFSkp2 mediated ubiquitylation . Regulation CDKN1C SMARCB1 19221586 2039678 We used an inducible expression system to show that the imprinted cell cycle inhibitor [CDKN1C] is a downstream *target* for and is transcriptionally activated by increased histone H3 and H4 acetylation at the promoter . Regulation CDKN1C USO1 23470527 2750371 In fact , *dependent* induction of [p57(Kip2)] expression accounted for inhibitory effects on the actin cytoskeleton dynamics and thereby cancer cell motility . Regulation CDKN2A ARSA 19144277 2006876 The finding was associated to increased levels of some CDKIs , namely p27 ( Kip1 ) and p21 ( Cip1 ) , whereas did not *affected* [p16(Ink4A)] level at any of the concentrations employed . Regulation CDKN2A EPHB2 15917995 1413224 We have demonstrated that ( MAPK ) signaling was *involved* in the induction of both p15(INK4b)and [p16(INK4a)] CDK inhibitors and growth inhibition of hepatoma cell HepG2 triggered by the tumor promoter tetradecanoyl phorbol acetate ( TPA ) . Regulation CDKN2A EPHB2 21923753 2539129 We show that UVR induced signalling , mediated by BRAF , *regulates* p16 ( [CDKN2A] ) expression at the transcriptional , and possibly translational level . Regulation CDKN2A EPHB2 24177224 2868307 Previously , it was shown that HGF treatment downregulated Id1 and upregulated [p16(INK4a)] in an *dependent* manner , leading to the inhibition of cellular proliferation . Regulation CDKN2A ID1 11507043 848053 Because the p16/Ink4a protein has been demonstrated to be inactivated in subsets of familial and sporadic melanomas , we sought to determine whether *regulation* of [p16/Ink4a] expression might be involved in the development of this human tumor . Regulation CDKN2A ID1 11507043 848055 These data suggest a *role* for in regulating [p16/Ink4a] expression in early melanomas and demonstrate that later genetic changes may provide for irreversible loss of p16 expression in advanced stages of this tumor . Regulation CDKN2A ID1 12949053 1158037 As p16INK4a protein is inactivated in hepatocellular carcinoma ( HCC ) , we aimed to investigate the *role* of in regulating [p16INK4a] expression during the development of HCC in HCC patients and direct ectopic Id-1 introduction into the PLC/PRF/5 HCC cell line . Regulation CDKN2A IFI27 19858485 2165561 Furthermore , we show that the roles of p16(Ink4a) and p27 ( Kip1 ) in the control of contact inhibition became temporally separated in this species : the early contact inhibition is controlled by [p16(Ink4a)] , and regular contact inhibition is *controlled* by ( Kip1 ) . Regulation CDKN2A ZFP57 20808772 2314158 Our findings implicate in the transcriptional *regulation* of the [Ink4a/Arf] locus and suggest that the interaction of Zfp277 with Bmi1 is essential for the recruitment of PRC1 to the Ink4a/Arf locus . Regulation CDKN2B EPHB2 15917995 1413225 We have demonstrated that ( MAPK ) signaling was *involved* in the induction of both [p15(INK4b)and] p16(INK4a) CDK inhibitors and growth inhibition of hepatoma cell HepG2 triggered by the tumor promoter tetradecanoyl phorbol acetate ( TPA ) . Regulation CDX2 IL1B 20658368 2297959 To evaluate the *effect* of on the expression of [CDX2] in human gastric epithelial cell line GES-1 and its role in the intestinal metaplasia . Regulation CDX2 TNF 12360479 994921 PTEN and *regulation* of the intestinal-specific [Cdx-2] homeobox gene through a PI3K , PKB/Akt , and NF-kappaB dependent pathway . Regulation CDX2 TNF 24501326 2933213 Inhibition of nuclear factor-kappaB or p38 pathways showed that these are involved in the *dependent* downregulation of [CDX2] . Regulation CEACAM6 CALM3 7654391 321154 However , depletion of extracellular calcium inhibited the release of [NCA] in *response* to both ETX and OZ . inhibitors , compound 48/80 and N- ( 6-aminohexyl ) -1 naphthalenesulfonamide ( W-7 ) , inhibited the release of NCA in response to a variety of endotoxin concentrations . Regulation CEACAM6 FGFR3 1566862 186873 BEC released [NCA] and MCA in *response* to in a dose dependent and time dependent manner . Regulation CEACAM6 FGFR3 1566862 186875 Nicotine , the nicotinic receptor antagonist d-tubocurarine , and the M2 receptor antagonist gallamine did not modulate the release of [NCA] in *response* to . Regulation CEACAM6 PRKACB 9689054 522712 The *effect* of cAMP dependent on [nuclear Ca2+-ATPase (NCA)] was studied by using purified rat liver nuclei . Regulation CEACAM6 PRKACG 9689054 522713 The *effect* of cAMP dependent on [nuclear Ca2+-ATPase (NCA)] was studied by using purified rat liver nuclei . Regulation CEACAM6 PRKAR1A 9689054 522714 The *effect* of cAMP dependent on [nuclear Ca2+-ATPase (NCA)] was studied by using purified rat liver nuclei . Regulation CEACAM6 PRKAR1B 9689054 522715 The *effect* of cAMP dependent on [nuclear Ca2+-ATPase (NCA)] was studied by using purified rat liver nuclei . Regulation CEACAM6 PRKAR2A 9689054 522716 The *effect* of cAMP dependent on [nuclear Ca2+-ATPase (NCA)] was studied by using purified rat liver nuclei . Regulation CEACAM6 PRKAR2B 9689054 522717 The *effect* of cAMP dependent on [nuclear Ca2+-ATPase (NCA)] was studied by using purified rat liver nuclei . Regulation CEACAM6 SMPD1 10930579 719986 is *involved* in [CEACAM] receptor mediated phagocytosis of Neisseria gonorrhoeae . Regulation CEACAM6 SOX9 19637360 2182917 Defect in [CEACAM] family member expression in Crohn 's disease IECs is *regulated* by the . Regulation CEACAM6 SOX9 19637360 2182929 Since [CEACAM] expression was shown to be *regulated* by the , we sought to determine whether the defect in CEACAM expression in IBD was related to aberrant SOX9 expression . Regulation CEBPA FOXO1 19585174 2182771 By comparison , did not *affect* the expression of [C/EBP-ß] or C/EBP-d during the early period of adipocyte differentiation . Regulation CEBPA IL1B 16106045 1466632 In this study , we investigate the role of ceramide in the *regulation* of [C/EBP] in primary hepatocytes . Regulation CEBPA IL1B 16865359 1592776 Down-regulation of peroxisome proliferating activated receptor gamma and [CCAAT/enhancer binding protein alpha] in *response* to may have contributed to the altered phenotype of IL1B treated adipocytes . Regulation CEBPB DAPK1 22874566 2710060 IFNG stimulated proteolytic cleavage of ATF6 , and MAPK1/3 ( ERK2/1 ) -dependent phosphorylation of [CEBPB] together *control* the expression of . Regulation CEBPB EPHB2 16453302 1540716 Interleukin-1 beta induction of matrix metalloproteinase-1 transcription in chondrocytes requires *dependent* activation of [CCAAT enhancer binding protein-beta] . Regulation CEBPB EPHB2 19276382 2046267 Ras ( V12 ) -induced silencing of [C/EBPbeta] occurred at the mRNA level and *involved* both the Raf-mitogen activated protein/extracellular signal regulated kinase ( ERK ) and phosphatidylinositol 3-kinase signaling pathways . Regulation CEBPB EPHB2 21890597 2506413 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and *dependent* activation of the [CCAAT/enhancer binding protein beta] transcription factor independent of p53 . Regulation CEBPB TNF 18438857 1915462 The *effect* of on endogenous binding of [c/EBPbeta] or SOX9 to the cd-rap promoter was examined by chromatin immunoprecipitation assays . Regulation CEMP1 EPHB2 20440482 2288111 Ca ( OH ) ( 2 ) stimulated expression of the cementum-specific proteins [CEMP1] and PTPLA/CAP in an *dependent* manner . Regulation CENPA STK39 18083840 1837602 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation CENPE STK39 18083840 1837617 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation CENPF STK39 18083840 1837632 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation CERK NR2F1 22579669 2619441 Notably , the treatment of SH-SY5Y cells with ZK159222 , antagonist of 1,25 ( OH ) 2D3 receptor , trichostatin A , inhibitor of histone deacetylases , and COUP-TFI-siRNA prevented the decrease of CerK expression elicited by 1,25 ( OH ) 2D3 supporting the *involvement* of deacetylase complex in [CerK] regulation . Regulation CES1 TNF 19189937 2071621 We hypothesize that may be *involved* in regulating the [ACAT] gene expression in monocytes/macrophages . Regulation CFD TNF 8923470 397268 Low level constitutive expression of PPAR gamma in 3T3-L1 adipocytes ( at levels approximately 2- to 3-fold higher than in preadipocytes ) partially blocked the inhibitory *effect* of on aP2 and [adipsin] expression . Regulation CFI IL1A 9804975 544629 We have investigated the *effects* of and IL-6 on human [complement factor I (CFI)] production by Hep G2 cells . Regulation CFI IL6 9804975 544628 Transcriptional and post-transcriptional *regulation* of [complement factor I (CFI)] gene expression in Hep G2 cells by . Regulation CFI IL6 9804975 544630 We have investigated the *effects* of IL-1 and on human [complement factor I (CFI)] production by Hep G2 cells . Regulation CFL1 EPHB2 19553453 2099488 Further , we found that mediated *regulation* of [cofilin] activity at least partially depends on the activation of Rho associated kinase (ROCK) and LIMK-1 . Regulation CFL1 EPHB2 20610540 2309743 LHR dependent Rho inactivation and subsequent activation of [cofilin] does not *involve* , epidermal growth factor receptor , or phosphatidylinositol 3-kinase pathways downstream of PKA . Regulation CFL1 RGS16 20511347 2301295 However , UTP induced phosphorylation of [cofilin] was not *affected* by the expression of , which inhibits the G(12/13) signaling pathway . Regulation CFL1 RGS2 20511347 2301296 However , UTP induced phosphorylation of [cofilin] was not *affected* by the expression of , which inhibits the G(12/13) signaling pathway . Regulation CFL1 TGM2 21355047 2415640 By live cell fluorescence lifetime imaging measurement-Förster resonant energy transfer studies and western blot assays , we quantitatively observed that stress activated 2 ( TG2 ) is *responsible* for the [actin-cofilin] covalent cross linking observed in HD . Regulation CFL2 EPHB2 19553453 2099493 Further , we found that mediated *regulation* of [cofilin] activity at least partially depends on the activation of Rho associated kinase (ROCK) and LIMK-1 . Regulation CFL2 EPHB2 20610540 2309745 LHR dependent Rho inactivation and subsequent activation of [cofilin] does not *involve* , epidermal growth factor receptor , or phosphatidylinositol 3-kinase pathways downstream of PKA . Regulation CFL2 RGS16 20511347 2301317 However , UTP induced phosphorylation of [cofilin] was not *affected* by the expression of , which inhibits the G(12/13) signaling pathway . Regulation CFL2 RGS2 20511347 2301318 However , UTP induced phosphorylation of [cofilin] was not *affected* by the expression of , which inhibits the G(12/13) signaling pathway . Regulation CFL2 TGM2 21355047 2415641 By live cell fluorescence lifetime imaging measurement-Förster resonant energy transfer studies and western blot assays , we quantitatively observed that stress activated 2 ( TG2 ) is *responsible* for the [actin-cofilin] covalent cross linking observed in HD . Regulation CFLAR FAS 17112511 1676716 We have reported recently that K8/K18-free hepatocytes from K8-null mice are more sensitive to Fas mediated apoptosis , in line with an increased density at the cell surface and an altered [c-Flip] *regulation* of the anti-apoptotic ERK1/2 signaling pathway . Regulation CFLAR TNFSF10 12556488 1051673 Our results show that c-FLIP ( L ) and [c-FLIP] ( S ) potently *control* responses , both by distinct regulatory features , and further imply that the differentiation state of malignant cells determines their sensitivity to death receptor signals . Regulation CFP JAG1 6193221 29891 CRIA+ as was , to a slightly lesser extent ( greater than 75 % ) the CRI+ portion of secondary or hyperimmune serum Ab or [PFC] *responses* to the same . Regulation CFP JAG1 6193221 29892 The most striking disparity from the TD pattern was seen in primary in vitro [PFC] *responses* to the TI ABA ; Regulation CFP TCN1 3159691 48955 *Effects* of on [PFC] responses in vitro were reversible if cells briefly exposed to an optimal concentration of drug were washed extensively prior to immunization . Regulation CFP TF 2646374 108715 RIIIS/J mice treated with LPS produce a low anti-bromelain treated mouse RBC splenic plaque forming cell response and a normal anti-mouse splenic [PFC] *response* . Regulation CFTR IL1B 10657593 664039 *regulates* [CFTR] expression in human intestinal T84 cells . Regulation CFTR IL1B 10657593 664040 In this work , we have examined the *effects* of on the expression of [CFTR] in human colonic T84 cells . Regulation CFTR IL1B 11114294 786555 We have investigated the *effect* of the pro-inflammatory peptide on the expression of the [CFTR] in Calu-3 cells . Regulation CFTR MUC16 9831904 551563 7. Correction of the defective [CFTR] secretion *response* did not correlate with ability to stimulate mucin secretion and did not require potentiation of beta-adrenergic induced increases in cyclic AMP . Regulation CGA EDN2 2163546 136040 Although intracellular calcium concentration and [gonadotropin] secretory *responses* to were independent to the GnRH receptor , endothelin and GnRH appeared to have a common signal transduction mechanism . Regulation CGA EPHB2 18558406 1940748 More importantly , the present study suggests that GnRH induced [gonadotropin] subunit gene expression and LH release *involve* signaling in goldfish . Regulation CGA IL1B 10792581 689317 *Effect* of on [gonadotropin releasing hormone (GnRH)] and GnRH receptor gene expression in castrated male rats . Regulation CGA IL1B 7623615 315929 *Effect* of , tumour necrosis factor-alpha and interleukin-6 on the control of [thyrotropin] secretion . Regulation CGA IL1B 8243260 236500 Taken together , these data suggest that the primary *effect* of is at the level of LHRH perikarya , and that the resulting interruption of the cycle is caused by altered LHRH neuronal activity and blunted [gonadotropin] secretion . Regulation CGA IL1B 8612490 353128 *Effects* of on [thyrotropin] secretion and thyroid hormone uptake in cultured rat anterior pituitary cells . Regulation CGA MAP2K6 18558406 1940754 More importantly , the present study suggests that GnRH induced [gonadotropin] subunit gene expression and LH release *involve* signaling in goldfish . Regulation CGA TNF 19501915 2103002 The *effects* of on CYP24A1 , chorionic [gonadotropin] ( hCG ) , 3beta-hydroxysteroid dehydrogenase ( HSD3B1 ) and P ( 450 ) -aromatase ( CYP19 ) mRNA expression were also studied . Regulation CGA TNF 7479297 331849 We examined the chronic ( 72 h ) *effects* of 30 ng/ml recombinant murine on release of immunoreactive growth hormone (GH) , prolactin (PRL) , [thyrotropin] ( TSH ) , and TSH glycosylation , as assessed by lectin binding , in cultured rat anterior pituitary cells . Regulation CGB8 EDN2 2163546 136037 Although intracellular calcium concentration and [gonadotropin] secretory *responses* to were independent to the GnRH receptor , endothelin and GnRH appeared to have a common signal transduction mechanism . Regulation CGB8 EPHB2 18558406 1940740 More importantly , the present study suggests that GnRH induced [gonadotropin] subunit gene expression and LH release *involve* signaling in goldfish . Regulation CGB8 IL1B 10792581 689316 *Effect* of on [gonadotropin releasing hormone (GnRH)] and GnRH receptor gene expression in castrated male rats . Regulation CGB8 IL1B 8243260 236499 Taken together , these data suggest that the primary *effect* of is at the level of LHRH perikarya , and that the resulting interruption of the cycle is caused by altered LHRH neuronal activity and blunted [gonadotropin] secretion . Regulation CGB8 MAP2K6 18558406 1940746 More importantly , the present study suggests that GnRH induced [gonadotropin] subunit gene expression and LH release *involve* signaling in goldfish . Regulation CGB8 TNF 19501915 2103001 The *effects* of on CYP24A1 , chorionic [gonadotropin] ( hCG ) , 3beta-hydroxysteroid dehydrogenase ( HSD3B1 ) and P ( 450 ) -aromatase ( CYP19 ) mRNA expression were also studied . Regulation CHGA TNF 18719026 1984926 IkappaBalphaS/A and IkappaBalphaTrunc ameliorated the inhibitory *effects* of on GH-inducible [Spi] 2.1 and IGF-I promoter activity . Regulation CHI3L1 AVP 16488162 1567661 *Effects* of and parathyroid hormone related protein ( 1-34 ) on cell proliferation and production of [YKL-40] in cultured chondrocytes from patients with rheumatoid arthritis and osteoarthritis . Regulation CHI3L1 AVP 16488162 1567663 We therefore investigated the *effects* of and PTHrP ( 1-34 ) on cell proliferation and secretion of the glycoprotein [YKL-40] in human chondrocytes derived from healthy subjects as well as from patients with RA or osteoarthritis ( OA ) . Regulation CHI3L1 AVP 16488162 1567667 However , the *effects* of and PTHrP ( 1-34 ) on [YKL-40] secretion varied depending on the origin of the chondrocytes . Regulation CHI3L1 IL1B 11315922 806431 This , coupled with the profound suppressive *effects* of and TGFbeta on [YKL-40] production , identifies a novel regulatory pattern for this major chondrocyte derived protein . Regulation CHI3L1 IL6 21478032 2434034 To study the possible *role* of and tumor necrosis factor (TNF)-a in the regulation of [YKL-40] plasma levels , we included healthy men , who received either recombinant human ( rh ) IL-6 ( n=6 ) , rhTNF-a ( n=8 ) or vehicle ( n=7 ) for 3h . Regulation CHI3L1 IL6 24570843 2919774 The *Effect* of Recombinant Human on Osteogenic Differentiation and [YKL-40] Expression in Human , Bone Marrow Derived Mesenchymal Stem Cells . Regulation CHI3L1 IL6 24570843 2919775 The aim of this study was to determine the *effect* of recombinant human ( 5 ng/mL ) on [YKL-40] expression and osteogenic differentiation of human mesenchymal stem cells . Regulation CHI3L1 MAX 17160890 1678948 Third , we found that an allele of SNP4 ( rs4950928 ) , the tagging SNP of CCC , impaired the *regulated* transcriptional activation of [CHI3L1] by altering the transcriptional-factor consensus sequences , and this may be responsible for the decreased expression of the CCC haplotype . Regulation CHI3L1 MYC 17160890 1678949 Third , we found that an allele of SNP4 ( rs4950928 ) , the tagging SNP of CCC , impaired the *regulated* transcriptional activation of [CHI3L1] by altering the transcriptional-factor consensus sequences , and this may be responsible for the decreased expression of the CCC haplotype . Regulation CHI3L1 NFIX 21953450 2507268 Furthermore , [YKL-40] is a migration factor for primary astrocytes , and its expression is *controlled* by both and STAT3 , which are known regulators of gliogenesis . Regulation CHI3L1 PTHLH 16488162 1567662 *Effects* of arginine-vasopressin and ( 1-34 ) on cell proliferation and production of [YKL-40] in cultured chondrocytes from patients with rheumatoid arthritis and osteoarthritis . Regulation CHI3L1 PTHLH 16488162 1567664 We therefore investigated the *effects* of AVP and ( 1-34 ) on cell proliferation and secretion of the glycoprotein [YKL-40] in human chondrocytes derived from healthy subjects as well as from patients with RA or osteoarthritis ( OA ) . Regulation CHI3L1 PTHLH 16488162 1567668 However , the *effects* of AVP and ( 1-34 ) on [YKL-40] secretion varied depending on the origin of the chondrocytes . Regulation CHI3L1 STAT3 21953450 2507267 Furthermore , [YKL-40] is a migration factor for primary astrocytes , and its expression is *controlled* by both NFI-X3 and , which are known regulators of gliogenesis . Regulation CHI3L1 TNF 21478032 2434033 To study the possible *role* of interleukin-6 (IL-6) and in the regulation of [YKL-40] plasma levels , we included healthy men , who received either recombinant human ( rh ) IL-6 ( n=6 ) , rhTNF-a ( n=8 ) or vehicle ( n=7 ) for 3h . Regulation CHKA TFPI2 21921034 2506885 A comparable *role* for in the regulation of [Chk1] phosphorylation was also observed in human cells . Regulation CHUK IL1B 12934647 1132838 Salicylate inhibited the and TNF-alpha induced COX-2 expressions , *regulated* the activation of ERK , [IKK] and IkappaB degradation , and the subsequent activation of NF-kappaB , in neonatal rat ventricular cardiomyocytes . Regulation CHUK MAP2K6 16584774 1665827 Together , we interpret these data as demonstrating that the activation caused by loss of Gimap5 is a cell intrinsic phenomenon caused , in part , by a *dependent* activation of [IKK] . Regulation CHUK TLR7 22473004 2589087 NLRC5 ablation reduces MHC class I expression , and enhances [IKK] and IRF3 phosphorylation in *response* to stimulation or viral infection . Regulation CHUK TNF 10455128 638513 Differential *effects* of lipopolysaccharide and on monocytic [IkappaB kinase] signalsome activation and IkappaB proteolysis . Regulation CHUK TNF 11359906 816588 The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2 dependent [IKK] recruitment to tumor necrosis factor (TNF) receptor 1 in *response* to . Regulation CHUK TNF 11359906 816594 In *response* to the proinflammatory cytokine , [IKK] is activated after being recruited to the TNF receptor 1 (TNF-R1) complex via TNF receptor associated factor 2 (TRAF2) . Regulation CHUK TNF 11429546 831659 The molecular mechanism that underlies [IKK] activation in *response* to is still unknown . Regulation CHUK TNF 15536134 1336412 In addition , we demonstrate that both [IkappaB kinase-alpha] and -beta are simultaneously recruited to the hes1 promoter in *response* to , coinciding with a maximum of IkappaBalpha release and gene activation . Regulation CHUK TNF 16115877 1474132 Rip1 is required for [IkappaB kinase] activation in *response* to and has been implicated in the Toll-like receptor 3 (TLR3) response to double stranded RNA . Regulation CHUK TNF 16115877 1474141 These studies suggest that Rip1 uses a similar , ubiquitin dependent mechanism to activate [IkappaB kinase-beta] in *response* to and TLR3 ligands . Regulation CHUK TNF 16611882 1545340 Similarly , IKKgamma-delta mediates [IKK] kinase activity and downstream NF-kappaB dependent transcription in *response* to and the NF-kappaB inducing kinase-IKKalpha signaling pathway . Regulation CHUK TNF 17244613 1710252 Our results therefore demonstrate that NEMO and IKKalpha can form a functional [IKK complex] that activates the classical NF-kappaB pathway in *response* to IL-1 but not . Regulation CHUK TNF 19336568 2056506 Tumor necrosis factor (TNF) receptor associated factor 2 ( TRAF2 ) is an adaptor protein that modulates the activation of the c-Jun NH ( 2 ) terminal kinase ( JNK ) /c-Jun and [IkappaB kinase (IKK)/nuclear] factor-kappaB (NF-kappaB) signaling cascades in *response* to stimulation . Regulation CHUK TNF 9710600 526825 Our studies now demonstrate that HTLV-1 Tax activates the recently identified cellular kinases [IkappaB kinase alpha (IKKalpha)] and IKKbeta , which normally phosphorylate IkappaB alpha on both of its N-terminal regulatory serines in *response* to and interleukin-1 (IL-1) stimulation . Regulation CHUK TNF 9819420 547289 MEKK1 is activated by tumor necrosis factor alpha (TNF-alpha) and interleukin-1 and can potentiate the stimulatory *effect* of on [IKK] and NF-kappaB activation . Regulation CIB1 CCND1 10603039 574996 [p27/kip1] *regulates* the G1-S transition of the cell cycle by inhibiting , cyclinE-CDK2 and cyclinA-CDK2 complexes . Regulation CIB1 EPHB2 19492998 2091375 The NFkB dependent drop in cyclin D1 , along with the *dependent* induction of p21 [Cip1/Kip1] , is responsible for growth arrest . Regulation CIB1 FOXO1 15087469 1258120 These studies demonstrate for the first time that can *regulate* [p27kip] nuclear localization . Regulation CIB1 FOXO1 16631585 1552482 *regulates* transcription of [cki-1/Cip/Kip] and repression of lin-4 during C. elegans L1 arrest . Regulation CIB1 FOXO1 17015685 1629788 Consistent with the important *role* of in p27 [kip1] transcription , stimulated Vav1 ( -/- ) T cells failed to down-regulate the expression of p27 kip1 , explaining their G0-G1 arrest . Regulation CIB1 IFI27 19819988 2154607 BMP-4 induction of arrest and differentiation of osteoblast-like cells via p21 CIP1 and [KIP1] *regulation* . Regulation CIB1 TNF 21075101 2371463 *regulates* p27 [kip] expression and apoptosis in smooth muscle cells of human carotid plaques via forkhead transcription factor O1 . Regulation CIC FOXA1 19445897 2090626 These results show that *plays* a role in the transcriptional regulation of [CIC] and in insulin secretion . Regulation CIDEB PGC 24161736 2868215 This activation occurs through the induced expression of , a positive transcriptional *regulator* of [CIDEB] . Regulation CIITA EPHB2 16785500 1577003 and p38 MAPK signaling pathways negatively *regulate* [CIITA] gene expression in dendritic cells and macrophages . Regulation CISH ABCA4 23144455 2710779 The results suggest a possible *role* of and , in particular , the NBD1 domain in [11-cis-retinal] binding . Regulation CISH EDN2 1314833 185343 Differential *regulation* of fos and jun gene expression and AP-1 [cis-element] activity by isopeptides . Regulation CISH EPHB2 18922468 1977203 Autophosphorylation occurs in [cis] , does not *involve* activation , and is essential to ensure the correct folding and stability of the protein . Regulation CISH MAP2K6 11727828 884587 We analyzed the *role* of for IL-6 signal transduction and transcriptional activation of the [suppressor of cytokine signaling (SOCS)] 3 promoter . Regulation CISH MAP2K6 18922468 1977209 Autophosphorylation occurs in [cis] , does not *involve* activation , and is essential to ensure the correct folding and stability of the protein . Regulation CISH TNF 18820827 1987677 These data suggest that CIS can serve as an SLE disease marker and may be involved in the pathogenesis of SLE , and that may *play* an important role in the regulation of [CIS] and SOCS2 gene expression in PBMCs in vivo . Regulation CKAP4 TP63 21820419 2490437 Therefore , we propose a potential biological *role* of interaction in regulation of [p63] during epidermal differentiation . Regulation CKAP5 STK39 18083840 1837737 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation CKS1B CCND1 16924241 1692245 Mutant B-RAF signaling and *regulate* [Cks1/S-phase] kinase associated protein 2-mediated degradation of p27Kip1 in human melanoma cells . Regulation CKS1B CCND1 16924241 1692255 Importantly , expression of [Cks1] is *regulated* by B-RAF and at the mRNA level . Regulation CLASP1 STK39 18083840 1837542 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation CLASP2 STK39 18083840 1837527 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation CLDN10 CDX2 18251778 1865349 These findings suggest that *plays* an important role in the regulation of intestinal [claudin] expression not only in gastric mucosa with IM but also GC . Regulation CLDN10 CLDN1 18204077 1876497 Activation of RON differentially *regulates* [claudin] expression and localization : role of in RON mediated epithelial cell motility . Regulation CLDN10 EGFR 14593119 1200088 activation differentially *regulates* [claudin] expression and enhances transepithelial resistance in Madin-Darby canine kidney cells . Regulation CLDN10 EGFR 17855771 1818181 Juxtacrine activation of *regulates* [claudin] expression and increases transepithelial resistance . Regulation CLDN10 IFNG 16232214 1470353 Since the claudin family of tight junction proteins is proposed to be involved in barrier maintenance we studied the *effect* of on [claudin] expression in relation to epithelial barrier function . Regulation CLDN10 IFNG 17582238 1768038 lipopolysaccharide , and tumour necrosis factor-alpha had no *effect* on [claudin] protein expression or distribution . Regulation CLDN10 IL17A 10833473 697741 To determine the functional role of immune mediators in the formation of the intestinal barrier , we have examined the *regulation* of [claudin] expression by in human intestinal epithelial cells . Regulation CLDN10 MST1R 18204077 1876498 Activation of differentially *regulates* [claudin] expression and localization : role of claudin-1 in RON mediated epithelial cell motility . Regulation CLDN10 MST1R 18204077 1876565 We report here that activation of differentially *regulates* tight junction function and [claudin] expression . Regulation CLDN10 MST1R 18204077 1876613 In conclusion , activation differentially *regulates* [claudin] expression in epithelial cells . Regulation CLDN10 PAEP 23813140 2808226 Our aim was to investigate if plus RBV *regulate* [claudin] expression . Regulation CLDN10 WNK1 16949040 1615560 Using these cell lines , we investigated whether increased expression might *affect* paracellular chloride permeability and [claudin] phosphorylation , since we previously observed an increase in both with a disease causing mutant WNK4 . Regulation CLDN16 EPHB2 19914201 2209904 These results suggest that the *dependent* phosphorylation of [claudin-16] affects the tight junctional localization and function of claudin-16 . Regulation CLDN16 MAP2K6 19914201 2209910 These results suggest that the *dependent* phosphorylation of [claudin-16] affects the tight junctional localization and function of claudin-16 . Regulation CLDN2 IL1B 15350541 1292418 *regulates* expression of Cx32 , occludin , and [claudin-2] of rat hepatocytes via distinct signal transduction pathways . Regulation CLDN2 TNF 19214581 2105882 Our aim has been to characterize the molecular mechanisms regulating the expression of the channel forming tight-junctional protein [claudin-2] in *response* to the pro-inflammatory cytokine , which is elevated , for example , in active Crohn 's disease . Regulation CLDN2 TNF 22848704 2635922 Our data demonstrate that the previously established efficacy of VSL # 3 in preventing SAMP ileitis is due to direct innate and homeostatic *effects* of on the gut epithelium , modulation of the TJ proteins , [claudin-2] and occludin , and overall improvement of intestinal permeability . Regulation CLDN4 EPHB2 20861219 2337097 Further experiments indicated that p44/42 is not *involved* in the transcriptional regulation of [claudin-4] . Regulation CLDN5 FOXO1 24028293 2902155 Moreover , simvastatin treatment of ECs induced increased phosphorylation of both and ß-catenin , transcriptional *regulators* of [claudin-5] expression mediated by VE-cadherin . Regulation CLIC4 TNF 16358817 1492992 [Chloride intracellular channel (CLIC)4] is a p53- and *regulated* chloride channel protein that is localized to the mitochondria and cytoplasm of mouse and human keratinocytes . Regulation CLIP1 STK39 18083840 1837467 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation CLMP TNF 18047469 1867323 In the present study , we sought to examine the detailed mechanism on how *affects* the expression of [CLMP] ( coxsackie- and adenovirus-receptor-like membrane protein ) , a newly identified tight junction transmembrane protein , in the testis . Regulation CLTA TNF 20564232 2290303 Immunoprecipitation studies revealed associations of NM IIB with [clathrin] , FADD , and caspase 8 in *response* to suggesting a role for NM IIB in TNFR1 endocytosis and the formation of the death inducing signaling complex (DISC) . Regulation CLTC TNF 20564232 2290304 Immunoprecipitation studies revealed associations of NM IIB with [clathrin] , FADD , and caspase 8 in *response* to suggesting a role for NM IIB in TNFR1 endocytosis and the formation of the death inducing signaling complex (DISC) . Regulation CLU ACE 18949565 1989221 The *effects* of inhibitor and angiotensin receptor blocker on [clusterin] and apoptosis in the kidney tissue of streptozotocin-diabetic rats . Regulation CLU ANGPT2 10712283 673992 This study was designed to examine the *regulation* of renal TGF-beta1 and [clusterin] by in the neonatal rat . Regulation CLU APOE 10940295 744034 However , the effects of Abeta on endogenous apoE and [apoJ] levels and the potential *role* of receptors in astrocyte activation have not been addressed . Regulation CLU CA2 9537999 497595 The binding of biotinylated heparin to [clusterin] was *independent* of the presence or absence of . Regulation CLU DAB2IP 23838317 2834670 Western blot , quantitative PCR , and luciferase reporter assays were used to analyze [Clusterin] gene *regulation* by . Regulation CLU EGR1 15689620 1388522 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Regulation CLU EPHB2 19166932 2038512 Taken together , our data suggest that [CLU] may *regulate* EMT and aggressive behaviour of human lung adenocarcinoma cells through modulating signalling and Slug expression . Regulation CLU F11 24126506 2853260 Various studies have evaluated the *role* of in DF and [CLI] that resulted favourable in terms of feasibility , technical efficacy , the reduced number of complications , and limb salvage rates . Regulation CLU F2R 9189857 437511 The protein kinase C inhibitor RO-32-0432 ( 1 microM ) inhibited the thrombin induced increase in clusterin mRNA , suggesting that activation may *regulate* renal [clusterin] mRNA levels through protein kinase C . Regulation CLU FOS 10406964 629679 Here , we demonstrate , by supershift analysis , that JunB , JunD , Fra1 , Fra2 , and c-Fos bound to AP-1 but that prior treatment of the cells with TGFbeta reduced dramatically c-Fos binding , suggesting that might be playing a negative regulatory *role* in [clusterin] gene expression . Regulation CLU GAST 21995960 2526143 The [clusterin] *response* to was validated in vivo in hypergastrinemic rats , showing increased clusterin expression in the oxyntic mucosa , as well as higher levels of clusterin in plasma . Regulation CLU HIF1A 16414399 1514462 However , little is known about the endogenous angiogenic response and the *role* of in human [critical limb ischemia (CLI)] . Regulation CLU HRAS 10092212 560667 Differential *regulation* of the [clusterin] gene by and c-myc oncogenes and during apoptosis . Regulation CLU HSF1 19353783 2058028 We report that proteasome inhibition promotes both *dependent* [CLU] gene expression induction and protein accumulation due to reduced degradation . Regulation CLU HSPA5 22689054 2763391 *regulates* [clusterin] stability , retrotranslocation and mitochondrial localization under ER stress in prostate cancer . Regulation CLU IGF1 21460853 2469812 ATM dependent induction *regulates* secretory [clusterin] expression after DNA damage and in genetic instability . Regulation CLU IGF1R 15689620 1388523 Delayed activation of signaling *regulates* [clusterin] expression , a pro-survival factor . Regulation CLU IL24 21732348 2538862 differentially *regulates* soluble and nuclear [clusterin] in prostate cancer . Regulation CLU IL24 21732348 2538864 Here , we identify clusterin (CLU) as a MDA-7/IL-24 interacting protein in DU-145 cells and investigate the *role* of in regulating [CLU] expression and mediating the antitumor properties of mda-7/IL-24 in prostate cancer . Regulation CLU JUN 21995960 2526141 Luciferase reporter assay indicates that the transcription factor complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Regulation CLU MAPK1 15689620 1388524 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Regulation CLU MAPK10 15689620 1388525 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Regulation CLU MAPK11 15689620 1388526 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Regulation CLU MAPK12 15689620 1388527 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Regulation CLU MAPK13 15689620 1388528 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Regulation CLU MAPK14 15689620 1388529 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Regulation CLU MAPK15 15689620 1388521 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Regulation CLU MAPK3 15689620 1388530 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Regulation CLU MAPK3 24008723 2902133 Our data suggest that [CLU] may *regulate* aggressive behavior of human CRCC cells through modulating signaling and MMP-9 expression . Regulation CLU MAPK4 15689620 1388531 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Regulation CLU MAPK6 15689620 1388532 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Regulation CLU MAPK7 15689620 1388533 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Regulation CLU MAPK8 15689620 1388534 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Regulation CLU MAPK9 15689620 1388535 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Regulation CLU MYBL2 10770937 707642 Here we show that the human ApoJ/Clusterin gene contains a Myb binding site in its 5 ' flanking region , which interacts with bacterially synthesized B-MYB protein and mediates *dependent* transactivation of the [ApoJ/Clusterin] promoter in transient transfection assays . Regulation CLU MYBL2 15618219 1394892 We find that *regulation* of [ApoJ/clusterin] by is a pro-survival response to thermal stress . Regulation CLU SLC33A1 7611452 312155 *Regulation* of renal growth factors and [clusterin] by receptors during neonatal ureteral obstruction . Regulation CLU SNAI2 19166932 2038511 Taken together , our data suggest that [CLU] may *regulate* EMT and aggressive behaviour of human lung adenocarcinoma cells through modulating ERK signalling and expression . Regulation CLU SRC 15689620 1388520 Delayed activation of insulin-like growth factor-1 signaling *regulates* [clusterin] expression , a pro-survival factor . Regulation CLU SREBF1 21549685 2429252 *regulates* glucose stimulated hepatic [clusterin] expression . Regulation CLU SREBF1 21549685 2429253 Taken together , these results suggest that clusterin expression is increased by glucose stimulation , and *plays* a crucial role in the metabolic regulation of [clusterin] . Regulation CLU TCF12 21995960 2526130 Luciferase reporter assay indicates that the AP-1 complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Regulation CLU TCF15 21995960 2526131 Luciferase reporter assay indicates that the AP-1 complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Regulation CLU TCF19 21995960 2526132 Luciferase reporter assay indicates that the AP-1 complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Regulation CLU TCF20 21995960 2526133 Luciferase reporter assay indicates that the AP-1 complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Regulation CLU TCF21 21995960 2526134 Luciferase reporter assay indicates that the AP-1 complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Regulation CLU TCF23 21995960 2526138 Luciferase reporter assay indicates that the AP-1 complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Regulation CLU TCF24 21995960 2526140 Luciferase reporter assay indicates that the AP-1 complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Regulation CLU TCF25 21995960 2526139 Luciferase reporter assay indicates that the AP-1 complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Regulation CLU TCF3 21995960 2526135 Luciferase reporter assay indicates that the AP-1 complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Regulation CLU TCF4 21995960 2526136 Luciferase reporter assay indicates that the AP-1 complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Regulation CLU TCF7 21995960 2526137 Luciferase reporter assay indicates that the AP-1 complex is *involved* in gastrin mediated activation of the [clusterin] promoter . Regulation CLU TGFB1 10406964 629661 *regulates* [clusterin] gene expression via modulation of transcription factor c-Fos . Regulation CLU TGFB1 16639006 1552960 Real-time PCR and Western blot analysis were used to study the *effect* of , which is significantly increased in the aqueous humor of PEX eyes , on [clusterin] expression by nonpigmented ciliary epithelial cells in vitro . Regulation CLU TGFB1 7730444 302326 This study characterizes the *effect* of on [clusterin] expression in rat brain cells . Regulation CLU TGFB1 9189857 437509 Epidermal growth factor , insulin-like growth factor-1 , and had little or no *effect* on [clusterin] mRNA levels . Regulation CLU TGFB2 10406964 629662 *regulates* [clusterin] gene expression via modulation of transcription factor c-Fos . Regulation CLU TGFB3 10406964 629663 *regulates* [clusterin] gene expression via modulation of transcription factor c-Fos . Regulation CLU TWIST1 22896337 2682838 By binding to E-boxes in the distal promoter region of CLU gene , *regulated* basal and TGF-ß induced [CLU] transcription . Regulation CNP TLR7 23818205 2808326 [CNP] and NPR-B showed different characteristic on renal cortex at different pathological period in diabetes rats , and *regulated* their expression . Regulation CNP TNF 23141169 2763647 These data indicate that lipopolysaccharide , and IL-1ß *regulate* [CNP] production from canine vascular endothelium and of the stimulants tested , IL-1ß is the predominant inducing factor . Regulation CNTF IL6R 8427597 212424 [Ciliary neurotrophic factor] *regulates* fibrinogen gene expression in hepatocytes by binding to the . Regulation CNTF TNF 22974557 2697851 Real-time RT-PCR and Western blotting indicated that ES which was applied to different co-cultures and 661W cell conditioned media ( 661WCM ) -treated glia cultures had a prominent inhibitive effect on the secretion of interleukin (IL)-1ß and in microglia and a positive regulative *effect* on the production of brain derived neurotrophic factor (BDNF) and [ciliary neurotrophic factor (CNTF)] in Müller cells . Regulation COG2 FAS 2677200 119463 Discrepancies among fish oil studies regarding the *effects* of n-3 on [LDL-C] levels may be understood by noting that , in the majority of studies reporting reductions in LDL-C levels , saturated fat intake was lowered when switching from the control diet to the fish oil diet . Regulation COG2 PCSK9 23106476 2740597 Non-HDL-C , [LDL-C] , and apoB levels were *dependent* on PCSK9 in nonobese subjects ( p=0.01 for each ) , but not in obese subjects ( p > 0.50 ) , Accordingly , BMI interacted negatively with on non-HDL-C ( p=0.028 ) and apoB ( p=0.071 ) . Regulation COG2 PCSK9 24529132 2914908 These data suggest that the *regulation* of [LDL-C] by remains intact in CKD-HD patients . Regulation COIL RNASE1 23616925 2774894 Additionally , we provide evidence of specific [coilin] activity *regulation* , on both U2 and hTR transcripts , by phosphorylation of a single residue , serine 489 . Regulation COIL RNASE7 23616925 2774902 Additionally , we provide evidence of specific [coilin] activity *regulation* , on both U2 and hTR transcripts , by phosphorylation of a single residue , serine 489 . Regulation COL11A1 CTGF 17133596 1661443 However , the regulatory role of CTGF on SPARC appeared to be negative and very small , while the positive regulatory *effects* of on COL1A2 , COL3A1 , [COL11A1] , and TIMP3 were less than those of SPARC . Regulation COL1A1 CTGF 19565505 2104345 This study was undertaken to investigate the *role* of in enhanced expression of [type I collagen] in bleomycin induced lung fibrosis , and to delineate the mechanisms of action underlying the effects of CTGF on Col1a2 ( collagen gene type I alpha2 ) in this mouse model and in human pulmonary fibroblasts . Regulation COL1A1 EPHB2 21757573 2515916 *Involvement* of JNK-AP-1 and signaling in tension stimulated expression of [type I collagen] and MMP-1 in human periodontal ligament fibroblasts . Regulation COL1A1 EPHB2 23159876 2718019 Furthermore , we show that p38 or MAPK signaling is required for maximal transcriptional *effects* on [Col1a1] expression . Regulation COL1A1 EPHB2 24352008 2881363 Furthermore , CH-induced COL1A1 gene expression was completely abolished by extracellular signal regulated kinase ( ERK ) inhibitor , suggesting the involvement of signaling for transcriptional *effects* on [COL1A1] expression . Regulation COL1A1 IL1B 17518712 1762071 Systemic differences coincided with varied *effects* of and IGF-I on cell growth and [type I collagen] expression . Regulation COL1A1 MMP28 18650553 1942519 We showed that Emdogain enhanced cell mediated degradation of [type I collagen] in an *dependent* manner . Regulation COL1A1 MMP7 18650553 1942534 We showed that Emdogain enhanced cell mediated degradation of [type I collagen] in an *dependent* manner . Regulation COL1A1 TNF 19298660 2056106 In contrast to epithelial cells , mesenchymal cells require 3-dimensional [type-I collagen] in *response* to to massively express MMP-9 . Regulation COL1A1 TNF 8621730 360154 Previous studies have shown that transforming growth factor-beta ( TGF-be ta ) and *modulate* [type I collagen] gene expression in fibroblasts . Regulation COL1A2 CTGF 17133596 1661444 However , the regulatory role of CTGF on SPARC appeared to be negative and very small , while the positive regulatory *effects* of on [COL1A2] , COL3A1 , COL11A1 , and TIMP3 were less than those of SPARC . Regulation COL1A2 CTGF 19565505 2104346 This study was undertaken to investigate the role of CTGF in enhanced expression of type I collagen in bleomycin induced lung fibrosis , and to delineate the mechanisms of action underlying the *effects* of on [Col1a2] ( collagen gene type I alpha2 ) in this mouse model and in human pulmonary fibroblasts . Regulation COL1A2 EPHB2 21757573 2515918 *Involvement* of JNK-AP-1 and signaling in tension stimulated expression of [type I collagen] and MMP-1 in human periodontal ligament fibroblasts . Regulation COL1A2 IL1B 17518712 1762073 Systemic differences coincided with varied *effects* of and IGF-I on cell growth and [type I collagen] expression . Regulation COL1A2 MMP28 18650553 1942541 We showed that Emdogain enhanced cell mediated degradation of [type I collagen] in an *dependent* manner . Regulation COL1A2 MMP7 18650553 1942556 We showed that Emdogain enhanced cell mediated degradation of [type I collagen] in an *dependent* manner . Regulation COL1A2 TNF 19298660 2056107 In contrast to epithelial cells , mesenchymal cells require 3-dimensional [type-I collagen] in *response* to to massively express MMP-9 . Regulation COL1A2 TNF 8621730 360158 Previous studies have shown that transforming growth factor-beta ( TGF-be ta ) and *modulate* [type I collagen] gene expression in fibroblasts . Regulation COL2A1 CCND1 17454300 1730125 *Regulation* of [type II collagen] expression by cyclin dependent kinase 6 , , and p21 in articular chondrocytes . Regulation COL2A1 CCND1 17454300 1730139 Our results collectively indicate that complex *regulates* [type II collagen] expression in articular chondrocytes . Regulation COL2A1 CTGF 20819546 2318392 This study aimed to establish an in vitro cell culture model of rhesus monkey lumbar intervertebral discs and to investigate the *effect* of combined and tissue inhibitor of metalloprotease-1 ( TIMP-1 ) expression mediated by adeno associated virus ( AAV ) on [collagen type II] and proteoglycan levels . Regulation COL2A1 CTGF 21928342 2539152 In this study we demonstrate that Wif-1 is capable to interfere with *dependent* induction of Acan and [Col2a1] gene expression in primary murine chondrocytes . Regulation COL2A1 IL1B 12888570 1142860 Specificity of *effects* on [COL2A1] promoter activity was demonstrated in experiments in which transfection of a wild type -50/+1 sequence of COL2A1 promoter as a decoy oligonucleotide abolished the IL-1 beta inhibition of a -63/+47 COL2A1 mediated transcription . Regulation COL2A1 IL1B 16754689 1590193 Opposing roles of WNT-5A and WNT-11 in *regulation* of [type II collagen] expression in articular chondrocytes . Regulation COL2A1 IL1B 20133941 2227004 Transient overexpression of Ank counteracted most of *effects* on [Type II collagen] , Sox-9 , and Wnt-5a expression . Regulation COL2A1 MMP28 9008612 410861 In some experiments , the *effects* of specific inhibitors on [type II collagen] degradation were studied . Regulation COL2A1 MMP7 9008612 410876 In some experiments , the *effects* of specific inhibitors on [type II collagen] degradation were studied . Regulation COL2A1 TNF 19778432 2163662 increased matrix metalloproteinase (MMP)-3 and a disintegrin and metalloproteinase with thrombospondin motifs ( ADAMTS)-4 mRNA expression , whereas collagen type I was decreased , and aggrecan , [collagen type II] as well as MMP-1 , -2 , -13 and ADAMTS-5 were variably *affected* . Regulation COL7A1 IL1B 15810887 1392140 The present study was designed to investigate the *effects* of TNF-alpha and on [COL7A1] expression in epidermal keratinocytes . Regulation COL7A1 TNF 15810887 1392139 The present study was designed to investigate the *effects* of and IL-1beta on [COL7A1] expression in epidermal keratinocytes . Regulation COL7A1 TNF 8276802 247230 Interestingly , IL-1 , and LR had additive *effects* with transforming growth factor-beta ( TGF-beta ) on [type VII collagen] gene expression , whereas they counteracted the up-regulatory effect of TGF-beta on type I collagen gene expression . Regulation CORT IL1B 12907841 1030953 We conclude that the lack of the gene for histamine H(1)R does not seem to be crucial for the ACTH and [CORT] *response* to , either due to possible functional compensation in the H(1)R knockout mouse or due to activation of pathways other than the neuronal histaminergic system . Regulation CP TNF 1377744 190536 The absolute increase in [ceruloplasmin] in *response* to was enhanced in rats fed the alanine supplemented diet relative to those fed the 20 % casein diet . Regulation CPOX ARSA 14633677 1170786 We examined in cultured human colon cancer cells the *effect* of on the beta-catenin/T-cell factor signaling pathway , nuclear factor-kappaB , and NO synthase 2 and on [cyclooxygenase (COX)] expression , all presumed to participate in colon carcinogenesis . Regulation CPOX IL1B 12171167 974141 To determine the *effects* of recombinant equine ( reIL-1beta ) and 4 anti-inflammatory compounds on the expression and activity of [cyclooxygenase (COX)-2] in cultured equine chondrocytes . Regulation CPOX IL1B 16556676 1562119 By contrast , with the existing known human endometrial cell lines Ishikawa and KLE , HIESC and HIEEC increase their production of PGF2alpha and PGE2 and [cyclooxygenase (COX)-2] protein expression in *response* to . Regulation CPOX IL1B 7505613 237682 In this study we have examined the effects of on both inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase ( iCOX ) expression , and the direct *effects* of nitric oxide on the activity of [COX] . Regulation CPOX TLR7 22235849 2591897 Induction of [cyclooxygenase (COX)-2] in human vaginal epithelial cells in *response* to ligands and TNF-a . Regulation CPOX TNF 22235849 2591896 Induction of [cyclooxygenase (COX)-2] in human vaginal epithelial cells in *response* to TLR ligands and . Regulation CPP EPHB2 18940233 1989100 However , the *roles* of in the morphine paired [conditioned place preference (CPP)] are not clear . Regulation CRAT EPHB2 11861527 917309 We conclude that and JNK are *involved* in basal and GnRH-A stimulation of [LHbeta-CAT] activity . Regulation CRAT IL1B 16867259 1592900 The inductive effect of WEHE on IL-1beta gene expression was further investigated by a chloramphenicol acetyltransferase (CAT) reporter gene assay using a transient transfection with pIL-1 ( 870 bp ) -CAT where the expression of the [CAT] gene was *regulated* by a promoter . Regulation CRAT KLF9 11751593 898576 By contrast , VP16/PR-B and had no *effect* on basal [CAT] activity . Regulation CRAT NR2F1 9704574 525576 Although both TR2 and TR4 showed no effect on CAT activity by itself , our data showed only the TR4 could crosstalk to the chicken ovalbumin upstream protein-transcription factor ( COUP-TF1 ) and thyroid hormone receptor ( TR alpha 1 ) , and potentiated the transcriptional activity of HIV-LTR on the [CAT] reporter gene *regulated* by and TR alpha 1 . Regulation CRAT NT5E 7505167 237565 The *effects* of BDNF and on [CAT] activity appeared to be synergistic with that of CNTF . Regulation CRAT TNF 7628389 316412 To determine whether TNF alpha inhibits the cAMP induced expression of the Cyp17 gene , plasmids containing two different size fragments of the 5'-flanking region of the Cyp17 gene upstream of the chloramphenicol acetyltransferase (CAT) reporter gene were transiently transfected into MA-10 tumor Leydig cells , and the *effect* of on cAMP induced [CAT] activity was determined . Regulation CREB1 EPHB2 15193999 1259710 These results suggest that FK960 stimulates GDNF production in c-Fos- and CREB dependent mechanisms in cultured astrocytes and that signal is *responsible* for both c-Fos expression and [CREB] phosphorylation in the cascades . Regulation CREB1 EPHB2 15265911 1275588 We also show that CREB is activated downstream of the pre-TCR complex , and that the induction of [CREB] activity is *regulated* by protein kinase C alpha- and mediated signals . Regulation CREB1 EPHB2 15383527 1334760 DNA precipitation assays and DNA decoy experiments indicated that *dependent* activation of [CREB] binding to a CRE/AP-1 like element ( designated `` CRE2 '' ) at the position of -413 largely contributed to the transcriptional effects of FSS . Regulation CREB1 EPHB2 16678346 1563500 Previously , we reported that N-acetyl-O-methyldopamine ( NAMDA ) protects neurons from ischemia via enhancing *dependent* [CREB] phosphorylation . Regulation CREB1 EPHB2 16678346 1563503 The effect was completely blocked by a specific MEK inhibitor U0126 , suggesting the involvement of *dependent* [CREB] signaling . Regulation CREB1 EPHB2 16854387 1600391 Short chain fatty acids induce TH gene expression via *dependent* phosphorylation of [CREB] protein . Regulation CREB1 EPHB2 17074386 1708963 We propose that ryanodine receptor stimulation by activity generated redox species produces calcium release signals that may contribute significantly to hippocampal synaptic plasticity , including plasticity that requires long lasting *dependent* [CREB] phosphorylation . Regulation CREB1 EPHB2 17082637 1643382 Our findings collectively indicate that signaling *plays* key roles in both Elk1 , [CREB] , and ATF-1 activation and the subsequent recruitment of c-Jun to the FRA-1 promoter in response to TNF-alpha in pulmonary epithelial cells . Regulation CREB1 EPHB2 18205034 1863865 Activation of PKA , PKC , and p38 MAPK is *involved* in preconditioning induced [CREB] phosphorylation . Regulation CREB1 EPHB2 18234163 1871300 These results suggest that antidepressants acutely increase [CREB] activity in PTK and *dependent* manners , which might contribute to gene expression including GDNF in glial cells . Regulation CREB1 IL1B 10965886 728054 The transcription factor [CREB] , a potential substrate of both protein kinase A (PKA) and RSK-1 , is phosphorylated in *response* to and cAMP in HepG2 cells . Regulation CREB1 MAP2K6 10406459 629423 This dominant *involvement* of in [CREB] transcriptional activation seems to be uncoupled from CREB Ser-133 phosphorylation . Regulation CREB1 MAP2K6 21448293 2412601 Here we describe a novel neuronal signaling pathway whereby CRF leads to a rapid Gß?- and *dependent* increase in [CREB] phosphorylation . Regulation CREB1 SPHK1 16313513 1486947 Moreover , [CREB] phosphorylation in response to NT-3 *involves* , the enzyme that synthesizes S1P . Regulation CREB1 TNF 16077166 1442292 did not *affect* levels of either CREB or [phospho-CREB] in whole cell lysates ; Regulation CREB1 TNF 17082637 1643381 Our findings collectively indicate that ERK signaling plays key roles in both Elk1 , [CREB] , and ATF-1 activation and the subsequent recruitment of c-Jun to the FRA-1 promoter in *response* to in pulmonary epithelial cells . Regulation CREB3 EPHB2 15193999 1259711 These results suggest that FK960 stimulates GDNF production in c-Fos- and CREB dependent mechanisms in cultured astrocytes and that signal is *responsible* for both c-Fos expression and [CREB] phosphorylation in the cascades . Regulation CREB3 EPHB2 15265911 1275603 We also show that CREB is activated downstream of the pre-TCR complex , and that the induction of [CREB] activity is *regulated* by protein kinase C alpha- and mediated signals . Regulation CREB3 EPHB2 15383527 1334761 DNA precipitation assays and DNA decoy experiments indicated that *dependent* activation of [CREB] binding to a CRE/AP-1 like element ( designated `` CRE2 '' ) at the position of -413 largely contributed to the transcriptional effects of FSS . Regulation CREB3 EPHB2 16678346 1563501 Previously , we reported that N-acetyl-O-methyldopamine ( NAMDA ) protects neurons from ischemia via enhancing *dependent* [CREB] phosphorylation . Regulation CREB3 EPHB2 16678346 1563504 The effect was completely blocked by a specific MEK inhibitor U0126 , suggesting the involvement of *dependent* [CREB] signaling . Regulation CREB3 EPHB2 16854387 1600392 Short chain fatty acids induce TH gene expression via *dependent* phosphorylation of [CREB] protein . Regulation CREB3 EPHB2 17074386 1708964 We propose that ryanodine receptor stimulation by activity generated redox species produces calcium release signals that may contribute significantly to hippocampal synaptic plasticity , including plasticity that requires long lasting *dependent* [CREB] phosphorylation . Regulation CREB3 EPHB2 17082637 1643384 Our findings collectively indicate that signaling *plays* key roles in both Elk1 , [CREB] , and ATF-1 activation and the subsequent recruitment of c-Jun to the FRA-1 promoter in response to TNF-alpha in pulmonary epithelial cells . Regulation CREB3 EPHB2 18205034 1863885 Activation of PKA , PKC , and p38 MAPK is *involved* in preconditioning induced [CREB] phosphorylation . Regulation CREB3 EPHB2 18234163 1871301 These results suggest that antidepressants acutely increase [CREB] activity in PTK and *dependent* manners , which might contribute to gene expression including GDNF in glial cells . Regulation CREB3 IL1B 10965886 728055 The transcription factor [CREB] , a potential substrate of both protein kinase A (PKA) and RSK-1 , is phosphorylated in *response* to and cAMP in HepG2 cells . Regulation CREB3 MAP2K6 10406459 629430 This dominant *involvement* of in [CREB] transcriptional activation seems to be uncoupled from CREB Ser-133 phosphorylation . Regulation CREB3 MAP2K6 21448293 2412608 Here we describe a novel neuronal signaling pathway whereby CRF leads to a rapid Gß?- and *dependent* increase in [CREB] phosphorylation . Regulation CREB3 SPHK1 16313513 1486949 Moreover , [CREB] phosphorylation in response to NT-3 *involves* , the enzyme that synthesizes S1P . Regulation CREB3 TNF 16077166 1442293 did not *affect* levels of either [CREB] or phospho-CREB in whole cell lysates ; Regulation CREB3 TNF 17082637 1643383 Our findings collectively indicate that ERK signaling plays key roles in both Elk1 , [CREB] , and ATF-1 activation and the subsequent recruitment of c-Jun to the FRA-1 promoter in *response* to in pulmonary epithelial cells . Regulation CREB5 EPHB2 15193999 1259709 These results suggest that FK960 stimulates GDNF production in c-Fos- and CREB dependent mechanisms in cultured astrocytes and that signal is *responsible* for both c-Fos expression and [CREB] phosphorylation in the cascades . Regulation CREB5 EPHB2 15265911 1275573 We also show that CREB is activated downstream of the pre-TCR complex , and that the induction of [CREB] activity is *regulated* by protein kinase C alpha- and mediated signals . Regulation CREB5 EPHB2 15383527 1334759 DNA precipitation assays and DNA decoy experiments indicated that *dependent* activation of [CREB] binding to a CRE/AP-1 like element ( designated `` CRE2 '' ) at the position of -413 largely contributed to the transcriptional effects of FSS . Regulation CREB5 EPHB2 16678346 1563499 Previously , we reported that N-acetyl-O-methyldopamine ( NAMDA ) protects neurons from ischemia via enhancing *dependent* [CREB] phosphorylation . Regulation CREB5 EPHB2 16678346 1563502 The effect was completely blocked by a specific MEK inhibitor U0126 , suggesting the involvement of *dependent* [CREB] signaling . Regulation CREB5 EPHB2 16854387 1600390 Short chain fatty acids induce TH gene expression via *dependent* phosphorylation of [CREB] protein . Regulation CREB5 EPHB2 17074386 1708962 We propose that ryanodine receptor stimulation by activity generated redox species produces calcium release signals that may contribute significantly to hippocampal synaptic plasticity , including plasticity that requires long lasting *dependent* [CREB] phosphorylation . Regulation CREB5 EPHB2 17082637 1643380 Our findings collectively indicate that signaling *plays* key roles in both Elk1 , [CREB] , and ATF-1 activation and the subsequent recruitment of c-Jun to the FRA-1 promoter in response to TNF-alpha in pulmonary epithelial cells . Regulation CREB5 EPHB2 18205034 1863845 Activation of PKA , PKC , and p38 MAPK is *involved* in preconditioning induced [CREB] phosphorylation . Regulation CREB5 EPHB2 18234163 1871299 These results suggest that antidepressants acutely increase [CREB] activity in PTK and *dependent* manners , which might contribute to gene expression including GDNF in glial cells . Regulation CREB5 IL1B 10965886 728053 The transcription factor [CREB] , a potential substrate of both protein kinase A (PKA) and RSK-1 , is phosphorylated in *response* to and cAMP in HepG2 cells . Regulation CREB5 MAP2K6 10406459 629416 This dominant *involvement* of in [CREB] transcriptional activation seems to be uncoupled from CREB Ser-133 phosphorylation . Regulation CREB5 MAP2K6 21448293 2412594 Here we describe a novel neuronal signaling pathway whereby CRF leads to a rapid Gß?- and *dependent* increase in [CREB] phosphorylation . Regulation CREB5 SPHK1 16313513 1486945 Moreover , [CREB] phosphorylation in response to NT-3 *involves* , the enzyme that synthesizes S1P . Regulation CREB5 TNF 16077166 1442291 did not *affect* levels of either [CREB] or phospho-CREB in whole cell lysates ; Regulation CREB5 TNF 17082637 1643379 Our findings collectively indicate that ERK signaling plays key roles in both Elk1 , [CREB] , and ATF-1 activation and the subsequent recruitment of c-Jun to the FRA-1 promoter in *response* to in pulmonary epithelial cells . Regulation CREBBP EPHB2 12824291 1113650 These results indicate that *dependent* [R-Smad] linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells . Regulation CREBBP EPHB2 19489936 2120506 We show that ORF3 mediated activation was *responsible* for the observed increase in phosphorylation and transactivation activity of [p300/CBP] . Regulation CRH IL1B 11058221 746189 The activation of neurosecretory neurons that express [corticotropin releasing hormone (CRH)] in *response* to increased circulating levels of depends on prostaglandin E ( 2 ) ( PGE ( 2 ) ) acting locally within the brain parenchyma . Regulation CRH IL1B 11244300 792298 We examined the role of nucleus tractus solitarius (NTS) and ventrolateral medulla ( VLM ) catecholamine cells in the activation of mPVN [CRH] , hypothalamic oxytocin ( OT ) and central amygdala cells in *response* to ( 1 microg/kg , i.a. ) . Regulation CRH IL1B 11244300 792301 Both VLM and NTS lesions reduced the mPVN [CRH] and OT cell *responses* to . Regulation CRH IL1B 12535154 1049271 is *involved* in hypothalamic regulation of [corticotropin releasing hormone (CRH)] secretion and consequent downstream modulation of the neuroimmune response . Regulation CRH IL1B 1517398 196851 Dexamethasone also blocked the [CRF] *response* to , indicating that activated glucocorticoid receptors can inhibit the response of CRF to IL-1 beta . Regulation CRH IL1B 15927699 1414205 is *involved* in hypothalamic regulation of the neuroimmune response by influencing the synthesis and secretion of [corticotropin releasing hormone (CRH)] , vasopressin ( VP ) and other stress related mediators . Regulation CRH IL1B 17318020 1699904 The aim of this study was to investigate the hypothesis that might be *involved* in the increase of the circulating levels of placental derived [CRH] leading to the initiation of pre-term labor . Regulation CRH IL1B 20004705 2199831 These results suggest that and NO are *involved* in NE-induced [CRH] release . Regulation CRH IL1B 20004705 2199833 In summary , the current study demonstrates that *plays* a significant role in NE-induced [CRH] release , and that neuroendocrine response in the PVN may depend on local NO action . Regulation CRH IL1B 7680697 211826 To test the utility of the assay , hypothalami were stimulated in vitro with , a putative *regulator* of [CRF] secretion , and CRF was measured in hypothalamic homogenates and conditioned media . Regulation CRH IL1B 8413817 233929 Adrenalectomy 7-14 days prior to autopsy increased significantly ( p < 0.01 ) the magnitude of the [CRF-41] *responses* to IL-1 alpha , and IL-6 but not to IL-8 . Regulation CRH IL1B 9688345 521959 *Effect* of endotoxin and on [corticotropin-releasing-factor] and prostaglandin release by rat brainstem slices . Regulation CRH IL1B 9688345 521960 This study investigated the *effects* of lipopolysaccharide (LPS) and on [corticotropin releasing factor (CRF)] and prostaglandin E2 ( PGE2 ) release by brainstem slices in vitro . Regulation CRH TNF 1460089 206635 Since NA released in the ME might be involved in the modulation of corticotropin releasing factor (CRF) production , it is suggested that , through presynaptic modulation of NA release from noradrenergic nerve terminals in the ME , might *regulate* [CRF] and other neurohormone release in this hypothalamic structure . Regulation CRH TNF 1846105 151533 Neither IL-2 ( 1-10000 U/ml ) , IL-8 ( 0.1-10 nM ) , ( 10-1000 U/ml ) , interferon-alpha 2 ( 10-1000 U/ml ) nor interferon-gamma ( 10-1000 U/ml ) had any *effect* on hypothalamic [CRH-41] release or pituitary ACTH release . Regulation CRH TNF 24553014 2886238 Induced [CRH] release *involves* IL-1 , IL-6 and , for stimulation adrenocorticotropic hormone ( ACTH ) release from the anterior pituitary . Regulation CRHR1 IL1B 17431005 1748954 In contrast , had no *effect* on [CRH-R1d] mRNA expression . Regulation CRHR2 IL1B 12045360 895162 In this study , we further explored the *regulation* of [CRF R2beta] mRNA levels by in the rat vascular smooth muscle A7r5 cells . Regulation CRIM1 EPHB2 25086356 2954018 These results demonstrate that CRIM1 is an early response gene in the presence of both angiogenic stimulation ( VEGF ) and environmental ( extracellular matrix ) factors , and and FAK might be *involved* in the upregulation of [CRIM1] mRNA expression in vascular endothelial cells . Regulation CRK EPHB2 15833106 1403934 By means of specific inhibitors we showed that [p38] and ERK act downstream of CD28 and that and JNK *act* downstream of ICOS leading to the induction of various T cell derived cytokines . Regulation CRK EPHB2 18322799 1886184 Hence , beta1 integrin/Fak/Src signaling translates into integrated mediating functions of [p38beta] activation and *regulation* of Bcl-2 homologs by PI3-K/Akt-1 and , consequently determining their requirement ( or not ) for survival . Regulation CRK EPHB2 18796294 1976167 In addition , TNFalpha induced p53 activation was reduced by or JNK inhibition , but it was not *affected* by [p38] inhibition . Regulation CRK EPHB2 24253595 2910475 We examined the *role* of in the regulation of MKP1 and JNK , and [p38] activities and apoptosis . Regulation CRK FAS 8972182 408511 In this study , crmA antagonized , and YVAD-CMK and Z-VAD-FMK completely inhibited , Fas activation of p38 kinase activity , demonstrating that *dependent* activation of [p38] requires ICE/CED-3 family members and conversely that the MKK3/p38 activation cascade represents a downstream target for the ICE/CED-3 family proteases . Regulation CRK IL1B 18313411 1897485 CO was found to increase p38 phosphorylation and [p38] inhibition using SB203580 increased iNOS protein levels in *response* to . Regulation CRK MAP2K6 18322799 1886191 Hence , beta1 integrin/Fak/Src signaling translates into integrated mediating functions of [p38beta] activation and *regulation* of Bcl-2 homologs by PI3-K/Akt-1 and , consequently determining their requirement ( or not ) for survival . Regulation CRK MAP2K6 21354263 2420610 p38ß induced BNP transcription was diminished by mutation of GATA-4 binding site , whereas overexpression of , an upstream *regulator* of [p38a] and p38ß , activated BNP transcription through both GATA-4 and AP-1 . Regulation CRK MAP2K6 24253595 2910481 We examined the *role* of in the regulation of MKP1 and JNK , and [p38] activities and apoptosis . Regulation CRK TNF 15897117 1408552 AOPP-BSA induced secretion in monocytes , and the intracellular signaling *involves* ROS produced by activated NADPH oxidase and subsequent [p38] phosphorylation . Regulation CRK TNF 20071450 2194129 Because the pathomechanism of TRAPS may involve aberrant TNF mediated intracellular signalling , we examined phosphorylation levels of nuclear factor kappaB (NF-kappaB) and [p38] in *response* to in 10 patients with three different TNFRSF1A mutations ( C73R , C88Y and F112I ) . Regulation CRK TNF 9559646 500215 Here , we have studied the *role* of several receptor associated proteins and caspases in [p38] MAPK activation by TNF . Regulation CRK TNFSF10 20406302 2293970 We further show that the *effects* of on DC maturation were not the result of the induction of apoptosis , but may involve [p38] activation . Regulation CRP IL1B 12667216 1075571 They raise the possibility , not as yet established , that NF-kappaB activation may be responsible for the synergistic *effect* of on IL-6 induced [CRP] expression . Regulation CRP IL1B 14656692 1177197 Our findings suggest that in healthy people , basal [CRP] levels are *regulated* by but not by IL6 genetics . Regulation CRS AXIN2 15790973 1386511 The *role* of in calvarial morphogenesis and [craniosynostosis] . Regulation CRTC1 MAP2K6 23903755 2822394 We found that suppression of [TORC1] activity in *response* to RAF or inhibitors , as measured by decreased phosphorylation of ribosomal protein S6 (P-S6) , effectively predicted induction of cell death by the inhibitor in BRAF-mutant melanoma cell lines . Regulation CRY1 TFPI2 16790549 1585801 We demonstrate that [cryptochrome] *regulates* clock protein phosphorylation by modulating the effect of on CKIepsilon . Regulation CRY2 TFPI2 16790549 1585803 We demonstrate that [cryptochrome] *regulates* clock protein phosphorylation by modulating the effect of on CKIepsilon . Regulation CRYAB SMN2 16129694 1474759 Co-immunoprecipitation experiments suggested that the import of [alphaB-crystallin] is possibly *regulated* by its phosphorylation dependent interaction with the , an important factor in small nuclear ribonucleoprotein nuclear import and assembly . Regulation CSDE1 IL1B 19454352 2084489 The known fungal pattern recognition receptors TLR2 and Dectin-1 regulate IL-1beta gene transcription , whereas the NLRP3 containing proinflammatory [multiprotein complex] , the NLRP3 inflammasome , *controls* caspase-1 mediated cleavage of . Regulation CSE ARSA 16230075 1470027 These data establish a physiologic role for H ( 2 ) S in regulating the gastric microcirculation and identify [CSE] as a novel *target* for . Regulation CSE CAPN8 15180919 1288684 These results suggest that [CSE] attenuates angiogenesis of PAEC and the mechanism *involves* inhibition of . Regulation CSF1 IL1B 20204061 2181001 Therefore , we examined the effect of IL-1beta and/or celecoxib on the expression of macrophage colony stimulating factor ( [M-CSF] ) , receptor activator of NF-kappaB ligand ( RANKL ) , and osteoprotegerin (OPG) in human chondrocytes , and the indirect *effect* of on osteoclast-like cell formation using RAW264.7 cells . Regulation CSF1 IL1B 8445029 213750 Since IL-1 beta stimulates CSF-1 production in a variety of mesenchymal cell types including second trimester villous core mesenchymal cells , the present study was designed to determine if could also *regulate* [CSF-1] production in term placental explants in vitro . Regulation CSF1 IL1B 8445029 213752 These results demonstrate that IL-1 beta can regulate placental CSF-1 production in vitro and suggest that maternal decidual may *regulate* placental [CSF-1] production in vivo . Regulation CSF1 SELL 20925194 2332413 In our previous studies , we reported that ligation could *regulate* [CSF-1] ( colony stimulating factor-1 ) gene transcription , in which AP-1 acts as a crucial transcriptional factor . Regulation CSF1 TNF 15274652 1276723 Our data indicated that [M-CSF] and MCP-1 were *regulated* by IL-1alpha and . Regulation CSF1 TNF 1623556 191523 Production of macrophage colony stimulating factor ( [M-CSF] ) by human monocytes is differentially *regulated* by GM-CSF , , and IFN-gamma . Regulation CSF1 TNF 16734568 1566217 Because osteoclastogenesis requires the presence of macrophage colony stimulating factor ( M-CSF ) , we examined whether HPDL cells secrete [M-CSF] in *response* to . Regulation CSF1 TNF 2105339 126983 The *effects* of on the regulation of macrophage-specific colony stimulating factor ( [CSF-1] ) gene expression have been studied in HL-60 cells during monocytic differentiation . Regulation CSF1 TNF 8347686 227017 A specific radioimmunoassay was employed to demonstrate that human articular cartilage and chondrocyte monolayers in organ and cell culture , respectively , produce macrophage colony stimulating factor ( [M-CSF] ) in *response* to stimulation with interleukin-1 alpha (IL-1 alpha) , IL-1 beta , and TNF beta . Regulation CSF1 TNF 8347686 227025 Low levels of M-CSF were observed in the supernatants of nonstimulated cultures while increased levels of [M-CSF] in *response* to IL-1 alpha and were detected following 2 h exposure to the cytokines . Regulation CSF1 TNF 8347686 227029 We propose that chondrocyte [M-CSF] production in *response* to IL-1 and , and the concurrent destruction of cartilage by these cytokines , could provide a mechanism for the chronic nature of rheumatoid disease . Regulation CSF1 TNF 8382248 212099 *Regulation* of monocyte chemoattractant protein-1 and [macrophage colony stimulating factor-1] by IFN-gamma , , IgG aggregates , and cAMP in mouse mesangial cells . Regulation CSF1 TNF 8647916 366332 Because colony stimulating factor-1 (CSF-1) is essential for osteoclast progenitor proliferation , we examined the *effect* of on osteoblast expression of [CSF-1] . Regulation CSF1 TNF 8781564 380386 In this study , we examined the *effect* of on mesangial cell gene expression of [M-CSF] , a colony stimulating factor associated with monocyte differentiation into macrophages and proliferation . Regulation CSF1R TNF 19628784 2137867 [c-Fms] expression in HSCs/promonocytes was mainly *regulated* by derived from BM CD45 ( - ) CD34 ( - ) stromal cells , and Ang II specifically regulated the TNF-alpha synthesis and release from BM stromal cells . Regulation CSF2 EPHB2 11520738 852318 [GM-CSF] release is p42/p44 *dependent* and is tonically suppressed by a mechanism that is partially dependent on p38 MAP kinase , though direct inhibition of cyclooxygenase (COX) activity due to poor inhibitor selectivity may also contribute . Regulation CSF2 EPHB2 18056041 1833412 signaling *regulates* macrophage [colony stimulating factor] expression induced by titanium particles in MC3T3.E1 murine calvarial preosteoblastic cells . Regulation CSF2 EPHB2 9533450 496956 However , the production of IL-3 and IL-4 was only partially dependent upon ERK activation , whereas IL-5 , IL-10 , IFN-gamma and [GM-CSF] production was severely *affected* by diminished activation . Regulation CSF2 IL1B 10783130 688162 Molecular *regulation* of granulocyte macrophage [colony stimulating factor] in human lung epithelial cells by , IL-4 , and IL-13 involves both transcriptional and post-transcriptional mechanisms . Regulation CSF2 IL1B 11446745 835419 *Regulation* of granulocyte-macrophage [colony stimulating factor] in human retinal pigment epithelial cells by and IFN-gamma . Regulation CSF2 IL1B 11956032 930886 The *effect* of and tumor necrosis factor-alpha (TNF-alpha) on granulocyte [macrophage-colony stimulating factor] ( GM-CSF ) production by neuronal precursor cells . Regulation CSF2 IL1B 11956032 930890 To determine whether granulocyte [macrophage-colony stimulating factor] ( GM-CSF ) production by neuronal precursor ( NT2 ) cells can be *regulated* by and TNF-alpha . Regulation CSF2 IL1B 11956032 930892 The *effect* of and TNF-alpha on [GM-CSF] production was assessed by dose response ( 0 to 2,000 U/ml ) , and time course ( 0 to 48 hours incubation ) experiments . Regulation CSF2 IL1B 15699160 1372504 *dependent* release of eotaxin , RANTES , and [GM-CSF] was enhanced by fibronectin and by fibrillar and monomeric type I collagen , with similar changes in mRNA abundance . Regulation CSF2 IL1B 1690240 128410 We examined the *effects* of IL-1 alpha and on the production of G-CSF and [GM-CSF] by U87MG and U373MG , another astroglial tumor cell line that does not constitutively produce CSF . Regulation CSF2 IL1B 20204061 2181002 Therefore , we examined the effect of IL-1beta and/or celecoxib on the expression of macrophage [colony stimulating factor] ( M-CSF ) , receptor activator of NF-kappaB ligand ( RANKL ) , and osteoprotegerin (OPG) in human chondrocytes , and the indirect *effect* of on osteoclast-like cell formation using RAW264.7 cells . Regulation CSF2 IL1B 2476327 116972 The expression of granulocyte-macrophage [colony stimulating factor] ( GM-CSF ) and granulocyte colony stimulating factor ( G-CSF ) genes by stromal cells of the hematopoietic microenvironment is *regulated* , in vitro , by interleukin 1 alpha (IL-1 alpha) and . Regulation CSF2 IL1B 8600166 351806 Both cell lines produce interleukin (IL)-1 beta , granulocyte colony stimulating factor ( G-CSF ) and [granulocyte-macrophage CSF (GM-CSF)] , but neither , G-CSF , their corresponding antibodies and inhibitory molecules , nor GM-CSF , *affected* the cell lines ' growth . Regulation CSF2 IL1B 8707349 371192 Production of granulocyte-macrophage [colony stimulating factor] by T cells is *regulated* by B7 and . Regulation CSF2 IL1B 8928904 366090 Neither heat inactivated nor IL-1 beta vehicle *affected* arteriolar diameter or [CSF] levels of prostanoids . Regulation CSF2 IL1B 9038318 415452 Involvement of mannose receptor in cytokine , IL-6 , and granulocyte-macrophage [colony stimulating factor] *responses* , but not in chemokine macrophage inflammatory protein 1beta ( MIP-1beta ) , MIP-2 , and KC responses , caused by attachment of Candida albicans to macrophages . Regulation CSF2 IL1B 9832332 551723 Finally , disruption of either microtubules ( with colchicine ) or microfilaments ( with cytochalasin B ) resulted in reduced [GMCSF] mRNA expression in *response* to . Regulation CSF2 IL6R 10671302 666722 The objective of this study was to investigate the pathophysiological *roles* of soluble ( sIL-6R ) in [cerebrospinal fluid (CSF)] . Regulation CSF2 TCN1 14971031 1209302 Dendritic cells generated in the presence of [GM-CSF] plus IL-15 prime potent CD8+ *responses* in vivo . Regulation CSF2 TNF 10199558 605265 Role of NFkappaB in the *regulation* of macrophage [colony stimulating factor] by in ST2 bone stromal cells . Regulation CSF2 TNF 11956032 930885 The *effect* of interleukin-1beta (IL-1beta) and on granulocyte [macrophage-colony stimulating factor] ( GM-CSF ) production by neuronal precursor cells . Regulation CSF2 TNF 11956032 930889 To determine whether granulocyte [macrophage-colony stimulating factor] ( GM-CSF ) production by neuronal precursor ( NT2 ) cells can be *regulated* by IL-1beta and . Regulation CSF2 TNF 11956032 930891 The *effect* of IL-1beta and on [GM-CSF] production was assessed by dose response ( 0 to 2,000 U/ml ) , and time course ( 0 to 48 hours incubation ) experiments . Regulation CSF2 TNF 14980510 1213970 IL-6 , LIF , and *regulation* of [GM-CSF] inhibition of osteoclastogenesis in vitro . Regulation CSF2 TNF 15723090 1396083 Similarly , IKK beta ( KA ) and I kappa B alpha delta N overexpression also inhibited IL-1beta- and *dependent* increases in ICAM-1 , IL-8 and [GM-CSF] in addition to IL-1beta mediated increases in cyclooxygenase-2 expression , whereas IKK alpha ( KM ) overexpression had little effect on these outputs . Regulation CSF2 TNF 1623556 191526 Production of macrophage [colony stimulating factor] ( M-CSF ) by human monocytes is differentially *regulated* by GM-CSF , , and IFN-gamma . Regulation CSF2 TNF 16522458 1531299 The capacity of IL-17E to enhance [GM-CSF] and CXCL-8 *responses* to was accompanied by production and secretion of both proteins by lung fibroblasts . Regulation CSF2 TNF 16734568 1566215 Human periodontal ligament cells secrete macrophage [colony stimulating factor] in *response* to in vitro . Regulation CSF2 TNF 1705566 152965 The *effect* does not occur at 0 degrees C and can not be induced by IL-2 , IL-6 , or [GM-CSF] . Regulation CSF2 TNF 1709645 158030 In the present study , we examined the *effects* of on the production of [GM-CSF] and G-CSF by U87MG , a human astroglial cell line that constitutively expresses GM-CSF and G-CSF , and U373MG , a second human astroglial cell line that does not produce CSF . Regulation CSF2 TNF 1714478 163511 Results obtained by Northern analysis of chondrocyte total RNA reflected those found for the CSF Ag , namely that [CSF] mRNA levels were elevated in *response* to IL-1 , but not , and that there was synergy between these two cytokines . Regulation CSF2 TNF 1825289 153230 We have analyzed the *effects* of on the expression of [GM-CSF] and IL-3 receptors on AML cells . Regulation CSF2 TNF 19180992 2007115 Treatment of NECs with EP at more than 25 ng/ml , reduced the ability of NECs to produce [GM-CSF] in *response* to stimulation . Regulation CSF2 TNF 19850966 2170297 ET-1 and granulocyte-macrophage colony stimulating factor ( [GM-CSF] ) expression in *response* to and ET-1 stimulation was investigated , and the impact of mitogen activated protein kinase (MAPK) pathways in this context was studied . Regulation CSF2 TNF 2026869 157460 VI. Analysis of the synovial cells involved in granulocyte-macrophage [colony stimulating factor] production and gene expression in rheumatoid arthritis and its *regulation* by IL-1 and . Regulation CSF2 TNF 2026869 157464 IL-1 and had a synergistic *effect* on [GM-CSF] production . Regulation CSF2 TNF 2105339 126982 Transcriptional and posttranscriptional *regulation* of macrophage-specific [colony stimulating factor] gene expression by . Regulation CSF2 TNF 2105339 126984 The *effects* of on the regulation of macrophage-specific [colony stimulating factor] ( CSF-1 ) gene expression have been studied in HL-60 cells during monocytic differentiation . Regulation CSF2 TNF 2504305 115256 Mesenchymal cells produce abundant [GM-CSF] in *response* to . Regulation CSF2 TNF 8062890 268721 More sensitive experiments using a luciferase reporter vector containing the GM-CSF promoter region were necessary to convincingly establish the *role* of and 8BrcAMP on transcriptional induction of the [GM-CSF] gene in +/+ ( - ) 1.LDA11 stromal cells . Regulation CSF2 TNF 8299733 248565 Depletion of potential accessory cells resulted in a marked stimulatory *response* of CB cells to , in the presence of [GM-CSF] , while it did not alter the responses to IFN . Regulation CSF2 TNF 8347686 227020 A specific radioimmunoassay was employed to demonstrate that human articular cartilage and chondrocyte monolayers in organ and cell culture , respectively , produce macrophage [colony stimulating factor] ( M-CSF ) in *response* to stimulation with interleukin-1 alpha (IL-1 alpha) , IL-1 beta , and TNF beta . Regulation CSF2 TNF 9122614 423989 The authors examined the regulatory *effects* of on granulocyte macrophage [colony stimulating factor] ( GM-CSF ) - , interleukin-3 (IL-3)- or macrophage colony stimulating factor ( M-CSF ) -induced gene expression of the low affinity receptor for IgE ( Fc epsilon RII ) on human monocytes and GM-CSF- , IL-3- or M-CSF induced soluble Fc epsilon RII ( sFc epsilon RII ) release from monocytes . Regulation CSF2 TNF 9187959 437082 GM-CSF production by EC was also stimulated by the combined effects of PAF and , but PAF alone did not *affect* [GM-CSF] production . Regulation CSF2 TNF 9742856 532308 In the early phases , , IL-beta and [GM-CSF] secreted by alveolar macrophages *regulate* and enhance pulmonary inflammation . Regulation CSF2RB TNF 7545455 318549 The *effects* of on [IL-3R] mRNA expression were completely different in a primitive and in a more committed hematopoietic cell line . Regulation CSF3 CAPN8 18524991 1952033 Thus , neutrophil apoptosis is *controlled* by [G-CSF] after initial activation of caspase-8 and mitochondrial permeabilization by the control of postmitochondrial activity . Regulation CSF3 EPHB2 15671148 1366087 *Roles* of Stat3 and in [G-CSF] signaling . Regulation CSF3 IL1B 10029158 591528 In the present study the *roles* of and TNF-alpha in DDTC mediated [G-CSF] induction were examined using human long-term bone marrow cultures ( hLTBMCs ) . Regulation CSF3 IL1B 1690240 128412 We examined the *effects* of IL-1 alpha and on the production of [G-CSF] and GM-CSF by U87MG and U373MG , another astroglial tumor cell line that does not constitutively produce CSF . Regulation CSF3 IL1B 2476327 116974 The expression of granulocyte-macrophage colony stimulating factor ( GM-CSF ) and [granulocyte colony stimulating factor] ( G-CSF ) genes by stromal cells of the hematopoietic microenvironment is *regulated* , in vitro , by interleukin 1 alpha (IL-1 alpha) and . Regulation CSF3 IL1B 8600166 351808 Both cell lines produce interleukin (IL)-1 beta , [granulocyte colony stimulating factor] ( G-CSF ) and granulocyte-macrophage CSF (GM-CSF) , but neither , G-CSF , their corresponding antibodies and inhibitory molecules , nor GM-CSF , *affected* the cell lines ' growth . Regulation CSF3 IL1B 8796827 381297 To test the hypothesis that and tumor necrosis factor-alpha (TNF-alpha) *regulate* [granulocyte colony stimulating factor] ( G-CSF ) production by human placental villous core mesenchymal cells . Regulation CSF3 ITGB2 12734371 1087325 Our data suggest regulatory *effects* of on [G-CSF] and IL-17 secretion , and as a corollary on neutrophilia . Regulation CSF3 PLAU 15494432 1366995 We investigated the *involvement* of the receptor ( uPAR ) in [granulocyte-colony stimulating factor] ( G-CSF ) -induced mobilization of CD34+ hematopoietic stem cells ( HSCs ) from 16 healthy donors . Regulation CSF3 TLR7 24518205 2955901 These data suggest that low-level TLR agonist production by commensal flora contributes to the regulation of HSC function and that [G-CSF] negatively *regulates* HSCs , in part , by enhancing signaling . Regulation CSF3 TNF 10029158 591527 In the present study the *roles* of IL-1beta and in DDTC mediated [G-CSF] induction were examined using human long-term bone marrow cultures ( hLTBMCs ) . Regulation CSF3 TNF 1709645 158031 In the present study , we examined the *effects* of on the production of GM-CSF and [G-CSF] by U87MG , a human astroglial cell line that constitutively expresses GM-CSF and G-CSF , and U373MG , a second human astroglial cell line that does not produce CSF . Regulation CSF3 TNF 8796827 381296 To test the hypothesis that interleukin-1 beta (IL-1 beta) and *regulate* [granulocyte colony stimulating factor] ( G-CSF ) production by human placental villous core mesenchymal cells . Regulation CSF3 TNF 9755100 535338 The release of [G-CSF] in *response* to , LPS , and BK was significantly increased . Regulation CSF3R TNF 10729720 678246 We determined protein and mRNA expression of G-CSF receptor in freshly isolated neutrophils from cord blood of healthy term newborns ( n = 16 ) and of adults ( n = 6 ) as well as the in vitro *effect* of supplemented recombinant human G-CSF ( rhG-CSF ) and on [G-CSF receptor] expression of neutrophils . Regulation CSF3R TNF 1705566 152968 TNF probably exerts its effect through activation of protein kinase C ( PKC ) as the *effect* on [G-CSF receptor] levels can be mimicked by 12-O-tetradecanoylphorbol-13- acetate . Regulation CSN2 ARSA 3588660 74098 Sodium cromoglycate ( 10 mg/kg ) selectively reduced the increases in [CSN] *response* to and IND. Phentolamine ( 0.2 mg/kg ) inhibited the increased CSN activity induced by ASA , IND , and TZ . Regulation CSN2 EDN2 10854619 704292 The present study evaluated the *effects* of peptides on [carotid sinus nerve (CSN)] activity , catecholamine ( CA ) release , and second messenger signaling pathways in rabbit carotid bodies superfused in vitro , and in dissociated chemosensory type I cells . Regulation CSN2 TGM2 6138286 31200 *Effects* of or phospholipase A2 inhibitors on down-regulation of prolactin receptors and stimulation of [casein] and DNA synthesis in mammary gland explants . Regulation CSN3 ARSA 3588660 74097 Sodium cromoglycate ( 10 mg/kg ) selectively reduced the increases in [CSN] *response* to and IND. Phentolamine ( 0.2 mg/kg ) inhibited the increased CSN activity induced by ASA , IND , and TZ . Regulation CSN3 EDN2 10854619 704289 The present study evaluated the *effects* of peptides on [carotid sinus nerve (CSN)] activity , catecholamine ( CA ) release , and second messenger signaling pathways in rabbit carotid bodies superfused in vitro , and in dissociated chemosensory type I cells . Regulation CSN3 TGM2 6138286 31192 *Effects* of or phospholipase A2 inhibitors on down-regulation of prolactin receptors and stimulation of [casein] and DNA synthesis in mammary gland explants . Regulation CSNK1E TFPI2 16790549 1585800 Here we show that protein *regulates* the kinase activity of [CKIepsilon] . Regulation CSNK1E TFPI2 16790549 1585805 We demonstrate that cryptochrome regulates clock protein phosphorylation by modulating the *effect* of on [CKIepsilon] . Regulation CSRP1 IL1B 20538278 2308238 and anti-IL-6 neutralizing antibodies did not *affect* AngII induced [CRP] expression . Regulation CSRP1 IL1B 7646436 318821 In kinetic studies of the endogenous CRP gene , alone had no *effect* on [CRP] mRNA levels , but when added to IL-6 , synergistically enhanced both CRP mRNA levels and transcription , as determined by Northern-blot analyses and nuclear run-on studies . Regulation CSRP1 IL1B 7646436 318822 These findings indicate that the *effect* of on [CRP] expression is exerted largely at the transcriptional level in this system . Regulation CSRP1 TNF 1651357 163083 alone had no significant *effect* on synthesis of either SAA or [CRP] , but the combination of IL-6 plus TNF-alpha led to substantial induction of SAA . Regulation CSRP1 TNF 7743670 306088 Since previous studies on the contributions of cytokine inhibitors in connective tissues diseases suggested that IL-1 and might *play* an important role in the regulation of [CRP] , we decided to examine in more detail the respective roles of IL-1 beta , IL-6 , and TNF-alpha and their inhibitors in the production of APP by human primary hepatocytes versus the hepatoma cell line PLC/PRF/5 . Regulation CST4 CST6 10454593 638091 Based on the pattern of genomic instability , inter-action with checkpoint mutations and sensitivity to chromosome replication or segregation inhibitors , we conclude that overexpression of [CST4] specifically interferes with mitotic chromosome segregation , and *affects* some aspect of DNA metabolism . Regulation CST6 ADRB1 1685882 175335 The findings suggest that the induction of salivary [cystatin] is *regulated* , in part , by stimulation . Regulation CST6 CST4 10454593 638092 Based on the pattern of genomic instability , inter-action with checkpoint mutations and sensitivity to chromosome replication or segregation inhibitors , we conclude that overexpression of specifically interferes with mitotic chromosome segregation , and [CST6] *affects* some aspect of DNA metabolism . Regulation CST6 CTSL 19262604 2072719 [Cystatin M/E] directly *controls* the activity of cathepsin V , , and legumain , thereby regulating the processing of transglutaminases . Regulation CST6 CTSV 19262604 2072720 [Cystatin M/E] directly *controls* the activity of , cathepsin L , and legumain , thereby regulating the processing of transglutaminases . Regulation CST6 CTSV 20495178 2319863 Biochemical evidence suggests that [cystatin M/E] *controls* the activity of legumain , cathepsin L , , and transglutaminase-3 . Regulation CST6 LGMN 19262604 2072721 [Cystatin M/E] directly *controls* the activity of cathepsin V , cathepsin L , and , thereby regulating the processing of transglutaminases . Regulation CST6 LGMN 20495178 2319864 Biochemical evidence suggests that [cystatin M/E] *controls* the activity of , cathepsin L , cathepsin V , and transglutaminase-3 . Regulation CST6 SDS 11479377 843580 It is , therefore , evident that an *dependent* conformational change of the protease itself , rather than the release of [cystatin] from the complex , is crucial for the activation . Regulation CST6 TGM3 20495178 2319862 Biochemical evidence suggests that [cystatin M/E] *controls* the activity of legumain , cathepsin L , cathepsin V , and . Regulation CSTA EPHB2 11451947 860121 These results indicate that the expression of [cystatin A] is *regulated* via mitogen activated protein kinase pathways positively by Ras/MEKK1/MKK7/JNK and negatively by . Regulation CTBP1 AXIN2 12711682 1083401 HMG box transcription factor TCF-4 's interaction with [CtBP1] *controls* the expression of the Wnt target in human embryonic kidney cells . Regulation CTCF PCDH19 22854024 2660643 Our results indicate that [CTCF] *regulates* functional neural development and neuronal diversity by controlling clustered expression . Regulation CTCF PCDH8 22854024 2660648 Our results indicate that [CTCF] *regulates* functional neural development and neuronal diversity by controlling clustered expression . Regulation CTF1 EDN2 11834704 911115 [Cardiotrophin-1] stimulation of cardiac fibroblast growth : *roles* for glycoprotein 130/leukemia inhibitory factor receptor and the type A receptor . Regulation CTF1 TNF 8939900 398547 Furthermore , TNF-alpha is unable to repress CTF-1 activity in NIH3T3 cells overexpressing ras or raf , suggesting that *regulates* [CTF-1] by a Ras-Raf kinase dependent pathway . Regulation CTGF AHSA1 15780081 1385204 Inhibition of ( mapk ) or p42/44(mapk) activities did not *affect* LDL induced TGF-beta1 , [CTGF] , and collagen I expression , whereas inhibition of c-Jun NH2-terminal kinase (JNK) suppressed LDL induced TGF-beta , CTGF , and collagen I expression . Regulation CTGF AKT1 12218048 1012117 The *role* of p42/44 MAPK and in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Regulation CTGF AKT1 19390991 2082024 Cell type-specific *regulation* of [CCN2] protein expression by signaling . Regulation CTGF AKT1 20201953 2259327 As previous studies showed that CCN2 can be a positive regulator of MMP1 , we examined the *effects* of inhibition on [CCN2] expression . Regulation CTGF AKT2 19390991 2082025 Cell type-specific *regulation* of [CCN2] protein expression by signaling . Regulation CTGF AKT2 20201953 2259328 As previous studies showed that CCN2 can be a positive regulator of MMP1 , we examined the *effects* of inhibition on [CCN2] expression . Regulation CTGF AKT3 19390991 2082026 Cell type-specific *regulation* of [CCN2] protein expression by signaling . Regulation CTGF AKT3 20201953 2259329 As previous studies showed that CCN2 can be a positive regulator of MMP1 , we examined the *effects* of inhibition on [CCN2] expression . Regulation CTGF ANGPT2 17074304 1675199 In growth arrested VSMCs , rosiglitazone attenuated the proliferation and apoptosis , increased PPAR-gamma production and activation , and reduced [CTGF] and ECM production in *response* to in a dose dependent fashion . Regulation CTGF ANGPT2 17592071 1768143 In these cells *regulated* [CTGF] via RhoA/Rho kinase activation , as shown by inhibition of Rho with C3 exoenzyme , RhoA dominant negative overexpression , and Rho kinase inhibition . Regulation CTGF APOB 15780081 1385171 The *effects* of on [CTGF] and collagen I expression were carried out in rat mesangial cells . Regulation CTGF APOB 16272194 1532195 To explore the mechanisms by which *regulates* [CTGF] and collagen IV expression in HAECs , we determined first if CTGF and collagen IV are downstream targets for regulation by transforming growth factor-beta ( TGF-beta ) . Regulation CTGF APOB 16272194 1532197 To assess whether the induction of [CTGF] in *response* to is mediated via autocrine activation of TGF-beta , HAECs were treated with LDL for 24 h in the presence and absence of anti-TGF-beta neutralizing antibodies ( anti-TGF-beta NA ) . Regulation CTGF APOB 16272194 1532200 To investigate the upstream mediators of TGF-beta on activity of [CTGF] in *response* to , HAECs were treated with LDL for 24 h in the presence and absence of cell-permeable MAPK inhibitors . Regulation CTGF APOB 22422617 2588069 Here , we have studied the mechanism by which *regulates* [CTGF] expression in renal mesangial cells . Regulation CTGF APOB 22422617 2588084 Our data suggest that SK1 dependent S1P receptor transactivation is upstream of ERK1/2 and JNK and that all three steps are required for *regulated* expression of [CTGF] in mesangial cells . Regulation CTGF BMP2 19038999 2023124 These findings suggest that [CCN2] may *regulate* the proliferating and differentiation of chondrocytes by forming a complex with as a novel modulator of BMP signalling . Regulation CTGF BMP7 19450457 2084404 Following combined BMP7/TGF-beta2 treatment , the antagonizing *effect* of on TGF-beta2 induced [CTGF] expression was abolished . Regulation CTGF BMP7 22099397 2585508 However , although siRNA mediated knock down of Alk2/3 or Smad1/5 counteracts the *effect* on basal [CTGF] expression there was no consistent reversion of the observed BMP-7 effect on TGF-ß1 mediated CTGF expression . Regulation CTGF CAV1 22277251 2642807 This study was undertaken to evaluate the *role* of in Smad1 signaling and [CCN2] expression in healthy and SSc dermal fibroblasts . Regulation CTGF CCND1 21928352 2524990 In the present study , we investigated whether [CCN2] *regulated* rat PASMCs ( rPASMCs ) proliferation induced by cigarette smoke extract (CSE) and nicotine by upregulating in vitro . Regulation CTGF CISH 18462443 1927301 Our results indicate that the clinical *effects* of <9-cis-RA> on SSc are , at least in part , attributable to the induction of PGE ( 2 ) and the subsequent suppression of [CTGF] expression that results in the blockade of collagenogenesis . Regulation CTGF CKAP4 22438586 2594521 In addition , we demonstrate that CKAP4 translocates to the nucleus and binds to the CCN2 proximal promoter in an APF dependent manner , providing evidence that [CCN2] regulation by APF *involves* nuclear translocation and binding to the CCN2 promoter . Regulation CTGF CRK 16272194 1532216 Inhibition of ( mapk ) activities did not *affect* LDL induced TGF-beta1 , [CTGF] , and collagen IV expression . Regulation CTGF CRK 17592071 1768172 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Regulation CTGF CSF1 19594046 2105403 The expression of CTGF and M-CSF protein is up regulated in osteoarthritis chondrocytes , which suggests that the activation of is *involved* in the production of [CTGF] . Regulation CTGF EDN1 15976312 1434722 Our aim was to investigate whether could *regulate* [CTGF] and to investigate the potential role of ET-1 in vascular fibrosis . Regulation CTGF EGF 12787426 1097011 In contrast , platelet derived growth factor ( PDGF ) , , and tumor necrosis factor-alpha (TNF-alpha) had no measurable *effects* on [CTGF] mRNA expression . Regulation CTGF EMD 18052711 1833281 This study explored the *effects* of on [CTGF] expression in human osteoblastic cells and whether the interaction is modulated by the TGF-beta signaling pathway . Regulation CTGF ENG 15319534 1286453 These results demonstrate that expression negatively *regulates* basal and TGF-beta1 induced [CTGF] and collagen expression and synthesis . Regulation CTGF EPHB2 17786299 1790892 Whereas p38 mediated CTGF induction by TGFbeta in fibroblasts , signaling mediated TGFbeta induced CTGF expression in pancreatic cancer cells and was also *responsible* for basal [CTGF] expression in pancreatic cancer cell lines with defective Smad signaling . Regulation CTGF EPHB2 21865737 2473487 Inhibition of p38 MAP kinase or activation did not *affect* cyclic stretch induced [CTGF] expression . Regulation CTGF EPHB2 24090133 2867553 Tumour cells down-regulate [CCN2] gene expression in co-cultured fibroblasts in a Smad7- and *dependent* manner . Regulation CTGF EPHB2 24275091 2893158 Dual inhibition of Src family kinases and Aurora kinases by SU6656 modulates [CTGF] ( connective tissue growth factor ) expression in an *dependent* manner . Regulation CTGF EPHB2 24275091 2893160 As ZM447439 increased ERK activity only after 48h , cellular reorganization is likely responsible for triggering the *dependent* upregulation of [CTGF] . Regulation CTGF ETS1 16469114 1573955 The induction of [CCN2] by TGFbeta1 *involves* . Regulation CTGF ETS1 22539964 2590244 In this study , we investigated the *role* of for [CCN2] induction by TGF-ß1 in primary osteoblasts . Regulation CTGF FGF2 21914781 2497178 These findings suggest that [CCN2] may *regulate* the proliferation and matrix degradation of chondrocytes by forming a complex with as a novel modulator of FGF2 functions . Regulation CTGF FOXO1 19390991 2082022 Cell type-specific *regulation* of [CCN2] protein expression by signaling . Regulation CTGF FOXO3 19390991 2082023 Cell type-specific *regulation* of [CCN2] protein expression by signaling . Regulation CTGF FOXO4 19390991 2082027 Cell type-specific *regulation* of [CCN2] protein expression by signaling . Regulation CTGF FOXO6 19390991 2082021 Cell type-specific *regulation* of [CCN2] protein expression by signaling . Regulation CTGF GNRH1 16697947 1560436 This study focuses on the *effects* of and tibolone on TGF-beta3 and [CTGF] expression in myometrium and myomas and supports the hypothesis of a pathogenetic role of these growth factors in uterine fibromatosis . Regulation CTGF HDAC1 20141616 2178982 Therefore , we hypothesized that , which modulate the accessibility of transcriptionally active promoter regions , might *play* a role in the regulation of [CTGF] gene expression . Regulation CTGF HDAC1 20141616 2178986 Taken together , our data indicate that the *effect* of inhibitors on [CTGF] expression is largely cell dependent in non-tumour cells . Regulation CTGF HDAC2 20141616 2178983 Therefore , we hypothesized that , which modulate the accessibility of transcriptionally active promoter regions , might *play* a role in the regulation of [CTGF] gene expression . Regulation CTGF HDAC2 20141616 2178987 Taken together , our data indicate that the *effect* of inhibitors on [CTGF] expression is largely cell dependent in non-tumour cells . Regulation CTGF HGF 17599773 1774594 Pretreatment of lung fibroblasts with neutralizing anti-c-Met antibody abolished the *effects* of on [CTGF] expression and collagen accumulation , suggesting that the antifibrotic activity of HGF is mediated via c-Met receptor tyrosine kinase . Regulation CTGF HGF 18829614 2034585 *Regulation* of [connective tissue growth factor (CTGF)] by in human tubular epithelial cells . Regulation CTGF IFI44 10976101 751902 In contrast to the induction of other early response genes ( Egr-1 and cyclooxygenase-2 ) , LPA mediated induction of [CTGF] was pertussis toxin-insensitive and *independent* of MAP kinase activation . Regulation CTGF IFNG 17116388 1700608 Inhibitory effects of on activation of rat pancreatic stellate cells are mediated by STAT1 and *involve* down-regulation of [CTGF] expression . Regulation CTGF IFNG 17376761 1766031 TNF-alpha , but not , *regulates* [CCN2] ( CTGF ) , collagen type I , and proliferation in mesangial cells : possible roles in the progression of renal fibrosis . Regulation CTGF IL1A 23454256 2776319 Signaling pathway inhibitor studies suggested an important role for the p38 MAPK pathway in suppressing [CCN2] expression in *response* to . Regulation CTGF IL1A 24464580 2923247 The objective of the study was to examine the *regulation* of [CCN2] by inflammatory cytokines , , and TNF-a and to determine whether CCN2 modulates IL-1ß dependent catabolic gene expression in nucleus pulposus ( NP ) cells . Regulation CTGF IL1B 17989112 1850948 Inhibitory *effect* of on angiotensin II-induced [connective tissue growth factor] and type IV collagen production in cultured mesangial cells . Regulation CTGF IL4 11967989 938061 *regulates* [connective tissue growth factor] expression in human lung fibroblasts . Regulation CTGF IL4 11967989 938062 In these studies , the *regulation* of [CTGF] expression by in human lung fibroblasts was examined . Regulation CTGF IL6 21245987 2379911 However , the STAT3 SH2 domain binding peptide , a selective inhibitor of STAT3 DNA binding activity , counteracted the inhibitory *effect* of on [CCN2/CTGF] expression much more pronounced than pyrrolidine-dithiocarbamate , an inhibitor primarily of STAT3 phosphorylation . Regulation CTGF ILK 15970428 1497757 Differential *involvement* of the in RhoA dependent rearrangement of F-actin fibers and induction of [connective tissue growth factor (CTGF)] . Regulation CTGF ITCH 24101513 2858139 Concordant with phosphorylated Amot130 specifically mediating these effects , wild-type Amot130 selectively induced YAP phosphorylation and reduced transcription of [connective tissue growth factor] in an *dependent* manner versus Amot130 ( S175A ) . Regulation CTGF JUN 20222112 2281579 Transfections were used to measure the *effects* of Smads 2 , 3 , and 7 and on TGFbeta mediated [CTGF] promoter activity . Regulation CTGF KLF15 24356553 2881431 In vitro we examined the *effect* of altered expression on the production of extracellular matrix and the pro-fibrotic factor [CTGF] in rat renal fibroblasts ( NRK-49F ) , and further explored the related mechanisms . Regulation CTGF LEP 15389880 1324278 Thus , the *effects* of AGE ( 150 microg/ml ) and on mitogenesis , [CTGF] and collagen expression in NRK-49F cells were determined . Regulation CTGF LPA 17765657 1873874 Blocking experiments with the lysophosphatidic acid (LPA) receptor-specific inhibitor Ki16425 suggest a general *involvement* of receptors in bacteria triggered [CTGF] and CYR61 expression . Regulation CTGF LPA 17765657 1873875 These data suggest that receptor *dependent* expression of [CTGF] and CYR61 represents a common host response after interaction with bacteria . Regulation CTGF LPA 20965247 2365226 We decided to evaluate the *effect* of together with TGF-ß on [CTGF] expression . Regulation CTGF LPA 20965247 2365232 Finally , we demonstrated that [CTGF] induction in *response* to requires the activation of JNK , but not ERK , signaling pathways . Regulation CTGF LPAR1 17765657 1873865 Bacteria induce [CTGF] and CYR61 expression in epithelial cells in a *dependent* manner . Regulation CTGF LPAR2 17765657 1873866 Bacteria induce [CTGF] and CYR61 expression in epithelial cells in a *dependent* manner . Regulation CTGF LPAR3 17765657 1873863 Bacteria induce [CTGF] and CYR61 expression in epithelial cells in a *dependent* manner . Regulation CTGF LPAR4 17765657 1873867 Bacteria induce [CTGF] and CYR61 expression in epithelial cells in a *dependent* manner . Regulation CTGF LPAR5 17765657 1873862 Bacteria induce [CTGF] and CYR61 expression in epithelial cells in a *dependent* manner . Regulation CTGF LPAR6 17765657 1873864 Bacteria induce [CTGF] and CYR61 expression in epithelial cells in a *dependent* manner . Regulation CTGF MAP2K1 17786299 1790893 Whereas p38 mediated CTGF induction by TGFbeta in fibroblasts , signaling mediated TGFbeta induced CTGF expression in pancreatic cancer cells and was also *responsible* for basal [CTGF] expression in pancreatic cancer cell lines with defective Smad signaling . Regulation CTGF MAP2K1 19494553 2098065 TGFbeta1 increased cellular and secreted [CTGF] protein in HKC cells in a *dependent* manner . Regulation CTGF MAP2K2 17786299 1790894 Whereas p38 mediated CTGF induction by TGFbeta in fibroblasts , signaling mediated TGFbeta induced CTGF expression in pancreatic cancer cells and was also *responsible* for basal [CTGF] expression in pancreatic cancer cell lines with defective Smad signaling . Regulation CTGF MAP2K2 19494553 2098066 TGFbeta1 increased cellular and secreted [CTGF] protein in HKC cells in a *dependent* manner . Regulation CTGF MAP2K3 17786299 1790895 Whereas p38 mediated CTGF induction by TGFbeta in fibroblasts , signaling mediated TGFbeta induced CTGF expression in pancreatic cancer cells and was also *responsible* for basal [CTGF] expression in pancreatic cancer cell lines with defective Smad signaling . Regulation CTGF MAP2K3 19494553 2098067 TGFbeta1 increased cellular and secreted [CTGF] protein in HKC cells in a *dependent* manner . Regulation CTGF MAP2K4 17786299 1790896 Whereas p38 mediated CTGF induction by TGFbeta in fibroblasts , signaling mediated TGFbeta induced CTGF expression in pancreatic cancer cells and was also *responsible* for basal [CTGF] expression in pancreatic cancer cell lines with defective Smad signaling . Regulation CTGF MAP2K4 19494553 2098068 TGFbeta1 increased cellular and secreted [CTGF] protein in HKC cells in a *dependent* manner . Regulation CTGF MAP2K5 17786299 1790897 Whereas p38 mediated CTGF induction by TGFbeta in fibroblasts , signaling mediated TGFbeta induced CTGF expression in pancreatic cancer cells and was also *responsible* for basal [CTGF] expression in pancreatic cancer cell lines with defective Smad signaling . Regulation CTGF MAP2K5 19494553 2098069 TGFbeta1 increased cellular and secreted [CTGF] protein in HKC cells in a *dependent* manner . Regulation CTGF MAP2K6 17786299 1790898 Whereas p38 mediated CTGF induction by TGFbeta in fibroblasts , signaling mediated TGFbeta induced CTGF expression in pancreatic cancer cells and was also *responsible* for basal [CTGF] expression in pancreatic cancer cell lines with defective Smad signaling . Regulation CTGF MAP2K6 19494553 2098070 TGFbeta1 increased cellular and secreted [CTGF] protein in HKC cells in a *dependent* manner . Regulation CTGF MAP2K7 17786299 1790899 Whereas p38 mediated CTGF induction by TGFbeta in fibroblasts , signaling mediated TGFbeta induced CTGF expression in pancreatic cancer cells and was also *responsible* for basal [CTGF] expression in pancreatic cancer cell lines with defective Smad signaling . Regulation CTGF MAP2K7 19494553 2098071 TGFbeta1 increased cellular and secreted [CTGF] protein in HKC cells in a *dependent* manner . Regulation CTGF MAPK1 12218048 1012118 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Regulation CTGF MAPK1 16327498 1488502 inhibition had a similar *effect* on TGF-beta induced [CTGF] and fibronectin expression . Regulation CTGF MAPK1 17592071 1768174 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Regulation CTGF MAPK1 22166649 2366576 The effects of the protein kinase A (PKA) activator 8-Br-cAMP and protein kinase C ( PKC ) activator phorbol 12-myristate 13-acetate ( PMA ) on phosphorylation , and the *effects* of the PKA inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and [CTGF] expression were detected by immunoblotting assay . Regulation CTGF MAPK10 12218048 1012119 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Regulation CTGF MAPK10 17592071 1768175 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Regulation CTGF MAPK10 22166649 2366577 The effects of the protein kinase A (PKA) activator 8-Br-cAMP and protein kinase C ( PKC ) activator phorbol 12-myristate 13-acetate ( PMA ) on phosphorylation , and the *effects* of the PKA inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and [CTGF] expression were detected by immunoblotting assay . Regulation CTGF MAPK11 12218048 1012120 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Regulation CTGF MAPK11 17592071 1768176 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Regulation CTGF MAPK11 22166649 2366578 The effects of the protein kinase A (PKA) activator 8-Br-cAMP and protein kinase C ( PKC ) activator phorbol 12-myristate 13-acetate ( PMA ) on phosphorylation , and the *effects* of the PKA inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and [CTGF] expression were detected by immunoblotting assay . Regulation CTGF MAPK12 12218048 1012121 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Regulation CTGF MAPK12 17592071 1768177 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Regulation CTGF MAPK12 22166649 2366579 The effects of the protein kinase A (PKA) activator 8-Br-cAMP and protein kinase C ( PKC ) activator phorbol 12-myristate 13-acetate ( PMA ) on phosphorylation , and the *effects* of the PKA inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and [CTGF] expression were detected by immunoblotting assay . Regulation CTGF MAPK13 12218048 1012122 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Regulation CTGF MAPK13 17592071 1768178 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Regulation CTGF MAPK13 22166649 2366580 The effects of the protein kinase A (PKA) activator 8-Br-cAMP and protein kinase C ( PKC ) activator phorbol 12-myristate 13-acetate ( PMA ) on phosphorylation , and the *effects* of the PKA inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and [CTGF] expression were detected by immunoblotting assay . Regulation CTGF MAPK14 12218048 1012123 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Regulation CTGF MAPK14 17592071 1768179 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Regulation CTGF MAPK14 22166649 2366581 The effects of the protein kinase A (PKA) activator 8-Br-cAMP and protein kinase C ( PKC ) activator phorbol 12-myristate 13-acetate ( PMA ) on phosphorylation , and the *effects* of the PKA inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and [CTGF] expression were detected by immunoblotting assay . Regulation CTGF MAPK15 12218048 1012116 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Regulation CTGF MAPK15 17592071 1768173 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Regulation CTGF MAPK15 22166649 2366575 The effects of the protein kinase A (PKA) activator 8-Br-cAMP and protein kinase C ( PKC ) activator phorbol 12-myristate 13-acetate ( PMA ) on phosphorylation , and the *effects* of the PKA inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and [CTGF] expression were detected by immunoblotting assay . Regulation CTGF MAPK3 12218048 1012124 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Regulation CTGF MAPK3 15780081 1385206 Inhibition of p38 ( mapk ) or activities did not *affect* LDL induced TGF-beta1 , [CTGF] , and collagen I expression , whereas inhibition of c-Jun NH2-terminal kinase (JNK) suppressed LDL induced TGF-beta , CTGF , and collagen I expression . Regulation CTGF MAPK3 16327498 1488503 inhibition had a similar *effect* on TGF-beta induced [CTGF] and fibronectin expression . Regulation CTGF MAPK3 17592071 1768180 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Regulation CTGF MAPK3 22166649 2366582 The effects of the protein kinase A (PKA) activator 8-Br-cAMP and protein kinase C ( PKC ) activator phorbol 12-myristate 13-acetate ( PMA ) on phosphorylation , and the *effects* of the PKA inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and [CTGF] expression were detected by immunoblotting assay . Regulation CTGF MAPK4 12218048 1012125 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Regulation CTGF MAPK4 17592071 1768181 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Regulation CTGF MAPK4 22166649 2366583 The effects of the protein kinase A (PKA) activator 8-Br-cAMP and protein kinase C ( PKC ) activator phorbol 12-myristate 13-acetate ( PMA ) on phosphorylation , and the *effects* of the PKA inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and [CTGF] expression were detected by immunoblotting assay . Regulation CTGF MAPK6 12218048 1012126 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Regulation CTGF MAPK6 17592071 1768182 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Regulation CTGF MAPK6 22166649 2366584 The effects of the protein kinase A (PKA) activator 8-Br-cAMP and protein kinase C ( PKC ) activator phorbol 12-myristate 13-acetate ( PMA ) on phosphorylation , and the *effects* of the PKA inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and [CTGF] expression were detected by immunoblotting assay . Regulation CTGF MAPK7 12218048 1012127 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Regulation CTGF MAPK7 17592071 1768183 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Regulation CTGF MAPK7 22166649 2366585 The effects of the protein kinase A (PKA) activator 8-Br-cAMP and protein kinase C ( PKC ) activator phorbol 12-myristate 13-acetate ( PMA ) on phosphorylation , and the *effects* of the PKA inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and [CTGF] expression were detected by immunoblotting assay . Regulation CTGF MAPK8 12218048 1012128 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Regulation CTGF MAPK8 17592071 1768184 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Regulation CTGF MAPK8 19589256 2105285 This study was designed to investigate the *effect* of and 2 on TGF-beta(1) regulated [CTGF] gene expression and corneal scar formation in telomerase immortalized human corneal stroma fibroblast ( THSF ) cells . Regulation CTGF MAPK8 22166649 2366586 The effects of the protein kinase A (PKA) activator 8-Br-cAMP and protein kinase C ( PKC ) activator phorbol 12-myristate 13-acetate ( PMA ) on phosphorylation , and the *effects* of the PKA inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and [CTGF] expression were detected by immunoblotting assay . Regulation CTGF MAPK9 12218048 1012129 The *role* of p42/44 and protein kinase B in [connective tissue growth factor] induced extracellular matrix protein production , cell migration , and actin cytoskeletal rearrangement in human mesangial cells . Regulation CTGF MAPK9 17592071 1768185 Furthermore , activation of and JNK , and redox process were also *involved* in Ang II-mediated [CTGF] upregulation , and were downregulated by statins . Regulation CTGF MAPK9 22166649 2366587 The effects of the protein kinase A (PKA) activator 8-Br-cAMP and protein kinase C ( PKC ) activator phorbol 12-myristate 13-acetate ( PMA ) on phosphorylation , and the *effects* of the PKA inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and [CTGF] expression were detected by immunoblotting assay . Regulation CTGF MAPKAPK2 20864298 2353220 The *effect* of on intimal thickening and [connective tissue growth factor] expression was evaluated in human saphenous vein ( HSV ) rings maintained with 30 % fetal bovine serum for 14 days by light microscopy and immunoblotting . Regulation CTGF MIR18A 21501375 2475558 and microRNA-19 *regulate* [CTGF] and TSP-1 expression in age related heart failure . Regulation CTGF MMP3 18172013 1875595 Novel transcription-factor-like function of human *regulating* the [CTGF/CCN2] gene . Regulation CTGF MMP3 18172013 1875597 Furthermore , we determined that heterochromatin protein gamma coordinately *regulates* [CCN2/CTGF] by interacting with . Regulation CTGF MYLIP 19096030 2031138 and miR-30 *regulate* [connective tissue growth factor] : implications for a role of microRNAs in myocardial matrix remodeling . Regulation CTGF MYLIP 22395530 2606424 Interestingly , overexpression of could in turn negatively *regulated* TGF-ß and [connective tissue growth factor (CTGF)] expression and Smad3 signaling . Regulation CTGF MYLIP 23249750 2732279 The unexpected *effects* of on [CTGF] transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFß signaling . Regulation CTGF MYLIP 24065814 2857784 Quantitative real-time PCR ( qRT-PCR ) and Western blots were used to determine the *effect* of on [CTGF] , smooth muscle actin (SMA) , and collagen ( COL1A1 ) in RbCF . Regulation CTGF MYLIP 24185621 2890158 Importantly , and miR-18b were directly *involved* in the post-transcriptional regulation of collagen IV alpha 1 (Col4a1) and [connective tissue growth factor (CTGF)] in EWS knock-out ( KO ) mouse embryonic fibroblast cells . Regulation CTGF MYLIP 24296617 2904764 The *role* of in the regulation of Ang II-induced [CTGF] expression was evaluated in cultured cardiomyocytes with quantitative real-time reverse transcription polymerase chain reaction and Western blot analysis . Regulation CTGF NFKB1 18184857 1863075 Furthermore , aldosterone augmented the promoter activity and protein expression of intercellular adhesion molecule-1 ( ICAM-1 ) , which modulates the inflammatory response , and the profibrotic cytokine [connective tissue growth factor (CTGF)] in an SGK1- and *dependent* manner . Regulation CTGF NOV 21748432 2546610 We further found that adenoviral overexpression of CCN2/CTGF suppressed CCN3/NOV expression , while the overexpression of CCN3/NOV as well as the suppression of by targeting siRNAs both *resulted* in enhanced [CCN2/CTGF] expression . Regulation CTGF NRG1 22350758 2586840 In the presence of inhibitors of PI3K , Src , Smad , or reactive oxygen species , the *effect* of on [CTGF] expression decreased significantly . Regulation CTGF NUP43 10976101 751903 In contrast to the induction of other early response genes ( Egr-1 and cyclooxygenase-2 ) , LPA mediated induction of [CTGF] was pertussis toxin-insensitive and *independent* of MAP kinase activation . Regulation CTGF NUP43 15780081 1385205 Inhibition of p38 ( mapk ) or activities did not *affect* LDL induced TGF-beta1 , [CTGF] , and collagen I expression , whereas inhibition of c-Jun NH2-terminal kinase (JNK) suppressed LDL induced TGF-beta , CTGF , and collagen I expression . Regulation CTGF OSM 21816755 2500449 Utilizing receptor blocking molecules , we found the inhibitory *effect* of on TGF-ß1 induced [CTGF] mRNA expression occurs independently of Smad2/3 signaling and present evidence that this effect may be partially driven by OSM receptor mediated Stat1 and/or Stat3 signaling pathways , thereby providing a mechanism whereby OSM can contribute to tubulointerstitial protection . Regulation CTGF OSM 22814105 2640031 In the present study we examined the *role* of TGF-ß1- and induced signaling mechanisms in the regulation of [CTGF] mRNA expression in human proximal tubular HK-2 cells . Regulation CTGF OSM 22814105 2640036 Together these results suggest that the inhibitory *effect* of on TGF-ß1 induced [CTGF] mRNA expression is mainly driven by STAT3 , thereby providing a signaling mechanism whereby OSM may contribute to tubulointerstitial protection . Regulation CTGF PCNA 23959471 2920843 TR1 promotes cell proliferation and inhibits apoptosis through A and [CTGF] *regulation* in non-small cell lung cancer . Regulation CTGF PI3 15377500 1353923 We investigated the role of MAPKs and and the *effects* of inflammatory cytokines on TGF-beta induced [CTGF] expression in human airway smooth muscle cells ( ASMC ) . Regulation CTGF PIK3CA 19390991 2082028 Cell type-specific *regulation* of [CCN2] protein expression by signaling . Regulation CTGF PIK3R1 19390991 2082029 Cell type-specific *regulation* of [CCN2] protein expression by signaling . Regulation CTGF PRKACB 22166649 2366588 The effects of the protein kinase A (PKA) activator 8-Br-cAMP and protein kinase C ( PKC ) activator phorbol 12-myristate 13-acetate ( PMA ) on MAPK phosphorylation , and the *effects* of the inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and [CTGF] expression were detected by immunoblotting assay . Regulation CTGF PRKACG 22166649 2366589 The *effects* of the activator 8-Br-cAMP and protein kinase C ( PKC ) activator phorbol 12-myristate 13-acetate ( PMA ) on MAPK phosphorylation , and the effects of the PKA inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and [CTGF] expression were detected by immunoblotting assay . Regulation CTGF PRKAR1A 22166649 2366590 The effects of the protein kinase A (PKA) activator 8-Br-cAMP and protein kinase C ( PKC ) activator phorbol 12-myristate 13-acetate ( PMA ) on MAPK phosphorylation , and the *effects* of the inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and [CTGF] expression were detected by immunoblotting assay . Regulation CTGF PRKAR1B 22166649 2366591 The *effects* of the activator 8-Br-cAMP and protein kinase C ( PKC ) activator phorbol 12-myristate 13-acetate ( PMA ) on MAPK phosphorylation , and the effects of the PKA inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and [CTGF] expression were detected by immunoblotting assay . Regulation CTGF PRKAR2A 22166649 2366592 The effects of the protein kinase A (PKA) activator 8-Br-cAMP and protein kinase C ( PKC ) activator phorbol 12-myristate 13-acetate ( PMA ) on MAPK phosphorylation , and the *effects* of the inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and [CTGF] expression were detected by immunoblotting assay . Regulation CTGF PRKAR2B 22166649 2366593 The *effects* of the activator 8-Br-cAMP and protein kinase C ( PKC ) activator phorbol 12-myristate 13-acetate ( PMA ) on MAPK phosphorylation , and the effects of the PKA inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and [CTGF] expression were detected by immunoblotting assay . Regulation CTGF PROK1 21098624 2372043 The first aim of the study was to determine the *effect* of on [CTGF] expression in PROKR1-Ishikawa cells and first-trimester decidua samples . Regulation CTGF PROK1 21098624 2372045 Inhibitors of specific cell signalling molecules demonstrated that *regulates* [CTGF] expression via the Gq , phospholipase C (PLC) , cSrc , epidermal growth factor receptor (EGFR) , mitogen activated protein kinase/extracellular signal regulated kinase ( MAPK/ERK ) kinase pathway activation . Regulation CTGF PROK1 21098624 2372047 [CTGF] expression in early pregnancy decidua is *regulated* by , via activation of the Gq , PLC , cSrc , EGFR , MAPK/ERK kinase pathway . Regulation CTGF PTH 20810452 2388953 Moreover , both PD98059 and PDTC inhibited the *effect* of on the expression of [CTGF] , which strongly suggests that these pathways play important roles in the PTH induced CTGF upregulation in renal tubular cells . Regulation CTGF PTX3 15987746 1446782 The protein kinase A antagonist H89 abolished the inhibitory *effect* of on Smad3/4 dependent [CTGF] transcription , whereas dibutyryl cAMP and forskolin recapitulated the inhibitory effect . Regulation CTGF PTX4 15987746 1446781 The protein kinase A antagonist H89 abolished the inhibitory *effect* of on Smad3/4 dependent [CTGF] transcription , whereas dibutyryl cAMP and forskolin recapitulated the inhibitory effect . Regulation CTGF RAC1 18760941 2034449 signaling *regulates* [CTGF/CCN2] gene expression via TGFbeta/Smad signaling in chondrocytes . Regulation CTGF RBBP4 20141616 2178984 Therefore , we hypothesized that , which modulate the accessibility of transcriptionally active promoter regions , might *play* a role in the regulation of [CTGF] gene expression . Regulation CTGF RBBP4 20141616 2178988 Taken together , our data indicate that the *effect* of inhibitors on [CTGF] expression is largely cell dependent in non-tumour cells . Regulation CTGF RBBP7 20141616 2178985 Therefore , we hypothesized that , which modulate the accessibility of transcriptionally active promoter regions , might *play* a role in the regulation of [CTGF] gene expression . Regulation CTGF RBBP7 20141616 2178989 Taken together , our data indicate that the *effect* of inhibitors on [CTGF] expression is largely cell dependent in non-tumour cells . Regulation CTGF RELA 18184857 1863076 Furthermore , aldosterone augmented the promoter activity and protein expression of intercellular adhesion molecule-1 ( ICAM-1 ) , which modulates the inflammatory response , and the profibrotic cytokine [connective tissue growth factor (CTGF)] in an SGK1- and *dependent* manner . Regulation CTGF RENBP 15389880 1324279 Thus , the *effects* of ( 150 microg/ml ) and leptin on mitogenesis , [CTGF] and collagen expression in NRK-49F cells were determined . Regulation CTGF RENBP 18805993 2021185 and GDPs in PDS differentially *regulate* the synthesis of [CCN2] by peritoneal resident cells . Regulation CTGF RHOA 15560785 1341062 In particular , dependent *regulation* of the [CTGF/CCN2] gene was concomitant to increased polymerization of actin microfilaments resulting in decreased G- to F-actin ratio and appeared to be achieved at the transcriptional level . Regulation CTGF RHOA 15970428 1497758 Differential involvement of the integrin linked kinase (ILK) in *dependent* rearrangement of F-actin fibers and induction of [connective tissue growth factor (CTGF)] . Regulation CTGF RHOA 15970428 1497764 Inhibition of the RhoA associated kinase or overexpression of dominant negative RhoA reduced the stimulated CTGF expression indicative of a *role* for signaling in [CTGF] expression . Regulation CTGF RUNX2 21986102 2539633 complex negatively *regulates* TGF-ß induced [connective tissue growth factor] gene expression in vascular smooth muscle cells . Regulation CTGF RUNX2 21986102 2539639 These results for the first time demonstrate that complex negatively *regulates* endogenous and TGF-ß induced [CTGF] gene expression in VSMCs . Regulation CTGF SERPINA3 20299474 2281617 The purpose of this study was to investigate the *role* of in the regulation of [CTGF] and fibrogenesis and its mechanism of action . Regulation CTGF SFTPC 17592175 1779386 Blocking TGFbeta signaling by a TGFbeta receptor kinase inhibitor causes an inhibition of SPC stimulated Smad activation and reverses both the negative effect of on sPLA ( 2 ) expression and the positive *effect* on [CTGF] expression . Regulation CTGF SGK1 16604333 1550800 *dependent* cardiac [CTGF] formation and fibrosis following DOCA treatment . Regulation CTGF SGK1 16604333 1550801 Our results suggest that *plays* a decisive role in mineralocorticoid induced [CTGF] expression and cardiac fibrosis . Regulation CTGF SGK1 18319604 1897565 *dependent* upregulation of [connective tissue growth factor] by angiotensin II . Regulation CTGF SGK1 18846327 1976887 By using RT-PCR and Western blot , the *effect* of on the [CTGF] expression in HMCs under high glucose was examined . Regulation CTGF SMAD1 11152469 795339 [CTGF] and SMADs , maintenance of scleroderma phenotype is *independent* of signaling . Regulation CTGF SMAD1 15855807 1425646 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Regulation CTGF SMAD1 18314002 1897498 To investigate the *involvement* of the TGF-beta1 response element (TRE) and the in [CTGF] induction , we cloned the rat CTGF proximal promoter ( -787 to +1 ) containing the TRE and SBE motifs into a pGL3-Luciferase reporter construct . Regulation CTGF SMAD1 20522428 2271259 CONCLUSIONS These findings provide the first evidence that variants within the promoter region of the CTGF/CCN2 gene predisposes diabetic subjects to develop albuminuria and demonstrate that [ corrected ] *controls* the expression of [CTGF/CCN2] promoter through this region . Regulation CTGF SMAD2 11152469 795340 [CTGF] and SMADs , maintenance of scleroderma phenotype is *independent* of signaling . Regulation CTGF SMAD2 15855807 1425647 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Regulation CTGF SMAD2 17317656 1719555 We demonstrate that the TGF-betaRI dependent up-regulation of collagen and [CCN2] ( CTGF ) does not *involve* activation but is mediated by ALK1/Smad1 and ERK1/2 pathways . Regulation CTGF SMAD2 18314002 1897499 To investigate the *involvement* of the TGF-beta1 response element (TRE) and the in [CTGF] induction , we cloned the rat CTGF proximal promoter ( -787 to +1 ) containing the TRE and SBE motifs into a pGL3-Luciferase reporter construct . Regulation CTGF SMAD2 19667256 2138706 We found that Ang II-induced tubular [CTGF] and collagen I mRNA and protein expressions were *regulated* positively by phosphorylated but negatively by Smad7 because overexpression of Smad7 abolished Ang II-induced Smad2/3 phosphorylation and upregulation of CTGF and collagen I in vitro and in a rat model of remnant kidney disease . Regulation CTGF SMAD2 21245987 2379909 The inhibition of TGFß1 driven [CCN2/CTGF] expression by IL-6 did not *involve* a modulation of ( and Smad1/3 ) signalling . Regulation CTGF SMAD2 23287510 2745973 In summary , we provide strong evidence that AngII exposure first resulted in *dependent* production of [CTGF] by resident cells ( 6 hours ) , well before the accumulation of fibrocytes or TGF-ß mRNA up-regulation . Regulation CTGF SMAD3 11152469 795341 [CTGF] and SMADs , maintenance of scleroderma phenotype is *independent* of signaling . Regulation CTGF SMAD3 15855807 1425648 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Regulation CTGF SMAD3 17317656 1719556 We demonstrate that the TGF-betaRI dependent up-regulation of collagen and [CCN2] ( CTGF ) does not *involve* activation but is mediated by ALK1/Smad1 and ERK1/2 pathways . Regulation CTGF SMAD3 18314002 1897500 To investigate the *involvement* of the TGF-beta1 response element (TRE) and the in [CTGF] induction , we cloned the rat CTGF proximal promoter ( -787 to +1 ) containing the TRE and SBE motifs into a pGL3-Luciferase reporter construct . Regulation CTGF SMAD3 19570811 2142559 This arterial cell-cell communication is likely to be mediated by *dependent* production of [CTGF] . Regulation CTGF SMAD3 19667256 2138707 We found that Ang II-induced tubular [CTGF] and collagen I mRNA and protein expressions were *regulated* positively by phosphorylated but negatively by Smad7 because overexpression of Smad7 abolished Ang II-induced Smad2/3 phosphorylation and upregulation of CTGF and collagen I in vitro and in a rat model of remnant kidney disease . Regulation CTGF SMAD3 21986102 2539634 complex negatively *regulates* TGF-ß induced [connective tissue growth factor] gene expression in vascular smooth muscle cells . Regulation CTGF SMAD3 21986102 2539640 These results for the first time demonstrate that complex negatively *regulates* endogenous and TGF-ß induced [CTGF] gene expression in VSMCs . Regulation CTGF SMAD4 11152469 795342 [CTGF] and SMADs , maintenance of scleroderma phenotype is *independent* of signaling . Regulation CTGF SMAD4 15855807 1425649 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Regulation CTGF SMAD4 18314002 1897501 To investigate the *involvement* of the TGF-beta1 response element (TRE) and the in [CTGF] induction , we cloned the rat CTGF proximal promoter ( -787 to +1 ) containing the TRE and SBE motifs into a pGL3-Luciferase reporter construct . Regulation CTGF SMAD5 11152469 795343 [CTGF] and SMADs , maintenance of scleroderma phenotype is *independent* of signaling . Regulation CTGF SMAD5 15855807 1425650 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Regulation CTGF SMAD5 18314002 1897502 To investigate the *involvement* of the TGF-beta1 response element (TRE) and the in [CTGF] induction , we cloned the rat CTGF proximal promoter ( -787 to +1 ) containing the TRE and SBE motifs into a pGL3-Luciferase reporter construct . Regulation CTGF SMAD6 11152469 795344 [CTGF] and SMADs , maintenance of scleroderma phenotype is *independent* of signaling . Regulation CTGF SMAD6 15855807 1425651 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Regulation CTGF SMAD6 18314002 1897503 To investigate the *involvement* of the TGF-beta1 response element (TRE) and the in [CTGF] induction , we cloned the rat CTGF proximal promoter ( -787 to +1 ) containing the TRE and SBE motifs into a pGL3-Luciferase reporter construct . Regulation CTGF SMAD7 11152469 795345 [CTGF] and SMADs , maintenance of scleroderma phenotype is *independent* of signaling . Regulation CTGF SMAD7 15855807 1425652 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Regulation CTGF SMAD7 18314002 1897504 To investigate the *involvement* of the TGF-beta1 response element (TRE) and the in [CTGF] induction , we cloned the rat CTGF proximal promoter ( -787 to +1 ) containing the TRE and SBE motifs into a pGL3-Luciferase reporter construct . Regulation CTGF SMAD7 19667256 2138708 We found that Ang II-induced tubular [CTGF] and collagen I mRNA and protein expressions were *regulated* positively by phosphorylated Smad2/3 but negatively by because overexpression of Smad7 abolished Ang II-induced Smad2/3 phosphorylation and upregulation of CTGF and collagen I in vitro and in a rat model of remnant kidney disease . Regulation CTGF SMAD9 11152469 795346 [CTGF] and SMADs , maintenance of scleroderma phenotype is *independent* of signaling . Regulation CTGF SMAD9 15855807 1425653 While chemical inhibitors were used to assess the role of Ras/MEK/ERK1,2 signalling , an HKC cell line over expressing Smad7 was used to assess the *role* of signalling in induction of [CCN2] by TGF-beta1 . Regulation CTGF SMAD9 18314002 1897505 To investigate the *involvement* of the TGF-beta1 response element (TRE) and the in [CTGF] induction , we cloned the rat CTGF proximal promoter ( -787 to +1 ) containing the TRE and SBE motifs into a pGL3-Luciferase reporter construct . Regulation CTGF SRC 23108098 2721398 In this study , we further investigated the *roles* of , JAK2 , and STAT3 in thrombin induced [CCN2] expression . Regulation CTGF STAT6 21804025 2467680 Furthermore , IL-13 induces Stat6 phosphorylation in HSCs , but was not *involved* in [CTGF] induction . Regulation CTGF TAT 22461303 2624499 However , tempol , apocynin , and had no *effect* on [CTGF] in the absence of ANG II . Regulation CTGF TCF12 18172013 1875584 Novel function of human matrix metalloproteinase 3 *regulating* the [CTGF/CCN2] gene . Regulation CTGF TCF15 18172013 1875585 Novel function of human matrix metalloproteinase 3 *regulating* the [CTGF/CCN2] gene . Regulation CTGF TCF19 18172013 1875586 Novel function of human matrix metalloproteinase 3 *regulating* the [CTGF/CCN2] gene . Regulation CTGF TCF20 18172013 1875587 Novel function of human matrix metalloproteinase 3 *regulating* the [CTGF/CCN2] gene . Regulation CTGF TCF21 18172013 1875588 Novel function of human matrix metalloproteinase 3 *regulating* the [CTGF/CCN2] gene . Regulation CTGF TCF23 18172013 1875592 Novel function of human matrix metalloproteinase 3 *regulating* the [CTGF/CCN2] gene . Regulation CTGF TCF24 18172013 1875594 Novel function of human matrix metalloproteinase 3 *regulating* the [CTGF/CCN2] gene . Regulation CTGF TCF25 18172013 1875593 Novel function of human matrix metalloproteinase 3 *regulating* the [CTGF/CCN2] gene . Regulation CTGF TCF3 18172013 1875589 Novel function of human matrix metalloproteinase 3 *regulating* the [CTGF/CCN2] gene . Regulation CTGF TCF4 18172013 1875590 Novel function of human matrix metalloproteinase 3 *regulating* the [CTGF/CCN2] gene . Regulation CTGF TCF7 18172013 1875591 Novel function of human matrix metalloproteinase 3 *regulating* the [CTGF/CCN2] gene . Regulation CTGF TGFB1 10616214 575828 In addition , *regulation* of [connective tissue growth factor (CTGF)] was assessed in human gingival cells and tissues . Regulation CTGF TGFB1 11518710 868663 [Connective tissue growth factor (CTGF)] expression is *regulated* by ( TGF-beta ) and strong up-regulation occurs during wound healing ; Regulation CTGF TGFB1 12502478 1033740 The differential [connective tissue growth factor] *response* to in asthmatic airway smooth muscle identifies a potential role for connective tissue growth factor in the remodeling that is characteristic of severe persistent asthma . Regulation CTGF TGFB1 14635403 1171127 We therefore immunochemically investigated the pathogenesis of paraneoplastic syndrome and found that [connective tissue growth factor (CTGF)] might be involved and ( TGF-beta ) might not be *involved* in this case . Regulation CTGF TGFB1 15066218 1231662 *Effect* of on activity of [connective tissue growth factor] gene promoter in mouse NIH/3T3 fibroblasts . Regulation CTGF TGFB1 15144593 1247593 To assess the expression of connective tissue growth factor (CTGF) , and the signaling pathway for the *regulation* of [CTGF] by ( TGF beta(1) ) in podocytes . Regulation CTGF TGFB1 15144593 1247595 In this study , we observed the effects of three potent profibrotic growth factors-TGF beta(1) , Platelet derived growth factor ( PDGF ) , and Angiotensin II ( AngII ) on the expression of CTGF protein by Western blot analysis in cultured mouse podocytes , which is one of the most important cell construction of glomerular filter barrier , and we also investigated the underlying ERK and Smads signaling pathway through which *regulates* [CTGF] expression . Regulation CTGF TGFB1 15703462 1382795 Differential *effects* of on the synthesis of [connective tissue growth factor] and vascular endothelial growth factor by peritoneal mesothelial cell . Regulation CTGF TGFB1 15780081 1385180 To explore if [CTGF] and collagen I are downstream *targets* for regulation by ( TGF-beta ) , mesangial cells were treated with various concentration of TGF-beta for 24 hours . Regulation CTGF TGFB1 15855807 1425628 Induction of [CCN2] in *response* to was studied at the gene promoter level by reporter gene assay , mRNA by semi-quantitative RT-PCR and protein by immunoblotting . Regulation CTGF TGFB1 15855807 1425666 *dependent* [CCN2] promoter activity was reduced by inhibiting Ras and MEK activation . Regulation CTGF TGFB1 16100286 1498840 Our aim in this study was to examine the *effect* of on the release of [connective tissue growth factor] and vascular endothelial growth factor from human airway smooth muscle cells derived from asthmatic and nonasthmatic patients . Regulation CTGF TGFB1 16272194 1532192 To explore the mechanisms by which LDL regulates CTGF and collagen IV expression in HAECs , we determined first if [CTGF] and collagen IV are downstream *targets* for regulation by ( TGF-beta ) . Regulation CTGF TGFB1 16838391 1613057 Expression and *regulation* of [connective tissue growth factor] by and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn 's disease . Regulation CTGF TGFB1 17133596 1661435 SPARC , an upstream regulator of [connective tissue growth factor] in *response* to stimulation . Regulation CTGF TGFB1 17412405 1748704 The *regulation* of [CTGF] by histamine and in lung fibroblasts was analyzed by RT-PCR , real-time PCR , Western blot analysis , and promoter analysis and characterized by specific histamine-receptor antagonists . Regulation CTGF TGFB1 17629588 1798550 We investigated the *effect* of on [CTGF/CCN2] expression in cultured rat hepatic stellate cells and hepatocytes by means of Western and Northern blotting , immunocytochemistry , reporter gene analysis , and metabolic labelling . Regulation CTGF TGFB1 17996907 1866776 Co-localization of TGF-beta1 and CTGF in activated fibroblasts suggests that [CTGF] expression is *regulated* by through a paracrine/autocrine mechanism . Regulation CTGF TGFB1 18287089 1891395 TGFbeta1 does not stimulate RhoA activation in gingival fibroblasts , and the overexpression of dominant negative RhoA does not reduce [CCN2/CTGF] expression in *response* to . Regulation CTGF TGFB1 19210343 2044304 *Effect* of on expression of the [connective tissue growth factor] ( CCN2/CTGF ) gene in normal human gingival fibroblasts and periodontal ligament cells . Regulation CTGF TGFB1 19210343 2044305 This study investigated the *effects* of on the expression of the [CCN2/CTGF] gene in human gingival fibroblasts and periodontal ligament cells in vitro . Regulation CTGF TGFB1 19210343 2044306 The *effects* of on [CCN2/CTGF] mRNA expression were measured by reverse transcription-polymerase chain reaction . Regulation CTGF TGFB1 19291178 2106042 Based on reports of a hepatoprotective effect of coffee consumption , we were the first to provide evidence that caffeine suppresses *dependent* and -independent [CTGF] expression in hepatocytes in vitro and in vivo , thus suggesting this xanthine-alkaloid as a potential therapeutic agent . Regulation CTGF TGFB1 19589256 2105284 This study was designed to investigate the effect of c-Jun N-terminal kinase (JNK) 1 and 2 on *regulated* [CTGF] gene expression and corneal scar formation in telomerase immortalized human corneal stroma fibroblast ( THSF ) cells . Regulation CTGF TGFB1 20067105 2177750 The *effect* of , Staurosporine , PD98059 and matrine on the expression of [CTGF] , CTGF mRNA , p-Smad2 , and p-ERK1/2 were evaluated by Western blot in cultured HLF-02 cells . Regulation CTGF TGFB1 20222112 2281576 To investigate ( TGFbeta ) *regulation* of [connective tissue growth factor (CTGF)] expression in cells of the nucleus pulposus of rats , mice , and humans . Regulation CTGF TGFB2 11518710 868664 [Connective tissue growth factor (CTGF)] expression is *regulated* by ( TGF-beta ) and strong up-regulation occurs during wound healing ; Regulation CTGF TGFB2 12502478 1033741 The differential [connective tissue growth factor] *response* to in asthmatic airway smooth muscle identifies a potential role for connective tissue growth factor in the remodeling that is characteristic of severe persistent asthma . Regulation CTGF TGFB2 14635403 1171128 We therefore immunochemically investigated the pathogenesis of paraneoplastic syndrome and found that [connective tissue growth factor (CTGF)] might be involved and ( TGF-beta ) might not be *involved* in this case . Regulation CTGF TGFB2 15066218 1231663 *Effect* of on activity of [connective tissue growth factor] gene promoter in mouse NIH/3T3 fibroblasts . Regulation CTGF TGFB2 15703462 1382796 Differential *effects* of on the synthesis of [connective tissue growth factor] and vascular endothelial growth factor by peritoneal mesothelial cell . Regulation CTGF TGFB2 15780081 1385181 To explore if [CTGF] and collagen I are downstream *targets* for regulation by ( TGF-beta ) , mesangial cells were treated with various concentration of TGF-beta for 24 hours . Regulation CTGF TGFB2 16100286 1498841 Our aim in this study was to examine the *effect* of on the release of [connective tissue growth factor] and vascular endothelial growth factor from human airway smooth muscle cells derived from asthmatic and nonasthmatic patients . Regulation CTGF TGFB2 16272194 1532193 To explore the mechanisms by which LDL regulates CTGF and collagen IV expression in HAECs , we determined first if [CTGF] and collagen IV are downstream *targets* for regulation by ( TGF-beta ) . Regulation CTGF TGFB2 16838391 1613058 Expression and *regulation* of [connective tissue growth factor] by and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn 's disease . Regulation CTGF TGFB2 17133596 1661436 SPARC , an upstream regulator of [connective tissue growth factor] in *response* to stimulation . Regulation CTGF TGFB2 19291178 2106043 Based on reports of a hepatoprotective effect of coffee consumption , we were the first to provide evidence that caffeine suppresses *dependent* and -independent [CTGF] expression in hepatocytes in vitro and in vivo , thus suggesting this xanthine-alkaloid as a potential therapeutic agent . Regulation CTGF TGFB2 20222112 2281577 To investigate ( TGFbeta ) *regulation* of [connective tissue growth factor (CTGF)] expression in cells of the nucleus pulposus of rats , mice , and humans . Regulation CTGF TGFB3 11518710 868665 [Connective tissue growth factor (CTGF)] expression is *regulated* by ( TGF-beta ) and strong up-regulation occurs during wound healing ; Regulation CTGF TGFB3 12502478 1033742 The differential [connective tissue growth factor] *response* to in asthmatic airway smooth muscle identifies a potential role for connective tissue growth factor in the remodeling that is characteristic of severe persistent asthma . Regulation CTGF TGFB3 14635403 1171129 We therefore immunochemically investigated the pathogenesis of paraneoplastic syndrome and found that [connective tissue growth factor (CTGF)] might be involved and ( TGF-beta ) might not be *involved* in this case . Regulation CTGF TGFB3 15066218 1231664 *Effect* of on activity of [connective tissue growth factor] gene promoter in mouse NIH/3T3 fibroblasts . Regulation CTGF TGFB3 15703462 1382797 Differential *effects* of on the synthesis of [connective tissue growth factor] and vascular endothelial growth factor by peritoneal mesothelial cell . Regulation CTGF TGFB3 15780081 1385182 To explore if [CTGF] and collagen I are downstream *targets* for regulation by ( TGF-beta ) , mesangial cells were treated with various concentration of TGF-beta for 24 hours . Regulation CTGF TGFB3 16100286 1498842 Our aim in this study was to examine the *effect* of on the release of [connective tissue growth factor] and vascular endothelial growth factor from human airway smooth muscle cells derived from asthmatic and nonasthmatic patients . Regulation CTGF TGFB3 16272194 1532194 To explore the mechanisms by which LDL regulates CTGF and collagen IV expression in HAECs , we determined first if [CTGF] and collagen IV are downstream *targets* for regulation by ( TGF-beta ) . Regulation CTGF TGFB3 16838391 1613059 Expression and *regulation* of [connective tissue growth factor] by and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn 's disease . Regulation CTGF TGFB3 17133596 1661437 SPARC , an upstream regulator of [connective tissue growth factor] in *response* to stimulation . Regulation CTGF TGFB3 19291178 2106044 Based on reports of a hepatoprotective effect of coffee consumption , we were the first to provide evidence that caffeine suppresses *dependent* and -independent [CTGF] expression in hepatocytes in vitro and in vivo , thus suggesting this xanthine-alkaloid as a potential therapeutic agent . Regulation CTGF TGFB3 20222112 2281578 To investigate ( TGFbeta ) *regulation* of [connective tissue growth factor (CTGF)] expression in cells of the nucleus pulposus of rats , mice , and humans . Regulation CTGF TGFBR1 22099397 2585509 Moreover , inhibition using the SB431542 inhibitor significantly *affected* [CTGF] expression only at later time points whereas ERK1/2 inhibition completely abrogated CTGF expression . Regulation CTGF THBS1 16869004 1607361 These results document a *role* for in regulating [CTGF] gene and protein expression in synovial tissue , suggesting a link with the disease course in this model of RA . Regulation CTGF TNF 11509128 848246 To investigate the *effect* of on the expression of [connective tissue growth factor (CTGF)] in rat hepatic stellate cells (HSC) in vitro . Regulation CTGF TNF 12787426 1097010 In contrast , platelet derived growth factor ( PDGF ) , epidermal growth factor (EGF) , and had no measurable *effects* on [CTGF] mRNA expression . Regulation CTGF TNF 17376761 1766030 , but not IFN-gamma , *regulates* [CCN2] ( CTGF ) , collagen type I , and proliferation in mesangial cells : possible roles in the progression of renal fibrosis . Regulation CTGF TNF 19385047 2069260 In this study , we found the inhibitory *effect* of on TGF-beta induced [CTGF] expression in WT but not p65-/-MEF cells . Regulation CTGF TNF 22164494 2515529 Paeoniflorin may exert its effects by inhibiting the serum level of and down *regulating* the expression of [CTGF] and PDGF proteins . Regulation CTGF TNF 23029004 2680747 Besides the inhibitory *effect* of IFN-? and alone on [CTGF] expression and LEC proliferation , these cytokines had an additive inhibitory effect on proliferation as well as on CTGF expression when administered together . Regulation CTGF TNF 23029004 2680748 In addition , an additive *effect* of IFN-? and on inhibition of [CTGF] expression and cell proliferation could be found . Regulation CTGF TNF 24464580 2923246 The objective of the study was to examine the *regulation* of [CCN2] by inflammatory cytokines , IL-1ß , and and to determine whether CCN2 modulates IL-1ß dependent catabolic gene expression in nucleus pulposus ( NP ) cells . Regulation CTGF TRNAE1 18314002 1897497 To investigate the *involvement* of the and the SMAD binding element (SBE) in [CTGF] induction , we cloned the rat CTGF proximal promoter ( -787 to +1 ) containing the TRE and SBE motifs into a pGL3-Luciferase reporter construct . Regulation CTGF VEGFA 11018037 752826 Since connective tissue growth factor (CTGF) is a potent mitogen for fibrosis , extracellular matrix production , and angiogenesis , we have studied the effects and mechanism by which ( VEGF ) *regulates* [CTGF] gene expression in retinal capillary cells . Regulation CTGF VEGFA 18835464 2012871 We have demonstrated that *regulates* the expression of CCN2/connective tissue growth factor ( [CCN2/CTGF] ) an essential mediator of cartilage development and angiogenesis , suggesting that CCN2 functions in down-stream of VEGF , and that VEGF function is mediated in part by CCN2 . Regulation CTGF WNT1 20299474 2281635 Dickkopf-1 , a specific Wnt antagonist , also attenuated the high-glucose induced CTGF overexpression , indicating a *role* of signaling in [CTGF] overexpression in diabetes . Regulation CTGF WNT11 20299474 2281636 Dickkopf-1 , a specific Wnt antagonist , also attenuated the high-glucose induced CTGF overexpression , indicating a *role* of signaling in [CTGF] overexpression in diabetes . Regulation CTGF WNT16 20299474 2281641 Dickkopf-1 , a specific Wnt antagonist , also attenuated the high-glucose induced CTGF overexpression , indicating a *role* of signaling in [CTGF] overexpression in diabetes . Regulation CTGF WNT2 20299474 2281637 Dickkopf-1 , a specific Wnt antagonist , also attenuated the high-glucose induced CTGF overexpression , indicating a *role* of signaling in [CTGF] overexpression in diabetes . Regulation CTGF WNT3 20299474 2281638 Dickkopf-1 , a specific Wnt antagonist , also attenuated the high-glucose induced CTGF overexpression , indicating a *role* of signaling in [CTGF] overexpression in diabetes . Regulation CTGF WNT4 20299474 2281639 Dickkopf-1 , a specific Wnt antagonist , also attenuated the high-glucose induced CTGF overexpression , indicating a *role* of signaling in [CTGF] overexpression in diabetes . Regulation CTGF WNT6 20299474 2281640 Dickkopf-1 , a specific Wnt antagonist , also attenuated the high-glucose induced CTGF overexpression , indicating a *role* of signaling in [CTGF] overexpression in diabetes . Regulation CTGF WT1 10973960 751885 *regulation* of [CTGF] expression is not mediated by previously identified WT1 recognition elements and may therefore involve a novel mechanism . Regulation CTNNAL1 IKBKB 17952117 1889012 [Alpha-catulin] , a Rho signalling component , can *regulate* NF-kappaB through binding to , and confers resistance to apoptosis . Regulation CTNNB1 ARSA 15567157 1355454 We compared the *effects* of aspirin ( ASA ) and the ortho , meta , and para positional isomers of NO-donating aspirin ( ) on cell growth and [beta-catenin] expression in human Jurkat T leukemic cells . Regulation CTNNB1 AXIN2 10049590 592661 or Axil , an Axin homolog , *plays* an important role in the regulation of [beta-catenin] stability in the Wnt signaling pathway . Regulation CTNNB1 AXIN2 10330181 614244 Although expression of Axin in SW480 cells caused the degradation of beta-catenin and reduced the cell growth rate , expression of an mutant that lacks the DIX domain did not *affect* the level of [beta-catenin] or the growth rate . Regulation CTNNB1 AXIN2 10330403 614373 Some forms of lacking the beta-catenin binding site can still interact indirectly with beta-catenin and *regulate* [beta-catenin] levels and axis formation . Regulation CTNNB1 AXIN2 10488109 645241 These results suggest that Axin regulates the stability of plakoglobin by enhancing its phosphorylation by GSK-3beta and that may *act* on [beta-catenin] and plakoglobin in similar manners . Regulation CTNNB1 AXIN2 10811618 693078 In the absence of Wnt signal , and APC *regulate* cytoplasmic levels of the proto-oncogene [beta-catenin] through the formation of a large complex containing these three proteins , glycogen synthase kinase 3beta ( GSK3beta ) and several other proteins . Regulation CTNNB1 AXIN2 11738041 885908 This inhibits the *dependent* phosphorylation of [beta-catenin] by GSK-3 . Regulation CTNNB1 AXIN2 14981260 1214321 Nuclear-cytoplasmic shuttling of *regulates* subcellular localization of [beta-catenin] . Regulation CTNNB1 AXIN2 14981260 1214330 is a negative regulator of the Wnt signaling pathway , and it is *responsible* for the formation of the [beta-catenin] degradation complex . Regulation CTNNB1 AXIN2 19075000 2030723 N-cadherin interacts with and LRP5 to negatively *regulate* [Wnt/beta-catenin] signaling , osteoblast function , and bone formation . Regulation CTNNB1 AXIN2 19075000 2030832 These data indicate that a previously unrecognized interaction negatively *regulates* [Wnt/beta-catenin] signaling and is critical in the regulation of osteoblast function , bone formation , and bone mass . Regulation CTNNB1 AXIN2 20300119 2230407 We show that , a negative *regulator* of [beta-catenin] , localizes at the centrosomes by binding to the centriole associated component C-Nap1 . Regulation CTNNB1 CCND1 17122440 1661174 To determine whether [beta-catenin/TCF] signaling *regulates* VSMC proliferation via modulation of the beta-catenin/TCF responsive cell cycle genes , and p21 , we inhibited beta-catenin/TCF signaling by adenoviral mediated over-expression of N-Cadherin , ICAT ( an endogenous inhibitor of beta-catenin/TCF signaling ) , or a dominant negative ( dn ) mutant of TCF-4 . Regulation CTNNB1 EFNB1 12408869 1010317 We show here that [beta-catenin] and TCF inversely *control* the expression of the EphB2/EphB3 receptors and their ligand in colorectal cancer and along the crypt-villus axis . Regulation CTNNB1 PECAM1 10801826 707973 Recently we demonstrated that association functions to *regulate* [beta-catenin] localization and , moreover , to modulate beta-catenin tyrosine phosphorylation levels . Regulation CTNNB1 PECAM1 16816383 1581008 *affects* GSK-3beta mediated [beta-catenin] phosphorylation and degradation . Regulation CTNNB1 TF 17912456 1803860 differentially *regulated* E-cadherin and [beta-catenin] in these cells . Regulation CTNNB1 TNF 17766589 1822812 However , the expression of the EYFP-Y198F beta-actin and EYFP-Y218F beta-actin prevented the *effect* of on [beta-catenin] and barrier function . Regulation CTNNB1 TP63 17297296 1698907 However , is also *involved* in RNA processing and activation of [beta-catenin] signaling . Regulation CTNNBL1 EPHB2 12672049 1076383 These results demonstrate that [HP-NAP] activates neutrophils through a PTX-sensitive pathway and that and p38-MAPK are *involved* in many neutrophil functions stimulated by HP-NAP . Regulation CTR9 ALOX5 3152458 104200 This suggests that <5-lipoxygenase> *dependent* mediators and [PAF] are involved in allergic contact dermatitis and that these mediators play only a minor role in irritant dermatitis . Regulation CTR9 ALOX5 7488299 323020 This study has examined the *effects* of a new <5-lipoxygenase> inhibitor , 6-hydroxy-2- ( 4-sulfamoylbenzylamino ) -4,5,7-trimethylbenzothiazo le hydrochloride ( CAS 120164-49-0 , E6080 ) on the release of LTC4 , LTB4 and [PAF] by human eosinophils , Eosinophils stimulated by 1 mumol/l calcium ionophore A23187 for 15 min released 37.5 +/- 2.2 ng , 2.3 +/- 0.3 ng and 4.0 +/- 0.3 pmol per 10 ( 6 ) cells of immunoreactive LTC4 , LTB4 and PAF , respectively ( mean +/- SEM , n = 4 ) . Regulation CTR9 ARSA 8107285 246009 Next , synthesized PAF from washed platelets or washed leukocytes stimulated with collagen or ONO-11113 ( STA2 ; stable analogue of thromboxane A2 ) , and the inhibiting *effects* of on the [PAF] synthesis from collagen stimulated leukocytes were examined , using a radioimmunoassay kit for PAF . Regulation CTR9 EDN2 2051719 161773 The purpose of the present series of experiments has been to analyze the functional relations between the *effect* of on renal function and glomerular and mesangial cell contraction and the production and actions of [PAF] in kidney . Regulation CTR9 F2R 10395981 627773 The *effect* of a agonist peptide ( TRAP-6 ) on the release of nitric oxide ( NO ) and [platelet activating factor (PAF)] from resting and calcium-ionophore ( A23187 ) -activated rat peritoneal mast cells ( RPMC ) was studied using a platelet aggregation bioassay . Regulation CTR9 TNF 1499148 193555 4. Furthermore , we investigated the priming *effect* of recombinant human , which is known to be one of the most important mediators in the development of ARDS , on [PAF] production induced by the calcium ionophore in neutrophils . Regulation CTR9 TNF 1846897 153386 We have further examined the *effects* of on arachidonic acid ( AA ) release , LTB4 production , and [platelet activating factor (PAF)] formation in PMN by prelabeling cells with either [ 3H ] AA or [ 3H ] lyso-PAF , priming with human rTNF-alpha , and then stimulating with the chemotactic peptide , FMLP . Regulation CTR9 TNF 3119758 80241 Synthesis of [PAF] in *response* to was also detected in rat polymorphonuclear neutrophils , but not in human tumor cells and dermal fibroblasts . Regulation CTR9 TNF 3261295 95998 About 30 % of [PAF] produced in *response* to either or IL-1 is released into the medium , whereas approximately 70 % remains cell associated . Regulation CTR9 TNF 3261295 96012 Experiments with labeled precursors show that [PAF] is synthesized de novo in *response* to . Regulation CTR9 TNF 3261295 96023 This suggests that [PAF] is synthesized by the same pathway in *response* to or IL-1 . Regulation CTR9 TNF 8488366 219198 In contrast to its effect on the AA turnover , did not *affect* the phospholipase C-stimulated production of platelet activating factor ( [PAF-acether] ) . Regulation CTR9 TNF 9187959 437081 GM-CSF production by EC was also stimulated by the combined effects of PAF and , but [PAF] alone did not *affect* GM-CSF production . Regulation CTSB CST6 14678520 1178969 *Regulation* of [cathepsin B] and L expression in vitro in gastric cancer tissues by egg . Regulation CTSB IL1B 2176623 147017 *Effect* of on the production of [cathepsin B] by rabbit articular chondrocytes . Regulation CTSB IL1B 8636387 358105 In contrast , has a stimulatory influence on the generation of the amyloidogenic 41-kDa APP metabolite , but does not *affect* the cellular holoprotein or [APPs] . Regulation CTSB IL1B 8645703 363326 [Cathepsin B] activity and its *regulation* by and parathyroid hormone (PTH) was investigated in normal human osteoblast-like cells ( hOB ) and in the human osteoblastic osteosarcoma cell line MG-63 . Regulation CTSB IL1B 9068283 419020 Chondrocyte monolayers were used to determine [cathepsin-B] expression in *response* to . Regulation CTSB TNF 9767364 538602 These findings indicate that , except for *regulation* of the negative [APPs] by , the mechanism of APP regulation is different under the conditions of the short-term and the chronic , long lasting ` acute-phase reaction ' . Regulation CTSD TNF 14739942 1235042 Ectopic expression of [CTSD] in CTSD-deficient fibroblasts results in an enhanced mediated apoptotic *response* . Regulation CTSG TNF 7499869 336096 In this study , we describe expression of neutrophil cell surface bound [cathepsin G] in *response* to and platelet activating factor (PAF) under conditions in which minimal free release of cathepsin G is detected . Regulation CTSK IL1B 11920402 926108 To determine and compare the expression of cathepsins K and S proteins in joints with rheumatoid arthritis ( RA ) and osteoarthritis ( OA ) and to determine the *effect* of and tumor necrosis factor alpha (TNF alpha) on the expression of [cathepsin K] in fibroblast-like synoviocytes . Regulation CTSK IL1B 11920402 926110 The *effect* of and TNF alpha on the expression and secretion of [cathepsin K] in primary cultures of synoviocytes was determined by real-time polymerase chain reaction and Western blot analysis . Regulation CTSK TNF 11269728 797353 IL-6 and did not significantly *affect* [cathepsin K] gene expression in osteoclasts . Regulation CTSK TNF 11920402 926107 To determine and compare the expression of cathepsins K and S proteins in joints with rheumatoid arthritis ( RA ) and osteoarthritis ( OA ) and to determine the *effect* of interleukin-1 beta (IL-1 beta) and on the expression of [cathepsin K] in fibroblast-like synoviocytes . Regulation CTSK TNF 11920402 926109 The *effect* of IL-1 beta and on the expression and secretion of [cathepsin K] in primary cultures of synoviocytes was determined by real-time polymerase chain reaction and Western blot analysis . Regulation CTSL CST6 16874311 1672481 Recently , we provided biochemical evidence that human cathepsin V (CTSV) and [cathepsin L (CTSL)] are additional biological *targets* for human . Regulation CTSL CST6 19262604 2072722 directly *controls* the activity of cathepsin V , [cathepsin L] , and legumain , thereby regulating the processing of transglutaminases . Regulation CTSL FOXO1 20088826 2218953 In the present study , we conducted in vivo and in vitro experiments focusing on *regulation* of [Ctsl] ( cathepsin L gene ; CTSL1 in humans ) expression in the skeletal muscle . Regulation CTSL TNF 15516323 1328535 We used RT-PCR to examine the *effects* of on bone sialoprotein ( BSP ) , core binding factor a1 (Cbfa1) , osterix , alpha 1 ( I ) collagen , cyclooxygenase-2 (COX-2) , interleukin-6 (IL-6) , cathepsin B , [cathepsin L] and tissue inhibitors of metalloproteinase-1 ( TIMP-1 ) . Regulation CTSS CAPN8 23515028 2799593 The Ca²? *dependent* , isoforms 1 and 2 , but not [cathepsins] , were proven crucial for the altered AIF behaviour as studied by the pharmacological inhibitor and the knockdown approaches . Regulation CTSV CST6 16874311 1672482 Recently , we provided biochemical evidence that human [cathepsin V (CTSV)] and cathepsin L (CTSL) are additional biological *targets* for human . Regulation CTSV CST6 19262604 2072723 directly *controls* the activity of [cathepsin V] , cathepsin L , and legumain , thereby regulating the processing of transglutaminases . Regulation CTSV CST6 20495178 2319865 Biochemical evidence suggests that *controls* the activity of legumain , cathepsin L , [cathepsin V] , and transglutaminase-3 . Regulation CTTN CCND1 16536875 1549473 is *involved* in cell cycle regulation and the F-actin binding protein [cortactin] in cytoskeletal dynamics and cell migration . Regulation CUL1 IL1B 16407046 1513310 We investigated whether HDSMCs are capable of expressing and releasing MCP-1 , IL-6 and [SCF] in *response* to IL-4 , IL-13 , and tumor necrosis factor-alpha . Regulation CUL1 IL1B 16584593 1544094 there were not *effects* of expression on expressions of IL-6 and [SCF] . Regulation CUL1 TNF 10067879 594040 Activin , TGF beta , TGF alpha , and had no *effect* on [SCF] gene expression in vitro . Regulation CUL1 TNF 16407046 1513309 We investigated whether HDSMCs are capable of expressing and releasing MCP-1 , IL-6 and [SCF] in *response* to IL-4 , IL-13 , IL-1beta and . Regulation CUL1 TNF 23662587 2805507 Comparison of the stimulatory *effects* of interleukin (IL)-1a or on [SCF] production between SK cells and NHK demonstrated that SK cells do not respond to IL-1a or TNF-a to stimulate production of SCF , whereas a significant stimulation of SCF is elicited by those same cytokines in NHK . Regulation CX3CL1 CTGF 16408113 1513392 The present studies investigate the regulatory *role* of in the production of [fractalkine] , monocyte chemoattractant protein-1 ( MCP-1 ) , and RANTES ( regulated upon activation , normal T cell expressed and secreted ) in cultured mesangial cells of rats , and the modulatory effects of lipoxin A ( 4 ) ( LXA ( 4 ) ) on actions of CTGF . Regulation CX3CL1 TNF 11777952 899779 [Fractalkine] is expressed by smooth muscle cells in *response* to IFN-gamma and and is modulated by metalloproteinase activity . Regulation CX3CL1 TNF 12631113 1067662 The present data indicate that activation of PKCzeta/iota , p42/44 MAPK , c-Jun/AP-1 , and p65/NF-kappaB are *involved* in TNF-alpha stimulated MC [fractalkine] expression , with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro . Regulation CX3CL1 TNF 15013759 1220694 and IL-4 *regulate* expression of [fractalkine] ( CX3CL1 ) as a membrane anchored proadhesive protein and soluble chemotactic peptide on human fibroblasts . Regulation CX3CL1 TNF 20231691 2237883 CX3CL1 expression is under control of posttranscriptional regulation , which is involved in the synergistic induction of [CX3CL1] in *response* to the combined stimulation with and IFN-gamma . Regulation CX3CL1 TNF 23117657 2717525 The use of small interfering RNA revealed the *involvement* of in Ang-II induced [CX(3)CL1] upregulation and mononuclear cell arrest . Regulation CXADR MAP2K6 21791114 2472516 We have previously reported that ( Cancer Res. 2003 May 1 ; 63 ( 9 ) : 2088-95 ) and TGF-ß ( Cancer Res. 2006 Feb 1 ; 66 ( 3 ) : 1648-57 ) signaling negatively *regulate* [coxsackie virus and adenovirus receptor] ( CAR ) cell-surface expression and adenovirus uptake . Regulation CXADR TNF 24478392 2923420 Synergistic *effect* of interferon-gamma and on [coxsackievirus and adenovirus receptor] expression : an explanation of cell sloughing during testicular inflammation in mice . Regulation CXCL1 RNF150 20648642 2293007 Using a panel of kinase inhibitors , we demonstrated that NOV action on CCL2 and [CXCL1] production *involved* a and a Rho/qROCK/p38/NF-kappaB pathway , respectively . Regulation CXCL1 TNF 18198355 1883760 The [FSP27] transcript is inversely *regulated* by and insulin , consistent with an antilipolytic function . Regulation CXCL1 TNF 19353522 2064853 C/EBPbeta knockdown also inhibited the synergistic expression of [CXCL1] , inducible nitric oxide synthase , and CCL5 in *response* to concomitant IFNgamma and . Regulation CXCL1 TNF 20720199 2313006 In vitro , macrophages from IRF3-deficient mice showed complete inhibition of CCL5 ( RANTES ) and CXCL10 ( IP-10 ) production , partial inhibition of , but no *effect* on CXCL2 ( MIP-2 ) or [CXCL1] ( keratinocyte derived chemokine ) in response to P. aeruginosa stimulation . Regulation CXCL1 TNF 22976954 2693599 The synergistic *effect* of and IL-17A on astrocytes resulted in enhanced secretion of [CXCL-1] , a neutrophil chemoattractant . Regulation CXCL1 TNF 24186876 2890168 NADPH oxidase mediates synergistic *effects* of IL-17 and on [CXCL1] expression by epithelial cells after lung ischemia-reperfusion . Regulation CXCL1 TNF 8264646 247048 IL-1 and posttranscriptionally *regulate* [MGSA/GRO] mRNA levels in both cell types . Regulation CXCL10 EPHB2 17617806 1769768 The suppressive effect on MDC and [IP-10] may , at least in part , *involve* the down-regulation of LPS induced p38 and expression . Regulation CXCL10 IL1B 18046562 1852434 NF-kappaB dependent synergistic *regulation* of [CXCL10] gene expression by and IFN-gamma in human intestinal epithelial cell lines . Regulation CXCL10 IL1B 18046562 1852436 These data demonstrate that in colonic epithelial cells , depending on the cellular context and utilizing the NF-kappaB pathway , alone and/or in synergism with IFN-gamma may *play* a major role in the induction of [CXCL10] . Regulation CXCL10 TNF 12578855 1058252 Although IP-10 mRNA expression was abrogated in TNF-alpha ( -/- ) mice , both CHS development and TNF-alpha mRNA expression occurred normally in IFN-gamma ( -/- ) mice , indicating that the induction of [IP-10] during CHS was primarily *controlled* by . Regulation CXCL10 TNF 17328963 1726375 Molecular characterization of cDNA encoding porcine IP-10 and induction of porcine endothelial [IP-10] in *response* to human . Regulation CXCL10 TNF 19755523 2163442 The combined *effects* of interferon gamma (IFNgamma) and stimulation on [CXCL10] secretion in primary cells from PTCs and TFC were tested . Regulation CXCL10 TNF 22422499 2588061 In contrast , the synergistic *effect* of IFN-? and on [CXCL10] secretion was similar in SSc fibroblasts and in controls . Regulation CXCL10 TNF 9681518 521336 Conversely , [IP-10] mRNA levels were markedly increased in *response* to murine interleukin-1alpha , murine , and murine IFNgamma by 3.3- , 10- , and 26-fold , respectively . Regulation CXCL11 MUC16 16466101 1523375 We studied the *role* of cytokeratin ( CK ) and expression in differentiating [ITAC] , metastatic adenocarcinoma of intestinal origin , and non-intestinal-type sinonasal adenocarcinoma ( non-ITAC ) . Regulation CXCL11 TNF 18987152 2015282 Furthermore , HCV can selectively increase [CXCL11] expression in *response* to IFN-gamma and stimulation that may play a role in the pathogenesis of HCV related liver disease . Regulation CXCL12 EPHB2 17169599 1688014 The OSM stimulated expression of SDF-1 in hATSCs was completely abrogated by pretreatment of the cells with U0126 , an MEK-specific inhibitor , but not with AG490 , a JAK2 inhibitor , or WHI-P131 , a JAK3 inhibitor , suggesting that , but not JAK2 and JAK3 , is *involved* in the OSM induced expression of [SDF-1] . Regulation CXCL12 IL1B 11673556 872891 On the other hand , CCL2 , CCL5 , and [CXCL12] were expressed on RA FLS , and their production was *regulated* by TNF-alpha , , and TGF-beta1 . Regulation CXCL12 PLAU 21465475 2523645 The *effect* of on SK-Hep-1 signaling and [SDF-1] expression is mediated by uPAR . Regulation CXCL12 TNF 11673556 872890 On the other hand , CCL2 , CCL5 , and [CXCL12] were expressed on RA FLS , and their production was *regulated* by , IL-1beta , and TGF-beta1 . Regulation CXCL16 EPHB2 15883016 1406563 Thus , our data indicate that [CXCL16] may act as a novel angiogenic factor for HUVEC and that is *involved* as an important signaling molecule to mediate its angiogenic effects . Regulation CXCL16 TNF 16508941 1530323 Interestingly , RA ST fibroblasts did not produce [CXCL16] in *response* to in vitro , suggesting that CXCL16 protein may function in large part independently of TNFalpha . Regulation CXCL2 TNF 16771850 1572689 However , it remains elusive whether enterocytes release [CXCL2] in *response* to LPS and via a NF-kappaB dependent pathway and whether this involves the endogenous production of TNF and PAF . Regulation CXCL2 TNF 16771850 1572698 In conclusion , [CXCL2] gene is expressed in enterocytes in *response* to both and LPS . Regulation CXCL2 TNF 20720199 2313009 In vitro , macrophages from IRF3-deficient mice showed complete inhibition of CCL5 ( RANTES ) and CXCL10 ( IP-10 ) production , partial inhibition of , but no *effect* on [CXCL2] ( MIP-2 ) or CXCL1 ( keratinocyte derived chemokine ) in response to P. aeruginosa stimulation . Regulation CXCL2 TNF 24479486 2918450 Importantly , we observed pronounced *effects* of ß2-adrenergic receptor agonists and on IL-6 , [CXCL2] , CXCL3 , VCAM1 , and ICAM1 expression , suggesting a role in inflammatory brain cell homeostasis . Regulation CXCL5 IL1B 1744577 171913 In *response* to stimulation with either or tumor necrosis factor alpha (TNF-alpha) , [ENA-78] was produced and secreted concomitantly with IL-8 , GRO alpha , and GRO gamma . Regulation CXCL5 TNF 12882792 1116329 [ENA-78] gene expression is significantly enhanced in both HCECs and HCKs in *response* to either IL-1alpha or stimulation . Regulation CXCL5 TNF 1744577 171912 In *response* to stimulation with either interleukin 1 beta (IL-1 beta) or , [ENA-78] was produced and secreted concomitantly with IL-8 , GRO alpha , and GRO gamma . Regulation CXCL5 TNF 7814607 292698 These findings support the notion that pulmonary [ENA-78] produced in *response* to hepatic derived is an important mediator of lung injury . Regulation CXCL5 TNF 8961388 402324 ENA-78 levels were significantly decreased in the animals receiving the anti-TNF serum , suggesting that [ENA-78] is released in *response* to in this model . Regulation CXCL6 TNF 12524079 1047844 The *effects* of interleukin (IL)-1alpha , IL-1beta , , TNF-beta , interferon (IFN)-gamma , and lipopolysaccharide (LPS) on the production of [GCP-2] by endometrial stromal cells were investigated . Regulation CXCL9 TNF 11696601 877517 *dependent* segmental control of [MIG] expression by high endothelial venules in inflamed lymph nodes regulates monocyte recruitment . Regulation CXCR1 F2R 18657231 2175651 The *effect* of stimulation by the peptide SFLLRN on IL-8 , [CXCR1] and CXCR2 expression was examined by RTQ-PCR and at the protein level in AB and CB late EPC and in AB early EPC . Regulation CXCR1 TNF 10090924 600284 Metalloproteinases are involved in lipopolysaccharide- and mediated *regulation* of [CXCR1] and CXCR2 chemokine receptor expression . Regulation CXCR1 TNF 9574558 502544 In contrast , [CXCR1] expression was not *affected* by . Regulation CXCR2 F2R 18657231 2175652 The *effect* of stimulation by the peptide SFLLRN on IL-8 , CXCR1 and [CXCR2] expression was examined by RTQ-PCR and at the protein level in AB and CB late EPC and in AB early EPC . Regulation CXCR2 TLR7 21281976 2419788 Collectively , it is suggested that commensals promote migration of mast cells into the intestine through the induction of [CXCR2] ligands from IECs in a *dependent* manner . Regulation CXCR2 TNF 10090924 600285 Metalloproteinases are involved in lipopolysaccharide- and mediated *regulation* of CXCR1 and [CXCR2] chemokine receptor expression . Regulation CXCR2 TNF 16429233 1534092 Cellular activity of IL8 is mediated by the receptor [CXCR2] , and transcription of IL8 is *controlled* by the cytokine tumour necrosis factor ( ) . Regulation CXCR2 TNF 18462836 2185383 These data suggest that [CXCR2] overexpression in peripheral T cells is intracerebral microglial *dependent* and TNF-alpha primes T cells transendothelial migration in Alzheimer 's diseases . Regulation CXCR3 TNF 20579746 2290585 *dependent* regulation of [CXCR3] expression modulates neuronal survival during West Nile virus encephalitis . Regulation CXCR4 IL1B 11160334 781700 The peak of [CXCR4] expression in *response* to TNF-alpha and was 8 and 4 h , respectively . Regulation CXCR4 PTGER2 20705717 2363462 Using an in vitro model system of Ishikawa endometrial epithelial cells stably expressing PTGER2 and human first trimester decidua explants , we demonstrate that [CXCR4] expression is *regulated* by via the epidermal growth factor receptor (EGFR)-phosphatidylinositol-3-kinase (PI3K)-extracellular signal regulated kinase ( ERK1/2 ) pathway . Regulation CXCR4 SELL 21460863 2448200 Sulfatide , one of the native ligands for L-selectin , induced the increase of surface CXCR4 expression on isolated circulating neutrophils , suggesting that the activation of may be *involved* in the increase in surface [CXCR4] . Regulation CXCR4 SELL 22808501 2629012 *Effects* of stimulation of the expression of chemokine receptor [CXCR4] on NK cells of healthy donors and tumor patients . Regulation CXCR4 TNF 10195234 561032 Although treatment of PBMCs with interferon-alpha (IFN-alpha) and IFN-gamma led to a significant repression of CXCR4 gene expression , interleukin-1 beta (IL-1 beta) , IL-6 , and had no significant *effect* on [CXCR4] gene expression in PBMCs . Regulation CXCR4 TNF 11160334 781699 The peak of [CXCR4] expression in *response* to and IL-1beta was 8 and 4 h , respectively . Regulation CXCR4 TNF 12555203 1051617 Expression of chemokines and their receptors in human and simian astrocytes : evidence for a central *role* of and IFN gamma in [CXCR4] and CCR5 modulation . Regulation CXCR4 TNF 14550764 1152793 Cyclic AMP and *regulate* [CXCR4] gene expression in Schwann cells . Regulation CXCR4 TNF 14579271 1156728 Tauhe down-modulation of [CXCR4] surface expression in *response* to and IFN-gamma was fully reversible after cytokine removal . Regulation CXCR4 TNF 20699000 2312289 *Involvement* of in the upregulation of [CXCR4] expression in gastric cancer induced by Helicobacter pylori . Regulation CYBA TNF 12807699 1185280 p22phox antisense oligonucleotide prevented the induced *effect* on [p22phox] , p47phox , O2-* , and permeability . Regulation CYBB TLR7 15994412 1447033 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for tumor necrosis factor ( TNF-alpha ) , interleukin 6 , nitric oxide synthase-II ( iNOS ) , and [NADPH oxidase 2 (Nox2)] . Regulation CYBB TLR7 23386616 2754994 In this study , we investigated the *role* of in [Nox2] expression in spinal cord microglia after peripheral nerve injury . Regulation CYBB TNF 14769150 1182382 The aim of this study was to investigate the *effect* of interferon-gamma (IFN-gamma) and on NADPH oxidase activity and [gp91-phox] gene expression in HL-60 clone 15 cells as they differentiate along the eosinophilic lineage . Regulation CYBB TNF 16181054 1461869 The aim of this work was to analyze the *effect* of Interferon-gamma (IFN-gamma) and on NADPH oxidase activity and [gp91-phox] gene expression in human colostrum macrophages ( CM ) , peripheral blood monocytes ( PBM ) , and myelomonocytic THP-1 cells . Regulation CYCS IL1B 17678971 1777413 In conclusion , we report the original observation that neuroprotection exerted by 17beta-E ( 2 ) in a rat model of transient focal brain ischemia is accompanied by reduced [cytochrome c] translocation to the cytosol and *involves* early modulation of production . Regulation CYCS MMP28 16776320 1496725 Mitochondrial , delta ( phi ) m , may control the permeability of the outer membrane and *regulate* [cytochrome c] release . Regulation CYCS MMP7 16776320 1496740 Mitochondrial , delta ( phi ) m , may control the permeability of the outer membrane and *regulate* [cytochrome c] release . Regulation CYCS TNF 10846176 715222 Subsequently , both the decrease in Bcl-2 protein levels and the mitochondrial release of [cytochrome c] in *response* to were largely prevented by exogenous NO . Regulation CYCS TNF 12869386 1149975 SP-600125 , a specific inhibitor of JNK activation , prevented [cytochrome c] release from mitochondria , JNK activation , DNA fragmentation , and caspase-9 activation in *response* to . Regulation CYCS TNFSF10 10760520 683616 Thus , engages a death pathway that is at least partially routed via the mitochondria , but in contrast with other stimuli that engage this pathway , TRAIL induced [cytochrome c] release is not *regulated* by Bcl-2 . Regulation CYLD PDE4B 23575688 2768174 Moreover , negatively *regulates* [CYLD] via specific activation of JNK2 but not JNK1 . Regulation CYP11A1 TNF 9397943 291197 We next evaluated the *effect* of on [P450scc] gene expression . Regulation CYP11B2 VSNL1 22331379 2571836 These data demonstrate that *plays* a dual function in vitro in the regulation of [CYP11B2] gene expression and in the inhibition of calcium induced apoptosis . Regulation CYP17A1 NR2F1 14765993 1207495 Overexpression of Ubc9 similarly enhances *dependent* repression of the promoter activity of the bovine [CYP17] gene encoding steroid 17alpha-hydroxylase . Regulation CYP17A1 TNF 7628389 316410 To examine the mechanism of TNF alpha mediated inhibition of steroidogenesis , the *effect* of on cAMP stimulated induction of [Cyp17] expression was investigated . Regulation CYP17A1 TNF 7628389 316419 PMA , a known activator of PKC , and had a similar inhibitory *effect* on [P450c17] expression , testosterone production , and Cyp17-CAT activity . Regulation CYP17A1 TNF 8504748 221285 The inhibitory *effect* of on 8-Br-cAMP induced [P450c17] mRNA expression was reversible . Regulation CYP19A1 IL1B 10652212 662806 *Effect* of on [aromatase] activity and cell proliferation in human osteoblast-like cells (HOS) . Regulation CYP19A1 IL1B 10652212 662807 In the present study , the *effect* of on [aromatase (Arom)] activity in human osteoblast-like cells (HOS) was investigated . Regulation CYP19A1 IL1B 11165036 782713 Despite the presence of inhibitors of protein kinase C ( staurosporine ) or tyrosine kinases ( genistein ) , the inhibitory *effects* of TNFalpha and on the Forskoline induced expression of 17HSD type 1 and [P450arom] and the Forskoline induced 17HSD activity were not blocked . Regulation CYP19A1 IL1B 12411029 1010666 [ *Effect* of on [aromatase] activity in human osteoblast-like cells ] . Regulation CYP19A1 IL1B 12411029 1010667 In the present study , the *effect* of and IL-1ra on [aromatase (Arom)] activity and mRNA expression in human osteoblast-like cells was investigated by [ ( 3 ) H ] water released upon the conversion of [ 1beta- ( 3 ) H ] androstenedione to estrone and the reverse-transcription polymerase cain reaction ( RT-PCR ) method . Regulation CYP19A1 IL1B 1646737 157919 Neither IL-1 alpha nor had any *effect* on basal [aromatase] activity . Regulation CYP19A1 IL1B 2503616 115241 These results suggest that may *play* some role in the multifactorial regulation of [aromatase] and estrogen secretion in the early developing follicle , and IL-1 beta may exert an effect on the cAMP-adenylate cyclase messenger system in granulosa cells . Regulation CYP19A1 IL1B 8782659 380463 *Regulation* of arachidonic acid metabolism , [aromatase] activity and growth in human breast cancer cells by and phorbol ester : dissociation of a mediatory role for prostaglandin E2 in the autocrine control of cell function . Regulation CYP19A1 IL1B 9024261 413331 The *effects* of , IL-2 , IL-6 , IL-11 , oncostatin M , IL-15 , tumor necrosis factor-alpha , PGE2 , estradiol , R5020 , dexamethasone , and dibutyryl cAMP ( Bt2cAMP ) on [aromatase] activity in endometriosis derived stromal cells were assessed . Regulation CYP19A1 PGC 24654751 2942823 To investigate the *effect* of on [aromatase] activity in endometriosis . Regulation CYP19A1 PGC 24654751 2942825 *dependent* changes in [aromatase] expression in primary cultured stromal cells ( SCs ) were identified using luciferase and enzymatic assays , exon I-specific RT-PCR , and real-time PCR . Regulation CYP19A1 PTGER2 17614108 1774770 PGE ( 2 ) receptor , EP(1) , and EP(4) were *involved* in the up-regulation of [aromatase] activity in response to PGE ( 2 ) in a Dex dependent manner . Regulation CYP19A1 SLCO2A1 21212407 2386310 The *regulates* adipogenesis and [aromatase] transcription . Regulation CYP19A1 SLCO2A1 21212407 2386312 The main objective of this study was to determine whether *regulates* [CYP19] transcription . Regulation CYP19A1 TF 1744571 171908 The *effect* of on basal and FSH stimulated [aromatase] activity of granulosa cells from immature female rats treated with diethylstilboestrol (DES) was examined in vitro by a radiometric method . Regulation CYP19A1 TF 1744571 171909 A time-course study showed that the inhibitory *effect* of on [aromatase] activity has become significant at 48 h of incubation . Regulation CYP19A1 TNF 11165036 782712 Despite the presence of inhibitors of protein kinase C ( staurosporine ) or tyrosine kinases ( genistein ) , the inhibitory *effects* of and IL-1beta on the Forskoline induced expression of 17HSD type 1 and [P450arom] and the Forskoline induced 17HSD activity were not blocked . Regulation CYP19A1 TNF 14623530 1169920 Furthermore in PS a synergistic *effect* of Dex and on [P450arom] mRNA expression was observed whereas an additive one was recorded for RS . Regulation CYP19A1 TNF 3132919 94247 The *effect* of on follicle stimulating hormone induced [aromatase] activity in cultured rat granulosa cells . Regulation CYP19A1 TNF 3132919 94248 We investigated the *effects* of on follicle stimulating hormone ( FSH ) -induced [aromatase] activity in cultured rat granulosa cells using the stereospecific transfer of 3H from [ 1 beta-3H ] androstenedione into 3H2O . Regulation CYP19A1 TNF 7720683 301488 Ceramide mediates *effects* on [P450-aromatase] activity in cultured granulosa cells . Regulation CYP19A1 TNF 9024261 413330 The *effects* of interleukin-1 beta (IL-1 beta) , IL-2 , IL-6 , IL-11 , oncostatin M , IL-15 , , PGE2 , estradiol , R5020 , dexamethasone , and dibutyryl cAMP ( Bt2cAMP ) on [aromatase] activity in endometriosis derived stromal cells were assessed . Regulation CYP1A1 IL1B 9345309 459372 Differential *effects* of , interleukin-2 , and interferon-gamma on the inducible expression of [CYP 1A1] and CYP 1A2 in cultured rabbit hepatocytes . Regulation CYP1A2 IL1B 9345309 459375 Differential *effects* of , interleukin-2 , and interferon-gamma on the inducible expression of CYP 1A1 and [CYP 1A2] in cultured rabbit hepatocytes . Regulation CYP24A1 CALCA 14765994 1207496 A GC box at -114/-101 and a CCAAT box at -62/-51 have been identified that underlie both basal expression of the [CYP24] promoter and the inductive *response* . Regulation CYP24A1 CAPN1 15225804 1268456 Additionally , modulation of cell proliferation by inhibitors , as well as *regulation* of mRNA expression of VDR , 1alpha-OHase , and [24-OHase] genes by Vitamin D analogs were assessed in melanoma cell lines in vitro using a WST-1 based colorimetric assay and real-time PCR , respectively . Regulation CYP24A1 CAPN10 15225804 1268457 Additionally , modulation of cell proliferation by inhibitors , as well as *regulation* of mRNA expression of VDR , 1alpha-OHase , and [24-OHase] genes by Vitamin D analogs were assessed in melanoma cell lines in vitro using a WST-1 based colorimetric assay and real-time PCR , respectively . Regulation CYP24A1 CAPN11 15225804 1268458 Additionally , modulation of cell proliferation by inhibitors , as well as *regulation* of mRNA expression of VDR , 1alpha-OHase , and [24-OHase] genes by Vitamin D analogs were assessed in melanoma cell lines in vitro using a WST-1 based colorimetric assay and real-time PCR , respectively . Regulation CYP24A1 CAPN12 15225804 1268455 Additionally , modulation of cell proliferation by inhibitors , as well as *regulation* of mRNA expression of VDR , 1alpha-OHase , and [24-OHase] genes by Vitamin D analogs were assessed in melanoma cell lines in vitro using a WST-1 based colorimetric assay and real-time PCR , respectively . Regulation CYP24A1 CAPN13 15225804 1268466 Additionally , modulation of cell proliferation by inhibitors , as well as *regulation* of mRNA expression of VDR , 1alpha-OHase , and [24-OHase] genes by Vitamin D analogs were assessed in melanoma cell lines in vitro using a WST-1 based colorimetric assay and real-time PCR , respectively . Regulation CYP24A1 CAPN14 15225804 1268467 Additionally , modulation of cell proliferation by inhibitors , as well as *regulation* of mRNA expression of VDR , 1alpha-OHase , and [24-OHase] genes by Vitamin D analogs were assessed in melanoma cell lines in vitro using a WST-1 based colorimetric assay and real-time PCR , respectively . Regulation CYP24A1 CAPN15 15225804 1268454 Additionally , modulation of cell proliferation by inhibitors , as well as *regulation* of mRNA expression of VDR , 1alpha-OHase , and [24-OHase] genes by Vitamin D analogs were assessed in melanoma cell lines in vitro using a WST-1 based colorimetric assay and real-time PCR , respectively . Regulation CYP24A1 CAPN2 15225804 1268459 Additionally , modulation of cell proliferation by inhibitors , as well as *regulation* of mRNA expression of VDR , 1alpha-OHase , and [24-OHase] genes by Vitamin D analogs were assessed in melanoma cell lines in vitro using a WST-1 based colorimetric assay and real-time PCR , respectively . Regulation CYP24A1 CAPN3 15225804 1268460 Additionally , modulation of cell proliferation by inhibitors , as well as *regulation* of mRNA expression of VDR , 1alpha-OHase , and [24-OHase] genes by Vitamin D analogs were assessed in melanoma cell lines in vitro using a WST-1 based colorimetric assay and real-time PCR , respectively . Regulation CYP24A1 CAPN5 15225804 1268461 Additionally , modulation of cell proliferation by inhibitors , as well as *regulation* of mRNA expression of VDR , 1alpha-OHase , and [24-OHase] genes by Vitamin D analogs were assessed in melanoma cell lines in vitro using a WST-1 based colorimetric assay and real-time PCR , respectively . Regulation CYP24A1 CAPN6 15225804 1268462 Additionally , modulation of cell proliferation by inhibitors , as well as *regulation* of mRNA expression of VDR , 1alpha-OHase , and [24-OHase] genes by Vitamin D analogs were assessed in melanoma cell lines in vitro using a WST-1 based colorimetric assay and real-time PCR , respectively . Regulation CYP24A1 CAPN7 15225804 1268463 Additionally , modulation of cell proliferation by inhibitors , as well as *regulation* of mRNA expression of VDR , 1alpha-OHase , and [24-OHase] genes by Vitamin D analogs were assessed in melanoma cell lines in vitro using a WST-1 based colorimetric assay and real-time PCR , respectively . Regulation CYP24A1 CAPN8 15225804 1268464 Additionally , modulation of cell proliferation by inhibitors , as well as *regulation* of mRNA expression of VDR , 1alpha-OHase , and [24-OHase] genes by Vitamin D analogs were assessed in melanoma cell lines in vitro using a WST-1 based colorimetric assay and real-time PCR , respectively . Regulation CYP24A1 CAPN9 15225804 1268465 Additionally , modulation of cell proliferation by inhibitors , as well as *regulation* of mRNA expression of VDR , 1alpha-OHase , and [24-OHase] genes by Vitamin D analogs were assessed in melanoma cell lines in vitro using a WST-1 based colorimetric assay and real-time PCR , respectively . Regulation CYP24A1 MAPK1 18467787 1910199 [CYP24] promoter activity is *affected* by mechanical stress and in MG63 osteoblast-like cells . Regulation CYP24A1 MAPK1 18467787 1910212 In this study we investigated CYP24 promoter activity in stretched osteoblastic cells and the *participation* of in expression of [CYP24] . Regulation CYP24A1 MAPK10 18467787 1910200 [CYP24] promoter activity is *affected* by mechanical stress and in MG63 osteoblast-like cells . Regulation CYP24A1 MAPK10 18467787 1910213 In this study we investigated CYP24 promoter activity in stretched osteoblastic cells and the *participation* of in expression of [CYP24] . Regulation CYP24A1 MAPK11 18467787 1910201 [CYP24] promoter activity is *affected* by mechanical stress and in MG63 osteoblast-like cells . Regulation CYP24A1 MAPK11 18467787 1910214 In this study we investigated CYP24 promoter activity in stretched osteoblastic cells and the *participation* of in expression of [CYP24] . Regulation CYP24A1 MAPK12 18467787 1910202 [CYP24] promoter activity is *affected* by mechanical stress and in MG63 osteoblast-like cells . Regulation CYP24A1 MAPK12 18467787 1910215 In this study we investigated CYP24 promoter activity in stretched osteoblastic cells and the *participation* of in expression of [CYP24] . Regulation CYP24A1 MAPK13 18467787 1910203 [CYP24] promoter activity is *affected* by mechanical stress and in MG63 osteoblast-like cells . Regulation CYP24A1 MAPK13 18467787 1910216 In this study we investigated CYP24 promoter activity in stretched osteoblastic cells and the *participation* of in expression of [CYP24] . Regulation CYP24A1 MAPK14 18467787 1910204 [CYP24] promoter activity is *affected* by mechanical stress and in MG63 osteoblast-like cells . Regulation CYP24A1 MAPK14 18467787 1910217 In this study we investigated CYP24 promoter activity in stretched osteoblastic cells and the *participation* of in expression of [CYP24] . Regulation CYP24A1 MAPK15 18467787 1910198 [CYP24] promoter activity is *affected* by mechanical stress and in MG63 osteoblast-like cells . Regulation CYP24A1 MAPK15 18467787 1910211 In this study we investigated CYP24 promoter activity in stretched osteoblastic cells and the *participation* of in expression of [CYP24] . Regulation CYP24A1 MAPK3 18467787 1910205 [CYP24] promoter activity is *affected* by mechanical stress and in MG63 osteoblast-like cells . Regulation CYP24A1 MAPK3 18467787 1910218 In this study we investigated CYP24 promoter activity in stretched osteoblastic cells and the *participation* of in expression of [CYP24] . Regulation CYP24A1 MAPK4 18467787 1910206 [CYP24] promoter activity is *affected* by mechanical stress and in MG63 osteoblast-like cells . Regulation CYP24A1 MAPK4 18467787 1910219 In this study we investigated CYP24 promoter activity in stretched osteoblastic cells and the *participation* of in expression of [CYP24] . Regulation CYP24A1 MAPK6 18467787 1910207 [CYP24] promoter activity is *affected* by mechanical stress and in MG63 osteoblast-like cells . Regulation CYP24A1 MAPK6 18467787 1910220 In this study we investigated CYP24 promoter activity in stretched osteoblastic cells and the *participation* of in expression of [CYP24] . Regulation CYP24A1 MAPK7 18467787 1910208 [CYP24] promoter activity is *affected* by mechanical stress and in MG63 osteoblast-like cells . Regulation CYP24A1 MAPK7 18467787 1910221 In this study we investigated CYP24 promoter activity in stretched osteoblastic cells and the *participation* of in expression of [CYP24] . Regulation CYP24A1 MAPK8 18467787 1910209 [CYP24] promoter activity is *affected* by mechanical stress and in MG63 osteoblast-like cells . Regulation CYP24A1 MAPK8 18467787 1910222 In this study we investigated CYP24 promoter activity in stretched osteoblastic cells and the *participation* of in expression of [CYP24] . Regulation CYP24A1 MAPK9 18467787 1910210 [CYP24] promoter activity is *affected* by mechanical stress and in MG63 osteoblast-like cells . Regulation CYP24A1 MAPK9 18467787 1910223 In this study we investigated CYP24 promoter activity in stretched osteoblastic cells and the *participation* of in expression of [CYP24] . Regulation CYP24A1 MYLIP 19570947 2136713 Human [CYP24] catalyzing the inactivation of calcitriol is post-transcriptionally *regulated* by . Regulation CYP24A1 MYLIP 19570947 2136715 We investigated whether [CYP24] is *regulated* by . Regulation CYP24A1 MYLIP 19570947 2136717 These results suggested that human [CYP24] is *regulated* by . Regulation CYP24A1 MYLIP 19570947 2136719 In conclusion , this study clearly demonstrates that post-transcriptionally *regulates* the [CYP24] , which serves as a possible mechanism for the high CYP24 expression in cancer tissues . Regulation CYP24A1 PTH 10198318 605186 The stimulatory *effect* of cAMP or on [24OHase] expression in DCT cells suggests differential regulation of 24OHase expression in the PCT and DCT . Regulation CYP24A1 PTH 9681485 521187 alone had no *effect* on [CYP24] mRNA levels , and 1,25 ( OH ) 2D alone produced only a modest increase . Regulation CYP24A1 SIL1 19244278 2062606 Treatment of cells with an AhR antagonist and a protein synthesis inhibitor inhibited the enhancing *effect* of on [CYP24A1] induction , indicating that the effects of BaP are mediated by AhR activation and de novo protein synthesis . Regulation CYP24A1 TNF 19501915 2103003 The *effects* of on [CYP24A1] , chorionic gonadotropin ( hCG ) , 3beta-hydroxysteroid dehydrogenase ( HSD3B1 ) and P ( 450 ) -aromatase ( CYP19 ) mRNA expression were also studied . Regulation CYP24A1 VDR 16598763 1604404 Transfection studies in CaCo-2 cells with a vitamin D response element containing construct revealed the *involvement* of the in this UVB dependent [CYP24] induction . Regulation CYP24A1 VDR 9165006 432195 Pretreatment of mice with cycloheximide ( 400 microg/g ) , an inhibitor of protein synthesis , potentiated the increase in 24-OHase mRNA abundance , but blocked the increase in 24-OHase activity , induced by 1,25- ( OH ) 2D3 in kidney and duodenum , suggesting that [24-OHase] gene expression may be *regulated* not only by the but also by a short lived repressor protein . Regulation CYP26A1 NR2F1 23018522 2720234 Moreover , analysis of the expression of primary RA response genes indicates that is *involved* in the regulatory modulation of the expression of at least two genes , [CYP26A1] and HoxA1 . Regulation CYP26A1 RARB 16261163 1525713 Similarly , we found that [Cyp26a1] transcription is epigenetically *regulated* by . Regulation CYP2B6 IL1B 17576808 1778932 This article focuses on the *effects* of bacterial lipopolysaccaride (LPS) , interleukin-6 (IL-6) , tumor necrosis factor-alpha (TNF) , interferon gamma (IFN) , transforming growth factor-beta (TGF) and on expression of [CYP2B6] and the CYP2C mRNAs in human hepatocytes . Regulation CYP2B6 TNF 17576808 1778931 This article focuses on the *effects* of bacterial lipopolysaccaride (LPS) , interleukin-6 (IL-6) , , interferon gamma (IFN) , transforming growth factor-beta (TGF) and interleukin-1 beta (IL-1) on expression of [CYP2B6] and the CYP2C mRNAs in human hepatocytes . Regulation CYP2C19 IL1B 11001567 580805 [Cytochrome P450-2C11 (CYP 2C11)] is down-regulated in *response* to , and this response involves the hydrolysis of sphingomyelin to ceramide as well as ceramide to sphingosine , and phosphorylation of sphingosine to sphingosine 1-phosphate . Regulation CYP2C19 IL1B 17576808 1778937 This article focuses on the *effects* of bacterial lipopolysaccaride (LPS) , interleukin-6 (IL-6) , tumor necrosis factor-alpha (TNF) , interferon gamma (IFN) , transforming growth factor-beta (TGF) and on expression of CYP2B6 and the [CYP2C] mRNAs in human hepatocytes . Regulation CYP2C19 IL1B 9228043 443448 From these observations we conclude that sphingosine , possibly via sphingosine 1-phosphate , is a mediator of the *regulation* of [CYP2C11] by in rat hepatocytes and that ceramidase activation provides a `` switch '' that determines which sphingolipids are elevated by this cytokine to produce multiple intracellular responses . Regulation CYP2C19 TNF 15659313 1364901 These findings suggest that plays a key role in endotoxin induced down-regulation of hepatic P-glycoprotein , as well as *plays* a protective role in the regulation of hepatic CYP3A2 and [CYP2C11] against endotoxin induced acute inflammatory response . Regulation CYP2C19 TNF 17576808 1778936 This article focuses on the *effects* of bacterial lipopolysaccaride (LPS) , interleukin-6 (IL-6) , , interferon gamma (IFN) , transforming growth factor-beta (TGF) and interleukin-1 beta (IL-1) on expression of CYP2B6 and the [CYP2C] mRNAs in human hepatocytes . Regulation CYP2E1 FAS 15298768 1283566 We investigated the *effects* of different or with different degrees of unsaturation on [cytochrome P450 2E1 (CYP2E1)] induction and protein kinase C ( PKC ) activity in human hepatoma HepG2 cells . Regulation CYP3A TNF 15659313 1364902 These findings suggest that plays a key role in endotoxin induced down-regulation of hepatic P-glycoprotein , as well as *plays* a protective role in the regulation of hepatic [CYP3A2] and CYP2C11 against endotoxin induced acute inflammatory response . Regulation CYP3A TNF 21959890 2562403 Since TNF-a is one of the potent mediators that induce NOS2 and repress CYP3A transcription , the possible *involvement* of in this downregulation of [CYP3A] was discussed . Regulation CYP3A4 FAS 14615069 1163715 In the present study , we have investigated the *effects* of receptor activation on [CYP3A4] expression in human colon carcinoma HT-29 cells . Regulation CYP3A4 FAS 14615069 1163720 These results show that the receptor mediated signaling pathways *modulate* [CYP3A4] expression in human colon cancer cells . Regulation CYP4A11 IL1B 9354589 461641 *Regulation* of [CYP4A1] and peroxisome proliferator activated receptor alpha expression by , interleukin-6 , and dexamethasone in cultured fetal rat hepatocytes . Regulation CYP4A22 IL1B 9354589 461639 *Regulation* of [CYP4A1] and peroxisome proliferator activated receptor alpha expression by , interleukin-6 , and dexamethasone in cultured fetal rat hepatocytes . Regulation CYP7A1 FOXO1 16885156 1613823 Insulin regulation of [cholesterol 7alpha-hydroxylase] expression in human hepatocytes : *roles* of and sterol regulatory element binding protein 1c . Regulation CYP7A1 FOXO1 19463968 2128301 This study investigated the *roles* of in the regulation of [cholesterol 7alpha-hydroxylase] ( CYP7A1 ) gene expression in primary human hepatocytes . Regulation CYP7A1 IL1B 15476247 1319410 In addition , the regulatory *role* of on [CYP7B] activity in FLS was determined using RT-PCR , Western blotting , and high-performance liquid chromatography . Regulation CYP7A1 IL1B 16729332 1565765 Human primary hepatocytes and HepG2 cells were used as models to study chenodeoxycholic acid (CDCA) and *regulation* of human [CYP7A1] gene expression via real-time polymerase chain reaction , reporter assays , co-immunoprecipitation and chromatin immunocipitation ( ChIP ) assays . Regulation CYP7A1 IL1B 16729332 1565788 A JNK-specific inhibitor blocked the inhibitory *effect* of on HNF4 alpha expression and [CYP7A1] reporter activity . Regulation CYP7A1 TNF 11402042 842934 The negative *effects* of bile acids and on the transcription of [cholesterol 7alpha-hydroxylase] gene ( CYP7A1 ) converge to hepatic nuclear factor-4 : a novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors . Regulation CYP7A1 TNF 16049268 1447768 Herein , to clarify the *role* of in LN-induced downregulation of [cholesterol 7alpha-hydroxylase] , effects of LN on gene expression of hepatic cholesterol 7alpha-hydroxylase ( Cyp7a1 ) in TNF-alpha-knockout ( KO ) and TNF-alpha-wild-type ( WT ) mice were comparatively examined . Regulation CYP7A1 TNF 18511845 1945189 In this study , we investigated insulin , TGFbeta1 , and *regulation* of rat [Cyp7a1] gene transcription . Regulation CYR61 TNF 18202125 1895361 [CYR61] mRNA expression was further *regulated* by IL-1 , , PGE2 , and PGF2alpha . Regulation CYR61 TNF 18202125 1895364 The opposite *effect* of combined with hypoxia on [CYR61] up-regulation could contribute to a balanced expression level of this angiogenic factor in the endometrium . Regulation DAPK1 ATF6 22874566 2710062 IFNG stimulated proteolytic cleavage of , and MAPK1/3 ( ERK2/1 ) -dependent phosphorylation of CEBPB together *control* the expression of [Dapk1] . Regulation DAPK1 CALM3 12068633 955399 Hamster tumor cell lines obtained with the Rous sarcoma virus and characterized by a high metastatic activity in vitro were transfected with the gene for *dependent* serine-threonine [death associated protein kinase (DAPk)] . Regulation DAPK1 CALM3 24220854 2897374 Both [DAPK] and DRP-1 possess a conserved CaM autoregulatory domain , and are *regulated* by calcium activated and by an inhibitory auto-phosphorylation within the domain . Regulation DAPK1 CEBPB 22874566 2710036 Previously , we have shown that transcription factor ( C/EBP-ß ) *regulates* IFNG induced expression of [Dapk1] through a CRE/ATF motif in its enhancer . Regulation DAPK1 CEBPB 22874566 2710061 IFNG stimulated proteolytic cleavage of ATF6 , and MAPK1/3 ( ERK2/1 ) -dependent phosphorylation of together *control* the expression of [Dapk1] . Regulation DAPK1 GIF 22465880 2588966 In this present report , we attempted to characterize the *effects* of TNF-a and on [DAPk1] in human ovarian carcinoma cell lines , OVCAR-3 . Regulation DAPK1 MARK2 23948915 2850281 The phosphorylation level of microtubule affinity regulating kinase 2 ( MARK2 ) was increased by expression of [DAPK1] , but simultaneous downregulation of did not *affect* the DAPK1 induced tau hyperphosphorylation . Regulation DAPK1 PDLIM7 21353277 2411399 Data from LMP1 overexpression in LCLs and HeLa cells and from knocked down LMP1 in LCLs suggest *regulation* of [DAPK1] expression . Regulation DAPK1 PTPRF 17803936 1791092 The tumor suppressor [DAPK] is reciprocally *regulated* by tyrosine kinase Src and phosphatase . Regulation DAPK1 RASA1 21134130 2373003 Importantly , using a GTPase activating protein-dead missense mutation of TSC2 , we demonstrate that the effect of TSC2 on [DAPK] is *independent* of activity . Regulation DAPK1 SRC 17803936 1791091 The tumor suppressor [DAPK] is reciprocally *regulated* by tyrosine kinase and phosphatase LAR . Regulation DAPK1 TCF12 22874566 2710049 In this paper we have shown that ATF6 , an ER-resident *regulates* IFNG induced [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Regulation DAPK1 TCF15 22874566 2710050 In this paper we have shown that ATF6 , an ER-resident *regulates* IFNG induced [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Regulation DAPK1 TCF19 22874566 2710051 In this paper we have shown that ATF6 , an ER-resident *regulates* IFNG induced [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Regulation DAPK1 TCF20 22874566 2710052 In this paper we have shown that ATF6 , an ER-resident *regulates* IFNG induced [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Regulation DAPK1 TCF21 22874566 2710053 In this paper we have shown that ATF6 , an ER-resident *regulates* IFNG induced [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Regulation DAPK1 TCF23 22874566 2710057 In this paper we have shown that ATF6 , an ER-resident *regulates* IFNG induced [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Regulation DAPK1 TCF24 22874566 2710059 In this paper we have shown that ATF6 , an ER-resident *regulates* IFNG induced [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Regulation DAPK1 TCF25 22874566 2710058 In this paper we have shown that ATF6 , an ER-resident *regulates* IFNG induced [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Regulation DAPK1 TCF3 22874566 2710054 In this paper we have shown that ATF6 , an ER-resident *regulates* IFNG induced [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Regulation DAPK1 TCF4 22874566 2710055 In this paper we have shown that ATF6 , an ER-resident *regulates* IFNG induced [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Regulation DAPK1 TCF7 22874566 2710056 In this paper we have shown that ATF6 , an ER-resident *regulates* IFNG induced [Dapk1] expression through the CRE/ATF site , in association with CEBPB . Regulation DAPK1 TNF 17056602 1654574 In this study , we confirmed the existence of the alternatively spliced human DAPK-beta , and we examined the levels of DAPK autophosphorylation and [DAPK] catalytic activity in *response* to or ceramide . Regulation DAPK1 TNF 22465880 2588965 In this present report , we attempted to characterize the *effects* of and INF-? on [DAPk1] in human ovarian carcinoma cell lines , OVCAR-3 . Regulation DAPK1 TNFRSF1A 17324927 1747832 The transfection of the DAPK-1- ( 836-947 ) miniprotein acted in a dominant negative manner inducing endogenous [DAPK-1] protein degradation in a *dependent* manner . Regulation DAPK1 TP53 24811488 2944761 Both [DAPK1] and p14 ( ARF ) positively *regulate* whereas miR-34a and -34b/c are direct transcriptional targets of p53 . Regulation DAPK1 TSC2 21134130 2372997 *regulates* the stability of [death associated protein kinase-1 (DAPK)] through a lysosome dependent degradation pathway . Regulation DAPK1 TSC2 21134130 2372999 Furthermore , altering mTORC1 activity does not affect DAPK levels , excluding indirect *effects* of on [DAPK] protein levels through changes in mTORC1 translational control . Regulation DAPK1 TSC2 21134130 2373002 Importantly , using a GTPase activating protein-dead missense mutation of TSC2 , we demonstrate that the *effect* of on [DAPK] is independent of GTPase activating protein activity . Regulation DAPK2 TNF 17056602 1654575 In this study , we confirmed the existence of the alternatively spliced human DAPK-beta , and we examined the levels of DAPK autophosphorylation and [DAPK] catalytic activity in *response* to or ceramide . Regulation DAPK3 TNF 17056602 1654576 In this study , we confirmed the existence of the alternatively spliced human DAPK-beta , and we examined the levels of DAPK autophosphorylation and [DAPK] catalytic activity in *response* to or ceramide . Regulation DBH ARSA 9505234 477287 In this paper the *effect* of , D-xylo-AsA , L-arabo-AsA and D-arabo-AsA on the activity of [dopamine beta-hydroxylase] was studied to clarify whether or not the structural specificities of these stereoisomers have different effects on enzyme activity . Regulation DBH ARSA 9505234 477288 The *effect* of on the activity of [dopamine beta-hydroxylase] was almost the same as that of L-xylo-AsA , while D-xylo-AsA and L-arabo-AsA showed smaller effects . Regulation DBH FOXO1 25353004 2959874 *regulates* [Dbh] expression and the activity of the sympathetic nervous system in vivo . Regulation DCN CTGF 15313168 1285343 Differential *regulation* of biglycan and [decorin] synthesis by in cultured vascular endothelial cells . Regulation DCN IL1B 2211661 142709 When the *effect* of on the transcription of [decorin] was tested in these fibroblasts , the response was deficient as compared to control fibroblasts whereas transcription of type I and III collagen genes and versican was stimulated normally . Regulation DCN IL1B 9089489 421858 *Effects* of recombinant on [decorin] gene expression in human periodontal ligament fibroblast and its possible transcriptional regulation . Regulation DCN IL1B 9089489 421859 We investigated the *effect* of on [decorin] gene expression and its functional regulation to elucidate the intracellular mechanism mediating the action of IL-1 beta . Regulation DCN IL1B 9089489 421860 Most of the stimulation was blocked by Cx , indicating that the *regulation* of [decorin] gene expression by may be via an indirect pathway , requiring new protein synthesis which regulates the promoter . Regulation DCN IL1B 9689917 522949 In contrast , had a weak inhibitory *effect* on both [decorin] and biglycan expression . Regulation DCN TNF 8798756 381839 We have previously described a tumor necrosis factor alpha (TNF-alpha) response element , located between residues -188 and -140 of the human decorin promoter , that mediates the inhibitory *effect* of on [decorin] gene expression ( Mauviel , A. , Santra , M. , Chen , Y.-Q. , Uitto , J. , and Iozzo , R. V. ( 1995 ) J. Biol. Chem. 270 , 11692-11700 ) . Regulation DCN TNF 9485085 488228 These data demonstrate that 1 ) the expression of the core protein genes encoding the cartilage proteoglycans aggrecan , biglycan , and [decorin] is differentially *regulated* by IFN gamma and ; Regulation DCT MAP2K6 11310793 804833 Studies using inhibitors for protein kinases involved in cell signaling pathways suggested that stress activated kinase p38 and mitogen activated protein kinase kinase are *involved* in TPA independent regulation of [TYRP2] expression in melanocytes . Regulation DDAH1 TNF 10377069 623583 Accordingly , we studied the *effects* of oxidized LDL ( oxLDL ) or on the accumulation of ADMA by transformed human umbilical vein endothelial cells ( ECV304 ) and on the enzyme [dimethylarginine dimethylaminohydrolase] ( DDAH ) , which degrades ADMA . Regulation DDAH2 TNF 10377069 623585 Accordingly , we studied the *effects* of oxidized LDL ( oxLDL ) or on the accumulation of ADMA by transformed human umbilical vein endothelial cells ( ECV304 ) and on the enzyme [dimethylarginine dimethylaminohydrolase] ( DDAH ) , which degrades ADMA . Regulation DDIT3 EPHB2 9593703 505733 We observed similar , although less pronounced *effects* of SAPK2 and inhibition on hyperosmotic [GADD153] induction . Regulation DDR1 NES 23115280 2721463 The interaction between [NEP] and CRM1 is coordinately *regulated* by both the previously reported ( NES1 ) and now the new NES2 . Regulation DDX20 SMN2 10767334 684954 We suggest that the interaction between SMN and [DP103] is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Regulation DDX58 TNF 17182220 1688323 The present study was designed to investigate the *effects* of interferon (IFN)-gamma and on [RIG-I] expression in human keratinocytes , and the expression of RIG-I in skin lesions of psoriasis vulgaris , in which IFN-gamma and TNF-alpha are considered to be involved in its pathogenesis . Regulation DEFA1B TNF 20525314 2295373 In this study , we focused on noradrenergic and *regulation* of [human neutrophil peptides 1-3 (HNP1-3)] , which are proinflammatory bactericidal alpha-defensins . Regulation DEFB103B TLR7 18006661 1827306 Here , we show that [human beta-defensin-3 (hBD-3)] , an innate antimicrobial peptide , can induce expression of the costimulatory molecules CD80 , CD86 , and CD40 , on monocytes and myeloid dendritic cells in a *dependent* manner . Regulation DEFB4B TLR7 15494486 1321862 [Beta-defensin-2] expression is *regulated* by signaling in intestinal epithelial cells . Regulation DEFB4B TNF 22209221 2605446 The present results suggest that the pre-exposition to nicotine seems to reduce a stimulating *effect* of on the gene expression of [hBD-2] . Regulation DES CAPN8 17513494 1784009 We next determined that ventricular myocytes that underwent Ca ( 2+ ) overload also demonstrated a *dependent* disruption of [desmin] that could be reduced by H ( 2 ) O ( 2 ) /p38 MAPK activation . Regulation DES CAPN8 22161503 2579800 Therefore , our results suggest that BM <µ-calpain> with a faster and more extensive activation and autolysis would *play* a relatively dominant role in dictating degradation of [desmin] and troponin-T in postmortem duck muscle . Regulation DES RIC3 15932871 1433904 *Effects* of on [DEG-3/DES-2] functional expression are found in vivo and following heterologous expression in Xenopus leavis oocytes . Regulation DES RIC3 15932871 1433905 Indeed , *effects* of on functional expression of [DEG-3/DES-2] positively correlate with the DEG-3 to DES-2 ratio . Regulation DIABLO MAP2K6 17877640 1796723 In another clone ( PC70 ) , ICP10PK inhibited apoptosis through *dependent* up-regulation of the anti-apoptotic protein XIAP ( that inhibits the activity of processed caspase-3 ) and down-regulation of the apoptogenic protein [Smac/DIABLO] . Regulation DIANPH ANGPT1 24553436 2928915 We studied the mechanism of induced beneficial *effects* on [diabetic nephropathy] in db/db mice . Regulation DIANPH CTGF 15012739 1183025 The present study was designed to elucidate the *role* of in [diabetic nephropathy (DN)] , immunoglobulin A nephropathy (IgA-N) , membranous nephropathy ( MN ) , and minimal change nephrotic syndrome ( MCNS ) . Regulation DIANPH CTGF 16380465 1553974 Temporal expression profile and distribution pattern indicate a *role* of ( CTGF/CCN-2 ) in [diabetic nephropathy] in mice . Regulation DIANPH CTGF 18235518 1864366 Unraveling the *role* of in [diabetic nephropathy] . Regulation DIANPH CTGF 21978885 2546994 *plays* a pathogenic role in [diabetic nephropathy (DN)] . Regulation DIANPH CTGF 22053730 2567956 *plays* a pathogenic role in [diabetic nephropathy (DN)] . Regulation DIANPH SPON2 22235198 2519498 *Role* of in [diabetic nephropathy] . Regulation DIANPH TNF 17113815 1651167 The *role* of in [diabetic nephropathy] : pathogenic and therapeutic implications . Regulation DIANPH TNFAIP2 20665664 2335091 To the best of our knowledge , this is the first report which shows the *involvement* of PKC epsilon , DGK eta , , and Rho kinase in the liver of type 2 diabetic rats and its association with [diabetic nephropathy] . Regulation DIANPH TNFSF10 21251686 2452992 To investigate the *role* of in [diabetic nephropathy] , we measured the serum concentrations of OPG and TRAIL in type 2 diabetes mellitus patients with different stages of nephropathy by enzyme linked immunosorbent assay . Regulation DIO1 SYNM 19138393 2032130 Co administration of green tea and/or licorice with DMN attenuated the rising *effect* of on hepatic activity of Thyroxine [5--DI] while augmented the rising effect of DMN on plasma level of TSH . Regulation DIO1 TNF 7867596 296469 In the present study , we used FRTL5 cells , a cultured rat thyroid follicular cell line , to examine the *effects* of IFN-gamma and on [type I 5'-deiodinase] ( 5'D-I ) activity and 5'D-I , thyroid peroxidase (TPO) and thyroglobulin (Tg) gene expression . Regulation DIO1 TNF 7867596 296477 Northern blot analyses were performed to examine the *effect* of and IFN-gamma on [5'D-I] gene expression . Regulation DIO1 TNF 8180680 256325 did not significantly *affect* basal [5'D-I] but thyrotropin markedly increased 5'D-I ( p < 0.001 ) . Regulation DIO1 TNF 8180680 256330 Enzyme kinetic analysis demonstrated that thyrotropin increased 5'D-I by increasing Vmax ( p < 0.01 ) without significantly affecting Km. Likewise , TNF-alpha decreased the thyrotropin induced 5'D-I by decreasing Vmax ( p < 0.05 ) but not Km. The *effect* of on thyrotropin induced [5'D-I] in FRTL-5 cells is probably mediated through post-thyrotropin induced generation of cyclic adenosine monophosphate ( cAMP ) because TNF-alpha inhibited both dibutyryl cAMP ( p < 0.001 ) and forskolin ( p < 0.001 ) -induced increases in 5'D-I without affecting cAMP generation stimulated by thyrotropin . Regulation DISC1 EPHB2 20118622 2202416 The DISC formation , initial event of extrinsic apoptotic pathway , is a primary component of CSE- induced death in MRC-5 , and activation *plays* an active role in the [DISC] formation and downstream pathway . Regulation DISC1 FAS 18820240 2000778 However , the molecular mechanisms whereby Fas mutations and binding might *regulate* Fas mediated [DISC] formation are unknown . Regulation DISC1 FAS 24702583 2935335 The interaction between CaM and *regulates* Fas mediated [DISC] formation . Regulation DISC1 TNFSF10 19465019 2097336 Based on recent findings that the *dependent* [death inducing signaling complex (DISC)] forms and signals at the plasma membrane without being internalized , we investigated the possibility that agents that prevent endocytosis may stabilize the surface bound DISC and thereby enhance TRAIL dependent signaling . Regulation DISC2 EPHB2 20118622 2202417 The DISC formation , initial event of extrinsic apoptotic pathway , is a primary component of CSE- induced death in MRC-5 , and activation *plays* an active role in the [DISC] formation and downstream pathway . Regulation DISC2 FAS 18820240 2000780 However , the molecular mechanisms whereby Fas mutations and binding might *regulate* Fas mediated [DISC] formation are unknown . Regulation DISC2 FAS 24702583 2935337 The interaction between CaM and *regulates* Fas mediated [DISC] formation . Regulation DISC2 TNFSF10 19465019 2097337 Based on recent findings that the *dependent* [death inducing signaling complex (DISC)] forms and signals at the plasma membrane without being internalized , we investigated the possibility that agents that prevent endocytosis may stabilize the surface bound DISC and thereby enhance TRAIL dependent signaling . Regulation DKC1 IFI27 14612944 1163388 In this study , using the recombinant adenoviral vector expressing p27KIP1 ( Adp27KIP1 ) , we investigated whether *affects* [telomerase] activity in malignant glioma U373-MG cells . Regulation DKK1 CLU 23164821 2887157 To further elucidate how the *dependent* induction of [Dkk1] by Aß mediates neurotoxicity , we measured the effects of Aß and Dkk1 protein on whole-genome expression in primary neurons , finding a common pathway suggestive of activation of wnt-planar cell polarity (PCP)-c-Jun N-terminal kinase (JNK) signalling leading to the induction of genes including EGR1 ( early growth response-1 ) , NAB2 ( Ngfi-A binding protein-2 ) and KLF10 ( Krüppel-like factor-10 ) that , when individually silenced , protected against Aß neurotoxicity and/or tau phosphorylation . Regulation DKK1 KLF9 22259059 2564454 The aims were to investigate 1 ) KLF9 expression in eutopic endometrium of women with and without endometriosis , 2 ) *effects* of attenuated KLF9 expression on WNT signaling component expression and on WNT inhibitor [Dickkopf-1] promoter activity in human endometrial stromal cells ( HESC ) , and 3 ) PGR and coregulation of the stromal transcriptome network . Regulation DKK1 TNF 19183433 2079367 *regulation* of [Dickkopf-1] may constitute a molecular brake that controls osteoblastogenesis through wingless and bone morphogenetic proteins in an established inflammatory lesion in ankylosing spondylitis . Regulation DLD COL17A1 12786825 1096732 This reflects the pivotal *role* of in [LAD] . Regulation DLG4 CAPN8 18445709 1938619 These data suggest that activation suppresses NMDAR function via proteolytic cleavage of NR2 subunits in vitro and in vivo , and the susceptibility of NMDARs to calpain cleavage is *controlled* by [PSD-95] and calcineurin . Regulation DLX3 TP63 17164413 1679047 Homeobox gene [Dlx3] is *regulated* by during ectoderm development : relevance in the pathogenesis of ectodermal dysplasias . Regulation DMD TNF 20373002 2282038 Further , we examined the *effect* of on myocardial expression of titin and [dystrophin] in vitro in rat cardiac myoblast cell line ( H9c2 ) . Regulation DNAJC5 GPR132 10992502 732925 Intradermal injection of the CSP genetic vaccine induced a strong Th1-type immune response characterized by a dominant [CSP-specific] immunoglobulin ( IgG2a ) humoral *response* and high levels of gamma interferon produced by splenic T cells . Regulation DNASE1 RNASE1 8594414 335358 The effect of L-RNA was dependent of the integrity of the polynucleotide chain and was not due to LPS contamination since its ability to induce MNCF and IL-8 release was strongly reduced by but was not *affected* by [DNase] or polymyxin B . Regulation DNASE1 RNASE7 8594414 335366 The effect of L-RNA was dependent of the integrity of the polynucleotide chain and was not due to LPS contamination since its ability to induce MNCF and IL-8 release was strongly reduced by but was not *affected* by [DNase] or polymyxin B . Regulation DNASE2 RNASE1 8594414 335370 The effect of L-RNA was dependent of the integrity of the polynucleotide chain and was not due to LPS contamination since its ability to induce MNCF and IL-8 release was strongly reduced by but was not *affected* by [DNase] or polymyxin B . Regulation DNASE2 RNASE7 8594414 335378 The effect of L-RNA was dependent of the integrity of the polynucleotide chain and was not due to LPS contamination since its ability to induce MNCF and IL-8 release was strongly reduced by but was not *affected* by [DNase] or polymyxin B . Regulation DNLZ PLAU 21465475 2523646 The *effect* of on [SK-Hep-1] signaling and SDF-1 expression is mediated by uPAR . Regulation DNMT1 EPHB2 12632429 1068220 Hydralazine reproduces the lupus pathway signaling abnormality and its *effects* on [DNMT] expression , and inhibiting this pathway induces autoimmunity . Regulation DNMT1 EPHB2 23576011 2804320 DNA methylation depends on both dietary transmethylation micronutrients and *regulated* [DNA methyltransferase 1 (DNMT-1)] levels . Regulation DOCK2 PTGER2 23318649 2752916 [Dedicator of cytokinesis 2 (DOCK2)] is a guanyl nucleotide exchange factor expressed exclusively in microglia in the brain and is *regulated* by PGE2 receptor . Regulation DOK1 ANGPT1 12665569 1074878 Introduction of a Tie2 mutant lacking tyrosine residue 1106 into endothelial cells interferes with [Dok-R] phosphorylation in *response* to . Regulation DOK2 ANGPT1 12665569 1074879 Introduction of a Tie2 mutant lacking tyrosine residue 1106 into endothelial cells interferes with [Dok-R] phosphorylation in *response* to . Regulation DOK3 ANGPT1 12665569 1074875 Introduction of a Tie2 mutant lacking tyrosine residue 1106 into endothelial cells interferes with [Dok-R] phosphorylation in *response* to . Regulation DOK4 ANGPT1 12665569 1074874 Introduction of a Tie2 mutant lacking tyrosine residue 1106 into endothelial cells interferes with [Dok-R] phosphorylation in *response* to . Regulation DOK5 ANGPT1 12665569 1074873 Introduction of a Tie2 mutant lacking tyrosine residue 1106 into endothelial cells interferes with [Dok-R] phosphorylation in *response* to . Regulation DOK6 ANGPT1 12665569 1074877 Introduction of a Tie2 mutant lacking tyrosine residue 1106 into endothelial cells interferes with [Dok-R] phosphorylation in *response* to . Regulation DOK7 ANGPT1 12665569 1074876 Introduction of a Tie2 mutant lacking tyrosine residue 1106 into endothelial cells interferes with [Dok-R] phosphorylation in *response* to . Regulation DONSON FOXA1 20736324 2345816 We recently reported that *regulates* the basal expression of the [UGT2B17] gene in prostate cancer cells . Regulation DONSON FOXA1 20736324 2345823 Because local inactivation of active androgens by UGT2B15 and UGT2B17 has been shown to be a major determinant of androgen response and signaling activity , *regulation* of the UGT2B15 and [UGT2B17] genes by may have an important role in the maintenance of androgen homeostasis within prostate cancer cells . Regulation DPP4 IL1B 17708459 1783104 On the other hand , TNFalpha , , and IFN-gamma did not *affect* [DPP-IV] activity but significantly increased the cellular expression and the basolateral secretion of BDNF . Regulation DPP4 TNF 10880264 709122 The fact that translation and probably translocation of [CD26] toward the cell surface can be *regulated* by IL-12 and reveals new aspects about the control of this T(H1)marker . Regulation DPP4 TNF 17708459 1783102 On the other hand , , IL-1beta , and IFN-gamma did not *affect* [DPP-IV] activity but significantly increased the cellular expression and the basolateral secretion of BDNF . Regulation DPYSL3 CAPN8 16987501 1640575 Recently , we have shown that in primary cortical neurons (PCN) NMDA and oxidative stress ( H ( 2 ) O ( 2 ) ) caused a *dependent* cleavage of [DPYSL3] ( 62 kDa ) resulting in the appearance of a lower molecular weight form ( 60 kDa ) of DPYSL3 . Regulation DPYSL3 CAPN8 18053648 1852529 Recently we have shown that glutamate excitotoxicity and oxidative stress result in *dependent* cleavage of [DPYSL3] , and that NOS plays a role in this process [ R. Kowara , Q. Chen , M. Milliken , B. Chakravarthy , Calpain mediated truncation of dihydropyrimidinase-like 3 protein ( DPYSL3 ) in response to NMDA and H2O2 toxicity , J. Neurochem. 95 ( 2005 ) 466-474 ; Regulation DRG1 TNF 11849773 912923 To further understand the *role* of in [DRG] , we injected rat L5 DRG with biotinylated TNF alpha , neurobiotin , or vehicle , and detected translocation of the biotin tag by avidin-biotin histochemistry . Regulation DRG2 EPHB2 23360825 2758723 Inhibition of these proteins abolished the effects of DRG2 on formation of large OCs with actin rings , implying that [DRG2] affects cytoskeleton reorganization in a *dependent* manner . Regulation DRG2 TNF 11849773 912924 To further understand the *role* of in [DRG] , we injected rat L5 DRG with biotinylated TNF alpha , neurobiotin , or vehicle , and detected translocation of the biotin tag by avidin-biotin histochemistry . Regulation DST MAOA 8488751 219220 The clinical efficacy of the inhibitor moclobemide and its *effect* on the [dexamethasone suppression test (DST)] and plasma and urine methoxyhydroxyphenylglycol ( MHPG ) were investigated in 26 depressed patients during a 4-week clinical trial . Regulation DUSP1 EPHB2 11104676 756450 Compartment-specific regulation of extracellular signal regulated kinase ( ERK ) and c-Jun N-terminal kinase (JNK) mitogen activated protein kinases ( MAPKs ) by ERK dependent and *dependent* inductions of MAPK phosphatase (MKP)-3 and [MKP-1] in differentiating P19 cells . Regulation DUSP1 EPHB2 12948857 1137043 Increased [MKP-1] expression was *dependent* on the mitogen activated protein kinase , . Regulation DUSP1 EPHB2 18786515 2008949 The increase of [Dusp1] and Dusp5 mRNAs is not *controlled* by activation while that of Dusp14 is a direct negative-feedback mechanism of MDMA induced ERK signalling . Regulation DUSP1 EPHB2 23076500 2740558 These results suggest that Gln suppresses DNFB induced CD via deactivation of p38 MAPK through the early induction of [MKP-1] , the negative regulator of p38 , in an *dependent* manner . Regulation DUSP1 EPHB2 24253595 2910483 We examined the *role* of in the regulation of [MKP1] and JNK , and p38 activities and apoptosis . Regulation DUSP1 EPHB2 24253595 2910510 Thus , activity *controls* the levels of [MKP-1] and , thereby , regulates JNK activity in polyamine depleted cells . Regulation DUSP1 EPHB2 9148952 430044 In this way , signals may *regulate* [MKP-1] expression , the magnitude of sustained ERK1 activity , and therefore gene expression . Regulation DUSP1 MAP2K6 24253595 2910489 We examined the *role* of in the regulation of [MKP1] and JNK , and p38 activities and apoptosis . Regulation DUSP1 MAP2K6 24253595 2910516 Thus , activity *controls* the levels of [MKP-1] and , thereby , regulates JNK activity in polyamine depleted cells . Regulation DUSP1 TNF 9278272 450844 We examined the *effects* of IR and on [HVH1] and IkappaB alpha gene expression . Regulation DUSP26 EPHB2 16581800 1543958 While activated ERK phosphorylates Hsf4b , [DUSP26] *controls* the activity of , leading to phosphorylation/dephosphorylation of Hsf4b , altering its ability to bind DNA . Regulation DUSP4 MAP2K6 11162624 782303 Pancreatic tumor cells with mutant K-ras suppress ERK activity by *dependent* induction of [MAP kinase phosphatase-2] . Regulation DUSP5 EPHB2 18786515 2008950 The increase of Dusp1 and [Dusp5] mRNAs is not *controlled* by activation while that of Dusp14 is a direct negative-feedback mechanism of MDMA induced ERK signalling . Regulation DUSP5 EPHB2 19666109 2143890 *Regulation* of the inducible nuclear dual-specificity phosphatase [DUSP5] by MAPK . Regulation DUSP5 EPHB2 20806045 2313863 [DUSP5] and DUSP6 selectively *control* pathway activity and proliferation . Regulation DUSP5 EPHB2 21828247 2495570 Hippocampal dual specificity phosphatase 5 (DUSP5) may be involved in these morbidities because [DUSP5] *regulates* extracellular signal regulated kinase phosphorylation ( ) . Regulation DUSP5 EPHB2 23720316 2796832 Signal dependent repression of [DUSP5] by class I HDACs *controls* nuclear activity and cardiomyocyte hypertrophy . Regulation DUSP6 EPHB2 10811804 714656 Consistent with this , we show that peptides representing docking sites within the target substrates Elk-1 and p90 ( rsk ) inhibit *dependent* activation of [MKP-3] . Regulation DUSP6 EPHB2 11104676 756451 Compartment-specific regulation of extracellular signal regulated kinase ( ERK ) and c-Jun N-terminal kinase (JNK) mitogen activated protein kinases ( MAPKs ) by *dependent* and non-ERK dependent inductions of [MAPK phosphatase (MKP)-3] and MKP-1 in differentiating P19 cells . Regulation DUSP6 EPHB2 20097731 2226254 Our results indicate that [DUSP6] expression is *regulated* by signaling and that DUSP6 exerts antitumor effects via negative feedback regulation , pointing to an important feedback loop in NSCLC . Regulation DUSP6 EPHB2 20806045 2313864 DUSP5 and [DUSP6] selectively *control* pathway activity and proliferation . Regulation DUT CAPN8 21625588 2436925 Results argue for a mechanism where Ca ( 2+ ) <-calpain> may *regulate* nuclear availability and degradation of [dUTPase] . Regulation DUT NES 20461535 2283150 We have discovered for the first time that the *dependent* translocation of [dUTPase] is different for SGIV than for members of other species , which depend on a nuclear localization signal . Regulation DVL1 SYT8 17212654 1681711 [Dvl] *regulates* endo- and exocytotic processes through binding to . Regulation DVL2 SYT8 17212654 1681728 [Dvl] *regulates* endo- and exocytotic processes through binding to . Regulation DVL3 SYT8 17212654 1681745 [Dvl] *regulates* endo- and exocytotic processes through binding to . Regulation DYSF TNF 18276788 1872079 siRNA mediated inhibition of [dysferlin] expression in the J774 macrophage cell line resulted in significantly enhanced phagocytosis , both at baseline and in *response* to . Regulation E2F1 ADRB2 18519784 1918647 In addition , levels of E2F1 were up-regulated by Ad-RB94/XRT combination , whereas alone did not *affect* [E2F1] levels and XRT alone led to down-regulation of E2F1 . Regulation E2F1 CCND1 7970707 280136 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Regulation E2F1 CCND1 9001421 410316 These studies show that Rb interaction with [E2F1] is *regulated* by cdk4 and within p210 BCR-ABL transformed leukemia cells in early G1 phase of the cell cycle . Regulation E2F1 IFI27 11577016 865199 Although expression of E2F-1 was reduced in three prostate cancer cell lines-PC-3 , LNCaP and DU-145-the p21 and p27 protein levels were not increased in all the cell lines treated , suggesting that increase in p21 and protein expression per se is not *responsible* for lovastatin mediated down-regulation of [E2F-1] . Regulation E2F1 IFI27 9668055 519176 The inhibitory *effect* of the cyclin dependent kinase inhibitors , p16(ink4) , p21 ( cip1 ) , and ( cip ) on Rac/Cdc42 mediated [E2F] transcription corroborates a role for pRB family members and their functional inactivation by cyclin dependent kinases in generating E2F activity . Regulation E2F1 TNF 14576193 1158755 Taken together , these data suggest a differential requirement of JNK1 and p38 MAPK in *regulation* of [E2F1] . Regulation E2F2 CCND1 7970707 280137 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Regulation E2F2 IFI27 9668055 519198 The inhibitory *effect* of the cyclin dependent kinase inhibitors , p16(ink4) , p21 ( cip1 ) , and ( cip ) on Rac/Cdc42 mediated [E2F] transcription corroborates a role for pRB family members and their functional inactivation by cyclin dependent kinases in generating E2F activity . Regulation E2F3 CCND1 7970707 280138 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Regulation E2F3 IFI27 9668055 519220 The inhibitory *effect* of the cyclin dependent kinase inhibitors , p16(ink4) , p21 ( cip1 ) , and ( cip ) on Rac/Cdc42 mediated [E2F] transcription corroborates a role for pRB family members and their functional inactivation by cyclin dependent kinases in generating E2F activity . Regulation E2F4 CCND1 18478976 1910559 however , in HELFs treated with 100 micromol/L B [ a ] P , both and CDK4 negatively *regulate* the [E2F-4] expression . Regulation E2F4 CCND1 7970707 280139 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Regulation E2F4 EPHB2 22214150 2519153 It was found that and JNK were *involved* in silica induced cyclin D1 and CDK4 overexpression and the decreased expression of [E2F-4] . Regulation E2F4 IFI27 9668055 519242 The inhibitory *effect* of the cyclin dependent kinase inhibitors , p16(ink4) , p21 ( cip1 ) , and ( cip ) on Rac/Cdc42 mediated [E2F] transcription corroborates a role for pRB family members and their functional inactivation by cyclin dependent kinases in generating E2F activity . Regulation E2F5 CCND1 7970707 280140 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Regulation E2F5 IFI27 9668055 519264 The inhibitory *effect* of the cyclin dependent kinase inhibitors , p16(ink4) , p21 ( cip1 ) , and ( cip ) on Rac/Cdc42 mediated [E2F] transcription corroborates a role for pRB family members and their functional inactivation by cyclin dependent kinases in generating E2F activity . Regulation E2F6 CCND1 7970707 280141 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Regulation E2F6 IFI27 9668055 519286 The inhibitory *effect* of the cyclin dependent kinase inhibitors , p16(ink4) , p21 ( cip1 ) , and ( cip ) on Rac/Cdc42 mediated [E2F] transcription corroborates a role for pRB family members and their functional inactivation by cyclin dependent kinases in generating E2F activity . Regulation E2F7 CCND1 7970707 280134 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Regulation E2F7 IFI27 9668055 519132 The inhibitory *effect* of the cyclin dependent kinase inhibitors , p16(ink4) , p21 ( cip1 ) , and ( cip ) on Rac/Cdc42 mediated [E2F] transcription corroborates a role for pRB family members and their functional inactivation by cyclin dependent kinases in generating E2F activity . Regulation E2F8 CCND1 7970707 280135 The data reported here support a direct *role* for and its associated kinase in cell cycle regulation of [E2F] activity and S phase-specific gene expression . Regulation E2F8 IFI27 9668055 519154 The inhibitory *effect* of the cyclin dependent kinase inhibitors , p16(ink4) , p21 ( cip1 ) , and ( cip ) on Rac/Cdc42 mediated [E2F] transcription corroborates a role for pRB family members and their functional inactivation by cyclin dependent kinases in generating E2F activity . Regulation EBI3 TLR7 15728491 1377271 In summary , these data suggest that [EBI3] expression in DCs is transcriptionally *regulated* by signaling via MyD88 and NF-kappaB . Regulation ECE1 MMP28 12477147 1023820 While neutral endopeptidase (NEP) and matrix metalloproteinase-2 (MMP-2) are able to process big ET-1 , inhibitors of NEP ( thiorphan ) and ( batimistat ) did not *affect* [ECE-1] activity . Regulation ECE1 MMP7 12477147 1023836 While neutral endopeptidase (NEP) and matrix metalloproteinase-2 (MMP-2) are able to process big ET-1 , inhibitors of NEP ( thiorphan ) and ( batimistat ) did not *affect* [ECE-1] activity . Regulation ECM1 CD14 19710907 2127343 We find that *plays* a predominant role in the induction of [ECM] and regulation of parasite density ; Regulation ECM1 CTGF 12217862 986373 To clarify the common and divergent roles of these growth factors in the cells responsible for pathological extracellular matrix (ECM) deposition in renal fibrosis , the *effects* of TGF-beta and on [ECM] expression in primary human mesangial ( HMCs ) and human proximal tubule epithelial cells ( HTECs ) were studied . Regulation ECM1 CTGF 15579446 1344863 To determine the critical *role* of in AGE induced [ECM] accumulation leading to diabetic nephropathy , rats were given AGEs by intravenous injection for 6 weeks . Regulation ECM1 CTGF 15579446 1344868 These results suggest that AGE induced expression , predominantly through a TGF-beta 1-independent pathway , *plays* a critical role in renal [ECM] accumulation leading to diabetic nephropathy . Regulation ECM1 CTGF 15976312 1434719 In vascular smooth muscle cells ( VSMCs ) , *regulates* cell proliferation/apoptosis , migration , and [extracellular matrix (ECM)] accumulation . Regulation ECM1 CTGF 17393107 1716263 In order to investigate the effects of connective tissue growth factor (CTGF) antisense oligodeoxynucleotide ( ODN ) on plasminogen activator inhibitor-1 ( PAI-1 ) expression in renal tubular cells induced by transforming growth factor beta1 ( TGF-beta1 ) and to explore the *role* of in the degradation of renal [extracellular matrix (ECM)] , a human proximal tubular epithelial cell line ( HKC ) was cultured in vitro . Regulation ECM1 CTGF 17393107 1716270 It was concluded that might *play* a crucial role in the degradation of excessive [ECM] during tubulointerstitial fibrosis , and blocking the biological effect of CTGF may be a novel way in preventing renal fibrosis . Regulation ECM1 CTGF 18369694 1888217 These findings indicate that is *involved* in [ECM] production in SCFs activated by exogenous TGFbeta1 in vitro . Regulation ECM1 CTGF 19111553 2031726 In different cell types *regulates* cell proliferation/apoptosis , migration , and [extracellular matrix (ECM)] accumulation and plays important roles in angiogenesis , chondrogenesis , osteogenesis , tissue repair , cancer and fibrosis . Regulation ECM1 CTGF 21330667 2431526 The purposes of this study were to quantify aqueous humor connective tissue growth factor (CTGF) in PXF glaucoma , to determine the *effect* of on [ECM] production in TM cells , and to identify intracellular CTGF signaling pathways . Regulation ECM1 CTGF 21645240 2579211 ( CTGF/CCN-2 ) is mainly *involved* in the induction of [extracellular matrix (ECM)] proteins . Regulation ECM1 CTGF 23946690 2827199 Therefore , the goal of this study is to identify the signaling pathways of *effects* on [ECM] accumulation and cell proliferation in VSMCs under hyperglycemia . Regulation ECM1 CTGF 24302644 2899134 was among a small group of genes regulated by the amount of cyclic shortening regardless of the level of mean stretch , and many more [ECM] genes were *regulated* by shortening with reduced amounts of stretch . Regulation ECM1 CTGF 24392320 2883985 To investigate the *effects* of transforming growth factor ß2 ( TGF-ß2 ) and on transdifferentiation of human lens epithelial cells ( HLECs ) cultured in vitro and synthesis of [extracellular matrix (ECM)] . Regulation ECM1 EPHB2 22483454 2579026 These results suggested that NADPH oxidase mediated ROS and subsequent and p38 MAPK activation *play* important roles in [ECM] accumulation in the renal tubulointerstitium . Regulation ECM1 HBEGF 23305395 2738067 We evaluated the *effect* of on the expression of integrins , E-cadherin/ß-catenin , and integrin a5ß1 dependent [cell-ECM] interactions . Regulation ECM1 IL1B 10868970 706654 Glomerular mRNA synthesis was also enhanced as early as day 1 and could be *involved* in the increase in [ECM] and adhesion molecule gene expressions . Regulation ECM1 MMP28 10849774 701350 are *involved* in degradation of the [extracellular matrix (ECM)] . Regulation ECM1 MMP28 16891619 1607706 It has been assumed that diminished activity is *responsible* for the accumulation of the [extracellular matrix (ECM)] proteins and collagens that typify the fibrotic kidney . Regulation ECM1 MMP28 17919732 1825155 *play* critical roles in ECM remodeling and/or regulation of [cell-ECM] interactions because of their ability to cleave protein components of the ECM . Regulation ECM1 MMP28 19664242 2125884 As *play* a central role in the regulation of the [ECM] , an increased expression of these enzymes might lead to the endothelial damage in spontaneous cervical artery dissection ( sCAD ) . Regulation ECM1 MMP28 21920495 2567738 We provide evidence that HSC-3 OSCC has a tendency to adopt invadopodia for invasion and accompanying *dependent* proteolytic [ECM] degradation and EGFR signalling is necessary for invadopodia formation and associated ECM degradation activity . Regulation ECM1 MMP7 10849774 701365 are *involved* in degradation of the [extracellular matrix (ECM)] . Regulation ECM1 MMP7 16891619 1607721 It has been assumed that diminished activity is *responsible* for the accumulation of the [extracellular matrix (ECM)] proteins and collagens that typify the fibrotic kidney . Regulation ECM1 MMP7 17919732 1825170 *play* critical roles in ECM remodeling and/or regulation of [cell-ECM] interactions because of their ability to cleave protein components of the ECM . Regulation ECM1 MMP7 19664242 2125899 As *play* a central role in the regulation of the [ECM] , an increased expression of these enzymes might lead to the endothelial damage in spontaneous cervical artery dissection ( sCAD ) . Regulation ECM1 MMP7 21920495 2567753 We provide evidence that HSC-3 OSCC has a tendency to adopt invadopodia for invasion and accompanying *dependent* proteolytic [ECM] degradation and EGFR signalling is necessary for invadopodia formation and associated ECM degradation activity . Regulation ECM1 PLAT 16038272 1437345 To study the *role* of plasminogen activator inhibitor-1 ( PAI-1 ) and in the accumulation of [extracellular matrix (ECM)] in the kidney of KKAy mice with type 2 diabetes . Regulation ECM1 PLAU 12784997 1096667 Secondly , *regulates* [cell/ECM] interactions as an adhesion receptor for vitronectin (Vn) and through its capacity to modulate integrin function . Regulation ECM1 PLAU 15257104 1272335 Tumor associated trypsinogen (TAT) , ( u-PA ) , matrix metalloproteinase-2 (MMP-2) , and MMP-9 each play a dominant *role* in the degradation of [extracellular matrix (ECM)] during the invasion process of pancreatic cancer . Regulation ECM1 PLAU 17625304 1770145 Tumor associated trypsinogen , , matrix metalloprotease-2 (MMP-2) , and MMP-9 each play a dominant *role* in the degradation of the [extracellular matrix (ECM)] during the invasion process of pancreatic cancer . Regulation ECM1 PLAU 18481824 1939067 Liver fibrosis results from chronic liver damage characterized by an accumulation of extracellular matrix (ECM) and levels of ( uPA ) *play* an important role in [ECM] degradation . Regulation ECM1 PLAU 19181000 2007125 Herein we have focused on the *role* of ( uPA ) and transforming growth factor beta 1 ( TGF/1 ) in [ECM] degradation and reconstitution in muscles . Regulation ECM1 PLAU 8356923 227522 The upregulation of results in an alteration in the fibrinolytic capacity of endothelial cells and allows cells the selective ability to degrade and invade *underlying* subendothelial [extracellular matrix (ECM)] . Regulation ECM1 TGM2 16936095 1608920 In the present study , the *role* of in the accumulation of [extracellular matrix (ECM)] proteins in these scars was investigated . Regulation ECM1 TNF 18439917 1920990 The [extracellular matrix (ECM)] of the vasculature is a major target of inflammatory cytokines , and *regulates* ECM metabolism by affecting collagen production . Regulation ECM2 CD14 19710907 2127344 We find that *plays* a predominant role in the induction of [ECM] and regulation of parasite density ; Regulation ECM2 CTGF 12217862 986374 To clarify the common and divergent roles of these growth factors in the cells responsible for pathological extracellular matrix (ECM) deposition in renal fibrosis , the *effects* of TGF-beta and on [ECM] expression in primary human mesangial ( HMCs ) and human proximal tubule epithelial cells ( HTECs ) were studied . Regulation ECM2 CTGF 15579446 1344864 To determine the critical *role* of in AGE induced [ECM] accumulation leading to diabetic nephropathy , rats were given AGEs by intravenous injection for 6 weeks . Regulation ECM2 CTGF 15579446 1344870 These results suggest that AGE induced expression , predominantly through a TGF-beta 1-independent pathway , *plays* a critical role in renal [ECM] accumulation leading to diabetic nephropathy . Regulation ECM2 CTGF 15976312 1434720 In vascular smooth muscle cells ( VSMCs ) , *regulates* cell proliferation/apoptosis , migration , and [extracellular matrix (ECM)] accumulation . Regulation ECM2 CTGF 17393107 1716264 In order to investigate the effects of connective tissue growth factor (CTGF) antisense oligodeoxynucleotide ( ODN ) on plasminogen activator inhibitor-1 ( PAI-1 ) expression in renal tubular cells induced by transforming growth factor beta1 ( TGF-beta1 ) and to explore the *role* of in the degradation of renal [extracellular matrix (ECM)] , a human proximal tubular epithelial cell line ( HKC ) was cultured in vitro . Regulation ECM2 CTGF 17393107 1716271 It was concluded that might *play* a crucial role in the degradation of excessive [ECM] during tubulointerstitial fibrosis , and blocking the biological effect of CTGF may be a novel way in preventing renal fibrosis . Regulation ECM2 CTGF 18369694 1888218 These findings indicate that is *involved* in [ECM] production in SCFs activated by exogenous TGFbeta1 in vitro . Regulation ECM2 CTGF 19111553 2031727 In different cell types *regulates* cell proliferation/apoptosis , migration , and [extracellular matrix (ECM)] accumulation and plays important roles in angiogenesis , chondrogenesis , osteogenesis , tissue repair , cancer and fibrosis . Regulation ECM2 CTGF 21330667 2431527 The purposes of this study were to quantify aqueous humor connective tissue growth factor (CTGF) in PXF glaucoma , to determine the *effect* of on [ECM] production in TM cells , and to identify intracellular CTGF signaling pathways . Regulation ECM2 CTGF 21645240 2579212 Connective tissue growth factor ( ) is mainly *involved* in the induction of [extracellular matrix (ECM)] proteins . Regulation ECM2 CTGF 23946690 2827200 Therefore , the goal of this study is to identify the signaling pathways of *effects* on [ECM] accumulation and cell proliferation in VSMCs under hyperglycemia . Regulation ECM2 CTGF 24302644 2899135 was among a small group of genes regulated by the amount of cyclic shortening regardless of the level of mean stretch , and many more [ECM] genes were *regulated* by shortening with reduced amounts of stretch . Regulation ECM2 CTGF 24392320 2883986 To investigate the *effects* of transforming growth factor ß2 ( TGF-ß2 ) and on transdifferentiation of human lens epithelial cells ( HLECs ) cultured in vitro and synthesis of [extracellular matrix (ECM)] . Regulation ECM2 EPHB2 22483454 2579040 These results suggested that NADPH oxidase mediated ROS and subsequent and p38 MAPK activation *play* important roles in [ECM] accumulation in the renal tubulointerstitium . Regulation ECM2 HBEGF 23305395 2738068 We evaluated the *effect* of on the expression of integrins , E-cadherin/ß-catenin , and integrin a5ß1 dependent [cell-ECM] interactions . Regulation ECM2 IL1B 10868970 706655 Glomerular mRNA synthesis was also enhanced as early as day 1 and could be *involved* in the increase in [ECM] and adhesion molecule gene expressions . Regulation ECM2 MMP28 10849774 701372 are *involved* in degradation of the [extracellular matrix (ECM)] . Regulation ECM2 MMP28 16891619 1607728 It has been assumed that diminished activity is *responsible* for the accumulation of the [extracellular matrix (ECM)] proteins and collagens that typify the fibrotic kidney . Regulation ECM2 MMP28 17919732 1825177 *play* critical roles in ECM remodeling and/or regulation of [cell-ECM] interactions because of their ability to cleave protein components of the ECM . Regulation ECM2 MMP28 19664242 2125906 As *play* a central role in the regulation of the [ECM] , an increased expression of these enzymes might lead to the endothelial damage in spontaneous cervical artery dissection ( sCAD ) . Regulation ECM2 MMP28 21920495 2567760 We provide evidence that HSC-3 OSCC has a tendency to adopt invadopodia for invasion and accompanying *dependent* proteolytic [ECM] degradation and EGFR signalling is necessary for invadopodia formation and associated ECM degradation activity . Regulation ECM2 MMP7 10849774 701387 are *involved* in degradation of the [extracellular matrix (ECM)] . Regulation ECM2 MMP7 16891619 1607743 It has been assumed that diminished activity is *responsible* for the accumulation of the [extracellular matrix (ECM)] proteins and collagens that typify the fibrotic kidney . Regulation ECM2 MMP7 17919732 1825192 *play* critical roles in ECM remodeling and/or regulation of [cell-ECM] interactions because of their ability to cleave protein components of the ECM . Regulation ECM2 MMP7 19664242 2125921 As *play* a central role in the regulation of the [ECM] , an increased expression of these enzymes might lead to the endothelial damage in spontaneous cervical artery dissection ( sCAD ) . Regulation ECM2 MMP7 21920495 2567775 We provide evidence that HSC-3 OSCC has a tendency to adopt invadopodia for invasion and accompanying *dependent* proteolytic [ECM] degradation and EGFR signalling is necessary for invadopodia formation and associated ECM degradation activity . Regulation ECM2 PLAT 16038272 1437347 To study the *role* of plasminogen activator inhibitor-1 ( PAI-1 ) and in the accumulation of [extracellular matrix (ECM)] in the kidney of KKAy mice with type 2 diabetes . Regulation ECM2 PLAU 12784997 1096669 Secondly , *regulates* [cell/ECM] interactions as an adhesion receptor for vitronectin (Vn) and through its capacity to modulate integrin function . Regulation ECM2 PLAU 15257104 1272338 Tumor associated trypsinogen (TAT) , ( u-PA ) , matrix metalloproteinase-2 (MMP-2) , and MMP-9 each play a dominant *role* in the degradation of [extracellular matrix (ECM)] during the invasion process of pancreatic cancer . Regulation ECM2 PLAU 17625304 1770148 Tumor associated trypsinogen , , matrix metalloprotease-2 (MMP-2) , and MMP-9 each play a dominant *role* in the degradation of the [extracellular matrix (ECM)] during the invasion process of pancreatic cancer . Regulation ECM2 PLAU 18481824 1939068 Liver fibrosis results from chronic liver damage characterized by an accumulation of extracellular matrix (ECM) and levels of ( uPA ) *play* an important role in [ECM] degradation . Regulation ECM2 PLAU 19181000 2007127 Herein we have focused on the *role* of ( uPA ) and transforming growth factor beta 1 ( TGF/1 ) in [ECM] degradation and reconstitution in muscles . Regulation ECM2 PLAU 8356923 227523 The upregulation of results in an alteration in the fibrinolytic capacity of endothelial cells and allows cells the selective ability to degrade and invade *underlying* subendothelial [extracellular matrix (ECM)] . Regulation ECM2 TGM2 16936095 1608921 In the present study , the *role* of in the accumulation of [extracellular matrix (ECM)] proteins in these scars was investigated . Regulation ECM2 TNF 18439917 1920991 The [extracellular matrix (ECM)] of the vasculature is a major target of inflammatory cytokines , and *regulates* ECM metabolism by affecting collagen production . Regulation EDN1 ANGPT1 16741035 1566598 *Regulation* of [endothelin-1] by : implications for inflammation . Regulation EDN1 CTGF 19111553 2031732 Moreover , in cells treated with ET-1 the expression of ECM component decorin was abolished by CTGF silencing , indicating that is *involved* in [ET-1] induced ECM accumulation not only in a direct manner but also through downstream effectors . Regulation EDN1 EDN2 10455291 638658 The *effects* of endothelin (ET)-1 ( 1-31 ) and ( 1-31 ) , human chymase products of the corresponding big ETs , on the intracellular free Ca2+ concentration ([Ca2+]i) and [ 125I ] [-ET-1] binding were investigated using human cultured bronchial smooth muscle cells ( BSMC ) . Regulation EDN1 EDN2 17629402 1775211 MnCl ( 2 ) up-regulated gene expression and ET-2/VIC peptide production as CoCl ( 2 ) did , but not *affect* [ET-1] gene expression , in the neurite outgrowth of PC12 cells . Regulation EDN1 EDN2 17660396 1799081 Altered *role* of smooth muscle receptors in coronary [endothelin-1] and alpha1-adrenoceptor mediated vasoconstriction in Type 2 diabetes . Regulation EDN1 EDN2 21515378 2449063 [ET-1] induced Elevation of intracellular calcium in clonal neuronal and embryonic kidney cells *involves* endogenous receptors linked to phospholipase C through Ga ( q/11 ) . Regulation EDN1 EDN2 8621208 359405 Moreover , the production of appears to be regulated at the mRNA transcription level , and expressions of [ET-1] and ET-3 are *regulated* independently . Regulation EDN1 EDN2 9600642 506476 The results demonstrate that [endothelin-1] binds to brush border membranes , and that ET ( B ) receptors may be *involved* in the previously described effects of endothelin-1 on brush border membrane Na+ transport . Regulation EDN1 EPHB2 19575782 2111493 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Regulation EDN1 FOXO1 19887561 2188372 We conclude that EGCG decreases ET-1 expression and secretion from endothelial cells , in part , via Akt- and AMPK stimulated *regulation* of the [ET-1] promoter . Regulation EDN1 IL1B 18524861 1939832 The *effect* of on [ET-1] release could be partially inhibited by pretreatment of IMCD-3 cells with an inhibitor of NF-kappaB activation ( BAY 11-7082 ) . Regulation EDN1 IL1B 9687319 522187 The *effects* of LH , ET-1 , TNFalpha , and on the local release of steroids , prostaglandin E2 ( PGE2 ) , and [ET-1] from the cells surrounding the implanted capillary membrane were investigated . Regulation EDN1 PLAT 1644323 194865 We have examined the hypothesis that the release of may *play* a prominent role in [endothelin] induced gastric mucosal injury . Regulation EDN1 TGM2 19635990 2138083 *Involvement* of in [endothelin 1-induced] hypertrophy in cultured neonatal rat cardiomyocytes . Regulation EDN1 TNF 1381725 196100 However , cotreatment with IFN-gamma potentiated the stimulatory *effect* of on BAEC [ET-1] mRNA transcript levels and ET release . Regulation EDN1 TNF 15652492 1364240 We investigated the *effect* of on interleukin-8 (IL-8) and [endothelin-1 (ET-1)] expression , and their different signal transduction pathways . Regulation EDN1 TNF 1566813 186855 Transcriptional *regulation* of the [endothelin-1] gene by . Regulation EDN1 TNF 1566813 186861 Furthermore , augmented [ET-1] expression in *response* to was evident in bovine glomerular mesangial cells . Regulation EDN1 TNF 1583403 187629 Many of the renal effects of TNF are similar to those caused by ET-1 , but the *effect* of on mesangial cell [ET-1] production is unknown . Regulation EDN1 TNF 1583403 187630 The current study examined the *effect* of on [ET-1] synthesis and release by mesangial cells . Regulation EDN1 TNF 1583403 187633 The stimulatory *effect* of on [ET-1] release is not a general property of ET-1 producing cells because proximal tubule , medullary thick ascending limb , cortical collecting tubule , and inner medullary collecting duct cells did not increase ET-1 production on exposure to TNF . Regulation EDN1 TNF 18475471 209534 We have studied the *effect* of human recombinant on gene expression and production of [endothelin-1] in cultured bovine aortic endothelial cells . Regulation EDN1 TNF 19850966 2170299 [ET-1] and granulocyte-macrophage colony stimulating factor ( GM-CSF ) expression in *response* to and ET-1 stimulation was investigated , and the impact of mitogen activated protein kinase (MAPK) pathways in this context was studied . Regulation EDN1 TNF 22249931 2569498 Bosentan , an endothelin receptor antagonist , ameliorates collagen induced arthritis : the *role* of in the induction of [endothelin] system genes . Regulation EDN1 TNF 7938900 276229 Results suggest that is *involved* in the production of [ET-1] and TM . Regulation EDN1 TNF 8425178 210946 Among the agents tested , estrogen , tamoxifen , , gamma-interferon , interleukin (IL) 1 , and transforming growth factor beta had no *effect* on [ir-ET-1] secretion by these breast cancer cells . Regulation EDN1 TNF 8747795 344099 is *involved* in the production of [endothelin-1] and thrombomodulin , which play a role in the pathogenesis of DIC and whose blood levels reflect its severity . Regulation EDN1 TNF 8982535 403872 may be *involved* in the production of [ET-1] and TM . Regulation EDN1 TNF 9196868 438476 In view of the probable immune bases for vascular injury in connective tissue disorders , we examined the *effect* of the cytokines IL-1 alpha , IL-4 , IL-6 , and lymphotoxin on the production of [ET-1] by cultured vascular endothelial cells . Regulation EDN1 TNF 9466472 485589 We hypothesized that endothelin (ET) may be released in *response* to and that platelet activating factor (PAF) and cyclooxygenase products modulate TNF induced [ET-1] release in vivo . Regulation EDN1 TNF 9533826 511047 *Regulation* of [endothelin-1] in human non pigmented ciliary epithelial cells by . Regulation EDN1 TNF 9533826 511049 Cycloheximide ( 9 micron ) , a protein synthesis inhibitor , decreased TNF-alpha stimulated levels for ir-ET-1 and ir-Big ET-1 , suggesting that may be directly *regulating* [ET-1] expression at the ET-1 gene . Regulation EDN1 TNF 9533826 511052 Our data indicates that *regulates* [ET-1] levels in HNPE cells possibly by activating PKC either to stimulate protein synthesis and/or to enhance ET-1 secretion . Regulation EDN1 TNF 9687319 522186 The *effects* of LH , ET-1 , , and IL-1beta on the local release of steroids , prostaglandin E2 ( PGE2 ) , and [ET-1] from the cells surrounding the implanted capillary membrane were investigated . Regulation EDN1 TNF 9696707 524456 Although , LPS , and PAF had no significant *effect* on [ET-1] synthesis , TGF-beta increased ET-1 mRNA expression and irET-1 secretion . Regulation EDN2 ACE 1316980 187848 Although angiotensin II and had no significant *effect* on [endothelin] release , concentration dependent suppression occurred with bradykinin and sodium nitroprusside . Regulation EDN2 ACE 9488241 476561 Circulating endothelin levels did not differ significantly among patients with essential hypertension , hypertension with renal artery stenosis and proven renovascular hypertension and , although the renin-angiotensin system was clearly activated in members of the renovascular hypertension group , inhibition did not *affect* their [endothelin] levels . Regulation EDN2 ADRBK1 19748906 2186589 [Endothelin] signalling in arterial smooth muscle is tightly *regulated* by . Regulation EDN2 AGTR1 16391174 1520194 The purpose of this study was to determine the *role* of activation on [endothelin] production induced by serum from pregnant rats exposed to reductions in uterine perfusion . Regulation EDN2 ANGPT2 17166491 1679129 These findings demonstrate that changes in dietary fat intake modulate vascular reactivity in *response* to and ROS , as well as expression of vascular angiotensin and [endothelin] receptors . Regulation EDN2 APOB 11549348 856816 In the present study , we have investigated the *effect* of native LDL ( nLDL ) and oxidatively modified ( oxLDL ) on ET-1 synthesis and [endothelin] receptor expression in cultured human coronary artery smooth muscle cells and human monocyte derived macrophages . Regulation EDN2 APOB 12839269 1108043 We also discuss *regulation* of [endothelin] by angiotensin II , reactive oxygen species , thrombin , aging , and in the cardiovascular system . Regulation EDN2 APOB 16740996 1566576 Although it has been previously shown that hypercholesterolemia stimulates the endothelin system , the *effects* of increased levels of on endothelial [endothelin] receptors have not been previously studied . Regulation EDN2 APOB 8929252 386375 The aim of this study was to determine how oxidized *affects* [endothelin] secretion by endothelial cells , monocytes and macrophages . Regulation EDN2 APOB 8929252 386384 Overall , the present findings argue against a stimulatory *effect* of oxidized on [endothelin] release as contributing to increased vasoreactivity in atherosclerosis . Regulation EDN2 ATM 10993124 733431 We suggest the *effect* of on the reduction of [endothelin] has a different pathway from angiotensin converting inhibitor and that ATA seems to be a useful agents for congestive heart failure due to viral myocarditis . Regulation EDN2 AVP 16011011 1431541 The *effect* of on [endothelin] production in the human forearm vascular bed . Regulation EDN2 AVP 16011011 1431547 In another group the *effects* of on [endothelin] production were studied after a prior infusion of L-NG-monomethyl-arginine ( L-NMMA ) , a nitric oxide-synthase inhibitor . Regulation EDN2 CALM3 7525613 276955 The present findings that regulators of cAMP dependent protein kinases , protein kinase C , , and protein phosphatase 2A all *affect* [endothelin] secretion suggest that endothelin secretion is controlled by phosphorylation/dephosphorylation of as yet unidentified regulatory proteins within the cell . Regulation EDN2 CAV1 20026011 2200270 The *role* of beta ( 1 ) interaction in [endothelin] signaling through Galpha subunits . Regulation EDN2 CDC73 2689821 123959 Thus , [endothelin] is a highly toxic peptide with cardiotoxic effects , and may be *involved* in the pathogenesis of the sudden death . Regulation EDN2 CTR9 2689821 123960 Thus , [endothelin] is a highly toxic peptide with cardiotoxic effects , and may be *involved* in the pathogenesis of the sudden death . Regulation EDN2 CTSE 1731782 181379 The *effects* of novel inhibitors on the big [endothelin] pressor response in conscious rats . Regulation EDN2 ECE1 9207226 440748 Therefore , VEGF increased ECE-1 expression in BAEC , which suggests that induction by VEGF may be *involved* in [endothelin-system] upregulation under pathological conditions such as neointimal formation and atherosclerosis . Regulation EDN2 EDN1 10422763 632380 We examined the role of diabetes duration on [endothelin-] plasma levels and vasoconstrictor *responses* to in aortic rings from streptozotocin induced diabetic rats . Regulation EDN2 EDN1 16318777 1487709 To study the *effect* of and its antagonists on the expression of [endothelin] and its receptors mRNA in HSC-T6 cells . Regulation EDN2 EDN1 21057729 2344653 Recent studies have demonstrated that [endothelin] receptor up-regulation mediates vascular and airway hyper-reactivity in *response* to ( ET-1 , endothelin receptor agonist ) in cardiovascular and airway diseases . Regulation EDN2 EDN1 22209790 2544312 In intestinal villi , fibroblasts-like cells express [endothelin] 's receptors and *response* to and ET-3 peptides , changing their cellular shape . Regulation EDN2 EDN1 23662699 2800772 [Endothelin] receptors in augmented vasoconstrictor *responses* to in chronic intermittent hypoxia . Regulation EDN2 EDN1 7692154 231087 Mesenteric artery and cardiac ventricular [endothelin] receptors and induced pressor *responses* were studied in normal rats and rats with chronic congestive heart failure induced by myocardial ischemia ( 4 weeks after coronary artery ligation ) . Regulation EDN2 EDN1 7844086 294138 To investigate the *role* of in the pathogenesis of bronchial asthma and the effect of immunotherapy ( IT ) on [endothelin] production , we measured the in vivo and in vitro production of ET-1 in 24 asthmatic children before and after specific allergen IT for 2 years as well as in age matched healthy controls . Regulation EDN2 EDN1 8581288 341170 Roles of [endothelin] receptors in the regional and systemic vascular *responses* to in the anaesthetized ganglion blocked rat : use of selective antagonists . Regulation EDN2 EDN1 8884216 391004 These findings indicate that 1 ) [endothelin] receptor blockade produces beneficial effects on renal haemodynamics in rats with experimental congestive heart failure and 2 ) may be *involved* in the pathogenesis of renal hypoperfusion only in decompensated congestive heart failure . Regulation EDN2 EDN1 9039082 415694 These results indicate that *acts* on [endothelin] type A receptors and inhibits nitric oxide synthesis in interleukin-1 beta stimulated vascular smooth muscle cells at least partially through a protein kinase C-dependent pathway . Regulation EDN2 EDN3 22209790 2544313 In intestinal villi , fibroblasts-like cells express [endothelin] 's receptors and *response* to ET-1 and peptides , changing their cellular shape . Regulation EDN2 EDN3 7806063 292505 Unlabeled ET-1 , ET-2 , and ET-3 inhibited the specific binding of 125I-ET-1 in a concentration dependent manner , but the inhibitory *effect* of was smaller than those of ET-1 and [ET-2] . Regulation EDN2 EDNRA 15106802 1240562 The [endothelin] receptor expression pattern and the blood pressure *responses* to and ETB receptor antagonists could not explain the lack of hypertension in ET-1 transgenic mice . Regulation EDN2 EDNRA 9325182 456740 Angiotensin II increases vascular and renal endothelin-1 and functional endothelin converting enzyme activity in vivo : *role* of receptors for [endothelin] regulation . Regulation EDN2 EDNRB 8587353 341645 mediated contraction of human and rat pulmonary resistance arteries and the *effect* of pulmonary hypertension on [endothelin] responses in the rat . Regulation EDN2 EPHB2 19575782 2111507 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Regulation EDN2 EPX 7763199 308230 This study was designed to explore the presence , if any , of fast acting *effects* of on the arterial blood pressure and [endothelin] level in vivo . Regulation EDN2 EPX 9056686 417476 We therefore investigated the *effects* of on [endothelin (ET)] synthesis and cytosolic free calcium concentration ( [ Ca2+ ] i ) in vascular endothelial cells . Regulation EDN2 FGF2 11956566 767226 The study was undertaken to investigate the *effect* of on aortic production of nitric oxide ( NO ) and [endothelin] of aorta in spontaneously hypertensive rats ( SHR ) and WKY rats . Regulation EDN2 HMOX2 9506613 491445 On the other hand , immunoreactivity was abundant in neurons and was not *affected* by [endothelin] , hemolysate , CO-hemolysate , or saline . Regulation EDN2 HSPG2 8717070 378850 3 . [Endothelin] activation of cPLA2 is sensitive to ambient [Ca2+ ] i , is not contingent upon protein kinase C activation and is *independent* of stimulation , being coupled to the endothelin receptor in a yet to be determined manner . Regulation EDN2 IL2 10341854 616468 We investigated the *effects* of on [endothelin] levels and the hypothalamo-pituitary-adrenal axis . Regulation EDN2 IL2 10341854 616471 We determined the interleukin-6 , [big-endothelin] , endothelin-1 , ACTH , cortisol and AVP *responses* to intravenously and subcutaneously administered in 8 cancer patients in a randomized placebo controlled trial . Regulation EDN2 IL6 16940225 1615439 increased plasma renin activity but did not *affect* [endothelin] in IL-6 treated NP rats . Regulation EDN2 IL8 1901127 154026 Interleukin-1 beta , Interleukin-6 and at various doses did not *affect* [endothelin] secretion . Regulation EDN2 INS 10612552 575582 In this study we evaluated whether *affects* the monocyte derived inflammatory mediator neopterin and [endothelin-] in plasma ( p ) , and NO and PGI2 mediators cyclic 3'-5 ' guanosine monophosphate ( cGMP ) and cyclic 3'-5 ' adenosine monophosphate ( cAMP ) in platelets . Regulation EDN2 INS 1910119 167386 The stimulating *effect* of on retinal capillary [endothelin] was more pronounced in log-phase cells than in stationary-phase cells . Regulation EDN2 LEO1 2689821 123963 Thus , [endothelin] is a highly toxic peptide with cardiotoxic effects , and may be *involved* in the pathogenesis of the sudden death . Regulation EDN2 LRPPRC 19330911 2052615 Here , we investigate whether serum soluble gp130 concentrations correlate with blood pressure in humans , whether expression in the aorta differs between hypertensive and control rats , and whether angiotensin II or [endothelin] *regulate* gp130 expression in human VSMC . Regulation EDN2 MAPK1 18778461 1969194 The *involvement* of PKC and in the [endothelin] receptor regulation was examined by culture in the presence of antagonists . Regulation EDN2 MAPK1 19575782 2111508 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Regulation EDN2 MAPK10 18778461 1969195 The *involvement* of PKC and in the [endothelin] receptor regulation was examined by culture in the presence of antagonists . Regulation EDN2 MAPK10 19575782 2111509 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Regulation EDN2 MAPK11 18778461 1969196 The *involvement* of PKC and in the [endothelin] receptor regulation was examined by culture in the presence of antagonists . Regulation EDN2 MAPK11 19575782 2111510 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Regulation EDN2 MAPK12 18778461 1969197 The *involvement* of PKC and in the [endothelin] receptor regulation was examined by culture in the presence of antagonists . Regulation EDN2 MAPK12 19575782 2111511 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Regulation EDN2 MAPK13 18778461 1969198 The *involvement* of PKC and in the [endothelin] receptor regulation was examined by culture in the presence of antagonists . Regulation EDN2 MAPK13 19575782 2111512 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Regulation EDN2 MAPK14 18778461 1969199 The *involvement* of PKC and in the [endothelin] receptor regulation was examined by culture in the presence of antagonists . Regulation EDN2 MAPK14 19575782 2111513 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Regulation EDN2 MAPK15 18778461 1969193 The *involvement* of PKC and in the [endothelin] receptor regulation was examined by culture in the presence of antagonists . Regulation EDN2 MAPK15 19575782 2111506 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Regulation EDN2 MAPK3 18778461 1969200 The *involvement* of PKC and in the [endothelin] receptor regulation was examined by culture in the presence of antagonists . Regulation EDN2 MAPK3 19575782 2111514 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Regulation EDN2 MAPK4 18778461 1969201 The *involvement* of PKC and in the [endothelin] receptor regulation was examined by culture in the presence of antagonists . Regulation EDN2 MAPK4 19575782 2111515 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Regulation EDN2 MAPK6 18778461 1969202 The *involvement* of PKC and in the [endothelin] receptor regulation was examined by culture in the presence of antagonists . Regulation EDN2 MAPK6 19575782 2111516 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Regulation EDN2 MAPK7 18778461 1969203 The *involvement* of PKC and in the [endothelin] receptor regulation was examined by culture in the presence of antagonists . Regulation EDN2 MAPK7 19575782 2111517 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Regulation EDN2 MAPK8 18778461 1969204 The *involvement* of PKC and in the [endothelin] receptor regulation was examined by culture in the presence of antagonists . Regulation EDN2 MAPK8 19575782 2111518 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Regulation EDN2 MAPK9 18778461 1969205 The *involvement* of PKC and in the [endothelin] receptor regulation was examined by culture in the presence of antagonists . Regulation EDN2 MAPK9 19575782 2111519 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Regulation EDN2 MAPKAP1 1725351 176820 The basal production of [endothelin] was not *affected* by L-NMMA or by , but was significantly increased in the presence of thrombin under both experimental conditions . Regulation EDN2 MME 7681910 214396 *Effects* of inhibition on the clearance of exogenously administered [endothelin] in Sprague-Dawley rats . Regulation EDN2 MRXS5 11139776 780194 The purpose of this study was to evaluate the *effect* of luteinizing hormone ( LH ) , steroids , and peptides on the oviductal contraction and secretion of PGs and [endothelin] ( ET-1 ) . Regulation EDN2 NOS1 1625017 191606 An l-arginine analog inhibitor of , L-NG-monomethyl arginine ( L-NMMA , 200 microM ) , did not significantly *affect* basal immunoreactive [endothelin] levels . Regulation EDN2 NOS1 9578518 503290 *Role* of in release of [endothelin] from cultured human endometrial cells . Regulation EDN2 NOS2 1625017 191607 An l-arginine analog inhibitor of , L-NG-monomethyl arginine ( L-NMMA , 200 microM ) , did not significantly *affect* basal immunoreactive [endothelin] levels . Regulation EDN2 NOS2 9578518 503291 *Role* of in release of [endothelin] from cultured human endometrial cells . Regulation EDN2 NOS3 1625017 191608 An l-arginine analog inhibitor of , L-NG-monomethyl arginine ( L-NMMA , 200 microM ) , did not significantly *affect* basal immunoreactive [endothelin] levels . Regulation EDN2 NOS3 9578518 503292 *Role* of in release of [endothelin] from cultured human endometrial cells . Regulation EDN2 NPPA 9222873 291180 This study investigated the *effect* of on [endothelin (ET)] secretion from cultured human endothelial cells . Regulation EDN2 NPY 9630349 512338 These data indicate that the induced *effect* does not involve either the endothelium derived vasodilator nitric oxide or the vasoconstrictor [endothelin] . Regulation EDN2 PAF1 2689821 123961 Thus , [endothelin] is a highly toxic peptide with cardiotoxic effects , and may be *involved* in the pathogenesis of the sudden death . Regulation EDN2 PI3 21208279 2374395 *play* an important role in the C3b induced release of ECP , EPO and [EPX/EDN] , whereas protein kinase C seems to have inhibitory effects on C3b induced degranulation . Regulation EDN2 PLAT 1644323 194866 We have examined the hypothesis that the release of may *play* a prominent role in [endothelin] induced gastric mucosal injury . Regulation EDN2 PTGS2 18516093 1918467 Taken together , we believe that hypoxia , but not the PR or , *regulate* gonadotropin induced [EDN2] expression in the periovulatory follicle . Regulation EDN2 REN 18407094 209515 Recent reports , however , suggest that [endothelin] may affect the release of the pituitary hormones and *control* the levels of atrial natriuretic peptide , , and the catecholamines . Regulation EDN2 REN 2045149 160267 Basal release was 0.62 +/- 0.15 ng angiotensin I/hr/afferent arterioles/hr ( n = 13 ) and was not *affected* by [endothelin] ( 10 ( -10 ) to 10 ( -6 ) M ) . Regulation EDN2 RLN1 19101597 2053704 Native porcine , but not the modified peptide *affected* RXFP1 dependent and GR-independent readouts : ERK-1/2 and Akt phosphorylation as well as up-regulation of Akt and [endothelin] type-B receptor . Regulation EDN2 RLN2 19101597 2053705 Native porcine , but not the modified peptide *affected* RXFP1 dependent and GR-independent readouts : ERK-1/2 and Akt phosphorylation as well as up-regulation of Akt and [endothelin] type-B receptor . Regulation EDN2 RLN3 19101597 2053706 Native porcine , but not the modified peptide *affected* RXFP1 dependent and GR-independent readouts : ERK-1/2 and Akt phosphorylation as well as up-regulation of Akt and [endothelin] type-B receptor . Regulation EDN2 TGFB1 11210004 785616 *regulation* of [endothelin] expression in rat vascular cell and organ cultures . Regulation EDN2 TGFB1 11343419 813945 Combined Angiotensin and [Endothelin] Receptor Blockade Attenuates Adverse Cardiac Remodeling Post-Myocardial Infarction in the Rat : Possible *Role* of . Regulation EDN2 TGFB1 2649101 108845 These results suggest that , secreted by activated platelets , is *involved* not only in wound healing , but in the regulation of local vascular tone by stimulating [endothelin] production in the endothelial cells . Regulation EDN2 TGFB2 11210004 785617 *regulation* of [endothelin] expression in rat vascular cell and organ cultures . Regulation EDN2 TGFB3 11210004 785618 *regulation* of [endothelin] expression in rat vascular cell and organ cultures . Regulation EDN2 TNF 10750028 681352 Studies using receptor selective TNFalpha mutants , ( 125 ( I-TNFalpha binding and TNF receptor mRNA showed that type-1 TNF receptors mediate the [ET-2] *response* to . Regulation EDN2 TNF 22249931 2569499 Bosentan , an endothelin receptor antagonist , ameliorates collagen induced arthritis : the *role* of in the induction of [endothelin] system genes . Regulation EDN2 TNF 9466472 485590 We hypothesized that [endothelin (ET)] may be released in *response* to and that platelet activating factor (PAF) and cyclooxygenase products modulate TNF induced ET-1 release in vivo . Regulation EDN2 TNF 9595397 505940 Comparison of the *regulation* of [endothelin-2] and endothelin converting enzyme-1 b [ correction of beta ] by forskolin and in ACHN cells . Regulation EDN2 VEGFA 9207226 440747 Therefore , VEGF increased ECE-1 expression in BAEC , which suggests that ECE-1 induction by may be *involved* in [endothelin-system] upregulation under pathological conditions such as neointimal formation and atherosclerosis . Regulation EDN2 WDR61 2689821 123962 Thus , [endothelin] is a highly toxic peptide with cardiotoxic effects , and may be *involved* in the pathogenesis of the sudden death . Regulation EDN3 EDN2 8621208 359408 Moreover , the production of appears to be regulated at the mRNA transcription level , and expressions of ET-1 and [ET-3] are *regulated* independently . Regulation EDN3 EPHB2 19575782 2111521 *Role* of in [endothelin] receptor signaling in human aortic smooth muscle cells . Regulation EDN3 PLAT 1644323 194867 We have examined the hypothesis that the release of may *play* a prominent role in [endothelin] induced gastric mucosal injury . Regulation EDN3 TNF 22249931 2569500 Bosentan , an endothelin receptor antagonist , ameliorates collagen induced arthritis : the *role* of in the induction of [endothelin] system genes . Regulation EDN3 TNF 9466472 485591 We hypothesized that [endothelin (ET)] may be released in *response* to and that platelet activating factor (PAF) and cyclooxygenase products modulate TNF induced ET-1 release in vivo . Regulation EDNRA EDN2 18511039 1922411 Thus , IL-18 , IFN-gamma , *acting* on endothelin [ETA] and ETB receptors , and prostanoids mediate PBQ induced writhing response in mice . Regulation EDNRA EDN2 8739217 377082 In most organs of the body , *acts* on endothelin [ETA] and ETB receptors that co-exist ( albeit often on different cell types ) . Regulation EDNRA TNF 10229544 611048 These findings suggest that [ETA] *regulates* TNF production in murine lung by suppressing LPS receptor expression , mRNA expression and protein synthesis and/or secretion of . Regulation EDNRB EDN2 18511039 1922414 Thus , IL-18 , IFN-gamma , *acting* on endothelin ETA and [ETB] receptors , and prostanoids mediate PBQ induced writhing response in mice . Regulation EDNRB EDN2 8739217 377085 In most organs of the body , *acts* on endothelin ETA and [ETB] receptors that co-exist ( albeit often on different cell types ) . Regulation EDNRB EDN2 8854203 388057 In the renal vasculature of anesthetized rats , it is suggested that vasoconstriction is mediated through both endothelin ETA- and ETB-receptors and that endothelin [ETB-receptors] may be also involved in vasodilating *responses* to peptides . Regulation EEC1 FAS 18342935 1886547 Since Fas and Fas ligand (FasL) are expressed in EEC and trophoblast cells respectively and mitogen activated protein kinases ( MAPKs ) mediate Fas induced apoptosis , the *roles* of and MAPK signaling in [trophoblast-EEC] interactions were studied . Regulation EEF1A2 MUC16 11249777 764217 In murine and human studies , the vaccine has been shown to stimulate [anti-STn] antibodies and T-cell *responses* . Regulation EFNA1 TNF 11278471 802584 In this study , we investigated the signaling mechanisms of *dependent* induction of [ephrin A1] in endothelial cells . Regulation EFNB1 CTNNB1 12408869 1010328 We show here that and TCF inversely *control* the expression of the EphB2/EphB3 receptors and their ligand [ephrin-B1] in colorectal cancer and along the crypt-villus axis . Regulation EFNB1 TAZ 19995908 2191155 [Ephrin B1] *regulates* bone marrow stromal cell differentiation and bone formation by influencing transactivation via complex formation with NHERF1 . Regulation EFNB1 TCF12 12408869 1010319 We show here that beta-catenin and inversely *control* the expression of the EphB2/EphB3 receptors and their ligand [ephrin-B1] in colorectal cancer and along the crypt-villus axis . Regulation EFNB1 TCF15 12408869 1010320 We show here that beta-catenin and inversely *control* the expression of the EphB2/EphB3 receptors and their ligand [ephrin-B1] in colorectal cancer and along the crypt-villus axis . Regulation EFNB1 TCF19 12408869 1010321 We show here that beta-catenin and inversely *control* the expression of the EphB2/EphB3 receptors and their ligand [ephrin-B1] in colorectal cancer and along the crypt-villus axis . Regulation EFNB1 TCF20 12408869 1010322 We show here that beta-catenin and inversely *control* the expression of the EphB2/EphB3 receptors and their ligand [ephrin-B1] in colorectal cancer and along the crypt-villus axis . Regulation EFNB1 TCF21 12408869 1010323 We show here that beta-catenin and inversely *control* the expression of the EphB2/EphB3 receptors and their ligand [ephrin-B1] in colorectal cancer and along the crypt-villus axis . Regulation EFNB1 TCF23 12408869 1010327 We show here that beta-catenin and inversely *control* the expression of the EphB2/EphB3 receptors and their ligand [ephrin-B1] in colorectal cancer and along the crypt-villus axis . Regulation EFNB1 TCF24 12408869 1010330 We show here that beta-catenin and inversely *control* the expression of the EphB2/EphB3 receptors and their ligand [ephrin-B1] in colorectal cancer and along the crypt-villus axis . Regulation EFNB1 TCF25 12408869 1010329 We show here that beta-catenin and inversely *control* the expression of the EphB2/EphB3 receptors and their ligand [ephrin-B1] in colorectal cancer and along the crypt-villus axis . Regulation EFNB1 TCF3 12408869 1010324 We show here that beta-catenin and inversely *control* the expression of the EphB2/EphB3 receptors and their ligand [ephrin-B1] in colorectal cancer and along the crypt-villus axis . Regulation EFNB1 TCF4 12408869 1010325 We show here that beta-catenin and inversely *control* the expression of the EphB2/EphB3 receptors and their ligand [ephrin-B1] in colorectal cancer and along the crypt-villus axis . Regulation EFNB1 TCF7 12408869 1010326 We show here that beta-catenin and inversely *control* the expression of the EphB2/EphB3 receptors and their ligand [ephrin-B1] in colorectal cancer and along the crypt-villus axis . Regulation EGF EPHB2 16327976 1503568 Furthermore , the hepatocyte growth factor and [epidermal growth factor] induced Mcl-1 expression in an Akt- and *dependent* manner . Regulation EGF EPHB2 17332776 1726560 Interferon alpha (IFNalpha) induces both apoptosis and a counteracting [epidermal growth factor] *dependent* survival response in cancer cells . Regulation EGF EPHB2 24217646 2865011 In addition , [EGF] suppressed the expression of MF differentiation markers in these cells in a *dependent* manner , and , moreover , stimulated the cell migration in a MEK/ERK dependent manner . Regulation EGF HBEGF 10425274 632817 These results indicate that EGF and possess different functions in RGM-1 cells and that [EGF] *acts* as a mediator of both cell maturation and apoptosis in these cells . Regulation EGF HBEGF 11116149 810665 BB2116 as well as HB-EGF neutralizing antibody inhibited the EGF receptor transactivation by AngII , suggesting a critical *role* of in the metalloprotease dependent [EGF] receptor transactivation . Regulation EGF HBEGF 1306684 209022 The inhibitory *effect* of on [125I-EGF] binding was reversed either in the presence of heparin ( but not by chondroitin sulfate ) or by pre treating the cells with heparinase . Regulation EGF MAP2K6 24217646 2865017 In addition , [EGF] suppressed the expression of MF differentiation markers in these cells in a *dependent* manner , and , moreover , stimulated the cell migration in a MEK/ERK dependent manner . Regulation EGF MMP7 22089237 2514189 We show that elevated levels of and a disintegrin and metalloproteinase-12 ( ADAM12 ) in a ( 1a ) -247R expressing cells are *responsible* for [EGF receptor (EGFR)] transactivation , downstream ERK activation , and increased cell proliferation ; Regulation EGF TNF 1551065 184039 In a fifth neoplastic cell line ( papillary carcinoma , NPA ) that constitutively expressed surface DR , its expression was inhibited by both alpha-IFN and and was not *affected* by [EGF] . Regulation EGF TNF 1658009 169004 alpha and [epidermal growth factor] *regulation* of collagenase and stromelysin in adult porcine articular chondrocytes . Regulation EGF TNF 22116041 2541355 However , as it is known that Cbl deficiency damages myelin by increasing and decreasing epidermal growth factor (EGF) levels in rat spinal cord ( SC ) , and that TNF-a and [EGF] *regulate* PrP ( C ) expression in vitro , we investigated whether Cbl deficiency modifies SC PrP ( C ) and PrP ( C ) -mRNA levels in Cbl-D rats . Regulation EGF TNF 2555361 122016 Quantitation of receptors expressed on the surface of ME-180 and T24 cells demonstrated a 3-fold difference between the number of EGF binding sites on T24 ( 100,000 ) versus ME-180 cells ( 300,000 ) , suggesting the relative abundance of EGF receptor does not solely account for differential *effects* of on [EGF] receptor activation in these two cell lines . Regulation EGF TNF 8518234 222098 Overall , these results suggest that expression of [EGF] receptor protein , its intrinsic tyrosine kinase activity , or its phosphotyrosine content may alter TNF cytotoxic signal transduction and *control* responsiveness within the ME-180 cell line . Regulation EGF TNF 8917420 396123 In this study , we investigated the modulatory *effect* of on [EGF] receptor of a human hepatocellular carcinoma cell line-HepG2 . Regulation EGF TNF 8917420 396124 The modulatory *effect* of on the [EGF] receptor of HepG2 cells exhibited its unique characteristics in comparison with the previous reports on other tumor cells . Regulation EGF TNF 8917420 396125 Therefore , the *effect* of on [EGF] receptor tyrosine phosphorylation in HepG2 cells was due to enhancing the receptor 's response to EGF . Regulation EGFR ARSA 16082388 1507057 We here examined the *effect* of <5-ASA> on [epidermal growth factor receptor (EGFR)] activation , a pathway that triggers mitogenic signals in CRC cells . Regulation EGFR EDN2 22671705 2626146 Specifically , we establish that the inhibitory effects exerted by endothelins on basal as well as EGF induced expression of the major astroglial glutamate transporter subtype , glutamate transporter 1 , are a direct consequence of the *dependent* retention of the [EGFR] at the cell surface . Regulation EGFR FAS 15660394 1375906 Hyperosmolarity- and CD95 ligand (CD95L) induced interactions between CD95 ( Fas/APO-1 ) and the [epidermal growth factor receptor (EGFR)] *involve* EGFR catalyzed tyrosine phosphorylation . Regulation EGFR FAS 15660394 1375915 CD95 mutants with tyrosine-phenylalanine exchanges at positions 232 and 291 failed to translocate to the plasma membrane and to recruit Fas associated death domain and caspase 8 , although these mutants still associated with the [EGFR] in the cytosol in *response* to hyperosmolarity and . Regulation EGFR FAS 18471522 1910397 CD95L induced EGFR and Erk phosphorylation were abolished after proteinase inhibition by GM6001 and in the presence of neutralizing epidermal growth factor antibodies , suggestive of a ligand dependent [EGFR] phosphorylation in *response* to . Regulation EGFR FAS 19141676 2025742 No significant genetic interactions were detected with the Notch , Wingless , Hedgehog or Dpp pathways , nor did Fas2 inhibit the FGF receptor or Torso , indicating specificity in the inhibitory *role* of in [EGFR] signalling . Regulation EGFR HBEGF 12972402 1218206 Neutralizing antibodies against EGFR ligands revealed the *involvement* of in Zn ( 2+ ) -induced [EGFR] phosphorylation . Regulation EGFR HBEGF 14647423 1201898 Moreover , we report that the [EGFR] transactivation signal *involves* the EGFR ligands amphiregulin , and TGFalpha as well as the metalloproteinases ADAM 10 , 15 and 17 , depending on the cellular system . Regulation EGFR HBEGF 17001310 1716326 These results suggest that the chemotherapy induced [EGFR] activation is *regulated* by . Regulation EGFR HBEGF 17395697 1748531 [Epidermal growth factor (EGF) receptor] ligands in the chicken ovary : I. Evidence for heparin binding EGF-like growth factor ( HB-EGF ) as a potential oocyte derived signal to *control* granulosa cell proliferation and and kit ligand expression . Regulation EGFR HBEGF 20139904 2208094 The epoxyeicosatrienoic acid stimulated phosphorylation of [EGF-R] *involves* the activation of metalloproteinases and the release of in cancer cells . Regulation EGFR HBEGF 23349960 2734139 Erlotinib blocks the activation of the [epidermal growth factor receptor (EGFR)] in *response* to . Regulation EGFR MAP2K6 8662819 367342 *Role* of in regulation of the [epidermal growth factor receptor] by protein kinase C . Regulation EGFR MMP28 14656925 1188499 Focusing on alpha ( 1b ) -adrenoceptors , we suggest here that *dependent* activation of the [EGFR] promotes vasoconstriction as well as growth . Regulation EGFR MMP28 15928312 1458591 These observations in adrenal glomerulosa and hepatic cells demonstrate that LPA phosphorylates ERK1/2 through [EGF-R] transactivation in a *dependent* or -independent manner in individual target cells . Regulation EGFR MMP28 17113976 1651224 Consistent with this , inhibition of matrix metalloproteinases ( MMPs ) with GM6001 reduced ERK1/2 activation by ET-1 , consistent with partial involvement of the *dependent* [EGF-R] activation in this cascade . Regulation EGFR MMP28 18288638 1911836 Furthermore , Fra-1 induced [EGFR] phosphorylation in an *dependent* manner , and an EGFR-specific inhibitor was able to block Fra-1 enhanced cell motility and invasion . Regulation EGFR MMP28 18986098 1983725 The inhibitors also abolished leptin induced proliferation as well as leptin induced EGFR tyrosine phosphorylation , but did not *affect* proliferation or [EGFR] activation induced by TGFalpha . Regulation EGFR MMP28 19225051 2061738 Taken together , these results indicate that osmotic stress induces *dependent* activation of [EGFR] , likely via shedding of TGF-alpha , and downstream activation of Ras and the MAP kinases p38 and ERK1/2 , which stimulate TonEBP transactivation activity . Regulation EGFR MMP28 22792188 2628446 This study reports for the first time that Egr-1 induction by IL-1beta involves EGFR and *dependent* [EGFR] phosphorylation . Regulation EGFR MMP7 14656925 1188514 Focusing on alpha ( 1b ) -adrenoceptors , we suggest here that *dependent* activation of the [EGFR] promotes vasoconstriction as well as growth . Regulation EGFR MMP7 15928312 1458606 These observations in adrenal glomerulosa and hepatic cells demonstrate that LPA phosphorylates ERK1/2 through [EGF-R] transactivation in a *dependent* or -independent manner in individual target cells . Regulation EGFR MMP7 17113976 1651239 Consistent with this , inhibition of matrix metalloproteinases ( MMPs ) with GM6001 reduced ERK1/2 activation by ET-1 , consistent with partial involvement of the *dependent* [EGF-R] activation in this cascade . Regulation EGFR MMP7 18288638 1911851 Furthermore , Fra-1 induced [EGFR] phosphorylation in an *dependent* manner , and an EGFR-specific inhibitor was able to block Fra-1 enhanced cell motility and invasion . Regulation EGFR MMP7 18986098 1983740 The inhibitors also abolished leptin induced proliferation as well as leptin induced EGFR tyrosine phosphorylation , but did not *affect* proliferation or [EGFR] activation induced by TGFalpha . Regulation EGFR MMP7 19225051 2061753 Taken together , these results indicate that osmotic stress induces *dependent* activation of [EGFR] , likely via shedding of TGF-alpha , and downstream activation of Ras and the MAP kinases p38 and ERK1/2 , which stimulate TonEBP transactivation activity . Regulation EGFR MMP7 22792188 2628483 This study reports for the first time that Egr-1 induction by IL-1beta involves EGFR and *dependent* [EGFR] phosphorylation . Regulation EGFR NT5E 23086814 2690453 Potential prognostic biomarker *regulates* [epidermal growth factor receptor] expression in human breast cancer . Regulation EGFR NT5E 23086814 2690454 EGFR expression can be decreased by suppressing CD73 with an inhibitor or small shRNA , and this effect was reversed by adenosine and NECA ( adenosine A2 receptor agonist ) , which suggested that adenosine is involved in [EGFR] expression *regulated* by ( P < 0.01 ) . Regulation EGFR NT5E 23086814 2690456 We also showed that *regulates* [EGFR] phosphorylation by Src ( P < 0.01 ) . Regulation EGFR NT5E 23086814 2690457 By transcription factor (TF) assay , CD73 was found to regulate some associated TFs activity such as PPAR? , which mediates EGFR expression , although whether PPAR? mediates the *effect* of on [EGFR] expression needs further study . Regulation EGFR PLAU 15816844 1393288 As a result , *dependent* focal adhesion kinase ( FAK ) and integrin mediated [EGFR] signaling are suppressed . Regulation EGFR PLAU 15874933 1405707 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and [epidermal growth factor receptor (EGFR)] in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Regulation EGFR TNF 1744226 171873 Cultured fibroblasts showed no upregulation of EGF-R by TNF-alpha , suggesting a differential *effect* of on [EGF-R] expression on glioma cells and normal cells . Regulation EGFR TNF 18080320 1894774 Pretreatment with calcitriol , enhanced induced EGFR-Src *dependent* ERK activation and tyrosine phosphorylation of the [EGFR] , but abolished the EGFR-Src independent ERK activation . Regulation EGFR TNF 18701712 1950520 This study was undertaken to determine the *effects* of on [EGFR] and ErbB2 activation and intestinal epithelial cell survival . Regulation EGFR TNF 2025882 157398 The *effects* of on [epidermal growth factor (EGF) receptor] tyrosine phosphorylation were investigated in Swiss 3T3 cells , which are sensitive to TNF action . Regulation EGFR TNF 2783320 106856 The *effect* of IL-1 and on [EGF-R] was compared with that of the tumor-promotor PMA which is known to `` transmodulate '' EGF-R affinity by activating protein kinase C which then phosphorylates EGF-R . Regulation EGLN3 ANGPT4 24067973 2863161 ANDV infection in combination with hypoxic conditions resulted in the enhancement of hypoxia-inducible factor 1a (HIF1a) directed VEGF A , , and [EGLN3] transcriptional *responses* . Regulation EGLN3 ATF4 21951999 2502559 These results suggest that PHD1 and [PHD3] *control* the transactivation activity of . Regulation EGLN3 INHBA 22778395 2639715 The prolyl hydroxylase [PHD3] identifies proinflammatory macrophages and its expression is *regulated* by . Regulation EGLN3 PDC 25088999 2954085 Taken together , the study reveals that [PHD3] *regulates* PDH activity in cells by physically interacting with . Regulation EGLN3 PPP3CA 15189990 1256796 This motif is related to calcineurin docking sites in other substrates , such as NFAT and Crz1p , and is required for *regulation* of [Hph1p] by . Regulation EGLN3 PPP3CB 15189990 1256797 This motif is related to calcineurin docking sites in other substrates , such as NFAT and Crz1p , and is required for *regulation* of [Hph1p] by . Regulation EGLN3 PPP3CC 15189990 1256798 This motif is related to calcineurin docking sites in other substrates , such as NFAT and Crz1p , and is required for *regulation* of [Hph1p] by . Regulation EGLN3 SIAH1 15210114 1261889 Here , we demonstrate that the abundance of PHD1 and [PHD3] are *regulated* via their targeting for proteasome dependent degradation by the E3 ubiquitin ligases , under hypoxia conditions . Regulation EGLN3 VEGFA 24067973 2863160 ANDV infection in combination with hypoxic conditions resulted in the enhancement of hypoxia-inducible factor 1a (HIF1a) directed , angiopoietin 4 , and [EGLN3] transcriptional *responses* . Regulation EGR1 EPHB2 11502738 868218 Taken together , these findings demonstrate that Ang II-induced cyclin D1 up-regulation is mediated by the activation and specific interaction of [Egr-1] with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a *dependent* manner , and also involves PI3K and SHP-2 . Regulation EGR1 EPHB2 11591707 883119 [Egr-1/MGRE] binding was induced by GnRH in an *dependent* manner . Regulation EGR1 EPHB2 15910736 1412027 Here , we have analyzed the genetic elements involved in the *regulation* of [Egr-1] gene transcription by and TPA in human hepatoma cells . Regulation EGR1 EPHB2 16115217 1448852 Additionally , chronic blocking of activation *affected* cocaine induced c-Fos and JunB but not [Zif268] expression . Regulation EGR1 EPHB2 17494953 1739447 Further investigation showed that CSE could also stimulate [early growth response-1 (EGR-1)] in an *dependent* manner and that the expression of HSP70 was EGR-1 dependent . Regulation EGR1 EPHB2 19372235 2094573 The effects of ERK pathway ablation on LH biosynthesis underlie this gender-specific phenotype , and the molecular mechanism involves a requirement for *dependent* up-regulation of the transcription factor [Egr1] , which is necessary for LHbeta expression . Regulation EGR1 EPHB2 21559295 2429482 Convulsant doses of a dopamine D1 receptor agonist result in *dependent* increases in [Zif268] and Arc/Arg3.1 expression in mouse dentate gyrus . Regulation EGR1 EPHB2 22198386 2575042 We demonstrate that induction of [EGR1] *involves* mediated down-regulation of microRNA-191 and phosphorylation of the ETS2 repressor factor (ERF) repressor , which subsequently leaves the nucleus . Regulation EGR1 MAP2K6 11502738 868225 Taken together , these findings demonstrate that Ang II-induced cyclin D1 up-regulation is mediated by the activation and specific interaction of [Egr-1] with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a *dependent* manner , and also involves PI3K and SHP-2 . Regulation EGR1 MAP2K6 23109673 2735540 SphK1 down-regulation also decreased expression , which phosphorylates and activates P38 MAPK , which , in turn , *regulates* [early growth response-1 (Egr-1)] , a transcription factor of mPGES-1 . Regulation EGR1 PRSS21 20947496 2353713 Compared with wild-type controls , GPRC6A ( -/- ) null mice exhibit significantly less ERK activation and [Egr-1] expression in both bone marrow and *response* to pharmacological doses of testosterone in vivo . Regulation EGR1 RCAN1 19124655 2025083 Biochemical and genetic evidence suggested that [Egr1] *controls* expression . Regulation EGR1 SPHK1 23109673 2735539 down-regulation also decreased MKK6 expression , which phosphorylates and activates P38 MAPK , which , in turn , *regulates* [early growth response-1 (Egr-1)] , a transcription factor of mPGES-1 . Regulation EGR1 TNF 1730654 181300 *Regulation* of the [Egr-1] gene by and interferons in primary human fibroblasts . Regulation EGR1 TNF 21212994 2726124 Differential *regulation* of [Egr-1] expression by glucose and in endothelial cells may be an important consideration in the mechanisms linking these factors to the development of vascular dysfunction in metabolic disorders such as diabetes . Regulation EGR1 TNF 7706752 297848 The present studies have examined the *effects* of on the induction of [EGR-1] expression in human myeloid leukemia cells and the potential cytoplasmic signaling cascades that transduce TNF induced signals to the nucleus . Regulation EGR2 HOXB2 9256343 447945 We have previously demonstrated that in r3 and r5 [Krox-20] directly *controls* the transcription of Hoxa-2 and . Regulation EIF2AK2 TNF 24315369 2880131 We report that ß-amyloid oligomers , AD-associated toxins , activate [PKR] in a *dependent* manner , resulting in eIF2a-P , neuronal insulin receptor substrate ( IRS-1 ) inhibition , synapse loss , and memory impairment . Regulation EIF3F FBXO32 18354498 1898498 The initiation factor [eIF3-f] is a major *target* for function in skeletal muscle atrophy . Regulation EIF4B EPHB2 23707523 2806253 The results indicate mTOR independent phosphorylation of S6K1 and 4E-BP1 and suggest *dependent* phosphorylation of [eIF4B] during skeletal muscle contraction . Regulation EIF4B MAP2K6 23707523 2806259 The results indicate mTOR independent phosphorylation of S6K1 and 4E-BP1 and suggest *dependent* phosphorylation of [eIF4B] during skeletal muscle contraction . Regulation EIF4E EPHB2 10212283 607893 and 3 ) *dependent* [eIF4E] phosphorylation but not PI3-kinase dependent p70 ( S6k ) activation correlates with PGF2alpha induced global protein synthesis and bFGF-2 expression in VSMC . Regulation EIF4E EPHB2 14581487 1186951 In addition , CD40 ligation was found to mediate a PI3K- and mammalian target of rapamycin (mTOR) dependent phosphorylation of 4E-BP1 and its subsequent dissociation from the mRNA cap binding protein eIF4E as well as an *dependent* phosphorylation of [eIF4E] , thus promoting translation initiation . Regulation EIF4EBP1 IL1B 19574449 2136760 At the protein level , [4E-BP1] was also up-regulated in *response* to starvation and , and this was blunted by HDLs . Regulation ELANE MUC16 7912511 261969 The purpose of this study was to examine the *effects* of , one of the most plentiful high molecular weight polyanions in the respiratory tracts , on [HLE] activity . Regulation ELAVL1 EPHB2 15371446 1334333 Collectively , our results indicate that PGA2 stabilizes the p21 mRNA through an ERK independent increase in cytoplasmic HuR levels and an *dependent* association of [HuR] with the p21 mRNA . Regulation ELAVL1 EPHB2 23116706 2717438 5-Aminoimidazole-4-carboxamide ribonucleoside stabilizes low density lipoprotein receptor mRNA in hepatocytes via *dependent* [HuR] binding to an AU-rich element . Regulation ELF2 ANGPT1 11967990 938071 These novel findings suggest that *regulates* expression of [NERF2] and its own receptor in hypoxic cells . Regulation ELF4 EPHB2 20802152 2324527 In this study , we show that [ELF4] *controls* the mediated proliferative response by maintaining normal levels of dual-specificity phosphatases 1 and 5 in CD8 ( + ) T cells . Regulation ELK1 EPHB2 16956962 1673368 Finally , we present evidence indicating that SMC phenotypic switching involves multiple active repressor pathways , including Krüppel-like zinc finger type 4 , HERP , and *dependent* phosphorylation of [Elk-1] that act in a complementary fashion . Regulation ELL C1QTNF1 9002605 404754 The results of the present work support the possible *role* of in GA-induced corolla and stem [elongation] . Regulation ELL CAPN8 16824766 1672233 Based on these findings , it is concluded that the may *play* an important role in the control of notochord [elongation] and somite differentiation during Xenopus embryogenesis . Regulation ELL ELOVL4 17304340 1699085 Furthermore , we suggest that is likely *involved* in the [elongation] of C26 and longer fatty acids . Regulation ELL EPHB2 15067199 1231833 Here , we tested the *involvement* of the and p23 in neurite [elongation] by FK506 in human SH-SY5Y cells . Regulation ELL EPHB2 15067199 1231872 Taken together , the results demonstrate the functional *role* for and p23 in the neurite [elongation] activity of FK506 and reveal a novel signal transduction pathway involving p23 activation of ERK . Regulation ELL EPHB2 18676449 1955190 The splice variants of UBF differentially regulate RNA polymerase I transcription [elongation] in *response* to phosphorylation . Regulation ELL IGFBP1 19497977 2120639 These studies reveal that is a common endometrial marker of conceptus elongation in sheep and cattle and most likely *regulates* conceptus [elongation] by stimulating migration and attachment of the trophectoderm . Regulation ELL MIP 21642618 2451040 Considering the important known functions of the cellular actin cytoskeleton in fiber cell differentiation , the interaction of and ERM proteins may *play* an important role in fiber cell morphology , [elongation] , and organization . Regulation ELL PCDH19 18171927 1855817 and TAF1 *regulate* retinal axon initiation and [elongation] in vivo . Regulation ELL PCDH8 18171927 1855822 and TAF1 *regulate* retinal axon initiation and [elongation] in vivo . Regulation ELL STK39 10557072 566102 The UNC-51 of C. elegans *plays* an essential role in axonal [elongation] , and unc-51 mutants exhibit uncoordinated movements . Regulation ELL TMOD1 18984629 1989799 Thus , we propose a model in which and enhancers of actin dynamics synergistically *regulate* [elongation] and shortening of actin filaments at the pointed end . Regulation ELL TP63 15863843 1401304 From these results , we suggest that may be *involved* in the early stage of the remodeling process of the psoriatic epidermis as well as in the [elongation] of the rete ridges . Regulation ELN CTGF 23542855 2767122 The principal aim of this study is to analyze *effect* on [elastin] production in umbilical cord ( UC ) -derived MSCs and to determine optimal timing of treatment to maximize elastin production . Regulation ELN HBEGF 12882762 1150061 *regulates* [elastin] and FGF-2 expression in pulmonary fibroblasts . Regulation ELN HBEGF 12882762 1150074 These data suggest that and FGF-2 act in concert to *regulate* the synthesis of [elastin] in injury/repair situations . Regulation ELN IL1B 12890646 1157268 The present study was undertaken to further explore the molecular mechanisms responsible for the inhibitory *effect* of on [elastin] gene transcription . Regulation ELN TNF 1281483 205703 The down-regulatory *effect* of on [elastin] promoter activity was abolished by co-transfections with a synthetic double stranded AP-1 oligomer . Regulation ELN TNF 1281483 205705 These observations suggest that the inhibitory *effects* of on [elastin] gene expression involve the transcription factor AP-1 . Regulation ELN TNF 20127972 2272276 In *response* to , tenocytes reduced their type I collagen deposition but increased their [elastin] gene expression and highly upregulated their expression for MMP-1 , pro-inflammatory ( TNFalpha , IL-1beta ) and immunoregulatory ( IL-6 , IL-10 ) cytokines . Regulation ELN TNF 7798617 281105 These results suggest that excess ( or other mediator ) produced in C3H/HeN skin ( but not C3H/HeJ skin ) in response to UVB exposure is *involved* in the mast cell increase and partial inhibition of [elastin] increase , but that neither these mediators nor mast cell products are important mediators for the chronic UVB induced increases in neutrophils , glycosaminoglycans , and collagen . Regulation EMD EPHB2 23167467 2700295 Our results suggest that [EMD] stimulates VEGF production partially via TGF-ß1 and FGF-2 in human gingival fibroblasts and that EMD induced VEGF production is *regulated* by , p38 MAPK , and PI3K/Akt pathways . Regulation EMP1 CRK 19192109 2049510 On the basis of the importance of p38 mitogen activated protein kinase (MAPK) in endothelial responses to inflammatory stimuli , we sought to define the *role* of in [EMP] generation and function . Regulation EMP1 MAPK1 21811066 2490346 We investigated the effects of several drugs on EMP generation in human umbilical vein endothelial cells ( HUVECs ) , and the *involvement* of the in [EMP] generation . Regulation EMP1 MAPK10 21811066 2490347 We investigated the effects of several drugs on EMP generation in human umbilical vein endothelial cells ( HUVECs ) , and the *involvement* of the in [EMP] generation . Regulation EMP1 MAPK11 21811066 2490348 We investigated the effects of several drugs on EMP generation in human umbilical vein endothelial cells ( HUVECs ) , and the *involvement* of the in [EMP] generation . Regulation EMP1 MAPK12 21811066 2490349 We investigated the effects of several drugs on EMP generation in human umbilical vein endothelial cells ( HUVECs ) , and the *involvement* of the in [EMP] generation . Regulation EMP1 MAPK13 21811066 2490350 We investigated the effects of several drugs on EMP generation in human umbilical vein endothelial cells ( HUVECs ) , and the *involvement* of the in [EMP] generation . Regulation EMP1 MAPK14 21811066 2490351 We investigated the effects of several drugs on EMP generation in human umbilical vein endothelial cells ( HUVECs ) , and the *involvement* of the in [EMP] generation . Regulation EMP1 MAPK15 21811066 2490345 We investigated the effects of several drugs on EMP generation in human umbilical vein endothelial cells ( HUVECs ) , and the *involvement* of the in [EMP] generation . Regulation EMP1 MAPK3 21811066 2490352 We investigated the effects of several drugs on EMP generation in human umbilical vein endothelial cells ( HUVECs ) , and the *involvement* of the in [EMP] generation . Regulation EMP1 MAPK4 21811066 2490353 We investigated the effects of several drugs on EMP generation in human umbilical vein endothelial cells ( HUVECs ) , and the *involvement* of the in [EMP] generation . Regulation EMP1 MAPK6 21811066 2490354 We investigated the effects of several drugs on EMP generation in human umbilical vein endothelial cells ( HUVECs ) , and the *involvement* of the in [EMP] generation . Regulation EMP1 MAPK7 21811066 2490355 We investigated the effects of several drugs on EMP generation in human umbilical vein endothelial cells ( HUVECs ) , and the *involvement* of the in [EMP] generation . Regulation EMP1 MAPK8 21811066 2490356 We investigated the effects of several drugs on EMP generation in human umbilical vein endothelial cells ( HUVECs ) , and the *involvement* of the in [EMP] generation . Regulation EMP1 MAPK9 21811066 2490357 We investigated the effects of several drugs on EMP generation in human umbilical vein endothelial cells ( HUVECs ) , and the *involvement* of the in [EMP] generation . Regulation ENDOG PGC 21979051 2493021 We showed direct *regulation* of [ENDOG] by ERR-a and ( which are master regulators of mitochondrial and cardiac function ) , interaction of ENDOG with the mitochondrial genome and ENDOG mediated regulation of mitochondrial mass . Regulation ENG TNF 12820370 1103992 Our hypothesis is that [CD105] gene expression in endothelial cells is *regulated* by the multifunctional cytokines and TGF beta 1 . Regulation ENPP1 GALNT2 23500900 2766688 *Role* of in the modulation of [ENPP1] expression , and insulin signaling and action : GALNT2 : a novel modulator of insulin signaling . Regulation ENPP1 PSG1 23848264 2816893 The *effects* of nasal surgery on positional obstructive sleep apnea/hypopnea syndrome ( OSAHS ) patients ( PPs ) and [non-positional OSAHS patients (NPPs)] were different . Regulation ENPP1 PSG1 23848264 2816903 We aimed to determine the PSG data changes after nasal surgery and evaluate the *effect* of nasal surgery on PPs and [NPPs] , respectively . Regulation ENPP1 PSG11 23848264 2816894 The *effects* of nasal surgery on positional obstructive sleep apnea/hypopnea syndrome ( OSAHS ) patients ( PPs ) and [non-positional OSAHS patients (NPPs)] were different . Regulation ENPP1 PSG11 23848264 2816904 We aimed to determine the PSG data changes after nasal surgery and evaluate the *effect* of nasal surgery on PPs and [NPPs] , respectively . Regulation ENPP1 PSG2 23848264 2816895 The *effects* of nasal surgery on positional obstructive sleep apnea/hypopnea syndrome ( OSAHS ) patients ( PPs ) and [non-positional OSAHS patients (NPPs)] were different . Regulation ENPP1 PSG2 23848264 2816905 We aimed to determine the PSG data changes after nasal surgery and evaluate the *effect* of nasal surgery on PPs and [NPPs] , respectively . Regulation ENPP1 PSG3 23848264 2816896 The *effects* of nasal surgery on positional obstructive sleep apnea/hypopnea syndrome ( OSAHS ) patients ( PPs ) and [non-positional OSAHS patients (NPPs)] were different . Regulation ENPP1 PSG3 23848264 2816906 We aimed to determine the PSG data changes after nasal surgery and evaluate the *effect* of nasal surgery on PPs and [NPPs] , respectively . Regulation ENPP1 PSG4 23848264 2816897 The *effects* of nasal surgery on positional obstructive sleep apnea/hypopnea syndrome ( OSAHS ) patients ( PPs ) and [non-positional OSAHS patients (NPPs)] were different . Regulation ENPP1 PSG4 23848264 2816907 We aimed to determine the PSG data changes after nasal surgery and evaluate the *effect* of nasal surgery on PPs and [NPPs] , respectively . Regulation ENPP1 PSG5 23848264 2816898 The *effects* of nasal surgery on positional obstructive sleep apnea/hypopnea syndrome ( OSAHS ) patients ( PPs ) and [non-positional OSAHS patients (NPPs)] were different . Regulation ENPP1 PSG5 23848264 2816908 We aimed to determine the PSG data changes after nasal surgery and evaluate the *effect* of nasal surgery on PPs and [NPPs] , respectively . Regulation ENPP1 PSG6 23848264 2816899 The *effects* of nasal surgery on positional obstructive sleep apnea/hypopnea syndrome ( OSAHS ) patients ( PPs ) and [non-positional OSAHS patients (NPPs)] were different . Regulation ENPP1 PSG6 23848264 2816909 We aimed to determine the PSG data changes after nasal surgery and evaluate the *effect* of nasal surgery on PPs and [NPPs] , respectively . Regulation ENPP1 PSG7 23848264 2816900 The *effects* of nasal surgery on positional obstructive sleep apnea/hypopnea syndrome ( OSAHS ) patients ( PPs ) and [non-positional OSAHS patients (NPPs)] were different . Regulation ENPP1 PSG7 23848264 2816910 We aimed to determine the PSG data changes after nasal surgery and evaluate the *effect* of nasal surgery on PPs and [NPPs] , respectively . Regulation ENPP1 PSG8 23848264 2816901 The *effects* of nasal surgery on positional obstructive sleep apnea/hypopnea syndrome ( OSAHS ) patients ( PPs ) and [non-positional OSAHS patients (NPPs)] were different . Regulation ENPP1 PSG8 23848264 2816911 We aimed to determine the PSG data changes after nasal surgery and evaluate the *effect* of nasal surgery on PPs and [NPPs] , respectively . Regulation ENPP1 PSG9 23848264 2816902 The *effects* of nasal surgery on positional obstructive sleep apnea/hypopnea syndrome ( OSAHS ) patients ( PPs ) and [non-positional OSAHS patients (NPPs)] were different . Regulation ENPP1 PSG9 23848264 2816912 We aimed to determine the PSG data changes after nasal surgery and evaluate the *effect* of nasal surgery on PPs and [NPPs] , respectively . Regulation ENPP1 SERPINE1 22553514 2366937 The corresponding gene expression and function can affect POAG progress , including *roles* of in extracellular matrix , [ENPP1] in insulin inhibition , IL-6 in endogenous neuroprotection , IL-6 , IL-6R and E-Sel in autoimmune response , LIPC and FGB in blood hyperviscosity syndrome , ADIPOQ in NOS/NO production , PON1 in vascular endothelial protection . Regulation ENPP3 ALOX5 15388786 1359155 *Effects* of prostaglandin D ( 2 ) and <5-lipoxygenase> products on the expression of [CD203c] and CD11b by basophils . Regulation EP300 EPHB2 19489936 2120508 We show that ORF3 mediated activation was *responsible* for the observed increase in phosphorylation and transactivation activity of [p300/CBP] . Regulation EPB41 CD14 7561108 324194 Lipopolysaccharide stimulates the tyrosine phosphorylation of mitogen activated protein kinases p44 , p42 , and [p41] in vascular endothelial cells in a soluble *dependent* manner . Regulation EPC1 ID1 18092003 1838104 However , the manner in which loss in the BM *controls* [EPC] generation or mobilization is largely unknown . Regulation EPC1 ITGB2 16825578 1591420 Essential *role* of in mediating [EPC] recruitment , angiogenesis , and repair to the infarcted myocardium . Regulation EPC1 ITGB2 16825578 1591425 To further verify the functional *role* of in mediating [EPC] recruitment and repair to the infarcted myocardium , we used neutralizing antibody to block CD18 . Regulation EPC1 ITGB2 16825578 1591429 Thus , our results suggest an essential *role* of in mediating [EPC] recruitment and the subsequent functional effects on the infarcted heart . Regulation EPC1 TNF 17293363 1791615 Our data indicate that may be at least partly *responsible* for the reduction of [EPC] seen in patients with RA . Regulation EPC2 ID1 18092003 1838105 However , the manner in which loss in the BM *controls* [EPC] generation or mobilization is largely unknown . Regulation EPC2 ITGB2 16825578 1591422 Essential *role* of in mediating [EPC] recruitment , angiogenesis , and repair to the infarcted myocardium . Regulation EPC2 ITGB2 16825578 1591426 To further verify the functional *role* of in mediating [EPC] recruitment and repair to the infarcted myocardium , we used neutralizing antibody to block CD18 . Regulation EPC2 ITGB2 16825578 1591430 Thus , our results suggest an essential *role* of in mediating [EPC] recruitment and the subsequent functional effects on the infarcted heart . Regulation EPC2 TNF 17293363 1791616 Our data indicate that may be at least partly *responsible* for the reduction of [EPC] seen in patients with RA . Regulation EPHB1 EFNB1 20633976 2316728 Identification of expression in prostatic mesenchyme and a *role* for [EphB-EphrinB] signalling in prostate development . Regulation EPHB1 IL1B 16959849 1639709 Although there was no *effect* of on the phosphorylation of [ELK] , Janus kinase 2 , or signal transducers and activators of transcription ( STAT ) 1 , IL-1beta significantly increased tyrosine-phosphorylation of STAT3 , an effect attenuated by PD98059 . Regulation EPHB2 ABCC8 20051520 2211697 positively *regulates* [Ras/ERK] MAP kinase signaling by serving as a scaffold for Ras and Raf . Regulation EPHB2 ABL1 21715303 2471236 Using this vector in a murine syngeneic BM transplantation model for BCR-ABL induced chronic myeloid leukemia , we find that oncogene expression and target knockdown in primary hematopoietic cells with this vector is efficient both in vitro and in vivo , and demonstrate that Raf1 , but not BRAF , modulates *dependent* [ERK] activation and transformation of hematopoietic cells . Regulation EPHB2 ABL1 23462796 2776496 Imatinib stimulated [ERK] ( thr202/tyr204 ) phosphorylation in a *dependent* manner . Regulation EPHB2 ACD 20877310 2381765 Moreover , we found that negatively *regulated* GNDF induced [ERK] activation and neurite outgrowth . Regulation EPHB2 ACD 24523415 2924204 Moreover , our results showed that NMDA mediated activation of the small G-protein Ras is necessary for PI3K/Akt pathway activation , whereas was *involved* in NMDA phosphorylation of [ERK] . Regulation EPHB2 ACKR3 22083878 2540820 Moreover , mediated *effects* of SDF-1 on [Erk] and Akt signaling as well as on astrocytic proliferation and migration were all sensitive to pertussis toxin . Regulation EPHB2 ADAM8 19747075 2168248 These data suggest that the mitogenic *effect* of on fibroblasts is independent of its proteolytic activity , requires [ERK] phosphorylation , and involves activation of PLC . Regulation EPHB2 ADCY3 19070587 2018107 Furthermore , *dependent* inhibition of PDGF mediated [ERK-activation] and proliferation could be demonstrated . Regulation EPHB2 ADCYAP1 10940738 721090 Cyclic AMP increase is sufficient to elicit ERK activation in these cells and thus likely to represent the transduction pathway underlying VIP- and *dependent* [ERK] activation . Regulation EPHB2 ADCYAP1 12692897 1080612 The *effect* of on [ERK] phosphorylation was blocked by U0126 , but was not affected by H89 or chelerythrine indicating that PACAP activates ERK through a PKA- and PKC independent mechanism . Regulation EPHB2 ADM 12667639 1075621 Cotransfection of RAMP2 or RAMP3 with CRLR into rat VSMCs potentiated activation of cAMP activity , but not of p42/p44 [ERK/MAP] kinase activity in *response* to . Regulation EPHB2 ADO 19070587 2018108 Furthermore , a *dependent* inhibition of PDGF mediated [ERK-activation] and proliferation could be demonstrated . Regulation EPHB2 ADRBK1 10629859 576457 In contrast with H2O2 induced activation of ERK , the activation of [ERK] induced by phorbol ester PMA and the activation of JNK and p38 induced by H2O2 were not *affected* by expression of , indicating that the activation of ERK but not JNK and p38 is dependent on beta gamma subunit . Regulation EPHB2 ADRBK1 16077899 1442362 Western blotting assay shows that EGF induced ERK/MAPK phosphorylation increases 1.9-fold , 1.1-fold and 1.5-fold ( P < 0.05 ) at time point 30 , 60 and 120 min , respectively when the cells were transfected with GRK2 , suggesting the regulatory *role* of on EGF induced [ERK/MAPK] activation . Regulation EPHB2 AGAP2 23527545 2787933 The Arf GAP interacts with ß-arrestin2 and *regulates* ß2-adrenergic receptor recycling and [ERK] activation . Regulation EPHB2 AHR 24163404 2916344 Beta-naphthoflavone ( DB06732 ) mediates estrogen receptor positive breast cancer cell cycle arrest through *dependent* regulation of PI3K/AKT and [MAPK/ERK] signaling . Regulation EPHB2 AHR 24163404 2916379 Taken together , *dependent* inhibition of the PI3K/AKT pathway , activation of [MAPK/ERK] and modulation of ERa is a novel mechanism underlying BNF mediated antitumor effects in breast cancer , which may represent a promising strategy to be exploited in future clinical trials . Regulation EPHB2 AKT1 11592793 869714 Co-incubation with the reducing agent dithiothreitol or calcium chelators ( EDTA/EGTA ) inhibited partially or completely menadione 's effects on MEK/ERK and pathways , as well as menadione 's *effects* on PDGF induced [ERK] and Akt activations . Regulation EPHB2 AKT1 12468535 1055475 Negative *regulation* of [ERK] and Elk by modulates c-Fos transcription . Regulation EPHB2 AKT1 15337530 1291373 We have characterized the *role* of Drosophila PI3K and in [ERK] pathway activation involving insulin induced proliferation using Drosophila Schneider cells . Regulation EPHB2 AKT1 17408801 1736024 Changes in [ERK] phosphorylation in IRS-4 depleted cells were *independent* of ras/raf/MEK1/2- and . Regulation EPHB2 AKT1 19186178 2054114 Interestingly , activation of signaling had differential *effects* on [ERK] and p38 activation . Regulation EPHB2 AKT1 19243631 2044917 Inhibition of activity by PIA decreased NF-kappaB signaling , but did not *affect* phosphorylation of [ERK] , JNK , and p38 in KB and KOSCC-25B cells . Regulation EPHB2 AKT1 21939707 2511417 T2FA was able to inhibit the activation of GSK3ß , but not [ERK] , in an *dependent* manner . Regulation EPHB2 AKT1 23880664 2849564 Moreover , kisspeptin stimulated MAPKs and signaling , and [ERK] signaling was functionally *involved* in the kisspeptin induced GnRH expression . Regulation EPHB2 AKT1 24277456 2904546 Our results indicated that there was overactivation of in CDDP-resistant cells compared with sensitive cells , but no *effect* on activated [ERK] levels . Regulation EPHB2 AKT2 11592793 869715 Co-incubation with the reducing agent dithiothreitol or calcium chelators ( EDTA/EGTA ) inhibited partially or completely menadione 's effects on MEK/ERK and pathways , as well as menadione 's *effects* on PDGF induced [ERK] and Akt activations . Regulation EPHB2 AKT2 15337530 1291374 We have characterized the *role* of Drosophila PI3K and in [ERK] pathway activation involving insulin induced proliferation using Drosophila Schneider cells . Regulation EPHB2 AKT2 17408801 1736025 Changes in [ERK] phosphorylation in IRS-4 depleted cells were *independent* of ras/raf/MEK1/2- and . Regulation EPHB2 AKT2 19186178 2054115 Interestingly , activation of signaling had differential *effects* on [ERK] and p38 activation . Regulation EPHB2 AKT2 19243631 2044918 Inhibition of activity by PIA decreased NF-kappaB signaling , but did not *affect* phosphorylation of [ERK] , JNK , and p38 in KB and KOSCC-25B cells . Regulation EPHB2 AKT2 21939707 2511418 T2FA was able to inhibit the activation of GSK3ß , but not [ERK] , in an *dependent* manner . Regulation EPHB2 AKT2 23880664 2849565 Moreover , kisspeptin stimulated MAPKs and signaling , and [ERK] signaling was functionally *involved* in the kisspeptin induced GnRH expression . Regulation EPHB2 AKT2 24277456 2904547 Our results indicated that there was overactivation of in CDDP-resistant cells compared with sensitive cells , but no *effect* on activated [ERK] levels . Regulation EPHB2 AKT3 11592793 869716 Co-incubation with the reducing agent dithiothreitol or calcium chelators ( EDTA/EGTA ) inhibited partially or completely menadione 's effects on MEK/ERK and pathways , as well as menadione 's *effects* on PDGF induced [ERK] and Akt activations . Regulation EPHB2 AKT3 15337530 1291375 We have characterized the *role* of Drosophila PI3K and in [ERK] pathway activation involving insulin induced proliferation using Drosophila Schneider cells . Regulation EPHB2 AKT3 17408801 1736026 Changes in [ERK] phosphorylation in IRS-4 depleted cells were *independent* of ras/raf/MEK1/2- and . Regulation EPHB2 AKT3 19186178 2054116 Interestingly , activation of signaling had differential *effects* on [ERK] and p38 activation . Regulation EPHB2 AKT3 19243631 2044919 Inhibition of activity by PIA decreased NF-kappaB signaling , but did not *affect* phosphorylation of [ERK] , JNK , and p38 in KB and KOSCC-25B cells . Regulation EPHB2 AKT3 21939707 2511419 T2FA was able to inhibit the activation of GSK3ß , but not [ERK] , in an *dependent* manner . Regulation EPHB2 AKT3 23880664 2849566 Moreover , kisspeptin stimulated MAPKs and signaling , and [ERK] signaling was functionally *involved* in the kisspeptin induced GnRH expression . Regulation EPHB2 AKT3 24277456 2904548 Our results indicated that there was overactivation of in CDDP-resistant cells compared with sensitive cells , but no *effect* on activated [ERK] levels . Regulation EPHB2 ANGPT2 10406835 629632 In this study , we examined the role of extracellular signal regulated kinase ( ERK ) in Ang II-mediated TGF-beta(1) expression in VSMCs and the *role* of in aortic [ERK] activity of stroke-prone spontaneously hypertensive rats . Regulation EPHB2 ANGPT2 10891597 711266 The distinct *regulation* of [ERK] by and NGF further indicates basic differences in AT(2) receptor- and NGF induced neuronal differentiation . Regulation EPHB2 ANGPT2 11263267 764485 To investigate whether the *effect* of or epidermal growth factor (EGF) on cardiac fibroblast proliferation involved in activation of extracellular signal regulated kinase ( [ERK] ) 1/2 or Ca ( 2+ ) -calmodulin dependent protein kinase ( CCDPK ) mediated by protein kinase C (PKC)-zeta . Regulation EPHB2 ANGPT2 16554661 1574667 *dependent* [ERK] activation was inhibited by : ( 1 ) the type-1 ANG2-selective antagonist losartan ; Regulation EPHB2 ANGPT2 16554661 1574673 In contrast , had no *effect* on [ERK] phosphorylation in stably transfected HEK293 cells . Regulation EPHB2 ANGPT2 22781707 2645327 The *effect* of indoxyl sulfate and on phosphorylation of [ERK] and epidermal growth factor receptor (EGFR) , and migration were determined using VSMCs . Regulation EPHB2 ANXA1 22777765 2715527 *regulation* of [ERK] and NF-?B activation was associated with effects on proliferation . Regulation EPHB2 APC 16478791 1528393 The GTP loading and the protein level of mutated RAS were decreased in cells with reduced ERK activity as a result of APC overexpression , indicating that *regulates* RAS induced [ERK] activation at least partly by reduction of the RAS protein level . Regulation EPHB2 APC 17932312 1825548 Using siRNA , we found that the *effect* of on the [EGR-1/ERK] signaling required for TRAIL inhibition was dependent on the S1P1 receptor and S1P1 kinase . Regulation EPHB2 APOB 11118021 759452 Therefore , we examined the *effects* of on [ERK] phosphorylation in cultured rat mesangial cells . Regulation EPHB2 APOB 11509543 848324 Therefore , we examined the cellular *effects* of native and modified on [ERK] phosphorylation in VSMC . Regulation EPHB2 APOB 11509543 848328 Pretreatment of VSMC with a cell-permeable MEK inhibitor ( PD-98059 , 40 micromol/l ) significantly decreased [ERK] phosphorylation in *response* to native and modified . Regulation EPHB2 APOB 15750341 1379864 ERK phosphorylation was not affected by exposure to the Ca2+ chelator BAPTA-AM but inhibition of protein kinase C ( PKC ) with GF109203X , inhibition of Src kinase with PP1 ( 5 microM ) and inhibition of phospholipase C (PLC) with U73122/U73343 ( 5 microM ) all reduced [ERK] phosphorylation in *response* to glycated . Regulation EPHB2 APOB 15750341 1379866 In addition , pretreatment of the RASMCs with a cell-permeable mitogen activated protein kinase kinase ( MEK ) inhibitor ( PD98059 , 5 microM ) markedly decreased [ERK] phosphorylation in *response* to native and glycated . Regulation EPHB2 APOB 15750341 1379878 These findings indicate that [ERK] phosphorylation in *response* to glycated involves the activation of PKC , PLC , and MEK , but is independent of intracellular Ca2+ . Regulation EPHB2 APOB 22331607 2630243 Here , we investigated the *effects* of glycated and oxidized ( glc-oxLDL ) on [MAPK-ERK] and JNK signaling pathways using human coronary smooth muscle cells . Regulation EPHB2 APOE 23246654 2737163 While did not *affect* the activation of [ERK] , JNK , and p38 MAPK signaling pathways by RANKL , the phosphorylation of p65 trans-activation domain on serine 536 and transcription activity of NF-?B were reduced by ApoE overexpression . Regulation EPHB2 ARAF 15208680 1281419 B-RAF depletion by siRNA blocks ERK activity , whereas and C-RAF depletion do not *affect* [ERK] signalling . Regulation EPHB2 AREGB 20726858 2330327 *regulates* the activation of [ERK] and Akt through epidermal growth factor receptor and HER3 signals involved in the progression of pancreatic cancer . Regulation EPHB2 ARF6 16413265 1494798 To investigate the *role* of in tumor cell invasion and [ERK] activation , a number of methods were employed . Regulation EPHB2 ARF6 17363898 1720402 *dependent* activation of [ERK] and Rac1 modulates epithelial tubule development . Regulation EPHB2 ARHGEF7 19286672 2072938 A novel interaction between fibroblast growth factor receptor 3 and the p85 subunit of phosphoinositide 3-kinase : activation dependent *regulation* of [ERK] by in multiple myeloma cells . Regulation EPHB2 ARHGEF7 22305891 2575874 Tyrosines 303/343/353 within the Sprouty related domain of Spred2 are essential for its interaction with and inhibitory *effect* on [Ras/ERK] activation . Regulation EPHB2 ARRB1 17303558 1718941 This *dependent* [ERK] activity can occur even when the classical tyrosine kinase signaling is impaired . Regulation EPHB2 AXIN1 17374607 1734756 [ERK] pathway *regulation* by occurs at least partly via reduction of the protein level of Ras . Regulation EPHB2 AXIN2 17374607 1734757 [ERK] pathway *regulation* by occurs at least partly via reduction of the protein level of Ras . Regulation EPHB2 BCR 11027490 738984 We demonstrate that JNK and [ERK] activities are not *affected* by cross linking , suggesting that these MAPKs are not directly involved in initiating the apoptotic cascade . Regulation EPHB2 BCR 15569688 1368320 With respect to MAPK activation , HSH2 was not observed to alter the activation of [ERK] or p38 in *response* to ligation , but it does significantly potentiate JNK activation . Regulation EPHB2 BCR 16585562 1544195 Intracellular calcium signaling and [ERK] activation in *response* to engagement were also proportionately decreased and delayed , respectively , with stepwise reduction of plcgamma2 dosage in a BLNK ( null ) background . Regulation EPHB2 BCR 16809760 1580478 B-cell proliferation , cell cycle progression , PLC-gamma2 phosphorylation , calcium mobilization , NF-ATp dephosphorylation , and [Erk] and Jnk activation in *response* to ligation were all impaired . Regulation EPHB2 BCR 21715303 2471235 Using this vector in a murine syngeneic BM transplantation model for BCR-ABL induced chronic myeloid leukemia , we find that oncogene expression and target knockdown in primary hematopoietic cells with this vector is efficient both in vitro and in vivo , and demonstrate that Raf1 , but not BRAF , modulates *dependent* [ERK] activation and transformation of hematopoietic cells . Regulation EPHB2 BCR 24958853 2947351 Our findings indicate that in immature B cells , basal activation of Ras and [Erk] are *controlled* by tonic signaling , and that positive changes in Ras activity can lead to a break in both central and peripheral B-cell tolerance . Regulation EPHB2 BCR 24989471 2948158 Here , we indicate that the ZIP9 induces increase in intracellular zinc level and plays an important role in the phosphorylation of Akt and [Erk] in *response* to activation . Regulation EPHB2 BDNF 14572451 1155788 signaling via TrkB receptors but not SP signaling via NK(1) were also *involved* in [ERK] recruitment . Regulation EPHB2 BDNF 17532077 1778386 These results suggest *roles* of in the DRG induced [ERK] activation in the embryonic dorsal horn . Regulation EPHB2 BMP1 21846488 2521788 Thus , the difference between BMP-6 and BMP-7 in enhancing GnRH induced FSHß transcription may be due to the differential *effects* of ligands on GnRH induced [ERK] signaling . Regulation EPHB2 BMP10 21846488 2521796 Thus , the difference between BMP-6 and BMP-7 in enhancing GnRH induced FSHß transcription may be due to the differential *effects* of ligands on GnRH induced [ERK] signaling . Regulation EPHB2 BMP15 21846488 2521789 Thus , the difference between BMP-6 and BMP-7 in enhancing GnRH induced FSHß transcription may be due to the differential *effects* of ligands on GnRH induced [ERK] signaling . Regulation EPHB2 BMP2 21846488 2521790 Thus , the difference between BMP-6 and BMP-7 in enhancing GnRH induced FSHß transcription may be due to the differential *effects* of ligands on GnRH induced [ERK] signaling . Regulation EPHB2 BMP3 21846488 2521791 Thus , the difference between BMP-6 and BMP-7 in enhancing GnRH induced FSHß transcription may be due to the differential *effects* of ligands on GnRH induced [ERK] signaling . Regulation EPHB2 BMP4 21846488 2521792 Thus , the difference between BMP-6 and BMP-7 in enhancing GnRH induced FSHß transcription may be due to the differential *effects* of ligands on GnRH induced [ERK] signaling . Regulation EPHB2 BMP5 21846488 2521793 Thus , the difference between BMP-6 and BMP-7 in enhancing GnRH induced FSHß transcription may be due to the differential *effects* of ligands on GnRH induced [ERK] signaling . Regulation EPHB2 BMP6 21846488 2521794 Thus , the difference between BMP-6 and BMP-7 in enhancing GnRH induced FSHß transcription may be due to the differential *effects* of ligands on GnRH induced [ERK] signaling . Regulation EPHB2 BMP7 21846488 2521795 Thus , the difference between BMP-6 and BMP-7 in enhancing GnRH induced FSHß transcription may be due to the differential *effects* of ligands on GnRH induced [ERK] signaling . Regulation EPHB2 BRAF 16342120 1504042 Our findings demonstrate that *plays* a role in hippocampal [ERK] activation , synaptic plasticity , and L & M . Regulation EPHB2 BRAF 16432225 1521555 Essential *role* of in [ERK] activation during extraembryonic development . Regulation EPHB2 BRAF 16432225 1521556 The data demonstrate that *plays* a nonredundant role in [ERK] activation during extraembyronic mammalian development in vivo . Regulation EPHB2 BRAF 19638574 2118598 We have now examined the *effects* of sorafenib as well as of or C-RAF depletion by RNA interference on cell growth and [ERK] signaling in non-small cell lung cancer ( NSCLC ) cell lines with or without KRAS mutations . Regulation EPHB2 BRCC3 17143545 1668120 These findings demonstrate that BRCC3 is a novel effector of Raf-1 , and implicate a *role* of in modulation of [p-ERK] , cell survival and proliferation . Regulation EPHB2 BTRC 19956885 2184991 Using c-kit positive SCLC cells ( H209 and H69 cells ) and SCF as a model of the autocrine mechanisms , the *effects* of , LY294002 , PD98059 or STI571 on Akt and [Erk] were assessed by Western blot analysis . Regulation EPHB2 BTRC 21330471 2415117 Half the population phosphorylated [Erk] in *response* to between 0.9 and 1.2 minutes , and S6 phosphorylation followed approximately a minute later ( t & frac12 ; ( pS6 rise ) = 2.2-2.7 minutes ) . Regulation EPHB2 C1QA 16908670 1601628 We show that ERK signaling is required for phagocytosis of apoptotic cells and that [ERK] phosphorylation in *response* to apoptotic cells or is defective in ABCA7-deficient cells . Regulation EPHB2 C1QB 16908670 1601629 We show that ERK signaling is required for phagocytosis of apoptotic cells and that [ERK] phosphorylation in *response* to apoptotic cells or is defective in ABCA7-deficient cells . Regulation EPHB2 C5 14984438 1214686 Time dependent *effect* of on p44/p42 phosphorylation was rapid , peaked at 5 min , and was abrogated by the [ERK] inhibitor ( P=0.04 ) . Regulation EPHB2 CA2 10051431 593076 We have examined the *involvement* of and protein kinase C ( PKC ) in [ERK] and JNK activation by the human G-protein coupled m2 and m3 muscarinic acetylcholine receptors ( mAChR ) expressed in Chinese hamster ovary ( CHO ) cells . Regulation EPHB2 CA2 11914123 984257 The present data indicate that is *involved* in [ERK] activation induced by hormones acting on G protein coupled receptors in hepatocytes , and suggest that calmodulin and Src kinases might play a role in these signaling pathways . Regulation EPHB2 CA2 14519666 1147829 IL-1 induced release of from internal stores is dependent on cell-matrix interactions and *regulates* [ERK] activation . Regulation EPHB2 CA2 15750341 1379876 These findings indicate that [ERK] phosphorylation in response to glycated LDL involves the activation of PKC , PLC , and MEK , but is *independent* of intracellular . Regulation EPHB2 CA2 15781976 1352644 Interestingly , acute application of Abeta or APP overexpression inhibits activity dependent regulation of several protein kinase pathways that require Ca2+ influx via NMDA receptors for activation , including *dependent* protein kinase II , protein kinase A , and [extracellular regulated kinases (Erk)] . Regulation EPHB2 CA2 15890671 1445579 In the present studies , we examined the hypothesis that calmodulin (Cam) plays a fundamental role in mediating the *effects* of on [ERK] activation . Regulation EPHB2 CA2 16024629 1435269 Selective inhibition of EP receptors revealed the possible *involvement* of dependent signaling in PGE2 mediated activation of [Erk] . Regulation EPHB2 CA2 18573569 1946494 IgIII ( 270-280 ) -fragment-like H2N-DDSDEEN-COOH peptide modulates N-CAM expression via *dependent* [ERK] signaling during `` in vitro neurogenesis '' . Regulation EPHB2 CA2 8855261 388181 To investigate whether the *dependent* activation of mitogen activated protein kinases ( [ERK] , JNK , and p38 ) might be mediated by the CaM kinase cascade , we have transfected PC12 cells , which lack CaM-KIV , with constitutively active mutants of CaM kinase kinase and/or CaM-KIV ( CaM-KKc and CaM-KIVc , respectively ) . Regulation EPHB2 CALB1 15040837 1224382 The anti-apoptotic *effect* of involves inhibition of glucocorticoid induced caspase 3 activation as well as [ERK] activation . Regulation EPHB2 CALM3 10648884 662341 This finding indicates that the *dependent* activation of [ERK] and p38 kinase is involved in calcium induced c-fos expression . Regulation EPHB2 CALM3 10718374 676662 Interactions of *dependent* protein kinases ( CaMK ) and [extracellular regulated kinase (ERK)] in monocyte adherence and TNFalpha production . Regulation EPHB2 CALM3 11457825 850812 mu-Opioid receptor mediated [ERK] activation *involves* dependent epidermal growth factor receptor transactivation . Regulation EPHB2 CALM3 15781976 1352645 Interestingly , acute application of Abeta or APP overexpression inhibits activity dependent regulation of several protein kinase pathways that require Ca2+ influx via NMDA receptors for activation , including *dependent* protein kinase II , protein kinase A , and [extracellular regulated kinases (Erk)] . Regulation EPHB2 CALM3 19800889 2184026 From these results , it is suggested that PTTH stimulated [ERK] phosphorylation is only partially Ca ( 2+ ) - and *dependent* and that HNMPA- ( AM ) ( 3 ) -sensitive receptor tyrosine kinase is involved in activation of ERK phosphorylation by PTTH . Regulation EPHB2 CALM3 22904641 2647462 Inhibitor studies suggest that BK-induced [ERK] activation requires phospholipase C and protein kinase C activities , and is Ca ( 2+ ) *dependent* . Regulation EPHB2 CASC3 21176351 2358236 The study was aimed to investigate the *effects* of on the expression of [ERK] , JNK and P38 in daunorubicin ( DNR ) -resistant K562 cells ( K562/DNR ) and to clarify the molecular mechanism of BTZ in reversing the drug-resistance in leukemic cells . Regulation EPHB2 CASP1 12807432 1101980 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Regulation EPHB2 CASP10 12807432 1101981 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Regulation EPHB2 CASP12 12807432 1101991 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Regulation EPHB2 CASP14 12807432 1101982 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Regulation EPHB2 CASP16 12807432 1101992 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Regulation EPHB2 CASP2 12807432 1101983 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Regulation EPHB2 CASP3 12807432 1101984 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Regulation EPHB2 CASP4 12807432 1101985 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Regulation EPHB2 CASP5 12807432 1101986 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Regulation EPHB2 CASP6 12807432 1101987 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Regulation EPHB2 CASP7 12807432 1101988 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Regulation EPHB2 CASP8 12807432 1101989 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Regulation EPHB2 CASP9 12807432 1101990 Remarkably , *dependent* cleavage of NF-kappaB family members as well as of Akt and CREB proteins , but not of [ERK] , became prominent at 24 h , a time point coincident with the peak of caspase dependent apoptosis . Regulation EPHB2 CAT 12682429 1077799 However , exogenously added SOD1 and heat inactivated had no *effect* on either toxicity or sustained [ERK] phosphorylation . Regulation EPHB2 CAT 17384286 1665313 Deferoxamine ( DFO ; iron chelator ) , ( hydrogen peroxide removing enzyme ) , or alpha-tocopherol ( peroxyl-radical scavenger ) did not *affect* DOX increased [ERK] phosphorylation levels . Regulation EPHB2 CAT 23613809 2774673 Furthermore , we found that the presence of NAC , as well as the overexpression of MnSOD , could almost completely abolish the activation of Akt , extracellular-signal regulated kinase ( [Erk] ) 1/2 , c-Jun N-terminal kinase (JNK) , and p38 , although only JNK and p38 were *affected* by overexpression of . Regulation EPHB2 CAV1 15072971 1232659 We suggest that stretch induced translocation of to noncaveolar sites *plays* an important role in mediating stretch induced [ERK] activation in VSMCs . Regulation EPHB2 CAV1 16676355 1624560 However in contrast to adipocytes , phosphorylation of insulin receptor beta (IRbeta) and [Akt/Erk] was not *affected* by the respective downregulation of or caveolin-3 in the muscle cells . Regulation EPHB2 CAV1 19288272 2185413 Recombinant expression of in TAM-R cells did not *affect* [EGFR/ERK] activity , potentially due to mislocalisation of caveolin-1 through hyperactivation of the mTOR pathway or altered caveolin-1 phosphorylation . Regulation EPHB2 CAV1 19499152 2091874 Our study showed the interaction of IFITM1- and CAV-1 enhanced 's inhibitory *effect* on [ERK] activation , whereas the IFITM1 did not activate ERK directly . Regulation EPHB2 CAV1 19499152 2091879 These results revealed that the interaction between IFITM1 and CAV-1 could enhance the inhibitory *effect* of on [ERK] activation . Regulation EPHB2 CAV1 22230296 2569223 Estrogen- and xenoestrogen induced [ERK] signaling in pituitary tumor cells *involves* estrogen receptor-a interactions with G protein-ai and . Regulation EPHB2 CAV1 22366257 2566022 On the basis of our previous study demonstrating a physical interaction between the Ca(V)1 .3 channel and GABA(B) receptor ( GABA ( B ) R ) , we further examined the *involvement* of .2 and Ca(V)1 .3 in the GABA ( B ) R-mediated activation of [ERK] ( 1/2 ) , a kinase involved in both CREB activation and synaptic plasticity . Regulation EPHB2 CAV2 15072971 1232660 We suggest that stretch induced translocation of to noncaveolar sites *plays* an important role in mediating stretch induced [ERK] activation in VSMCs . Regulation EPHB2 CAV3 15072971 1232661 We suggest that stretch induced translocation of to noncaveolar sites *plays* an important role in mediating stretch induced [ERK] activation in VSMCs . Regulation EPHB2 CAV3 16676355 1624561 However in contrast to adipocytes , phosphorylation of insulin receptor beta (IRbeta) and [Akt/Erk] was not *affected* by the respective downregulation of caveolin-1 or in the muscle cells . Regulation EPHB2 CCDC88A 23370007 2747789 Here , we explore whether and reactive oxygen species ( ROS ) *affect* [ERK] signaling and cell cycle progression following Pb exposure . Regulation EPHB2 CCL21 21698152 2446734 LY294002 , a selective inhibitor of PI3K that prevents activation of the downstream Akt , did not weaken the *effect* of on [P-ERK] . Regulation EPHB2 CCND1 12359725 1018973 Taken together , these data show a new role for ERK in G1 cell cycle progression : In addition to its role in stimulating expression and nuclear translocation of CDK2 , [ERK] *regulates* Thr-160 phosphorylation of CDK2-cyclin E . Regulation EPHB2 CCND1 15033934 1237365 Taken together , our findings define a critical role for SAMe in [ERK] signaling and *regulation* during regeneration and suggest chronic hepatic SAMe depletion results in loss of responsiveness to mitogenic signals . Regulation EPHB2 CCND1 16368887 1539739 We therefore conclude not only that is a target of the Tal1/Sp1 complex , but also that Notch3 dependent activation of [pre-TCR/ERK] signaling *regulates* SCL/Tal1 function . Regulation EPHB2 CCND1 24342356 2917001 Further studies showed that SUMOylation at Lys-138 was critical for RhoGDIa down-regulation of protein expression and that [MEK1/2-Erk] was a specific downstream *target* of SUMOylated RhoGDIa for its inhibition of C-Jun/AP-1 cascade , cyclin d1 transcription , and cell cycle progression . Regulation EPHB2 CCR7 21698152 2446735 LY294002 , a selective inhibitor of PI3K that prevents activation of the downstream Akt , did not weaken the *effect* of on [P-ERK] . Regulation EPHB2 CCR7 23449735 2787370 Finally , primed eosinophils stimulated with CCL19 or CCL21 exhibited increased phosphorylation of [ERK] in *response* to both ligands . Regulation EPHB2 CD14 16879219 1593875 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by [MEK/ERK] signaling and NFkappaB activation and that membrane bound and TLR-4 are *involved* in this mechanism . Regulation EPHB2 CD24 22369943 2572341 Furthermore , phosphorylation of [ERK] by EGF stimulation was significantly *affected* by the expression of CD26 , but not . Regulation EPHB2 CD3D 14680820 1179157 Unexpectedly , dominant negative Ras17N blocked activation of Ras and [ERK] in *response* to IL-2R engagement but not ligation . Regulation EPHB2 CD3E 14680820 1179158 Unexpectedly , dominant negative Ras17N blocked activation of Ras and [ERK] in *response* to IL-2R engagement but not ligation . Regulation EPHB2 CD3G 14680820 1179159 Unexpectedly , dominant negative Ras17N blocked activation of Ras and [ERK] in *response* to IL-2R engagement but not ligation . Regulation EPHB2 CD40 16585179 1544131 In contrast , CD40-resistant lines showed no constitutive activation of ERK and no increase in [ERK] activity in *response* to stimulation . Regulation EPHB2 CD40 22711886 2621440 Moreover , consistent with previous results , we also show that TRAF2 was required for efficient JNK and [ERK] activation in *response* to engagement . Regulation EPHB2 CD40 9498749 490594 Finally , agents that elevate cAMP , causing protein kinase A-mediated inhibition of Raf-1 , inhibited activation of ERK in response to mIg cross linking , but had no affect on [ERK] activation in *response* to or Jun N-terminal kinase activation by signals through either receptor . Regulation EPHB2 CD44 16565089 1555778 Taken together , our findings suggest that interaction with LARG and EGFR *plays* a pivotal role in Rho/Ras co-activation , PLC epsilon-Ca2+ signaling , and [Raf/ERK] up-regulation required for CaMKII mediated cytoskeleton function and in head and neck squamous cell carcinoma progression . Regulation EPHB2 CD44 20956971 2389486 The results raise the novel idea that the EGFR may activate [Raf-MEK-ERK] signaling in *response* to the binding of HA to . Regulation EPHB2 CD79A 11027490 738985 We demonstrate that JNK and [ERK] activities are not *affected* by cross linking , suggesting that these MAPKs are not directly involved in initiating the apoptotic cascade . Regulation EPHB2 CD79A 15569688 1368321 With respect to MAPK activation , HSH2 was not observed to alter the activation of [ERK] or p38 in *response* to ligation , but it does significantly potentiate JNK activation . Regulation EPHB2 CD79A 16585562 1544196 Intracellular calcium signaling and [ERK] activation in *response* to engagement were also proportionately decreased and delayed , respectively , with stepwise reduction of plcgamma2 dosage in a BLNK ( null ) background . Regulation EPHB2 CD79A 22951891 2701739 Moreover , *dependent* [ERK] activation required renin-angiotensin system as its blockade was efficient in reducing proteinuria in those patients exhibiting substantial mesangial activation of ERK . Regulation EPHB2 CD79A 24958853 2947352 Our findings indicate that in immature B cells , basal activation of Ras and [Erk] are *controlled* by tonic signaling , and that positive changes in Ras activity can lead to a break in both central and peripheral B-cell tolerance . Regulation EPHB2 CD79A 24989471 2948159 Here , we indicate that the ZIP9 induces increase in intracellular zinc level and plays an important role in the phosphorylation of Akt and [Erk] in *response* to activation . Regulation EPHB2 CD79B 11027490 738986 We demonstrate that JNK and [ERK] activities are not *affected* by cross linking , suggesting that these MAPKs are not directly involved in initiating the apoptotic cascade . Regulation EPHB2 CD79B 15569688 1368322 With respect to MAPK activation , HSH2 was not observed to alter the activation of [ERK] or p38 in *response* to ligation , but it does significantly potentiate JNK activation . Regulation EPHB2 CD79B 16585562 1544197 Intracellular calcium signaling and [ERK] activation in *response* to engagement were also proportionately decreased and delayed , respectively , with stepwise reduction of plcgamma2 dosage in a BLNK ( null ) background . Regulation EPHB2 CD79B 24958853 2947353 Our findings indicate that in immature B cells , basal activation of Ras and [Erk] are *controlled* by tonic signaling , and that positive changes in Ras activity can lead to a break in both central and peripheral B-cell tolerance . Regulation EPHB2 CD79B 24989471 2948160 Here , we indicate that the ZIP9 induces increase in intracellular zinc level and plays an important role in the phosphorylation of Akt and [Erk] in *response* to activation . Regulation EPHB2 CD8A 20595932 2303428 Examination of ERK phosphorylation in high and low MHC-I expressing effectors revealed marked differences , suggesting that the interaction between on the veto CTL , and MHC-I on the effector cells is likely *responsible* for [ERK] phosphorylation . Regulation EPHB2 CD8B 20595932 2303429 Examination of ERK phosphorylation in high and low MHC-I expressing effectors revealed marked differences , suggesting that the interaction between on the veto CTL , and MHC-I on the effector cells is likely *responsible* for [ERK] phosphorylation . Regulation EPHB2 CDC42 12511425 1070849 We conclude from these data that *dependent* activation of [MAPK/ERK] is a critical event in the immediate phagocytic response of PMNs to microbial challenge . Regulation EPHB2 CDH1 18318220 1840099 Study of signal transduction mediated by EGF and HGF in cells with different state of cell adhesion demonstrated that could *affect* [ERK-signal-duration] . Regulation EPHB2 CDH2 17785185 1790523 *regulates* cytoskeletally associated [IQGAP1/ERK] signaling and memory formation . Regulation EPHB2 CDK2 12359725 1018974 Taken together , these data show a new role for ERK in G1 cell cycle progression : In addition to its role in stimulating cyclin D1 expression and nuclear translocation of , [ERK] *regulates* Thr-160 phosphorylation of CDK2-cyclin E . Regulation EPHB2 CDKN1A 24823378 2937664 Here , we show that the protein kinase [Erk] , which plays a central role in a number of key developmental processes in vertebrates , is *regulated* in the developing neural crest by . Regulation EPHB2 CFLAR 14578361 1186868 Furthermore , introduction of PTEN back into Jurkat cells eliminated the stimulatory *effect* of on IL-2 production and [ERK] activation . Regulation EPHB2 CGA 15817663 1417625 However , little is known about the *effects* of on [ERK] activity in theca cells . Regulation EPHB2 CGB8 15817663 1417624 However , little is known about the *effects* of on [ERK] activity in theca cells . Regulation EPHB2 CISH 9484843 488186 We have here examined the *effect* of and trans-DDP on the activation of [ERK] and JNK activities . Regulation EPHB2 CNR1 15886210 1433048 Using CB1/2-/- murine embryonic fibroblasts , we present the first direct evidence that both are *involved* in 2-AG induced [ERK] activation . Regulation EPHB2 CNR1 21914493 2506743 *regulates* [ERK] and GSK-3ß dependent glucocorticoid inhibition of osteoblast differentiation in murine MC3T3-E1 cells . Regulation EPHB2 CNR1 21914493 2506751 signaling *regulated* JNK , [ERK] , GSK-3ß , and Akt activation as well as Runx2 and IGF-I expression . Regulation EPHB2 CNR2 15886210 1433045 Whether is *involved* in 2-AG induced [ERK] activation is still unclear . Regulation EPHB2 CPD 15672448 1409538 In EGFR-devoid NR6 fibroblasts and MEK ( ERK kinase ) mutated MCF7 cells , Cpd 5 treatment also resulted in ERK phosphorylation , providing support for the idea that 5 can directly *act* on [ERK] phosphorylation by inhibiting Cdc25A activity . Regulation EPHB2 CPT2 12402047 1009412 However , both in cell lines in which cAMP inhibits growth-factor induced ERK activation and in which cAMP activates ERK , <8CPT-2Me-cAMP> did not *affect* [ERK] activity . Regulation EPHB2 CREB1 21403841 2404532 In this respect , the inhibition of [ERK] phosphorylation reduces AR expression and mediated transcriptional regulation of AR *acts* as a downstream connector between the AR and ERK signaling pathways in molecular apocrine cells . Regulation EPHB2 CRK 12112010 963588 Thus , we speculate that during inflammatory conditions in vivo macrophage may *regulate* JNK and [ERK] activity and inhibit IL-10 expression . Regulation EPHB2 CRK 12475948 1023726 We especially focused on the *role* of adaptor protein in [EphB] mediated signaling . Regulation EPHB2 CRK 15833106 1403935 By means of specific inhibitors we showed that and ERK act downstream of CD28 and that [ERK] and JNK *act* downstream of ICOS leading to the induction of various T cell derived cytokines . Regulation EPHB2 CRK 18796294 1976168 In addition , TNFalpha induced p53 activation was reduced by [ERK] or JNK inhibition , but it was not *affected* by inhibition . Regulation EPHB2 CRK 19456864 2115459 We also show that *affects* [ERK] via secreted IL-10 ( autocrine crosstalk ) . Regulation EPHB2 CRK 21251657 2397977 The *role* of TGF-ß1 activated in inhibiting phosphorylation of [ERK] was evaluated by treating samples with SB203580 , an inhibitor of p38 activation . Regulation EPHB2 CSE 24610934 2933906 *effects* on Drp1 vs . Mfn2 and mitochondrial network morphology involved reactive oxygen species ( ROS ) , activation of extracellular signal regulated kinase ( [ERK] ) , phosphatidylinositol 3-kinase (PI3K)/protein kinase B ( Akt ) , protein kinase C ( PKC ) and proteasome pathways , as well as transcriptional regulation via factors such as NF-?B and nuclear erythroid 2-related factor 2 . Regulation EPHB2 CSF1 14579277 1156776 These isomerase inhibitors exerted a negative effect on a key element involved in macrophage proliferation , namely the *dependent* activation of the extracellular signal regulated kinases ( [ERK] ) . Regulation EPHB2 CSF1 16709817 1564304 However , whereas [ERK] phosphorylation in *response* to is Raf-1 dependent , in response to LPS , an alternative pathway directs the activation of these kinases . Regulation EPHB2 CSF1 22028782 2499269 Our results demonstrated that *dependent* [Erk] activation and proliferation are regulated differentially in progenitors and differentiated cells . Regulation EPHB2 CSF2 19179468 2061196 Ptpn11 ( D61Y ) common myeloid progenitors ( CMPs ) and granulocyte-monocyte progenitors (GMPs) produce cytokine independent colonies in a cell-autonomous manner and demonstrate elevated [Erk] and Stat5 activation in *response* to granulocyte-macrophage ( GM-CSF ) stimulation . Regulation EPHB2 CSF2 20064484 2212101 G-CSF and did not *affect* TLR agonist induced phosphorylation of [ERK] , p38 , JNK , Akt , and IkappaBalpha . Regulation EPHB2 CSF3 14736711 1242685 did not *affect* LPS induced activation of [ERK] , p38 , JNK , and NF-kappa B , indicating that G-CSF affects the pathway downstream or independently of these signaling molecules . Regulation EPHB2 CSF3 20064484 2212102 and GM-CSF did not *affect* TLR agonist induced phosphorylation of [ERK] , p38 , JNK , Akt , and IkappaBalpha . Regulation EPHB2 CSK 14967142 1209098 Shp2 *regulates* SRC family kinase activity and [Ras/Erk] activation by controlling recruitment . Regulation EPHB2 CSK 9486662 488360 Overexpression of or the dominant negative mutant of Ras had no *effects* on Ang II-induced [ERK] activation in cardiac myocytes . Regulation EPHB2 CUL1 19956885 2184992 Using c-kit positive SCLC cells ( H209 and H69 cells ) and SCF as a model of the autocrine mechanisms , the *effects* of , LY294002 , PD98059 or STI571 on Akt and [Erk] were assessed by Western blot analysis . Regulation EPHB2 CUL1 21330471 2415118 Half the population phosphorylated [Erk] in *response* to between 0.9 and 1.2 minutes , and S6 phosphorylation followed approximately a minute later ( t & frac12 ; ( pS6 rise ) = 2.2-2.7 minutes ) . Regulation EPHB2 CXCL12 22083878 2540819 Moreover , CXCR7 mediated *effects* of on [Erk] and Akt signaling as well as on astrocytic proliferation and migration were all sensitive to pertussis toxin . Regulation EPHB2 CXCL12 22845908 2635806 Conditioned media from Ltv-p53 transferred SMCs activated PI3K/Akt/mTOR and [MAPK/Erk] signaling in a *dependent* manner and thereby promoted mesenchymal stem cell (MSC) migration and proliferation . Regulation EPHB2 CXCL9 9498749 490595 Finally , agents that elevate cAMP , causing protein kinase A-mediated inhibition of Raf-1 , inhibited activation of [ERK] in *response* to cross linking , but had no affect on ERK activation in response to anti-CD40 or Jun N-terminal kinase activation by signals through either receptor . Regulation EPHB2 CXCR3 15613278 1357414 The *role* of a receptor in [Erk] phosphorylation was substantiated by the ability of CXCL11 , another potent CXCR3 ligand , to induce Erk phosphorylation in the NUB6 and SK-NMC cells . Regulation EPHB2 DCN 11567999 864116 Furthermore , increases macrophage adhesion to the extracellular matrix , and this may be partially *responsible* for the expression of p27 ( Kip1 ) and the modification of [ERK] activity , but not for the increased cell survival . Regulation EPHB2 DEDD 11965497 932800 are *involved* in important cellular processes such as death-receptor induced apoptosis , NF-kappaB activation and [ERK] activation . Regulation EPHB2 DKK1 17374561 1748333 WNT3a induced [ERK] pathway activation was not *affected* by , although WNT3a induced activations of the WNT/beta-catenin pathway and proliferation were reduced by DKK-1 . Regulation EPHB2 DMP1 21401930 2404504 In Drosophila , , that encodes an ERK scaffold protein , *regulates* [ERK] signaling during wing development and contributes to intervein and vein cell differentiation . Regulation EPHB2 DPP4 22369943 2572342 Furthermore , phosphorylation of [ERK] by EGF stimulation was significantly *affected* by the expression of , but not CD24 . Regulation EPHB2 DRD1 18614186 1936152 Delayed , context- and *dependent* activation of [ERK] in morphine sensitized mice . Regulation EPHB2 DUSP1 14608042 1162193 The mutant did not *affect* [ERK] activity , indicating that MKP-1 preferentially down-regulates SAPK/JNK in C3H10T 1/2 cells . Regulation EPHB2 DUSP1 15096509 1258231 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP1 17761948 1822762 *Regulation* of [ERK] by provides a novel mechanism for control of osteoblast proliferation by GCs . Regulation EPHB2 DUSP1 18786515 2008951 The increase of and Dusp5 mRNAs is not *controlled* by [ERK] activation while that of Dusp14 is a direct negative-feedback mechanism of MDMA induced ERK signalling . Regulation EPHB2 DUSP1 19476641 2102352 We found that the selective inhibition of by Ro-31-8220 and PSI2106 , did not *affect* [p-ERK] expression in LPS+JWH015 treated microglia . Regulation EPHB2 DUSP1 24253595 2910518 Thus , [MEK/ERK] activity *controls* the levels of and , thereby , regulates JNK activity in polyamine depleted cells . Regulation EPHB2 DUSP1 9013447 411637 This study suggests a potential mechanism to *regulate* [ERK] activity through feedback inhibition by demonstrating the ERK cascade 's induction of the dual-specificity PTPases , PAC1 , and B23 . Regulation EPHB2 DUSP10 15096509 1258232 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP10 16181551 1461990 Both SHP2 and *play* some roles in P2Y receptor mediated activation of [MEK/ERK] , p38 signaling pathways and prostate cancer invasion . Regulation EPHB2 DUSP11 15096509 1258233 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP12 15096509 1258234 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP13 15096509 1258226 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP14 15096509 1258222 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP15 15096509 1258221 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP16 15096509 1258223 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP18 15096509 1258224 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP19 15096509 1258225 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP2 15096509 1258235 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP21 15096509 1258227 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP22 15096509 1258220 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP23 15096509 1258228 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP26 15096509 1258230 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP26 16581800 1543959 While activated ERK phosphorylates Hsf4b , *controls* the activity of [ERK] , leading to phosphorylation/dephosphorylation of Hsf4b , altering its ability to bind DNA . Regulation EPHB2 DUSP27 15096509 1258229 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP28 15096509 1258243 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP3 15096509 1258236 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP3 16845380 1592254 Our findings show that direct interaction of with VRK3 posttranslationally *regulates* [ERK] signalling . Regulation EPHB2 DUSP3 18035061 1852160 Our results suggest that in addition to neuronal cells , various other rodent adult tissues and embryos possess a common signaling mechanism which is involved in an indirect *regulation* of [ERK] activity by VRK3 mediated activity . Regulation EPHB2 DUSP4 15096509 1258237 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP5 15096509 1258238 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP5 18786515 2008952 The increase of Dusp1 and mRNAs is not *controlled* by [ERK] activation while that of Dusp14 is a direct negative-feedback mechanism of MDMA induced ERK signalling . Regulation EPHB2 DUSP5 20806045 2313865 and DUSP6 selectively *control* [ERK] pathway activity and proliferation . Regulation EPHB2 DUSP5 23720316 2796833 Signal dependent repression of by class I HDACs *controls* nuclear [ERK] activity and cardiomyocyte hypertrophy . Regulation EPHB2 DUSP6 14701731 1196028 However , the physiological roles of MKP-3 and the mechanism by which *regulates* Ras/Drosophila [ERK] ( DERK ) signaling in vivo have not been determined . Regulation EPHB2 DUSP6 15096509 1258239 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP6 20806045 2313866 DUSP5 and selectively *control* [ERK] pathway activity and proliferation . Regulation EPHB2 DUSP6 21680106 2451358 These results indicate that acts as a negative feedback regulator of ERK in adenocarcinoma progression , but that DUSP6 does not *play* a role in the downregulation of [ERK] in squamous cell carcinoma . Regulation EPHB2 DUSP6 22155192 2563142 The genetic association of with bipolar disorder and its *effect* on [ERK] activity . Regulation EPHB2 DUSP7 15096509 1258240 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP8 15096509 1258241 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DUSP9 15096509 1258242 This is the first example of a viral protein *regulating* [ERK] activation by inhibition of its cognate . Regulation EPHB2 DYRK1A 22923366 2719829 , a serine/threonine kinase , is *involved* in [ERK] and Akt activation in the brain of hyperhomocysteinemic mice . Regulation EPHB2 DYRK1A 22923366 2719833 This increase was abolished when CBS-deficient and Dyrk1A-transgenic mice were treated with harmine , an inhibitor of Dyrk1A kinase activity , which emphasizes the *role* of activity on [ERK] and Akt activation . Regulation EPHB2 E2F1 18396012 1899399 [ERK] activation is *regulated* by and is essential for E2F1 induced S phase entry . Regulation EPHB2 E2F1 18396012 1899400 We identify here a novel link between E2F1 and the Ras/Raf/MEK/ERK signaling pathway , namely that levels *affect* growth factor induced [ERK] phosphorylation . Regulation EPHB2 EDN1 12193071 980957 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( [ERK] ) and p38 mitogen activated protein (MAP) kinase were studied in rat and human renal glomerular mesangial cells . Regulation EPHB2 EDN1 15355882 1353865 Addition of exogenous PLD or PA in the medium reproduced the *effect* of on [ERK] activation and cell proliferation . Regulation EPHB2 EDN2 12193071 980958 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( [ERK] ) and p38 mitogen activated protein (MAP) kinase were studied in rat and human renal glomerular mesangial cells . Regulation EPHB2 EDN3 12193071 980959 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( [ERK] ) and p38 mitogen activated protein (MAP) kinase were studied in rat and human renal glomerular mesangial cells . Regulation EPHB2 EFNB1 20633976 2316729 Identification of expression in prostatic mesenchyme and a *role* for [EphB-EphrinB] signalling in prostate development . Regulation EPHB2 EGF 10383890 624665 The time course of ERK activity in both cell types coincided with the phosphorylation state of the EGF receptor , suggesting that altered regulation of EGF receptor phosphorylation or EGF receptor turnover produces an enhanced [ERK] *response* to in tumor cells . Regulation EPHB2 EGF 10550332 565068 To investigate if Raf-1-ERK activation is attributable to the epithelial component of ulcer margins , we studied the *effect* of on PKC , Ras , and [ERK] activities in a rat gastric epithelial cell line ( RGM1 ) . Regulation EPHB2 EGF 10585878 571587 However , PP2 inhibited [ERK] activation in response to NE and UTP , but not in *response* to or NGF . Regulation EPHB2 EGF 10647963 578007 Activation of [ERK] in *response* to or PMA was also reduced in cortical brain slices of 24-month-old rats . Regulation EPHB2 EGF 10751319 681515 However , *dependent* activation of endogenous [Erk] did not account for most of the Sp1 kinase activity , since Erk and additional Sp1 kinase activity analyzed in a solid-phase kinase assay eluted from an ion-exchange column in different fractions . Regulation EPHB2 EGF 11263267 764484 To investigate whether the *effect* of angiotensin (Ang) II or on cardiac fibroblast proliferation involved in activation of extracellular signal regulated kinase ( [ERK] ) 1/2 or Ca ( 2+ ) -calmodulin dependent protein kinase ( CCDPK ) mediated by protein kinase C (PKC)-zeta . Regulation EPHB2 EGF 11758828 887691 We examined whether is *involved* in [ERK] activation and whether ERK activation triggers epithelial proliferation in PHT gastric mucosa . Regulation EPHB2 EGF 11851354 913223 *Role* of Receptor and Pyk2 in endothelin-1 induced [ERK] activation in rat cardiomyocytes . Regulation EPHB2 EGF 11988485 936297 rPMT stimulates the ERK cascade via epidermal growth factor (EGF) receptor transactivation in cardiac fibroblasts , but receptor transactivation *plays* no role in [ERK] activation in cardiomyocytes . Regulation EPHB2 EGF 12037663 949291 The activation of hTERT mRNA expression by EGF was specifically blocked by MEK inhibitor , and in vitro kinase assays demonstrated that [ERK] is activated in *response* to . Regulation EPHB2 EGF 12923167 1151250 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to fibroblast growth factor and PDGF but not the . Regulation EPHB2 EGF 15252117 1274282 *dependent* activation of [ERK] and serum response element ( SRE ) are both up-regulated in PC12 cells stably overexpressing PLC-gamma1 , but knockdown of PLC-gamma1 by siRNA significantly reduces ERK activation . Regulation EPHB2 EGF 15640153 1381328 PGEs enhanced [Erk] activation and MMP-1 secretion in *response* to but inhibited Erk and MMP-1 when TNF-alpha and IL-1beta were the stimuli , indicating that the effects of PGEs on gastric cell responses are context dependent . Regulation EPHB2 EGF 15720812 1351918 Both Akt and [ERK] were rapidly phosphorylated in *response* to , with ERK phosphorylation being the weakest in PC3 cells . Regulation EPHB2 EGF 17043637 1724407 In *response* to , these cells demonstrated equivalent overall EGFR tyrosine phosphorylation and [ERK/MAP] kinase activation ; Regulation EPHB2 EGF 18096367 1855024 Finally , our data showed that , with overexpression of hSef , elevated levels of [Erk] phosphorylation and differentiation of rat pheochromocytoma ( PC12 ) cells occur in *response* to stimulation . Regulation EPHB2 EGF 18762250 1975632 Additionally , EGFR undergoes MEK1 dependent [ERK] consensus site phosphorylation in *response* to or cytokines such as growth hormone (GH) and prolactin (PRL) . Regulation EPHB2 EGF 19509291 2108659 Consequently , [Erk] activation in *response* to stimulation is regulated by the expression of GAREM in COS-7 and HeLa cells , which occurs independent of the presence of other binding proteins , such as Gab1 and SOS , to the activated EGF receptor . Regulation EPHB2 EGF 20230789 2237596 In this report , we show that serine282 residue of Nox activator 1 (NoxA1) is phosphorylated by [Erk] in *response* to resulting in desensitization of Nox1 activity . Regulation EPHB2 EGF 21882253 2668085 Celecoxib inhibited basal and EGF stimulated proliferation , hypoxia related HIF-1a recruitment/stabilization as well as hypoxia- and *dependent* activation of [ERK] and PI3K . Regulation EPHB2 EGF 22070748 2517012 Following a biocompatibility assessment , the nanoparticle induced interference at four specific targets within the EGF signaling process was evaluated : ( 1 ) nanoparticle-EGF association , ( 2 ) Akt and [Erk] phosphorylation , ( 3 ) Akt activity , and ( 4 ) dependent gene *regulation* . Regulation EPHB2 EGF 22245064 2559452 A simplified mathematical model of this scenario accurately predicted the experimental data , supporting the conclusion that the major mechanism by which MKPs influence acute stimulated [ERK] *responses* is the negative regulation of p38 , resulting in the positive regulation of ERK phosphorylation and activity . Regulation EPHB2 EGF 22776648 2627746 The optimum concentration of *effect* on [P-ERK] was 50 ng/ml . Regulation EPHB2 EGF 23509299 2772188 A cell-permeable peptide corresponding to this region disrupted the PDE8A/Raf-1 interaction in cells , thereby reducing [ERK] activation and the cellular *response* to . Regulation EPHB2 EGF 24043306 2857284 We conclude that Rac1 T108 is phosphorylated by [ERK] in *response* to , which plays an important role in regulating Rac1 . Regulation EPHB2 EGF 24126105 2867928 Depletion of Gab1 , using siRNA , decreased the [ERK] and Akt activation , cyclin D1 expression , and DNA synthesis in *response* to both and HGF . Regulation EPHB2 EGF 7865752 287238 Differential *effect* of NGF and on [ERK] in neuronally differentiated PC12 cells . Regulation EPHB2 EGF 8897883 392923 Also , in contrast to observations in neutrophils , the phosphatidylinositol 3-kinase ( PtdIns 3-kinase ) inhibitor , wortmannin ( 0.3-3 microM ) , failed to inhibit [ERK] activation in *response* to , carbachol , or TPA . Regulation EPHB2 EGF 9892211 586630 We have studied the *effects* of , IGF-I , and the protein kinase A (PKA) activator forskolin on the activation of p42/ extracellular signal regulated kinase ( [ERK] ) 2 , which is a key kinase in mediation of growth factor induced mitogenesis in prostate cancer cells . Regulation EPHB2 EGFR 11457825 850813 mu-Opioid receptor mediated [ERK] activation *involves* calmodulin dependent transactivation . Regulation EPHB2 EGFR 11502566 847679 Addition of EGFR tyrosine kinase inhibitors ( e.g. , tyrphostin AG-1478 ) abrogated bombesin induced extracellular signal regulated kinase ( ERK ) activation in Rat-1 cells but not in Swiss 3T3 cells , indicating the importance of cell context in determining the *role* of in [ERK] activation . Regulation EPHB2 EGFR 12719447 1093400 In contrast , ET-induced [ERK] activation and c-fos gene expression were predominantly *regulated* by . Regulation EPHB2 EGFR 12833145 1105815 RALT deltaEBR , a mutant unable to bind to ErbB RTKs , did not inhibit *dependent* activation of [ERK] and AKT , consistent with RALT exerting its suppressive activity towards these pathways at a receptor-proximal level . Regulation EPHB2 EGFR 15471881 1342460 The presence of AG1478 , an epidermal growth factor (EGF) receptor ( EGFR ) kinase inhibitor , had no effect on ERK or Ras activation , indicating that kinase activity is not *involved* in [ERK] activation by UVA . Regulation EPHB2 EGFR 15542601 1360695 In this study , we analyzed the *role* of the in RSV activation of [ERK] . Regulation EPHB2 EGFR 15843167 1398339 Furthermore , activation of the by doxorubicin was *responsible* for [ERK] activation and the subsequent attenuation of GJC . Regulation EPHB2 EGFR 15908804 1420110 *Effects* of endogenous signaling on DNA synthesis and [ERK] activation in a cytokine dependent hematopoietic cell line . Regulation EPHB2 EGFR 16565089 1555779 Taken together , our findings suggest that CD44 interaction with LARG and *plays* a pivotal role in Rho/Ras co-activation , PLC epsilon-Ca2+ signaling , and [Raf/ERK] up-regulation required for CaMKII mediated cytoskeleton function and in head and neck squamous cell carcinoma progression . Regulation EPHB2 EGFR 16644694 1553152 Conversely , Ex-4 induced [extracellular regulated kinase (ERK)] 1/2 activation in PL 45 cells in a GLP-1R-and *dependent* manner , whereas Ex-4 inhibited ERK1/2 phosphorylation in Hs 766T and CAPAN-1 cells . Regulation EPHB2 EGFR 18080320 1894777 Pretreatment with calcitriol , enhanced TNF induced *dependent* [ERK] activation and tyrosine phosphorylation of the EGFR , but abolished the EGFR-Src independent ERK activation . Regulation EPHB2 EGFR 19559020 2117208 A reduction of is *involved* in brefelamide induced inhibition of phosphorylation of [ERK] in human astrocytoma cells . Regulation EPHB2 EGFR 20563247 2280067 This caused an *dependent* increase in basal and EGF stimulated [ERK] phosphorylation but failed to restore tumor cell sensitivity to EGFR inhibition . Regulation EPHB2 EGFR 22718763 2638937 Here , we demonstrate that nonmuscle myosin II ( NM II ) is required for the internalization of the EGFR and to trigger the *dependent* activation of [ERK] and AKT . Regulation EPHB2 EGFR 22718763 2638945 Loss ( siRNA ) or inhibition ( 25 µm blebbistatin ) of NM II attenuates the internalization of the EGFR and impairs *dependent* activation of [ERK] and AKT . Regulation EPHB2 EGFR 22763976 2623352 Inhibition of kinase activity by AG494 in contrast to AG1478 had no *effect* on the activity of [ERK] in both cell lines . Regulation EPHB2 EGR1 21321112 2414951 In this report , we found that chronic exposure to hyperinsulinism caused persistent [Erk/MAPK] activity in adipocytes and enhanced insulin resistance in an *dependent* manner . Regulation EPHB2 EIF5A 23638878 2790790 Phosphorylation of [ERK] , p38 MAPK , and JNK was observed in *response* to adenovirus mediated over-expression of eIF5A1 or , along with phosphorylation and stabilization of the p53 tumor suppressor protein . Regulation EPHB2 EMD 23167467 2700308 Our results suggest that stimulates VEGF production partially via TGF-ß1 and FGF-2 in human gingival fibroblasts and that EMD induced VEGF production is *regulated* by [ERK] , p38 MAPK , and PI3K/Akt pathways . Regulation EPHB2 ENO1 22257123 2575377 In the present study , we investigated the *involvement* of in PI3K ( phosphoinositide 3-kinase ) /Akt and MAPK ( mitogen activated protein kinase ) [/ERK] ( extracellular-signal regulated kinase ) signalling , the two pathways triggered predominantly by neurotrophic factors . Regulation EPHB2 ENO2 22257123 2575378 In the present study , we investigated the *involvement* of in PI3K ( phosphoinositide 3-kinase ) /Akt and MAPK ( mitogen activated protein kinase ) [/ERK] ( extracellular-signal regulated kinase ) signalling , the two pathways triggered predominantly by neurotrophic factors . Regulation EPHB2 ENO3 22257123 2575379 In the present study , we investigated the *involvement* of in PI3K ( phosphoinositide 3-kinase ) /Akt and MAPK ( mitogen activated protein kinase ) [/ERK] ( extracellular-signal regulated kinase ) signalling , the two pathways triggered predominantly by neurotrophic factors . Regulation EPHB2 ENO4 22257123 2575376 In the present study , we investigated the *involvement* of in PI3K ( phosphoinositide 3-kinase ) /Akt and MAPK ( mitogen activated protein kinase ) [/ERK] ( extracellular-signal regulated kinase ) signalling , the two pathways triggered predominantly by neurotrophic factors . Regulation EPHB2 EPHA2 22916121 2657592 Similar to ephrin-A1 , doxazosin inhibited Akt and [ERK] kinase activities in an *dependent* manner . Regulation EPHB2 EPHA2 23318428 2860718 We here demonstrate that is *responsible* for Shp2 mediated [Erk] activation by phosphorylating Tyr542 and Tyr580 of Shp2 in the cells stimulated with growth factors . Regulation EPHB2 EPX 21860424 2574406 EpoR knockdown in melanoma cells resulted in diminished [ERK] phosphorylation in *response* to stimulation , decreased cell proliferation and increased response to the inhibitory effect of hypoxia and cisplatin in vitro . Regulation EPHB2 ERBB2 18535289 1945570 Cultured rat hepatocytes upregulate Akt and [ERK] in an *dependent* manner . Regulation EPHB2 ERBB2 21852536 2468835 Overexpression of maintains PDH flux by suppressing PDK4 expression in an Erk dependent manner , and [Erk] signaling also *regulates* PDH flux in ECM attached cells . Regulation EPHB2 ERBB2IP 23524970 2761888 The screen revealed that ( also known as ERBB2IP ) , a known [ERK] *regulator* , binds DSG1 . Regulation EPHB2 ERBB2IP 23711387 2801639 The inhibitory *role* of in [ERK] signaling has been demonstrated . Regulation EPHB2 ERRFI1 21190978 2396796 Furthermore , *regulated* [ERK] phosphorylation independent from its effects on EGFR . Regulation EPHB2 ESR1 19339617 2056698 These results demonstrate that E2-mediated neuroprotection and [ERK] activation *involve* activation of G-protein- and beta-arrestin mediated mechanisms . Regulation EPHB2 ESR1 22230296 2569224 Estrogen- and xenoestrogen induced [ERK] signaling in pituitary tumor cells *involves* interactions with G protein-ai and caveolin I . Regulation EPHB2 ETV6 15060146 1230464 These data indicate that is a constituent downstream of ERK in signal transduction systems and is physiologically *regulated* by [ERK] in molecular and biological features . Regulation EPHB2 FAS 25086185 2956913 Surprisingly , in *response* to suppression , we observed robust increases in both Akt and [ERK] phosphorylation . Regulation EPHB2 FASLG 21257927 2469711 Similarly , primary human small airways epithelial cells released IL-8 in *response* to soluble , and this was abrogated by inhibition of JNK and [ERK] . Regulation EPHB2 FFAR2 21698257 2446938 SCFAs and phenylacetamide-1 also elicited *dependent* activation of PKB , p38 and [ERK] and these responses were sensitive to pertussis toxin , indicating a role for Gi proteins . Regulation EPHB2 FGF1 12402043 1009390 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Regulation EPHB2 FGF1 12923167 1151251 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Regulation EPHB2 FGF1 16831426 1587175 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Regulation EPHB2 FGF1 17368052 1760147 We have shown previously that cutting or loading articular cartilage resulted in *dependent* activation of the [extracellularly regulated kinase (ERK)] , and induction of a number of chondrocyte regulatory proteins including tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases 1 and 3 . Regulation EPHB2 FGF1 17368052 1760174 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Regulation EPHB2 FGF10 12402043 1009391 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Regulation EPHB2 FGF10 12923167 1151252 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Regulation EPHB2 FGF10 16831426 1587176 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Regulation EPHB2 FGF10 17368052 1760175 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Regulation EPHB2 FGF11 12402043 1009392 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Regulation EPHB2 FGF11 12923167 1151253 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Regulation EPHB2 FGF11 16831426 1587177 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Regulation EPHB2 FGF11 17368052 1760176 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Regulation EPHB2 FGF12 12402043 1009393 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Regulation EPHB2 FGF12 12923167 1151254 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Regulation EPHB2 FGF12 16831426 1587178 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Regulation EPHB2 FGF12 17368052 1760177 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Regulation EPHB2 FGF13 12402043 1009394 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Regulation EPHB2 FGF13 12923167 1151255 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Regulation EPHB2 FGF13 16831426 1587179 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Regulation EPHB2 FGF13 17368052 1760178 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Regulation EPHB2 FGF14 12402043 1009395 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Regulation EPHB2 FGF14 12923167 1151256 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Regulation EPHB2 FGF14 16831426 1587180 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Regulation EPHB2 FGF14 17368052 1760179 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Regulation EPHB2 FGF16 12402043 1009396 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Regulation EPHB2 FGF16 12923167 1151257 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Regulation EPHB2 FGF16 16831426 1587181 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Regulation EPHB2 FGF16 17368052 1760180 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Regulation EPHB2 FGF17 12402043 1009397 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Regulation EPHB2 FGF17 12923167 1151258 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Regulation EPHB2 FGF17 16831426 1587182 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Regulation EPHB2 FGF17 17368052 1760181 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Regulation EPHB2 FGF18 12402043 1009398 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Regulation EPHB2 FGF18 12923167 1151259 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Regulation EPHB2 FGF18 16831426 1587183 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Regulation EPHB2 FGF18 17368052 1760182 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Regulation EPHB2 FGF18 18286540 1896498 Furthermore , *effects* of on [ERK] and AKT activation paralleled FGFR3 effects on these intracellular targets . Regulation EPHB2 FGF19 12402043 1009399 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Regulation EPHB2 FGF19 12923167 1151260 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Regulation EPHB2 FGF19 16831426 1587184 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Regulation EPHB2 FGF19 17368052 1760183 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Regulation EPHB2 FGF2 12402043 1009400 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Regulation EPHB2 FGF2 12923167 1151261 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Regulation EPHB2 FGF2 14872495 1208472 Cyclical loading of articular cartilage causes *dependent* activation of [ERK] and synthesis of TIMP-1 . Regulation EPHB2 FGF2 16831426 1587185 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Regulation EPHB2 FGF2 16840547 1613067 S179D PRL blocked [ERK] phosphorylation in *response* to , whereas continued coincubation caused a delayed and prolonged activation of ERK . Regulation EPHB2 FGF2 17368052 1760184 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Regulation EPHB2 FGF2 19286672 2072942 siRNA knockdown of p85beta in MM cells caused an increased [ERK] *response* to . Regulation EPHB2 FGF2 22731705 2659605 We have examined the *effects* of ( basic fibroblast growth factor ) on [p-ERK] ( phosphorylated extracellular signal regulated kinase ) through PDGFRß ( platelet derived growth factor receptor ß ) in the proliferation and migration of EPCs ( endothelial progenitor cells ) . Regulation EPHB2 FGF20 12402043 1009401 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Regulation EPHB2 FGF20 12923167 1151262 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Regulation EPHB2 FGF20 16831426 1587186 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Regulation EPHB2 FGF20 17368052 1760185 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Regulation EPHB2 FGF21 12402043 1009402 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Regulation EPHB2 FGF21 12923167 1151263 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Regulation EPHB2 FGF21 16831426 1587187 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Regulation EPHB2 FGF21 17368052 1760186 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Regulation EPHB2 FGF22 12402043 1009403 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Regulation EPHB2 FGF22 12923167 1151264 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Regulation EPHB2 FGF22 16831426 1587188 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Regulation EPHB2 FGF22 17368052 1760187 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Regulation EPHB2 FGF23 12402043 1009404 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Regulation EPHB2 FGF23 12923167 1151265 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Regulation EPHB2 FGF23 16831426 1587189 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Regulation EPHB2 FGF23 17368052 1760188 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Regulation EPHB2 FGF3 12402043 1009405 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Regulation EPHB2 FGF3 12923167 1151266 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Regulation EPHB2 FGF3 16831426 1587190 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Regulation EPHB2 FGF3 17368052 1760189 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Regulation EPHB2 FGF4 12402043 1009406 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Regulation EPHB2 FGF4 12923167 1151267 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Regulation EPHB2 FGF4 16831426 1587191 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Regulation EPHB2 FGF4 17368052 1760190 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Regulation EPHB2 FGF5 12402043 1009407 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Regulation EPHB2 FGF5 12923167 1151268 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Regulation EPHB2 FGF5 16831426 1587192 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Regulation EPHB2 FGF5 17368052 1760191 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Regulation EPHB2 FGF6 12402043 1009408 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Regulation EPHB2 FGF6 12923167 1151269 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Regulation EPHB2 FGF6 16831426 1587193 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Regulation EPHB2 FGF6 17368052 1760192 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Regulation EPHB2 FGF7 12402043 1009409 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Regulation EPHB2 FGF7 12923167 1151270 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Regulation EPHB2 FGF7 16831426 1587194 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Regulation EPHB2 FGF7 17368052 1760193 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Regulation EPHB2 FGF8 12402043 1009410 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Regulation EPHB2 FGF8 12923167 1151271 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Regulation EPHB2 FGF8 16831426 1587195 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Regulation EPHB2 FGF8 17368052 1760194 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Regulation EPHB2 FGF9 12402043 1009411 A non phosphorylated Spry mutant can not bind Grb2 and acts as a dominant negative , inducing prolonged activation of [ERK] in *response* to and promoting the FGF induced outgrowth of neurites in PC12 cells . Regulation EPHB2 FGF9 12923167 1151272 Compared with wild type cells , [ERK] activation was decreased in Y542F- or Y580F infected cells in *response* to and PDGF but not the epidermal growth factor . Regulation EPHB2 FGF9 16831426 1587196 Negative feedback predominates over cross-regulation to control [ERK] MAPK activity in *response* to signalling in embryos . Regulation EPHB2 FGF9 17368052 1760195 Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture , and deliver an *dependent* activation of [ERK] when loaded . Regulation EPHB2 FHL2 18356303 1925345 Our findings point to a *role* of in bundling of focal adhesion structures , in integrin mediated [ERK] activation , and subsequently in proper allocation of matrix proteins on the cell surface . Regulation EPHB2 FN1 11294892 801193 Urokinase receptor and *regulate* the [ERK] ( MAPK ) to p38 ( MAPK ) activity ratios that determine carcinoma cell proliferation or dormancy in vivo . Regulation EPHB2 FNTA 23045963 2689806 *Effects* of statins and inhibitors on [ERK] phosphorylation , apoptosis and cell viability in non-small lung cancer cells . Regulation EPHB2 FNTB 23045963 2689807 *Effects* of statins and inhibitors on [ERK] phosphorylation , apoptosis and cell viability in non-small lung cancer cells . Regulation EPHB2 FRS2 20652960 2322154 *regulates* [Erk] levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells . Regulation EPHB2 FSHB 15509729 1374772 Results showed that PD suppressed [ERK] activational and transcriptional *responses* to T . Regulation EPHB2 GAB1 12008033 940730 Since [ERK] is *regulated* by the phosphorylated , these data demonstrate that BCR triggered phosphorylation and signal amplification of Gab1/2 is a critical step in a life or death decision of B cells . Regulation EPHB2 GAB1 12446613 1017811 Notably , neither the [ERK] nor the STAT5 GH-dependent signaling outcome is *affected* by expression of the mutant with tyrosine 627 changed to phenylalanine . Regulation EPHB2 GAB1 12446613 1017812 Our results suggest selective *involvement* of in GH-induced [ERK] activation and implicate the Gab1 PH domain as critical in this involvement . Regulation EPHB2 GAB1 23318428 2860731 We found that ( Grb2 associated binder 1 ) was *involved* in the mutant Shp2 mediated [Erk] activation . Regulation EPHB2 GAB2 12008033 940729 Since [ERK] is *regulated* by the phosphorylated , these data demonstrate that BCR triggered phosphorylation and signal amplification of Gab1/2 is a critical step in a life or death decision of B cells . Regulation EPHB2 GABRA1 12223228 987721 These results indicate that ethanol 's inhibitory effect on [ERK] phosphorylation may *involve* the modulation of function . Regulation EPHB2 GABRA1 17916335 1819282 These results demonstrated that the changes in [ERK] phosphorylation in hippocampus and PFC were *regulated* by in a learning and memory paradigm under acute restraint stress conditions . Regulation EPHB2 GABRB2 12223228 987722 These results indicate that ethanol 's inhibitory effect on [ERK] phosphorylation may *involve* the modulation of function . Regulation EPHB2 GABRB2 17916335 1819283 These results demonstrated that the changes in [ERK] phosphorylation in hippocampus and PFC were *regulated* by in a learning and memory paradigm under acute restraint stress conditions . Regulation EPHB2 GABRG2 12223228 987723 These results indicate that ethanol 's inhibitory effect on [ERK] phosphorylation may *involve* the modulation of function . Regulation EPHB2 GABRG2 17916335 1819284 These results demonstrated that the changes in [ERK] phosphorylation in hippocampus and PFC were *regulated* by in a learning and memory paradigm under acute restraint stress conditions . Regulation EPHB2 GADD45G 14971655 1212204 Here , the aim was to study the effect of Cr(VI) transcriptional regulation of key cell cycle inhibitors and pro- and anti-apoptotic proteins , as well as the role of [ERK] activation in the genotoxic *response* . Regulation EPHB2 GAREM 19509291 2108658 Consequently , [Erk] activation in response to EGF stimulation is *regulated* by the expression of in COS-7 and HeLa cells , which occurs independent of the presence of other binding proteins , such as Gab1 and SOS , to the activated EGF receptor . Regulation EPHB2 GAREM 24003223 2851344 Furthermore , and Shp2 *regulate* [Erk] activity in EGF stimulated cells . Regulation EPHB2 GAREM 24003223 2851352 Eventually , *regulates* [Erk] activation in the presence of EGF or insulin like growth factor 1 . Regulation EPHB2 GDF15 15555917 1340106 *effects* on neurite extension and arborization are similar to , but not additive with , those of brain derived neurotrophic factor and reflect direct NRG-1 action on hippocampal neurons as these cells express the NRG-1 receptors erbB2 and erbB4 , the erbB-specific inhibitor PD158780 decreases NRG-1beta induced neurite outgrowth , and NRG-1beta stimulation induces p42/44 [ERK] phosphorylation . Regulation EPHB2 GDF9 19366876 2081621 *Effects* of on cell cycle regulators and [ERK42/44] in human granulosa cell proliferation . Regulation EPHB2 GDI1 10066681 593658 Overexpression of or DNRhoA did not *affect* angiotensin II-induced activation of [ERK] . Regulation EPHB2 GDI2 10066681 593659 Overexpression of or DNRhoA did not *affect* angiotensin II-induced activation of [ERK] . Regulation EPHB2 GDNF 18071753 1854352 alone prevents low-potassium induced caspase-3 activation and DNA fragmentation but does not *affect* either low-potassium induced [ERK] activation or PM damage . Regulation EPHB2 GH1 18499741 1939369 JAK2 , but not Src family kinases , is required for STAT , [ERK] , and Akt signaling in *response* to in preadipocytes and hepatoma cells . Regulation EPHB2 GJA1 21575204 2441435 AGE-BSA down-regulated expression in HAEC , mainly through reduced Cx43 transcription , and the process *involved* activation of [ERK] and p38 MAPK . Regulation EPHB2 GJA1 22277757 2575621 The PKCd independent activation of ERK by FGF2 was confirmed by Western blotting , as was the *dependent* enhancement of [ERK] activation . Regulation EPHB2 GNB2L1 20483033 2367792 At 7 days of final RACK1 administration , the *effects* of on Src and [p-ERK] disappeared , and morphine place preference was restored . Regulation EPHB2 GNB2L1 20483033 2367793 We demonstrated that *acts* on [ERK] activation via Src in morphine reward in mice . Regulation EPHB2 GNRH1 12960037 1143351 Activation of individual signaling pathways was able to partially mimic the desensitizing *effect* of on [ERK] , p38 MAPK , c-fos , and LHbeta but not on Gq/11 . Regulation EPHB2 GNRH1 15509729 1374770 In alpha T3 clonal gonadotrope cells , dihydrotestosterone did not activate ERK alone but enhanced and prolonged the [ERK] *responses* to , demonstrating direct effects on the gonadotrope . Regulation EPHB2 GNRH1 15509729 1374771 Thus , the [ERK] *response* to plus androgen was enhanced in both rat pituitary and alpha T3 cells . Regulation EPHB2 GNRH1 19179479 2049171 Thus , mediated [ERK] *responses* ( like PKC mediated ERK responses ) are dependent on protein neosynthesis and docking-domain dependent binding , but for GnRH activation ( unlike PKC activation ) , this does not reflect dependence on nuclear-inducible DUSPs . Regulation EPHB2 GNRH1 20685880 2322787 We conclude that DUSP1 feedback activity modulates [ERK] activation and the transcriptional *response* to . Regulation EPHB2 GPER1 23772748 2828513 In conclusion , icariin decreased type IV collagen and fibronectin accumulation induced by high glucose in mesangial cells by inhibiting TGF-ß production , as well as Smad and [ERK] signalling in a *dependent* manner . Regulation EPHB2 GRAP2 11745456 888985 These findings suggest that both [ERK] and cellular protein tyrosine kinase activation are involved in 12 ( S ) -HETE induced pancreatic cancer cell proliferation but and JNK/SAPK are not *involved* in this mitogenic effect . Regulation EPHB2 GRAP2 12670923 1076214 Modulation of ERK/p38 activity ratio by multiple pharmacological and genetic interventions confirms that high ERK/p38 ratio favors tumor growth , whereas high p38/ERK ratio induces tumor growth arrest ( dormancy ) in vivo and that [ERK] is negatively *regulated* by . Regulation EPHB2 GRAP2 16464862 1548100 In contrast , MAPK inhibitors had no detectable *effect* on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Regulation EPHB2 GRAP2 17475625 1761403 MEK inhibitors UO126 and PD98059 inhibited both CagA independent and -dependent MMP-1 secretion , whereas p38 inhibition enhanced MMP-1 secretion and ERK activation , suggesting negative *regulation* of MMP-1 and [ERK] . Regulation EPHB2 GRB2 10400627 628256 These findings strongly support distinct *roles* for and Shc in controlling [ERK] and JNK activation after EGF stimulation . Regulation EPHB2 GRB2 10976990 729641 In contrast to their implication in epidermal growth factor (EGF) receptor tyrosine kinase signaling , the adaptor protein Shc , the complex , and the small G protein Ras were not *involved* in the activation of [Erk] induced by either LPA or PGF2alpha in MC3T3-E1 cells , suggesting that activation of Erk by Gi and Gq protein coupled receptors is Ras independent in these cells . Regulation EPHB2 GRB2 11791173 901787 Here we determined the efficacy of Shc and N-Shc toward Erk activation in NGF treated PC12 cells , and found that N-Shc transduced *dependent* [Erk] activation less efficiently than Shc . Regulation EPHB2 GRB2 20618341 2334786 However , silencing of SOS2 , and PKCa and ßI does not *affect* phosphorylation of Akt or [Erk] , indicating that activation of the PI3K/Akt and the Erk signalling cascade are independent of the F. tularensis triggered Ras activation . Regulation EPHB2 GRIN2A 15924861 1414120 Differential *roles* of and NR2B containing NMDA receptors in [Ras-ERK] signaling and AMPA receptor trafficking . Regulation EPHB2 GRIN2A 21653857 2442146 Accordingly , primary hippocampal cultures of IQGAP1 ( -/- ) neurons exhibited reduced surface expression of NR2A and disrupted [ERK] signaling in *response* to dependent NMDAR stimulation . Regulation EPHB2 GRK1 16887887 1632417 In conclusion , we demonstrate the existence of a beta-arrestin *dependent* , regulated mechanism for [ERK] activation by the FSH-R . Regulation EPHB2 GRK4 16887887 1632419 In conclusion , we demonstrate the existence of a beta-arrestin *dependent* , regulated mechanism for [ERK] activation by the FSH-R . Regulation EPHB2 GRK5 16887887 1632420 In conclusion , we demonstrate the existence of a beta-arrestin *dependent* , regulated mechanism for [ERK] activation by the FSH-R . Regulation EPHB2 GRK6 16887887 1632421 In conclusion , we demonstrate the existence of a beta-arrestin *dependent* , regulated mechanism for [ERK] activation by the FSH-R . Regulation EPHB2 GRK7 16887887 1632418 In conclusion , we demonstrate the existence of a beta-arrestin *dependent* , regulated mechanism for [ERK] activation by the FSH-R . Regulation EPHB2 GRM1 12437585 1016199 The receptor mediated [ERK] *response* was almost completely attenuated by pertussis toxin (PTx) pretreatment , whereas the mGlu5a-ERK response , and the phosphoinositide response to activation of either receptor , was PTx-insensitive . Regulation EPHB2 GRM1 24045944 2862758 Substitutions of critical residues in the motif reduce mGluR1 association with lipid rafts and agonist induced , *dependent* activation of extracellular-signal activated kinase1/2 MAP kinase ( [ERK-MAPK] ) . Regulation EPHB2 GRPR 15361544 1334170 In this study , we demonstrate that ( GRPr ) *regulates* [ERK] through multiple pathways in a single cell type depending upon receptor expression and agonist concentration . Regulation EPHB2 HGF 11804875 903398 Further , we investigated the molecular mechanisms underlying the effects of HGF and IFN-gamma in BEAS-2B cells and found that the MEK1 inhibitor PD98059 , but not the p38 M-associated protein kinase inhibitor SB203580 , abrogates HGF induced [ERK] activation and proliferation in *response* to and serum . Regulation EPHB2 HGF 15194438 1259787 In contrast , [MAPK/ERK] phosphorylation was higher in *response* to and lasted longer , relative to IGF-I . Regulation EPHB2 HGF 15367691 1294844 Embryonic IMCD cells expressing predominantly Gpc3 proliferated and migrated in *response* to but activated [ERK] only transiently and failed to form tubules . Regulation EPHB2 HGF 19403526 2095584 Here , we characterize PhLP-M1-G149 , a Gbetagamma interacting construct derived from phosducin-like protein 1 (PhLP) as a differential inhibitor of Gbetagamma , which , in endothelial cells , prevented sphingosine 1-phosphate induced phosphorylation of AKT , glycogen synthase kinase 3beta , cell migration , and tubulogenesis , while having no effect on [ERK] phosphorylation or dependent *responses* . Regulation EPHB2 HGF 19427096 2101217 Decreased expression of c-Met , the receptor for hepatocyte growth factor , was also detected in the Hn1 depleted cells , however *dependent* stimulation of [phosphorylated-ERK] was unaffected . Regulation EPHB2 HGF 24126105 2867929 Depletion of Gab1 , using siRNA , decreased the [ERK] and Akt activation , cyclin D1 expression , and DNA synthesis in *response* to both EGF and . Regulation EPHB2 HMGB1 17697615 1782248 The *effects* of on activation of p38 , c-Jun amino-terminal kinase (JNK) , and extracellular-signal regulated protein kinase ( [ERK] ) and mitogen activated protein kinase (MAPK) in K562 cells were assayed by using Western blotting . Regulation EPHB2 HMGB1 21944254 2487914 The results suggest that *regulates* JNK and [ERK] required for autophagy , which provides a potential drug target for therapeutic interventions in childhood CML . Regulation EPHB2 HRAS 10749883 698493 These data clearly demonstrate that the alpha-thrombin induced activation coordinately *regulates* [ERK] and PI 3-kinase activities , both of which are required for expression of cyclin D1 protein and progression through G ( 1 ) . Regulation EPHB2 HRAS 10976990 729642 In contrast to their implication in epidermal growth factor (EGF) receptor tyrosine kinase signaling , the adaptor protein Shc , the Grb2/Sos complex , and the small G protein were not *involved* in the activation of [Erk] induced by either LPA or PGF2alpha in MC3T3-E1 cells , suggesting that activation of Erk by Gi and Gq protein coupled receptors is Ras independent in these cells . Regulation EPHB2 HRAS 11269657 797346 Arsenite inhibits *dependent* activation of [ERK] but activates ERK in the presence of oncogenic Ras in baboon vascular smooth muscle cells . Regulation EPHB2 HRAS 11278310 810923 In contrast , inhibition of or Src had no *effect* on the sustained [ERK] activity , which was critically dependent on phosphatidylinositol 3-kinase . Regulation EPHB2 HRAS 11791173 901788 Here we determined the efficacy of Shc and N-Shc toward Erk activation in NGF treated PC12 cells , and found that N-Shc transduced *dependent* [Erk] activation less efficiently than Shc . Regulation EPHB2 HRAS 12014647 941637 To examine the *role* of the transforming in controlling [ERK] signaling , transfection of an activated Ha-ras allele was tested in a squamous cell carcinoma cell line . Regulation EPHB2 HRAS 12082537 958586 In exponentially growing cells , oncogenic had no *effect* on proliferation rates , [Erk] phosphorylation , or the level of cyclin D1 , and Ras-induction did not confer serum independent growth . Regulation EPHB2 HRAS 12193071 981004 Thus , p38 MAP kinase stimulation could perhaps partially account for ET-1 contractive properties , whereas ET-1 induced cell proliferation occurs primarily via *dependent* activation of the [ERK] . Regulation EPHB2 HRAS 12855697 1134967 This unresponsiveness is associated with the constitutive activation of the small G protein , Rap1 , and the lack of *dependent* activation of [ERK] . Regulation EPHB2 HRAS 12902324 1150291 Co-expression of DN-TRAF6 and N17Ras completely inhibited CpG DNA induced COX2-3'-UTR-luciferase activity , indicating the *involvement* of in CpG DNA mediated [ERK] and COX2-3'-UTR regulation . Regulation EPHB2 HRAS 15029245 1228116 Developmentally regulated *role* for in coupling NMDA glutamate receptors to Ras , [Erk] and CREB . Regulation EPHB2 HRAS 16214133 1468867 In addition , transfection of ES cells with DN-Src , or DN-Ras partially inhibited 8-Br-cAMP induced ERK1/2 and consequently PLD activation , whereas cotransfection of DN-Src and DN-Ras completely inhibited ERK1/2 and PLD activation , suggesting that Src and independently *regulate* [ERK/PLD] activation . Regulation EPHB2 HRAS 16709153 1598865 However , a biochemical link between PE and GAP inactivation is missing and GEF stimulation is hard to reconcile with the observation that dominant negative S17N-Ras does not compromise *dependent* [ERK] ( extracellular-signal regulated kinase ) activation by PE . Regulation EPHB2 HRAS 17000055 1647266 Post-ischemia reperfusion resulted in the phosphorylation of [ERK] in a *dependent* manner ; Regulation EPHB2 HRAS 17045653 1666549 In the present study , we investigated the *role* of in FLG- and LPS mediated signaling in [ERK] activation in chicken heterophils . Regulation EPHB2 HRAS 17174095 1688103 Kinase Suppressor of Ras (KSR) is a molecular scaffold that interacts with the core kinase components of the ERK cascade , Raf , MEK , and ERK and provides spatial and temporal regulation of *dependent* [ERK] cascade signaling . Regulation EPHB2 HRAS 17873330 1796088 The aim of this work is to evaluate if can be induced by TSH in rat thyroids , and whether [extracellular regulated kinase (ERK)] may be *involved* in the subsequent intracellular signalling cascade . Regulation EPHB2 HRAS 19015044 2035059 Under basal conditions , EGFR activated [ERK] in a classical *dependent* manner . Regulation EPHB2 HRAS 21678474 2483652 Furthermore , we demonstrate the mechanism for PLD1 activation of [ERK] *involves* . Regulation EPHB2 HRAS 23363700 2747753 is greatly *involved* in determining and regulating directionality , [ERK] is its key effector for starting , driving and regulating directional movement . Regulation EPHB2 HRAS 23893412 2839581 The first step of *dependent* activation of [ERK] signaling is Ras binding to members of the Raf family of MAP kinase kinase kinases , C-Raf and B-Raf . Regulation EPHB2 HRAS 9432981 482445 Coexpression of the dominant negative did not *affect* TRAF6 mediated [ERK] activity , suggesting that TRAF6 may activate ERK along a Ras independent pathway . Regulation EPHB2 HRAS 9564040 500709 In PKC depleted cells , Ang II increased Ras-GTP level and activated Raf and [ERK] in a *dependent* manner . Regulation EPHB2 HRAS 9632795 513085 These observations suggest that Gab1 acts as an adapter molecule in transmitting signals to ERK MAP kinase for the cytokine receptor gp130 and that SHP-2 , PI-3 kinase , and are *involved* in Gab1 mediated [ERK] activation . Regulation EPHB2 HRAS 9843397 553054 ( c ) [ERK] activation is *independent* of the upstream mediators and Raf-1 . Regulation EPHB2 HRG 9712155 527225 A MEK specific inhibitor , PD98059 , which inhibited activation of [ERK] in *response* to , completely blocked HRG induced differentiation and reversed cell growth arrest . Regulation EPHB2 HSPG2 12039977 949573 Thus , proximal tubular OK cells express a CaR that mediates Ca ( 2+ ) ( i ) mobilization and PIP ( 2 ) <-PLC> *dependent* [ERK] activation in response to AGAs and thus could play a role in AGA induced nephrotoxicity . Regulation EPHB2 HSPG2 15750341 1379877 These findings indicate that [ERK] phosphorylation in response to glycated LDL *involves* the activation of PKC , , and MEK , but is independent of intracellular Ca2+ . Regulation EPHB2 HSPG2 19747075 2168249 These data suggest that the mitogenic effect of CMS2MS2 on fibroblasts is independent of its proteolytic activity , requires [ERK] phosphorylation , and *involves* activation of . Regulation EPHB2 HTC1 18455431 1921308 Concomitantly , the *effect* of <5-HT(2A/C)> , but not 5-HT(1A) , on [ERK] activation was abolished in stressed animals . Regulation EPHB2 HTC2 18455431 1921309 Concomitantly , the *effect* of <5-HT(2A/C)> , but not 5-HT(1A) , on [ERK] activation was abolished in stressed animals . Regulation EPHB2 HTR1A 18455431 1921310 Concomitantly , the *effect* of 5-HT(2A/C) , but not <5-HT(1A)> , on [ERK] activation was abolished in stressed animals . Regulation EPHB2 HTT 22334892 2554030 In *response* to mutant , [ERK] is activated and directs a protective transcriptional response and inhibits caspase activation . Regulation EPHB2 IFIT1 11164895 763152 To determine if ( Lck ) was *involved* in calcium induced [ERK] activation , we stimulated the p56 ( Lck ) negative Jurkat cell derivatives , J.CaM1.6 and J.CaM1/Rep3 , with ionomycin . Regulation EPHB2 IFITM1 19499152 2091875 Our study showed the interaction of and CAV-1 enhanced CAV-1 's inhibitory *effect* on [ERK] activation , whereas the IFITM1 did not activate ERK directly . Regulation EPHB2 IGF1 16487514 1534903 The induced increase in DNA replication was abolished by LY294002 and only partially inhibited by PD98059 , suggesting that phosphoinositol-3' kinase (PI-3'K) and to a lesser extent [MEK/Erk] signaling were *involved* . Regulation EPHB2 IGF1 19217812 2086499 [IGF-IR/ERK] content and *response* to and insulin in adipocytes from small for gestational age children . Regulation EPHB2 IGF1 21389330 2438271 Together , these results suggest that the nutritionally managed could be *regulating* the activation of the [MAPK/ERK] and the PI3K/Akt signaling pathways differentially according to the nutritional status , triggering different effects in growth parameters and therefore contributing to somatic growth in fish . Regulation EPHB2 IGF1 23650573 2714288 In HEK293 cells , IGF-1R signaling pathways are activated in *response* to , which induces obvious phosphorylations of receptor tyrosine and Akt , [ERK] . Regulation EPHB2 IGF1 9892211 586631 We have studied the *effects* of EGF , , and the protein kinase A (PKA) activator forskolin on the activation of p42/ extracellular signal regulated kinase ( [ERK] ) 2 , which is a key kinase in mediation of growth factor induced mitogenesis in prostate cancer cells . Regulation EPHB2 IGF1R 19574224 2122207 we validated that [MEK-ERK] signaling was also induced in an *dependent* manner in some cancer cell lines . Regulation EPHB2 IGFBP5 16007340 1431308 We identified RASSF1C , a member of the RASSF1 gene products , as a IGFBP-5 binding partner and as a potential mediator of *effects* on [ERK] phosphorylation and cell proliferation . Regulation EPHB2 IGFBP5 16007340 1431309 *effects* on [ERK] phosphorylation were evaluated by immunoblot analysis . Regulation EPHB2 IGFBP5 16007340 1431313 Our findings that silencing of RASSF1C results in the reduction of osteoblast cell proliferation and that IGFBP-5 treatment increases phosphorylation of ERK-1/2 raise the possibility that RASSF1C , a Ras effector , could , in part , contribute to mediating the *effects* of on [ERK] phosphorylation and , consequently , cell proliferation . Regulation EPHB2 IL10 12828555 1104991 The above findings suggest a unidirectional negative autocrine regulation of IL-12 by IL-10 in activated DCs and that activation of [ERK] *involves* the differential production of and IL-12 by activated DCs . Regulation EPHB2 IL10 24737107 2943031 TLR mediated STAT3 and [ERK] activation *controls* secretion by human B cells . Regulation EPHB2 IL12A 11781388 900340 These findings suggest that TNF-alpha induced [ERK] activation negatively *controls* maturation and production in murine DC . Regulation EPHB2 IL12A 12828555 1104992 The above findings suggest a unidirectional negative autocrine regulation of IL-12 by IL-10 in activated DCs and that activation of [ERK] *involves* the differential production of IL-10 and by activated DCs . Regulation EPHB2 IL12B 11781388 900341 These findings suggest that TNF-alpha induced [ERK] activation negatively *controls* maturation and production in murine DC . Regulation EPHB2 IL12B 12828555 1104993 The above findings suggest a unidirectional negative autocrine regulation of IL-12 by IL-10 in activated DCs and that activation of [ERK] *involves* the differential production of IL-10 and by activated DCs . Regulation EPHB2 IL17RD 21663947 2459708 Using luciferase reporter assays and western blot analysis , we detected the *effect* of on [MAPK/ERK] mediated FGF2 signaling . Regulation EPHB2 IL1A 11754748 898851 PD98059 , a specific inhibitor of the ERK activating kinase MEK1 , also abolished the *effects* of on [ERK] activation and osteoclast survival . Regulation EPHB2 IL1A 12632422 1067959 [ERK] signaling in *response* to in chondrocyte monolayers exhibited a pattern that was distinct from that in other culture systems , suggesting that the extracellular matrix plays an important regulatory role in modulating the response to extracellular stimuli . Regulation EPHB2 IL1A 16436473 1554460 Taken together , we have outlined a novel transduction pathway implicating PKC-delta as a critical component of the *dependent* activation of [ERK] in VSM cells . Regulation EPHB2 IL1A 21697093 2465466 SIRT1 activation promotes induction of [ERK] and p38 kinase activities , but not JNK , in *response* to . Regulation EPHB2 IL1B 12934647 1132840 Salicylate inhibited the and TNF-alpha induced COX-2 expressions , *regulated* the activation of [ERK] , IKK and IkappaB degradation , and the subsequent activation of NF-kappaB , in neonatal rat ventricular cardiomyocytes . Regulation EPHB2 IL1B 15831571 1417981 Activation of p38 and [ERK] in *response* to was also dependent on L-type Ca ( 2+ ) influx . Regulation EPHB2 IL2 11331873 808928 A tyrosine mutant of SOCS-3 still blocks STAT phosphorylation , but also strongly inhibits *dependent* activation of [ERK] and cell proliferation . Regulation EPHB2 IL2 14680820 1179160 Unexpectedly , dominant negative Ras17N blocked activation of Ras and [ERK] in *response* to engagement but not TCR/CD3 ligation . Regulation EPHB2 IL2 15170389 1280328 Expression of the Gab2 Tyr-614 -- > Phe ( Y614F ) mutant , defective in SHP-2 association , prevents ERK ( extracellular-signal regulated kinase ) activation and expression of a luciferase reporter plasmid driven by the c-fos SRE ( serum response element ) , indicating that interaction of SHP-2 with Gab2 is required for [ERK] activation in *response* to . Regulation EPHB2 IL2 24487322 2913632 Specific and nonspecific stimulation of LLO56 and LLO118 T cells , which transgenically express a TCR specific for the same Listeria monocytogenes epitope , elicited distinct and phosphorylated kinase [Erk] *responses* , the strength of which was set in the thymus and maintained in the periphery in proportion to the avidity of the binding of the TCR to the self peptide-MHC complex . Regulation EPHB2 IL3 11335710 827499 To investigate the mechanism leading to decreased activation of Erks , we investigated effects on SHP2 and Gab2 , both implicated in *regulation* of [Erk] activation . Regulation EPHB2 IL3 15465815 1342226 Augmentation of [ERK] activation and proliferation in *response* to was also observed in Spred-1-deficient bone marrow derived mast cells . Regulation EPHB2 IL3 17374739 1760232 Gab2-deficient c-Kit ( + ) Lin ( - ) cells also demonstrate impaired activation of extracellular signal regulated kinase ( [ERK] ) and S6 in *response* to , which supports defects in activating the phosphatidylinositol-3 kinase (PI-3K) and mitogen associated protein kinase (MAPK) signaling cascades . Regulation EPHB2 IL6 10899938 712584 Both *effects* of on STAT3 and [MAPK/ERK] activation were effectively counteracted by LavA treatment . Regulation EPHB2 IL8 16990258 1647137 Although both mutant and wild-type receptors could mediate Akt and [Erk] activation in *response* to , the level of activation of these two kinases was much lower in the cell line expressing the mutant receptors . Regulation EPHB2 INHBA 24606069 2933887 Finally , we found that and myostatin activate Smad-2/3 signaling but do not *affect* [ERK] or p38 signaling in both myometrial and leiomyoma cells . Regulation EPHB2 INS 10400063 628090 Thus , is *involved* in [ERK] regulation in fetal astrocytes . Regulation EPHB2 INS 12374468 996589 To assess insulin receptor (IR) , Shc , STAT-1 , [ERK] , and Akt phosphorylation in *response* to in lacrimal gland and salivary gland , tissues from female and male rats ( n = 5-8/group ) were submitted to immunoprecipitation and immunoblotting or Western blotting protocol , and phosphorylation level was determined by densitometry . Regulation EPHB2 INS 15509697 1328044 In the present study , the *effects* of 170 nM on IR , GLUT4 and GLUT8 mRNA levels , Akt and [Erk] phosphorylation , GLUT4 translocation and methyl glucose transport were studied in cultured day 3 to day 6 rabbit embryos . Regulation EPHB2 INS 15781236 1385455 Direct interaction between ERK and caveolin-2 was confirmed by immunoprecipitation and phosphorylated [ERK] increased the specific interaction in *response* to . Regulation EPHB2 INS 16246039 1471364 Oxidized low-density lipoprotein inhibits *dependent* phosphorylation of the signalling kinases [ERK] ( extracellular-signal regulated kinase ) and PKB/Akt . Regulation EPHB2 INS 19217812 2086500 [IGF-IR/ERK] content and *response* to IGF-I and in adipocytes from small for gestational age children . Regulation EPHB2 INS 20924651 2364692 Taken together , our data indicate that PI3K-C2a may be a crucial factor in the stimulation of [ERK] activity in *response* to serum or , whereas it is less important for the stimulation of PKB/Akt activity in response to insulin . Regulation EPHB2 INS 22641065 2763360 We then examined whether CPE regulates , a common upstream *regulator* of [ERK] and Akt . Regulation EPHB2 INS 9753291 533893 We studied the *effects* of ( 20 U/rat ) and epinephrine ( 25 microg/100 g body wt ) injected in vivo on [ERK] and JNK signaling in skeletal muscle from Sprague-Dawley rats . Regulation EPHB2 IQGAP1 16135787 1450342 We previously documented that binds extracellular signal regulated kinase ( ERK ) 2 and *regulates* growth factor stimulated [ERK] activity . Regulation EPHB2 IQGAP1 17563371 1763018 We previously documented that binds ERK and MAPK kinase ( MEK ) and *regulates* EGF stimulated MEK and [ERK] activity . Regulation EPHB2 IQGAP1 18567582 1946392 binds to and *regulates* the activities of [ERK] , MEK , and B-Raf . Regulation EPHB2 IRS1 23607966 2795235 mTORC1 inhibition induces pain via *dependent* feedback activation of [ERK] . Regulation EPHB2 IRS4 17408801 1736030 Our results suggest that PKC-epsilon mediates the *effect* of on [ERK] activity . Regulation EPHB2 ISL2 22183394 2531283 Examples of this are the repression of EphB1 by , and Vax1/Vax2 *regulation* of [EphB2/EphB3] expression . Regulation EPHB2 ITGA4 9092580 422125 Inhibition of tyrosine kinase activity with genistein ( 10 microg/ml ) as well as selective MAP kinase inhibition with the MEK-1 inhibitor PD98059 abolished the *dependent* [ERK] tyrosine phosphorylation , inhibited NF kappaB nuclear binding , and abrogated tissue factor expression induced by both VLA-4 cross linking and adhesion to fibronectin in THP-1 cells and human peripheral blood monocytes . Regulation EPHB2 ITGAV 18410576 1894102 The anti-alphavbeta3 integrin antibody could also inhibit ERK activation , suggesting the possible *role* of on the regulation of [ERK] and cell migration . Regulation EPHB2 ITGB1 9092580 422126 Inhibition of tyrosine kinase activity with genistein ( 10 microg/ml ) as well as selective MAP kinase inhibition with the MEK-1 inhibitor PD98059 abolished the *dependent* [ERK] tyrosine phosphorylation , inhibited NF kappaB nuclear binding , and abrogated tissue factor expression induced by both VLA-4 cross linking and adhesion to fibronectin in THP-1 cells and human peripheral blood monocytes . Regulation EPHB2 ITGB3 18410576 1894103 The anti-alphavbeta3 integrin antibody could also inhibit ERK activation , suggesting the possible *role* of on the regulation of [ERK] and cell migration . Regulation EPHB2 JAG1 20833210 2330858 Increased expression upon TGFß1 exposure required Smad3 signalling , and was also *regulated* by PI3K and [ERK] . Regulation EPHB2 JAK2 11313464 805480 These results indicate that the interaction between TFII-I and [ERK] , which is essential for its activity , can be *regulated* by through phosphorylation of TFII-I at tyrosine 248 . Regulation EPHB2 JAK2 14551204 1185953 Previous work has shown that inhibition of Jak2 via the pharmacological compound AG490 blocks the angiotensin II (Ang II) dependent activation of ERK2 , thereby suggesting an essential *role* of in [ERK] activation . Regulation EPHB2 JAK2 14551204 1185957 However , recent studies have thrown into question the specificity of AG490 and therefore the *role* of in [ERK] activation . Regulation EPHB2 JAK2 16740977 1599021 The activation of [ERK] and Akt but not p38 MAPK was *dependent* . Regulation EPHB2 JAM3 24584816 2938469 *affects* ß1and [ERK] activation in HDLEC , thus promoting lymphangiogenesis and nodal metastasis . Regulation EPHB2 JUN 21814482 2462829 Dimerumic acid inhibits SW620 cell invasion by attenuating H2O2 mediated MMP-7 expression via JNK/C-Jun and [ERK/C-Fos] activation in an *dependent* manner . Regulation EPHB2 KCNH4 18463290 1910084 experiments with hBVR nuclear export signal (NES) and nuclear localization signal ( NLS ) mutants demonstrated its critical *role* in the nuclear localization of IGF stimulated [ERK] for activation . Regulation EPHB2 KDR 14704231 1225434 Localization of and PLD2 in endothelial caveolae is *involved* in VEGF induced phosphorylation of MEK and [ERK] . Regulation EPHB2 KLF5 17158781 1687888 Thus , *regulates* [MEK/ERK] signaling via EGFR and is also downstream of MAPK signaling , providing a novel mechanism for signal amplification or suppression and control of proliferation in basal cells . Regulation EPHB2 KLK8 21508957 2428624 Stress results in *dependent* cleavage of [EphB2] in the amygdala causing dissociation of EphB2 from the NR1 subunit of the NMDA receptor and promoting membrane turnover of EphB2 receptors . Regulation EPHB2 KRAS 10749883 698494 These data clearly demonstrate that the alpha-thrombin induced activation coordinately *regulates* [ERK] and PI 3-kinase activities , both of which are required for expression of cyclin D1 protein and progression through G ( 1 ) . Regulation EPHB2 KRAS 10976990 729643 In contrast to their implication in epidermal growth factor (EGF) receptor tyrosine kinase signaling , the adaptor protein Shc , the Grb2/Sos complex , and the small G protein were not *involved* in the activation of [Erk] induced by either LPA or PGF2alpha in MC3T3-E1 cells , suggesting that activation of Erk by Gi and Gq protein coupled receptors is Ras independent in these cells . Regulation EPHB2 KRAS 11269657 797347 Arsenite inhibits *dependent* activation of [ERK] but activates ERK in the presence of oncogenic Ras in baboon vascular smooth muscle cells . Regulation EPHB2 KRAS 11278310 810924 In contrast , inhibition of or Src had no *effect* on the sustained [ERK] activity , which was critically dependent on phosphatidylinositol 3-kinase . Regulation EPHB2 KRAS 11791173 901789 Here we determined the efficacy of Shc and N-Shc toward Erk activation in NGF treated PC12 cells , and found that N-Shc transduced *dependent* [Erk] activation less efficiently than Shc . Regulation EPHB2 KRAS 12082537 958587 In exponentially growing cells , oncogenic had no *effect* on proliferation rates , [Erk] phosphorylation , or the level of cyclin D1 , and Ras-induction did not confer serum independent growth . Regulation EPHB2 KRAS 12193071 981005 Thus , p38 MAP kinase stimulation could perhaps partially account for ET-1 contractive properties , whereas ET-1 induced cell proliferation occurs primarily via *dependent* activation of the [ERK] . Regulation EPHB2 KRAS 12855697 1134968 This unresponsiveness is associated with the constitutive activation of the small G protein , Rap1 , and the lack of *dependent* activation of [ERK] . Regulation EPHB2 KRAS 12902324 1150292 Co-expression of DN-TRAF6 and N17Ras completely inhibited CpG DNA induced COX2-3'-UTR-luciferase activity , indicating the *involvement* of in CpG DNA mediated [ERK] and COX2-3'-UTR regulation . Regulation EPHB2 KRAS 15029245 1228117 Developmentally regulated *role* for in coupling NMDA glutamate receptors to Ras , [Erk] and CREB . Regulation EPHB2 KRAS 16214133 1468868 In addition , transfection of ES cells with DN-Src , or DN-Ras partially inhibited 8-Br-cAMP induced ERK1/2 and consequently PLD activation , whereas cotransfection of DN-Src and DN-Ras completely inhibited ERK1/2 and PLD activation , suggesting that Src and independently *regulate* [ERK/PLD] activation . Regulation EPHB2 KRAS 16709153 1598866 However , a biochemical link between PE and GAP inactivation is missing and GEF stimulation is hard to reconcile with the observation that dominant negative S17N-Ras does not compromise *dependent* [ERK] ( extracellular-signal regulated kinase ) activation by PE . Regulation EPHB2 KRAS 17000055 1647267 Post-ischemia reperfusion resulted in the phosphorylation of [ERK] in a *dependent* manner ; Regulation EPHB2 KRAS 17045653 1666550 In the present study , we investigated the *role* of in FLG- and LPS mediated signaling in [ERK] activation in chicken heterophils . Regulation EPHB2 KRAS 17174095 1688104 Kinase Suppressor of Ras (KSR) is a molecular scaffold that interacts with the core kinase components of the ERK cascade , Raf , MEK , and ERK and provides spatial and temporal regulation of *dependent* [ERK] cascade signaling . Regulation EPHB2 KRAS 17873330 1796089 The aim of this work is to evaluate if can be induced by TSH in rat thyroids , and whether [extracellular regulated kinase (ERK)] may be *involved* in the subsequent intracellular signalling cascade . Regulation EPHB2 KRAS 19015044 2035060 Under basal conditions , EGFR activated [ERK] in a classical *dependent* manner . Regulation EPHB2 KRAS 21678474 2483653 Furthermore , we demonstrate the mechanism for PLD1 activation of [ERK] *involves* . Regulation EPHB2 KRAS 23155002 2723157 These results demonstrate the versatility of the BCH domain of BPGAP1 in *regulating* [ERK] signaling by involving and SmgGDS and support the unique role of BPGAP1 as a dual regulator for Ras and Rho signaling in cell morphogenesis and differentiation . Regulation EPHB2 KRAS 23363700 2747754 is greatly *involved* in determining and regulating directionality , [ERK] is its key effector for starting , driving and regulating directional movement . Regulation EPHB2 KRAS 23455880 2781793 The grade of resistance appears to correlate with the individual *dependent* intrinsic activation of [ERK] . Regulation EPHB2 KRAS 23893412 2839582 The first step of *dependent* activation of [ERK] signaling is Ras binding to members of the Raf family of MAP kinase kinase kinases , C-Raf and B-Raf . Regulation EPHB2 KRAS 9564040 500710 In PKC depleted cells , Ang II increased Ras-GTP level and activated Raf and [ERK] in a *dependent* manner . Regulation EPHB2 KRAS 9632795 513086 These observations suggest that Gab1 acts as an adapter molecule in transmitting signals to ERK MAP kinase for the cytokine receptor gp130 and that SHP-2 , PI-3 kinase , and are *involved* in Gab1 mediated [ERK] activation . Regulation EPHB2 KRAS 9843397 553055 ( c ) [ERK] activation is *independent* of the upstream mediators and Raf-1 . Regulation EPHB2 KSR1 15371409 1334227 is a molecular scaffold that interacts with the components of the Raf/MEK/ERK kinase cascade and positively *regulates* [ERK] signaling . Regulation EPHB2 KSR1 15899786 1408733 These results indicate that mediated *regulation* of [ERK] activity represents a novel determinant of CDDP sensitivity of cancer cells . Regulation EPHB2 KSR1 17056543 1636588 The MAPK scaffold is *involved* in [ERK] activation by stress and proinflammatory cytokines and induction of arthritis . Regulation EPHB2 KSR1 17056543 1636592 Although the scaffold kinase suppressor of Ras (KSR)1 is required for efficient Erk activation by mitogenic stimuli , the *role* of in [ERK] activation by inflammatory and stress stimuli is unknown . Regulation EPHB2 KSR1 17056543 1636593 In this study , we examined the *effects* of deficiency on [ERK] activation by stress stimuli and show that ERK activation by TNF , IL-1 , and sorbitol is attenuated in the absence of KSR1 . Regulation EPHB2 KSR1 17056543 1636594 Thus , *plays* a role in [ERK] activation during inflammatory and stress responses both in vitro and in vivo . Regulation EPHB2 KSR1 21829671 2468262 These simulations constitute a multi-dimensional exploration of how EGF dependent EGFR endocytosis and [ERK] activation are dynamically *affected* by scaffolds and MP1 , co-regulated by Cbl-CIN85 and Endophilin A1 . Regulation EPHB2 KSR1 23221422 2711118 Taken together , these findings indicate that *plays* a dispensable role in LPS induced [ERK] activation in alveolar macrophages and does not contribute to the development of acute lung injury in the LPS model . Regulation EPHB2 LAMTOR3 15923628 1414013 Here we show that the putative scaffold protein and its partner p14 *regulate* PAK1 dependent [ERK] activation during adhesion and cell spreading but are not required for ERK activation by platelet derived growth factor . Regulation EPHB2 LAMTOR3 21829671 2468261 These simulations constitute a multi-dimensional exploration of how EGF dependent EGFR endocytosis and [ERK] activation are dynamically *affected* by scaffolds KSR and , co-regulated by Cbl-CIN85 and Endophilin A1 . Regulation EPHB2 LAT 12817019 1103578 Because TCR activates ERK via SLP-76 mediated activation of the linker of activated T cells (LAT) scaffold protein , we examined the *role* of in SDF-1alpha mediated [ERK] activation . Regulation EPHB2 LAT2 19879355 2184489 *regulates* [ERK] activation in Helicobacter pylori infected epithelial cells . Regulation EPHB2 LCK 22123847 2542192 Instead , Nef triggers *dependent* activation of TGN associated [Ras-Erk] signaling to promote the production of the T lymphocyte survival factor IL-2 and to enhance virus spread . Regulation EPHB2 LCP2 16439309 1516603 Expression of had no discernable *effect* on RA-induced [ERK] activation , subsequent functional differentiation , or the rate of RA-induced G0 arrest . Regulation EPHB2 LEP 16973240 1646993 H2O2 and Src dependent transactivation of the EGF receptor mediates the stimulatory *effect* of on renal [ERK] and Na+ , K+-ATPase . Regulation EPHB2 LEP 16973240 1646999 The *effect* of on [ERK] and Na ( + ) , K ( + ) -ATPase was abolished by catalase , specific inhibitors of epidermal growth factor (EGF) receptor , AG1478 and PD158780 , as well as by ERK inhibitor , PD98059 , and was mimicked by both exogenous H ( 2 ) O ( 2 ) and EGF . Regulation EPHB2 LEP 18206959 1863948 NADPH oxidase inhibitor , apocynin , prevented 's *effect* on BP , [ERK] , Na ( + ) , K ( + ) -ATPase/Na ( + ) excretion and NO formation at all time points . Regulation EPHB2 LPA 12447997 1018231 Accordingly , we show that inhibition of EGFR kinase activity attenuates the *regulated* [ERK] activation . Regulation EPHB2 LPA 12447997 1018235 In addition , we find that the *regulated* tyrosine phosphorylation of EGFR and activation of [ERK] are attenuated by batimastat , a generic inhibitor of matrix metalloproteinases (MMP) . Regulation EPHB2 LPA 15494214 1354852 To further demonstrate the specificity of the phenylephrine and *regulation* of NHE1 and [ERK] , CCL39 cells were transfected with a kinase inactive MEK . Regulation EPHB2 LRP1 10591631 654645 By regulating the uPA/uPAR system , may also *regulate* [ERK] activation , cellular migration , and invasion . Regulation EPHB2 LRP1 20644732 2292491 Moreover , we found that is tethered to the actin network and to focal adhesion sites and *controls* [ERK] and JNK targeting to talin-rich structures . Regulation EPHB2 LRP10 10591631 654642 By regulating the uPA/uPAR system , may also *regulate* [ERK] activation , cellular migration , and invasion . Regulation EPHB2 LRP11 10591631 654643 By regulating the uPA/uPAR system , may also *regulate* [ERK] activation , cellular migration , and invasion . Regulation EPHB2 LRP12 10591631 654644 By regulating the uPA/uPAR system , may also *regulate* [ERK] activation , cellular migration , and invasion . Regulation EPHB2 LRP2 10591631 654646 By regulating the uPA/uPAR system , may also *regulate* [ERK] activation , cellular migration , and invasion . Regulation EPHB2 LRP3 10591631 654647 By regulating the uPA/uPAR system , may also *regulate* [ERK] activation , cellular migration , and invasion . Regulation EPHB2 LRP4 10591631 654648 By regulating the uPA/uPAR system , may also *regulate* [ERK] activation , cellular migration , and invasion . Regulation EPHB2 LRP5 10591631 654649 By regulating the uPA/uPAR system , may also *regulate* [ERK] activation , cellular migration , and invasion . Regulation EPHB2 LRP6 10591631 654650 By regulating the uPA/uPAR system , may also *regulate* [ERK] activation , cellular migration , and invasion . Regulation EPHB2 LRP8 10591631 654651 By regulating the uPA/uPAR system , may also *regulate* [ERK] activation , cellular migration , and invasion . Regulation EPHB2 LRPAP1 12904304 1150330 Preventing activation had no *effect* on BCR induced activation of [ERK] . Regulation EPHB2 MAGI3 16904289 1672821 *regulates* LPA induced activation of [Erk] and RhoA . Regulation EPHB2 MAGI3 20353789 2260867 These data suggest that *regulates* beta2AR mediated [ERK] activation through the physical interaction between beta2AR and MAGI-3 . Regulation EPHB2 MAP2K1 10357882 618456 This was confirmed in the current study by showing that activation of , the upstream *regulator* of [ERK] , reduces Fas mediated apoptosis , whereas inhibition of MEK1 augments apoptosis by Fas . Regulation EPHB2 MAP2K1 10888263 710247 However , PD098059 mediated inhibition of *dependent* stimulation of [ERK] did not alter the hypertrophic response of either agonist . Regulation EPHB2 MAP2K1 11673351 872751 IGF-I-stimulation was followed by a PI3K dependent phosphorylation of AKT and BAD and an *dependent* phosphorylation of extracellular signal regulated kinase ( [ERK] ) 1 and ERK2 . Regulation EPHB2 MAP2K1 11869811 918272 We show that CSD is capable of increasing the phosphorylation of [ERK] in a *dependent* manner . Regulation EPHB2 MAP2K1 12468029 1022521 Increased phospho-ERK immunostaining was dependent on PLC and also on , an upstream *regulator* of [ERK] . Regulation EPHB2 MAP2K1 14563359 1154813 Experiments based on inhibitors of specific signaling pathways , such as manumycin A , toxin A , U0126 , PD98059 and wortmannin revealed that Ras , and PI-3K are *involved* in the activation of [ERK] . Regulation EPHB2 MAP2K1 15750341 1379879 These findings indicate that [ERK] phosphorylation in response to glycated LDL *involves* the activation of PKC , PLC , and , but is independent of intracellular Ca2+ . Regulation EPHB2 MAP2K1 16181409 1461927 The importance of these pathways was further confirmed by the activation of both [ERK] , in a *dependent* manner , and Akt , via PI3K . Regulation EPHB2 MAP2K1 16189274 1507745 In MET positive DLBCL cells , HGF induces *dependent* activation of [ERK] and PI3K dependent phosphorylation of PKB , GSK3 , and FOXO3a . Regulation EPHB2 MAP2K1 16360949 1504586 The phospho-ERK and phospho-MEK profiles were similar , suggesting that [ERK] phosphorylation is *regulated* by . Regulation EPHB2 MAP2K1 17408801 1736027 Changes in [ERK] phosphorylation in IRS-4 depleted cells were *independent* of and PI3K/Akt-cascades . Regulation EPHB2 MAP2K1 18762250 1975633 Additionally , EGFR undergoes *dependent* [ERK] consensus site phosphorylation in response to EGF or cytokines such as growth hormone (GH) and prolactin (PRL) . Regulation EPHB2 MAP2K1 19219045 2044451 Thus , in disagreement with the current perception of the pathway , the *role* of and Mek2 in growth factor induced [Erk] phosphorylation is not interchangeable . Regulation EPHB2 MAP2K1 19342628 2056758 FcgammaRIIIB induced nuclear phosphorylation of [ERK] , and of Elk-1 , was not *affected* by Syk , PI3K , or inhibitors . Regulation EPHB2 MAP2K1 19887597 2299459 aPKC Thr410 phosphorylation and activation also required *dependent* [ERK] ; Regulation EPHB2 MAP2K1 22532442 2631086 Both [ERK] phosphorylation and neuritogenesis were *dependent* ( blocked by 10 µM U0126 ) and PKA independent ( insensitive to 30 µM H-89 or 100 nM myristoylated protein kinase A inhibitor ) . Regulation EPHB2 MAP2K1 22740332 2715452 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Regulation EPHB2 MAP2K1 8034695 264565 The data suggest that is largely *responsible* for the activation of [Erk] in chemoattractant stimulated neutrophils and that protein kinase C and/or tyrosine kinases mediate this effect , whereas elevated cytosolic Ca2+ is not essential . Regulation EPHB2 MAP2K1 8626753 360719 Moreover , NIH 3T3 cells expressing constitutively active MAPK kinase ( , the immediate upstream *regulator* of [ERK] ) were more resistant to H2O2 toxicity , while those expressing kinase-defective MEK were more sensitive , than cells expressing wild-type MEK . Regulation EPHB2 MAP2K2 10888263 710248 However , PD098059 mediated inhibition of *dependent* stimulation of [ERK] did not alter the hypertrophic response of either agonist . Regulation EPHB2 MAP2K2 11869811 918273 We show that CSD is capable of increasing the phosphorylation of [ERK] in a *dependent* manner . Regulation EPHB2 MAP2K2 12468029 1022522 Increased phospho-ERK immunostaining was dependent on PLC and also on , an upstream *regulator* of [ERK] . Regulation EPHB2 MAP2K2 14563359 1154814 Experiments based on inhibitors of specific signaling pathways , such as manumycin A , toxin A , U0126 , PD98059 and wortmannin revealed that Ras , and PI-3K are *involved* in the activation of [ERK] . Regulation EPHB2 MAP2K2 15750341 1379880 These findings indicate that [ERK] phosphorylation in response to glycated LDL *involves* the activation of PKC , PLC , and , but is independent of intracellular Ca2+ . Regulation EPHB2 MAP2K2 16181409 1461928 The importance of these pathways was further confirmed by the activation of both [ERK] , in a *dependent* manner , and Akt , via PI3K . Regulation EPHB2 MAP2K2 16189274 1507746 In MET positive DLBCL cells , HGF induces *dependent* activation of [ERK] and PI3K dependent phosphorylation of PKB , GSK3 , and FOXO3a . Regulation EPHB2 MAP2K2 16360949 1504587 The phospho-ERK and phospho-MEK profiles were similar , suggesting that [ERK] phosphorylation is *regulated* by . Regulation EPHB2 MAP2K2 19219045 2044452 Thus , in disagreement with the current perception of the pathway , the *role* of Mek1 and in growth factor induced [Erk] phosphorylation is not interchangeable . Regulation EPHB2 MAP2K2 19342628 2056759 FcgammaRIIIB induced nuclear phosphorylation of [ERK] , and of Elk-1 , was not *affected* by Syk , PI3K , or inhibitors . Regulation EPHB2 MAP2K2 22532442 2631087 Both [ERK] phosphorylation and neuritogenesis were *dependent* ( blocked by 10 µM U0126 ) and PKA independent ( insensitive to 30 µM H-89 or 100 nM myristoylated protein kinase A inhibitor ) . Regulation EPHB2 MAP2K2 22740332 2715453 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Regulation EPHB2 MAP2K2 8626753 360720 Moreover , NIH 3T3 cells expressing constitutively active MAPK kinase ( , the immediate upstream *regulator* of [ERK] ) were more resistant to H2O2 toxicity , while those expressing kinase-defective MEK were more sensitive , than cells expressing wild-type MEK . Regulation EPHB2 MAP2K3 10888263 710249 However , PD098059 mediated inhibition of *dependent* stimulation of [ERK] did not alter the hypertrophic response of either agonist . Regulation EPHB2 MAP2K3 11869811 918274 We show that CSD is capable of increasing the phosphorylation of [ERK] in a *dependent* manner . Regulation EPHB2 MAP2K3 14563359 1154815 Experiments based on inhibitors of specific signaling pathways , such as manumycin A , toxin A , U0126 , PD98059 and wortmannin revealed that Ras , and PI-3K are *involved* in the activation of [ERK] . Regulation EPHB2 MAP2K3 15750341 1379881 These findings indicate that [ERK] phosphorylation in response to glycated LDL *involves* the activation of PKC , PLC , and , but is independent of intracellular Ca2+ . Regulation EPHB2 MAP2K3 16181409 1461929 The importance of these pathways was further confirmed by the activation of both [ERK] , in a *dependent* manner , and Akt , via PI3K . Regulation EPHB2 MAP2K3 16189274 1507747 In MET positive DLBCL cells , HGF induces *dependent* activation of [ERK] and PI3K dependent phosphorylation of PKB , GSK3 , and FOXO3a . Regulation EPHB2 MAP2K3 16360949 1504588 The phospho-ERK and phospho-MEK profiles were similar , suggesting that [ERK] phosphorylation is *regulated* by . Regulation EPHB2 MAP2K3 19342628 2056760 FcgammaRIIIB induced nuclear phosphorylation of [ERK] , and of Elk-1 , was not *affected* by Syk , PI3K , or inhibitors . Regulation EPHB2 MAP2K3 22532442 2631088 Both [ERK] phosphorylation and neuritogenesis were *dependent* ( blocked by 10 µM U0126 ) and PKA independent ( insensitive to 30 µM H-89 or 100 nM myristoylated protein kinase A inhibitor ) . Regulation EPHB2 MAP2K3 22740332 2715454 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Regulation EPHB2 MAP2K3 8626753 360721 Moreover , NIH 3T3 cells expressing constitutively active MAPK kinase ( , the immediate upstream *regulator* of [ERK] ) were more resistant to H2O2 toxicity , while those expressing kinase-defective MEK were more sensitive , than cells expressing wild-type MEK . Regulation EPHB2 MAP2K4 10888263 710250 However , PD098059 mediated inhibition of *dependent* stimulation of [ERK] did not alter the hypertrophic response of either agonist . Regulation EPHB2 MAP2K4 11869811 918275 We show that CSD is capable of increasing the phosphorylation of [ERK] in a *dependent* manner . Regulation EPHB2 MAP2K4 14563359 1154816 Experiments based on inhibitors of specific signaling pathways , such as manumycin A , toxin A , U0126 , PD98059 and wortmannin revealed that Ras , and PI-3K are *involved* in the activation of [ERK] . Regulation EPHB2 MAP2K4 15750341 1379882 These findings indicate that [ERK] phosphorylation in response to glycated LDL *involves* the activation of PKC , PLC , and , but is independent of intracellular Ca2+ . Regulation EPHB2 MAP2K4 16181409 1461930 The importance of these pathways was further confirmed by the activation of both [ERK] , in a *dependent* manner , and Akt , via PI3K . Regulation EPHB2 MAP2K4 16189274 1507748 In MET positive DLBCL cells , HGF induces *dependent* activation of [ERK] and PI3K dependent phosphorylation of PKB , GSK3 , and FOXO3a . Regulation EPHB2 MAP2K4 16360949 1504589 The phospho-ERK and phospho-MEK profiles were similar , suggesting that [ERK] phosphorylation is *regulated* by . Regulation EPHB2 MAP2K4 19342628 2056761 FcgammaRIIIB induced nuclear phosphorylation of [ERK] , and of Elk-1 , was not *affected* by Syk , PI3K , or inhibitors . Regulation EPHB2 MAP2K4 22532442 2631089 Both [ERK] phosphorylation and neuritogenesis were *dependent* ( blocked by 10 µM U0126 ) and PKA independent ( insensitive to 30 µM H-89 or 100 nM myristoylated protein kinase A inhibitor ) . Regulation EPHB2 MAP2K4 22740332 2715455 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Regulation EPHB2 MAP2K4 8626753 360722 Moreover , NIH 3T3 cells expressing constitutively active MAPK kinase ( , the immediate upstream *regulator* of [ERK] ) were more resistant to H2O2 toxicity , while those expressing kinase-defective MEK were more sensitive , than cells expressing wild-type MEK . Regulation EPHB2 MAP2K5 10888263 710251 However , PD098059 mediated inhibition of *dependent* stimulation of [ERK] did not alter the hypertrophic response of either agonist . Regulation EPHB2 MAP2K5 11869811 918276 We show that CSD is capable of increasing the phosphorylation of [ERK] in a *dependent* manner . Regulation EPHB2 MAP2K5 14563359 1154817 Experiments based on inhibitors of specific signaling pathways , such as manumycin A , toxin A , U0126 , PD98059 and wortmannin revealed that Ras , and PI-3K are *involved* in the activation of [ERK] . Regulation EPHB2 MAP2K5 15750341 1379883 These findings indicate that [ERK] phosphorylation in response to glycated LDL *involves* the activation of PKC , PLC , and , but is independent of intracellular Ca2+ . Regulation EPHB2 MAP2K5 16181409 1461931 The importance of these pathways was further confirmed by the activation of both [ERK] , in a *dependent* manner , and Akt , via PI3K . Regulation EPHB2 MAP2K5 16189274 1507749 In MET positive DLBCL cells , HGF induces *dependent* activation of [ERK] and PI3K dependent phosphorylation of PKB , GSK3 , and FOXO3a . Regulation EPHB2 MAP2K5 16360949 1504590 The phospho-ERK and phospho-MEK profiles were similar , suggesting that [ERK] phosphorylation is *regulated* by . Regulation EPHB2 MAP2K5 19342628 2056762 FcgammaRIIIB induced nuclear phosphorylation of [ERK] , and of Elk-1 , was not *affected* by Syk , PI3K , or inhibitors . Regulation EPHB2 MAP2K5 22532442 2631090 Both [ERK] phosphorylation and neuritogenesis were *dependent* ( blocked by 10 µM U0126 ) and PKA independent ( insensitive to 30 µM H-89 or 100 nM myristoylated protein kinase A inhibitor ) . Regulation EPHB2 MAP2K5 22740332 2715456 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Regulation EPHB2 MAP2K5 8626753 360723 Moreover , NIH 3T3 cells expressing constitutively active MAPK kinase ( , the immediate upstream *regulator* of [ERK] ) were more resistant to H2O2 toxicity , while those expressing kinase-defective MEK were more sensitive , than cells expressing wild-type MEK . Regulation EPHB2 MAP2K6 10888263 710252 However , PD098059 mediated inhibition of *dependent* stimulation of [ERK] did not alter the hypertrophic response of either agonist . Regulation EPHB2 MAP2K6 11869811 918277 We show that CSD is capable of increasing the phosphorylation of [ERK] in a *dependent* manner . Regulation EPHB2 MAP2K6 14563359 1154818 Experiments based on inhibitors of specific signaling pathways , such as manumycin A , toxin A , U0126 , PD98059 and wortmannin revealed that Ras , and PI-3K are *involved* in the activation of [ERK] . Regulation EPHB2 MAP2K6 15750341 1379884 These findings indicate that [ERK] phosphorylation in response to glycated LDL *involves* the activation of PKC , PLC , and , but is independent of intracellular Ca2+ . Regulation EPHB2 MAP2K6 16181409 1461932 The importance of these pathways was further confirmed by the activation of both [ERK] , in a *dependent* manner , and Akt , via PI3K . Regulation EPHB2 MAP2K6 16189274 1507750 In MET positive DLBCL cells , HGF induces *dependent* activation of [ERK] and PI3K dependent phosphorylation of PKB , GSK3 , and FOXO3a . Regulation EPHB2 MAP2K6 16360949 1504591 The phospho-ERK and phospho-MEK profiles were similar , suggesting that [ERK] phosphorylation is *regulated* by . Regulation EPHB2 MAP2K6 19342628 2056763 FcgammaRIIIB induced nuclear phosphorylation of [ERK] , and of Elk-1 , was not *affected* by Syk , PI3K , or inhibitors . Regulation EPHB2 MAP2K6 22532442 2631091 Both [ERK] phosphorylation and neuritogenesis were *dependent* ( blocked by 10 µM U0126 ) and PKA independent ( insensitive to 30 µM H-89 or 100 nM myristoylated protein kinase A inhibitor ) . Regulation EPHB2 MAP2K6 22740332 2715457 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Regulation EPHB2 MAP2K6 8626753 360724 Moreover , NIH 3T3 cells expressing constitutively active MAPK kinase ( , the immediate upstream *regulator* of [ERK] ) were more resistant to H2O2 toxicity , while those expressing kinase-defective MEK were more sensitive , than cells expressing wild-type MEK . Regulation EPHB2 MAP2K7 10888263 710253 However , PD098059 mediated inhibition of *dependent* stimulation of [ERK] did not alter the hypertrophic response of either agonist . Regulation EPHB2 MAP2K7 11560992 862599 Loss of did not *affect* activation of extracellular signal regulated kinase ( [ERK] ) 1/2 or p38 MAPK . Regulation EPHB2 MAP2K7 11869811 918278 We show that CSD is capable of increasing the phosphorylation of [ERK] in a *dependent* manner . Regulation EPHB2 MAP2K7 14563359 1154819 Experiments based on inhibitors of specific signaling pathways , such as manumycin A , toxin A , U0126 , PD98059 and wortmannin revealed that Ras , and PI-3K are *involved* in the activation of [ERK] . Regulation EPHB2 MAP2K7 15750341 1379885 These findings indicate that [ERK] phosphorylation in response to glycated LDL *involves* the activation of PKC , PLC , and , but is independent of intracellular Ca2+ . Regulation EPHB2 MAP2K7 16181409 1461933 The importance of these pathways was further confirmed by the activation of both [ERK] , in a *dependent* manner , and Akt , via PI3K . Regulation EPHB2 MAP2K7 16189274 1507751 In MET positive DLBCL cells , HGF induces *dependent* activation of [ERK] and PI3K dependent phosphorylation of PKB , GSK3 , and FOXO3a . Regulation EPHB2 MAP2K7 16360949 1504592 The phospho-ERK and phospho-MEK profiles were similar , suggesting that [ERK] phosphorylation is *regulated* by . Regulation EPHB2 MAP2K7 19342628 2056764 FcgammaRIIIB induced nuclear phosphorylation of [ERK] , and of Elk-1 , was not *affected* by Syk , PI3K , or inhibitors . Regulation EPHB2 MAP2K7 22532442 2631092 Both [ERK] phosphorylation and neuritogenesis were *dependent* ( blocked by 10 µM U0126 ) and PKA independent ( insensitive to 30 µM H-89 or 100 nM myristoylated protein kinase A inhibitor ) . Regulation EPHB2 MAP2K7 22740332 2715458 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Regulation EPHB2 MAP2K7 8626753 360725 Moreover , NIH 3T3 cells expressing constitutively active MAPK kinase ( , the immediate upstream *regulator* of [ERK] ) were more resistant to H2O2 toxicity , while those expressing kinase-defective MEK were more sensitive , than cells expressing wild-type MEK . Regulation EPHB2 MAP3K11 21965325 2502781 We observed that functions downstream of FGD1 to *regulate* [ERK] and p38 MAPK , which in turn phosphorylate and activate the master regulator of osteoblast differentiation , Runx2 . Regulation EPHB2 MAP3K3 16407301 1527465 *dependent* activation of an NF-kappaB reporter gene as well as [ERK] , JNK , and p38 MAP kinases correlated with a requirement for serine at position 526 . Regulation EPHB2 MAPK1 10207619 606855 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by and MEKs , in turn , are regulated by MAPK kinase kinases (MAPKKKs) . Regulation EPHB2 MAPK1 11713208 880642 In neocortical explants , E2 activates various signaling components of the MAPK cascade , including B-Raf and kinase *dependent* [ERK] , suggesting a possible role in the differentiative actions of E2 in the brain . Regulation EPHB2 MAPK1 12486127 1056332 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [Erk] *regulation* plays a significant role in axon guidance . Regulation EPHB2 MAPK1 15683363 1395421 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [ERK] *regulation* . Regulation EPHB2 MAPK1 16464862 1548101 In contrast , p38 inhibitors had no detectable *effect* on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Regulation EPHB2 MAPK1 19428358 2077030 The time-course analysis of PA accumulation and [ERK-like] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation EPHB2 MAPK1 22371971 2561791 Inhibition of calcineurin further reduced the phosphorylation of [ERK] and AKT ( at thr 308 ) and inhibited the activation of Ras , but inhibitors of or PI3K signaling did not *affect* the circadian rhythm of calcineurin activity . Regulation EPHB2 MAPK10 10207619 606856 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by MAPK/ERK kinases (MEKs) and MEKs , in turn , are regulated by . Regulation EPHB2 MAPK10 11713208 880643 In neocortical explants , E2 activates various signaling components of the MAPK cascade , including B-Raf and kinase *dependent* [ERK] , suggesting a possible role in the differentiative actions of E2 in the brain . Regulation EPHB2 MAPK10 12486127 1056333 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [Erk] *regulation* plays a significant role in axon guidance . Regulation EPHB2 MAPK10 15683363 1395422 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [ERK] *regulation* . Regulation EPHB2 MAPK10 16464862 1548102 In contrast , p38 inhibitors had no detectable *effect* on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Regulation EPHB2 MAPK10 19428358 2077031 The time-course analysis of PA accumulation and [ERK-like] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation EPHB2 MAPK10 22371971 2561792 Inhibition of calcineurin further reduced the phosphorylation of [ERK] and AKT ( at thr 308 ) and inhibited the activation of Ras , but inhibitors of or PI3K signaling did not *affect* the circadian rhythm of calcineurin activity . Regulation EPHB2 MAPK11 10207619 606857 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by MAPK/ERK kinases (MEKs) and MEKs , in turn , are regulated by . Regulation EPHB2 MAPK11 11713208 880644 In neocortical explants , E2 activates various signaling components of the MAPK cascade , including B-Raf and kinase *dependent* [ERK] , suggesting a possible role in the differentiative actions of E2 in the brain . Regulation EPHB2 MAPK11 12486127 1056334 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [Erk] *regulation* plays a significant role in axon guidance . Regulation EPHB2 MAPK11 15683363 1395423 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [ERK] *regulation* . Regulation EPHB2 MAPK11 16464862 1548103 In contrast , p38 inhibitors had no detectable *effect* on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Regulation EPHB2 MAPK11 19428358 2077032 The time-course analysis of PA accumulation and [ERK-like] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation EPHB2 MAPK11 22371971 2561793 Inhibition of calcineurin further reduced the phosphorylation of [ERK] and AKT ( at thr 308 ) and inhibited the activation of Ras , but inhibitors of or PI3K signaling did not *affect* the circadian rhythm of calcineurin activity . Regulation EPHB2 MAPK12 10207619 606858 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by and MEKs , in turn , are regulated by MAPK kinase kinases (MAPKKKs) . Regulation EPHB2 MAPK12 11713208 880645 In neocortical explants , E2 activates various signaling components of the MAPK cascade , including B-Raf and kinase *dependent* [ERK] , suggesting a possible role in the differentiative actions of E2 in the brain . Regulation EPHB2 MAPK12 12486127 1056335 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [Erk] *regulation* plays a significant role in axon guidance . Regulation EPHB2 MAPK12 15683363 1395424 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [ERK] *regulation* . Regulation EPHB2 MAPK12 16464862 1548104 In contrast , p38 inhibitors had no detectable *effect* on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Regulation EPHB2 MAPK12 19428358 2077033 The time-course analysis of PA accumulation and [ERK-like] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation EPHB2 MAPK12 22371971 2561794 Inhibition of calcineurin further reduced the phosphorylation of [ERK] and AKT ( at thr 308 ) and inhibited the activation of Ras , but inhibitors of or PI3K signaling did not *affect* the circadian rhythm of calcineurin activity . Regulation EPHB2 MAPK13 10207619 606859 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by MAPK/ERK kinases (MEKs) and MEKs , in turn , are regulated by . Regulation EPHB2 MAPK13 11713208 880646 In neocortical explants , E2 activates various signaling components of the MAPK cascade , including B-Raf and kinase *dependent* [ERK] , suggesting a possible role in the differentiative actions of E2 in the brain . Regulation EPHB2 MAPK13 12486127 1056336 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [Erk] *regulation* plays a significant role in axon guidance . Regulation EPHB2 MAPK13 15683363 1395425 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [ERK] *regulation* . Regulation EPHB2 MAPK13 16464862 1548105 In contrast , p38 inhibitors had no detectable *effect* on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Regulation EPHB2 MAPK13 19428358 2077034 The time-course analysis of PA accumulation and [ERK-like] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation EPHB2 MAPK13 22371971 2561795 Inhibition of calcineurin further reduced the phosphorylation of [ERK] and AKT ( at thr 308 ) and inhibited the activation of Ras , but inhibitors of or PI3K signaling did not *affect* the circadian rhythm of calcineurin activity . Regulation EPHB2 MAPK14 10207619 606860 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by and MEKs , in turn , are regulated by MAPK kinase kinases (MAPKKKs) . Regulation EPHB2 MAPK14 11713208 880647 In neocortical explants , E2 activates various signaling components of the MAPK cascade , including B-Raf and kinase *dependent* [ERK] , suggesting a possible role in the differentiative actions of E2 in the brain . Regulation EPHB2 MAPK14 12486127 1056337 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [Erk] *regulation* plays a significant role in axon guidance . Regulation EPHB2 MAPK14 12697810 1081438 Interestingly , we show that the *effects* of on [ERK] are restricted to nuclear events . Regulation EPHB2 MAPK14 15683363 1395426 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [ERK] *regulation* . Regulation EPHB2 MAPK14 16464862 1548106 In contrast , p38 inhibitors had no detectable *effect* on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Regulation EPHB2 MAPK14 19428358 2077035 The time-course analysis of PA accumulation and [ERK-like] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation EPHB2 MAPK14 22371971 2561796 Inhibition of calcineurin further reduced the phosphorylation of [ERK] and AKT ( at thr 308 ) and inhibited the activation of Ras , but inhibitors of or PI3K signaling did not *affect* the circadian rhythm of calcineurin activity . Regulation EPHB2 MAPK15 10207619 606854 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by MAPK/ERK kinases (MEKs) and MEKs , in turn , are regulated by . Regulation EPHB2 MAPK15 11713208 880641 In neocortical explants , E2 activates various signaling components of the MAPK cascade , including B-Raf and kinase *dependent* [ERK] , suggesting a possible role in the differentiative actions of E2 in the brain . Regulation EPHB2 MAPK15 12486127 1056331 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [Erk] *regulation* plays a significant role in axon guidance . Regulation EPHB2 MAPK15 15683363 1395420 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [ERK] *regulation* . Regulation EPHB2 MAPK15 16464862 1548099 In contrast , p38 inhibitors had no detectable *effect* on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Regulation EPHB2 MAPK15 19428358 2077029 The time-course analysis of PA accumulation and [ERK-like] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation EPHB2 MAPK15 22371971 2561790 Inhibition of calcineurin further reduced the phosphorylation of [ERK] and AKT ( at thr 308 ) and inhibited the activation of Ras , but inhibitors of or PI3K signaling did not *affect* the circadian rhythm of calcineurin activity . Regulation EPHB2 MAPK3 10207619 606861 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by MAPK/ERK kinases (MEKs) and MEKs , in turn , are regulated by . Regulation EPHB2 MAPK3 11713208 880648 In neocortical explants , E2 activates various signaling components of the MAPK cascade , including B-Raf and kinase *dependent* [ERK] , suggesting a possible role in the differentiative actions of E2 in the brain . Regulation EPHB2 MAPK3 12486127 1056338 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [Erk] *regulation* plays a significant role in axon guidance . Regulation EPHB2 MAPK3 15683363 1395427 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [ERK] *regulation* . Regulation EPHB2 MAPK3 16464862 1548107 In contrast , p38 inhibitors had no detectable *effect* on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Regulation EPHB2 MAPK3 17658892 1776423 Neither the phosphorylation of PEA-15 ( phospho Ser-104 and/or phospho Ser-116 ) nor the phosphorylation of ( by MKK1 ) significantly *affects* the stability of the [ERK/PEA-15] interaction , and therefore it does not directly regulate the release of ERK2 to the nucleus . Regulation EPHB2 MAPK3 19428358 2077036 The time-course analysis of PA accumulation and [ERK-like] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation EPHB2 MAPK3 22371971 2561797 Inhibition of calcineurin further reduced the phosphorylation of [ERK] and AKT ( at thr 308 ) and inhibited the activation of Ras , but inhibitors of or PI3K signaling did not *affect* the circadian rhythm of calcineurin activity . Regulation EPHB2 MAPK4 10207619 606862 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by and MEKs , in turn , are regulated by MAPK kinase kinases (MAPKKKs) . Regulation EPHB2 MAPK4 11713208 880649 In neocortical explants , E2 activates various signaling components of the MAPK cascade , including B-Raf and kinase *dependent* [ERK] , suggesting a possible role in the differentiative actions of E2 in the brain . Regulation EPHB2 MAPK4 12486127 1056339 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [Erk] *regulation* plays a significant role in axon guidance . Regulation EPHB2 MAPK4 15683363 1395428 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [ERK] *regulation* . Regulation EPHB2 MAPK4 16464862 1548108 In contrast , p38 inhibitors had no detectable *effect* on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Regulation EPHB2 MAPK4 19428358 2077037 The time-course analysis of PA accumulation and [ERK-like] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation EPHB2 MAPK4 22371971 2561798 Inhibition of calcineurin further reduced the phosphorylation of [ERK] and AKT ( at thr 308 ) and inhibited the activation of Ras , but inhibitors of or PI3K signaling did not *affect* the circadian rhythm of calcineurin activity . Regulation EPHB2 MAPK6 10207619 606863 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by MAPK/ERK kinases (MEKs) and MEKs , in turn , are regulated by . Regulation EPHB2 MAPK6 11713208 880650 In neocortical explants , E2 activates various signaling components of the MAPK cascade , including B-Raf and kinase *dependent* [ERK] , suggesting a possible role in the differentiative actions of E2 in the brain . Regulation EPHB2 MAPK6 12486127 1056340 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [Erk] *regulation* plays a significant role in axon guidance . Regulation EPHB2 MAPK6 15683363 1395429 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [ERK] *regulation* . Regulation EPHB2 MAPK6 16464862 1548109 In contrast , p38 inhibitors had no detectable *effect* on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Regulation EPHB2 MAPK6 19428358 2077038 The time-course analysis of PA accumulation and [ERK-like] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation EPHB2 MAPK6 22371971 2561799 Inhibition of calcineurin further reduced the phosphorylation of [ERK] and AKT ( at thr 308 ) and inhibited the activation of Ras , but inhibitors of or PI3K signaling did not *affect* the circadian rhythm of calcineurin activity . Regulation EPHB2 MAPK7 10207619 606864 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by MAPK/ERK kinases (MEKs) and MEKs , in turn , are regulated by . Regulation EPHB2 MAPK7 11713208 880651 In neocortical explants , E2 activates various signaling components of the MAPK cascade , including B-Raf and kinase *dependent* [ERK] , suggesting a possible role in the differentiative actions of E2 in the brain . Regulation EPHB2 MAPK7 12486127 1056341 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [Erk] *regulation* plays a significant role in axon guidance . Regulation EPHB2 MAPK7 15683363 1395430 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [ERK] *regulation* . Regulation EPHB2 MAPK7 16464862 1548110 In contrast , p38 inhibitors had no detectable *effect* on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Regulation EPHB2 MAPK7 19428358 2077039 The time-course analysis of PA accumulation and [ERK-like] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation EPHB2 MAPK7 22371971 2561800 Inhibition of calcineurin further reduced the phosphorylation of [ERK] and AKT ( at thr 308 ) and inhibited the activation of Ras , but inhibitors of or PI3K signaling did not *affect* the circadian rhythm of calcineurin activity . Regulation EPHB2 MAPK8 10207619 606865 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by and MEKs , in turn , are regulated by MAPK kinase kinases (MAPKKKs) . Regulation EPHB2 MAPK8 11713208 880652 In neocortical explants , E2 activates various signaling components of the MAPK cascade , including B-Raf and kinase *dependent* [ERK] , suggesting a possible role in the differentiative actions of E2 in the brain . Regulation EPHB2 MAPK8 12486127 1056342 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [Erk] *regulation* plays a significant role in axon guidance . Regulation EPHB2 MAPK8 15683363 1395431 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [ERK] *regulation* . Regulation EPHB2 MAPK8 16464862 1548111 In contrast , p38 inhibitors had no detectable *effect* on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Regulation EPHB2 MAPK8 19428358 2077040 The time-course analysis of PA accumulation and [ERK-like] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation EPHB2 MAPK8 22371971 2561801 Inhibition of calcineurin further reduced the phosphorylation of [ERK] and AKT ( at thr 308 ) and inhibited the activation of Ras , but inhibitors of or PI3K signaling did not *affect* the circadian rhythm of calcineurin activity . Regulation EPHB2 MAPK8IP3 11044439 753388 We next examined the *effect* of overexpressing on the activation of [ERK] by phorbol 12-myristate 13-acetate in transfected COS-7 cells and found that JSAP1 inhibits ERK 's activation and that the COOH-terminal region of JSAP1 was required for the inhibition . Regulation EPHB2 MAPK9 10207619 606866 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein [ERK/MAPKs] are *regulated* by MAPK/ERK kinases (MEKs) and MEKs , in turn , are regulated by . Regulation EPHB2 MAPK9 11713208 880653 In neocortical explants , E2 activates various signaling components of the MAPK cascade , including B-Raf and kinase *dependent* [ERK] , suggesting a possible role in the differentiative actions of E2 in the brain . Regulation EPHB2 MAPK9 12486127 1056343 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [Erk] *regulation* plays a significant role in axon guidance . Regulation EPHB2 MAPK9 15683363 1395432 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [ERK] *regulation* . Regulation EPHB2 MAPK9 16464862 1548112 In contrast , p38 inhibitors had no detectable *effect* on the [ERK] activation induced by fibroblast growth factor 2 or pervanadate , a phosphatase inhibitor , and MEK inhibitors did not influence p38 MAPK phosphorylation , confirming both the specificity and unidirectionality of p38 MAPK-ERK cross-talk . Regulation EPHB2 MAPK9 19428358 2077041 The time-course analysis of PA accumulation and [ERK-like] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation EPHB2 MAPK9 22371971 2561802 Inhibition of calcineurin further reduced the phosphorylation of [ERK] and AKT ( at thr 308 ) and inhibited the activation of Ras , but inhibitors of or PI3K signaling did not *affect* the circadian rhythm of calcineurin activity . Regulation EPHB2 MAPKAP1 20512842 2270584 In this report , we focused on studying the *role* of mTORC1 and in rapamycin mediated Akt and [ERK] phosphorylation , and the antitumor effect of rapamycin in cancer cells in combination with Akt and ERK inhibitors . Regulation EPHB2 MAPKAP1 20512842 2270618 Collectively , we conclude that *plays* a much more important role than mTORC1 in rapamycin mediated phosphorylation of Akt and [ERK] , and cotargeting AKT and ERK signaling may be a new strategy for enhancing the efficacy of rapamycin based therapeutic approaches in cancer cells . Regulation EPHB2 MBTPS1 12443721 1017212 Inhibition of ras with MA and PI3-K with Wn also reduced [ERK] phosphorylation and smooth muscle cell migration in *response* to . Regulation EPHB2 MBTPS1 19433984 2096502 Treatment with the nonselective S1P receptor agonist FTY720 for 1 hour also reduced [phospho-ERK] expression in *response* to subsequent stimulation . Regulation EPHB2 MCL1 16761109 1585443 expression was constitutively elevated in multiple myeloma cell lines , and was not *affected* by [PMA/ERK] or MTDAs . Regulation EPHB2 MDM2 15723837 1396176 [MEK-ERK] signaling *controls* oncoprotein expression by regulating hdm2 mRNA export to the cytoplasm . Regulation EPHB2 MDM2 18070930 1868051 Thus , apart from inhibiting the receptor activity , PPP can induce IGF-1R ubiquitination and stimulate [ERK] in an *dependent* manner . Regulation EPHB2 MIF 18821572 1993593 To understand the *role* of secretion in thrombin induced biphasic activation of [ERK] ( 1/2 ) , BPAE cells were treated with ( i ) recombinant MIF , and ( ii ) the medium collected from thrombin treated BPAE cells . Regulation EPHB2 MIR29A 23529662 2787955 *regulated* the abundance of Wnt signaling components ( Wnt-3a , glycogen synthase kinase 3ß , and ß-catenin ) , the Wnt inhibitor Dkk-1 , Akt , and phosphorylated [ERK] , and the expression of the osteogenic factors RUNX-2 and insulin-like growth factor 1 in bone tissue . Regulation EPHB2 MLST8 20512842 2270585 In this report , we focused on studying the *role* of mTORC1 and in rapamycin mediated Akt and [ERK] phosphorylation , and the antitumor effect of rapamycin in cancer cells in combination with Akt and ERK inhibitors . Regulation EPHB2 MLST8 20512842 2270619 Collectively , we conclude that *plays* a much more important role than mTORC1 in rapamycin mediated phosphorylation of Akt and [ERK] , and cotargeting AKT and ERK signaling may be a new strategy for enhancing the efficacy of rapamycin based therapeutic approaches in cancer cells . Regulation EPHB2 MMP14 14871836 1208308 In addition , expression of the hemopexin-like domain of MT1-MMP in HT1080 cells interfered with MMP-2 processing , ERK activation , and cell migration , implying that the enzymatic activity of is *involved* in collagen induced [ERK] activation , which results in enhanced cell migration . Regulation EPHB2 MMP14 16473349 1548317 ( MT1-MMP ) *plays* an important role in extracellular matrix induced cell migration and the activation of extracellular signal regulated kinase ( [ERK] ) . Regulation EPHB2 MMP7 22089237 2514190 We show that elevated levels of and a disintegrin and metalloproteinase-12 ( ADAM12 ) in a ( 1a ) -247R expressing cells are *responsible* for EGF receptor (EGFR) transactivation , downstream [ERK] activation , and increased cell proliferation ; Regulation EPHB2 MRE11A 11228165 788450 is *involved* in cell stretching modulation of p38 but not [ERK] or JNK MAP kinase . Regulation EPHB2 MRE11A 11479306 860727 The *role* of in [ERK] and Akt activity was further demonstrated by our observation that an active form of Epac , which activated Rap1 in the absence of cAMP , increased ERK and Akt phosphorylation . Regulation EPHB2 MRE11A 14551200 1175559 Experiments involving the expression of the dominant negative mutants of Ras and Rap1 signaling ( RasN17 or Rap1N17 ) indicate that both GTPases Ras and Rap1 are recruited for the ERK activation by VIP and PACAP38 , whereas is poorly *involved* in TRH or EGF induced [ERK] activation . Regulation EPHB2 MRE11A 15278365 1277265 In confluent NHK , cyclic AMP decreased [extracellular regulated kinase (ERK)] phosphorylation and cell proliferation in a Ras independent and *dependent* manner . Regulation EPHB2 MSTN 24606069 2933886 Finally , we found that activin-A and activate Smad-2/3 signaling but do not *affect* [ERK] or p38 signaling in both myometrial and leiomyoma cells . Regulation EPHB2 MTA1 23683282 2785499 Furthermore , phosphorylation of [ERK] and JNK in *response* to was inhibited when the medium was supplemented with nifedipine . Regulation EPHB2 MTA2 23683282 2785500 Furthermore , phosphorylation of [ERK] and JNK in *response* to was inhibited when the medium was supplemented with nifedipine . Regulation EPHB2 MTA3 23683282 2785498 Furthermore , phosphorylation of [ERK] and JNK in *response* to was inhibited when the medium was supplemented with nifedipine . Regulation EPHB2 MTOR 20512842 2270588 In this report , we focused on studying the *role* of and mTORC2 in rapamycin mediated Akt and [ERK] phosphorylation , and the antitumor effect of rapamycin in cancer cells in combination with Akt and ERK inhibitors . Regulation EPHB2 MTOR 20512842 2270621 Collectively , we conclude that *plays* a much more important role than mTORC1 in rapamycin mediated phosphorylation of Akt and [ERK] , and cotargeting AKT and ERK signaling may be a new strategy for enhancing the efficacy of rapamycin based therapeutic approaches in cancer cells . Regulation EPHB2 MUC4 16891313 1614514 An analysis of the *effects* of expression on [ERK] phosphorylation in mammary tumor and epithelial cells , which exhibit both adhesion dependent growth and contact inhibition of growth , showed that the effects are density dependent , with opposing effects on proliferating cells and contact inhibited cells . Regulation EPHB2 MYD88 16951362 1610469 Our investigations revealed that immunocompetent TLR2 , TLR4 , and knockout mice were not more susceptible to invasive aspergillosis as compared with wild-type mice and that the in vitro phosphorylation of the MAPKs [ERK] and p38 was not *affected* in TLR2 , TLR4 , or MyD88 knockout mice following stimulation with conidia . Regulation EPHB2 MYD88 21881005 2510433 Basolateral LPS inhibits NHE3 and HCOFormula absorption through *dependent* [ERK] activation in medullary thick ascending limb . Regulation EPHB2 MYD88 22634720 2675867 Furthermore , we demonstrated that *dependent* [p38/ERK] activation is critical to TLR2 mediated T-cell IFN-? release following EtOH and burn injury . Regulation EPHB2 MYLIP 23835497 2854256 Luciferase reporter assays confirmed that binds and *regulates* EphB1 and [EphB2] mRNAs . Regulation EPHB2 MYLIP 24803541 2950602 [EphB2] contributes to human naive B-cell activation and is *regulated* by . Regulation EPHB2 MYLIP 24803541 2950604 Our study first suggested that [EphB2] was involved in human naive B cell activation through Src-p65 and Notch1 signaling pathways and could be *regulated* by . Regulation EPHB2 NA 15965078 1423459 We investigated whether H2O2 , superoxide , and [ERK] participate in nerve growth factor (NGF) induced signaling cascades and whether antioxidant *regulates* these NGF induced responses . Regulation EPHB2 NEDD9 16980301 1640382 Taken together , these results suggest that phosphorylation by GRK5 and binding of arrestin-2 negatively *regulates* LPS stimulated [ERK] activation . Regulation EPHB2 NF1 18984165 1983662 *regulation* of [ERK] signaling modulates GABA release and learning . Regulation EPHB2 NFKB1 15100369 1239794 mRNA expression of MCP-1 was abolished by inhibition , but were not *affected* by the inhibition of [ERK] , JNK , or p38 . Regulation EPHB2 NFKB1 16283237 1484083 ERK activity is required for NFkappaB mediated transcription of Nos2 in insulin producing INS-1E cells , indicating that [ERK] *regulates* Nos2 expression by increasing the transactivating capacity of . Regulation EPHB2 NFKB1 20558745 2302501 rHSP90alpha induced the activities of [ERK] , PI3K/Akt , and NF-kappaB p65 , but only activation was *involved* in HSP90alpha induced integrin alpha(V) expression . Regulation EPHB2 NGB 23478801 2771808 Mutation of Ngb at its oxygen binding site ( H64L ) abolished the inhibitory *effects* of on [Erk] activation and HepG2 cell proliferation . Regulation EPHB2 NGF 10470855 641410 The activation of [Erk] kinase activity in *response* to was sustained longer in the Rsu-1 transfectants compared with the vector control cells . Regulation EPHB2 NGF 10585878 571588 However , PP2 inhibited [ERK] activation in response to NE and UTP , but not in *response* to EGF or . Regulation EPHB2 NGF 10891597 711267 The distinct *regulation* of [ERK] by ANG II and further indicates basic differences in AT(2) receptor- and NGF induced neuronal differentiation . Regulation EPHB2 NGF 15005709 1217456 Introduction of a kinase-defective mutant of BREK into PC12 cells enhanced both [ERK] phosphorylation and neurite outgrowth in *response* to , suggesting that BREK is a negative regulator of NGF induced neuronal differentiation . Regulation EPHB2 NGF 22065583 2516984 To characterize the transcriptional program activated preferentially by NGF , we compared global gene expression profiles between cells treated with NGF and EGF for 2-4 h , when sustained [ERK] signaling in *response* to is most distinct from the transient signal elicited by EGF . Regulation EPHB2 NGF 7865752 287239 Differential *effect* of and EGF on [ERK] in neuronally differentiated PC12 cells . Regulation EPHB2 NMS 18649147 2020021 Western blot analysis revealed significant *effect* on [p-ERK] expression in the lumbosacral dorsal horn and thalamus . Regulation EPHB2 NMS 18649147 2020022 Significant *effect* on [p-ERK] and c-fos expression was observed in the DRG , and laminae I-II , III-IV , and X of the lumbosacral dorsal horn . Regulation EPHB2 NMS 18649147 2020024 Furthermore , a significant interactive *effect* of and CRD on [p-ERK] expression was observed in laminae III-IV of the lumbosacral dorsal horn . Regulation EPHB2 NOX4 24095877 2867695 In vitro , Ang II suppressed RECK expression in adult mouse cardiac fibroblasts ( CF ) via *dependent* [ERK/Sp1] activation , but induced MMPs 2 , 14 and 9 via NF-?B , AP-1 and/or Sp1 activation . Regulation EPHB2 NPY4R 21518335 2567465 The Phase II ( 5-10 min ) rapid decline in [ERK] phosphorylation *involves* PKA inhibition and serine/threonine phosphatase activation . Regulation EPHB2 NPY6R 10666504 665613 The major aim of the present study was to examine the mechanism of decrease in ERK activity by adrenomedullin and to identify the *role* of protein in the decrease in [ERK] activity , using okadaic acid [ 9,10-Deepithio-9,10-didehydroacanthifolicin ] , a selective inhibitor of PP2A at low nanomolar concentrations . Regulation EPHB2 NPY6R 17875324 1843358 Interestingly , however , had no significant *effect* on the activation of NF-kappaB , or on p42/44 [ERK] , p46/54 JNK or p38 MAPK phosphorylation . Regulation EPHB2 NRAS 10749883 698495 These data clearly demonstrate that the alpha-thrombin induced activation coordinately *regulates* [ERK] and PI 3-kinase activities , both of which are required for expression of cyclin D1 protein and progression through G ( 1 ) . Regulation EPHB2 NRAS 10976990 729644 In contrast to their implication in epidermal growth factor (EGF) receptor tyrosine kinase signaling , the adaptor protein Shc , the Grb2/Sos complex , and the small G protein were not *involved* in the activation of [Erk] induced by either LPA or PGF2alpha in MC3T3-E1 cells , suggesting that activation of Erk by Gi and Gq protein coupled receptors is Ras independent in these cells . Regulation EPHB2 NRAS 11269657 797348 Arsenite inhibits *dependent* activation of [ERK] but activates ERK in the presence of oncogenic Ras in baboon vascular smooth muscle cells . Regulation EPHB2 NRAS 11278310 810925 In contrast , inhibition of or Src had no *effect* on the sustained [ERK] activity , which was critically dependent on phosphatidylinositol 3-kinase . Regulation EPHB2 NRAS 11791173 901790 Here we determined the efficacy of Shc and N-Shc toward Erk activation in NGF treated PC12 cells , and found that N-Shc transduced *dependent* [Erk] activation less efficiently than Shc . Regulation EPHB2 NRAS 12082537 958588 In exponentially growing cells , oncogenic had no *effect* on proliferation rates , [Erk] phosphorylation , or the level of cyclin D1 , and Ras-induction did not confer serum independent growth . Regulation EPHB2 NRAS 12193071 981006 Thus , p38 MAP kinase stimulation could perhaps partially account for ET-1 contractive properties , whereas ET-1 induced cell proliferation occurs primarily via *dependent* activation of the [ERK] . Regulation EPHB2 NRAS 12855697 1134969 This unresponsiveness is associated with the constitutive activation of the small G protein , Rap1 , and the lack of *dependent* activation of [ERK] . Regulation EPHB2 NRAS 12902324 1150293 Co-expression of DN-TRAF6 and N17Ras completely inhibited CpG DNA induced COX2-3'-UTR-luciferase activity , indicating the *involvement* of in CpG DNA mediated [ERK] and COX2-3'-UTR regulation . Regulation EPHB2 NRAS 15029245 1228118 Developmentally regulated *role* for in coupling NMDA glutamate receptors to Ras , [Erk] and CREB . Regulation EPHB2 NRAS 16214133 1468869 In addition , transfection of ES cells with DN-Src , or DN-Ras partially inhibited 8-Br-cAMP induced ERK1/2 and consequently PLD activation , whereas cotransfection of DN-Src and DN-Ras completely inhibited ERK1/2 and PLD activation , suggesting that Src and independently *regulate* [ERK/PLD] activation . Regulation EPHB2 NRAS 16709153 1598867 However , a biochemical link between PE and GAP inactivation is missing and GEF stimulation is hard to reconcile with the observation that dominant negative S17N-Ras does not compromise *dependent* [ERK] ( extracellular-signal regulated kinase ) activation by PE . Regulation EPHB2 NRAS 17000055 1647268 Post-ischemia reperfusion resulted in the phosphorylation of [ERK] in a *dependent* manner ; Regulation EPHB2 NRAS 17045653 1666551 In the present study , we investigated the *role* of in FLG- and LPS mediated signaling in [ERK] activation in chicken heterophils . Regulation EPHB2 NRAS 17174095 1688105 Kinase Suppressor of Ras (KSR) is a molecular scaffold that interacts with the core kinase components of the ERK cascade , Raf , MEK , and ERK and provides spatial and temporal regulation of *dependent* [ERK] cascade signaling . Regulation EPHB2 NRAS 17873330 1796090 The aim of this work is to evaluate if can be induced by TSH in rat thyroids , and whether [extracellular regulated kinase (ERK)] may be *involved* in the subsequent intracellular signalling cascade . Regulation EPHB2 NRAS 19015044 2035061 Under basal conditions , EGFR activated [ERK] in a classical *dependent* manner . Regulation EPHB2 NRAS 21678474 2483654 Furthermore , we demonstrate the mechanism for PLD1 activation of [ERK] *involves* . Regulation EPHB2 NRAS 23363700 2747755 is greatly *involved* in determining and regulating directionality , [ERK] is its key effector for starting , driving and regulating directional movement . Regulation EPHB2 NRAS 23893412 2839583 The first step of *dependent* activation of [ERK] signaling is Ras binding to members of the Raf family of MAP kinase kinase kinases , C-Raf and B-Raf . Regulation EPHB2 NRAS 9564040 500711 In PKC depleted cells , Ang II increased Ras-GTP level and activated Raf and [ERK] in a *dependent* manner . Regulation EPHB2 NRAS 9632795 513087 These observations suggest that Gab1 acts as an adapter molecule in transmitting signals to ERK MAP kinase for the cytokine receptor gp130 and that SHP-2 , PI-3 kinase , and are *involved* in Gab1 mediated [ERK] activation . Regulation EPHB2 NRAS 9843397 553056 ( c ) [ERK] activation is *independent* of the upstream mediators and Raf-1 . Regulation EPHB2 NRG1 22496574 2583688 These changes are associated with rapid membrane expansion yielding a 35-50 % increase in SC size within 30 min. Cofilin1-deficient SCs increase phosphorylation of ErbB2 , [ERK] , focal adhesion kinase , and paxillin in *response* to , but fail to increase in size possibly due to stabilization of unusually long focal adhesions . Regulation EPHB2 P2RX3 16616417 1569012 Thus , it is suggested that the activation of the receptor is *involved* in the phosphorylation of [ERK] in DRG neurons and the mechanical hypersensitivity of the inflamed knee joint . Regulation EPHB2 P2RX7 15075366 1251806 We observed that the P2X7 agonists adenosine 5'-triphosphate ( ATP ) and 3'-O- ( 4-benzoylbenzoyl ) ATP ( BzATP ) stimulated actin reorganization and concomitant membrane blebbing within 5 min. Disruption of actin filaments with cytochalasin D attenuated membrane blebbing but not *dependent* pore formation or [extracellular regulated kinase (ERK)1/ERK2] and p38 activation , suggesting that these latter processes do not require intact actin filaments . Regulation EPHB2 PAK1 12511425 1070775 PAK1 ( p21 activated kinase 1 ) activation is induced by C albicans , suggesting that may also be *involved* in the Rac1 activation of [MAPK/ERK] . Regulation EPHB2 PAK1 17429073 1742484 [Erk] in lipopolysaccharide (LPS) treated mouse lung is activated in a *dependent* manner in several cell types , most prominently vascular endothelium . Regulation EPHB2 PAK2 17429073 1742485 [Erk] in lipopolysaccharide (LPS) treated mouse lung is activated in a *dependent* manner in several cell types , most prominently vascular endothelium . Regulation EPHB2 PAK3 17429073 1742486 [Erk] in lipopolysaccharide (LPS) treated mouse lung is activated in a *dependent* manner in several cell types , most prominently vascular endothelium . Regulation EPHB2 PAK4 17429073 1742482 [Erk] in lipopolysaccharide (LPS) treated mouse lung is activated in a *dependent* manner in several cell types , most prominently vascular endothelium . Regulation EPHB2 PAK6 17429073 1742483 [Erk] in lipopolysaccharide (LPS) treated mouse lung is activated in a *dependent* manner in several cell types , most prominently vascular endothelium . Regulation EPHB2 PAK7 17429073 1742481 [Erk] in lipopolysaccharide (LPS) treated mouse lung is activated in a *dependent* manner in several cell types , most prominently vascular endothelium . Regulation EPHB2 PAM 17458858 1743189 Conversely , [ERK] activation in *response* to the TLR2 agonist is completely MyD88 dependent and unaffected by Syk deficiency . Regulation EPHB2 PARP1 11228165 788448 is *involved* in cell stretching modulation of p38 but not [ERK] or JNK MAP kinase . Regulation EPHB2 PARP1 11479306 860725 The *role* of in [ERK] and Akt activity was further demonstrated by our observation that an active form of Epac , which activated Rap1 in the absence of cAMP , increased ERK and Akt phosphorylation . Regulation EPHB2 PARP1 14551200 1175557 Experiments involving the expression of the dominant negative mutants of Ras and Rap1 signaling ( RasN17 or Rap1N17 ) indicate that both GTPases Ras and Rap1 are recruited for the ERK activation by VIP and PACAP38 , whereas is poorly *involved* in TRH or EGF induced [ERK] activation . Regulation EPHB2 PARP1 15278365 1277263 In confluent NHK , cyclic AMP decreased [extracellular regulated kinase (ERK)] phosphorylation and cell proliferation in a Ras independent and *dependent* manner . Regulation EPHB2 PDCD1 18077057 1861990 and differential JNK , p38 and [ERK] *response* in a prenatal acute hypoxic hypoxia model . Regulation EPHB2 PDCD10 18077057 1861991 and differential JNK , p38 and [ERK] *response* in a prenatal acute hypoxic hypoxia model . Regulation EPHB2 PDCD11 18077057 1861989 and differential JNK , p38 and [ERK] *response* in a prenatal acute hypoxic hypoxia model . Regulation EPHB2 PDCD2 18077057 1861992 and differential JNK , p38 and [ERK] *response* in a prenatal acute hypoxic hypoxia model . Regulation EPHB2 PDCD4 18077057 1861993 and differential JNK , p38 and [ERK] *response* in a prenatal acute hypoxic hypoxia model . Regulation EPHB2 PDCD5 18077057 1861994 and differential JNK , p38 and [ERK] *response* in a prenatal acute hypoxic hypoxia model . Regulation EPHB2 PDCD6 18077057 1861995 and differential JNK , p38 and [ERK] *response* in a prenatal acute hypoxic hypoxia model . Regulation EPHB2 PDCD7 18077057 1861996 and differential JNK , p38 and [ERK] *response* in a prenatal acute hypoxic hypoxia model . Regulation EPHB2 PDGFB 15753096 1396971 This was accompanied by rapid uptake of receptor bound PDGF-BB into the cells and by attenuated [ERK] activation in *response* to stimulation . Regulation EPHB2 PDGFB 19106095 2031539 Reducing the MKP3 level by small interfering RNA leads to an increased [Erk] activation and mitogenic *response* to . Regulation EPHB2 PDGFB 22972916 2719961 Blockade of cAMP-PKA pathway reversed the inhibitory effect of CTRP9 on DNA synthesis and [ERK] phosphorylation in *response* to . Regulation EPHB2 PDK4 21852536 2468836 Overexpression of ErbB2 maintains PDH flux by suppressing expression in an Erk dependent manner , and [Erk] signaling also *regulates* PDH flux in ECM attached cells . Regulation EPHB2 PDLIM7 22417000 2606576 These findings indicate the existence of a new cell cycle associated signaling pathway in which *regulates* [ERK] mediated Op18/stathmin signaling . Regulation EPHB2 PEA15 10926929 743807 The common *involvement* of and PLD in apoptosis , [ERK] activation , and glucose transport additionally suggests functional significance . Regulation EPHB2 PEA15 17658892 1776424 Neither the phosphorylation of ( phospho Ser-104 and/or phospho Ser-116 ) nor the phosphorylation of ERK1/2 ( by MKK1 ) significantly *affects* the stability of the [ERK/PEA-15] interaction , and therefore it does not directly regulate the release of ERK2 to the nucleus . Regulation EPHB2 PEA15 17700518 1865981 *regulates* the level of phosphorylated [extracellular regulated kinase (ERK)1/2] in glioblastoma cells and the PEA-15 dependent protection from glucose deprivation induced cell death requires ERK1/2 signaling . Regulation EPHB2 PEA15 22105357 2629390 Our findings reveal a novel mechanism by which positively *regulates* [Ras/ERK] signaling and increases the proliferation of H-Ras transformed epithelial cells through enhanced PLD1 expression and activation . Regulation EPHB2 PEBP1 17000055 1647271 We propose that , following ischemia , the Src family tyrosine kinases are critical for modulation of the Ras/Raf/MEK/ERK cascade , in which is *involved* in biphasic phosphorylation of [ERK] via a blockade of Src-Raf cascades . Regulation EPHB2 PEBP1 17370424 1713651 Analytical solutions , relating the steady-state values of the fast varying protein concentrations and the slow varying ones , are derived and interpreted as restrictions on the regulatory *role* of on [ERK-pathway] . Regulation EPHB2 PEBP1 22492043 2583523 Collectively , our data reveal an important *role* of in the regulation of [MAPK/ERK] signaling in the SCN and photic entrainment of the SCN clock . Regulation EPHB2 PEBP1 23814485 2808253 Through several molecular biologic analyses , we found that , an inhibitor of Raf kinase , is *responsible* for p53 mediated [ERK] suppression and senescence . Regulation EPHB2 PF4 12384403 998646 To exclude the possibility that PF-4 inhibited the binding of FGF2 to only one FGF receptor , preferentially activating the ERK pathway , we investigated the *effect* of on FGF2 induced [ERK] and Akt phosphorylation , using mutant heparan sulfate-deficient Chinese hamster ovary cells transfected with the FGF-R1 cDNA . Regulation EPHB2 PGC 20955697 2407036 Overexpression of decreased both basal and PDGF induced p38 MAPK phosphorylation , but it had no *effect* on [ERK] phosphorylation . Regulation EPHB2 PGF 20124327 2202450 These findings suggest that aging does not affect the ability of the rat aorta to activate [ERK] ( 1/2 ) - , p38-MAPK , and JNK-MAPK phosphorylation in *response* to stimulation . Regulation EPHB2 PHKA2 11311138 804906 Phosphorylation of [ERK] ( extracellular-signal regulated protein kinase ) was not *affected* by overexpression of kinase negative . Regulation EPHB2 PHKA2 11851354 913224 *Role* of EGF Receptor and in endothelin-1 induced [ERK] activation in rat cardiomyocytes . Regulation EPHB2 PI3 10688975 670364 Thus , these data suggest that activation of [ERK] by calcitonin gene related peptide *involves* a H89-sensitive protein kinase A and a wortmannin-sensitive while activation of p38 MAPK by calcitonin gene related peptide involves only the H89 sensitive pathway and is independent of PI3 kinase . Regulation EPHB2 PI3 10958675 724916 Unexpectedly , a CSF-1R lacking the PI3-kinase binding site ( DeltaKI ) remained capable of activating [MEK/ERK] in a *dependent* manner . Regulation EPHB2 PI3 11818455 908214 The WKYMVm induced [ERK] activation was *dependent* but PKC independent . Regulation EPHB2 PI3 11931654 927554 We found that binding of both types of integrin to their natural ligands activated [ERK] in a Syk- and *dependent* manner . Regulation EPHB2 PI3 12444151 1017344 These data suggest that , in M-CSF stimulated human monocytes , products and ROS production *play* a role in [Erk] activation and monocyte survival . Regulation EPHB2 PI3 12502866 1033862 Examination of viral DNA entry suggests a *role* for in HHV-8 entry into the target cells and a role for PKC-zeta , MEK , and [ERK] at a post-viral entry stage of infection . Regulation EPHB2 PI3 12736339 1087505 To examine this hypothesis , we investigated the *effects* of inhibitors on [ERK] activation and LTP induction in the CA1 region of mouse hippocampal slices . Regulation EPHB2 PI3 14563359 1154820 Experiments based on inhibitors of specific signaling pathways , such as manumycin A , toxin A , U0126 , PD98059 and wortmannin revealed that Ras , MEK and are *involved* in the activation of [ERK] . Regulation EPHB2 PI3 14996702 1257045 In mast cells and other more committed hematopoietic precursors , the activation of [Erk] by SF is not kinase *dependent* . Regulation EPHB2 PI3 20971723 2376071 Gb3 accumulation reduces K ( Ca ) 3.1 channel expression by down *regulating* [ERK] and AP-1 and up-regulating REST and the channel activity by decreasing intracellular levels of . Regulation EPHB2 PIK3C3 11483663 844506 Inhibition of protein kinase C ( PKC ) and had little *effect* on Zn2+ induced [ERK] activation . Regulation EPHB2 PIK3C3 12871951 1142302 *dependent* activation of renal mesangial cell Ki-Ras and [ERK] by advanced glycation end products . Regulation EPHB2 PIK3CA 10495776 647139 The pathway leading to peroxisome proliferator induced ERK activation is different than that induced by phorbol ester or EGF , since the inhibitors had no *effect* on [ERK] phosphorylation induced by these agents . Regulation EPHB2 PIK3CA 10669726 665956 Finally , IGF mediated degradation of IRS-1 was blocked by inhibition of activity but was not *affected* by inhibition of [ERK] , suggesting that this may represent a direct negative-feedback mechanism resulting from downstream IRS-1 signaling . Regulation EPHB2 PIK3CA 11027277 738764 and endocytosis may also *regulate* [ERK] signaling at a second site downstream of Ras , since both rapid ERK activation and the Ras dependent activation of the MAP kinase kinase kinase B-Raf are blocked by inhibition of either PI3-K or endocytosis . Regulation EPHB2 PIK3CA 11211919 763859 These results suggest that the formation of F-actin is dependent on PI3-K and independent of PKC , ERK and p38 MAPK as well as the increase in intracellular Ca2+ , whereas the activation of NADPH oxidase is partly dependent on [ERK] , p38 MAPK , Akt *regulated* by , and strongly dependent on the activation of PKC and the increase in intracellular Ca2+ . Regulation EPHB2 PIK3CA 11673351 872752 IGF-I-stimulation was followed by a *dependent* phosphorylation of AKT and BAD and an MEK1 dependent phosphorylation of extracellular signal regulated kinase ( [ERK] ) 1 and ERK2 . Regulation EPHB2 PIK3CA 12054657 951333 In addition , we have investigated the *involvement* of in the MAPKs and [ERK] and JNK phosphorylation , in the presence or absence of Btk . Regulation EPHB2 PIK3CA 15337530 1291376 We have characterized the *role* of Drosophila and AKT in [ERK] pathway activation involving insulin induced proliferation using Drosophila Schneider cells . Regulation EPHB2 PIK3CA 15344880 1292085 To study the *role* of in insulin stimulation of [ERK] , we employed PI3K inhibitor LY294002 and mouse embryonic R- fibroblasts lacking IGF-1 receptors . Regulation EPHB2 PIK3CA 16133873 1450282 inhibitor , LY294002 , reduced IGF-I stimulated phosphorylation of FKHR , FKHRL1 , and Akt , but did not *affect* [Erk] phosphorylation . Regulation EPHB2 PIK3CA 16339552 1491639 A *role* for in TCR stimulated [ERK] activation leading to paxillin phosphorylation and CTL degranulation . Regulation EPHB2 PIK3CA 16339552 1491647 These studies demonstrate that *regulates* [ERK] activity leading to CTL degranulation , and identify paxillin as a target of ERK downstream of the TCR . Regulation EPHB2 PIK3CA 16514107 1671813 Our findings demonstrate that Reelin triggers ERK signaling in an SFK/mDab1- and *dependent* manner and that [ERK] activation is required for Reelin dependent transcriptional activation and the detachment of neurons migrating from the SVZ . Regulation EPHB2 PIK3CA 17408801 1736028 Changes in [ERK] phosphorylation in IRS-4 depleted cells were *independent* of ras/raf/MEK1/2- and . Regulation EPHB2 PIK3CA 18958173 1982862 In TSC2 ( -/- ) ASM cells specific inhibitors ( e.g. LY294002 , wortmannin ) and Akt1 siRNA had little *effect* on S6 and [ERK] phosphorylation . Regulation EPHB2 PIK3CA 19186178 2054117 Interestingly , activation of signaling had differential *effects* on [ERK] and p38 activation . Regulation EPHB2 PIK3CA 19342628 2056765 FcgammaRIIIB induced nuclear phosphorylation of [ERK] , and of Elk-1 , was not *affected* by Syk , , or MEK inhibitors . Regulation EPHB2 PIK3CA 20441566 2274835 In the present study , we evaluated the *role* of specific isoforms alpha , beta , gamma and delta in platelet aggregation , thromboxane A2 generation and [ERK] ( extracellular-signal regulated kinase ) activation . Regulation EPHB2 PIK3CA 20924651 2364672 The aim of this study is to determine whether depletion of *affects* [ERK] or PKB/Akt activity following stimulation with serum and insulin growth factors in Chinese hamster ovary cells expressing human insulin receptors ( CHO-IR ) and human HepG2 liver cells . Regulation EPHB2 PIK3CA 21199670 2391594 In addition , PTTH stimulated ERK phosphorylation of the prothoracic glands was not inhibited by either LY294002 or wortmannin , indicating that is not *involved* in PTTH stimulated [ERK] signaling . Regulation EPHB2 PIK3CA 22371971 2561803 Inhibition of calcineurin further reduced the phosphorylation of [ERK] and AKT ( at thr 308 ) and inhibited the activation of Ras , but inhibitors of MAPK or signaling did not *affect* the circadian rhythm of calcineurin activity . Regulation EPHB2 PIK3CA 23143475 2751886 We also found that the extracellular signal regulated kinase ( ERK ) signaling pathway was activated in a *dependent* manner upon FceRI stimulation and that simultaneous inhibition of Akt and [ERK] resulted in nearly complete blockade of FceRI induced degranulation . Regulation EPHB2 PIK3CA 23872471 2835330 The basal [phospho-ERK] level increased gradually throughout a 5-day culture period and was *dependent* as demonstrated by its sensitivity to Wortmannin suggesting it is influenced by growth factors . Regulation EPHB2 PIK3CA 24327733 2880344 *regulates* [MEK/ERK] signaling in breast cancer via the Rac-GEF , P-Rex1 . Regulation EPHB2 PIK3CA 7498528 335888 The results of this study show that in hepatic stellate cells is *involved* in [ERK] activation , although it is not necessary . Regulation EPHB2 PIK3R1 10495776 647140 The pathway leading to peroxisome proliferator induced ERK activation is different than that induced by phorbol ester or EGF , since the inhibitors had no *effect* on [ERK] phosphorylation induced by these agents . Regulation EPHB2 PIK3R1 10669726 665957 Finally , IGF mediated degradation of IRS-1 was blocked by inhibition of activity but was not *affected* by inhibition of [ERK] , suggesting that this may represent a direct negative-feedback mechanism resulting from downstream IRS-1 signaling . Regulation EPHB2 PIK3R1 11027277 738765 and endocytosis may also *regulate* [ERK] signaling at a second site downstream of Ras , since both rapid ERK activation and the Ras dependent activation of the MAP kinase kinase kinase B-Raf are blocked by inhibition of either PI3-K or endocytosis . Regulation EPHB2 PIK3R1 11211919 763860 These results suggest that the formation of F-actin is dependent on PI3-K and independent of PKC , ERK and p38 MAPK as well as the increase in intracellular Ca2+ , whereas the activation of NADPH oxidase is partly dependent on [ERK] , p38 MAPK , Akt *regulated* by , and strongly dependent on the activation of PKC and the increase in intracellular Ca2+ . Regulation EPHB2 PIK3R1 11673351 872753 IGF-I-stimulation was followed by a *dependent* phosphorylation of AKT and BAD and an MEK1 dependent phosphorylation of extracellular signal regulated kinase ( [ERK] ) 1 and ERK2 . Regulation EPHB2 PIK3R1 12054657 951334 In addition , we have investigated the *involvement* of in the MAPKs and [ERK] and JNK phosphorylation , in the presence or absence of Btk . Regulation EPHB2 PIK3R1 15337530 1291377 We have characterized the *role* of Drosophila and AKT in [ERK] pathway activation involving insulin induced proliferation using Drosophila Schneider cells . Regulation EPHB2 PIK3R1 15344880 1292086 To study the *role* of in insulin stimulation of [ERK] , we employed PI3K inhibitor LY294002 and mouse embryonic R- fibroblasts lacking IGF-1 receptors . Regulation EPHB2 PIK3R1 16133873 1450283 inhibitor , LY294002 , reduced IGF-I stimulated phosphorylation of FKHR , FKHRL1 , and Akt , but did not *affect* [Erk] phosphorylation . Regulation EPHB2 PIK3R1 16339552 1491640 A *role* for in TCR stimulated [ERK] activation leading to paxillin phosphorylation and CTL degranulation . Regulation EPHB2 PIK3R1 16339552 1491648 These studies demonstrate that *regulates* [ERK] activity leading to CTL degranulation , and identify paxillin as a target of ERK downstream of the TCR . Regulation EPHB2 PIK3R1 16514107 1671814 Our findings demonstrate that Reelin triggers [ERK] signaling in an SFK/mDab1- and *dependent* manner and that ERK activation is required for Reelin dependent transcriptional activation and the detachment of neurons migrating from the SVZ . Regulation EPHB2 PIK3R1 17408801 1736029 Changes in [ERK] phosphorylation in IRS-4 depleted cells were *independent* of ras/raf/MEK1/2- and . Regulation EPHB2 PIK3R1 18958173 1982863 In TSC2 ( -/- ) ASM cells specific inhibitors ( e.g. LY294002 , wortmannin ) and Akt1 siRNA had little *effect* on S6 and [ERK] phosphorylation . Regulation EPHB2 PIK3R1 19186178 2054118 Interestingly , activation of signaling had differential *effects* on [ERK] and p38 activation . Regulation EPHB2 PIK3R1 19342628 2056766 FcgammaRIIIB induced nuclear phosphorylation of [ERK] , and of Elk-1 , was not *affected* by Syk , , or MEK inhibitors . Regulation EPHB2 PIK3R1 20441566 2274836 In the present study , we evaluated the *role* of specific isoforms alpha , beta , gamma and delta in platelet aggregation , thromboxane A2 generation and [ERK] ( extracellular-signal regulated kinase ) activation . Regulation EPHB2 PIK3R1 20924651 2364673 The aim of this study is to determine whether depletion of *affects* [ERK] or PKB/Akt activity following stimulation with serum and insulin growth factors in Chinese hamster ovary cells expressing human insulin receptors ( CHO-IR ) and human HepG2 liver cells . Regulation EPHB2 PIK3R1 21199670 2391595 In addition , PTTH stimulated ERK phosphorylation of the prothoracic glands was not inhibited by either LY294002 or wortmannin , indicating that is not *involved* in PTTH stimulated [ERK] signaling . Regulation EPHB2 PIK3R1 22371971 2561804 Inhibition of calcineurin further reduced the phosphorylation of [ERK] and AKT ( at thr 308 ) and inhibited the activation of Ras , but inhibitors of MAPK or signaling did not *affect* the circadian rhythm of calcineurin activity . Regulation EPHB2 PIK3R1 23143475 2751887 We also found that the extracellular signal regulated kinase ( ERK ) signaling pathway was activated in a *dependent* manner upon FceRI stimulation and that simultaneous inhibition of Akt and [ERK] resulted in nearly complete blockade of FceRI induced degranulation . Regulation EPHB2 PIK3R1 23872471 2835331 The basal [phospho-ERK] level increased gradually throughout a 5-day culture period and was *dependent* as demonstrated by its sensitivity to Wortmannin suggesting it is influenced by growth factors . Regulation EPHB2 PIK3R1 24327733 2880345 *regulates* [MEK/ERK] signaling in breast cancer via the Rac-GEF , P-Rex1 . Regulation EPHB2 PIK3R1 7498528 335889 The results of this study show that in hepatic stellate cells is *involved* in [ERK] activation , although it is not necessary . Regulation EPHB2 PIK3R4 11483663 844507 Inhibition of protein kinase C ( PKC ) and had little *effect* on Zn2+ induced [ERK] activation . Regulation EPHB2 PIK3R4 12871951 1142303 *dependent* activation of renal mesangial cell Ki-Ras and [ERK] by advanced glycation end products . Regulation EPHB2 PITX2 18977218 1995152 This data supports the *role* of proteins on [ERK] activation in human atherosclerosis which identifies RGS proteins as new therapeutical targets . Regulation EPHB2 PKD1 24709100 2931772 [ERK] *regulates* the export of SphK2 and apoptosis of HCT116 cells by modulating . Regulation EPHB2 PKD2 24709100 2931773 [ERK] *regulates* the export of SphK2 and apoptosis of HCT116 cells by modulating . Regulation EPHB2 PKD3 24709100 2931774 [ERK] *regulates* the export of SphK2 and apoptosis of HCT116 cells by modulating . Regulation EPHB2 PLAU 12426305 1036644 however , these cells demonstrated [ERK] activation in *response* to , indicating the presence of an EGFR independent alternative pathway . Regulation EPHB2 PLAU 12426305 1036646 When CHO-K1 cells were transfected to express EGFR or a kinase-inactive mutant of EGFR , [ERK] activation in *response* to was unchanged ; Regulation EPHB2 PLAU 15728176 1396243 In this study , we demonstrate that [ERK] activation in *response* to follows equivalent biphasic kinetics in EGFR expressing and -deficient CHO-K1 cells . Regulation EPHB2 PLAUR 11266465 796887 The kinetics of [ERK] phosphorylation in *response* to ligation determine the function of uPA and uPA-PAI-1 complex as growth promoters . Regulation EPHB2 PLAUR 21896743 2487035 Here , we show that does not *regulate* [ERK] activation in EGFRvIII expressing GBM cells ; Regulation EPHB2 PLD1 10926929 743808 The common *involvement* of PEA-15 and in apoptosis , [ERK] activation , and glucose transport additionally suggests functional significance . Regulation EPHB2 PLD1 12149127 997558 The *roles* of and PLD2 in [ERK] activation and IL-8 secretion activated by S1P were investigated by infecting cells with adenoviral constructs of wild-type and catalytically inactive mutants of PLD1 and PLD2 . Regulation EPHB2 PLD1 12890486 1117338 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Regulation EPHB2 PLD1 15355882 1353876 Collectively , these data indicate that ET-1 is a potent mitogenic factor in ELT-3 cells via a signaling pathway involving a *dependent* activation of [ERK] . Regulation EPHB2 PLD1 22481092 2601566 We investigated the *role* of activity on paxillin regulation , [Erk] activation and formation of a paxillin-Erk and paxillin-FAK association . Regulation EPHB2 PLD1 24164897 2889691 While inhibition of both and DGK had no *effect* on the overall [ERK] activity , inhibition of PLD2 but not PLD1 or DGK blocked the nuclear ERK activity in several cancer cell lines . Regulation EPHB2 PLD2 10926929 743809 The common *involvement* of PEA-15 and in apoptosis , [ERK] activation , and glucose transport additionally suggests functional significance . Regulation EPHB2 PLD2 11682141 874013 Taken together , we suggest that activity might *play* a negative role in ATP induced [ERK] phosphorylation and mitogenic signal possibly through phosphatases . Regulation EPHB2 PLD2 12149127 997559 The *roles* of PLD1 and in [ERK] activation and IL-8 secretion activated by S1P were investigated by infecting cells with adenoviral constructs of wild-type and catalytically inactive mutants of PLD1 and PLD2 . Regulation EPHB2 PLD2 12890486 1117339 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Regulation EPHB2 PLD2 14704231 1225435 Localization of VEGFR-2 and in endothelial caveolae is *involved* in VEGF induced phosphorylation of MEK and [ERK] . Regulation EPHB2 PLD2 15355882 1353877 Collectively , these data indicate that ET-1 is a potent mitogenic factor in ELT-3 cells via a signaling pathway involving a *dependent* activation of [ERK] . Regulation EPHB2 PLD2 22481092 2601567 We investigated the *role* of activity on paxillin regulation , [Erk] activation and formation of a paxillin-Erk and paxillin-FAK association . Regulation EPHB2 PLD2 24164897 2889692 While inhibition of both and DGK had no *effect* on the overall [ERK] activity , inhibition of PLD2 but not PLD1 or DGK blocked the nuclear ERK activity in several cancer cell lines . Regulation EPHB2 PLD3 10926929 743803 The common *involvement* of PEA-15 and in apoptosis , [ERK] activation , and glucose transport additionally suggests functional significance . Regulation EPHB2 PLD3 12890486 1117334 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Regulation EPHB2 PLD3 15355882 1353872 Collectively , these data indicate that ET-1 is a potent mitogenic factor in ELT-3 cells via a signaling pathway involving a *dependent* activation of [ERK] . Regulation EPHB2 PLD3 22481092 2601562 We investigated the *role* of activity on paxillin regulation , [Erk] activation and formation of a paxillin-Erk and paxillin-FAK association . Regulation EPHB2 PLD3 24164897 2889687 While inhibition of both and DGK had no *effect* on the overall [ERK] activity , inhibition of PLD2 but not PLD1 or DGK blocked the nuclear ERK activity in several cancer cell lines . Regulation EPHB2 PLD4 10926929 743804 The common *involvement* of PEA-15 and in apoptosis , [ERK] activation , and glucose transport additionally suggests functional significance . Regulation EPHB2 PLD4 12890486 1117335 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Regulation EPHB2 PLD4 15355882 1353873 Collectively , these data indicate that ET-1 is a potent mitogenic factor in ELT-3 cells via a signaling pathway involving a *dependent* activation of [ERK] . Regulation EPHB2 PLD4 22481092 2601563 We investigated the *role* of activity on paxillin regulation , [Erk] activation and formation of a paxillin-Erk and paxillin-FAK association . Regulation EPHB2 PLD4 24164897 2889688 While inhibition of both and DGK had no *effect* on the overall [ERK] activity , inhibition of PLD2 but not PLD1 or DGK blocked the nuclear ERK activity in several cancer cell lines . Regulation EPHB2 PLD5 10926929 743805 The common *involvement* of PEA-15 and in apoptosis , [ERK] activation , and glucose transport additionally suggests functional significance . Regulation EPHB2 PLD5 12890486 1117336 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Regulation EPHB2 PLD5 15355882 1353874 Collectively , these data indicate that ET-1 is a potent mitogenic factor in ELT-3 cells via a signaling pathway involving a *dependent* activation of [ERK] . Regulation EPHB2 PLD5 22481092 2601564 We investigated the *role* of activity on paxillin regulation , [Erk] activation and formation of a paxillin-Erk and paxillin-FAK association . Regulation EPHB2 PLD5 24164897 2889689 While inhibition of both and DGK had no *effect* on the overall [ERK] activity , inhibition of PLD2 but not PLD1 or DGK blocked the nuclear ERK activity in several cancer cell lines . Regulation EPHB2 PLD6 10926929 743806 The common *involvement* of PEA-15 and in apoptosis , [ERK] activation , and glucose transport additionally suggests functional significance . Regulation EPHB2 PLD6 12890486 1117337 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Regulation EPHB2 PLD6 15355882 1353875 Collectively , these data indicate that ET-1 is a potent mitogenic factor in ELT-3 cells via a signaling pathway involving a *dependent* activation of [ERK] . Regulation EPHB2 PLD6 22481092 2601565 We investigated the *role* of activity on paxillin regulation , [Erk] activation and formation of a paxillin-Erk and paxillin-FAK association . Regulation EPHB2 PLD6 24164897 2889690 While inhibition of both and DGK had no *effect* on the overall [ERK] activity , inhibition of PLD2 but not PLD1 or DGK blocked the nuclear ERK activity in several cancer cell lines . Regulation EPHB2 POLDIP2 16210341 1507848 Thus , *plays* an important role in mediating PKG dependent activation of [ERK] . Regulation EPHB2 POT1 20877310 2381763 Moreover , we found that negatively *regulated* GNDF induced [ERK] activation and neurite outgrowth . Regulation EPHB2 POT1 24523415 2924202 Moreover , our results showed that NMDA mediated activation of the small G-protein Ras is necessary for PI3K/Akt pathway activation , whereas was *involved* in NMDA phosphorylation of [ERK] . Regulation EPHB2 PPARG 17065204 1700348 These results are consistent with three pathways through which glitazones may act in effecting metabolic processes ( ammoniagenesis and gluconeogenesis ) as well as cellular growth : 1 ) *dependent* and PPAR-gamma independent pathways , 2 ) [P-ERK] activation , and 3 ) mitochondrial AMPK activation . Regulation EPHB2 PPARG 19900469 2271984 Among them , [ERK] can be positively/negatively *regulated* by ligands , as in endothelial cells , where TZDs exert anti-inflammatory effects through a novel mechanism involving a rapid inhibition of ERK1/2 phosphorylation/activation . Regulation EPHB2 PPARGC1A 17987121 1821453 Mechanistic study demonstrated that the *effects* of on VSMC proliferation and migration result from its capacity to prevent [ERK] phosphorylation . Regulation EPHB2 PPP2CA 10666504 665618 Okadaic acid completely reversed the ERK inhibition caused by adrenomedullin , suggesting that may be *involved* in the adrenomedullin mediated changes in proliferation , apoptosis and [ERK] activity . Regulation EPHB2 PPP2CA 12937125 1132901 In vitro , these tau phospho-epitopes can be phosphorylated by the kinases [ERK] and JNK , and the kinases themselves are negatively *regulated* by . Regulation EPHB2 PPP2CA 16477370 1548486 Thus , *regulates* the [ERK] activity in a cell-specific manner , and it is speculated that distinct regulation of PP2A in the ErbB4 receptor signalling pathway may cause a difference in progression of cancer phenotypes . Regulation EPHB2 PPP2CA 18155662 1855214 We found that *regulates* alphaIIbbeta3 control of the [ERK] signaling in a polymorphism specific fashion . Regulation EPHB2 PPP2CA 18272021 1911637 Accordingly , *regulates* acute dose- and time dependent changes in [MEK-ERK-p90RSK] phosphorylation after haloperidol treatment . Regulation EPHB2 PPP2CA 21518335 2567462 The Phase II ( 5-10 min ) rapid decline in [ERK] phosphorylation *involves* PKA inhibition and serine/threonine phosphatase activation . Regulation EPHB2 PPP2R1A 10666504 665619 Okadaic acid completely reversed the ERK inhibition caused by adrenomedullin , suggesting that may be *involved* in the adrenomedullin mediated changes in proliferation , apoptosis and [ERK] activity . Regulation EPHB2 PPP2R1A 12937125 1132902 In vitro , these tau phospho-epitopes can be phosphorylated by the kinases [ERK] and JNK , and the kinases themselves are negatively *regulated* by . Regulation EPHB2 PPP2R1A 16477370 1548487 Thus , *regulates* the [ERK] activity in a cell-specific manner , and it is speculated that distinct regulation of PP2A in the ErbB4 receptor signalling pathway may cause a difference in progression of cancer phenotypes . Regulation EPHB2 PPP2R1A 18155662 1855215 We found that *regulates* alphaIIbbeta3 control of the [ERK] signaling in a polymorphism specific fashion . Regulation EPHB2 PPP2R1A 18272021 1911638 Accordingly , *regulates* acute dose- and time dependent changes in [MEK-ERK-p90RSK] phosphorylation after haloperidol treatment . Regulation EPHB2 PPP2R1A 21518335 2567463 The Phase II ( 5-10 min ) rapid decline in [ERK] phosphorylation *involves* PKA inhibition and serine/threonine phosphatase activation . Regulation EPHB2 PPP2R2B 10666504 665620 Okadaic acid completely reversed the ERK inhibition caused by adrenomedullin , suggesting that may be *involved* in the adrenomedullin mediated changes in proliferation , apoptosis and [ERK] activity . Regulation EPHB2 PPP2R2B 12937125 1132903 In vitro , these tau phospho-epitopes can be phosphorylated by the kinases [ERK] and JNK , and the kinases themselves are negatively *regulated* by . Regulation EPHB2 PPP2R2B 16477370 1548488 Thus , *regulates* the [ERK] activity in a cell-specific manner , and it is speculated that distinct regulation of PP2A in the ErbB4 receptor signalling pathway may cause a difference in progression of cancer phenotypes . Regulation EPHB2 PPP2R2B 18155662 1855216 We found that *regulates* alphaIIbbeta3 control of the [ERK] signaling in a polymorphism specific fashion . Regulation EPHB2 PPP2R2B 18272021 1911639 Accordingly , *regulates* acute dose- and time dependent changes in [MEK-ERK-p90RSK] phosphorylation after haloperidol treatment . Regulation EPHB2 PPP2R2B 21518335 2567464 The Phase II ( 5-10 min ) rapid decline in [ERK] phosphorylation *involves* PKA inhibition and serine/threonine phosphatase activation . Regulation EPHB2 PPP3CA 18956431 1995053 Stretch induced activation of [ERK] in myocytes is p38 and *dependent* . Regulation EPHB2 PPP3CA 24243530 2903222 *Participation* of and CaMKII in [ERK] phosphorylation was discounted . Regulation EPHB2 PPP3R1 18956431 1995054 Stretch induced activation of [ERK] in myocytes is p38 and *dependent* . Regulation EPHB2 PPP3R1 24243530 2903223 *Participation* of and CaMKII in [ERK] phosphorylation was discounted . Regulation EPHB2 PRDX2 25049740 2886705 The *effect* of on [ERK] phosphorylation ( p-ERK1/2 ) in cumulus cells and GDF9 protein level in fully grown oocytes ( FGOs ) were detected by Western blotting . Regulation EPHB2 PREX1 24327733 2880343 PI3K *regulates* [MEK/ERK] signaling in breast cancer via the Rac-GEF , . Regulation EPHB2 PRKACB 10652372 663156 Thus , we further show that , in both PC12 cells and hippocampal neurons , depolarization induced calcium influx stimulates [ERK] activity in a *dependent* manner . Regulation EPHB2 PRKACB 12676735 1076816 Isoproterenol increased phosphorylation of [ERK] in a *dependent* manner , and inhibition of the ERK phosphorylation prevented the stimulation of H-K-ATPase . Regulation EPHB2 PRKACB 16452469 1540595 Pharmacological inhibition of cAMP dependent protein kinase (PKA) and siRNA mediated depletion of PKA greatly reduced B-Raf activity , ERK1/2 activation , and cell proliferation in ( WT ) B-Raf cells , whereas it did not affect ( V600E ) B-Raf cells , demonstrating a key *role* of in mediating ( WT ) [B-Raf/ERK] signaling for uveal melanoma cell growth . Regulation EPHB2 PRKACB 16887887 1632408 Galpha ( s ) *dependent* [ERK] activation was rapid , transient , and blocked by H89 ( a PKA inhibitor ) , but it was insensitive to small interfering RNA mediated depletion of beta-arrestins . Regulation EPHB2 PRKACB 20015475 2200040 Prostaglandin E2 activates cAMP response element binding protein in glioma cells via a signaling pathway involving *dependent* inhibition of [ERK] . Regulation EPHB2 PRKACB 20808799 2314297 We here studied , in the gold-standard non-human primate model of Parkinson 's disease , the changes in *dependent* phosphorylation of DARPP-32 and GluR1 AMPA receptor , as well as in [ERK] and ribosomal protein S6 ( S6 ) phosphorylation , associated to acute and chronic administration of L-DOPA . Regulation EPHB2 PRKACB 21518335 2567466 The Phase II ( 5-10 min ) rapid decline in [ERK] phosphorylation *involves* inhibition and serine/threonine phosphatase PP1/PP2A activation . Regulation EPHB2 PRKACB 22981806 2697869 H89 , a selective inhibitor of cyclic AMP dependent protein kinase A (PKA) , inhibited the NPFF activated ERK pathway , indicating the *involvement* of in the NPFF induced [ERK] activation . Regulation EPHB2 PRKACB 24842369 2940248 In vivo imaging reveals *regulation* of [ERK] activity during neutrophil recruitment to inflamed intestines . Regulation EPHB2 PRKACB 9892211 586632 We have studied the *effects* of EGF , IGF-I , and the activator forskolin on the activation of p42/ extracellular signal regulated kinase ( [ERK] ) 2 , which is a key kinase in mediation of growth factor induced mitogenesis in prostate cancer cells . Regulation EPHB2 PRKACG 10652372 663157 Thus , we further show that , in both PC12 cells and hippocampal neurons , depolarization induced calcium influx stimulates [ERK] activity in a *dependent* manner . Regulation EPHB2 PRKACG 12676735 1076817 Isoproterenol increased phosphorylation of [ERK] in a *dependent* manner , and inhibition of the ERK phosphorylation prevented the stimulation of H-K-ATPase . Regulation EPHB2 PRKACG 16452469 1540596 Pharmacological inhibition of cAMP dependent protein kinase (PKA) and siRNA mediated depletion of PKA greatly reduced B-Raf activity , ERK1/2 activation , and cell proliferation in ( WT ) B-Raf cells , whereas it did not affect ( V600E ) B-Raf cells , demonstrating a key *role* of in mediating ( WT ) [B-Raf/ERK] signaling for uveal melanoma cell growth . Regulation EPHB2 PRKACG 16887887 1632409 Galpha ( s ) *dependent* [ERK] activation was rapid , transient , and blocked by H89 ( a PKA inhibitor ) , but it was insensitive to small interfering RNA mediated depletion of beta-arrestins . Regulation EPHB2 PRKACG 20015475 2200041 Prostaglandin E2 activates cAMP response element binding protein in glioma cells via a signaling pathway involving *dependent* inhibition of [ERK] . Regulation EPHB2 PRKACG 20808799 2314298 We here studied , in the gold-standard non-human primate model of Parkinson 's disease , the changes in *dependent* phosphorylation of DARPP-32 and GluR1 AMPA receptor , as well as in [ERK] and ribosomal protein S6 ( S6 ) phosphorylation , associated to acute and chronic administration of L-DOPA . Regulation EPHB2 PRKACG 21518335 2567467 The Phase II ( 5-10 min ) rapid decline in [ERK] phosphorylation *involves* inhibition and serine/threonine phosphatase PP1/PP2A activation . Regulation EPHB2 PRKACG 22981806 2697870 H89 , a selective inhibitor of cyclic AMP dependent protein kinase A (PKA) , inhibited the NPFF activated ERK pathway , indicating the *involvement* of in the NPFF induced [ERK] activation . Regulation EPHB2 PRKACG 24842369 2940249 In vivo imaging reveals *regulation* of [ERK] activity during neutrophil recruitment to inflamed intestines . Regulation EPHB2 PRKACG 9892211 586633 We have studied the *effects* of EGF , IGF-I , and the activator forskolin on the activation of p42/ extracellular signal regulated kinase ( [ERK] ) 2 , which is a key kinase in mediation of growth factor induced mitogenesis in prostate cancer cells . Regulation EPHB2 PRKAR1A 10652372 663158 Thus , we further show that , in both PC12 cells and hippocampal neurons , depolarization induced calcium influx stimulates [ERK] activity in a *dependent* manner . Regulation EPHB2 PRKAR1A 12676735 1076818 Isoproterenol increased phosphorylation of [ERK] in a *dependent* manner , and inhibition of the ERK phosphorylation prevented the stimulation of H-K-ATPase . Regulation EPHB2 PRKAR1A 16452469 1540597 Pharmacological inhibition of cAMP dependent protein kinase (PKA) and siRNA mediated depletion of PKA greatly reduced B-Raf activity , ERK1/2 activation , and cell proliferation in ( WT ) B-Raf cells , whereas it did not affect ( V600E ) B-Raf cells , demonstrating a key *role* of in mediating ( WT ) [B-Raf/ERK] signaling for uveal melanoma cell growth . Regulation EPHB2 PRKAR1A 16887887 1632410 Galpha ( s ) *dependent* [ERK] activation was rapid , transient , and blocked by H89 ( a PKA inhibitor ) , but it was insensitive to small interfering RNA mediated depletion of beta-arrestins . Regulation EPHB2 PRKAR1A 20015475 2200042 Prostaglandin E2 activates cAMP response element binding protein in glioma cells via a signaling pathway involving *dependent* inhibition of [ERK] . Regulation EPHB2 PRKAR1A 20808799 2314299 We here studied , in the gold-standard non-human primate model of Parkinson 's disease , the changes in *dependent* phosphorylation of DARPP-32 and GluR1 AMPA receptor , as well as in [ERK] and ribosomal protein S6 ( S6 ) phosphorylation , associated to acute and chronic administration of L-DOPA . Regulation EPHB2 PRKAR1A 21518335 2567468 The Phase II ( 5-10 min ) rapid decline in [ERK] phosphorylation *involves* inhibition and serine/threonine phosphatase PP1/PP2A activation . Regulation EPHB2 PRKAR1A 22981806 2697871 H89 , a selective inhibitor of cyclic AMP dependent protein kinase A (PKA) , inhibited the NPFF activated ERK pathway , indicating the *involvement* of in the NPFF induced [ERK] activation . Regulation EPHB2 PRKAR1A 24842369 2940250 In vivo imaging reveals *regulation* of [ERK] activity during neutrophil recruitment to inflamed intestines . Regulation EPHB2 PRKAR1A 9892211 586634 We have studied the *effects* of EGF , IGF-I , and the activator forskolin on the activation of p42/ extracellular signal regulated kinase ( [ERK] ) 2 , which is a key kinase in mediation of growth factor induced mitogenesis in prostate cancer cells . Regulation EPHB2 PRKAR1B 10652372 663159 Thus , we further show that , in both PC12 cells and hippocampal neurons , depolarization induced calcium influx stimulates [ERK] activity in a *dependent* manner . Regulation EPHB2 PRKAR1B 12676735 1076819 Isoproterenol increased phosphorylation of [ERK] in a *dependent* manner , and inhibition of the ERK phosphorylation prevented the stimulation of H-K-ATPase . Regulation EPHB2 PRKAR1B 16452469 1540598 Pharmacological inhibition of cAMP dependent protein kinase (PKA) and siRNA mediated depletion of PKA greatly reduced B-Raf activity , ERK1/2 activation , and cell proliferation in ( WT ) B-Raf cells , whereas it did not affect ( V600E ) B-Raf cells , demonstrating a key *role* of in mediating ( WT ) [B-Raf/ERK] signaling for uveal melanoma cell growth . Regulation EPHB2 PRKAR1B 16887887 1632411 Galpha ( s ) *dependent* [ERK] activation was rapid , transient , and blocked by H89 ( a PKA inhibitor ) , but it was insensitive to small interfering RNA mediated depletion of beta-arrestins . Regulation EPHB2 PRKAR1B 20015475 2200043 Prostaglandin E2 activates cAMP response element binding protein in glioma cells via a signaling pathway involving *dependent* inhibition of [ERK] . Regulation EPHB2 PRKAR1B 20808799 2314300 We here studied , in the gold-standard non-human primate model of Parkinson 's disease , the changes in *dependent* phosphorylation of DARPP-32 and GluR1 AMPA receptor , as well as in [ERK] and ribosomal protein S6 ( S6 ) phosphorylation , associated to acute and chronic administration of L-DOPA . Regulation EPHB2 PRKAR1B 21518335 2567469 The Phase II ( 5-10 min ) rapid decline in [ERK] phosphorylation *involves* inhibition and serine/threonine phosphatase PP1/PP2A activation . Regulation EPHB2 PRKAR1B 22981806 2697872 H89 , a selective inhibitor of cyclic AMP dependent protein kinase A (PKA) , inhibited the NPFF activated ERK pathway , indicating the *involvement* of in the NPFF induced [ERK] activation . Regulation EPHB2 PRKAR1B 24842369 2940251 In vivo imaging reveals *regulation* of [ERK] activity during neutrophil recruitment to inflamed intestines . Regulation EPHB2 PRKAR1B 9892211 586635 We have studied the *effects* of EGF , IGF-I , and the activator forskolin on the activation of p42/ extracellular signal regulated kinase ( [ERK] ) 2 , which is a key kinase in mediation of growth factor induced mitogenesis in prostate cancer cells . Regulation EPHB2 PRKAR2A 10652372 663160 Thus , we further show that , in both PC12 cells and hippocampal neurons , depolarization induced calcium influx stimulates [ERK] activity in a *dependent* manner . Regulation EPHB2 PRKAR2A 12676735 1076820 Isoproterenol increased phosphorylation of [ERK] in a *dependent* manner , and inhibition of the ERK phosphorylation prevented the stimulation of H-K-ATPase . Regulation EPHB2 PRKAR2A 16452469 1540599 Pharmacological inhibition of cAMP dependent protein kinase (PKA) and siRNA mediated depletion of PKA greatly reduced B-Raf activity , ERK1/2 activation , and cell proliferation in ( WT ) B-Raf cells , whereas it did not affect ( V600E ) B-Raf cells , demonstrating a key *role* of in mediating ( WT ) [B-Raf/ERK] signaling for uveal melanoma cell growth . Regulation EPHB2 PRKAR2A 16887887 1632412 Galpha ( s ) *dependent* [ERK] activation was rapid , transient , and blocked by H89 ( a PKA inhibitor ) , but it was insensitive to small interfering RNA mediated depletion of beta-arrestins . Regulation EPHB2 PRKAR2A 20015475 2200044 Prostaglandin E2 activates cAMP response element binding protein in glioma cells via a signaling pathway involving *dependent* inhibition of [ERK] . Regulation EPHB2 PRKAR2A 20808799 2314301 We here studied , in the gold-standard non-human primate model of Parkinson 's disease , the changes in *dependent* phosphorylation of DARPP-32 and GluR1 AMPA receptor , as well as in [ERK] and ribosomal protein S6 ( S6 ) phosphorylation , associated to acute and chronic administration of L-DOPA . Regulation EPHB2 PRKAR2A 21518335 2567470 The Phase II ( 5-10 min ) rapid decline in [ERK] phosphorylation *involves* inhibition and serine/threonine phosphatase PP1/PP2A activation . Regulation EPHB2 PRKAR2A 22981806 2697873 H89 , a selective inhibitor of cyclic AMP dependent protein kinase A (PKA) , inhibited the NPFF activated ERK pathway , indicating the *involvement* of in the NPFF induced [ERK] activation . Regulation EPHB2 PRKAR2A 24842369 2940252 In vivo imaging reveals *regulation* of [ERK] activity during neutrophil recruitment to inflamed intestines . Regulation EPHB2 PRKAR2A 9892211 586636 We have studied the *effects* of EGF , IGF-I , and the activator forskolin on the activation of p42/ extracellular signal regulated kinase ( [ERK] ) 2 , which is a key kinase in mediation of growth factor induced mitogenesis in prostate cancer cells . Regulation EPHB2 PRKAR2B 10652372 663161 Thus , we further show that , in both PC12 cells and hippocampal neurons , depolarization induced calcium influx stimulates [ERK] activity in a *dependent* manner . Regulation EPHB2 PRKAR2B 12676735 1076821 Isoproterenol increased phosphorylation of [ERK] in a *dependent* manner , and inhibition of the ERK phosphorylation prevented the stimulation of H-K-ATPase . Regulation EPHB2 PRKAR2B 16452469 1540600 Pharmacological inhibition of cAMP dependent protein kinase (PKA) and siRNA mediated depletion of PKA greatly reduced B-Raf activity , ERK1/2 activation , and cell proliferation in ( WT ) B-Raf cells , whereas it did not affect ( V600E ) B-Raf cells , demonstrating a key *role* of in mediating ( WT ) [B-Raf/ERK] signaling for uveal melanoma cell growth . Regulation EPHB2 PRKAR2B 16887887 1632413 Galpha ( s ) *dependent* [ERK] activation was rapid , transient , and blocked by H89 ( a PKA inhibitor ) , but it was insensitive to small interfering RNA mediated depletion of beta-arrestins . Regulation EPHB2 PRKAR2B 20015475 2200045 Prostaglandin E2 activates cAMP response element binding protein in glioma cells via a signaling pathway involving *dependent* inhibition of [ERK] . Regulation EPHB2 PRKAR2B 20808799 2314302 We here studied , in the gold-standard non-human primate model of Parkinson 's disease , the changes in *dependent* phosphorylation of DARPP-32 and GluR1 AMPA receptor , as well as in [ERK] and ribosomal protein S6 ( S6 ) phosphorylation , associated to acute and chronic administration of L-DOPA . Regulation EPHB2 PRKAR2B 21518335 2567471 The Phase II ( 5-10 min ) rapid decline in [ERK] phosphorylation *involves* inhibition and serine/threonine phosphatase PP1/PP2A activation . Regulation EPHB2 PRKAR2B 22981806 2697874 H89 , a selective inhibitor of cyclic AMP dependent protein kinase A (PKA) , inhibited the NPFF activated ERK pathway , indicating the *involvement* of in the NPFF induced [ERK] activation . Regulation EPHB2 PRKAR2B 24842369 2940253 In vivo imaging reveals *regulation* of [ERK] activity during neutrophil recruitment to inflamed intestines . Regulation EPHB2 PRKAR2B 9892211 586637 We have studied the *effects* of EGF , IGF-I , and the activator forskolin on the activation of p42/ extracellular signal regulated kinase ( [ERK] ) 2 , which is a key kinase in mediation of growth factor induced mitogenesis in prostate cancer cells . Regulation EPHB2 PRKCA 11473356 841591 *Involvement* of in mediating [ERK] activation was further confirmed by the inhibition of ERK and the subsequent Egr-1 gene induction with antisense oligonucleotides to PKCalpha . Regulation EPHB2 PRKCA 12048219 968722 Ectopic expression of or -zeta did not *affect* p38 kinase or [ERK] but inhibited the p53 accumulation and caspase-3 activation that are required for NO-induced apoptosis of chondrocytes . Regulation EPHB2 PRKCB 18167130 1869664 The phosphorylation of [ERK] ( 1/2 ) and p38 MAPK was *regulated* by upregulated in HCC cells through the integrated use of PKC beta RNA interference , the PKC beta specific inhibitor enzastaurin and a PKC activator phorbol-12-myristate-13-acetate . Regulation EPHB2 PRL 16840547 1613064 Because S179D PRL and basic fibroblast growth factor (bFGF) have both been shown to activate ERK , the *effect* of S179D on bFGF induced [ERK] signaling was examined . Regulation EPHB2 PRSS21 20947496 2353714 Compared with wild-type controls , GPRC6A ( -/- ) null mice exhibit significantly less [ERK] activation and Egr-1 expression in both bone marrow and *response* to pharmacological doses of testosterone in vivo . Regulation EPHB2 PRTN3 12444202 1017413 Novel *effects* of neutrophil derived and elastase on the vascular endothelium involve in vivo cleavage of NF-kappaB and proapoptotic changes in JNK , [ERK] , and p38 MAPK signaling pathways . Regulation EPHB2 PSEN1 18367332 1892592 *regulates* [extracellular regulated kinase (Erk)] activity by a protein kinase C alpha dependent mechanism . Regulation EPHB2 PSEN2 18367332 1892593 *regulates* [extracellular regulated kinase (Erk)] activity by a protein kinase C alpha dependent mechanism . Regulation EPHB2 PSTPIP2 24407241 2900622 Supporting this idea , PSTPIP2 interacted with LYN and the expression of a dominant negative LYN ( LYN DN ) overwhelmed the inhibitory *effect* of on differentiation and [ERK] signaling . Regulation EPHB2 PTEN 12479095 1023944 The objective of this paper was to study extracellular signal regulated kinase ( ERK ) activation in endometrial carcinoma cell line Ishikawa under the stimulation of IGF-1 , and to elucidate the *role* of suppressor encoprotein in activation of [ERK] . Regulation EPHB2 PTGS2 12934647 1132841 Salicylate inhibited the IL-1beta and TNF-alpha induced expressions , *regulated* the activation of [ERK] , IKK and IkappaB degradation , and the subsequent activation of NF-kappaB , in neonatal rat ventricular cardiomyocytes . Regulation EPHB2 PTHLH 19633068 2137928 In MV522 cells , had similar *effects* on DNA synthesis , cyclin A2 expression , pRb levels , CDK2-cyclin A2 association , and [ERK] activation . Regulation EPHB2 PTK2 11425486 831338 These results demonstrated that GO and MGO triggered two distinct signal cascades , one for *dependent* control of [ERK] and another for PTK independent redox linked activation of JNK/p38 MAPK and caspases in HUVECs , depending on the structure of the carbon skeleton of the chemicals . Regulation EPHB2 PTK6 11425486 831339 These results demonstrated that GO and MGO triggered two distinct signal cascades , one for *dependent* control of [ERK] and another for PTK independent redox linked activation of JNK/p38 MAPK and caspases in HUVECs , depending on the structure of the carbon skeleton of the chemicals . Regulation EPHB2 PTK7 11425486 831340 These results demonstrated that GO and MGO triggered two distinct signal cascades , one for dependent *control* of [ERK] and another for PTK independent redox linked activation of JNK/p38 MAPK and caspases in HUVECs , depending on the structure of the carbon skeleton of the chemicals . Regulation EPHB2 PTPN11 10669730 665970 To address the molecular mechanism for the positive *role* of in mediating [Erk] induction , we evaluated the activation of signaling components upstream of Erk in Shp-2 mutant cells . Regulation EPHB2 PTPN11 11085989 810053 Divergent *roles* of in [ERK] activation by leptin receptors . Regulation EPHB2 PTPN11 12721296 1106501 The protein tyrosine phosphatase *regulates* interleukin-1 induced [ERK] activation in fibroblasts . Regulation EPHB2 PTPN11 14963045 1235699 These results indicate that is *involved* in the Ras independent modification of [Erk] signals that is necessary for the morphogenetic activity of CagA . Regulation EPHB2 PTPN11 14967142 1209099 *regulates* SRC family kinase activity and [Ras/Erk] activation by controlling Csk recruitment . Regulation EPHB2 PTPN11 16181551 1461991 Both and MKP5 *play* some roles in P2Y receptor mediated activation of [MEK/ERK] , p38 signaling pathways and prostate cancer invasion . Regulation EPHB2 PTPN11 16181551 1462007 positively *regulates* [ERK] activation and prostate cancer invasion , whereas MKP5 inhibits the invasion by suppressing p38 activation . Regulation EPHB2 PTPN11 19509291 2108655 Because the amino acid sequence surrounding tyrosine 453 is similar to the immunoreceptor tyrosine based inhibitory motif , , a positive *regulator* of [Erk] , binds to GAREM in this phosphorylation dependent manner . Regulation EPHB2 PTPN11 22362894 2606215 also *plays* a central role in mediating [FGF/GAB/ERK] activity , required for epithelial repair program . Regulation EPHB2 PTPN11 24003223 2851345 Furthermore , GAREM2 and *regulate* [Erk] activity in EGF stimulated cells . Regulation EPHB2 PTPN11 24628801 2925544 The ubiquitous non-receptor protein tyrosine phosphatase ( encoded by PTPN11 ) *plays* a key role in [RAS/ERK] signaling downstream of most , if not all growth factors , cytokines and integrins , although its major substrates remain controversial . Regulation EPHB2 PTPN11 9632795 513088 These observations suggest that Gab1 acts as an adapter molecule in transmitting signals to ERK MAP kinase for the cytokine receptor gp130 and that , PI-3 kinase , and Ras are *involved* in Gab1 mediated [ERK] activation . Regulation EPHB2 PTPN5 12483215 1032909 We have investigated the *role* of , a striatal enriched tyrosine phosphatase , in the regulation of [ERK] activity in rat neurons . Regulation EPHB2 PTPN5 18708052 2008846 Here , we investigate the *role* of in D2R mediated [ERK] signaling , especially in dopaminergic neuronal development . Regulation EPHB2 PTPN5 24117863 2896453 *Regulation* of [phospho-ERK] by underlies important neuronal activities . Regulation EPHB2 PTX3 11287337 800051 Both the purified beta-oligomer binding subunit of the PTX holotoxin and a PTX holotoxin mutant genetically engineered to eliminate intrinsic ADP ribosyltransferase activity completely reproduced *effects* on [ERK] activation , suggesting that PTX induced ERK activation involves a novel PKC dependent signaling mechanism that is independent of either Ras or Raf-1 activities and does not require G protein ADP ribosylation . Regulation EPHB2 PTX3 15194005 1259724 did not *affect* on the LPA induced early gene induction and [ERK] activation , ruling out the role of Gi/o protein ( s ) in the process . Regulation EPHB2 PTX4 11287337 800050 Both the purified beta-oligomer binding subunit of the PTX holotoxin and a PTX holotoxin mutant genetically engineered to eliminate intrinsic ADP ribosyltransferase activity completely reproduced *effects* on [ERK] activation , suggesting that PTX induced ERK activation involves a novel PKC dependent signaling mechanism that is independent of either Ras or Raf-1 activities and does not require G protein ADP ribosylation . Regulation EPHB2 PTX4 15194005 1259723 did not *affect* on the LPA induced early gene induction and [ERK] activation , ruling out the role of Gi/o protein ( s ) in the process . Regulation EPHB2 PXN 15138291 1246203 Vinculin modulation of interactions *regulates* [ERK] to control survival and motility . Regulation EPHB2 PXN 19494198 2167975 [ERK] *regulates* cell migration during wound healing in vitro by modulating the phosphorylation of FAK and and the consequent formation of focal adhesions . Regulation EPHB2 RAB11A 23535298 2772541 Src family kinases (SFKs) regulate the completion of cytokinesis through signal transduction pathways that lead to the *dependent* phosphorylation of [ERK] and its localization to the midbody of cytokinetic cells . Regulation EPHB2 RAB5A 24466349 2907871 Vinculin and were *involved* in the S. aureus induced phosphorylation of MAP kinases ( p38 , [Erk] , and JNK ) and IL-6 expression . Regulation EPHB2 RAC1 11453646 837055 is activated by tumor necrosis factor alpha and is *involved* in activation of [Erk] . Regulation EPHB2 RAC1 12132588 966902 Our results showed that LPS induced the activation of [ERK] and p38 MAP kinase in a *dependent* manner , suggesting a mediatory role of Rac1 in LPS signaling to MAPKs stimulation . Regulation EPHB2 RAC1 12511425 1070850 We conclude from these data that *dependent* activation of [MAPK/ERK] is a critical event in the immediate phagocytic response of PMNs to microbial challenge . Regulation EPHB2 RAC1 15743761 1396874 Dominant negative inhibited angiotensin II-stimulated ROS production , JNK activation , and p38 MAPK activation but did not *affect* [ERK] activation . Regulation EPHB2 RAC1 17255340 1691108 Inhibition with toxin B showed that *plays* no role in [ERK] activation in HCs . Regulation EPHB2 RAC1 17438281 1729247 Chimaerin and *regulate* cell number , adherens junctions , and [ERK] MAP kinase signaling in the Drosophila eye . Regulation EPHB2 RAC1 22061968 2547678 *regulates* NT3 stimulated [Mek-Erk] signaling , directing marrow isolated adult multilineage inducible ( MIAMI ) cells toward an early neuronal phenotype . Regulation EPHB2 RAC2 11453646 837056 is activated by tumor necrosis factor alpha and is *involved* in activation of [Erk] . Regulation EPHB2 RAC2 12132588 966903 Our results showed that LPS induced the activation of [ERK] and p38 MAP kinase in a *dependent* manner , suggesting a mediatory role of Rac1 in LPS signaling to MAPKs stimulation . Regulation EPHB2 RAC2 12511425 1070851 We conclude from these data that *dependent* activation of [MAPK/ERK] is a critical event in the immediate phagocytic response of PMNs to microbial challenge . Regulation EPHB2 RAC2 15743761 1396875 Dominant negative inhibited angiotensin II-stimulated ROS production , JNK activation , and p38 MAPK activation but did not *affect* [ERK] activation . Regulation EPHB2 RAC2 17438281 1729248 Chimaerin and *regulate* cell number , adherens junctions , and [ERK] MAP kinase signaling in the Drosophila eye . Regulation EPHB2 RAC3 11453646 837057 is activated by tumor necrosis factor alpha and is *involved* in activation of [Erk] . Regulation EPHB2 RAC3 12132588 966904 Our results showed that LPS induced the activation of [ERK] and p38 MAP kinase in a *dependent* manner , suggesting a mediatory role of Rac1 in LPS signaling to MAPKs stimulation . Regulation EPHB2 RAC3 12511425 1070852 We conclude from these data that *dependent* activation of [MAPK/ERK] is a critical event in the immediate phagocytic response of PMNs to microbial challenge . Regulation EPHB2 RAC3 15743761 1396876 Dominant negative inhibited angiotensin II-stimulated ROS production , JNK activation , and p38 MAPK activation but did not *affect* [ERK] activation . Regulation EPHB2 RAC3 17438281 1729249 Chimaerin and *regulate* cell number , adherens junctions , and [ERK] MAP kinase signaling in the Drosophila eye . Regulation EPHB2 RAD50 11228165 788451 is *involved* in cell stretching modulation of p38 but not [ERK] or JNK MAP kinase . Regulation EPHB2 RAD50 11479306 860728 The *role* of in [ERK] and Akt activity was further demonstrated by our observation that an active form of Epac , which activated Rap1 in the absence of cAMP , increased ERK and Akt phosphorylation . Regulation EPHB2 RAD50 14551200 1175560 Experiments involving the expression of the dominant negative mutants of Ras and Rap1 signaling ( RasN17 or Rap1N17 ) indicate that both GTPases Ras and Rap1 are recruited for the ERK activation by VIP and PACAP38 , whereas is poorly *involved* in TRH or EGF induced [ERK] activation . Regulation EPHB2 RAD50 15278365 1277266 In confluent NHK , cyclic AMP decreased [extracellular regulated kinase (ERK)] phosphorylation and cell proliferation in a Ras independent and *dependent* manner . Regulation EPHB2 RAD50 20877310 2381766 Moreover , we found that negatively *regulated* GNDF induced [ERK] activation and neurite outgrowth . Regulation EPHB2 RAD50 24523415 2924205 Moreover , our results showed that NMDA mediated activation of the small G-protein Ras is necessary for PI3K/Akt pathway activation , whereas was *involved* in NMDA phosphorylation of [ERK] . Regulation EPHB2 RAF1 11604401 888251 [ERK] activation in *response* to constitutively active or growth factor stimulus was attenuated in cells expressing MKK1 C-terminal deletion mutants . Regulation EPHB2 RAF1 12821130 1104135 These results demonstrate that *dependent* [ERK] activation mediated by PTX-sensitive G protein coupled receptors may be a potent signal in S1P induced HCEC tube formation . Regulation EPHB2 RAF1 15919658 1433651 Studies with PP1/2 showed that phosphorylation of c-Src was required for tyrosine phosphorylation of , an upstream *regulator* of [Erk] . Regulation EPHB2 RAF1 19026988 2017158 Subsequently , the oridonin induced autophagy was also suppressed by or JNK inhibition accompanied by the increase of apoptosis , but it was not *affected* by [ERK] or p38 inhibition . Regulation EPHB2 RAF1 21831839 2473005 MAPK kinase ( MEK ) [/ERK] activation is *regulated* by interactions of with phosphatidylethanolamine binding protein 1 ( PEBP1 ) . Regulation EPHB2 RAPGEF1 17825818 1810336 ( iv ) phosphorylated-inactive PP2A level decreases in C3G expressing clones and , most importantly , ( v ) okadaic acid reverts the inhibitory *effect* of on [ERK] phosphorylation . Regulation EPHB2 RASA1 12675684 1076711 Both tyrosine phosphatase activity and activity were *responsible* for SptP inhibition of Raf ( Y340D ) -induced [ERK] activation , but only GAP activity was responsible for inhibition of the membrane localized forms of Raf-1 . Regulation EPHB2 RASA1 20877310 2381767 Moreover , we found that negatively *regulated* GNDF induced [ERK] activation and neurite outgrowth . Regulation EPHB2 RASGRF1 23145787 2722856 In the present study we characterized the *role* of in Ca2+ and [Ras?ERK] signalling after IL-1 stimulation . Regulation EPHB2 RASGRF2 23145787 2722857 In the present study we characterized the *role* of in Ca2+ and [Ras?ERK] signalling after IL-1 stimulation . Regulation EPHB2 RASGRP1 22719950 2616511 The Ras-guanyl nucleotide exchange factor *plays* a critical role in T cell receptor mediated [Erk] activation . Regulation EPHB2 REG1A 18388567 1907172 This study examined the *role* of in suppressed T-cell p-38 , [ERK] , and cytokine production after EtOH intoxication and burn injury . Regulation EPHB2 RELA 15100369 1239795 mRNA expression of MCP-1 was abolished by inhibition , but were not *affected* by the inhibition of [ERK] , JNK , or p38 . Regulation EPHB2 RELA 16283237 1484084 ERK activity is required for NFkappaB mediated transcription of Nos2 in insulin producing INS-1E cells , indicating that [ERK] *regulates* Nos2 expression by increasing the transactivating capacity of . Regulation EPHB2 RELA 20558745 2302502 rHSP90alpha induced the activities of [ERK] , PI3K/Akt , and NF-kappaB p65 , but only activation was *involved* in HSP90alpha induced integrin alpha(V) expression . Regulation EPHB2 RHO 10066681 593657 Overexpression of or DNRhoA did not *affect* angiotensin II-induced activation of [ERK] . Regulation EPHB2 RHOA 12874183 1120959 The purpose of this investigation was to examine whether *regulates* [ERK] downstream signaling and cellular proliferation through its effects on the cytoskeleton and the nuclear localization of ERK . Regulation EPHB2 RHOA 15225621 1268297 Here , we show that inhibition of prevents the phosphorylation of Akt , but does not *affect* the phosphorylation of [ERK] . Regulation EPHB2 RHOA 15494214 1354860 The data indicate that [ERK] activation is essential for phenylephrine stimulation of NHE1 , and that ERK and are *involved* in LPA stimulation of NHE1 by more than one mechanism . Regulation EPHB2 RHOA 19074159 2030552 We examined whether can substantially *affect* [ERK] activity via this MEKK1 mediated crosstalk between RhoA and EGFR-ERK pathway . Regulation EPHB2 RHOA 19074159 2030554 Our results indicated possible *roles* of in affecting [ERK] activities via MEKK1 mediated crosstalk , which seems to be supported by indications from several experimental studies that may also implicate the collective regulation of cell fate and progression of cancer and other diseases . Regulation EPHB2 RICTOR 20512842 2270586 In this report , we focused on studying the *role* of mTORC1 and in rapamycin mediated Akt and [ERK] phosphorylation , and the antitumor effect of rapamycin in cancer cells in combination with Akt and ERK inhibitors . Regulation EPHB2 RICTOR 20512842 2270620 Collectively , we conclude that *plays* a much more important role than mTORC1 in rapamycin mediated phosphorylation of Akt and [ERK] , and cotargeting AKT and ERK signaling may be a new strategy for enhancing the efficacy of rapamycin based therapeutic approaches in cancer cells . Regulation EPHB2 RMDN3 18771726 1980338 We demonstrated here , that could *regulate* [ERK] activity on Raf level , since MEK inhibitor and dominant negative Raf-1 but not Ras could inhibit the ERK activation induced by PTPIP51 . Regulation EPHB2 RPGR 18649147 2020023 Furthermore , a significant interactive *effect* of NMS and on [p-ERK] expression was observed in laminae III-IV of the lumbosacral dorsal horn . Regulation EPHB2 RPSA 19998339 2272071 [ERK/MAPK] activation *involves* hypoxia induced expression and contributes to apoptosis resistance in gastric cancer . Regulation EPHB2 RPTOR 20512842 2270587 In this report , we focused on studying the *role* of and mTORC2 in rapamycin mediated Akt and [ERK] phosphorylation , and the antitumor effect of rapamycin in cancer cells in combination with Akt and ERK inhibitors . Regulation EPHB2 RRAS 24439224 2901523 In addition , we investigated the intracellular signaling pathways in cervical cancer and found that expression correlated positively with EphB2 in clinical samples , and its activity was *regulated* by [EphB2] in cervical cancer . Regulation EPHB2 S1PR3 21749389 2452458 The use of specific receptor antagonists indicated that the receptor was dominantly *involved* in S1P induced [ERK] activation and hypopigmentation . Regulation EPHB2 SCRIB 20622900 2321777 The cell polarity regulator *controls* [ERK] activation through a KIM site dependent interaction . Regulation EPHB2 SCRIB 20622900 2321785 These results provide a clear mechanistic explanation of how can *regulate* [ERK] signalling and begin to explain how loss of hScrib during cancer development can contribute to disease progression . Regulation EPHB2 SDC4 22268118 2575499 In conclusion , ASMC produce and shed and although this is increased by the Th1 cytokines , the MAPK [ERK] only *regulates* shedding . Regulation EPHB2 SEPP1 21893096 2496538 In addition , the *effects* of on [Erk] phosphorylation in mouse splenocytes and on the transcriptional activity of NFAT in Jurkat T cells were also investigated . Regulation EPHB2 SET 15703833 1372693 To examine the mode of action by which I-2PP2A/SET suppresses cell proliferation , we determined the *effect* of over expressed on [ERK] activation . Regulation EPHB2 SET 15703833 1372705 By contrast , knocking down I-2PP2A/SET by siRNA resulted in enhancement of ERK and MEK activations , suggesting that negatively *regulates* [MEK/ERK] . Regulation EPHB2 SETD2 22771629 2639544 Notoginsenoside Ft1 promotes angiogenesis via mediated VEGF secretion and the *regulation* of PI3K/AKT and [Raf/MEK/ERK] signaling pathways . Regulation EPHB2 SFTPC 21081108 2376751 The *effects* of on [Raf/MEK/ERK] and PI3K/Akt signaling were dependent on G ( i/o ) , whereas the SPC induced calcium influx was dependent on G ( q ) . Regulation EPHB2 SHC1 10400627 628249 Here we show that the EGF mediated [ERK] activation is abolished by loss of Grb2 , whereas this response is not *affected* by loss of . Regulation EPHB2 SHC1 10400627 628255 These findings strongly support distinct *roles* for Grb2 and in controlling [ERK] and JNK activation after EGF stimulation . Regulation EPHB2 SHC1 10976990 729638 In contrast to their implication in epidermal growth factor (EGF) receptor tyrosine kinase signaling , the adaptor protein , the Grb2/Sos complex , and the small G protein Ras were not *involved* in the activation of [Erk] induced by either LPA or PGF2alpha in MC3T3-E1 cells , suggesting that activation of Erk by Gi and Gq protein coupled receptors is Ras independent in these cells . Regulation EPHB2 SHC1 14576154 1199910 Non-redundant *role* of in [Erk] activation by cytoskeletal reorganization . Regulation EPHB2 SHC1 23584453 2778479 Thus , in addition to its established role in promoting MAP kinase signaling in stimulated cells , negatively *regulates* [Erk] activation in the absence of growth factors and thus could be considered a tumor suppressor in human cells . Regulation EPHB2 SHOC2 20051520 2211696 positively *regulates* [Ras/ERK] MAP kinase signaling by serving as a scaffold for Ras and Raf . Regulation EPHB2 SIAH1 23891150 2830300 X-ray crystallography , mass spectrometry , and functional data demonstrate that these peptide mimetics are efficient covalent inhibitors of Siah and antagonize dependent *regulation* of [Erk] and Hif signaling in the cell . Regulation EPHB2 SIAH2 23891150 2830301 X-ray crystallography , mass spectrometry , and functional data demonstrate that these peptide mimetics are efficient covalent inhibitors of Siah and antagonize *dependent* regulation of [Erk] and Hif signaling in the cell . Regulation EPHB2 SIAH3 23891150 2830302 X-ray crystallography , mass spectrometry , and functional data demonstrate that these peptide mimetics are efficient covalent inhibitors of Siah and antagonize dependent *regulation* of [Erk] and Hif signaling in the cell . Regulation EPHB2 SIRPA 18218778 1864072 Anoikis effector negatively *regulates* [Erk] activity . Regulation EPHB2 SKP1 19956885 2184990 Using c-kit positive SCLC cells ( H209 and H69 cells ) and SCF as a model of the autocrine mechanisms , the *effects* of , LY294002 , PD98059 or STI571 on Akt and [Erk] were assessed by Western blot analysis . Regulation EPHB2 SKP1 21330471 2415116 Half the population phosphorylated [Erk] in *response* to between 0.9 and 1.2 minutes , and S6 phosphorylation followed approximately a minute later ( t & frac12 ; ( pS6 rise ) = 2.2-2.7 minutes ) . Regulation EPHB2 SLC33A1 20492449 2283511 In contrast , the IC2 peptide had no *effect* on AngII/AT1 receptor activation of [ERK] . Regulation EPHB2 SLC33A1 23583236 2783485 *dependent* SS-induced [ERK] activation involves Ca ( 2+ ) inflow and activation of Gaq since Ca ( 2+ ) chelator EGTA or Gaq-specific inhibitor YM-254890 decreased SS-induced ERK activation . Regulation EPHB2 SLC33A1 24095877 2867696 In vitro , Ang II suppressed RECK expression in adult mouse cardiac fibroblasts ( CF ) via *dependent* [ERK/Sp1] activation , but induced MMPs 2 , 14 and 9 via NF-?B , AP-1 and/or Sp1 activation . Regulation EPHB2 SLC39A9 24989471 2948161 Here , we indicate that the induces increase in intracellular zinc level and *plays* an important role in the phosphorylation of Akt and [Erk] in response to BCR activation . Regulation EPHB2 SLC9A3R1 17107942 1700430 We conclude that [ERK] phosphorylation in distal kidney cells by PTH requires PTH1R activation of G ( i ) , which leads to stimulation of metalloprotease mediated cleavage of HB-EGF and transactivation of the EGFR and is *regulated* by . Regulation EPHB2 SLC9A3R2 15115658 1241539 In contrast , the *dependent* increase of [ERK] phosphorylation was not affected by pretreatment with PD98059 in Rat1/NHERF2 cells . Regulation EPHB2 SLC9A3R2 15115658 1241541 Thus , the *dependent* increase of [ERK] phosphorylation occurs in a MEK independent fashion . Regulation EPHB2 SLC9A3R2 15115658 1241546 Pretreatment with PP2 , a specific inhibitor of Src family tyrosine kinase , completely blocked the *dependent* increase of the phosphorylation of [ERK] and Akt , suggesting that NHERF2 up-regulates Erk phosphorylation through a Src family kinase dependent pathway . Regulation EPHB2 SMAD7 17096210 1685771 These data revealed that TbetaRII and *play* the critical roles in TGF-beta1 mediated activation of [ERK] ; Regulation EPHB2 SNAP25 10898734 712118 In contrast , did not *affect* PDGF induced activation of [ERK] at any time point . Regulation EPHB2 SORL1 18362153 1906386 with A-type repeats ( SORLA ) *affects* the amyloid precursor protein dependent stimulation of [ERK] signaling and adult neurogenesis . Regulation EPHB2 SORT1 20813449 2341771 During differentiation , a sustained [Erk] phosphorylation in *response* to was observed , cells began to exit from the cell cycle and exhibit increased neurite-like extensions . Regulation EPHB2 SOS1 10976990 729639 In contrast to their implication in epidermal growth factor (EGF) receptor tyrosine kinase signaling , the adaptor protein Shc , the complex , and the small G protein Ras were not *involved* in the activation of [Erk] induced by either LPA or PGF2alpha in MC3T3-E1 cells , suggesting that activation of Erk by Gi and Gq protein coupled receptors is Ras independent in these cells . Regulation EPHB2 SOS1 11791173 901785 Here we determined the efficacy of Shc and N-Shc toward Erk activation in NGF treated PC12 cells , and found that N-Shc transduced *dependent* [Erk] activation less efficiently than Shc . Regulation EPHB2 SOS1 24497027 2933190 *regulates* sustained TCR mediated [Erk] activation . Regulation EPHB2 SOS2 10976990 729640 In contrast to their implication in epidermal growth factor (EGF) receptor tyrosine kinase signaling , the adaptor protein Shc , the complex , and the small G protein Ras were not *involved* in the activation of [Erk] induced by either LPA or PGF2alpha in MC3T3-E1 cells , suggesting that activation of Erk by Gi and Gq protein coupled receptors is Ras independent in these cells . Regulation EPHB2 SOS2 11791173 901786 Here we determined the efficacy of Shc and N-Shc toward Erk activation in NGF treated PC12 cells , and found that N-Shc transduced *dependent* [Erk] activation less efficiently than Shc . Regulation EPHB2 SPRED1 15465815 1342206 negatively *regulates* interleukin-3 mediated [ERK/mitogen] activated protein (MAP) kinase activation in hematopoietic cells . Regulation EPHB2 SPRED1 20047999 2192978 , a negative *regulator* of [Ras-MAPK-ERK] , is enriched in CNS germinal zones , dampens NSC proliferation , and maintains ventricular zone structure . Regulation EPHB2 SPRY1 20105280 2213058 Phospho-Erk1 and Erk2 levels were elevated in the lens but not in the cornea and and Spry 2 , negative *regulators* of [Ras-Raf-Erk] signaling , were upregulated more in the corneal than in the lens epithelial cells . Regulation EPHB2 SPRY2 20105280 2213059 Phospho-Erk1 and Erk2 levels were elevated in the lens but not in the cornea and Spry 1 and , negative *regulators* of [Ras-Raf-Erk] signaling , were upregulated more in the corneal than in the lens epithelial cells . Regulation EPHB2 SRC 11278310 810922 In contrast , inhibition of Ras or had no *effect* on the sustained [ERK] activity , which was critically dependent on phosphatidylinositol 3-kinase . Regulation EPHB2 SRC 12534349 1079140 Moreover , we showed that both isoforms activate [ERK] phosphorylation in an *dependent* manner , whereas PKC was mainly implicated in ERK activation and EGFR phosphorylation by TP beta . Regulation EPHB2 SRC 12538624 1050198 Surprisingly , although is *involved* in GnRH-A stimulated [ERK] , its involvement is mapped to another region ( -280/-180 ) containing the glycoprotein-specific element . Regulation EPHB2 SRC 12750255 1089219 Interestingly , NT did not stimulate epidermal growth factor receptor transactivation , and epidermal growth factor receptor tyrosine kinase or inhibitors did not *affect* NT-induced [ERK] activation in PANC-1 cells . Regulation EPHB2 SRC 15166244 1273416 The tyrosine kinase inhibitor 4-amino-5- ( 4-chlorophenyl ) -7- ( t-butyl ) pyrazolol [ 3,4-d ] pyrimidine had no *effect* on Tau-Cl induced EGF receptor or [ERK] activation . Regulation EPHB2 SRC 15615697 1380849 Moreover , the *effect* of family kinase inhibitors on EGF stimulated [ERK] phosphorylation was transient , prompting a search for other targets of Src family kinase action . Regulation EPHB2 SRC 15845549 1418605 Down-regulation of endogenously expressed CNK1 by small inhibitory RNA interferes with *dependent* activation of [ERK] . Regulation EPHB2 SRC 16214133 1468866 In addition , transfection of ES cells with DN-Src , or DN-Ras partially inhibited 8-Br-cAMP induced ERK1/2 and consequently PLD activation , whereas cotransfection of DN-Src and DN-Ras completely inhibited ERK1/2 and PLD activation , suggesting that and Ras independently *regulate* [ERK/PLD] activation . Regulation EPHB2 SRC 16809338 1606024 Arrestin is essential to recruit Src to this process , as alpha(2A)AR mediated [ERK] signaling in Arr2 ,3-/- MEFs does not *involve* . Regulation EPHB2 SRC 17562163 1798045 Inhibitors of growth factor receptor ( AG1478 ) and ( PP2 ) and the antioxidant N-acetylcysteine did not *affect* activation of [ERK] and Akt , while the Ras and Raf inhibitors inhibited activation of ERK , but not Akt . Regulation EPHB2 SRC 18080320 1894775 Pretreatment with calcitriol , enhanced TNF induced *dependent* [ERK] activation and tyrosine phosphorylation of the EGFR , but abolished the EGFR-Src independent ERK activation . Regulation EPHB2 SRC 18550646 1940621 PTH mediated regulation of Na+-K+-ATPase requires kinase *dependent* [ERK] phosphorylation . Regulation EPHB2 SRC 20483033 2367790 In the present study , we examined the *role* of in regulating the inhibition of [p-ERK] in the brain following RACK1 over-expression during morphine reward . Regulation EPHB2 SRC 21127402 2372513 Notably , our data also indicated the involvement of *dependent* JNK and [ERK] in zVAD induced ROS production and autophagic death . Regulation EPHB2 SRC 21779479 2457002 In vitro , knockdown of JNK2 or GAB2 inhibits Akt activation by hepatocyte growth factor (HGF) , insulin , and heregulin-1 , while phosphorylation of [ERK] is constitutive and *dependent* . Regulation EPHB2 SST 19910453 2189295 Our results demonstrate that SOM230 and KE108 behave as agonists for inhibition of adenylyl cyclase but antagonize 's *actions* on intracellular calcium and [ERK] phosphorylation . Regulation EPHB2 SST 9142901 428575 Because the extracellular signal regulated protein kinases ( ERKs ) induce the SRE via phosphorylation of transcription factors such as Elk-1 , we examined the *effect* of on [ERK] phosphorylation and activation . Regulation EPHB2 STAB2 24586357 2920171 Hyaluronic acid receptor *regulates* [Erk] phosphorylation and arterial -- venous differentiation in zebrafish . Regulation EPHB2 STAT3 16788692 1599457 Our data suggest a *role* of tyrosine phosphorylated in the suppression of [ERK] activation . Regulation EPHB2 SYK 19342628 2056757 FcgammaRIIIB induced nuclear phosphorylation of [ERK] , and of Elk-1 , was not *affected* by , PI3K , or MEK inhibitors . Regulation EPHB2 SYK 9720763 528567 We report that inhibition of PI3K by wortmannin or an inhibitory p85 construct , p85deltaiSH2 , reduced the TCR induced *dependent* activation of Erk2 , as well as the appearance of [phospho-Erk] and phospho-Mek . Regulation EPHB2 TAB1 17205106 1681312 DETA/NONOate increased also the phosphorylation of JNK and [ERK] in beta-TC6 cells , but these events were not *affected* by . Regulation EPHB2 TAB1 17932218 1844203 The cytokine induced phosphorylation of c-Jun N-terminal kinase and [ERK] was not *affected* by changes in levels . Regulation EPHB2 TERF1 20877310 2381760 Moreover , we found that negatively *regulated* GNDF induced [ERK] activation and neurite outgrowth . Regulation EPHB2 TERF1 24523415 2924199 Moreover , our results showed that NMDA mediated activation of the small G-protein Ras is necessary for PI3K/Akt pathway activation , whereas was *involved* in NMDA phosphorylation of [ERK] . Regulation EPHB2 TERF2 11228165 788445 is *involved* in cell stretching modulation of p38 but not [ERK] or JNK MAP kinase . Regulation EPHB2 TERF2 11479306 860722 The *role* of in [ERK] and Akt activity was further demonstrated by our observation that an active form of Epac , which activated Rap1 in the absence of cAMP , increased ERK and Akt phosphorylation . Regulation EPHB2 TERF2 14551200 1175554 Experiments involving the expression of the dominant negative mutants of Ras and Rap1 signaling ( RasN17 or Rap1N17 ) indicate that both GTPases Ras and Rap1 are recruited for the ERK activation by VIP and PACAP38 , whereas is poorly *involved* in TRH or EGF induced [ERK] activation . Regulation EPHB2 TERF2 15278365 1277260 In confluent NHK , cyclic AMP decreased [extracellular regulated kinase (ERK)] phosphorylation and cell proliferation in a Ras independent and *dependent* manner . Regulation EPHB2 TERF2 20877310 2381761 Moreover , we found that negatively *regulated* GNDF induced [ERK] activation and neurite outgrowth . Regulation EPHB2 TERF2 24523415 2924200 Moreover , our results showed that NMDA mediated activation of the small G-protein Ras is necessary for PI3K/Akt pathway activation , whereas was *involved* in NMDA phosphorylation of [ERK] . Regulation EPHB2 TERF2IP 11228165 788447 is *involved* in cell stretching modulation of p38 but not [ERK] or JNK MAP kinase . Regulation EPHB2 TERF2IP 11479306 860724 The *role* of in [ERK] and Akt activity was further demonstrated by our observation that an active form of Epac , which activated Rap1 in the absence of cAMP , increased ERK and Akt phosphorylation . Regulation EPHB2 TERF2IP 14551200 1175556 Experiments involving the expression of the dominant negative mutants of Ras and Rap1 signaling ( RasN17 or Rap1N17 ) indicate that both GTPases Ras and Rap1 are recruited for the ERK activation by VIP and PACAP38 , whereas is poorly *involved* in TRH or EGF induced [ERK] activation . Regulation EPHB2 TERF2IP 15278365 1277262 In confluent NHK , cyclic AMP decreased [extracellular regulated kinase (ERK)] phosphorylation and cell proliferation in a Ras independent and *dependent* manner . Regulation EPHB2 TERF2IP 20877310 2381764 Moreover , we found that negatively *regulated* GNDF induced [ERK] activation and neurite outgrowth . Regulation EPHB2 TERF2IP 24523415 2924203 Moreover , our results showed that NMDA mediated activation of the small G-protein Ras is necessary for PI3K/Akt pathway activation , whereas was *involved* in NMDA phosphorylation of [ERK] . Regulation EPHB2 TGFB1 10455028 638399 had no inhibitory *effect* on [ERK] activation induced by PDGF-BB or bFGF . Regulation EPHB2 TGFB1 10880840 709211 In the present investigation we have studied the *effect* of on phosphorylation of [ERK] , a MAP-kinase downstream of the Ras pathway . Regulation EPHB2 TGFB1 12163544 972605 Application of the MEK1 inhibitor PD98059 blocked *effects* on [Erk] but had no effect on Akt/PKB phosphorylation . Regulation EPHB2 TGFB1 15069087 1265685 In MLK3 overexpressing cells , [ERK] , JNKs , and p38 MAP kinases were further activated in *response* to compared with the control cells . Regulation EPHB2 TGFB1 19343212 2057367 Specifically , [MEK-ERK] signaling was dose-dependently induced in *response* to in immortalized cells in vitro and in the A. stephensi midgut epithelium in vivo . Regulation EPHB2 TGFBR2 17096210 1685770 These data revealed that and Smad7 *play* the critical roles in TGF-beta1 mediated activation of [ERK] ; Regulation EPHB2 TIE1 12890486 1117333 Localization of and phospholipase D in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Regulation EPHB2 TINF2 20877310 2381762 Moreover , we found that negatively *regulated* GNDF induced [ERK] activation and neurite outgrowth . Regulation EPHB2 TINF2 24523415 2924201 Moreover , our results showed that NMDA mediated activation of the small G-protein Ras is necessary for PI3K/Akt pathway activation , whereas was *involved* in NMDA phosphorylation of [ERK] . Regulation EPHB2 TIRAP 22634720 2675866 Furthermore , we demonstrated that *dependent* [p38/ERK] activation is critical to TLR2 mediated T-cell IFN-? release following EtOH and burn injury . Regulation EPHB2 TJP1 22782886 2645342 *regulates* [Erk] , Smad1/5/8 , Smad2 , and RhoA activities to modulate self-renewal and differentiation of mouse embryonic stem cells . Regulation EPHB2 TLR2 16951362 1610467 Our investigations revealed that immunocompetent , TLR4 , and MyD88 knockout mice were not more susceptible to invasive aspergillosis as compared with wild-type mice and that the in vitro phosphorylation of the MAPKs [ERK] and p38 was not *affected* in TLR2 , TLR4 , or MyD88 knockout mice following stimulation with conidia . Regulation EPHB2 TLR4 16879219 1593874 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by [MEK/ERK] signaling and NFkappaB activation and that membrane bound CD14 and are *involved* in this mechanism . Regulation EPHB2 TLR4 16951362 1610468 Our investigations revealed that immunocompetent TLR2 , , and MyD88 knockout mice were not more susceptible to invasive aspergillosis as compared with wild-type mice and that the in vitro phosphorylation of the MAPKs [ERK] and p38 was not *affected* in TLR2 , TLR4 , or MyD88 knockout mice following stimulation with conidia . Regulation EPHB2 TLR4 17237423 1690061 In this study , we show that pneumolysin is required for up-regulation of MUC5AC mucin via *dependent* activation of [ERK] in human epithelial cells in vitro and in mice in vivo . Regulation EPHB2 TLR4 20636402 2334928 A history of atopy in children was associated with impaired LPS induced *dependent* phosphorylation of ( p42/44 ) [ERK] and p38 MAPK by CD4 ( + ) monocytes . Regulation EPHB2 TLR4 21881005 2510432 Basolateral LPS inhibits NHE3 and HCOFormula absorption through *dependent* [ERK] activation in medullary thick ascending limb . Regulation EPHB2 TLR4 22703984 2659341 did not *affect* phosphorylated [ERK] levels . Regulation EPHB2 TLR4 22940633 2672612 Here , we demonstrate that attenuated extracellular-signal regulated kinase ( [ERK] ) 1 and 2 signaling in *response* to activation results in failure to induce IL-10 expression in monocytes from CRMO patients . Regulation EPHB2 TMED7 24021283 2846094 In contrast , activation of the MAP kinases p38 , [ERK] and JNK was not *affected* by ( Kip1 ) overexpression . Regulation EPHB2 TMEFF2 23936739 2826999 Using prostate cell lines , here we examine the *role* of in [ERK] and Akt activation , two pathways implicated in prostate cancer progression and that have been shown to cross talk in several cancers . Regulation EPHB2 TMEFF2 23936739 2827003 Our results show that different forms of distinctly *affect* Akt and [ERK] activation and this may contribute to a different cellular response of either proliferation or tumor suppression . Regulation EPHB2 TNF 10913368 716292 Furthermore , we provide evidence that the *dependent* activation of [ERK] and cPLA(2) requires the intact death domain of TNF-R55 . Regulation EPHB2 TNF 12543078 1028754 Together , the p43 induced production was *controlled* by NFkB , p38 MAPK , and [ERK] that is dependent on the activities of PLC and PKC . Regulation EPHB2 TNF 12887130 1116902 had no *effect* on either IRS-1 phosphorylation or [ERK] in VSMC . Regulation EPHB2 TNF 14597634 1187476 In vitro kinase assays as well as immunoblot analysis with antibodies specific for activated MAPKs indicated that H ( 2 ) O ( 2 ) produced in *response* to potentiates the activation of JNK and p38 induced by this cytokine but inhibits that of [ERK] . Regulation EPHB2 TNF 15454113 1301146 These results suggest that PA and induce the up-regulation of CD83 and that their action is *regulated* by [ERK] and JNK . Regulation EPHB2 TNF 16129431 1461137 In addition , we provide evidence for the involvement of the signaling components Fas associated death domain protein ( FADD ) , caspase-8 , and c-FLIP in the pathway activating [ERK] in *response* to . Regulation EPHB2 TNF 16934445 1633034 and [ERK] regulates the up-regulation of MT1-MMP mRNA in *response* to . Regulation EPHB2 TNF 17114809 1677192 Additional studies demonstrated that *effects* on DNA synthesis , [ERK] , and Akt phosphorylation are not mediated through cell surface Gi -coupled S1P receptors , because none of these responses were inhibited by pertussis toxin . Regulation EPHB2 TNF 18080320 1894776 Pretreatment with calcitriol , enhanced induced EGFR-Src *dependent* [ERK] activation and tyrosine phosphorylation of the EGFR , but abolished the EGFR-Src independent ERK activation . Regulation EPHB2 TNF 20691248 2311985 This study aims to elucidate the beneficial *role* of and HSP-70 in the regulation of apoptotic proteins and [ERK] signaling in hypoxic injury . Regulation EPHB2 TNF 23835476 2820892 Mlkl-deficient MEFs and macrophages were indistinguishable from wild-type cells in their ability to activate NF-?B , [ERK] , JNK , and p38 in *response* to and lipopolysaccharides (LPS) , respectively . Regulation EPHB2 TNFSF11 11719504 904133 We find that although pretreatment of BMMs with IL-4 does not alter M-CSF signaling , it reversibly blocks *dependent* activation of the NF-kappa B , JNK , p38 , and [ERK] signals . Regulation EPHB2 TNFSF11 19756392 2183395 However , we demonstrate that silibinin can block the activation of NF-?B , c-Jun N-terminal kinase (JNK) , p38 mitogen activated protein (MAP) kinase , and extracellular signal regulated kinase ( [ERK] ) in osteoclast precursors in *response* to . Regulation EPHB2 TNFSF11 20135643 2235898 Furthermore , RANKL significantly reduces extracellular signal regulated protein kinase ( ERK ) activity , a putative suppressor of osteoclastogenesis , but osteoblast derived GAGs eliminate the inhibitory *effects* of on [ERK] activity . Regulation EPHB2 TNFSF11 22484180 2595323 In defining the signaling pathways , ginsenoside Rh2 was shown to moderately inhibit NF-?B activation and [ERK] phosphorylation in *response* to stimulation in BMM cells without any effect on p38 and c-Jun N-terminal kinase (JNK) . Regulation EPHB2 TNFSF11 23000100 2689143 NecroX-7 significantly inhibited the NF-?B signaling pathway without affecting the activation of the mitogen activated protein kinases ( MAPKs ) JNK , p38 , and [ERK] in *response* to . Regulation EPHB2 TP53 15078887 1257709 Repressing p53 with pifithrin-alpha or small interfering RNA increased ERK phosphorylation by H ( 2 ) O ( 2 ) , indicating that *dependent* suppression of [ERK] activity may contribute to the bi-stable single cell responses observed . Regulation EPHB2 TP53 16829532 1606412 Introduction of intracellular- or extracellular generated O2- during NO generation resulted in a concomitant increase in oxidative intermediates with a decrease in steady-state NO concentrations and a proportional reduction in the levels of sGC , [ERK] , HIF-1alpha , and *regulation* . Regulation EPHB2 TP53 17126425 1771536 [Raf/MEK/ERK] may promote cell cycle arrest in prostate cells and this may be *regulated* by as restoration of wild-type p53 in p53 deficient prostate cancer cells results in their enhanced sensitivity to chemotherapeutic drugs and increased expression of Raf/MEK/ERK pathway . Regulation EPHB2 TP53 17208232 1688970 *regulates* [ERK] activation in carboplatin induced apoptosis in cervical carcinoma : a novel target of p53 in apoptosis . Regulation EPHB2 TRAPPC4 24104608 2867778 Expression of synbindin was examined in normal gastric mucosa ( n = 44 ) , intestinal metaplastic gastric mucosa ( n = 66 ) , and GC tissues ( n=52 ) , and the biological *effects* of on tumor growth and [ERK] signaling were detected in cultured cells , nude mice , and human tissue samples . Regulation EPHB2 TRIB3 23319603 2738260 In accordance with the chemical screen , kinome small interfering RNA high throughput screens identified , a known *regulator* of [MAPK-ERK] , among the most significant hits . Regulation EPHB2 TSC1 15757502 1409724 Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of [ERK] and *involves* phosphorylation of . Regulation EPHB2 TXNIP 21771725 2484480 We then evaluated 's *effects* on [ERK] activation through various growth stimulators and their receptors . Regulation EPHB2 UCN2 17218420 1709710 In addition , cAMP and [ERK] *responses* were blocked by the CRF2 antagonist , astressin2-B . Regulation EPHB2 UCN2 19255503 2045211 In porcine aortic endothelial cells ( PAE ) the *effects* of on NO production and [ERK] , Akt , p38 and eNOS phosphorylation were examined in absence or presence of the adenylyl cyclase agonist forskolin and antagonist 2'5 ' dideoxyadenosine , the Ca2+ ionophore A23187 , the Ca2+-calmodulin-kinase inhibitor KN93 , the CRFR2 blocker astressin 2B and of the protein kinases specific inhibitors UO126 , wortmannin and SB203580 . Regulation EPHB2 UMOD 24269936 2898329 Therefore , the current study aims to examine the *roles* of in the development and expression of METH induced locomotor sensitization as well as the accompanying [extracellular regulated kinase (ERK)] activation in the nucleus accumbens (NAc) , caudate putamen (CPu) and prefrontal cortex (PFc) in mice . Regulation EPHB2 UTP15 10585878 571585 However , PP2 inhibited [ERK] activation in *response* to NE and , but not in response to EGF or NGF . Regulation EPHB2 UTP18 10585878 571583 However , PP2 inhibited [ERK] activation in *response* to NE and , but not in response to EGF or NGF . Regulation EPHB2 UTP20 10585878 571581 However , PP2 inhibited [ERK] activation in *response* to NE and , but not in response to EGF or NGF . Regulation EPHB2 UTP23 10585878 571586 However , PP2 inhibited [ERK] activation in *response* to NE and , but not in response to EGF or NGF . Regulation EPHB2 UTP3 10585878 571584 However , PP2 inhibited [ERK] activation in *response* to NE and , but not in response to EGF or NGF . Regulation EPHB2 UTP6 10585878 571582 However , PP2 inhibited [ERK] activation in *response* to NE and , but not in response to EGF or NGF . Regulation EPHB2 UTS2 12495783 1033479 To investigate the intracellular signaling pathways involved in this process , we examined the *effects* of on activation of extracellular signal regulated kinase ( [ERK] ) and focal adhesion kinase ( FAK ) in VSMCs . Regulation EPHB2 UTS2 12697688 1081359 To investigate whether UII acts as an autocrine/paracrine growth factor for renal epithelial cells , we have studied the *effects* of human ( hUII ) on DNA synthesis , cytosolic free Ca ( 2+ ) concentration ( [ Ca ( 2+ ) ] ( i ) ) , [ERK] activation , and protooncogene (c-myc) expression in a porcine renal epithelial cell line ( LLCPK1 ) . Regulation EPHB2 VAV1 10898494 712069 Here , we analyzed the *effects* of on three known downstream targets of Ras , i. e. activation of [ERK] and NFAT , and up-regulation of the activation antigen CD69 . Regulation EPHB2 VAX1 22183394 2531281 Examples of this are the repression of EphB1 by Isl2 , and *regulation* of [EphB2/EphB3] expression . Regulation EPHB2 VAX2 22183394 2531282 Examples of this are the repression of EphB1 by Isl2 , and *regulation* of [EphB2/EphB3] expression . Regulation EPHB2 VCL 24466349 2907870 and Rab5 were *involved* in the S. aureus induced phosphorylation of MAP kinases ( p38 , [Erk] , and JNK ) and IL-6 expression . Regulation EPHB2 VDR 22878203 2671752 Thus might not be *involved* in [ERK] phosphorylation by vitamin D ( 3 ) . Regulation EPHB2 VEGFA 11719508 904170 Moreover , catalase , the lipoxygenase inhibitor nordihydroguaiaretic acid , the synthetic ROS scavenger EUK-134 , and phosphatidylinositol 3-kinase inhibitor wortmannin all reduce [ERK] phosphorylation in *response* to , and antioxidants prevent VEGF dependent mitogenesis . Regulation EPHB2 VEGFA 22406998 2624335 Importantly , Ginsenoside Rg3 attenuated the phosphorylation cascade of the *dependent* [p38/ERK] signaling in vitro . Regulation EPHB2 VEGFA 22771629 2639543 Notoginsenoside Ft1 promotes angiogenesis via HIF-1a mediated secretion and the *regulation* of PI3K/AKT and [Raf/MEK/ERK] signaling pathways . Regulation EPHB2 VRK3 16845380 1592251 Negative *regulation* of [ERK] activity by mediated activation of VHR phosphatase . Regulation EPHB2 VRK3 18035061 1852159 Our results suggest that in addition to neuronal cells , various other rodent adult tissues and embryos possess a common signaling mechanism which is involved in an indirect *regulation* of [ERK] activity by mediated VHR activity . Regulation EPHB2 WNK2 18593598 1953644 Here we provide mechanistic insight into how *affects* [ERK] activation . Regulation EPHB2 XIAP 20655298 2305077 Taken together , our results demonstrate that *plays* a key role in shear stress stimulated [ERK] activation by maintaining the Src-accessible location of FAK . Regulation EPHB2 XRCC5 11228165 788446 is *involved* in cell stretching modulation of p38 but not [ERK] or JNK MAP kinase . Regulation EPHB2 XRCC5 11479306 860723 The *role* of in [ERK] and Akt activity was further demonstrated by our observation that an active form of Epac , which activated Rap1 in the absence of cAMP , increased ERK and Akt phosphorylation . Regulation EPHB2 XRCC5 14551200 1175555 Experiments involving the expression of the dominant negative mutants of Ras and Rap1 signaling ( RasN17 or Rap1N17 ) indicate that both GTPases Ras and Rap1 are recruited for the ERK activation by VIP and PACAP38 , whereas is poorly *involved* in TRH or EGF induced [ERK] activation . Regulation EPHB2 XRCC5 15278365 1277261 In confluent NHK , cyclic AMP decreased [extracellular regulated kinase (ERK)] phosphorylation and cell proliferation in a Ras independent and *dependent* manner . Regulation EPHB2 XRCC6 11228165 788449 is *involved* in cell stretching modulation of p38 but not [ERK] or JNK MAP kinase . Regulation EPHB2 XRCC6 11479306 860726 The *role* of in [ERK] and Akt activity was further demonstrated by our observation that an active form of Epac , which activated Rap1 in the absence of cAMP , increased ERK and Akt phosphorylation . Regulation EPHB2 XRCC6 14551200 1175558 Experiments involving the expression of the dominant negative mutants of Ras and Rap1 signaling ( RasN17 or Rap1N17 ) indicate that both GTPases Ras and Rap1 are recruited for the ERK activation by VIP and PACAP38 , whereas is poorly *involved* in TRH or EGF induced [ERK] activation . Regulation EPHB2 XRCC6 15278365 1277264 In confluent NHK , cyclic AMP decreased [extracellular regulated kinase (ERK)] phosphorylation and cell proliferation in a Ras independent and *dependent* manner . Regulation EPHB2 ZGLP1 22412973 2567175 In this report , we characterise the relationship between L-type VGCC mediated changes in intracellular Ca ( 2+ ) concentration ( [ Ca ( 2+ ) ] ( i ) ) and the activation of ERK , and demonstrate that the sustained activation of [ERK] ( up to 30 min ) in *response* to requires the continual activation of the L-type VGCC yet does not require a sustained increase in global [ Ca ( 2+ ) ] ( i ) or Ca ( 2+ ) efflux from the endoplasmic reticulum . Regulation EPHB3 EFNB1 20633976 2316730 Identification of expression in prostatic mesenchyme and a *role* for [EphB-EphrinB] signalling in prostate development . Regulation EPHB4 EFNB1 20633976 2316731 Identification of expression in prostatic mesenchyme and a *role* for [EphB-EphrinB] signalling in prostate development . Regulation EPHB6 EFNB1 20633976 2316732 Identification of expression in prostatic mesenchyme and a *role* for [EphB-EphrinB] signalling in prostate development . Regulation EPO IL1B 9386984 466443 These findings suggest that systemic TNF alpha or are not *involved* in the [erythropoietin] response to ACD . Regulation EPO NT5E 16468051 1561420 The aim of the present study was to evaluate the *role* of in [erythropoietin (EPO)] production and to determine its influence on basal kidney perfusion using a CD73 knockout mutant recently generated by us . Regulation EPO TNF 11225250 763967 The *effects* of and IFN-gamma on cobalt induced [erythropoietin] production in human hepatic cancer cells ( HepG2 ) were examined . Regulation EPO TNF 19468203 2107423 Also , no deficiency of serum [erythropoietin (EPO)] or defective intracellular *response* of erythroid precursors to EPO +/- stimulation was observed . Regulation EPO TNF 9386984 466441 These findings suggest that systemic or IL-1 beta are not *involved* in the [erythropoietin] response to ACD . Regulation EPX ADRB2 8301549 248771 The inhibitory *effect* of stimulation on leukotriene C4 ( LTC4 ) secretion and [eosinophil peroxidase (EPO)] release caused by exogenous activation with 10 ( -8 ) to 10 ( -6 ) M formyl-met-leu-phe ( fMLP ) + 5 micrograms/ml of cytochalasin B ( Cyto B ) in purified human peripheral blood eosinophils was studied . Regulation EPX IL1B 9321887 456327 To evaluate the in vivo significance of this observation , we have investigated *effects* of the administration of bacterial lipopolysaccharide (LPS) and on renal [EPO] production in rats . Regulation EPX TNF 14990112 1215353 This study aimed to detect the EPO levels in children 's ACD , to explore the relationship between EPO and tumor necrosis factor alpha (TNF alpha) and interleukin-6 (IL-6) and , to evaluate the *effect* of recombinant human ( rhTNF-alpha ) on [EPO] gene expression . Regulation ERBB2 EPHB2 21403841 2404530 Furthermore , we show that AR-mediated induction of requires ErbB2 , and AR activity , in turn , *regulates* [ErbB2] expression as an AR target gene . Regulation ERBB2 EPHB2 21852536 2468837 Overexpression of [ErbB2] maintains PDH flux by suppressing PDK4 expression in an Erk dependent manner , and signaling also *regulates* PDH flux in ECM attached cells . Regulation ERBB2 FOXA1 22577344 2598137 Moreover , we demonstrate that , in turn , *regulates* the transcription of [ErbB2] signaling genes . Regulation ERBB2 TNF 18701712 1950521 This study was undertaken to determine the *effects* of on EGFR and [ErbB2] activation and intestinal epithelial cell survival . Regulation ERBB2 TNF 8105469 231405 The inverse regulatory *effects* of on [ERBB2] and EGFR mRNA levels were evoked by different signaling pathways of p55 TNF receptors . Regulation ERBB3 TNF 17908459 1803317 Since is *involved* in the activation of both TNF-alpha and [ErbB3] , we established rat models of COPD to investigate the expressions of TACE , TNF-alpha and ErbB3 and to explore the correlations among TACE , TNF-alpha and ErbB3 respectively . Regulation ERBB4 TNF 21617117 2459140 Using neutralizing antibodies , we show that heparin binding EGF-like growth factor ( HB-EGF ) is required for [ErbB4] phosphorylation in *response* to . Regulation ERCC6L STK39 18083840 1837647 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation ERVK-6 CST6 7930530 274702 We postulate that chicken functions to *regulate* [proteinase] activity in the CSF and therefore may function as a protective factor for the cellular elements of the central nervous system . Regulation ERVK-6 CTGF 12753604 1090318 These results indicate that in order to induce changes in porcine fibroblasts a molecule with an intact C-terminal domain is required , and that *regulates* porcine fibroblast extracellular matrix molecule , growth factor , and [proteinase] inhibitor gene expression without apparently affecting matrix metalloproteinase mRNA levels . Regulation ERVK-6 TNF 11773040 899369 The *role* of in stimulating retinal microvascular endothelial cell ( RMVEC ) [proteinase] production was evaluated using isolated murine RMVECs grown in normoxic or hypoxic conditions . Regulation ERVK-6 TNF 20798517 2313709 However , little is known of the *effects* of on cytokine secretion and [protease activated receptor (PAR)] expression in mast cells . Regulation ESAM LIPG 18093422 1838157 To explore the relationship between human umbilical vascular endothelial cells ( HUVECs ) and , and the *effect* of EL on expression of [endothelial cell adhesion molecule] ( ICAM ) . Regulation ESAM TNF 17706953 1816841 Osteoprotegerin upregulates [endothelial cell adhesion molecule] *response* to associated with induction of angiopoietin-2 . Regulation ESAM TNF 22265272 2559734 Osteoprotegerin (OPG) upregulates [endothelial cell adhesion molecule] *response* to by upregulating angiopoietin-2 (Ang-2) . Regulation ESR1 CCND1 23864650 2835146 Although it is known that *regulates* [estrogen receptor] ( ER ) a transactivation using heterologous reporter systems , the in vivo biological significance of cyclin D1 to estrogen dependent signaling , and the molecular mechanisms by which cyclin D1 is involved , are yet to be elucidated . Regulation ESR1 FAS 15094777 1258183 We evaluated the *effects* of inhibition on E2- and TAM induced [estrogen receptor (ER)] transcriptional activity by using transient cotransfection assays with an estrogen-response element reporter construct ( ERE-Luciferase ) . Regulation ESR1 FOXA1 20501593 2263820 Using breast cancer cell lines , we also demonstrate that *regulates* [ERalpha] expression , but not GATA3 . Regulation ESR1 IFI27 22820506 2682253 To investigate the *role* of on [estrogen receptor] ( ER ) a-mediated transcription , we generated MCF-7 cells with knocked down p27 via retroviral delivery of p27 shRNA . Regulation ESR1 NR2F1 17549341 1752493 ( chicken ovalbumin upstream promoter-transcription factor I ) is an orphan nuclear receptor , which is expressed in various tissues and *regulates* the [estrogen receptor (ER)] by competition for DNA binding . Regulation ESR1 TGM2 16548355 1537863 To investigate the *effect* of , which mainly consists of seabuckthorn fatty acid , on serum estrogen and [estrogen receptor (ER)] in multiple target tissues as uterus , liver and bone , in aged female rats , in order to explore its mechanism from the aspects of receptor and cytokines . Regulation ESR1 TNF 17598955 1815898 These data indicate that PGF2alpha , and IFNgamma *regulate* [ERalpha] and ERbeta mRNA expressions in bovine luteal cells . Regulation ESR1 TNF 17967830 1931707 By contrast , the [erythrocyte sedimentation rate (ESR)] declined in *response* to antagonist therapy in GR and PR . TNF antagonist therapy did not promote change in blood leukocyte BLyS mRNA levels in either GR or PR , suggesting that the TNF antagonist associated changes in circulating BLyS protein levels reflected changes in local BLyS production in the affected joints rather than changes in systemic BLyS production . Regulation ESR2 CCND1 23060014 2763555 expression is *involved* in [estrogen receptor beta] ( ERß ) in human prostate cancer . Regulation ESRRA PGC 12522104 1063970 The transcriptional coactivator *regulates* the expression and activity of the orphan nuclear receptor [estrogen related receptor alpha] ( ERRalpha ) . Regulation ESRRA PGC 12522104 1063972 In this study , we show that the transcriptional coactivator , which is implicated in the control of energy metabolism , *regulates* [ERRalpha] at two levels . Regulation ETS1 EPHB2 19567783 2111199 The treatment of HepG2 cells with HGF induced *dependent* phosphorylation of [Ets] , which leads to its activation , before the up-regulation of p16 , suggesting that another factor suppresses Ets activity . Regulation ETS1 PLAU 20645833 2292540 bFGF can enhance the invasion ability of ovarian cancer cells in vitro by inducing the expression of , and this effect is also *regulated* by the transcription factor [Ets-1] . Regulation ETS1 PLAU 8952701 400967 [Ets-1] *regulates* angiogenesis by inducing the expression of and matrix metalloproteinase-1 and the migration of vascular endothelial cells . Regulation ETS1 TNF 11229456 788631 The *effects* of interleukin-1 (IL-1) or on [Ets-1] expression and activation ( DNA binding ) in cultured synovial fibroblasts were analyzed by Western blotting and DNA gel shift assay , respectively . Regulation ETS2 EPHB2 19567783 2111200 The treatment of HepG2 cells with HGF induced *dependent* phosphorylation of [Ets] , which leads to its activation , before the up-regulation of p16 , suggesting that another factor suppresses Ets activity . Regulation ETS2 UCA1 24069250 2847111 Taking into account the anti-apoptosis function of Ets-2 , our data suggested that Ets-2 regulates apoptosis process by regulating the expression of UCA1 , moreover may be *involved* in the activation of Akt signaling pathway by [Ets-2] in bladder cancer cells . Regulation ETV5 MAP2K6 22998872 2679124 Further , the Ets transcription family member [Etv5/Erm] is strongly *regulated* by and Erm overexpression can rescue the gliogenic potential of Mek deleted progenitors . Regulation ETV6 EPHB2 15060146 1230465 These data indicate that [TEL] is a constituent downstream of ERK in signal transduction systems and is physiologically *regulated* by in molecular and biological features . Regulation ETV7 FGF1 19386269 2069580 *regulated* [Etv] genes are essential for repressing Shh expression in mouse limb buds . Regulation ETV7 FGF10 19386269 2069581 *regulated* [Etv] genes are essential for repressing Shh expression in mouse limb buds . Regulation ETV7 FGF11 19386269 2069582 *regulated* [Etv] genes are essential for repressing Shh expression in mouse limb buds . Regulation ETV7 FGF12 19386269 2069583 *regulated* [Etv] genes are essential for repressing Shh expression in mouse limb buds . Regulation ETV7 FGF13 19386269 2069584 *regulated* [Etv] genes are essential for repressing Shh expression in mouse limb buds . Regulation ETV7 FGF14 19386269 2069585 *regulated* [Etv] genes are essential for repressing Shh expression in mouse limb buds . Regulation ETV7 FGF16 19386269 2069586 *regulated* [Etv] genes are essential for repressing Shh expression in mouse limb buds . Regulation ETV7 FGF17 19386269 2069587 *regulated* [Etv] genes are essential for repressing Shh expression in mouse limb buds . Regulation ETV7 FGF18 19386269 2069588 *regulated* [Etv] genes are essential for repressing Shh expression in mouse limb buds . Regulation ETV7 FGF19 19386269 2069589 *regulated* [Etv] genes are essential for repressing Shh expression in mouse limb buds . Regulation ETV7 FGF2 19386269 2069590 *regulated* [Etv] genes are essential for repressing Shh expression in mouse limb buds . Regulation ETV7 FGF20 19386269 2069591 *regulated* [Etv] genes are essential for repressing Shh expression in mouse limb buds . Regulation ETV7 FGF21 19386269 2069592 *regulated* [Etv] genes are essential for repressing Shh expression in mouse limb buds . Regulation ETV7 FGF22 19386269 2069593 *regulated* [Etv] genes are essential for repressing Shh expression in mouse limb buds . Regulation ETV7 FGF23 19386269 2069594 *regulated* [Etv] genes are essential for repressing Shh expression in mouse limb buds . Regulation ETV7 FGF3 19386269 2069595 *regulated* [Etv] genes are essential for repressing Shh expression in mouse limb buds . Regulation ETV7 FGF4 19386269 2069596 *regulated* [Etv] genes are essential for repressing Shh expression in mouse limb buds . Regulation ETV7 FGF5 19386269 2069597 *regulated* [Etv] genes are essential for repressing Shh expression in mouse limb buds . Regulation ETV7 FGF6 19386269 2069598 *regulated* [Etv] genes are essential for repressing Shh expression in mouse limb buds . Regulation ETV7 FGF7 19386269 2069599 *regulated* [Etv] genes are essential for repressing Shh expression in mouse limb buds . Regulation ETV7 FGF8 19386269 2069600 *regulated* [Etv] genes are essential for repressing Shh expression in mouse limb buds . Regulation ETV7 FGF9 19386269 2069601 *regulated* [Etv] genes are essential for repressing Shh expression in mouse limb buds . Regulation ETV7 MTOR 18160036 1838611 While Tel2 deletion did not alter PIKK mRNA levels , in vivo pulse labeling experiments showed that [Tel2] *controls* the stability of ATM and . Regulation EWSR1 GPR115 10322114 612513 Tyrosine kinase Pyk2 mediates *regulation* of the Ewing sarcoma [RNA binding protein EWS] . Regulation EWSR1 GPR132 10322114 612502 Tyrosine kinase Pyk2 mediates *regulation* of the Ewing sarcoma [RNA binding protein EWS] . Regulation EWSR1 GPR87 10322114 612582 Tyrosine kinase Pyk2 mediates *regulation* of the Ewing sarcoma [RNA binding protein EWS] . Regulation EZH2 EPHB2 23116973 2729258 [EZH2] is *regulated* by and targets integrin alpha2 gene to control Epithelial-Mesenchymal Transition and anoikis in colon cancer cells . Regulation EZR CAPN8 22073041 2504385 In addition , [ezrin] , a known calpain substrate that links the plasma membrane to axial actin filaments in microvilli , was cleaved in a *dependent* manner during EHEC infection and lost from its normal locale within microvilli . Regulation F11R TNF 17964041 1820279 Consistent with the previously reported *effects* of on [F11R] expression in cultured endothelial cells , F11R levels correlated strongly with plasma TNF-alpha levels ( r = 0.84 ; p < 0.0001 ) . Regulation F13A1 CAPN8 2883970 73162 These findings suggest that is *responsible* for the intracellular activation of platelet [factor XIII] . Regulation F13B CAPN8 2883970 73176 These findings suggest that is *responsible* for the intracellular activation of platelet [factor XIII] . Regulation F2R APC 12052963 950999 Thus , the prototypical [thrombin receptor] is the *target* for EPCR dependent signaling , suggesting a role for this receptor cascade in protection from sepsis . Regulation F2R APC 14980205 1213857 By using different anti-PARs antibodies and mice with single PAR1 , PAR3 , or PAR4 deletion , we demonstrated that direct neuronal protective *effects* of in vitro and in vivo require [PAR1] and PAR3 . Regulation F2R APEH 16675392 1558859 Here , we show that presenilin and nicastrin prevent tau toxicity by modulating the PI3K/Akt/GSK3beta phosphorylation pathway , whereas *regulates* [aPKC/PAR-1] activities . Regulation F2R ATRX 18842153 1981894 We now report that the SNF2-type chromatin remodeling protein *controls* the expression of eutherian ancestral [PAR1] genes that have translocated to autosomes in the mouse . Regulation F2R BMX 20559570 2279993 *regulates* [proteinase-activated-receptor1 (PAR1)] in breast cancer invasion : signaling partners , hierarchy and physiological significance . Regulation F2R CPB1 9485228 488280 These results imply that prevention of the induced *effects* on the [thrombin receptor] will lessen postoperative morbidity associated with blood transfusion . Regulation F2R CPB2 9485228 488281 These results imply that prevention of the induced *effects* on the [thrombin receptor] will lessen postoperative morbidity associated with blood transfusion . Regulation F2R DAG1 19549170 2103875 Intracellular polarity protein [PAR-1] *regulates* extracellular laminin assembly by regulating the complex . Regulation F2R DLG4 22807451 2660210 The polarity protein [partitioning-defective 1 (PAR-1)] *regulates* dendritic spine morphogenesis through phosphorylating . Regulation F2R EEF1A2 23395513 2818520 The purpose of this study was to explore the expression of KLF2 and PAR-1 in vulnerable plaques of ApoE gene knockout ( ApoE ( -/- ) ) mice and the pharmaceutical *effect* of on the expression of KLF2 and [PAR-1] . Regulation F2R EPHA3 20559570 2279994 *regulates* [proteinase-activated-receptor1 (PAR1)] in breast cancer invasion : signaling partners , hierarchy and physiological significance . Regulation F2R F2RL3 12538843 1050434 Ex vivo platelet aggregation measurements indicated complete [PAR-1] inhibition , as well as an operational *response* . Regulation F2R FADD 15550483 1374890 In endothelial cells transduced with TF to mimic exacerbated TF expression in vascular cells , TF-VIIa-Xa *dependent* activation of [PAR1] remained intact when TF-mediated Xa generation was blocked with 2.5 to 5 nM recombinant TFPI-1 ( rTFPI-1 ) . Regulation F2R IFNG 12182841 977889 In contrast , or LPS did not *affect* the [PAR-1] mRNA expression . Regulation F2R KLF2 23395513 2818521 The purpose of this study was to explore the expression of and PAR-1 in vulnerable plaques of ApoE gene knockout ( ApoE ( -/- ) ) mice and the pharmaceutical *effect* of statin on the expression of KLF2 and [PAR-1] . Regulation F2R MMP9 20422465 2274547 Although matrix metalloproteinase-9 (MMP-9) is involved in cardiomyocytes contractility dysfunction , tissue inhibitor of metalloproteinase-4 ( TIMP-4 ) mitigates the effect of , and [proteinase activated receptor-1] ( PAR-1 , a G-protein couple receptor , GPCR ) is *involved* in the signaling cascade of MMP-9 mediated cardiac dysfunction , the mechanism ( s ) are unclear . Regulation F2R NFKB1 9199198 438642 This study investigates the *role* of the transcription factor in thrombin- and [thrombin receptor] activating peptide ( TRAP , SFLLRNPNDKYEPYF ) -induced mitogenesis of cultured bovine coronary artery smooth muscle cells (SMC) . Regulation F2R PTK2 2153378 127319 Genistein was also able to block the mitogenic effect mediated by thrombin ( IC50 = 20 microM ) although the [thrombin receptor] does not *involve* a activity . Regulation F2R PTK6 2153378 127320 Genistein was also able to block the mitogenic effect mediated by thrombin ( IC50 = 20 microM ) although the [thrombin receptor] does not *involve* a activity . Regulation F2R PTK7 2153378 127321 Genistein was also able to block the mitogenic effect mediated by thrombin ( IC50 = 20 microM ) although the [thrombin receptor] does not *involve* a activity . Regulation F2R RELA 9199198 438643 This study investigates the *role* of the transcription factor in thrombin- and [thrombin receptor] activating peptide ( TRAP , SFLLRNPNDKYEPYF ) -induced mitogenesis of cultured bovine coronary artery smooth muscle cells (SMC) . Regulation F2R SNX1 12058063 952492 To assess SNX1 function , we examined the *effects* of deletion mutants on [PAR1] trafficking . Regulation F2R SNX1 16407403 1527474 We further show that SNX2 , which dimerizes with SNX1 , is not essential for lysosomal sorting of PAR1 , but rather can *regulate* [PAR1] degradation by disrupting endosomal localization of endogenous when ectopically expressed . Regulation F2R SNX2 16407403 1527475 We further show that , which dimerizes with SNX1 , is not essential for lysosomal sorting of PAR1 , but rather can *regulate* [PAR1] degradation by disrupting endosomal localization of endogenous SNX1 when ectopically expressed . Regulation F2R TFAP2A 24297163 2899053 Thus , *regulates* activated [PAR1] signaling by altering receptor surface expression and through recruitment of RGS proteins . Regulation F2R TRADD 15550483 1374888 In endothelial cells transduced with TF to mimic exacerbated TF expression in vascular cells , TF-VIIa-Xa *dependent* activation of [PAR1] remained intact when TF-mediated Xa generation was blocked with 2.5 to 5 nM recombinant TFPI-1 ( rTFPI-1 ) . Regulation F2R TRAF2 15550483 1374889 In endothelial cells transduced with TF to mimic exacerbated TF expression in vascular cells , TF-VIIa-Xa *dependent* activation of [PAR1] remained intact when TF-mediated Xa generation was blocked with 2.5 to 5 nM recombinant TFPI-1 ( rTFPI-1 ) . Regulation F2R WNT1 21331223 2360775 Similarly , [PAR(1)] induced placenta cytotrophoblast physiological invasion process was not *affected* by inhibiting , but was abrogated by siRNA-DvL . Regulation F2R WNT11 21331223 2360776 Similarly , [PAR(1)] induced placenta cytotrophoblast physiological invasion process was not *affected* by inhibiting , but was abrogated by siRNA-DvL . Regulation F2R WNT16 21331223 2360781 Similarly , [PAR(1)] induced placenta cytotrophoblast physiological invasion process was not *affected* by inhibiting , but was abrogated by siRNA-DvL . Regulation F2R WNT2 21331223 2360777 Similarly , [PAR(1)] induced placenta cytotrophoblast physiological invasion process was not *affected* by inhibiting , but was abrogated by siRNA-DvL . Regulation F2R WNT3 21331223 2360778 Similarly , [PAR(1)] induced placenta cytotrophoblast physiological invasion process was not *affected* by inhibiting , but was abrogated by siRNA-DvL . Regulation F2R WNT4 21331223 2360779 Similarly , [PAR(1)] induced placenta cytotrophoblast physiological invasion process was not *affected* by inhibiting , but was abrogated by siRNA-DvL . Regulation F2R WNT6 21331223 2360780 Similarly , [PAR(1)] induced placenta cytotrophoblast physiological invasion process was not *affected* by inhibiting , but was abrogated by siRNA-DvL . Regulation F2R XIAP 23406164 2781029 *dependent* thrombin generation and the resultant [PAR-1] activation serve as an indispensable mechanism to relay the platelet activation process induced by ADP . Regulation F2RL1 IL1B 17339845 1720166 We investigated the *effects* of tumour necrosis factor-alpha (TNF-alpha) , , trypsin and the PAR2 activating peptide , 2-furoyl ( 2f ) -LIGKV-OH on both mRNA and functional expression of [PAR2] in human umbilical vein endothelial cells ( HUVECs ) . Regulation F2RL1 IL1B 19247167 2040712 The expression of [PAR-2] is *regulated* by stimulation . Regulation F2RL1 TNF 17142351 1701010 Flow cytometry for PAR1 , PAR2 , and PAR3 also demonstrated selective [PAR2] upregulation in *response* to and LPS . Regulation F2RL1 TNF 17339845 1720165 We investigated the *effects* of , interleukin-1beta (IL-1beta) , trypsin and the PAR2 activating peptide , 2-furoyl ( 2f ) -LIGKV-OH on both mRNA and functional expression of [PAR2] in human umbilical vein endothelial cells ( HUVECs ) . Regulation F2RL3 F2R 12538843 1050435 Ex vivo platelet aggregation measurements indicated complete inhibition , as well as an operational [PAR-4] *response* . Regulation F3 APOB 2084950 149109 [Tissue factor] activity generated by incubation of a fixed amount of Apo-TF with plasma lipoproteins was concentration *dependent* and saturable . Regulation F3 EGF 16113838 1448781 [Tissue factor] is *regulated* by in normal and malignant human endometrial epithelial cells . Regulation F3 F10 2130929 150678 This article also discusses the role of recombinant factor VIIa in the treatment of factor VIII deficiency patients with acquired factor VIII inhibitors , factor VII and ischemic heart disease and the factor VII-phospholipid complex , and the *regulation* of the [thromboplastin-factor] VIIa complex by and extrinsic pathway inhibitor (EPI) . Regulation F3 F10 2781520 119534 Lipoprotein Associated Coagulation Inhibitor ( LACI ) is a *dependent* inhibitor of the factor [VII(a)/Tissue Factor] catalytic complex . Regulation F3 F10 2807038 121315 The activity of the extrinsic pathway inhibitor (EPI) , which is the *dependent* inhibitor of the factor VIIa-tissue [thromboplastin] complex , was serially determined in 13 patients with postoperative/posttraumatic septicemia , and compared to the activity of antithrombin ( AT ) , heparin cofactor II and protein C ( PC ) . Regulation F3 F7 2130929 150679 This article also discusses the *role* of recombinant in the treatment of factor VIII deficiency patients with acquired factor VIII inhibitors , factor VII and ischemic heart disease and the factor VII-phospholipid complex , and the regulation of the [thromboplastin-factor] VIIa complex by factor Xa and extrinsic pathway inhibitor (EPI) . Regulation F3 GPI 24436371 2912719 Monocyte ß2GPI and [Tissue Factor (TF)] expression and peripheral blood mononuclear cell *response* to <ß2GPI> stimulation were evaluated . Regulation F3 HNF4A 16389552 1539878 *Role* of in control of blood [coagulation factor] gene expression . Regulation F3 IL1A 7676402 326327 [Tissue factor (TF)] can be induced in *response* to stimulation with tumor necrosis factor alpha (TNF-alpha) , and phorbol 12-myristate 13-acetate ( PMA ) . Regulation F3 LPA 2084950 149110 [Tissue factor] activity generated by incubation of a fixed amount of Apo-TF with plasma lipoproteins was concentration *dependent* and saturable . Regulation F3 LRP1 11150722 758950 This possibility became apparent from the observation that is *involved* in down-regulation of [Tissue Factor] expression at the surface of monocytes and fibroblasts . Regulation F3 LRP10 11150722 758947 This possibility became apparent from the observation that is *involved* in down-regulation of [Tissue Factor] expression at the surface of monocytes and fibroblasts . Regulation F3 LRP11 11150722 758948 This possibility became apparent from the observation that is *involved* in down-regulation of [Tissue Factor] expression at the surface of monocytes and fibroblasts . Regulation F3 LRP12 11150722 758949 This possibility became apparent from the observation that is *involved* in down-regulation of [Tissue Factor] expression at the surface of monocytes and fibroblasts . Regulation F3 LRP2 11150722 758951 This possibility became apparent from the observation that is *involved* in down-regulation of [Tissue Factor] expression at the surface of monocytes and fibroblasts . Regulation F3 LRP3 11150722 758952 This possibility became apparent from the observation that is *involved* in down-regulation of [Tissue Factor] expression at the surface of monocytes and fibroblasts . Regulation F3 LRP4 11150722 758953 This possibility became apparent from the observation that is *involved* in down-regulation of [Tissue Factor] expression at the surface of monocytes and fibroblasts . Regulation F3 LRP5 11150722 758954 This possibility became apparent from the observation that is *involved* in down-regulation of [Tissue Factor] expression at the surface of monocytes and fibroblasts . Regulation F3 LRP6 11150722 758955 This possibility became apparent from the observation that is *involved* in down-regulation of [Tissue Factor] expression at the surface of monocytes and fibroblasts . Regulation F3 LRP8 11150722 758956 This possibility became apparent from the observation that is *involved* in down-regulation of [Tissue Factor] expression at the surface of monocytes and fibroblasts . Regulation F3 LYN 18363812 1912736 [Tissue factor] and IL8 production by P-selectin dependent platelet-monocyte aggregates in whole blood *involves* phosphorylation of and is inhibited by IL10 . Regulation F3 TFPI 12028585 947533 [Tissue factor (TF)] is involved in tumor progression and metastatic potency in some malignant tumors and its function is *regulated* by therefore the interaction of both molecules is crucial for their functional role . Regulation F3 TFPI 1423817 202198 [Tissue factor] activity on cell surfaces is largely *regulated* by a plasma inhibitor , . Regulation F3 TFPI 17196206 1821755 [Tissue factor (TF)] is a key mediator of atherosclerotic plaque thrombogenicity and may be *regulated* by plaque . Regulation F3 TFPI 2130929 150677 This article also discusses the role of recombinant factor VIIa in the treatment of factor VIII deficiency patients with acquired factor VIII inhibitors , factor VII and ischemic heart disease and the factor VII-phospholipid complex , and the *regulation* of the [thromboplastin-factor] VIIa complex by factor Xa and . Regulation F3 TNF 2069802 162590 *Effect* of Escherichia coli , Streptococcus agalactiae and on lactoferrin release and the generation of tissue [thromboplastin] . Regulation F7 F3 11243844 792244 is not *involved* in the mitogenic activity of [factor VIIa] . Regulation F8 HES2 9308738 454598 Of particular importance is the fact that with a high in vivo MW *affects* [factor VIII/von] Willebrand factor which can lead to an acquired von Willebrand syndrome . Regulation F9 EPHB2 19255327 2051136 Based on the pivotal *role* of signaling and vascular endothelial growth factor ( VEGF ) in [papillary thyroid cancer (PTC)] , we conducted a phase II clinical trial of sorafenib targeting RAF and VEGF receptor kinases in PTC . Regulation F9 IL1B 12081561 958400 In contrast , a pan-specific TGF-beta neutralizing antibody significantly blocked the *effects* of on [PTC] fibronectin secretion ( IL-1beta , 268.1 +/- 30.6 vs. IL-1beta+alphaTGF-beta 157.9 +/- 14.4 % , of control values , P < 0.001 ) and DNA synthesis ( IL-1beta 81.0 +/- 6.7 % vs. IL-1beta+alphaTGF-beta 93.4 +/- 2.1 % , of control values , P < 0.01 ) . Regulation F9 IL1B 15705185 1372752 The NADPH oxidase inhibitor ( AEBSF ) significantly attenuated all observed deleterious *effects* of on [PTC] . Regulation F9 IL1B 19420104 2120146 In this study , we examined the *effects* of on [proximal tubular cell (PTC)] response to TGF beta . Regulation FABP3 IL1B 10477831 643353 Neither TNF-alpha nor had any significant *effect* on [H-FABP] mRNA expression in heart and muscle . Regulation FABP3 TNF 10477831 643352 Neither nor IL-1beta had any significant *effect* on [H-FABP] mRNA expression in heart and muscle . Regulation FABP4 TNF 8923470 397269 Low level constitutive expression of PPAR gamma in 3T3-L1 adipocytes ( at levels approximately 2- to 3-fold higher than in preadipocytes ) partially blocked the inhibitory *effect* of on [aP2] and adipsin expression . Regulation FADD EPHB2 12122017 984991 Head involution defective ( Hid ) -triggered apoptosis requires caspase-8 but not [FADD] ( Fas associated death domain ) and is *regulated* by in mammalian cells . Regulation FADD TLR7 16709845 1564617 The [Fas associated death domain protein] is required in apoptosis and induced proliferative *responses* in B cells . Regulation FADD TNF 20564232 2290305 Immunoprecipitation studies revealed associations of NM IIB with clathrin , [FADD] , and caspase 8 in *response* to suggesting a role for NM IIB in TNFR1 endocytosis and the formation of the death inducing signaling complex (DISC) . Regulation FAP CLU 22512538 2601997 Overall , our results allow us to postulate a putative protective *role* of in [FAP] , namely in the modulation of TTR aggregate formation . Regulation FAP CLU 22512538 2602000 Future experiments are required to clarify the *role* of in [FAP] . Regulation FAR1 FHL1 18670649 1943275 The transcription of FHY1 and are *controlled* by FHY3 ( Far red elongated HYpocotyl 3 ) and [FAR1] ( FAr red impaired Response 1 ) , a related pair of transcription factors , which thus indirectly control phyA nuclear accumulation . Regulation FAS ABCC6 15138577 1246213 Remarkably , omega-6 PUFAs linoleic acid ( LA ) and , suppressors of both hepatic and adipocytic FAS dependent lipogenesis , had no significant inhibitory *effects* on the activity of tumor associated [FAS] in SK-Br3 breast cancer cells . Regulation FAS ADD1 10585876 571564 Reciprocally , co-transfection of Id3 antisense and ADD1 expression vectors in preadipocytes potentiated the *effect* on the [FAS] promoter activity . Regulation FAS AKT1 15665818 1369584 In T lymphocytes , the *role* of in regulating [Fas/Fas] ligand (FasL) mediated apoptotic signaling and death is not clearly understood . Regulation FAS AKT1 15806173 1417504 Collectively , our findings are consistent with a working model in which activation *regulates* [FAS] expression , at least in part , whereas FAS activity modulates AKT activation . Regulation FAS AKT2 15665818 1369585 In T lymphocytes , the *role* of in regulating [Fas/Fas] ligand (FasL) mediated apoptotic signaling and death is not clearly understood . Regulation FAS AKT2 15806173 1417505 Collectively , our findings are consistent with a working model in which activation *regulates* [FAS] expression , at least in part , whereas FAS activity modulates AKT activation . Regulation FAS AKT3 15665818 1369586 In T lymphocytes , the *role* of in regulating [Fas/Fas] ligand (FasL) mediated apoptotic signaling and death is not clearly understood . Regulation FAS AKT3 15806173 1417506 Collectively , our findings are consistent with a working model in which activation *regulates* [FAS] expression , at least in part , whereas FAS activity modulates AKT activation . Regulation FAS ALOX5 20126469 2207233 Moreover , we found that <5-lipoxygenase (5-LOX)> was *responsible* for the up-regulation of [FAS] by using MK886 ( an inhibitor of 5-LOX ) and 5-LOX small interfering RNA . Regulation FAS ANGPT1 15763944 1352566 Interestingly , the DOX induced up-regulation in Fas ( CD95/APO-1 ) and Fas ligand expression could be blocked by Ang-1 , indicating a pivotal *role* of in DOX induced [Fas] and Fas ligand expression . Regulation FAS ANGPT2 11463364 839185 Using adenoviral overexpression of a dominant negative form of adipocyte determination and differentiation factor 1 ( ADD1 ) , a transcription factor that binds to the insulin-responsive E box , we demonstrated that ADD1 was required for *regulation* of the [FAS] gene in 3T3-L1 adipocytes . Regulation FAS ANGPT2 11463364 839188 In conclusion , this is the first report that *regulates* adipocyte [FAS] gene transcription via insulin response sequences in a glucose dependent manner and that this regulation is mediated at least in part via the ADD1 transcription factor . Regulation FAS APAF1 17603723 1765192 Our results show an in-vivo linkage between [Fas] , p53 and transcription *regulation* . Regulation FAS APCS 18820644 1987674 Taken together , these results indicate that can *regulate* T-cell levels of [CD95L] by releasing PGE ( 2 ) in response to LPS through a TLR4/MyD88 dependent pathway , with consequences for both T cell and their own survival . Regulation FAS ARAP2 23295182 2742069 The *effects* of on [FAs] and Rac1 were dependent on a functional ArfGAP domain . Regulation FAS ATF2 19720122 2163073 Knockdown of c-Fos and ATF-2 by siRNA reflected that c-Fos counteracted the *effect* of on [Fas/FasL] upregulation . Regulation FAS ATF2 21745187 2490077 Knockdown of p38a MAPK and JNK1 , ATF-2 ( activating transcription factor 2 ) and c-Jun by siRNA ( small interfering RNA ) proved that p38a and JNK1/c-Jun pathways were *responsible* for caffeine evoked [Fas/FasL] up-regulation . Regulation FAS ATG10 11167757 763190 The aims of this study were to delineate further the mechanism for increased bone marrow progenitor cell apoptosis in AA and investigate the *effects* of on apoptosis and [Fas-ag] expression . Regulation FAS ATG12 11167757 763193 The aims of this study were to delineate further the mechanism for increased bone marrow progenitor cell apoptosis in AA and investigate the *effects* of on apoptosis and [Fas-ag] expression . Regulation FAS ATG13 11167757 763192 The aims of this study were to delineate further the mechanism for increased bone marrow progenitor cell apoptosis in AA and investigate the *effects* of on apoptosis and [Fas-ag] expression . Regulation FAS ATG14 11167757 763189 The aims of this study were to delineate further the mechanism for increased bone marrow progenitor cell apoptosis in AA and investigate the *effects* of on apoptosis and [Fas-ag] expression . Regulation FAS ATG3 11167757 763191 The aims of this study were to delineate further the mechanism for increased bone marrow progenitor cell apoptosis in AA and investigate the *effects* of on apoptosis and [Fas-ag] expression . Regulation FAS ATG5 11167757 763194 The aims of this study were to delineate further the mechanism for increased bone marrow progenitor cell apoptosis in AA and investigate the *effects* of on apoptosis and [Fas-ag] expression . Regulation FAS ATG7 11167757 763188 The aims of this study were to delineate further the mechanism for increased bone marrow progenitor cell apoptosis in AA and investigate the *effects* of on apoptosis and [Fas-ag] expression . Regulation FAS BCL2 12915385 1129932 These changes in the [Fas-Fas] ligand pathway and mitochondrial apoptosis *regulation* are enhanced by complete suppression of antiapoptotic FADD-like IL-1beta converting enzyme inhibitory protein ( FLIP ) ( from 30.5 to 0.0 % , P < 0.01 ) and Bcl-xL ( from 22.5 to 0.1 % , P = 0.03 ) expression among these cells from the earliest days after gene transfer . Regulation FAS BCL2 15075361 1265798 The antagonism of apoptosis afforded by prosurvival Bcl-2 proteins appeared to be specific for the GCs , as and Bcl-x ( L ) blocked GC-induced apoptosis in T cell hybridomas but did not *affect* [Fas] or activation induced apoptosis . Regulation FAS CA1 15652756 1364366 We conducted this study to evaluate the *effect* of and E-JUR-94013 , two marine fish extracts from S. scombrus and T. trachurus , respectively , on in vitro PBLs activation and on the expression and functionality of [Fas] , a cell surface molecule that plays a central role in immune homeostasis and cytotoxic activity . Regulation FAS CA2 9529322 496616 These results further define the *role* of in perforin and [FasL/Fas] killing and demonstrate that differential Ca2+ signaling can modulate T cell effector functions . Regulation FAS CALM3 23760276 2820157 Previous studies have shown that calmodulin (CaM) is recruited into the DISC in cholangiocarcinoma cells , suggesting a novel *role* of in [Fas] mediated signaling . Regulation FAS CASP1 10602493 574856 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Regulation FAS CASP1 12645856 1069712 The inhibitory effects of rifampicin on apoptosis and activation as well as its *effect* on the expression of [CD95L] and FLIPs were reversed by RU486 , an antagonist of glucocorticoid receptor . Regulation FAS CASP1 16330535 1511983 [Fas] costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and activity . Regulation FAS CASP1 17692455 1800526 [Fas] activation increased intracellular ROS levels in a NADPH oxidase- and *dependent* manner . Regulation FAS CASP1 20138036 2213638 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Regulation FAS CASP1 9045686 416375 Fas associated death domain protein 2 ( FLICE2 ) , an ICE/Ced-3 homologue , is proximally *involved* in [CD95-] and p55 mediated death signaling . Regulation FAS CASP10 10602493 574857 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Regulation FAS CASP10 12645856 1069713 The inhibitory effects of rifampicin on apoptosis and activation as well as its *effect* on the expression of [CD95L] and FLIPs were reversed by RU486 , an antagonist of glucocorticoid receptor . Regulation FAS CASP10 16330535 1511984 [Fas] costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and activity . Regulation FAS CASP10 17692455 1800527 [Fas] activation increased intracellular ROS levels in a NADPH oxidase- and *dependent* manner . Regulation FAS CASP10 20138036 2213639 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Regulation FAS CASP12 10602493 574867 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Regulation FAS CASP12 12645856 1069723 The inhibitory effects of rifampicin on apoptosis and activation as well as its *effect* on the expression of [CD95L] and FLIPs were reversed by RU486 , an antagonist of glucocorticoid receptor . Regulation FAS CASP12 16330535 1511994 [Fas] costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and activity . Regulation FAS CASP12 17692455 1800537 [Fas] activation increased intracellular ROS levels in a NADPH oxidase- and *dependent* manner . Regulation FAS CASP12 20138036 2213649 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Regulation FAS CASP14 10602493 574858 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Regulation FAS CASP14 12645856 1069714 The inhibitory effects of rifampicin on apoptosis and activation as well as its *effect* on the expression of [CD95L] and FLIPs were reversed by RU486 , an antagonist of glucocorticoid receptor . Regulation FAS CASP14 16330535 1511985 [Fas] costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and activity . Regulation FAS CASP14 17692455 1800528 [Fas] activation increased intracellular ROS levels in a NADPH oxidase- and *dependent* manner . Regulation FAS CASP14 20138036 2213640 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Regulation FAS CASP16 10602493 574868 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Regulation FAS CASP16 12645856 1069724 The inhibitory effects of rifampicin on apoptosis and activation as well as its *effect* on the expression of [CD95L] and FLIPs were reversed by RU486 , an antagonist of glucocorticoid receptor . Regulation FAS CASP16 16330535 1511995 [Fas] costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and activity . Regulation FAS CASP16 17692455 1800538 [Fas] activation increased intracellular ROS levels in a NADPH oxidase- and *dependent* manner . Regulation FAS CASP16 20138036 2213650 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Regulation FAS CASP2 10602493 574859 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Regulation FAS CASP2 12645856 1069715 The inhibitory effects of rifampicin on apoptosis and activation as well as its *effect* on the expression of [CD95L] and FLIPs were reversed by RU486 , an antagonist of glucocorticoid receptor . Regulation FAS CASP2 16330535 1511986 [Fas] costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and activity . Regulation FAS CASP2 17692455 1800529 [Fas] activation increased intracellular ROS levels in a NADPH oxidase- and *dependent* manner . Regulation FAS CASP2 20138036 2213641 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Regulation FAS CASP3 10602493 574860 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Regulation FAS CASP3 11441079 833396 The ICAM-1 mediated costimulatory signals in this model resulted in early Th cell proliferation followed by cell death that was partially mediated by [Fas] and *involved* loss of mitochondrial membrane potential , processing of procaspase-9 and -3 , and activation of . Regulation FAS CASP3 12645856 1069716 The inhibitory effects of rifampicin on apoptosis and activation as well as its *effect* on the expression of [CD95L] and FLIPs were reversed by RU486 , an antagonist of glucocorticoid receptor . Regulation FAS CASP3 16330535 1511987 [Fas] costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and activity . Regulation FAS CASP3 17692455 1800530 [Fas] activation increased intracellular ROS levels in a NADPH oxidase- and *dependent* manner . Regulation FAS CASP3 20138036 2213642 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Regulation FAS CASP4 10602493 574861 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Regulation FAS CASP4 12645856 1069717 The inhibitory effects of rifampicin on apoptosis and activation as well as its *effect* on the expression of [CD95L] and FLIPs were reversed by RU486 , an antagonist of glucocorticoid receptor . Regulation FAS CASP4 16330535 1511988 [Fas] costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and activity . Regulation FAS CASP4 17692455 1800531 [Fas] activation increased intracellular ROS levels in a NADPH oxidase- and *dependent* manner . Regulation FAS CASP4 20138036 2213643 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Regulation FAS CASP5 10602493 574862 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Regulation FAS CASP5 12645856 1069718 The inhibitory effects of rifampicin on apoptosis and activation as well as its *effect* on the expression of [CD95L] and FLIPs were reversed by RU486 , an antagonist of glucocorticoid receptor . Regulation FAS CASP5 16330535 1511989 [Fas] costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and activity . Regulation FAS CASP5 17692455 1800532 [Fas] activation increased intracellular ROS levels in a NADPH oxidase- and *dependent* manner . Regulation FAS CASP5 20138036 2213644 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Regulation FAS CASP6 10602493 574863 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Regulation FAS CASP6 12645856 1069719 The inhibitory effects of rifampicin on apoptosis and activation as well as its *effect* on the expression of [CD95L] and FLIPs were reversed by RU486 , an antagonist of glucocorticoid receptor . Regulation FAS CASP6 16330535 1511990 [Fas] costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and activity . Regulation FAS CASP6 17692455 1800533 [Fas] activation increased intracellular ROS levels in a NADPH oxidase- and *dependent* manner . Regulation FAS CASP6 20138036 2213645 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Regulation FAS CASP7 10602493 574864 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Regulation FAS CASP7 12645856 1069720 The inhibitory effects of rifampicin on apoptosis and activation as well as its *effect* on the expression of [CD95L] and FLIPs were reversed by RU486 , an antagonist of glucocorticoid receptor . Regulation FAS CASP7 16330535 1511991 [Fas] costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and activity . Regulation FAS CASP7 17692455 1800534 [Fas] activation increased intracellular ROS levels in a NADPH oxidase- and *dependent* manner . Regulation FAS CASP7 20138036 2213646 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Regulation FAS CASP8 10602493 574865 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Regulation FAS CASP8 12198154 981952 The *involvement* of the death adaptor protein FADD and the apoptosis initiating in [CD95] and TRAIL death signalling has recently been demonstrated by the analysis of the native death inducing signalling complex (DISC) that forms upon ligand induced receptor cross linking . Regulation FAS CASP8 12645856 1069721 The inhibitory effects of rifampicin on apoptosis and activation as well as its *effect* on the expression of [CD95L] and FLIPs were reversed by RU486 , an antagonist of glucocorticoid receptor . Regulation FAS CASP8 16330535 1511992 [Fas] costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and activity . Regulation FAS CASP8 16646028 1557162 [Fas] activation of a proinflammatory program in rheumatoid synoviocytes and its *regulation* by FLIP and signaling . Regulation FAS CASP8 17692455 1800535 [Fas] activation increased intracellular ROS levels in a NADPH oxidase- and *dependent* manner . Regulation FAS CASP8 20138036 2213647 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Regulation FAS CASP8 8681376 370192 *Involvement* of , a novel MORT1/FADD interacting protease , in [Fas/APO-1-] and TNF receptor induced cell death . Regulation FAS CASP9 10602493 574866 Activation of c-Jun N-terminal kinase (JNK) by [Fas] ligation is *dependent* , suggesting that caspases may regulate activators of the JNK pathway . Regulation FAS CASP9 12645856 1069722 The inhibitory effects of rifampicin on apoptosis and activation as well as its *effect* on the expression of [CD95L] and FLIPs were reversed by RU486 , an antagonist of glucocorticoid receptor . Regulation FAS CASP9 16330535 1511993 [Fas] costimulation of naive CD4 T cells is *controlled* by NF-kappaB signaling and activity . Regulation FAS CASP9 17692455 1800536 [Fas] activation increased intracellular ROS levels in a NADPH oxidase- and *dependent* manner . Regulation FAS CASP9 20138036 2213648 A novel role of microtubular cytoskeleton in the dynamics of *dependent* [Fas/CD95] death receptor complexes during apoptosis . Regulation FAS CAV1 21382479 2416032 We found that *regulated* [Fas] signaling and mediated the communication between extrinsic and intrinsic pathways . Regulation FAS CCNB1 15215233 1289135 *Regulation* of activation induced [Fas] ( CD95/Apo-1 ) ligand expression in T cells by the complex . Regulation FAS CD38 17120930 1652192 We evaluated *effects* of dietary , c12-CLA content and gender on carcass composition , FA profile of selected tissues , and expression of [FA synthase (FAS)] and stearoyl-CoA desaturase-1 (SCD) mRNA in adipose tissue . Regulation FAS CD3D 18820644 1987669 We identified the protective factor as prostaglandin E ( 2 ) ( PGE ( 2 ) ) and showed that both APC derived supernatants and PGE ( 2 ) prevented [CD95L] upregulation in T cells in *response* to stimulation , thereby avoiding both AICD and activated T cell killing of target macrophages . Regulation FAS CD3E 18820644 1987670 We identified the protective factor as prostaglandin E ( 2 ) ( PGE ( 2 ) ) and showed that both APC derived supernatants and PGE ( 2 ) prevented [CD95L] upregulation in T cells in *response* to stimulation , thereby avoiding both AICD and activated T cell killing of target macrophages . Regulation FAS CD3G 18820644 1987671 We identified the protective factor as prostaglandin E ( 2 ) ( PGE ( 2 ) ) and showed that both APC derived supernatants and PGE ( 2 ) prevented [CD95L] upregulation in T cells in *response* to stimulation , thereby avoiding both AICD and activated T cell killing of target macrophages . Regulation FAS CD4 16354528 1492521 These data suggest both and CD8+ T-cell compartments , as well as the *regulation* of [CD95] expression on CD8+ T-cells , as targets for further study into obesity 's effects on the immune system . Regulation FAS CD40 10072527 594496 Surprisingly , up-regulation of [Fas] , CD23 , and ICAM-1 was partially independent , and up-regulation of LFA-1 was completely *independent* , of induced NF-kappaB activation . Regulation FAS CD40 12560754 1053744 ligation had no *effect* on cell viability or surface expression of CD54 , CD80 , CD86 or [CD95] . Regulation FAS CD40 22505709 2607756 ligation *plays* an important role in activation of p38MAPK , NF-?B , and [Fas] molecules to initiate proapoptotic signaling . Regulation FAS CD40 8695856 375295 All 6 of the BL cell line B cells upregulate [Fas] in *response* to ligation , and in 4 of the cases they become sensitive to Fas mediated death signals . Regulation FAS CD40 9759836 536512 In addition , SB203580 selectively reduced CD40 induced CD54/ICAM-1 expression , whereas *dependent* expression of CD40 and [CD95/Fas] and four newly defined CD40-responsive genes cIAP2 , TRAF1 , TRAF4/CART and DR3 were unaffected . Regulation FAS CD40LG 9045916 416665 In contrast to B-2 cells , B-1 cells expressed [Fas] at only low levels in *response* to alone or CD40L-CD8alpha + interleukin-4 , and were resistant to Fas mediated apoptosis following these treatments . Regulation FAS CD44 17136494 1678012 Furthermore , AICD induced by CD3 restimulation was inhibited by hyaluronidase as well as by soluble [Fas] , indicating an interaction between membrane bound hyaluronan and the cell surface was *involved* in the up-regulation of FasL expression on T cells and subsequent AICD . Regulation FAS CD74 19968579 2185048 This review describes CD74 protein biology with the emphasis on the *role* of in tumor survival and its new role in regulation of the [Fas] death receptor . Regulation FAS CD8A 16354528 1492522 These data suggest both CD4+ and T-cell compartments , as well as the *regulation* of [CD95] expression on CD8+ T-cells , as targets for further study into obesity 's effects on the immune system . Regulation FAS CD8A 9045916 416666 In contrast to B-2 cells , B-1 cells expressed [Fas] at only low levels in *response* to CD40L-CD8alpha alone or + interleukin-4 , and were resistant to Fas mediated apoptosis following these treatments . Regulation FAS CD8B 16354528 1492523 These data suggest both CD4+ and T-cell compartments , as well as the *regulation* of [CD95] expression on CD8+ T-cells , as targets for further study into obesity 's effects on the immune system . Regulation FAS CD8B 9045916 416667 In contrast to B-2 cells , B-1 cells expressed [Fas] at only low levels in *response* to alone or CD40L-CD8alpha + interleukin-4 , and were resistant to Fas mediated apoptosis following these treatments . Regulation FAS CDK1 15215233 1289136 *Regulation* of activation induced [Fas] ( CD95/Apo-1 ) ligand expression in T cells by the cyclin complex . Regulation FAS CFLAR 17112511 1676715 We have reported recently that K8/K18-free hepatocytes from K8-null mice are more sensitive to Fas mediated apoptosis , in line with an increased [Fas] density at the cell surface and an altered *regulation* of the anti-apoptotic ERK1/2 signaling pathway . Regulation FAS CLN3 19536420 2098966 The neuroprotection conferred with CLN pre-treatment was reduced with the Fas ligand (FasL) binding antibody Nok1 , suggesting that the *effects* of may involve a [Fas] : soluble FasL interaction . Regulation FAS CLN5 19536420 2098967 The neuroprotection conferred with CLN pre-treatment was reduced with the Fas ligand (FasL) binding antibody Nok1 , suggesting that the *effects* of may involve a [Fas] : soluble FasL interaction . Regulation FAS CLN6 19536420 2098968 The neuroprotection conferred with CLN pre-treatment was reduced with the Fas ligand (FasL) binding antibody Nok1 , suggesting that the *effects* of may involve a [Fas] : soluble FasL interaction . Regulation FAS CLN8 19536420 2098969 The neuroprotection conferred with CLN pre-treatment was reduced with the Fas ligand (FasL) binding antibody Nok1 , suggesting that the *effects* of may involve a [Fas] : soluble FasL interaction . Regulation FAS CLN9 19536420 2098970 The neuroprotection conferred with CLN pre-treatment was reduced with the Fas ligand (FasL) binding antibody Nok1 , suggesting that the *effects* of may involve a [Fas] : soluble FasL interaction . Regulation FAS CNR1 15864349 1401337 In the hypothalamus , where FAS inhibitors elicit anorexia , SREBP-1c and [FAS] expression are similarly *affected* by ligands . Regulation FAS CTSS 17950288 1820030 Cysteine are not *involved* in [Fas/CD95] signalling in primary skin fibroblasts . Regulation FAS DAXX 11193028 761661 [Fas] also activates a caspase independent pathway which correlates with Fas induced translocation of Daxx from the nucleus to the cytoplasm and *involves* the interaction of with Fas and Ask1 . Regulation FAS DAXX 14517282 1147340 In this study , we investigated the *role* of in [Fas-] and stress induced apoptosis by small interfering RNA mediated Daxx silencing in mammalian cells . Regulation FAS EGF 11064454 746890 Several observations also indicate that the *effects* of on [FAS] expression are ultimately mediated by SREBPs . Regulation FAS EGFR 17182072 1695222 Furthermore , treatment with kinase inhibitors of EGFR and ErbB-2 suggested that activation was *involved* in EGF induced [FAS] expression . Regulation FAS EGFR 17689285 1882300 Although inhibitors did not *affect* the expression of [Fas] , the Fas associated death domain protein , or procaspase-8 in OSCC cells , the inhibition downregulated cellular FLICE-inhibitory protein ( c-FLIP ) . Regulation FAS EGFR 22182753 2543322 Then the *role* of in activating [CD95] death receptor in liver parenchymal cells ( PC ) and hepatic stellate cells (HSC) , which represent a liver stem/progenitor cell compartment , is described summarizing different ways of CD95- and EGFR dependent signaling in the liver . Regulation FAS ERBB2 15172638 1253961 Taken together , the results presented here suggest that *regulates* [FAS] expression in HNSCC and point out Ki-67 as a useful prognostic marker for these tumors . Regulation FAS ERBB2 17182072 1695223 Furthermore , treatment with kinase inhibitors of EGFR and ErbB-2 suggested that activation was *involved* in EGF induced [FAS] expression . Regulation FAS FADD 12198154 981953 The *involvement* of the death adaptor and the apoptosis initiating caspase-8 in [CD95] and TRAIL death signalling has recently been demonstrated by the analysis of the native death inducing signalling complex (DISC) that forms upon ligand induced receptor cross linking . Regulation FAS FAF1 11101154 755976 Human Fas associated factor 1 protein ( ) is *involved* in the positive regulation of [Fas] signaling even though it can not initiate the signal for itself . Regulation FAS FAS 10395739 627572 Therefore , these results suggest that mediated phospholipase D activation may be a consequence of primary stimulation of phosphatidylcholine-specific phospholipase C and that phospholipase D may *play* a role in [Fas] cross linking signaling downstream from phosphatidylcholine-specific phospholipase C . Regulation FAS FAS 10715265 676430 The biological consequences of activation in cardiomyocytes and the *regulation* of [Fas] and FasL abundance in the myocardium in vivo remain largely unknown . Regulation FAS FAS 11713312 881097 FAS2-lacZ fusion constructs deleted for this region showed high reporter gene expression even in the absence of FAS1 , arguing for a negatively acting downstream repression site ( DRS ) responsible for *dependent* expression of [FAS2] . Regulation FAS FAS 15353567 1292890 Balanced levels of subunits alpha and beta are ensured by an autoregulatory *effect* of on [FAS2] expression and by posttranslational degradation of excess FAS subunits . Regulation FAS FAS 15607568 1356958 Taking into account that the inhibitory *effect* of on the expression of [FAS] in cultured hepatocytes has been shown to be related to a non-specific peroxidative mechanism , a similar GLA dependent FAS regulatory mechanism involving peroxidative products may occur in normal and neoplastic tissues . Regulation FAS FAS 17996681 1821735 The Jurkat cells were transfected with Fas-ASODN using lipofectin , and the *effects* of on [Fas] mRNA level , Fas expression on T cells surface , and apoptosis were investigated by RT-PCR , FCM and co-culture assay , respectively . Regulation FAS FAS 8463228 215825 Glucose , at physiologic concentrations and in the absence of hormones , appears to *regulate* [FAS] gene expression in HepG2 cells predominantly by mediating mRNA stability . Regulation FAS FAS 8598462 350713 Surface T cell [Fas] *regulation* , in vivo activation , and apoptosis . Regulation FAS FAS 9697835 524734 Taken together , these data suggest that [Fas] has a novel role in the regulation of myelopoiesis and that may *act* as a tumor suppressor to control leukemogenic transformation in myeloid progenitor cells . Regulation FAS FASLG 10699948 672127 Our data indicate that ET-18-OCH ( 3 ) induces apoptosis via Fas after the ether lipid is inside the cell , and this [Fas] activation is *independent* of the interaction of Fas with its natural ligand . Regulation FAS FASLG 10812970 693223 Cleavage of membrane bound to a soluble form ( sFasL ) does not *affect* its ability to bind to [Fas] but drastically decreases its cytotoxic activity . Regulation FAS FASLG 14630709 1188075 Altogether , our results highlight the putative *role* of both membrane bound and soluble in oxLDL induced [Fas] and FADD dependent apoptosis of T lymphocytes and suggest an involvement of ROS , ERK , and JNK in this process . Regulation FAS FASLG 15033908 1244017 To determine whether beta-cells can modulate their sensitivity to apoptosis at the level of Fas , we investigated the *effect* of on surface expression of [Fas] in NIT-1 insulinoma cells from nonobese diabetic (NOD) mice prone to autoimmune diabetes and islet cells from NOD and nonautoimmune BALB/c mice . Regulation FAS FASLG 19902128 2161765 In this study , we tried to investigate the *effects* of on [Fas] expression and on the apoptosis of nucleus pulposus ( NP ) cells in Sprague-Dawley rats . Regulation FAS FASLG 20616204 2316303 It is hypothesized that following co-exposure , germ cells adapt to the lack of Sertoli cell support by reducing the [Fas] *response* to normal signals . Regulation FAS FASLG 9455798 484473 Melanoma cells expressed both [Fas] and FasL , but killing of melanoma cells did not *involve* interactions . Regulation FAS FFAR4 24997608 2952759 We reported that Gpr120 is the functional receptor for these fatty acids and that [?-3-FAs] produce robust anti-inflammatory , insulin sensitizing effects , both in vivo and in vitro , in a *dependent* manner . Regulation FAS FOXP3 21746966 2461752 Our study reveals that negatively *regulates* [CD95L] expression in Tregs and demonstrates that Tregs are susceptible to homeostatic control by CD95 stimulation . Regulation FAS FXR1 16957179 1646607 Thus , we have identified a novel IR-1 in the FAS promoter and demonstrate that it mediates acid *regulation* of the [FAS] gene . Regulation FAS FXR2 16957179 1646608 Thus , we have identified a novel IR-1 in the FAS promoter and demonstrate that it mediates acid *regulation* of the [FAS] gene . Regulation FAS GNRH1 10084591 599204 The aims of this study were to determine whether the [FAS] *response* to is also decreased at fast frequencies of GnRH stimulation and whether FAS is superior to LH as a marker of GnRH secretory activity at fast-pulse frequencies . Regulation FAS GNRH1 10690855 670431 The [FAS] *responses* to both conventional and high dose were within the normal range . Regulation FAS GNRH1 16461985 1522792 The absence of day/night differences in FAS suggests that *plays* a more prominent role in [FAS] regulation than does thyrotropin releasing hormone in PMW . Regulation FAS GRAP2 15601669 1375281 By using specific inhibitors for each MAPK , we confirmed the pivotal role of the IkappaB/NF-kappaB system by demonstrating that ERKs , , and JNK are not *involved* in [Fas] up-regulation by TNF-alpha . Regulation FAS HLA-DRB1 16800817 1612723 HNF-4alpha transactivates reporter constructs containing the distal FAS promoter in a *dependent* manner , and this DR-1 is required for full glucose induction of the [FAS] promoter in primary hepatocytes . Regulation FAS HRG 17539658 1762287 Treatment of MCF-7 cells with EGCG markedly inhibited *dependent* induction of mRNA and protein of [FAS] . Regulation FAS HSD17B8 19571038 2149710 Notably , 17beta-HSD8 was previously classified as a steroid metabolizing enzyme , but our data suggest that <17beta-HSD8> is primarily *involved* in mitochondrial [FAS] . Regulation FAS IFNA2 14696459 1180333 The in vitro *effect* of on [CD95] expression of T cells in hepatitis B . Regulation FAS IFNA2 14696459 1180334 We aimed to investigate Fas ( CD95 ) expression of peripheral cytotoxic T cells and to show the in vitro *effect* of on [Fas] expression and apoptosis . Regulation FAS IFNA2 16109525 1445268 The aim of this study was to explore the *effect* of on [Fas] expression and the apoptosis rate of peripheral blood cytotoxic T cells ( CTLs ) in patients with hepatitis B . Regulation FAS IFNB1 15748896 1379408 Pretreatment with anti-CD95-L mAb partially prevented the IFN-beta induced loss of delta psi m , suggesting that the interaction of *regulated* [CD95] with CD95-L plays a crucial role in the induction of fratricide . Regulation FAS IFNG 10514014 651527 Administration of Propionibacterium acnes ( P. acnes ) upregulated functional [Fas] expression on macrophages in an *dependent* manner , and these macrophages became competent to secrete mature IL-18 upon stimulation with FasL . Regulation FAS IFNG 10516755 652343 *Regulation* of [CD95] expression and CD95 mediated cell death by in acute lymphoblastic leukemia with chromosomal translocation t ( 4 ; 11 ) . Regulation FAS IFNG 10516755 652344 The regulatory *effects* of on [CD95] expression and CD95 mediated cell death were investigated in three high-risk pro-B acute lymphoblastic leukemia ( ALL ) lines that carry the chromosomal translocation t ( 4 ; 11 ) ( q21 ; q23 ) . Regulation FAS IFNG 10576768 569499 However , in contrast to results of recent in vitro studies , in the BB/W rat [Fas/FasL] expression is not *regulated* by IL-2 , -4 , -6 , -10 , -12 , , and tumor necrosis factor alpha . Regulation FAS IFNG 11739498 886508 Moreover , an in vivo blockade of TNF-alpha preferentially inhibited the production of IFN-gamma and blocked *dependent* up-regulation of [Fas] ; Regulation FAS IFNG 12480581 1024220 To investigate *effect* of on [Fas] expression and Fas mediated apoptosis in tumor cell lines . Regulation FAS IFNG 12484048 1024851 However , did not *affect* the expression of [Fas] in HuH28 cells . Regulation FAS IFNG 15123769 1272989 We investigated the *effect* of recombinant on proliferation , [Fas/Fas] ligand (FasL) expression , and apoptosis in allergen stimulated peripheral blood mononuclear cells obtained from atopic , asthmatic patients and nonatopic , control subjects . Regulation FAS IFNG 15240678 1270200 Thus , both *dependent* induction of [Fas/FasL] and IFN-gamma independent induction of perforin contribute to CTL mediated elimination of host B cells in AGVHD . Regulation FAS IFNG 7538820 306906 [Fas] antigen expression on lymphocytes is *regulated* by and tumor necrosis factor alpha (TNF alpha) , cytokines that also have inhibitory effects on hematopoiesis . Regulation FAS IFNG 7542501 314120 and TNF-alpha had a synergistic *effect* on the induction of [Fas] , when both cytokines were added to the culture . Regulation FAS IFNG 9485203 488250 Furthermore , macrophages infected with L. major in vitro up-regulate their surface expression of [Fas] in *response* to and as a result become susceptible to CD4+ T cell induced apoptotic death . Regulation FAS IFNG 9935158 589543 In human primary cell lines from a squamous cell carcinoma (SCC) of the vulva , the *effect* of cisplatin ( CDDP ) and on the expression of [CD95L] and its 2 receptor isoforms , CD95 transmembrane (CD95tm) and CD95 soluble receptor , was studied at the mRNA and protein levels . Regulation FAS IGF1 18653623 1967112 did not *affect* Fas expression or activation by [anti-Fas] of caspase-8 , but inhibited the depolarization of the mitochondrial membrane . Regulation FAS IGF1 7511375 250075 We have investigated *regulation* of [FAS] by transfecting into 3T3-L1 fibroblasts chimeric genes comprising the 5'-flanking region of the FAS gene linked to a luciferase ( LUC ) reporter gene . Regulation FAS IGF1 7511375 250076 The half-maximal *effect* of on [FAS] promoter activity was observed at 3 nM and a maximal effect was reached at 10 nM . Regulation FAS IGF1 7511375 250077 Furthermore , sequences responsible for *regulation* of the [FAS] gene are located within the proximal promoter between nucleotides -67 and -19 of the FAS gene . Regulation FAS IL10 15309723 1285012 To investigate the *effects* of platelet derived growth factor ( PDGF ) and on [Fas/Fas-ligand] and Bcl-2/Bax mRNA expressions in rat hepatic stellate cells . Regulation FAS IL10 17105443 1645083 The *effects* of on the expression of [Fas] and FasL in rat hepatic stellate cells . Regulation FAS IL10 17199973 1663132 IL-1beta and had no significant *effect* on the basal [Fas] mRNA expressions in both GES-1 and AGS cells ( all P > 0.05 ) . Regulation FAS IL12A 11877485 919109 In contrast , CD4 ( + ) CD1d restricted NKT cells potently produced both Th1 and Th2 cytokines , up-regulated perforin in *response* to stimulation by phorbol myristate acetate and ionomycin but not IL-2 or , and could be induced to express [CD95L] . Regulation FAS IL12B 11877485 919110 In contrast , CD4 ( + ) CD1d restricted NKT cells potently produced both Th1 and Th2 cytokines , up-regulated perforin in *response* to stimulation by phorbol myristate acetate and ionomycin but not IL-2 or , and could be induced to express [CD95L] . Regulation FAS IL1B 17199973 1663133 and IL-10 had no significant *effect* on the basal [Fas] mRNA expressions in both GES-1 and AGS cells ( all P > 0.05 ) . Regulation FAS IL2 10576768 569500 However , in contrast to results of recent in vitro studies , in the BB/W rat [Fas/FasL] expression is not *regulated* by , -4 , -6 , -10 , -12 , interferon gamma , and tumor necrosis factor alpha . Regulation FAS IL2 10629645 576436 We designed a prospective pilot study to evaluate in vivo *effects* of low dose and IFN-alpha combination on expression of Bcl-2 , [FAS] ( Apo-1/CD 95 ) , Fas Ligand , IL-2 receptor ( CD25 ) , and HLA-DR on peripheral lymphocytes in patients with advanced renal cell carcinoma . Regulation FAS IL2 11877485 919111 In contrast , CD4 ( + ) CD1d restricted NKT cells potently produced both Th1 and Th2 cytokines , up-regulated perforin in *response* to stimulation by phorbol myristate acetate and ionomycin but not or IL-12 , and could be induced to express [CD95L] . Regulation FAS IL3 10951571 723697 *Involvement* of p53 and in the up-regulation of [CD95] ( APO-1/Fas ) by X-ray irradiation . Regulation FAS IL4 21534013 2444613 *Effect* of IFN-? and levels on the expression of [Fas] and Bcl-2 in peripheral blood lymphocytes in hemodialysis patients . Regulation FAS IL4 9045916 416668 In contrast to B-2 cells , B-1 cells expressed [Fas] at only low levels in *response* to CD40L-CD8alpha alone or CD40L-CD8alpha + , and were resistant to Fas mediated apoptosis following these treatments . Regulation FAS IL6 11140882 760403 *Effect* of endogenous on [Fas] ( APO-1/CD95 ) receptor expression in advanced melanoma patients . Regulation FAS IL7 17404319 1722059 The potential *role* of in [Fas] up-regulation in vivo was verified in IL-7 treated macaques and in HIV infected or chemotherapy treated patients by the correlation between serum IL-7 levels and Fas expression on T cells . Regulation FAS INS 10103003 602435 Transient transfection experiments using FAS promoter constructs deleted for FIRE2 and FIRE3 demonstrate that neither of these elements mediates the *response* of the [FAS] promoter in the rat hepatoma cell line H4IIE , however , ICE at -103/-87 is responsible for mediating the effect of the insulin antagonist cAMP . Regulation FAS INS 10103003 602436 The hFIRE element located at -57/-34 , in spite of its role in the glucose/insulin response in primary rat hepatocytes , is apparently not involved in the *regulation* of the rat [FAS] promoter in H4IIE cells . Regulation FAS INS 10698960 672068 Although diazoxide ( 5 microM ) alone did not change FAS activity in cultured 3T3-L1 adipocytes , it significantly attenuated 's *effect* on [FAS] activity ( P < 0.001 ) . Regulation FAS INS 10744693 680672 We also demonstrated that the -65 E-box is required for *regulation* of the [FAS] promoter using 3T3-L1 adipocytes in culture . Regulation FAS INS 10744693 680674 This study demonstrates that the sequence requirement for FAS gene regulation employing an in vitro culture system does not reflect the in vivo situation and that two 5'-flanking regions are required for proper nutritional and *regulation* of the [FAS] gene . Regulation FAS INS 11374539 817881 These results suggest that serine/threonine dephosphorylation and protein kinase A-dependent pathways are involved in the *regulation* of [FAS] gene expression by , but MAP kinase is probably not involved . Regulation FAS INS 11533263 854664 The purpose of the current study was to examine the *role* of in this exercise down-regulation of [FAS] . Regulation FAS INS 11919653 926058 In this cell line , a low concentration of troglitazone ( 250 nM ) increased the *effect* of on the [FAS] promoter activity and the expression of FAS protein about 1.5- to 2-fold . Regulation FAS INS 11919653 926059 Since the *effect* of on the expression of [FAS] is believed to be mediated by activation of protein kinase B (PKB) , we investigated the effect of troglitazone on the regulation of PKB . Regulation FAS INS 15607569 1356964 Strikingly , *regulated* stimulation of [FAS] expression in adipose cells is also mediated by the PI-3'K pathway with AKT being involved as a downstream effector . Regulation FAS INS 16054098 1438810 Failure of insulin to acutely reduce hepatic FAS activity in hyperinsulinemic mice , including L-SACC1 transgenics with liver inactivation of CEACAM1 , and Ob/Ob obese mice , suggests that the acute *effect* of on [FAS] activity depends on the prior insulinemic state . Regulation FAS INS 18079124 1868209 Rat hepatocytes transfected with an adenovirus encoding a dominant negative form of PPARalpha were resistant to the stimulatory *effects* of on [Fas] and Scd-1 mRNA expression in vitro . Regulation FAS INS 18682535 1973398 We show that both T ( 3 ) and *regulate* [FAS] transcription via this sequence . Regulation FAS INS 20219977 2243563 GHRP-6 treatment increased FAS and glucose transporter-4 gene expression and potentiated 's *effect* on epididymal fat mass , adipocyte size ( P < 0.001 ) , [FAS] ( P < 0.001 ) , and glucose transporter-4 ( P < 0.05 ) . Regulation FAS INS 2535847 105756 Furthermore , the *effect* of on the [FAS] mRNA level was abolished by cycloheximide administration . Regulation FAS INS 7836367 293633 Using this system we found a direct *effect* of on GAPDH and [FAS] gene expression in rat adipocytes . Regulation FAS INS 8093078 272056 Transient transfection of human and rat hepatoma cell lines with successively deleted FAS/CAT promoter fusion plasmids was used to determine the *effect* of on [FAS] promoter activity . Regulation FAS INS 8119899 250640 Thus , we have identified novel cis acting DNA sequences responsible for *regulation* of the [FAS] gene , which interact with nuclear protein ( s ) from liver and adipocytes and which are found to share limited homology to insulin response sequences present in other genes . Regulation FAS INS 8318007 223055 In order to identify sequences responsible for *regulation* of the [FAS] gene , chimaeric constructs containing serial deletions of the 5'-flanking region of the rat FAS gene ligated to the chloramphenicol acetyltransferase (CAT) reporter gene were prepared and transfected into 3T3-L1 cells . Regulation FAS INS 8318007 223056 These results indicate that sequences responsible for *regulation* of [FAS] gene are also located within 332 bp of the transcription start site . Regulation FAS INS 9644037 514522 In addition , run-on transcription assays and measurements of RNA half-life were performed to determine the controlled step in [FAS] gene *regulation* by . Regulation FAS INS 9738010 531724 Binding of upstream stimulatory factors to the -65 E-box is functionally required for *regulation* of the [FAS] promoter . Regulation FAS JUN 11733515 904578 *Regulation* of [Fas] expression by STAT3 and is mediated by phosphatidylinositol 3-kinase-AKT signaling . Regulation FAS JUN 19927299 2190299 Knock-down of c-Fos and c-Jun protein expression by siRNA suggested that c-Fos counteracted the *effect* of on [Fas/FasL] up-regulation . Regulation FAS JUN 20683948 2299061 The core protein also suppresses apoptosis mediated by Fas ligand because of *dependent* [Fas] down-regulation . Regulation FAS KLRAP1 11418624 830229 In addition , engagement of selectively inhibited TCR induced Fas ligand expression whereas TCR induced [Fas] expression was not significantly *affected* . Regulation FAS LPA 15661236 1365060 In this study , we observed the *effect* of on [Fas] expression and function in ovarian cancer cells . Regulation FAS LTB 20126469 2207235 Collectively , HBxDelta127 promotes cell growth through a positive feedback loop involving 5-LOX and FAS , in which released is *involved* in the up-regulation of [FAS] . Regulation FAS LUM 15623759 1358496 The present study was undertaken to investigate the *role* of in regulating [Fas] and its impact on inflammation and healing of corneal injuries . Regulation FAS MAP3K5 11096076 780069 Thus , the antiapoptotic interaction of QRS with is *controlled* positively by the cellular concentration of Gln and negatively by [Fas] ligation . Regulation FAS MAP3K5 11193028 761662 [Fas] also activates a caspase independent pathway which correlates with Fas induced translocation of Daxx from the nucleus to the cytoplasm and *involves* the interaction of Daxx with Fas and . Regulation FAS MAPK1 21745187 2490065 Knockdown of p38a MAPK and JNK1 , ATF-2 ( activating transcription factor 2 ) and c-Jun by siRNA ( small interfering RNA ) proved that p38a and JNK1/c-Jun pathways were *responsible* for caffeine evoked [Fas/FasL] up-regulation . Regulation FAS MAPK10 21745187 2490066 Knockdown of p38a MAPK and JNK1 , ATF-2 ( activating transcription factor 2 ) and c-Jun by siRNA ( small interfering RNA ) proved that p38a and JNK1/c-Jun pathways were *responsible* for caffeine evoked [Fas/FasL] up-regulation . Regulation FAS MAPK11 21745187 2490067 Knockdown of p38a MAPK and JNK1 , ATF-2 ( activating transcription factor 2 ) and c-Jun by siRNA ( small interfering RNA ) proved that p38a and JNK1/c-Jun pathways were *responsible* for caffeine evoked [Fas/FasL] up-regulation . Regulation FAS MAPK12 21745187 2490068 Knockdown of p38a MAPK and JNK1 , ATF-2 ( activating transcription factor 2 ) and c-Jun by siRNA ( small interfering RNA ) proved that p38a and JNK1/c-Jun pathways were *responsible* for caffeine evoked [Fas/FasL] up-regulation . Regulation FAS MAPK13 21745187 2490069 Knockdown of p38a MAPK and JNK1 , ATF-2 ( activating transcription factor 2 ) and c-Jun by siRNA ( small interfering RNA ) proved that p38a and JNK1/c-Jun pathways were *responsible* for caffeine evoked [Fas/FasL] up-regulation . Regulation FAS MAPK14 21745187 2490070 Knockdown of p38a MAPK and JNK1 , ATF-2 ( activating transcription factor 2 ) and c-Jun by siRNA ( small interfering RNA ) proved that p38a and JNK1/c-Jun pathways were *responsible* for caffeine evoked [Fas/FasL] up-regulation . Regulation FAS MAPK15 21745187 2490064 Knockdown of p38a MAPK and JNK1 , ATF-2 ( activating transcription factor 2 ) and c-Jun by siRNA ( small interfering RNA ) proved that p38a and JNK1/c-Jun pathways were *responsible* for caffeine evoked [Fas/FasL] up-regulation . Regulation FAS MAPK3 21745187 2490071 Knockdown of p38a MAPK and JNK1 , ATF-2 ( activating transcription factor 2 ) and c-Jun by siRNA ( small interfering RNA ) proved that p38a and JNK1/c-Jun pathways were *responsible* for caffeine evoked [Fas/FasL] up-regulation . Regulation FAS MAPK4 21745187 2490072 Knockdown of p38a MAPK and JNK1 , ATF-2 ( activating transcription factor 2 ) and c-Jun by siRNA ( small interfering RNA ) proved that p38a and JNK1/c-Jun pathways were *responsible* for caffeine evoked [Fas/FasL] up-regulation . Regulation FAS MAPK6 21745187 2490073 Knockdown of p38a MAPK and JNK1 , ATF-2 ( activating transcription factor 2 ) and c-Jun by siRNA ( small interfering RNA ) proved that p38a and JNK1/c-Jun pathways were *responsible* for caffeine evoked [Fas/FasL] up-regulation . Regulation FAS MAPK7 21745187 2490074 Knockdown of p38a MAPK and JNK1 , ATF-2 ( activating transcription factor 2 ) and c-Jun by siRNA ( small interfering RNA ) proved that p38a and JNK1/c-Jun pathways were *responsible* for caffeine evoked [Fas/FasL] up-regulation . Regulation FAS MAPK8 21745187 2490075 Knockdown of p38a MAPK and JNK1 , ATF-2 ( activating transcription factor 2 ) and c-Jun by siRNA ( small interfering RNA ) proved that p38a and JNK1/c-Jun pathways were *responsible* for caffeine evoked [Fas/FasL] up-regulation . Regulation FAS MAPK9 21745187 2490076 Knockdown of p38a MAPK and JNK1 , ATF-2 ( activating transcription factor 2 ) and c-Jun by siRNA ( small interfering RNA ) proved that p38a and JNK1/c-Jun pathways were *responsible* for caffeine evoked [Fas/FasL] up-regulation . Regulation FAS MED1 22665482 2632834 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED10 22665482 2632829 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED11 22665482 2632832 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED13 22665482 2632816 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED13L 22665482 2632817 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED14 22665482 2632821 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED15 22665482 2632810 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED16 22665482 2632812 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED17 22665482 2632823 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED18 22665482 2632828 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED19 22665482 2632831 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED20 22665482 2632811 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED21 22665482 2632808 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED22 22665482 2632809 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED23 22665482 2632822 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED24 22665482 2632818 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED25 22665482 2632830 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED26 22665482 2632824 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED27 22665482 2632825 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED29 22665482 2632820 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED30 22665482 2632819 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED31 22665482 2632827 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED4 22665482 2632813 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED6 22665482 2632814 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED7 22665482 2632826 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MED8 22665482 2632815 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS MLXIPL 16184193 1462210 The aim of our study was to assess the *role* of in the control of L-PK and [FAS] gene expression by PUFAs . Regulation FAS MSN 14676203 1211110 We have previously shown that was not *involved* in the binding to [CD95] . Regulation FAS MYLIP 23645835 2795899 These results indicate that may be *involved* in the pathogenesis of ALPS by targeting [Fas] and may therefore serve as a novel therapeutic target . Regulation FAS MYLIP 24924176 2941942 Our investigations show that [Fas] expression in osteosarcoma cells is *regulated* epigenetically by the micro-RNA , encoded by the miR-17-92 cluster . Regulation FAS NFKB1 10072527 594497 Surprisingly , up-regulation of [Fas] , CD23 , and ICAM-1 was partially independent , and up-regulation of LFA-1 was completely *independent* , of CD40 induced activation . Regulation FAS NFKB1 10092091 600397 *regulates* [Fas/APO-1/CD95-] and TCR- mediated apoptosis of T lymphocytes . Regulation FAS NFKB1 10640741 660636 STAT-1alpha and activation are *involved* in IFN-gamma- or TNF-alpha mediated [Fas] up-regulation in microglia , respectively . Regulation FAS NFKB1 10671224 666702 T cell activation induced and HIV tat enhanced [CD95] ( APO-1/Fas ) ligand transcription *involves* . Regulation FAS NFKB1 15143063 1267524 *dependent* induction of tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) and [Fas/FasL] is crucial for efficient influenza virus propagation . Regulation FAS NFKB1 15601669 1375276 We studied the *role* of the transcription factor and of MAPKs in regulating [Fas] expression . Regulation FAS NFKB1 15619676 1357668 The *involvement* of in the regulation of [Fas] by RANKL was analyzed by luciferase assay and EMSA . Regulation FAS NFKB1 16103877 1489007 The *involvement* of and YY1 in the regulation of [Fas] expression was corroborated by the use of Ramos cells with a dominant-active inhibitor of NF-kappaB ( Ramos IkappaB-estrogen receptor (ER) mutant ) and by silencing YY1 with YY1 siRNA , respectively . Regulation FAS NFKB1 16317104 1526236 Epstein-Barr virus ( EBV ) induces CD95 expression and the [CD95] gene ( FAS ) is *regulated* by , STAT1 , and/or p53 . Regulation FAS NFKB1 16330535 1511996 [Fas] costimulation of naive CD4 T cells is *controlled* by signaling and caspase activity . Regulation FAS NFKB1 17291719 1725812 Caspase mediated activation of and ERKs were *involved* in [CD95L-] and TRAIL induced up-regulation of proinflammatory genes in Colo357-BclxL cells . Regulation FAS NFKB1 17786316 1790933 The inverse activities of [Fas] and FasL promoter in tumor cells are *regulated* by , which inhibits Fas expression and increases FasL expression through binding to their respective promoters . Regulation FAS NFKB1 8939996 398733 In addition , our results demonstrate that [CD95] mediated signaling *involves* activation of ( p50/RelA ) . Regulation FAS OPA1 22665482 2632833 In this study , we demonstrate that lysophosphatidic acid (LPA) , a growth factor-like present at high levels in ascites of ovarian cancer patients , *regulates* the sterol regulatory element binding [protein-FAS] and AMP activated protein kinase-ACC pathways in ovarian cancer cells but not in normal or immortalized ovarian epithelial cells . Regulation FAS PARP1 19228791 2054587 To investigate the *effect* of ( PARP-1 ) suppression on [CD95/Apo-1] ( Fas ) -induced apoptosis in fibroblast-like synoviocytes ( FLS ) from RA patients . Regulation FAS PIK3CA 16211288 1464582 Although inhibitors did not *affect* [Fas] expression in HL-60 cells , cellular FLICE-inhibitory protein ( c-FLIP ) levels were markedly reduced by PI 3-K inhibitor treatment . Regulation FAS PIK3CA 16527514 1589259 Although inhibitors did not *affect* the [Fas] expression of OSCC cells , cellular FLICE-inhibitory protein ( c-FLIP ) levels were markedly reduced by PI 3-K inhibitor treatment . Regulation FAS PIK3CA 22752304 2627251 We found that aerobic glycolysis and [FAS] occur in a *dependent* manner and appear to be interdependent . Regulation FAS PIK3R1 16211288 1464583 Although inhibitors did not *affect* [Fas] expression in HL-60 cells , cellular FLICE-inhibitory protein ( c-FLIP ) levels were markedly reduced by PI 3-K inhibitor treatment . Regulation FAS PIK3R1 16527514 1589260 Although inhibitors did not *affect* the [Fas] expression of OSCC cells , cellular FLICE-inhibitory protein ( c-FLIP ) levels were markedly reduced by PI 3-K inhibitor treatment . Regulation FAS PIK3R1 22752304 2627252 We found that aerobic glycolysis and [FAS] occur in a *dependent* manner and appear to be interdependent . Regulation FAS PLD1 10395739 627577 Therefore , these results suggest that Fas mediated phospholipase D activation may be a consequence of primary stimulation of phosphatidylcholine-specific phospholipase C and that may *play* a role in [Fas] cross linking signaling downstream from phosphatidylcholine-specific phospholipase C . Regulation FAS PLD2 10395739 627578 Therefore , these results suggest that Fas mediated activation may be a consequence of primary stimulation of phosphatidylcholine-specific phospholipase C and that phospholipase D may *play* a role in [Fas] cross linking signaling downstream from phosphatidylcholine-specific phospholipase C . Regulation FAS PLD3 10395739 627573 Therefore , these results suggest that Fas mediated activation may be a consequence of primary stimulation of phosphatidylcholine-specific phospholipase C and that phospholipase D may *play* a role in [Fas] cross linking signaling downstream from phosphatidylcholine-specific phospholipase C . Regulation FAS PLD4 10395739 627574 Therefore , these results suggest that Fas mediated activation may be a consequence of primary stimulation of phosphatidylcholine-specific phospholipase C and that phospholipase D may *play* a role in [Fas] cross linking signaling downstream from phosphatidylcholine-specific phospholipase C . Regulation FAS PLD5 10395739 627575 Therefore , these results suggest that Fas mediated phospholipase D activation may be a consequence of primary stimulation of phosphatidylcholine-specific phospholipase C and that may *play* a role in [Fas] cross linking signaling downstream from phosphatidylcholine-specific phospholipase C . Regulation FAS PLD6 10395739 627576 Therefore , these results suggest that Fas mediated activation may be a consequence of primary stimulation of phosphatidylcholine-specific phospholipase C and that phospholipase D may *play* a role in [Fas] cross linking signaling downstream from phosphatidylcholine-specific phospholipase C . Regulation FAS PPARG 15644454 1402290 Furthermore , the *regulated* induction of both SREBP-1 and [FAS] parallels an increase in de novo triacylglycerol synthesis in hepatocytes . Regulation FAS PPP3CA 10064053 593339 Regulation of cell surface expression of [Fas] ( CD95) ligand and susceptibility to Fas ( CD95 ) -mediated apoptosis in activation induced T cell death *involves* and protein kinase C , respectively . Regulation FAS PPP3CB 10064053 593340 Regulation of cell surface expression of [Fas] ( CD95) ligand and susceptibility to Fas ( CD95 ) -mediated apoptosis in activation induced T cell death *involves* and protein kinase C , respectively . Regulation FAS PPP3CC 10064053 593341 Regulation of cell surface expression of [Fas] ( CD95) ligand and susceptibility to Fas ( CD95 ) -mediated apoptosis in activation induced T cell death *involves* and protein kinase C , respectively . Regulation FAS PTK2 9558114 500052 These findings suggest that H2O2 induces up-regulation of [Fas] in ECs and that activation of may be *involved* in the mechanism of H2O2 induced Fas expression . Regulation FAS PTK6 9558114 500053 These findings suggest that H2O2 induces up-regulation of [Fas] in ECs and that activation of may be *involved* in the mechanism of H2O2 induced Fas expression . Regulation FAS PTK7 9558114 500054 These findings suggest that H2O2 induces up-regulation of [Fas] in ECs and that activation of may be *involved* in the mechanism of H2O2 induced Fas expression . Regulation FAS PXN 9658172 516986 An avian paxillin-CHO.K1 model system was used to explore the *role* of phosphorylation in paxillin localization to [FAs] . Regulation FAS RAC1 18676874 1967462 Our results demonstrate that OxPAPC induced *dependent* , Rho independent peripheral accumulation of paxillin containing [FAs] and time dependent paxillin phosphorylation . Regulation FAS RAC2 18676874 1967463 Our results demonstrate that OxPAPC induced *dependent* , Rho independent peripheral accumulation of paxillin containing [FAs] and time dependent paxillin phosphorylation . Regulation FAS RAC3 18676874 1967464 Our results demonstrate that OxPAPC induced *dependent* , Rho independent peripheral accumulation of paxillin containing [FAs] and time dependent paxillin phosphorylation . Regulation FAS RB1 15585647 1345672 [Fas] may therefore be a new therapeutic *target* for . Regulation FAS RELA 10072527 594498 Surprisingly , up-regulation of [Fas] , CD23 , and ICAM-1 was partially independent , and up-regulation of LFA-1 was completely *independent* , of CD40 induced activation . Regulation FAS RELA 10092091 600398 *regulates* [Fas/APO-1/CD95-] and TCR- mediated apoptosis of T lymphocytes . Regulation FAS RELA 10640741 660637 STAT-1alpha and activation are *involved* in IFN-gamma- or TNF-alpha mediated [Fas] up-regulation in microglia , respectively . Regulation FAS RELA 10671224 666703 T cell activation induced and HIV tat enhanced [CD95] ( APO-1/Fas ) ligand transcription *involves* . Regulation FAS RELA 15143063 1267525 *dependent* induction of tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) and [Fas/FasL] is crucial for efficient influenza virus propagation . Regulation FAS RELA 15601669 1375277 We studied the *role* of the transcription factor and of MAPKs in regulating [Fas] expression . Regulation FAS RELA 15619676 1357669 The *involvement* of in the regulation of [Fas] by RANKL was analyzed by luciferase assay and EMSA . Regulation FAS RELA 16103877 1489008 The *involvement* of and YY1 in the regulation of [Fas] expression was corroborated by the use of Ramos cells with a dominant-active inhibitor of NF-kappaB ( Ramos IkappaB-estrogen receptor (ER) mutant ) and by silencing YY1 with YY1 siRNA , respectively . Regulation FAS RELA 16317104 1526237 Epstein-Barr virus ( EBV ) induces CD95 expression and the [CD95] gene ( FAS ) is *regulated* by , STAT1 , and/or p53 . Regulation FAS RELA 16330535 1511997 [Fas] costimulation of naive CD4 T cells is *controlled* by signaling and caspase activity . Regulation FAS RELA 17291719 1725813 Caspase mediated activation of and ERKs were *involved* in [CD95L-] and TRAIL induced up-regulation of proinflammatory genes in Colo357-BclxL cells . Regulation FAS RELA 17786316 1790934 The inverse activities of [Fas] and FasL promoter in tumor cells are *regulated* by , which inhibits Fas expression and increases FasL expression through binding to their respective promoters . Regulation FAS RELA 8939996 398734 In addition , our results demonstrate that [CD95] mediated signaling *involves* activation of ( p50/RelA ) . Regulation FAS S100A6 10517668 652148 There was no consistent *effect* of induction on progestin mediated increases in [FAS] mRNA levels under these conditions . Regulation FAS SEC14L2 17589525 1768098 Splicing assays using the ULM-selective SPF45 variants demonstrate that individual UHM-ULM interactions are required for [FAS] splicing *regulation* by in vivo . Regulation FAS SERPINB9 16179941 1517503 The *role* of in [CD95] signaling : new insights into the mechanism of procaspase-8 activation . Regulation FAS SIK2 18239551 1877033 Electroporation was used to transiently transfect 3T3-L1 adipocytes with fatty acid synthase (FAS) promoter-driven luciferase construct to evaluate the *effect* of on [FAS] transcription . Regulation FAS SIRPA 15908323 1409447 Sirpalpha1P4Y2 downregulation of gankyrin expression was greater than that of Sirpalpha1 ( P < 0.05 ) , but no significant *effect* of and Sirpalpha1P4Y2 on CDK4 and [Fas] protein expression was observed in transfected Sk-hep1 lines ( P > 0.05 ) . Regulation FAS SIRPA 16698585 1560458 could significantly decrease the expression of cyclin D1 , beta-catenin and gankyrin , but it could n't *affect* the expression level of CDK4 and [Fas] . Regulation FAS SREBF1 10585876 571563 Reciprocally , co-transfection of Id3 antisense and ADD1 expression vectors in preadipocytes potentiated the *effect* on the [FAS] promoter activity . Regulation FAS SREBF1 11530940 853819 This finding was confirmed by using a dominant negative form of NF-YA , NF-YAm29 , which interferes with the *effect* of ectopically expressed on [FAS] reporter activity . Regulation FAS SREBF1 18079124 1868207 The mRNA expression of lipogenic genes Scd-1 and [Fas] is *regulated* partly by the insulin-sensitive transcription factor and liver X receptor alpha ( LXRalpha ) . Regulation FAS SREBF1 18420801 1899748 We also showed that [FAS] upregulation by HCV NS2 was *dependent* since deleting the SRE sequence in a FAS promoter and expressing a dominant negative SREBP-1 abrogated FAS promoter upregulation by HCV NS2 . Regulation FAS SREBF1 19252981 2157095 Transcription of the [FAS] gene is *controlled* synergistically by the transcription factors ChREBP ( carbohydrate response element binding protein ) , which is induced by glucose , and ( sterol response element binding protein-1 ) , which is stimulated by insulin through the PI3K/Akt signal transduction pathway . Regulation FAS STAT1 16317104 1526234 Epstein-Barr virus ( EBV ) induces CD95 expression and the [CD95] gene ( FAS ) is *regulated* by NF-kappaB , , and/or p53 . Regulation FAS STAT3 11733515 904577 *Regulation* of [Fas] expression by and c-Jun is mediated by phosphatidylinositol 3-kinase-AKT signaling . Regulation FAS STAT3 16651438 1558159 Consistent with the increased Fas/CD95 expression , a drastic decrease in the Tyr ( 705 ) phosphorylation of , a known negative *regulator* of [Fas/CD95] transcription , was found within 20 minutes in the luteolin treated cells , leading to down-regulation in the target gene products of STAT3 , such as cyclin D1 , survivin , Bcl-xL , and vascular endothelial growth factor . Regulation FAS STAT3 22313388 2565373 Consistent with the increased Fas/CD95 expression , a drastic decrease in the Tyr705 phosphorylation of , a known negative *regulator* of [Fas/CD95] transcription , was shown within 15 min in the EGCG treated cells , leading to downregulation of the target gene products of STAT3 , such as bcl-2 , vascular endothelial growth factor ( VEGF ) , mcl-1 , and cyclin D1 . Regulation FAS STRA13 15223310 1264787 Forced expression of STRA13 induced apoptosis , in agreement with the activation *effect* on the [Fas] promoter . Regulation FAS TAT 10671224 666706 The *effect* of on the human [CD95L] promoter activity was mapped to the same sites . Regulation FAS TAT 10671224 666707 Mutation of each NF-kappaB site also impaired the *effect* of on [CD95L] promotor activity . Regulation FAS TAT 9268734 450085 To test a possible activating effect of Tat on B cells , we examined the *effect* of purified on the expression of [Fas] , an activation marker , in B cells in primary culture . Regulation FAS TCF12 21794413 1847981 Since YY-1 down regulates Fas in cancer cell lines , it is reasonable to consider that this may *control* [Fas] expression in lupus nephritis . Regulation FAS TCF15 21794413 1847982 Since YY-1 down regulates Fas in cancer cell lines , it is reasonable to consider that this may *control* [Fas] expression in lupus nephritis . Regulation FAS TCF19 21794413 1847983 Since YY-1 down regulates Fas in cancer cell lines , it is reasonable to consider that this may *control* [Fas] expression in lupus nephritis . Regulation FAS TCF20 21794413 1847984 Since YY-1 down regulates Fas in cancer cell lines , it is reasonable to consider that this may *control* [Fas] expression in lupus nephritis . Regulation FAS TCF21 21794413 1847985 Since YY-1 down regulates Fas in cancer cell lines , it is reasonable to consider that this may *control* [Fas] expression in lupus nephritis . Regulation FAS TCF23 21794413 1847990 Since YY-1 down regulates Fas in cancer cell lines , it is reasonable to consider that this may *control* [Fas] expression in lupus nephritis . Regulation FAS TCF24 21794413 1847992 Since YY-1 down regulates Fas in cancer cell lines , it is reasonable to consider that this may *control* [Fas] expression in lupus nephritis . Regulation FAS TCF25 21794413 1847991 Since YY-1 down regulates Fas in cancer cell lines , it is reasonable to consider that this may *control* [Fas] expression in lupus nephritis . Regulation FAS TCF3 21794413 1847986 Since YY-1 down regulates Fas in cancer cell lines , it is reasonable to consider that this may *control* [Fas] expression in lupus nephritis . Regulation FAS TCF4 21794413 1847987 Since YY-1 down regulates Fas in cancer cell lines , it is reasonable to consider that this may *control* [Fas] expression in lupus nephritis . Regulation FAS TCF7 21794413 1847988 Since YY-1 down regulates Fas in cancer cell lines , it is reasonable to consider that this may *control* [Fas] expression in lupus nephritis . Regulation FAS TGFB1 11596030 870250 The *role* of ( TGF-beta1 ) in modulating the expression of [Fas] by CTLs is not known in HCC . Regulation FAS TGFB1 9543684 498237 Flow cytometric analyses showed that did not *affect* [Fas] expression on the cell surface . Regulation FAS TGFB1 9892606 586669 This decrease was associated with inhibition of Fas ( Apo-1/CD95) ligand (FasL ) expression , whereas [Fas] signaling was not *affected* by . Regulation FAS TMBIM1 21107705 2383504 Only high but not constitutive level of *controls* [Fas] signaling . Regulation FAS TNF 10457352 639311 Receptor studies showed that the *effect* of on [FAS] was mediated via the p55 TNF receptor . Regulation FAS TNF 7538820 306905 [Fas] antigen expression on lymphocytes is *regulated* by interferon gamma (IFN gamma) and , cytokines that also have inhibitory effects on hematopoiesis . Regulation FAS TNF 7542501 314119 IFN-gamma and had a synergistic *effect* on the induction of [Fas] , when both cytokines were added to the culture . Regulation FAS TNF 9255761 447745 HIV-1 infected myelomonocytic cells are resistant to Fas mediated apoptosis : *effect* of on their [Fas] expression and apoptosis . Regulation FAS TNFRSF1A 16267827 1483972 Lack of signaling also *affected* the expression of apoptosis/cell death related genes ( [Fas] , Rip , p53 ) , matrix metalloproteinases ( MMP3 , MMP9 , MMP12 ) , and their inhibitors ( TIMP1 ) , suggesting a role of TNFR1 in extracellular matrix remodeling after injury . Regulation FAS TNFRSF1B 9743381 532538 In this study , we show that this enhancement is TNFR60 selective , as neither TNF related apoptosis inducing ligand/Apo2 ligand- , [Apo1/Fas-] , ceramide- , nor daunorubicin mediated cell death was *affected* by costimulation of . Regulation FAS TNFSF10 18202809 1857500 The two cell lines did not respond to TNF-alpha ( 15 ng/ml ) , expressed a limited sensitivity to [anti-Fas] antibody ( 200 ng/ml ) and a different *response* to ( 100 ng/ml ) . Regulation FAS TNFSF11 15619676 1357665 *regulates* [Fas] expression and Fas mediated apoptosis in osteoclasts . Regulation FAS TNFSF11 15619676 1357666 Western blotting , semiquantitative RT-PCR , flow cytometry , nuclear staining , and a fluorescent caspase-3 activity assay were used to assess the *effect* of on [Fas] expression and Fas mediated apoptosis . Regulation FAS TNFSF11 15619676 1357667 The involvement of NF-kappaB in the *regulation* of [Fas] by was analyzed by luciferase assay and EMSA . Regulation FAS TNFSF11 15619676 1357670 The *regulation* of [Fas] expression by is biphasic . Regulation FAS TOP2A 17089011 1644225 Moreover , the up-regulatory *effects* of inhibitors on the transcriptional activation of [FAS] gene expression were not significantly decreased when the FAS promoter was damaged at the sterol regulatory element binding protein ( SREBP ) -binding site . Regulation FAS TP53 10660538 664480 We propose that *dependent* up-regulation of [Fas] does not induce apoptosis per se but sensitizes the cell to other pro-apoptotic signal ( s ) . Regulation FAS TP53 10951571 723696 *Involvement* of and interleukin 3 in the up-regulation of [CD95] ( APO-1/Fas ) by X-ray irradiation . Regulation FAS TP53 10969818 728478 We hypothesize that oncogenic activation and DNA damage are sufficient stimuli to increase the *dependent* transcription of [Fas] and thereby establish a situation in which cell to cell contact could be a selective pressure to either lose p53 function or inactivate components of the Fas death pathway . Regulation FAS TP53 11102960 756337 The *effects* of adenovirus mediated gene transfer ( Ad5CMV-p53 ) into human prostate cancer LNCaP , DU145 , and PC3 cells on their growth , apoptosis and [Fas] receptor/ligand expression were examined by the MTT assay , DNA fragmentation assay , and Northern blot analysis , respectively . Regulation FAS TP53 11103825 756380 These results implicate the *involvement* of wild-type in CD437 induced [Fas] expression in human NSCLC cells . Regulation FAS TP53 11793363 901979 However , the *role* of wild-type in [Fas] expression is still controversial . Regulation FAS TP53 11803462 903021 We show that , subsequent to sequestration and inactivation of the p53 tumour suppressor protein , SV40 abrogates *dependent* , DNA damage-inducible up-regulation of [CD95] surface expression . Regulation FAS TP53 11967210 933115 [Fas] is involved in the *dependent* apoptotic response to ionizing radiation in mouse testis . Regulation FAS TP53 14612511 1163335 *Role* of in regulating constitutive and X-radiation-inducible [CD95] expression and function in carcinoma cells . Regulation FAS TP53 14612511 1163337 However , whether *dependent* regulation of [CD95] expression is consistently associated with increased susceptibility to CD95 mediated cell death is poorly understood . Regulation FAS TP53 14719118 1197729 These results suggest that *regulates* [Fas/CD95] expression at the transcriptional level and through protein trafficking in mutant-p53 cell lines . Regulation FAS TP53 15661885 1365103 Our data indicate that BM depletion in acute GVHD is mediated by *dependent* up-regulation of [Fas] on BMC , which leads to Fas dependent depletion and subsequent disease . Regulation FAS TP53 16000635 1430745 [Fas] upregulation was *dependent* . Regulation FAS TP53 16317104 1526235 Epstein-Barr virus ( EBV ) induces CD95 expression and the [CD95] gene ( FAS ) is *regulated* by NF-kappaB , STAT1 , and/or . Regulation FAS TP53 16917513 1692170 However , we found that [Fas/CD95] was significantly induced in response to hypoxia in a *dependent* manner , along with several novel p53 target genes including ANXA1 , DDIT3/GADD153 ( CHOP ) , SEL1L and SMURF1 . Regulation FAS TP53 17505842 1766798 By Northern blot and Western blot analyses , we determined the *effect* of on the FasL and [Fas] receptor expression . Regulation FAS TP53 20597837 2309418 However , when we introduced p53 into H1299 cells , siDcr3 ( siRNA of Dcr3 ) suppressed the radioresistance of H1299 cells by inducing *dependent* [Fas] ( Fas receptor , also known as TNFRSF6 ; Regulation FAS TP53 21509038 2418641 More specifically , our results indicate that *dependent* induction of Fas membrane expression ( ~threefold ) and enhanced [Fas/FasL] interactions at the cell surface are important mechanisms of Nutlin-3 induced apoptosis in TC cells . Regulation FAS TP53 21709442 2460650 DR5 , [Fas] , Bax , Bad , Puma and Bnip3L were induced by 5-FU and adriamycin ( ADR ) in HCT116 cells in a *dependent* manner . Regulation FAS TP53 9841917 552943 In an attempt to understand how [CD95] expression is *regulated* by , we identified a p53-responsive element within the first intron of the CD95 gene , as well as three putative elements within the promoter . Regulation FAS USF1 7499393 333091 These data suggest that the regulation of expression may *play* an important role in the regulation of [FAS] transcription . Regulation FAS USF2 7499393 333092 These data suggest that the regulation of expression may *play* an important role in the regulation of [FAS] transcription . Regulation FAS YY1 16103877 1489006 The *involvement* of NF-kappaB and in the regulation of [Fas] expression was corroborated by the use of Ramos cells with a dominant-active inhibitor of NF-kappaB ( Ramos IkappaB-estrogen receptor (ER) mutant ) and by silencing YY1 with YY1 siRNA , respectively . Regulation FAS YY1 16143308 1454923 The direct *role* of in the negative regulation of [Fas] expression was demonstrated by transfection of cells with siRNA YY1 . Regulation FAS YY1 16784892 1599411 We have reported that [Fas] expression and sensitivity to FasL is negatively *regulated* by the transcription repressor factor . Regulation FAS YY1 21794413 1847989 Since down *regulates* [Fas] in cancer cell lines , it is reasonable to consider that this transcription factor may control Fas expression in lupus nephritis . Regulation FASLG ANGPT1 15763944 1352567 Interestingly , the DOX induced up-regulation in Fas ( CD95/APO-1 ) and Fas ligand expression could be blocked by Ang-1 , indicating a pivotal *role* of in DOX induced Fas and [Fas ligand] expression . Regulation FASLG EPHB2 19201817 2061387 Activation of GPR54 resulted in the *dependent* expression of tumor necrosis factor-alpha and [FasL] in a lymphoid cell line , the latter being the main trigger of apoptosis . Regulation FASLG EPHB2 20101459 2319499 The *effects* of cascade inhibitor and c-Myc inhibition by siRNA on 67-kDa laminin receptor induced [FasL] expression were determined . Regulation FASLG FAS 10556809 566005 Consistently , in Jurkat T cells , expression of PKCtheta AE / CaN significantly enhanced [FasL] protein expression and apoptosis in a *dependent* manner since cell death was not observed in T cells co-expressing the caspase-8 inhibitor crmA . Regulation FASLG FAS 11029528 739865 ii ) stromal mononuclear cells express [Fas ligand] in *response* to expression in carcinoma cells ; Regulation FASLG FAS 16226958 1469686 Coculture had synergistic effect on expression and no *effect* on [FasL] expression . Regulation FASLG FAS 21368861 2361304 In this study , we report that FasL processing by ADAM10 counteracts mediated cell death and is strictly *regulated* by membrane localization , interactions and modifications of [FasL] . Regulation FASLG FAS 9455798 484474 Melanoma cells expressed both Fas and [FasL] , but killing of melanoma cells did not *involve* interactions . Regulation FASLG IL1B 11777281 890671 Concentrations of IL-2 induced IL-10 and soluble [Fas ligand] ( sFasL ) were not *affected* by . Regulation FASLG MMP28 10533808 562479 We studied the inhibitory *effects* of various hydroxamate inhibitors on [FasL] and TNF-alpha processing in order to characterize the processing enzymes using human FasL cDNA transfectants and LPS stimulated THP-1 cells . Regulation FASLG MMP7 10533808 562494 We studied the inhibitory *effects* of various hydroxamate inhibitors on [FasL] and TNF-alpha processing in order to characterize the processing enzymes using human FasL cDNA transfectants and LPS stimulated THP-1 cells . Regulation FASLG TNF 10454352 637738 In the present study , we showed that [Fas-L] expression on AK-5 cells is *regulated* by interferon-gamma (IFN-gamma) and , as injection of antibodies against IFN-gamma downregulated the expression of Fas-L by tumor cells as determined by immunostaining and Northern hybridizations . Regulation FASLG TNF 11549697 856865 Thus , in the seminiferous tubules , germ cell derived may *regulate* the level of the [Fas ligand] and thereby control physiological germ cell apoptosis . Regulation FASLG TNF 9546786 498768 *regulation* of [Fas ligand] expression on the vascular endothelium modulates leukocyte extravasation . Regulation FASN FOXO1 24478438 2927952 Further investigation suggested that the expression of SREBP-1c and [FASN] is *controlled* by the transcription factor during HCV infection . Regulation FASN TNF 20606731 2286350 In vitro incubation of primary human hepatocytes with fatty acids dose-dependently induced cellular lipid-accumulation and FASN expression , while stimulation with did not *affect* [FASN] levels . Regulation FBN1 CTGF 21330667 2431528 The *effect* of on [fibrillin-1] expression in TM cells was investigated by real-time PCR . Regulation FBXO32 AKT1 16870627 1593139 Using dietary restriction , we find that it impedes sarcopenia as well as the effects of aging on phosphorylation , FOXO4 phosphorylation , and [Atrogin-1/MAFbx] and MuRF1 transcript *regulation* . Regulation FBXO32 AKT1 18346979 1919681 Constitutive activation of negatively *regulates* DOX mediated [atrogin-1] induction by inhibiting p38-MAPK activity as a novel mechanism . Regulation FBXO32 AKT2 16870627 1593140 Using dietary restriction , we find that it impedes sarcopenia as well as the effects of aging on phosphorylation , FOXO4 phosphorylation , and [Atrogin-1/MAFbx] and MuRF1 transcript *regulation* . Regulation FBXO32 AKT2 18346979 1919682 Constitutive activation of negatively *regulates* DOX mediated [atrogin-1] induction by inhibiting p38-MAPK activity as a novel mechanism . Regulation FBXO32 AKT3 16870627 1593141 Using dietary restriction , we find that it impedes sarcopenia as well as the effects of aging on phosphorylation , FOXO4 phosphorylation , and [Atrogin-1/MAFbx] and MuRF1 transcript *regulation* . Regulation FBXO32 AKT3 18346979 1919683 Constitutive activation of negatively *regulates* DOX mediated [atrogin-1] induction by inhibiting p38-MAPK activity as a novel mechanism . Regulation FBXO32 FOXO1 20079455 2218699 Results suggest that sepsis increases FOXO1 expression and activity in skeletal muscle by a glucocorticoid dependent mechanism and that glucocorticoid dependent upregulation of [atrogin-1] and MuRF1 in skeletal muscle is *regulated* by . Regulation FBXO32 FOXO3 19546233 2116777 In turn , the loss of IRS-1 activated the *dependent* induction of [atrogin-1/MAFbx] , a dominant mediator of proteolysis in atrophic muscle . Regulation FBXO32 FOXO4 16870627 1593142 Using dietary restriction , we find that it impedes sarcopenia as well as the effects of aging on AKT phosphorylation , phosphorylation , and [Atrogin-1/MAFbx] and MuRF1 transcript *regulation* . Regulation FBXO32 GHRL 18191156 1870214 In the present study , *effect* of ( GHRP-2 ) , a GH secretagogue receptor (GHS-R) agonist , on the expressions of [Atrogin-1] and MuRF1 in vivo rat muscles was examined . Regulation FBXO32 IGF1 15284206 1302578 To further delineate the *regulation* of [atrogin-1/MAFbx] by , we studied a model of cultured muscle cells . Regulation FBXO32 IGF1 20399749 2267370 In starved cells , MAFbx-alpha mRNA levels declined in response to amino acid , IGF-I and IGF-II treatments whereas [MAFbx-beta] levels only decreased in *response* to . Regulation FBXO32 INS 17418104 1728688 and amino acid availability *regulate* [atrogin-1] in avian QT6 cells . Regulation FBXO32 INS 17418104 1728690 In conclusion , expression of the ubiquitin ligase [atrogin-1] is *regulated* by both and amino acids through the TOR pathway . Regulation FBXO32 INS 24438646 2907313 Abundance of [atrogin-1] , but not MuRF1 , was greater in 26- than 6-d-old pigs and was not *affected* by , amino acids , or leucine . Regulation FBXO32 MAPK1 18346979 1919684 Constitutive activation of Akt negatively *regulates* DOX mediated [atrogin-1] induction by inhibiting activity as a novel mechanism . Regulation FBXO32 MAPK10 18346979 1919685 Constitutive activation of Akt negatively *regulates* DOX mediated [atrogin-1] induction by inhibiting activity as a novel mechanism . Regulation FBXO32 MAPK11 18346979 1919686 Constitutive activation of Akt negatively *regulates* DOX mediated [atrogin-1] induction by inhibiting activity as a novel mechanism . Regulation FBXO32 MAPK12 18346979 1919687 Constitutive activation of Akt negatively *regulates* DOX mediated [atrogin-1] induction by inhibiting activity as a novel mechanism . Regulation FBXO32 MAPK13 18346979 1919688 Constitutive activation of Akt negatively *regulates* DOX mediated [atrogin-1] induction by inhibiting activity as a novel mechanism . Regulation FBXO32 MAPK14 18346979 1919689 Constitutive activation of Akt negatively *regulates* DOX mediated [atrogin-1] induction by inhibiting activity as a novel mechanism . Regulation FBXO32 MAPK15 18346979 1919680 Constitutive activation of Akt negatively *regulates* DOX mediated [atrogin-1] induction by inhibiting activity as a novel mechanism . Regulation FBXO32 MAPK3 18346979 1919690 Constitutive activation of Akt negatively *regulates* DOX mediated [atrogin-1] induction by inhibiting activity as a novel mechanism . Regulation FBXO32 MAPK4 18346979 1919691 Constitutive activation of Akt negatively *regulates* DOX mediated [atrogin-1] induction by inhibiting activity as a novel mechanism . Regulation FBXO32 MAPK6 18346979 1919692 Constitutive activation of Akt negatively *regulates* DOX mediated [atrogin-1] induction by inhibiting activity as a novel mechanism . Regulation FBXO32 MAPK7 18346979 1919693 Constitutive activation of Akt negatively *regulates* DOX mediated [atrogin-1] induction by inhibiting activity as a novel mechanism . Regulation FBXO32 MAPK8 18346979 1919694 Constitutive activation of Akt negatively *regulates* DOX mediated [atrogin-1] induction by inhibiting activity as a novel mechanism . Regulation FBXO32 MAPK9 18346979 1919695 Constitutive activation of Akt negatively *regulates* DOX mediated [atrogin-1] induction by inhibiting activity as a novel mechanism . Regulation FBXO32 MPI 23437325 2744571 C2C12 myotubes and the KK-A ( y ) murine model of type 2 diabetes were used to evaluate the *effect* of on steady-state levels of ubiquitylation , proteasome activity and expression of [Atrogin-1] and MuRF-1 , muscle-specific ubiquitin ligases that are upregulated with impaired insulin signaling . Regulation FBXO32 MSTN 21964591 2497824 However , the exact signaling mechanisms by which *regulates* the expression of [Atrogin-1] and MuRF1 , as well as the proteins targeted for degradation in response to excess myostatin , remain to be elucidated . Regulation FBXO32 MSTN 23919379 2887765 Conclusively , the scFv we developed could antagonize the inhibitory *effects* of on myogenesis through Smad pathway and regulation of p21 , MuRF1 and [MAFbx] gene expression . Regulation FBXO32 POLDIP2 18346979 1919679 Constitutive activation of Akt negatively *regulates* DOX mediated [atrogin-1] induction by inhibiting activity as a novel mechanism . Regulation FBXO32 POLDIP2 23046544 2710506 Chromosome immunoprecipitation ( ChIP ) assay was used to evaluate and p38ß *effect* on C/EBPß binding to the [atrogin1/MAFbx] promoter . Regulation FBXO32 PRKAA1 17264220 1747272 Both [MAFbx] and MuRF1 mRNA increased dose dependently in *response* to these activators . Regulation FBXO32 PRKAA1 21921267 2497284 *regulates* the transcription of [Atrogin-1] and MuRF1 and enhances UPS mediated protein degradation in heart . Regulation FBXO32 PRKAA2 17264220 1747273 Both [MAFbx] and MuRF1 mRNA increased dose dependently in *response* to these activators . Regulation FBXO32 PRKAA2 21921267 2497285 *regulates* the transcription of [Atrogin-1] and MuRF1 and enhances UPS mediated protein degradation in heart . Regulation FBXO32 PRKAB1 17264220 1747274 Both [MAFbx] and MuRF1 mRNA increased dose dependently in *response* to these activators . Regulation FBXO32 PRKAB1 21921267 2497286 *regulates* the transcription of [Atrogin-1] and MuRF1 and enhances UPS mediated protein degradation in heart . Regulation FBXO32 PRKAB2 17264220 1747275 Both [MAFbx] and MuRF1 mRNA increased dose dependently in *response* to these activators . Regulation FBXO32 PRKAB2 21921267 2497287 *regulates* the transcription of [Atrogin-1] and MuRF1 and enhances UPS mediated protein degradation in heart . Regulation FBXO32 PRKAG1 17264220 1747276 Both [MAFbx] and MuRF1 mRNA increased dose dependently in *response* to these activators . Regulation FBXO32 PRKAG1 21921267 2497288 *regulates* the transcription of [Atrogin-1] and MuRF1 and enhances UPS mediated protein degradation in heart . Regulation FBXO32 PRKAG2 17264220 1747277 Both [MAFbx] and MuRF1 mRNA increased dose dependently in *response* to these activators . Regulation FBXO32 PRKAG2 21921267 2497289 *regulates* the transcription of [Atrogin-1] and MuRF1 and enhances UPS mediated protein degradation in heart . Regulation FBXO32 PTGS2 23388481 2713084 *Effect* of inhibition by meloxicam , on [atrogin-1] and myogenic regulatory factors in skeletal muscle of rats injected with endotoxin . Regulation FBXO32 SERPINB5 21725612 2471462 The *effects* of on KHDRBS3 and [FBXO32] expression in GC cells were analyzed using real-time PCR and Western blotting after the expression of SerpinB5 was modified . Regulation FBXO32 TCF12 16507768 1529564 The transcriptional regulation of human [atrogin-1] may be *controlled* by an Akt mediated other than FKHR or via another signaling pathway . Regulation FBXO32 TCF15 16507768 1529565 The transcriptional regulation of human [atrogin-1] may be *controlled* by an Akt mediated other than FKHR or via another signaling pathway . Regulation FBXO32 TCF19 16507768 1529566 The transcriptional regulation of human [atrogin-1] may be *controlled* by an Akt mediated other than FKHR or via another signaling pathway . Regulation FBXO32 TCF20 16507768 1529567 The transcriptional regulation of human [atrogin-1] may be *controlled* by an Akt mediated other than FKHR or via another signaling pathway . Regulation FBXO32 TCF21 16507768 1529568 The transcriptional regulation of human [atrogin-1] may be *controlled* by an Akt mediated other than FKHR or via another signaling pathway . Regulation FBXO32 TCF23 16507768 1529572 The transcriptional regulation of human [atrogin-1] may be *controlled* by an Akt mediated other than FKHR or via another signaling pathway . Regulation FBXO32 TCF24 16507768 1529574 The transcriptional regulation of human [atrogin-1] may be *controlled* by an Akt mediated other than FKHR or via another signaling pathway . Regulation FBXO32 TCF25 16507768 1529573 The transcriptional regulation of human [atrogin-1] may be *controlled* by an Akt mediated other than FKHR or via another signaling pathway . Regulation FBXO32 TCF3 16507768 1529569 The transcriptional regulation of human [atrogin-1] may be *controlled* by an Akt mediated other than FKHR or via another signaling pathway . Regulation FBXO32 TCF4 16507768 1529570 The transcriptional regulation of human [atrogin-1] may be *controlled* by an Akt mediated other than FKHR or via another signaling pathway . Regulation FBXO32 TCF7 16507768 1529571 The transcriptional regulation of human [atrogin-1] may be *controlled* by an Akt mediated other than FKHR or via another signaling pathway . Regulation FBXW5 IL1B 19232515 2050511 [FBXW5] associated with endogenous TAK1 in an *dependent* manner . Regulation FCER2 TLR7 19635918 2118572 To begin to understand physiologic determinants of CD23 expression , we analyzed *effects* of BCR and stimulation on [CD23] levels . Regulation FCER2 TNF 7547698 327055 *regulates* IL-4 induced [Fc epsilon RII/CD23] gene expression and soluble Fc epsilon RII release by human monocytes . Regulation FCER2 TNF 7547698 327057 We examined the regulatory *effects* of on IL-4 induced gene expression of the low-affinity receptor for IgE ( Fc epsilon RII/CD23 ) in human monocytes and IL-4 induced soluble [Fc epsilon RII] ( sFc epsilon RII ) release from monocytes . Regulation FCER2 TNF 7547698 327061 [Fc epsilon RII] mRNA expression in monocytes cultured with IL-4 was not *affected* by when examined at 6 h after cultivation . Regulation FCER2 TNF 9122614 423987 *regulates* GM-CSF- , IL-3- or M-CSF induced [Fc epsilon RII/CD23] gene expression and soluble Fc epsilon RII release by human monocytes . Regulation FCER2 TNF 9122614 423998 These results suggest that *dependent* reduction of GM-CSF- , IL-3- or M-CSF induced [Fc epsilon RII] expression on the surface of monocytes resulted , at least in part , from the suppression of Fc epsilon RII mRNA and the enhancement of sFc epsilon RII release . Regulation FCER2 TNF 9298175 453281 N-acetylcysteine attenuates *dependent* reduction of IL-4 induced [Fc epsilon RII] expression in human monocytes . Regulation FCER2 TNF 9298175 453286 Therefore , we hypothesized that *dependent* reduction of IL-4 induced [Fc epsilon RII] expression in monocytes might be mediated through the ROIs activated mechanism . Regulation FCER2 TNF 9298175 453289 In the present study , to test our hypothesis , we examined the effect of NAC on *dependent* reduction of IL-4 induced [Fc epsilon RII] expression in human monocytes . Regulation FCER2 TNF 9298175 453294 NAC attenuated *dependent* reduction of IL-4 induced [Fc epsilon RII] expression by attenuating TNF-alpha dependent reduction of Fc epsilon RII mRNA expression . Regulation FCER2 TNF 9298175 453297 These results indicate that an ROIs activated and antioxidant-sensitive mechanism might be involved in *dependent* reduction of IL-4 induced [Fc epsilon RII] expression in monocytes . Regulation FCGR1A TNF 8296157 248380 , as well as interferon-gamma (IFN-gamma) or interleukin-6 (IL-6) had a significant up-regulating *effect* on U937 expression of [Fc gamma RI/CD64] . Regulation FCGR2A EPHB2 17312151 1699696 WT [FcgammaRIIA] and mutants that associated with lipid rafts efficiently activated NF-kappaB , in an *dependent* manner . Regulation FCGR3B ITGB2 9824771 549172 CD10 , CD11b , CD11c , CD13 , , CD35 , CD45 , CD66acde , and CD66b were upregulated at 15 min and remained upregulated at 180 min . CD61 and CD63 increased slightly at 15 min and returned to baseline by 180 min . [CD16] and CD62L were down *regulated* at 15 min and normalized by 180 min. CD15s , CDw17 , CD32 , and CD44 were slightly down regulated at 15 min and then returned to baseline by 180 min . CD11a , CD15 , CD24 , CD31 , and CDw65 did not change during dialysis . Regulation FCGR3B TNF 20102624 2258733 The *effects* of , OC-promoting ( M-CSF plus RANKL ) , and dendritic cell ( DC ) -promoting ( GM-CSF plus interleukin (IL)-4 ) cytokines on [CD16] surface expression were examined by flow cytometry . Regulation FDFT1 TNF 11111077 757490 [SQS] activity , protein , and mRNA levels are *regulated* by cholesterol status and by the cytokines and IL-1beta . Regulation FGB F2R 19422454 2101109 We found that FXIII-A represents the only detectable source of TG activity in platelets and that the binding of [fibrinogen] in *response* to stimulation was significantly reduced in platelets from the patients . Regulation FGB FAS 11136460 769803 A novel growth phase associated two-component-type regulator , ( [fibronectin/fibrinogen] binding/haemolytic activity/streptokinase *regulator* ) , of Streptococcus pyogenes was identified in the M1 genome sequence , based on homologies to the histidine protein kinase ( HPK ) and response regulator ( RR ) part of the Staphylococcus aureus Agr and Streptococcus pneumoniae Com quorum sensing systems . Regulation FGB IL1B 12202007 983014 however , NO did not mediate the *effect* of on albumin and [fibrinogen] production , and played a minor role in IL-1beta mediated urea synthesis suppression . Regulation FGB IL1B 9359864 462284 In contrast , this pathway does not appear to participate in mediating the inhibitory *effects* of on [fibrinogen] induction by IL-6 . Regulation FGB IL6R 8427597 212426 Ciliary neurotrophic factor *regulates* [fibrinogen] gene expression in hepatocytes by binding to the . Regulation FGB ITGB2 18316072 1886051 Adsorbed [fibrinogen] regulates the behavior of human dendritic cells in a *dependent* manner . Regulation FGB ITGB2 18541300 1934676 Integrin mediated adhesion of human monocytes to [fibrinogen] *regulated* by and the closely related integrin CD11c/CD18 , play a key role in inflammation . Regulation FGB ITGB2 21874872 2473882 The *role* of beta2-integrins and CD 11c/CD 18 in adhesion and migration of leukocytes on [fibrinogen] was studied . Regulation FGB TGM2 2902077 97023 Thus , [fibrinogen] and fibronectin binding to hepatocytes is *independent* of activity , whereas cross linking of these adhesive macromolecules requires an enzymatically active cellular transglutaminase . Regulation FGB TGM2 6111391 14685 The enzyme is *involved* in the binding of the [fibrinogen] or fibrin to the cell surface . Regulation FGB TNF 2201637 140476 Tumor necrosis factor (TNF) is induced in mice by Candida albicans : *role* of in [fibrinogen] increase . Regulation FGB TNF 8867673 344811 In the absence of divalent cations or in the presence of Ca2+ alone , PMN did not adhere to [fibrinogen] in *response* to . Regulation FGF1 FGFBP1 15806171 1439296 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Regulation FGF1 IL1B 11040101 741898 In this study , we examined the *effects* of on the expression of vascular [endothelial cell growth factor] ( VEGF ) and pursued the molecular mechanisms underlying this effect . Regulation FGF1 IL1B 12044971 949920 *Effects* of IL6 and on [aFGF] expression and excitotoxicity in NT2N cells . Regulation FGF1 IL1B 7533232 286229 In situ hybridization was used to study the *effect* of on [acidic fibroblast growth factor (aFGF)] and basic fibroblast growth factor (bFGF) mRNA expression in rat brain . Regulation FGF10 FGFBP1 15806171 1439299 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Regulation FGF11 FGFBP1 15806171 1439302 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Regulation FGF12 FGFBP1 15806171 1439305 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Regulation FGF13 FGFBP1 15806171 1439308 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Regulation FGF14 FGFBP1 15806171 1439311 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Regulation FGF16 FGFBP1 15806171 1439314 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Regulation FGF17 FGFBP1 15806171 1439317 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Regulation FGF18 FGFBP1 15806171 1439320 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Regulation FGF19 FGFBP1 15806171 1439323 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Regulation FGF2 EDN2 23469133 2750251 Our findings indicate that the increased expression of PR Edn2 increases PR survival , and suggest that the *dependent* increase in PR expression of [FGF2] may contribute to the augmented survival . Regulation FGF2 EPHB2 15247255 1295846 [Fibroblast growth factor-2] induction of platelet derived growth factor-C chain transcription in vascular smooth muscle cells is *dependent* but not JNK dependent and mediated by Egr-1 . Regulation FGF2 EPHB2 15247255 1295856 Moreover , using pharmacological inhibitors we demonstrate the critical *role* of but not JNK in [FGF-2-inducible] PDGF-C expression . Regulation FGF2 EPHB2 18656513 1972813 Relative *role* of upstream regulators of Akt , and CREB in NCAM- and [FGF2] mediated signalling . Regulation FGF2 FGFBP1 15806171 1439326 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Regulation FGF2 HBEGF 12882762 1150062 *regulates* elastin and [FGF-2] expression in pulmonary fibroblasts . Regulation FGF2 HBEGF 8756003 374677 The *effect* of on [FGF-2] mRNA levels appears to be mediated primarily by a transcriptional mechanism and requires de novo synthesized proteins . Regulation FGF2 IL1B 7533232 286230 In situ hybridization was used to study the *effect* of on acidic fibroblast growth factor (aFGF) and [basic fibroblast growth factor (bFGF)] mRNA expression in rat brain . Regulation FGF2 MAP2K6 10511312 651254 In contrast , [FGF-2] regulation of p21 is largely *independent* of and Ras . Regulation FGF2 RNASE1 8919029 396388 Neither nor puromycin treatment *affected* the in vivo binding of [FGF-2] to ribosomes suggesting that FGF-2 binds ribosomal protein or rRNA , but not mRNA . Regulation FGF2 RNASE7 8919029 396396 Neither nor puromycin treatment *affected* the in vivo binding of [FGF-2] to ribosomes suggesting that FGF-2 binds ribosomal protein or rRNA , but not mRNA . Regulation FGF2 TNF 10595927 573191 Neither nor interferon-gamma *affected* [bFGF] synthesis by HPMCs . Regulation FGF2 TNF 14962263 1208673 Current data suggest that the action of thalidomide is related to several different mechanisms , including suppression of , *effects* on [basic fibroblast growth factor] , vascular endothelial growth factor , interleukins and interferons , downregulation of selected cell surface adhesion molecules , and changes in the lymphocyte subsets . Regulation FGF2 TNF 22492039 2583489 Furthermore , astrocytes in culture express high levels of [FGF-2] in response to IL-1ß , and IGF-1 in *response* to stimulation . Regulation FGF2 TNF 9430495 482116 Immunostaining , RT-PCR , ELISA , immunoblot and Northern blot analyses were employed to study four murine MC lines for [FGF-2] expression and its *regulation* by transforming growth factor-beta ( TGF-beta ) , stem cell factor (SCF) , and . Regulation FGF20 FGFBP1 15806171 1439329 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Regulation FGF21 FGFBP1 15806171 1439332 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Regulation FGF22 FGFBP1 15806171 1439335 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Regulation FGF23 FGFBP1 15806171 1439338 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Regulation FGF3 FGFBP1 15806171 1439341 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Regulation FGF3 MSX1 9753686 535105 Moreover , dental epithelium as well as beads soaked in FGF1 , FGF2 or FGF8 induce [Fgf3] expression in dental mesenchyme in an *dependent* manner . Regulation FGF4 FGFBP1 15806171 1439344 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Regulation FGF5 FGFBP1 15806171 1439347 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Regulation FGF6 FGFBP1 15806171 1439350 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Regulation FGF7 CD14 12438323 1016555 Induction of [keratinocyte growth factor] 1 Expression by lipopolysaccharide is *regulated* by and toll-like receptors 2 and 4 . Regulation FGF7 FGFBP1 15806171 1439353 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Regulation FGF7 IL1B 9220246 442532 To determine whether interleukin 1 beta (IL-1 beta) messenger RNA ( mRNA ) and protein were expressed in corneal cells and to examine the *effects* of IL-1 alpha and on the expression of hepatocyte growth factor (HGF) and [keratinocyte growth factor (KGF)] mRNAs and proteins in corneal stromal fibroblasts . Regulation FGF7 KRT38 7537080 300412 [Keratinocyte growth factor] and gene *regulation* . Regulation FGF8 FGFBP1 15806171 1439356 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Regulation FGF9 FGFBP1 15806171 1439359 The is a novel interaction partner of FGF-7 , FGF-10 and FGF-22 and *regulates* [FGF] activity : implications for epithelial repair . Regulation FGFBP1 CEBPB 12670924 1076219 Complex *regulation* of the [fibroblast growth factor binding protein] in MDA- MB-468 breast cancer cells by . Regulation FGFBP1 EGF 10753873 682061 In this study , we examine the *regulation* of [FGF-BP] by and the signal transduction mechanisms that mediate this effect . Regulation FGFR2 TP63 12692135 1100007 We thus propose that a complex differentially *regulates* [FGFR-2] expression by supporting alternative splicing of the K-SAM isoform of FGFR-2 . Regulation FGFR3 GLP1R 22075777 2540663 ELISA was used to study *effects* on neural release of [acetylcholine (ACh)] . Regulation FGFR3 LYNX1 17286989 1747338 These results suggest that both SLURP-1 and are expressed in various immune cells and organs , and that not only [ACh] but also SLURPs may be *involved* in regulating lymphocyte function via nAChR mediated pathways . Regulation FGFR4 FOXO1 20663909 2305263 We also provide the first direct evidence that [FGFR4] and IGF1R are the *targets* for . Regulation FGL2 TNF 23432784 2822971 This study investigates whether *regulates* [fibrinogen-like protein 2 (fgl2)] expression , a procoagulant resulting in the formation of fibrin-rich microthrombus in MI/R injury . Regulation FHIT MAP2K6 23618899 2795409 and ( iii ) to determine the *role* of DNMT and inhibitors on expressions of WWOX and [FHIT] in response to arsenite in SV-HUC-1 . Regulation FHL1 FAR1 18670649 1943278 The transcription of FHY1 and [FHL] are *controlled* by FHY3 ( Far red elongated HYpocotyl 3 ) and ( FAr red impaired Response 1 ) , a related pair of transcription factors , which thus indirectly control phyA nuclear accumulation . Regulation FHL1 HOXD13 18758158 1956611 This study aimed to verify whether directly *regulates* [skeletal muscle LIM protein 1] ( Fhl1 ) expression during limb development in rat embryo , which will serve as a basis for comprehending etiological research of idiopathic CCF . Regulation FHL1 HOXD13 18758158 1956614 Thus , directly *regulates* [Fhl1] expression in rat embryo . Regulation FHL1 HOXD13 18758158 1956616 These findings suggest that may *regulate* the expression of [FHL1] in the development of idiopathic CCF . Regulation FHL1 MYLIP 18801012 2021103 We also demonstrate that induction of is *controlled* by [SLIM1] , a key transcription factor in the sulphur assimilation pathway . Regulation FHL1 TCF12 18725486 1961799 Furthermore , we demonstrated that regulation of [Fhl-1] was hypoxia-inducible *dependent* . Regulation FHL1 TCF15 18725486 1961800 Furthermore , we demonstrated that regulation of [Fhl-1] was hypoxia-inducible *dependent* . Regulation FHL1 TCF19 18725486 1961801 Furthermore , we demonstrated that regulation of [Fhl-1] was hypoxia-inducible *dependent* . Regulation FHL1 TCF20 18725486 1961802 Furthermore , we demonstrated that regulation of [Fhl-1] was hypoxia-inducible *dependent* . Regulation FHL1 TCF21 18725486 1961803 Furthermore , we demonstrated that regulation of [Fhl-1] was hypoxia-inducible *dependent* . Regulation FHL1 TCF23 18725486 1961807 Furthermore , we demonstrated that regulation of [Fhl-1] was hypoxia-inducible *dependent* . Regulation FHL1 TCF24 18725486 1961809 Furthermore , we demonstrated that regulation of [Fhl-1] was hypoxia-inducible *dependent* . Regulation FHL1 TCF25 18725486 1961808 Furthermore , we demonstrated that regulation of [Fhl-1] was hypoxia-inducible *dependent* . Regulation FHL1 TCF3 18725486 1961804 Furthermore , we demonstrated that regulation of [Fhl-1] was hypoxia-inducible *dependent* . Regulation FHL1 TCF4 18725486 1961805 Furthermore , we demonstrated that regulation of [Fhl-1] was hypoxia-inducible *dependent* . Regulation FHL1 TCF7 18725486 1961806 Furthermore , we demonstrated that regulation of [Fhl-1] was hypoxia-inducible *dependent* . Regulation FHL1 TLX1 18073142 1861921 Transcriptional *regulation* of [FHL1] by is dosage , cell-type and promoter context dependent . Regulation FHL1 UNC13D 24043286 2846303 Intriguingly , the patient carried mutations in FAS , XIAP , and genes , which are *involved* in ALPS , XLP disease , and [FHL] , respectively . Regulation FIGF IL1B 17929249 1866352 RT-PCR and Western blot analyses confirmed decreased expression of [VEGF-D] in *response* to . Regulation FIGF IL1B 17929249 1866359 This is the first report to indicate inhibition of [VEGF-D] gene expression in *response* to in cardiac microvascular endothelial cells , a cell type of central interest in angiogenesis . Regulation FLG BMP1 21079999 2354846 We present evidence that signaling *regulates* [filaggrin] expression in the epidermis . Regulation FLG BMP1 21079999 2354855 *Regulation* of [filaggrin] expression by signaling has been further confirmed by the application of exogenous BMP2 in skin explants and by a transgenic model overexpressing Noggin in the epidermis . Regulation FLG BMP10 21079999 2354854 We present evidence that signaling *regulates* [filaggrin] expression in the epidermis . Regulation FLG BMP10 21079999 2354863 *Regulation* of [filaggrin] expression by signaling has been further confirmed by the application of exogenous BMP2 in skin explants and by a transgenic model overexpressing Noggin in the epidermis . Regulation FLG BMP15 21079999 2354847 We present evidence that signaling *regulates* [filaggrin] expression in the epidermis . Regulation FLG BMP15 21079999 2354856 *Regulation* of [filaggrin] expression by signaling has been further confirmed by the application of exogenous BMP2 in skin explants and by a transgenic model overexpressing Noggin in the epidermis . Regulation FLG BMP2 21079999 2354848 We present evidence that signaling *regulates* [filaggrin] expression in the epidermis . Regulation FLG BMP2 21079999 2354857 *Regulation* of [filaggrin] expression by signaling has been further confirmed by the application of exogenous BMP2 in skin explants and by a transgenic model overexpressing Noggin in the epidermis . Regulation FLG BMP3 21079999 2354849 We present evidence that signaling *regulates* [filaggrin] expression in the epidermis . Regulation FLG BMP3 21079999 2354858 *Regulation* of [filaggrin] expression by signaling has been further confirmed by the application of exogenous BMP2 in skin explants and by a transgenic model overexpressing Noggin in the epidermis . Regulation FLG BMP4 21079999 2354850 We present evidence that signaling *regulates* [filaggrin] expression in the epidermis . Regulation FLG BMP4 21079999 2354859 *Regulation* of [filaggrin] expression by signaling has been further confirmed by the application of exogenous BMP2 in skin explants and by a transgenic model overexpressing Noggin in the epidermis . Regulation FLG BMP5 21079999 2354851 We present evidence that signaling *regulates* [filaggrin] expression in the epidermis . Regulation FLG BMP5 21079999 2354860 *Regulation* of [filaggrin] expression by signaling has been further confirmed by the application of exogenous BMP2 in skin explants and by a transgenic model overexpressing Noggin in the epidermis . Regulation FLG BMP6 21079999 2354852 We present evidence that signaling *regulates* [filaggrin] expression in the epidermis . Regulation FLG BMP6 21079999 2354861 *Regulation* of [filaggrin] expression by signaling has been further confirmed by the application of exogenous BMP2 in skin explants and by a transgenic model overexpressing Noggin in the epidermis . Regulation FLG BMP7 21079999 2354853 We present evidence that signaling *regulates* [filaggrin] expression in the epidermis . Regulation FLG BMP7 21079999 2354862 *Regulation* of [filaggrin] expression by signaling has been further confirmed by the application of exogenous BMP2 in skin explants and by a transgenic model overexpressing Noggin in the epidermis . Regulation FLG C19orf10 20861853 2363889 As null mutations of filaggrin are associated with the development of an impaired skin barrier in AD , we investigated whether *affects* [filaggrin] synthesis by keratinocytes . Regulation FLG CA2 11286634 799876 Cell counting , 5-bromo-2'-deoxyuridine incorporation , and western blot analysis showed that fibroblast growth factor 10 , similarly to keratinocyte growth factor , not only is a potent mitogen for human keratinocytes , but also promotes the expression of both early differentiation markers K1 and K10 and late differentiation marker [filaggrin] in *response* to the signal , and seems to sustain the proliferative activity in suprabasal stratified cells . Regulation FLG CAPN1 19286660 2063845 Collectively , our results suggest that BH is essential for the synthesis of natural moisturizing factors and that would *play* a role as an upstream protease in the degradation of [filaggrin] . Regulation FLG CAPNS1 19286660 2063846 Collectively , our results suggest that BH is essential for the synthesis of natural moisturizing factors and that would *play* a role as an upstream protease in the degradation of [filaggrin] . Regulation FLG CASP14 21183321 2378828 Activation of occurs during terminal differentiation of keratinocytes and may *play* a role in [filaggrin] degradation . Regulation FLG CASP14 21997417 2493682 Acting in concert with other proteases , *controls* the breakdown of [filaggrin] to free amino acids and amino acid derivatives that contribute to the hydration and UVB absorption capacity of the stratum corneum . Regulation FLG HRAS 17045653 1666552 In the present study , we investigated the *role* of in [FLG-] and LPS mediated signaling in ERK activation in chicken heterophils . Regulation FLG IL22 21564072 2470224 To investigate the *effects* of on expression of [filaggrin] and genes encoding proteins relevant to epidermal function . Regulation FLG IL31 22177328 2543132 *regulates* differentiation and [filaggrin] expression in human organotypic skin models . Regulation FLG KRAS 17045653 1666553 In the present study , we investigated the *role* of in [FLG-] and LPS mediated signaling in ERK activation in chicken heterophils . Regulation FLG NRAS 17045653 1666554 In the present study , we investigated the *role* of in [FLG-] and LPS mediated signaling in ERK activation in chicken heterophils . Regulation FLG PTGER2 20230798 2244148 The effects of the prostanoid EP receptor agonists , limaprost , butaprost , and sulprostone on filaggrin gene expression in NHK suggest that the *plays* a significant role in the PGE ( 2 ) -mediated [filaggrin] down-regulation . Regulation FLI1 FOXO1 23995784 2948771 In addition to regulation by direct promoter binding of EWS-FLI1 , its subcellular localization and activity is *regulated* by cyclin dependent kinase 2- and AKT mediated phosphorylation downstream of [EWS-FLI1] . Regulation FLNA CAPN8 24550283 2915442 Hypoxia induces a *dependent* cleavage of [FLNA] to generate a naturally occurring C-terminal fragment that accumulates in the cell nucleus . Regulation FLT1 EPHB2 20141840 2208143 Mechanistically , K5-SOS upregulates VEGF , [Flt1] , and Neuropilin-1 in an *dependent* manner , thereby activating an autocrine proliferation loop , whereas EGFR prevents tumor cells from apoptosis . Regulation FLT1 IL1B 17071533 1637657 *regulates* vascular endothelial growth factor and soluble [fms-like tyrosine kinase-1] secretion by human oviductal epithelial cells and stromal fibroblasts . Regulation FN1 AGR2 25092909 2956952 Therefore , while *regulates* [fibronectin] binding in SCVs , it can not promote hemolysin production in the absence of a functional electron transport chain . Regulation FN1 CTGF 11934704 927855 *Role* of in [fibronectin] expression and tubulointerstitial fibrosis . Regulation FN1 CTGF 11934704 927856 Thus *plays* a crucial role in [fibronectin] synthesis induced by TGF-beta , suggesting that CTGF blockade could be a possible therapeutic target against tubulointerstitial fibrosis . Regulation FN1 CTGF 16527597 1536197 *Role* of in [fibronectin] synthesis in cultured human prostate stromal cells . Regulation FN1 CTGF 17399955 1748566 The up-regulation of angiotensin II receptor type 1 and are *involved* in high-glucose induced [fibronectin] production by cultured human dermal fibroblasts . Regulation FN1 EPHB2 11251083 793887 In addition , we demonstrated that inhibition of extracellular matrix receptor , such as integrin beta1 subunit , leads to cell arrest in G1 , whereas EGF was found to up-regulated integrin beta1 and [fibronectin] in a *dependent* manner . Regulation FN1 EPHB2 16960555 1682627 These results reveal a tumor-specific *regulation* of [fibronectin] by constitutive kinase signaling and indicate that self production of fibronectin may play a role in melanoma tumorigenesis , by promoting tumor cell invasion . Regulation FN1 FAS 11136460 769804 A novel growth phase associated two-component-type regulator , ( [fibronectin/fibrinogen] binding/haemolytic activity/streptokinase *regulator* ) , of Streptococcus pyogenes was identified in the M1 genome sequence , based on homologies to the histidine protein kinase ( HPK ) and response regulator ( RR ) part of the Staphylococcus aureus Agr and Streptococcus pneumoniae Com quorum sensing systems . Regulation FN1 IL1B 12081561 958401 In contrast , a pan-specific TGF-beta neutralizing antibody significantly blocked the *effects* of on PTC [fibronectin] secretion ( IL-1beta , 268.1 +/- 30.6 vs. IL-1beta+alphaTGF-beta 157.9 +/- 14.4 % , of control values , P < 0.001 ) and DNA synthesis ( IL-1beta 81.0 +/- 6.7 % vs. IL-1beta+alphaTGF-beta 93.4 +/- 2.1 % , of control values , P < 0.01 ) . Regulation FN1 IL1B 1304431 208935 The in vivo systemic *effect* of human recombinant on [fibronectin] in rats . Regulation FN1 IL1B 7896895 299977 Thus , our studies suggest that vascular SMC [fibronectin] synthesis is *regulated* by reciprocal induction of and TNF-alpha activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Regulation FN1 IL1B 8205691 261187 We previously identified in piglet cardiac allografts an immunoinflammatory response in coronary arteries in which increased [fibronectin] *regulated* by was associated with early evidence of intimal thickening . Regulation FN1 MAP2K6 11251083 793893 In addition , we demonstrated that inhibition of extracellular matrix receptor , such as integrin beta1 subunit , leads to cell arrest in G1 , whereas EGF was found to up-regulated integrin beta1 and [fibronectin] in a *dependent* manner . Regulation FN1 MMP7 17554258 1778563 Our findings suggest that diminished expression of the glycoprotein degrading enzyme , , may *play* a role in [fibronectin] accumulation in the diabetic kidney in response to AGEs and/or TGF-beta . Regulation FN1 S1PR3 22406263 2577329 In the current study , we explored *role* of in [fibronectin] expression and underlying molecular mechanism . Regulation FN1 TGM2 2902077 97030 Thus , fibrinogen and [fibronectin] binding to hepatocytes is *independent* of activity , whereas cross linking of these adhesive macromolecules requires an enzymatically active cellular transglutaminase . Regulation FN1 TNF 10333360 615054 The aim of this study was to determine the *effects* of , interleukin-1 alpha (IL-1alpha) , macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases (MMP) , human chorionic gonadotrophin (HCG) and fetal [fibronectin] ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro . Regulation FN1 TNF 10893215 711347 Transglutaminase mediated [fibronectin] multimerization in lung endothelial matrix in *response* to . Regulation FN1 TNF 11440974 833346 Northern blotting showed no *effect* of on steady-state [fibronectin] mRNA levels . Regulation FN1 TNF 2495726 109568 The *effects* of interferon-gamma and on [fibronectin] production by epidermal melanocytes are in contrast to the effects of the same treatments on fibronectin production by epidermal keratinocytes where fibronectin production is decreased but are similar to the effects of transforming growth factor-beta on a number of other cell types in which increased synthesis of fibronectin occurs and is associated with decreased growth . Regulation FN1 TNF 2541208 110482 Differential *regulation* of collagen , glycosaminoglycan , [fibronectin] , and collagenase activity production in cultured human adult dermal fibroblasts by interleukin 1-alpha and beta and and beta . Regulation FN1 TNF 2541208 110484 In order to clarify the role played by immunologically derived cytokines in dermal connective tissue synthesis and degradation , we investigated the *effect* of human recombinant (hu-r) interleukin (IL) 1-alpha and beta , hu-r and beta , hu-r IL 2 , and hu-r granulocyte-macrophage colony stimulating factor ( GM-CSF ) on the production of collagen , glycosaminoglycan , [fibronectin] , and collagenase activity by three lines of cultured human adult dermal fibroblasts . Regulation FN1 TNF 7550449 323247 Differential *effects* of on the expression of [fibronectin] and collagen genes in cultured bovine endothelial cells . Regulation FN1 TNF 7550449 323248 The *effects* of recombinant human on the expression of [fibronectin] and types ( IV ) , ( III ) , and ( I ) procollagen genes in cultured bovine pulmonary artery endothelial cells were examined in this study . Regulation FN1 TNF 7896895 299976 Thus , our studies suggest that vascular SMC [fibronectin] synthesis is *regulated* by reciprocal induction of IL-1 beta and activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Regulation FN1 TNF 8466280 216020 The *effects* of on collagens I , III and VI , [fibronectin] and collagenase gene expression by fibroblasts derived from normal individuals and patients with systemic sclerosis ( SSc ) were studied . Regulation FN1 TNF 9443093 475270 When MC were cultured with PBMC supernatants from patients , levels in PBMC supernatants correlated with production of MCP-1 or fibronectin by MC. PBMC supernatants obtained from patients with MCD and MN decreased MCP-1 production by MC , but did not *affect* thymidine incorporation or [fibronectin] production by MC. Sera obtained from patients with DN and MCD reduced thymidine incorporation in MC . Regulation FNDC5 PGC 24120943 2863713 Neuronal [Fndc5] gene expression is *regulated* by , and Pgc1a ( -/- ) mice show reduced Fndc5 expression in the brain . Regulation FOLR1 ADCY1 8001792 283846 Glucose repression of [fbp1] transcription of Schizosaccharomyces pombe is partially *regulated* by activation by a G protein alpha subunit encoded by gpa2 ( git8 ) . Regulation FOLR1 ADCY10 8001792 283845 Glucose repression of [fbp1] transcription of Schizosaccharomyces pombe is partially *regulated* by activation by a G protein alpha subunit encoded by gpa2 ( git8 ) . Regulation FOLR1 ADCY2 8001792 283847 Glucose repression of [fbp1] transcription of Schizosaccharomyces pombe is partially *regulated* by activation by a G protein alpha subunit encoded by gpa2 ( git8 ) . Regulation FOLR1 ADCY3 8001792 283848 Glucose repression of [fbp1] transcription of Schizosaccharomyces pombe is partially *regulated* by activation by a G protein alpha subunit encoded by gpa2 ( git8 ) . Regulation FOLR1 ADCY4 8001792 283849 Glucose repression of [fbp1] transcription of Schizosaccharomyces pombe is partially *regulated* by activation by a G protein alpha subunit encoded by gpa2 ( git8 ) . Regulation FOLR1 ADCY5 8001792 283850 Glucose repression of [fbp1] transcription of Schizosaccharomyces pombe is partially *regulated* by activation by a G protein alpha subunit encoded by gpa2 ( git8 ) . Regulation FOLR1 ADCY6 8001792 283851 Glucose repression of [fbp1] transcription of Schizosaccharomyces pombe is partially *regulated* by activation by a G protein alpha subunit encoded by gpa2 ( git8 ) . Regulation FOLR1 ADCY7 8001792 283852 Glucose repression of [fbp1] transcription of Schizosaccharomyces pombe is partially *regulated* by activation by a G protein alpha subunit encoded by gpa2 ( git8 ) . Regulation FOLR1 ADCY8 8001792 283853 Glucose repression of [fbp1] transcription of Schizosaccharomyces pombe is partially *regulated* by activation by a G protein alpha subunit encoded by gpa2 ( git8 ) . Regulation FOLR1 ADCY9 8001792 283854 Glucose repression of [fbp1] transcription of Schizosaccharomyces pombe is partially *regulated* by activation by a G protein alpha subunit encoded by gpa2 ( git8 ) . Regulation FOLR1 FOLR2 14608093 1162228 In addition , the *effect* of on folate bioaccessibility and the stability of [FBP] added to yogurt during gastrointestinal passage were investigated . Regulation FOLR1 HNF4A 19180647 2054087 We have identified a transcriptional enhancer sequence from the FOLR1 locus with specific activity in vitro and in vivo , and suggest that [FOLR1] is a *target* for regulation by . Regulation FOS EPHB2 12972619 1139615 Furthermore , we provide evidence that the *dependent* activation of [c-Fos] is an integral component of the mitogenic pathway by which PDGF regulates normal and aberrant cell growth . Regulation FOS EPHB2 15063796 1230995 TPA stimulated *dependent* increases in [c-Fos] protein and the c-Fos content of AP-1 complexes . Regulation FOS EPHB2 15193999 1259712 These results suggest that FK960 stimulates GDNF production in c-Fos- and CREB dependent mechanisms in cultured astrocytes and that signal is *responsible* for both [c-Fos] expression and CREB phosphorylation in the cascades . Regulation FOS EPHB2 15615716 1375496 Additional experiments reveal that , in conjunction with p65 NF-kappaB , the *dependent* synthesis of [c-Fos] and Fra-1 serves to adjust the overall expression level of IL-8 in response to two of its physiological inducers , IL-1 and epidermal growth factor . Regulation FOS EPHB2 16115217 1448853 Additionally , chronic blocking of activation *affected* cocaine induced [c-Fos] and JunB but not Zif268 expression . Regulation FOS EPHB2 17052890 1700325 In CCl39 fibroblasts , sustained ERK1/2 activation is required for the expression of Fra-1 , Fra-2 , c-Jun and JunB , whereas expression of [c-Fos] is still strongly induced even in *response* to transient activation . Regulation FOS EPHB2 19935718 2210118 In addition , OHT induced *dependent* expression of [c-Fos] and transactivation of an AP-1-responsive promoter . Regulation FOS EPHB2 23018815 2698176 is *involved* in tooth-pressure induced [Fos] expression in Vc neurons . Regulation FOS IL1B 12133574 966963 Inhibitory *effects* of intrathecally administered on carrageenan induced hyperalgesia and spinal [c-Fos] expression in rats . Regulation FOS IL1B 17496810 1739504 This study investigated the *role* of in the expression of [Fos] , a marker of neuronal activation , and hyperalgesia caused by injecting complete Freund 's adjuvant into one hind paw of the rat . Regulation FOS TNFSF10 10777594 686903 This inhibition can be accounted for by the specific cleavage by caspase 3 of the SRF both in vitro and in vivo , since acetyl-DEVD-aldehyde prevented SRF cleavage and abolished the inhibitory *effect* of CH11 and on the [c-FOS] promoter activity . Regulation FOSL1 EPHB2 11756554 899158 These observations suggest that *dependent* activation of [Fra-1] is required for AP-1 transactivation in JB6 cells . Regulation FOSL1 EPHB2 12414630 1011046 In summary , we demonstrate that *dependent* [Fra-1] is elevated in AP-1 complexes in response to asbestos fibers and is critical to the transformation of mesothelial cells . Regulation FOSL1 EPHB2 12892714 1117848 The Fos family member [Fra-1] is expressed in an *dependent* manner . Regulation FOSL1 EPHB2 15615716 1375494 Additional experiments reveal that , in conjunction with p65 NF-kappaB , the *dependent* synthesis of c-Fos and [Fra-1] serves to adjust the overall expression level of IL-8 in response to two of its physiological inducers , IL-1 and epidermal growth factor . Regulation FOSL1 EPHB2 9858556 582054 Treatment of Ras transformed cells with the MEK inhibitor PD098059 blocks expression of Fra-1 and Fra-2 , showing that in Ras transformation signalling is *responsible* for [Fra-1] and Fra-2 expression . Regulation FOSL1 MMP28 18288638 1911814 Furthermore , [Fra-1] induced EGFR phosphorylation in an *dependent* manner , and an EGFR-specific inhibitor was able to block Fra-1 enhanced cell motility and invasion . Regulation FOSL1 MMP7 18288638 1911829 Furthermore , [Fra-1] induced EGFR phosphorylation in an *dependent* manner , and an EGFR-specific inhibitor was able to block Fra-1 enhanced cell motility and invasion . Regulation FOSL2 EPHB2 20039427 2192724 Stimulation with TGFbeta and platelet derived growth factor ( PDGF ) significantly increased the expression of Fra-2 in SSc fibroblasts and induced DNA binding of [Fra-2] in an *dependent* manner . Regulation FOSL2 EPHB2 9858556 582055 Treatment of Ras transformed cells with the MEK inhibitor PD098059 blocks expression of Fra-1 and Fra-2 , showing that in Ras transformation signalling is *responsible* for Fra-1 and [Fra-2] expression . Regulation FOXA1 AP2A1 22577344 2598135 In one process , ErbB2 signaling genes CREB1 and c-Fos regulate FOXA1 transcription , and in another process , *regulates* the expression of both [FOXA1] and ErbB2 . Regulation FOXA1 AP2M1 22577344 2598136 In one process , ErbB2 signaling genes CREB1 and c-Fos regulate FOXA1 transcription , and in another process , *regulates* the expression of both [FOXA1] and ErbB2 . Regulation FOXA1 FOXA2 11027295 738861 These changes in gene transcription may result from the disruptive *effect* of on the hepatic expression of the endogenous mouse [HNF-3alpha] , -3beta , -3gamma , and -6 transcription factors . Regulation FOXA1 FOXA2 18048911 1833166 [FoxA(1)] probably regulates its own production , and it *controls* the production of as well . Regulation FOXA1 INS 20068169 2193987 The *effects* of on GATA-3 and [FOXA1] could be recapitulated through overexpression of T-bet in MCF-7 cells ( MCF-7-T-bet ) . Regulation FOXA1 MLXIPL 20534694 2295595 expression is directly *controlled* by [Foxa1] and Foxa2 in both the fetal endocrine pancreas as well as mature islets . Regulation FOXA1 MYLIP 24486549 2918552 The microRNA *regulates* lung [FoxA1] expression during lipopolysaccharide induced acute lung injury . Regulation FOXA1 NEUROG2 17596284 1768247 During specification , [Foxa1] and Foxa2 *regulate* the extent of neurogenesis in mDA progenitors by positively regulating ( Neurog2 ) expression . Regulation FOXA1 ONECUT1 15562441 1343456 We investigated how *controls* the expression of [Foxa1] . Regulation FOXA1 PAX4 11845228 912440 In contrast , had no *effect* on Cdx-2/3 or [HNF3alpha] mediated transcriptional activation . Regulation FOXA1 SOX2 25016694 2948468 To further verify the transcriptional regulation *effect* of on [FOXA1] and elucidate its application in the diagnosis of human lung and breast cancer , we performed real-time RT-PCR and Western blotting to test the regulation effect of SOX2 on the expression of FOXA1 gene . Regulation FOXA1 SOX2 25016694 2948469 The results showed that there is an inhibitory *effect* of on the expression of [FOXA1] gene . Regulation FOXA2 FOXA1 18048911 1833167 probably regulates its own production , and it *controls* the production of [FoxA(2)] as well . Regulation FOXE1 TNF 10465294 640562 In the present study , we examine the *effects* of and IFN-gamma on [TTF-2] gene expression , as well as the DNA binding activity of TTF-2 . Regulation FOXE1 TNF 10465294 640566 The suppressive *effects* of and IFN-gamma on [TTF-2] mRNA levels were concentration dependent and maximal at 50 ng/ml TNF-alpha with 100 U/ml IFN-gamma . Regulation FOXM1 FOXA1 7862129 296154 We also discuss the *role* of reduced expression in mediating decreased transcription of [HNF-3] target genes which respond negatively to cytokine signalling . Regulation FOXO1 ADCY1 19651894 2132426 In this study , we demonstrate that Drosophila melanogaster [FoxO] ( dFoxO ) *regulates* cAMP signaling by directly inducing the expression of an gene , ac76e . Regulation FOXO1 ADCY10 19651894 2132425 In this study , we demonstrate that Drosophila melanogaster [FoxO] ( dFoxO ) *regulates* cAMP signaling by directly inducing the expression of an gene , ac76e . Regulation FOXO1 ADCY2 19651894 2132427 In this study , we demonstrate that Drosophila melanogaster [FoxO] ( dFoxO ) *regulates* cAMP signaling by directly inducing the expression of an gene , ac76e . Regulation FOXO1 ADCY3 19651894 2132428 In this study , we demonstrate that Drosophila melanogaster [FoxO] ( dFoxO ) *regulates* cAMP signaling by directly inducing the expression of an gene , ac76e . Regulation FOXO1 ADCY4 19651894 2132429 In this study , we demonstrate that Drosophila melanogaster [FoxO] ( dFoxO ) *regulates* cAMP signaling by directly inducing the expression of an gene , ac76e . Regulation FOXO1 ADCY5 19651894 2132430 In this study , we demonstrate that Drosophila melanogaster [FoxO] ( dFoxO ) *regulates* cAMP signaling by directly inducing the expression of an gene , ac76e . Regulation FOXO1 ADCY6 19651894 2132431 In this study , we demonstrate that Drosophila melanogaster [FoxO] ( dFoxO ) *regulates* cAMP signaling by directly inducing the expression of an gene , ac76e . Regulation FOXO1 ADCY7 19651894 2132432 In this study , we demonstrate that Drosophila melanogaster [FoxO] ( dFoxO ) *regulates* cAMP signaling by directly inducing the expression of an gene , ac76e . Regulation FOXO1 ADCY8 19651894 2132433 In this study , we demonstrate that Drosophila melanogaster [FoxO] ( dFoxO ) *regulates* cAMP signaling by directly inducing the expression of an gene , ac76e . Regulation FOXO1 ADCY9 19651894 2132434 In this study , we demonstrate that Drosophila melanogaster [FoxO] ( dFoxO ) *regulates* cAMP signaling by directly inducing the expression of an gene , ac76e . Regulation FOXO1 AKT1 10358014 618620 Negative *regulation* of the forkhead transcription factor [FKHR] by . Regulation FOXO1 AKT1 10358014 618629 We have examined the possible *role* of in the regulation of [FKHR] . Regulation FOXO1 AKT1 10358014 618639 These results suggest that [FKHR] may be a direct nuclear regulatory *target* for in both metabolic and cell survival pathways . Regulation FOXO1 AKT1 10602488 574785 *Regulation* of the forkhead transcription factor [FKHR] , but not the PAX3-FKHR fusion protein , by the serine/threonine kinase . Regulation FOXO1 AKT1 10602488 574806 Importantly , Akt inhibited the translocation of FKHR to the nucleus , providing a mechanism by which might *regulate* the transcriptional activity of [FKHR] . Regulation FOXO1 AKT1 11467835 840759 [FKHR] was phosphorylated in a PI 3-kinase- and *dependent* manner , and was translocated from the nucleus to the cytoplasm in response to insulin . Regulation FOXO1 AKT1 12114024 963912 Recent discoveries about [FOXO] *regulation* by signalling suggest that the PI3K-PKB-FOXO pathway might participate in similar processes in higher eukaryotes . Regulation FOXO1 AKT1 15256269 1272086 The transcription factor [FKHR] ( FOXO1a ) is *regulated* by and insulin controls the expression of hepatic genes like glucose-6-phosphatase (G6Pase) at least in part via these proteins . Regulation FOXO1 AKT1 15256269 1272093 The present data demonstrate that activation of is sufficient to mimic the effect of insulin on the expression of G6Pase and that [FKHR] *acts* as an activator of the G6Pase gene indicating that the established cellular models are suitable for the specific analysis of downstream targets of these signaling molecules . Regulation FOXO1 AKT1 16203862 1483227 To determine whether the regulation of [FoxO1] was *dependent* , we next treated Akt2 -/- and wild-type mice with or without insulin . Regulation FOXO1 AKT1 16679294 1559331 Insulin signaling inhibits liver glucose production by inducing nuclear exclusion of the gluconeogenic transcription factor [FOXO1] in an *dependent* manner . Regulation FOXO1 AKT1 17215387 1681957 Our results raise the possibility that neurofibroma formation in individuals with neurofibromatosis might result in part from a *dependent* inhibition of [FOXO] within Schwann cells . Regulation FOXO1 AKT1 17433823 1728991 In response to E2 , phosphorylation of on Ser473 and FOXO1 on Ser256 and Thr24 residues increased but with distinct kinetics , *regulating* the activation and inactivation of Akt and [FOXO1] proteins , respectively . Regulation FOXO1 AKT1 18644889 1942099 In conclusion , estradiol induced *dependent* phosphorylation of [FKHR] drives its association with ERalpha , thereby triggering complex export from the nucleus necessary for initiation of DNA synthesis and S phase entry . Regulation FOXO1 AKT1 19026986 2017151 Here we show that tumor necrosis factor (TNF)-alpha treatment attenuated *dependent* phosphorylation of [Foxo1] and enhanced transcriptional activity of Foxo1 . Regulation FOXO1 AKT1 19389373 2069968 These findings indicate that positively regulates the cellular processes of skeletal growth and endochondral ossification , that the Akt-mTOR , [Akt-FoxO] , and Akt-GSK3 pathways positively or negatively *regulate* the cellular processes , and that Akt exerts its function in skeletal development by tuning the three pathways in a manner dependent on the skeletal part . Regulation FOXO1 AKT1 19470406 2097478 In this study , we found that TRAIL inhibited *dependent* [FoxO] phosphorylation and relocated FoxO proteins into the nucleus from the cytosol in activated human hepatic stellate LX-2 cells . Regulation FOXO1 AKT1 20657733 2293395 Our results also provide evidence that , as in bilaterian animals , Hydra [FoxO] activity is *regulated* by both and JNK kinases . Regulation FOXO1 AKT1 21389279 2431895 Although the *regulation* of [FOXO] by is well evidenced in skeletal muscle , the current study demonstrates that FOXO is also regulated in muscle via the histone acetyltransferase ( HAT ) activities of p300/CREB binding protein (CBP) . Regulation FOXO1 AKT1 21708191 2476019 The present review summarizes the current knowledge of [FoxO] *regulation* by and 14-3-3 proteins , focusing on its mechanistic and structural aspects and discusses its crosstalk with the other FoxO regulatory mechanisms . Regulation FOXO1 AKT1 22185211 2612197 Furthermore , the combination of curcumin and L-ASP led to significant reductions in phosphorylated AKT and expression of *regulated* gene products ( [FoxO1] , GSK3ß , IKKa , NF-?B , XIAP ) compared with the group treated with only L-ASP and the control group . Regulation FOXO1 AKT1 22224971 2544537 In addition , Xanthigen may also stimulate insulin trigger signaling and result in *dependent* phosphorylation of [forkhead/winged helix O (FoxO)1] and FoxO3a . Regulation FOXO1 AKT1 22333587 2642922 Thus , *regulation* of the PAX3- [FKHR] suppresses myogenic gene expression in ARMS cells , causing a failure in differentiation . Regulation FOXO1 AKT1 22552808 2618870 In conclusion , thrombin and FoxO factors functionally interact through *dependent* [FoxO] phosphorylation leading to expression of cell cycle regulating genes and ultimately SMC proliferation . Regulation FOXO1 AKT1 24705403 2949474 *dependent* phosphorylation of hepatic [FoxO1] is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet induced obesity . Regulation FOXO1 AKT2 10358014 618621 Negative *regulation* of the forkhead transcription factor [FKHR] by . Regulation FOXO1 AKT2 10358014 618630 We have examined the possible *role* of in the regulation of [FKHR] . Regulation FOXO1 AKT2 10358014 618640 These results suggest that [FKHR] may be a direct nuclear regulatory *target* for in both metabolic and cell survival pathways . Regulation FOXO1 AKT2 10602488 574786 *Regulation* of the forkhead transcription factor [FKHR] , but not the PAX3-FKHR fusion protein , by the serine/threonine kinase . Regulation FOXO1 AKT2 10602488 574807 Importantly , Akt inhibited the translocation of FKHR to the nucleus , providing a mechanism by which might *regulate* the transcriptional activity of [FKHR] . Regulation FOXO1 AKT2 11467835 840760 [FKHR] was phosphorylated in a PI 3-kinase- and *dependent* manner , and was translocated from the nucleus to the cytoplasm in response to insulin . Regulation FOXO1 AKT2 16203862 1483228 To determine whether the regulation of [FoxO1] was *dependent* , we next treated Akt2 -/- and wild-type mice with or without insulin . Regulation FOXO1 AKT2 16679294 1559332 Insulin signaling inhibits liver glucose production by inducing nuclear exclusion of the gluconeogenic transcription factor [FOXO1] in an *dependent* manner . Regulation FOXO1 AKT2 17215387 1681958 Our results raise the possibility that neurofibroma formation in individuals with neurofibromatosis might result in part from a *dependent* inhibition of [FOXO] within Schwann cells . Regulation FOXO1 AKT2 17433823 1728992 In response to E2 , phosphorylation of on Ser473 and FOXO1 on Ser256 and Thr24 residues increased but with distinct kinetics , *regulating* the activation and inactivation of Akt and [FOXO1] proteins , respectively . Regulation FOXO1 AKT2 18644889 1942100 In conclusion , estradiol induced *dependent* phosphorylation of [FKHR] drives its association with ERalpha , thereby triggering complex export from the nucleus necessary for initiation of DNA synthesis and S phase entry . Regulation FOXO1 AKT2 19026986 2017152 Here we show that tumor necrosis factor (TNF)-alpha treatment attenuated *dependent* phosphorylation of [Foxo1] and enhanced transcriptional activity of Foxo1 . Regulation FOXO1 AKT2 19389373 2069969 These findings indicate that positively regulates the cellular processes of skeletal growth and endochondral ossification , that the Akt-mTOR , [Akt-FoxO] , and Akt-GSK3 pathways positively or negatively *regulate* the cellular processes , and that Akt exerts its function in skeletal development by tuning the three pathways in a manner dependent on the skeletal part . Regulation FOXO1 AKT2 19470406 2097479 In this study , we found that TRAIL inhibited *dependent* [FoxO] phosphorylation and relocated FoxO proteins into the nucleus from the cytosol in activated human hepatic stellate LX-2 cells . Regulation FOXO1 AKT2 20657733 2293396 Our results also provide evidence that , as in bilaterian animals , Hydra [FoxO] activity is *regulated* by both and JNK kinases . Regulation FOXO1 AKT2 21389279 2431896 Although the *regulation* of [FOXO] by is well evidenced in skeletal muscle , the current study demonstrates that FOXO is also regulated in muscle via the histone acetyltransferase ( HAT ) activities of p300/CREB binding protein (CBP) . Regulation FOXO1 AKT2 21708191 2476020 The present review summarizes the current knowledge of [FoxO] *regulation* by and 14-3-3 proteins , focusing on its mechanistic and structural aspects and discusses its crosstalk with the other FoxO regulatory mechanisms . Regulation FOXO1 AKT2 22185211 2612198 Furthermore , the combination of curcumin and L-ASP led to significant reductions in phosphorylated AKT and expression of *regulated* gene products ( [FoxO1] , GSK3ß , IKKa , NF-?B , XIAP ) compared with the group treated with only L-ASP and the control group . Regulation FOXO1 AKT2 22224971 2544538 In addition , Xanthigen may also stimulate insulin trigger signaling and result in *dependent* phosphorylation of [forkhead/winged helix O (FoxO)1] and FoxO3a . Regulation FOXO1 AKT2 22333587 2642923 Thus , *regulation* of the PAX3- [FKHR] suppresses myogenic gene expression in ARMS cells , causing a failure in differentiation . Regulation FOXO1 AKT2 22552808 2618871 In conclusion , thrombin and FoxO factors functionally interact through *dependent* [FoxO] phosphorylation leading to expression of cell cycle regulating genes and ultimately SMC proliferation . Regulation FOXO1 AKT2 24705403 2949475 *dependent* phosphorylation of hepatic [FoxO1] is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet induced obesity . Regulation FOXO1 AKT3 10358014 618622 Negative *regulation* of the forkhead transcription factor [FKHR] by . Regulation FOXO1 AKT3 10358014 618631 We have examined the possible *role* of in the regulation of [FKHR] . Regulation FOXO1 AKT3 10358014 618641 These results suggest that [FKHR] may be a direct nuclear regulatory *target* for in both metabolic and cell survival pathways . Regulation FOXO1 AKT3 10602488 574787 *Regulation* of the forkhead transcription factor [FKHR] , but not the PAX3-FKHR fusion protein , by the serine/threonine kinase . Regulation FOXO1 AKT3 10602488 574808 Importantly , Akt inhibited the translocation of FKHR to the nucleus , providing a mechanism by which might *regulate* the transcriptional activity of [FKHR] . Regulation FOXO1 AKT3 11467835 840761 [FKHR] was phosphorylated in a PI 3-kinase- and *dependent* manner , and was translocated from the nucleus to the cytoplasm in response to insulin . Regulation FOXO1 AKT3 16203862 1483229 To determine whether the regulation of [FoxO1] was *dependent* , we next treated Akt2 -/- and wild-type mice with or without insulin . Regulation FOXO1 AKT3 16679294 1559333 Insulin signaling inhibits liver glucose production by inducing nuclear exclusion of the gluconeogenic transcription factor [FOXO1] in an *dependent* manner . Regulation FOXO1 AKT3 17215387 1681959 Our results raise the possibility that neurofibroma formation in individuals with neurofibromatosis might result in part from a *dependent* inhibition of [FOXO] within Schwann cells . Regulation FOXO1 AKT3 17433823 1728993 In response to E2 , phosphorylation of on Ser473 and FOXO1 on Ser256 and Thr24 residues increased but with distinct kinetics , *regulating* the activation and inactivation of Akt and [FOXO1] proteins , respectively . Regulation FOXO1 AKT3 18644889 1942101 In conclusion , estradiol induced *dependent* phosphorylation of [FKHR] drives its association with ERalpha , thereby triggering complex export from the nucleus necessary for initiation of DNA synthesis and S phase entry . Regulation FOXO1 AKT3 19026986 2017153 Here we show that tumor necrosis factor (TNF)-alpha treatment attenuated *dependent* phosphorylation of [Foxo1] and enhanced transcriptional activity of Foxo1 . Regulation FOXO1 AKT3 19389373 2069970 These findings indicate that positively regulates the cellular processes of skeletal growth and endochondral ossification , that the Akt-mTOR , [Akt-FoxO] , and Akt-GSK3 pathways positively or negatively *regulate* the cellular processes , and that Akt exerts its function in skeletal development by tuning the three pathways in a manner dependent on the skeletal part . Regulation FOXO1 AKT3 19470406 2097480 In this study , we found that TRAIL inhibited *dependent* [FoxO] phosphorylation and relocated FoxO proteins into the nucleus from the cytosol in activated human hepatic stellate LX-2 cells . Regulation FOXO1 AKT3 20657733 2293397 Our results also provide evidence that , as in bilaterian animals , Hydra [FoxO] activity is *regulated* by both and JNK kinases . Regulation FOXO1 AKT3 21389279 2431897 Although the *regulation* of [FOXO] by is well evidenced in skeletal muscle , the current study demonstrates that FOXO is also regulated in muscle via the histone acetyltransferase ( HAT ) activities of p300/CREB binding protein (CBP) . Regulation FOXO1 AKT3 21708191 2476021 The present review summarizes the current knowledge of [FoxO] *regulation* by and 14-3-3 proteins , focusing on its mechanistic and structural aspects and discusses its crosstalk with the other FoxO regulatory mechanisms . Regulation FOXO1 AKT3 22185211 2612199 Furthermore , the combination of curcumin and L-ASP led to significant reductions in phosphorylated AKT and expression of *regulated* gene products ( [FoxO1] , GSK3ß , IKKa , NF-?B , XIAP ) compared with the group treated with only L-ASP and the control group . Regulation FOXO1 AKT3 22224971 2544539 In addition , Xanthigen may also stimulate insulin trigger signaling and result in *dependent* phosphorylation of [forkhead/winged helix O (FoxO)1] and FoxO3a . Regulation FOXO1 AKT3 22333587 2642924 Thus , *regulation* of the PAX3- [FKHR] suppresses myogenic gene expression in ARMS cells , causing a failure in differentiation . Regulation FOXO1 AKT3 22552808 2618872 In conclusion , thrombin and FoxO factors functionally interact through *dependent* [FoxO] phosphorylation leading to expression of cell cycle regulating genes and ultimately SMC proliferation . Regulation FOXO1 AKT3 24705403 2949476 *dependent* phosphorylation of hepatic [FoxO1] is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet induced obesity . Regulation FOXO1 CAPN1 19029949 2029346 PP2A associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is involved in mediated [FoxO] *regulation* . Regulation FOXO1 CAPN10 19029949 2029347 PP2A associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is involved in mediated [FoxO] *regulation* . Regulation FOXO1 CAPN11 19029949 2029348 PP2A associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is involved in mediated [FoxO] *regulation* . Regulation FOXO1 CAPN12 19029949 2029345 PP2A associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is involved in mediated [FoxO] *regulation* . Regulation FOXO1 CAPN13 19029949 2029356 PP2A associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is involved in mediated [FoxO] *regulation* . Regulation FOXO1 CAPN14 19029949 2029357 PP2A associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is involved in mediated [FoxO] *regulation* . Regulation FOXO1 CAPN15 19029949 2029344 PP2A associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is involved in mediated [FoxO] *regulation* . Regulation FOXO1 CAPN2 19029949 2029349 PP2A associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is involved in mediated [FoxO] *regulation* . Regulation FOXO1 CAPN3 19029949 2029350 PP2A associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is involved in mediated [FoxO] *regulation* . Regulation FOXO1 CAPN5 19029949 2029351 PP2A associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is involved in mediated [FoxO] *regulation* . Regulation FOXO1 CAPN6 19029949 2029352 PP2A associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is involved in mediated [FoxO] *regulation* . Regulation FOXO1 CAPN7 19029949 2029353 PP2A associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is involved in mediated [FoxO] *regulation* . Regulation FOXO1 CAPN8 19029949 2029354 PP2A associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is involved in mediated [FoxO] *regulation* . Regulation FOXO1 CAPN9 19029949 2029355 PP2A associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is involved in mediated [FoxO] *regulation* . Regulation FOXO1 CCR7 19136962 2025515 In naive T cells , [Foxo1] *controlled* the expression of the adhesion molecule L-selectin , the chemokine receptor and the transcription factor Klf2 , and its deletion was sufficient to alter lymphocyte trafficking . Regulation FOXO1 CD8A 23932570 2830923 The transcription factor [Foxo1] *controls* central-memory T cell responses to infection . Regulation FOXO1 CDK2 17038621 1631021 *dependent* phosphorylation of [FOXO1] as an apoptotic response to DNA damage . Regulation FOXO1 CDK4 23469153 2750286 Our findings indicate that phosphorylates and positively *regulates* [PAX3-FOXO1] and suggest that inhibition of Cdk4 activity should be explored as a promising avenue for developing therapy for ARMS . Regulation FOXO1 CEBPA 17627282 1779960 Foxo1 bound C/EBPalpha via its forkhead domain , and [Foxo1] bound to the promoter of a gluconeogenic gene , phosphoenolpyruvate carboxykinase ( PEPCK ) , in a *dependent* manner in vivo . Regulation FOXO1 DEFA1B 18347011 1898383 In isolated primary hepatocytes , we studied the *effect* of and -2 on glucose production , expression of gluconeogenic genes , and phosphorylation of Akt , c-Src , and [FoxO1] . Regulation FOXO1 DMD 17786240 1790853 To examine the *involvement* of the in regulation of [Foxo] activities and muscle atrophy , we analyzed the expression of DGC members during tail suspension , a model of unloading induced muscle atrophy . Regulation FOXO1 E2F1 17482685 1738751 *regulates* expression of [FOXO1] and FOXO3a . Regulation FOXO1 EDN1 22570335 2619216 To understand the underlying mechanism , we studied the *effect* of on endothelial production of [Forkhead box O1 (FOXO1)] , a forkhead transcription factor that plays an important role in cell survival . Regulation FOXO1 EDN1 22570335 2619218 In *response* to , [FOXO1] was phosphorylated and translocated from the nucleus to cytoplasm , resulting in inhibition of BAD production and mitigation of FOXO1 mediated apoptosis . Regulation FOXO1 FASN 24478438 2927954 Further investigation suggested that the expression of SREBP-1c and is *controlled* by the transcription factor [FoxO1] during HCV infection . Regulation FOXO1 FLI1 20933505 2343358 To better understand how *affects* [FOXO1] expression , we have established a doxycycline-inducible siRNA system to achieve stable and reversible knockdown of EWS-Fli1 in Ewing 's sarcoma cells . Regulation FOXO1 FLI1 23995784 2948772 In addition to [FOXO1] *regulation* by direct promoter binding of , its subcellular localization and activity is regulated by cyclin dependent kinase 2- and AKT mediated phosphorylation downstream of EWS-FLI1 . Regulation FOXO1 FOXA2 21385937 2416142 Dynamic *regulation* of PDX-1 and [FoxO1] expression by in dexamethasone induced pancreatic ß-cells dysfunction . Regulation FOXO1 FOXA2 21385937 2416146 Further study showed that was *involved* in regulation of [FoxO1] and PDX-1 expression in DEX induced pancreatic ß-cells dysfunction . Regulation FOXO1 FOXA2 21385937 2416150 Interestingly , we demonstrated for the first time that could bind to the FoxO1 gene promoter and positively *regulate* [FoxO1] expression . Regulation FOXO1 FOXA2 21385937 2416155 Together , the results of the present study demonstrated that could dynamically *regulate* [FoxO1] and PDX-1 expression in pancreatic ß-cells treated with DEX , which provides new important information on the transcriptional regulation of FoxO1 and PDX-1 in DEX induced pancreatic ß-cells . Regulation FOXO1 FOXC1 17993506 1860078 *regulates* the expression of [FOXO1A] and binds to a conserved element in the FOXO1A promoter in vivo . Regulation FOXO1 GLUL 22996802 2702175 Furthermore , [FOXO] activation induces autophagosome formation and autophagic flux in a *dependent* manner . Regulation FOXO1 GOLPH3 22675169 2633143 Western blotting and luciferase reporter analyses were used to investigate the *effect* of overexpression and silencing on the expression of cell-cycle regulators and [FOXO1] transcriptional activity . Regulation FOXO1 HRAS 17215387 1681960 Our results raise the possibility that neurofibroma formation in individuals with neurofibromatosis might result in part from a *dependent* inhibition of [FOXO] within Schwann cells . Regulation FOXO1 HSPB1 19528257 2142380 In contrast , had no *effect* on [Foxo] transactivation . Regulation FOXO1 IGF1 14710188 1196809 Our results indicate that these residues are targeted by CK1 in vivo and that the CK1 mediated phosphorylation of the MPD is required for accelerated nuclear exclusion of [FOXO1a] in *response* to and insulin . Regulation FOXO1 IGF1 17210752 1681610 Inhibition of phosphatidylinositol 3-kinase/Akt pathway suppressed the *effect* of insulin and on [FOXO1] phosphorylation . Regulation FOXO1 IGF1 21324320 2426299 Longevity increases when [FoxO] becomes activated in *response* to reduced signalling . Regulation FOXO1 IGF1 21991327 2493502 Together , these data demonstrate that *regulation* of [Foxo1] nuclear localization is essential for the myogenic program in L6 cells but that persistent activation of IGF-1 signaling pathways results in a negative feedback to prevent myogenesis . Regulation FOXO1 IGF1R 17210752 1681606 FOXO1 is a member of the forkhead transcriptional factor family , but how insulin and signaling *regulate* [FOXO1] in cardiomyocytes is not well understood . Regulation FOXO1 IL1A 23105097 2706991 The *effects* on [FoxO1] are counteracted , however , by the silencing or inhibition of neutral sphingomyelinase 2 (nSMase-2) using shRNAi , scyphostatin , or GW4869 , as well as by the pharmacological inhibition of JNK and ERK . Regulation FOXO1 IL1A 23105097 2706995 In conclusion , we propose that *regulates* [FoxO1] activity through a novel nSMase-2 dependent pathway . Regulation FOXO1 INS 10347145 616735 Because Akt is phosphorylated in response to insulin and has been implicated in a variety of insulin effects , we investigated whether *affects* phosphorylation of [FKHR] . Regulation FOXO1 INS 10347145 616742 Mutation of serine 253 , located in a consensus Akt phosphorylation site at the carboxyl-terminal end of the forkhead domain , abolished the *effect* of on [FKHR] phosphorylation . Regulation FOXO1 INS 11942857 953537 However , induced phosphorylation and *regulation* of protein kinase B , glycogen synthase kinase-3 and [FKHR] ( forkhead in rhabdomyosarcoma ) are not affected by H ( 2 ) O ( 2 ) in the same cells . Regulation FOXO1 INS 12530968 1048847 The forkhead transcription factor [Foxo1] is *regulated* by via Akt dependent phosphorylation and nuclear exclusion . Regulation FOXO1 INS 12724332 1106609 We conclude that the transcriptional activity of [Foxo1] is *regulated* at different levels by : transactivation , as well as DNA binding and nuclear exclusion . Regulation FOXO1 INS 15256269 1272087 The transcription factor [FKHR] ( FOXO1a ) is *regulated* by protein kinase B (PKB) and controls the expression of hepatic genes like glucose-6-phosphatase (G6Pase) at least in part via these proteins . Regulation FOXO1 INS 15632182 1380909 In parallel , the *effects* of on Akt activation , glycogen synthase kinase 3 , and [FoxO1a] phosphorylation , and glucose secretion were all significantly decreased in CYP2E1 overexpressing cells . Regulation FOXO1 INS 15934941 1414681 [FoxO1] , a member of the FoxO subfamily of forkhead transcription factors , is an important *target* for and growth factor signaling in the regulation of metabolism , cell cycle and proliferation , and survival in peripheral tissues . Regulation FOXO1 INS 16679294 1559335 Through the concomitant application of genome-scale functional screening and quantitative image analysis , we have identified PTP-MEG2 as a modulator of *dependent* [FOXO1] subcellular localization . Regulation FOXO1 INS 17210752 1681607 FOXO1 is a member of the forkhead transcriptional factor family , but how and IGF-I receptor signaling *regulate* [FOXO1] in cardiomyocytes is not well understood . Regulation FOXO1 INS 17210752 1681611 Inhibition of phosphatidylinositol 3-kinase/Akt pathway suppressed the *effect* of and IGF-I on [FOXO1] phosphorylation . Regulation FOXO1 INS 19297333 2073260 In 3T3-L1 adipocytes , *controls* nucleo-cytoplasmic shuttling of [FoxO1] and regulates its interaction with endogenous ATGL promotors . Regulation FOXO1 INS 19651810 2150053 We studied the mechanism by which FoxO1 mediates dependent *regulation* of IL-1ß expression in cultured macrophages and correlated [FoxO1] activity in peritoneal macrophages with IL-1ß production profiles in mice with low-grade inflammation or insulin resistance . Regulation FOXO1 INS 19877183 2187967 TACE overexpression significantly impaired *dependent* phosphorylation of AKT , GSK3 , and [FoxO1] in mouse hepatocytes . Regulation FOXO1 INS 20501674 2294829 Increased FoxO1 activity augments the expression of insulin receptor (IR) and IR substrate (IRS)2 , which in turn inhibits [FoxO1] activity in *response* to reduced action . Regulation FOXO1 INS 20573950 2302948 Transcription factor [FoxO1] is *regulated* dually by and nutrients . Regulation FOXO1 INS 21152033 2356291 SRA in adipocytes increases both glucose uptake and phosphorylation of Akt and [FOXO1] in *response* to . Regulation FOXO1 INS 21298325 2425809 Anti-inflammatory *effect* of in the human hepatoma cell line HepG2 involves decreased transcription of IL-6 target genes and nuclear exclusion of [FOXO1] . Regulation FOXO1 INS 21298325 2425818 Further analysis revealed that *regulates* nuclear localization of [FOXO1] , which is an important co-activator for STAT3 mediated transcription . Regulation FOXO1 INS 21324320 2426300 Longevity increases when [FoxO] becomes activated in *response* to reduced signalling . Regulation FOXO1 INS 22865884 2677422 In summary , we demonstrate that [FOXO1] phosphorylation and cellular localization is *regulated* by signaling in gonadotropes and that FOXO1 inhibits Lhb transcription . Regulation FOXO1 INS 23631196 2779115 [FoxO1] is a downstream *effector* of signaling and Sirt1 is an NAD ( + ) -dependent deacetylase , both of which work as energy sensors at the cellular level . Regulation FOXO1 INS 24065703 2857763 Recently , we reported that *regulates* [FOXO1] phosphorylation and cellular localization in pituitary gonadotropes and that FOXO1 overexpression inhibits Lhb transcription . Regulation FOXO1 IRF3 23532851 2777561 [FoxO1] negatively *regulates* cellular antiviral response by promoting degradation of . Regulation FOXO1 IRF3 23532851 2777564 Our findings thus suggest that [FoxO1] negatively *regulates* cellular antiviral response by promoting ubiquitination and degradation , providing a previously unknown mechanism for control of type I IFN induction and cellular antiviral response . Regulation FOXO1 KLF2 19136962 2025516 In naive T cells , [Foxo1] *controlled* the expression of the adhesion molecule L-selectin , the chemokine receptor CCR7 and the transcription factor , and its deletion was sufficient to alter lymphocyte trafficking . Regulation FOXO1 KRAS 17215387 1681961 Our results raise the possibility that neurofibroma formation in individuals with neurofibromatosis might result in part from a *dependent* inhibition of [FOXO] within Schwann cells . Regulation FOXO1 MAPK3 21747041 2466814 Pharmacological blockade of the mineralocorticoid receptor (MR) with eplerenone or small interfering RNA mediated MR-silencing prevented DHEA induced phosphorylation and its *effects* on [FoxO1] . Regulation FOXO1 MAPK8IP1 23770673 2820262 Furthermore , *regulation* of [FOXO] by RALA and is conserved in C. elegans , where both ral-1 and jip-1 depletion impairs heat shock induced nuclear translocation of the FOXO orthologue DAF16 . Regulation FOXO1 MIR223 22569260 2596966 *regulates* [FOXO1] expression and cell proliferation . Regulation FOXO1 MPL 19465850 2091011 With the help of advances in confocal microscopy , laser scanning microscopy , and personal computer computational power over the last decade , it has become evident that signaling *plays* a role in HSC self-renewal and [AKT-forkhead box O] signaling in HSC dormancy . Regulation FOXO1 MTOR 23116773 2717455 Akt signaling can control skeletal muscle mass through regulation of protein synthesis and [FoxO] *regulation* of protein degradation , and this pathway has been previously identified as a target of androgen signaling . Regulation FOXO1 MYLIP 19574223 2122205 Coordinate *regulation* of [FOXO1] by , miR-96 , and miR-182 in breast cancer cells . Regulation FOXO1 MYLIP 22569260 2596968 Therein , our data suggest that *regulates* [FOXO1] expression and cell proliferation . Regulation FOXO1 MYLIP 24374340 2911729 At the molecular level , our results further revealed that expression of [FOXO1] was negatively *regulated* by . Regulation FOXO1 MYOG 16142327 1451087 Since MyoD affects early myogenesis and *controls* terminal differentiation , a combination of [PAX3-FKHR] and IGF-II synergistically blocks myogenesis at several different stages in differentiation . Regulation FOXO1 NEDD9 21940942 2507180 Deacetylated [FoxO1] *regulates* to prevent macrophage inflammation without causing apoptosis , suggesting a potential novel therapeutic approach to atherosclerosis through FoxO1 deacetylation . Regulation FOXO1 NRAS 17215387 1681962 Our results raise the possibility that neurofibroma formation in individuals with neurofibromatosis might result in part from a *dependent* inhibition of [FOXO] within Schwann cells . Regulation FOXO1 PAK1 12560069 1052729 Furthermore , estrogen induced phosphorylation and perinuclear localization of the cell survival forkhead transcription factor [FKHR] in the cytoplasm in a *dependent* manner . Regulation FOXO1 PAX3 16157701 1455855 In mice , and Pax7 play key roles in muscle cell development and differentiation , and [FoxO1a] *regulates* myoblast differentiation and fusion ; Regulation FOXO1 PAX7 16157701 1455856 In mice , Pax3 and play key roles in muscle cell development and differentiation , and [FoxO1a] *regulates* myoblast differentiation and fusion ; Regulation FOXO1 PI3 16457721 1534393 Long-term starvation and ageing induce *dependent* translocation of [DAF-16/FOXO] to the cytoplasm . Regulation FOXO1 PI3 18226221 1884263 Computational analyses followed by chromatin immunoprecipitations demonstrated FOXO binding to both previously known and novel sites in promoter regions of approximately one-third of the up-regulated genes , consistent with activation of [FOXO1] and FOXO3a in *response* to inhibition of . Regulation FOXO1 PI3 18718910 1974906 In the present study we hypothesized that DHEA may stimulate *dependent* phosphorylation of [FoxO1] in endothelial cells to help regulate endothelial function . Regulation FOXO1 PI3 21335550 2411097 [FoxO1] activity is tightly *controlled* by signaling , resulting in its phosphorylation and nuclear exclusion . Regulation FOXO1 PI3 23684624 2796472 Adiponectin fulfills these functions , independently of its known receptors and signaling pathways , by decreasing [FoxO1] activity in a *dependent* manner . Regulation FOXO1 PIK3CA 11875118 918877 In naïve granulosa cells , both FSH and IGF-I stimulate rapid phosphorylation of [FKHR] at multiple sites causing its redistribution from the nucleus to the cytoplasm in a *dependent* manner . Regulation FOXO1 PIK3CA 12114024 963913 Recent discoveries about [FOXO] *regulation* by signalling suggest that the PI3K-PKB-FOXO pathway might participate in similar processes in higher eukaryotes . Regulation FOXO1 PIK3CA 15618457 1387804 Isoproterenol rapidly induced phosphorylation of Akt and [FKHR] in eosinophils in a *dependent* manner . Regulation FOXO1 PIK3CA 17215387 1681963 Our results raise the possibility that neurofibroma formation in individuals with neurofibromatosis might result in part from a *dependent* inhibition of [FOXO] within Schwann cells . Regulation FOXO1 PIK3CA 17433823 1728997 The present work shows that *plays* a crucial role in the phosphorylation and inactivation of [FOXO1] in vivo , indicating that the regulation of this transcription factor is a more complex event in uterine cells requiring further investigations . Regulation FOXO1 PIK3CA 19043547 1998906 however , neither the link between group II mGluRs and PI3K , nor the role of *dependent* regulation of [Foxo] in the control of neuronal excitability , had been previously reported . Regulation FOXO1 PIK3CA 19470406 2097481 In this study , we found that TRAIL inhibited *dependent* [FoxO] phosphorylation and relocated FoxO proteins into the nucleus from the cytosol in activated human hepatic stellate LX-2 cells . Regulation FOXO1 PIK3CA 21865646 2473426 By conditional inactivation of 3-phosphoinositide dependent protein kinase 1 ( Pdk1 ) and phosphatase and tensin homolog (Pten) in the male germ line , we found that signaling *regulates* [Foxo1] stability and subcellular localization , revealing that the Foxos are pivotal effectors of PI3K-Akt signaling in SSCs . Regulation FOXO1 PIK3CA 22552808 2618873 In conclusion , thrombin and FoxO factors functionally interact through *dependent* [FoxO] phosphorylation leading to expression of cell cycle regulating genes and ultimately SMC proliferation . Regulation FOXO1 PIK3CA 22865884 2677407 We demonstrated that FOXO1 is expressed in murine gonadotrope cells and that insulin signaling increased [FOXO1] phosphorylation and cytoplasmic localization in a *dependent* manner . Regulation FOXO1 PIK3CA 25157276 2954743 In the present study we have investigated the *role* of inhibition on [FOXO1] regulation . Regulation FOXO1 PIK3R1 11875118 918878 In naïve granulosa cells , both FSH and IGF-I stimulate rapid phosphorylation of [FKHR] at multiple sites causing its redistribution from the nucleus to the cytoplasm in a *dependent* manner . Regulation FOXO1 PIK3R1 12114024 963914 Recent discoveries about [FOXO] *regulation* by signalling suggest that the PI3K-PKB-FOXO pathway might participate in similar processes in higher eukaryotes . Regulation FOXO1 PIK3R1 15618457 1387805 Isoproterenol rapidly induced phosphorylation of Akt and [FKHR] in eosinophils in a *dependent* manner . Regulation FOXO1 PIK3R1 17215387 1681964 Our results raise the possibility that neurofibroma formation in individuals with neurofibromatosis might result in part from a *dependent* inhibition of [FOXO] within Schwann cells . Regulation FOXO1 PIK3R1 17433823 1728998 The present work shows that *plays* a crucial role in the phosphorylation and inactivation of [FOXO1] in vivo , indicating that the regulation of this transcription factor is a more complex event in uterine cells requiring further investigations . Regulation FOXO1 PIK3R1 19043547 1998907 however , neither the link between group II mGluRs and PI3K , nor the role of dependent *regulation* of [Foxo] in the control of neuronal excitability , had been previously reported . Regulation FOXO1 PIK3R1 19470406 2097482 In this study , we found that TRAIL inhibited *dependent* [FoxO] phosphorylation and relocated FoxO proteins into the nucleus from the cytosol in activated human hepatic stellate LX-2 cells . Regulation FOXO1 PIK3R1 21865646 2473427 By conditional inactivation of 3-phosphoinositide dependent protein kinase 1 ( Pdk1 ) and phosphatase and tensin homolog (Pten) in the male germ line , we found that signaling *regulates* [Foxo1] stability and subcellular localization , revealing that the Foxos are pivotal effectors of PI3K-Akt signaling in SSCs . Regulation FOXO1 PIK3R1 22552808 2618874 In conclusion , thrombin and FoxO factors functionally interact through *dependent* [FoxO] phosphorylation leading to expression of cell cycle regulating genes and ultimately SMC proliferation . Regulation FOXO1 PIK3R1 22865884 2677408 We demonstrated that FOXO1 is expressed in murine gonadotrope cells and that insulin signaling increased [FOXO1] phosphorylation and cytoplasmic localization in a *dependent* manner . Regulation FOXO1 PIK3R1 25157276 2954744 In the present study we have investigated the *role* of inhibition on [FOXO1] regulation . Regulation FOXO1 PIN1 18794148 1964313 Interestingly , *acts* on [FOXO] through stimulation of the activity of the deubiquitinating enzyme HAUSP/USP7 . Regulation FOXO1 PITX1 24065703 2857774 [FOXO1] suppression of basal Fshb transcription may *involve* because PITX1 interacts with FOXO1 , FOXO1 repression maps to the proximal Fshb promoter containing a PITX1 binding site , PITX1 induction of Fshb or a PITX1 binding element in CV-1 cells is decreased by FOXO1 , and FOXO1 suppresses Pitx1 mRNA and protein levels . Regulation FOXO1 PPARGC1A 19103600 2036398 A transferase complex *regulates* [FoxO] transcription factor activity in response to glucose . Regulation FOXO1 PPP2CA 19029949 2029358 associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is *involved* in calpain mediated [FoxO] regulation . Regulation FOXO1 PPP2R1A 19029949 2029359 associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is *involved* in calpain mediated [FoxO] regulation . Regulation FOXO1 PPP2R2B 19029949 2029360 associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is *involved* in calpain mediated [FoxO] regulation . Regulation FOXO1 PRKAA1 17900900 1803031 Lastly , we find that AMPK activates FOXO/DAF-16 dependent transcription and phosphorylates FOXO/DAF-16 at previously unidentified sites , suggesting a possible direct mechanism of *regulation* of [FOXO/DAF-16] by . Regulation FOXO1 PRKAA2 17900900 1803032 Lastly , we find that AMPK activates FOXO/DAF-16 dependent transcription and phosphorylates FOXO/DAF-16 at previously unidentified sites , suggesting a possible direct mechanism of *regulation* of [FOXO/DAF-16] by . Regulation FOXO1 PRKAB1 17900900 1803033 Lastly , we find that AMPK activates FOXO/DAF-16 dependent transcription and phosphorylates FOXO/DAF-16 at previously unidentified sites , suggesting a possible direct mechanism of *regulation* of [FOXO/DAF-16] by . Regulation FOXO1 PRKAB2 17900900 1803034 Lastly , we find that AMPK activates FOXO/DAF-16 dependent transcription and phosphorylates FOXO/DAF-16 at previously unidentified sites , suggesting a possible direct mechanism of *regulation* of [FOXO/DAF-16] by . Regulation FOXO1 PRKAG1 17900900 1803035 Lastly , we find that AMPK activates FOXO/DAF-16 dependent transcription and phosphorylates FOXO/DAF-16 at previously unidentified sites , suggesting a possible direct mechanism of *regulation* of [FOXO/DAF-16] by . Regulation FOXO1 PRKAG2 17900900 1803036 Lastly , we find that AMPK activates FOXO/DAF-16 dependent transcription and phosphorylates FOXO/DAF-16 at previously unidentified sites , suggesting a possible direct mechanism of *regulation* of [FOXO/DAF-16] by . Regulation FOXO1 PRMT1 18951090 1982496 Here we show a paradigm of [FOXO1] *regulation* by the protein arginine methyltransferase . Regulation FOXO1 PTMS 20567500 2280161 [FOXO] activity is *regulated* by multiple that affect its subcellular localization , half-life , DNA binding and transcriptional activity . Regulation FOXO1 RALA 23770673 2820246 The small GTPase *controls* c-Jun N-terminal kinase mediated [FOXO] activation by regulation of a JIP1 scaffold complex . Regulation FOXO1 RALA 23770673 2820263 Furthermore , *regulation* of [FOXO] by and JIP1 is conserved in C. elegans , where both ral-1 and jip-1 depletion impairs heat shock induced nuclear translocation of the FOXO orthologue DAF16 . Regulation FOXO1 RENBP 16457721 1534394 Long-term starvation and ageing induce 3-kinase *dependent* translocation of [DAF-16/FOXO] to the cytoplasm . Regulation FOXO1 SELL 18713968 1950752 We now report that [FOXO1] *controls* the expression of , an essential homing molecule , in human T lymphocytes . Regulation FOXO1 SEPP1 17986386 1845997 In conclusion , the promoter is a target of the Akt/FoxO signal transduction cascade and SeP expression is *regulated* at the level of transcription by the forkhead box protein [FoxO1a] in human and rat hepatoma cells . Regulation FOXO1 SGK1 23786484 2838652 Our findings highlight the need for a re-evaluation of current paradigms of [FoxO] *regulation* by . Regulation FOXO1 SIRT1 20971845 2376083 The NAD dependent protein deacetylase is *involved* in the protection against oxidative stress by enhancing [FOXO-driven] Sod2 transcription . Regulation FOXO1 SIRT1 21743036 2466780 Mechanistically , *controls* acetylation status and functional activity of [FoxO1] that directly binds to the ATGL promoter and regulates ATGL gene transcription . Regulation FOXO1 SIRT1 21909281 2478508 and complex *regulation* of [DAF-16/FOXO] by is central to appropriate biological outcomes . Regulation FOXO1 SIRT1 23995837 2856088 Moreover , TH stimulated [FoxO1] recruitment to the PCK1 and G6PC gene promoters in a *dependent* manner . Regulation FOXO1 SKP2 15668399 1369628 This *effect* of requires Akt-specific phosphorylation of [FOXO1] at Ser-256 . Regulation FOXO1 SREBF1 24478438 2927953 Further investigation suggested that the expression of and FASN is *controlled* by the transcription factor [FoxO1] during HCV infection . Regulation FOXO1 STK4 24453252 2913000 Our studies have also shown that deficiency does not *affect* [Foxo1/3] cellular localization in CD4 T cells . Regulation FOXO1 TCF7L2 24463962 2918330 In cultured HepG2 cells , did not *regulate* HNF4? and [FOXO1] transcription , but did affect HNF4a protein expression . Regulation FOXO1 THPO 19465850 2091010 With the help of advances in confocal microscopy , laser scanning microscopy , and personal computer computational power over the last decade , it has become evident that signaling *plays* a role in HSC self-renewal and [AKT-forkhead box O] signaling in HSC dormancy . Regulation FOXO1 TMED7 23160481 2723194 [FoxO1] can *control* ( KIP1 ) expression in differentiated and tumor cells of the thyroid . Regulation FOXO1 TNF 23153974 2699945 Since , is *involved* in activation of transcription factor [FOXO1] along with oxidative stress mediated by neutrophils . Regulation FOXO1 TNFRSF9 23874982 2817953 As *effects* of <4-1BB> on AKT , [FOXO1] , ß-catenin and GSK-3ß showed delayed kinetics it is likely that an intervening molecule induced by 4-1BB and ERK signaling in activated T cells is responsible for these effects . Regulation FOXO1 TP53 23255113 2745708 Herein , we show that depletion of Aurora A kinase by RNA interference ( RNAi ) in hepatocellular carcinoma ( HCC ) cells upregulated [FoxO1] in a *dependent* manner , which induces cell cycle arrest . Regulation FOXO1 USP7 16964248 1627735 However , does negatively *regulate* [FOXO] transcriptional activity towards endogenous promoters . Regulation FOXO1 XBP1 23426330 2776127 *plays* a critical role in [FOXO1] degradation by recruiting FOXO1 to the 20S proteasome . Regulation FOXO1 ZGLP1 21255808 2453006 The *effects* of and/or candesartan on glucolipotoxicity induced apoptosis and the phosphorylation of insulin receptor substrate-2 (IRS-2) , protein kinase B (PKB) , and [forkhead box O1 (FoxO1)] were evaluated by using MIN6 cells and isolated mouse pancreatic islets . Regulation FOXO1 ZGLP1 22013015 2507845 We have previously shown that the forkhead transcription factor [FoxO1] is a prominent transcriptional *effector* of signaling in the ß-cell . Regulation FOXO3 CAPN8 19029949 2029371 PP2A associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is involved in mediated [FoxO] *regulation* . Regulation FOXO3 EPHB2 18204439 1863765 Taken together , our study elucidates a novel pathway in cell growth and tumorigenesis through negative *regulation* of [FOXO3a] by and MDM2 . Regulation FOXO4 CAPN8 19029949 2029388 PP2A associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is involved in mediated [FoxO] *regulation* . Regulation FOXO4 FBXO32 16870627 1593146 Using dietary restriction , we find that it impedes sarcopenia as well as the effects of aging on AKT phosphorylation , [FOXO4] phosphorylation , and and MuRF1 transcript *regulation* . Regulation FOXO6 CAPN8 19029949 2029337 PP2A associates more tightly with Akt in CAPNS1 knockout cells , indicating that PP2A is involved in mediated [FoxO] *regulation* . Regulation FOXP3 TNF 18053016 1846668 The functional insufficiency of nTreg cells in patients with allergic asthma may be related to the enhanced production of and its *effect* on the [Foxp3] expression . Regulation FOXP3 TNF 20181891 2229108 In contrast , had only a minimal *effect* on the Treg 's core transcriptional signature or on the intracellular levels of the [FOXP3] protein in Tregs . Regulation FOXQ1 HOXC13 16835220 1613007 We provide evidence that [Foxq1] is a downstream *target* for based on DNA binding studies as well as co-transfection and chromatin immunoprecipitation assays . Regulation FOXQ1 PTPRO 22126837 2542253 The findings should be replicated in independent samples , but indicate a *role* of in learning and memory , WDR72 with executive functioning , and an interaction between [FOXQ1] and SUMO1P1 for psychomotor speed . Regulation FPR1 TNF 20889801 2395370 The expression of [FPR] was increased in *response* to , LPS , scratch injury , and mitochondrial antigen treatment . Regulation FPR2 TNF 12270697 990952 We investigated the *effect* of on the expression and function of [FPR2] in mouse microglial cells , a crucial inflammatory cell type in the CNS . Regulation FSHB EPHB2 11399487 824214 is *involved* in GnRH elevation of GPalpha and LHbeta , but not in [FSHbeta] genes transcription . Regulation FSHB EPHB2 14736735 1226080 Thus , PKC , , JNK , p38 , and c-Src , but not Ca ( 2+ ) , are *involved* in GnRH induction of the ovine [FSHbeta] gene . Regulation FSHB EPHB2 15509729 1374773 Results showed that PD suppressed activational and [FSH beta] transcriptional *responses* to T . Regulation FSHB FOXO1 24065703 2857770 FOXO1 also decreases transcription from the human FSHB promoter , suggesting that *regulation* of [FSHB] transcription may be conserved between rodents and humans . Regulation FSHB FOXO1 24065703 2857780 In summary , our data demonstrate that can negatively *regulate* [Fshb] transcription and suggest that FOXO1 may relay metabolic hormonal signals to modulate gonadotropin production . Regulation FSHR TGM2 1359984 204505 Stabilization of [follicle stimulating hormone-receptor] complexes may *involve* calcium dependent activation . Regulation FST IL1B 17636213 1770720 In the present study , the *effect* of , 17-beta estradiol ( E2 ) , and progesterone ( Pr ) on activin A and [follistatin (FS)] secretion from cultured human endometrial stromal cells ( HESCs ) is evaluated . Regulation FST IL1B 9645713 514901 *regulates* pituitary [follistatin] and inhibin/activin betaB mRNA levels and attenuates FSH secretion in response to activin-A . Regulation FURIN AGR2 20705504 2363450 Our studies also indicate that [Fur] is required for the induced expression of the global regulators Agr and Rot in low iron and a number of extracellular virulence factors such as the haemolysins which are also Sae- and *regulated* . Regulation FURIN F2R 24015257 2837206 Despite no apparent direct effect on virus replication during in vitro experiments , an important *role* for in the regulation of [furin] expression in the lungs was shown for the first time . Regulation FUT1 CTGF 12065687 954660 The aim of the present study was to assess the *effects* of on rat primary [HSC] and its regulation in a well established model of in vitro liver fibrogenesis . Regulation FUT1 CTGF 12065687 954665 In conclusion , this study extends the *role* of in [HSC] activation and suggests that CTGF up-regulation might be a central pathway during HSC activation . Regulation FUT1 EPHB2 10498647 647611 In this study , we evaluated the *role* of activation in cultured [HSC] stimulated with platelet derived growth factor ( PDGF ) and after induction of liver injury in vivo . Regulation FUT1 ID1 11600477 870715 Clarification of the *role* of MyoD and proteins in [HSC] activation and liver fibrogenesis is now required . Regulation FUT1 ID1 19478045 2115702 In addition , the ability of Id1 ( -/- ) HSCs to self-renew was normal , suggesting does not *affect* [HSC] function . Regulation FUT1 MMP28 16958682 1611195 In vitro experiments also demonstrated the *role* of in activation of [HSC] cultured in 3-D ECM . Regulation FUT1 MMP7 16958682 1611210 In vitro experiments also demonstrated the *role* of in activation of [HSC] cultured in 3-D ECM . Regulation FUT4 FUT10 23986452 2851053 Our data suggest that is *involved* in a unique [a1,3-fucosyltransferase] activity with stringent substrate specificity , and that this activity is required to maintain stem cells in an undifferentiated state . Regulation FUT4 HNF1A 21203500 2359164 We show that and its downstream target HNF4a *regulate* the expression of key [fucosyltransferase] and fucose biosynthesis genes . Regulation FUT4 HNF4A 21203500 2359165 We show that HNF1a and its downstream target *regulate* the expression of key [fucosyltransferase] and fucose biosynthesis genes . Regulation FUT4 HSF1 23959823 2885300 and Sp1 *regulate* [FUT4] gene expression and cell proliferation in breast cancer cells . Regulation FUT4 KCNH4 11006292 752569 Human [alpha (1,3)-fucosyltransferase IV] ( FUTIV ) gene expression is *regulated* by in the U937 cell line . Regulation FUT4 NEU1 18953356 1989285 [CD15] expression in human myeloid cell differentiation is *regulated* by activity . Regulation FUT4 NEU2 18953356 1989286 [CD15] expression in human myeloid cell differentiation is *regulated* by activity . Regulation FUT4 NEU3 18953356 1989287 [CD15] expression in human myeloid cell differentiation is *regulated* by activity . Regulation FUT4 NEU4 18953356 1989284 [CD15] expression in human myeloid cell differentiation is *regulated* by activity . Regulation FUT4 SP1 23959823 2885299 HSF1 and *regulate* [FUT4] gene expression and cell proliferation in breast cancer cells . Regulation FZD4 WNT2 17386109 1720841 *Regulation* of norrin receptor [frizzled-4] by in colon derived cells . Regulation FZD4 WNT2 17386109 1720842 The latter interactions may be modulated via *regulation* of [Fz4] expression by . Regulation G0S2 PPARA 16086669 1481925 Hepatic expression of [G0S2] was up-regulated by fasting and by the PPARalpha agonist Wy14643 in a *dependent* manner . Regulation G6PC FOXO1 11467835 840747 Differential *regulation* of endogenous [glucose-6-phosphatase] and phosphoenolpyruvate carboxykinase gene expression by the forkhead transcription factor in H4IIE-hepatoma cells . Regulation G6PC FOXO1 11467835 840756 The insulin responsive H4IIEC3 rat hepatoma cell line ( H4 cells ) was used in order to determine the *role* of the transcription factor in the regulation of phosphoenolpyruvate carboxykinase ( PEPCK ) and [glucose-6-phosphatase (G6Pase)] . Regulation G6PC FOXO1 21804540 2462465 Conversely , Notch1 gain-of-function promotes insulin resistance in a *dependent* manner and induces [glucose-6-phosphatase] expression . Regulation G6PC FOXO1 22291689 2520633 Gene expression of PEPCK and [G6Pase] was *regulated* by the transcription factor in HCV infected cells . Regulation G6PC TNF 15167811 1280261 The *regulation* of [G6Pase] by was not mediated by activation of the phosphoinositide 3-kinase/protein kinase B pathway , extracellular-signal regulated protein kinase or p38 mitogen activated protein kinase . Regulation G6PC TNF 9160827 431814 A direct inhibitory *effect* of on [G6Pase] promoter activity was demonstrated using HuH-7 cells transiently transfected with G6Pase promoter , fused to a reporter gene . Regulation G6PD TNF 9042391 416094 These data indicate that the proinflammatory cytokine *plays* an important role in the regulation of cellular [G6PD] expression in hepatic immune competent cells . Regulation GAB1 EPHB2 11445578 850501 *regulates* the hepatocyte growth factor mediated interaction of [Gab1] and the phosphatidylinositol 3-kinase . Regulation GAB1 EPHB2 11896055 944401 negatively *regulates* the epidermal growth factor mediated interaction of [Gab1] and the phosphatidylinositol 3-kinase . Regulation GAB1 F2R 22883624 2641841 Conversely , [GAB1] overexpression , in a *dependent* manner , disrupts epithelial apical-basal polarity , promotes multilumen cyst formation , and enhances growth factor induced epithelial cell scattering . Regulation GAB1 PECAM1 20723025 2357017 To investigate the possibility that *regulates* the formation of the [Gab1-p85] signaling complexes , and the potential effect of such interactions on GPVI mediated platelet activation in platelets . Regulation GAB3 DCT 11023194 738264 Patients were assessed for immunoglobulin [G antibody (Ab)] *responses* to the melanoma associated antigens (MAA) tyrosinase , gp100 , , and MAGE-A1 by affinity enzyme linked immunosorbent assay . Regulation GAB3 MAGEA1 11023194 738265 Patients were assessed for immunoglobulin [G antibody (Ab)] *responses* to the melanoma associated antigens (MAA) tyrosinase , gp100 , TRP-2 , and by affinity enzyme linked immunosorbent assay . Regulation GAB3 PTPN11 22362894 2606213 also *plays* a central role in mediating [FGF/GAB/ERK] activity , required for epithelial repair program . Regulation GAB3 TYR 11023194 738263 Patients were assessed for immunoglobulin [G antibody (Ab)] *responses* to the melanoma associated antigens (MAA) , gp100 , TRP-2 , and MAGE-A1 by affinity enzyme linked immunosorbent assay . Regulation GABPA EPHB2 15292179 1296602 NADPH oxidase and signaling *regulates* hyperoxia induced [Nrf2-ARE] transcriptional response in pulmonary epithelial cells . Regulation GABPA EPHB2 20302373 2238034 Neurotrophic and cytoprotective action of luteolin in PC12 cells through *dependent* induction of [Nrf2-driven] HO-1 expression . Regulation GAD2 EPHB2 20739478 2401395 Dissection of the intracellular pathway that underlies this process revealed that BDNF/TrkB signaling controls the transcription of [GAD65] in a *dependent* manner . Regulation GAD2 IL1B 10433070 633919 In this study we investigated the role of the NO pathway in mediating the *effects* of on [GAD-65] and HSP-70 expression and on insulin secretion . Regulation GAD2 IL1B 8746789 343519 TGF-beta ( 40 ng/ml ) did not block the *effects* of ( 1000 pg/ml ) on HSP-70 or [GAD-65] expression . Regulation GAD2 TNF 8781713 344303 2 ) at doses of 10 , 100 , 1000 U/ml which stimulated insulin secretion had no *effect* on [GAD-65] expression . Regulation GADD45A EPHB2 21062976 2344865 GADD45ß induction was not found after treatment with either the mitogen activated protein kinase-extracellular signal regulated kinase ( ERK ) kinase ( MEK ) inhibitor U0126 or the Raf inhibitor ZM336372 , suggesting that [GADD45ß] induction by sorafenib was *independent* of signaling activity . Regulation GADD45A MAP2K6 21062976 2344871 GADD45ß induction was not found after treatment with either the mitogen activated protein kinase-extracellular signal regulated kinase ( ERK ) kinase ( MEK ) inhibitor U0126 or the Raf inhibitor ZM336372 , suggesting that [GADD45ß] induction by sorafenib was *independent* of signaling activity . Regulation GAL TLR7 20727792 2313138 Thus , we present dependent negative *regulation* of [alpha-Gal-A] as a mechanistic link between pathogen recognition and self lipid antigen induction for NKT cells . Regulation GALT TNF 17712626 1866052 Real-time PCR showed that or LPS *affected* [beta-1,4-GalT] I mRNA expression in a time- and dose dependent manner . Regulation GALT TNF 17712626 1866057 In addition , we observed that not only exogenous but also TNF-alpha produced by type-2 astrocytes *affected* [beta-1,4-GalT] I mRNA production in type-2 astrocytes . Regulation GALT TNF 17917074 1804098 TNF-alpha and TNFR2 are not detected in control astrocytes and upregulated significantly with LPS stimulation and that activation of these receptors by *affects* expressions of [beta-1,4-GalT] I and V mRNAs . Regulation GALT TNF 17917074 1804099 In addition , we observed that not only exogenous but also TNF-alpha produced by astrocytes *affected* [beta-1,4-GalT] I and V mRNAs production in astrocytes . Regulation GAP43 MAP2K6 18996496 2016044 Both antioxidants and inhibitor *affected* DHA induced [GAP-43] expression , whereas the specific PI3K inhibitor LY294002 did not . Regulation GAP43 S100B 9237519 445646 *plays* a role in neurite extension , microtubule and dendritic stabilization and regulation of the growth associated protein [GAP-43] , all of which are key elements in the production of synapses . Regulation GAPDH CCND1 10708446 673516 Consistent with this , we observe preferential downregulation of during infection and no *effect* on [GAPDH] . Regulation GAPDH EPHB2 22964641 2827271 In defining each pathway 's contributions , we found that AKT inhibition alone maximally induced GAPDH nuclear accumulation , whereas inhibition alone had no *effect* on [GAPDH] localization . Regulation GAPDH IL1B 19060282 2047439 With use of the transformed rat Müller cell line ( rMC-1 ) and isolated human Müller cells ( HMCs ) , the authors examined the *effect* of high glucose ( 25 mM ) , , TNFalpha , IL-6 , and high glucose ( 25 mM ) plus inhibitors of the caspase-1/IL-1beta signaling pathway on [GAPDH] nuclear accumulation , which was evaluated by immunofluorescence analysis . Regulation GAPDH MAP2K6 22964641 2827277 In defining each pathway 's contributions , we found that AKT inhibition alone maximally induced GAPDH nuclear accumulation , whereas inhibition alone had no *effect* on [GAPDH] localization . Regulation GAS2 CAPN8 11387205 821751 Moreover , we demonstrate that [Gas2] physically interacts with m-calpain in vivo and that recombinant Gas2 inhibits *dependent* processing of p53 . Regulation GAST EDN2 8587338 341614 *Effects* of on serum [gastrin] level and acid secretion in rats . Regulation GAST IL1B 21445336 2412250 induced Smad 7 negatively *regulates* [gastrin] expression . Regulation GAST IL1B 21445336 2412251 However , we hypothesized that *regulation* of [gastrin] by would depend on the cell 's ability to integrate inputs from multiple signaling pathways to generate appropriate biological response . Regulation GAST IL1B 24009751 2836897 In this study , the probable pathway by which induces NFkB and *affects* [gastrin] expression has been elucidated . Regulation GAST ITGB2 15004185 1217407 We conclude that M5 protein interferes with the *dependent* association between [GAS] and neutrophils , and thereby blocks subsequent ingestion of the bacteria . Regulation GATA1 TNF 18805401 1981236 Indeed the p38 inhibitor , SB203580 , abrogated the inhibitory *effect* of on the major erythroid transcription factor [GATA-1] as well as erythroid marker expression in Epo induced TF-1 cells . Regulation GATA1 TNF 19212691 2034127 We show here the inhibitory *effect* of , a proinflammatory cytokine , on hemoglobinization and erythroid transcription factor [GATA-1] expression in erythroleukemia ( HEL ) as well as in chronic myelogenous leukemia ( K562 ) cells , which were induced to differentiate towards the erythroid lineage after aclacinomycin ( Acla ) , doxorubicin ( Dox ) or hemin ( HM ) treatment . Regulation GATA3 FOXA1 20501593 2263821 Using breast cancer cell lines , we also demonstrate that *regulates* ERalpha expression , but not [GATA3] . Regulation GATA4 EPHB2 12468531 1055267 These results demonstrate that HGF protects cardiac muscle cells against apoptosis via a signaling pathway involving *dependent* phosphorylation of [GATA-4] . Regulation GATA4 MAP2K6 12468531 1055273 These results demonstrate that HGF protects cardiac muscle cells against apoptosis via a signaling pathway involving *dependent* phosphorylation of [GATA-4] . Regulation GATA6 EPHB2 18454176 1951526 Oncogenic Ras upregulates NADPH oxidase 1 gene expression through *dependent* phosphorylation of [GATA-6] . Regulation GATA6 EPHB2 18454176 1951558 On the basis of these results , we propose that oncogenic Ras signaling upregulates the transcription of Nox1 through *dependent* phosphorylation of [GATA-6] . Regulation GATA6 MAP2K6 18454176 1951532 Oncogenic Ras upregulates NADPH oxidase 1 gene expression through *dependent* phosphorylation of [GATA-6] . Regulation GATA6 MAP2K6 18454176 1951564 On the basis of these results , we propose that oncogenic Ras signaling upregulates the transcription of Nox1 through *dependent* phosphorylation of [GATA-6] . Regulation GC ANGPT1 7528305 280978 SBP and [DBP] *responses* to were also strongly related to temocapril diacid concentration ( r = -0.81 and r = -0.88 , n = 148 ) . Regulation GCG ARSA 7043491 20701 The had no significant *effect* on plasma [glucagon] or gastric inhibitory polypeptide in either group I or group II . Regulation GCG GLP1R 23649520 2827813 blockade did not *affect* ß-cell function or meal induced [glucagon] release before the operation but did impair glucose tolerance . Regulation GCG GPR115 23269670 2741578 The family C group 6 subtype A ( GPRC6A ) receptor is *involved* in amino acid induced [glucagon-like] peptide-1 secretion from GLUTag cells . Regulation GCG GPR115 23457410 2765849 It has been hypothesized that increased plasma bile acids ( BAs ) contribute to metabolic improvements after Roux-en-Y gastric bypass ( RYGB ) surgery by the TGR5 mediated *effects* on [glucagon-like] peptide-1 secretion and thyroid hormones . Regulation GCG GPR132 23269670 2741567 The family C group 6 subtype A ( GPRC6A ) receptor is *involved* in amino acid induced [glucagon-like] peptide-1 secretion from GLUTag cells . Regulation GCG GPR132 23457410 2765838 It has been hypothesized that increased plasma bile acids ( BAs ) contribute to metabolic improvements after Roux-en-Y gastric bypass ( RYGB ) surgery by the TGR5 mediated *effects* on [glucagon-like] peptide-1 secretion and thyroid hormones . Regulation GCG GPR87 23269670 2741647 The family C group 6 subtype A ( GPRC6A ) receptor is *involved* in amino acid induced [glucagon-like] peptide-1 secretion from GLUTag cells . Regulation GCG GPR87 23457410 2765919 It has been hypothesized that increased plasma bile acids ( BAs ) contribute to metabolic improvements after Roux-en-Y gastric bypass ( RYGB ) surgery by the TGR5 mediated *effects* on [glucagon-like] peptide-1 secretion and thyroid hormones . Regulation GCG IL1B 2103305 150442 Previous studies have demonstrated a stimulatory *effect* of on insulin and [glucagon] release from the perfused rat pancreas , accompanied by selective lysis of 20 % of beta-cells as assessed by electronmicroscopy . Regulation GCG TF 6877237 29752 This hormone also enhanced production and [glucagon] *response* . Regulation GCHFR CAPN8 17121855 1686413 Suppression of *dependent* cleavage of the CDK5 activator [p35] to p25 by site-specific phosphorylation . Regulation GCHFR CAPN8 17506859 1750966 We show here that endoplasmic reticulum ( ER ) stress causes the *dependent* cleavage of [p35] to p25 in primary cultured cortical neurons . Regulation GCHFR EPHB2 18438930 1932657 Thus , *dependent* [p35] up-regulation and MAPK/ERK dependent and PI3K/Akt dependent Bcl2 up-regulation contribute to BDNF stimulated neural differentiation and to the survival of differentiated cells . Regulation GCHFR TLR7 15851485 1399520 Moreover , analysis of interferon regulatory factors (IRF) regulation in moDC suggests a role for IRF7/8 in mediating IRF3 independent type I IFN and possibly [IL-12p35] synthesis in *response* to . Regulation GCK FOXO1 19740748 2158404 and HNF-4 are *involved* in regulation of hepatic [glucokinase] gene expression by resveratrol . Regulation GCK IL1B 11374865 817899 In heat shock treated islets , glucose utilization and [glucokinase] activity were not *affected* by 1.5 U/ml . Regulation GCK IL1B 9989930 597175 When the *effects* of and TNF-alpha on the gene expression of pancreatic GLUT2 and [glucokinase] were examined , the level of GLUT2 and glucokinase mRNA in pancreatic islets was significantly decreased . Regulation GCK TNF 9989930 597174 When the *effects* of IL-1beta and on the gene expression of pancreatic GLUT2 and [glucokinase] were examined , the level of GLUT2 and glucokinase mRNA in pancreatic islets was significantly decreased . Regulation GDF11 GPRASP2 24019467 2846070 *Regulation* of [GDF-11] and myostatin activity by GASP-1 and . Regulation GDF15 MAP2K6 18413810 1894225 Pretreatment with p38 kinase inhibitor blocked the VES induced increase in NAG-1 protein and mRNA levels , whereas an inhibition of protein kinase C , Akt , c-Jun NH ( 2 ) -terminal kinase , or activity had no *effect* on VES induced [NAG-1] levels . Regulation GDF15 PLAU 19540205 2136562 [Macrophage inhibitory cytokine-1 (MIC-1)] and subsequent mediate cell death *responses* by ribotoxic anisomycin in HCT-116 colon cancer cells . Regulation GDI1 RAB31 19996123 2224964 [GDI] *regulates* vesicular protein trafficking by acting on the activity of several proteins . Regulation GDI2 RAB31 19996123 2224991 [GDI] *regulates* vesicular protein trafficking by acting on the activity of several proteins . Regulation GDNF EPHB2 15193298 1259588 [GDNF] *regulates* the A beta induced endoplasmic reticulum stress response in rabbit hippocampus by inhibiting the activation of gadd 153 and the JNK and kinases . Regulation GDNF EPHB2 17210798 1709555 The extent of acute ERK activation and GDNF release were significantly correlated to each other in individual antidepressants , suggesting an important *role* of acute activation in [GDNF] production . Regulation GDNF EPHB2 17210798 1709564 Taken together , these findings indicate that activation through PTK *regulates* antidepressant induced [GDNF] production and that the GDNF production in glial cells may be a novel action of the antidepressant , which is independent of monoamine . Regulation GDNF MAP2K6 11595754 870215 These results suggested that amitriptyline induced [GDNF] synthesis and release occurred at the transcriptional level , and may be *regulated* by signalling . Regulation GDNF PLAU 9974409 596530 Using electrophoretic mobility shift and supershift assays , we then demonstrated that Stat1 is rapidly activated in endothelial cells in *response* to and [ATF] . Regulation GDNF TNF 16956589 1627643 The *role* of and its receptors in the production of NGF and [GDNF] by astrocytes . Regulation GDNF TNF 20601681 2303799 We also tested whether [GDNF] production is *regulated* by or tryptase , the products of mast cells or macrophages . Regulation GDNF TNF 20601681 2303801 and tryptase had no *effect* on the secretion of [GDNF] by HTPCs or HTPC-Fs . Regulation GEMIN2 SMN2 10767334 684914 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Regulation GEMIN4 SMN2 10767334 684934 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Regulation GEMIN4 STK39 23907667 2861540 BRSK2 ( also known as SAD-A ) , a of the AMP activated protein kinase family *affected* [VCP/p97] activity in ERAD . Regulation GEMIN5 SMN2 10767334 684944 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Regulation GFAP IL1B 10098836 601740 [Glial fibrillary acidic protein] transcription *responses* to transforming growth factor-beta1 and are mediated by a nuclear factor-1-like site in the near-upstream promoter . Regulation GFAP IL1B 19940926 2167651 Importantly , Nestin-Cre and [GFAP-Cre] rank ( floxed ) deleter mice are resistant to lipopolysaccharide induced fever as well as fever in *response* to the key inflammatory cytokines and TNFalpha . Regulation GFAP IL1B 7931319 275266 To study the *effect* of recombinant human ( rhIL-1 beta ) on astrocyte morphology , [glial fibrillary acidic protein (GFAP)] and vimentin expression , and actin organization , we conducted a systematic survey using dissociated human fetal astrocyte cultures . Regulation GFAP IL1B 8406676 233052 *Effects* of and tumor necrosis factor-alpha on the expression of [glial fibrillary acidic protein] and transferrin in cultured astrocytes . Regulation GFAP TNF 16736247 1631462 *affects* the expression of [GFAP] and S100B : implications for Alzheimer 's disease . Regulation GFAP TNF 8406676 233051 *Effects* of interleukin-1 beta and on the expression of [glial fibrillary acidic protein] and transferrin in cultured astrocytes . Regulation GFI1 IL1RL1 24141388 2868126 [Gfi1] ` preferentially ' *regulated* the responsiveness of ILC2 cells to interleukin 33 (IL-33) by directly activating , which encodes the IL-33 receptor ( ST2 ) . Regulation GH1 EDN2 10479676 643467 Expression of Ca ( 2+ ) -mobilizing ( A ) receptors and their *role* in the control of Ca ( 2+ ) influx and [growth hormone] secretion in pituitary somatotrophs . Regulation GH1 EPHB2 16109809 1474084 PKC and are differentially *involved* in gonadotropin releasing hormone induced [growth hormone] gene expression in the goldfish pituitary . Regulation GH1 IL1B 14518239 480039 Since proinflammatory cytokines mediate many of the acute responses in critical illness , we evaluated the *effects* of and TNF-alpha on [growth hormone receptor-(GHR-)mRNA] in cultured rat hepatocytes . Regulation GH1 IL1B 15266826 1276032 To investigate the *effect* ( s ) of on the activity of human [growth hormone] ( hGH ) gene promoter in rat pituitary GH3 cells and the molecular mechanism . Regulation GH1 IL1B 16043966 1459727 Stimulatory *effect* of on [growth hormone] gene expression and growth hormone release from rat GH3 cells . Regulation GH1 IL1B 19180878 2007103 *Effect* of on [growth hormone] gene expression and its possible molecular mechanism in rat MtT/S somatotroph cells . Regulation GH1 IL1B 19180878 2007104 To elucidate the *effect* of on human [growth hormone] ( hGH ) gene expression in a rat somatotropic pituitary cell line MtT/S . Regulation GH1 TNF 14518239 480038 Since proinflammatory cytokines mediate many of the acute responses in critical illness , we evaluated the *effects* of IL-1 beta and on [growth hormone receptor-(GHR-)mRNA] in cultured rat hepatocytes . Regulation GH1 TNF 1653958 164732 *affects* [growth hormone] secretion by a direct pituitary interaction . Regulation GH1 TNF 18719026 1984921 Nuclear factor-kappaB mediates the inhibitory *effects* of on [growth hormone-inducible] gene expression in liver . Regulation GH1 TNF 7479297 331850 We examined the chronic ( 72 h ) *effects* of 30 ng/ml recombinant murine on release of immunoreactive [growth hormone (GH)] , prolactin (PRL) , thyrotropin ( TSH ) , and TSH glycosylation , as assessed by lectin binding , in cultured rat anterior pituitary cells . Regulation GHR IL1B 9025720 405828 As many of the acute inflammatory responses in critical illness are mediated by the proinflammatory cytokines interleukin 1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha) , the present studies evaluated and TNF-alpha *effects* on steady-state and GH-stimulated IGF-I synthesis and [GH receptor] mRNA levels . Regulation GHR TNF 9025720 405827 As many of the acute inflammatory responses in critical illness are mediated by the proinflammatory cytokines interleukin 1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha) , the present studies evaluated IL-1 beta and *effects* on steady-state and GH-stimulated IGF-I synthesis and [GH receptor] mRNA levels . Regulation GHR TNF 9048612 416827 Neither nor IL-6 *affected* the [GHR/GHBP] gene expression . Regulation GIP ARSA 7043491 20702 The had no significant *effect* on plasma glucagon or [gastric inhibitory polypeptide] in either group I or group II . Regulation GJA1 CTGF 20117462 2202367 Rac1 induced *regulates* [connexin 43] and N-cadherin expression in atrial fibrillation . Regulation GJA1 EPHB2 21575204 2441437 AGE-BSA down-regulated [Cx43] expression in HAEC , mainly through reduced Cx43 transcription , and the process *involved* activation of and p38 MAPK . Regulation GJA1 EPHB2 23712704 2806464 Subsequently , extracellular signal regulated kinase ( ERK ) was inhibited with PD98059 to analyze the *role* of in modulating [CX43] expression after LPS preconditioning . Regulation GJA1 F2R 21147226 2396188 In turn , the , PAR-1 , *regulates* the expression of the gap junction protein [Connexin-43] and the tumor suppressor gene Maspin . Regulation GJA1 MMP7 16769909 1576712 *affects* [connexin-43] levels , electrical conduction , and survival after myocardial infarction . Regulation GJA1 TNF 12538692 1050254 In this work , the *effects* of bacterial LPS , , and IFN-gamma on gap junctional communication ( dye coupling ) and on the expression of [connexin43] ( immunofluorescence , immunoblotting , and RT-PCR ) in monocytes/macrophages were studied . Regulation GJA1 TNF 17872368 1823589 did not *affect* total cell [Cx43-PP2A] catalytic subunit interaction , but it did induce PP2A catalytic subunit recruitment to the Triton X-100 insoluble subcellular fraction , in which Cx43-gap junction plaques are recovered . Regulation GJA1 TNF 18297686 1911982 Using pharmacological inhibitors of the NFkappaB signaling pathway , we determined that the NFkappaB signaling cascade is not implicated in *effect* on [Cx43] expression and in the subsequent decrease of GJIC . Regulation GJA1 TNF 18297686 1911983 Conversely , in NFkappaB essential modulator ( NEMO ( - ) ) fibroblasts , lack of NFkappaB activation did not influence both the *effect* of on [Cx43] expression and on GJIC . Regulation GJA1 TNF 21674053 2442909 Therefore , we investigate the *effect* of interleukin (IL) 4 , IL6 , IL10 , ( TNFa ) and transforming growth factor-beta1 ( TGFß1 ) on GJIC , and [Cx43] and Cx45 expression in cultured human bladder smooth muscle cells ( hBSMC ) and human suburothelial myofibroblasts ( hsMF ) . Regulation GJA1 TNF 23768164 2820211 The inhibitory *effects* of on [Cx43] expression and GJIC in human corneal fibroblasts are mediated , at least in part , by the JNK signaling pathway , which therefore likely plays a role in corneal inflammation . Regulation GJB1 IL1B 15350541 1292419 *regulates* expression of [Cx32] , occludin , and claudin-2 of rat hepatocytes via distinct signal transduction pathways . Regulation GJB2 GCG 7593318 330434 Induction and *regulation* of [connexin26] by in primary cultures of adult rat hepatocytes . Regulation GJB2 GJB6 22098503 2514230 Our results support earlier observations on the interdependency of Cx30/Cx32 targeting to A/O gap junctions and further suggest that [Cx26] mRNA expression is *affected* by gene expression . Regulation GJB2 MAPK8IP1 12064607 895201 [Connexin26] is *regulated* in rat urothelium by the scaffold protein . Regulation GJB2 PRDX2 16531468 1561752 increased Cx32 protein levels and *affected* negatively the [Cx26] protein levels . Regulation GJB2 SP1 9849966 554178 We had previously demonstrated that both and Sp3 transcription factors *play* a functional role in [Cx26] expression . Regulation GJB2 VDR 18259074 1919223 Expression of [connexin 26] , KCNJ10 , and transient receptor potential channel vanilloid subfamily 4/6 was not *affected* by KO-mediated hearing loss . Regulation GJC1 EPHB2 15843167 1398345 Thus , *dependent* downregulation of [GJC] upon exposure to quinones may occur both by direct phosphorylation of Cx43 and in a phosphorylation independent manner . Regulation GJC1 IL1B 15048855 1225179 Altogether , these results demonstrate that p38/SAPK2 is a central mediator of and sorbitol inhibitory *actions* on [GJC] and establish PKC among the distal effectors of p38/SAPK2 . Regulation GJC1 TNF 21674053 2442913 Therefore , we investigate the *effect* of interleukin (IL) 4 , IL6 , IL10 , ( TNFa ) and transforming growth factor-beta1 ( TGFß1 ) on GJIC , and Cx43 and [Cx45] expression in cultured human bladder smooth muscle cells ( hBSMC ) and human suburothelial myofibroblasts ( hsMF ) . Regulation GJC2 EPHB2 15843167 1398343 Thus , *dependent* downregulation of [GJC] upon exposure to quinones may occur both by direct phosphorylation of Cx43 and in a phosphorylation independent manner . Regulation GJC2 IL1B 15048855 1225177 Altogether , these results demonstrate that p38/SAPK2 is a central mediator of and sorbitol inhibitory *actions* on [GJC] and establish PKC among the distal effectors of p38/SAPK2 . Regulation GJC3 EPHB2 15843167 1398344 Thus , *dependent* downregulation of [GJC] upon exposure to quinones may occur both by direct phosphorylation of Cx43 and in a phosphorylation independent manner . Regulation GJC3 IL1B 15048855 1225178 Altogether , these results demonstrate that p38/SAPK2 is a central mediator of and sorbitol inhibitory *actions* on [GJC] and establish PKC among the distal effectors of p38/SAPK2 . Regulation GLI1 MAP2K6 17392427 1721010 Finally , we provide evidence that endogenous and AKT signaling *regulate* the nuclear localization and transcriptional activity of [GLI1] in melanoma and other cancer cells . Regulation GLP1R APOB 23806684 2815664 The inhibitory *effect* of on [GLP-1R] expression was reversed with anti-LOX-1 antibody treatment , while the inhibitory effect of liraglutide and NVPDPP728 on ROS generation was attenuated when cells were transfected with LOX-1 cDNA . Regulation GLP1R CAV1 24269940 2893108 Moreover , signaling was *involved* in PPARß/d regulated [GLP-1R] expression . Regulation GLP1R GCG 8814299 383543 Expression of [glucagon-like peptide 1 receptor] in a murine C cell line : *regulation* of calcitonin gene by peptide 1 . Regulation GLP1R INS 19008308 2035019 In conclusion , these results show that the endogenous [Glp1r] *regulates* hepatic and muscle glucose flux independent of its ability to enhance secretion . Regulation GLP1R INS 24326362 2894892 [Glucagon-like peptide 1 receptor] would be a diagnostic marker of insulinoma and might become a molecular *target* for treatment of metastatic PNETs and hormonal regulation of . Regulation GLP1R LEP 18078857 1847215 These findings suggest that the stimulating *effect* of on [GLP-1R] expression , with no changes in NPY induced activity , could enhance the anorexic actions generated through this receptor . Regulation GLP1R OLR1 23806684 2815663 To further prove that *plays* a pivotal role in ROS and [GLP-1R] expression , we treated VSMCs with LOX-1 antibody or transfected cells with human LOX-1 cDNA . Regulation GLP1R SP1 9927286 588493 Gene expression of the human [glucagon-like peptide-1 receptor] is *regulated* by and Sp3 . Regulation GLP1R SP3 9927286 588494 Gene expression of the human [glucagon-like peptide-1 receptor] is *regulated* by Sp1 and . Regulation GLP1R SREBF1 24269940 2893107 Moreover , signaling was *involved* in PPARß/d regulated [GLP-1R] expression . Regulation GLP1R ZGLP1 20805279 2313829 Common genetic variation in [GLP1R] and insulin secretion in *response* to exogenous in nondiabetic subjects : a pilot study . Regulation GLP1R ZGLP1 20824235 2318720 This difference may result from the pharmacologic levels of GLP-1 activity that are achieved with the agonists and their direct *action* on the [GLP-1 receptor] . Regulation GLS EPHB2 22538822 2596025 Structural basis for the allosteric inhibitory mechanism of human kidney-type [glutaminase] ( KGA ) and its *regulation* by signaling in cancer cell metabolism . Regulation GLS MAP2K6 22538822 2596031 Structural basis for the allosteric inhibitory mechanism of human kidney-type [glutaminase] ( KGA ) and its *regulation* by signaling in cancer cell metabolism . Regulation GLUL IL1B 18001575 1827113 [ *Effect* of on [glutamine synthetase] in rat retinal Müller cell under high glucose conditions ] . Regulation GLUL IL1B 18001575 1827114 To investigate the *effect* of cytokine on the [glutamine synthetase (GS)] in retinal Müller cell under high glucose conditions and its possible mechanism . Regulation GLUL IL1B 19839866 2155208 *Role* of on the [glutamine synthetase] in retinal Müller cells under high glucose conditions . Regulation GLUL IL1B 19839866 2155209 To investigate ( 1 ) the *role* of cytokine on the [glutamine synthetase] in retinal Müller cells under high glucose condition , ( 2 ) the mechanism for down-regulation of glutamine synthetase in retinal Müller cells induced by interleukin-1beta under high glucose conditions . Regulation GLUL IL1B 19839866 2155210 The *effect* of on the expression of [glutamine synthetase] and c-Jun in retinal Müller cells under normal and high glucose conditions was measured by immunocytochemistry , Western blot , and real-time ( RT ) PCR , and was further confirmed by c-Jun siRNA method . Regulation GLUL TNF 9652396 515849 Transcriptional *regulation* of the rat [glutamine synthetase] gene by . Regulation GNA12 RGS16 14634662 1170956 RGS4 does not bind G alpha 13 or attenuate G alpha 13-dependent responses , and neither nor RGS4 *affects* [G alpha 12-mediated] signalling . Regulation GNA13 RGS16 14634662 1170958 RGS4 does not bind G alpha 13 or attenuate [G alpha 13-dependent] responses , and neither nor RGS4 *affects* G alpha 12-mediated signalling . Regulation GNA14 TNF 23975421 2942263 Moreover , the microarray analysis and colony formation assay indicated that NADPH oxidase organizer 1 (Noxo1) and [Gna14] are induced in tumor epithelial cells in a *dependent* manner , and have an important role in tumorigenicity and tumor initiating cell property of gastric cancer cells . Regulation GNAT1 RGS16 9211888 441944 Our data suggest that *effects* of on [transducin] 's GTPase activity are attenuated by Pgamma but independent of a putative membrane GTPase activating protein factor . Regulation GNB1 RGS16 9211888 441945 Our data suggest that *effects* of on [transducin] 's GTPase activity are attenuated by Pgamma but independent of a putative membrane GTPase activating protein factor . Regulation GNB2L1 IL1B 9298128 453278 Neither , nor IGF had an *effect* on PKC or [RACK1] expression . Regulation GNGT1 RGS16 9211888 441946 Our data suggest that *effects* of on [transducin] 's GTPase activity are attenuated by Pgamma but independent of a putative membrane GTPase activating protein factor . Regulation GNGT2 RGS16 9211888 441947 Our data suggest that *effects* of on [transducin] 's GTPase activity are attenuated by Pgamma but independent of a putative membrane GTPase activating protein factor . Regulation GNRH1 EPHB2 11591707 883120 Egr-1/MGRE binding was induced by [GnRH] in an *dependent* manner . Regulation GNRH1 EPHB2 11861527 917310 We conclude that and JNK are *involved* in basal and [GnRH-A] stimulation of LHbeta-CAT activity . Regulation GNRH1 EPHB2 12138087 991523 Like Ark , a constitutively active mutant of Rac suppressed [GnRH] transcription in an *dependent* manner . Regulation GNRH1 EPHB2 12538624 1050202 Thus , and c-Src but not JNK are *involved* in basal and [GnRH-A-stimulated-alphaCAT] , whereas c-Src contribution is independent of ERK activation . Regulation GNRH1 EPHB2 14736735 1226083 Thus , PKC , , JNK , p38 , and c-Src , but not Ca ( 2+ ) , are *involved* in [GnRH] induction of the ovine FSHbeta gene . Regulation GNRH1 EPHB2 23880664 2849570 Moreover , kisspeptin stimulated MAPKs and AKT signaling , and signaling was functionally *involved* in the kisspeptin induced [GnRH] expression . Regulation GNRH1 GPR115 23321696 2733297 Because the cognate GnRH receptor is a G protein coupled receptor , we examined whether [GnRH-] ( 1-5 ) *regulates* migration by also activating a . Regulation GNRH1 GPR132 23321696 2733286 Because the cognate GnRH receptor is a G protein coupled receptor , we examined whether [GnRH-] ( 1-5 ) *regulates* migration by also activating a . Regulation GNRH1 GPR87 23321696 2733366 Because the cognate GnRH receptor is a G protein coupled receptor , we examined whether [GnRH-] ( 1-5 ) *regulates* migration by also activating a . Regulation GNRH1 IL1B 11464578 839437 The quantitative level of [GnRH] mRNA expression *regulated* by in Vero cells was determined by quantitative competitive PCR ( QC PCR ) with standard curve methodology . Regulation GNRH1 IL1B 12568852 1057184 To investigate the *role* of in regulating [GnRH] mRNA expression in cultured human endometrial stromal cells using a modified semiquantitative competitive reverse transcription and polymerase chain reaction ( PCR ) . Regulation GNRH1 IL1B 12568852 1057186 mediated *regulation* of stromal cell [GnRH] mRNA expression was determined by quantitative competitive PCR . Regulation GNRH1 IL1B 14990538 1220394 Transient hypogonadotrophic hypogonadism in males with acute toxoplasmosis : suppressive *effect* of on the secretion of [GnRH] . Regulation GNRH1 MSX1 15743757 1403130 These findings strongly support a *role* for and DLX in contributing to spatiotemporal regulation of [GnRH] transcription during development . Regulation GNRH1 TNF 11207945 787138 We examined the *effects* of and IL-6 on [LHRH] release from hypothalamic explants harvested from proestrus female and male rats in vitro . Regulation GNRHR IL1B 10792581 689318 *Effect* of on gonadotropin releasing hormone (GnRH) and [GnRH receptor] gene expression in castrated male rats . Regulation GP1BA CAPN8 20060803 2212014 The *role* of in the regulation of ADAM17 dependent [GPIbalpha] ectodomain shedding . Regulation GP1BA CAPN8 20060803 2212030 Therefore , these data indicate that *plays* an important role in the regulation of ADAM17 dependent [GPIbalpha] ectodomain shedding in both platelets and nucleated cells . Regulation GP1BA PECAM1 12893757 1157314 negatively *regulates* [GPIb/V/IX] signaling in murine platelets . Regulation GP1BB PECAM1 12893757 1157315 negatively *regulates* [GPIb/V/IX] signaling in murine platelets . Regulation GP2 EDN2 1311519 178840 *regulation* of mucus [glycoprotein] secretion from feline tracheal submucosal glands . Regulation GP2 FAS 9070496 419223 MoAb did not *affect* the intracellular accumulation of doxorubicin , the expression of [P-glycoprotein] , or the expression of the antioxidant glutathione S-transferase-pi mRNA . Regulation GP2 ITGB2 3539226 69237 Polymorphic [glycoprotein-1] on mouse platelets : possible *role* of Pgp-1 and in antibody dependent platelet cytotoxicity involving complement . Regulation GP2 TNF 15124210 1242448 *Effect* of and interferon-gamma on intestinal [P-glycoprotein] expression , activity , and localization in Caco-2 cells . Regulation GP2 TNF 15659313 1364881 *Role* of in down-regulation of hepatic cytochrome P450 and [P-glycoprotein] by endotoxin . Regulation GP2 TNF 15659313 1364893 We investigated the *role* of in the down-regulation of hepatic [P-glycoprotein] and cytochrome P450 ( CYP ) by endotoxin , using TNF-alpha gene-deficient (TNF-alpha-/-) mice . Regulation GP2 TNF 15659313 1364897 These results suggest that *plays* a pivotal role in the down-regulation of [P-glycoprotein] by endotoxin . Regulation GP2 TNF 15659313 1364903 These findings suggest that *plays* a key role in endotoxin induced down-regulation of hepatic [P-glycoprotein] , as well as plays a protective role in the regulation of hepatic CYP3A2 and CYP2C11 against endotoxin induced acute inflammatory response . Regulation GP2 TNF 17982267 1821207 We used microarray , real time RT-PCR , Western blotting , and uptake of vinblastine by RBE4 cerebral endothelial cells to test the *effects* of on the expression and functions of [P-glycoprotein] ( MDR1 ) . Regulation GP2 TNF 20300455 2224060 *Regulation* of [P-glycoprotein] in renal proximal tubule epithelial cells by LPS and . Regulation GP2 TNF 7907642 250433 Furthermore , recombinant had no *effect* on the induction of P [glycoprotein] expression in U1 cells . Regulation GP2 TNF 8968260 402582 To test the hypothesis that after cecal ligation and puncture in the rat , there is increased expression of the *dependent* , acute-phase reactant alpha 1-acid [glycoprotein] in the liver , and that this change correlates temporally with increased abundance of TNF-alpha in the hepatic parenchyma but not with circulating concentrations of TNF-alpha . Regulation GP5 EDN2 1311519 178843 *regulation* of mucus [glycoprotein] secretion from feline tracheal submucosal glands . Regulation GP5 FAS 9070496 419224 MoAb did not *affect* the intracellular accumulation of doxorubicin , the expression of [P-glycoprotein] , or the expression of the antioxidant glutathione S-transferase-pi mRNA . Regulation GP5 ITGB2 3539226 69239 Polymorphic [glycoprotein-1] on mouse platelets : possible *role* of Pgp-1 and in antibody dependent platelet cytotoxicity involving complement . Regulation GP5 TNF 15124210 1242450 *Effect* of and interferon-gamma on intestinal [P-glycoprotein] expression , activity , and localization in Caco-2 cells . Regulation GP5 TNF 15659313 1364882 *Role* of in down-regulation of hepatic cytochrome P450 and [P-glycoprotein] by endotoxin . Regulation GP5 TNF 15659313 1364894 We investigated the *role* of in the down-regulation of hepatic [P-glycoprotein] and cytochrome P450 ( CYP ) by endotoxin , using TNF-alpha gene-deficient (TNF-alpha-/-) mice . Regulation GP5 TNF 15659313 1364898 These results suggest that *plays* a pivotal role in the down-regulation of [P-glycoprotein] by endotoxin . Regulation GP5 TNF 15659313 1364904 These findings suggest that *plays* a key role in endotoxin induced down-regulation of hepatic [P-glycoprotein] , as well as plays a protective role in the regulation of hepatic CYP3A2 and CYP2C11 against endotoxin induced acute inflammatory response . Regulation GP5 TNF 17982267 1821208 We used microarray , real time RT-PCR , Western blotting , and uptake of vinblastine by RBE4 cerebral endothelial cells to test the *effects* of on the expression and functions of [P-glycoprotein] ( MDR1 ) . Regulation GP5 TNF 20300455 2224061 *Regulation* of [P-glycoprotein] in renal proximal tubule epithelial cells by LPS and . Regulation GP5 TNF 7907642 250434 Furthermore , recombinant had no *effect* on the induction of P [glycoprotein] expression in U1 cells . Regulation GP5 TNF 8968260 402610 To test the hypothesis that after cecal ligation and puncture in the rat , there is increased expression of the *dependent* , acute-phase reactant alpha 1-acid [glycoprotein] in the liver , and that this change correlates temporally with increased abundance of TNF-alpha in the hepatic parenchyma but not with circulating concentrations of TNF-alpha . Regulation GP6 EDN2 1311519 178837 *regulation* of mucus [glycoprotein] secretion from feline tracheal submucosal glands . Regulation GP6 FAS 9070496 419222 MoAb did not *affect* the intracellular accumulation of doxorubicin , the expression of [P-glycoprotein] , or the expression of the antioxidant glutathione S-transferase-pi mRNA . Regulation GP6 ITGB2 3539226 69235 Polymorphic [glycoprotein-1] on mouse platelets : possible *role* of Pgp-1 and in antibody dependent platelet cytotoxicity involving complement . Regulation GP6 TNF 15124210 1242446 *Effect* of and interferon-gamma on intestinal [P-glycoprotein] expression , activity , and localization in Caco-2 cells . Regulation GP6 TNF 15659313 1364880 *Role* of in down-regulation of hepatic cytochrome P450 and [P-glycoprotein] by endotoxin . Regulation GP6 TNF 15659313 1364892 We investigated the *role* of in the down-regulation of hepatic [P-glycoprotein] and cytochrome P450 ( CYP ) by endotoxin , using TNF-alpha gene-deficient (TNF-alpha-/-) mice . Regulation GP6 TNF 15659313 1364896 These results suggest that *plays* a pivotal role in the down-regulation of [P-glycoprotein] by endotoxin . Regulation GP6 TNF 15659313 1364900 These findings suggest that *plays* a key role in endotoxin induced down-regulation of hepatic [P-glycoprotein] , as well as plays a protective role in the regulation of hepatic CYP3A2 and CYP2C11 against endotoxin induced acute inflammatory response . Regulation GP6 TNF 17982267 1821206 We used microarray , real time RT-PCR , Western blotting , and uptake of vinblastine by RBE4 cerebral endothelial cells to test the *effects* of on the expression and functions of [P-glycoprotein] ( MDR1 ) . Regulation GP6 TNF 20300455 2224059 *Regulation* of [P-glycoprotein] in renal proximal tubule epithelial cells by LPS and . Regulation GP6 TNF 7907642 250432 Furthermore , recombinant had no *effect* on the induction of P [glycoprotein] expression in U1 cells . Regulation GP6 TNF 8968260 402554 To test the hypothesis that after cecal ligation and puncture in the rat , there is increased expression of the *dependent* , acute-phase reactant alpha 1-acid [glycoprotein] in the liver , and that this change correlates temporally with increased abundance of TNF-alpha in the hepatic parenchyma but not with circulating concentrations of TNF-alpha . Regulation GP9 EDN2 1311519 178846 *regulation* of mucus [glycoprotein] secretion from feline tracheal submucosal glands . Regulation GP9 FAS 9070496 419225 MoAb did not *affect* the intracellular accumulation of doxorubicin , the expression of [P-glycoprotein] , or the expression of the antioxidant glutathione S-transferase-pi mRNA . Regulation GP9 ITGB2 3539226 69241 Polymorphic [glycoprotein-1] on mouse platelets : possible *role* of Pgp-1 and in antibody dependent platelet cytotoxicity involving complement . Regulation GP9 TNF 15124210 1242452 *Effect* of and interferon-gamma on intestinal [P-glycoprotein] expression , activity , and localization in Caco-2 cells . Regulation GP9 TNF 15659313 1364883 *Role* of in down-regulation of hepatic cytochrome P450 and [P-glycoprotein] by endotoxin . Regulation GP9 TNF 15659313 1364895 We investigated the *role* of in the down-regulation of hepatic [P-glycoprotein] and cytochrome P450 ( CYP ) by endotoxin , using TNF-alpha gene-deficient (TNF-alpha-/-) mice . Regulation GP9 TNF 15659313 1364899 These results suggest that *plays* a pivotal role in the down-regulation of [P-glycoprotein] by endotoxin . Regulation GP9 TNF 15659313 1364905 These findings suggest that *plays* a key role in endotoxin induced down-regulation of hepatic [P-glycoprotein] , as well as plays a protective role in the regulation of hepatic CYP3A2 and CYP2C11 against endotoxin induced acute inflammatory response . Regulation GP9 TNF 17982267 1821209 We used microarray , real time RT-PCR , Western blotting , and uptake of vinblastine by RBE4 cerebral endothelial cells to test the *effects* of on the expression and functions of [P-glycoprotein] ( MDR1 ) . Regulation GP9 TNF 20300455 2224062 *Regulation* of [P-glycoprotein] in renal proximal tubule epithelial cells by LPS and . Regulation GP9 TNF 7907642 250435 Furthermore , recombinant had no *effect* on the induction of P [glycoprotein] expression in U1 cells . Regulation GP9 TNF 8968260 402638 To test the hypothesis that after cecal ligation and puncture in the rat , there is increased expression of the *dependent* , acute-phase reactant alpha 1-acid [glycoprotein] in the liver , and that this change correlates temporally with increased abundance of TNF-alpha in the hepatic parenchyma but not with circulating concentrations of TNF-alpha . Regulation GPER1 EPHB2 12027886 947442 The regulation of [GPR30] was *independent* of pathway activation , but the p38 pathway inhibitor induced GPR30 expression , which suggested a potential gene regulation pathway . Regulation GPHB5 IL1B 19095738 2060626 Because NF-kappaB is known to associate with acute phase inflammatory cytokines , we examined whether TNFalpha or could *regulate* [GPB5] . Regulation GPHB5 TNF 19095738 2060625 Because NF-kappaB is known to associate with acute phase inflammatory cytokines , we examined whether or IL-1beta could *regulate* [GPB5] . Regulation GPHN CAPN8 23408424 2764618 We unravel novel mechanisms for activity- and ERK dependent *action* on [gephyrin] , which are likely relevant in the context of cellular signaling affecting GABAergic transmission and homeostatic synaptic plasticity in pathology . Regulation GPI ALOX5 1409767 201422 The *effects* of a <5-lipoxygenase> inhibitor , AA-861 , on [PGI2-like] substance production in guinea-pig lungs . Regulation GPI ARSA 17259075 1691229 We assessed the *effect* of on the myocardial production of 15-epi-LXA4 and [PGI] ( 2 ) after induction by lipopolysaccharide (LPS) or PIO+ATV . Regulation GPI ARSA 2244178 145847 Conclusions on the *effect* of on the [PGI2/TxA2-balance] are hampered by uncertainties concerning the measurement PGI2 and TxA2 productions in vivo . Regulation GPI CA12 8336425 223921 A inhibitor , acetazolamide ( 100 microM ) had no clear *effect* on [pHi] in both normal and Cl ( - ) -deficient solutions . Regulation GPI EDN2 1292682 207799 The treatments of VSMC with H-7 and staurosporine ( PK-C ) inhibitors prevented the [pHi] *response* to and PMA . Regulation GPI EDN2 1811280 177293 These results not only suggest that there exists a much greater reservoir of vascular PGI2 synthesis in SHR , but also imply that the enhanced release of [PGI2] in *response* to , the most potent vasoconstrictor known , may function as a factor or a modulator to attenuate endothelin induced vasoconstriction in senescent SHR . Regulation GPI EDN2 7778066 309343 In order to determine whether this effect is mediated via protein kinase C and Na ( + ) -H+ linked pathways , the effects of staurosporine and calphostin C ( protein kinase C inhibitors ) and 5- ( N , N-hexamethylene ) amiloride ( Na ( + ) -H+ exchange blocker ) on induced [pHi] *responses* in human platelets were assessed . Regulation GPI IL1B 10207535 606836 When the cells were treated simultaneously with benzydamine and the cytokines IL-1 beta or TNF alpha , the agent benzydamine reduced ( P < 0.05 ) the stimulatory *effect* of and TNF alpha respectively , on PGE2 and [PGI2] production in human gingival fibroblasts . Regulation GPI IL1B 2025252 157282 Bradykinin ( BK ; 10 nmol/l ) synergistically potentiated the *effect* of IL-1 alpha ( 10 pg/ml ) and ( 5 pg/ml ) both on 45Ca release and on biosynthesis of PGE2 and [PGI2] . Regulation GPI IL1B 8915021 395755 When gingival fibroblasts were treated simultaneously with triclosan and IL-1beta , the stimulatory *effect* of on prostaglandin E2 ( PGE2 ) and [PGI2] formation was reduced in a dose dependent manner by triclosan . Regulation GPI LBP 1281827 205733 Neither LPS nor LPS and *affected* [pHi] or [ Cai++ ] in alveolar macrophages . Regulation GPI SLC9A2 11447025 835471 We conclude that in rabbit gastric epithelium , NHE1 and NHE4 regulate cell volume and NHE1 and *regulate* [pH(i)] . Regulation GPI SLC9A2 12474076 1023516 The results obtained strongly suggest that NHE-1 and NHE-2 are expressed in the basolateral membrane but that they have different roles : NHE-1 is responsible for pHi recovery after an acid load and is mainly *involved* in steady-state [pHi] and cell volume regulation . Regulation GPI TNF 10207535 606835 When the cells were treated simultaneously with benzydamine and the cytokines IL-1 beta or TNF alpha , the agent benzydamine reduced ( P < 0.05 ) the stimulatory *effect* of IL-1 beta and respectively , on PGE2 and [PGI2] production in human gingival fibroblasts . Regulation GPI TNF 11305695 803796 We , therefore , examined the *effects* of on Ang II-induced increases in [PGI2] production in vascular smooth muscle cells ( VSMC ) . Regulation GPI TNF 1915557 168204 M [phi] NO2- production in *response* to rIFN-gamma and either exogenous or Leishmania was strongly enhanced by prostaglandin E2 , consistent with such a mechanism . Regulation GPI TNF 2137848 128810 The difference in the M [phi] subset 's *response* remained even after the FcRI- M phi subset received a 2.5-fold increase in stimulation with the classical M phi induction regimen of IFN gamma plus bacterial cell wall product . Regulation GPI TNF 7815559 292855 We conclude that ( i ) M phi activation is a prominent part of inflammatory responses to herpesvirus infection and ( ii ) IFN gamma and *play* a critical role in both virus induced M [phi] activation and control of herpesvirus growth independent of T and B cells . Regulation GPI TNF 7815559 292859 As the M phi may be involved in MCMV latency , IFN gamma- and *dependent* M [phi] activation during primary infection may be relevant to establishment of viral latency . Regulation GPNMB MITF 24789918 2956129 Lysosomal stress in obese adipose tissue macrophages contributes to *dependent* [Gpnmb] induction . Regulation GPNMB TCF12 18313864 1891808 Microphthalmia *regulates* the expression of the novel osteoclast factor [GPNMB] . Regulation GPNMB TCF15 18313864 1891809 Microphthalmia *regulates* the expression of the novel osteoclast factor [GPNMB] . Regulation GPNMB TCF19 18313864 1891810 Microphthalmia *regulates* the expression of the novel osteoclast factor [GPNMB] . Regulation GPNMB TCF20 18313864 1891811 Microphthalmia *regulates* the expression of the novel osteoclast factor [GPNMB] . Regulation GPNMB TCF21 18313864 1891812 Microphthalmia *regulates* the expression of the novel osteoclast factor [GPNMB] . Regulation GPNMB TCF23 18313864 1891816 Microphthalmia *regulates* the expression of the novel osteoclast factor [GPNMB] . Regulation GPNMB TCF24 18313864 1891818 Microphthalmia *regulates* the expression of the novel osteoclast factor [GPNMB] . Regulation GPNMB TCF25 18313864 1891817 Microphthalmia *regulates* the expression of the novel osteoclast factor [GPNMB] . Regulation GPNMB TCF3 18313864 1891813 Microphthalmia *regulates* the expression of the novel osteoclast factor [GPNMB] . Regulation GPNMB TCF4 18313864 1891814 Microphthalmia *regulates* the expression of the novel osteoclast factor [GPNMB] . Regulation GPNMB TCF7 18313864 1891815 Microphthalmia *regulates* the expression of the novel osteoclast factor [GPNMB] . Regulation GPR1 IL1B 11704539 879205 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR1 RGS2 15292363 1278810 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR1 RGS2 19427970 2076953 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR1 TNF 11704539 879204 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR101 IL1B 11704539 879117 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR101 RGS2 15292363 1278766 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR101 RGS2 19427970 2076909 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR101 TNF 11704539 879116 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR107 IL1B 11704539 879127 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR107 RGS2 15292363 1278771 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR107 RGS2 19427970 2076914 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR107 TNF 11704539 879126 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR108 IL1B 11704539 879125 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR108 RGS2 15292363 1278770 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR108 RGS2 19427970 2076913 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR108 TNF 11704539 879124 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR110 IL1B 11704539 879137 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR110 RGS2 15292363 1278776 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR110 RGS2 19427970 2076919 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR110 TNF 11704539 879136 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR111 IL1B 11704539 879139 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR111 RGS2 15292363 1278777 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR111 RGS2 19427970 2076920 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR111 TNF 11704539 879138 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR112 IL1B 11704539 879141 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR112 RGS2 15292363 1278778 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR112 RGS2 19427970 2076921 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR112 TNF 11704539 879140 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR113 IL1B 11704539 879135 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR113 RGS2 15292363 1278775 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR113 RGS2 19427970 2076918 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR113 TNF 11704539 879134 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR114 IL1B 11704539 879143 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR114 RGS2 15292363 1278779 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR114 RGS2 19427970 2076922 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR114 TNF 11704539 879142 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR115 ADCY6 10779394 687338 We investigated the *effect* of adenovirally mediated overexpression of , a major form of AC expressed in mammalian heart , on [G protein coupled receptor] regulation of cAMP production in neonatal rat ventricular myocytes . Regulation GPR115 ADRBK1 16339447 1491469 ( GRK2 ) *plays* a key role in the desensitization of [G protein coupled receptor] signaling by phosphorylating activated heptahelical receptors and by sequestering heterotrimeric G proteins . Regulation GPR115 ADRBK1 16725308 1624761 ( GRK2 ) *plays* a key role in the modulation of [G-protein-coupled-receptor (GPCR)] signaling by both phosphorylating agonist occupied GPCRs and by directly binding to activated Galphaq subunits , inhibiting downstream effectors activation . Regulation GPR115 ADRBK1 19815545 2164381 Our results suggest a novel mechanism by which negatively *regulates* [G protein coupled receptor] signaling in a manner that is independent of receptor phosphorylation . Regulation GPR115 ADRBK1 20080565 2205795 ( GRK2 ) *plays* a central role in [G protein coupled receptor] regulation . Regulation GPR115 ANXA1 15955733 1427872 In addition , aspirin triggered epi-lipoxins and glucocorticoid regulated might *act* on the same [G-protein coupled receptor] , thus rendering this shared receptor a more likely and worthwhile target for fruitful drug discovery . Regulation GPR115 ARRB1 12538596 1071255 and beta-arrestin2 *play* a key role in the regulation of [G protein coupled receptor] mediated signaling , whereas the subcellular distribution of beta-arrestin1 and beta-arrestin2 has been shown to be quite different . Regulation GPR115 ARRB2 12538596 1071256 beta-Arrestin1 and *play* a key role in the regulation of [G protein coupled receptor] mediated signaling , whereas the subcellular distribution of beta-arrestin1 and beta-arrestin2 has been shown to be quite different . Regulation GPR115 ARRDC1 24680432 2931042 *Role* of ß-arrestins and proteins in [G protein coupled receptor] trafficking . Regulation GPR115 ARRDC2 24680432 2931040 *Role* of ß-arrestins and proteins in [G protein coupled receptor] trafficking . Regulation GPR115 ARRDC3 24680432 2931043 *Role* of ß-arrestins and proteins in [G protein coupled receptor] trafficking . Regulation GPR115 ARRDC4 24680432 2931041 *Role* of ß-arrestins and proteins in [G protein coupled receptor] trafficking . Regulation GPR115 ARRDC5 24680432 2931044 *Role* of ß-arrestins and proteins in [G protein coupled receptor] trafficking . Regulation GPR115 CALM3 10496966 647358 The first mechanism is based on recent in vitro studies demonstrating that [G protein coupled receptor kinase (GRK)] activity , the protein kinase responsible for beta(2)-adrenergic receptor homologous phosphorylation and desensitization , may be *regulated* by and membrane phosphatidylinositol 4 , 5-bisphosphate . Regulation GPR115 CEP104 20067472 2233140 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP112 20067472 2233152 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP120 20067472 2233150 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP128 20067472 2233138 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP135 20067472 2233156 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP152 20067472 2233158 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP164 20067472 2233157 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP170 20067472 2233153 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP19 20067472 2233151 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP192 20067472 2233143 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP250 20067472 2233137 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP290 20067472 2233154 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP350 20067472 2233139 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP41 20067472 2233136 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP44 20067472 2233159 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP55 20067472 2233135 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP57 20067472 2233161 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP63 20067472 2233147 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP68 20067472 2233155 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP70 20067472 2233160 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP72 20067472 2233144 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP76 20067472 2233145 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP78 20067472 2233146 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP85 20067472 2233142 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP89 20067472 2233148 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP95 20067472 2233141 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CEP97 20067472 2233149 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR115 CSK 16501257 1541562 *Role* of tyrosine kinase in [G protein coupled receptor-] and receptor tyrosine kinase induced fibroblast cell migration . Regulation GPR115 CSK 8702633 375741 *Role* of in [G protein coupled receptor-] and Gbetagamma subunit mediated activation of mitogen activated protein kinases . Regulation GPR115 EGF 12880866 1115980 This is the first demonstration of a *role* of receptor transactivation in the phosphorylation of a [G protein coupled receptor] . Regulation GPR115 EGFR 11502566 847606 We examined the *role* of ( EGFR ) tyrosine kinase activation in [G protein coupled receptor (GPCR)] agonist induced mitogenesis in Swiss 3T3 and Rat-1 cells . Regulation GPR115 ESAM 18672896 1948120 *Regulation* of [G protein coupled receptor] activities by the , PECAM-1 . Regulation GPR115 FLNA 16513120 1535881 Using short interfering RNA ( siRNA ) to selectively target the filamin A gene and silence its expression , we studied the *role* of in [G protein coupled receptor (GPCR)] signaling . Regulation GPR115 GIP 20865381 2326199 *acts* on a [G-protein coupled receptor] that is widely distributed in the body including adipose tissue , stomach , brain , and others . Regulation GPR115 GNB2L1 18088317 1862519 *regulates* the cell surface expression of the [G protein coupled receptor] for thromboxane A ( 2 ) . Regulation GPR115 GRK1 17971124 1859393 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Regulation GPR115 GRK1 18056263 1853220 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Regulation GPR115 GRK4 17971124 1859395 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Regulation GPR115 GRK4 18056263 1853222 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Regulation GPR115 GRK5 17971124 1859396 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Regulation GPR115 GRK5 18056263 1853223 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Regulation GPR115 GRK6 17971124 1859397 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Regulation GPR115 GRK6 18056263 1853224 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Regulation GPR115 GRK7 17971124 1859394 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Regulation GPR115 GRK7 18056263 1853221 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Regulation GPR115 HSPG2 20227493 2244064 Among phospholipase C (PLC) isozymes ( beta , gamma , delta , epsilon , zeta and eta ) , *plays* a key role in [G-protein coupled receptor (GPCR)] mediated signaling . Regulation GPR115 IL1B 11704539 879145 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR115 INS 15388645 1354140 Substitution of the C-terminal cytoplasmic tail of the beta2-adrenergic receptor on the beta1-adrenergic receptor enabled the chimeric [G protein coupled receptor] to be functionally and spatially *regulated* by . Regulation GPR115 MAP3K5 11815436 907672 *Involvement* of nuclear factor-kappaB and in [G-protein coupled receptor] agonist induced cardiomyocyte hypertrophy . Regulation GPR115 NFKB1 11815436 907973 In this study , we examined the *role* of an ROS-sensitive transcriptional factor , , and a mitogen activated protein kinase kinase kinase , apoptosis signal regulating kinase 1 ( ASK1 ) , in [G-protein coupled receptor (GPCR)] agonist ( angiotensin II , endothelin-1 , phenylephrine ) -induced cardiac hypertrophy in isolated rat neonatal cardiomyocytes . Regulation GPR115 PITX2 10836135 697873 In this review we discuss what has been learned so far about the *role* of proteins in regulating [G protein coupled receptor] signaling and point out areas that may be fruitful for future research . Regulation GPR115 PITX2 15313556 1285583 *play* a critical role in [G-protein coupled receptor] signaling in mammalian cells . Regulation GPR115 PITX2 16647283 1583412 Cellular mechanisms that determine selective protein *regulation* of [G protein coupled receptor] signaling . Regulation GPR115 RELA 11815436 907974 In this study , we examined the *role* of an ROS-sensitive transcriptional factor , , and a mitogen activated protein kinase kinase kinase , apoptosis signal regulating kinase 1 ( ASK1 ) , in [G-protein coupled receptor (GPCR)] agonist ( angiotensin II , endothelin-1 , phenylephrine ) -induced cardiac hypertrophy in isolated rat neonatal cardiomyocytes . Regulation GPR115 RGS18 17074726 1638150 Our results suggest that [G-protein coupled receptor] mediated signalling in platelet may be *regulated* mainly by , 16 , 10 , 6 , and LARG . Regulation GPR115 RGS2 15292363 1278780 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR115 RGS2 19427970 2076923 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR115 RGS3 9182581 434811 A truncated form of negatively *regulates* [G protein coupled receptor] stimulation of adenylyl cyclase and phosphoinositide phospholipase C . Regulation GPR115 RIC8A 23212907 2736461 The *regulation* of the [GPR-Ga] ( i1 ) complex by , as well as the ability of Ric-8A to restore Ga expression in Ric8A ( -/- ) mouse embryonic stem cells , involved two helical domains at the carboxyl terminus of Ric-8A . Regulation GPR115 RTP4 18495679 1951733 If expression *affects* [G protein coupled receptor] function , it may be important for establishment of pregnancy in domestic ruminants . Regulation GPR115 SLC39A14 21445361 2412285 The zinc transporter *controls* [G-protein coupled receptor] mediated signaling required for systemic growth . Regulation GPR115 SLC9A3R1 23454118 2760444 is a known regulator of EGF-R function and *plays* numerous roles in [G-protein coupled receptor] signalling . Regulation GPR115 SST 8806621 382433 *Role* of in modulating [G protein coupled receptor] signaling . Regulation GPR115 TNF 11704539 879144 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR115 TRH 20352046 2231364 T ( 3 ) negatively regulates TSHalpha gene expression via thyroid hormone receptors ( TRs ) which belong to the nuclear hormone receptor superfamily , whereas positively *regulates* via the TRH receptor , a [G protein coupled receptor] . Regulation GPR115 VEGFA 11289142 800496 Here , we describe that this constitutively active [G protein coupled receptor] is able to promote cell survival in primary human umbilical vein endothelial cells and that this effect is *independent* of its ability to secrete because it is not prevented by the expression of antisense constructs for VEGF or the addition of VEGF blocking antibodies . Regulation GPR116 IL1B 11704539 879147 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR116 RGS2 15292363 1278781 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR116 RGS2 19427970 2076924 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR116 TNF 11704539 879146 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR119 IL1B 11704539 879149 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR119 RGS2 15292363 1278782 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR119 RGS2 19427970 2076925 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR119 TNF 11704539 879148 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR12 IL1B 11704539 879207 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR12 RGS2 15292363 1278811 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR12 RGS2 19427970 2076954 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR12 TNF 11704539 879206 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR123 IL1B 11704539 879111 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR123 RGS2 15292363 1278763 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR123 RGS2 19427970 2076906 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR123 TNF 11704539 879110 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR124 IL1B 11704539 879129 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR124 RGS2 15292363 1278772 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR124 RGS2 19427970 2076915 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR124 TNF 11704539 879128 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR125 IL1B 11704539 879113 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR125 RGS2 15292363 1278764 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR125 RGS2 19427970 2076907 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR125 TNF 11704539 879112 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR126 IL1B 11704539 879115 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR126 RGS2 15292363 1278765 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR126 RGS2 19427970 2076908 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR126 TNF 11704539 879114 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR128 IL1B 11704539 879151 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR128 RGS2 15292363 1278783 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR128 RGS2 19427970 2076926 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR128 TNF 11704539 879150 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR132 ADCY6 10779394 687327 We investigated the *effect* of adenovirally mediated overexpression of , a major form of AC expressed in mammalian heart , on [G protein coupled receptor] regulation of cAMP production in neonatal rat ventricular myocytes . Regulation GPR132 ADRBK1 16339447 1491458 ( GRK2 ) *plays* a key role in the desensitization of [G protein coupled receptor] signaling by phosphorylating activated heptahelical receptors and by sequestering heterotrimeric G proteins . Regulation GPR132 ADRBK1 16725308 1624750 ( GRK2 ) *plays* a key role in the modulation of [G-protein-coupled-receptor (GPCR)] signaling by both phosphorylating agonist occupied GPCRs and by directly binding to activated Galphaq subunits , inhibiting downstream effectors activation . Regulation GPR132 ADRBK1 19815545 2164370 Our results suggest a novel mechanism by which negatively *regulates* [G protein coupled receptor] signaling in a manner that is independent of receptor phosphorylation . Regulation GPR132 ADRBK1 20080565 2205784 ( GRK2 ) *plays* a central role in [G protein coupled receptor] regulation . Regulation GPR132 ALB 11122451 758546 Natural killer cell dependent immunoglobulin [G2a] anti-bovine ( BSA ) *response* elicited by high molecular weight dextran-BSA conjugates associated with dextran mediated macrophage-natural killer cell interaction . Regulation GPR132 ANXA1 15955733 1427861 In addition , aspirin triggered epi-lipoxins and glucocorticoid regulated might *act* on the same [G-protein coupled receptor] , thus rendering this shared receptor a more likely and worthwhile target for fruitful drug discovery . Regulation GPR132 ARRB1 12538596 1071233 and beta-arrestin2 *play* a key role in the regulation of [G protein coupled receptor] mediated signaling , whereas the subcellular distribution of beta-arrestin1 and beta-arrestin2 has been shown to be quite different . Regulation GPR132 ARRB2 12538596 1071234 beta-Arrestin1 and *play* a key role in the regulation of [G protein coupled receptor] mediated signaling , whereas the subcellular distribution of beta-arrestin1 and beta-arrestin2 has been shown to be quite different . Regulation GPR132 ARRDC1 24680432 2930987 *Role* of ß-arrestins and proteins in [G protein coupled receptor] trafficking . Regulation GPR132 ARRDC2 24680432 2930985 *Role* of ß-arrestins and proteins in [G protein coupled receptor] trafficking . Regulation GPR132 ARRDC3 24680432 2930988 *Role* of ß-arrestins and proteins in [G protein coupled receptor] trafficking . Regulation GPR132 ARRDC4 24680432 2930986 *Role* of ß-arrestins and proteins in [G protein coupled receptor] trafficking . Regulation GPR132 ARRDC5 24680432 2930989 *Role* of ß-arrestins and proteins in [G protein coupled receptor] trafficking . Regulation GPR132 CALM3 10496966 647347 The first mechanism is based on recent in vitro studies demonstrating that [G protein coupled receptor kinase (GRK)] activity , the protein kinase responsible for beta(2)-adrenergic receptor homologous phosphorylation and desensitization , may be *regulated* by and membrane phosphatidylinositol 4 , 5-bisphosphate . Regulation GPR132 CEP104 20067472 2232843 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP112 20067472 2232855 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP120 20067472 2232853 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP128 20067472 2232841 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP135 20067472 2232859 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP152 20067472 2232861 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP164 20067472 2232860 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP170 20067472 2232856 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP19 20067472 2232854 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP192 20067472 2232846 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP250 20067472 2232840 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP290 20067472 2232857 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP350 20067472 2232842 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP41 20067472 2232839 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP44 20067472 2232862 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP55 20067472 2232838 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP57 20067472 2232864 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP63 20067472 2232850 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP68 20067472 2232858 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP70 20067472 2232863 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP72 20067472 2232847 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP76 20067472 2232848 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP78 20067472 2232849 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP85 20067472 2232845 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP89 20067472 2232851 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP95 20067472 2232844 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CEP97 20067472 2232852 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR132 CSK 16501257 1541551 *Role* of tyrosine kinase in [G protein coupled receptor-] and receptor tyrosine kinase induced fibroblast cell migration . Regulation GPR132 CSK 8702633 375730 *Role* of in [G protein coupled receptor-] and Gbetagamma subunit mediated activation of mitogen activated protein kinases . Regulation GPR132 DNAJC5 10992502 732926 Intradermal injection of the CSP genetic vaccine induced a strong Th1-type immune response characterized by a dominant immunoglobulin [G2a] ( IgG2a ) humoral *response* and high levels of gamma interferon produced by splenic T cells . Regulation GPR132 EGF 12880866 1115969 This is the first demonstration of a *role* of receptor transactivation in the phosphorylation of a [G protein coupled receptor] . Regulation GPR132 EGFR 11502566 847595 We examined the *role* of epidermal growth factor (EGF) receptor ( ) tyrosine kinase activation in [G protein coupled receptor (GPCR)] agonist induced mitogenesis in Swiss 3T3 and Rat-1 cells . Regulation GPR132 ESAM 18672896 1948109 *Regulation* of [G protein coupled receptor] activities by the , PECAM-1 . Regulation GPR132 FLNA 16513120 1535870 Using short interfering RNA ( siRNA ) to selectively target the filamin A gene and silence its expression , we studied the *role* of in [G protein coupled receptor (GPCR)] signaling . Regulation GPR132 GIP 20865381 2326188 *acts* on a [G-protein coupled receptor] that is widely distributed in the body including adipose tissue , stomach , brain , and others . Regulation GPR132 GNB2L1 18088317 1862508 *regulates* the cell surface expression of the [G protein coupled receptor] for thromboxane A ( 2 ) . Regulation GPR132 GRK1 17971124 1859338 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Regulation GPR132 GRK1 18056263 1853165 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Regulation GPR132 GRK4 17971124 1859340 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Regulation GPR132 GRK4 18056263 1853167 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Regulation GPR132 GRK5 17971124 1859341 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Regulation GPR132 GRK5 18056263 1853168 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Regulation GPR132 GRK6 17971124 1859342 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Regulation GPR132 GRK6 18056263 1853169 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Regulation GPR132 GRK7 17971124 1859339 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Regulation GPR132 GRK7 18056263 1853166 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Regulation GPR132 HSPG2 20227493 2244053 Among phospholipase C (PLC) isozymes ( beta , gamma , delta , epsilon , zeta and eta ) , *plays* a key role in [G-protein coupled receptor (GPCR)] mediated signaling . Regulation GPR132 IL1B 11704539 879123 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR132 INS 15388645 1354129 Substitution of the C-terminal cytoplasmic tail of the beta2-adrenergic receptor on the beta1-adrenergic receptor enabled the chimeric [G protein coupled receptor] to be functionally and spatially *regulated* by . Regulation GPR132 MAP3K5 11815436 907661 *Involvement* of nuclear factor-kappaB and in [G-protein coupled receptor] agonist induced cardiomyocyte hypertrophy . Regulation GPR132 NFKB1 11815436 907951 In this study , we examined the *role* of an ROS-sensitive transcriptional factor , , and a mitogen activated protein kinase kinase kinase , apoptosis signal regulating kinase 1 ( ASK1 ) , in [G-protein coupled receptor (GPCR)] agonist ( angiotensin II , endothelin-1 , phenylephrine ) -induced cardiac hypertrophy in isolated rat neonatal cardiomyocytes . Regulation GPR132 PITX2 10836135 697862 In this review we discuss what has been learned so far about the *role* of proteins in regulating [G protein coupled receptor] signaling and point out areas that may be fruitful for future research . Regulation GPR132 PITX2 15313556 1285572 *play* a critical role in [G-protein coupled receptor] signaling in mammalian cells . Regulation GPR132 PITX2 16647283 1583401 Cellular mechanisms that determine selective protein *regulation* of [G protein coupled receptor] signaling . Regulation GPR132 RELA 11815436 907952 In this study , we examined the *role* of an ROS-sensitive transcriptional factor , , and a mitogen activated protein kinase kinase kinase , apoptosis signal regulating kinase 1 ( ASK1 ) , in [G-protein coupled receptor (GPCR)] agonist ( angiotensin II , endothelin-1 , phenylephrine ) -induced cardiac hypertrophy in isolated rat neonatal cardiomyocytes . Regulation GPR132 RGS18 17074726 1638139 Our results suggest that [G-protein coupled receptor] mediated signalling in platelet may be *regulated* mainly by , 16 , 10 , 6 , and LARG . Regulation GPR132 RGS2 15292363 1278769 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR132 RGS2 19427970 2076912 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR132 RGS3 9182581 434800 A truncated form of negatively *regulates* [G protein coupled receptor] stimulation of adenylyl cyclase and phosphoinositide phospholipase C . Regulation GPR132 RIC8A 23212907 2736450 The *regulation* of the [GPR-Ga] ( i1 ) complex by , as well as the ability of Ric-8A to restore Ga expression in Ric8A ( -/- ) mouse embryonic stem cells , involved two helical domains at the carboxyl terminus of Ric-8A . Regulation GPR132 RTP4 18495679 1951722 If expression *affects* [G protein coupled receptor] function , it may be important for establishment of pregnancy in domestic ruminants . Regulation GPR132 SLC39A14 21445361 2412274 The zinc transporter *controls* [G-protein coupled receptor] mediated signaling required for systemic growth . Regulation GPR132 SLC9A3R1 23454118 2760433 is a known regulator of EGF-R function and *plays* numerous roles in [G-protein coupled receptor] signalling . Regulation GPR132 SST 8806621 382422 *Role* of in modulating [G protein coupled receptor] signaling . Regulation GPR132 TNF 11704539 879122 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR132 TRH 20352046 2231353 T ( 3 ) negatively regulates TSHalpha gene expression via thyroid hormone receptors ( TRs ) which belong to the nuclear hormone receptor superfamily , whereas positively *regulates* via the TRH receptor , a [G protein coupled receptor] . Regulation GPR132 VEGFA 11289142 800485 Here , we describe that this constitutively active [G protein coupled receptor] is able to promote cell survival in primary human umbilical vein endothelial cells and that this effect is *independent* of its ability to secrete because it is not prevented by the expression of antisense constructs for VEGF or the addition of VEGF blocking antibodies . Regulation GPR133 IL1B 11704539 879153 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR133 RGS2 15292363 1278784 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR133 RGS2 19427970 2076927 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR133 TNF 11704539 879152 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR135 IL1B 11704539 879155 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR135 RGS2 15292363 1278785 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR135 RGS2 19427970 2076928 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR135 TNF 11704539 879154 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR137 IL1B 11704539 879191 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR137 RGS2 15292363 1278803 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR137 RGS2 19427970 2076946 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR137 TNF 11704539 879190 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR139 IL1B 11704539 879157 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR139 RGS2 15292363 1278786 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR139 RGS2 19427970 2076929 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR139 TNF 11704539 879156 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR141 IL1B 11704539 879159 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR141 RGS2 15292363 1278787 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR141 RGS2 19427970 2076930 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR141 TNF 11704539 879158 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR142 IL1B 11704539 879161 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR142 RGS2 15292363 1278788 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR142 RGS2 19427970 2076931 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR142 TNF 11704539 879160 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR143 IL1B 11704539 879163 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR143 RGS2 15292363 1278789 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR143 RGS2 19427970 2076932 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR143 TNF 11704539 879162 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR144 IL1B 11704539 879133 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR144 RGS2 15292363 1278774 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR144 RGS2 19427970 2076917 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR144 TNF 11704539 879132 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR146 IL1B 11704539 879167 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR146 RGS2 15292363 1278791 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR146 RGS2 19427970 2076934 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR146 TNF 11704539 879166 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR148 IL1B 11704539 879175 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR148 RGS2 15292363 1278795 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR148 RGS2 19427970 2076938 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR148 TNF 11704539 879174 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR149 IL1B 11704539 879179 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR149 RGS2 15292363 1278797 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR149 RGS2 19427970 2076940 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR149 TNF 11704539 879178 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR15 IL1B 11704539 879209 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR15 RGS2 15292363 1278812 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR15 RGS2 19427970 2076955 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR15 TNF 11704539 879208 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR150 IL1B 11704539 879181 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR150 RGS2 15292363 1278798 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR150 RGS2 19427970 2076941 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR150 TNF 11704539 879180 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR151 IL1B 11704539 879177 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR151 RGS2 15292363 1278796 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR151 RGS2 19427970 2076939 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR151 TNF 11704539 879176 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR152 IL1B 11704539 879173 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR152 RGS2 15292363 1278794 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR152 RGS2 19427970 2076937 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR152 TNF 11704539 879172 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR153 IL1B 11704539 879171 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR153 RGS2 15292363 1278793 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR153 RGS2 19427970 2076936 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR153 TNF 11704539 879170 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR155 IL1B 11704539 879169 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR155 RGS2 15292363 1278792 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR155 RGS2 19427970 2076935 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR155 TNF 11704539 879168 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR156 IL1B 11704539 879165 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR156 RGS2 15292363 1278790 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR156 RGS2 19427970 2076933 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR156 TNF 11704539 879164 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR157 IL1B 11704539 879183 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR157 RGS2 15292363 1278799 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR157 RGS2 19427970 2076942 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR157 TNF 11704539 879182 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR158 IL1B 11704539 879185 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR158 RGS2 15292363 1278800 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR158 RGS2 19427970 2076943 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR158 TNF 11704539 879184 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR160 IL1B 11704539 879187 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR160 RGS2 15292363 1278801 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR160 RGS2 19427970 2076944 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR160 TNF 11704539 879186 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR161 IL1B 11704539 879189 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR161 RGS2 15292363 1278802 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR161 RGS2 19427970 2076945 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR161 TNF 11704539 879188 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR162 IL1B 11704539 879119 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR162 RGS2 15292363 1278767 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR162 RGS2 19427970 2076910 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR162 TNF 11704539 879118 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR17 IL1B 11704539 879211 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR17 RGS2 15292363 1278813 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR17 RGS2 19427970 2076956 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR17 TNF 11704539 879210 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR171 IL1B 11704539 879195 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR171 RGS2 15292363 1278805 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR171 RGS2 19427970 2076948 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR171 TNF 11704539 879194 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR173 IL1B 11704539 879131 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR173 RGS2 15292363 1278773 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR173 RGS2 19427970 2076916 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR173 TNF 11704539 879130 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR174 IL1B 11704539 879197 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR174 RGS2 15292363 1278806 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR174 RGS2 19427970 2076949 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR174 TNF 11704539 879196 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR176 IL1B 11704539 879203 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR176 RGS2 15292363 1278809 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR176 RGS2 19427970 2076952 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR176 TNF 11704539 879202 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR179 IL1B 11704539 879201 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR179 RGS2 15292363 1278808 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR179 RGS2 19427970 2076951 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR179 TNF 11704539 879200 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR18 IL1B 11704539 879213 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR18 RGS2 15292363 1278814 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR18 RGS2 19427970 2076957 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR18 TNF 11704539 879212 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR180 IL1B 11704539 879193 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR180 RGS2 15292363 1278804 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR180 RGS2 19427970 2076947 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR180 TNF 11704539 879192 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR182 IL1B 11704539 879107 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR182 RGS2 15292363 1278761 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR182 RGS2 19427970 2076904 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR182 TNF 11704539 879106 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR183 IL1B 11704539 879199 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR183 RGS2 15292363 1278807 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR183 RGS2 19427970 2076950 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR183 TNF 11704539 879198 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR19 IL1B 11704539 879215 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR19 RGS2 15292363 1278815 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR19 RGS2 19427970 2076958 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR19 TNF 11704539 879214 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR20 IL1B 11704539 879217 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR20 RGS2 15292363 1278816 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR20 RGS2 19427970 2076959 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR20 TNF 11704539 879216 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR21 IL1B 11704539 879219 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR21 RGS2 15292363 1278817 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR21 RGS2 19427970 2076960 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR21 TNF 11704539 879218 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR22 GPR115 18539757 1945702 Myocardial expression , signaling , and function of [GPR22] : a protective *role* for an orphan . Regulation GPR22 GPR132 18539757 1945691 Myocardial expression , signaling , and function of [GPR22] : a protective *role* for an orphan . Regulation GPR22 GPR87 18539757 1945771 Myocardial expression , signaling , and function of [GPR22] : a protective *role* for an orphan . Regulation GPR22 IL1B 11704539 879221 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR22 RGS2 15292363 1278818 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR22 RGS2 19427970 2076961 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR22 TNF 11704539 879220 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR25 IL1B 11704539 879223 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR25 RGS2 15292363 1278819 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR25 RGS2 19427970 2076962 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR25 TNF 11704539 879222 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR26 IL1B 11704539 879225 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR26 RGS2 15292363 1278820 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR26 RGS2 19427970 2076963 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR26 TNF 11704539 879224 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR27 IL1B 11704539 879227 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR27 RGS2 15292363 1278821 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR27 RGS2 19427970 2076964 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR27 TNF 11704539 879226 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR3 IL1B 11704539 879229 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR3 RGS2 15292363 1278822 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR3 RGS2 19427970 2076965 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR3 TNF 11704539 879228 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR31 IL1B 11704539 879231 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR31 RGS2 15292363 1278823 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR31 RGS2 19427970 2076966 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR31 TNF 11704539 879230 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR32 IL1B 11704539 879233 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR32 RGS2 15292363 1278824 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR32 RGS2 19427970 2076967 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR32 TNF 11704539 879232 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR33 IL1B 11704539 879235 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR33 RGS2 15292363 1278825 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR33 RGS2 19427970 2076968 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR33 TNF 11704539 879234 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR34 IL1B 11704539 879237 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR34 RGS2 15292363 1278826 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR34 RGS2 19427970 2076969 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR34 TNF 11704539 879236 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR35 IL1B 11704539 879239 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR35 RGS2 15292363 1278827 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR35 RGS2 19427970 2076970 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR35 TNF 11704539 879238 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR36 IL1B 11704539 879241 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR36 RGS2 15292363 1278828 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR36 RGS2 19427970 2076971 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR36 TNF 11704539 879240 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR37 IL1B 11704539 879243 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR37 RGS2 15292363 1278829 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR37 RGS2 19427970 2076972 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR37 TNF 11704539 879242 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR39 GPR115 18337590 1912397 Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory *role* of , [GPR39] . Regulation GPR39 GPR132 18337590 1912386 Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory *role* of , [GPR39] . Regulation GPR39 GPR87 18337590 1912466 Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory *role* of , [GPR39] . Regulation GPR39 IL1B 11704539 879245 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR39 RGS2 15292363 1278830 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR39 RGS2 19427970 2076973 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR39 TNF 11704539 879244 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR4 IL1B 11704539 879247 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR4 RGS2 15292363 1278831 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR4 RGS2 19427970 2076974 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR4 TNF 11704539 879246 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR42 IL1B 11704539 879249 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR42 RGS2 15292363 1278832 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR42 RGS2 19427970 2076975 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR42 TNF 11704539 879248 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR45 IL1B 11704539 879251 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR45 RGS2 15292363 1278833 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR45 RGS2 19427970 2076976 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR45 TNF 11704539 879250 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR50 IL1B 11704539 879253 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR50 RGS2 15292363 1278834 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR50 RGS2 19427970 2076977 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR50 TNF 11704539 879252 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR52 IL1B 11704539 879255 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR52 RGS2 15292363 1278835 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR52 RGS2 19427970 2076978 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR52 TNF 11704539 879254 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR55 IL1B 11704539 879257 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR55 RGS2 15292363 1278836 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR55 RGS2 19427970 2076979 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR55 TNF 11704539 879256 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR56 IL1B 11704539 879259 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR56 RGS2 15292363 1278837 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR56 RGS2 19427970 2076980 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR56 TNF 11704539 879258 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR6 IL1B 11704539 879261 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR6 RGS2 15292363 1278838 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR6 RGS2 19427970 2076981 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR6 TNF 11704539 879260 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR61 IL1B 11704539 879101 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR61 RGS2 15292363 1278758 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR61 RGS2 19427970 2076901 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR61 TNF 11704539 879100 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR62 IL1B 11704539 879103 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR62 RGS2 15292363 1278759 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR62 RGS2 19427970 2076902 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR62 TNF 11704539 879102 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR63 IL1B 11704539 879105 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR63 RGS2 15292363 1278760 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR63 RGS2 19427970 2076903 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR63 TNF 11704539 879104 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR64 IL1B 11704539 879263 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR64 RGS2 15292363 1278839 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR64 RGS2 19427970 2076982 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR64 TNF 11704539 879262 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR65 IL1B 11704539 879265 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR65 RGS2 15292363 1278840 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR65 RGS2 19427970 2076983 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR65 TNF 11704539 879264 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR68 IL1B 11704539 879267 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR68 RGS2 15292363 1278841 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR68 RGS2 19427970 2076984 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR68 TNF 11704539 879266 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR75 IL1B 11704539 879271 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR75 RGS2 15292363 1278843 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR75 RGS2 19427970 2076986 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR75 TNF 11704539 879270 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR78 IL1B 11704539 879273 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR78 RGS2 15292363 1278844 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR78 RGS2 19427970 2076987 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR78 TNF 11704539 879272 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR79 IL1B 11704539 879275 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR79 RGS2 15292363 1278845 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR79 RGS2 19427970 2076988 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR79 TNF 11704539 879274 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR82 IL1B 11704539 879277 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR82 RGS2 15292363 1278846 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR82 RGS2 19427970 2076989 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR82 TNF 11704539 879276 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR83 IL1B 11704539 879269 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR83 RGS2 15292363 1278842 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR83 RGS2 19427970 2076985 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR83 TNF 11704539 879268 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR84 IL1B 11704539 879279 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR84 RGS2 15292363 1278847 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR84 RGS2 19427970 2076990 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR84 TNF 11704539 879278 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR85 IL1B 11704539 879281 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR85 RGS2 15292363 1278848 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR85 RGS2 19427970 2076991 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR85 TNF 11704539 879280 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR87 ADCY6 10779394 687407 We investigated the *effect* of adenovirally mediated overexpression of , a major form of AC expressed in mammalian heart , on [G protein coupled receptor] regulation of cAMP production in neonatal rat ventricular myocytes . Regulation GPR87 ADRBK1 16339447 1491538 ( GRK2 ) *plays* a key role in the desensitization of [G protein coupled receptor] signaling by phosphorylating activated heptahelical receptors and by sequestering heterotrimeric G proteins . Regulation GPR87 ADRBK1 16725308 1624830 ( GRK2 ) *plays* a key role in the modulation of [G-protein-coupled-receptor (GPCR)] signaling by both phosphorylating agonist occupied GPCRs and by directly binding to activated Galphaq subunits , inhibiting downstream effectors activation . Regulation GPR87 ADRBK1 19815545 2164450 Our results suggest a novel mechanism by which negatively *regulates* [G protein coupled receptor] signaling in a manner that is independent of receptor phosphorylation . Regulation GPR87 ADRBK1 20080565 2205864 ( GRK2 ) *plays* a central role in [G protein coupled receptor] regulation . Regulation GPR87 ANXA1 15955733 1427941 In addition , aspirin triggered epi-lipoxins and glucocorticoid regulated might *act* on the same [G-protein coupled receptor] , thus rendering this shared receptor a more likely and worthwhile target for fruitful drug discovery . Regulation GPR87 ARRB1 12538596 1071393 and beta-arrestin2 *play* a key role in the regulation of [G protein coupled receptor] mediated signaling , whereas the subcellular distribution of beta-arrestin1 and beta-arrestin2 has been shown to be quite different . Regulation GPR87 ARRB2 12538596 1071394 beta-Arrestin1 and *play* a key role in the regulation of [G protein coupled receptor] mediated signaling , whereas the subcellular distribution of beta-arrestin1 and beta-arrestin2 has been shown to be quite different . Regulation GPR87 ARRDC1 24680432 2931387 *Role* of ß-arrestins and proteins in [G protein coupled receptor] trafficking . Regulation GPR87 ARRDC2 24680432 2931385 *Role* of ß-arrestins and proteins in [G protein coupled receptor] trafficking . Regulation GPR87 ARRDC3 24680432 2931388 *Role* of ß-arrestins and proteins in [G protein coupled receptor] trafficking . Regulation GPR87 ARRDC4 24680432 2931386 *Role* of ß-arrestins and proteins in [G protein coupled receptor] trafficking . Regulation GPR87 ARRDC5 24680432 2931389 *Role* of ß-arrestins and proteins in [G protein coupled receptor] trafficking . Regulation GPR87 CALM3 10496966 647427 The first mechanism is based on recent in vitro studies demonstrating that [G protein coupled receptor kinase (GRK)] activity , the protein kinase responsible for beta(2)-adrenergic receptor homologous phosphorylation and desensitization , may be *regulated* by and membrane phosphatidylinositol 4 , 5-bisphosphate . Regulation GPR87 CEP104 20067472 2235003 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP112 20067472 2235015 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP120 20067472 2235013 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP128 20067472 2235001 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP135 20067472 2235019 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP152 20067472 2235021 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP164 20067472 2235020 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP170 20067472 2235016 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP19 20067472 2235014 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP192 20067472 2235006 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP250 20067472 2235000 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP290 20067472 2235017 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP350 20067472 2235002 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP41 20067472 2234999 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP44 20067472 2235022 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP55 20067472 2234998 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP57 20067472 2235024 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP63 20067472 2235010 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP68 20067472 2235018 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP70 20067472 2235023 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP72 20067472 2235007 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP76 20067472 2235008 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP78 20067472 2235009 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP85 20067472 2235005 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP89 20067472 2235011 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP95 20067472 2235004 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CEP97 20067472 2235012 We investigated the *effect* of a MLK1-3 inhibitor on [G protein coupled receptor] agonist induced stress response in neonatal rat cardiac myocytes in culture . Regulation GPR87 CSK 16501257 1541631 *Role* of tyrosine kinase in [G protein coupled receptor-] and receptor tyrosine kinase induced fibroblast cell migration . Regulation GPR87 CSK 8702633 375810 *Role* of in [G protein coupled receptor-] and Gbetagamma subunit mediated activation of mitogen activated protein kinases . Regulation GPR87 EGF 12880866 1116049 This is the first demonstration of a *role* of receptor transactivation in the phosphorylation of a [G protein coupled receptor] . Regulation GPR87 EGFR 11502566 847675 We examined the *role* of ( EGFR ) tyrosine kinase activation in [G protein coupled receptor (GPCR)] agonist induced mitogenesis in Swiss 3T3 and Rat-1 cells . Regulation GPR87 ESAM 18672896 1948189 *Regulation* of [G protein coupled receptor] activities by the , PECAM-1 . Regulation GPR87 FLNA 16513120 1535950 Using short interfering RNA ( siRNA ) to selectively target the filamin A gene and silence its expression , we studied the *role* of in [G protein coupled receptor (GPCR)] signaling . Regulation GPR87 GIP 20865381 2326268 *acts* on a [G-protein coupled receptor] that is widely distributed in the body including adipose tissue , stomach , brain , and others . Regulation GPR87 GNB2L1 18088317 1862588 *regulates* the cell surface expression of the [G protein coupled receptor] for thromboxane A ( 2 ) . Regulation GPR87 GRK1 17971124 1859738 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Regulation GPR87 GRK1 18056263 1853565 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Regulation GPR87 GRK4 17971124 1859740 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Regulation GPR87 GRK4 18056263 1853567 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Regulation GPR87 GRK5 17971124 1859741 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Regulation GPR87 GRK5 18056263 1853568 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Regulation GPR87 GRK6 17971124 1859742 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Regulation GPR87 GRK6 18056263 1853569 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Regulation GPR87 GRK7 17971124 1859739 2 ( GRK2 ) *regulates* [G protein coupled receptor] signaling via agonist induced receptor phosphorylation and desensitization . Regulation GPR87 GRK7 18056263 1853566 This study not only helps us understand the endogenous agonist dependent beta ( 2 ) AR signaling in animal heart but also offers an example of how [G protein coupled receptor] signaling may be finely *regulated* by in physiological settings . Regulation GPR87 HSPG2 20227493 2244133 Among phospholipase C (PLC) isozymes ( beta , gamma , delta , epsilon , zeta and eta ) , *plays* a key role in [G-protein coupled receptor (GPCR)] mediated signaling . Regulation GPR87 IL1B 11704539 879283 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR87 INS 15388645 1354209 Substitution of the C-terminal cytoplasmic tail of the beta2-adrenergic receptor on the beta1-adrenergic receptor enabled the chimeric [G protein coupled receptor] to be functionally and spatially *regulated* by . Regulation GPR87 MAP3K5 11815436 907741 *Involvement* of nuclear factor-kappaB and in [G-protein coupled receptor] agonist induced cardiomyocyte hypertrophy . Regulation GPR87 NFKB1 11815436 908111 In this study , we examined the *role* of an ROS-sensitive transcriptional factor , , and a mitogen activated protein kinase kinase kinase , apoptosis signal regulating kinase 1 ( ASK1 ) , in [G-protein coupled receptor (GPCR)] agonist ( angiotensin II , endothelin-1 , phenylephrine ) -induced cardiac hypertrophy in isolated rat neonatal cardiomyocytes . Regulation GPR87 PITX2 10836135 697942 In this review we discuss what has been learned so far about the *role* of proteins in regulating [G protein coupled receptor] signaling and point out areas that may be fruitful for future research . Regulation GPR87 PITX2 15313556 1285652 *play* a critical role in [G-protein coupled receptor] signaling in mammalian cells . Regulation GPR87 PITX2 16647283 1583481 Cellular mechanisms that determine selective protein *regulation* of [G protein coupled receptor] signaling . Regulation GPR87 RELA 11815436 908112 In this study , we examined the *role* of an ROS-sensitive transcriptional factor , , and a mitogen activated protein kinase kinase kinase , apoptosis signal regulating kinase 1 ( ASK1 ) , in [G-protein coupled receptor (GPCR)] agonist ( angiotensin II , endothelin-1 , phenylephrine ) -induced cardiac hypertrophy in isolated rat neonatal cardiomyocytes . Regulation GPR87 RGS18 17074726 1638219 Our results suggest that [G-protein coupled receptor] mediated signalling in platelet may be *regulated* mainly by , 16 , 10 , 6 , and LARG . Regulation GPR87 RGS2 15292363 1278849 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR87 RGS2 19427970 2076992 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR87 RGS3 9182581 434880 A truncated form of negatively *regulates* [G protein coupled receptor] stimulation of adenylyl cyclase and phosphoinositide phospholipase C . Regulation GPR87 RIC8A 23212907 2736530 The *regulation* of the [GPR-Ga] ( i1 ) complex by , as well as the ability of Ric-8A to restore Ga expression in Ric8A ( -/- ) mouse embryonic stem cells , involved two helical domains at the carboxyl terminus of Ric-8A . Regulation GPR87 RTP4 18495679 1951802 If expression *affects* [G protein coupled receptor] function , it may be important for establishment of pregnancy in domestic ruminants . Regulation GPR87 SLC39A14 21445361 2412447 The zinc transporter *controls* [G-protein coupled receptor] mediated signaling required for systemic growth . Regulation GPR87 SLC9A3R1 23454118 2760513 is a known regulator of EGF-R function and *plays* numerous roles in [G-protein coupled receptor] signalling . Regulation GPR87 SST 8806621 382502 *Role* of in modulating [G protein coupled receptor] signaling . Regulation GPR87 TNF 11704539 879282 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR87 TP53 19602589 2112105 Here , we found that [G protein coupled receptor 87 (GPR87)] was up-regulated by p53 and by DNA damage in a *dependent* manner . Regulation GPR87 TRH 20352046 2231433 T ( 3 ) negatively regulates TSHalpha gene expression via thyroid hormone receptors ( TRs ) which belong to the nuclear hormone receptor superfamily , whereas positively *regulates* via the TRH receptor , a [G protein coupled receptor] . Regulation GPR87 VEGFA 11289142 800565 Here , we describe that this constitutively active [G protein coupled receptor] is able to promote cell survival in primary human umbilical vein endothelial cells and that this effect is *independent* of its ability to secrete because it is not prevented by the expression of antisense constructs for VEGF or the addition of VEGF blocking antibodies . Regulation GPR88 IL1B 11704539 879285 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR88 RGS2 15292363 1278850 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR88 RGS2 19427970 2076993 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR88 TNF 11704539 879284 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR97 IL1B 11704539 879109 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR97 RGS2 15292363 1278762 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR97 RGS2 19427970 2076905 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR97 TNF 11704539 879108 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR98 IL1B 11704539 879121 In this study , we examined the mechanisms by which and TNF-alpha *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPR98 RGS2 15292363 1278768 ( RGS-2 ) *plays* a key role in the [G protein coupled receptor (GPCR)] angiotensin II (Ang II) signaling . Regulation GPR98 RGS2 19427970 2076911 The cardiac ( RGS2 ) negatively *regulates* [G-protein coupled receptor] signaling . Regulation GPR98 TNF 11704539 879120 In this study , we examined the mechanisms by which IL-1 beta and *affect* inhibition of cell growth , [G protein coupled receptor (GPCR)] desensitization , and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures . Regulation GPX1 ABCA12 7696980 288087 The *effect* of chlorpromazine and on the superoxide dismutase and [glutathione peroxidase] activities of rat brain , liver and erythrocytes . Regulation GPX2 ABCA12 7696980 288089 The *effect* of chlorpromazine and on the superoxide dismutase and [glutathione peroxidase] activities of rat brain , liver and erythrocytes . Regulation GPX3 ABCA12 7696980 288091 The *effect* of chlorpromazine and on the superoxide dismutase and [glutathione peroxidase] activities of rat brain , liver and erythrocytes . Regulation GPX4 ABCA12 7696980 288093 The *effect* of chlorpromazine and on the superoxide dismutase and [glutathione peroxidase] activities of rat brain , liver and erythrocytes . Regulation GPX5 ABCA12 7696980 288095 The *effect* of chlorpromazine and on the superoxide dismutase and [glutathione peroxidase] activities of rat brain , liver and erythrocytes . Regulation GPX6 ABCA12 7696980 288097 The *effect* of chlorpromazine and on the superoxide dismutase and [glutathione peroxidase] activities of rat brain , liver and erythrocytes . Regulation GPX7 ABCA12 7696980 288099 The *effect* of chlorpromazine and on the superoxide dismutase and [glutathione peroxidase] activities of rat brain , liver and erythrocytes . Regulation GPX8 ABCA12 7696980 288085 The *effect* of chlorpromazine and on the superoxide dismutase and [glutathione peroxidase] activities of rat brain , liver and erythrocytes . Regulation GRAP2 EPHB2 10629859 576459 In contrast with H2O2 induced activation of , the activation of ERK induced by phorbol ester PMA and the activation of JNK and [p38] induced by H2O2 were not *affected* by expression of GRK2-ct , indicating that the activation of ERK but not JNK and p38 is dependent on beta gamma subunit . Regulation GRAP2 EPHB2 11745456 888986 These findings suggest that both and cellular protein tyrosine kinase activation are involved in 12 ( S ) -HETE induced pancreatic cancer cell proliferation but [P38] and JNK/SAPK are not *involved* in this mitogenic effect . Regulation GRAP2 EPHB2 12087068 959420 PTX mediated [p38] MAP kinase activation did not *involve* either p42/p44 , p60src , Rho family of GTPases , or phosphatidylinositol-3' kinase pathways . Regulation GRAP2 EPHB2 23443666 2765653 IFN-? and GM-CSF production requires NF-?B and STAT3 activation as well as *dependent* mechanisms for IFN-? and [p38] signaling for GM-CSF . Regulation GRAP2 FAS 10200443 561092 Here , we demonstrate that receptor triggered activation of the acidic sphingomyelinase , consumption of sphingomyelin , release of ceramide , and subsequent activation of JNK and [p38-K] are *regulated* by caspases . Regulation GRAP2 FAS 12556535 1071635 Apoptosis signal regulating kinase 1 ( ASK1 ) is a MAP kinase kinase kinase ( MAPKKK ) that is required for c-Jun N-terminal kinase (JNK) and [p38] activation in *response* to and tumor necrosis factor (TNF) receptor stimulation , and for oxidative stress- and TNFalpha induced apoptosis . Regulation GRAP2 IL1B 15831571 1417982 Activation of [p38] and ERK in *response* to was also dependent on L-type Ca ( 2+ ) influx . Regulation GRAP2 IL1B 17337443 1726638 IRAK-4 KD cells are severely impaired in NFkappaB , JNK , and [p38] activation in *response* to or TLR7 ligand . Regulation GRAP2 IL1B 18510099 1840592 IRAK-4 KD cells were severely impaired in NF-kappaB , JNK , and [p38] activation in *response* to or TLR7 ligand . Regulation GRAP2 IL1B 19435930 2106995 *Regulation* of tristetraprolin expression by and dexamethasone in human pulmonary epithelial cells : roles for nuclear factor-kappa B and [p38] mitogen activated protein kinase . Regulation GRAP2 MAP2K6 15790570 1410263 To investigate the effect of enhanced p38 MAPK activity on endothelial cell function , we expressed an activated mutant of ( MEK6E ) , an upstream *regulator* of [p38] . Regulation GRAP2 MAP2K6 15923604 1413883 Cells deficient in Mkk3 and , the upstream *regulators* of [p38alpha] , also fail to activate HIF-1 under hypoxic conditions . Regulation GRAP2 MAP2K6 16342939 1491918 We now demonstrate that selectivity pocket compounds prevent *dependent* activation of [p38alpha] in addition to inhibiting catalysis by activated p38alpha . Regulation GRAP2 PGC 20955697 2407038 Finally , inhibition of PPAR? activation by a PPAR? antagonist GW9662 abolished the suppressive *effects* of on [p38] MAPK phosphorylation and VSMC migration . Regulation GRAP2 SLC38A3 11208554 787170 To study the role of p38 kinase in G17 signaling to Akt , we examined the *effect* of on [p38] kinase activation and phosphorylation using kinase assays and Western blots with an anti-phospho-p38 kinase antibody . Regulation GRAP2 SPHK1 15993704 1429720 Inhibition of also did not *affect* EGF stimulated phosphorylation of PI-3 kinase , Akt , ERK1/2 or [p38] but inhibition of PI-3 kinase with a specific inhibitor LY294002 partly ( 40 % ) inhibited the EGF stimulated increase in SPHK-1 activity . Regulation GRAP2 SPHK1 20498849 2263720 In addition , our results also unraveled a novel *regulation* of [p38MAPK] by during M. smegmatis infection and generation of NO in macrophages . Regulation GRAP2 SPHK1 21233411 2409054 These results define a pathway leading to NOX2 activation , in which [p38] MAPK mediated S100A8/A9 translocation is *regulated* by Ca ( 2+ ) store depletion dependent activation . Regulation GRAP2 TNF 14585994 1159355 Taken together , these studies suggest a mechanism whereby RIP1 may mediate the [p38] MAP kinase *response* to , by recruiting the MAP3K MEKK3 . Regulation GRAP2 TNF 14632659 1170630 In the present study , we analysed the *effects* of and 2,4-dinitrochlorobenzene ( DNCB ) on phenotypic maturation and [p38] mitogen activated protein kinase (MAPK) activity , using a murine DC line . Regulation GRAP2 TNF 16081599 1460405 These results indicate that gp120 elicited production by macrophages involves chemokine receptor mediated PI-3K and MAPK activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that [p38] and ERK-1/2 independently *regulate* TNF-alpha production . Regulation GRAP2 TNF 17151142 1732366 To fully evaluate the *role* of in myogenic activation of [p38] , we tried to determine whether p38 activation in differentiating myoblasts requires autocrine TNF-alpha , and whether forced activation of p38 rescues impaired myogenesis and regeneration in the p55 ( -/- ) p75 ( -/- ) soleus . Regulation GRAP2 TNF 17438131 1742721 Overexpression of alpha-4 suppressed [p38] MAPK activation in *response* to . Regulation GRAP2 TNF 17500068 1761795 TNFR1 , but not TNFR2 , also mediates a potent *effect* of on the phosphorylation of JNK1/2 and [p38] stress activated protein kinase and their downstream transcription factor substrates c-Jun and activating transcription factor 2 ( ATF2 ) . Regulation GRAP2 TNF 19429670 2106821 Then , we examined the *effect* of Ang II and/or on phosphorylation of extracellular signal regulated kinase ( ERK ) , [p38MAPK] , and IkappaB-alpha . Regulation GRAP2 TNF 22800929 2645765 In vitro , we examined the effects of IF inhibition on production and the *regulation* of ERK1/2 and [p38] phosphorylation activity in LPS induced mouse peritoneal macrophages . Regulation GRB10 JAG1 19592644 2111972 Importantly , [GrB] *response* to viral was significantly stronger in B cells from subjects recently vaccinated against the corresponding viruses as compared with unvaccinated subjects . Regulation GRB10 TNF 17258890 1725468 The *effects* of and FasL on [GrB] expression were specifically mediated by p38MAPK ( Mitogen-activated-protein-kinase ) activation . Regulation GRB14 JAG1 19592644 2111973 Importantly , [GrB] *response* to viral was significantly stronger in B cells from subjects recently vaccinated against the corresponding viruses as compared with unvaccinated subjects . Regulation GRB14 TNF 17258890 1725470 The *effects* of and FasL on [GrB] expression were specifically mediated by p38MAPK ( Mitogen-activated-protein-kinase ) activation . Regulation GRB2 JAG1 19592644 2111974 Importantly , [GrB] *response* to viral was significantly stronger in B cells from subjects recently vaccinated against the corresponding viruses as compared with unvaccinated subjects . Regulation GRB2 TNF 14687710 1179596 *Regulation* of [GRB2] and FLICE2 expression by in rheumatoid synovium . Regulation GRB2 TNF 17258890 1725472 The *effects* of and FasL on [GrB] expression were specifically mediated by p38MAPK ( Mitogen-activated-protein-kinase ) activation . Regulation GRB7 JAG1 19592644 2111975 Importantly , [GrB] *response* to viral was significantly stronger in B cells from subjects recently vaccinated against the corresponding viruses as compared with unvaccinated subjects . Regulation GRB7 TNF 17258890 1725474 The *effects* of and FasL on [GrB] expression were specifically mediated by p38MAPK ( Mitogen-activated-protein-kinase ) activation . Regulation GRIA1 CAPN8 17234699 1717929 Biochemical and immunocytochemical studies demonstrated that in cortical cultures , prolonged glutamate or NMDA treatment reduced the level of surface and total [GluR1] , but not GluR2 , subunits in a *dependent* manner . Regulation GRIA1 IL1B 16626814 1562842 The inhibition of NMDA receptor activity or depletion of extracellular calcium blocked *effects* on [GluR1] phosphorylation and surface expression . Regulation GRIA2 CAPN8 17234699 1717943 Biochemical and immunocytochemical studies demonstrated that in cortical cultures , prolonged glutamate or NMDA treatment reduced the level of surface and total GluR1 , but not [GluR2] , subunits in a *dependent* manner . Regulation GRIK2 FOS 11925568 926741 Moreover , *regulates* the expression of the kainic acid receptor [GluR6] and brain derived neurotrophic factor (BDNF) , both in vivo and in vitro . Regulation GRIN2A CAPN8 18445709 1938563 Animals exposed to transient forebrain ischemia , a condition that activates calpain , exhibited the reduced NMDAR current density and the lower full-length [NR2A/B] level in a *dependent* manner . Regulation GRIN2B CAPN8 19118186 2004768 Expression of recombinant TTBK1 in primary mouse cortical neurons significantly downregulated [NR2B] in a CDK5- and *dependent* manner . Regulation GRK5 CTGF 23778361 2824130 In conclusion , this study uncovers a novel mechanism controlling ß-AR responsiveness in cardiomyocytes involving mediated *regulation* of [GRK5] . Regulation GRK5 MIP 12592402 1064320 We also show that lipopolysaccharide (LPS) activated signaling through the Toll-like receptor (TLR)-4 pathway transcriptionally downregulates the expression of GRK2 and [GRK5] in *response* to . Regulation GRM1 EPHB2 12437585 1016200 The [mGlu1a] receptor mediated *response* was almost completely attenuated by pertussis toxin (PTx) pretreatment , whereas the mGlu5a-ERK response , and the phosphoinositide response to activation of either receptor , was PTx-insensitive . Regulation GRM1 SLC1A6 19289926 2046806 At cerebellar climbing fiber-Purkinje cell synapse , EAAT4 and metabotropic glutamate receptor 1 ( mGluR1 ) are closely expressed in surrounding postsynaptic locations , suggesting that may *regulate* [mGluR1] activation . Regulation GRM5 EPHB2 24167026 2889720 These data indicate that [Homer1c-mGluR5] interactions are necessary for mGluR dependent LTP , and that mGluR1/5 dependent LTP *involves* PI3K and activation . Regulation GSDMA TNF 22585037 2643398 These results , taken together , indicated that in mouse skin keratinocytes , [Gsdma3] expression could be *regulated* by . Regulation GSK3B AXIN2 10490650 645611 Based on these data , we propose that the complex may directly *regulate* [GSK-3beta] enzymatic activity in vivo . Regulation GSK3B CAPN8 19714564 2293536 *Regulation* of [GSK-3beta] by in the 3-nitropropionic acid model . Regulation GSK3B EPHB2 16150462 1475641 The activity of [GSK3beta] , a downstream target of these pathways , was negatively *regulated* by the activation of both and PI3K/Akt . Regulation GSK3B RCAN1 16649988 1557383 We also show that [GSK-3beta] is *regulated* by at a post-transcriptional level . Regulation GSK3B RCAN1 16649988 1557395 While can *regulate* calcineurin and [GSK-3beta] , it has also been shown that calcineurin and GSK-3beta can regulate RCAN1s . Regulation GSK3B TNF 15026145 1222579 The *effects* of on insulin induced phosphorylation of protein kinase B-alpha (PKB-alpha) and downstream enzyme [glycogen synthase kinase-3 beta] ( GSK-3 beta ) was examined in HepG2 liver cells . Regulation GSK3B TNF 17158207 1694196 Western blot analysis of L6 cell lysates demonstrated impaired insulin stimulated phosphorylation of Akt , serine/arginine-rich protein 40 , and [glycogen synthase kinase 3beta] in *response* to and the short chain C6 ceramide analog . Regulation GSK3B TNF 17158207 1694203 *Effects* of and C6 on insulin stimulated phosphorylation of [glycogen synthase kinase 3beta] were prevented by myriocin and tautomycin , a PP1 inhibitor , further implicating a de novo ceramide-PP1 pathway . Regulation GSPT1 CCND1 10667569 665633 Because *plays* an important role in the [G1 to S phase transition] of the cell cycle , our findings suggest that cells with the mutant allele accumulate mutations as a result of defective mismatch repair and may also bypass the G1-S checkpoint of the cell cycle more easily than in cells not carrying the polymorphism . Regulation GSPT1 CCND1 17043650 1716356 It is reported to *regulate* [G1 to S phase transition] of the cell cycle by influencing the expression , protein stability and subcellular location of . Regulation GSPT1 CCND1 22024187 2507993 *regulates* the [G1-to-S phase transition] . Regulation GSPT1 IFI27 17510234 1766836 It has also been shown that the retinoblastoma protein RB *regulates* the [G(1) to S phase transition] of the cell cycle by controlling the activity of transcription factors and stabilizing the levels of the cell cycle inhibitor . Regulation GSPT1 TCN1 18959821 1982910 Taken together , our findings revealed that was *involved* in the mitogen activated ERK1/2 signaling pathway and positively regulated [G(1)- to S-phase transition] of the cell cycle . Regulation GSPT2 CCND1 10667569 665634 Because *plays* an important role in the [G1 to S phase transition] of the cell cycle , our findings suggest that cells with the mutant allele accumulate mutations as a result of defective mismatch repair and may also bypass the G1-S checkpoint of the cell cycle more easily than in cells not carrying the polymorphism . Regulation GSPT2 CCND1 17043650 1716357 It is reported to *regulate* [G1 to S phase transition] of the cell cycle by influencing the expression , protein stability and subcellular location of . Regulation GSPT2 CCND1 22024187 2507994 *regulates* the [G1-to-S phase transition] . Regulation GSPT2 IFI27 17510234 1766837 It has also been shown that the retinoblastoma protein RB *regulates* the [G(1) to S phase transition] of the cell cycle by controlling the activity of transcription factors and stabilizing the levels of the cell cycle inhibitor . Regulation GSPT2 TCN1 18959821 1982911 Taken together , our findings revealed that was *involved* in the mitogen activated ERK1/2 signaling pathway and positively regulated [G(1)- to S-phase transition] of the cell cycle . Regulation GSTP1 TNF 15013838 1220705 Here we investigated the *regulation* of the [GSTP1-1] gene expression in the K562 cell line by nuclear factor kappaB (NF-kappaB) and the pro-inflammatory cytokine . Regulation GSTT1 ARSA 9729437 530145 We now investigated whether the NSAIDs indomethacin , relafen , sulindac , ibuprofen , piroxicam , and , incorporated individually into the diet at 25 , 200 , 320 , 400 , 400 and 400 mg/kg , respectively , *affect* gastrointestinal [GSTT1-1] and GSTT2-2 levels in male Wistar rats . Regulation GSTT2 ARSA 9729437 530146 We now investigated whether the NSAIDs indomethacin , relafen , sulindac , ibuprofen , piroxicam , and , incorporated individually into the diet at 25 , 200 , 320 , 400 , 400 and 400 mg/kg , respectively , *affect* gastrointestinal GSTT1-1 and [GSTT2-2] levels in male Wistar rats . Regulation GTF2B LBP 7836461 293693 Here we have analyzed the *effect* of recombinant on [HIV-1 transcription] in vitro by using a `` pulse-chase '' assay . Regulation GTF2B LBP 7836461 293694 In addition , Tat was found to suppress the antiprocessivity *effect* of on [HIV-1 transcription] in nuclear extracts . Regulation GTF2I EPHB2 10648599 662104 These results suggest that *regulates* the activity of [TFII-I] by direct phosphorylation . Regulation GYS1 TNF 9832415 551728 The *effects* of on glucose uptake and [glycogen synthase (GS)] activity were studied in human skeletal muscle cell cultures from nondiabetic and type 2 diabetic subjects . Regulation GYS2 TNF 9832415 551729 The *effects* of on glucose uptake and [glycogen synthase (GS)] activity were studied in human skeletal muscle cell cultures from nondiabetic and type 2 diabetic subjects . Regulation GZMB TNF 23284789 2711624 The cytotoxicity of IL-15 DCs is predominantly mediated by [granzyme B] and , to a small extent , by tumor necrosis factor-a (TNF-a) related apoptosis inducing ligand ( TRAIL ) but is *independent* of perforin , Fas ligand and . Regulation HAMP IL1B 16198622 1496325 Although the induction of hepcidin by an inflammatory cytokine interleukin-6 (IL-6) seems to have been confirmed , it is still controversial whether , also known as an inflammatory cytokine , *regulates* [hepcidin] expression . Regulation HAMP IL1B 16198622 1496328 Although IL-1beta induces IL-6 production in hepatocytes , our data indicate that the *effect* of on [hepcidin] expression is independent from that of IL-6 . Regulation HAMP PGC 23438894 2760228 *regulates* hepatic [hepcidin] expression and iron homeostasis in response to inflammation . Regulation HAMP PGC 23438894 2760233 Our data suggest a critical *role* for in the regulation of hepatic [HAMP] expression and iron homeostasis under inflammatory circumstances . Regulation HAMP TF 17540841 1784188 Iron *regulates* [hepcidin] synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4 . Regulation HAMP TF 17540841 1784189 Paradoxically , in previous studies in primary hepatocytes and cell lines , [hepcidin] *response* to iron or iron was not observed . Regulation HAMP TF 19047682 2047370 We hypothesized that *plays* a critical role both in iron transport and in regulating [hepcidin] expression in zebrafish embryos . Regulation HAMP TF 20634490 2334907 Implications for dependent [hepcidin] *regulation* . Regulation HAMP TF 20956801 2375981 To investigate the *role* of in the regulation of [hepcidin] expression by these factors in vivo , we employed the hypotransferrinemic ( hpx ) mouse . Regulation HAMP TF 21245482 2397941 Hfe and are *involved* in the homeostatic regulation of [hepcidin] and their disruption causes hereditary hemochromatosis (HH) . Regulation HAMP TF 21993681 2539646 Here we investigate the *regulation* of [hepcidin] , a hormone that inhibits dietary iron absorption and macrophage iron recycling , by the serum iron binding protein . Regulation HAMP TF 22085723 2557365 Emphasis is given on the *role* of on iron dependent [hepcidin] regulation . Regulation HAMP TNF 16221503 1517849 Regulatory *effects* of and interleukin-6 on [HAMP] expression in iron loaded rat hepatocytes . Regulation HAMP TNF 16221503 1517860 *regulates* the mRNA levels of [HAMP] , IREG1 , DMT1 and TfR2 in cultured hepatocytes from both iron loaded and control animals . Regulation HAMP TNF 17255318 1691064 These results contrast with previous data demonstrating that [hepcidin] levels are directly *regulated* by interleukin-6 but not by . Regulation HAMP TNF 19008338 2016504 Regulation of liver [hepcidin] expression by alcohol in vivo does not *involve* Kupffer cell activation or signaling . Regulation HAMP TNF 19008338 2016506 Our results demonstrate that alcohol induced Kupffer cell activation and signaling are not *involved* in the suppression of liver [hepcidin] expression by alcohol mediated oxidative stress in vivo . Regulation HAMP TNF 24286116 2877252 Serum hepcidin-25 reduction by the TNF-a inhibitor therapy was accompanied by a decrease in serum IL-6 , suggesting that the *effect* of on the induction of [hepcidin-25] was indirect . Regulation HAS1 IL1B 11389868 822408 *Regulation* of [hyaluronan synthase] gene expression in human periodontal ligament cells by tumour necrosis factor-alpha , and interferon-gamma . Regulation HAS1 IL1B 11389868 822416 These results suggest that TNF-alpha and *regulate* [HAS] expression , and consequently may result in an accumulation of HA and an increase in HA of a lower molecular-weight . Regulation HAS1 IL1B 15649434 1363889 These results indicate that [HAS] in the uterine cervix is *regulated* in a complex manner by , progesterone , and low-molecular-weight hyaluronan , of which changes in the cervical tissue and serum closely participate in uterine cervical ripening and/or inflammation . Regulation HAS1 IL1B 16258173 1489915 Overexpressing IkappaBalpha completely abolished the *effect* on [HAS1] but did not interfere with TGFbeta1 induced HAS1 mRNA accumulation . Regulation HAS1 IL1B 16786194 1638490 TNF-alpha , IFN-gamma , and *modulate* [hyaluronan synthase] expression in human skin fibroblasts : synergistic effect by concomital treatment with FeSO4 plus ascorbate . Regulation HAS1 IL1B 16904269 1672816 Such data indicate that the *effect* of on [HAS1] is mediated by prostaglandins . Regulation HAS1 IL1B 17868639 1843018 *Regulation* of [HAS] expression in human synovial lining cells of TMJ by . Regulation HAS1 IL1B 17868639 1843019 In the present study , we investigated the regulatory *roles* of on [HAS] gene expression and HA production by the fibroblastic synovial lining cells . Regulation HAS1 IL1B 19737932 2152800 This new technique was used to evaluate the *effects* of 4-methylumbeliferone , phorbol 12-myristate 13-acetate , , platelet derived growth factor BB , and tunicamycin on [HAS] activities . Regulation HAS1 TNF 11389868 822415 These results suggest that and IL-1beta *regulate* [HAS] expression , and consequently may result in an accumulation of HA and an increase in HA of a lower molecular-weight . Regulation HAS2 IL1B 11389868 822410 *Regulation* of [hyaluronan synthase] gene expression in human periodontal ligament cells by tumour necrosis factor-alpha , and interferon-gamma . Regulation HAS2 IL1B 16786194 1638491 TNF-alpha , IFN-gamma , and *modulate* [hyaluronan synthase] expression in human skin fibroblasts : synergistic effect by concomital treatment with FeSO4 plus ascorbate . Regulation HAS2 IL1B 18158910 1869254 Antibody-neutralization study revealed that KGF and/or were at least *involved* in the up-regulation of HAS3 and [HAS2] expressions . Regulation HAS3 IFNG 11389868 822411 *Regulation* of [hyaluronan synthase] gene expression in human periodontal ligament cells by tumour necrosis factor-alpha , interleukin-1beta and . Regulation HAS3 IL1B 11389868 822412 *Regulation* of [hyaluronan synthase] gene expression in human periodontal ligament cells by tumour necrosis factor-alpha , and interferon-gamma . Regulation HAS3 IL1B 16786194 1638492 TNF-alpha , IFN-gamma , and *modulate* [hyaluronan synthase] expression in human skin fibroblasts : synergistic effect by concomital treatment with FeSO4 plus ascorbate . Regulation HAS3 IL1B 18158910 1869255 Antibody-neutralization study revealed that KGF and/or were at least *involved* in the up-regulation of [HAS3] and HAS2 expressions . Regulation HAS3 NAGLU 14976384 1213033 Conversely , had no *effect* on the expression of [HAS3] transcripts . Regulation HAVCR2 MAP2K6 21621846 2470524 These results suggest the regulatory *role* of in [TIM-3] transcription by human CD4+ T cells and mast cells . Regulation HBB KLF9 16380451 1539809 Erythroid ( EKLF , KLF1 ) *plays* an important role in definitive erythropoiesis and [beta-globin] gene regulation but failure to rectify lethal fetal anemia upon correction of globin chain imbalance suggested additional critical EKLF target genes . Regulation HBB SRGN 18445056 1951498 FBG and have no effect on LV functions , but [HbA] ( 1C ) levels may *affect* diastolic parameters . Regulation HBD IL1B 15240151 1270114 In this study , we investigated the *effect* of on induction of [HBD-2] in A549 cells . Regulation HBEGF ADIPOQ 20152812 2220356 Then , we observed the *effects* of on cardiac hypertrophy and [HB-EGF] signaling in cultured neonatal rat cardiomyocytes and whole hearts of adiponectin-null mice . Regulation HBEGF ANGPT2 16554661 1574678 These data indicate that ERK activation is induced by ANG2 in podocytes by mechanisms involving *dependent* release of [HB-EGF] which , in turn , may act in an autocrine and paracrine fashion to stimulate ERK activity . Regulation HBEGF APOB 8122185 241982 The cytosolic free Ca2+ concentration [Ca2+ ] i and [dense tubular system (DTS)] of washed human platelets were *affected* by of 25 micrograms/ml at 37 degrees C for 10 minutes . Regulation HBEGF AREG 17986609 1826783 The observation of normal induction of uterine amphiregulin surrounding the blastocyst at the time of attachment in these conditional mutant mice suggests a compensatory *role* of for uterine loss of [HB-EGF] , preventing complete failure of pregnancy . Regulation HBEGF BAG1 11340068 842280 In addition , because *effects* of on regulated secretion of soluble [HB-EGF] were also identified , this interaction has the potential to alter the signaling capabilities of both the membrane anchored and the diffusible forms of the growth factor . Regulation HBEGF CCK 16885350 1596298 In conclusion , gastrin and the *play* significant roles in the induction of [HB-EGF] gene and protein expression and ectodomain shedding by H. pylori . Regulation HBEGF CD44 16724877 1663371 and ( 4 ) retinaldehyde induced proliferative response of keratinocytes is a *dependent* phenomenon and requires the presence of [HB-EGF] , erbB1 and matrix metalloproteinases . Regulation HBEGF CD44 21179550 2358304 Our results indicate that ( i ) RAL induced in vitro and in vivo keratinocyte proliferation is a *dependent* phenomenon and requires the presence of HA , [HB-EGF] , erbB1 and MMPs , ( ii ) RAL and HAFi show a synergy in vitro and in vivo in mouse skin , and ( iii ) the combination of RAL and HAFi seems to have an important therapeutic effect in dermatoporosis . Regulation HBEGF CDC73 7713868 298115 These results suggest a potential *role* of in [HB-EGF] expression and provide evidence that this stimulation may occur through increased kappa B binding activity . Regulation HBEGF CDX2 12223343 987729 These data indicate that [HB-EGF] gene expression can be *regulated* by and serves to mediate the control of Cdx2 of the proliferation and migration of IEC-6 cells . Regulation HBEGF CSF2 10556204 565893 The *effects* of on [HB-EGF] mRNA levels were concentration dependent , reached a plateau after 1 to 2 hours of stimulation , and did not require protein synthesis . Regulation HBEGF CTR9 7713868 298116 These results suggest a potential *role* of in [HB-EGF] expression and provide evidence that this stimulation may occur through increased kappa B binding activity . Regulation HBEGF ECM1 10210777 607664 We investigated whether the interaction of human monocytic THP-1 cells with the endothelial cell adhesion molecules ( vascular CAM-1 , VCAM-1 ; intercellular adhesion molecule-1 ICAM-1 and endothelial-selectin , E-selectin ) , or the proteins ( fibronectin , FN ; laminin , LN and fibrinogen , FG ) *regulate* [HB-EGF] expression . Regulation HBEGF ECM2 10210777 607665 We investigated whether the interaction of human monocytic THP-1 cells with the endothelial cell adhesion molecules ( vascular CAM-1 , VCAM-1 ; intercellular adhesion molecule-1 ICAM-1 and endothelial-selectin , E-selectin ) , or the proteins ( fibronectin , FN ; laminin , LN and fibrinogen , FG ) *regulate* [HB-EGF] expression . Regulation HBEGF EGF 10425274 632816 These results indicate that EGF and [HB-EGF] possess different functions in RGM-1 cells and that *acts* as a mediator of both cell maturation and apoptosis in these cells . Regulation HBEGF EGF 10548517 564907 To better understand this process , we examined the *effects* of receptor stimulation on the transcription and mRNA stability of TGF-alpha , amphiregulin (AR) , and [heparin binding EGF-like growth factor] ( HB-EGF ) in human keratinocytes . Regulation HBEGF EGF 11208719 787287 We determined the *role* of in stress induced expression of heparin binding EGF-like growth factor ( [HB-EGF] ) in a rat gastric epithelial cell line ( RGM1 cells ) . Regulation HBEGF EGF 19000772 2053398 Differential *regulation* of betacellulin and [heparin binding EGF-like growth factor] in cultured zebrafish ovarian follicle cells by family ligands . Regulation HBEGF EGFR 17395697 1748530 ligands in the chicken ovary : I. Evidence for heparin binding EGF-like growth factor ( HB-EGF ) as a potential oocyte derived signal to *control* granulosa cell proliferation and [HB-EGF] and kit ligand expression . Regulation HBEGF GAST 14764442 1242867 In this study , we investigated the *regulation* of the [HB-EGF] promoter by in a human gastric cancer cell line . Regulation HBEGF GRAP2 21413023 2404925 Moreover , our data suggest that both MAPKs and ERK1/2 are *involved* together or independently in the regulation of [HB-EGF] gene expression . Regulation HBEGF JUN 11530010 853769 Electrophoretic mobility shift assay also showed the *involvement* of in [HB-EGF] gene expression by glucose . Regulation HBEGF JUN 12791272 1097682 Thus , using three experimental systems , we show that EGFR and [HB-EGF] are *regulated* by , which controls eyelid development , keratinocyte proliferation , and skin tumor formation . Regulation HBEGF LANCL1 24043629 2857341 The *effects* of on [HB-EGF] release and ADAM17 activation in vivo are examined after administration of p40 containing pectin/zein hydrogel beads to mice . Regulation HBEGF LEO1 7713868 298119 These results suggest a potential *role* of in [HB-EGF] expression and provide evidence that this stimulation may occur through increased kappa B binding activity . Regulation HBEGF LPA 10354366 617773 The *effects* of and sphingosine 1-phosphate (S1P) on T cell expression of heparin binding epidermal growth factor-like growth factor ( [HB-EGF] ) , the diphtheria toxin ( DT ) receptor , were investigated in the Tsup-1 cultured line of human CD4+ 8+ 3low T lymphoblastoma cells . Regulation HBEGF LPA 17251460 1690996 The release of [HB-EGF] assessed by AP activity increased significantly in *response* to wounding , , or both , and the release of HB-EGF-AP induced by LPA was inhibited by PP2 and GM6001 . Regulation HBEGF MAPK1 23517395 2761764 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Regulation HBEGF MAPK10 23517395 2761765 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Regulation HBEGF MAPK11 23517395 2761766 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Regulation HBEGF MAPK12 23517395 2761767 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Regulation HBEGF MAPK13 23517395 2761768 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Regulation HBEGF MAPK14 23517395 2761769 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Regulation HBEGF MAPK15 23517395 2761763 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Regulation HBEGF MAPK3 21413023 2404920 [HB-EGF] synthesis and release induced by cholesterol depletion of human epidermal keratinocytes is controlled by extracellular ATP and *involves* both p38 and signaling pathways . Regulation HBEGF MAPK3 21413023 2404926 Moreover , our data suggest that both MAPKs p38 and are *involved* together or independently in the regulation of [HB-EGF] gene expression . Regulation HBEGF MAPK3 23517395 2761770 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Regulation HBEGF MAPK4 23517395 2761771 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Regulation HBEGF MAPK6 23517395 2761772 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Regulation HBEGF MAPK7 23517395 2761773 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Regulation HBEGF MAPK8 23517395 2761774 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Regulation HBEGF MAPK9 23517395 2761775 *regulates* leukotriene D4-induced [HB-EGF] and ADAM12 expression in human airway smooth muscle cells . Regulation HBEGF MBTPS1 10354366 617772 The *effects* of lysophosphatidic acid (LPA) and on T cell expression of heparin binding epidermal growth factor-like growth factor ( [HB-EGF] ) , the diphtheria toxin ( DT ) receptor , were investigated in the Tsup-1 cultured line of human CD4+ 8+ 3low T lymphoblastoma cells . Regulation HBEGF MYLIP 20856931 2319331 *Regulation* of [heparin binding EGF-like growth factor] by and acquired cetuximab-resistance in head and neck squamous cell carcinoma . Regulation HBEGF NPY6R 16799022 1579186 at a concentration as high as 50 microM exhibited no *effects* on [HB-EGF] induced ERK phosphorylation . Regulation HBEGF NRD1 16923819 1626838 These results indicate the essential *role* of in [HB-EGF] ectodomain shedding and reveal how the shedding is regulated by the modulation of sheddase activity . Regulation HBEGF PAF1 7713868 298117 These results suggest a potential *role* of in [HB-EGF] expression and provide evidence that this stimulation may occur through increased kappa B binding activity . Regulation HBEGF SHBG 16449863 1521973 Important modern prognostic markers such as heart rate recovery ( HRR ) , chronotropic index , delayed *response* and [Duke treadmill score (DTS)] have been evaluated by treadmill exercise testing . Regulation HBEGF SP1 20208558 2259507 Furthermore , we discover that induction of [HB-EGF] is dependent on reactive oxygen species and p38-MAPK signaling but not ERK and that the is *involved* in NPI-0052 induced HB-EGF transcription . Regulation HBEGF SRC 15143154 1273161 Although the Tyr319 residue of the AT1-R has been proposed to be an essential regulator of EGF-R transactivation , stimulation of wild-type and mutant ( Y319F ) AT1-R expressed in COS-7 cells caused EGF-R transactivation and subsequent ERK1/2 phosphorylation through release of [HB-EGF] in a *dependent* manner . Regulation HBEGF TNF 1577791 187541 In *response* to , [HB-EGF] mRNA levels quickly increased and peaked at 1 h , indicating that HB-EGF belongs to the family of immediate early genes . Regulation HBEGF UMOD 10210777 607668 In addition , we demonstrate that binding to LN , through the beta1 integrin VLA-6 , down *regulates* [HB-EGF] expression . Regulation HBEGF WDR61 7713868 298118 These results suggest a potential *role* of in [HB-EGF] expression and provide evidence that this stimulation may occur through increased kappa B binding activity . Regulation HBEGF ZGLP1 12437983 1016207 The current study has established the fact that glucose , , insulin , T ( 3 ) , [HB-EGF] , and TNF-alpha all positively *regulate* the PDX1 gene promoter in pancreatic beta-cells . Regulation HCFC1 PGC 22883232 2641819 O-GlcNAc [transferase/host cell factor C1] complex *regulates* gluconeogenesis by modulating stability . Regulation HCG11 TNF 10333360 614935 The aim of this study was to determine the *effects* of , interleukin-1 alpha (IL-1alpha) , macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases (MMP) , [human chorionic gonadotrophin (HCG)] and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro . Regulation HCG14 TNF 10333360 614942 The aim of this study was to determine the *effects* of , interleukin-1 alpha (IL-1alpha) , macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases (MMP) , [human chorionic gonadotrophin (HCG)] and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro . Regulation HCG15 TNF 10333360 614949 The aim of this study was to determine the *effects* of , interleukin-1 alpha (IL-1alpha) , macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases (MMP) , [human chorionic gonadotrophin (HCG)] and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro . Regulation HCG16 TNF 10333360 614970 The aim of this study was to determine the *effects* of , interleukin-1 alpha (IL-1alpha) , macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases (MMP) , [human chorionic gonadotrophin (HCG)] and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro . Regulation HCG17 TNF 10333360 615047 The aim of this study was to determine the *effects* of , interleukin-1 alpha (IL-1alpha) , macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases (MMP) , [human chorionic gonadotrophin (HCG)] and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro . Regulation HCG18 TNF 10333360 615040 The aim of this study was to determine the *effects* of , interleukin-1 alpha (IL-1alpha) , macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases (MMP) , [human chorionic gonadotrophin (HCG)] and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro . Regulation HCG20 TNF 10333360 615026 The aim of this study was to determine the *effects* of , interleukin-1 alpha (IL-1alpha) , macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases (MMP) , [human chorionic gonadotrophin (HCG)] and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro . Regulation HCG21 TNF 10333360 615033 The aim of this study was to determine the *effects* of , interleukin-1 alpha (IL-1alpha) , macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases (MMP) , [human chorionic gonadotrophin (HCG)] and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro . Regulation HCG22 TNF 10333360 615012 The aim of this study was to determine the *effects* of , interleukin-1 alpha (IL-1alpha) , macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases (MMP) , [human chorionic gonadotrophin (HCG)] and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro . Regulation HCG23 TNF 10333360 614956 The aim of this study was to determine the *effects* of , interleukin-1 alpha (IL-1alpha) , macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases (MMP) , [human chorionic gonadotrophin (HCG)] and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro . Regulation HCG24 TNF 10333360 614998 The aim of this study was to determine the *effects* of , interleukin-1 alpha (IL-1alpha) , macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases (MMP) , [human chorionic gonadotrophin (HCG)] and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro . Regulation HCG25 TNF 10333360 614963 The aim of this study was to determine the *effects* of , interleukin-1 alpha (IL-1alpha) , macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases (MMP) , [human chorionic gonadotrophin (HCG)] and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro . Regulation HCG26 TNF 10333360 615019 The aim of this study was to determine the *effects* of , interleukin-1 alpha (IL-1alpha) , macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases (MMP) , [human chorionic gonadotrophin (HCG)] and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro . Regulation HCG27 TNF 10333360 615005 The aim of this study was to determine the *effects* of , interleukin-1 alpha (IL-1alpha) , macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases (MMP) , [human chorionic gonadotrophin (HCG)] and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro . Regulation HCG4 TNF 10333360 614977 The aim of this study was to determine the *effects* of , interleukin-1 alpha (IL-1alpha) , macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases (MMP) , [human chorionic gonadotrophin (HCG)] and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro . Regulation HCG8 TNF 10333360 614984 The aim of this study was to determine the *effects* of , interleukin-1 alpha (IL-1alpha) , macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases (MMP) , [human chorionic gonadotrophin (HCG)] and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro . Regulation HCG9 TNF 10333360 614991 The aim of this study was to determine the *effects* of , interleukin-1 alpha (IL-1alpha) , macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases (MMP) , [human chorionic gonadotrophin (HCG)] and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro . Regulation HCL1 CA12 2864736 51543 Knowing the in vitro and in vivo gastric secretory effects of beta-adrenergic agonists and antagonists , as well as the *role* of in the gastric [HCl] production , we investigated the effect of some beta-adrenoceptor agonists ( isoprenaline and orciprenaline ) and antagonists ( propranolol , timolol , atenolol , pindolol , acebutolol , metoprolol , exoxprenolol ) on the purified , human red blood cell and gastric mucosa carbonic anhydrase . Regulation HCL1 CA12 9205766 440596 is a zinc enzyme , and its isozyme ( carbonic anhydrase II ) in parietal cells *plays* a central role in [HCl] secretion . Regulation HCL1 TNF 1588375 188478 In view of the pleomorphic role cytokines play in human lymphoproliferative disorders , we investigated the possible *involvement* of in [hairy cell leukemia (HCL)] . Regulation HCL1 TNF 2242429 144860 in contrast , the [HCL] proliferative *response* to SAC , , or IL-4 and IL-5 was not inhibited by anti-IL-6 Ab. alpha-Interferon inhibited the response to TPA/Ca2+ , TNF , or IL-4 and IL-5 without any effect on response to SAC . Regulation HCL1 TNF 9136953 427885 The pathogenetic *role* of in [HCL] prompted us to study the potential contribution of functionally important genetic polymorphisms of the TNF gene cluster in a large group of patients with HCL . Regulation HCL2 CA12 2864736 51556 Knowing the in vitro and in vivo gastric secretory effects of beta-adrenergic agonists and antagonists , as well as the *role* of in the gastric [HCl] production , we investigated the effect of some beta-adrenoceptor agonists ( isoprenaline and orciprenaline ) and antagonists ( propranolol , timolol , atenolol , pindolol , acebutolol , metoprolol , exoxprenolol ) on the purified , human red blood cell and gastric mucosa carbonic anhydrase . Regulation HCL2 CA12 9205766 440609 is a zinc enzyme , and its isozyme ( carbonic anhydrase II ) in parietal cells *plays* a central role in [HCl] secretion . Regulation HCL2 TNF 1588375 188479 In view of the pleomorphic role cytokines play in human lymphoproliferative disorders , we investigated the possible *involvement* of in [hairy cell leukemia (HCL)] . Regulation HCL2 TNF 2242429 144863 in contrast , the [HCL] proliferative *response* to SAC , , or IL-4 and IL-5 was not inhibited by anti-IL-6 Ab. alpha-Interferon inhibited the response to TPA/Ca2+ , TNF , or IL-4 and IL-5 without any effect on response to SAC . Regulation HCL2 TNF 9136953 427886 The pathogenetic *role* of in [HCL] prompted us to study the potential contribution of functionally important genetic polymorphisms of the TNF gene cluster in a large group of patients with HCL . Regulation HCL3 CA12 2864736 51569 Knowing the in vitro and in vivo gastric secretory effects of beta-adrenergic agonists and antagonists , as well as the *role* of in the gastric [HCl] production , we investigated the effect of some beta-adrenoceptor agonists ( isoprenaline and orciprenaline ) and antagonists ( propranolol , timolol , atenolol , pindolol , acebutolol , metoprolol , exoxprenolol ) on the purified , human red blood cell and gastric mucosa carbonic anhydrase . Regulation HCL3 CA12 9205766 440622 is a zinc enzyme , and its isozyme ( carbonic anhydrase II ) in parietal cells *plays* a central role in [HCl] secretion . Regulation HCL3 TNF 1588375 188480 In view of the pleomorphic role cytokines play in human lymphoproliferative disorders , we investigated the possible *involvement* of in [hairy cell leukemia (HCL)] . Regulation HCL3 TNF 2242429 144866 in contrast , the [HCL] proliferative *response* to SAC , , or IL-4 and IL-5 was not inhibited by anti-IL-6 Ab. alpha-Interferon inhibited the response to TPA/Ca2+ , TNF , or IL-4 and IL-5 without any effect on response to SAC . Regulation HCL3 TNF 9136953 427887 The pathogenetic *role* of in [HCL] prompted us to study the potential contribution of functionally important genetic polymorphisms of the TNF gene cluster in a large group of patients with HCL . Regulation HDAC1 PGC 23564453 2789120 Transcriptional and translational regulation of [C/EBPß-HDAC1] protein complexes *controls* different levels of p53 , SIRT1 , and proteins at the early and late stages of liver cancer . Regulation HDAC2 LRRN2 24679734 2930918 RW stimulation of the murine macrophage cell line RAW264.7 was used to determine *effects* of ASHMI active compound on tumor necrosis factor a (TNF-a) production and regulation of phosphorylated I?B and [histone deacetylase 2 (HDAC2)] levels . Regulation HDAC2 TNF 24679734 2930917 RW stimulation of the murine macrophage cell line RAW264.7 was used to determine effects of ASHMI active compound ganoderic acid C1 (GAC1) on production and *regulation* of phosphorylated I?B and [histone deacetylase 2 (HDAC2)] levels . Regulation HDAC3 TGM2 20004474 2199805 ChIP assay showed that , through interaction with NF-kappaB , was *responsible* for the induction of [histone deacetylase-3 (HDAC3)] and snail by direct binding to promoter sequences . Regulation HDAC3 TNF 16371367 1519657 In this study , we demonstrate that nuclear translocation of [HDAC3] is *regulated* by , and this event is required for inhibition of transcriptional activity of PPARgamma by TNF-alpha . Regulation HDC IL1B 7810664 284988 ( 5 micrograms/kg iv ) significantly inhibited basal acid secretion but did not *affect* basal urinary histamine excretion and fundic [histidine decarboxylase (HDC)] activity . Regulation HDC IL1B 7810664 284992 Pretreatment with indomethacin ( 10 mg/kg ip ) partially reversed the inhibitory *effects* of on gastrin stimulated fundic [HDC] activity and acid secretion . Regulation HDGF TNF 18465786 1927334 Moreover the + CHX-treatment did not *affect* the nuclear localization of [GFP-HDGF] . Regulation HES1 JAG1 22998557 2679103 mediated Notch signaling *regulates* hair cell ( HC ) production in a distinct way rather than lateral inhibition mediated by [Hes1] and Hes5 . Regulation HES2 NOTCH1 16682003 1559722 Here we show that Hrt2 and Hes1 interact with RBP-Jkappa to negatively regulate *dependent* activation of Hrt and [Hes] expression . Regulation HES2 NOTCH1 19386663 2075022 Interestingly , unlike other developmental contexts in which [Hes] gene expression is *regulated* by signaling , Hairy1 expression in the CMZ is regulated by Wnt signaling . Regulation HES2 NOTCH2 16682003 1559723 Here we show that Hrt2 and Hes1 interact with RBP-Jkappa to negatively regulate *dependent* activation of Hrt and [Hes] expression . Regulation HES2 NOTCH2 19386663 2075023 Interestingly , unlike other developmental contexts in which [Hes] gene expression is *regulated* by signaling , Hairy1 expression in the CMZ is regulated by Wnt signaling . Regulation HES2 NOTCH3 16682003 1559724 Here we show that Hrt2 and Hes1 interact with RBP-Jkappa to negatively regulate *dependent* activation of Hrt and [Hes] expression . Regulation HES2 NOTCH3 19386663 2075024 Interestingly , unlike other developmental contexts in which [Hes] gene expression is *regulated* by signaling , Hairy1 expression in the CMZ is regulated by Wnt signaling . Regulation HES2 NOTCH4 16682003 1559725 Here we show that Hrt2 and Hes1 interact with RBP-Jkappa to negatively regulate *dependent* activation of Hrt and [Hes] expression . Regulation HES2 NOTCH4 19386663 2075025 Interestingly , unlike other developmental contexts in which [Hes] gene expression is *regulated* by signaling , Hairy1 expression in the CMZ is regulated by Wnt signaling . Regulation HES5 JAG1 22998557 2679098 mediated Notch signaling *regulates* hair cell ( HC ) production in a distinct way rather than lateral inhibition mediated by Hes1 and [Hes5] . Regulation HFE TF 17003411 1618382 [HFE] is the principal regulator of iron homeostasis , and the process *involves* interaction with , transferrin receptor (TfR)-2 , and beta2-microglobulin (beta2M) . Regulation HFE TF 17428702 1742301 Here we report the setting up of a stable transfection model of wt- and mutant-HFE ( H63D and C282Y ) proteins in a hepatic cell line ( HepG2 ) , the analysis of its intracellular distribution and the *effect* of diferric on [HFE] localization . Regulation HFE TNF 12940442 1133278 Our aim was to study the *role* of and its promoter polymorphisms in the phenotypic expression of [hemochromatosis] in individuals with and without the C282Y mutation . Regulation HGF CD14 8945531 400310 We therefore investigated the *role* of , an LPS receptor , in stimulation of [HGF] by LPS . Regulation HGF EPHB2 16327976 1503569 Furthermore , the [hepatocyte growth factor] and epidermal growth factor induced Mcl-1 expression in an Akt- and *dependent* manner . Regulation HGF IL1B 1384479 200562 The tumor promoter , tetradecanoylphorbol 13-acetate ( TPA ) markedly enhanced the stimulatory *effect* of IL-1 alpha and on the production of [HGF] . Regulation HGF IL1B 9220246 442534 To determine whether interleukin 1 beta (IL-1 beta) messenger RNA ( mRNA ) and protein were expressed in corneal cells and to examine the *effects* of IL-1 alpha and on the expression of [hepatocyte growth factor (HGF)] and keratinocyte growth factor (KGF) mRNAs and proteins in corneal stromal fibroblasts . Regulation HGF IL1B 9220246 442538 Changes in the expression of [HGF] and KGF mRNAs and proteins in *response* to stimulation of cultured corneal stromal fibroblasts with IL-1 alpha and were monitored by Northern and Western blotting , respectively . Regulation HGF JAG1 16403414 1513224 Furthermore , *controls* [HGF] expression by a dosage dependent regulation and Notch2 signaling seems to mediate JAG1 function . Regulation HGF MMP28 19134348 2005742 To investigate the mechanism of *regulations* of [human gingival fibroblasts (HGF)] by challenge of Porphyromonas gingivalis ( Pg ) with different fimA genotypes . Regulation HGF MMP7 19134348 2005757 To investigate the mechanism of *regulations* of [human gingival fibroblasts (HGF)] by challenge of Porphyromonas gingivalis ( Pg ) with different fimA genotypes . Regulation HGF PLAT 10064822 593464 These results are consistent with the hypothesis that [HGF/SF] plays a role in the development and maintenance of both the cerebral cortex and hippocampus , and that may *act* as a regulator of HGF/SF activity in these structures . Regulation HGF PLAU 21709151 2455806 Furthermore , Mp expression of *regulated* the level of active [hepatocyte growth factor] , which is required for muscle fiber regeneration , in damaged muscle . Regulation HGF PLAU 7768515 308393 These findings imply that both and uPAR are *involved* in activating endogenous [HGF] in the regenerating livers of animals that underwent PHx . Regulation HGF TNF 11152574 758999 As [human gingival fibroblasts (HGF)] can be potential *targets* for in inflamed gingiva , we hypothesized that HGF partially modulate the cellular responses to TNF-alpha by regulating their own TNFR . Regulation HGF TNF 1384479 200559 and interferon-gamma but no other cytokine tested had slightly stimulatory *effects* on [HGF] production . Regulation HGF TNF 16006475 1459232 IL-6 and are *involved* in the production of [HGF] by endometrial stromal cells and may be involved in the growth of endometriosis by an autocrine mechanism . Regulation HGF TNF 16728464 1612356 Human progenitor cells from bone marrow or adipose tissue produce VEGF , [HGF] , and IGF-I in *response* to by a p38 MAPK dependent mechanism . Regulation HGF TNF 7593211 330318 Cultured follicular papilla cells secreted [HGF/SF] , measured by an enzyme linked immunoassay , in *response* to interleukin 1-alpha ( IL1-alpha , 10 ng/ml ) , ( TNF-alpha , 10 ng/ml ) , or tetradecanoylphorbolacetate ( 100 nM ) at levels ranging from 0.2 to 0.3 ng/mg protein/48 h. HGF/SF mRNA expressions , measured by the reverse transcription-polymerase chain reaction , were detected in follicular papilla cells , and were also stimulated by the three reagents . Regulation HGFAC SERPINA5 20402764 2246006 Hepatocyte growth factor activator ( [HGFA] ) : its *regulation* by . Regulation HIF1A EPHB2 19098317 2047618 *Role* of PI3K/Akt and in mediating hypoxia induced expression of [HIF-1alpha] and VEGF in laser induced rat choroidal neovascularization . Regulation HIF1A IL1B 12101082 962464 Inhibition of the mitochondrion complex I nicotinamide adenine dinucleotide phosphate dependent oxidase by diphenylene iodonium ( DPI ) , which blocks the conversion of ubiquinone -- > ubiquinol , abrogated *dependent* nuclear translocation and activation of [HIF-1 alpha] . Regulation HIF1A IL1B 12101082 962465 Similarly , interrupting the respiratory chain with potassium cyanide reversed the excitatory *effect* of on [HIF-1 alpha] nuclear translocation and activation . Regulation HIF1A MAP2K6 19098317 2047627 *Role* of PI3K/Akt and in mediating hypoxia induced expression of [HIF-1alpha] and VEGF in laser induced rat choroidal neovascularization . Regulation HIF1A MMP28 19558529 2149635 Impairment of ischaemia induced EPC mobilization in the diabetic mouse model is associated with altered [HIF-1 alpha/VEGF] and *regulation* and represents a novel mechanism underlying defective postischaemic neovascularization in diabetes . Regulation HIF1A MMP7 19558529 2149650 Impairment of ischaemia induced EPC mobilization in the diabetic mouse model is associated with altered [HIF-1 alpha/VEGF] and *regulation* and represents a novel mechanism underlying defective postischaemic neovascularization in diabetes . Regulation HIF1A TNF 11566189 863856 A non-hypoxic , ROS-sensitive pathway mediates *dependent* regulation of [HIF-1alpha] . Regulation HIF1A TNF 11566189 863858 A non-hypoxic , reactive oxygen species ( ROS ) -sensitive pathway mediating *dependent* regulation of [hypoxia-inducible factor-1alpha] ( HIF-alpha ) was investigated in vitro . Regulation HIF1A TNF 11566189 863862 Inhibition of the mitochondrion complex I abrogated *dependent* activation of [HIF-1alpha] . Regulation HIF1A TNF 11566189 863863 Interrupting the respiratory chain reversed the excitatory *effect* of on [HIF-1alpha] . Regulation HIF1A TNF 19744167 2147230 The aim of this study was to evaluate the *effects* of cobalt chloride ( CoCl ( 2 ) , a hypoxia mimicking agent ) , and toll-like receptor (TLR) -2 , -3 and -4 agonists on [HIF-1 alpha] accumulation , and further on HIF-1 alpha mediated modulation of mitochondrial respiration in cultured human hepatocytes . Regulation HIF1A TNF 19766100 2147416 Here , we provide evidence showing that IkappaB kinase beta (IKKbeta) is required for [HIF-1alpha] *regulation* by . Regulation HK1 FAS 10760476 683534 We investigated the *effect* of non esterified on bovine heart [hexokinase] ( type I : ATP : D-hexose 6-phosphotransferase , EC 2 .7.1.1 ) . Regulation HK1 HBEGF 11798972 892555 [ Autocrine *regulation* of [hexokinase] activity by in mesangial cells ] . Regulation HK1 RARRES1 19737656 2134591 The aim of this study was to explore the functional *role* of the protein ( alias TIG1 ) in NPC cells with EBV infection ( HK1-EBV ) and without ( [HK1] ) . Regulation HK2 ADRB2 24504055 2918691 *dependent* regulation of GLUT-1 and [HK-2] was determined by in vitro pharmacologic intervention . Regulation HK2 ADRB2 24504055 2918694 The expression of [HK-2] was *regulated* by the activation of in 4T1 breast cancer cells primarily at the posttranscriptional level . Regulation HK2 CTGF 18433544 1900208 To explore the *role* of exogenous in the collagen III synthesis of human renal tubular epithelial cell line [HK2] in vitro . Regulation HK2 FAS 10760476 683535 We investigated the *effect* of non esterified on bovine heart [hexokinase] ( type I : ATP : D-hexose 6-phosphotransferase , EC 2 .7.1.1 ) . Regulation HK2 HBEGF 11798972 892556 [ Autocrine *regulation* of [hexokinase] activity by in mesangial cells ] . Regulation HK2 INPP4B 24051093 2851805 Of the glycolysis-regulatory genes , [hexokinase 2 (HK2)] was mainly *regulated* by and this regulation was mediated through the Akt-mTOR pathway . Regulation HK3 FAS 10760476 683536 We investigated the *effect* of non esterified on bovine heart [hexokinase] ( type I : ATP : D-hexose 6-phosphotransferase , EC 2 .7.1.1 ) . Regulation HK3 HBEGF 11798972 892557 [ Autocrine *regulation* of [hexokinase] activity by in mesangial cells ] . Regulation HLA-A TNF 2493541 107983 These findings suggest that IFN alpha , IFN gamma , and may *play* similar roles in enhancement of [HLA-A] , B , C expression of hepatocytes in hepatitis and hepatoma cells . Regulation HLA-B TNF 14978666 1213584 The *effect* of blockade on the response to pneumococcal vaccination in patients with rheumatoid arthritis and [ankylosing spondylitis] . Regulation HLA-DRA IL1B 1628893 191837 Among those cytokines , had a positive *effect* on IFN-gamma dependent induction of [MHC class II] genes . Regulation HLA-DRA TNF 10415044 631165 The *effect* of on [MHC class II] expression depends on cell type and cellular differentiation state . Regulation HLA-DRA TNF 1979587 145146 We investigated the *effects* of recombinant human on cell proliferation and on expression of [MHC class II] antigens and intercellular adhesion molecule ICAM-1 in human dermal microvascular endothelial cells ( HDMEC ) derived from human foreskin . Regulation HLA-DRA TNF 20980264 2382332 induces macroautophagy and *regulates* [MHC class II] expression in human skeletal muscle cells . Regulation HLA-DRA TNF 20980264 2382336 The synergistic *effect* of and IFN-? on the induction of [MHC class II] surface expression was not reflected by higher intracellular human leukocyte antigen ( HLA ) -DR levels and was reversed by macroautophagy inhibition , suggesting that TNF-a facilitates antigen processing via macroautophagy for more efficient MHC class II loading . Regulation HLA-DRA TNF 20980264 2382340 These findings establish a mechanism through which *regulates* both macroautophagy and [MHC class II] expression and suggest that macroautophagy mediated antigen presentation contributes to the immunological environment of the inflamed human skeletal muscle . Regulation HLA-DRA TNF 2493382 107969 Schwann cells co-cultured with stimulated T cells and antigen express major histocompatibility complex ( MHC) class II determinants without interferon-gamma pretreatment : synergistic *effects* of interferon-gamma and on [MHC class II] induction . Regulation HLA-DRA TNF 3139431 97377 *Effects* of and interferon-beta (IFN-beta) on the IFN-gamma induced major histocompatibility complex ( [MHC) class II] expression on human umbilical vein endothelial ( HUVE ) cells are reported . Regulation HLA-DRA TNF 3139431 97393 The *role* of in the up-regulation as well as in the down-regulation of [MHC class II] expression in inflammatory processes is discussed . Regulation HLA-DRA TNF 7593465 336362 Isotype-specific *regulation* of [MHC class II] gene expression in human monocytes by exogenous and endogenous . Regulation HLA-DRB1 EPHB2 19786087 2209053 In addition , esculetin and HA14-1 mediated apoptosis was reduced by ERK inhibitors through inhibition of DR4 expression , suggesting that the synergistic effect was at least partially mediated through *dependent* induction of [DR4] expression . Regulation HLA-DRB1 EPHB2 19786087 2209055 The results indicate that HA14-1 induced reversal of the anti-apoptotic effect of Bcl-2 confers apoptosis sensitivity to esculetin by a mitochondrial amplification step and through the *dependent* induction of [DR4] expression in U937/Bcl-2 cells . Regulation HLA-DRB1 EPHB2 21817114 2490403 2-14 promoted *dependent* induction of [DR5] , thereby enhancing TRAIL mediated caspase-8 activation and apoptosis . Regulation HLA-DRB1 EPHB2 22848091 2682382 In addition , we discovered that the phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2 and RSK2 were elevated after PS-341 treatment and inhibition of their phosphorylation using MAP-ERK kinase 1/2 inhibitor decreased the DR5 level , indicating that signaling is *involved* in [DR5] upregulation . Regulation HLA-DRB1 EPHB2 23224239 2731477 Sub-toxic dose of apigenin sensitizes HepG2 cells to TRAIL through *dependent* up-regulation of TRAIL receptor [DR5] . Regulation HLA-DRB1 EPHB2 23224239 2731479 Next , using pharmacological inhibitors , we found that activation is *involved* in the induction of [DR5] expression . Regulation HLA-DRB1 IL1B 1628893 191839 Among those cytokines , had a positive *effect* on IFN-gamma dependent induction of [MHC class II] genes . Regulation HLA-DRB1 TNF 10415044 631166 The *effect* of on [MHC class II] expression depends on cell type and cellular differentiation state . Regulation HLA-DRB1 TNF 1979587 145147 We investigated the *effects* of recombinant human on cell proliferation and on expression of [MHC class II] antigens and intercellular adhesion molecule ICAM-1 in human dermal microvascular endothelial cells ( HDMEC ) derived from human foreskin . Regulation HLA-DRB1 TNF 20980264 2382333 induces macroautophagy and *regulates* [MHC class II] expression in human skeletal muscle cells . Regulation HLA-DRB1 TNF 20980264 2382337 The synergistic *effect* of and IFN-? on the induction of [MHC class II] surface expression was not reflected by higher intracellular human leukocyte antigen ( HLA ) -DR levels and was reversed by macroautophagy inhibition , suggesting that TNF-a facilitates antigen processing via macroautophagy for more efficient MHC class II loading . Regulation HLA-DRB1 TNF 20980264 2382341 These findings establish a mechanism through which *regulates* both macroautophagy and [MHC class II] expression and suggest that macroautophagy mediated antigen presentation contributes to the immunological environment of the inflamed human skeletal muscle . Regulation HLA-DRB1 TNF 2493382 107971 Schwann cells co-cultured with stimulated T cells and antigen express major histocompatibility complex ( MHC) class II determinants without interferon-gamma pretreatment : synergistic *effects* of interferon-gamma and on [MHC class II] induction . Regulation HLA-DRB1 TNF 3139431 97379 *Effects* of and interferon-beta (IFN-beta) on the IFN-gamma induced major histocompatibility complex ( [MHC) class II] expression on human umbilical vein endothelial ( HUVE ) cells are reported . Regulation HLA-DRB1 TNF 3139431 97394 The *role* of in the up-regulation as well as in the down-regulation of [MHC class II] expression in inflammatory processes is discussed . Regulation HLA-DRB1 TNF 7593465 336363 Isotype-specific *regulation* of [MHC class II] gene expression in human monocytes by exogenous and endogenous . Regulation HLA-DRB1 TNFSF10 11234890 789707 Reduced *effects* of in Bcr-Abl positive leukemic cells were not attributable to diminished expression of [DR4] and DR5 , or higher expressions of the decoy receptors DcR1 and -2 or c-FLIP ( L ) . Regulation HLA-DRB1 TNFSF10 15256461 1272142 Several lung cancer cell lines express [DR4] and DR5 and undergo apoptosis in vitro in *response* to . Regulation HLA-DRB1 TNFSF10 16462206 1522805 Our results provide the first evidence for the caveolar localization of TNF-R1 and [DR5] and the coordinated redistribution among membrane fractions of several death receptors in *response* to . Regulation HLA-DRB1 TNFSF10 18203008 1857501 In this review , we will discuss the mechanism of death receptor induced apoptosis and the *regulation* of [DR4] and DR5 expression . Regulation HLA-DRB1 TNFSF10 20886583 2332081 Taken together , these studies show that a-TEA induces TRAIL/DR5 mitochondria dependent apoptosis in human breast cancer cells , and that *dependent* increases in [DR5] and decreases in c-FLIP expression are triggered by TRAIL or a-TEA treatments . Regulation HLF CTGF 16141446 1499321 LXA4 inhibits these *effects* of on [HLF] . Regulation HLF TNF 1415727 201571 We studied the *effects* of transforming growth factor-beta ( TGF-beta ) and on fibrinolytic and procoagulant activities of [human lung fibroblasts (HLF)] to determine their capacity to regulate pulmonary fibrin deposition . Regulation HM13 SMN2 23897586 2916005 In contrast , no difference in IMP1 protein levels was detected in whole brain lysates from SMA mice , further suggesting neuron specific *roles* of in [IMP1] expression and localization . Regulation HMGA1 IL1B 9880529 583980 Therefore we investigated the *effect* of endotoxin and the cytokine on [HMG-I(Y)] expression in vascular smooth muscle cells . Regulation HMGB1 CD14 23508573 2787825 [HMGB1] induces the release of monocyte chemotactic protein 1 (MCP-1) , interferon gamma induced protein 10 ( IP-10 ) and macrophage inflammatory protein 1a ( MIP-1a ) in a TLR4- and *dependent* manner . Regulation HMGB1 EPHB2 21944254 2487911 [HMGB1] *regulates* autophagy through increasing transcriptional activities of JNK and in human myeloid leukemia cells . Regulation HMGB1 MAP2K6 21926646 2546852 The aim of this study was to explore the *role* of 6 ( MKK6 ) in the [HMGB1] expression in pulmonary alveolar epithelial cells induced by mechanical stretch . Regulation HMGB1 TNF 18582368 1941082 [HMGB1] is actively released from immune cells in *response* to ; Regulation HMOX1 ALOX5 24226420 2926624 Similar to 5-LO ( -/- ) mice , induction of [HO-1] , but not superoxide dismutase-2 (SOD-2) , was also observed in *response* to <5-LO> ( AA861 ) or 5-LO activating protein ( MK886 ) inhibitors . Regulation HMOX1 ARSA 18215658 1863968 The *effects* of <5-ASA> on the colonic expression and activity of [HO-1] along with its effect on the inflammatory damage have been evaluated in the colitis provoked by instillation of trinitrobenzene sulphonic acid ( TNBS ) over 48 h in the rat . Regulation HMOX1 EPHB2 12225959 987937 We also demonstrate that [HO-1] gene transcription after A-R *involves* , JNK , and p38 MAPK pathways . Regulation HMOX1 EPHB2 15993334 1429664 This suggests that is *involved* in the increase in [HO-1] through regulation of translation rather than transcription . Regulation HMOX1 EPHB2 18554677 1959060 Metallothionein-III protects against 6-hydroxydopamine induced oxidative stress by increasing expression of [heme oxygenase-1] in a PI3K and *dependent* manner . Regulation HMOX1 EPHB2 18554677 1959065 In this study , we demonstrate that MT-III prevents the accumulation of reactive oxygen species ( ROS ) in dopaminergic SH-SY5Y cells challenged with the Parkinson 's disease related neurotoxin 6-hydroxydopamine ( 6-OHDA ) by a mechanism that involves phosphatidylinositol 3-kinase (PI3K) and kinase/NF-E2 related factor 2 (Nrf2) *dependent* induction of the stress response protein [heme oxygenase-1 (HO-1)] . Regulation HMOX1 EPHB2 19201840 2033810 [HO-1] and CO inhibited LPS induced activation of the IFN regulatory factor 3 pathway and their effects were *independent* of p38 , , and JNK MAPK . Regulation HMOX1 EPHB2 19628634 2137826 Phosphorylation of and Nrf2 , activation and nuclear translocation of Nrf2 , and oxidation of Keap1 are all *involved* in the lansoprazole induced [HO-1] up-regulation . Regulation HMOX1 EPHB2 19822148 2159855 These results suggest that ( 1/2 ) and JNK are *involved* in CS-induced biphasic [HO-1] expression by a specific regulation of Nrf2/Keap1-Bach1 . Regulation HMOX1 EPHB2 20302373 2238035 Neurotrophic and cytoprotective action of luteolin in PC12 cells through *dependent* induction of Nrf2-driven [HO-1] expression . Regulation HMOX1 EPHB2 21366594 2415860 The H ( 2 ) O ( 2 ) -induced [HO-1] induction was Akt- and *dependent* . Regulation HMOX1 EPHB2 23261939 2763848 Akt and are *involved* in [HO-1] induction after oxidative stress . Regulation HMOX1 F2R 22541814 2669212 Pharmacologic inhibitors or activators and genetic inhibition by siRNA of protease activated receptors (PARs) revealed that the and PAR3 receptors , but not the PAR4 receptor , are *involved* in thrombin mediated upregulation of [HO-1] . Regulation HMOX1 GLP1R 20364157 2255301 *plays* a critical role in geniposide induced expression of [heme oxygenase-1] in PC12 cells . Regulation HMOX1 GLP1R 20364157 2255302 *plays* a critical role in geniposide induced [HO-1] expression to attenuate oxidative insults in PC12 cells . Regulation HMOX1 IL1B 7626076 316231 The *effect* of on [heme oxygenase-1] mRNA induction was slower ( maximal at 12 hrs ) and modest . Regulation HMOX1 IL1B 9751495 533560 An inhibitor of HO-1 activity , zinc-protoporphyrin IX ( ZnPP ) , prevented the protective effect of CoCl2 on insulin release with IL-1beta but did not affect [HO-1] expression or the inhibitory *response* to alone . Regulation HMOX1 TLR7 21677132 2451335 Bruton 's tyrosine kinase is required for *dependent* [heme oxygenase-1] gene activation via Nrf2 in macrophages . Regulation HMOX1 TNF 17883332 1818639 The effects of HO-1 transduction ( Ad-VECAD-HO-1 gene ) on [HO-1] expression , HO activity , and the *response* to and hyperglycemia were studied . Regulation HMOX1 TNF 18202225 1883780 Further investigation revealed that the cytoprotective gene [heme oxygenase-1 (HO-1)] was induced in NF-kappaB inhibited AML cells in *response* to stimulation , and HO-1 was responsible for the resistance of AML cells to the cytotoxic actions of TNF . Regulation HMOX1 TNF 18242889 1865002 In conclusion , reactive oxygen species ( ROS ) , rather than or nitric oxide ( NO ) , are *involved* in LPS induced upregulation of [HO-1] in fetal liver . Regulation HMOX1 TNF 21307400 2359998 Here we show for the first time that the modulatory protein , FLICE-inhibitory protein (FLIP) indirectly regulates induction of [HO-1] in *response* to in human AML blasts , but not non-cancerous control cells . Regulation HMOX1 TNF 9530200 496736 *Effect* of and interleukin-1 alpha on [heme oxygenase-1] expression in human endothelial cells . Regulation HMOX2 EDN2 9506613 491448 On the other hand , [HO-2] immunoreactivity was abundant in neurons and was not *affected* by , hemolysate , CO-hemolysate , or saline . Regulation HNF1A FOXA1 9685261 521693 *Regulation* of [HNF-4/HNF-1] expression by and HNF-3beta was studied in embryoid bodies in which one or both HNF-3alpha or HNF-3beta alleles were inactivated . Regulation HNF1A IL1B 11037876 741235 Neither nor Tau-Cl *affected* the activity of octamer [transcription factor 1] . Regulation HNF4A FOXA1 9685261 521695 *Regulation* of [HNF-4/HNF-1] expression by and HNF-3beta was studied in embryoid bodies in which one or both HNF-3alpha or HNF-3beta alleles were inactivated . Regulation HNF4A IL1B 16729332 1565789 A JNK-specific inhibitor blocked the inhibitory *effect* of on [HNF4 alpha] expression and CYP7A1 reporter activity . Regulation HNF4A PGC 12651943 1072810 *Regulation* of hepatic fasting response by : requirement for [hepatocyte nuclear factor 4alpha] in gluconeogenesis . Regulation HNRNPD IL1B 19454352 2084490 The known fungal pattern recognition receptors TLR2 and Dectin-1 regulate IL-1beta gene transcription , whereas the NLRP3 containing proinflammatory [multiprotein complex] , the NLRP3 inflammasome , *controls* caspase-1 mediated cleavage of . Regulation HNRNPF CCL17 22057112 2540300 The direct *effects* of on [DCs] and the indirect effects on differentiation of T helper ( Th ) cells were determined in vitro and ex vivo . Regulation HNRNPF CD14 9680340 521004 Cultures enriched in *dependent* [DCs] were more potent stimulators of a mixed leukocyte reaction , compared with control GTS cultures containing both types of DCs . Regulation HNRNPF CD14 9680340 521016 Although TNF is required to ensure the institution of DC hematopoiesis from CD34 ( + ) progenitor cells , its activity on a later progenitor appears to limit the development of *dependent* [DCs] . Regulation HNRNPF FAS 21297009 2420021 The decrease in the numbers of CD8 ( + ) [DCs] required iNKT cells but was *independent* of perforin , , or IFN-? , as it was observed in mice deficient in each of these molecules . Regulation HNRNPF ITGAL 20530790 2315694 Although LFA-1 ( lymphocyte function associated antigen 1 ) on T cells is considered to be important for antigen-specific T-cell activation , the *role* for on [DCs] remains elusive . Regulation HNRNPF ITGB2 19234188 2040165 Taken together , one of the mechanisms of Treg mediated suppression functions across species and mediates an *dependent* interaction between Tregs and [DCs] . Regulation HNRNPF ITGB2 23817428 2815798 Therefore , our results indicate that *dependent* interactions between T cells and [DCs] play a crucial role not only in supporting firm arrest during Ag recognition but also in facilitating the Ag scanning processes . Regulation HNRNPF MUC16 15944279 1416063 We have investigated whether a released by tumor cells could be *involved* in causing these immunomodulating effects on [DCs] . Regulation HNRNPF TLR7 16219795 1508138 Interleukin-12 (IL-12) is a heterodimeric cytokine produced by [dendritic cells (DCs)] in *response* to ligation . Regulation HNRNPF TLR7 17508961 1745127 Activation of TLRs by administration of specific bacterial ligands , in particular lipopolysaccharide , can augment airway sensitization in mice , and there is evidence that this process involves *dependent* activation of [DCs] . Regulation HNRNPF TLR7 17548596 1752189 Produced by [dendritic cells (DCs)] in *response* to ligands , IL-27 recently emerged as a key regulator of inflammatory responses . Regulation HNRNPF TLR7 17906627 1812464 Two specific and structurally different inhibitors of the MK Rsk suppressed TLR induced endocytosis , thus defining in [DCs] a specific requirement for MKs in *responses* . Regulation HNRNPF TLR7 18824534 1987766 Rather , it has been shown that helminth products such as soluble egg antigens ( SEA ; a soluble extract from Schistosoma mansoni eggs ) inhibit the activation of [DCs] in *response* to classical ligands such as lipopolysaccharide or CpG . Regulation HNRNPF TLR7 19836139 2196437 Additionally , saliva treated [DCs] also presented a similar pattern of cytokine modulation in *response* to other ligands . Regulation HNRNPF TLR7 20200270 2229551 In *response* to signaling , conventional [DCs] can also produce IFN-beta but not IFN-alpha in a type I IFN independent manner . Regulation HNRNPF TLR7 21690322 2455660 DCs are important primary targets of TSLP , and we unexpectedly demonstrated that [DCs] also produce TSLP in *response* to stimulation and that this is augmented by IL-4 . Regulation HNRNPF TLR7 23257360 2724808 Given the expansion of CD11c+ DCs during the progression of atherosclerosis and the key role of T cell activation in atherogenesis , we sought to understand the *role* of signaling in CD11c+ [DCs] in atherosclerosis . Regulation HNRNPF TNF 12822512 1104256 Because TNF-alpha has been shown to induce the activation and maturation of dendritic cells (DCs) , we investigated the *effect* of secreted by transduced cells ( 32DTNF-alpha cells ) on the activation of [DCs] and their role in the production of antileukemic cytotoxic T lymphocytes ( CTLs ) . Regulation HNRNPF TNF 8542932 338767 We show that the *dependent* ex vivo generation of [DCs] from mobilized CD34+ cells is 2.5-fold enhanced by flk-2/flt-3 ligand or c-kit ligand ( stem cell factor ) and five-fold enhanced by a combination of these growth factors . Regulation HNRNPH1 CCL17 22057112 2540301 The direct *effects* of on [DCs] and the indirect effects on differentiation of T helper ( Th ) cells were determined in vitro and ex vivo . Regulation HNRNPH1 CD14 9680340 521005 Cultures enriched in *dependent* [DCs] were more potent stimulators of a mixed leukocyte reaction , compared with control GTS cultures containing both types of DCs . Regulation HNRNPH1 CD14 9680340 521017 Although TNF is required to ensure the institution of DC hematopoiesis from CD34 ( + ) progenitor cells , its activity on a later progenitor appears to limit the development of *dependent* [DCs] . Regulation HNRNPH1 FAS 21297009 2420022 The decrease in the numbers of CD8 ( + ) [DCs] required iNKT cells but was *independent* of perforin , , or IFN-? , as it was observed in mice deficient in each of these molecules . Regulation HNRNPH1 ITGAL 20530790 2315695 Although LFA-1 ( lymphocyte function associated antigen 1 ) on T cells is considered to be important for antigen-specific T-cell activation , the *role* for on [DCs] remains elusive . Regulation HNRNPH1 ITGB2 19234188 2040167 Taken together , one of the mechanisms of Treg mediated suppression functions across species and mediates an *dependent* interaction between Tregs and [DCs] . Regulation HNRNPH1 ITGB2 23817428 2815800 Therefore , our results indicate that *dependent* interactions between T cells and [DCs] play a crucial role not only in supporting firm arrest during Ag recognition but also in facilitating the Ag scanning processes . Regulation HNRNPH1 MUC16 15944279 1416078 We have investigated whether a released by tumor cells could be *involved* in causing these immunomodulating effects on [DCs] . Regulation HNRNPH1 TLR7 16219795 1508148 Interleukin-12 (IL-12) is a heterodimeric cytokine produced by [dendritic cells (DCs)] in *response* to ligation . Regulation HNRNPH1 TLR7 17508961 1745137 Activation of TLRs by administration of specific bacterial ligands , in particular lipopolysaccharide , can augment airway sensitization in mice , and there is evidence that this process involves *dependent* activation of [DCs] . Regulation HNRNPH1 TLR7 17548596 1752199 Produced by [dendritic cells (DCs)] in *response* to ligands , IL-27 recently emerged as a key regulator of inflammatory responses . Regulation HNRNPH1 TLR7 17906627 1812474 Two specific and structurally different inhibitors of the MK Rsk suppressed TLR induced endocytosis , thus defining in [DCs] a specific requirement for MKs in *responses* . Regulation HNRNPH1 TLR7 18824534 1987776 Rather , it has been shown that helminth products such as soluble egg antigens ( SEA ; a soluble extract from Schistosoma mansoni eggs ) inhibit the activation of [DCs] in *response* to classical ligands such as lipopolysaccharide or CpG . Regulation HNRNPH1 TLR7 19836139 2196447 Additionally , saliva treated [DCs] also presented a similar pattern of cytokine modulation in *response* to other ligands . Regulation HNRNPH1 TLR7 20200270 2229552 In *response* to signaling , conventional [DCs] can also produce IFN-beta but not IFN-alpha in a type I IFN independent manner . Regulation HNRNPH1 TLR7 21690322 2455670 DCs are important primary targets of TSLP , and we unexpectedly demonstrated that [DCs] also produce TSLP in *response* to stimulation and that this is augmented by IL-4 . Regulation HNRNPH1 TLR7 23257360 2724818 Given the expansion of CD11c+ DCs during the progression of atherosclerosis and the key role of T cell activation in atherogenesis , we sought to understand the *role* of signaling in CD11c+ [DCs] in atherosclerosis . Regulation HNRNPH1 TNF 12822512 1104257 Because TNF-alpha has been shown to induce the activation and maturation of dendritic cells (DCs) , we investigated the *effect* of secreted by transduced cells ( 32DTNF-alpha cells ) on the activation of [DCs] and their role in the production of antileukemic cytotoxic T lymphocytes ( CTLs ) . Regulation HNRNPH1 TNF 8542932 338769 We show that the *dependent* ex vivo generation of [DCs] from mobilized CD34+ cells is 2.5-fold enhanced by flk-2/flt-3 ligand or c-kit ligand ( stem cell factor ) and five-fold enhanced by a combination of these growth factors . Regulation HNRNPK EPHB2 11231586 789600 Our results establish the *role* of in phosphorylation dependent cellular localization of [hnRNP-K] , which is required for its ability to silence mRNA translation . Regulation HNRNPK EPHB2 19880579 2165787 Our data showed a clear *dependent* increase in one form of [hnRNP-K] after TCR stimulation . Regulation HOMER1 EPHB2 24167026 2889717 These data indicate that [Homer1c-mGluR5] interactions are necessary for mGluR dependent LTP , and that mGluR1/5 dependent LTP *involves* PI3K and activation . Regulation HOXA1 NR2F1 23018522 2720235 Moreover , analysis of the expression of primary RA response genes indicates that is *involved* in the regulatory modulation of the expression of at least two genes , CYP26A1 and [HoxA1] . Regulation HOXA10 HBEGF 17828513 1795617 Regulatory *effect* of estrogen , progestin and on the expression of [HOXA10] gene in Ishikawa cells . Regulation HOXA10 IL1B 16551735 1568216 Thrombin and *regulate* [HOXA10] expression in human term decidual cells : implications for preterm labor . Regulation HOXA9 TNF 17452460 1743130 Moreover , we showed that [HOXA9] binds temporally , in a *dependent* manner , to the region containing this Abd-B-like element in vivo . Regulation HOXB13 FOXA1 20018680 2191698 These data demonstrate that directly *regulates* [HOXB13] in human prostate epithelial cells , and show that this prostate-specific regulatory mechanism is conserved in mice . Regulation HOXB2 ALX3 11518511 851654 Our results are consistent with a model in which defects in ventral body wall formation require the simultaneous loss of at least [Hoxb2] and Hoxb4 , and may *involve* and Alx4 . Regulation HOXB2 ALX4 11518511 851655 Our results are consistent with a model in which defects in ventral body wall formation require the simultaneous loss of at least [Hoxb2] and Hoxb4 , and may *involve* Alx3 and . Regulation HOXB2 EGR2 11336508 812022 Differences in dependent *regulation* of Hoxa2 and [Hoxb2] during hindbrain development . Regulation HOXB2 EGR2 8093858 210085 The zinc finger gene *regulates* [HoxB2] ( Hox2.8 ) during hindbrain segmentation . Regulation HOXB2 EGR2 9256343 447947 We have previously demonstrated that in r3 and r5 directly *controls* the transcription of Hoxa-2 and [Hoxb-2] . Regulation HOXB2 GATA1 7876223 298550 Transcription factor *regulates* human [HOXB2] gene expression in erythroid cells . Regulation HOXB2 PREP 17875935 1818352 p160 and Pbx1 compete for Prep1 in vitro , and p160 inhibits *dependent* [HoxB2] expression in retinoic acid treated NT2-D1 cells . Regulation HP TNF 10229868 611194 TNF induced [haptoglobin] release from human neutrophils : pivotal *role* of the p55 receptor . Regulation HP TNF 7492636 335542 To explore possible regulatory factors unique to ruminants , we examined *effects* of interleukin (IL)-6 , IL-1 and , on [haptoglobin (Hp)] synthesis using a primary culture system of bovine hepatocytes . Regulation HPGD TNF 16195422 1507790 Because of the importance of TNF-alpha in IBD , we also determined the *effects* of on the expression of [15-PGDH] in vitro . Regulation HPR RARB 10328240 612931 Our results demonstrate that basal expression and 4HPR inducibility of *play* a role in mediating [4HPR] response in ovarian cancer cells . Regulation HPS1 CD14 9169763 432887 Binding to monocytes was enhanced by [human pooled serum (HPS)] or LPS binding protein (LBP) for LPS concentrations up to 100 ng/ml and was completely *dependent* . Regulation HPS1 TNF 22672643 2611307 This study is to neutralize TNF-a with specific monoclonal antibody to TNF-a ( TNF-a McAb ) to investigate the *effect* of on [HPS] . Regulation HRAS AXIN2 17374607 1734759 The [Ras] *regulation* by was blocked by treatment of leupeptin , an inhibitor of the lysosomal protein degradation machinery . Regulation HRAS EPHB2 10978313 751959 Whereas the essential *roles* of and JNK in [Ras] signaling has been established , the contribution of p38 remains unclear . Regulation HRAS EPHB2 17724343 1789855 Subcellular compartmentalization has become an important theme in cell signaling such as spatial *regulation* of [Ras] by RasGRP1 and by Sef . Regulation HRAS EPHB2 17873330 1796091 The aim of this work is to evaluate if [Ras] can be induced by TSH in rat thyroids , and whether may be *involved* in the subsequent intracellular signalling cascade . Regulation HRAS EPHB2 20392691 2273724 The promoter of the Nol3 locus , encoding ARC , is activated by N-Ras and [H-Ras] in a *dependent* manner . Regulation HRAS EPHB2 21277645 2457908 Furthermore , , a critical growth *regulator* downstream of [RAS] , may play a role . Regulation HRAS EPHB2 23153539 2699904 RAF inhibitors potently inhibit RAF monomers and ERK signaling , causing relief of *dependent* feedback , reactivation of ligand dependent signal transduction , increased [Ras-GTP] , and generation of RAF-inhibitor-resistant RAF dimers . Regulation HRAS FAS 20418879 2262477 Small-molecule inhibition of *affects* [Ras] localization and signaling . Regulation HRAS FHL1 23456229 2781827 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Regulation HRAS GPR115 14656216 1176899 Role of receptor tyrosine kinases in *regulation* of [Ras] : transactivation or parallel pathways ? Regulation HRAS GPR132 14656216 1176888 Role of receptor tyrosine kinases in *regulation* of [Ras] : transactivation or parallel pathways ? Regulation HRAS GPR87 14656216 1176968 Role of receptor tyrosine kinases in *regulation* of [Ras] : transactivation or parallel pathways ? Regulation HRAS MAP2K6 17724343 1789861 Subcellular compartmentalization has become an important theme in cell signaling such as spatial *regulation* of [Ras] by RasGRP1 and by Sef . Regulation HRAS MAP2K6 20392691 2273730 The promoter of the Nol3 locus , encoding ARC , is activated by N-Ras and [H-Ras] in a *dependent* manner . Regulation HRH1 CA2 7980641 281376 The enhancement of [histamine H1-receptor] *responses* by DTT was reversed by the sulphydryl oxidizing agent dithiobis- ( 2-nitrobenzoic acid ) . Regulation HRH1 CDC73 10482285 643812 *Effects* of on [histamine H1 receptor] mRNA expression in rat trigeminal ganglia . Regulation HRH1 CTR9 10482285 643813 *Effects* of on [histamine H1 receptor] mRNA expression in rat trigeminal ganglia . Regulation HRH1 IL1B 11282781 799256 In our study , indomethacin a cox antagonist , completely inhibited the *effect* of on [H(1)R] , whereas exogenously added PGE ( 2 ) was able to desensitize H(1)R . Regulation HRH1 LEO1 10482285 643816 *Effects* of on [histamine H1 receptor] mRNA expression in rat trigeminal ganglia . Regulation HRH1 PAF1 10482285 643814 *Effects* of on [histamine H1 receptor] mRNA expression in rat trigeminal ganglia . Regulation HRH1 VDR 17547532 1784219 RT-PCR , electromotility shift , siRNA inhibition assays , and chromatin immunoprecipitation assays were used to analyze the *role* of in activation of DPT and [HRH1] during differentiation . Regulation HRH1 WDR61 10482285 643815 *Effects* of on [histamine H1 receptor] mRNA expression in rat trigeminal ganglia . Regulation HSD11B2 AKT1 18032797 1852115 It was found that CCAAT/enhancer binding protein-alpha ( C/EBP-alpha ) and C/EBP-beta regulated HSD11B2 transcription and that DHEA likely modulated the transcription of [11beta-HSD2] in a phosphatidylinositol-3 *dependent* manner by increasing C/EBP-beta mRNA and protein expression . Regulation HSD11B2 AKT2 18032797 1852116 It was found that CCAAT/enhancer binding protein-alpha ( C/EBP-alpha ) and C/EBP-beta regulated HSD11B2 transcription and that DHEA likely modulated the transcription of [11beta-HSD2] in a phosphatidylinositol-3 *dependent* manner by increasing C/EBP-beta mRNA and protein expression . Regulation HSD11B2 AKT3 18032797 1852117 It was found that CCAAT/enhancer binding protein-alpha ( C/EBP-alpha ) and C/EBP-beta regulated HSD11B2 transcription and that DHEA likely modulated the transcription of [11beta-HSD2] in a phosphatidylinositol-3 *dependent* manner by increasing C/EBP-beta mRNA and protein expression . Regulation HSD11B2 ANGPT2 12911547 1122119 Therefore , we hypothesized that *regulates* [11beta-HSD2] . Regulation HSD11B2 CEBPA 17951535 1814504 In conclusion , we demonstrated that GR and were *involved* in cortisol induced [11beta-HSD1] mRNA expression via binding to 11beta-HSD1 promoter in amnion fibroblasts , which may cast a feed-forward production of cortisol in the fetal membranes at the end of gestation . Regulation HSD11B2 CEBPA 18032797 1852113 It was found that ( C/EBP-alpha ) and C/EBP-beta *regulated* [HSD11B2] transcription and that DHEA likely modulated the transcription of 11beta-HSD2 in a phosphatidylinositol-3 kinase/Akt dependent manner by increasing C/EBP-beta mRNA and protein expression . Regulation HSD11B2 CEBPA 18032797 1852122 Moreover , it is shown that and C/EBP-beta differentially *regulate* the expression of [11beta-HSD1] and 11beta-HSD2 . Regulation HSD11B2 CEBPB 18032797 1852114 It was found that CCAAT/enhancer binding protein-alpha ( C/EBP-alpha ) and *regulated* [HSD11B2] transcription and that DHEA likely modulated the transcription of 11beta-HSD2 in a phosphatidylinositol-3 kinase/Akt dependent manner by increasing C/EBP-beta mRNA and protein expression . Regulation HSD11B2 CEBPB 18032797 1852123 Moreover , it is shown that C/EBP-alpha and differentially *regulate* the expression of 11beta-HSD1 and [11beta-HSD2] . Regulation HSD11B2 CRH 12519881 1047753 Neither nor ACTH *affected* [11 beta-HSD-1] mRNA expression . Regulation HSD11B2 EPHB2 12626438 1079884 Overexpression of Egr-1 reduced endogenous 11beta-HSD2 activity in LLC-PK1 cells , indicating that MAPK is *involved* in the regulation of [11beta-HSD2] in vitro . Regulation HSD11B2 GCA 10624835 658495 In the present study , various steroid hormones or , given for 1 week , or thyroxine given for 5 weeks to normal intact rats had different *effects* on the [11beta-HSD] oxidative activity in testis and liver . Regulation HSD11B2 GH1 9217293 442060 To investigate the *effects* of on [11beta-HSD1] , we determined changes in hepatic 11beta-HSD1 activity in hypothyroid rats following treatment with subcutaneous ( s.c ) injection of GH for periods ranging from 24 h to 7 days . Regulation HSD11B2 HRAS 10026096 591189 To examine the hypothesis that nutritional signals regulate the expression of 11beta-HSD2 in placental syncytiotrophoblasts , we investigated the *effects* of , the major metabolites of vitamin A , on the expression of [11beta-HSD2] using human choriocarcinoma JEG-3 cells as a model . Regulation HSD11B2 HSD17B1 15358559 1293518 In particular , 11beta-hydroxysteroid dehydrogenase-type 1 ( 11beta-HSD1 ) and [11beta-HSD2] regulate the levels of glucocorticoids , such as cortisol , and <17beta-HSD1> and 17beta-HSD2 *regulate* the levels of androgens and estrogens . Regulation HSD11B2 HSD17B2 15358559 1293519 In particular , 11beta-hydroxysteroid dehydrogenase-type 1 ( 11beta-HSD1 ) and [11beta-HSD2] regulate the levels of glucocorticoids , such as cortisol , and 17beta-HSD1 and <17beta-HSD2> *regulate* the levels of androgens and estrogens . Regulation HSD11B2 IGF1 10566668 567491 Neither nor GH had any *effect* on [11betaHSD2] activity . Regulation HSD11B2 IGF1 8713094 373598 In 2S FAZA cells [11 beta-HSD] 1 activity and mRNA expression are *regulated* by hormones , with dexamethasone increasing activity and insulin , forskolin and decreasing it . Regulation HSD11B2 IGF2 19394351 2100772 Mechanistic examination of gene expression in embryonic day 12 placentas found that early PNS was associated with increased expression and sex dependent *effects* of stress on [11 beta-HSD2] , supporting specific aspects of early pregnancy . Regulation HSD11B2 IL1B 15979541 1424657 Therefore , we have evaluated the *effect* of tumor necrosis factor-alpha (TNF-alpha) and on [11beta-HSD2] in cultured human placental trophoblast and in human choriocarcinoma JEG-3 cells . Regulation HSD11B2 IL1B 18840637 2012917 We examined the expression of [11beta-HSD1] and its *regulation* by cortisol and in human fetal lung . Regulation HSD11B2 INS 10775808 686712 The present study was designed to examine the *effects* of on [11beta-HSD1] expression in human adipose stromal cells under basal and TNFalpha stimulated conditions . Regulation HSD11B2 INS 10775808 686714 Northern blot analysis revealed corresponding changes in the level of 11beta-HSD1 mRNA , suggesting that the *effects* of TNFalpha and on [11beta-HSD1] activity are mediated at the level of gene transcription . Regulation HSD11B2 INS 11786677 891797 As assessed by urinary free cortisol/urinary free cortisone ratios and endorsed through in vitro studies , neither GH nor *affect* [11beta-HSD2] activity . Regulation HSD11B2 INS 7588203 329802 Glucocorticoid and *regulation* of hepatic [11 beta HSD-1] is directly mediated , but other hormonal controls are either lost in culture or mediated indirectly . Regulation HSD11B2 KRAS 10026096 591190 To examine the hypothesis that nutritional signals regulate the expression of 11beta-HSD2 in placental syncytiotrophoblasts , we investigated the *effects* of , the major metabolites of vitamin A , on the expression of [11beta-HSD2] using human choriocarcinoma JEG-3 cells as a model . Regulation HSD11B2 LEP 12765951 1094138 In contrast , leptin did not influence 11beta-HSD1 expression in primary hepatocytes from db/db mice , indicating that *regulation* of [11beta-HSD1] expression is probably mediated by the functional leptin receptor . Regulation HSD11B2 MAPK1 19088256 2024395 To our knowledge , this is the first study showing *involvement* of p38 in the TNF-alpha mediated [11beta-HSD1] regulation , and that TNF-alpha stimulates enzyme activity in vivo . Regulation HSD11B2 MAPK1 19497972 2120624 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Regulation HSD11B2 MAPK10 19088256 2024396 To our knowledge , this is the first study showing *involvement* of p38 in the TNF-alpha mediated [11beta-HSD1] regulation , and that TNF-alpha stimulates enzyme activity in vivo . Regulation HSD11B2 MAPK10 19497972 2120625 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Regulation HSD11B2 MAPK11 19088256 2024397 To our knowledge , this is the first study showing *involvement* of p38 in the TNF-alpha mediated [11beta-HSD1] regulation , and that TNF-alpha stimulates enzyme activity in vivo . Regulation HSD11B2 MAPK11 19497972 2120626 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Regulation HSD11B2 MAPK12 19088256 2024398 To our knowledge , this is the first study showing *involvement* of p38 in the TNF-alpha mediated [11beta-HSD1] regulation , and that TNF-alpha stimulates enzyme activity in vivo . Regulation HSD11B2 MAPK12 19497972 2120627 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Regulation HSD11B2 MAPK13 19088256 2024399 To our knowledge , this is the first study showing *involvement* of p38 in the TNF-alpha mediated [11beta-HSD1] regulation , and that TNF-alpha stimulates enzyme activity in vivo . Regulation HSD11B2 MAPK13 19497972 2120628 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Regulation HSD11B2 MAPK14 19088256 2024400 To our knowledge , this is the first study showing *involvement* of p38 in the TNF-alpha mediated [11beta-HSD1] regulation , and that TNF-alpha stimulates enzyme activity in vivo . Regulation HSD11B2 MAPK14 19497972 2120629 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Regulation HSD11B2 MAPK15 19088256 2024394 To our knowledge , this is the first study showing *involvement* of p38 in the TNF-alpha mediated [11beta-HSD1] regulation , and that TNF-alpha stimulates enzyme activity in vivo . Regulation HSD11B2 MAPK15 19497972 2120623 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Regulation HSD11B2 MAPK3 19088256 2024401 To our knowledge , this is the first study showing *involvement* of p38 in the TNF-alpha mediated [11beta-HSD1] regulation , and that TNF-alpha stimulates enzyme activity in vivo . Regulation HSD11B2 MAPK3 19497972 2120630 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Regulation HSD11B2 MAPK3 23966319 2850443 Furthermore , U0126 increased the HSD11B2 promoter activity by 300 % , indicating that *regulates* placental [11beta-HSD2] expression through a transcriptional mechanism . Regulation HSD11B2 MAPK4 19088256 2024402 To our knowledge , this is the first study showing *involvement* of p38 in the TNF-alpha mediated [11beta-HSD1] regulation , and that TNF-alpha stimulates enzyme activity in vivo . Regulation HSD11B2 MAPK4 19497972 2120631 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Regulation HSD11B2 MAPK6 19088256 2024403 To our knowledge , this is the first study showing *involvement* of p38 in the TNF-alpha mediated [11beta-HSD1] regulation , and that TNF-alpha stimulates enzyme activity in vivo . Regulation HSD11B2 MAPK6 19497972 2120632 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Regulation HSD11B2 MAPK7 19088256 2024404 To our knowledge , this is the first study showing *involvement* of p38 in the TNF-alpha mediated [11beta-HSD1] regulation , and that TNF-alpha stimulates enzyme activity in vivo . Regulation HSD11B2 MAPK7 19497972 2120633 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Regulation HSD11B2 MAPK8 19088256 2024405 To our knowledge , this is the first study showing *involvement* of p38 in the TNF-alpha mediated [11beta-HSD1] regulation , and that TNF-alpha stimulates enzyme activity in vivo . Regulation HSD11B2 MAPK8 19497972 2120634 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Regulation HSD11B2 MAPK9 19088256 2024406 To our knowledge , this is the first study showing *involvement* of p38 in the TNF-alpha mediated [11beta-HSD1] regulation , and that TNF-alpha stimulates enzyme activity in vivo . Regulation HSD11B2 MAPK9 19497972 2120635 In addition , SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity , indicating that p38 *regulates* placental [11beta-HSD2] expression through modulation of 11beta-HSD2 mRNA stability . Regulation HSD11B2 NRAS 10026096 591191 To examine the hypothesis that nutritional signals regulate the expression of 11beta-HSD2 in placental syncytiotrophoblasts , we investigated the *effects* of , the major metabolites of vitamin A , on the expression of [11beta-HSD2] using human choriocarcinoma JEG-3 cells as a model . Regulation HSD11B2 PIK3CA 18032797 1852118 It was found that CCAAT/enhancer binding protein-alpha ( C/EBP-alpha ) and C/EBP-beta regulated HSD11B2 transcription and that DHEA likely modulated the transcription of [11beta-HSD2] in a *dependent* manner by increasing C/EBP-beta mRNA and protein expression . Regulation HSD11B2 PIK3R1 18032797 1852119 It was found that CCAAT/enhancer binding protein-alpha ( C/EBP-alpha ) and C/EBP-beta regulated HSD11B2 transcription and that DHEA likely modulated the transcription of [11beta-HSD2] in a *dependent* manner by increasing C/EBP-beta mRNA and protein expression . Regulation HSD11B2 PRKACB 16872738 1600681 In the present study we show that [HSD11B2] expression in human renal epithelial P58 cells is regulated at the mRNA and protein level , and that and C ( PKC ) are *involved* in this process . Regulation HSD11B2 PRKACG 16872738 1600682 In the present study we show that [HSD11B2] expression in human renal epithelial P58 cells is regulated at the mRNA and protein level , and that and C ( PKC ) are *involved* in this process . Regulation HSD11B2 PRKAR1A 16872738 1600683 In the present study we show that [HSD11B2] expression in human renal epithelial P58 cells is regulated at the mRNA and protein level , and that and C ( PKC ) are *involved* in this process . Regulation HSD11B2 PRKAR1B 16872738 1600684 In the present study we show that [HSD11B2] expression in human renal epithelial P58 cells is regulated at the mRNA and protein level , and that and C ( PKC ) are *involved* in this process . Regulation HSD11B2 PRKAR2A 16872738 1600685 In the present study we show that [HSD11B2] expression in human renal epithelial P58 cells is regulated at the mRNA and protein level , and that and C ( PKC ) are *involved* in this process . Regulation HSD11B2 PRKAR2B 16872738 1600686 In the present study we show that [HSD11B2] expression in human renal epithelial P58 cells is regulated at the mRNA and protein level , and that and C ( PKC ) are *involved* in this process . Regulation HSD11B2 PTGS2 15718388 1402866 These data indicate that plays a modulating role in the development of hypertension due to 11betaHSD2 deficiency and that [11betaHSD2] *regulates* renal COX-2 expression by preventing glucocorticoid access to MRs during postnatal development . Regulation HSD11B2 TNF 10775808 686713 Northern blot analysis revealed corresponding changes in the level of 11beta-HSD1 mRNA , suggesting that the *effects* of and insulin on [11beta-HSD1] activity are mediated at the level of gene transcription . Regulation HSD11B2 TNF 11696370 877500 The *effect* of on [11beta-HSD2] was reversed by inhibiting the mitogen activated protein kinases ERK with PD-098050 and p38 by SB-202190 , or by activating protein kinase A with forskolin . Regulation HSD11B2 TNF 15659537 1381937 The analysis of the transcriptional *regulation* of [11beta-HSD2] by and phorbol 12-myristate-13-acetate ( PMA ) with in vivo genomic footprinting in human colon SW620 cells revealed stimulus dependent protein-DNA interactions in three promoter regions , kappaB1 , Sp1/Egr-1I , and Sp1/Egr-1II . Regulation HSD11B2 TNF 15979541 1424656 Therefore , we have evaluated the *effect* of and interleukin-1beta (IL-1beta) on [11beta-HSD2] in cultured human placental trophoblast and in human choriocarcinoma JEG-3 cells . Regulation HSD11B2 TNF 19088256 2024393 To our knowledge , this is the first study showing involvement of p38 MAPK in the mediated [11beta-HSD1] *regulation* , and that TNF-alpha stimulates enzyme activity in vivo . Regulation HSD17B1 HSD11B2 15358559 1293520 In particular , 11beta-hydroxysteroid dehydrogenase-type 1 ( 11beta-HSD1 ) and <11beta-HSD2> regulate the levels of glucocorticoids , such as cortisol , and [17beta-HSD1] and 17beta-HSD2 *regulate* the levels of androgens and estrogens . Regulation HSD17B1 IL1B 8003440 257889 In this investigation we have examined the *effect* of TNF alpha , and IL-6 on [E2DH] activity in MCF-7 breast cancer cells . Regulation HSD17B11 SP1 21549806 2440465 These results show that [HSD17B11] transcription in PC cells is *regulated* by and C/EBPa . Regulation HSD17B2 HSD11B2 15358559 1293521 In particular , 11beta-hydroxysteroid dehydrogenase-type 1 ( 11beta-HSD1 ) and <11beta-HSD2> regulate the levels of glucocorticoids , such as cortisol , and 17beta-HSD1 and [17beta-HSD2] *regulate* the levels of androgens and estrogens . Regulation HSF1 FAS 10224227 610080 These *effects* of activation on the [HSF1/hsp70] stress response were blocked by ICE ( caspase 1 ) inhibitors , suggesting an ICE mediated process . Regulation HSF1 FAS 10897390 711856 These *effects* of on the [HSF1/hsp70] stress response were blocked by ICE ( caspase 1 ) -inhibitors , suggesting an ICE mediated process . Regulation HSF2 TNF 2483767 103990 One set of acute phase proteins , including alpha 2-macroglobulin , alpha 1-antichymotrypsin ( = contrapsin ) , cysteine protease inhibitor ( = thiostatin ) , alpha 1-antitrypsin , ceruloplasmin and fibrinogens are predominantly *regulated* by the keratinocyte derived [HSF-III/-II] or IL-6 , while a second set of proteins , including alpha 1-acid glycoprotein ( AGP ) , haptoglobin and complement C3 are predominantly regulated by keratinocyte derived HSF-I , IL-1 or . Regulation HSF4 EPHB2 16581800 1543961 While activated ERK phosphorylates [Hsf4b] , DUSP26 *controls* the activity of , leading to phosphorylation/dephosphorylation of Hsf4b , altering its ability to bind DNA . Regulation HSP90AA1 EPHB2 15360086 1293611 The [Hsp90] chaperone complex inhibitor , radicicol , potentiated heat induced cellular killing , and inhibition of p42/p44 and Akt activation rather than modification of Hsp expression might be *involved* in enhancing cellular thermosensitivity . Regulation HSP90AA1 IFI27 14612944 1163390 In this study , using the recombinant adenoviral vector expressing p27KIP1 ( Adp27KIP1 ) , we investigated whether *affects* [telomerase] activity in malignant glioma U373-MG cells . Regulation HSP90AB1 CAPN8 12824289 1113598 Immunoprecipitation studies revealed that glucose induces loss of NO via a *dependent* decrease in the association of [hsp90] with endothelial nitric oxide synthase . Regulation HSP90B1 CAPN8 16920763 1626772 THAPS at 5 microM significantly induced GRP94 , while 20 mmicroM caused a *dependent* cleavage of [GRP94] . Regulation HSPA5 CD14 14516777 1147171 *dependent* regulation of [Grp78] in the liver and lungs of mice after burn injury . Regulation HSPA5 CD14 14516777 1147173 These data demonstrate *dependent* and tissue-specific regulation of the [Grp78] expression after burn injury . Regulation HSPA5 FOXO1 22422508 2643044 Neither forced expression of nor knockdown of FOXO1 in R- cells *affected* [GRP78] expression . Regulation HSPA5 TNF 20650266 2340538 In contrast , IFN-? or had no *effect* on [Grp78] expression . Regulation HSPB1 EPHB2 21530534 2435210 In this study , we investigated Hsp27 and phospho-Hsp27 expression during morphine dependence and withdrawal and evaluated the *involvement* of in the phosphorylation of [Hsp27] in the rat right ventricle . Regulation HSPB1 TNF 1647957 160540 In view of the rapidity of the *effect* of on the phosphorylation of [HSP27] , it seems likely that the observed hyporesponsiveness reflects impairment of an early step in a signaling pathway , perhaps common to both the stimulation of phosphorylation and the induction of cell death by TNF . Regulation HSPB3 ANKRD1 21730198 2471517 The carboxyl-terminal of AKR2A was *responsible* for AKR2A binding to [Hsp17] .8 . Regulation HSPB3 TNF 11889017 920117 *regulates* insulin-like growth factor-1 and insulin-like growth factor binding [protein-3] expression in vascular smooth muscle . Regulation HSPD1 CD14 11705907 879482 The M. tuberculosis Cpn 60 .2 protein activates human peripheral blood mononuclear cells by a CD14 independent mechanism , whereas [Cpn 60] .1 is partially *dependent* and contains a peptide sequence whose actions are blocked by anti-CD14 monoclonal antibodies . Regulation HSPE1 TNF 18096563 1869115 The aim of the present study was to investigate if [endometriotic peritoneal fluids (EPF)] could interfere with endometrial stromal cell ( ESC ) decidualization and if could be *involved* in the EPF effect . Regulation HSPG2 ANGPT1 15920022 1420476 had no *effect* on [PLC] phosphorylation and IP3 production , thus its permeability decreasing effect could not be ascribed to inhibition of PLC activation . Regulation HSPG2 CAPN8 2297226 127597 We examined the question of whether was *involved* in the observed [PLC] activation by thrombin and trypsin . Regulation HSPG2 EPHB2 19747075 2168251 These data suggest that the mitogenic effect of CMS2MS2 on fibroblasts is independent of its proteolytic activity , requires phosphorylation , and *involves* activation of [PLC] . Regulation HSPG2 IL1B 17959727 1830826 Knockdown of RGS4 by siRNA in both muscle strips and cultured muscle cells blocked the inhibitory *effect* of on initial contraction and [PLC-beta] activation , whereas overexpression of RGS4 inhibited PLC-beta activation . Regulation HSPG2 TNF 10030839 591865 Increased mucin secretion and increased cGMP production in *response* to both appeared to be mediated by a phospholipase C that hydrolyzes phosphatidylcholine ( [PC-PLC] ) , and by protein kinase C ( PKC ) , since both responses were attenuated by either D609 ( 10 and 20 microg/ml ) , a specific PC-PLC inhibitor , or by each of three PKC inhibitors : Calphostin C ( 0.3 and 0.5 microM ) , bisindoylmaleimide ( GF 109203X , Go 6850 ; 20 nM ) , or Ro31-8220 ( 10 microM ) . Regulation HSPG2 TNF 9316456 456174 Although TSH stimulation of H2O2 production is mediated by the phospholipase C (PLC)-Ca2+ pathway , and exogenous and endogenous ceramide *affected* neither TSH dependent [PLC] activation and Ca2+ mobilization nor TSH induced cAMP accumulation but attenuated Ca ( 2+ ) -induced H2O2 production . Regulation HTR2A IL1B 7552306 327492 To study the potential interaction between cytokine and serotonin ( 5-HT ) signal transduction , we evaluated the *effect* of on the [5-HT2] receptor mediated mobilization of intracellular Ca2+ in cultured rat C6BU-1 glioma cells . Regulation HTR4 TNF 1911345 167462 However , the possible *role* of in [HTR] has not been investigated . Regulation HTR6 TNF 1911345 167463 However , the possible *role* of in [HTR] has not been investigated . Regulation HTR7 TNF 1911345 167464 However , the possible *role* of in [HTR] has not been investigated . Regulation HTT CAPN8 12460554 1021866 However , they suggest that activation and [huntingtin] *regulation* merit investigation as modifiers of disease progression in neurons injured by the harmful consequences of full-length mutant huntingtin . Regulation HTT CAPN8 12832525 1105769 In contrast , activation of calpain was specifically detected in the striatum in both models and this was associated with a *dependent* cleavage of [huntingtin] . Regulation HYAL1 IL1B 18390475 1944184 We found that [Hyal-like] activity is present in the apical and basolateral secretions from HBE cells where Hyals 1 , 2 , and 3 are expressed , and that *acts* synergistically with TNF-alpha to increase gene expression and activity . Regulation HYAL2 IL1B 18390475 1944185 We found that [Hyal-like] activity is present in the apical and basolateral secretions from HBE cells where Hyals 1 , 2 , and 3 are expressed , and that *acts* synergistically with TNF-alpha to increase gene expression and activity . Regulation HYAL3 IL1B 18390475 1944186 We found that [Hyal-like] activity is present in the apical and basolateral secretions from HBE cells where Hyals 1 , 2 , and 3 are expressed , and that *acts* synergistically with TNF-alpha to increase gene expression and activity . Regulation HYAL4 IL1B 18390475 1944187 We found that [Hyal-like] activity is present in the apical and basolateral secretions from HBE cells where Hyals 1 , 2 , and 3 are expressed , and that *acts* synergistically with TNF-alpha to increase gene expression and activity . Regulation HYOU1 FOXO1 22564731 2608772 was *involved* in the regulation of [ORP150] expression because suppression of FOXO1 inhibited the induction of ORP150 by SIRT1 . Regulation IAPP FAS 19843871 2299410 Here , we investigate the *effect* of on [amylin] expression and secretion by beta-cells and explore the underlying mechanisms . Regulation IAPP FAS 19843871 2299411 the inductive *effect* of on [amylin] expression is independent of glucose concentration . Regulation IAPP FAS 19843871 2299419 These data demonstrate that differently *regulate* [amylin] and insulin expression and induce both amylin and insulin release . Regulation IAPP TNF 21116608 2383671 We investigated the *effect* of on [amylin] levels and the underlying mechanisms , using murine pancreatic beta cell line MIN6 and pancreatic islets . Regulation IARS EPHB2 19755487 2186653 In contrast IL1B decreases and inhibition of the MAPK pathway increases IRS1 promoter activity revealing opposed *effects* of IL1B and on the expression of different [IRS] proteins . Regulation IARS IL1B 19755487 2186654 In contrast IL1B decreases and inhibition of the MAPK pathway increases IRS1 promoter activity revealing opposed *effects* of and ERK on the expression of different [IRS] proteins . Regulation IBD2 ARSA 21765868 2456679 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Regulation IBD2 CTGF 15256831 1282712 The present data indicate that *plays* a different role in [IBD] and might be useful , especially in those cases with unusual disease presentation , to better differentiate UC and CD . Regulation IBD2 IL1B 19740775 2163262 IL23 and plus IL6 had no *effect* on [IBD] LPMC production of IL17 ; Regulation IBD2 ITGAL 14518246 480060 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Regulation IBD2 ITGB2 7648720 318987 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Regulation IBD2 JAG1 15294991 1279097 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Regulation IBD2 PECAM1 17510197 1772790 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Regulation IBD2 TLR7 18031248 1828254 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Regulation IBD2 TNF 11884025 893992 *plays* a role in [inflammatory bowel disease (IBD)] and is involved in the expression of inducible nitric oxide synthase (iNOS) which has also been implicated in IBD . Regulation IBD2 TNF 16093357 1481994 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Regulation IBD2 TNF 18187519 1876059 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Regulation IBD2 TNF 24548422 2915082 Several evidences suggest the *involvement* of and TACE in [inflammatory bowel disease (IBD)] . Regulation IBD2 TNF 8734357 374180 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Regulation IBD2 TNFSF10 19954896 2199276 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Regulation IBD3 ARSA 21765868 2456675 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Regulation IBD3 CTGF 15256831 1282708 The present data indicate that *plays* a different role in [IBD] and might be useful , especially in those cases with unusual disease presentation , to better differentiate UC and CD . Regulation IBD3 IL1B 19740775 2163254 IL23 and plus IL6 had no *effect* on [IBD] LPMC production of IL17 ; Regulation IBD3 ITGAL 14518246 480056 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Regulation IBD3 ITGB2 7648720 318979 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Regulation IBD3 JAG1 15294991 1279093 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Regulation IBD3 PECAM1 17510197 1772786 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Regulation IBD3 TLR7 18031248 1828214 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Regulation IBD3 TNF 11884025 893988 *plays* a role in [inflammatory bowel disease (IBD)] and is involved in the expression of inducible nitric oxide synthase (iNOS) which has also been implicated in IBD . Regulation IBD3 TNF 16093357 1481990 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Regulation IBD3 TNF 18187519 1876055 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Regulation IBD3 TNF 24548422 2915074 Several evidences suggest the *involvement* of and TACE in [inflammatory bowel disease (IBD)] . Regulation IBD3 TNF 8734357 374176 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Regulation IBD3 TNFSF10 19954896 2199272 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Regulation IBD4 ARSA 21765868 2456680 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Regulation IBD4 CTGF 15256831 1282713 The present data indicate that *plays* a different role in [IBD] and might be useful , especially in those cases with unusual disease presentation , to better differentiate UC and CD . Regulation IBD4 IL1B 19740775 2163264 IL23 and plus IL6 had no *effect* on [IBD] LPMC production of IL17 ; Regulation IBD4 ITGAL 14518246 480061 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Regulation IBD4 ITGB2 7648720 318989 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Regulation IBD4 JAG1 15294991 1279098 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Regulation IBD4 PECAM1 17510197 1772791 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Regulation IBD4 TLR7 18031248 1828264 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Regulation IBD4 TNF 11884025 893993 *plays* a role in [inflammatory bowel disease (IBD)] and is involved in the expression of inducible nitric oxide synthase (iNOS) which has also been implicated in IBD . Regulation IBD4 TNF 16093357 1481995 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Regulation IBD4 TNF 18187519 1876060 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Regulation IBD4 TNF 24548422 2915084 Several evidences suggest the *involvement* of and TACE in [inflammatory bowel disease (IBD)] . Regulation IBD4 TNF 8734357 374181 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Regulation IBD4 TNFSF10 19954896 2199277 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Regulation IBD5 ARSA 21765868 2456681 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Regulation IBD5 CTGF 15256831 1282714 The present data indicate that *plays* a different role in [IBD] and might be useful , especially in those cases with unusual disease presentation , to better differentiate UC and CD . Regulation IBD5 IL1B 19740775 2163266 IL23 and plus IL6 had no *effect* on [IBD] LPMC production of IL17 ; Regulation IBD5 ITGAL 14518246 480062 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Regulation IBD5 ITGB2 7648720 318991 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Regulation IBD5 JAG1 15294991 1279099 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Regulation IBD5 PECAM1 17510197 1772792 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Regulation IBD5 TLR7 18031248 1828274 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Regulation IBD5 TNF 11884025 893994 *plays* a role in [inflammatory bowel disease (IBD)] and is involved in the expression of inducible nitric oxide synthase (iNOS) which has also been implicated in IBD . Regulation IBD5 TNF 16093357 1481996 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Regulation IBD5 TNF 18187519 1876061 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Regulation IBD5 TNF 24548422 2915086 Several evidences suggest the *involvement* of and TACE in [inflammatory bowel disease (IBD)] . Regulation IBD5 TNF 8734357 374182 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Regulation IBD5 TNFSF10 19954896 2199278 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Regulation IBD6 ARSA 21765868 2456682 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Regulation IBD6 CTGF 15256831 1282715 The present data indicate that *plays* a different role in [IBD] and might be useful , especially in those cases with unusual disease presentation , to better differentiate UC and CD . Regulation IBD6 IL1B 19740775 2163268 IL23 and plus IL6 had no *effect* on [IBD] LPMC production of IL17 ; Regulation IBD6 ITGAL 14518246 480063 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Regulation IBD6 ITGB2 7648720 318993 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Regulation IBD6 JAG1 15294991 1279100 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Regulation IBD6 PECAM1 17510197 1772793 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Regulation IBD6 TLR7 18031248 1828284 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Regulation IBD6 TNF 11884025 893995 *plays* a role in [inflammatory bowel disease (IBD)] and is involved in the expression of inducible nitric oxide synthase (iNOS) which has also been implicated in IBD . Regulation IBD6 TNF 16093357 1481997 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Regulation IBD6 TNF 18187519 1876062 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Regulation IBD6 TNF 24548422 2915088 Several evidences suggest the *involvement* of and TACE in [inflammatory bowel disease (IBD)] . Regulation IBD6 TNF 8734357 374183 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Regulation IBD6 TNFSF10 19954896 2199279 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Regulation IBD7 ARSA 21765868 2456676 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Regulation IBD7 CTGF 15256831 1282709 The present data indicate that *plays* a different role in [IBD] and might be useful , especially in those cases with unusual disease presentation , to better differentiate UC and CD . Regulation IBD7 IL1B 19740775 2163256 IL23 and plus IL6 had no *effect* on [IBD] LPMC production of IL17 ; Regulation IBD7 ITGAL 14518246 480057 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Regulation IBD7 ITGB2 7648720 318981 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Regulation IBD7 JAG1 15294991 1279094 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Regulation IBD7 PECAM1 17510197 1772787 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Regulation IBD7 TLR7 18031248 1828224 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Regulation IBD7 TNF 11884025 893989 *plays* a role in [inflammatory bowel disease (IBD)] and is involved in the expression of inducible nitric oxide synthase (iNOS) which has also been implicated in IBD . Regulation IBD7 TNF 16093357 1481991 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Regulation IBD7 TNF 18187519 1876056 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Regulation IBD7 TNF 24548422 2915076 Several evidences suggest the *involvement* of and TACE in [inflammatory bowel disease (IBD)] . Regulation IBD7 TNF 8734357 374177 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Regulation IBD7 TNFSF10 19954896 2199273 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Regulation IBD8 ARSA 21765868 2456677 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Regulation IBD8 CTGF 15256831 1282710 The present data indicate that *plays* a different role in [IBD] and might be useful , especially in those cases with unusual disease presentation , to better differentiate UC and CD . Regulation IBD8 IL1B 19740775 2163258 IL23 and plus IL6 had no *effect* on [IBD] LPMC production of IL17 ; Regulation IBD8 ITGAL 14518246 480058 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Regulation IBD8 ITGB2 7648720 318983 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Regulation IBD8 JAG1 15294991 1279095 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Regulation IBD8 PECAM1 17510197 1772788 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Regulation IBD8 TLR7 18031248 1828234 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Regulation IBD8 TNF 11884025 893990 *plays* a role in [inflammatory bowel disease (IBD)] and is involved in the expression of inducible nitric oxide synthase (iNOS) which has also been implicated in IBD . Regulation IBD8 TNF 16093357 1481992 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Regulation IBD8 TNF 18187519 1876057 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Regulation IBD8 TNF 24548422 2915078 Several evidences suggest the *involvement* of and TACE in [inflammatory bowel disease (IBD)] . Regulation IBD8 TNF 8734357 374178 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Regulation IBD8 TNFSF10 19954896 2199274 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Regulation IBD9 ARSA 21765868 2456678 Although once widely employed in the treatment of Crohn 's disease ( CD ) , the accumulated body of evidence now suggests that there is a much more limited *role* for <5-ASA> in this particular form of [inflammatory bowel disease] . Regulation IBD9 CTGF 15256831 1282711 The present data indicate that *plays* a different role in [IBD] and might be useful , especially in those cases with unusual disease presentation , to better differentiate UC and CD . Regulation IBD9 IL1B 19740775 2163260 IL23 and plus IL6 had no *effect* on [IBD] LPMC production of IL17 ; Regulation IBD9 ITGAL 14518246 480059 The aim of this study was to evaluate the *role* of B7 and in [inflammatory bowel disease] . Regulation IBD9 ITGB2 7648720 318985 In the present study the *role* of in experimental [IBD] was studied by treatment with ED7 and OX42 , two MoAbs against CD11b/CD18 . Regulation IBD9 JAG1 15294991 1279096 The *role* of specific microbial in the induction of experimental [inflammatory bowel disease] is poorly understood . Regulation IBD9 PECAM1 17510197 1772789 The aim of this study was to determine the *role* of in experimental [IBD] and to show whether blockade of PECAM-1 has therapeutic effects . Regulation IBD9 TLR7 18031248 1828244 We pay particular attention to the *role* of signalling in idiopathic [IBD] ( inflammatory bowel disease ) and colitis associated carcinogenesis . Regulation IBD9 TNF 11884025 893991 *plays* a role in [inflammatory bowel disease (IBD)] and is involved in the expression of inducible nitric oxide synthase (iNOS) which has also been implicated in IBD . Regulation IBD9 TNF 16093357 1481993 The *role* of in [IBD] is well established , but its role in endometriosis -- also characterized by the activation of inflammatory mechanisms -- is still under study . Regulation IBD9 TNF 18187519 1876058 Given the *role* of in [inflammatory bowel disease (IBD)] and the association between increased permeability and IBD , recombinant TNF-alpha ( 10 ng/ml ) was added to the DNP ( 0.1 mM ) + E. coli ( 10 ( 6 ) colony forming units ) , and this resulted in a significantly greater loss of T84 epithelial barrier function than that elicited by DNP + E. coli . Regulation IBD9 TNF 24548422 2915080 Several evidences suggest the *involvement* of and TACE in [inflammatory bowel disease (IBD)] . Regulation IBD9 TNF 8734357 374179 These results confirm the role of inflammatory cytokines in IBD and shed a new light on the *role* of in [IBD] . Regulation IBD9 TNFSF10 19954896 2199275 To explore the *role* of in [inflammatory bowel disease (IBD)] , we examined the expression of the TRAIL/TRAIL-receptor system in colonic resections from patients with ulcerative colitis and Crohn 's disease in comparison to normal colon and appendicitis . Regulation ICAM1 ALOX5 15132836 1245622 To study the *effect* of <5-lipoxygenase> inhibitors on the expression of [intercellular adhesion molecule-1] ( ICAM-1 ) in melanoma cells . Regulation ICAM1 ANGPT1 11557733 861443 In the present study , we used human umbilical vascular endothelial cells ( HUVECs ) to examine the *effect* of on VEGF induced expression of three adhesion molecules : [intercellular adhesion molecule-1] ( ICAM-1 ) , vascular cell adhesion molecule-1 ( VCAM-1 ) , and E-selectin . Regulation ICAM1 CD14 10440639 635402 We further examined the *effects* of serum and soluble ( sCD14 ) on [ICAM-1] expression in HGF stimulated with P. gingivalis LPS . Regulation ICAM1 CD14 8945531 400313 Since HGF did not express endogenous CD14 , we investigated the *role* of human serum derived soluble ( sCD14 ) in [ICAM-1] induction on HGF by LPS . Regulation ICAM1 CD14 8945531 400315 These results show that induction of [ICAM-1] in HGF by LPS does not *involve* binding to cell surface but is mediated by serum derived sCD14 . Regulation ICAM1 GPR115 24259506 2892891 Investigating the interactions of neutrophils from wild-type , CD11a ( -/- ) , CD11b ( -/- ) , and CD18 ( null ) mice with wild-type , junctional adhesion molecule-A ( -/- ) , ICAM-1 ( null ) , ICAM-2 ( -/- ) , or ICAM-1 ( null ) /ICAM-2 ( -/- ) primary mouse brain microvascular endothelial cells , we demonstrate that neutrophil arrest , polarization , and crawling required *dependent* activation of ß2 integrins and binding to endothelial [ICAM-1] . Regulation ICAM1 GPR132 24259506 2892880 Investigating the interactions of neutrophils from wild-type , CD11a ( -/- ) , CD11b ( -/- ) , and CD18 ( null ) mice with wild-type , junctional adhesion molecule-A ( -/- ) , ICAM-1 ( null ) , ICAM-2 ( -/- ) , or ICAM-1 ( null ) /ICAM-2 ( -/- ) primary mouse brain microvascular endothelial cells , we demonstrate that neutrophil arrest , polarization , and crawling required *dependent* activation of ß2 integrins and binding to endothelial [ICAM-1] . Regulation ICAM1 GPR87 24259506 2892960 Investigating the interactions of neutrophils from wild-type , CD11a ( -/- ) , CD11b ( -/- ) , and CD18 ( null ) mice with wild-type , junctional adhesion molecule-A ( -/- ) , ICAM-1 ( null ) , ICAM-2 ( -/- ) , or ICAM-1 ( null ) /ICAM-2 ( -/- ) primary mouse brain microvascular endothelial cells , we demonstrate that neutrophil arrest , polarization , and crawling required *dependent* activation of ß2 integrins and binding to endothelial [ICAM-1] . Regulation ICAM1 HES2 16247329 1471585 The *effect* of on endothelial cell surface expression of E-selectin , P-selectin , vascular cell adhesion molecule-1 ( VCAM-1 ) , and intracellular adhesion molecule-1 ( [ICAM-1] ) was evaluated by enzyme linked immunoabsorbant assay . Regulation ICAM1 HES2 16247329 1471641 After stimulation with IL-1 ( 10 U/mL ) , had no *effect* on the expression of P-selectin , E-selectin , [ICAM-1] , or VCAM-1 . Regulation ICAM1 IL1B 10532635 562350 To investigate the *role* of in regulation of tumor necrosis factor-alpha (TNF-alpha) and [intercellular adhesion molecule-1] ( ICAM-1 ) during focal cerebral ischemia , the authors studied mutant mice deficient in the IL-1 converting enzyme (ICE) gene ( ICE knockout [ KO ] mice ) . Regulation ICAM1 IL1B 15275879 1276744 The purpose of this study was to investigate the involvement of stress activated mitogen activated protein kinases in the *regulation* of [ICAM-1] expression by tumor necrosis factor-alpha (TNF-alpha) and in serosal fibroblasts isolated from patients with Crohn 's disease . Regulation ICAM1 IL1B 1681812 169076 Combinations of IFN gamma + TNF alpha and IFN gamma + had a synergistic *effect* on [intercellular adhesion molecule 1] ( ICAM-1 ) expression and adhesion . Regulation ICAM1 IL1B 16953820 1611001 Although numerous *effects* of on mesenchymal cells are known , e.g. up-regulation of [intercellular adhesion molecule-1] in endothelial cells , little is known of the effects of interleukin-1beta on oral keratinocytes . Regulation ICAM1 IL1B 17693924 1882325 Lastly , inhibition of exportin 1 attenuates monocyte chemoattractant protein , IL-8 , and [intercellular adhesion molecule] expression in *response* to stimulation . Regulation ICAM1 IL1B 19278584 2046329 To investigate the *effects* of on [intercellular adhesion molecule-1] ( ICAM-1 ) expression on A549 cell and underlying signal transduction pathways . Regulation ICAM1 IL1B 7867034 287296 actively *regulates* functional [ICAM-1] expression in vascular smooth muscle cells . Regulation ICAM1 IL1B 7910170 254300 *Regulation* of [intercellular adhesion molecule-1] gene expression by tumor necrosis factor-alpha , , and interferon-gamma in astrocytes . Regulation ICAM1 IL1B 7945915 276582 Both the normal and systemic sclerosis dermal fibroblasts increased their cell surface expression of [ICAM-1] in *response* to , tumor necrosis factor-alpha (TNF-alpha) , and interferon-gamma (IFN-gamma) in a dose dependent fashion . Regulation ICAM1 IL1B 8095960 214515 Cytokine induced ICAM-1 expression was specific , because IL-1 alpha , , IL-2 , IL-4 , IL-6 , IL-7 , IL-8 , C5a , and platelet activating factor did not significantly *affect* eosinophil [ICAM-1] surface expression . Regulation ICAM1 IL1B 8103647 228941 We used this approach to analyze the different *effects* of TNF-alpha , , and purified porcine platelet derived growth factor stimulations on [ICAM-1] expression in smooth muscle cells . Regulation ICAM1 IL1B 8607877 352666 However , the upregulation of [ICAM-1] mRNA levels in *response* to was much more stable than the transient induction of E-selectin and VCAM-1 transcripts . Regulation ICAM1 IL1B 9002065 404746 To evaluate the *participation* of in posttraumatic [ICAM-1] expression on glia in vivo , we performed the following experiments . Regulation ICAM1 IL1B 9002065 404747 We conclude , therefore , that *affects* [ICAM-1] expression on glia in vivo after experimental brain injury and presumably plays an important role in brain wound repair . Regulation ICAM1 IL1B 9197378 438555 In addition , pretreatment of infected monocytes with a TNF-alpha synthesis inhibitor , RP 55778 , or with MAbs directed against IL-1beta , confirmed the *role* of TNF-alpha and in the regulation of CD18 , CD44 , and [CD54] expression . Regulation ICAM1 IL1B 9378369 465562 In conclusion , our data suggest that TNF-alpha and are not *responsible* for the upregulation of [ICAM-1] in hyperoxia exposed mouse lungs . Regulation ICAM1 IL1B 9820785 547942 Neither IL-4 , IL-1alpha nor *affected* [ICAM-1] expression in a consistent fashion . Regulation ICAM1 ITGAL 10639327 660469 Taken together , these data demonstrate that low affinity LFA-1 binding to ICAM-3 *regulates* strong [LFA-1/ICAM-1] mediated adhesion by driving into clusters to facilitate cell-cell interactions that take place in the immune system . Regulation ICAM1 ITGAL 11165259 782756 We show that CD98 cross linking persistently activates Rap1 GTPase in a *dependent* manner and induces [LFA-1/ICAM-1] mediated cell adhesion in lymphocytes . Regulation ICAM1 ITGAL 11904622 923074 Nicotine exerts inhibitory *effects* on both endothelial cell surface [intercellular adhesion molecule] expression and neutrophil integrin expressions of CD62L , , and CD11b in vitro . Regulation ICAM1 ITGAL 1348028 182736 These studies provide evidence that [ICAM-1] and ICAM-2 are not important *target* cell ligands for NK effector cell and that other target cell ICAM may exist . Regulation ICAM1 ITGB2 10639327 660470 Taken together , these data demonstrate that low affinity binding to ICAM-3 *regulates* strong [LFA-1/ICAM-1] mediated adhesion by driving LFA-1 into clusters to facilitate cell-cell interactions that take place in the immune system . Regulation ICAM1 ITGB2 1356124 195880 In this assay , the protein kinase C-activating phorbol ester PDB and anti-IgM antibodies , as well as the protein kinase inhibitor , staurosporine , were able to induce *dependent* binding to [ICAM-1] . Regulation ICAM1 ITGB2 8103026 225993 These studies indicate that aspirin promotes neutrophil adherence to endothelium via CD11a/CD18- and *dependent* interactions with [intercellular adhesion molecule 1] ; Regulation ICAM1 ITGB2 8774994 344299 Recent studies have indicated that aspirin promotes neutrophil adherence to endothelium via *dependent* interactions with [intercellular adhesion molecule 1] , which subsequently leads to neutrophil mediated cell injury . Regulation ICAM1 ITGB2 8995280 409440 With respect to other ligands , mAbs 1G12 and 2D5 completely inhibited attachment of Plasmodium falciparum infected erythrocytes to immobilized recombinant ICAM-1-Fc , whereas they had no effect on *dependent* T cell binding to [ICAM-1-Fc] . Regulation ICAM1 LBP 16123407 1449369 Neither sCD14 nor alone *affected* the expression of chemokines or [ICAM-1] in cultured human corneal fibroblasts . Regulation ICAM1 LIPG 18093422 1838158 To explore the relationship between human umbilical vascular endothelial cells ( HUVECs ) and , and the *effect* of EL on expression of endothelial cell adhesion molecule ( [ICAM] ) . Regulation ICAM1 MAP2K6 11483407 844313 However , TNF-alpha induced [ICAM-1] expression was not *affected* by either inhibitor , PD 98059 , or p38 inhibitor , SB 203580 . Regulation ICAM1 MAP2K6 22845610 2677013 Endothelial Japanese encephalitis virus infection enhances migration and adhesion of leukocytes to brain microvascular endothelia via *dependent* expression of [ICAM1] and the CINC and RANTES chemokines . Regulation ICAM1 MMP28 12789230 1097255 An aim of this study was to evaluate the *effect* of inhibitors on the expression of [ICAM-1] and VCAM-1 in the migration of inflammatory cells in a murine model of TDI induced asthma . Regulation ICAM1 MMP28 12789230 1097301 We used a murine model to investigate TDI induced asthma to examine the possible involvement of ICAM-1 and VCAM-1 in the pathogenesis of that disease and the *effect* of inhibitors on the expression of [ICAM-1] and VCAM-1 . Regulation ICAM1 MMP7 12789230 1097270 An aim of this study was to evaluate the *effect* of inhibitors on the expression of [ICAM-1] and VCAM-1 in the migration of inflammatory cells in a murine model of TDI induced asthma . Regulation ICAM1 MMP7 12789230 1097316 We used a murine model to investigate TDI induced asthma to examine the possible involvement of ICAM-1 and VCAM-1 in the pathogenesis of that disease and the *effect* of inhibitors on the expression of [ICAM-1] and VCAM-1 . Regulation ICAM1 PECAM1 17662049 1799123 We present evidence that the PECAM-1 associated tyrosine phosphatase SHP-2 is required for ICAM-1 signaling , suggesting that its activity might crucially contribute to the *regulation* of [ICAM-1] signaling by . Regulation ICAM1 SELL 11904622 923073 Nicotine exerts inhibitory *effects* on both endothelial cell surface [intercellular adhesion molecule] expression and neutrophil integrin expressions of , CD11a , and CD11b in vitro . Regulation ICAM1 SRGN 19123332 2004909 To investigate the *effects* of on serum inflammatory factors and protein expression of cyclooxygenase-2 (COX-2) and [intercellular adhesion molecule-1] ( ICAM-1 ) in ischemic myocardium of rats with acute myocardial infarction ( AMI ) . Regulation ICAM1 SRGN 19271170 2045708 To investigate the *effects* of on cellular adhesion between human To investigate the effects of Propyl Gallate (PrG) on cellular adhesion between human umbilical vein endothelial cells ( HUVEC ) and polymorphonuclear leukocytes ( PMN ) as well as the expression umbilical vein endothelial cells ( HUVEC ) and polymorphonuclear leukocytes ( PMN ) as well as the expression of [intercellular adhesion molecule-1] ( ICAM-1 , CD54 ) and E-selectin ( CD62E ) on the VEC surface . Regulation ICAM1 TNF 10082656 599110 RA potentiated the induced [ICAM-1] *response* in all Ca2+-concentrations . Regulation ICAM1 TNF 10206577 606511 We evaluated the *effect* of 24-hour or interleukin 4 (IL-4) incubation on the expression of mast cell c-kit , [ICAM-1] , and surface bound IgE . Regulation ICAM1 TNF 10407627 629768 *Roles* of and transforming growth factor-beta in regulating [intercellular adhesion molecule-1] expression on murine peritoneal macrophages infected with M. leprae . Regulation ICAM1 TNF 10411124 630626 The *effect* of TSH/forskolin , as well as and IFN-gamma , on [ICAM-1] RNA levels is transcriptional . Regulation ICAM1 TNF 10491002 645882 These data indicate that is largely *responsible* for the early up-regulation of endothelial [ICAM-1] and VCAM-1 , but that IL-1 enhances expression in late disease . Regulation ICAM1 TNF 10495789 478590 Hydroxy-methoxy acetophenone , an inhibitor of NADPH dependent oxidase , also attenuated RANTES and [ICAM-1] in *response* to or IgG . Regulation ICAM1 TNF 10678917 668322 Candidal induction of [ICAM-1] expression was *independent* of , IL-1alpha , and IL-1beta . Regulation ICAM1 TNF 10976991 729648 In the present study , we investigated effects of a synthetic glucocorticoid , dexamethasone ( Dex ) , on *dependent* activation of NF-kappaB and expression of the [ICAM-1] gene . Regulation ICAM1 TNF 11198351 779652 Exposure of BSO treated cells to the reducing agent dithiothreitol ( DTT ) before TNFalpha treatment or supplementation of nuclear extract ( isolated after TNFalpha challenge of BSO treated cells ) with DTT significantly augmented the *effect* of on NF-kappaB binding activity and [ICAM-1] mRNA expression . Regulation ICAM1 TNF 11225735 580992 NF-kappaB activation was greatly potentiated by increased 15-LO activity in the stably transduced cells , and both VCAM-1 and [ICAM-1] were significantly induced in these cells in *response* to and phorbol 12-myristate 13-acetate ( PMA ) stimulation , as studied by flow cytometry . Regulation ICAM1 TNF 11450703 836647 Furthermore , the inhibitors completely prevented the *dependent* induction of MMP-1 , MMP-3 , [ICAM-1] , and COX-2 mRNAs . Regulation ICAM1 TNF 11817671 892847 The present study shows that [ICAM-1] expression is significantly elevated on alveolar macrophages from patients with sarcoidosis in *response* to and interferon-gamma (INF-gamma) compared with healthy controls . Regulation ICAM1 TNF 11970912 933281 To test this hypothesis , *effects* of IFN-gamma or on expression of [intercellular adhesion molecule (ICAM)-1] , rhinovirus binding , and virus induced chemokine secretion on A549 and human bronchial epithelial cells ( HBEC ) were determined . Regulation ICAM1 TNF 12111363 963494 *regulates* the expression of [ICAM-1] predominantly through TNF receptor 1 after chronic constriction injury of mouse sciatic nerve . Regulation ICAM1 TNF 12111363 963496 Our data support the hypothesis that *regulates* the expression of [ICAM-1] predominantly through TNFR1 . Regulation ICAM1 TNF 12384485 998803 Endothelial cell [ICAM-1] upregulation in *response* to is mediated in part by reactive oxygen species ( ROS ) generated by the endothelial membrane associated NADPH oxidase and occurs maximally after 4 h as the synthesis of new protein is required . Regulation ICAM1 TNF 12580918 1058388 We investigated the *effect* of on [ICAM-1] expression of eosinophils . Regulation ICAM1 TNF 12738545 1087964 The *effect* of the proinflammatory cytokine on the expression of [intercellular adhesion molecule (ICAM)-1] by cultured human keratocytes was investigated because the interaction of leukocytes with ICAM-1 expressed on the surface of structural cells mediates leukocyte infiltration into tissue at sites of inflammation . Regulation ICAM1 TNF 1346267 179100 The *effects* of recombinant human interleukin 1 alpha (IL-1 alpha) , interleukin 1 beta (IL-1 beta) , interleukin 6 (IL-6) , granulocyte/macrophage colony stimulating factor ( GM-CSF ) and on the cell proliferation and the expression of [intercellular adhesion molecule-1] ( ICAM-1 ) were assessed in cultured human dermal microvascular endothelial cells ( HDMEC ) . Regulation ICAM1 TNF 1351055 188081 These results suggest that PMA acts through protein kinase C to up-regulate ICAM-1 expression primarily at a post-transcriptional level by stabilizing ICAM-1 mRNA , whereas transcriptionally *regulates* [ICAM-1] gene expression through an undefined , protein kinase C-independent pathway . Regulation ICAM1 TNF 1374588 186321 In contrast , dermal fibroblasts upregulated [intercellular adhesion molecule-1] ( ICAM-1 ) but not VCAM-1 expression in *response* to . Regulation ICAM1 TNF 1381227 196041 The present study aimed to see whether TNF induction of ELAM-1 and [ICAM-1] on human umbilical vein endothelial cells ( HUVECs ) *involved* novel interactions . Regulation ICAM1 TNF 1382639 198301 Exposure of HUVEC to perflubron did not alter the up-regulation of [ICAM] or ELAM in *response* to IL-1 or ( n = 20 ) . Regulation ICAM1 TNF 14565715 1154957 HPVEC express E-selectin , [ICAM-1] , and VCAM-1 in *response* to the inflammatory cytokine similarly to other types of cultured human endothelial cells . Regulation ICAM1 TNF 14583404 1158920 In *response* to , isolated mouse brain endothelial cells ( MBEC ) express vascular cell adhesion molecule-1 ( VCAM-1 ) and [intercellular adhesion molecule-1] ( ICAM-1 ) . Regulation ICAM1 TNF 15275879 1276743 The purpose of this study was to investigate the involvement of stress activated mitogen activated protein kinases in the *regulation* of [ICAM-1] expression by and interleukin-1beta (IL-1beta) in serosal fibroblasts isolated from patients with Crohn 's disease . Regulation ICAM1 TNF 15578421 1355836 The present study suggests that IL-1 alpha and may , at least in part , be *responsible* for the increased [ICAM-1] expression on endothelium in cutaneous microvessels , resulting in the vascular injury characterized by neutrophilic leukocytoclasis in B/WF1 mice . Regulation ICAM1 TNF 16259720 1477817 Ea.hy.926 human immortal HUVECs expressed [ICAM-1] in *response* to and PMA . Regulation ICAM1 TNF 1680933 166566 Moreover , the well known synergistic *effect* of IFN gamma plus on keratinocyte [ICAM-1] induction could be mimicked by stimulation of cells with IFN gamma plus anti-55-kd TNFR antibodies . Regulation ICAM1 TNF 16892784 1597136 is *involved* in the up-regulation of [intercellular adhesion molecule 1] ( ICAM-1 ) . Regulation ICAM1 TNF 17161959 1694547 Taken together , these findings illustrate the central role *played* by in the regulation of [ICAM-1] . Regulation ICAM1 TNF 17238806 1664239 We used flow cytometry and either primary cultured human conjunctival cells or the Chang conjunctival cell model to determine the effects of glucosamine sulfate on the production of [ICAM-1] in *response* to , interferon (IFN)-gamma , interleukin (IL)-1beta , IL-6 , TNF-alpha plus IFN-gamma , or TNF-alpha plus IL-1beta . Regulation ICAM1 TNF 17683945 1781399 The interaction between myocardial depressant factors in endotoxemic cardiac dysfunction : *role* of in TLR4 mediated [ICAM-1] expression . Regulation ICAM1 TNF 17683945 1781402 is *involved* in the regulation of myocardial [ICAM-1] expression by TLR4 . Regulation ICAM1 TNF 17988550 1821566 The inflammatory mediator [intercellular adhesion molecule-1] ( ICAM-1 ) expression in *response* to lipopolysaccharide and was compared between adenovirus E1A positive clones , control clones and CCL149 cells . Regulation ICAM1 TNF 18487372 1951677 Upregulation of TNFR1 expression by priming with TAPI-2 and IFNgamma resulted in enhanced [ICAM-1] expression in *response* to stimulation ( significant change in the slope of the dose-response curve ) . Regulation ICAM1 TNF 18988888 2015877 This study aimed to investigate the regulated expression of the newly identified adiponectin receptors ( AdipoR1 and 2 ) and their roles in the endothelial expression of [intercellular adhesion molecule-1] ( ICAM-1 ) in *response* to . Regulation ICAM1 TNF 19136606 2042721 In the cells cultured under a low-glucose condition when no increased HBP flux occurred , azaserine enhanced the manganese-superoxide dismutase ( MnSOD ) protein level and also inhibited the oxidative stress and the expression of VCAM-1 and [ICAM-1] in *response* to . Regulation ICAM1 TNF 19153536 2038073 Monocyte derived *plays* an important role in the up-regulation of [ICAM-I] on eosinophils induced by lipopolysaccharides . Regulation ICAM1 TNF 19320886 2052444 We aimed to investigate the *effect* of on the expression of [intercellular adhesion molecule-1] ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) in the migration ability of mesenchymal stem cells ( MSCs ) in the context of wound healing . Regulation ICAM1 TNF 1979587 145148 We investigated the *effects* of recombinant human on cell proliferation and on expression of MHC class II antigens and intercellular adhesion molecule [ICAM-1] in human dermal microvascular endothelial cells ( HDMEC ) derived from human foreskin . Regulation ICAM1 TNF 19875721 2187915 CD31 ( + ) cells purified from differentiating EBs upregulated [ICAM-1] and VCAM-1 in *response* to , confirming their ability to function as endothelial cells . Regulation ICAM1 TNF 20592773 2181649 We recently demonstrated that hyperglycemia increases oxidative stress and HBP flux in endothelial cells and enhances endothelial expression of vascular adhesion molecule-1 (VCAM-1) and [intercellular adhesion molecule-1] ( ICAM-1 ) in *response* to through oxidative stress rather than HBP pathway . Regulation ICAM1 TNF 20966395 2365262 Erg inhibited *dependent* activation of the [ICAM-1] promoter , nuclear factor ( NF ) -?B activity , and NF-?B p65 phosphorylation . Regulation ICAM1 TNF 2115318 137412 The *effects* of recombinant human on cell proliferation , cell morphology , and on the expression of class II alloantigens and intercellular adhesion molecule-1 ( [ICAM-1] ) were assessed in human keratinocytes cultured in serum-free medium . Regulation ICAM1 TNF 21507295 2418530 To study the *effects* of on [ICAM-1] and LFA-1 expression in peripheral blood mononuclear cells ( PBMC ) of children with febrile seizures ( FS ) . Regulation ICAM1 TNF 21981016 2547166 We investigated how expression of [ICAM-1] , VCAM-1 , MAdCAM-1 , PECAM-1 , E- and P-selectin in *response* to , IL-1ß and IFN-? was altered by aglycemia ( A ) , hypoxia ( H ) or combined oxygen glucose deprivation ( OGD ) . Regulation ICAM1 TNF 22708120 2616097 Quantitative reverse transcriptase PCR and Western blot analyses indicated that IL-33 mediates the expression of [intercellular adhesion molecule (ICAM)-1] and vascular cell adhesion molecule (VCAM)-1 in endothelial cells basally and in *response* to . Regulation ICAM1 TNF 23264465 2741396 Importantly , ERM knockdown also reduced [ICAM-1] expression in *response* to the proinflammatory cytokine . Regulation ICAM1 TNF 24479486 2918451 Importantly , we observed pronounced *effects* of ß2-adrenergic receptor agonists and on IL-6 , CXCL2 , CXCL3 , VCAM1 , and [ICAM1] expression , suggesting a role in inflammatory brain cell homeostasis . Regulation ICAM1 TNF 3137261 95934 The expression of [intercellular adhesion molecule-1] ( ICAM-1 ) on primary human fibroblasts , a human fibrosarcoma , chondrosarcoma , and adenocarcinoma cell line in *response* to IL-1 , , or IFN-gamma was studied using an ELISA with anti-ICAM-1 mAb . Regulation ICAM1 TNF 7507414 244560 The addition of interferon-gamma delays the time at which peak expression of [ICAM-1] in *response* to stimulation occurs . Regulation ICAM1 TNF 7578984 333397 The current study was undertaken to investigate the role of TNF-R75 in *regulation* of E-selectin and [ICAM-1] expression by on HUVEC . Regulation ICAM1 TNF 7693807 234229 Furthermore , although , preincubation of bEND.3 cells with IFN-gamma modestly increases the induction of [ICAM-1] and VCAM-1 in *response* to and IL-1 , it dramatically reduces the TNF-alpha , IL-1 , and LPS induced expression of MAdCAM-1 . Regulation ICAM1 TNF 7706764 297857 The level of [ICAM-1] expression in *response* to and ultraviolet radiation ( UVR ) in individual strains was highly correlated in three different comparisons : level of stimulated response versus baseline ( TNF-alpha and UVR both p < 0.0001 ) ; Regulation ICAM1 TNF 7822333 293058 Previously , we had shown that the [ICAM-1] gene expression in human umbilical vein endothelial cells ( HUVECs ) was transcriptionally *regulated* by ( Wertheimer , S. J. , Myers , C. L. , Wallace , R. W. , and Parks , T. P. ( 1992 ) J. Biol. Chem. 267 , 12030-12035 ) . Regulation ICAM1 TNF 7902093 234545 To examine the regulation of the [intercellular adhesion molecule 1] ( ICAM-1 ) gene in cultured human synovial fibroblasts in *response* to , and investigate its modulation by the synthetic glucocorticoid , dexamethasone . Regulation ICAM1 TNF 7907090 250381 Transcription *regulation* of the human [intercellular adhesion molecule-1] gene by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate ( TPA ) , , and the glucocorticoid dexamethasone was studied using transient transfections in 293 cells with intercellular adhesion molecule-1 promoter-luciferase constructs ( together with a glucocorticoid receptor expression vector ) . Regulation ICAM1 TNF 7910170 254298 *Regulation* of [intercellular adhesion molecule-1] gene expression by , interleukin-1 beta , and interferon-gamma in astrocytes . Regulation ICAM1 TNF 7945915 276580 Both the normal and systemic sclerosis dermal fibroblasts increased their cell surface expression of [ICAM-1] in *response* to interleukin-1 beta (IL-1 beta) , , and interferon-gamma (IFN-gamma) in a dose dependent fashion . Regulation ICAM1 TNF 8100455 222544 Exposure of HUVEC to perflubron did not alter the upregulation of [ICAM] or ELAM in *response* to IL-1 or ( n = 20 ) . Regulation ICAM1 TNF 8103647 228940 We used this approach to analyze the different *effects* of , IL-1 beta , and purified porcine platelet derived growth factor stimulations on [ICAM-1] expression in smooth muscle cells . Regulation ICAM1 TNF 8356403 227510 To establish whether EA-hy-926 could be used as a model for endothelial cells ( EC ) in leucocyte-EC adhesion interactions , the *effect* of interleukin-4 (IL-4) , or interferon-gamma (IFN) stimulation on their adhesiveness and expression of E-selectin , vascular cell adhesion molecule-1 ( VCAM-1 ) and [intercellular adhesion molecule-1] ( ICAM-1 ) was compared with that of HUVEC and A549 . Regulation ICAM1 TNF 8364888 229222 The combined *effect* of IL-6 and consistently caused an increased expression of [ICAM-1] , which was greater than the sum of each one alone and also sustained for 72 h following cytokine withdrawal . Regulation ICAM1 TNF 8822088 384796 However , in the in vitro study , FK506 failed to inhibit the up-regulated [ICAM-1] expression on endothelial cells in *response* to . Regulation ICAM1 TNF 8879188 390696 In this report , we examined the *effects* of and interferon-gamma (IFN gamma) on specific lung cell expression of [ICAM-1] in vivo and the accompanying morphological changes . Regulation ICAM1 TNF 8906209 394122 *Effects* of on [ICAM-1] surface expression was investigated in both primary cultures of normal human bronchial epithelial ( NHBE ) cells and immortalized human bronchial epithelial cell line BEAS-2B . Regulation ICAM1 TNF 8930885 397461 In the present study , we characterized the *effects* of on [ICAM-1] expression in different tissues of the rat . Regulation ICAM1 TNF 8973625 403049 The *involvement* of in this [ICAM-1] expression was shown by the in vitro effect of alveolar macrophage supernatants on adhesion molecule expression by endothelial cells and epithelial cells ( this effect was neutralized by anti-TNF antibodies ) and by the increased production of TNF in the lung of pneumoconiotic patients . Regulation ICAM1 TNF 9056676 417472 *Regulation* of [intercellular adhesion molecule-1] gene by is mediated by the nuclear factor-kappaB heterodimers p65/p65 and p65/c-Rel in the absence of p50 . Regulation ICAM1 TNF 9155652 431621 The specific *role* of in mediating [ICAM-1] expression in cultured monocytes could be confirmed by the finding that a neutralizing anti-TNF-alpha antibody partially down-regulated ICAM-1 expression . Regulation ICAM1 TNF 9184788 436674 The *effects* of combined exposure to subthreshold hyperoxia and the inflammatory cytokine on the expression of [intercellular adhesion molecule-1] ( ICAM-1 ) were examined in bovine lung microvascular endothelial cells ( BLuEC ) . Regulation ICAM1 TNF 9197378 438554 In addition , pretreatment of infected monocytes with a TNF-alpha synthesis inhibitor , RP 55778 , or with MAbs directed against IL-1beta , confirmed the *role* of and IL-1beta in the regulation of CD18 , CD44 , and [CD54] expression . Regulation ICAM1 TNF 9238436 445822 No significant difference occurred between the *effects* of IL-1 and on the [ICAM-1] expression . Regulation ICAM1 TNF 9378369 465561 In conclusion , our data suggest that and IL-1 beta are not *responsible* for the upregulation of [ICAM-1] in hyperoxia exposed mouse lungs . Regulation ICAM1 TNF 9407069 470794 Differential *regulation* of interleukin-8 and [intercellular adhesion molecule-1] by H2O2 and in endothelial and epithelial cells . Regulation ICAM1 TNF 9414135 471834 *Effects* of and pentoxifylline on [ICAM-1] expression on human polymorphonuclear granulocytes . Regulation ICAM1 TNF 9442377 475206 A kappa B-site was identified in the promoter of the intercellular adhesion molecule-1 ( ICAM-1 ) gene , which is involved in *regulation* of [ICAM-1] expression by and glucocorticoids . Regulation ICAM1 TNF 9570915 501660 After two immunomagnetic purification steps , a homogenous population of HDMEC was obtained which showed typical cobblestone morphology , expressed CD31 and von Willebrand factor , proliferated in response to vascular endothelial growth factor , upregulated the expression of [intercellular adhesion molecule-1] and vascular adhesion molecule-1 in *response* to , and formed capillary-like tubes in a three-dimensional collagen type I matrix . Regulation ICAM1 TNF 9626989 511988 The *effect* of or IL-1-alpha on the gene expression of [ICAM-1] and cytokines was examined by using RGM-1 cells as a model for gastric mucosal cells . Regulation ICAM1 TNF 9718198 528197 An antioxidant , N-acetyl-L-cysteine , significantly attenuated the TNF-alpha dependent increase in these mRNAs , and simultaneously reduced the activation of NF-kappaB by TNF-alpha , indicating that NF-kappaB mediates the *dependent* expression of IL-6 and [ICAM-1] in ROS17/2.8 cells . Regulation ICAM1 TNF 9732234 530575 The *effect* of interferon-gamma and on the expression of [ICAM-1] and HLA-DR molecules on cells of a human germ cell neoplasm and their susceptibility to lysis by lymphokine activated killer cells . Regulation ICAM1 TNF 9732234 530577 In the present study , we analyzed the *effect* of IFN-gamma and on both the expression of HLA-DR and [ICAM-1] molecules on HGCN ( Germa-2 ) , and on their susceptibility to lysis by LAK cells . Regulation ICAM1 TNF 9830008 551259 We previously demonstrated that and H2O2 differentially *regulate* interleukin-8 (IL-8) and [intercellular adhesion molecule] ( ICAM-1 ) gene expression in endothelial and epithelial cells . Regulation ICAM1 TNF 9886270 584614 Furthermore , the SPC induced ICAM-1 expression was partially abolished by the concomitant addition of anti-TNF-alpha , suggesting a partial autocrine *involvement* of in [ICAM-1] expression . Regulation ICAM1 TNF 9919421 559220 For investigations of the *effect* of ( 2.5 , 5 , 10 , and 20 ng/ml ) on the surface expression of [ICAM-1] , monoclonal anti-ICAM-1 antibodies ( 84H10 ) were used . Regulation ICAM1 TNF 9919421 559223 These results suggest that the cytokine *regulates* the expression of [ICAM-1] in both human coronary endothelial cells and SMC , and could therefore play an important role in the pathophysiology of inflammatory and immune processes in restenosis after angioplasty . Regulation ICAM2 IL1B 10223354 561286 We have studied the *effect* of TNF-alpha and on [ICAM-2] expression on human umbilical vein endothelial cells ( HUVECs ) . Regulation ICAM2 IL1B 17693924 1882326 Lastly , inhibition of exportin 1 attenuates monocyte chemoattractant protein , IL-8 , and [intercellular adhesion molecule] expression in *response* to stimulation . Regulation ICAM2 ITGAL 11904622 923077 Nicotine exerts inhibitory *effects* on both endothelial cell surface [intercellular adhesion molecule] expression and neutrophil integrin expressions of CD62L , , and CD11b in vitro . Regulation ICAM2 ITGAL 1348028 182737 These studies provide evidence that ICAM-1 and [ICAM-2] are not important *target* cell ligands for NK effector cell and that other target cell ICAM may exist . Regulation ICAM2 LIPG 18093422 1838159 To explore the relationship between human umbilical vascular endothelial cells ( HUVECs ) and , and the *effect* of EL on expression of endothelial cell adhesion molecule ( [ICAM] ) . Regulation ICAM2 SELL 11904622 923076 Nicotine exerts inhibitory *effects* on both endothelial cell surface [intercellular adhesion molecule] expression and neutrophil integrin expressions of , CD11a , and CD11b in vitro . Regulation ICAM2 TNF 10223354 561285 We have studied the *effect* of and IL-1beta on [ICAM-2] expression on human umbilical vein endothelial cells ( HUVECs ) . Regulation ICAM2 TNF 1382639 198303 Exposure of HUVEC to perflubron did not alter the up-regulation of [ICAM] or ELAM in *response* to IL-1 or ( n = 20 ) . Regulation ICAM2 TNF 8100455 222546 Exposure of HUVEC to perflubron did not alter the upregulation of [ICAM] or ELAM in *response* to IL-1 or ( n = 20 ) . Regulation ICAM2 TNF 9830008 551260 We previously demonstrated that and H2O2 differentially *regulate* interleukin-8 (IL-8) and [intercellular adhesion molecule] ( ICAM-1 ) gene expression in endothelial and epithelial cells . Regulation ICAM3 IL1B 17693924 1882327 Lastly , inhibition of exportin 1 attenuates monocyte chemoattractant protein , IL-8 , and [intercellular adhesion molecule] expression in *response* to stimulation . Regulation ICAM3 ITGAL 11904622 923080 Nicotine exerts inhibitory *effects* on both endothelial cell surface [intercellular adhesion molecule] expression and neutrophil integrin expressions of CD62L , , and CD11b in vitro . Regulation ICAM3 LIPG 18093422 1838160 To explore the relationship between human umbilical vascular endothelial cells ( HUVECs ) and , and the *effect* of EL on expression of endothelial cell adhesion molecule ( [ICAM] ) . Regulation ICAM3 SELL 11904622 923079 Nicotine exerts inhibitory *effects* on both endothelial cell surface [intercellular adhesion molecule] expression and neutrophil integrin expressions of , CD11a , and CD11b in vitro . Regulation ICAM3 TNF 1382639 198305 Exposure of HUVEC to perflubron did not alter the up-regulation of [ICAM] or ELAM in *response* to IL-1 or ( n = 20 ) . Regulation ICAM3 TNF 8100455 222548 Exposure of HUVEC to perflubron did not alter the upregulation of [ICAM] or ELAM in *response* to IL-1 or ( n = 20 ) . Regulation ICAM3 TNF 9830008 551261 We previously demonstrated that and H2O2 differentially *regulate* interleukin-8 (IL-8) and [intercellular adhesion molecule] ( ICAM-1 ) gene expression in endothelial and epithelial cells . Regulation ICAM4 IL1B 17693924 1882328 Lastly , inhibition of exportin 1 attenuates monocyte chemoattractant protein , IL-8 , and [intercellular adhesion molecule] expression in *response* to stimulation . Regulation ICAM4 ITGAL 11904622 923083 Nicotine exerts inhibitory *effects* on both endothelial cell surface [intercellular adhesion molecule] expression and neutrophil integrin expressions of CD62L , , and CD11b in vitro . Regulation ICAM4 LIPG 18093422 1838161 To explore the relationship between human umbilical vascular endothelial cells ( HUVECs ) and , and the *effect* of EL on expression of endothelial cell adhesion molecule ( [ICAM] ) . Regulation ICAM4 SELL 11904622 923082 Nicotine exerts inhibitory *effects* on both endothelial cell surface [intercellular adhesion molecule] expression and neutrophil integrin expressions of , CD11a , and CD11b in vitro . Regulation ICAM4 TNF 1382639 198307 Exposure of HUVEC to perflubron did not alter the up-regulation of [ICAM] or ELAM in *response* to IL-1 or ( n = 20 ) . Regulation ICAM4 TNF 8100455 222550 Exposure of HUVEC to perflubron did not alter the upregulation of [ICAM] or ELAM in *response* to IL-1 or ( n = 20 ) . Regulation ICAM4 TNF 9830008 551262 We previously demonstrated that and H2O2 differentially *regulate* interleukin-8 (IL-8) and [intercellular adhesion molecule] ( ICAM-1 ) gene expression in endothelial and epithelial cells . Regulation ICAM5 IL1B 17693924 1882329 Lastly , inhibition of exportin 1 attenuates monocyte chemoattractant protein , IL-8 , and [intercellular adhesion molecule] expression in *response* to stimulation . Regulation ICAM5 ITGAL 11904622 923086 Nicotine exerts inhibitory *effects* on both endothelial cell surface [intercellular adhesion molecule] expression and neutrophil integrin expressions of CD62L , , and CD11b in vitro . Regulation ICAM5 LIPG 18093422 1838162 To explore the relationship between human umbilical vascular endothelial cells ( HUVECs ) and , and the *effect* of EL on expression of endothelial cell adhesion molecule ( [ICAM] ) . Regulation ICAM5 SELL 11904622 923085 Nicotine exerts inhibitory *effects* on both endothelial cell surface [intercellular adhesion molecule] expression and neutrophil integrin expressions of , CD11a , and CD11b in vitro . Regulation ICAM5 TNF 1382639 198309 Exposure of HUVEC to perflubron did not alter the up-regulation of [ICAM] or ELAM in *response* to IL-1 or ( n = 20 ) . Regulation ICAM5 TNF 8100455 222552 Exposure of HUVEC to perflubron did not alter the upregulation of [ICAM] or ELAM in *response* to IL-1 or ( n = 20 ) . Regulation ICAM5 TNF 9830008 551263 We previously demonstrated that and H2O2 differentially *regulate* interleukin-8 (IL-8) and [intercellular adhesion molecule] ( ICAM-1 ) gene expression in endothelial and epithelial cells . Regulation ICOS EPHB2 16880206 1613760 *Regulation* of mouse [inducible costimulator (ICOS)] expression by Fyn-NFATc2 and signaling in T cells . Regulation ICOSLG TNF 11007762 735497 This ligand-receptor pair interacts with a K : ( D ) approximately 33 nM and an off-rate with a t ( ( 1/2 ) ) > 10 min. Interestingly , differentially *regulates* the expression of human [B7RP-1] on B cells , monocytes and dendritic cells ( DC ) . Regulation ID1 ATF3 18922905 1977380 In summary , we first showed that both and Smad were crucially and synergistically *involved* in down-regulation of [Id-1] , which regulated JNK phosphorylation in REIC/Dkk-3 induced apoptosis . Regulation ID1 BMP1 14656483 1177186 Furthermore , recent studies reveal an important effector function for [Id1] in various induced biological *responses* . Regulation ID1 BMP1 20181926 2242841 These data suggest a model in which signaling *regulates* [Id1] and Id3 in muscle satellite cells , which directs their proper proliferation before terminal myogenic differentiation after skeletal muscle injury in postnatal animals . Regulation ID1 BMP10 14656483 1177194 Furthermore , recent studies reveal an important effector function for [Id1] in various induced biological *responses* . Regulation ID1 BMP10 20181926 2242849 These data suggest a model in which signaling *regulates* [Id1] and Id3 in muscle satellite cells , which directs their proper proliferation before terminal myogenic differentiation after skeletal muscle injury in postnatal animals . Regulation ID1 BMP15 14656483 1177187 Furthermore , recent studies reveal an important effector function for [Id1] in various induced biological *responses* . Regulation ID1 BMP15 20181926 2242842 These data suggest a model in which signaling *regulates* [Id1] and Id3 in muscle satellite cells , which directs their proper proliferation before terminal myogenic differentiation after skeletal muscle injury in postnatal animals . Regulation ID1 BMP2 14656483 1177188 Furthermore , recent studies reveal an important effector function for [Id1] in various induced biological *responses* . Regulation ID1 BMP2 15192043 1280959 Although Id-1 response was not stimulated by BMP-2 in control PASMCs , the gene delivery of wild-type ALK-6 caused significant increase in the [Id-1] transcripts in *response* to . Regulation ID1 BMP2 20181926 2242843 These data suggest a model in which signaling *regulates* [Id1] and Id3 in muscle satellite cells , which directs their proper proliferation before terminal myogenic differentiation after skeletal muscle injury in postnatal animals . Regulation ID1 BMP2 20639315 2322051 Pretreatment of cultured granulosa with rh NOG reversed both the stimulatory *effects* of on [ID1] , ID3 , and ID4 expression and the inhibitory effects of BMP2 on FSHR mRNA levels and progesterone production . Regulation ID1 BMP3 14656483 1177189 Furthermore , recent studies reveal an important effector function for [Id1] in various induced biological *responses* . Regulation ID1 BMP3 20181926 2242844 These data suggest a model in which signaling *regulates* [Id1] and Id3 in muscle satellite cells , which directs their proper proliferation before terminal myogenic differentiation after skeletal muscle injury in postnatal animals . Regulation ID1 BMP4 14656483 1177190 Furthermore , recent studies reveal an important effector function for [Id1] in various induced biological *responses* . Regulation ID1 BMP4 20181926 2242845 These data suggest a model in which signaling *regulates* [Id1] and Id3 in muscle satellite cells , which directs their proper proliferation before terminal myogenic differentiation after skeletal muscle injury in postnatal animals . Regulation ID1 BMP5 14656483 1177191 Furthermore , recent studies reveal an important effector function for [Id1] in various induced biological *responses* . Regulation ID1 BMP5 20181926 2242846 These data suggest a model in which signaling *regulates* [Id1] and Id3 in muscle satellite cells , which directs their proper proliferation before terminal myogenic differentiation after skeletal muscle injury in postnatal animals . Regulation ID1 BMP6 14656483 1177192 Furthermore , recent studies reveal an important effector function for [Id1] in various induced biological *responses* . Regulation ID1 BMP6 18072288 1854371 We next examined the *effects* of on the downstream gene [Id-1] in a cohort of prostate cancer patients . Regulation ID1 BMP6 20181926 2242847 These data suggest a model in which signaling *regulates* [Id1] and Id3 in muscle satellite cells , which directs their proper proliferation before terminal myogenic differentiation after skeletal muscle injury in postnatal animals . Regulation ID1 BMP7 14656483 1177193 Furthermore , recent studies reveal an important effector function for [Id1] in various induced biological *responses* . Regulation ID1 BMP7 20181926 2242848 These data suggest a model in which signaling *regulates* [Id1] and Id3 in muscle satellite cells , which directs their proper proliferation before terminal myogenic differentiation after skeletal muscle injury in postnatal animals . Regulation ID1 CALM3 23985211 2836307 To verify whether abnormal expression of *dependent* serine protein kinase ( CASK ) and [inhibitors of differentiation 1 (ID1)] exist in Fb of keloid , and to observe the effect of artesunate on two genes . Regulation ID1 CCND1 15489884 1359461 These data indicate that in mammary epithelial cells , Id1 has cell cycle regulatory functions that are similar to those of c-Myc , and suggest that may be *involved* in [Id1] regulation of cell cycle progression . Regulation ID1 CEBPA 22568493 2619211 We have shown that *regulates* [ID1] expression . Regulation ID1 EGR1 21506108 2418463 Induction of [Id-1] by FGF-2 *involves* activity of and sensitizes neuroblastoma cells to cell death . Regulation ID1 EPC1 18092003 1838106 However , the manner in which [Id1] loss in the BM *controls* generation or mobilization is largely unknown . Regulation ID1 EPC2 18092003 1838107 However , the manner in which [Id1] loss in the BM *controls* generation or mobilization is largely unknown . Regulation ID1 FGF2 21506108 2418466 Although regulation of Id-1 protein by several mitogenic factors is well established , little is known about the *role* of in the regulation of [Id-1] . Regulation ID1 ID2 23397264 2809611 This study shows that [Id1] expression in endothelial cells may contribute to angiogenic processes and that increased expression of and Id3 in medulloblastoma is potentially *involved* in tumor cell proliferation and survival . Regulation ID1 ID2 9779825 540442 These data support a cell-cycle regulatory role for [Id-1] in multipotent myeloid progenitor cells and a *role* for during terminal granulocytic differentiation . Regulation ID1 ID3 18456300 1921355 Neither Id1 nor was sufficient to transform Rat-1 cells and inhibition of [Id1] expression did not *affect* LMP1 induced morphologic transformation of Rat-1 cells or reduction of p27 . Regulation ID1 ID3 23397264 2809612 This study shows that [Id1] expression in endothelial cells may contribute to angiogenic processes and that increased expression of Id2 and in medulloblastoma is potentially *involved* in tumor cell proliferation and survival . Regulation ID1 IGF1 12061821 952928 *Regulation* of [Id1] protein expression in mouse embryo fibroblasts by the type 1 receptor . Regulation ID1 LEP 12604508 1085093 We investigated the *effect* of acute cold exposure , , and the somatostatin analog octreotide ( OCT ) on thyroid type [I (D1)] and II ( D2 ) deiodinase activities . Regulation ID1 MAPK1 23867624 2821323 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and signaling and [ID1] gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation ID1 MAPK10 23867624 2821324 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and signaling and [ID1] gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation ID1 MAPK11 23867624 2821325 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and signaling and [ID1] gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation ID1 MAPK12 23867624 2821326 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and signaling and [ID1] gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation ID1 MAPK13 23867624 2821327 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and signaling and [ID1] gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation ID1 MAPK14 23867624 2821328 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and signaling and [ID1] gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation ID1 MAPK15 23867624 2821322 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and signaling and [ID1] gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation ID1 MAPK3 18436795 1915409 Thus , BMP4 induced [Id1] expression was negatively *regulated* by activation . Regulation ID1 MAPK3 23867624 2821329 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and signaling and [ID1] gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation ID1 MAPK4 23867624 2821330 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and signaling and [ID1] gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation ID1 MAPK6 23867624 2821331 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and signaling and [ID1] gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation ID1 MAPK7 23867624 2821332 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and signaling and [ID1] gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation ID1 MAPK8 23867624 2821333 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and signaling and [ID1] gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation ID1 MAPK9 23867624 2821334 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and signaling and [ID1] gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation ID1 MCAM 21467165 2428092 Expression of [Id-1] is *regulated* by : a missing link in melanoma progression . Regulation ID1 MCAM 21467165 2428095 To our knowledge , this is the first demonstration that is *involved* in cell signaling regulating the expression of [Id-1] and ATF-3 , thus contributing to melanoma metastasis . Regulation ID1 ME2 16585173 1544120 We further show that [Id-1] expression is negatively *regulated* by <2ME(2)> , which may be an additional mechanism for the antiangiogenic effect of 2ME(2) . Regulation ID1 MT1IP 23701823 2806108 Among the MT1R signaling pathways including AKT , ERK and JNK pathways , inhibition of AKT signaling functionally reversed the *effects* on both CRH induced POMC transcription and BMP-4 induced [Id-1] transcription . Regulation ID1 PSEN1 19920078 2171792 can *control* [Id1] , which affects satellite cell fate by regulating the transcriptional activity of MyoD . Regulation ID1 SKP2 24177224 2868315 Furthermore , Skp2 regulated [Id1] expression by regulating Myc activity , and the regulation of is *involved* in the activity of p16 promoter through regulation of Id1 expression . Regulation ID1 SMAD1 11729207 904443 BMP , but not TGF-beta , strongly activates the [Id1] promoter in an *dependent* manner . Regulation ID1 SMAD1 17579118 1763961 *dependent* [inhibitor of DNA binding 1] expression and Smad2/3 dependent plasminogen activator inhibitor I expression both were decreased and were accompanied by decreased cell proliferation . Regulation ID1 SMAD1 18922905 1977372 In summary , we first showed that both ATF3 and were crucially and synergistically *involved* in down-regulation of [Id-1] , which regulated JNK phosphorylation in REIC/Dkk-3 induced apoptosis . Regulation ID1 SMAD2 11729207 904444 BMP , but not TGF-beta , strongly activates the [Id1] promoter in an *dependent* manner . Regulation ID1 SMAD2 18922905 1977373 In summary , we first showed that both ATF3 and were crucially and synergistically *involved* in down-regulation of [Id-1] , which regulated JNK phosphorylation in REIC/Dkk-3 induced apoptosis . Regulation ID1 SMAD3 11729207 904445 BMP , but not TGF-beta , strongly activates the [Id1] promoter in an *dependent* manner . Regulation ID1 SMAD3 18922905 1977374 In summary , we first showed that both ATF3 and were crucially and synergistically *involved* in down-regulation of [Id-1] , which regulated JNK phosphorylation in REIC/Dkk-3 induced apoptosis . Regulation ID1 SMAD3 19798702 2186984 Transforming growth factor-beta suppressed [Id-1] Expression in a *dependent* manner in LoVo cells . Regulation ID1 SMAD3 19798702 2187003 In conclusion , this study demonstrated that TGF-beta1 suppressed [Id-1] expression in a *dependent* manner in LoVo cells using RNAi technology . Regulation ID1 SMAD4 11729207 904446 BMP , but not TGF-beta , strongly activates the [Id1] promoter in an *dependent* manner . Regulation ID1 SMAD4 18922905 1977375 In summary , we first showed that both ATF3 and were crucially and synergistically *involved* in down-regulation of [Id-1] , which regulated JNK phosphorylation in REIC/Dkk-3 induced apoptosis . Regulation ID1 SMAD5 11729207 904447 BMP , but not TGF-beta , strongly activates the [Id1] promoter in an *dependent* manner . Regulation ID1 SMAD5 17579118 1763962 *dependent* [inhibitor of DNA binding 1] expression and Smad2/3 dependent plasminogen activator inhibitor I expression both were decreased and were accompanied by decreased cell proliferation . Regulation ID1 SMAD5 18922905 1977376 In summary , we first showed that both ATF3 and were crucially and synergistically *involved* in down-regulation of [Id-1] , which regulated JNK phosphorylation in REIC/Dkk-3 induced apoptosis . Regulation ID1 SMAD6 11729207 904448 BMP , but not TGF-beta , strongly activates the [Id1] promoter in an *dependent* manner . Regulation ID1 SMAD6 18922905 1977377 In summary , we first showed that both ATF3 and were crucially and synergistically *involved* in down-regulation of [Id-1] , which regulated JNK phosphorylation in REIC/Dkk-3 induced apoptosis . Regulation ID1 SMAD7 11729207 904449 BMP , but not TGF-beta , strongly activates the [Id1] promoter in an *dependent* manner . Regulation ID1 SMAD7 18922905 1977378 In summary , we first showed that both ATF3 and were crucially and synergistically *involved* in down-regulation of [Id-1] , which regulated JNK phosphorylation in REIC/Dkk-3 induced apoptosis . Regulation ID1 SMAD9 11729207 904450 BMP , but not TGF-beta , strongly activates the [Id1] promoter in an *dependent* manner . Regulation ID1 SMAD9 18922905 1977379 In summary , we first showed that both ATF3 and were crucially and synergistically *involved* in down-regulation of [Id-1] , which regulated JNK phosphorylation in REIC/Dkk-3 induced apoptosis . Regulation ID1 SP1 16638616 1671907 *Involvement* of in the regulation of the [Id-1] gene during trophoblast cell differentiation . Regulation ID1 SRC 18381431 1892882 *Regulation* of [Id1] expression by : implications for targeting of the bone morphogenetic protein pathway in cancer . Regulation ID1 SRC 20709421 2388910 As shown recently , [ID1] is positively *regulated* by the tyrosine kinase in lung carcinoma cell lines and with that appears as a potential new therapeutic target in non-small cell carcinoma ( NSCLC ) . Regulation ID1 TGFB1 19079362 2018274 Our results demonstrate that Smad3 , but not Smad2 , mediates *dependent* early transcriptional induction of [Id1] . Regulation ID1 TGM2 23877317 2844469 Further studies indicated that expression of [inhibitor of DNA binding 1 protein (ID1)] is *regulated* by and might be an important mediator for TGM2 regulated cell proliferation in CD44-high glioma initiating cell lines . Regulation ID1 TGM2 23877317 2844471 *regulates* [ID1] expression in glioma initiating cell lines high in CD44 . Regulation ID1 TP53 18556654 1946102 Here , we showed that [ID1] is down-regulated in cells treated with various DNA damage agents in a *dependent* manner . Regulation ID2 ID1 9779825 540443 These data support a cell-cycle regulatory role for in multipotent myeloid progenitor cells and a *role* for [Id-2] during terminal granulocytic differentiation . Regulation ID3 ID1 18456300 1921356 Neither Id1 nor [Id3] was sufficient to transform Rat-1 cells and inhibition of expression did not *affect* LMP1 induced morphologic transformation of Rat-1 cells or reduction of p27 . Regulation IDDM10 FAS 11321233 807041 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Regulation IDDM10 TNF 10436260 634543 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Regulation IDDM10 TNF 9685802 521736 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Regulation IDDM11 FAS 11321233 807043 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Regulation IDDM11 TNF 10436260 634544 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Regulation IDDM11 TNF 9685802 521737 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Regulation IDDM12 FAS 11321233 807045 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Regulation IDDM12 TNF 10436260 634545 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Regulation IDDM12 TNF 9685802 521738 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Regulation IDDM13 FAS 11321233 807047 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Regulation IDDM13 TNF 10436260 634546 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Regulation IDDM13 TNF 9685802 521739 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Regulation IDDM14 FAS 11321233 807049 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Regulation IDDM14 TNF 10436260 634547 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Regulation IDDM14 TNF 9685802 521740 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Regulation IDDM15 FAS 11321233 807051 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Regulation IDDM15 TNF 10436260 634548 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Regulation IDDM15 TNF 9685802 521741 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Regulation IDDM16 FAS 11321233 807053 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Regulation IDDM16 TNF 10436260 634549 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Regulation IDDM16 TNF 9685802 521742 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Regulation IDDM17 FAS 11321233 807055 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Regulation IDDM17 TNF 10436260 634550 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Regulation IDDM17 TNF 9685802 521743 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Regulation IDDM18 FAS 11321233 807057 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Regulation IDDM18 TNF 10436260 634551 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Regulation IDDM18 TNF 9685802 521744 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Regulation IDDM2 FAS 11321233 807059 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Regulation IDDM2 TNF 10436260 634552 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Regulation IDDM2 TNF 9685802 521745 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Regulation IDDM3 FAS 11321233 807061 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Regulation IDDM3 TNF 10436260 634553 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Regulation IDDM3 TNF 9685802 521746 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Regulation IDDM4 FAS 11321233 807063 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Regulation IDDM4 TNF 10436260 634554 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Regulation IDDM4 TNF 9685802 521747 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Regulation IDDM5 FAS 11321233 807065 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Regulation IDDM5 TNF 10436260 634555 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Regulation IDDM5 TNF 9685802 521748 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Regulation IDDM6 FAS 11321233 807067 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Regulation IDDM6 TNF 10436260 634556 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Regulation IDDM6 TNF 9685802 521749 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Regulation IDDM7 FAS 11321233 807069 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Regulation IDDM7 TNF 10436260 634557 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Regulation IDDM7 TNF 9685802 521750 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Regulation IDDM8 FAS 11321233 807071 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Regulation IDDM8 TNF 10436260 634558 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Regulation IDDM8 TNF 9685802 521751 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Regulation IDDM9 FAS 11321233 807073 The *role* of in CD8+ T-cell mediated [insulin dependent diabetes mellitus] ( IDDM ) . Regulation IDDM9 TNF 10436260 634559 However , the *role* of soluble receptors in [insulin dependent diabetes mellitus] ( type 1 DM ) is not clear . Regulation IDDM9 TNF 9685802 521752 The present paper summarizes the data ( including the authors ' observations as well ) focusing on the potential *role* of in the pathogenesis of obesity and [non-insulin dependent diabetes mellitus] : alteration of insulin receptor function , lipid metabolism , expression of sulphonylurea receptors , all of them suggested to be related to the TNF-alpha . Regulation IDE NES 19584300 2149735 The binding of IDE to either or phosphorylated vimentin *regulates* [IDE] activity differently , depending on the substrate . Regulation IDO1 CAPN8 21075457 2395659 *Regulation* of Th1/Th17 cytokines and [IDO] gene expression by inhibition of in PBMCs from MS patients . Regulation IDO1 TNF 10805371 691962 Our objectives were to characterize the antichlamydial *effect* of on IFN induced [IDO] activity and to establish the relationship between LPS and TNF-alpha in IDO potentiation . Regulation IDO1 TNF 10805371 691965 Anti-TNF-alpha failed to neutralize the effects of LPS treatment , and insufficient TNF-alpha or IL-1 was produced by LPS treated THP-1 cells to account for the enhancing effect of LPS , indicating that the effect of LPS on [IDO] was *independent* of and IL-1 . Regulation IER3 SLC38A3 17704804 1866005 Quantitative real-time PCR and conventional RT-PCR confirmed this *dependent* increase of [IEX-1] expression in Colo320wt cells . Regulation IER3 TNF 19885854 2188228 Transcriptional *regulation* of [IER3IP1] gene by and Sp family proteins . Regulation IER3 TNF 22417305 2572672 CD4+ CD26- lymphocytes from the peripheral blood of patients with SzS and healthy controls were negatively selected using CD4 and CD26 magnetic beads and analysed for expression of TNFR1 , TNFR2 , [IER3] expression , and ROS production in *response* to at an apoptotic dose . Regulation IER3 TNF 8603392 352169 Cells depleted of PKC by prolonged incubation with TPA showed no attenuated [IEX-1] *response* to . Regulation IFI27 AHR 15077192 1251856 As shown for TCDD ( dioxin ) , this effect appears to be mediated through the *dependent* expression of [p27] ( KIP1 ) . Regulation IFI27 AKT1 11546775 868983 *Involvement* of kinase B in up-regulation of p21 ( WAF1/CIP1 ) but not [p27] ( KIP1 ) . Regulation IFI27 AKT1 15930366 1414551 Furthermore , ABT-100 inhibited *dependent* [p27] ( Kip1 ) phosphorylation and this event was associated with increased levels of p27 ( Kip1 ) in the nucleus and reduced activity of the cyclin dependent kinase 2 . Regulation IFI27 AKT1 16425184 1540275 signaling *regulates* [p27] ( kip1 ) expression via Skp2 in PC3 and DU145 prostate cancer cells , but is not a major factor in p27 ( kip1 ) regulation in LNCaP and PC346 cells . Regulation IFI27 AKT1 17059763 1637157 might *play* a role in the cytoplasmic localization of [P27] , but has no correlation to its nuclear expression . Regulation IFI27 AKT1 17533372 1822068 Using DNA damage as a p27 nuclear import signal , we found that the E7 oncoprotein from human papillomavirus type 16 ( HPV-16 ) , the etiological agent of cervical cancer , enhanced both the cytoplasmic retention of [p27] and the migration of human foreskin keratinocytes ( HFKs ) in a phosphoinositide-3 kinase <(PI3K)/Akt> *dependent* manner using a standard wound assay . Regulation IFI27 AKT2 11546775 868984 *Involvement* of kinase B in up-regulation of p21 ( WAF1/CIP1 ) but not [p27] ( KIP1 ) . Regulation IFI27 AKT2 15930366 1414552 Furthermore , ABT-100 inhibited *dependent* [p27] ( Kip1 ) phosphorylation and this event was associated with increased levels of p27 ( Kip1 ) in the nucleus and reduced activity of the cyclin dependent kinase 2 . Regulation IFI27 AKT2 16425184 1540276 signaling *regulates* [p27] ( kip1 ) expression via Skp2 in PC3 and DU145 prostate cancer cells , but is not a major factor in p27 ( kip1 ) regulation in LNCaP and PC346 cells . Regulation IFI27 AKT2 17059763 1637158 might *play* a role in the cytoplasmic localization of [P27] , but has no correlation to its nuclear expression . Regulation IFI27 AKT2 17533372 1822069 Using DNA damage as a p27 nuclear import signal , we found that the E7 oncoprotein from human papillomavirus type 16 ( HPV-16 ) , the etiological agent of cervical cancer , enhanced both the cytoplasmic retention of [p27] and the migration of human foreskin keratinocytes ( HFKs ) in a phosphoinositide-3 kinase <(PI3K)/Akt> *dependent* manner using a standard wound assay . Regulation IFI27 AKT3 11546775 868985 *Involvement* of kinase B in up-regulation of p21 ( WAF1/CIP1 ) but not [p27] ( KIP1 ) . Regulation IFI27 AKT3 15930366 1414553 Furthermore , ABT-100 inhibited *dependent* [p27] ( Kip1 ) phosphorylation and this event was associated with increased levels of p27 ( Kip1 ) in the nucleus and reduced activity of the cyclin dependent kinase 2 . Regulation IFI27 AKT3 16425184 1540277 signaling *regulates* [p27] ( kip1 ) expression via Skp2 in PC3 and DU145 prostate cancer cells , but is not a major factor in p27 ( kip1 ) regulation in LNCaP and PC346 cells . Regulation IFI27 AKT3 17059763 1637159 might *play* a role in the cytoplasmic localization of [P27] , but has no correlation to its nuclear expression . Regulation IFI27 AKT3 17533372 1822070 Using DNA damage as a p27 nuclear import signal , we found that the E7 oncoprotein from human papillomavirus type 16 ( HPV-16 ) , the etiological agent of cervical cancer , enhanced both the cytoplasmic retention of [p27] and the migration of human foreskin keratinocytes ( HFKs ) in a phosphoinositide-3 kinase <(PI3K)/Akt> *dependent* manner using a standard wound assay . Regulation IFI27 ANGPT2 11715452 581252 had no *effect* on [P27] expression in both VSMCs and CMs . Regulation IFI27 ANXA6 15166254 1288305 These data suggest that TSH regulates cell cycle progression , in part , by increasing the number of cycling cells through mediated *effects* on the localization of [p27] . Regulation IFI27 APOB 10743236 478655 [ *Effect* of on cell cycling phases and PCNA , P53 , [P27] and c-erbB-2 expression in cultured human arterial smooth muscle cells ] . Regulation IFI27 APOE 23294923 2737836 Moreover , reconstituted miR222 expression was sufficient to override the *effects* of on [p27] expression and S phase entry . Regulation IFI27 BMP2 12850001 1109214 We found a significant accumulation of [p27] ( KIP1 ) in *response* to , whereas the expression level of Skp2 , which is required for ubiquitin dependent p27 ( KIP1 ) degradation , was decreased during this differentiation process . Regulation IFI27 CASP1 12429803 1015056 These findings suggest that ( SKP2 ) is *involved* in Kaposi 's sarcoma progression , not only by promoting the degradation of [p27] ( KIP1 ) but also through other mechanisms still unknown . Regulation IFI27 CASP1 15059916 1230426 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Regulation IFI27 CASP10 15059916 1230427 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Regulation IFI27 CASP12 15059916 1230437 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Regulation IFI27 CASP14 15059916 1230428 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Regulation IFI27 CASP16 15059916 1230438 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Regulation IFI27 CASP2 15059916 1230429 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Regulation IFI27 CASP3 15059916 1230430 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Regulation IFI27 CASP4 15059916 1230431 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Regulation IFI27 CASP5 15059916 1230432 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Regulation IFI27 CASP6 15059916 1230433 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Regulation IFI27 CASP7 15059916 1230434 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Regulation IFI27 CASP8 15059916 1230435 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Regulation IFI27 CASP9 15059916 1230436 It was also accompanied by the *dependent* down-regulation of [p27] ( KIP1 ) , cyclins A , E , and D ( 1 ) , and cleavage and diminished phosphorylation of retinoblastoma protein . Regulation IFI27 CCL5 21130742 2372831 Cxcl10 , Mx1 , Ifi44 , [Ifi203] , Iigp2 and Rtp4 were dominantly *regulated* by IPS-1 , by TLR3 , and Rsad2 , Mx2 and Cmpk2 were regulated by TLR3 and IPS-1 . Regulation IFI27 CCNA2 10603039 575003 [p27/kip1] *regulates* the G1-S transition of the cell cycle by inhibiting cyclinD-CDK4 , cyclinE-CDK2 and complexes . Regulation IFI27 CCND1 10603039 575004 [p27/kip1] *regulates* the G1-S transition of the cell cycle by inhibiting , cyclinE-CDK2 and cyclinA-CDK2 complexes . Regulation IFI27 CCND1 17438373 1729261 Here , we show that PTEN negatively regulates expression of cyclin D1 and that *plays* a unique role in [p27] proteolysis . Regulation IFI27 CCND1 18006776 1827352 PPARgamma is overexpressed in ACHN cells and barely detectable in 786-0 cells , and treatment with DIM-C-pPhtBu induces proteasome dependent degradation of and variable *effects* on p21 and [p27] expression in both cell lines . Regulation IFI27 CCND1 20837141 2363747 *regulates* [p27] ( Kip1 ) stability in B cells . Regulation IFI27 CCND2 10603039 575005 [p27/kip1] *regulates* the G1-S transition of the cell cycle by inhibiting , cyclinE-CDK2 and cyclinA-CDK2 complexes . Regulation IFI27 CCND3 10603039 575006 [p27/kip1] *regulates* the G1-S transition of the cell cycle by inhibiting , cyclinE-CDK2 and cyclinA-CDK2 complexes . Regulation IFI27 CCND3 9120257 423770 These data suggest that IL-4 controls B cell proliferation by action during at least two steps of the regulation of the cell cycle , complex *regulation* and [p27] inhibitor expression . Regulation IFI27 CCNE1 10603039 575007 [p27/kip1] *regulates* the G1-S transition of the cell cycle by inhibiting cyclinD-CDK4 , and cyclinA-CDK2 complexes . Regulation IFI27 CCNE1 16229012 1517953 Cell cycle progression is facilitated by *dependent* phosphorylation of [p27] on threonine 187 ( T187 ) during late G1 . Regulation IFI27 CCNE2 10603039 575008 [p27/kip1] *regulates* the G1-S transition of the cell cycle by inhibiting cyclinD-CDK4 , and cyclinA-CDK2 complexes . Regulation IFI27 CD79A 9419166 480843 Induction of Th2 cytokine expression for [p27-specific] B cell *responses* after targeted lymph node immunization with simian immunodeficiency virus antigens in rhesus macaques . Regulation IFI27 CDH1 10023662 590657 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDH10 10023662 590658 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDH11 10023662 590659 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDH12 10023662 590660 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDH13 10023662 590661 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDH15 10023662 590662 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDH16 10023662 590663 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDH17 10023662 590664 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDH18 10023662 590665 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDH19 10023662 590666 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDH2 10023662 590667 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDH20 10023662 590668 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDH22 10023662 590653 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDH23 10023662 590654 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDH24 10023662 590655 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDH26 10023662 590656 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDH3 10023662 590669 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDH4 10023662 590670 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDH5 10023662 590671 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDH6 10023662 590672 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDH7 10023662 590673 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDH8 10023662 590674 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDH9 10023662 590675 We propose that mediated signaling is *involved* in contact inhibition of growth by inducing cell cycle arrest at the G1 phase and elevation of [p27] levels . Regulation IFI27 CDK2 10603039 575009 [p27/kip1] *regulates* the G1-S transition of the cell cycle by inhibiting cyclinD-CDK4 , and cyclinA-CDK2 complexes . Regulation IFI27 CDK2 16229012 1517954 Cell cycle progression is facilitated by *dependent* phosphorylation of [p27] on threonine 187 ( T187 ) during late G1 . Regulation IFI27 CDK2 22223646 2559099 In mammalian cells activity during the G ( 1 ) -S transition is mainly *controlled* by [p27] ( KIP1 ) . Regulation IFI27 CDK2 22584582 2614300 During the G ( 1 ) -S transition , the activity of Cdk2 is *regulated* by its association with [p27] ( KIP1 ) , which in rodent fibroblasts undergoes phosphorylation mainly at serine 10 , threonine 187 , and C-terminal threonine 197 by KIS , , and Pim or ROCK , respectively . Regulation IFI27 CDK2 9399644 469208 *dependent* phosphorylation of [p27] facilitates its Myc induced release from cyclin E/cdk2 complexes . Regulation IFI27 CDK4 10603039 575010 [p27/kip1] *regulates* the G1-S transition of the cell cycle by inhibiting , cyclinE-CDK2 and cyclinA-CDK2 complexes . Regulation IFI27 CDKN2A 19858485 2165562 Furthermore , we show that the roles of p16(Ink4a) and p27 ( Kip1 ) in the control of contact inhibition became temporally separated in this species : the early contact inhibition is controlled by , and regular contact inhibition is *controlled* by [p27] ( Kip1 ) . Regulation IFI27 CFL1 19556892 2117176 These data suggest that expression and its *regulation* of [p27] ( kip1 ) expression is important for the control of G ( 1 ) phase progression . Regulation IFI27 CFL2 19556892 2117177 These data suggest that expression and its *regulation* of [p27] ( kip1 ) expression is important for the control of G ( 1 ) phase progression . Regulation IFI27 CIB1 19819988 2154608 BMP-4 induction of arrest and differentiation of osteoblast-like cells via p21 CIP1 and [p27] *regulation* . Regulation IFI27 CKS1B 14654553 1173925 These findings indicate that , as well as Skp2 , *regulates* the expression level of [p27] protein in gastric carcinomas . Regulation IFI27 CKS1B 22017545 2498878 These data suggest that both Skp2 and are up-regulated by the TNFa-RelB/p52 pathway in the early stages of renal damage and are collaboratively *involved* in down-regulation of [p27] in proliferative tubular dilation and the progression of chronic nephropathy . Regulation IFI27 COPS5 22350412 2576576 negatively *regulates* [p27] and plays a role in the pathogenesis of nasopharyngeal carcinoma . Regulation IFI27 CTGF 16790529 1590937 moreover , addition of the Akt/PKB inhibitor interleukin (IL)-6-hydroxymethyl-chiro-inositol-2 ( R ) -2-methyl-3-O-octadecylcarbonate prevented [p27] ( Kip-1 ) phosphorylation in *response* to . Regulation IFI27 CTTN 20805359 2330626 *regulated* expression of p21 ( WAF1/Cip1 ) and [p27] ( Kip1 ) at the transcriptional and posttranscriptional levels , respectively . Regulation IFI27 DCN 11567999 864117 Furthermore , increases macrophage adhesion to the extracellular matrix , and this may be partially *responsible* for the expression of [p27] ( Kip1 ) and the modification of ERK activity , but not for the increased cell survival . Regulation IFI27 EIF3A 23437357 2744607 Additionally , eIF3a positively regulated proliferation , but negatively regulated cell motility and invasion , which may be due to the *dependent* changes in expression of NDRG1 and [p27] ( kip1 ) observed under these conditions . Regulation IFI27 FOXM1 12221098 1012218 Furthermore , we found that restoring FoxM1B expression did not influence p27 mRNA levels , and this new finding implicates in *regulation* of [p27] protein levels . Regulation IFI27 FOXO1 15087469 1258121 These studies demonstrate for the first time that can *regulate* [p27kip] nuclear localization . Regulation IFI27 FOXO1 23077062 2690087 Cdk2 activation was essential for the regenerative OPC response after hypoxia and was accompanied by reduced *dependent* [p27] ( Kip1 ) expression . Regulation IFI27 FOXO3 24441545 2922841 Mechanisms in cardiac fibroblast growth : an obligate *role* for Skp2 and in ERK1/2 MAPK dependent regulation of [p27kip1] . Regulation IFI27 GATA2 12393444 1007907 These results suggest that may *regulate* expression levels of p21 ( WAF1 ) and [p27] ( Kip1 ) , thereby contributing to the quiescence of hematopoietic stem/progenitor cells . Regulation IFI27 HCL1 20818264 2336424 We assessed the *effects* of bile acid , , and eosinophil granule proteins on [p27] protein expression , localization , and its ability to regulate cell proliferation . Regulation IFI27 HCL2 20818264 2336425 We assessed the *effects* of bile acid , , and eosinophil granule proteins on [p27] protein expression , localization , and its ability to regulate cell proliferation . Regulation IFI27 HCL3 20818264 2336426 We assessed the *effects* of bile acid , , and eosinophil granule proteins on [p27] protein expression , localization , and its ability to regulate cell proliferation . Regulation IFI27 ID3 17404577 1777805 Apart from its effect on the early p27 diminution , appears also *involved* in the control of the steady-state level of [p27] at the G1/S boundary . Regulation IFI27 IFNA1 18329281 1891937 Also , the up-regulation of [ISG12A] was *independent* of the receptor 2 , but dependent on STAT1 . Regulation IFI27 IFNA10 18329281 1891938 Also , the up-regulation of [ISG12A] was *independent* of the receptor 2 , but dependent on STAT1 . Regulation IFI27 IFNA13 18329281 1891939 Also , the up-regulation of [ISG12A] was *independent* of the receptor 2 , but dependent on STAT1 . Regulation IFI27 IFNA14 18329281 1891940 Also , the up-regulation of [ISG12A] was *independent* of the receptor 2 , but dependent on STAT1 . Regulation IFI27 IFNA16 18329281 1891941 Also , the up-regulation of [ISG12A] was *independent* of the receptor 2 , but dependent on STAT1 . Regulation IFI27 IFNA17 18329281 1891942 Also , the up-regulation of [ISG12A] was *independent* of the receptor 2 , but dependent on STAT1 . Regulation IFI27 IFNA2 18329281 1891943 Also , the up-regulation of [ISG12A] was *independent* of the receptor 2 , but dependent on STAT1 . Regulation IFI27 IFNA21 18329281 1891944 Also , the up-regulation of [ISG12A] was *independent* of the receptor 2 , but dependent on STAT1 . Regulation IFI27 IFNA4 18329281 1891945 Also , the up-regulation of [ISG12A] was *independent* of the receptor 2 , but dependent on STAT1 . Regulation IFI27 IFNA5 18329281 1891946 Also , the up-regulation of [ISG12A] was *independent* of the receptor 2 , but dependent on STAT1 . Regulation IFI27 IFNA6 18329281 1891947 Also , the up-regulation of [ISG12A] was *independent* of the receptor 2 , but dependent on STAT1 . Regulation IFI27 IFNA7 18329281 1891948 Also , the up-regulation of [ISG12A] was *independent* of the receptor 2 , but dependent on STAT1 . Regulation IFI27 IFNA8 18329281 1891949 Also , the up-regulation of [ISG12A] was *independent* of the receptor 2 , but dependent on STAT1 . Regulation IFI27 KANK2 21734459 2471772 *regulates* [p27] ( kip1 ) stability and cell migration under metabolic stress . Regulation IFI27 KLF4 18559508 1923992 Overexpression of KLF4 also led to significant induction of p27 ( Kip1 ) expression , at both the RNA and protein levels , in a dose- and time dependent manner , indicating that transcriptionally *regulates* the expression of [p27] ( Kip1 ) . Regulation IFI27 LAMB2 20608352 2286369 To study the *effect* of on the expressions of PTEN and [P27kip1] in androgen independent prostate cancer PC-3 cells in vitro , and investigate the mechanism of its anti-tumor action . Regulation IFI27 MAPK1 21420505 2427220 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Regulation IFI27 MAPK1 24441545 2922842 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 dependent *regulation* of [p27kip1] . Regulation IFI27 MAPK10 18513991 1928408 These results suggest that the JNK pathway influences the stability of p27kip by phosphorylation of serine10 and that is *responsible* for the translational activation of [p27kip] protein expression in growth arrested C6 glioma cells and therefore cell cycle arrest . Regulation IFI27 MAPK10 21420505 2427221 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Regulation IFI27 MAPK10 24441545 2922843 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 *dependent* regulation of [p27kip1] . Regulation IFI27 MAPK11 21420505 2427222 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Regulation IFI27 MAPK11 24441545 2922844 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 dependent *regulation* of [p27kip1] . Regulation IFI27 MAPK12 21420505 2427223 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Regulation IFI27 MAPK12 24441545 2922845 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 *dependent* regulation of [p27kip1] . Regulation IFI27 MAPK13 21420505 2427224 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Regulation IFI27 MAPK13 24441545 2922846 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 dependent *regulation* of [p27kip1] . Regulation IFI27 MAPK14 21420505 2427225 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Regulation IFI27 MAPK14 24441545 2922847 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 *dependent* regulation of [p27kip1] . Regulation IFI27 MAPK15 21420505 2427219 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Regulation IFI27 MAPK15 24441545 2922840 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 *dependent* regulation of [p27kip1] . Regulation IFI27 MAPK3 21420505 2427226 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Regulation IFI27 MAPK3 24441545 2922848 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 dependent *regulation* of [p27kip1] . Regulation IFI27 MAPK4 21420505 2427227 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Regulation IFI27 MAPK4 24441545 2922849 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 *dependent* regulation of [p27kip1] . Regulation IFI27 MAPK6 21420505 2427228 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Regulation IFI27 MAPK6 24441545 2922850 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 dependent *regulation* of [p27kip1] . Regulation IFI27 MAPK7 21420505 2427229 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Regulation IFI27 MAPK7 24441545 2922851 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 *dependent* regulation of [p27kip1] . Regulation IFI27 MAPK8 21420505 2427230 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Regulation IFI27 MAPK8 24441545 2922852 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 dependent *regulation* of [p27kip1] . Regulation IFI27 MAPK9 21420505 2427231 [p27] induction in hypoxic cardiac fibroblasts may *involve* direct transcriptional regulation , independent of p38 , and post-translational regulation via p38 MAPK dependent suppression of its degradation by Skp2 . Regulation IFI27 MAPK9 24441545 2922853 Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 *dependent* regulation of [p27kip1] . Regulation IFI27 MAVS 21130742 2372833 Cxcl10 , Mx1 , Ifi44 , [Ifi203] , Iigp2 and Rtp4 were dominantly regulated by IPS-1 , Ccl5 by TLR3 , and Rsad2 , Mx2 and Cmpk2 were *regulated* by TLR3 and . Regulation IFI27 MIR221 21461636 2438526 post-transcriptional *regulation* of [P27KIP1] and P57KIP2 is crucial for high-glucose- and AGE mediated vascular cell damage . Regulation IFI27 MIR221 21461636 2438540 We provide evidence that high-glucose- and AGE induced inhibition of vascular cell proliferation is controlled by post-transcriptional *regulation* of [P27KIP1] and P57KIP2 . Regulation IFI27 MIR222 21461636 2438527 post-transcriptional *regulation* of [P27KIP1] and P57KIP2 is crucial for high-glucose- and AGE mediated vascular cell damage . Regulation IFI27 MIR222 21461636 2438541 We provide evidence that high-glucose- and AGE induced inhibition of vascular cell proliferation is controlled by post-transcriptional *regulation* of [P27KIP1] and P57KIP2 . Regulation IFI27 MYCN 12700651 1082055 Retinoic acid decreases targeting of p27 for degradation via an *dependent* decrease in [p27] phosphorylation and an N-myc independent decrease in Skp2 . Regulation IFI27 MYCN 12700651 1082058 *regulates* [p27] levels through an increase in targeting of p27 to the proteasome via cyclin E kinase dependent phosphorylation of p27 and its ubiquitination . Regulation IFI27 MYLIP 21355095 2415655 Furthermore , we provide evidence that indirectly *regulated* [p27] ( kip1 ) protein level by targeting Kip1 ubiquitination promoting complex 1 . Regulation IFI27 MYLIP 24955159 2947293 [P27] expression , other than p57 , was negatively *regulated* by overexpression at post-transcriptional level in HepG2 cells . Regulation IFI27 MYLK 12773570 1095230 The levels of cyclin E , cdk2 , and their major inhibitors , p21 ( cip1 ) and [p27] ( kip1 ) , were not *affected* by inhibition of or Rho kinase . Regulation IFI27 NPS 20236585 2223881 To evaluate the *effects* of rapamycin ( RPM ) -loaded poly ( lactic-co- glycolic ) acid ( PLGA ) on the proliferation , distribution of cell cycle , and expression of [p27] protein in human umbilical arterial vascular smooth muscle cell ( HUASMC ) in vitro . Regulation IFI27 NPS 20236585 2223882 The *effect* of RPM-PLGA on the expression of [p27] protein of HUASMCs was assessed through an immunohistochemical method . Regulation IFI27 OPN1MW 15297432 1283397 *Effects* of on expression of cell cycle-regulatory proteins p53 ( LNCaP only ) , p21 , and [p27] and the protein kinase Akt were considered using Western blot techniques . Regulation IFI27 PCNA 11557117 861257 [p27] , a cyclin dependent kinase inhibitor , *regulates* the progression from G1 into the S phase by binding and inhibiting . Regulation IFI27 PCNA 15073847 1232826 The essential *role* of in Skp2 dependent [p27] degradation was recently discovered , but its role in human malignancies is unknown . Regulation IFI27 PI3 12657588 1073259 Regulatory *role* of on expression of Cdk4 and [p27] , nuclear localization of Cdk4 , and phosphorylation of p27 in corneal endothelial cells . Regulation IFI27 PI3 17533372 1822071 Using DNA damage as a p27 nuclear import signal , we found that the E7 oncoprotein from human papillomavirus type 16 ( HPV-16 ) , the etiological agent of cervical cancer , enhanced both the cytoplasmic retention of [p27] and the migration of human foreskin keratinocytes ( HFKs ) in a *dependent* manner using a standard wound assay . Regulation IFI27 PIK3CA 16425184 1540278 signaling *regulates* [p27] ( kip1 ) expression via Skp2 in PC3 and DU145 prostate cancer cells , but is not a major factor in p27 ( kip1 ) regulation in LNCaP and PC346 cells . Regulation IFI27 PIK3R1 16425184 1540279 signaling *regulates* [p27] ( kip1 ) expression via Skp2 in PC3 and DU145 prostate cancer cells , but is not a major factor in p27 ( kip1 ) regulation in LNCaP and PC346 cells . Regulation IFI27 PIM1 22584582 2614301 During the G ( 1 ) -S transition , the activity of Cdk2 is *regulated* by its association with [p27] ( KIP1 ) , which in rodent fibroblasts undergoes phosphorylation mainly at serine 10 , threonine 187 , and C-terminal threonine 197 by KIS , Cdk2 , and or ROCK , respectively . Regulation IFI27 PPP2CA 20954073 2333481 In addition , ceramide stimulated binding of the PP2A catalytic subunit PP2A-Caß to Akt as assessed by immunoprecipitation experiments , indicating that is *involved* in the induction of [p27] ( kip1 ) via inhibition of Akt pathway . Regulation IFI27 PPP2R1A 20954073 2333482 In addition , ceramide stimulated binding of the PP2A catalytic subunit PP2A-Caß to Akt as assessed by immunoprecipitation experiments , indicating that is *involved* in the induction of [p27] ( kip1 ) via inhibition of Akt pathway . Regulation IFI27 PPP2R2B 20954073 2333483 In addition , ceramide stimulated binding of the PP2A catalytic subunit PP2A-Caß to Akt as assessed by immunoprecipitation experiments , indicating that is *involved* in the induction of [p27] ( kip1 ) via inhibition of Akt pathway . Regulation IFI27 PRDX2 10585285 571122 In the present study we have examined the *effect* of on members of the IGF axis , the CKIs p21 and [p27] , and also TGFbeta1 in Hep3B cells . Regulation IFI27 PTEN 17438373 1729262 Here , we show that negatively regulates expression of cyclin D1 and that cyclin D1 *plays* a unique role in [p27] proteolysis . Regulation IFI27 PTGS2 15645119 1363585 To clarify the pathological significance of COX-2 , we examined the *effect* of a selective inhibitor , NS398 , on two human gastric carcinoma cell lines , MKN-45 and KATO-III , and the expression of Skp2 , [P27/Kip1] and COX-2 protein in human gastric carcinomas . Regulation IFI27 RALA 11162603 782272 These results suggest that is *involved* in the Ras dependent anchorage independent growth of HT1080 cells by regulating [p27] ( Kip1 ) . Regulation IFI27 RALGAPB 12972576 1139553 The *effect* of on the synthesis of tyrosinated alpha-tubulin and [p27] in a reciprocal manner also suggests that p170 functions as a regulator for mRNA translation . Regulation IFI27 RENBP 21461636 2438542 We provide evidence that high-glucose- and induced inhibition of vascular cell proliferation is *controlled* by MIR221/MIR222-driven post-transcriptional regulation of [P27KIP1] and P57KIP2 . Regulation IFI27 RET 16953232 1682602 mediated *regulation* of p18 and [p27] , but not of cyclins D1 and D2 , requires functional mitogen activated protein kinase signaling . Regulation IFI27 ROCK1 22584582 2614298 During the G ( 1 ) -S transition , the activity of Cdk2 is *regulated* by its association with [p27] ( KIP1 ) , which in rodent fibroblasts undergoes phosphorylation mainly at serine 10 , threonine 187 , and C-terminal threonine 197 by KIS , Cdk2 , and Pim or , respectively . Regulation IFI27 ROCK2 22584582 2614299 During the G ( 1 ) -S transition , the activity of Cdk2 is *regulated* by its association with [p27] ( KIP1 ) , which in rodent fibroblasts undergoes phosphorylation mainly at serine 10 , threonine 187 , and C-terminal threonine 197 by KIS , Cdk2 , and Pim or , respectively . Regulation IFI27 S100A8 20934114 2332733 In this study , we try to determine *roles* of ( + ) strain in activating PI3K/Akt1 signaling pathway , and affecting expression of p21 ( WAF1/CIP1 ) and [p27] ( KIP1 ) , and also in releasing IL-8 in host cells . Regulation IFI27 SIAH1 21734459 2471771 *regulates* [p27] ( kip1 ) stability and cell migration under metabolic stress . Regulation IFI27 SKP2 14586067 1159423 These results suggest that *regulates* [p27] expression in Merkel cell carcinomas . Regulation IFI27 SKP2 15363035 1293887 Thus , and Jab1 *regulate* [P27] degradation , and might contribute to the development and progression of lung AD through P27 mediated and -unmediated mechanisms . Regulation IFI27 SKP2 17407140 1797750 Overexpression of integrin beta1 inhibits proliferation of hepatocellular carcinoma cell SMMC-7721 through preventing *dependent* degradation of [p27] via PI3K pathway . Regulation IFI27 SKP2 22017545 2498877 These data suggest that both and Cks1 are up-regulated by the TNFa-RelB/p52 pathway in the early stages of renal damage and are collaboratively *involved* in down-regulation of [p27] in proliferative tubular dilation and the progression of chronic nephropathy . Regulation IFI27 SKP2 22937180 2666957 The ubiquitin-ligase negatively *regulates* [p27] ( Kip1 ) and , during TIS , is translocated to the cytoplasm before its expression is decreased in senescent cells . Regulation IFI27 SKP2 23665265 2805509 P27 and , a major *regulator* of [P27] , play a crucial role in ovarian function in mice . Regulation IFI27 SKP2 24441545 2922839 Mechanisms in cardiac fibroblast growth : an obligate *role* for and FOXO3a in ERK1/2 MAPK dependent regulation of [p27kip1] . Regulation IFI27 SMAD3 17013388 1634078 Thus , [p27] ( Kip1 ) is required during induction of tolerance and *regulates* T cell responses ` downstream ' of p27 ( Kip1 ) . Regulation IFI27 SOCS1 15363035 1293888 Thus , Skp2 and *regulate* [P27] degradation , and might contribute to the development and progression of lung AD through P27 mediated and -unmediated mechanisms . Regulation IFI27 SOCS1 22350412 2576575 negatively *regulates* [p27] and plays a role in the pathogenesis of nasopharyngeal carcinoma . Regulation IFI27 SOCS1 22426400 2594292 also *plays* a major role in the degradation of the cyclin-dependent-kinase inhibitor and putative transcription cofactor [p27] ( Kip1 ) . Regulation IFI27 SRC 17254967 1691045 Here , we present data indicating that the oncogenic kinase *regulates* [p27] stability through phosphorylation of p27 at tyrosine 74 and tyrosine 88 . Regulation IFI27 TGFB1 9299547 453770 p21 mRNA expression was greatly induced by TGF-beta1 in a p53 independent mechanism , while [p27] mRNA expression was not *affected* by . Regulation IFI27 TLR3 21130742 2372832 Cxcl10 , Mx1 , Ifi44 , [Ifi203] , Iigp2 and Rtp4 were dominantly *regulated* by IPS-1 , Ccl5 by , and Rsad2 , Mx2 and Cmpk2 were regulated by TLR3 and IPS-1 . Regulation IFI27 TMED7 10022731 590134 These findings suggest that expression is regulated negatively by androgens and that increased expression of [p27] in CWR22 xenografts may be *involved* in the suppression of proliferation following castration . Regulation IFI27 TNF 21075101 2371464 *regulates* [p27] kip expression and apoptosis in smooth muscle cells of human carotid plaques via forkhead transcription factor O1 . Regulation IFI27 TNF 21075101 2371465 In this study , we examined the *effect* of on the cell cycle inhibitor [p27] ( kip ) and apoptosis of SMCs in human carotid plaques , and the underlying mechanism . Regulation IFI27 TNF 21075101 2371470 However , the potential *effect* of on the cell cycle inhibitor [p27] ( kip ) and apoptosis of SMCs was inhibited by siRNA against FoxO1 in asymptomatic patients . Regulation IFI27 TP53 11719966 883912 On the other hand , the accumulation of [p27] by hyperthermia was not seen in A-172 or U251 cells , and the exogenous expression of did not *affect* the accumulation of p27 by hyperthermia in U251 cells . Regulation IFI27 TP53 17143939 1653822 Troglitazone may induce p53 independent apoptosis and *dependent* expression of p21 and [p27] . Regulation IFI27 UBE3A 19591933 2130613 Our result suggests that not only enhances the degradation but also *regulates* the expression of [p27] and its loss of function in Angelman syndrome might cause cell cycle alteration leading to disease pathogenesis . Regulation IFI27 YY1 22440256 2588392 plays an essential role in breast cancer and negatively *regulates* [p27] . Regulation IFI44 CD14 7521366 269324 *dependent* activation of protein kinase C and mitogen activated protein kinases ( p42 and [p44] ) in human monocytes treated with bacterial lipopolysaccharide . Regulation IFI44 CD14 7561108 324192 Lipopolysaccharide stimulates the tyrosine phosphorylation of mitogen activated protein kinases [p44] , p42 , and p41 in vascular endothelial cells in a soluble *dependent* manner . Regulation IFI44 LBP 11134043 794923 Here we show that secretion of tumor necrosis factor-alpha induced by Treponema culture supernatants and extracted LTA was paralleled by an *dependent* phosphorylation of mitogen activated protein kinases ( MAPKs ) p42 and [p44] , and p38 , as well as the stress activated protein kinases c-Jun N-terminal kinases 1 and 2 . Regulation IFI44 MAP2K6 15064239 1231150 These results suggest that in HTSMCs , LTA stimulated [p42/p44] MAPK phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , , and PI 3-kinase . Regulation IFN1@ OASL 23874199 2817741 Herein , we explored whether <2'-5' oligoadenylate synthetase-like> 1 ( OASL1 ) , a recently defined [IFN-I] negative *regulator* , plays a key role in the virus-specific T-cell response and viral defense against chronic LCMV . Regulation IFN1@ OASL 23874199 2817744 Together , these results demonstrate that mediated negative *regulation* of [IFN-I] production at an early phase of infection permits viral persistence and suppresses T-cell function , suggesting that IFN-I negative regulators , including OASL1 , could be exciting new targets for preventing chronic viral infection . Regulation IFN1@ TLR7 24586760 2920226 The immunoglobulin-like transcript (ILT)7 is a surface receptor expressed by immature pDC , and ILT7 cross linking ( XL-ILT7 ) inhibits [IFN-I] production by pDC in *response* to and 9 stimulation . Regulation IFNA1 TLR7 18806803 1969820 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Regulation IFNA1 TLR7 19597505 2117986 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Regulation IFNA1 TLR7 24009514 2836825 In 2008 it was reported that plasmacytoid dendritic cells ( pDCs ) of SMs exhibit attenuated [interferon-alpha] ( IFN-a ) *responses* to ligands in vitro , and that species-specific amino acid substitutions in SM Interferon Regulatory Factor-7 (IRF7) are responsible for this observation . Regulation IFNA1 TNF 9555981 499233 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the [interferon (IFN)-alpha] , IFN-beta , interleukin-6 (IL-6) , and *response* to NDV but not to Sendai virus . Regulation IFNA10 TLR7 18806803 1969821 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Regulation IFNA10 TLR7 19597505 2117987 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Regulation IFNA10 TLR7 24009514 2836826 In 2008 it was reported that plasmacytoid dendritic cells ( pDCs ) of SMs exhibit attenuated [interferon-alpha] ( IFN-a ) *responses* to ligands in vitro , and that species-specific amino acid substitutions in SM Interferon Regulatory Factor-7 (IRF7) are responsible for this observation . Regulation IFNA10 TNF 9555981 499234 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the [interferon (IFN)-alpha] , IFN-beta , interleukin-6 (IL-6) , and *response* to NDV but not to Sendai virus . Regulation IFNA13 TLR7 18806803 1969822 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Regulation IFNA13 TLR7 19597505 2117988 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Regulation IFNA13 TLR7 24009514 2836827 In 2008 it was reported that plasmacytoid dendritic cells ( pDCs ) of SMs exhibit attenuated [interferon-alpha] ( IFN-a ) *responses* to ligands in vitro , and that species-specific amino acid substitutions in SM Interferon Regulatory Factor-7 (IRF7) are responsible for this observation . Regulation IFNA13 TNF 9555981 499235 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the [interferon (IFN)-alpha] , IFN-beta , interleukin-6 (IL-6) , and *response* to NDV but not to Sendai virus . Regulation IFNA14 TLR7 18806803 1969823 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Regulation IFNA14 TLR7 19597505 2117989 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Regulation IFNA14 TLR7 24009514 2836828 In 2008 it was reported that plasmacytoid dendritic cells ( pDCs ) of SMs exhibit attenuated [interferon-alpha] ( IFN-a ) *responses* to ligands in vitro , and that species-specific amino acid substitutions in SM Interferon Regulatory Factor-7 (IRF7) are responsible for this observation . Regulation IFNA14 TNF 9555981 499236 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the [interferon (IFN)-alpha] , IFN-beta , interleukin-6 (IL-6) , and *response* to NDV but not to Sendai virus . Regulation IFNA16 TLR7 18806803 1969824 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Regulation IFNA16 TLR7 19597505 2117990 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Regulation IFNA16 TLR7 24009514 2836829 In 2008 it was reported that plasmacytoid dendritic cells ( pDCs ) of SMs exhibit attenuated [interferon-alpha] ( IFN-a ) *responses* to ligands in vitro , and that species-specific amino acid substitutions in SM Interferon Regulatory Factor-7 (IRF7) are responsible for this observation . Regulation IFNA16 TNF 9555981 499237 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the [interferon (IFN)-alpha] , IFN-beta , interleukin-6 (IL-6) , and *response* to NDV but not to Sendai virus . Regulation IFNA17 TLR7 18806803 1969825 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Regulation IFNA17 TLR7 19597505 2117991 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Regulation IFNA17 TLR7 24009514 2836830 In 2008 it was reported that plasmacytoid dendritic cells ( pDCs ) of SMs exhibit attenuated [interferon-alpha] ( IFN-a ) *responses* to ligands in vitro , and that species-specific amino acid substitutions in SM Interferon Regulatory Factor-7 (IRF7) are responsible for this observation . Regulation IFNA17 TNF 9555981 499238 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the [interferon (IFN)-alpha] , IFN-beta , interleukin-6 (IL-6) , and *response* to NDV but not to Sendai virus . Regulation IFNA2 TLR7 18806803 1969826 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Regulation IFNA2 TLR7 19597505 2117992 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Regulation IFNA2 TLR7 24009514 2836831 In 2008 it was reported that plasmacytoid dendritic cells ( pDCs ) of SMs exhibit attenuated [interferon-alpha] ( IFN-a ) *responses* to ligands in vitro , and that species-specific amino acid substitutions in SM Interferon Regulatory Factor-7 (IRF7) are responsible for this observation . Regulation IFNA2 TNF 9555981 499239 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the [interferon (IFN)-alpha] , IFN-beta , interleukin-6 (IL-6) , and *response* to NDV but not to Sendai virus . Regulation IFNA21 TLR7 18806803 1969827 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Regulation IFNA21 TLR7 19597505 2117993 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Regulation IFNA21 TLR7 24009514 2836832 In 2008 it was reported that plasmacytoid dendritic cells ( pDCs ) of SMs exhibit attenuated [interferon-alpha] ( IFN-a ) *responses* to ligands in vitro , and that species-specific amino acid substitutions in SM Interferon Regulatory Factor-7 (IRF7) are responsible for this observation . Regulation IFNA21 TNF 9555981 499240 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the [interferon (IFN)-alpha] , IFN-beta , interleukin-6 (IL-6) , and *response* to NDV but not to Sendai virus . Regulation IFNA4 TLR7 18806803 1969828 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Regulation IFNA4 TLR7 19597505 2117994 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Regulation IFNA4 TLR7 24009514 2836833 In 2008 it was reported that plasmacytoid dendritic cells ( pDCs ) of SMs exhibit attenuated [interferon-alpha] ( IFN-a ) *responses* to ligands in vitro , and that species-specific amino acid substitutions in SM Interferon Regulatory Factor-7 (IRF7) are responsible for this observation . Regulation IFNA4 TNF 9555981 499241 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the [interferon (IFN)-alpha] , IFN-beta , interleukin-6 (IL-6) , and *response* to NDV but not to Sendai virus . Regulation IFNA5 TLR7 18806803 1969829 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Regulation IFNA5 TLR7 19597505 2117995 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Regulation IFNA5 TLR7 24009514 2836834 In 2008 it was reported that plasmacytoid dendritic cells ( pDCs ) of SMs exhibit attenuated [interferon-alpha] ( IFN-a ) *responses* to ligands in vitro , and that species-specific amino acid substitutions in SM Interferon Regulatory Factor-7 (IRF7) are responsible for this observation . Regulation IFNA5 TNF 9555981 499242 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the [interferon (IFN)-alpha] , IFN-beta , interleukin-6 (IL-6) , and *response* to NDV but not to Sendai virus . Regulation IFNA6 TLR7 18806803 1969830 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Regulation IFNA6 TLR7 19597505 2117996 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Regulation IFNA6 TLR7 24009514 2836835 In 2008 it was reported that plasmacytoid dendritic cells ( pDCs ) of SMs exhibit attenuated [interferon-alpha] ( IFN-a ) *responses* to ligands in vitro , and that species-specific amino acid substitutions in SM Interferon Regulatory Factor-7 (IRF7) are responsible for this observation . Regulation IFNA6 TNF 9555981 499243 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the [interferon (IFN)-alpha] , IFN-beta , interleukin-6 (IL-6) , and *response* to NDV but not to Sendai virus . Regulation IFNA7 TLR7 18806803 1969831 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Regulation IFNA7 TLR7 19597505 2117997 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Regulation IFNA7 TLR7 24009514 2836836 In 2008 it was reported that plasmacytoid dendritic cells ( pDCs ) of SMs exhibit attenuated [interferon-alpha] ( IFN-a ) *responses* to ligands in vitro , and that species-specific amino acid substitutions in SM Interferon Regulatory Factor-7 (IRF7) are responsible for this observation . Regulation IFNA7 TNF 9555981 499244 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the [interferon (IFN)-alpha] , IFN-beta , interleukin-6 (IL-6) , and *response* to NDV but not to Sendai virus . Regulation IFNA8 TLR7 18806803 1969832 Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less [interferon-alpha] in *response* to SIV and other and 9 ligands ex vivo . Regulation IFNA8 TLR7 19597505 2117998 pDCs derived from women produce markedly more [interferon-alpha (IFN-alpha)] in *response* to HIV-1 encoded ligands than pDCs derived from men , resulting in stronger secondary activation of CD8 ( + ) T cells . Regulation IFNA8 TLR7 24009514 2836837 In 2008 it was reported that plasmacytoid dendritic cells ( pDCs ) of SMs exhibit attenuated [interferon-alpha] ( IFN-a ) *responses* to ligands in vitro , and that species-specific amino acid substitutions in SM Interferon Regulatory Factor-7 (IRF7) are responsible for this observation . Regulation IFNA8 TNF 9555981 499245 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the [interferon (IFN)-alpha] , IFN-beta , interleukin-6 (IL-6) , and *response* to NDV but not to Sendai virus . Regulation IFNB1 CD14 10601848 655179 Important *role* of membrane associated in the induction of [IFN-beta] and subsequent nitric oxide production by murine macrophages in response to bacterial lipopolysaccharide . Regulation IFNB1 NEDD9 22427889 2573180 The differential *effects* of on [Ifnb] and Il12b expression inversely correlated with the function of one of its binding partners , c-Rel . Regulation IFNB1 PECAM1 18025177 1827650 In this study , we demonstrate that ligation with CD38-Fc fusion protein negatively *regulates* LPS induced proinflammatory cytokine TNF-alpha , IL-6 , and [IFN-beta] production by inhibiting JNK , NF-kappaB , and IFN regulatory factor 3 activation in macrophages . Regulation IFNB1 TLR7 17082622 1643291 *dependent* induction of [IFN-beta] mediates host defense against Trypanosoma cruzi . Regulation IFNB1 TLR7 17082622 1643311 These findings suggest that *dependent* expression of [IFN-beta] is involved in resistance to T. cruzi infection through the induction of IRG47 . Regulation IFNB1 TLR7 17897860 1811295 TLR3 and TLR7 are involved in expression of IL-23 subunits while TLR3 but not is *involved* in expression of [IFN-beta] by Theiler 's virus infected RAW264.7 cells . Regulation IFNB1 TLR7 18758466 1962312 Thus , mTOR signaling is crucial in mediated [IFN-alpha/beta] *responses* by pDCs . Regulation IFNB1 TLR7 19637227 2143088 Neonatal myeloid DC were shown to be deficient in [IFN-beta] and IL-12 synthesis in *response* to triggering . Regulation IFNB1 TLR7 20200270 2229553 In *response* to signaling , conventional DCs can also produce [IFN-beta] but not IFN-alpha in a type I IFN independent manner . Regulation IFNB1 TNF 12537690 1034149 An exaggerated production of has been reported in murine viral infections , in which mice become sensitized to low amounts of LPS and both interferon (IFN)-gamma and [IFN-alpha/beta] are *involved* in the macrophage induced release of TNF-alpha . Regulation IFNB1 TNF 1292634 207780 The latter findings support the idea that induction of HLA class I by TNF is not mediated solely by autocrine [IFN-beta] produced in *response* to . Regulation IFNB1 TNF 9555981 499246 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the interferon (IFN)-alpha , [IFN-beta] , interleukin-6 (IL-6) , and *response* to NDV but not to Sendai virus . Regulation IFNG ARSA 11238116 790478 In contrast , did not *affect* IL-13 , [interferon-gamma] , and IL-2 expression . Regulation IFNG EPHB2 16951314 1610457 Experiments with ERK-1/2 inhibitors demonstrated that bryostatin-1 induction of [IFN- gamma] and T-bet was *dependent* and IL-12 independent . Regulation IFNG EPHB2 9533450 496957 However , the production of IL-3 and IL-4 was only partially dependent upon ERK activation , whereas IL-5 , IL-10 , [IFN-gamma] and GM-CSF production was severely *affected* by diminished activation . Regulation IFNG EPHB2 9763606 537142 Integrin mediated signaling *regulates* [interferon gamma] production in human natural killer cells . Regulation IFNG IL1B 10653850 663319 We also show that T(h)1 cells but not T ( h ) 2 cells have increased expression of IL-18R and IL-1R , and produce [IFN-gamma] in *response* to IL-18 and/or . Regulation IFNG IL1B 11920321 926090 The *role* of endogenous interleukin (IL)-18 , IL-12 , , and tumor necrosis factor-alpha in the production of [interferon-gamma] induced by Candida albicans in human whole-blood cultures . Regulation IFNG IL1B 11920321 926091 Thus , C. albicans stimulates [IFN-gamma] production in an IL-18- , IL-12- , and *dependent* manner , whereas production of TNF and IL-8 is independent of these cytokines . Regulation IFNG IL1B 12789234 1097433 also increased VEGF production , but this was not *affected* by [IFN-gamma] ( P > .05 ) . Regulation IFNG IL1B 18239058 1877027 Human pancreatic periacinar myofibroblasts expressed IL-32alpha in *response* to , TNF-alpha , and [IFN-gamma] . Regulation IFNG IL1B 18550018 1923758 Feeding the ginsenoside diet resulted in lower ( P < 0.05 ) spleen IL-2 production , but the [IFN-gamma] , TNF-alpha and *response* to ConA was not different from control animals at 48 h . Regulation IFNG IL1B 18805021 1987119 A synergistic *role* for and TNFalpha in monocyte derived [IFNgamma] inducing activity . Regulation IFNG IL1B 20027291 2175572 Supernatants of Salmonella infected Mphi1 contained more IL-18 and IL-1beta as compared with supernatants of Mphi1 stimulated with isolated TLR agonists , and induced [IFN-gamma] production in human CD56 ( + ) cells in an IL-23 and *dependent* but IL-12 independent manner . Regulation IFNG IL1B 8360333 227771 In this study we have examined the *effect* of on [IFN-gamma] induced major histocompatibility complex ( MHC) class II (Ia ) in primary cultures of newborn murine astrocytes and microglial cells . Regulation IFNG IL1B 8439987 213284 Generally , arabinogalactan pretreatment induced an increased release of interferon gamma (IFN gamma) , tumor necrosis factor alpha , and IL-6 but only [IFN gamma] was *involved* in enhancement of NK cytotoxicity since cytotoxicity enhancement of PBMC and PNAC but not that of monocytes could be blocked when anti-IFN gamma antibodies were present during pretreatment . Regulation IFNG IL1B 8552275 337119 In this report , we examined [interferon-gamma (IFN-gamma)] and mediated *regulation* of the expression of C3 , the third component of complement , in a human astroglioma cell line . Regulation IFNG IL1B 9394800 468160 Comparison of the *effects* of interleukin-1 alpha , and interferon-gamma inducing factor on the production of [interferon-gamma] by natural killer . Regulation IFNG ITGAL 11882913 919662 Essential *role* of interaction in synergistic effect of IL-18 and IL-12 on [IFN-gamma] production in human PBMC . Regulation IFNG ITGB2 11882913 919677 These results as a whole indicated that synergistic effect of IL-18 and IL-12 on IFN-gamma production in human PBMC is ascribed to the synergism of the effect of two cytokines on ICAM-1 expression on monocytes and that the subsequent interaction *plays* an important role in the enhanced production of [IFN-gamma] . Regulation IFNG JAG1 11390498 822551 [IFN-gamma] secretion in *response* to H. pylori was correlated with gastritis , although splenocytes from all groups of mice secreted some IFN-gamma . Regulation IFNG JAG1 15067068 1231790 Moreover , the production of [IFN-gamma] in *response* to parasite was significantly increased in spleen cells from anti-CTLA-4 treated infected mice when compared with the production found in cells from IgG treated infected mice . Regulation IFNG JAG1 17475837 1738421 CD8+ T cells from rejector mice did not produce [IFN-gamma] in *response* to Ad5E1 tumor or use FasL to mediate intraocular tumor rejection . Regulation IFNG JAG1 9233629 445111 gamma delta T cells were found to rapidly expand and produce [IFN-gamma] in *response* to nonpeptide . Regulation IFNG JAG1 9233629 445117 In contrast , gamma delta T cells from the majority of HIV+ donors did not expand or express [IFN-gamma] in *response* to nonpeptide , even in the presence of IL-12 . Regulation IFNG JAG1 9574535 502519 Human gamma delta T cells have the ability to rapidly expand and produce [IFN-gamma] in *response* to nonpeptide of microbial pathogens , in particular a class of compounds known as the prenyl phosphates . Regulation IFNG KLF9 10605024 655629 The *role* of Sp family members , basic , and E box factors in the basal and [IFN-gamma] regulated expression of the human complement C4 promoter . Regulation IFNG SPHK1 11936187 894674 Apparently , activity is also *involved* in [IFN-gamma] induced calcium signals . Regulation IFNG SPHK1 18602364 1941488 In this study , to elucidate whether is *involved* in IL-18 induced [IFN-gamma] production , we measured IL-18 induced IFN-gamma production after pre-treatment with SPHK inhibitor (SKI) in NK-92MI cells . Regulation IFNG STAT4 10946290 722942 However , other signaling pathways can be used to bypass *dependent* production of [IFN-gamma] and enhance innate resistance to T. gondii . Regulation IFNG STAT4 11120802 758228 Since the precise *role* of in [IFN-gamma] induction has not been established , experiments were conducted to examine Stat4 activation of IFN-gamma and other genes required for cytokine induced expression of IFN-gamma . Regulation IFNG STAT4 11466347 839910 An absolute requirement for and a *role* for [IFN-gamma] as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex . Regulation IFNG STAT4 15307169 1284813 In summary , these results suggest that in contrast to IL-12 , IFN-alphaA does not play a functionally significant role in meditating the *dependent* induction of Th1 development or [IFN-gamma] production in CD4+ T cells . Regulation IFNG TCN1 16531121 1555240 We showed that adenovirus infection had no further effect on the phenotype , the ability to induce [IFN-gamma] producing *response* or the T cell stimulatory capacity of already mature DCs in vitro . Regulation IFNG TCN1 17785860 1790835 In contrast to IMP321 , TLR1-9 agonists induce IL-10 and are therefore unable to induce this [IFN-gamma+] *response* . Regulation IFNG TLR7 16670332 1558547 However , purified uNK cells did not respond directly to TLR agonists , but [IFN-gamma] was produced by uNK cells in *response* to stimulation when cocultured with APCs . Regulation IFNG TLR7 17289654 1698483 The tlr2 ( -/- ) or tlr7 ( -/- ) NK cells could not produce [IFN-gamma] in *response* to IL-12 plus TLR2 or ligands , respectively , indicating requirement of the corresponding TLRs . Regulation IFNG TLR7 17804388 1791119 Engagement of TLR3 , , and NKG2D *regulate* [IFN-gamma] secretion but not NKG2D mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12 . Regulation IFNG TLR7 17918201 1819410 In this study , we investigated which mouse B cell subsets are the most potent cytokine producers , and examined the *role* of in the control of secretion of IL-6 , IL-10 , IL-12 and [IFN-gamma] by B cells . Regulation IFNG TLR7 17918201 1819460 Thus , in *response* to combined stimulation , or via phorbol esters , [IFN-gamma] was secreted . Regulation IFNG TLR7 18782351 2012126 Thus , MyD88 dependent innate immune responses induced by L. pneumophila involve both *dependent* responses and IL-18R dependent production of [IFN-gamma] by natural killer cells , and these MyD88 dependent pathways can function independently to provide host protection against an intracellular pathogen . Regulation IFNG TLR7 19050265 1999335 We further show that this immunopathology is the result of *dependent* activation of [IFN-gamma] secretion by NK cells in response to the infection . Regulation IFNG TLR7 19710464 2133451 Moreover induced Vgamma9Vdelta2 [IFN-gamma] noncytolytic *response* led to efficient DC polarization into IL-12p70 producing cells . Regulation IFNG TLR7 21487893 2463693 To clarify the functional characteristics of cord blood ( CB ) NK cells , we examined the capacity of CB NK cells to produce [interferon gamma] ( IFN-? ) in *response* to the ligands . Regulation IFNG TNF 11678640 873677 PECAM-1 was also constitutively expressed on microvascular endothelial cells MvE and GEC , but at lower levels than on HUVEC , and expression by these cells also decreased in *response* to and [IFN-gamma] . Regulation IFNG TNF 11920321 926088 The *role* of endogenous interleukin (IL)-18 , IL-12 , IL-1beta , and in the production of [interferon-gamma] induced by Candida albicans in human whole-blood cultures . Regulation IFNG TNF 12085313 958980 To study the effect of preexisting T cell responses to DV on the severity of secondary virus infection , peripheral blood mononuclear cells ( PBMC ) from 10 subsequently hospitalized and 12 nonhospitalized Thai schoolchildren were stimulated with inactivated dengue antigens , and proliferation of [interferon (IFN)-gamma] or *responses* of the preinfection PBMC were measured . Regulation IFNG TNF 12537690 1034150 An exaggerated production of has been reported in murine viral infections , in which mice become sensitized to low amounts of LPS and both [interferon (IFN)-gamma] and IFN-alpha/beta are *involved* in the macrophage induced release of TNF-alpha . Regulation IFNG TNF 1334048 205824 These results suggest that both IL-1 and are the major cytokines affecting the EC functions that determine the association between the coagulation and the inflammatory response , and that [IFN-gamma] *affects* this phenomenon predominantly through the modification of the effects of these cytokines . Regulation IFNG TNF 1387149 196145 Scatchard analysis of binding data showed that neither nor IL-6 *affected* the affinity of [IFN-gamma] for its receptor . Regulation IFNG TNF 15123153 1242357 Our preliminary findings suggest that immunity against FIP is associated with TNF-alpha and IFN-gamma response imbalance , with high TNF-alpha/low IFN-gamma mRNA responses favouring disease and low [IFN-gamma] mRNA *responses* being indicative of immunity . Regulation IFNG TNF 16092457 1443468 This study examined whether the initial plasma levels of tumour necrosis factor alpha (TNFalpha) and [interferon gamma (IFNgamma)] in 131 children with newly diagnosed cancer were associated with haematopoietic suppression , and whether plasma levels of or haemoglobin at diagnosis *affects* long-term prognosis in childhood acute lymphoblastic leukaemia ( ALL ) . Regulation IFNG TNF 16410312 1513711 Here we show that a mouse lymph node ( LN ) -derived FRC cell line , BLS4 , expresses a transmembrane chemokine , CXC chemokine ligand (CXCL) 16 , in *response* to and [IFNgamma] . Regulation IFNG TNF 16580226 1550188 Treatment of monoclonal antibodies against cytokines showed that [IFN-gamma] and interleukin 10 (IL-10) were involved in maintenance of growth of S. Typhimurium mutant on day 10 after infection , and IFN-gamma , and transforming growth factor-beta ( TGF-beta ) were *involved* in maintenance of growth of this bacterium on day 30 after infection . Regulation IFNG TNF 1702807 151308 The additive *effect* of and IL-4 was more marked than that of TNF and [IFN-gamma] . Regulation IFNG TNF 17928893 1858633 Insights into gene modulation by therapeutic TNF and IFNgamma antibodies : *regulates* [IFNgamma] production by T cells and TNF regulated genes linked to psoriasis transcriptome . Regulation IFNG TNF 17928893 1858634 Furthermore , these data establish an unexpected *effect* of blockade on [IFNgamma] synthesis by T cells . Regulation IFNG TNF 1829652 161355 Whilst had no significant *effect* on [IFN-gamma] release by NK cells , a 6-hr exposure to IL-2 or PMA stimulated an increase in the amount secreted per single cell . Regulation IFNG TNF 1846894 153369 These studies showed that the number of receptors increased on macrophages vs maturation in culture and was negatively *controlled* by [IFN-gamma] . Regulation IFNG TNF 18805021 1987118 A synergistic *role* for IL-1beta and in monocyte derived [IFNgamma] inducing activity . Regulation IFNG TNF 1899098 152041 In the present studies , the *effect* of on [IFN-gamma] induced MHC class II expression was tested in various cell lines . Regulation IFNG TNF 1899098 152042 However , when differentiation was induced in these cells by TPA or IFN-gamma , the additive *effect* of on the [IFN-gamma] induced DR expression was eliminated . Regulation IFNG TNF 19291774 2086833 Both [IFNgamma] and TNFalpha are important in this injury process , but *acts* as an autocrine amplifier of Kupffer cell function , rather than as a direct effector of hepatocellular damage . Regulation IFNG TNF 19375139 2074701 A positive correlation was observed between the growth indices ( GI ) of H37Rv , Beijing and CAS1 strains and the *responses* they induced [ Pearson 's correlation coefficient ( R ( 2 ) ) : 0.936 , 0.775 and 0.55 , respectively ] , and also between GI and [IFN-gamma] production ( R ( 2 ) : 0.422 , 0.946 , 0.674 ) . Regulation IFNG TNF 2120581 141926 Therefore , we investigated the *effect* of interferon-alpha (IFN-alpha) , IFN-gamma and ( TNF-alpha ) on the induction of LAK activity by IL-2 , and the induction of [IFN-gamma] and TNF-alpha by IL-2 . Regulation IFNG TNF 22526394 2595905 The human colon cell line , HT-29 , increased interleukin (IL)-8 expression in *response* to recombinant human , but not in response to bacterial ligands and [interferon (IFN)-gamma] . Regulation IFNG TNF 2502555 115173 Influence of on the modulation by interferon-gamma of HLA class II molecules in human thyroid cells and its *effect* on [interferon-gamma] binding . Regulation IFNG TNF 8049441 267470 Likewise , maximal uPA binding capacity was increased 2.8-fold by [IFN gamma] ( P < .02 ) , but was not *affected* by . Regulation IFNG TNF 8097322 217619 In contrast , IL-10 inhibits hk-LM induced IFN-gamma production at two levels : ( i ) by inhibiting TNF and IL-12 production from these cultures ( presumably from the macrophage ) and ( ii ) by inhibiting the stimulatory *effects* of IL-12 and on NK-cell [IFN-gamma] production . Regulation IFNG TNF 8366291 229322 Cyclosporin A inhibits nitric oxide production by L929 cells in *response* to and [interferon-gamma] . Regulation IFNG TNF 8575836 340879 The question was asked whether is *involved* in regulation of [interferon gamma (IFN gamma)] production by T cells . Regulation IFNG TNF 8632057 357228 Basal expression of ICAM-1 molecules was enhanced by and to a lesser extent by IFN-beta , but was not *affected* by [IFN-gamma] . Regulation IFNG TNF 8843212 387370 Earlier and stronger interleukin (IL)-12 , [interferon-gamma (IFN)-gamma] , and *responses* were found in Borrelia burgdorferi infected , vitamin A-deficient mice compared with controls . Regulation IFNG TNF 9927530 588646 We investigated the *role* of in the regulation of MHC class II antigens and cytokine mRNA expression of TNF , [interferon-gamma (IFN)] , IL-2 , IL-4 , and IL-10 in cardiac allografts to elucidate its immunological mechanism . Regulation IGF1 ALDH2 20731752 2452708 Our data further depicted a likely *role* of Caspase-3 , and AMPK activation in [IGF-1] deficiency induced ` desensitization ' of alcoholic cardiomyopathy . Regulation IGF1 ARSG 22194889 2518656 Here we examined the *effects* of on [IGF-1] and glucose metabolism in ß-cells exposed to oxidative stress . Regulation IGF1 CTGF 18586434 1935264 *Involvement* of in [insulin-like growth factor-I (IGF1)] stimulation of proliferation of a bovine mammary epithelial cell line . Regulation IGF1 CTGF 18586434 1935270 Despite being an IGF binding protein , CTGF did not affect IGF1 induced phosphorylation of IGF1 receptor (IGF1R) or IGF1R expression in MAC-T cells , indicating that the attenuating *effect* of on [IGF1] stimulated proliferation of MAC-T cells was not mediated by decreasing IGF1 's ability to bind to IGF1R or by decreasing IGF1R expression . Regulation IGF1 CTGF 18586434 1935272 Overall , these results suggest a novel biochemical and functional relationship between CTGF and IGF1 in the bovine mammary gland , where IGF1 may inhibit CTGF expression to reduce the attenuating *effect* of on [IGF1] stimulated proliferation of epithelial cells . Regulation IGF1 EPHB2 11228049 763998 PD98059 inhibited activation of and LY294002 repressed activation of Akt in response to IGF-I , but did not *affect* tyrosine phosphorylation of the [IGF-IR] , IRS-1 , IRS-2 , or Shc . Regulation IGF1 EPHB2 19834495 2216954 We also report that [IGF-I] protects myoblasts from H ( 2 ) O ( 2 ) -induced apoptosis through a mechanism that requires p110 alpha , but may be *independent* of Akt or under conditions of Akt and ERK inhibition . Regulation IGF1 FOXO1 11735247 885714 In the present study the potential *regulation* of the [IGF-I receptor (IGF-I-R)] gene by at the transcriptional level was investigated . Regulation IGF1 FOXO1 15319368 1303748 [IGF-I] *regulates* survival at the nuclear level through accumulation of phospho-Akt in DRG neuronal nuclei , increased CREB mediated transcription , and nuclear exclusion of . Regulation IGF1 FOXO1 24406377 2926923 The neurodegenerative effects of selenium are inhibited by and PINK1/PTEN *regulation* of [insulin/insulin-like growth factor] signaling in Caenorhabditis elegans . Regulation IGF1 IGFBP1 10527130 654230 Studies indicate that expression and production in the developing follicle is dependent on both cell type and follicle size and is *regulated* by [IGF-1] and gonadotropins . Regulation IGF1 IGFBP1 11716549 881770 We compared the growth rates , production , IGF I binding characteristics , IGF 1R protein and mRNA levels , and the acute [IGF I] *response* ( stimulation of glycogen synthesis ) after pretreatment of the cells in serum-free medium with or without added IGF I or medium supplemented with 5 % fetal calf serum ( FCS ) . Regulation IGF1 IGFBP1 1695626 137128 These studies utilized IGF-I analogs that have reduced binding affinity for either the type 1 IGF receptor or binding proteins to study the ligand specificity of and the *role* of IGF-BP-1 in modulating the biological activity of [IGF-I] . Regulation IGF1 IGFBP1 1721071 171722 The inhibitory *effect* of on [IGF-1] mediated 3H-thymidine incorporation into DNA was dose dependent . Regulation IGF1 IGFBP1 2469478 109477 This biological activity of recombinant truncated [IGF-1] was not *affected* by the at concentrations which abolished the biological activity of recombinant IGF-1 . Regulation IGF1 IGFBP1 7511786 241693 Culture with 10 ( -9 ) M insulin lowered gene transcription 50 % below control levels ( 10-11 M ) but did not *affect* [IGF-I] gene transcription ; Regulation IGF1 IGFBP1 7512318 250296 These results suggested that *regulates* [IGF-I] activity in pregnancy in a similar manner to that in the non-pregnant state . Regulation IGF1 IGFBP1 8626837 361049 The genetic influences on [IGF-I] levels were *independent* of the genetic influences on insulin and levels . Regulation IGF1 IGFBP1 8902230 393773 The results indicate that production in the developing ovine ovarian follicle is dependent on both cell type and follicle size and is *regulated* by [IGF-I] and gonadotropins . Regulation IGF1 IGFBP1 8949570 400654 An inverse correlation between free IGF-I and IGFBP-1 supports the hypothesis that *plays* an important role in the acute modulation of free [IGF-I] levels . Regulation IGF1 IL1B 1425428 202276 To determine whether increased or decreased IGF-I production in bone might mediate some of the effects of IL-1 on bone turnover , the *effects* of IL-1 alpha and on [IGF-I] release from neonatal mouse calvaria in organ culture were examined . Regulation IGF1 IL1B 16897751 1607883 Northern blot analysis suggested *regulation* of [IGF-I] and , to some extent , IGF-IR was mediated by transcription ; Regulation IGF1 IL1B 17518712 1762068 Alginate encapsulation impacts the [insulin-like growth factor-I] system of monolayer expanded equine articular chondrocytes and cell *response* to . Regulation IGF1 IL1B 7510466 249919 *Effects* of on [insulin-like growth factor-I] autocrine/paracrine axis in cultured rat articular chondrocytes . Regulation IGF1 IL1B 7510466 249920 To clarify the interaction of tissue destruction and repair of articular cartilage during inflammation , the *effects* of on the expression of [insulin-like growth factor I (IGF-I)] , its receptor , and its binding proteins were examined . Regulation IGF1 IL1B 8828463 385390 We examined the *effects* of IL-1 alpha and on insulin and [insulin-like growth factor I (IGF-I)] stimulation of cell growth and found that both IL-1s inhibited anchorage dependent and independent growth of MCF-7 breast cancer cells . Regulation IGF1 IL1B 9025720 405830 As many of the acute inflammatory responses in critical illness are mediated by the proinflammatory cytokines interleukin 1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha) , the present studies evaluated and TNF-alpha *effects* on steady-state and GH-stimulated [IGF-I] synthesis and GH receptor mRNA levels . Regulation IGF1 IL1B 9025720 405832 In cells not stimulated with GH , modest inhibitory *effects* of on GH receptor mRNA , IGF-I mRNA and [IGF-I] protein levels were seen . Regulation IGF1 PLAU 10509812 650985 These data suggest that in human breast fibroblasts [IGF-1] *controls* the expression of and that , possibly due to an altered sensitivity to uPA , tumor associated fibroblasts have escaped this local control mechanism . Regulation IGF1 PLAU 11245436 793089 In this study , we investigated the signal transduction pathway through which [IGF-I] *regulates* . Regulation IGF1 SMN2 22669976 2632898 *dependent* induction of CCL2 and [IGF1] mRNAs resulted in increased intracellular levels and secretion of the respective protein products . Regulation IGF1 TNF 10664866 578420 The authors focus on some of the molecular events involved in and IFN-gamma signal transduction and the *regulation* of iNOS and [IGF-I] genes in macrophages . Regulation IGF1 TNF 11369437 817404 This effect was associated with significant reductions in the levels of IGF-l-R mRNA and protein , and with inhibition of IGF-l-R promoter activity , suggesting that and IFN-gamma *affect* [IGF-l-R] gene expression at the transcriptional level . Regulation IGF1 TNF 11889017 920118 *regulates* [insulin-like growth factor-1] and insulin-like growth factor binding protein-3 expression in vascular smooth muscle . Regulation IGF1 TNF 12169440 973779 To investigate potential mechanisms , the *effects* of on the [IGF-I] response to GH and GH signaling were examined in cultured rat hepatocytes ( CWSV-1 ) . Regulation IGF1 TNF 12584730 1058771 *regulation* of [insulin-like growth factor-I] , type 1 IGF receptor , and IGF binding protein expression in cerebellum of transgenic mice . Regulation IGF1 TNF 12697682 1081353 Yet inhibitor studies indicate that nitric oxide did not mediate the *effect* of on [IGF-I] mRNA expression . Regulation IGF1 TNF 16728464 1612357 Human progenitor cells from bone marrow or adipose tissue produce VEGF , HGF , and [IGF-I] in *response* to by a p38 MAPK dependent mechanism . Regulation IGF1 TNF 18719026 1984927 IkappaBalphaS/A and IkappaBalphaTrunc ameliorated the inhibitory *effects* of on GH-inducible Spi 2.1 and [IGF-I] promoter activity . Regulation IGF1 TNF 18719026 1984928 Cycloheximide did not antagonize the inhibitory *effects* of on GH-inducible [IGF-I] expression . Regulation IGF1 TNF 22492039 2583491 Furthermore , astrocytes in culture express high levels of FGF-2 in response to IL-1ß , and [IGF-1] in *response* to stimulation . Regulation IGF1 TNF 23079385 2695010 The secretion of [IGF-I] is *affected* by GH , IL-1ß and , whereas IGF-II is affected by TNF-a only . Regulation IGF1 TNF 23677929 2801131 Finally , our data suggest that the IRA isoform and its association with TNF-R1 or [IGF-IR] confers proliferative advantage to VSMCs , mainly in *response* to or IGF-II , which might be of significance in the early atherosclerotic process . Regulation IGF1 TNF 7503312 333209 *Regulation* of [insulin-like growth factor-I (IGF-I)] and IGF binding proteins by . Regulation IGF1 TNF 7522842 272139 In the present study we have investigated the *effect* of on the secretion of [insulin-like growth factor I (IGF-I)] and IGF binding protein 4 (IGFBP-4) by clonal mouse osteoblasts ( MC3T3-E1 cells ) using subconfluent in vitro cultures and serum-free conditions . Regulation IGF1 TNF 9025720 405829 As many of the acute inflammatory responses in critical illness are mediated by the proinflammatory cytokines interleukin 1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha) , the present studies evaluated IL-1 beta and *effects* on steady-state and GH-stimulated [IGF-I] synthesis and GH receptor mRNA levels . Regulation IGF1 TNF 9048612 416819 To determine whether cytokines can directly inhibit the production of IGF-I by the liver , we investigated the *regulation* of [IGF-I] gene expression by interleukin (IL)-1 beta , IL-6 , and ( 10 ng/ml ) in a model of rat primary cultured hepatocytes . Regulation IGF1 TNF 9397943 291198 Finally , the *effect* of on [IGF-I] gene expression was investigated since IGF-I enhances Leydig cell androgen formation and IGF-I gene is expressed in high levels in Leydig cells . Regulation IGF1R FOXO1 20663909 2305265 We also provide the first direct evidence that FGFR4 and [IGF1R] are the *targets* for . Regulation IGF1R IL6R 14592826 1209478 The synergistic *effects* of highly expressed on [IGF-I receptor] mediated signals provide a novel insight into the Jak independent IL-6 signaling mechanism of receptor cross-talk in human myeloma cells . Regulation IGF1R IL6R 17142955 1653787 The synergistic *effects* of on [IGF-I receptor] mediated signals provide a novel insight into a Jak independent IL-6 signaling mechanism of receptor cross talk in human myeloma cells . Regulation IGF2 EPHB2 11228049 763999 PD98059 inhibited activation of and LY294002 repressed activation of Akt in response to IGF-I , but did not *affect* tyrosine phosphorylation of the [IGF-IR] , IRS-1 , IRS-2 , or Shc . Regulation IGF2 TNF 11369437 817406 This effect was associated with significant reductions in the levels of IGF-l-R mRNA and protein , and with inhibition of IGF-l-R promoter activity , suggesting that and IFN-gamma *affect* [IGF-l-R] gene expression at the transcriptional level . Regulation IGF2 TNF 12584730 1058772 *regulation* of insulin-like growth factor-I , type 1 [IGF] receptor , and IGF binding protein expression in cerebellum of transgenic mice . Regulation IGF2 TNF 23079385 2695012 The secretion of IGF-I is affected by GH , IL-1ß and TNF-a , whereas [IGF-II] is *affected* by only . Regulation IGF2 TNF 23677929 2801133 Finally , our data suggest that the IRA isoform and its association with TNF-R1 or [IGF-IR] confers proliferative advantage to VSMCs , mainly in *response* to or IGF-II , which might be of significance in the early atherosclerotic process . Regulation IGFBP1 ARG1 9733769 531023 Biosensor interaction analysis binding studies demonstrate the *involvement* of and Arg50 in [IGFBP-1] binding , while experiments with the IGF-I receptor implicate Arg21 , Arg36-Arg37 , and Arg56 as part of the receptor binding epitope . Regulation IGFBP1 ARG2 9733769 531024 Biosensor interaction analysis binding studies demonstrate the *involvement* of and Arg50 in [IGFBP-1] binding , while experiments with the IGF-I receptor implicate Arg21 , Arg36-Arg37 , and Arg56 as part of the receptor binding epitope . Regulation IGFBP1 AZU1 21550830 2440698 The *effect* of on [IGFBP-] and IGF-activity needs to be further investigated . Regulation IGFBP1 BMP7 7532581 292102 The *effect* of on [IGFBP] production was time and dose dependent . Regulation IGFBP1 CRK 17109117 1732107 However this induction ratio was smaller than that of rubratoxin B-induced secretion , suggesting that *regulate* [IGFBP-1] secretion both transcriptionally and post-transcriptionally . Regulation IGFBP1 DES 8536631 346131 Ligand blotting indicated changes in mammary gland secretion of [IGFBP] in *response* to expression . Regulation IGFBP1 EGF 1380055 193138 These results suggest that *regulates* [IGFBP-1] secretion in human granulosa-luteal cells . Regulation IGFBP1 EGF 7686479 222145 The [IGFBP-1] *response* to was most dramatic in the first few days of life . Regulation IGFBP1 EGF 9401175 469491 The *effects* of IGF-I and on [IGFBP] secretion diminished with increasing cell differentiation . Regulation IGFBP1 FGF2 10737893 679619 Neither growth hormone (GH) , , nor thyroxine ( T ( 4 ) ) had any *effect* on [IGFBP] expression or release . Regulation IGFBP1 FGF2 8754786 374432 The stimulatory *effect* of and IGF-I on [IGFBP] production was apparent after a 2- to 3-day exposure of the mesencephalic cultures to the peptides . Regulation IGFBP1 FOXM1 7524494 272379 binding at this site may *play* an important role in the multihormonal regulation of hepatic [IGFBP-1] gene expression . Regulation IGFBP1 FOXO1 12163409 972367 In HepG2 cells , Hoxa5 has little effect by itself but inhibits the *dependent* activation of the [IGFBP1] promoter . Regulation IGFBP1 FOXO1 15200677 1267935 Subsequent studies in vitro established that [IGFBP-1] is transcriptionally *regulated* by and HOXA10 which together upregulate the IGFBP-1 promoter activity . Regulation IGFBP1 GCG 1706258 153018 To study the *role* of GH and in the regulation of IGF-I and [IGF-BP] production , we examined IGF-I and IGF-BPs secreted by primary rat hepatocytes cultured in a serum-free medium . Regulation IGFBP1 GCG 7521339 243688 Thereafter , blood samples for determination of serum glucose , insulin , insulin-like growth factor binding protein-1 ( IGFBP-1 ) , GH , and insulin-like growth factor-I (IGF-I) concentrations were collected for 180 min . [IGFBP-1] concentrations increased significantly in *response* to , with maximal values observed at 90 min [ in healthy subjects from 36 +/- 6 to 58 +/- 10 micrograms/L ( P < 0.05 ) , in GH-deficient patients from 36 +/- 4 to 54 +/- 6 micrograms/L ( P < 0.001 ) , and in IDDM patients from 115 +/- 18 to 167 +/- 27 micrograms/L ( P < 0.05 ) ] . Regulation IGFBP1 GH1 10207508 606834 Evidence supporting a direct suppressive *effect* of on serum [IGFBP-1] levels . Regulation IGFBP1 GH1 10737893 679620 Neither , fibroblast growth factor-2 , nor thyroxine ( T ( 4 ) ) had any *effect* on [IGFBP] expression or release . Regulation IGFBP1 GH1 1379198 192798 This dependent *regulation* of IGF-I and [IGFBP-1] production by adult rat hepatocytes in culture indicates an important autocrine/paracrine role for IGF-I , particularly during liver regeneration after extensive organ mass loss . Regulation IGFBP1 GH1 1710624 158201 Short and long term *effects* of on circulating levels of insulin-like growth factor-I (IGF-I) , [IGF binding protein-1] , and insulin : a placebo controlled study . Regulation IGFBP1 GH1 7564093 324356 The *effects* of and fasting on renal insulin-like growth factor-I (IGF-I) and [IGF binding proteins (IGFBP)-1] , -2 , -3 , -4 , -5 were examined in spontaneous dwarf rats ( SDR ) which have a complete and specific lack of GH among pituitary hormones . Regulation IGFBP1 GHRH 9557822 499965 The aim of the present study was to evaluate , in pre-menopausal and post-menopausal women with body mass index ( BMI ) > or = or < 25 , the basal plasma levels of growth hormone (GH) , insulin-like growth factor (IGF)-I and -II , [IGF binding protein (IGFBP)-1] and -3 , and the *response* of GH and IGFBP-1 and -3 to and GHRH plus arginine tests . Regulation IGFBP1 HCG11 10655460 663666 To examine the synergistic *effect* of with MPA and oestradiol on SOD and [IGFBP-1] expression , ESC were incubated with HCG in the presence or absence of MPA and oestradiol . Regulation IGFBP1 HCG11 10655460 663802 had no synergistic *effect* on SOD and [IGFBP-1] expression . Regulation IGFBP1 HCG14 10655460 663667 To examine the synergistic *effect* of with MPA and oestradiol on SOD and [IGFBP-1] expression , ESC were incubated with HCG in the presence or absence of MPA and oestradiol . Regulation IGFBP1 HCG14 10655460 663803 had no synergistic *effect* on SOD and [IGFBP-1] expression . Regulation IGFBP1 HCG15 10655460 663668 To examine the synergistic *effect* of with MPA and oestradiol on SOD and [IGFBP-1] expression , ESC were incubated with HCG in the presence or absence of MPA and oestradiol . Regulation IGFBP1 HCG15 10655460 663804 had no synergistic *effect* on SOD and [IGFBP-1] expression . Regulation IGFBP1 HCG16 10655460 663671 To examine the synergistic *effect* of with MPA and oestradiol on SOD and [IGFBP-1] expression , ESC were incubated with HCG in the presence or absence of MPA and oestradiol . Regulation IGFBP1 HCG16 10655460 663807 had no synergistic *effect* on SOD and [IGFBP-1] expression . Regulation IGFBP1 HCG17 10655460 663682 To examine the synergistic *effect* of with MPA and oestradiol on SOD and [IGFBP-1] expression , ESC were incubated with HCG in the presence or absence of MPA and oestradiol . Regulation IGFBP1 HCG17 10655460 663818 had no synergistic *effect* on SOD and [IGFBP-1] expression . Regulation IGFBP1 HCG18 10655460 663681 To examine the synergistic *effect* of with MPA and oestradiol on SOD and [IGFBP-1] expression , ESC were incubated with HCG in the presence or absence of MPA and oestradiol . Regulation IGFBP1 HCG18 10655460 663817 had no synergistic *effect* on SOD and [IGFBP-1] expression . Regulation IGFBP1 HCG20 10655460 663679 To examine the synergistic *effect* of with MPA and oestradiol on SOD and [IGFBP-1] expression , ESC were incubated with HCG in the presence or absence of MPA and oestradiol . Regulation IGFBP1 HCG20 10655460 663815 had no synergistic *effect* on SOD and [IGFBP-1] expression . Regulation IGFBP1 HCG21 10655460 663680 To examine the synergistic *effect* of with MPA and oestradiol on SOD and [IGFBP-1] expression , ESC were incubated with HCG in the presence or absence of MPA and oestradiol . Regulation IGFBP1 HCG21 10655460 663816 had no synergistic *effect* on SOD and [IGFBP-1] expression . Regulation IGFBP1 HCG22 10655460 663677 To examine the synergistic *effect* of with MPA and oestradiol on SOD and [IGFBP-1] expression , ESC were incubated with HCG in the presence or absence of MPA and oestradiol . Regulation IGFBP1 HCG22 10655460 663813 had no synergistic *effect* on SOD and [IGFBP-1] expression . Regulation IGFBP1 HCG23 10655460 663669 To examine the synergistic *effect* of with MPA and oestradiol on SOD and [IGFBP-1] expression , ESC were incubated with HCG in the presence or absence of MPA and oestradiol . Regulation IGFBP1 HCG23 10655460 663805 had no synergistic *effect* on SOD and [IGFBP-1] expression . Regulation IGFBP1 HCG24 10655460 663675 To examine the synergistic *effect* of with MPA and oestradiol on SOD and [IGFBP-1] expression , ESC were incubated with HCG in the presence or absence of MPA and oestradiol . Regulation IGFBP1 HCG24 10655460 663811 had no synergistic *effect* on SOD and [IGFBP-1] expression . Regulation IGFBP1 HCG25 10655460 663670 To examine the synergistic *effect* of with MPA and oestradiol on SOD and [IGFBP-1] expression , ESC were incubated with HCG in the presence or absence of MPA and oestradiol . Regulation IGFBP1 HCG25 10655460 663806 had no synergistic *effect* on SOD and [IGFBP-1] expression . Regulation IGFBP1 HCG26 10655460 663678 To examine the synergistic *effect* of with MPA and oestradiol on SOD and [IGFBP-1] expression , ESC were incubated with HCG in the presence or absence of MPA and oestradiol . Regulation IGFBP1 HCG26 10655460 663814 had no synergistic *effect* on SOD and [IGFBP-1] expression . Regulation IGFBP1 HCG27 10655460 663676 To examine the synergistic *effect* of with MPA and oestradiol on SOD and [IGFBP-1] expression , ESC were incubated with HCG in the presence or absence of MPA and oestradiol . Regulation IGFBP1 HCG27 10655460 663812 had no synergistic *effect* on SOD and [IGFBP-1] expression . Regulation IGFBP1 HCG4 10655460 663672 To examine the synergistic *effect* of with MPA and oestradiol on SOD and [IGFBP-1] expression , ESC were incubated with HCG in the presence or absence of MPA and oestradiol . Regulation IGFBP1 HCG4 10655460 663808 had no synergistic *effect* on SOD and [IGFBP-1] expression . Regulation IGFBP1 HCG8 10655460 663673 To examine the synergistic *effect* of with MPA and oestradiol on SOD and [IGFBP-1] expression , ESC were incubated with HCG in the presence or absence of MPA and oestradiol . Regulation IGFBP1 HCG8 10655460 663809 had no synergistic *effect* on SOD and [IGFBP-1] expression . Regulation IGFBP1 HCG9 10655460 663674 To examine the synergistic *effect* of with MPA and oestradiol on SOD and [IGFBP-1] expression , ESC were incubated with HCG in the presence or absence of MPA and oestradiol . Regulation IGFBP1 HCG9 10655460 663810 had no synergistic *effect* on SOD and [IGFBP-1] expression . Regulation IGFBP1 HOXA10 15200677 1267936 Subsequent studies in vitro established that [IGFBP-1] is transcriptionally *regulated* by FOXO1 and which together upregulate the IGFBP-1 promoter activity . Regulation IGFBP1 HOXA10 17350963 1727206 The functional *role* of in [IGFBP1] expression was further explored using human endometrial stromal cells (HSC) . Regulation IGFBP1 IARS 11445561 850484 Forkhead ( FKHR ) recognizes IRS sequences , is phosphorylated in response to insulin , and mediates insulin inhibition of basal [IGFBP-1] transcription in an *dependent* manner . Regulation IGFBP1 IFNG 9435438 482539 We studied the *effects* of and activin A , which decrease progesterone accumulation , on granulosa cell [IGFBP] production and apoptosis . Regulation IGFBP1 IGF1 10226803 610425 In the present study , we therefore characterized the IGFBPs secreted by bovine adrenocortical cells in primary culture , and investigated the *effect* of corticotropin ( ACTH ) and recombinant human and IGF-II on the regulation of [IGFBP] synthesis . Regulation IGFBP1 IGF1 10226803 610443 In contrast to their different steroidogenic potency , no significant difference in the stimulatory *effect* of and IGF-II on [IGFBP] secretion was found . Regulation IGFBP1 IGF1 10326624 612835 [IGF BP-1] release was not *affected* by insulin and in the presence of both sera . Regulation IGFBP1 IGF1 10527130 654237 Studies indicate that [IGFBP] expression and production in the developing follicle is dependent on both cell type and follicle size and is *regulated* by and gonadotropins . Regulation IGFBP1 IGF1 10801263 691493 *Regulation* of [IGFBP] production by is mediated by activation of distinct MAP kinase and PI 3-kinase pathways , the same pathways through which IGF-I stimulates growth . Regulation IGFBP1 IGF1 11241178 791945 In the present study , we identified and characterized IGFBP synthesis in normal adult human adrenocortical cells in primary culture , and investigated the *effect* of ACTH and recombinant human and -II on the regulation of [IGFBP] expression and secretion . Regulation IGFBP1 IGF1 11474316 841765 Therefore , we investigated the expression of IGFBPs , collagen and collagenase activity in rat colitis and the *effects* of on [IGFBP] and collagen expression in rat colonic smooth muscle cells . Regulation IGFBP1 IGF1 11716549 881778 We compared the growth rates , [IGFBP] production , IGF I binding characteristics , IGF 1R protein and mRNA levels , and the acute *response* ( stimulation of glycogen synthesis ) after pretreatment of the cells in serum-free medium with or without added IGF I or medium supplemented with 5 % fetal calf serum ( FCS ) . Regulation IGFBP1 IGF1 1281161 205625 These results demonstrate coordinate *regulation* of [IGFBP] by serum starvation and , such that at low concentrations of IGF-I , cell surface binding protein increases whereas binding protein secretion decreases . Regulation IGFBP1 IGF1 12933666 1132615 Complementary studies demonstrated that [IGFBP-1] also decreased the rates of protein synthesis under basal conditions and in *response* to stimulation by when added in vitro to the fast-twitch epitrochlearis muscle . Regulation IGFBP1 IGF1 1381377 196068 Inhibition of [IGFBP-1] production in *response* to was dose dependent , with the highest effect observed at 5 nM IGF-I . Regulation IGFBP1 IGF1 1381377 196070 A significant correlation was found between the increase in E2 and inhibition of [IGFBP-1] secretion in *response* to . Regulation IGFBP1 IGF1 15845624 1418609 We therefore studied the *effect* of on [IGFBP] synthesis and the involved intracellular signaling pathways in two cell culture models of rat growth plate chondrocytes . Regulation IGFBP1 IGF1 1697605 139556 Cultured human decidual cells release three IGF-BPs with 24,000 , 30,000 , and 34,000 Mr. Using ligand blot analysis and an RIA for the 30,000-Mr form ( IGF-BP-1 ) , we examined the *effects* of ( 10-1,000 ng/ml ) , insulin ( 10-10,000 ng/ml ) , and relaxin ( 10-250 ng/ml ) on decidual cell [IGF-BP] release after 120 h of hormone exposure . Regulation IGFBP1 IGF1 1717510 166802 The IGF-I induced change in IGFBP levels was not a type I receptor mediated *effect* on [IGFBP] synthesis because ( a ) high concentrations of insulin did not mimic IGF-I 's effect ; Regulation IGFBP1 IGF1 7505463 237629 We have investigated the *regulation* by insulin , , and IGF-II , of [IGFBP] secretion in human endometrial stromal cells decidualized in vitro , and examined the interrelationship between the induced changes in IGFBP levels and the biological responses of stromal cells to IGFs . Regulation IGFBP1 IGF1 7505463 237651 The *effects* of and IGF-II on [IGFBP-1] secretion were biphasic , with initial stimulation ( 200-250 % ) that peaked at 1 and 10 ng/ml , respectively , followed by inhibition at higher concentrations ( half maximal inhibition at 3 ng/ml and 30 ng/ml , respectively ) . Regulation IGFBP1 IGF1 7505463 237656 These data indicate that endometrial stromal cell IGFBP-1 is regulated by insulin , at concentrations that are compatible with insulin acting via its own receptor , while the *effects* of and IGF-II on [IGFBP-1] secretion , are suggestive of their acting probably through the type I IGF receptor . Regulation IGFBP1 IGF1 7505466 237667 When considered with previous data regarding expression of IGFBP-1 and the type I IGF receptor , our results suggest that *regulation* of [IGFBP-1] may play an as yet undefined role in fetal development and postnatal hepatic regeneration . Regulation IGFBP1 IGF1 7525256 276890 The presence of a larger isoform of IGFBP-2 in a differentiation dependent manner and a potentially novel [IGFBP] in *response* to suggests that these IGFBPs may be important in modulating IGF-I action in adipogenesis . Regulation IGFBP1 IGF1 7534698 297009 These data demonstrate that IGF peptide and glucocorticoid individually modulate IGFBP expression and indicate that glucocorticoid has distinct effects on *regulation* of [IGFBP] depending upon the particular IGFBP and the underlying mechanism of IGF regulation . Regulation IGFBP1 IGF1 7684393 217571 These data indicate that [IGFBP-1] and E2 are differentially *regulated* by in the human ovary . Regulation IGFBP1 IGF1 8636256 362244 Preincubation with antiinsulin receptor antibody IR-47-9 alleviated inhibitory *effect* of insulin , but not of on [IGFBP-1] production . Regulation IGFBP1 IGF1 8691111 372686 Since may *regulate* [IGFBP] production , the effect of IGF-I on IGFBPs expressed by TC-1 cells was determined . Regulation IGFBP1 IGF1 8754786 374433 The stimulatory *effect* of bFGF and on [IGFBP] production was apparent after a 2- to 3-day exposure of the mesencephalic cultures to the peptides . Regulation IGFBP1 IGF1 8902230 393780 The results indicate that [IGFBP] production in the developing ovine ovarian follicle is dependent on both cell type and follicle size and is *regulated* by and gonadotropins . Regulation IGFBP1 IGF1 8958789 401721 In summary , after CLP there was a reduction in both circulating and hepatic mRNA levels associated with a specific and differential *regulation* of hepatic [IGFBP-1] , -2 and -3 mRNA levels . Regulation IGFBP1 IGF1 9401175 469492 The *effects* of and EGF on [IGFBP] secretion diminished with increasing cell differentiation . Regulation IGFBP1 IGF1 9439529 475008 In fact , ( 1 ) IGFBP mRNA levels were not modified after stimulation with 100 nmol/L IGF-I , ( 2 ) 100 nmol/L plus an equimolar concentration of alpha IR3 did not *affect* [IGFBP] production , ( 3 ) Des ( 1-3 ) IGF-I had no effect on IGFBP modulation , whereas at 10 nmol/L it enhanced BREC thymidine cell incorporation , and ( 4 ) 100 nmol/L insulin , which at this concentration can cross-react with the IGF-I receptor , did not modify the IGFBP pattern . Regulation IGFBP1 IGF1 9564845 500806 The aim of this study was to investigate the *effects* of and IL-1 on [IGFBP] production by ovine articular chondrocytes ( OAC ) and the roles of these IGFBPs in the regulation of proteoglycan synthesis . Regulation IGFBP1 IGF1 9814485 546355 To better understand how estradiol and IGF-I affect the IGF-I axis , a series of three studies was conducted to examine how estradiol and GH interact to affect the IGF-I axis and how *regulates* [IGFBP-1] and -3 during GH inhibition or receptor antagonism in adult female rhesus monkeys . Regulation IGFBP1 IGF2 10226803 610426 In the present study , we therefore characterized the IGFBPs secreted by bovine adrenocortical cells in primary culture , and investigated the *effect* of corticotropin ( ACTH ) and recombinant human IGF-I and on the regulation of [IGFBP] synthesis . Regulation IGFBP1 IGF2 10226803 610444 In contrast to their different steroidogenic potency , no significant difference in the stimulatory *effect* of IGF-I and on [IGFBP] secretion was found . Regulation IGFBP1 IGF2 11241178 791946 In the present study , we identified and characterized IGFBP synthesis in normal adult human adrenocortical cells in primary culture , and investigated the *effect* of ACTH and recombinant human on the regulation of [IGFBP] expression and secretion . Regulation IGFBP1 IGF2 1717510 166803 The IGF-I induced change in IGFBP levels was not a type I receptor mediated *effect* on [IGFBP] synthesis because ( a ) high concentrations of insulin did not mimic IGF-I 's effect ; Regulation IGFBP1 IGF2 7505463 237630 We have investigated the *regulation* by insulin , IGF-I , and , of [IGFBP] secretion in human endometrial stromal cells decidualized in vitro , and examined the interrelationship between the induced changes in IGFBP levels and the biological responses of stromal cells to IGFs . Regulation IGFBP1 IGF2 7505463 237652 The *effects* of IGF-I and on [IGFBP-1] secretion were biphasic , with initial stimulation ( 200-250 % ) that peaked at 1 and 10 ng/ml , respectively , followed by inhibition at higher concentrations ( half maximal inhibition at 3 ng/ml and 30 ng/ml , respectively ) . Regulation IGFBP1 IGF2 7505463 237657 These data indicate that endometrial stromal cell IGFBP-1 is regulated by insulin , at concentrations that are compatible with insulin acting via its own receptor , while the *effects* of IGF-I and on [IGFBP-1] secretion , are suggestive of their acting probably through the type I IGF receptor . Regulation IGFBP1 IGF2 7505466 237663 In contrast , [ Leu-27 ] , which interacts with the type II but not type I IGF receptor , had no *effect* on [IGFBP-1] protein levels or promoter activity . Regulation IGFBP1 IGF2 7505466 237668 When considered with previous data regarding expression of IGFBP-1 and the type I IGF receptor , our results suggest that *regulation* of [IGFBP-1] may play an as yet undefined role in fetal development and postnatal hepatic regeneration . Regulation IGFBP1 IGF2 7534698 297010 These data demonstrate that IGF peptide and glucocorticoid individually modulate IGFBP expression and indicate that glucocorticoid has distinct effects on *regulation* of [IGFBP] depending upon the particular IGFBP and the underlying mechanism of IGF regulation . Regulation IGFBP1 IGF2 8784106 380512 It had not been known if *affected* [IGFBP-I] production in these cells . Regulation IGFBP1 IGF2 8784106 380513 We examined the *effect* of on [IGFBP-I] production in human granulosa cells and compared this effect of IGF-II to similar effects of insulin and IGF-I . Regulation IGFBP1 IGF2 9439529 475009 In fact , ( 1 ) IGFBP mRNA levels were not modified after stimulation with 100 nmol/L IGF-I , ( 2 ) 100 nmol/L plus an equimolar concentration of alpha IR3 did not *affect* [IGFBP] production , ( 3 ) Des ( 1-3 ) IGF-I had no effect on IGFBP modulation , whereas at 10 nmol/L it enhanced BREC thymidine cell incorporation , and ( 4 ) 100 nmol/L insulin , which at this concentration can cross-react with the IGF-I receptor , did not modify the IGFBP pattern . Regulation IGFBP1 IL1A 7544275 318236 In the present study , we evaluated the *effects* of on [IGFBP] expression . Regulation IGFBP1 IL1A 7561640 328325 Since the IGF binding proteins (IGFBPs) modulate the effects of IGF-I , we examined the *effect* of and tumor necrosis factor-alpha (TNF-alpha) on [IGFBP] production by normal human articular chondrocytes in primary culture . Regulation IGFBP1 IL1A 9564845 500807 The aim of this study was to investigate the *effects* of IGF-I and on [IGFBP] production by ovine articular chondrocytes ( OAC ) and the roles of these IGFBPs in the regulation of proteoglycan synthesis . Regulation IGFBP1 IL1B 10965886 728066 Our data demonstrate that the MAP kinase signal transduction pathway plays an important role in the *regulation* of [IGFBP-1] synthesis by . Regulation IGFBP1 IL1B 15932926 1440423 The most marked *effect* of was the induction of [IGF binding protein-1] protein in stromal cells close to the apical surface , whereas cyclooxygenase-1 was down-regulated in the glandular epithelium . Regulation IGFBP1 INHBA 9116154 414182 The addition of increasing concentrations of the putative activin binding protein , follistatin , produced dose dependent reversal of the *effect* on [IGFBP] transcripts ( IGFBP-5 > IGFBP-4 ) . Regulation IGFBP1 INHBA 9435438 482540 We studied the *effects* of interferon-gamma (IFN gamma) and , which decrease progesterone accumulation , on granulosa cell [IGFBP] production and apoptosis . Regulation IGFBP1 INS 10326624 612836 [IGF BP-1] release was not *affected* by and IGF-I in the presence of both sera . Regulation IGFBP1 INS 10671946 676862 We conclude that in hyperthyroidism thyroid hormones directly increase fasting IGFBP-1 concentration but acute *regulation* of [IGFBP-1] by is normal and that elevated fasting phosphorylated IGFBP-1 concentration is associated with insulin resistance . Regulation IGFBP1 INS 10973497 730948 negatively *regulates* expression of the insulin-like growth factor binding protein 1 ( [IGFBP-1] ) gene by means of an insulin-responsive element (IRE) that also contributes to glucocorticoid stimulation of this gene . Regulation IGFBP1 INS 11251062 793833 IGF-I bioavailability was , in part , regulated by IGFBP-1 , but maximal changes in IGF-I and [IGFBP-1] were *independent* of plasma and glucose.5 . Regulation IGFBP1 INS 11443175 833825 We conclude that inhibition of PI-3 kinase by wortmannin fails to abolish stimulatory effect of insulin on progesterone production or inhibitory *effect* of on [IGFBP-1] production in cultured human ovarian cells . Regulation IGFBP1 INS 11672436 872455 This mechanism has been proposed to underlie *action* on G6Pase and [IGFBP-1] gene transcription . Regulation IGFBP1 INS 12176668 977199 Since [IGFBP-1] is acutely *regulated* by , this could have important consequences in hyperinsulinaemic and insulin-resistant states . Regulation IGFBP1 INS 1283982 207635 It was concluded that women with PCOS have normal serum IGF-1 concentrations but [IGFBP-1] levels , *regulated* by , are low . Regulation IGFBP1 INS 12914928 1129827 However , we recently found that the *regulation* of the [IGFBP1] but not the PEPCK or G6Pase genes by was sensitive to rapamycin , an inhibitor of mTOR . Regulation IGFBP1 INS 1370614 179471 These results demonstrate divergent *regulation* of [IGFBP-1] by phorbol esters and and indicate that protein kinase C may play a critical role in the regulation of IGFBP-1 and modulation IGF bioactivity in metabolic disease . Regulation IGFBP1 INS 1375600 188208 In this study , we defined [IGFBP-1] *regulation* by in upper and lower body obesity , conditions associated with insulin resistance and chronic hyperinsulinemia . Regulation IGFBP1 INS 1383070 198359 Since insulin-like growth factor I (IGF-I) has been shown to stimulate nerve regeneration , and [IGF binding protein-1] is acutely *regulated* by plasma we have investigated the relationships between plasma IGF-I , IGFBP-1 , glucose and insulin in Type 1 ( insulin dependent ) diabetic patients with peripheral polyneuropathy . Regulation IGFBP1 INS 1384818 200661 These results show that the gene expression of IGF-I and [IGFBP-1] is differently *regulated* by glucocorticoids and in primary cultures of rat hepatocytes . Regulation IGFBP1 INS 1385468 200783 Since insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) are believed to be involved in endometrial differentiation , and *regulates* [IGFBP] production in a variety of cells , we have investigated the modulatory roles of EGF , progesterone , and insulin on IGFBP secretion by long term cultures of human endometrial stromal cells . Regulation IGFBP1 INS 15070833 1272810 During pregnancy , the , which are known to be critically involved in placental development , are *controlled* by a binding [protein-IGFBP-1] produced by maternal decidualized endometrium . Regulation IGFBP1 INS 15736102 1378469 During refeeding after nutritional deprivation the [IGFBP-1] *response* to was restored in the individuals with diabetes . Regulation IGFBP1 INS 16002526 1452878 Here we examined the role of IRS dependent and -independent mechanisms in mediating and glucocorticoids *effects* on [IGFBP-1] promoter activity . Regulation IGFBP1 INS 16002526 1452880 These studies indicate that glucocorticoids and IRS associated factors function together to mediate effects of insulin and glucocorticoids on promoter activity and that glucocorticoid treatment creates a complex environment in which *regulates* [IGFBP-1] expression through both IRS dependent and IRS independent mechanisms . Regulation IGFBP1 INS 16455781 1547958 In this study we examined *regulation* of [IGFBP-1] in both subconfluent and confluent hepatocytes . Regulation IGFBP1 INS 16600022 1556427 Pharmacological inhibition of GSK3 mimics the *effect* of on Phosphoenolpyruvate Carboxykinase ( PEPCK ) , Glucose-6 Phosphatase (G6Pase) and [IGF binding protein-1 (IGFBP1)] gene expression . Regulation IGFBP1 INS 16801575 1579403 [IGF binding protein (IGFBP)-1] is negatively *regulated* by . Regulation IGFBP1 INS 1690745 128480 This study investigated the direct *effects* of on [IGFBP-1] production in vitro . Regulation IGFBP1 INS 1690745 128481 Monoclonal antibody studies indicated that the suppressive *effect* of on [IGFBP-1] synthesis was mediated through specific interaction with the insulin receptor . Regulation IGFBP1 INS 1697605 139557 Cultured human decidual cells release three IGF-BPs with 24,000 , 30,000 , and 34,000 Mr. Using ligand blot analysis and an RIA for the 30,000-Mr form ( IGF-BP-1 ) , we examined the *effects* of IGF-I ( 10-1,000 ng/ml ) , ( 10-10,000 ng/ml ) , and relaxin ( 10-250 ng/ml ) on decidual cell [IGF-BP] release after 120 h of hormone exposure . Regulation IGFBP1 INS 1698676 141603 Previous studies showed that levels of [IGFBP-1] are *regulated* by . Regulation IGFBP1 INS 17032741 1630817 In contrast , the activation of PI 3-kinase is required for *regulation* of [IGFBP1] under all conditions tested . Regulation IGFBP1 INS 17088407 1644083 This study suggests that the major inhibitory *role* of in the regulation of liver [IGFBP-1] production in mammals is not found in salmon . Regulation IGFBP1 INS 1710998 158293 The production was inhibited by clomiphene and progesterone , whereas estrogen , cortisol and had no *effect* on [IGFBP-1] secretion . Regulation IGFBP1 INS 1717456 166767 [IGFBP-1] mRNA levels were similarly *affected* by 100 nM , falling to 45 % of control values after 2 h , and to 9 % of control values after 4 h of incubation with this hormone . Regulation IGFBP1 INS 1719386 169622 To understand the molecular basis for this regulation , we have examined the *effects* of on [IGFBP-1] and IGFBP-1 mRNA in the H4-II-E cell line derived from the well differentiated H35 rat hepatoma . Regulation IGFBP1 INS 1719386 169624 We propose that regulation of IGFBP-1 synthesis is an important component of the *regulation* of [IGFBP-1] by in vivo . Regulation IGFBP1 INS 18234122 1871286 The purpose of this study was to examine the *effect* of on expression and synthesis of [IGFBP-1] and IGFBP-2 in the baboon endometrium in vitro . Regulation IGFBP1 INS 18234122 1871290 The inhibitory *effects* of on [IGFBP-1] were more evident in explants of non-pregnant tissue or tissue away from the implantation site . Regulation IGFBP1 INS 18234122 1871294 differentially *regulates* endometrial [IGFBP-1] and IGFBP-2 secretion in the baboon . Regulation IGFBP1 INS 20216949 2223460 These results indicate that PQ-induced oxidative stress impairs insulin dependent mTOR activation and that this impairment probably causes inhibition of *dependent* repression of [IGFBP-1] expression . Regulation IGFBP1 INS 21642764 2599074 LAN did not modify the GH , , glucagon , glucose , and [IGFBP-1] *responses* to ARG . Regulation IGFBP1 INS 2542098 112200 The authors evaluated the *role* of in the regulation of serum levels of 34K [IGF-BP] in patients with polycystic ovarian disease ( PCOD ) . Regulation IGFBP1 INS 7505463 237631 We have investigated the *regulation* by , IGF-I , and IGF-II , of [IGFBP] secretion in human endometrial stromal cells decidualized in vitro , and examined the interrelationship between the induced changes in IGFBP levels and the biological responses of stromal cells to IGFs . Regulation IGFBP1 INS 7505463 237658 These data indicate that endometrial stromal cell [IGFBP-1] is *regulated* by , at concentrations that are compatible with insulin acting via its own receptor , while the effects of IGF-I and IGF-II on IGFBP-1 secretion , are suggestive of their acting probably through the type I IGF receptor . Regulation IGFBP1 INS 7505466 237666 The effects of IGF-I and IGF-II apparently occur as a result of binding to the type I IGF receptor , and are similar to the previously characterized suppressive *effects* of on [IGFBP-1] transcription mediated through the insulin receptor . Regulation IGFBP1 INS 7511134 250038 It is proposed that the specific secretion pattern of [IGFBP-1] is not directly dependent on body fat mass but is *regulated* by in both obese and non-obese patients . Regulation IGFBP1 INS 7511786 241695 *Effects* of on [IGFBP-1] gene transcription were not mimicked or antagonized by phorbol ester . Regulation IGFBP1 INS 7514335 241716 Hepatic expression of [IGFBP-1] is *regulated* at the level of gene transcription by in a dominant negative fashion , while glucocorticoids and cAMP analogues exert positive effects on hepatocellular IGFBP-1 mRNA . Regulation IGFBP1 INS 7520930 269255 The elevation of plasma IGFBP-1 immunoreactivity was associated with reduced concentrations of glucose and , the *regulators* of [IGFBP-1] in humans and rats . Regulation IGFBP1 INS 7521340 243690 We determined whether aging influences circulating insulin-like growth factor binding protein-1 ( IGFBP-1 ) concentrations and , if so , whether this effect is explained by altered *regulation* of [IGFBP-1] by . Regulation IGFBP1 INS 7521354 269310 IGF-I and IGFBP-3 are GH dependent , whereas [IGFBP-1] is *regulated* . Regulation IGFBP1 INS 7521354 269312 The aim of the present study was to examine the *effect* of on the hepatic secretion of [IGFBP-1] , IGFBP-3 , and IGF-I . Regulation IGFBP1 INS 7537614 300937 These data suggest that strongly *regulates* pre- and post-translational renal [IGF BP1] gene expression and implicate BP1 as an important determinant of IGF-I activity in diabetic kidney . Regulation IGFBP1 INS 7586625 329798 Uncoupling of the GH-IGF-I axis , and the attenuation of the inhibitory *effects* of on [IGFBP-1] , both contribute to the reduction in IGF-I levels and bioavailability , factors which may play an important role in post injury metabolism . Regulation IGFBP1 INS 7683312 216422 However , these *effects* of on [IGFBP-1] diminished with increasing glucose concentration . Regulation IGFBP1 INS 7683739 216564 Using SRIF plus sequential graded insulin infusions , the threshold peripheral ( = portal ) plasma insulin concentration for IGFBP-1 suppression was between 65 and 172 pmol/L. Subjects with insulin dependent diabetes mellitus ( IDDM ) showed a similar dose-response pattern , suggesting that *regulation* of [IGFBP-1] may be normal in IDDM . Regulation IGFBP1 INS 7687525 222452 In-vitro studies have shown that both and glucose independently *regulate* [IGFBP-1] secretion in an inverse manner . Regulation IGFBP1 INS 7687807 222523 To evaluate the short-term *effects* of growth hormone (GH) , and different levels of glycemia on insulin-like growth factors (IGF) I and II and [IGF binding proteins (IGFBP) 1] , 2 and 3 , we studied six GH-deficient adolescents during a night and the following day in the postabsorptive ( basal ) state followed by sequential euglycemic ( 5 mmol/l ) and hypoglycemic ( 3 mmol/l ) glucose clamps concomitant with an intravenous infusion ( starting at 24.00 h ) of GH ( 35 micrograms/h ) or saline . Regulation IGFBP1 INS 8636256 362243 Insulin receptor mediates inhibitory *effect* of , but not of insulin-like growth factor (IGF)-I , on [IGF binding protein 1 (IGFBP-1)] production in human granulosa cells . Regulation IGFBP1 INS 8636256 362245 Preincubation with antiinsulin receptor antibody IR-47-9 alleviated inhibitory *effect* of , but not of IGF-I on [IGFBP-1] production . Regulation IGFBP1 INS 8756536 377449 In addition , our findings suggest that GH modulates *regulation* of [IGFBP-1] transcription , possibly by altering the milieu of trans acting factors that interact with both the insulin response element and distinct upstream sites . Regulation IGFBP1 INS 8817651 344468 Additional studies are required to establish whether binding of any of these proteins to the IRE is important to the *regulation* of [hIGFBP-1] expression by and/or glucocorticoids . Regulation IGFBP1 INS 8865877 389039 This suggests that does not *affect* [IGFBP-1] production in this group of patients . Regulation IGFBP1 INS 9141538 428424 These relationships were accounted for by the effects of insulin , suggesting that *regulation* of [IGFBP-1] by may play a role in determining body composition in aging . Regulation IGFBP1 LPA 23790320 2824226 Both cyclooxygenase-2 and inducible NOS mediated *effect* on [IGFBP-1] and IL-10 expression . Regulation IGFBP1 MTOR 11784721 916786 We propose that these observations indicate that an dependent , but S6K independent mechanism *regulates* the suppression of [IGFBP-1] ( but not G6Pase ) gene expression by insulin . Regulation IGFBP1 MTOR 11942857 953540 Our results support the view that the insulin mediated repression of [IGFBP-1] gene expression is partly *dependent* , and demonstrate that H ( 2 ) O ( 2 ) selectively antagonizes mTOR dependent insulin action . Regulation IGFBP1 MTOR 16455781 1547965 In confluent hepatocytes , insulin could not activate the phosphatidylinositol 3-kinase ( PI3 kinase ) -Akt-Foxo1/Foxo3 pathway , but still inhibited [IGFBP-1] gene expression in an *dependent* manner . Regulation IGFBP1 NOS2 23790320 2824227 Both cyclooxygenase-2 and mediated LPA *effect* on [IGFBP-1] and IL-10 expression . Regulation IGFBP1 PAEP 9584945 478187 We propose that may have immunosuppressive properties and that [IGFBP-1] may *regulate* trophoblast migration within the uterine endometrium . Regulation IGFBP1 PGR 15987820 1452612 In the present study , we investigated the *role* of two transcription factors , and a member of the forkhead box class O family of transcription factors ( FOXO1A ) , in the regulation of the [IGFBP1] gene in endometrial cells . Regulation IGFBP1 PGR 7520702 269179 Identification of a distal regulatory sequence of the human [IGFBP-1] gene promoter and *regulation* by the in a human endometrial adenocarcinoma cell line . Regulation IGFBP1 PRKAA1 11302732 803421 The *role* of , an important signaling system in lipid and carbohydrate metabolism , in regulating [IGFBP-1] was studied in H4-II-E rat hepatoma cells . Regulation IGFBP1 PRKAA2 11302732 803422 The *role* of , an important signaling system in lipid and carbohydrate metabolism , in regulating [IGFBP-1] was studied in H4-II-E rat hepatoma cells . Regulation IGFBP1 PRKAB1 11302732 803423 The *role* of , an important signaling system in lipid and carbohydrate metabolism , in regulating [IGFBP-1] was studied in H4-II-E rat hepatoma cells . Regulation IGFBP1 PRKAB2 11302732 803424 The *role* of , an important signaling system in lipid and carbohydrate metabolism , in regulating [IGFBP-1] was studied in H4-II-E rat hepatoma cells . Regulation IGFBP1 PRKAG1 11302732 803425 The *role* of , an important signaling system in lipid and carbohydrate metabolism , in regulating [IGFBP-1] was studied in H4-II-E rat hepatoma cells . Regulation IGFBP1 PRKAG2 11302732 803426 The *role* of , an important signaling system in lipid and carbohydrate metabolism , in regulating [IGFBP-1] was studied in H4-II-E rat hepatoma cells . Regulation IGFBP1 PTGS2 23790320 2824228 Both and inducible NOS mediated LPA *effect* on [IGFBP-1] and IL-10 expression . Regulation IGFBP1 PTH 1703477 151346 Agents that elevate intracellular cAMP by different mechanisms [ ( Bu ) 2cAMP , forskolin , and isobutylmethylxanthine ] mimicked the *effect* of and PTHrP on [IGFBP] synthesis . Regulation IGFBP1 PTHLH 1703477 151347 Agents that elevate intracellular cAMP by different mechanisms [ ( Bu ) 2cAMP , forskolin , and isobutylmethylxanthine ] mimicked the *effect* of PTH and on [IGFBP] synthesis . Regulation IGFBP1 RLN1 1697605 139553 Cultured human decidual cells release three IGF-BPs with 24,000 , 30,000 , and 34,000 Mr. Using ligand blot analysis and an RIA for the 30,000-Mr form ( IGF-BP-1 ) , we examined the *effects* of IGF-I ( 10-1,000 ng/ml ) , insulin ( 10-10,000 ng/ml ) , and ( 10-250 ng/ml ) on decidual cell [IGF-BP] release after 120 h of hormone exposure . Regulation IGFBP1 RLN2 1697605 139554 Cultured human decidual cells release three IGF-BPs with 24,000 , 30,000 , and 34,000 Mr. Using ligand blot analysis and an RIA for the 30,000-Mr form ( IGF-BP-1 ) , we examined the *effects* of IGF-I ( 10-1,000 ng/ml ) , insulin ( 10-10,000 ng/ml ) , and ( 10-250 ng/ml ) on decidual cell [IGF-BP] release after 120 h of hormone exposure . Regulation IGFBP1 RLN3 1697605 139555 Cultured human decidual cells release three IGF-BPs with 24,000 , 30,000 , and 34,000 Mr. Using ligand blot analysis and an RIA for the 30,000-Mr form ( IGF-BP-1 ) , we examined the *effects* of IGF-I ( 10-1,000 ng/ml ) , insulin ( 10-10,000 ng/ml ) , and ( 10-250 ng/ml ) on decidual cell [IGF-BP] release after 120 h of hormone exposure . Regulation IGFBP1 SIRT1 16236254 1470669 FoxO dependent and -independent mechanisms mediate *effects* on [IGFBP-1] gene expression . Regulation IGFBP1 STAT5B 17426286 1742282 Here we show that *plays* a critical role in the GH-regulated inhibition of [IGF binding protein-1] gene transcription by impairing the actions of the FoxO1 transcription factor on the IGF binding protein-1 promoter . Regulation IGFBP1 TGFB1 10830291 697410 In conclusion , vascular endothelial growth factor and *regulate* [IGFBP] expression in bovine aortic endothelial cells . Regulation IGFBP1 TNF 7522842 272141 Because basal secretion of IGFBPs is very low in MC3T3-E1 cells , *effects* of on [IGFBP] secretion were studied in cultures in which IGFBP-4 expression was increased by calcitriol ( 1,25 ( OH ) 2D3 ) treatment . Regulation IGFBP1 TNF 7561640 328324 Since the IGF binding proteins (IGFBPs) modulate the effects of IGF-I , we examined the *effect* of IL-1 alpha and on [IGFBP] production by normal human articular chondrocytes in primary culture . Regulation IGFBP1 UGCG 12379498 997287 We have studied the *effects* of on IGF and [IGFBP] expression at the local level of the growth plate , using non-radioactive in situ hybridization . Regulation IGFBP1 VEGFA 10830291 697411 In conclusion , and transforming growth factor-beta1 *regulate* [IGFBP] expression in bovine aortic endothelial cells . Regulation IGFBP2 TNF 7522842 272142 Because basal secretion of IGFBPs is very low in MC3T3-E1 cells , *effects* of on [IGFBP] secretion were studied in cultures in which IGFBP-4 expression was increased by calcitriol ( 1,25 ( OH ) 2D3 ) treatment . Regulation IGFBP2 TNF 7561640 328326 Since the IGF binding proteins (IGFBPs) modulate the effects of IGF-I , we examined the *effect* of IL-1 alpha and on [IGFBP] production by normal human articular chondrocytes in primary culture . Regulation IGFBP3 PLAU 17121915 1652267 The specific *role* of in anti-invasive activity of [IGFBP-3] was further confirmed in NSCLC cells , in which uPA expression/activity was suppressed by the transfection with synthetic small interfering RNA or by the treatment with uPA inhibitor or induced by the infection with an adenoviral vector . Regulation IGFBP3 RARB 16760641 1590434 [IGFBP-3] gene expression by 9cRA is mediated by a distinct DR-8 RARE located in the proximal region of the IGFBP promoter and *involves* the , a putative tumor suppressor in NSCLC . Regulation IGFBP3 TNF 7522842 272143 Because basal secretion of IGFBPs is very low in MC3T3-E1 cells , *effects* of on [IGFBP] secretion were studied in cultures in which IGFBP-4 expression was increased by calcitriol ( 1,25 ( OH ) 2D3 ) treatment . Regulation IGFBP3 TNF 7561640 328328 Since the IGF binding proteins (IGFBPs) modulate the effects of IGF-I , we examined the *effect* of IL-1 alpha and on [IGFBP] production by normal human articular chondrocytes in primary culture . Regulation IGFBP4 IL1B 10433204 633938 The inhibitory *effect* of on ovarian [IGFBP-4] and -5 expression was almost completely reversed in the presence of IL-1 receptor antagonist , suggesting mediation via a specific IL-1 receptor . Regulation IGFBP4 TNF 10192430 603653 In contrast , [IGFBP4] was not regulated in *response* to IL-6 , , PDGF BB , bFGF , TGF-beta or the cAMP agonist , forskolin . Regulation IGFBP4 TNF 7522842 272140 In the present study we have investigated the *effect* of on the secretion of insulin-like growth factor I (IGF-I) and [IGF binding protein 4 (IGFBP-4)] by clonal mouse osteoblasts ( MC3T3-E1 cells ) using subconfluent in vitro cultures and serum-free conditions . Regulation IGFBP4 TNF 7522842 272144 Because basal secretion of IGFBPs is very low in MC3T3-E1 cells , *effects* of on [IGFBP] secretion were studied in cultures in which IGFBP-4 expression was increased by calcitriol ( 1,25 ( OH ) 2D3 ) treatment . Regulation IGFBP4 TNF 7561640 328330 Since the IGF binding proteins (IGFBPs) modulate the effects of IGF-I , we examined the *effect* of IL-1 alpha and on [IGFBP] production by normal human articular chondrocytes in primary culture . Regulation IGFBP5 ANO1 23576565 2799907 *regulates* growth and [IGFBP5] in gastrointestinal stromal tumors . Regulation IGFBP5 IL1B 10433204 633939 The inhibitory *effect* of on ovarian [IGFBP-4 and -5] expression was almost completely reversed in the presence of IL-1 receptor antagonist , suggesting mediation via a specific IL-1 receptor . Regulation IGFBP5 TNF 7522842 272145 Because basal secretion of IGFBPs is very low in MC3T3-E1 cells , *effects* of on [IGFBP] secretion were studied in cultures in which IGFBP-4 expression was increased by calcitriol ( 1,25 ( OH ) 2D3 ) treatment . Regulation IGFBP5 TNF 7561640 328332 Since the IGF binding proteins (IGFBPs) modulate the effects of IGF-I , we examined the *effect* of IL-1 alpha and on [IGFBP] production by normal human articular chondrocytes in primary culture . Regulation IGFBP6 TNF 7522842 272146 Because basal secretion of IGFBPs is very low in MC3T3-E1 cells , *effects* of on [IGFBP] secretion were studied in cultures in which IGFBP-4 expression was increased by calcitriol ( 1,25 ( OH ) 2D3 ) treatment . Regulation IGFBP6 TNF 7561640 328334 Since the IGF binding proteins (IGFBPs) modulate the effects of IGF-I , we examined the *effect* of IL-1 alpha and on [IGFBP] production by normal human articular chondrocytes in primary culture . Regulation IGFBP7 TNF 7522842 272147 Because basal secretion of IGFBPs is very low in MC3T3-E1 cells , *effects* of on [IGFBP] secretion were studied in cultures in which IGFBP-4 expression was increased by calcitriol ( 1,25 ( OH ) 2D3 ) treatment . Regulation IGFBP7 TNF 7561640 328336 Since the IGF binding proteins (IGFBPs) modulate the effects of IGF-I , we examined the *effect* of IL-1 alpha and on [IGFBP] production by normal human articular chondrocytes in primary culture . Regulation IGHG3 HRH1 21885652 2510446 Translation inhibition of [hdc] decreased the number of hcrt neurons in a *dependent* manner . Regulation IGKV1-27 TNF 15862966 1401049 [A20] gene expression is *regulated* by , Vitamin D and androgen in prostate cancer cells . Regulation IGKV1-27 TNF 16105945 1448387 The synergistic interaction between fXa and was also *involved* in the inhibition of [A20] and IkappaBalpha expression in the IkappaB kinase-NF-kappaB pathway . Regulation IHH CCND1 11748145 889575 Finally , expression of cyclin D1 is markedly downregulated when either Ihh or Smo activity is removed from chondrocytes , indicating that [Ihh] *regulates* chondrocyte proliferation at least in part by modulating the transcription of . Regulation IKBKB IL1B 12934647 1132842 Salicylate inhibited the and TNF-alpha induced COX-2 expressions , *regulated* the activation of ERK , [IKK] and IkappaB degradation , and the subsequent activation of NF-kappaB , in neonatal rat ventricular cardiomyocytes . Regulation IKBKB MAP2K6 16584774 1665834 Together , we interpret these data as demonstrating that the activation caused by loss of Gimap5 is a cell intrinsic phenomenon caused , in part , by a *dependent* activation of [IKK] . Regulation IKBKB TLR7 22473004 2589097 NLRC5 ablation reduces MHC class I expression , and enhances [IKK] and IRF3 phosphorylation in *response* to stimulation or viral infection . Regulation IKBKB TNF 11359906 816589 The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2 dependent [IKK] recruitment to tumor necrosis factor (TNF) receptor 1 in *response* to . Regulation IKBKB TNF 11359906 816595 In *response* to the proinflammatory cytokine , [IKK] is activated after being recruited to the TNF receptor 1 (TNF-R1) complex via TNF receptor associated factor 2 (TRAF2) . Regulation IKBKB TNF 11429546 831660 The molecular mechanism that underlies [IKK] activation in *response* to is still unknown . Regulation IKBKB TNF 16126728 1467076 This pathway is initiated by *dependent* phosphorylation of T loop serines in [IKKbeta] , which greatly stimulates IkappaB kinase activity . Regulation IKBKB TNF 16611882 1545341 Similarly , IKKgamma-delta mediates [IKK] kinase activity and downstream NF-kappaB dependent transcription in *response* to and the NF-kappaB inducing kinase-IKKalpha signaling pathway . Regulation IKBKB TNF 17244613 1710254 Our results therefore demonstrate that NEMO and IKKalpha can form a functional [IKK complex] that activates the classical NF-kappaB pathway in *response* to IL-1 but not . Regulation IKBKB TNF 18037881 1832656 Studies in non-malignant epithelial cells show that MUC1 is recruited to the TNF-R1 complex and interacts with [IKKbeta-IKKgamma] in *response* to stimulation . Regulation IKBKB TNF 19202066 2044210 We also found that high glucose induced the O-GlcNAcylation of IKKbeta and sustained the *dependent* [IKKbeta] activity . Regulation IKBKB TNF 9710600 526827 Our studies now demonstrate that HTLV-1 Tax activates the recently identified cellular kinases IkappaB kinase alpha (IKKalpha) and [IKKbeta] , which normally phosphorylate IkappaB alpha on both of its N-terminal regulatory serines in *response* to and interleukin-1 (IL-1) stimulation . Regulation IKBKB TNF 9819420 547290 MEKK1 is activated by tumor necrosis factor alpha (TNF-alpha) and interleukin-1 and can potentiate the stimulatory *effect* of on [IKK] and NF-kappaB activation . Regulation IKBKG IL1B 12934647 1132844 Salicylate inhibited the and TNF-alpha induced COX-2 expressions , *regulated* the activation of ERK , [IKK] and IkappaB degradation , and the subsequent activation of NF-kappaB , in neonatal rat ventricular cardiomyocytes . Regulation IKBKG IL1B 17009010 1765510 In this report , we show an enhanced activation of CK2 bound to [IKKgamma] or the p65 subunit of the NF-kappaB in *response* to stimulation of intestinal epithelial cells . Regulation IKBKG MAP2K6 16584774 1665841 Together , we interpret these data as demonstrating that the activation caused by loss of Gimap5 is a cell intrinsic phenomenon caused , in part , by a *dependent* activation of [IKK] . Regulation IKBKG TLR7 22473004 2589107 NLRC5 ablation reduces MHC class I expression , and enhances [IKK] and IRF3 phosphorylation in *response* to stimulation or viral infection . Regulation IKBKG TNF 11359906 816590 The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2 dependent [IKK] recruitment to tumor necrosis factor (TNF) receptor 1 in *response* to . Regulation IKBKG TNF 11359906 816596 In *response* to the proinflammatory cytokine , [IKK] is activated after being recruited to the TNF receptor 1 (TNF-R1) complex via TNF receptor associated factor 2 (TRAF2) . Regulation IKBKG TNF 11429546 831661 The molecular mechanism that underlies [IKK] activation in *response* to is still unknown . Regulation IKBKG TNF 16611882 1545342 Similarly , IKKgamma-delta mediates [IKK] kinase activity and downstream NF-kappaB dependent transcription in *response* to and the NF-kappaB inducing kinase-IKKalpha signaling pathway . Regulation IKBKG TNF 17244613 1710256 Our results therefore demonstrate that NEMO and IKKalpha can form a functional [IKK complex] that activates the classical NF-kappaB pathway in *response* to IL-1 but not . Regulation IKBKG TNF 18037881 1832657 Studies in non-malignant epithelial cells show that MUC1 is recruited to the TNF-R1 complex and interacts with [IKKbeta-IKKgamma] in *response* to stimulation . Regulation IKBKG TNF 19885854 2188229 Transcriptional *regulation* of [IER3IP1] gene by and Sp family proteins . Regulation IKBKG TNF 9819420 547291 MEKK1 is activated by tumor necrosis factor alpha (TNF-alpha) and interleukin-1 and can potentiate the stimulatory *effect* of on [IKK] and NF-kappaB activation . Regulation IL10 ALOX5 8722494 373690 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL10 CD14 18049335 1833198 Patients were separated into 2 groups on the basis of the monocyte [IL-10] *response* : either increasing or decreasing IL-10 expression from preimmunization ( week 0 ) to week 16 blood draws . Regulation IL10 EPHB2 11971021 933499 Studies using rIL-10 and IL-10 gene-deficient mice demonstrated that the inhibitory effect of ERK on CpG DNA mediated IL-12 production is indirect , due to the *role* of in mediating [IL-10] production . Regulation IL10 EPHB2 12112010 963583 IL-6 induced M1 differentiation also induces expression of the anti-inflammatory cytokine IL-10 , and p38 inhibition potentiates this increase in [IL-10] expression in an *dependent* manner . Regulation IL10 EPHB2 16824602 1666066 A specific inhibitor , U0126 , as well as PI3K inhibitors , differentially *regulated* [IL-10] and IL-12 p70 productions . Regulation IL10 EPHB2 17458858 1743184 Syk dependent activation *regulates* IL-2 and [IL-10] production by DC stimulated with zymosan . Regulation IL10 EPHB2 20511709 2270506 Both LPS and GA stimulated the production of IL-6 , [IL-10] , IL12p70 and TNFalpha in a p38- and/or *dependent* manner . Regulation IL10 EPHB2 24737107 2943033 TLR mediated STAT3 and activation *controls* [IL-10] secretion by human B cells . Regulation IL10 IL1B 11179490 784753 We explored the *regulation* of [IL-10] production by TNF-alpha , , IL-6 , IL-8 , and IFN-gamma in human colon carcinoma COLO205 cells . Regulation IL10 IL1B 11777281 890672 Concentrations of IL-2 induced [IL-10] and soluble Fas ligand ( sFasL ) were not *affected* by . Regulation IL10 IL1B 12010759 941266 We conclude that [IL-10] modulates the febrile response by acting in the periphery or in the brain dependent on the primary site of inflammation and that its mechanism of action most likely *involves* inhibition of local production . Regulation IL10 IL1B 12880609 1115759 stimulation increased IL-6 and IL-8 , but did not *affect* IL-4 and [IL-10] production . Regulation IL10 IL1B 14617515 1200661 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL10 IL1B 14977992 1213346 Mycobacterial purified protein derivatives stimulate innate immunity : Malawians show enhanced tumor necrosis factor alpha , , and [IL-10] *responses* compared to those of adolescents in the United Kingdom . Regulation IL10 IL1B 14977992 1213350 To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom , we examined 24-h tumor necrosis factor alpha , , and [IL-10] *responses* to mycobacterial purified protein derivatives ( PPDs ) . Regulation IL10 IL1B 16499573 1528912 When infected HeLa cells were co-cultured with THP-1 cells , IL-6 and IL-8 secretion was sustained , expression followed a bell shaped curve and [IL-10] , IL-12p70 and TNF-alpha synthesis was down *regulated* . Regulation IL10 IL1B 9360229 462327 Decidual cells in culture produced [IL-10] in *response* to , but chorion and amnion cells produced no IL-10 protein . Regulation IL10 IL1R2 2969889 95572 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL10 JAG1 21490151 2422914 In this article , we demonstrate that LT acts as a highly effective adjuvant when administered parenterally , promoting Ag-specific IL-17 , as well as IFN-? , IL-4 , and [IL-10] production in *response* to coadministered . Regulation IL10 NT5E 21057730 2344656 *dependent* regulation of interferon aA and [interleukin-10] in the inflamed mucosa . Regulation IL10 STAT4 19001140 1991077 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL10 TLR7 16461893 1522733 In *response* to signals , MKP-1-deficient macrophages produced 5- to 10-fold higher [IL-10] , which could be blocked by a p38 MAPK inhibitor . Regulation IL10 TLR7 17034424 1683242 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL10 TLR7 17114424 1651409 Macrophages and myeloid dendritic cells , but not plasmacytoid dendritic cells , produce [IL-10] in *response* to MyD88- and TRIF dependent signals , and TLR independent signals . Regulation IL10 TLR7 18201931 1883772 Using an in vitro model , we studied how IC solubility , complement activation products , and ligands could *affect* [IL-10] production by human monocytes stimulated with ICs . Regulation IL10 TLR7 18312842 1879636 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL10 TLR7 20384871 2240000 We found that CD25 ( + ) B cells secreted higher levels of IL-6 , [IL-10] and INFgamma in *response* to different , and were better at presenting alloantigen to CD4 ( + ) T cells . Regulation IL10 TLR7 20471186 2294408 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL10 TLR7 21106540 2389851 Mouse macrophages produce IL-12 and [IL-10] in *response* to ligands such as LPS , CpG , Poly I:C and Malp2 . Regulation IL10 TLR7 21971520 2512683 In marked contrast , TRAF3 ( -/- ) B cells made elevated amounts of TNF and IL-6 protein , as well as [IL-10] and IP-10 mRNA , in *response* to ligands . Regulation IL10 TLR7 23883517 2870766 Macrophages and DCs generated from AMPKa1-deficient mice produced higher levels of proinflammatory cytokines and decreased production of the anti-inflammatory cytokine [IL-10] in *response* to and CD40 stimulation as compared with WT cells . Regulation IL10 TLR7 24737107 2943087 These results yield insights into the mechanisms by which signaling *regulates* [IL-10] production in B cells and how type I IFN modulates TLR mediated IL-10 production by B cells , therefore providing potential targets to modulate the function of IL-10 producing B cells . Regulation IL10 TLR7 24771857 2937097 At the cellular level , Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower TNF-a and higher [IL-10] in *response* to ligands than did their WT counterparts . Regulation IL10 TNF 11008981 735851 Left atrial femoral bypass significantly reduced the duration of visceral ischemia ( p < .05 ) and the systemic , p75 , and [IL-10] *responses* ( p < .05 ) . Regulation IL10 TNF 11108135 756678 The anti-inflammatory cytokine [IL-10] is up-regulated in *response* to suggesting a control mechanism of inflammation . Regulation IL10 TNF 11292741 801080 Our data show that , whereas TNF-alpha and IL-1 have a minor role in the induction of TFA by monocytes cultured on a fibrin matrix , but not IL-1 *plays* an important role in the induction of [IL-10] by these cells . Regulation IL10 TNF 11518190 851509 ( ii ) In contrast , had no *effect* on [IL-10] and only a modest effect on IL-1beta and IL-6 levels in these cells . Regulation IL10 TNF 11895951 920812 To understand the mechanism ( s ) implicated in the regulation of the synthesis and release of IL-10 during early infection , we investigated the autocrine effects of IL-6 , IL-12 , , and IL-10 itself , as well as the exocrine *effect* of IFN-gamma on the production of macrophage derived [IL-10] with lipoprotein as a stimulant . Regulation IL10 TNF 14977992 1213345 Mycobacterial purified protein derivatives stimulate innate immunity : Malawians show enhanced alpha , interleukin-1beta (IL-1beta) , and [IL-10] *responses* compared to those of adolescents in the United Kingdom . Regulation IL10 TNF 14977992 1213349 To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom , we examined 24-h alpha , interleukin-1beta (IL-1beta) , and [IL-10] *responses* to mycobacterial purified protein derivatives ( PPDs ) . Regulation IL10 TNF 15003809 1217308 An endotoxicosis model that utilizes LPS and d-galactosamine to induce mortality by TNFalpha/TNFR1 dependent hepatocyte apoptosis was used to assess production , apoptotic signaling , and *effects* on the production of IL-6 and [IL-10] . Regulation IL10 TNF 15361231 1293658 IFN-gamma and play a role in both protective immunity and the pathology of the infection , and the inflammatory disease may be *regulated* by [IL-10] and transforming growth factor-beta . Regulation IL10 TNF 16157517 1499762 Together , these data suggest that both the PMN and the macrophage are required to induce inflammation seen here , however , macrophage not PMN *regulate* the release of [IL-10] , independent of local changes in . Regulation IL10 TNF 16369191 1505147 These results suggest that FN protected against GalN/LPS induced liver failure by a mechanism involving inhibition of NF-kappaB activation , which caused down-regulation of and *involved* up-regulation of [IL-10] , and elevation of Bcl-xL induced a blockage of apoptotic signals , by which apoptosis of hepatocytes caused by GalN/LPS was suppressed . Regulation IL10 TNF 16580226 1550192 Treatment of monoclonal antibodies against cytokines showed that IFN-gamma and [interleukin 10 (IL-10)] were involved in maintenance of growth of S. Typhimurium mutant on day 10 after infection , and IFN-gamma , and transforming growth factor-beta ( TGF-beta ) were *involved* in maintenance of growth of this bacterium on day 30 after infection . Regulation IL10 TNF 17537727 1767286 Short-term treatment of RAW264.7 macrophages with adiponectin increases tumor necrosis factor-alpha (TNF-alpha) expression via ERK1/2 activation and Egr-1 expression : *role* of in adiponectin stimulated [interleukin-10] production . Regulation IL10 TNF 17584982 1815868 In this work , we studied the role of changes in norepinephrine ( NE ) level on the lipopolysaccharide (LPS) evoked and [interleukin (IL)-10] *response* both in the plasma and in the hippocampus of mice . Regulation IL10 TNF 19026560 2001498 [IL-10] overexpression differentially affects cartilage matrix gene expression in *response* to in human articular chondrocytes in vitro . Regulation IL10 TNF 19898617 2161708 Maternal protozoan infections was independently associated with reduced infant [IL10] in *response* to PHA and to LPS as well as reduced and IFN-gamma in response to PHA . Regulation IL10 TNF 20303596 2230497 Distinctively , the PKA inhibitor H89 blocked the suppressive effect of isoproterenol on production , as well as its stimulatory *effect* on [IL-10] induction , in LPS stimulated macrophages . Regulation IL10 TNF 20979991 2365422 The *role* of for [interleukin-10] production by murine dendritic cells . Regulation IL10 TNF 20979991 2365425 In the present study , we examined the *role* of in [interleukin (IL)-10] production by dendritic cells (DCs) using bone-marrow derived DCs from wild type ( WT ) and TNF-a knockout ( TNF-a ( -/- ) ) mice . Regulation IL10 TNF 21806874 2462486 To investigate the *effect* of on release of IL-6 , [IL-10] and histamine from mast cells and to explore its potential signal transduction pathway . Regulation IL10 TNF 22693231 2638688 Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß) , interleukin 6 (IL-6) , [interleukin 10 (IL-10)] , interleukin 12 (IL-12) , and *responses* to Toll-like receptor (TLR) 3 and TLR4 stimulation . Regulation IL10 TNF 23432860 2744429 These results suggest that the high circulating levels and the inadequate [IL-10] *response* in the SM patients carrying TNF2 allele could have contributed to the development of severe falciparum malarial disease . Regulation IL10 TNF 23708964 2806395 Patient whole blood cells failed to secrete IL-6 in response to IL-1ß , Pam2CSK4 , showed reduced responses to LPS and PMA/Ionomycin , and lacked [IL-10] production in *response* to . Regulation IL10 TNF 24252254 2898064 The suppression of circulating levels of , MCP-1 and IL-8 and their enhancing *effect* on [IL-10] and TGF-ß production were more pronounced in male patients . Regulation IL10 TNF 3486658 59978 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL10 TNF 3491252 65983 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL10 TNF 7547677 327051 On the basis of these results , we conclude that is *involved* in the up-regulation of its antagonist [IL-10] . Regulation IL10 TNF 7578738 333347 Since [interleukin-10 (IL-10)] *controls* the production of and this latter cytokine has a deleterious effect on neuronal cells , we determined the levels of both cytokines in cerebrospinal fluid (CSF) from children with bacterial meningitis . Regulation IL10 TNF 7589088 333988 Lipopolysaccharide induced [interleukin-10] in mice : *role* of endogenous . Regulation IL10 TNF 7964475 279561 *Regulation* of [interleukin 10] release by in humans and chimpanzees . Regulation IL10 TNF 7964475 279564 To assess the *role* of in the induction of [IL-10] in endotoxemia , four healthy men were studied after a bolus intravenous injection of recombinant human TNF ( 50 micrograms/m2 ) . Regulation IL10 TNF 7986155 282351 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL10 TNF 8258695 238784 Predominant *role* of in human monocyte [IL-10] synthesis . Regulation IL10 TNF 8344757 226490 LPS , IL-1 alpha , and strongly enhanced the release of IL-6 by RCC cells , but only marginally *affected* [IL-10] production in colon-carcinoma cells . Regulation IL10 TNF 8835203 386085 Interleukin 1 beta , interleukin 6 , alpha , and [interleukin 10] *responses* in peripheral blood mononuclear cells of cynomolgus macaques during acute infection with SIVmac251 . Regulation IL10 TNF 9310124 454810 Exogenous and the monoclonal antibody to TNF-alpha did not *affect* [IL-10] production and constitutive NF-kappa B binding levels in HuT 78 cells . Regulation IL10 TNF 9551930 499073 *Regulation* of monocyte [IL-10] synthesis by endogenous IL-1 and : role of the p38 and p42/44 mitogen activated protein kinases . Regulation IL10 TNF 9679667 520858 Transgenic expression of cytokines in beta-cells of non-diabetes-prone mice and NOD mice has suggested pathogenic roles for IFN alpha , IFN gamma , IL-2 and [IL-10] in insulin dependent diabetes mellitus ( IDDM ) development , and protective *roles* for IL-4 , IL-6 and . Regulation IL10 TNF 9806041 544678 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL10 TNF 9927530 588647 We investigated the *role* of in the regulation of MHC class II antigens and cytokine mRNA expression of TNF , interferon-gamma (IFN) , IL-2 , IL-4 , and [IL-10] in cardiac allografts to elucidate its immunological mechanism . Regulation IL11 ALOX5 8722494 373691 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL11 IL1B 12760902 1119674 Intestinal SEMFs secreted [IL-11] in *response* to and TGF-beta1 . Regulation IL11 IL1B 12889600 1117208 To study TGF-beta , TNF-alpha and *regulation* of IL-6 and [IL-11] production in human MDA-MB-231 breast cancer cells , we established single cell clones stably expressing dominant negative ( DN ) forms of the mitogen activated protein kinases p38 ( p38/AF ) or ERK1 ( ERK1K71R ) . Regulation IL11 IL1B 14617515 1200662 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL11 IL1B 20668109 2322494 To identify IL11 expression in vivo at the maternal-placental interface in preeclampsia and control specimens and to evaluate the regulatory *effects* of tumor necrosis factor-a (TNF) and , cytokines elevated in preeclampsia , on [IL11] levels in first trimester decidual cells in vitro , placental sections were immunostained for IL11 . Regulation IL11 IL1R2 2969889 95574 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL11 IL6R 9110148 425013 with two mutated gp130 binding sites did not *affect* [IL-11] , CNTF , LIF or OM activities . Regulation IL11 STAT4 19001140 1991078 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL11 TLR7 17034424 1683252 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL11 TLR7 18312842 1879646 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL11 TLR7 20471186 2294418 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL11 TNF 15998775 1452732 Unexpectedly , did not *affect* [IL-11] levels . Regulation IL11 TNF 20668109 2322493 To identify IL11 expression in vivo at the maternal-placental interface in preeclampsia and control specimens and to evaluate the regulatory *effects* of and IL1B , cytokines elevated in preeclampsia , on [IL11] levels in first trimester decidual cells in vitro , placental sections were immunostained for IL11 . Regulation IL11 TNF 3486658 59979 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL11 TNF 3491252 65984 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL11 TNF 7986155 282352 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL11 TNF 9806041 544681 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL11 TNF 9811056 545532 Here , we characterized the combined *effect* of IL-1alpha and , major cytokines in the rheumatoid synovium , on the production of [IL-11] by cultured rheumatoid synovial fibroblasts ( RSFs ) . Regulation IL12A EPHB2 11781388 900343 These findings suggest that TNF-alpha induced activation negatively *controls* maturation and [IL-12] production in murine DC . Regulation IL12A EPHB2 11971021 933500 Studies using rIL-10 and IL-10 gene-deficient mice demonstrated that the inhibitory *effect* of on CpG DNA mediated [IL-12] production is indirect , due to the role of ERK in mediating IL-10 production . Regulation IL12A EPHB2 14556972 1153404 It seems that *roles* of and p38 MAPK for [IL-12] production are developmentally changed in murine DC . Regulation IL12A EPHB2 20511709 2270507 Both LPS and GA stimulated the production of IL-6 , IL-10 , [IL12p70] and TNFalpha in a p38- and/or *dependent* manner . Regulation IL12A EPHB2 24434636 2922587 While p38 and JNK did not seem to play a role in the modulation properties of S1P on cytokine production , is at least partially *involved* in the S1P mediated modulation of [IL-12] and IL-27 . Regulation IL12A IFI27 17702989 1788742 Thus , we hypothesized that is *involved* in elevated [IL-12] production from BWF1 BMDCs . Regulation IL12A IL1B 16499573 1528913 When infected HeLa cells were co-cultured with THP-1 cells , IL-6 and IL-8 secretion was sustained , expression followed a bell shaped curve and IL-10 , [IL-12p70] and TNF-alpha synthesis was down *regulated* . Regulation IL12A ITGB2 11009109 735884 is also *involved* in reduction of [IL-12] release by L. major infected macrophages , as uptake of opsonized parasites ( via CR3 ) decreased IL-12 release only in WT , but not in CD18-/- macrophages . Regulation IL12A JAG1 10861095 705282 [IL-12] is a proinflammatory cytokine secreted by dendritic cells in *response* to microbial and mitogens . Regulation IL12A JAG1 12055206 951705 Defective [IL-12] *responses* to T. gondii ( soluble tachyzoite Ag (STAg) ) were observed in MyD88 ( -/- ) peritoneal macrophages , neutrophils , and splenic dendritic cells ( DC ) . Regulation IL12A PTGER2 23337716 2753648 These results can be explained by differential *regulation* of the common subunit , [IL-12p40] , and IL-23p19 , by and EP(4) . Regulation IL12A SPHK1 21435724 2416929 To investigate the immune modulatory *role* of as opposed to SphK2 specifically for the Th1 propagating [IL-12p70] we compared WT and SphK1 ( -/- ) splenocytes and Flt3-ligand differentiated BMCs of WT and SphK1 ( -/- ) , representing dendritic cells as major producers of IL-12p70 , incubated with LPS . Regulation IL12A SPHK1 21435724 2416941 To further characterize *dependent* [IL-12p70] regulation we exogenously applied S1P , SEW2871 and the new potent S1P1 agonist CYM5442 . Regulation IL12A STAT4 11466347 839917 These results indicate that and IFN-gamma *play* an indispensable role and a role as an amplifying factor , respectively , in [IL-12] induction of the functional IL-18R complex . Regulation IL12A STAT4 11739505 886529 A mandatory *role* for in [IL-12] induction of mouse T cell CCR5 . Regulation IL12A STAT4 25073792 2953904 We report a crucial role for the transcriptional regulator Blimp-1 , induced by [IL-12] in a *dependent* manner , in controlling IL-10 expression in Th1 cells . Regulation IL12A STAT4 8700208 373002 To determine the function of and its *role* in [IL-12] signalling , we have produced mice that lack Stat4 by gene targeting . Regulation IL12A TLR7 15153515 1250103 Although we identify TLR2 as the receptor triggering CCL2 production , parasite induced [IL-12] release did not *involve* this . Regulation IL12A TLR7 15851485 1399496 Dendritic cells ( DC ) produce [interleukin-12 (IL-12)] in *response* to activation . Regulation IL12A TLR7 15851485 1399522 Moreover , analysis of interferon regulatory factors (IRF) regulation in moDC suggests a role for IRF7/8 in mediating IRF3 independent type I IFN and possibly [IL-12p35] synthesis in *response* to . Regulation IL12A TLR7 16009271 1431471 However , [IL-12p70] production in *response* to stimulating agents plus IFN-gamma was consistently lower in AIMV medium although also under serumfree culture conditions , nanogram quantities of IL-12 were produced . Regulation IL12A TLR7 17918201 1819420 In this study , we investigated which mouse B cell subsets are the most potent cytokine producers , and examined the *role* of in the control of secretion of IL-6 , IL-10 , [IL-12] and IFN-gamma by B cells . Regulation IL12A TLR7 17981792 1845626 [IL-12p40] was also produced by poly ( A : U ) -stimulated pDC in a *dependent* manner . Regulation IL12A TLR7 17981792 1845628 In addition to pDC , conventional dendritic cell ( cDC ) also produced IL-12p40 in response to poly ( A : U ) . This [IL-12p40] induction resulted from two cDC subsets , CD24 ( high ) cDC and CD11b ( high ) cDC in a TLR3- and *dependent* manner , respectively . Regulation IL12A TLR7 18209037 1857717 Exposure of bone marrow derived dendritic cells to E2 also enhanced production of [IL-12] in *response* to the ligands , CpG and LPS . Regulation IL12A TLR7 18461564 1916451 However , there was little induction of [IL-12] by either subset in *response* to ligation . Regulation IL12A TLR7 19322177 2064516 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and [IL-12p40] ( also known as IL12b ) , but not TNF , in *response* to ligands . Regulation IL12A TLR7 19637227 2143098 Neonatal myeloid DC were shown to be deficient in IFN-beta and [IL-12] synthesis in *response* to triggering . Regulation IL12A TLR7 19917677 2166700 In *response* to most ligands , neonatal innate immune cells , including monocytes and conventional and plasmacytoid dendritic cells produced less [IL-12p70] and IFN-alpha ( and consequently induced less IFN-gamma ) , moderately less TNF-alpha , but as much or even more IL-1beta , IL-6 , IL-23 , and IL-10 than adult cells . Regulation IL12A TLR7 19933865 2172075 Tpl2 ( -/- ) macrophages have abrogated TNF production but overproduce [IL-12] in *response* to ligands . Regulation IL12A TLR7 20408896 2300646 In the present study , we examined the effect of prostaglandin E ( 2 ) ( PGE ( 2 ) ) treatment of DCs during differentiation on [IL-12] and IL-23 production in *response* to stimulation . Regulation IL12A TLR7 20851125 2331481 Substitution of the acidic loop in TgPRF with the homologous loop from the apicomplexan parasite Cryptosporidium parvum does not affect *dependent* [IL-12] secretion , while substitution with the acidic loop from Plasmodium falciparum results in reduced but significant IL-12 secretion . Regulation IL12A TLR7 21097503 2383210 A deficiency in functional UNC93B1 protein abolished *dependent* [IL-12] secretion by dendritic cells , attenuated Th1 responses against T. gondii , and dramatically enhanced susceptibility to the parasite . Regulation IL12A TLR7 21106540 2389861 Mouse macrophages produce [IL-12] and IL-10 in *response* to ligands such as LPS , CpG , Poly I:C and Malp2 . Regulation IL12A TLR7 22536449 2590127 Here , we examine the *role* of and reactive oxygen species ( ROS ) in [IL-12] production by LAB stimulated peritoneal macrophages . Regulation IL12A TLR7 23246311 2732251 *dependent* induction of [IL-12] and IFN-a in pDCs led to production of IFN-? by NK cells . Regulation IL12A TLR7 23504259 2809818 Adenosine signaling suppresses the *dependent* expression of TNF-a , [IL-12] , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Regulation IL12A TLR7 23750720 2834123 In contrast to humans , pDC in rhesus macaques expressed the [interleukin (IL)-12p40] subunit in *response* to as well as TLR-9 stimulation . Regulation IL12A TLR7 23880957 2825526 The *effect* of proinflammatory cytokines [ tumor necrosis factor a (TNFa) and IL-17 ] and ligands [ poly ( I:C ) and lipopolysaccharide (LPS) ] on IL-17R expression and [IL-12] and IL-23 production was studied in osteoarthritis ( OA ) - and rheumatoid arthritis ( RA ) -FLS , involved in Th1/Th17 differentiation . Regulation IL12A TLR7 23967307 2832749 In this study , our data suggest that Tim-3 and [IL-12/IL-23] gene transcriptions are *regulated* by enhanced or silenced Gal-9 expression within monocytes through synergizing with signaling . Regulation IL12A TLR7 24078692 2857922 In this study , we establish that , in addition to , TLR12 recognizes the profilin protein of the protozoan parasite Toxoplasma gondii and *regulates* [IL-12] production by DCs in response to the parasite . Regulation IL12A TNF 11781388 900342 These findings suggest that induced ERK activation negatively *controls* maturation and [IL-12] production in murine DC . Regulation IL12A TNF 1373169 183258 Thus , [IL-12] can directly influence NK cell activities in purified CD56+ cells , and endogenously produced is *involved* in mediating the effects of both IL-12 and IL-7 . Regulation IL12A TNF 14670333 1188959 In an attempt to determine the *role* of IFN-gamma and in [IL-12] induced immunity , IFN-gamma and TNFR-p55 knockout mice were immunized with rSm14/IL-12 and no protection was achieved . Regulation IL12A TNF 15611045 1375322 The ERK signaling pathway is not involved in and nitric oxide production , but , interestingly , negatively *regulates* the expression of IL-6 and [IL-12] . Regulation IL12A TNF 16210605 1464424 TNFR1 was established as the main receptor involved in IL-12p40 regulation , because [IL-12p40] levels were not *affected* by in TNFR1 ( -/- ) -derived macrophages . Regulation IL12A TNF 17854477 1795904 These data indicate that CpG-ODN protects animals against lethal C. albicans challenge via a pathway that involves the *dependent* induction of [IL-12] . Regulation IL12A TNF 17893129 1823889 Cytokine analysis was performed on infected peritoneal macrophages isolated from these mice , and immunocompetent macrophages showed robust alpha , IFN-gamma , and granulocyte-macrophage colony stimulating factor ( GM-CSF ) but no [interleukin-12 (IL-12)] *responses* . Regulation IL12A TNF 21670312 2451211 Finally , there is a strong synergy between calcium depletion in the ER and sterile IL-6 , as well as LPS dependent IL-1ß , [IL-12] , IL-23 , and innate *responses* , findings that have implications for understanding inflammatory diseases that originate in the ER . Regulation IL12A TNF 22693231 2638691 Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß) , interleukin 6 (IL-6) , interleukin 10 (IL-10) , [interleukin 12 (IL-12)] , and *responses* to Toll-like receptor (TLR) 3 and TLR4 stimulation . Regulation IL12A TNF 8843212 387371 Earlier and stronger [interleukin (IL)-12] , interferon-gamma (IFN)-gamma , and *responses* were found in Borrelia burgdorferi infected , vitamin A-deficient mice compared with controls . Regulation IL12A TNF 9806041 544732 *Regulation* of [interleukin (IL)-12] production by coexpression of , IL-10 , and transforming growth factor (TGF)-beta in human monocytes infected with Mycobacterium tuberculosis H37Ra was analyzed . Regulation IL12A TNF 9916686 587479 Based on previous work that suggests that the production of [IL-12] by activated human central nervous system derived microglia is *regulated* by autocrine , we wanted to determine whether inhibition of TNF could induce a reduction of Th1 responses by its impact on systemic APCs . Regulation IL12B CD14 15516327 1328553 LPS induced increase of [IL-23] and IL-12 subunits expression was *dependent* , while CD14 was not involved in SAC induced p19 transcription . Regulation IL12B EPHB2 11781388 900345 These findings suggest that TNF-alpha induced activation negatively *controls* maturation and [IL-12] production in murine DC . Regulation IL12B EPHB2 11971021 933501 Studies using rIL-10 and IL-10 gene-deficient mice demonstrated that the inhibitory *effect* of on CpG DNA mediated [IL-12] production is indirect , due to the role of ERK in mediating IL-10 production . Regulation IL12B EPHB2 14556972 1153418 It seems that *roles* of and p38 MAPK for [IL-12] production are developmentally changed in murine DC . Regulation IL12B EPHB2 20511709 2270508 Both LPS and GA stimulated the production of IL-6 , IL-10 , [IL12p70] and TNFalpha in a p38- and/or *dependent* manner . Regulation IL12B EPHB2 24434636 2922588 While p38 and JNK did not seem to play a role in the modulation properties of S1P on cytokine production , is at least partially *involved* in the S1P mediated modulation of [IL-12] and IL-27 . Regulation IL12B IFI27 17702989 1788748 Thus , we hypothesized that is *involved* in elevated [IL-12] production from BWF1 BMDCs . Regulation IL12B IL1B 16499573 1528914 When infected HeLa cells were co-cultured with THP-1 cells , IL-6 and IL-8 secretion was sustained , expression followed a bell shaped curve and IL-10 , [IL-12p70] and TNF-alpha synthesis was down *regulated* . Regulation IL12B IL1B 17569750 1774222 To explore the source of the p19 subunit of interleukin-23 (IL-23) in joints with rheumatoid arthritis ( RA ) , the *effects* of and tumour necrosis factor (TNF)-alpha on [IL-23] gene expression in RA fibroblast-like synoviocytes and the effect of IL-23 on proinflammatory cytokines . Regulation IL12B ITGB2 11009109 735885 is also *involved* in reduction of [IL-12] release by L. major infected macrophages , as uptake of opsonized parasites ( via CR3 ) decreased IL-12 release only in WT , but not in CD18-/- macrophages . Regulation IL12B JAG1 10861095 705283 [IL-12] is a proinflammatory cytokine secreted by dendritic cells in *response* to microbial and mitogens . Regulation IL12B JAG1 12055206 951706 Defective [IL-12] *responses* to T. gondii ( soluble tachyzoite Ag (STAg) ) were observed in MyD88 ( -/- ) peritoneal macrophages , neutrophils , and splenic dendritic cells ( DC ) . Regulation IL12B NEDD9 22427889 2573181 The differential *effects* of on Ifnb and [Il12b] expression inversely correlated with the function of one of its binding partners , c-Rel . Regulation IL12B PTGER2 23337716 2753650 These results can be explained by differential *regulation* of the common subunit , [IL-12p40] , and IL-23p19 , by and EP(4) . Regulation IL12B RORC 23469228 2750331 Variable expression of CD161 , IL-23R and *affects* [IL-23] responsiveness and contributes to the inter-individual susceptibility to IL-23 mediated defenses and inflammatory processes . Regulation IL12B SPHK1 21435724 2416930 To investigate the immune modulatory *role* of as opposed to SphK2 specifically for the Th1 propagating [IL-12p70] we compared WT and SphK1 ( -/- ) splenocytes and Flt3-ligand differentiated BMCs of WT and SphK1 ( -/- ) , representing dendritic cells as major producers of IL-12p70 , incubated with LPS . Regulation IL12B SPHK1 21435724 2416942 To further characterize dependent [IL-12p70] *regulation* we exogenously applied S1P , SEW2871 and the new potent S1P1 agonist CYM5442 . Regulation IL12B STAT4 11466347 839919 These results indicate that and IFN-gamma *play* an indispensable role and a role as an amplifying factor , respectively , in [IL-12] induction of the functional IL-18R complex . Regulation IL12B STAT4 11739505 886530 A mandatory *role* for in [IL-12] induction of mouse T cell CCR5 . Regulation IL12B STAT4 25073792 2953905 We report a crucial role for the transcriptional regulator Blimp-1 , induced by [IL-12] in a *dependent* manner , in controlling IL-10 expression in Th1 cells . Regulation IL12B STAT4 8700208 373003 To determine the function of and its *role* in [IL-12] signalling , we have produced mice that lack Stat4 by gene targeting . Regulation IL12B TLR7 15153515 1250113 Although we identify TLR2 as the receptor triggering CCL2 production , parasite induced [IL-12] release did not *involve* this . Regulation IL12B TLR7 15851485 1399506 Dendritic cells ( DC ) produce [interleukin-12 (IL-12)] in *response* to activation . Regulation IL12B TLR7 15851485 1399524 Moreover , analysis of interferon regulatory factors (IRF) regulation in moDC suggests a role for IRF7/8 in mediating IRF3 independent type I IFN and possibly [IL-12p35] synthesis in *response* to . Regulation IL12B TLR7 16009271 1431481 However , [IL-12p70] production in *response* to stimulating agents plus IFN-gamma was consistently lower in AIMV medium although also under serumfree culture conditions , nanogram quantities of IL-12 were produced . Regulation IL12B TLR7 17897860 1811297 TLR3 and are *involved* in expression of [IL-23] subunits while TLR3 but not TLR7 is involved in expression of IFN-beta by Theiler 's virus infected RAW264.7 cells . Regulation IL12B TLR7 17918201 1819430 In this study , we investigated which mouse B cell subsets are the most potent cytokine producers , and examined the *role* of in the control of secretion of IL-6 , IL-10 , [IL-12] and IFN-gamma by B cells . Regulation IL12B TLR7 17981792 1845627 [IL-12p40] was also produced by poly ( A : U ) -stimulated pDC in a *dependent* manner . Regulation IL12B TLR7 17981792 1845629 In addition to pDC , conventional dendritic cell ( cDC ) also produced IL-12p40 in response to poly ( A : U ) . This [IL-12p40] induction resulted from two cDC subsets , CD24 ( high ) cDC and CD11b ( high ) cDC in a TLR3- and *dependent* manner , respectively . Regulation IL12B TLR7 18209037 1857727 Exposure of bone marrow derived dendritic cells to E2 also enhanced production of [IL-12] in *response* to the ligands , CpG and LPS . Regulation IL12B TLR7 18276743 2010228 *dependent* induction of p19 , p40 and bioactive [IL23] was determined in RA synovial fibroblasts ( RASF ) , monocytes and monocyte derived dendritic cells ( MDDCs ) by real-time PCR and reverse transcriptase ( RT ) -PCR , Western blot and functional assays . Regulation IL12B TLR7 18461564 1916461 However , there was little induction of [IL-12] by either subset in *response* to ligation . Regulation IL12B TLR7 18802116 1965000 Notably , [IL-23] production in *response* to single ligands was inhibited by IL-4 . Regulation IL12B TLR7 19322177 2064526 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and [IL-12p40] ( also known as IL12b ) , but not TNF , in *response* to ligands . Regulation IL12B TLR7 19637227 2143108 Neonatal myeloid DC were shown to be deficient in IFN-beta and [IL-12] synthesis in *response* to triggering . Regulation IL12B TLR7 19917677 2166710 In *response* to most ligands , neonatal innate immune cells , including monocytes and conventional and plasmacytoid dendritic cells produced less [IL-12p70] and IFN-alpha ( and consequently induced less IFN-gamma ) , moderately less TNF-alpha , but as much or even more IL-1beta , IL-6 , IL-23 , and IL-10 than adult cells . Regulation IL12B TLR7 19933865 2172085 Tpl2 ( -/- ) macrophages have abrogated TNF production but overproduce [IL-12] in *response* to ligands . Regulation IL12B TLR7 20408896 2300656 In the present study , we examined the effect of prostaglandin E ( 2 ) ( PGE ( 2 ) ) treatment of DCs during differentiation on [IL-12] and IL-23 production in *response* to stimulation . Regulation IL12B TLR7 20483758 2270105 Human intestinal lamina propria CD1c+ dendritic cells display an activated phenotype at steady state and produce [IL-23] in *response* to stimulation . Regulation IL12B TLR7 20851125 2331491 Substitution of the acidic loop in TgPRF with the homologous loop from the apicomplexan parasite Cryptosporidium parvum does not affect *dependent* [IL-12] secretion , while substitution with the acidic loop from Plasmodium falciparum results in reduced but significant IL-12 secretion . Regulation IL12B TLR7 21097503 2383220 A deficiency in functional UNC93B1 protein abolished *dependent* [IL-12] secretion by dendritic cells , attenuated Th1 responses against T. gondii , and dramatically enhanced susceptibility to the parasite . Regulation IL12B TLR7 21106540 2389871 Mouse macrophages produce [IL-12] and IL-10 in *response* to ligands such as LPS , CpG , Poly I:C and Malp2 . Regulation IL12B TLR7 22536449 2590137 Here , we examine the *role* of and reactive oxygen species ( ROS ) in [IL-12] production by LAB stimulated peritoneal macrophages . Regulation IL12B TLR7 23246311 2732261 *dependent* induction of [IL-12] and IFN-a in pDCs led to production of IFN-? by NK cells . Regulation IL12B TLR7 23504259 2809828 Adenosine signaling suppresses the *dependent* expression of TNF-a , [IL-12] , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Regulation IL12B TLR7 23750720 2834126 In contrast to humans , pDC in rhesus macaques expressed the [interleukin (IL)-12p40] subunit in *response* to as well as TLR-9 stimulation . Regulation IL12B TLR7 23880957 2825536 The *effect* of proinflammatory cytokines [ tumor necrosis factor a (TNFa) and IL-17 ] and ligands [ poly ( I:C ) and lipopolysaccharide (LPS) ] on IL-17R expression and IL-12 and [IL-23] production was studied in osteoarthritis ( OA ) - and rheumatoid arthritis ( RA ) -FLS , involved in Th1/Th17 differentiation . Regulation IL12B TLR7 23967307 2832760 In this study , our data suggest that Tim-3 and [IL-12/IL-23] gene transcriptions are *regulated* by enhanced or silenced Gal-9 expression within monocytes through synergizing with signaling . Regulation IL12B TLR7 24078692 2857932 In this study , we establish that , in addition to TLR11 , recognizes the profilin protein of the protozoan parasite Toxoplasma gondii and *regulates* [IL-12] production by DCs in response to the parasite . Regulation IL12B TNF 11781388 900344 These findings suggest that induced ERK activation negatively *controls* maturation and [IL-12] production in murine DC . Regulation IL12B TNF 1373169 183259 Thus , [IL-12] can directly influence NK cell activities in purified CD56+ cells , and endogenously produced is *involved* in mediating the effects of both IL-12 and IL-7 . Regulation IL12B TNF 14670333 1188961 In an attempt to determine the *role* of IFN-gamma and in [IL-12] induced immunity , IFN-gamma and TNFR-p55 knockout mice were immunized with rSm14/IL-12 and no protection was achieved . Regulation IL12B TNF 15611045 1375323 The ERK signaling pathway is not involved in and nitric oxide production , but , interestingly , negatively *regulates* the expression of IL-6 and [IL-12] . Regulation IL12B TNF 16210605 1464425 TNFR1 was established as the main receptor involved in IL-12p40 regulation , because [IL-12p40] levels were not *affected* by in TNFR1 ( -/- ) -derived macrophages . Regulation IL12B TNF 17569750 1774221 To explore the source of the p19 subunit of interleukin-23 (IL-23) in joints with rheumatoid arthritis ( RA ) , the *effects* of IL-1beta and on [IL-23] gene expression in RA fibroblast-like synoviocytes and the effect of IL-23 on proinflammatory cytokines . Regulation IL12B TNF 17854477 1795905 These data indicate that CpG-ODN protects animals against lethal C. albicans challenge via a pathway that involves the *dependent* induction of [IL-12] . Regulation IL12B TNF 17893129 1823891 Cytokine analysis was performed on infected peritoneal macrophages isolated from these mice , and immunocompetent macrophages showed robust alpha , IFN-gamma , and granulocyte-macrophage colony stimulating factor ( GM-CSF ) but no [interleukin-12 (IL-12)] *responses* . Regulation IL12B TNF 21670312 2451212 Finally , there is a strong synergy between calcium depletion in the ER and sterile IL-6 , as well as LPS dependent IL-1ß , [IL-12] , IL-23 , and innate *responses* , findings that have implications for understanding inflammatory diseases that originate in the ER . Regulation IL12B TNF 22693231 2638694 Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß) , interleukin 6 (IL-6) , interleukin 10 (IL-10) , [interleukin 12 (IL-12)] , and *responses* to Toll-like receptor (TLR) 3 and TLR4 stimulation . Regulation IL12B TNF 8843212 387372 Earlier and stronger [interleukin (IL)-12] , interferon-gamma (IFN)-gamma , and *responses* were found in Borrelia burgdorferi infected , vitamin A-deficient mice compared with controls . Regulation IL12B TNF 9806041 544737 *Regulation* of [interleukin (IL)-12] production by coexpression of , IL-10 , and transforming growth factor (TGF)-beta in human monocytes infected with Mycobacterium tuberculosis H37Ra was analyzed . Regulation IL12B TNF 9916686 587480 Based on previous work that suggests that the production of [IL-12] by activated human central nervous system derived microglia is *regulated* by autocrine , we wanted to determine whether inhibition of TNF could induce a reduction of Th1 responses by its impact on systemic APCs . Regulation IL13 ALOX5 8722494 373692 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL13 ARSA 11238116 790479 In contrast , did not *affect* [IL-13] , interferon-gamma , and IL-2 expression . Regulation IL13 EPHB2 11880312 919371 [IL-13] and IL-4 cause eotaxin release in human airway smooth muscle cells : a *role* for . Regulation IL13 IL1B 14617515 1200663 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL13 IL1B 15191916 1280933 Molecular *regulation* of [interleukin-13] and monocyte chemoattractant protein-1 expression in human mast cells by . Regulation IL13 IL1R2 2969889 95576 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL13 STAT4 19001140 1991079 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL13 TLR7 17034424 1683262 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL13 TLR7 18312842 1879656 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL13 TLR7 20471186 2294428 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL13 TNF 3486658 59980 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL13 TNF 3491252 65985 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL13 TNF 7986155 282353 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL13 TNF 9806041 544684 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL15 ALOX5 8722494 373693 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL15 IL1B 14617515 1200664 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL15 IL1B 14967219 1209133 In the present study , we evaluated the *effects* of , a proinflammatory cytokine , on [IL-15] production in ESCs . Regulation IL15 IL1B 14967219 1209137 These results suggest that ovarian steroid hormones and *regulate* [IL-15] mRNA expression and protein production in long-term culture , and that IL-1beta plays a role as a negative regulator of IL-15 production during decidualization in human endometrium . Regulation IL15 IL1R2 2969889 95578 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL15 STAT4 19001140 1991080 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL15 TLR7 17034424 1683272 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL15 TLR7 18312842 1879666 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL15 TLR7 20471186 2294438 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL15 TNF 16507118 1645618 In this study we investigated the *effect* of blockade ( infliximab ) on the synovial expression of [IL-15] in RA in relation to different cell types and expression of other cytokines , to elucidate whether or not IL-15 is a possible target for therapy , independently of TNF blockade . Regulation IL15 TNF 21794570 2185293 Our data seem to support previous in vitro findings suggesting that is *involved* in the regulation of [IL-15] expression . Regulation IL15 TNF 3486658 59981 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL15 TNF 3491252 65986 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL15 TNF 7986155 282354 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL15 TNF 9806041 544687 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL16 ALOX5 8722494 373694 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL16 IL1B 14617515 1200665 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL16 IL1R2 2969889 95580 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL16 STAT4 19001140 1991081 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL16 TLR7 17034424 1683282 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL16 TLR7 18312842 1879676 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL16 TLR7 20471186 2294448 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL16 TNF 3486658 59982 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL16 TNF 3491252 65987 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL16 TNF 7986155 282355 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL16 TNF 9806041 544690 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL17A EPHB2 15982617 1424797 We also found that p38MAPK , JNK , p42/p44 and NF-kappaB *play* an important role in [IL-17] -- induced IL-8 production in HASMC in vitro . Regulation IL17A EPHB2 20299682 2293744 The MAPK , known to mediate transcription of IL-1beta mRNA , was strongly *involved* in the [IL-17A] production induced by MTB . Regulation IL17A IL1B 19666510 2125978 Similarly , Th17 cells produce [IL-17A] in *response* to and a STAT3 activator and Th1 cells produce IFNgamma in response to IL-18 and a STAT4 inducer . Regulation IL17A IL1B 19682929 2126277 Here , we show that gammadelta T cells express IL-23R and the transcription factor RORgammat and produce [IL-17] , IL-21 , and IL-22 in *response* to and IL-23 , without T cell receptor engagement . Regulation IL17A IL1B 19740775 2163270 IL23 and plus IL6 had no *effect* on IBD LPMC production of [IL17] ; Regulation IL17A ITGB2 12734371 1087326 Our data suggest regulatory *effects* of on G-CSF and [IL-17] secretion , and as a corollary on neutrophilia . Regulation IL17A JAG1 20083670 2206016 Splenocytes isolated from mice infected by the transurethral route robustly expressed [IL-17A] in *response* to in vitro stimulation with uropathogenic E. coli . Regulation IL17A JAG1 21490151 2422915 In this article , we demonstrate that LT acts as a highly effective adjuvant when administered parenterally , promoting Ag-specific [IL-17] , as well as IFN-? , IL-4 , and IL-10 production in *response* to coadministered . Regulation IL17A JAG1 21918192 2491976 tumor rejection requires [IL-17] , which is produced by IFN-?-deficient CD4 ( + ) T cells in *response* to tumor ( TAs ) . Regulation IL17A RORC 19578368 2111600 Downregulation of either the aryl hydrocarbon receptor (AHR) or the transcription factor RORC by RNA mediated interference affected IL-22 production , whereas [IL-17] production was *affected* only by downregulation of by RNA mediated interference . Regulation IL17A RORC 20200272 2229575 Furthermore , we demonstrated in vitro that mast cells produced *dependent* [IL-17A] upon stimulation with TNF-alpha , IgG complexes , C5a , and LPS . Regulation IL17A STAT4 23001997 2702214 Consistent with the idea that *regulates* the production of [interleukin-17 (IL-17)] and interferon-? , IL17 messenger RNA and protein levels were increased in individuals carrying the rs897200 risk genotype AA . Regulation IL17A TLR7 23880957 2825546 The *effect* of proinflammatory cytokines [ tumor necrosis factor a (TNFa) and IL-17 ] and ligands [ poly ( I:C ) and lipopolysaccharide (LPS) ] on [IL-17R] expression and IL-12 and IL-23 production was studied in osteoarthritis ( OA ) - and rheumatoid arthritis ( RA ) -FLS , involved in Th1/Th17 differentiation . Regulation IL17A TNF 11012616 736106 We therefore investigated the in vitro IL-17 response to a variety of mitogens and antigens , and compared the [IL-17] *response* to interferon-gamma (IFN-gamma) , IL-4 , IL-10 and . Regulation IL17A TNF 20345974 2287659 Ingestion of faecal slurry resulted in a transient , early onset of proinflammatory interferon (IFN)-gamma , and [interleukin (IL)-17] *response* that was maximal at day 3 . Regulation IL17A TNF 21084465 2371767 Increased pulmonary alpha , interleukin-6 (IL-6) , and [IL-17A] *responses* compensate for decreased gamma interferon production in anti-IL-12 autovaccine treated , Mycobacterium bovis BCG vaccinated mice . Regulation IL17A TNF 21402950 2411943 from inflammatory dendritic cells (DCs) *regulates* lung [IL-17A/IL-5] levels and neutrophilia versus eosinophilia during persistent fungal infection . Regulation IL17D EPHB2 24434636 2922589 While p38 and JNK did not seem to play a role in the modulation properties of S1P on cytokine production , is at least partially *involved* in the S1P mediated modulation of IL-12 and [IL-27] . Regulation IL17D TLR7 17684041 1805582 We report that *dependent* expression of [IL-27] in human macrophages is mediated by IFN-alpha . Regulation IL17RC TNF 23648353 2779700 [ *Effect* of on expression of [interleukin-17 receptor C] in pulmonary microvascular endothelial cells in rats ] . Regulation IL17RC TNF 23648353 2779701 To explore the *effects* of ( TNF-a ) or methylprednisolone on the expression of [interleukin-17 receptor C (IL-17RC)] in rat pulmonary microvascular endothelial cells ( RPMVEC ) . Regulation IL17RD EPHB2 21663947 2459821 We found that the [hSef] expression was positively *regulated* by FGF2 induced signaling and inversely , hSef expression efficiently inhibited the activity of FGF2 induced MAPK/ERK signaling , indicating the presence of hSef mediated negative feedback mechanism for FGF signaling in endometrial cancer cells . Regulation IL18 ALOX5 8722494 373695 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL18 CD14 11097749 755798 LPS mediated [IL-18] gene expression and secretion was *dependent* and significantly inhibited by co-incubation of PBMC with neutralizing CD14 antibody ( P < 0.01 ) . Regulation IL18 FAS 17021654 1765511 Both mitomycin C and cisplatin induced apoptosis in C-33A cells via caspase-8 and -3 processing in a *dependent* manner and also suppressed [IL-18] expression , while they down-regulated IkappaB expression and up-regulated p65 expression . Regulation IL18 IL1B 11022122 737968 Finally , our results show that stimulation of the keratinocyte cell line HaCaT with PMA LPS or , does not significantly *affect* intracellular or released ( pro ) [IL-18] levels . Regulation IL18 IL1B 14617515 1200666 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL18 IL1R2 2969889 95582 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL18 MMP28 16554298 1562005 Because we demonstrated previously that the proinflammatory and proatherogenic cytokine interleukin-18 (IL-18) stimulates SMC proliferation ( Chandrasekar , B. , Mummidi , S. , Valente , A. J. , Patel , D. N. , Bailey , S. R. , Freeman , G. L. , Hatano , M. , Tokuhisa , T. , and Jensen , L. E. ( 2005 ) J. Biol. Chem. 280 , 26263-26277 ) , we investigated whether [IL-18] induces SMC migration in an *dependent* manner and whether the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin can inhibit this response . Regulation IL18 MMP7 16554298 1562020 Because we demonstrated previously that the proinflammatory and proatherogenic cytokine interleukin-18 (IL-18) stimulates SMC proliferation ( Chandrasekar , B. , Mummidi , S. , Valente , A. J. , Patel , D. N. , Bailey , S. R. , Freeman , G. L. , Hatano , M. , Tokuhisa , T. , and Jensen , L. E. ( 2005 ) J. Biol. Chem. 280 , 26263-26277 ) , we investigated whether [IL-18] induces SMC migration in an *dependent* manner and whether the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin can inhibit this response . Regulation IL18 STAT4 11466347 839921 These results indicate that and IFN-gamma *play* an indispensable role and a role as an amplifying factor , respectively , in IL-12 induction of the functional [IL-18R] complex . Regulation IL18 STAT4 19001140 1991082 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL18 TF 18835036 2012814 In conclusion , *regulates* [IL-18] expression and we suggest that it is involved in cytokine production . Regulation IL18 TLR7 17034424 1683292 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL18 TLR7 18312842 1879686 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL18 TLR7 20471186 2294458 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL18 TNF 12804640 1101466 Additionally , we also found the effective modulating *effect* of M-CSF , IFN-alpha and on [IL-18R] expression , implying an important in vivo effect of cytokines on IL-18 induced reaction . Regulation IL18 TNF 15894108 1407801 Tissue culture model of renal epithelial cells expressed IL-18 mRNA constitutively and released mature [IL-18] in *response* to and IFN-gamma . Regulation IL18 TNF 16464907 1567560 We investigated the *effects* of and IL-6 on [IL-18] gene expression in skeletal muscle and adipose tissue . Regulation IL18 TNF 16502344 1496235 Both cell lines upregulated IL-18R mRNA and [IL-18R] membrane expression in *response* to and other proinflammatory cytokines . Regulation IL18 TNF 3486658 59983 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL18 TNF 3491252 65988 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL18 TNF 7986155 282356 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL18 TNF 9806041 544693 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL19 ALOX5 8722494 373696 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL19 IL1B 14617515 1200667 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL19 IL1R2 2969889 95584 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL19 STAT4 19001140 1991083 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL19 TLR7 17034424 1683302 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL19 TLR7 18312842 1879696 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL19 TLR7 20471186 2294468 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL19 TNF 3486658 59984 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL19 TNF 3491252 65989 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL19 TNF 7986155 282357 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL19 TNF 9806041 544696 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL1A ALOX5 8722494 373707 It was , therefore , decided to investigate the *effects* of some <5-lipoxygenase> inhibitors compared with standard IL-1 synthesis inhibitors on the production of [IL-1] by human synovial tissue explants in organ culture . Regulation IL1A ALOX5 8722494 373710 Leukotriene B4 ( 1-100 ng/mL-1 ) added to MK-886 ( 5 microM ) -treated cultures reversed the inhibitory effects of the latter on IL-1 , confirming the *role* of <5-lipoxygenase> products in the regulation of [IL-1] production . Regulation IL1A ANGPT1 24563688 2919354 The *effects* of extended to the proteins , as Ang1 increased intracellular levels of precursor and mature [IL-1ß] , and extracellular levels of IL-1RA proteins , by up to 4.2- , 5.0- and 4.4-fold respectively , compared to PBS-control . Regulation IL1A ARSA 11133489 769140 Here , we examined the *effect* of on the [interleukin (IL)-1] beta- and tumor necrosis factor (TNF)-alpha induced proinflammatory cytokine expression and evaluated whether this effect is closely linked to the nuclear factor (NF)-kappa B/I kappa B-alpha pathway . Regulation IL1A CAPN8 18498295 1928053 Complex *effects* of IL1A polymorphism and inhibitors on [interleukin 1 alpha (IL-1 alpha)] mRNA levels and secretion of IL-1 alpha protein . Regulation IL1A CTGF 24464580 2923248 Interestingly , the suppressive *effect* of on [IL-1ß] was independent of modulation of NF-?B signaling . Regulation IL1A EPHB2 12654926 1092229 Inhibition of Erk in transgenic keratinocytes reduced basal IL-1alpha levels and the stimulation of IL-1alpha production by serum or phorbol ester , demonstrating that could *regulate* [IL-1alpha] expression . Regulation IL1A FAS 23144495 2707414 However , the mechanisms by which *regulates* [IL-1ß] activation remain unresolved . Regulation IL1A IL1B 12193539 981333 Cyclooxygenase 2 pathway mediates *regulation* of [IL-1alpha] , -1beta , and IL-6 mRNA levels in Leydig cell progenitors . Regulation IL1A IL1B 12759568 1030662 Next , we investigated the *effect* of LPS and on [IL-1] receptors . Regulation IL1A IL1B 1648453 160560 Furthermore , the combination of ADX and splenic nerve section resulted in a potent stimulatory *effect* of ICV on splenic macrophage [IL-1] secretion which was greater than either ADX or splenic nerve section alone . Regulation IL1A IL1B 1715791 165018 In this study , we investigated the *role* of in the malignant evolution of chronic myelogenous leukemia ( CML ) and the functional activity of [IL-1] inhibitors . Regulation IL1A IL1B 20034811 2205174 Therefore , we investigated the *effect* of high glucose and on the [IL-1RI] regulation in retinal endothelial cells . Regulation IL1A IL1B 22572995 2638067 Collectively , the results indicated that *regulates* expression of IL1R1 and [IL1RAP] and stimulates expression of PTGS1 and PTGS2 that are considered to be the most rate limiting enzymes for endometrial synthesis of PGs during the peri-implantation period of pregnancy in pigs . Regulation IL1A IL1B 2785413 111501 Sandwich enzyme immunoassay for IL-1 alpha or IL-1 beta revealed that was *responsible* for [IL-1] activity of these culture supernatants . Regulation IL1A IL1B 8243265 236515 We conclude that 1 ) [IL-1] receptors are involved in the ACTH and IL-6 *responses* to rat ; Regulation IL1A IL1B 8886022 391098 The fine regulation of the CNS IL-1 beta system may depend on a balance between the ligand ( ) *action* on the [IL-1RI] and the induction of inhibitory mechanisms ( IL-1RII and IL-1Ra ) . Regulation IL1A IL1R2 23999049 2851286 Importantly , the stimulatory effect of rgcIL-1ß on its own mRNA expression was blocked by rgcIL-1R2 in a dose dependent manner in grass carp HKLs , providing the evidence for a functional *role* of in [IL-1ß] signaling in teleost . Regulation IL1A MAP2K6 21308746 2398620 These results suggest that the p38a , MAPK , and *play* prominent roles in [IL-1ß] and C/EBP-ß mediated C3 gene expression in astrocytes . Regulation IL1A TGM2 24265865 2869852 All together , OPG and Tgase-2 is induced by [IL-1ß] or TPA in MG-63 cells and is *involved* in OPG expression in MG-63 cells . Regulation IL1A TLR7 21628463 2459314 Human myeloid cells activate the NLRP3 inflammasome and secrete [interleukin (IL)-1ß] in *response* to various ligands , but the rate of secretion is much higher in primary human monocytes than in cultured macrophages or THP-1 cells . Regulation IL1A TLR7 21968712 2617067 In this report , we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages , leading to incapability for the production of inflammatory cytokines like tumor necrosis factor (TNF)-a and [interleukin (IL)-1ß] in *response* to stimulation . Regulation IL1A TLR7 24126516 2889253 [IL-1ß] synthesis , maturation , and secretion are tightly *regulated* by signaling and inflammasome activation . Regulation IL1A TNF 10362047 619825 Monocyte chemotactic factors released from type II pneumocyte-like cells in *response* to and [IL-1alpha] . Regulation IL1A TNF 10643716 660984 In *response* to stimulation , messenger RNA ( mRNA ) levels for the IL-1 receptor I (IL-1RI) , [IL-1RII] , TNF receptor II (TNFR II) , and IL-6 receptor as well as the level of proinflammatory cytokines , such as IL-1alpha , IL-1beta , lymphotoxin beta , TNFalpha , and IL-6 , also increased . Regulation IL1A TNF 11027208 738603 The 5 ' NF-kB high-affinity binding site and AP-1 element contribute most to the enhancement of gene transcription in *response* to and [IL-1] . Regulation IL1A TNF 11028547 739579 SP-A inhibited the lipopolysaccharide (LPS) induced response of both interstitial and alveolar human Mphi , as well as the [IL-1] *response* in iMphi . Regulation IL1A TNF 15036245 1223861 We compared the production of [IL-1alpha] , IL-1beta , and of IL-1Ra isoforms by cultured human dermal ( HDF ) and synovial fibroblasts ( HSF ) in *response* to IL-1alpha , , or direct T cell membrane contact . Regulation IL1A TNF 15162534 1253060 Time course studies revealed an increased production of TNF-alpha preceding the IL-1 production , suggesting that increased levels could be *involved* in the increase of [IL-1] production . Regulation IL1A TNF 15379215 1298204 Time course studies revealed an increased production of TNF-a preceding the IL-1 production , suggesting that increased levels could be *involved* in the increased [IL-1] production . Regulation IL1A TNF 1774433 175460 These results suggest that plays a major role in the pathogenesis of galactosamine/LPS hepatitis in mice and that [IL-1 alpha] *acts* synergistically with TNF in this hepatitis model . Regulation IL1A TNF 1906383 161701 *Effects* of granulocyte-macrophage colony stimulating factor ( GM-CSF ) , IL-2 , interferon-gamma (IFN-gamma) , and IL-6 on the production of immunoreactive [IL-1] and TNF-alpha by human monocytes . Regulation IL1A TNF 1906383 161709 The *effects* of GM-CSF , IL-2 , IFN-gamma , and IL-6 on the production of [IL-1] ( both secreted and cell associated ) and TNF-alpha by peripheral blood monocytes were studied . Regulation IL1A TNF 19435506 2106938 Quantitative real-time polymerase chain reaction was used to assess the *effect* of or IL-beta stimulation on the expression of matrix metalloproteinase (MMP)-3 , -9 and -13 , TNF-alpha , TNF receptor 1 (TNF-R1) , TNF receptor 2 (TNF-R2) , [IL-1alpha] , IL-1beta , IL-1 receptor 1 (IL-1R1) and IL-1 receptor antagonist (IL-1Ra) . Regulation IL1A TNF 20078866 2218692 Inhibitions of IAPs , [IL-1alpha] and TNFalpha might be a possible target for PC treatment since IAPs are the proteins that inhibited apoptosis ( favour proliferation ) and IL-1alpha and would *affect* all the transduction pathway involucrate in the activation of transcription factors related to survival or proliferation ( NF-kB , Elk-1 or ATF-2 ) . Regulation IL1A TNF 20646344 2292586 In the current study , we report the divergent effects of two biological based RA therapies which target function ( infliximab ) or [IL1] *response* ( anakinra ) on the development of the NOS2 positive phenotype by PBDM in patients with refractory RA . Regulation IL1A TNF 2069802 162594 E. coli , GBS and had no significant *effect* on the production of [IL-1] . Regulation IL1A TNF 2112081 132995 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant interleukin-1 , , and gamma interferon on fibroblast proliferation , collagen production , [interleukin-1-alpha] production , interleukin-1-beta production , and interleukin-6 production . Regulation IL1A TNF 2156928 129522 Two human hepatoma cell lines ( SK-Hep and Hep-G2 ) displayed a time- and dose dependent increase in steady state levels of NCF/IL-8 mRNA and secretion of chemotactic activity in *response* to and [IL-1] . Regulation IL1A TNF 2248767 145985 Using an in vitro model , we report the early *effect* of Escherichia coli ( E. coli ) , Streptococcus agalactiea ( group B streptococci , GBS ) and recombinant on the release of lactoferrin (LF) and the generation of [interleukin-1 (IL-1)] due to E. coli , using heparinized whole blood from healthy full-term newborns . Regulation IL1A TNF 22693231 2638697 Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure [interleukin 1ß (IL-1ß)] , interleukin 6 (IL-6) , interleukin 10 (IL-10) , interleukin 12 (IL-12) , and *responses* to Toll-like receptor (TLR) 3 and TLR4 stimulation . Regulation IL1A TNF 22819042 2634990 Unlike normal cells , MCs expressing mutant Nlrp3 produced [IL-1ß] in *response* to lipopolysaccharide or . Regulation IL1A TNF 23445729 2749242 We also found that high-dose IgG specifically and completely inhibited accelerated expression of KD-related cytokines such as G-CSF , IL-6 and [IL-1ß] by HCAEC in *response* to . Regulation IL1A TNF 2370931 138360 We have investigated the *effect* of recombinant ( r-TNF ) on the release of [interleukin-1 (IL-1)] in glomerular cultures from rats with an accelerated autologous form of nephrotoxic serum nephritis ( NTSN ) . Regulation IL1A TNF 3261295 96027 This suggests that PAF is synthesized by the same pathway in *response* to or [IL-1] . Regulation IL1A TNF 3491252 66000 We investigated the *effect* of on [interleukin-1 (IL-1)] production by mouse macrophages . Regulation IL1A TNF 3494060 72243 FS-4 cells did not secrete soluble [IL 1] in *response* to . Regulation IL1A TNF 7693807 234230 Furthermore , although , preincubation of bEND.3 cells with IFN-gamma modestly increases the induction of ICAM-1 and VCAM-1 in *response* to and [IL-1] , it dramatically reduces the TNF-alpha , IL-1 , and LPS induced expression of MAdCAM-1 . Regulation IL1A TNF 8325511 223343 Northern blot analysis reveals a single 1.7-kb mRNA species that is differentially regulated by lipopolysaccharide , phorbol myristate acetate , and but is not *regulated* by human recombinant [IL-1] . Regulation IL1A TNF 8334682 223770 To determine whether *played* a role in the stimulation of [IL-1] production by L-MTP-PE , normal human monocytes were incubated with L-MTP-PE or medium in the presence or absence of anti-TNF or anti IL-1 alpha plus anti IL-1 beta . Regulation IL1A TNF 8387093 217936 In cells of the fibroblastoid line SV-80 , rapid down-modulation of TNF binding in *response* to itself , or to [IL-1] , was followed by a gradual recovery of binding , which occurred even in the continuous presence of the cytokines . Regulation IL1A TNF 8889469 391653 Differential *regulation* of [IL-1] and IL-1 receptor antagonist in HaCaT keratinocytes by and transforming growth factor-beta 1 . Regulation IL1A TNF 8928945 338222 The induction of IL-1 , [IL-1] inhibitory activity IL-6 , WBC , and total protein concentration responses are largely *independent* of activity in synovial fluid of horses receiving endotoxin intra-articularly . Regulation IL1A TNF 8952702 400968 These data suggest a potential *involvement* of endogenous in [IL-1] induced cytostasis and nitric oxide production . Regulation IL1A TNF 9488415 488731 Despite this defect , both mutant mouse strains had a rather normal proinflammatory cytokine response ( interleukin-12 [ IL-12 ] , IFN-gamma , IL-6 ) , with the exception of an impaired alpha and [IL-1alpha] *response* in IFN-gammaR ( -/- ) mice , demonstrating that only the latter two cytokines are dependent on IFN-gamma activation . Regulation IL1B ABCA1 9376570 465504 We thus investigated the *involvement* of in [IL-1beta] secretion , through the analysis of the effects of drugs known to inhibit IL-1beta secretion , on the activity of ABC1 and in turn the ability of known inhibitors of ABC1 of blocking IL-1beta secretion . Regulation IL1B ACD 9386984 466444 These findings suggest that systemic TNF alpha or [IL-1 beta] are not involved in the erythropoietin *response* to . Regulation IL1B ADM 12460645 1021911 The *effect* of aerosolized on [interleukin-1 beta] and transforming growth factor (TGF)-beta1 mRNA and protein expression was studied in surfactant depleted piglets , receiving aerosolized adrenomedullin ( adrenomedullin , n=6 ) , aerosolized adrenomedullin plus i.v . Regulation IL1B AGTR1 9262354 449106 The *effect* of central blockade on [interleukin-1beta-] and prostaglandin E-induced fevers in rats : possible involvement of brain angiotensin II receptor in fever induction . Regulation IL1B AGTR2 17884764 1797366 receptors are *involved* in alpha-TNF and [IL1 beta] secretions in cardiac fibroblasts . Regulation IL1B AGTR2 9262354 449107 The *effect* of central blockade on [interleukin-1beta-] and prostaglandin E-induced fevers in rats : possible involvement of brain angiotensin II receptor in fever induction . Regulation IL1B AHR 14725856 1198187 Nuclear run-on experiments were performed in SCC-12 cells to determine if the *dependent* increases in [IL-1beta] expression were due to transcriptional activation of the IL-1beta gene . Regulation IL1B AHR 14725856 1198188 Taken together , these results demonstrate that mediated [IL-1beta] *regulation* is occurring posttranscriptionally . Regulation IL1B AHR 15019843 1221015 We have previously shown that TCDD stimulated *dependent* [IL-1beta] expression in human keratinocytes is due to posttranscriptional regulation involving mRNA stabilization . Regulation IL1B AHSA1 17395477 1728143 In the present study the quantitative *role* of p42/44 and in the production of TNF-alpha , [IL-1beta] and IL-12 by murine peritoneal macrophages , in vitro , on treatment with Concanavalin A ( ConA ) has been investigated . Regulation IL1B AKT1 17504920 1744642 *Participation* of phosphatidyl inositol <3-kinase/protein kinase B> and ERK1/2 pathways in [interleukin-1beta] stimulation of lactate production in Sertoli cells . Regulation IL1B AKT1 19473116 2107551 We provide evidence that the *effect* of on [IL-1beta] activation is mediated by the inhibition of GSK3beta ( glycogen synthase kinase 3beta ) . Regulation IL1B AKT2 19473116 2107552 We provide evidence that the *effect* of on [IL-1beta] activation is mediated by the inhibition of GSK3beta ( glycogen synthase kinase 3beta ) . Regulation IL1B AKT3 19473116 2107553 We provide evidence that the *effect* of on [IL-1beta] activation is mediated by the inhibition of GSK3beta ( glycogen synthase kinase 3beta ) . Regulation IL1B ALB 16450750 1521995 To investigate the *effect* of AGE modified 132m and AGE-human on TNF-alpha and [IL-1beta] secretion by human peritoneal macrophages derived from patients on continuous ambulatory peritoneal dialysis . Regulation IL1B ANGPT1 15126358 1244844 These results suggest that [IL-1beta] indirectly *regulates* angiogenesis by modulating the expression of . Regulation IL1B APOA1 12458630 1021611 By themselves , apoA-I and apoA-II do not affect the basal liberation of these cytokines , whereas *affects* the release of [IL-1beta] from lipopolysaccharide (LPS) stimulated neutrophils and apoA-II affects IL-8 released from LPS stimulated neutrophils . Regulation IL1B APOB 1558837 184571 The maximal *effect* of oxidized on T-cell activation and [interleukin-1 beta] release occurred at a concentration of 1 micrograms/ml. Native LDL also had the capacity to activate T cells , although only at higher concentrations . Regulation IL1B APOE 15750212 1379854 This study investigated isoform-specific *effects* of on the regulation of PGE2 , COX2 , and [IL-1beta] expression . Regulation IL1B APOE 17510469 1761932 Inhibitory *effects* of on [IL-1beta] signaling were abolished after silencing LDL receptor related protein-1 (LRP1) expression with siRNA . Regulation IL1B ATP2A2 16912431 1602080 An inhibitory *effect* of at therapeutic concentrations on [IL-1beta] production in articular chondrocytes is suggested . Regulation IL1B ATP5O 17295899 1698787 The N-terminus domain of the a2 isoform of vacuolar can *regulate* [interleukin-1beta] production from mononuclear cells in co-culture with JEG-3 choriocarcinoma cells . Regulation IL1B BGN 19605353 2123844 The objective of this study was to define the *role* of in the synthesis and activation of [IL-1beta] . Regulation IL1B BTK 16517732 1530894 In this study , we have investigated the *role* of both in signaling via another TLR ( TLR2 ) and in the production of other proinflammatory cytokines such as [IL-1beta] , IL-6 , and IL-8 . Regulation IL1B C3 8617973 353945 We have investigated the *effects* of and C3a desArg on gene expression and protein synthesis of TNF-alpha and [IL-1 beta] in PBMC . Regulation IL1B C5 1565840 186797 The *effect* of recombinant human ( rhC5a ) on the synthesis of [interleukin-1 beta (IL 1 beta)] was investigated in highly purified human monocytes , isolated by leukapheresis and counter-current elutriation . Regulation IL1B C5 1576247 187319 The *effect* of recombinant human ( rhC5a ) on the synthesis of [interleukin 1 beta (IL-1 beta)] was investigated in human monocytes , isolated by leukapheresis and countercurrent elutriation . Regulation IL1B C5 1769685 174860 These data are interesting , since they indicate a different *regulation* of [IL-1 beta] and IL-6 by the complement fragment . Regulation IL1B C5 2207333 142562 We investigated the *effects* of recombinant ( rC5a ) on gene expression and synthesis of [interleukin-1 beta (IL-1 beta)] and tumor necrosis factor (TNF) in fresh human peripheral blood mononuclear cells ( PBMC ) . Regulation IL1B CA2 10857757 704522 We investigated the *role* of protein kinase C ( PKC ) and in the induction of PMN [IL-1beta] gene expression by GM-CSF . Regulation IL1B CA2 12660148 1105969 We clarify an essential *role* for in ATP induced [IL-1beta] secretion and indicate an additional role of P2X7 receptors as enhancers of the secretory apparatus by which IL-1beta is released . Regulation IL1B CALM3 1411792 201441 In the intracellular signal transduction mechanism for the production of [IL-1 beta] by these cells following IFN-gamma stimulation , protein kinase C and may be *involved* as second messengers . Regulation IL1B CARD16 11536016 854885 Our data suggest that and ICEBERG are intracellular regulators of caspase-1 activation and could *play* a role in the regulation of [IL-1beta] secretion and NF-kappaB activation during the pro-inflammatory cytokine response . Regulation IL1B CARD8 11821383 928883 We demonstrate that interacts physically with caspase-1 and negatively *regulates* caspase-1 dependent [IL-1beta] generation in the THP-1 monocytic cell line . Regulation IL1B CARD8 19319132 2073575 Production of mature [IL-1beta] is *dependent* on a caspase-1 activating protein complex called the NALP3 inflammasome , composed of NALP3 , ASC , and . Regulation IL1B CASP1 10358182 618926 Since caspase-1 is known to cleave proIL-1 beta and proIL-18 into their mature , active forms , we analyzed the *effect* of a specific inhibitor on virus induced [IL-1 beta] and IL-18 production . Regulation IL1B CASP1 10578176 569567 In addition to the well established *role* of in the production of active [IL-1beta] and IL-18 in inflammation,4 an increasing number of reports has recently suggested that caspases may have a function outside of apoptosis . Regulation IL1B CASP1 11246703 793284 IL-1beta secretion was blocked by the caspase-1 inhibitor , Z-VAD-FMK , indicating that is *involved* in not only the induction of apoptosis but also the [IL-1beta] secretion from A. actinomycetemcomitans infected J774.1 cells . Regulation IL1B CASP1 15010463 1243389 The extracellular release of [IL-1beta] and IL-18 in response to anthrax LT is *dependent* , as an ICE-specific inhibitor blocks this process . Regulation IL1B CASP1 15561713 1367958 NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1 mediated activation *play* essential roles in [interleukin-1beta] release from Helicobacter pylori lipopolysaccharide stimulated macrophages . Regulation IL1B CASP1 17429439 1766337 We show here that key components of the inflammasome are present in human keratinocytes and that CS like trinitro-chlorobenzene induce *dependent* [IL-1beta] and IL-18 processing and secretion . Regulation IL1B CASP1 1781424 175891 Probing the *role* of in [interleukin-1 beta] secretion . Regulation IL1B CASP1 18523309 1922916 Inflammatory is *responsible* for the proteolytic activation of [IL-1beta] . Regulation IL1B CASP1 19737897 2186522 The extracellular release of [IL-1beta] in response to PGA was *dependent* , since the administration of an ICE inhibitor prior to PGA treatment blocked induction of IL-1beta . Regulation IL1B CASP1 20442201 2307476 Macrophages incubated with DSS in vitro secreted high levels of [IL-1beta] in a *dependent* manner . Regulation IL1B CASP1 7859282 294919 therefore *plays* a dominant role in the generation of mature [IL-1 beta] , a previously unsuspected role in production of IL-1 alpha , but has no autonomous function in apoptosis . Regulation IL1B CASP1 9341755 458755 It is concluded that psoriatic scales contain biologically active [IL-1 beta] , which has been processed by a mechanism which may be similar to that present in non inflamed plantar stratum corneum , and which does not *involve* . Regulation IL1B CASP1 9427519 472722 That dexamethasone inhibited the expression of ICE , suggests that corticosteroids *regulate* the secretion of [IL-1beta] by microglial cells , in part , by regulating the expression of . Regulation IL1B CASP1 9809553 545376 This [IL-1beta] secretion is *independent* of ( caspase 1 ) , yet it is inhibited by caspase inhibitors , indicating that a caspase ( s ) in addition to IL-1beta converting enzyme can process IL-1beta . Regulation IL1B CAT 10195945 604255 Although AT decreased superoxide release from activated monocytes , superoxide dismutase and had no *effect* on [IL-1 beta] release . Regulation IL1B CD14 9369942 464082 These observations suggest a functional *role* of endogenous in LPS stimulated expression of the [IL-1 beta] gene in the cells . Regulation IL1B CD33 15597323 1361722 Finally , inhibition of phosphoinositide 3-kinase (PI3K) dramatically enhanced the [IL-1 beta] *response* to and neuraminidase , while inhibition of p38 mitogen activated protein kinase (MAPK) abolished it . Regulation IL1B CD38 12718937 1030630 ligation *plays* a direct role in the induction of [IL-1beta] , IL-6 , and IL-10 secretion in resting human monocytes . Regulation IL1B CD40LG 11160202 781499 On the other hand , ATP markedly and dose-dependently inhibited LPS- and soluble *dependent* production of IL-1alpha , [IL-1beta] , TNF-alpha , IL-6 , and IL-12 , whereas IL-1 receptor antagonist and IL-10 production was not affected . Regulation IL1B CD44 14872494 1208466 The action of HA on [IL-1beta] may *involve* direct interaction between HA and on chondrocytes . Regulation IL1B CD69 8660807 365004 These results indicate that CD2 is required for T cell induction of IL-1 beta mRNA through interaction with LFA-3 on the monocyte and that the generation of soluble [IL-1 beta] is *regulated* by . Regulation IL1B CDC73 1710753 158268 The magnitude of the *effects* of on [IL-1 beta] mRNA levels matched closely the effects seen at the level of protein synthesis , suggesting that the effects of PAF on IL-1 beta release may result largely from its effects on IL-1 beta mRNA levels . Regulation IL1B CDC73 2293896 127473 To assess the *effect* of on [IL-1 beta] synthesis , THP-1 cell pellet proteins were separated by SDS-PAGE , blotted , and immunostained to detect IL-1 beta . Regulation IL1B CDCA2 16729332 1565766 Human primary hepatocytes and HepG2 cells were used as models to study and [interleukin-1 beta (IL-1 beta)] *regulation* of human CYP7A1 gene expression via real-time polymerase chain reaction , reporter assays , co-immunoprecipitation and chromatin immunocipitation ( ChIP ) assays . Regulation IL1B CDCA3 16729332 1565767 Human primary hepatocytes and HepG2 cells were used as models to study and [interleukin-1 beta (IL-1 beta)] *regulation* of human CYP7A1 gene expression via real-time polymerase chain reaction , reporter assays , co-immunoprecipitation and chromatin immunocipitation ( ChIP ) assays . Regulation IL1B CDCA4 16729332 1565768 Human primary hepatocytes and HepG2 cells were used as models to study and [interleukin-1 beta (IL-1 beta)] *regulation* of human CYP7A1 gene expression via real-time polymerase chain reaction , reporter assays , co-immunoprecipitation and chromatin immunocipitation ( ChIP ) assays . Regulation IL1B CDCA5 16729332 1565769 Human primary hepatocytes and HepG2 cells were used as models to study and [interleukin-1 beta (IL-1 beta)] *regulation* of human CYP7A1 gene expression via real-time polymerase chain reaction , reporter assays , co-immunoprecipitation and chromatin immunocipitation ( ChIP ) assays . Regulation IL1B CDCA7 16729332 1565770 Human primary hepatocytes and HepG2 cells were used as models to study and [interleukin-1 beta (IL-1 beta)] *regulation* of human CYP7A1 gene expression via real-time polymerase chain reaction , reporter assays , co-immunoprecipitation and chromatin immunocipitation ( ChIP ) assays . Regulation IL1B CDCA8 16729332 1565771 Human primary hepatocytes and HepG2 cells were used as models to study and [interleukin-1 beta (IL-1 beta)] *regulation* of human CYP7A1 gene expression via real-time polymerase chain reaction , reporter assays , co-immunoprecipitation and chromatin immunocipitation ( ChIP ) assays . Regulation IL1B CDK9 10080875 597470 *Involvement* of NF-kappaB p50/p65 in activation of the human [pro-interleukin-1beta] gene at two subregions of the upstream enhancer element . Regulation IL1B CEBPB 15561713 1367959 NF-kappaB- and interleukin-1beta gene expression and PAK1 mediated caspase-1 activation *play* essential roles in [interleukin-1beta] release from Helicobacter pylori lipopolysaccharide stimulated macrophages . Regulation IL1B CFTR 11278608 802691 These results indicate that NF-kappaB is involved in the pathway by which [IL-1beta] *regulates* . Regulation IL1B CGA 1572315 187226 These observations along with the demonstration of the *dependent* preovulatory induction of ovarian [IL-1 beta] gene expression provide strong support for the view that IL-1 may be the centerpiece of an intraovarian regulatory loop concerned with the promotion of the preovulatory cascade . Regulation IL1B CGB8 1572315 187225 These observations along with the demonstration of the *dependent* preovulatory induction of ovarian [IL-1 beta] gene expression provide strong support for the view that IL-1 may be the centerpiece of an intraovarian regulatory loop concerned with the promotion of the preovulatory cascade . Regulation IL1B CHUK 16286467 1509594 In the present report , we describe a mechanism whereby [interleukin-1beta (IL-1beta)] stimulation of NFkappaB is partially *regulated* by H2O2 mediated activation of NIK and subsequent NIK mediated phosphorylation of . Regulation IL1B CISH 7976083 281162 In order to investigate the mechanism of urocanic acid ( UCA ) -mediated immune modulation , we studied the *effect* of and trans-UCA on [interleukin-1 beta] and tumour necrosis factor-alpha production by human peripheral blood monocytes , using immunospecific ELISA techniques . Regulation IL1B CLEC6A 20493731 2270240 The yeast form of C. albicans induced [interleukin-1beta (IL-1beta)] and IL-23 secretion in a *dependent* manner . Regulation IL1B CNTF 9459616 475740 The inhibitory *effect* of on [IL-1beta] activities on nervous cells was confirmed in the IL-6 production assay . Regulation IL1B COP 11432859 850293 Our data indicate that can *regulate* [IL-1beta] secretion , implying that COP may play a role in down regulating inflammatory responses analogous to the CARD protein ICEBERG . Regulation IL1B CRH 10209072 607371 The different *regulation* of IL-1alpha and [IL-1beta] pro-inflammatory activities by may attribute special precision and specificity to the neuroendocrine-immune control of inflammatory processes . Regulation IL1B CRH 17326013 1706517 However , had no *effect* on interleukin-1alpha and [interleukin-1beta] production in these cells . Regulation IL1B CRH 7588301 333842 We have studied the *effects* of ( 0.1-100 nM ) on [IL-1 beta] and IL-1ra expression by human peripheral monocytes in culture activated with different doses of lipopolysaccharide (LPS) . Regulation IL1B CRH 9425615 472573 In this study we used a previously validated technique to investigate the *effects* of classical neurotransmitters and the hypophysiotropic peptide on the release of immunoreactive ( ir ) [IL-1 beta] from acute rat hypothalamic explants . Regulation IL1B CROT 19689369 2126541 kinase activation *plays* an integral role in the production of pro-inflammatory cytokines such as TNF and [IL-1beta] in this immune cell type . Regulation IL1B CSDE1 19454352 2084494 The known fungal pattern recognition receptors TLR2 and Dectin-1 regulate IL-1beta gene transcription , whereas the NLRP3 containing proinflammatory , the NLRP3 inflammasome , *controls* caspase-1 mediated cleavage of [pro-IL-1beta] . Regulation IL1B CSF1 1536949 180495 [Interleukin-1 beta (IL-1 beta)] expression in human blood mononuclear phagocytes is differentially *regulated* by granulocyte-macrophage colony stimulating factor ( GM-CSF ) , , and IL-3 . Regulation IL1B CSF2 1536949 180496 [Interleukin-1 beta (IL-1 beta)] expression in human blood mononuclear phagocytes is differentially *regulated* by granulocyte-macrophage ( GM-CSF ) , M-CSF , and IL-3 . Regulation IL1B CSF2 2212667 142732 Although recently polymorphonuclear leukocytes ( PMN ) have been identified as producers of [IL-1 beta] in *response* to LPS and granulocyte/monocyte , little is known regarding the ability of other cytokines to induce the production of IL-1 beta in the PMN . Regulation IL1B CSF2 8219777 231821 The present studies were designed to examine the regulatory *effect* of on TNF-alpha and [IL-1 beta] production by AM and PM from patients with pulmonary sarcoidosis . Regulation IL1B CSF2 9038318 415453 Involvement of mannose receptor in cytokine [interleukin-1beta (IL-1beta)] , IL-6 , and granulocyte-macrophage *responses* , but not in chemokine macrophage inflammatory protein 1beta ( MIP-1beta ) , MIP-2 , and KC responses , caused by attachment of Candida albicans to macrophages . Regulation IL1B CTNNB1 12147254 970005 We investigated in this study the *role* of in the [IL-1beta] regulation of COX-2 expression in articular chondrocytes . Regulation IL1B CTR9 1710753 158269 The magnitude of the *effects* of on [IL-1 beta] mRNA levels matched closely the effects seen at the level of protein synthesis , suggesting that the effects of PAF on IL-1 beta release may result largely from its effects on IL-1 beta mRNA levels . Regulation IL1B CTR9 2293896 127474 To assess the *effect* of on [IL-1 beta] synthesis , THP-1 cell pellet proteins were separated by SDS-PAGE , blotted , and immunostained to detect IL-1 beta . Regulation IL1B CTSB 12726991 1086350 Results show that in normal conditions and in the presence of [IL-1beta] , is *involved* in the activation of PA . Regulation IL1B CUX1 8239305 236118 Since interleukin-1 (IL-1) is an APP gene promoter showing a progressive increase in body fluids in parallel with mental deterioration in AD patients , we have studied the *effects* of on cognition , several biological parameters , and [IL-1 beta] production in AD and multi-infarct dementia (MID) in order to elucidate whether this compound alone or in combination with other drugs is able to restore immune function and improve mental performance in senile dementia . Regulation IL1B CXCL9 10194182 603784 However , does not *affect* LPS induced release of [IL-1beta] and does not protect from a lethal dose of LPS in unsensitized mice . Regulation IL1B CYP2A 19589095 2105278 Furafylline , a inhibitor , and indomethacin , a PGHS inhibitor , exhibited a significant inhibitory *effect* on TNFalpha and [IL-1beta] production induced by the APAP and LPS combination . Regulation IL1B DAPK1 18292548 1872958 In contrast , [IL-1beta-] and TNF-alpha triggered NF-kappaB activation was not *affected* by . Regulation IL1B DAPK2 18292548 1872959 In contrast , [IL-1beta-] and TNF-alpha triggered NF-kappaB activation was not *affected* by . Regulation IL1B DAPK3 18292548 1872960 In contrast , [IL-1beta-] and TNF-alpha triggered NF-kappaB activation was not *affected* by . Regulation IL1B DDX58 18209072 1857822 In this study , we have studied the *role* of membrane associated TLRs and cytoplasmic receptors ( RLR ) in regulation of IFN-beta , IL-29 , [IL-1beta] , and IL-18 production and caspases 1 and 3 activation in human macrophages . Regulation IL1B DSG1 10442743 635760 We further studied the *effect* of <15-DSG> on the expression of [interleukin-1beta (IL-1beta)] in peritoneal exudate mononuclear cells ( PEMCs ) using reverse transcription-polymerase chain reaction . Regulation IL1B DUSP1 15485842 1347354 Our results reveal that critically *regulates* the expression of TNF-alpha and [interleukin-1 beta] in RAW264.7 cells and further suggest a central role for this phosphatase in controlling the inflammatory responses of primary macrophages to Gram positive bacterial infection . Regulation IL1B EBP 18247123 1865219 Our studies demonstrate that [IL-1beta] induces C3 promoter activity in a *dependent* manner . Regulation IL1B EDN1 15209387 1261784 To determine if magnesium sulfate ( MgSO4 ) attenuates the vasoconstrictor effect of angiotensin II (Ag II) , and thromboxane mimetic ( TX ) in the human fetal placental vasculature and if [interleukin-1 beta (IL-1beta)] is *involved* in this process . Regulation IL1B EDN1 20051644 2177410 We determined the protein levels of ET-1 and IL-1beta in gingival tissues from patients and examined whether could *regulate* the expression of the [IL-1beta] gene and protein in oral epithelial cells and fibroblasts in vitro . Regulation IL1B EDN1 20051644 2177414 These findings indicate that is *involved* in the regulation of [IL-1beta] expression in gingival tissues and suggest that ET-1 signaling to the cells may be a therapeutic target for treating IL-1beta dependent inflammatory responses . Regulation IL1B EDNRA 11854220 913525 Similarly , a milder *effect* of on [IL-1 beta] and IL-18 was observed for IRF-1 KO than for WT mice . Regulation IL1B EEF1A2 15654265 1364411 Therefore , the aim of the study was to asses the *effect* of and fibrate therapy ( for dyslipidemia IIa and IIb , respectively ) on [IL-1beta] gene expression and monocyte release evaluated in each patient . Regulation IL1B EGF 1940795 170623 Regulation of cytokine production in the human thymus : and transforming growth factor alpha *regulate* mRNA levels of interleukin 1 alpha (IL-1 alpha) , [IL-1 beta] , and IL-6 in human thymic epithelial cells at a post-transcriptional level . Regulation IL1B EGR1 12734378 1087366 Our results indicate that A beta induced expression of cytokines ( TNF-alpha and [IL-1 beta] ) and chemokines ( MCP-1 , IL-8 , and MIP-1 beta ) in THP-1 monocytes *involves* activation of ERK-1/ERK-2 and downstream activation of . Regulation IL1B EHMT1 12108020 963140 The production of TNF-alpha and [IL-1 beta] was not *affected* by MEP and at the concentrations which significantly inhibited the proliferative activity and T cell derived cytokine production . Regulation IL1B ENTPD1 20201036 2248976 Consistent with these observations , *regulated* P2X7 associated [IL-1beta] release after synthesis , and this process occurred independently of , and prior to , cytokine maturation by caspase-1 . Regulation IL1B EPHB2 19299480 2106082 In the present study , we demonstrate that CGRP is involved in morphine tolerance by differentially regulating the *dependent* up-regulation of [IL-1beta] , TNF-alpha , and microsomal prostaglandin E synthase-1 ( mPGES-1 ) in astrocytes and p38 dependent up-regulation of IL-6 in microglia in the rat spinal cord . Regulation IL1B EPO 10489101 645338 The *effect* of on [interleukin-1beta] mediated increase in nitric oxide synthesis in vascular smooth muscle cells . Regulation IL1B EPO 9386984 466445 These findings suggest that systemic TNF alpha or [IL-1 beta] are not involved in the *response* to ACD . Regulation IL1B ESX1 18503637 1958404 Collectively , these results reveal a *role* for in triggering secretion of lysosomes , as well as release of [IL-1beta] and IL-18 during mycobacteria infection . Regulation IL1B FAS 16785543 1577120 We additionally determined that [IL-1beta] and TNF-alpha secretion by beta-glucan stimulated DCs was partially *regulated* by . Regulation IL1B FASLG 16785543 1577121 We additionally determined that [IL-1beta] and TNF-alpha secretion by beta-glucan stimulated DCs was partially *regulated* by . Regulation IL1B FGB 10226077 610372 This study begins to define the molecular mechanisms by which promotes and *regulates* expression of the [IL-1beta] gene and further substantiates a role for fibrin(ogen) in tissue injury and inflammation . Regulation IL1B FGB 18380966 1892791 [ *Effect* of on the secretion of [interleukin-1beta] and - 8 by polymorphonuclear leukocytes ] . Regulation IL1B FGF1 9389745 467313 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Regulation IL1B FGF1 9555020 499623 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Regulation IL1B FGF10 9389745 467314 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Regulation IL1B FGF10 9555020 499624 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Regulation IL1B FGF11 9389745 467315 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Regulation IL1B FGF11 9555020 499625 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Regulation IL1B FGF12 9389745 467316 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Regulation IL1B FGF12 9555020 499626 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Regulation IL1B FGF13 9389745 467317 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Regulation IL1B FGF13 9555020 499627 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Regulation IL1B FGF14 9389745 467318 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Regulation IL1B FGF14 9555020 499628 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Regulation IL1B FGF16 9389745 467319 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Regulation IL1B FGF16 9555020 499629 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Regulation IL1B FGF17 9389745 467320 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Regulation IL1B FGF17 9555020 499630 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Regulation IL1B FGF18 9389745 467321 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Regulation IL1B FGF18 9555020 499631 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Regulation IL1B FGF19 9389745 467322 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Regulation IL1B FGF19 9555020 499632 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Regulation IL1B FGF2 9389745 467323 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Regulation IL1B FGF2 9555020 499633 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Regulation IL1B FGF20 9389745 467324 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Regulation IL1B FGF20 9555020 499634 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Regulation IL1B FGF21 9389745 467325 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Regulation IL1B FGF21 9555020 499635 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Regulation IL1B FGF22 9389745 467326 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Regulation IL1B FGF22 9555020 499636 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Regulation IL1B FGF23 9389745 467327 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Regulation IL1B FGF23 9555020 499637 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Regulation IL1B FGF3 9389745 467328 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Regulation IL1B FGF3 9555020 499638 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Regulation IL1B FGF4 9389745 467329 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Regulation IL1B FGF4 9555020 499639 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Regulation IL1B FGF5 9389745 467330 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Regulation IL1B FGF5 9555020 499640 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Regulation IL1B FGF6 9389745 467331 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Regulation IL1B FGF6 9555020 499641 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Regulation IL1B FGF7 9389745 467332 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Regulation IL1B FGF7 9555020 499642 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Regulation IL1B FGF8 9389745 467333 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Regulation IL1B FGF8 9555020 499643 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Regulation IL1B FGF9 9389745 467334 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced nitric oxide synthase expression in rat renal mesangial cells . Regulation IL1B FGF9 9555020 499644 Platelet derived growth factor and differentially *regulate* [interleukin 1beta-] and cAMP induced group II phospholipase A2 expression in rat renal mesangial cells . Regulation IL1B FN1 11052809 743451 Transcriptional *regulation* of the human [interleukin 1beta] gene by : role of protein kinase C and activator protein 1 (AP-1) . Regulation IL1B GCG 16720054 1570303 In this study , we investigated the expression of and its receptor , and the *effects* of GLP-1 on lipopolysaccharide (LPS) induced [IL-1beta] mRNA expression and IL-1beta production in glia . Regulation IL1B GH1 9678530 520689 Modulating *effect* of human on tumour necrosis factor-alpha and [interleukin-1beta] . Regulation IL1B GNA13 16778360 1576832 These results suggest that *regulates* [IL-1beta] mRNA induction through the reactive oxygen species-NF-kappaB pathway , while it regulates IL-6 mRNA induction through the Ca2+-NF-kappaB pathway . Regulation IL1B GNRH1 18937699 1978009 To test the relevance of this interaction during embryonic implantation , we investigated *regulation* of [IL-1b] and IL-1ra mRNA and protein expression in human endometrial stromal cells using quantitative competitive polymerase chain reaction and ELISA . Regulation IL1B GPI 1837029 175088 Interleukin-6 induction by FcRI stimulation is not mediated solely by FcRI induced M phi tumor necrosis factor alpha , IL-1 alpha , or [IL-1 beta] production and is *independent* of M prostaglandin E2 levels . Regulation IL1B GRAP2 10089132 600006 Because NF-kappaB is necessary for MCP-1 gene expression , the *effect* of kinase inhibition on [IL-1beta] induction of NF-kappaB was measured . Regulation IL1B GRAP2 10202024 605914 Lastly , we demonstrated that kinase activity *played* a central role in [IL-1beta] production and that it was rapidly up-regulated following infection . Regulation IL1B GRAP2 14998552 1216646 Results indicated that both and ERK pathways are *involved* in LPS stimulated NO synthesis and the expression of [IL-1beta] and IL-6 . Regulation IL1B GRM3 15652990 1364387 The *effect* of activation on [IL-1beta] stimulated release of IL-6 was prevented by selective group II mGluR antagonists . Regulation IL1B GRP 8982099 403800 In the present study , we have investigated the *effect* in vitro of ( GRP , 10 ( -10 ) M ) , neuropeptide Y ( NPY , 10 ( -10 ) M ) , somatostatin ( 10 ( -10 ) M ) and vasoactive intestinal peptide ( VIP , 10 ( -9 ) M ) on the production of [IL-1 beta] , IL-6 and TNF alpha by peripheral whole blood cells from healthy young and old people . Regulation IL1B HDAC1 16684958 1598528 In the present study , we investigated the *effects* of 2 inhibitors on [IL-1beta] secretion : suberoylanilide hydroxamic acid and a newly developed hydroxamic acid derived compound ITF2357 . Regulation IL1B HDAC1 16684958 1598532 These inhibitors do not *affect* the synthesis or intracellular localization of [IL-1beta] but both strongly reduce the levels of extracellular IL-1beta by preventing the exocytosis of IL-1beta containing secretory lysosomes . Regulation IL1B HDAC2 16684958 1598529 In the present study , we investigated the *effects* of 2 inhibitors on [IL-1beta] secretion : suberoylanilide hydroxamic acid and a newly developed hydroxamic acid derived compound ITF2357 . Regulation IL1B HDAC2 16684958 1598533 These inhibitors do not *affect* the synthesis or intracellular localization of [IL-1beta] but both strongly reduce the levels of extracellular IL-1beta by preventing the exocytosis of IL-1beta containing secretory lysosomes . Regulation IL1B HGF 19171123 2043611 Furthermore , the inhibitory *effect* of on up-regulation of [interleukin-1beta] and interleukin-18 was largely restored by SnPP . Regulation IL1B HNRNPD 19454352 2084495 The known fungal pattern recognition receptors TLR2 and Dectin-1 regulate IL-1beta gene transcription , whereas the NLRP3 containing proinflammatory , the NLRP3 inflammasome , *controls* caspase-1 mediated cleavage of [pro-IL-1beta] . Regulation IL1B HSP90AA1 17599753 1774581 The aim of this study was to investigate the *roles* of age and in insulin-like growth factor 1 (IGF-1) and [interleukin-1beta (IL-1beta)] signaling in chondrocytes . Regulation IL1B HSPG2 17158358 1716901 In this study we investigated the *role* of phosphatidylcholine-specific phospholipase C ( ) in silica stimulated induction of TNF-alpha and [IL-1beta] and how PC-PLC activity is regulated by silica in a rat alveolar macrophage model . Regulation IL1B HYAL1 18390475 1944188 We found that activity is present in the apical and basolateral secretions from HBE cells where Hyals 1 , 2 , and 3 are expressed , and that [IL-1beta] *acts* synergistically with TNF-alpha to increase gene expression and activity . Regulation IL1B HYAL2 18390475 1944189 We found that activity is present in the apical and basolateral secretions from HBE cells where Hyals 1 , 2 , and 3 are expressed , and that [IL-1beta] *acts* synergistically with TNF-alpha to increase gene expression and activity . Regulation IL1B HYAL3 18390475 1944190 We found that activity is present in the apical and basolateral secretions from HBE cells where Hyals 1 , 2 , and 3 are expressed , and that [IL-1beta] *acts* synergistically with TNF-alpha to increase gene expression and activity . Regulation IL1B HYAL4 18390475 1944191 We found that activity is present in the apical and basolateral secretions from HBE cells where Hyals 1 , 2 , and 3 are expressed , and that [IL-1beta] *acts* synergistically with TNF-alpha to increase gene expression and activity . Regulation IL1B IAPP 10693932 671263 Both lipopolysaccharide treated THP-1 monocytes and mouse microglia showed significant increases in mature interleukin-1beta release 48 h following amyloid beta or human amylin treatment , whereas nonfibrillar rat had no *effect* on [interleukin-1beta] production by THP-1 cells . Regulation IL1B IFI44 17395477 1728144 In the present study the quantitative *role* of and p38 in the production of TNF-alpha , [IL-1beta] and IL-12 by murine peritoneal macrophages , in vitro , on treatment with Concanavalin A ( ConA ) has been investigated . Regulation IL1B IFNB1 14698849 1195814 Here we compare modulatory *effects* of on the production of proinflammatory cytokines ( [IL-1beta] , IL-1alpha , TNF , and IL-6 ) and IL-1Ra in human monocytes stimulated by lipopolysaccharides (LPS) and isolated plasma membranes of stimulated T cells ( msHUT ) , which are likely to reflect monocyte activation in acute and chronic inflammation , respectively . Regulation IL1B IFNG 11665984 872289 Endogenous *plays* a role in the regulation of [IL-1beta] , in this model of autoimmune arthritis . Regulation IL1B IFNG 11937564 928222 *dependent* induction of IL-6 , [IL-1beta] , TNF-alpha , inducible NO synthase , and plasminogen activator inhibitor-1 mRNAs was variably impaired , while IL-12 p40 , RANTES and macrophage inflammatory protein-1beta mRNAs were up-regulated in the absence of C/EBPbeta . Regulation IL1B IFNG 12789234 1097434 [IL-1beta] also increased VEGF production , but this was not *affected* by ( P > .05 ) . Regulation IL1B IFNG 15236748 1269737 In contrast , NOD macrophages failed to up-regulate [IL1beta] and IL12p40 in *response* to . Regulation IL1B IFNG 1697308 139526 In our study , we have further examined *effects* on both TNF and [IL-1 beta] responses . Regulation IL1B IFNG 17394800 1721065 These results indicate that exogenous *affects* the expression of [IL-1beta] and inhibits ESC proliferation . Regulation IL1B IFNG 18506884 1928275 PGE ( 2 ) counters the *effects* of , on the release of IP-10 , IL-8 , TNF-alpha and [IL-1beta] . Regulation IL1B IFNG 18550018 1923759 Feeding the ginsenoside diet resulted in lower ( P < 0.05 ) spleen IL-2 production , but the , TNF-alpha and [IL-1beta] *response* to ConA was not different from control animals at 48 h . Regulation IL1B IFNG 18586252 2019914 Results showed that high glucose and had a synergistic *effect* on the expression of MMP-1 , MMP-9 and [IL-1 beta] . Regulation IL1B IFNG 19929594 2171917 does not *affect* the transient activation of classical NF-kappaB by [IL-1beta] and synergistic induction of ip-10 expression by IFN-gamma and IL-1beta occurs even after the activation of classical NF-kappaB has returned to basal levels . Regulation IL1B IFNG 20307272 2273078 did not *affect* [IL-1beta] induced tissue inhibitor of metalloproteinase-1 ( TIMP-1 ) production by RA FLS but skewed the MMP/TIMP-1 balance sufficiently to attenuate glycosaminoglycan-depletion in our BACE model . Regulation IL1B IFNG 20596075 2296441 *Regulation* of [interleukin-1beta] by is species specific , limited by suppressor of cytokine signalling 1 and influences interleukin-17 production . Regulation IL1B IFNG 20596075 2296442 Reports describing the *effect* of on [interleukin-1beta (IL-1beta)] production are conflicting . Regulation IL1B IFNG 2111375 132930 The *role* of in stimulating [IL-1 beta] secretion was not related to an enhancement of viability or an increase in the proportion of mezerein treated cells synthesizing DNA . Regulation IL1B IFNG 2509610 120470 To determine if the release of IL-1 alpha and IL-1 beta by cultured PBMC could be independently modulated by different exogenous stimuli , we examined the *effect* of LPS , , latex beads , and indomethacin on the release of IL-1 alpha and [IL-1 beta] . Regulation IL1B IFNG 2524582 112017 Because IFN-gamma can influence LPS stimulated responses , the *effect* of on the LPS stimulated release of PGE2 and [IL-1 beta] was also assessed . Regulation IL1B IFNG 7595061 334844 Northern blotting studies revealed no *effect* of alone on [IL-1 beta] or TNF-alpha mRNA production . Regulation IL1B IFNG 7927171 273881 In addition , the *effects* of on ISO relaxation and [IL-1 beta] on KCl contraction were abolished by indomethacin but not by N omega-nitro-L-arginine methyl ester ( N omega-NAME ) . Regulation IL1B IFNG 8260535 238830 In this study we investigated the *effect* of the T cell product on the glucocorticoid mediated and on the IL-4 mediated inhibition of IL-1 beta mRNA and [IL-1 beta] protein synthesis in highly purified human monocytes . Regulation IL1B IFNG 8439987 213286 Generally , arabinogalactan pretreatment induced an increased release of interferon gamma (IFN gamma) , tumor necrosis factor alpha , [interleukin-1 beta (IL-1 beta)] and IL-6 but only was *involved* in enhancement of NK cytotoxicity since cytotoxicity enhancement of PBMC and PNAC but not that of monocytes could be blocked when anti-IFN gamma antibodies were present during pretreatment . Regulation IL1B IFNG 8647201 366281 In the present study , we have examined the *effect* of on the expression of the [IL-1 beta] gene in mouse RAW 264.7 macrophages activated by lipopolysaccharide (LPS) plus tumor necrosis factor (TNF)-alpha . Regulation IL1B IFNG 8808791 382949 Inhibitory *effect* of on LPS induced [interleukin 1 beta] production by isolated adult rat brain microglia . Regulation IL1B IFNG 9106231 424390 Cultures of human fetal astrocytes and microglia produce inducible nitric oxide synthase and nitric oxide in *response* to and [Interleukin 1 beta] . Regulation IL1B IFNG 9520166 493477 In contrast , release of [IL-1beta] and IL-1ra ( IL-1 receptor antagonist ) in *response* to LPS , or LPS plus , was found to be lower in PMN from HIV positive patients than in PMN from controls , but was significant only in the case of IL-1ra . Regulation IL1B IFNGR2 18541446 1952073 The inhibitory *effects* of on [IL-1beta] were significantly decreased when endogenous production of IL-10 was blocked . Regulation IL1B IGF1 12746901 1088822 The *effects* of on the expression of IGF-1 , IL-1alpha , and [IL-1beta] and their respective receptor systems , the aggrecan core protein , and CII were determined by flow cytometry . Regulation IL1B IL10 10088668 599959 Interleukin-4 and *regulate* [IL1-beta] induced mouse primary astrocyte activation : a comparative study . Regulation IL1B IL10 10452106 637589 Both endogenous and exogenous nitric oxide and had inhibitory *effects* on the LPS induced TNF alpha , [IL-1 beta] , and IL-6 secretions in mouse AM . Regulation IL1B IL10 11052826 743477 High plasma levels at diagnosis of ALL had no *effect* on the ex vivo TNF-alpha and [IL-1beta] production of monocytes in LPS stimulated MNC cultures . Regulation IL1B IL10 1387585 196262 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL10 14977992 1213347 Mycobacterial purified protein derivatives stimulate innate immunity : Malawians show enhanced tumor necrosis factor alpha , [interleukin-1beta (IL-1beta)] , and *responses* compared to those of adolescents in the United Kingdom . Regulation IL1B IL10 14977992 1213351 To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom , we examined 24-h tumor necrosis factor alpha , [interleukin-1beta (IL-1beta)] , and *responses* to mycobacterial purified protein derivatives ( PPDs ) . Regulation IL1B IL10 18218915 1890337 *Effects* of and age on IL-6 , [IL-1beta] , and TNF-alpha responses in mouse skeletal and cardiac muscle to an acute inflammatory insult . Regulation IL1B IL10 2112081 133033 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL10 7540642 310126 Seven-day cultured monocytes/macrophages showed ( 1 ) diminished TNF-alpha production in response to IL-10 but not IL-4 ( 2 ) , diminished [IL-1 beta] production in *response* to both IL-4 and , and compared with fresh monocytes ( 3 ) , diminished CD14 expression in response to IL-4 , and ( 4 ) a lesser increase in CD23 expression in response to IL-4 . Regulation IL1B IL10 8186324 256684 The *effects* of on interleukin-1 receptor antagonist and [interleukin-1 beta] production in human monocytes and neutrophils . Regulation IL1B IL10 8301137 248698 These results suggest that [IL-1 beta] , IL-4 , and *control* the survival and differentiation of human monocytes through a regulation of autocrine M-CSF production . Regulation IL1B IL10 8613550 353560 Whereas the in vivo regulatory effects of IL-1R appear to be limited to IL-1beta , *regulates* both [IL-1beta] and TNF-alpha in this model , reflected by a 48 % increase in BAL IL-1beta in rats treated with anti-IL-10 . Regulation IL1B IL10 8646564 343022 We investigated the *effects* of on brain TNF and [IL-1 beta] production induced by a central LPS administration in mice . Regulation IL1B IL10 8698522 372901 Endogenous was *involved* in regulating tumor necrosis factor alpha and [IL-1beta] secretion by human monocytes in response to encapsulated C. neoformans strains . Regulation IL1B IL10 9192163 437744 *Effects* of on [IL-1 beta] ( 0.2 or 2 ng/ml ) - , or TNF-alpha ( 0.2 or 2 ng/ml ) -induced IL-8 and MCP-1 secretion and gene expression were assessed using enzyme linked immunosorbent assay ( ELISA ) and Northern blot analysis . Regulation IL1B IL10 9683557 521440 The *effects* of on proinflammatory cytokine expression ( [IL-1beta] and IL-8 ) in hyaline membrane disease ( HMD ) . Regulation IL1B IL11 1387585 196263 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL11 2112081 133034 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL12B 18164424 1875366 We also found that IL-17 was produced by microglia in *response* to or [IL-1beta] . Regulation IL1B IL13 1387585 196264 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL13 2112081 133035 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL13 8894439 392366 The *effect* of interleukin 4 (IL-4) and on IL-6 and [IL-1 beta] production by human embryonic microglial cells and human peripheral blood monocyte cells ( PBMC ) was compared . Regulation IL1B IL13 9550283 477745 In the present study we examined the *effect* of on [IL-1beta] suppression of islet function . Regulation IL1B IL13 9616438 509618 We examined the *effect* of on the synthesis and expression of [interleukin-1 beta (IL-1 beta)] , tumor necrosis factor-alpha (TNF-alpha) , IL-1 receptor antagonist (IL-1Ra) and stromelysin-1 on human OA synovial membrane in ex vivo cultures . Regulation IL1B IL15 1387585 196265 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL15 20620944 2286636 IL-1R1 ( hi ) iNK cells required continuous exposure to IL-1beta to retain AHR and IL-22 expression , and they proliferate in direct *response* to cDC derived and [IL-1beta] . Regulation IL1B IL15 2112081 133036 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL16 1387585 196266 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL16 2112081 133037 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL17D 20416175 2246568 It is concluded that the may *regulate* the expression of Mac-1 , fMLP-R and [IL-1beta] in human neutrophils through p38 MAPK and PI3K signal pathways . Regulation IL1B IL18 11570642 864283 *Role* of in the secretion of [Il-1beta] , sIL-1RII , and IL-1Ra by human neutrophils . Regulation IL1B IL18 12022703 943285 *Effect* of on [IL-1beta] and sIL-1RII production by human neutrophils . Regulation IL1B IL18 12022703 943287 In the present study we investigated the *effect* of on the production of [IL-1beta] and soluble IL-1 receptor II ( sIL-1RII ) by human neutrophils . Regulation IL1B IL18 1387585 196267 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL18 2112081 133038 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL19 1387585 196268 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL19 2112081 133039 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL1A 10775179 686539 In the present study we examined the *involvement* of , -1beta , FSH , and lipopolysaccharide (LPS) in the regulation of [IL-1alpha and -1beta] production by Sertoli cells under in vitro conditions . Regulation IL1B IL1A 11238536 790746 *regulation* of [IL-1beta] and IL-1 receptor antagonist expression in cultured human endometrial stromal cells . Regulation IL1B IL1A 1292636 207782 NMRI/KI thymocytes showed the most prominent proliferation in *response* to and [IL-1 beta] . Regulation IL1B IL1A 15036245 1223863 We compared the production of IL-1alpha , [IL-1beta] , and of IL-1Ra isoforms by cultured human dermal ( HDF ) and synovial fibroblasts ( HSF ) in *response* to , TNF-alpha , or direct T cell membrane contact . Regulation IL1B IL1A 18516292 1918513 Recruitment of myeloid cells requires [IL-1beta] but is *regulated* by , because inflammatory chemokine and cytokine expression is stronger in IL-1alpha ( -/- ) beta ( comp ) than in IL-1 ( wt ) lines . Regulation IL1B IL1A 18664535 1967264 Increased messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and *regulation* of [IL-1beta] in human islets by glucose and autostimulation . Regulation IL1B IL1A 1918980 168449 Thus , we report that and TNF *regulate* [IL-1 beta] gene expression via both transcriptional and post-transcriptional mechanisms in vitro . Regulation IL1B IL1A 9094444 406382 Using recombinant IL-1 receptor antagonist we established that endogenously produced *affects* induction of [IL-1beta] protein by lipopolysaccharide (LPS) at the level of mRNA expression . Regulation IL1B IL1A 9249578 446840 To evaluate the *role* of residual production in [IL-1 beta] -/- mice , we used IL-1-receptor antagonist (IL-1ra) . Regulation IL1B IL1RAP 9681388 521136 Interleukin-1 mediated febrile responses in mice and [interleukin-1 beta] activation of NFkappaB in mouse primary astrocytes , *involves* the . Regulation IL1B IL1RN 18675261 1960762 This study examines the participation of [IL-1beta] and its *regulation* by the endogenous ( IL-1ra ) in glutamate toxicity following SCI. Glutamate , glutamatergic agonists and SCI had similar effects on levels of IL-1beta and IL-1ra . Regulation IL1B IL1RN 19152833 2038071 Neither LPS nor *affected* [IL-1beta] mRNA levels in adults , presumably because any effect of LPS had dissipated by 24h . Regulation IL1B IL1RN 7485466 326854 These results are suggestive of an autocrine *role* for cell associated , as well as for IL-1 alpha and [IL-1 beta] , in the regulation of VSMC function . Regulation IL1B IL1RN 8613550 353562 These findings suggest that is an intrinsic regulator of inflammatory injury after deposition of IgG immune complexes and that it *regulates* production of [IL-1beta] . Regulation IL1B IL1RN 8891760 392048 We examined the *participation* of endogenous in the production of [IL-1 beta] in vitro . Regulation IL1B IL1RN 9353596 461560 1 . ( IL-1Ra ) , as well as the [interleukin-1 beta (IL-1 beta)] gene *response* to immobilization stress ( IMS ) , was examined in the rat brain . Regulation IL1B IL2 1387585 196269 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL2 2112081 133040 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL2 2144468 140065 [Pro-interleukin-1 beta] production by a subpopulation of human T cells , but not NK cells , in *response* to . Regulation IL1B IL2 2144468 140069 We examined cytokine production by IL-2 treated , nonmonocytic PBMC and found that a population of nonadherent low-density cells ( NLDC ) produced both [IL-1 beta] and TNF alpha in *response* to . Regulation IL1B IL2 2945861 64435 Neither , phorbol myristic acid , nor lipopolysaccharide *affected* the total binding of [125I-IL 1 beta] by YT cells . Regulation IL1B IL2 3143761 101046 In addition , Leu M3+ monocytes obtained through FACS , but not CD16+ NK cells , produced both IL-1 alpha and [IL-1 beta] in *response* to . Regulation IL1B IL2 9300716 453883 Furthermore , anti-CD14 mAbs effectively inhibited the secretion of IL-8 and [IL-1beta] in *response* to . Regulation IL1B IL20 1387585 196270 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL20 2112081 133041 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL21 1387585 196271 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL21 2112081 133042 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL22 1387585 196254 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL22 2112081 133025 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL23A 18164424 1875365 We also found that IL-17 was produced by microglia in *response* to or [IL-1beta] . Regulation IL1B IL24 1387585 196252 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL24 2112081 133022 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL25 1387585 196253 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL25 2112081 133024 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL26 1387585 196258 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL26 2112081 133029 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL27 1387585 196259 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL27 2112081 133030 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL3 1387585 196272 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL3 1536949 180497 [Interleukin-1 beta (IL-1 beta)] expression in human blood mononuclear phagocytes is differentially *regulated* by granulocyte-macrophage colony stimulating factor ( GM-CSF ) , M-CSF , and . Regulation IL1B IL3 2112081 133043 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL31 1387585 196260 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL31 2112081 133031 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL32 1387585 196257 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL32 2112081 133028 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL33 1387585 196256 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL33 2112081 133027 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL34 1387585 196261 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL34 2112081 133032 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL37 1387585 196255 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL37 2112081 133026 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL4 10088668 599960 and interleukin-10 *regulate* [IL1-beta] induced mouse primary astrocyte activation : a comparative study . Regulation IL1B IL4 11477201 841987 thus , to further clarify the differences of monocyte function and differentiation between neonates and adults , we investigated their CD14 ( + ) CD4 ( + ) and CD14 ( + ) CD16 ( + ) monocyte subpopulations , production of [IL-1beta] and tumor necrosis factor-alpha induced by lipopolysaccharide , and their CD14 and CD1a phenotypic changes in *response* to and granulocyte-macrophage colony stimulating factor . Regulation IL1B IL4 11491045 845683 Inhibitory *effect* of on the production of [IL-1 beta] and TNF-alpha by gastric mononuclear cells of Helicobacter pylori infected patients . Regulation IL1B IL4 1387585 196273 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL4 2112081 133044 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL4 2129394 150640 Cytokine gene expression in atopics : *effect* of on [IL-1 beta] and IL-6 mRNA levels . Regulation IL1B IL4 7540642 310127 Seven-day cultured monocytes/macrophages showed ( 1 ) diminished TNF-alpha production in response to IL-10 but not IL-4 ( 2 ) , diminished [IL-1 beta] production in *response* to both and IL-10 , and compared with fresh monocytes ( 3 ) , diminished CD14 expression in response to IL-4 , and ( 4 ) a lesser increase in CD23 expression in response to IL-4 . Regulation IL1B IL4 7628587 316509 In this study , we investigated the *effect* of on IL-1 alpha and [IL-1 beta] production by ATL cells in vitro . Regulation IL1B IL4 8260535 238832 In addition , IFN-gamma totally overcame the negative *effect* of ( 100 pM ) on [IL-1 beta] protein synthesis . Regulation IL1B IL4 8484092 218922 The *effects* of recombinant human and the glucocorticoid , dexamethasone , on tumor necrosis factor alpha (TNF alpha) and [interleukin-1 beta (IL-1 beta)] levels in cultures of rheumatoid and osteoarthritic synovial tissue were studied . Regulation IL1B IL4 8894439 392367 The *effect* of and IL-13 on IL-6 and [IL-1 beta] production by human embryonic microglial cells and human peripheral blood monocyte cells ( PBMC ) was compared . Regulation IL1B IL4 8964392 366112 IL-4 levels were measured by enzyme linked immunosorbent assay in cultures of control and inflammatory bowel disease LPMCs , and the *effect* of on LPMC proliferation and interaction with IL-2 , [IL-1 beta] , lipopolysaccharide , bacterial antigens , superantigen , and antibodies to various T-cell receptors was investigated . Regulation IL1B IL5 1387585 196274 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL5 2112081 133045 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL6 12096891 961158 The present study tested whether prior exposure to inescapable tailshock ( IS ) alters the [interleukin (IL)-1beta] , tumor necrosis factor (TNF)-alpha , or *response* to an injection of bacterial endotoxin ( lipopolysaccharide ; Regulation IL1B IL6 1335554 206053 Thus , we evaluated the *effect* of on ACTH secretion and its interaction with [IL-1 beta] . Regulation IL1B IL6 1387585 196275 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL6 1393463 198825 The systemic [IL-1 beta] and *response* to surgical trauma increased with the severity of the surgical insult . Regulation IL1B IL6 1541815 180863 No detectable circulating TNF-alpha , [IL-1 beta] , or *response* was induced by either IL-8 administration regimen . Regulation IL1B IL6 2112081 133046 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL6 2809510 121412 Although bacterial endotoxin/lipopolysaccharide is a potent stimulus for the synthesis and release of IL-1 and IL-6 in vitro , specific neutralization of cachectin/TNF in vivo with mAb pretreatment significantly attenuated both the [IL-1 beta] and the *responses* despite fulminant overwhelming bacteremia . Regulation IL1B IL6 7850809 294326 Collectively , additional factor ( s ) besides IL-1Ra and [IL-1 beta] may *control* and some other cachexigenic factor production , thereby causing cachexia in this model . Regulation IL1B IL6 7945622 276565 Neonatal tumor necrosis factor , interleukin-1 alpha , [interleukin-1 beta] , and *response* to infection . Regulation IL1B IL6 9878816 583805 The *role* of in the activation of the hypothalamo-pituitary-adrenocortical axis and brain indoleamines by endotoxin and [interleukin-1 beta] . Regulation IL1B IL6ST 10080875 597471 *Involvement* of NF-kappaB p50/p65 in activation of the human [pro-interleukin-1beta] gene at two subregions of the upstream enhancer element . Regulation IL1B IL7 1387585 196276 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL7 2112081 133047 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL8 1387585 196277 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL8 2112081 133048 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B IL8 9605181 507581 These results provide evidence that and TNFalpha were *responsible* for the production of [IL-1beta] and IL-1Ra , and that IL-1beta was responsible for the second phase of IL-1beta and IL-8 production . Regulation IL1B IL9 1387585 196278 Specific inhibition of [interleukin 1 beta] gene expression by an antisense oligonucleotide : obligatory *role* of 1 in the generation of lymphokine activated killer cells . Regulation IL1B IL9 2112081 133049 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant , tumor necrosis factor , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B INHBA 9712365 527257 *regulates* the production of mature [interleukin-1beta] and interleukin-1 receptor antagonist in human monocytic cells . Regulation IL1B INHBA 9712365 527264 Northern blot analysis revealed that activin A had no effect on mRNA accumulation of IL-1beta and IL-1ra , indicating that *regulates* [IL-1beta] and IL-1ra production at a posttranscriptional level . Regulation IL1B IRAK1 11583588 865687 To study the *role* of in [IL-1 beta] signalling , we have generated a set of IRAK-1 variants that express distinct domains of IRAK-1 either alone or in combination and have examined their effects on an NF-kappa B-responsive reporter in HeLa cells . Regulation IL1B IRAK1 19342688 2056855 The *role* and relative contribution of MyD88 , , and TRAF6 adaptor proteins in [IL-1beta] regulation of aggrecanase-1 ( ADAMTS-4 ) is unknown . Regulation IL1B IRAK4 11277982 798052 In summary , we demonstrate that [IL-1beta] induction of NPY expression in astrocytes is species- and cytokine-specific and that is *involved* . Regulation IL1B ITGB2 1399006 199412 These results suggest that may *play* an important role in the secretion of TNF-alpha and [IL-1 beta] by TSST-1 stimulated human monocytes , likely by promoting cell-cell adhesion between monocytes and lymphocytes . Regulation IL1B JAK2 12686512 1106069 Finally , we show that is *involved* in the production of [IL-1beta] and IL-6 . Regulation IL1B JUN 11028561 739592 These results suggest that the AP-1 family of transcription factors is activated by [IL-1beta] in human enterocytes and that may at least in part *regulate* IL-6 production in these cells . Regulation IL1B JUN 11052809 743452 Transcriptional regulation of the human [interleukin 1beta] gene by fibronectin : *role* of protein kinase C and . Regulation IL1B JUN 11274229 797588 These data suggested that ( 1 ) constitutive and [IL-1beta-inducible] expression of MCP-1 was differently *regulated* by and NF-kappaB and ( 2 ) t-RA inhibited selectively the constitutive expression of MCP-1 via intervention in the AP-1 pathway . Regulation IL1B JUN 11930628 894643 Enhancement of activity of NF kappa B and may positively *regulate* the production of IL-8 and [IL-1 beta] in the airflow obstruction . Regulation IL1B JUN 11930749 894649 [IL-1 beta] induced cytotoxicity via activating JNK pathway and and the simultaneous activation of p38 kinase pathway negatively *regulated* this process . Regulation IL1B JUN 8386622 217821 We have now examined the *role* of in the regulation of the [IL-1 beta] gene expression by PKC and cAMP in THP-1 cells . Regulation IL1B LALBA 9220583 442582 However , exhibited an enhancing *effect* on [IL-1 beta] production . Regulation IL1B LAMB1 15793118 1386907 and ABLC decreased or did not *affect* [IL-1beta] and TNF-alpha , whereas ABLC additionally decreased MIP-1beta . Regulation IL1B LAMB2 15793118 1386908 and ABLC decreased or did not *affect* [IL-1beta] and TNF-alpha , whereas ABLC additionally decreased MIP-1beta . Regulation IL1B LAMB3 15793118 1386909 and ABLC decreased or did not *affect* [IL-1beta] and TNF-alpha , whereas ABLC additionally decreased MIP-1beta . Regulation IL1B LAMB4 15793118 1386910 and ABLC decreased or did not *affect* [IL-1beta] and TNF-alpha , whereas ABLC additionally decreased MIP-1beta . Regulation IL1B LEO1 1710753 158272 The magnitude of the *effects* of on [IL-1 beta] mRNA levels matched closely the effects seen at the level of protein synthesis , suggesting that the effects of PAF on IL-1 beta release may result largely from its effects on IL-1 beta mRNA levels . Regulation IL1B LEO1 2293896 127477 To assess the *effect* of on [IL-1 beta] synthesis , THP-1 cell pellet proteins were separated by SDS-PAGE , blotted , and immunostained to detect IL-1 beta . Regulation IL1B LEP 12213309 985346 *regulates* [interleukin-1beta] expression in the brain via the STAT3 independent mechanisms . Regulation IL1B LEP 15304373 1322291 Physiological *regulation* of hypothalamic [IL-1beta] gene expression by and glucocorticoids : implications for energy homeostasis . Regulation IL1B LEP 17419800 1766233 These results confirm our earlier observations in vivo and demonstrate that microglia are an important source of [IL-1beta] in the brain in *response* to . Regulation IL1B LGALS3 18825751 1981599 Furthermore , deficiency in macrophages may be *responsible* for the higher [IL-1beta] serum levels detected in infected gal3 ( -/- ) mice . Regulation IL1B LTA 19124206 2060813 Infection of pigs with PRRSV also resulted in an increased secretion of [IL-1beta] by AMs in *response* to stimulation , and IL-6 by PBMCs in response to lipopolysaccharide (LPS) and LTA stimulation . Regulation IL1B LTB 11908571 923608 The effect of antiinflammatory cytokines rhIL-4 , IL-10 , and IL-13 on basal and *dependent* stimulation of [IL-1beta/TNF-alpha] synthesis was studied under titration conditions . Regulation IL1B LTB 11908571 923616 The antiinflammatory cytokine IL-4 blocked *dependent* stimulation of [IL-1beta] and TNF-alpha synthesis . Regulation IL1B LTB 8016588 262664 We examined the *role* of in the production of [Interleukin-1 beta (IL-1 beta)] by rheumatoid synovial cells since a substantial amount of LTB4 has been detected in the synovial fluid from patients with rheumatoid arthritis . Regulation IL1B LTB 8016588 262666 These results suggest that in cooperation with certain cytokines might *play* a pivotal role in the [IL-1 beta] production by rheumatoid synovial cells in vivo . Regulation IL1B LTB 8384162 214729 The CF mediator levels showed increased levels of PGE2 and TxB2 at the ligated sites , as compared with the spontaneous sites , with no significant contralateral differences in the [IL-1 beta] or *responses* . Regulation IL1B MALT1 12716016 1083713 The *effect* of on the brain levels of tumor necrosis factor alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] in Venezuelan equine encephalomyelitis ( VEE ) virus infection was determined . Regulation IL1B MAP2K1 11527379 853351 Differential *regulation* of [IL-1beta] and TNF-alpha RNA expression by inhibitor after focal cerebral ischemia in mice . Regulation IL1B MAP3K8 19689369 2126542 kinase activation *plays* an integral role in the production of pro-inflammatory cytokines such as TNF and [IL-1beta] in this immune cell type . Regulation IL1B MAPK1 10228013 610618 The *role* of p38 in [IL-1 beta] transcription . Regulation IL1B MAPK1 10228013 610657 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Regulation IL1B MAPK1 10228013 610711 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Regulation IL1B MAPK1 10845922 700749 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Regulation IL1B MAPK1 11728947 884792 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Regulation IL1B MAPK1 12676746 1076867 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Regulation IL1B MAPK1 12734378 1087367 Our results indicate that A beta induced expression of cytokines ( TNF-alpha and [IL-1 beta] ) and chemokines ( MCP-1 , IL-8 , and MIP-1 beta ) in THP-1 monocytes *involves* activation of and downstream activation of Egr-1 . Regulation IL1B MAPK1 15001568 1236939 Angiotensin II differentially *regulates* [interleukin-1-beta-inducible] NO synthase (iNOS) and vascular cell adhesion molecule-1 ( VCAM-1 ) expression : role of p38 . Regulation IL1B MAPK1 15195698 1260179 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Regulation IL1B MAPK1 17084586 1709006 These data suggest that p38 and ERK 1/2 *play* an important role in induction of [IL-1beta] expression in J774A.1 macrophages exposed to test platinum compounds . Regulation IL1B MAPK10 10228013 610619 The *role* of p38 in [IL-1 beta] transcription . Regulation IL1B MAPK10 10228013 610658 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Regulation IL1B MAPK10 10228013 610712 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Regulation IL1B MAPK10 10845922 700750 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Regulation IL1B MAPK10 11728947 884793 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Regulation IL1B MAPK10 12676746 1076868 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Regulation IL1B MAPK10 15001568 1236940 Angiotensin II differentially *regulates* [interleukin-1-beta-inducible] NO synthase (iNOS) and vascular cell adhesion molecule-1 ( VCAM-1 ) expression : role of p38 . Regulation IL1B MAPK10 15195698 1260180 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Regulation IL1B MAPK10 17084586 1709007 These data suggest that p38 and ERK 1/2 *play* an important role in induction of [IL-1beta] expression in J774A.1 macrophages exposed to test platinum compounds . Regulation IL1B MAPK11 10228013 610620 The *role* of p38 in [IL-1 beta] transcription . Regulation IL1B MAPK11 10228013 610659 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Regulation IL1B MAPK11 10228013 610713 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Regulation IL1B MAPK11 10845922 700751 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Regulation IL1B MAPK11 11728947 884794 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Regulation IL1B MAPK11 12676746 1076869 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Regulation IL1B MAPK11 15001568 1236941 Angiotensin II differentially *regulates* [interleukin-1-beta-inducible] NO synthase (iNOS) and vascular cell adhesion molecule-1 ( VCAM-1 ) expression : role of p38 . Regulation IL1B MAPK11 15195698 1260181 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Regulation IL1B MAPK11 17084586 1709008 These data suggest that p38 and ERK 1/2 *play* an important role in induction of [IL-1beta] expression in J774A.1 macrophages exposed to test platinum compounds . Regulation IL1B MAPK12 10228013 610621 The *role* of p38 in [IL-1 beta] transcription . Regulation IL1B MAPK12 10228013 610660 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Regulation IL1B MAPK12 10228013 610714 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Regulation IL1B MAPK12 10845922 700752 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Regulation IL1B MAPK12 11728947 884795 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Regulation IL1B MAPK12 12676746 1076870 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Regulation IL1B MAPK12 15001568 1236942 Angiotensin II differentially *regulates* [interleukin-1-beta-inducible] NO synthase (iNOS) and vascular cell adhesion molecule-1 ( VCAM-1 ) expression : role of p38 . Regulation IL1B MAPK12 15195698 1260182 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Regulation IL1B MAPK12 17084586 1709009 These data suggest that p38 and ERK 1/2 *play* an important role in induction of [IL-1beta] expression in J774A.1 macrophages exposed to test platinum compounds . Regulation IL1B MAPK13 10228013 610622 The *role* of p38 in [IL-1 beta] transcription . Regulation IL1B MAPK13 10228013 610661 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Regulation IL1B MAPK13 10228013 610715 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Regulation IL1B MAPK13 10845922 700753 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Regulation IL1B MAPK13 11728947 884796 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Regulation IL1B MAPK13 12676746 1076871 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Regulation IL1B MAPK13 15001568 1236943 Angiotensin II differentially *regulates* [interleukin-1-beta-inducible] NO synthase (iNOS) and vascular cell adhesion molecule-1 ( VCAM-1 ) expression : role of p38 . Regulation IL1B MAPK13 15195698 1260183 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Regulation IL1B MAPK13 17084586 1709010 These data suggest that p38 and ERK 1/2 *play* an important role in induction of [IL-1beta] expression in J774A.1 macrophages exposed to test platinum compounds . Regulation IL1B MAPK14 10228013 610623 The *role* of p38 in [IL-1 beta] transcription . Regulation IL1B MAPK14 10228013 610662 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Regulation IL1B MAPK14 10228013 610716 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Regulation IL1B MAPK14 10845922 700754 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Regulation IL1B MAPK14 11728947 884797 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Regulation IL1B MAPK14 12676746 1076872 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Regulation IL1B MAPK14 15001568 1236944 Angiotensin II differentially *regulates* [interleukin-1-beta-inducible] NO synthase (iNOS) and vascular cell adhesion molecule-1 ( VCAM-1 ) expression : role of p38 . Regulation IL1B MAPK14 15195698 1260184 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Regulation IL1B MAPK14 17084586 1709011 These data suggest that p38 and ERK 1/2 *play* an important role in induction of [IL-1beta] expression in J774A.1 macrophages exposed to test platinum compounds . Regulation IL1B MAPK15 10228013 610617 The *role* of p38 in [IL-1 beta] transcription . Regulation IL1B MAPK15 10228013 610656 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Regulation IL1B MAPK15 10228013 610710 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Regulation IL1B MAPK15 10845922 700748 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Regulation IL1B MAPK15 11728947 884791 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Regulation IL1B MAPK15 12676746 1076866 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Regulation IL1B MAPK15 15001568 1236938 Angiotensin II differentially *regulates* [interleukin-1-beta-inducible] NO synthase (iNOS) and vascular cell adhesion molecule-1 ( VCAM-1 ) expression : role of p38 . Regulation IL1B MAPK15 15195698 1260178 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Regulation IL1B MAPK15 17084586 1709005 These data suggest that p38 and ERK 1/2 *play* an important role in induction of [IL-1beta] expression in J774A.1 macrophages exposed to test platinum compounds . Regulation IL1B MAPK3 10228013 610624 The *role* of p38 in [IL-1 beta] transcription . Regulation IL1B MAPK3 10228013 610663 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Regulation IL1B MAPK3 10228013 610717 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Regulation IL1B MAPK3 10845922 700755 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Regulation IL1B MAPK3 11728947 884798 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Regulation IL1B MAPK3 12676746 1076873 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Regulation IL1B MAPK3 12734378 1087368 Our results indicate that A beta induced expression of cytokines ( TNF-alpha and [IL-1 beta] ) and chemokines ( MCP-1 , IL-8 , and MIP-1 beta ) in THP-1 monocytes *involves* activation of and downstream activation of Egr-1 . Regulation IL1B MAPK3 14960485 1242927 These data indicate that , in normal human cytotrophoblast cells , [IL-1 beta] induces HIF- 1 alpha mediated VEGF secretion and that IL-1 beta stimulated activation may be *involved* in this process . Regulation IL1B MAPK3 15001568 1236945 Angiotensin II differentially *regulates* [interleukin-1-beta-inducible] NO synthase (iNOS) and vascular cell adhesion molecule-1 ( VCAM-1 ) expression : role of p38 . Regulation IL1B MAPK3 15195698 1260185 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Regulation IL1B MAPK3 17084586 1709012 These data suggest that p38 and ERK 1/2 *play* an important role in induction of [IL-1beta] expression in J774A.1 macrophages exposed to test platinum compounds . Regulation IL1B MAPK3 9624172 511386 Differential *roles* of and p38 ( MAPK ) in [interleukin-1beta-] and tumor necrosis factor-alpha induced low density lipoprotein receptor expression in HepG2 cells . Regulation IL1B MAPK4 10228013 610625 The *role* of p38 in [IL-1 beta] transcription . Regulation IL1B MAPK4 10228013 610664 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Regulation IL1B MAPK4 10228013 610718 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Regulation IL1B MAPK4 10845922 700756 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Regulation IL1B MAPK4 11728947 884799 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Regulation IL1B MAPK4 12676746 1076874 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Regulation IL1B MAPK4 15001568 1236946 Angiotensin II differentially *regulates* [interleukin-1-beta-inducible] NO synthase (iNOS) and vascular cell adhesion molecule-1 ( VCAM-1 ) expression : role of p38 . Regulation IL1B MAPK4 15195698 1260186 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Regulation IL1B MAPK4 17084586 1709013 These data suggest that p38 and ERK 1/2 *play* an important role in induction of [IL-1beta] expression in J774A.1 macrophages exposed to test platinum compounds . Regulation IL1B MAPK6 10228013 610626 The *role* of p38 in [IL-1 beta] transcription . Regulation IL1B MAPK6 10228013 610665 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Regulation IL1B MAPK6 10228013 610719 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Regulation IL1B MAPK6 10845922 700757 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Regulation IL1B MAPK6 11728947 884800 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Regulation IL1B MAPK6 12676746 1076875 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Regulation IL1B MAPK6 15001568 1236947 Angiotensin II differentially *regulates* [interleukin-1-beta-inducible] NO synthase (iNOS) and vascular cell adhesion molecule-1 ( VCAM-1 ) expression : role of p38 . Regulation IL1B MAPK6 15195698 1260187 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Regulation IL1B MAPK6 17084586 1709014 These data suggest that p38 and ERK 1/2 *play* an important role in induction of [IL-1beta] expression in J774A.1 macrophages exposed to test platinum compounds . Regulation IL1B MAPK7 10228013 610627 The *role* of p38 in [IL-1 beta] transcription . Regulation IL1B MAPK7 10228013 610666 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Regulation IL1B MAPK7 10228013 610720 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Regulation IL1B MAPK7 10845922 700758 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Regulation IL1B MAPK7 11728947 884801 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Regulation IL1B MAPK7 12676746 1076876 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Regulation IL1B MAPK7 15001568 1236948 Angiotensin II differentially *regulates* [interleukin-1-beta-inducible] NO synthase (iNOS) and vascular cell adhesion molecule-1 ( VCAM-1 ) expression : role of p38 . Regulation IL1B MAPK7 15195698 1260188 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Regulation IL1B MAPK7 17084586 1709015 These data suggest that p38 and ERK 1/2 *play* an important role in induction of [IL-1beta] expression in J774A.1 macrophages exposed to test platinum compounds . Regulation IL1B MAPK8 10228013 610628 The *role* of p38 in [IL-1 beta] transcription . Regulation IL1B MAPK8 10228013 610667 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Regulation IL1B MAPK8 10228013 610721 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Regulation IL1B MAPK8 10845922 700759 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Regulation IL1B MAPK8 11728947 884802 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Regulation IL1B MAPK8 12676746 1076877 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Regulation IL1B MAPK8 15001568 1236949 Angiotensin II differentially *regulates* [interleukin-1-beta-inducible] NO synthase (iNOS) and vascular cell adhesion molecule-1 ( VCAM-1 ) expression : role of p38 . Regulation IL1B MAPK8 15195698 1260189 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Regulation IL1B MAPK8 17084586 1709016 These data suggest that p38 and ERK 1/2 *play* an important role in induction of [IL-1beta] expression in J774A.1 macrophages exposed to test platinum compounds . Regulation IL1B MAPK9 10228013 610629 The *role* of p38 in [IL-1 beta] transcription . Regulation IL1B MAPK9 10228013 610668 In this study , we examined the *role* of p38 in the regulation of the [IL-1beta] cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580 . Regulation IL1B MAPK9 10228013 610722 Overall , the results demonstrate , for the first time , a *role* for p38 in [IL-1beta] transcription by acting through C/EBP/NFIL-6 transcription factors . Regulation IL1B MAPK9 10845922 700760 On the other hand , inhibition of p38 by SB203580 indicates that this is *involved* in the control of [IL-1beta] production at both transcriptional and translational levels . Regulation IL1B MAPK9 11728947 884803 p38 is *involved* in the production and signal transduction of [interleukin-1beta (IL-1beta)] , tumor necrosis factor-alpha , and chemokines in vitro . Regulation IL1B MAPK9 12676746 1076878 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that signaling and NF-kappaB activation are *involved* in IL-1beta induced IL-6 production . Regulation IL1B MAPK9 15001568 1236950 Angiotensin II differentially *regulates* [interleukin-1-beta-inducible] NO synthase (iNOS) and vascular cell adhesion molecule-1 ( VCAM-1 ) expression : role of p38 . Regulation IL1B MAPK9 15195698 1260190 p38 *regulates* [IL-1beta] induced IL-6 expression through mRNA stability in osteoblasts . Regulation IL1B MAPK9 17084586 1709017 These data suggest that p38 and ERK 1/2 *play* an important role in induction of [IL-1beta] expression in J774A.1 macrophages exposed to test platinum compounds . Regulation IL1B MCM2 19131350 2079091 Fibronectin and [IL-1beta] levels were enhanced proportionately between the sexes in *response* to stimulation , whilst the increase in TNFalpha levels was greater in MCM stimulated female cells . Regulation IL1B MCM3 19131350 2079092 Fibronectin and [IL-1beta] levels were enhanced proportionately between the sexes in *response* to stimulation , whilst the increase in TNFalpha levels was greater in MCM stimulated female cells . Regulation IL1B MCM4 19131350 2079093 Fibronectin and [IL-1beta] levels were enhanced proportionately between the sexes in *response* to stimulation , whilst the increase in TNFalpha levels was greater in MCM stimulated female cells . Regulation IL1B MCM5 19131350 2079094 Fibronectin and [IL-1beta] levels were enhanced proportionately between the sexes in *response* to stimulation , whilst the increase in TNFalpha levels was greater in MCM stimulated female cells . Regulation IL1B MCM6 19131350 2079095 Fibronectin and [IL-1beta] levels were enhanced proportionately between the sexes in *response* to stimulation , whilst the increase in TNFalpha levels was greater in MCM stimulated female cells . Regulation IL1B MCM7 19131350 2079096 Fibronectin and [IL-1beta] levels were enhanced proportionately between the sexes in *response* to stimulation , whilst the increase in TNFalpha levels was greater in MCM stimulated female cells . Regulation IL1B MSH2 1655471 166232 Additionally , the *effects* of alpha on the specific binding of [IL-1 beta] to B- and T-cells have been investigated to further clarify its inhibitory activities . Regulation IL1B MSH2 8298992 240968 The same animal model has been used to investigate the regulatory *effect* of alpha , an immunosuppressive neurohormone , on [IL-1 beta] stimulated CRH and AVP secretion . Regulation IL1B MSH3 1655471 166233 Additionally , the *effects* of alpha on the specific binding of [IL-1 beta] to B- and T-cells have been investigated to further clarify its inhibitory activities . Regulation IL1B MSH3 8298992 240969 The same animal model has been used to investigate the regulatory *effect* of alpha , an immunosuppressive neurohormone , on [IL-1 beta] stimulated CRH and AVP secretion . Regulation IL1B MSH4 1655471 166234 Additionally , the *effects* of alpha on the specific binding of [IL-1 beta] to B- and T-cells have been investigated to further clarify its inhibitory activities . Regulation IL1B MSH4 8298992 240970 The same animal model has been used to investigate the regulatory *effect* of alpha , an immunosuppressive neurohormone , on [IL-1 beta] stimulated CRH and AVP secretion . Regulation IL1B MSH5 1655471 166235 Additionally , the *effects* of alpha on the specific binding of [IL-1 beta] to B- and T-cells have been investigated to further clarify its inhibitory activities . Regulation IL1B MSH5 8298992 240971 The same animal model has been used to investigate the regulatory *effect* of alpha , an immunosuppressive neurohormone , on [IL-1 beta] stimulated CRH and AVP secretion . Regulation IL1B MSH6 1655471 166236 Additionally , the *effects* of alpha on the specific binding of [IL-1 beta] to B- and T-cells have been investigated to further clarify its inhibitory activities . Regulation IL1B MSH6 8298992 240972 The same animal model has been used to investigate the regulatory *effect* of alpha , an immunosuppressive neurohormone , on [IL-1 beta] stimulated CRH and AVP secretion . Regulation IL1B MT-CO2 15529314 1355146 On the other hand , and Cr3+ ions had a weak stimulatory effect or no *effect* on [IL-1beta] and IL-6 , respectively , in both cultured and suspension cells . Regulation IL1B MTX1 15385641 1300147 These results indicate that the inflammatory macrophage can assemble the necessary signaling components to initiate both regulated and lytic release of [IL-1beta] in *response* to . Regulation IL1B MYD88 17032168 1630781 These studies support the hypothesis that the expression of IL-1beta requires both the *dependent* induction of IL-1beta mRNA and [pro-IL-1beta] as well as the MyD88 independent , Stat1 mediated processing of that gene product into active cytokine . Regulation IL1B MYD88 19342688 2056856 The *role* and relative contribution of , IRAK1 , and TRAF6 adaptor proteins in [IL-1beta] regulation of aggrecanase-1 ( ADAMTS-4 ) is unknown . Regulation IL1B NCL 19060367 2000034 [ *Role* of cell-surface in lipopolysaccharide stimulated expression and secretion of TNF-alpha and [IL-1beta] ] . Regulation IL1B NCL 19060367 2000040 To explore the *role* of cell-surface in lipopolysaccharide (LPS) stimulated expression and secretion of TNF-alpha and [IL-1beta] in human THP-1 monocytes . Regulation IL1B NELFCD 11729116 884819 IL-18 plays a pivotal role in *responses* , but its proinflammatory activities extend beyond Th1 cells , including macrophages and production of tumor necrosis factor (TNF) alpha and [IL-1beta] . Regulation IL1B NELFCD 20153259 2248520 Using PBMC from healthy individuals , we show that monocytes differentiated with IL-15 ( IL15-DC ) produced [IL-1beta] , IL-6 , IL-15 , IL-23 , TNFalpha and CCL20 in *response* to pepsin-trypsin digested gliadin (PTG) and activated contact dependent Th17 and responses from autologous CD4 ( + ) T cells . Regulation IL1B NFKB1 10080875 597472 *Involvement* of p50/p65 heterodimer in activation of the human [pro-interleukin-1beta] gene at two subregions of the upstream enhancer element . Regulation IL1B NFKB1 10760471 683532 The results show that the [IL-1beta] induced expression of group V sPLA ( 2 ) mRNA was time *dependent* and , similar to that of group IIA sPLA ( 2 ) mRNA , involves activation of . Regulation IL1B NFKB1 11274229 797589 These data suggested that ( 1 ) constitutive and [IL-1beta-inducible] expression of MCP-1 was differently *regulated* by AP-1 and and ( 2 ) t-RA inhibited selectively the constitutive expression of MCP-1 via intervention in the AP-1 pathway . Regulation IL1B NFKB1 11930628 894644 Enhancement of activity of and AP-1 may positively *regulate* the production of IL-8 and [IL-1 beta] in the airflow obstruction . Regulation IL1B NFKB1 12021045 942767 In this study , we investigated the possible *role* of the in [IL-1beta] signaling , leading to the expression of COX-2 in human amnion cell culture . Regulation IL1B NFKB1 12676746 1076879 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that mitogen activated protein (MAP) kinase signaling and activation are *involved* in IL-1beta induced IL-6 production . Regulation IL1B NFKB1 12920043 1174004 Inhibiting did not *affect* either [IL-1beta] secretion or phenotypic maturation but rather sensitized DCs to Fas mediated apoptosis . Regulation IL1B NFKB1 12946102 1136781 *Involvement* of the transcription factor in expression of [IL-1beta1] and IL-1beta2 was demonstrated . Regulation IL1B NFKB1 15063239 1230848 *plays* a central role in the regulation of [IL-1beta] and subsequent IL-1beta dependent inflammatory processes . Regulation IL1B NFKB1 16580131 1562452 Taken together , these results suggest that the induction of [IL-1beta] and TNFalpha in endotoxin stimulated microglia is differentially *regulated* at the level of activation . Regulation IL1B NFKB1 19248089 2045030 Matrix metalloproteinase 13 was induced by [IL-1beta] in a *dependent* manner . Regulation IL1B NFKB1 19454703 2084580 In direct correlation with the increased viral internalization , antiviral Abs amplified the innate immune response to adenovirus as determined by the expression of *dependent* genes , type I IFNs , and caspase dependent [IL-1beta] maturation . Regulation IL1B NFKB1 8021507 263080 *regulates* [IL-1 beta] transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site . Regulation IL1B NFKB1 8144314 242476 Therefore , we investigated whether cyclic AMP , protein kinase A and are *involved* in the induction of [IL-1 beta] release by human peripheral blood monocyte derived macrophages ( HPBM ) stimulated with a specific IL-1 beta inducer , 9-hydroxyoctadecadienoic acid ( 9-HODE ) . Regulation IL1B NFKB1 9079634 420550 *Role* of in tumor necrosis factor-alpha and [interleukin-1beta] regulation . Regulation IL1B NFKB1 9510209 491889 The *role* of activation in BK-induced [IL-1beta] synthesis was demonstrated by the ability of BK to stimulate increased chloramphenicol acetyltransferase (CAT) activity in A549 cells transfected with a reporter plasmid containing three kappaB enhancers from the IL-1beta gene , while deletion of the kappaB enhancer sequences eliminated BK-stimulated CAT activity . Regulation IL1B NFKBIZ 16622025 1551555 [IL-1beta-specific] up-regulation of neutrophil gelatinase associated lipocalin is *controlled* by . Regulation IL1B NGF 8977255 403205 The stimulating *effect* of on phagocytosis , parasite killing , and [interleukin-1beta (IL-1beta)] production of murine peritoneal macrophages was assessed . Regulation IL1B NLN 12108020 963139 The production of TNF-alpha and [IL-1 beta] was not *affected* by and GLP at the concentrations which significantly inhibited the proliferative activity and T cell derived cytokine production . Regulation IL1B NLRC4 19120480 2019405 In this review , we focus on the role of Nod1 and Nod2 in host defense and in particular discuss recent finding regarding the *role* of , Nlpr1 , and Nlrp3 inflammasomes in caspase-1 activation and subsequent release of proinflammatory cytokines such as [interleukin-1 beta] . Regulation IL1B NLRP3 16407888 1527491 Furthermore , we show that Toll-like receptors and *control* the secretion of [IL-1beta] and IL-18 through different intracellular pathways . Regulation IL1B NLRP3 17008311 1647459 Stimulation of macrophages with dsRNA , viral RNA , or its analog poly ( I:C ) induced the secretion of [IL-1beta] and IL-18 in a *dependent* manner . Regulation IL1B NLRP3 19319132 2073574 Production of mature [IL-1beta] is *dependent* on a caspase-1 activating protein complex called the NALP3 inflammasome , composed of , ASC , and CARD8 . Regulation IL1B NLRP3 19454352 2084491 The known fungal pattern recognition receptors TLR2 and Dectin-1 regulate IL-1beta gene transcription , whereas the containing proinflammatory multiprotein complex , the NLRP3 inflammasome , *controls* caspase-1 mediated cleavage of [pro-IL-1beta] . Regulation IL1B NMU 18336945 1898209 Real-time PCR based experiments indicated that did not *affect* the mRNA level of [IL-1beta] or IL-6 increased by LPS , whereas it increased that of brain derived neurotrophic factor (BDNF) in the hippocampus . Regulation IL1B NOD1 12459189 1021713 Our data indicate that can *regulate* [IL-1beta] secretion , implying that Nod1 may play a role in inflammatory responses to bacterial LPS . Regulation IL1B NOD1 18487086 1921746 The proteins mediate NF-kappaB activation , whereas Pyrin molecules such as NALP3 *regulate* [IL-1beta] and IL-18 production . Regulation IL1B NOD2 18157816 1847600 Although it is known that NOD2 mediates cytokine responses to muramyl dipeptide ( MDP ) , it is yet unclear whether NOD2 stimulation mediates only transcription of pro-IL-1beta mRNA , or whether is also *involved* in the activation of caspase-1 and release of active [IL-1beta] . Regulation IL1B NOD2 18487086 1921747 The proteins mediate NF-kappaB activation , whereas Pyrin molecules such as NALP3 *regulate* [IL-1beta] and IL-18 production . Regulation IL1B NOD2 19180500 2033127 Furthermore , functional studies demonstrate that caspase 1-mediated release of [IL-1beta] also *involves* . Regulation IL1B NOS1 10374159 623057 These findings suggest a strong inhibitory effect of inhibitors and corticosteroids on aqueous levels of TNF-alpha and NO and no inhibitory *effect* on [IL-1 beta] and IL-6 levels after cataract surgery . Regulation IL1B NOS2 7534733 287761 mRNA degradation is rapid and it is not *affected* by [IL-1 beta] . Regulation IL1B NOS2 8879343 390742 Thus , [IL-1 beta] *controls* gene expression at the transcriptional level , and an intermediate labile protein , whose synthesis is inhibited by cycloheximide , is required for IL-1 beta stimulated induction of iNOS mRNA transcription in WKY cells but not in SHR . Regulation IL1B NOX1 14967724 1212169 Cilostazol ( 1 to 100 micromol/L ) significantly suppressed not only *dependent* superoxide production but also TNF-alpha and [interleukin-1beta] release and restored viability . Regulation IL1B NOX3 14967724 1212170 Cilostazol ( 1 to 100 micromol/L ) significantly suppressed not only *dependent* superoxide production but also TNF-alpha and [interleukin-1beta] release and restored viability . Regulation IL1B NOX4 14967724 1212171 Cilostazol ( 1 to 100 micromol/L ) significantly suppressed not only *dependent* superoxide production but also TNF-alpha and [interleukin-1beta] release and restored viability . Regulation IL1B NOX5 14967724 1212168 Cilostazol ( 1 to 100 micromol/L ) significantly suppressed not only *dependent* superoxide production but also TNF-alpha and [interleukin-1beta] release and restored viability . Regulation IL1B NPS 7477764 322861 The aim of this study was to evaluate the *role* of hypothalamic ( thyreoliberin [ TRH ] , somatostatin [ SRIF ] , and gonadoliberin [ LH-RH ] ) on the secretion of [interleukin-1 beta (IL-1 beta)] and interleukin-6 (IL-6) from lipopolysaccharide (LPS) activated human peripheral blood monocytes ( PM ) cultured in vitro . Regulation IL1B NPS 8765329 378676 *Effects* of substance P and selected other on the synthesis of [interleukin-1 beta] and interleukin-6 in human monocytes : a re-examination . Regulation IL1B NPY 12873794 1114342 In the present study , we have investigated the in vitro *effect* of calcitonin related peptide ( CGRP ) , , substance P ( SP ) and vasoactive intestinal peptide (VIP) at concentrations of 10 ( -8 ) , 10 ( -9 ) and 10 ( -10 ) M on the production of different proinflammatory cytokines or chemokines such as [IL-1beta] , IL-6 and TNFalpha by peripheral whole blood cells from patients with rheumatoid arthritis , as well as from osteoarthritis patients studied as a control group without immunoinflammatory background . Regulation IL1B NPY 8982099 403801 In the present study , we have investigated the *effect* in vitro of gastrin releasing peptide ( GRP , 10 ( -10 ) M ) , ( NPY , 10 ( -10 ) M ) , somatostatin ( 10 ( -10 ) M ) and vasoactive intestinal peptide ( VIP , 10 ( -9 ) M ) on the production of [IL-1 beta] , IL-6 and TNF alpha by peripheral whole blood cells from healthy young and old people . Regulation IL1B NR0B1 20442201 2307475 [IL-1beta] production in *response* to was studied in macrophages of wild-type , caspase-1 ( -/- ) , NLRP3 ( -/- ) , ASC ( -/- ) , cathepsin B ( -/- ) or cathepsin L ( -/- ) mice . Regulation IL1B NUP43 17395477 1728145 In the present study the quantitative *role* of and p38 in the production of TNF-alpha , [IL-1beta] and IL-12 by murine peritoneal macrophages , in vitro , on treatment with Concanavalin A ( ConA ) has been investigated . Regulation IL1B OPRM1 12002806 939861 Recent work in our laboratory has demonstrated that the is *involved* in [interleukin-1beta (IL-1beta)-] and in lipopolysaccharide (LPS) induced fevers . Regulation IL1B P2RX6 9053458 417244 Our data suggest that LPS dependent [IL-1 beta] release *involves* activation of this as it is inhibited by the selective P2Z/P2X7 blocker oxidized ATP and modulated by ATP hydrolyzing enzymes such as apyrase or hexokinase . Regulation IL1B P2RX7 12660148 1105964 Essential role for Ca2+ in *regulation* of [IL-1beta] secretion by nucleotide receptor in monocytes , macrophages , and HEK-293 cells . Regulation IL1B P2RX7 12759456 1091272 receptor *dependent* blebbing and the activation of Rho-effector kinases , caspases , and [IL-1 beta] release . Regulation IL1B P2RX7 12759456 1091274 To investigate the relationship between the *dependent* changes in plasma membrane organization and the release of [IL-1 beta] , we generated time-lapse movies of ATP stimulated BAC1 murine macrophages in conjunction with biochemical analyses of IL-1 beta release . Regulation IL1B P2RX7 16301672 1485268 This cytolysis was repressed by the cytoprotectant glycine , permitting dissociation of *regulated* secretion of mature [IL-1beta] from the lytic release of pro-IL-1beta . Regulation IL1B P2RX7 17121814 1686338 Blockade of pannexin-1 in macrophage endogenously expressing the ATP gated P2X7 receptor (P2X7R) blocks the initial dye uptake , but not the ionic current , and also blocks processing and release of [interleukin-1beta (IL-1beta)] in *response* to activation . Regulation IL1B P2RX7 17142754 1653734 Neither LPC induced [IL-1beta] release nor LPC stimulated intracellular Ca ( 2+ ) increases were *affected* by inhibition of ATP receptors with oxidized ATP . Regulation IL1B P2RX7 17491021 1761576 However , the *roles* of receptor and intracellular K ( + ) in [IL-1beta] secretion induced by bacterial infection remain unknown . Regulation IL1B P2RX7 17905568 1843823 In vitro and in vivo evidence for a *role* of the receptor in the release of [IL-1 beta] in the murine brain . Regulation IL1B P2RX7 18089587 1868635 [Interleukin-1 beta] secretion from cord blood mononuclear cells in vitro *involves* receptor activation . Regulation IL1B P2RX7 18523246 1922689 The , an ATP gated ion channel , *plays* essential roles in the release and maturation of [IL-1beta] in microglial cells in the brain . Regulation IL1B P2RX7 20071520 2194135 *dependent* release of [interleukin-1beta] and nociception in the spinal cord following lipopolysaccharide . Regulation IL1B P2RX7 20071520 2194136 Here we examine the *involvement* of the purinergic receptor in the release of [IL-1beta] following activation of Toll-like receptor-4 (TLR4) in the dorsal horn , which is associated with nociceptive behavior and microglial activation . Regulation IL1B P2RX7 20495003 2289011 TLR agonists induced receptor *dependent* [IL-1beta] release in both monocytes and macrophages ; Regulation IL1B PABPC1 19454352 2084496 The known fungal pattern recognition receptors TLR2 and Dectin-1 regulate IL-1beta gene transcription , whereas the NLRP3 containing proinflammatory , the NLRP3 inflammasome , *controls* caspase-1 mediated cleavage of [pro-IL-1beta] . Regulation IL1B PAF1 1710753 158270 The magnitude of the *effects* of on [IL-1 beta] mRNA levels matched closely the effects seen at the level of protein synthesis , suggesting that the effects of PAF on IL-1 beta release may result largely from its effects on IL-1 beta mRNA levels . Regulation IL1B PAF1 2293896 127475 To assess the *effect* of on [IL-1 beta] synthesis , THP-1 cell pellet proteins were separated by SDS-PAGE , blotted , and immunostained to detect IL-1 beta . Regulation IL1B PAIP1 19454352 2084493 The known fungal pattern recognition receptors TLR2 and Dectin-1 regulate IL-1beta gene transcription , whereas the NLRP3 containing proinflammatory , the NLRP3 inflammasome , *controls* caspase-1 mediated cleavage of [pro-IL-1beta] . Regulation IL1B PAK1 15561713 1367960 NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and mediated caspase-1 activation *play* essential roles in [interleukin-1beta] release from Helicobacter pylori lipopolysaccharide stimulated macrophages . Regulation IL1B PDE3A 18475493 209555 The *effect* of selective PDE-I ( vinpocetine ) , ( milrinone , CI-930 ) , PDE-IV ( rolipram , nitroquazone ) , and PDE-V ( zaprinast ) isozyme inhibitors on TNF-alpha and [IL-1beta] production from LPS stimulated human monocytes was investigated . Regulation IL1B PDE3B 18475493 209556 The *effect* of selective PDE-I ( vinpocetine ) , ( milrinone , CI-930 ) , PDE-IV ( rolipram , nitroquazone ) , and PDE-V ( zaprinast ) isozyme inhibitors on TNF-alpha and [IL-1beta] production from LPS stimulated human monocytes was investigated . Regulation IL1B PGA3 19737897 2186523 The extracellular release of [IL-1beta] in *response* to was ICE dependent , since the administration of an ICE inhibitor prior to PGA treatment blocked induction of IL-1beta . Regulation IL1B PGA4 19737897 2186524 The extracellular release of [IL-1beta] in *response* to was ICE dependent , since the administration of an ICE inhibitor prior to PGA treatment blocked induction of IL-1beta . Regulation IL1B PGA5 19737897 2186525 The extracellular release of [IL-1beta] in *response* to was ICE dependent , since the administration of an ICE inhibitor prior to PGA treatment blocked induction of IL-1beta . Regulation IL1B PGF 14611637 1162787 In rats , ( 2alpha ) and interleukin 1beta (IL-1beta) are *involved* in structural luteolysis , PGF ( 2alpha ) by increasing ovarian lipid peroxidation , and [IL-1beta] by reducing progesterone and increasing PGF ( 2alpha ) concentrations . Regulation IL1B PI3 17182583 1679845 This was not due to changes in IL-1beta mRNA steady-state levels or transcript stability , but to the *involvement* of in the repression of [IL-1beta] secretion . Regulation IL1B PI3 17182583 1679847 The present results demonstrate that are *involved* in the inhibition of [IL-1beta] secretion and in the induction of sIL-1Ra production in human blood monocytes by controlling different mechanisms in conditions mimicking chronic/sterile ( CE ( sHUT ) ) and acute/infectious ( LPS ) inflammation . Regulation IL1B PI3 18471882 1921598 We previously demonstrated that *regulate* differential production of [IL-1beta] and its specific inhibitor secreted IL-1 receptor antagonist ( sIL-1Ra ) by human monocytes . Regulation IL1B PIK3C3 17504920 1744643 *Participation* of kinase B and ERK1/2 pathways in [interleukin-1beta] stimulation of lactate production in Sertoli cells . Regulation IL1B PIK3CA 10593868 572835 We also show that the signaling pathways resulting in the induction of IL-1beta synthesis by rgp350 required protein kinase C and phosphatidylinositol 3,4,5 triphosphate kinase activities and occurred via activation of the NF-kappaB family of transcription factors.-D'Addario , M. , Ahmad , A. , Xu , J. W. , Menezes , J. Epstein-Barr virus envelope glycoprotein gp350 induces NF-kappaB activation and [IL-1beta] synthesis in human monocytes-macrophages *involving* PKC and . Regulation IL1B PIK3CA 18684863 1973553 Here we show that inhibition of HMG-CoA reductase by simvastatin treatment , mimicking MKD , results in increased [IL-1beta] secretion in a *dependent* manner . Regulation IL1B PIK3R1 10593868 572836 We also show that the signaling pathways resulting in the induction of IL-1beta synthesis by rgp350 required protein kinase C and phosphatidylinositol 3,4,5 triphosphate kinase activities and occurred via activation of the NF-kappaB family of transcription factors.-D'Addario , M. , Ahmad , A. , Xu , J. W. , Menezes , J. Epstein-Barr virus envelope glycoprotein gp350 induces NF-kappaB activation and [IL-1beta] synthesis in human monocytes-macrophages *involving* PKC and . Regulation IL1B PIK3R1 18684863 1973554 Here we show that inhibition of HMG-CoA reductase by simvastatin treatment , mimicking MKD , results in increased [IL-1beta] secretion in a *dependent* manner . Regulation IL1B PIK3R4 17504920 1744644 *Participation* of kinase B and ERK1/2 pathways in [interleukin-1beta] stimulation of lactate production in Sertoli cells . Regulation IL1B PLA2G1B 8832976 385871 The *role* of the cytosolic 85 kDa in [IL-1beta] induced human rheumatoid synovial fibroblast PGE2 formation was directly evaluated using an antisense phosphorothioate oligonucleotide to the initiation site of the 85 kDa PLA2 mRNA . Regulation IL1B PLA2G1B 9135823 427830 Stromelysin and plasmin activity , measured by degradation of casein and a synthetic substrate , were also unaffected by CT. Chondrocyte activity , assayed using a labeled specific substrate , was decreased by CT. Chondrocyte pre-incubation with CT significantly decreased the cell binding of labeled TNF alpha , but did not *affect* [IL-1 beta] cell binding . Regulation IL1B PPARG 20410836 2274327 We studied in rats the *effects* of the agonist , pioglitazone , on the regulation of [IL-1beta] , IL-1ra and IL-1 receptor I (IL-1RI) expression in ischaemic brain after occlusion of the middle cerebral artery for 90 min . Regulation IL1B PPP1R3B 20153259 2248519 Using PBMC from healthy individuals , we show that monocytes differentiated with IL-15 ( IL15-DC ) produced [IL-1beta] , IL-6 , IL-15 , IL-23 , TNFalpha and CCL20 in *response* to and activated contact dependent Th17 and Th1 responses from autologous CD4 ( + ) T cells . Regulation IL1B PPP5C 19628068 2112808 Neither nor DPN *affected* myocardial production of TNF-alpha or [IL-1beta] . Regulation IL1B PRKAA1 19853624 2196706 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( [IL-1 beta] , TNF-alpha ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Regulation IL1B PRKAA2 19853624 2196707 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( [IL-1 beta] , TNF-alpha ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Regulation IL1B PRKAB1 19853624 2196708 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( [IL-1 beta] , TNF-alpha ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Regulation IL1B PRKAB2 19853624 2196709 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( [IL-1 beta] , TNF-alpha ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Regulation IL1B PRKAG1 19853624 2196710 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( [IL-1 beta] , TNF-alpha ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Regulation IL1B PRKAG2 19853624 2196711 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( [IL-1 beta] , TNF-alpha ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Regulation IL1B PRL 16140971 1450993 To delineate the signaling mechanism from 16-kDa PRL , we examined the *effect* of 16-kDa on interleukin [IL-1beta-inducible] iNOS expression , which is regulated by two parallel pathways , one involving IFN regulatory factor 1 (IRF-1) and the other nuclear factor-kappaB (NF-kappaB) . Regulation IL1B PRL 9140083 428338 Here , we investigated the *effects* of GH and on the expression of interleukin (IL)-1alpha , [IL-1beta] and IL-6 in thymic stromal cells (TSC) . Regulation IL1B PTGS1 12193539 981335 Our data indicate that endogenous progenitor mRNA levels are low and are not *regulated* by [IL-1beta] . Regulation IL1B PTGS2 16584347 1544076 *Effects* of selective inhibitor and omega-3 fatty acid on serum [interleukin-1beta] , osteocalcin , and C-reactive protein levels in rats . Regulation IL1B PTGS2 16584347 1544079 The aim of this study was to evaluate the *effects* of selective inhibitor , celecoxib , and omega-3 fatty acid on serum levels of [interleukin 1-beta (IL-1beta)] , osteocalcin (OC) , and C-reactive protein (CRP) in experimental periodontitis . Regulation IL1B PTGS2 9863663 556125 *Role* of induction in [interleukin-1beta] induced attenuation of cultured human airway smooth muscle cell cyclic AMP generation in response to isoprenaline . Regulation IL1B PTGS2 9863663 556129 We investigated the *role* of induction and prostanoid release ( measured as PGE2 ) in [IL-1beta] induced attenuation of cyclic AMP generation in response to the beta-adrenoceptor agonist isoprenaline ( ISO ) . Regulation IL1B PTH 1785373 176013 Neither 17 beta-estradiol nor bovine ( 1-34 ) ( each at 10 nM ) , alone or in combination with LPS or TNF-alpha , *affected* [IL-1 beta] release . Regulation IL1B PTK2 11775830 766445 *Role* of in [IL-1 beta] induced activation of mitogen activated protein kinase in fibroblast-like synoviocytes of rheumatoid arthritis . Regulation IL1B PTK2 7519214 265509 *Involvement* of protein kinase C and in lipopolysaccharide induced TNF-alpha and [IL-1 beta] production by human monocytes . Regulation IL1B PTK2 8188366 256777 Finally , our results , obtained with protein tyrosine kinase inhibitors and antiphosphotyrosine Western blotting ( immunoblotting ) , indicate that is *involved* in MAM induced [IL-1 beta] and TNF-alpha gene expression in the THP-1 monocytic cell line . Regulation IL1B PTK6 11775830 766446 *Role* of in [IL-1 beta] induced activation of mitogen activated protein kinase in fibroblast-like synoviocytes of rheumatoid arthritis . Regulation IL1B PTK6 7519214 265510 *Involvement* of protein kinase C and in lipopolysaccharide induced TNF-alpha and [IL-1 beta] production by human monocytes . Regulation IL1B PTK6 8188366 256778 Finally , our results , obtained with protein tyrosine kinase inhibitors and antiphosphotyrosine Western blotting ( immunoblotting ) , indicate that is *involved* in MAM induced [IL-1 beta] and TNF-alpha gene expression in the THP-1 monocytic cell line . Regulation IL1B PTK7 11775830 766447 *Role* of in [IL-1 beta] induced activation of mitogen activated protein kinase in fibroblast-like synoviocytes of rheumatoid arthritis . Regulation IL1B PTK7 7519214 265511 *Involvement* of protein kinase C and in lipopolysaccharide induced TNF-alpha and [IL-1 beta] production by human monocytes . Regulation IL1B PTK7 8188366 256779 Finally , our results , obtained with protein tyrosine kinase inhibitors and antiphosphotyrosine Western blotting ( immunoblotting ) , indicate that is *involved* in MAM induced [IL-1 beta] and TNF-alpha gene expression in the THP-1 monocytic cell line . Regulation IL1B PTX3 9227316 443181 The present study concerns the *effect* of the xanthine derivates lisofylline ( LSF ) and on the production of pro-inflammatory cytokines tumour-necrosis factor-alpha (TNF-alpha) and [interleukin-1 beta (IL-1 beta)] and the de-activating cytokine interleukin-10 (IL-10) by human leucocytes during stimulation with lipopolysaccharide (LPS) , heat killed Gram negative bacteria (GNB) or Gram positive bacteria ( GPB ) . Regulation IL1B PTX4 9227316 443180 The present study concerns the *effect* of the xanthine derivates lisofylline ( LSF ) and on the production of pro-inflammatory cytokines tumour-necrosis factor-alpha (TNF-alpha) and [interleukin-1 beta (IL-1 beta)] and the de-activating cytokine interleukin-10 (IL-10) by human leucocytes during stimulation with lipopolysaccharide (LPS) , heat killed Gram negative bacteria (GNB) or Gram positive bacteria ( GPB ) . Regulation IL1B RAC1 11557585 861396 In this study , overexpression of constitutively active or its dominant negative mutant did not *affect* [IL-1beta] induction of iNOS . Regulation IL1B RAC1 18684863 1973555 Here we show that inhibition of HMG-CoA reductase by simvastatin treatment , mimicking MKD , results in increased [IL-1beta] secretion in a *dependent* manner . Regulation IL1B RBBP4 16684958 1598530 In the present study , we investigated the *effects* of 2 inhibitors on [IL-1beta] secretion : suberoylanilide hydroxamic acid and a newly developed hydroxamic acid derived compound ITF2357 . Regulation IL1B RBBP4 16684958 1598534 These inhibitors do not *affect* the synthesis or intracellular localization of [IL-1beta] but both strongly reduce the levels of extracellular IL-1beta by preventing the exocytosis of IL-1beta containing secretory lysosomes . Regulation IL1B RBBP7 16684958 1598531 In the present study , we investigated the *effects* of 2 inhibitors on [IL-1beta] secretion : suberoylanilide hydroxamic acid and a newly developed hydroxamic acid derived compound ITF2357 . Regulation IL1B RBBP7 16684958 1598535 These inhibitors do not *affect* the synthesis or intracellular localization of [IL-1beta] but both strongly reduce the levels of extracellular IL-1beta by preventing the exocytosis of IL-1beta containing secretory lysosomes . Regulation IL1B RELA 10080875 597473 *Involvement* of p50/p65 heterodimer in activation of the human [pro-interleukin-1beta] gene at two subregions of the upstream enhancer element . Regulation IL1B RELA 10760471 683533 The results show that the [IL-1beta] induced expression of group V sPLA ( 2 ) mRNA was time *dependent* and , similar to that of group IIA sPLA ( 2 ) mRNA , involves activation of . Regulation IL1B RELA 11274229 797590 These data suggested that ( 1 ) constitutive and [IL-1beta-inducible] expression of MCP-1 was differently *regulated* by AP-1 and and ( 2 ) t-RA inhibited selectively the constitutive expression of MCP-1 via intervention in the AP-1 pathway . Regulation IL1B RELA 11930628 894645 Enhancement of activity of and AP-1 may positively *regulate* the production of IL-8 and [IL-1 beta] in the airflow obstruction . Regulation IL1B RELA 12021045 942768 In this study , we investigated the possible *role* of the in [IL-1beta] signaling , leading to the expression of COX-2 in human amnion cell culture . Regulation IL1B RELA 12676746 1076880 We tested the hypothesis that IL-6 production in muscle cells is regulated by [IL-1beta] and that mitogen activated protein (MAP) kinase signaling and activation are *involved* in IL-1beta induced IL-6 production . Regulation IL1B RELA 12920043 1174005 Inhibiting did not *affect* either [IL-1beta] secretion or phenotypic maturation but rather sensitized DCs to Fas mediated apoptosis . Regulation IL1B RELA 12946102 1136782 *Involvement* of the transcription factor in expression of IL-1beta1 and [IL-1beta2] was demonstrated . Regulation IL1B RELA 15063239 1230849 *plays* a central role in the regulation of [IL-1beta] and subsequent IL-1beta dependent inflammatory processes . Regulation IL1B RELA 16580131 1562453 Taken together , these results suggest that the induction of [IL-1beta] and TNFalpha in endotoxin stimulated microglia is differentially *regulated* at the level of activation . Regulation IL1B RELA 19248089 2045031 Matrix metalloproteinase 13 was induced by [IL-1beta] in a *dependent* manner . Regulation IL1B RELA 19454703 2084581 In direct correlation with the increased viral internalization , antiviral Abs amplified the innate immune response to adenovirus as determined by the expression of *dependent* genes , type I IFNs , and caspase dependent [IL-1beta] maturation . Regulation IL1B RELA 8021507 263081 *regulates* [IL-1 beta] transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site . Regulation IL1B RELA 8144314 242477 Therefore , we investigated whether cyclic AMP , protein kinase A and are *involved* in the induction of [IL-1 beta] release by human peripheral blood monocyte derived macrophages ( HPBM ) stimulated with a specific IL-1 beta inducer , 9-hydroxyoctadecadienoic acid ( 9-HODE ) . Regulation IL1B RELA 9079634 420551 *Role* of in tumor necrosis factor-alpha and [interleukin-1beta] regulation . Regulation IL1B RELA 9510209 491890 The *role* of activation in BK-induced [IL-1beta] synthesis was demonstrated by the ability of BK to stimulate increased chloramphenicol acetyltransferase (CAT) activity in A549 cells transfected with a reporter plasmid containing three kappaB enhancers from the IL-1beta gene , while deletion of the kappaB enhancer sequences eliminated BK-stimulated CAT activity . Regulation IL1B RHO 18038269 1894660 By using pharmacological inhibitors , it was suggested that G ( i ) activation and subsequent reactive oxygen species ( ROS ) production were *involved* in [IL-1 beta] induction . Regulation IL1B RNF19A 9624172 511385 Differential *roles* of extracellular signal regulated kinase-1/2 and ( MAPK ) in [interleukin-1beta-] and tumor necrosis factor-alpha induced low density lipoprotein receptor expression in HepG2 cells . Regulation IL1B S100A12 14636837 1171330 In this study , the *effects* of neuropeptides substance P ( SP ) and on production of pro-inflammatory cytokines TNF and [IL-1 beta] by macrophages were considered . Regulation IL1B S100A12 17301363 1184922 In this study the *effect* of neuropeptides substance P ( SP ) and on [IL-1 beta] production by herpes simplex type-1 ( HSV-1 ) -infected and also uninfected mouse peritoneal macrophages were considered . Regulation IL1B S100A12 19299480 2106081 In the present study , we demonstrate that is *involved* in morphine tolerance by differentially regulating the ERK dependent up-regulation of [IL-1beta] , TNF-alpha , and microsomal prostaglandin E synthase-1 ( mPGES-1 ) in astrocytes and p38 dependent up-regulation of IL-6 in microglia in the rat spinal cord . Regulation IL1B SAA1 10679217 668842 This study focuses on the *effect* of AI , , and HDL from healthy ( N-HDL ) and acute phase individuals ( AP-HDL ) on the release of TNF-alpha , [IL-1beta] , and IL-8 by human blood neutrophils . Regulation IL1B SERPINA1 1630052 191931 In the present study , we investigated the *effect* of on the production of interleukin-1 alpha ( IL-1 alpha , ELISA ) , [IL-1 beta] ( ELISA ) , and tumor necrosis factor alpha ( TNF alpha , ELISA ) by alveolar macrophages ( AM ) recruited by bronchoalveolar lavage (BAL) from patients with lung cancer and benign pulmonary diseases . Regulation IL1B SERPINC1 11798464 892480 *Effects* of on tumor necrosis factor-alpha and [interleukin-1beta] synthesis in vascular smooth muscle cells . Regulation IL1B SERPINF1 20352441 2281953 The *role* of on the expressions of GS and [interleukin-1beta (IL-1beta)] in retinal Müller cells under normal and high glucose conditions was measured by western blotting , real-time RT-PCR , or immunocytochemistry . Regulation IL1B SETBP1 8960643 402282 In *response* to , patients with sepsis and patient with septic shock demonstrated significantly decreased release of TNF-alpha and [IL-1beta] . Regulation IL1B SIRPA 12483539 1024779 A *role* for in [IL-1beta-] and TNFalpha dependent signaling . Regulation IL1B SIRPA 12483539 1024782 We investigated the *role* of in [IL-1beta-] and TNFalpha dependent signaling that leads to the activation of Erk 1/2 and Akt . Regulation IL1B SLC33A1 14617687 1209982 These results suggest that in rats , brain ANG II and receptors are *involved* in the LPS induced production of brain [IL-1beta] , thus contributing to the fever induced by the presence of LPS within the brain . Regulation IL1B SMN1 17451462 1778053 We report here the *effects* of the most potent SMase inhibitor , , on the LPS mediated release of tumour necrosis factor-alpha , [interleukin-1beta] and interleukin-6 from THP-1 macrophages and the pathology of dextran sulphate sodium (DSS) induced colitis in mice . Regulation IL1B SMPD2 10704249 672809 These data suggest that , a key enzyme of the sphingomyelin signal transduction pathway , might be *involved* in [IL-1beta] signalling in the brain and that activation of the enzyme requires the IL-1 receptor type 1 . Regulation IL1B SOD1 10195945 604252 Although AT decreased superoxide release from activated monocytes , and catalase had no *effect* on [IL-1 beta] release . Regulation IL1B SOD2 10195945 604253 Although AT decreased superoxide release from activated monocytes , and catalase had no *effect* on [IL-1 beta] release . Regulation IL1B SOD3 10195945 604254 Although AT decreased superoxide release from activated monocytes , and catalase had no *effect* on [IL-1 beta] release . Regulation IL1B SP1 18772363 1985853 The *role* of in [IL-1beta] and H. pylori mediated regulation of H , K-ATPase gene transcription . Regulation IL1B SSR1 8006515 258095 In the present study , the *effect* of the lipophilic nitrone spin ( PBN ) on lipoprotein oxidation and subsequent release of [interleukin-1 beta] was examined . Regulation IL1B SST 10727753 678090 Although had no *effect* on lung TNF-alpha or [IL-1beta] level , it increased IL-6 . Regulation IL1B SST 8982099 403798 In the present study , we have investigated the *effect* in vitro of gastrin releasing peptide ( GRP , 10 ( -10 ) M ) , neuropeptide Y ( NPY , 10 ( -10 ) M ) , ( 10 ( -10 ) M ) and vasoactive intestinal peptide ( VIP , 10 ( -9 ) M ) on the production of [IL-1 beta] , IL-6 and TNF alpha by peripheral whole blood cells from healthy young and old people . Regulation IL1B STAT3 19299019 2064081 These results highlight the complex *role* of in cytokine production and the key role of STAT3 tyrosine phosphorylation in [IL-1beta] and IL-6 production in response to inflammation . Regulation IL1B STK10 9641167 514143 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Regulation IL1B STK11 9641167 514144 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Regulation IL1B STK16 9641167 514145 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Regulation IL1B STK19 9641167 514146 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Regulation IL1B STK24 9641167 514147 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Regulation IL1B STK25 9641167 514148 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Regulation IL1B STK3 9641167 514149 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Regulation IL1B STK31 9641167 514150 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Regulation IL1B STK33 9641167 514152 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Regulation IL1B STK35 9641167 514153 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Regulation IL1B STK36 9641167 514154 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Regulation IL1B STK38 9641167 514156 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Regulation IL1B STK39 9641167 514155 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Regulation IL1B STK4 9641167 514151 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Regulation IL1B STK40 9641167 514157 Additionally , TGF beta involved serine/threonine kinase and G-protein pathways , and [IL-1beta] *involved* calmodulin , and PKC pathways in upregulating LDLr . Regulation IL1B STS 16547271 1537799 Distinct *roles* of TLR2 and the adaptor in [IL-1beta/IL-18] secretion in response to Listeria monocytogenes . Regulation IL1B STS 16547271 1537803 These results demonstrate that TLR2 and *regulate* the secretion of [IL-1beta] via distinct mechanisms in response to Listeria . Regulation IL1B STS 17429439 1766336 We show here that key components of the inflammasome are present in human keratinocytes and that CS like trinitro-chlorobenzene induce *dependent* [IL-1beta] and IL-18 processing and secretion . Regulation IL1B STS 19319132 2073573 Production of mature [IL-1beta] is *dependent* on a caspase-1 activating protein complex called the NALP3 inflammasome , composed of NALP3 , , and CARD8 . Regulation IL1B SULT1E1 9643476 514461 A macrophage cell line ( J774-A1 ) was used to measure the *effects* of on tumor necrosis factor-alpha (TNF-alpha) and [interleukin-1beta (IL-1beta)] secretion . Regulation IL1B SYK 19339971 2080761 Here we demonstrate that the tyrosine kinase , operating downstream of several immunoreceptor tyrosine based activation motif ( ITAM ) -coupled fungal pattern recognition receptors , *controls* both [pro-IL-1beta] synthesis and inflammasome activation after cell stimulation with Candida albicans . Regulation IL1B SYK 20401456 2282157 Recent work has uncovered essential *roles* for the and the cytosolic NLRP3 inflammasome for [Interleukin-1beta (IL-1beta)] production in innate antifungal immunity . Regulation IL1B SYNCRIP 19454352 2084492 The known fungal pattern recognition receptors TLR2 and Dectin-1 regulate IL-1beta gene transcription , whereas the NLRP3 containing proinflammatory , the NLRP3 inflammasome , *controls* caspase-1 mediated cleavage of [pro-IL-1beta] . Regulation IL1B TANK 10201981 605778 In addition , our data suggest that is *involved* in [IL-1 beta] signaling in HT-29 cells . Regulation IL1B TAT 20336759 2230979 specific C/EBP and NF-kappaB transcription factor binding elements within the IL-1beta promoter are involved in *regulation* of [IL-1beta] production . Regulation IL1B TGFA 1940795 170622 Regulation of cytokine production in the human thymus : epidermal growth factor and *regulate* mRNA levels of interleukin 1 alpha (IL-1 alpha) , [IL-1 beta] , and IL-6 in human thymic epithelial cells at a post-transcriptional level . Regulation IL1B TGFB1 16226884 1483585 However HAS2 transcription increased 10-fold in *response* to and [IL-1beta] . Regulation IL1B TGFB1 17426628 1723996 Expression of TIMP-3 mRNA in NP was upregulated by but was not *affected* by [IL-1beta] . Regulation IL1B TGFB1 2240083 144735 On the basis of these findings , we suggest that the increase in decidual [interleukin-1 beta] and human leukocyte antigen HLA-DR alpha during pregnancy may be involved in maternal recognition of the fetal semiallograft and that production may *regulate* the local maternal immune response and prevent rejection of the fetus . Regulation IL1B TGFB1 7751003 306735 We investigated the *effect* of ( TGF-beta ) on [interleukin-1 beta (IL-1 beta)] induction of IL-6 and IL-8 mRNA levels and protein production by human RPE cells . Regulation IL1B TGFB1 8408003 233210 IL-11 mRNA was induced in chondrocytes in *response* to and [IL-1 beta] . Regulation IL1B TGFB1 8889469 391655 did not *affect* [IL-1 beta] mRNA levels but caused variable increases in IL-1 beta protein levels . Regulation IL1B TGFB2 2240083 144736 On the basis of these findings , we suggest that the increase in decidual [interleukin-1 beta] and human leukocyte antigen HLA-DR alpha during pregnancy may be involved in maternal recognition of the fetal semiallograft and that production may *regulate* the local maternal immune response and prevent rejection of the fetus . Regulation IL1B TGFB2 7751003 306736 We investigated the *effect* of ( TGF-beta ) on [interleukin-1 beta (IL-1 beta)] induction of IL-6 and IL-8 mRNA levels and protein production by human RPE cells . Regulation IL1B TGFB2 9704780 525622 The purpose of this study was to determine the inhibitory *effects* of anti-interleukin-1beta and on the production of [interleukin-1beta] and prostaglandin E2 by human decidual cells . Regulation IL1B TGFB3 2240083 144737 On the basis of these findings , we suggest that the increase in decidual [interleukin-1 beta] and human leukocyte antigen HLA-DR alpha during pregnancy may be involved in maternal recognition of the fetal semiallograft and that production may *regulate* the local maternal immune response and prevent rejection of the fetus . Regulation IL1B TGFB3 7751003 306737 We investigated the *effect* of ( TGF-beta ) on [interleukin-1 beta (IL-1 beta)] induction of IL-6 and IL-8 mRNA levels and protein production by human RPE cells . Regulation IL1B TLR1 18184197 1856594 To a lesser extent , tumour necrosis factor-alpha and [IL-1beta] *responses* to stimulation were also compromised . Regulation IL1B TLR1 19544485 2103837 In contrast , TLR4 , TLR9 and receptors are not *involved* in [IL-1beta] induction . Regulation IL1B TLR10 18184197 1856602 To a lesser extent , tumour necrosis factor-alpha and [IL-1beta] *responses* to stimulation were also compromised . Regulation IL1B TLR2 16547271 1537800 Distinct *roles* of and the adaptor ASC in [IL-1beta/IL-18] secretion in response to Listeria monocytogenes . Regulation IL1B TLR2 18184197 1856595 To a lesser extent , tumour necrosis factor-alpha and [IL-1beta] *responses* to stimulation were also compromised . Regulation IL1B TLR2 18773284 2028352 Additionally , there was a synergistic *effect* of with NOD2 stimulation on induction of [IL-1 beta] in patients , whereas IL-10 was synergistically induced in healthy subjects . Regulation IL1B TLR2 19666104 2182971 In particular , there was a marked increase in pro-inflammatory IL-1beta , IL-6 , and TNFalpha responses following , and [IL-1beta] *response* following TLR 4 stimulation in monocyte cultures from children with ASD ( p < 0.04 ) . Regulation IL1B TLR3 18184197 1856596 To a lesser extent , tumour necrosis factor-alpha and [IL-1beta] *responses* to stimulation were also compromised . Regulation IL1B TLR3 18725521 1955979 These results implicate a novel role for caspase-8 in the production of biologically active [IL-1beta] in *response* to and TLR4 stimulation . Regulation IL1B TLR4 11992285 938693 Production of tumor necrosis factor (TNF) and interleukin (IL)-1alpha and [IL-1beta] by mouse macrophages in response to C. albicans stimulation was not *affected* by , and the candidacidal capacities of the neutrophils and macrophages of C3H/HeJ mice were normal . Regulation IL1B TLR4 18184197 1856597 To a lesser extent , tumour necrosis factor-alpha and [IL-1beta] *responses* to stimulation were also compromised . Regulation IL1B TLR4 18195026 1883717 When macrophages were stimulated with rPLY , the production of IL-1alpha , [IL-1beta] , and IL-18 was strongly induced in a *dependent* manner , whereas lipopolysaccharide , a canonical TLR4 agonist , hardly induced these cytokines . Regulation IL1B TLR4 18725521 1955980 These results implicate a novel role for caspase-8 in the production of biologically active [IL-1beta] in *response* to TLR3 and stimulation . Regulation IL1B TLR4 19028791 2022901 FXR activation by natural and synthetic ligands in these cell types attenuated [IL-1beta] , IL-6 , and TNF-alpha gene induction in *response* to activation by LPS . Regulation IL1B TLR5 18184197 1856598 To a lesser extent , tumour necrosis factor-alpha and [IL-1beta] *responses* to stimulation were also compromised . Regulation IL1B TLR6 18184197 1856603 To a lesser extent , tumour necrosis factor-alpha and [IL-1beta] *responses* to stimulation were also compromised . Regulation IL1B TLR7 18184197 1856599 To a lesser extent , tumour necrosis factor-alpha and [IL-1beta] *responses* to stimulation were also compromised . Regulation IL1B TLR8 18184197 1856600 To a lesser extent , tumour necrosis factor-alpha and [IL-1beta] *responses* to stimulation were also compromised . Regulation IL1B TLR9 18184197 1856601 To a lesser extent , tumour necrosis factor-alpha and [IL-1beta] *responses* to stimulation were also compromised . Regulation IL1B TLR9 19544485 2103838 In contrast , TLR4 , and TLR1 receptors are not *involved* in [IL-1beta] induction . Regulation IL1B TMED7 20545441 2279493 It was found that the ALV expression markedly reduced the production of TNF-alpha , but did not *affect* the production of [IL-1beta] , IL-6 , and 12 , and cell proliferative activity . Regulation IL1B TNF 10718111 579355 A rapid increase in PGHS-2 ( but not PGHS-1 ) mRNA expression was observed in *response* to and [IL-1beta] . Regulation IL1B TNF 10843739 700318 In contrast with MO , purified LY and non fractionated PBMC expressed IL-8 in *response* to exogenous , similar to exogenous IL-1alpha and [IL-1beta] . Regulation IL1B TNF 11972797 934265 The aim of this study was to determine whether , in the absence of [IL-1beta] and IL-6 , may *play* an equivalent pro-inflammatory role , or if an anti-inflammatory cytokine profile dominates . Regulation IL1B TNF 12595589 1061696 Fetal human enterocytes have an exaggerated IL-8 secretion in *response* to and [IL-1beta] . Regulation IL1B TNF 14734475 1199281 However , in the resistant cells , the production of [IL-1beta] and IL-6 were specifically impaired in *response* to . Regulation IL1B TNF 15036245 1223862 We compared the production of IL-1alpha , [IL-1beta] , and of IL-1Ra isoforms by cultured human dermal ( HDF ) and synovial fibroblasts ( HSF ) in *response* to IL-1alpha , , or direct T cell membrane contact . Regulation IL1B TNF 15358691 1293569 In order to better understand the control of IL-1beta activity in the airway mucosa , the *role* ( s ) of , cyclic adenosine monophosphate ( cAMP ) and cyclic guanosine monophosphate ( cGMP ) in the release of [IL-1beta] and its inhibitors by cultured HAECs were examined . Regulation IL1B TNF 16859503 1663415 Adhered monocytes , after 3-day preincubation with IL-10 and M-CSF , could produce more [IL-1beta] and IL-6 in *response* to in the presence of dibutyryl cAMP , as compared with the cells preincubated with or without IL-10 or M-CSF alone . Regulation IL1B TNF 1698309 141440 [IL-1 beta] and *responses* of Mo from males ( 18-35 years ) with newly diagnosed ( n = 10 ) and long standing IDDM ( n = 10 ) and from age- and HLA-DR matched healthy males ( n = 10 ) were studied . Regulation IL1B TNF 17295604 1725901 The data are consistent with a *role* for , and possibly for [IL-1 beta] , in mediating increased bone resorption during estrogen deficiency in women . Regulation IL1B TNF 17369098 1748310 Maternal genomic variations influence both and [interleukin-1beta] *response* to BV-related organisms ( anaerobic Gram negative bacteria and Gardnerella vaginalis in particular ) in the vagina and the risk of spontaneous preterm birth . Regulation IL1B TNF 17438450 1729273 alpha and [IL-1beta] *responses* to LPS partially recovered , whereas IL-8 and IL-10 responses recovered . Regulation IL1B TNF 1918980 168448 Thus , we report that Il-1 and *regulate* [IL-1 beta] gene expression via both transcriptional and post-transcriptional mechanisms in vitro . Regulation IL1B TNF 2069802 162592 Using a whole blood in vitro model , we have investigated the *effect* of Escherichia coli ( E. coli ) , Streptococcus agalactiae ( group B streptococci , GBS ) and on the generation of lactoferrin (LF) , [interleukin-1 beta (IL-1)] and tissue thromboplastin (TPL) in healthy newborns at term and their mothers . Regulation IL1B TNF 2112081 133023 To understand the processes regulating inflammation and fibrosis in the human lung , we characterized the *effects* of recombinant interleukin-1 , , and gamma interferon on fibroblast proliferation , collagen production , interleukin-1-alpha production , [interleukin-1-beta] production , and interleukin-6 production . Regulation IL1B TNF 2221137 142844 These data support the hypotheses that [IL-1 beta] is responsible for a significant part of LPS fever and that *acts* as an endogenous antipyretic to limit the magnitude of LPS fever in the rat . Regulation IL1B TNF 2556620 122138 In both CMV infected and uninfected cultures , significant amounts of IL-1 beta protein were not detected until 24 h post induction , while maximum amounts of TNF were detected in culture supernatants by 3 h post induction , suggesting that may *play* a role in [IL-1 beta] induction . Regulation IL1B TNF 7622213 315755 in fact , complete inhibition of does not *affect* [IL-1 beta] production and vice versa . Regulation IL1B TNF 8653494 366578 The stimulatory *effect* of on [IL-1 beta] production was accompanied by enhanced PGE2 formation . Regulation IL1B TNF 8653494 366579 When PHT and TNF alpha were added simultaneously , the drug potentiated the stimulatory *effect* of on both [IL-1 beta] production and PGE2 formation . Regulation IL1B TNF 8840155 386693 The data provide evidence for an in vivo *role* for epidermal IL-1 alpha , IL-1 beta and transcription in the regulation of [IL-1 beta] and TNF-alpha polypeptide levels in the epidermis in response to this common contact allergen . Regulation IL1B TNF 8918573 396317 They have been shown previously to produce the cytokine [IL-1 beta] in *response* to stimulation with . Regulation IL1B TNF 9079634 420549 Role of NF-kappaB in and [interleukin-1beta] *regulation* . Regulation IL1B TNF 9584910 504449 When gingival fibroblasts were treated simultaneously with triclosan ( 0.25 , 0.5 microg/ml ) and TNFalpha ( 10 ng/ml ) , the stimulatory *effect* of on [IL-1beta] production was reduced by the agent . Regulation IL1B TNF 9605181 507580 These results provide evidence that IL-8 and were *responsible* for the production of [IL-1beta] and IL-1Ra , and that IL-1beta was responsible for the second phase of IL-1beta and IL-8 production . Regulation IL1B TNF 9712064 527154 Reverse-transcription PCR analysis indicated up-regulation of mRNA for IL-8 as well as for [IL-1 beta] in *response* to tryptase or . Regulation IL1B TNF 9722689 529141 PGE2 , [IL-1 beta] , and *responses* in diabetics as modifiers of periodontal disease expression . Regulation IL1B TNFAIP1 1339917 209242 The *effect* of methyl on [IL-1 beta] production on Day I of the culture was small . Regulation IL1B TNFRSF1B 11950256 930298 TNFalpha-antagonists infliximab and inhibited TNFalpha induced NO production in a dose dependent manner but they had no *effect* on [IL-1beta-] , IL-17- and LPS stimulated NO synthesis . Regulation IL1B TRAF6 19342688 2056854 The *role* and relative contribution of MyD88 , IRAK1 , and adaptor proteins in [IL-1beta] regulation of aggrecanase-1 ( ADAMTS-4 ) is unknown . Regulation IL1B TSC22D3 17208592 1681336 The *effect* of on LPS- , [IL-1beta-] , and polyinosinic : polycytidylic acid induced NF-kappaB activation was assessed in BEAS-2B cells overexpressing GILZ . Regulation IL1B VCAM1 15707597 1372900 Trophoblast interactions with endothelial cells are increased by [interleukin-1beta] and tumour necrosis factor alpha and *involve* and alpha4beta1 . Regulation IL1B VEGFA 10408390 629823 These findings suggest that [IL-1beta] *regulates* VEGF expression in human colon cancer cells by increasing transcription of the gene . Regulation IL1B VIP 12873794 1114341 In the present study , we have investigated the in vitro *effect* of calcitonin related peptide ( CGRP ) , neuropeptide Y (NPY) , substance P ( SP ) and at concentrations of 10 ( -8 ) , 10 ( -9 ) and 10 ( -10 ) M on the production of different proinflammatory cytokines or chemokines such as [IL-1beta] , IL-6 and TNFalpha by peripheral whole blood cells from patients with rheumatoid arthritis , as well as from osteoarthritis patients studied as a control group without immunoinflammatory background . Regulation IL1B VIP 8982099 403799 In the present study , we have investigated the *effect* in vitro of gastrin releasing peptide ( GRP , 10 ( -10 ) M ) , neuropeptide Y ( NPY , 10 ( -10 ) M ) , somatostatin ( 10 ( -10 ) M ) and ( VIP , 10 ( -9 ) M ) on the production of [IL-1 beta] , IL-6 and TNF alpha by peripheral whole blood cells from healthy young and old people . Regulation IL1B WDR61 1710753 158271 The magnitude of the *effects* of on [IL-1 beta] mRNA levels matched closely the effects seen at the level of protein synthesis , suggesting that the effects of PAF on IL-1 beta release may result largely from its effects on IL-1 beta mRNA levels . Regulation IL1B WDR61 2293896 127476 To assess the *effect* of on [IL-1 beta] synthesis , THP-1 cell pellet proteins were separated by SDS-PAGE , blotted , and immunostained to detect IL-1 beta . Regulation IL1B WNK1 10080875 597469 *Involvement* of NF-kappaB heterodimer in activation of the human [pro-interleukin-1beta] gene at two subregions of the upstream enhancer element . Regulation IL1B WNT11 16754689 1590194 Opposing *roles* of WNT-5A and in [interleukin-1beta] regulation of type II collagen expression in articular chondrocytes . Regulation IL1B WNT5A 16754689 1590195 Opposing *roles* of and WNT-11 in [interleukin-1beta] regulation of type II collagen expression in articular chondrocytes . Regulation IL1B ZGLP1 16720054 1570302 In this study , we investigated the expression of glucagon-like peptide-1 (GLP-1) and its receptor , and the *effects* of on lipopolysaccharide (LPS) induced [IL-1beta] mRNA expression and IL-1beta production in glia . Regulation IL1B ZP2 9053458 417242 In the present report we investigated the *role* of microglial receptor in [IL-1 beta] release triggered by LPS . Regulation IL1R1 IL1B 15665043 1402421 IL-1beta also synergizes with OSM to increase VEGF release , likely as a result of *effects* of on VEGF mRNA stability as well as effects of OSM on [IL-1R1] expression . Regulation IL1R1 IL1B 17321804 1740864 Taking together , the present study elucidates that PC12 cells bear [interleukin-1 receptor] and *response* to stimulation . Regulation IL1R1 IL1B 22572995 2638068 Collectively , the results indicated that *regulates* expression of [IL1R1] and IL1RAP and stimulates expression of PTGS1 and PTGS2 that are considered to be the most rate limiting enzymes for endometrial synthesis of PGs during the peri-implantation period of pregnancy in pigs . Regulation IL1R1 IL1B 8997672 404612 We investigated the expression of interleukin-1 receptors (IL-1R) on the surfaces of cultured gingival fibroblasts derived from healthy and inflamed gingiva and the *effects* of IL-1 alpha and and prostaglandin E2 ( PGE2 ) on [IL-1R] expression . Regulation IL1R1 IL1B 9047079 406011 Soluble type II [interleukin 1 receptor] ( IL-1r II ) and interleukin 1 receptor antagonist ( IL-1ra ) *regulate* inflammation by competitively inhibiting the binding of to the signalling IL-1 receptor . Regulation IL1R1 IL1B 9314581 455678 *regulates* Vero cell [interleukin-1 receptor type I] messenger ribonucleic acid expression . Regulation IL1R1 IL1B 9314581 455681 To determine the *effect* of on [IL-1R] tI mRNA expression in Vero cells , quantitative competitive PCR methodology was developed . Regulation IL1R1 IL1B 9314581 455682 Treatment with anti-IL-1 beta antibody ablate the inhibitory *effect* of ( 100 IU/ml ) on [IL-1R] tI mRNA expression . Regulation IL1R1 TNF 19435506 2106939 Quantitative real-time polymerase chain reaction was used to assess the *effect* of or IL-beta stimulation on the expression of matrix metalloproteinase (MMP)-3 , -9 and -13 , TNF-alpha , TNF receptor 1 (TNF-R1) , TNF receptor 2 (TNF-R2) , IL-1alpha , IL-1beta , [IL-1 receptor 1 (IL-1R1)] and IL-1 receptor antagonist (IL-1Ra) . Regulation IL1R2 CRH 12864977 1111786 In an attempt to define the possible *role* of on lipopolysaccharide (LPS) induced type I [interleukin-1 receptor] ( IL-1R1 ) , IL-1alpha , and IL-1beta mRNAs in the pituitary , adrenal gland and spleen , we used CRH-deficient ( knockout , KO ) mouse in this study . Regulation IL1R2 IFNB1 19741489 2168238 Mechanical ventilation induces a [Toll/interleukin-1 receptor] domain containing adapter inducing *dependent* inflammatory response in healthy mice . Regulation IL1R2 IL10 12569683 1029538 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL10 2969889 95622 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL11 12569683 1029539 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL11 2969889 95623 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL13 12569683 1029540 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL13 2969889 95624 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL15 12569683 1029541 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL15 2969889 95625 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL16 12569683 1029542 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL16 2969889 95626 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL18 12569683 1029543 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL18 2969889 95627 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL19 12569683 1029544 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL19 2969889 95628 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL1B 17321804 1740865 Taking together , the present study elucidates that PC12 cells bear [interleukin-1 receptor] and *response* to stimulation . Regulation IL1R2 IL1B 9047079 406013 Soluble type II [interleukin 1 receptor] ( IL-1r II ) and interleukin 1 receptor antagonist ( IL-1ra ) *regulate* inflammation by competitively inhibiting the binding of to the signalling IL-1 receptor . Regulation IL1R2 IL2 12569683 1029545 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL2 2969889 95629 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL20 12569683 1029546 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL20 2969889 95630 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL21 12569683 1029547 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL21 2969889 95631 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL22 12569683 1029530 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL22 2969889 95614 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL24 12569683 1029528 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL24 2969889 95612 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL25 12569683 1029529 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL25 2969889 95613 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL26 12569683 1029534 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL26 2969889 95618 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL27 12569683 1029535 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL27 2969889 95619 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL3 12569683 1029548 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL3 2969889 95632 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL31 12569683 1029536 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL31 2969889 95620 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL32 12569683 1029533 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL32 2969889 95617 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL33 12569683 1029532 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL33 2969889 95616 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL34 12569683 1029537 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL34 2969889 95621 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL37 12569683 1029531 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL37 2969889 95615 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL4 12569683 1029549 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL4 2969889 95633 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL5 12569683 1029550 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL5 2969889 95634 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL6 12569683 1029551 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL6 2969889 95635 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL7 12569683 1029552 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL7 2969889 95636 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL8 12569683 1029553 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL8 2969889 95637 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IL9 12569683 1029554 [ *Effect* of on expression of [interleukin-1 receptor] in KM mice sciatic nerves before and after injuries ] . Regulation IL1R2 IL9 2969889 95638 Modulation of [interleukin-1 receptor] expression and *response* in fibroblasts by platelet derived growth factor . Regulation IL1R2 IRAK4 9047079 406012 Soluble type II [interleukin 1 receptor] ( IL-1r II ) and interleukin 1 receptor antagonist ( IL-1ra ) *regulate* inflammation by competitively inhibiting the binding of IL-1 beta to the signalling . Regulation IL1R2 MYD88 16412507 1581707 The [interleukin-1 receptor/toll-like] receptor ( IL-1R/TLR ) superfamily signaling *involves* myeloid differentiation factor 88 ( ) that acts as an important adapter protein . Regulation IL1R2 SMAD6 16951688 1615671 negatively *regulates* [interleukin 1-receptor-Toll-like] receptor signaling through direct interaction with the adaptor Pellino-1 . Regulation IL1R2 ST2 15004556 1228056 We show here that the membrane bound form of negatively *regulated* type I [interleukin 1 receptor] ( IL-1RI ) and Toll-like receptor 4 (TLR4) but not TLR3 signaling by sequestrating the adaptors MyD88 and Mal . Regulation IL1R2 TRAF6 16378096 1512548 Association of beta-arrestin and negatively *regulates* Toll-like [receptor-interleukin 1 receptor] signaling . Regulation IL1RL1 FOS 8131748 251461 Here we show that [Fit-1] is directly *regulated* by the estrogen-inducible transcription factor and that it belongs to the family of delayed early genes . Regulation IL1RL1 GATA1 22865859 2677395 GATA2 is a critical transactivator for the human IL1RL1/ST2 promoter in mast cells/basophils : opposing *roles* for GATA2 and in human [IL1RL1/ST2] gene expression . Regulation IL1RL1 GATA2 22865859 2677396 GATA2 is a critical transactivator for the human IL1RL1/ST2 promoter in mast cells/basophils : opposing *roles* for and GATA1 in human [IL1RL1/ST2] gene expression . Regulation IL1RN ANGPT1 24563688 2919355 The *effects* of extended to the proteins , as Ang1 increased intracellular levels of precursor and mature IL-1ß , and extracellular levels of [IL-1RA] proteins , by up to 4.2- , 5.0- and 4.4-fold respectively , compared to PBS-control . Regulation IL1RN IL1B 14672890 1189150 In addition , IFNbeta enhanced the stimulatory *effect* of on [IL1Ra] production . Regulation IL1RN IL1B 15932509 1414628 This IgA mediated up-regulation of [IL-1RA] is *independent* of the simultaneous up-regulation of release , as shown by blocking the biological activity of IL-1beta with a neutralizing antibody . Regulation IL1RN IL1B 18494930 1917401 In addition , IFN-alpha or IFN-beta significantly enhanced the stimulatory *effect* of on production of [IL-1Ra] . Regulation IL1RN IL1B 7485466 326856 These results are suggestive of an autocrine *role* for cell associated [IL-1Ra] , as well as for IL-1 alpha and , in the regulation of VSMC function . Regulation IL1RN IL1B 9047079 406015 Soluble type II interleukin 1 receptor ( IL-1r II ) and [interleukin 1 receptor antagonist] ( IL-1ra ) *regulate* inflammation by competitively inhibiting the binding of to the signalling IL-1 receptor . Regulation IL1RN IL1B 9353596 461561 1 . [Interleukin-1 receptor antagonist] ( IL-1Ra ) , as well as the gene *response* to immobilization stress ( IMS ) , was examined in the rat brain . Regulation IL1RN IL1B 9949173 589618 The results indicated that both IL-4 and IL-13 amplified the stimulatory *effect* of on production of [IL-1Ra] protein and messenger RNA ( mRNA ) by both human primary hepatocytes and HepG2 cells . Regulation IL1RN TLR7 19922413 2190162 MSK1 regulates the transcription of [IL-1ra] in *response* to activation in macrophages . Regulation IL1RN TNF 19435506 2106940 Quantitative real-time polymerase chain reaction was used to assess the *effect* of or IL-beta stimulation on the expression of matrix metalloproteinase (MMP)-3 , -9 and -13 , TNF-alpha , TNF receptor 1 (TNF-R1) , TNF receptor 2 (TNF-R2) , IL-1alpha , IL-1beta , IL-1 receptor 1 (IL-1R1) and [IL-1 receptor antagonist (IL-1Ra)] . Regulation IL1RN TNF 7882594 298881 The immediate permeability was inhibited by H1-antihistamine but was not *affected* by , by [IL-1ra] , or by depletion of neutrophils . Regulation IL1RN TNF 7882594 298883 The delayed permeability was completely inhibited by either depletion of neutrophils or by and was not *affected* by [IL-1ra] or antihistamine . Regulation IL1RN TNF 8158047 253430 is *involved* in the appearance of [interleukin-1 receptor antagonist] in endotoxemia . Regulation IL1RN TNF 8158047 253433 To assess the *role* of in the appearance of [interleukin-1 receptor antagonist] ( IL-1RA ) in endotoxemia , 4 healthy humans were studied after a bolus intravenous injection of recombinant human TNF ( 50 micrograms/m2 ) . Regulation IL1RN TNF 8331299 223604 The IL-1 alpha and [IL-1ra] *response* to stimulation showed a varied pattern among different keratinocyte strains over 72 h of culture on plain plastic . Regulation IL1RN TNF 9605181 507582 These results provide evidence that IL-8 and were *responsible* for the production of IL-1beta and [IL-1Ra] , and that IL-1beta was responsible for the second phase of IL-1beta and IL-8 production . Regulation IL2 ALOX5 8722494 373697 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL2 ARSA 11238116 790480 In contrast , did not *affect* IL-13 , interferon-gamma , and [IL-2] expression . Regulation IL2 CD14 1714473 163507 engagement did not *affect* [IL-2R] expression or IL-2 synthesis but induced a state of unresponsiveness that was not IL-2 specific ; Regulation IL2 CD14 9300716 453880 Functional *role* for the myeloid differentiation antigen in the activation of human monocytes by [IL-2] . Regulation IL2 DAPK1 18292548 1872955 markedly *affected* T cell proliferation and [IL-2] production . Regulation IL2 EPHB2 17458858 1743186 Syk dependent activation *regulates* [IL-2] and IL-10 production by DC stimulated with zymosan . Regulation IL2 EPHB2 24487322 2913633 Specific and nonspecific stimulation of LLO56 and LLO118 T cells , which transgenically express a TCR specific for the same Listeria monocytogenes epitope , elicited distinct [interleukin 2 (IL-2)] and phosphorylated kinase *responses* , the strength of which was set in the thymus and maintained in the periphery in proportion to the avidity of the binding of the TCR to the self peptide-MHC complex . Regulation IL2 FAS 9469443 485887 We now report that cells infected with T. gondii are resistant to multiple inducers of apoptosis , including *dependent* and Fas independent CTL mediated cytotoxicity , [IL-2] deprivation , gamma irradiation , UV irradiation , and the calcium ionophore beauvericin . Regulation IL2 IL1B 14617515 1200668 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL2 IL1B 2302741 127745 The *effect* of recombinant ( r ) ( rIL-1 beta ) and transforming growth factor-beta ( TGF-beta ) on the production of [interleukin-2 (IL-2)] and interleukin-6 (IL-6) from an antigen-specific ( LBRM-33-1A5 ) and an antigen-nonspecific ( EL-4-NOB-1 ) T-cell line was investigated . Regulation IL2 IL1B 2442261 76938 The *effect* of human recombinant tumor necrosis factor alpha (TNF-alpha) and on [interleukin 2 receptor (IL-2R)] expression on YT cells was examined . Regulation IL2 IL1B 7768308 308384 Based on the utilization of neutralizing antibodies , IL-1 alpha , , and IFN-gamma were not *involved* as soluble mediators during the activation of tumoricidal splenic macrophages by [IL-2] with or without TNF-alpha . Regulation IL2 IL1R2 2969889 95640 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL2 JAG1 11313400 805451 Proliferating gammadelta T cell cultures produced enhanced levels of IFN-gamma and TGF-beta , but not [IL-2] in *response* to the more immunodominant mycobacterial : Depletion of gammadelta T cells from PBMC resulted in an increased Ag-specific proliferation in half the animals tested , indicating a suppressive effect of gammadelta T cells upon other ( alphabeta ) T cell responses . Regulation IL2 MMP28 20639459 2418965 Intracellular calcium flux was augmented in *response* to inhibition or deficiency in the same cells , and [IL-2] production was reduced in CD4 ( + ) and CD8 ( + ) MMP9 ( -/- ) T cells . Regulation IL2 MMP7 20639459 2418980 Intracellular calcium flux was augmented in *response* to inhibition or deficiency in the same cells , and [IL-2] production was reduced in CD4 ( + ) and CD8 ( + ) MMP9 ( -/- ) T cells . Regulation IL2 NEDD9 12486027 1056298 Expression of the association domain mutant exhibits a dominant negative *effect* on both JNK activation and [interleukin-2] production . Regulation IL2 PCSK9 17996668 1821716 had no *effect* on concanavalin A-induced proliferation , [interleukin (IL)-2] secretion and IL-4 secretion in mouse splenocytes . Regulation IL2 STAT4 19001140 1991084 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL2 TLR7 17034424 1683312 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL2 TLR7 18312842 1879706 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL2 TLR7 20471186 2294478 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL2 TNF 11860356 917073 In activated T cells , transcription factors such as the activator protein-1 (AP-1) *regulate* [IL-2] production and production of matrix metalloproteinases , the nuclear factor kappa B (NF-kappa B) is essential for the transcriptional regulation of the proinflammatory cytokines IL-1 , IL-6 , IL-8 and TNF alpha , and nuclear factor of activated T-cells ( NFAT ) is required for the transcriptional regulation of IL-2 , IL-3 , IL-4 , IL-5 , IL-8 , IL-13 , , and GM-CSF . Regulation IL2 TNF 1667651 176618 In contrast to the effects on IFN , IL-1 and , both cannabinoids , had no *effect* on [IL-2] secretion . Regulation IL2 TNF 1705566 152966 The *effect* does not occur at 0 degrees C and can not be induced by [IL-2] , IL-6 , or GM-CSF . Regulation IL2 TNF 1909711 166108 Francisella tularensis induced in vitro gamma interferon , alpha , and [interleukin 2] *responses* appear within 2 weeks of tularemia vaccination in human beings . Regulation IL2 TNF 2442261 76937 The *effect* of human recombinant and interleukin 1 beta (IL-1 beta) on [interleukin 2 receptor (IL-2R)] expression on YT cells was examined . Regulation IL2 TNF 3486658 59985 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL2 TNF 3491252 65990 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL2 TNF 7986155 282358 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL2 TNF 8346413 226971 mediated *regulation* of low-dose [IL-2] activation occurs even at late stages ( effector phase ) of LAK development . Regulation IL2 TNF 8402935 230884 Pivotal *role* of endogenous in the [IL-2-driven] activation and proliferation of the functionally immature NK free subset . Regulation IL2 TNF 9679667 520860 Transgenic expression of cytokines in beta-cells of non-diabetes-prone mice and NOD mice has suggested pathogenic roles for IFN alpha , IFN gamma , [IL-2] and IL-10 in insulin dependent diabetes mellitus ( IDDM ) development , and protective *roles* for IL-4 , IL-6 and . Regulation IL2 TNF 9806041 544699 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL2 TP63 17234427 1664226 Human leukocyte antigen and [interleukin 2] , 10 and <12p40> cytokine *responses* to measles : is there evidence of the HLA effect ? Regulation IL20 ALOX5 8722494 373698 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL20 IL1B 14617515 1200669 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL20 IL1R2 2969889 95642 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL20 STAT4 19001140 1991085 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL20 TLR7 17034424 1683322 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL20 TLR7 18312842 1879716 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL20 TLR7 20471186 2294488 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL20 TNF 3486658 59986 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL20 TNF 3491252 65991 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL20 TNF 7986155 282359 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL20 TNF 9806041 544702 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL21 ALOX5 8722494 373699 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL21 IL1B 14617515 1200670 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL21 IL1B 19682929 2126280 Here , we show that gammadelta T cells express IL-23R and the transcription factor RORgammat and produce IL-17 , [IL-21] , and IL-22 in *response* to and IL-23 , without T cell receptor engagement . Regulation IL21 IL1R2 2969889 95644 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL21 MMP28 16682426 1645749 To investigate whether [IL21] *controls* production by intestinal fibroblasts . Regulation IL21 MMP28 16682426 1645840 These results suggest that fibroblasts are a potential target of [IL21] in the gut and that IL21 *controls* secretion by fibroblasts . Regulation IL21 MMP7 16682426 1645764 To investigate whether [IL21] *controls* production by intestinal fibroblasts . Regulation IL21 MMP7 16682426 1645855 These results suggest that fibroblasts are a potential target of [IL21] in the gut and that IL21 *controls* secretion by fibroblasts . Regulation IL21 STAT4 19001140 1991086 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL21 TLR7 17034424 1683332 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL21 TLR7 18312842 1879726 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL21 TLR7 20471186 2294498 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL21 TNF 3486658 59987 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL21 TNF 3491252 65992 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL21 TNF 7986155 282360 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL21 TNF 9806041 544705 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL22 ALOX5 8722494 373682 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL22 IL1B 14617515 1200653 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL22 IL1B 19682929 2126274 Here , we show that gammadelta T cells express IL-23R and the transcription factor RORgammat and produce IL-17 , IL-21 , and [IL-22] in *response* to and IL-23 , without T cell receptor engagement . Regulation IL22 IL1R2 2969889 95556 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL22 RORC 19578368 2111598 Downregulation of either the aryl hydrocarbon receptor (AHR) or the transcription factor by RNA mediated interference *affected* [IL-22] production , whereas IL-17 production was affected only by downregulation of RORC by RNA mediated interference . Regulation IL22 STAT4 19001140 1991069 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL22 TLR7 17034424 1683162 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL22 TLR7 18312842 1879556 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL22 TLR7 20471186 2294328 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL22 TNF 21393631 2401085 T ( h ) 22 cells produce [IL-22] in *response* to IL-6 and , particularly in the skin , whereas ?d T cells produce IL-22 in response to IL-23 , particularly in the lung . Regulation IL22 TNF 3486658 59970 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL22 TNF 3491252 65975 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL22 TNF 7986155 282343 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL22 TNF 9806041 544654 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL23A CD14 15516327 1328552 LPS induced increase of [IL-23] and IL-12 subunits expression was *dependent* , while CD14 was not involved in SAC induced p19 transcription . Regulation IL23A EPHB2 15626475 1362099 differentially *regulate* expression of [IL-23 p19] compared with p40 and IFN-beta in Theiler 's virus infected RAW264.7 cells . Regulation IL23A IL1B 17569750 1774220 To explore the source of the p19 subunit of interleukin-23 (IL-23) in joints with rheumatoid arthritis ( RA ) , the *effects* of and tumour necrosis factor (TNF)-alpha on [IL-23] gene expression in RA fibroblast-like synoviocytes and the effect of IL-23 on proinflammatory cytokines . Regulation IL23A IL1B 17569750 1774231 *regulates* [IL-23 p19] expression via NF-kappaB and AP-1 pathways . Regulation IL23A PTGER2 23337716 2753644 These results can be explained by differential *regulation* of the common subunit , IL-12p40 , and [IL-23p19] , by and EP(4) . Regulation IL23A RORC 23469228 2750329 Variable expression of CD161 , IL-23R and *affects* [IL-23] responsiveness and contributes to the inter-individual susceptibility to IL-23 mediated defenses and inflammatory processes . Regulation IL23A TLR7 17897860 1811293 TLR3 and are *involved* in expression of [IL-23] subunits while TLR3 but not TLR7 is involved in expression of IFN-beta by Theiler 's virus infected RAW264.7 cells . Regulation IL23A TLR7 18276743 2010208 *dependent* induction of p19 , p40 and bioactive [IL23] was determined in RA synovial fibroblasts ( RASF ) , monocytes and monocyte derived dendritic cells ( MDDCs ) by real-time PCR and reverse transcriptase ( RT ) -PCR , Western blot and functional assays . Regulation IL23A TLR7 18802116 1964990 Notably , [IL-23] production in *response* to single ligands was inhibited by IL-4 . Regulation IL23A TLR7 20408896 2300636 In the present study , we examined the effect of prostaglandin E ( 2 ) ( PGE ( 2 ) ) treatment of DCs during differentiation on IL-12 and [IL-23] production in *response* to stimulation . Regulation IL23A TLR7 20483758 2270104 Human intestinal lamina propria CD1c+ dendritic cells display an activated phenotype at steady state and produce [IL-23] in *response* to stimulation . Regulation IL23A TLR7 23880957 2825516 The *effect* of proinflammatory cytokines [ tumor necrosis factor a (TNFa) and IL-17 ] and ligands [ poly ( I:C ) and lipopolysaccharide (LPS) ] on IL-17R expression and IL-12 and [IL-23] production was studied in osteoarthritis ( OA ) - and rheumatoid arthritis ( RA ) -FLS , involved in Th1/Th17 differentiation . Regulation IL23A TLR7 23967307 2832738 In this study , our data suggest that Tim-3 and [IL-12/IL-23] gene transcriptions are *regulated* by enhanced or silenced Gal-9 expression within monocytes through synergizing with signaling . Regulation IL23A TNF 17569750 1774219 To explore the source of the p19 subunit of interleukin-23 (IL-23) in joints with rheumatoid arthritis ( RA ) , the *effects* of IL-1beta and on [IL-23] gene expression in RA fibroblast-like synoviocytes and the effect of IL-23 on proinflammatory cytokines . Regulation IL24 ALOX5 8722494 373680 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL24 IL1B 14617515 1200651 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL24 IL1R2 2969889 95552 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL24 STAT4 19001140 1991067 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL24 TLR7 17034424 1683141 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL24 TLR7 18312842 1879536 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL24 TLR7 20471186 2294308 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL24 TNF 24211183 2868572 Here we report that the development of psoriasis-like skin inflammation in mice with epidermis-specific inhibition of the transcription factor NF-?B was triggered by *dependent* upregulation of [interleukin-24 (IL-24)] and activation of signal transducer and activator of transcription 3 ( STAT3 ) signaling in keratinocytes . Regulation IL24 TNF 3486658 59968 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL24 TNF 3491252 65973 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL24 TNF 7986155 282314 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL24 TNF 9806041 544648 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL25 ALOX5 8722494 373681 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL25 IL1B 14617515 1200652 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL25 IL1R2 2969889 95554 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL25 STAT4 19001140 1991068 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL25 TLR7 17034424 1683152 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL25 TLR7 18312842 1879546 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL25 TLR7 20471186 2294318 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL25 TNF 20944558 2389299 [Interleukin-25] production is differently *regulated* by and TGF-ß1 in the human gut . Regulation IL25 TNF 20944558 2389305 Data show that [IL-25] production is differently *regulated* by and TGF-ß1 in the human gut . Regulation IL25 TNF 3486658 59969 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL25 TNF 3491252 65974 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL25 TNF 7986155 282342 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL25 TNF 9806041 544651 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL26 ALOX5 8722494 373686 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL26 IL1B 14617515 1200657 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL26 IL1R2 2969889 95564 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL26 STAT4 19001140 1991073 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL26 TLR7 17034424 1683202 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL26 TLR7 18312842 1879596 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL26 TLR7 20471186 2294368 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL26 TNF 3486658 59974 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL26 TNF 3491252 65979 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL26 TNF 7986155 282347 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL26 TNF 9806041 544666 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL27 ALOX5 8722494 373687 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL27 IL1B 14617515 1200658 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL27 IL1R2 2969889 95566 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL27 STAT4 19001140 1991074 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL27 TLR7 17034424 1683212 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL27 TLR7 18312842 1879606 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL27 TLR7 20471186 2294378 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL27 TNF 3486658 59975 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL27 TNF 3491252 65980 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL27 TNF 7986155 282348 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL27 TNF 9806041 544669 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL2RA IL1B 9402849 469568 Thus , circulating could be *involved* in the expression of [CD25] on CD4+ T-PBL and favors the generation of memory CD4+ T-PBL . Regulation IL2RA MAP2K6 12039916 949547 However , inhibition only partially abrogated the EtxB mediated up-regulation of MHC class II expression and did not *affect* [CD25] expression -- findings suggesting that additional pathways downstream of PI3-kinase are involved . Regulation IL2RA TLR7 19843574 2187461 Although signaling through certain TLRs is known to modulate the function of T lymphocytes , the *effect* of stimulation on CD4 ( + ) [CD25] ( + ) T ( reg ) cell activity has not yet been elucidated . Regulation IL2RA TNF 12221281 987611 *regulation* of [CD4+CD25+] T cell levels in NOD mice . Regulation IL2RA TNFSF10 19008314 2047183 In the present study , we specifically examined *effects* on CD4 ( + ) [CD25] ( + ) regulatory T cells . Regulation IL2RB EPHB2 24026251 2846123 These data suggest that ethanol increases p75NTR expression , and CK2 and signaling inversely *regulate* Sp1 mediated [p75NTR] expression in ethanol treated neuroblastoma cells . Regulation IL2RG TGM2 16382148 1505653 Here , we report that the Ca2+ dependent protein cross linking enzyme is *involved* in THG induced p40 and [p64] formation by catalyzing caspase 3 cross linking reactions , thereby inactivating caspase 3 and apoptosis in Bax-deficient cells . Regulation IL3 ALOX5 8722494 373700 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL3 IL1B 14617515 1200671 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL3 IL1B 8428397 212458 In addition , the results showed that preterm serum has a lower stimulatory effect on production and an inhibitory *effect* on [IL-3-LA] secretion by PBMC of adult controls , in comparison with maternal and adult sera . Regulation IL3 IL1R2 2969889 95646 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL3 STAT4 19001140 1991087 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL3 TLR7 17034424 1683342 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL3 TLR7 18312842 1879736 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL3 TLR7 20471186 2294508 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL3 TNF 1693526 132755 The potentiating *effect* of on [IL-3-] and GM-CSF dependent growth of CD34+ HPC is also observed in day 7 colony assays . Regulation IL3 TNF 3486658 59988 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL3 TNF 3491252 65993 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL3 TNF 3495589 73694 Disparate *effects* of and tumor necrosis factor-beta/lymphotoxin on [hematopoietic growth factor] production and neutrophil adhesion molecule expression by cultured human endothelial cells . Regulation IL3 TNF 3495589 73695 We compared the *effect* of purified recombinant human and TNF-beta on neutrophil adhesion molecule expression and [hematopoietic growth factor] production by cultured human umbilical vein endothelial cells . Regulation IL3 TNF 7545455 318548 *Regulation* of [interleukin-3 receptor (IL-3R)] gene expression by was investigated using an IL-3 dependent CD34 positive hematopoietic cell line ( KMT2 ) and a human megakaryocytic cell line ( CMK ) . Regulation IL3 TNF 7986155 282361 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL3 TNF 9122614 423988 *regulates* GM-CSF- , [IL-3-] or M-CSF induced Fc epsilon RII/CD23 gene expression and soluble Fc epsilon RII release by human monocytes . Regulation IL3 TNF 9122614 423990 The authors examined the regulatory *effects* of on granulocyte macrophage colony stimulating factor ( GM-CSF ) - , [interleukin-3 (IL-3)-] or macrophage colony stimulating factor ( M-CSF ) -induced gene expression of the low affinity receptor for IgE ( Fc epsilon RII ) on human monocytes and GM-CSF- , IL-3- or M-CSF induced soluble Fc epsilon RII ( sFc epsilon RII ) release from monocytes . Regulation IL3 TNF 9122614 423999 These results suggest that *dependent* reduction of GM-CSF- , [IL-3-] or M-CSF induced Fc epsilon RII expression on the surface of monocytes resulted , at least in part , from the suppression of Fc epsilon RII mRNA and the enhancement of sFc epsilon RII release . Regulation IL3 TNF 9806041 544708 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL31 ALOX5 8722494 373688 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL31 IL1B 14617515 1200659 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL31 IL1R2 2969889 95568 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL31 STAT4 19001140 1991075 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL31 TLR7 17034424 1683222 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL31 TLR7 18312842 1879616 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL31 TLR7 20471186 2294388 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL31 TNF 3486658 59976 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL31 TNF 3491252 65981 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL31 TNF 7986155 282349 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL31 TNF 9806041 544672 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL32 ALOX5 8722494 373685 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL32 IL1B 14617515 1200656 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL32 IL1B 18239058 1877026 Human pancreatic periacinar myofibroblasts expressed [IL-32alpha] in *response* to , TNF-alpha , and IFN-gamma . Regulation IL32 IL1R2 2969889 95562 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL32 STAT4 19001140 1991072 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL32 TLR7 17034424 1683192 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL32 TLR7 18312842 1879586 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL32 TLR7 20471186 2294358 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL32 TNF 20615213 2321726 The [IL-32a] isoform was expressed intracellularly in *response* to and poly I:C and not released in culture supernatants . Regulation IL32 TNF 21152864 2373370 Human colonic SEMFs expressed [IL-32a] in *response* to IL-1ß and . Regulation IL32 TNF 3486658 59973 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL32 TNF 3491252 65978 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL32 TNF 7986155 282346 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL32 TNF 9806041 544663 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL33 ALOX5 8722494 373684 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL33 IL1B 14617515 1200655 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL33 IL1R2 2969889 95560 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL33 STAT4 19001140 1991071 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL33 TLR7 17034424 1683182 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL33 TLR7 18312842 1879576 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL33 TLR7 20471186 2294348 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL33 TLR7 22634618 2615110 Transcriptional *regulation* of murine [IL-33] by TLR and agonists . Regulation IL33 TNF 20405148 2327220 IL-1ß and did not *affect* [IL-33] expression in intestinal epithelial cell lines ( HT-29 and Caco-2 cells ) . Regulation IL33 TNF 22277940 2580173 In addition , skin fibroblasts , HaCaT keratinocytes , primary macrophages , and HUVEC endothelial cells efficiently produced [IL-33] in *response* to the combined stimulation of and IFN-? , which was further enhanced by a mimetic of double stranded RNA . Regulation IL33 TNF 22673732 2681614 *Regulation* of [IL-33] expression by IFN-? and in normal human epidermal keratinocytes . Regulation IL33 TNF 24522896 2924171 [IL-33] is *regulated* by in normal and psoriatic skin . Regulation IL33 TNF 24522896 2924174 In particular , we can assess that [IL-33] is *regulated* by in normal and psoriatic skin . Regulation IL33 TNF 3486658 59972 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL33 TNF 3491252 65977 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL33 TNF 7986155 282345 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL33 TNF 9806041 544660 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL33 TNFSF10 22961755 2701850 but not FasL and TNFa , *regulates* [IL-33] expression in murine hepatocytes during acute hepatitis . Regulation IL33 TNFSF10 22961755 2701851 Finally , the *effect* of on [IL-33] expression was assessed in primary cultured murine hepatocytes . Regulation IL34 ALOX5 8722494 373689 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL34 IL1B 14617515 1200660 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL34 IL1R2 2969889 95570 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL34 STAT4 19001140 1991076 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL34 TLR7 17034424 1683232 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL34 TLR7 18312842 1879626 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL34 TLR7 20471186 2294398 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL34 TNF 3486658 59977 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL34 TNF 3491252 65982 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL34 TNF 7986155 282350 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL34 TNF 9806041 544675 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL37 ALOX5 8722494 373683 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL37 IL1B 14617515 1200654 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL37 IL1R2 2969889 95558 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL37 STAT4 19001140 1991070 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL37 TLR7 17034424 1683172 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL37 TLR7 18312842 1879566 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL37 TLR7 20471186 2294338 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL37 TNF 3486658 59971 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL37 TNF 3491252 65976 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL37 TNF 7986155 282344 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL37 TNF 9806041 544657 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL3RA TNF 7545455 318550 The *effects* of on [IL-3R] mRNA expression were completely different in a primitive and in a more committed hematopoietic cell line . Regulation IL4 ALOX5 8722494 373701 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL4 ARSA 11238116 790487 The inhibitory *effect* of on [IL-4] transcription was not mediated by decreased nuclear expression of the known salicylate target nuclear factor (NF)-kappaB and was accompanied by reduced binding of an inducible factor to an IL-4 promoter region upstream of , but not overlapping , the NF of activated T cells- and NF-kappaB binding P1 element . Regulation IL4 ARSG 24324328 2880250 *regulates* the expression of CaBP9k and [IL-4] receptor genes , and ORZ regulates the expression of the CaBP9k gene , while GABA at 100 mg/kg regulates the expression of the HSP70 gene . Regulation IL4 CAPN8 11119528 768443 On the other hand , spleen cells of immunized mice showed only faint [interleukin-4] production in *response* to in vitro , suggesting that immunization with r-calpain alters the Th1-Th2 balance in murine hosts even during a Th2 promoting S. japonicum infection . Regulation IL4 COL17A1 17973812 1820561 The degree of improvement in the clinical symptoms , serum [interleukin (IL)-4] , IL-5 , and plasma RANTES concentrations , as well as the *results* of indirect immunofluorescence and enzyme linked immunosorbent assay index values , were compared before and after the 7-day drug administration . Regulation IL4 EPHB2 11880312 919372 IL-13 and [IL-4] cause eotaxin release in human airway smooth muscle cells : a *role* for . Regulation IL4 EPHB2 12594266 1060826 In this study , we show that *plays* a critical role in [IL-4] expression during TCR induced Th differentiation of naive CD4 ( + ) T cells . Regulation IL4 EPHB2 12594266 1060839 In addition , these data suggest that TCR induced activation is *involved* in the regulation of [IL-4] expression by altering the composition of the AP-1 complex and its subsequent DNA binding activity . Regulation IL4 EPHB2 21989417 2636385 A novel mechanism for *dependent* regulation of [IL4] transcription during human Th2-cell differentiation . Regulation IL4 IL1B 12880609 1115760 stimulation increased IL-6 and IL-8 , but did not *affect* [IL-4] and IL-10 production . Regulation IL4 IL1B 14617515 1200672 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL4 IL1R2 2969889 95648 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL4 JAG1 21490151 2422916 In this article , we demonstrate that LT acts as a highly effective adjuvant when administered parenterally , promoting Ag-specific IL-17 , as well as IFN-? , [IL-4] , and IL-10 production in *response* to coadministered . Regulation IL4 PCSK9 17996668 1821717 had no *effect* on concanavalin A-induced proliferation , interleukin (IL)-2 secretion and [IL-4] secretion in mouse splenocytes . Regulation IL4 RORC 24211040 2879428 The limited expansion of human Th17 cells is related to the *dependent* up-regulation of the [interleukin (IL)-4] induced gene 1 ( IL4I1 ) , which encodes for a l-phenylalanine oxidase , that has been shown to down-regulate CD3? expression in T cells . Regulation IL4 STAT4 19001140 1991088 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL4 STK39 8258686 238764 Taken together , our data demonstrate that activation of both a and a tyrosine kinase is *involved* in the IL-2 , [IL-4] , and IL-6-stimulation of IgM secretion by SKW6.4 cells and activation of the same or a similar serine/threonine protein kinase is an early step in the signal transduction pathway used by these cytokines . Regulation IL4 TLR7 17034424 1683352 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL4 TLR7 18312842 1879746 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL4 TLR7 20471186 2294518 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL4 TNF 11000288 734472 In contrast , favoured expression of smaller tenascin-C transcripts , and [IL-4] equally *affected* the expression of large and small tenascin-C mRNAs . Regulation IL4 TNF 11891780 920517 Of note , we present evidence that may be involved in regulating RANTES and MIP-1alpha , and that [IL-4] may be *involved* in regulating MCP-1 . Regulation IL4 TNF 15553672 1338694 Two out of 6 pts who experienced stable disease after the treatment had high IFN-gamma and responses and no TGF-beta1 or [IL-4] *response* . Regulation IL4 TNF 20798517 2313711 The results showed that induced up to 2.7-fold increase in IL-4 , but not IL-12 release from P815 cells , and PAR-2 antagonist peptide FSLLRY-NH ( 2 ) and PAR-4 antagonist peptide trans-cinnamoyl ( tc ) -YPGKF-NH ( 2 ) did not *affect* TNF induced [IL-4] release . Regulation IL4 TNF 3486658 59989 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL4 TNF 3491252 65994 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL4 TNF 7986155 282362 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL4 TNF 8064732 268855 Piroxicam treatment resulted in elevation of levels of IL-2 , depression of IL-1 , IL-6 , and IFN-gamma , and no consistent *effect* on [IL-4] . Regulation IL4 TNF 8280160 240560 In the present study , we have examined the *regulation* of [IL-4R] by . Regulation IL4 TNF 8871669 389632 Addition of an Ab to IL-10 suggested that the stimulatory effects of LPS on p75 receptor expression were due , at least in part , to LPS stimulation of IL-10 production and that [IL-4] *acted* , in part , by decreasing IL-10 production . Regulation IL4 TNF 9806041 544711 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL4 TNF 9927530 588648 We investigated the *role* of in the regulation of MHC class II antigens and cytokine mRNA expression of TNF , interferon-gamma (IFN) , IL-2 , [IL-4] , and IL-10 in cardiac allografts to elucidate its immunological mechanism . Regulation IL5 ALOX5 8722494 373702 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL5 COL17A1 17973812 1820562 The degree of improvement in the clinical symptoms , serum interleukin (IL)-4 , [IL-5] , and plasma RANTES concentrations , as well as the *results* of indirect immunofluorescence and enzyme linked immunosorbent assay index values , were compared before and after the 7-day drug administration . Regulation IL5 EPHB2 9533450 496958 However , the production of IL-3 and IL-4 was only partially dependent upon ERK activation , whereas [IL-5] , IL-10 , IFN-gamma and GM-CSF production was severely *affected* by diminished activation . Regulation IL5 IL1B 14617515 1200673 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL5 IL1R2 2969889 95650 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL5 STAT4 19001140 1991089 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL5 TLR7 17034424 1683362 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL5 TLR7 18312842 1879756 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL5 TLR7 20471186 2294528 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL5 TNF 21402950 2411944 from inflammatory dendritic cells (DCs) *regulates* lung [IL-17A/IL-5] levels and neutrophilia versus eosinophilia during persistent fungal infection . Regulation IL5 TNF 3486658 59990 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL5 TNF 3491252 65995 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL5 TNF 7986155 282363 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL5 TNF 9806041 544714 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL6 ADRB2 11096136 755713 activation *regulates* tumour necrosis factor (TNF)-alpha and [interleukin-6 (IL-6)] production in cultured renal cells . Regulation IL6 ADRB2 9688336 521948 *Regulation* of tumour necrosis factor and [interleukin-6] gene transcription by in the rat astrocytes . Regulation IL6 ALOX5 8722494 373703 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL6 ARSA 18187132 1890054 To assess the *effects* of on glutamate and [interleukin-6 (IL-6)] release in the striatum of rats suffering from cerebral ischemia , we used the microdialysis technique with probes implanted 2 h prior to stroke onset . Regulation IL6 CAPN8 15985533 1428637 We observed a smoke extract induced , *dependent* degradation of the intracellular form of platelet-endothelial cell adhesion molecule 1/CD31 , as well as a release of P-selectin/CD62P , [IL-6] , and IL-8 from endothelial cells into the supernatant . Regulation IL6 CD14 10093540 560668 To clarify the mechanism of the lipopolysaccharide induced modulation of the function of gingival fibroblasts , we investigated the *effect* of on [interleukin 6 (IL-6)] production on human gingival fibroblasts in vitro . Regulation IL6 CD14 11485266 844853 These results suggest the [IL-6] expression by pulp cell cultures is *dependent* and regulated at the transcriptional level , and a combined treatment with immunoregulatory cytokines may be effective for control of pulpal inflammation due to P. intermedia LPS . Regulation IL6 CD14 12193231 981026 Thereafter , the *effects* of LPS , soluble ( sCD14 ) and LPS binding protein (LBP) on the release of [interleukin-6 (IL-6)] and IL-8 were studied . Regulation IL6 CD14 12885389 1116640 Furthermore the *involvement* of in activation of [interleukin-6] release is investigated . Regulation IL6 CD14 7681082 214207 *Involvement* of in lipopolysaccharide induced tumor necrosis factor-alpha , [IL-6] and IL-8 release by human monocytes and alveolar macrophages . Regulation IL6 CD14 7681082 214213 We conclude that is *involved* in LPS induced release of TNF-alpha , [IL-6] , and IL-8 by monocytes and alveolar macrophages and that this receptor appears to be able to recognize LPS directly in the absence of serum . Regulation IL6 EDN2 8587460 341723 We investigated the *effects* of and thrombin on the production of [interleukin 6 (IL-6)] in human umbilical vein endothelial cells ( HUVECs ) . Regulation IL6 EPHB2 17761160 1801743 These results suggest that and calcineurin are cooperatively *involved* in UTP induced [IL-6] production . Regulation IL6 EPHB2 19299480 2106084 In the present study , we demonstrate that CGRP is involved in morphine tolerance by differentially regulating the *dependent* up-regulation of IL-1beta , TNF-alpha , and microsomal prostaglandin E synthase-1 ( mPGES-1 ) in astrocytes and p38 dependent up-regulation of [IL-6] in microglia in the rat spinal cord . Regulation IL6 EPHB2 20511709 2270509 Both LPS and GA stimulated the production of [IL-6] , IL-10 , IL12p70 and TNFalpha in a p38- and/or *dependent* manner . Regulation IL6 F2R 12506061 1038288 HCE-T expression of cytokines ( [IL-6] , IL-8 , and TNFalpha ) in *response* to activation of and -2 was measured by quantitative RT-PCR and ELISA . Regulation IL6 F2R 18062909 1867677 By using pharmacological inhibitors or activators or genetic inhibition by the protease activated receptor (PAR) , siRNA revealed that the receptor but not other PAR receptors is *involved* in thrombin mediated up-regulation of [IL-6] . Regulation IL6 F2R 24449213 2923097 In contrast , neither thrombin inhibition nor deficiency in nonhematopoietic cells *affected* plasma levels of [IL-6] in sickle mice . Regulation IL6 FUT4 10440571 635325 We investigated the *effect* of , a serine protease inhibitor , on the production of pro-inflammatory cytokines , [interleukin-6 (IL-6)] and interleukin-8 (IL-8) , by monocytes stimulated with lipopolysaccharide (LPS) . Regulation IL6 HBEGF 17822789 1817477 First , we examined the *effect* of on [interleukin-6 (IL-6)] mRNA expressions , since IL-6 have been implicated in the regulation of STAT3 activation . Regulation IL6 IL1B 10478575 643373 In this study , we examined the *effect* of adrenaline and on [interleukin-6] secretion from cultured murine neurohypophyseal cells . Regulation IL6 IL1B 10669630 665767 Adhesion of monocyte very late antigen-4 to endothelial vascular cell adhesion molecule-1 induces *dependent* expression of [interleukin-6] in endothelial cells . Regulation IL6 IL1B 10728932 579468 *Effects* of TNF-alpha and on mucin , lysozyme , [IL-6] and IL-8 in passage-2 normal human nasal epithelial cells . Regulation IL6 IL1B 10929868 719761 These results indicate that while MG-63 cells express functional C5aRs , the synergistic *effect* of C5a and on osteoblast [IL-6] production is probably controlled by post-receptor signaling events . Regulation IL6 IL1B 11028561 739582 The *effect* of on AP-1 activity in the enterocyte and the potential role of AP-1 in enterocyte [IL-6] production are not known . Regulation IL6 IL1B 11028561 739593 These results suggest that the AP-1 family of transcription factors is activated by in human enterocytes and that AP-1 may at least in part *regulate* [IL-6] production in these cells . Regulation IL6 IL1B 11069090 747726 Moreover , the induction of [IL-6] was also *independent* of endogenous , as macrophages isolated from IL-1beta deficient mice produced normal amounts of IL-6 after stimulation with IL-18 . Regulation IL6 IL1B 11093146 754951 IL-1L1 did not stimulate IL-6 production from primary human fibroblasts or human umbilical vein endothelial cells nor did it block the IL-1alpha or *dependent* activation of [IL-6] expression . Regulation IL6 IL1B 11104703 756497 In related experiments , the protein tyrosine phosphatase inhibitor Na ( 3 ) VO ( 4 ) also antagonized the inhibitory *effect* of on the activation of STAT1 by [IL-6] . Regulation IL6 IL1B 11446462 835395 Regulatory *role* of in the expression of [IL-6] and IL-8 in human corneal epithelial cells during Pseudomonas aeruginosa colonization . Regulation IL6 IL1B 11450697 836636 In contrast to these findings , the stimulatory *effects* of PTH , TNF-alpha , and on the [IL-6] promoter expression were enhanced by staurosporine . Regulation IL6 IL1B 11478844 842086 Involvement of PKC-beta in PTH , TNF-alpha , and *effects* on [IL-6] promoter in osteoblastic cells and on PTH stimulated bone resorption . Regulation IL6 IL1B 11642733 872253 TGF-beta1 and [IL-6] expression in rat pineal gland is *regulated* by norepinephrine and . Regulation IL6 IL1B 12010575 941241 Reporter gene assays in immortalized chondrocytes , C-20/A4 , consistently showed increased sIL-1Ra promoter activity in *response* to and [IL-6] . Regulation IL6 IL1B 12045890 895171 The *role* of in the regulation of IL-8 and [IL-6] in human corneal epithelial cells during Pseudomonas aeruginosa colonization . Regulation IL6 IL1B 12045890 895175 The purpose of this study was to investigate whether *regulates* the expression of [IL-6] and IL-8 in human corneal epithelial cells during Pseudomonas aeruginosa colonization . Regulation IL6 IL1B 12096891 961160 The present study tested whether prior exposure to inescapable tailshock ( IS ) alters the , tumor necrosis factor (TNF)-alpha , or [IL-6] *response* to an injection of bacterial endotoxin ( lipopolysaccharide ; Regulation IL6 IL1B 12527330 1048286 Rhein partially reversed the *effect* of on TIMP-1 and NO production , had no effect on AGG , [IL-6] and MIP-1beta production , but up-regulated the IL-1beta stimulated PGE ( 2 ) production . Regulation IL6 IL1B 12676746 1076882 We tested the hypothesis that [IL-6] production in muscle cells is *regulated* by and that mitogen activated protein (MAP) kinase signaling and NF-kappaB activation are involved in IL-1beta induced IL-6 production . Regulation IL6 IL1B 12889600 1117209 To study TGF-beta , TNF-alpha and *regulation* of [IL-6] and IL-11 production in human MDA-MB-231 breast cancer cells , we established single cell clones stably expressing dominant negative ( DN ) forms of the mitogen activated protein kinases p38 ( p38/AF ) or ERK1 ( ERK1K71R ) . Regulation IL6 IL1B 1311232 178766 Thus , the adrenal may be an important convergence point between the immune and endocrine systems , and because [IL-6] release is *regulated* by IL-1 alpha , , ACTH , and angiotensin II , and this cytokine stimulates corticosterone release , IL-6 may play an important paracrine role in integrating the signals derived from these systems . Regulation IL6 IL1B 1393463 198826 The systemic and [IL-6] *response* to surgical trauma increased with the severity of the surgical insult . Regulation IL6 IL1B 1402392 199582 Tumor cell [IL-6] gene expression is *regulated* by and TNF alpha : proposed feedback mechanisms induced by the interaction of tumor cells and macrophages . Regulation IL6 IL1B 1417523 201633 The finding that [IL-6] is produced by PDL cells and is *regulated* by has revealed a potentially important mechanism for controlling alveolar bone resorption . Regulation IL6 IL1B 14617515 1200674 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL6 IL1B 15000862 1216965 Lipoxin A4 ( LXA4 ) and transforming growth factor beta 2 ( TGF-beta 2 ) , mediators with potential anti-inflammatory activities , were tested to determine how they affect *dependent* release of [IL-6] and MMPs in human fibroblast like synoviocytes . Regulation IL6 IL1B 15316244 1286189 The *effects* of and LPC on [IL-6] release from glioma cells are effectively antagonized by the inhibitory neurotransmitters SRIF and GABA . Regulation IL6 IL1B 15373762 1297877 The addition of IL-1Ra neutralized the *effects* of on [IL-6] secretion . Regulation IL6 IL1B 1541815 180864 No detectable circulating TNF-alpha , , or [IL-6] *response* was induced by either IL-8 administration regimen . Regulation IL6 IL1B 16002736 1431022 Dexamethasone completely blocked the *effect* of on [IL-6] expression . Regulation IL6 IL1B 16109400 1448472 The *effect* of and interferon-gamma on [interleukin-6] and nitric oxide secretion was investigated in pituicytes cultured for 14 days . Regulation IL6 IL1B 16354411 1492519 Licochalcone A ( IC50 15.0 nM ) inhibited PGE2 production , but not [IL-6] and IL-8 production , in *response* to . Regulation IL6 IL1B 16407046 1513313 We investigated whether HDSMCs are capable of expressing and releasing MCP-1 , [IL-6] and SCF in *response* to IL-4 , IL-13 , and tumor necrosis factor-alpha . Regulation IL6 IL1B 16435581 1495238 When added to HGFs , had a stimulatory *effect* on the production of [IL-6] , and this effect was significantly reduced by SB203580 , a specific p38 MAPK inhibitor . Regulation IL6 IL1B 1649133 160902 These results suggest that IL-1 has differing effects on the release of mediators by synovial cells and chondrocytes and that these cells also vary in their *responses* to and [IL-6] . Regulation IL6 IL1B 16584593 1544095 there were not *effects* of expression on expressions of [IL-6] and SCF . Regulation IL6 IL1B 17201586 1663173 Our aim was to find out whether , along with the activation of hypothalamo-pituitary-adrenocortical ( HPA ) axis and prolactin (PRL) , the acute systemic enhancement of *affects* its own production in the hypothalamus as well as that of [IL-6] . Regulation IL6 IL1B 1730872 181335 We have previously reported that transforming growth factor-beta inhibits [IL-6] production in *response* to . Regulation IL6 IL1B 17698652 1782301 Here , it is reported that both wild-type and mutant IE2p86 can block activation of the [IL-6] promoter in *response* to . Regulation IL6 IL1B 18248759 1877161 Uropathogenic E. coli prevented [interleukin-6] secretion in *response* to non-pathogenic E. coli and a panel of Toll-like receptor agonists , as well as to , but not to tumor necrosis factor alpha . Regulation IL6 IL1B 18297990 1840042 No stimulatory *effect* of on [IL-6] was observed : IL-1beta was unchanged while IL-6 levels were increased after treatment . Regulation IL6 IL1B 18502965 1917761 [IL-6-type] cytokine expression and *regulation* by and tumor necrosis factor-alpha (TNF-alpha) were studied in fibroblasts from the non inflamed gingiva of healthy individuals . Regulation IL6 IL1B 18784630 1969249 In addition , IL-6 secretion from AF cells in response to TNF-alpha was up-regulated by coculture , however , [IL-6] secretion in *response* to was downregulated in a dose dependent manner . Regulation IL6 IL1B 1937867 170367 We compared the *effects* of platelet activating factor (PAF) , and polyriboinositic-polyribocytidylic acid ( poly-I:C ) on [IL-6] production by confluent L929 mouse fibroblasts . Regulation IL6 IL1B 19580863 2142571 *Role* of and COX2 in silica induced [IL-6] release and loss of pneumocytes in co-cultures . Regulation IL6 IL1B 19697035 2258171 The level of [IL-6] expression was strongly increased in both FLSs and THP-1 macrophages in *response* to and TNF-alpha , but the level by TNF-alpha was less than that by IL-1beta . Regulation IL6 IL1B 20227492 2244026 A new *regulation* of [IL-6] production in adult cardiomyocytes by beta-adrenergic and receptors and induction of cellular hypertrophy by IL-6 trans signalling . Regulation IL6 IL1B 20525168 2284207 Functional studies indicated that induced miR-146a expression does not negatively *regulate* [IL-6] and IL-8 release or basal proliferation . Regulation IL6 IL1B 21993958 2493548 The contaminating ( 1,3 ) -beta-glucans enhanced the [MAT/IL-6] *response* to endotoxin , but not that of . Regulation IL6 IL1B 2302741 127749 The *effect* of recombinant ( r ) ( rIL-1 beta ) and transforming growth factor-beta ( TGF-beta ) on the production of interleukin-2 (IL-2) and [interleukin-6 (IL-6)] from an antigen-specific ( LBRM-33-1A5 ) and an antigen-nonspecific ( EL-4-NOB-1 ) T-cell line was investigated . Regulation IL6 IL1B 24279177 2876958 On days 12 to 13 of pregnancy myometrial release of E1 was markedly increased in *response* to and [IL6] . Regulation IL6 IL1B 2786697 114806 Connective tissue type cells ( synoviocytes ) cultured from RA synovial tissue produce [IL-6] in *response* to , and IL-6 formation is increased by TGF-beta . Regulation IL6 IL1B 2809510 121413 Although bacterial endotoxin/lipopolysaccharide is a potent stimulus for the synthesis and release of IL-1 and IL-6 in vitro , specific neutralization of cachectin/TNF in vivo with mAb pretreatment significantly attenuated both the and the [IL-6] *responses* despite fulminant overwhelming bacteremia . Regulation IL6 IL1B 7502703 327013 However , T3 potentiated the stimulatory *effect* of on [IL-6] production in a dose dependent manner . Regulation IL6 IL1B 7502703 327015 One micromolar indomethacin significantly , but not completely , inhibited the effect of , as well as the combined *effect* of IL-1 beta and T3 on resorption and [IL-6] production , indicating the involvement of prostaglandins in these actions . Regulation IL6 IL1B 7506738 244462 However , inhibition of the cAMP pathway effector , protein kinase A , did not reduce the induction of astrocyte [IL-6] gene expression in *response* to or TNF-alpha , and an ELISA for cAMP detected only very small increases in cAMP synthesis in response to these cytokines . Regulation IL6 IL1B 7722482 301841 The *involvement* of protein kinase C and its interaction with in the control of [interleukin 6] release by cortical astrocytes was studied . Regulation IL6 IL1B 7850809 294327 Collectively , additional factor ( s ) besides IL-1Ra and may *control* [IL-6] and some other cachexigenic factor production , thereby causing cachexia in this model . Regulation IL6 IL1B 7945622 276567 Neonatal tumor necrosis factor , interleukin-1 alpha , , and [interleukin-6] *response* to infection . Regulation IL6 IL1B 8041488 266689 We examined the production of interleukin (IL)-6 by human meningioma cells in vitro , and the *effects* of and IL-4 on [IL-6] production and meningioma cell growth . Regulation IL6 IL1B 8100098 220150 C8 cell line , which formed abundant osteoid or bone and was accompanied by no osteoclasts in the xenografted tumors , produced no detectable levels of IL-6 without stimulation , and the production of [IL-6] in *response* to was slower . Regulation IL6 IL1B 8190834 258664 Since hyporesponsiveness depends to a large extent on the stimulus , these experiments investigated the ontogeny of the HPA axis and [interleukin-6 (IL-6)] *responses* to . Regulation IL6 IL1B 8205350 261165 had a stimulatory *effect* on [IL-6] production by HAT . Regulation IL6 IL1B 8243265 236518 We conclude that 1 ) IL-1 receptors are involved in the ACTH and [IL-6] *responses* to rat ; Regulation IL6 IL1B 8275959 247191 Because IL-1 beta is known to induce IL-6 production in nonplacental mesenchymal cells and is locally produced by maternal decidua , this study was designed to determine whether could *regulate* [IL-6] production by second trimester placental villous core mesenchymal cells ( VCMC ) in vitro . Regulation IL6 IL1B 8774705 379640 The levels of both secreted [IL-6] and IL-6 mRNA are significantly higher in *response* to in spite of the fact that stimulation by TNF-alpha alone enhances the half life of IL-6 mRNA . Regulation IL6 IL1B 8964907 371711 differentially *affects* [interleukin-6] and soluble interleukin-6 receptor in the blood and central nervous system of the monkey . Regulation IL6 IL1B 9160463 431713 Normal and herniated human intervertebral disc specimens were cultured to study the *effects* of on the production of nitric oxide , [interleukin-6] , prostaglandin E2 , and matrix metalloproteinases . Regulation IL6 IL1B 9160463 431715 Normal , control disc specimens significantly increased their production of matrix metalloproteinases , nitric oxide , [interleukin-6] , and prostaglandin E2 in *response* to . Regulation IL6 IL1B 9160463 431717 Herniated lumbar and cervical discs , which were spontaneously releasing increased levels of these biochemical agents , further increased their production of nitric oxide , [interleukin-6] , and prostaglandin E2 in *response* to . Regulation IL6 IL1B 9277562 450799 These findings suggest that the plasma [IL-6] *response* to intravenous is partially mediated through the activation of the central noradrenergic system and a consequent increase in the sympathetic outflow to the peripheral tissues and that the NE released from the sympathetic terminals may function as a mediator and/or modulator to facilitate the synthesis/release of IL-6 in the sympathetic nerve innervated organs . Regulation IL6 IL1B 9326296 457102 These results demonstrate that expression of the genes encoding [IL-6] , IL-6R , and gp130 can be up-regulated in selective regions of the brain in *response* to the bacterial endotoxin LPS and the proinflammatory cytokine ( only for IL-6R expression ) . Regulation IL6 IL1B 9329125 457451 and interferon-gamma *regulate* [interleukin-6] production in cultured human intestinal epithelial cells . Regulation IL6 IL1B 9385777 466412 A dose dependent stimulatory *effect* of on [IL-6] production by HGF was noted , wherein 3 strains exhibited higher IL-6 activity than the other 3 . Regulation IL6 IL1B 9514921 492985 Furthermore , AM remarkably potentiated stimulatory *effects* of tumor necrosis factor-alpha , and lipopolysaccharide on [IL-6] production . Regulation IL6 IL1B 9516466 493153 Site-specific mutagenesis analysis demonstrated that the NF-kappaB and CBF1 binding elements regulated inducible activity of the [IL-6] promoter in *response* to stimulation , whereas the C/EBPbeta binding element mainly regulated basal activity . Regulation IL6 IL1B 9695734 524378 In addition , we examined the *effects* of TNF alpha and on mucosal [IL-6] production . Regulation IL6 IL1B 9695734 524383 Both TNF alpha and may be *involved* in the regulation of gastrointestinal [IL-6] production during endotoxemia . Regulation IL6 IL1B 9733787 531069 Here , we provide evidence that p38 MAP kinase is activated in *response* to in human FLSs and is involved in [IL-6] synthesis by stabilizing IL-6 mRNA . Regulation IL6 IL1R2 2969889 95652 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL6 IL6R 10633884 576676 *Role* of soluble in inflamed gingiva for binding of [interleukin-6] to gingival fibroblasts . Regulation IL6 IL6R 1321736 192045 We studied the *role* of in binding , internalization and down-regulation of the hepatic [IL6-receptor (IL6R)] by its ligand in human hepatoma cells ( HepG2 ) . Regulation IL6 IL6R 1321736 192046 Comparison of transfected HepG2 cells overexpressing gp80 with parental cells indicate that is *responsible* for low affinity binding ( Kd = 500 pM ) of [IL6] . Regulation IL6 IL6R 8878515 390664 *Effect* of soluble on [interleukin-6] synthesis in human skin fibroblasts . Regulation IL6 IL6R 9878116 557705 is *responsible* for [IL-6] binding , and its expression determines which cells respond to this cytokine . Regulation IL6 LBP 12193231 981027 Thereafter , the *effects* of LPS , soluble CD14 ( sCD14 ) and on the release of [interleukin-6 (IL-6)] and IL-8 were studied . Regulation IL6 LBP 16105094 1444830 The present in vitro study aimed to investigate the possible *effect* of and E. coli LPS interaction on the expression of cellular LPS receptors and [IL-6] by human gingival fibroblast . Regulation IL6 MAP2K6 14573621 1186484 In contrast , inhibitors of protein kinase A or C , , and phosphoinositide 3-kinase had no *effect* on [IL-6] mRNA levels . Regulation IL6 MAP2K6 15345332 1292166 These findings suggest that BK increased both [IL-6] and PGE ( 2 ) synthesis in osteoblastic cells via B2R and that PLC , IP ( 3 ) -induced [ Ca ( 2+ ) ] i , , and MAPKs were *involved* in the signal transduction in these cells . Regulation IL6 PECAM1 18025177 1827653 In this study , we demonstrate that ligation with CD38-Fc fusion protein negatively *regulates* LPS induced proinflammatory cytokine TNF-alpha , [IL-6] , and IFN-beta production by inhibiting JNK , NF-kappaB , and IFN regulatory factor 3 activation in macrophages . Regulation IL6 S100B 23755753 2797807 Soluble RAGE ( sRAGE ) reduced S100B dependent secretion of TNF-alpha but did not decrease *dependent* secretion of [IL-6] . Regulation IL6 SPHK1 17686057 1781490 Although sphingosine kinase (SPHK) signalling is known to play important roles in the regulation of cell proliferation and apoptosis , the *role* of activation in [IL-6] signalling and in the pathology of MM remains unclear . Regulation IL6 STAT4 19001140 1991090 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL6 STK39 8258686 238779 Taken together , our data demonstrate that activation of both a and a tyrosine kinase is *involved* in the IL-2 , IL-4 , and [IL-6-stimulation] of IgM secretion by SKW6.4 cells and activation of the same or a similar serine/threonine protein kinase is an early step in the signal transduction pathway used by these cytokines . Regulation IL6 TLR7 15588425 1345944 MEFs were highly responsive to TLR-ligand activation and secreted high levels of both [IL-6] and MCP-1 in *response* to ligands . Regulation IL6 TLR7 15994412 1447043 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for tumor necrosis factor ( TNF-alpha ) , [interleukin 6] , nitric oxide synthase-II ( iNOS ) , and NADPH oxidase 2 (Nox2) . Regulation IL6 TLR7 16368889 1539748 Intracellularly delivered isolated U1snRNA and oligoribonucleotides derived from the stem loop regions and the Sm-binding site of U1snRNA efficiently induced IFN-alpha and [IL-6] in Flt3L cultured DCs in a *dependent* manner . Regulation IL6 TLR7 17034424 1683372 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL6 TLR7 17521321 1767182 natural killer (NK)1.1 ( - ) CD11c ( + ) liver DC subsets ( conventional DCs , T cell receptor ( TcR ) beta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( - ) and plasmacytoid DCs , TcRbeta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( + ) ) efficiently endocytose dextran and produce significant levels of tumour necrosis factor (TNF)-alpha , [interleukin (IL)-6] and IL-12 p40 in *response* to ligands , with responses higher than splenic DCs . Regulation IL6 TLR7 17918201 1819440 In this study , we investigated which mouse B cell subsets are the most potent cytokine producers , and examined the *role* of in the control of secretion of [IL-6] , IL-10 , IL-12 and IFN-gamma by B cells . Regulation IL6 TLR7 18312842 1879766 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL6 TLR7 19322177 2064536 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of [interleukin (IL)-6] and IL-12p40 ( also known as IL12b ) , but not TNF , in *response* to ligands . Regulation IL6 TLR7 19890037 2165909 MAPKs are crucial for TNF-alpha and [IL-6] production by innate immune cells in *response* to ligands . Regulation IL6 TLR7 20471186 2294538 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL6 TLR7 20730378 2313323 Selective inhibitors of Kv11 .1 regulate [IL-6] expression by macrophages in *response* to ligands . Regulation IL6 TLR7 21039603 2382365 PDCs matured under Th1-like conditions showed a higher expression of antigens involved in T-cell co-stimulation and antigen presentation like CD40 , CD80 , CD83 and HLA-DR as well as a higher secretion of [IL-6] and IFN-a in *response* to compared to Th2-pDCs . Regulation IL6 TLR7 21881833 2599275 We now report that MM-derived MSCs manifested intact proliferation responses and [IL-6] secretion and their adipose and osteogenic differentiation *responses* to ligands were also similar to those of healthy controls , ranging from augmentation to inhibition . Regulation IL6 TLR7 22751696 2670332 To do so , we analyzed induced interleukin (IL)-1ß and [IL-6] *responses* in freshly isolated peripheral blood mononuclear cells ( PBMNCs ) from seropositive compared with seronegative subjects . Regulation IL6 TLR7 22904093 2683002 Nicotine and Ang II enhanced this mediated [IL-6] *response* in prehypertensive SHR splenocytes . Regulation IL6 TLR7 22904093 2683012 In contrast , nicotine suppressed the mediated [IL-6] *response* in WKY rats , whereas Ang II had no effect . Regulation IL6 TNF 10029203 591549 Females exhibited significantly higher corticosterone , , and [interleukin-6] *responses* than males . Regulation IL6 TNF 10037006 557545 However , the role of monoclonal antibodies , directed against these factors , confirmed the *role* of in the [IL-6] production by stromal cells , while any IL-1beta intervention was not shown in our co-culture system . Regulation IL6 TNF 10049519 557565 These results suggest that CINC produced in the pleural exudate may participate in neutrophil infiltration , that IL-6 induced in the plasma stimulates T-kininogen production , and that endogenous may be partly *involved* in the induction of CINC and [IL-6] in this zymosan inflammation . Regulation IL6 TNF 10319886 612050 To determine the extent to which the adenosine A1 receptor influenced cytokine expression in peripheral blood mononuclear cells ( PBMCs ) from MS and control patients , we measured plasma adenosine and levels , A1 receptor messenger RNA ( mRNA ) and protein amounts , and the *effects* of activation of A1 receptors on TNF alpha and [IL-6] production by PBMCs . Regulation IL6 TNF 10329846 613933 Enhanced [IL-6] production by high producing clones was *independent* of cytokines from other cell populations or autocrine production of and IL-1 . Regulation IL6 TNF 10358063 618739 IL-1beta and [IL-6] production were *independent* of production . Regulation IL6 TNF 10384135 624773 The extents of [IL-6] and IL-8 production in *response* to were greatly augmented by TRX as compared with TNF-alpha alone . Regulation IL6 TNF 10469353 641199 Using renal resident macrophage cells treated with endotoxin , lipopolysaccharide (LPS) , and beta2-adrenoceptor agonist , terbutaline , we investigated the *role* of cAMP pathway , and mitogen activated protein kinase (MAPK) pathway ( p42/p44 ) in regulating [IL-6] production . Regulation IL6 TNF 10504489 648991 In *response* to , the activation of both pathways leads to [IL-6] production . Regulation IL6 TNF 10569696 568027 We conclude that Th2-type cytokines IL-4 and IL-13 affect the release of [IL-6] by HBECs in *response* to ( inhibition ) and IFgamma ( augmentation ) . Regulation IL6 TNF 10632522 576579 We have also demonstrated that GF [IL-6] *responses* to bacterial challenge or are downregulated by CsA . Regulation IL6 TNF 10728932 579467 *Effects* of and IL-1 beta on mucin , lysozyme , [IL-6] and IL-8 in passage-2 normal human nasal epithelial cells . Regulation IL6 TNF 10795756 689767 CAPAN-1 cells had concentration dependent production of [IL-6] and IL-8 in *response* to both endotoxin and . Regulation IL6 TNF 10795756 689771 CAPAN-2 cells had concentration dependent production of [IL-6] and IL-8 in *response* to . Regulation IL6 TNF 10810212 692746 We studied the effects of pretreatment with either ibuprofen ( 15 mg/kg ) , diethylcarbamazine ( DEC , 15 mg/kg ) , or vehicle , on the hemodynamic , hematologic , and serum and [interleukin (IL)-6] *responses* to a bolus Escherichia coli endotoxin infusion ( 2 mg/kg ) in 21 pentobarbital anesthetized dogs ( n = 7 each group ) . Regulation IL6 TNF 10878380 708974 The acute-phase response ( APR ) is regulated by , IL-1beta , and [IL-6] *acting* alone , in combination , or in concert with hormones . Regulation IL6 TNF 10903137 712882 Analyses of secreted IL-6 by ELISA and of IL-6 mRNA by reverse transcription-PCR revealed that , whereas HeLa cells produced high levels of [IL-6] in *response* to and IL-1beta , the HTM-29 cell line failed to produce both IL-6 protein and mRNA . Regulation IL6 TNF 11007957 735667 NF-kappa B is the exclusive transcription factor for induction of the [IL-6] gene in *response* to and functions as the final trigger to activate a multiprotein complex , a so-called ` enhanceosome ' , at the level of the IL-6 promoter . Regulation IL6 TNF 11007957 735673 However , activation of NF-kappa B alone is not sufficient for [IL-6] gene induction in *response* to , as inhibition of the coactivated extracellular signal regulated kinase and p38 MAPK pathways blocks TNF mediated gene expression . Regulation IL6 TNF 11136824 769871 Production of [interleukin (IL)-6] in *response* to IL-1 alpha or was nearly abolished in homozygous mutant ( Shp-2 ( -/ ) - ) fibroblast cells . Regulation IL6 TNF 11165942 782830 The p38 mitogen activated protein kinase pathway regulates [interleukin-6] synthesis in *response* to in osteoblasts . Regulation IL6 TNF 11165942 782832 When added to MG-63 cells , had a stimulatory *effect* on the production of [IL-6] , and this elevation was significantly reduced by SB203580 , a specific p38 MAPK inhibitor . Regulation IL6 TNF 11237861 790421 We have recently demonstrated that nuclear factor kappaB (NF-kappaB) mediates the *dependent* expression of the gene encoding [interleukin 6 (IL-6)] in rat thyroid FRTL-5 cells cultured in the presence of thyrotropin ( TSH ) . Regulation IL6 TNF 11244034 792277 Clinical investigations in which the activity of TNF alpha in RA patients was blocked with intravenously administered infliximab , a chimeric anti-TNF alpha monoclonal antibody ( mAB ) , has provided evidence that *regulates* [IL-6] , IL-8 , MCP-1 , and VEGF production , recruitment of immune and inflammatory cells into joints , angiogenesis , and reduction of blood levels of matrix metalloproteinases-1 and -3 . Regulation IL6 TNF 11352809 814874 Stimulation with did not *affect* [IL-6] mRNA expression , whereas IL-1beta stimulated IL-6 mRNA and protein synthesis in a time- and concentration dependent fashion . Regulation IL6 TNF 11450697 836635 In contrast to these findings , the stimulatory *effects* of PTH , , and IL-1beta on the [IL-6] promoter expression were enhanced by staurosporine . Regulation IL6 TNF 11934972 927927 This suggests that *controls* [IL-6] production . Regulation IL6 TNF 11934972 927929 In addition , *regulates* [IL-6] production . Regulation IL6 TNF 11972797 934266 The aim of this study was to determine whether , in the absence of IL-1beta and [IL-6] , may *play* an equivalent pro-inflammatory role , or if an anti-inflammatory cytokine profile dominates . Regulation IL6 TNF 12016129 942167 in particular , the *effects* of IL-17 + on [IL-6] secretion were much stronger than the other responses . Regulation IL6 TNF 12017180 942401 To gain further insight into the molecular pathogenesis of pulpitis , we investigated the *effects* of IL-1alpha or and PGE2 , either alone or in combination on [IL-6] and cyclooxygenase (COX)-2 messenger RNA ( mRNA ) production in cultured human dental pulp ( HDP ) fibroblasts . Regulation IL6 TNF 12073205 956725 Blood samples for cytokine levels , , and [interleukin (IL)-6] *response* to CPB were collected after induction of anesthesia and at the end of CPB before protamine administration . Regulation IL6 TNF 12096891 961159 The present study tested whether prior exposure to inescapable tailshock ( IS ) alters the interleukin (IL)-1beta , , or [IL-6] *response* to an injection of bacterial endotoxin ( lipopolysaccharide ; Regulation IL6 TNF 12184911 978154 Transcription factor [NF-IL6] ( C/EBPbeta ) activates the expression of the mouse MHC class I H2-Kb gene in *response* to via the intragenic downstream regulatory element . Regulation IL6 TNF 12406900 1054814 In contrast , the response to zymosan or Staphylococcus aureus as well as the [interleukin-6 (IL-6)] and IL-8 *responses* to endotoxin were unaffected by ubiquitin . Regulation IL6 TNF 12524413 1047916 MMP2 secretion by PSCs was significantly increased by TGF-beta1 and [IL-6] , but was not *affected* by . Regulation IL6 TNF 12817006 1103567 Furthermore , activation of p38 mitogen activated protein kinase is shown to be essential for the inhibitory *effect* of on [IL-6] signaling and TNF-alpha dependent recruitment of SHP2 to gp130 . Regulation IL6 TNF 12875587 1115134 Addition of RXM at a concentration of 10.0 microg/ml to cell cultures suppressed both [IL-6] and RANTES ( but not IL-8 ) production in *response* to stimulation with 25.0 ng/ml . Regulation IL6 TNF 12928393 1132009 Decreased production of [IL-6] and KC in *response* to exogenous , in addition to protection from TNF-alpha , suggested that adenoviral infection results in TNF-alpha tolerance . Regulation IL6 TNF 1402392 199580 Tumor cell [IL-6] gene expression is *regulated* by IL-1 alpha/beta and : proposed feedback mechanisms induced by the interaction of tumor cells and macrophages . Regulation IL6 TNF 14534724 1152452 Tumor necrosis factor alpha (TNFalpha) and TNFalpha receptor mRNA expression , the *effects* of on DNA synthesis and cell proliferation as well as its effects on [interleukin-6 (IL-6)] production and expression in renal cell carcinoma (RCC) were studied using RCC cell lines . Regulation IL6 TNF 14534724 1152453 The *effects* of on DNA synthesis and [IL-6] production were also studied using short-term established RCC cell lines . Regulation IL6 TNF 14534724 1152455 When the *effects* of on [IL-6] production were studied by ELISA , IL-6 production was induced in RC-2 , RGB , 14T , OCUU-1 , OCUU-2 and OCUU-5 while not in 4T and OCUU-4 . Regulation IL6 TNF 14734475 1199282 However , in the resistant cells , the production of IL-1beta and [IL-6] were specifically impaired in *response* to . Regulation IL6 TNF 15003809 1217309 An endotoxicosis model that utilizes LPS and d-galactosamine to induce mortality by TNFalpha/TNFR1 dependent hepatocyte apoptosis was used to assess production , apoptotic signaling , and *effects* on the production of [IL-6] and IL-10 . Regulation IL6 TNF 1516257 196789 Peripheral blood mononuclear cells ( PBMC ) from untreated patients produced IL-1 beta , tumour necrosis factor-alpha (TNF-alpha) and [IL-6] in *response* to mitogenic stimulation with phytohaemagglutinin ( PHA ) , only low levels of IL-1 beta , IL-2 and in response to OvAg , but higher amounts of IL-4 and interferon-gamma (IFN-gamma) in response to OvAg than control individuals . Regulation IL6 TNF 15273081 1302470 Exaggerated IL-8 and [IL-6] *responses* to by parainfluenza virus type 4-infected NCI-H292 cells . Regulation IL6 TNF 15290727 1278563 In vitro , interferon-gamma (IFN-gamma) , and [interleukin 6 (IL-6)] *responses* were detected during reactions to most antigens tested , while IL-4 responses were absent . Regulation IL6 TNF 15325406 1287146 The second objective was to assess effects of human recombinant IL-10 on [interleukin-6 (IL-6)] and *responses* of human leukocytes to staphylococcal toxins implicated in SIDS . Regulation IL6 TNF 15474068 1318841 We determined the *effect* of on the production of [IL-6] and the effect of inhibitors for NF-kappaB and the MAPK pathway on IL-6 production using ELISA . Regulation IL6 TNF 15516323 1328536 We used RT-PCR to examine the *effects* of on bone sialoprotein ( BSP ) , core binding factor a1 (Cbfa1) , osterix , alpha 1 ( I ) collagen , cyclooxygenase-2 (COX-2) , [interleukin-6 (IL-6)] , cathepsin B , cathepsin L and tissue inhibitors of metalloproteinase-1 ( TIMP-1 ) . Regulation IL6 TNF 15611045 1375324 The ERK signaling pathway is not involved in and nitric oxide production , but , interestingly , negatively *regulates* the expression of [IL-6] and IL-12 . Regulation IL6 TNF 15818692 1393485 Nevertheless , the C43S TRAPS fibroblasts were capable of producing [interleukin-6 (IL-6)] and IL-8 in *response* to . Regulation IL6 TNF 1612734 191096 Pretreatment with corticosterone and RU 486 ( +Cort/+RU 486/+LPS ) significantly ( P less than 0.001 ) reversed the mortality observed with RU 486 pretreatment alone ( -Cort/+RU 486/+LPS ) , with 70 % of the animals surviving at 72 h , and significantly attenuated the peak plasma and [interleukin-6] *responses* to LPS , compared with those in the animals treated with vehicle alone . Regulation IL6 TNF 16403817 1540148 In contrast , inhibition of p38 MAPK only partially blocked the *effect* of on [IL-6] production . Regulation IL6 TNF 16407046 1513312 We investigated whether HDSMCs are capable of expressing and releasing MCP-1 , [IL-6] and SCF in *response* to IL-4 , IL-13 , IL-1beta and . Regulation IL6 TNF 1667942 176669 In this paper , we examined the *effects* of on [IL-6] production by human synovial fibroblasts . Regulation IL6 TNF 16859503 1663416 Adhered monocytes , after 3-day preincubation with IL-10 and M-CSF , could produce more IL-1beta and [IL-6] in *response* to in the presence of dibutyryl cAMP , as compared with the cells preincubated with or without IL-10 or M-CSF alone . Regulation IL6 TNF 16869254 1593034 Oxygen dependent killing was *controlled* mostly by [IL-6] during the pre-operative period , and by this plus 24 hours after surgery . Regulation IL6 TNF 1705566 152967 The *effect* does not occur at 0 degrees C and can not be induced by IL-2 , [IL-6] , or GM-CSF . Regulation IL6 TNF 17223661 1765551 In contrast , inhibition of p38 reversed *effects* on proliferation and [IL6/PGE] ( 2 ) secretion ( but not on IL8 and MMP-3 secretion ) . Regulation IL6 TNF 1727819 180939 Collectively , trophoblast derived and IL-1 synergistically *regulated* the level of [IL-6] secreted by trophoblasts , the magnitude of which determined the level of hCG released by activating the IL-6-R system in trophoblasts . Regulation IL6 TNF 18236210 1839464 Mechanism of crosstalk inhibition of [IL-6] signaling in *response* to LPS and . Regulation IL6 TNF 18291623 1878551 The plaa ( high ) cells produced significantly more PGE ( 2 ) and [interleukin (IL)-6] compared to plaa ( low ) cells in *response* to . Regulation IL6 TNF 18502965 1917760 [IL-6-type] cytokine expression and *regulation* by IL-1beta and were studied in fibroblasts from the non inflamed gingiva of healthy individuals . Regulation IL6 TNF 18565117 1959179 In contrast , PP DC produced [IL-6] only in *response* to E. coli , little IL-10 and no , and this low cytokine production was not due to inhibition by IL-10 or TGF-beta . Regulation IL6 TNF 18684450 2059329 We examined the *effects* of and IL-10 on the expression of [IL-6] or IL-8 by real-time RT-PCR and ELISA . Regulation IL6 TNF 1918983 168458 Taken together , results reported here provide evidence that functional interaction between IFN-gamma and is *involved* in the regulation of IL-6 and [IL-6R] expression in monocytic cells . Regulation IL6 TNF 19380468 2094699 Cellular , gamma interferon , and [interleukin-6] *responses* as correlates of immunity and risk of clinical Plasmodium falciparum malaria in children from Papua New Guinea . Regulation IL6 TNF 19580863 2142577 In this study we investigated the *role* of IL-1 beta , and COX2 in silica induced regulation of [IL-6] release and pneumocyte loss in various mono- and co-cultures of monocytes , pneumocytes and endothelial cells . Regulation IL6 TNF 19583958 2162567 SB202190 successfully suppressed [IL-6] , IL-8 , PGE2 , and PGF2alpha secretion in macrophage exposed AF cells in *response* to . Regulation IL6 TNF 19666104 2182973 Conversely , following TLR 9 stimulation there was a decrease in IL-1beta , [IL-6] , GM-CSF , and *responses* in monocyte cell cultures from children with ASD compared with controls ( p < 0.05 ) . Regulation IL6 TNF 19697035 2258170 The level of [IL-6] expression was strongly increased in both FLSs and THP-1 macrophages in *response* to IL-1beta and , but the level by TNF-alpha was less than that by IL-1beta . Regulation IL6 TNF 20029520 2175603 This aims of this study were to investigate the effects of carbohydrate availability during endurance training on the plasma [interleukin (IL)-6] , IL-8 , and *response* to a subsequent acute bout of high-intensity interval exercise . Regulation IL6 TNF 2026875 157480 In addition , it was shown that IL-6 production by in vitro activated B cells was partially blocked by an anti-TNF-alpha antibody suggesting that *regulates* [IL-6] production in normal B cells via an autocrine pathway . Regulation IL6 TNF 20406675 2267519 The *effects* of on IL-8 and [IL-6] or NO production were stronger upon combination with IL-1beta or IFN-gamma , respectively , whereas cells were unaffected by the presence of LPS . Regulation IL6 TNF 21191629 2425304 We examined the *effects* of on expression and release of [interleukin-6 (IL-6)] by human urothelial cells ( HUCs ) and investigated whether the effects of TNF-a are mediated by mitogen activated protein kinase (MAPK) pathways . Regulation IL6 TNF 21492875 2438892 Enzyme linked immunoassay ( ELISA ) was used to evaluate [interleukin-6 (IL-6)] expression in *response* to IL-1ß and stimulation in vitro to validate MK2 kinase inhibition . Regulation IL6 TNF 21995333 2507620 Moreover induction of [IL-6] and IL-8 was primarily *regulated* by MC-derived . Regulation IL6 TNF 22190977 2531316 Blockage of Notch signaling by a ?-secretase inhibitor ( DAPT ) inhibited [IL-6] secretion of RA FLSs in *response* to while treatment with recombinant fusion protein of Notch ligand Delta-like 1 promoted such response . Regulation IL6 TNF 22226857 2559202 Knockdown of ASMase attenuated the enhancement of *dependent* [IL-6] production . Regulation IL6 TNF 2226778 144477 Differential *regulation* of [interleukin-6] expression in human fibroblasts by and lymphotoxin . Regulation IL6 TNF 22422499 2588060 We evaluated the *effect* of interferon-? ( IFN-? ) and/or on the secretion of prototype proinflammatory cytokine [interleukin 6 (IL-6)] , compared to T-helper 1 [ Th1 ; chemokine (C-X-C motif) ligand 10 ( CXCL10 ) ] or Th2 [ chemokine (C-C motif) ligand 2 ( CCL2 ) ] chemokines , in primary cultured fibroblasts from patients with systemic sclerosis ( SSc ) at an early stage of the disease . Regulation IL6 TNF 2265482 147237 Several studies have shown that the cytokine [interleukin-6 (IL-6)] is produced in *response* to in vitro . Regulation IL6 TNF 22693231 2638700 Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß) , [interleukin 6 (IL-6)] , interleukin 10 (IL-10) , interleukin 12 (IL-12) , and *responses* to Toll-like receptor (TLR) 3 and TLR4 stimulation . Regulation IL6 TNF 22714139 2670059 Childhood abuse history moderated [IL-6] levels but not and CRP *responses* to daily stressors . Regulation IL6 TNF 23159491 2729680 Finally , we demonstrate that the transmembrane forms of wild-type and palmitoylation-defective interact differently with TNFR1 and *regulate* NF?B activity , Erk1/2 phosphorylation and [interleukin-6] synthesis differently , strongly suggesting that palmitoylation of TNF is involved in the regulation of TNFR1 signalling . Regulation IL6 TNF 23261764 2737328 These data suggested that the increased IL-6 in afferent neurons and spinal cord contribute to the development of neuropathic pain following motor fiber injury , and that is *responsible* for the up-regulation of [IL-6] . Regulation IL6 TNF 23445729 2749243 We also found that high-dose IgG specifically and completely inhibited accelerated expression of KD-related cytokines such as G-CSF , [IL-6] and IL-1ß by HCAEC in *response* to . Regulation IL6 TNF 23835341 2865820 Direct *effects* of on local fuel metabolism and cytokine levels in the placebo controlled , bilaterally infused human leg : increased insulin sensitivity , increased net protein breakdown , and increased [IL-6] release . Regulation IL6 TNF 24062615 2846674 We have demonstrated that budesonide concentration-dependently ( 10 ( -10 ) -10 ( -7 ) M ) inhibited [IL-6] , IL-8 , MMP-1 , and MMP-3 release by HFL-1 cells in *response* to IL-1ß plus . Regulation IL6 TNF 24129565 2875073 Chromatin immunoprecipitation ( ChIP ) assays demonstrated decreased NF-?B binding to the promoters of [IL-6] , IL-8 , and I?Ba in *response* to with TGF-ß1 pretreatment . Regulation IL6 TNF 24138989 2882717 Furthermore , from the optimized IRN , we confirmed 45 interactions between proteins in biological experiments and identified 37 new regulatory interactions and 8 false positive interactions , including the following interactions : IL1ß regulates TLR3 , TLR3 regulates IFN-ß and *regulates* [IL6] . Regulation IL6 TNF 2483767 103992 One set of acute phase proteins , including alpha 2-macroglobulin , alpha 1-antichymotrypsin ( = contrapsin ) , cysteine protease inhibitor ( = thiostatin ) , alpha 1-antitrypsin , ceruloplasmin and fibrinogens are predominantly *regulated* by the keratinocyte derived HSF-III/-II or [IL-6] , while a second set of proteins , including alpha 1-acid glycoprotein ( AGP ) , haptoglobin and complement C3 are predominantly regulated by keratinocyte derived HSF-I , IL-1 or . Regulation IL6 TNF 2501390 113946 The magnitude for the *effects* of IFN-gamma and on the production of [IL-6] from mouse islets was found to be both time and dose dependent . Regulation IL6 TNF 2523936 109930 In contrast to the similarities between the *effects* of IL-1 and on synthesis of factor B , C3 , and IFN-beta [2/IL-6] , only TNF increased synthesis of factor H . Regulation IL6 TNF 2547871 115658 *Effects* of and epidermal growth factor on cell morphology , cell surface receptors , and the production of tissue inhibitor of metalloproteinases and [IL-6] in human microvascular endothelial cells . Regulation IL6 TNF 2805453 121249 The coinjection of antiserum against rMuTNF-alpha with LPS resulted in a reduction of the induced serum IL-6 level , indicating the *involvement* of endogenous in LPS induction of [IL-6] . Regulation IL6 TNF 3486658 59991 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL6 TNF 3491252 65996 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL6 TNF 7492273 335540 To test the hypothesis that pretreatment with liposomes enriched with the omega 3 fatty acid docosahexaenoic acid ( 22 : 6 omega 3 ) will alter the Kupffer 's cell and systemic cytokine ( and [interleukin-6] ) *response* to endotoxin challenge , and to demonstrate alterations in Kupffer 's cell phospholipid fatty acid composition after in vivo liposome treatment . Regulation IL6 TNF 7506738 244461 However , inhibition of the cAMP pathway effector , protein kinase A , did not reduce the induction of astrocyte [IL-6] gene expression in *response* to IL-1 beta or , and an ELISA for cAMP detected only very small increases in cAMP synthesis in response to these cytokines . Regulation IL6 TNF 7743669 306079 LPS , IFN-gamma or had no *effect* on spontaneous [IL-6] production , and neither resulted in the secretion of IL-1 beta or TNF-alpha . Regulation IL6 TNF 7890313 289749 In the present study we investigated the *effects* of and interferon-gamma (IFN-gamma) on the secretion of [interleukin-6 (IL-6)] by myoblasts . Regulation IL6 TNF 7927780 273969 In this model , is also partially *responsible* for the induction of [interleukin-6 (IL-6)] . Regulation IL6 TNF 7934096 275457 A local production of these cytokines can not be excluded , because [interleukin-6] and interleukin-8 are produced by stimulated macrophages and monocytes in *response* to and interleukin-1 beta . Regulation IL6 TNF 7967599 279759 We conclude that although *plays* an important role in synthesis and release of [IL-6] , there is a TNF-alpha independent pathway for release of IL-6 in sepsis . Regulation IL6 TNF 7978630 281269 In contrast , compared with effects of endotoxin given without pretreatment , use of antiserum was associated with significantly ( P < 0.05 ) higher respiratory rate , maximal plasma [IL-6] activity , and total *response* ( as determined by areas under curves of plasma TNF vs time ) . Regulation IL6 TNF 7986155 282364 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL6 TNF 8199531 259489 Prompted by this evidence , we have now examined whether and/or IL-1 are produced by murine calvarial cells , and whether these cytokines are *involved* in [IL-6] production and osteoclast formation . Regulation IL6 TNF 8284058 240642 Serum endotoxin , , and [interleukin-6] *response* to total hip arthroplasty . Regulation IL6 TNF 8579900 326540 Even though these observations establish that IL-6 is an essential pathogenetic factor in the bone loss caused by gonadal deficiency , it remains unclear whether [IL-6] is the sole pathogenetic factor or whether IL-1 , , and IL-11 may also be *involved* . Regulation IL6 TNF 8627304 355869 Whereas activation of protein kinase A was able to induce expression of the IL-6 gene , it did not induce gene expression and was not *involved* in IL-1 beta induced [IL-6] and TNF alpha gene expression . Regulation IL6 TNF 8739203 343437 Similarly , IL-1 and *affect* granulosa cell steroidogenesis and [IL-6] production . Regulation IL6 TNF 8928945 338223 The induction of IL-1 , IL-1 inhibitory activity [IL-6] , WBC , and total protein concentration responses are largely *independent* of activity in synovial fluid of horses receiving endotoxin intra-articularly . Regulation IL6 TNF 9087647 421679 The data indicate that IL-1 and *act* locally at the site of inflammation and that locally induced [IL-6] is the important systemic mediator of the response . Regulation IL6 TNF 9154298 431353 The increase in IL-6 luciferase activity occurs in the absence of the multiple response region , the area of the [IL-6] promoter *responsive* to IL-1 , , cyclic amp , and phorbol 12-myristate 13-acetate . Regulation IL6 TNF 9160997 431827 Taken together , these results suggest that the endogenously hypersecreted is indirectly *responsible* for the previously reported elevated IL-1- , [IL-6-] , and IL-10 secreting capabilities of frozen PBMCs . Regulation IL6 TNF 9228922 443637 The current study was designed to determine the potential *effects* of blockade , by means of monoclonal antibody ( TNF MoAb ) treatment , on plasma [interleukin 6 (IL-6)] in rats after acute intestinal I/R injury . Regulation IL6 TNF 9502421 491221 Neither anti-human nor IL-1 antibody *affected* spontaneous [IL-6] production of these FLS clones , suggesting that IL-6 production of the FLSs was endogenously up-regulated . Regulation IL6 TNF 9528954 496211 The present study examined the *effects* of on the activation of nuclear factor-kappa B (NF-kappaB) and on the expression of [interleukin (IL)-6] gene in rat thyroid FRTL-5 cells . Regulation IL6 TNF 9528954 496224 These results strongly suggest that TNF-alpha increases the IL-6 gene expression through the activation of NF-kappaB in the thyroid cells , and that antioxidants suppress the *dependent* [IL-6] expression by inhibiting the activation of the transcriptionally active NF-kappaB . Regulation IL6 TNF 9555981 499247 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the interferon (IFN)-alpha , IFN-beta , [interleukin-6 (IL-6)] , and *response* to NDV but not to Sendai virus . Regulation IL6 TNF 9695734 524377 In addition , we examined the *effects* of and IL-1 beta on mucosal [IL-6] production . Regulation IL6 TNF 9695734 524382 Both and IL-1 beta may be *involved* in the regulation of gastrointestinal [IL-6] production during endotoxemia . Regulation IL6 TNF 9718198 528198 An antioxidant , N-acetyl-L-cysteine , significantly attenuated the TNF-alpha dependent increase in these mRNAs , and simultaneously reduced the activation of NF-kappaB by TNF-alpha , indicating that NF-kappaB mediates the *dependent* expression of [IL-6] and ICAM-1 in ROS17/2.8 cells . Regulation IL6 TNF 9728802 530070 The synthesis of IL-6 was significantly enhanced by TNF-alpha in BMMC and ALL-T while the presence of had no *effect* on [IL-6] synthesis in the culture of cALL leukemic cells . Regulation IL6 TNF 9806041 544717 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL6 TP63 15126418 1244847 These findings suggest that would *regulate* the cell adhesive property through ICAM-1/LFA-1 interaction and the production of [IL-6] and IL-8 , probably in all TEC subtypes . Regulation IL6R CA2 8713082 373593 While depletion of from the endoplasmic reticulum had no *effect* on the degradation of [Inv-gp80sc] , it stimulated the degradation of Inv-gp80 . Regulation IL6R IFNA1 7619053 315535 The *effects* of on the [interleukin-6 (IL-6) receptor] in a multiple myeloma cell line , U266 , have been examined . Regulation IL6R IFNA10 7619053 315536 The *effects* of on the [interleukin-6 (IL-6) receptor] in a multiple myeloma cell line , U266 , have been examined . Regulation IL6R IFNA13 7619053 315537 The *effects* of on the [interleukin-6 (IL-6) receptor] in a multiple myeloma cell line , U266 , have been examined . Regulation IL6R IFNA14 7619053 315538 The *effects* of on the [interleukin-6 (IL-6) receptor] in a multiple myeloma cell line , U266 , have been examined . Regulation IL6R IFNA16 7619053 315539 The *effects* of on the [interleukin-6 (IL-6) receptor] in a multiple myeloma cell line , U266 , have been examined . Regulation IL6R IFNA17 7619053 315540 The *effects* of on the [interleukin-6 (IL-6) receptor] in a multiple myeloma cell line , U266 , have been examined . Regulation IL6R IFNA2 7619053 315541 The *effects* of on the [interleukin-6 (IL-6) receptor] in a multiple myeloma cell line , U266 , have been examined . Regulation IL6R IFNA21 7619053 315542 The *effects* of on the [interleukin-6 (IL-6) receptor] in a multiple myeloma cell line , U266 , have been examined . Regulation IL6R IFNA4 7619053 315543 The *effects* of on the [interleukin-6 (IL-6) receptor] in a multiple myeloma cell line , U266 , have been examined . Regulation IL6R IFNA5 7619053 315544 The *effects* of on the [interleukin-6 (IL-6) receptor] in a multiple myeloma cell line , U266 , have been examined . Regulation IL6R IFNA6 7619053 315545 The *effects* of on the [interleukin-6 (IL-6) receptor] in a multiple myeloma cell line , U266 , have been examined . Regulation IL6R IFNA7 7619053 315546 The *effects* of on the [interleukin-6 (IL-6) receptor] in a multiple myeloma cell line , U266 , have been examined . Regulation IL6R IFNA8 7619053 315547 The *effects* of on the [interleukin-6 (IL-6) receptor] in a multiple myeloma cell line , U266 , have been examined . Regulation IL6R IL1B 8964907 371712 differentially *affects* interleukin-6 and soluble [interleukin-6 receptor] in the blood and central nervous system of the monkey . Regulation IL6R IL6 14637393 1171517 How does *affect* the membrane expressions of [interleukin-6 receptor] and gp130 and the proliferation of the human myeloma cell line OPM-2 ? Regulation IL6R IL6 8200278 242895 The *effect* of the recombinant on both the LT12-IL6R+ cells and the IL6R- parental cells ( [LT12-IL6R-] ) was studied by leukemic progenitor colony ( CFU-L ) formation and 3H-TdR incorporation assays . Regulation IL6R IL6 9714910 527749 Expression of [interleukin-6 (IL-6) receptor] gene in acute myeloblastic leukemia and *response* of leukemic cells to exogenous . Regulation IL6R MYLIP 24642471 2930499 p53 activation in CRC cells interfered with IL-6 induced invasion and migration via *dependent* downregulation of [IL6R] expression . Regulation IL6R STAT3 11562527 862865 Soluble [interleukin-6 receptor] activates the human papillomavirus type 18 long control region in SW756 cervical carcinoma cells in a *dependent* manner . Regulation IL6ST TNF 9528954 496219 The treatment with the antioxidants 20 mM N-acetyl-L-cysteine (NAC) and 10 microM pyrrolidine dithiocarbamate ( PDTC ) inhibited the *dependent* activation of p65-p50 [heterodimer] but not the p50-p50 homodimer , indicating that generation of oxidants is required for the activation of the heterodimer NF-kappaB . Regulation IL6ST TP63 9614940 509537 In order to elucidate the *role* of in the [heterodimer] , chimeric HIV-1/FIV RT heterodimers were constructed and characterized . Regulation IL7 ALOX5 8722494 373704 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL7 IL1B 14617515 1200675 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL7 IL1B 20497296 2289067 The *role* of in reduced [IL-7] production by stromal and epithelial cells : a model for impaired T-cell numbers in the gut during HIV-1 infection . Regulation IL7 IL1R2 2969889 95654 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL7 STAT4 19001140 1991091 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL7 TLR7 17034424 1683382 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL7 TLR7 18312842 1879776 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL7 TLR7 19285437 2051542 Thus , T cell responses are regulated by hepatocyte derived [IL-7] , which is expressed in *response* to signaling in vivo . Regulation IL7 TLR7 20471186 2294548 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL7 TNF 17185327 1724572 In addition , the *effect* of blockade on IL7 activity and on [IL7] levels was studied . Regulation IL7 TNF 3486658 59992 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL7 TNF 3491252 65997 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL7 TNF 7986155 282365 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL7 TNF 9806041 544720 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL7R FOXO1 19136962 2025522 Finally , growth factor withdrawal induced a *dependent* increase in Sell , Klf2 and [Il7r] expression . Regulation IL7R MAML3 19349467 2057582 dependent Notch1 signaling *controls* T lineage-specific [IL-7R{alpha] } gene expression in early human thymopoiesis and leukemia . Regulation IL7R TNF 10779425 687449 The *effect* resulted in an up-regulation of [CD127] ( ie , the IL-7 receptor alpha-chain ) in a small subset of the CD34+ cells . Regulation IL8 ALOX5 8722494 373705 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL8 CAPN8 15985533 1428651 We observed a smoke extract induced , *dependent* degradation of the intracellular form of platelet-endothelial cell adhesion molecule 1/CD31 , as well as a release of P-selectin/CD62P , IL-6 , and [IL-8] from endothelial cells into the supernatant . Regulation IL8 CD14 12193231 981028 Thereafter , the *effects* of LPS , soluble ( sCD14 ) and LPS binding protein (LBP) on the release of interleukin-6 (IL-6) and [IL-8] were studied . Regulation IL8 CD14 7681082 214208 *Involvement* of in lipopolysaccharide induced tumor necrosis factor-alpha , IL-6 and [IL-8] release by human monocytes and alveolar macrophages . Regulation IL8 CD14 7681082 214214 We conclude that is *involved* in LPS induced release of TNF-alpha , IL-6 , and [IL-8] by monocytes and alveolar macrophages and that this receptor appears to be able to recognize LPS directly in the absence of serum . Regulation IL8 CTGF 16204411 1517629 The direct *effect* of ( 20 , 200 , and 400 ng/ml ) on [IL-8] and MCP-1 was assessed at 24- , 48- , and 72-h time points and no stimulation was observed . Regulation IL8 EPHB2 12388360 1035042 Finally , although ERK activation was required for maximal asialoGM1 mediated IL-8 expression , inhibition of ERK signaling had no effect on IKK or NF-kappaB activation , suggesting that *regulates* [IL-8] expression in an NF-kappaB independent manner . Regulation IL8 EPHB2 16373669 1539793 Zn2+ induced [IL-8] expression *involves* AP-1 , JNK , and activities in human airway epithelial cells . Regulation IL8 EPHB2 16530725 1536437 Inhibitors of either extracellular signal regulating kinase ( ERK ) or phosphatidylinositol 3-kinase (PI3K) partly reversed the thrombin induced cytokine expression , suggesting that both and PI3K kinase pathways may be *involved* in [IL-8] and VEGF expression . Regulation IL8 EPHB2 17893134 1823893 C. trachomatis serovar D also induced [IL-8] in an *dependent* manner . Regulation IL8 EPHB2 20307528 2244595 Using the inhibitors of the MAP kinases and NFkappaB , it was revealed that p38 , JNK and , as well as NFkappaB , are all *involved* in LPS induced [IL-8] secretion ; Regulation IL8 EPHB2 20460732 2262918 However , PD98059 ( a MEK1/2 inhibitor ) dramatically down-regulated this cytokine , suggesting *dependent* [IL-8] production . Regulation IL8 EPHB2 20591071 2285897 Through ERK inhibitor ( U0126 ) and NF-kB inhibitor ( caffeine acid phenethyl ester ) treatment , it was proven that and NF-kB *regulated* chitinase induced [IL-8] expression . Regulation IL8 EPHB2 24647471 2925842 Additionally , we reveal that S1P induced [IL-8] secretion is p38 MAPK and *dependent* and that these key phosphoproteins act on the downstream effector mitogen- and stress activated kinase 1 ( MSK1 ) to control secretion of the neutrophil chemoattractant cytokine IL-8 . Regulation IL8 F2R 12506061 1038290 HCE-T expression of cytokines ( IL-6 , [IL-8] , and TNFalpha ) in *response* to activation of and -2 was measured by quantitative RT-PCR and ELISA . Regulation IL8 F2R 19308689 2007676 Notably , in many tumor types including melanoma , expression directly correlates with their metastatic phenotype and is directly *responsible* for the expression of [interleukin-8] , matrix metalloproteinase-2 (MMP-2) , vascular endothelial growth factor , platelet derived growth factor , and integrins . Regulation IL8 F3 21472232 2361563 VIIa *regulates* [interleukin-8] , tissue factor and caspase-7 expression in SW620 cells through protease activated receptor-2 activation . Regulation IL8 FAS 15831231 1394445 In addition to hypoxia/anoxia stimulation , increased [IL-8] in gliomas occurs in *response* to ligation , death receptor activation , cytosolic Ca ( 2+ ) , TNF-alpha , IL-1 , and other cytokines and various cellular stresses . Regulation IL8 FAS 7594569 325867 This study shows that the pathways leading to cell death and [IL-8] production in *response* to Ag ligation and TNF-alpha were similar with regard to their requirements for new gene expression , protein synthesis , and protein kinase activity . Regulation IL8 FUT4 10440571 635336 We investigated the *effect* of , a serine protease inhibitor , on the production of pro-inflammatory cytokines , interleukin-6 (IL-6) and [interleukin-8 (IL-8)] , by monocytes stimulated with lipopolysaccharide (LPS) . Regulation IL8 FUT4 7620820 315581 We investigated the inhibitory *effects* of a protease inhibitor , , on the production of [interleukin 8 (IL-8)] and polymorphonuclear leukocyte elastase ( PMNE ) by polymorphonuclear leukocytes ( PMN ) and vascular endothelial cells . Regulation IL8 HBEGF 22402363 2582155 The silencing and overexpression of HBEGF in HAECs confirmed the *role* of in regulating [IL-8] expression . Regulation IL8 IL1B 10641976 660755 Induction of [interleukin-8] release by lung epithelium with cystic fibrosis epithelial lining fluid is marginally *affected* by inhibitors of . Regulation IL8 IL1B 10728932 579470 *Effects* of TNF-alpha and on mucin , lysozyme , IL-6 and [IL-8] in passage-2 normal human nasal epithelial cells . Regulation IL8 IL1B 11191284 761402 *Effect* of IFNgamma , TNFalpha and on viability , butyrate oxidation and [IL-8] secretion . Regulation IL8 IL1B 11358991 816225 The NO synthase inhibitors aminoguanidine and N ( G ) -nitro-L-arginine methyl ester blocked nuclear accumulation of activator protein-1 (AP-1) and nuclear factor (NF)-kappaB in both polymorphonuclear ( PMN ) and mononuclear leukocytes and inhibited [IL-8] mRNA expression and IL-8 release by approximately 90 % in *response* to and TNF-alpha . Regulation IL8 IL1B 11377390 820214 The additive *effect* of H. pylori and on [IL-8] production was inhibited by treatment with a p38 MAPK inhibitor . Regulation IL8 IL1B 11446462 835396 Regulatory *role* of in the expression of IL-6 and [IL-8] in human corneal epithelial cells during Pseudomonas aeruginosa colonization . Regulation IL8 IL1B 11767276 890362 We aimed to : 1 ) characterize the expression of interleukin (IL)- Ialpha and IL-Ibeta in human gingiva and cultured GEC : 2 ) demonstrate the ability of A. actinomycetemcomitans extracts to upregulate IL-1alpha , IL-1beta and IL-8 expression in GEC in vitro : and 3 ) characterize the *role* of IL-1alpha and in the induction of [IL-8] expression in GEC in vitro . Regulation IL8 IL1B 11910356 924165 Toxin A did not increase IL-8 levels in EB-treated cells , whereas [IL-8] release in *response* to was not affected . Regulation IL8 IL1B 12045890 895172 The *role* of in the regulation of [IL-8] and IL-6 in human corneal epithelial cells during Pseudomonas aeruginosa colonization . Regulation IL8 IL1B 12045890 895176 The purpose of this study was to investigate whether *regulates* the expression of IL-6 and [IL-8] in human corneal epithelial cells during Pseudomonas aeruginosa colonization . Regulation IL8 IL1B 12507912 1038462 Compared to non-CF cells , CF bronchial epithelial cells were characterized by a higher susceptibility to produce elevated [IL-8] and RANTES production in an hypertonic NaCl milieu in *response* to activation . Regulation IL8 IL1B 12672669 1099639 In this study , we examined the *effects* of and progesterone on IL-8 and prostaglandin E2 ( PGE2 ) synthesis and [IL-8] and COX-2 mRNA and promoter activity in amnion cells and lower segment fibroblast ( LSF ) cells . Regulation IL8 IL1B 14617515 1200676 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL8 IL1B 15208668 1281323 In this study , the *effect* of on [IL-8] expression in human gastric cancer TMK-1 cells and the underlying signal transduction pathways were investigated . Regulation IL8 IL1B 15349048 1292337 Conjunctival epithelial cells release [interleukin-8] in *response* to and tumor necrosis factor alpha but not interferon-gamma . Regulation IL8 IL1B 15373918 1297891 Levels of IL-8 and , a *regulator* of [IL-8] expression , were determined by enzyme linked immunosorbent assay ( ELISA ) . Regulation IL8 IL1B 15591589 1356332 Concomitant with accelerated maturation , the [IL-8] *response* to both and LPS was significantly dampened ( from 6- to 3-fold ) by glucocorticoid pretreatment in the immature but not mature xenografts . Regulation IL8 IL1B 15664665 1365288 Similar to BK , the calcium ionophore A23187 also upregulated the stimulatory *effect* of and TNFalpha on [IL-8] production . Regulation IL8 IL1B 16202385 1468522 It has been reported that the differentiation of colonic epithelial cells is associated with reduced [interleukin (IL)-8] *responses* to . Regulation IL8 IL1B 16322091 1533064 The anti-inflammatory effect extends to both bacterial and host derived proinflammatory stimuli , since prior infection with EPEC suppressed the [IL-8] *response* to tumor necrosis factor-alpha , , and enterohemorrhagic E. coli flagellin . Regulation IL8 IL1B 16354411 1492520 Licochalcone A ( IC50 15.0 nM ) inhibited PGE2 production , but not IL-6 and [IL-8] production , in *response* to . Regulation IL8 IL1B 16448811 1589160 However , pyocyanin upregulated the stimulatory *effect* of or PDBu on the release of [IL-8] in a dose dependent manner . Regulation IL8 IL1B 16616208 1582984 In the present study , we examined the *effect* of on the expression of IL-1beta , IL-6 , [IL-8] , IL-11 , tumor necrosis factor-alpha (TNF-alpha) , and their receptors in human chondrocytes . Regulation IL8 IL1B 17086498 1496984 Combined *effect* of 25-hydroxycholesterol and on [IL-8] production in human colon carcinoma cell line ( Caco-2 ) . Regulation IL8 IL1B 17693924 1882330 Lastly , inhibition of exportin 1 attenuates monocyte chemoattractant protein , [IL-8] , and intercellular adhesion molecule expression in *response* to stimulation . Regulation IL8 IL1B 18308354 1885937 We found that deoxynivalenol , ochratoxin A and patulin all potentiated the *effect* of on [IL-8] secretion ( ranging from 35 % to 138 % increase ) and increased the transepithelial passage of commensal bacteria ( ranging from 12- to 1544-fold increase ) . Regulation IL8 IL1B 18978040 2015152 CF and non-CF cell lines produced similar levels of IL-8 at baseline and equally increased [IL-8] secretion in *response* to , TNF-alpha , and the Toll-like receptor 2 agonist Pam3Cys . Regulation IL8 IL1B 19626664 2137608 however , it is not clear whether *regulates* [IL-8] expression in prostate cancer cells . Regulation IL8 IL1B 19626664 2137610 Three prostate cancer cell lines , DU-145 , PC-3 , and LNCaP , were used to evaluate the *effects* of and glucosamine on [IL-8] expression using ELISA and RT-PCR analyses . Regulation IL8 IL1B 19887769 2197294 The present data do not support the hypothesis that ibuprofen down-regulates [IL-8] production in *response* to TNF-alpha and in CF respiratory epithelium . Regulation IL8 IL1B 20194723 2229337 Taken together , our results suggest that BLT2-Nox1-reactive oxygen species dependent pathway plays a role in promoting the secretion of [IL-8] from human mast cells in *response* to the proinflammatory cytokine , thus contributing to angiogenesis . Regulation IL8 IL1B 20525168 2284209 Functional studies indicated that induced miR-146a expression does not negatively *regulate* IL-6 and [IL-8] release or basal proliferation . Regulation IL8 IL1B 22685373 2611666 In this study we investigated the roles of these transcription factors in *regulation* of the [IL8] gene in human myometrium . Regulation IL8 IL1B 22685373 2611667 Small interfering RNA ( siRNA ) silencing of NF?B abolished the [IL8] *response* to significantly ; Regulation IL8 IL1B 8112434 241835 Local production of [IL-8] in *response* to elastase and , together with the inactivation of the anti-inflammatory protein IL-6 , may result in a significant upregulation of airway inflammation in cystic fibrosis . Regulation IL8 IL1B 8216423 231661 Synergistic *effect* of and tumor necrosis factor alpha on [interleukin-8] gene expression in synovial fibroblasts . Regulation IL8 IL1B 8663179 368392 *Regulation* of [interleukin-8] gene expression by , osteotropic hormones , and protein kinase inhibitors in normal human bone marrow stromal cells . Regulation IL8 IL1B 8663179 368397 Furthermore , as determined by nuclear run-on analysis , increased the rate of transcription of IL-8 gene and dexamethasone did not *affect* the IL-1beta induced transcription of [IL-8] . Regulation IL8 IL1B 8999951 409998 Although the nuclear factor-kappaB (NFkappaB) element regulates only inducible activity of the [IL-8] promoter in *response* to stimulation with , the AP-1 and CCAAT/Enhancer binding transcription factorein (C/EBP) elements influence both basal and inducible activities . Regulation IL8 IL1B 9275483 408058 The *effects* of and TNF alpha on the production of [IL-8] by glomerular endothelial cells were also observed . Regulation IL8 IL1B 9475356 486783 Differential *regulation* of [IL-8] by and TNFalpha in hyaline membrane disease . Regulation IL8 IL1B 9475356 486785 Bronchoalveolar lavage cell cytokine relationships were evaluated and the differential *regulation* of [IL-8] by and TNFalpha was studied in a short-term culture system . Regulation IL8 IL1B 9831176 551453 and interferon-gamma differentially *regulate* release of monocyte chemotactic protein-1 and [interleukin-8] by human bronchial epithelial cells . Regulation IL8 IL1B 9831176 551470 Our results indicate that IFN-gamma and differentially *regulate* the MCP-1 and [IL-8] release by human bronchial epithelial cells . Regulation IL8 IL1R2 2969889 95656 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL8 ITGB2 10590045 572278 As evident from antibody blocking experiments , PF-4 induced adhesion involved PMN expressed L-selectin as well as leukocyte function associated molecule-1 ( LFA-1 ) , whereas [IL-8] *involved* . Regulation IL8 ITGB2 1356557 198029 The *role* of in [IL-8] induced dermal and synovial inflammation . Regulation IL8 ITGB2 7514637 254116 Zymosan induced [IL-8] release from human neutrophils *involves* activation via the receptor and endogenous platelet activating factor as an autocrine modulator . Regulation IL8 LBP 12193231 981029 Thereafter , the *effects* of LPS , soluble CD14 ( sCD14 ) and on the release of interleukin-6 (IL-6) and [IL-8] were studied . Regulation IL8 MAP2K6 20460732 2262924 However , PD98059 ( a MEK1/2 inhibitor ) dramatically down-regulated this cytokine , suggesting *dependent* [IL-8] production . Regulation IL8 STAT4 19001140 1991092 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL8 TLR7 17034424 1683392 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL8 TLR7 17578764 1763656 The aim of this study was to clarify the *role* of different ligands in [IL8] production in NCI-H295R cells . Regulation IL8 TLR7 18312842 1879786 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL8 TLR7 18426885 1926320 however , the [IL-8] response was *independent* of MyD88 dependent signaling . Regulation IL8 TLR7 18544685 1952240 We and others have reported that Toll-like receptor (TLR) proteins are present on human neutrophils and that granulocyte-macrophage colony stimulating factor ( GM-CSF ) treatment enhances [IL-8] ( CXCL8 ) secretion in *response* to stimulation with ligands . Regulation IL8 TLR7 20130217 2213372 Conversely , stable overexpression of Sigirr diminished NF-kappaB mediated [IL-8] *responses* to ligands . Regulation IL8 TLR7 20471186 2294558 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL8 TNF 10079141 597393 In the present study , we investigated the role of [IL-8] and MCP-1 and *regulation* of these chemokines by and IL-1 in LPS induced uveitis in rabbits . Regulation IL8 TNF 10384135 624774 The extents of IL-6 and [IL-8] production in *response* to were greatly augmented by TRX as compared with TNF-alpha alone . Regulation IL8 TNF 10433808 634072 PGE ( 2 ) ( 1 microM or 10 nM ) reduces marrow stromal cell [IL-8] synthesis in *response* to IL-1alpha or . Regulation IL8 TNF 10460229 639654 Human placental cells show enhanced production of [interleukin (IL)-8] in *response* to lipopolysaccharide (LPS) , IL-1 and , but not to IL-6 . Regulation IL8 TNF 10460229 639658 The placental cells also release [IL-8] in a dose dependent manner , in *response* to r- ( recombinant ) IL-1alpha and , but not rIL-6 . Regulation IL8 TNF 10462040 639923 Redox dependent *regulation* of [interleukin-8] by in lung epithelial cells . Regulation IL8 TNF 10617974 657252 Consumption of the n-3 fatty acid docosahexaenoic acid ( DHA ; 22 : 6n-3 ) reduced endothelial expression of vascular cell adhesion molecule 1 ( VCAM-1 ) , E-selectin , intercellular adhesion molecule 1 ( ICAM-1 ) , interleukin 6 (IL-6) , and [IL-8] in *response* to IL-1 , IL-4 , , or bacterial endotoxin , with a half-maximal inhibitory concentration ( IC ( 50 ) ) of 1-25 micromol , ie , in the range of nutritionally achievable plasma concentrations . Regulation IL8 TNF 10728932 579469 *Effects* of and IL-1 beta on mucin , lysozyme , IL-6 and [IL-8] in passage-2 normal human nasal epithelial cells . Regulation IL8 TNF 10795756 689768 CAPAN-1 cells had concentration dependent production of IL-6 and [IL-8] in *response* to both endotoxin and . Regulation IL8 TNF 10795756 689772 CAPAN-2 cells had concentration dependent production of IL-6 and [IL-8] in *response* to . Regulation IL8 TNF 10843739 700319 In contrast with MO , purified LY and non fractionated PBMC expressed [IL-8] in *response* to exogenous , similar to exogenous IL-1alpha and IL-1beta . Regulation IL8 TNF 11191284 761401 *Effect* of IFNgamma , and IL-1beta on viability , butyrate oxidation and [IL-8] secretion . Regulation IL8 TNF 11359438 816233 The inhibition of , IL-6 and [IL-8] *response* was a dose dependent . Regulation IL8 TNF 11597930 870321 Increased transcription of [IL-8] in endothelial cells is differentially *regulated* by and oxidized phospholipids . Regulation IL8 TNF 11597930 870322 To elucidate the molecular mechanisms of Ox-PAPC induced gene expression and to determine whether Ox-PAPC and other inflammatory mediators such as TNF-alpha utilize common signaling pathways , we examined the transcriptional *regulation* of [IL-8] by Ox-PAPC and in human aortic endothelial cells . Regulation IL8 TNF 11597930 870325 Actinomycin D experiments suggested that both Ox-PAPC and *regulate* the expression of [IL-8] at the transcriptional level . Regulation IL8 TNF 12090473 960028 These results suggest that the *effect* of on [IL-8] is responsible for the regulation of the expression of CD44 isoforms . Regulation IL8 TNF 12406900 1054815 In contrast , the response to zymosan or Staphylococcus aureus as well as the interleukin-6 (IL-6) and [IL-8] *responses* to endotoxin were unaffected by ubiquitin . Regulation IL8 TNF 12538454 1049726 Repeated administrations of interleukin (IL)-12 are associated with persistently elevated plasma levels of IL-10 and declining IFN-gamma , , IL-6 , and [IL-8] *responses* . Regulation IL8 TNF 12780691 1095582 In addition , we highlight the *role* of in [IL-8] secretion in MDR-TB patients . Regulation IL8 TNF 14506934 1145025 This study investigated the possible *effects* of IL-1alpha , , protein kinase C ( PKC ) activators ( TPA ) , and db-cyclic adenosine monophosphate ( cAMP ) on [IL-8] and GRO-alpha production by immortalized GC1a and granulosa-lutein cells . Regulation IL8 TNF 15034071 1223624 Elafin and murine SLPI also reduced endothelial [IL-8] release in *response* to oxidized low density lipoprotein , LPS , and and macrophage TNF-alpha production in response to LPS . Regulation IL8 TNF 15081568 1234161 The *effect* of , PMA , and LPS on plasma and cell associated [IL-8] in human leukocytes . Regulation IL8 TNF 15322027 1286726 Our experiments were designed to explore the mechanism of effect of L. reuteri in the human epithelial cell lines T84 and HT29 on cytokine and NGF synthesis and [IL-8] *response* to . Regulation IL8 TNF 15652492 1364241 We investigated the *effect* of on [interleukin-8 (IL-8)] and endothelin-1 (ET-1) expression , and their different signal transduction pathways . Regulation IL8 TNF 15664665 1365287 Similar to BK , the calcium ionophore A23187 also upregulated the stimulatory *effect* of IL-1beta and on [IL-8] production . Regulation IL8 TNF 15723090 1396084 Similarly , IKK beta ( KA ) and I kappa B alpha delta N overexpression also inhibited IL-1beta- and *dependent* increases in ICAM-1 , [IL-8] and GM-CSF in addition to IL-1beta mediated increases in cyclooxygenase-2 expression , whereas IKK alpha ( KM ) overexpression had little effect on these outputs . Regulation IL8 TNF 15818692 1393486 Nevertheless , the C43S TRAPS fibroblasts were capable of producing interleukin-6 (IL-6) and [IL-8] in *response* to . Regulation IL8 TNF 1601032 189069 [IL-8] production was *independent* of and of virulence of the strain of M. tuberculosis . Regulation IL8 TNF 1628417 191786 The cytokine [IL-8] -- predominantly an activator and chemotactic factor for circulating polymorphonuclear neutrophil leucocytes -- is produced in *response* to in vitro , and high circulating levels of IL-8 are found in septic primates . Regulation IL8 TNF 16322091 1533063 The anti-inflammatory effect extends to both bacterial and host derived proinflammatory stimuli , since prior infection with EPEC suppressed the [IL-8] *response* to , IL-1beta , and enterohemorrhagic E. coli flagellin . Regulation IL8 TNF 16324699 1503395 Differential *regulation* of [interleukin-8] gene transcription by death receptor 3 (DR3) and type I receptor ( TNFRI ) . Regulation IL8 TNF 16326999 1503508 [IL-8] production in *response* to activation by unrelated and PMA signaling pathways is also inhibited , indicating a broad spanning tolerance . Regulation IL8 TNF 16429233 1534090 Cellular activity of [IL8] is mediated by the receptor CXCR2 , and transcription of IL8 is *controlled* by the cytokine tumour necrosis factor ( ) . Regulation IL8 TNF 16522458 1531300 The capacity of IL-17E to enhance GM-CSF and [CXCL-8] *responses* to was accompanied by production and secretion of both proteins by lung fibroblasts . Regulation IL8 TNF 17317104 1747546 Consistently , a site mutation of Rel A ( Ser ( 276 ) to Ala ) in RelA-deficient embryonic fibroblasts failed to activate [IL-8] Luciferase activity in *response* to . Regulation IL8 TNF 17784835 1790515 In agreement with this observation , induction of [interleukin-8 (IL-8)] in *response* to was seen only in differentiated SNUhES3 cells . Regulation IL8 TNF 18544909 1923600 In conclusion , [IL-8] production was predominantly induced in THP-1 cells following allergen stimulation , and MAPK pathways and were *involved* in the IL-8 production induced by DNCB and NiSO ( 4 ) . Regulation IL8 TNF 18556801 1940713 In vitro , PPARgamma agonists reduced [IL-8] and MMP-9 release from airway epithelial cells in *response* to PAO1 or stimulation . Regulation IL8 TNF 18571457 1940835 Systematic analysis highlights the key *role* of kinase signaling for [IL-8] induction by macrophage-like THP-1 cells under influence of Borrelia burgdorferi lysates . Regulation IL8 TNF 18612822 2028038 Saccharomyces boulardii blocked *regulation* of PPAR-gamma and [IL-8] through disruption of TNF-alpha mediated nuclear factor kappa B (NF-kappaB) activation . Regulation IL8 TNF 18644884 1960195 However , the increase in [IL-8] secretion was *independent* of Campylobacter stimulated secretion . Regulation IL8 TNF 18684450 2059331 We examined the *effects* of and IL-10 on the expression of IL-6 or [IL-8] by real-time RT-PCR and ELISA . Regulation IL8 TNF 18978040 2015151 CF and non-CF cell lines produced similar levels of IL-8 at baseline and equally increased [IL-8] secretion in *response* to IL-1beta , , and the Toll-like receptor 2 agonist Pam3Cys . Regulation IL8 TNF 19039059 1998765 The cell-wall preparation induced dose dependent IL-1beta , , IL-6 , and [IL-8] *responses* in macrophages . Regulation IL8 TNF 19583958 2162568 SB202190 successfully suppressed IL-6 , [IL-8] , PGE2 , and PGF2alpha secretion in macrophage exposed AF cells in *response* to . Regulation IL8 TNF 19648110 2138426 Thus , MKP-1 attenuates *dependent* activation of p38 MAPK , induction of [IL-8] expression , and NF-kappaB dependent transcription . Regulation IL8 TNF 19887769 2197293 The present data do not support the hypothesis that ibuprofen down-regulates [IL-8] production in *response* to and IL-1beta in CF respiratory epithelium . Regulation IL8 TNF 19926933 2167185 The IL-8 secretion induced by hydrogen peroxide and by IL-1beta was not suppressed by IFF , suggesting that the inhibitory effect of isoflavone was specific for the induced *regulation* of [IL-8] . Regulation IL8 TNF 20406675 2267520 The *effects* of on [IL-8] and IL-6 or NO production were stronger upon combination with IL-1beta or IFN-gamma , respectively , whereas cells were unaffected by the presence of LPS . Regulation IL8 TNF 20507154 2276734 Lipopolysaccharide (LPS) stimulated fibroblasts incubated with PGA-alpha-MSH showed an early time dependent inhibition of , a late induction of IL-10 , and no *effect* on [IL-8] secretion . Regulation IL8 TNF 20845069 2474769 Synergistic *effect* of and hydrogen peroxide on the induction of [IL-8] production in human intestinal Caco-2 cells . Regulation IL8 TNF 21271591 2380808 [Interleukin-8] production in *response* to by cholesteatoma keratinocytes in cell culture . Regulation IL8 TNF 21271591 2380810 Keratinocytes harvested from acquired cholesteatoma and grown in cell culture will demonstrate increased [interleukin-8 (IL-8)] production in *response* to as compared with a control keratinocyte cell line . Regulation IL8 TNF 21673619 2538698 Prior macrophage exposure increased the secretion of [IL-8] and VEGF in *response* to stimulation whereas IL-6 production was increased in response to IL-1ß . Regulation IL8 TNF 21995333 2507621 Moreover induction of IL-6 and [IL-8] was primarily *regulated* by MC-derived . Regulation IL8 TNF 22526394 2595906 The human colon cell line , HT-29 , increased [interleukin (IL)-8] expression in *response* to recombinant human , but not in response to bacterial ligands and interferon (IFN)-gamma . Regulation IL8 TNF 22988345 2674364 The EGF receptor and HER2 participate in *dependent* MAPK activation and [IL-8] secretion in intestinal epithelial cells . Regulation IL8 TNF 23800251 2808007 Finally , CCL20 and [CXCL8] responded synergistically in *response* to EGF and in OVCAR-3 and SKOV-3 cells . Regulation IL8 TNF 24129565 2875074 Chromatin immunoprecipitation ( ChIP ) assays demonstrated decreased NF-?B binding to the promoters of IL-6 , [IL-8] , and I?Ba in *response* to with TGF-ß1 pretreatment . Regulation IL8 TNF 24226202 2921150 Hierarchical analysis of genes using RNA interference showed that both and IL-1ß *regulate* the expression of [IL-8] through independent pathways in response to reduced hydration . Regulation IL8 TNF 24455739 2884496 Lactobacilli reduce chemokine [IL-8] production in *response* to and Salmonella challenge of Caco-2 cells . Regulation IL8 TNF 3486658 59993 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL8 TNF 3491252 65998 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL8 TNF 7594569 325866 This study shows that the pathways leading to cell death and [IL-8] production in *response* to Fas Ag ligation and were similar with regard to their requirements for new gene expression , protein synthesis , and protein kinase activity . Regulation IL8 TNF 7810274 284969 The potent neutrophil activator and chemotaxin [interleukin-8 (IL-8)] is released in *response* to and recent interest has focussed on its possible role in producing the characteristic peripheral blood neutrophilia and liver neutrophil infiltrate in alcoholic hepatitis . Regulation IL8 TNF 7880974 289096 Both p55 and p75 receptors on dermal and gingival fibroblasts were also *involved* in TNF-alpha mediated DNA synthesis and IL-6 , [IL-8] and PGE2 release , although differences in the levels of DNA synthesis and release of inflammatory cytokines and PGE2 were observed between the three fibroblast types . Regulation IL8 TNF 7934096 275458 A local production of these cytokines can not be excluded , because interleukin-6 and [interleukin-8] are produced by stimulated macrophages and monocytes in *response* to and interleukin-1 beta . Regulation IL8 TNF 7943343 276426 The *effects* of on [interleukin-8 (IL-8)] expression and generation were examined in primary cultured human airway epithelial cells ( HAEC ) and a human lung epithelial cell line ( A549 ) . Regulation IL8 TNF 7986155 282366 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL8 TNF 8501341 220942 The *role* of in [interleukin (IL)-8] release in septicemia in the baboon ( 2-h infusion of live Escherichia coli , 5 x 10 ( 8 ) cfu/kg ) was investigated . Regulation IL8 TNF 9275483 408057 The *effects* of IL-1 beta and on the production of [IL-8] by glomerular endothelial cells were also observed . Regulation IL8 TNF 9375973 465377 IL-13 , but not IL-10 , significantly enhanced [IL-8] and MCP-1 release in *response* to IL-1alpha or . Regulation IL8 TNF 9407069 470795 Differential *regulation* of [interleukin-8] and intercellular adhesion molecule-1 by H2O2 and in endothelial and epithelial cells . Regulation IL8 TNF 9475356 486782 Differential *regulation* of [IL-8] by IL-1beta and in hyaline membrane disease . Regulation IL8 TNF 9475356 486784 Bronchoalveolar lavage cell cytokine relationships were evaluated and the differential *regulation* of [IL-8] by IL-1beta and was studied in a short-term culture system . Regulation IL8 TNF 9574558 502543 To assess the interactions of multiple cytokines at the level of inflammatory effector cells , we examined the *effects* of on the expression of two [IL-8Rs] ( CXCR1 and CXCR2 ) on polymorphonuclear leukocytes ( PMNs ) . Regulation IL8 TNF 9660302 517297 Inactivation of the NF-kappaB and 3'NF-IL-6 DNA binding sites decreased IL-8 gene transcriptional activation in response to TNF while inactivation of the 5'NF-IL-6 binding site increased [IL-8] gene transcriptional activity in *response* to . Regulation IL8 TNF 9697747 524699 [Interleukin-8] production by human monocytic cells in response to staphylococcal exotoxins is direct and *independent* of interleukin-1 and . Regulation IL8 TNF 9712752 527386 Our findings support a *role* for P. haemolytica LPS and in the induction of [IL-8] from bovine alveolar macrophages . Regulation IL8 TNF 9806041 544723 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation IL8 TNF 9830008 551264 We previously demonstrated that and H2O2 differentially *regulate* [interleukin-8 (IL-8)] and intercellular adhesion molecule ( ICAM-1 ) gene expression in endothelial and epithelial cells . Regulation IL8 TP63 15126418 1244848 These findings suggest that would *regulate* the cell adhesive property through ICAM-1/LFA-1 interaction and the production of IL-6 and [IL-8] , probably in all TEC subtypes . Regulation IL9 ALOX5 8722494 373706 *Effects* of <5-lipoxygenase> inhibitors on [interleukin] production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors . Regulation IL9 IL1B 10984364 732180 We also investigated the *role* of and TNF-alpha in the release of [IL-9] from human peripheral blood eosinophils . Regulation IL9 IL1B 14617515 1200677 Hyperoxia did not affect *dependent* degradation of the [interleukin] receptor associated kinase differently from treatment with IL-beta alone . Regulation IL9 IL1R2 2969889 95658 Modulation of expression and [interleukin-1] *response* in fibroblasts by platelet derived growth factor . Regulation IL9 STAT4 19001140 1991093 We investigated the potential roles of Tpl2 in T cells and found that it was induced by [interleukin-12] in human and mouse T cells in a *dependent* manner . Regulation IL9 TLR7 17034424 1683402 In this study we have shown that , whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4 , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or [interleukin-12] *responses* to subsequent stimulation . Regulation IL9 TLR7 18312842 1879796 Toxoplasma profilin is essential for host cell invasion and *dependent* induction of an [interleukin-12] response . Regulation IL9 TLR7 20471186 2294568 *Involvement* of in baculovirus induced [interleukin-12] gene expression in avian macrophage-like cell line HD11 . Regulation IL9 TNF 10984364 732179 We also investigated the *role* of IL-1beta and in the release of [IL-9] from human peripheral blood eosinophils . Regulation IL9 TNF 3486658 59994 We have investigated the *effect* of on the release of [interleukin-1] and PGE2 from murine resident peritoneal macrophages . Regulation IL9 TNF 3491252 65999 The *effects* of on the production of [interleukin-1] by macrophages . Regulation IL9 TNF 7986155 282367 and [interleukin-1] *regulation* by lipopolysaccharide pretreatment . Regulation IL9 TNF 9806041 544726 *Regulation* of [interleukin-12] by interleukin-10 , transforming growth factor-beta , , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra . Regulation ILK CTGF 17498677 1744482 In this study , we investigated the role of extracellular regulating kinase 1/2 ( ERK1/2 ) and phosphatidylinositol 3-kinase (PI3-K) in the *regulation* of [ILK] expression by in HK-2 cells . Regulation ILK CTGF 17498677 1744485 Induction of [ILK] in *response* to was studied at the mRNA level by real-time PCR and protein by immunoblotting . Regulation ILK MAP2K6 17498677 1744537 Chemical inhibitors were used to assess the *role* of , PI3-K , and P38 MAPK signaling pathways in induction of [ILK] by CTGF . Regulation INCENP STK39 18083840 1837827 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation INHBA EGLN3 22778395 2639716 The prolyl hydroxylase identifies proinflammatory macrophages and its expression is *regulated* by [activin A] . Regulation INHBA IL1B 17636213 1770721 In the present study , the *effect* of , 17-beta estradiol ( E2 ) , and progesterone ( Pr ) on [activin A] and follistatin (FS) secretion from cultured human endometrial stromal cells ( HESCs ) is evaluated . Regulation INHBA TNF 23385491 2818517 To test the hypothesis that activin A was involved in the pathophysiology of amnionitis , we evaluated the *effects* of and lipopolysaccharide on [activin A] production in human amniotic epithelial cells , and the effects of activin A on the expression of collagen mRNA in amniotic mesenchymal cells . Regulation INHBB INHBA 16434038 1554425 The purpose of this study was to investigate the *effects* of and inhibin A on granulosa cell expression of [inhibin beta-B-subunit] , FSH receptor (FSHR) , and LH receptor (LHR) . Regulation INHBB INS 19491194 2136178 [Inhibin betaB] expression in murine adipose tissue and its *regulation* by leptin , and dexamethasone . Regulation INHBB MIR34A 21655280 2442317 mediated *regulation* of [INHBB] and Met may collectively contribute to the suppression of hepatocyte proliferation . Regulation INMT CTGF 20369462 2238574 Pioglitazone may negatively *regulate* [TEMT] through inhibiting the expression of . Regulation INMT CTGF 22340339 2520831 The aim of this study was to investigate whether C3a , C5a can regulate TEMT by transforming growth factor-ß1 ( TGF-ß ) signaling pathway and the *effects* of C3a and C5a receptor antagonists ( C3aRA and C5aRA ) on C3a- and C5a induced [TEMT] . Regulation INPP4B EPHB2 22895072 2692356 Taken together , our data suggest that *dependent* induction of [INPP4B] triggers the development of a tumor-resistance phenotype via Akt signaling and identify INPP4B as a potentially important target molecule for resolving the radioresistance of cancer cells . Regulation INS ADRB2 1337737 208041 Further , IAPP inhibited the [insulin] secretory *response* to stimulation . Regulation INS ADRB2 14693408 1194884 Further studies of the expression of the allelic receptor in islet cells may help to resolve the *role* of in [insulin] secretion . Regulation INS AGR2 7018149 16054 Verapamil significantly inhibited the acute [insulin] *response* ( AIR , mean change from 3-10 min ) to glucose ( 5 g ) , as well as the AIR and ( acute glucagon response ) to arginine ( 5 g ) . Regulation INS ARSA 6757082 24101 In summary , the discrepant *effect* of on C-peptide and [insulin] responses suggest that changes of insulin metabolism may be involved in the mechanism of ASA induced increase in peripheral insulin levels . Regulation INS ARSA 6989847 11058 To investigate whether prostaglandins (PGs) play a role in the regulation of insulin secretion during starvation , we have studied the *effects* of two inhibitors of PG synthesis , indomethacin (INDO) and , on plasma [insulin] during a 72-h fast . Regulation INS CA12 9733757 531009 Expression of carbonic anhydrase V in pancreatic beta cells suggests *role* for mitochondrial in [insulin] secretion . Regulation INS CAPN8 15877869 1405886 Lactacystin and calpain inhibitor I , but not isovaleryl-L-carnitine , raised insulin secretion in control islets , indicating that proteasome and cysteinyl cathepsin(s) , but not , are *involved* in fetal [insulin] secretion . Regulation INS EPHB2 16210359 1501024 These results suggest that both and PI3 kinase signaling are *involved* in [insulin] stimulated granulosa cell proliferation . Regulation INS EPHB2 16931794 1633026 This study provides direct evidence for a novel molecular mechanism by which oxidants can induce insulin resistance via S-glutathiolation of p21ras and *dependent* inhibition of [insulin] signaling . Regulation INS EPHB2 18344986 1886584 [Insulin] expression was also increased in an *dependent* manner in cultured Drosophila central nervous system ( CNS ) cells and in rat pancreatic cells treated with sNPF or NPY peptide , respectively . Regulation INS EPHB2 21673097 2455367 Our results indicate that GPER activation of the epidermal growth factor receptor and in response to estradiol treatment *plays* a critical role in the secretion of [insulin] from ß-cells . Regulation INS EPHB2 22778134 2659958 Furthermore , knockdown of c-Cbl in INS-1 cells , a rat ß-cell line , also increased [insulin] biosynthesis and glucose stimulated secretion in an *dependent* manner . Regulation INS EPHB2 23373714 2764276 These findings suggest that signalling *plays* an important role in the regulation of [insulin] signals in muscle cells under ER stress . Regulation INS EPHB2 9155017 431567 Initiation factor eIF-4E is a regulatory phosphoprotein whose phosphorylation is increased by [insulin] in an *dependent* manner . Regulation INS F2R 9851940 554484 The resistance of the alpha1B-CAM hearts was not due to alpha1B-AR mediated preconditioning , as the [Ins] ( 1,4,5 ) P3 *response* to activation during reperfusion was not different between the 2 groups . Regulation INS FAS 10778881 687037 However , the *effects* of on [insulin] gene expression are controversial . Regulation INS FAS 10778881 687038 We hypothesized that adversely *affect* [insulin] gene expression only in the presence of elevated glucose concentrations . Regulation INS FAS 16487789 1524866 The present review also describes the possible *effects* of on [insulin] signaling . Regulation INS FAS 19843871 2299420 These data demonstrate that differently *regulate* amylin and [insulin] expression and induce both amylin and insulin release . Regulation INS FBXO32 24438646 2907315 Abundance of , but not MuRF1 , was greater in 26- than 6-d-old pigs and was not *affected* by [insulin] , amino acids , or leucine . Regulation INS FOXA1 19445897 2090620 *Role* of in mitochondrial citrate carrier gene expression and [insulin] secretion . Regulation INS FOXA1 19445897 2090629 These results show that *plays* a role in the transcriptional regulation of CIC and in [insulin] secretion . Regulation INS FOXO1 11696581 877506 These findings are consistent with the possibility that is *involved* in [insulin] regulation of glucose production by mediating the ability of insulin to decrease the glucocorticoid/cAMP response of G6p . Regulation INS FOXO1 14664696 1210729 The presence of these redundant mechanisms supports the concept that the regulation of function *plays* a critical role in [insulin] and growth factor action . Regulation INS FOXO1 16885156 1613825 [Insulin] regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes : *roles* of and sterol regulatory element binding protein 1c . Regulation INS FOXO1 18838380 1993910 We report that insulin activates the redox enzyme activity of p66 ( Shc ) specifically in adipocytes and that p66 ( Shc ) -generated ROS regulate insulin signaling through multiple mechanisms , including AKT phosphorylation , localization , and *regulation* of selected [insulin] target genes . Regulation INS FOXO1 19297333 2073261 In 3T3-L1 adipocytes , [insulin] *controls* nucleo-cytoplasmic shuttling of and regulates its interaction with endogenous ATGL promotors . Regulation INS FOXO1 21335550 2411096 Nucleo-cytosolic shuttling of directly *regulates* mouse [Ins2] but not Ins1 gene expression in pancreatic beta cells ( MIN6 ) . Regulation INS FOXO1 24406377 2926929 The neurodegenerative effects of selenium are inhibited by and PINK1/PTEN *regulation* of [insulin/insulin-like] growth factor signaling in Caenorhabditis elegans . Regulation INS GLP1R 12923570 1131153 Engineering physiologically *regulated* [insulin] secretion in non-beta cells by expressing . Regulation INS GLP1R 22101168 2541012 *plays* a critical role in geniposide regulated [insulin] secretion in INS-1 cells . Regulation INS GLP1R 22101168 2541015 To explore the *role* of the ( GLP-1R ) in geniposide regulated [insulin] secretion in rat INS-1 insulinoma cells . Regulation INS GPR115 23211512 2731012 Pancreatic ß-cells regulate glucose homeostasis by secreting [insulin] in *response* to glucose elevation and activation . Regulation INS GPR115 23331570 2775581 fatty acid receptor 1 ( GPR40/FFAR1 ) *regulates* free fatty acid induced [insulin] secretion . Regulation INS GPR132 23211512 2731001 Pancreatic ß-cells regulate glucose homeostasis by secreting [insulin] in *response* to glucose elevation and activation . Regulation INS GPR132 23331570 2775570 fatty acid receptor 1 ( GPR40/FFAR1 ) *regulates* free fatty acid induced [insulin] secretion . Regulation INS GPR87 23211512 2731081 Pancreatic ß-cells regulate glucose homeostasis by secreting [insulin] in *response* to glucose elevation and activation . Regulation INS GPR87 23331570 2775651 fatty acid receptor 1 ( GPR40/FFAR1 ) *regulates* free fatty acid induced [insulin] secretion . Regulation INS ID1 21940780 2487660 Here , we investigated the *role* of in [insulin] secretion and glucose homeostasis . Regulation INS IGFBP1 12042554 949819 If intrauterine growth is related to the risk of developing adult diseases , IGF-I , , and leptin may be *involved* in the underlying processes.1131-1135 [insulin] like growth factors , leptin , umbilical cord plasma , birth weight . Regulation INS IGFBP1 15070833 1272811 During pregnancy , the [insulin-like growth factors (IGFs)] , which are known to be critically involved in placental development , are *controlled* by a binding produced by maternal decidualized endometrium . Regulation INS IGFBP1 21642764 2599075 LAN did not modify the GH , [insulin] , glucagon , glucose , and *responses* to ARG . Regulation INS IGFBP1 7511134 250039 It is proposed that the specific secretion pattern of is not directly dependent on body fat mass but is *regulated* by [insulin] in both obese and non-obese patients . Regulation INS IL1B 10903798 713222 Although IL-12 induces IL-18R expression in Th1 and B lymphocytes , 24-hours rmIL-12 preincubation neither sensitized islets to effects of 10 nM of rm or rrIL-18 alone nor primed the islets to *actions* on [insulin] release and NO production . Regulation INS IL1B 10919268 717210 The early induction of PLD1 probably contributes to the early stimulatory *effects* of on islet [insulin] release . Regulation INS IL1B 11171124 783855 The enhancing *effects* of and PDGF-BB on [Ins] ( X ) P accumulation , Ca2+ mobilization and B ( max ) were attenuated by PD98059 [ an inhibitor of activation of mitogen activated protein kinase (MAPK) kinase , MEK ] and cycloheximide ( an inhibitor of protein synthesis ) , suggesting that IL-1beta may share a common signalling pathway with PDGF-BB via protein synthesis . Regulation INS IL1B 11735275 885761 We tested the in vitro *effects* of , tumor necrosis factor (TNF)alpha , and interferon (IFN)gamma on glucose stimulated [insulin] release in the MIN6 beta-cell line and correlated metabolic dysfunction with NO production and rates of apoptosis . Regulation INS IL1B 11989973 936436 The stimulatory *effect* of on the [insulin] secretion of rat pancreatic islet is not related with iNOS pathway . Regulation INS IL1B 11989973 936438 The stimulatory *effect* of on the [insulin] secretion of rat islets was not prevented by NMMA . Regulation INS IL1B 11989973 936442 These results suggested that the stimulatory *effect* of on the [insulin] secretion of rat islets is independent of iNOS related NO production of IL-1beta and the enzyme activity of nitric oxide synthase . Regulation INS IL1B 12021199 943035 Lisofylline ( LSF ) , an anti-inflammatory agent , has been shown to protect pancreatic islets from induced inhibitory *effects* on [insulin] release . Regulation INS IL1B 15561930 1341213 We next analyzed if suppressor of cytokine signaling (SOCS)-3 , which can be induced by multiple cytokines and which we identified as an insulin action inhibitor , was implicated in the inhibitory *effect* on [insulin] signaling in these cells . Regulation INS IL1B 1564418 184913 As shown in this paper , fusidin also prevents the inhibitory effect of human recombinant ( rIL-1 beta ) and the stimulatory *effect* of human rIL-6 , on glucose induced [insulin] production in vitro by normal rat pancreatic islets . Regulation INS IL1B 16865359 1592774 We evaluated the chronic *effect* ( 1-10 days ) of ( 0.1-20 ng/ml ) on [insulin] signalling in differentiating 3T3-F442A and differentiated 3T3-L1 murine adipocytes and in human adipocytes . Regulation INS IL1B 1875016 165409 The *effect* of recombinant human ( rhIL-1b ) on in vivo [insulin] secretion was examined in intact and adrenalectomized ( ADX ) rats under conscious and pentobarbital anesthetized conditions . Regulation INS IL1B 1991576 154087 It was found that the trypsin inhibitor N alpha-p-tosyl-L-lysine chloromethyl ketone ( TLCK ) counteracted the acute stimulatory *effects* of on islet glucose oxidation , [insulin] release , and biosynthesis . Regulation INS IL1B 2103305 150443 Previous studies have demonstrated a stimulatory *effect* of on [insulin] and glucagon release from the perfused rat pancreas , accompanied by selective lysis of 20 % of beta-cells as assessed by electronmicroscopy . Regulation INS IL1B 2137789 128802 The *effect* of the cytokine on the [insulin] secretory responsiveness of single beta-cells ( HIT-T15 ) was investigated . Regulation INS IL1B 2406177 128064 We recently reported a potentiating *effect* of recombinant human on glucose stimulated [insulin] release from the isolated perfused pancreas . Regulation INS IL1B 2406177 128067 The potentiating *effect* of recombinant on [insulin] secretion was evident even after discontinued perfusion with the cytokine , suggesting a priming effect on B-cell function . Regulation INS IL1B 2508388 118925 Modulation of calcium flux influences *effects* on [insulin] release from isolated islets of Langerhans . Regulation INS IL1B 3289298 93061 The acute *effects* of recombinant human ( rIL-1 ) on basal and glucose stimulated [insulin] release were investigated in the isolated perfused pancreas . Regulation INS IL1B 7514190 254023 Inhibitors of NO generation , aminoguanidine or NG-nitro-L-arginine , blocked this cytokine induced NO generation , but did not prevent the suppressive *effect* of plus IFN-gamma plus TNF-alpha on [insulin] release and content . Regulation INS IL1B 7556877 323433 The aim of the present study was to investigate the mechanisms responsible for the acute , stimulatory *effects* of ( rIL-1 beta ; 1 ng/ml ) on [insulin] release from mouse pancreatic islets . Regulation INS IL1B 7570112 324921 [ Inhibitory *effect* of on [insulin] release from isolated rat pancreatic islets and the reversal action of testosterone ] . Regulation INS IL1B 7570112 324922 This inhibitory *effect* of on [insulin] release could be reversed by testosterone ( 10 ( -10 ) mol/L ) , which was accompanied by an increase of the insulin content in islet cells . Regulation INS IL1B 7679657 211292 The inhibitory *effect* of SIN-1 or on [insulin] secretion seems to depend to a small extent on decreased islet cyclic AMP , though sustained increases in nitric oxide or depleted islet GTP may directly affect the secretory process . Regulation INS IL1B 7959906 278697 All three vitamin D derivatives counteracted the suppressive *effect* of on medium [insulin] accumulation , 1,25- ( OH ) 2D3 being active at concentrations down to 0.1 nM , i.e. , 1-2 orders of magnitude more efficacious than the analogues . Regulation INS IL1B 7959906 278698 However , only KH1060 opposed the suppressive *effect* of on islet glucose stimulated [insulin] secretion and glucose oxidation rate despite the fact that KH1060 itself reduced the islet DNA and insulin content by approximately 10 % and 30 % , respectively . Regulation INS IL1B 8405744 232435 However , at a 100-fold molar excess the interleukin-1 receptor antagonist did not antagonise the potentiating *effect* of on rat islet [insulin] accumulation during 3 and 6 h of exposure or of interleukin-1 beta induced inhibition of insulin release after 24 h . Regulation INS IL1B 8630528 361258 The aim of this study was to investigate if D-glucose mediated modulation of *effects* on [insulin] release from isolated rat islets was related to modulation of nitric oxide production . Regulation INS IL1B 8630528 361259 This effect was dissociated from *action* on [insulin] release , since a relative protection against interleukin-1 beta effects on acute insulin release was found at high ( 28 mmol/l ) concentrations of D-glucose , and blocking nitrite production by the L-arginine analog aminoguanidine , which selectively inhibits the cytokine-inducible nitric oxide synthase , did not result in protection against the inhibitory action of interleukin-1 beta . Regulation INS IL1B 8635652 362076 Isolated islets of Langerhans in vitro from Wistar-Kyoto/Møllegården ( WK/Mol ) rats were sensitive to the inhibitory *effect* of on accumulated and acute [insulin] secretion , whereas islets from Brown Norway/Charles River ( BN/CR ) rats were resistant . Regulation INS IL1B 8655918 343051 The pH dependence of *effects* on [insulin] secretion in HIT cells . Regulation INS IL1B 8655918 343052 We have examined a hypothesis that the *effects* of recombinant human on [insulin] secretion may depend upon the condition of intracellular pH levels in hamster clonal beta-cell line , HIT-T 15 cells . Regulation INS IL1B 8754764 374420 Islets that were cultured for 18 h in the presence of IL-1 beta and epiandrosterone ( EA ) or dehydroepiandrosterone ( DHEA ) and then washed responded with a concentration dependent reversal of the *effects* of on [insulin] release in the presence of a glucose or glucose plus isobutylmethylxanthine stimulus . Regulation INS IL1B 8828463 385392 We examined the *effects* of IL-1 alpha and on [insulin] and insulin-like growth factor I (IGF-I) stimulation of cell growth and found that both IL-1s inhibited anchorage dependent and independent growth of MCF-7 breast cancer cells . Regulation INS IL1B 8922366 397135 Dual functional *effects* of on purine nucleotides and [insulin] secretion in rat islets and INS-1 cells . Regulation INS IL1B 9245483 446670 Incubation of newborn rat islets for 24 h in the presence of 150 pg/ml IL-1beta revealed that dexamethasone dose-dependently attenuated the inhibitory *effect* of on [insulin] release in response to a 2-h glucose challenge . Regulation INS IL1B 9275497 408059 The *effects* of and/or NA on [insulin] release and nitric oxide ( NO ) production and 3H-thymidine incorporation were studied . Regulation INS IRS4 12639902 1068745 The purpose of the present study was to analyze the expression of IRS-4 in rat muscle and human skeletal muscle cells and assess *involvement* of in initial [insulin] signaling . Regulation INS IRS4 1712770 161255 These results provide further evidence for a *role* of in [insulin] signaling . Regulation INS JAG1 9338087 345211 had no *effect* on resting plasma levels of hGH , [insulin] or cortisol . Regulation INS MAP2K6 23217386 2707871 This study was to investigate the *roles* of ( MEK) 1 and 2 in the regulation of human [insulin-] and insulin glargine induced proliferation of human bladder cancer T24 cells . Regulation INS MAP2K6 9645686 514767 [Insulin] induction of protein kinase C alpha expression is independent of insulin receptor Tyr1162/1163 residues and *involves* 1 and sustained activation of nuclear p44MAPK . Regulation INS PLAU 12008951 940754 In breast stroma is predominantly expressed by fibroblasts located in the near vicinity of tumor cells , and fibroblast derived [insulin-like growth factor-1 (IGF-1)] may be *involved* in inhibiting the expression of uPA in these fibroblasts . Regulation INS RASD1 22700767 2633816 The regulation of expression by glucocorticoids and prolactin *controls* peripartum maternal [insulin] secretion . Regulation INS RGS2 9794454 543056 These results suggest a potential *role* for in modulating GIP mediated [insulin] secretion in pancreatic islet cells . Regulation INS SPHK1 17265031 1704158 is *involved* in [insulin] signalling and plays an important role in the regulation of glucose and fat metabolism ; Regulation INS SPHK1 22155656 2542801 To evaluate the *role* of in [insulin] secretion , we used stable transfection to knock down the expression of the Sphk1 gene in the rat insulinoma INS-1 832/13 cell line . Regulation INS STK39 19046565 1999031 The mammalian target of rapamycin (mTOR) *plays* a central role in [insulin] signaling and cell growth , through two distinct complexes with its subunits raptor or rictor . Regulation INS TGM2 2408879 48610 *Role* of in [insulin] release . Regulation INS TNF 11735091 885664 Anthropometric measurements , fasting plasma glucose , insulin , lipoprotein concentrations , glucose , and [insulin] *responses* to OGTT , , and leptin concentrations were similar between the genotype at the -308 site both in hypertensive and normotensive groups . Regulation INS TNF 11735275 885759 We tested the in vitro *effects* of interleukin (IL)-1 beta , , and interferon (IFN)gamma on glucose stimulated [insulin] release in the MIN6 beta-cell line and correlated metabolic dysfunction with NO production and rates of apoptosis . Regulation INS TNF 15146098 1247741 This review will discuss the *regulation* of [insulin] responses by and evidence supporting the hypothesis that over expression of TNF-alpha plays a role in the pathophysiology of insulin resistance . Regulation INS TNF 16080843 1442760 The synergistic *effect* of and leptin may induce [insulin] secretion , which in turn leads to insulin resistance . Regulation INS TNF 16114068 1460993 We used RINr1046-38 ( RIN ) insulin producing beta-cells , which constitutively express calbindin-D(28k) , to characterize the *effect* of on apoptosis , replication , [insulin] release , and gene and protein expression . Regulation INS TNF 16117322 1449134 *Effects* of on [insulin] stimulated amino acid transport in cultured rat hepatocytes . Regulation INS TNF 16170397 1457162 Multiple regression analysis demonstrated the important *role* of in the regulation of both the insulin resistance and in the secretion of [insulin] in women . Regulation INS TNF 19690174 2144413 While TNF-alpha treatment increased MAP4K4 mRNA expression by 33 +/- 5 % , knockdown of MAP4K4 by siRNA protected beta cells against the detrimental *effects* of on both [insulin] secretion and signaling . Regulation INS TNF 20576518 2285476 We have associated functional and molecular studies of insulin and leptin to investigate the *effect* of on central [insulin] and leptin signaling in rats pre treated with PTP1B-ASO . Regulation INS TNF 7514190 254021 Inhibitors of NO generation , aminoguanidine or NG-nitro-L-arginine , blocked this cytokine induced NO generation , but did not prevent the suppressive *effect* of IL-1 beta plus IFN-gamma plus on [insulin] release and content . Regulation INS TNF 8130898 251452 In contrast , we observed that the predominant *effect* of low-dose IL-1 and when administered separately was the stimulation of [insulin] release . Regulation INS TNF 8543058 338814 did not *affect* glucose induced acute [insulin] secretion ( 30 min ) . Regulation INS TNF 8549863 346490 The aim of this study was to define the *effects* of and interferon-gamma (IFN) on nitric oxide production , [insulin] secretion , and DNA damage in islets from unweaned rats . Regulation INS TNF 8783331 380497 Cryopreservation did not significantly modify the hormone response to glucose but it partially reversed the induced inhibitory *effect* on [insulin] release in the presence of 20 mM glucose . Regulation INS TNF 9421370 480944 *Effects* of cell-permeable ceramides and on [insulin] signaling and glucose uptake in 3T3-L1 adipocytes . Regulation INS TNF 9510167 491834 The IL-1R antagonist protein completely prevents + LPS induced nitrite production , iNOS expression and the inhibitory *effects* on glucose stimulated [insulin] secretion by rat islets . Regulation INS TNF 9510167 491836 Resident macrophages appear to be the source of IL-1 , as a 7-day culture of rat islets at 24 degrees C ( conditions known to deplete islets of lymphoid cells ) prevents + LPS induced iNOS expression , nitrite production , and the inhibitory *effects* on [insulin] secretion . Regulation INS TNS1 1425888 202312 The *effect* of nicotine absorbed and from cigarette smoking on [insulin] secretion and action in Type 2 diabetes has been compared . Regulation INSR TNF 10320052 612093 However , we found an approximately 2-fold increase in insulin stimulated tyrosine phosphorylation of the insulin receptor in the muscle and adipose tissue of TNF-alpha knockout mice , suggesting that [insulin receptor] signalling is an important *target* for . Regulation INSR TNF 17227768 1703824 We tested whether mitogenic activated protein kinase kinase kinase kinase isoform 4 ( MAP4K4 ) causes the induced negative *regulation* of extracellular signal regulated kinase-1/2 ( ERK-1/2 ) , c-Jun NH2-terminal kinase (JNK) , and the [insulin receptor substrate-1 (IRS-1)] on the insulin signaling pathway governing glucose metabolism . Regulation INSR TNF 17962866 1815164 *affects* [insulin receptor] substrate phosphorylation , resulting in decreased glucose uptake and compensatory hyperinsulinemia . Regulation INSR TNF 23660953 2805472 N-terminal kinase (JNK) signaling *plays* a central role in serine phosphorylation of [insulin receptor substrate-1 (IRS-1)] . Regulation INTS2 PLAU 14688127 1190431 To determine the role of [in T2] immune *responses* , wild-type ( WT ) and uPA ( -/- ) mice were primed and challenged with schistosomal egg antigen (SEA) . Regulation IRAK1 TLR7 18438411 1915429 Thus , IRAK2 is critical in late-phase *responses* , and [IRAK1] and IRAK2 are essential for the initial responses to TLR stimulation . Regulation IRAK1 TLR7 19166926 2038477 Phosphorylation of [IRAK-1] by IRAK-4 in *response* to activation may then release IRAK-1 from the inhibitory constraint exerted by its C-terminal domain . Regulation IRAK1 TLR7 21573018 2430139 Using phospho-specific antibodies and luciferase reporter assays , we further demonstrate that H. pylori induces [IRAK-1] and I?B phosphorylation in a *dependent* manner , and this was required for activation of transcription factor NF-?B . Regulation IRAK2 TLR7 18438411 1915439 Thus , IRAK2 is critical in late-phase *responses* , and IRAK1 and [IRAK2] are essential for the initial responses to TLR stimulation . Regulation IRAK2 TLR7 21606490 2450248 Collectively , these data demonstrate for the first time an essential *role* for [IRAK-2] in primary human cells for both transcriptional and post-transcriptional responses . Regulation IRAK4 IL1B 17321804 1740863 PC12 cells express [IL-1 receptor] type I and *response* to stimulation . Regulation IRAK4 TNF 10643716 660983 In *response* to stimulation , messenger RNA ( mRNA ) levels for the [IL-1 receptor I (IL-1RI)] , IL-1RII , TNF receptor II (TNFR II) , and IL-6 receptor as well as the level of proinflammatory cytokines , such as IL-1alpha , IL-1beta , lymphotoxin beta , TNFalpha , and IL-6 , also increased . Regulation IRF1 IL1B 16140971 1451009 We found that *regulated* [IRF-1] gene expression through stimulation of p38 mitogen activated protein kinase (MAPK) , which mediated signal transducer and activator of transcription 1 ( Stat1 ) serine phosphorylation and Stat1 nuclear translocation to activate the IRF-1 promoter . Regulation IRF1 IL1B 19843519 2170101 Histone deacetylase-1 is enriched at the platelet derived growth factor-D promoter in *response* to and forms a cytokine-inducible gene silencing complex with NF-kappab p65 and [interferon regulatory factor-1] . Regulation IRF1 IL1B 9973374 596011 We now report that levels of [IRF-1] and pIgR mRNA are coordinately *regulated* in HT-29 cells by TNF-alpha , IFN-gamma , and . Regulation IRF1 STAT4 10358173 618918 The *participation* of in the regulation of [IRF-1] was demonstrated in two ways . Regulation IRF1 TNF 10404391 629262 In the present study , we used FRTL-5 rat thyroid cells to examine the *effects* of IFN gamma and on gene expression of transcription factor [interferon regulatory factor-1 (IRF-1)] , which is involved in mediating the effects of these cytokines in a number of cell types . Regulation IRF1 TNF 18678606 1973292 *Regulation* of STAT pathways and [IRF1] during human dendritic cell maturation by and PGE2 . Regulation IRF1 TNF 9758167 535983 This transcriptional *regulation* of [IRF-1] gene by IFN-gamma and was confirmed at the mRNA level . Regulation IRF1 TNF 9973374 596009 We now report that levels of [IRF-1] and pIgR mRNA are coordinately *regulated* in HT-29 cells by , IFN-gamma , and IL-1beta . Regulation IRF3 CD14 22901688 2775128 Given that the ability of LPS to activate [IRF3] downstream of TLR4 depends on internalisation of the TLR4 complex and *involves* , we examined TLR4 endocytosis . Regulation IRF3 TLR7 22473004 2589117 NLRC5 ablation reduces MHC class I expression , and enhances IKK and [IRF3] phosphorylation in *response* to stimulation or viral infection . Regulation IRF4 FOXO1 21356515 2394807 Fasting induces [IRF4] in an insulin- and *dependent* manner . Regulation IRF4 TLR7 16243976 1476864 Here , we demonstrate that [IRF-4] negatively regulates the production of proinflammatory cytokines by macrophages in *response* to stimulation . Regulation IRF5 TLR7 24223576 2865176 The IRF5 exon 1B promoter has been characterized , and the *responses* of each [IRF5] promoter to stimulation have been determined . Regulation IRF8 CAPN8 20679491 2317417 Consistent with this , [ICSBP] decreases beta-catenin protein and activity in a Gas2- and *dependent* manner . Regulation IRF8 FAS 21487040 2417733 Consequently , restoration of [IRF8] expression suppressed CML development in vivo at least partially through a *dependent* mechanism . Regulation IRS1 EPHB2 10669726 665958 Finally , IGF mediated degradation of [IRS-1] was blocked by inhibition of phosphatidylinositol 3'-kinase activity but was not *affected* by inhibition of , suggesting that this may represent a direct negative-feedback mechanism resulting from downstream IRS-1 signaling . Regulation IRS1 FOXO1 22326951 2560651 Furthermore , we found that *dependent* downregulation of [IRS1] resulted in blunted Akt signaling and insulin resistance . Regulation IRS1 TNF 11287630 800302 The *effect* of on insulin promoted tyrosine phosphorylation of [IRS-1] was blocked by inhibition of PI 3-kinase and the PTEN tumor suppressor , which dephosphorylates the lipids that mediate PI 3-kinase functions , whereas constitutively active Akt impaired insulin promoted IRS-1 tyrosine phosphorylation . Regulation IRS1 TNF 11717189 881906 Moreover , had no *effect* on the activation of [IRS-1] induced by IL-4 . Regulation IRS1 TNF 12351658 1018870 In this study , using phosphospecific antibodies against rat IRS-1 phosphorylated at Ser ( 307 ) ( equivalent to Ser ( 312 ) in human IRS-1 ) , we observed serine phosphorylation of [IRS-1] in *response* to or calyculin A treatment that paralleled surrogate markers for IKK activation . Regulation IRS1 TNF 12714600 1100549 Taken together , these data suggest that serine phosphorylation of [IRS-1] in *response* to is mediated , in part , by JNK and IKK . Regulation IRS1 TNF 12887130 1116903 had no *effect* on either [IRS-1] phosphorylation or ERK in VSMC . Regulation IRS1 TNF 15721320 1374505 Here , we identify the death domain of TNF-R55 as responsible for the inhibitory *effects* of on tyrosine phosphorylation of [IRS-1] , implicating ceramide generated by A-SMase as a downstream mediator of inhibition of IR signaling . Regulation IRS1 TNF 16307448 1502934 In this process , did not *affect* IGF-1 mediated phosphorylation of [IRS-1] , IRS-2 , Akt , or Erks . Regulation IRS1 TNF 7559552 323944 *effect* on [IRS-1] in Fao hepatoma cells was not associated with a significant reduction in insulin receptor tyrosine kinase activity as measured in vitro but impaired the association of IRS-1 with phosphatidylinositol 3-kinase , localizing TNF impact to IRS-1 . Regulation IRS1 TNF 7559552 323945 TNF did not increase protein-tyrosine phosphatase activity and protein-tyrosine phosphatase inhibition by vanadate did not change *effect* on [IRS-1] tyrosine phosphorylation , suggesting that protein-tyrosine phosphatases are not involved in this TNF effect . Regulation IRS1 TNF 7559552 323947 *effect* on [IRS-1] tyrosine phosphorylation was not abolished by inhibiting protein kinase C using staurosporine , while inactivation of Ser/Thr phosphatases by calyculin A and okadaic acid mimicked it . Regulation IRS2 EPHB2 11228049 764000 PD98059 inhibited activation of and LY294002 repressed activation of Akt in response to IGF-I , but did not *affect* tyrosine phosphorylation of the IGF-IR , IRS-1 , [IRS-2] , or Shc . Regulation IRS2 FOXO1 17279346 1733261 Taken together , and SREBP-1c reciprocally *regulate* [IRS-2] expression and insulin sensitivity in the liver . Regulation IRS4 EGF 3048247 97188 [pp160] is not phosphorylated on tyrosine in *response* to platelet derived growth factor or . Regulation IRS4 IGF1 12639902 1068752 In human skeletal muscle cells , both IRS-1 and IRS-2 are rapidly phosphorylated on tyrosine in response to insulin , whereas essentially no tyrosine phosphorylation of [IRS-4] was observed in *response* to both insulin and . Regulation IRS4 IL4 7492780 332457 Enhanced tyrosine phosphorylation of [IRS-1/4PS] was observed in *response* to , but not IL-13 treatment of L cells transfected with the IL-2R gamma chain . Regulation IRS4 IL9 11788580 916892 Overexpression of IRS-1 and IRS-2 , but not [IRS-4] , induced proliferation of 32D ( IR ) cells in *response* to . Regulation IRS4 INS 12639902 1068753 In human skeletal muscle cells , both IRS-1 and IRS-2 are rapidly phosphorylated on tyrosine in response to insulin , whereas essentially no tyrosine phosphorylation of [IRS-4] was observed in *response* to both and IGF-I . Regulation IRS4 INS 1321133 190195 Zn2+ at 100 microM , Ni2+ at 1 mM , and Co2+ at 1 or 5 mM increased *dependent* phosphorylation of [pp160] at least 5-fold and autophosphorylation 2-fold . Regulation IRS4 INS 1321133 190197 Vanadate ( 1 mM ) and molybdate ( 100 microM ) increased *dependent* phosphorylation of [pp160] by 3-fold when tested separately and 7-fold in combination . Regulation IRS4 INS 1374400 186298 These results demonstrate that [pp160] is expressed in 3T3-L1 adipocytes during the time when insulin receptors are expressed in large numbers and that the maintenance of pp160 concentrations in adipocytes can be *regulated* by , Mix , and Dex . Regulation IRS4 PIK3CA 16933034 1646435 These results suggest that Ins and Ang II modulate [IRS-4] tyr-phosphorylation in a *dependent* manner . Regulation IRS4 PIK3R1 16933034 1646436 These results suggest that Ins and Ang II modulate [IRS-4] tyr-phosphorylation in a *dependent* manner . Regulation ITCH TP63 16908849 1608408 The E3 ubiquitin ligase [Itch] *controls* the protein stability of . Regulation ITCH TP63 16908849 1608411 Itch and p63 are coexpressed in the epidermis and in primary keratinocytes where [Itch] *controls* the protein steady-state level . Regulation ITGA2 C1QTNF1 16195328 1507787 had no *effects* on [alpha(2)beta(1) integrin] I-domain binding to collagen . Regulation ITGA2 TNF 16079290 1442669 Collectively , these results demonstrate an essential role for MMPs and [alpha2beta1 integrin] in the invasive *response* of 31EG4-2A4 cells to . Regulation ITGA2B F2R 10624968 658497 Aprotinin at 50 to 200 kallikrein inhibiting units/mL decreased the expression of activated [GP IIb-IIIa] complex in *response* to adenosine diphosphate or activator peptide 6 in a dose dependent manner in both citrated and heparinized whole blood experiments . Regulation ITGA2B F2R 23340049 2769788 The vasodilator stimulated phosphoprotein ( VASP ) phosphorylation assay , multiple electrode aggregometry (MEA) with adenosine diphosphate ( ADP ) , and surface expressions of P-selectin and activated [glycoprotein (GP) IIb/IIIa] in *response* to ADP and activating peptide ( TRAP ) -6 were assessed in 71 obese and 245 nonobese patients . Regulation ITGA4 ITGAL 11485925 844920 These results indicate that endothelial/lymphocyte adhesion cascades involving [VCAM-1/alpha(4)beta(1) integrin] , PNAd/L-selectin , and *control* the migration of lymphocytes into inflamed lacrimal gland . Regulation ITGA4 JAG1 7527450 280736 We investigated the effects of mAbs against VCAM-1 and [VLA-4] on cardiac allograft survival and humoral *response* to soluble . Regulation ITGA4 SELL 11504840 847895 These findings show that alpha4beta7 integrin and may *play* an important role in the lymphocyte homing of gastrointestinal low-grade MALT lymphoma and in the loss of [alpha4beta7 integrin] expression throughout the course of high-grade progression . Regulation ITGA5 EPHB2 20558745 2302510 rHSP90alpha induced the activities of , PI3K/Akt , and NF-kappaB p65 , but only NF-kappaB activation was *involved* in HSP90alpha induced [integrin alpha(V)] expression . Regulation ITGA5 SPHK1 20522645 2284189 Tumor necrosis factor induced neutrophil adhesion occurs via *dependent* activation of endothelial { [alpha}5{beta}1 integrin] . Regulation ITGA9 ADAM12 16061220 1453995 We demonstrated that phosphoinositide-3-kinase appears to be central in regulating [alpha9beta1 integrin] cell spreading activity in *response* to . Regulation ITGAE MMP7 19893044 2171468 Thus , to assess *effects* on [CD103-E-cadherin] interactions in lung injury , wild-type , CD103 ( -/- ) , and Mmp7 ( -/- ) mice , in which E-cadherin is n't cleaved in the lung , were treated with bleomycin or bleomycin with nFMLP to reverse the defect in acute neutrophil influx seen in Mmp7 ( -/- ) mice . Regulation ITGAL CA5A 17885011 1797390 The *effects* of on circulating CD40L , ICAM-1 , and MCP-1 , and monocyte surface expression of CD40 , [LFA-1] , and VLA-4 were greater than those of gin ( all P < 0.05 ) . Regulation ITGAL CBL 12697763 1100095 Thus , *plays* a negative role in Crk-L-C3G mediated Rap1 and [LFA-1] activation in T cells . Regulation ITGAL CCL2 11779737 900105 In *response* to plus E. coli LPS , we observed additional engagement of [CD11a] and CD106 for enhanced alveolar monocyte transmigration . Regulation ITGAL CD2 2574829 123420 We postulate that and CD3 can differentially *regulate* the affinity of [LFA-1] for its ligands by modulating its molecular conformation through PKC dependent mechanisms . Regulation ITGAL CD226 10591186 572560 These results indicate that is *involved* in the [LFA-1] mediated intracellular signals . Regulation ITGAL CD226 14676297 1178917 These results suggest that is *involved* in [LFA-1] mediated costimulatory signals for triggering naive T cell differentiation and proliferation . Regulation ITGAL CD4 10564550 567280 Blocking antibody to CD40 and CD154 ( CD40 ligand ) decreased the ability of monocytes to aid in T-cell survival , whereas , blocking [LFA-1/I-CAM-1] , Fas ligand and the histocompatibility complex class II interaction did not *affect* the influence of monocytes on T-cell survival . Regulation ITGAL CD40 10072527 594505 Surprisingly , up-regulation of Fas , CD23 , and ICAM-1 was partially independent , and up-regulation of [LFA-1] was completely *independent* , of induced NF-kappaB activation . Regulation ITGAL CD40 8566008 340579 In addition , the CD40 induced augmentation of processing is not attributable to the *effect* of ligation on the cell surface expression of B7 , [LFA-1] or CD23 . Regulation ITGAL CD99 9278313 450944 ( MIC2 ) *regulates* the [LFA-1/ICAM-1] mediated adhesion of lymphocytes , and its gene encodes both positive and negative regulators of cellular adhesion . Regulation ITGAL CSF2 3042045 95717 To assess the possible in vivo significance of these observations we studied the *effect* of on CD11b , [CD11a] ( LFA-1 ) , and CD11c ( gp 150 , 95 ) expression on granulocytes from nine adult patients with sarcoma who were receiving GM-CSF as part of a phase I trial . Regulation ITGAL FYN 15955842 1434502 Our observations indicate that chemoattractant receptor engagement induces Fyn dependent PI 3K activation in association with LFA-1 and suggests that is necessary to initiate and/or to *regulate* chemoattractant mediated [LFA-1] activation to promote directional migration . Regulation ITGAL IFNB1 15081256 1234104 We assessed possible *effects* of on the gene expression of the leukocyte adhesion molecules VLA-4 and [LFA-1] during the first year of treatment of 50 patients with relapsing remitting MS who showed differential clinical responses . Regulation ITGAL IFNG 2475518 116892 *Effects* of and tumor necrosis factor-alpha (TNF-alpha) on the expression of [LFA-1] in the moderate phenotype of leukocyte adhesion deficiency (LAD) . Regulation ITGAL IL4 7913345 262084 nevertheless did not *affect* the expression of [CD18/CD11a] and VLA-4 on the NK cell surface , as assessed by flow cytometry . Regulation ITGAL IL7 9420139 472429 A new *role* for in the induction of [LFA-1] and VLA-4 adhesion molecules in Phorbol 12myristate 13acetate activated CD4+ CD23+ T-cell subset . Regulation ITGAL ITGA4 11485925 844922 These results indicate that endothelial/lymphocyte adhesion cascades involving , PNAd/L-selectin , and [LFA-1] *control* the migration of lymphocytes into inflamed lacrimal gland . Regulation ITGAL ITGB1 11485925 844923 These results indicate that endothelial/lymphocyte adhesion cascades involving , PNAd/L-selectin , and [LFA-1] *control* the migration of lymphocytes into inflamed lacrimal gland . Regulation ITGAL ITGB2 1684295 173151 Cell-surface expression of human had no apparent *effect* on the level of endogenous murine [CD11a/CD18] expression . Regulation ITGAL LCK 12115650 964246 Thus , is *involved* in regulating [CD11a/CD18-integrins] in T cells . Regulation ITGAL LTF 10483875 643907 Regulatory *effects* of and lipopolysaccharide on [LFA-1] expression on human peripheral blood mononuclear cells . Regulation ITGAL MAP4K1 23682030 2785488 Gim me a brake : *regulates* [LFA-1] and neutrophil traction . Regulation ITGAL MRAS 17538012 1773204 Finally , we demonstrated that and RA-GEF-2 were indeed *involved* in TNF-alpha stimulated and Rap1 mediated [LFA-1] activation in splenocytes by using mice deficient in RA-GEF-2 . Regulation ITGAL MUC1 22983177 2706284 The objectives of this study were to determine if could *affect* the hematologic response to lipopolysaccharide (LPS) , the interleukin-1ß (IL-1ß) production , leukocyte migration , and blood leukocyte expression of [CD11a/CD18] . Regulation ITGAL MYC 11009078 735856 Since Myc overexpression has been associated with reduced expression of beta1 and beta2 integrins , we have investigated the *role* of on [CD11a] and CD11c transcription . Regulation ITGAL NFKB1 10072527 594506 Surprisingly , up-regulation of Fas , CD23 , and ICAM-1 was partially independent , and up-regulation of [LFA-1] was completely *independent* , of CD40 induced activation . Regulation ITGAL PARP1 11781564 891120 Here we show that this microglial migration is strongly controlled in living brain tissue by expression of the integrin [CD11a] , *regulated* by the nuclear enzyme ( PARP-1 ) through the formation of a nuclear PARP-NF-kappaB-protein complex . Regulation ITGAL PI3 10688643 670061 H-Ras and Rac activated [LFA-1] in a *dependent* manner , whereas Rho and R-Ras had little effect . Regulation ITGAL PXN 22274710 2520566 Central *role* of phosphorylation in regulation of [LFA-1] integrins activity and lymphocyte migration . Regulation ITGAL RAPGEF2 17538012 1773203 Finally , we demonstrated that M-Ras and were indeed *involved* in TNF-alpha stimulated and Rap1 mediated [LFA-1] activation in splenocytes by using mice deficient in RA-GEF-2 . Regulation ITGAL RELA 10072527 594507 Surprisingly , up-regulation of Fas , CD23 , and ICAM-1 was partially independent , and up-regulation of [LFA-1] was completely *independent* , of CD40 induced activation . Regulation ITGAL RFX1 21192791 2360647 *regulates* CD70 and [CD11a] expression in lupus T cells by recruiting the histone methyltransferase SUV39H1 . Regulation ITGAL RUNX1 12855590 1149918 and C/EBP factors *regulate* [CD11a] integrin expression in myeloid cells through overlapping regulatory elements . Regulation ITGAL RUNX2 12855590 1149919 and C/EBP factors *regulate* [CD11a] integrin expression in myeloid cells through overlapping regulatory elements . Regulation ITGAL RUNX3 12855590 1149920 and C/EBP factors *regulate* [CD11a] integrin expression in myeloid cells through overlapping regulatory elements . Regulation ITGAL RUNX3 16164020 1456209 *regulates* the activity of the [CD11a] and CD49d integrin gene promoters . Regulation ITGAL SLC25A3 9723775 529264 Results suggest that protein phosphatase 2A (PP2A) is not involved in these processes whereas negatively *regulate* [LFA-1] expression and tumour-cell binding of cisplatin treated macrophages . Regulation ITGAL SPN 17996943 1866780 These results indicate that triggering CD43 and the underlying signaling pathways enhance LFA-1 adhesiveness while also negatively *regulates* [LFA-1] induction via other receptors by dynamic interaction with either LFA-1 or CD147 . Regulation ITGAL SUV39H1 21192791 2360646 RFX1 *regulates* CD70 and [CD11a] expression in lupus T cells by recruiting the histone methyltransferase . Regulation ITGAL TGM4 22659657 2610848 To investigate the *effect* of on expression and DNA methylation status of [ITGAL] gene ( CD11a ) in CD4 ( + ) T cells from patients with systemic lupus erythematosus ( SLE ) . Regulation ITGAL TLN1 22075696 2517182 , an [LFA-1] *regulator* , localizes to the immune synapse ( IS ) with unknown roles in T cell activation . Regulation ITGAL TNF 21507295 2418531 To study the *effects* of on ICAM-1 and [LFA-1] expression in peripheral blood mononuclear cells ( PBMC ) of children with febrile seizures ( FS ) . Regulation ITGAL TNF 2161875 135843 did not *affect* the expression of [LFA1] , CD2 , CD4 , and CD8 , molecules that are associated with CTL-target interactions , on responder cells . Regulation ITGAL TNF 2475518 116891 *Effects* of interferon-gamma (IFN-gamma) and on the expression of [LFA-1] in the moderate phenotype of leukocyte adhesion deficiency (LAD) . Regulation ITGAL VCAM1 11485925 844921 These results indicate that endothelial/lymphocyte adhesion cascades involving integrin , PNAd/L-selectin , and [LFA-1] *control* the migration of lymphocytes into inflamed lacrimal gland . Regulation ITGAM ALOX5 15388786 1359156 *Effects* of prostaglandin D ( 2 ) and <5-lipoxygenase> products on the expression of CD203c and [CD11b] by basophils . Regulation ITGAM ALOX5 16159627 1455996 We studied the *effects* of <5-LO> products on Ca ( 2+ ) mobilization , migration , [CD 11b] expression , and degranulation of human basophils . Regulation ITGAM ALOX5 9274839 450611 Inhibition of <5-lipoxygenase> did not *affect* the expression of [CD11b] and CD18 during dialysis with either of the two membranes . Regulation ITGAM CD14 7519640 266153 These studies suggest that *affects* [CD11b/CD18] function by inducing the synthesis of a lipid such as IMF-1 , and that this lipid affects only the binding activity , not the phagocytosis promoting capacity of CD11b/CD18 . Regulation ITGAM HES2 16247329 1471564 The *effect* of on PMN surface expression of [CD11b] and L-selectin was measured by flow cytometry . Regulation ITGAM TLR7 23573259 2768124 CAD patients showed a significantly higher L-selectin , but not [CD11b] *response* to ligation than controls after single dose stimulations as well as significant differences in the hillslope and EC50 of the dose-response curves . Regulation ITGAM TNF 10843415 700072 The *effects* of human recombinant on neutrophil ( PMNL ) oxidative burst and on [CD11b/CD18] and CD14 expression after stimulation with pathogenic or nonpathogenic Neisseria meningitidis were studied using chemiluminescence and flow cytometry . Regulation ITGAM TNF 15352552 1292776 In vitro *regulation* of [Mac-1] expression on bovine polymorphonuclear leukocytes by endotoxin and at different stages of lactation . Regulation ITGAM TNF 15352552 1292777 In addition , we evaluated the *effect* of lipopolysaccharide (LPS) and on [CD11b] surface expression in PMN at different stages of lactation in a whole blood model . Regulation ITGAV EPHB2 16014375 1441432 Engagement of [alphavbeta3 integrin] triggered ERK1/2 phosphorylation , but the underlying molecular mechanism was surprisingly *independent* of the well known Shc/Ras/Raf-1 cascade , and of phosphorylated , so far the only recognized direct activator of ERK1/2 . Regulation ITGAV TNF 15273742 1296418 *regulates* epithelial expression of MMP-9 and [integrin alphavbeta6] during tumour promotion . Regulation ITGB1 ANGPT1 19916173 2166595 To evaluate the *effects* of on adhesion of gastric cancer cell line BGC-823 and expression of [integrin beta1] , CD44V6 , urokinase-type plasminogen activator ( uPA ) and matrix metalloproteinase-2 (MMP-2) . Regulation ITGB1 C1QTNF1 16195328 1507788 had no *effects* on [alpha(2)beta(1) integrin] I-domain binding to collagen . Regulation ITGB1 EPHB2 11251083 793895 In addition , we demonstrated that inhibition of extracellular matrix receptor , such as integrin beta1 subunit , leads to cell arrest in G1 , whereas EGF was found to up-regulated [integrin beta1] and fibronectin in a *dependent* manner . Regulation ITGB1 ITGAL 11485925 844924 These results indicate that endothelial/lymphocyte adhesion cascades involving [VCAM-1/alpha(4)beta(1) integrin] , PNAd/L-selectin , and *control* the migration of lymphocytes into inflamed lacrimal gland . Regulation ITGB1 JAG1 7527450 280737 We investigated the effects of mAbs against VCAM-1 and [VLA-4] on cardiac allograft survival and humoral *response* to soluble . Regulation ITGB1 MAP2K6 11251083 793901 In addition , we demonstrated that inhibition of extracellular matrix receptor , such as integrin beta1 subunit , leads to cell arrest in G1 , whereas EGF was found to up-regulated [integrin beta1] and fibronectin in a *dependent* manner . Regulation ITGB1 SPHK1 20522645 2284190 Tumor necrosis factor induced neutrophil adhesion occurs via *dependent* activation of endothelial { [alpha}5{beta}1 integrin] . Regulation ITGB1 TNF 16079290 1442670 Collectively , these results demonstrate an essential role for MMPs and [alpha2beta1 integrin] in the invasive *response* of 31EG4-2A4 cells to . Regulation ITGB2 ALOX5 9274839 450612 Inhibition of <5-lipoxygenase> did not *affect* the expression of CD11b and [CD18] during dialysis with either of the two membranes . Regulation ITGB2 ANGPT2 19728062 2175865 Association of Ang-2 with [integrin beta 2] *controls* dependent upregulation of human peripheral blood monocyte fibrinolysis . Regulation ITGB2 APOB 7531948 291971 In vitro *effects* of oxidized low density on [CD11b/CD18] and L-selectin presentation on neutrophils and monocytes with relevance for the in vivo situation . Regulation ITGB2 ATG10 15919513 1413363 Furthermore , the *effects* of on [CD11/CD18] were dependent on the dosage and type of ATG . Regulation ITGB2 ATG12 15919513 1413366 Furthermore , the *effects* of on [CD11/CD18] were dependent on the dosage and type of ATG . Regulation ITGB2 ATG13 15919513 1413365 Furthermore , the *effects* of on [CD11/CD18] were dependent on the dosage and type of ATG . Regulation ITGB2 ATG14 15919513 1413362 Furthermore , the *effects* of on [CD11/CD18] were dependent on the dosage and type of ATG . Regulation ITGB2 ATG3 15919513 1413364 Furthermore , the *effects* of on [CD11/CD18] were dependent on the dosage and type of ATG . Regulation ITGB2 ATG5 15919513 1413367 Furthermore , the *effects* of on [CD11/CD18] were dependent on the dosage and type of ATG . Regulation ITGB2 ATG7 15919513 1413361 Furthermore , the *effects* of on [CD11/CD18] were dependent on the dosage and type of ATG . Regulation ITGB2 C5 15454120 1301147 Eosinophils showed a significant increase in [Mac-1] expression after activation with fMLP or with rh GM-CSF plus ah CD23 mAbs ( p < 0.05 , each comparison ) and a remarkable chemotactic *response* to both or rh IL-5 ( p < 0.001 , each comparison ) . Regulation ITGB2 CA2 1361124 206164 Cross linking of [CD18] also increased cytosolic free [ Ca2+ ] i in a subset of approx. 15-20 % of resting T lymphocytes , in a *response* that was completely abrogated during T-cell mitogenic activation with lectins or alloreactive antigen . Regulation ITGB2 CA2 1702813 151312 Together these data suggest a *dependent* conformational change in [Mac-1] , which allows distinction of the roles of Mac-1 in phagocytosis and adhesion . Regulation ITGB2 CA2 7510713 249993 We conclude that is *involved* in avidity regulation of [LFA-1] by clustering of LFA-1 molecules at the cell surface , whereas Mg2+ is important in regulation of the affinity of LFA-1 for its ligands . Regulation ITGB2 CCL1 21976223 2512771 Importantly , directly *regulated* the expression of [CD18] and CD49b and hence influenced the adhesion capacity of human macrophages . Regulation ITGB2 CCR7 22117043 2541380 Hence , 2 independent ADAP/SKAP55 modules are essential components of the signaling machinery that regulates affinity and avidity of [LFA-1] in *response* to . Regulation ITGB2 CD14 7519640 266154 These studies suggest that *affects* [CD11b/CD18] function by inducing the synthesis of a lipid such as IMF-1 , and that this lipid affects only the binding activity , not the phagocytosis promoting capacity of CD11b/CD18 . Regulation ITGB2 CD2 3093887 63418 and ( 2 ) suggest that and LFA-3 are *involved* in one pathway and [LFA-1] in another . Regulation ITGB2 CD4 10564550 567281 Blocking antibody to CD40 and CD154 ( CD40 ligand ) decreased the ability of monocytes to aid in T-cell survival , whereas , blocking [LFA-1/I-CAM-1] , Fas ligand and the histocompatibility complex class II interaction did not *affect* the influence of monocytes on T-cell survival . Regulation ITGB2 CD4 15259014 1272569 By using specific inhibitors , raft integrity and CD4 association with GM3 were found necessary for observing the *dependent* inhibition of [LFA-1] mediated adhesion . Regulation ITGB2 CD4 21850260 2468770 The data show that HIV-1 gp120 was sufficient to trigger [LFA-1] activation in fully quiescent naïve CD4 T cells in a *dependent* manner , and these CD4 T cells became more susceptible to killing by LtxA , a bacterial leukotoxin that preferentially targets leukocytes expressing high levels of the active LFA-1 . Regulation ITGB2 CD4 8207199 261370 [LFA-1] mediated antigen independent T cell adhesion is *regulated* by and p56lck tyrosine kinase . Regulation ITGB2 CD4 8943387 400013 Phosphatidylinositol 3-kinase participates in p56 ( lck ) *dependent* down-regulation of [LFA-1] mediated T cell adhesion . Regulation ITGB2 CD58 3093887 63419 and ( 2 ) suggest that CD2 and are *involved* in one pathway and [LFA-1] in another . Regulation ITGB2 CPB1 8105757 231414 In this study , the *effects* of on the expression of neutrophil CD11b and [CD18] ( the components of the Mac-1 adhesion molecule ) were examined ; Regulation ITGB2 CPB2 8105757 231415 In this study , the *effects* of on the expression of neutrophil CD11b and [CD18] ( the components of the Mac-1 adhesion molecule ) were examined ; Regulation ITGB2 CSDE1 12485937 1032972 We hypothesize that a -- an enhanceosome -- that includes GABP , other transcription factors , and coactivators , dynamically *regulates* [CD18] expression in myeloid cells . Regulation ITGB2 CTSZ 18194276 1895313 On the other hand , co-localization of cathepsin X and LFA-1 supports the *role* of in regulating [LFA-1] activity , which enhances lymphocyte proliferation . Regulation ITGB2 CYTH1 10835351 697836 Thus , is *involved* in the activation of [LFA-1] , most probably through direct interaction with the integrin , and induces cell spreading by its ARF-GEF activity . Regulation ITGB2 DYNLRB1 11386619 821715 Up-regulation of PMN [Mac-1] in *response* to occurred independently of membrane bound CD14 (mCD14) . Regulation ITGB2 EDN1 9373765 464805 In addition , we investigated the *effects* of on expression of the leucocyte adhesion molecules [CD11b/CD18] and L-selectin on monocytes and neutrophils . Regulation ITGB2 EEF1A2 19424968 2090185 This inhibition was paralleled by a *dependent* inhibition of [LFA-1] mediated adhesion and a reduction of NK-cell polarization . Regulation ITGB2 EPAS1 10483875 643908 The aim of this study was to investigate *effects* of with regard to [LFA-1] expression on unstimulated and lipopolysaccharide (LPS) activated human peripheral blood mononuclear cells ( PBMC ) . Regulation ITGB2 EPAS1 10483875 643909 In about one third of cases no significant *effects* of LPS or on [LFA-1] expression were seen . Regulation ITGB2 FGB 22342352 2576524 Importantly , we propose that as [Mac-1] activation was not *affected* by the binding of , activated neutrophils can further maintain their ability to marginate , roll and adhere to the endothelial walls . Regulation ITGB2 FN1 7594504 334779 Incubation of fluid-phase PMN with anti-VLA-5 ( alpha 5/beta 1 ) and anti-VLA-6 ( alpha 6/beta 1 ) mAbs blocked the *effect* of and laminin on CD16 and [CD11b/CD18] expression . Regulation ITGB2 FN1 7594504 334788 Depletion of intracellular Ca2+ abrogated the *effects* of and laminin on CD16 and [CD11b/CD18] expression , while restoration of intracellular Ca2+ restored the ability of fibronectin and laminin to increase CD16 and CD11b/CD18 expression . Regulation ITGB2 HNRNPD 12485937 1032973 We hypothesize that a -- an enhanceosome -- that includes GABP , other transcription factors , and coactivators , dynamically *regulates* [CD18] expression in myeloid cells . Regulation ITGB2 ICAM1 11466362 839934 Binding of a novel CD18 activation epitope mAb to [LFA-1] in *response* to soluble binding was also blocked by inhibitory and was enhanced by activating IDAS mutations . Regulation ITGB2 ICAM1 8829772 371502 These findings suggest that production is induced by endotoxins and cytokines produced in excess by inflammatory reactions and that endotoxins and cytokines are *involved* in qualitative , but not quantitative changes in [LFA-1] ( CD11a/CD18 ) and Mac-1 ( CD11b/CD18 ) . Regulation ITGB2 ICAM1 9130650 426912 We have investigated the *role* of ligands ( and ICAM-3 ) in [LFA-1] activation by using ICAM blocking monoclonal antibodies and a fixation protocol for `` freezing '' LFA-1 on the surface of cells after prior exposure to ICAM-1 and ICAM-3 . Regulation ITGB2 ICAM3 9130650 426913 We have investigated the *role* of ligands ( ICAM-1 and ) in [LFA-1] activation by using ICAM blocking monoclonal antibodies and a fixation protocol for `` freezing '' LFA-1 on the surface of cells after prior exposure to ICAM-1 and ICAM-3 . Regulation ITGB2 IFNG 11896209 920865 Because IFN-gamma is an important cytokine during granulocytic ehrlichiosis and is known to activate leukocytes , we investigated the potential *role* of in [CD11b/CD18] up-regulation . Regulation ITGB2 IFNG 12508147 1038515 CD11b/c and [CD18] expression on circulating PMNLs was not *affected* by , nor was the chemotaxis of these cells . Regulation ITGB2 IFNG 1355014 195700 These results collectively suggest that expression of [LFA-1] and ICAM-1 is regulated differently and that and PMA *regulate* the expression through different mechanisms . Regulation ITGB2 IFNG 2476508 117011 In view of the importance of keratinocyte/lymphocyte interactions in the pathogenesis of cutaneous disease , we have examined the *effects* of in vivo on cutaneous expression of [LFA-1] and ICAM-1 . Regulation ITGB2 IL10 11230988 789440 The *effect* of on the expression of monocyte adhesion molecules ( [CD18] and CD62-L ) was studied by flow cytometry . Regulation ITGB2 IL1A 9698257 524885 and TNF-alpha differentially *regulate* CD4 and [Mac-1] expression in mouse microglia . Regulation ITGB2 IL1B 11702046 878816 The expression of [CD18] on neutrophils in vitro was not *affected* by either or hypothermia . Regulation ITGB2 IL1B 9197378 438557 In addition , pretreatment of infected monocytes with a TNF-alpha synthesis inhibitor , RP 55778 , or with MAbs directed against IL-1beta , confirmed the *role* of TNF-alpha and in the regulation of [CD18] , CD44 , and CD54 expression . Regulation ITGB2 IL4 7509842 249537 beta 2-Adrenoceptor stimulation was also found to potentiate the *effect* of on CD11b , CD11c , and [CD18] expression . Regulation ITGB2 IL4 7913345 262086 nevertheless did not *affect* the expression of [CD18/CD11a] and VLA-4 on the NK cell surface , as assessed by flow cytometry . Regulation ITGB2 IL5 15454120 1301148 Eosinophils showed a significant increase in [Mac-1] expression after activation with fMLP or with rh GM-CSF plus ah CD23 mAbs ( p < 0.05 , each comparison ) and a remarkable chemotactic *response* to both C5a or rh ( p < 0.001 , each comparison ) . Regulation ITGB2 IL8 9024987 405816 Thus the suppression of [CD11b/CD18] expression by tepoxalin may *involve* . Regulation ITGB2 ILK 9618871 510344 Thus , the [CD11b/CD18] heterodimer is apparently up regulated in *response* to the injected and plays a major role in the adherence of activated heterophils . Regulation ITGB2 ITGA1 16301335 1485105 Specific and beta chain phosphorylations *regulate* [LFA-1] activation through affinity dependent and -independent mechanisms . Regulation ITGB2 ITGA10 16301335 1485106 Specific and beta chain phosphorylations *regulate* [LFA-1] activation through affinity dependent and -independent mechanisms . Regulation ITGB2 ITGA11 16301335 1485107 Specific and beta chain phosphorylations *regulate* [LFA-1] activation through affinity dependent and -independent mechanisms . Regulation ITGB2 ITGA2 16301335 1485108 Specific and beta chain phosphorylations *regulate* [LFA-1] activation through affinity dependent and -independent mechanisms . Regulation ITGB2 ITGA3 16301335 1485109 Specific and beta chain phosphorylations *regulate* [LFA-1] activation through affinity dependent and -independent mechanisms . Regulation ITGB2 ITGA4 16301335 1485110 Specific and beta chain phosphorylations *regulate* [LFA-1] activation through affinity dependent and -independent mechanisms . Regulation ITGB2 ITGA5 16301335 1485111 Specific and beta chain phosphorylations *regulate* [LFA-1] activation through affinity dependent and -independent mechanisms . Regulation ITGB2 ITGA6 16301335 1485112 Specific and beta chain phosphorylations *regulate* [LFA-1] activation through affinity dependent and -independent mechanisms . Regulation ITGB2 ITGA7 16301335 1485113 Specific and beta chain phosphorylations *regulate* [LFA-1] activation through affinity dependent and -independent mechanisms . Regulation ITGB2 ITGA8 16301335 1485114 Specific and beta chain phosphorylations *regulate* [LFA-1] activation through affinity dependent and -independent mechanisms . Regulation ITGB2 ITGA9 16301335 1485115 Specific and beta chain phosphorylations *regulate* [LFA-1] activation through affinity dependent and -independent mechanisms . Regulation ITGB2 ITGAL 10639327 660471 Taken together , these data demonstrate that low affinity [LFA-1] binding to ICAM-3 *regulates* strong LFA-1/ICAM-1 mediated adhesion by driving into clusters to facilitate cell-cell interactions that take place in the immune system . Regulation ITGB2 ITGAL 10882733 722469 [CD11a/CD18] leukocyte restricted expression is *controlled* by the gene promoter , which confers tissue-specific expression to reporter genes in vitro and in vivo . Regulation ITGB2 ITGAL 11165259 782757 We show that CD98 cross linking persistently activates Rap1 GTPase in a *dependent* manner and induces [LFA-1/ICAM-1] mediated cell adhesion in lymphocytes . Regulation ITGB2 ITGAL 12147632 970084 [LFA-1] may enhance co-stimulation , and both and CD62L are *involved* in T cell trafficking . Regulation ITGB2 ITGAL 15544853 1355258 The mRNA expression levels following the anti-CD3 and anti-CD3+SOM treatment for 30 min was greater on the CD8+ T cells , and the [LFA-1] expression of the CD8+ T cells with anti-CD+SOM treatment was *affected* more severely than that of the CD4+ T cells . Regulation ITGB2 KLRAP1 17237371 1689822 Activating receptors *regulate* [LFA-1] mediated adhesion by NK cells . Regulation ITGB2 LCK 12115650 964247 Thus , is *involved* in regulating [CD11a/CD18-integrins] in T cells . Regulation ITGB2 LPA 7531948 291972 In vitro *effects* of oxidized low density on [CD11b/CD18] and L-selectin presentation on neutrophils and monocytes with relevance for the in vivo situation . Regulation ITGB2 MAPK1 10229812 611088 Furthermore , PMA induced activation of [LFA-1] on DA-ER cells overexpressing wild-type SHIP was dependent on protein kinase C but *independent* of activation , whereas cytokine induced activation was independent of protein kinase C and mitogen activated protein kinase activation but required phosphatidylinositol-3 kinase activation . Regulation ITGB2 MAPK1 11529937 853749 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Regulation ITGB2 MAPK10 10229812 611089 Furthermore , PMA induced activation of [LFA-1] on DA-ER cells overexpressing wild-type SHIP was dependent on protein kinase C but *independent* of activation , whereas cytokine induced activation was independent of protein kinase C and mitogen activated protein kinase activation but required phosphatidylinositol-3 kinase activation . Regulation ITGB2 MAPK10 11529937 853750 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Regulation ITGB2 MAPK11 10229812 611090 Furthermore , PMA induced activation of [LFA-1] on DA-ER cells overexpressing wild-type SHIP was dependent on protein kinase C but *independent* of activation , whereas cytokine induced activation was independent of protein kinase C and mitogen activated protein kinase activation but required phosphatidylinositol-3 kinase activation . Regulation ITGB2 MAPK11 11529937 853751 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Regulation ITGB2 MAPK12 10229812 611091 Furthermore , PMA induced activation of [LFA-1] on DA-ER cells overexpressing wild-type SHIP was dependent on protein kinase C but *independent* of activation , whereas cytokine induced activation was independent of protein kinase C and mitogen activated protein kinase activation but required phosphatidylinositol-3 kinase activation . Regulation ITGB2 MAPK12 11529937 853752 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Regulation ITGB2 MAPK13 10229812 611092 Furthermore , PMA induced activation of [LFA-1] on DA-ER cells overexpressing wild-type SHIP was dependent on protein kinase C but *independent* of activation , whereas cytokine induced activation was independent of protein kinase C and mitogen activated protein kinase activation but required phosphatidylinositol-3 kinase activation . Regulation ITGB2 MAPK13 11529937 853753 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Regulation ITGB2 MAPK14 10229812 611093 Furthermore , PMA induced activation of [LFA-1] on DA-ER cells overexpressing wild-type SHIP was dependent on protein kinase C but *independent* of activation , whereas cytokine induced activation was independent of protein kinase C and mitogen activated protein kinase activation but required phosphatidylinositol-3 kinase activation . Regulation ITGB2 MAPK14 11529937 853754 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Regulation ITGB2 MAPK15 10229812 611087 Furthermore , PMA induced activation of [LFA-1] on DA-ER cells overexpressing wild-type SHIP was dependent on protein kinase C but *independent* of activation , whereas cytokine induced activation was independent of protein kinase C and mitogen activated protein kinase activation but required phosphatidylinositol-3 kinase activation . Regulation ITGB2 MAPK15 11529937 853748 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Regulation ITGB2 MAPK3 10229812 611094 Furthermore , PMA induced activation of [LFA-1] on DA-ER cells overexpressing wild-type SHIP was dependent on protein kinase C but *independent* of activation , whereas cytokine induced activation was independent of protein kinase C and mitogen activated protein kinase activation but required phosphatidylinositol-3 kinase activation . Regulation ITGB2 MAPK3 11529937 853755 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Regulation ITGB2 MAPK4 10229812 611095 Furthermore , PMA induced activation of [LFA-1] on DA-ER cells overexpressing wild-type SHIP was dependent on protein kinase C but *independent* of activation , whereas cytokine induced activation was independent of protein kinase C and mitogen activated protein kinase activation but required phosphatidylinositol-3 kinase activation . Regulation ITGB2 MAPK4 11529937 853756 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Regulation ITGB2 MAPK6 10229812 611096 Furthermore , PMA induced activation of [LFA-1] on DA-ER cells overexpressing wild-type SHIP was dependent on protein kinase C but *independent* of activation , whereas cytokine induced activation was independent of protein kinase C and mitogen activated protein kinase activation but required phosphatidylinositol-3 kinase activation . Regulation ITGB2 MAPK6 11529937 853757 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Regulation ITGB2 MAPK7 10229812 611097 Furthermore , PMA induced activation of [LFA-1] on DA-ER cells overexpressing wild-type SHIP was dependent on protein kinase C but *independent* of activation , whereas cytokine induced activation was independent of protein kinase C and mitogen activated protein kinase activation but required phosphatidylinositol-3 kinase activation . Regulation ITGB2 MAPK7 11529937 853758 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Regulation ITGB2 MAPK8 10229812 611098 Furthermore , PMA induced activation of [LFA-1] on DA-ER cells overexpressing wild-type SHIP was dependent on protein kinase C but *independent* of activation , whereas cytokine induced activation was independent of protein kinase C and mitogen activated protein kinase activation but required phosphatidylinositol-3 kinase activation . Regulation ITGB2 MAPK8 11529937 853759 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Regulation ITGB2 MAPK9 10229812 611099 Furthermore , PMA induced activation of [LFA-1] on DA-ER cells overexpressing wild-type SHIP was dependent on protein kinase C but *independent* of activation , whereas cytokine induced activation was independent of protein kinase C and mitogen activated protein kinase activation but required phosphatidylinositol-3 kinase activation . Regulation ITGB2 MAPK9 11529937 853760 Taken together , these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 *dependent* up-regulation of [CD11b/CD18] but also by modulating the signalling pathways . Regulation ITGB2 MCOLN1 9188101 437104 The binding of recombinant secreted [LFA-1] to ICAM-1 is divalent cation *dependent* ( and Mn2+ promote binding ) and sensitive to inhibition by antibodies that block LFA-1 mediated cell adhesion , indicating that its conformation mimics that of LFA-1 on activated lymphocytes . Regulation ITGB2 MIF 23720662 2793184 This review will cover the mechanisms underlying these functions , including 's *effects* on [LFA1] integrin activity and signal transduction , and will discuss the structural similarities between MIF and the bona fide CXCR2 ligand CXCL8 while emphasizing the structural differences . Regulation ITGB2 MRE11A 12171996 974306 In T-lymphocytes the Ras-like small GTPase *plays* an essential role in stimulus induced inside-out activation of integrin [LFA-1] ( alpha ( L ) beta ( 2 ) ) and VLA-4 ( alpha ( 4 ) beta ( 1 ) ) . Regulation ITGB2 MUC1 22983177 2706285 The objectives of this study were to determine if could *affect* the hematologic response to lipopolysaccharide (LPS) , the interleukin-1ß (IL-1ß) production , leukocyte migration , and blood leukocyte expression of [CD11a/CD18] . Regulation ITGB2 NEU1 15330180 1287679 This study investigated whether *affects* [LFA-1] mRNA expression in spleen cells and whether somatostatin (SOM) and substance P ( SP ) treatment induce changes in the Neu mRNA expression level in spleen cells . Regulation ITGB2 PABPC1 12485937 1032974 We hypothesize that a -- an enhanceosome -- that includes GABP , other transcription factors , and coactivators , dynamically *regulates* [CD18] expression in myeloid cells . Regulation ITGB2 PAIP1 12485937 1032971 We hypothesize that a -- an enhanceosome -- that includes GABP , other transcription factors , and coactivators , dynamically *regulates* [CD18] expression in myeloid cells . Regulation ITGB2 PARP1 12171996 974304 In T-lymphocytes the Ras-like small GTPase *plays* an essential role in stimulus induced inside-out activation of integrin [LFA-1] ( alpha ( L ) beta ( 2 ) ) and VLA-4 ( alpha ( 4 ) beta ( 1 ) ) . Regulation ITGB2 PDGFB 19728062 2175866 Association of Ang-2 with [integrin beta 2] *controls* dependent upregulation of human peripheral blood monocyte fibrinolysis . Regulation ITGB2 PLA2G1B 8228253 235736 *Regulation* of [CD11b/CD18] expression in human neutrophils by . Regulation ITGB2 PLD1 19934331 2172258 Specifically , RhoA and were crucially *involved* in [LFA-1] affinity triggering by CXCL12 in all analyzed patients . Regulation ITGB2 PRKCZ 19086264 2003590 The objective of this study was to examine the *role* of in interleukin (IL)-8 mediated activation of [Mac-1] ( CD11b/CD18 ) in human neutrophils . Regulation ITGB2 PTPRC 8405045 232401 mediated *regulation* of [LFA1] function in human natural killer cells . Regulation ITGB2 PXN 20388733 2245290 Phosphorylation of at threonine 538 by PKCdelta *regulates* [LFA1] mediated adhesion of lymphoid cells . Regulation ITGB2 RAD50 12171996 974307 In T-lymphocytes the Ras-like small GTPase *plays* an essential role in stimulus induced inside-out activation of integrin [LFA-1] ( alpha ( L ) beta ( 2 ) ) and VLA-4 ( alpha ( 4 ) beta ( 1 ) ) . Regulation ITGB2 RHO 19136961 2025512 Unexpectedly , another family member , Cdc42 , negatively *regulated* [LFA-1] activation . Regulation ITGB2 RHOA 19934331 2172257 Specifically , and phospholipase D1 were crucially *involved* in [LFA-1] affinity triggering by CXCL12 in all analyzed patients . Regulation ITGB2 SELL 12147632 970083 [LFA-1] may enhance co-stimulation , and both LFA-1 and are *involved* in T cell trafficking . Regulation ITGB2 SELL 7543524 314320 Surface expression of [CD18] and an activation dependent epitope , as detected with mAb24 , also increased in *response* to cross linking . Regulation ITGB2 SYK 18550846 1952290 However , DeltaCD neutrophils rolling on P-selectin did not trigger *dependent* activation of [LFA-1] to slow rolling on ICAM-1 . Regulation ITGB2 SYNCRIP 12485937 1032970 We hypothesize that a -- an enhanceosome -- that includes GABP , other transcription factors , and coactivators , dynamically *regulates* [CD18] expression in myeloid cells . Regulation ITGB2 TERF2 12171996 974301 In T-lymphocytes the Ras-like small GTPase *plays* an essential role in stimulus induced inside-out activation of integrin [LFA-1] ( alpha ( L ) beta ( 2 ) ) and VLA-4 ( alpha ( 4 ) beta ( 1 ) ) . Regulation ITGB2 TERF2IP 12171996 974303 In T-lymphocytes the Ras-like small GTPase *plays* an essential role in stimulus induced inside-out activation of integrin [LFA-1] ( alpha ( L ) beta ( 2 ) ) and VLA-4 ( alpha ( 4 ) beta ( 1 ) ) . Regulation ITGB2 THBS1 12225809 987854 We therefore propose that may *regulate* [LFA-1/ICAM-1] mediated cell adhesion of monocytes/macrophages by either the inhibitory effect through CD47 or the promoting effect through CD36 depending on which domain/fragment is functional in a given biological setting . Regulation ITGB2 TNF 10843415 700073 The *effects* of human recombinant on neutrophil ( PMNL ) oxidative burst and on [CD11b/CD18] and CD14 expression after stimulation with pathogenic or nonpathogenic Neisseria meningitidis were studied using chemiluminescence and flow cytometry . Regulation ITGB2 TNF 1347308 179230 The current studies also demonstrated that when surface bound IgG immune complexes were treated with fresh rat serum , the increment in O2- and TNF alpha generated by alveolar macrophages was suppressed by anti-CD18 , but not by anti-CD11b , suggesting a heretofore unrecognized role for [CD18] in the O2- and *responses* of alveolar macrophages . Regulation ITGB2 TNF 18164590 1855580 *regulates* [Mac-1] up-regulation through signalling pathways , involving various kinases , but not JNK 1/2 . Regulation ITGB2 TNF 9197378 438556 In addition , pretreatment of infected monocytes with a TNF-alpha synthesis inhibitor , RP 55778 , or with MAbs directed against IL-1beta , confirmed the *role* of and IL-1beta in the regulation of [CD18] , CD44 , and CD54 expression . Regulation ITGB2 TNF 9698257 524884 IL-1-alpha and differentially *regulate* CD4 and [Mac-1] expression in mouse microglia . Regulation ITGB2 TOC 10380896 623957 We evaluated the *effects* of on surface expression of [CD11b/CD18] on polymorphonuclear leukocytes ( PMN ) stimulated with N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) and oxidized low-density lipoprotein ( oxLDL ) . Regulation ITGB2 XRCC5 12171996 974302 In T-lymphocytes the Ras-like small GTPase *plays* an essential role in stimulus induced inside-out activation of integrin [LFA-1] ( alpha ( L ) beta ( 2 ) ) and VLA-4 ( alpha ( 4 ) beta ( 1 ) ) . Regulation ITGB2 XRCC6 12171996 974305 In T-lymphocytes the Ras-like small GTPase *plays* an essential role in stimulus induced inside-out activation of integrin [LFA-1] ( alpha ( L ) beta ( 2 ) ) and VLA-4 ( alpha ( 4 ) beta ( 1 ) ) . Regulation ITGB3 EPHB2 16014375 1441433 Engagement of [alphavbeta3 integrin] triggered ERK1/2 phosphorylation , but the underlying molecular mechanism was surprisingly *independent* of the well known Shc/Ras/Raf-1 cascade , and of phosphorylated , so far the only recognized direct activator of ERK1/2 . Regulation ITGB6 TNF 15273742 1296419 *regulates* epithelial expression of MMP-9 and [integrin alphavbeta6] during tumour promotion . Regulation ITGB7 SELL 11504840 847896 These findings show that alpha4beta7 integrin and may *play* an important role in the lymphocyte homing of gastrointestinal low-grade MALT lymphoma and in the loss of [alpha4beta7 integrin] expression throughout the course of high-grade progression . Regulation ITPR1 TNF 18838384 1988266 Herein , we describe a novel neuron-intrinsic pathway in which the expression of the type-1 [inositol 1,4,5-trisphosphate receptor] is *regulated* by the potent pro-inflammatory cytokine . Regulation ITPR1 TNF 19666470 2144031 mediated *regulation* of the [inositol 1,4,5-trisphosphate receptor] promoter . Regulation ITPR1 TNF 25215078 2718837 Several inhibitors including D609 , U73122 , PP1 , safingol , rottlerin and non-radioactive protein kinase C ( PKC ) were used to examine the mechanism of signal transduction of *regulated* [IP3R1] in HMCs . Regulation ITPR2 TNF 18838384 1988267 Herein , we describe a novel neuron-intrinsic pathway in which the expression of the type-1 [inositol 1,4,5-trisphosphate receptor] is *regulated* by the potent pro-inflammatory cytokine . Regulation ITPR2 TNF 19666470 2144032 mediated *regulation* of the [inositol 1,4,5-trisphosphate receptor] promoter . Regulation ITPR3 TNF 18838384 1988268 Herein , we describe a novel neuron-intrinsic pathway in which the expression of the type-1 [inositol 1,4,5-trisphosphate receptor] is *regulated* by the potent pro-inflammatory cytokine . Regulation ITPR3 TNF 19666470 2144033 mediated *regulation* of the [inositol 1,4,5-trisphosphate receptor] promoter . Regulation IVL MAP2K6 11454875 837847 *regulates* human [involucrin] gene expression via a p38alpha - and p38delta -dependent mechanism . Regulation IVL TNF 23283814 2818371 Furthermore , the *regulation* of [involucrin] by interleukin (IL)-13 , IL-17A , endothelin (ET)-1 , , and interferon ( IFN ) -? was investigated by Western blot . Regulation JAG1 ADAM11 20974985 2348719 Upregulation of OX40L and [Jagged-1] by mDC resulted in Th2 *responses* . Regulation JAG1 BACE1 23831026 2815970 Here , we reveal that directly *regulates* the level of membrane anchored full-length [Jagged1 (Jag1)] , a signaling molecule important for the control of neurogenesis and astrogenesis , via interaction with its cognate Notch receptor . Regulation JAG1 EPHB2 19019093 2093244 Selective induction of the Notch ligand [Jagged-1] in macrophages by soluble egg antigen from Schistosoma mansoni *involves* signalling . Regulation JAG1 EPHB2 19019093 2093253 Taken together , our data suggest that [Jagged-1] is an *dependent* target of TLR signalling that has a macrophage-specific function in the response to SEA . Regulation JAG1 EPHB2 20833210 2330859 Increased [Jagged1] expression upon TGFß1 exposure required Smad3 signalling , and was also *regulated* by PI3K and . Regulation JAG1 FGF1 19481073 2102563 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Regulation JAG1 FGF10 19481073 2102564 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Regulation JAG1 FGF11 19481073 2102565 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Regulation JAG1 FGF12 19481073 2102566 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Regulation JAG1 FGF13 19481073 2102567 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Regulation JAG1 FGF14 19481073 2102568 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Regulation JAG1 FGF16 19481073 2102569 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Regulation JAG1 FGF17 19481073 2102570 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Regulation JAG1 FGF18 19481073 2102571 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Regulation JAG1 FGF19 19481073 2102572 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Regulation JAG1 FGF2 19481073 2102573 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Regulation JAG1 FGF2 20436223 2256764 The study analyzed the signalling pathways involved in the regulation of [Jagged-1/Notch-4] expression in endothelial cells ( HUVECs ) in *response* to VEGF , and PPAR-gamma exogenous activator - ciglitazone . Regulation JAG1 FGF2 20436223 2256769 The opposite *effect* of VEGF , , or ciglitazone on the [Jagged-1/Notch-4] expression on HUVEC was connected with the different activation of MAPKs . Regulation JAG1 FGF20 19481073 2102574 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Regulation JAG1 FGF21 19481073 2102575 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Regulation JAG1 FGF22 19481073 2102576 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Regulation JAG1 FGF23 19481073 2102577 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Regulation JAG1 FGF3 19481073 2102578 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Regulation JAG1 FGF4 19481073 2102579 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Regulation JAG1 FGF5 19481073 2102580 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Regulation JAG1 FGF6 19481073 2102581 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Regulation JAG1 FGF7 19481073 2102582 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Regulation JAG1 FGF8 19481073 2102583 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Regulation JAG1 FGF9 19481073 2102584 Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased *dependent* expression of [Jag1] demonstrating Notch dependent lateral induction . Regulation JAG1 HEY2 15389319 1300396 To clarify the *role* of in human CHD and [AGS] , we screened by direct sequencing 23 children with CHD and 38 patients diagnosed with AGS , which lack mutations in the JAG1 gene . Regulation JAG1 HGF 16403414 1513225 Furthermore , [JAG1] *controls* expression by a dosage dependent regulation and Notch2 signaling seems to mediate JAG1 function . Regulation JAG1 HOXD3 12836255 895753 *regulates* expression of [JAGGED1] , a ligand for Notch receptors . Regulation JAG1 IFNA1 18461501 1840395 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Regulation JAG1 IFNA10 18461501 1840396 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Regulation JAG1 IFNA13 18461501 1840397 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Regulation JAG1 IFNA14 18461501 1840398 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Regulation JAG1 IFNA16 18461501 1840399 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Regulation JAG1 IFNA17 18461501 1840400 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Regulation JAG1 IFNA2 18461501 1840401 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Regulation JAG1 IFNA21 18461501 1840402 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Regulation JAG1 IFNA4 18461501 1840403 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Regulation JAG1 IFNA5 18461501 1840404 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Regulation JAG1 IFNA6 18461501 1840405 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Regulation JAG1 IFNA7 18461501 1840406 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Regulation JAG1 IFNA8 18461501 1840407 In [Aicardi-Goutières syndrome (AGS)] , as in systemic lupus erythematosus ( SLE ) and Sjögren 's syndrome , an increased level of is *involved* in the pathogenesis of the disease . Regulation JAG1 MYLIP 22336710 2624248 Here we report the validation of miRNA-target interactions we predicted earlier and demonstrate the *regulation* of endogenous [JAG1] by and hsa-miR-124 , and TGFBR2 by hsa-miR-34b* , through luciferase activity of reporter constructs and also the expression levels of the endogenous genes . Regulation JAG1 MYLIP 23028429 2679680 We cloned the full length 3'UTR of Amex-Jag1 , and our in vitro assays demonstrated that its single miR-21 target recognition site is functional and essential for the *response* of the [Jagged1] gene to levels . Regulation JAG1 NEURL 18077452 1862012 targeted to the plasma membrane by N-myristoylation *regulates* the Notch ligand [Jagged1] . Regulation JAG1 NEURL 18077452 1862018 Taken together , our results argue that at the plasma membrane can *affect* the signaling activity of [Jagged1] by directly enhancing its ubiquitination and subsequent turnover . Regulation JAG1 NFKB1 10329626 613635 Consistent with its *dependent* induction , [Jagged1] was found to be highly expressed in splenic B cells where c-Rel is expressed constitutively . Regulation JAG1 NOTCH1 15850833 1399431 Diverse *effects* of the ligands [Jagged1] and Delta1 on the growth and differentiation of primary acute myeloblastic leukemia cells . Regulation JAG1 NOTCH1 23752887 2801934 Renal involvement and the *role* of signalling in [Alagille syndrome] . Regulation JAG1 NOTCH1 25100656 2954314 We also tested mediated *regulation* of [Jag1] and Pax6 in the distal retina , to establish the appropriate context for Neurog2 patterning . Regulation JAG1 NOTCH2 15850833 1399432 Diverse *effects* of the ligands [Jagged1] and Delta1 on the growth and differentiation of primary acute myeloblastic leukemia cells . Regulation JAG1 NOTCH2 23752887 2801935 Renal involvement and the *role* of signalling in [Alagille syndrome] . Regulation JAG1 NOTCH2 25100656 2954315 We also tested mediated *regulation* of [Jag1] and Pax6 in the distal retina , to establish the appropriate context for Neurog2 patterning . Regulation JAG1 NOTCH3 12456485 1021208 This study documents the *regulation* of the [Jagged-1] and Notch-3 genes in VSMCs by growth factor stimulation as well as a role for as a determinant of VSMC growth . Regulation JAG1 NOTCH3 15850833 1399433 Diverse *effects* of the ligands [Jagged1] and Delta1 on the growth and differentiation of primary acute myeloblastic leukemia cells . Regulation JAG1 NOTCH3 18060036 1833878 IL-6 treatment triggered *dependent* upregulation of the Notch ligand [Jagged-1] and promotion of MS and MCF-7 derived spheroid growth . Regulation JAG1 NOTCH3 23752887 2801936 Renal involvement and the *role* of signalling in [Alagille syndrome] . Regulation JAG1 NOTCH3 25100656 2954316 We also tested mediated *regulation* of [Jag1] and Pax6 in the distal retina , to establish the appropriate context for Neurog2 patterning . Regulation JAG1 NOTCH4 15850833 1399434 Diverse *effects* of the ligands [Jagged1] and Delta1 on the growth and differentiation of primary acute myeloblastic leukemia cells . Regulation JAG1 NOTCH4 23752887 2801937 Renal involvement and the *role* of signalling in [Alagille syndrome] . Regulation JAG1 NOTCH4 25100656 2954317 We also tested mediated *regulation* of [Jag1] and Pax6 in the distal retina , to establish the appropriate context for Neurog2 patterning . Regulation JAG1 OXA1L 22336710 2624249 Here we report the validation of miRNA-target interactions we predicted earlier and demonstrate the *regulation* of endogenous [JAG1] by hsa-miR-214 and , and TGFBR2 by hsa-miR-34b* , through luciferase activity of reporter constructs and also the expression levels of the endogenous genes . Regulation JAG1 PIK3CA 20833210 2330860 Increased [Jagged1] expression upon TGFß1 exposure required Smad3 signalling , and was also *regulated* by and ERK . Regulation JAG1 PIK3R1 20833210 2330861 Increased [Jagged1] expression upon TGFß1 exposure required Smad3 signalling , and was also *regulated* by and ERK . Regulation JAG1 PPARG 20436223 2256765 The study analyzed the signalling pathways involved in the regulation of [Jagged-1/Notch-4] expression in endothelial cells ( HUVECs ) in *response* to VEGF , bFGF and exogenous activator - ciglitazone . Regulation JAG1 PRH1 15919063 1420406 These neurophysiological and microinjection findings support a critical *role* of in generation of this [AGS] kindling induced convulsive behavior . Regulation JAG1 PRH2 15919063 1420407 These neurophysiological and microinjection findings support a critical *role* of in generation of this [AGS] kindling induced convulsive behavior . Regulation JAG1 REL 10329626 613636 Consistent with its *dependent* induction , [Jagged1] was found to be highly expressed in splenic B cells where c-Rel is expressed constitutively . Regulation JAG1 RELA 10329626 613637 Consistent with its *dependent* induction , [Jagged1] was found to be highly expressed in splenic B cells where c-Rel is expressed constitutively . Regulation JAG1 SERPINE1 15304113 1284516 Both IL-8 and GRO-alpha were produced by both [AGS] and KATO-III cells in response to H. pylori infection , and in a cag *dependent* manner . Regulation JAG1 STX7 12730232 1106854 To elucidate the molecular mechanism of VacA induced vacuolation , we examined the *participation* of in the human gastric epithelial cell line [AGS] . Regulation JAG1 VEGFA 20436223 2256768 The opposite *effect* of , bFGF , or ciglitazone on the [Jagged-1/Notch-4] expression on HUVEC was connected with the different activation of MAPKs . Regulation JAK1 TNF 15087472 1258137 Stimulatory *effects* of on neuropeptide gene expression and release appeared to be mediated through the type 2 TNF-alpha receptor , and required activation of ERK 1/2 and p38 , but not [Janus kinase] , MAPKs . Regulation JAK2 CCND1 19638583 2118636 We have recently reported that [Jak2] *controls* the expression and nuclear accumulation of . Regulation JAK2 IL1B 16959849 1639710 Although there was no *effect* of on the phosphorylation of ELK , [Janus kinase 2] , or signal transducers and activators of transcription ( STAT ) 1 , IL-1beta significantly increased tyrosine-phosphorylation of STAT3 , an effect attenuated by PD98059 . Regulation JAK2 TNF 15087472 1258138 Stimulatory *effects* of on neuropeptide gene expression and release appeared to be mediated through the type 2 TNF-alpha receptor , and required activation of ERK 1/2 and p38 , but not [Janus kinase] , MAPKs . Regulation JAK3 TNF 15087472 1258139 Stimulatory *effects* of on neuropeptide gene expression and release appeared to be mediated through the type 2 TNF-alpha receptor , and required activation of ERK 1/2 and p38 , but not [Janus kinase] , MAPKs . Regulation JUN ALOX5 18498541 1917577 We then investigated whether these drugs affect NF-kappaB and [AP-1] activities in A549 lung epithelial cells , and whether this potential regulation *involves* H1-receptor and <5-LO> . Regulation JUN CCND1 9655520 516271 The Fos protein forms the heterodimer [AP-1] with the Jun protein and *regulates* the cell cycle by inducing . Regulation JUN CD14 17583593 1798094 The decrease in expression caused by morphine may *play* a role in inhibition of [activator protein 1] activation following lipopolysaccharide treatment of phagocytes . Regulation JUN EDN2 1314833 185346 Differential *regulation* of fos and jun gene expression and [AP-1] cis-element activity by isopeptides . Regulation JUN EPHB2 11104676 756454 Compartment-specific *regulation* of extracellular signal regulated kinase ( ERK ) and [c-Jun N-terminal kinase (JNK)] mitogen activated protein kinases ( MAPKs ) by dependent and non-ERK dependent inductions of MAPK phosphatase (MKP)-3 and MKP-1 in differentiating P19 cells . Regulation JUN EPHB2 14729583 1235008 In order to clarify the *roles* of p38 and in TPA induced [AP-1] activation , we utilized the pharmacologic inhibitors of these enzymes . Regulation JUN EPHB2 14734742 1199427 Of interest , MEKK1 immunoprecipitates from IL-1 stimulated FLS appeared to activate c-Jun through the JNK pathway and TAK1 activation of [c-Jun] was *dependent* on JNK , , and p38 . Regulation JUN EPHB2 15063796 1231001 These studies show that in mouse keratinocytes MMP-13 gene expression can be induced through a Runx independent pathway that involves the *dependent* modulation of [AP-1] . Regulation JUN EPHB2 17111371 1667731 Here we studied the activation of [AP-1] proteins in *response* to , JNK , and p38 signaling upon NGF , EGF and anisomycin exposures . Regulation JUN EPHB2 17116726 1724521 Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the *dependent* [c-Jun/AP-1] induction of MMP-2 . Regulation JUN EPHB2 18093576 1868708 We observed that and JNK , but not p38 MAP kinase , are *involved* in BPDE induced [AP-1] activation . Regulation JUN EPHB2 19935718 2210119 In addition , OHT induced *dependent* expression of c-Fos and transactivation of an [AP-1-responsive] promoter . Regulation JUN EPHB2 24065532 2857752 Also , COX-2 and MMP-9 expressions are attenuated through the inhibition of AP-1 transcription activity via the downregulation of [c-Jun] expression *regulated* by p38 , and JNK signaling . Regulation JUN EPHB2 9687508 522226 Differential *regulation* of [c-Jun] by and JNK during PC12 cell differentiation . Regulation JUN FAS 11689460 876271 CD40 activation induced , *dependent* apoptosis and [NF-kappaB/AP-1] signaling in human intrahepatic biliary epithelial cells . Regulation JUN FAS 12556535 1071636 Apoptosis signal regulating kinase 1 ( ASK1 ) is a MAP kinase kinase kinase ( MAPKKK ) that is required for [c-Jun N-terminal kinase (JNK)] and p38 activation in *response* to and tumor necrosis factor (TNF) receptor stimulation , and for oxidative stress- and TNFalpha induced apoptosis . Regulation JUN IL1B 11028561 739584 The *effect* of on [AP-1] activity in the enterocyte and the potential role of AP-1 in enterocyte IL-6 production are not known . Regulation JUN IL1B 11028561 739595 These results suggest that the AP-1 family of transcription factors is activated by in human enterocytes and that [AP-1] may at least in part *regulate* IL-6 production in these cells . Regulation JUN IL1B 11930749 894650 induced cytotoxicity via activating JNK pathway and [transcription factor AP-1] and the simultaneous activation of p38 kinase pathway negatively *regulated* this process . Regulation JUN IL1B 16417227 1514517 Pseudomonas aeruginosa- and mediated induction of human beta-defensin-2 in keratinocytes is *controlled* by NF-kappaB and [AP-1] . Regulation JUN IL1B 18001575 1827115 After being treated with different doses of IL-1 beta for 24 hours , the *effect* of on the expressions of GS and [c-Jun] in retinal Müller cells in the control and experimental groups was measured by western blot analysis and indirect immunofluorescence . Regulation JUN IL1B 19839866 2155211 The *effect* of on the expression of glutamine synthetase and [c-Jun] in retinal Müller cells under normal and high glucose conditions was measured by immunocytochemistry , Western blot , and real-time ( RT ) PCR , and was further confirmed by c-Jun siRNA method . Regulation JUN MAP2K6 10585392 571155 The [c-Jun] activation caused by Sgn2 overexpression is *independent* of JNK and 4 . Regulation JUN MAP2K6 21278800 2398239 Here , we show that RASSF7 interacts with N-Ras and 7 ( MKK7 ) to negatively *regulate* [c-Jun N-terminal kinase (JNK)] signaling . Regulation JUN MAP2K6 9710582 526687 The effect of Rho on AP-1 is independent of the mitogen activated protein kinase pathway , as a dominant negative and a MEK inhibitor ( PD98059 ) did not *affect* Rho induced [AP-1] activity . Regulation JUN RARB 12123542 965451 To investigate the *role* of in mediating inhibitory effect of all-trans retinoic acid ( ATRA ) on [activator protein-1 (AP-1)] activity in gastric cancer cells . Regulation JUN TNF 10367939 561441 In the present study , we have investigated the *effects* of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ) , interleukin-10 (IL-10) and -13 ( IL-13 ) , transforming growth factor-beta1 ( TGF-beta1 ) , granulocyte-macrophage colony stimulating factor ( GM-CSF ) , and on cell proliferation and induction of transcription factors [AP-1] and NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro . Regulation JUN TNF 10564845 567346 The system successfully simulated the molecular process steps underlying outcomes of eight different molecular genetics laboratory experiments , including those dealing with NF-kappaB and [AP-1] regulation in immunodeficiency virus infection and *responses* . Regulation JUN TNF 11007940 735628 *Regulation* of nuclear factor-kappa B , [activator protein-1] , and glutathione levels by and dexamethasone in alveolar epithelial cells . Regulation JUN TNF 11007940 735632 The promoter regions of the human gamma-GCS subunits contain [AP-1] , NF-kappa B , and antioxidant response elements and are *regulated* by oxidants , growth factors , inflammatory cytokine , and anti-inflammatory agent ( dexamethasone ) in lung cells . Regulation JUN TNF 12665585 1074940 c-Jun NH ( 2 ) -terminal kinase is essential for the *regulation* of [AP-1] by . Regulation JUN TNF 12665585 1074942 We show that JNK is required for the normal *regulation* of [AP-1] by . Regulation JUN TNF 1281483 205707 These observations suggest that the inhibitory *effects* of on elastin gene expression involve the [transcription factor AP-1] . Regulation JUN TNF 14661063 1218764 Keratinocyte derived acts as an endogenous tumour promoter and can also *regulate* [AP-1] activity in mouse epidermis . Regulation JUN TNF 14692400 581721 In this report , we investigated the *effect* of on activation of NF-kappa B , [c-Jun N-terminal kinase (JNK)] , and apoptosis in vincristine-resistant human histiocytic lymphoma U937-VR cells . Regulation JUN TNF 15033544 1223532 Also , the *participation* of and oxidative stress in [AP-1] activation was evaluated . Regulation JUN TNF 16783201 1573689 Thermal injury also induces *dependent* delay apoptosis and TNF-alpha independent [AP-1] activation of neutrophil at 3 h after thermal injury . Regulation JUN TNF 17015619 1629448 Consistent with this , FIP200 KO mouse embryo fibroblasts and liver cells showed increased apoptosis and reduced [c-Jun] N-terminal kinase phosphorylation in *response* to alpha stimulation , which might be mediated by FIP200 interaction with apoptosis signal regulating kinase 1 ( ASK1 ) and TNF receptor associated factor 2 (TRAF2) , regulation of TRAF2-ASK1 interaction , and ASK1 phosphorylation . Regulation JUN TNF 17227768 1703825 We tested whether mitogenic activated protein kinase kinase kinase kinase isoform 4 ( MAP4K4 ) causes the induced negative *regulation* of extracellular signal regulated kinase-1/2 ( ERK-1/2 ) , [c-Jun NH2-terminal kinase (JNK)] , and the insulin receptor substrate-1 (IRS-1) on the insulin signaling pathway governing glucose metabolism . Regulation JUN TNF 22941947 2678528 In *response* to interleukin-1 , , and toll-like receptor agonists , it mediates the activation of the nuclear factor ?B ( NF-?B ) , [c-Jun N-terminal kinase (JNK)] , and p38 pathways . Regulation JUN TNF 9368689 463885 The *effect* of and cAMP on induction of [AP-1] activity in MA-10 tumor Leydig cells . Regulation JUN TNF 9531270 496769 Overexpression of the p80 TNF receptor leads to *dependent* apoptosis , nuclear factor-kappa B activation , and [c-Jun] kinase activation . Regulation JUN TNF 9933633 589484 Here we show that extracellular signal regulated kinase ( ERK ) , [c-Jun N-terminal kinase (JNK)] , and p38-mitogen activated protein kinase (MAPK) pathways *control* the transcription and synthesis of in A3.01 T cells that produce the cytokine upon T cell activation by costimulation with 12-O-tetradecanoylphorbol-13-acetate ( TPA ) and ionomycin . Regulation JUNB EPHB2 11854297 929510 To determine the roles of MAPK in BMP-2 and TGF-beta function , we analyzed the *effect* of and p38 inhibitors on the regulation of bone matrix protein expression and [JunB] and JunD levels by these two factors . Regulation JUNB EPHB2 16115217 1448854 Additionally , chronic blocking of activation *affected* cocaine induced c-Fos and [JunB] but not Zif268 expression . Regulation JUNB MUC16 24812549 2939849 The loss of activated Stat3 signal , *affected* [JunB] signal , and upregulated the expression of IL-6 in the conjunctiva . Regulation JUND EPHB2 11854297 929512 To determine the roles of MAPK in BMP-2 and TGF-beta function , we analyzed the *effect* of and p38 inhibitors on the regulation of bone matrix protein expression and JunB and [JunD] levels by these two factors . Regulation JUND EPHB2 14676207 1211131 Here we show that these motifs mediate [JunD] phosphorylation in *response* to either or JNK activation . Regulation KANK2 EPHB2 19723624 2152279 [SIP30] is *regulated* by in peripheral nerve injury induced neuropathic pain . Regulation KANK4 BAIAP2 19171758 2027768 Our results demonstrate that [Kank] negatively *regulates* the formation of lamellipodia by inhibiting the interaction between Rac1 and . Regulation KANK4 EGF 18458160 1909413 The interaction between [Kank] and 14-3-3 is *regulated* by insulin and and is mediated through phosphorylation of Kank by Akt . Regulation KANK4 INS 18458160 1909414 The interaction between [Kank] and 14-3-3 is *regulated* by and EGF and is mediated through phosphorylation of Kank by Akt . Regulation KANK4 RAC1 19171758 2027769 Our results demonstrate that [Kank] negatively *regulates* the formation of lamellipodia by inhibiting the interaction between and IRSp53 . Regulation KAT2B STAT4 14660657 1202292 In this report , we utilize chromatin immunoprecipitation assays to analyze IL-12 stimulated and *dependent* changes in [chromatin remodeling] of the CD25 gene . Regulation KCNA1 TLR7 20730378 2313335 Selective inhibitors of [Kv11] .1 regulate IL-6 expression by macrophages in *response* to ligands . Regulation KCNE1 BACE1 23504710 2787695 Together , these results clearly showed that [KCNE1] and KCNE2 cleavages are *regulated* by and PS/?-secretase activities under physiological conditions . Regulation KCNE1 PIP 14532114 1152236 Here we show that ( 2 ) and intracellular MgATP *control* the activity of the [KCNQ1/KCNE1] potassium channel complex . Regulation KCNE1 PRKAA1 21231794 2379634 The present study explored whether *regulates* [KCNQ1/KCNE1] . Regulation KCNE1 PRKAA2 21231794 2379635 The present study explored whether *regulates* [KCNQ1/KCNE1] . Regulation KCNE1 PRKAB1 21231794 2379636 The present study explored whether *regulates* [KCNQ1/KCNE1] . Regulation KCNE1 PRKAB2 21231794 2379637 The present study explored whether *regulates* [KCNQ1/KCNE1] . Regulation KCNE1 PRKAG1 21231794 2379638 The present study explored whether *regulates* [KCNQ1/KCNE1] . Regulation KCNE1 PRKAG2 21231794 2379639 The present study explored whether *regulates* [KCNQ1/KCNE1] . Regulation KCNE1 SGK1 15107590 1240624 We conclude that the *regulation* of [KCNE1/KCNQ1] by is similarly relevant for the repolarization of cardiac myocytes as for regulation of renal ENaC activity and blood pressure control . Regulation KCNH4 EPHB2 10813377 693233 We used GAL-Elk-1 expression plasmids to detect *dependent* activation of [Elk-1] . Regulation KCNH4 EPHB2 11283246 799355 ( ii ) interfering mutants of Ras and Rap1 both inhibit ERK kinase activity and *dependent* [Elk1] transcriptional activation in response to TPO ; Regulation KCNH4 EPHB2 15292266 1303141 Taken together these results demonstrate that S1P activates multiple signaling pathways in SMC and regulates proliferation by *dependent* activation of [Elk-1] and differentiation by RhoA dependent activation of MRTF-A . Regulation KCNH4 EPHB2 17082637 1643386 Our findings collectively indicate that signaling *plays* key roles in both [Elk1] , CREB , and ATF-1 activation and the subsequent recruitment of c-Jun to the FRA-1 promoter in response to TNF-alpha in pulmonary epithelial cells . Regulation KCNH4 MAP2K6 12454853 1021040 Furthermore , *involvement* of Ras and in CagA mediated [Elk1] phosphorylation was observed . Regulation KCNH4 MAP2K6 19342628 2056773 FcgammaRIIIB induced nuclear phosphorylation of ERK , and of [Elk-1] , was not *affected* by Syk , PI3K , or inhibitors . Regulation KCNH4 TNF 17082637 1643385 Our findings collectively indicate that ERK signaling plays key roles in both [Elk1] , CREB , and ATF-1 activation and the subsequent recruitment of c-Jun to the FRA-1 promoter in *response* to in pulmonary epithelial cells . Regulation KCNK3 CDC73 15184378 1273783 We set out to determine the cellular mechanisms that control *regulation* of [TASK-1] by . Regulation KCNK3 CTR9 15184378 1273784 We set out to determine the cellular mechanisms that control *regulation* of [TASK-1] by . Regulation KCNK3 EDN1 19188660 2127797 The *effect* on membrane potential and [TASK-1] was abrogated using TASK-1 siRNA . Regulation KCNK3 LEO1 15184378 1273787 We set out to determine the cellular mechanisms that control *regulation* of [TASK-1] by . Regulation KCNK3 NOX4 19657056 2143648 We also found that p22 is required for the dependent [TASK-1] *regulation* . Regulation KCNK3 NOX4 19657056 2143649 In this process , the heme moiety and FBD seem to be responsible for the *regulation* of [TASK-1] , and p22 might support the NOX4-TASK-1 interaction . Regulation KCNK3 PAF1 15184378 1273785 We set out to determine the cellular mechanisms that control *regulation* of [TASK-1] by . Regulation KCNK3 PRKAA1 19840997 2170066 Here , we characterize *effects* of activated on recombinant [TASK-1] , TASK-3 , TREK-1 and TREK-2 background K ( + ) channels expressed in HEK293 cells . Regulation KCNK3 PRKAA2 19840997 2170067 Here , we characterize *effects* of activated on recombinant [TASK-1] , TASK-3 , TREK-1 and TREK-2 background K ( + ) channels expressed in HEK293 cells . Regulation KCNK3 PRKAB1 19840997 2170068 Here , we characterize *effects* of activated on recombinant [TASK-1] , TASK-3 , TREK-1 and TREK-2 background K ( + ) channels expressed in HEK293 cells . Regulation KCNK3 PRKAB2 19840997 2170069 Here , we characterize *effects* of activated on recombinant [TASK-1] , TASK-3 , TREK-1 and TREK-2 background K ( + ) channels expressed in HEK293 cells . Regulation KCNK3 PRKACB 16574908 1550027 This is mediated via *dependent* phosphorylation of [TASK-1] . Regulation KCNK3 PRKACG 16574908 1550028 This is mediated via *dependent* phosphorylation of [TASK-1] . Regulation KCNK3 PRKAG1 19840997 2170070 Here , we characterize *effects* of activated on recombinant [TASK-1] , TASK-3 , TREK-1 and TREK-2 background K ( + ) channels expressed in HEK293 cells . Regulation KCNK3 PRKAG2 19840997 2170071 Here , we characterize *effects* of activated on recombinant [TASK-1] , TASK-3 , TREK-1 and TREK-2 background K ( + ) channels expressed in HEK293 cells . Regulation KCNK3 PRKAR1A 16574908 1550029 This is mediated via *dependent* phosphorylation of [TASK-1] . Regulation KCNK3 PRKAR1B 16574908 1550030 This is mediated via *dependent* phosphorylation of [TASK-1] . Regulation KCNK3 PRKAR2A 16574908 1550031 This is mediated via *dependent* phosphorylation of [TASK-1] . Regulation KCNK3 PRKAR2B 16574908 1550032 This is mediated via *dependent* phosphorylation of [TASK-1] . Regulation KCNK3 TRH 11886861 937338 TASK-1 and TASK-3 differed insofar as a large portion of the C terminus was necessary for the full *effects* of halothane and on TASK-3 but not on [TASK-1] . Regulation KCNK3 WDR61 15184378 1273786 We set out to determine the cellular mechanisms that control *regulation* of [TASK-1] by . Regulation KCNMA1 CLU 19805566 2187025 We aimed to evaluate the *effect* of on the in vitro production of three major virulent exoproteins , namely , [streptolysin O (Slo)] , NAD glycohydrolase ( Nga ) , and streptokinase (Ska) , by CLI-resistant S. pyogenes strains . Regulation KCNMA1 FBXO32 22586590 2614382 Reactive oxygen species signaling facilitates *dependent* vascular [BK channel] ß1 subunit degradation in diabetic mice . Regulation KCNQ1 KCNE1 19687231 2133032 Conversely , S6 mutations ( S338C and F340C ) that alter and KCNE3 *effects* on [KCNQ1] do not abrogate KCNE4 inhibition . Regulation KCNQ1 KCNE1 19687231 2133034 These observations indicate that the diverse functional effects observed for KCNE proteins depend , in part , on structures intrinsic to the pore forming subunit , and that distinct S6 subdomains determine [KCNQ1] *responses* to , KCNE3 , and KCNE4 . Regulation KCNQ1 KCNE1 21576273 2454035 Previous work on the kidney of KCNE1 and KCNQ1 knockout mice has revealed that these animals have different renal phenotypes , suggesting that may not *regulate* [KCNQ1] in the renal system . Regulation KDR RCAN1 20625401 2291759 Our data suggests that RCAN1 .4 expression is induced by [VEGFR-2] activation in a Ca ( 2+ ) and PKC-delta dependent manner and that .4 *acts* to regulate calcineurin activity and gene expression facilitating endothelial cell migration and tubular morphogenesis . Regulation KDR TNF 14532277 1174867 In *response* to , Etk and [VEGFR2] form a complex resulting in a reciprocal activation between the two kinases . Regulation KHSRP EPHB2 24026251 2846118 These results suggest that Sp1 mediated [p75NTR] expression is *regulated* at least in part by and CK2 pathways . Regulation KHSRP TNF 23861542 2817280 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for [p75-specific] activation of NF-?B and MAPK signaling . Regulation KIAA0226 TLR7 22423966 2573024 Autophagy protein [Rubicon] mediates phagocytic NADPH oxidase activation in *response* to microbial infection or stimulation . Regulation KIDINS220 CAPN8 20943655 2353690 These results provide an explanation for a role for the ARMS/Kidins220 protein in synaptic plasticity events and suggest that the levels of [ARMS/Kidins220] can be *regulated* by neuronal activity and action to influence synaptic function . Regulation KIF18A STK39 18083840 1837767 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation KIF2A STK39 18083840 1837842 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation KIF2B STK39 18083840 1837782 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation KIF2C STK39 18083840 1837857 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation KIT ANO1 23576565 2799910 Here , we report that loss of DOG1 expression occurs together with loss of KIT expression in a subset of GIST resistant to KIT inhibitors , and we illustrate the functional *role* of in tumor growth , [KIT] expression , and imatinib response . Regulation KIT TNF 7514454 241724 In this study we evaluated the *effect* of on the expression of [SCF-R] by flow cytometry . Regulation KLF2 EPHB2 18218985 1876709 Shear stress induced extracellular signal regulated kinase ( ) 5 activation and the consequent *regulation* of [Kruppel-like factor 2] and endothelial nitric oxide synthase expression represents one of the antiinflammatory and vascular tone regulatory mechanisms maintaining normal endothelial function . Regulation KLF2 F2R 23395513 2818523 The purpose of this study was to explore the expression of KLF2 and in vulnerable plaques of ApoE gene knockout ( ApoE ( -/- ) ) mice and the pharmaceutical *effect* of statin on the expression of [KLF2] and PAR-1 . Regulation KLF2 FOXO1 19136962 2025517 In naive T cells , *controlled* the expression of the adhesion molecule L-selectin , the chemokine receptor CCR7 and the transcription factor [Klf2] , and its deletion was sufficient to alter lymphocyte trafficking . Regulation KLF2 FOXO1 19136962 2025523 Finally , growth factor withdrawal induced a *dependent* increase in Sell , [Klf2] and Il7r expression . Regulation KLF2 SELL 17548599 1752294 These findings suggest that [KLF2] *regulates* T cell homeostasis at least partly by controlling and S1P1 expression , and therefore T cell egress from the thymus and circulation in the periphery . Regulation KLF2 SELL 19592277 2111958 The transcription factor [KLF2] *regulates* T cell trafficking by promoting expression of the lipid binding receptor S1P(1) and the selectin . Regulation KLF9 NOTCH1 21280156 2387722 We also show that [KLF9] *regulates* GBM neurosphere cells by binding to the Notch1 promoter and suppressing expression and downstream signaling . Regulation KLF9 NR2F1 24349493 2881283 Based on this , we performed chromatin-immunoprecipitation followed by qRT-PCR and confirmed that directly binds and *regulates* both miR-140 and [Klf9] in vivo . Regulation KLK3 BPI 11072604 748755 Due to its relationship with local inflammation , SF may *play* a role in the pathogenesis of arthropathies , in particular [PsA] . Regulation KLK3 EPHB2 16282370 1525967 Stress kinase inhibition of PSA transcription is , therefore , dependent on the AR. Similar experiments involving either activation or inhibition of MAPK/ERK kinase : signaling had little *effect* on Ser 650 phosphorylation or [PSA] mRNA levels . Regulation KLK3 TNF 11246532 793269 To explore the possible *involvement* of the proinflammatory and prothrombotic cytokine in [APS] by determining the plasma levels in patients and to test for association of TNFA promoter polymorphisms and HLA class II genotypes with both plasma TNFalpha and disease . Regulation KLK3 TNF 20586498 2280657 *plays* a key pathophysiological role in psoriasis and [psoriatic arthritis (PsA)] . Regulation KLK3 TNF 22480318 2606812 *plays* a central role in [psoriatic arthritis (PsA)] . Regulation KLKB1 NR2F1 21266512 2392726 Thyroid hormone and *regulate* [kallikrein binding protein (KBP)] gene expression . Regulation KLRB1 IL1B 20543587 2271743 Human Th17 cells express [CD161] and exclusively originate from CD161 precursors present in umbilical cord blood and newborn thymus in *response* to the combined activity of and IL-23 . Regulation KNG1 TNF 1704100 146581 Differential *regulation* of rat [T-kininogen] by and interleukin-6 . Regulation KNTC1 ELOVL4 22199362 2617283 Conditional knock-out mice were also found to have abnormal accumulation of lipid droplets and lipofuscin-like granules while demonstrating photoreceptor-specific abnormalities in visual response , indicating the critical *role* of for proper [rod] or cone photoreceptor function . Regulation KNTC1 LAMB3 11139649 758899 Three candidate models were quantitatively optimized to the Murnick & saturated toad [rod] flash *responses* and , simultaneously , to a set of sub saturated flash responses . Regulation KPNA4 LGALS7B 1990281 152367 Finally , a strain was constructed in which transcription of the [SRP3] gene was *controlled* by the inducible promoter . Regulation KRAS AXIN2 17374607 1734761 The [Ras] *regulation* by was blocked by treatment of leupeptin , an inhibitor of the lysosomal protein degradation machinery . Regulation KRAS EPHB2 10978313 751960 Whereas the essential *roles* of and JNK in [Ras] signaling has been established , the contribution of p38 remains unclear . Regulation KRAS EPHB2 17724343 1789864 Subcellular compartmentalization has become an important theme in cell signaling such as spatial *regulation* of [Ras] by RasGRP1 and by Sef . Regulation KRAS EPHB2 17873330 1796092 The aim of this work is to evaluate if [Ras] can be induced by TSH in rat thyroids , and whether may be *involved* in the subsequent intracellular signalling cascade . Regulation KRAS EPHB2 21277645 2457909 Furthermore , , a critical growth *regulator* downstream of [RAS] , may play a role . Regulation KRAS FAS 20418879 2262478 Small-molecule inhibition of *affects* [Ras] localization and signaling . Regulation KRAS FAS 9829751 551129 However , in the presence of oncogenic [K-Ras] , survival did not *involve* down-regulation of or FasL expression but did involve members of the Bcl-2 family . Regulation KRAS FHL1 23456229 2781828 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Regulation KRAS GPR115 14656216 1176992 Role of receptor tyrosine kinases in *regulation* of [Ras] : transactivation or parallel pathways ? Regulation KRAS GPR132 14656216 1176981 Role of receptor tyrosine kinases in *regulation* of [Ras] : transactivation or parallel pathways ? Regulation KRAS GPR87 14656216 1177061 Role of receptor tyrosine kinases in *regulation* of [Ras] : transactivation or parallel pathways ? Regulation KRAS MAP2K6 17724343 1789870 Subcellular compartmentalization has become an important theme in cell signaling such as spatial *regulation* of [Ras] by RasGRP1 and by Sef . Regulation KRAS MAP2K6 24108744 2896378 Consistent with these findings , changes in EMT phenotypes and markers were also induced by the expression of mutant [KRAS] in a *dependent* manner . Regulation KRR1 EPHB2 16948396 1610027 Neither JNK nor inhibition had a significant *effect* on cytokine mediated inhibition of [RIP1] activity . Regulation KRR1 TNF 24113711 2852673 We show that Pellino3 targets RIP1 , in a *dependent* manner , to inhibit TNF induced complex II formation and caspase 8-mediated cleavage of [RIP1] in response to TNF/cycloheximide co-stimulation . Regulation KRT38 AP2A1 7517240 243611 Thus , the *role* of in [keratin] gene expression is quantitative rather than qualitative . Regulation KRT38 AP2B1 7517240 243304 Transcription factor *plays* an important role in transcription of [keratin] genes , and it has been suggested that AP2 confers epithelial specificity . Regulation KRT38 AP2M1 7517240 243305 Transcription factor *plays* an important role in transcription of [keratin] genes , and it has been suggested that AP2 confers epithelial specificity . Regulation KRT38 AP2M1 7517240 243612 Thus , the *role* of in [keratin] gene expression is quantitative rather than qualitative . Regulation KRT38 AP2S1 7517240 243306 Transcription factor *plays* an important role in transcription of [keratin] genes , and it has been suggested that AP2 confers epithelial specificity . Regulation KRT38 CISH 1708801 155169 The aim of this study was to determine the *effects* of <13-cis-RA> , all-trans-RA , and acitretin on the proliferation , lipid synthesis , and [keratin] expression of human sebocytes in vitro and to elucidate possible mechanisms of retinoid action on sebaceous glands at the cellular level . Regulation KRT38 CTNNB1 14610062 1162709 In contrast , Lef1 is up-regulated , but its regulated control of hair differentiation is still blocked , and BMPRIA-null follicles fail to activate *regulated* genes , including [keratin] genes . Regulation KRT38 DLX3 22442153 2594629 Our results demonstrate that regulation of by HR *affects* the IRS [keratin] expression , thus modulating the formation of IRS of hair follicle . Regulation KRT38 EGF 7537080 300825 We have recently shown that and transforming growth factor beta ( TGF beta ) , modulators of keratinocyte proliferation , *regulate* expression of specific [keratin] genes . Regulation KRT38 EGFR 7688128 225202 We have analyzed the *effects* of activation on [keratin] gene transcription by transfecting DNAs containing keratin promoters linked to a reporter gene into primary cultures of human epidermal keratinocytes in the presence or absence of EGF or transforming growth factor alpha ( TGF alpha ) , two growth factors that activate EGFR . Regulation KRT38 FGF7 7537080 300443 and [keratin] gene *regulation* . Regulation KRT38 FOXN1 10767081 684790 Forkhead/winged-helix transcription factor *regulates* hair [keratin] gene expression : molecular analysis of the nude skin phenotype . Regulation KRT38 FOXN1 11054532 745704 Among other functions , ( formerly known as Whn ) *regulates* the expression of hair [keratin] genes in the hair follicle , which represents an evolutionarily novel organ characteristic of mammals . Regulation KRT38 FOXN1 17938256 1866500 however , how *regulates* hair [keratin] expression and hair formation is largely unknown . Regulation KRT38 FUT1 20151404 2227574 Using CHIP-p.Met1_Ala142del ( DeltaTPR-CHIP ) , we demonstrated the *involvement* of and Hsp70 in mutant [keratin] degradation . Regulation KRT38 GRAP2 17535969 1751741 Collectively , the rapid and reversible *effects* of activity on [keratin] phosphorylation and organization in diverse physiological , stress , and pathological situations identify p38 dependent signalling as a major intermediate filament regulating pathway . Regulation KRT38 HOXC13 11714694 904058 is *involved* in the regulation of human hair [keratin] gene expression . Regulation KRT38 HOXC13 11714694 904108 Collectively , our data speak for a direct *involvement* of in the control of hair [keratin] expression during early trichocyte differentiation . Regulation KRT38 HOXC13 16292560 1510763 We previously showed that the homeodomain protein is *involved* in the expression control of the early human hair [keratin] genes hHa5 and hHa2 , which contain specific HOXC13 binding sites in their proximal promoters . Regulation KRT38 HOXC13 22583695 2686804 Among these , is also *involved* in the expression control of the human [keratin] genes hHa5 and hHa2 , and recently it was identified as a member of human DNA replication complexes . Regulation KRT38 IFNG 1372562 183161 *regulates* expression of a novel [keratin] class I gene . Regulation KRT38 IL6 17213200 1702778 Caco2-BBE cell line and IL-6 null mice were used to study the *effect* of on [keratin] expression . Regulation KRT38 KLF6 12407152 1010232 This study was conducted to investigate the possible involvement of Krüppel-like factor 6 (KLF6) in the corneal regulation of K12 gene expression , in view of the presence of one KLF6 potential binding site in the human K12 promoter and the known *role* of in regulating [keratin] gene expression . Regulation KRT38 KRT18 9524113 494362 Comparison of wild-type versus K18 Ser33 -- > Ala/Asp transfected cells showed that Ser33 phosphorylation is essential for the association of K18 with 14-3-3 proteins , and *plays* a role in [keratin] organization and distribution . Regulation KRT38 LEF1 14610062 1162710 In contrast , Lef1 is up-regulated , but its regulated control of hair differentiation is still blocked , and BMPRIA-null follicles fail to activate *regulated* genes , including [keratin] genes . Regulation KRT38 MYLIP 20522784 2320086 Microarray , qRT-PCR and Western blot analyses revealed that negatively *regulates* expression of Fgf10 , the components of Wnt and BMP signaling pathways Sclerostin and BAMBI , and Dlx3 transcription factor , as well as selected [keratin] genes , both in vitro and in vivo . Regulation KRT38 PLEC 19419971 2096031 isoform dependent *regulation* of [keratin-integrin] alpha6beta4 anchorage via Ca2+/calmodulin . Regulation KRT38 PRL 20103718 2265039 Here , we have investigated the *effects* of the neurohormone on [keratin] expression in a physiologically and clinically relevant test system : organ cultured normal human hair follicles ( HFs ) . Regulation KRT38 SP1 9154804 431449 *Regulation* of K3 [keratin] gene transcription by and AP-2 in differentiating rabbit corneal epithelial cells . Regulation KRT38 TFAP2A 1722450 173450 This paper identifies a new , developmental *role* for transcription factor in the activation of amphibian embryonic epidermal [keratin] gene expression . Regulation KRT38 TFAP2A 1722450 173600 Thus , the study of and its *role* in the regulation of [keratin] gene transcription should enhance our understanding of both amphibian embryonic development and mammalian skin differentiation . Regulation KRT38 TFAP2A 9154804 431450 *Regulation* of K3 [keratin] gene transcription by Sp1 and in differentiating rabbit corneal epithelial cells . Regulation KRT38 TGFB1 7537080 300822 We have recently shown that epidermal growth factor (EGF) and ( TGF beta ) , modulators of keratinocyte proliferation , *regulate* expression of specific [keratin] genes . Regulation KRT38 TGFB2 7537080 300823 We have recently shown that epidermal growth factor (EGF) and ( TGF beta ) , modulators of keratinocyte proliferation , *regulate* expression of specific [keratin] genes . Regulation KRT38 TGFB3 7537080 300824 We have recently shown that epidermal growth factor (EGF) and ( TGF beta ) , modulators of keratinocyte proliferation , *regulate* expression of specific [keratin] genes . Regulation KRT38 TRH 23373458 2803707 Preliminary evidence had suggested that may *regulate* [keratin] gene transcription . Regulation KSR1 MAP2K6 15084597 1258001 The kinase activity of [kinase suppressor of Ras1 (KSR1)] is *independent* of bound . Regulation LACRT TGM2 23769845 2870600 Levels of active monomeric [lacritin] are negatively *regulated* by tear , whose expression is elevated in dry eye with ocular surface inflammation . Regulation LAD1 TNFSF10 24431305 2884288 The article briefly describes controversies in type 1 diabetes ( T1DM ) pathogenesis and diagnosis ( genetic background , accelerator hypothesis , new autoantibodies , new information on [LADA] - latent autoimmune diabetes in adults , and the *role* of - tumor necrosis factor related apoptosis inducing ligand ) and treatment ( how to deal with fluctuations of blood glucose concentrations and the occurrence of hypoglycemia , the role of healthy lifestyle , especially physical exercise , and a proper diet , treatment of insulin resistance and the challenges in detecting diabetic neuropathy ) . Regulation LAMA4 PRKDC 11448237 835690 We present evidence that transcription of the extracellular matrix gene [laminin alpha 4 (Lama4)] is *regulated* by in a radiation independent manner . Regulation LAMA4 XRCC5 11448237 835688 We present evidence that transcription of the extracellular matrix gene [laminin alpha 4 (Lama4)] is *regulated* by in a radiation independent manner . Regulation LAMA4 XRCC6 11448237 835689 We present evidence that transcription of the extracellular matrix gene [laminin alpha 4 (Lama4)] is *regulated* by in a radiation independent manner . Regulation LAMA5 MMP7 17145868 1653901 By searching the ligands of MMP7 in the colonic carcinoma cells HT29 , we identified [laminin-5/laminin-332 (LN5)] as a specific *target* for enzymatic activity . Regulation LAMB2 MMP7 17145868 1653902 By searching the ligands of MMP7 in the colonic carcinoma cells HT29 , we identified [laminin-5/laminin-332 (LN5)] as a specific *target* for enzymatic activity . Regulation LAMB3 KNTC1 11139649 758903 Three candidate models were quantitatively optimized to the Murnick & [Lamb] saturated toad flash *responses* and , simultaneously , to a set of sub saturated flash responses . Regulation LAMB3 MYLIP 23159910 2707550 Furthermore , we focused on LAMB3 which has a miR-218 target site and gene expression studies and luciferase reporter assays showed that [LAMB3] was directly *regulated* by . Regulation LAMB3 SETD2 18713836 1955634 In this context , we demonstrate that *controls* the expression of [laminin-332] , one of the major epithelial cell adhesion ligands involved in cell migration and invasion . Regulation LAMB3 TCF12 18713836 1955608 HIF1 *regulates* [laminin-332] expression and keratinocyte migration . Regulation LAMB3 TCF15 18713836 1955609 HIF1 *regulates* [laminin-332] expression and keratinocyte migration . Regulation LAMB3 TCF19 18713836 1955610 HIF1 *regulates* [laminin-332] expression and keratinocyte migration . Regulation LAMB3 TCF20 18713836 1955611 HIF1 *regulates* [laminin-332] expression and keratinocyte migration . Regulation LAMB3 TCF21 18713836 1955612 HIF1 *regulates* [laminin-332] expression and keratinocyte migration . Regulation LAMB3 TCF23 18713836 1955616 HIF1 *regulates* [laminin-332] expression and keratinocyte migration . Regulation LAMB3 TCF24 18713836 1955618 HIF1 *regulates* [laminin-332] expression and keratinocyte migration . Regulation LAMB3 TCF25 18713836 1955617 HIF1 *regulates* [laminin-332] expression and keratinocyte migration . Regulation LAMB3 TCF3 18713836 1955613 HIF1 *regulates* [laminin-332] expression and keratinocyte migration . Regulation LAMB3 TCF4 18713836 1955614 HIF1 *regulates* [laminin-332] expression and keratinocyte migration . Regulation LAMB3 TCF7 18713836 1955615 HIF1 *regulates* [laminin-332] expression and keratinocyte migration . Regulation LAMB3 TGFB1 20844080 2336815 Autocrine activation mediated by integrin {alpha}V{beta}3 *regulates* transcriptional expression of [laminin-332] in Madin-Darby canine kidney epithelial cells . Regulation LAMB3 ZEB1 20729552 2335775 coordinately *regulates* [laminin-332] and { beta } 4 integrin expression altering the invasive phenotype of prostate cancer cells . Regulation LAMC2 TNF 20307265 2238078 Loss of Smad4 may lead to uncoupled induction of [laminin-gamma2] in *response* to and may therefore represent one of the mechanisms which underlie accumulation of laminin-gamma2 at the invasive margin of a tumor . Regulation LAMC3 MMP7 17145868 1653903 By searching the ligands of MMP7 in the colonic carcinoma cells HT29 , we identified [laminin-5/laminin-332 (LN5)] as a specific *target* for enzymatic activity . Regulation LANCL1 TLR7 17981792 1845630 In addition to pDC , conventional dendritic cell ( cDC ) also produced IL-12p40 in response to poly ( A : U ) . This [IL-12p40] induction resulted from two cDC subsets , CD24 ( high ) cDC and CD11b ( high ) cDC in a TLR3- and *dependent* manner , respectively . Regulation LANCL1 TLR7 23750720 2834129 In contrast to humans , pDC in rhesus macaques expressed the interleukin [(IL)-12p40] subunit in *response* to as well as TLR-9 stimulation . Regulation LAT MAP2K6 10779414 687432 The TCR induced increase in [LAT] expression *involved* the activation of the serine/threonine kinases PKC and , because inhibitors of these kinases blocked the increase in LAT . Regulation LBP ALB 12372833 1019650 Incubation of LOS ( agg ) with LBP and sCD14 promoted LOS ( agg ) disaggregation in an *dependent* fashion to complexes that contain LOS and sCD14 , but no [LBP] , with an apparent M ( r ) approximately 60,000 ( LOS : sCD14 ) as determined by Sephacryl S200 chromatography . Regulation LBP APOA1 9101432 423021 These results suggested that is a key component in the association of LBP with HDL and may *play* an important role in the biologic activity of [LPS/LBP] complexes . Regulation LBP CALML3 22040879 2503581 Taken together , the results suggested that 's inhibitory *effect* on [LPS-LBP] binding and on the subsequent MAPK pathway signaling may be responsible for its anti-LPS mechanism . Regulation LBP CD14 9169763 432888 Binding to monocytes was enhanced by human pooled serum (HPS) or [LPS binding protein (LBP)] for LPS concentrations up to 100 ng/ml and was completely *dependent* . Regulation LBP FGB 10607703 655920 To determine whether *affects* the lipid transfer activity of [LBP] on FALP , this activity was measured in FALP prepared with and without fibrinogen . Regulation LBP FGB 10607703 655921 Neither activity of [LBP] was *affected* by . Regulation LBP IL1A 10919979 717299 These cells produced [LBP] in *response* to , IL-6 , and tumor necrosis factor- alpha , a response that was strongly enhanced by dexamethasone . Regulation LBP IL6 10919979 717300 These cells produced [LBP] in *response* to interleukin (IL)-1beta , , and tumor necrosis factor- alpha , a response that was strongly enhanced by dexamethasone . Regulation LBP MAPK1 23194012 2752032 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Regulation LBP MAPK1 23194012 2752058 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Regulation LBP MAPK10 23194012 2752033 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Regulation LBP MAPK10 23194012 2752059 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Regulation LBP MAPK11 23194012 2752034 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Regulation LBP MAPK11 23194012 2752060 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Regulation LBP MAPK12 23194012 2752035 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Regulation LBP MAPK12 23194012 2752061 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Regulation LBP MAPK13 23194012 2752036 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Regulation LBP MAPK13 23194012 2752062 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Regulation LBP MAPK14 23194012 2752037 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Regulation LBP MAPK14 23194012 2752063 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Regulation LBP MAPK15 23194012 2752031 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Regulation LBP MAPK15 23194012 2752057 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Regulation LBP MAPK3 23194012 2752038 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Regulation LBP MAPK3 23194012 2752064 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Regulation LBP MAPK4 23194012 2752039 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Regulation LBP MAPK4 23194012 2752065 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Regulation LBP MAPK6 23194012 2752040 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Regulation LBP MAPK6 23194012 2752066 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Regulation LBP MAPK7 23194012 2752041 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Regulation LBP MAPK7 23194012 2752067 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Regulation LBP MAPK8 23194012 2752042 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Regulation LBP MAPK8 23194012 2752068 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Regulation LBP MAPK9 23194012 2752043 Nuclear factor-?B and p38 signaling pathways are critically *involved* in Porphyromonas gingivalis lipopolysaccharide induction of [lipopolysaccharide binding protein] expression in human oral keratinocytes . Regulation LBP MAPK9 23194012 2752069 This study demonstrates that NF-?B and p38 signaling pathways are *involved* in P. gingivalis LPS ( 1690 ) induction of [LBP] expression in HOKs . Regulation LBP TNF 15082348 1234281 This study investigates whether ( TNF-alpha ) might be *responsible* for the [LBP] formation during endogenous endotoxemia postburn . Regulation LCN2 CAPN8 19830249 2149113 The kinase is typically activated by [p25] , derived from p35 by calpain mediated cleavage , but inhibition of does not *affect* cell death or the activation of Cdk5 . Regulation LCN2 TNF 21403867 2361400 Both IL-1ß and *regulate* [NGAL] expression in polymorphonuclear granulocytes of chronic hemodialysis patients . Regulation LCP1 CAPN8 20183869 2236836 Characterization of [L-plastin] interaction with beta integrin and its *regulation* by . Regulation LDHA TNF 10385397 625425 These observations suggest that the stimulatory *effect* of on [LDH A] mRNA expression requires protein synthesis and may involve a protein tyrosine kinase and protein kinase C . Regulation LDHA TNF 11058554 746205 Role of sphingosine in the alpha stimulatory *effect* on [lactate dehydrogenase A] expression and activity in porcine Sertoli cells . Regulation LDHA TNF 11058554 746206 Together , the present data suggest that in primary Sertoli cell cultures , stimulating *action* on [LDHA] expression is partly exerted via sphingomyelin hydrolysis pathway , sphingosine being the active metabolite . Regulation LDLR EPHB2 16100034 1460834 Using different reporter constructs , we demonstrate that BBR affects [LDLR] mRNA stability entirely through 3 ' untranslated region ( UTR ) in an *dependent* manner , and this stabilizing effect is more prominent in liver derived cells than nonhepatic cell lines . Regulation LDLR IL1B 9624172 511404 These results show that or TNF induced LDL receptor expression requires ERK-1/2 activation , that the p38 ( MAPK ) pathway negatively *regulates* [LDL receptor] expression , and that sterols inhibit induction at a point downstream of ERK-1/2 in HepG2 cells . Regulation LDLR IL1B 9641167 514126 We explored the *effects* of 50 ng/ml of tumour necrosis factor alpha (TNF alpha) , 5 ng/ml of transforming growth factor beta ( TGF beta ) , platelet derived growth factor ( PDGF ) , and on the regulation of [LDLr] gene transcription in a human mesangial cell line ( HMCL ) using cell proliferation , LDL binding , northern blot and LDLr promoter activity assays . Regulation LDLR PCSK9 15118091 1244592 Furthermore , whereas overexpression of had no *effect* on [LDLR] mRNA levels , there was a near absence of LDLR protein in animals overexpressing Pcsk9 . Regulation LDLR PCSK9 15767856 1384243 The cellular role for PCSK9 and the mechanism behind its mutations are under study , and a *role* for in regulating [LDL receptor] protein levels has been demonstrated . Regulation LDLR PCSK9 17328821 1706673 However , it is unknown whether *acts* directly on the [LDLR] or if PCSK9 activates another protein that in turn causes degradation of the LDLR . Regulation LDLR PCSK9 17493938 1766635 Effects of pH and low density lipoprotein (LDL) on dependent [LDL receptor] *regulation* . Regulation LDLR PCSK9 18052825 1889367 Genetic and cell biology studies have suggested a critical *role* of in regulating [low-density lipoprotein receptor (LDLR)] protein levels and thus modulating plasma LDL cholesterol . Regulation LDLR PCSK9 18054775 1861155 These observations suggest an *involvement* of in hepatic [LDL receptor] protein degradation and perhaps , in increasing the rate of LDL receptor cycling resulting in lower serum cholesterol levels in response to cholesterol biosynthesis inhibitors . Regulation LDLR PCSK9 19060325 2099854 The *regulation* of [LDLR] by displayed tissue specificity , with liver being the most responsive tissue . Regulation LDLR PCSK9 19060325 2099856 Our data also suggest that [LDLR] protein *regulation* by has tissue specificity , with liver being the most responsive tissue . Regulation LDLR PCSK9 19635789 2143050 Although the mechanism by which *regulates* [LDLR] degradation is not fully resolved , it seems to involve both intracellular and extracellular pathways . Regulation LDLR PCSK9 19828345 2202982 These studies were performed in CHO T-REx cells stably transfected with a plasmid encoding the chimeric receptor and a novel assay was developed to study the *effect* of on the [LDLR] in these cells . Regulation LDLR PCSK9 21518694 2439595 [LDLR] *regulation* by has not been extensively described during mouse brain development and injury . Regulation LDLR PCSK9 22176652 2543130 released from SMCs directly *regulated* [LDLR] expression in macrophages as demonstrated by retroviral overexpression or knockdown of PCSK9 with small interfering RNA and by using recombinant PCSK9 . Regulation LDLR PCSK9 22492369 2583578 Proprotein convertase subtilisin/kexin type-9 ( , a hepatic [LDL-receptor] *regulator* ) , inflammation , and adipose tissue expression of inflammatory and lipogenic genes were determined . Regulation LDLR PCSK9 23115612 2695876 However , hints in the literature indicate that intracellular may *act* on the [LDLR] , possibly during processing of newly synthesized protein . Regulation LDLR PCSK9 23221398 2731347 is *involved* in the degradation of [LDLR] and VLDLR . Regulation LDLR PCSK9 23690465 2801371 Our results support a scenario in which [LDLR] represents the main route of elimination of PCSK9 and a reciprocal regulation between these 2 proteins *controls* serum levels , hepatic LDLR expression , and serum LDL levels . Regulation LDLR TNF 2244888 145857 *Effect* of on the activity of the [low density lipoprotein receptor] on human skin fibroblasts . Regulation LDLR TNF 8387950 218074 In this study , the *effect* of on [low-density lipoprotein receptor] activity was investigated in cells of HepG2 , a well differentiated human hepatoma cell line . Regulation LDLR TNF 9624172 511403 These results show that IL-1beta- or induced LDL receptor expression requires ERK-1/2 activation , that the p38 ( MAPK ) pathway negatively *regulates* [LDL receptor] expression , and that sterols inhibit induction at a point downstream of ERK-1/2 in HepG2 cells . Regulation LEF1 AXIN2 10428961 633448 To understand the mechanism by which Dvl acts through GSK to regulate LEF-1 , we investigated the *roles* of and Frat1 in Wnt mediated activation of [LEF-1] in mammalian cells . Regulation LEFTY1 EPHB2 22441145 2612792 Transforming growth factor ß and signaling *regulate* the expression level of a novel tumor suppressor [Lefty] . Regulation LEFTY1 EPHB2 22441145 2612814 The objectives of the present study were ( i ) to identify a novel tumor suppressor gene whose expression level was regulated by transforming growth factor ( TGF-ß ) and ( ii ) to evaluate the *effect* of signaling on TGF-ß dependent [Lefty] up-regulation . Regulation LEFTY1 MAP2K6 22441145 2612800 Transforming growth factor ß and signaling *regulate* the expression level of a novel tumor suppressor [Lefty] . Regulation LEFTY1 MAP2K6 22441145 2612822 The objectives of the present study were ( i ) to identify a novel tumor suppressor gene whose expression level was regulated by transforming growth factor ( TGF-ß ) and ( ii ) to evaluate the *effect* of signaling on TGF-ß dependent [Lefty] up-regulation . Regulation LEFTY2 EPHB2 22441145 2612781 Transforming growth factor ß and signaling *regulate* the expression level of a novel tumor suppressor [Lefty] . Regulation LEFTY2 EPHB2 22441145 2612803 The objectives of the present study were ( i ) to identify a novel tumor suppressor gene whose expression level was regulated by transforming growth factor ( TGF-ß ) and ( ii ) to evaluate the *effect* of signaling on TGF-ß dependent [Lefty] up-regulation . Regulation LEFTY2 MAP2K6 22441145 2612789 Transforming growth factor ß and signaling *regulate* the expression level of a novel tumor suppressor [Lefty] . Regulation LEFTY2 MAP2K6 22441145 2612811 The objectives of the present study were ( i ) to identify a novel tumor suppressor gene whose expression level was regulated by transforming growth factor ( TGF-ß ) and ( ii ) to evaluate the *effect* of signaling on TGF-ß dependent [Lefty] up-regulation . Regulation LEO1 ALOX5 3152458 104203 This suggests that <5-lipoxygenase> *dependent* mediators and [PAF] are involved in allergic contact dermatitis and that these mediators play only a minor role in irritant dermatitis . Regulation LEO1 ALOX5 7488299 323023 This study has examined the *effects* of a new <5-lipoxygenase> inhibitor , 6-hydroxy-2- ( 4-sulfamoylbenzylamino ) -4,5,7-trimethylbenzothiazo le hydrochloride ( CAS 120164-49-0 , E6080 ) on the release of LTC4 , LTB4 and [PAF] by human eosinophils , Eosinophils stimulated by 1 mumol/l calcium ionophore A23187 for 15 min released 37.5 +/- 2.2 ng , 2.3 +/- 0.3 ng and 4.0 +/- 0.3 pmol per 10 ( 6 ) cells of immunoreactive LTC4 , LTB4 and PAF , respectively ( mean +/- SEM , n = 4 ) . Regulation LEO1 ARSA 8107285 246012 Next , synthesized PAF from washed platelets or washed leukocytes stimulated with collagen or ONO-11113 ( STA2 ; stable analogue of thromboxane A2 ) , and the inhibiting *effects* of on the [PAF] synthesis from collagen stimulated leukocytes were examined , using a radioimmunoassay kit for PAF . Regulation LEO1 EDN2 2051719 161782 The purpose of the present series of experiments has been to analyze the functional relations between the *effect* of on renal function and glomerular and mesangial cell contraction and the production and actions of [PAF] in kidney . Regulation LEO1 F2R 10395981 627776 The *effect* of a agonist peptide ( TRAP-6 ) on the release of nitric oxide ( NO ) and [platelet activating factor (PAF)] from resting and calcium-ionophore ( A23187 ) -activated rat peritoneal mast cells ( RPMC ) was studied using a platelet aggregation bioassay . Regulation LEO1 TNF 1499148 193558 4. Furthermore , we investigated the priming *effect* of recombinant human , which is known to be one of the most important mediators in the development of ARDS , on [PAF] production induced by the calcium ionophore in neutrophils . Regulation LEO1 TNF 1846897 153389 We have further examined the *effects* of on arachidonic acid ( AA ) release , LTB4 production , and [platelet activating factor (PAF)] formation in PMN by prelabeling cells with either [ 3H ] AA or [ 3H ] lyso-PAF , priming with human rTNF-alpha , and then stimulating with the chemotactic peptide , FMLP . Regulation LEO1 TNF 3119758 80244 Synthesis of [PAF] in *response* to was also detected in rat polymorphonuclear neutrophils , but not in human tumor cells and dermal fibroblasts . Regulation LEO1 TNF 3261295 96004 About 30 % of [PAF] produced in *response* to either or IL-1 is released into the medium , whereas approximately 70 % remains cell associated . Regulation LEO1 TNF 3261295 96015 Experiments with labeled precursors show that [PAF] is synthesized de novo in *response* to . Regulation LEO1 TNF 3261295 96026 This suggests that [PAF] is synthesized by the same pathway in *response* to or IL-1 . Regulation LEO1 TNF 8488366 219201 In contrast to its effect on the AA turnover , did not *affect* the phospholipase C-stimulated production of platelet activating factor ( [PAF-acether] ) . Regulation LEO1 TNF 9187959 437090 GM-CSF production by EC was also stimulated by the combined effects of PAF and , but [PAF] alone did not *affect* GM-CSF production . Regulation LEP CA12 15449734 1300630 The *effect* of inhibition on [leptin] secretion by rat adipose tissue . Regulation LEP EPHB2 15319373 1303763 Further , the PI-3 kinase inhibitor LY294002 and MAPK inhibitor PD98059 were found to significantly reduce leptin induced HSC proliferation , thereby indicating that [leptin] induced HSC proliferation is Akt- and *dependent* . Regulation LEP EPHB2 23224631 2736607 Amylin induced downregulation of hippocampal neurogenesis is attenuated by [leptin] in a *dependent* manner in mice . Regulation LEP IL1B 11822823 892908 We also determined the regulatory *effects* of on leptin secretion and on the expression of [leptin] and leptin receptor at the protein level in both EEC and endometrial stromal cell ( ESC ) cultures . Regulation LEP IL1B 12468269 1022550 further enhanced PGE ( 2 ) formation by adipocytes but did not *affect* [leptin] formation . Regulation LEP IL1B 20506629 2263992 *regulates* metalloproteinase activity and [leptin] secretion in a cytotrophoblast model . Regulation LEP IL1B 20506629 2263993 Here we investigated the *effect* of on the activity of two important metalloproteinases ( MMP-2 and MMP-9 ) that are involved in extracellular matrix remodeling as well as the secretion of [leptin] , one of the reproductive hormones actively regulating their activity and secretion . Regulation LEP IL1B 9458919 484660 To investigate the *role* of and IL-6 in [leptin] expression during inflammation , we used IL-1 beta-deficient ( -/- ) and IL-6 -/- mice . Regulation LEP TNF 10490793 645629 at concentrations of 0.024 , 0.24 , 2.4 and 24 ng/ml did not *affect* [leptin] secretion over 24 h . TNF-alpha at concentrations of 0.24 to 24 ng/ml significantly inhibited leptin secretion over 96 h by 19-60 % . Regulation LEP TNF 10490793 645630 at a concentration of 0.024 ng/ml did not *affect* [leptin] secretion , glucose uptake or lactate production . Regulation LEP TNF 10526261 654183 The aim of this study was to characterize the *role* of and transforming growth factor (TGF)-beta1 in depot-specific secretion of [leptin] from cultured human adipocytes . Regulation LEP TNF 10526261 654185 We measured the leptin concentrations in the culture medium of omental and subcutaneous abdominal adipocytes taken from severely obese individuals and kept in suspension culture , and studied the *effect* of and TGF-beta1 on [leptin] release . Regulation LEP TNF 10687854 669925 The acute and chronic *effects* of on [leptin] production by human preadipocytes , differentiated preadipocytes , and mature adipocytes have been examined by competitive RT-PCR of leptin mRNA and by western blotting . Regulation LEP TNF 10690850 670427 P < 0.05 ) was detected by 24 h . ( 10 ng/mL ) had no *effect* on dexamethasone ( 0.1 micromol/L ) -stimulated [leptin] production in sc adipocytes . Regulation LEP TNF 10690850 670430 The data suggest that the direct paracrine *effect* of adipose derived is inhibition of [leptin] production . Regulation LEP TNF 11758007 887626 The expression of [leptin] , an adipocyte derived protein , is *regulated* by . Regulation LEP TNF 12200753 982943 These results suggest that TNF-alpha induced hyperinsulinemia likely mediates the stimulatory *effect* of on circulating [leptin] in vivo . Regulation LEP TNF 15784704 1410092 The *regulation* of [leptin] by is poorly understood in CD . Regulation LEP TNF 15784704 1410094 Pharmacological neutralization of TNFalpha with infliximab offers a unique opportunity to study mediated *regulation* of [leptin] in CD patients . Regulation LEP TNF 16403817 1540107 The objective of this study was to determine the *effect* of on [leptin] release from human adipose tissue ( AT ) from healthy subjects undergoing elective surgery or needle aspirations of AT at a university hospital . Regulation LEP TNF 16403817 1540150 Synergistic *effects* of increased local or systemic in combination with glucocorticoids may contribute to increased [leptin] expression in response to stress , including infection and obesity . Regulation LEP TNF 20576518 2285477 We have associated functional and molecular studies of insulin and leptin to investigate the *effect* of on central insulin and [leptin] signaling in rats pre treated with PTP1B-ASO . Regulation LEP TNF 9564834 500792 In vivo and in vitro evidence for the *involvement* of in the induction of [leptin] by lipopolysaccharide . Regulation LEP TNF 9564834 500795 To examine the *role* of in mediating [leptin] secretion during an immunological challenge , we studied the effects of lipopolysaccharide (LPS) and TNF alpha on leptin secretion in endotoxin-sensitive C3H/HeOuJ ( OuJ ) mice , endotoxin-insensitive C3H/HeJ ( HeJ ) mice , and primary adipocytes cultured from both . Regulation LEPR CLU 23673647 2785259 In *response* to , the low-density lipoprotein receptor related protein-2 binding to long-form [leptin receptor] is greatly enhanced in cultured neuronal cells . Regulation LEPR EPHB2 21726645 2461364 Consistent with this possibility , exposure of hypothalamic cells to zinc activated Erk-1/2 and induced [Lepr] expression in an *dependent* manner . Regulation LEPR IL1B 11822823 892909 We also determined the regulatory *effects* of on leptin secretion and on the expression of leptin and [leptin receptor] at the protein level in both EEC and endometrial stromal cell ( ESC ) cultures . Regulation LEPR TNF 23070544 2703395 We investigated a possible *role* of , a key early mediator of inflammation , in regulating the expression and trafficking of the long-isoform [leptin receptor] ( LEPRb ) , the primary mediator of leptin signaling , in cultured cells . Regulation LGALS7B JDP2 23530091 2762258 [Galectin-7] accumulation was mediated through JNK inhibition presumably resulting from the observed induction of p53 , and was negatively *regulated* by the AP-1 inhibitor . Regulation LGALS9 IL1B 11726788 884502 We conclude that astrocytes produce [galectin-9] in *response* to the stimulation with , and this may contribute to inflammatory reactions in the CNS . Regulation LGALS9 TLR7 23967307 2832771 In this study , our data suggest that Tim-3 and IL-12/IL-23 gene transcriptions are *regulated* by enhanced or silenced [Gal-9] expression within monocytes through synergizing with signaling . Regulation LGMN CST6 19262604 2072724 directly *controls* the activity of cathepsin V , cathepsin L , and [legumain] , thereby regulating the processing of transglutaminases . Regulation LGMN CST6 20074384 2205644 These results suggest that the level of *regulates* [legumain] activity and hence the invasive potential of human melanoma cells . Regulation LGMN CST6 20495178 2319866 Biochemical evidence suggests that *controls* the activity of [legumain] , cathepsin L , cathepsin V , and transglutaminase-3 . Regulation LGMN CST6 22902879 2687711 Furthermore , auto-activation of secreted prolegumain was inhibited by cystatin E/M , which for the first time shows a regulatory *role* of in controlling both intra- and extracellular [legumain] activity . Regulation LGR4 CD14 23589304 2789523 [Lgr4/Gpr48] negatively *regulates* TLR2/4 associated pattern recognition and innate immunity by targeting expression . Regulation LHB FOXO1 22865884 2677416 We also showed that FOXO1 repressed basal transcription and gonadotropin releasing hormone (GnRH) induction of both the murine and human LHB genes in LßT2 cells , suggesting that *regulation* of [LHB] transcription may be conserved between rodents and humans . Regulation LHCGR FOXO1 23754802 2820134 [Lhcgr] expression in granulosa cells : *roles* for PKA phosphorylated ß-catenin , TCF3 , and . Regulation LHX2 PLAU 23864708 2835155 *regulates* [Lhx2] expression by suppressing expression of miR-124 and p53 expression by repressing its promoter by inactivating HOXA5 . Regulation LHX4 SP1 18053794 1846673 We conclude directly *regulates* [Lhx4] gene expression . Regulation LHX4 TGFB3 16456677 1561343 Our data suggest that the L3/Lhx8 gene contributes to epithelial mesenchymal interaction in facial morphogenesis and that Fgf-8b and were , at least in part , *responsible* for the [Lhx] expression in the maxillary process . Regulation LIF EPHB2 10217263 608363 These results indicate that [LIF] mRNA levels can be *regulated* by activation via stimulation of PKC in Schwann cells . Regulation LIF FAS 20926603 2375722 Caspases were activated upon Fas-stimulation and the mediated *effects* on [LIF] , IL-11 and -8 were reversed by caspase-inhibition . Regulation LIF IL1B 8913777 395634 We characterized the molecular mechanism of [LIF] mRNA *regulation* by in explanted neonatal rat SCG and a Schwann cell line . Regulation LIF IL1B 9564823 500750 This *effect* of on [LIF] mRNA expression was abolished by preincubation with human IL-1 receptor antagonist ( 100 ng/ml ) or antimurine IL-1beta antibody ( 10 microg/ml ) . Regulation LIF IL6R 9110148 425014 with two mutated gp130 binding sites did not *affect* IL-11 , CNTF , [LIF] or OM activities . Regulation LIF TNF 8666813 369119 In addition , to assess the *role* of in the induction of [LIF] in vivo , seven baboons were studied that had either received a bolus injection of recombinant human TNF-alpha ( 100 micrograms/kg , n=3 ) , or to whom 15 mg/kg of an anti-TNF mAB before lethal E. coli challenge was administered ( n=4 ) . Regulation LIFR CEACAM6 22905257 2648202 The JAK1 redox switch is likely not a target of acyloxy nitroso compounds , as had no effect on JAK1 catalytic activity and only modestly *affected* JAK1 induced phosphorylation of the [LIF receptor] . Regulation LILRA3 TNF 20595277 2296417 Soluble [LILRA3] , a potential natural antiinflammatory protein , is increased in patients with rheumatoid arthritis and is tightly *regulated* by interleukin 10 , , and interferon-gamma . Regulation LILRA5 JAG1 11034379 740693 [CD85/LIR-1/ILT2] also *controls* responses to recall and , in low responders , its engagement sharply increases T cell proliferation . Regulation LILRB1 JAG1 11034379 740694 [CD85/LIR-1/ILT2] also *controls* responses to recall and , in low responders , its engagement sharply increases T cell proliferation . Regulation LILRB2 TLR7 19860908 2160605 In addition to the high level expression that can render antigen presenting cells tolerogenic , there may be a role for lower level expression and activity of [LILRB2] and LILRB4 in *response* to signalling during an immune response to bacterial infection . Regulation LILRB4 TLR7 19860908 2160615 In addition to the high level expression that can render antigen presenting cells tolerogenic , there may be a role for lower level expression and activity of LILRB2 and [LILRB4] in *response* to signalling during an immune response to bacterial infection . Regulation LIN37 AXIN2 21814488 2462859 Third , [Ppa-LIN-18/Ryk] signaling *involves* and ß-catenin and Ppa-axl-1/Axin is epistatic to Ppa-lin-18/Ryk . Regulation LIN52 AXIN2 21814488 2462851 Third , [Ppa-LIN-18/Ryk] signaling *involves* and ß-catenin and Ppa-axl-1/Axin is epistatic to Ppa-lin-18/Ryk . Regulation LIN54 AXIN2 21814488 2462853 Third , [Ppa-LIN-18/Ryk] signaling *involves* and ß-catenin and Ppa-axl-1/Axin is epistatic to Ppa-lin-18/Ryk . Regulation LIN9 AXIN2 21814488 2462857 Third , [Ppa-LIN-18/Ryk] signaling *involves* and ß-catenin and Ppa-axl-1/Axin is epistatic to Ppa-lin-18/Ryk . Regulation LINC00284 SUN1 21966565 2488481 Besides that , we observed that expression of individual Sun1 isoforms remarkably depends on the cell type , suggesting a cell type-specific adaption of *dependent* [LINC] complexes to specific cellular and physiological requirements . Regulation LINC00284 TP53 19383908 2068597 Here , we show that DNA damage results in the *dependent* binding of p130 and E2F4 to [LINC] and the dissociation of B-MYB from LINC . Regulation LINC00341 SUN1 21966565 2488441 Besides that , we observed that expression of individual Sun1 isoforms remarkably depends on the cell type , suggesting a cell type-specific adaption of *dependent* [LINC] complexes to specific cellular and physiological requirements . Regulation LINC00341 TP53 19383908 2068557 Here , we show that DNA damage results in the *dependent* binding of p130 and E2F4 to [LINC] and the dissociation of B-MYB from LINC . Regulation LIPE TNF 22949029 2693379 did not *affect* perilipin , [HSL] , or phosphodiesterase-3B mass but paradoxically suppressed adipose tissue triglyceride lipase expression , and this effect was blocked by DEX . Regulation LIPE TNF 2332411 132598 Inhibitory *effect* of on gene expression of [hormone sensitive lipase] in 3T3-L1 adipocytes . Regulation LIPE TNF 8194485 258884 The *effect* of on the expression of [hormone-sensitive lipase] ( HSL ; the rate limiting enzyme for lipolysis ) was investigated by Western immunoblots using an antibody raised to a bacterially expressed 96-amino acid portion of the HSL enzyme . Regulation LIPG MSH2 2160650 133359 peptide , administered from day of birth to postnatal day 13 , had no *effect* on [EDL] muscle metabolic activity using the 2,3,5-triphenyltetrazolium chloride indicator . Regulation LIPG MSH3 2160650 133360 peptide , administered from day of birth to postnatal day 13 , had no *effect* on [EDL] muscle metabolic activity using the 2,3,5-triphenyltetrazolium chloride indicator . Regulation LIPG MSH4 2160650 133361 peptide , administered from day of birth to postnatal day 13 , had no *effect* on [EDL] muscle metabolic activity using the 2,3,5-triphenyltetrazolium chloride indicator . Regulation LIPG MSH5 2160650 133362 peptide , administered from day of birth to postnatal day 13 , had no *effect* on [EDL] muscle metabolic activity using the 2,3,5-triphenyltetrazolium chloride indicator . Regulation LIPG MSH6 2160650 133363 peptide , administered from day of birth to postnatal day 13 , had no *effect* on [EDL] muscle metabolic activity using the 2,3,5-triphenyltetrazolium chloride indicator . Regulation LIPG SCARB1 19136670 2037748 [Endothelial lipase (EL)] is a negative regulator of high density lipoprotein ( HDL ) cholesterol plasma levels , and is *involved* in remodeling of HDL . Regulation LIPG VEGFA 23102786 2699153 *Regulation* of [endothelial lipase] and systemic HDL cholesterol levels by SREBPs and . Regulation LMNB1 IL1B 15201138 1288924 N ( G ) -monomethyl-l-arginine , a known inhibitor of inducible nitric oxide synthetase (iNOS) , markedly inhibited IL-1beta induced iNOS gene expression , NO release , caspase-3 and caspase-6 activation , lamin B degradation , and loss of metabolic cell viability , indicating that the observed induced *effects* on nuclear [lamin B] involve the intermediacy of NO . Regulation LMNB2 IL1B 15201138 1288925 N ( G ) -monomethyl-l-arginine , a known inhibitor of inducible nitric oxide synthetase (iNOS) , markedly inhibited IL-1beta induced iNOS gene expression , NO release , caspase-3 and caspase-6 activation , lamin B degradation , and loss of metabolic cell viability , indicating that the observed induced *effects* on nuclear [lamin B] involve the intermediacy of NO . Regulation LMO1 HOXB2 17676642 1788239 By analysing its expression in Hox knockout mice , we show that [Lmo1] is differentially *regulated* by Hoxa2 and , in specific columns of hindbrain neuronal progenitors . Regulation LMX1A FOXA1 19607821 2123922 Our studies show that and Foxa2 positively *regulate* [Lmx1a] and Lmx1b expression and inhibit Nkx2.2 expression in mesodiencephalic dopaminergic progenitors . Regulation LMX1B FOXA1 19607821 2123924 Our studies show that and Foxa2 positively *regulate* Lmx1a and [Lmx1b] expression and inhibit Nkx2.2 expression in mesodiencephalic dopaminergic progenitors . Regulation LMX1B WNT7A 15880584 1406205 These data suggest that acts through Lrp6 to *regulate* [Lmx1b] expression during dorsal specification . Regulation LOX IL1B 8872612 389700 Prostaglandin E2 , transforming growth factor-beta , and variably *regulate* the expression of cyclooxygenase 1 , cyclooxygenase 2 , and [lysyl oxidase] in IMR90 , human embryo lung fibroblasts . Regulation LOX PTGER2 9779823 540436 Role of receptors and cAMP in prostaglandin E2 *regulated* expression of type I collagen alpha1 , [lysyl oxidase] , and cyclooxygenase-1 genes in human embryo lung fibroblasts . Regulation LOX TNF 15138266 1267413 *Regulation* of collagen deposition and [lysyl oxidase] by in osteoblasts . Regulation LOX TNF 21893029 2486941 The higher dose *effect* on [LOX] expression was attenuated by the inhibition of PI3Kinase/Akt pathway . Regulation LPA EPHB2 15494214 1354861 The data indicate that ERK activation is essential for phenylephrine stimulation of NHE1 , and that and RhoA are *involved* in [LPA] stimulation of NHE1 by more than one mechanism . Regulation LPA EPHB2 15494214 1354873 These studies indicate a direct involvement of ERK in the alpha ( 1 ) -adrenergic activation of NHE1 and a significant *role* for both and RhoA in [LPA] stimulation of NHE1 in CCL39 fibroblasts . Regulation LPA LIPG 12164779 997646 To investigate the *effects* of on binding and uptake of high-density [lipoprotein] ( HDL ) , as well as on the selective uptake of HDL derived cholesterol esters (CEs) , HepG2 cells were infected with adenovirus coding for EDL . Regulation LPA LIPG 12909635 1150881 *Effects* of nonlipolytic ligand function of on high density [lipoprotein] metabolism in vivo . Regulation LPA LIPG 22972429 2706279 *regulates* plasma high-density [lipoprotein-cholesterol] ( HDL-C ) levels by promoting HDL catabolism . Regulation LPA PCSK9 15741654 1403109 Wild-type inhibits LDL clearance but does not *affect* apoB containing [lipoprotein] production in mouse and cultured cells . Regulation LPA PCSK9 23115612 2695875 The *role* of in the regulation of circulating low density [lipoprotein-cholesterol] ( LDL-c ) levels is ascribed to binding of circulating PCSK9 to the LDL receptor (LDLR) and subsequent lysosomal degradation of LDLR . Regulation LPA PLAU 18073130 1861920 [LPA] induces shedding of an 80-kDa E-cadherin-soluble fragment in an *dependent* manner and promotes in vitro invasion . Regulation LPA TNF 11735091 885667 Anthropometric measurements , fasting plasma glucose , insulin , [lipoprotein] concentrations , glucose , and insulin *responses* to OGTT , , and leptin concentrations were similar between the genotype at the -308 site both in hypertensive and normotensive groups . Regulation LPA TNF 19302817 2064275 DNA binding activity of NF-kappaB , a well-known molecular effector of TNFalpha , was moreover activated by [Lp(a)] in a *dependent* manner and the use of the NF-kappaB inhibitor Bay 11-7082 blocked Lp(a) triggered CCL1 induction . Regulation LPA TNF 8387950 218082 Preincubation of the cells with cycloheximide or actinomycin D totally abolished the up-regulatory *effect* of on low-density [lipoprotein] receptors . Regulation LPA TNF 9633941 513215 Dominant negative *effect* of TGF-beta1 and on basal and IL-6 induced lipoprotein(a) and [apolipoprotein(a)] mRNA expression in primary monkey hepatocyte cultures . Regulation LPCAT1 WNT1 23949154 2835979 Finally , DHT increased [LPCAT1] expression and PAF release in PC-3 cells in a *dependent* manner . Regulation LPCAT1 WNT11 23949154 2835980 Finally , DHT increased [LPCAT1] expression and PAF release in PC-3 cells in a *dependent* manner . Regulation LPCAT1 WNT16 23949154 2835985 Finally , DHT increased [LPCAT1] expression and PAF release in PC-3 cells in a *dependent* manner . Regulation LPCAT1 WNT2 23949154 2835981 Finally , DHT increased [LPCAT1] expression and PAF release in PC-3 cells in a *dependent* manner . Regulation LPCAT1 WNT3 23949154 2835982 Finally , DHT increased [LPCAT1] expression and PAF release in PC-3 cells in a *dependent* manner . Regulation LPCAT1 WNT4 23949154 2835983 Finally , DHT increased [LPCAT1] expression and PAF release in PC-3 cells in a *dependent* manner . Regulation LPCAT1 WNT6 23949154 2835984 Finally , DHT increased [LPCAT1] expression and PAF release in PC-3 cells in a *dependent* manner . Regulation LPIN1 IL1B 18940942 1994816 Importantly , the LPS induced decrease in lipin-1 mRNA levels was significantly but not totally blunted in TNF-alpha/IL-1 receptor-null mice compared with controls , suggesting key *roles* for and other cytokines in mediating LPS induced repression of [lipin-1] . Regulation LPIN1 TNF 18940942 1994815 Importantly , the LPS induced decrease in lipin-1 mRNA levels was significantly but not totally blunted in TNF-alpha/IL-1 receptor-null mice compared with controls , suggesting key *roles* for and other cytokines in mediating LPS induced repression of [lipin-1] . Regulation LPIN1 TNF 19281795 2055697 Since TNF-alpha is deeply involved in the pathogenesis of obesity , insulin resistance , and diabetes , here we investigated the *role* of on [lipin-1] expression in adipocytes . Regulation LPIN1 TNF 19281795 2055700 These results suggest that could be *involved* in obesity induced [lipin-1] suppression in adipocytes and Jak2 may play an important role in the mechanism . Regulation LPL FAS 11246888 793316 In the present study , we evaluated the direct *effect* of on murine Mo [LPL] expression and examined the involvement of peroxisome proliferator activated receptors ( PPARs ) in this effect . Regulation LPL FAS 11246888 793318 Overall , these results provide the first evidence for a direct regulatory effect of FAs on Mo LPL and suggest a potential role of PPARs in the *regulation* of Mo [LPL] gene expression by . Regulation LPL FAS 19937854 2232202 The objective was to examine the *effects* of n-3 on [LPL] activity considering the occurrence of PPARalpha L162V polymorphism . Regulation LPL SORL1 21385844 2404450 *regulates* the activity of [lipoprotein lipase] by intracellular trafficking . Regulation LPL SORL1 21385844 2404453 By analogy , *regulated* the vesicle-like localization of [LPL] in primary neuronal cells . Regulation LPL TNF 10419646 632065 We show here that the reduction of LPL activity in J774.2 macrophages observed in the presence of interleukin ( IL-1 ) and IL-11 was sensitive to herbimycin A , with the *effect* of LPS , interferon-gamma (IFN-gamma) and on [LPL] activity being sensitive to both herbimycin A and wortmannin . Regulation LPL TNF 16457827 1548011 On the other hand , did not greatly *affect* [LPL] activity using this in vitro model . Regulation LPL TNF 17189708 1695428 The precise mechanism for the inhibition of LPL gene expression by TNFalpha remains to be established in fish , but analysis of the 5'-flanking region evidenced the conservation through vertebrate evolution of a functional OCT-1/NF-Y site that would mediate the *effects* on [LPL] expression . Regulation LPL TNF 2198021 138192 The *effect* of recombinant human on [LPL] activity and mRNA levels in rat epididymal adipose tissue incubated in vitro was examined . Regulation LPL TNF 2575958 124680 3. Inhibition of lipoprotein lipase synthesis in similar experiments in mammals has been attributed to the effects of TNF-alpha and/or IL-1 , but recombinant human and IL-1 had no *effect* on [lipoprotein lipase] activity in chicken adipocytes . Regulation LPL TNF 2695592 125067 The *effects* of the cytokine necrosis factor (TNF) on human adipose tissue [lipoprotein lipase (LPL)] were studied . Regulation LPL TNF 3038858 76209 We also found that the cytotoxic activity of on A673 cells and its inhibitory *effect* on [lipoprotein lipase] were parallel with the cytotoxic activity on L929 cells , but the growth enhancing activity on FS-4 cells and the cytotoxic activity on endothelial cells were not . Regulation LPL TNF 3261386 96050 The *effect* of recombinant human cachectin on [LPL] mRNA levels was shown by nuclear run-on experiments to be exerted transcriptionally . Regulation LPL TNF 3499389 79444 Human recombinant ( 1000 U/ml ) and murine recombinant IL-1 ( 100 U/ml ) did not *affect* [LPL] secretion or cell proliferation in the J774.1 cell line over a period of 72 and 24 h , respectively . Regulation LPL TNF 3597377 75570 Multiple *effects* of on [lipoprotein lipase] in vivo . Regulation LPL TNF 3814100 67676 *Regulation* of [lipoprotein lipase] synthesis in 3T3-L1 adipocytes by . Regulation LPL TNF 7706477 297779 *Regulation* of [LPL] by occurs at the level of LPL gene transcription and posttranscriptionally . Regulation LPL TNF 7947614 277187 Inhibition of activity blocked the increase in serum triglycerides that is characteristically observed after LPS but did not *affect* the ability of LPS to decrease adipose tissue [LPL] activity . Regulation LPL TNF 8670156 369616 The *effect* of recombinant human on synthesis , activity and secretion of [lipoprotein lipase (LPL)] was examined using a human osteosarcoma cell line , osteosarcoma Takase (OST) . Regulation LPL TNF 8732780 374131 Oxidant stress also modulated the *regulation* of macrophage [LPL] production by . Regulation LPL TNF 9369379 464025 The present study examined whether the suppressive *effect* of on [lipoprotein lipase] activity is mediated by production of NO in the brown adipocytes . Regulation LPL TNF 9369379 464027 The suppressive *effect* of on [lipoprotein lipase] activity was significantly prevented by NO synthase inhibitors , NG-nitro-L-arginine methyl ester ( L-NAME ) and aminoguanidine , but not by D-NAME , an inactive isomer . Regulation LPL TNF 9369379 464028 These results suggest that TNF-alpha stimulates brown adipocytes to express inducible NO synthase , followed by production of NO , which in turn mediates the suppressive *effect* of on [lipoprotein lipase] activity . Regulation LPO TNF 16044092 1438021 Thus , Pb increased LPS induced liver damage through PKC and p42/44 MAPK modulation of TNF-alpha and oxidative stress , but modulation of did not *affect* NO or [LPO] in rats . Regulation LRP1 CTGF 24504736 2914186 In addition , [LRP1] *regulates* matrix deposition , in part , by modulating levels of . Regulation LRP1 EPHB2 12499359 1026541 Thus , [LRP-1] *regulates* two signaling proteins in the same cell ( Rac1 and ) , both of which may impact on cell migration . Regulation LRP1 EPHB2 20644732 2292492 Moreover , we found that [LRP-1] is tethered to the actin network and to focal adhesion sites and *controls* and JNK targeting to talin-rich structures . Regulation LRP1 PCSK9 23675525 2785380 Conversely , also *acts* on [LRP-1] in the absence of the LDLR in CHO-A7 cells , where re-introduction of the LDLR leads to reduced PCSK9 mediated degradation of LRP-1 . Regulation LRP1 TNF 17065459 1637493 Endogenously produced was mostly *responsible* for the increase in [LRP-1] expression ; Regulation LRP1 TNF 22298529 2546363 These studies indicate that and IL-1ß *regulate* [LRP-1] in PMCs and that LRP-1 thereby contributes to a range of pathophysiologically relevant responses of these cells . Regulation LRP1 TNF 9182980 436365 In this study , we examined the *effects* of on MRP and [LRP] gene expression in the same colon carcinoma cells . Regulation LRP1 TNFSF10 23178631 2704334 The *effect* of on the expression of multidrug resistant genes MDR1 , [LRP] and GST-p in drug-resistant gastric cancer cell SGC7901/VCR . Regulation LRP10 TNF 9182980 436361 In this study , we examined the *effects* of on MRP and [LRP] gene expression in the same colon carcinoma cells . Regulation LRP10 TNFSF10 23178631 2704330 The *effect* of on the expression of multidrug resistant genes MDR1 , [LRP] and GST-p in drug-resistant gastric cancer cell SGC7901/VCR . Regulation LRP11 TNF 9182980 436362 In this study , we examined the *effects* of on MRP and [LRP] gene expression in the same colon carcinoma cells . Regulation LRP11 TNFSF10 23178631 2704331 The *effect* of on the expression of multidrug resistant genes MDR1 , [LRP] and GST-p in drug-resistant gastric cancer cell SGC7901/VCR . Regulation LRP12 TNF 9182980 436363 In this study , we examined the *effects* of on MRP and [LRP] gene expression in the same colon carcinoma cells . Regulation LRP12 TNFSF10 23178631 2704333 The *effect* of on the expression of multidrug resistant genes MDR1 , [LRP] and GST-p in drug-resistant gastric cancer cell SGC7901/VCR . Regulation LRP2 EPHB2 18927221 2028692 Collectively the AT(1A)R mediated signaling is *involved* in suppressing [megalin] expression in the OK cell line , and insulin competes with this pathway . Regulation LRP2 TNF 9182980 436366 In this study , we examined the *effects* of on MRP and [LRP] gene expression in the same colon carcinoma cells . Regulation LRP2 TNFSF10 23178631 2704335 The *effect* of on the expression of multidrug resistant genes MDR1 , [LRP] and GST-p in drug-resistant gastric cancer cell SGC7901/VCR . Regulation LRP3 TNF 9182980 436367 In this study , we examined the *effects* of on MRP and [LRP] gene expression in the same colon carcinoma cells . Regulation LRP3 TNFSF10 23178631 2704336 The *effect* of on the expression of multidrug resistant genes MDR1 , [LRP] and GST-p in drug-resistant gastric cancer cell SGC7901/VCR . Regulation LRP4 TNF 9182980 436368 In this study , we examined the *effects* of on MRP and [LRP] gene expression in the same colon carcinoma cells . Regulation LRP4 TNFSF10 23178631 2704337 The *effect* of on the expression of multidrug resistant genes MDR1 , [LRP] and GST-p in drug-resistant gastric cancer cell SGC7901/VCR . Regulation LRP5 TNF 9182980 436369 In this study , we examined the *effects* of on MRP and [LRP] gene expression in the same colon carcinoma cells . Regulation LRP5 TNFSF10 23178631 2704338 The *effect* of on the expression of multidrug resistant genes MDR1 , [LRP] and GST-p in drug-resistant gastric cancer cell SGC7901/VCR . Regulation LRP6 TNF 9182980 436370 In this study , we examined the *effects* of on MRP and [LRP] gene expression in the same colon carcinoma cells . Regulation LRP6 TNFSF10 23178631 2704339 The *effect* of on the expression of multidrug resistant genes MDR1 , [LRP] and GST-p in drug-resistant gastric cancer cell SGC7901/VCR . Regulation LRP8 TNF 9182980 436371 In this study , we examined the *effects* of on MRP and [LRP] gene expression in the same colon carcinoma cells . Regulation LRP8 TNFSF10 23178631 2704340 The *effect* of on the expression of multidrug resistant genes MDR1 , [LRP] and GST-p in drug-resistant gastric cancer cell SGC7901/VCR . Regulation LRPAP1 IL1B 22572995 2638069 Collectively , the results indicated that *regulates* expression of IL1R1 and [IL1RAP] and stimulates expression of PTGS1 and PTGS2 that are considered to be the most rate limiting enzymes for endometrial synthesis of PGs during the peri-implantation period of pregnancy in pigs . Regulation LRPAP1 TNF 18438857 1915463 The *effect* of on endogenous binding of c/EBPbeta or SOX9 to the [cd-rap] promoter was examined by chromatin immunoprecipitation assays . Regulation LRPPRC EDN2 19330911 2052612 Here , we investigate whether serum soluble gp130 concentrations correlate with blood pressure in humans , whether gp130 expression in the aorta differs between hypertensive and control rats , and whether angiotensin II or *regulate* [gp130] expression in human VSMC . Regulation LRPPRC IL1B 9326296 457101 These results demonstrate that expression of the genes encoding IL-6 , IL-6R , and [gp130] can be up-regulated in selective regions of the brain in *response* to the bacterial endotoxin LPS and the proinflammatory cytokine ( only for IL-6R expression ) . Regulation LRRC31 XCR1 19797400 2153848 In pursuit of [leucine-rich repeat containing] *regulation* and function in the uterus . Regulation LRRC55 XCR1 19797400 2153867 In pursuit of [leucine-rich repeat containing] *regulation* and function in the uterus . Regulation LRRK2 MAP2K6 20067578 2241602 binds and *regulates* expression of Parkinson 's disease related protein [LRRK2] . Regulation LTA ALOX5 3006030 57280 These findings suggest that a single protein from human leukocytes possesses <5-lipoxygenase> and LTA4 synthase activities and that the synthesis of [LTA4] from 5-HPETE is *controlled* by the same complex multicomponent system that regulates the 5-lipoxygenase reaction . Regulation LTB ALOX5 1320811 190149 We used a specific 5-lipoxygenase inhibitor , A-63162 , to examine the *role* of <5-lipoxygenase (5-LO)> in equine blood mononuclear cell ( BMC ) proliferation and [leukotriene B4 (LTB4)] synthesis after stimulation with mitogen ( phytohemagglutinin , PHA ) or calcium ionophore ( A23187 ) . Regulation LTB ALOX5 20436887 2181467 Synthesis of [LTB] ( 4 ) is *controlled* by the enzyme <5-lipoxygenase> . Regulation LTB ALOX5 7488299 323024 This study has examined the *effects* of a new <5-lipoxygenase> inhibitor , 6-hydroxy-2- ( 4-sulfamoylbenzylamino ) -4,5,7-trimethylbenzothiazo le hydrochloride ( CAS 120164-49-0 , E6080 ) on the release of LTC4 , [LTB4] and PAF by human eosinophils , Eosinophils stimulated by 1 mumol/l calcium ionophore A23187 for 15 min released 37.5 +/- 2.2 ng , 2.3 +/- 0.3 ng and 4.0 +/- 0.3 pmol per 10 ( 6 ) cells of immunoreactive LTC4 , LTB4 and PAF , respectively ( mean +/- SEM , n = 4 ) . Regulation LTB ALOX5 8299991 248605 As with other antioxidant compounds , several of the chalcogenides were relatively selective inhibitors of monocyte <5'-lipoxygenase> *dependent* secretion of [LTB4] as compared to their effect on cyclooxygenase dependent secretion of PGE2 ( for example compound 42 had IC50s of 0.6 microM and 10 microM , respectively ) . Regulation LTB ALOX5 8596775 342601 Because leukotriene ( LT ) production is considered to play an important role in the pathophysiology of UC , we examined the *effect* of the anti-allergic drugs , azelastine and tranilast , and the <5-lipoxygenase> inhibitor , AA861 , on [LTB4] and LTC4 production by isolated rat colonic mucosa treated with the calcium ionophore , A23187 . Regulation LTB ALOX5 8845830 337979 The role of leukotriene B4 (LTB4) in leukocyte infiltration in zymosan induced rat pleurisy was investigated by studying the *effects* of <5-lipoxygenase> inhibitors , T-0757 and AA-861 , and a cyclooxygenase inhibitor , indomethacin , on leukocyte infiltration and [LTB4] levels in the inflammatory exudate of rat pleurisy induced by intrapleural injection of zymosan ( 20 mg/rat ) . Regulation LTB IL1B 15910501 1411998 Hepatic expression of the tumor necrosis factor family member [lymphotoxin-beta] is *regulated* by interleukin (IL)-6 and : transcriptional control mechanisms in oval cells and hepatoma cell lines . Regulation LTB IL1B 1649133 160897 The *effects* of recombinant human on the production of prostaglandin E2 ( PGE2 ) , [leukotriene B4 (LTB4)] , N-acetyl-beta-D-glucosaminidase ( NAG ) , and superoxide by synovial cells and chondrocytes derived from osteoarthritis patients were determined . Regulation LTB IL1B 8384162 214730 The CF mediator levels showed increased levels of PGE2 and TxB2 at the ligated sites , as compared with the spontaneous sites , with no significant contralateral differences in the or [LTB4] *responses* . Regulation LTB IL1B 9777883 540271 In conclusion , beta2-agonists exhibited only minor effects on secretion from blood monocytes and no *effect* on [LTB4-secretion] from either cell type , and budesonide effectively inhibited the IL-1beta release in blood monocytes , but not in alveolar macrophages . Regulation LTB TLR7 22119018 2548447 Additionally , the production of LTB ( 4 ) and PGE ( 2 ) were inhibited following treatment of heterophils with the specific pharmacologic inhibitor of NF-?B ( Bay 11-7086 ) , thus suggesting that pathway activation of NF-?B *controls* [LTB] ( 4 ) and PGE ( 2 ) production . Regulation LTB TNF 15034048 1223612 In this study we report the characterization of mechanisms governing both basal as well as PMA- and *regulation* of the human [LT-beta] promoter . Regulation LTB TNF 1846897 153390 We have further examined the *effects* of on arachidonic acid ( AA ) release , [LTB4] production , and platelet activating factor (PAF) formation in PMN by prelabeling cells with either [ 3H ] AA or [ 3H ] lyso-PAF , priming with human rTNF-alpha , and then stimulating with the chemotactic peptide , FMLP . Regulation LTB TNF 24736410 2949965 Conversely , cathelicidin-deficient ( Cnlp ( -/- ) ) mice produce much less [LTB4] and TXB2 in vivo in *response* to compared with control mice . Regulation LTB TNF 2552773 119156 *Effect* of on granule release and [LTB4] production in adherent human polymorphonuclear leukocytes . Regulation LTB TNF 7644564 318765 However , IL-3 or IL-5 lacked this effect when stimulated with exogenous arachidonic acid A at 10 ( -4 ) M . and TGF-alpha had no priming *effect* on [LTB4] synthesis following stimulation with either A23187 ( 5x10 ( -9 ) M ) or AA ( 10 ( -4 ) M ) . Regulation LTC4S TNF 16980379 1673711 The *effect* of on [LTC(4) synthase] mRNA expression was mediated via the MEK/ERK pathway , but not via cyclooxygenase or nitric oxide synthase pathways . Regulation LTF RAB31 15936113 1445865 Since Rab3 , a neuronal GTP binding protein , is known to be a key regulator of synaptic vesicle fusion , we investigated the *involvement* of in [LTF] . Regulation LTF TNF 2069802 162591 *Effect* of Escherichia coli , Streptococcus agalactiae and on [lactoferrin] release and the generation of tissue thromboplastin . Regulation LTF TNF 2248767 145986 Using an in vitro model , we report the early *effect* of Escherichia coli ( E. coli ) , Streptococcus agalactiea ( group B streptococci , GBS ) and recombinant on the release of [lactoferrin (LF)] and the generation of interleukin-1 (IL-1) due to E. coli , using heparinized whole blood from healthy full-term newborns . Regulation LTF TNF 8695817 372864 To determine if *plays* a role in H2O2 and [lactoferrin] release , we investigated the effect of anti-TNF alpha antibodies on FMLP stimulated activation of adherent PMN . Regulation LTF TNF 9916742 587530 Human PMN incubated on fibrinogen released [lactoferrin] in *response* to and this response was inhibited by PP1 , a Src family tyrosine kinase inhibitor . Regulation LTF TNF 9916742 587532 Double knockout hck-/- fgr-/- PMN adherent to collagen or fibrinogen failed to release [lactoferrin] in *response* to but responded to PMA as wild-type PMN . Regulation LUM FAS 15623759 1358493 [Lumican] *regulates* corneal inflammatory responses by modulating ligand signaling . Regulation LY6E TNF 1717166 166672 Multiple cytokine interactions *regulate* [Ly-6E] antigen expression : cooperative Ly-6E induction by IFNs , , and IL-1 in a T cell lymphoma and in its induction-deficient variants . Regulation LY96 CD14 20092898 2212754 Meconium induced release of cytokines is mediated by the [TRL4/MD-2] complex in a *dependent* manner . Regulation LYN TNF 22302035 2624200 Analyzing two local MC-dependent innate immune responses in vivo , we found that [Lyn] positively *controls* early production and immune cell recruitment after an intraperitoneal injection of LPS . Regulation LYNX1 FGFR3 17286989 1747336 These results suggest that both SLURP-1 and [SLURP-2] are expressed in various immune cells and organs , and that not only but also SLURPs may be *involved* in regulating lymphocyte function via nAChR mediated pathways . Regulation MAD1L1 STK39 18083840 1837872 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation MADCAM1 ARSA 11472325 841440 <5-ASA> , sulfasalazine and 6-MP , while beneficial in inflammatory bowel disease , do not directly *control* [MAdCAM-1] , and are beneficial through inhibition of other inflammatory processes . Regulation MADCAM1 TNF 11546645 856532 We used two endothelial lines [ bEND.3 ( brain ) and SVEC ( high endothelium ) ] to study the signal paths that regulate [MAdCAM-1] expression in *response* to using RT-PCR , blotting , adhesion , and immunofluorescence . Regulation MADCAM1 TNF 16190815 1462614 SV-LEC also expresses [MAdCAM-1] in *response* to , an effect seen in VEC , but not AEC . Regulation MADCAM1 TNF 21981016 2547168 We investigated how expression of ICAM-1 , VCAM-1 , [MAdCAM-1] , PECAM-1 , E- and P-selectin in *response* to , IL-1ß and IFN-? was altered by aglycemia ( A ) , hypoxia ( H ) or combined oxygen glucose deprivation ( OGD ) . Regulation MADCAM1 TNF 23328772 2738414 As tumor necrosis factor alpha (TNF)-a , a cytokine centrally involved in CD , modulates gut endothelial adhesion molecules , we here explored the in vivo and ex vivo *effects* of blockade on [MAdCAM-1] expression in CD . Regulation MAFB EPHB2 15121870 1242203 [MafB/Kreisler] is induced in *response* to and synergizes with GATA and Ets to enhance transcription from the proximal promoter . Regulation MAG PLAT 24129569 2875076 LRP1 assembles unique co-receptor systems to initiate cell signaling in *response* to and [myelin associated glycoprotein] . Regulation MAMLD1 NR5A1 18987498 1983762 and ( 5 ) [CXorf6] can be *regulated* by . Regulation MAMLD1 PET100 20353275 2231459 Comparing patients with and without [F-18] FDG *response* , there was statistically significant difference in overall survival between the 2 groups ( median survival time , responder , 29.4 month ; non-responder , 14.2 month , Chi ( 2 ) =3.91 , p=0.048 ) . Regulation MAMLD1 PET112 20353275 2231461 Comparing patients with and without [F-18] FDG *response* , there was statistically significant difference in overall survival between the 2 groups ( median survival time , responder , 29.4 month ; non-responder , 14.2 month , Chi ( 2 ) =3.91 , p=0.048 ) . Regulation MAMLD1 PET117 20353275 2231460 Comparing patients with and without [F-18] FDG *response* , there was statistically significant difference in overall survival between the 2 groups ( median survival time , responder , 29.4 month ; non-responder , 14.2 month , Chi ( 2 ) =3.91 , p=0.048 ) . Regulation MAMLD1 SF1 23044878 2684714 and ( 4 ) [MAMLD1] is *regulated* by . Regulation MAMLD1 THBS1 11358957 834498 Exogenous fibronectin also stimulated *dependent* binding of [F18] to melanoma cells . Regulation MANF TNF 17158207 1694192 Western blot analysis of L6 cell lysates demonstrated impaired insulin stimulated phosphorylation of Akt , [serine/arginine-rich protein] 40 , and glycogen synthase kinase 3beta in *response* to and the short chain C6 ceramide analog . Regulation MAOA BCL10 23926250 2826570 Rines E3 *regulates* [MAO-A] levels and emotional responses . Regulation MAOA CA2 14735783 1181947 This is the first evidence that ammonia and *regulate* [MAO A] in non-synaptic mitochondria in the forebrain and can contribute to oxidative stress in the neurons via MAO A activation . Regulation MAOA IL4 15470022 1317858 In promyelomonocytic U937 cells , which neither express 15-LOX1 nor [MAO-A] in *response* to stimulation , expression of MAO-A was up-regulated following transfection with 15-LOX1 . Regulation MAOA MALT1 23926250 2826569 Rines E3 *regulates* [MAO-A] levels and emotional responses . Regulation MAOA MAOB 7803985 284663 Since [MAO-A] is an isoform of MAO that preferentially uses norepinephrine and serotonin as substrates and *acts* on phenylethylamine and benzylamine as substrates , our findings suggest that the restoration of sexual behavior after the treatment with estradiol benzoate followed by progesterone may be associated with the differential effect exerted by the hormones on MAO subtypes , rather than to the simple decrease in hypothalamic monoamine concentrations as reported in the literature . Regulation MAOA MPZ 3494215 72314 We studied the *effect* of on type A [monoamine oxidase (MAO-A)] activity in mitochondria prepared from various sources . Regulation MAOA TAB2 23926250 2826568 Rines E3 *regulates* [MAO-A] levels and emotional responses . Regulation MAOA TRAF6 23926250 2826566 Rines E3 *regulates* [MAO-A] levels and emotional responses . Regulation MAOA UBE2V1 23926250 2826567 Rines E3 *regulates* [MAO-A] levels and emotional responses . Regulation MAOB MAOA 7803985 284664 Since is an isoform of MAO that preferentially uses norepinephrine and serotonin as substrates and [MAO-B] *acts* on phenylethylamine and benzylamine as substrates , our findings suggest that the restoration of sexual behavior after the treatment with estradiol benzoate followed by progesterone may be associated with the differential effect exerted by the hormones on MAO subtypes , rather than to the simple decrease in hypothalamic monoamine concentrations as reported in the literature . Regulation MAP1LC3A EPHB2 25128814 2957268 can *regulate* cellular levels of [LC3B] and SQSTM1/p62 at expression levels . Regulation MAP1LC3A MAP2K6 25128814 2957274 can *regulate* cellular levels of [LC3B] and SQSTM1/p62 at expression levels . Regulation MAP2 CAPN8 16904106 1639003 Microtubule disruption , not *dependent* loss of [MAP2] , contributes to enduring NMDA induced dendritic dysfunction in acute hippocampal slices . Regulation MAP2 S100B 9237496 445645 The *effects* of on neurite length and [microtubule associated protein2 (MAP2)] immunoreactivity ( IR ) after microtubule disruption with colchicine were investigated in primary rat spinal cord culture . Regulation MAP2K1 CCND1 24342356 2917002 Further studies showed that SUMOylation at Lys-138 was critical for RhoGDIa down-regulation of protein expression and that [MEK1/2-Erk] was a specific downstream *target* of SUMOylated RhoGDIa for its inhibition of C-Jun/AP-1 cascade , cyclin d1 transcription , and cell cycle progression . Regulation MAP2K1 CD14 16879219 1593877 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by [MEK/ERK] signaling and NFkappaB activation and that membrane bound and TLR-4 are *involved* in this mechanism . Regulation MAP2K1 EPHB2 21077177 2371552 The reduction of EC-SOD and Cu/Zn-SOD was attenuated by pretreatments with GF109203X ( an inhibitor of protein kinase C , PKC ) , diphenyleneiodonium ( an inhibitor of NOX ) , and U0126 ( an inhibitor of mitogen activated protein kinase kinase , [MEK/extracellular-signal] *regulated* kinase , ) . Regulation MAP2K1 EPHB2 22740332 2715459 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Regulation MAP2K1 IL1B 10965886 728049 In addition , the MAP kinase-kinase [MEK-1] and the ribosomal S6-kinase RSK-1 are also phosphorylated in *response* to . Regulation MAP2K1 NEDD9 15169888 1253612 Interaction with is required to maintain TPL-2 metabolic stability and also negatively *regulates* TPL-2 [MEK] kinase activity . Regulation MAP2K1 PLAU 15874933 1405711 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( [MEK1/2] ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Regulation MAP2K2 CD14 16879219 1593879 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by [MEK/ERK] signaling and NFkappaB activation and that membrane bound and TLR-4 are *involved* in this mechanism . Regulation MAP2K2 EPHB2 21077177 2371553 The reduction of EC-SOD and Cu/Zn-SOD was attenuated by pretreatments with GF109203X ( an inhibitor of protein kinase C , PKC ) , diphenyleneiodonium ( an inhibitor of NOX ) , and U0126 ( an inhibitor of mitogen activated protein kinase kinase , [MEK/extracellular-signal] *regulated* kinase , ) . Regulation MAP2K2 EPHB2 22740332 2715460 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Regulation MAP2K2 NEDD9 15169888 1253613 Interaction with is required to maintain TPL-2 metabolic stability and also negatively *regulates* TPL-2 [MEK] kinase activity . Regulation MAP2K3 CD14 16879219 1593881 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by [MEK/ERK] signaling and NFkappaB activation and that membrane bound and TLR-4 are *involved* in this mechanism . Regulation MAP2K3 EPHB2 21077177 2371554 The reduction of EC-SOD and Cu/Zn-SOD was attenuated by pretreatments with GF109203X ( an inhibitor of protein kinase C , PKC ) , diphenyleneiodonium ( an inhibitor of NOX ) , and U0126 ( an inhibitor of mitogen activated protein kinase kinase , [MEK/extracellular-signal] *regulated* kinase , ) . Regulation MAP2K3 EPHB2 22740332 2715461 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Regulation MAP2K3 NEDD9 15169888 1253614 Interaction with is required to maintain TPL-2 metabolic stability and also negatively *regulates* TPL-2 [MEK] kinase activity . Regulation MAP2K3 PLAU 15874933 1405712 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , [MAP kinase kinase (MKK)3/6] , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Regulation MAP2K4 CD14 16879219 1593883 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by [MEK/ERK] signaling and NFkappaB activation and that membrane bound and TLR-4 are *involved* in this mechanism . Regulation MAP2K4 EPHB2 21077177 2371555 The reduction of EC-SOD and Cu/Zn-SOD was attenuated by pretreatments with GF109203X ( an inhibitor of protein kinase C , PKC ) , diphenyleneiodonium ( an inhibitor of NOX ) , and U0126 ( an inhibitor of mitogen activated protein kinase kinase , [MEK/extracellular-signal] *regulated* kinase , ) . Regulation MAP2K4 EPHB2 22740332 2715462 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Regulation MAP2K4 NEDD9 15169888 1253615 Interaction with is required to maintain TPL-2 metabolic stability and also negatively *regulates* TPL-2 [MEK] kinase activity . Regulation MAP2K4 TNF 19026990 2022765 [MKK4] is a novel *target* for the inhibition of induced vascular endothelial growth factor expression by myricetin . Regulation MAP2K5 CD14 16879219 1593885 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by [MEK/ERK] signaling and NFkappaB activation and that membrane bound and TLR-4 are *involved* in this mechanism . Regulation MAP2K5 EPHB2 21077177 2371556 The reduction of EC-SOD and Cu/Zn-SOD was attenuated by pretreatments with GF109203X ( an inhibitor of protein kinase C , PKC ) , diphenyleneiodonium ( an inhibitor of NOX ) , and U0126 ( an inhibitor of mitogen activated protein kinase kinase , [MEK/extracellular-signal] *regulated* kinase , ) . Regulation MAP2K5 EPHB2 22740332 2715463 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Regulation MAP2K5 NEDD9 15169888 1253616 Interaction with is required to maintain TPL-2 metabolic stability and also negatively *regulates* TPL-2 [MEK] kinase activity . Regulation MAP2K6 AHSA1 9607326 508492 Pervanadate inhibits [mitogen activated protein kinase kinase-1] in a *dependent* manner . Regulation MAP2K6 AKT1 12527803 1048404 *dependent* phosphorylation of serine 1179 and [mitogen activated protein kinase kinase/extracellular] signal regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide . Regulation MAP2K6 AKT2 12527803 1048405 *dependent* phosphorylation of serine 1179 and [mitogen activated protein kinase kinase/extracellular] signal regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide . Regulation MAP2K6 AKT3 12527803 1048406 *dependent* phosphorylation of serine 1179 and [mitogen activated protein kinase kinase/extracellular] signal regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide . Regulation MAP2K6 BRAF 18715233 1968270 These data suggest that *regulation* of BIM expression by -- > [MEK] -- > ERK signaling is one mechanism by which oncogenic BRAF ( V600E ) can influence the aberrant physiology of melanoma cells . Regulation MAP2K6 BRAF 19406750 2095673 , an upstream *regulator* of [MEK] , constitutively interacts with residues 1-445 and 446-1250 . Regulation MAP2K6 BRAF 19835659 2154965 In addition , in order to investigate whether [MEK] is *regulated* by , we examined the B-Raf and MEK interaction . Regulation MAP2K6 CA2 18034335 1924461 In summary , the activation of TRPV1 by capsaicin modulates the SP release from DRG neurons via two different mechanisms , one requiring extracellular , the activation of PI3K and the IP3 dependent intracellular Ca2+ release , and the other which is independent of extracellular Ca2+ but *involves* the activation of [MEK] . Regulation MAP2K6 CASP1 11331275 827400 Here , we demonstrate that the growth-promoting/pro-survival signaling molecule [mitogen activated protein kinase kinase] ( MEK ) is cleaved in a *dependent* manner in murine squamous cell carcinoma (SCC) cells induced to undergo apoptosis by treatment with vitamin D ( 3 ) . Regulation MAP2K6 CASP1 12231068 988559 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Regulation MAP2K6 CASP1 16886662 1596613 Calcitriol induces G0/G1 arrest , modulates p27 and p21 , the cyclin dependent kinase (cdk) inhibitors implicated in G1 arrest , and induces cleavage of caspase 3 , PARP and the [mitogen activated protein kinase (MEK)] in a *dependent* manner . Regulation MAP2K6 CASP10 11331275 827401 Here , we demonstrate that the growth-promoting/pro-survival signaling molecule [mitogen activated protein kinase kinase] ( MEK ) is cleaved in a *dependent* manner in murine squamous cell carcinoma (SCC) cells induced to undergo apoptosis by treatment with vitamin D ( 3 ) . Regulation MAP2K6 CASP10 12231068 988560 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Regulation MAP2K6 CASP10 16886662 1596614 Calcitriol induces G0/G1 arrest , modulates p27 and p21 , the cyclin dependent kinase (cdk) inhibitors implicated in G1 arrest , and induces cleavage of caspase 3 , PARP and the [mitogen activated protein kinase (MEK)] in a *dependent* manner . Regulation MAP2K6 CASP12 11331275 827411 Here , we demonstrate that the growth-promoting/pro-survival signaling molecule [mitogen activated protein kinase kinase] ( MEK ) is cleaved in a *dependent* manner in murine squamous cell carcinoma (SCC) cells induced to undergo apoptosis by treatment with vitamin D ( 3 ) . Regulation MAP2K6 CASP12 12231068 988570 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Regulation MAP2K6 CASP12 16886662 1596624 Calcitriol induces G0/G1 arrest , modulates p27 and p21 , the cyclin dependent kinase (cdk) inhibitors implicated in G1 arrest , and induces cleavage of caspase 3 , PARP and the [mitogen activated protein kinase (MEK)] in a *dependent* manner . Regulation MAP2K6 CASP14 11331275 827402 Here , we demonstrate that the growth-promoting/pro-survival signaling molecule [mitogen activated protein kinase kinase] ( MEK ) is cleaved in a *dependent* manner in murine squamous cell carcinoma (SCC) cells induced to undergo apoptosis by treatment with vitamin D ( 3 ) . Regulation MAP2K6 CASP14 12231068 988561 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Regulation MAP2K6 CASP14 16886662 1596615 Calcitriol induces G0/G1 arrest , modulates p27 and p21 , the cyclin dependent kinase (cdk) inhibitors implicated in G1 arrest , and induces cleavage of caspase 3 , PARP and the [mitogen activated protein kinase (MEK)] in a *dependent* manner . Regulation MAP2K6 CASP16 11331275 827412 Here , we demonstrate that the growth-promoting/pro-survival signaling molecule [mitogen activated protein kinase kinase] ( MEK ) is cleaved in a *dependent* manner in murine squamous cell carcinoma (SCC) cells induced to undergo apoptosis by treatment with vitamin D ( 3 ) . Regulation MAP2K6 CASP16 12231068 988571 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Regulation MAP2K6 CASP16 16886662 1596625 Calcitriol induces G0/G1 arrest , modulates p27 and p21 , the cyclin dependent kinase (cdk) inhibitors implicated in G1 arrest , and induces cleavage of caspase 3 , PARP and the [mitogen activated protein kinase (MEK)] in a *dependent* manner . Regulation MAP2K6 CASP2 11331275 827403 Here , we demonstrate that the growth-promoting/pro-survival signaling molecule [mitogen activated protein kinase kinase] ( MEK ) is cleaved in a *dependent* manner in murine squamous cell carcinoma (SCC) cells induced to undergo apoptosis by treatment with vitamin D ( 3 ) . Regulation MAP2K6 CASP2 12231068 988562 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Regulation MAP2K6 CASP2 16886662 1596616 Calcitriol induces G0/G1 arrest , modulates p27 and p21 , the cyclin dependent kinase (cdk) inhibitors implicated in G1 arrest , and induces cleavage of caspase 3 , PARP and the [mitogen activated protein kinase (MEK)] in a *dependent* manner . Regulation MAP2K6 CASP3 11331275 827404 Here , we demonstrate that the growth-promoting/pro-survival signaling molecule [mitogen activated protein kinase kinase] ( MEK ) is cleaved in a *dependent* manner in murine squamous cell carcinoma (SCC) cells induced to undergo apoptosis by treatment with vitamin D ( 3 ) . Regulation MAP2K6 CASP3 12231068 988563 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Regulation MAP2K6 CASP3 16886662 1596617 Calcitriol induces G0/G1 arrest , modulates p27 and p21 , the cyclin dependent kinase (cdk) inhibitors implicated in G1 arrest , and induces cleavage of caspase 3 , PARP and the [mitogen activated protein kinase (MEK)] in a *dependent* manner . Regulation MAP2K6 CASP4 11331275 827405 Here , we demonstrate that the growth-promoting/pro-survival signaling molecule [mitogen activated protein kinase kinase] ( MEK ) is cleaved in a *dependent* manner in murine squamous cell carcinoma (SCC) cells induced to undergo apoptosis by treatment with vitamin D ( 3 ) . Regulation MAP2K6 CASP4 12231068 988564 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Regulation MAP2K6 CASP4 16886662 1596618 Calcitriol induces G0/G1 arrest , modulates p27 and p21 , the cyclin dependent kinase (cdk) inhibitors implicated in G1 arrest , and induces cleavage of caspase 3 , PARP and the [mitogen activated protein kinase (MEK)] in a *dependent* manner . Regulation MAP2K6 CASP5 11331275 827406 Here , we demonstrate that the growth-promoting/pro-survival signaling molecule [mitogen activated protein kinase kinase] ( MEK ) is cleaved in a *dependent* manner in murine squamous cell carcinoma (SCC) cells induced to undergo apoptosis by treatment with vitamin D ( 3 ) . Regulation MAP2K6 CASP5 12231068 988565 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Regulation MAP2K6 CASP5 16886662 1596619 Calcitriol induces G0/G1 arrest , modulates p27 and p21 , the cyclin dependent kinase (cdk) inhibitors implicated in G1 arrest , and induces cleavage of caspase 3 , PARP and the [mitogen activated protein kinase (MEK)] in a *dependent* manner . Regulation MAP2K6 CASP6 11331275 827407 Here , we demonstrate that the growth-promoting/pro-survival signaling molecule [mitogen activated protein kinase kinase] ( MEK ) is cleaved in a *dependent* manner in murine squamous cell carcinoma (SCC) cells induced to undergo apoptosis by treatment with vitamin D ( 3 ) . Regulation MAP2K6 CASP6 12231068 988566 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Regulation MAP2K6 CASP6 16886662 1596620 Calcitriol induces G0/G1 arrest , modulates p27 and p21 , the cyclin dependent kinase (cdk) inhibitors implicated in G1 arrest , and induces cleavage of caspase 3 , PARP and the [mitogen activated protein kinase (MEK)] in a *dependent* manner . Regulation MAP2K6 CASP7 11331275 827408 Here , we demonstrate that the growth-promoting/pro-survival signaling molecule [mitogen activated protein kinase kinase] ( MEK ) is cleaved in a *dependent* manner in murine squamous cell carcinoma (SCC) cells induced to undergo apoptosis by treatment with vitamin D ( 3 ) . Regulation MAP2K6 CASP7 12231068 988567 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Regulation MAP2K6 CASP7 16886662 1596621 Calcitriol induces G0/G1 arrest , modulates p27 and p21 , the cyclin dependent kinase (cdk) inhibitors implicated in G1 arrest , and induces cleavage of caspase 3 , PARP and the [mitogen activated protein kinase (MEK)] in a *dependent* manner . Regulation MAP2K6 CASP8 11331275 827409 Here , we demonstrate that the growth-promoting/pro-survival signaling molecule [mitogen activated protein kinase kinase] ( MEK ) is cleaved in a *dependent* manner in murine squamous cell carcinoma (SCC) cells induced to undergo apoptosis by treatment with vitamin D ( 3 ) . Regulation MAP2K6 CASP8 12231068 988568 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Regulation MAP2K6 CASP8 16886662 1596622 Calcitriol induces G0/G1 arrest , modulates p27 and p21 , the cyclin dependent kinase (cdk) inhibitors implicated in G1 arrest , and induces cleavage of caspase 3 , PARP and the [mitogen activated protein kinase (MEK)] in a *dependent* manner . Regulation MAP2K6 CASP9 11331275 827410 Here , we demonstrate that the growth-promoting/pro-survival signaling molecule [mitogen activated protein kinase kinase] ( MEK ) is cleaved in a *dependent* manner in murine squamous cell carcinoma (SCC) cells induced to undergo apoptosis by treatment with vitamin D ( 3 ) . Regulation MAP2K6 CASP9 12231068 988569 Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage , increases bax/bcl-2 ratio , reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt , induces *dependent* [mitogen activated protein kinase kinase] ( MEK ) cleavage and upregulation of MEK kinase-1 , all potential markers of the apoptotic pathway . Regulation MAP2K6 CASP9 16886662 1596623 Calcitriol induces G0/G1 arrest , modulates p27 and p21 , the cyclin dependent kinase (cdk) inhibitors implicated in G1 arrest , and induces cleavage of caspase 3 , PARP and the [mitogen activated protein kinase (MEK)] in a *dependent* manner . Regulation MAP2K6 CD14 16879219 1593887 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by [MEK/ERK] signaling and NFkappaB activation and that membrane bound and TLR-4 are *involved* in this mechanism . Regulation MAP2K6 CD44 20956971 2389492 The results raise the novel idea that the EGFR may activate [Raf-MEK-ERK] signaling in *response* to the binding of HA to . Regulation MAP2K6 CDC37 10022854 590253 In this study , we examined the *role* of and its Hsp90 chaperone partner in [Raf/Mek/MAPK] signaling biochemically . Regulation MAP2K6 CDC42 11304531 826861 Galpha ( q ) stimulated MKK3 in a Rac- and *dependent* manner and [MKK6] in a Rho dependent manner . Regulation MAP2K6 CDC42 11304531 826863 On the other hand , Gbetagamma activated MKK3 in a Rac- and *dependent* manner and [MKK6] in a Rho- , Rac- , and Cdc42 dependent manner . Regulation MAP2K6 CDH13 12832462 1105632 NF-kappaB1 negatively *regulates* TPL-2 [MEK] kinase activity . Regulation MAP2K6 CDKN1A 18381422 1892878 c-Jun NH2-terminal kinase activating kinase [1/mitogen activated protein kinase kinase] 4-mediated inhibition of SKOV3ip.1 ovarian cancer metastasis *involves* growth arrest and up-regulation . Regulation MAP2K6 DNM1 10585393 571179 In contrast , does not *affect* the activation of Ras , Raf , and [MAP kinase kinase (MEK)] by either agonist . Regulation MAP2K6 DNM2 10585393 571180 In contrast , does not *affect* the activation of Ras , Raf , and [MAP kinase kinase (MEK)] by either agonist . Regulation MAP2K6 DNM3 10585393 571178 In contrast , does not *affect* the activation of Ras , Raf , and [MAP kinase kinase (MEK)] by either agonist . Regulation MAP2K6 DUSP1 24253595 2910524 Thus , [MEK/ERK] activity *controls* the levels of and , thereby , regulates JNK activity in polyamine depleted cells . Regulation MAP2K6 DUSP10 16181551 1462002 Both SHP2 and *play* some roles in P2Y receptor mediated activation of [MEK/ERK] , p38 signaling pathways and prostate cancer invasion . Regulation MAP2K6 DUSP6 19106095 2031532 Intriguingly , we observed that [Mek] is positively *regulated* by , whereas Erk itself is negatively regulated . Regulation MAP2K6 EDN1 8772428 379423 To evaluate a possible mechanism for the chronic regulation of MEK and p42 MAPK , we studied the long-term *effects* of fetal bovine serum ( FBS ) , the G protein coupled receptor agonist , and the protein tyrosine kinase coupled receptor agonist platelet derived growth factor BB ( PDGF BB ) on [MEK] and p42 MAPK in glomerular mesangial cells ( GMC ) . Regulation MAP2K6 EGF 10648842 662251 Hepatic *regulated* [mitogen activated protein kinase kinase] kinase activity in the rat : lack of identity with known forms of raf and MEKK . Regulation MAP2K6 EGF 8529659 336795 Activation of two isoforms of [mitogen activated protein kinase kinase] in *response* to and nerve growth factor . Regulation MAP2K6 EPHB2 21077177 2371557 The reduction of EC-SOD and Cu/Zn-SOD was attenuated by pretreatments with GF109203X ( an inhibitor of protein kinase C , PKC ) , diphenyleneiodonium ( an inhibitor of NOX ) , and U0126 ( an inhibitor of mitogen activated protein kinase kinase , [MEK/extracellular-signal] *regulated* kinase , ) . Regulation MAP2K6 EPHB2 22740332 2715464 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Regulation MAP2K6 EPO 15026317 1257129 *regulation* of Raf-1 and [MEK] : evidence for a Ras independent mechanism . Regulation MAP2K6 GDNF 11595754 870234 These results suggested that amitriptyline induced synthesis and release occurred at the transcriptional level , and may be *regulated* by [MEK/MAPK] signalling . Regulation MAP2K6 GRAP2 10978313 751973 Moreover , the constitutive p38 activator [MKK6] also suppressed Ras activity in a *dependent* manner whereas arsenite , a potent chemical inducer of p38 , inhibited proliferation only in a tumor cell line that required Ras activity . Regulation MAP2K6 GRM3 21946352 2497681 Biochemical analysis of GRM3 alterations revealed that mutant selectively *regulated* the phosphorylation of [MEK] , leading to increased anchorage independent growth and migration . Regulation MAP2K6 HRAS 22847612 2803139 The Bach1-deficient cells showed diminished phosphorylation of [MEK] and ERK1/2 in *response* to ( V12 ) , which was consistent with the alterations in the gene expression profile , including phosphatase genes . Regulation MAP2K6 HRAS 7611406 312116 In conclusion , the activation of MAP kinase by CCK can be explained by activation of [MEK] and may *involve* the activation of by a protein kinase C-dependent mechanism . Regulation MAP2K6 HRAS 8014190 262465 The Raf dependent pathway involves Ras activation , while the Raf independent activation of [MEK] and MAPK does not *involve* . Regulation MAP2K6 IFI44 15064239 1231261 These results suggest that in HTSMCs , LTA stimulated MAPK phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , [MEK] , and PI 3-kinase . Regulation MAP2K6 IGF1 16487514 1534909 The induced increase in DNA replication was abolished by LY294002 and only partially inhibited by PD98059 , suggesting that phosphoinositol-3' kinase (PI-3'K) and to a lesser extent [MEK/Erk] signaling were *involved* . Regulation MAP2K6 IGF1R 19574224 2122213 we validated that [MEK-ERK] signaling was also induced in an *dependent* manner in some cancer cell lines . Regulation MAP2K6 IL4 16210650 1464503 *regulates* [MEK] expression required for lysophosphatidic acid mediated chemokine generation by human mast cells . Regulation MAP2K6 IL5 12759409 1091103 Eosinophils incubated with IL-5 or IL-3 showed diminished respiratory burst and [mitogen activated protein kinase kinase] phosphorylation in *response* to further stimulation . Regulation MAP2K6 IL6 15345332 1292173 These findings suggest that BK increased both and PGE ( 2 ) synthesis in osteoblastic cells via B2R and that PLC , IP ( 3 ) -induced [ Ca ( 2+ ) ] i , [MEK] , and MAPKs were *involved* in the signal transduction in these cells . Regulation MAP2K6 INS 11466321 851031 Cholesterol depletion also blocked *dependent* phosphorylation of [MEK] and mitogen activated protein kinase (MAPK) but had no effects on the translocation and activation of Raf-1 . Regulation MAP2K6 INS 15169830 1295180 Although the mitogen activated protein kinases ( MAPKs ) extracellular signal regulated kinase , p38 MAPK , and JNK ( c-Jun N-terminal kinase ) were activated in *response* to , PD98059 ( 2'-amino-3'-methoxyflavone ) , an inhibitor of [mitogen activated protein kinase kinase] , SP600125 ( 1,9-pyrazoloanthrone ) , an inhibitor of JNK , and SB203580 [ 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) 1H-imidazole ] , an inhibitor of p38 MAPK , failed to inhibit the insulin mediated increase in GCLC protein levels . Regulation MAP2K6 INS 7677789 326416 The expression of dominant negative Syp blocked the activation of [MEK] and raf-1 kinase in *response* to and had no detectable effect on insulin induced activation of p21ras . Regulation MAP2K6 INS 8641187 362821 Reduced phosphorylation of [mitogen activated protein kinase kinase] in *response* to in cells with truncated C-terminal domain of insulin receptor . Regulation MAP2K6 INS 9169593 429848 *regulation* of [mitogen activated protein kinase kinase] ( MEK ) , mitogen activated protein kinase and casein kinase in the cell nucleus : a possible role in the regulation of gene expression . Regulation MAP2K6 IQGAP1 17563371 1763024 We previously documented that binds ERK and MAPK kinase ( MEK ) and *regulates* EGF stimulated [MEK] and ERK activity . Regulation MAP2K6 IRF3 18198374 1857217 These results indicate that NS3/4A alone or as part of the HCV polyprotein disturbs the expression of IRF1- and *regulated* genes , as well as affecting [mitogen activated protein kinase kinase-] and NF-kappaB regulated genes . Regulation MAP2K6 KDR 14704231 1225446 Localization of and PLD2 in endothelial caveolae is *involved* in VEGF induced phosphorylation of [MEK] and ERK . Regulation MAP2K6 KLF5 17158781 1687894 Thus , *regulates* [MEK/ERK] signaling via EGFR and is also downstream of MAPK signaling , providing a novel mechanism for signal amplification or suppression and control of proliferation in basal cells . Regulation MAP2K6 KRAS 7611406 312117 In conclusion , the activation of MAP kinase by CCK can be explained by activation of [MEK] and may *involve* the activation of by a protein kinase C-dependent mechanism . Regulation MAP2K6 KRAS 8014190 262466 The Raf dependent pathway involves Ras activation , while the Raf independent activation of [MEK] and MAPK does not *involve* . Regulation MAP2K6 KSR1 19091743 2060574 These observations suggest that IMP functions as a threshold modulator , controlling sensitivity of the cascade to stimulus by directly limiting the assembly of functional *dependent* [Raf-MEK] complexes . Regulation MAP2K6 LPA 21832242 2495701 However , inhibition of apical EGFR , but not basolateral EGFR , abrogated induced *regulation* of [MEK] and NHE3 , indicating that LPA ( 5 ) selectively activates apical EGFR . Regulation MAP2K6 MAP2K1 19219045 2044445 The [Mek] heterodimer is negatively *regulated* by Erk mediated phosphorylation of on Thr292 , a residue missing in Mek2 . Regulation MAP2K6 MAP2K7 22353730 2617851 There was no effect of control ASO on expression and MKK7 ASO did not *affect* MKK3 , MKK4 or [MKK6] . Regulation MAP2K6 MAPK1 15064239 1231264 These results suggest that in HTSMCs , LTA stimulated p42/p44 phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , [MEK] , and PI 3-kinase . Regulation MAP2K6 MAPK1 9607326 508494 Pervanadate inhibits [mitogen activated protein kinase kinase-1] in a *dependent* manner . Regulation MAP2K6 MAPK10 15064239 1231265 These results suggest that in HTSMCs , LTA stimulated p42/p44 phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , [MEK] , and PI 3-kinase . Regulation MAP2K6 MAPK10 9607326 508495 Pervanadate inhibits [mitogen activated protein kinase kinase-1] in a *dependent* manner . Regulation MAP2K6 MAPK11 15064239 1231266 These results suggest that in HTSMCs , LTA stimulated p42/p44 phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , [MEK] , and PI 3-kinase . Regulation MAP2K6 MAPK11 9607326 508496 Pervanadate inhibits [mitogen activated protein kinase kinase-1] in a *dependent* manner . Regulation MAP2K6 MAPK12 15064239 1231267 These results suggest that in HTSMCs , LTA stimulated p42/p44 phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , [MEK] , and PI 3-kinase . Regulation MAP2K6 MAPK12 9607326 508497 Pervanadate inhibits [mitogen activated protein kinase kinase-1] in a *dependent* manner . Regulation MAP2K6 MAPK13 15064239 1231268 These results suggest that in HTSMCs , LTA stimulated p42/p44 phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , [MEK] , and PI 3-kinase . Regulation MAP2K6 MAPK13 9607326 508498 Pervanadate inhibits [mitogen activated protein kinase kinase-1] in a *dependent* manner . Regulation MAP2K6 MAPK14 15064239 1231269 These results suggest that in HTSMCs , LTA stimulated p42/p44 phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , [MEK] , and PI 3-kinase . Regulation MAP2K6 MAPK14 9607326 508499 Pervanadate inhibits [mitogen activated protein kinase kinase-1] in a *dependent* manner . Regulation MAP2K6 MAPK15 15064239 1231263 These results suggest that in HTSMCs , LTA stimulated p42/p44 phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , [MEK] , and PI 3-kinase . Regulation MAP2K6 MAPK15 9607326 508493 Pervanadate inhibits [mitogen activated protein kinase kinase-1] in a *dependent* manner . Regulation MAP2K6 MAPK3 15064239 1231270 These results suggest that in HTSMCs , LTA stimulated p42/p44 phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , [MEK] , and PI 3-kinase . Regulation MAP2K6 MAPK3 9607326 508500 Pervanadate inhibits [mitogen activated protein kinase kinase-1] in a *dependent* manner . Regulation MAP2K6 MAPK4 15064239 1231271 These results suggest that in HTSMCs , LTA stimulated p42/p44 phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , [MEK] , and PI 3-kinase . Regulation MAP2K6 MAPK4 9607326 508501 Pervanadate inhibits [mitogen activated protein kinase kinase-1] in a *dependent* manner . Regulation MAP2K6 MAPK6 15064239 1231272 These results suggest that in HTSMCs , LTA stimulated p42/p44 phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , [MEK] , and PI 3-kinase . Regulation MAP2K6 MAPK6 9607326 508502 Pervanadate inhibits [mitogen activated protein kinase kinase-1] in a *dependent* manner . Regulation MAP2K6 MAPK7 15064239 1231273 These results suggest that in HTSMCs , LTA stimulated p42/p44 phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , [MEK] , and PI 3-kinase . Regulation MAP2K6 MAPK7 9607326 508503 Pervanadate inhibits [mitogen activated protein kinase kinase-1] in a *dependent* manner . Regulation MAP2K6 MAPK8 15064239 1231274 These results suggest that in HTSMCs , LTA stimulated p42/p44 phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , [MEK] , and PI 3-kinase . Regulation MAP2K6 MAPK8 9607326 508504 Pervanadate inhibits [mitogen activated protein kinase kinase-1] in a *dependent* manner . Regulation MAP2K6 MAPK9 15064239 1231275 These results suggest that in HTSMCs , LTA stimulated p42/p44 phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , [MEK] , and PI 3-kinase . Regulation MAP2K6 MAPK9 9607326 508505 Pervanadate inhibits [mitogen activated protein kinase kinase-1] in a *dependent* manner . Regulation MAP2K6 MDM2 15723837 1396182 [MEK-ERK] signaling *controls* oncoprotein expression by regulating hdm2 mRNA export to the cytoplasm . Regulation MAP2K6 MKS1 16418722 1561100 Mechanistic studies revealed that TPO stimulation of from lyn ( -/- ) mice did not *affect* phosphorylation of Janus kinase 2 (JAK2) , signal transducer and activator of transcription ( STAT ) 3 , STAT5 , or [MAP kinase kinase (MEK)] . Regulation MAP2K6 MMP9 20413683 2267659 An EGF receptor (EGFR) kinase inhibitor , a RasN17 dominant negative construct , MEK and PI3K inhibitors significantly blocked EGF/EGFR stimulated MMP-9 , cell invasion , and colony formation in U1242 MG cells , suggesting that is *involved* in [EGFR/Ras/MEK] and PI3K/AKT signaling pathway mediated cell invasion and anchorage independent growth in U1242 MG cells . Regulation MAP2K6 MOK 21209080 2391832 We show here that high S100B stimulates murine microglia migration in Boyden chambers via *dependent* activation of Src kinase , Ras , PI3K , [MEK/ERK1/2] , RhoA/ROCK , Rac1/JNK/AP-1 , Rac1/NF-?B , and , to a lesser extent , p38 MAPK . Regulation MAP2K6 MRE11A 11744690 915877 In the same manner , the inhibitory effect of Rap on the activation of p38 by IL-1 occurred at a point downstream of MyD88 , IRAK , and TRAF6 , since the activation of p38 MAPK by these components was inhibited by overexpressing active , while neither MKK3 nor [MKK6] were *affected* . Regulation MAP2K6 NA 11156586 780634 To clarify these issues , we examined the *effect* of on TNF-alpha induced activation of p38 MAP kinase , MAP kinase kinase (MKK) 3 and [MKK6] which are upstream regulators of p38 MAP kinase , and p38 MAP kinase mediated IL-8 production . Regulation MAP2K6 NEDD9 15169888 1253617 Interaction with is required to maintain TPL-2 metabolic stability and also negatively *regulates* TPL-2 [MEK] kinase activity . Regulation MAP2K6 NGF 8529659 336796 Activation of two isoforms of [mitogen activated protein kinase kinase] in *response* to epidermal growth factor and . Regulation MAP2K6 NPPA 8550616 346898 The protein expression of MKP-1 was maximally stimulated by ANP at 120 min. Treatment of the cells with ANP for 120 min resulted in an inhibition of phorbol ester induced activation of MAPK , while the activation of [MEK] was not *affected* by . Regulation MAP2K6 NPY4R 17531083 1746308 BubR1 knockdown via RNAi resulted in enhanced activation of ERKs and MEK in HeLa cells , correlating with inhibition of , a negative *regulator* of [MEK] . Regulation MAP2K6 NRAS 7611406 312118 In conclusion , the activation of MAP kinase by CCK can be explained by activation of [MEK] and may *involve* the activation of by a protein kinase C-dependent mechanism . Regulation MAP2K6 NRAS 8014190 262467 The Raf dependent pathway involves Ras activation , while the Raf independent activation of [MEK] and MAPK does not *involve* . Regulation MAP2K6 NUP43 15064239 1231262 These results suggest that in HTSMCs , LTA stimulated MAPK phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , [MEK] , and PI 3-kinase . Regulation MAP2K6 PARP1 11744690 915875 In the same manner , the inhibitory effect of Rap on the activation of p38 by IL-1 occurred at a point downstream of MyD88 , IRAK , and TRAF6 , since the activation of p38 MAPK by these components was inhibited by overexpressing active , while neither MKK3 nor [MKK6] were *affected* . Regulation MAP2K6 PI3 10958675 724922 Unexpectedly , a CSF-1R lacking the PI3-kinase binding site ( DeltaKI ) remained capable of activating [MEK/ERK] in a *dependent* manner . Regulation MAP2K6 PI3 12502866 1033868 Examination of viral DNA entry suggests a *role* for in HHV-8 entry into the target cells and a role for PKC-zeta , [MEK] , and ERK at a post-viral entry stage of infection . Regulation MAP2K6 PI3 19052921 2053557 The response was abolished by G ( i/o ) and [MEK] inhibition , potentiated by inhibitors of phospholipase C and protein kinase C and did not *involve* activity . Regulation MAP2K6 PIK3CA 18034335 1924462 In summary , the activation of TRPV1 by capsaicin modulates the SP release from DRG neurons via two different mechanisms , one requiring extracellular Ca2+ , the activation of and the IP3 dependent intracellular Ca2+ release , and the other which is independent of extracellular Ca2+ but *involves* the activation of [MEK] . Regulation MAP2K6 PIK3CA 24327733 2880362 *regulates* [MEK/ERK] signaling in breast cancer via the Rac-GEF , P-Rex1 . Regulation MAP2K6 PIK3R1 18034335 1924463 In summary , the activation of TRPV1 by capsaicin modulates the SP release from DRG neurons via two different mechanisms , one requiring extracellular Ca2+ , the activation of and the IP3 dependent intracellular Ca2+ release , and the other which is independent of extracellular Ca2+ but *involves* the activation of [MEK] . Regulation MAP2K6 PIK3R1 24327733 2880363 *regulates* [MEK/ERK] signaling in breast cancer via the Rac-GEF , P-Rex1 . Regulation MAP2K6 PLAU 15874933 1405713 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , [MAP kinase kinase (MKK)3/6] , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Regulation MAP2K6 PLD1 12890486 1117380 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Regulation MAP2K6 PLD2 12890486 1117381 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Regulation MAP2K6 PLD2 14704231 1225447 Localization of VEGFR-2 and in endothelial caveolae is *involved* in VEGF induced phosphorylation of [MEK] and ERK . Regulation MAP2K6 PLD3 12890486 1117376 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Regulation MAP2K6 PLD4 12890486 1117377 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Regulation MAP2K6 PLD5 12890486 1117378 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Regulation MAP2K6 PLD6 12890486 1117379 Localization of Tie2 and in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Regulation MAP2K6 PPP2CA 18272021 1911655 Accordingly , *regulates* acute dose- and time dependent changes in [MEK-ERK-p90RSK] phosphorylation after haloperidol treatment . Regulation MAP2K6 PPP2R1A 18272021 1911656 Accordingly , *regulates* acute dose- and time dependent changes in [MEK-ERK-p90RSK] phosphorylation after haloperidol treatment . Regulation MAP2K6 PPP2R2B 18272021 1911657 Accordingly , *regulates* acute dose- and time dependent changes in [MEK-ERK-p90RSK] phosphorylation after haloperidol treatment . Regulation MAP2K6 PREX1 24327733 2880361 PI3K *regulates* [MEK/ERK] signaling in breast cancer via the Rac-GEF , . Regulation MAP2K6 PRKACB 12130564 966488 Taken together , these results indicate that , under primary culture conditions where physiological levels of signaling proteins are present , hCG signals to activate [MEK] , p42/44 MAPK , CREB , and histone H3 in a predominantly *dependent* and PKC independent manner . Regulation MAP2K6 PRKACB 22819701 2640177 Relaxin induced AKT phosphorylation was G ( i ) - but not *dependent* , and it was blocked by both PI3K and [MEK] inhibitors . Regulation MAP2K6 PRKACG 12130564 966489 Taken together , these results indicate that , under primary culture conditions where physiological levels of signaling proteins are present , hCG signals to activate [MEK] , p42/44 MAPK , CREB , and histone H3 in a predominantly *dependent* and PKC independent manner . Regulation MAP2K6 PRKACG 22819701 2640178 Relaxin induced AKT phosphorylation was G ( i ) - but not *dependent* , and it was blocked by both PI3K and [MEK] inhibitors . Regulation MAP2K6 PRKAR1A 12130564 966490 Taken together , these results indicate that , under primary culture conditions where physiological levels of signaling proteins are present , hCG signals to activate [MEK] , p42/44 MAPK , CREB , and histone H3 in a predominantly *dependent* and PKC independent manner . Regulation MAP2K6 PRKAR1A 22819701 2640179 Relaxin induced AKT phosphorylation was G ( i ) - but not *dependent* , and it was blocked by both PI3K and [MEK] inhibitors . Regulation MAP2K6 PRKAR1B 12130564 966491 Taken together , these results indicate that , under primary culture conditions where physiological levels of signaling proteins are present , hCG signals to activate [MEK] , p42/44 MAPK , CREB , and histone H3 in a predominantly *dependent* and PKC independent manner . Regulation MAP2K6 PRKAR1B 22819701 2640180 Relaxin induced AKT phosphorylation was G ( i ) - but not *dependent* , and it was blocked by both PI3K and [MEK] inhibitors . Regulation MAP2K6 PRKAR2A 12130564 966492 Taken together , these results indicate that , under primary culture conditions where physiological levels of signaling proteins are present , hCG signals to activate [MEK] , p42/44 MAPK , CREB , and histone H3 in a predominantly *dependent* and PKC independent manner . Regulation MAP2K6 PRKAR2A 22819701 2640181 Relaxin induced AKT phosphorylation was G ( i ) - but not *dependent* , and it was blocked by both PI3K and [MEK] inhibitors . Regulation MAP2K6 PRKAR2B 12130564 966493 Taken together , these results indicate that , under primary culture conditions where physiological levels of signaling proteins are present , hCG signals to activate [MEK] , p42/44 MAPK , CREB , and histone H3 in a predominantly *dependent* and PKC independent manner . Regulation MAP2K6 PRKAR2B 22819701 2640182 Relaxin induced AKT phosphorylation was G ( i ) - but not *dependent* , and it was blocked by both PI3K and [MEK] inhibitors . Regulation MAP2K6 PTK2 8649450 364387 However , when signaling through the BCR was bypassed by direct stimulation of the Raf1/MEK/MAPK module via a rise in [ Ca2+ ] i and phorbol ester induced PKC activation , the phosphotransferase activities of Raf1 , [MEK] and MAPK were still regulated in a *dependent* manner that was also partially sensitive to the PTPase inhibitor PAO . Regulation MAP2K6 PTK6 8649450 364388 However , when signaling through the BCR was bypassed by direct stimulation of the Raf1/MEK/MAPK module via a rise in [ Ca2+ ] i and phorbol ester induced PKC activation , the phosphotransferase activities of Raf1 , [MEK] and MAPK were still regulated in a *dependent* manner that was also partially sensitive to the PTPase inhibitor PAO . Regulation MAP2K6 PTK7 8649450 364389 However , when signaling through the BCR was bypassed by direct stimulation of the Raf1/MEK/MAPK module via a rise in [ Ca2+ ] i and phorbol ester induced PKC activation , the phosphotransferase activities of Raf1 , [MEK] and MAPK were still regulated in a *dependent* manner that was also partially sensitive to the PTPase inhibitor PAO . Regulation MAP2K6 PTPN11 16181551 1462003 Both and MKP5 *play* some roles in P2Y receptor mediated activation of [MEK/ERK] , p38 signaling pathways and prostate cancer invasion . Regulation MAP2K6 RAC1 17854274 1810455 [MKK6] phosphorylation *regulates* production of superoxide by enhancing GTPase activity . Regulation MAP2K6 RAC1 22061968 2547684 *regulates* NT3 stimulated [Mek-Erk] signaling , directing marrow isolated adult multilineage inducible ( MIAMI ) cells toward an early neuronal phenotype . Regulation MAP2K6 RAC2 17854274 1810456 [MKK6] phosphorylation *regulates* production of superoxide by enhancing GTPase activity . Regulation MAP2K6 RAC3 17854274 1810457 [MKK6] phosphorylation *regulates* production of superoxide by enhancing GTPase activity . Regulation MAP2K6 RAD50 11744690 915878 In the same manner , the inhibitory effect of Rap on the activation of p38 by IL-1 occurred at a point downstream of MyD88 , IRAK , and TRAF6 , since the activation of p38 MAPK by these components was inhibited by overexpressing active , while neither MKK3 nor [MKK6] were *affected* . Regulation MAP2K6 RAF1 15754006 1380227 , a protein serine-threonine kinase , *plays* a critical role in [mitogen activated protein kinase kinase] ( MKK/MEK ) - mitogen activated protein kinase ( extracellular signal regulated kinase ) ( MAPK/ERK ) pathways . Regulation MAP2K6 RLN1 22819701 2640216 In conclusion , the mitogenic *effect* of in Sertoli cell involves coupling to G ( i ) and activation of both [MEK/ERK1/2] and PI3K/AKT pathways . Regulation MAP2K6 RLN2 22819701 2640217 In conclusion , the mitogenic *effect* of in Sertoli cell involves coupling to G ( i ) and activation of both [MEK/ERK1/2] and PI3K/AKT pathways . Regulation MAP2K6 RLN3 22819701 2640218 In conclusion , the mitogenic *effect* of in Sertoli cell involves coupling to G ( i ) and activation of both [MEK/ERK1/2] and PI3K/AKT pathways . Regulation MAP2K6 SET 15703833 1372711 By contrast , knocking down I-2PP2A/SET by siRNA resulted in enhancement of ERK and MEK activations , suggesting that negatively *regulates* [MEK/ERK] . Regulation MAP2K6 SETD2 22771629 2639562 Notoginsenoside Ft1 promotes angiogenesis via mediated VEGF secretion and the *regulation* of PI3K/AKT and [Raf/MEK/ERK] signaling pathways . Regulation MAP2K6 SFTPC 21081108 2376760 The *effects* of on [Raf/MEK/ERK] and PI3K/Akt signaling were dependent on G ( i/o ) , whereas the SPC induced calcium influx was dependent on G ( q ) . Regulation MAP2K6 SMAD7 12589052 1059845 Transforming growth factor-beta1 ( TGF-beta ) -induced apoptosis of prostate cancer cells involves *dependent* activation of p38 by TGF-beta activated kinase 1 and [mitogen activated protein kinase kinase] 3 . Regulation MAP2K6 SRC 18452714 1926949 Moreover , thrombin stimulated activation of NF-kappaB , AP-1 , and COX-2 promoter activity was blocked by the inhibitors of c-Src , PKC , EGFR , MEK1/2 , AP-1 and NF-kappaB , suggesting that thrombin induces COX-2 promoter activity mediated through PKC ( delta ) *dependent* EGFR transactivation , [MEK-ERK1/2] , AP-1 , and NF-kappaB . Regulation MAP2K6 SRP14 11292597 800972 These results suggest that in the rat , [MEK] inhibition of acid stimulated pancreatic secretion and secretin release *involves* suppression of activity release . Regulation MAP2K6 SRP19 11292597 800973 These results suggest that in the rat , [MEK] inhibition of acid stimulated pancreatic secretion and secretin release *involves* suppression of activity release . Regulation MAP2K6 SRP54 11292597 800974 These results suggest that in the rat , [MEK] inhibition of acid stimulated pancreatic secretion and secretin release *involves* suppression of activity release . Regulation MAP2K6 SRP68 11292597 800975 These results suggest that in the rat , [MEK] inhibition of acid stimulated pancreatic secretion and secretin release *involves* suppression of activity release . Regulation MAP2K6 SRP72 11292597 800976 These results suggest that in the rat , [MEK] inhibition of acid stimulated pancreatic secretion and secretin release *involves* suppression of activity release . Regulation MAP2K6 SRP9 11292597 800977 These results suggest that in the rat , [MEK] inhibition of acid stimulated pancreatic secretion and secretin release *involves* suppression of activity release . Regulation MAP2K6 SST 15659806 1350190 Since basic fibroblast growth factor dependent [MEK] phosphorylation was not *affected* by , we propose a direct effect of SST activated PTPeta on ERK1/2 phosphorylation . Regulation MAP2K6 SYK 9720763 528573 We report that inhibition of PI3K by wortmannin or an inhibitory p85 construct , p85deltaiSH2 , reduced the TCR induced *dependent* activation of Erk2 , as well as the appearance of phospho-Erk and [phospho-Mek] . Regulation MAP2K6 TERF2 11744690 915872 In the same manner , the inhibitory effect of Rap on the activation of p38 by IL-1 occurred at a point downstream of MyD88 , IRAK , and TRAF6 , since the activation of p38 MAPK by these components was inhibited by overexpressing active , while neither MKK3 nor [MKK6] were *affected* . Regulation MAP2K6 TERF2IP 11744690 915874 In the same manner , the inhibitory effect of Rap on the activation of p38 by IL-1 occurred at a point downstream of MyD88 , IRAK , and TRAF6 , since the activation of p38 MAPK by these components was inhibited by overexpressing active , while neither MKK3 nor [MKK6] were *affected* . Regulation MAP2K6 TGFB1 19343212 2057373 Specifically , [MEK-ERK] signaling was dose-dependently induced in *response* to in immortalized cells in vitro and in the A. stephensi midgut epithelium in vivo . Regulation MAP2K6 TGFB2 7957934 278145 In addition , an increased de-novo synthesis of [MAP kinase kinase (MEK)] , the upstream activator of MAP kinase , is observed in *response* to stimulation . Regulation MAP2K6 TIE1 12890486 1117375 Localization of and phospholipase D in endothelial caveolae is *involved* in angiopoietin-1 induced [MEK/ERK] phosphorylation and migration in endothelial cells . Regulation MAP2K6 TLR4 16879219 1593886 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by [MEK/ERK] signaling and NFkappaB activation and that membrane bound CD14 and are *involved* in this mechanism . Regulation MAP2K6 TP53 17126425 1771542 [Raf/MEK/ERK] may promote cell cycle arrest in prostate cells and this may be *regulated* by as restoration of wild-type p53 in p53 deficient prostate cancer cells results in their enhanced sensitivity to chemotherapeutic drugs and increased expression of Raf/MEK/ERK pathway . Regulation MAP2K6 TPO 16418722 1561099 Mechanistic studies revealed that stimulation of MKs from lyn ( -/- ) mice did not *affect* phosphorylation of Janus kinase 2 (JAK2) , signal transducer and activator of transcription ( STAT ) 3 , STAT5 , or [MAP kinase kinase (MEK)] . Regulation MAP2K6 TYR 24158441 2879109 in the kinase domain of the murine kinase suppressor of RAS 1 *regulates* binding and activation of the [mitogen activated protein kinase kinase] . Regulation MAP2K6 VEGFA 10327068 612919 On the other hand , PKC-specific inhibitors severely reduced *dependent* phosphorylation of [MEK] , activation of MAP kinase and subsequent DNA synthesis . Regulation MAP2K6 VEGFA 22771629 2639561 Notoginsenoside Ft1 promotes angiogenesis via HIF-1a mediated secretion and the *regulation* of PI3K/AKT and [Raf/MEK/ERK] signaling pathways . Regulation MAP2K6 XRCC5 11744690 915873 In the same manner , the inhibitory effect of Rap on the activation of p38 by IL-1 occurred at a point downstream of MyD88 , IRAK , and TRAF6 , since the activation of p38 MAPK by these components was inhibited by overexpressing active , while neither MKK3 nor [MKK6] were *affected* . Regulation MAP2K6 XRCC6 11744690 915876 In the same manner , the inhibitory effect of Rap on the activation of p38 by IL-1 occurred at a point downstream of MyD88 , IRAK , and TRAF6 , since the activation of p38 MAPK by these components was inhibited by overexpressing active , while neither MKK3 nor [MKK6] were *affected* . Regulation MAP2K6 YWHAB 19406750 2095674 , an upstream *regulator* of [MEK] , constitutively interacts with residues 1-445 and 446-1250 . Regulation MAP2K7 CD14 16879219 1593889 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by [MEK/ERK] signaling and NFkappaB activation and that membrane bound and TLR-4 are *involved* in this mechanism . Regulation MAP2K7 EPHB2 21077177 2371558 The reduction of EC-SOD and Cu/Zn-SOD was attenuated by pretreatments with GF109203X ( an inhibitor of protein kinase C , PKC ) , diphenyleneiodonium ( an inhibitor of NOX ) , and U0126 ( an inhibitor of mitogen activated protein kinase kinase , [MEK/extracellular-signal] *regulated* kinase , ) . Regulation MAP2K7 EPHB2 22740332 2715465 We conclude that PKC? may regulate [MEK/ERK] and JNK phosphorylation and in turn activated and JNK may *regulate* the proteolytic activity of PDBu induced podosomes by influencing the recruitment of PKC? and MMP-9 to podosomes . Regulation MAP2K7 NEDD9 15169888 1253618 Interaction with is required to maintain TPL-2 metabolic stability and also negatively *regulates* TPL-2 [MEK] kinase activity . Regulation MAP2K7 TNF 17110930 1651030 Moreover , c-FLIPL directly interacts with a JNK activator , MAP kinase kinase (MKK)7 , in a *dependent* manner and inhibits the interactions of [MKK7] with MAP/ERK kinase kinase 1 , apoptosis-signal regulating kinase 1 , and TGFbeta activated kinase 1 . Regulation MAP3K1 PLAU 12493778 1056692 Here we show inducible expression is *controlled* by [MEKK1] , a MAPK kinase kinase that regulates the ERK1/2 and JNK pathways . Regulation MAP3K11 GRIK2 18680160 2011589 Our previous study showed that kainate ( KA ) receptor subunit *played* an important role in ischemia induced [MLK3] and JNK activation and neuronal degeneration through the GluR6-PSD95-MLK3 signaling module . Regulation MAP3K5 CCND1 21187402 2378869 ASK1 overexpression induced the transcription of cyclin D1 , through AP-1 activation , and [ASK1] levels were *regulated* by , via the Rb-E2F pathway . Regulation MAP3K5 CHI3L1 15015934 1251100 The suppressive *effects* of were dependent on phosphoinositide 3-kinase activity , and treatment of cells with HC-gp39 resulted in AKT mediated serine/threonine phosphorylation of [apoptosis signal regulating kinase 1] . Regulation MAP3K5 FAS 11096076 780070 Thus , the antiapoptotic interaction of QRS with [ASK1] is *controlled* positively by the cellular concentration of Gln and negatively by ligation . Regulation MAP3K5 SMN2 21496457 2422956 Collectively , our results suggest that [ASK1] acts as a novel binding partner of SMN and *controls* the steady-state level of through complex formation with SMN in neurite outgrowth . Regulation MAP3K5 TFPI2 11689443 876248 Negative feedback *regulation* of [ASK1] by protein in response to oxidative stress . Regulation MAP3K5 TFPI2 17456047 1766436 These results suggest that PP2Cepsilon maintains ASK1 in an inactive state by dephosphorylation in quiescent cells , supporting the possibility that PP2Cepsilon and *play* different roles in H2O2 induced regulation of [ASK1] activity . Regulation MAP3K5 TNF 15310755 1303556 Taken together , our data suggest that AIP1 is a novel transducer in induced TRAF2 *dependent* activation of [ASK1] that mediates a balance between JNK versus NF-kappaB signaling . Regulation MAP3K5 TNF 19287004 2072959 SHP2 associated with [ASK1] in *response* to in EC . Regulation MAP3K5 TNF 9774977 540127 In untransfected mammalian cells , [ASK1] rapidly associates with TRAF2 in a *dependent* manner . Regulation MAP3K7 EPHB2 14734742 1199428 Of interest , MEKK1 immunoprecipitates from IL-1 stimulated FLS appeared to activate c-Jun through the JNK pathway and [TAK1] activation of c-Jun was *dependent* on JNK , , and p38 . Regulation MAP3K7 IL1B 19232515 2050513 FBXW5 associated with endogenous [TAK1] in an *dependent* manner . Regulation MAP3K7 TNF 10187861 603067 Furthermore , activated endogenous TAK1 , and the kinase negative [TAK1] *acted* as a dominant negative inhibitor against tumor necrosis factor-alpha induced NF-kappaB activation . Regulation MAP3K8 NEDD9 15169888 1253619 Interaction with is required to maintain TPL-2 metabolic stability and also negatively *regulates* [TPL-2] MEK kinase activity . Regulation MAP4K4 TNF 22816003 2634917 Our findings suggest that Aah venom induces insulin resistance by mechanisms involving *dependent* [Map4k4] kinase activation in the adipose tissue . Regulation MAPK1 ADRB2 19047375 2023492 Hematopoietic protein tyrosine phosphatase mediates induced *regulation* of p38 [mitogen activated protein kinase] in B lymphocytes . Regulation MAPK1 ALOX5 21200133 2391703 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Regulation MAPK1 ANGPT1 24308939 2877802 The functional roles of DUSPs in induced *regulation* of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Regulation MAPK1 CD14 12595465 1061547 The LPS receptor complex utilized by the bladder epithelial cell lines included and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 [mitogen activated protein kinase] . Regulation MAPK1 CTGF 19038999 2023101 Interestingly , did not *affect* the BMP-2/CCN2 induced phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Regulation MAPK1 EDN2 12193071 980961 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Regulation MAPK1 EDN2 8632715 357234 *Effects* of on [mitogen activated protein kinase] activity and protein synthesis in isolated adult feline cardiac myocytes . Regulation MAPK1 EPHB2 10207619 606867 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein are regulated by MAPK/ERK kinases (MEKs) and MEKs , in turn , are *regulated* by [MAPK kinase kinases (MAPKKKs)] . Regulation MAPK1 EPHB2 12486127 1056317 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain had little *effect* on basal Erk [MAPK] activation . Regulation MAPK1 EPHB2 12486127 1056344 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [MAPK] *regulation* plays a significant role in axon guidance . Regulation MAPK1 EPHB2 15149321 1248341 PPAR gamma activity is *regulated* by extracellular signal regulated protein kinase ( ERK ) , [mitogen activated protein (MAP) kinase] , and PPAR gamma ligands have varying effects on activity of . Regulation MAPK1 EPHB2 15683363 1395433 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [MAPK] *regulation* . Regulation MAPK1 EPHB2 16098594 1507088 We , previously , showed that PKC *dependent* [MAPK] activation was inhibited by treating the resting B cell line 38B9 with an anti-MHC class II antibody . Regulation MAPK1 EPHB2 17056059 1649536 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Regulation MAPK1 EPHB2 19428358 2077042 The time-course analysis of PA accumulation and [mitogen activated protein kinase (MAPK)] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation MAPK1 FAS 21613257 2454285 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Regulation MAPK1 FHL1 23456229 2781829 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Regulation MAPK1 GPR115 11916960 946012 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK1 GPR115 15555614 1338976 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK1 GPR132 11916960 946001 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK1 GPR132 15555614 1338965 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK1 GPR87 11916960 946081 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK1 GPR87 15555614 1339045 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK1 ID1 23867624 2821335 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and [MAPK] signaling and gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation MAPK1 IL1B 10864897 705692 We therefore investigated the *effects* of TNF-alpha and on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK1 IL1B 10864897 705744 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK1 IL1B 10969830 728495 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Regulation MAPK1 IL1B 11040101 741900 While IL-1 beta phosphorylated c-Jun N-terminus protein kinase (JNK) rapidly and transiently , the *effect* of on p38 [mitogen activated protein kinase (MAPK)] was gradual and persistent . Regulation MAPK1 IL1B 14563491 1154869 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Regulation MAPK1 IL1B 17390080 1716173 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Regulation MAPK1 IL1B 19685010 2186159 The aim of this study was to compare the *effects* of TNF-alpha , and IFN-gamma on the activation of protein kinase B (PKB) , p70 ( S6k ) , [mitogen activated protein kinase (MAPK)] and p90 ( rsk ) , and on IGF-I stimulated glucose uptake and protein synthesis in mouse C2C12 myotubes . Regulation MAPK1 MAP2K6 10471331 641690 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Regulation MAPK1 MAP2K6 11168638 783202 Preincubation of human neutrophils with GF109203X ( an inhibitor of PKC ) , PD98059 ( an inhibitor of , the upstream *regulator* of [ERK1/ERK2] ) or with forskolin or dibutyryl cAMP , failed to suppress proteoglycan degradation of opsonized bovine cartilage . Regulation MAPK1 MAP2K6 11254696 794129 However , analysis of the dynamics of ERK2 and MEK suggested that both of them rapidly shuttle between the cytoplasm and the nucleus and that *regulates* the nuclear shuttling of [ERK2] , whereas MEK remains mainly in the cytoplasm . Regulation MAPK1 MAP2K6 12009309 940886 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Regulation MAPK1 MAP2K6 12637559 1085576 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Regulation MAPK1 MAP2K6 12929129 1132056 The p75 ( NTR ) -induced [MAPK] activation is *dependent* but Raf independent . Regulation MAPK1 MAP2K6 14505338 1144704 The inhibitory *effect* of the inhibitor on [MAPK] phosphorylation was , therefore , suggested to counteract the cytoprotective effects of pro-vitamin C via a thorough interruption of the phosphorylated MAPK signaling pathway . Regulation MAPK1 MAP2K6 15064239 1231297 These results suggest that in HTSMCs , LTA stimulated p42/p44 [MAPK] phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , , and PI 3-kinase . Regulation MAPK1 MAP2K6 8550616 346750 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Regulation MAPK1 MAP2K6 9744865 532674 Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 [MAPK] and its *regulation* by the Ste7 . Regulation MAPK1 MAP2K6 9804770 544436 Furthermore , NE stimulated the expression and secretion of basic fibroblast growth factor (bFGF) , which further promoted the cell survival via *dependent* activation of [Erk1/2] . Regulation MAPK1 PECAM1 18029285 1866931 In contrast , expression of Delta15 in PECAM-1-/- bEND cells had minimal *effects* on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Regulation MAPK1 PGC 20955697 2407039 Finally , inhibition of PPAR? activation by a PPAR? antagonist GW9662 abolished the suppressive *effects* of on p38 [MAPK] phosphorylation and VSMC migration . Regulation MAPK1 PLAU 12759445 1091214 There was no *effect* of on LPS induced activation of p38 [mitogen activated protein kinase] in neutrophils . Regulation MAPK1 PLAU 15874933 1405714 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 [MAPK] , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Regulation MAPK1 RASD1 11751935 921983 Direct *effects* of on the activity of co-expressed , epitope tagged [Erk-2] ( hemagglutinin ( HA ) -Erk-2 ) were measured by immune complex in vitro kinase assay . Regulation MAPK1 SPHK1 20498849 2263721 In addition , our results also unraveled a novel *regulation* of [p38MAPK] by during M. smegmatis infection and generation of NO in macrophages . Regulation MAPK1 TLR7 22109714 2568278 The regulatory effect of complement on signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased [mitogen activated protein kinase] and nuclear factor ?B activation . Regulation MAPK1 TLR7 23979601 2850775 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Regulation MAPK1 TNF 10464169 640322 Therefore , both PI 3-K and p38 [MAPK] signaling pathways *control* production in T cells . Regulation MAPK1 TNF 10864897 705691 We therefore investigated the *effects* of and IL-1beta on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK1 TNF 10864897 705743 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK1 TNF 11689211 876136 The aim of this study was to investigate the expression of the transcription factors Ets-1 , Egr-1 and c-fos in different types of vascular lesions , their *regulation* by and the role of [ERK 1/2] in these signaling events . Regulation MAPK1 TNF 11833090 910319 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of in spleen , and p38 [MAPK] may be *involved* in its signal transduction mechanisms . Regulation MAPK1 TNF 12297009 991060 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Regulation MAPK1 TNF 12297293 991254 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Regulation MAPK1 TNF 12483539 1024802 In addition , PP1 substantially inhibited the IL-2beta- and *dependent* activation of [Erk 1/2] and Akt . Regulation MAPK1 TNF 12543078 1028755 Together , the p43 induced production was *controlled* by NFkB , p38 [MAPK] , and ERK that is dependent on the activities of PLC and PKC . Regulation MAPK1 TNF 14632659 1170631 In the present study , we analysed the *effects* of and 2,4-dinitrochlorobenzene ( DNCB ) on phenotypic maturation and p38 [mitogen activated protein kinase (MAPK)] activity , using a murine DC line . Regulation MAPK1 TNF 15087472 1258140 Stimulatory *effects* of on neuropeptide gene expression and release appeared to be mediated through the type 2 TNF-alpha receptor , and required activation of [ERK 1/2] and p38 , but not Janus kinase , MAPKs . Regulation MAPK1 TNF 15545827 1337967 The results suggest altered *regulation* of Erk 1/2 and p38 [MAPK] signal translation pathways by endogenously produced , or some compound dependent on TNF may modulate , in part , the phosphorylation state of eIF4E in skeletal muscle during sepsis . Regulation MAPK1 TNF 15792609 1386774 *played* a role in induction of Akt and [MAPK] signals in ameloblastoma . Regulation MAPK1 TNF 16081599 1460419 These results indicate that gp120 elicited production by macrophages involves chemokine receptor mediated PI-3K and MAPK activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and [ERK-1/2] independently *regulate* TNF-alpha production . Regulation MAPK1 TNF 16798728 1638543 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Regulation MAPK1 TNF 17031491 1641607 The aim of this study was to investigate the *effects* of stimulation on [MAPK] activation , and the pro- or anti-apoptotic role of these kinases in LNCaP and PC3 cells . Regulation MAPK1 TNF 17074860 1675477 p38 [mitogen activated protein kinase] *controls* NF-kappaB transcriptional activation and alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation MAPK1 TNF 17438131 1742722 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Regulation MAPK1 TNF 19429670 2106823 Then , we examined the *effect* of Ang II and/or on phosphorylation of extracellular signal regulated kinase ( ERK ) , [p38MAPK] , and IkappaB-alpha . Regulation MAPK1 TNF 19648110 2138427 Thus , MKP-1 attenuates *dependent* activation of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Regulation MAPK1 TNF 21949112 2512451 We find that Ga ( i/o ) -mediated activation of the [MAPK] is *independent* of the canonical MyD88 , interleukin-1 receptor associated kinase , and receptor associated factor 6 signaling cascade in LPS stimulated cells . Regulation MAPK1 TNF 22250084 2551221 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Regulation MAPK1 TNF 22988345 2674365 The EGF receptor and HER2 participate in *dependent* [MAPK] activation and IL-8 secretion in intestinal epithelial cells . Regulation MAPK1 TNF 23159491 2729681 Finally , we demonstrate that the transmembrane forms of wild-type and palmitoylation-defective interact differently with TNFR1 and *regulate* NF?B activity , [Erk1/2] phosphorylation and interleukin-6 synthesis differently , strongly suggesting that palmitoylation of TNF is involved in the regulation of TNFR1 signalling . Regulation MAPK1 TNF 23557259 2777858 The p38 MAPK activation and production were *controlled* by p38 [MAPK] and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation MAPK1 TNF 23861542 2817281 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Regulation MAPK1 TNF 24446489 2912947 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Regulation MAPK1 TNF 7636214 317425 To investigate the use of CD120a ( p55 ) and CD120b ( p75 ) in the activation of p42mapk/erk2 in mouse macrophages , we determined the effects of blocking Ab on the activation of [p42mapk/erk2] in *response* to . Regulation MAPK1 TNF 8665940 369030 Cell-permeable ceramide analogs mimicked the *effect* on [MAPK] inhibition and PP-2A activation . Regulation MAPK1 TNF 9439626 482904 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic *effect* of requires protein tyrosine phosphorylation and [MAPK] activation . Regulation MAPK1 TNF 9559646 500217 Here , we have studied the *role* of several receptor associated proteins and caspases in p38 [MAPK] activation by TNF . Regulation MAPK1 TNF 9930718 588846 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Regulation MAPK1 TNF 9931102 588939 To identify which receptor is *involved* in TNF-alpha induced [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Regulation MAPK10 ADRB2 19047375 2023493 Hematopoietic protein tyrosine phosphatase mediates induced *regulation* of p38 [mitogen activated protein kinase] in B lymphocytes . Regulation MAPK10 ALOX5 21200133 2391704 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Regulation MAPK10 ANGPT1 24308939 2877803 The functional roles of DUSPs in induced *regulation* of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Regulation MAPK10 CD14 12595465 1061548 The LPS receptor complex utilized by the bladder epithelial cell lines included and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 [mitogen activated protein kinase] . Regulation MAPK10 CTGF 19038999 2023103 Interestingly , did not *affect* the BMP-2/CCN2 induced phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Regulation MAPK10 EDN2 12193071 980964 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Regulation MAPK10 EDN2 8632715 357237 *Effects* of on [mitogen activated protein kinase] activity and protein synthesis in isolated adult feline cardiac myocytes . Regulation MAPK10 EPHB2 10207619 606868 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein are regulated by MAPK/ERK kinases (MEKs) and MEKs , in turn , are *regulated* by [MAPK kinase kinases (MAPKKKs)] . Regulation MAPK10 EPHB2 12486127 1056318 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain had little *effect* on basal Erk [MAPK] activation . Regulation MAPK10 EPHB2 12486127 1056345 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [MAPK] *regulation* plays a significant role in axon guidance . Regulation MAPK10 EPHB2 15149321 1248342 PPAR gamma activity is *regulated* by extracellular signal regulated protein kinase ( ERK ) , [mitogen activated protein (MAP) kinase] , and PPAR gamma ligands have varying effects on activity of . Regulation MAPK10 EPHB2 15683363 1395434 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [MAPK] *regulation* . Regulation MAPK10 EPHB2 16098594 1507090 We , previously , showed that PKC *dependent* [MAPK] activation was inhibited by treating the resting B cell line 38B9 with an anti-MHC class II antibody . Regulation MAPK10 EPHB2 17056059 1649537 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Regulation MAPK10 EPHB2 19428358 2077043 The time-course analysis of PA accumulation and [mitogen activated protein kinase (MAPK)] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation MAPK10 FAS 21613257 2454286 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Regulation MAPK10 FHL1 23456229 2781830 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Regulation MAPK10 GPR115 11916960 946105 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK10 GPR115 15555614 1339069 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK10 GPR132 11916960 946094 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK10 GPR132 15555614 1339058 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK10 GPR87 11916960 946174 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK10 GPR87 15555614 1339138 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK10 ID1 23867624 2821336 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and [MAPK] signaling and gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation MAPK10 IL1B 10864897 705694 We therefore investigated the *effects* of TNF-alpha and on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK10 IL1B 10864897 705746 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK10 IL1B 10969830 728496 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Regulation MAPK10 IL1B 11040101 741901 While IL-1 beta phosphorylated c-Jun N-terminus protein kinase (JNK) rapidly and transiently , the *effect* of on p38 [mitogen activated protein kinase (MAPK)] was gradual and persistent . Regulation MAPK10 IL1B 14563491 1154870 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Regulation MAPK10 IL1B 17390080 1716174 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Regulation MAPK10 IL1B 19685010 2186161 The aim of this study was to compare the *effects* of TNF-alpha , and IFN-gamma on the activation of protein kinase B (PKB) , p70 ( S6k ) , [mitogen activated protein kinase (MAPK)] and p90 ( rsk ) , and on IGF-I stimulated glucose uptake and protein synthesis in mouse C2C12 myotubes . Regulation MAPK10 MAP2K6 10471331 641697 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Regulation MAPK10 MAP2K6 12009309 940893 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Regulation MAPK10 MAP2K6 12637559 1085586 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Regulation MAPK10 MAP2K6 12929129 1132063 The p75 ( NTR ) -induced [MAPK] activation is *dependent* but Raf independent . Regulation MAPK10 MAP2K6 14505338 1144711 The inhibitory *effect* of the inhibitor on [MAPK] phosphorylation was , therefore , suggested to counteract the cytoprotective effects of pro-vitamin C via a thorough interruption of the phosphorylated MAPK signaling pathway . Regulation MAPK10 MAP2K6 15064239 1231306 These results suggest that in HTSMCs , LTA stimulated p42/p44 [MAPK] phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , , and PI 3-kinase . Regulation MAPK10 MAP2K6 8550616 346758 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Regulation MAPK10 MAP2K6 9744865 532681 Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 [MAPK] and its *regulation* by the Ste7 . Regulation MAPK10 PECAM1 18029285 1866932 In contrast , expression of Delta15 in PECAM-1-/- bEND cells had minimal *effects* on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Regulation MAPK10 PGC 20955697 2407040 Finally , inhibition of PPAR? activation by a PPAR? antagonist GW9662 abolished the suppressive *effects* of on p38 [MAPK] phosphorylation and VSMC migration . Regulation MAPK10 PLAU 12759445 1091215 There was no *effect* of on LPS induced activation of p38 [mitogen activated protein kinase] in neutrophils . Regulation MAPK10 PLAU 15874933 1405715 Activation of the [mitogen activated protein kinases (MAPK)] , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Regulation MAPK10 SPHK1 20498849 2263722 In addition , our results also unraveled a novel *regulation* of [p38MAPK] by during M. smegmatis infection and generation of NO in macrophages . Regulation MAPK10 TLR7 22109714 2568288 The regulatory effect of complement on signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased [mitogen activated protein kinase] and nuclear factor ?B activation . Regulation MAPK10 TLR7 23979601 2850785 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Regulation MAPK10 TNF 10464169 640323 Therefore , both PI 3-K and p38 [MAPK] signaling pathways *control* production in T cells . Regulation MAPK10 TNF 10864897 705693 We therefore investigated the *effects* of and IL-1beta on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK10 TNF 10864897 705745 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK10 TNF 11833090 910320 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of in spleen , and p38 [MAPK] may be *involved* in its signal transduction mechanisms . Regulation MAPK10 TNF 12297009 991061 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Regulation MAPK10 TNF 12297293 991255 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Regulation MAPK10 TNF 12543078 1028756 Together , the p43 induced production was *controlled* by NFkB , p38 [MAPK] , and ERK that is dependent on the activities of PLC and PKC . Regulation MAPK10 TNF 14632659 1170632 In the present study , we analysed the *effects* of and 2,4-dinitrochlorobenzene ( DNCB ) on phenotypic maturation and p38 [mitogen activated protein kinase (MAPK)] activity , using a murine DC line . Regulation MAPK10 TNF 15545827 1337968 The results suggest altered *regulation* of Erk 1/2 and p38 [MAPK] signal translation pathways by endogenously produced , or some compound dependent on TNF may modulate , in part , the phosphorylation state of eIF4E in skeletal muscle during sepsis . Regulation MAPK10 TNF 15792609 1386775 *played* a role in induction of Akt and [MAPK] signals in ameloblastoma . Regulation MAPK10 TNF 16798728 1638544 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Regulation MAPK10 TNF 17031491 1641608 The aim of this study was to investigate the *effects* of stimulation on [MAPK] activation , and the pro- or anti-apoptotic role of these kinases in LNCaP and PC3 cells . Regulation MAPK10 TNF 17074860 1675480 p38 [mitogen activated protein kinase] *controls* NF-kappaB transcriptional activation and alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation MAPK10 TNF 17438131 1742723 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Regulation MAPK10 TNF 19429670 2106825 Then , we examined the *effect* of Ang II and/or on phosphorylation of extracellular signal regulated kinase ( ERK ) , [p38MAPK] , and IkappaB-alpha . Regulation MAPK10 TNF 19648110 2138428 Thus , MKP-1 attenuates *dependent* activation of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Regulation MAPK10 TNF 21949112 2512457 We find that Ga ( i/o ) -mediated activation of the [MAPK] is *independent* of the canonical MyD88 , interleukin-1 receptor associated kinase , and receptor associated factor 6 signaling cascade in LPS stimulated cells . Regulation MAPK10 TNF 22250084 2551223 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Regulation MAPK10 TNF 22988345 2674366 The EGF receptor and HER2 participate in *dependent* [MAPK] activation and IL-8 secretion in intestinal epithelial cells . Regulation MAPK10 TNF 23557259 2777861 The p38 MAPK activation and production were *controlled* by p38 [MAPK] and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation MAPK10 TNF 23861542 2817282 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Regulation MAPK10 TNF 24446489 2912948 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Regulation MAPK10 TNF 8665940 369031 Cell-permeable ceramide analogs mimicked the *effect* on [MAPK] inhibition and PP-2A activation . Regulation MAPK10 TNF 9439626 482905 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic *effect* of requires protein tyrosine phosphorylation and [MAPK] activation . Regulation MAPK10 TNF 9559646 500218 Here , we have studied the *role* of several receptor associated proteins and caspases in p38 [MAPK] activation by TNF . Regulation MAPK10 TNF 9930718 588847 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Regulation MAPK10 TNF 9931102 588940 To identify which receptor is *involved* in TNF-alpha induced [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Regulation MAPK11 ADRB2 19047375 2023494 Hematopoietic protein tyrosine phosphatase mediates induced *regulation* of p38 [mitogen activated protein kinase] in B lymphocytes . Regulation MAPK11 ALOX5 21200133 2391705 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Regulation MAPK11 ANGPT1 24308939 2877804 The functional roles of DUSPs in induced *regulation* of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Regulation MAPK11 CD14 12595465 1061549 The LPS receptor complex utilized by the bladder epithelial cell lines included and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 [mitogen activated protein kinase] . Regulation MAPK11 CTGF 19038999 2023105 Interestingly , did not *affect* the BMP-2/CCN2 induced phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Regulation MAPK11 EDN2 12193071 980967 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Regulation MAPK11 EDN2 8632715 357240 *Effects* of on [mitogen activated protein kinase] activity and protein synthesis in isolated adult feline cardiac myocytes . Regulation MAPK11 EPHB2 10207619 606869 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein are regulated by MAPK/ERK kinases (MEKs) and MEKs , in turn , are *regulated* by [MAPK kinase kinases (MAPKKKs)] . Regulation MAPK11 EPHB2 12486127 1056319 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain had little *effect* on basal Erk [MAPK] activation . Regulation MAPK11 EPHB2 12486127 1056346 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [MAPK] *regulation* plays a significant role in axon guidance . Regulation MAPK11 EPHB2 15149321 1248343 PPAR gamma activity is *regulated* by extracellular signal regulated protein kinase ( ERK ) , [mitogen activated protein (MAP) kinase] , and PPAR gamma ligands have varying effects on activity of . Regulation MAPK11 EPHB2 15683363 1395435 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [MAPK] *regulation* . Regulation MAPK11 EPHB2 16098594 1507092 We , previously , showed that PKC *dependent* [MAPK] activation was inhibited by treating the resting B cell line 38B9 with an anti-MHC class II antibody . Regulation MAPK11 EPHB2 17056059 1649538 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Regulation MAPK11 EPHB2 19428358 2077044 The time-course analysis of PA accumulation and [mitogen activated protein kinase (MAPK)] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation MAPK11 FAS 21613257 2454287 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Regulation MAPK11 FHL1 23456229 2781831 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Regulation MAPK11 GPR115 11916960 946198 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK11 GPR115 15555614 1339162 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK11 GPR132 11916960 946187 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK11 GPR132 15555614 1339151 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK11 GPR87 11916960 946267 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK11 GPR87 15555614 1339231 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK11 ID1 23867624 2821337 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and [MAPK] signaling and gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation MAPK11 IL1B 10864897 705696 We therefore investigated the *effects* of TNF-alpha and on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK11 IL1B 10864897 705748 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK11 IL1B 10969830 728497 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Regulation MAPK11 IL1B 11040101 741902 While IL-1 beta phosphorylated c-Jun N-terminus protein kinase (JNK) rapidly and transiently , the *effect* of on p38 [mitogen activated protein kinase (MAPK)] was gradual and persistent . Regulation MAPK11 IL1B 14563491 1154871 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Regulation MAPK11 IL1B 17390080 1716175 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Regulation MAPK11 IL1B 19685010 2186163 The aim of this study was to compare the *effects* of TNF-alpha , and IFN-gamma on the activation of protein kinase B (PKB) , p70 ( S6k ) , [mitogen activated protein kinase (MAPK)] and p90 ( rsk ) , and on IGF-I stimulated glucose uptake and protein synthesis in mouse C2C12 myotubes . Regulation MAPK11 MAP2K6 10471331 641704 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Regulation MAPK11 MAP2K6 12009309 940900 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Regulation MAPK11 MAP2K6 12637559 1085596 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Regulation MAPK11 MAP2K6 12929129 1132070 The p75 ( NTR ) -induced [MAPK] activation is *dependent* but Raf independent . Regulation MAPK11 MAP2K6 14505338 1144718 The inhibitory *effect* of the inhibitor on [MAPK] phosphorylation was , therefore , suggested to counteract the cytoprotective effects of pro-vitamin C via a thorough interruption of the phosphorylated MAPK signaling pathway . Regulation MAPK11 MAP2K6 15064239 1231315 These results suggest that in HTSMCs , LTA stimulated p42/p44 [MAPK] phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , , and PI 3-kinase . Regulation MAPK11 MAP2K6 8550616 346766 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Regulation MAPK11 MAP2K6 9744865 532688 Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 [MAPK] and its *regulation* by the Ste7 . Regulation MAPK11 PECAM1 18029285 1866933 In contrast , expression of Delta15 in PECAM-1-/- bEND cells had minimal *effects* on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Regulation MAPK11 PGC 20955697 2407041 Finally , inhibition of PPAR? activation by a PPAR? antagonist GW9662 abolished the suppressive *effects* of on p38 [MAPK] phosphorylation and VSMC migration . Regulation MAPK11 PLAU 12759445 1091216 There was no *effect* of on LPS induced activation of p38 [mitogen activated protein kinase] in neutrophils . Regulation MAPK11 PLAU 15874933 1405716 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 [MAPK] , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Regulation MAPK11 SPHK1 20498849 2263723 In addition , our results also unraveled a novel *regulation* of [p38MAPK] by during M. smegmatis infection and generation of NO in macrophages . Regulation MAPK11 TLR7 22109714 2568298 The regulatory effect of complement on signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased [mitogen activated protein kinase] and nuclear factor ?B activation . Regulation MAPK11 TLR7 23979601 2850795 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Regulation MAPK11 TNF 10464169 640324 Therefore , both PI 3-K and p38 [MAPK] signaling pathways *control* production in T cells . Regulation MAPK11 TNF 10864897 705695 We therefore investigated the *effects* of and IL-1beta on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK11 TNF 10864897 705747 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK11 TNF 11833090 910321 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of in spleen , and p38 [MAPK] may be *involved* in its signal transduction mechanisms . Regulation MAPK11 TNF 12297009 991062 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Regulation MAPK11 TNF 12297293 991256 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Regulation MAPK11 TNF 12543078 1028757 Together , the p43 induced production was *controlled* by NFkB , p38 [MAPK] , and ERK that is dependent on the activities of PLC and PKC . Regulation MAPK11 TNF 14632659 1170633 In the present study , we analysed the *effects* of and 2,4-dinitrochlorobenzene ( DNCB ) on phenotypic maturation and p38 [mitogen activated protein kinase (MAPK)] activity , using a murine DC line . Regulation MAPK11 TNF 15545827 1337969 The results suggest altered *regulation* of Erk 1/2 and p38 [MAPK] signal translation pathways by endogenously produced , or some compound dependent on TNF may modulate , in part , the phosphorylation state of eIF4E in skeletal muscle during sepsis . Regulation MAPK11 TNF 15792609 1386776 *played* a role in induction of Akt and [MAPK] signals in ameloblastoma . Regulation MAPK11 TNF 16798728 1638545 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Regulation MAPK11 TNF 17031491 1641609 The aim of this study was to investigate the *effects* of stimulation on [MAPK] activation , and the pro- or anti-apoptotic role of these kinases in LNCaP and PC3 cells . Regulation MAPK11 TNF 17074860 1675483 p38 [mitogen activated protein kinase] *controls* NF-kappaB transcriptional activation and alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation MAPK11 TNF 17438131 1742724 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Regulation MAPK11 TNF 19429670 2106827 Then , we examined the *effect* of Ang II and/or on phosphorylation of extracellular signal regulated kinase ( ERK ) , [p38MAPK] , and IkappaB-alpha . Regulation MAPK11 TNF 19648110 2138429 Thus , MKP-1 attenuates *dependent* activation of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Regulation MAPK11 TNF 21949112 2512463 We find that Ga ( i/o ) -mediated activation of the [MAPK] is *independent* of the canonical MyD88 , interleukin-1 receptor associated kinase , and receptor associated factor 6 signaling cascade in LPS stimulated cells . Regulation MAPK11 TNF 22250084 2551225 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Regulation MAPK11 TNF 22988345 2674367 The EGF receptor and HER2 participate in *dependent* [MAPK] activation and IL-8 secretion in intestinal epithelial cells . Regulation MAPK11 TNF 23557259 2777864 The p38 MAPK activation and production were *controlled* by p38 [MAPK] and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation MAPK11 TNF 23861542 2817283 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Regulation MAPK11 TNF 24446489 2912949 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Regulation MAPK11 TNF 8665940 369032 Cell-permeable ceramide analogs mimicked the *effect* on [MAPK] inhibition and PP-2A activation . Regulation MAPK11 TNF 9439626 482906 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic *effect* of requires protein tyrosine phosphorylation and [MAPK] activation . Regulation MAPK11 TNF 9559646 500219 Here , we have studied the *role* of several receptor associated proteins and caspases in p38 [MAPK] activation by TNF . Regulation MAPK11 TNF 9930718 588848 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Regulation MAPK11 TNF 9931102 588941 To identify which receptor is *involved* in TNF-alpha induced [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Regulation MAPK12 ADRB2 19047375 2023495 Hematopoietic protein tyrosine phosphatase mediates induced *regulation* of p38 [mitogen activated protein kinase] in B lymphocytes . Regulation MAPK12 ALOX5 21200133 2391706 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Regulation MAPK12 ANGPT1 24308939 2877805 The functional roles of DUSPs in induced *regulation* of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Regulation MAPK12 CD14 12595465 1061550 The LPS receptor complex utilized by the bladder epithelial cell lines included and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 [mitogen activated protein kinase] . Regulation MAPK12 CTGF 19038999 2023107 Interestingly , did not *affect* the BMP-2/CCN2 induced phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Regulation MAPK12 EDN2 12193071 980970 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Regulation MAPK12 EDN2 8632715 357243 *Effects* of on [mitogen activated protein kinase] activity and protein synthesis in isolated adult feline cardiac myocytes . Regulation MAPK12 EPHB2 10207619 606870 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein are regulated by MAPK/ERK kinases (MEKs) and MEKs , in turn , are *regulated* by [MAPK kinase kinases (MAPKKKs)] . Regulation MAPK12 EPHB2 12486127 1056320 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain had little *effect* on basal Erk [MAPK] activation . Regulation MAPK12 EPHB2 12486127 1056347 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [MAPK] *regulation* plays a significant role in axon guidance . Regulation MAPK12 EPHB2 15149321 1248344 PPAR gamma activity is *regulated* by extracellular signal regulated protein kinase ( ERK ) , [mitogen activated protein (MAP) kinase] , and PPAR gamma ligands have varying effects on activity of . Regulation MAPK12 EPHB2 15683363 1395436 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [MAPK] *regulation* . Regulation MAPK12 EPHB2 16098594 1507094 We , previously , showed that PKC *dependent* [MAPK] activation was inhibited by treating the resting B cell line 38B9 with an anti-MHC class II antibody . Regulation MAPK12 EPHB2 17056059 1649539 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Regulation MAPK12 EPHB2 19428358 2077045 The time-course analysis of PA accumulation and [mitogen activated protein kinase (MAPK)] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation MAPK12 FAS 21613257 2454288 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Regulation MAPK12 FHL1 23456229 2781832 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Regulation MAPK12 GPR115 11916960 946291 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK12 GPR115 15555614 1339255 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK12 GPR132 11916960 946280 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK12 GPR132 15555614 1339244 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK12 GPR87 11916960 946360 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK12 GPR87 15555614 1339324 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK12 ID1 23867624 2821338 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and [MAPK] signaling and gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation MAPK12 IL1B 10864897 705698 We therefore investigated the *effects* of TNF-alpha and on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK12 IL1B 10864897 705750 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK12 IL1B 10969830 728498 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Regulation MAPK12 IL1B 11040101 741903 While IL-1 beta phosphorylated c-Jun N-terminus protein kinase (JNK) rapidly and transiently , the *effect* of on p38 [mitogen activated protein kinase (MAPK)] was gradual and persistent . Regulation MAPK12 IL1B 14563491 1154872 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Regulation MAPK12 IL1B 17390080 1716176 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Regulation MAPK12 IL1B 19685010 2186165 The aim of this study was to compare the *effects* of TNF-alpha , and IFN-gamma on the activation of protein kinase B (PKB) , p70 ( S6k ) , [mitogen activated protein kinase (MAPK)] and p90 ( rsk ) , and on IGF-I stimulated glucose uptake and protein synthesis in mouse C2C12 myotubes . Regulation MAPK12 MAP2K6 10471331 641711 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Regulation MAPK12 MAP2K6 12009309 940907 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Regulation MAPK12 MAP2K6 12637559 1085606 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Regulation MAPK12 MAP2K6 12929129 1132077 The p75 ( NTR ) -induced [MAPK] activation is *dependent* but Raf independent . Regulation MAPK12 MAP2K6 14505338 1144725 The inhibitory *effect* of the inhibitor on [MAPK] phosphorylation was , therefore , suggested to counteract the cytoprotective effects of pro-vitamin C via a thorough interruption of the phosphorylated MAPK signaling pathway . Regulation MAPK12 MAP2K6 15064239 1231324 These results suggest that in HTSMCs , LTA stimulated p42/p44 [MAPK] phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , , and PI 3-kinase . Regulation MAPK12 MAP2K6 8550616 346774 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Regulation MAPK12 MAP2K6 9744865 532695 Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 [MAPK] and its *regulation* by the Ste7 . Regulation MAPK12 PECAM1 18029285 1866934 In contrast , expression of Delta15 in PECAM-1-/- bEND cells had minimal *effects* on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Regulation MAPK12 PGC 20955697 2407042 Finally , inhibition of PPAR? activation by a PPAR? antagonist GW9662 abolished the suppressive *effects* of on p38 [MAPK] phosphorylation and VSMC migration . Regulation MAPK12 PLAU 12759445 1091217 There was no *effect* of on LPS induced activation of p38 [mitogen activated protein kinase] in neutrophils . Regulation MAPK12 PLAU 15874933 1405717 Activation of the [mitogen activated protein kinases (MAPK)] , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Regulation MAPK12 SPHK1 20498849 2263724 In addition , our results also unraveled a novel *regulation* of [p38MAPK] by during M. smegmatis infection and generation of NO in macrophages . Regulation MAPK12 TLR7 22109714 2568308 The regulatory effect of complement on signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased [mitogen activated protein kinase] and nuclear factor ?B activation . Regulation MAPK12 TLR7 23979601 2850805 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Regulation MAPK12 TNF 10464169 640325 Therefore , both PI 3-K and p38 [MAPK] signaling pathways *control* production in T cells . Regulation MAPK12 TNF 10864897 705697 We therefore investigated the *effects* of and IL-1beta on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK12 TNF 10864897 705749 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK12 TNF 11833090 910322 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of in spleen , and p38 [MAPK] may be *involved* in its signal transduction mechanisms . Regulation MAPK12 TNF 12297009 991063 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Regulation MAPK12 TNF 12297293 991257 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Regulation MAPK12 TNF 12543078 1028758 Together , the p43 induced production was *controlled* by NFkB , p38 [MAPK] , and ERK that is dependent on the activities of PLC and PKC . Regulation MAPK12 TNF 14632659 1170634 In the present study , we analysed the *effects* of and 2,4-dinitrochlorobenzene ( DNCB ) on phenotypic maturation and p38 [mitogen activated protein kinase (MAPK)] activity , using a murine DC line . Regulation MAPK12 TNF 15545827 1337970 The results suggest altered *regulation* of Erk 1/2 and p38 [MAPK] signal translation pathways by endogenously produced , or some compound dependent on TNF may modulate , in part , the phosphorylation state of eIF4E in skeletal muscle during sepsis . Regulation MAPK12 TNF 15792609 1386777 *played* a role in induction of Akt and [MAPK] signals in ameloblastoma . Regulation MAPK12 TNF 16798728 1638546 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Regulation MAPK12 TNF 17031491 1641610 The aim of this study was to investigate the *effects* of stimulation on [MAPK] activation , and the pro- or anti-apoptotic role of these kinases in LNCaP and PC3 cells . Regulation MAPK12 TNF 17074860 1675486 p38 [mitogen activated protein kinase] *controls* NF-kappaB transcriptional activation and alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation MAPK12 TNF 17438131 1742725 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Regulation MAPK12 TNF 19429670 2106829 Then , we examined the *effect* of Ang II and/or on phosphorylation of extracellular signal regulated kinase ( ERK ) , [p38MAPK] , and IkappaB-alpha . Regulation MAPK12 TNF 19648110 2138430 Thus , MKP-1 attenuates *dependent* activation of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Regulation MAPK12 TNF 21949112 2512469 We find that Ga ( i/o ) -mediated activation of the [MAPK] is *independent* of the canonical MyD88 , interleukin-1 receptor associated kinase , and receptor associated factor 6 signaling cascade in LPS stimulated cells . Regulation MAPK12 TNF 22250084 2551227 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Regulation MAPK12 TNF 22988345 2674368 The EGF receptor and HER2 participate in *dependent* [MAPK] activation and IL-8 secretion in intestinal epithelial cells . Regulation MAPK12 TNF 23557259 2777867 The p38 MAPK activation and production were *controlled* by p38 [MAPK] and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation MAPK12 TNF 23861542 2817284 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Regulation MAPK12 TNF 24446489 2912950 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Regulation MAPK12 TNF 8665940 369033 Cell-permeable ceramide analogs mimicked the *effect* on [MAPK] inhibition and PP-2A activation . Regulation MAPK12 TNF 9439626 482907 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic *effect* of requires protein tyrosine phosphorylation and [MAPK] activation . Regulation MAPK12 TNF 9559646 500220 Here , we have studied the *role* of several receptor associated proteins and caspases in p38 [MAPK] activation by TNF . Regulation MAPK12 TNF 9930718 588849 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Regulation MAPK12 TNF 9931102 588942 To identify which receptor is *involved* in TNF-alpha induced [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Regulation MAPK13 ADRB2 19047375 2023496 Hematopoietic protein tyrosine phosphatase mediates induced *regulation* of p38 [mitogen activated protein kinase] in B lymphocytes . Regulation MAPK13 ALOX5 21200133 2391707 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Regulation MAPK13 ANGPT1 24308939 2877806 The functional roles of DUSPs in induced *regulation* of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Regulation MAPK13 CD14 12595465 1061551 The LPS receptor complex utilized by the bladder epithelial cell lines included and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 [mitogen activated protein kinase] . Regulation MAPK13 CTGF 19038999 2023109 Interestingly , did not *affect* the BMP-2/CCN2 induced phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Regulation MAPK13 EDN2 12193071 980973 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Regulation MAPK13 EDN2 8632715 357246 *Effects* of on [mitogen activated protein kinase] activity and protein synthesis in isolated adult feline cardiac myocytes . Regulation MAPK13 EPHB2 10207619 606871 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein are regulated by MAPK/ERK kinases (MEKs) and MEKs , in turn , are *regulated* by [MAPK kinase kinases (MAPKKKs)] . Regulation MAPK13 EPHB2 12486127 1056321 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain had little *effect* on basal Erk [MAPK] activation . Regulation MAPK13 EPHB2 12486127 1056348 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [MAPK] *regulation* plays a significant role in axon guidance . Regulation MAPK13 EPHB2 15149321 1248345 PPAR gamma activity is *regulated* by extracellular signal regulated protein kinase ( ERK ) , [mitogen activated protein (MAP) kinase] , and PPAR gamma ligands have varying effects on activity of . Regulation MAPK13 EPHB2 15683363 1395437 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [MAPK] *regulation* . Regulation MAPK13 EPHB2 16098594 1507096 We , previously , showed that PKC *dependent* [MAPK] activation was inhibited by treating the resting B cell line 38B9 with an anti-MHC class II antibody . Regulation MAPK13 EPHB2 17056059 1649540 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Regulation MAPK13 EPHB2 19428358 2077046 The time-course analysis of PA accumulation and [mitogen activated protein kinase (MAPK)] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation MAPK13 FAS 21613257 2454289 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Regulation MAPK13 FHL1 23456229 2781833 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Regulation MAPK13 GPR115 11916960 946384 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK13 GPR115 15555614 1339348 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK13 GPR132 11916960 946373 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK13 GPR132 15555614 1339337 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK13 GPR87 11916960 946453 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK13 GPR87 15555614 1339417 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK13 ID1 23867624 2821339 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and [MAPK] signaling and gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation MAPK13 IL1B 10864897 705700 We therefore investigated the *effects* of TNF-alpha and on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK13 IL1B 10864897 705752 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK13 IL1B 10969830 728499 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Regulation MAPK13 IL1B 11040101 741904 While IL-1 beta phosphorylated c-Jun N-terminus protein kinase (JNK) rapidly and transiently , the *effect* of on p38 [mitogen activated protein kinase (MAPK)] was gradual and persistent . Regulation MAPK13 IL1B 14563491 1154873 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Regulation MAPK13 IL1B 17390080 1716177 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Regulation MAPK13 IL1B 19685010 2186167 The aim of this study was to compare the *effects* of TNF-alpha , and IFN-gamma on the activation of protein kinase B (PKB) , p70 ( S6k ) , [mitogen activated protein kinase (MAPK)] and p90 ( rsk ) , and on IGF-I stimulated glucose uptake and protein synthesis in mouse C2C12 myotubes . Regulation MAPK13 MAP2K6 10471331 641718 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Regulation MAPK13 MAP2K6 12009309 940914 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Regulation MAPK13 MAP2K6 12637559 1085616 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Regulation MAPK13 MAP2K6 12929129 1132084 The p75 ( NTR ) -induced [MAPK] activation is *dependent* but Raf independent . Regulation MAPK13 MAP2K6 14505338 1144732 The inhibitory *effect* of the inhibitor on [MAPK] phosphorylation was , therefore , suggested to counteract the cytoprotective effects of pro-vitamin C via a thorough interruption of the phosphorylated MAPK signaling pathway . Regulation MAPK13 MAP2K6 15064239 1231333 These results suggest that in HTSMCs , LTA stimulated p42/p44 [MAPK] phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , , and PI 3-kinase . Regulation MAPK13 MAP2K6 8550616 346782 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Regulation MAPK13 MAP2K6 9744865 532702 Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 [MAPK] and its *regulation* by the Ste7 . Regulation MAPK13 PECAM1 18029285 1866935 In contrast , expression of Delta15 in PECAM-1-/- bEND cells had minimal *effects* on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Regulation MAPK13 PGC 20955697 2407043 Finally , inhibition of PPAR? activation by a PPAR? antagonist GW9662 abolished the suppressive *effects* of on p38 [MAPK] phosphorylation and VSMC migration . Regulation MAPK13 PLAU 12759445 1091218 There was no *effect* of on LPS induced activation of p38 [mitogen activated protein kinase] in neutrophils . Regulation MAPK13 PLAU 15874933 1405718 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 [MAPK] , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Regulation MAPK13 SPHK1 20498849 2263725 In addition , our results also unraveled a novel *regulation* of [p38MAPK] by during M. smegmatis infection and generation of NO in macrophages . Regulation MAPK13 TLR7 22109714 2568318 The regulatory effect of complement on signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased [mitogen activated protein kinase] and nuclear factor ?B activation . Regulation MAPK13 TLR7 23979601 2850815 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Regulation MAPK13 TNF 10464169 640326 Therefore , both PI 3-K and p38 [MAPK] signaling pathways *control* production in T cells . Regulation MAPK13 TNF 10864897 705699 We therefore investigated the *effects* of and IL-1beta on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK13 TNF 10864897 705751 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK13 TNF 11833090 910323 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of in spleen , and p38 [MAPK] may be *involved* in its signal transduction mechanisms . Regulation MAPK13 TNF 12297009 991064 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Regulation MAPK13 TNF 12297293 991258 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Regulation MAPK13 TNF 12543078 1028759 Together , the p43 induced production was *controlled* by NFkB , p38 [MAPK] , and ERK that is dependent on the activities of PLC and PKC . Regulation MAPK13 TNF 14632659 1170635 In the present study , we analysed the *effects* of and 2,4-dinitrochlorobenzene ( DNCB ) on phenotypic maturation and p38 [mitogen activated protein kinase (MAPK)] activity , using a murine DC line . Regulation MAPK13 TNF 15545827 1337971 The results suggest altered *regulation* of Erk 1/2 and p38 [MAPK] signal translation pathways by endogenously produced , or some compound dependent on TNF may modulate , in part , the phosphorylation state of eIF4E in skeletal muscle during sepsis . Regulation MAPK13 TNF 15792609 1386778 *played* a role in induction of Akt and [MAPK] signals in ameloblastoma . Regulation MAPK13 TNF 16798728 1638547 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Regulation MAPK13 TNF 17031491 1641611 The aim of this study was to investigate the *effects* of stimulation on [MAPK] activation , and the pro- or anti-apoptotic role of these kinases in LNCaP and PC3 cells . Regulation MAPK13 TNF 17074860 1675489 p38 [mitogen activated protein kinase] *controls* NF-kappaB transcriptional activation and alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation MAPK13 TNF 17438131 1742726 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Regulation MAPK13 TNF 19429670 2106831 Then , we examined the *effect* of Ang II and/or on phosphorylation of extracellular signal regulated kinase ( ERK ) , [p38MAPK] , and IkappaB-alpha . Regulation MAPK13 TNF 19648110 2138431 Thus , MKP-1 attenuates *dependent* activation of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Regulation MAPK13 TNF 21949112 2512475 We find that Ga ( i/o ) -mediated activation of the [MAPK] is *independent* of the canonical MyD88 , interleukin-1 receptor associated kinase , and receptor associated factor 6 signaling cascade in LPS stimulated cells . Regulation MAPK13 TNF 22250084 2551229 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Regulation MAPK13 TNF 22988345 2674369 The EGF receptor and HER2 participate in *dependent* [MAPK] activation and IL-8 secretion in intestinal epithelial cells . Regulation MAPK13 TNF 23557259 2777870 The p38 MAPK activation and production were *controlled* by p38 [MAPK] and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation MAPK13 TNF 23861542 2817285 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Regulation MAPK13 TNF 24446489 2912951 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Regulation MAPK13 TNF 8665940 369034 Cell-permeable ceramide analogs mimicked the *effect* on [MAPK] inhibition and PP-2A activation . Regulation MAPK13 TNF 9439626 482908 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic *effect* of requires protein tyrosine phosphorylation and [MAPK] activation . Regulation MAPK13 TNF 9559646 500221 Here , we have studied the *role* of several receptor associated proteins and caspases in p38 [MAPK] activation by TNF . Regulation MAPK13 TNF 9930718 588850 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Regulation MAPK13 TNF 9931102 588943 To identify which receptor is *involved* in TNF-alpha induced [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Regulation MAPK14 ADRB2 19047375 2023497 Hematopoietic protein tyrosine phosphatase mediates induced *regulation* of p38 [mitogen activated protein kinase] in B lymphocytes . Regulation MAPK14 ALOX5 21200133 2391708 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Regulation MAPK14 ANGPT1 24308939 2877807 The functional roles of DUSPs in induced *regulation* of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Regulation MAPK14 CD14 12595465 1061552 The LPS receptor complex utilized by the bladder epithelial cell lines included and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 [mitogen activated protein kinase] . Regulation MAPK14 CTGF 19038999 2023111 Interestingly , did not *affect* the BMP-2/CCN2 induced phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Regulation MAPK14 EDN2 12193071 980976 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Regulation MAPK14 EDN2 8632715 357249 *Effects* of on [mitogen activated protein kinase] activity and protein synthesis in isolated adult feline cardiac myocytes . Regulation MAPK14 EPHB2 10207619 606872 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein are regulated by MAPK/ERK kinases (MEKs) and MEKs , in turn , are *regulated* by [MAPK kinase kinases (MAPKKKs)] . Regulation MAPK14 EPHB2 12486127 1056322 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain had little *effect* on basal Erk [MAPK] activation . Regulation MAPK14 EPHB2 12486127 1056349 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [MAPK] *regulation* plays a significant role in axon guidance . Regulation MAPK14 EPHB2 15149321 1248346 PPAR gamma activity is *regulated* by extracellular signal regulated protein kinase ( ERK ) , [mitogen activated protein (MAP) kinase] , and PPAR gamma ligands have varying effects on activity of . Regulation MAPK14 EPHB2 15683363 1395438 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [MAPK] *regulation* . Regulation MAPK14 EPHB2 16098594 1507098 We , previously , showed that PKC *dependent* [MAPK] activation was inhibited by treating the resting B cell line 38B9 with an anti-MHC class II antibody . Regulation MAPK14 EPHB2 17056059 1649541 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Regulation MAPK14 EPHB2 19428358 2077047 The time-course analysis of PA accumulation and [mitogen activated protein kinase (MAPK)] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation MAPK14 FAS 21613257 2454290 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Regulation MAPK14 FHL1 23456229 2781834 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Regulation MAPK14 GPR115 11916960 946477 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK14 GPR115 15555614 1339441 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK14 GPR132 11916960 946466 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK14 GPR132 15555614 1339430 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK14 GPR87 11916960 946546 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK14 GPR87 15555614 1339510 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK14 ID1 23867624 2821340 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and [MAPK] signaling and gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation MAPK14 IL1B 10864897 705702 We therefore investigated the *effects* of TNF-alpha and on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK14 IL1B 10864897 705754 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK14 IL1B 10969830 728500 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Regulation MAPK14 IL1B 11040101 741905 While IL-1 beta phosphorylated c-Jun N-terminus protein kinase (JNK) rapidly and transiently , the *effect* of on p38 [mitogen activated protein kinase (MAPK)] was gradual and persistent . Regulation MAPK14 IL1B 14563491 1154874 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Regulation MAPK14 IL1B 17390080 1716178 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Regulation MAPK14 IL1B 19685010 2186169 The aim of this study was to compare the *effects* of TNF-alpha , and IFN-gamma on the activation of protein kinase B (PKB) , p70 ( S6k ) , [mitogen activated protein kinase (MAPK)] and p90 ( rsk ) , and on IGF-I stimulated glucose uptake and protein synthesis in mouse C2C12 myotubes . Regulation MAPK14 MAP2K6 10471331 641725 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Regulation MAPK14 MAP2K6 12009309 940921 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Regulation MAPK14 MAP2K6 12637559 1085626 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Regulation MAPK14 MAP2K6 12929129 1132091 The p75 ( NTR ) -induced [MAPK] activation is *dependent* but Raf independent . Regulation MAPK14 MAP2K6 14505338 1144739 The inhibitory *effect* of the inhibitor on [MAPK] phosphorylation was , therefore , suggested to counteract the cytoprotective effects of pro-vitamin C via a thorough interruption of the phosphorylated MAPK signaling pathway . Regulation MAPK14 MAP2K6 15064239 1231342 These results suggest that in HTSMCs , LTA stimulated p42/p44 [MAPK] phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , , and PI 3-kinase . Regulation MAPK14 MAP2K6 8550616 346790 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Regulation MAPK14 MAP2K6 9744865 532709 Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 [MAPK] and its *regulation* by the Ste7 . Regulation MAPK14 PECAM1 18029285 1866936 In contrast , expression of Delta15 in PECAM-1-/- bEND cells had minimal *effects* on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Regulation MAPK14 PGC 20955697 2407044 Finally , inhibition of PPAR? activation by a PPAR? antagonist GW9662 abolished the suppressive *effects* of on p38 [MAPK] phosphorylation and VSMC migration . Regulation MAPK14 PLAU 12759445 1091219 There was no *effect* of on LPS induced activation of p38 [mitogen activated protein kinase] in neutrophils . Regulation MAPK14 PLAU 15874933 1405719 Activation of the [mitogen activated protein kinases (MAPK)] , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Regulation MAPK14 SPHK1 20498849 2263726 In addition , our results also unraveled a novel *regulation* of [p38MAPK] by during M. smegmatis infection and generation of NO in macrophages . Regulation MAPK14 TLR7 22109714 2568328 The regulatory effect of complement on signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased [mitogen activated protein kinase] and nuclear factor ?B activation . Regulation MAPK14 TLR7 23979601 2850825 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Regulation MAPK14 TNF 10464169 640327 Therefore , both PI 3-K and p38 [MAPK] signaling pathways *control* production in T cells . Regulation MAPK14 TNF 10864897 705701 We therefore investigated the *effects* of and IL-1beta on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK14 TNF 10864897 705753 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK14 TNF 11833090 910324 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of in spleen , and p38 [MAPK] may be *involved* in its signal transduction mechanisms . Regulation MAPK14 TNF 12297009 991065 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Regulation MAPK14 TNF 12297293 991259 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Regulation MAPK14 TNF 12543078 1028760 Together , the p43 induced production was *controlled* by NFkB , p38 [MAPK] , and ERK that is dependent on the activities of PLC and PKC . Regulation MAPK14 TNF 14632659 1170636 In the present study , we analysed the *effects* of and 2,4-dinitrochlorobenzene ( DNCB ) on phenotypic maturation and p38 [mitogen activated protein kinase (MAPK)] activity , using a murine DC line . Regulation MAPK14 TNF 15545827 1337972 The results suggest altered *regulation* of Erk 1/2 and p38 [MAPK] signal translation pathways by endogenously produced , or some compound dependent on TNF may modulate , in part , the phosphorylation state of eIF4E in skeletal muscle during sepsis . Regulation MAPK14 TNF 15792609 1386779 *played* a role in induction of Akt and [MAPK] signals in ameloblastoma . Regulation MAPK14 TNF 16798728 1638548 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Regulation MAPK14 TNF 17031491 1641612 The aim of this study was to investigate the *effects* of stimulation on [MAPK] activation , and the pro- or anti-apoptotic role of these kinases in LNCaP and PC3 cells . Regulation MAPK14 TNF 17074860 1675492 p38 [mitogen activated protein kinase] *controls* NF-kappaB transcriptional activation and alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation MAPK14 TNF 17438131 1742727 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Regulation MAPK14 TNF 19429670 2106833 Then , we examined the *effect* of Ang II and/or on phosphorylation of extracellular signal regulated kinase ( ERK ) , [p38MAPK] , and IkappaB-alpha . Regulation MAPK14 TNF 19648110 2138432 Thus , MKP-1 attenuates *dependent* activation of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Regulation MAPK14 TNF 21949112 2512481 We find that Ga ( i/o ) -mediated activation of the [MAPK] is *independent* of the canonical MyD88 , interleukin-1 receptor associated kinase , and receptor associated factor 6 signaling cascade in LPS stimulated cells . Regulation MAPK14 TNF 22250084 2551231 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Regulation MAPK14 TNF 22988345 2674370 The EGF receptor and HER2 participate in *dependent* [MAPK] activation and IL-8 secretion in intestinal epithelial cells . Regulation MAPK14 TNF 23557259 2777873 The p38 MAPK activation and production were *controlled* by p38 [MAPK] and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation MAPK14 TNF 23861542 2817286 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Regulation MAPK14 TNF 24446489 2912952 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Regulation MAPK14 TNF 8665940 369035 Cell-permeable ceramide analogs mimicked the *effect* on [MAPK] inhibition and PP-2A activation . Regulation MAPK14 TNF 9439626 482909 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic *effect* of requires protein tyrosine phosphorylation and [MAPK] activation . Regulation MAPK14 TNF 9559646 500222 Here , we have studied the *role* of several receptor associated proteins and caspases in p38 [MAPK] activation by TNF . Regulation MAPK14 TNF 9930718 588851 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Regulation MAPK14 TNF 9931102 588944 To identify which receptor is *involved* in TNF-alpha induced [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Regulation MAPK15 ADRB2 19047375 2023491 Hematopoietic protein tyrosine phosphatase mediates induced *regulation* of p38 [mitogen activated protein kinase] in B lymphocytes . Regulation MAPK15 ALOX5 21200133 2391702 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Regulation MAPK15 ANGPT1 24308939 2877801 The functional roles of DUSPs in induced *regulation* of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Regulation MAPK15 CD14 12595465 1061546 The LPS receptor complex utilized by the bladder epithelial cell lines included and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 [mitogen activated protein kinase] . Regulation MAPK15 CTGF 19038999 2023099 Interestingly , did not *affect* the BMP-2/CCN2 induced phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Regulation MAPK15 EDN2 12193071 980955 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Regulation MAPK15 EDN2 8632715 357231 *Effects* of on [mitogen activated protein kinase] activity and protein synthesis in isolated adult feline cardiac myocytes . Regulation MAPK15 EPHB2 10207619 606853 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein are regulated by MAPK/ERK kinases (MEKs) and MEKs , in turn , are *regulated* by [MAPK kinase kinases (MAPKKKs)] . Regulation MAPK15 EPHB2 12486127 1056316 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain had little *effect* on basal Erk [MAPK] activation . Regulation MAPK15 EPHB2 12486127 1056330 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [MAPK] *regulation* plays a significant role in axon guidance . Regulation MAPK15 EPHB2 15149321 1248340 PPAR gamma activity is *regulated* by extracellular signal regulated protein kinase ( ERK ) , [mitogen activated protein (MAP) kinase] , and PPAR gamma ligands have varying effects on activity of . Regulation MAPK15 EPHB2 15683363 1395419 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [MAPK] *regulation* . Regulation MAPK15 EPHB2 16098594 1507086 We , previously , showed that PKC *dependent* [MAPK] activation was inhibited by treating the resting B cell line 38B9 with an anti-MHC class II antibody . Regulation MAPK15 EPHB2 17056059 1649535 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Regulation MAPK15 EPHB2 19428358 2077028 The time-course analysis of PA accumulation and [mitogen activated protein kinase (MAPK)] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation MAPK15 FAS 21613257 2454284 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Regulation MAPK15 FHL1 23456229 2781826 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Regulation MAPK15 GPR115 11916960 945919 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK15 GPR115 15555614 1338883 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK15 GPR132 11916960 945908 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK15 GPR132 15555614 1338872 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK15 GPR87 11916960 945988 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK15 GPR87 15555614 1338952 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK15 ID1 23867624 2821321 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and [MAPK] signaling and gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation MAPK15 IL1B 10864897 705690 We therefore investigated the *effects* of TNF-alpha and on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK15 IL1B 10864897 705742 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK15 IL1B 10969830 728494 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Regulation MAPK15 IL1B 11040101 741899 While IL-1 beta phosphorylated c-Jun N-terminus protein kinase (JNK) rapidly and transiently , the *effect* of on p38 [mitogen activated protein kinase (MAPK)] was gradual and persistent . Regulation MAPK15 IL1B 14563491 1154868 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Regulation MAPK15 IL1B 17390080 1716172 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Regulation MAPK15 IL1B 19685010 2186153 The aim of this study was to compare the *effects* of TNF-alpha , and IFN-gamma on the activation of protein kinase B (PKB) , p70 ( S6k ) , [mitogen activated protein kinase (MAPK)] and p90 ( rsk ) , and on IGF-I stimulated glucose uptake and protein synthesis in mouse C2C12 myotubes . Regulation MAPK15 MAP2K6 10471331 641683 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Regulation MAPK15 MAP2K6 12009309 940879 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Regulation MAPK15 MAP2K6 12637559 1085566 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Regulation MAPK15 MAP2K6 12929129 1132049 The p75 ( NTR ) -induced [MAPK] activation is *dependent* but Raf independent . Regulation MAPK15 MAP2K6 14505338 1144697 The inhibitory *effect* of the inhibitor on [MAPK] phosphorylation was , therefore , suggested to counteract the cytoprotective effects of pro-vitamin C via a thorough interruption of the phosphorylated MAPK signaling pathway . Regulation MAPK15 MAP2K6 15064239 1231168 These results suggest that in HTSMCs , LTA stimulated p42/p44 [MAPK] phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , , and PI 3-kinase . Regulation MAPK15 MAP2K6 8550616 346742 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Regulation MAPK15 MAP2K6 9744865 532667 Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 [MAPK] and its *regulation* by the Ste7 . Regulation MAPK15 PECAM1 18029285 1866930 In contrast , expression of Delta15 in PECAM-1-/- bEND cells had minimal *effects* on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Regulation MAPK15 PGC 20955697 2407037 Finally , inhibition of PPAR? activation by a PPAR? antagonist GW9662 abolished the suppressive *effects* of on p38 [MAPK] phosphorylation and VSMC migration . Regulation MAPK15 PLAU 12759445 1091213 There was no *effect* of on LPS induced activation of p38 [mitogen activated protein kinase] in neutrophils . Regulation MAPK15 PLAU 15874933 1405706 Activation of the [mitogen activated protein kinases (MAPK)] , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Regulation MAPK15 SPHK1 20498849 2263719 In addition , our results also unraveled a novel *regulation* of [p38MAPK] by during M. smegmatis infection and generation of NO in macrophages . Regulation MAPK15 TLR7 22109714 2568268 The regulatory effect of complement on signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased [mitogen activated protein kinase] and nuclear factor ?B activation . Regulation MAPK15 TLR7 23979601 2850735 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Regulation MAPK15 TNF 10464169 640321 Therefore , both PI 3-K and p38 [MAPK] signaling pathways *control* production in T cells . Regulation MAPK15 TNF 10864897 705689 We therefore investigated the *effects* of and IL-1beta on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK15 TNF 10864897 705741 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK15 TNF 11833090 910318 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of in spleen , and p38 [MAPK] may be *involved* in its signal transduction mechanisms . Regulation MAPK15 TNF 12297009 991059 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Regulation MAPK15 TNF 12297293 991253 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Regulation MAPK15 TNF 12543078 1028753 Together , the p43 induced production was *controlled* by NFkB , p38 [MAPK] , and ERK that is dependent on the activities of PLC and PKC . Regulation MAPK15 TNF 14632659 1170629 In the present study , we analysed the *effects* of and 2,4-dinitrochlorobenzene ( DNCB ) on phenotypic maturation and p38 [mitogen activated protein kinase (MAPK)] activity , using a murine DC line . Regulation MAPK15 TNF 15545827 1337966 The results suggest altered *regulation* of Erk 1/2 and p38 [MAPK] signal translation pathways by endogenously produced , or some compound dependent on TNF may modulate , in part , the phosphorylation state of eIF4E in skeletal muscle during sepsis . Regulation MAPK15 TNF 15792609 1386770 *played* a role in induction of Akt and [MAPK] signals in ameloblastoma . Regulation MAPK15 TNF 16798728 1638542 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Regulation MAPK15 TNF 17031491 1641606 The aim of this study was to investigate the *effects* of stimulation on [MAPK] activation , and the pro- or anti-apoptotic role of these kinases in LNCaP and PC3 cells . Regulation MAPK15 TNF 17074860 1675474 p38 [mitogen activated protein kinase] *controls* NF-kappaB transcriptional activation and alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation MAPK15 TNF 17438131 1742720 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Regulation MAPK15 TNF 19429670 2106819 Then , we examined the *effect* of Ang II and/or on phosphorylation of extracellular signal regulated kinase ( ERK ) , [p38MAPK] , and IkappaB-alpha . Regulation MAPK15 TNF 19648110 2138425 Thus , MKP-1 attenuates *dependent* activation of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Regulation MAPK15 TNF 21949112 2512445 We find that Ga ( i/o ) -mediated activation of the [MAPK] is *independent* of the canonical MyD88 , interleukin-1 receptor associated kinase , and receptor associated factor 6 signaling cascade in LPS stimulated cells . Regulation MAPK15 TNF 22250084 2551219 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Regulation MAPK15 TNF 22988345 2674363 The EGF receptor and HER2 participate in *dependent* [MAPK] activation and IL-8 secretion in intestinal epithelial cells . Regulation MAPK15 TNF 23557259 2777841 The p38 MAPK activation and production were *controlled* by p38 [MAPK] and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation MAPK15 TNF 23861542 2817277 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Regulation MAPK15 TNF 24446489 2912946 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Regulation MAPK15 TNF 8665940 369029 Cell-permeable ceramide analogs mimicked the *effect* on [MAPK] inhibition and PP-2A activation . Regulation MAPK15 TNF 9439626 482903 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic *effect* of requires protein tyrosine phosphorylation and [MAPK] activation . Regulation MAPK15 TNF 9559646 500216 Here , we have studied the *role* of several receptor associated proteins and caspases in p38 [MAPK] activation by TNF . Regulation MAPK15 TNF 9930718 588845 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Regulation MAPK15 TNF 9931102 588938 To identify which receptor is *involved* in TNF-alpha induced [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Regulation MAPK3 ADRB2 12582207 1058663 Beta-arrestin depletion in HEK293 cells leads to enhanced cAMP generation in *response* to stimulation , markedly reduced beta(2)-adrenergic receptor and angiotensin II receptor internalization and impaired activation of the MAP kinases [ERK 1] and 2 by angiotensin II . Regulation MAPK3 ADRB2 19047375 2023498 Hematopoietic protein tyrosine phosphatase mediates induced *regulation* of p38 [mitogen activated protein kinase] in B lymphocytes . Regulation MAPK3 ADRB2 21412239 2438320 In contrast , coexpression of the or the pharmacologically non activated Ang II type 2 receptor ( AT(2) ) pretreated with the AT(2)-specific antagonist , PD123319 , did not *affect* [ERK1/2] phosphorylation through AT(1) . Regulation MAPK3 ALOX5 21200133 2391709 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Regulation MAPK3 ANGPT1 24308939 2877808 The functional roles of DUSPs in induced *regulation* of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Regulation MAPK3 CD14 12595465 1061553 The LPS receptor complex utilized by the bladder epithelial cell lines included and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 [mitogen activated protein kinase] . Regulation MAPK3 CTGF 19038999 2023113 Interestingly , did not *affect* the BMP-2/CCN2 induced phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Regulation MAPK3 EDN2 12193071 980979 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Regulation MAPK3 EDN2 8632715 357252 *Effects* of on [mitogen activated protein kinase] activity and protein synthesis in isolated adult feline cardiac myocytes . Regulation MAPK3 EFNB1 21795402 2476626 EphrinA1-Fc suppressed IGF-I induced activation of Ras and ERK1/2 , but not that of AKT , in C2C12 myoblasts , whereas *affected* neither [ERK1/2] nor AKT activated by IGF-I . Regulation MAPK3 EPHB2 10207619 606873 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein are regulated by MAPK/ERK kinases (MEKs) and MEKs , in turn , are *regulated* by [MAPK kinase kinases (MAPKKKs)] . Regulation MAPK3 EPHB2 12062026 952957 Our results reveal an unexpected complexity of dependent signaling in the brain and a critical regulatory *role* for [ERK1] in the long-term adaptive changes underlying striatum dependent behavioral plasticity and drug addiction . Regulation MAPK3 EPHB2 12486127 1056323 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain had little *effect* on basal Erk [MAPK] activation . Regulation MAPK3 EPHB2 12486127 1056350 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [MAPK] *regulation* plays a significant role in axon guidance . Regulation MAPK3 EPHB2 15149321 1248347 PPAR gamma activity is *regulated* by extracellular signal regulated protein kinase ( ERK ) , [mitogen activated protein (MAP) kinase] , and PPAR gamma ligands have varying effects on activity of . Regulation MAPK3 EPHB2 15683363 1395439 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [MAPK] *regulation* . Regulation MAPK3 EPHB2 16098594 1507100 We , previously , showed that PKC *dependent* [MAPK] activation was inhibited by treating the resting B cell line 38B9 with an anti-MHC class II antibody . Regulation MAPK3 EPHB2 17056059 1649542 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Regulation MAPK3 EPHB2 19428358 2077048 The time-course analysis of PA accumulation and [mitogen activated protein kinase (MAPK)] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation MAPK3 EPHB2 21503959 2463733 ATP induced the phosphorylation of [ERK1/2] , but the inhibitors , U0126 and PD9809 , did not *regulate* the inhibition of cell proliferation induced by ATP . Regulation MAPK3 F2R 20215560 2259582 Both receptors stimulated extracellular signal regulated kinase ( ERK) 1/2 phosphorylation , but only PAR1 inhibited adenylyl cyclase activity , and pertussis toxin blocked *effects* on both adenylyl cyclase and [ERK1/2] signaling . Regulation MAPK3 F2R 20215560 2259591 *effects* on [ERK1/2] phosphorylation and cell migration were blocked both by pertussis toxin and by the mitogen activated protein kinase kinase/ERK inhibitor [ 1,4-diamino-2,3-dicyano-1,4-bis ( methylthio ) butadiene ( U0126 ) ] , whereas PAR2 effects were only blocked by U0126 . Regulation MAPK3 FAS 21613257 2454291 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Regulation MAPK3 FHL1 23456229 2781835 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Regulation MAPK3 GPR115 11916960 946570 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK3 GPR115 15555614 1339534 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK3 GPR132 11916960 946559 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK3 GPR132 15555614 1339523 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK3 GPR87 11916960 946639 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK3 GPR87 15555614 1339603 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK3 HBEGF 21413023 2404921 synthesis and release induced by cholesterol depletion of human epidermal keratinocytes is controlled by extracellular ATP and *involves* both p38 and [ERK1/2] signaling pathways . Regulation MAPK3 ID1 23867624 2821341 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and [MAPK] signaling and gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation MAPK3 IL1B 10864897 705704 We therefore investigated the *effects* of TNF-alpha and on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK3 IL1B 10864897 705756 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK3 IL1B 10969830 728501 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Regulation MAPK3 IL1B 11040101 741906 While IL-1 beta phosphorylated c-Jun N-terminus protein kinase (JNK) rapidly and transiently , the *effect* of on p38 [mitogen activated protein kinase (MAPK)] was gradual and persistent . Regulation MAPK3 IL1B 14563491 1154875 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Regulation MAPK3 IL1B 17390080 1716179 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Regulation MAPK3 IL1B 19685010 2186171 The aim of this study was to compare the *effects* of TNF-alpha , and IFN-gamma on the activation of protein kinase B (PKB) , p70 ( S6k ) , [mitogen activated protein kinase (MAPK)] and p90 ( rsk ) , and on IGF-I stimulated glucose uptake and protein synthesis in mouse C2C12 myotubes . Regulation MAPK3 MAP2K6 10471331 641732 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Regulation MAPK3 MAP2K6 11168638 783209 Preincubation of human neutrophils with GF109203X ( an inhibitor of PKC ) , PD98059 ( an inhibitor of , the upstream *regulator* of [ERK1/ERK2] ) or with forskolin or dibutyryl cAMP , failed to suppress proteoglycan degradation of opsonized bovine cartilage . Regulation MAPK3 MAP2K6 12009309 940928 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Regulation MAPK3 MAP2K6 12637559 1085636 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Regulation MAPK3 MAP2K6 12688676 1078843 Inhibition of 1 ( MEK1 ) , an upstream *regulator* of [ERK1/2] , with PD98059 resulted in a dose dependent reduction of invasiveness with different IC50 values in the three Dunning cell lines . Regulation MAPK3 MAP2K6 12807428 1101830 Blockade of PI3K in combination with insulin , however , still resulted in an unaltered *dependent* phosphorylation of [ERK1/2] . Regulation MAPK3 MAP2K6 12929129 1132098 The p75 ( NTR ) -induced [MAPK] activation is *dependent* but Raf independent . Regulation MAPK3 MAP2K6 14505338 1144746 The inhibitory *effect* of the inhibitor on [MAPK] phosphorylation was , therefore , suggested to counteract the cytoprotective effects of pro-vitamin C via a thorough interruption of the phosphorylated MAPK signaling pathway . Regulation MAPK3 MAP2K6 15064239 1231351 These results suggest that in HTSMCs , LTA stimulated p42/p44 [MAPK] phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , , and PI 3-kinase . Regulation MAPK3 MAP2K6 15231676 1269278 Thus , activation of FGF-1- and HRGbeta1-specific signaling causes *dependent* prolonged activation of [ERK1/2] , which is incompletely susceptible to known MEK inhibitors . Regulation MAPK3 MAP2K6 15647286 1381488 In vitro analyses offer mechanistic support for the role of mechanical stimuli in promoting a *dependent* activation of [ERK1/2] . Regulation MAPK3 MAP2K6 15757891 1417033 We also report a prolonged *dependent* activation of [ERK1/2] and increased c-FOS expression induced by TRAIL in this system . Regulation MAPK3 MAP2K6 19018267 2001455 Cl-1040 is a compound that selectively inhibits , an upstream *regulator* of [ERK1/2] , and thus prevents ERK1/2 activation . Regulation MAPK3 MAP2K6 8550616 346798 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Regulation MAPK3 MAP2K6 9744865 532716 Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 [MAPK] and its *regulation* by the Ste7 . Regulation MAPK3 MAP2K6 9804770 544443 Furthermore , NE stimulated the expression and secretion of basic fibroblast growth factor (bFGF) , which further promoted the cell survival via *dependent* activation of [Erk1/2] . Regulation MAPK3 MMP28 16336626 1503810 In contrast , phosphorylation of the EGF-R , Shc and [ERK1/2] by EGF and HB-EGF was *independent* of PKC and activity . Regulation MAPK3 MMP7 16336626 1503825 In contrast , phosphorylation of the EGF-R , Shc and [ERK1/2] by EGF and HB-EGF was *independent* of PKC and activity . Regulation MAPK3 PECAM1 18029285 1866937 In contrast , expression of Delta15 in PECAM-1-/- bEND cells had minimal *effects* on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Regulation MAPK3 PGC 20955697 2407045 Finally , inhibition of PPAR? activation by a PPAR? antagonist GW9662 abolished the suppressive *effects* of on p38 [MAPK] phosphorylation and VSMC migration . Regulation MAPK3 PLAT 19171142 2049012 Down-regulation of Gal-1 by small interference RNA was used to analyze the *involvement* of interaction in [extracellular signal regulated kinase 1/2] activation , cell proliferation , and invasion in pancreatic and fibroblastic cells . Regulation MAPK3 PLAT 19171142 2049014 Down-regulation of Gal-1 abolished the *effects* of on [extracellular signal regulated kinase 1/2] activation , cell proliferation , and invasion , both in pancreatic and in tumor derived fibroblasts . Regulation MAPK3 PLAT 24129569 2875080 Rapid [ERK1/2] activation in *response* to and activated a2-macroglobulin ( a2M* ) required the NMDA receptor and Trk receptors , which assemble with LRP1 into a single pathway . Regulation MAPK3 PLAT 24129569 2875082 Lactoferrin functioned as an LRP1 signaling antagonist , inhibiting Trk receptor phosphorylation and [ERK1/2] activation in *response* to . Regulation MAPK3 PLAU 12759445 1091220 There was no *effect* of on LPS induced activation of p38 [mitogen activated protein kinase] in neutrophils . Regulation MAPK3 PLAU 15874933 1405720 Activation of the mitogen activated protein kinases (MAPK) , [extracellular signal regulated kinase 1/2] ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Regulation MAPK3 SPHK1 15993704 1429721 Inhibition of also did not *affect* EGF stimulated phosphorylation of PI-3 kinase , Akt , [ERK1/2] or p38 but inhibition of PI-3 kinase with a specific inhibitor LY294002 partly ( 40 % ) inhibited the EGF stimulated increase in SPHK-1 activity . Regulation MAPK3 SPHK1 16278291 1502532 Additional data revealed a specific role of dhS1P , and not S1P , as a mediator of *dependent* activation of [ERK1/2] and up-regulation of MMP1 . Regulation MAPK3 SPHK1 20498849 2263727 In addition , our results also unraveled a novel *regulation* of [p38MAPK] by during M. smegmatis infection and generation of NO in macrophages . Regulation MAPK3 TCN1 18959821 1982903 ( C8orf4 ) is *involved* in [ERK1/2] pathway regulated G(1)- to S-phase transition . Regulation MAPK3 TLR7 22109714 2568338 The regulatory effect of complement on signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased [mitogen activated protein kinase] and nuclear factor ?B activation . Regulation MAPK3 TLR7 23979601 2850835 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Regulation MAPK3 TNF 10464169 640328 Therefore , both PI 3-K and p38 [MAPK] signaling pathways *control* production in T cells . Regulation MAPK3 TNF 10864897 705703 We therefore investigated the *effects* of and IL-1beta on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK3 TNF 10864897 705755 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK3 TNF 11689211 876137 The aim of this study was to investigate the expression of the transcription factors Ets-1 , Egr-1 and c-fos in different types of vascular lesions , their *regulation* by and the role of [ERK 1/2] in these signaling events . Regulation MAPK3 TNF 11833090 910325 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of in spleen , and p38 [MAPK] may be *involved* in its signal transduction mechanisms . Regulation MAPK3 TNF 12297009 991066 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Regulation MAPK3 TNF 12297293 991260 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Regulation MAPK3 TNF 12483539 1024803 In addition , PP1 substantially inhibited the IL-2beta- and *dependent* activation of [Erk 1/2] and Akt . Regulation MAPK3 TNF 12543078 1028761 Together , the p43 induced production was *controlled* by NFkB , p38 [MAPK] , and ERK that is dependent on the activities of PLC and PKC . Regulation MAPK3 TNF 14632659 1170637 In the present study , we analysed the *effects* of and 2,4-dinitrochlorobenzene ( DNCB ) on phenotypic maturation and p38 [mitogen activated protein kinase (MAPK)] activity , using a murine DC line . Regulation MAPK3 TNF 15087472 1258141 Stimulatory *effects* of on neuropeptide gene expression and release appeared to be mediated through the type 2 TNF-alpha receptor , and required activation of [ERK 1/2] and p38 , but not Janus kinase , MAPKs . Regulation MAPK3 TNF 15545827 1337973 The results suggest altered *regulation* of Erk 1/2 and p38 [MAPK] signal translation pathways by endogenously produced , or some compound dependent on TNF may modulate , in part , the phosphorylation state of eIF4E in skeletal muscle during sepsis . Regulation MAPK3 TNF 15792609 1386780 *played* a role in induction of Akt and [MAPK] signals in ameloblastoma . Regulation MAPK3 TNF 16081599 1460449 These results indicate that gp120 elicited production by macrophages involves chemokine receptor mediated PI-3K and MAPK activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and [ERK-1/2] independently *regulate* TNF-alpha production . Regulation MAPK3 TNF 16798728 1638549 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Regulation MAPK3 TNF 16806337 1585958 E2 significantly attenuated the *effects* of on [ERK1/2] activity , apoptosis , and E-selectin expression in the cells . Regulation MAPK3 TNF 17031491 1641613 The aim of this study was to investigate the *effects* of stimulation on [MAPK] activation , and the pro- or anti-apoptotic role of these kinases in LNCaP and PC3 cells . Regulation MAPK3 TNF 17074860 1675495 p38 [mitogen activated protein kinase] *controls* NF-kappaB transcriptional activation and alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation MAPK3 TNF 17227768 1703826 We tested whether mitogenic activated protein kinase kinase kinase kinase isoform 4 ( MAP4K4 ) causes the induced negative *regulation* of [extracellular signal regulated kinase-1/2] ( ERK-1/2 ) , c-Jun NH2-terminal kinase (JNK) , and the insulin receptor substrate-1 (IRS-1) on the insulin signaling pathway governing glucose metabolism . Regulation MAPK3 TNF 17438131 1742728 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Regulation MAPK3 TNF 19429670 2106835 Then , we examined the *effect* of Ang II and/or on phosphorylation of extracellular signal regulated kinase ( ERK ) , [p38MAPK] , and IkappaB-alpha . Regulation MAPK3 TNF 19648110 2138433 Thus , MKP-1 attenuates *dependent* activation of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Regulation MAPK3 TNF 19808894 2187059 IkappaB kinase-(IKK)-beta inhibition prevented mitogen activated protein (MAP) kinase kinase ( MEK ) [/ERK1/2] activation in *response* to interleukin (IL)-1beta and but not insulin in 3T3-L1 and human adipocytes , suggesting that IKKbeta regulated a MAP kinase kinase kinase ( MAP3K ) involved in ERK1/2 activation induced by inflammatory cytokines . Regulation MAPK3 TNF 20537761 2289694 Finally , PPARgamma-overexpression results in a reduction of [ERK1/2] phosphorylation and inflammatory secretions in *response* to and IFNgamma even in the absence of RGZ , suggesting a restraining effect controlled by endogenous ligands . Regulation MAPK3 TNF 21949112 2512487 We find that Ga ( i/o ) -mediated activation of the [MAPK] is *independent* of the canonical MyD88 , interleukin-1 receptor associated kinase , and receptor associated factor 6 signaling cascade in LPS stimulated cells . Regulation MAPK3 TNF 22250084 2551233 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Regulation MAPK3 TNF 22800929 2645766 In vitro , we examined the effects of IF inhibition on production and the *regulation* of [ERK1/2] and p38 phosphorylation activity in LPS induced mouse peritoneal macrophages . Regulation MAPK3 TNF 22988345 2674371 The EGF receptor and HER2 participate in *dependent* [MAPK] activation and IL-8 secretion in intestinal epithelial cells . Regulation MAPK3 TNF 23159491 2729682 Finally , we demonstrate that the transmembrane forms of wild-type and palmitoylation-defective interact differently with TNFR1 and *regulate* NF?B activity , [Erk1/2] phosphorylation and interleukin-6 synthesis differently , strongly suggesting that palmitoylation of TNF is involved in the regulation of TNFR1 signalling . Regulation MAPK3 TNF 23557259 2777876 The p38 MAPK activation and production were *controlled* by p38 [MAPK] and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation MAPK3 TNF 23861542 2817287 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Regulation MAPK3 TNF 24446489 2912953 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Regulation MAPK3 TNF 8665940 369036 Cell-permeable ceramide analogs mimicked the *effect* on [MAPK] inhibition and PP-2A activation . Regulation MAPK3 TNF 9439626 482910 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic *effect* of requires protein tyrosine phosphorylation and [MAPK] activation . Regulation MAPK3 TNF 9559646 500223 Here , we have studied the *role* of several receptor associated proteins and caspases in p38 [MAPK] activation by TNF . Regulation MAPK3 TNF 9930718 588852 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Regulation MAPK3 TNF 9931102 588945 To identify which receptor is *involved* in TNF-alpha induced [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Regulation MAPK4 ADRB2 19047375 2023499 Hematopoietic protein tyrosine phosphatase mediates induced *regulation* of p38 [mitogen activated protein kinase] in B lymphocytes . Regulation MAPK4 ALOX5 21200133 2391710 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Regulation MAPK4 ANGPT1 24308939 2877809 The functional roles of DUSPs in induced *regulation* of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Regulation MAPK4 CD14 12595465 1061554 The LPS receptor complex utilized by the bladder epithelial cell lines included and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 [mitogen activated protein kinase] . Regulation MAPK4 CTGF 19038999 2023115 Interestingly , did not *affect* the BMP-2/CCN2 induced phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Regulation MAPK4 EDN2 12193071 980982 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Regulation MAPK4 EDN2 8632715 357255 *Effects* of on [mitogen activated protein kinase] activity and protein synthesis in isolated adult feline cardiac myocytes . Regulation MAPK4 EPHB2 10207619 606874 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein are regulated by MAPK/ERK kinases (MEKs) and MEKs , in turn , are *regulated* by [MAPK kinase kinases (MAPKKKs)] . Regulation MAPK4 EPHB2 12486127 1056324 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain had little *effect* on basal Erk [MAPK] activation . Regulation MAPK4 EPHB2 12486127 1056351 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [MAPK] *regulation* plays a significant role in axon guidance . Regulation MAPK4 EPHB2 15149321 1248348 PPAR gamma activity is *regulated* by extracellular signal regulated protein kinase ( ERK ) , [mitogen activated protein (MAP) kinase] , and PPAR gamma ligands have varying effects on activity of . Regulation MAPK4 EPHB2 15683363 1395440 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [MAPK] *regulation* . Regulation MAPK4 EPHB2 16098594 1507102 We , previously , showed that PKC *dependent* [MAPK] activation was inhibited by treating the resting B cell line 38B9 with an anti-MHC class II antibody . Regulation MAPK4 EPHB2 17056059 1649543 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Regulation MAPK4 EPHB2 19428358 2077049 The time-course analysis of PA accumulation and [mitogen activated protein kinase (MAPK)] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation MAPK4 FAS 21613257 2454292 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Regulation MAPK4 FHL1 23456229 2781836 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Regulation MAPK4 GPR115 11916960 946663 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK4 GPR115 15555614 1339627 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK4 GPR132 11916960 946652 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK4 GPR132 15555614 1339616 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK4 GPR87 11916960 946732 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK4 GPR87 15555614 1339696 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK4 ID1 23867624 2821342 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and [MAPK] signaling and gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation MAPK4 IL1B 10864897 705706 We therefore investigated the *effects* of TNF-alpha and on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK4 IL1B 10864897 705758 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK4 IL1B 10969830 728502 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Regulation MAPK4 IL1B 11040101 741907 While IL-1 beta phosphorylated c-Jun N-terminus protein kinase (JNK) rapidly and transiently , the *effect* of on p38 [mitogen activated protein kinase (MAPK)] was gradual and persistent . Regulation MAPK4 IL1B 14563491 1154876 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Regulation MAPK4 IL1B 17390080 1716180 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Regulation MAPK4 IL1B 19685010 2186173 The aim of this study was to compare the *effects* of TNF-alpha , and IFN-gamma on the activation of protein kinase B (PKB) , p70 ( S6k ) , [mitogen activated protein kinase (MAPK)] and p90 ( rsk ) , and on IGF-I stimulated glucose uptake and protein synthesis in mouse C2C12 myotubes . Regulation MAPK4 MAP2K6 10471331 641739 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Regulation MAPK4 MAP2K6 12009309 940935 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Regulation MAPK4 MAP2K6 12637559 1085646 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Regulation MAPK4 MAP2K6 12929129 1132105 The p75 ( NTR ) -induced [MAPK] activation is *dependent* but Raf independent . Regulation MAPK4 MAP2K6 14505338 1144753 The inhibitory *effect* of the inhibitor on [MAPK] phosphorylation was , therefore , suggested to counteract the cytoprotective effects of pro-vitamin C via a thorough interruption of the phosphorylated MAPK signaling pathway . Regulation MAPK4 MAP2K6 15064239 1231360 These results suggest that in HTSMCs , LTA stimulated p42/p44 [MAPK] phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , , and PI 3-kinase . Regulation MAPK4 MAP2K6 8550616 346806 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Regulation MAPK4 MAP2K6 9744865 532723 Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 [MAPK] and its *regulation* by the Ste7 . Regulation MAPK4 PECAM1 18029285 1866938 In contrast , expression of Delta15 in PECAM-1-/- bEND cells had minimal *effects* on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Regulation MAPK4 PGC 20955697 2407046 Finally , inhibition of PPAR? activation by a PPAR? antagonist GW9662 abolished the suppressive *effects* of on p38 [MAPK] phosphorylation and VSMC migration . Regulation MAPK4 PLAU 12759445 1091221 There was no *effect* of on LPS induced activation of p38 [mitogen activated protein kinase] in neutrophils . Regulation MAPK4 PLAU 15874933 1405721 Activation of the [mitogen activated protein kinases (MAPK)] , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Regulation MAPK4 SPHK1 20498849 2263728 In addition , our results also unraveled a novel *regulation* of [p38MAPK] by during M. smegmatis infection and generation of NO in macrophages . Regulation MAPK4 TLR7 22109714 2568348 The regulatory effect of complement on signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased [mitogen activated protein kinase] and nuclear factor ?B activation . Regulation MAPK4 TLR7 23979601 2850845 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Regulation MAPK4 TNF 10464169 640329 Therefore , both PI 3-K and p38 [MAPK] signaling pathways *control* production in T cells . Regulation MAPK4 TNF 10864897 705705 We therefore investigated the *effects* of and IL-1beta on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK4 TNF 10864897 705757 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK4 TNF 11833090 910326 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of in spleen , and p38 [MAPK] may be *involved* in its signal transduction mechanisms . Regulation MAPK4 TNF 12297009 991067 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Regulation MAPK4 TNF 12297293 991261 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Regulation MAPK4 TNF 12543078 1028762 Together , the p43 induced production was *controlled* by NFkB , p38 [MAPK] , and ERK that is dependent on the activities of PLC and PKC . Regulation MAPK4 TNF 14632659 1170638 In the present study , we analysed the *effects* of and 2,4-dinitrochlorobenzene ( DNCB ) on phenotypic maturation and p38 [mitogen activated protein kinase (MAPK)] activity , using a murine DC line . Regulation MAPK4 TNF 15545827 1337974 The results suggest altered *regulation* of Erk 1/2 and p38 [MAPK] signal translation pathways by endogenously produced , or some compound dependent on TNF may modulate , in part , the phosphorylation state of eIF4E in skeletal muscle during sepsis . Regulation MAPK4 TNF 15792609 1386781 *played* a role in induction of Akt and [MAPK] signals in ameloblastoma . Regulation MAPK4 TNF 16798728 1638550 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Regulation MAPK4 TNF 17031491 1641614 The aim of this study was to investigate the *effects* of stimulation on [MAPK] activation , and the pro- or anti-apoptotic role of these kinases in LNCaP and PC3 cells . Regulation MAPK4 TNF 17074860 1675498 p38 [mitogen activated protein kinase] *controls* NF-kappaB transcriptional activation and alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation MAPK4 TNF 17438131 1742729 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Regulation MAPK4 TNF 19429670 2106837 Then , we examined the *effect* of Ang II and/or on phosphorylation of extracellular signal regulated kinase ( ERK ) , [p38MAPK] , and IkappaB-alpha . Regulation MAPK4 TNF 19648110 2138434 Thus , MKP-1 attenuates *dependent* activation of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Regulation MAPK4 TNF 21949112 2512493 We find that Ga ( i/o ) -mediated activation of the [MAPK] is *independent* of the canonical MyD88 , interleukin-1 receptor associated kinase , and receptor associated factor 6 signaling cascade in LPS stimulated cells . Regulation MAPK4 TNF 22250084 2551235 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Regulation MAPK4 TNF 22988345 2674372 The EGF receptor and HER2 participate in *dependent* [MAPK] activation and IL-8 secretion in intestinal epithelial cells . Regulation MAPK4 TNF 23557259 2777879 The p38 MAPK activation and production were *controlled* by p38 [MAPK] and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation MAPK4 TNF 23861542 2817288 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Regulation MAPK4 TNF 24446489 2912954 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Regulation MAPK4 TNF 8665940 369037 Cell-permeable ceramide analogs mimicked the *effect* on [MAPK] inhibition and PP-2A activation . Regulation MAPK4 TNF 9439626 482911 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic *effect* of requires protein tyrosine phosphorylation and [MAPK] activation . Regulation MAPK4 TNF 9559646 500224 Here , we have studied the *role* of several receptor associated proteins and caspases in p38 [MAPK] activation by TNF . Regulation MAPK4 TNF 9930718 588853 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Regulation MAPK4 TNF 9931102 588946 To identify which receptor is *involved* in TNF-alpha induced [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Regulation MAPK6 ADRB2 19047375 2023500 Hematopoietic protein tyrosine phosphatase mediates induced *regulation* of p38 [mitogen activated protein kinase] in B lymphocytes . Regulation MAPK6 ALOX5 21200133 2391711 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Regulation MAPK6 ANGPT1 24308939 2877810 The functional roles of DUSPs in induced *regulation* of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Regulation MAPK6 CD14 12595465 1061555 The LPS receptor complex utilized by the bladder epithelial cell lines included and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 [mitogen activated protein kinase] . Regulation MAPK6 CTGF 19038999 2023117 Interestingly , did not *affect* the BMP-2/CCN2 induced phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Regulation MAPK6 EDN2 12193071 980985 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Regulation MAPK6 EDN2 8632715 357258 *Effects* of on [mitogen activated protein kinase] activity and protein synthesis in isolated adult feline cardiac myocytes . Regulation MAPK6 EPHB2 10207619 606875 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein are regulated by MAPK/ERK kinases (MEKs) and MEKs , in turn , are *regulated* by [MAPK kinase kinases (MAPKKKs)] . Regulation MAPK6 EPHB2 12486127 1056325 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain had little *effect* on basal Erk [MAPK] activation . Regulation MAPK6 EPHB2 12486127 1056352 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [MAPK] *regulation* plays a significant role in axon guidance . Regulation MAPK6 EPHB2 15149321 1248349 PPAR gamma activity is *regulated* by extracellular signal regulated protein kinase ( ERK ) , [mitogen activated protein (MAP) kinase] , and PPAR gamma ligands have varying effects on activity of . Regulation MAPK6 EPHB2 15683363 1395441 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [MAPK] *regulation* . Regulation MAPK6 EPHB2 16098594 1507104 We , previously , showed that PKC *dependent* [MAPK] activation was inhibited by treating the resting B cell line 38B9 with an anti-MHC class II antibody . Regulation MAPK6 EPHB2 17056059 1649544 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Regulation MAPK6 EPHB2 19428358 2077050 The time-course analysis of PA accumulation and [mitogen activated protein kinase (MAPK)] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation MAPK6 FAS 21613257 2454293 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Regulation MAPK6 FHL1 23456229 2781837 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Regulation MAPK6 GPR115 11916960 946756 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK6 GPR115 15555614 1339720 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK6 GPR132 11916960 946745 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK6 GPR132 15555614 1339709 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK6 GPR87 11916960 946825 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK6 GPR87 15555614 1339789 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK6 ID1 23867624 2821343 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and [MAPK] signaling and gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation MAPK6 IL1B 10864897 705708 We therefore investigated the *effects* of TNF-alpha and on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK6 IL1B 10864897 705760 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK6 IL1B 10969830 728503 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Regulation MAPK6 IL1B 11040101 741908 While IL-1 beta phosphorylated c-Jun N-terminus protein kinase (JNK) rapidly and transiently , the *effect* of on p38 [mitogen activated protein kinase (MAPK)] was gradual and persistent . Regulation MAPK6 IL1B 14563491 1154877 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Regulation MAPK6 IL1B 17390080 1716181 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Regulation MAPK6 IL1B 19685010 2186175 The aim of this study was to compare the *effects* of TNF-alpha , and IFN-gamma on the activation of protein kinase B (PKB) , p70 ( S6k ) , [mitogen activated protein kinase (MAPK)] and p90 ( rsk ) , and on IGF-I stimulated glucose uptake and protein synthesis in mouse C2C12 myotubes . Regulation MAPK6 MAP2K6 10471331 641746 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Regulation MAPK6 MAP2K6 12009309 940942 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Regulation MAPK6 MAP2K6 12637559 1085656 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Regulation MAPK6 MAP2K6 12929129 1132112 The p75 ( NTR ) -induced [MAPK] activation is *dependent* but Raf independent . Regulation MAPK6 MAP2K6 14505338 1144760 The inhibitory *effect* of the inhibitor on [MAPK] phosphorylation was , therefore , suggested to counteract the cytoprotective effects of pro-vitamin C via a thorough interruption of the phosphorylated MAPK signaling pathway . Regulation MAPK6 MAP2K6 15064239 1231369 These results suggest that in HTSMCs , LTA stimulated p42/p44 [MAPK] phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , , and PI 3-kinase . Regulation MAPK6 MAP2K6 8550616 346814 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Regulation MAPK6 MAP2K6 9744865 532730 Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 [MAPK] and its *regulation* by the Ste7 . Regulation MAPK6 PECAM1 18029285 1866939 In contrast , expression of Delta15 in PECAM-1-/- bEND cells had minimal *effects* on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Regulation MAPK6 PGC 20955697 2407047 Finally , inhibition of PPAR? activation by a PPAR? antagonist GW9662 abolished the suppressive *effects* of on p38 [MAPK] phosphorylation and VSMC migration . Regulation MAPK6 PLAU 12759445 1091222 There was no *effect* of on LPS induced activation of p38 [mitogen activated protein kinase] in neutrophils . Regulation MAPK6 PLAU 15874933 1405722 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 [MAPK] , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Regulation MAPK6 SPHK1 20498849 2263729 In addition , our results also unraveled a novel *regulation* of [p38MAPK] by during M. smegmatis infection and generation of NO in macrophages . Regulation MAPK6 TLR7 22109714 2568358 The regulatory effect of complement on signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased [mitogen activated protein kinase] and nuclear factor ?B activation . Regulation MAPK6 TLR7 23979601 2850855 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Regulation MAPK6 TNF 10464169 640330 Therefore , both PI 3-K and p38 [MAPK] signaling pathways *control* production in T cells . Regulation MAPK6 TNF 10864897 705707 We therefore investigated the *effects* of and IL-1beta on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK6 TNF 10864897 705759 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK6 TNF 11833090 910327 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of in spleen , and p38 [MAPK] may be *involved* in its signal transduction mechanisms . Regulation MAPK6 TNF 12297009 991068 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Regulation MAPK6 TNF 12297293 991262 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Regulation MAPK6 TNF 12543078 1028763 Together , the p43 induced production was *controlled* by NFkB , p38 [MAPK] , and ERK that is dependent on the activities of PLC and PKC . Regulation MAPK6 TNF 14632659 1170639 In the present study , we analysed the *effects* of and 2,4-dinitrochlorobenzene ( DNCB ) on phenotypic maturation and p38 [mitogen activated protein kinase (MAPK)] activity , using a murine DC line . Regulation MAPK6 TNF 15545827 1337975 The results suggest altered *regulation* of Erk 1/2 and p38 [MAPK] signal translation pathways by endogenously produced , or some compound dependent on TNF may modulate , in part , the phosphorylation state of eIF4E in skeletal muscle during sepsis . Regulation MAPK6 TNF 15792609 1386782 *played* a role in induction of Akt and [MAPK] signals in ameloblastoma . Regulation MAPK6 TNF 16798728 1638551 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Regulation MAPK6 TNF 17031491 1641615 The aim of this study was to investigate the *effects* of stimulation on [MAPK] activation , and the pro- or anti-apoptotic role of these kinases in LNCaP and PC3 cells . Regulation MAPK6 TNF 17074860 1675501 p38 [mitogen activated protein kinase] *controls* NF-kappaB transcriptional activation and alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation MAPK6 TNF 17438131 1742730 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Regulation MAPK6 TNF 19429670 2106839 Then , we examined the *effect* of Ang II and/or on phosphorylation of extracellular signal regulated kinase ( ERK ) , [p38MAPK] , and IkappaB-alpha . Regulation MAPK6 TNF 19648110 2138435 Thus , MKP-1 attenuates *dependent* activation of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Regulation MAPK6 TNF 21949112 2512499 We find that Ga ( i/o ) -mediated activation of the [MAPK] is *independent* of the canonical MyD88 , interleukin-1 receptor associated kinase , and receptor associated factor 6 signaling cascade in LPS stimulated cells . Regulation MAPK6 TNF 22250084 2551237 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Regulation MAPK6 TNF 22988345 2674373 The EGF receptor and HER2 participate in *dependent* [MAPK] activation and IL-8 secretion in intestinal epithelial cells . Regulation MAPK6 TNF 23557259 2777882 The p38 MAPK activation and production were *controlled* by p38 [MAPK] and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation MAPK6 TNF 23861542 2817289 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Regulation MAPK6 TNF 24446489 2912955 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Regulation MAPK6 TNF 8665940 369038 Cell-permeable ceramide analogs mimicked the *effect* on [MAPK] inhibition and PP-2A activation . Regulation MAPK6 TNF 9439626 482912 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic *effect* of requires protein tyrosine phosphorylation and [MAPK] activation . Regulation MAPK6 TNF 9559646 500225 Here , we have studied the *role* of several receptor associated proteins and caspases in p38 [MAPK] activation by TNF . Regulation MAPK6 TNF 9930718 588854 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Regulation MAPK6 TNF 9931102 588947 To identify which receptor is *involved* in TNF-alpha induced [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Regulation MAPK7 ADRB2 19047375 2023501 Hematopoietic protein tyrosine phosphatase mediates induced *regulation* of p38 [mitogen activated protein kinase] in B lymphocytes . Regulation MAPK7 ALOX5 21200133 2391712 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Regulation MAPK7 ANGPT1 24308939 2877811 The functional roles of DUSPs in induced *regulation* of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Regulation MAPK7 CD14 12595465 1061556 The LPS receptor complex utilized by the bladder epithelial cell lines included and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 [mitogen activated protein kinase] . Regulation MAPK7 CTGF 19038999 2023119 Interestingly , did not *affect* the BMP-2/CCN2 induced phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Regulation MAPK7 EDN2 12193071 980988 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Regulation MAPK7 EDN2 8632715 357261 *Effects* of on [mitogen activated protein kinase] activity and protein synthesis in isolated adult feline cardiac myocytes . Regulation MAPK7 EPHB2 10207619 606876 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein are regulated by MAPK/ERK kinases (MEKs) and MEKs , in turn , are *regulated* by [MAPK kinase kinases (MAPKKKs)] . Regulation MAPK7 EPHB2 12486127 1056326 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain had little *effect* on basal Erk [MAPK] activation . Regulation MAPK7 EPHB2 12486127 1056353 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [MAPK] *regulation* plays a significant role in axon guidance . Regulation MAPK7 EPHB2 15149321 1248350 PPAR gamma activity is *regulated* by extracellular signal regulated protein kinase ( ERK ) , [mitogen activated protein (MAP) kinase] , and PPAR gamma ligands have varying effects on activity of . Regulation MAPK7 EPHB2 15683363 1395442 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [MAPK] *regulation* . Regulation MAPK7 EPHB2 16098594 1507106 We , previously , showed that PKC *dependent* [MAPK] activation was inhibited by treating the resting B cell line 38B9 with an anti-MHC class II antibody . Regulation MAPK7 EPHB2 17056059 1649545 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Regulation MAPK7 EPHB2 19428358 2077051 The time-course analysis of PA accumulation and [mitogen activated protein kinase (MAPK)] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation MAPK7 FAS 21613257 2454294 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Regulation MAPK7 FHL1 23456229 2781838 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Regulation MAPK7 GPR115 11916960 946849 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK7 GPR115 15555614 1339813 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK7 GPR132 11916960 946838 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK7 GPR132 15555614 1339802 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK7 GPR87 11916960 946918 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK7 GPR87 15555614 1339882 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK7 ID1 23867624 2821344 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and [MAPK] signaling and gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation MAPK7 IL1B 10864897 705710 We therefore investigated the *effects* of TNF-alpha and on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK7 IL1B 10864897 705762 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK7 IL1B 10969830 728504 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Regulation MAPK7 IL1B 11040101 741909 While IL-1 beta phosphorylated c-Jun N-terminus protein kinase (JNK) rapidly and transiently , the *effect* of on p38 [mitogen activated protein kinase (MAPK)] was gradual and persistent . Regulation MAPK7 IL1B 14563491 1154878 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Regulation MAPK7 IL1B 17390080 1716182 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Regulation MAPK7 IL1B 19685010 2186177 The aim of this study was to compare the *effects* of TNF-alpha , and IFN-gamma on the activation of protein kinase B (PKB) , p70 ( S6k ) , [mitogen activated protein kinase (MAPK)] and p90 ( rsk ) , and on IGF-I stimulated glucose uptake and protein synthesis in mouse C2C12 myotubes . Regulation MAPK7 MAP2K6 10471331 641753 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Regulation MAPK7 MAP2K6 12009309 940949 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Regulation MAPK7 MAP2K6 12637559 1085666 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Regulation MAPK7 MAP2K6 12929129 1132119 The p75 ( NTR ) -induced [MAPK] activation is *dependent* but Raf independent . Regulation MAPK7 MAP2K6 14505338 1144767 The inhibitory *effect* of the inhibitor on [MAPK] phosphorylation was , therefore , suggested to counteract the cytoprotective effects of pro-vitamin C via a thorough interruption of the phosphorylated MAPK signaling pathway . Regulation MAPK7 MAP2K6 15064239 1231378 These results suggest that in HTSMCs , LTA stimulated p42/p44 [MAPK] phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , , and PI 3-kinase . Regulation MAPK7 MAP2K6 8550616 346822 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Regulation MAPK7 MAP2K6 9744865 532737 Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 [MAPK] and its *regulation* by the Ste7 . Regulation MAPK7 PECAM1 18029285 1866940 In contrast , expression of Delta15 in PECAM-1-/- bEND cells had minimal *effects* on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Regulation MAPK7 PGC 20955697 2407048 Finally , inhibition of PPAR? activation by a PPAR? antagonist GW9662 abolished the suppressive *effects* of on p38 [MAPK] phosphorylation and VSMC migration . Regulation MAPK7 PLAU 12759445 1091223 There was no *effect* of on LPS induced activation of p38 [mitogen activated protein kinase] in neutrophils . Regulation MAPK7 PLAU 15874933 1405723 Activation of the [mitogen activated protein kinases (MAPK)] , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Regulation MAPK7 SPHK1 20498849 2263730 In addition , our results also unraveled a novel *regulation* of [p38MAPK] by during M. smegmatis infection and generation of NO in macrophages . Regulation MAPK7 TLR7 22109714 2568368 The regulatory effect of complement on signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased [mitogen activated protein kinase] and nuclear factor ?B activation . Regulation MAPK7 TLR7 23979601 2850865 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Regulation MAPK7 TNF 10464169 640331 Therefore , both PI 3-K and p38 [MAPK] signaling pathways *control* production in T cells . Regulation MAPK7 TNF 10864897 705709 We therefore investigated the *effects* of and IL-1beta on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK7 TNF 10864897 705761 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK7 TNF 11833090 910328 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of in spleen , and p38 [MAPK] may be *involved* in its signal transduction mechanisms . Regulation MAPK7 TNF 12297009 991069 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Regulation MAPK7 TNF 12297293 991263 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Regulation MAPK7 TNF 12543078 1028764 Together , the p43 induced production was *controlled* by NFkB , p38 [MAPK] , and ERK that is dependent on the activities of PLC and PKC . Regulation MAPK7 TNF 14632659 1170640 In the present study , we analysed the *effects* of and 2,4-dinitrochlorobenzene ( DNCB ) on phenotypic maturation and p38 [mitogen activated protein kinase (MAPK)] activity , using a murine DC line . Regulation MAPK7 TNF 15545827 1337976 The results suggest altered *regulation* of Erk 1/2 and p38 [MAPK] signal translation pathways by endogenously produced , or some compound dependent on TNF may modulate , in part , the phosphorylation state of eIF4E in skeletal muscle during sepsis . Regulation MAPK7 TNF 15792609 1386783 *played* a role in induction of Akt and [MAPK] signals in ameloblastoma . Regulation MAPK7 TNF 16798728 1638552 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Regulation MAPK7 TNF 17031491 1641616 The aim of this study was to investigate the *effects* of stimulation on [MAPK] activation , and the pro- or anti-apoptotic role of these kinases in LNCaP and PC3 cells . Regulation MAPK7 TNF 17074860 1675504 p38 [mitogen activated protein kinase] *controls* NF-kappaB transcriptional activation and alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation MAPK7 TNF 17438131 1742731 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Regulation MAPK7 TNF 19429670 2106841 Then , we examined the *effect* of Ang II and/or on phosphorylation of extracellular signal regulated kinase ( ERK ) , [p38MAPK] , and IkappaB-alpha . Regulation MAPK7 TNF 19648110 2138436 Thus , MKP-1 attenuates *dependent* activation of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Regulation MAPK7 TNF 21949112 2512505 We find that Ga ( i/o ) -mediated activation of the [MAPK] is *independent* of the canonical MyD88 , interleukin-1 receptor associated kinase , and receptor associated factor 6 signaling cascade in LPS stimulated cells . Regulation MAPK7 TNF 22250084 2551239 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Regulation MAPK7 TNF 22988345 2674374 The EGF receptor and HER2 participate in *dependent* [MAPK] activation and IL-8 secretion in intestinal epithelial cells . Regulation MAPK7 TNF 23557259 2777885 The p38 MAPK activation and production were *controlled* by p38 [MAPK] and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation MAPK7 TNF 23861542 2817290 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Regulation MAPK7 TNF 24446489 2912956 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Regulation MAPK7 TNF 8665940 369039 Cell-permeable ceramide analogs mimicked the *effect* on [MAPK] inhibition and PP-2A activation . Regulation MAPK7 TNF 9439626 482913 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic *effect* of requires protein tyrosine phosphorylation and [MAPK] activation . Regulation MAPK7 TNF 9559646 500226 Here , we have studied the *role* of several receptor associated proteins and caspases in p38 [MAPK] activation by TNF . Regulation MAPK7 TNF 9930718 588855 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Regulation MAPK7 TNF 9931102 588948 To identify which receptor is *involved* in TNF-alpha induced [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Regulation MAPK8 ADRB2 19047375 2023502 Hematopoietic protein tyrosine phosphatase mediates induced *regulation* of p38 [mitogen activated protein kinase] in B lymphocytes . Regulation MAPK8 ALOX5 21200133 2391713 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Regulation MAPK8 ANGPT1 24308939 2877812 The functional roles of DUSPs in induced *regulation* of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Regulation MAPK8 CD14 12595465 1061557 The LPS receptor complex utilized by the bladder epithelial cell lines included and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 [mitogen activated protein kinase] . Regulation MAPK8 CTGF 19038999 2023121 Interestingly , did not *affect* the BMP-2/CCN2 induced phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Regulation MAPK8 EDN2 12193071 980991 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Regulation MAPK8 EDN2 8632715 357264 *Effects* of on [mitogen activated protein kinase] activity and protein synthesis in isolated adult feline cardiac myocytes . Regulation MAPK8 EPHB2 10207619 606877 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein are regulated by MAPK/ERK kinases (MEKs) and MEKs , in turn , are *regulated* by [MAPK kinase kinases (MAPKKKs)] . Regulation MAPK8 EPHB2 10650934 662418 The use of PD98059 , which inhibits activation of ERK1 and -2 , and LY 294002 , an inhibitor of phosphatidylinositol 3-kinase , demonstrated that IGF-I induced activation of [JNK1] is *independent* of and phosphatidylinositol 3-kinase activation . Regulation MAPK8 EPHB2 12486127 1056327 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain had little *effect* on basal Erk [MAPK] activation . Regulation MAPK8 EPHB2 12486127 1056354 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [MAPK] *regulation* plays a significant role in axon guidance . Regulation MAPK8 EPHB2 15149321 1248351 PPAR gamma activity is *regulated* by extracellular signal regulated protein kinase ( ERK ) , [mitogen activated protein (MAP) kinase] , and PPAR gamma ligands have varying effects on activity of . Regulation MAPK8 EPHB2 15683363 1395443 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [MAPK] *regulation* . Regulation MAPK8 EPHB2 16098594 1507108 We , previously , showed that PKC *dependent* [MAPK] activation was inhibited by treating the resting B cell line 38B9 with an anti-MHC class II antibody . Regulation MAPK8 EPHB2 17056059 1649546 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Regulation MAPK8 EPHB2 19428358 2077052 The time-course analysis of PA accumulation and [mitogen activated protein kinase (MAPK)] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation MAPK8 FAS 21613257 2454295 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Regulation MAPK8 FHL1 23456229 2781839 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Regulation MAPK8 GPR115 11916960 946942 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK8 GPR115 15555614 1339906 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK8 GPR132 11916960 946931 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK8 GPR132 15555614 1339895 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK8 GPR87 11916960 947011 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK8 GPR87 15555614 1339975 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK8 ID1 23867624 2821345 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and [MAPK] signaling and gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation MAPK8 IL1B 10864897 705712 We therefore investigated the *effects* of TNF-alpha and on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK8 IL1B 10864897 705764 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK8 IL1B 10969830 728505 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Regulation MAPK8 IL1B 11040101 741910 While IL-1 beta phosphorylated c-Jun N-terminus protein kinase (JNK) rapidly and transiently , the *effect* of on p38 [mitogen activated protein kinase (MAPK)] was gradual and persistent . Regulation MAPK8 IL1B 14563491 1154879 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Regulation MAPK8 IL1B 17390080 1716183 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Regulation MAPK8 IL1B 19685010 2186179 The aim of this study was to compare the *effects* of TNF-alpha , and IFN-gamma on the activation of protein kinase B (PKB) , p70 ( S6k ) , [mitogen activated protein kinase (MAPK)] and p90 ( rsk ) , and on IGF-I stimulated glucose uptake and protein synthesis in mouse C2C12 myotubes . Regulation MAPK8 MAP2K6 10471331 641760 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Regulation MAPK8 MAP2K6 12009309 940956 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Regulation MAPK8 MAP2K6 12637559 1085676 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Regulation MAPK8 MAP2K6 12929129 1132126 The p75 ( NTR ) -induced [MAPK] activation is *dependent* but Raf independent . Regulation MAPK8 MAP2K6 14505338 1144774 The inhibitory *effect* of the inhibitor on [MAPK] phosphorylation was , therefore , suggested to counteract the cytoprotective effects of pro-vitamin C via a thorough interruption of the phosphorylated MAPK signaling pathway . Regulation MAPK8 MAP2K6 15064239 1231387 These results suggest that in HTSMCs , LTA stimulated p42/p44 [MAPK] phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , , and PI 3-kinase . Regulation MAPK8 MAP2K6 8550616 346830 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Regulation MAPK8 MAP2K6 9744865 532744 Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 [MAPK] and its *regulation* by the Ste7 . Regulation MAPK8 PECAM1 18029285 1866941 In contrast , expression of Delta15 in PECAM-1-/- bEND cells had minimal *effects* on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Regulation MAPK8 PGC 20955697 2407049 Finally , inhibition of PPAR? activation by a PPAR? antagonist GW9662 abolished the suppressive *effects* of on p38 [MAPK] phosphorylation and VSMC migration . Regulation MAPK8 PLAU 12759445 1091224 There was no *effect* of on LPS induced activation of p38 [mitogen activated protein kinase] in neutrophils . Regulation MAPK8 PLAU 15874933 1405724 Activation of the mitogen activated protein kinases (MAPK) , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 [MAPK] , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Regulation MAPK8 SPHK1 20498849 2263731 In addition , our results also unraveled a novel *regulation* of [p38MAPK] by during M. smegmatis infection and generation of NO in macrophages . Regulation MAPK8 TLR7 22109714 2568378 The regulatory effect of complement on signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased [mitogen activated protein kinase] and nuclear factor ?B activation . Regulation MAPK8 TLR7 23979601 2850875 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Regulation MAPK8 TNF 10464169 640332 Therefore , both PI 3-K and p38 [MAPK] signaling pathways *control* production in T cells . Regulation MAPK8 TNF 10864897 705711 We therefore investigated the *effects* of and IL-1beta on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK8 TNF 10864897 705763 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK8 TNF 11833090 910329 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of in spleen , and p38 [MAPK] may be *involved* in its signal transduction mechanisms . Regulation MAPK8 TNF 12297009 991070 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Regulation MAPK8 TNF 12297293 991264 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Regulation MAPK8 TNF 12543078 1028765 Together , the p43 induced production was *controlled* by NFkB , p38 [MAPK] , and ERK that is dependent on the activities of PLC and PKC . Regulation MAPK8 TNF 14632659 1170641 In the present study , we analysed the *effects* of and 2,4-dinitrochlorobenzene ( DNCB ) on phenotypic maturation and p38 [mitogen activated protein kinase (MAPK)] activity , using a murine DC line . Regulation MAPK8 TNF 15545827 1337977 The results suggest altered *regulation* of Erk 1/2 and p38 [MAPK] signal translation pathways by endogenously produced , or some compound dependent on TNF may modulate , in part , the phosphorylation state of eIF4E in skeletal muscle during sepsis . Regulation MAPK8 TNF 15629131 1362200 While [JNK1] is a downstream *effector* of the signaling , Zfra regulation of the TNF cytotoxic function is likely due to its interaction , in part , with JNK1 . Regulation MAPK8 TNF 15792609 1386784 *played* a role in induction of Akt and [MAPK] signals in ameloblastoma . Regulation MAPK8 TNF 16798728 1638553 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Regulation MAPK8 TNF 17031491 1641617 The aim of this study was to investigate the *effects* of stimulation on [MAPK] activation , and the pro- or anti-apoptotic role of these kinases in LNCaP and PC3 cells . Regulation MAPK8 TNF 17074860 1675507 p38 [mitogen activated protein kinase] *controls* NF-kappaB transcriptional activation and alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation MAPK8 TNF 17438131 1742732 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Regulation MAPK8 TNF 17500068 1761796 TNFR1 , but not TNFR2 , also mediates a potent *effect* of on the phosphorylation of [JNK1/2] and p38 stress activated protein kinase and their downstream transcription factor substrates c-Jun and activating transcription factor 2 ( ATF2 ) . Regulation MAPK8 TNF 17567906 1763227 In *response* to , Zfra is upregulated and modulates TNF mediated cell death via interacting with TRADD , FADD and RIP ( death inducing signaling complex ) at the receptor level , and downstream effectors NF-kappaB , p53 , WOX1 , and [JNK1] . Regulation MAPK8 TNF 19429670 2106843 Then , we examined the *effect* of Ang II and/or on phosphorylation of extracellular signal regulated kinase ( ERK ) , [p38MAPK] , and IkappaB-alpha . Regulation MAPK8 TNF 19648110 2138437 Thus , MKP-1 attenuates *dependent* activation of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Regulation MAPK8 TNF 21949112 2512511 We find that Ga ( i/o ) -mediated activation of the [MAPK] is *independent* of the canonical MyD88 , interleukin-1 receptor associated kinase , and receptor associated factor 6 signaling cascade in LPS stimulated cells . Regulation MAPK8 TNF 22250084 2551241 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Regulation MAPK8 TNF 22988345 2674375 The EGF receptor and HER2 participate in *dependent* [MAPK] activation and IL-8 secretion in intestinal epithelial cells . Regulation MAPK8 TNF 23557259 2777888 The p38 MAPK activation and production were *controlled* by p38 [MAPK] and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation MAPK8 TNF 23651848 2805311 Rather , sTWEAK abolishes the stimulatory *effect* of on [JNK1/2] , which is directly involved in the development of insulin resistance . Regulation MAPK8 TNF 23861542 2817291 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Regulation MAPK8 TNF 24446489 2912957 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Regulation MAPK8 TNF 8665940 369040 Cell-permeable ceramide analogs mimicked the *effect* on [MAPK] inhibition and PP-2A activation . Regulation MAPK8 TNF 9439626 482914 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic *effect* of requires protein tyrosine phosphorylation and [MAPK] activation . Regulation MAPK8 TNF 9559646 500227 Here , we have studied the *role* of several receptor associated proteins and caspases in p38 [MAPK] activation by TNF . Regulation MAPK8 TNF 9930718 588856 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Regulation MAPK8 TNF 9931102 588949 To identify which receptor is *involved* in TNF-alpha induced [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Regulation MAPK9 ADRB2 19047375 2023503 Hematopoietic protein tyrosine phosphatase mediates induced *regulation* of p38 [mitogen activated protein kinase] in B lymphocytes . Regulation MAPK9 ALOX5 21200133 2391714 We describe an alternative ROS production pathway that is triggered by CD40 ligation , *involves* <5-lipoxygenase (5-LO)> , and results in activation of p38 [MAPK] . Regulation MAPK9 ANGPT1 24308939 2877813 The functional roles of DUSPs in induced *regulation* of [MAPK] activation , endothelial cell survival , migration , differentiation , and permeability were measured using selective siRNA oligos . Regulation MAPK9 CD14 12595465 1061558 The LPS receptor complex utilized by the bladder epithelial cell lines included and Toll-like receptors , and signaling *involved* the activation of NF-kappaB and p38 [mitogen activated protein kinase] . Regulation MAPK9 CTGF 19038999 2023123 Interestingly , did not *affect* the BMP-2/CCN2 induced phosphorylation of p38 [MAPK] but caused less phosphorylation of ERK1/2 in cultured chondrocytes . Regulation MAPK9 EDN2 12193071 980994 The molecular mechanisms of *dependent* activation of extracellular signal regulated kinase ( ERK ) and p38 [mitogen activated protein (MAP) kinase] were studied in rat and human renal glomerular mesangial cells . Regulation MAPK9 EDN2 8632715 357267 *Effects* of on [mitogen activated protein kinase] activity and protein synthesis in isolated adult feline cardiac myocytes . Regulation MAPK9 EPHB2 10207619 606878 ERK/MAPK pathways are comprised of a three tiered core signalling module wherein are regulated by MAPK/ERK kinases (MEKs) and MEKs , in turn , are *regulated* by [MAPK kinase kinases (MAPKKKs)] . Regulation MAPK9 EPHB2 12486127 1056328 An mutant that retained juxtamembrane ( JM ) RasGAP binding sites but incorporated a Grb2 binding motif at an alternate RasGAP binding site within the kinase domain had little *effect* on basal Erk [MAPK] activation . Regulation MAPK9 EPHB2 12486127 1056355 These data suggest that EphB2 can be designed to repress , stabilize , or activate the Ras-Erk MAPK pathway by the manipulation of RasGAP and Grb2 SH2 domain binding sites and support the notion that [MAPK] *regulation* plays a significant role in axon guidance . Regulation MAPK9 EPHB2 15149321 1248352 PPAR gamma activity is *regulated* by extracellular signal regulated protein kinase ( ERK ) , [mitogen activated protein (MAP) kinase] , and PPAR gamma ligands have varying effects on activity of . Regulation MAPK9 EPHB2 15683363 1395444 The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of [MAPK] *regulation* . Regulation MAPK9 EPHB2 16098594 1507110 We , previously , showed that PKC *dependent* [MAPK] activation was inhibited by treating the resting B cell line 38B9 with an anti-MHC class II antibody . Regulation MAPK9 EPHB2 17056059 1649547 Previously , we showed that chilling of diapausing Bombyx eggs activated [ERK/MAPK] in yolk cells coincidentally with acquisition of developmental competence , and that *regulates* diapause termination via activating transcription of key enzyme genes for ecdysteroid and sorbitol metabolism . Regulation MAPK9 EPHB2 19428358 2077053 The time-course analysis of PA accumulation and [mitogen activated protein kinase (MAPK)] *regulation* indicated PA generation preceded MAPK activation , suggesting that the rapid accumulation of PA might be required for the initial MAPK activity . Regulation MAPK9 FAS 21613257 2454296 In *response* to and TNFa , Toso promotes the activation of [MAPK] and NF-?B signaling pathways . Regulation MAPK9 FHL1 23456229 2781840 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Regulation MAPK9 GPR115 11916960 947035 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK9 GPR115 15555614 1339999 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK9 GPR132 11916960 947024 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK9 GPR132 15555614 1339988 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK9 GPR87 11916960 947104 Although Gbetagamma is thought to mediate [mitogen activated protein kinase (MAPK)] activation in *response* to stimulation , the mechanisms involved in this pathway have not been clearly defined . Regulation MAPK9 GPR87 15555614 1340068 This is the first description of differential [MAPK] *regulation* by a through the rho pathway . Regulation MAPK9 ID1 23867624 2821346 FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1) , ALK2 , and ALK3 and activated downstream SMAD1/5 and [MAPK] signaling and gene *regulation* in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin . Regulation MAPK9 IL1B 10864897 705714 We therefore investigated the *effects* of TNF-alpha and on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK9 IL1B 10864897 705766 In *response* to TNF-alpha and , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK9 IL1B 10969830 728506 In conclusion , increased [MAPK] signaling in *response* to may represent a novel molecular marker of beta-cell differentiation . Regulation MAPK9 IL1B 11040101 741911 While IL-1 beta phosphorylated c-Jun N-terminus protein kinase (JNK) rapidly and transiently , the *effect* of on p38 [mitogen activated protein kinase (MAPK)] was gradual and persistent . Regulation MAPK9 IL1B 14563491 1154880 Western blot analysis indicated that CMT-8 did not affect p38 [mitogen activated protein kinase] , c-jun NH ( 2 ) -terminal kinases , or extracellular signal regulated kinases ( 1 and 2 ) phosphorylation in *response* to . Regulation MAPK9 IL1B 17390080 1716184 Addition of triptolide did not suppress activation of p38 [MAPK] , JNK , or PI3K in *response* to . Regulation MAPK9 IL1B 19685010 2186181 The aim of this study was to compare the *effects* of TNF-alpha , and IFN-gamma on the activation of protein kinase B (PKB) , p70 ( S6k ) , [mitogen activated protein kinase (MAPK)] and p90 ( rsk ) , and on IGF-I stimulated glucose uptake and protein synthesis in mouse C2C12 myotubes . Regulation MAPK9 MAP2K6 10471331 641767 PD098059 ) we demonstrated that CNTF induced Stat3 transactivation was independent of the p21ras-mitogen activated protein kinase (MAPK) pathway , while CNTF induced [MAPK] activation was p21ras- and *dependent* . Regulation MAPK9 MAP2K6 12009309 940963 Western blot analyses of cells treated with specific inhibitors were also performed to determine whether PKC isoforms or were *involved* in activation of [MAPK] . Regulation MAPK9 MAP2K6 12637559 1085686 Although HDL induced activation of [MAPK] *involves* Raf-1 , , and Erk1/2 , the upstream contribution of p21(ras) (Ras) on the activation of Raf-1 and MAPK remains elusive . Regulation MAPK9 MAP2K6 12929129 1132133 The p75 ( NTR ) -induced [MAPK] activation is *dependent* but Raf independent . Regulation MAPK9 MAP2K6 14505338 1144781 The inhibitory *effect* of the inhibitor on [MAPK] phosphorylation was , therefore , suggested to counteract the cytoprotective effects of pro-vitamin C via a thorough interruption of the phosphorylated MAPK signaling pathway . Regulation MAPK9 MAP2K6 15064239 1231396 These results suggest that in HTSMCs , LTA stimulated p42/p44 [MAPK] phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , , and PI 3-kinase . Regulation MAPK9 MAP2K6 8550616 346838 [MAPK] is tightly *regulated* by the activating kinase , , and specific phosphatase MKP-1 . Regulation MAPK9 MAP2K6 9744865 532751 Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 [MAPK] and its *regulation* by the Ste7 . Regulation MAPK9 PECAM1 18029285 1866942 In contrast , expression of Delta15 in PECAM-1-/- bEND cells had minimal *effects* on their activation of [MAPK/ERKs] , migration , and capillary morphogenesis . Regulation MAPK9 PGC 20955697 2407050 Finally , inhibition of PPAR? activation by a PPAR? antagonist GW9662 abolished the suppressive *effects* of on p38 [MAPK] phosphorylation and VSMC migration . Regulation MAPK9 PLAU 12759445 1091225 There was no *effect* of on LPS induced activation of p38 [mitogen activated protein kinase] in neutrophils . Regulation MAPK9 PLAU 15874933 1405725 Activation of the [mitogen activated protein kinases (MAPK)] , extracellular signal regulated kinase 1/2 ( ERK1/2 ) , p38 MAPK , Akt , MAP kinase/ERK kinase ( MEK1/2 ) , MAP kinase kinase (MKK)3/6 , and epidermal growth factor receptor (EGFR) in *response* to was assayed by Western blot analysis for the phosphorylated form of each kinase . Regulation MAPK9 SPHK1 20498849 2263732 In addition , our results also unraveled a novel *regulation* of [p38MAPK] by during M. smegmatis infection and generation of NO in macrophages . Regulation MAPK9 TLR7 22109714 2568388 The regulatory effect of complement on signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased [mitogen activated protein kinase] and nuclear factor ?B activation . Regulation MAPK9 TLR7 23979601 2850885 Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 [mitogen activated protein kinase (MAPK)] signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Regulation MAPK9 TNF 10464169 640333 Therefore , both PI 3-K and p38 [MAPK] signaling pathways *control* production in T cells . Regulation MAPK9 TNF 10864897 705713 We therefore investigated the *effects* of and IL-1beta on cell proliferation and activation of p42/p44 [mitogen activated protein kinase (MAPK)] in these cells . Regulation MAPK9 TNF 10864897 705765 In *response* to and IL-1beta , p42/p44 [MAPK] was activated with a concentration dependent manner in TSMCs . Regulation MAPK9 TNF 11833090 910330 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of in spleen , and p38 [MAPK] may be *involved* in its signal transduction mechanisms . Regulation MAPK9 TNF 12297009 991071 The phosphorylation of p38 [MAPK] in *response* to slowly increased and lasted several hours in the PC12 cell and DRG neuron . Regulation MAPK9 TNF 12297293 991265 Phosphorylation of p38 [MAPK] was decreased in *response* to , and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels . Regulation MAPK9 TNF 12543078 1028766 Together , the p43 induced production was *controlled* by NFkB , p38 [MAPK] , and ERK that is dependent on the activities of PLC and PKC . Regulation MAPK9 TNF 12665585 1074941 To examine the role of the JNK signaling pathway , we compared the *effects* of on wild-type and Jnk1 ( -/- ) [Jnk2] ( -/- ) murine embryo fibroblasts . Regulation MAPK9 TNF 14632659 1170642 In the present study , we analysed the *effects* of and 2,4-dinitrochlorobenzene ( DNCB ) on phenotypic maturation and p38 [mitogen activated protein kinase (MAPK)] activity , using a murine DC line . Regulation MAPK9 TNF 15545827 1337978 The results suggest altered *regulation* of Erk 1/2 and p38 [MAPK] signal translation pathways by endogenously produced , or some compound dependent on TNF may modulate , in part , the phosphorylation state of eIF4E in skeletal muscle during sepsis . Regulation MAPK9 TNF 15792609 1386785 *played* a role in induction of Akt and [MAPK] signals in ameloblastoma . Regulation MAPK9 TNF 16798728 1638554 Although p38 [MAPK] is activated in *response* to , inhibition of p38 MAPK did not decrease apoptosis . Regulation MAPK9 TNF 17031491 1641618 The aim of this study was to investigate the *effects* of stimulation on [MAPK] activation , and the pro- or anti-apoptotic role of these kinases in LNCaP and PC3 cells . Regulation MAPK9 TNF 17074860 1675510 p38 [mitogen activated protein kinase] *controls* NF-kappaB transcriptional activation and alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation MAPK9 TNF 17438131 1742733 Overexpression of alpha-4 suppressed p38 [MAPK] activation in *response* to . Regulation MAPK9 TNF 19429670 2106845 Then , we examined the *effect* of Ang II and/or on phosphorylation of extracellular signal regulated kinase ( ERK ) , [p38MAPK] , and IkappaB-alpha . Regulation MAPK9 TNF 19648110 2138438 Thus , MKP-1 attenuates *dependent* activation of p38 [MAPK] , induction of IL-8 expression , and NF-kappaB dependent transcription . Regulation MAPK9 TNF 21949112 2512517 We find that Ga ( i/o ) -mediated activation of the [MAPK] is *independent* of the canonical MyD88 , interleukin-1 receptor associated kinase , and receptor associated factor 6 signaling cascade in LPS stimulated cells . Regulation MAPK9 TNF 22250084 2551243 However , overexpression of MUC1 in HEK293 cells did not affect NF-?B or [MAPK] activation in *response* to . Regulation MAPK9 TNF 22988345 2674376 The EGF receptor and HER2 participate in *dependent* [MAPK] activation and IL-8 secretion in intestinal epithelial cells . Regulation MAPK9 TNF 23557259 2777891 The p38 MAPK activation and production were *controlled* by p38 [MAPK] and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation MAPK9 TNF 23861542 2817292 ROCK1 dependent release of myosin was necessary for the *dependent* recruitment of TRAF2 to p75 and for p75-specific activation of NF-?B and [MAPK] signaling . Regulation MAPK9 TNF 24446489 2912958 Specifically , loss of BMPR2 induced prolonged phospho-p38 [mitogen activated protein kinase (MAPK)] in *response* to , and this increased GADD34-PP1 phosphatase activity , dephosphorylating eukaryotic translation initiation factor ( eIF2a ) , and derepressing GM-CSF mRNA translation . Regulation MAPK9 TNF 8665940 369041 Cell-permeable ceramide analogs mimicked the *effect* on [MAPK] inhibition and PP-2A activation . Regulation MAPK9 TNF 9439626 482915 These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic *effect* of requires protein tyrosine phosphorylation and [MAPK] activation . Regulation MAPK9 TNF 9559646 500228 Here , we have studied the *role* of several receptor associated proteins and caspases in p38 [MAPK] activation by TNF . Regulation MAPK9 TNF 9930718 588857 In contrast , IFN gamma neither activated on its own nor enhanced the activation of p38 [MAPK] in *response* to and IL-1 . Regulation MAPK9 TNF 9931102 588950 To identify which receptor is *involved* in TNF-alpha induced [MAPK] activation , antibodies against the p55 TNF-alpha receptor-1 (TNF-R1) and the p75 TNF-alpha receptor-2 (TNF-R2) were used . Regulation MAPKAPK2 TNF 24046015 2857399 and ( 3 ) although overexpression in FA cells is *controlled* posttranscriptionally by the p38 substrate [MAPKAPK-2] , p38 dependent overproduction of IL-1ß is controlled transcriptionally . Regulation MAPRE1 STK39 18083840 1837887 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation MARCKSL1 HES2 16247329 1471599 had no *effect* on the normal [f-MLP] dose dependent increase in PMN activation . Regulation MARCO TLR7 16525990 1541896 We propose that the *dependent* induction of [MARCO] by innate immune stimulation enhances recognition and uptake of pathogenic organisms such as NM , thus contributing to host defence against infection . Regulation MARK2 DAPK1 23948915 2850282 The phosphorylation level of microtubule affinity regulating kinase 2 ( MARK2 ) was increased by expression of , but simultaneous downregulation of [MARK2] did not *affect* the DAPK1 induced tau hyperphosphorylation . Regulation MASP1 IL1B 12356684 993996 The stimulatory *effects* of on [MASP1/3] and MASP2 gene expression were abolished by the simultaneous presence of IL-6 . Regulation MASP2 IL1B 12356684 993997 The stimulatory *effects* of on MASP1/3 and [MASP2] gene expression were abolished by the simultaneous presence of IL-6 . Regulation MAST1 TNF 19664126 2119331 [Mast] cell migratory *responses* to IL-6 and were entirely blocked by specific anti-IL-6R and anti-TNFR1 antibodies . Regulation MAST2 TNF 19664126 2119333 [Mast] cell migratory *responses* to IL-6 and were entirely blocked by specific anti-IL-6R and anti-TNFR1 antibodies . Regulation MAST3 TNF 19664126 2119335 [Mast] cell migratory *responses* to IL-6 and were entirely blocked by specific anti-IL-6R and anti-TNFR1 antibodies . Regulation MAST4 TNF 19664126 2119337 [Mast] cell migratory *responses* to IL-6 and were entirely blocked by specific anti-IL-6R and anti-TNFR1 antibodies . Regulation MATN2 BMP7 18328806 1891933 *dependent* expression of [matrilin-2] is involved in keratinocyte migration in response to wounding . Regulation MB CAPN8 24256333 2921210 Using a microdialysis technique in the hearts of anaesthetized rats , we investigated the *effects* of the inhibitors on myocardial interstitial [myoglobin] level in the ischaemic region during coronary occlusion and after reperfusion . Regulation MBP EDN2 8130126 242070 The present results suggest that endogenous is active at low levels under normal conditions and that this peptide *plays* a role in the physiological control of renal function , but not [MBP] . Regulation MBP PGC 21715619 2447226 Chromatin immunoprecipitations revealed the recruitment of PGC1a to MBP promoter in mouse brain , and PGC1a over-expression increased MBP and SREBP-2 promoter activity , suggesting that *regulates* [MBP] and cholesterol synthesis at the transcriptional level . Regulation MBP TF 12401963 1009362 *regulates* transcription of the [MBP] gene and its action synergizes with IGF-1 to enhance myelinogenesis in the md rat . Regulation MBP TF 12401963 1009363 Thus , selectively *regulates* [MBP] at the transcriptional level and together with IGF-1 synergizes to increase both the maturation and myelinogenic properties of md and normal OL . Regulation MBP TNF 12175864 975188 Elucidating the molecular mechanisms underlying *regulation* of [MBP] gene expression provides new scientific bases for the development of therapy against oligodendrocyte-specific and myelin related disorders such as multiple sclerosis . Regulation MBP TNF 18808689 1969867 Corticosterone , dihydrocorticosterone and , most prominently dexamethasone , counteracted the deleterious *effects* of IFN-gamma and on cell survival , A2B5 immunostaining and expression of [myelin basic protein] . Regulation MBS1 AXIN2 17373666 1741398 To study the functional *role* of in [MBs] , wild-type AXIN2 was overexpressed in MB cell lines in which the Wnt signaling pathway was activated by Wnt-3a . Regulation MBTPS1 CAPN8 22002053 2513180 [S1P] and WSS synergistically activated MT1-MMP and induced cell membrane localization of MT1-MMP in a *dependent* manner . Regulation MBTPS1 SPHK1 15289497 1278463 In this paper , we report that in PC12 cells and dorsal root ganglion neurons , NGF translocates SphK1 to the plasma membrane and differentially activates the [S1P] receptors S1P1 and S1P2 in a *dependent* manner , as determined with specific inhibitors and small interfering RNA targeted to SphK1 . Regulation MBTPS1 SPHK1 17320845 1706312 Activation of , which has two known isoforms , is *responsible* for the synthesis of [sphingosine 1-phosphate (S1P)] , a cell survival factor . Regulation MCAM TNF 19229070 2054637 Our results demonstrate that [CD146] is *regulated* by the inflammatory cytokine and that CD146 and sCD146 are both involved in monocyte transendothelial migration during inflammation . Regulation MCAM TNF 24200306 2864460 The biological *effects* of on [CD146±PDLCs] were evaluated by CCK-8 assay ( proliferation ) , DAPI staining ( apoptosis ) , alizarin red staining and alkaline phosphatase activities assay ( osteogenesis ) , and wounding assay and transwell assay ( migration ) . Regulation MCL1 EPHB2 15753661 1464948 We find that epidermal growth factor (EGF) can enhance [Mcl-1] protein levels in an *dependent* manner . Regulation MCL1 EPHB2 16327976 1503570 Furthermore , the hepatocyte growth factor and epidermal growth factor induced [Mcl-1] expression in an Akt- and *dependent* manner . Regulation MCL1 EPHB2 16761109 1585444 [MCL1] expression was constitutively elevated in multiple myeloma cell lines , and was not *affected* by or MTDAs . Regulation MCL1 EPHB2 17890680 1843626 Analysis of Bcl-2 family proteins revealed phosphorylation of Bad at serine 112 as well as *dependent* inhibition of [Mcl-1] degradation . Regulation MCL1 EPHB2 19092849 2053646 Treatment with R406 induced leukemic cell apoptosis in the majority of investigated cases and affected the basal activity or expression of several pro-survival molecules regulated by Syk , including the Akt and extracellular signal *regulated* ( ) kinases , and the anti-apoptotic protein [Mcl-1] . Regulation MCL1 EPHB2 19622586 2112609 Overexpression of mitogen activated protein/ERK kinase ( MEK ) partially reversed the effect of EPOX on Mcl-1 dephosphorylation , ubiquitination , and degradation , further implicating in the *regulation* of [Mcl-1] stability . Regulation MCL1 EPHB2 24263101 2869760 Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal *dependent* suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of [Mcl-1] . Regulation MCL1 TNF 17942758 1849464 While had no *effect* on [MCL-1] transcription , it induced expression of another antiapoptotic molecule , BFL-1 . Regulation MCOLN1 ADRB2 7554152 327524 Differential *regulation* of circulating [Mg2+] in the rat by beta 1- and stimulation . Regulation MDM1 TLR7 20084270 2194544 PMAr cells retained a high phagocytic capacity for latex beads , and expressed a cytokine profile that resembled [MDM] in *response* to ligands , in particular with marked TLR2 responses . Regulation MDM2 EPHB2 15723837 1396184 signaling *controls* [Hdm2] oncoprotein expression by regulating hdm2 mRNA export to the cytoplasm . Regulation MDM2 EPHB2 15723837 1396204 Growth and survival factor activated signaling can also *regulate* [Hdm2] expression independently of p53 , contributing to the pro-survival effect of these factors . Regulation MDM2 MAP2K6 15723837 1396190 signaling *controls* [Hdm2] oncoprotein expression by regulating hdm2 mRNA export to the cytoplasm . Regulation MDM2 MAP2K6 15723837 1396210 Growth and survival factor activated signaling can also *regulate* [Hdm2] expression independently of p53 , contributing to the pro-survival effect of these factors . Regulation MDM2 MAP2K6 15723837 1396225 Here we show that , in human breast cancer epithelial cells , dependent *regulation* of [Hdm2] expression also occurs at a post-transcriptional level . Regulation MDM2 TLR7 20084270 2194554 PMAr cells retained a high phagocytic capacity for latex beads , and expressed a cytokine profile that resembled [MDM] in *response* to ligands , in particular with marked TLR2 responses . Regulation MDM2 TNF 12189181 979959 potentiated the cadmium induced accumulation of p53 but did not *affect* expression levels of Bax , [Mdm2] and p21 ( WAF/CIP ) . Regulation MDM2 TP63 12374749 996675 Over expression of wild-type , but not deletion mutant , SSRP1 remarkably enhanced *dependent* luciferase activity , G1 arrest , apoptosis and expression of endogenous PIG3 , p21 ( Waf1/cip1 ) and [MDM2] in human p53-deficient lung carcinoma H1299 cells and mouse embryonic fibroblasts . Regulation MDM4 TLR7 20084270 2194564 PMAr cells retained a high phagocytic capacity for latex beads , and expressed a cytokine profile that resembled [MDM] in *response* to ligands , in particular with marked TLR2 responses . Regulation MED1 ALOX5 1701029 144997 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED1 CD14 12435950 1016116 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED1 EPHB2 16314496 1487051 ERK phosphorylation of ectopic TRAP220/Med1 also triggered shuttling into the nucleolus , thus suggesting that may *regulate* [TRAP220/Med1] subnuclear localization . Regulation MED1 EPHB2 19755425 2158641 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Regulation MED1 F2R 19205424 2007303 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED1 F2R 9141614 428507 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED1 IL1B 11132773 760342 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED1 LBP 12435950 1016117 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED1 TF 2440461 74303 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED1 TLR7 17264163 1733104 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED1 TLR7 18584038 1931115 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED1 TNF 11132773 760341 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED1 TNF 14550746 1152784 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED1 TNF 16945012 1609928 Compound 1 did not affect the or lipopolysaccharide induced [TRAP-luciferase] *response* , suggesting selective inhibition of the RANKL induced pathway . Regulation MED1 TNF 17307735 1719146 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED1 TNF 17988550 1821564 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED1 TNF 18768838 1957109 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED1 TNF 23630580 2779104 SIMPL enhancement of *dependent* [p65-MED1] complex formation is required for mammalian hematopoietic stem and progenitor cell function . Regulation MED10 ALOX5 1701029 144992 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED10 CD14 12435950 1016106 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED10 F2R 19205424 2007298 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED10 F2R 9141614 428502 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED10 IL1B 11132773 760332 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED10 LBP 12435950 1016107 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED10 TF 2440461 74299 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED10 TLR7 17264163 1733099 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED10 TLR7 18584038 1931065 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED10 TNF 11132773 760331 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED10 TNF 14550746 1152780 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED10 TNF 17307735 1719142 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED10 TNF 17988550 1821560 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED10 TNF 18768838 1957104 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED11 ALOX5 1701029 144995 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED11 CD14 12435950 1016112 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED11 F2R 19205424 2007301 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED11 F2R 9141614 428505 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED11 IL1B 11132773 760338 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED11 LBP 12435950 1016113 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED11 TF 2440461 74302 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED11 TLR7 17264163 1733102 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED11 TLR7 18584038 1931095 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED11 TNF 11132773 760337 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED11 TNF 14550746 1152783 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED11 TNF 17307735 1719145 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED11 TNF 17988550 1821563 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED11 TNF 18768838 1957107 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED12 EPHB2 19755425 2158613 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Regulation MED12 TF 2440461 74274 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED12 TNF 14550746 1152755 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED12 TNF 16945012 1609922 Compound 1 did not affect the or lipopolysaccharide induced [TRAP-luciferase] *response* , suggesting selective inhibition of the RANKL induced pathway . Regulation MED12 TNF 17307735 1719117 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED12 TNF 17988550 1821535 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED13 ALOX5 1701029 144979 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED13 CD14 12435950 1016080 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED13 EPHB2 19755425 2158623 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Regulation MED13 F2R 19205424 2007285 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED13 F2R 9141614 428489 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED13 IL1B 11132773 760306 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED13 LBP 12435950 1016081 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED13 TF 2440461 74284 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED13 TLR7 17264163 1733086 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED13 TLR7 18584038 1930935 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED13 TNF 11132773 760305 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED13 TNF 14550746 1152765 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED13 TNF 17307735 1719127 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED13 TNF 17988550 1821545 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED13 TNF 18768838 1957091 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED13L ALOX5 1701029 144980 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED13L CD14 12435950 1016082 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED13L F2R 19205424 2007286 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED13L F2R 9141614 428490 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED13L IL1B 11132773 760308 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED13L LBP 12435950 1016083 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED13L TF 2440461 74285 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED13L TLR7 17264163 1733087 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED13L TLR7 18584038 1930945 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED13L TNF 11132773 760307 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED13L TNF 14550746 1152766 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED13L TNF 17307735 1719128 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED13L TNF 17988550 1821546 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED13L TNF 18768838 1957092 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED14 ALOX5 1701029 144984 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED14 CD14 12435950 1016090 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED14 EPHB2 19755425 2158627 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Regulation MED14 F2R 19205424 2007290 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED14 F2R 9141614 428494 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED14 IL1B 11132773 760316 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED14 LBP 12435950 1016091 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED14 TF 2440461 74289 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED14 TLR7 17264163 1733091 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED14 TLR7 18584038 1930985 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED14 TNF 11132773 760315 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED14 TNF 14550746 1152770 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED14 TNF 16945012 1609926 Compound 1 did not affect the or lipopolysaccharide induced [TRAP-luciferase] *response* , suggesting selective inhibition of the RANKL induced pathway . Regulation MED14 TNF 17307735 1719132 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED14 TNF 17988550 1821550 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED14 TNF 18768838 1957096 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED15 ALOX5 1701029 144973 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED15 CD14 12435950 1016068 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED15 EPHB2 19755425 2158615 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Regulation MED15 F2R 19205424 2007279 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED15 F2R 9141614 428483 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED15 IL1B 11132773 760294 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED15 LBP 12435950 1016069 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED15 TF 2440461 74275 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED15 TLR7 17264163 1733080 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED15 TLR7 18584038 1930875 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED15 TNF 11132773 760293 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED15 TNF 14550746 1152756 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED15 TNF 17307735 1719118 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED15 TNF 17988550 1821536 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED15 TNF 18768838 1957085 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED16 ALOX5 1701029 144975 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED16 CD14 12435950 1016072 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED16 F2R 19205424 2007281 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED16 F2R 9141614 428485 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED16 IL1B 11132773 760298 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED16 LBP 12435950 1016073 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED16 TF 2440461 74278 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED16 TLR7 17264163 1733082 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED16 TLR7 18584038 1930895 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED16 TNF 11132773 760297 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED16 TNF 14550746 1152759 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED16 TNF 16945012 1609923 Compound 1 did not affect the or lipopolysaccharide induced [TRAP-luciferase] *response* , suggesting selective inhibition of the RANKL induced pathway . Regulation MED16 TNF 17307735 1719121 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED16 TNF 17988550 1821539 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED16 TNF 18768838 1957087 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED17 ALOX5 1701029 144986 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED17 CD14 12435950 1016094 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED17 EPHB2 19755425 2158631 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Regulation MED17 F2R 19205424 2007292 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED17 F2R 9141614 428496 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED17 IL1B 11132773 760320 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED17 LBP 12435950 1016095 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED17 TF 2440461 74291 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED17 TLR7 17264163 1733093 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED17 TLR7 18584038 1931005 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED17 TNF 11132773 760319 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED17 TNF 14550746 1152772 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED17 TNF 16945012 1609927 Compound 1 did not affect the or lipopolysaccharide induced [TRAP-luciferase] *response* , suggesting selective inhibition of the RANKL induced pathway . Regulation MED17 TNF 17307735 1719134 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED17 TNF 17988550 1821552 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED17 TNF 18768838 1957098 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED18 ALOX5 1701029 144991 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED18 CD14 12435950 1016104 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED18 F2R 19205424 2007297 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED18 F2R 9141614 428501 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED18 IL1B 11132773 760330 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED18 LBP 12435950 1016105 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED18 TF 2440461 74298 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED18 TLR7 17264163 1733098 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED18 TLR7 18584038 1931055 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED18 TNF 11132773 760329 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED18 TNF 14550746 1152779 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED18 TNF 17307735 1719141 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED18 TNF 17988550 1821559 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED18 TNF 18768838 1957103 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED19 ALOX5 1701029 144994 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED19 CD14 12435950 1016110 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED19 F2R 19205424 2007300 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED19 F2R 9141614 428504 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED19 IL1B 11132773 760336 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED19 LBP 12435950 1016111 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED19 TF 2440461 74301 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED19 TLR7 17264163 1733101 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED19 TLR7 18584038 1931085 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED19 TNF 11132773 760335 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED19 TNF 14550746 1152782 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED19 TNF 17307735 1719144 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED19 TNF 17988550 1821562 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED19 TNF 18768838 1957106 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED20 ALOX5 1701029 144974 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED20 CD14 12435950 1016070 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED20 F2R 19205424 2007280 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED20 F2R 9141614 428484 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED20 IL1B 11132773 760296 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED20 LBP 12435950 1016071 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED20 TF 2440461 74277 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED20 TLR7 17264163 1733081 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED20 TLR7 18584038 1930885 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED20 TNF 11132773 760295 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED20 TNF 14550746 1152758 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED20 TNF 17307735 1719120 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED20 TNF 17988550 1821538 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED20 TNF 18768838 1957086 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED21 ALOX5 1701029 144971 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED21 CD14 12435950 1016064 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED21 F2R 19205424 2007277 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED21 F2R 9141614 428481 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED21 IL1B 11132773 760290 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED21 LBP 12435950 1016065 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED21 TF 2440461 74272 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED21 TLR7 17264163 1733078 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED21 TLR7 18584038 1930855 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED21 TNF 11132773 760289 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED21 TNF 14550746 1152753 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED21 TNF 17307735 1719115 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED21 TNF 17988550 1821533 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED21 TNF 18768838 1957083 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED22 ALOX5 1701029 144972 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED22 CD14 12435950 1016066 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED22 F2R 19205424 2007278 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED22 F2R 9141614 428482 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED22 IL1B 11132773 760292 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED22 LBP 12435950 1016067 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED22 TF 2440461 74273 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED22 TLR7 17264163 1733079 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED22 TLR7 18584038 1930865 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED22 TNF 11132773 760291 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED22 TNF 14550746 1152754 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED22 TNF 17307735 1719116 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED22 TNF 17988550 1821534 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED22 TNF 18768838 1957084 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED23 ALOX5 1701029 144985 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED23 CD14 12435950 1016092 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED23 EPHB2 19755425 2158629 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Regulation MED23 F2R 19205424 2007291 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED23 F2R 9141614 428495 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED23 IL1B 11132773 760318 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED23 LBP 12435950 1016093 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED23 TF 2440461 74290 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED23 TLR7 17264163 1733092 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED23 TLR7 18584038 1930995 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED23 TNF 11132773 760317 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED23 TNF 14550746 1152771 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED23 TNF 17307735 1719133 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED23 TNF 17988550 1821551 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED23 TNF 18768838 1957097 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED24 ALOX5 1701029 144981 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED24 CD14 12435950 1016084 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED24 EPHB2 19755425 2158625 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Regulation MED24 F2R 19205424 2007287 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED24 F2R 9141614 428491 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED24 IL1B 11132773 760310 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED24 LBP 12435950 1016085 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED24 TF 2440461 74286 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED24 TLR7 17264163 1733088 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED24 TLR7 18584038 1930955 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED24 TNF 11132773 760309 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED24 TNF 14550746 1152767 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED24 TNF 16945012 1609924 Compound 1 did not affect the or lipopolysaccharide induced [TRAP-luciferase] *response* , suggesting selective inhibition of the RANKL induced pathway . Regulation MED24 TNF 17307735 1719129 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED24 TNF 17988550 1821547 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED24 TNF 18768838 1957093 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED25 ALOX5 1701029 144993 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED25 CD14 12435950 1016108 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED25 EPHB2 19755425 2158637 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Regulation MED25 F2R 19205424 2007299 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED25 F2R 9141614 428503 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED25 IL1B 11132773 760334 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED25 LBP 12435950 1016109 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED25 TF 2440461 74300 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED25 TLR7 17264163 1733100 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED25 TLR7 18584038 1931075 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED25 TNF 11132773 760333 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED25 TNF 14550746 1152781 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED25 TNF 17307735 1719143 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED25 TNF 17988550 1821561 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED25 TNF 18768838 1957105 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED26 ALOX5 1701029 144987 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED26 CD14 12435950 1016096 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED26 EPHB2 19755425 2158633 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Regulation MED26 F2R 19205424 2007293 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED26 F2R 9141614 428497 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED26 IL1B 11132773 760322 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED26 LBP 12435950 1016097 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED26 TF 2440461 74292 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED26 TLR7 17264163 1733094 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED26 TLR7 18584038 1931015 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED26 TNF 11132773 760321 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED26 TNF 14550746 1152773 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED26 TNF 17307735 1719135 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED26 TNF 17988550 1821553 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED26 TNF 18768838 1957099 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED27 ALOX5 1701029 144988 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED27 CD14 12435950 1016098 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED27 F2R 19205424 2007294 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED27 F2R 9141614 428498 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED27 IL1B 11132773 760324 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED27 LBP 12435950 1016099 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED27 TF 2440461 74293 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED27 TLR7 17264163 1733095 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED27 TLR7 18584038 1931025 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED27 TNF 11132773 760323 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED27 TNF 14550746 1152774 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED27 TNF 17307735 1719136 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED27 TNF 17988550 1821554 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED27 TNF 18768838 1957100 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED28 TF 2440461 74296 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED28 TNF 14550746 1152777 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED28 TNF 17307735 1719139 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED28 TNF 17988550 1821557 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED29 ALOX5 1701029 144983 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED29 CD14 12435950 1016088 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED29 F2R 19205424 2007289 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED29 F2R 9141614 428493 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED29 IL1B 11132773 760314 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED29 LBP 12435950 1016089 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED29 TF 2440461 74288 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED29 TLR7 17264163 1733090 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED29 TLR7 18584038 1930975 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED29 TNF 11132773 760313 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED29 TNF 14550746 1152769 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED29 TNF 17307735 1719131 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED29 TNF 17988550 1821549 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED29 TNF 18768838 1957095 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED30 ALOX5 1701029 144982 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED30 CD14 12435950 1016086 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED30 F2R 19205424 2007288 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED30 F2R 9141614 428492 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED30 IL1B 11132773 760312 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED30 LBP 12435950 1016087 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED30 TF 2440461 74287 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED30 TLR7 17264163 1733089 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED30 TLR7 18584038 1930965 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED30 TNF 11132773 760311 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED30 TNF 14550746 1152768 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED30 TNF 17307735 1719130 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED30 TNF 17988550 1821548 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED30 TNF 18768838 1957094 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED31 ALOX5 1701029 144990 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED31 CD14 12435950 1016102 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED31 F2R 19205424 2007296 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED31 F2R 9141614 428500 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED31 IL1B 11132773 760328 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED31 LBP 12435950 1016103 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED31 TF 2440461 74295 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED31 TLR7 17264163 1733097 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED31 TLR7 18584038 1931045 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED31 TNF 11132773 760327 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED31 TNF 14550746 1152776 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED31 TNF 17307735 1719138 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED31 TNF 17988550 1821556 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED31 TNF 18768838 1957102 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED4 ALOX5 1701029 144976 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED4 CD14 12435950 1016074 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED4 EPHB2 19755425 2158617 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Regulation MED4 F2R 19205424 2007282 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED4 F2R 9141614 428486 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED4 IL1B 11132773 760300 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED4 LBP 12435950 1016075 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED4 TF 2440461 74280 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED4 TLR7 17264163 1733083 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED4 TLR7 18584038 1930905 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED4 TNF 11132773 760299 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED4 TNF 14550746 1152761 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED4 TNF 17307735 1719123 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED4 TNF 17988550 1821541 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED4 TNF 18768838 1957088 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED6 ALOX5 1701029 144977 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED6 CD14 12435950 1016076 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED6 EPHB2 19755425 2158619 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Regulation MED6 F2R 19205424 2007283 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED6 F2R 9141614 428487 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED6 IL1B 11132773 760302 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED6 LBP 12435950 1016077 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED6 TF 2440461 74282 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED6 TLR7 17264163 1733084 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED6 TLR7 18584038 1930915 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED6 TNF 11132773 760301 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED6 TNF 14550746 1152763 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED6 TNF 17307735 1719125 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED6 TNF 17988550 1821543 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED6 TNF 18768838 1957089 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED7 ALOX5 1701029 144989 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED7 CD14 12435950 1016100 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED7 EPHB2 19755425 2158635 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Regulation MED7 F2R 19205424 2007295 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED7 F2R 9141614 428499 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED7 IL1B 11132773 760326 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED7 LBP 12435950 1016101 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED7 TF 2440461 74294 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED7 TLR7 17264163 1733096 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED7 TLR7 18584038 1931035 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED7 TNF 11132773 760325 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED7 TNF 14550746 1152775 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED7 TNF 17307735 1719137 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED7 TNF 17988550 1821555 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED7 TNF 18768838 1957101 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED8 ALOX5 1701029 144978 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation MED8 CD14 12435950 1016078 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED8 EPHB2 19755425 2158621 These results support a dominant *role* for signaling in control of translational initiation and [Arc] synthesis during LTP consolidation in the dentate gyrus . Regulation MED8 F2R 19205424 2007284 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation MED8 F2R 9141614 428488 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation MED8 IL1B 11132773 760304 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED8 LBP 12435950 1016079 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation MED8 TF 2440461 74283 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED8 TLR7 17264163 1733085 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation MED8 TLR7 18584038 1930925 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation MED8 TNF 11132773 760303 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation MED8 TNF 14550746 1152764 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED8 TNF 17307735 1719126 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED8 TNF 17988550 1821544 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MED8 TNF 18768838 1957090 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation MED9 TF 2440461 74297 Biological *effect* of on mast cell [mediator] release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron . Regulation MED9 TNF 14550746 1152778 Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the *role* of in pro- and anti-inflammatory [mediator] production and liver injury induced by acetaminophen . Regulation MED9 TNF 17307735 1719140 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of [mediator] , coactivator , and corepressor proteins and Sp1 transcription factor in *response* to all-trans-RA and . Regulation MED9 TNF 17988550 1821558 The aim of this study is to illustrate the roles of adenovirus E1A protein on the inflammation [mediator] expression in *response* to lipopolysaccharide and in rat alveolar epithelial cells . Regulation MEFV TNF 14514692 1164965 As shown by a series of transcription and gel shift assays performed with wild-type and mutated promoter sequences , these two transcription factors act differently on the *dependent* transcription of [MEFV] : C/EBPbeta is the key regulatory factor required to confer cell responsiveness to TNFalpha , whereas NFkappaB p65 increases this response by means of a synergistic interaction with C/EBPbeta that is dependent on the integrity of the identified -55 C/EBP binding site . Regulation MEFV TNF 22736074 2719269 The *role* of and PAI-1 gene polymorphisms in familial [Mediterranean fever] . Regulation MET TNF 19530226 2109520 Previously , we showed that [Met] gene expression is *regulated* by . Regulation METAP2 CAPN8 1706637 147802 Our results suggest that is partially *involved* in the degradation of [MAP2] , and that the use of calpain inhibitors can be a useful clinical approach to cerebral ischemia . Regulation METAP2 HES2 16916793 1602586 Electrophoretic mobility shift analysis , promoter mutagenesis and co-transfection experiments showed that NeuroD , a pro-neuronal differentiation factor , and ( HES1 ) , a transcription repressor , are *involved* in the regulation of [MAP2] promoter activity . Regulation MFI2 JUN 8836133 386149 The *involvement* of the in the regulation of [melanotransferrin (MTf)] gene expression was investigated . Regulation MFN2 TNF 16123358 1449356 Based on the presence of mitochondrial dysfunction in insulin-resistant conditions , we have examined whether Mfn2 expression is dysregulated in skeletal muscle from obese or nonobese type 2 diabetic subjects , whether muscle [Mfn2] expression is *regulated* by body weight loss , and the potential regulatory role of or interleukin-6 . Regulation MFN2 TNF 16123358 1449358 In vitro experiments revealed an inhibitory *effect* of or interleukin-6 on [Mfn2] expression in cultured cells . Regulation MGP TNF 15219845 1264472 The *effects* of ox-LDL , but not , on [MGP] and BMP2 expression were inhibited by pretreatment of cells with an antibody directed at LOX-1 , a lectin-like receptor for ox-LDL ( 10 microg/mL ) . Regulation MIA SMN2 22925727 2678361 CLX and *regulated* the [MIA-up] regulated IL-1ß at mRNA level . Regulation MIA TNFSF10 16525669 1531636 Inhibitory *effects* of on [MIA-PaCa-2] were synergistically augmented by the addition of Phx-1 and Phx-3 , but not by Phx-2 . Regulation MIF EPHB2 15840582 1418289 Our studies reveal that recombinant [MIF] induces cyclin D1 expression in a Rho- , Rho kinase- , MLC kinase- , and *dependent* manner in asynchronous NIH 3T3 fibroblasts . Regulation MIF TNF 15037585 1224044 In addition , the *effects* of interleukin (IL)-1 , , and transforming growth factor (TGF)-beta1 on the induction of [MIF] by conjunctival fibroblasts were studied by quantitative real-time PCR . Regulation MIF TNF 16210389 1507850 Results from enzyme linked immunosorbent assay ( ELISA ) demonstrated a significant dose- and time dependent increase in [MIF] secretion by human endometrial cells in *response* to ( 0.1-100 ng/ml ) . Regulation MIF TNF 9085256 421497 In addition , *regulates* systemic [MIF] production . Regulation MIF TNF 9538268 497741 *regulates* the gene expression of [macrophage migration inhibitory factor] through tyrosine kinase dependent pathway in 3T3-L1 adipocytes . Regulation MIF TNF 9538268 497742 Since adipocytes are regarded as a potential source of various biologically active substances , we examined in more detail the *effect* of on [MIF] expression in 3T3-L1 adipocytes in the present study . Regulation MIP AKT1 24009857 2836994 These results indicate that nystatin is able to activate multiple cellular kinases and , among them , and JNK *play* primary roles in nystatin induced expression of [MIP-1] proteins . Regulation MIP AKT2 24009857 2836995 These results indicate that nystatin is able to activate multiple cellular kinases and , among them , and JNK *play* primary roles in nystatin induced expression of [MIP-1] proteins . Regulation MIP AKT3 24009857 2836996 These results indicate that nystatin is able to activate multiple cellular kinases and , among them , and JNK *play* primary roles in nystatin induced expression of [MIP-1] proteins . Regulation MIP EPHB2 12821152 1104166 These results suggest that activation of is *involved* in the production of [MIP-2] on coculturing of macrophages with late apoptotic cells . Regulation MIP FGF2 15145928 1267563 Specific inhibitors , UO126 for ERK1/2 and SP600125 for JNK , abrogated [Mip] expression in *response* to in the explants . Regulation MIP IL1B 16055671 1466211 Both differentiated and dedifferentiated type II cells secreted [MIP-2] , MCP-1 , and CINC-2 in *response* to a cytokine mixture of IL-1beta , TNF-alpha , and IFN-gamma or to alone . Regulation MIP MPO 22728595 2616782 Our results demonstrate that *regulates* the production of [MIP-2] , which may modulate neutrophil accumulation during lung inflammation . Regulation MIP PITX3 21698120 2446721 Therefore , our data suggest that is *involved* in direct regulation of [MIP/AQP0] expression and that the alteration of MIP/AQP0 expression is likely to contribute to the lens phenotype in cataract patients with PITX3 mutations . Regulation MIP SP3 9421492 481202 Supershift experiments with lens nuclear extracts indicated that Sp3 is also able to interact with this regulatory element , suggesting that Sp1 and may be *involved* in regulation of transcription of the [MIP] gene in the lens . Regulation MIP TLR4 12091428 960149 These findings demonstrate that endotoxin induced keratitis is regulated by *dependent* expression of PECAM-1 and [MIP-2] , which are essential for recruitment of neutrophils to this site and for development of endotoxin induced stromal disease . Regulation MIP WNK1 22187158 2585855 Among an array of NF-?B-responsive genes , Tat mostly activated the [MIP-1a] expression in a *dependent* manner , and bound to the MIP-1a NF-?B enhancer thus promoting the recruitment of p65 with displacement of I?B-a ; Regulation MIPEP EPHB2 12821152 1104164 We then examined whether or not activation is *involved* in the production of [MIP-2] by employing selective inhibitors for MAP kinase kinase 1/2 , PD98059 , and U0126 . Regulation MIPEP IL1B 11259370 795859 Further characterization of MIP-2 regulation by Northern blot analysis confirmed an NO- and *dependent* increase in [MIP-2] mRNA levels . Regulation MIPEP IL1B 12562381 1053782 The aim of the present study was to investigate the *effects* of and Escherichia coli on the expression and secretion of [MIP-2] , the mouse equivalent to human IL-8 , MCP-1 and RANTES in the kidneys of mice with acute pyelonephritis . Regulation MIPEP IL1B 14746807 1182111 We examined the *role* of , a multifunctional cytokine , in regulating the expression of [macrophage inflammatory protein (MIP)-1beta] in human hepatocytes ( Huh7 and HepG2 ) . Regulation MIPEP IL1B 16239643 1508323 Both cell phenotypes secreted [MIP-2] and MCP-1 in *response* to or lipopolysaccharide , but there was no priming or synergy with ozone . Regulation MIPEP TNF 10799303 691105 Moreover , it was observed that dexamethasone treatment inhibited endothelial cell expression of [MIP-2] in *response* to stimulation and markedly reduced the number of adherent neutrophils . Regulation MIPEP TNF 10991927 732889 Notably , 2 h pretreatment with dexamethasone ( 10 mg kg ( -1 ) , i.p. ) reduced [MIP-2] expression by 65 % in *response* to ( 0.1 microg ml(-1) ) . Regulation MIPEP TNF 17510837 1745425 Here , DPI significantly reduced the and MIP-2 responses to quartz , and the [MIP-2] *response* to SPM . Regulation MIPEP TNF 20338560 2333740 A direct stimulatory *effect* of on [MIP-1B] , GRO-a , and IL-15 messenger RNA ( mRNA ) expression was demonstrated . Regulation MIR10B CTGF 22020939 2516631 Cysteine-rich <61-connective tissue growth factor-nephroblastoma> overexpressed 5 ( CCN5 ) /Wnt-1 induced signaling protein-2 ( WISP-2 ) *regulates* [microRNA-10b] via hypoxia-inducible factor-1a-TWIST signaling networks in human breast cancer cells . Regulation MIR145 CTGF 23390502 2739730 [MicroRNA-145] is downregulated in glial tumors and *regulates* glioma cell migration by targeting . Regulation MIR146A TNF 23592910 2773275 Differential *regulation* of [microRNA-146a] and microRNA-146b-5p in human retinal pigment epithelial cells by interleukin-1ß , , and interferon-? . Regulation MIR146B TNF 23592910 2773303 Differential *regulation* of microRNA-146a and [microRNA-146b-5p] in human retinal pigment epithelial cells by interleukin-1ß , , and interferon-? . Regulation MIR21 EPHB2 23473787 2766455 [MiR-21] *involve* in mediated upregulation of MMP9 in the rat hippocampus following cerebral ischemia . Regulation MITF GPR115 20487197 2263448 In particular , we analysed the *involvement* of the in sphingosylphosphorylcholine induced [MITF] degradation . Regulation MITF GPR132 20487197 2263437 In particular , we analysed the *involvement* of the in sphingosylphosphorylcholine induced [MITF] degradation . Regulation MITF GPR87 20487197 2263517 In particular , we analysed the *involvement* of the in sphingosylphosphorylcholine induced [MITF] degradation . Regulation MKL1 EPHB2 15292266 1303139 Taken together these results demonstrate that S1P activates multiple signaling pathways in SMC and regulates proliferation by *dependent* activation of Elk-1 and differentiation by RhoA dependent activation of [MRTF-A] . Regulation MLS TP63 16224147 1469402 To obtain new insights into the *role* of in [malignant lymphomas (MLs)] , immunohistochemical staining for p63 and p53 was performed in 126 cases of MLs . Regulation MLST8 CCND1 19225536 2054554 As [mTOR signaling] is activated in MCL and may *control* levels , we show that p53 activation may downregulate the AKT/mTOR pathway through a mechanism involving AMP kinase (AMPK) . Regulation MLST8 MAP2K6 21659537 2459572 Previous work indicated that [mTORC1] activation by the phorbol ester PMA ( phorbol 12-myristate 13-acetate ) depends upon PKCs and may *involve* . Regulation MLXIPL FOXA1 20534694 2295593 [ChREBP] expression is directly *controlled* by and Foxa2 in both the fetal endocrine pancreas as well as mature islets . Regulation MME MAP2K6 10036247 591986 Inhibition of cAMP dependent kinase , or CaM kinase II does not *affect* [NEP55] or L68 phosphorylation . Regulation MME TNF 1658014 169010 Although the data provide evidence for the role of kinases in the *effect* of on binding of tumor cells to [MME] , this role appears to be a complex one . Regulation MMP1 CD14 19320896 2052456 In this study , the cell transdifferentiation of circulating ( + ) monocytes into KLCs and their regulatory *effect* on [matrix metalloproteinase-1 (MMP-1)] expression in dermal fibroblasts were evaluated . Regulation MMP1 CD14 19320896 2052457 Our findings show the potential transdifferentiation of circulating ( + ) monocytes into KLCs and their regulatory *effect* on [MMP-1] expression in dermal fibroblasts . Regulation MMP1 ENTPD8 23941770 2861794 The ATP mediated MMP-1 inhibition was restored in the presence of POM-1 , a specific ENTPD inhibitor , suggesting that was *involved* in the [MMP-1] inhibition . Regulation MMP1 EPHB2 14634122 1170906 Exposure of FLSCs to nonselective COX and selective COX-2 inhibitors in the absence of stimulation resulted in up-regulation of [MMP-1] expression in an *dependent* manner . Regulation MMP1 EPHB2 15610507 1348297 Taken together , our results suggest that and JNK *play* an important role in the induction of [MMP-1] and MMP-3 by heat shock and that the heat shock induced expression of MMP-1 and MMP-3 is mediated via an IL-6 dependent autocrine mechanism . Regulation MMP1 EPHB2 15640153 1381321 [MMP-1] secretion was regulated by E prostaglandins ( PGEs ) in an *dependent* manner . Regulation MMP1 EPHB2 21165206 2356695 Furthermore , the inhibition of ERK or JNK with specific chemical inhibitors prevented MßCD induced MMP-1 expression , which indicates that and JNK *play* an important role in cholesterol depletion mediated [MMP-1] induction . Regulation MMP1 EPHB2 21757573 2515920 *Involvement* of JNK-AP-1 and signaling in tension stimulated expression of type I collagen and [MMP-1] in human periodontal ligament fibroblasts . Regulation MMP1 HBEGF 17656145 1793674 [MMP-1] *responses* to histamine and were further tested by the use of H2 receptor antagonist , EGFR inhibitor and mitogen activator protein kinase (MAPK) inhibitor . Regulation MMP1 IL1B 10616215 575835 and ( d ) test whether the *effect* of on the [MMP] mRNA expression could be detected with in situ hybridization . Regulation MMP1 IL1B 12789230 1097347 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing , IL-4 , and TNF-alpha expression . Regulation MMP1 IL1B 14996278 1216215 We investigated the mechanism of MMP-1 expression in human gingival fibroblasts in *response* to the stimulation with , and the role of inducible-type cyclooxygenase-2 (COX-2) and prostaglandin E2 ( PGE2 ) in the regulation of [MMP-1] expression . Regulation MMP1 IL1B 16380175 1494052 [MMP-1] synthesis in the resident cells of arthritic joints is *regulated* via two major cytokines , and TNF-alpha . Regulation MMP1 IL1B 16468044 1573935 Role of mitogen activated protein kinases and NFkappaB on induced *effects* on collagen type II , [MMP-1] and 13 mRNA expression in normal articular human chondrocytes . Regulation MMP1 IL1B 17097317 1709072 MMP-1 gene expression was mirrored by increases in NF-kappaB gene expression , and inhibition of NF-kappaB nuclear translocation with dominant negative IkappaBalpha reduced *dependent* [MMP-1] gene expression . Regulation MMP1 IL1B 17940116 1849325 Our objective was to evaluate : 1 ) MMP-1 and MMP-3 expression in decidual sections from uncomplicated term , idiopathic preterm , and CAM complicated deliveries , and 2 ) the separate and interactive *effects* of , TNF-alpha , medroxyprogesterone acetate ( MPA ) , and a p38 MAPK inhibitor ( SB203580 ) on [MMP-1] and MMP-3 expression in term decidual cells (DCs) . Regulation MMP1 IL1B 18060744 1846774 is *involved* in the up-regulation of UVA induced [MMP-1] in dermal fibroblasts , and IL-1beta and MIF cytokine network induce MMP-1 and contribute to the loss of interstitial collagen in skin photoaging . Regulation MMP1 IL1B 19107653 2018809 Inhibition of histone deacetylases antagonized FGF2 and *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP1 IL1B 21344389 2480425 We found that the MEK inhibitor U0126 and the RSK inhibitor BI-D1870 both reduced *dependent* [MMP-1] gene expression in SW1353 cells . Regulation MMP1 IL1B 21344389 2480458 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Regulation MMP1 IL1B 8906257 394134 Type I collagen gene expression , and abrogated the *effect* of on [MMP] expression . Regulation MMP1 IL1B 8978456 403540 *Regulation* of rat [interstitial collagenase] gene expression in growth cartilage and chondrocytes by vitamin D3 , , and okadaic acid . Regulation MMP1 IL1B 9257189 448430 Cell-type specific *regulation* of human [interstitial collagenase-1] gene expression by in human fibroblasts and BC-8701 breast cancer cells . Regulation MMP1 IL1B 9257189 448432 We conclude that both the transcriptional and post-transcriptional *regulation* of [MMP-1] gene expression by is controlled by cell-type specific mechanisms , and we suggest that IL-1 induced MMP-1 expression in tumor cells and in neighboring stromal cells may amplify the invasive ability of tumor cells . Regulation MMP1 IL1B 9269785 450130 Whereas [MMP-1] is positively *regulated* by , tumor necrosis factor-alpha , and Oncostatin M , MMP-2 is not modulated by any of these cytokines . Regulation MMP1 IL1B 9328843 457407 *Regulation* of the rat [interstitial collagenase] promoter by , c-Jun , and Ras dependent signaling in growth plate chondrocytes . Regulation MMP1 IL6R 12146533 969824 The *role* of soluble in mediating the effects of IL-6 on [matrix metalloproteinase-1] and tissue inhibitor of metalloproteinase-1 expression by gingival fibroblasts . Regulation MMP1 MAP2K6 19833163 2196251 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP1 OLFM4 23161172 2707567 For further insight into the mechanisms underlying OLFM4 mediated suppression of tumor progression , we examined the *effect* of on the expression of integrin and [matrix metalloproteinase (MMP)] , both of which are involved in tumor progression . Regulation MMP1 PLAT 23565108 2767698 Reactive oxygen species can enhance the *effects* of on [MMP] activation through the loss of caveolin-1 (cav-1) , a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability . Regulation MMP1 PLAU 12117412 997475 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Regulation MMP1 SPHK1 16278291 1502526 In this study , we investigated the *role* of in the regulation of expression of [matrix metalloproteinase 1 (MMP1)] in dermal fibroblasts , a key event in regulation of extra cellular matrix . Regulation MMP1 SPHK1 16278291 1502533 Additional data revealed a specific role of dhS1P , and not S1P , as a mediator of *dependent* activation of ERK1/2 and up-regulation of [MMP1] . Regulation MMP1 TFPI2 10082661 599115 Collectively , our results suggest that indirectly *regulates* [MMP-1-] and MMP-3 catalyzed matrix proteolysis by regulating the activation of proMMP-1 and proMMP-3 . Regulation MMP1 TFPI2 12787920 1097089 These data provide presumptive evidence that does not bind to MMP-2 , MMP-9 and MMP-1 , or *regulate* [MMP-1] , in the extracellular matrix . Regulation MMP1 TNF 10329260 613090 Neither nor transforming growth factor-beta , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP1 TNF 11450703 836648 Furthermore , the inhibitors completely prevented the *dependent* induction of [MMP-1] , MMP-3 , ICAM-1 , and COX-2 mRNAs . Regulation MMP1 TNF 11747375 889264 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , and interleukin (IL)-1beta on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP1 TNF 12010565 941227 Of these enzymes , the expression of [MMP-1] and MMP-13 is substantially increased in *response* to IL-1 and , and elevated levels of these collagenases are observed in arthritic tissues . Regulation MMP1 TNF 12113550 963837 This study used reverse transcriptase-PCR to investigate the *effects* of on [matrix metalloproteinase (MMP)] mRNA expression in human periodontal ligament fibroblasts . Regulation MMP1 TNF 12789230 1097344 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and expression . Regulation MMP1 TNF 15146414 1247775 The *effects* of stimulation with lipopolysaccharide (LPS) and on the production of [MMP-1] were assessed accordingly . Regulation MMP1 TNF 15663564 1350392 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Regulation MMP1 TNF 16012040 1431585 The objective of this study was to investigate the *effects* of IL-6 , soluble IL-6 receptor ( sIL-6R ) , HGF , and IL-8 on [MMP-1] , -2 and -9 expression by two oral squamous cell carcinoma cell lines ( UT-SCC-20A and -24A ) . Regulation MMP1 TNF 16106101 1445012 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Regulation MMP1 TNF 16905636 1672844 [MMP] production is largely *dependent* , further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke induced lung disease . Regulation MMP1 TNF 17031853 1683039 In *response* to , [MMP-1] is induced and actively released from HCS-2/8 cells . Regulation MMP1 TNF 17031853 1683077 Taken together , these findings indicate that Raf-1/MEK/ERK signaling pathway plays a crucial role in the production of [MMP-1] in HCS-2/8 cells in *response* to , and that the produced PGE ( 2 ) downregulates the expression of MMP-1 by blockage of TNF-alpha induced Raf-1 activation through EP4-PGE ( 2 ) receptor activation . Regulation MMP1 TNF 17940116 1849322 Our objective was to evaluate : 1 ) MMP-1 and MMP-3 expression in decidual sections from uncomplicated term , idiopathic preterm , and CAM complicated deliveries , and 2 ) the separate and interactive *effects* of IL-1beta , , medroxyprogesterone acetate ( MPA ) , and a p38 MAPK inhibitor ( SB203580 ) on [MMP-1] and MMP-3 expression in term decidual cells (DCs) . Regulation MMP1 TNF 18277865 1872189 The *effect* of on membrane type [(MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MMP1 TNF 19055644 1999854 Mutation in a putative nuclear factor (NF)-kappaB binding site at -2541 bp almost completely abolished the TNF-alpha response to MMP-1 gene-promoter activity , suggesting transcriptional *regulation* of [MMP-1] expression by via this site . Regulation MMP1 TNF 19281093 2007638 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Regulation MMP1 TNF 19778432 2163664 increased matrix metalloproteinase (MMP)-3 and a disintegrin and metalloproteinase with thrombospondin motifs ( ADAMTS)-4 mRNA expression , whereas collagen type I was decreased , and aggrecan , collagen type II as well as [MMP-1] , -2 , -13 and ADAMTS-5 were variably *affected* . Regulation MMP1 TNF 23417988 2843437 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP1 TNF 24062615 2846676 We have demonstrated that budesonide concentration-dependently ( 10 ( -10 ) -10 ( -7 ) M ) inhibited IL-6 , IL-8 , [MMP-1] , and MMP-3 release by HFL-1 cells in *response* to IL-1ß plus . Regulation MMP10 EPHB2 22142512 2536343 In conclusion , we demonstrated that CRP promoted MMP-10 expression and activity in cardiomyocytes , and clarified that c-Raf/MEK/ERK and signaling pathways were *involved* in [MMP-10] expression regulation via activation of DNA binding sites for AP-1 and STAT3 in cardiomyocytes . Regulation MMP10 IL1B 10616215 575836 and ( d ) test whether the *effect* of on the [MMP] mRNA expression could be detected with in situ hybridization . Regulation MMP10 IL1B 12789230 1097352 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing , IL-4 , and TNF-alpha expression . Regulation MMP10 IL1B 19107653 2018811 Inhibition of histone deacetylases antagonized FGF2 and *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP10 IL1B 21344389 2480459 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Regulation MMP10 IL1B 8906257 394135 Type I collagen gene expression , and abrogated the *effect* of on [MMP] expression . Regulation MMP10 MAP2K6 19833163 2196258 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP10 MAP2K6 22142512 2536350 In conclusion , we demonstrated that CRP promoted MMP-10 expression and activity in cardiomyocytes , and clarified that and JAK1/ERK signaling pathways were *involved* in [MMP-10] expression regulation via activation of DNA binding sites for AP-1 and STAT3 in cardiomyocytes . Regulation MMP10 OLFM4 23161172 2707568 For further insight into the mechanisms underlying OLFM4 mediated suppression of tumor progression , we examined the *effect* of on the expression of integrin and [matrix metalloproteinase (MMP)] , both of which are involved in tumor progression . Regulation MMP10 PLAT 23565108 2767699 Reactive oxygen species can enhance the *effects* of on [MMP] activation through the loss of caveolin-1 (cav-1) , a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability . Regulation MMP10 PLAU 12117412 997476 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Regulation MMP10 TNF 10329260 613094 Neither nor transforming growth factor-beta , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP10 TNF 11747375 889266 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , and interleukin (IL)-1beta on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP10 TNF 12113550 963838 This study used reverse transcriptase-PCR to investigate the *effects* of on [matrix metalloproteinase (MMP)] mRNA expression in human periodontal ligament fibroblasts . Regulation MMP10 TNF 12789230 1097349 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and expression . Regulation MMP10 TNF 15663564 1350393 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Regulation MMP10 TNF 16106101 1445013 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Regulation MMP10 TNF 16905636 1672845 [MMP] production is largely *dependent* , further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke induced lung disease . Regulation MMP10 TNF 18277865 1872190 The *effect* of on membrane type [(MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MMP10 TNF 19281093 2007639 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Regulation MMP10 TNF 23417988 2843440 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP11 IL1B 10616215 575837 and ( d ) test whether the *effect* of on the [MMP] mRNA expression could be detected with in situ hybridization . Regulation MMP11 IL1B 12789230 1097357 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing , IL-4 , and TNF-alpha expression . Regulation MMP11 IL1B 19107653 2018813 Inhibition of histone deacetylases antagonized FGF2 and *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP11 IL1B 21344389 2480460 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Regulation MMP11 IL1B 8906257 394136 Type I collagen gene expression , and abrogated the *effect* of on [MMP] expression . Regulation MMP11 MAP2K6 19833163 2196265 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP11 OLFM4 23161172 2707569 For further insight into the mechanisms underlying OLFM4 mediated suppression of tumor progression , we examined the *effect* of on the expression of integrin and [matrix metalloproteinase (MMP)] , both of which are involved in tumor progression . Regulation MMP11 PLAT 23565108 2767700 Reactive oxygen species can enhance the *effects* of on [MMP] activation through the loss of caveolin-1 (cav-1) , a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability . Regulation MMP11 PLAU 12117412 997477 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Regulation MMP11 TNF 10329260 613098 Neither nor transforming growth factor-beta , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP11 TNF 11747375 889268 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , and interleukin (IL)-1beta on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP11 TNF 12113550 963839 This study used reverse transcriptase-PCR to investigate the *effects* of on [matrix metalloproteinase (MMP)] mRNA expression in human periodontal ligament fibroblasts . Regulation MMP11 TNF 12789230 1097354 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and expression . Regulation MMP11 TNF 15663564 1350394 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Regulation MMP11 TNF 16106101 1445014 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Regulation MMP11 TNF 16905636 1672846 [MMP] production is largely *dependent* , further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke induced lung disease . Regulation MMP11 TNF 18277865 1872191 The *effect* of on membrane type [(MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MMP11 TNF 19281093 2007640 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Regulation MMP11 TNF 23417988 2843443 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP12 FUT4 22799384 2628628 In this study we determined the *effect* of on expression of [matrix metalloproteinase (MMP)-12] induced by EGF in A431 cells . Regulation MMP12 IL1B 10616215 575838 and ( d ) test whether the *effect* of on the [MMP] mRNA expression could be detected with in situ hybridization . Regulation MMP12 IL1B 12789230 1097362 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing , IL-4 , and TNF-alpha expression . Regulation MMP12 IL1B 19107653 2018815 Inhibition of histone deacetylases antagonized FGF2 and *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP12 IL1B 21344389 2480461 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Regulation MMP12 IL1B 8906257 394137 Type I collagen gene expression , and abrogated the *effect* of on [MMP] expression . Regulation MMP12 MAP2K6 19833163 2196272 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP12 OLFM4 23161172 2707570 For further insight into the mechanisms underlying OLFM4 mediated suppression of tumor progression , we examined the *effect* of on the expression of integrin and [matrix metalloproteinase (MMP)] , both of which are involved in tumor progression . Regulation MMP12 PLAT 23565108 2767701 Reactive oxygen species can enhance the *effects* of on [MMP] activation through the loss of caveolin-1 (cav-1) , a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability . Regulation MMP12 PLAU 12117412 997478 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Regulation MMP12 TNF 10329260 613102 Neither nor transforming growth factor-beta , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP12 TNF 11747375 889270 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , and interleukin (IL)-1beta on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP12 TNF 12113550 963840 This study used reverse transcriptase-PCR to investigate the *effects* of on [matrix metalloproteinase (MMP)] mRNA expression in human periodontal ligament fibroblasts . Regulation MMP12 TNF 12789230 1097359 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and expression . Regulation MMP12 TNF 15663564 1350395 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Regulation MMP12 TNF 16106101 1445015 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Regulation MMP12 TNF 16905636 1672847 [MMP] production is largely *dependent* , further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke induced lung disease . Regulation MMP12 TNF 18277865 1872192 The *effect* of on membrane type [(MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MMP12 TNF 19281093 2007641 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Regulation MMP12 TNF 20051654 2200941 In the present study , we investigated the *effect* of on the expressions of [MMP-12] in airway epithelial cells , one of the sources of MMP-12 in the airway , and its underlying mechanism . Regulation MMP12 TNF 23417988 2843446 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP13 CTGF 21914781 2497171 *Effect* of on FGF2 induced proliferation and MMP9 and [MMP13] productions by chondrocytes . Regulation MMP13 CTGF 21914781 2497173 Next , we examined the combinational *effects* of and FGF2 on the proliferation of and [matrix metalloproteinase (MMP)-9 and -13] productions by cultured chondrocytes . Regulation MMP13 EPHB2 18487224 1944911 CXCL12 seems to enhance LHSCC cell invasion through paracrine activated CXCR4 , which triggers *dependent* [MMP-13] upregulation . Regulation MMP13 EPHB2 21679050 2562296 However , transfection with a dominant negative form of the Ras protein ( Ras ( N17 ) ) inhibited the ERK activation and MMP-9 and -13 mRNA expressions induced by IL-1ß , which supported the *involvement* of signalling in IL-1ß induced [MMP-9 and -13] expressions . Regulation MMP13 IL1B 10616215 575839 and ( d ) test whether the *effect* of on the [MMP] mRNA expression could be detected with in situ hybridization . Regulation MMP13 IL1B 12789230 1097367 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing , IL-4 , and TNF-alpha expression . Regulation MMP13 IL1B 17971297 1826696 Here , we investigated the role of Lef1 in mediated [MMP13] *regulation* in mouse chondrocytes . Regulation MMP13 IL1B 19035520 1998622 S100A8 significantly increased the *effect* of on MMP-3 , [MMP-13] , and ADAMTS-5 . Regulation MMP13 IL1B 19107653 2018817 Inhibition of histone deacetylases antagonized FGF2 and *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP13 IL1B 20633667 2310418 Inhibition of both p38alpha and p38gamma with BIRB796 resulted in less inhibition of [MMP-13] production in *response* to or FN-f than did inhibition of only p38alpha with SB203580 . Regulation MMP13 IL1B 21344389 2480462 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Regulation MMP13 IL1B 8906257 394138 Type I collagen gene expression , and abrogated the *effect* of on [MMP] expression . Regulation MMP13 IL1B 9324020 456597 To examine , by immunohistochemistry , the localization and distribution of human collagenase-3 in normal , osteoarthritis ( OA ) , and rheumatoid arthritis ( RA ) cartilage , and to investigate the *effects* of and transforming growth factor beta ( TGFbeta ) on the synthesis and distribution of [collagenase-3] . Regulation MMP13 MAP2K6 19833163 2196279 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP13 MAP2K6 21075784 2389632 PKC , FAK , and JNK are *involved* in collagen stimulated expression of [MMP-13] . Regulation MMP13 OLFM4 23161172 2707571 For further insight into the mechanisms underlying OLFM4 mediated suppression of tumor progression , we examined the *effect* of on the expression of integrin and [matrix metalloproteinase (MMP)] , both of which are involved in tumor progression . Regulation MMP13 PLAT 23565108 2767702 Reactive oxygen species can enhance the *effects* of on [MMP] activation through the loss of caveolin-1 (cav-1) , a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability . Regulation MMP13 PLAU 12117412 997479 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Regulation MMP13 PLAU 21913037 2674578 In conclusion , MMP-9 and might be *involved* in the activation of [pro-MMP-13] through unknown mechanisms in arthritic diseases . Regulation MMP13 TCN1 23368947 2853724 This study examines the inhibitory *effects* of on lipopolysaccharide- , parathyroid hormone (PTH)- , and prostaglandin E2 ( PGE2 ) -induced expression of [MMP-13] in UMR 106-01 cells , an osteoblastic osteosarcoma cell line . Regulation MMP13 TCN1 23368947 2853728 MMP-13 promoter reporter assay was used to explore possible direct *effects* of on the [MMP-13] promoter . Regulation MMP13 TNF 10329260 613106 Neither nor transforming growth factor-beta , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP13 TNF 11747375 889272 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , and interleukin (IL)-1beta on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP13 TNF 12010565 941229 Of these enzymes , the expression of MMP-1 and [MMP-13] is substantially increased in *response* to IL-1 and , and elevated levels of these collagenases are observed in arthritic tissues . Regulation MMP13 TNF 12113550 963841 This study used reverse transcriptase-PCR to investigate the *effects* of on [matrix metalloproteinase (MMP)] mRNA expression in human periodontal ligament fibroblasts . Regulation MMP13 TNF 12789230 1097364 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and expression . Regulation MMP13 TNF 15663564 1350396 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Regulation MMP13 TNF 16106101 1445016 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Regulation MMP13 TNF 16905636 1672848 [MMP] production is largely *dependent* , further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke induced lung disease . Regulation MMP13 TNF 18277865 1872193 The *effect* of on membrane type [(MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MMP13 TNF 19281093 2007642 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Regulation MMP13 TNF 21211511 2391905 These results provide strong pharmacological and genetic evidence for the implication of H-Ras and NADPH oxidase generated superoxide production in [MMP-13] gene *regulation* by IL-1ß and . Regulation MMP13 TNF 23417988 2843449 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP14 CAPN8 22002053 2513194 S1P and WSS synergistically activated [MT1-MMP] and induced cell membrane localization of MT1-MMP in a *dependent* manner . Regulation MMP14 EPHB2 14871836 1208299 Expression of a constitutively active form of MEK1 promoted MMP-2 processing concomitant with the increase of MT1-MMP levels , suggesting that [MT1-MMP] is *regulated* by signaling . Regulation MMP14 EPHB2 16234249 1489459 Overexpression of deltaCAPRI or a constitutive active form of Ras up-regulated the expression level of matrix-metalloproteinase 14 (MMP14) , which directly cleaves the ectodomain of RANKL , whereas activation by expressing the constitutive active Mek1 did not *affect* the [MMP14] expression or RANKL shedding . Regulation MMP14 IL1B 10616215 575840 and ( d ) test whether the *effect* of on the [MMP] mRNA expression could be detected with in situ hybridization . Regulation MMP14 IL1B 11678909 873737 In this study , we examined the *effects* of , one of the inflammatory cytokines , on the expression of [MT1-MMP] and the activation of pro-MMP-2 using rheumatoid synovial cells . Regulation MMP14 IL1B 12789230 1097372 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing , IL-4 , and TNF-alpha expression . Regulation MMP14 IL1B 19107653 2018819 Inhibition of histone deacetylases antagonized FGF2 and *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP14 IL1B 21344389 2480463 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Regulation MMP14 IL1B 8906257 394139 Type I collagen gene expression , and abrogated the *effect* of on [MMP] expression . Regulation MMP14 MAP2K6 14871836 1208305 Expression of a constitutively active form of MEK1 promoted MMP-2 processing concomitant with the increase of MT1-MMP levels , suggesting that [MT1-MMP] is *regulated* by signaling . Regulation MMP14 MAP2K6 19833163 2196286 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP14 OLFM4 23161172 2707572 For further insight into the mechanisms underlying OLFM4 mediated suppression of tumor progression , we examined the *effect* of on the expression of integrin and [matrix metalloproteinase (MMP)] , both of which are involved in tumor progression . Regulation MMP14 PLAT 23565108 2767703 Reactive oxygen species can enhance the *effects* of on [MMP] activation through the loss of caveolin-1 (cav-1) , a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability . Regulation MMP14 PLAU 12117412 997480 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Regulation MMP14 TNF 10329260 613110 Neither nor transforming growth factor-beta , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP14 TNF 10996723 733900 We have investigated the *effects* of and interferon ( INF-gamma ) , the potent Bacillus Calmette-Guerin ( BCG ) -induced cytokines on the production of MMP-2 , MMP-9 , TIMP-1 , TIMP-2 and [MT1-MMP] in high grade human bladder cancer cell lines , T-24 , J-82 and HT-1376 cell lines . Regulation MMP14 TNF 11747375 889274 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , and interleukin (IL)-1beta on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP14 TNF 12113550 963842 This study used reverse transcriptase-PCR to investigate the *effects* of on [matrix metalloproteinase (MMP)] mRNA expression in human periodontal ligament fibroblasts . Regulation MMP14 TNF 12789230 1097369 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and expression . Regulation MMP14 TNF 15663564 1350397 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Regulation MMP14 TNF 16106101 1445017 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Regulation MMP14 TNF 16905636 1672849 [MMP] production is largely *dependent* , further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke induced lung disease . Regulation MMP14 TNF 18277865 1872194 The *effect* of on membrane type [(MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MMP14 TNF 19281093 2007643 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Regulation MMP14 TNF 23266860 2741453 Induction of [MT1-MMP] expression in *response* to occurs via activation of nuclear factor ( NF ) -?B on inhibitory ?B kinase ( IKK ) activation and subsequently phosphorylation/degradation of I?B-a . Regulation MMP14 TNF 23417988 2843452 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP14 TNF 24213464 2714795 Because tumor necrosis factor (TNF)-a is known to be elevated in AML , we also investigated the *effect* of on [MT1-MMP] expression . Regulation MMP15 IL1B 10616215 575841 and ( d ) test whether the *effect* of on the [MMP] mRNA expression could be detected with in situ hybridization . Regulation MMP15 IL1B 12789230 1097377 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing , IL-4 , and TNF-alpha expression . Regulation MMP15 IL1B 19107653 2018821 Inhibition of histone deacetylases antagonized FGF2 and *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP15 IL1B 21344389 2480464 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Regulation MMP15 IL1B 8906257 394140 Type I collagen gene expression , and abrogated the *effect* of on [MMP] expression . Regulation MMP15 MAP2K6 19833163 2196293 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP15 OLFM4 23161172 2707573 For further insight into the mechanisms underlying OLFM4 mediated suppression of tumor progression , we examined the *effect* of on the expression of integrin and [matrix metalloproteinase (MMP)] , both of which are involved in tumor progression . Regulation MMP15 PLAT 23565108 2767704 Reactive oxygen species can enhance the *effects* of on [MMP] activation through the loss of caveolin-1 (cav-1) , a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability . Regulation MMP15 PLAU 12117412 997481 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Regulation MMP15 TNF 10329260 613114 Neither nor transforming growth factor-beta , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP15 TNF 11747375 889276 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , and interleukin (IL)-1beta on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP15 TNF 12113550 963843 This study used reverse transcriptase-PCR to investigate the *effects* of on [matrix metalloproteinase (MMP)] mRNA expression in human periodontal ligament fibroblasts . Regulation MMP15 TNF 12789230 1097374 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and expression . Regulation MMP15 TNF 15663564 1350398 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Regulation MMP15 TNF 16106101 1445018 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Regulation MMP15 TNF 16905636 1672850 [MMP] production is largely *dependent* , further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke induced lung disease . Regulation MMP15 TNF 18093301 1839999 As an example a novel *effect* of on [matrix metalloproteinase 15] in HLA-G positive ACH-3P and explants was found . Regulation MMP15 TNF 18277865 1872195 The *effect* of on membrane type [(MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MMP15 TNF 19281093 2007644 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Regulation MMP15 TNF 23417988 2843455 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP16 IL1B 10616215 575842 and ( d ) test whether the *effect* of on the [MMP] mRNA expression could be detected with in situ hybridization . Regulation MMP16 IL1B 12789230 1097382 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing , IL-4 , and TNF-alpha expression . Regulation MMP16 IL1B 19107653 2018823 Inhibition of histone deacetylases antagonized FGF2 and *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP16 IL1B 21344389 2480465 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Regulation MMP16 IL1B 8906257 394141 Type I collagen gene expression , and abrogated the *effect* of on [MMP] expression . Regulation MMP16 MAP2K6 19833163 2196300 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP16 OLFM4 23161172 2707574 For further insight into the mechanisms underlying OLFM4 mediated suppression of tumor progression , we examined the *effect* of on the expression of integrin and [matrix metalloproteinase (MMP)] , both of which are involved in tumor progression . Regulation MMP16 PLAT 23565108 2767705 Reactive oxygen species can enhance the *effects* of on [MMP] activation through the loss of caveolin-1 (cav-1) , a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability . Regulation MMP16 PLAU 12117412 997482 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Regulation MMP16 TNF 10329260 613118 Neither nor transforming growth factor-beta , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP16 TNF 11747375 889278 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , and interleukin (IL)-1beta on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP16 TNF 12113550 963844 This study used reverse transcriptase-PCR to investigate the *effects* of on [matrix metalloproteinase (MMP)] mRNA expression in human periodontal ligament fibroblasts . Regulation MMP16 TNF 12789230 1097379 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and expression . Regulation MMP16 TNF 15663564 1350399 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Regulation MMP16 TNF 16106101 1445019 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Regulation MMP16 TNF 16905636 1672851 [MMP] production is largely *dependent* , further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke induced lung disease . Regulation MMP16 TNF 18277865 1872196 The *effect* of on membrane type [(MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MMP16 TNF 19281093 2007645 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Regulation MMP16 TNF 23417988 2843458 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP17 IL1B 10616215 575843 and ( d ) test whether the *effect* of on the [MMP] mRNA expression could be detected with in situ hybridization . Regulation MMP17 IL1B 12789230 1097387 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing , IL-4 , and TNF-alpha expression . Regulation MMP17 IL1B 19107653 2018825 Inhibition of histone deacetylases antagonized FGF2 and *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP17 IL1B 21344389 2480466 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Regulation MMP17 IL1B 8906257 394142 Type I collagen gene expression , and abrogated the *effect* of on [MMP] expression . Regulation MMP17 MAP2K6 19833163 2196307 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP17 OLFM4 23161172 2707575 For further insight into the mechanisms underlying OLFM4 mediated suppression of tumor progression , we examined the *effect* of on the expression of integrin and [matrix metalloproteinase (MMP)] , both of which are involved in tumor progression . Regulation MMP17 PLAT 23565108 2767706 Reactive oxygen species can enhance the *effects* of on [MMP] activation through the loss of caveolin-1 (cav-1) , a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability . Regulation MMP17 PLAU 12117412 997483 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Regulation MMP17 TNF 10329260 613122 Neither nor transforming growth factor-beta , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP17 TNF 11747375 889280 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , and interleukin (IL)-1beta on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP17 TNF 12113550 963845 This study used reverse transcriptase-PCR to investigate the *effects* of on [matrix metalloproteinase (MMP)] mRNA expression in human periodontal ligament fibroblasts . Regulation MMP17 TNF 12789230 1097384 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and expression . Regulation MMP17 TNF 15663564 1350400 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Regulation MMP17 TNF 16106101 1445020 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Regulation MMP17 TNF 16905636 1672852 [MMP] production is largely *dependent* , further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke induced lung disease . Regulation MMP17 TNF 18277865 1872197 The *effect* of on membrane type [(MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MMP17 TNF 19281093 2007646 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Regulation MMP17 TNF 23417988 2843461 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP19 IL1B 10616215 575844 and ( d ) test whether the *effect* of on the [MMP] mRNA expression could be detected with in situ hybridization . Regulation MMP19 IL1B 12789230 1097392 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing , IL-4 , and TNF-alpha expression . Regulation MMP19 IL1B 19107653 2018827 Inhibition of histone deacetylases antagonized FGF2 and *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP19 IL1B 21344389 2480467 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Regulation MMP19 IL1B 8906257 394143 Type I collagen gene expression , and abrogated the *effect* of on [MMP] expression . Regulation MMP19 MAP2K6 19833163 2196314 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP19 OLFM4 23161172 2707576 For further insight into the mechanisms underlying OLFM4 mediated suppression of tumor progression , we examined the *effect* of on the expression of integrin and [matrix metalloproteinase (MMP)] , both of which are involved in tumor progression . Regulation MMP19 PLAT 23565108 2767707 Reactive oxygen species can enhance the *effects* of on [MMP] activation through the loss of caveolin-1 (cav-1) , a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability . Regulation MMP19 PLAU 12117412 997484 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Regulation MMP19 TNF 10329260 613126 Neither nor transforming growth factor-beta , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP19 TNF 11747375 889282 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , and interleukin (IL)-1beta on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP19 TNF 12113550 963846 This study used reverse transcriptase-PCR to investigate the *effects* of on [matrix metalloproteinase (MMP)] mRNA expression in human periodontal ligament fibroblasts . Regulation MMP19 TNF 12789230 1097389 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and expression . Regulation MMP19 TNF 15663564 1350401 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Regulation MMP19 TNF 16106101 1445021 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Regulation MMP19 TNF 16905636 1672853 [MMP] production is largely *dependent* , further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke induced lung disease . Regulation MMP19 TNF 18277865 1872198 The *effect* of on membrane type [(MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MMP19 TNF 19281093 2007647 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Regulation MMP19 TNF 23417988 2843464 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP2 ALOX5 19586628 2194860 Thus , this study investigated the *role* of <5-LO> in HNE enhanced [MMP-2] production in VSMC , and the mechanisms by which this enzyme could be activated by HNE . Regulation MMP2 CTGF 19301817 2056141 The proliferation signal mediated by high glucose was demonstrated via CTGF/RAGE , while [MMP-2] was *regulated* by but not RAGE . Regulation MMP2 EDN2 11249854 793603 We examined the *effects* of on the activity of [matrix metalloproteinase-2 (MMP-2)] in cultured MCs . Regulation MMP2 EPHB2 15492268 1321511 These results suggest that PGE ( 2 ) mediates pancreatic cancer cellular invasiveness through an *dependent* induction of [MMP-2] expression and activity . Regulation MMP2 EPHB2 15492828 1321619 Using chemical inhibitors and dominant negative mutants of MAPKs , we provide evidence that while both p38 MAPK and ERKs are required for TGF-beta induced MCF10A cell migration and invasion , TGF-beta induced [MMP-2] and MMP-9 expression depends on p38 MAPK signaling , but is *independent* of activity . Regulation MMP2 IL1B 10616215 575845 and ( d ) test whether the *effect* of on the [MMP] mRNA expression could be detected with in situ hybridization . Regulation MMP2 IL1B 11678909 873738 In this study , we examined the *effects* of , one of the inflammatory cytokines , on the expression of MT1-MMP and the activation of [pro-MMP-2] using rheumatoid synovial cells . Regulation MMP2 IL1B 12371906 1034771 Culture of rat cardiac fibroblasts for 24 h in 1 % oxygen enhanced MMP-2 synthesis by more than 5-fold and augmented the [MMP-2] synthetic *responses* of these cells to endothelin-1 , angiotensin II and . Regulation MMP2 IL1B 12789230 1097397 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing , IL-4 , and TNF-alpha expression . Regulation MMP2 IL1B 16290189 1532340 However , [MMP-2] , -11 , -14 , and TIMPs were not *affected* by either or tensile strain . Regulation MMP2 IL1B 16911716 1601757 Neither nor TNF-alpha treatment *affected* [MMP-2] protein secretion . Regulation MMP2 IL1B 16987994 1692464 RT-PCR and Western blot analyses confirmed increased expression of [MMP-2] in *response* to . Regulation MMP2 IL1B 19107653 2018829 Inhibition of histone deacetylases antagonized FGF2 and *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP2 IL1B 19602123 2149830 The aims of this study were to investigate the *effect* of on the expression of MMP-1 , [MMP-2] and extracellular MMP inducer in human periodontal ligament cells and to evaluate whether the regulation of MMP-1 and MMP-2 by this cytokine occurred through an effect on extracellular MMP inducer expression . Regulation MMP2 IL1B 19671357 2119497 To investigate the *effect* of on expression and activity of [matrix metalloproteinase-2 (MMP-2)] of cultured human cardiac fibroblasts and related signaling pathway . Regulation MMP2 IL1B 21344389 2480468 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Regulation MMP2 IL1B 8906257 394144 Type I collagen gene expression , and abrogated the *effect* of on [MMP] expression . Regulation MMP2 IL1B 9727371 529932 The present study examines the *effect* of transforming growth factor-beta1 ( TGF-beta1 ) and on the regulation of [gelatinase A] , gelatinase B , tissue inhibitor of metalloproteinase-I ( TIMP-I ) and TIMP-II in human glomerular epithelial cells ( GEC ) . Regulation MMP2 MAP2K6 10623478 658083 Taken together , these results strongly suggest that kinase signaling , but not PI3 kinase signaling , *plays* a critical role in the activation of [MMP-2] secretion and , subsequently , in the invasiveness of v-src transformed cells . Regulation MMP2 MAP2K6 19833163 2196321 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP2 MMP28 10553104 565575 We demonstrate that a soluble constitutively produced by myeloma cells was *responsible* for [pro-MMP-2] activation . Regulation MMP2 MMP28 11172680 784155 gelatinase A ) activity has been correlated to cancer invasiveness , and membrane type ( MT1-MMP ) expressed by tumor cells is *involved* in localizing and activating [pro-MMP-2] , a pathway believed to mediate cancer induced tissue breakdown . Regulation MMP2 MMP28 11415441 829087 These results indicate that in HUVECs the activation of [pro-MMP-2] by thrombin *involves* increased activity and preferential cleavage of the MT-MMP processed 64 kDa MMP-2 form in the presence of cells . Regulation MMP2 MMP28 11858950 914715 To study the *role* of in the activation of [MMP-2] , skin specimens of DF ( five cases ) and MFH ( three cases ) were immunohistochemically studied using in situ zymography and the antibodies against matrix metalloproteinase-2 (MMP-2) and membrane type 1-3-MMPs (MT1-3-MMPs) . Regulation MMP2 MMP28 14514237 1146884 In this study , we evaluated the cytotoxicity of hydroxamic acid based inhibitors ( ONO-4817 , ONO-MI1-514 , and ONO-MI1-570 ) , and their inhibitory *effects* on [MMP-2] and -9 activities and growth of Porphyromonas gingivalis . Regulation MMP2 MMP7 10553104 565590 We demonstrate that a soluble constitutively produced by myeloma cells was *responsible* for [pro-MMP-2] activation . Regulation MMP2 MMP7 11172680 784170 gelatinase A ) activity has been correlated to cancer invasiveness , and membrane type ( MT1-MMP ) expressed by tumor cells is *involved* in localizing and activating [pro-MMP-2] , a pathway believed to mediate cancer induced tissue breakdown . Regulation MMP2 MMP7 11415441 829102 These results indicate that in HUVECs the activation of [pro-MMP-2] by thrombin *involves* increased activity and preferential cleavage of the MT-MMP processed 64 kDa MMP-2 form in the presence of cells . Regulation MMP2 MMP7 11858950 914730 To study the *role* of in the activation of [MMP-2] , skin specimens of DF ( five cases ) and MFH ( three cases ) were immunohistochemically studied using in situ zymography and the antibodies against matrix metalloproteinase-2 (MMP-2) and membrane type 1-3-MMPs (MT1-3-MMPs) . Regulation MMP2 MMP7 14514237 1146899 In this study , we evaluated the cytotoxicity of hydroxamic acid based inhibitors ( ONO-4817 , ONO-MI1-514 , and ONO-MI1-570 ) , and their inhibitory *effects* on [MMP-2] and -9 activities and growth of Porphyromonas gingivalis . Regulation MMP2 OLFM4 23161172 2707577 For further insight into the mechanisms underlying OLFM4 mediated suppression of tumor progression , we examined the *effect* of on the expression of integrin and [matrix metalloproteinase (MMP)] , both of which are involved in tumor progression . Regulation MMP2 PLAT 23565108 2767708 Reactive oxygen species can enhance the *effects* of on [MMP] activation through the loss of caveolin-1 (cav-1) , a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability . Regulation MMP2 PLAU 10615432 575804 Epithelioid SMC , but not swirling SMC , secreted [MMP-2] in *response* to and tPA . Regulation MMP2 PLAU 12117412 997485 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Regulation MMP2 TGM2 19324884 2080305 *regulates* [matrix metalloproteinase-2] in ovarian cancer by modulating cAMP-response element binding protein activity . Regulation MMP2 TNF 10329260 613130 Neither nor transforming growth factor-beta , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP2 TNF 10996723 733895 *Effects* of and interferon-gamma on expressions of [matrix metalloproteinase-2] and -9 in human bladder cancer cells . Regulation MMP2 TNF 11194561 761960 The objective of this investigation was to ascertain the regulatory *role* of on [MMP-2] activity relevant to the folliculo-luteal transition in ewes . Regulation MMP2 TNF 11747375 889284 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , and interleukin (IL)-1beta on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP2 TNF 12113550 963847 This study used reverse transcriptase-PCR to investigate the *effects* of on [matrix metalloproteinase (MMP)] mRNA expression in human periodontal ligament fibroblasts . Regulation MMP2 TNF 12524413 1047917 [MMP2] secretion by PSCs was significantly increased by TGF-beta1 and IL-6 , but was not *affected* by . Regulation MMP2 TNF 12789230 1097394 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and expression . Regulation MMP2 TNF 1435512 204809 In unstimulated osteoblast-like MC3T3-E1 cell cultures [72-kDa gelatinase] enzyme activity was much greater than 92-kDa activity and was not substantially *regulated* ( less than 40 % change ) by IL-1 , or PTH . Regulation MMP2 TNF 14998513 1216640 Differential *regulation* of [gelatinase A] and B and TIMP-1 and -2 by and HIV virions in astrocytes . Regulation MMP2 TNF 15090307 1237863 The *effect* of exogenous and anti-TNF-alpha on the expression of [matrix metalloproteinase-2 (MMP-2)] and tissue inhibitor of metalloproteinases-2 ( TIMP-2 ) in human trophoblastic cells was investigated with reverse transcription ( RT ) -PCR ( RT-PCR ) . Regulation MMP2 TNF 15513534 1328330 The addition of FP caused significant suppression of [MMP-2] and -9 production from nasal polyp fibroblasts in *response* to stimulation . Regulation MMP2 TNF 15570615 1355622 [Matrix metalloproteinase-2 (MMP-2)] expression and *regulation* by in the bovine corpus luteum . Regulation MMP2 TNF 15663564 1350402 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Regulation MMP2 TNF 16106101 1445022 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Regulation MMP2 TNF 16106101 1445031 TR at more than 5 x 10 ( -5 ) M inhibited the production of [MMP-2] and MMP-9 from NF in *response* to stimulation , whereas TIMP-1 and TIMP-2 production was scarcely affected . Regulation MMP2 TNF 16905636 1672854 [MMP] production is largely *dependent* , further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke induced lung disease . Regulation MMP2 TNF 17062332 1637241 Fenofibrate significantly inhibited the stimulatory *effect* of on [MMP-2] and MMP-9 activities in HUVECs . Regulation MMP2 TNF 18277865 1872199 The *effect* of on membrane type [(MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MMP2 TNF 19281093 2007648 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Regulation MMP2 TNF 21518085 2423044 Transforming growth factor-ß1 suppresses the up-regulation of [matrix metalloproteinase-2] by lung fibroblasts in *response* to . Regulation MMP2 TNF 21518085 2423048 In this study , we demonstrated that the active MMP-2 secreted by lung fibroblasts reached the peak level at 12 hours after TNF-a treatment , whereas , by adding anti-TGF-ß1 antibody in the culture medium , the [MMP-2] production in *response* to was maintained at high levels after 24 hours of treatment . Regulation MMP2 TNF 22336124 2520797 After down regulating the protein FAK , had no *effect* on the activity of [MMP-2] ( The data of MMP-2 were 55.13 ± 0.66 , 55.67 ± 0.43 , 55.49 ± 0.20 and 55.91 ± 0.37 in groups A , B , C and D , F = 2.73 , P = 0.079 ) . Regulation MMP2 TNF 23417988 2843467 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP2 TNF 8280080 240546 On the other hand , [MMP-2] and TIMP-2 were not affected or were *affected* in a variable way by and/or phorbol ester , suggesting a dissimilar regulation of these proteins . Regulation MMP2 TNF 9130458 426871 This study examined the *role* of IFN-gamma and ( + ) in the regulation of the matrix metalloproteinases , [MMP-2] ( 72 kD gelatinase A ) and MMP-9 ( 92 kD gelatinase B ) . Regulation MMP2 TNF 9545106 498340 We found a lack of [MMP-2] *response* to IL-1 , , and phorbol esters . Regulation MMP20 IL1B 10616215 575846 and ( d ) test whether the *effect* of on the [MMP] mRNA expression could be detected with in situ hybridization . Regulation MMP20 IL1B 12789230 1097402 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing , IL-4 , and TNF-alpha expression . Regulation MMP20 IL1B 19107653 2018831 Inhibition of histone deacetylases antagonized FGF2 and *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP20 IL1B 21344389 2480469 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Regulation MMP20 IL1B 8906257 394145 Type I collagen gene expression , and abrogated the *effect* of on [MMP] expression . Regulation MMP20 MAP2K6 19833163 2196328 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP20 OLFM4 23161172 2707578 For further insight into the mechanisms underlying OLFM4 mediated suppression of tumor progression , we examined the *effect* of on the expression of integrin and [matrix metalloproteinase (MMP)] , both of which are involved in tumor progression . Regulation MMP20 PLAT 23565108 2767709 Reactive oxygen species can enhance the *effects* of on [MMP] activation through the loss of caveolin-1 (cav-1) , a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability . Regulation MMP20 PLAU 12117412 997486 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Regulation MMP20 TNF 10329260 613134 Neither nor transforming growth factor-beta , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP20 TNF 11747375 889286 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , and interleukin (IL)-1beta on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP20 TNF 12113550 963848 This study used reverse transcriptase-PCR to investigate the *effects* of on [matrix metalloproteinase (MMP)] mRNA expression in human periodontal ligament fibroblasts . Regulation MMP20 TNF 12789230 1097399 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and expression . Regulation MMP20 TNF 15663564 1350403 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Regulation MMP20 TNF 16106101 1445023 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Regulation MMP20 TNF 16905636 1672855 [MMP] production is largely *dependent* , further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke induced lung disease . Regulation MMP20 TNF 18277865 1872200 The *effect* of on membrane type [(MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MMP20 TNF 19281093 2007649 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Regulation MMP20 TNF 23417988 2843470 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP21 IL1B 10616215 575833 and ( d ) test whether the *effect* of on the [MMP] mRNA expression could be detected with in situ hybridization . Regulation MMP21 IL1B 12789230 1097337 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing , IL-4 , and TNF-alpha expression . Regulation MMP21 IL1B 19107653 2018805 Inhibition of histone deacetylases antagonized FGF2 and *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP21 IL1B 21344389 2480456 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Regulation MMP21 IL1B 8906257 394132 Type I collagen gene expression , and abrogated the *effect* of on [MMP] expression . Regulation MMP21 MAP2K6 19833163 2196237 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP21 OLFM4 23161172 2707565 For further insight into the mechanisms underlying OLFM4 mediated suppression of tumor progression , we examined the *effect* of on the expression of integrin and [matrix metalloproteinase (MMP)] , both of which are involved in tumor progression . Regulation MMP21 PLAT 23565108 2767696 Reactive oxygen species can enhance the *effects* of on [MMP] activation through the loss of caveolin-1 (cav-1) , a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability . Regulation MMP21 PLAU 12117412 997473 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Regulation MMP21 TNF 10329260 613082 Neither nor transforming growth factor-beta , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP21 TNF 11747375 889260 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , and interleukin (IL)-1beta on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP21 TNF 12113550 963835 This study used reverse transcriptase-PCR to investigate the *effects* of on [matrix metalloproteinase (MMP)] mRNA expression in human periodontal ligament fibroblasts . Regulation MMP21 TNF 12789230 1097334 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and expression . Regulation MMP21 TNF 15663564 1350390 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Regulation MMP21 TNF 16106101 1445010 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Regulation MMP21 TNF 16905636 1672842 [MMP] production is largely *dependent* , further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke induced lung disease . Regulation MMP21 TNF 18277865 1872187 The *effect* of on membrane type [(MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MMP21 TNF 19281093 2007636 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Regulation MMP21 TNF 23417988 2843431 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP24 IL1B 10616215 575847 and ( d ) test whether the *effect* of on the [MMP] mRNA expression could be detected with in situ hybridization . Regulation MMP24 IL1B 12789230 1097407 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing , IL-4 , and TNF-alpha expression . Regulation MMP24 IL1B 19107653 2018833 Inhibition of histone deacetylases antagonized FGF2 and *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP24 IL1B 21344389 2480470 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Regulation MMP24 IL1B 8906257 394146 Type I collagen gene expression , and abrogated the *effect* of on [MMP] expression . Regulation MMP24 MAP2K6 19833163 2196335 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP24 OLFM4 23161172 2707579 For further insight into the mechanisms underlying OLFM4 mediated suppression of tumor progression , we examined the *effect* of on the expression of integrin and [matrix metalloproteinase (MMP)] , both of which are involved in tumor progression . Regulation MMP24 PLAT 23565108 2767710 Reactive oxygen species can enhance the *effects* of on [MMP] activation through the loss of caveolin-1 (cav-1) , a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability . Regulation MMP24 PLAU 12117412 997487 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Regulation MMP24 TNF 10329260 613138 Neither nor transforming growth factor-beta , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP24 TNF 11747375 889288 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , and interleukin (IL)-1beta on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP24 TNF 12113550 963849 This study used reverse transcriptase-PCR to investigate the *effects* of on [matrix metalloproteinase (MMP)] mRNA expression in human periodontal ligament fibroblasts . Regulation MMP24 TNF 12789230 1097404 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and expression . Regulation MMP24 TNF 15663564 1350404 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Regulation MMP24 TNF 16106101 1445024 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Regulation MMP24 TNF 16905636 1672856 [MMP] production is largely *dependent* , further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke induced lung disease . Regulation MMP24 TNF 18277865 1872201 The *effect* of on membrane type [(MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MMP24 TNF 19281093 2007650 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Regulation MMP24 TNF 23417988 2843473 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP25 IL1B 10616215 575830 and ( d ) test whether the *effect* of on the [MMP] mRNA expression could be detected with in situ hybridization . Regulation MMP25 IL1B 12789230 1097322 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing , IL-4 , and TNF-alpha expression . Regulation MMP25 IL1B 19107653 2018799 Inhibition of histone deacetylases antagonized FGF2 and *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP25 IL1B 21344389 2480453 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Regulation MMP25 IL1B 8906257 394129 Type I collagen gene expression , and abrogated the *effect* of on [MMP] expression . Regulation MMP25 MAP2K6 19833163 2196216 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP25 OLFM4 23161172 2707562 For further insight into the mechanisms underlying OLFM4 mediated suppression of tumor progression , we examined the *effect* of on the expression of integrin and [matrix metalloproteinase (MMP)] , both of which are involved in tumor progression . Regulation MMP25 PLAT 23565108 2767693 Reactive oxygen species can enhance the *effects* of on [MMP] activation through the loss of caveolin-1 (cav-1) , a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability . Regulation MMP25 PLAU 12117412 997470 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Regulation MMP25 TNF 10329260 613070 Neither nor transforming growth factor-beta , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP25 TNF 11747375 889254 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , and interleukin (IL)-1beta on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP25 TNF 12113550 963832 This study used reverse transcriptase-PCR to investigate the *effects* of on [matrix metalloproteinase (MMP)] mRNA expression in human periodontal ligament fibroblasts . Regulation MMP25 TNF 12789230 1097319 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and expression . Regulation MMP25 TNF 15663564 1350387 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Regulation MMP25 TNF 16106101 1445007 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Regulation MMP25 TNF 16905636 1672839 [MMP] production is largely *dependent* , further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke induced lung disease . Regulation MMP25 TNF 18277865 1872184 The *effect* of on membrane type [(MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MMP25 TNF 19281093 2007633 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Regulation MMP25 TNF 23417988 2843422 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP26 IL1B 10616215 575831 and ( d ) test whether the *effect* of on the [MMP] mRNA expression could be detected with in situ hybridization . Regulation MMP26 IL1B 12789230 1097327 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing , IL-4 , and TNF-alpha expression . Regulation MMP26 IL1B 19107653 2018801 Inhibition of histone deacetylases antagonized FGF2 and *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP26 IL1B 21344389 2480454 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Regulation MMP26 IL1B 8906257 394130 Type I collagen gene expression , and abrogated the *effect* of on [MMP] expression . Regulation MMP26 MAP2K6 19833163 2196223 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP26 OLFM4 23161172 2707563 For further insight into the mechanisms underlying OLFM4 mediated suppression of tumor progression , we examined the *effect* of on the expression of integrin and [matrix metalloproteinase (MMP)] , both of which are involved in tumor progression . Regulation MMP26 PLAT 23565108 2767694 Reactive oxygen species can enhance the *effects* of on [MMP] activation through the loss of caveolin-1 (cav-1) , a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability . Regulation MMP26 PLAU 12117412 997471 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Regulation MMP26 TNF 10329260 613074 Neither nor transforming growth factor-beta , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP26 TNF 11747375 889256 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , and interleukin (IL)-1beta on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP26 TNF 12113550 963833 This study used reverse transcriptase-PCR to investigate the *effects* of on [matrix metalloproteinase (MMP)] mRNA expression in human periodontal ligament fibroblasts . Regulation MMP26 TNF 12789230 1097324 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and expression . Regulation MMP26 TNF 15663564 1350388 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Regulation MMP26 TNF 16106101 1445008 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Regulation MMP26 TNF 16905636 1672840 [MMP] production is largely *dependent* , further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke induced lung disease . Regulation MMP26 TNF 18277865 1872185 The *effect* of on membrane type [(MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MMP26 TNF 19281093 2007634 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Regulation MMP26 TNF 23417988 2843425 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP27 IL1B 10616215 575832 and ( d ) test whether the *effect* of on the [MMP] mRNA expression could be detected with in situ hybridization . Regulation MMP27 IL1B 12789230 1097332 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing , IL-4 , and TNF-alpha expression . Regulation MMP27 IL1B 19107653 2018803 Inhibition of histone deacetylases antagonized FGF2 and *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP27 IL1B 21344389 2480455 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Regulation MMP27 IL1B 8906257 394131 Type I collagen gene expression , and abrogated the *effect* of on [MMP] expression . Regulation MMP27 MAP2K6 19833163 2196230 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP27 OLFM4 23161172 2707564 For further insight into the mechanisms underlying OLFM4 mediated suppression of tumor progression , we examined the *effect* of on the expression of integrin and [matrix metalloproteinase (MMP)] , both of which are involved in tumor progression . Regulation MMP27 PLAT 23565108 2767695 Reactive oxygen species can enhance the *effects* of on [MMP] activation through the loss of caveolin-1 (cav-1) , a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability . Regulation MMP27 PLAU 12117412 997472 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Regulation MMP27 TNF 10329260 613078 Neither nor transforming growth factor-beta , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP27 TNF 11747375 889258 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , and interleukin (IL)-1beta on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP27 TNF 12113550 963834 This study used reverse transcriptase-PCR to investigate the *effects* of on [matrix metalloproteinase (MMP)] mRNA expression in human periodontal ligament fibroblasts . Regulation MMP27 TNF 12789230 1097329 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and expression . Regulation MMP27 TNF 15663564 1350389 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Regulation MMP27 TNF 16106101 1445009 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Regulation MMP27 TNF 16905636 1672841 [MMP] production is largely *dependent* , further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke induced lung disease . Regulation MMP27 TNF 18277865 1872186 The *effect* of on membrane type [(MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MMP27 TNF 19281093 2007635 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Regulation MMP27 TNF 23417988 2843428 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP28 ACE 17308006 1747475 This study sought to determine whether inhibitors can directly *regulate* [MMP] activity and whether this results in positive structural and functional adaptations to the heart . Regulation MMP28 AKT1 20382513 2287773 However , HG-down regulated MT-1 [MMP] expression was *independent* of activation of ERK1/2 and when using their inhibitors of DB98059 ( ERK1/2 ) and LY294002 ( Akt ) alone or in combination . Regulation MMP28 AKT1 23061721 2703259 *dependent* activation of cAMP responsive element binding protein ( CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing [MMP] activity by doxycycline partially reversed FN accumulation in the InsR silenced cells . Regulation MMP28 AKT2 20382513 2287774 However , HG-down regulated MT-1 [MMP] expression was *independent* of activation of ERK1/2 and when using their inhibitors of DB98059 ( ERK1/2 ) and LY294002 ( Akt ) alone or in combination . Regulation MMP28 AKT2 23061721 2703260 *dependent* activation of cAMP responsive element binding protein ( CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing [MMP] activity by doxycycline partially reversed FN accumulation in the InsR silenced cells . Regulation MMP28 AKT3 20382513 2287775 However , HG-down regulated MT-1 [MMP] expression was *independent* of activation of ERK1/2 and when using their inhibitors of DB98059 ( ERK1/2 ) and LY294002 ( Akt ) alone or in combination . Regulation MMP28 AKT3 23061721 2703261 *dependent* activation of cAMP responsive element binding protein ( CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing [MMP] activity by doxycycline partially reversed FN accumulation in the InsR silenced cells . Regulation MMP28 APAF1 22226830 2550099 Altogether , we have for the first time demonstrated the critical *role* of in the regulation of MAPK , ROS , and [MMP] in UVC radiated MEFs and propose that the amplification feedback loop among mitochondrial signal molecules culminates in the demise of the cell . Regulation MMP28 ATL1 19144404 2071446 Adult T-cell leukemia (ATL) is an aggressive disease characterized by visceral invasion , and *regulates* [matrix metalloproteinase (MMP)] activities of the endothelial cells . Regulation MMP28 ATL2 19144404 2071447 is an aggressive disease characterized by visceral invasion , and ATL *regulates* [matrix metalloproteinase (MMP)] activities of the endothelial cells . Regulation MMP28 ATL3 19144404 2071448 Adult T-cell leukemia (ATL) is an aggressive disease characterized by visceral invasion , and *regulates* [matrix metalloproteinase (MMP)] activities of the endothelial cells . Regulation MMP28 ATP5O 21339745 2420396 We investigated whether the expression and cellular localization of corresponded to the stage of human pancreatic cancer , and its *effect* on [matrix metalloproteinase (MMP)] activation in vitro . Regulation MMP28 BAX 12813466 1103238 The data reported herein indicate that LMP does not suffice to trigger caspase activation and that *dependent* [MMP] is a critical step of LMP induced cell death . Regulation MMP28 BCL2 12085233 958943 This study investigates the *effect* of N-Myc and on [MMP] expression and activation . Regulation MMP28 BCL2 22491967 2613096 Second , we have highlighted that during etoposide or TNF-a treatments , intracellular ROS level , [MMP] and cell death are all *regulated* by caspases and , with caspases acting early in the process . Regulation MMP28 BSG 12553375 1028946 mediated [MMP] *regulation* in tumor and endothelial cells . Regulation MMP28 BSG 12692261 1080487 Our results suggest that during the development of MDR , the expression of is *responsible* for the increased activity of [MMP] in MDR cell lines . Regulation MMP28 BSG 15758150 1417046 This report characterizes the expression pattern of , a putative *regulator* of [MMP] induction , in the rat ovary . Regulation MMP28 BSG 16207318 1464270 The *role* of in [MMP] production and cell invasion in vitro were studied through the co-culture of human CD14+ monocytes or monocytic line THP-1 cells and human fibroblasts , as well as by gel zymography and an invasion assay . Regulation MMP28 BSG 16207318 1464292 Our study demonstrates that the increased expression of on monocytes/macrophages in RA may be *responsible* for elevated [MMP] secretion , cell invasion and CyPA mediated cell migration into the joints , all of which may contribute to the cartilage and bone destruction of RA . Regulation MMP28 BSG 16507143 1574189 The *role* of in [MMP] production and the cells ' invasiveness in vitro were studied by the co-culture of FLS with the human THP-1 cell line or monocytes/macrophages , by gel zymography and by invasion assay . Regulation MMP28 BSG 16507143 1574211 Our studies demonstrated that the overexpression on monocytes/macrophages and FLS in RA patients may be *responsible* for the enhanced [MMP] secretion and activation and for the invasiveness of synoviocytes . Regulation MMP28 BSG 17825230 1795446 To further investigate the *effect* of on neutrophil on [MMP] production by FLS and the invasive potential of FLS in RA , antagonist peptide against EMMPRIN/CD147 ( AP-9 ) was added to the coculture . Regulation MMP28 BSG 17869266 1843048 Therefore , we tested the hypothesis that expression *regulates* [matrix metalloproteinase (MMP)] activity in rat ventricular myocytes in vitro . Regulation MMP28 BSG 17869266 1843092 To determine whether expression *regulates* [matrix metalloproteinase (MMP)] activity , EMMPRIN activity was inhibited by adenoviral expression of an inhibitory mutant of EMMPRIN . Regulation MMP28 BSG 18751374 1956314 Thus *regulates* migration , [MMP] production by SCC cells and deposition of the TN-C matrix . Regulation MMP28 BSG 19003972 2016267 We have analysed the *role* of in the induction of [MMP] genes during mammary gland differentiation and involution . Regulation MMP28 BSG 19003972 2016355 In summary the data argue against a causal *role* for for the induction of [MMP] gene expression during adult mammary gland development . Regulation MMP28 BSG 20369361 2238556 The current results indicate that could thus be *involved* in the early stage of tooth germ development and morphogenesis , possibly by regulating the expression of [MMP] genes . Regulation MMP28 CA1 23192945 2751999 This suggested that both ROS and ( 2+ ) signaling *play* roles in the increased [MMP] via Ca?(i) ( 2+ ) -dependent and/or -independent mechanisms , since ?? ( m ) elevation was reversed by NAC and BAPTA . Regulation MMP28 CA2 24739681 2936324 The results reveal an intericate relationship between homeostasis , the ATP generation ability of cells , SO and ROS production , and *regulation* of [MMP] following infection by bovine adenovirus 3 . Regulation MMP28 CA2 9685651 522131 Of the three major gelatinases found in rat mammary gland at different stages of ontogeny , 60K gelatinase , a *dependent* neutral [MMP] , seems to be involved in involution , as it appears at the late stage of involution . Regulation MMP28 CALCA 16549372 1582296 These results are the first evidence of calcitonin receptor expression on articular chondrocytes and that the chondroprotective *effects* of might involve the inhibition of [MMP] expression . Regulation MMP28 CARM1 18511550 1951924 Furthermore , we show that also *regulates* [MMP] expression at the post-transcriptional level , either positively or negatively . Regulation MMP28 CCR9 15623660 1349141 These studies suggest that the expression and activation of *affect* cancer cell migration , invasion , and [MMP] expression , which together may affect prostate cancer metastasis . Regulation MMP28 CD40 17949416 1894439 Finally , we investigated whether ligand (CD40L) interactions were *involved* in T-cell stimulated [MMP] secretion from macrophages . Regulation MMP28 CDC73 23911909 2840424 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Regulation MMP28 CDH11 22127696 2514849 The objective of this study was to determine if synovial fibroblast [MMP] production is *regulated* by . Regulation MMP28 CDH11 22127696 2514961 These results underscore the existence of a pathway by which *regulates* [MMP] production and has important implications for joint destruction in RA . Regulation MMP28 CPOX 21371008 2453198 [MMP] up-regulation may be a *target* for and prostaglandin ( PG ) receptor inhibition , but the extent and mechanisms of COX independent MMP up-regulation are unclear . Regulation MMP28 CRP 16580524 1543648 We examined the *effect* of on [matrix metalloproteinase (MMP)] and inhibitor expression in endothelial cells and in patients with clinical and subclinical atherosclerosis . Regulation MMP28 CTNNB1 15313922 1285775 Because can *regulate* [MMP] expression , we investigated the expression of several MMPs and TIMPs in aggressive fibromatosis tumors that develop in Apc+/Apc1638N mice . Regulation MMP28 CTR9 23911909 2840425 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Regulation MMP28 CXCL12 17197427 1724659 Moreover , the inflammatory cytokines TGF-beta1 , IL-1beta , and TNF-alpha up-regulated MMP-2 , MT1-MMP , and/or MMP-9 production in these cells , resulting in a strong stimulation of chemotactic migration through ECM , whereas the chemokine exhibited minor *effects* on [MMP/TIMP] expression and cell invasion . Regulation MMP28 CXCL12 21357602 2415700 *effects* of on [MMP] production by human endometrial cells . Regulation MMP28 CXCL12 21357602 2415722 The aim of this study was to investigate CXCL12 and CXCR4 expression in human endometrium and to see if could *affect* [matrix metalloproteinase (MMP)] production by endometrial stromal and epithelial cells . Regulation MMP28 ECM1 15844197 1418371 The experimental observations suggest that [MMP] activity *regulates* the coordination of early heart organogenesis by affecting ventral closure of the heart and gut tubes , asymmetric cell proliferation in the dorsal mesocardium to drive looping direction , and degradation within the dorsal mesocardium allowing looping to proceed toward completion . Regulation MMP28 ECM2 15844197 1418372 The experimental observations suggest that [MMP] activity *regulates* the coordination of early heart organogenesis by affecting ventral closure of the heart and gut tubes , asymmetric cell proliferation in the dorsal mesocardium to drive looping direction , and degradation within the dorsal mesocardium allowing looping to proceed toward completion . Regulation MMP28 EDN1 12842810 1149573 However , little is known about *regulation* of vascular [MMP] activity in hypertension . Regulation MMP28 EDN1 12842810 1149617 Thus early changes in mediated *regulation* of [MMP] activity were measured in borderline hypertensive rats that develop impaired vasorelaxation and hypertension with chronic exposure to stress . Regulation MMP28 EDN1 14558091 1153701 Recently , it was suggested that , a potent vasoconstrictor , may be *involved* in [MMP] regulation . Regulation MMP28 EDN1 16417466 1554144 In the present study , we have investigated the *effect* of ( i ) ET-1 ( ) and its precursor , big ET-1 , on [MMP] ( matrix metalloproteinase)-2 and MMP-9 synthesis and activity in osteosarcoma tissue , and ( ii ) ET-1 receptor antagonists on cell invasion . Regulation MMP28 EDN1 16503991 1541663 However , the *effect* of Type 2 diabetes and/or on the regulation of ECM and [MMP] gene expression in different vascular beds remains unknown . Regulation MMP28 EDN1 20725136 2306891 We have previously shown that type 2 diabetes promotes remodeling of middle cerebral arteries ( MCA ) characterized by increased media/lumen ( M/L ) ratio and [MMP] activity in an *dependent* manner in the Goto-Kakizaki ( GK ) rat model . Regulation MMP28 EDNRA 12842810 1149551 Recent studies demonstrated that receptors *regulate* cardiac [MMP] activity and fibrosis in DOCA-salt hypertension . Regulation MMP28 EEF1A2 19946014 2240968 Because statins interfere with Rho activation , we investigated the *effect* on COX-2 and [MMP] expressions in the human endothelium . Regulation MMP28 EGFR 23614740 2774816 Reactive oxygen species ( ROS ) and activation *play* central roles in UV-induced [MMP] expression through initiating extracellular signal regulated kinase ( ERK ) -mediated AP-1 signalling . Regulation MMP28 ESR1 12915398 1157528 We examined and compared and progesterone receptor (PR) expression and the *effects* of 17beta-estradiol ( E2 ) and progesterone ( P ) on collagen synthesis and [matrix metalloproteinase (MMP)] activities in the aortic arch and in cultured aortic smooth muscle cells ( ASMC ) of atherosclerosis-susceptible ( C57Bl6/J , B6 ) or -resistant ( C3H/HeJ , C3H ) mice . Regulation MMP28 ETV4 10836994 698084 We have previously reported that the Ets-oncogene family transcription factor positively *regulates* transcription of [MMP] genes in transient expression assays and that overexpression of the E1AF gene confers an invasive phenotype on breast cancer cells . Regulation MMP28 FABP5 20040021 2258524 Transwell Matrigel invasion assay , MTS cell proliferation assay , reverse transcription-polymerase chain reaction , Western blot , and gelatin zymography analysis were used to investigate the *effects* of on cell invasion , growth , and [matrix metalloproteinase (MMP)] production . Regulation MMP28 FGF2 19107653 2018806 Inhibition of histone deacetylases antagonized and IL-1beta *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP28 FLT1 9776730 540207 These data suggest the *role* of in mediating VEGF stimulated [MMP] expression of SMCs . Regulation MMP28 FN1 18243246 1871534 Blocking of alpha5beta 1 integrin with anti-alpha5 monoclonal antibody inhibits the induced [MMP] activation *response* appreciably . Regulation MMP28 FURIN 15584904 1345482 Consequently , HGF and BCL-2 family proteins use a furin dependent pathway to promote invasion via TGF-beta and MMP in human malignant glioma cells and the pro-invasive properties of TGF-beta require *dependent* [MMP] activity . Regulation MMP28 GNRH1 10333542 615078 In this study we assessed the *effect* of on [MMP] expression and induction of structural involution of developed corpora lutea of superovulated rats using GnRHa . Regulation MMP28 GPI 11431735 831899 The *effect* of on [matrix metalloproteinase (MMP)] secretion was evaluated by gelatin zymography . Regulation MMP28 HGF 10836994 698106 Here we examined the *effect* of on E1AF and [MMP] gene expression in terms of the invasive potential of the oral squamous cell carcinoma cell line HSC3 . Regulation MMP28 HGF 11027427 738904 However , there was no simple correlation between the levels of MMPs and TIMPs of the cell lines and their different invasion properties or between stimulatory *effects* on [MMP] expression and invasion . Regulation MMP28 HIF1A 19558529 2149629 Impairment of ischaemia induced EPC mobilization in the diabetic mouse model is associated with altered and [MMP/TIMP] *regulation* and represents a novel mechanism underlying defective postischaemic neovascularization in diabetes . Regulation MMP28 ICAM1 12789230 1097341 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and TNF-alpha expression . Regulation MMP28 IFNG 7872603 296630 IL-2 , IL-6 , and had no consistent *effect* on [MMP] production . Regulation MMP28 IFNG 8906257 394155 Supplementation with tryptophan completely overcame the inhibitory *effects* of on [MMP] mRNA expression and metalloproteinase secretion into the media . Regulation MMP28 IFNG 8906257 394177 These results indicate that oxidative tryptophan metabolism mediates the *effects* of on [MMP] gene expression in human fibroblasts . Regulation MMP28 IL10 11792075 901811 The endogenous production of IL-10 in AM of patients with sarcoidosis and the MMP downregulation by exogenous IL-10 suggest an *involvement* of in [MMP] regulation . Regulation MMP28 IL10 19178594 2105829 we also investigated the effect of 1alpha,25 ( OH ) ( 2 ) D ( 3 ) on the secretion of and prostaglandin E ( 2 ) ( PGE ( 2 ) ) , both transcriptional *regulators* of [MMP] expression . Regulation MMP28 IL1A 11747375 889263 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , tumor necrosis factor (TNF)-alpha and on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP28 IL1A 15090411 1237925 and LPS had no *effect* on [MMP/TIMP] production by cultured corneal epithelial cells and keratocytes . Regulation MMP28 IL1B 10616215 575834 and ( d ) test whether the *effect* of on the [MMP] mRNA expression could be detected with in situ hybridization . Regulation MMP28 IL1B 12789230 1097342 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing , IL-4 , and TNF-alpha expression . Regulation MMP28 IL1B 19107653 2018807 Inhibition of histone deacetylases antagonized FGF2 and *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP28 IL1B 21344389 2480457 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Regulation MMP28 IL1B 8906257 394133 Type I collagen gene expression , and abrogated the *effect* of on [MMP] expression . Regulation MMP28 IL2 20463600 2262941 We have used freshly isolated human NK cells and the IL-2 independent NK cell line , YT , to investigate the *effects* of stimulation on NK cell invasion of Matrigel and on [MMP] expression and production . Regulation MMP28 IL21 16682426 1645744 To investigate whether *controls* [MMP] production by intestinal fibroblasts . Regulation MMP28 IL21 16682426 1645835 These results suggest that fibroblasts are a potential target of IL21 in the gut and that *controls* [MMP] secretion by fibroblasts . Regulation MMP28 IL21 17442980 1729759 In this study , we have examined the role of the T cell cytokine IL-21 in Hp-infected gastric mucosa and evaluated whether *regulates* [MMP] production by gastric epithelial cells . Regulation MMP28 IL4 12789230 1097343 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , , and TNF-alpha expression . Regulation MMP28 IL6 20225236 2243870 Although it is known that interleukin (IL)-6 is a key proinflamatory cytokine , it remains unclear how *regulates* [MMP] expression by mononuclear phagocytes . Regulation MMP28 IL6 20225236 2243892 Furthermore , it remains undetermined how in combination with hyperglycemia *affects* [MMP] expression . Regulation MMP28 IL8 12167419 973099 Second , we thus also investigated the *effect* of on [MMP] release in OSCC cells . Regulation MMP28 IL8 15019828 1220984 To evaluate the *effect* of on endometrial stromal cell metalloproteinase ( [MMP] ) activity and invasiveness . Regulation MMP28 IRF3 20483755 2270084 also partially *regulates* expression of other cytokines and [MMP] through activation of c-Jun and the AP-1 promoter site . Regulation MMP28 IRS1 20525764 2301514 *regulates* the cellular differentiation and the [matrix metallopeptidase] expression of preosteoblastic cells . Regulation MMP28 ISL1 19157825 2182209 This study examined the inhibitory *effects* of on phorbol myristate acetate ( PMA ) -induced [MMP] production and its tissue inhibitor of MMP (TIMP) in endothelial cells . Regulation MMP28 ISL1 23327692 2753096 The purpose of this study is to investigate the *effects* of on VEGF and [MMP] expression in highly metastatic human breast cancer cell line , MDA-MB-231 . Regulation MMP28 ISL2 19157825 2182208 This study examined the inhibitory *effects* of on phorbol myristate acetate ( PMA ) -induced [MMP] production and its tissue inhibitor of MMP (TIMP) in endothelial cells . Regulation MMP28 ISL2 23327692 2753095 The purpose of this study is to investigate the *effects* of on VEGF and [MMP] expression in highly metastatic human breast cancer cell line , MDA-MB-231 . Regulation MMP28 ITGA4 12594231 1060803 may be partially *involved* in the [MMP] induction by COOH-HBFN-f . Regulation MMP28 JUN 11861377 917166 These results suggest that nobiletin inhibits tumor cell invasive activity not only by suppressing the expression of MMPs but also augmenting TIMP-1 production in tumor cells , and that the nobiletin mediated inhibition of binding activity is at least partly *involved* in the suppression of [MMP] expression . Regulation MMP28 LEO1 23911909 2840428 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Regulation MMP28 LEP 14629027 1170378 had no *effect* on cytokine and [MMP] production by these cells . Regulation MMP28 LEP 18436234 1908207 Here we investigated the *effects* of , circulating levels of which are typically increased in obese individuals , on [MMP] and collagen expression and MMP activity in isolated cardiac myofibroblasts . Regulation MMP28 LGALS1 19276182 2051349 We conclude that is *involved* in tumor invasion and metastasis by increasing [MMP] expression and reorganizing cytoskeletons in oral cancers and lung adenocarcinoma . Regulation MMP28 LOX 19813219 2168639 Additionally , we also examined the *role* of peptides on SMC proliferation and [matrix metalloproteinase (MMP)] synthesis in these cultures . Regulation MMP28 LPA 11306508 804202 In the current study , the *effect* of on [MMP] expression and invasive activity was investigated . Regulation MMP28 MAP2K1 15252145 1271574 Therefore , these results introduce novel evidence that the antitumor effects of nobiletin are finely regulated by the following intracellular mechanisms : ( 1 ) the inhibition of activity is *involved* in the suppression of [MMP] expression and ( 2 ) the activation of the novel PKCbetaII/epsilon-JNK pathway is associated with the augmentation of TIMP-1 expression . Regulation MMP28 MAP2K1 19833163 2196239 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP28 MAP2K2 19833163 2196240 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP28 MAP2K3 19833163 2196241 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP28 MAP2K4 19833163 2196242 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP28 MAP2K5 19833163 2196243 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP28 MAP2K6 19833163 2196244 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP28 MAP2K7 19833163 2196245 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP28 MAPK1 18171912 1875554 Therefore , , functioning through a BAD independent mechanism *regulates* [MMP] in humans lens epithelial cells . Regulation MMP28 MAPK3 20382513 2287776 However , HG-down regulated MT-1 [MMP] expression was *independent* of activation of and Akt when using their inhibitors of DB98059 ( ERK1/2 ) and LY294002 ( Akt ) alone or in combination . Regulation MMP28 MIF 16872482 1663480 In the present study , we determined the *role* of in RA synovial fibroblast [MMP] production and the underlying signaling mechanisms . Regulation MMP28 MIF 19950249 2184924 The use of different strategies to block MIF action , including an anti-MIF antibody , the MIF inhibitor ISO-1 and knockout mice for the MIF gene , showed that cytokine secretion and [MMP] expression during infection were *regulated* by , suggesting that this cytokine acts in autocrine and paracrine manner upstream in the macrophage activation cascade . Regulation MMP28 MMP12 18980250 1995255 alone did not *affect* other [MMP] expressions . Regulation MMP28 MMP2 11172680 784140 ) activity has been correlated to cancer invasiveness , and membrane type [MMP] ( MT1-MMP ) expressed by tumor cells is *involved* in localizing and activating pro-MMP-2 , a pathway believed to mediate cancer induced tissue breakdown . Regulation MMP28 MMP2 17986262 1845910 These results suggest that , during colon morphogenesis , [MMP] activity is under strict spatio-temporal control , and that the activity of , which is regulated at both the transcriptional and proteolytic activation levels , is very much *involved* in rat colon morphogenesis . Regulation MMP28 MSC 17495113 1778218 The results of this study suggest that function is *controlled* by [MMP] activity , which in turn is regulated by mechanical stimulation of cells . Regulation MMP28 MSC 21856754 2486347 This study investigated the *effects* of on [MMP] synthesis in cardiac fibroblasts ( CFs ) through paracrine actions . Regulation MMP28 MSH2 24530634 2933395 The *effect* of on proliferation , [matrix metalloproteinase (MMP)] secretion , migration and tube formation was examined using human umbilical vein endothelial cells ( HUVECs ) . Regulation MMP28 MSH3 24530634 2933396 The *effect* of on proliferation , [matrix metalloproteinase (MMP)] secretion , migration and tube formation was examined using human umbilical vein endothelial cells ( HUVECs ) . Regulation MMP28 MSH4 24530634 2933397 The *effect* of on proliferation , [matrix metalloproteinase (MMP)] secretion , migration and tube formation was examined using human umbilical vein endothelial cells ( HUVECs ) . Regulation MMP28 MSH5 24530634 2933398 The *effect* of on proliferation , [matrix metalloproteinase (MMP)] secretion , migration and tube formation was examined using human umbilical vein endothelial cells ( HUVECs ) . Regulation MMP28 MSH6 24530634 2933399 The *effect* of on proliferation , [matrix metalloproteinase (MMP)] secretion , migration and tube formation was examined using human umbilical vein endothelial cells ( HUVECs ) . Regulation MMP28 MYCN 12085233 958942 This study investigates the *effect* of and Bcl-2 on [MMP] expression and activation . Regulation MMP28 MYLIP 21279994 2387688 Previously , we described increased expression of miR-155 and miR-146a in rheumatoid arthritis ( RA ) and showed a repressive *effect* of on [matrix metalloproteinase (MMP)] expression in RA synovial fibroblasts ( RASFs ) . Regulation MMP28 NFKB1 17310108 1699523 68 % of Curcumin treated but only 17 % of untreated animals showed no or very few lung metastases , most likely as a consequence of down-regulation of *dependent* [MMP] expression and direct apoptotic effects on circulating tumor cells but not on established metastases . Regulation MMP28 NOX1 12750313 1100715 Because mechanical stretch is further capable of inducing reactive oxygen species ( ROS ) formation via the NAD(P)H oxidase , we assessed whether mechanical stretch enhances [MMP] expression and activity in a *dependent* manner . Regulation MMP28 NOX3 12750313 1100716 Because mechanical stretch is further capable of inducing reactive oxygen species ( ROS ) formation via the NAD(P)H oxidase , we assessed whether mechanical stretch enhances [MMP] expression and activity in a *dependent* manner . Regulation MMP28 NOX4 12750313 1100717 Because mechanical stretch is further capable of inducing reactive oxygen species ( ROS ) formation via the NAD(P)H oxidase , we assessed whether mechanical stretch enhances [MMP] expression and activity in a *dependent* manner . Regulation MMP28 NOX5 12750313 1100714 Because mechanical stretch is further capable of inducing reactive oxygen species ( ROS ) formation via the NAD(P)H oxidase , we assessed whether mechanical stretch enhances [MMP] expression and activity in a *dependent* manner . Regulation MMP28 NPS 9766654 538562 These data indicate that can *regulate* [MMP] activity , which , in turn , could facilitate prostate cancer progression . Regulation MMP28 OLFM4 23161172 2707566 For further insight into the mechanisms underlying OLFM4 mediated suppression of tumor progression , we examined the *effect* of on the expression of integrin and [matrix metalloproteinase (MMP)] , both of which are involved in tumor progression . Regulation MMP28 OSM 18398932 1899445 We investigated secretion from Mycobacterium tuberculosis ( Mtb ) -infected human monocytes/macrophages and the networking *effects* of such OSM on lung fibroblast [MMP] secretion . Regulation MMP28 OTUD7A 23792447 2937872 Further , could *regulate* [MMP] ( matrix metalloproteinase)2 , MMP9 and ICAM1 ( intercellular adhesion molecule ) levels through modulation of the NF-?B ( nuclear factor kappa-light-chain-enhancer of activated B cell ) signaling cascade . Regulation MMP28 PACS1 20626034 2321803 In this study we document the *effects* of from the American Cranberry ( Vaccinium macrocarpon ) on [matrix metalloproteinase (MMP)] activity in DU145 human prostate cancer cells . Regulation MMP28 PACS2 20626034 2321802 In this study we document the *effects* of from the American Cranberry ( Vaccinium macrocarpon ) on [matrix metalloproteinase (MMP)] activity in DU145 human prostate cancer cells . Regulation MMP28 PAF1 23911909 2840426 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Regulation MMP28 PAK1 22416254 2612606 To investigate the *role* of in regulating migration , invasion and [MMP] expression in RA fibroblast-like synoviocytes ( FLS ) . Regulation MMP28 PAK1 23744893 2807174 Together , these data illustrate the complex interaction between the substratum and PRL/PAK1 signaling in human breast cancer cells and suggest a pivotal *role* for PRL dependent tyrosyl phosphorylation in [MMP] secretion . Regulation MMP28 PDLIM7 17913445 1812888 To investigate the *role* of in [MMP] expression in NPC , we cloned the LMP1 gene from NPC samples and transiently expressed it in MRC5 cells ( human lung fibroblasts ) . Regulation MMP28 PGR 12915398 1157529 We examined and compared estrogen receptor (ER) and expression and the *effects* of 17beta-estradiol ( E2 ) and progesterone ( P ) on collagen synthesis and [matrix metalloproteinase (MMP)] activities in the aortic arch and in cultured aortic smooth muscle cells ( ASMC ) of atherosclerosis-susceptible ( C57Bl6/J , B6 ) or -resistant ( C3H/HeJ , C3H ) mice . Regulation MMP28 PIK3CA 23061721 2703262 *dependent* activation of cAMP responsive element binding protein ( CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing [MMP] activity by doxycycline partially reversed FN accumulation in the InsR silenced cells . Regulation MMP28 PIK3R1 23061721 2703263 *dependent* activation of cAMP responsive element binding protein ( CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing [MMP] activity by doxycycline partially reversed FN accumulation in the InsR silenced cells . Regulation MMP28 PLA2G4A 17981679 1845579 [MMP] production in human fibrosarcoma cells and their invasiveness are *regulated* by group IB secretory phospholipase A2 receptor mediated activation of . Regulation MMP28 PLA2R1 17981679 1845580 [MMP] production in human fibrosarcoma cells and their invasiveness are *regulated* by group IB mediated activation of cytosolic phospholipase A2 . Regulation MMP28 PLAT 23565108 2767697 Reactive oxygen species can enhance the *effects* of on [MMP] activation through the loss of caveolin-1 (cav-1) , a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability . Regulation MMP28 PLAU 12117412 997474 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Regulation MMP28 PLAUR 18548111 1984156 In conclusion , this study suggests that the absence of not only *regulates* fibrosis related gene expression and [MMP] activity but also results in ECM deposition . Regulation MMP28 PLG 11204721 785562 The [MMP] are *regulated* at the levels of transcription , zymogen activation by or membrane-type- ( MT ) MMP , and control of enzyme activity by tissue inhibitors of metalloproteinases ( TIMP ) . Regulation MMP28 PPARA 18971601 2014936 The *effect* of inhibitors on [MMP] levels in aspirin treated cells was examined . Regulation MMP28 PQBP1 24961841 2952411 However , little is known about the *effects* of , a smoking status that is more widely harmful to the general population , on [MMP] gene expression in SVs . Regulation MMP28 PTH 14570746 1155597 Although parathyroid tissue induces angiogenesis when autotransplanted and *regulates* both VEGF and [MMP] expression , there are few studies of angiogenesis and angiogenic factors in parathyroid tumors . Regulation MMP28 PTX3 12938822 1133146 The *effects* of on [matrix metalloproteinase (MMP)] activity and cAMP level in HPFBs were measured by immunoassays . Regulation MMP28 PTX3 12938822 1133194 The did not *affect* the [MMP] ( including MMP-1 , MMP-8 , and MMP-13 ) activities of HPFBs . Regulation MMP28 PTX4 12938822 1133145 The *effects* of on [matrix metalloproteinase (MMP)] activity and cAMP level in HPFBs were measured by immunoassays . Regulation MMP28 PTX4 12938822 1133193 The did not *affect* the [MMP] ( including MMP-1 , MMP-8 , and MMP-13 ) activities of HPFBs . Regulation MMP28 RECK 16103099 1444563 , a glycosylphosphatidylinositol (GPI) anchored glycoprotein , negatively *regulates* [matrix metalloproteinases (MMP)] , such as MMP-9 , and inhibits tumor invasion and metastasis . Regulation MMP28 RECK 17088949 1644156 mRNA expression profile of selected ADAM and ADAMTS proteinases ( ADAM-8 , -9 , -10 , -12 , -15 , -17 , and -33 ; ADAMTS-1 , -2 , -15 , -16 , -17 , -18 , and -19 ) , their physiological inhibitors TIMP-1 and TIMP-3 , and , a membrane anchored [MMP] activity *regulator* , was obtained by RT-PCR analysis performed on cells collected by sputum induction from 21 patients with mild to moderate asthma and 17 healthy individuals . Regulation MMP28 RECK 18989628 2022066 Concluding , our results provide evidences that and TIMP-2 are *involved* in the control of ECM remodeling in distinct phases of osteoblast differentiation by modulating [MMP] activities and a multitude of signaling proteins governs these events . Regulation MMP28 RECK 24265116 2921227 Here we investigated the role of ( reversion-inducing-cysteine-rich protein with Kazal motifs ) , a unique membrane anchored [MMP] *regulator* , on IL-18 induced CF migration , and the effect of acetylsalicylic acid (ASA) on this response . Regulation MMP28 RELA 17310108 1699524 68 % of Curcumin treated but only 17 % of untreated animals showed no or very few lung metastases , most likely as a consequence of down-regulation of *dependent* [MMP] expression and direct apoptotic effects on circulating tumor cells but not on established metastases . Regulation MMP28 RHO 18507693 1945087 Our aim was to test the anticancer *effects* of inhibitor , Y-27632 , including possible mechanisms in a highly metastasizing hepatocellular carcinoma ( HCC ) mouse model on its secretion of [matrix metalloproteinase (MMP)] and tumor progression . Regulation MMP28 RLN1 15956693 1422413 In addition , negatively *regulates* expression of endometrial [matrix metalloproteinases (MMP)] , causing decreased endometrial levels of MMP-1 and MMP-3 proteins and increased protein levels of their endogenous inhibitor , tissue inhibitor of metalloproteinase 1 . Regulation MMP28 RLN1 15956693 1422479 The negative *effects* of on [MMP] expression in the endometrium are in distinct contrast to the positive regulation of MMPs previously shown in fibroblasts from other tissues including the cervix . Regulation MMP28 RLN1 22835547 2670990 Our findings provide the first characterization of signaling cascade involved in the *regulation* of any [MMP] by and offer mechanistic insights on how relaxin likely mediates extracellular matrix turnover . Regulation MMP28 RLN2 15956693 1422414 In addition , negatively *regulates* expression of endometrial [matrix metalloproteinases (MMP)] , causing decreased endometrial levels of MMP-1 and MMP-3 proteins and increased protein levels of their endogenous inhibitor , tissue inhibitor of metalloproteinase 1 . Regulation MMP28 RLN2 15956693 1422480 The negative *effects* of on [MMP] expression in the endometrium are in distinct contrast to the positive regulation of MMPs previously shown in fibroblasts from other tissues including the cervix . Regulation MMP28 RLN2 22835547 2670991 Our findings provide the first characterization of signaling cascade involved in the *regulation* of any [MMP] by and offer mechanistic insights on how relaxin likely mediates extracellular matrix turnover . Regulation MMP28 RLN3 15956693 1422415 In addition , negatively *regulates* expression of endometrial [matrix metalloproteinases (MMP)] , causing decreased endometrial levels of MMP-1 and MMP-3 proteins and increased protein levels of their endogenous inhibitor , tissue inhibitor of metalloproteinase 1 . Regulation MMP28 RLN3 15956693 1422481 The negative *effects* of on [MMP] expression in the endometrium are in distinct contrast to the positive regulation of MMPs previously shown in fibroblasts from other tissues including the cervix . Regulation MMP28 RLN3 22835547 2670992 Our findings provide the first characterization of signaling cascade involved in the *regulation* of any [MMP] by and offer mechanistic insights on how relaxin likely mediates extracellular matrix turnover . Regulation MMP28 ROCK1 18507693 1945088 Our aim was to test the anticancer *effects* of inhibitor , Y-27632 , including possible mechanisms in a highly metastasizing hepatocellular carcinoma ( HCC ) mouse model on its secretion of [matrix metalloproteinase (MMP)] and tumor progression . Regulation MMP28 ROCK1 21667311 2494238 The *effect* of inhibitor , Y-27632 on the mRNA expression of the integrin family and [MMP] in gastric carcinoma cells was subsequently examined by Reverse transcriptional ( RT ) -PCR analysis . Regulation MMP28 ROCK2 18507693 1945089 Our aim was to test the anticancer *effects* of inhibitor , Y-27632 , including possible mechanisms in a highly metastasizing hepatocellular carcinoma ( HCC ) mouse model on its secretion of [matrix metalloproteinase (MMP)] and tumor progression . Regulation MMP28 ROCK2 21667311 2494239 The *effect* of inhibitor , Y-27632 on the mRNA expression of the integrin family and [MMP] in gastric carcinoma cells was subsequently examined by Reverse transcriptional ( RT ) -PCR analysis . Regulation MMP28 S100A12 10555038 565741 The *effects* of and VIP on proinflammatory cytokine and [matrix metalloproteinase (MMP)] production by RA synovial cells were estimated by enzyme linked immunosorbent assay , and their messenger RNA ( mRNA ) expression by reverse transcription-polymerase chain reaction ( RT-PCR ) using limiting dilutions of the complementary DNA . Regulation MMP28 SAA1 22076945 2574660 The *effects* of on [MMP/TIMP] expression on RA fibroblast-like synoviocytes ( FLS ) , primary human chondrocytes , and RA/psoriatic arthritis synovial explant cultures were assessed using real-time polymerase chain reaction , enzyme linked immunosorbent assay , antibody protein arrays , and gelatin zymography . Regulation MMP28 SDC1 18378436 1925499 Our results suggest that and beta1 integrin signaling downstream of AG73 *regulate* adhesion and [MMP] production by CAC2 and M1 cells . Regulation MMP28 SERPINE1 21465481 2523656 Under normal physiologic conditions , *controls* the activities of [uPA/tPA/plasmin/MMP] proteolytic activities and thus maintains the tissue homeostasis . Regulation MMP28 SFTPC 20443605 2268353 Beta-amyloid peptide ( Abeta ) was used to induce cytotoxicity in nerve growth factor differentiated PC12 cells , and the *effects* of s-ethyl cysteine ( SEC ) and on anti-inflammatory protection , DNA fragmentation , mitochondrial [membrane potential (MMP)] , and activity of Na ( + ) -K ( + ) -ATPase and caspases were examined . Regulation MMP28 SIRT1 20426787 2315419 We examined if is *involved* in the regulation of [matrix metalloproteinase (MMP)] expression in human dermal fibroblasts . Regulation MMP28 SLC25A14 16941493 1639251 We explored the *effects* of reduced expression on mitochondrial [membrane potential (MMP)] , oxidative stress , ATP levels , and cell viability , under normal and MPP+ induced cytotoxic conditions , in human catecholaminergic SH-SY5Y cells . Regulation MMP28 SPARC 9369945 464087 Because SPARC and monocytes/macrophages are prevalent at sites of inflammation and remodeling in which there is connective tissue turnover , we examined the *effect* of on monocyte [matrix metalloproteinase (MMP)] production . Regulation MMP28 SUMO2 23417988 2843433 Collectively , we show that despite their high homology , are differentially regulated by TNF-a and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP28 SUMO3 23417988 2843432 Collectively , we show that despite their high homology , are differentially regulated by TNF-a and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP28 TBX22 12756268 1090721 Bax-/- Bak-/- double knockout cells fail to undergo [MMP] and cell death in *response* to or NFX induced LMP . Regulation MMP28 TERT 23884427 2861403 Human *regulates* [MMP] expression independently of telomerase activity via NF-?B dependent transcription . Regulation MMP28 TFF3 20131235 2219919 The *effects* of on [matrix metalloproteinase (MMP)] production were measured by enzyme linked immunosorbent assay , and effects on chondrocyte apoptosis were studied by caspase assay and annexin V assay . Regulation MMP28 TGFB1 10329260 613083 Neither tumor necrosis factor-alpha nor , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP28 TGFB1 10508223 649906 The objective of the present study was to determine whether ( TGF-beta ) *regulates* the expression of [matrix metalloproteinases (MMP)] and the tissue inhibitor of MMP (TIMP) in myometrial smooth muscle cells . Regulation MMP28 TGFB1 10508223 649988 In conclusion , the data indicate that myometrial smooth muscle cells express [MMP] and TIMP mRNA and protein , and their expression is differentially *regulated* by . Regulation MMP28 TGFB1 10633007 576619 In conclusion , these results indicate that mesothelial cells express [MMP] and TIMP mRNA and protein , and their expression is differentially *regulated* by , a mechanism that in part may influence the outcome of peritoneal tissue repair and adhesion formation . Regulation MMP28 TGFB1 10650944 662448 There was no effect of these growth factors on gelatinase or TIMP-1 , -2 , and -3 , nor was there an *effect* of on any [MMP] or TIMP examined . Regulation MMP28 TGFB1 11192834 761599 It is known that platelet derived growth factor ( PDGF ) and ( TGF-beta ) are *involved* in the regulation of [MMP] activity and tissue inhibitor of metalloproteinase ( TIMP ) production in non-ocular tissues . Regulation MMP28 TGFB1 11450704 836659 Taken together , the results of the current study show that matrix vesicles produced by growth plate chondrocytes contain MMP-3 , that this enzyme is at least partially responsible for activation of small latent in the matrix , and that 1alpha,25 ( OH ) 2D3 *regulates* [MMP] release from matrix vesicles . Regulation MMP28 TGFB1 12479636 1024052 To determine the *effect* of on the expression of [MMP] and TIMP by human gingival fibroblasts under CsA treatment , human gingival fibroblast cultures were treated with sense oligonucleotides (SON) or antisense oligonucleotides ( AON ) . Regulation MMP28 TGFB1 15247230 1289681 Because transforming growth factor-beta1 ( TGF-beta1 ) promotes tumor invasion in advanced squamous cell carcinomas , the *role* of in the regulation of [MMP] activity in a cellular model of invasive oral squamous cell carcinoma was examined . Regulation MMP28 TGFB1 8706790 371168 We conclude that the *effects* of on [MMP] and TIMP gene expression involve different cellular intermediaries , and suggest that altered composition or modification of TIE binding factors in aging cells may underlie the failure of TGF beta 1-mediated transcription repression . Regulation MMP28 TGFB2 10329260 613084 Neither tumor necrosis factor-alpha nor , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP28 TGFB2 10508223 649907 The objective of the present study was to determine whether ( TGF-beta ) *regulates* the expression of [matrix metalloproteinases (MMP)] and the tissue inhibitor of MMP (TIMP) in myometrial smooth muscle cells . Regulation MMP28 TGFB2 10650944 662449 There was no effect of these growth factors on gelatinase or TIMP-1 , -2 , and -3 , nor was there an *effect* of on any [MMP] or TIMP examined . Regulation MMP28 TGFB2 11192834 761600 It is known that platelet derived growth factor ( PDGF ) and ( TGF-beta ) are *involved* in the regulation of [MMP] activity and tissue inhibitor of metalloproteinase ( TIMP ) production in non-ocular tissues . Regulation MMP28 TGFB3 10329260 613085 Neither tumor necrosis factor-alpha nor , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP28 TGFB3 10508223 649908 The objective of the present study was to determine whether ( TGF-beta ) *regulates* the expression of [matrix metalloproteinases (MMP)] and the tissue inhibitor of MMP (TIMP) in myometrial smooth muscle cells . Regulation MMP28 TGFB3 10650944 662450 There was no effect of these growth factors on gelatinase or TIMP-1 , -2 , and -3 , nor was there an *effect* of on any [MMP] or TIMP examined . Regulation MMP28 TGFB3 11192834 761601 It is known that platelet derived growth factor ( PDGF ) and ( TGF-beta ) are *involved* in the regulation of [MMP] activity and tissue inhibitor of metalloproteinase ( TIMP ) production in non-ocular tissues . Regulation MMP28 THBS2 21479427 2009803 In this study , we examined the *role* of in tumor cell invasion and its association with proteolytic proteins , [matrix metalloproteinase (MMP)] and the plasminogen/plasmin system , including urokinase-type plasminogen activator ( uPA ) , in the human pancreatic cancer cell line PANC-1 . Regulation MMP28 TIMP1 10219984 609143 [MMP] activities are precisely *regulated* by endogenous . Regulation MMP28 TIMP1 7727689 288800 The biological activity of [MMP] is *controlled* by which also depends on the presence of cytokines in the microenvironment . Regulation MMP28 TIMP2 18989628 2022067 Concluding , our results provide evidences that RECK and are *involved* in the control of ECM remodeling in distinct phases of osteoblast differentiation by modulating [MMP] activities and a multitude of signaling proteins governs these events . Regulation MMP28 TIMP2 21696433 2524014 Gene expression of , a [MMP] *regulator* , decreases during laminitis development . Regulation MMP28 TIMP2 22227894 2605497 Using an ALA + TIMP-2 mutant which is devoid of MMP inhibition , but still capable of initiating specific cell signaling cascades , we show that can differentially *affect* [MMP] activity and cellular invasiveness in both an MMP dependent and independent manner . Regulation MMP28 TLR4 18031543 1851932 Together , our results suggest that sHA in melanoma might promote tumor invasiveness by inducing [MMP-] and cytokine-expression , in part in a *dependent* manner , providing new insights into the relationship between cancer and innate immunity . Regulation MMP28 TLR4 21952248 2512559 Furthermore , although it has been shown that Toll-like receptor 4 (TLR4) , a receptor mediating innate immune response , plays an important role in the obesity associated inflammation and insulin resistance , the *effect* of activation in coculture of adipocytes and monocytes on [MMP] production has not been investigated . Regulation MMP28 TMSB4X 16607611 1550842 Because proteinases are important in wound repair , we hypothesized that may *regulate* [matrix metalloproteinase (MMP)] expression in cells that are involved in wound repair . Regulation MMP28 TNF 10329260 613086 Neither nor transforming growth factor-beta , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP28 TNF 11747375 889262 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , and interleukin (IL)-1beta on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP28 TNF 12113550 963836 This study used reverse transcriptase-PCR to investigate the *effects* of on [matrix metalloproteinase (MMP)] mRNA expression in human periodontal ligament fibroblasts . Regulation MMP28 TNF 12789230 1097339 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and expression . Regulation MMP28 TNF 15663564 1350391 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Regulation MMP28 TNF 16106101 1445011 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Regulation MMP28 TNF 16905636 1672843 [MMP] production is largely *dependent* , further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke induced lung disease . Regulation MMP28 TNF 18277865 1872188 The *effect* of on membrane type [(MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MMP28 TNF 19281093 2007637 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Regulation MMP28 TNF 23417988 2843434 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP28 VCAM1 12789230 1097340 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and expression and possibly also by suppressing IL-1beta , IL-4 , and TNF-alpha expression . Regulation MMP28 VEGFA 15604273 1346940 First , TIMP-2 can inhibit cell migration after VEGF stimulation by direct inhibition of [MMP] activity induced in *response* to stimulation . Regulation MMP28 VEGFA 19558529 2149628 Impairment of ischaemia induced EPC mobilization in the diabetic mouse model is associated with altered HIF-1 and [MMP/TIMP] *regulation* and represents a novel mechanism underlying defective postischaemic neovascularization in diabetes . Regulation MMP28 VIP 10555038 565742 The *effects* of CGRP and on proinflammatory cytokine and [matrix metalloproteinase (MMP)] production by RA synovial cells were estimated by enzyme linked immunosorbent assay , and their messenger RNA ( mRNA ) expression by reverse transcription-polymerase chain reaction ( RT-PCR ) using limiting dilutions of the complementary DNA . Regulation MMP28 WASF1 15907837 1426999 The WAVE3 mediated downregulation of p38 activity and [MMP] production is *independent* of the presence of both and WAVE2 , whose expression levels were not affected by loss of WAVE3 . Regulation MMP28 WASF2 15907837 1427000 The WAVE3 mediated downregulation of p38 activity and [MMP] production is *independent* of the presence of both WAVE1 and , whose expression levels were not affected by loss of WAVE3 . Regulation MMP28 WDR61 23911909 2840427 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Regulation MMP28 WNT1 22328140 2630065 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Regulation MMP28 WNT11 22328140 2630066 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Regulation MMP28 WNT16 22328140 2630071 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Regulation MMP28 WNT2 22328140 2630067 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Regulation MMP28 WNT3 22328140 2630068 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Regulation MMP28 WNT4 22328140 2630069 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Regulation MMP28 WNT6 22328140 2630070 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Regulation MMP3 CAPN8 16574073 1543463 is *involved* in the regulation of TNF-alpha induced [matrix metalloproteinase-3] release in a rheumatoid synovial cell line . Regulation MMP3 CAPN8 16574073 1543521 The inhibitors , ALLN ( calpain inhibitor I ) and calpeptin , did not *affect* the intracellular expression of [MMP-3] , but reduced the secretion of MMP-3 in a concentration dependent manner . Regulation MMP3 CAPN8 16574073 1543550 These findings suggest that , particularly mu-calpain , *regulates* [MMP-3] release by rheumatic synovial cells , in addition to exerting its own degradative action on cartilage . Regulation MMP3 EPHB2 15610507 1348298 Taken together , our results suggest that and JNK *play* an important role in the induction of MMP-1 and [MMP-3] by heat shock and that the heat shock induced expression of MMP-1 and MMP-3 is mediated via an IL-6 dependent autocrine mechanism . Regulation MMP3 IL1B 10616215 575848 and ( d ) test whether the *effect* of on the [MMP] mRNA expression could be detected with in situ hybridization . Regulation MMP3 IL1B 12789230 1097412 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing , IL-4 , and TNF-alpha expression . Regulation MMP3 IL1B 12825130 1104522 Colonic SEMFs actively secreted [MMP-3] in *response* to IL-17 , , and TNF-alpha . Regulation MMP3 IL1B 17198194 1680615 Pancreatic periacinar myofibroblasts actively secrete [MMP-3] in *response* to IL-17 , , and TNF-alpha . Regulation MMP3 IL1B 18449943 1932935 Astrocytes constitutively expressed MMP-11 , MMP-14 , and MMP-2 and showed induction of [MMP-3] in *response* to but did not respond to lipopolysaccharide (LPS) . Regulation MMP3 IL1B 19035520 1998623 S100A8 significantly increased the *effect* of on [MMP-3] , MMP-13 , and ADAMTS-5 . Regulation MMP3 IL1B 19107653 2018835 Inhibition of histone deacetylases antagonized FGF2 and *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP3 IL1B 21344389 2480471 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Regulation MMP3 IL1B 8906257 394147 Type I collagen gene expression , and abrogated the *effect* of on [MMP] expression . Regulation MMP3 IL1B 9203094 440258 *Effects* of on [matrix metalloproteinase-3] levels in human periodontal ligament cells . Regulation MMP3 IL1B 9203094 440259 Because IL-1 beta has been strongly associated with inflammatory periodontal disease , the purpose of this in vitro study was to investigate the *role* of on the regulation of [MMP-3] levels in cells derived from the human periodontal ligament ( PDL ) . Regulation MMP3 MAP2K6 19833163 2196342 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP3 OLFM4 23161172 2707580 For further insight into the mechanisms underlying OLFM4 mediated suppression of tumor progression , we examined the *effect* of on the expression of integrin and [matrix metalloproteinase (MMP)] , both of which are involved in tumor progression . Regulation MMP3 PLAT 23565108 2767711 Reactive oxygen species can enhance the *effects* of on [MMP] activation through the loss of caveolin-1 (cav-1) , a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability . Regulation MMP3 PLAU 12117412 997488 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Regulation MMP3 PLAU 20609072 2303963 Moreover , and tissue inhibitor of metalloproteinase ( TIMP ) -3 were *involved* in [MMP-3] regulation during endometriosis . Regulation MMP3 TNF 10329260 613142 Neither nor transforming growth factor-beta , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP3 TNF 11747375 889290 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , and interleukin (IL)-1beta on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP3 TNF 12113550 963850 This study used reverse transcriptase-PCR to investigate the *effects* of on [matrix metalloproteinase (MMP)] mRNA expression in human periodontal ligament fibroblasts . Regulation MMP3 TNF 12789230 1097409 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and expression . Regulation MMP3 TNF 12825130 1104520 Colonic SEMFs actively secreted [MMP-3] in *response* to IL-17 , IL-1beta , and . Regulation MMP3 TNF 15663564 1350405 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Regulation MMP3 TNF 16106101 1445025 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Regulation MMP3 TNF 16905636 1672857 [MMP] production is largely *dependent* , further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke induced lung disease . Regulation MMP3 TNF 18277865 1872202 The *effect* of on membrane type [(MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MMP3 TNF 19281093 2007651 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Regulation MMP3 TNF 19435506 2106941 Quantitative real-time polymerase chain reaction was used to assess the *effect* of or IL-beta stimulation on the expression of [matrix metalloproteinase (MMP)-3] , -9 and -13 , TNF-alpha , TNF receptor 1 (TNF-R1) , TNF receptor 2 (TNF-R2) , IL-1alpha , IL-1beta , IL-1 receptor 1 (IL-1R1) and IL-1 receptor antagonist (IL-1Ra) . Regulation MMP3 TNF 23417988 2843476 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP3 TNF 24062615 2846678 We have demonstrated that budesonide concentration-dependently ( 10 ( -10 ) -10 ( -7 ) M ) inhibited IL-6 , IL-8 , MMP-1 , and [MMP-3] release by HFL-1 cells in *response* to IL-1ß plus . Regulation MMP7 ACE 17308006 1747490 This study sought to determine whether inhibitors can directly *regulate* [MMP] activity and whether this results in positive structural and functional adaptations to the heart . Regulation MMP7 AKT1 20382513 2287837 However , HG-down regulated MT-1 [MMP] expression was *independent* of activation of ERK1/2 and when using their inhibitors of DB98059 ( ERK1/2 ) and LY294002 ( Akt ) alone or in combination . Regulation MMP7 AKT1 23061721 2703334 *dependent* activation of cAMP responsive element binding protein ( CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing [MMP] activity by doxycycline partially reversed FN accumulation in the InsR silenced cells . Regulation MMP7 AKT2 20382513 2287838 However , HG-down regulated MT-1 [MMP] expression was *independent* of activation of ERK1/2 and when using their inhibitors of DB98059 ( ERK1/2 ) and LY294002 ( Akt ) alone or in combination . Regulation MMP7 AKT2 23061721 2703335 *dependent* activation of cAMP responsive element binding protein ( CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing [MMP] activity by doxycycline partially reversed FN accumulation in the InsR silenced cells . Regulation MMP7 AKT3 20382513 2287839 However , HG-down regulated MT-1 [MMP] expression was *independent* of activation of ERK1/2 and when using their inhibitors of DB98059 ( ERK1/2 ) and LY294002 ( Akt ) alone or in combination . Regulation MMP7 AKT3 23061721 2703336 *dependent* activation of cAMP responsive element binding protein ( CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing [MMP] activity by doxycycline partially reversed FN accumulation in the InsR silenced cells . Regulation MMP7 APAF1 22226830 2550127 Altogether , we have for the first time demonstrated the critical *role* of in the regulation of MAPK , ROS , and [MMP] in UVC radiated MEFs and propose that the amplification feedback loop among mitochondrial signal molecules culminates in the demise of the cell . Regulation MMP7 APOB 11701474 878729 Northern blot analysis could not detect an *effect* of native or oxidatively modified low density on [MMP-7] expression . Regulation MMP7 ASCL1 23300791 2712420 We now show that directly *regulates* [matrix metalloproteinase-7 (MMP-7)] and O(6)-methylguanine-DNA methyltransferase ( MGMT ) . Regulation MMP7 ATL1 19144404 2071491 is an aggressive disease characterized by visceral invasion , and ATL *regulates* [matrix metalloproteinase (MMP)] activities of the endothelial cells . Regulation MMP7 ATL2 19144404 2071492 Adult T-cell leukemia (ATL) is an aggressive disease characterized by visceral invasion , and *regulates* [matrix metalloproteinase (MMP)] activities of the endothelial cells . Regulation MMP7 ATL3 19144404 2071493 is an aggressive disease characterized by visceral invasion , and ATL *regulates* [matrix metalloproteinase (MMP)] activities of the endothelial cells . Regulation MMP7 ATP5O 21339745 2420411 We investigated whether the expression and cellular localization of corresponded to the stage of human pancreatic cancer , and its *effect* on [matrix metalloproteinase (MMP)] activation in vitro . Regulation MMP7 BAX 12813466 1103253 The data reported herein indicate that LMP does not suffice to trigger caspase activation and that *dependent* [MMP] is a critical step of LMP induced cell death . Regulation MMP7 BCL2 12085233 958973 This study investigates the *effect* of N-Myc and on [MMP] expression and activation . Regulation MMP7 BCL2 22491967 2613111 Second , we have highlighted that during etoposide or TNF-a treatments , intracellular ROS level , [MMP] and cell death are all *regulated* by caspases and , with caspases acting early in the process . Regulation MMP7 BSG 12553375 1028961 mediated [MMP] *regulation* in tumor and endothelial cells . Regulation MMP7 BSG 12692261 1080502 Our results suggest that during the development of MDR , the expression of is *responsible* for the increased activity of [MMP] in MDR cell lines . Regulation MMP7 BSG 15758150 1417061 This report characterizes the expression pattern of , a putative *regulator* of [MMP] induction , in the rat ovary . Regulation MMP7 BSG 16207318 1464285 The *role* of in [MMP] production and cell invasion in vitro were studied through the co-culture of human CD14+ monocytes or monocytic line THP-1 cells and human fibroblasts , as well as by gel zymography and an invasion assay . Regulation MMP7 BSG 16207318 1464307 Our study demonstrates that the increased expression of on monocytes/macrophages in RA may be *responsible* for elevated [MMP] secretion , cell invasion and CyPA mediated cell migration into the joints , all of which may contribute to the cartilage and bone destruction of RA . Regulation MMP7 BSG 16507143 1574204 The *role* of in [MMP] production and the cells ' invasiveness in vitro were studied by the co-culture of FLS with the human THP-1 cell line or monocytes/macrophages , by gel zymography and by invasion assay . Regulation MMP7 BSG 16507143 1574226 Our studies demonstrated that the overexpression on monocytes/macrophages and FLS in RA patients may be *responsible* for the enhanced [MMP] secretion and activation and for the invasiveness of synoviocytes . Regulation MMP7 BSG 17825230 1795461 To further investigate the *effect* of on neutrophil on [MMP] production by FLS and the invasive potential of FLS in RA , antagonist peptide against EMMPRIN/CD147 ( AP-9 ) was added to the coculture . Regulation MMP7 BSG 17869266 1843063 Therefore , we tested the hypothesis that expression *regulates* [matrix metalloproteinase (MMP)] activity in rat ventricular myocytes in vitro . Regulation MMP7 BSG 17869266 1843107 To determine whether expression *regulates* [matrix metalloproteinase (MMP)] activity , EMMPRIN activity was inhibited by adenoviral expression of an inhibitory mutant of EMMPRIN . Regulation MMP7 BSG 18751374 1956329 Thus *regulates* migration , [MMP] production by SCC cells and deposition of the TN-C matrix . Regulation MMP7 BSG 19003972 2016282 We have analysed the *role* of in the induction of [MMP] genes during mammary gland differentiation and involution . Regulation MMP7 BSG 19003972 2016370 In summary the data argue against a causal *role* for for the induction of [MMP] gene expression during adult mammary gland development . Regulation MMP7 BSG 20369361 2238571 The current results indicate that could thus be *involved* in the early stage of tooth germ development and morphogenesis , possibly by regulating the expression of [MMP] genes . Regulation MMP7 CA1 23192945 2752014 This suggested that both ROS and ( 2+ ) signaling *play* roles in the increased [MMP] via Ca?(i) ( 2+ ) -dependent and/or -independent mechanisms , since ?? ( m ) elevation was reversed by NAC and BAPTA . Regulation MMP7 CA2 24739681 2936339 The results reveal an intericate relationship between homeostasis , the ATP generation ability of cells , SO and ROS production , and *regulation* of [MMP] following infection by bovine adenovirus 3 . Regulation MMP7 CA2 9685651 522146 Of the three major gelatinases found in rat mammary gland at different stages of ontogeny , 60K gelatinase , a *dependent* neutral [MMP] , seems to be involved in involution , as it appears at the late stage of involution . Regulation MMP7 CALCA 16549372 1582311 These results are the first evidence of calcitonin receptor expression on articular chondrocytes and that the chondroprotective *effects* of might involve the inhibition of [MMP] expression . Regulation MMP7 CARM1 18511550 1951939 Furthermore , we show that also *regulates* [MMP] expression at the post-transcriptional level , either positively or negatively . Regulation MMP7 CCR9 15623660 1349156 These studies suggest that the expression and activation of *affect* cancer cell migration , invasion , and [MMP] expression , which together may affect prostate cancer metastasis . Regulation MMP7 CD151 17009258 1634051 Tetraspanin is expressed in osteoarthritic cartilage and is *involved* in pericellular activation of [pro-matrix metalloproteinase 7] in osteoarthritic chondrocytes . Regulation MMP7 CD40 17949416 1894454 Finally , we investigated whether interactions were *involved* in T-cell stimulated [MMP] secretion from macrophages . Regulation MMP7 CDC73 23911909 2840499 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Regulation MMP7 CDH11 22127696 2514864 The objective of this study was to determine if synovial fibroblast [MMP] production is *regulated* by . Regulation MMP7 CDH11 22127696 2514976 These results underscore the existence of a pathway by which *regulates* [MMP] production and has important implications for joint destruction in RA . Regulation MMP7 CPOX 21371008 2453213 [MMP] up-regulation may be a *target* for and prostaglandin ( PG ) receptor inhibition , but the extent and mechanisms of COX independent MMP up-regulation are unclear . Regulation MMP7 CRP 16580524 1543663 We examined the *effect* of on [matrix metalloproteinase (MMP)] and inhibitor expression in endothelial cells and in patients with clinical and subclinical atherosclerosis . Regulation MMP7 CSE 21850498 2574392 We further observed that the levels of IL1ß induced MMP-1 , MMP-3 , [MMP-7] , and MMP-9 mRNA , but not TIMP mRNA levels , were down-regulated in chondrocytes in *response* to . Regulation MMP7 CTNNB1 10362259 619968 Because genetic ablation of matrilysin decreases tumor formation in multiple intestinal neoplasia ( Min ) mice , we propose that *regulation* of [matrilysin] production by accumulation is a contributing factor to intestinal tumorigenesis . Regulation MMP7 CTNNB1 10514384 651561 *regulates* the expression of the [matrix metalloproteinase-7] in human colorectal cancer . Regulation MMP7 CTNNB1 11274170 818980 We have previously observed coordinate *regulation* of the [matrilysin] promoter by and Ets family transcription factors of the PEA3 subfamily . Regulation MMP7 CTNNB1 15313922 1285790 Because can *regulate* [MMP] expression , we investigated the expression of several MMPs and TIMPs in aggressive fibromatosis tumors that develop in Apc+/Apc1638N mice . Regulation MMP7 CTR9 23911909 2840500 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Regulation MMP7 CXCL12 17197427 1724674 Moreover , the inflammatory cytokines TGF-beta1 , IL-1beta , and TNF-alpha up-regulated MMP-2 , MT1-MMP , and/or MMP-9 production in these cells , resulting in a strong stimulation of chemotactic migration through ECM , whereas the chemokine exhibited minor *effects* on [MMP/TIMP] expression and cell invasion . Regulation MMP7 CXCL12 21357602 2415715 *effects* of on [MMP] production by human endometrial cells . Regulation MMP7 CXCL12 21357602 2415737 The aim of this study was to investigate CXCL12 and CXCR4 expression in human endometrium and to see if could *affect* [matrix metalloproteinase (MMP)] production by endometrial stromal and epithelial cells . Regulation MMP7 ECM1 15844197 1418401 The experimental observations suggest that [MMP] activity *regulates* the coordination of early heart organogenesis by affecting ventral closure of the heart and gut tubes , asymmetric cell proliferation in the dorsal mesocardium to drive looping direction , and degradation within the dorsal mesocardium allowing looping to proceed toward completion . Regulation MMP7 ECM2 15844197 1418402 The experimental observations suggest that [MMP] activity *regulates* the coordination of early heart organogenesis by affecting ventral closure of the heart and gut tubes , asymmetric cell proliferation in the dorsal mesocardium to drive looping direction , and degradation within the dorsal mesocardium allowing looping to proceed toward completion . Regulation MMP7 EDN1 12842810 1149588 However , little is known about *regulation* of vascular [MMP] activity in hypertension . Regulation MMP7 EDN1 12842810 1149632 Thus early changes in mediated *regulation* of [MMP] activity were measured in borderline hypertensive rats that develop impaired vasorelaxation and hypertension with chronic exposure to stress . Regulation MMP7 EDN1 14558091 1153716 Recently , it was suggested that , a potent vasoconstrictor , may be *involved* in [MMP] regulation . Regulation MMP7 EDN1 16417466 1554159 In the present study , we have investigated the *effect* of ( i ) ET-1 ( ) and its precursor , big ET-1 , on [MMP] ( matrix metalloproteinase)-2 and MMP-9 synthesis and activity in osteosarcoma tissue , and ( ii ) ET-1 receptor antagonists on cell invasion . Regulation MMP7 EDN1 16503991 1541680 However , the *effect* of Type 2 diabetes and/or on the regulation of ECM and [MMP] gene expression in different vascular beds remains unknown . Regulation MMP7 EDN1 20725136 2306906 We have previously shown that type 2 diabetes promotes remodeling of middle cerebral arteries ( MCA ) characterized by increased media/lumen ( M/L ) ratio and [MMP] activity in an *dependent* manner in the Goto-Kakizaki ( GK ) rat model . Regulation MMP7 EDNRA 12842810 1149566 Recent studies demonstrated that receptors *regulate* cardiac [MMP] activity and fibrosis in DOCA-salt hypertension . Regulation MMP7 EEF1A2 19946014 2240983 Because statins interfere with Rho activation , we investigated the *effect* on COX-2 and [MMP] expressions in the human endothelium . Regulation MMP7 EGF 12851697 1109655 These results suggest that plays also an important *role* in [MMP-7] production of TE-9 cells and that there is a difference not only in EGF-intracellular signaling system but also in regulation mechanisms of MMP-7 transcription by beta-catenin-Tcf and/or PEA3 system between these 2 carcinoma lines . Regulation MMP7 EGF 15138601 1246887 We were therefore interested in addressing the question of whether [MMP-7] could be *regulated* by and in identifying the molecular mechanisms through which this process occurs . Regulation MMP7 EGFR 23614740 2774831 Reactive oxygen species ( ROS ) and activation *play* central roles in UV-induced [MMP] expression through initiating extracellular signal regulated kinase ( ERK ) -mediated AP-1 signalling . Regulation MMP7 ERBB2 18600430 1972315 Our data suggest that HRG-beta induced [MMP-7] expression was *regulated* by mediated AP-1 activation in MCF-7 cells . Regulation MMP7 ESR1 12915398 1157558 We examined and compared and progesterone receptor (PR) expression and the *effects* of 17beta-estradiol ( E2 ) and progesterone ( P ) on collagen synthesis and [matrix metalloproteinase (MMP)] activities in the aortic arch and in cultured aortic smooth muscle cells ( ASMC ) of atherosclerosis-susceptible ( C57Bl6/J , B6 ) or -resistant ( C3H/HeJ , C3H ) mice . Regulation MMP7 ETV1 23076342 2716937 *regulates* [matrix metalloproteinase-7] transcription in LNCaP prostate cancer cells . Regulation MMP7 ETV4 10836994 698099 We have previously reported that the Ets-oncogene family transcription factor positively *regulates* transcription of [MMP] genes in transient expression assays and that overexpression of the E1AF gene confers an invasive phenotype on breast cancer cells . Regulation MMP7 FABP5 20040021 2258539 Transwell Matrigel invasion assay , MTS cell proliferation assay , reverse transcription-polymerase chain reaction , Western blot , and gelatin zymography analysis were used to investigate the *effects* of on cell invasion , growth , and [matrix metalloproteinase (MMP)] production . Regulation MMP7 FGF2 16494848 1528730 *Regulation* of [matrilysin] expression in endothelium by . Regulation MMP7 FGF2 19107653 2018836 Inhibition of histone deacetylases antagonized and IL-1beta *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP7 FLT1 9776730 540222 These data suggest the *role* of in mediating VEGF stimulated [MMP] expression of SMCs . Regulation MMP7 FN1 18243246 1871549 Blocking of alpha5beta 1 integrin with anti-alpha5 monoclonal antibody inhibits the induced [MMP] activation *response* appreciably . Regulation MMP7 FURIN 15584904 1345497 Consequently , HGF and BCL-2 family proteins use a furin dependent pathway to promote invasion via TGF-beta and MMP in human malignant glioma cells and the pro-invasive properties of TGF-beta require *dependent* [MMP] activity . Regulation MMP7 GNRH1 10333542 615093 In this study we assessed the *effect* of on [MMP] expression and induction of structural involution of developed corpora lutea of superovulated rats using GnRHa . Regulation MMP7 GPI 11431735 831914 The *effect* of on [matrix metalloproteinase (MMP)] secretion was evaluated by gelatin zymography . Regulation MMP7 HGF 10836994 698122 Here we examined the *effect* of on E1AF and [MMP] gene expression in terms of the invasive potential of the oral squamous cell carcinoma cell line HSC3 . Regulation MMP7 HGF 11027427 738919 However , there was no simple correlation between the levels of MMPs and TIMPs of the cell lines and their different invasion properties or between stimulatory *effects* on [MMP] expression and invasion . Regulation MMP7 HIF1A 19558529 2149682 Impairment of ischaemia induced EPC mobilization in the diabetic mouse model is associated with altered and [MMP/TIMP] *regulation* and represents a novel mechanism underlying defective postischaemic neovascularization in diabetes . Regulation MMP7 ICAM1 12789230 1097416 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and TNF-alpha expression . Regulation MMP7 IFNG 7872603 296645 IL-2 , IL-6 , and had no consistent *effect* on [MMP] production . Regulation MMP7 IFNG 8906257 394170 Supplementation with tryptophan completely overcame the inhibitory *effects* of on [MMP] mRNA expression and metalloproteinase secretion into the media . Regulation MMP7 IFNG 8906257 394192 These results indicate that oxidative tryptophan metabolism mediates the *effects* of on [MMP] gene expression in human fibroblasts . Regulation MMP7 IL10 11792075 901826 The endogenous production of IL-10 in AM of patients with sarcoidosis and the MMP downregulation by exogenous IL-10 suggest an *involvement* of in [MMP] regulation . Regulation MMP7 IL10 19178594 2105844 we also investigated the effect of 1alpha,25 ( OH ) ( 2 ) D ( 3 ) on the secretion of and prostaglandin E ( 2 ) ( PGE ( 2 ) ) , both transcriptional *regulators* of [MMP] expression . Regulation MMP7 IL1A 11747375 889293 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , tumor necrosis factor (TNF)-alpha and on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP7 IL1A 15090411 1237940 and LPS had no *effect* on [MMP/TIMP] production by cultured corneal epithelial cells and keratocytes . Regulation MMP7 IL1B 10616215 575849 and ( d ) test whether the *effect* of on the [MMP] mRNA expression could be detected with in situ hybridization . Regulation MMP7 IL1B 12789230 1097417 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing , IL-4 , and TNF-alpha expression . Regulation MMP7 IL1B 19107653 2018837 Inhibition of histone deacetylases antagonized FGF2 and *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP7 IL1B 21344389 2480472 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Regulation MMP7 IL1B 8906257 394148 Type I collagen gene expression , and abrogated the *effect* of on [MMP] expression . Regulation MMP7 IL2 20463600 2262956 We have used freshly isolated human NK cells and the IL-2 independent NK cell line , YT , to investigate the *effects* of stimulation on NK cell invasion of Matrigel and on [MMP] expression and production . Regulation MMP7 IL21 16682426 1645781 To investigate whether *controls* [MMP] production by intestinal fibroblasts . Regulation MMP7 IL21 16682426 1645872 These results suggest that fibroblasts are a potential target of IL21 in the gut and that *controls* [MMP] secretion by fibroblasts . Regulation MMP7 IL21 17442980 1729774 In this study , we have examined the role of the T cell cytokine IL-21 in Hp-infected gastric mucosa and evaluated whether *regulates* [MMP] production by gastric epithelial cells . Regulation MMP7 IL4 12789230 1097418 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , , and TNF-alpha expression . Regulation MMP7 IL6 17339835 1720163 A *role* for in the regulation of metalloproteinase ( [MMP)-7] expression by CORM-2 is described . Regulation MMP7 IL6 20225236 2243885 Although it is known that interleukin (IL)-6 is a key proinflamatory cytokine , it remains unclear how *regulates* [MMP] expression by mononuclear phagocytes . Regulation MMP7 IL6 20225236 2243907 Furthermore , it remains undetermined how in combination with hyperglycemia *affects* [MMP] expression . Regulation MMP7 IL8 12167419 973114 Second , we thus also investigated the *effect* of on [MMP] release in OSCC cells . Regulation MMP7 IL8 15019828 1220999 To evaluate the *effect* of on endometrial stromal cell metalloproteinase ( [MMP] ) activity and invasiveness . Regulation MMP7 IRF3 20483755 2270099 also partially *regulates* expression of other cytokines and [MMP] through activation of c-Jun and the AP-1 promoter site . Regulation MMP7 IRS1 20525764 2301529 *regulates* the cellular differentiation and the [matrix metallopeptidase] expression of preosteoblastic cells . Regulation MMP7 ISL1 19157825 2182239 This study examined the inhibitory *effects* of on phorbol myristate acetate ( PMA ) -induced [MMP] production and its tissue inhibitor of MMP (TIMP) in endothelial cells . Regulation MMP7 ISL1 23327692 2753126 The purpose of this study is to investigate the *effects* of on VEGF and [MMP] expression in highly metastatic human breast cancer cell line , MDA-MB-231 . Regulation MMP7 ISL2 19157825 2182238 This study examined the inhibitory *effects* of on phorbol myristate acetate ( PMA ) -induced [MMP] production and its tissue inhibitor of MMP (TIMP) in endothelial cells . Regulation MMP7 ISL2 23327692 2753125 The purpose of this study is to investigate the *effects* of on VEGF and [MMP] expression in highly metastatic human breast cancer cell line , MDA-MB-231 . Regulation MMP7 ITGA4 12594231 1060818 may be partially *involved* in the [MMP] induction by COOH-HBFN-f . Regulation MMP7 ITGAE 19893044 2171465 [Matrilysin] ( Matrix Metalloproteinase-7 ) *regulates* anti-inflammatory and antifibrotic pulmonary dendritic cells that express CD103 ( ) . Regulation MMP7 ITGB7 19893044 2171466 [Matrilysin] ( Matrix Metalloproteinase-7 ) *regulates* anti-inflammatory and antifibrotic pulmonary dendritic cells that express CD103 ( ) . Regulation MMP7 JUN 11861377 917181 These results suggest that nobiletin inhibits tumor cell invasive activity not only by suppressing the expression of MMPs but also augmenting TIMP-1 production in tumor cells , and that the nobiletin mediated inhibition of binding activity is at least partly *involved* in the suppression of [MMP] expression . Regulation MMP7 JUN 18600430 1972316 Our data suggest that HRG-beta induced [MMP-7] expression was *regulated* by HER2 mediated activation in MCF-7 cells . Regulation MMP7 JUN 21814482 2462832 Moreover , H2O2 triggered [MMP-7] production was demonstrated via JNK/c-Jun and ERK/c-Fos activation in an *dependent* manner . Regulation MMP7 LEF1 22686279 2615554 *regulates* proliferation and [MMP-7] transcription in breast cancer cells . Regulation MMP7 LEF1 22686279 2615560 Taken together , our results indicate a pivotal *role* of in the regulation of proliferation and [MMP-7] transcription in breast cancer cells . Regulation MMP7 LEO1 23911909 2840503 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Regulation MMP7 LEP 14629027 1170393 had no *effect* on cytokine and [MMP] production by these cells . Regulation MMP7 LEP 18436234 1908222 Here we investigated the *effects* of , circulating levels of which are typically increased in obese individuals , on [MMP] and collagen expression and MMP activity in isolated cardiac myofibroblasts . Regulation MMP7 LGALS1 19276182 2051364 We conclude that is *involved* in tumor invasion and metastasis by increasing [MMP] expression and reorganizing cytoskeletons in oral cancers and lung adenocarcinoma . Regulation MMP7 LOX 19813219 2168654 Additionally , we also examined the *role* of peptides on SMC proliferation and [matrix metalloproteinase (MMP)] synthesis in these cultures . Regulation MMP7 LPA 11306508 804217 In the current study , the *effect* of on [MMP] expression and invasive activity was investigated . Regulation MMP7 LPA 11701474 878730 Northern blot analysis could not detect an *effect* of native or oxidatively modified low density on [MMP-7] expression . Regulation MMP7 MAP2K1 15252145 1271589 Therefore , these results introduce novel evidence that the antitumor effects of nobiletin are finely regulated by the following intracellular mechanisms : ( 1 ) the inhibition of activity is *involved* in the suppression of [MMP] expression and ( 2 ) the activation of the novel PKCbetaII/epsilon-JNK pathway is associated with the augmentation of TIMP-1 expression . Regulation MMP7 MAP2K1 19833163 2196344 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP7 MAP2K2 19833163 2196345 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP7 MAP2K3 19833163 2196346 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP7 MAP2K4 19833163 2196347 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP7 MAP2K5 19833163 2196348 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP7 MAP2K6 19833163 2196349 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP7 MAP2K7 19833163 2196350 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP7 MAPK1 16848631 1588393 In addition , [MMP-7] was also transcriptionally induced at 6 h of hypoxia in an *dependent* manner . Regulation MMP7 MAPK1 18171912 1875569 Therefore , , functioning through a BAD independent mechanism *regulates* [MMP] in humans lens epithelial cells . Regulation MMP7 MAPK3 16848631 1588394 In addition , [MMP-7] was also transcriptionally induced at 6 h of hypoxia in an *dependent* manner . Regulation MMP7 MAPK3 20382513 2287840 However , HG-down regulated MT-1 [MMP] expression was *independent* of activation of and Akt when using their inhibitors of DB98059 ( ERK1/2 ) and LY294002 ( Akt ) alone or in combination . Regulation MMP7 MIF 16872482 1663495 In the present study , we determined the *role* of in RA synovial fibroblast [MMP] production and the underlying signaling mechanisms . Regulation MMP7 MIF 19950249 2184939 The use of different strategies to block MIF action , including an anti-MIF antibody , the MIF inhibitor ISO-1 and knockout mice for the MIF gene , showed that cytokine secretion and [MMP] expression during infection were *regulated* by , suggesting that this cytokine acts in autocrine and paracrine manner upstream in the macrophage activation cascade . Regulation MMP7 MMP12 18980250 1995270 alone did not *affect* other [MMP] expressions . Regulation MMP7 MMP2 11172680 784176 ) activity has been correlated to cancer invasiveness , and membrane type [MMP] ( MT1-MMP ) expressed by tumor cells is *involved* in localizing and activating pro-MMP-2 , a pathway believed to mediate cancer induced tissue breakdown . Regulation MMP7 MMP2 17986262 1845925 These results suggest that , during colon morphogenesis , [MMP] activity is under strict spatio-temporal control , and that the activity of , which is regulated at both the transcriptional and proteolytic activation levels , is very much *involved* in rat colon morphogenesis . Regulation MMP7 MSC 17495113 1778233 The results of this study suggest that function is *controlled* by [MMP] activity , which in turn is regulated by mechanical stimulation of cells . Regulation MMP7 MSC 21856754 2486362 This study investigated the *effects* of on [MMP] synthesis in cardiac fibroblasts ( CFs ) through paracrine actions . Regulation MMP7 MSH2 24530634 2933470 The *effect* of on proliferation , [matrix metalloproteinase (MMP)] secretion , migration and tube formation was examined using human umbilical vein endothelial cells ( HUVECs ) . Regulation MMP7 MSH3 24530634 2933471 The *effect* of on proliferation , [matrix metalloproteinase (MMP)] secretion , migration and tube formation was examined using human umbilical vein endothelial cells ( HUVECs ) . Regulation MMP7 MSH4 24530634 2933472 The *effect* of on proliferation , [matrix metalloproteinase (MMP)] secretion , migration and tube formation was examined using human umbilical vein endothelial cells ( HUVECs ) . Regulation MMP7 MSH5 24530634 2933473 The *effect* of on proliferation , [matrix metalloproteinase (MMP)] secretion , migration and tube formation was examined using human umbilical vein endothelial cells ( HUVECs ) . Regulation MMP7 MSH6 24530634 2933474 The *effect* of on proliferation , [matrix metalloproteinase (MMP)] secretion , migration and tube formation was examined using human umbilical vein endothelial cells ( HUVECs ) . Regulation MMP7 MSLN 21999204 2547394 *regulated* the expression of [MMP-7] through the ERK ( extracellular-signal regulated kinase ) 1/2 , Akt and JNK ( c-Jun N-terminal kinase ) pathways . Regulation MMP7 MYCN 12085233 958972 This study investigates the *effect* of and Bcl-2 on [MMP] expression and activation . Regulation MMP7 MYLIP 21279994 2387703 Previously , we described increased expression of miR-155 and miR-146a in rheumatoid arthritis ( RA ) and showed a repressive *effect* of on [matrix metalloproteinase (MMP)] expression in RA synovial fibroblasts ( RASFs ) . Regulation MMP7 NFKB1 17310108 1699553 68 % of Curcumin treated but only 17 % of untreated animals showed no or very few lung metastases , most likely as a consequence of down-regulation of *dependent* [MMP] expression and direct apoptotic effects on circulating tumor cells but not on established metastases . Regulation MMP7 NOX1 12750313 1100775 Because mechanical stretch is further capable of inducing reactive oxygen species ( ROS ) formation via the NAD(P)H oxidase , we assessed whether mechanical stretch enhances [MMP] expression and activity in a *dependent* manner . Regulation MMP7 NOX3 12750313 1100776 Because mechanical stretch is further capable of inducing reactive oxygen species ( ROS ) formation via the NAD(P)H oxidase , we assessed whether mechanical stretch enhances [MMP] expression and activity in a *dependent* manner . Regulation MMP7 NOX4 12750313 1100777 Because mechanical stretch is further capable of inducing reactive oxygen species ( ROS ) formation via the NAD(P)H oxidase , we assessed whether mechanical stretch enhances [MMP] expression and activity in a *dependent* manner . Regulation MMP7 NOX5 12750313 1100774 Because mechanical stretch is further capable of inducing reactive oxygen species ( ROS ) formation via the NAD(P)H oxidase , we assessed whether mechanical stretch enhances [MMP] expression and activity in a *dependent* manner . Regulation MMP7 NPS 9766654 538577 These data indicate that can *regulate* [MMP] activity , which , in turn , could facilitate prostate cancer progression . Regulation MMP7 OLFM4 23161172 2707581 For further insight into the mechanisms underlying OLFM4 mediated suppression of tumor progression , we examined the *effect* of on the expression of integrin and [matrix metalloproteinase (MMP)] , both of which are involved in tumor progression . Regulation MMP7 OSM 18398932 1899460 We investigated OSM secretion from Mycobacterium tuberculosis ( Mtb ) -infected human monocytes/macrophages and the networking *effects* of such on lung fibroblast [MMP] secretion . Regulation MMP7 OTUD7A 23792447 2937887 Further , could *regulate* [MMP] ( matrix metalloproteinase)2 , MMP9 and ICAM1 ( intercellular adhesion molecule ) levels through modulation of the NF-?B ( nuclear factor kappa-light-chain-enhancer of activated B cell ) signaling cascade . Regulation MMP7 PACS1 20626034 2321833 In this study we document the *effects* of from the American Cranberry ( Vaccinium macrocarpon ) on [matrix metalloproteinase (MMP)] activity in DU145 human prostate cancer cells . Regulation MMP7 PACS2 20626034 2321832 In this study we document the *effects* of from the American Cranberry ( Vaccinium macrocarpon ) on [matrix metalloproteinase (MMP)] activity in DU145 human prostate cancer cells . Regulation MMP7 PAF1 23911909 2840501 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Regulation MMP7 PAK1 22416254 2612621 To investigate the *role* of in regulating migration , invasion and [MMP] expression in RA fibroblast-like synoviocytes ( FLS ) . Regulation MMP7 PAK1 23744893 2807189 Together , these data illustrate the complex interaction between the substratum and PRL/PAK1 signaling in human breast cancer cells and suggest a pivotal *role* for PRL dependent tyrosyl phosphorylation in [MMP] secretion . Regulation MMP7 PDLIM7 17913445 1812903 To investigate the *role* of in [MMP] expression in NPC , we cloned the LMP1 gene from NPC samples and transiently expressed it in MRC5 cells ( human lung fibroblasts ) . Regulation MMP7 PGR 12915398 1157559 We examined and compared estrogen receptor (ER) and expression and the *effects* of 17beta-estradiol ( E2 ) and progesterone ( P ) on collagen synthesis and [matrix metalloproteinase (MMP)] activities in the aortic arch and in cultured aortic smooth muscle cells ( ASMC ) of atherosclerosis-susceptible ( C57Bl6/J , B6 ) or -resistant ( C3H/HeJ , C3H ) mice . Regulation MMP7 PIK3CA 23061721 2703337 *dependent* activation of cAMP responsive element binding protein ( CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing [MMP] activity by doxycycline partially reversed FN accumulation in the InsR silenced cells . Regulation MMP7 PIK3R1 23061721 2703338 *dependent* activation of cAMP responsive element binding protein ( CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing [MMP] activity by doxycycline partially reversed FN accumulation in the InsR silenced cells . Regulation MMP7 PLA2G4A 17981679 1845609 [MMP] production in human fibrosarcoma cells and their invasiveness are *regulated* by group IB secretory phospholipase A2 receptor mediated activation of . Regulation MMP7 PLA2R1 17981679 1845610 [MMP] production in human fibrosarcoma cells and their invasiveness are *regulated* by group IB mediated activation of cytosolic phospholipase A2 . Regulation MMP7 PLAT 23565108 2767712 Reactive oxygen species can enhance the *effects* of on [MMP] activation through the loss of caveolin-1 (cav-1) , a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability . Regulation MMP7 PLAU 12117412 997489 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Regulation MMP7 PLAUR 18548111 1984171 In conclusion , this study suggests that the absence of not only *regulates* fibrosis related gene expression and [MMP] activity but also results in ECM deposition . Regulation MMP7 PLG 11204721 785577 The [MMP] are *regulated* at the levels of transcription , zymogen activation by or membrane-type- ( MT ) MMP , and control of enzyme activity by tissue inhibitors of metalloproteinases ( TIMP ) . Regulation MMP7 PPARA 18971601 2014951 The *effect* of inhibitors on [MMP] levels in aspirin treated cells was examined . Regulation MMP7 PQBP1 24961841 2952426 However , little is known about the *effects* of , a smoking status that is more widely harmful to the general population , on [MMP] gene expression in SVs . Regulation MMP7 PTEN 14516315 1147164 Close correlation between PTEN on MMP-7 expression provided a novel insight into the regulatory *effects* of on [MMP-7] expression in gastric carcinoma . Regulation MMP7 PTH 14570746 1155612 Although parathyroid tissue induces angiogenesis when autotransplanted and *regulates* both VEGF and [MMP] expression , there are few studies of angiogenesis and angiogenic factors in parathyroid tumors . Regulation MMP7 PTX3 12938822 1133176 The *effects* of on [matrix metalloproteinase (MMP)] activity and cAMP level in HPFBs were measured by immunoassays . Regulation MMP7 PTX3 12938822 1133224 The did not *affect* the [MMP] ( including MMP-1 , MMP-8 , and MMP-13 ) activities of HPFBs . Regulation MMP7 PTX4 12938822 1133175 The *effects* of on [matrix metalloproteinase (MMP)] activity and cAMP level in HPFBs were measured by immunoassays . Regulation MMP7 PTX4 12938822 1133223 The did not *affect* the [MMP] ( including MMP-1 , MMP-8 , and MMP-13 ) activities of HPFBs . Regulation MMP7 RECK 16103099 1444578 , a glycosylphosphatidylinositol (GPI) anchored glycoprotein , negatively *regulates* [matrix metalloproteinases (MMP)] , such as MMP-9 , and inhibits tumor invasion and metastasis . Regulation MMP7 RECK 17088949 1644171 mRNA expression profile of selected ADAM and ADAMTS proteinases ( ADAM-8 , -9 , -10 , -12 , -15 , -17 , and -33 ; ADAMTS-1 , -2 , -15 , -16 , -17 , -18 , and -19 ) , their physiological inhibitors TIMP-1 and TIMP-3 , and , a membrane anchored [MMP] activity *regulator* , was obtained by RT-PCR analysis performed on cells collected by sputum induction from 21 patients with mild to moderate asthma and 17 healthy individuals . Regulation MMP7 RECK 18989628 2022096 Concluding , our results provide evidences that and TIMP-2 are *involved* in the control of ECM remodeling in distinct phases of osteoblast differentiation by modulating [MMP] activities and a multitude of signaling proteins governs these events . Regulation MMP7 RECK 24265116 2921242 Here we investigated the role of ( reversion-inducing-cysteine-rich protein with Kazal motifs ) , a unique membrane anchored [MMP] *regulator* , on IL-18 induced CF migration , and the effect of acetylsalicylic acid (ASA) on this response . Regulation MMP7 RELA 17310108 1699554 68 % of Curcumin treated but only 17 % of untreated animals showed no or very few lung metastases , most likely as a consequence of down-regulation of *dependent* [MMP] expression and direct apoptotic effects on circulating tumor cells but not on established metastases . Regulation MMP7 RHO 18507693 1945132 Our aim was to test the anticancer *effects* of inhibitor , Y-27632 , including possible mechanisms in a highly metastasizing hepatocellular carcinoma ( HCC ) mouse model on its secretion of [matrix metalloproteinase (MMP)] and tumor progression . Regulation MMP7 RLN1 15956693 1422458 In addition , negatively *regulates* expression of endometrial [matrix metalloproteinases (MMP)] , causing decreased endometrial levels of MMP-1 and MMP-3 proteins and increased protein levels of their endogenous inhibitor , tissue inhibitor of metalloproteinase 1 . Regulation MMP7 RLN1 15956693 1422524 The negative *effects* of on [MMP] expression in the endometrium are in distinct contrast to the positive regulation of MMPs previously shown in fibroblasts from other tissues including the cervix . Regulation MMP7 RLN1 22835547 2671035 Our findings provide the first characterization of signaling cascade involved in the *regulation* of any [MMP] by and offer mechanistic insights on how relaxin likely mediates extracellular matrix turnover . Regulation MMP7 RLN2 15956693 1422459 In addition , negatively *regulates* expression of endometrial [matrix metalloproteinases (MMP)] , causing decreased endometrial levels of MMP-1 and MMP-3 proteins and increased protein levels of their endogenous inhibitor , tissue inhibitor of metalloproteinase 1 . Regulation MMP7 RLN2 15956693 1422525 The negative *effects* of on [MMP] expression in the endometrium are in distinct contrast to the positive regulation of MMPs previously shown in fibroblasts from other tissues including the cervix . Regulation MMP7 RLN2 22835547 2671036 Our findings provide the first characterization of signaling cascade involved in the *regulation* of any [MMP] by and offer mechanistic insights on how relaxin likely mediates extracellular matrix turnover . Regulation MMP7 RLN3 15956693 1422460 In addition , negatively *regulates* expression of endometrial [matrix metalloproteinases (MMP)] , causing decreased endometrial levels of MMP-1 and MMP-3 proteins and increased protein levels of their endogenous inhibitor , tissue inhibitor of metalloproteinase 1 . Regulation MMP7 RLN3 15956693 1422526 The negative *effects* of on [MMP] expression in the endometrium are in distinct contrast to the positive regulation of MMPs previously shown in fibroblasts from other tissues including the cervix . Regulation MMP7 RLN3 22835547 2671037 Our findings provide the first characterization of signaling cascade involved in the *regulation* of any [MMP] by and offer mechanistic insights on how relaxin likely mediates extracellular matrix turnover . Regulation MMP7 ROCK1 18507693 1945133 Our aim was to test the anticancer *effects* of inhibitor , Y-27632 , including possible mechanisms in a highly metastasizing hepatocellular carcinoma ( HCC ) mouse model on its secretion of [matrix metalloproteinase (MMP)] and tumor progression . Regulation MMP7 ROCK1 21667311 2494268 The *effect* of inhibitor , Y-27632 on the mRNA expression of the integrin family and [MMP] in gastric carcinoma cells was subsequently examined by Reverse transcriptional ( RT ) -PCR analysis . Regulation MMP7 ROCK2 18507693 1945134 Our aim was to test the anticancer *effects* of inhibitor , Y-27632 , including possible mechanisms in a highly metastasizing hepatocellular carcinoma ( HCC ) mouse model on its secretion of [matrix metalloproteinase (MMP)] and tumor progression . Regulation MMP7 ROCK2 21667311 2494269 The *effect* of inhibitor , Y-27632 on the mRNA expression of the integrin family and [MMP] in gastric carcinoma cells was subsequently examined by Reverse transcriptional ( RT ) -PCR analysis . Regulation MMP7 S100A12 10555038 565771 The *effects* of and VIP on proinflammatory cytokine and [matrix metalloproteinase (MMP)] production by RA synovial cells were estimated by enzyme linked immunosorbent assay , and their messenger RNA ( mRNA ) expression by reverse transcription-polymerase chain reaction ( RT-PCR ) using limiting dilutions of the complementary DNA . Regulation MMP7 SAA1 22076945 2574675 The *effects* of on [MMP/TIMP] expression on RA fibroblast-like synoviocytes ( FLS ) , primary human chondrocytes , and RA/psoriatic arthritis synovial explant cultures were assessed using real-time polymerase chain reaction , enzyme linked immunosorbent assay , antibody protein arrays , and gelatin zymography . Regulation MMP7 SDC1 18378436 1925514 Our results suggest that and beta1 integrin signaling downstream of AG73 *regulate* adhesion and [MMP] production by CAC2 and M1 cells . Regulation MMP7 SDC2 22227189 2544569 The cell surface heparan sulfate proteoglycan *regulates* the activation of [matrix metalloproteinase-7 (MMP-7)] as a docking receptor . Regulation MMP7 SERPINE1 21465481 2523671 Under normal physiologic conditions , *controls* the activities of [uPA/tPA/plasmin/MMP] proteolytic activities and thus maintains the tissue homeostasis . Regulation MMP7 SFTPC 20443605 2268368 Beta-amyloid peptide ( Abeta ) was used to induce cytotoxicity in nerve growth factor differentiated PC12 cells , and the *effects* of s-ethyl cysteine ( SEC ) and on anti-inflammatory protection , DNA fragmentation , mitochondrial [membrane potential (MMP)] , and activity of Na ( + ) -K ( + ) -ATPase and caspases were examined . Regulation MMP7 SIRT1 20426787 2315434 We examined if is *involved* in the regulation of [matrix metalloproteinase (MMP)] expression in human dermal fibroblasts . Regulation MMP7 SLC25A14 16941493 1639266 We explored the *effects* of reduced expression on mitochondrial [membrane potential (MMP)] , oxidative stress , ATP levels , and cell viability , under normal and MPP+ induced cytotoxic conditions , in human catecholaminergic SH-SY5Y cells . Regulation MMP7 SOX18 22292085 2545866 The *regulates* the expression of [matrix metalloproteinase 7] and guidance molecules in human endothelial cells . Regulation MMP7 SPARC 9369945 464102 Because SPARC and monocytes/macrophages are prevalent at sites of inflammation and remodeling in which there is connective tissue turnover , we examined the *effect* of on monocyte [matrix metalloproteinase (MMP)] production . Regulation MMP7 STAT3 11922392 926429 Transient transfection with dominant negative STAT3 inhibited FGF-1 induced transactivation of the matrilysin promoter indicating that *plays* an important role in FGF1 induced [matrilysin] expression . Regulation MMP7 SUMO2 23417988 2843478 Collectively , we show that despite their high homology , are differentially regulated by TNF-a and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP7 SUMO3 23417988 2843477 Collectively , we show that despite their high homology , are differentially regulated by TNF-a and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP7 TBX22 12756268 1090736 Bax-/- Bak-/- double knockout cells fail to undergo [MMP] and cell death in *response* to or NFX induced LMP . Regulation MMP7 TERT 23884427 2861418 Human *regulates* [MMP] expression independently of telomerase activity via NF-?B dependent transcription . Regulation MMP7 TFF3 20131235 2219934 The *effects* of on [matrix metalloproteinase (MMP)] production were measured by enzyme linked immunosorbent assay , and effects on chondrocyte apoptosis were studied by caspase assay and annexin V assay . Regulation MMP7 TGFB1 10329260 613143 Neither tumor necrosis factor-alpha nor , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP7 TGFB1 10508223 649951 The objective of the present study was to determine whether ( TGF-beta ) *regulates* the expression of [matrix metalloproteinases (MMP)] and the tissue inhibitor of MMP (TIMP) in myometrial smooth muscle cells . Regulation MMP7 TGFB1 10508223 650003 In conclusion , the data indicate that myometrial smooth muscle cells express [MMP] and TIMP mRNA and protein , and their expression is differentially *regulated* by . Regulation MMP7 TGFB1 10633007 576634 In conclusion , these results indicate that mesothelial cells express [MMP] and TIMP mRNA and protein , and their expression is differentially *regulated* by , a mechanism that in part may influence the outcome of peritoneal tissue repair and adhesion formation . Regulation MMP7 TGFB1 10650944 662493 There was no effect of these growth factors on gelatinase or TIMP-1 , -2 , and -3 , nor was there an *effect* of on any [MMP] or TIMP examined . Regulation MMP7 TGFB1 11192834 761644 It is known that platelet derived growth factor ( PDGF ) and ( TGF-beta ) are *involved* in the regulation of [MMP] activity and tissue inhibitor of metalloproteinase ( TIMP ) production in non-ocular tissues . Regulation MMP7 TGFB1 11450704 836674 Taken together , the results of the current study show that matrix vesicles produced by growth plate chondrocytes contain MMP-3 , that this enzyme is at least partially responsible for activation of small latent in the matrix , and that 1alpha,25 ( OH ) 2D3 *regulates* [MMP] release from matrix vesicles . Regulation MMP7 TGFB1 12479636 1024067 To determine the *effect* of on the expression of [MMP] and TIMP by human gingival fibroblasts under CsA treatment , human gingival fibroblast cultures were treated with sense oligonucleotides (SON) or antisense oligonucleotides ( AON ) . Regulation MMP7 TGFB1 15247230 1289696 Because transforming growth factor-beta1 ( TGF-beta1 ) promotes tumor invasion in advanced squamous cell carcinomas , the *role* of in the regulation of [MMP] activity in a cellular model of invasive oral squamous cell carcinoma was examined . Regulation MMP7 TGFB1 8706790 371183 We conclude that the *effects* of on [MMP] and TIMP gene expression involve different cellular intermediaries , and suggest that altered composition or modification of TIE binding factors in aging cells may underlie the failure of TGF beta 1-mediated transcription repression . Regulation MMP7 TGFB2 10329260 613144 Neither tumor necrosis factor-alpha nor , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP7 TGFB2 10508223 649952 The objective of the present study was to determine whether ( TGF-beta ) *regulates* the expression of [matrix metalloproteinases (MMP)] and the tissue inhibitor of MMP (TIMP) in myometrial smooth muscle cells . Regulation MMP7 TGFB2 10650944 662494 There was no effect of these growth factors on gelatinase or TIMP-1 , -2 , and -3 , nor was there an *effect* of on any [MMP] or TIMP examined . Regulation MMP7 TGFB2 11192834 761645 It is known that platelet derived growth factor ( PDGF ) and ( TGF-beta ) are *involved* in the regulation of [MMP] activity and tissue inhibitor of metalloproteinase ( TIMP ) production in non-ocular tissues . Regulation MMP7 TGFB3 10329260 613145 Neither tumor necrosis factor-alpha nor , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP7 TGFB3 10508223 649953 The objective of the present study was to determine whether ( TGF-beta ) *regulates* the expression of [matrix metalloproteinases (MMP)] and the tissue inhibitor of MMP (TIMP) in myometrial smooth muscle cells . Regulation MMP7 TGFB3 10650944 662495 There was no effect of these growth factors on gelatinase or TIMP-1 , -2 , and -3 , nor was there an *effect* of on any [MMP] or TIMP examined . Regulation MMP7 TGFB3 11192834 761646 It is known that platelet derived growth factor ( PDGF ) and ( TGF-beta ) are *involved* in the regulation of [MMP] activity and tissue inhibitor of metalloproteinase ( TIMP ) production in non-ocular tissues . Regulation MMP7 THBS2 21479427 2009818 In this study , we examined the *role* of in tumor cell invasion and its association with proteolytic proteins , [matrix metalloproteinase (MMP)] and the plasminogen/plasmin system , including urokinase-type plasminogen activator ( uPA ) , in the human pancreatic cancer cell line PANC-1 . Regulation MMP7 TIMP1 10219984 609158 [MMP] activities are precisely *regulated* by endogenous . Regulation MMP7 TIMP1 18385523 1899231 Our data demonstrate that interacts with matrix metalloproteinases and *regulates* [matrilysin] activity during airway epithelial repair . Regulation MMP7 TIMP1 7727689 288815 The biological activity of [MMP] is *controlled* by which also depends on the presence of cytokines in the microenvironment . Regulation MMP7 TIMP2 18989628 2022097 Concluding , our results provide evidences that RECK and are *involved* in the control of ECM remodeling in distinct phases of osteoblast differentiation by modulating [MMP] activities and a multitude of signaling proteins governs these events . Regulation MMP7 TIMP2 21696433 2524029 Gene expression of , a [MMP] *regulator* , decreases during laminitis development . Regulation MMP7 TIMP2 22227894 2605512 Using an ALA + TIMP-2 mutant which is devoid of MMP inhibition , but still capable of initiating specific cell signaling cascades , we show that can differentially *affect* [MMP] activity and cellular invasiveness in both an MMP dependent and independent manner . Regulation MMP7 TLR4 18031543 1851947 Together , our results suggest that sHA in melanoma might promote tumor invasiveness by inducing [MMP-] and cytokine-expression , in part in a *dependent* manner , providing new insights into the relationship between cancer and innate immunity . Regulation MMP7 TLR4 21952248 2512574 Furthermore , although it has been shown that Toll-like receptor 4 (TLR4) , a receptor mediating innate immune response , plays an important role in the obesity associated inflammation and insulin resistance , the *effect* of activation in coculture of adipocytes and monocytes on [MMP] production has not been investigated . Regulation MMP7 TMSB4X 16607611 1550857 Because proteinases are important in wound repair , we hypothesized that may *regulate* [matrix metalloproteinase (MMP)] expression in cells that are involved in wound repair . Regulation MMP7 TNF 10329260 613146 Neither nor transforming growth factor-beta , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP7 TNF 11747375 889292 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , and interleukin (IL)-1beta on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP7 TNF 12113550 963851 This study used reverse transcriptase-PCR to investigate the *effects* of on [matrix metalloproteinase (MMP)] mRNA expression in human periodontal ligament fibroblasts . Regulation MMP7 TNF 12789230 1097414 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and expression . Regulation MMP7 TNF 15663564 1350406 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Regulation MMP7 TNF 16106101 1445026 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Regulation MMP7 TNF 16905636 1672858 [MMP] production is largely *dependent* , further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke induced lung disease . Regulation MMP7 TNF 18277865 1872203 The *effect* of on membrane type [(MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MMP7 TNF 19281093 2007652 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Regulation MMP7 TNF 23417988 2843479 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP7 VCAM1 12789230 1097415 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and expression and possibly also by suppressing IL-1beta , IL-4 , and TNF-alpha expression . Regulation MMP7 VEGFA 15604273 1346955 First , TIMP-2 can inhibit cell migration after VEGF stimulation by direct inhibition of [MMP] activity induced in *response* to stimulation . Regulation MMP7 VEGFA 19558529 2149681 Impairment of ischaemia induced EPC mobilization in the diabetic mouse model is associated with altered HIF-1 and [MMP/TIMP] *regulation* and represents a novel mechanism underlying defective postischaemic neovascularization in diabetes . Regulation MMP7 VIP 10555038 565772 The *effects* of CGRP and on proinflammatory cytokine and [matrix metalloproteinase (MMP)] production by RA synovial cells were estimated by enzyme linked immunosorbent assay , and their messenger RNA ( mRNA ) expression by reverse transcription-polymerase chain reaction ( RT-PCR ) using limiting dilutions of the complementary DNA . Regulation MMP7 WASF1 15907837 1427031 The WAVE3 mediated downregulation of p38 activity and [MMP] production is *independent* of the presence of both and WAVE2 , whose expression levels were not affected by loss of WAVE3 . Regulation MMP7 WASF2 15907837 1427032 The WAVE3 mediated downregulation of p38 activity and [MMP] production is *independent* of the presence of both WAVE1 and , whose expression levels were not affected by loss of WAVE3 . Regulation MMP7 WDR61 23911909 2840502 In the present study , we investigated the *role* of in the production of [matrix metalloproteinase (MMP)] in primary vascular smooth muscle cells ( VSMCs ) . Regulation MMP7 WNT1 22328140 2630170 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Regulation MMP7 WNT11 22328140 2630171 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Regulation MMP7 WNT16 22328140 2630176 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Regulation MMP7 WNT2 22328140 2630172 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Regulation MMP7 WNT3 22328140 2630173 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Regulation MMP7 WNT4 22328140 2630174 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Regulation MMP7 WNT6 22328140 2630175 The aim of this study was to investigate the *role* of signaling in interleukin-1ß (IL-1ß) induced [MMP] expression in human chondrocytes . Regulation MMP8 IL1B 10616215 575850 and ( d ) test whether the *effect* of on the [MMP] mRNA expression could be detected with in situ hybridization . Regulation MMP8 IL1B 12789230 1097422 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing , IL-4 , and TNF-alpha expression . Regulation MMP8 IL1B 14602136 1161648 The data indicate that [MMP-8] overexpression in OVCAs is *regulated* by and that pro-inflammatory cytokines may promote the invasive potential of ovarian cancer . Regulation MMP8 IL1B 19107653 2018839 Inhibition of histone deacetylases antagonized FGF2 and *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP8 IL1B 21344389 2480473 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Regulation MMP8 IL1B 8906257 394149 Type I collagen gene expression , and abrogated the *effect* of on [MMP] expression . Regulation MMP8 MAP2K6 19833163 2196356 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP8 OLFM4 23161172 2707582 For further insight into the mechanisms underlying OLFM4 mediated suppression of tumor progression , we examined the *effect* of on the expression of integrin and [matrix metalloproteinase (MMP)] , both of which are involved in tumor progression . Regulation MMP8 PLAT 23565108 2767713 Reactive oxygen species can enhance the *effects* of on [MMP] activation through the loss of caveolin-1 (cav-1) , a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability . Regulation MMP8 PLAU 12117412 997490 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Regulation MMP8 TNF 10329260 613150 Neither nor transforming growth factor-beta , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP8 TNF 11747375 889294 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , and interleukin (IL)-1beta on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP8 TNF 12113550 963852 This study used reverse transcriptase-PCR to investigate the *effects* of on [matrix metalloproteinase (MMP)] mRNA expression in human periodontal ligament fibroblasts . Regulation MMP8 TNF 12789230 1097419 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and expression . Regulation MMP8 TNF 15663564 1350407 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Regulation MMP8 TNF 16106101 1445027 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Regulation MMP8 TNF 16905636 1672859 [MMP] production is largely *dependent* , further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke induced lung disease . Regulation MMP8 TNF 18277865 1872204 The *effect* of on membrane type [(MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MMP8 TNF 19281093 2007653 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Regulation MMP8 TNF 23417988 2843482 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP9 ALOX5 20153347 2248523 Episodic exposure to acrolein-rich pollutants has been linked to acute myocardial infarction , and <5-lipoxygenase (5-LO)> is *involved* in the production of [matrix metalloproteinase-9 (MMP-9)] , which destabilizes atherosclerotic plaques . Regulation MMP9 ANGPT1 14615417 1163796 interactions *regulate* [mmp-9] expression and retinal neovascularization . Regulation MMP9 CAPN8 16877562 1638726 Homocysteine mediated activation and mitochondrial translocation of *regulates* [MMP-9] in MVEC . Regulation MMP9 CAPN8 16877562 1638754 Our observations suggested that *regulates* Hcy induced [MMP-9] expression and activity . Regulation MMP9 CAPN8 16877562 1638784 Furthermore , studies with pharmacological inhibitors of calpain ( calpeptin and calpain-1 inhibitor ) , ERK ( PD-98059 ) and the mitochondrial uncoupler FCCP suggested that and ERK-1/2 are the major events within the Hcy/MMP-9 signal axis and that intramitochondrial oxidative stress *regulates* [MMP-9] via ERK-1/2 signal cascade . Regulation MMP9 CTGF 21914781 2497172 *Effect* of on FGF2 induced proliferation and [MMP9] and MMP13 productions by chondrocytes . Regulation MMP9 CTGF 21914781 2497175 Next , we examined the combinational *effects* of and FGF2 on the proliferation of and [matrix metalloproteinase (MMP)-9] and -13 productions by cultured chondrocytes . Regulation MMP9 EPHB2 11315098 765097 In the current study , we examined the *role* of JNK- and dependent signaling modules in the regulation of [MMP-9] production and the invasive behavior of the human glioblastoma cell line SNB19 , in which JNK/ERK1 is constitutively activated . Regulation MMP9 EPHB2 11709424 879805 To determine the *role* of in IL-1 beta stimulated [MMP-9] induction , we treated cells with the specific ERK pathway inhibitor PD-98059 at different time intervals after IL-1 beta stimulation . Regulation MMP9 EPHB2 15492828 1321620 Using chemical inhibitors and dominant negative mutants of MAPKs , we provide evidence that while both p38 MAPK and ERKs are required for TGF-beta induced MCF10A cell migration and invasion , TGF-beta induced MMP-2 and [MMP-9] expression depends on p38 MAPK signaling , but is *independent* of activity . Regulation MMP9 EPHB2 15728252 1382903 However , alpha3beta1 was not required for RasV12 mediated activation of ERK or for *dependent* [MMP-9] promoter activity . Regulation MMP9 EPHB2 20458747 2307547 12-O-tetradecanoylphorbol-13-acetate induced invasion/migration of glioblastoma cells through activating *dependent* [MMP-9] expression . Regulation MMP9 EPHB2 20638438 2322034 siRNA and inhibitor studies suggested *involvement* of Focal adhesion kinase ( FAK ) , Phosphatidyl-inositol-3-kinase (PI-3K) , and nuclear factor-kappaB ( NF?B ) in FN-mediated [MMP-9] induction . Regulation MMP9 EPHB2 20718733 2345725 By using specific inhibitors , it was demonstrated that and NF-?B signalling , but not JNK and p38 signalling , were *involved* in PMA stimulated [MMP-9] activation . Regulation MMP9 EPHB2 21679050 2562297 However , transfection with a dominant negative form of the Ras protein ( Ras ( N17 ) ) inhibited the ERK activation and MMP-9 and -13 mRNA expressions induced by IL-1ß , which supported the *involvement* of signalling in IL-1ß induced [MMP-9] and -13 expressions . Regulation MMP9 EPHB2 22519702 2618490 We determined the *effects* of Rac1 and on [MMP-9] expression driven by SP-1WT ( wild-type ) and the SP-1 mutants T578A , S586A and S587A . Regulation MMP9 EPHB2 22835547 2670977 Studies using chemical inhibitors and siRNAs to signaling molecules showed that PI3K , Akt , and PKC-? and the transcription factors Elk-1 , c-fos and , to a lesser extent , NF-?B are *involved* in relaxin 's induction of [MMP-9] . Regulation MMP9 EPHB2 23295196 2798676 Moreover , exogenous AngII resulted in increases in Smad2 activation and [MMP-9] production , in an *dependent* manner . Regulation MMP9 IFI27 21063843 2344976 *Effects* of gene transfer on the expression of Bax , Bcl-2 , VEGF and [MMP-9] in the transplanted liver tumors in nude mice . Regulation MMP9 IL1B 10616215 575851 and ( d ) test whether the *effect* of on the [MMP] mRNA expression could be detected with in situ hybridization . Regulation MMP9 IL1B 10967046 728287 *Regulation* of collagenase , stromelysin , and [gelatinase B] in human conjunctival and conjunctivochalasis fibroblasts by and tumor necrosis factor-alpha . Regulation MMP9 IL1B 11029344 739832 Airway macrophages from smokers released greater amounts of [MMP-9] and TIMP-1 at baseline and in *response* to and LPS than did those of nonsmokers . Regulation MMP9 IL1B 12789230 1097427 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing , IL-4 , and TNF-alpha expression . Regulation MMP9 IL1B 15037119 1224006 In this study , we have investigated the *roles* of and mitogen activated protein kinases in [MMP-9] induction in the retina . Regulation MMP9 IL1B 15458430 1301526 TNF-alpha and mediated *regulation* of [MMP-9] and TIMP-1 in renal proximal tubular cells . Regulation MMP9 IL1B 15458430 1301538 The differential *effects* of TNF-alpha and on proximal tubular [MMP-9] and TIMP-1 expression are mediated through the TNF-RI , the IL-1-RI and the different signaling pathways of PKC , ERK1/2 , and p38 MAPK . Regulation MMP9 IL1B 16148153 1455154 Chondrocytes and synoviocytes , the resident cells of joint capsule , markedly increase transcription of [MMP-9] in *response* to and TNF-alpha mediated stimulation . Regulation MMP9 IL1B 16939904 1609341 To investigate the *role* of in regulating the expressions of [matrix metalloproteinase-9 (MMP-9)] and tissue inhibitor of matrix metalloproteinase-3 ( TIMP-3 ) in cultured human endometrial cells of the mid-secretory phase . Regulation MMP9 IL1B 17890880 1811206 TNF-alpha and mediated *regulation* of [MMP-9] and TIMP-1 in human glomerular mesangial cells . Regulation MMP9 IL1B 18400000 1899469 In contrast , Porphyromanas gingivalis ATCC 33277 supernatants , Escherichia coli lipopolysacchride and exhibited no stimulatory *effects* on [MMP-9] production in hPDL cells . Regulation MMP9 IL1B 18824875 1981583 Therefore we examined the potential role of nitric oxide ( NO ) in the *regulation* of [MMP-9] and TIMP-1 by tumour necrosis factor-alpha (TNF-alpha) and using the human mesangial cell line ( HMCL ) . Regulation MMP9 IL1B 19107653 2018841 Inhibition of histone deacetylases antagonized FGF2 and *effects* on [MMP] expression in human articular chondrocytes . Regulation MMP9 IL1B 21344389 2480474 These findings establish CEBPB as a critical intermediate for *dependent* [MMP] gene activation and assign specific roles for the ERK and RSK kinases in this pathway . Regulation MMP9 IL1B 8006017 258037 Increasing ( by lipopolysaccharide treatment ) or decreasing ( by glucocorticoid treatment ) production had parallel *effects* on [MMP-9] secretion , metalloproteinase activity , and invasion . Regulation MMP9 IL1B 8587235 341510 After 24 hours , isolated glomeruli containing transfectants exhibited TGF-beta bioactivity , a reduced mitogenic response , and repressed expression of [MMP-9] in *response* to . Regulation MMP9 IL1B 8769830 379122 Glomerular mesangial cells express [matrix metalloproteinase-9 (MMP-9)] in *response* to the proinflammatory cytokine . Regulation MMP9 IL1B 8831705 385819 Compared to mock transfectants , the vector cells showed blunted expression of [gelatinase B] , stromelysin and monocyte chemoattractant protein-1 in *response* to . Regulation MMP9 IL1B 8831705 385821 Compared to either unmodified or mock cell containing glomeruli , the glomeruli transferred with vector cells showed repressed expression of [gelatinase B] in *response* to . Regulation MMP9 IL1B 8892653 392150 TNF-alpha and *regulated* the expression of [92-kDa gelatinase] by monocyte derived macrophages at the pretranslational level . Regulation MMP9 IL1B 8906257 394150 Type I collagen gene expression , and abrogated the *effect* of on [MMP] expression . Regulation MMP9 IL1B 9357863 462082 Divergent regulation of [92-kDa gelatinase] and TIMP-1 by HBECs in *response* to and TNF-alpha . Regulation MMP9 IL1B 9727371 529934 The present study examines the *effect* of transforming growth factor-beta1 ( TGF-beta1 ) and on the regulation of gelatinase A , [gelatinase B] , tissue inhibitor of metalloproteinase-I ( TIMP-I ) and TIMP-II in human glomerular epithelial cells ( GEC ) . Regulation MMP9 MAP2K6 19833163 2196363 inhibitor slightly prevented cell growth inhibition , cell death and GSH depletion by PG. JNK inhibitor did not *affect* cell growth , cell death , [MMP] ( DeltaPsi ( m ) ) loss , ROS level and GSH deletion in PG-treated Calu-6 cells but p38 inhibitor mildly enhanced MMP ( DeltaPsi ( m ) ) loss , O ( 2 ) ( - ) level and GSH depletion in these cells . Regulation MMP9 MAP2K6 19924065 2167057 Finally , we investigated the *effect* of adenoviral constitutively active ( CA ) <-MEK> and CA-Akt on [MMP-9] expression . Regulation MMP9 MAP2K6 21167264 2390792 *Effects* of DNMT and inhibitors on the expression of RECK , [MMP-9] , -2 , uPA and VEGF in response to arsenite stimulation in human uroepithelial cells . Regulation MMP9 MMP28 14514237 1146906 In this study , we evaluated the cytotoxicity of hydroxamic acid based inhibitors ( ONO-4817 , ONO-MI1-514 , and ONO-MI1-570 ) , and their inhibitory *effects* on [MMP-2 and -9] activities and growth of Porphyromonas gingivalis . Regulation MMP9 MMP28 17673717 1788189 *Effects* of minocycline , a nonspecific inhibitor , and pyrrolidine dithiocarbamate , an upstream regulator of MMPs , on [MMP-9] activity and thereby the degree of ICH were also tested . Regulation MMP9 MMP7 14514237 1146921 In this study , we evaluated the cytotoxicity of hydroxamic acid based inhibitors ( ONO-4817 , ONO-MI1-514 , and ONO-MI1-570 ) , and their inhibitory *effects* on [MMP-2 and -9] activities and growth of Porphyromonas gingivalis . Regulation MMP9 MMP7 17673717 1788204 *Effects* of minocycline , a nonspecific inhibitor , and pyrrolidine dithiocarbamate , an upstream regulator of MMPs , on [MMP-9] activity and thereby the degree of ICH were also tested . Regulation MMP9 OLFM4 23161172 2707583 For further insight into the mechanisms underlying OLFM4 mediated suppression of tumor progression , we examined the *effect* of on the expression of integrin and [matrix metalloproteinase (MMP)] , both of which are involved in tumor progression . Regulation MMP9 PECAM1 11781384 900330 *Regulation* of [gelatinase B] in human monocytic and endothelial cells by ligation and its modulation by interferon-beta . Regulation MMP9 PLAT 16051896 1447808 The *effects* of ( 10 mg/kg IV ) on ischemic brain [MMP-9] levels were assessed by zymography . Regulation MMP9 PLAT 16978586 1616880 Moreover , lack of activity attenuates migrating ability of macrophages and *affects* [MMP-9] expression and activity in macrophages in vitro . Regulation MMP9 PLAT 18716863 2028249 These results indicate that activity may *regulate* the [MMP-9] activity in injury nerve post-CCI . Regulation MMP9 PLAT 19672275 2162796 Microglial low-density lipoprotein receptor related protein 1 mediates the *effect* of on [matrix metalloproteinase-9] activity in the ischemic brain . Regulation MMP9 PLAT 23565108 2767714 Reactive oxygen species can enhance the *effects* of on [MMP] activation through the loss of caveolin-1 (cav-1) , a protein encoded in the cav-1 gene that serves as a critical determinant of BBB permeability . Regulation MMP9 PLAU 12117412 997491 In the present study , the *role* of in regulating [matrix metalloproteinase (MMP)] expression and release by the monocyte cell line THP-1 was investigated . Regulation MMP9 PLAU 21075828 2376643 Our data suggest that the intrinsic developmental program predominantly regulates PLAU expression during implantation , and that could be *responsible* for activation of [MMP9] , leading to localized matrix proteolysis as trophoblast invasion commences . Regulation MMP9 TGM2 18809380 1976251 The decreased mRNA levels of MMP-9 and the results of a promoter assay revealed that may be *involved* in [MMP-9] transcription . Regulation MMP9 TNF 10329260 613154 Neither nor transforming growth factor-beta , both thought to have significant roles in the control of placentation , *affected* [MMP] secretion . Regulation MMP9 TNF 10967046 728286 *Regulation* of collagenase , stromelysin , and [gelatinase B] in human conjunctival and conjunctivochalasis fibroblasts by interleukin-1beta and . Regulation MMP9 TNF 10996723 733897 *Effects* of and interferon-gamma on expressions of [matrix metalloproteinase-2 and -9] in human bladder cancer cells . Regulation MMP9 TNF 10996723 733901 We have investigated the *effects* of and interferon ( INF-gamma ) , the potent Bacillus Calmette-Guerin ( BCG ) -induced cytokines on the production of MMP-2 , [MMP-9] , TIMP-1 , TIMP-2 and MT1-MMP in high grade human bladder cancer cell lines , T-24 , J-82 and HT-1376 cell lines . Regulation MMP9 TNF 11014232 736348 Together , these data suggest that *regulated* [MMP-9] may play a role in the controlled invasion of the fad pad that occurs during normal mammary gland development and that misregulation of MMP-9 may contribute to the invasiveness of breast cancer . Regulation MMP9 TNF 11500442 847061 In conclusion , we show that mycobacterial infection induces [MMP-9] activity both in vitro and in vivo and that this is *regulated* by , IL-18 , and IFN-gamma . Regulation MMP9 TNF 11747375 889296 *Effects* of pseudomonal virulence factors [ elastase , alkaline protease , exotoxin A and lipopolysaccharide (LPS) ] , and interleukin (IL)-1beta on [MMP] induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ) , zymography and immunoblotting . Regulation MMP9 TNF 12105194 984535 Interferons ( IFNs ) inhibit [MMP-9] activation in *response* to , and the latter activates the MMP-9 gene through NF-kappaB . Regulation MMP9 TNF 12113550 963853 This study used reverse transcriptase-PCR to investigate the *effects* of on [matrix metalloproteinase (MMP)] mRNA expression in human periodontal ligament fibroblasts . Regulation MMP9 TNF 12789230 1097424 These results suggest that [MMP] inhibitors *regulate* inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta , IL-4 , and expression . Regulation MMP9 TNF 13679081 1140273 [Matrix metalloproteinase-9 (MMP-9)] expression was also increased in *response* to in aged MASMC , as evidenced by zymography and immunoblot analysis . Regulation MMP9 TNF 13679081 1140275 In addition , the transcription factors NF-kappaB and AP-1 that are involved in the [MMP-9] regulation of aged MASMC in *response* to were identified by means of mutation analysis and gel shift assays . Regulation MMP9 TNF 14724072 1197980 Zymography , immunoblot , and northern blot analysis showed that [MMP-9] expression is significantly reduced in *response* to stimulation with increasing in vitro age . Regulation MMP9 TNF 14755547 1205649 In addition , the transcription factors NF-kappaB and AP-1 that are involved in the Ras/ERK mediated control of [MMP-9] regulation on HASMC in *response* to have now been identified . Regulation MMP9 TNF 14984207 1214668 Furthermore , PTEN expression strongly decreased [MMP-9] promoter activity in *response* to . Regulation MMP9 TNF 15175338 1273493 Furthermore , GD3 synthase gene expression strongly decreased [MMP-9] promoter activity in *response* to . Regulation MMP9 TNF 15273742 1296420 *regulates* epithelial expression of [MMP-9] and integrin alphavbeta6 during tumour promotion . Regulation MMP9 TNF 15273742 1296422 Collectively , these data suggest that [MMP-9] regulates keratinocyte migration in a *dependent* manner . Regulation MMP9 TNF 15273742 1296424 These data illustrate a novel TNF-alpha dependent mechanism for the control of alphavbeta6 expression and suggest one pathway for *regulation* of [MMP-9] . Regulation MMP9 TNF 15458430 1301537 The differential *effects* of and IL-1beta on proximal tubular [MMP-9] and TIMP-1 expression are mediated through the TNF-RI , the IL-1-RI and the different signaling pathways of PKC , ERK1/2 , and p38 MAPK . Regulation MMP9 TNF 15513534 1328331 The addition of FP caused significant suppression of [MMP-2 and -9] production from nasal polyp fibroblasts in *response* to stimulation . Regulation MMP9 TNF 15537504 1336499 This study investigated the *effect* of on human cardiac myofibroblast proliferation , invasion and [MMP-9] secretion , and determined whether these properties were modulated by simvastatin . Regulation MMP9 TNF 15663564 1350408 We evaluated whether fexofenadine hydrochloride ( FEX ) , the carboxylic acid metabolite of terfenadine with selective H ( 1 ) -receptor antagonist activity , could inhibit [MMP] production from nasal fibroblasts ( NFs ) in *response* to stimulation in vitro . Regulation MMP9 TNF 15723721 1376758 Similarly , pharmacological inhibition of signaling clearly suppressed the *dependent* [MMP-9] secretion . Regulation MMP9 TNF 16106101 1445028 We evaluated whether tranilast ( TR ) could inhibit [MMP] production from nasal fibroblasts in *response* to stimulation in vitro . Regulation MMP9 TNF 16106101 1445032 TR at more than 5 x 10 ( -5 ) M inhibited the production of MMP-2 and [MMP-9] from NF in *response* to stimulation , whereas TIMP-1 and TIMP-2 production was scarcely affected . Regulation MMP9 TNF 16140265 1454779 Since *plays* a crucial role in the regulation of [MMP-9] expression , the development of molecules capable of modulating TNF-alpha induced signaling is an issue of concern . Regulation MMP9 TNF 16148153 1455153 Chondrocytes and synoviocytes , the resident cells of joint capsule , markedly increase transcription of [MMP-9] in *response* to IL-1beta- and mediated stimulation . Regulation MMP9 TNF 16816114 1580955 In addition , we found that treatment with antioxidants reversed the decreased [matrix metalloproteinase-9 (MMP-9)] expression in *response* to as determined by zymography and immunoblot in GD3 synthase gene transfectants . Regulation MMP9 TNF 16818654 1581256 We investigated the role of focal adhesion kinase ( FAK ) in *dependent* production of [MMP-9] in CCKS1 and FAK-null mouse fibroblast cells . Regulation MMP9 TNF 16818654 1581259 Conditional expression of wild-type FAK in FAK-null cells restored the *dependent* production of [MMP-9] . Regulation MMP9 TNF 16818654 1581261 In addition , small interfering RNA against FAK drastically suppressed the *dependent* production of [MMP-9] and inhibited the TNF-alpha dependent invasion of CCKS1 . Regulation MMP9 TNF 16818654 1581263 Taken together , our results suggest the pivotal role of FAK in *dependent* production of [MMP-9] and subsequent activation of tumor invasion . Regulation MMP9 TNF 16905636 1672860 [MMP] production is largely *dependent* , further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke induced lung disease . Regulation MMP9 TNF 17062332 1637242 Fenofibrate significantly inhibited the stimulatory *effect* of on MMP-2 and [MMP-9] activities in HUVECs . Regulation MMP9 TNF 17186550 1724632 Our results suggest that *dependent* induction of [MMP-9] gene expression is tightly regulated by oscillatory/cumulative activation of NFkappaB and that 5-Fu stimulates NFkappaB and RKO CRC cell survival through induction of IKK activity . Regulation MMP9 TNF 17242183 1710040 In this study , we show that FoxO4 activates transcription of the [MMP9] gene in *response* to signaling . Regulation MMP9 TNF 17357478 1665116 To study the *effects* of on [matrix metalloproteinase (MMP)-9] expression and activity in alveolar macrophages ( AM ) and to investigate the role of NF-kappaB in the induction , AM were collected from bronchoalveolar lavage fluid ( BALF ) of healthy subjects and patients with chronic obstructive pulmonary disease ( COPD ) . Regulation MMP9 TNF 17570325 1753754 Moreover , magnolol treatment strongly decreased [MMP-9] promoter activity in *response* to . Regulation MMP9 TNF 18277865 1872205 The *effect* of on membrane type [(MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MMP9 TNF 18449943 1932939 Using this system , we have shown that astrocytes and microglia express distinct sets of MMP genes and that microglia , not astrocytes , are the major source of [MMP-9] in *response* to LPS or . Regulation MMP9 TNF 18556801 1940716 In vitro , PPARgamma agonists reduced IL-8 and [MMP-9] release from airway epithelial cells in *response* to PAO1 or stimulation . Regulation MMP9 TNF 18824875 1981582 Therefore we examined the potential role of nitric oxide ( NO ) in the *regulation* of [MMP-9] and TIMP-1 by and interleukin-1 beta (IL-1 beta) using the human mesangial cell line ( HMCL ) . Regulation MMP9 TNF 19281093 2007654 We evaluated whether tiotropium bromide hydrate ( TBH ) , a M3 muscarinic receptor antagonist , could inhibit [MMP] production from lung fibroblasts ( LFs ) in *response* to stimulation . Regulation MMP9 TNF 19306950 2080124 [Matrix metalloproteinase-9 (MMP-9)] expression and migration were also increased in *response* to in SHR derived cells . Regulation MMP9 TNF 20332214 2238136 This report establishes that Egr-1 is essential for [MMP-9] transcription in *response* to within the tumor microenvironment . Regulation MMP9 TNF 20617373 2418892 Expression of interleukin (IL)-6 , IL-8 , and were substantially increased and *involved* in macrophage induced VEGF and [MMP-9] mRNA expression in MCF-7 cells . Regulation MMP9 TNF 22321809 2576052 Potent synergistic *effect* of IL-3 and on [matrix metalloproteinase 9] generation by human eosinophils . Regulation MMP9 TNF 22321809 2576060 Remarkable synergistic synthesis of [MMP-9] ( ng/ml levels ) occurred in *response* to plus IL-3 , GM-CSF or IL-5 , in the order of IL-3 > GM-CSF > IL-5 . Regulation MMP9 TNF 22321809 2576063 Thus , the synergistic *regulation* of eosinophil [MMP-9] by IL-3 plus likely involves cooperative interaction of multiple transcription factors downstream from ERK , p38 , and NF-?B activation as well as post-transcriptional regulation of MMP-9 mRNA stabilization . Regulation MMP9 TNF 22572236 2603574 *Involvement* of and MAPK pathway in the intramammary [MMP-9] release via degranulation of cow neutrophils during acute mammary gland involution . Regulation MMP9 TNF 22572236 2603576 Also , cultures of bovine peripheral neutrophils were conducted to examine the mode of short-term [MMP-9] secretion in *response* to stimulation and the blocking effects of TNF-a antibody and inhibitors of MAPK pathways . Regulation MMP9 TNF 22572236 2603578 In vitro studies indicate linear increase of short-term [MMP-9] release in *response* to stimulation in dosages between 0.1 and 10 ng/ml . Regulation MMP9 TNF 22684781 2633458 These findings may suggest that OPN and [MMP-9] may be *regulated* by , indicating a possible role in the pathogenesis of psoriasis . Regulation MMP9 TNF 23224948 2731484 In this study , we investigated the molecular mechanism of *regulated* [MMP-9] expression . Regulation MMP9 TNF 23341882 2733875 PDTC significantly inhibited the expression of [MMP9] and the phosphorylation of I?Ba , as well as the expression of phosphorylation p65 protein in *response* to ( p < 0.05 ) . Regulation MMP9 TNF 23417988 2843485 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by and selectively *control* TNF-a mediated [MMP] expression via the NF-?B pathway . Regulation MMP9 TNF 23435195 2771332 It has been reported that , a *regulator* of [MMP-9] , can induce invasion in human renal carcinoma cells . Regulation MMP9 TNF 24085323 2857999 In chondrosarcoma cells , had a stimulatory *effect* on [MMP-9] and insignificant effect on MMP-2 and interleukin (IL)-1ß stimulated MMP-9 and MMP-2 . Regulation MMP9 TNF 24085323 2858001 In fibrosarcoma and liposarcoma cells , had a profound stimulatory *effect* on [MMP-9] , but no effect on MMP-2 and in synovial sarcoma an inhibitory effect on MMP-2 and no effect on MMP-9 . Regulation MMP9 TNF 7802656 284526 In contrast , in uninfected cells down *regulated* [gelatinase B] mRNA level , without affecting the gelatinase A . Regulation MMP9 TNF 8204888 261131 Thus , [MMP-9] secretion may be *regulated* by not only in a paracrine but also in an autocrine fashion . Regulation MMP9 TNF 8892653 392149 and IL-1beta *regulated* the expression of [92-kDa gelatinase] by monocyte derived macrophages at the pretranslational level . Regulation MMP9 TNF 9130458 426873 This study examined the *role* of IFN-gamma and ( + ) in the regulation of the matrix metalloproteinases , MMP-2 ( 72 kD gelatinase A ) and [MMP-9] ( 92 kD gelatinase B ) . Regulation MMP9 TNF 9357863 462081 Divergent regulation of [92-kDa gelatinase] and TIMP-1 by HBECs in *response* to IL-1beta and . Regulation MMP9 TNF 9622599 511279 Taken together , these data suggest that IL-1 , and TGFbeta2 tightly *regulate* [Gel B] secretion in glioma cells , an enzyme which is believed to play an important role in the local invasion of brain tissue by tumor cells . Regulation MMP9 TNF 9917505 587599 Transcriptional *regulation* of [MMP-9] expression in stromal cells of human giant cell tumor of bone by . Regulation MMP9 TNF 9917505 587600 In order to confirm this we examined the *role* of on the induction of [MMP-9] expression in bone GCT stromal cells . Regulation MNAT1 NES 21346193 2420580 *regulated* the cleavage of the Cdk5 activator protein [p35] to its degradation-resistant form , p25 . Regulation MOCOS TNF 22819042 2634989 Unlike normal cells , [MCs] expressing mutant Nlrp3 produced IL-1ß in *response* to lipopolysaccharide or . Regulation MOCOS TNF 2844896 98603 An unchanged transcriptional activity of the LTR controlled v-mos and c-myc genes , but a decreased half-life of oncogene-specific mRNA suggests that primarily *affects* stability of [v-mos] and c-myc RNA without influencing the activity of retroviral promoters . Regulation MOCS1 COQ2 19331131 2052628 The aim of this study was to investigate antioxidant *effects* of quercetin and on [mini organ cultures (MOCs)] of human nasal mucosa . Regulation MOCS1 COQ3 19331131 2052624 The aim of this study was to investigate antioxidant *effects* of quercetin and on [mini organ cultures (MOCs)] of human nasal mucosa . Regulation MOCS1 COQ4 19331131 2052625 The aim of this study was to investigate antioxidant *effects* of quercetin and on [mini organ cultures (MOCs)] of human nasal mucosa . Regulation MOCS1 COQ5 19331131 2052630 The aim of this study was to investigate antioxidant *effects* of quercetin and on [mini organ cultures (MOCs)] of human nasal mucosa . Regulation MOCS1 COQ6 19331131 2052626 The aim of this study was to investigate antioxidant *effects* of quercetin and on [mini organ cultures (MOCs)] of human nasal mucosa . Regulation MOCS1 COQ7 19331131 2052627 The aim of this study was to investigate antioxidant *effects* of quercetin and on [mini organ cultures (MOCs)] of human nasal mucosa . Regulation MOCS1 COQ9 19331131 2052629 The aim of this study was to investigate antioxidant *effects* of quercetin and on [mini organ cultures (MOCs)] of human nasal mucosa . Regulation MOK EPHB2 12935895 1132877 These data suggest that may *play* a role in [RAGE] signaling through direct interaction with RAGE . Regulation MOK S100B 18649404 1979362 In the current study , we examined the binding of the receptor ( RAGE ) on microglial cells and the developmental *effects* of the antioxidant vitamin E on microglial activation and the upregulation of [RAGE] in an S100B over expressing mouse model of pathological aging . Regulation MOK S100B 20672051 2298628 The *regulation* of [RAGE] signaling by is complex and probably involves other ligands including the amyloid beta peptide ( Abeta ) , the Advanced Glycation Endproducts ( AGEs ) , or transtheyretin . Regulation MOK S100B 21423669 2405936 Thus , the spatiotemporal *regulation* of TLRs and [RAGE] by provides evidence for an evolving braking circuit in infection whereby an endogenous danger protects against pathogen induced inflammation and a pathogen sensing mechanism resolves danger induced inflammation . Regulation MOK S100B 21570918 2480819 We show that expression of both [RAGE] and S100B are increased during EAMG and the interaction between RAGE and *affected* the Th1/Th2/Th17/Treg cell equilibrium , up-regulate AChR-specific T cell proliferation . Regulation MOS EPHB2 17065147 1654769 Together , these data suggest that Paxillin is an important regulator of the positive feedback *effects* of signaling on [MOS] protein expression . Regulation MOS MAP2K6 17065147 1654775 Together , these data suggest that Paxillin is an important regulator of the positive feedback *effects* of signaling on [MOS] protein expression . Regulation MPI TNF 22499423 2583760 The PM-susceptibility to infection was accessed by the [PM-infection index (PMI)] at 24 , 72 h and by the mean of these rates ( FPMI ) , as well as by the , IL-12 ( Capture ELISA ) and Nitric oxide ( NO ) *responses* ( Griess method ) . Regulation MPO ARSA 18703751 1968070 [MPO] activity was decreased significantly in *response* to monotherapy with 5-ASA and each of the antioxidants plus <5-ASA> when compared to TNBS . Regulation MPO ITGB2 10409195 629872 however , had no *effect* on intestinal or hepatic F ( 2 ) -isoprostane levels or on pulmonary [MPO] activity . Regulation MPO TNF 10699463 672116 *Role* of in regulation of [myeloperoxidase] expression in irradiated HL60 promyelocytic cells . Regulation MPO TNF 16269189 1502331 Control , but not capsaicin pretreated rats ( to deplete sensory nerves ) , exhibited a marked increase in [MPO] activity in *response* to . Regulation MPO TNF 16997860 1647247 In the literature , the requirement of TNF priming has been attributed to an *effect* of on the expression of PR3 or [MPO] on the cell surface . Regulation MPO TNF 1703177 151329 We investigated the stability of LF and MPO mRNA and the *effects* of purified recombinant human on LF and [MPO] levels in normal human bone marrow . Regulation MPP1 TNF 11522182 852740 To determine whether TNFR p55 was involved in amplification of cellular response to TNF-alpha by HIV-1 Tat , we investigated the *effect* of on TNFR [p55] expression in the tat transfected cells . Regulation MRAP TNF 10717805 676650 The results of differential linkage disequilibrium with HLA-B27 subtypes suggest that [B27] itself remains the primary gene for AS susceptibility , and and MICA are not *involved* in the pathogenesis of the disease . Regulation MRC1 CLU 16297852 1502747 The *role* of and Bcl-2 on C ( 2 ) -ceramide induced apoptosis of embryonic human diploid fibroblasts , [MRC-5] and immortalized adult skin keratinocytes , HaCaT was investigated . Regulation MRC2 CLU 16297852 1502745 The *role* of and Bcl-2 on C ( 2 ) -ceramide induced apoptosis of embryonic human diploid fibroblasts , [MRC-5] and immortalized adult skin keratinocytes , HaCaT was investigated . Regulation MRT10 CCND1 20179200 2215860 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Regulation MRT11 CCND1 20179200 2215863 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Regulation MRT12 CCND1 20179200 2215866 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Regulation MRT17 CCND1 20179200 2215848 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Regulation MRT18 CCND1 20179200 2215869 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Regulation MRT19 CCND1 20179200 2215872 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Regulation MRT20 CCND1 20179200 2215875 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Regulation MRT21 CCND1 20179200 2215878 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Regulation MRT22 CCND1 20179200 2215881 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Regulation MRT23 CCND1 20179200 2215884 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Regulation MRT24 CCND1 20179200 2215887 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Regulation MRT25 CCND1 20179200 2215890 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Regulation MRT26 CCND1 20179200 2215893 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Regulation MRT27 CCND1 20179200 2215896 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Regulation MRT28 CCND1 20179200 2215899 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Regulation MRT4 CCND1 20179200 2215845 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Regulation MRT5 CCND1 20179200 2215851 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Regulation MRT8 CCND1 20179200 2215854 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Regulation MRT9 CCND1 20179200 2215857 Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A) , p21 ( CIP1/WAF1 ) , and playing key *roles* in [MRT] cell growth control . Regulation MRXS5 IL1B 11717138 881888 Results of studies designed to enrich or deplete nitric oxide strongly suggest that the stimulatory *effect* of on ovarian [PGS-2] expression is independent of nitric oxide . Regulation MRXS5 IL1B 11717138 881889 Utilization of a series of agents designed to simulate or enhance transduction via the sphingomyelin ceramide cycle suggests that the long-term stimulatory *effect* of on ovarian [PGS-2] gene expression is independent of ceramide . Regulation MRXS5 IL1B 11717138 881892 Taken together , these findings suggest that the stimulatory *effect* of on [PGS-2] expression is 1 ) independent of nitric oxide as well as ceramide , 2 ) dependent on prostaglandin E ( 2 ) , 3 ) contingent on de novo protein biosynthesis , and 4 ) accounted for by both increased transcription and message stabilization . Regulation MRXS5 IL1B 1641074 194782 In the present study , we have characterized the production of PGs from the rat hypothalamus in vitro , and investigated the *effects* of and IL-6 , as well as the neurotransmitters norepinephrine , acetylcholine and 5-hydroxytryptamine , on the acute release of [PGs] , using a well validated acute hypothalamic incubation system . Regulation MRXS5 SLCO2A1 14687530 1179586 The decrease of PGE ( 2 ) level and the increase of TXA ( 2 ) level in the intestinal mucosa of scalded rats might be involved in rat mucosal injury , and *played* an important role in the regulation of [PGs] levels . Regulation MRXS5 TNF 10570310 568425 Indeed , dPGJ2 blocked adhesion of neutrophils to fibrinogen in *response* to or LPS with an IC50 of 3-5 micro+dPGJ2 was more potent at inhibiting the adhesion dependent oxidative burst than several other [PGs] tested . Regulation MRXS5 TNF 11162356 782138 These cells exhibit many of the properties of villous or extravillous trophoblasts and produce large amounts of [PGs] in *response* to . Regulation MS CD14 17046070 1649383 The aim of this study was to evaluate a possible *role* of soluble ( sCD14 ) in [multiple sclerosis (MS)] . Regulation MS CLU 7730444 302331 Thus , TGF-beta 1 and heterotypic cell interactions influence clusterin expression by astrocytes and may be important to the *role* of in [multiple sclerosis] , AIDS , and Alzheimer 's disease . Regulation MS TLR7 19837184 2216983 An increasing body of circumstantial evidence implicates a *role* of signalling in systemic lupus erythematosus ( SLE ) , atherosclerosis , asthma , type 1 diabetes , [multiple sclerosis] , bowl inflammation and rheumatoid arthritis ( RA ) . Regulation MS TNF 10652446 663193 The precise *role* of in [multiple sclerosis (MS)] is still controversial . Regulation MS4A1 TNF 10891891 711280 This study was conducted to determine the *effect* of ( in vitro ) on [CD20] expression on cells from patients with B-CLL . Regulation MS4A1 TNF 11801463 902538 Additionally , the *effect* of interleukin (IL)-2 , IL-4 , IL-6 , IL-13 , granulocyte/macrophage colony stimulating factor ( GM-CSF ) and on expression of [CD20] molecules per cell was determined . Regulation MSC ANGPT1 18565279 1929492 The aim of the present study was to investigate the protective *effect* of signaling on [MSC] against serum deprivation and hypoxia induced apoptosis , and to determine the possible mechanisms . Regulation MSC ANGPT1 18565279 1929499 The protective *effect* of on [MSC] was dose dependent and peaked at 50 microg/L ; Regulation MSC EFNB1 23711177 2843769 Taken together , these observations suggest that interactions *play* an important role in mediating human [MSC] inhibition of activated T cells . Regulation MSC EPHB2 23711177 2843773 Taken together , these observations suggest that interactions *play* an important role in mediating human [MSC] inhibition of activated T cells . Regulation MSC HBEGF 22819639 2670612 This study investigated the *effects* of on [MSC] in vitro , and whether MSC and HB-EGF can act synergistically to prevent NEC in vivo . Regulation MSC TLR7 24123639 2896488 The aim of this study was to investigate the *effects* of several ligands on the interaction between [MSC] and natural killer ( NK ) cells . Regulation MSC TLR7 24391353 2883843 Subsequently , an overview is provided of the *effects* of DAMP associated activation on [MSC] and their immunomodulative properties after myocardial infarction . Regulation MSC TLR7 24391353 2883853 Elucidating the *effects* of activation on [MSC] could identify new preconditioning strategies which might improve their immunomodulative properties . Regulation MSC TNF 19628074 2112825 Conversely , the *effects* of and/or TGF-alpha on [MSC] VEGF production were significantly decreased , and MEK/ERK activation was negated in cells transfected TNFR2 siRNA . Regulation MSC TNF 20049872 2200695 Although TNF-alpha inhibits the mineralization of osteoblasts , the *effect* of on [mesenchymal stem cells (MSC)] is not clear . Regulation MSC TNF 22931668 2666830 It is concluded that the exhibits different *effects* on immune regulation activity of [MSC] , and its underlying mechanism needs to further investigate . Regulation MSH2 CABP4 8275931 247143 Possible *involvement* of a [ e.g. calmodulin (CaM) ] in the regulation of [MSH] receptor activity has been studied in the M2R mouse melanoma cell line . Regulation MSH3 CABP4 8275931 247148 Possible *involvement* of a [ e.g. calmodulin (CaM) ] in the regulation of [MSH] receptor activity has been studied in the M2R mouse melanoma cell line . Regulation MSH4 CABP4 8275931 247153 Possible *involvement* of a [ e.g. calmodulin (CaM) ] in the regulation of [MSH] receptor activity has been studied in the M2R mouse melanoma cell line . Regulation MSH5 CABP4 8275931 247158 Possible *involvement* of a [ e.g. calmodulin (CaM) ] in the regulation of [MSH] receptor activity has been studied in the M2R mouse melanoma cell line . Regulation MSH6 CABP4 8275931 247163 Possible *involvement* of a [ e.g. calmodulin (CaM) ] in the regulation of [MSH] receptor activity has been studied in the M2R mouse melanoma cell line . Regulation MST1R STK39 15363108 1304075 Due to difficulty with reproducibility of the transformation assay in BEAS-2B cells , we have used more tractable rodent fibroblast models to further study Hyal2 modulation of transforming activity and potential *effects* of Hyal2 on [RON/Stk] activation by its natural ligand , macrophage stimulating protein (MSP) . Regulation MSTN EPHB2 20419100 2246634 [Myostatin] is upregulated following stress in an *dependent* manner and negatively regulates cardiomyocyte growth in culture and in a mouse model . Regulation MSTN EPHB2 20419100 2246635 [Myostatin] is upregulated following cardiomyocyte stress in an *dependent* manner that is associated with increased nuclear translocation and DNA binding activity of MEF-2 . Regulation MSTN FBXO32 22673621 2659018 Therefore , these results highlight the central *role* of in regulating [myostatin] signaling during myogenesis . Regulation MSTN FOXO1 16885393 1672613 Here we examined the *role* of and SMAD transcription factors in regulating [myostatin] gene expression and myoblast differentiation in C ( 2 ) C ( 12 ) myotubes in vitro . Regulation MSTN GPRASP2 24019467 2846072 *Regulation* of GDF-11 and [myostatin] activity by GASP-1 and . Regulation MSTN TNF 19218333 2050175 This study aimed to investigate the expression of myostatin in CHF , the influence of exercise training on myostatin levels , and *regulation* of [myostatin] by . Regulation MSX1 BMP1 15936012 1427444 Lastly , we provide evidence that Prx homeobox genes repress expression of an Msx2 transgene , previously shown to be Bmp4-responsive , revealing a mechanism for differential *regulation* of [Msx1] and Msx2 by signaling . Regulation MSX1 BMP10 15936012 1427452 Lastly , we provide evidence that Prx homeobox genes repress expression of an Msx2 transgene , previously shown to be Bmp4-responsive , revealing a mechanism for differential *regulation* of [Msx1] and Msx2 by signaling . Regulation MSX1 BMP15 15936012 1427445 Lastly , we provide evidence that Prx homeobox genes repress expression of an Msx2 transgene , previously shown to be Bmp4-responsive , revealing a mechanism for differential *regulation* of [Msx1] and Msx2 by signaling . Regulation MSX1 BMP2 15936012 1427446 Lastly , we provide evidence that Prx homeobox genes repress expression of an Msx2 transgene , previously shown to be Bmp4-responsive , revealing a mechanism for differential *regulation* of [Msx1] and Msx2 by signaling . Regulation MSX1 BMP3 15936012 1427447 Lastly , we provide evidence that Prx homeobox genes repress expression of an Msx2 transgene , previously shown to be Bmp4-responsive , revealing a mechanism for differential *regulation* of [Msx1] and Msx2 by signaling . Regulation MSX1 BMP4 15936012 1427448 Lastly , we provide evidence that Prx homeobox genes repress expression of an Msx2 transgene , previously shown to be Bmp4-responsive , revealing a mechanism for differential *regulation* of [Msx1] and Msx2 by signaling . Regulation MSX1 BMP4 9541209 498052 These observations suggest that whereas may be *involved* in activation of [Msx-1] and Msx-2 in the underlying mesenchyme , EGF may regulate events involved in the formation of dental lamina . Regulation MSX1 BMP5 15936012 1427449 Lastly , we provide evidence that Prx homeobox genes repress expression of an Msx2 transgene , previously shown to be Bmp4-responsive , revealing a mechanism for differential *regulation* of [Msx1] and Msx2 by signaling . Regulation MSX1 BMP6 15936012 1427450 Lastly , we provide evidence that Prx homeobox genes repress expression of an Msx2 transgene , previously shown to be Bmp4-responsive , revealing a mechanism for differential *regulation* of [Msx1] and Msx2 by signaling . Regulation MSX1 BMP7 10633853 576656 The *effects* of on the expression of [Msx] genes in lateral chick mandibular mesenchyme , although different from the effects of lateral mandibular epithelium , are similar to the effects of epithelium from the medial region where multiple Bmps are expressed . Regulation MSX1 BMP7 15936012 1427451 Lastly , we provide evidence that Prx homeobox genes repress expression of an Msx2 transgene , previously shown to be Bmp4-responsive , revealing a mechanism for differential *regulation* of [Msx1] and Msx2 by signaling . Regulation MSX1 CISH 7866431 287289 Taken together , both positive and negative regulatory are *involved* in the regulation of the [MSX-1] promoter and coordinate to control the gene expression . Regulation MSX1 FOXE1 21177256 2385663 The [MSX1] and TGF-ß3 up-regulation in *response* to at both transcriptional and translational levels and the recruitment of FOXE1 to specific binding motifs , together with the transactivation of the promoters of these genes , indicate that MSX1 and TGF-ß3 are direct FOXE1 targets . Regulation MSX1 ID1 16028273 1447495 Here , we demonstrate that transcription factors Twist and Snail are downstream targets of FGF signalling , that and Msx2 are downstream targets of BMP signalling , and that [Msx1] is *regulated* by both signalling pathways during tooth and palate development . Regulation MSX1 MSX2 16028273 1447496 Here , we demonstrate that transcription factors Twist and Snail are downstream targets of FGF signalling , that Id1 and are downstream targets of BMP signalling , and that [Msx1] is *regulated* by both signalling pathways during tooth and palate development . Regulation MSX1 PAX3 21932309 2479877 We found that lamprey neural plate border expression of prdm1 is activated by Ap-2 and [Msx] , but is *independent* of and Zic . Regulation MSX1 PAX7 21932309 2479878 We found that lamprey neural plate border expression of prdm1 is activated by Ap-2 and [Msx] , but is *independent* of and Zic . Regulation MSX1 TNF 22685265 2633475 up-regulated Msx2 mRNA 4-fold within 3 h but did not *regulate* [Msx1] . Regulation MSX1 WNT1 15691759 1371432 [Msx1] induces Pax3 and ZicR1 cell autonomously , in turn , Pax3 combined with ZicR1 activates Slug in a *dependent* manner . Regulation MSX1 WNT11 15691759 1371433 [Msx1] induces Pax3 and ZicR1 cell autonomously , in turn , Pax3 combined with ZicR1 activates Slug in a *dependent* manner . Regulation MSX1 WNT16 15691759 1371438 [Msx1] induces Pax3 and ZicR1 cell autonomously , in turn , Pax3 combined with ZicR1 activates Slug in a *dependent* manner . Regulation MSX1 WNT2 15691759 1371434 [Msx1] induces Pax3 and ZicR1 cell autonomously , in turn , Pax3 combined with ZicR1 activates Slug in a *dependent* manner . Regulation MSX1 WNT3 15691759 1371435 [Msx1] induces Pax3 and ZicR1 cell autonomously , in turn , Pax3 combined with ZicR1 activates Slug in a *dependent* manner . Regulation MSX1 WNT4 15691759 1371436 [Msx1] induces Pax3 and ZicR1 cell autonomously , in turn , Pax3 combined with ZicR1 activates Slug in a *dependent* manner . Regulation MSX1 WNT6 15691759 1371437 [Msx1] induces Pax3 and ZicR1 cell autonomously , in turn , Pax3 combined with ZicR1 activates Slug in a *dependent* manner . Regulation MSX1 ZIC1 21932309 2479872 We found that lamprey neural plate border expression of prdm1 is activated by Ap-2 and [Msx] , but is *independent* of Pax3/7 and . Regulation MSX1 ZIC2 21932309 2479873 We found that lamprey neural plate border expression of prdm1 is activated by Ap-2 and [Msx] , but is *independent* of Pax3/7 and . Regulation MSX1 ZIC3 21932309 2479874 We found that lamprey neural plate border expression of prdm1 is activated by Ap-2 and [Msx] , but is *independent* of Pax3/7 and . Regulation MSX1 ZIC4 21932309 2479876 We found that lamprey neural plate border expression of prdm1 is activated by Ap-2 and [Msx] , but is *independent* of Pax3/7 and . Regulation MSX1 ZIC5 21932309 2479875 We found that lamprey neural plate border expression of prdm1 is activated by Ap-2 and [Msx] , but is *independent* of Pax3/7 and . Regulation MSX2 TNF 22685265 2633473 To better understand this biology , we studied *actions* on [Msx2] in aortic myofibroblasts . Regulation MSX2 ZIC2 21932309 2479880 We found that lamprey neural plate border expression of prdm1 is activated by Ap-2 and [Msx] , but is *independent* of Pax3/7 and . Regulation MT-CO2 CA12 11585258 865986 The *effects* of exogenous extracellular on [CO2] excretion in rainbow trout ( Oncorhynchus mykiss ) : role of plasma buffering capacity . Regulation MT-CO2 CA12 11985719 938350 Cyanobacteria possess light dependent [CO2] uptake activity that results in the net hydration of CO2 to HCO3- and may *involve* a protein mediated activity . Regulation MT-CO2 CA12 3115121 77614 We studied the *roles* of gill and erythrocyte in normal [CO2] transfer ( metabolic CO2 elimination ) and in HCO3- excretion during metabolic alkalosis in the resting and swimming dogfish shark , Squalus acanthias . Regulation MT-CO2 CA12 3375606 93285 It is concluded that B. pholis is physiologically well adapted to aerial exposure through adjustments in ventilation and circulation and that erythrocytic *plays* a major role in [CO2] transfer . Regulation MT-CO2 CA12 6772280 11601 The results suggest the need for reinterpretation of some concepts about the *role* of in [CO2] accumulation in the brain . Regulation MT-CO2 CA12 8002517 283891 *Roles* of intra- and extracellular in alveolar-capillary [CO2] equilibration . Regulation MT-CO2 CA12 9227587 443350 An isolated , perfused tail preparation was used to study the *role* of in [CO2] and NH3 transport across the sarcolemma of white muscle in the rainbow trout . Regulation MT-CO3 ABCA12 24950409 2947219 In the cell-free assay significantly inhibited phosphoinositide 3-kinase (PI3K) mediated phosphorylation of Akt1 at Ser473 , but [Li2CO3] did not *affect* PI3K mediated PI ( 3,4,5 ) P3 production and 3-phosphoinositide dependent protein kinase 1 ( PDK1 ) -mediated phosphorylation of Akt1 at Thr308 . Regulation MT1JP TNF 18277865 1872206 The *effect* of on [membrane type (MT)1-MMP] , an activator of MMP-2 , was also assessed . Regulation MT3 IL1B 10537052 562958 *Regulation* of [growth inhibitory factor] expression by epidermal growth factor and in cultured rat astrocytes . Regulation MT3 TNF 1570401 187161 *Effect* of , which is supposed to be one of the mediators responsible for endotoxin , on [metallothionein (MT)] synthesis was determined in various tissues of rats . Regulation MT3 TNF 7640344 317846 *Regulation* of [metallothionein] gene expression by and IFN-beta in human fibroblasts . Regulation MT3 TNF 9675420 520346 Interleukin-6 and tumor necrosis factor-alpha type 1 receptor deficient mice reveal a *role* of IL-6 and on brain [metallothionein-I] and -III regulation . Regulation MT3 TNF 9675420 520348 In this report we have studied the putative *role* of IL-6 and on the regulation of brain MT-I and [MT-III] , by using mice carrying a null mutation in the IL-6 or the TNF-alpha type 1 receptor genes or both . Regulation MT4 TNF 1570401 187160 *Effect* of , which is supposed to be one of the mediators responsible for endotoxin , on [metallothionein (MT)] synthesis was determined in various tissues of rats . Regulation MT4 TNF 7640344 317844 *Regulation* of [metallothionein] gene expression by and IFN-beta in human fibroblasts . Regulation MT4 TNF 9675420 520344 Interleukin-6 and tumor necrosis factor-alpha type 1 receptor deficient mice reveal a *role* of IL-6 and on brain [metallothionein-I] and -III regulation . Regulation MTOR CAPN8 23467348 2750031 BDNF treatment rapidly reduced levels of hamartin and tuberin , negative regulators of [mTOR] , in a *dependent* manner . Regulation MTOR CCND1 19225536 2054556 As [mTOR signaling] is activated in MCL and may *control* levels , we show that p53 activation may downregulate the AKT/mTOR pathway through a mechanism involving AMP kinase (AMPK) . Regulation MTOR EPHB2 15757502 1409725 However , it remained unclear whether activation was required and which downstream components were *involved* in activating [mTOR] and protein synthesis . Regulation MTOR EPHB2 16816403 1606229 Treatment with PGF2alpha did not increase AKT phosphorylation but increased the phosphorylation of and the tumor suppressor protein tuberous sclerosis complex 2 (TSC2) , an upstream *regulator* of [mTOR] . Regulation MTOR EPHB2 17255101 1718058 Similar data indicated that [mTOR] is *regulated* by both phosphatidylinositol 3-kinase/Akt and . Regulation MTOR EPHB2 23296986 2752470 [mTOR] kinase phosphorylation was *independent* of and Akt in primary cultures . Regulation MTOR EPHB2 23395818 2775964 In this study , we demonstrate that [mTOR] activation in CML CD34 ( + ) progenitor cells is *dependent* in chronic phase of the disease and ERK independent in blast crisis . Regulation MTOR ETV7 18160036 1838612 While Tel2 deletion did not alter PIKK mRNA levels , in vivo pulse labeling experiments showed that *controls* the stability of ATM and [mTOR] . Regulation MTOR FOXO1 23116773 2717458 Akt signaling can control skeletal muscle mass through [mTOR] regulation of protein synthesis and *regulation* of protein degradation , and this pathway has been previously identified as a target of androgen signaling . Regulation MTOR MAP2K6 21659537 2459586 Previous work indicated that [mTORC1] activation by the phorbol ester PMA ( phorbol 12-myristate 13-acetate ) depends upon PKCs and may *involve* . Regulation MTOR PADI3 22605338 2632271 Anticancer inhibitors *regulate* the autophagy flux and the [mammalian target of rapamycin] complex 1 activity . Regulation MTOR PDE4B 21742807 2500164 Finally , we used primary DLBCL samples to confirm the clinical relevance and biomarker potential of [AKT/mTOR] *regulation* by . Regulation MTOR TF 23102618 2695260 Here we report that the [mammalian target of rapamycin (mTOR)] *regulates* iron homeostasis by modulating stability and altering cellular iron flux . Regulation MTOR TNF 12714600 1100557 Phosphorylation of Akt and the [mammalian target of rapamycin] ( but not extracellular regulated kinase or PKCzeta ) in *response* to was inhibited by aspirin treatment . Regulation MUC1 CD14 7536782 300308 Our results also suggest that , in [P-PEM] , in contrast to J774.1 cells and T-PEM , neither PKC nor is *involved* in the LPS induced activation and suppression of TNF-alpha gene expression . Regulation MUC1 EPHB2 16983494 1617466 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Regulation MUC1 EPHB2 17237423 1690042 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Regulation MUC1 GPR115 15527548 1331704 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC1 GPR132 15527548 1331693 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC1 GPR87 15527548 1331773 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC1 HES2 20962044 2348475 Here we demonstrate that interactions among PR isoforms and cytokine activated transcription factors cooperatively *regulate* [MUC1] expression in a human uterine epithelial cell line , . Regulation MUC1 IL1B 10728932 579472 *Effects* of TNF-alpha and on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC1 IL1B 12869928 1112262 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Regulation MUC1 IL1B 14527933 1185866 *Regulation* of MUC5AC [mucin] secretion and airway surface liquid metabolism by in human bronchial epithelia . Regulation MUC1 RARB 10024510 590868 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Regulation MUC1 SPHK1 19835973 2203031 *regulates* [mucin] production via ERK phosphorylation . Regulation MUC1 SPHK1 19835973 2203113 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Regulation MUC1 TNF 10030839 591856 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Regulation MUC1 TNF 10728932 579471 *Effects* of and IL-1 beta on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC1 TNF 11475334 841821 The *effects* of IL-4 , IL-13 , IL-1beta , IL-8 and on 15-LO isoenzyme mRNA and protein expression , total 15-LO enzyme activity and [mucin] secretion were examined in cultures of normal human bronchial epithelial cells . Regulation MUC1 TNF 1748477 172084 The *effects* of on the FC gamma IBS and [mucin] production could not be attributed to a decreased proliferative rate of the cells , as the cells ' incorporation of 5-bromo-2'-deoxyuridine was unaffected . Regulation MUC1 TNF 7842630 286500 *Effect* of interferon-gamma and on MUC1 [mucin] expression in ovarian carcinoma cell lines . Regulation MUC1 TNF 7842630 286517 had little *effect* on [MUC1] expression , but one or five days exposure to IFN-gamma significantly increased MUC1 expression ( p < 0.01 ) in all cell lines including the two cell lines that initially showed little or no expression . Regulation MUC1 TP63 24895124 2951936 Furthermore , inhibition of mucin-type O-linked glycosylation suppressed the *effect* of on increasing [mucin] production and protecting intestinal epithelial cells from TNF induced apoptosis in colon organ culture . Regulation MUC12 EPHB2 16983494 1617468 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Regulation MUC12 EPHB2 17237423 1690044 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Regulation MUC12 GPR115 15527548 1331797 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC12 GPR132 15527548 1331786 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC12 GPR87 15527548 1331866 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC12 IL1B 10728932 579474 *Effects* of TNF-alpha and on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC12 IL1B 12869928 1112263 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Regulation MUC12 IL1B 14527933 1185867 *Regulation* of MUC5AC [mucin] secretion and airway surface liquid metabolism by in human bronchial epithelia . Regulation MUC12 RARB 10024510 590869 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Regulation MUC12 SPHK1 19835973 2203032 *regulates* [mucin] production via ERK phosphorylation . Regulation MUC12 SPHK1 19835973 2203115 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Regulation MUC12 TNF 10030839 591857 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Regulation MUC12 TNF 10728932 579473 *Effects* of and IL-1 beta on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC12 TNF 11475334 841824 The *effects* of IL-4 , IL-13 , IL-1beta , IL-8 and on 15-LO isoenzyme mRNA and protein expression , total 15-LO enzyme activity and [mucin] secretion were examined in cultures of normal human bronchial epithelial cells . Regulation MUC12 TNF 1748477 172085 The *effects* of on the FC gamma IBS and [mucin] production could not be attributed to a decreased proliferative rate of the cells , as the cells ' incorporation of 5-bromo-2'-deoxyuridine was unaffected . Regulation MUC12 TNF 7842630 286502 *Effect* of interferon-gamma and on MUC1 [mucin] expression in ovarian carcinoma cell lines . Regulation MUC12 TP63 24895124 2951937 Furthermore , inhibition of mucin-type O-linked glycosylation suppressed the *effect* of on increasing [mucin] production and protecting intestinal epithelial cells from TNF induced apoptosis in colon organ culture . Regulation MUC13 EPHB2 16983494 1617470 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Regulation MUC13 EPHB2 17237423 1690046 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Regulation MUC13 GPR115 15527548 1331890 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC13 GPR132 15527548 1331879 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC13 GPR87 15527548 1331959 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC13 IL1B 10728932 579476 *Effects* of TNF-alpha and on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC13 IL1B 12869928 1112264 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Regulation MUC13 IL1B 14527933 1185868 *Regulation* of MUC5AC [mucin] secretion and airway surface liquid metabolism by in human bronchial epithelia . Regulation MUC13 RARB 10024510 590870 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Regulation MUC13 SPHK1 19835973 2203033 *regulates* [mucin] production via ERK phosphorylation . Regulation MUC13 SPHK1 19835973 2203117 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Regulation MUC13 TNF 10030839 591858 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Regulation MUC13 TNF 10728932 579475 *Effects* of and IL-1 beta on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC13 TNF 11475334 841827 The *effects* of IL-4 , IL-13 , IL-1beta , IL-8 and on 15-LO isoenzyme mRNA and protein expression , total 15-LO enzyme activity and [mucin] secretion were examined in cultures of normal human bronchial epithelial cells . Regulation MUC13 TNF 1748477 172086 The *effects* of on the FC gamma IBS and [mucin] production could not be attributed to a decreased proliferative rate of the cells , as the cells ' incorporation of 5-bromo-2'-deoxyuridine was unaffected . Regulation MUC13 TNF 23149663 2768995 Using gastrointestinal tissue from Muc1- or Muc13-deficient mice in ex vivo culture , MUC1 small interfering RNA ( siRNA ) silencing in MKN7 gastric epithelial cells , and MUC13 siRNA silencing in LS513 intestinal epithelial cells , we showed that loss of MUC1 increased chemokine secretion , whereas loss of [MUC13] decreased chemokine secretion in *response* to . Regulation MUC13 TNF 7842630 286504 *Effect* of interferon-gamma and on MUC1 [mucin] expression in ovarian carcinoma cell lines . Regulation MUC13 TP63 24895124 2951938 Furthermore , inhibition of mucin-type O-linked glycosylation suppressed the *effect* of on increasing [mucin] production and protecting intestinal epithelial cells from TNF induced apoptosis in colon organ culture . Regulation MUC15 EPHB2 16983494 1617454 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Regulation MUC15 EPHB2 17237423 1690030 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Regulation MUC15 GPR115 15527548 1331145 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC15 GPR132 15527548 1331134 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC15 GPR87 15527548 1331214 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC15 IL1B 10728932 579456 *Effects* of TNF-alpha and on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC15 IL1B 12869928 1112256 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Regulation MUC15 IL1B 14527933 1185860 *Regulation* of MUC5AC [mucin] secretion and airway surface liquid metabolism by in human bronchial epithelia . Regulation MUC15 RARB 10024510 590862 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Regulation MUC15 SPHK1 19835973 2203025 *regulates* [mucin] production via ERK phosphorylation . Regulation MUC15 SPHK1 19835973 2203101 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Regulation MUC15 TNF 10030839 591850 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Regulation MUC15 TNF 10728932 579455 *Effects* of and IL-1 beta on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC15 TNF 11475334 841803 The *effects* of IL-4 , IL-13 , IL-1beta , IL-8 and on 15-LO isoenzyme mRNA and protein expression , total 15-LO enzyme activity and [mucin] secretion were examined in cultures of normal human bronchial epithelial cells . Regulation MUC15 TNF 1748477 172078 The *effects* of on the FC gamma IBS and [mucin] production could not be attributed to a decreased proliferative rate of the cells , as the cells ' incorporation of 5-bromo-2'-deoxyuridine was unaffected . Regulation MUC15 TNF 7842630 286488 *Effect* of interferon-gamma and on MUC1 [mucin] expression in ovarian carcinoma cell lines . Regulation MUC15 TP63 24895124 2951930 Furthermore , inhibition of mucin-type O-linked glycosylation suppressed the *effect* of on increasing [mucin] production and protecting intestinal epithelial cells from TNF induced apoptosis in colon organ culture . Regulation MUC16 ACACA 17600317 1804635 *Effect* of dexamethasone and on bacteria induced [mucin] expression in human airway mucosa . Regulation MUC16 ACACA 17600317 1804725 In Calu-3 cells alone had no significant *effect* on [mucin] expression ( P > 0.05 ) . Regulation MUC16 ADAM17 12972643 1143546 From these results , we conclude that *plays* a critical role in [mucin] production by airway epithelial cells by means of a TACE ligand-EGFR cascade in response to various stimuli . Regulation MUC16 ADCY1 15985706 1428890 Both inhibitors , moreover , blunted the [mucin] secretory *responses* to beta-adrenergic agonist generated second messenger , cAMP as well as activator , forskolin . Regulation MUC16 ADCY10 15985706 1428889 Both inhibitors , moreover , blunted the [mucin] secretory *responses* to beta-adrenergic agonist generated second messenger , cAMP as well as activator , forskolin . Regulation MUC16 ADCY2 15985706 1428891 Both inhibitors , moreover , blunted the [mucin] secretory *responses* to beta-adrenergic agonist generated second messenger , cAMP as well as activator , forskolin . Regulation MUC16 ADCY3 15985706 1428892 Both inhibitors , moreover , blunted the [mucin] secretory *responses* to beta-adrenergic agonist generated second messenger , cAMP as well as activator , forskolin . Regulation MUC16 ADCY4 15985706 1428893 Both inhibitors , moreover , blunted the [mucin] secretory *responses* to beta-adrenergic agonist generated second messenger , cAMP as well as activator , forskolin . Regulation MUC16 ADCY5 15985706 1428894 Both inhibitors , moreover , blunted the [mucin] secretory *responses* to beta-adrenergic agonist generated second messenger , cAMP as well as activator , forskolin . Regulation MUC16 ADCY6 15985706 1428895 Both inhibitors , moreover , blunted the [mucin] secretory *responses* to beta-adrenergic agonist generated second messenger , cAMP as well as activator , forskolin . Regulation MUC16 ADCY7 15985706 1428896 Both inhibitors , moreover , blunted the [mucin] secretory *responses* to beta-adrenergic agonist generated second messenger , cAMP as well as activator , forskolin . Regulation MUC16 ADCY8 15985706 1428897 Both inhibitors , moreover , blunted the [mucin] secretory *responses* to beta-adrenergic agonist generated second messenger , cAMP as well as activator , forskolin . Regulation MUC16 ADCY9 15985706 1428898 Both inhibitors , moreover , blunted the [mucin] secretory *responses* to beta-adrenergic agonist generated second messenger , cAMP as well as activator , forskolin . Regulation MUC16 AQP5 16500622 1528950 *Regulation* of MUC5AC [mucin] secretion by depletion of in SPC-A1 cells . Regulation MUC16 AQP5 21455588 2417362 Here , our aim was to explore the *effects* of expression on [mucin] production in lung adenocarcinoma . Regulation MUC16 ARSD 22186242 2518491 The aim of this study was to evaluate the *effect* of on the inflammatory process and [mucin] gene expression in nasal epithelial cells . Regulation MUC16 ARSD 22402586 2600472 To investigate the *effect* of on [mucin] production in human respiratory epithelial cells in vitro and in allergic murine nasal epithelial cells . Regulation MUC16 ARSD 22754714 2623119 The purpose of this study was to investigate the *effect* of on inflammation and [mucin] production in the airways of allergic mice . Regulation MUC16 C3 17400733 1748611 To determine if the receptor with its ligand *regulates* airway epithelial [mucin] production . Regulation MUC16 CA2 1340298 209272 PKC inhibitors , H7 and staurosporine inhibited E. histolytica ( 37 and 75 % ) and PMA ( 46 and 100 % ) -induced mucin secretion , whereas in *response* to ionophore [mucin] secretion was augmented ( 56 and 17 % ) . Regulation MUC16 CA2 8178999 256045 Stimulation of [mucin] secretion by forskolin ( 5 x 10 ( -5 ) M ) was not significantly *affected* by the reduction of medium to 47 and 129 nM , equivalent to published values for intracellular Ca2+ concentration ([Ca2+]i) . Regulation MUC16 CALM3 3019145 63057 The *involvement* of in rat submandibular gland [mucin] secretion was investigated in vitro using a dispersed cell preparation . Regulation MUC16 CD8A 16272309 1479319 The immunological switch provided by Th-Th cooperation was sufficient to induce [MUC] .1-specific CD4 and T cell *responses* in MUC .1-transgenic mice , and protect them permanently from tumor growth . Regulation MUC16 CDC73 1316134 185585 The stimulatory *effect* of on both [mucin] secretion and formation of HETEs was inhibited by the PAF receptor antagonists , CV-3988 and Ro 19 3704 , with Ro 19 3704 acting at a concentration 10-fold lower than CV-3988 in inhibiting both effects . Regulation MUC16 CDC73 3653044 78142 The stimulatory *effect* of on [mucin] secretion is blocked by equimolar concentrations of nordihydroguiaretic acid ( NDGA ) a `` mixed '' inhibitor of both cyclo- and lipoxygenase pathways of arachidonic acid metabolism . Regulation MUC16 CDC73 3653044 78217 In addition , the stimulatory *effect* of on [mucin] secretion is not altered by FPL-55712 , a receptor antagonist of LTD4 . Regulation MUC16 CDH1 21512244 2428675 However , the *role* of in modulating [mucin] production is not completely understood . Regulation MUC16 CFTR 10207304 606821 Several additional , initially unexpected *effects* of on cellular functions , such as exocytosis , [mucin] secretion and regulation of the intracellular pH were reported during the past . Regulation MUC16 CFTR 9831904 551559 7. Correction of the defective [mucin] secretion *response* did not correlate with ability to stimulate mucin secretion and did not require potentiation of beta-adrenergic induced increases in cyclic AMP . Regulation MUC16 CISH 2435620 70950 Characterization of newly established human ovarian carcinoma cell line -- special reference of the *effects* of on cellular proliferation and release of [CA125] . Regulation MUC16 CLCA1 17426222 1723935 In this study , we investigated the *role* of the putative calcium activated and its blocker , niflumic acid , in cigarette smoke induced [mucin] synthesis both in vivo and in vitro . Regulation MUC16 CLCA1 17621552 1769981 These data suggest that may *play* a role in LPS induced [mucin] expression in human airway mucosa . Regulation MUC16 CPB1 12165868 973002 In this study , we have investigated the *effect* of on plasma levels of [CA 125] and CEA . Regulation MUC16 CPB2 12165868 973003 In this study , we have investigated the *effect* of on plasma levels of [CA 125] and CEA . Regulation MUC16 CREB1 17646388 1793450 *Regulation* of [mucin] gene expression by via a nonclassical retinoic acid signaling pathway . Regulation MUC16 CREB3 17646388 1793451 *Regulation* of [mucin] gene expression by via a nonclassical retinoic acid signaling pathway . Regulation MUC16 CREB5 17646388 1793449 *Regulation* of [mucin] gene expression by via a nonclassical retinoic acid signaling pathway . Regulation MUC16 CSN2 18558707 1934834 The *effect* of hydrolyzed ( HC ) on the expression of three [mucin] genes ( Muc2 , Muc3 , and Muc4 ) in the rat intestine was investigated using quantitative real-time polymerase chain reaction . Regulation MUC16 CSN3 18558707 1934833 The *effect* of hydrolyzed ( HC ) on the expression of three [mucin] genes ( Muc2 , Muc3 , and Muc4 ) in the rat intestine was investigated using quantitative real-time polymerase chain reaction . Regulation MUC16 CTR9 1316134 185586 The stimulatory *effect* of on both [mucin] secretion and formation of HETEs was inhibited by the PAF receptor antagonists , CV-3988 and Ro 19 3704 , with Ro 19 3704 acting at a concentration 10-fold lower than CV-3988 in inhibiting both effects . Regulation MUC16 CTR9 3653044 78143 The stimulatory *effect* of on [mucin] secretion is blocked by equimolar concentrations of nordihydroguiaretic acid ( NDGA ) a `` mixed '' inhibitor of both cyclo- and lipoxygenase pathways of arachidonic acid metabolism . Regulation MUC16 CTR9 3653044 78218 In addition , the stimulatory *effect* of on [mucin] secretion is not altered by FPL-55712 , a receptor antagonist of LTD4 . Regulation MUC16 DEFA1B 12871849 1185318 Because of the role of cell proliferation in epithelial wound repair , we investigated the *effect* of on airway epithelial wound closure and [mucin] gene expression in vitro . Regulation MUC16 DEFA1B 18931390 2013603 Because human neutrophil peptide-1 (HNP-1) , an antimicrobial peptide in neutrophils , exists in high concentrations in the airway fluid of these patients , we examined the direct *effect* of on MUC5AC [mucin] production using NCI-H292 cells . Regulation MUC16 DUOX1 15640347 1362912 From these results , we conclude that *plays* a critical role in [mucin] expression by airway epithelial cells through PKCdelta/PKC-Duox1-ROS-TACE-pro-ligand-EGF receptor cascade . Regulation MUC16 DUSP1 18782768 1980493 *regulates* the induction of MUC5AC [mucin] by Streptococcus pneumoniae pneumolysin by inhibiting the PAK4-JNK signaling pathway . Regulation MUC16 EDN1 15347558 1333668 ( 1 muM ) did not *affect* [mucin] secretion stimulated by ATP ( 100 muM ) but secretion in response to ATP ( 10 muM ) was inhibited by 63.3 +/- 11.8 % . Regulation MUC16 EEF1A2 11249777 764211 In murine and human studies , the vaccine has been shown to stimulate antibodies and [mucin-specific] T-cell *responses* . Regulation MUC16 EGF 11133506 769246 Activation of receptors is *responsible* for [mucin] synthesis induced by cigarette smoke . Regulation MUC16 EGF 11133506 769261 Here we show that activation of is *responsible* for [mucin] production after inhalation of cigarette smoke in airways in vitro and in vivo . Regulation MUC16 EGF 11769575 890435 The production of [mucin] was *regulated* by in vitro . Regulation MUC16 EGF 16009452 1453032 In addition , *regulates* [mucin] secretion in normal airway goblet cells . Regulation MUC16 EGF 9419754 291234 We investigated quantitatively and immunohistochemically stimulated CA125 release from WISH cells and the *effect* of EGF on [CA125] phosphorylation . Regulation MUC16 EGFR 11133503 769231 These findings indicate that signaling is *involved* in IL-13 induced [mucin] production . Regulation MUC16 EGFR 11686870 875901 *Role* of activation in regulating [mucin] synthesis . Regulation MUC16 EGFR 15516478 1328586 *Roles* of activation in epithelial cell repair and [mucin] production in airway epithelium . Regulation MUC16 EGFR 15621865 1184777 Since this pattern of labelling must be related to the internalisation process of the ligand-GFR complex , our results support the hypothesis that activation takes place in mucous cells and *affects* [mucin] production in human salivary glands . Regulation MUC16 EGFR 20724237 2317940 It is known that activation of and its downstream signaling cascade are *involved* in [mucin] production . Regulation MUC16 EGFR 21036164 2365480 Matrix metalloproteinases ( MMPs ) , especially MMP-9 , have been found to increase the expression of , a possible *regulator* of acrolein induced [mucin] expression in the airway epithelium . Regulation MUC16 EGFR 21868713 2546722 This study assessed the *role* of signaling in mediating the effects of exposure to vesicants on the secretion of cytokines and production of [mucin] in human airway epithelial cells . Regulation MUC16 ELANE 10763814 580043 The *effects* of secretagogues such as , 8-bromocyclic AMP , ionomycin , phorbol-12-myristate-13-acetate and on [mucin] secretion were also investigated . Regulation MUC16 EPHB2 16983494 1617456 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Regulation MUC16 EPHB2 17237423 1690032 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Regulation MUC16 ERN1 23168839 2769064 *dependent* [mucin] production is mediated , at least in part , by activation of the transcription factor X-box binding protein-1 (XBP-1) and the resulting XBP-1 dependent transcription of anterior gradient homolog 2 , a gene implicated in airway and intestinal epithelial mucin production . Regulation MUC16 F2RL1 18028876 1835966 The aim of this study was to examine the *effect* of activation on [mucin] secretion in the human colonic goblet cell line HT29-Cl.16E and the intracellular pathways involved . Regulation MUC16 FOXG1 23200466 2730636 *Effect* of Bifidobacterium bifidum on gastric protection and [mucin] production in an acute gastric injury rat model . Regulation MUC16 GAB2 22859374 2692219 Docking protein *regulates* [mucin] expression and goblet cell hyperplasia through TYK2/STAT6 pathway . Regulation MUC16 GATA5 14986113 1295061 The aim of the current study is to elucidate whether or not expression of [mucin] genes is *regulated* by . Regulation MUC16 GATA5 14986113 1295076 Reporter gene assays were employed to analyze the *effect* of on the promoter activity of [mucin] genes . Regulation MUC16 GATA5 14986113 1295091 These findings indicate that may *play* important roles in the regulation of [mucin] expression and gastrointestinal epithelial cell differentiation . Regulation MUC16 GNAS 23403822 2748675 Mutant might *play* a direct role in the prominent [mucin] production that is a hallmark of LAMN . Regulation MUC16 GPR1 15527548 1331268 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR101 15527548 1331224 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR107 15527548 1331229 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR108 15527548 1331228 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR110 15527548 1331234 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR111 15527548 1331235 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR112 15527548 1331236 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR113 15527548 1331233 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR114 15527548 1331237 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR115 15527548 1331238 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR116 15527548 1331239 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR119 15527548 1331240 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR12 15527548 1331269 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR123 15527548 1331221 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR124 15527548 1331230 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR125 15527548 1331222 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR126 15527548 1331223 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR128 15527548 1331241 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR132 15527548 1331227 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR133 15527548 1331242 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR135 15527548 1331243 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR137 15527548 1331261 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR139 15527548 1331244 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR141 15527548 1331245 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR142 15527548 1331246 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR143 15527548 1331247 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR144 15527548 1331232 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR146 15527548 1331249 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR148 15527548 1331253 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR149 15527548 1331255 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR15 15527548 1331270 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR150 15527548 1331256 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR151 15527548 1331254 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR152 15527548 1331252 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR153 15527548 1331251 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR155 15527548 1331250 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR156 15527548 1331248 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR157 15527548 1331257 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR158 15527548 1331258 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR160 15527548 1331259 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR161 15527548 1331260 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR162 15527548 1331225 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR17 15527548 1331271 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR171 15527548 1331263 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR173 15527548 1331231 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR174 15527548 1331264 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR176 15527548 1331267 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR179 15527548 1331266 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR18 15527548 1331272 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR180 15527548 1331262 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR182 15527548 1331219 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR183 15527548 1331265 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR19 15527548 1331273 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR20 15527548 1331274 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR21 15527548 1331275 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR22 15527548 1331276 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR25 15527548 1331277 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR26 15527548 1331278 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR27 15527548 1331279 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR3 15527548 1331280 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR31 15527548 1331281 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR32 15527548 1331282 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR33 15527548 1331283 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR34 15527548 1331284 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR35 15527548 1331285 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR36 15527548 1331286 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR37 15527548 1331287 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR39 15527548 1331288 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR4 15527548 1331289 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR42 15527548 1331290 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR45 15527548 1331291 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR50 15527548 1331292 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR52 15527548 1331293 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR55 15527548 1331294 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR56 15527548 1331295 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR6 15527548 1331296 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR61 15527548 1331216 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR62 15527548 1331217 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR63 15527548 1331218 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR64 15527548 1331297 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR65 15527548 1331298 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR68 15527548 1331299 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR75 15527548 1331301 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR78 15527548 1331302 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR79 15527548 1331303 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR82 15527548 1331304 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR83 15527548 1331300 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR84 15527548 1331305 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR85 15527548 1331306 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR87 15527548 1331307 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR88 15527548 1331308 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR97 15527548 1331220 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 GPR98 15527548 1331226 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC16 HCL1 2887352 75959 Intestinal release of [mucin] in *response* to and taurocholate : effect of indomethacin . Regulation MUC16 HCL2 2887352 75960 Intestinal release of [mucin] in *response* to and taurocholate : effect of indomethacin . Regulation MUC16 HCL3 2887352 75961 Intestinal release of [mucin] in *response* to and taurocholate : effect of indomethacin . Regulation MUC16 HMGB1 22521432 2595698 In this study , we investigated the *effect* of on the expression of [mucin (MUC)] genes in human airway epithelial cells . Regulation MUC16 HMGB1 22521432 2595728 We showed that markedly increased MUC8 expression , and that the expression of other [MUC] genes was also *regulated* by HMGB1 . Regulation MUC16 HPR 17035399 1630966 There was no *effect* of <4-HPR> on changes in serum [CA125] , Ki67 expression , which were assessed in 75 % of subjects , and cytomorphometric variables , which were assessed in 80 % of subjects . Regulation MUC16 HSPG2 17616647 1786937 Hence , signaling may *play* a key role in regulated [mucin] secretion , whether the event is initiated by mediators interacting with GPCRs or RYKs . Regulation MUC16 IFNG 17194718 1732417 Furthermore , air-liquid interface cultures of mouse primary tracheal epithelial cells were performed to examine the *effects* of on [mucin] expression . Regulation MUC16 IFNG 19737027 2264250 We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and [MUC] expression is *regulated* by , interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen . Regulation MUC16 IFNG 7515824 257268 The aim of the present study was ( 1 ) to investigate the regulatory *effects* of on baseline and stimulated [mucin] secretion elicited by an increase in intracellular cAMP , either a short-term increase ( induced by vasoactive intestinal peptide or by forskolin ) or a long-term increase ( cholera toxin induced ) , and ( 2 ) to attempt to delineate the site of action of interferon-gamma . Regulation MUC16 IFNG 7842630 286491 *Effect* of and TNF-alpha on MUC1 [mucin] expression in ovarian carcinoma cell lines . Regulation MUC16 IKBKB 17237423 1690033 A novel *role* for IkappaB kinase (IKK) alpha and in ERK dependent up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Regulation MUC16 IL13 11475334 841807 The *effects* of IL-4 , , IL-1beta , IL-8 and TNFalpha on 15-LO isoenzyme mRNA and protein expression , total 15-LO enzyme activity and [mucin] secretion were examined in cultures of normal human bronchial epithelial cells . Regulation MUC16 IL13 12403127 1009571 This study aimed to investigate the direct *effect* of on [mucin] gene expression and mucin secretion in cultured normal human nasal epithelial cells . Regulation MUC16 IL13 23449738 2803769 In the ovalbumin induced lung inflammation model , the bifunctional IL-4/IL-13 antagonist reduced the IL-4 dependent rise in serum IgE titers , and reduced *dependent* airway hyperresponsiveness , lung inflammation , [mucin] gene expression , and serum chitinase responses . Regulation MUC16 IL17A 16859642 1592412 The *effects* of on [mucin] production and growth of airway epithelial cells were examined . Regulation MUC16 IL1B 10728932 579458 *Effects* of TNF-alpha and on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC16 IL1B 12869928 1112257 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Regulation MUC16 IL1B 14527933 1185861 *Regulation* of MUC5AC [mucin] secretion and airway surface liquid metabolism by in human bronchial epithelia . Regulation MUC16 IL31 23392388 2781000 To investigate the *effects* of on [mucin] gene expression ( MUC5AC ) in patients with allergic rhinitis and in human airway epithelial cells . Regulation MUC16 IL4 12125997 965872 Among inflammatory mediators , is *responsible* for the decrease in MUC5AC mRNA and MUC5AC [mucin] secretion . Regulation MUC16 IL4 19737027 2264251 We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and [MUC] expression is *regulated* by interferon (IFN)-gamma , , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen . Regulation MUC16 IL4 9115759 423532 Thus , transgenic mice that overexpress murine IL-4 selectively within the lung were used to study the *effect* of on mucus glycoprotein gene expression and [mucin] release . Regulation MUC16 IL6 15016409 1220871 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Regulation MUC16 IL6 19201396 2044129 Little is known regarding the *effects* of released by tumor infiltrating macrophages on the [mucin] expression of colon cancer cells . Regulation MUC16 IL8 11475334 841808 The *effects* of IL-4 , IL-13 , IL-1beta , and TNFalpha on 15-LO isoenzyme mRNA and protein expression , total 15-LO enzyme activity and [mucin] secretion were examined in cultures of normal human bronchial epithelial cells . Regulation MUC16 IL8 19596978 2112025 *regulates* [mucin] gene expression at the posttranscriptional level in lung epithelial cells . Regulation MUC16 IL8 19596978 2112040 In this study , the *effects* of on expression of two major airway [mucin] genes , MUC5AC and MUC5B , were evaluated . Regulation MUC16 IL9 10837360 699360 In vitro , our studies showed that IL-9 also induces expression of MUC2 and MUC5AC in human primary lung cultures and in the human muccoepidermoid NCI-H292 cell line , indicating a direct *effect* of on inducing [mucin] expression in these cells . Regulation MUC16 JUN 19956440 2172617 Ras-Raf1-ERK1/2 dependent activation positively *regulates* MUC5AC [mucin] induction by S. pneumoniae , whereas MEKK3-JNK1/2 dependent AP-1 activation negatively regulates it . Regulation MUC16 LEO1 1316134 185589 The stimulatory *effect* of on both [mucin] secretion and formation of HETEs was inhibited by the PAF receptor antagonists , CV-3988 and Ro 19 3704 , with Ro 19 3704 acting at a concentration 10-fold lower than CV-3988 in inhibiting both effects . Regulation MUC16 LEO1 3653044 78146 The stimulatory *effect* of on [mucin] secretion is blocked by equimolar concentrations of nordihydroguiaretic acid ( NDGA ) a `` mixed '' inhibitor of both cyclo- and lipoxygenase pathways of arachidonic acid metabolism . Regulation MUC16 LEO1 3653044 78221 In addition , the stimulatory *effect* of on [mucin] secretion is not altered by FPL-55712 , a receptor antagonist of LTD4 . Regulation MUC16 LEP 16455789 1534329 Here , we studied the *effects* of on colonic mucus secretion and rat [mucin] 2 ( rMuc2 ) expression . Regulation MUC16 LEP 16455789 1534344 The *effects* of alone or in association with protein kinase C ( PKC ) and phosphatidylinositol 3-kinase (PI3K) inhibitors on [mucin] secreted by human mucus secreting HT29-MTX cells were determined . Regulation MUC16 LEP 17093905 1660996 Moreover , amplification in the *effect* of on the LPS induced decrease in [mucin] synthesis was attained with cPLA2 inhibitor , MAFP as well as PAF receptor antagonist , BN52020 , while the reversal of the leptin effect occurred in the presence of exogenous PAF . Regulation MUC16 LEP 17440231 1729587 Moreover , potentiation in the *effect* of on the LPS induced decrease in [mucin] synthesis was attained with cPLA(2) inhibitor , MAFP as well as PAF receptor antagonist , BN52020 . Regulation MUC16 LEP 20422702 2247071 We aimed to demonstrate the differential expression of leptin receptors in normal human nasal mucosa and nasal polyps , and to elucidate the *effects* of on [mucin] gene expression in human nasal polyp epithelial cells . Regulation MUC16 LEP 20497020 2263653 We investigated the *effects* of on [mucin] expression in human airway epithelial cells and the signaling pathways . Regulation MUC16 LGALS3 12198708 982221 The *effect* of on MUC2 [mucin] production was assessed by stable transfection of sense and antisense galectin-3 expression constructs under the control of constitutive or tetracycline-inducible promoters into human colon cancer cells . Regulation MUC16 MAPK1 15033700 1183888 The *effect* of p38 on [mucin] gene expression and apoptosis in Helicobacter pylori infected gastric epithelial cells . Regulation MUC16 MAPK1 19542310 2116426 Msb2 signaling [mucin] *controls* activation of Cek1 in Candida albicans . Regulation MUC16 MAPK10 15033700 1183889 The *effect* of p38 on [mucin] gene expression and apoptosis in Helicobacter pylori infected gastric epithelial cells . Regulation MUC16 MAPK10 19542310 2116427 Msb2 signaling [mucin] *controls* activation of Cek1 in Candida albicans . Regulation MUC16 MAPK11 15033700 1183890 The *effect* of p38 on [mucin] gene expression and apoptosis in Helicobacter pylori infected gastric epithelial cells . Regulation MUC16 MAPK11 19542310 2116428 Msb2 signaling [mucin] *controls* activation of Cek1 in Candida albicans . Regulation MUC16 MAPK12 15033700 1183891 The *effect* of p38 on [mucin] gene expression and apoptosis in Helicobacter pylori infected gastric epithelial cells . Regulation MUC16 MAPK12 19542310 2116429 Msb2 signaling [mucin] *controls* activation of Cek1 in Candida albicans . Regulation MUC16 MAPK13 15033700 1183892 The *effect* of p38 on [mucin] gene expression and apoptosis in Helicobacter pylori infected gastric epithelial cells . Regulation MUC16 MAPK13 19542310 2116430 Msb2 signaling [mucin] *controls* activation of Cek1 in Candida albicans . Regulation MUC16 MAPK14 15033700 1183893 The *effect* of p38 on [mucin] gene expression and apoptosis in Helicobacter pylori infected gastric epithelial cells . Regulation MUC16 MAPK14 19542310 2116431 Msb2 signaling [mucin] *controls* activation of Cek1 in Candida albicans . Regulation MUC16 MAPK15 15033700 1183887 The *effect* of p38 on [mucin] gene expression and apoptosis in Helicobacter pylori infected gastric epithelial cells . Regulation MUC16 MAPK15 19542310 2116425 Msb2 signaling [mucin] *controls* activation of Cek1 in Candida albicans . Regulation MUC16 MAPK3 15033700 1183894 The *effect* of p38 on [mucin] gene expression and apoptosis in Helicobacter pylori infected gastric epithelial cells . Regulation MUC16 MAPK3 19542310 2116432 Msb2 signaling [mucin] *controls* activation of Cek1 in Candida albicans . Regulation MUC16 MAPK3 19956440 2172514 In the present study , we showed that positive *regulation* of MUC5AC [mucin] expression by is dependent on Ras-Raf-1 signaling pathway , whereas the negative regulation of MUC5AC expression by JNK1/2 is dependent on MEKK3 . Regulation MUC16 MAPK3 19956440 2172618 dependent AP-1 activation positively *regulates* MUC5AC [mucin] induction by S. pneumoniae , whereas MEKK3-JNK1/2 dependent AP-1 activation negatively regulates it . Regulation MUC16 MAPK4 15033700 1183895 The *effect* of p38 on [mucin] gene expression and apoptosis in Helicobacter pylori infected gastric epithelial cells . Regulation MUC16 MAPK4 19542310 2116433 Msb2 signaling [mucin] *controls* activation of Cek1 in Candida albicans . Regulation MUC16 MAPK6 15033700 1183896 The *effect* of p38 on [mucin] gene expression and apoptosis in Helicobacter pylori infected gastric epithelial cells . Regulation MUC16 MAPK6 19542310 2116434 Msb2 signaling [mucin] *controls* activation of Cek1 in Candida albicans . Regulation MUC16 MAPK7 15033700 1183897 The *effect* of p38 on [mucin] gene expression and apoptosis in Helicobacter pylori infected gastric epithelial cells . Regulation MUC16 MAPK7 19542310 2116435 Msb2 signaling [mucin] *controls* activation of Cek1 in Candida albicans . Regulation MUC16 MAPK8 15033700 1183898 The *effect* of p38 on [mucin] gene expression and apoptosis in Helicobacter pylori infected gastric epithelial cells . Regulation MUC16 MAPK8 19542310 2116436 Msb2 signaling [mucin] *controls* activation of Cek1 in Candida albicans . Regulation MUC16 MAPK9 15033700 1183899 The *effect* of p38 on [mucin] gene expression and apoptosis in Helicobacter pylori infected gastric epithelial cells . Regulation MUC16 MAPK9 19542310 2116437 Msb2 signaling [mucin] *controls* activation of Cek1 in Candida albicans . Regulation MUC16 MARCKS 18314541 1919456 *regulation* of [mucin] secretion by airway epithelium in vitro : interaction with chaperones . Regulation MUC16 MARCKS 18314541 1919487 The results provide the first evidence that CSP and HSP70 , and their interactions with , are *involved* in [mucin] secretion . Regulation MUC16 MARCKS 21281703 2493964 In this review , properties of and how the protein may *regulate* [mucin] secretion at a cellular level will be discussed . Regulation MUC16 MARCKS 22710197 2700970 Calpain and protein *regulation* of airway [mucin] secretion . Regulation MUC16 MMP9 19389382 2089313 *Role* of in lipopolysaccharide induced [mucin] production in human airway epithelial cells . Regulation MUC16 MSI1 17621552 1769952 We also investigated the *effect* of NFA and on LPS induced [mucin] up-regulation . Regulation MUC16 MSI2 17621552 1769951 We also investigated the *effect* of NFA and on LPS induced [mucin] up-regulation . Regulation MUC16 MUC4 11751498 889930 [Mucin (MUC)] gene expression in human pancreatic adenocarcinoma and chronic pancreatitis : a potential *role* of as a tumor marker of diagnostic significance . Regulation MUC16 MUC5AC 16773182 1572860 [mucin] gene *regulation* in pancreatic cancer cells . Regulation MUC16 MUC5AC 22659655 2610835 The levels of intracellular and secreted MUC5AC of cold treated group were significantly higher than those of control group ( P < 0.05 ) . BCTC attenuated the cold induced synthesis and secretion of MUC5AC when compared with cold treated group ( P < 0.05 ) . Transfection of 16HBE cells with the MARCKS-PSD mutant cDNA resulted in significant inhibition of [mucin] secretion in *response* to cold , and significantly higher level of intracellular than that of control group ( P < 0.01 ) , whereas transfection with the vector DNA or the wild-type MARCKS cDNA had no effect on the mucin synthesis and secretion in response to cold ( P > 0.05 ) . Regulation MUC16 MUC5B 12076334 956892 In addition , the and MUC8 gene may *play* an important role in [mucin] secretion in fully differentiated human nasal epithelial cells . Regulation MUC16 MYD88 18978302 2053288 TLR3 mediated [mucin] induction was negatively *regulated* by , and only partially dependent on TRIF , which suggests a departure from well documented TLR3 signaling paradigm that mediates inflammatory and other innate defense gene inductions . Regulation MUC16 NGF 18201532 1839002 [ The *effect* of on proliferation and expression of [mucin] gene in human conjunctival goblet cells ] . Regulation MUC16 NGF 19407015 2135697 In vitro evidence of *effects* on human conjunctival epithelial cell differentiation and [mucin] gene expression . Regulation MUC16 NKX2-1 21126317 2372496 The mouse Muc5b [mucin] gene is transcriptionally *regulated* by ( TTF-1 ) and GATA-6 transcription factors . Regulation MUC16 P2RY2 15218074 1289238 SPOC1 airway goblet cells secrete [mucin] in *response* to receptor agonists and to secretagogues , phorbol 12-myristate 13-acetate ( PMA ) and ionomycin , which mobilize elements of the phospholipase C pathway , PKC and Ca2+ , respectively . Regulation MUC16 P2RY2 9778415 540390 *Regulation* of ocular [mucin] secretion by nucleotide receptors in rabbit and human conjunctiva . Regulation MUC16 P2RY4 18604596 1941682 Luminal A ( 2b ) , P2Y(2) , , and P2Y(6) receptors are *involved* in fluid and Cl ( - ) , HCO ( 3 ) ( - ) , K ( + ) , or [mucin] secretion . Regulation MUC16 P2RY6 18604596 1941683 Luminal A ( 2b ) , P2Y(2) , P2Y(4) , and receptors are *involved* in fluid and Cl ( - ) , HCO ( 3 ) ( - ) , K ( + ) , or [mucin] secretion . Regulation MUC16 PAF1 1316134 185587 The stimulatory *effect* of on both [mucin] secretion and formation of HETEs was inhibited by the PAF receptor antagonists , CV-3988 and Ro 19 3704 , with Ro 19 3704 acting at a concentration 10-fold lower than CV-3988 in inhibiting both effects . Regulation MUC16 PAF1 3653044 78144 The stimulatory *effect* of on [mucin] secretion is blocked by equimolar concentrations of nordihydroguiaretic acid ( NDGA ) a `` mixed '' inhibitor of both cyclo- and lipoxygenase pathways of arachidonic acid metabolism . Regulation MUC16 PAF1 3653044 78219 In addition , the stimulatory *effect* of on [mucin] secretion is not altered by FPL-55712 , a receptor antagonist of LTD4 . Regulation MUC16 PAK2 17555715 1753067 Opposing *roles* of and PAK4 in synergistic induction of MUC5AC [mucin] by bacterium NTHi and EGF . Regulation MUC16 PAK4 17555715 1753066 Opposing *roles* of PAK2 and in synergistic induction of MUC5AC [mucin] by bacterium NTHi and EGF . Regulation MUC16 PIK3CA 12482999 1024653 These results suggest that the IL-1beta mediated MUC2 gene expression and [mucin] secretion in NCI-H292 cells are regulated through activation of the PKC-MEK/ERK pathway , and that is also *involved* in the IL-1beta mediated MUC2 gene expression and mucin secretion . Regulation MUC16 PIK3R1 12482999 1024654 These results suggest that the IL-1beta mediated MUC2 gene expression and [mucin] secretion in NCI-H292 cells are regulated through activation of the PKC-MEK/ERK pathway , and that is also *involved* in the IL-1beta mediated MUC2 gene expression and mucin secretion . Regulation MUC16 PLA2G1B 11484413 844666 ATP induced [mucin] release from cultured airway goblet cell *involves* , in part , activation of . Regulation MUC16 PLA2G1B 11484413 844696 These results suggest that is *involved* in ATP induced [mucin] release and its activation is sequential to the PLC-PKC pathway . Regulation MUC16 PLA2G4A 16983494 1617457 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* ERK dependent activation that leads to up-regulation in PAF production and ET-1 generation . Regulation MUC16 PPARG 16443643 1567270 However , no data are available on the *role* of in smoke induced [mucin] production . Regulation MUC16 PTPN6 20117097 2213212 In this study , we investigated the *role* of in [mucin] secretion triggered by oxidative stress . Regulation MUC16 PTPN6 20117097 2213227 Our results clearly indicate that *plays* an important role in airway [mucin] production through regulating oxidative stress . Regulation MUC16 RABEPK 24895124 2951900 Because activation of EGFR has been shown to up-regulate mucin production in goblet cells , the purpose of this study was to investigate the effects and mechanisms of *regulation* of [mucin] production . Regulation MUC16 RAF1 19956440 2172619 dependent AP-1 activation positively *regulates* MUC5AC [mucin] induction by S. pneumoniae , whereas MEKK3-JNK1/2 dependent AP-1 activation negatively regulates it . Regulation MUC16 RARB 10024510 590863 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Regulation MUC16 RETNLB 18300276 1919321 We examined the *effect* of recombinant on [mucin] secretion by human mucus secreting HT29-Cl.16E cells in culture and by mouse colonic goblet cells in vivo . Regulation MUC16 SELP 11854515 914008 Synergistic *effects* of L- and in facilitating tumor metastasis can involve [non-mucin] ligands and implicate leukocytes as enhancers of metastasis . Regulation MUC16 SETD2 21544845 2554299 These effects are prevented by small interfering RNA ( siRNA ) for HIF-1a , indicating that cigarette smoke induced [mucin] production is *dependent* . Regulation MUC16 SPHK1 19835973 2203026 *regulates* [mucin] production via ERK phosphorylation . Regulation MUC16 SPHK1 19835973 2203103 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Regulation MUC16 SPHK2 19835973 2203104 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Regulation MUC16 TCF12 15541382 1337120 The murine Muc2 [mucin] gene is transcriptionally *regulated* by the zinc-finger GATA-4 in intestinal cells . Regulation MUC16 TCF15 15541382 1337121 The murine Muc2 [mucin] gene is transcriptionally *regulated* by the zinc-finger GATA-4 in intestinal cells . Regulation MUC16 TCF19 15541382 1337122 The murine Muc2 [mucin] gene is transcriptionally *regulated* by the zinc-finger GATA-4 in intestinal cells . Regulation MUC16 TCF20 15541382 1337123 The murine Muc2 [mucin] gene is transcriptionally *regulated* by the zinc-finger GATA-4 in intestinal cells . Regulation MUC16 TCF21 15541382 1337124 The murine Muc2 [mucin] gene is transcriptionally *regulated* by the zinc-finger GATA-4 in intestinal cells . Regulation MUC16 TCF23 15541382 1337128 The murine Muc2 [mucin] gene is transcriptionally *regulated* by the zinc-finger GATA-4 in intestinal cells . Regulation MUC16 TCF24 15541382 1337130 The murine Muc2 [mucin] gene is transcriptionally *regulated* by the zinc-finger GATA-4 in intestinal cells . Regulation MUC16 TCF25 15541382 1337129 The murine Muc2 [mucin] gene is transcriptionally *regulated* by the zinc-finger GATA-4 in intestinal cells . Regulation MUC16 TCF3 15541382 1337125 The murine Muc2 [mucin] gene is transcriptionally *regulated* by the zinc-finger GATA-4 in intestinal cells . Regulation MUC16 TCF4 15541382 1337126 The murine Muc2 [mucin] gene is transcriptionally *regulated* by the zinc-finger GATA-4 in intestinal cells . Regulation MUC16 TCF7 15541382 1337127 The murine Muc2 [mucin] gene is transcriptionally *regulated* by the zinc-finger GATA-4 in intestinal cells . Regulation MUC16 TGFB1 15466377 1305577 We evaluated bronchial epithelial TGF-beta1 and TGF-beta2 expression and their *effects* on [mucin] expression , and the role of or TGF-beta2 in interleukin (IL)-13 induced mucin expression . Regulation MUC16 TGFB2 15466377 1305578 We evaluated bronchial epithelial TGF-beta1 and expression and their *effects* on [mucin] expression , and the role of TGF-beta1 or TGF-beta2 in interleukin (IL)-13 induced mucin expression . Regulation MUC16 TNF 10030839 591851 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Regulation MUC16 TNF 10728932 579457 *Effects* of and IL-1 beta on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC16 TNF 11475334 841806 The *effects* of IL-4 , IL-13 , IL-1beta , IL-8 and on 15-LO isoenzyme mRNA and protein expression , total 15-LO enzyme activity and [mucin] secretion were examined in cultures of normal human bronchial epithelial cells . Regulation MUC16 TNF 1748477 172079 The *effects* of on the FC gamma IBS and [mucin] production could not be attributed to a decreased proliferative rate of the cells , as the cells ' incorporation of 5-bromo-2'-deoxyuridine was unaffected . Regulation MUC16 TNF 7842630 286490 *Effect* of interferon-gamma and on MUC1 [mucin] expression in ovarian carcinoma cell lines . Regulation MUC16 TP63 24895124 2951931 Furthermore , inhibition of mucin-type O-linked glycosylation suppressed the *effect* of on increasing [mucin] production and protecting intestinal epithelial cells from TNF induced apoptosis in colon organ culture . Regulation MUC16 UGCG 22092504 2509166 The *effect* of on IL-13 induced [mucin] production is not well characterized . Regulation MUC16 UTP15 11694445 876791 The stimulatory *effect* of or ATP on [mucin] secretion was inhibited by pertussis toxin , U73122 , and Calphostin C , but not by PD98059 , suggesting a G-protein/ phospholipase ( PL ) C/protein kinase ( PK ) C-dependent and mitogen activated protein kinase (MAPK) independent signaling pathway . Regulation MUC16 UTP15 11694445 876881 However , the stimulatory *effect* of on [mucin] gene expression was sensitive to pertussis toxin and PD98059 , but not to Calphostin C and U73122 , suggesting a G-protein/MAPK dependent and PLC/PKC independent signaling pathway . Regulation MUC16 UTP15 12737291 1087700 Extracellular *regulates* a variety of biological functions in the airway epithelium , including chloride and fluid transport , mucociliary clearance and [mucin] secretion via the P2Y purinergic receptors . Regulation MUC16 UTP15 14710912 1181403 We also examined the *effect* of ( an agonist for P2Y2 ) and ATPgammaS ( an agonist for P2Y11 ) on mucin secretion and [mucin] gene expression . Regulation MUC16 UTP18 11694445 876789 The stimulatory *effect* of or ATP on [mucin] secretion was inhibited by pertussis toxin , U73122 , and Calphostin C , but not by PD98059 , suggesting a G-protein/ phospholipase ( PL ) C/protein kinase ( PK ) C-dependent and mitogen activated protein kinase (MAPK) independent signaling pathway . Regulation MUC16 UTP18 11694445 876879 However , the stimulatory *effect* of on [mucin] gene expression was sensitive to pertussis toxin and PD98059 , but not to Calphostin C and U73122 , suggesting a G-protein/MAPK dependent and PLC/PKC independent signaling pathway . Regulation MUC16 UTP18 12737291 1087698 Extracellular *regulates* a variety of biological functions in the airway epithelium , including chloride and fluid transport , mucociliary clearance and [mucin] secretion via the P2Y purinergic receptors . Regulation MUC16 UTP18 14710912 1181401 We also examined the *effect* of ( an agonist for P2Y2 ) and ATPgammaS ( an agonist for P2Y11 ) on mucin secretion and [mucin] gene expression . Regulation MUC16 UTP20 11694445 876787 The stimulatory *effect* of or ATP on [mucin] secretion was inhibited by pertussis toxin , U73122 , and Calphostin C , but not by PD98059 , suggesting a G-protein/ phospholipase ( PL ) C/protein kinase ( PK ) C-dependent and mitogen activated protein kinase (MAPK) independent signaling pathway . Regulation MUC16 UTP20 11694445 876877 However , the stimulatory *effect* of on [mucin] gene expression was sensitive to pertussis toxin and PD98059 , but not to Calphostin C and U73122 , suggesting a G-protein/MAPK dependent and PLC/PKC independent signaling pathway . Regulation MUC16 UTP20 12737291 1087696 Extracellular *regulates* a variety of biological functions in the airway epithelium , including chloride and fluid transport , mucociliary clearance and [mucin] secretion via the P2Y purinergic receptors . Regulation MUC16 UTP20 14710912 1181399 We also examined the *effect* of ( an agonist for P2Y2 ) and ATPgammaS ( an agonist for P2Y11 ) on mucin secretion and [mucin] gene expression . Regulation MUC16 UTP23 11694445 876792 The stimulatory *effect* of or ATP on [mucin] secretion was inhibited by pertussis toxin , U73122 , and Calphostin C , but not by PD98059 , suggesting a G-protein/ phospholipase ( PL ) C/protein kinase ( PK ) C-dependent and mitogen activated protein kinase (MAPK) independent signaling pathway . Regulation MUC16 UTP23 11694445 876882 However , the stimulatory *effect* of on [mucin] gene expression was sensitive to pertussis toxin and PD98059 , but not to Calphostin C and U73122 , suggesting a G-protein/MAPK dependent and PLC/PKC independent signaling pathway . Regulation MUC16 UTP23 12737291 1087701 Extracellular *regulates* a variety of biological functions in the airway epithelium , including chloride and fluid transport , mucociliary clearance and [mucin] secretion via the P2Y purinergic receptors . Regulation MUC16 UTP23 14710912 1181404 We also examined the *effect* of ( an agonist for P2Y2 ) and ATPgammaS ( an agonist for P2Y11 ) on mucin secretion and [mucin] gene expression . Regulation MUC16 UTP3 11694445 876790 The stimulatory *effect* of or ATP on [mucin] secretion was inhibited by pertussis toxin , U73122 , and Calphostin C , but not by PD98059 , suggesting a G-protein/ phospholipase ( PL ) C/protein kinase ( PK ) C-dependent and mitogen activated protein kinase (MAPK) independent signaling pathway . Regulation MUC16 UTP3 11694445 876880 However , the stimulatory *effect* of on [mucin] gene expression was sensitive to pertussis toxin and PD98059 , but not to Calphostin C and U73122 , suggesting a G-protein/MAPK dependent and PLC/PKC independent signaling pathway . Regulation MUC16 UTP3 12737291 1087699 Extracellular *regulates* a variety of biological functions in the airway epithelium , including chloride and fluid transport , mucociliary clearance and [mucin] secretion via the P2Y purinergic receptors . Regulation MUC16 UTP3 14710912 1181402 We also examined the *effect* of ( an agonist for P2Y2 ) and ATPgammaS ( an agonist for P2Y11 ) on mucin secretion and [mucin] gene expression . Regulation MUC16 UTP6 11694445 876788 The stimulatory *effect* of or ATP on [mucin] secretion was inhibited by pertussis toxin , U73122 , and Calphostin C , but not by PD98059 , suggesting a G-protein/ phospholipase ( PL ) C/protein kinase ( PK ) C-dependent and mitogen activated protein kinase (MAPK) independent signaling pathway . Regulation MUC16 UTP6 11694445 876878 However , the stimulatory *effect* of on [mucin] gene expression was sensitive to pertussis toxin and PD98059 , but not to Calphostin C and U73122 , suggesting a G-protein/MAPK dependent and PLC/PKC independent signaling pathway . Regulation MUC16 UTP6 12737291 1087697 Extracellular *regulates* a variety of biological functions in the airway epithelium , including chloride and fluid transport , mucociliary clearance and [mucin] secretion via the P2Y purinergic receptors . Regulation MUC16 UTP6 14710912 1181400 We also examined the *effect* of ( an agonist for P2Y2 ) and ATPgammaS ( an agonist for P2Y11 ) on mucin secretion and [mucin] gene expression . Regulation MUC16 VIP 12056823 951953 Secretion of MUC5AC [mucin] from pancreatic cancer cells in *response* to forskolin and . Regulation MUC16 VIP 1671333 152495 To test whether simultaneous activation of the and muscarinic receptors or of beta-adrenoreceptors and muscarinic receptors *affect* [mucin] secretion in a reciprocal manner , we studied some characteristics of the resultant physiologic response in human epithelial cells secreting radiolabeled mucin-like glycoprotein (MLGP) . Regulation MUC16 VIP 20029687 2176815 However , the *effect* of on bronchial [mucin] secretion remains unclear . Regulation MUC16 WDR61 1316134 185588 The stimulatory *effect* of on both [mucin] secretion and formation of HETEs was inhibited by the PAF receptor antagonists , CV-3988 and Ro 19 3704 , with Ro 19 3704 acting at a concentration 10-fold lower than CV-3988 in inhibiting both effects . Regulation MUC16 WDR61 3653044 78145 The stimulatory *effect* of on [mucin] secretion is blocked by equimolar concentrations of nordihydroguiaretic acid ( NDGA ) a `` mixed '' inhibitor of both cyclo- and lipoxygenase pathways of arachidonic acid metabolism . Regulation MUC16 WDR61 3653044 78220 In addition , the stimulatory *effect* of on [mucin] secretion is not altered by FPL-55712 , a receptor antagonist of LTD4 . Regulation MUC17 EPHB2 16983494 1617458 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Regulation MUC17 EPHB2 17237423 1690034 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Regulation MUC17 GPR115 15527548 1331331 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC17 GPR132 15527548 1331320 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC17 GPR87 15527548 1331400 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC17 IL1B 10728932 579460 *Effects* of TNF-alpha and on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC17 IL1B 12869928 1112258 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Regulation MUC17 IL1B 14527933 1185862 *Regulation* of MUC5AC [mucin] secretion and airway surface liquid metabolism by in human bronchial epithelia . Regulation MUC17 RARB 10024510 590864 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Regulation MUC17 SPHK1 19835973 2203027 *regulates* [mucin] production via ERK phosphorylation . Regulation MUC17 SPHK1 19835973 2203105 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Regulation MUC17 TNF 10030839 591852 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Regulation MUC17 TNF 10728932 579459 *Effects* of and IL-1 beta on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC17 TNF 11475334 841809 The *effects* of IL-4 , IL-13 , IL-1beta , IL-8 and on 15-LO isoenzyme mRNA and protein expression , total 15-LO enzyme activity and [mucin] secretion were examined in cultures of normal human bronchial epithelial cells . Regulation MUC17 TNF 1748477 172080 The *effects* of on the FC gamma IBS and [mucin] production could not be attributed to a decreased proliferative rate of the cells , as the cells ' incorporation of 5-bromo-2'-deoxyuridine was unaffected . Regulation MUC17 TNF 7842630 286492 *Effect* of interferon-gamma and on MUC1 [mucin] expression in ovarian carcinoma cell lines . Regulation MUC17 TP63 24895124 2951932 Furthermore , inhibition of mucin-type O-linked glycosylation suppressed the *effect* of on increasing [mucin] production and protecting intestinal epithelial cells from TNF induced apoptosis in colon organ culture . Regulation MUC19 EPHB2 16983494 1617452 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Regulation MUC19 EPHB2 17237423 1690028 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Regulation MUC19 GPR115 15527548 1331052 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC19 GPR132 15527548 1331041 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC19 GPR87 15527548 1331121 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC19 IL1B 10728932 579454 *Effects* of TNF-alpha and on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC19 IL1B 12869928 1112255 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Regulation MUC19 IL1B 14527933 1185859 *Regulation* of MUC5AC [mucin] secretion and airway surface liquid metabolism by in human bronchial epithelia . Regulation MUC19 RARB 10024510 590861 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Regulation MUC19 SPHK1 19835973 2203024 *regulates* [mucin] production via ERK phosphorylation . Regulation MUC19 SPHK1 19835973 2203099 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Regulation MUC19 TNF 10030839 591849 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Regulation MUC19 TNF 10728932 579453 *Effects* of and IL-1 beta on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC19 TNF 11475334 841800 The *effects* of IL-4 , IL-13 , IL-1beta , IL-8 and on 15-LO isoenzyme mRNA and protein expression , total 15-LO enzyme activity and [mucin] secretion were examined in cultures of normal human bronchial epithelial cells . Regulation MUC19 TNF 1748477 172077 The *effects* of on the FC gamma IBS and [mucin] production could not be attributed to a decreased proliferative rate of the cells , as the cells ' incorporation of 5-bromo-2'-deoxyuridine was unaffected . Regulation MUC19 TNF 7842630 286486 *Effect* of interferon-gamma and on MUC1 [mucin] expression in ovarian carcinoma cell lines . Regulation MUC19 TP63 24895124 2951929 Furthermore , inhibition of mucin-type O-linked glycosylation suppressed the *effect* of on increasing [mucin] production and protecting intestinal epithelial cells from TNF induced apoptosis in colon organ culture . Regulation MUC2 EPHB2 16983494 1617472 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Regulation MUC2 EPHB2 17237423 1690048 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Regulation MUC2 GPR115 15527548 1331983 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC2 GPR132 15527548 1331972 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC2 GPR87 15527548 1332052 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC2 IL1B 10728932 579478 *Effects* of TNF-alpha and on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC2 IL1B 10903904 713417 This study demonstrates for the first time the *effects* of on the regulation of protein production as well as [MUC2] gene transcription in cultured human airway epithelial cells . Regulation MUC2 IL1B 12482999 1024676 These results suggest that the mediated MUC2 gene expression and mucin secretion in NCI-H292 cells are regulated through activation of the PKC-MEK/ERK pathway , and that PI3K is also *involved* in the IL-1beta mediated [MUC2] gene expression and mucin secretion . Regulation MUC2 IL1B 12869928 1112265 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Regulation MUC2 IL1B 14527933 1185869 *Regulation* of MUC5AC [mucin] secretion and airway surface liquid metabolism by in human bronchial epithelia . Regulation MUC2 IL1B 20873538 2326415 To demonstrate the *effects* of on [MUC2/MUC5B] gene expression in cultured human nasal epithelial cells . Regulation MUC2 MUC16 12482999 1024671 These results suggest that the IL-1beta mediated MUC2 gene expression and secretion in NCI-H292 cells are regulated through activation of the PKC-MEK/ERK pathway , and that PI3K is also *involved* in the IL-1beta mediated [MUC2] gene expression and mucin secretion . Regulation MUC2 MUC16 16816167 1740104 Expression of antigen MUC1 and down *regulation* of [MUC2] are associated with adverse prognosis in colorectal cancer ( CRC ) , but their prognostic significance with respect to differing DNA mis- match repair (MMR) status is poorly understood . Regulation MUC2 RARB 10024510 590871 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Regulation MUC2 SPHK1 19835973 2203034 *regulates* [mucin] production via ERK phosphorylation . Regulation MUC2 SPHK1 19835973 2203119 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Regulation MUC2 TNF 10030839 591859 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Regulation MUC2 TNF 10728932 579477 *Effects* of and IL-1 beta on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC2 TNF 10858016 704655 Immunocytochemistry and Western blotting confirmed *effects* on [MUC2] and MUC5AC on the protein levels . Regulation MUC2 TNF 11475334 841830 The *effects* of IL-4 , IL-13 , IL-1beta , IL-8 and on 15-LO isoenzyme mRNA and protein expression , total 15-LO enzyme activity and [mucin] secretion were examined in cultures of normal human bronchial epithelial cells . Regulation MUC2 TNF 12848848 1109124 These findings sustain a novel phenomenon that [MUC2] mRNA expression is differently *controlled* by IL-4 , IL-13 , or in LS174T and HT29 cells , whereas the mitogen activated protein kinase pathway plays a role in the MUC2 mRNA expression induced by those cytokines in both cell lines . Regulation MUC2 TNF 1748477 172087 The *effects* of on the FC gamma IBS and [mucin] production could not be attributed to a decreased proliferative rate of the cells , as the cells ' incorporation of 5-bromo-2'-deoxyuridine was unaffected . Regulation MUC2 TNF 18507686 1958435 Taken together , it seems likely that *plays* a role in [MUC2] expression via CDX2 upregulation in the bile ducts with chronic cholangitis and goblet cell metaplasia . Regulation MUC2 TNF 7842630 286506 *Effect* of interferon-gamma and on MUC1 [mucin] expression in ovarian carcinoma cell lines . Regulation MUC2 TP63 24895124 2951939 Furthermore , inhibition of mucin-type O-linked glycosylation suppressed the *effect* of on increasing [mucin] production and protecting intestinal epithelial cells from TNF induced apoptosis in colon organ culture . Regulation MUC20 EPHB2 16983494 1617462 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Regulation MUC20 EPHB2 17237423 1690038 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Regulation MUC20 GPR115 15527548 1331517 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC20 GPR132 15527548 1331506 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC20 GPR87 15527548 1331586 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC20 IL1B 10728932 579464 *Effects* of TNF-alpha and on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC20 IL1B 12869928 1112260 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Regulation MUC20 IL1B 14527933 1185864 *Regulation* of MUC5AC [mucin] secretion and airway surface liquid metabolism by in human bronchial epithelia . Regulation MUC20 RARB 10024510 590866 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Regulation MUC20 SPHK1 19835973 2203029 *regulates* [mucin] production via ERK phosphorylation . Regulation MUC20 SPHK1 19835973 2203109 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Regulation MUC20 TNF 10030839 591854 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Regulation MUC20 TNF 10728932 579463 *Effects* of and IL-1 beta on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC20 TNF 11475334 841815 The *effects* of IL-4 , IL-13 , IL-1beta , IL-8 and on 15-LO isoenzyme mRNA and protein expression , total 15-LO enzyme activity and [mucin] secretion were examined in cultures of normal human bronchial epithelial cells . Regulation MUC20 TNF 1748477 172082 The *effects* of on the FC gamma IBS and [mucin] production could not be attributed to a decreased proliferative rate of the cells , as the cells ' incorporation of 5-bromo-2'-deoxyuridine was unaffected . Regulation MUC20 TNF 7842630 286496 *Effect* of interferon-gamma and on MUC1 [mucin] expression in ovarian carcinoma cell lines . Regulation MUC20 TP63 24895124 2951934 Furthermore , inhibition of mucin-type O-linked glycosylation suppressed the *effect* of on increasing [mucin] production and protecting intestinal epithelial cells from TNF induced apoptosis in colon organ culture . Regulation MUC21 EPHB2 16983494 1617460 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Regulation MUC21 EPHB2 17237423 1690036 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Regulation MUC21 GPR115 15527548 1331424 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC21 GPR132 15527548 1331413 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC21 GPR87 15527548 1331493 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC21 IL1B 10728932 579462 *Effects* of TNF-alpha and on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC21 IL1B 12869928 1112259 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Regulation MUC21 IL1B 14527933 1185863 *Regulation* of MUC5AC [mucin] secretion and airway surface liquid metabolism by in human bronchial epithelia . Regulation MUC21 RARB 10024510 590865 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Regulation MUC21 SPHK1 19835973 2203028 *regulates* [mucin] production via ERK phosphorylation . Regulation MUC21 SPHK1 19835973 2203107 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Regulation MUC21 TNF 10030839 591853 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Regulation MUC21 TNF 10728932 579461 *Effects* of and IL-1 beta on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC21 TNF 11475334 841812 The *effects* of IL-4 , IL-13 , IL-1beta , IL-8 and on 15-LO isoenzyme mRNA and protein expression , total 15-LO enzyme activity and [mucin] secretion were examined in cultures of normal human bronchial epithelial cells . Regulation MUC21 TNF 1748477 172081 The *effects* of on the FC gamma IBS and [mucin] production could not be attributed to a decreased proliferative rate of the cells , as the cells ' incorporation of 5-bromo-2'-deoxyuridine was unaffected . Regulation MUC21 TNF 7842630 286494 *Effect* of interferon-gamma and on MUC1 [mucin] expression in ovarian carcinoma cell lines . Regulation MUC21 TP63 24895124 2951933 Furthermore , inhibition of mucin-type O-linked glycosylation suppressed the *effect* of on increasing [mucin] production and protecting intestinal epithelial cells from TNF induced apoptosis in colon organ culture . Regulation MUC22 EPHB2 16983494 1617464 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Regulation MUC22 EPHB2 17237423 1690040 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Regulation MUC22 GPR115 15527548 1331611 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC22 GPR132 15527548 1331600 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC22 GPR87 15527548 1331680 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC22 IL1B 10728932 579466 *Effects* of TNF-alpha and on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC22 IL1B 12869928 1112261 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Regulation MUC22 IL1B 14527933 1185865 *Regulation* of MUC5AC [mucin] secretion and airway surface liquid metabolism by in human bronchial epithelia . Regulation MUC22 RARB 10024510 590867 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Regulation MUC22 SPHK1 19835973 2203030 *regulates* [mucin] production via ERK phosphorylation . Regulation MUC22 SPHK1 19835973 2203111 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Regulation MUC22 TNF 10030839 591855 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Regulation MUC22 TNF 10728932 579465 *Effects* of and IL-1 beta on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC22 TNF 11475334 841818 The *effects* of IL-4 , IL-13 , IL-1beta , IL-8 and on 15-LO isoenzyme mRNA and protein expression , total 15-LO enzyme activity and [mucin] secretion were examined in cultures of normal human bronchial epithelial cells . Regulation MUC22 TNF 1748477 172083 The *effects* of on the FC gamma IBS and [mucin] production could not be attributed to a decreased proliferative rate of the cells , as the cells ' incorporation of 5-bromo-2'-deoxyuridine was unaffected . Regulation MUC22 TNF 7842630 286498 *Effect* of interferon-gamma and on MUC1 [mucin] expression in ovarian carcinoma cell lines . Regulation MUC22 TP63 24895124 2951935 Furthermore , inhibition of mucin-type O-linked glycosylation suppressed the *effect* of on increasing [mucin] production and protecting intestinal epithelial cells from TNF induced apoptosis in colon organ culture . Regulation MUC4 EPHB2 10980611 731544 *dependent* regulation of sialomucin complex/rat [Muc4] in mammary epithelial cells . Regulation MUC4 EPHB2 16983494 1617474 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Regulation MUC4 EPHB2 17237423 1690050 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Regulation MUC4 FOXA1 17553805 1773811 The human mucin [MUC4] is transcriptionally *regulated* by caudal related homeobox , hepatocyte nuclear factors , , and GATA endodermal transcription factors in epithelial cancer cells . Regulation MUC4 FOXA1 17553805 1773820 Experiments using small interfering RNA , cell co-transfection , and site directed mutagenesis indicated that [MUC4] is *regulated* at the transcriptional level by CDX-1 and -2 , HNF-1 alpha and -1 beta , , HNF-4 alpha and -4 gamma , and GATA-4 , -5 , and -6 factors in a cell-specific manner . Regulation MUC4 GPR115 15527548 1332076 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC4 GPR132 15527548 1332065 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC4 GPR87 15527548 1332145 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC4 IL1B 10728932 579480 *Effects* of TNF-alpha and on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC4 IL1B 12869928 1112266 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Regulation MUC4 IL1B 14527933 1185870 *Regulation* of MUC5AC [mucin] secretion and airway surface liquid metabolism by in human bronchial epithelia . Regulation MUC4 MUC16 17891050 1839861 These results suggest that the [MUC4] gene is expressed in the nasal polyps and that glucocorticoid can *control* the expression of the MUC4 gene and glycoprotein synthesis . Regulation MUC4 RARB 10024510 590872 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Regulation MUC4 SPHK1 19835973 2203035 *regulates* [mucin] production via ERK phosphorylation . Regulation MUC4 SPHK1 19835973 2203121 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Regulation MUC4 TNF 10030839 591860 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Regulation MUC4 TNF 10728932 579479 *Effects* of and IL-1 beta on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC4 TNF 11475334 841833 The *effects* of IL-4 , IL-13 , IL-1beta , IL-8 and on 15-LO isoenzyme mRNA and protein expression , total 15-LO enzyme activity and [mucin] secretion were examined in cultures of normal human bronchial epithelial cells . Regulation MUC4 TNF 1748477 172088 The *effects* of on the FC gamma IBS and [mucin] production could not be attributed to a decreased proliferative rate of the cells , as the cells ' incorporation of 5-bromo-2'-deoxyuridine was unaffected . Regulation MUC4 TNF 7842630 286508 *Effect* of interferon-gamma and on MUC1 [mucin] expression in ovarian carcinoma cell lines . Regulation MUC4 TP63 24895124 2951940 Furthermore , inhibition of mucin-type O-linked glycosylation suppressed the *effect* of on increasing [mucin] production and protecting intestinal epithelial cells from TNF induced apoptosis in colon organ culture . Regulation MUC5AC ALOX5 11324902 807353 These results suggest that the cyclooxygenase and <5-lipoxygenase> metabolic pathways *play* little or no role in the release of [MUC5AC] from human airways . Regulation MUC5AC CHI3L1 23994362 2856081 In this study , we sought to explore the *effect* of on [mucin5AC (MUC5AC)] production in chronic inflammatory airway diseases and the potential signaling pathways involved in this process . Regulation MUC5AC EPHB2 17237423 1690052 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of [MUC5AC] mucin transcription by Streptococcus pneumoniae . Regulation MUC5AC EPHB2 22610099 2619882 We previously reported that S. pneumoniae up-regulates [MUC5AC] expression in a MAPK *dependent* manner . Regulation MUC5AC EPHB2 22610099 2619895 Collectively , these data demonstrate that PDE4B mediates *dependent* up-regulation of mucin [MUC5AC] by S. pneumoniae by inhibiting cAMP-PKA dependent MKP-1 pathway . Regulation MUC5AC GPR115 15985706 1428783 [Gastric mucin] secretion in *response* to beta-adrenergic activation is mediated by SRC kinase dependent epidermal growth factor receptor transactivation . Regulation MUC5AC GPR132 15985706 1428772 [Gastric mucin] secretion in *response* to beta-adrenergic activation is mediated by SRC kinase dependent epidermal growth factor receptor transactivation . Regulation MUC5AC GPR87 15985706 1428852 [Gastric mucin] secretion in *response* to beta-adrenergic activation is mediated by SRC kinase dependent epidermal growth factor receptor transactivation . Regulation MUC5AC IL1B 14527933 1185871 *Regulation* of [MUC5AC] mucin secretion and airway surface liquid metabolism by in human bronchial epithelia . Regulation MUC5AC MUC16 16773182 1572872 [MUC5AC] gene *regulation* in pancreatic cancer cells . Regulation MUC5AC PDE4B 22610099 2619893 Moreover , we show that *plays* a critical role in [MUC5AC] induction . Regulation MUC5AC SPHK1 19835973 2203146 These results suggest that is *involved* in [MUC5AC] production induced by IL-13 upstream of ERK1/2 phosphorylation , and independent of STAT6 phosphorylation . Regulation MUC5AC TNF 10858016 704656 Immunocytochemistry and Western blotting confirmed *effects* on MUC2 and [MUC5AC] on the protein levels . Regulation MUC5AC TNF 11282555 799125 To determine the *effect* of IL-6 and on [MUC5AC] and MUC5B secretion we have used HT29-MTX goblet cells , which secrete both types of mucins . Regulation MUC5AC TNF 15513533 1328323 We then examined whether induces MUC5AC gene expression and whether extracellular signal regulated kinase ( ERK ) *plays* a role in TNF-alpha induced [MUC5AC] gene expression in cultured human nasal polyp epithelial cells . Regulation MUC5B IL1B 20873538 2326416 To demonstrate the *effects* of on [MUC2/MUC5B] gene expression in cultured human nasal epithelial cells . Regulation MUC5B SPHK1 21418911 2405598 To explore the *effects* of on [mucin (MUC)5AC] overexpression under the induction of tumor necrosis factor-a (TNF-a) . Regulation MUC5B TNF 11282555 799127 To determine the *effect* of IL-6 and on MUC5AC and [MUC5B] secretion we have used HT29-MTX goblet cells , which secrete both types of mucins . Regulation MUC6 EPHB2 16983494 1617476 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Regulation MUC6 EPHB2 17237423 1690054 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Regulation MUC6 GPR115 15527548 1332169 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC6 GPR132 15527548 1332158 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC6 GPR87 15527548 1332238 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC6 IL1B 10728932 579482 *Effects* of TNF-alpha and on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC6 IL1B 12869928 1112267 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Regulation MUC6 IL1B 14527933 1185872 *Regulation* of MUC5AC [mucin] secretion and airway surface liquid metabolism by in human bronchial epithelia . Regulation MUC6 RARB 10024510 590873 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Regulation MUC6 SPHK1 19835973 2203036 *regulates* [mucin] production via ERK phosphorylation . Regulation MUC6 SPHK1 19835973 2203123 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Regulation MUC6 TNF 10030839 591861 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Regulation MUC6 TNF 10728932 579481 *Effects* of and IL-1 beta on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC6 TNF 11475334 841836 The *effects* of IL-4 , IL-13 , IL-1beta , IL-8 and on 15-LO isoenzyme mRNA and protein expression , total 15-LO enzyme activity and [mucin] secretion were examined in cultures of normal human bronchial epithelial cells . Regulation MUC6 TNF 1748477 172089 The *effects* of on the FC gamma IBS and [mucin] production could not be attributed to a decreased proliferative rate of the cells , as the cells ' incorporation of 5-bromo-2'-deoxyuridine was unaffected . Regulation MUC6 TNF 7842630 286510 *Effect* of interferon-gamma and on MUC1 [mucin] expression in ovarian carcinoma cell lines . Regulation MUC6 TP63 24895124 2951941 Furthermore , inhibition of mucin-type O-linked glycosylation suppressed the *effect* of on increasing [mucin] production and protecting intestinal epithelial cells from TNF induced apoptosis in colon organ culture . Regulation MUC7 EPHB2 16983494 1617478 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Regulation MUC7 EPHB2 17237423 1690056 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Regulation MUC7 GPR115 15527548 1332262 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC7 GPR132 15527548 1332251 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC7 GPR87 15527548 1332331 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC7 IL1B 10728932 579484 *Effects* of TNF-alpha and on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC7 IL1B 12869928 1112268 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Regulation MUC7 IL1B 14527933 1185873 *Regulation* of MUC5AC [mucin] secretion and airway surface liquid metabolism by in human bronchial epithelia . Regulation MUC7 RARB 10024510 590874 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Regulation MUC7 SPHK1 19835973 2203037 *regulates* [mucin] production via ERK phosphorylation . Regulation MUC7 SPHK1 19835973 2203125 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Regulation MUC7 TNF 10030839 591862 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Regulation MUC7 TNF 10728932 579483 *Effects* of and IL-1 beta on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC7 TNF 11475334 841839 The *effects* of IL-4 , IL-13 , IL-1beta , IL-8 and on 15-LO isoenzyme mRNA and protein expression , total 15-LO enzyme activity and [mucin] secretion were examined in cultures of normal human bronchial epithelial cells . Regulation MUC7 TNF 1748477 172090 The *effects* of on the FC gamma IBS and [mucin] production could not be attributed to a decreased proliferative rate of the cells , as the cells ' incorporation of 5-bromo-2'-deoxyuridine was unaffected . Regulation MUC7 TNF 7842630 286512 *Effect* of interferon-gamma and on MUC1 [mucin] expression in ovarian carcinoma cell lines . Regulation MUC7 TP63 24895124 2951942 Furthermore , inhibition of mucin-type O-linked glycosylation suppressed the *effect* of on increasing [mucin] production and protecting intestinal epithelial cells from TNF induced apoptosis in colon organ culture . Regulation MUC8 EPHB2 16983494 1617480 The findings are the first to demonstrate that P. gingivalis LPS detrimental effect on salivary [mucin] synthesis *involves* dependent cPLA2 activation that leads to up-regulation in PAF production and ET-1 generation . Regulation MUC8 EPHB2 17237423 1690058 A novel role for IkappaB kinase (IKK) alpha and IKKbeta in *dependent* up-regulation of MUC5AC [mucin] transcription by Streptococcus pneumoniae . Regulation MUC8 GPR115 15527548 1332355 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC8 GPR132 15527548 1332344 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC8 GPR87 15527548 1332424 Src-kinase dependent epidermal growth factor receptor transactivation in salivary [mucin] secretion in *response* to beta-adrenergic activation . Regulation MUC8 IL1B 10728932 579486 *Effects* of TNF-alpha and on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC8 IL1B 12869928 1112269 To investigate the *role* of the inflammatory cytokine in the regulation of [mucin] secretion by middle ear epithelia . Regulation MUC8 IL1B 14527933 1185874 *Regulation* of MUC5AC [mucin] secretion and airway surface liquid metabolism by in human bronchial epithelia . Regulation MUC8 IL1B 18952062 1989263 Interaction of SOCS3 with NonO attenuates *dependent* [MUC8] gene expression . Regulation MUC8 RARB 10024510 590875 Furthermore these studies suggest that is probably not ( directly ) *involved* in RA-induced [mucin] gene expression . Regulation MUC8 SPHK1 19835973 2203038 *regulates* [mucin] production via ERK phosphorylation . Regulation MUC8 SPHK1 19835973 2203127 To clarify the *role* of in airway [mucin] production , we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium . Regulation MUC8 TNF 10030839 591863 and [mucin] secretion in *response* to or to the cGMP analogue dibutyryl cGMP ( 100 and 500 microM ) was attenuated by the specific PKG inhibitor KT5823 ( 1 microM ) . Regulation MUC8 TNF 10728932 579485 *Effects* of and IL-1 beta on [mucin] , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells . Regulation MUC8 TNF 11475334 841842 The *effects* of IL-4 , IL-13 , IL-1beta , IL-8 and on 15-LO isoenzyme mRNA and protein expression , total 15-LO enzyme activity and [mucin] secretion were examined in cultures of normal human bronchial epithelial cells . Regulation MUC8 TNF 1748477 172091 The *effects* of on the FC gamma IBS and [mucin] production could not be attributed to a decreased proliferative rate of the cells , as the cells ' incorporation of 5-bromo-2'-deoxyuridine was unaffected . Regulation MUC8 TNF 7842630 286514 *Effect* of interferon-gamma and on MUC1 [mucin] expression in ovarian carcinoma cell lines . Regulation MUC8 TP63 24895124 2951943 Furthermore , inhibition of mucin-type O-linked glycosylation suppressed the *effect* of on increasing [mucin] production and protecting intestinal epithelial cells from TNF induced apoptosis in colon organ culture . Regulation MUCL1 PARM1 24085821 2858010 ( prostate androgen *regulated* [mucin-like protein 1] ) has been implicated in cell differentiation and cell survival in nonovarian cells , but little is known about PARM1 in the ovary . Regulation MX2 CCL5 21130742 2372843 Cxcl10 , Mx1 , Ifi44 , Ifi203 , Iigp2 and Rtp4 were dominantly regulated by IPS-1 , by TLR3 , and Rsad2 , [Mx2] and Cmpk2 were *regulated* by TLR3 and IPS-1 . Regulation MX2 MAVS 21130742 2372845 Cxcl10 , Mx1 , Ifi44 , Ifi203 , Iigp2 and Rtp4 were dominantly regulated by IPS-1 , Ccl5 by TLR3 , and Rsad2 , [Mx2] and Cmpk2 were *regulated* by TLR3 and . Regulation MX2 TLR3 21130742 2372844 Cxcl10 , Mx1 , Ifi44 , Ifi203 , Iigp2 and Rtp4 were dominantly regulated by IPS-1 , Ccl5 by , and Rsad2 , [Mx2] and Cmpk2 were *regulated* by TLR3 and IPS-1 . Regulation MYB CCND1 15687240 1395455 The results suggest that [c-Myb] activity is directly *regulated* by and CDKs and imply that c-Myb activity is regulated during the cell cycle in hematopoietic cells . Regulation MYBL2 CCND1 10645009 661762 *Regulation* of [B-Myb] activity by . Regulation MYBL2 CCND1 10645009 661763 Our work identifies B-Myb as an interacting partner for cyclin D1 and suggest that the activity of [B-Myb] during the cell cycle is *controlled* by the antagonistic effects of and A . Regulation MYBL2 CCND1 10871850 708316 We have previously shown that [B-Myb] activity is cell cycle regulated and it is *controlled* by the antagonistic effects of and A . Regulation MYBL2 CCND1 12404122 1009694 *regulation* of [B-myb] activity in early stages of neuroblastoma differentiation . Regulation MYBL2 MIP 17098733 1676153 *regulates* the expression of [B-Myb] and the induction of cyclin A , cyclin B , and CDK1 . Regulation MYC AXIN2 24299953 2894679 These findings suggest that nuclear functions as a rheostat to *control* [MYC] expression in response to Wnt/ß-catenin signaling . Regulation MYC CAPN8 12054425 951047 Evidence for *involvement* of in [c-Myc] proteolysis in vivo . Regulation MYC EPHB2 15811177 1397492 Therefore , our main aim was to examine the levels of MAPK in Myc transformed cells in light of the *roles* of in cell cycle and control of [Myc] protein levels . Regulation MYC EPHB2 16596619 1550265 These data suggest that an increase in [c-Myc] phosphorylation in *response* to prolonged phosphorylation negatively auto-regulates c-Myc gene expression , leading to the suppression of its target gene expression and cell cycle block . Regulation MYC EPHB2 17699159 1800619 Thus Erf provides a direct link between the signaling and the transcriptional *regulation* of [c-Myc] and suggests that RAS/ERK attenuation actively regulates cell fate . Regulation MYC EPHB2 19258428 2045258 In this article , we investigate whether inhibition , by the MEK/ERK inhibitor U0126 , *affects* [c-Myc] protein level and growth of RMS tumor in an in vivo xenograft model . Regulation MYC MAP2K6 19258428 2045264 In this article , we investigate whether inhibition , by the MEK/ERK inhibitor U0126 , *affects* [c-Myc] protein level and growth of RMS tumor in an in vivo xenograft model . Regulation MYC MSX1 15911613 1433294 and rapamycin *act* additively on [Gln3-Myc13] phosphorylation , but MSX clearly predominates . Regulation MYCN EPHB2 21698133 2446723 SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the *effects* of MKP3 and on [N-Myc] protein stability . Regulation MYCN TNF 9690515 523048 [MycN] also increased cell death in *response* to TRAIL and , suggesting that enforced MYCN expression in general increases the susceptibility of neuroblastoma cells towards a variety of death stimuli . Regulation MYCN TNFSF10 9690515 523049 [MycN] also increased cell death in *response* to and TNFalpha , suggesting that enforced MYCN expression in general increases the susceptibility of neuroblastoma cells towards a variety of death stimuli . Regulation MYD88 IL1B 11976320 953998 CaMKKc and Akt overexpression decreases IRAK1 mediated NF-kappaB activity and its association with [MyD88] in *response* to stimulation . Regulation MYD88 SELL 11842086 929201 We show that HSP70 induces interleukin-12 (IL-12) and endothelial ( ELAM-1 ) promoters in macrophages and that this is *controlled* by [MyD88] and TRAF6 . Regulation MYD88 TLR7 16239509 1471062 We also determined that [MyD88] , IRAK , TRAF6 , and Toll interacting protein (Tollip) , but not TIRAP , were involved in the mediated *response* to P. aeruginosa in HAECs . Regulation MYD88 TNF 12763043 1093842 The results demonstrated three patterns of gene expression : the TLR2 and myeloid differentiation factor 88 ( [MyD88] ) gene expressions were induced in AM in *response* to lipopolysaccharide (LPS) , interleukin (IL)-1beta , or or in the lung tissue of an LPS induced acute lung injury model ; Regulation MYEF2 PGC 15111488 1241170 From these data , it appears that HDAC5 , , and p38 *regulate* [MEF-2] and could be potential targets for modulating GLUT4 expression . Regulation MYH1 TGM2 22063397 1034611 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH10 TGM2 22063397 1034618 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH11 TGM2 22063397 1034625 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH13 TGM2 22063397 1034632 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH14 TGM2 22063397 1034590 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH15 TGM2 22063397 1034604 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH16 CA2 10580427 570068 Phosphopeptide mapping suggested that the same peptide was phosphorylated under both PMA and glyceraldehyde stimulation , which further extends our previous study of the Ca2+ dependent phosphorylation of this protein ( Wilson JR , Ludowyke RI , Biden TJ : Nutrient stimulation results in a rapid *dependent* threonine phosphorylation of [myosin heavy chain] in rat pancreatic islets and RINm5F cells . Regulation MYH16 EDN1 1567402 186889 The *effect* of on cardiac [myosin heavy chain] gene expression was examined using an isolated neonatal rat myocardial cell culture system . Regulation MYH16 EGR1 2071571 162707 , a serum-inducible zinc finger protein , *regulates* transcription of the rat cardiac [alpha-myosin heavy chain] gene . Regulation MYH16 GATA4 8007990 258449 *regulates* cardiac muscle-specific expression of the [alpha-myosin heavy-chain] gene . Regulation MYH16 GATA5 10212267 607819 is *involved* in leukemia inhibitory factor-responsive transcription of the [beta-myosin heavy chain] gene in cardiac myocytes . Regulation MYH16 GATA6 16293227 1502696 To address the potential mechanisms by which CHF1/Hey2 regulates vascular smooth-muscle phenotype switching , we investigated the effect of CHF1/Hey2 on *dependent* smooth-muscle [myosin heavy chain] promoter activity . Regulation MYH16 GRAP2 15483225 1366831 Static stretch promotes MEF2A nuclear translocation and expression of neonatal [myosin heavy chain] in C2C12 myocytes in a calcineurin- and *dependent* manner . Regulation MYH16 HEY2 16293227 1502697 To address the potential mechanisms by which CHF1/Hey2 regulates vascular smooth-muscle phenotype switching , we investigated the *effect* of on GATA-6 dependent smooth-muscle [myosin heavy chain] promoter activity . Regulation MYH16 HRAS 19625607 2142895 Different *roles* of for regulation of [myosin heavy chain] promoters in satellite cell derived muscle cell culture during proliferation and differentiation . Regulation MYH16 KLF15 24680826 2935095 *regulates* slow [myosin heavy chain] expression through NFATc1 in C2C12 myotubes . Regulation MYH16 MIR27A 21149577 2378428 *regulates* beta cardiac [myosin heavy chain] gene expression by targeting thyroid hormone receptor beta1 in neonatal rat ventricular myocytes . Regulation MYH16 MMP9 10937947 580708 Altered balance between matrix gelatinases ( MMP-2 and MMP-9 ) and their tissue inhibitors in human dilated cardiomyopathy : potential *role* of in [myosin-heavy chain] degradation . Regulation MYH16 MSH2 20223032 1506520 We reasoned that because of the clinical similarity of a subset of HNPCC patients to those described with MYH mutations and the *role* of the complex in the activation of [MYH] protein that MYH mutations may account for a small proportion of HNPCC patients . Regulation MYH16 MSH6 20223032 1506521 We reasoned that because of the clinical similarity of a subset of HNPCC patients to those described with MYH mutations and the *role* of the complex in the activation of [MYH] protein that MYH mutations may account for a small proportion of HNPCC patients . Regulation MYH16 MSTN 22910409 2672254 Interestingly , Mstn knockout led to a shift of Myh towards faster isoforms , suggesting an inhibitory *role* of in fast [Myh] expression . Regulation MYH16 MSTN 22910409 2672268 Importantly , both Mstn antibody and soluble activin type 2B receptor inhibited slow Myh7 and promoted fast Myh4 expression , indicating that acts through canonical activin receptor to *regulate* the expression of [Myh] genes . Regulation MYH16 MTOR 22648621 2604913 Leucine induces myofibrillar protein accretion in cultured skeletal muscle through *dependent* and -independent control of [myosin heavy chain] mRNA levels . Regulation MYH16 MYEF2 8366095 229298 Myocyte-specific enhancer binding factor ( ) *regulates* alpha-cardiac [myosin heavy chain] gene expression in vitro and in vivo . Regulation MYH16 MYEF2 8449897 214072 *Role* of myocyte-specific enhancer binding factor ( ) in transcriptional regulation of the alpha-cardiac [myosin heavy chain] gene . Regulation MYH16 PITX2 21727215 2476149 *regulates* [myosin heavy chain] isoform expression and multi-innervation in extraocular muscle . Regulation MYH16 RHO 16397143 1520213 All trans-retinoic acid treatment of A404 cells induced a strong increase in LPP , as well as SM alpha-actin , SM [myosin heavy chain] , and smoothelin mRNA levels , in a *dependent* manner . Regulation MYH16 SRF 11133226 769072 Nitric oxide *regulates* smooth-muscle-specific [myosin heavy chain] gene expression at the transcriptional level-possible role of and YY1 through CArG element . Regulation MYH16 TGM1 22063397 1034596 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH16 TGM2 22063397 1034597 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH16 TGM3 22063397 1034598 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH16 TGM4 22063397 1034599 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH16 TGM5 22063397 1034600 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH16 TGM6 22063397 1034601 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH16 TGM7 22063397 1034602 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH16 THRB 21149577 2378427 MicroRNA-27a *regulates* beta cardiac [myosin heavy chain] gene expression by targeting in neonatal rat ventricular myocytes . Regulation MYH16 USF1 12063293 953326 *Role* of phosphorylation on cardiac [alpha-myosin heavy chain] promoter activity . Regulation MYH16 YY1 11133226 769073 Nitric oxide *regulates* smooth-muscle-specific [myosin heavy chain] gene expression at the transcriptional level-possible role of SRF and through CArG element . Regulation MYH2 TGM2 22063397 1034639 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH3 CA2 10580427 570075 Phosphopeptide mapping suggested that the same peptide was phosphorylated under both PMA and glyceraldehyde stimulation , which further extends our previous study of the Ca2+ dependent phosphorylation of this protein ( Wilson JR , Ludowyke RI , Biden TJ : Nutrient stimulation results in a rapid *dependent* threonine phosphorylation of [myosin heavy chain] in rat pancreatic islets and RINm5F cells . Regulation MYH3 EDN1 1567402 186896 The *effect* of on cardiac [myosin heavy chain] gene expression was examined using an isolated neonatal rat myocardial cell culture system . Regulation MYH3 EGR1 2071571 162714 , a serum-inducible zinc finger protein , *regulates* transcription of the rat cardiac [alpha-myosin heavy chain] gene . Regulation MYH3 GATA4 8007990 258456 *regulates* cardiac muscle-specific expression of the [alpha-myosin heavy-chain] gene . Regulation MYH3 GATA5 10212267 607827 is *involved* in leukemia inhibitory factor-responsive transcription of the [beta-myosin heavy chain] gene in cardiac myocytes . Regulation MYH3 GATA6 16293227 1502710 To address the potential mechanisms by which CHF1/Hey2 regulates vascular smooth-muscle phenotype switching , we investigated the effect of CHF1/Hey2 on *dependent* smooth-muscle [myosin heavy chain] promoter activity . Regulation MYH3 GRAP2 15483225 1366839 Static stretch promotes MEF2A nuclear translocation and expression of neonatal [myosin heavy chain] in C2C12 myocytes in a calcineurin- and *dependent* manner . Regulation MYH3 HEY2 16293227 1502711 To address the potential mechanisms by which CHF1/Hey2 regulates vascular smooth-muscle phenotype switching , we investigated the *effect* of on GATA-6 dependent smooth-muscle [myosin heavy chain] promoter activity . Regulation MYH3 HRAS 19625607 2142902 Different *roles* of for regulation of [myosin heavy chain] promoters in satellite cell derived muscle cell culture during proliferation and differentiation . Regulation MYH3 KLF15 24680826 2935102 *regulates* slow [myosin heavy chain] expression through NFATc1 in C2C12 myotubes . Regulation MYH3 MIR27A 21149577 2378443 *regulates* beta cardiac [myosin heavy chain] gene expression by targeting thyroid hormone receptor beta1 in neonatal rat ventricular myocytes . Regulation MYH3 MMP9 10937947 580715 Altered balance between matrix gelatinases ( MMP-2 and MMP-9 ) and their tissue inhibitors in human dilated cardiomyopathy : potential *role* of in [myosin-heavy chain] degradation . Regulation MYH3 MSH2 20223032 1506534 We reasoned that because of the clinical similarity of a subset of HNPCC patients to those described with MYH mutations and the *role* of the complex in the activation of [MYH] protein that MYH mutations may account for a small proportion of HNPCC patients . Regulation MYH3 MSH6 20223032 1506535 We reasoned that because of the clinical similarity of a subset of HNPCC patients to those described with MYH mutations and the *role* of the complex in the activation of [MYH] protein that MYH mutations may account for a small proportion of HNPCC patients . Regulation MYH3 MSTN 22910409 2672261 Interestingly , Mstn knockout led to a shift of Myh towards faster isoforms , suggesting an inhibitory *role* of in fast [Myh] expression . Regulation MYH3 MSTN 22910409 2672275 Importantly , both Mstn antibody and soluble activin type 2B receptor inhibited slow Myh7 and promoted fast Myh4 expression , indicating that acts through canonical activin receptor to *regulate* the expression of [Myh] genes . Regulation MYH3 MTOR 22648621 2604920 Leucine induces myofibrillar protein accretion in cultured skeletal muscle through *dependent* and -independent control of [myosin heavy chain] mRNA levels . Regulation MYH3 MYEF2 8366095 229305 Myocyte-specific enhancer binding factor ( ) *regulates* alpha-cardiac [myosin heavy chain] gene expression in vitro and in vivo . Regulation MYH3 MYEF2 8449897 214079 *Role* of myocyte-specific enhancer binding factor ( ) in transcriptional regulation of the alpha-cardiac [myosin heavy chain] gene . Regulation MYH3 PITX2 21727215 2476156 *regulates* [myosin heavy chain] isoform expression and multi-innervation in extraocular muscle . Regulation MYH3 RHO 16397143 1520221 All trans-retinoic acid treatment of A404 cells induced a strong increase in LPP , as well as SM alpha-actin , SM [myosin heavy chain] , and smoothelin mRNA levels , in a *dependent* manner . Regulation MYH3 SRF 11133226 769086 Nitric oxide *regulates* smooth-muscle-specific [myosin heavy chain] gene expression at the transcriptional level-possible role of and YY1 through CArG element . Regulation MYH3 TGM1 22063397 1034645 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH3 TGM2 22063397 1034646 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH3 TGM3 22063397 1034647 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH3 TGM4 22063397 1034648 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH3 TGM5 22063397 1034649 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH3 TGM6 22063397 1034650 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH3 TGM7 22063397 1034651 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH3 THRB 21149577 2378442 MicroRNA-27a *regulates* beta cardiac [myosin heavy chain] gene expression by targeting in neonatal rat ventricular myocytes . Regulation MYH3 USF1 12063293 953333 *Role* of phosphorylation on cardiac [alpha-myosin heavy chain] promoter activity . Regulation MYH3 YY1 11133226 769087 Nitric oxide *regulates* smooth-muscle-specific [myosin heavy chain] gene expression at the transcriptional level-possible role of SRF and through CArG element . Regulation MYH4 TGM2 22063397 1034653 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH6 TGM2 22063397 1034660 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH7 TGM2 22063397 1034667 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH8 TGM2 22063397 1034674 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYH9 TGM2 22063397 1034681 Purification of and its *effects* on [myosin heavy chain] and actin of spent hens . Regulation MYL1 CAPN8 2829910 82585 Elucidation of *dependent* phosphorylation of [myosin light chain] in human platelets . Regulation MYL1 CAPN8 3026398 66796 Possible *participation* of in [myosin light chain] phosphorylation of human platelets . Regulation MYL1 EDN2 2183615 131932 In the absence of Ca++ in the buffer medium of myometrial cells , the *effects* of on intracellular Ca++ and [myosin light chain] phosphorylation are attenuated but not abolished . Regulation MYL1 EFNB1 22393061 2593205 Small interfering RNA knockdown of Grip1 , a molecule associated with the Efnb1 intracellular tail , partially eliminated the *effect* of on VSMC contractility and [myosin light chain] phosphorylation . Regulation MYL1 EPHB2 10477763 643334 signaling is independent of CAS/Crk coupling and *regulates* [myosin light chain] phosphorylation leading to actin-myosin assembly during cell migration and cell mediated contraction of a collagen matrix . Regulation MYL1 EPHB2 15665049 1402439 The present study tested the hypothesis that and PKC differentially *regulated* [myosin light chain] phosphatase activity by phosphorylation of myosin phosphatase target protein-1 ( MYPT-1 ) and CPI-17 . Regulation MYL10 CAPN8 2829910 82571 Elucidation of *dependent* phosphorylation of [myosin light chain] in human platelets . Regulation MYL10 CAPN8 3026398 66782 Possible *participation* of in [myosin light chain] phosphorylation of human platelets . Regulation MYL10 EDN2 2183615 131929 In the absence of Ca++ in the buffer medium of myometrial cells , the *effects* of on intracellular Ca++ and [myosin light chain] phosphorylation are attenuated but not abolished . Regulation MYL10 EFNB1 22393061 2593204 Small interfering RNA knockdown of Grip1 , a molecule associated with the Efnb1 intracellular tail , partially eliminated the *effect* of on VSMC contractility and [myosin light chain] phosphorylation . Regulation MYL10 EPHB2 10477763 643333 signaling is independent of CAS/Crk coupling and *regulates* [myosin light chain] phosphorylation leading to actin-myosin assembly during cell migration and cell mediated contraction of a collagen matrix . Regulation MYL10 EPHB2 15665049 1402438 The present study tested the hypothesis that and PKC differentially *regulated* [myosin light chain] phosphatase activity by phosphorylation of myosin phosphatase target protein-1 ( MYPT-1 ) and CPI-17 . Regulation MYL2 CAPN8 2829910 82599 Elucidation of *dependent* phosphorylation of [myosin light chain] in human platelets . Regulation MYL2 CAPN8 3026398 66810 Possible *participation* of in [myosin light chain] phosphorylation of human platelets . Regulation MYL2 EDN2 2183615 131935 In the absence of Ca++ in the buffer medium of myometrial cells , the *effects* of on intracellular Ca++ and [myosin light chain] phosphorylation are attenuated but not abolished . Regulation MYL2 EFNB1 22393061 2593206 Small interfering RNA knockdown of Grip1 , a molecule associated with the Efnb1 intracellular tail , partially eliminated the *effect* of on VSMC contractility and [myosin light chain] phosphorylation . Regulation MYL2 EPHB2 10477763 643335 signaling is independent of CAS/Crk coupling and *regulates* [myosin light chain] phosphorylation leading to actin-myosin assembly during cell migration and cell mediated contraction of a collagen matrix . Regulation MYL2 EPHB2 15665049 1402440 The present study tested the hypothesis that and PKC differentially *regulated* [myosin light chain] phosphatase activity by phosphorylation of myosin phosphatase target protein-1 ( MYPT-1 ) and CPI-17 . Regulation MYL2 F2R 19553659 2116971 Because myosin II is functionally associated with PAR1 , perturbation of *regulated* [myosin II] by CagA may underlie the defect of rear retraction in the hummingbird phenotype . Regulation MYL3 CAPN8 2829910 82613 Elucidation of *dependent* phosphorylation of [myosin light chain] in human platelets . Regulation MYL3 CAPN8 3026398 66824 Possible *participation* of in [myosin light chain] phosphorylation of human platelets . Regulation MYL3 EDN2 2183615 131938 In the absence of Ca++ in the buffer medium of myometrial cells , the *effects* of on intracellular Ca++ and [myosin light chain] phosphorylation are attenuated but not abolished . Regulation MYL3 EFNB1 22393061 2593207 Small interfering RNA knockdown of Grip1 , a molecule associated with the Efnb1 intracellular tail , partially eliminated the *effect* of on VSMC contractility and [myosin light chain] phosphorylation . Regulation MYL3 EPHB2 10477763 643336 signaling is independent of CAS/Crk coupling and *regulates* [myosin light chain] phosphorylation leading to actin-myosin assembly during cell migration and cell mediated contraction of a collagen matrix . Regulation MYL3 EPHB2 15665049 1402441 The present study tested the hypothesis that and PKC differentially *regulated* [myosin light chain] phosphatase activity by phosphorylation of myosin phosphatase target protein-1 ( MYPT-1 ) and CPI-17 . Regulation MYL4 CAPN8 2829910 82627 Elucidation of *dependent* phosphorylation of [myosin light chain] in human platelets . Regulation MYL4 CAPN8 3026398 66838 Possible *participation* of in [myosin light chain] phosphorylation of human platelets . Regulation MYL4 EDN2 2183615 131941 In the absence of Ca++ in the buffer medium of myometrial cells , the *effects* of on intracellular Ca++ and [myosin light chain] phosphorylation are attenuated but not abolished . Regulation MYL4 EFNB1 22393061 2593208 Small interfering RNA knockdown of Grip1 , a molecule associated with the Efnb1 intracellular tail , partially eliminated the *effect* of on VSMC contractility and [myosin light chain] phosphorylation . Regulation MYL4 EPHB2 10477763 643337 signaling is independent of CAS/Crk coupling and *regulates* [myosin light chain] phosphorylation leading to actin-myosin assembly during cell migration and cell mediated contraction of a collagen matrix . Regulation MYL4 EPHB2 15665049 1402442 The present study tested the hypothesis that and PKC differentially *regulated* [myosin light chain] phosphatase activity by phosphorylation of myosin phosphatase target protein-1 ( MYPT-1 ) and CPI-17 . Regulation MYL5 CAPN8 2829910 82641 Elucidation of *dependent* phosphorylation of [myosin light chain] in human platelets . Regulation MYL5 CAPN8 3026398 66852 Possible *participation* of in [myosin light chain] phosphorylation of human platelets . Regulation MYL5 EDN2 2183615 131944 In the absence of Ca++ in the buffer medium of myometrial cells , the *effects* of on intracellular Ca++ and [myosin light chain] phosphorylation are attenuated but not abolished . Regulation MYL5 EFNB1 22393061 2593209 Small interfering RNA knockdown of Grip1 , a molecule associated with the Efnb1 intracellular tail , partially eliminated the *effect* of on VSMC contractility and [myosin light chain] phosphorylation . Regulation MYL5 EPHB2 10477763 643338 signaling is independent of CAS/Crk coupling and *regulates* [myosin light chain] phosphorylation leading to actin-myosin assembly during cell migration and cell mediated contraction of a collagen matrix . Regulation MYL5 EPHB2 15665049 1402443 The present study tested the hypothesis that and PKC differentially *regulated* [myosin light chain] phosphatase activity by phosphorylation of myosin phosphatase target protein-1 ( MYPT-1 ) and CPI-17 . Regulation MYL6 CAPN8 2829910 82655 Elucidation of *dependent* phosphorylation of [myosin light chain] in human platelets . Regulation MYL6 CAPN8 3026398 66866 Possible *participation* of in [myosin light chain] phosphorylation of human platelets . Regulation MYL6 EDN2 2183615 131947 In the absence of Ca++ in the buffer medium of myometrial cells , the *effects* of on intracellular Ca++ and [myosin light chain] phosphorylation are attenuated but not abolished . Regulation MYL6 EFNB1 22393061 2593210 Small interfering RNA knockdown of Grip1 , a molecule associated with the Efnb1 intracellular tail , partially eliminated the *effect* of on VSMC contractility and [myosin light chain] phosphorylation . Regulation MYL6 EPHB2 10477763 643339 signaling is independent of CAS/Crk coupling and *regulates* [myosin light chain] phosphorylation leading to actin-myosin assembly during cell migration and cell mediated contraction of a collagen matrix . Regulation MYL6 EPHB2 15665049 1402444 The present study tested the hypothesis that and PKC differentially *regulated* [myosin light chain] phosphatase activity by phosphorylation of myosin phosphatase target protein-1 ( MYPT-1 ) and CPI-17 . Regulation MYL7 CAPN8 2829910 82557 Elucidation of *dependent* phosphorylation of [myosin light chain] in human platelets . Regulation MYL7 CAPN8 3026398 66768 Possible *participation* of in [myosin light chain] phosphorylation of human platelets . Regulation MYL7 EDN2 2183615 131926 In the absence of Ca++ in the buffer medium of myometrial cells , the *effects* of on intracellular Ca++ and [myosin light chain] phosphorylation are attenuated but not abolished . Regulation MYL7 EFNB1 22393061 2593203 Small interfering RNA knockdown of Grip1 , a molecule associated with the Efnb1 intracellular tail , partially eliminated the *effect* of on VSMC contractility and [myosin light chain] phosphorylation . Regulation MYL7 EPHB2 10477763 643332 signaling is independent of CAS/Crk coupling and *regulates* [myosin light chain] phosphorylation leading to actin-myosin assembly during cell migration and cell mediated contraction of a collagen matrix . Regulation MYL7 EPHB2 15665049 1402437 The present study tested the hypothesis that and PKC differentially *regulated* [myosin light chain] phosphatase activity by phosphorylation of myosin phosphatase target protein-1 ( MYPT-1 ) and CPI-17 . Regulation MYL9 CAPN8 2829910 82543 Elucidation of *dependent* phosphorylation of [myosin light chain] in human platelets . Regulation MYL9 CAPN8 3026398 66754 Possible *participation* of in [myosin light chain] phosphorylation of human platelets . Regulation MYL9 EDN2 2183615 131923 In the absence of Ca++ in the buffer medium of myometrial cells , the *effects* of on intracellular Ca++ and [myosin light chain] phosphorylation are attenuated but not abolished . Regulation MYL9 EFNB1 22393061 2593202 Small interfering RNA knockdown of Grip1 , a molecule associated with the Efnb1 intracellular tail , partially eliminated the *effect* of on VSMC contractility and [myosin light chain] phosphorylation . Regulation MYL9 EPHB2 10477763 643331 signaling is independent of CAS/Crk coupling and *regulates* [myosin light chain] phosphorylation leading to actin-myosin assembly during cell migration and cell mediated contraction of a collagen matrix . Regulation MYL9 EPHB2 15665049 1402436 The present study tested the hypothesis that and PKC differentially *regulated* [myosin light chain] phosphatase activity by phosphorylation of myosin phosphatase target protein-1 ( MYPT-1 ) and CPI-17 . Regulation MYLIP CCND1 22260523 2551335 MiRNA transfection and luciferase assay confirmed that bcl-2 was *regulated* by miR-16 and [miR-143] , was modulated by miR-16 . Regulation MYLIP CCND1 22912826 2657485 [miR-338-3p] can directly *regulate* CyclinD1 expression through binding to the region , mainly at nt 2397-2403 . Regulation MYLIP CDKN1C 24308935 2877786 By siRNA technology , we also demonstrated that SOD-2 is the antioxidant enzyme involved in the control of [miR-221/222-driven] posttranscriptional *regulation* . Regulation MYLIP CTGF 23390502 2739731 In addition [miR-145] *regulates* glioma cell migration by targeting which downregulates SPARC expression . Regulation MYLIP EFNB1 20308325 2244640 Furthermore , we showed that [miR-124] is itself *regulated* by reverse signaling , thus revealing the existence of a mutually repressive interaction between ephrin-B1 and this microRNA ( miRNA ) . Regulation MYLIP EPHB2 19438724 2090446 These results reveal that the signal *regulates* [miR-221/222] expression , and that these miRNAs might contribute to NGF dependent cell survival in PC12 cells . Regulation MYLIP EPHB2 23533157 2804075 Mechanistically , *dependent* induction of [miR-18a*] directly represses expression of DLL3 , an autocrine inhibitor of NOTCH , thus enhancing the level of activated NOTCH-1 . Regulation MYLIP FHL1 18801012 2021102 We also demonstrate that induction of [miR395] is *controlled* by , a key transcription factor in the sulphur assimilation pathway . Regulation MYLIP FHL1 23628900 2804960 siRNA targeted against Fhl-1 was used to investigate the *effect* of on [miR-206] . Regulation MYLIP IL1B 19714579 2139311 We tested the *effects* of on [miR-140] expression . Regulation MYLIP IL1B 19714579 2139316 The reduction in [miR-140] expression in OA cartilage and in *response* to may contribute to the abnormal gene expression pattern characteristic of OA . Regulation MYLIP KLF9 24349493 2881285 Furthermore , we performed luciferase reporter assay and showed that [miR-140] mimic directly *regulates* , thereby establishing and validating an example coregulatory network involving NR2F1 , miR-140 , and Klf9 . Regulation MYLIP MYH16 22666483 2611142 In rodent heart , and its micro-RNA miR-208a *regulate* the expression of beta-MyHC and of its intronic [miR-208b] . Regulation MYLIP MYH3 22666483 2611149 In rodent heart , and its micro-RNA miR-208a *regulate* the expression of beta-MyHC and of its intronic [miR-208b] . Regulation MYLIP NR2F1 24349493 2881284 Based on this , we performed chromatin-immunoprecipitation followed by qRT-PCR and confirmed that directly binds and *regulates* both [miR-140] and Klf9 in vivo . Regulation MYLIP TNF 17911593 1803695 Altogether , our data suggest that the *dependent* regulation of [miR-155] and miR-125b may be implicated in the response to endotoxin shock , thus offering new targets for drug design . Regulation MYLIP TNF 21611196 2436185 These results indicate that [miR-346] *controls* synthesis by regulating TTP expression . Regulation MYLIP TNF 23275201 2758077 These results suggest that the expression of [hsa-miR-26b] is *affected* by , leptin and resistin and that hsa-miR-26b may be an important mediator in regulating the obesity related insulin sensitivity and inflammatory responses . Regulation MYLIP TNF 23606743 2800185 Moreover , our results demonstrate that [miR-128a] expression levels are negatively *controlled* by . Regulation MYLIP TNF 24065523 2857719 FFAs , resistin , and leptin downregulated miR-143 expression in human adipocytes , whereas and IL-6 had little *effect* on [miR-143] expression . Regulation MYLIP TP63 22949650 2672656 Here , we show that ( both TAp63 and ?Np63 isoforms ) *regulates* expression of [miR-205] in prostate cancer ( PCa ) cells , and miR-205 is essential for the inhibitory effects of p63 on markers of epithelial-mesenchymal transition (EMT) , such as ZEB1 and vimentin . Regulation MYLIP WNT7A 23862015 2817428 Surprisingly , we also identify specific *regulation* of [hsa-miR29b] by but not by Wnt3 , a ligand for ß-catenin dependent signaling . Regulation MYLK EPHB2 24116218 2853120 Collectively , our results are the first to delineate a *role* for calcium and in the activation of [MLCK] and thus MyoIIA during insulin stimulated glucose uptake in 3T3-L1 adipocytes . Regulation MYLK TNF 15701621 1372572 In conclusion , our results indicate for the first time that 1 ) the increase in Caco-2 TJ permeability was mediated by an increase in MLCK protein expression , 2 ) the increase in [MLCK] protein expression was *regulated* by an increase in MLCK mRNA transcription , and 3 ) the increase in Caco-2 TJ permeability required MLCK protein expression dependent increase in MLCK activity . Regulation MYLK TNF 16835238 1606494 Analysis of differentiating epithelia showed that only well differentiated enterocytes activated the 4-kb long [MLCK] promoter in *response* to , and consensus promoter reporters demonstrated that TNF induced NFkappaB activation decreased during differentiation while TNF induced AP-1 activation increased . Regulation MYO10 F2R 22326025 2565503 We further demonstrate that the cell polarity protein ( MARK ) , a serine-threonine kinase , *regulates* the localization and activation of [Myo-II] in border cells . Regulation MYO10 MYH16 9398679 469145 This suggests that [myosin] localization in dividing cells is *regulated* by phosphorylation . Regulation MYO10 MYH3 9398679 469152 This suggests that [myosin] localization in dividing cells is *regulated* by phosphorylation . Regulation MYO16 F2R 22326025 2565502 We further demonstrate that the cell polarity protein ( MARK ) , a serine-threonine kinase , *regulates* the localization and activation of [Myo-II] in border cells . Regulation MYO16 MYH16 9398679 469131 This suggests that [myosin] localization in dividing cells is *regulated* by phosphorylation . Regulation MYO16 MYH3 9398679 469138 This suggests that [myosin] localization in dividing cells is *regulated* by phosphorylation . Regulation MYO19 F2R 22326025 2565501 We further demonstrate that the cell polarity protein ( MARK ) , a serine-threonine kinase , *regulates* the localization and activation of [Myo-II] in border cells . Regulation MYO19 MYH16 9398679 469117 This suggests that [myosin] localization in dividing cells is *regulated* by phosphorylation . Regulation MYO19 MYH3 9398679 469124 This suggests that [myosin] localization in dividing cells is *regulated* by phosphorylation . Regulation MYO1F MYH16 16443752 1516990 [Myosin-IE] motor activity is *regulated* by phosphorylation , which increases the coupling efficiency between the actin and nucleotide binding sites tenfold and the motile activity more than fivefold . Regulation MYO1F MYH3 16443752 1516997 [Myosin-IE] motor activity is *regulated* by phosphorylation , which increases the coupling efficiency between the actin and nucleotide binding sites tenfold and the motile activity more than fivefold . Regulation MYO6 F2R 22326025 2565504 We further demonstrate that the cell polarity protein ( MARK ) , a serine-threonine kinase , *regulates* the localization and activation of [Myo-II] in border cells . Regulation MYO6 MYH16 9398679 469159 This suggests that [myosin] localization in dividing cells is *regulated* by phosphorylation . Regulation MYO6 MYH3 9398679 469166 This suggests that [myosin] localization in dividing cells is *regulated* by phosphorylation . Regulation MYOD1 FOXO1 23645752 2779587 Pulse-chase and cycloheximide experiments suggest that GREM1 , DAPK1 , and [MYOD1] are directly *regulated* by . Regulation NA EPHB2 15965078 1423460 We investigated whether H2O2 , superoxide , and participate in nerve growth factor (NGF) induced signaling cascades and whether antioxidant [N-acetylcysteine (NAC)] *regulates* these NGF induced responses . Regulation NAA25 MMP7 18653469 1967105 [p120] and Kaiso *regulate* Helicobacter pylori induced expression of . Regulation NAB1 RAB31 14606102 1161970 To study the *effect* of on [nocturnal acid breakthrough (NAB)] and nocturnal alkaline amplitude ( NAKA ) and to compare it with omeprazole ( OME ) and pantoprazole (PAN) . Regulation NAB2 RAB31 14606102 1161997 To study the *effect* of on [nocturnal acid breakthrough (NAB)] and nocturnal alkaline amplitude ( NAKA ) and to compare it with omeprazole ( OME ) and pantoprazole (PAN) . Regulation NAGLU IL1B 1649133 160896 *Effects* of recombinant human on production of prostaglandin E2 , leukotriene B4 , [NAG] , and superoxide by human synovial cells and chondrocytes . Regulation NAMPT TNF 17447161 1729910 To identify new regulatory mechanisms in fat , the *effect* of ( TNF ) on adiponectin , on its two receptors , and on [visfatin] was investigated by incubating human visceral adipose tissue from patients without diabetes mellitus with TNF for 24 , 48 and 72 hours . Regulation NANOG FOXA1 24803390 2950599 Together , our results suggested a critical *involvement* of in the negative regulation of [Nanog] expression during the differentiation of pluripotent stem cells . Regulation NANOG ZFP57 18687992 1984665 *regulates* [Nanog] through modulation of Oct4 binding . Regulation NANOG ZFP57 18687992 1984719 More interestingly , we further show that *regulates* [Nanog] expression through modulation of Oct4 binding . Regulation NANOS2 ARSA 16105666 1454187 These *effects* of on [NOS2] were paralleled by inhibition in cell growth ( IC50 = 8.5 microM ) . Regulation NANOS2 EPHB2 16283237 1484080 ERK activity is required for NFkappaB mediated transcription of Nos2 in insulin producing INS-1E cells , indicating that *regulates* [Nos2] expression by increasing the transactivating capacity of NFkappaB . Regulation NANOS2 IL1B 11530235 853785 The signaling mechanisms by which *regulates* [NOS-2] and COX-2 genes remain obscure . Regulation NANOS2 IL1B 11530235 853793 However , rotenone inhibited NOS-2 and COX-2 proteins and associated nitric oxide and prostaglandin E ( 2 ) production , respectively , suggesting a posttranscriptional target for mediated *regulation* of [NOS-2] and COX-2 gene expression . Regulation NANOS2 IL1B 11751200 898201 As opposed to the attenuating effect that hypoxia had on *dependent* induction of [NOS 2] gene expression , the concomitant treatment with IL-1beta+TNF-alpha and hypoxia synergistically increased NOS 2 promoter activity 17.6-fold . Regulation NANOS2 KRT38 15353992 1293008 [NOS II] was highly upregulated in *response* to throughout the duration of the study . Regulation NANOS2 TNF 11399519 824237 Together , our results show that binding of IRF-1 and NF-kappa B to their respective sites in the distal domain of the NOS2 promoter , creates a potent trans activating complex with the ability to induce [NOS2] transcription synergistically in *response* to simultaneous and IFN-gamma treatment . Regulation NANOS2 TNF 11751200 898200 As opposed to the attenuating effect that hypoxia had on *dependent* induction of [NOS 2] gene expression , the concomitant treatment with IL-1beta+TNF-alpha and hypoxia synergistically increased NOS 2 promoter activity 17.6-fold . Regulation NANOS2 TNF 7544539 318313 To determine whether these cells can also produce NO , we studied the *effects* of and interferon-gamma (IFN-gamma) on NO production , NOS II mRNA , and [NOS II] protein expression . Regulation NANOS3 GPR115 16997880 1628783 These data support our hypothesis that increased Po ( 2 ) at birth promotes dissociation of caveolin-1 and NOS-3 , with an increase in their activities , and that PKC and an oxygen-sensitive cell surface *regulate* caveolin-1 and [NOS-3] interactions in fetal and neonatal lung MVECs . Regulation NANOS3 GPR132 16997880 1628772 These data support our hypothesis that increased Po ( 2 ) at birth promotes dissociation of caveolin-1 and NOS-3 , with an increase in their activities , and that PKC and an oxygen-sensitive cell surface *regulate* caveolin-1 and [NOS-3] interactions in fetal and neonatal lung MVECs . Regulation NANOS3 GPR87 16997880 1628852 These data support our hypothesis that increased Po ( 2 ) at birth promotes dissociation of caveolin-1 and NOS-3 , with an increase in their activities , and that PKC and an oxygen-sensitive cell surface *regulate* caveolin-1 and [NOS-3] interactions in fetal and neonatal lung MVECs . Regulation NANOS3 TNF 22566503 2596431 However , the *effects* of on THAL [NOS3] and the signaling cascade are unknown . Regulation NANOS3 TNF 9537427 497545 These results suggest that may *regulate* [NOS3] expression in the portal hypertensive stomach and that anti-TNF-alpha treatment may ameliorate the pathophysiological abnormalities of portal hypertensive gastric mucosa . Regulation NAP1L2 CDKN1C 21333655 2404019 [NAP1L2] *controls* the expression of its target genes , such as the cell cycle regulator , at least in part via an effect on histone acetylation . Regulation NAV1 TNF 20638792 2329282 These data suggest that increased may be *responsible* for up-regulation of [Nav1] .3 and Nav1 .8 in uninjured DRG neurons following nerve injury . Regulation NAV1 TNF 24445633 2901575 The *effects* of on the expression of [NaV1] .7 were examined with reverse transcription-polymerase chain reaction and Western blot analysis . Regulation NBL1 IL1B 7517798 261748 We studied the *effect* of human recombinant on synthesis of [NO2-/NO3-] ( NOx ) and the expression of NOS mRNA and protein in cultured neonatal rat cardiocytes . Regulation NCAM1 EPHB2 12694399 1080742 These results indicate that D2R induced NF-kappaB activation through may be *involved* in activation of the [NCAM] promoter , and additionally that other protein kinases such as CaM KII and p38 MAPK also regulate NCAM expression . Regulation NCAM1 EPHB2 18656513 1972817 Relative *role* of upstream regulators of Akt , and CREB in [NCAM-] and FGF2 mediated signalling . Regulation NCAM2 EPHB2 12694399 1080745 These results indicate that D2R induced NF-kappaB activation through may be *involved* in activation of the [NCAM] promoter , and additionally that other protein kinases such as CaM KII and p38 MAPK also regulate NCAM expression . Regulation NCAM2 EPHB2 18656513 1972821 Relative *role* of upstream regulators of Akt , and CREB in [NCAM-] and FGF2 mediated signalling . Regulation NCF1 TNF 12807699 1185281 p22phox antisense oligonucleotide prevented the induced *effect* on p22phox , [p47phox] , O2-* , and permeability . Regulation NCF1 TNF 23639811 2805080 Cumulatively , these results demonstrate that NOX2 and its activator subunits ( [p47phox] and Rac ) *control* the secretion of by the liver following I/R. Interestingly , in the absence of Kupffer cells and NOX2 , NOX1 played a dominant role in TNF-a production following hepatic I/R . Regulation NCF2 TNF 17462995 1750043 Knockdown of PLAGL2 protein inhibited up-regulation of NCF2 transcript , [p67(phox)] protein expression , and subsequent superoxide production in *response* to . Regulation NCK1 NGFR 1333046 204324 The phosphorylation of [Nck] is also enhanced in *response* to stimulation of the in PC12 cells , the T-cell receptor complex in Jurkat cells , the membrane immunoglobulin M in Daudi cells , and the low-affinity immunoglobulin G receptor ( Fc gamma RII ) in U937 cells . Regulation NCOA3 EPHB2 12824291 1113654 These results indicate that *dependent* [R-Smad] linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells . Regulation NCOA3 TNF 24918060 2941882 The levels of [RAC3] expression are up *regulated* by in the inflammatory response . Regulation NDE1 STK39 18083840 1837572 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation NDEL1 STK39 18083840 1837587 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation NEDD1 AXIN2 19390532 2089384 These results suggest that , but not Axin2 , is *involved* in microtubule nucleation by forming a complex with [gamma-tubulin] at the centrosome . Regulation NEDD9 ACTR1A 16184168 1462160 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 AKAP9 16184168 1462195 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 ALMS1 16184168 1462196 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 B2M 18224667 1876789 [Cas-L] activity was *independent* of level but not of immunoglobulin variable heavy chain gene ( IgVH ) mutation status . Regulation NEDD9 CDC73 7947998 277246 In the present study , we developed a competitive PCR method to quantitate the transcripts of NF-kappa B p50/p105 gene , and investigated the *effects* of and TNF on [p50/p105] gene expression in the small intestine of C3H/HeN mice - p105 is the precursor of the p50 subunit of NF-kB . Regulation NEDD9 CDK1 16184168 1462163 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 CDK5RAP2 16184168 1462168 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 CENPJ 16184168 1462164 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 CEP135 16184168 1462186 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 CEP152 16184168 1462190 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 CEP164 16184168 1462188 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 CEP192 16184168 1462173 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 CEP250 16184168 1462166 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 CEP290 16184168 1462184 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 CEP57 16184168 1462194 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 CEP63 16184168 1462179 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 CEP70 16184168 1462193 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 CEP72 16184168 1462175 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 CEP76 16184168 1462177 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 CEP78 16184168 1462178 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 CETN2 16184168 1462167 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 CKAP5 16184168 1462183 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 CLASP1 16184168 1462162 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 CRKL 9498705 477259 Therefore , is *involved* in the formation of a [HEF1-CrkL-C3G] ternary complex in B-cells , suggesting that it is likely to play an important role , allowing the propagation of the stimulation initiated by both BCR and beta1 integrin ligation . Regulation NEDD9 CRTC1 23074285 2706739 Mechanistically , LKB1 negatively *regulated* [NEDD9] transcription by promoting cytosolic translocation of from the nucleus . Regulation NEDD9 CSNK1D 16184168 1462171 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 CSNK1E 16184168 1462172 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 CTR9 7947998 277247 In the present study , we developed a competitive PCR method to quantitate the transcripts of NF-kappa B p50/p105 gene , and investigated the *effects* of and TNF on [p50/p105] gene expression in the small intestine of C3H/HeN mice - p105 is the precursor of the p50 subunit of NF-kB . Regulation NEDD9 DCTN1 16184168 1462180 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 DCTN2 16184168 1462181 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 DCTN3 16184168 1462182 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 DYNC1H1 16184168 1462191 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 DYNC1I2 16184168 1462192 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 DYNLL1 16184168 1462158 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 FGFR1OP 16184168 1462161 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 FYN 10447714 576820 and Lck tyrosine kinases *regulate* tyrosine phosphorylation of [p105CasL] , a member of the p130Cas docking protein family , in T-cell receptor mediated signalling . Regulation NEDD9 GSK3B 12871932 1142274 *regulates* NF-kappa [B1/p105] stability . Regulation NEDD9 HAUS2 16184168 1462174 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 HSP90AA1 16184168 1462197 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 ITCH 15051726 1265232 forms a complex with both Smad3 and HEF1 through its WW domains in a TGF-beta independent manner and *regulates* [HEF1] ubiquitination and degradation , which can be enhanced by TGF-beta stimulation . Regulation NEDD9 LEO1 7947998 277250 In the present study , we developed a competitive PCR method to quantitate the transcripts of NF-kappa B p50/p105 gene , and investigated the *effects* of and TNF on [p50/p105] gene expression in the small intestine of C3H/HeN mice - p105 is the precursor of the p50 subunit of NF-kB . Regulation NEDD9 MAPK1 10954702 744367 Furthermore , inhibition of Erk1 and phosphorylation had no *effect* on the calcitonin induced phosphorylation of paxillin and [HEF1] . Regulation NEDD9 MAPK3 10954702 744368 Furthermore , inhibition of and Erk2 phosphorylation had no *effect* on the calcitonin induced phosphorylation of paxillin and [HEF1] . Regulation NEDD9 MAPRE1 16184168 1462198 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 NDE1 16184168 1462165 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 NEDD1 16184168 1462199 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 NEK2 16184168 1462200 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 NINL 16184168 1462187 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 ODF2 16184168 1462201 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 OFD1 16184168 1462176 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 PAF1 7947998 277248 In the present study , we developed a competitive PCR method to quantitate the transcripts of NF-kappa B p50/p105 gene , and investigated the *effects* of and TNF on [p50/p105] gene expression in the small intestine of C3H/HeN mice - p105 is the precursor of the p50 subunit of NF-kB . Regulation NEDD9 PAFAH1B1 16184168 1462202 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 PCM1 16184168 1462203 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 PCNT 16184168 1462159 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 PLCH1 16184168 1462189 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 PLK1 16184168 1462204 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 PLK4 16184168 1462153 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 PPP2R1A 16184168 1462205 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 PRKACA 16184168 1462206 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 PRKAR2B 16184168 1462207 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 SDCCAG8 16184168 1462151 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 SFI1 16184168 1462185 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 SMAD3 15051726 1265227 The detailed molecular mechanisms of [HEF1] degradation *regulated* by were poorly understood . Regulation NEDD9 SP1 9151857 430865 Because both promoters were transactivated by Sp1 , we reasoned that the upregulation of *played* a role in p65 and [p105/p50] promoter activity during infection . Regulation NEDD9 SP1 9151857 430871 To address the specific *role* of in p65 and [p105/p50] promoter transactivation by HCMV , we mutated both promoters . Regulation NEDD9 SRC 10954702 744357 Overexpression of lacking the SH3 domain did not *affect* the calcitonin induced phosphorylation of paxillin and [HEF1] . Regulation NEDD9 SSNA1 16184168 1462152 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 STK11 23074285 2706738 Mechanistically , negatively *regulated* [NEDD9] transcription by promoting cytosolic translocation of CRTC1 from the nucleus . Regulation NEDD9 TGFB1 12189134 992640 had no *effect* on the stability of either [HEF1] protein or mRNA . Regulation NEDD9 TGFB1 12189134 992651 These findings suggest that *regulates* [HEF1] gene expression and that HEF1 phosphorylation is dependent on cell adhesion and Src kinase activity . Regulation NEDD9 TNF 11976329 954028 Phosphorylation of serine 927 within the p105 PEST region by the IkappaB kinase (IKK) complex is required to promote [p105] proteolysis in *response* to stimulation . Regulation NEDD9 TNF 7947998 277245 In the present study , we developed a competitive PCR method to quantitate the transcripts of NF-kappa B p50/p105 gene , and investigated the *effects* of PAF and on [p50/p105] gene expression in the small intestine of C3H/HeN mice - p105 is the precursor of the p50 subunit of NF-kB . Regulation NEDD9 TUBA1A 16184168 1462169 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 TUBA4A 16184168 1462154 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 TUBB 16184168 1462170 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 TUBG1 16184168 1462155 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 WDR61 7947998 277249 In the present study , we developed a competitive PCR method to quantitate the transcripts of NF-kappa B p50/p105 gene , and investigated the *effects* of and TNF on [p50/p105] gene expression in the small intestine of C3H/HeN mice - p105 is the precursor of the p50 subunit of NF-kB . Regulation NEDD9 YWHAE 16184168 1462156 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEDD9 YWHAG 16184168 1462157 The focal adhesion scaffolding protein [HEF1] *regulates* activation of the Aurora-A and Nek2 kinases at the . Regulation NEFH EPHB2 16447269 1527959 We have employed a differentiated mouse neuroblastoma N2a cell model to investigate the *involvement* of JNK and in MPTP mediated toxicity and their role in [neurofilament heavy chain (NF-H)] phosphorylation . Regulation NEFL NR2F1 7674376 326013 In contrast , expression of the [neurofilament light subunit (NF-L)] gene is not *affected* by overexpression during neuronal differentiation . Regulation NELFCD ARSA 20337611 2299869 To evaluate the therapeutic or adverse *effects* of on the expression of [Th1-type] and Th17-type inflammation induced by airway exposure to LPS containing allergens . Regulation NELFCD CCND1 9269780 450127 Susceptible hosts developed a T helper 2 ( Th2 ) -dominant response , whereas resistant hosts developed a [Th1-dominant] *response* to . Regulation NELFCD EPHB2 11971021 933502 In contrast , *plays* a central negative regulatory role in the CpG DNA mediated [Th1] type response by promoting production of the Th2 type cytokine , IL-10 . Regulation NELFCD FAS 9341746 458753 CD40 ligand (CD40L) has been shown to increase surface Fas expression and induce B cell sensitivity to *dependent* CD4+ [Th1 cell mediated cytotoxicity (Th1-CMC)] . Regulation NELFCD IL1B 20685294 2311930 Consistent with an increasing [Th1] *response* to H. pylori , IgG2a ( p < 0.01 ) , ( p = 0.04 ) and CXCL1 ( p = 0.006 ) responses significantly increased and IL-4 ( p = 0.05 ) and IL-10 ( p = 0.04 ) were decreased in coinfected gerbils at 42 weeks . Regulation NELFCD JAG1 10820273 694419 CD40L expression promotes [Th1] cytokine *responses* to protein and is responsible for Ig isotype switching in B cells . Regulation NELFCD JAG1 11067933 747513 LTK63 , an LT mutant that is completely devoid of enzyme activity , enhanced [Th1] *responses* to coinjected at low adjuvant dose . Regulation NELFCD JAG1 11751945 898608 The arthritis promoting effect of the Mtb DNA or of the ISS oligodeoxynucleotides correlated with an increased [Th1] *response* to Mtb , as measured by the production of IFN-gamma and increased production of the osteoclast differentiation factor , receptor activator of NF-kappaB ligand ( RANKL ) . Regulation NELFCD JAG1 11777990 899964 We previously reported that Mycobacterium bovis bacillus Calmette-Guérin ( BCG ) vaccination induces a potent [Th1] *response* to mycobacterial in newborns . Regulation NELFCD JAG1 11777990 899965 Although BCG induced a potent [Th1-type] *response* to mycobacterial , it promoted the production of both Th1- and Th2-type cytokines in response to unrelated vaccines . Regulation NELFCD JAG1 11937541 928100 A LAG-3Ig fusion protein has been used in mice as an adjuvant protein to induce antitumor responses and specific CD8 and CD4 [Th1] *responses* to nominal . Regulation NELFCD JAG1 18322186 1881158 TLR ligands are potent adjuvants and promote [Th1] *responses* to coadministered by inducing innate IL-12 production . Regulation NELFCD JAG1 21278348 2392865 Thus , prenatal exposure to malaria blood-stage Ags induces T ( regs ) that primarily suppress [Th1-type] recall *responses* to P. falciparum blood-stage . Regulation NELFCD JAG1 21317393 2398833 Coinfected animals experienced increased [Th1] cytokine *responses* to M. tuberculosis above the latent-response baseline 3-5 wk post-SIV infection that corresponded with peak plasma viremia . Regulation NELFCD JAG1 9862708 556068 Overall , this study demonstrates for the first time that relative resistance to African trypanosomes is associated with a strong [Th1] cell *response* to parasite , that IFN-gamma , but not IL-4 , is linked to host resistance , and that susceptible animals do not make compensatory Th2 cell responses in the absence of Th1 cell cytokine responses . Regulation NELFCD SELL 20182448 2248646 We attempted to determine the *role* of and ICAM-1 in [Th1-] and Th2-type CHS induced by DNFB or FITC in mice lacking either L-selectin , ICAM-1 , or both . Regulation NELFCD SPHK1 17980413 1850358 These alterations in T ( H ) 2-associated and T(H)1 associated recall responses were associated with increased expression of Gata-3 and , a [T(H)1] negative *regulator* , independent of T-bet expression . Regulation NELFCD STAT4 15271915 1276588 A *dependent* [Th1] response is required for resistance to the helminth parasite Taenia crassiceps . Regulation NELFCD STAT4 15271915 1276590 To determine the role of dependent [Th1] *responses* in the regulation of immunity to the helminth parasite Taenia crassiceps , we monitored infections with this parasite in resistant mice lacking the STAT4 gene . Regulation NELFCD STAT4 23772023 2807568 Opposing *roles* of and Dnmt3a in [Th1] gene regulation . Regulation NELFCD TCN1 10910289 713971 Here , we compared the capacity of in vitro generated normal liver immature DC and FL-treated donor liver DC to induce alloimmune CD4+ [T helper (Th) 1/Th2] and CD8+ *responses* , in vitro and in vivo . Regulation NELFCD TLR7 17576775 1767960 However , dependent [Th1] *responses* occur in the absence of IL-12 . Regulation NELFCD TLR7 18377768 1888569 stimulation *controls* [T helper (Th) 1] , Th2 , and Th17 cell differentiation , cytokine production in mast cells , and activation of eosinophils via direct and indirect pathways . Regulation NELFCD TLR7 20309865 2281707 Expression of Toll-like receptor 3 and in muscle is characteristic of inflammatory myopathy and is differentially *regulated* by [Th1] and Th17 cytokines . Regulation NELFCD TLR7 21555403 2445050 To the best of our knowledge , this study provides the first evidence that TREM-1 functions as an inflammatory amplifier in P. aeruginosa keratitis by modulating signaling and [Th1/Th2] *responses* . Regulation NELFCD TNF 11454638 837701 To evaluate the *effect* of on the [Th1] and Th2 cytokines in patients with spondyloarthropathy (SpA) . Regulation NELFCD TNF 12122596 965244 [TH1/TH2] serum cytokine profiles and soluble *response* in patients with chronic hepatitis C during recombinant human interleukin-12 ( rHuIL-12 ) treatment . Regulation NELFCD TNF 17944748 1814247 The *role* of in Trichuris muris infection II : global enhancement of ongoing [Th1] or Th2 responses . Regulation NELFCD TNF 18936235 1982143 These findings indicate that at least one of the ways in which *regulates* [Th1/Th17] responses in arthritis is by down regulating the expression of p40 . Regulation NELFCD TNF 20559676 2302540 In conclusion , plasma levels of CXCL9 , sTNFR1 , and sTNFR2 were independently associated with liver histological changes , suggesting a role of activation and [Th1-type] cell mediated immune *response* in the pathogenesis of HCV infection . Regulation NELFCD TNF 21091114 2350021 is a potent inducer of the inflammatory response , a key regulator of innate immunity and *plays* an important role in the regulation of [Th1] immune responses against intracellular bacteria and certain viral infections . Regulation NELFCD TNF 22834815 2706105 Artesunate suppresses expression in vitro and in vivo as well as [T-helper (Th)1/Th17] *responses* in TNBS colitis model . Regulation NELFCD TNF 9550432 477818 To assess the role of TNF-alpha in mucosal cytokine regulation , the *effects* of on lamina propria mononuclear cell ( LPMC ) [Th1] production were determined . Regulation NEO1 DAPK1 18583991 1959364 Thus , [RGM/neogenin] *regulates* cell fate by controlling the activity . Regulation NES ANXA2 17457518 1778063 However , the *involvement* of in DNA replication as a part of primer recognition protein complex and the presence of [nuclear export signal (NES)] suggest that annexin A2 is also functional in the nucleus , and its localization in the nucleus is under regulation by interaction with other nuclear factors through its N-terminus . Regulation NES CDC25B 15003534 1217247 The nuclear exclusion of is *controlled* by the binding of 14-3-3 to the [nuclear export signal (NES)] of CDC25B , which was reported to be amino acids H28 to L40 in the N-terminal region of CDC25B . Regulation NES CLTA 22400223 2521128 The uptake mechanism results demonstrated that the internalization of [CTAB-NES] and NES *involved* and caveolae mediated endocytosis while macropinocytosis only influenced the uptake of CTAB-NES in MCF-7 cells for CTAB could mediate adsorptive pinocytosis . Regulation NES CLTC 22400223 2521129 The uptake mechanism results demonstrated that the internalization of CTAB-NES and [NES] *involved* and caveolae mediated endocytosis while macropinocytosis only influenced the uptake of CTAB-NES in MCF-7 cells for CTAB could mediate adsorptive pinocytosis . Regulation NES CRK 24462842 2918285 Inhibition of the PLC? , PI3K , ERK , , and JNK pathways did not *affect* [Nestin] expression in reactive astrocytes . Regulation NES DES 10438587 634907 [Nestin] expression at these specialized sites , as well as during myogenesis and myofibrillogenesis , is *independent* of the presence of . Regulation NES EGF 19673937 2119678 The *effect* of on post-stroke cerebral expression of [nestin] , a marker of neural progenitor cells , has not been examined in hypertensive rats . Regulation NES EGF 24462842 2918284 Furthermore , as shown by immunoblot analyses , *regulated* [Nestin] expression through EGFR activation . Regulation NES EGFR 19245830 2050741 In this study , we showed that [nestin] expression is *regulated* by the thrombin mediated transactivation in serum deprived primary cultures of rat vascular smooth muscle cells ( VSMCs ) . Regulation NES FGF2 16787599 1577556 This study investigated the *effect* of exogenous on [nestin] expression in neonatal rats following hypoxia-ischemia ( HI ) and to explore the possible mechanism . Regulation NES GCG 17366624 1727469 Furthermore , our results suggest that [nestin] expression is *regulated* by signaling . Regulation NES IL1B 19940926 2167652 Importantly , [Nestin-Cre] and GFAP-Cre rank ( floxed ) deleter mice are resistant to lipopolysaccharide induced fever as well as fever in *response* to the key inflammatory cytokines and TNFalpha . Regulation NES LCN2 21346193 2420581 [Nestin] *regulated* the cleavage of the Cdk5 activator protein p35 to its degradation-resistant form , . Regulation NES MSN 22889732 2647133 Strikingly , Cln2 export depends on a *dependent* [NES] between amino acids 225 and 299 . Regulation NES MYCN 15117961 1258521 Neuroblastic cell variants with high levels of N-Myc protein have significantly higher nestin protein levels than non amplified cell lines , suggesting that the transcription factor may *regulate* [nestin] expression . Regulation NES NOTCH1 15246688 1271062 We also show that [nestin] loss is *regulated* by , and mediated by cell contact . Regulation NES NOTCH2 15246688 1271063 We also show that [nestin] loss is *regulated* by , and mediated by cell contact . Regulation NES NOTCH3 15246688 1271064 We also show that [nestin] loss is *regulated* by , and mediated by cell contact . Regulation NES NOTCH4 15246688 1271065 We also show that [nestin] loss is *regulated* by , and mediated by cell contact . Regulation NES PIK3CA 24462842 2918286 Inhibition of the PLC? , , ERK , p38 , and JNK pathways did not *affect* [Nestin] expression in reactive astrocytes . Regulation NES PIK3R1 24462842 2918287 Inhibition of the PLC? , , ERK , p38 , and JNK pathways did not *affect* [Nestin] expression in reactive astrocytes . Regulation NES RAN 10502415 648751 This protein , which is related to the karyopherin beta family , interacts directly with [NES] in a *dependent* manner . Regulation NES SMAD4 23552743 2810089 The TGF-ß1/Smad4 pathway induced [nestin] protein expression in PDAC cells in a *dependent* manner . Regulation NES SOX11 20951776 2369294 In the injured spinal cord , expression of the neural stem cell associated gene [Nestin] , and the proneural gene Ascl1a ( Mash1a ) , which are involved in the self-renewal and cell fate specification of endogenous neural stem cells , respectively , is *regulated* by . Regulation NES TGFB1 18005096 1971422 Alpha-smooth muscle actin ( alpha-SMA ) and [nestin] expression in reactive astrocytes in multiple sclerosis lesions : potential regulatory *role* of ( TGF-beta1 ) . Regulation NES TP53 18343205 1898327 The comet-NE assay , a conventional alkaline comet assay which includes a nuclear digestion step , was used to examine the *effects* of on the excision activity of [nuclear extracts (NEs)] . Regulation NES USO1 21060813 2344796 In addition to the revised map of NLS , our results suggest that HBc could shuttle rapidly between nucleus and cytoplasm via a novel *dependent* [NES] . Regulation NES WT1 16614054 1589531 Intermediate filament protein [nestin] is expressed in developing kidney and heart and might be *regulated* by the Wilms' tumor suppressor . Regulation NES XPO1 10581242 570227 This shuttling requires a previously unidentified *dependent* [nuclear export signal (NES)] located within the N-terminal domain of IkappaBalpha at amino acids 45-55 . Regulation NES XPO1 12438613 1016830 Thus , this region is required for efficient ICP27 export but does not function as a *dependent* [NES] . Regulation NES XPO1 12821673 1134483 The Smad1 NES2 mutant but not the Smad1 NES1 mutant is mostly resistant to this cytoplasmic targeting , indicating that [NES2] , not NES1 , is the major *target* for in Smad1 . Regulation NES XPO1 14617633 1200698 We identified a novel *dependent* [nuclear export signal (NES)] comprising 13 amino acids ( KKVVKQASEGPLK ) in the C-terminal domain of GAPDH , truncation or mutation of which abrogated CRM1 binding and caused nuclear accumulation of GAPDH . Regulation NES XPO1 14638854 1171554 Nuclear import of an nuclear localization signal enhanced green fluorescent protein ( NLS-EGFP ) reporter is not affected in DNup88 ( members only ; mbo ) mutants , whereas the level of *dependent* EGFP-nuclear export signal ( [EGFP-NES] ) export is increased . Regulation NES XPO1 14647430 1218709 We identified a functional *dependent* [nuclear export sequence (NES)] near the N-terminal RING domain of BARD1 . Regulation NES XPO1 15113915 1241383 Analysis of the Nipah virus V protein has revealed a region between amino acids 174 and 192 that functions as a *dependent* [nuclear export signal (NES)] . Regulation NES XPO1 15265700 1275440 We have identified a new *dependent* leucine-rich [nuclear export signal (NES)] in the linker region between cIAP1 BIR2 and BIR3 repeats . Regulation NES XPO1 16093348 1460721 We also identify a *dependent* [nuclear export signal (NES)] adjacent to the Mcm3 NLS . Regulation NES XPO1 16483627 1567646 Mutations on the leucine-rich region of BRO proteins resulted in nuclear accumulation of transiently expressed proteins , suggesting that this region functions as a *dependent* [nuclear export signal (NES)] . Regulation NES XPO1 16738331 1566337 Here we identify a bipartite nuclear localization signal ( NLS ) and a *dependent* [nuclear export signal (NES)] in the SUMO protease SENP2 . Regulation NES XPO1 16782704 1599373 However , under isotonic conditions , nuclear export of OREBP/TonEBP is mediated by a *dependent* , leucine-rich canonical [nuclear export sequence (NES)] located in the N terminus . Regulation NES XPO1 16785531 1577109 A *dependent* [nuclear export signal (NES)] at the AID C terminus is necessary for CSR , and has been suggested to associate with CSR-specific cofactors . Regulation NES XPO1 16888326 1632453 Here we show that Ltv1 shuttles between nucleus and cytoplasm in a *dependent* manner and that it contains a functional [NES] that is sufficient to direct the export of an NLS containing reporter . Regulation NES XPO1 16984408 1633665 We show that the dynamic intracellular localization of survivin ( 140 ) is mediated by a *dependent* [nuclear export signal (NES)] present also in survivin ( 121 ) , but absent in survivin ( 40 ) . Regulation NES XPO1 17065226 1649633 We first reported a *dependent* [nuclear export signal (NES)] in E1A that is conserved in the group C adenoviruses . Regulation NES XPO1 17099069 1676209 We identified an evolutionary conserved *dependent* [nuclear export signal (NES)] in survivin . Regulation NES XPO1 17099693 1650812 Here , we show that the nuclear export receptor is crucially *involved* in tethering the CPC to the centromere by interacting with a leucine-rich [nuclear export signal (NES)] , evolutionarily conserved in all mammalian Survivin proteins . Regulation NES XPO1 17185387 1688395 Additionally , we identify a cryptic *dependent* [nuclear export signal (NES)] within ZIC3 , and identify a mutation within this region in a patient with heterotaxy . Regulation NES XPO1 17303464 1705074 The Rev ( 1.4 ) -EGFP nuclear export assay showed that this putative NES has a *dependent* [NES] activity . Regulation NES XPO1 17582222 1764175 We here show that the intracellular localization of these splice variants depends on a *dependent* [nuclear export signal (NES)] present in survivin , surviving ( -2B ) and survivin ( -3B ) , but absent in survivin ( -deltaEx3 ) and survivin ( -2alpha ) . Regulation NES XPO1 19144820 2037888 Surprisingly , fusions of Mex67 , the tRNA exportin Los1 , Mtr2 , Cse1 , or Msn5 to Nmd3 , lacking its *dependent* [nuclear export signal (NES)] , all functioned in export . Regulation NES XPO1 20685962 2322832 We identify highly conserved carboxy-terminal hydrophobic amino acids that function as a leptomycin B-sensitive , *dependent* [nuclear export sequence (NES)] in the AMPK catalytic subunit ( AMPKa ) . Regulation NES XPO1 21979574 2493022 Furthermore , the UL4 protein was demonstrated to be exported to the cytoplasm through the [NES] in a *dependent* manner involving RanGTP hydrolysis . Regulation NES XPO1 22623727 2686821 Here , we characterize the active nuclear export of cofilin through a leptomycin-B-sensitive , *dependent* , [nuclear export signal (NES)] . Regulation NEU1 TLR7 20864924 2326122 It suggests that ligand induced activation is tightly *controlled* by [Neu1] sialidase activation . Regulation NEU2 TLR7 20864924 2326132 It suggests that ligand induced activation is tightly *controlled* by Neu1 [sialidase] activation . Regulation NEU3 TLR7 20864924 2326142 It suggests that ligand induced activation is tightly *controlled* by Neu1 [sialidase] activation . Regulation NEU4 TLR7 20864924 2326112 It suggests that ligand induced activation is tightly *controlled* by Neu1 [sialidase] activation . Regulation NEUROD1 CABP4 11563845 863000 An MN9D dopaminergic neuronal cell line overexpressing calbindin-D28K ( MN9D/Calbindin ) was established in order to investigate directly the potential *role* of in [neuronal differentiation] . Regulation NEUROD1 EPHB2 15970380 1434677 transiently down-regulated SVZ cell mRNA of Notch1 and Zic1 , genes that *regulate* neurogenesis and [neuronal differentiation] . Regulation NEUROD1 EPHB2 17976838 1831226 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Regulation NEUROD1 IFI27 10837916 699519 Expression and *role* of ( kip1 ) in [neuronal differentiation] of embryonal carcinoma cells . Regulation NEUROD1 IFI27 12761887 1091765 Using N2A cells as a model , we investigated the detailed molecular aspects on the *involvement* of in dibutyryl cAMP induced [neuronal differentiation] . Regulation NEUROD1 IFI27 16023837 1441620 Our results suggest that *plays* a role in terminal [neuronal differentiation] of human EC cells , but not in their initial commitment to differentiation , and that other factors , possibly Cyclin D2 , specifically limit its ability to promote neural differentiation . Regulation NEUROD1 MAP2K6 17976838 1831232 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Regulation NEUROD1 NR2F1 11117523 759323 We have studied the functional *involvement* of in retinoic acid (RA) induced [neuronal differentiation] of P19 embryonal carcinoma cells through two complementary approaches : 1 ) deregulated expression of COUP-TFI , and 2 ) inactivation of endogenous COUP-TFs by means of a dominant negative COUP-TFI mutant . Regulation NEUROD1 TGM2 11166134 782923 Considering these and other previous findings , this study was carried out to determine whether is *involved* in [neuronal differentiation] of SH-SY5Y cells . Regulation NEUROD1 TLR7 23843519 2816465 These results all suggest that negatively *regulates* [neuronal differentiation] . Regulation NEUROD1 TMOD1 23638401 2779385 did not *affect* [neuronal differentiation] ; Regulation NEUROD1 TMOD1 23638401 2779394 Our data demonstrate that is *involved* in [neuronal differentiation] for proper neurite formation and outgrowth , and that Tmod2 inhibits these processes . Regulation NEUROD2 CABP4 11563845 863005 An MN9D dopaminergic neuronal cell line overexpressing calbindin-D28K ( MN9D/Calbindin ) was established in order to investigate directly the potential *role* of in [neuronal differentiation] . Regulation NEUROD2 EPHB2 15970380 1434678 transiently down-regulated SVZ cell mRNA of Notch1 and Zic1 , genes that *regulate* neurogenesis and [neuronal differentiation] . Regulation NEUROD2 EPHB2 17976838 1831234 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Regulation NEUROD2 IFI27 10837916 699520 Expression and *role* of ( kip1 ) in [neuronal differentiation] of embryonal carcinoma cells . Regulation NEUROD2 IFI27 12761887 1091766 Using N2A cells as a model , we investigated the detailed molecular aspects on the *involvement* of in dibutyryl cAMP induced [neuronal differentiation] . Regulation NEUROD2 IFI27 16023837 1441621 Our results suggest that *plays* a role in terminal [neuronal differentiation] of human EC cells , but not in their initial commitment to differentiation , and that other factors , possibly Cyclin D2 , specifically limit its ability to promote neural differentiation . Regulation NEUROD2 MAP2K6 17976838 1831240 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Regulation NEUROD2 NR2F1 11117523 759324 We have studied the functional *involvement* of in retinoic acid (RA) induced [neuronal differentiation] of P19 embryonal carcinoma cells through two complementary approaches : 1 ) deregulated expression of COUP-TFI , and 2 ) inactivation of endogenous COUP-TFs by means of a dominant negative COUP-TFI mutant . Regulation NEUROD2 TGM2 11166134 782924 Considering these and other previous findings , this study was carried out to determine whether is *involved* in [neuronal differentiation] of SH-SY5Y cells . Regulation NEUROD2 TLR7 23843519 2816466 These results all suggest that negatively *regulates* [neuronal differentiation] . Regulation NEUROD2 TMOD1 23638401 2779386 did not *affect* [neuronal differentiation] ; Regulation NEUROD2 TMOD1 23638401 2779395 Our data demonstrate that is *involved* in [neuronal differentiation] for proper neurite formation and outgrowth , and that Tmod2 inhibits these processes . Regulation NEUROD4 CABP4 11563845 862990 An MN9D dopaminergic neuronal cell line overexpressing calbindin-D28K ( MN9D/Calbindin ) was established in order to investigate directly the potential *role* of in [neuronal differentiation] . Regulation NEUROD4 EPHB2 15970380 1434675 transiently down-regulated SVZ cell mRNA of Notch1 and Zic1 , genes that *regulate* neurogenesis and [neuronal differentiation] . Regulation NEUROD4 EPHB2 17976838 1831210 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Regulation NEUROD4 IFI27 10837916 699517 Expression and *role* of ( kip1 ) in [neuronal differentiation] of embryonal carcinoma cells . Regulation NEUROD4 IFI27 12761887 1091763 Using N2A cells as a model , we investigated the detailed molecular aspects on the *involvement* of in dibutyryl cAMP induced [neuronal differentiation] . Regulation NEUROD4 IFI27 16023837 1441618 Our results suggest that *plays* a role in terminal [neuronal differentiation] of human EC cells , but not in their initial commitment to differentiation , and that other factors , possibly Cyclin D2 , specifically limit its ability to promote neural differentiation . Regulation NEUROD4 MAP2K6 17976838 1831216 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Regulation NEUROD4 NR2F1 11117523 759321 We have studied the functional *involvement* of in retinoic acid (RA) induced [neuronal differentiation] of P19 embryonal carcinoma cells through two complementary approaches : 1 ) deregulated expression of COUP-TFI , and 2 ) inactivation of endogenous COUP-TFs by means of a dominant negative COUP-TFI mutant . Regulation NEUROD4 TGM2 11166134 782921 Considering these and other previous findings , this study was carried out to determine whether is *involved* in [neuronal differentiation] of SH-SY5Y cells . Regulation NEUROD4 TLR7 23843519 2816463 These results all suggest that negatively *regulates* [neuronal differentiation] . Regulation NEUROD4 TMOD1 23638401 2779383 did not *affect* [neuronal differentiation] ; Regulation NEUROD4 TMOD1 23638401 2779392 Our data demonstrate that is *involved* in [neuronal differentiation] for proper neurite formation and outgrowth , and that Tmod2 inhibits these processes . Regulation NEUROD6 CABP4 11563845 862995 An MN9D dopaminergic neuronal cell line overexpressing calbindin-D28K ( MN9D/Calbindin ) was established in order to investigate directly the potential *role* of in [neuronal differentiation] . Regulation NEUROD6 EPHB2 15970380 1434676 transiently down-regulated SVZ cell mRNA of Notch1 and Zic1 , genes that *regulate* neurogenesis and [neuronal differentiation] . Regulation NEUROD6 EPHB2 17976838 1831218 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Regulation NEUROD6 IFI27 10837916 699518 Expression and *role* of ( kip1 ) in [neuronal differentiation] of embryonal carcinoma cells . Regulation NEUROD6 IFI27 12761887 1091764 Using N2A cells as a model , we investigated the detailed molecular aspects on the *involvement* of in dibutyryl cAMP induced [neuronal differentiation] . Regulation NEUROD6 IFI27 16023837 1441619 Our results suggest that *plays* a role in terminal [neuronal differentiation] of human EC cells , but not in their initial commitment to differentiation , and that other factors , possibly Cyclin D2 , specifically limit its ability to promote neural differentiation . Regulation NEUROD6 MAP2K6 17976838 1831224 Rit mutants confirm *role* of signaling in [neuronal differentiation] and reveal novel Par6 interaction . Regulation NEUROD6 NR2F1 11117523 759322 We have studied the functional *involvement* of in retinoic acid (RA) induced [neuronal differentiation] of P19 embryonal carcinoma cells through two complementary approaches : 1 ) deregulated expression of COUP-TFI , and 2 ) inactivation of endogenous COUP-TFs by means of a dominant negative COUP-TFI mutant . Regulation NEUROD6 TGM2 11166134 782922 Considering these and other previous findings , this study was carried out to determine whether is *involved* in [neuronal differentiation] of SH-SY5Y cells . Regulation NEUROD6 TLR7 23843519 2816464 These results all suggest that negatively *regulates* [neuronal differentiation] . Regulation NEUROD6 TMOD1 23638401 2779384 did not *affect* [neuronal differentiation] ; Regulation NEUROD6 TMOD1 23638401 2779393 Our data demonstrate that is *involved* in [neuronal differentiation] for proper neurite formation and outgrowth , and that Tmod2 inhibits these processes . Regulation NF1 EPHB2 24211110 2891784 signaling *regulates* [Nf1] heterozygous neointima formation . Regulation NF1 MAP2K6 24211110 2891792 signaling *regulates* [Nf1] heterozygous neointima formation . Regulation NFASC MYLIP 23971736 2841249 We also identified Lrrc4c and [Nfasc] as miR-592 target genes , and could *affect* the changes of Lrrc4c and Nfasc expression levels , suggesting that these two target genes may be involved in miR-592 regulative function in NPCs differentiation and neuronal maturation . Regulation NFAT5 EPHB2 17371162 1760198 Results of this study show that hypertonic activation of signaling *regulates* transactivation activity of [TonEBP] , modulating its function . Regulation NFE2L2 EPHB2 16482620 1524660 PGG up-regulates HO-1 expression by stimulating [Nrf2] nuclear translocation in an *dependent* manner , and HO-1 expression by PGG may serve as one of the important mechanisms for its hepatoprotective effects . Regulation NFE2L2 EPHB2 23479260 2776614 Hydrogen sulfide preconditions the db/db diabetic mouse heart against ischemia-reperfusion injury by activating [Nrf2] signaling in an *dependent* manner . Regulation NFE2L2 EPHB2 23776571 2802258 Interestingly , MEK inhibitor abrogated its nuclear translocation suggesting *role* of in basal and radiation induced [Nrf-2] activation in tumor cells . Regulation NFE2L2 TNF 21670314 2451219 We also showed that autocrine secretion was *responsible* for this sustained [Nrf2] response and that Nrf2 activation by TNF was mediated by the generation of reactive oxygen species . Regulation NFIX CHI3L1 21953450 2507269 Furthermore , is a migration factor for primary astrocytes , and its expression is *controlled* by both [NFI-X3] and STAT3 , which are known regulators of gliogenesis . Regulation NFKB1 ADRB2 19167076 2043522 *regulate* Toll-like receptor 4-induced late-phase [NF-kappaB] activation . Regulation NFKB1 ALOX5 18498541 1917578 We then investigated whether these drugs affect [NF-kappaB] and AP-1 activities in A549 lung epithelial cells , and whether this potential regulation *involves* H1-receptor and <5-LO> . Regulation NFKB1 ARSA 16116334 1449083 This study investigated the *effect* of on the late phase of ischemic preconditioning ( PC ) against myocardial infarction and on the activation of [NF-kappaB] in the preconditioned myocardium . Regulation NFKB1 ARSA 17644113 1865900 The aim of this study was to investigate the *effect* of DC and on [NF-kappaB] signaling , and determine its role in programmed cell death in a human gastric carcinoma cell line . Regulation NFKB1 ARSA 18174252 1875683 We studied in several human colon ( HT-29 , HCT-15 , LoVo , HCT116 and SW-480 ) , pancreatic ( BxPC-3 , MIA PaCa-2 ) and breast ( MDA-MB-231 and MCF-7 ) cancer cell lines , the *effect* of on [NF-kappaB] activation , determined by electrophoretic mobility shift assays , immunofluorescence and western blot analyses of nuclear proteins . Regulation NFKB1 ARSA 18174252 1875687 The *effect* of on [NF-kappaB] binding to DNA was significantly correlated with its effect on cell growth ( P < 0.05 ) indicating that the growth inhibitory effect of NO-ASA may be mediated by its effect on NF-kappaB . Regulation NFKB1 CAPN8 14686903 1179536 Our data indicate that the Ca2+ dependent protease is *involved* in the [NF-kappaB] activation in neurons in response to N-methyl-d-aspartate receptor occupancy by glutamate . Regulation NFKB1 CAPN8 15688415 1382532 NF-kappaB , a regulator of Bcl-2 expression , and protease activity , a *regulator* of [NF-kappaB] , were both inhibited by RES . Regulation NFKB1 CCND1 15652748 1364329 Mechanistically , the effects of Vav1 require its GEF activity and the activation of Rac1 , PAK1 , and [NF-kappaB] and *involve* upregulation . Regulation NFKB1 CCND1 17008396 1674085 To further understand the mechanism of TNF stimulated growth of primary MEC , the requirement for [NFkappaB1/p50] , and the *role* of in TNF stimulated growth were examined . Regulation NFKB1 CCND1 17944672 1814242 Furthermore , L-685,458 down-regulated , B-cell lymphocytic-leukemia proto-oncogene 2 and c-Myc expressions , which are *regulated* by the transcription factor [NF-kappaB] . Regulation NFKB1 CD14 10996025 733682 In the present study , we investigated the *role* of and complement receptor type 3 (CR3) in mediating NO production and [NF-kappaB/Rel] activation induced by angelan and LPS . Regulation NFKB1 CD14 11546774 882129 In conclusion , H. pylori induced [NF-kappaB] activation in epithelial cells is dependent on cag PAI and contact but does not *involve* and IRAK , whereas in macrophage/monocytic cells it is independent of cag PAI or contact but involves CD14 and TLR4 . Regulation NFKB1 CD14 11779220 900062 *dependent* activation of [NF-kappaB] by filarial parasitic sheath proteins . Regulation NFKB1 CD14 11779220 900069 These observations suggest that the capacity of certain lung epithelial cells to interact with microfilarial antigens , activate [NF-kappaB] in a *dependent* manner and produce pro-inflammatory cytokines may be a contributory factor to immune responses manifested by tropical pulmonary eosinophilia . Regulation NFKB1 CD14 12595465 1061559 The LPS receptor complex utilized by the bladder epithelial cell lines included and Toll-like receptors , and signaling *involved* the activation of [NF-kappaB] and p38 mitogen activated protein kinase . Regulation NFKB1 CD14 16879219 1593891 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by MEK/ERK signaling and [NFkappaB] activation and that membrane bound and TLR-4 are *involved* in this mechanism . Regulation NFKB1 CD14 19840871 2203173 *played* a significant role in the activation of [NF-kappaB] in response to necrotic cells in the presence or absence of TLR2 . Regulation NFKB1 CD14 7876168 298438 The combination of plasma membrane enriched fraction and cytosol was sufficient to activate [NF-kappa B] in a *dependent* manner only in the presence of ATP as judged by the binding of NF-kappa B to the IL-8 gene kappa B site on an electrophoretic mobility shift assay . Regulation NFKB1 CD14 9574560 502564 This study was undertaken to evaluate the *role* of and complement receptors type 3 (CR3) and 4 ( CR4 ) in mediating TNF release and [NF-kappaB] activation induced by LPS and cell wall preparations from group B streptococci type III ( GBS ) . Regulation NFKB1 CTNNAL1 17952117 1889013 , a Rho signalling component , can *regulate* [NF-kappaB] through binding to IKK-beta , and confers resistance to apoptosis . Regulation NFKB1 DAPK1 18292548 1872961 In contrast , IL-1beta- and TNF-alpha triggered [NF-kappaB] activation was not *affected* by . Regulation NFKB1 EDN2 11692473 876499 The subsequent [NF-kappa B] activation probably *involves* participation of signaling and , perhaps , NF-AT3 activation . Regulation NFKB1 EPHB2 11108246 756747 However , TNFalpha induced [NF-kappaB] DNA binding activity is *independent* of p38MAPK and activation . Regulation NFKB1 EPHB2 11773061 916289 Moreover , the NF-kappa B promoter activity decreased with overexpression of dominant negative ERK expression constructs , and EMSA analyses further support the hypothesis that acts upstream of NF-kappa B and *regulates* the [NF-kappa B] DNA binding activity . Regulation NFKB1 EPHB2 12055070 951583 Furthermore , AP-1 and [NF-kappaB] DNA binding was not *affected* by and p38 inhibition . Regulation NFKB1 EPHB2 12068083 955374 PD98059 did not inhibit NF-kappaB binding , demonstrating that was not *responsible* for [NF-kappaB] activation . Regulation NFKB1 EPHB2 12677169 1076928 We demonstrate , for the first time , that glycated albumin activates RAW cell ERK and promotes *dependent* increases in TGF-beta(1) production , oxidative stress , and [NF-kappa B] activation . Regulation NFKB1 EPHB2 15100369 1239796 mRNA expression of MCP-1 was abolished by [NF-kappaB] inhibition , but were not *affected* by the inhibition of , JNK , or p38 . Regulation NFKB1 EPHB2 15147892 1248150 HHE increased the activity of p38 MAPK and extracellular signal regulated kinase ( ERK ) , but not c-jun NH ( 2 ) -terminal kinase , indicating that p38 MAPK and are closely *involved* in HHE induced [NF-kappaB] transactivation . Regulation NFKB1 EPHB2 15670752 1365879 Specifically , TPA induced nuclear translocation of NF-kappaB was effectively attenuated by GF109203X and PD98059 , suggesting PKC and *regulation* of [NF-kappaB] nuclear localization in response to TPA . Regulation NFKB1 EPHB2 16169610 1525420 Activation of [NF-kappaB] was *independent* of and p38 MAP kinase . Regulation NFKB1 EPHB2 16326421 1488358 Together these results suggest that while gamma-IR and Ras both contribute to the upregulation of CD23 expression via NF-kappaB Raf or is not *involved* in gamma-IR induced [NF-kappaB] activation . Regulation NFKB1 EPHB2 17312151 1699697 WT FcgammaRIIA and mutants that associated with lipid rafts efficiently activated [NF-kappaB] , in an *dependent* manner . Regulation NFKB1 EPHB2 18335517 1925146 These data indicate that near-physiological concentrations of Mn potentiate cytokine induced expression of NOS2 and production of NO in astrocytes via activation of sGC , which promotes *dependent* enhancement of [NF-kappaB] signaling . Regulation NFKB1 EPHB2 18442799 1900634 In this study , we show that and p38 MAP kinase are *involved* in the downregulation of cell surface TNF-R1 upon exposure to Ac-CHX and the subsequent inhibition of TNF-alpha induced [NF-kappaB] activation . Regulation NFKB1 EPHB2 20537708 2279378 In conclusion , all these findings demonstrate a key *role* of and TLR4 in association with [NF-kappaB] in IL-10 modulation induced by T. cruzi and suggest that this regulatory effect involves parasite-DC interactions not described yet . Regulation NFKB1 EPHB2 20558745 2302519 rHSP90alpha induced the activities of , PI3K/Akt , and NF-kappaB p65 , but only [NF-kappaB] activation was *involved* in HSP90alpha induced integrin alpha(V) expression . Regulation NFKB1 FAS 11689460 876272 CD40 activation induced , *dependent* apoptosis and [NF-kappaB/AP-1] signaling in human intrahepatic biliary epithelial cells . Regulation NFKB1 FAS 12883671 1116464 However , the *role* of in induction of [NF-kappaB] activation in HCC cells is not well understood . Regulation NFKB1 FAS 16330535 1512011 costimulation of naive CD4 T cells is *controlled* by [NF-kappaB] signaling and caspase activity . Regulation NFKB1 FUT4 17410536 1736255 In an attempt to identify an effective therapeutic agent for pancreatic cancer , the authors studied the *role* of , a synthetic serine protease inhibitor , in the inhibition of [NF-kappaB] activation and the induction of apoptotic responses . Regulation NFKB1 FUT4 17410536 1736277 To examine the *effect* of on the inhibition of [NF-kappaB] and the induction of apoptosis in pancreatic cancer cell lines , Western and Northern blot analyses , electromobility shift ( EMSA ) , luciferase reporter gene , DNA fragmentation , immunoprecipitation , in vitro kinase , small interfering RNA ( siRNA ) , and chromatin immunoprecipitation ( ChIP ) assays were performed . Regulation NFKB1 HES2 20689135 2299300 The infusion of HES130/0.4 in endotoxemic rats , especially 15 ml/kg , significantly reduced the release of plasma TNF-alpha and IL-1beta , which was consistent with the observed inhibitory *effects* of on [NF-kappaB] activation , TLR4 mRNA expression , and TLR4 protein level in monocytes . Regulation NFKB1 IL1B 10336492 615486 The activation of [NF-kappaB] and the subsequent cytokine induced neutrophil chemoattractant induction in *response* to were inhibited by proteasome inhibitors , MG132 and proteasome inhibitor I. Translocation of NF-kappaB into nuclei occurs by the phosphorylation , multi-ubiquitination , and degradation of IkappaBalpha , a regulatory protein of NF-kappaB . Regulation NFKB1 IL1B 10336492 615490 These results indicate that the transient translocation of [NF-kappaB] in *response* to may be partly dependent on transient proteasome activation . Regulation NFKB1 IL1B 10490923 645818 [NF-kappaB] activation in *response* to TNF-alpha , , phorbol ester , and H ( 2 ) O ( 2 ) was down-regulated by polaprezinc . Regulation NFKB1 IL1B 10594073 573026 An essential *role* of in mediating [NF-kappaB] activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia . Regulation NFKB1 IL1B 10605929 655655 Interestingly , transfection of epithelial cells with the 5-LOX and 5-LOX activating protein expression vectors restored ROI production and ROI dependent [NF-kappaB] activation in *response* to . Regulation NFKB1 IL1B 10629862 576467 We also found in IL-1 beta induced CINC expression using cultured C6 glioma cells , the transient translocation of [NF-kappa B] in *response* to is partly dependent on transient proteasome activation . Regulation NFKB1 IL1B 10638662 660335 Genistein , a nonspecific tyrosine kinase inhibitor , also had no effect on mediated *effects* on [NF-kappaB] . Regulation NFKB1 IL1B 10644648 661129 These data suggest that constitutive [NF-kappaB] p65 protein synthesis is *regulated* by , particularly during pregnancy . Regulation NFKB1 IL1B 10657679 664246 However , when the *dependent* induction of [NF-kappa B] was inhibited , the antiapoptotic effect of IL-1 beta was partially reversed , suggesting that NF-kappa B-mediated gene activation is part of the protective mechanism . Regulation NFKB1 IL1B 10766857 684575 We conclude that cellular differentiation of HT-29 cells selectively impairs the IL-1beta signaling pathway inhibiting both [NF-kappaB] and JNK activity in *response* to . Regulation NFKB1 IL1B 10882729 730449 Neither receptor alone was able to mediate transcriptional activation of [NF-kappaB] in *response* to IL-1alpha , , or IL-18 . Regulation NFKB1 IL1B 10942208 721295 Since pro-inflammatory cytokine IL-1beta has been shown to induce prostaglandin E2 ( PGE2 ) release in human gingival fibroblasts (HGF) , here we analyzed the *effect* of on the expression of COX-2 and the activation of [NFkappaB] in HGF . Regulation NFKB1 IL1B 11104703 756492 However , pretreatment with the proteasome inhibitor MG132 under conditions that prevented the *dependent* activation of the nuclear factor [NF-kappaB] also blocked the inhibitory effect of IL-1beta on IL-6 activated STAT1 . Regulation NFKB1 IL1B 11153595 761128 The effect of the antioxidant compound , N-acetyl-L-cysteine (NAC) , on release and *regulation* of [NF-kappaB] in a human myelo-monocytic cell line ( THP-1 ) differentiated into macrophages was studied . Regulation NFKB1 IL1B 11445585 860064 Furthermore , lambda/iotaPKC and cPLA(2) phosphorylation was attenuated by phosphatidyinositol 3-kinase ( PI3-kinase ) inhibitors , which also reduced [NF-kappaB] activation in *response* to TNF-alpha and , indicating a role for PI3-kinase in these processes in human keratinocytes . Regulation NFKB1 IL1B 11976320 953999 CaMKKc and Akt overexpression decreases IRAK1 mediated [NF-kappaB] activity and its association with MyD88 in *response* to stimulation . Regulation NFKB1 IL1B 12588520 1059443 Activation of [NF kappa B] in *response* to was no longer apparent in IL-1RI knockout mice , confirming that this receptor is essential for the transduction of IL-1 signal in the pituitary , but remained after LPS treatment . Regulation NFKB1 IL1B 12670873 1080137 This leads to sustained suppression of induced [NF-kappaB] transcriptional *regulation* of proinflammatory genes . Regulation NFKB1 IL1B 12860389 1111471 *dependent* activation of [NF-kappaB] mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase . Regulation NFKB1 IL1B 12934647 1132846 Salicylate inhibited the and TNF-alpha induced COX-2 expressions , *regulated* the activation of ERK , IKK and IkappaB degradation , and the subsequent activation of [NF-kappaB] , in neonatal rat ventricular cardiomyocytes . Regulation NFKB1 IL1B 14985981 1236679 The *effects* of on the pump and [NF-kappaB] were prevented by the COX inhibitor indomethacin . Regulation NFKB1 IL1B 15240151 1270129 Specifically , IL-1beta induced nuclear translocation of NF-kappaB was in part attenuated by LY294002 , but not by GF109203X , SB203580 , and SP600125 , suggesting PI3K dependent nuclear translocation of [NF-kappaB] in *response* to . Regulation NFKB1 IL1B 15604022 1346801 [NF-kappaB] *responses* to , CD40L , and LPS were donor dependent ( n=7 ) , correlated with the quality of iDC preparations ( p=0.002 ) , and IL-12 p70 production ( p=0.010 ) . Regulation NFKB1 IL1B 15739117 1383023 To test this hypothesis , we compared the *effects* of , high glucose , and hydrogen peroxide , on [NFkappaB] DNA binding activity and target gene mRNA levels in cultured rat islets . Regulation NFKB1 IL1B 16417227 1514518 Pseudomonas aeruginosa- and mediated induction of human beta-defensin-2 in keratinocytes is *controlled* by [NF-kappaB] and AP-1 . Regulation NFKB1 IL1B 17136479 1747053 Investigation of mediated *regulation* of [NF-kappaB] activation in colonic cells reveals divergence between PKB and PDK transduced events . Regulation NFKB1 IL1B 17337443 1726639 IRAK-4 KD cells are severely impaired in [NFkappaB] , JNK , and p38 activation in *response* to or TLR7 ligand . Regulation NFKB1 IL1B 17645739 1793280 However , although Dex did not inhibit the nuclear translocation of p65 [NF-kappaB] in *response* to , it profoundly inhibited NF-kappaB promoter- and HBD-2 promoter-driven luciferase activities . Regulation NFKB1 IL1B 17663801 1780460 In *response* to , or IL10 , the levels of phosphorylated [NF-kappaB] and STAT3 -- respectively -- increased significantly for all the studied cell types . Regulation NFKB1 IL1B 18266467 1896063 Here we demonstrate that ectopic expression of B14 inhibited [NF-kappaB] activation in *response* to TNFalpha , , poly ( I:C ) , and PMA . Regulation NFKB1 IL1B 18510099 1840593 IRAK-4 KD cells were severely impaired in [NF-kappaB] , JNK , and p38 activation in *response* to or TLR7 ligand . Regulation NFKB1 IL1B 19669392 2186114 Determine the *effect* of and dynamic compression on [NFkappaB] activation and IkappaB-alpha gene expression in chondrocyte/agarose constructs . Regulation NFKB1 IL1B 23570163 1506783 [NF-kappaB] *responses* to , CD40L , and LPS were donor dependent ( n = 7 ) , correlated with the quality of iDC preparations ( p = 0.002 ) , and IL-12 p70 production ( p = 0.010 ) . Regulation NFKB1 ITGB2 11701612 878737 *dependent* activation of [NF-kappaB] was potentiated by wild-type , and attenuated by dominant negative , TRAF6- and TGF-beta activated kinase ( TAK1 ) constructs . Regulation NFKB1 ITGB2 9062344 417867 *dependent* oxidative [NF-kappaB] activation leading to nitric oxide production in rat Kupffer cells cocultured with syngeneic hepatoma cells . Regulation NFKB1 MAP2K6 10878013 722403 A constitutive active -- > ERK pathway negatively *regulates* [NF-kappa B-dependent] gene expression by modulating TATA binding protein phosphorylation . Regulation NFKB1 MAP2K6 15688034 1376200 Inhibitors of phosphatidylinositol-3'-kinase and Src family kinases significantly inhibited HGF/SF mediated activation of NF-kappaB , while inhibitors of , protein kinase C , and p70 S6 kinase had a modest effect or no *effect* on [NF-kappaB] activity . Regulation NFKB1 MAP2K6 16034135 1436457 Neither overexpression or inhibition of , Ras , or Akt *affected* HB-EGF mediated inhibition of [NF-kappaB] activation . Regulation NFKB1 MAP2K6 9585425 505223 In contrast , inhibition of and PI3-kinase did not *affect* osteopontin induced [NF-kappaB] activation . Regulation NFKB1 NEDD9 13679070 1140268 Our findings suggest that is *involved* in Casper mediated regulation of apoptosis and [NF-kappaB] activation . Regulation NFKB1 PECAM1 20173029 2215489 To confirm and extend these observations , we examined the *effect* of engaging , cross linking , or expressing on [NF-kappaB] activation in a variety of human cells . Regulation NFKB1 PECAM1 20173029 2215493 had no *effect* on the phosphorylation of the [NF-kappaB] inhibitory protein , IkappaBalpha ; Regulation NFKB1 PTGER2 20516073 2295225 Shear induced interleukin-6 synthesis in chondrocytes : *roles* of and EP3 in cAMP/protein kinase A- and PI3-K/Akt dependent [NF-kappaB] activation . Regulation NFKB1 RCAN1 17062574 1654648 To elucidate the molecular basis of these anti-inflammatory effects , we analyzed the *role* of in the regulation of [NF-kappaB] transactivation using glioblastoma cells stably transfected with DSCR1 .4 or its truncation mutants ( DSCR1.4- ( 1-133 ) and DSCR1 .4- ( 134-197 ) ) . Regulation NFKB1 S1PR3 11673450 888519 and Edg-5 , which are coupled to G ( i ) , G ( q ) , and G(13) , *affect* activation of [NF-kappa B] , whereas Edg-1 , which is coupled to G ( i ) alone , does not . Regulation NFKB1 STK39 10485710 644475 Here we show that the Akt is *involved* in the activation of [NF-kappaB] by tumour necrosis factor (TNF) . Regulation NFKB1 TGM2 18804908 2012323 It appears that increased expression of is *responsible* for the constitutive activation of [NF-kappaB] in cancer cells . Regulation NFKB1 TGM2 18923241 1977480 The objective of the present study was to investigate the expression of in the human atherosclerotic human coronary artery , and the possible *roles* of TGase 2 in [NF-kappaB] activation . Regulation NFKB1 TLR7 15571070 1344242 In response to challenge with microbes or microbial derived substances the activation and nuclear translocation of [NF-kappaB] , the production of nitric oxide ( NO ) and inflammatory cytokines occur in keratinocytes , in a *dependent* manner . Regulation NFKB1 TLR7 16244651 1476914 Furthermore , epithelial cell-surface hyaluronan was protective against apoptosis , in part , through *dependent* basal activation of [NF-kappaB] . Regulation NFKB1 TLR7 16894359 1601079 Lung epithelial cell overexpression of high molecular mass HA protected mice against acute lung injury and apoptosis , in part through *dependent* basal activation of [NF-kappaB] . Regulation NFKB1 TLR7 17100624 1644751 In the intestine , *dependent* activation of [NF-kappaB] plays a vital role in maintaining epithelial homeostasis as well as regulating infections and inflammation , while dysregulation of TLR signaling is associated with the pathogenesis of inflammatory bowel diseases (IBD) . Regulation NFKB1 TNF 10195897 604193 Mouse embryonic fibroblast cells that were isolated from IKK2-/- embryos showed a marked reduction in tumor necrosis factor-alpha (TNF-alpha)- and interleukin-1alpha induced [NF-kappaB] activity and an enhanced apoptosis in *response* to . Regulation NFKB1 TNF 10367939 561446 In the present study , we have investigated the *effects* of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ) , interleukin-10 (IL-10) and -13 ( IL-13 ) , transforming growth factor-beta1 ( TGF-beta1 ) , granulocyte-macrophage colony stimulating factor ( GM-CSF ) , and on cell proliferation and induction of transcription factors AP-1 and [NF-kappaB] in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro . Regulation NFKB1 TNF 10490923 645817 [NF-kappaB] activation in *response* to , IL-1beta , phorbol ester , and H ( 2 ) O ( 2 ) was down-regulated by polaprezinc . Regulation NFKB1 TNF 10524940 653866 In normal human urothelial cells , activation of the [NF-kappaB] complex in *response* to stimulation with , LPS , and dsRNA was detected by immunohistochemical methods and EMSA . Regulation NFKB1 TNF 10532402 562331 Peroxides , therefore , possibly play an important part in the redox-sensitive pathway of *dependent* [NF-kappaB] activation in canine skin . Regulation NFKB1 TNF 10564845 567347 The system successfully simulated the molecular process steps underlying outcomes of eight different molecular genetics laboratory experiments , including those dealing with [NF-kappaB] and AP-1 regulation in immunodeficiency virus infection and *responses* . Regulation NFKB1 TNF 10728675 678160 In the progenitor B lymphocyte model FL5.12 , whereas [NF-kappaB] has an antiapoptotic function in *response* to , cytokine withdrawal causes nuclear translocation of NF-kappaB/cRel , where it is apoptogenic . Regulation NFKB1 TNF 10766741 684458 NEMO/IKKgamma-deficient primary murine embryonic fibroblasts ( MEFs ) lack detectable [NF-kappaB] DNA binding activity in *response* to , IL-1 , LPS , and Poly ( IC ) and do not show stimulus dependent IkappaB kinase activity , which correlates with a lack of phosphorylation and degradation of IkappaBalpha . Regulation NFKB1 TNF 10766844 684551 The Drosophila receptor associated factor-1 ( DTRAF1 ) interacts with Pelle and *regulates* [NFkappaB] activity . Regulation NFKB1 TNF 10849440 701176 TAF(II)105 , a substoichiometric coactivator subunit of TFIID , is important for activation of anti-apoptotic genes by [NF-kappaB] in *response* to the cytokine . Regulation NFKB1 TNF 10940316 721034 [NFkappaB] activation in *response* to and bleomycin , the latter causing topoisomerase II-independent DNA damage , was intact in both cell lines . Regulation NFKB1 TNF 10963848 727473 We also demonstrate that histaglobin inhibits the nuclear translocation of [NF-kappaB] in *response* to or lipopolysaccharide (LPS) in bone marrow derived macrophages of Balb/c mice . Regulation NFKB1 TNF 10976991 729649 In the present study , we investigated effects of a synthetic glucocorticoid , dexamethasone ( Dex ) , on *dependent* activation of [NF-kappaB] and expression of the ICAM-1 gene . Regulation NFKB1 TNF 10976991 729653 Electrophoretic mobility shift assay ( EMSA ) revealed that *dependent* activation of [NF-kappaB] was almost completely suppressed by Dex treatment . Regulation NFKB1 TNF 11006087 735183 Pyrrolidine dithiocarbamate inhibits *dependent* activation of [NF-kappaB] by increasing intracellular copper level in human aortic smooth muscle cells . Regulation NFKB1 TNF 11006087 735187 In the present study , we investigated effects of PDTC and another antioxidant , N-acetyl-l-cysteine (NAC) , on *dependent* activation of [NF-kappaB] in human aortic smooth muscle cells ( HASMC ) . Regulation NFKB1 TNF 11006087 735197 These results indicate that TNF-alpha dependent expression of MCP-1 in HASMC is tightly regulated by NF-kappaB and that intracellular copper level is crucial for the *dependent* activation of [NF-kappaB] in HASMC . Regulation NFKB1 TNF 11007940 735633 The promoter regions of the human gamma-GCS subunits contain AP-1 , [NF-kappa B] , and antioxidant response elements and are *regulated* by oxidants , growth factors , inflammatory cytokine , and anti-inflammatory agent ( dexamethasone ) in lung cells . Regulation NFKB1 TNF 11009421 735895 A20-deficient cells fail to terminate induced [NF-kappaB] *responses* . Regulation NFKB1 TNF 11009421 735900 Thus , A20 is critical for limiting inflammation by terminating induced [NF-kappaB] *responses* in vivo . Regulation NFKB1 TNF 11104733 756510 Accordingly , we examined the *effects* of and cAMP on the regulation of [nuclear factor (NF)-kappaB] , a transcription factor known to modulate cytokine synthesis in numerous cell types . Regulation NFKB1 TNF 11112449 757637 *dependent* activation of [NF-kappa B] in human osteoblastic HOS-TE85 cells is repressed in vector averaged gravity using clinostat rotation . Regulation NFKB1 TNF 11112449 757641 Effects of vector averaged gravity on *dependent* activation of [nuclear factor kappa B (NF-kappa B)] in human osteoblastic HOS-TE85 cells were investigated by culturing the cells using clinostat rotation ( clinorotation ) . Regulation NFKB1 TNF 11112449 757645 Electrophoretic mobility shift assays revealed that *dependent* activation of [NF-kappa B] was markedly reduced in the clinorotated cells when compared with the cells in control stationary cultures or after horizontal rotation ( motional controls ) . Regulation NFKB1 TNF 11112449 757649 Consistent with these findings , the *dependent* induction of endogenous [NF-kappa B-responsive] genes p105 , I kappa B-alpha , and IL-8 , was significantly attenuate in clinorotated cells . Regulation NFKB1 TNF 11133232 769110 Importantly , expression of I kappa B ( S32A , S36A ) results in complete abrogation of myocardial [NF-kappa B] activation in *response* to and LPS stimulation . Regulation NFKB1 TNF 11198351 779642 The *effects* of on DNA binding activity of [NF-kappaB] and expression of mRNA encoding ICAM-1 ( an NF-kappaB activated gene ) were studied in human pulmonary artery endothelial ( HPAE ) cells under basal conditions and after decreasing the intracellular glutathione ( GSH ) concentration . Regulation NFKB1 TNF 11198351 779653 Exposure of BSO treated cells to the reducing agent dithiothreitol ( DTT ) before TNFalpha treatment or supplementation of nuclear extract ( isolated after TNFalpha challenge of BSO treated cells ) with DTT significantly augmented the *effect* of on [NF-kappaB] binding activity and ICAM-1 mRNA expression . Regulation NFKB1 TNF 11262181 796270 This indicates that isoprenylated regulatory proteins participate in the *regulation* of [NF-kappaB] by DNA damaging agents as well as by . Regulation NFKB1 TNF 11274209 819037 However , the signal transduction pathways regulating [NF-kappaB] activation in human neutrophils in *response* to stimulation with are undefined . Regulation NFKB1 TNF 11306890 804342 In an in vitro ICT model we show that pretreatment of RCC with IL-2 and IFNalpha leads to a diminished [NF-kB] *response* to . Regulation NFKB1 TNF 11309390 820013 Activation of [NF-kappaB] in *response* to and glutamate was completely abolished when IP ( 3 ) receptors were blocked , and NF-kappaB activation in response to depletion of ER calcium by thapsigargin treatment was also decreased by IP ( 3 ) receptor blockade . Regulation NFKB1 TNF 11316733 806521 In contrast to the *effect* of on [NF-kappaB] activation , Western blot analyses demonstrated that IGF-I had no effect on IkappaB phosphorylation and degradation or nuclear translocation and DNA binding of NF-kappaB . Regulation NFKB1 TNF 11337489 827582 Taken together , this evidence strongly suggests that EGFR transactivation by , which is regulated in a redox dependent manner , is playing a pivotal *role* in TNF induced [NF-kappa B] activation . Regulation NFKB1 TNF 11382928 820953 However , in transformed MEC , [NFkappaB] binding was initially undetectable but then increased in *response* to . Regulation NFKB1 TNF 11420300 830590 Moreover , it seems that Ref-1 may act as a critical cofactor , mediating the induced [NF-kappaB] *response* in the vascular endothelium . Regulation NFKB1 TNF 11420928 830779 *dependent* [NF-kappa B] activation in cultured canine keratinocytes is partly mediated by reactive oxygen species . Regulation NFKB1 TNF 11445585 860030 Atypical lambda/iota PKC conveys 5-lipoxygenase/leukotriene B4-mediated cross-talk between phospholipase A2s regulating [NF-kappa B] activation in *response* to and interleukin-1beta . Regulation NFKB1 TNF 11445585 860039 We have shown previously that secretory nonpancreatic ( snp ) and cytosolic ( c ) phospholipase A(2) ( PLA(2) ) regulate [NF-kappaB] activation in *response* to or interleukin (IL)-1beta activation and that a functional coupling mediated by the 5-lipoxygenase (5-LO) metabolite leukotriene B ( 4 ) ( LTB ( 4 ) ) exists between snpPLA ( 2 ) and cPLA(2) in human keratinocytes . Regulation NFKB1 TNF 11445585 860063 Furthermore , lambda/iotaPKC and cPLA(2) phosphorylation was attenuated by phosphatidyinositol 3-kinase ( PI3-kinase ) inhibitors , which also reduced [NF-kappaB] activation in *response* to and IL-1beta , indicating a role for PI3-kinase in these processes in human keratinocytes . Regulation NFKB1 TNF 11505050 847906 Pretreatment of HepG2 cells with IFNalpha resulted in the highest levels of [NF-kappaB] activation in *response* to or TNFalpha plus ethanol stimulation . Regulation NFKB1 TNF 11699072 878325 To determine the role of the human coronary artery endothelial cell ( HCA-EC ) in the cytokine response to endotoxin we measured in vitro synthesis , TNF-alpha mRNA , and the associated [NF-kappa B] *response* to LPS . Regulation NFKB1 TNF 12032830 948137 Therefore , MnSOD expression is induced by [NF-kappaB] in epithelial cancer cells in *response* to , and is at least partially responsible for their resistance to TNF-alpha induced apoptosis , presumably through the clearance of death inducing ROS . Regulation NFKB1 TNF 12133965 967046 Mitogen activated protein kinases and [NF-kappa B] are involved in *responses* to group B streptococci . Regulation NFKB1 TNF 12143039 969601 *dependent* activation of [NF-kappa B] induces the transcription of antiapoptotic genes that renders liver cells resistant against TNF induced apoptosis . Regulation NFKB1 TNF 12391248 1007497 The possible *participation* of generated by mast cells in [NF-kappaB] activation by anti-IgE was investigated using a blocking Ab for TNF-alpha . Regulation NFKB1 TNF 12411493 1010845 Siah2 efficiently decreases *dependent* induction of JNK activity and transcriptional activation of [NF-kappaB] . Regulation NFKB1 TNF 12431991 1037096 We propose that the biphasic activation of [NF-kappaB] in *response* to may play a key regulatory role in skeletal muscle wasting associated with cachexia . Regulation NFKB1 TNF 12543078 1028767 Together , the p43 induced production was *controlled* by [NFkB] , p38 MAPK , and ERK that is dependent on the activities of PLC and PKC . Regulation NFKB1 TNF 12586352 1059021 Among others , the NF-kappa B-dependent zinc finger protein A20 is involved in the negative feedback regulation of [NF-kappa B] activation in *response* to . Regulation NFKB1 TNF 12704649 1082364 In analogy with *dependent* activation of [NFkappaB] , treatment with either the anti-oxidant N-acetyl cysteine (NAC) or the cyclooxygenase (COX) inhibitor acetyl salicylic acid ( aspirin ) , but not indometacin , prevents the induction of NFkappaB dependent transcription by AII . Regulation NFKB1 TNF 12706343 1082636 Activation of [NF-kappaB] in *response* to was intact in both cell lines . Regulation NFKB1 TNF 12709429 1112682 The *role* of receptor associated factor ( TRAF)-1 in [NF-kappaB] activation by various members of the TNF receptor family is not well understood , and conflicting data have been published . Regulation NFKB1 TNF 12709443 1100429 Using various deficient mouse embryonic fibroblast cells , we have compared the signaling pathways leading to [NF-kappaB] induction in *response* to and LTbetaR activation . Regulation NFKB1 TNF 12816868 1140929 Although expression of mutant IkappaBalpha inhibited the induced [NF-kappaB] *response* , it had no effect on tumor growth in mice . Regulation NFKB1 TNF 12882985 1142763 Absence of apolipoprotein J causes reduction of IkappaB stability , a *dependent* increase in [NF-kappaB] activity , increased transcription of the NF-kappaB target gene c-IAP and down-modulation of p53 protein . Regulation NFKB1 TNF 14557256 1185997 receptor associated factor ( TRAF) 1 *regulates* CD40 induced TRAF2 mediated [NF-kappaB] activation . Regulation NFKB1 TNF 14607933 1162130 *dependent* activation of [NF-kappaB] is stronger in the presence of IFN-gamma . Regulation NFKB1 TNF 14674885 1211099 The introduction of calcium into HEK293 cells either through the activation of muscarinic cholinergic receptors or through the application of the ionophore A23187 was found to enhance *dependent* activation of [NF-kappaB] . Regulation NFKB1 TNF 14692400 581722 In this report , we investigated the *effect* of on activation of [NF-kappa B] , c-Jun N-terminal kinase (JNK) , and apoptosis in vincristine-resistant human histiocytic lymphoma U937-VR cells . Regulation NFKB1 TNF 15001576 1236987 The receptor associated factor ( TRAF ) protein family members are critically *involved* in activation of [NF-kappaB] , JNK , and p38 activation triggered by tumor necrosis factor (TNF) receptor family members and toll/interleukin-1 receptor ( TIR ) -containing receptors . Regulation NFKB1 TNF 15115707 1279366 Both kinases associate with TNFR-1 in *response* to and are required for TNFR-1 serine phosphorylation , [NF-kappaB] activation , and inhibition of apoptosis . Regulation NFKB1 TNF 15158369 1252592 In ECV304 cells overexpressing ERalpha , E ( 2 ) significantly inhibited the *effects* of on [NF-kappaB] activation , VCAM-1 expression , and U937 cell adhesion . Regulation NFKB1 TNF 15526279 1360031 Molecular approaches to either reduce EC MLCK expression ( AdV EC MLCK antisense construct ) or to reduce kinase activity ( kinase-dead EC MLCK ATPdel mutant ) produced similar attenuation of the induced [NFkappaB] *response* . Regulation NFKB1 TNF 15653317 1364400 Recently , the underlying mechanism by which A20 downregulates [NF-kappaB] activation in *response* to the pro-inflammatory cytokine has been described . Regulation NFKB1 TNF 15833158 1397584 In IP , mutations in NEMO lead to the complete loss of [NF-kB] activation creating a susceptibility to cellular apoptosis in *response* to . Regulation NFKB1 TNF 15870274 1404481 A prominent function of p62 is the regulation of [NF-kappaB] activation in *response* to interleukin-1 (IL-1) and signaling through the formation of an aPKC/p62/TRAF6 multiprotein signaling complex . Regulation NFKB1 TNF 16186825 1468301 TAK1-deficient cells failed to activate transcription factor [NF-kappaB] and mitogen activated protein kinases in *response* to interleukin 1beta , and Toll-like receptor ligands . Regulation NFKB1 TNF 16191192 1468318 In *response* to , latent cytoplasmic [NF-kappaB] is activated , enters the nucleus , and induces expression of inflammatory and anti-apoptotic gene expression programs . Regulation NFKB1 TNF 16203735 1483204 Reducing Monarch-1 expression with small interference RNA in myeloid/monocytic cells caused a dramatic increase in [NFkappaB] activation and cytokine expression in *response* to TLR2/TLR4 agonists , , or M. tuberculosis infection , suggesting that Monarch-1 is a negative regulator of inflammation . Regulation NFKB1 TNF 16288994 1484467 These results suggest that the inhibitory effect of equol on TNF-alpha expression is mediated , at least in part , by blocking [NF-kappaB] activation and the inhibition of expression by equol might be *involved* in its osteoprotective effect . Regulation NFKB1 TNF 16318585 1487692 Further , NF-kappaB and Stat1 proteins directly regulate transcription by interacting cooperatively on [NF-kappaB-SIE] DNA binding in *response* to plus IFN-gamma . Regulation NFKB1 TNF 16481354 1528463 Furthermore , the similarity between the phenotypes of c ( IkappaBADeltaN ) mice and mice deficient in Eda A1 ( tabby ) or its receptor EdaR ( downless ) raised the issue of whether in vivo [NF-kappaB] regulates or is *regulated* by these novel family members . Regulation NFKB1 TNF 16644735 1583269 Mechanistically , our data indicated that , in *response* to , [NFkappaB/p65] phosphorylation and translocation as well as IkappaBalpha phosphorylation and degradation were unchanged , suggesting that Lnk does not modulate NFkappaB activity . Regulation NFKB1 TNF 16870149 1593093 In addition , our data show that the early expression of TNF-alpha does not lead to activation of NF-kappaB , because disruption of activity by a neutralizing antibody does not *affect* nuclear translocation of [NF-kappaB] , IkappaBalpha degradation or reporter gene activation by apicidin . Regulation NFKB1 TNF 17363555 1712974 We now report that cancer associated mutant p53 can augment the induction of [nuclear factor kappaB (NFkappaB)] transcriptional activity in *response* to the cytokine . Regulation NFKB1 TNF 17537988 1784162 This novel finding supports a model , whereby *dependent* activation of [NF-kappaB] up-regulates phagocyte NADPH oxidase activity , leading to enhanced ROS production and further NF-kappaB activation , potentially contributing to sustained oxidant production in chronic inflammation . Regulation NFKB1 TNF 17784835 1790512 Nuclear localization of [NF-kappaB] in *response* to was evident in differentiated , but not undifferentiated , SNUhES3 cells . Regulation NFKB1 TNF 17878386 1797059 Furthermore , in contrast to the full-length protein , CARD8-S did not modify the expression of [NF-kappaB] target genes ( cIAP , A1 ) , in *response* to . Regulation NFKB1 TNF 17897950 1824002 However , down-regulation of USP11 dramatically enhances [NF-kappaB] activity in *response* to , indicating that IKKalpha does not require activation of NF-kappaB . Regulation NFKB1 TNF 17975552 1850196 We show in this study that R-Roscovitine can downregulate [nuclear factor-kappa B (NF-kappaB)] activation in *response* to and interleukin 1 . Regulation NFKB1 TNF 18178551 1875722 Thus we conclude that endogenous Cezanne can attenuate [NF-kappaB] activation and the induction of pro-inflammatory transcripts in *response* to signaling . Regulation NFKB1 TNF 18207479 1876660 These data demonstrate that *plays* a role in [NF-kappaB] activation and toxicity . Regulation NFKB1 TNF 18266467 1896062 Here we demonstrate that ectopic expression of B14 inhibited [NF-kappaB] activation in *response* to , IL-1beta , poly ( I:C ) , and PMA . Regulation NFKB1 TNF 18446055 1902767 Finally , pretreatment with pyrrolidine dithiocarbamate ( PDTC ) , an inhibitor of NF-kappaB , reduced TNF-alpha induced ICAM-1 expression and both DPI and RacN17 significantly diminished [NF-kappaB] activation in *response* to . Regulation NFKB1 TNF 18562480 1946209 The data presented herein suggest a model whereby the TNF R1-IRAK-1 interaction integrates the cellular response to LPS , TNF-alpha , and IL-1 , culminating in a cell poised to activate *dependent* [NF-kappaB] controlled gene expression . Regulation NFKB1 TNF 18599677 1966151 In the present review we summarize recent experimental data suggesting that mitochondrial production of reactive oxygen species , innate immunity , the local , and the renin-angiotensin system may *underlie* [NF-kappaB] induction and endothelial activation in aged arteries . Regulation NFKB1 TNF 18676814 1943476 Encoding [NF-kappaB] temporal control in *response* to : distinct roles for the negative regulators IkappaBalpha and A20 . Regulation NFKB1 TNF 18782567 1975929 The electromobility shift assay showed that while Cl1-0 cells exhibited low [NF-kappaB] activity in *response* to , an abundance of basal and TNF-alpha induced NF-kappaB-DNA complex was detected in Cl1-5 cells . Regulation NFKB1 TNF 19033441 2022958 Functional complementation assays and in vivo pull-down experiments further show that ZF residues involved in ubiquitin binding are functionally important and required for [NF-kappaB] signaling in *response* to . Regulation NFKB1 TNF 19144181 2079142 induced *regulation* of Sox9 and [NFkappaB] activity was also U0126 insensitive . Regulation NFKB1 TNF 19273093 2045773 By employing TNF-alpha / IFN-gamma synergism model which causes beta -cell apoptosis , we found that the antiapoptotic X-linked inhibitor of apoptosis (XIAP) molecule is upregulated by [NF-kappaB] in *response* to and XIAP induction was inhibited by IFN-gamma induced signal transducer and activator of transcription-1 ( STAT1 ) activation , which explains the death of beta -cells by TNF-alpha /IFN-gamma synergism . Regulation NFKB1 TNF 19302817 2064276 DNA binding activity of [NF-kappaB] , a well-known molecular effector of TNFalpha , was moreover activated by Lp(a) in a *dependent* manner and the use of the NF-kappaB inhibitor Bay 11-7082 blocked Lp(a) triggered CCL1 induction . Regulation NFKB1 TNF 19336568 2056507 Tumor necrosis factor (TNF) receptor associated factor 2 ( TRAF2 ) is an adaptor protein that modulates the activation of the c-Jun NH ( 2 ) terminal kinase ( JNK ) /c-Jun and IkappaB kinase [(IKK)/nuclear factor-kappaB (NF-kappaB)] signaling cascades in *response* to stimulation . Regulation NFKB1 TNF 19347279 2057481 We describe in this chapter three separate methods to determine the effects of this NEMO binding domain (NBD) peptide on pro-inflammatory [NF-kappaB] signaling in *response* to . Regulation NFKB1 TNF 19444283 2114796 In this study , we found that p53 upregulated modulator of apoptosis ( PUMA ) , a p53 downstream target and a BH3-only Bcl-2 family member , is directly regulated by [NF-kappaB] in *response* to . Regulation NFKB1 TNF 19927158 2203745 Furthermore , several cell types from E18 RIPK1 ( -/- ) embryos seem to activate [NF-kappaB] in *response* to . Regulation NFKB1 TNF 20071450 2194130 Because the pathomechanism of TRAPS may involve aberrant TNF mediated intracellular signalling , we examined phosphorylation levels of [nuclear factor kappaB (NF-kappaB)] and p38 in *response* to in 10 patients with three different TNFRSF1A mutations ( C73R , C88Y and F112I ) . Regulation NFKB1 TNF 20195534 2216373 Analysis of [NF-kappaB] activation in *response* to in MEFs reveals that IKKbeta is essential for efficient phosphorylation and subsequent degradation of IkappaB alpha , yet IKKalpha contributes to the NF-kappaB activation response in these cells as measured via DNA binding assays . Regulation NFKB1 TNF 20231278 2254522 Maml1-deficient mouse embryonic fibroblasts showed impaired induced [NF-kappaB] *responses* . Regulation NFKB1 TNF 20478530 2263057 TAK1 mediated cancer suppression is exerted through activating [NF-kappaB] in *response* to and through preventing Caspase-3 dependent hepatocyte and cholangiocyte apoptosis . Regulation NFKB1 TNF 20550880 2279632 Up-regulating the expression of occludin and down *regulating* the expressions of TLR4 and [NF-kappaB] , and hence inhibiting expression and improving the mucosa barrier function may be part of the mechanisms of BWXLS in treating oxazolone induced colitis in mice . Regulation NFKB1 TNF 21601601 2464269 TAK1 mediated cancer suppression is exerted through activating [NF-kappaB] in *response* to and through preventing Caspase-3 dependent hepatocyte and cholangiocyte apoptosis . Regulation NFKB1 TNF 23174100 2700544 Our results showed that TNF-alpha treatment increased Bcl-2 mRNA and protein levels in breast cancer cells , suggesting that Bcl-2 is directly regulated by [nuclear factor-kappaB (NF-kappaB)] in *response* to . Regulation NFKB1 TNF 7532017 286151 Under our conditions , all three IFNs potentiated the cytotoxic effects of TNF but had no effect on the *dependent* [NF-kappa B] activation . Regulation NFKB1 TNF 7642536 317969 Here we examine the inductions of [NF-kappa B] in serum deprived and cycling cells in *response* to . Regulation NFKB1 TNF 7929839 274675 Both PDTC and HMAP attenuated the increase in nuclear [NF-kB] in *response* to either or IgG complexes . Regulation NFKB1 TNF 7929839 274679 Preincubation of cells with 8 br-cAMP , forskolin , or PGE2 attenuated the increase in nuclear [NF-kB] in *response* to , aggregated IgG , or superoxide anion . Regulation NFKB1 TNF 7957109 278011 Micromolar amounts of the peptide Cbz-Ile-Glu ( O-t-Bu ) -Ala-leucinal ( PSI ) , a specific inhibitor of the chymotrypsin-like activity of the proteasome , prevented activation of [NF-kappa B] in *response* to and okadaic acid ( OA ) through inhibition of I kappa B-alpha degradation . Regulation NFKB1 TNF 7981153 281395 Furthermore , activation of [NFkB] was also induced in NPD type A fibroblasts in *response* to IL-1 alpha and stimulation to a similar extent as in normal fibroblasts . Regulation NFKB1 TNF 8349660 227108 C2-ceramide , however , enhanced activation of [NF-kappa B] in *response* to with peak effects observed at a concentration of C2-ceramide of 5 microM . Regulation NFKB1 TNF 8521084 336410 However several questions regarding the molecular mechanisms involved in particular steps of these cascades remain largely unresolved : how and at which subcellular level , do the cells produce these reactive oxygen intermediates that will contribute to [NF kappa B] activation in *response* to IL-1 or ? Regulation NFKB1 TNF 8655581 366982 We report here that both kappa B-dependent transactivation of a reporter gene and [NF-kappa B] activation in *response* to ( TNF alpha ) or H2O2 treatments are deficient in human T47D cell transfectants that overexpress seleno-glutathione peroxidase ( GSHPx ) . Regulation NFKB1 TNF 8724035 373771 An enhanced [nuclear factor (NF)-kappa B] activation in *response* to has been observed in stably tat transfected cells . Regulation NFKB1 TNF 8804426 382178 [NF-kappa B-mediated] *regulation* of urokinase gene expression by PMA and in human A549 cells . Regulation NFKB1 TNF 8831497 385731 However , the intracellular signaling pathways that activate endothelial [NF-kappa B] and JNK in induced *responses* are unknown . Regulation NFKB1 TNF 8849369 359030 To examine whether [nuclear factor kappaB (NF-kappaB)] is activated in cultured synovial cells in *response* to and to investigate the correlation between NF-kappaB activation and synovial cell proliferation . Regulation NFKB1 TNF 8852698 387844 Analysis of DNA binding revealed that [NF-kappa B] activation in *response* to was significantly inhibited under these conditions . Regulation NFKB1 TNF 8947041 400456 We have created mutant cell lines that are unable to activate [NF-kappaB] in *response* to . Regulation NFKB1 TNF 9126284 426481 This pretreatment also inhibited activation of [NF-kappa B] in *response* to in lymphoblastoid J.Jhan5-1 cells . Regulation NFKB1 TNF 9310124 454811 Exogenous and the monoclonal antibody to TNF-alpha did not *affect* IL-10 production and constitutive [NF-kappa B] binding levels in HuT 78 cells . Regulation NFKB1 TNF 9351830 466080 Microinjection of the inhibitory peptides into stimulated cells abolished [NF-kappa B] activation in *response* to and the consequent expression of E-selectin , an NF-kappa B-dependent cell-adhesion molecule . Regulation NFKB1 TNF 9383399 345227 Cell lines stably overexpressing the H2O2 degrading enzyme catalase were deficient in activating [NF-kappa B] in *response* to or okadaic acid . Regulation NFKB1 TNF 9501011 491006 We demonstrate that adenovirus mediated overexpression of I kappa B alpha , an inhibitor of [NF-kappa B] suppresses the expression of piap in *response* to suggesting that piap is one of the NF-kappa B regulated genes that operates to prevent programmed cell death of EC in inflammation . Regulation NFKB1 TNF 9506462 491344 *dependent* activation of [NF-kappaB] could be blocked partially by both anti-p60 and anti-p80 , suggesting that TNF mediates its effect independently through the p60 and p80 receptors . Regulation NFKB1 TNF 9528954 496212 The present study examined the *effects* of on the activation of [nuclear factor-kappa B (NF-kappaB)] and on the expression of interleukin (IL)-6 gene in rat thyroid FRTL-5 cells . Regulation NFKB1 TNF 9580637 504960 N-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) , a serine protease inhibitor , inhibited I kappa B-alpha degradation and [NF-kappa B] activation in *response* to in a dose dependent manner ( 25 , 50 , 100 microM ) . Regulation NFKB1 TNF 9624136 511363 Furthermore , the *effect* of on [NFkappaB] activation was rapid , whereas C2-ceramide required an optimal treatment time of 1 h. Interestingly , TNF was found to increase ceramide in cells but only after a 1-h contact time . Regulation NFKB1 TNF 9718198 528173 We thus examined the *effect* of on the activation of [NF-kappaB] in rat osteoblast-like osteosarcoma cells ( ROS17/2.8 ) . Regulation NFKB1 TNF 9724652 529509 Moreover , inhibition of TAFII105 activity by overexpression of a dominant negative mutant of TAFII105 decreased [NF-kappaB] transcriptional activity and severely reduced cell survival in *response* to . Regulation NFKB1 TNF 9819420 547292 MEKK1 is activated by tumor necrosis factor alpha (TNF-alpha) and interleukin-1 and can potentiate the stimulatory *effect* of on IKK and [NF-kappaB] activation . Regulation NFKB1 TNF 9823429 549006 We found that resistance to increasing concentrations of 9NC correlated with resistance to *dependent* activation of [NF-kappa B] . Regulation NFKB1 TNFSF10 10807904 736600 Taken together , our data suggest that TRAIL-R1 responds to either cross linked or non-cross linked sTRAIL which signals NF-kappaB activation and apoptosis , whereas TRAIL-R2 signals [NF-kappaB] activation , apoptosis , and JNK activation only in *response* to cross linked . Regulation NFKB1 TNFSF10 11313369 805412 Furthermore , studies with NF-kappaB reporter constructs revealed that the resistance of melanoma lines to TRAIL induced apoptosis was correlated to activation of [NF-kappaB] in *response* to . Regulation NFKB1 TNFSF10 15498932 1325589 *effects* on mitochondrial [NF-kappaB-DNA] binding and mitochondrial genome encoded mRNA levels also depend on Bcl-2 overexpression . Regulation NFKB1 TNFSF10 16024612 1435233 Specifically , it is not yet understood how *controls* [nuclear factor kappaB (NF-kappaB)] activation and overcomes its anti-apoptotic effect . Regulation NFKB1 TNFSF10 16645643 1672030 Both addition of IGFBP-3 protein to cell cultures or enforced expression of IGFBP-3 in the HT29 carcinoma cell line inhibited [nuclear factor kappa B (NF-kappaB)] activation in *response* to the induction of apoptosis by . Regulation NFKB1 TNFSF10 16785986 1645938 In these cells , the predominant *effect* of receptor activation is the activation of [nuclear factor-kappaB (NF-kappaB)] , which promotes tumor metastases and invasion . Regulation NFKB1 TNFSF10 20354842 2260907 In the present work , we analyzed cell viability , DISC formation as well as IL-8 and [NF-kappaB] activation side by side in *responses* to and agonistic antibodies against DR4 ( mapatumumab ) and against DR5 ( lexatumumab ) in pancreatic ductal adenocarcinoma cells . Regulation NFKBIA CAPN8 15202778 1261031 The results suggest that *plays* an important role in [IkB alpha] degradation , a crucial event in T cell activation . Regulation NFKBIA CAPN8 16938483 1615411 Moreover , in these conditions , we demonstrated formation of the IkappaBalpha/calpain 3 complex and an increase in *dependent* [IkappaBalpha] cleavage products in cell nuclei . Regulation NFKBIA EPHB2 14581482 1186938 Inhibition of did not *affect* interleukin-1beta induced [I-kappaBalpha] phosphorylation and degradation but attenuated I-kappaBbeta degradation . Regulation NFKBIA EPHB2 18218857 1884142 We found that S. aureus and Pam3Cys stimulate phosphorylation of JNK , p38 MAPK , and ERK within 4 h and that blockade of JNK , but not p38 or phosphorylation , had an inhibitory *effect* on [IkBalpha] degradation and CXC chemokine production . Regulation NFKBIA FAS 12934082 1132798 The total levels of p50 , p65 and IkappaBalpha remain unchanged , but the levels of phosphorylated [IkappaBalpha] and of nuclear p65 increase , in *response* to . Regulation NFKBIA IL1B 19669392 2186115 Determine the *effect* of and dynamic compression on NFkappaB activation and [IkappaB-alpha] gene expression in chondrocyte/agarose constructs . Regulation NFKBIA TLR7 18523248 1922770 SP-A decreases the phosphorylation of [IkappaBalpha] , a key regulator of NF-kappaB activity , and nuclear translocation of p65 which result in diminished TNF-alpha secretion in *response* to ligands . Regulation NFKBIA TLR7 23487427 2766602 Genetic variants in the promoter of NFKBIA influenced [NFKBIA] gene expression , I?Ba protein expression , and mediated inflammatory *responses* . Regulation NFKBIA TNF 10353611 617647 The association of p16INK4 with NF-kappaBp65 is considerable in HeLa- or 293 cells , if the NF-kappaB inhibitor [I kappaB alpha] is degraded in *response* to stimulation . Regulation NFKBIA TNF 11519479 851886 In contrast to glial cells , [IkappaBalpha-WT] was degraded in neuronal cells in *response* to but not MV . Regulation NFKBIA TNF 15536134 1336414 Moreover , *dependent* histone H3 acetylation , release of [IkappaBalpha] from the hes1 promoter , and hes1 mRNA synthesis are affected in IKK-alpha ( -/- ) mouse embryonic fibroblasts . Regulation NFKBIA TNF 15637292 1381113 Western blot analysis revealed that , in both the presence and absence of TSH , degradation of a cytosolic kappaB inhibitor ( [IkappaBalpha] ) occurred in *response* to , resulting in nuclear translocation of p65 in both conditions . Regulation NFKBIA TNF 16105945 1448388 The synergistic interaction between fXa and was also *involved* in the inhibition of A20 and [IkappaBalpha] expression in the IkappaB kinase-NF-kappaB pathway . Regulation NFKBIA TNF 16371367 1519660 After [IkappaBalpha] degradation in *response* to , HDAC3 is subject to nuclear translocation , leading to an increase in HDAC3 activity in the nucleus . Regulation NFKBIA TNF 16644735 1583270 Mechanistically , our data indicated that , in *response* to , NFkappaB/p65 phosphorylation and translocation as well as [IkappaBalpha] phosphorylation and degradation were unchanged , suggesting that Lnk does not modulate NFkappaB activity . Regulation NFKBIA TNF 16891465 1597086 We found that treatment of cancer cells with AGRO100 inhibits IKK activity and reduces phosphorylation of [IkappaBalpha] in *response* to stimulation . Regulation NFKBIA TNF 19285159 2072935 *dependent* degradation of [IkappaBalpha] was also suppressed by overexpression of AWP1 and RIO3 , possibly due to the polyubiquitin binding activity of these proteins . Regulation NFKBIA TNF 19429670 2106847 Then , we examined the *effect* of Ang II and/or on phosphorylation of extracellular signal regulated kinase ( ERK ) , p38MAPK , and [IkappaB-alpha] . Regulation NFKBIA TNF 20599928 2290852 In HCT116 cells , CAPE interfered with *dependent* [IkappaBalpha] degradation and subsequent nuclear accumulation of p65 , which occurred by direct inhibition of inhibitory protein kappaB kinase (IKK) . Regulation NFKBIA TNF 7796813 313813 While both endogenous and transiently expressed wild-type [I kappa B-alpha] were proteolytically degraded in *response* to PMA and stimulation of cells , the S32/36A mutant of I kappa B-alpha remained largely intact under these conditions . Regulation NFKBIA TNF 9278272 450845 We examined the *effects* of IR and on HVH1 and [IkappaB alpha] gene expression . Regulation NFKBIA TNF 9580637 504961 N-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) , a serine protease inhibitor , inhibited [I kappa B-alpha] degradation and NF-kappa B activation in *response* to in a dose dependent manner ( 25 , 50 , 100 microM ) . Regulation NFKBIA TNF 9918798 559189 Similarly , stimulation of untransfected L929 cells with TGF-beta1 results in suppression of IkappaB-alpha expression and retarded [IkappaB-alpha] degradation in *response* to . Regulation NFKBIB TNF 9442374 475202 Here we show that in E29.1 T cell hybridoma I kappa B alpha and I kappa B beta are equally associated with p65 and that [I kappa B beta] is degraded in *response* to in contrast to what has been originally published . Regulation NFKBIZ IL1B 16622025 1551551 up-regulation of neutrophil gelatinase associated lipocalin is *controlled* by [IkappaB-zeta] . Regulation NGF EPHB2 11733514 904571 Truncation analysis and electromobility shift assays established the requirement for a cAMP-response element/activating transcription factor-like site in the NFLC promoter that minimally interacts with constitutively expressed cAMP-response element binding protein and JunD as well as c-Jun which is induced by [NGF] in an *dependent* manner . Regulation NGF EPHB2 9390997 467688 Taken together , these data indicate that MEK and may be critically *involved* in protein kinase C and [nerve growth factor] regulation of APP processing . Regulation NGF IL1B 1333537 204441 We have investigated possible mechanisms by which *regulates* [NGF] in hippocampal cells . Regulation NGF IL1B 1333537 204442 Moreover , exposure of hippocampal cultures to Il-1 beta evoked no change in cAMP levels , indicating that this second messenger system played little or no role in the *regulation* of [NGF] expression by in these cells . Regulation NGF IL1B 17413467 1722436 The *effects* of and tumor necrosis factor-alpha (TNF-alpha) on NGF production and mRNA expression of [NGF] by IVD cells were examined . Regulation NGF IL1B 2094822 149978 To examine regulation of NGF gene expression with respect to neural trauma we examined the *effects* of and tumor necrosis factor-alpha (TNF-alpha) on [NGF] production in cultures of rat astroglial cells . Regulation NGF IL1B 2211833 142728 These data indicate that , among other factors , might also *play* a regulatory role in the synthesis of [NGF] in the CNS , as has been demonstrated in the peripheral nervous system ( Lindholm , D. , R. Heumann , M. Meyer , and H. Thoenen . Regulation NGF IL1B 8554509 339996 In contrast , preincubation with PDGF-BB drastically reduces NGF gene expression and [NGF] protein synthesis in *response* to stimulation . Regulation NGF IL1B 9833249 552016 *Role* of and TNF-alpha in the regulation of [NGF] in experimentally induced arthritis in mice . Regulation NGF IL1B 9833249 552018 The aim of this study was to investigate the *effects* of and TNF-alpha on [NGF] levels in the knee joint in experimentally induced arthritis in adult mice . Regulation NGF MAP2K6 16887804 1613857 In a *dependent* manner , [NGF] significantly attenuated rotenone- or colchicine induced microtubule depolymerization and ensuing accumulation of vesicles in the soma and elevation in protein carbonyls . Regulation NGF MMP7 22238106 2538014 *regulates* cleavage of [pro-nerve growth factor] and is neuroprotective following kainic acid induced seizures . Regulation NGF NGFR 3005338 57233 A possible relationship is also suggested between regulation of cAMP responses and *regulation* of [NGF] responses or affinity . Regulation NGF NGFR 8698038 372880 The *role* of the low affinity ( p75 ( NGFR ) ) in [NGF] mediated signaling is not yet understood . Regulation NGF TNF 15322027 1286728 Our experiments were designed to explore the mechanism of effect of L. reuteri in the human epithelial cell lines T84 and HT29 on cytokine and [NGF] synthesis and IL-8 *response* to . Regulation NGF TNF 16956589 1627644 The *role* of and its receptors in the production of [NGF] and GDNF by astrocytes . Regulation NGF TNF 17413467 1722435 The *effects* of interleukin-1beta (IL-1beta) and on [NGF] production and mRNA expression of NGF by IVD cells were examined . Regulation NGF TNF 20350782 2244902 The *effect* of and neutrophil blockade on [NGF] expression and pain were also assessed . Regulation NGF TNF 20690185 2368105 In this study , we investigated the *effects* of inflammatory cytokines , IL-1ß , and , on the expression of an angiogenic factor , vascular endothelial growth factor ( VEGF ) , and neurotrophic factors , [nerve growth factor (NGF)] and brain derived neurotrophic factor (BDNF) , in human IVD degeneration . Regulation NGF TNF 2094822 149977 To examine regulation of NGF gene expression with respect to neural trauma we examined the *effects* of interleukin-1 beta (IL-1 beta) and on [NGF] production in cultures of rat astroglial cells . Regulation NGF TNF 8554509 339995 In contrast , preincubation with PDGF-BB drastically reduces [NGF] gene expression and NGF protein synthesis in *response* to IL-1 stimulation . Regulation NGF TNF 8739030 377057 Although TGF-beta 1 and Activin A stimulated NGF production in Swiss 3T3 cells , they antagonized the stimulatory *effect* of on fibroblast [NGF] production when used in combination . Regulation NGF TNF 9833249 552015 *Role* of IL-1 beta and in the regulation of [NGF] in experimentally induced arthritis in mice . Regulation NGF TNF 9833249 552017 The aim of this study was to investigate the *effects* of IL-1 beta and on [NGF] levels in the knee joint in experimentally induced arthritis in adult mice . Regulation NGFR CA2 8229086 235781 The results indicate that may *play* a role in the expression of the [nerve growth factor receptor] gene during Wallerian degeneration and provide some indication that this effect may be directly on the Schwann cell rather than operating indirectly via the axon . Regulation NGFR CNTF 1309648 178323 is also *involved* in up-regulation of immunostainable low affinity [NGF receptor] ( LNGFR ) in cholinergic medial septum and neostriatal neurons and in a population of lateral septum neurons . Regulation NGFR CNTF 1666130 176500 *Effect* of on low-affinity [NGF receptor] expression by cultured neurons from different rat brain regions . Regulation NGFR CTSB 9602092 506673 Therefore , the *effect* of on [NGF receptor] binding has been examined . Regulation NGFR FYN 22880054 2641735 Whereas Src kinases are often required for Syk activation , we show here that PI3K/Akt activation and autocrine IL-10 production by [NGFR-LMP1] *involves* the Src family kinase . Regulation NGFR HRAS 1604323 189195 These results suggest that the [NGF receptor] system enhances the activities of both the guanine nucleotide exchange factor and GAP and that the activation of might be *controlled* by the balance in activity between these two regulatory proteins . Regulation NGFR KRAS 1604323 189196 These results suggest that the [NGF receptor] system enhances the activities of both the guanine nucleotide exchange factor and GAP and that the activation of might be *controlled* by the balance in activity between these two regulatory proteins . Regulation NGFR NGF 1316918 187837 We have characterized the *effects* of on human B cell proliferation and the regulation of [NGF receptor] expression on these cells . Regulation NGFR NGF 1337936 208045 We examined the *effect* of on the expression of low-affinity [NGF receptor] ( LNGFR ) in cultured P3 basal forebrain cholinergic neurons , on which NGF acts to promote differentiation . Regulation NGFR NGF 1635552 194305 did not interfere with staurosporine binding , and staurosporine did not *affect* [NGF receptor] binding . Regulation NGFR NGF 1660904 171502 The *effect* of on the expression of [nerve growth factor receptor] in the central nervous system of newborn and adult rats was studied by means of immunohistochemistry with the monoclonal antibody 192-IgG . Regulation NGFR NGF 1671048 151272 *Regulation* of [nerve growth factor receptor] gene expression by in the developing peripheral nervous system . Regulation NGFR NGF 1671048 151274 To determine if *regulated* [NGF receptor] gene expression at the transcriptional level , we examined PC12 cells . Regulation NGFR NGF 1671048 151275 These data raise the possibility that transcriptional *regulation* of [NGF receptor] gene expression by target derived could be a molecular mechanism for potentiating NGF 's effects on neurons during developmental periods of neuronal competition and cell death . Regulation NGFR NGF 9795112 543203 The timing of mRNA expression after injury and the phenotype of identified trigeminal neurons suggests a complex signaling cascade in which at the injury site *regulates* [NGF receptor] expression at the levels of the cell body as well as increases in BDNF expression . Regulation NGFR NRAS 1604323 189197 These results suggest that the [NGF receptor] system enhances the activities of both the guanine nucleotide exchange factor and GAP and that the activation of might be *controlled* by the balance in activity between these two regulatory proteins . Regulation NGFR NTF3 9038213 415418 These results suggest that the NGF effect is mediated by the high affinity [NGF receptor] , Trk A and that binding to the low affinity neurotrophin receptor , p75(NTR) , alone does not *affect* the promoter activity . Regulation NGFR NTF4 9038213 415419 These results suggest that the NGF effect is mediated by the high affinity [NGF receptor] , Trk A and that binding to the low affinity neurotrophin receptor , p75(NTR) , alone does not *affect* the promoter activity . Regulation NGFR POU4F1 12810599 1102668 *regulation* of [TrkA/NGF receptor] expression in developing sensory neurons . Regulation NKX2-1 TNF 10499522 647812 *regulation* of [thyroid transcription factor-1] and Pax-8 in rat thyroid FRTL-5 cells . Regulation NKX2-1 TNF 10499522 647817 The suppressive *effect* of on [TTF-1-DNA] complex formation is , in part , caused by suppression of TTF-1 gene transcription by TNF-alpha . Regulation NKX2-1 TNF 21784970 2484592 In this study , we identified functionally important transcription factor binding sites in the TTF-1 proximal promoter and studied *regulation* of [TTF-1] expression . Regulation NLRP3 IL1B 16407888 1527489 Furthermore , we show that Toll-like receptors and [cryopyrin] *control* the secretion of and IL-18 through different intracellular pathways . Regulation NLRP3 IL1B 19454352 2084486 The known fungal pattern recognition receptors TLR2 and Dectin-1 regulate IL-1beta gene transcription , whereas the [NLRP3] containing proinflammatory multiprotein complex , the NLRP3 inflammasome , *controls* caspase-1 mediated cleavage of . Regulation NLRP3 TLR7 22569257 2596940 induced NF-?B activation *regulates* [NLRP3] expression in murine macrophages . Regulation NLRP3 TLR7 22569257 2596960 Therefore , out results delineated the molecular mechanisms involved in induced transcriptional *regulation* of [NLRP3] . Regulation NLRP3 TNF 23687262 2932193 This study found evidence of modulation of the NLRP3-inflammasome in patients with RA prior to receiving infliximab and some evidence of association for SNPs at [NLRP3] and CARD8 loci with RA susceptibility and *response* to . Regulation NM IL1B 11114238 757776 The *effect* of recombinant ( rHIL-1beta ) and interleukin-8 ( rHIL-8 ) on bovine [neutrophil migration] was investigated using this system . Regulation NM MAP2K6 9405284 480186 This demonstrates that , while neither nor ERK kinases are *involved* in the activation of respiratory burst or [neutrophil migration] , inhibition of PAF release suggests a potential role in the activation of cytosolic phospholipase A2 . Regulation NM PLAU 16425131 1515699 receptor *plays* a role in [neutrophil migration] during lipopolysaccharide induced peritoneal inflammation but not during Escherichia coli induced peritonitis . Regulation NM TNF 11202062 785436 We examined the *effect* of SP , VIP and the novel sensory neuropeptide secretoneurin ( SN ) , as well as of interleukin (IL)-8 , IL-6 , IL-1 beta , transforming growth factor (TGF)-beta , and , all associated with acute lung injury , on human [neutrophil migration] across a 5-mu pore polycarbonate filter system covered by human lung fibroblast monolayers . Regulation NM TNF 11453371 836972 The *effect* of inhibitors in Clostridium difficile toxin induced paw oedema and [neutrophil migration] . Regulation NM TNF 18716928 1951044 Unlike the response to LPS , [neutrophil migration] in *response* to was not altered by the presence of lung epithelial cells , except at a low concentration of TNF-alpha upon alveolar directional exposure of the endothelium , i.e. , from the epithelial side of the bilayer . Regulation NM TNF 7722453 301833 Fibrin regulates [neutrophil migration] in *response* to interleukin 8 , leukotriene B4 , , and formyl-methionyl-leucyl-phenylalanine . Regulation NME1 EFNB1 22718351 2691561 These results indicate a novel function of [Nm23-H1] to control CIL , and its negative *regulation* by . Regulation NMU CTGF 22761259 2634507 Moreover , [NMU] , whose expression is induced in *response* to , partially mimics the effects of CTGF on actomyosin organization in TM cells , and decreases AH outflow facility , revealing a potentially important role for this neuropeptide in the homeostasis of AH drainage . Regulation NNMT IL6 22661188 2610856 Interestingly , exercise induced activation of [NNMT] in the liver *involves* , while the rise in MNA concentration in plasma was partially IL-6 independent . Regulation NOD2 TNF 12671897 1076278 and IFN-gamma *regulate* the expression of the [NOD2] ( CARD15 ) gene in human intestinal epithelial cells . Regulation NOD2 TNF 12835899 1107869 [NOD2] mRNA levels increased greater than two-fold in a monocyte cell line in *response* to lipopolysaccharide , lipoteichoic acid , interferon-g and . Regulation NOD2 TNF 16164210 1456244 Osteoblasts express [NOD2] , an intracellular sensor for MDP , in *response* to LPS , IL-1 and . Regulation NOD2 TNF 16465024 1522955 Osteoblasts express [nucleotide oligomerization domain (NOD)2] , an intracellular sensor for MDP , in *response* to LPS , IL-1 and . Regulation NOS1 ARSA 14705149 1196266 The present study was designed to evaluate the *effect* of on oxidative stress and the activity of [nitric oxide synthase (NOS)] in an in vitro model of hypoxia in rat brain slices . Regulation NOS1 ARSA 16105666 1454183 We examined in HT-29 human colon adenocarcinoma cells the *effect* of on the inducible form of [nitric oxide synthase] ( NOS2 ) , an enzyme implicated in colon carcinogenesis . Regulation NOS1 BLVRA 25206501 2886919 We hypothesize that dependent inducible [nitric oxide synthase] *regulation* strongly contributes to the cognitive improvement observed following atorvastatin treatment . Regulation NOS1 CAPN8 10835326 699180 *Role* of in hypoxic inhibition of [nitric oxide synthase] activity in pulmonary endothelial cells . Regulation NOS1 EDN2 10770961 686097 Dysfunctional renal [nitric oxide synthase] as a determinant of salt-sensitive hypertension : mechanisms of renal artery endothelial dysfunction and *role* of for vascular hypertrophy and Glomerulosclerosis . Regulation NOS1 GLP1R 18633100 1966642 Moreover , hypothalamic [nitric oxide synthase] activity and the concentration of reactive oxygen species ( ROS ) were also reduced in a *dependent* manner , whereas the glutathione antioxidant capacity was increased . Regulation NOS1 IL1B 10967106 751787 These results demonstrate that is *involved* in inducible [nitric oxide synthase] gene expression and induction of apoptosis in mouse beta cells but does not contribute to impaired glucose stimulated insulin secretion . Regulation NOS1 IL1B 11222532 787694 The purpose of these studies was to investigate the *role* of interferon-gamma (IFN-gamma) , tumor necrosis factor-alpha (TNF-alpha) , , and transforming growth factor-beta ( TGF-beta ) in the regulation of inducible [nitric oxide synthase] ( NOS2 ) activity in rabbit corneal cells . Regulation NOS1 IL1B 12154205 971722 To compare the time- and concentration dependent *effects* of tumour necrosis factor alpha (TNF-alpha) and on the induction of [nitric oxide synthase (NOS)] , the production of nitric oxide ( NO ) and the expression of aggrecan and hyaluronan ( HA ) in chondrocytes . Regulation NOS1 IL1B 7528993 284164 *Regulation* of inducible [nitric oxide synthase] gene by in rat vascular endothelial cells . Regulation NOS1 IL1B 7679081 211179 Moreover , the stimulatory *effects* of recombinant on [NOS] mRNA expression are prevented by co-incubation with an inhibitor of gene transcription ( actinomycin D ) or an inhibitor of protein synthesis ( cycloheximide ) . Regulation NOS1 IL1B 8613229 353426 Mechanisms of *regulation* of [nitric oxide synthase] in cardiac myocytes . Regulation NOS1 IL1B 9259476 448699 The dominant *role* of exogenous or endogenous on expression and activity of inducible [nitric oxide synthase] in rat microvascular brain endothelial cells . Regulation NOS1 IL1B 9931117 589013 *regulation* of inducible [nitric oxide synthase] and cyclooxygenase-2 involves the p42/44 and p38 MAPK signaling pathways in cardiac myocytes . Regulation NOS1 S100B 8576219 350272 Furthermore , the specificity of the *effects* of on activation of [NOS] was demonstrated by the inability of S100 alpha and calmodulin to induce an increase in nitrite levels . Regulation NOS1 SPHK1 16857953 1600469 *dependent* activation of endothelial [nitric oxide synthase] by angiotensin II . Regulation NOS1 TLR7 10426995 632988 Several lipoproteins stimulated *dependent* transcription of inducible [nitric oxide synthase] and the production of nitric oxide , a powerful microbicidal pathway . Regulation NOS1 TLR7 15994412 1447053 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for tumor necrosis factor ( TNF-alpha ) , interleukin 6 , [nitric oxide synthase-II] ( iNOS ) , and NADPH oxidase 2 (Nox2) . Regulation NOS1 TLR7 21876038 2486747 regulation of SPSB1 *controls* inducible [nitric oxide synthase] induction . Regulation NOS1 TNF 10713108 675823 Beta-amyloid stimulation of inducible [nitric-oxide synthase] in astrocytes is interleukin-1beta- and *dependent* , and involves a TNFalpha receptor associated factor- and NFkappaB inducing kinase dependent signaling mechanism . Regulation NOS1 TNF 10788433 688671 Divergence in *regulation* of [nitric-oxide synthase] and its cofactor tetrahydrobiopterin by . Regulation NOS1 TNF 11031095 740157 and ( ii ) TNF-alpha initiated apoptosis may be mediated in part by NO as produced by a [NOS] expressed in *response* to . Regulation NOS1 TNF 11160388 781726 beta-Amyloid stimulation of microglia and monocytes results in *dependent* expression of inducible [nitric oxide synthase] and neuronal apoptosis . Regulation NOS1 TNF 12154205 971721 To compare the time- and concentration dependent *effects* of and interleukin 1beta (IL-1beta) on the induction of [nitric oxide synthase (NOS)] , the production of nitric oxide ( NO ) and the expression of aggrecan and hyaluronan ( HA ) in chondrocytes . Regulation NOS1 TNF 16827641 1586618 The *role* of in mediating pathophysiological activity of inducible [nitric oxide synthase] during transplant vasculopathy remains contentious . Regulation NOS1 TNF 19353522 2064855 C/EBPbeta knockdown also inhibited the synergistic expression of CXCL1 , inducible [nitric oxide synthase] , and CCL5 in *response* to concomitant IFNgamma and . Regulation NOS1 TNF 19802525 2209144 We evaluated the *role* of the pro-inflammatory cytokine on [nitric oxide synthase (NOS)] expression in indomethacin induced jejunoileitis in rats . Regulation NOS1 TNF 7513301 253698 In this study , we determine whether produced by activated bone marrow derived macrophages ( BMM ) is *involved* in the induction of the inducible NO synthase gene ( [mac-NOS] ) for NO-dependent amebicidal activity . Regulation NOS1 TNF 7539338 307016 Using previously published data , we developed a pharmacokinetic-pharmacodynamic model that relates the production of TNF in response to administration of FAA , the enhancement of [NOS] activity in *response* to , and the elevation of plasma nitrate in response to NO production . Regulation NOS1 TNF 7693276 231233 1. This study investigates the *role* of in the induction of [nitric oxide synthase (NOS)] by bacterial endotoxin ( lipopolysaccharide ; Regulation NOS1 TNF 8779862 379926 *Roles* of IL-1 and in endotoxin induced activation of [nitric oxide synthase] in cultured rat brain cells . Regulation NOS1 TNF 8779862 379935 To determine whether LPS induction of NOS in brain cells is mediated by IL-1 or TNF-alpha , acting alone or in concert , the *effects* of IL-1-receptor antagonist (IL-1Ra) and of receptor ( TNFsRp55 ) , presented individually and in combination , on LPS induced [NOS] activity were tested . Regulation NOS1 TNF 9834372 479676 *regulates* inducible [nitric oxide synthase] gene expression in the portal hypertensive gastric mucosa of the rat . Regulation NOS1 TNF 9875639 557206 The *effect* of and interferon-gamma on L-arginine transport , mRNA expression of cationic amino acid transporter and inducible [nitric oxide synthase] , and nitric oxide production of stellate cells was assessed . Regulation NOS1 TNF 9875639 557221 In transformed hepatic stellate cells , and interferon-gamma have a crucial role in nitric oxide production , and extracellular L-arginine transport and inducible [nitric oxide synthase] expression are *regulated* in a differential cytokine-specific manner . Regulation NOS2 ARSA 10493988 646915 Given the lack of conserved regulation of iNOS expression in rodent and human systems , we sought to test the *effect* of <5-ASA> on the expression of human [iNOS] in cultured enterocytes . Regulation NOS2 ARSA 16105666 1454184 We examined in HT-29 human colon adenocarcinoma cells the *effect* of on the inducible form of [nitric oxide synthase] ( NOS2 ) , an enzyme implicated in colon carcinogenesis . Regulation NOS2 BLVRA 25206501 2886920 We hypothesize that dependent inducible [nitric oxide synthase] *regulation* strongly contributes to the cognitive improvement observed following atorvastatin treatment . Regulation NOS2 CAPN8 10835326 699194 *Role* of in hypoxic inhibition of [nitric oxide synthase] activity in pulmonary endothelial cells . Regulation NOS2 EDN2 10770961 686100 Dysfunctional renal [nitric oxide synthase] as a determinant of salt-sensitive hypertension : mechanisms of renal artery endothelial dysfunction and *role* of for vascular hypertrophy and Glomerulosclerosis . Regulation NOS2 EDN2 18973526 2086089 The *roles* of the receptors A and B ( ET ( A ) and ET ( B ) ) in CsA enhanced expression of PCNA and [iNOS] were examined in cultured human gingival fibroblasts pretreated with receptor antagonists , by immunocytochemistry and RT-PCR , respectively . Regulation NOS2 EDN2 9585124 504467 *Regulation* of [inducible NO synthase] expression by in primary cultured glial cells . Regulation NOS2 EPHB2 16527246 1536143 These results suggest that the transcription factor NF-kappaB is involved in mediated [iNOS] *regulation* and that activation of the Ras/ERK pathway contributes to the induction of iNOS expression in RAW264.7 cells in response to LPS . Regulation NOS2 EPHB2 23143065 2717920 OPTmecAMP inactivated Raf1/MEK/ERK signaling , but had no *effect* on [iNOS] expression . Regulation NOS2 GLP1R 18633100 1966643 Moreover , hypothalamic [nitric oxide synthase] activity and the concentration of reactive oxygen species ( ROS ) were also reduced in a *dependent* manner , whereas the glutathione antioxidant capacity was increased . Regulation NOS2 HBEGF 16034135 1436442 Small interfering RNA of PI3K also reversed the inhibitory *effect* of on [iNOS] expression . Regulation NOS2 HBEGF 23393916 2713224 These results suggest that *regulates* [iNOS] expression and NO production in adipocytes through the modulating activation of NF-kappaB and may have a potential clinical application within protocols designed for treating metabolic syndrome . Regulation NOS2 IGFBP1 7499972 336127 Taken together , these data indicate that activities are *involved* in the regulation of [iNOS] gene expression in murine macrophages . Regulation NOS2 IL1B 10533051 562390 We have determined the role of PAF in the *regulation* of cyclooxygenase-2 (COX-2) and [inducible nitric oxide synthase (iNOS)] genes by in rat primary hippocampal cultures . Regulation NOS2 IL1B 10642306 660792 We have previously shown that the *regulation* by of [inducible nitric oxide synthase (iNOS)] involves phospholipase A(2) ( PLA(2) ) metabolites in neonatal ventricular myocytes . Regulation NOS2 IL1B 10642306 660793 Based on studies in which ONO-RS-082 is used to inhibit secretory PLA(2) and methyl arachidonyl fluorophosphonate is used to inhibit cytosolic PLA(2) , our data suggest that a secretory PLA(2) metabolite was involved in the *regulation* by of [iNOS] . Regulation NOS2 IL1B 10924055 718156 We conclude that 1 ) the upregulation of tissue , via a signaling pathway involving a Src family kinase , *plays* a key role in rat vascular [iNOS] induction and 2 ) non-Src tyrosine kinases play roles downstream from IL-1beta for iNOS induction . Regulation NOS2 IL1B 10967106 751788 These results demonstrate that is *involved* in inducible [nitric oxide synthase] gene expression and induction of apoptosis in mouse beta cells but does not contribute to impaired glucose stimulated insulin secretion . Regulation NOS2 IL1B 11222532 787699 The purpose of these studies was to investigate the *role* of interferon-gamma (IFN-gamma) , tumor necrosis factor-alpha (TNF-alpha) , , and transforming growth factor-beta ( TGF-beta ) in the regulation of inducible [nitric oxide synthase] ( NOS2 ) activity in rabbit corneal cells . Regulation NOS2 IL1B 11474579 841774 Transcriptional *regulation* of the human [iNOS] gene by in endothelial cells . Regulation NOS2 IL1B 11474579 841775 We examined the transcriptional *regulation* of the human [iNOS] gene by in rat pulmonary microvascular endothelial cells ( PVEC ) by transient cotransfections of different iNOS-promoter constructs and cDNA of different transcription factors and regulatory proteins . Regulation NOS2 IL1B 11474579 841784 Both NF-kappaB and C/EBP pathways are important for the transcriptional *regulation* of the human [iNOS] gene by in PVEC . Regulation NOS2 IL1B 12225970 987942 Mutation of the E-box sequence augmented the [iNOS] *response* to in transiently transfected mesangial cells . Regulation NOS2 IL1B 12237341 989190 Because ICE activity is essential for the endogenous synthesis of active IL-1beta , ICE overexpression represents the key signal in the AmB induced and mediated *effects* on [iNOS] activity . Regulation NOS2 IL1B 12543127 1050786 While these observations suggest that is *involved* in mediating LPS induced [iNOS] expression and activity , the differential response of GB1 and K-strain macrophages in terms of LPS induced iNOS expression and activity is unlikely to be modulated by IL-1beta . Regulation NOS2 IL1B 12823994 1104348 Lacrimal gland acinar cells are able to produce [iNOS] in *response* to the pro-inflammatory cytokine . Regulation NOS2 IL1B 17146391 1653975 Pharmacologic inhibitors such as PD98059 ( an extracellular regulated protein kinase [ ERKs ] inhibitor ) , SB203580 ( a p38 mitogen activated protein kinase [ MAPK ] inhibitor ) , SP600125 ( a c-Jun N-terminal kinases [ JNKs ] ) inhibitor ) , and LY294002 ( an inhibitor of phosphoinositide 3-kinase [ PI3 K ] ) were used to see the role of JNKs , ERKs , p38 MAPK , or PI3 K signaling pathway ( s ) in [iNOS] expression in *response* to in HEI-OC1 cells . Regulation NOS2 IL1B 17512943 1751191 In wild-type fibroblasts , was only a weak inducer of iNOS and of NO accumulation and hypoxia alone had no significant *effect* on [iNOS] activation . Regulation NOS2 IL1B 18300858 1873460 However , the high concentration of D-glucose did increase [iNOS] expression in *response* to low concentrations of IL-1beta ( 2.5 and 5 ng/ml ) , as well as the induced activation of both ERK 1/2 and NF-kappaB . Regulation NOS2 IL1B 18313411 1897486 CO was found to increase p38 phosphorylation and p38 inhibition using SB203580 increased [iNOS] protein levels in *response* to . Regulation NOS2 IL1B 20717505 2306734 AF pellet resulted in dose dependent [iNOS] and COX-2 expression in *response* to , stimulation , demonstrating that 1 ng/ml for 24 hours yielded a maximal response . Regulation NOS2 IL1B 20717505 2306738 AF pellet in NCCM significantly decreased the expression of [iNOS] and COX-2 in *response* to 1ng/ml , stimulation at 24 hours ( p < 0.05 ) . Regulation NOS2 IL1B 7488131 332115 Here we report that cyclosporin A (CsA) a potent immunosuppressive drug , inhibits *dependent* [iNOS] expression in renal mesangial cells . Regulation NOS2 IL1B 7488131 332117 Furthermore , by electrophoretic mobility shift analysis we demonstrate reduced DNA binding of the nuclear factor NF kappa B , an essential component of the *dependent* upregulation of [iNOS] gene transcription . Regulation NOS2 IL1B 7528007 280916 We examined whether dexamethasone differentially affects [iNOS] induction in *response* to and a membrane-permeable cAMP analogue , N6,O-2'-dibutyryladenosine 3',5'-phosphate ( Bt2cAMP ) . Regulation NOS2 IL1B 7528993 284165 *Regulation* of inducible [nitric oxide synthase] gene by in rat vascular endothelial cells . Regulation NOS2 IL1B 7534733 287762 [iNOS] mRNA degradation is rapid and it is not *affected* by . Regulation NOS2 IL1B 7588294 333833 The present study was performed to investigate the *effects* of , tumor necrosis factor-alpha (TNF-alpha) , and interferon-gamma (IFN-gamma) on the expression of [inducible NO-synthase (iNOS)] and to measure high-output production of NO by primary rat osteoblasts and osteoblastic cell lines ROS 17/2.8 , MC3T3-E1 and MG-63 . Regulation NOS2 IL1B 8613229 353427 Mechanisms of *regulation* of [nitric oxide synthase] in cardiac myocytes . Regulation NOS2 IL1B 8662883 367478 Inhibition of de novo BH4 synthesis with 2,4-diamino-6-hydroxypyrimidine ( DAHP ) significantly attenuated [iNOS] activity as well as mRNA and protein expression in *response* to plus tumor necrosis factor alpha ( IL-1beta/TNF-alpha ) . Regulation NOS2 IL1B 8760147 378032 Transcriptional *regulation* of [iNOS] by in cultured rat pulmonary artery smooth muscle cells . Regulation NOS2 IL1B 8760147 378033 Transcriptional *regulation* of [iNOS] by in cultured rat pulmonary artery smooth muscle cells . Regulation NOS2 IL1B 8760147 378035 Accordingly , we sought to determine a *role* for in stimulating [iNOS] transcription in cultured rat pulmonary artery smooth muscle cells ( RPASMC ) . Regulation NOS2 IL1B 8879343 390743 Thus , *controls* [iNOS] gene expression at the transcriptional level , and an intermediate labile protein , whose synthesis is inhibited by cycloheximide , is required for IL-1 beta stimulated induction of iNOS mRNA transcription in WKY cells but not in SHR . Regulation NOS2 IL1B 8982730 403909 However , whether endogenously produced NO can fulfil this function critically depends on a balance between a yet to be defined protective mechanism and [inducible NO synthase] expression in mesangial cells in *response* to and eventually other inflammatory cytokines . Regulation NOS2 IL1B 9153221 431252 These studies show that the T-lymphocyte cytokine , IFN-gamma , increases the sensitivity of rat islets to the *effects* of on [iNOS] expression and nitrite production by 10-fold , in part , through the stabilization of iNOS mRNA . Regulation NOS2 IL1B 9231726 444927 The inhibitory effect of ET on TNF-alpha/IL-1beta stimulated iNOS expression appears to be mediated by ET ( B ) receptors , because ( 1 ) both ET-1 and ET-3 inhibited the *effects* of on [iNOS] expression and nitrite accumulation , ( 2 ) a selective ET ( B ) receptor agonist , Suc- [ Glu ( 9 ) , Ala ( 11,15 ) ] -ET-1 ( 8-21 ) ( IRL1620 ) , decreased the effects of TNF-alpha/IL-1beta , and ( 3 ) a selective ET ( B ) receptor antagonist , N-cis-2,6-dimethylpiperidinocarbonyl-L-gamma-methylleucyl-D- 1-methoxycarbonyltryptophanyl-D-norleucine , abolished the inhibitory effects of ETs and IRL1620 . Regulation NOS2 IL1B 9259476 448700 The dominant *role* of exogenous or endogenous on expression and activity of inducible [nitric oxide synthase] in rat microvascular brain endothelial cells . Regulation NOS2 IL1B 9259476 448705 Furthermore , our results indicate a decisive *role* of in [iNOS] expression and NO generation . Regulation NOS2 IL1B 9315292 455768 Tumor necrosis factor-alpha and are *involved* in the induction of [iNOS] gene as well as the immune system . Regulation NOS2 IL1B 9590244 504777 Abs against cyclic AMP-responsive element binding protein , C/EBPbeta , and C/EBPdelta were able to partially supershift single complexes , suggesting the participation of these transcription factors in the *regulation* of [iNOS] gene expression by cAMP and . Regulation NOS2 IL1B 9696008 524412 IL-1beta-receptor antagonist (IL-1ra) , which interferes with the interaction of IL-1beta with target cells , also abolished the inhibitory *effects* of on hepatocyte DNA synthesis as well as IL-1beta induced [iNOS] gene expression . Regulation NOS2 IL1B 9931117 589014 *regulation* of inducible [nitric oxide synthase] and cyclooxygenase-2 involves the p42/44 and p38 MAPK signaling pathways in cardiac myocytes . Regulation NOS2 MAP2K6 16806046 1625168 In contrast , PD98059 , a specific inhibitor of that acts immediately upstream of classic MAP kinase , had no *effect* on the induction of [iNOS] , NO or DNA fragmentation in the cells . Regulation NOS2 PTGER2 17091492 1667558 Pharmacological and RNA interference approaches further indicated the *involvement* of the receptor in PGE ( 2 ) -induced [iNOS] upregulation in T/I treated astrocytes . Regulation NOS2 SPHK1 11815603 922502 In contrast , enforced expression of had no *effect* on [iNOS] expression or NO formation . Regulation NOS2 SPHK1 16857953 1600471 *dependent* activation of endothelial [nitric oxide synthase] by angiotensin II . Regulation NOS2 SPHK1 17512943 1751186 To determine whether *regulates* cell proliferation and the proinflammatory protein [inducible nitric oxide synthase (iNOS)] , we exposed cultured cardiac fibroblasts to the cytokine interleukin-1beta (IL-1beta) and/or hypoxia . Regulation NOS2 STK39 18621907 1966391 Together , the data demonstrate a central *role* of in the upregulation of both arginase II and [iNOS] in bPAEC in response to L/T treatment . Regulation NOS2 TLR7 10426995 632998 Several lipoproteins stimulated *dependent* transcription of inducible [nitric oxide synthase] and the production of nitric oxide , a powerful microbicidal pathway . Regulation NOS2 TLR7 15994412 1447063 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for tumor necrosis factor ( TNF-alpha ) , interleukin 6 , [nitric oxide synthase-II] ( iNOS ) , and NADPH oxidase 2 (Nox2) . Regulation NOS2 TLR7 21876038 2486758 regulation of SPSB1 *controls* inducible [nitric oxide synthase] induction . Regulation NOS2 TNF 10417671 631637 Treatment with anti-TNF-alpha mAb did not affect the expression of IFN-gamma in the LPC but inhibited expression of iNOS in the infected mice , indicating the *role* of in the induction of [iNOS] . Regulation NOS2 TNF 10516205 652289 The *effects* of on [inducible NO synthase (iNOS)] were not characterized . Regulation NOS2 TNF 10664866 578422 The authors focus on some of the molecular events involved in and IFN-gamma signal transduction and the *regulation* of [iNOS] and IGF-I genes in macrophages . Regulation NOS2 TNF 10705297 673075 Therefore , in the present study , we investigated the *role* of endogenous IFN-gamma , and IL-10 in the regulation of LPS induced tissue [iNOS] expression in the major organs . Regulation NOS2 TNF 10705297 673081 Immunohistochemical staining for iNOS and determination of iNOS activity indicated that iNOS expression was mainly upregulated in the small intestine , lung and heart , and that IFN-gamma , as well as IL-10 are *involved* in the regulation of [iNOS] expression and enzyme activity . Regulation NOS2 TNF 10705297 673083 Whereas blocking either IFN-gamma or did not *affect* [iNOS] expression , iNOS enzymatic activity seems to be inhibited . Regulation NOS2 TNF 10713108 675824 Beta-amyloid stimulation of inducible [nitric-oxide synthase] in astrocytes is interleukin-1beta- and *dependent* , and involves a TNFalpha receptor associated factor- and NFkappaB inducing kinase dependent signaling mechanism . Regulation NOS2 TNF 10729362 678234 We used the reverse transcriptase-polymerase chain reaction ( RT-PCR ) to identify the subtypes of NO synthase that were expressed in the ST2 cells and we detected the expression of an [inducible NO synthase] gene in *response* to . Regulation NOS2 TNF 10788433 688672 Divergence in *regulation* of [nitric-oxide synthase] and its cofactor tetrahydrobiopterin by . Regulation NOS2 TNF 10788433 688674 Indeed , we found that bacterial sphingomyelinase , which hydrolyzes sphingomyelin and increases endogenous ceramide , or the cell permeable ceramide analogue , C ( 2 ) -ceramide , but not C ( 2 ) -dihydroceramide ( N-acetylsphinganine ) , significantly mimicked the *effects* of on NO production and [iNOS] expression and activity in C6 cells . Regulation NOS2 TNF 11095498 755269 In this study we determined the *effect* of on [iNOS] in NGF-responsive pheochromocytoma ( PC12 ) cells . Regulation NOS2 TNF 11160388 781727 beta-Amyloid stimulation of microglia and monocytes results in *dependent* expression of inducible [nitric oxide synthase] and neuronal apoptosis . Regulation NOS2 TNF 11192310 779550 Comparison of *effect* on the expression of [iNOS] in macrophage and cardiac myocytes . Regulation NOS2 TNF 11521163 852421 However , incubation with HCL-31D ( 1 approximately 50 microM ) for 24 h caused significant attenuation of nitrite and formation as well as iNOS mRNA induction in a dose dependent manner but no *effect* on [iNOS] activity in RASMC . Regulation NOS2 TNF 11535575 854728 *plays* an important role in induction of [iNOS] . Regulation NOS2 TNF 12631094 1067584 A *role* of on enhanced [iNOS] was suggested by the finding of increased urine levels in obstructed pelvis . Regulation NOS2 TNF 12675973 1076741 These data suggest that after SCI , apoptosis induced by TNF-alpha may be mediated in part by NO via upregulation of [iNOS] , induced in *response* to . Regulation NOS2 TNF 12832676 1105792 L-NAME and the eNOS inhibitor N ( 5 ) - ( 1-iminoethyl ) -ornithine ( L-NIO ) enhanced O ( 2 ) ( *- ) formation from PA ( with endothelium ) in *response* to IL-1alpha and but had no effect on LPS mediated O ( 2 ) ( *- ) formation , whereas L-NAME and the [iNOS] inhibitor L-N ( 6 ) - ( 1-iminoethyl ) -lysine-HCl ( L-NIL ) enhanced O ( 2 ) ( *- ) formation only in response to LPS . Regulation NOS2 TNF 16055364 1488947 Although TNF-alpha is one of the iNOS-inducible factors , the [iNOS] up-regulation was not *regulated* by . Regulation NOS2 TNF 16827641 1586619 The *role* of in mediating pathophysiological activity of inducible [nitric oxide synthase] during transplant vasculopathy remains contentious . Regulation NOS2 TNF 17475277 1744079 Although STAT1 activation and expression did not change significantly in TNF-alpha/IFN-gamma cotreated cells compared with cells treated with IFN-gamma alone , the absence of STAT1 or interferon regulatory factor 1 (IRF-1) in genetic knockout mice strongly abrogated the observed *effects* of on [iNOS/NO] induction , ROS production , loss of mitochondrial transmembrane potential ( DeltaPsim ) , and apoptosis compared with STAT1 ( +/+ ) and IRF-1 ( +/+ ) mice . Regulation NOS2 TNF 17475277 1744082 Additionally , the synergistic *effects* of on [iNOS/NO] induction , ROS production , and apoptosis were significantly inhibited by overexpression of dominant negative STAT1 in contrast to overexpression of wild-type STAT1 . Regulation NOS2 TNF 18369347 1912826 The *effects* of on [inducible NOS (iNOS)] protein expression in adipocytes were also measured by western blotting . Regulation NOS2 TNF 18606162 1947247 However , blockade of TNF-alpha action and COX-2 activity with anti-TNF-alpha antibodies and indomethacin , respectively , revealed that modulation of and COX-2 was not *involved* in adenosine mediated [iNOS] suppression . Regulation NOS2 TNF 19353522 2064857 C/EBPbeta knockdown also inhibited the synergistic expression of CXCL1 , inducible [nitric oxide synthase] , and CCL5 in *response* to concomitant IFNgamma and . Regulation NOS2 TNF 22065579 2534133 Phorbol ester- and *dependent* activation of the ERK regulated transcription factors Elk1 and NF-?B and expression of the [iNOS] gene were suppressed by hBVR siRNA ; Regulation NOS2 TNF 24039983 2842421 Paraquat poisoning induces *dependent* [iNOS/NO] mediated hyporesponsiveness of the aorta to vasoconstrictors in rats . Regulation NOS2 TNF 7513301 253699 In this study , we determine whether produced by activated bone marrow derived macrophages ( BMM ) is *involved* in the induction of the [inducible NO synthase] gene ( mac-NOS ) for NO-dependent amebicidal activity . Regulation NOS2 TNF 7513694 253782 The *role* of endogenous and interferon-beta (IFN-beta) in lipopolysaccharide (LPS) induced activation of the [inducible nitric-oxide synthase (i-NOS)] gene was investigated . Regulation NOS2 TNF 7588294 333831 The present study was performed to investigate the *effects* of interleukin-1 beta (IL-1 beta) , , and interferon-gamma (IFN-gamma) on the expression of [inducible NO-synthase (iNOS)] and to measure high-output production of NO by primary rat osteoblasts and osteoblastic cell lines ROS 17/2.8 , MC3T3-E1 and MG-63 . Regulation NOS2 TNF 8680718 343250 In marked contrast the presence of had no *effect* on IL-1 alpha/IFN-gamma induced [iNOS] mRNA expression by HT-29 cells . Regulation NOS2 TNF 8779862 379928 *Roles* of IL-1 and in endotoxin induced activation of [nitric oxide synthase] in cultured rat brain cells . Regulation NOS2 TNF 9231726 444926 The inhibitory effect of ET on TNF-alpha/IL-1beta stimulated iNOS expression appears to be mediated by ET ( B ) receptors , because ( 1 ) both ET-1 and ET-3 inhibited the *effects* of on [iNOS] expression and nitrite accumulation , ( 2 ) a selective ET ( B ) receptor agonist , Suc- [ Glu ( 9 ) , Ala ( 11,15 ) ] -ET-1 ( 8-21 ) ( IRL1620 ) , decreased the effects of TNF-alpha/IL-1beta , and ( 3 ) a selective ET ( B ) receptor antagonist , N-cis-2,6-dimethylpiperidinocarbonyl-L-gamma-methylleucyl-D- 1-methoxycarbonyltryptophanyl-D-norleucine , abolished the inhibitory effects of ETs and IRL1620 . Regulation NOS2 TNF 9315292 455767 and interleukin-1 beta are *involved* in the induction of [iNOS] gene as well as the immune system . Regulation NOS2 TNF 9834372 479677 *regulates* inducible [nitric oxide synthase] gene expression in the portal hypertensive gastric mucosa of the rat . Regulation NOS2 TNF 9875639 557208 The *effect* of and interferon-gamma on L-arginine transport , mRNA expression of cationic amino acid transporter and inducible [nitric oxide synthase] , and nitric oxide production of stellate cells was assessed . Regulation NOS2 TNF 9875639 557223 In transformed hepatic stellate cells , and interferon-gamma have a crucial role in nitric oxide production , and extracellular L-arginine transport and inducible [nitric oxide synthase] expression are *regulated* in a differential cytokine-specific manner . Regulation NOS3 ANGPT1 12759249 1091073 In summary , our results demonstrate for the first time that endothelial derived NO is required for Ang1 induced angiogenesis , and that the PI3-kinase signaling mediates the activation of [eNOS] and NO release in *response* to . Regulation NOS3 ARSA 16105666 1454185 We examined in HT-29 human colon adenocarcinoma cells the *effect* of on the inducible form of [nitric oxide synthase] ( NOS2 ) , an enzyme implicated in colon carcinogenesis . Regulation NOS3 BLVRA 25206501 2886921 We hypothesize that dependent inducible [nitric oxide synthase] *regulation* strongly contributes to the cognitive improvement observed following atorvastatin treatment . Regulation NOS3 CAPN8 10835326 699208 *Role* of in hypoxic inhibition of [nitric oxide synthase] activity in pulmonary endothelial cells . Regulation NOS3 CAPN8 15793253 1386961 Immunoprecipitation studies revealed *dependent* loss of association between [eNOS] and the regulatory protein heat shock protein 90 . Regulation NOS3 CAPN8 16100081 1466477 In this study , we evaluated the *role* of in CSE induced decrease in [eNOS] gene expression . Regulation NOS3 EDN2 10770961 686103 Dysfunctional renal [nitric oxide synthase] as a determinant of salt-sensitive hypertension : mechanisms of renal artery endothelial dysfunction and *role* of for vascular hypertrophy and Glomerulosclerosis . Regulation NOS3 EDN2 12623978 1066536 We asked whether might *play* a role in the control of basal or osmotically regulated NPR-A or [eNOS] gene expression in these cells . Regulation NOS3 EPHB2 14586499 1165268 Our results show that C-peptide increases NO production by increasing eNOS protein contents through *dependent* up-regulation of [eNOS] gene transcription . Regulation NOS3 EPHB2 16164642 1456362 and VEGF stimulated eNOS phosphorylation on Ser1177 was prevented by PD098059 , an upstream inhibitor of ERK , demonstrating that was *involved* in VEGF regulation of [eNOS] . Regulation NOS3 EPHB2 17098545 1644693 Pressure modulates endothelial cell effects on SMC growth by increasing [eNOS] in an *dependent* and PKC dependent manner . Regulation NOS3 GLP1R 18633100 1966644 Moreover , hypothalamic [nitric oxide synthase] activity and the concentration of reactive oxygen species ( ROS ) were also reduced in a *dependent* manner , whereas the glutathione antioxidant capacity was increased . Regulation NOS3 HBEGF 18925469 1994484 However , the *role* of in regulation of [eNOS] has not yet been investigated . Regulation NOS3 IL1B 10967106 751789 These results demonstrate that is *involved* in inducible [nitric oxide synthase] gene expression and induction of apoptosis in mouse beta cells but does not contribute to impaired glucose stimulated insulin secretion . Regulation NOS3 IL1B 11222532 787704 The purpose of these studies was to investigate the *role* of interferon-gamma (IFN-gamma) , tumor necrosis factor-alpha (TNF-alpha) , , and transforming growth factor-beta ( TGF-beta ) in the regulation of inducible [nitric oxide synthase] ( NOS2 ) activity in rabbit corneal cells . Regulation NOS3 IL1B 15135362 1245906 Finally , did not *affect* [eNOS] expression but up-regulated iNOS mRNA and protein levels . Regulation NOS3 IL1B 16497991 1548960 These results indicate that and BPS antagonistically *regulates* the [eNOS] expression through the activation of p38 and PKA , respectively . Regulation NOS3 IL1B 7528993 284166 *Regulation* of inducible [nitric oxide synthase] gene by in rat vascular endothelial cells . Regulation NOS3 IL1B 8613229 353428 Mechanisms of *regulation* of [nitric oxide synthase] in cardiac myocytes . Regulation NOS3 IL1B 9259476 448701 The dominant *role* of exogenous or endogenous on expression and activity of inducible [nitric oxide synthase] in rat microvascular brain endothelial cells . Regulation NOS3 IL1B 9931117 589015 *regulation* of inducible [nitric oxide synthase] and cyclooxygenase-2 involves the p42/44 and p38 MAPK signaling pathways in cardiac myocytes . Regulation NOS3 MAP2K6 16102116 1444429 P < 0.05 ) , whereas HGF induced phosphorylation of the [eNOS] was not *affected* by inhibition . Regulation NOS3 PECAM1 16118242 1454351 *Role* of in the shear-stress induced activation of Akt and the [endothelial nitric oxide synthase (eNOS)] in endothelial cells . Regulation NOS3 PECAM1 16118242 1454354 Since a major constituent of these endothelial cell-cell contacts is the platelet endothelial cell adhesion molecule-1 ( PECAM-1 ) we assessed the *role* of in the activation of [eNOS] . Regulation NOS3 PECAM1 21183735 2391100 The current study was conducted to determine the *role* of in the regulation of basal [eNOS] activity . Regulation NOS3 PECAM1 21183735 2391102 Our results reveal an elegant mechanism of [eNOS] *regulation* by through signal transducers and activators of transcription 3-mediated transcriptional control of NOSTRIN . Regulation NOS3 SPHK1 16857953 1600473 *dependent* activation of endothelial [nitric oxide synthase] by angiotensin II . Regulation NOS3 TLR7 10426995 633008 Several lipoproteins stimulated *dependent* transcription of inducible [nitric oxide synthase] and the production of nitric oxide , a powerful microbicidal pathway . Regulation NOS3 TLR7 15994412 1447073 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for tumor necrosis factor ( TNF-alpha ) , interleukin 6 , [nitric oxide synthase-II] ( iNOS ) , and NADPH oxidase 2 (Nox2) . Regulation NOS3 TLR7 21876038 2486769 regulation of SPSB1 *controls* inducible [nitric oxide synthase] induction . Regulation NOS3 TNF 10713108 675825 Beta-amyloid stimulation of inducible [nitric-oxide synthase] in astrocytes is interleukin-1beta- and *dependent* , and involves a TNFalpha receptor associated factor- and NFkappaB inducing kinase dependent signaling mechanism . Regulation NOS3 TNF 10788433 688673 Divergence in *regulation* of [nitric-oxide synthase] and its cofactor tetrahydrobiopterin by . Regulation NOS3 TNF 11035727 741082 The differential *regulation* of [cNOS-] and iNOS mediated NO production by IFN-gamma , , and LPS is discussed . Regulation NOS3 TNF 11160388 781728 beta-Amyloid stimulation of microglia and monocytes results in *dependent* expression of inducible [nitric oxide synthase] and neuronal apoptosis . Regulation NOS3 TNF 11912559 925015 Although the inhibition of IR autophosphorylation by TNF-alpha is known to occur at the adipocyte level , the data on the inhibitory *effect* of on insulin induced [e-NOS] expression and IRP contents are novel . Regulation NOS3 TNF 14555463 1185981 Truncated-promoter analysis indicated the response elements ( -370 ) CACCC , ( -231 ) GATA , and ( -186 ) CACCC may regulate the *effect* of on the [eNOS] promoter . Regulation NOS3 TNF 16827641 1586620 The *role* of in mediating pathophysiological activity of inducible [nitric oxide synthase] during transplant vasculopathy remains contentious . Regulation NOS3 TNF 19353522 2064859 C/EBPbeta knockdown also inhibited the synergistic expression of CXCL1 , inducible [nitric oxide synthase] , and CCL5 in *response* to concomitant IFNgamma and . Regulation NOS3 TNF 20353766 2255175 Pretreatment of HUVEC with an antioxidant ( superoxide dismutase , alpha-tocopherol ) or AT1 receptor blockers ( olmesartan or candesartan ) restored the *dependent* reduction of [eNOS] . Regulation NOS3 TNF 22405819 2577293 Simvastatin blocked the suppressive *effect* on thrombomodulin and [eNOS] , irrespective of shear stress . Regulation NOS3 TNF 23108656 2699217 Moreover , we observed that simvastatin attenuated tumor necrosis factor-a induced upregulation of miR-155 and ameliorated the *effects* of on [eNOS] expression and endothelium dependent vasodilation . Regulation NOS3 TNF 8779862 379930 *Roles* of IL-1 and in endotoxin induced activation of [nitric oxide synthase] in cultured rat brain cells . Regulation NOS3 TNF 9834372 479678 *regulates* inducible [nitric oxide synthase] gene expression in the portal hypertensive gastric mucosa of the rat . Regulation NOS3 TNF 9875639 557210 The *effect* of and interferon-gamma on L-arginine transport , mRNA expression of cationic amino acid transporter and inducible [nitric oxide synthase] , and nitric oxide production of stellate cells was assessed . Regulation NOS3 TNF 9875639 557225 In transformed hepatic stellate cells , and interferon-gamma have a crucial role in nitric oxide production , and extracellular L-arginine transport and inducible [nitric oxide synthase] expression are *regulated* in a differential cytokine-specific manner . Regulation NOS3 TNFSF10 16229016 1517958 Although an important factor that regulates eNOS activity is its localization within the cells , little is known about the *role* of in the regulation of [eNOS] trafficking among cellular compartments and the cytoskeleton involvement in this machinery . Regulation NOTCH1 HBEGF 24188029 2921123 RT-qPCR analysis demonstrated that HB-EGF affected the expression of Notch signaling pathway genes , implying a role for the [Notch] signaling in mediated astrocyte *response* . Regulation NOTCH1 HES2 16682003 1559662 Hrt and negatively *regulate* [Notch] signaling through interactions with RBP-Jkappa . Regulation NOTCH1 JAG1 19598246 2149802 Recently , another Notch ligand , *dependent* [Notch] activation , has been revealed to be important for the determination of the prosensory region in the earlier stage before cell differentiation . Regulation NOTCH1 MAML3 15288260 1278290 Here , we review our current understanding of the *roles* of the proteins in [Notch] signaling , and their involvement in certain human cancers . Regulation NOTCH1 MAML3 18758483 1956639 Here , we review recent studies that have utilized molecular , cellular and physiological model system strategies to reveal the pivotal *roles* of the proteins in [Notch] signaling . Regulation NOTCH1 MAML3 19349467 2057586 *dependent* [Notch1] signaling controls T lineage-specific IL-7R{alpha } gene expression in early human thymopoiesis and leukemia . Regulation NOTCH1 MAML3 21119597 2413974 Finally , in line with the essential *role* of proteins for assembly and activity of the [NOTCH transcriptional complex (NTC)] , we show that MAML derived small-peptide constructs block NOTCH activity and disrupt NTC formation in vitro . Regulation NOTCH1 NRARP 16228014 1489386 These findings reveal that independently *regulates* canonical Wnt and [Notch] signalling by modulating LEF1 and Notch protein turnover , respectively . Regulation NOTCH1 NRARP 19268448 2063140 These include Uncx , a somite gene required for rib and vertebral patterning , and , a *regulator* of [Notch/Wnt] signaling in zebrafish and a cycling gene in mouse . Regulation NOTCH1 NRARP 20960513 2357384 Because overexpression of Notch3 activated the expression of , a negative feedback *regulator* of [Notch] signaling , Notch3 might act as a Notch1 repressor by activating Nrarp . Regulation NOTCH1 TNF 20643108 2340515 Functionally , mediated [Notch] *regulation* promotes caspase dependent EC apoptosis . Regulation NOTCH2 HBEGF 24188029 2921124 RT-qPCR analysis demonstrated that HB-EGF affected the expression of Notch signaling pathway genes , implying a role for the [Notch] signaling in mediated astrocyte *response* . Regulation NOTCH2 HES2 16682003 1559669 Hrt and negatively *regulate* [Notch] signaling through interactions with RBP-Jkappa . Regulation NOTCH2 JAG1 19598246 2149803 Recently , another Notch ligand , *dependent* [Notch] activation , has been revealed to be important for the determination of the prosensory region in the earlier stage before cell differentiation . Regulation NOTCH2 MAML3 15288260 1278293 Here , we review our current understanding of the *roles* of the proteins in [Notch] signaling , and their involvement in certain human cancers . Regulation NOTCH2 MAML3 18758483 1956642 Here , we review recent studies that have utilized molecular , cellular and physiological model system strategies to reveal the pivotal *roles* of the proteins in [Notch] signaling . Regulation NOTCH2 MAML3 21119597 2413977 Finally , in line with the essential *role* of proteins for assembly and activity of the [NOTCH transcriptional complex (NTC)] , we show that MAML derived small-peptide constructs block NOTCH activity and disrupt NTC formation in vitro . Regulation NOTCH2 NRARP 16228014 1489387 These findings reveal that independently *regulates* canonical Wnt and [Notch] signalling by modulating LEF1 and Notch protein turnover , respectively . Regulation NOTCH2 NRARP 19268448 2063141 These include Uncx , a somite gene required for rib and vertebral patterning , and , a *regulator* of [Notch/Wnt] signaling in zebrafish and a cycling gene in mouse . Regulation NOTCH2 NRARP 20960513 2357385 Because overexpression of Notch3 activated the expression of , a negative feedback *regulator* of [Notch] signaling , Notch3 might act as a Notch1 repressor by activating Nrarp . Regulation NOTCH2 TNF 20643108 2340516 Functionally , mediated [Notch] *regulation* promotes caspase dependent EC apoptosis . Regulation NOTCH3 HBEGF 24188029 2921125 RT-qPCR analysis demonstrated that HB-EGF affected the expression of Notch signaling pathway genes , implying a role for the [Notch] signaling in mediated astrocyte *response* . Regulation NOTCH3 HES2 16682003 1559676 Hrt and negatively *regulate* [Notch] signaling through interactions with RBP-Jkappa . Regulation NOTCH3 JAG1 19598246 2149804 Recently , another Notch ligand , *dependent* [Notch] activation , has been revealed to be important for the determination of the prosensory region in the earlier stage before cell differentiation . Regulation NOTCH3 MAML3 15288260 1278296 Here , we review our current understanding of the *roles* of the proteins in [Notch] signaling , and their involvement in certain human cancers . Regulation NOTCH3 MAML3 18758483 1956645 Here , we review recent studies that have utilized molecular , cellular and physiological model system strategies to reveal the pivotal *roles* of the proteins in [Notch] signaling . Regulation NOTCH3 MAML3 21119597 2413980 Finally , in line with the essential *role* of proteins for assembly and activity of the [NOTCH transcriptional complex (NTC)] , we show that MAML derived small-peptide constructs block NOTCH activity and disrupt NTC formation in vitro . Regulation NOTCH3 NRARP 16228014 1489388 These findings reveal that independently *regulates* canonical Wnt and [Notch] signalling by modulating LEF1 and Notch protein turnover , respectively . Regulation NOTCH3 NRARP 19268448 2063142 These include Uncx , a somite gene required for rib and vertebral patterning , and , a *regulator* of [Notch/Wnt] signaling in zebrafish and a cycling gene in mouse . Regulation NOTCH3 NRARP 20960513 2357386 Because overexpression of Notch3 activated the expression of , a negative feedback *regulator* of [Notch] signaling , Notch3 might act as a Notch1 repressor by activating Nrarp . Regulation NOTCH3 TNF 20643108 2340517 Functionally , mediated [Notch] *regulation* promotes caspase dependent EC apoptosis . Regulation NOTCH4 HBEGF 24188029 2921126 RT-qPCR analysis demonstrated that HB-EGF affected the expression of Notch signaling pathway genes , implying a role for the [Notch] signaling in mediated astrocyte *response* . Regulation NOTCH4 HES2 16682003 1559683 Hrt and negatively *regulate* [Notch] signaling through interactions with RBP-Jkappa . Regulation NOTCH4 JAG1 19598246 2149805 Recently , another Notch ligand , *dependent* [Notch] activation , has been revealed to be important for the determination of the prosensory region in the earlier stage before cell differentiation . Regulation NOTCH4 MAML3 15288260 1278299 Here , we review our current understanding of the *roles* of the proteins in [Notch] signaling , and their involvement in certain human cancers . Regulation NOTCH4 MAML3 18758483 1956648 Here , we review recent studies that have utilized molecular , cellular and physiological model system strategies to reveal the pivotal *roles* of the proteins in [Notch] signaling . Regulation NOTCH4 MAML3 21119597 2413983 Finally , in line with the essential *role* of proteins for assembly and activity of the [NOTCH transcriptional complex (NTC)] , we show that MAML derived small-peptide constructs block NOTCH activity and disrupt NTC formation in vitro . Regulation NOTCH4 NRARP 16228014 1489389 These findings reveal that independently *regulates* canonical Wnt and [Notch] signalling by modulating LEF1 and Notch protein turnover , respectively . Regulation NOTCH4 NRARP 19268448 2063143 These include Uncx , a somite gene required for rib and vertebral patterning , and , a *regulator* of [Notch/Wnt] signaling in zebrafish and a cycling gene in mouse . Regulation NOTCH4 NRARP 20960513 2357387 Because overexpression of Notch3 activated the expression of , a negative feedback *regulator* of [Notch] signaling , Notch3 might act as a Notch1 repressor by activating Nrarp . Regulation NOTCH4 TNF 20643108 2340518 Functionally , mediated [Notch] *regulation* promotes caspase dependent EC apoptosis . Regulation NOX1 EPHB2 15894894 1407863 The present research was designed to study the *involvement* of and p38 MAP-kinase in cytosolic phospholipase A2 (cPLA2) and [NADPH-oxidase] activation by angiotensin II (Ang II) in human neutrophils . Regulation NOX1 EPHB2 15894894 1407905 These results suggest that either or p38 MAP-kinase are *involved* in the activation of both cPLA2 and [NADPH oxidase] , and that cPLA2 is required for activation of the NADPH oxidase by Ang II in human neutrophils . Regulation NOX1 EPHB2 18638447 1947616 It was also reported that extracellular signal regulated kinase ( ) 1/2 is *involved* in the expression of [NOX1] . Regulation NOX1 IL1B 14657615 1188524 Therefore , the main objective of this study was to evaluate the *effect* of or NO on enzyme activity of [NADPH oxidase (NOX)] , a superoxide generating system recently documented to participate in a variety of vascular functions . Regulation NOX1 IL1B 16254042 1501806 Analysis of a reporter construct comprising the 2547 bp of the nox1 promoter region revealed that a stimulatory *effect* of on [nox1] transcription is counteracted by an inhibitory effect of IL-1beta evoked endogenous NO formation . Regulation NOX1 IL1B 17673675 1799323 We conclude that in *response* to tumor necrosis factor-alpha and , NADPH oxidase generates ROS within early endosomes and that [Nox1] can not produce sufficient ROS for cell signaling in the absence of ClC-3 . Regulation NOX1 ITGB2 17197441 1702275 We conclude that class IA PI3K serves as a nodal point regulating *dependent* PMN adhesion and activation of [NADPH oxidase] , and leads to oxidant production at sites of PMN adhesion , and the resultant lung microvascular injury in mice . Regulation NOX1 ITGB2 18755982 1992926 *dependent* activation of the neutrophil [NADPH oxidase] during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks . Regulation NOX1 TLR7 22423966 2573034 Autophagy protein Rubicon mediates phagocytic [NADPH oxidase] activation in *response* to microbial infection or stimulation . Regulation NOX1 TNF 14769150 1182384 The aim of this study was to investigate the *effect* of interferon-gamma (IFN-gamma) and on [NADPH oxidase] activity and gp91-phox gene expression in HL-60 clone 15 cells as they differentiate along the eosinophilic lineage . Regulation NOX1 TNF 15643139 1363457 Nicotinamide adenine dinucleotide phosphate ( [NAD(P)H) oxidase] is *regulated* by angiotensin II , interleukin (IL)-1beta and via p38 mitogen activated protein kinase (MAPK) . Regulation NOX1 TNF 16181054 1461871 The aim of this work was to analyze the *effect* of Interferon-gamma (IFN-gamma) and on [NADPH oxidase] activity and gp91-phox gene expression in human colostrum macrophages ( CM ) , peripheral blood monocytes ( PBM ) , and myelomonocytic THP-1 cells . Regulation NOX1 TNF 16997860 1647254 The aim of this study was to consider ( an ) other ( s ) *role* ( s ) for in facilitating the [NADPH-oxidase] activation by these antibodies . Regulation NOX1 TNF 17537988 1784145 To gain a better understanding of the mechanisms involved in [NADPH oxidase] *regulation* by , we evaluated transcriptional regulation of oxidase genes in MonoMac1 cells and human monocytes . Regulation NOX1 TNF 17673675 1799322 We conclude that in *response* to and interleukin-1beta , NADPH oxidase generates ROS within early endosomes and that [Nox1] can not produce sufficient ROS for cell signaling in the absence of ClC-3 . Regulation NOX1 TNF 20065151 2201175 *plays* a role in activation of the polymorphonuclear leukocyte [NADPH oxidase] , thereby contributing to systemic OS , inflammation , and the development of hypertension in this model . Regulation NOX1 TNF 21088376 2413916 PMN generated reactive oxygen species ( ROS ) in *response* to alone , and [NADPH oxidase] activity increased in response to stimulation with formyl-Met-Leu-Phe after priming . Regulation NOX1 TP63 14978110 1213434 These results suggest that p41 ( nox ) and ( nox ) are *involved* in the [Nox1] activation in surface mucous cells of the colon , and besides that , epithelial cells discern pathogenicities among bacteria to appropriately operate Nox1 for the host defense . Regulation NOX3 EPHB2 15894894 1407864 The present research was designed to study the *involvement* of and p38 MAP-kinase in cytosolic phospholipase A2 (cPLA2) and [NADPH-oxidase] activation by angiotensin II (Ang II) in human neutrophils . Regulation NOX3 EPHB2 15894894 1407906 These results suggest that either or p38 MAP-kinase are *involved* in the activation of both cPLA2 and [NADPH oxidase] , and that cPLA2 is required for activation of the NADPH oxidase by Ang II in human neutrophils . Regulation NOX3 IL1B 14657615 1188525 Therefore , the main objective of this study was to evaluate the *effect* of or NO on enzyme activity of [NADPH oxidase (NOX)] , a superoxide generating system recently documented to participate in a variety of vascular functions . Regulation NOX3 ITGB2 17197441 1702277 We conclude that class IA PI3K serves as a nodal point regulating *dependent* PMN adhesion and activation of [NADPH oxidase] , and leads to oxidant production at sites of PMN adhesion , and the resultant lung microvascular injury in mice . Regulation NOX3 ITGB2 18755982 1992928 *dependent* activation of the neutrophil [NADPH oxidase] during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks . Regulation NOX3 TLR7 22423966 2573044 Autophagy protein Rubicon mediates phagocytic [NADPH oxidase] activation in *response* to microbial infection or stimulation . Regulation NOX3 TNF 14769150 1182386 The aim of this study was to investigate the *effect* of interferon-gamma (IFN-gamma) and on [NADPH oxidase] activity and gp91-phox gene expression in HL-60 clone 15 cells as they differentiate along the eosinophilic lineage . Regulation NOX3 TNF 15643139 1363459 Nicotinamide adenine dinucleotide phosphate ( [NAD(P)H) oxidase] is *regulated* by angiotensin II , interleukin (IL)-1beta and via p38 mitogen activated protein kinase (MAPK) . Regulation NOX3 TNF 16181054 1461873 The aim of this work was to analyze the *effect* of Interferon-gamma (IFN-gamma) and on [NADPH oxidase] activity and gp91-phox gene expression in human colostrum macrophages ( CM ) , peripheral blood monocytes ( PBM ) , and myelomonocytic THP-1 cells . Regulation NOX3 TNF 16997860 1647255 The aim of this study was to consider ( an ) other ( s ) *role* ( s ) for in facilitating the [NADPH-oxidase] activation by these antibodies . Regulation NOX3 TNF 17537988 1784146 To gain a better understanding of the mechanisms involved in [NADPH oxidase] *regulation* by , we evaluated transcriptional regulation of oxidase genes in MonoMac1 cells and human monocytes . Regulation NOX3 TNF 20065151 2201176 *plays* a role in activation of the polymorphonuclear leukocyte [NADPH oxidase] , thereby contributing to systemic OS , inflammation , and the development of hypertension in this model . Regulation NOX3 TNF 21088376 2413918 PMN generated reactive oxygen species ( ROS ) in *response* to alone , and [NADPH oxidase] activity increased in response to stimulation with formyl-Met-Leu-Phe after priming . Regulation NOX4 EPHB2 15894894 1407865 The present research was designed to study the *involvement* of and p38 MAP-kinase in cytosolic phospholipase A2 (cPLA2) and [NADPH-oxidase] activation by angiotensin II (Ang II) in human neutrophils . Regulation NOX4 EPHB2 15894894 1407907 These results suggest that either or p38 MAP-kinase are *involved* in the activation of both cPLA2 and [NADPH oxidase] , and that cPLA2 is required for activation of the NADPH oxidase by Ang II in human neutrophils . Regulation NOX4 IL1B 14657615 1188526 Therefore , the main objective of this study was to evaluate the *effect* of or NO on enzyme activity of [NADPH oxidase (NOX)] , a superoxide generating system recently documented to participate in a variety of vascular functions . Regulation NOX4 ITGB2 17197441 1702279 We conclude that class IA PI3K serves as a nodal point regulating *dependent* PMN adhesion and activation of [NADPH oxidase] , and leads to oxidant production at sites of PMN adhesion , and the resultant lung microvascular injury in mice . Regulation NOX4 ITGB2 18755982 1992930 *dependent* activation of the neutrophil [NADPH oxidase] during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks . Regulation NOX4 TLR7 22423966 2573054 Autophagy protein Rubicon mediates phagocytic [NADPH oxidase] activation in *response* to microbial infection or stimulation . Regulation NOX4 TNF 14769150 1182388 The aim of this study was to investigate the *effect* of interferon-gamma (IFN-gamma) and on [NADPH oxidase] activity and gp91-phox gene expression in HL-60 clone 15 cells as they differentiate along the eosinophilic lineage . Regulation NOX4 TNF 15643139 1363461 Nicotinamide adenine dinucleotide phosphate ( [NAD(P)H) oxidase] is *regulated* by angiotensin II , interleukin (IL)-1beta and via p38 mitogen activated protein kinase (MAPK) . Regulation NOX4 TNF 16181054 1461875 The aim of this work was to analyze the *effect* of Interferon-gamma (IFN-gamma) and on [NADPH oxidase] activity and gp91-phox gene expression in human colostrum macrophages ( CM ) , peripheral blood monocytes ( PBM ) , and myelomonocytic THP-1 cells . Regulation NOX4 TNF 16997860 1647256 The aim of this study was to consider ( an ) other ( s ) *role* ( s ) for in facilitating the [NADPH-oxidase] activation by these antibodies . Regulation NOX4 TNF 17537988 1784147 To gain a better understanding of the mechanisms involved in [NADPH oxidase] *regulation* by , we evaluated transcriptional regulation of oxidase genes in MonoMac1 cells and human monocytes . Regulation NOX4 TNF 20065151 2201177 *plays* a role in activation of the polymorphonuclear leukocyte [NADPH oxidase] , thereby contributing to systemic OS , inflammation , and the development of hypertension in this model . Regulation NOX4 TNF 21088376 2413920 PMN generated reactive oxygen species ( ROS ) in *response* to alone , and [NADPH oxidase] activity increased in response to stimulation with formyl-Met-Leu-Phe after priming . Regulation NOX5 EPHB2 15894894 1407862 The present research was designed to study the *involvement* of and p38 MAP-kinase in cytosolic phospholipase A2 (cPLA2) and [NADPH-oxidase] activation by angiotensin II (Ang II) in human neutrophils . Regulation NOX5 EPHB2 15894894 1407904 These results suggest that either or p38 MAP-kinase are *involved* in the activation of both cPLA2 and [NADPH oxidase] , and that cPLA2 is required for activation of the NADPH oxidase by Ang II in human neutrophils . Regulation NOX5 IL1B 14657615 1188523 Therefore , the main objective of this study was to evaluate the *effect* of or NO on enzyme activity of [NADPH oxidase (NOX)] , a superoxide generating system recently documented to participate in a variety of vascular functions . Regulation NOX5 ITGB2 17197441 1702273 We conclude that class IA PI3K serves as a nodal point regulating *dependent* PMN adhesion and activation of [NADPH oxidase] , and leads to oxidant production at sites of PMN adhesion , and the resultant lung microvascular injury in mice . Regulation NOX5 ITGB2 18755982 1992924 *dependent* activation of the neutrophil [NADPH oxidase] during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks . Regulation NOX5 TLR7 22423966 2573014 Autophagy protein Rubicon mediates phagocytic [NADPH oxidase] activation in *response* to microbial infection or stimulation . Regulation NOX5 TNF 14769150 1182380 The aim of this study was to investigate the *effect* of interferon-gamma (IFN-gamma) and on [NADPH oxidase] activity and gp91-phox gene expression in HL-60 clone 15 cells as they differentiate along the eosinophilic lineage . Regulation NOX5 TNF 15643139 1363455 Nicotinamide adenine dinucleotide phosphate ( [NAD(P)H) oxidase] is *regulated* by angiotensin II , interleukin (IL)-1beta and via p38 mitogen activated protein kinase (MAPK) . Regulation NOX5 TNF 16181054 1461867 The aim of this work was to analyze the *effect* of Interferon-gamma (IFN-gamma) and on [NADPH oxidase] activity and gp91-phox gene expression in human colostrum macrophages ( CM ) , peripheral blood monocytes ( PBM ) , and myelomonocytic THP-1 cells . Regulation NOX5 TNF 16997860 1647253 The aim of this study was to consider ( an ) other ( s ) *role* ( s ) for in facilitating the [NADPH-oxidase] activation by these antibodies . Regulation NOX5 TNF 17537988 1784144 To gain a better understanding of the mechanisms involved in [NADPH oxidase] *regulation* by , we evaluated transcriptional regulation of oxidase genes in MonoMac1 cells and human monocytes . Regulation NOX5 TNF 20065151 2201174 *plays* a role in activation of the polymorphonuclear leukocyte [NADPH oxidase] , thereby contributing to systemic OS , inflammation , and the development of hypertension in this model . Regulation NOX5 TNF 21088376 2413914 PMN generated reactive oxygen species ( ROS ) in *response* to alone , and [NADPH oxidase] activity increased in response to stimulation with formyl-Met-Leu-Phe after priming . Regulation NOXO1 TNF 23975421 2942262 Moreover , the microarray analysis and colony formation assay indicated that [NADPH oxidase organizer 1 (Noxo1)] and Gna14 are induced in tumor epithelial cells in a *dependent* manner , and have an important role in tumorigenicity and tumor initiating cell property of gastric cancer cells . Regulation NPNT MYLIP 19844573 2155539 MicroRNA *regulates* [nephronectin] expression modulating osteoblast differentiation by targeting GalNT-7 . Regulation NPNT SMAD1 22842459 2646563 [Nephronectin] expression is *regulated* by signaling in osteoblast-like MC3T3-E1 cells . Regulation NPNT SMAD2 22842459 2646564 [Nephronectin] expression is *regulated* by signaling in osteoblast-like MC3T3-E1 cells . Regulation NPNT SMAD3 22842459 2646565 [Nephronectin] expression is *regulated* by signaling in osteoblast-like MC3T3-E1 cells . Regulation NPNT SMAD4 22842459 2646566 [Nephronectin] expression is *regulated* by signaling in osteoblast-like MC3T3-E1 cells . Regulation NPNT SMAD5 22842459 2646567 [Nephronectin] expression is *regulated* by signaling in osteoblast-like MC3T3-E1 cells . Regulation NPNT SMAD6 22842459 2646568 [Nephronectin] expression is *regulated* by signaling in osteoblast-like MC3T3-E1 cells . Regulation NPNT SMAD7 22842459 2646569 [Nephronectin] expression is *regulated* by signaling in osteoblast-like MC3T3-E1 cells . Regulation NPNT SMAD9 22842459 2646570 [Nephronectin] expression is *regulated* by signaling in osteoblast-like MC3T3-E1 cells . Regulation NPPA EDN2 14716210 1197461 The aim of the present study was to investigate the putative *role* of in mediating ischemia/hypoxia induced [ANP] release utilizing exogenous ET-1 or ET receptor antagonists ( BQ-123 or Bosentan ) . Regulation NPPA EDN2 1828025 158527 These studies provide the first evidence that *regulates* [ANP] gene expression in the brain . Regulation NPPA EDN2 1828025 158530 Additionally , our secretion studies from neurons are consistent with the known stimulatory *effects* of on [ANP] release from the heart . Regulation NPPA EDN2 1828025 158536 The *regulation* of [ANP] production and secretion by the vasoconstrictor peptide is one level at which ANP and endothelin might interact in the in vivo brain . Regulation NPPA EDN2 1838112 176397 The *effects* of epinephrine ( E ) , norepinephrine ( NE ) , angiotensin II ( AII ) , arginine-vasopressin (AVP) and on plasma [ANP] levels were studied according to a latin square design in six 12-21 days-old conscious Jersey calves weighing 30 +/- 4 kg . Regulation NPPA EDN2 2136728 127051 To examine the role of intracellular signals in the regulation of atrial natriuretic peptide (ANP) release , the *effects* of , a putative endogenous agonist for voltage dependent Ca2+ channels on basal and atrial stretch stimulated [ANP] release as well as on hemodynamic parameters ( perfusion pressure , heart rate , contractile force ) in isolated perfused rat hearts were studied . Regulation NPPA EDN2 2163306 136011 The [ANP] secretory *response* to 10 nM was reduced by 65 % with 0.2 mM calcium . Regulation NPPA EDN2 2552240 119079 The *effect* of on the release of [atrial natriuretic peptides (ANP)] was studied in isolated rat atria and in conscious rats . Regulation NPPA GLP1R 23542788 2777714 Cardiomyocyte GLP-1R activation promoted the translocation of the Rap guanine nucleotide exchange factor Epac2 ( also known as Rapgef4 ) to the membrane , whereas Epac2 deficiency eliminated *dependent* stimulation of [ANP] secretion . Regulation NPPA IL1B 10591026 572500 This study was designed to examine the *effects* of on myocyte ( MC ) hypertrophy and the production of [A-type natriuretic peptide (ANP)] and B-type natriuretic peptide ( BNP ) in rat ventricular cardiocyte culture , and to investigate the role of nonmyocyte ( NMC ) in this process . Regulation NPPA IL1B 10591026 572501 We examined the *effects* of on the production of [ANP] and BNP in comparison with the effects of endothelin-1 (ET-1) by using two types of neonatal rat cardiocyte culture ; Regulation NPPA IL1B 8396869 230340 To assess the central *role* of in the release of ACTH , vasopressin ( AVP ) and [atrial natriuretic peptide (ANP)] and in the regulation of blood pressure and thermogenesis , 3 ng ( 0.173 pM ) x 100-1 x BW-1 ( LIL ) , 30 ng ( 1.73 pM ) x 100g-1 x BW-1 ( MIL ) , and 150 ng ( 8.63 pM ) x 100g-1 x BW-1 ( HIL ) of human IL-1 beta dissolved in sterile saline were injected intracerebroventricularly to conscious rats . Regulation NPR1 EDN2 12623978 1066539 We asked whether might *play* a role in the control of basal or osmotically regulated [NPR-A] or eNOS gene expression in these cells . Regulation NPR1 EDN2 12623978 1066545 Although exogenous had little or no *effect* on basal expression of eNOS mRNA or protein or [NPR-A] gene expression , both the type A ( BQ610 ) and type B ( IRL1038 ) endothelin receptor antagonists proved capable of reducing eNOS mRNA and protein expression , and increasing levels of the NPR-A mRNA . Regulation NPR2 TLR7 23818205 2808336 CNP and [NPR-B] showed different characteristic on renal cortex at different pathological period in diabetes rats , and *regulated* their expression . Regulation NPS NT5E 8921261 396779 *Effects* of BDNF and on striatonigral [neuropeptides] or nigral GABA neurons in vivo . Regulation NPTX1 BPI 8040321 266671 and p15A display similar features of antibacterial action distinct from defensin NP-1 , but [NP-1] *acts* synergistically only with BPI and not with p15A . Regulation NPY NT5E 8891268 391934 Moreover , the *effects* of BDNF or and forskolin + PMA on [NPY] production were additive , indicating the involvement of distinct intracellular signalling pathways . Regulation NPY4R TNF 8641197 362843 In this study , the acute *effects* of on insulin stimulated glucose uptake , glycogen synthesis , and protein [phosphatase-1 (PP-1)] activation were examined in cultured rat skeletal muscle cell line , L6 . Regulation NPY4R TNF 8641197 362849 Because GS is activated by dephosphorylation via protein phosphatase-1 (PP-1) , we examined the *effect* of on [PP-1] activation . Regulation NPY4R TNF 8641197 362855 Cell permeable ceramide analogs , C2 , C6 , and Sphingomyelinase mimicked the *effects* of on [PP-1] inhibition . Regulation NQO1 PGC 23648480 2795906 The protein level of , a key metabolic regulator , is *controlled* by [NADH-NQO1] . Regulation NR1I2 IL1B 20460758 2257489 However , rifampicin the nuclear receptor steroid and xenobiotic receptor (SXR) ligand had no effect of IL-beta , suggesting that is *involved* in VK ( 2 ) dependent gamma-calboxylation but not [SXR-activation] . Regulation NR1I3 TNF 14664720 1177714 had no *effect* on PTH secretion , and PTH and [CaR] mRNA expression . Regulation NR2F1 HNF4A 1639815 194734 The finding that , ARP-1 , EAR-2 and [EAR-3] can *regulate* the expression of the apoB , apoCIII , and apoAII genes suggest that these nuclear hormone receptors may be an important part of the signal transduction pathways modulating lipid metabolism and cholesterol homeostasis . Regulation NR2F1 MAPK1 12040019 949620 Focusing on the molecular mechanisms underlying the and PKC mediated *regulation* of [COUP-TFI] activity , we show that COUP-TFI can be directly targeted by PKC and MAPK . Regulation NR2F1 MAPK10 12040019 949621 Focusing on the molecular mechanisms underlying the and PKC mediated *regulation* of [COUP-TFI] activity , we show that COUP-TFI can be directly targeted by PKC and MAPK . Regulation NR2F1 MAPK11 12040019 949622 Focusing on the molecular mechanisms underlying the and PKC mediated *regulation* of [COUP-TFI] activity , we show that COUP-TFI can be directly targeted by PKC and MAPK . Regulation NR2F1 MAPK12 12040019 949623 Focusing on the molecular mechanisms underlying the and PKC mediated *regulation* of [COUP-TFI] activity , we show that COUP-TFI can be directly targeted by PKC and MAPK . Regulation NR2F1 MAPK13 12040019 949624 Focusing on the molecular mechanisms underlying the and PKC mediated *regulation* of [COUP-TFI] activity , we show that COUP-TFI can be directly targeted by PKC and MAPK . Regulation NR2F1 MAPK14 12040019 949625 Focusing on the molecular mechanisms underlying the and PKC mediated *regulation* of [COUP-TFI] activity , we show that COUP-TFI can be directly targeted by PKC and MAPK . Regulation NR2F1 MAPK15 12040019 949619 Focusing on the molecular mechanisms underlying the and PKC mediated *regulation* of [COUP-TFI] activity , we show that COUP-TFI can be directly targeted by PKC and MAPK . Regulation NR2F1 MAPK3 12040019 949626 Focusing on the molecular mechanisms underlying the and PKC mediated *regulation* of [COUP-TFI] activity , we show that COUP-TFI can be directly targeted by PKC and MAPK . Regulation NR2F1 MAPK4 12040019 949627 Focusing on the molecular mechanisms underlying the and PKC mediated *regulation* of [COUP-TFI] activity , we show that COUP-TFI can be directly targeted by PKC and MAPK . Regulation NR2F1 MAPK6 12040019 949628 Focusing on the molecular mechanisms underlying the and PKC mediated *regulation* of [COUP-TFI] activity , we show that COUP-TFI can be directly targeted by PKC and MAPK . Regulation NR2F1 MAPK7 12040019 949629 Focusing on the molecular mechanisms underlying the and PKC mediated *regulation* of [COUP-TFI] activity , we show that COUP-TFI can be directly targeted by PKC and MAPK . Regulation NR2F1 MAPK8 12040019 949630 Focusing on the molecular mechanisms underlying the and PKC mediated *regulation* of [COUP-TFI] activity , we show that COUP-TFI can be directly targeted by PKC and MAPK . Regulation NR2F1 MAPK9 12040019 949631 Focusing on the molecular mechanisms underlying the and PKC mediated *regulation* of [COUP-TFI] activity , we show that COUP-TFI can be directly targeted by PKC and MAPK . Regulation NR2F1 MOCOS 23785296 2802475 Global gene expression analysis by RNA-seq revealed that in the mouse mammary gland , the orphan nuclear receptor gene [Nr2f1/Coup-tf1] is *regulated* by . Regulation NR2F1 MOCOS 23785296 2802477 Our data suggest that the non-protein coding locus *regulates* [Nr2f1] , which is a candidate modifier of differentiation , proliferation , and mammary cancer risk . Regulation NR2F1 NR2F2 1639815 194735 The finding that HNF-4 , , EAR-2 and [EAR-3] can *regulate* the expression of the apoB , apoCIII , and apoAII genes suggest that these nuclear hormone receptors may be an important part of the signal transduction pathways modulating lipid metabolism and cholesterol homeostasis . Regulation NR3C1 NES 23072594 2727043 and vimentin colocalization *affects* the subcellular location of [glucocorticoid receptor] in cutaneous melanoma . Regulation NR3C1 RNASE1 3790497 66325 *Effects* of bovine pancreatic , S protein , and S peptide on activation of purified rat hepatic [glucocorticoid-receptor] complexes . Regulation NR4A1 EPHB2 22186412 2543390 These results further clarify the *role* of and PKC signaling in regulation of the GnRH induced immediate early gene program as well as GnRH induced transcription stimulating activity of [Nur77] in the gonadotrope and shed new light on the complex functional organization of this signaling pathway in the pituitary gonadotrope . Regulation NR4A1 TNF 18180317 1856498 Taken together , these observations suggest that GLP-1 inhibits mediated PAI-1 induction in vascular endothelial cells , and this effect may *involve* Akt mediated signalling events and the modulation of [Nur77] expression and NP binding to the PAI-1 NBRE . Regulation NR4A2 EPHB2 15106839 1240581 Differential *role* of in cAMP induced [Nurr1] expression in N2A and C6 cells . Regulation NR4A2 FOXA1 17596284 1768251 Subsequently , and Foxa2 *regulate* the expression of [Nurr1] ( Nr4a2 ) and engrailed 1 in immature neurons and the expression of aromatic l-amino acid decarboxylase and tyrosine hydroxylase in mature neurons during early and late differentiation of midbrain dopaminergic neurons . Regulation NR4A2 STK39 15485875 1342678 Receptor tyrosine kinase activators had minimal effect , whereas activators had no *effect* on basal [Nurr1] mRNA levels . Regulation NR5A1 EPHB2 11410589 849760 This conclusion was supported by our demonstration of an *dependent* increase in the binding of [SF-1] from FSK treated Y1 nuclei to three consensus double stranded DNA sequences from the StAR promoter region . Regulation NR5A2 PGC 23471216 2760765 These results indicate that the expression of human [LRH-1] is regulated in a tissue-specific manner , and that the novel promoter region is *controlled* by the Sp-family , NR5A-family and in ovarian granulosa cells in a coordinated fashion . Regulation NR5A2 TNF 12837754 1134698 These results indicate that induction of Mrp3 after BDL is due to *dependent* up-regulation of [Lrh-1] . Regulation NRARP NOTCH1 11783997 891468 Thus , [Nrarp] transcript levels are *regulated* by the level of signaling in both cultured cell lines and mouse embryos . Regulation NRAS AXIN2 17374607 1734763 The [Ras] *regulation* by was blocked by treatment of leupeptin , an inhibitor of the lysosomal protein degradation machinery . Regulation NRAS EPHB2 10978313 751961 Whereas the essential *roles* of and JNK in [Ras] signaling has been established , the contribution of p38 remains unclear . Regulation NRAS EPHB2 17724343 1789873 Subcellular compartmentalization has become an important theme in cell signaling such as spatial *regulation* of [Ras] by RasGRP1 and by Sef . Regulation NRAS EPHB2 17873330 1796093 The aim of this work is to evaluate if [Ras] can be induced by TSH in rat thyroids , and whether may be *involved* in the subsequent intracellular signalling cascade . Regulation NRAS EPHB2 20392691 2273732 The promoter of the Nol3 locus , encoding ARC , is activated by [N-Ras] and H-Ras in a *dependent* manner . Regulation NRAS EPHB2 21277645 2457910 Furthermore , , a critical growth *regulator* downstream of [RAS] , may play a role . Regulation NRAS FAS 20418879 2262479 Small-molecule inhibition of *affects* [Ras] localization and signaling . Regulation NRAS FHL1 23456229 2781841 The misexpression of FHL1 transcripts precipitated by this mutation , together with the *role* of in the regulation of [RAS-MAPK] signalling , suggests that this mutation confers a complex phenotype through both gain- and loss-of-function mechanisms . Regulation NRAS GPR115 14656216 1177085 Role of receptor tyrosine kinases in *regulation* of [Ras] : transactivation or parallel pathways ? Regulation NRAS GPR132 14656216 1177074 Role of receptor tyrosine kinases in *regulation* of [Ras] : transactivation or parallel pathways ? Regulation NRAS GPR87 14656216 1177154 Role of receptor tyrosine kinases in *regulation* of [Ras] : transactivation or parallel pathways ? Regulation NRAS MAP2K6 17724343 1789879 Subcellular compartmentalization has become an important theme in cell signaling such as spatial *regulation* of [Ras] by RasGRP1 and by Sef . Regulation NRAS MAP2K6 20392691 2273738 The promoter of the Nol3 locus , encoding ARC , is activated by [N-Ras] and H-Ras in a *dependent* manner . Regulation NRIP1 FHL1 19401155 2070362 Furthermore , overexpression of the deletion mutant that lacks the RIP140 binding sites had no *effect* on [RIP140] repression of estrogen signaling . Regulation NRP1 EPHB2 20141840 2208144 Mechanistically , K5-SOS upregulates VEGF , Flt1 , and [Neuropilin-1] in an *dependent* manner , thereby activating an autocrine proliferation loop , whereas EGFR prevents tumor cells from apoptosis . Regulation NRP1 MAOA 24865426 2945523 *dependent* activation of [neuropilin-1] promoted AKT/FOXO1/TWIST1 signaling , allowing FOXO1 binding at the TWIST1 promoter . Regulation NRP1 TNF 12613541 1030020 [NRP1] expression is *regulated* in EC by , the transcription factors dHAND and Ets-1 , and vascular injury . Regulation NRP1 TNF 9705358 526022 *regulates* expression of vascular endothelial growth factor receptor-2 and of its co-receptor [neuropilin-1] in human vascular endothelial cells . Regulation NRTN TNF 12960779 1138492 Lipopolysaccharide and *regulate* the expression of GDNF , [neurturin] and their receptors . Regulation NT5C CFI 17538026 1773225 Like Net1/Cfi1 , [Dnt1] is required for rDNA silencing and minichromosome maintenance , and both Dnt1 and negatively *regulate* the homologous SIN and MEN pathways . Regulation NT5E ARG1 12615083 1065432 In the present study , we investigated the in vitro *effects* of , NA , AA and HA on NTPDase1 and [5'-nucleotidase] activities from synaptosomal cerebral cortex of rats . Regulation NT5E ARG2 12615083 1065433 In the present study , we investigated the in vitro *effects* of , NA , AA and HA on NTPDase1 and [5'-nucleotidase] activities from synaptosomal cerebral cortex of rats . Regulation NT5E C5 8348695 227042 Ecto-5'-nucleotidase activity of polymorphonuclear leukocytes was attenuated by both FMLP and complement C5a ( 22.7 +/- 3.6 vs 9.7 +/- 2.6 nmol/min per 10 ( 7 ) cells at 10 ( -6 ) M FMLP , P < .05 ; 21.5 +/- 2.2 vs 10.2 +/- 1.2 nmol/min per 10 ( 7 ) cells at 5 x 10 ( -7 ) g/mL complement C5a , P < .001 ) , whereas cytosolic [5'-nucleotidase] activity was not *affected* by either FMLP or . Regulation NT5E CAT 21869566 2477754 Although Fe ( 2+ ) is known to increase oxidative stress , Fe ( 2+ ) -mediated oxidative stress was not involved in SNP inhibition of NT5E because the inhibition of [NT5E] by SNP was not *affected* by superoxide dismutase and . Regulation NT5E CD38 10229870 611245 The aim of this study was 2-fold : first , to characterize the mechanisms by which *regulates* [CD73] expression ; Regulation NT5E EGF 9851317 554372 In contrast , genistein ( 10 mg x ml(-1) ) , an inhibitor of tyrosine kinase , prevented *dependent* stimulation of aminopeptidase N and [5'-nucleotidase] , suggesting that protein phosphorylation was involved in the signaling mechanism . Regulation NT5E ESR1 14760094 1206880 *Role* of in the regulation of [ecto-5'-nucleotidase] and adenosine in breast cancer . Regulation NT5E IFNB1 18825744 1981590 *regulates* [CD73] and adenosine expression at the blood-brain barrier . Regulation NT5E IFNB1 24503265 2914098 The *effect* of intravenous ( FP-1201 ) on lung [CD73] expression and on acute respiratory distress syndrome mortality : an open-label study . Regulation NT5E IL4 1557611 184482 On BMC from 3 patients with hypogammaglobulinaemia , the *effect* of on the level of [ecto-5'-NT] activity was identical to that found on BMC from healthy donors , whereas PGE2 increased ecto-5'-NT activity on BMC from only 1 of the 3 patients investigated . Regulation NT5E INS 3004038 55085 [ Age dependent characteristics of the *effect* of on [5'-nucleotidase] activity in liver plasma membranes ] . Regulation NT5E MCM2 2550695 117620 The *effect* of on [ecto-5'-nucleotidase] activity was apparent after 24 hours and increased with time . Regulation NT5E MCM3 2550695 117621 The *effect* of on [ecto-5'-nucleotidase] activity was apparent after 24 hours and increased with time . Regulation NT5E MCM4 2550695 117622 The *effect* of on [ecto-5'-nucleotidase] activity was apparent after 24 hours and increased with time . Regulation NT5E MCM5 2550695 117623 The *effect* of on [ecto-5'-nucleotidase] activity was apparent after 24 hours and increased with time . Regulation NT5E MCM6 2550695 117624 The *effect* of on [ecto-5'-nucleotidase] activity was apparent after 24 hours and increased with time . Regulation NT5E MCM7 2550695 117625 The *effect* of on [ecto-5'-nucleotidase] activity was apparent after 24 hours and increased with time . Regulation NT5E MCOLN1 15478804 1319765 Expression in Pichia pastoris resulted in the secretion of an active enzyme with the catalytic properties of both a *dependent* diphosphohydrolase/apyrase and a [5'-nucleotidase] . Regulation NT5E MCOLN1 8498566 220844 These data suggest that the *regulation* of AMP-specific cytosolic [5'-nucleotidase] by adenine nucleotides and free may be important in the production of adenosine during conditions promoting ATP hydrolysis , such as myocardial hypoxia or ischemia . Regulation NT5E PRKCA 9345290 459368 *Role* of in activation of [ecto-5'-nucleotidase] in the preconditioned canine myocardium . Regulation NT5E SETD2 21057730 2344658 [CD73] activity is primarily regulated at the level of transcription in *response* to the oxygen sensing transcription factor , and its tissue-specific expression correlates negatively with oxygen tension . Regulation NT5E SETD2 21057730 2344660 *dependent* induction of [CD73] contributes to the protective effects of hypoxia in the inflamed intestinal mucosa . Regulation NT5E SOD1 21869566 2477751 Although Fe ( 2+ ) is known to increase oxidative stress , Fe ( 2+ ) -mediated oxidative stress was not involved in SNP inhibition of NT5E because the inhibition of [NT5E] by SNP was not *affected* by and catalase . Regulation NT5E SOD2 21869566 2477752 Although Fe ( 2+ ) is known to increase oxidative stress , Fe ( 2+ ) -mediated oxidative stress was not involved in SNP inhibition of NT5E because the inhibition of [NT5E] by SNP was not *affected* by and catalase . Regulation NT5E SOD3 21869566 2477753 Although Fe ( 2+ ) is known to increase oxidative stress , Fe ( 2+ ) -mediated oxidative stress was not involved in SNP inhibition of NT5E because the inhibition of [NT5E] by SNP was not *affected* by and catalase . Regulation NT5E TNF 12030367 947622 *Regulation* of [ecto-5'-nucleotidase] by in human endothelial cells . Regulation NT5E TNF 2165999 137871 Taken together , these results indicate that IL-1 beta , essentially , and , to a lesser extent , *regulate* [5'-nucleotidase] expression in the plasma membrane of cultured mesangial cells and that their effect depends in part on PGE2 synthesis . Regulation NT5E TNF 22750273 2681908 We have studied *effects* of several pro-inflammatory factors , namely , bacterial endotoxin lipopolysaccharide (LPS) , , interferon-? ( IFN-? ) , glutamate ( Glu ) and hydrogen peroxide ( H ( 2 ) O ( 2 ) ) on [e-5NT] ( i ) activity , ( ii ) mRNA expression and ( iii ) membrane protein abundance in primary cultured cortical astrocytes . Regulation NTF3 NGFR 9038213 415420 These results suggest that the NGF effect is mediated by the high affinity , Trk A and that [neurotrophin] binding to the low affinity neurotrophin receptor , p75(NTR) , alone does not *affect* the promoter activity . Regulation NTF4 NGFR 9038213 415421 These results suggest that the NGF effect is mediated by the high affinity , Trk A and that [neurotrophin] binding to the low affinity neurotrophin receptor , p75(NTR) , alone does not *affect* the promoter activity . Regulation NTN1 ITGB2 8097379 217647 In light of the ability of CD18 integrins to participate in leukocyte adherence ( and thereby migration ) , we examined the *role* of the integrin in [NTN] using OX42 , a monoclonal antibody directed against rat CD11b . Regulation NTN3 ITGB2 8097379 217649 In light of the ability of CD18 integrins to participate in leukocyte adherence ( and thereby migration ) , we examined the *role* of the integrin in [NTN] using OX42 , a monoclonal antibody directed against rat CD11b . Regulation NTN4 ITGB2 8097379 217643 In light of the ability of CD18 integrins to participate in leukocyte adherence ( and thereby migration ) , we examined the *role* of the integrin in [NTN] using OX42 , a monoclonal antibody directed against rat CD11b . Regulation NTN5 ITGB2 8097379 217645 In light of the ability of CD18 integrins to participate in leukocyte adherence ( and thereby migration ) , we examined the *role* of the integrin in [NTN] using OX42 , a monoclonal antibody directed against rat CD11b . Regulation NTRK1 EPHB2 18758136 1968969 Analysis of the common features of the augmented pathways suggests that [TrkA] is most likely to be the primary target of MCC-257 and that both and Akt may be *involved* in the cellular effects of this compound . Regulation NTRK2 EPHB2 20739478 2401403 Dissection of the intracellular pathway that underlies this process revealed that [BDNF/TrkB] signaling controls the transcription of GAD65 in a *dependent* manner . Regulation NTS TNF 1372239 182934 Interleukin-1 alpha and differentially *regulate* enkephalin , vasoactive intestinal polypeptide , [neurotensin] , and substance P biosynthesis in chromaffin cells . Regulation NTSR1 EPHB2 20663927 2305277 The purpose of our current study was to determine : ( a ) whether HDACi alters NTR1 expression and function , and ( b ) the *role* of in [NTR1] regulation . Regulation NUDC STK39 18083840 1837902 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation NUP153 IFI27 12490316 1033152 To clarify the *roles* of and c-myc in [nasopharyngeal carcinoma (NPC)] , we used immunohistochemical studies to examine the expression of p27 and c-myc proteins in 69 patients with NPC . Regulation NUP210 IFI27 12490316 1033151 To clarify the *roles* of and c-myc in [nasopharyngeal carcinoma (NPC)] , we used immunohistochemical studies to examine the expression of p27 and c-myc proteins in 69 patients with NPC . Regulation NUP214 IFI27 12490316 1033153 To clarify the *roles* of and c-myc in [nasopharyngeal carcinoma (NPC)] , we used immunohistochemical studies to examine the expression of p27 and c-myc proteins in 69 patients with NPC . Regulation NUP43 CD14 7521366 269325 *dependent* activation of protein kinase C and mitogen activated protein kinases ( [p42] and p44 ) in human monocytes treated with bacterial lipopolysaccharide . Regulation NUP43 CD14 7561108 324193 Lipopolysaccharide stimulates the tyrosine phosphorylation of mitogen activated protein kinases p44 , [p42] , and p41 in vascular endothelial cells in a soluble *dependent* manner . Regulation NUP43 LBP 11134043 794924 Here we show that secretion of tumor necrosis factor-alpha induced by Treponema culture supernatants and extracted LTA was paralleled by an *dependent* phosphorylation of mitogen activated protein kinases ( MAPKs ) [p42] and p44 , and p38 , as well as the stress activated protein kinases c-Jun N-terminal kinases 1 and 2 . Regulation NUP43 MAP2K6 15064239 1231159 These results suggest that in HTSMCs , LTA stimulated [p42/p44] MAPK phosphorylation is mediated through a TLR2 receptor and *involves* tyrosine kinase , PLC , PKC , Ca ( 2+ ) , , and PI 3-kinase . Regulation NUP62 IFI27 12490316 1033154 To clarify the *roles* of and c-myc in [nasopharyngeal carcinoma (NPC)] , we used immunohistochemical studies to examine the expression of p27 and c-myc proteins in 69 patients with NPC . Regulation OASL DDX58 24931123 2946936 Conversely , [OASL] expression suppressed replication of a number of viruses in a *dependent* manner and enhanced RIG-I mediated IFN induction . Regulation OAT TNF 22989455 2674410 In the 54 selected binary interactions of [OAT] , and TRAF6 *play* roles in the NF-?B pathway . Regulation OCLN ANGPT1 17332770 1834988 To determine the *effects* of pericytes and on the expression of [occludin] and zonula occludens-1 (ZO-1) in retinal endothelial cells ( ECs ) under both normoxic and hypoxic conditions . Regulation OCLN ANGPT1 23894369 2821835 Recombinant human sonic hedgehog protein *regulates* the expression of ZO-1 and [occludin] by activating in stroke damage . Regulation OCLN IL1B 15350541 1292420 *regulates* expression of Cx32 , [occludin] , and claudin-2 of rat hepatocytes via distinct signal transduction pathways . Regulation OCLN IL1B 19171646 2027687 The NF-kappaB inhibitor curcumin blocked the *effects* of on both TER and the subcellular localization of ZO-1 and [occludin] . Regulation OCLN TNF 18235000 1864341 The abundance of neither ZO-1 nor [occludin] was *affected* by . Regulation OCLN TNF 20445948 2257055 Western blot results indicated that decreased the expression of phosphorylated occludin in detergent-insoluble fractions but did not *affect* the expression of non phosphorylated [occludin] protein . Regulation OCLN TNF 22848704 2635923 Our data demonstrate that the previously established efficacy of VSL # 3 in preventing SAMP ileitis is due to direct innate and homeostatic *effects* of on the gut epithelium , modulation of the TJ proteins , claudin-2 and [occludin] , and overall improvement of intestinal permeability . Regulation ODC1 EPHB2 18367589 1906548 The data illustrated that PD-98059 , a MEK ( MAPK kinase ) inhibitor , LY-294002 , a phosphatidylinositol 3-kinase (PI3K) inhibitor , and H-89 , a protein kinase A (PKA) inhibitor , substantially decreased the induction of ODC catalytic activity and ODC mRNA expression induced by IL-4 and IL-13 , suggesting positive *regulation* of the [ODC] gene by , PI3K , and PKA pathways . Regulation ODC1 TNF 1641775 194826 The purpose of this study was to determine whether interleukin-1 (IL-1) or , which are released immediately after injury , *regulates* gut mucosal [ODC] enzyme activity and gene expression . Regulation OLFM4 NOTCH1 22190634 2537355 Analysis of Notch function in Atoh1-deficient intestine demonstrated that the cellular changes were dependent on Atoh1 , whereas *regulation* of [Olfm4] gene expression was Atoh1 independent . Regulation OLFM4 NOTCH2 22190634 2537356 Analysis of Notch function in Atoh1-deficient intestine demonstrated that the cellular changes were dependent on Atoh1 , whereas *regulation* of [Olfm4] gene expression was Atoh1 independent . Regulation OLFM4 NOTCH3 22190634 2537357 Analysis of Notch function in Atoh1-deficient intestine demonstrated that the cellular changes were dependent on Atoh1 , whereas *regulation* of [Olfm4] gene expression was Atoh1 independent . Regulation OLFM4 NOTCH4 22190634 2537358 Analysis of Notch function in Atoh1-deficient intestine demonstrated that the cellular changes were dependent on Atoh1 , whereas *regulation* of [Olfm4] gene expression was Atoh1 independent . Regulation OLIG2 EPHB2 22901811 2647437 Here , we show that biallelic Nf1 inactivation promotes *dependent* , ectopic [Olig2] expression specifically in transit amplifying progenitors , leading to increased gliogenesis at the expense of neurogenesis in neonatal and adult subventricular zone ( SVZ ) . Regulation OLR1 TNF 12958047 1174110 [LOX-1] , a novel lectin-like receptor for oxidized LDL ( ox-LDL ) , is expressed in *response* to ox-LDL , angiotensin II (Ang II) , , and other stress stimuli . Regulation ONECUT1 FOXA1 15562441 1343457 We investigated how [HNF-6] *controls* the expression of . Regulation OPA1 ALOX5 1701029 144996 To address the hypothesis that stimulated leukotriene synthesis causes symptoms of immediate-hypersensitivity reactions in vivo , I investigated the *effects* of a new <5-lipoxygenase> inhibitor , A-64077 , on provoked allergic nasal symptoms and [mediator] release in a double-blind , randomized , placebo controlled study . Regulation OPA1 CD14 12435950 1016114 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation OPA1 F2R 19205424 2007302 Our data indicated that blockade of the mast cells proinflammatory [mediator] secretion by APC *involved* activation . Regulation OPA1 F2R 9141614 428506 The *role* of the in fibroblast dependent release of the inflammatory [mediator] prostaglandin E2 was evaluated and compared to its well characterized effect on cell proliferation . Regulation OPA1 IL1B 11132773 760340 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to and TNF-alpha , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation OPA1 LBP 12435950 1016115 The aim of this study was to investigate the relationship between endotoxin translocation and tissue LBP/CD14 messenger ribonucleic acid ( mRNA ) expression after burn injury , and to define the potential *role* of in mediating inflammatory [mediator] induction , as well as the pathogenesis of organ damage . Regulation OPA1 TLR7 17264163 1733103 We investigated the *effects* of activation on lipid [mediator] production in polymorphonuclear leukocytes exposed to R-848 . Regulation OPA1 TLR7 18584038 1931105 We performed a comprehensive survey on the efficacy of various PPAR-gamma agonists to modulate proinflammatory [mediator] release from primary microglia and astrocytes in *response* to numerous ligands relevant to CNS infectious diseases . Regulation OPA1 TNF 11132773 760339 ( 1 ) allergic asthmatic serum ( AAS ) modulates ASMC [mediator] release in *response* to IL-1beta and , and ( 2 ) IL-1beta/TNF-alpha prime ASMC to release mediators in response to AAS . Regulation OPA1 TNF 18768838 1957108 Since TLR2 is critical for signaling astrocytic cytokine production in response to S. aureus , we evaluated the *effect* of loss on proinflammatory [mediator] release . Regulation OPA1 TNF 23453807 2756104 Notably , in parkin-deficient cells linear ubiquitination of NEMO , activation of NF-?B , and upregulation of [OPA1] are significantly reduced in *response* to stimulation , supporting the physiological relevance of parkin in regulating this antiapoptotic pathway . Regulation OPN1LW TNF 19596989 2112078 This study illustrates a novel biological *role* of in increasing neuron-specific expression of [CBP] for preconditioning that may have therapeutic potential against neurodegenerative disorders . Regulation OPRM1 GPR115 10698001 671637 To investigate the functional *role* of in homologous desensitization of the [mu-opioid receptor] , human embryonic kidney (HEK) 293 cells , which express a significant level of GRK2 , were stably transfected with the cDNA encoding the rat mu-opioid receptor . Regulation OPRM1 GPR132 10698001 671626 To investigate the functional *role* of in homologous desensitization of the [mu-opioid receptor] , human embryonic kidney (HEK) 293 cells , which express a significant level of GRK2 , were stably transfected with the cDNA encoding the rat mu-opioid receptor . Regulation OPRM1 GPR87 10698001 671706 To investigate the functional *role* of in homologous desensitization of the [mu-opioid receptor] , human embryonic kidney (HEK) 293 cells , which express a significant level of GRK2 , were stably transfected with the cDNA encoding the rat mu-opioid receptor . Regulation OPRM1 TNF 14500744 1144270 The role of nuclear factor kappaB in *regulated* transcription of the human [mu-opioid receptor] gene . Regulation OPRM1 TNF 16914208 1646364 Earlier investigations demonstrated up-regulated [mu-opioid receptor] expression in neuronal and immune cells in *response* to IL-1 , IL-4 , IL-6 and . Regulation OPTN TNF 9488477 488977 These data suggest that [FIP-2] is one of the cellular targets for Ad E3-14.7K and that its mechanism of affecting cell death *involves* the receptor , RIP , or a downstream molecule affected by either of these two molecules . Regulation OR10A4 RNASE1 19320830 2064412 These findings suggest that [hp2] *controls* E synthesis by binding to RNase E and expediting cleavage elsewhere within the rne transcript . Regulation OR10A4 RNASE7 19320830 2064420 These findings suggest that [hp2] *controls* E synthesis by binding to RNase E and expediting cleavage elsewhere within the rne transcript . Regulation OSM EPHB2 18398932 1899463 [OSM] induction was MAP kinase *dependent* , p38 requiring but JNK independent . Regulation OSM MAP2K6 17226768 1771596 Whereas , the JAK3 inhibitor , WHI-P131 , and the inhibitor , U0126 , had no *effects* on the anti-adipogenic activity of [OSM] . Regulation OSR1 BMP1 22791896 2634636 Our data suggest that [Osr1/Osr2] normally repress bmp4 expression in the lpm , and that signaling negatively *regulates* the wnt2b domain . Regulation OSR1 BMP10 22791896 2634644 Our data suggest that [Osr1/Osr2] normally repress bmp4 expression in the lpm , and that signaling negatively *regulates* the wnt2b domain . Regulation OSR1 BMP15 22791896 2634637 Our data suggest that [Osr1/Osr2] normally repress bmp4 expression in the lpm , and that signaling negatively *regulates* the wnt2b domain . Regulation OSR1 BMP2 22791896 2634638 Our data suggest that [Osr1/Osr2] normally repress bmp4 expression in the lpm , and that signaling negatively *regulates* the wnt2b domain . Regulation OSR1 BMP3 22791896 2634639 Our data suggest that [Osr1/Osr2] normally repress bmp4 expression in the lpm , and that signaling negatively *regulates* the wnt2b domain . Regulation OSR1 BMP4 22791896 2634640 Our data suggest that [Osr1/Osr2] normally repress bmp4 expression in the lpm , and that signaling negatively *regulates* the wnt2b domain . Regulation OSR1 BMP5 22791896 2634641 Our data suggest that [Osr1/Osr2] normally repress bmp4 expression in the lpm , and that signaling negatively *regulates* the wnt2b domain . Regulation OSR1 BMP6 22791896 2634642 Our data suggest that [Osr1/Osr2] normally repress bmp4 expression in the lpm , and that signaling negatively *regulates* the wnt2b domain . Regulation OSR1 BMP7 22791896 2634643 Our data suggest that [Osr1/Osr2] normally repress bmp4 expression in the lpm , and that signaling negatively *regulates* the wnt2b domain . Regulation OSR1 CAP1 19395663 2089448 , a transcription factor of the basic region leucine zipper family , *regulates* the [oxidative stress response (OSR)] in Candida albicans . Regulation OSR1 IKZF1 18804520 1981230 These findings indicate that [Osr1] expression is *regulated* by Runx2 and , which are known as master-gene of osteogenesis and hematopoiesis , respectively . Regulation OSR1 MT-CO2 7485922 326882 We tested three devices used for differentiating oesophageal from endotracheal intubation : 1. *dependent* [Oesophageal Detector Device (ODD)] as described by Pollard and Wee , 2 . Regulation OSR1 PRKAA1 24808538 2944742 Activation of the with no lysine kinase/SPAK/OSR1 pathway with low-NaCl solution invoked a greater elevation in phospho-SPAK/phospho-OSR1 in AMPK ( -/- ) MEFs than in AMPK ( +/+ ) MEFs , consistent with a negative regulatory *effect* of on [SPAK/OSR1] phosphorylation . Regulation OSR1 PRKAA1 24808538 2944754 In conclusion , this study identifies increased phosphorylation of NKCC2 on S126 as a hitherto unrecognized mediator of enhanced Na ( + ) reabsorption in obesity and identifies a new *role* for in regulating the activity of [SPAK/OSR1] . Regulation OSR1 PRKAA2 24808538 2944743 Activation of the with no lysine kinase/SPAK/OSR1 pathway with low-NaCl solution invoked a greater elevation in phospho-SPAK/phospho-OSR1 in AMPK ( -/- ) MEFs than in AMPK ( +/+ ) MEFs , consistent with a negative regulatory *effect* of on [SPAK/OSR1] phosphorylation . Regulation OSR1 PRKAA2 24808538 2944755 In conclusion , this study identifies increased phosphorylation of NKCC2 on S126 as a hitherto unrecognized mediator of enhanced Na ( + ) reabsorption in obesity and identifies a new *role* for in regulating the activity of [SPAK/OSR1] . Regulation OSR1 PRKAB1 24808538 2944744 Activation of the with no lysine kinase/SPAK/OSR1 pathway with low-NaCl solution invoked a greater elevation in phospho-SPAK/phospho-OSR1 in AMPK ( -/- ) MEFs than in AMPK ( +/+ ) MEFs , consistent with a negative regulatory *effect* of on [SPAK/OSR1] phosphorylation . Regulation OSR1 PRKAB1 24808538 2944756 In conclusion , this study identifies increased phosphorylation of NKCC2 on S126 as a hitherto unrecognized mediator of enhanced Na ( + ) reabsorption in obesity and identifies a new *role* for in regulating the activity of [SPAK/OSR1] . Regulation OSR1 PRKAB2 24808538 2944745 Activation of the with no lysine kinase/SPAK/OSR1 pathway with low-NaCl solution invoked a greater elevation in phospho-SPAK/phospho-OSR1 in AMPK ( -/- ) MEFs than in AMPK ( +/+ ) MEFs , consistent with a negative regulatory *effect* of on [SPAK/OSR1] phosphorylation . Regulation OSR1 PRKAB2 24808538 2944757 In conclusion , this study identifies increased phosphorylation of NKCC2 on S126 as a hitherto unrecognized mediator of enhanced Na ( + ) reabsorption in obesity and identifies a new *role* for in regulating the activity of [SPAK/OSR1] . Regulation OSR1 PRKAG1 24808538 2944746 Activation of the with no lysine kinase/SPAK/OSR1 pathway with low-NaCl solution invoked a greater elevation in phospho-SPAK/phospho-OSR1 in AMPK ( -/- ) MEFs than in AMPK ( +/+ ) MEFs , consistent with a negative regulatory *effect* of on [SPAK/OSR1] phosphorylation . Regulation OSR1 PRKAG1 24808538 2944758 In conclusion , this study identifies increased phosphorylation of NKCC2 on S126 as a hitherto unrecognized mediator of enhanced Na ( + ) reabsorption in obesity and identifies a new *role* for in regulating the activity of [SPAK/OSR1] . Regulation OSR1 PRKAG2 24808538 2944747 Activation of the with no lysine kinase/SPAK/OSR1 pathway with low-NaCl solution invoked a greater elevation in phospho-SPAK/phospho-OSR1 in AMPK ( -/- ) MEFs than in AMPK ( +/+ ) MEFs , consistent with a negative regulatory *effect* of on [SPAK/OSR1] phosphorylation . Regulation OSR1 PRKAG2 24808538 2944759 In conclusion , this study identifies increased phosphorylation of NKCC2 on S126 as a hitherto unrecognized mediator of enhanced Na ( + ) reabsorption in obesity and identifies a new *role* for in regulating the activity of [SPAK/OSR1] . Regulation OSR1 RUNX2 18804520 1981225 [Odd skipped related 1] gene expression is *regulated* by and Ikzf1 transcription factors . Regulation OSR1 RUNX2 18804520 1981229 These findings indicate that [Osr1] expression is *regulated* by and Ikzf1 , which are known as master-gene of osteogenesis and hematopoiesis , respectively . Regulation OSR1 WNK1 16832045 1587593 Here we present evidence that the protein kinase *regulates* [OSR1] , SPAK , and NKCC activities . Regulation OSR1 YAP1 16313629 1486965 The widespread existence of novel Yap1p and Skn7p binding sites strongly suggest that direct binding of and Skn7p is *responsible* for activation of many more [OSR] genes than previously believed . Regulation OTUD5 IL1R2 21115691 2357906 signaling *regulates* [DUBA] expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production . Regulation OTX1 LHX4 15743880 1379142 The *regulation* of [Otx] in the anterior endoderm by and Fox factors may even be conserved with vertebrates . Regulation OTX2 LHX4 15743880 1379150 The *regulation* of [Otx] in the anterior endoderm by and Fox factors may even be conserved with vertebrates . Regulation OXA1L FAS 23567799 2848742 The *effect* of on [HSA-ligand] binding has long been studied . Regulation OXA1L FAS 24374750 2911742 Here , we show by NMR how the two most common in blood plasma - the long-chain FA , stearate ( C18 : 0 ) and medium-chain FA , myristate ( C14 : 0 ) - *affect* [metabolite-HSA] interaction . Regulation OXA1L TNF 23275201 2758080 These results suggest that the expression of [hsa-miR-26b] is *affected* by , leptin and resistin and that hsa-miR-26b may be an important mediator in regulating the obesity related insulin sensitivity and inflammatory responses . Regulation OXA1L WNT7A 23862015 2817430 Surprisingly , we also identify specific *regulation* of [hsa-miR29b] by but not by Wnt3 , a ligand for ß-catenin dependent signaling . Regulation OXTR CEBPA 16569740 1568505 IL-1beta has a biphasic effect on OTR expression in myometrial cells , and and NF-kappaB *play* synergistic roles in [OTR] promoter activation . Regulation OXTR CEBPB 16569740 1568431 *Regulation* of the human [oxytocin receptor] by nuclear factor-kappaB and . Regulation OXTR CEBPB 21734268 2494450 RELA and *play* a synergistic role in [OXTR] promoter activation . Regulation OXTR EGFR 12810550 1102583 Extracellular signal regulated kinase 1/2 activation by myometrial [oxytocin receptor] *involves* Galpha ( q ) Gbetagamma and tyrosine kinase activation . Regulation OXTR ESR1 24275011 2893157 Some of these CpG sites are located within putative binding sites of transcription factors known to *regulate* [Oxtr] expression , including and SP1 . Regulation OXTR GRK6 19423652 2106714 *Regulation* of [oxytocin receptor] responsiveness by in human myometrial smooth muscle . Regulation OXTR IL1B 11250916 793776 Transcriptional *regulation* of [oxytocin receptor] by and interleukin-6 . Regulation OXTR IL1B 16569740 1568496 The objective of this study was to examine the *effect* of on [OTR] expression and the roles of AP-1 , C/EBP , and NF-kappaB in OTR promoter function . Regulation OXTR IL1B 16569740 1568506 has a biphasic effect on OTR expression in myometrial cells , and C/EBP and NF-kappaB *play* synergistic roles in [OTR] promoter activation . Regulation OXTR IL6 10994633 733485 *Effects* of LPS and on [oxytocin receptor] in non-pregnant and pregnant rat uterus . Regulation OXTR IL6 11250916 793777 Transcriptional *regulation* of [oxytocin receptor] by interleukin-1beta and . Regulation OXTR IL6 11839503 911609 Supplementation of IL-1beta induced a statistically significant decrease in oxytocin receptor mRNA abundance , whereas , TNFalpha , LPS , or hypoxia did not significantly *affect* [oxytocin receptor] gene expression . Regulation OXTR NFKB1 16569740 1568507 IL-1beta has a biphasic effect on OTR expression in myometrial cells , and C/EBP and *play* synergistic roles in [OTR] promoter activation . Regulation OXTR NGF 9473629 486416 , cyclic AMP , and phorbol esters *regulate* [oxytocin receptor] gene transcription in SK-N-SH and MCF7 cells . Regulation OXTR PRDX2 22999795 2720116 The *effect* of ( 0.5 or 1 µM ) and andrographolide ( 15 or 30 µM ) on [OTR] expression was evaluated . Regulation OXTR PTHLH 8527507 336652 The *effects* of ISO and on [OTR] were potentiated by cortisol . Regulation OXTR RELA 16569740 1568508 IL-1beta has a biphasic effect on OTR expression in myometrial cells , and C/EBP and *play* synergistic roles in [OTR] promoter activation . Regulation OXTR RELA 21734268 2494448 Synergistic *regulation* of human [oxytocin receptor] promoter by CCAAT/ enhancer binding protein and . Regulation OXTR RELA 21734268 2494451 and CEBP beta (CEBPB) *play* a synergistic role in [OXTR] promoter activation . Regulation OXTR RELN 15949229 1421225 Availability of the reelin haploinsufficient ( +/- ) reeler mouse ( HRM ) provides a model for examining the *role* of in the development of the OT system and especially in the expression of the [OT receptor (OTR)] . Regulation OXTR RLN1 17055075 1683902 The *effect* of on the [oxytocin receptor] in human uterine smooth muscle cells . Regulation OXTR RLN2 17055075 1683903 The *effect* of on the [oxytocin receptor] in human uterine smooth muscle cells . Regulation OXTR RLN3 17055075 1683904 The *effect* of on the [oxytocin receptor] in human uterine smooth muscle cells . Regulation OXTR SP1 24275011 2893156 Some of these CpG sites are located within putative binding sites of transcription factors known to *regulate* [Oxtr] expression , including estrogen receptor a (ERa) and . Regulation P2RX1 GPR115 15144237 1280004 *regulation* of [P2X1] receptors does not involve direct channel phosphorylation . Regulation P2RX1 GPR132 15144237 1279993 *regulation* of [P2X1] receptors does not involve direct channel phosphorylation . Regulation P2RX1 GPR87 15144237 1280073 *regulation* of [P2X1] receptors does not involve direct channel phosphorylation . Regulation P2RX2 VSNL1 18922787 1977235 *Regulation* of [P2X2] receptors by the neuronal calcium sensor . Regulation P4HB TGM2 19404536 2070454 Like tissue transglutaminase , FXIII mediated [PDI] activity is *independent* of its activity and is located on the A subunit . Regulation PABPC1 IL1B 19454352 2084497 The known fungal pattern recognition receptors TLR2 and Dectin-1 regulate IL-1beta gene transcription , whereas the NLRP3 containing proinflammatory [multiprotein complex] , the NLRP3 inflammasome , *controls* caspase-1 mediated cleavage of . Regulation PADI3 JUN 18923650 1977490 Long-range enhancer associated with chromatin looping allows *regulation* of the [peptidylarginine deiminase] 3 gene in differentiated keratinocyte . Regulation PADI3 NFYA 16671893 1583545 and Sp1/Sp3 are *involved* in the transcriptional regulation of the peptidylarginine deiminase type III gene ( [PADI3] ) in human keratinocytes . Regulation PADI3 NFYB 16671893 1583546 and Sp1/Sp3 are *involved* in the transcriptional regulation of the [peptidylarginine deiminase type III] gene ( PADI3 ) in human keratinocytes . Regulation PADI3 NFYC 16671893 1583547 and Sp1/Sp3 are *involved* in the transcriptional regulation of the peptidylarginine deiminase type III gene ( [PADI3] ) in human keratinocytes . Regulation PADI3 SP1 16671893 1583543 NF-Y and are *involved* in the transcriptional regulation of the [peptidylarginine deiminase type III] gene ( PADI3 ) in human keratinocytes . Regulation PADI3 SP3 16671893 1583544 NF-Y and are *involved* in the transcriptional regulation of the peptidylarginine deiminase type III gene ( [PADI3] ) in human keratinocytes . Regulation PAEP IGFBP1 9584945 478188 We propose that [glycodelin] may have immunosuppressive properties and that may *regulate* trophoblast migration within the uterine endometrium . Regulation PAF1 ALOX5 3152458 104201 This suggests that <5-lipoxygenase> *dependent* mediators and [PAF] are involved in allergic contact dermatitis and that these mediators play only a minor role in irritant dermatitis . Regulation PAF1 ALOX5 7488299 323021 This study has examined the *effects* of a new <5-lipoxygenase> inhibitor , 6-hydroxy-2- ( 4-sulfamoylbenzylamino ) -4,5,7-trimethylbenzothiazo le hydrochloride ( CAS 120164-49-0 , E6080 ) on the release of LTC4 , LTB4 and [PAF] by human eosinophils , Eosinophils stimulated by 1 mumol/l calcium ionophore A23187 for 15 min released 37.5 +/- 2.2 ng , 2.3 +/- 0.3 ng and 4.0 +/- 0.3 pmol per 10 ( 6 ) cells of immunoreactive LTC4 , LTB4 and PAF , respectively ( mean +/- SEM , n = 4 ) . Regulation PAF1 ARSA 8107285 246010 Next , synthesized PAF from washed platelets or washed leukocytes stimulated with collagen or ONO-11113 ( STA2 ; stable analogue of thromboxane A2 ) , and the inhibiting *effects* of on the [PAF] synthesis from collagen stimulated leukocytes were examined , using a radioimmunoassay kit for PAF . Regulation PAF1 EDN2 2051719 161776 The purpose of the present series of experiments has been to analyze the functional relations between the *effect* of on renal function and glomerular and mesangial cell contraction and the production and actions of [PAF] in kidney . Regulation PAF1 F2R 10395981 627774 The *effect* of a agonist peptide ( TRAP-6 ) on the release of nitric oxide ( NO ) and [platelet activating factor (PAF)] from resting and calcium-ionophore ( A23187 ) -activated rat peritoneal mast cells ( RPMC ) was studied using a platelet aggregation bioassay . Regulation PAF1 TNF 1499148 193556 4. Furthermore , we investigated the priming *effect* of recombinant human , which is known to be one of the most important mediators in the development of ARDS , on [PAF] production induced by the calcium ionophore in neutrophils . Regulation PAF1 TNF 1846897 153387 We have further examined the *effects* of on arachidonic acid ( AA ) release , LTB4 production , and [platelet activating factor (PAF)] formation in PMN by prelabeling cells with either [ 3H ] AA or [ 3H ] lyso-PAF , priming with human rTNF-alpha , and then stimulating with the chemotactic peptide , FMLP . Regulation PAF1 TNF 3119758 80242 Synthesis of [PAF] in *response* to was also detected in rat polymorphonuclear neutrophils , but not in human tumor cells and dermal fibroblasts . Regulation PAF1 TNF 3261295 96000 About 30 % of [PAF] produced in *response* to either or IL-1 is released into the medium , whereas approximately 70 % remains cell associated . Regulation PAF1 TNF 3261295 96013 Experiments with labeled precursors show that [PAF] is synthesized de novo in *response* to . Regulation PAF1 TNF 3261295 96024 This suggests that [PAF] is synthesized by the same pathway in *response* to or IL-1 . Regulation PAF1 TNF 8488366 219199 In contrast to its effect on the AA turnover , did not *affect* the phospholipase C-stimulated production of platelet activating factor ( [PAF-acether] ) . Regulation PAF1 TNF 9187959 437088 GM-CSF production by EC was also stimulated by the combined effects of PAF and , but [PAF] alone did not *affect* GM-CSF production . Regulation PAFAH1B1 IFI27 19615744 2208885 We investigated whether , in [myelodysplastic syndromes (MDS)] , aberrant expression of miR-150/miR-221/miR-222 and their designated target mRNA molecules MYB , and c-KIT may be *involved* in insufficient haematopoiesis . Regulation PAFAH1B1 STK39 18083840 1837917 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation PAIP1 IL1B 19454352 2084488 The known fungal pattern recognition receptors TLR2 and Dectin-1 regulate IL-1beta gene transcription , whereas the NLRP3 containing proinflammatory [multiprotein complex] , the NLRP3 inflammasome , *controls* caspase-1 mediated cleavage of . Regulation PAK1 CCND1 15652748 1364331 Mechanistically , the effects of Vav1 require its GEF activity and the activation of Rac1 , [PAK1] , and NF-kappaB and *involve* upregulation . Regulation PAK1 TNF 19298660 2056101 In *response* to or IL-1alpha , [PAK1] was promptly activated , as characterized by a sequential phosphorylation , initiated at threonine-212 followed by at threonine-423 in the activation loop of the kinase , in human skin keratinocytes , dermal fibroblasts , and rat hepatic stellate cells . Regulation PAK4 TNF 23293332 2737824 *Regulation* of [P21 activated kinase-4] by progesterone and in human endometrium and its increased expression in advanced-stage endometriosis . Regulation PAK4 TNF 23293332 2737827 These findings suggest that [Pak4] is *regulated* by progesterone and in endometrial cells and that the increased expression of Pak4 might lead to the establishment and progression of endometriosis by enhanced cellular viability and invasiveness in endometrial cells . Regulation PAM TNF 8496690 219623 In addition , experiments with a range of cytokines indicated that interleukin 4 , transforming growth factor beta 1 and exhibited weaker ( but significant ) modulatory *effects* on [PAM] , and ( in the case of TNF-alpha ) amplified the effects of GM-CSF . Regulation PAPSS1 EPHB2 22833671 2670916 Because [SK1] activity and subcellular localization have been shown to be *regulated* by , we wished to investigate the effect of oncogenic Ras , a potent activator of the Raf/MEK/ERK pathway , on the activity of SK1 and sphingolipid metabolism . Regulation PAPSS1 TNF 15710602 1395747 Inhibition of the upstream caspase 8 by IETD significantly rescued *effects* on [SK1] , yet the caspase 7 inhibitor DEVD failed to have any effect , suggesting that the decline in SK1 occurs downstream of the initiator caspase but upstream of the effector caspase . Regulation PARD6A EPHB2 20728428 2318104 Here , we show that HGF stimulates rapid loss of the TJ assembly protein [Par6] from the TJ in an *dependent* manner . Regulation PARP1 EPHB2 22391342 2587496 ERK inhibitor blocked the interaction of PARP-1 with ERK1/2 , phosphorylation of PARP-1 , and poly ( ADP-ribosyl ) ation of p65 , suggesting that *dependent* phosphorylation of [PARP-1] regulates PARP-1 activity and NF-?B activation . Regulation PAWR F2R 12716374 1083720 These studies provide evidence that , in human platelets , both Galphaq and PLC-beta2 play a major role in *responses* to and [PAR4] activation , and that PLC-beta2 is required for the sustained Ca2+ rise upon thrombin activation . Regulation PAX3 FOXO1 16157701 1455857 In mice , [Pax3] and Pax7 play key roles in muscle cell development and differentiation , and *regulates* myoblast differentiation and fusion ; Regulation PAX7 FOXO1 16157701 1455858 In mice , Pax3 and [Pax7] play key roles in muscle cell development and differentiation , and *regulates* myoblast differentiation and fusion ; Regulation PAX8 TNF 10499522 647813 *regulation* of thyroid transcription factor-1 and [Pax-8] in rat thyroid FRTL-5 cells . Regulation PC CA12 9097031 422618 *Effect* of inhibition and acetoacetate on anaplerotic [pyruvate carboxylase] activity in cultured rat astrocytes . Regulation PCDHA1 PCDH19 15347688 1333929 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA1 PCDH8 15347688 1333934 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA10 PCDH19 15347688 1333940 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA10 PCDH8 15347688 1333945 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA11 PCDH19 15347688 1333951 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA11 PCDH8 15347688 1333956 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA12 PCDH19 15347688 1333962 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA12 PCDH8 15347688 1333967 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA13 PCDH19 15347688 1333973 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA13 PCDH8 15347688 1333978 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA14 PCDH19 15347688 1333918 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA14 PCDH8 15347688 1333923 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA2 PCDH19 15347688 1333984 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA2 PCDH8 15347688 1333989 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA3 PCDH19 15347688 1333995 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA3 PCDH8 15347688 1334000 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA4 PCDH19 15347688 1334006 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA4 PCDH8 15347688 1334011 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA5 PCDH19 15347688 1334017 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA5 PCDH8 15347688 1334022 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA6 PCDH19 15347688 1334028 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA6 PCDH8 15347688 1334033 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA7 PCDH19 15347688 1334039 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA7 PCDH8 15347688 1334044 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA8 PCDH19 15347688 1334050 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA8 PCDH8 15347688 1334055 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA9 PCDH19 15347688 1334061 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCDHA9 PCDH8 15347688 1334066 Interaction with *regulates* the cell surface expression of [protocadherin-alpha] . Regulation PCGF2 ID1 20697353 2335482 In this study , we examined the effect of Id1 on polycomb group ( PcG ) proteins , which are crucial epigenetic gene silencers , and found that *regulated* the expression of [Mel-18] and Bmi-1 , both of which belong to polycomb repressive complex 1 . Regulation PCK1 FOXO1 11467835 840748 Differential *regulation* of endogenous glucose-6-phosphatase and [phosphoenolpyruvate carboxykinase] gene expression by the forkhead transcription factor in H4IIE-hepatoma cells . Regulation PCK1 FOXO1 11467835 840757 The insulin responsive H4IIEC3 rat hepatoma cell line ( H4 cells ) was used in order to determine the *role* of the transcription factor in the regulation of [phosphoenolpyruvate carboxykinase] ( PEPCK ) and glucose-6-phosphatase (G6Pase) . Regulation PCK2 FOXO1 11467835 840749 Differential *regulation* of endogenous glucose-6-phosphatase and [phosphoenolpyruvate carboxykinase] gene expression by the forkhead transcription factor in H4IIE-hepatoma cells . Regulation PCK2 FOXO1 11467835 840758 The insulin responsive H4IIEC3 rat hepatoma cell line ( H4 cells ) was used in order to determine the *role* of the transcription factor in the regulation of [phosphoenolpyruvate carboxykinase] ( PEPCK ) and glucose-6-phosphatase (G6Pase) . Regulation PCNA CAPN8 1829675 161422 [Cyclin] proteolysis at micromolar free Ca2+ , is not inhibited by calpastatin , and therefore does not *involve* . Regulation PCNA CCND1 10766840 684538 binds and *regulates* the activity of [cyclin dependent kinases (CDKs)] 4 and 6 . Regulation PCNA CCND1 12401786 1025523 Our data also demonstrate that ectopic overexpression of either cyclin is sufficient to induce mitogen independent growth in human T98G and Rat-1 cells , although the *effects* of require downstream activation of [cyclin] E-CDK2 activity . Regulation PCNA CCND1 20801098 2324496 inhibits p300 dependent RUNX3 acetylation and negatively *regulates* [cyclin dependent kinase (cdk)] inhibitor p21 expression . Regulation PCNA CTGF 23959471 2920844 TR1 promotes cell proliferation and inhibits apoptosis through [cyclin] A and *regulation* in non-small cell lung cancer . Regulation PCNA EDN2 18973526 2086092 The *roles* of the receptors A and B ( ET ( A ) and ET ( B ) ) in CsA enhanced expression of [PCNA] and iNOS were examined in cultured human gingival fibroblasts pretreated with receptor antagonists , by immunocytochemistry and RT-PCR , respectively . Regulation PCNA EPHB2 11304535 819979 Here , we show that also *affects* [CDK2-cyclin] E activation by regulating the subcellular localization of CDK2 . Regulation PCNA EPHB2 15253728 1271692 Hcy- induced increases in thymidine incorporation and [PCNA] expression at 24 hours were *dependent* . Regulation PCNA EPHB2 18404517 1497306 Because FGF2 and P2 purinergic receptors are coupled to extracellular signal regulated protein kinase ( ERK ) , a key member of a signaling cascade that regulates proliferation , we also investigated the *role* of in regulating [cyclin] expression induced by FGF2 and ATP . Regulation PCNA EPHB2 18799628 1993279 Concomitant with this growth inhibition , however , [cyclin] E levels are increased in a *dependent* manner . Regulation PCNA IFI27 14517080 1147267 Remarkably , degradation of ( Kip1 ) , a negative *regulator* of both Cdk4/cyclin D and [Cdk2/cyclin] E complexes , is significantly diminished in T cells treated with HCV core upon mitogenic stimulation . Regulation PCNA IFI27 23029651 2681070 Here we review the structural features and disorder-function relationships for p21 and , two [cyclin dependent kinase (Cdk)] *regulators* involved in controlling cell division and fate . Regulation PCNA MAP2K6 18799628 1993285 Concomitant with this growth inhibition , however , [cyclin] E levels are increased in a *dependent* manner . Regulation PCNA SPHK1 17114809 1677203 We conclude that dependent Akt activation *plays* a significant role in TNF-alpha induced [cyclin] D expression and cell proliferation . Regulation PCNA TNF 14681231 1211292 Deletion of an E2F recognition site from this reporter eliminates the regulatory *effects* of both IGF-I and on [cyclin] A transcription , indicating the essential role of E2F-1 in mediating their cross-talk . Regulation PCSK9 ANXA2 24808179 2950610 In this study , we investigated the effect of silencing the expression of AnxA2 and PCSK9 in HepG2 and Huh7 cells to better define the *role* of in [PCSK9] regulation . Regulation PCSK9 ANXA2 24808179 2950613 Overall , our data revealed a plausible new *role* of in the reduction of [PCSK9] protein levels via a translational mechanism . Regulation PCSK9 APOB 17493938 1766637 Although [PCSK9] *controls* receptor ( LDLR ) levels post-transcriptionally , several questions concerning its mode of action remain unanswered . Regulation PCSK9 APOB 19601924 2162581 [PCSK9post-transcriptionally] downregulates the low-density lipoprotein receptor (LDLR) in the liver by binding to the epidermalgrowth factor-like repeat A ( EGF-A ) domain of the LDLR and thereby *controls* the level of in plasma . Regulation PCSK9 APOB 21847580 2521801 This paper investigated the *effects* of on [PCSK9] , and the molecular mechanisms of PCSK9 siRNA inhibited apoptosis induced by ox-LDL in human umbilical vein endothelial cells ( HUVECs ) , to clarify the role of PCSK9 in atherosclerogenesis . Regulation PCSK9 APOB 24122718 2875007 Our results show , for the first time , that modulation of levels by LA directly *affects* plasma [PCSK9] levels , and suggest that PCSK9 reduction is an additional benefit of LA . Regulation PCSK9 BIRC2 23085658 2690445 Given K27 linked polyubiquitination promotes lysosomal localization , the finding indicates the *acts* on both secretion of [PCSK9] and its lysosomal localization . Regulation PCSK9 COG2 25051126 2948676 Accordingly , inhibition of [PCSK9] activity has become an attractive *target* for drug development for lowering , and human monoclonal antibodies against PCSK9 , are now in late-stage clinical development . Regulation PCSK9 EGF 24103783 2863568 Characterization of the *role* of of low density lipoprotein receptor in [PCSK9] binding . Regulation PCSK9 EGF 24103783 2863572 Here , we further characterized the *role* of in binding of [PCSK9] to the LDLR . Regulation PCSK9 FURIN 21147780 2384596 In agreement with a key *role* of in regulating [PCSK9] activity in vivo , we observed an overall 26 % drop in the LDL receptor protein levels of Fur-hKO livers , likely due to the compound effects of a 35 % increase in PCSK9 mRNA levels and the loss of PCSK9 cleavage , suggesting a higher activity of PCSK9 in these mice . Regulation PCSK9 FURIN 21147780 2384598 We conclude that in hepatocytes *regulates* [PCSK9] mRNA levels and is the key in vivo inactivating protease of circulating PCSK9 . Regulation PCSK9 HGF 23327866 2733648 did not *affect* [PC-9] and H292 cell proliferation . Regulation PCSK9 HNF1A 19687008 2144377 *plays* a critical role in [PCSK9] gene transcription and regulation by the natural hypocholesterolemic compound berberine . Regulation PCSK9 HNF1A 22288532 2580236 In addition to SREBP2 , ( hepatic nuclear factor 1a ) positively *regulates* [PCSK9] gene transcription in hepatic cells through a binding site located 28 bp upstream from SRE . Regulation PCSK9 HNF1A 22426206 2577577 [Pcsk9] is *regulated* by the transcription factor , and our further detailed analyses suggest that increased mTORC1 activity leads to activation of PKCd , reduced activity of HNF4a and HNF1a , decreased PCSK9 expression , and ultimately increased hepatic LDLR protein levels , which result in decreased circulating LDL levels . Regulation PCSK9 LDLR 23690465 2801369 Our results support a scenario in which represents the main route of elimination of PCSK9 and a reciprocal regulation between these 2 proteins *controls* serum [PCSK9] levels , hepatic LDLR expression , and serum LDL levels . Regulation PCSK9 LDLR 24103783 2863569 Characterization of the *role* of EGF-A of in [PCSK9] binding . Regulation PCSK9 PTGS2 23065687 2915632 We sought to determine whether ( prostaglandin G/H synthase and cyclooxygenase ) ( PTGS2 ) ( aka COX2 ) , whose expression is also frequently increased in NSCLC , differentially *regulates* [PCSK] expression and activity between normal ( NHBE ) and NSCLC epithelial cells ( NCI-H292 , NCI-H441 , A549 ) . Regulation PCSK9 SIRT6 23974119 2850531 In this work we have discovered that , an NAD ( + ) -dependent histone deacetylase , *plays* a critical role in the regulation of the [Pcsk9] gene expression in mice . Regulation PCSK9 SORT1 24506872 2914238 Furthermore , circulating PCSK9 and sortilin were positively correlated in a human cohort of healthy individuals , suggesting that is *involved* in [PCSK9] secretion in humans . Regulation PCSK9 SREBF2 22288532 2580235 In addition to , HNF1a ( hepatic nuclear factor 1a ) positively *regulates* [PCSK9] gene transcription in hepatic cells through a binding site located 28 bp upstream from SRE . Regulation PDC FOXO1 22315317 2580520 The *role* of and PPAR transcription factors in diet mediated inhibition of [PDC] activation and carbohydrate oxidation during exercise in humans and the role of pharmacological activation of PDC in overriding these changes . Regulation PDCD1 CAPN8 10825507 696740 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Regulation PDCD1 CAPN8 18496573 1965602 ICP10PK inhibits *dependent* release of apoptosis inducing factor and [programmed cell death] in response to the toxin MPP+ . Regulation PDCD1 CLU 22358960 178199 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Regulation PDCD1 EPHB2 18077057 1861998 [Programmed cell death] and differential JNK , p38 and *response* in a prenatal acute hypoxic hypoxia model . Regulation PDCD1 FAS 10759366 683111 Fas ( lpr ) ( lpr ) and Fas ( lprcg ) ( lpr ( cg ) ) are allelic mutations of the gene that is *involved* in apoptosis or [programmed cell death] . Regulation PDCD1 FAS 11385298 821661 ( CD95 ) and Fas ligand ( FasL/CD95L ) are *involved* in [programmed cell death] and the regulation of host immune responses . Regulation PDCD1 FAS 8758891 377835 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Regulation PDCD1 IL1B 8035875 265202 Interleukin-1 beta converting enzyme ( ICE ) processes an inactive precursor to the proinflammatory cytokine , , and may *regulate* [programmed cell death] in neuronal cells . Regulation PDCD1 NGFR 11112333 757546 The *regulation* of [programmed cell death] by in a mesoderm derived tissue demonstrates the capacity of neurotrophins and their receptors to influence critical developmental processes both within and outside of the nervous system . Regulation PDCD1 TGM2 11697888 877687 activity is *involved* in polyamine induced [programmed cell death] . Regulation PDCD1 TNF 12021482 943204 The aim of our current study was to identify the *effect* of on [programmed cell death] . Regulation PDCD1 TNF 12048203 968554 Furthermore , phosphatidylinositol 3-kinase inhibitor or dominant negative AKT2 significantly enhances UV- and TNF alpha induced apoptosis , whereas expression of constitutively active AKT2 inhibits [programmed cell death] in *response* to UV and -induced apoptosis by inhibition of stress kinases and provide the first evidence that AKT inhibits stress kinase JNK through activation of the NF kappa B pathway . Regulation PDCD1 TNF 12093867 960434 Fas and the *regulate* the [programmed cell death] of lymphocytes . Regulation PDCD1 TNF 12446776 1017918 The proinflammatory cytokine *regulates* immune responses , inflammation , and [programmed cell death] ( apoptosis ) . Regulation PDCD1 TNF 24398264 2906901 In addition , previous studies have shown that is *involved* in cellular differentiation , neurogenesis and [programmed cell death] during the development of the central nervous system . Regulation PDCD1 TNF 7492776 332445 Critical *involvement* of transmembrane in endothelial [programmed cell death] mediated by ionizing radiation and bacterial endotoxin . Regulation PDCD1 TNF 8758891 377834 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Regulation PDCD10 CAPN8 10825507 696754 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Regulation PDCD10 CAPN8 18496573 1965617 ICP10PK inhibits *dependent* release of apoptosis inducing factor and [programmed cell death] in response to the toxin MPP+ . Regulation PDCD10 CLU 22358960 178200 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Regulation PDCD10 EPHB2 18077057 1862000 [Programmed cell death] and differential JNK , p38 and *response* in a prenatal acute hypoxic hypoxia model . Regulation PDCD10 FAS 10759366 683112 Fas ( lpr ) ( lpr ) and Fas ( lprcg ) ( lpr ( cg ) ) are allelic mutations of the gene that is *involved* in apoptosis or [programmed cell death] . Regulation PDCD10 FAS 11385298 821663 ( CD95 ) and Fas ligand ( FasL/CD95L ) are *involved* in [programmed cell death] and the regulation of host immune responses . Regulation PDCD10 FAS 8758891 377837 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Regulation PDCD10 IL1B 8035875 265204 Interleukin-1 beta converting enzyme ( ICE ) processes an inactive precursor to the proinflammatory cytokine , , and may *regulate* [programmed cell death] in neuronal cells . Regulation PDCD10 NGFR 11112333 757548 The *regulation* of [programmed cell death] by in a mesoderm derived tissue demonstrates the capacity of neurotrophins and their receptors to influence critical developmental processes both within and outside of the nervous system . Regulation PDCD10 TGM2 11697888 877694 activity is *involved* in polyamine induced [programmed cell death] . Regulation PDCD10 TNF 12021482 943205 The aim of our current study was to identify the *effect* of on [programmed cell death] . Regulation PDCD10 TNF 12048203 968555 Furthermore , phosphatidylinositol 3-kinase inhibitor or dominant negative AKT2 significantly enhances UV- and TNF alpha induced apoptosis , whereas expression of constitutively active AKT2 inhibits [programmed cell death] in *response* to UV and -induced apoptosis by inhibition of stress kinases and provide the first evidence that AKT inhibits stress kinase JNK through activation of the NF kappa B pathway . Regulation PDCD10 TNF 12093867 960435 Fas and the *regulate* the [programmed cell death] of lymphocytes . Regulation PDCD10 TNF 12446776 1017919 The proinflammatory cytokine *regulates* immune responses , inflammation , and [programmed cell death] ( apoptosis ) . Regulation PDCD10 TNF 24398264 2906902 In addition , previous studies have shown that is *involved* in cellular differentiation , neurogenesis and [programmed cell death] during the development of the central nervous system . Regulation PDCD10 TNF 7492776 332446 Critical *involvement* of transmembrane in endothelial [programmed cell death] mediated by ionizing radiation and bacterial endotoxin . Regulation PDCD10 TNF 8758891 377836 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Regulation PDCD11 CAPN8 10825507 696726 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Regulation PDCD11 CAPN8 18496573 1965587 ICP10PK inhibits *dependent* release of apoptosis inducing factor and [programmed cell death] in response to the toxin MPP+ . Regulation PDCD11 CLU 22358960 178198 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Regulation PDCD11 EPHB2 18077057 1861980 [Programmed cell death] and differential JNK , p38 and *response* in a prenatal acute hypoxic hypoxia model . Regulation PDCD11 FAS 10759366 683110 Fas ( lpr ) ( lpr ) and Fas ( lprcg ) ( lpr ( cg ) ) are allelic mutations of the gene that is *involved* in apoptosis or [programmed cell death] . Regulation PDCD11 FAS 11385298 821659 ( CD95 ) and Fas ligand ( FasL/CD95L ) are *involved* in [programmed cell death] and the regulation of host immune responses . Regulation PDCD11 FAS 8758891 377833 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Regulation PDCD11 IL1B 8035875 265200 Interleukin-1 beta converting enzyme ( ICE ) processes an inactive precursor to the proinflammatory cytokine , , and may *regulate* [programmed cell death] in neuronal cells . Regulation PDCD11 NGFR 11112333 757544 The *regulation* of [programmed cell death] by in a mesoderm derived tissue demonstrates the capacity of neurotrophins and their receptors to influence critical developmental processes both within and outside of the nervous system . Regulation PDCD11 TGM2 11697888 877680 activity is *involved* in polyamine induced [programmed cell death] . Regulation PDCD11 TNF 12021482 943203 The aim of our current study was to identify the *effect* of on [programmed cell death] . Regulation PDCD11 TNF 12048203 968553 Furthermore , phosphatidylinositol 3-kinase inhibitor or dominant negative AKT2 significantly enhances UV- and TNF alpha induced apoptosis , whereas expression of constitutively active AKT2 inhibits [programmed cell death] in *response* to UV and -induced apoptosis by inhibition of stress kinases and provide the first evidence that AKT inhibits stress kinase JNK through activation of the NF kappa B pathway . Regulation PDCD11 TNF 12093867 960433 Fas and the *regulate* the [programmed cell death] of lymphocytes . Regulation PDCD11 TNF 12446776 1017917 The proinflammatory cytokine *regulates* immune responses , inflammation , and [programmed cell death] ( apoptosis ) . Regulation PDCD11 TNF 24398264 2906900 In addition , previous studies have shown that is *involved* in cellular differentiation , neurogenesis and [programmed cell death] during the development of the central nervous system . Regulation PDCD11 TNF 7492776 332444 Critical *involvement* of transmembrane in endothelial [programmed cell death] mediated by ionizing radiation and bacterial endotoxin . Regulation PDCD11 TNF 8758891 377832 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Regulation PDCD2 CAPN8 10825507 696768 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Regulation PDCD2 CAPN8 18496573 1965632 ICP10PK inhibits *dependent* release of apoptosis inducing factor and [programmed cell death] in response to the toxin MPP+ . Regulation PDCD2 CLU 22358960 178201 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Regulation PDCD2 EPHB2 18077057 1862002 [Programmed cell death] and differential JNK , p38 and *response* in a prenatal acute hypoxic hypoxia model . Regulation PDCD2 FAS 10759366 683113 Fas ( lpr ) ( lpr ) and Fas ( lprcg ) ( lpr ( cg ) ) are allelic mutations of the gene that is *involved* in apoptosis or [programmed cell death] . Regulation PDCD2 FAS 11385298 821665 ( CD95 ) and Fas ligand ( FasL/CD95L ) are *involved* in [programmed cell death] and the regulation of host immune responses . Regulation PDCD2 FAS 8758891 377839 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Regulation PDCD2 IL1B 8035875 265206 Interleukin-1 beta converting enzyme ( ICE ) processes an inactive precursor to the proinflammatory cytokine , , and may *regulate* [programmed cell death] in neuronal cells . Regulation PDCD2 NGFR 11112333 757550 The *regulation* of [programmed cell death] by in a mesoderm derived tissue demonstrates the capacity of neurotrophins and their receptors to influence critical developmental processes both within and outside of the nervous system . Regulation PDCD2 TGM2 11697888 877701 activity is *involved* in polyamine induced [programmed cell death] . Regulation PDCD2 TNF 12021482 943206 The aim of our current study was to identify the *effect* of on [programmed cell death] . Regulation PDCD2 TNF 12048203 968556 Furthermore , phosphatidylinositol 3-kinase inhibitor or dominant negative AKT2 significantly enhances UV- and TNF alpha induced apoptosis , whereas expression of constitutively active AKT2 inhibits [programmed cell death] in *response* to UV and -induced apoptosis by inhibition of stress kinases and provide the first evidence that AKT inhibits stress kinase JNK through activation of the NF kappa B pathway . Regulation PDCD2 TNF 12093867 960436 Fas and the *regulate* the [programmed cell death] of lymphocytes . Regulation PDCD2 TNF 12446776 1017920 The proinflammatory cytokine *regulates* immune responses , inflammation , and [programmed cell death] ( apoptosis ) . Regulation PDCD2 TNF 24398264 2906903 In addition , previous studies have shown that is *involved* in cellular differentiation , neurogenesis and [programmed cell death] during the development of the central nervous system . Regulation PDCD2 TNF 7492776 332447 Critical *involvement* of transmembrane in endothelial [programmed cell death] mediated by ionizing radiation and bacterial endotoxin . Regulation PDCD2 TNF 8758891 377838 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Regulation PDCD4 CAPN8 10825507 696782 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Regulation PDCD4 CAPN8 18496573 1965647 ICP10PK inhibits *dependent* release of apoptosis inducing factor and [programmed cell death] in response to the toxin MPP+ . Regulation PDCD4 CLU 22358960 178202 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Regulation PDCD4 EPHB2 18077057 1862004 [Programmed cell death] and differential JNK , p38 and *response* in a prenatal acute hypoxic hypoxia model . Regulation PDCD4 FAS 10759366 683114 Fas ( lpr ) ( lpr ) and Fas ( lprcg ) ( lpr ( cg ) ) are allelic mutations of the gene that is *involved* in apoptosis or [programmed cell death] . Regulation PDCD4 FAS 11385298 821667 ( CD95 ) and Fas ligand ( FasL/CD95L ) are *involved* in [programmed cell death] and the regulation of host immune responses . Regulation PDCD4 FAS 8758891 377841 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Regulation PDCD4 IL1B 8035875 265208 Interleukin-1 beta converting enzyme ( ICE ) processes an inactive precursor to the proinflammatory cytokine , , and may *regulate* [programmed cell death] in neuronal cells . Regulation PDCD4 NGFR 11112333 757552 The *regulation* of [programmed cell death] by in a mesoderm derived tissue demonstrates the capacity of neurotrophins and their receptors to influence critical developmental processes both within and outside of the nervous system . Regulation PDCD4 TGM2 11697888 877708 activity is *involved* in polyamine induced [programmed cell death] . Regulation PDCD4 TNF 12021482 943207 The aim of our current study was to identify the *effect* of on [programmed cell death] . Regulation PDCD4 TNF 12048203 968557 Furthermore , phosphatidylinositol 3-kinase inhibitor or dominant negative AKT2 significantly enhances UV- and TNF alpha induced apoptosis , whereas expression of constitutively active AKT2 inhibits [programmed cell death] in *response* to UV and -induced apoptosis by inhibition of stress kinases and provide the first evidence that AKT inhibits stress kinase JNK through activation of the NF kappa B pathway . Regulation PDCD4 TNF 12093867 960437 Fas and the *regulate* the [programmed cell death] of lymphocytes . Regulation PDCD4 TNF 12446776 1017921 The proinflammatory cytokine *regulates* immune responses , inflammation , and [programmed cell death] ( apoptosis ) . Regulation PDCD4 TNF 24398264 2906904 In addition , previous studies have shown that is *involved* in cellular differentiation , neurogenesis and [programmed cell death] during the development of the central nervous system . Regulation PDCD4 TNF 7492776 332448 Critical *involvement* of transmembrane in endothelial [programmed cell death] mediated by ionizing radiation and bacterial endotoxin . Regulation PDCD4 TNF 8758891 377840 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Regulation PDCD5 CAPN8 10825507 696796 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Regulation PDCD5 CAPN8 18496573 1965662 ICP10PK inhibits *dependent* release of apoptosis inducing factor and [programmed cell death] in response to the toxin MPP+ . Regulation PDCD5 CLU 22358960 178203 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Regulation PDCD5 EPHB2 18077057 1862006 [Programmed cell death] and differential JNK , p38 and *response* in a prenatal acute hypoxic hypoxia model . Regulation PDCD5 FAS 10759366 683115 Fas ( lpr ) ( lpr ) and Fas ( lprcg ) ( lpr ( cg ) ) are allelic mutations of the gene that is *involved* in apoptosis or [programmed cell death] . Regulation PDCD5 FAS 11385298 821669 ( CD95 ) and Fas ligand ( FasL/CD95L ) are *involved* in [programmed cell death] and the regulation of host immune responses . Regulation PDCD5 FAS 8758891 377843 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Regulation PDCD5 IL1B 8035875 265210 Interleukin-1 beta converting enzyme ( ICE ) processes an inactive precursor to the proinflammatory cytokine , , and may *regulate* [programmed cell death] in neuronal cells . Regulation PDCD5 NGFR 11112333 757554 The *regulation* of [programmed cell death] by in a mesoderm derived tissue demonstrates the capacity of neurotrophins and their receptors to influence critical developmental processes both within and outside of the nervous system . Regulation PDCD5 TGM2 11697888 877715 activity is *involved* in polyamine induced [programmed cell death] . Regulation PDCD5 TNF 12021482 943208 The aim of our current study was to identify the *effect* of on [programmed cell death] . Regulation PDCD5 TNF 12048203 968558 Furthermore , phosphatidylinositol 3-kinase inhibitor or dominant negative AKT2 significantly enhances UV- and TNF alpha induced apoptosis , whereas expression of constitutively active AKT2 inhibits [programmed cell death] in *response* to UV and -induced apoptosis by inhibition of stress kinases and provide the first evidence that AKT inhibits stress kinase JNK through activation of the NF kappa B pathway . Regulation PDCD5 TNF 12093867 960438 Fas and the *regulate* the [programmed cell death] of lymphocytes . Regulation PDCD5 TNF 12446776 1017922 The proinflammatory cytokine *regulates* immune responses , inflammation , and [programmed cell death] ( apoptosis ) . Regulation PDCD5 TNF 24398264 2906905 In addition , previous studies have shown that is *involved* in cellular differentiation , neurogenesis and [programmed cell death] during the development of the central nervous system . Regulation PDCD5 TNF 7492776 332449 Critical *involvement* of transmembrane in endothelial [programmed cell death] mediated by ionizing radiation and bacterial endotoxin . Regulation PDCD5 TNF 8758891 377842 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Regulation PDCD6 CAPN8 10825507 696810 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Regulation PDCD6 CAPN8 18496573 1965677 ICP10PK inhibits *dependent* release of apoptosis inducing factor and [programmed cell death] in response to the toxin MPP+ . Regulation PDCD6 CLU 22358960 178204 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Regulation PDCD6 EPHB2 18077057 1862008 [Programmed cell death] and differential JNK , p38 and *response* in a prenatal acute hypoxic hypoxia model . Regulation PDCD6 FAS 10759366 683116 Fas ( lpr ) ( lpr ) and Fas ( lprcg ) ( lpr ( cg ) ) are allelic mutations of the gene that is *involved* in apoptosis or [programmed cell death] . Regulation PDCD6 FAS 11385298 821671 ( CD95 ) and Fas ligand ( FasL/CD95L ) are *involved* in [programmed cell death] and the regulation of host immune responses . Regulation PDCD6 FAS 8758891 377845 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Regulation PDCD6 IL1B 8035875 265212 Interleukin-1 beta converting enzyme ( ICE ) processes an inactive precursor to the proinflammatory cytokine , , and may *regulate* [programmed cell death] in neuronal cells . Regulation PDCD6 NGFR 11112333 757556 The *regulation* of [programmed cell death] by in a mesoderm derived tissue demonstrates the capacity of neurotrophins and their receptors to influence critical developmental processes both within and outside of the nervous system . Regulation PDCD6 TGM2 11697888 877722 activity is *involved* in polyamine induced [programmed cell death] . Regulation PDCD6 TNF 12021482 943209 The aim of our current study was to identify the *effect* of on [programmed cell death] . Regulation PDCD6 TNF 12048203 968559 Furthermore , phosphatidylinositol 3-kinase inhibitor or dominant negative AKT2 significantly enhances UV- and TNF alpha induced apoptosis , whereas expression of constitutively active AKT2 inhibits [programmed cell death] in *response* to UV and -induced apoptosis by inhibition of stress kinases and provide the first evidence that AKT inhibits stress kinase JNK through activation of the NF kappa B pathway . Regulation PDCD6 TNF 12093867 960439 Fas and the *regulate* the [programmed cell death] of lymphocytes . Regulation PDCD6 TNF 12446776 1017923 The proinflammatory cytokine *regulates* immune responses , inflammation , and [programmed cell death] ( apoptosis ) . Regulation PDCD6 TNF 24398264 2906906 In addition , previous studies have shown that is *involved* in cellular differentiation , neurogenesis and [programmed cell death] during the development of the central nervous system . Regulation PDCD6 TNF 7492776 332450 Critical *involvement* of transmembrane in endothelial [programmed cell death] mediated by ionizing radiation and bacterial endotoxin . Regulation PDCD6 TNF 8758891 377844 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Regulation PDCD7 CAPN8 10825507 696824 We tested a potential *role* for in the [programmed cell death] under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes , DNA fragmentation and death , ( 2 ) that calpain is translocated to the nucleus before DNA laddering , ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme , but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner . Regulation PDCD7 CAPN8 18496573 1965692 ICP10PK inhibits *dependent* release of apoptosis inducing factor and [programmed cell death] in response to the toxin MPP+ . Regulation PDCD7 CLU 22358960 178205 The type of DNA damage and the *role* of poly ( ADP-ribosyl ) polymerase ( ADPRP ) and in [programmed cell death] ( apoptosis ) was investigated in the following model systems : i ) rat thymocytes treated with dexamethasone ( DEX ) eitherin vitro orin vivo ; Regulation PDCD7 EPHB2 18077057 1862010 [Programmed cell death] and differential JNK , p38 and *response* in a prenatal acute hypoxic hypoxia model . Regulation PDCD7 FAS 10759366 683117 Fas ( lpr ) ( lpr ) and Fas ( lprcg ) ( lpr ( cg ) ) are allelic mutations of the gene that is *involved* in apoptosis or [programmed cell death] . Regulation PDCD7 FAS 11385298 821673 ( CD95 ) and Fas ligand ( FasL/CD95L ) are *involved* in [programmed cell death] and the regulation of host immune responses . Regulation PDCD7 FAS 8758891 377847 The *roles* of ( CD95 ) and TNF in antigen induced [programmed cell death] in T cell receptor transgenic mice . Regulation PDCD7 IL1B 8035875 265214 Interleukin-1 beta converting enzyme ( ICE ) processes an inactive precursor to the proinflammatory cytokine , , and may *regulate* [programmed cell death] in neuronal cells . Regulation PDCD7 NGFR 11112333 757558 The *regulation* of [programmed cell death] by in a mesoderm derived tissue demonstrates the capacity of neurotrophins and their receptors to influence critical developmental processes both within and outside of the nervous system . Regulation PDCD7 TGM2 11697888 877729 activity is *involved* in polyamine induced [programmed cell death] . Regulation PDCD7 TNF 12021482 943210 The aim of our current study was to identify the *effect* of on [programmed cell death] . Regulation PDCD7 TNF 12048203 968560 Furthermore , phosphatidylinositol 3-kinase inhibitor or dominant negative AKT2 significantly enhances UV- and TNF alpha induced apoptosis , whereas expression of constitutively active AKT2 inhibits [programmed cell death] in *response* to UV and -induced apoptosis by inhibition of stress kinases and provide the first evidence that AKT inhibits stress kinase JNK through activation of the NF kappa B pathway . Regulation PDCD7 TNF 12093867 960440 Fas and the *regulate* the [programmed cell death] of lymphocytes . Regulation PDCD7 TNF 12446776 1017924 The proinflammatory cytokine *regulates* immune responses , inflammation , and [programmed cell death] ( apoptosis ) . Regulation PDCD7 TNF 24398264 2906907 In addition , previous studies have shown that is *involved* in cellular differentiation , neurogenesis and [programmed cell death] during the development of the central nervous system . Regulation PDCD7 TNF 7492776 332451 Critical *involvement* of transmembrane in endothelial [programmed cell death] mediated by ionizing radiation and bacterial endotoxin . Regulation PDCD7 TNF 8758891 377846 The *roles* of Fas/APO-1 ( CD95 ) and in antigen induced [programmed cell death] in T cell receptor transgenic mice . Regulation PDE3B TNF 10677351 668089 We conclude that the lipolytic *effect* of involves the down-regulation of [PDE3B] , which is associated with increased activation of PKA , presumably owing to increased levels of cAMP . Regulation PDE3B TNF 10677351 668102 These results , which suggest that [PDE3B] is a novel *target* for long-term regulation by and cAMP , could contribute to the understanding of the mechanisms of insulin resistance . Regulation PDE4B CREB1 12065634 954523 Because chronic antidepressant treatment increases PDE4B , and not PDE4D , mRNA expression , we focused on the *regulation* of the [PDE4B2] promoter by cAMP and . Regulation PDE4B CREB1 12065634 954529 These data demonstrate that in cortical neurons , a short [PDE4B2] intronic promoter is *regulated* by , confers cAMP responsitivity and directs PDE4B2 mRNA and protein expression . Regulation PDE4B CREB3 12065634 954524 Because chronic antidepressant treatment increases PDE4B , and not PDE4D , mRNA expression , we focused on the *regulation* of the [PDE4B2] promoter by cAMP and . Regulation PDE4B CREB3 12065634 954530 These data demonstrate that in cortical neurons , a short [PDE4B2] intronic promoter is *regulated* by , confers cAMP responsitivity and directs PDE4B2 mRNA and protein expression . Regulation PDE4B CREB5 12065634 954522 Because chronic antidepressant treatment increases PDE4B , and not PDE4D , mRNA expression , we focused on the *regulation* of the [PDE4B2] promoter by cAMP and . Regulation PDE4B CREB5 12065634 954528 These data demonstrate that in cortical neurons , a short [PDE4B2] intronic promoter is *regulated* by , confers cAMP responsitivity and directs PDE4B2 mRNA and protein expression . Regulation PDE5A NPPA 17906676 1824256 [PDE-5A] is rapidly activated in *response* to stimulation and lowers intracellular cGMP levels . Regulation PDGFA F2R 11861803 917357 We characterized the relationship between CD62 expression and platelet derived growth factor ( [PDGF)(AB] ) and PDGF(BB) secretion in *response* to activating peptide ( TRAP ) . Regulation PDGFA F2R 17958740 1814935 The agonist peptide had no *effect* on cell growth and [PDGF-AB] levels . Regulation PDGFA IL1B 7747636 306509 By using inhibitors of secondary message pathways , we determined that the inhibitory *effect* of on [PDGF-AA] receptor binding and receptor tyrosyl autophosphorylation was not dependent on protein kinase A , protein kinase C , or the formation of prostaglandins . Regulation PDGFA TNF 7806621 284847 [ *Effect* of and interferon-gamma on [platelet derived growth factor (PDGF) A] and B gene expression in THP-1 monocytic cells ] . Regulation PDGFB BPI 18055828 1833404 Moreover , heparitinase also inhibited *actions* on VEGF and [PDGF-B] mRNA expression induced by H ( 2 ) O ( 2 ) . Regulation PDGFB F2R 11861803 917358 We characterized the relationship between CD62 expression and platelet derived growth factor ( [PDGF)(AB] ) and PDGF(BB) secretion in *response* to activating peptide ( TRAP ) . Regulation PDGFB F2R 17958740 1814936 The agonist peptide had no *effect* on cell growth and [PDGF-AB] levels . Regulation PDGFB MAP2K6 10753966 682519 In contrast , the inhibitor had no *effect* on the activity of the mutant [PDGF-B] promoter . Regulation PDGFB MMP28 11788425 901386 ANG II-induced chemotaxis is mediated by [PDGF-BB] and involves TGF-beta , but it is *independent* of activity . Regulation PDGFB MMP7 11788425 901401 ANG II-induced chemotaxis is mediated by [PDGF-BB] and involves TGF-beta , but it is *independent* of activity . Regulation PDGFB TNF 10912788 714129 However , *affected* neither the binding of [PDGF-BB] to cell surface receptors nor the total amount of PDGF beta-receptor in the cells , but decreased the PDGF induced in vitro kinase activity of the receptor . Regulation PDGFC EPHB2 15247255 1295847 Fibroblast growth factor-2 induction of [platelet derived growth factor-C] chain transcription in vascular smooth muscle cells is *dependent* but not JNK dependent and mediated by Egr-1 . Regulation PDGFC EPHB2 15247255 1295857 Moreover , using pharmacological inhibitors we demonstrate the critical *role* of but not JNK in FGF-2-inducible [PDGF-C] expression . Regulation PDGFC PLAT 18172073 1855838 Although is primarily *responsible* for processing [PDGF-C] in cultured cells , it constitutes a minority of the processing activity in the vitreous of experimental animals and in patients with PVR . Regulation PDK1 FOXO1 22586579 2632118 Thus , [Pdk1] *regulated* macrophage infiltration by inhibiting induced Ccr2 expression . Regulation PDK1 STK39 16251192 1489824 *Regulation* of transforming growth factor-beta signaling and [PDK1] kinase activity by physical interaction between PDK1 and receptor associated protein . Regulation PDK4 EPHB2 21852536 2468838 Overexpression of ErbB2 maintains PDH flux by suppressing [PDK4] expression in an *dependent* manner , and Erk signaling also regulates PDH flux in ECM attached cells . Regulation PDLIM7 TNF 9205097 440480 Epstein-Barr virus encoded [LMP1] and CD40 mediate IL-6 production in epithelial cells via an NF-kappaB pathway *involving* receptor associated factors . Regulation PDR PLAT 25349789 2959847 To investigate the *role* of and plasminogen activator inhibitor (PAI) in [proliferative diabetic retinopathy (PDR)] and to discuss the correlations among t-PA , PAI and vascular endothelial growth factor ( VEGF ) expressions . Regulation PDX1 FOXA1 19141476 2005900 Thus , the *regulation* of [Pdx1] expression by and Foxa2 is a key early event controlling the expansion and differentiation of the pancreatic primordia . Regulation PDX1 FOXO1 16282329 1509486 Taken together , is *involved* in the nucleocytoplasmic translocation of [PDX-1] by oxidative stress and the JNK pathway . Regulation PDX1 HBEGF 12437983 1016210 The current study has established the fact that glucose , GLP-1 , insulin , T ( 3 ) , , and TNF-alpha all positively *regulate* the [PDX1] gene promoter in pancreatic beta-cells . Regulation PDX1 TNF 12437983 1016209 The current study has established the fact that glucose , GLP-1 , insulin , T ( 3 ) , HB-EGF , and all positively *regulate* the [PDX1] gene promoter in pancreatic beta-cells . Regulation PDZK1 PPARA 18955051 1989320 Finally , we demonstrate that endogenous *regulates* [PDZK1] expression . Regulation PDZK1 SCARB1 14551195 1175493 Here we show that [PDZK1] *controls* in a tissue-specific and post-transcriptional fashion the expression of in vivo . Regulation PDZK1 SCARB1 23720744 2806796 The four PDZ ( PDZ1 to PDZ4 ) domain containing adaptor protein [PDZK1] *controls* the expression , localization , and function of the HDL receptor , type I ( SR-BI ) , in hepatocytes in vivo . Regulation PDZK1 SCARB2 23720744 2806797 The four PDZ ( PDZ1 to PDZ4 ) domain containing adaptor protein [PDZK1] *controls* the expression , localization , and function of the HDL receptor , type I ( SR-BI ) , in hepatocytes in vivo . Regulation PEA15 EDN2 9721757 528753 These results demonstrate that [PEA-15] is phosphorylated in astrocytes by CaMKII ( or a related kinase ) and by protein kinase C in *response* to . Regulation PEA15 EPHB2 12456656 1021444 In particular , [PEA-15] *regulates* the actions of the ERK MAP kinase cascade by binding to and altering its subcellular localization . Regulation PEBP1 TNF 8808758 382947 had no *effect* on the distribution of radioactivity in 1-acyl , 1-alkyl , and 1-alk-1-enyl subclasses of phosphatidylcholine , [phosphatidylethanolamine] , and triglyceride . Regulation PEBP4 TNF 8808758 382946 had no *effect* on the distribution of radioactivity in 1-acyl , 1-alkyl , and 1-alk-1-enyl subclasses of phosphatidylcholine , [phosphatidylethanolamine] , and triglyceride . Regulation PECAM1 CCL2 22641100 2632595 Surface localization of [PECAM-1] is increased in *response* to . Regulation PECAM1 EPO 21638298 2464617 *Effects* of on ICAM-1 and [PECAM-1] expressions on human umbilical vein endothelial cells subjected to oxidative stress . Regulation PECAM1 FER 12972546 1139515 These results suggest that localized on microtubules may *play* an important role in phosphorylation of [PECAM-1] , possibly through its association with p120catenin at nascent cell-cell contacts . Regulation PECAM1 IFNG 11029496 739857 We have investigated the in vivo regulatory *role* of mouse ( mIFN-gamma ) on the expression of [PECAM-1] on vascular endothelial cells during tumor angiogenesis . Regulation PECAM1 ITGA4 10438720 634996 Finally , [CD31] stimulation of eosinophils increased the adhesive function of alpha4beta1 integrin ( VLA-4 ) to its ligand fibronectin and their adhesion to IL-4 stimulated HUVECs in a *dependent* manner . Regulation PECAM1 ITGB1 10438720 634997 Finally , [CD31] stimulation of eosinophils increased the adhesive function of alpha4beta1 integrin ( VLA-4 ) to its ligand fibronectin and their adhesion to IL-4 stimulated HUVECs in a *dependent* manner . Regulation PECAM1 ITIH4 9257821 448513 Binding inhibition with mAbs suggested that the *effect* on dynamic binding involved CD38 , [CD31] , and CD49d , whereas the effect on static binding involved CD11a and CD49d . Regulation PECAM1 NFKB1 10640752 660658 Mobility shifts assays identified a specific NF-kappa B-binding element at +110/+120 , whose mutation abolished the basal promoter activity of PECAM-1 and decreased *responses* of the [PECAM-1] gene promoter . Regulation PECAM1 NFKB1 10640752 660662 These results demonstrate that can *regulate* the transcriptional activity of [PECAM-1] . Regulation PECAM1 NFKB1 18025177 1827655 In this study , we demonstrate that [PECAM-1] ligation with CD38-Fc fusion protein negatively *regulates* LPS induced proinflammatory cytokine TNF-alpha , IL-6 , and IFN-beta production by inhibiting JNK , , and IFN regulatory factor 3 activation in macrophages . Regulation PECAM1 NOTCH1 22865639 2687443 ß ( 2 ) -Integrin and differentially *regulate* CD34 ( + ) [CD31] ( + ) cell plasticity in vascular niches . Regulation PECAM1 PTPN11 20631249 2321910 We observed that the levels of PECAM-1 tyrosine phosphorylation and SHP-2 association with PECAM-1 were significantly increased in cells expressing a phosphatase-inactive SHP-2 mutant , suggesting that the level of [PECAM-1] tyrosine phosphorylation , and thus SHP-2 binding are *regulated* in part by bound , catalytically active . Regulation PECAM1 RELA 10640752 660659 Mobility shifts assays identified a specific NF-kappa B-binding element at +110/+120 , whose mutation abolished the basal promoter activity of PECAM-1 and decreased *responses* of the [PECAM-1] gene promoter . Regulation PECAM1 RELA 10640752 660663 These results demonstrate that can *regulate* the transcriptional activity of [PECAM-1] . Regulation PECAM1 RELA 18025177 1827656 In this study , we demonstrate that [PECAM-1] ligation with CD38-Fc fusion protein negatively *regulates* LPS induced proinflammatory cytokine TNF-alpha , IL-6 , and IFN-beta production by inhibiting JNK , , and IFN regulatory factor 3 activation in macrophages . Regulation PECAM1 RHOA 21866623 2473646 The *effect* of and MG132 on expression of HIF-1alpha , VEGF and [CD31] were detected by immunohistochemistry . Regulation PECAM1 SELE 7722414 301827 Antibody blocking studies of the ligands on HUVE indicated that may be partially involved in this CD18 independent PMNL migration but that ICAM-1 , VCAM-1 , [PECAM-1] , and P-selectin are not *involved* . Regulation PECAM1 SETD2 23292117 2742050 EGCG inhibited HPV-16 oncoprotein induced angiogenesis conferred by NSCLC through the inhibition of HIF-1a protein expression and *dependent* expression of VEGF , IL-8 , and [CD31] as well as activation of Akt , suggesting that HIF-1a may be a potential target of EGCG against HPV related NSCLC angiogenesis . Regulation PECAM1 TFF1 7726141 302054 Also the [CD31] immunoreactivity was *independent* of the pHER-2/neu , Ki67 antigen , p53 , ER , PR and immunodetectable expression in tumors , but correlates with that of cathepsin D ( P = .024 ) and P-gp ( P = .028 ) , which reflects the multi-drug resistance capacity of tumor cells . Regulation PECAM1 THBS1 15672414 1402466 The physiological role *plays* in modulation of [PECAM-1] expression and function during vascular development and angiogenesis remains largely unknown . Regulation PECAM1 TLR4 12091428 960150 These findings demonstrate that endotoxin induced keratitis is regulated by *dependent* expression of [PECAM-1] and MIP-2 , which are essential for recruitment of neutrophils to this site and for development of endotoxin induced stromal disease . Regulation PECAM1 TNFRSF1B 20633014 2334891 The present study investigated the *effect* of the anti-TNF-a agent on the expression of endothelial nuclear factor-?B ( NF-?B ) , angiogenic vascular endothelial growth factor ( VEGF ) , endothelial cell marker [CD31] , antiangiogenic factor thrombospondin-1 (TSP-1) , and antiapoptotic factors Bcl-2 and Bcl-xL in psoriasis . Regulation PECAM1 TP53 7726141 302055 Also the [CD31] immunoreactivity was *independent* of the pHER-2/neu , Ki67 antigen , , ER , PR and pS2 immunodetectable expression in tumors , but correlates with that of cathepsin D ( P = .024 ) and P-gp ( P = .028 ) , which reflects the multi-drug resistance capacity of tumor cells . Regulation PELI1 TLR7 22007846 2526501 The IKK related kinases are also the major protein kinases that activate [Pellino 1] in *response* to ( Toll-like receptor ) ligands that signal via the adaptors MyD88 ( myeloid differentiation primary response gene 88 ) and/or TRIF [ TIR ( Toll/IL-1 receptor ) domain containing adaptor protein inducing interferon ß ] . Regulation PENK ALOX5 8774948 344293 Evidence for the *involvement* of <5-lipoxygenase> products in the regulation of the expression of the [proenkephalin] gene in cultured astroglial cells . Regulation PENK IL1B 1478730 207513 *regulates* [proenkephalin] gene expression in astrocytes cultured from rat cortex . Regulation PENK IL1B 1478730 207516 also *regulated* a [proenkephalin-chloramphenicol] acetyltransferase fusion gene transiently transfected into astrocytes , with a dose-response similar to that active in proenkephalin mRNA . Regulation PENK IL1B 9200734 439648 The mediated *regulation* of [proenkephalin] and opioid receptor messenger RNA in primary astrocyte enriched cultures . Regulation PEPD IGFBP1 23981674 2885311 We studied the *effects* of , IGF-I , thrombin ( integrin activator ) , echistatin ( disintegrin ) , phosphatidylinositol 3-kinase inhibitor ( LY-294002 ) and ERK 1/2 inhibitors ( PD98059 and UO126 ) on [prolidase] activity , collagen biosynthesis and expression of proteins participating in pathways generated by these receptors . Regulation PER1 TNF 19625730 2112724 The early *effect* of on the clock gene [Per1] is dependent on p38 , mitogen activated protein kinase (MAPK) , and/or calcium signaling , whereas the effect on Dbp is independent of p38 MAPK , but also involves calcium signaling . Regulation PERP TP63 19353588 2120030 Differential [PERP] *regulation* by mutants provides insight into AEC pathogenesis . Regulation PET100 MAMLD1 20353275 2231462 Comparing patients with and without FDG [PET/CT] *response* , there was statistically significant difference in overall survival between the 2 groups ( median survival time , responder , 29.4 month ; non-responder , 14.2 month , Chi ( 2 ) =3.91 , p=0.048 ) . Regulation PET112 MAMLD1 20353275 2231464 Comparing patients with and without FDG [PET/CT] *response* , there was statistically significant difference in overall survival between the 2 groups ( median survival time , responder , 29.4 month ; non-responder , 14.2 month , Chi ( 2 ) =3.91 , p=0.048 ) . Regulation PET117 MAMLD1 20353275 2231463 Comparing patients with and without FDG [PET/CT] *response* , there was statistically significant difference in overall survival between the 2 groups ( median survival time , responder , 29.4 month ; non-responder , 14.2 month , Chi ( 2 ) =3.91 , p=0.048 ) . Regulation PF4 ARSA 2949396 66706 We studied the *effect* of versus placebo on B-thromboglobulin (B-TG) and [platelet factor 4 (PF4)] plasma levels and ADP induced platelet aggregation in 25 male patients with transient ischaemic attacks ( TIA ) . Regulation PFN1 SMN2 22197680 2568816 The present results suggest that in SMN depleted cells , the increase in profilin I expression and the reduction in inhibitory *action* on [profilin] could lead to reduced filamentous actin polymerization , thus decreasing cell motility . Regulation PFN2 SMN2 22197680 2568823 The present results suggest that in SMN depleted cells , the increase in profilin I expression and the reduction in inhibitory *action* on [profilin] could lead to reduced filamentous actin polymerization , thus decreasing cell motility . Regulation PFN3 SMN2 22197680 2568802 The present results suggest that in SMN depleted cells , the increase in profilin I expression and the reduction in inhibitory *action* on [profilin] could lead to reduced filamentous actin polymerization , thus decreasing cell motility . Regulation PFN4 SMN2 22197680 2568809 The present results suggest that in SMN depleted cells , the increase in profilin I expression and the reduction in inhibitory *action* on [profilin] could lead to reduced filamentous actin polymerization , thus decreasing cell motility . Regulation PGC A2M 14506912 1145008 The inhibitory *effects* of human , a major plasma proteinase inhibitor , on human pepsin and [gastricsin] were investigated . Regulation PGC ACE 9755129 535367 The *effects* of an inhibitor ( enalapril ) , two calcium channel antagonists ( nifedipine and verapamil ) , and an alpha1-receptor blocker ( doxazosin ) on renal blood flow ( RBF ) autoregulation , [Pgc] , and renal segmental resistances were therefore studied in SHR. Recordings of RBF autoregulation were done before and 30 min after intravenous infusion of the different drugs , and Pgc was thereafter measured with the stop-flow technique . Regulation PGC AKT1 12606503 1062899 *Regulation* of [PGC-1] promoter activity by and the forkhead transcription factor FKHR . Regulation PGC AKT1 21156859 2390426 In exploring the *role* of the dependent insulin signaling on [PGC-1a] gene transcription , we found that the basal Akt dependent signaling was increased in gastrocnemius of mice under HFD . Regulation PGC AKT1 22249024 2575345 Integrin dependent activation *regulates* [PGC-1] expression and fatty acid oxidation . Regulation PGC AKT1 23314346 2742333 Here , we propose a link between hibernation , a well documented response to periods of environmental stress , and reversible insulin resistance , potentially facilitated by key alterations in the signaling network , [PPAR-?/PGC-1a] *regulation* , and non coding RNA expression . Regulation PGC AKT2 21156859 2390427 In exploring the *role* of the dependent insulin signaling on [PGC-1a] gene transcription , we found that the basal Akt dependent signaling was increased in gastrocnemius of mice under HFD . Regulation PGC AKT2 23314346 2742334 Here , we propose a link between hibernation , a well documented response to periods of environmental stress , and reversible insulin resistance , potentially facilitated by key alterations in the signaling network , [PPAR-?/PGC-1a] *regulation* , and non coding RNA expression . Regulation PGC AKT3 21156859 2390428 In exploring the *role* of the dependent insulin signaling on [PGC-1a] gene transcription , we found that the basal Akt dependent signaling was increased in gastrocnemius of mice under HFD . Regulation PGC AKT3 23314346 2742335 Here , we propose a link between hibernation , a well documented response to periods of environmental stress , and reversible insulin resistance , potentially facilitated by key alterations in the signaling network , [PPAR-?/PGC-1a] *regulation* , and non coding RNA expression . Regulation PGC APOC3 20889132 2326888 Here we show that [PGC-1ß] *regulates* plasma triglyceride metabolism through stimulating expression and elevating APOC3 levels in circulation . Regulation PGC APP 24304563 2921422 Analyzing the *effect* of and its ?-secretase derived cleavage products Aß and AICD on [PGC-1a] expression showed that APP and AICD increase PGC-1a expression . Regulation PGC ATF4 22980225 2726678 *Effects* of on [PGC1a] expression in brown adipose tissue and metabolic responses to cold stress . Regulation PGC ATF4 22980225 2726680 We have shown previously that the expression of peroxisome proliferator activated receptor gamma coactivator ( PGC1a ) increases significantly in the white and brown adipose tissue of activating transcription factor 4 ( ATF4 ) global knockout mice , which suggests that is *involved* in the regulation of [PGC1a] expression . Regulation PGC ATF4 22980225 2726681 The *effects* of on [PGC1a] expression and on PGC1a promoter activity were analyzed in vivo and in vitro using mice , HIB-1B , and 293T cell line . Regulation PGC ATP5G1 18574256 1959279 Expression of PGC1 alpha and beta , coactivators required for PPARs and TR , was also decreased in kidneys of LPS treated mice , as were mitochondrial genes *regulated* by [PGC1] ( , COX5a , Idh3a , and Ndufs8 ) . Regulation PGC BACE1 23663737 2784960 Up- or downregulation of [PGC-1a] reciprocally *regulated* in vitro and in vivo . Regulation PGC BACH1 21682879 2451371 The top regulatory relationships identified by RegNetB include the regulation of RLN1 , RLN2 , by PAX4 , the *regulation* of ACPP ( PAP ) by JUN , and BACH2 , and the co-regulation of [PGC] and GDF15 by MAZ and TAF8 . Regulation PGC BACH2 21682879 2451370 The top regulatory relationships identified by RegNetB include the regulation of RLN1 , RLN2 , by PAX4 , the *regulation* of ACPP ( PAP ) by JUN , BACH1 and , and the co-regulation of [PGC] and GDF15 by MAZ and TAF8 . Regulation PGC BMP2 11401407 824437 These results suggest that [PGC] generation in the mouse embryo is *regulated* not only by extraembryonic ectoderm derived BMP4 and BMP8B , but also by endoderm derived . Regulation PGC BMP4 11401407 824438 These results suggest that [PGC] generation in the mouse embryo is *regulated* not only by extraembryonic ectoderm derived and BMP8B , but also by endoderm derived BMP2 . Regulation PGC CALM3 20799369 2318202 Using the same animal model , the present study investigated the role of *dependent* protein kinase IV ( CaMKIV ) and [PGC-1a] in delayed neuronal cell death and mitochondrial biogenesis in the hippocampus . Regulation PGC CD36 24371122 2926827 Recruitment of coactivator peroxisome proliferator activated receptor-? coactivator 1a ( PGC1a ) to activated AMPKa was also promoted , resulting in PGC-1a transcriptional activation through Sirt1 mediated deacetylation , increased recruitment of PPAR? , and up-regulation of Insig-1/2 , revealing a regulatory *role* of on [PGC-1a] signaling . Regulation PGC CNTF 8620850 354105 IL-6 and did not *affect* [PGC] . Regulation PGC ESRRA 12522104 1063978 In support of this hypothesis , adenovirus mediated delivery of small interfering RNA for ERRalpha , or of PGC-1 mutants that interact selectively with different types of nuclear receptors , shows that [PGC-1] can induce the fatty acid oxidation enzyme MCAD ( medium-chain acyl-coenzyme A dehydrogenase ) in an *dependent* manner . Regulation PGC FGF21 22302939 2551947 *regulates* [PGC-1a] and browning of white adipose tissues in adaptive thermogenesis . Regulation PGC GPI 23825378 2829011 Finally , we examined the *effects* of regulation on [PGC] proliferation and migration . Regulation PGC GPX1 23050972 2685048 [PGC-1a] also *regulates* cellular oxidant-antioxidant homeostasis by stimulating the gene expression of superoxide dismutase-2 (SOD2) , catalase , , and uncoupling protein (UCP) . Regulation PGC HDAC1 23564453 2789121 Transcriptional and translational regulation of protein complexes *controls* different levels of p53 , SIRT1 , and [PGC1a] proteins at the early and late stages of liver cancer . Regulation PGC HMOX1 23839791 2915944 The beneficial *effect* of induction results from an increase in PPARa and FGF21 levels and a decrease in [PGC1a] , levels they were reversed by SnMP . Regulation PGC IDH3A 18574256 1959277 Expression of PGC1 alpha and beta , coactivators required for PPARs and TR , was also decreased in kidneys of LPS treated mice , as were mitochondrial genes *regulated* by [PGC1] ( Atp5g1 , COX5a , , and Ndufs8 ) . Regulation PGC IL4 16814729 1580851 We show here that in *response* to , signal transducer and activator of transcription 6 ( STAT6 ) and [PPARgamma-coactivator-1beta (PGC-1beta)] induce macrophage programs for fatty acid oxidation and mitochondrial biogenesis . Regulation PGC IL6 8620850 354106 and CNTF did not *affect* [PGC] . Regulation PGC INS 12606503 1062900 Here , we show that forkhead transcription factor FKHR contributes to mediating the *effects* of on [PGC-1] promoter activity . Regulation PGC INS 21156859 2390429 In exploring the *role* of the Akt dependent signaling on [PGC-1a] gene transcription , we found that the basal Akt dependent signaling was increased in gastrocnemius of mice under HFD . Regulation PGC KAT2A 21888529 2491583 Further research examining exercise mediated activation of SIRT1 and the *role* of in regulating [PGC-1a] transcriptional activity in skeletal muscle is required . Regulation PGC KSR1 21518958 2434991 *regulates* [PGC1a] and estrogen related receptor a to promote oncogenic Ras dependent anchorage independent growth . Regulation PGC MAPK1 11481440 843680 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Regulation PGC MAPK1 21156859 2390350 To determine whether p38 *plays* an inhibitory or stimulatory role in [PGC-1a] gene transcription , we further investigated the role of p38 MAPK in this study . Regulation PGC MAPK10 11481440 843681 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Regulation PGC MAPK10 21156859 2390351 To determine whether p38 *plays* an inhibitory or stimulatory role in [PGC-1a] gene transcription , we further investigated the role of p38 MAPK in this study . Regulation PGC MAPK11 11481440 843682 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Regulation PGC MAPK11 21156859 2390352 To determine whether p38 *plays* an inhibitory or stimulatory role in [PGC-1a] gene transcription , we further investigated the role of p38 MAPK in this study . Regulation PGC MAPK12 11481440 843683 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Regulation PGC MAPK12 21156859 2390353 To determine whether p38 *plays* an inhibitory or stimulatory role in [PGC-1a] gene transcription , we further investigated the role of p38 MAPK in this study . Regulation PGC MAPK13 11481440 843684 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Regulation PGC MAPK13 21156859 2390354 To determine whether p38 *plays* an inhibitory or stimulatory role in [PGC-1a] gene transcription , we further investigated the role of p38 MAPK in this study . Regulation PGC MAPK14 11481440 843685 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Regulation PGC MAPK14 21156859 2390355 To determine whether p38 *plays* an inhibitory or stimulatory role in [PGC-1a] gene transcription , we further investigated the role of p38 MAPK in this study . Regulation PGC MAPK15 11481440 843679 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Regulation PGC MAPK15 21156859 2390349 To determine whether p38 *plays* an inhibitory or stimulatory role in [PGC-1a] gene transcription , we further investigated the role of p38 MAPK in this study . Regulation PGC MAPK3 11481440 843686 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Regulation PGC MAPK3 21156859 2390356 To determine whether p38 *plays* an inhibitory or stimulatory role in [PGC-1a] gene transcription , we further investigated the role of p38 MAPK in this study . Regulation PGC MAPK4 11481440 843687 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Regulation PGC MAPK4 21156859 2390357 To determine whether p38 *plays* an inhibitory or stimulatory role in [PGC-1a] gene transcription , we further investigated the role of p38 MAPK in this study . Regulation PGC MAPK6 11481440 843688 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Regulation PGC MAPK6 21156859 2390358 To determine whether p38 *plays* an inhibitory or stimulatory role in [PGC-1a] gene transcription , we further investigated the role of p38 MAPK in this study . Regulation PGC MAPK7 11481440 843689 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Regulation PGC MAPK7 21156859 2390359 To determine whether p38 *plays* an inhibitory or stimulatory role in [PGC-1a] gene transcription , we further investigated the role of p38 MAPK in this study . Regulation PGC MAPK8 11481440 843690 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Regulation PGC MAPK8 21156859 2390360 To determine whether p38 *plays* an inhibitory or stimulatory role in [PGC-1a] gene transcription , we further investigated the role of p38 MAPK in this study . Regulation PGC MAPK9 11481440 843691 We also provide evidence that interaction of the repressor with [PGC-1] is *regulated* by signaling . Regulation PGC MAPK9 21156859 2390361 To determine whether p38 *plays* an inhibitory or stimulatory role in [PGC-1a] gene transcription , we further investigated the role of p38 MAPK in this study . Regulation PGC MFN1 21160733 2356560 Based on the effect of healthy mitochondria produced by mitochondrial biogenesis on decreasing ROS mediated cell death and the recent finding that the regulation of [PGC-1] *involves* mitochondrial fusion related protein ( ) , we thus infer the regulatory role of mitochondrial fusion/fission balance in AST pathophysiology . Regulation PGC MFN2 21160733 2356559 Based on the effect of healthy mitochondria produced by mitochondrial biogenesis on decreasing ROS mediated cell death and the recent finding that the regulation of [PGC-1] *involves* mitochondrial fusion related protein ( ) , we thus infer the regulatory role of mitochondrial fusion/fission balance in AST pathophysiology . Regulation PGC MT2A 24949658 2952341 d ( 9 ) -THC also blocked the PVH *effect* of on ( 14 ) C-bromopalmitate uptake as well as on [Pgc1a] and Dio2 expression in iBAT . Regulation PGC NDUFS8 18574256 1959278 Expression of PGC1 alpha and beta , coactivators required for PPARs and TR , was also decreased in kidneys of LPS treated mice , as were mitochondrial genes *regulated* by [PGC1] ( Atp5g1 , COX5a , Idh3a , and ) . Regulation PGC NQO1 23648480 2795907 The protein level of [PGC-1a] , a key metabolic regulator , is *controlled* by . Regulation PGC NR5A2 23471216 2760766 These results indicate that the expression of human is regulated in a tissue-specific manner , and that the novel promoter region is *controlled* by the Sp-family , NR5A-family and [PGC-1a] in ovarian granulosa cells in a coordinated fashion . Regulation PGC PIM3 21187426 2378914 We identify an important *role* for in modulating c-Myc and [PGC-1a] protein levels and cell growth . Regulation PGC PPP3CA 12972445 1185617 This suggests that calcineurin may be activated by exercise in humans and does not exclude that could *play* a role in [PGC-1] transcription activation in human skeletal muscle . Regulation PGC PPP3CA 21945104 2554961 Whether can *control* [PGC-1a] expression has been proposed but is still controversial . Regulation PGC PPP3CA 21945104 2554967 Taken together , our results show that , in weight bearing skeletal muscles , basal [PGC-1a] expression , necessary to maintain slow-oxidative phenotype , is *independent* of activity . Regulation PGC PPP3CB 21945104 2554962 Whether can *control* [PGC-1a] expression has been proposed but is still controversial . Regulation PGC PPP3CC 21945104 2554963 Whether can *control* [PGC-1a] expression has been proposed but is still controversial . Regulation PGC PPP3R1 12972445 1185618 This suggests that calcineurin may be activated by exercise in humans and does not exclude that could *play* a role in [PGC-1] transcription activation in human skeletal muscle . Regulation PGC PPP3R1 21945104 2554968 Taken together , our results show that , in weight bearing skeletal muscles , basal [PGC-1a] expression , necessary to maintain slow-oxidative phenotype , is *independent* of activity . Regulation PGC PRKAA1 16352671 1539645 We compared AMPK and ACC phosphorylation and the protein content of the upstream AMPK kinase LKB1 and the *regulated* transcriptional coactivator [PPARgamma coactivator-1 (PGC-1)] in gastrocnemius of sedentary obese Zucker rats and sedentary lean Zucker rats . Regulation PGC PRKAA1 20643772 2316876 Nitric oxide and cooperatively *regulate* [PGC-1] in skeletal muscle cells . Regulation PGC PRKAA1 23297307 2752474 These data suggest that exercise causes translocation of [PGC-1a] preferentially to SS mitochondria in an *dependent* manner . Regulation PGC PRKAA1 23963743 2916046 The purpose of the present investigation was to evaluate the *role* of in regulating [PGC-1a] and mitochondrial enzymes in mouse epididymal and inguinal subcutaneous adipose tissue . Regulation PGC PRKAA1 23963743 2916058 Norepinephrine- and CL 316,243 mediated induction of [PGC-1a] and mitochondrial protein expression is *regulated* by in epididymal , but not inguinal adipose tissue . Regulation PGC PRKAA2 16352671 1539646 We compared AMPK and ACC phosphorylation and the protein content of the upstream AMPK kinase LKB1 and the *regulated* transcriptional coactivator [PPARgamma coactivator-1 (PGC-1)] in gastrocnemius of sedentary obese Zucker rats and sedentary lean Zucker rats . Regulation PGC PRKAA2 20643772 2316877 Nitric oxide and cooperatively *regulate* [PGC-1] in skeletal muscle cells . Regulation PGC PRKAA2 23297307 2752475 These data suggest that exercise causes translocation of [PGC-1a] preferentially to SS mitochondria in an *dependent* manner . Regulation PGC PRKAA2 23963743 2916047 The purpose of the present investigation was to evaluate the *role* of in regulating [PGC-1a] and mitochondrial enzymes in mouse epididymal and inguinal subcutaneous adipose tissue . Regulation PGC PRKAA2 23963743 2916059 Norepinephrine- and CL 316,243 mediated induction of [PGC-1a] and mitochondrial protein expression is *regulated* by in epididymal , but not inguinal adipose tissue . Regulation PGC PRKAB1 16352671 1539647 We compared AMPK and ACC phosphorylation and the protein content of the upstream AMPK kinase LKB1 and the *regulated* transcriptional coactivator [PPARgamma coactivator-1 (PGC-1)] in gastrocnemius of sedentary obese Zucker rats and sedentary lean Zucker rats . Regulation PGC PRKAB1 20643772 2316878 Nitric oxide and cooperatively *regulate* [PGC-1] in skeletal muscle cells . Regulation PGC PRKAB1 23297307 2752476 These data suggest that exercise causes translocation of [PGC-1a] preferentially to SS mitochondria in an *dependent* manner . Regulation PGC PRKAB1 23963743 2916048 The purpose of the present investigation was to evaluate the *role* of in regulating [PGC-1a] and mitochondrial enzymes in mouse epididymal and inguinal subcutaneous adipose tissue . Regulation PGC PRKAB1 23963743 2916060 Norepinephrine- and CL 316,243 mediated induction of [PGC-1a] and mitochondrial protein expression is *regulated* by in epididymal , but not inguinal adipose tissue . Regulation PGC PRKAB2 16352671 1539648 We compared AMPK and ACC phosphorylation and the protein content of the upstream AMPK kinase LKB1 and the *regulated* transcriptional coactivator [PPARgamma coactivator-1 (PGC-1)] in gastrocnemius of sedentary obese Zucker rats and sedentary lean Zucker rats . Regulation PGC PRKAB2 20643772 2316879 Nitric oxide and cooperatively *regulate* [PGC-1] in skeletal muscle cells . Regulation PGC PRKAB2 23297307 2752477 These data suggest that exercise causes translocation of [PGC-1a] preferentially to SS mitochondria in an *dependent* manner . Regulation PGC PRKAB2 23963743 2916049 The purpose of the present investigation was to evaluate the *role* of in regulating [PGC-1a] and mitochondrial enzymes in mouse epididymal and inguinal subcutaneous adipose tissue . Regulation PGC PRKAB2 23963743 2916061 Norepinephrine- and CL 316,243 mediated induction of [PGC-1a] and mitochondrial protein expression is *regulated* by in epididymal , but not inguinal adipose tissue . Regulation PGC PRKACB 20670916 2298494 The cAMP induced inhibition of HNF-4alpha in COS-1 cells was counteracted by overexpression of the nuclear receptor coactivator PGC-1alpha , and *dependent* induction of the [PGC1A] gene in HepG2 cells seems to explain the cell specific differences . Regulation PGC PRKACG 20670916 2298495 The cAMP induced inhibition of HNF-4alpha in COS-1 cells was counteracted by overexpression of the nuclear receptor coactivator PGC-1alpha , and *dependent* induction of the [PGC1A] gene in HepG2 cells seems to explain the cell specific differences . Regulation PGC PRKAG1 16352671 1539649 We compared AMPK and ACC phosphorylation and the protein content of the upstream AMPK kinase LKB1 and the *regulated* transcriptional coactivator [PPARgamma coactivator-1 (PGC-1)] in gastrocnemius of sedentary obese Zucker rats and sedentary lean Zucker rats . Regulation PGC PRKAG1 20643772 2316880 Nitric oxide and cooperatively *regulate* [PGC-1] in skeletal muscle cells . Regulation PGC PRKAG1 23297307 2752478 These data suggest that exercise causes translocation of [PGC-1a] preferentially to SS mitochondria in an *dependent* manner . Regulation PGC PRKAG1 23963743 2916050 The purpose of the present investigation was to evaluate the *role* of in regulating [PGC-1a] and mitochondrial enzymes in mouse epididymal and inguinal subcutaneous adipose tissue . Regulation PGC PRKAG1 23963743 2916062 Norepinephrine- and CL 316,243 mediated induction of [PGC-1a] and mitochondrial protein expression is *regulated* by in epididymal , but not inguinal adipose tissue . Regulation PGC PRKAG2 16352671 1539650 We compared AMPK and ACC phosphorylation and the protein content of the upstream AMPK kinase LKB1 and the *regulated* transcriptional coactivator [PPARgamma coactivator-1 (PGC-1)] in gastrocnemius of sedentary obese Zucker rats and sedentary lean Zucker rats . Regulation PGC PRKAG2 20643772 2316881 Nitric oxide and cooperatively *regulate* [PGC-1] in skeletal muscle cells . Regulation PGC PRKAG2 23297307 2752479 These data suggest that exercise causes translocation of [PGC-1a] preferentially to SS mitochondria in an *dependent* manner . Regulation PGC PRKAG2 23963743 2916051 The purpose of the present investigation was to evaluate the *role* of in regulating [PGC-1a] and mitochondrial enzymes in mouse epididymal and inguinal subcutaneous adipose tissue . Regulation PGC PRKAG2 23963743 2916063 Norepinephrine- and CL 316,243 mediated induction of [PGC-1a] and mitochondrial protein expression is *regulated* by in epididymal , but not inguinal adipose tissue . Regulation PGC PRKAR1A 20670916 2298496 The cAMP induced inhibition of HNF-4alpha in COS-1 cells was counteracted by overexpression of the nuclear receptor coactivator PGC-1alpha , and *dependent* induction of the [PGC1A] gene in HepG2 cells seems to explain the cell specific differences . Regulation PGC PRKAR1B 20670916 2298497 The cAMP induced inhibition of HNF-4alpha in COS-1 cells was counteracted by overexpression of the nuclear receptor coactivator PGC-1alpha , and *dependent* induction of the [PGC1A] gene in HepG2 cells seems to explain the cell specific differences . Regulation PGC PRKAR2A 20670916 2298498 The cAMP induced inhibition of HNF-4alpha in COS-1 cells was counteracted by overexpression of the nuclear receptor coactivator PGC-1alpha , and *dependent* induction of the [PGC1A] gene in HepG2 cells seems to explain the cell specific differences . Regulation PGC PRKAR2B 20670916 2298499 The cAMP induced inhibition of HNF-4alpha in COS-1 cells was counteracted by overexpression of the nuclear receptor coactivator PGC-1alpha , and *dependent* induction of the [PGC1A] gene in HepG2 cells seems to explain the cell specific differences . Regulation PGC SIRT1 21888529 2491582 Further research examining exercise mediated activation of and the *role* of GCN5 in regulating [PGC-1a] transcriptional activity in skeletal muscle is required . Regulation PGC SIRT1 23874150 2817738 *Effects* of resveratrol and on [PGC-1a] activity and mitochondrial biogenesis : a reevaluation . Regulation PGC SLC2A4 11274399 797720 These data indicate that [PGC-1] is a coactivator of MEF2C and can *control* the level of endogenous gene expression in muscle . Regulation PGC SOD2 23050972 2685046 [PGC-1a] also *regulates* cellular oxidant-antioxidant homeostasis by stimulating the gene expression of , catalase , glutathione peroxidase 1 (GPx1) , and uncoupling protein (UCP) . Regulation PGC TP53 22738191 2715435 We provide the first evidence that MAO-A upregulation in the heart causes oxidative mitochondrial damage , *dependent* repression of [PGC-1a] , cardiomyocyte necrosis , and chronic ventricular dysfunction . Regulation PGC TRPV4 23021218 2679468 In particular , negatively *regulated* the expression of [PGC1a] , UCP1 , and cellular respiration . Regulation PGC TWIST1 23093952 2690819 Transcriptional Activity of [PGC-1a] and NT-PGC-1a Is Differentially *Regulated* by in Brown Fat Metabolism . Regulation PGC UCP1 23050972 2685047 [PGC-1a] also *regulates* cellular oxidant-antioxidant homeostasis by stimulating the gene expression of superoxide dismutase-2 (SOD2) , catalase , glutathione peroxidase 1 (GPx1) , and . Regulation PGD IL1B 18598759 1972273 Exogenous NO augmented COX-2 protein expression and increased COX-2 dependent [PGD] ( 2 ) generation in *response* to SCF , IL-10 , and , or antigen activation in combination with IL-10 and IL-1beta after sensitization with IgE . Regulation PGF ARSA 1807005 177142 An inhibitor against prostaglandin synthesis , acetylsalicylic acid ( ASA , 10 ( -6 ) M ) abolished BK-induced [6-keto-PGF1] alpha synthesis , whereas did not *affect* the increase in [ Ca2+ ] i. BK-induced increases in [ Ca2+ ] i and 6-keto-PGF1 alpha production occurred in a dose dependent manner and the half-maximal response was observed at the same concentration of BK ( 10 ( -7 ) M ) . Regulation PGF IL1B 12468262 1022547 Moreover , *effects* on [PGF2alpha] and P4 levels were impaired when a NOS inhibitor N ( W ) -nitro- L -arginine methyl ester ( L-NAME , 600 microM ) was added to the incubation media . Regulation PGF IL1B 14611637 1162788 In rats , PGF ( 2alpha ) and are *involved* in structural luteolysis , [PGF] ( 2alpha ) by increasing ovarian lipid peroxidation , and IL-1beta by reducing progesterone and increasing PGF ( 2alpha ) concentrations . Regulation PGF IL1B 16423868 1533937 *regulated* PGE ( 2 ) and [PGF] ( 2alpha ) production and cytokine expression require activation of cyclooxygenase-2 (COX-2) and c-Jun NH ( 2 ) -terminal kinase , as shown using specific enzyme inhibition . Regulation PGF IL1B 16556676 1562120 By contrast , with the existing known human endometrial cell lines Ishikawa and KLE , HIESC and HIEEC increase their production of [PGF2alpha] and PGE2 and cyclooxygenase (COX)-2 protein expression in *response* to . Regulation PGF IL1B 18432307 1900165 The aim of the present study was to determine the *effect* of tumor necrosis factor-alpha (TNF-alpha) , and interleukin-6 (IL-6) on [prostaglandin (PG)F] ( 2 alpha ) and PGE ( 2 ) secretion as well as cyclooxygenase-2 (COX-2) protein expression in chorioamnion collected on days 25 , 30 and 40 of pregnancy in pigs . Regulation PGF IL1B 18432307 1900169 We demonstrated the stimulatory *effect* of TNF-alpha , and/or IL-6 on [PGF] ( 2 alpha ) and PGE ( 2 ) secretion by the porcine fetal membranes . Regulation PGF IL1B 19227129 2007366 The aim of the present study was to determine the *effect* of tumor necrosis factor-alpha (TNF-alpha) , and interleukin-6 (IL-6) on [prostaglandin (PG)F2alpha] and PGE2 secretion as well as on cyclooxygenase-2 (COX-2) protein expression in maternal placenta collected on days 25 , 30 and 40 of pregnancy in pigs . Regulation PGF IL1B 9405973 470408 To determine if *affects* progesterone ( P ) and [PGF2] alpha secretion by the baboon corpus luteum ( CL ) , we microretrodialyzed the intact CL for 48 h; 12 h media ( baseline ) , 12 h with IL-1 beta ( 3 IU/h ) , 12 h media only ( post- IL-1 beta ) and 12 h with cAMP ( 5 nmol/h ) . Regulation PGF SLCO2A1 23759308 2843878 Knock down of ERK1/2 genes in LE cells reverses the inhibitory *effects* of inhibitor on release of [PGF2] ( alpha ) . Regulation PGF TNF 10775156 686506 The aims of the present study were to determine the cell types in the endometrium ( epithelial or stromal cells ) responsible for the secretion of [PGF] ( 2alpha ) in *response* to , and the intracellular mechanisms of TNFalpha action . Regulation PGF TNF 11393218 823084 To determine the physiological significance of tumor necrosis factor-alpha (TNFalpha) in the regulation of endometrial prostaglandin ( PG ) release in cattle , we investigated the *effects* of on the secretion of PGE2 and [PGF2alpha] by bovine endometrium during the estrous cycle . Regulation PGF TNF 13679315 1185646 Moreover , a specific COX-2 inhibitor ( NS-398 ; 5 nM ) blocked the stimulatory *effect* of on [PGF2alpha] production ( P < 0.05 ) . Regulation PGF TNF 13679315 1185650 The overall results indicate that the stimulatory *effect* of on [PGF2alpha] production is mediated by the up-regulation of COX-2 gene expression and suggest that one of the mechanisms of the inhibitory effect of IFNtau on luteolysis is the inhibition of TNFalpha action in PGF2alpha production in the stromal cells by the down-regulation of COX-2 gene expression stimulated by TNFalpha . Regulation PGF TNF 16534415 1536547 Gi alpha2-/- myofibroblasts from the small intestine and colon both released asymptotically equal to 50 % less arachidonate and 3- to 7-fold less PGE2 and 6-keto [PGF1alpha] in *response* to adenosine triphosphate , thrombin , , or lipopolysaccharide , in a partially cyclooxygenase (COX)-2 dependent manner . Regulation PGF TNF 17107518 1645098 A time dependent *effect* of ( 10 ng/ml ) on [PGF] ( 2alpha ) release was observed in stromal and luminal epithelial cells . Regulation PGF TNF 19227129 2007365 The *effect* of ( TNF-alpha , interleukin (IL)-1beta and IL-6 on [prostaglandins (PG)F2alpha] and E2 secretion from maternal placenta in pigs . Regulation PGF TNF 19583958 2162569 SB202190 successfully suppressed IL-6 , IL-8 , PGE2 , and [PGF2alpha] secretion in macrophage exposed AF cells in *response* to . Regulation PGP SPHK1 17316399 1699826 Here , we have investigated the *regulation* of [P-gp] transport activity by in brain endothelial cells . Regulation PGP SRGN 1348973 185835 had little *effect* on the binding of [ 3H ] -azidopine to [P-gp] . Regulation PGP TNF 15124210 1242454 The aim of this study was to investigate the *effects* of and IFN gamma on intestinal [Pgp] expression , activity , and localization in Caco-2 cells grown on filters . Regulation PGP TNF 15124210 1242460 In conclusion , our results demonstrate an inhibitory effect of and no *effect* of IFN gamma on [Pgp] transport activity using rhodamine 123 as a substrate . Regulation PGP TNF 20300455 2224064 The signaling pathway through which lipopolysaccharide (LPS) or *regulates* [P-gp] expression and activity was investigated further in the present study . Regulation PGR CCND1 20404095 2262358 *regulated* [progesterone receptor] expression through a novel estrogen- and cyclin D1-responsive enhancer in DNA encoding part of the 3 ' untranslated region of the progesterone receptor gene . Regulation PHB TNF 19710421 2144799 We examined the *effect* of , a cytokine that plays a central role in the pathogenesis of IBD , on [PHB] expression and the effect of sustained PHB expression on TNF-alpha activation of nuclear factor-kappa B (NF-kappaB) and epithelial barrier dysfunction , two hallmarks of intestinal inflammation . Regulation PHEX TNF 16890604 1597046 The aim of this study was to evaluate whether *regulates* [Phex] gene expression thus contributing to the abnormal bone metabolism observed in IBD . Regulation PHKA2 EPHB2 20688918 2322862 Additionally , H ( 2 ) O ( 2 ) induced strong Erk activation and ionomycin stimulated [Pyk2] phosphorylation was *dependent* . Regulation PHKA2 ITGB2 20805505 2318294 Thus , [PYK2] facilitates dependent CD8 T-cell *responses* and promotes CD8 T-cell short lived effector fate , suggesting that PYK2 may be an interesting therapeutic target to suppress exacerbated CD8 T-cell responses . Regulation PHLDA1 EPHB2 15037619 1251183 The , JNK , and phosphatidylinositol 3-kinase pathways were not *involved* in IGF-I induced regulation of [TDAG51] . Regulation PI3 EPHB2 11306698 804289 These results demonstrated that t-BHQ activated [PI3-kinase] and Akt , which was responsible for ARE mediated rGSTA2 induction , and that might negatively *regulate* rGSTA2 expression , whereas activation of p38 MAP kinase or of JNK by t-BHQ was not associated with the enzyme induction . Regulation PI3 FOXO1 21335550 2411098 activity is tightly *controlled* by [phosphatidylinositol 3-kinase (PI3K)] signaling , resulting in its phosphorylation and nuclear exclusion . Regulation PI3 GPR115 14980723 1214116 It has been proposed that [phosphoinositide 3-kinase (PI3K)] , one of the phosphatidylinositol kinases , can be *regulated* by as well as nerve growth factor associated receptors . Regulation PI3 GPR115 24014027 2856727 The non-catalytic subunits are assumed to be redundant adaptors for Gß? enabling mediated *regulation* of [PI3K?] . Regulation PI3 GPR132 14980723 1214105 It has been proposed that [phosphoinositide 3-kinase (PI3K)] , one of the phosphatidylinositol kinases , can be *regulated* by as well as nerve growth factor associated receptors . Regulation PI3 GPR132 24014027 2856716 The non-catalytic subunits are assumed to be redundant adaptors for Gß? enabling mediated *regulation* of [PI3K?] . Regulation PI3 GPR87 14980723 1214185 It has been proposed that [phosphoinositide 3-kinase (PI3K)] , one of the phosphatidylinositol kinases , can be *regulated* by as well as nerve growth factor associated receptors . Regulation PI3 GPR87 24014027 2856796 The non-catalytic subunits are assumed to be redundant adaptors for Gß? enabling mediated *regulation* of [PI3K?] . Regulation PI3 PECAM1 15632208 1387990 Sphingosine kinase-1 enhances endothelial cell survival through a *dependent* activation of [PI-3K/Akt] and regulation of Bcl-2 family members . Regulation PI3 S1PR3 12385647 1034916 We previously demonstrated that sphingosine 1-phosphate (S1P) induced PLD activation via the G-protein coupled receptor was *involved* in S1P induced stimulation of [PI 3-kinase] and Akt . Regulation PI3 TLR7 23979601 2850895 Both [phosphatidylinositol 3-kinase (PI3K)-Akt] and p38 mitogen activated protein kinase (MAPK) signaling pathways are activated rapidly in *response* to activation and are required to coordinate effective host responses to pathogen invasion . Regulation PI3 TNF 15115707 1279372 Coimmunoprecipitation studies established that [PI 3-kinase] , delta-PKC , and TNFR-1 formed a signal complex in *response* to . Regulation PI4KB CABP4 11020214 737820 This was a novel finding and suggests that a activates and *regulates* [PtdIns 4-kinasebeta] . Regulation PID1 TNF 20140872 2208119 To observe the changes of NYGGF4 gene expression during human preadipocyte differentiation and to explore the regulative *role* of on [NYGGF4] gene expression in matured human adipocytes . Regulation PID1 TNF 20140872 2208120 The up-regulatory *effect* of on the [NYGGF4] gene expression tended to be enhanced with the increasing concentrations and elongation of time . Regulation PID1 TNF 20140872 2208121 The regulatory *effect* of on the [NYGGF4] gene expression is of dose dependent and time correlated . Regulation PIGR IFNG 12242032 989746 In contrast , nothing is known of the *effects* of on [pIgR] gene expression in the mammary gland . Regulation PIGR IFNG 9182878 436339 Transcriptional *regulation* of the human [polymeric immunoglobulin receptor] gene by . Regulation PIGR IFNG 9649586 515372 Vitamin A is required for *regulation* of [polymeric immunoglobulin receptor (pIgR)] expression by interleukin-4 and in a human intestinal epithelial cell line . Regulation PIGR IL4 9649586 515373 Vitamin A is required for *regulation* of [polymeric immunoglobulin receptor (pIgR)] expression by and interferon-gamma in a human intestinal epithelial cell line . Regulation PIGR MAPK1 17971154 1866692 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Regulation PIGR MAPK10 17971154 1866693 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Regulation PIGR MAPK11 17971154 1866694 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Regulation PIGR MAPK12 17971154 1866695 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Regulation PIGR MAPK13 17971154 1866696 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Regulation PIGR MAPK14 17971154 1866697 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Regulation PIGR MAPK15 17971154 1866691 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Regulation PIGR MAPK3 17971154 1866698 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Regulation PIGR MAPK4 17971154 1866699 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Regulation PIGR MAPK6 17971154 1866700 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Regulation PIGR MAPK7 17971154 1866701 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Regulation PIGR MAPK8 17971154 1866702 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Regulation PIGR MAPK9 17971154 1866703 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both and phosphatidylinositol-3-kinase in HT-29 cell line . Regulation PIGR PIK3C3 17971154 1866704 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both mitogen activated protein kinase and in HT-29 cell line . Regulation PIGR PIK3R4 17971154 1866705 Tumour necrosis factor-alpha mediated human [polymeric immunoglobulin receptor] expression is *regulated* by both mitogen activated protein kinase and in HT-29 cell line . Regulation PIGR RAB3D 18171724 1875549 These data suggest that the novel localization of [pIgR] to the regulated secretory pathway of LGACs and its secretion therefrom may be *affected* by its novel interaction with . Regulation PIGR TCF12 9973374 596034 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Regulation PIGR TCF15 9973374 596035 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Regulation PIGR TCF19 9973374 596036 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Regulation PIGR TCF20 9973374 596037 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Regulation PIGR TCF21 9973374 596038 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Regulation PIGR TCF23 9973374 596042 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Regulation PIGR TCF24 9973374 596044 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Regulation PIGR TCF25 9973374 596043 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Regulation PIGR TCF3 9973374 596039 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Regulation PIGR TCF4 9973374 596040 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Regulation PIGR TCF7 9973374 596041 Our findings indicate a major *role* for the IRF-1 in regulation of the [PIGR] gene and suggest a model for regulation of important genes in the mucosal immune system by proinflammatory cytokines . Regulation PIGR TNF 1748477 172092 Additional evidence of specificity of the TNF-alpha effect on the Fc gamma IBS was that did not *affect* expression of the [polymeric immunoglobulin receptor] ( secretory component ) , whereas IFN-gamma increased it . Regulation PIK3C3 EPHB2 11445578 850502 *regulates* the hepatocyte growth factor mediated interaction of Gab1 and the [phosphatidylinositol 3-kinase] . Regulation PIK3CA CCND1 11502738 868244 Taken together , these findings demonstrate that Ang II-induced up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a p21(ras)/Raf-1/MEK/ERK dependent manner , and also *involves* [PI3K] and SHP-2 . Regulation PIK3CA EMP1 23271282 2709681 Western blotting was performed to examine the *effect* of on the [PI3K/AKT] signaling . Regulation PIK3CA EPHB2 10669726 665959 Finally , IGF mediated degradation of IRS-1 was blocked by inhibition of [phosphatidylinositol 3'-kinase] activity but was not *affected* by inhibition of , suggesting that this may represent a direct negative-feedback mechanism resulting from downstream IRS-1 signaling . Regulation PIK3CA EPHB2 11502738 868245 Taken together , these findings demonstrate that Ang II-induced cyclin D1 up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a *dependent* manner , and also involves [PI3K] and SHP-2 . Regulation PIK3CA EPHB2 11896055 944402 negatively *regulates* the epidermal growth factor mediated interaction of Gab1 and the [phosphatidylinositol 3-kinase] . Regulation PIK3CA EPHB2 15385613 1300136 Therefore , [PI3K] induces heat hyperalgesia , possibly by regulating TRPV1 activity , in an *dependent* manner . Regulation PIK3CA EPHB2 17255101 1718064 Taken together , the data indicate that p70 S6 kinase activates PAK1 and contributes to [phosphatidylinositol 3-kinase-] and mediated *regulation* of HCV RNA replication . Regulation PIK3CA F2R 11065174 746983 Thus , the PAR-1 mediated contraction is considered to be dependent on intracellular and extracellular Ca2+ , the influx of the latter being induced through activation of L-type Ca2+ channels triggered by the enhanced Na+ permeability , and that PLC and [PI3K] , in addition to PKC and TK , are involved in the mediated dual *responses* . Regulation PIK3CA GAB3 18950707 2014546 It has been shown in several model systems that family members may *regulate* both the anti-apoptotic [PI3-K/Akt] and the mitogenic Ras/MAPK pathways , still their role in B-cells have not been investigated in detail . Regulation PIK3CA HBEGF 16034135 1436443 This [PI3K] effect was *dependent* . Regulation PIK3CA IL1B 12482999 1024702 These results suggest that the mediated MUC2 gene expression and mucin secretion in NCI-H292 cells are regulated through activation of the PKC-MEK/ERK pathway , and that [PI3K] is also *involved* in the IL-1beta mediated MUC2 gene expression and mucin secretion . Regulation PIK3CA IL1B 17390080 1716185 Addition of triptolide did not suppress activation of p38 MAPK , JNK , or [PI3K] in *response* to . Regulation PIK3CA INPP4B 24288008 2926687 We further demonstrate that *regulates* [PI3K/Akt] signaling and exerts a tumor suppressor effect , impacting the proliferative , invasive , and tumorigenic capacity of melanoma cells . Regulation PIK3CA JAG1 20833210 2330865 Increased expression upon TGFß1 exposure required Smad3 signalling , and was also *regulated* by [PI3K] and ERK . Regulation PIK3CA MAP2K6 11502738 868253 Taken together , these findings demonstrate that Ang II-induced cyclin D1 up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a *dependent* manner , and also involves [PI3K] and SHP-2 . Regulation PIK3CA MAP2K6 18034335 1924472 In summary , the activation of TRPV1 by capsaicin modulates the SP release from DRG neurons via two different mechanisms , one requiring extracellular Ca2+ , the activation of [PI3K] and the IP3 dependent intracellular Ca2+ release , and the other which is independent of extracellular Ca2+ but *involves* the activation of . Regulation PIK3CA MUC16 12482999 1024697 These results suggest that the IL-1beta mediated MUC2 gene expression and secretion in NCI-H292 cells are regulated through activation of the PKC-MEK/ERK pathway , and that [PI3K] is also *involved* in the IL-1beta mediated MUC2 gene expression and mucin secretion . Regulation PIK3CA PLAU 10995743 752352 We provide evidence that the Tyk2 mediated [PI3-K] activation in *response* to is required for VSMC migration . Regulation PIK3CA RGS16 19509421 2115973 Because a substantial percentage of breast tumors have RGS16 mutations and reduced RGS16 protein expression , we investigated the link between *regulation* of [PI3K] activity by and breast cancer cell growth . Regulation PIK3CA SCIN 12771190 1100841 The adaptor protein is *involved* in regulating diverse signal transduction pathways , including the internalization of tyrosine kinase receptors via the Cbl ubiquitin ligases , and attenuating [PI3K] activity by interaction with its regulatory subunit . Regulation PIK3CA SLC1A6 18540911 1934667 The results of this study suggest that chronic ethanol exposure decreases activity and that PKC and [PI3K] may be *involved* in these effects . Regulation PIK3CA TNF 10209302 607463 We have examined the *effect* of on insulin induced glucose uptake and activations of tyrosine kinase , IRS-1 , [PI3K] and PKC in rat adipocytes . Regulation PIK3CA TNF 10464169 640334 Therefore , both [PI 3-K] and p38 MAPK signaling pathways *control* production in T cells . Regulation PIK3CA TNF 10976992 729659 In contrast , intranuclear translocation of [PI 3-K] did not occur in *response* to the proapoptotic cytokine . Regulation PIK3CA TNF 15385257 1299163 We further showed that mediated *effects* involved [PI3K] and tyrosine kinase dependent signaling via MAPK but were independent of nuclear transcription factor (NF)-kappaB activity . Regulation PIK3CG GPR115 20616072 2291610 *regulated* [PI3Kgamma] is abundantly expressed in myeloid cells and has been implicated as a promising drug target to treat various inflammatory diseases . Regulation PIK3CG GPR132 20616072 2291599 *regulated* [PI3Kgamma] is abundantly expressed in myeloid cells and has been implicated as a promising drug target to treat various inflammatory diseases . Regulation PIK3CG GPR87 20616072 2291679 *regulated* [PI3Kgamma] is abundantly expressed in myeloid cells and has been implicated as a promising drug target to treat various inflammatory diseases . Regulation PIK3R1 CCND1 11502738 868256 Taken together , these findings demonstrate that Ang II-induced up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a p21(ras)/Raf-1/MEK/ERK dependent manner , and also *involves* [PI3K] and SHP-2 . Regulation PIK3R1 EMP1 23271282 2709682 Western blotting was performed to examine the *effect* of on the [PI3K/AKT] signaling . Regulation PIK3R1 EPHB2 10669726 665960 Finally , IGF mediated degradation of IRS-1 was blocked by inhibition of [phosphatidylinositol 3'-kinase] activity but was not *affected* by inhibition of , suggesting that this may represent a direct negative-feedback mechanism resulting from downstream IRS-1 signaling . Regulation PIK3R1 EPHB2 11502738 868257 Taken together , these findings demonstrate that Ang II-induced cyclin D1 up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a *dependent* manner , and also involves [PI3K] and SHP-2 . Regulation PIK3R1 EPHB2 11896055 944403 negatively *regulates* the epidermal growth factor mediated interaction of Gab1 and the [phosphatidylinositol 3-kinase] . Regulation PIK3R1 EPHB2 15385613 1300137 Therefore , [PI3K] induces heat hyperalgesia , possibly by regulating TRPV1 activity , in an *dependent* manner . Regulation PIK3R1 EPHB2 17255101 1718065 Taken together , the data indicate that p70 S6 kinase activates PAK1 and contributes to [phosphatidylinositol 3-kinase-] and mediated *regulation* of HCV RNA replication . Regulation PIK3R1 F2R 11065174 746984 Thus , the PAR-1 mediated contraction is considered to be dependent on intracellular and extracellular Ca2+ , the influx of the latter being induced through activation of L-type Ca2+ channels triggered by the enhanced Na+ permeability , and that PLC and [PI3K] , in addition to PKC and TK , are involved in the mediated dual *responses* . Regulation PIK3R1 GAB3 18950707 2014550 It has been shown in several model systems that family members may *regulate* both the anti-apoptotic [PI3-K/Akt] and the mitogenic Ras/MAPK pathways , still their role in B-cells have not been investigated in detail . Regulation PIK3R1 HBEGF 16034135 1436444 This [PI3K] effect was *dependent* . Regulation PIK3R1 IL1B 12482999 1024718 These results suggest that the mediated MUC2 gene expression and mucin secretion in NCI-H292 cells are regulated through activation of the PKC-MEK/ERK pathway , and that [PI3K] is also *involved* in the IL-1beta mediated MUC2 gene expression and mucin secretion . Regulation PIK3R1 IL1B 17390080 1716186 Addition of triptolide did not suppress activation of p38 MAPK , JNK , or [PI3K] in *response* to . Regulation PIK3R1 INPP4B 24288008 2926688 We further demonstrate that *regulates* [PI3K/Akt] signaling and exerts a tumor suppressor effect , impacting the proliferative , invasive , and tumorigenic capacity of melanoma cells . Regulation PIK3R1 JAG1 20833210 2330866 Increased expression upon TGFß1 exposure required Smad3 signalling , and was also *regulated* by [PI3K] and ERK . Regulation PIK3R1 MAP2K6 11502738 868265 Taken together , these findings demonstrate that Ang II-induced cyclin D1 up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a *dependent* manner , and also involves [PI3K] and SHP-2 . Regulation PIK3R1 MAP2K6 18034335 1924479 In summary , the activation of TRPV1 by capsaicin modulates the SP release from DRG neurons via two different mechanisms , one requiring extracellular Ca2+ , the activation of [PI3K] and the IP3 dependent intracellular Ca2+ release , and the other which is independent of extracellular Ca2+ but *involves* the activation of . Regulation PIK3R1 MUC16 12482999 1024713 These results suggest that the IL-1beta mediated MUC2 gene expression and secretion in NCI-H292 cells are regulated through activation of the PKC-MEK/ERK pathway , and that [PI3K] is also *involved* in the IL-1beta mediated MUC2 gene expression and mucin secretion . Regulation PIK3R1 PLAU 10995743 752353 We provide evidence that the Tyk2 mediated [PI3-K] activation in *response* to is required for VSMC migration . Regulation PIK3R1 RGS16 19509421 2115974 Because a substantial percentage of breast tumors have RGS16 mutations and reduced RGS16 protein expression , we investigated the link between *regulation* of [PI3K] activity by and breast cancer cell growth . Regulation PIK3R1 SCIN 12771190 1100842 The adaptor protein is *involved* in regulating diverse signal transduction pathways , including the internalization of tyrosine kinase receptors via the Cbl ubiquitin ligases , and attenuating [PI3K] activity by interaction with its regulatory subunit . Regulation PIK3R1 SLC1A6 18540911 1934668 The results of this study suggest that chronic ethanol exposure decreases activity and that PKC and [PI3K] may be *involved* in these effects . Regulation PIK3R1 TNF 10209302 607464 We have examined the *effect* of on insulin induced glucose uptake and activations of tyrosine kinase , IRS-1 , [PI3K] and PKC in rat adipocytes . Regulation PIK3R1 TNF 10464169 640335 Therefore , both [PI 3-K] and p38 MAPK signaling pathways *control* production in T cells . Regulation PIK3R1 TNF 10976992 729660 In contrast , intranuclear translocation of [PI 3-K] did not occur in *response* to the proapoptotic cytokine . Regulation PIK3R1 TNF 15385257 1299165 We further showed that mediated *effects* involved [PI3K] and tyrosine kinase dependent signaling via MAPK but were independent of nuclear transcription factor (NF)-kappaB activity . Regulation PIK3R4 EPHB2 11445578 850503 *regulates* the hepatocyte growth factor mediated interaction of Gab1 and the [phosphatidylinositol 3-kinase] . Regulation PIM1 IFI27 22584582 2614302 During the G ( 1 ) -S transition , the activity of Cdk2 is *regulated* by its association with ( KIP1 ) , which in rodent fibroblasts undergoes phosphorylation mainly at serine 10 , threonine 187 , and C-terminal threonine 197 by KIS , Cdk2 , and [Pim] or ROCK , respectively . Regulation PINK1 FOXO1 22378780 2581762 Consistent with its mitochondria protecting role , Sir2 expression prevented the DA neuron loss of [PINK1] null mutants in a *dependent* manner . Regulation PIP KCNE1 14532114 1152238 Here we show that [PIP] ( 2 ) and intracellular MgATP *control* the activity of the potassium channel complex . Regulation PITRM1 IL1B 15715567 1374064 We investigated the *effects* of and dexamethasone ( Dex ) on the expression of matrix [metalloprotease-1] , -2 , -3 and -14 ( membrane type-1 MMP-MT1-MMP ) as well as tissue inhibitors of matrix metalloproteases ( TIMP-1 and -2 ) mRNA by trabecular cells exposed not only to normal , but also to elevated levels of hydrostatic pressure . Regulation PITRM1 TNF 8556714 347390 We have examined the *effects* of and lymphotoxin ( LT ) on gelatinase ( 72 kDa and 92 kDa ) and tissue inhibitor of [metalloprotease 1] ( TIMP1 ) secretion by human myeloblastic leukemia cells ( ML-1 ) in vitro . Regulation PKD2 GPR115 18323855 1897950 [TRPP2/TRPC1] is activated in *response* to activation and shows a pattern of single-channel conductance , amiloride sensitivity and ion permeability distinct from that of TRPP2 or TRPC1 alone . Regulation PKD2 GPR115 19244406 2093870 Functional studies in cell culture show that [TRPP2] can be activated in *response* to mechanical cues ( fluid shear stress ) and/or receptor tyrosine kinase ( RTK ) and activation at the cell surface . Regulation PKD2 GPR132 18323855 1897939 [TRPP2/TRPC1] is activated in *response* to activation and shows a pattern of single-channel conductance , amiloride sensitivity and ion permeability distinct from that of TRPP2 or TRPC1 alone . Regulation PKD2 GPR132 19244406 2093859 Functional studies in cell culture show that [TRPP2] can be activated in *response* to mechanical cues ( fluid shear stress ) and/or receptor tyrosine kinase ( RTK ) and activation at the cell surface . Regulation PKD2 GPR87 18323855 1898019 [TRPP2/TRPC1] is activated in *response* to activation and shows a pattern of single-channel conductance , amiloride sensitivity and ion permeability distinct from that of TRPP2 or TRPC1 alone . Regulation PKD2 GPR87 19244406 2093939 Functional studies in cell culture show that [TRPP2] can be activated in *response* to mechanical cues ( fluid shear stress ) and/or receptor tyrosine kinase ( RTK ) and activation at the cell surface . Regulation PKM CCND1 24316223 2899399 [PKM2] *regulates* G1-S phase transition by controlling expression . Regulation PKN1 CAPN8 20523167 2181559 [PAK1/2] is cleaved in a *dependent* manner , and calpeptin prevents this cleavage and allows a transient activation of the kinase . Regulation PKN1 EPHB2 20526801 2320126 In this study , we investigated whether *regulates* [Rac1/Pak1] signaling and is critically linked to MB cell migration . Regulation PLA2G1B ANGPT1 14584044 1187141 However , had no *effect* on VEGF induced activation of [phospholipase A(2)] or the release of arachidonic acid . Regulation PLA2G1B FUT4 2739065 114643 [ The *effect* of the protease inhibitor on [phospholipase A2] , complement , prostaglandins and prekallikrein during endotoxin shock ] . Regulation PLA2G1B FUT4 2739065 114654 This experiment was performed to investigate the *effect* of protease inhibitor on the blood pressure , [phospholipase A2] , complement 3 , CH50 , thromboxane B2 , 6-keto-PGF1 alpha and prekallikrein during endotoxin shock using 19 dogs . Regulation PLA2G1B IL1B 10438477 634835 Type II-secreted [phospholipase A(2)] ( type II-sPLA ( 2 ) ) is expressed in smooth muscle cells during atherosclerosis or in *response* to . Regulation PLA2G1B IL1B 11571275 875437 Group IIa phospholipase A(2) ( GIIa [PLA(2)] ) is released by some cells in *response* to . Regulation PLA2G1B IL1B 1793014 176133 We have investigated the *role* of recombinant human ( rIL-1 beta ) and recombinant human tumor necrosis factor alpha ( rTNF-alpha ) on [PLA2] activity , protein synthesis and eicosanoid production in bovine pulmonary artery endothelial cells . Regulation PLA2G1B IL1B 2558648 123350 *Effects* of recombinant on phospholipase A2 activity , [phospholipase A2] mRNA levels , and eicosanoid formation in rabbit chondrocytes . Regulation PLA2G1B IL1B 2558648 123351 We have investigated the *effects* of recombinant ( rIL-1 beta ) on [phospholipase A2 activity (PLA2)] , PLA2 messenger RNA levels , and eicosanoid production in rabbit chondrocytes . Regulation PLA2G1B IL1B 2801329 119968 The *effects* of recombinant ( rIL-1 beta ) , recombinant tumor necrosis factor ( rTNF alpha ) and two growth factors , basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) on [PLA2] activity and prostaglandin E2 ( PGE2 ) release were investigated using rabbit chondrocytes . Regulation PLA2G1B IL1B 8119407 250617 Insulin-like growth factors counteract the *effect* of on type II [phospholipase A2] expression and arachidonic acid release by rabbit articular chondrocytes . Regulation PLA2G1B IL1B 9208149 440915 Previously we found that the nuclear transcription factor kappa B ( NF kappa B ) is an essential component of the *dependent* upregulation of [PLA2] gene transcription . Regulation PLA2G1B MAP2K6 16098515 1448171 GABA , progesterone and zona pellucida activation of [PLA2] and *regulation* by during acrosomal exocytosis in guinea pig spermatozoa . Regulation PLA2G1B MAP2K6 16098515 1448187 Taken together , our results suggest that PLA2 plays a fundamental role in agonist stimulated exocytosis and that are *involved* in [PLA2] regulation during this process . Regulation PLA2G1B TNF 11445585 860031 Atypical lambda/iota PKC conveys 5-lipoxygenase/leukotriene B4-mediated cross-talk between [phospholipase A2s] regulating NF-kappa B activation in *response* to and interleukin-1beta . Regulation PLA2G1B TNF 1730604 181289 Treatment with dexamethasone also inhibited cytolysis by 40-50 % indicating that the CHI *dependent* , induced activation of [PLA2] is a cause , not an effect of cytolysis . Regulation PLA2G1B TNF 18191813 1876146 To find out the mechanisms underlying the TNFalpha induced release of AA , we investigated the relationship between stimulation and [PLA(2)] *regulation* with and without zVAD , an inhibitor of caspases . Regulation PLA2G1B TNF 1836009 172255 We found that both TNF alpha and sphingosine alone enhanced these enzymatic activities , and that sphingosine additively increased the *effect* of on [phospholipase A2] activity . Regulation PLA2G1B TNF 1846897 153392 We investigated these possibilities in TNF-alpha priming of PMN and report that had no direct *effect* on [PLA2] activation or metabolite formation . Regulation PLA2G1B TNF 2801329 119965 The *effects* of recombinant interleukin-1 beta ( rIL-1 beta ) , recombinant ( rTNF alpha ) and two growth factors , basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) on [PLA2] activity and prostaglandin E2 ( PGE2 ) release were investigated using rabbit chondrocytes . Regulation PLA2G1B TNF 8387428 217982 Three important classes of compounds that potently antagonise the stimulatory *effect* of IL-1 , and cAMP on Group II [PLA2] expression in mesangial cells have been identified , namely , glucocorticoids , transforming growth factors ( TGF ) type-beta and platelet derived growth factor ( PDGF ) . Regulation PLA2G1B TNF 8967783 371715 In this study we investigated the *effects* of and IL-1 alpha on [PLA2] activity in cultured murine keratinocytes . Regulation PLA2G1B TNF 9200478 439618 Endotoxin induces expression of type II phospholipase A2 in macrophages during acute lung injury in guinea pigs : *involvement* of in lipopolysaccharide induced type II [phospholipase A2] synthesis . Regulation PLA2G2A GSK3B 15527765 1332455 negatively *regulates* [group IIA phospholipase A2] expression in human aortic smooth muscle and HepG2 hepatoma cells . Regulation PLA2G2A IL1B 11571275 875438 [Group IIa phospholipase A(2)] ( GIIa PLA(2) ) is released by some cells in *response* to . Regulation PLA2G2A MAPK1 11571275 875423 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Regulation PLA2G2A MAPK10 11571275 875424 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Regulation PLA2G2A MAPK11 11571275 875425 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Regulation PLA2G2A MAPK12 11571275 875426 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Regulation PLA2G2A MAPK13 11571275 875427 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Regulation PLA2G2A MAPK14 11571275 875428 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Regulation PLA2G2A MAPK15 11571275 875422 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Regulation PLA2G2A MAPK3 11571275 875429 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Regulation PLA2G2A MAPK4 11571275 875430 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Regulation PLA2G2A MAPK6 11571275 875431 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Regulation PLA2G2A MAPK7 11571275 875432 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Regulation PLA2G2A MAPK8 11571275 875433 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Regulation PLA2G2A MAPK9 11571275 875434 p38 *regulates* [group IIa phospholipase A2] expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes . Regulation PLA2G2D TNF 17578498 1778943 Furthermore , nasal explant culture and quantitative RT-PCR techniques were used to investigate the *effect* of interleukin (IL)-1beta and on group II subfamily [sPLA(2)s] mRNA production in sinonasal mucosa . Regulation PLA2G4A EPHB2 15894894 1407866 The present research was designed to study the *involvement* of and p38 MAP-kinase in [cytosolic phospholipase A2 (cPLA2)] and NADPH-oxidase activation by angiotensin II (Ang II) in human neutrophils . Regulation PLA2G4A EPHB2 15894894 1407908 These results suggest that either or p38 MAP-kinase are *involved* in the activation of both [cPLA2] and NADPH oxidase , and that cPLA2 is required for activation of the NADPH oxidase by Ang II in human neutrophils . Regulation PLA2G4A EPHB2 18622138 1984394 TNF-alpha-induces [cPLA(2)] activation through the pathway *involving* p38 MAPK and activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Regulation PLA2G4A IL1B 10843735 700294 these cytokines apparently suppressed IL-1beta stimulated COX-2 expression and only weakly suppressed [cPLA(2)expression] in *response* to . Regulation PLA2G4A IL1B 7480804 326820 The objective of this study was to examine the expression and activity of [cytosolic phospholipase A2 (cPLA2)] in relation to prostaglandin E2 ( PGE2 ) synthesis in human amnion derived WISH cells in *response* to stimulation by . Regulation PLA2G4A IL1B 7957239 278023 In order to identify the enzymes that are linked to IL-1 mediated arachidonate availability and subsequent PGE2 production , we have investigated the *changes* in gene expression of the 85-kDa [cytosolic PLA2 (cPLA2)] , the 14-kDa secretory PLA2 ( sPLA2 ) and the two forms of cyclooxygenase in human synoviocytes after stimulation with recombinant . Regulation PLA2G4A IL1B 8224206 234767 This *effect* of on the [cPLA2] activity is inhibited by actinomycin D and cycloheximide , indicating that both transcription and translation are involved . Regulation PLA2G4A IL1B 8711133 371297 In this study , the *effect* of on [cPLA2] and PGHS-2 mRNA expression was investigated . Regulation PLA2G4A IL1B 9060638 417789 Ad infection did not inhibit [cPLA2] translocation in *response* to or platelet derived growth factor . Regulation PLA2G4A TNF 10913368 716293 Furthermore , we provide evidence that the *dependent* activation of ERK and [cPLA(2)] requires the intact death domain of TNF-R55 . Regulation PLA2G4A TNF 10913368 716295 Finally , we demonstrate that in murine fibroblasts cPLA(2) is phosphorylated in *response* to solely by ERK , but not by p38 mitogen activated protein kinase , suggesting a signaling pathway from TNF-R55 via the death domain to ERK and [cPLA(2)] . Regulation PLA2G4A TNF 12401196 1009271 Role of caspases in mediated *regulation* of [cPLA(2)] . Regulation PLA2G4A TNF 24349530 2881294 Decreased transcription of the PLA2G4A and COX2 genes in response to cPLA2a enzyme inhibition further suggest a self reinforcing effect of [cPLA2a] inhibition in *response* to . Regulation PLA2G4A TNF 9485014 488202 Both immunofluorescence microscopy and Western blotting of cell subcompartments demonstrated translocation of [cPLA2] from the cytosol to the cell membrane in *response* to . Regulation PLA2G4A TNF 9622592 511267 and growth factors had no significant *effect* on [cPLA2] mRNA expression . Regulation PLA2G6 TNF 9746498 533318 In this study , we examined the possible existence of different PLA2 isoforms and *effects* of on [iPLA2] activities . Regulation PLAA IL1B 9227468 443237 The [PLAP] mRNA levels were also *regulated* by with a similar time course . Regulation PLAGL1 ADCYAP1 19346254 2080914 In cerebellar granule cells in culture , an increase in [Lot1] expression was paralleled by inhibition of proliferation and up-regulation of the receptor , which in turn positively *regulated* Lot1 expression . Regulation PLAGL1 CDK9 16061485 1460156 In addition , cotransfection experiments indicated that the c-Fos/c-Jun is *responsible* for cAMP dependent [Lot1] transcriptional activation . Regulation PLAGL1 FOS 16061485 1460157 In addition , cotransfection experiments indicated that the heterodimer is *responsible* for cAMP dependent [Lot1] transcriptional activation . Regulation PLAGL1 IL6ST 16061485 1460158 In addition , cotransfection experiments indicated that the c-Fos/c-Jun is *responsible* for cAMP dependent [Lot1] transcriptional activation . Regulation PLAGL1 JUN 16061485 1460155 Luciferase reporter analysis and mutagenesis of the Lot1 promoter region indicated a crucial *role* of the binding site ( located at -268 bp ) in cAMP induced [Lot1] transcription . Regulation PLAGL1 JUN 16061485 1460159 In addition , cotransfection experiments indicated that the heterodimer is *responsible* for cAMP dependent [Lot1] transcriptional activation . Regulation PLAT ACE 10090351 600161 In addition , the *effects* of on plasma levels of plasminogen activator inhibitor ( PAI-1 ) and of [tissue plasminogen activator (TPA)] were studied . Regulation PLAT ACLY 16320350 1490897 The *effects* of the reactive monoclonal on the activity of [tPA] were also examined . Regulation PLAT ALB 11757833 887622 Because fibrinolytic system components have been demonstrated to play an important role in the balance of intraperitoneal generation and degradation of fibrin , we studied the *effect* of early and advanced glycated human , methylglyoxal , and 3-deoxyglucosone on the synthesis of [tissue-type plasminogen activator] ( tPA ) , as well as its specific inhibitor ( PAI-1 ) , in human peritoneal mesothelial cells ( HPMC ) . Regulation PLAT ANGPT2 21786025 2476562 Based on above results , may induced cerebral aneurysm , ischemia/infarction on brain through RAS system by down regulating the mRNA levels of MMP 2 , uPA , PAI , PPAR-A , MCSF1 and up *regulating* [tPA] and MCP-1 and ß carotene attenuates the disease condition and bring down to normal expression levels of above genes . Regulation PLAT ANXA2 15257287 1274343 Rab3D and *play* a role in regulated secretion of vWF , but not [tPA] , from endothelial cells . Regulation PLAT ANXA2 22162045 2549125 Furthermore , we demonstrated that and Galectin-1 receptors are *involved* in [tPA] signaling and inflammatory response in glial cells . Regulation PLAT APOB 10845888 700674 The relationship between [tissue plasminogen activator (tPA)] levels and the potential *regulation* by hypertriglyceridemic very low density ( HTG-VLDL ) was examined in a human umbilical vein endothelial cell ( HUVEC ) culture model system . Regulation PLAT APOB 12167592 973162 We investigated the *effects* of on PA inhibitor-1 (PAI-1) , urokinase-type PA (uPA) , and [tissue-type PA (tPA)] in relationship to protein kinase C ( PKC ) in cultured human mesangial cells ( HMC ) . Regulation PLAT APOB 12167592 973166 The stimulatory *effects* of on PAI-1 , [tPA] , and uPA gene regulation in HMC were blocked by the inhibition of PKC using GF-109203X 12 h after treatment with LDL or downregulation of PKC using phorbol myristate acetate . Regulation PLAT APOB 12167592 973172 In summary , *regulates* PAI-1 , uPA , and [tPA] in biphasic patterns in HMC , and the upregulation of PAI-1 , uPA , and tPA after long-term LDL exposure seems to be mediated by a delayed PKC activation associated with an increased PA inhibitory activity . Regulation PLAT APOB 14706215 1196326 We analyzed the *effects* of on brain capillary endothelial expression of plasminogen activator inhibitor-1 ( PAI-1 ) , [tissue-type plasminogen activator] ( tPA ) , and thrombomodulin (TM) . Regulation PLAT APOB 16037259 1437239 Using LDL of different density subclasses , [tPA] and PAI-1 release in *response* to from diabetic patients compared with control subjects did not differ when HAECs were incubated with LDLs of increasing density isolated from each subject pair . Regulation PLAT APOB 16235525 1470516 To investigate the *effect* of high density and oxidized high density lipoprotein on the synthesis of NO , the activity of NOS , and the secretion of [tPA] and PAI-1 by cultured human umbilical vein endothelial cells ( HUVEC ) . Regulation PLAT APOB 8123649 251182 We studied the *effect* of lipoprotein(a) [ Lp(a) ] , , and high-density lipoprotein ( HDL ) on [tissue plasminogen activator (TPA)] secretion from human endothelial cells . Regulation PLAT APOB 8187237 256712 *Effects* of on the binding of plasminogen to fibrin and its activation by fibrin bound [tissue-type plasminogen activator] . Regulation PLAT APOB 9672075 520075 The present study investigated the *effect* of glycated on the production of PAI-1 and [tPA] in cultured human umbilical vein ECs ( HUVECs ) . Regulation PLAT ARG1 21394642 2562063 ( 9 ) -bradykinin had no *effect* on blood flow or [tissue plasminogen activator] release . Regulation PLAT ARG1 9133614 427317 This result suggests that and Leu62 in ETIa , in addition to Arg63 , may *play* an important role in the interaction with [tPA] . Regulation PLAT ARG2 21394642 2562064 ( 9 ) -bradykinin had no *effect* on blood flow or [tissue plasminogen activator] release . Regulation PLAT ARG2 9133614 427318 This result suggests that and Leu62 in ETIa , in addition to Arg63 , may *play* an important role in the interaction with [tPA] . Regulation PLAT ASIP 8030371 263747 To examine whether the epidermal growth factor (EGF)-like domain is *involved* in the interaction of [tissue plasminogen activator (t-PA)] with platelets , we have expressed this domain in E. coli . Regulation PLAT CA2 3082371 57495 Thus , *regulation* of the production of [tissue plasminogen activator] and prostaglandin E2 occurs at multiple points in their biosynthetic pathways . Regulation PLAT CA2 9351387 461131 In this study , we investigated the *role* of and G proteins in thrombin induced acute release ( regulated secretion ) of [tissue-type plasminogen activator (TPA)] and von Willebrand factor (vWF) , using a previously described system of primary human umbilical vein endothelial cells ( HUVECs ) . Regulation PLAT CA2 9803881 544130 signals in endothelial cells *play* the key role in the release of NO , prostacyclin ( PGI2 ) , platelet activating factor (PAF) , von Willebrand factor (vWF) , [tissue plasminogen activator (tPA)] and tissue factor pathway inhibitor (TFPI) . Regulation PLAT CALCA 3017447 62080 In UMR 106-06 cells , which unlike UMR 106-01 cells show a cyclic AMP response to calcitonin , [tPA] activity was also increased in *response* to , and the effect was enhanced by IBMX . Regulation PLAT CGA 8068191 269919 In the present study , gonadotropin and *regulation* of [tPA] and PAI-1 expression in PMSG primed granulosa cells has been investigated . Regulation PLAT CGB8 8068191 269918 In the present study , gonadotropin and *regulation* of [tPA] and PAI-1 expression in PMSG primed granulosa cells has been investigated . Regulation PLAT CMC1 18854958 2013106 In similar experiments , peritoneal fluid was collected at 24 h to assess the *effects* of on [tissue plasminogen activator] activity . Regulation PLAT CMC1 18854958 2013109 did not *affect* peritoneal [tPA] activity . Regulation PLAT CMC2 18854958 2013105 In similar experiments , peritoneal fluid was collected at 24 h to assess the *effects* of on [tissue plasminogen activator] activity . Regulation PLAT CMC2 18854958 2013108 did not *affect* peritoneal [tPA] activity . Regulation PLAT CMC4 18854958 2013107 In similar experiments , peritoneal fluid was collected at 24 h to assess the *effects* of on [tissue plasminogen activator] activity . Regulation PLAT CMC4 18854958 2013110 did not *affect* peritoneal [tPA] activity . Regulation PLAT CSF2 1707693 155065 and G-CSF ( 1 ng/mL to 1 microgram/mL ) had no *effect* on the expression of either [tissue plasminogen activator (tPA)] or plasminogen activator inhibitor-1 ( PAI-1 ) by endothelial cells . Regulation PLAT CSF3 1707693 155066 GM-CSF and ( 1 ng/mL to 1 microgram/mL ) had no *effect* on the expression of either [tissue plasminogen activator (tPA)] or plasminogen activator inhibitor-1 ( PAI-1 ) by endothelial cells . Regulation PLAT EDN1 10397697 627861 The *effects* of on the production of plasminogen activator inhibitor 1 ( PAI-1 ) and [tissue plasminogen activator (t-PA)] by human brain derived endothelial cells in culture were studied . Regulation PLAT EGF 11814314 892834 We have examined expression of the components of the plasminogen activation system in human astrocytoma U373-MG cells and found that interleukin 1beta (IL-1beta) , tumour necrosis factor alpha TNF-alpha ) , interferon gamma (INF-gamma) and specifically *regulate* the expression of [tissue-type plasminogen activator (t-PA)] , urokinase-type plasminogen activator ( u-PA ) , plasminogen activator inhibitor type 1 ( PAI-1 ) and protease nexin-1 (PN-1) . Regulation PLAT EGF 2128970 150620 Under conditions in which had no *effect* on [tPA] activity , tPA antigen paradoxically increased with a concomitant rise of tPA/PAI-1 complexes . Regulation PLAT EGF 2133249 150699 We found that , under conditions in which had no *effect* on [tPA] activity , tPA antigen increased with a concomitant rise of tPA/PAI-1 complexes , indicating the action of an inhibitor . Regulation PLAT EGF 8297819 240935 *Effects* of on cell growth , DNA synthesis , and laminin , collagen IV , and [tissue plasminogen activator (t-PA)] production of human uterine cervical adenocarcinoma cell line OMC-4 were examined , together with the characteristics of its EGF receptors . Regulation PLAT F2 3137687 97304 Differential *effects* of activation of by streptokinase compared with urokinase and [tissue-type plasminogen activator (t-PA)] . Regulation PLAT FGA 6543039 44405 The potentiating *effect* of on plasminogen activation by [tissue-type plasminogen activator] is much more important with lys-plasminogen than with mini-plasminogen ( which lacks the high affinity lysine binding site important for binding to fibrin ) . Regulation PLAT FGB 12695744 1081182 The *effect* of fucoidan , heparin and cyanogen on the activation of human glutamic-plasminogen by [tissue plasminogen activator] . Regulation PLAT FGB 6543039 44406 The potentiating *effect* of on plasminogen activation by [tissue-type plasminogen activator] is much more important with lys-plasminogen than with mini-plasminogen ( which lacks the high affinity lysine binding site important for binding to fibrin ) . Regulation PLAT FGF1 11078636 749449 The *effects* of , histamine , and LPS on the presence of [tPA] and on enhancing the levels of mRNA reached maximum activity at 4 h and declined to levels below that of controls by 8 h . Regulation PLAT FGF2 1324147 194938 The antibody against human bFGF neutralized the stimulatory *effect* of on [tissue plasminogen activator] secretion . Regulation PLAT FGF2 7701477 297563 Heparin actually increased the stimulatory *effect* of on [tPA] . Regulation PLAT FGG 6543039 44407 The potentiating *effect* of on plasminogen activation by [tissue-type plasminogen activator] is much more important with lys-plasminogen than with mini-plasminogen ( which lacks the high affinity lysine binding site important for binding to fibrin ) . Regulation PLAT GIF 11814314 892835 We have examined expression of the components of the plasminogen activation system in human astrocytoma U373-MG cells and found that interleukin 1beta (IL-1beta) , tumour necrosis factor alpha TNF-alpha ) , and epidermal growth factor (EGF) specifically *regulate* the expression of [tissue-type plasminogen activator (t-PA)] , urokinase-type plasminogen activator ( u-PA ) , plasminogen activator inhibitor type 1 ( PAI-1 ) and protease nexin-1 (PN-1) . Regulation PLAT HGF 10064822 593465 These results are consistent with the hypothesis that plays a role in the development and maintenance of both the cerebral cortex and hippocampus , and that [tPA] may *act* as a regulator of HGF/SF activity in these structures . Regulation PLAT HIF1A 19490965 2149456 CHIP assay further confirmed that the induction of PAI-1 involved the binding of HIF-1alpha to the PAI-1 promoter , while the enhancement or silencing of did not *affect* the expression of urokinase type PA (uPA) , tissue [type PA (tPA)] or uPA receptor (uPAR) . Regulation PLAT HPR 10762018 683351 The preliminary results of other studies on the *effects* of <4-HPR> on [tissue plasminogen activator (t-PA)] , plasminogen activator inhibitor-1 ( PAI-1 ) , and urokinase plasminogen activator (uk-PA) and on the relevance of circulating p53 antibodies with relapse will be also presented . Regulation PLAT HSPG2 17264956 1691418 Acute [tissue-type plasminogen activator] release in human microvascular endothelial cells : the *roles* of Galphaq , , IP3 and 5,6-epoxyeicosatrienoic acid . Regulation PLAT IFNG 9124280 419502 did not significantly *affect* bFGF induction of SMC [tPA] and PAI-1 antigens . Regulation PLAT IL10 1571831 187182 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL10 9208283 440952 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL11 1571831 187183 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL11 9208283 440953 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL13 1571831 187184 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL13 9208283 440954 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL15 1571831 187185 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL15 9208283 440955 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL16 1571831 187186 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL16 9208283 440956 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL18 1571831 187187 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL18 9208283 440957 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL19 1571831 187188 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL19 9208283 440958 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL1A 11594749 870034 *regulation* of [tPA] in hepatocytes was studied in mouse hepatocyte line AML12 . Regulation PLAT IL1A 8691730 370552 We investigated the *effects* of on the production of [tissue-type plasminogen activator (t-PA)] , urokinase ( u-PA ) and PAI-1 by glomerular cells . Regulation PLAT IL1B 10743860 680566 Our previous studies had demonstrated that in inflamed gingival tissues , [tissue-type plasminogen activator (t-PA)] is significantly increased in the extracellular matrix of the connective tissue and that can up *regulate* the level of t-PA and plasminogen activator inhibitor-2 ( PAI-2 ) synthesis by human gingival fibroblasts . Regulation PLAT IL1B 11814314 892836 We have examined expression of the components of the plasminogen activation system in human astrocytoma U373-MG cells and found that , tumour necrosis factor alpha TNF-alpha ) , interferon gamma (INF-gamma) and epidermal growth factor (EGF) specifically *regulate* the expression of [tissue-type plasminogen activator (t-PA)] , urokinase-type plasminogen activator ( u-PA ) , plasminogen activator inhibitor type 1 ( PAI-1 ) and protease nexin-1 (PN-1) . Regulation PLAT IL1B 18502475 1984080 *Effects* of and IL-6 on [tissue-type plasminogen activator] expression in vascular endothelial cells . Regulation PLAT IL2 1571831 187189 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL2 3143745 100984 We studied the *effects* of natural and recombinant human ( rIL-2 ) on secretion of prostacyclin ( PGI2 ) , vWf , and [tissue-type plasminogen activator] ( tPA ) . Regulation PLAT IL2 9208283 440959 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL20 1571831 187190 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL20 9208283 440960 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL21 1571831 187191 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL21 9208283 440961 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL22 1571831 187174 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL22 9208283 440944 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL24 1571831 187172 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL24 9208283 440939 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL25 1571831 187173 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL25 9208283 440943 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL26 1571831 187178 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL26 9208283 440948 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL27 1571831 187179 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL27 9208283 440949 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL3 1571831 187192 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL3 9208283 440962 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL31 1571831 187180 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL31 9208283 440950 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL32 1571831 187177 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL32 9208283 440947 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL33 1571831 187176 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL33 9208283 440946 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL34 1571831 187181 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL34 9208283 440951 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL37 1571831 187175 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL37 9208283 440945 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL4 1571831 187193 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL4 2110990 132882 However , contrasting *effects* of and dexamethasone ( Dex ) on monocyte [tissue-type plasminogen activator (t-PA)] production suggest that these agents may operate by different pathways . Regulation PLAT IL4 7586221 333739 In order to determine whether the T-cell lymphokines interleukin-4 (IL-4) and gamma interferon ( gamma-IFN ) affect SMC fibrinolysis and migration , we examined the *effects* of human recombinant and gamma-IFN on human aortic SMC [tissue-type plasminogen activator (TPA)] , urokinase-type plasminogen activator ( UPA ) , and plasminogen activator inhibitor type-1 ( PAI-1 ) antigen production , as determined by enzyme linked immunosorbent assays . Regulation PLAT IL4 9208283 440963 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL5 1571831 187194 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL5 9208283 440964 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL6 12794725 1098331 These results suggest that can *regulate* DV-induced [tPA] production of endothelial cells , which may play important roles in the pathogenic development of DHF/DSS . Regulation PLAT IL6 1571831 187195 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL6 18502475 1984081 *Effects* of IL-1beta and on [tissue-type plasminogen activator] expression in vascular endothelial cells . Regulation PLAT IL6 9208283 440965 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL7 1571831 187196 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL7 9208283 440966 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL8 1571831 187197 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL8 9208283 440967 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT IL9 1571831 187198 *Effects* of , tumor necrosis factor -beta , and forskolin on [tissue plasminogen activator] activity in human osteoblastic osteosarcoma cells . Regulation PLAT IL9 9208283 440968 Opposing *effects* of and transforming growth factor-beta on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT INS 1905068 161540 The acute *effect* of on [tissue plasminogen activator] and plasminogen activator inhibitor in man . Regulation PLAT INS 1905068 161542 The present study was performed to elucidate the acute *effect* of on levels of [tissue plasminogen activator (t-PA)] and plasminogen activator inhibitor of endothelial cell type ( PAI-1 ) . Regulation PLAT INS 8692017 372754 In the present study , we examined if proinsulin and *affect* the constitutive ( fasting ) secretion of plasminogen activator inhibitor type 1 ( PAI-1 ) and [tissue plasminogen activator (t-PA)] in young healthy women ( N = 17 ) . Regulation PLAT JUN 18982462 2006598 We have analyzed a possible *role* of mitogen activated protein kinase (MAPK) and in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Regulation PLAT JUN 18982462 2006612 We further examined whether located in the tPA promoter is *involved* in FSH regulated [tPA] production , and demonstrated that FSH significantly stimulated AP-1 expression , whereas inclusion of H89 , UO126 , or SB20358 in the culture significantly decreased FSH induced AP-1 expression . Regulation PLAT KMS 1932113 169998 Stable expression of human [tissue-type plasminogen activator] *regulated* by beta-actin promoter in three human cell lines : HeLa , WI-38 VA13 and . Regulation PLAT LEP 20051227 2200938 In conclusion , our study shows that upregulates the expression of PAI-1 in vascular endothelial cells via activation of ERK1/2 but does not *regulate* [tPA] expression . Regulation PLAT LGALS1 22162045 2549126 Furthermore , we demonstrated that AnnexinA2 and receptors are *involved* in [tPA] signaling and inflammatory response in glial cells . Regulation PLAT LPA 10845888 700675 The relationship between [tissue plasminogen activator (tPA)] levels and the potential *regulation* by hypertriglyceridemic very low density ( HTG-VLDL ) was examined in a human umbilical vein endothelial cell ( HUVEC ) culture model system . Regulation PLAT LPA 11681624 873888 The results showed that O2*-/HO* free radical oxidized LDL and led to a dramatic decrease of PAI-1 release but did not *affect* [tPA] release , whereas copper oxidation of lipoproteins resulted in an increase in PAI-1 release and a decrease in tPA release . Regulation PLAT LPA 16235525 1470517 To investigate the *effect* of high density lipoprotein and oxidized high density on the synthesis of NO , the activity of NOS , and the secretion of [tPA] and PAI-1 by cultured human umbilical vein endothelial cells ( HUVEC ) . Regulation PLAT LPA 8123649 251183 We studied the *effect* of [ Lp(a) ] , low-density lipoprotein (LDL) , and high-density lipoprotein ( HDL ) on [tissue plasminogen activator (TPA)] secretion from human endothelial cells . Regulation PLAT LPA 8187237 256713 *Effects* of on the binding of plasminogen to fibrin and its activation by fibrin bound [tissue-type plasminogen activator] . Regulation PLAT MAPK1 12387826 1000204 Treatment of neurons with tPA and plasminogen induced a Ras dependent MAPK activation and [tPA-plasmin] degradation of NCAM was mediated in a *dependent* manner . Regulation PLAT MAPK1 12387826 1000232 Soluble NCAM transiently inhibited [tPA] mRNA expression levels in a *dependent* manner , while stimulation of MAPK alone induced tPA reduction in cells . Regulation PLAT MAPK1 16879221 1593913 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Regulation PLAT MAPK1 18982462 2006557 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Regulation PLAT MAPK1 18982462 2006599 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Regulation PLAT MAPK10 12387826 1000205 Treatment of neurons with tPA and plasminogen induced a Ras dependent MAPK activation and [tPA-plasmin] degradation of NCAM was mediated in a *dependent* manner . Regulation PLAT MAPK10 12387826 1000233 Soluble NCAM transiently inhibited [tPA] mRNA expression levels in a *dependent* manner , while stimulation of MAPK alone induced tPA reduction in cells . Regulation PLAT MAPK10 16879221 1593914 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Regulation PLAT MAPK10 18982462 2006558 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Regulation PLAT MAPK10 18982462 2006600 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Regulation PLAT MAPK11 12387826 1000206 Treatment of neurons with tPA and plasminogen induced a Ras dependent MAPK activation and [tPA-plasmin] degradation of NCAM was mediated in a *dependent* manner . Regulation PLAT MAPK11 12387826 1000234 Soluble NCAM transiently inhibited [tPA] mRNA expression levels in a *dependent* manner , while stimulation of MAPK alone induced tPA reduction in cells . Regulation PLAT MAPK11 16879221 1593915 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Regulation PLAT MAPK11 18982462 2006559 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Regulation PLAT MAPK11 18982462 2006601 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Regulation PLAT MAPK12 12387826 1000207 Treatment of neurons with tPA and plasminogen induced a Ras dependent MAPK activation and [tPA-plasmin] degradation of NCAM was mediated in a *dependent* manner . Regulation PLAT MAPK12 12387826 1000235 Soluble NCAM transiently inhibited [tPA] mRNA expression levels in a *dependent* manner , while stimulation of MAPK alone induced tPA reduction in cells . Regulation PLAT MAPK12 16879221 1593916 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Regulation PLAT MAPK12 18982462 2006560 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Regulation PLAT MAPK12 18982462 2006602 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Regulation PLAT MAPK13 12387826 1000208 Treatment of neurons with tPA and plasminogen induced a Ras dependent MAPK activation and [tPA-plasmin] degradation of NCAM was mediated in a *dependent* manner . Regulation PLAT MAPK13 12387826 1000236 Soluble NCAM transiently inhibited [tPA] mRNA expression levels in a *dependent* manner , while stimulation of MAPK alone induced tPA reduction in cells . Regulation PLAT MAPK13 16879221 1593917 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Regulation PLAT MAPK13 18982462 2006561 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Regulation PLAT MAPK13 18982462 2006603 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Regulation PLAT MAPK14 12387826 1000209 Treatment of neurons with tPA and plasminogen induced a Ras dependent MAPK activation and [tPA-plasmin] degradation of NCAM was mediated in a *dependent* manner . Regulation PLAT MAPK14 12387826 1000237 Soluble NCAM transiently inhibited [tPA] mRNA expression levels in a *dependent* manner , while stimulation of MAPK alone induced tPA reduction in cells . Regulation PLAT MAPK14 16879221 1593918 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Regulation PLAT MAPK14 18982462 2006562 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Regulation PLAT MAPK14 18982462 2006604 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Regulation PLAT MAPK15 12387826 1000203 Treatment of neurons with tPA and plasminogen induced a Ras dependent MAPK activation and [tPA-plasmin] degradation of NCAM was mediated in a *dependent* manner . Regulation PLAT MAPK15 12387826 1000231 Soluble NCAM transiently inhibited [tPA] mRNA expression levels in a *dependent* manner , while stimulation of MAPK alone induced tPA reduction in cells . Regulation PLAT MAPK15 16879221 1593912 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Regulation PLAT MAPK15 18982462 2006556 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Regulation PLAT MAPK15 18982462 2006597 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Regulation PLAT MAPK3 12387826 1000210 Treatment of neurons with tPA and plasminogen induced a Ras dependent MAPK activation and [tPA-plasmin] degradation of NCAM was mediated in a *dependent* manner . Regulation PLAT MAPK3 12387826 1000238 Soluble NCAM transiently inhibited [tPA] mRNA expression levels in a *dependent* manner , while stimulation of MAPK alone induced tPA reduction in cells . Regulation PLAT MAPK3 16879221 1593919 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Regulation PLAT MAPK3 18982462 2006563 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Regulation PLAT MAPK3 18982462 2006605 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Regulation PLAT MAPK4 12387826 1000211 Treatment of neurons with tPA and plasminogen induced a Ras dependent MAPK activation and [tPA-plasmin] degradation of NCAM was mediated in a *dependent* manner . Regulation PLAT MAPK4 12387826 1000239 Soluble NCAM transiently inhibited [tPA] mRNA expression levels in a *dependent* manner , while stimulation of MAPK alone induced tPA reduction in cells . Regulation PLAT MAPK4 16879221 1593920 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Regulation PLAT MAPK4 18982462 2006564 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Regulation PLAT MAPK4 18982462 2006606 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Regulation PLAT MAPK6 12387826 1000212 Treatment of neurons with tPA and plasminogen induced a Ras dependent MAPK activation and [tPA-plasmin] degradation of NCAM was mediated in a *dependent* manner . Regulation PLAT MAPK6 12387826 1000240 Soluble NCAM transiently inhibited [tPA] mRNA expression levels in a *dependent* manner , while stimulation of MAPK alone induced tPA reduction in cells . Regulation PLAT MAPK6 16879221 1593921 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Regulation PLAT MAPK6 18982462 2006565 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Regulation PLAT MAPK6 18982462 2006607 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Regulation PLAT MAPK7 12387826 1000213 Treatment of neurons with tPA and plasminogen induced a Ras dependent MAPK activation and [tPA-plasmin] degradation of NCAM was mediated in a *dependent* manner . Regulation PLAT MAPK7 12387826 1000241 Soluble NCAM transiently inhibited [tPA] mRNA expression levels in a *dependent* manner , while stimulation of MAPK alone induced tPA reduction in cells . Regulation PLAT MAPK7 16879221 1593922 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Regulation PLAT MAPK7 18982462 2006566 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Regulation PLAT MAPK7 18982462 2006608 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Regulation PLAT MAPK8 12387826 1000214 Treatment of neurons with tPA and plasminogen induced a Ras dependent MAPK activation and [tPA-plasmin] degradation of NCAM was mediated in a *dependent* manner . Regulation PLAT MAPK8 12387826 1000242 Soluble NCAM transiently inhibited [tPA] mRNA expression levels in a *dependent* manner , while stimulation of MAPK alone induced tPA reduction in cells . Regulation PLAT MAPK8 16879221 1593923 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Regulation PLAT MAPK8 18982462 2006567 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Regulation PLAT MAPK8 18982462 2006609 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Regulation PLAT MAPK9 12387826 1000215 Treatment of neurons with tPA and plasminogen induced a Ras dependent MAPK activation and [tPA-plasmin] degradation of NCAM was mediated in a *dependent* manner . Regulation PLAT MAPK9 12387826 1000243 Soluble NCAM transiently inhibited [tPA] mRNA expression levels in a *dependent* manner , while stimulation of MAPK alone induced tPA reduction in cells . Regulation PLAT MAPK9 16879221 1593924 TNF-alpha mediated suppression of [tissue type plasminogen activator] expression in vascular endothelial cells is NF-kappaB- and p38 *dependent* . Regulation PLAT MAPK9 18982462 2006568 *regulates* FSH induced expression of [tissue-type plasminogen activator] through an activator protein 1 response element . Regulation PLAT MAPK9 18982462 2006610 We have analyzed a possible *role* of and activator protein-1 (AP-1) in the regulation of FSH induced [tissue type plasminogen activator] ( tPA ) production in granulosa cells (GCs) prepared from DES treated immature rats ; Regulation PLAT MMP1 21615740 2464418 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Regulation PLAT MMP10 21615740 2464419 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Regulation PLAT MMP11 21615740 2464420 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Regulation PLAT MMP12 21615740 2464421 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Regulation PLAT MMP13 21615740 2464422 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Regulation PLAT MMP14 21615740 2464423 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Regulation PLAT MMP15 21615740 2464424 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Regulation PLAT MMP16 21615740 2464425 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Regulation PLAT MMP17 21615740 2464426 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Regulation PLAT MMP19 21615740 2464427 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Regulation PLAT MMP2 21615740 2464428 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Regulation PLAT MMP20 21615740 2464429 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Regulation PLAT MMP21 21615740 2464416 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Regulation PLAT MMP24 21615740 2464430 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Regulation PLAT MMP25 21615740 2464413 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Regulation PLAT MMP26 21615740 2464414 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Regulation PLAT MMP27 21615740 2464415 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Regulation PLAT MMP28 21615740 2464417 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Regulation PLAT MMP3 21615740 2464431 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Regulation PLAT MMP7 21615740 2464432 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Regulation PLAT MMP8 21615740 2464433 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Regulation PLAT MMP9 21615740 2464434 Thus , an extracellular zinc dependent , and BDNF mediated synaptic mechanism may *regulate* the levels and activity of [tPA] . Regulation PLAT NA 21621684 2436378 The *effect* of on [tPA] and PAI-1 production was tested in vitro in human mesothelial cells . Regulation PLAT OSM 9863709 556132 Since oncostatin M dramatically induces fibrinogen biosynthesis by hepatocytes and could be implicated in vascular injury leading to atherosclerosis , we have analyzed the *effect* of on PAI-1 , vWf and [tPA] secretion by endothelial cells . Regulation PLAT PLA2G1B 1811338 177298 *Participation* of in induction of [tissue plasminogen activator (t-PA)] production by human fibroblast , IMR-90 cells , stimulated by proteose peptone . Regulation PLAT PLAU 21786025 2476563 Based on above results , Ang II may induced cerebral aneurysm , ischemia/infarction on brain through RAS system by down regulating the mRNA levels of MMP 2 , , PAI , PPAR-A , MCSF1 and up *regulating* [tPA] and MCP-1 and ß carotene attenuates the disease condition and bring down to normal expression levels of above genes . Regulation PLAT PLG 12147618 970049 The serine proteases [tissue plasminogen activator (t-PA)] and urokinase plasminogen activator (u-PA) and their inhibitor , , *regulate* a variety of processes involved in tissue morphogenesis and differentiation . Regulation PLAT PLG 1388168 196360 It is possible that *regulates* the biosynthesis of [tPA] in HUVEC through the signal transduction pathway involving protein kinase . Regulation PLAT PLG 2298740 127633 We have reported that glucocorticoids and cyclic nucleotides *regulate* [tissue-type plasminogen activator] activity in HTC rat hepatoma cells primarily by modulating activator inhibitor ( PAI-1 ) gene expression . Regulation PLAT PLG 7818846 285376 To confirm that tPA and plasminogen are interacting with the same protein , we investigated the *effect* of excess cold on [tPA] binding and excess cold tPA on plasminogen binding in reversibility experiments . Regulation PLAT PRL 11324510 479818 This study was designed to investigate whether *affects* coordinated regulation of [tissue plasminogen activator (tPA)] and plasminogen activator inhibitor type-I ( PAI-I ) gene expression in rat granulosa cells in vitro . Regulation PLAT PRL 11324510 479820 Several methods , such as SDS-PAGE , immunoblot etc. were used to detect the *effect* of on [tPA] and PAI-I gene expression . Regulation PLAT PRL 9687315 522177 *regulation* of [tissue type plasminogen activator] and plasminogen activator inhibitor type-I gene expression in eCG primed rat granulosa cells in culture . Regulation PLAT PRL 9687315 522180 The present study was designed to investigate the *effect* of on plasminogen activator inhibitor-I ( PAI-I ) and [tissue type plasminogen activator] ( tPA ) gene expression in eCG primed granulosa cells in vitro . Regulation PLAT PTH 8119183 250604 The [tPA] *response* to was present in first passage osteoblast cultures at confluence and after 1 to 2 weeks of glucocorticoid treatment . Regulation PLAT RAB3D 15257287 1274344 and annexin A2 *play* a role in regulated secretion of vWF , but not [tPA] , from endothelial cells . Regulation PLAT RARA 7556191 327647 *Involvement* of in the stimulation of [tissue-type plasminogen-activator] gene expression in human endothelial cells . Regulation PLAT RARA 8695801 372857 We previously showed the *involvement* of in the induction of [tissue-type plasminogen activator (t-PA)] synthesis by RA in human umbilical vein endothelial cells ( HUVECs ) . Regulation PLAT RHO 17245169 1690809 The *effect* of a protein inhibitor , exoenzyme C3 transferase , on [tPA] production was also determined . Regulation PLAT RLN1 9875163 557164 *Regulation* of urokinase- and [tissue-type plasminogen activator] by in the uterus and cervix of the prepubertal gilt . Regulation PLAT RLN2 9875163 557165 *Regulation* of urokinase- and [tissue-type plasminogen activator] by in the uterus and cervix of the prepubertal gilt . Regulation PLAT RLN3 9875163 557166 *Regulation* of urokinase- and [tissue-type plasminogen activator] by in the uterus and cervix of the prepubertal gilt . Regulation PLAT SERPINB5 21810423 2505349 It further indicates that the *effect* of on uPA and [tPA] levels is cell type dependent . Regulation PLAT SERPINE1 10328761 612956 To demonstrate the utility of this assay as a screen for thrombolytic agents , a 14-amino-acid PAI-1-inhibitory peptide relieved the *effect* on [tPA] in a dose dependent fashion . Regulation PLAT SERPINE1 11110693 757343 This study found that genetic deficiency for , the primary physiologic *regulator* of [tissue-type plasminogen activator] ( tPA ) , prolonged the time to occlusive thrombosis following photochemical injury to carotid atherosclerotic plaque in apolipoprotein E-deficient ( apoE ( -/- ) ) mice . Regulation PLAT SERPINE1 17215448 1709674 inactivated soluble tPA at equimolar ratios in vitro , but it had no *effect* on the amidolytic or fibrinolytic activity of [RBC/tPA] . Regulation PLAT SERPINE1 18493852 1965430 Interestingly , the level of mRNA encoding plasminogen activator inhibitor-1 ( PAI-1 ) was increased by LPS stimulation and decreased back to control level after co-treatment with db-cAMP , suggesting that expression *plays* a major role in the regulation of [tPA] activity . Regulation PLAT SERPINE1 21465481 2523699 Under normal physiologic conditions , *controls* the activities of [uPA/tPA/plasmin/MMP] proteolytic activities and thus maintains the tissue homeostasis . Regulation PLAT SERPINE1 21790972 2579289 The increases in tPA , uPA , and a2-antiplasmin may counteract each other so that plasmin activity is not significantly altered in AD , but increased [tPA] may also *affect* synaptic plasticity , excitotoxic neuronal death and apoptosis . Regulation PLAT SERPINE1 2298740 127632 We have reported that glucocorticoids and cyclic nucleotides *regulate* [tissue-type plasminogen activator] activity in HTC rat hepatoma cells primarily by modulating plasminogen activator inhibitor ( ) gene expression . Regulation PLAT SERPINE1 23378038 2754805 The activity of [tPA] is *regulated* by an endogenous inhibitor ( PAI-1 ) , which is expressed mainly in astrocytes . Regulation PLAT SERPINE1 7792744 313462 One subject had clearly higher pre-exercise activity and smaller [tPA] *response* to exercise as compared to other subjects . Regulation PLAT SERPINE1 9798983 543696 These data suggest that the associations of [tPA] with acute thrombosis are *independent* of levels of but the mechanisms whereby enhanced fibrinolysis may predispose to thrombosis remain unclear . Regulation PLAT SNCA 20026244 2200279 *Regulation* of matrix metalloproteinase-9 and [tissue plasminogen activator] activity by in rat primary glial cells . Regulation PLAT SP1 10452548 637624 *Involvement* of in basal and retinoic acid induced transcription of the human [tissue-type plasminogen activator] gene . Regulation PLAT STX2 24578379 2929542 Our functional studies implicate a novel *role* for STXBP5 and in regulating [tPA] release . Regulation PLAT STXBP5 24578379 2929541 Our functional studies implicate a novel *role* for and STX2 in regulating [tPA] release . Regulation PLAT TAT 20432198 2282428 Percent body fat was negatively correlated to the [tPA] *response* to exercise ( r=-0.44 ) , and positively related to PAI-1 at baseline ( r=0.47 ) and post-exercise ( r=0.47 ) , and to post-exercise ( r=0.44 ) . Regulation PLAT TGFB1 9208283 440940 Opposing *effects* of interleukin-1 and on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT TGFB2 9208283 440941 Opposing *effects* of interleukin-1 and on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT TGFB3 9208283 440942 Opposing *effects* of interleukin-1 and on the regulation of [tissue-type plasminogen activator] and plasminogen activator inhibitor type-1 expression by human mesangial cells . Regulation PLAT TNF 11814314 892833 We have examined expression of the components of the plasminogen activation system in human astrocytoma U373-MG cells and found that interleukin 1beta (IL-1beta) , tumour necrosis factor alpha ) , interferon gamma (INF-gamma) and epidermal growth factor (EGF) specifically *regulate* the expression of [tissue-type plasminogen activator (t-PA)] , urokinase-type plasminogen activator ( u-PA ) , plasminogen activator inhibitor type 1 ( PAI-1 ) and protease nexin-1 (PN-1) . Regulation PLAT TNF 1328751 197934 In this study , we report the *effects* of recombinant human on the synthesis of [tissue-type plasminogen activator (t-PA)] and its inhibitor ( PAI-1 ) by human mesangial cells in culture . Regulation PLAT TNF 16879221 1593926 This study aims at investigating how *regulates* endothelial gene expression of the key fibrinolytic enzyme [tissue-type plasminogen activator (t-PA)] . Regulation PLAT TNF 17974273 1820570 In addition , T3A cells released more tissue factor ( TF ) , [tissue-type plasminogen activator (t-PA)] , plasminogen activator inhibitor ( PAI-1 ) and urine plasminogen activator ( u-PA ) than LSEC in *response* to . Regulation PLAT UGCG 21412817 2421295 such as hydrocortisone *regulate* the expression of [tPA/PAI-1] in various biological systems in a tissue-specific manner . Regulation PLAU ANXA5 16638992 1552956 The *effect* of on the release of [urokinase-type plasminogen activator] ( uPA ) from cultured RCE cells was determined by zymography , fluorogenic assay of PA activity , and enzyme linked immunosorbent assay . Regulation PLAU APOB 12167592 973163 We investigated the *effects* of on PA inhibitor-1 (PAI-1) , [urokinase-type PA (uPA)] , and tissue-type PA (tPA) in relationship to protein kinase C ( PKC ) in cultured human mesangial cells ( HMC ) . Regulation PLAU APOB 12167592 973167 The stimulatory *effects* of on PAI-1 , tPA , and [uPA] gene regulation in HMC were blocked by the inhibition of PKC using GF-109203X 12 h after treatment with LDL or downregulation of PKC using phorbol myristate acetate . Regulation PLAU APOB 12167592 973173 In summary , *regulates* PAI-1 , [uPA] , and tPA in biphasic patterns in HMC , and the upregulation of PAI-1 , uPA , and tPA after long-term LDL exposure seems to be mediated by a delayed PKC activation associated with an increased PA inhibitory activity . Regulation PLAU ASGR1 12152683 971411 In order to study the *role* of the in the rapid plasma clearance of [urokinase-type plasminogen activator] ( u-PA ) , a microtiter plate binding assay was developed using ASGPr purified from rat liver extracts . Regulation PLAU ASGR2 12152683 971412 In order to study the *role* of the in the rapid plasma clearance of [urokinase-type plasminogen activator] ( u-PA ) , a microtiter plate binding assay was developed using ASGPr purified from rat liver extracts . Regulation PLAU BRAF 22702340 2681739 To investigate the *effects* of ( V600E ) on the expression of [uPA] and uPAR and to evaluate the prognostic relevance of BRAF ( V600E ) alone or in combination with uPA and uPAR . Regulation PLAU BRMS1L 19165610 2038432 Further , we confirm that BRMS1 expression does not alter IKKbeta kinase activity suggesting that dependent [uPA] *regulation* does not occur through inhibition of the classical upstream activators of NF-kappaB . Regulation PLAU BSG 22443116 2588404 In this study , the *role* of in regulating [uPA] and invasion was investigated in oral squamous cell carcinoma ( OSCC ) progression . Regulation PLAU BSG 22443116 2588405 The paracrine *regulation* of [uPA] by was investigated by treating culture cells with EMMPRIN enriched membrane vesicles . Regulation PLAU CALCA 3021458 64543 In contrast to LLC-PK1 cells , the mutant did not exhibit production of [urokinase-type plasminogen activator] ( uPA ) in *response* to the hormones and vasopressin , but produced the expected levels of uPA upon stimulation by the receptor independent adenylate cyclase activators forskolin and cholera toxin , as well as by the phosphodiesterase inhibitor isobutylmethylxanthine and the 8-bromo analogue of adenosine cyclic monophosphate , Br8cAMP . Regulation PLAU CALCA 3653259 78376 T47D cells , however , failed to produce [uPA] in *response* to , forskolin , or the cAMP analog 8-bromo-cAMP , whereas LLC-PK1 cells produced high levels of uPA in response to all these agents . Regulation PLAU CAV1 15769846 1384305 In this study , we established a stable HCT 116 cell line with a gene encoding antisense caveolin-1 ( AS-cav-1 ) to examine the *effects* of , the main structural protein of caveolae , on the expression and localization of cathepsin B and [pro-uPA] , and their cell-surface receptors p11 and uPA receptor (uPAR) , respectively . Regulation PLAU CAV1 15769846 1384314 Based on these results , we hypothesize that *affects* the expression and localization of cathepsin B and [pro-uPA] , and their receptors , thereby mediating cell-surface proteolytic events associated with invasion of colon cancer cells . Regulation PLAU CDH1 10457348 639290 *Regulation* of [urokinase plasminogen activator (uPA)] activity by and hormones in mammary epithelial cells . Regulation PLAU CDH1 10457348 639296 These results indicate that [uPA] is an enzyme that may be important in the degradation of extracellular matrix during development and that specific interactions and hormones can *regulate* its activity . Regulation PLAU CDH1 1324844 195049 *Regulation* of [urokinase plasminogen activator] localization in keratinocytes by calcium ion and . Regulation PLAU CSF1 10727433 677895 *Regulation* of [urokinase plasminogen activator] gene transcription in the RAW264 murine macrophage cell line by macrophage colony stimulating factor ( ) is dependent upon the level of cell-surface receptor . Regulation PLAU CSF2 10727433 677896 *Regulation* of [urokinase plasminogen activator] gene transcription in the RAW264 murine macrophage cell line by macrophage ( CSF-1 ) is dependent upon the level of cell-surface receptor . Regulation PLAU CSF2 7684044 216603 When examined at similar concentrations , bFGF had little effect , and interleukin-1 alpha , tumor necrosis factor-alpha , and monocyte had no *effect* on macrophage [uPA] expression . Regulation PLAU CSF2 7760840 308024 *Regulation* of [urokinase-type plasminogen activator] gene transcription by macrophage . Regulation PLAU CSF3 16331631 1526318 3 ) primary and metastatic tumors significantly upregulated uPA and PAI-1 expression in Bik-/- mice relative to Bik+/+ mice at least through phosphorylation of ERK1/2 and 4 ) exogenous bikunin suppressed phosphorylation of ERK1/2 and upregulation of [uPA] and PAI-1 expression in 3LL cells in *response* to . Regulation PLAU CTNNBL1 11237830 790413 The *effect* of on the production of tissue factor ( TF ) , plasminogen activator inhibitor-2 ( PAI-2 ) , and [urokinase-type plasminogen activator] ( u-PA ) by human blood mononuclear cells ( MNC ) was evaluated by using functional and immunological assays and mRNA analysis . Regulation PLAU CXCL12 15201990 1260885 Recombinant stimulated in vitro invasiveness and scattering in CXCR4 expressing oral SCC cells , but the treatment did not *affect* the expression of matrix metalloproteinases or [urokinase-type plasminogen activator] . Regulation PLAU CXCL12 21567400 2562268 receptor 4 and ß1 integrin interaction *regulates* [urokinase-type plasminogen activator] expression in human colorectal cancer cells . Regulation PLAU CXCL12 21567400 2562277 The *effect* of on DLD-1 signaling and [uPA] expression was mediated by the CXCR4/ß1 integrin axis . Regulation PLAU CXCR4 21494253 2458315 AMD3100 directly induced SDF-1 release from CXCR4 ( + ) human bone marrow osteoblasts and endothelial cells and activated [uPA] in a *dependent* manner . Regulation PLAU DNMT1 21167264 2390794 *Effects* of and MEK inhibitors on the expression of RECK , MMP-9 , -2 , [uPA] and VEGF in response to arsenite stimulation in human uroepithelial cells . Regulation PLAU ECM1 11331280 827455 Because integrin signaling alters gene expression patterns , we investigated whether the expression levels of [uPA] , uPAR , and PAI-1 are *affected* by interactions . Regulation PLAU ECM2 11331280 827456 Because integrin signaling alters gene expression patterns , we investigated whether the expression levels of [uPA] , uPAR , and PAI-1 are *affected* by interactions . Regulation PLAU EDN1 1324671 195036 Using an immortalized human glomerular epithelial cell line ( E71 A1 ) , we studied the *effect* of , a potent vasoconstrictor peptide , on the synthesis of [urokinase type plasminogen activator] ( u-PA ) and its receptor ( u-PAR ) . Regulation PLAU EGF 11814314 892838 We have examined expression of the components of the plasminogen activation system in human astrocytoma U373-MG cells and found that interleukin 1beta (IL-1beta) , tumour necrosis factor alpha TNF-alpha ) , interferon gamma (INF-gamma) and specifically *regulate* the expression of tissue-type plasminogen activator (t-PA) , [urokinase-type plasminogen activator] ( u-PA ) , plasminogen activator inhibitor type 1 ( PAI-1 ) and protease nexin-1 (PN-1) . Regulation PLAU EGF 1657798 168946 There was no apparent *effect* of on the expression of [urokinase-type plasminogen activator] and 72-kDa type-IV collagenase in IMC-2 cells . Regulation PLAU EGF 20467333 2268921 Here , we characterized the signal transduction pathway ( s ) by which *regulates* [uPA] expression and promotes astrocytoma invasion . Regulation PLAU EGF 21303946 2403665 *dependent* induction of matrix metalloproteinase (MMP)-2 , pro- and active form of [urokinase plasminogen activator] , and chorionic gonadotropin ( CG ) -ß was noticed in shRNAmir-control cells , whereas these genes were suppressed in EGF treated shRNAmir-AP-2a cells . Regulation PLAU EGF 9639404 514076 Most notably , transfections with the Ets-1 and Ets-2 expression vectors potentiated [uPA] and MMP-9 promoter activation in *response* to . Regulation PLAU ELAVL1 14517288 1147353 These results indicate a *role* for and MK2 in regulating the expression of [uPA] and uPAR genes at the posttranscriptional level . Regulation PLAU EPHB2 11774742 890616 We next asked whether the mechanism of inhibition of uPA expression by bik is due to interference with MAP kinase , since PMA could also activate a signaling pathway involving *dependent* [uPA] expression . Regulation PLAU EPHB2 12458339 1021604 but not phospholipase D is *involved* in keratinocyte growth factor stimulated secretion of matrix metalloprotease-9 and [urokinase-type plasminogen activator] in SNU-16 human stomach cancer cell . Regulation PLAU EPHB2 16520550 1531197 *Regulation* of hepatocyte growth factor mediated [urokinase plasminogen activator] secretion by activation in human stomach cancer cell lines . Regulation PLAU ERBB2 11489825 845429 and ( c ) define the *effect* of overexpression on [uPA] and PAI-1 expression in breast cancer cells . Regulation PLAU ERBB2 11489825 845431 Furthermore , a full-length human HER-2/neu cDNA was introduced into five human breast cancer cell lines to define the *effects* of overexpression on [uPA] and PAI-1 expression . Regulation PLAU ETS1 10218628 608488 positively *regulates* expression of [urokinase-type plasminogen activator] ( uPA ) and invasiveness of astrocytic tumors . Regulation PLAU ETS1 10218628 608489 These results suggest that *plays* an essential role in regulation of [uPA] gene expression , which in turn contributes to the invasive growth of astrocytic tumors . Regulation PLAU FGF1 1905574 161606 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Regulation PLAU FGF1 8868466 389248 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Regulation PLAU FGF10 1905574 161607 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Regulation PLAU FGF10 8868466 389249 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Regulation PLAU FGF11 1905574 161608 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Regulation PLAU FGF11 8868466 389250 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Regulation PLAU FGF12 1905574 161609 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Regulation PLAU FGF12 8868466 389251 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Regulation PLAU FGF13 1905574 161610 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Regulation PLAU FGF13 8868466 389252 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Regulation PLAU FGF14 1905574 161611 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Regulation PLAU FGF14 8868466 389253 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Regulation PLAU FGF16 1905574 161612 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Regulation PLAU FGF16 8868466 389254 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Regulation PLAU FGF17 1905574 161613 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Regulation PLAU FGF17 8868466 389255 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Regulation PLAU FGF18 1905574 161614 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Regulation PLAU FGF18 8868466 389256 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Regulation PLAU FGF19 1905574 161615 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Regulation PLAU FGF19 8868466 389257 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Regulation PLAU FGF2 12370824 996110 Here we examined the signal transduction pathways involved in the *regulation* of [uPA] production by . Regulation PLAU FGF2 12413883 1010991 The positive *effect* of on [uPA] enzymatic activity was slightly potentiated in the presence of fibronectin . Regulation PLAU FGF2 1905574 161616 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Regulation PLAU FGF2 7684044 216601 In experiments reported here , we have examined the potential regulatory *effects* of and TGF-beta 1 on macrophage [uPA] expression . Regulation PLAU FGF2 7860647 295254 Transcriptional and posttranscriptional *regulation* of [urokinase-type plasminogen activator] expression in endothelial cells by . Regulation PLAU FGF2 7860647 295255 did not *affect* [uPA] mRNA stability , as evaluated by chase experiments with the mRNA synthesis inhibitor actinomycin D. Upregulation of uPA mRNA was followed by a delayed increase in uPA protein synthesis paralleled by an increase in secreted and cell associated uPA activity . Regulation PLAU FGF2 7860647 295258 These results provide evidence that can *affect* [uPA] expression in endothelial GM 7373 cells both at transcriptional and posttranscriptional translational levels . Regulation PLAU FGF2 8868466 389258 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Regulation PLAU FGF2 9442043 483065 Differential *regulation* of [urokinase-type plasminogen activator] expression by and serum in myogenesis . Regulation PLAU FGF2 9442043 483071 Altogether , these results indicate a dual *regulation* of the [uPA] gene by and serum , which ensures uPA expression throughout the whole myogenic process in different myoblastic lineages . Regulation PLAU FGF2 9442043 483072 The *effects* of and serum on [uPA] expression may contribute to the proteolytic activity required during myoblast migration and fusion , as well as in muscle regeneration . Regulation PLAU FGF20 1905574 161617 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Regulation PLAU FGF20 8868466 389259 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Regulation PLAU FGF21 1905574 161618 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Regulation PLAU FGF21 8868466 389260 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Regulation PLAU FGF22 1905574 161619 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Regulation PLAU FGF22 8868466 389261 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Regulation PLAU FGF23 1905574 161620 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Regulation PLAU FGF23 8868466 389262 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Regulation PLAU FGF3 1905574 161621 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Regulation PLAU FGF3 8868466 389263 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Regulation PLAU FGF4 1905574 161622 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Regulation PLAU FGF4 8868466 389264 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Regulation PLAU FGF5 1905574 161623 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Regulation PLAU FGF5 8868466 389265 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Regulation PLAU FGF6 1905574 161624 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Regulation PLAU FGF6 8868466 389266 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Regulation PLAU FGF7 1905574 161625 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Regulation PLAU FGF7 8868466 389267 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Regulation PLAU FGF8 1905574 161626 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Regulation PLAU FGF8 8868466 389268 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Regulation PLAU FGF9 1905574 161627 The expression and localization of [urokinase-type plasminogen activator] and its type 1 inhibitor are *regulated* by retinoic acid and in human teratocarcinoma cells . Regulation PLAU FGF9 8868466 389269 In the present paper we investigated the *role* of the interaction of FGF-2 with tyrosine-kinase ( TK ) in mediating [uPA] up-regulation in these cells . Regulation PLAU FOS 8300623 248675 DNA-protein interaction studies , together with mRNA and protein analyses , indicate that c-Jun , but not , is *involved* in OA-dependent [uPA] gene induction . Regulation PLAU GDF15 19540205 2136563 and subsequent [urokinase-type plasminogen activator] mediate cell death *responses* by ribotoxic anisomycin in HCT-116 colon cancer cells . Regulation PLAU GDNF 12182908 977911 These findings suggested that the inhibitory *effects* of on [sc-uPA] activation by Lys-plasmin and Glu- or Lys-plasminogen activation by tc-uPA were related to the binding of ATF ( by its C-terminal Lys ( 135 ) and internal Lys/Arg residue ) with the kringle 1-4 of plasmin and plasminogen , respectively . Regulation PLAU GEMIN4 12750156 1119621 These results indicate that membrane bound and soluble p97 affect the migration capacity of endothelial and melanoma cells and suggest that could be *involved* in the regulation of plasminogen activation by interacting with [pro-uPA] and plasminogen . Regulation PLAU GIF 11814314 892839 We have examined expression of the components of the plasminogen activation system in human astrocytoma U373-MG cells and found that interleukin 1beta (IL-1beta) , tumour necrosis factor alpha TNF-alpha ) , and epidermal growth factor (EGF) specifically *regulate* the expression of tissue-type plasminogen activator (t-PA) , [urokinase-type plasminogen activator] ( u-PA ) , plasminogen activator inhibitor type 1 ( PAI-1 ) and protease nexin-1 (PN-1) . Regulation PLAU GNRH1 12466358 1022353 Cetrorelix , a peptide GnRH antagonist specific for the GnRH I receptor , was capable of inhibiting the regulatory *effects* of , but not GnRH II on [uPA] and PAI-1 expression levels in primary cell cultures . Regulation PLAU GNRH1 12915673 1129971 Cetrorelix , a GnRH receptor antagonist , inhibited the regulatory *effects* of , but not GnRH II , on [uPA] and PAI-1 expression levels in these decidual stromal cell cultures . Regulation PLAU GNRH1 20400076 2345303 The *effect* of and -II on the production of select cytokines ( hCG , interleukin [ IL] 8 , IL-6 , matrix metalloproteinase 3 , monocyte chemoattractant protein 1 , vascular endothelial growth factor , soluble Fms-like tyrosine kinase 1 , [urokinase-type plasminogen activator] , and plasminogen activator inhibitor 1 ) were measured by ELISA and normalized for protein content . Regulation PLAU GNRH2 12466358 1022354 Cetrorelix , a peptide GnRH antagonist specific for the GnRH I receptor , was capable of inhibiting the regulatory *effects* of GnRH I , but not on [uPA] and PAI-1 expression levels in primary cell cultures . Regulation PLAU GNRH2 12915673 1129972 Cetrorelix , a GnRH receptor antagonist , inhibited the regulatory *effects* of GnRH I , but not , on [uPA] and PAI-1 expression levels in these decidual stromal cell cultures . Regulation PLAU GNRH2 20400076 2345304 The *effect* of on the production of select cytokines ( hCG , interleukin [ IL] 8 , IL-6 , matrix metalloproteinase 3 , monocyte chemoattractant protein 1 , vascular endothelial growth factor , soluble Fms-like tyrosine kinase 1 , [urokinase-type plasminogen activator] , and plasminogen activator inhibitor 1 ) were measured by ELISA and normalized for protein content . Regulation PLAU GPI 9630624 512393 This study examines the *effects* of on [urokinase-type plasminogen activator] ( uPA ) production and wound healing by human fibroblasts . Regulation PLAU GRAP2 14598883 1161243 To investigate the role of HGF/c-met signaling on metastasis in cancer cells stimulated with HGF , we examined the *effects* of a specific MEK1 inhibitor ( PD98059 ) and a MAP kinase inhibitor ( SB203580 ) on HGF induced [uPA] expression in pancreatic cancer cell lines , L3.6PL and IMIM-PC2 . Regulation PLAU GRAP2 16520550 1531206 In order to investigate roles of HGF/c-Met signaling in tumor progression and metastasis in stomach cancers , we determined *effects* of a specific MEK1 inhibitor ( PD098059 ) and a kinase inhibitor ( SB203580 ) on HGF mediated cell proliferation and [uPA] expression in stomach cancer cell lines ( NUGC-3 and MKN-28 ) . Regulation PLAU GRB2 9038378 415569 Regulation of the [urokinase-type plasminogen activator] gene by the oncogene Tpr-Met *involves* . Regulation PLAU HGF 12755996 1090563 *Effects* of on [urokinase-type plasminogen activator] ( uPA ) and uPA receptor in DU145 prostate cancer cells . Regulation PLAU HGF 12755996 1090564 We therefore examined *effects* of on [uPA] and uPAR expression in DU145 cells . Regulation PLAU HGF 12755996 1090566 *Effects* of on [uPA] expression in culture medium were determined by Western blotting and fibrin zymography , effects on uPAR expression in cell associated protein were examined by Western blotting . Regulation PLAU HGF 15782129 1410038 Thus , we show that certain GA drugs ( fM-GAi ) in an *dependent* manner block [uPA-plasmin] activation in tumor cells at femtomolar levels . Regulation PLAU HGF 17992475 1860061 *Role* of signaling in regulating [urokinase plasminogen activator] on invasiveness in human hepatocellular carcinoma : a potential therapeutic target . Regulation PLAU HGF 19497102 2098077 regulates Rac-1 induced ROS production through the Akt pathway and ROS *regulates* [uPA] production and invasion via MAP kinase , which provides novel insight into the mechanisms underlying the progression of gastric cancer . Regulation PLAU HNF1B 7665606 322019 *Role* of in cell-specific cAMP induction of the [urokinase-type plasminogen activator] gene . Regulation PLAU HPR 10762018 683352 The preliminary results of other studies on the *effects* of <4-HPR> on tissue plasminogen activator (t-PA) , plasminogen activator inhibitor-1 ( PAI-1 ) , and [urokinase plasminogen activator (uk-PA)] and on the relevance of circulating p53 antibodies with relapse will be also presented . Regulation PLAU HPR 10824459 696246 The purpose of this study was to evaluate the *effects* of <4-HPR> on [uPA] and plasminogen activator inhibitor-1 ( PAI-1 ) in prostate cancer . Regulation PLAU HRAS 14984765 1214731 In this review we describe the mechanisms that underlie *regulation* of vascular endothelial growth factor ( VEGF ) , cyclooxygenases ( COX-1/-2 ) , thrombospondins ( TSP-1/-2 ) , [urokinase plasminogen activator (uPA)] and matrix metalloproteases-2 and -9 ( MMP-2/-9 ) . Regulation PLAU HRAS 20123981 2219859 Thus , the differential *regulation* of [uPA] and uPAR by c-Myc and correlates with the effects of these two oncoproteins on cell motility , invasiveness , and survival . Regulation PLAU IFIT1 14699120 1211604 To our knowledge , this is the first report that ( lck ) in presence of H/R *regulates* MEK-1 dependent ERK1/2 phosphorylation and [uPA] secretion through tyrosine phosphorylation of EGF receptor , and it further demonstrates that all of these signaling molecules ultimately control the motility of breast cancer cells . Regulation PLAU IFNA1 12070711 955894 The *regulation* of [urokinase plasminogen activator] receptor ( uPAR ) gene expression by ( IFN-alpha , or Intron A ) and interferon-gamma (IFN-gamma) was studied in a HCT116 colon cancer cell line . Regulation PLAU IFNA10 12070711 955895 The *regulation* of [urokinase plasminogen activator] receptor ( uPAR ) gene expression by ( IFN-alpha , or Intron A ) and interferon-gamma (IFN-gamma) was studied in a HCT116 colon cancer cell line . Regulation PLAU IFNA13 12070711 955896 The *regulation* of [urokinase plasminogen activator] receptor ( uPAR ) gene expression by ( IFN-alpha , or Intron A ) and interferon-gamma (IFN-gamma) was studied in a HCT116 colon cancer cell line . Regulation PLAU IFNA14 12070711 955897 The *regulation* of [urokinase plasminogen activator] receptor ( uPAR ) gene expression by ( IFN-alpha , or Intron A ) and interferon-gamma (IFN-gamma) was studied in a HCT116 colon cancer cell line . Regulation PLAU IFNA16 12070711 955898 The *regulation* of [urokinase plasminogen activator] receptor ( uPAR ) gene expression by ( IFN-alpha , or Intron A ) and interferon-gamma (IFN-gamma) was studied in a HCT116 colon cancer cell line . Regulation PLAU IFNA17 12070711 955899 The *regulation* of [urokinase plasminogen activator] receptor ( uPAR ) gene expression by ( IFN-alpha , or Intron A ) and interferon-gamma (IFN-gamma) was studied in a HCT116 colon cancer cell line . Regulation PLAU IFNA2 12070711 955900 The *regulation* of [urokinase plasminogen activator] receptor ( uPAR ) gene expression by ( IFN-alpha , or Intron A ) and interferon-gamma (IFN-gamma) was studied in a HCT116 colon cancer cell line . Regulation PLAU IFNA2 8061114 268531 We investigated the *effect* of ( IFN-alpha 2 ) on interleukin-1 alpha (IL-1 alpha) induced up-regulation of [urokinase type plasminogen activator] ( u-PA ) expression in human foreskin microvascular endothelial cells ( HFMEC ) and human umbilical vein endothelial cells ( HUVEC ) in vitro . Regulation PLAU IFNA21 12070711 955901 The *regulation* of [urokinase plasminogen activator] receptor ( uPAR ) gene expression by ( IFN-alpha , or Intron A ) and interferon-gamma (IFN-gamma) was studied in a HCT116 colon cancer cell line . Regulation PLAU IFNA4 12070711 955902 The *regulation* of [urokinase plasminogen activator] receptor ( uPAR ) gene expression by ( IFN-alpha , or Intron A ) and interferon-gamma (IFN-gamma) was studied in a HCT116 colon cancer cell line . Regulation PLAU IFNA5 12070711 955903 The *regulation* of [urokinase plasminogen activator] receptor ( uPAR ) gene expression by ( IFN-alpha , or Intron A ) and interferon-gamma (IFN-gamma) was studied in a HCT116 colon cancer cell line . Regulation PLAU IFNA6 12070711 955904 The *regulation* of [urokinase plasminogen activator] receptor ( uPAR ) gene expression by ( IFN-alpha , or Intron A ) and interferon-gamma (IFN-gamma) was studied in a HCT116 colon cancer cell line . Regulation PLAU IFNA7 12070711 955905 The *regulation* of [urokinase plasminogen activator] receptor ( uPAR ) gene expression by ( IFN-alpha , or Intron A ) and interferon-gamma (IFN-gamma) was studied in a HCT116 colon cancer cell line . Regulation PLAU IFNA8 12070711 955906 The *regulation* of [urokinase plasminogen activator] receptor ( uPAR ) gene expression by ( IFN-alpha , or Intron A ) and interferon-gamma (IFN-gamma) was studied in a HCT116 colon cancer cell line . Regulation PLAU IFNG 12070711 955907 The *regulation* of [urokinase plasminogen activator] receptor ( uPAR ) gene expression by interferon-alpha ( IFN-alpha , or Intron A ) and was studied in a HCT116 colon cancer cell line . Regulation PLAU IGF1 10509812 650986 These data suggest that in human breast fibroblasts *controls* the expression of [uPA] and that , possibly due to an altered sensitivity to uPA , tumor associated fibroblasts have escaped this local control mechanism . Regulation PLAU IGF1 10524682 653857 Abnormal *regulation* of [urokinase plasminogen activator] by in human osteoarthritic subchondral osteoblasts . Regulation PLAU IL10 18819934 1970410 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL10 23183001 2730210 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL11 18819934 1970411 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL11 23183001 2730211 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL13 18819934 1970412 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL13 23183001 2730212 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL15 18819934 1970413 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL15 23183001 2730213 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL16 18819934 1970414 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL16 23183001 2730214 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL18 18819934 1970415 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL18 23183001 2730215 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL19 18819934 1970416 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL19 23183001 2730216 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL1A 10454570 638025 We have investigated the in vivo and in vitro *regulation* of the human [urokinase-type plasminogen activator] ( uPA ) gene by and analyzed the transcription factors and signalling pathways involved in the response of the -2.0-kb uPA enhancer to IL-1 induction and to tetradecanoyl phorbol acetate ( TPA ) induction . Regulation PLAU IL1A 12390531 1000537 Here , we show that oncostatin M (OSM) and *regulate* the expression of plasminogen activator inhibitor-1 ( PAI-1 ) and [urokinase-type plasminogen activator] ( uPA ) in human astrocytes . Regulation PLAU IL1A 12930304 1132333 Our results confirm the role of uPA in acantholysis and suggest an *involvement* of in [uPA] induction . Regulation PLAU IL1A 14714609 1181706 To clarify the role of human gastric fibroblasts in acute inflammatory conditions such as gastric ulcer , the *effects* of and tumor necrosis factor (TNF)-alpha on the expression of [uPA] and uPAR , which were suggested to be associated with tissue remodeling , in gastric fibroblasts were investigated . Regulation PLAU IL1A 16313928 1526166 In this study , we examined the *effect* of on the expression of the MMPs , TIMPs , tPA , [uPA] , and PAI-1 genes in osteoblasts derived from the rat osteosarcoma cell line ROS 17/2.8 . Regulation PLAU IL1B 11238529 790737 *regulates* [urokinase plasminogen activator (u-PA)] , u-PA receptor , soluble u-PA receptor , and plasminogen activator inhibitor-1 messenger ribonucleic acid expression in cultured human endometrial stromal cells . Regulation PLAU IL1B 11814314 892840 We have examined expression of the components of the plasminogen activation system in human astrocytoma U373-MG cells and found that , tumour necrosis factor alpha TNF-alpha ) , interferon gamma (INF-gamma) and epidermal growth factor (EGF) specifically *regulate* the expression of tissue-type plasminogen activator (t-PA) , [urokinase-type plasminogen activator] ( u-PA ) , plasminogen activator inhibitor type 1 ( PAI-1 ) and protease nexin-1 (PN-1) . Regulation PLAU IL2 11890690 920422 Herein , we investigate the *effects* of on NK cell [uPA] and uPAR . Regulation PLAU IL2 18819934 1970417 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL2 23183001 2730217 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL20 18819934 1970418 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL20 23183001 2730218 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL21 18819934 1970419 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL21 23183001 2730219 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL22 18819934 1970402 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL22 23183001 2730202 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL24 18819934 1970400 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL24 23183001 2730200 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL25 18819934 1970401 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL25 23183001 2730201 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL26 18819934 1970406 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL26 23183001 2730206 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL27 18819934 1970407 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL27 23183001 2730207 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL3 18819934 1970420 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL3 23183001 2730220 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL31 18819934 1970408 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL31 23183001 2730208 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL32 18819934 1970405 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL32 23183001 2730205 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL33 18819934 1970404 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL33 23183001 2730204 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL34 18819934 1970409 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL34 23183001 2730209 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL37 18819934 1970403 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL37 23183001 2730203 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL4 18819934 1970421 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL4 23183001 2730221 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL4 7586221 333740 In order to determine whether the T-cell lymphokines interleukin-4 (IL-4) and gamma interferon ( gamma-IFN ) affect SMC fibrinolysis and migration , we examined the *effects* of human recombinant and gamma-IFN on human aortic SMC tissue-type plasminogen activator (TPA) , [urokinase-type plasminogen activator] ( UPA ) , and plasminogen activator inhibitor type-1 ( PAI-1 ) antigen production , as determined by enzyme linked immunosorbent assays . Regulation PLAU IL5 18819934 1970422 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL5 23183001 2730222 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL6 18819934 1970423 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL6 23183001 2730223 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL7 18819934 1970424 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL7 23183001 2730224 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL8 10889925 710491 In contrast , neither antibody nor anti-hepatocyte growth factor ( HGF beta ) antibody *affected* [uPA] activity in the endothelial cells . Regulation PLAU IL8 12175988 976889 In addition , the [uPA] inhibitor , PAI-1 , was not *affected* by . Regulation PLAU IL8 12175988 976890 The mRNA expression of [uPA] in the keratinocytes was found to be constitutively elevated and was not *affected* by . Regulation PLAU IL8 15491751 1321409 did not *affect* cellular migration , MMP2 activation , or [uPA] expression . Regulation PLAU IL8 18819934 1970425 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL8 23183001 2730225 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU IL9 18819934 1970426 Sphingosine-1-phosphate and independently *regulate* plasminogen activator inhibitor-1 and [urokinase-type plasminogen activator] receptor expression in glioblastoma cells : implications for invasiveness . Regulation PLAU IL9 23183001 2730226 Therefore , the *effect* of on the production of [urokinase type plasminogen activator] by C2C12 myoblasts was determined in the present study . Regulation PLAU ILF3 22986534 2833263 Nuclear localization of ILF3 highlights the *role* of in sustained [uPA] expression as a transcription activator and pri-miRNA processing blocker . Regulation PLAU INS 12008951 940755 In breast stroma [urokinase plasminogen activator (uPA)] is predominantly expressed by fibroblasts located in the near vicinity of tumor cells , and fibroblast derived may be *involved* in inhibiting the expression of uPA in these fibroblasts . Regulation PLAU INTS2 14688127 1190432 To determine the role of [uPA] immune *responses* , wild-type ( WT ) and uPA ( -/- ) mice were primed and challenged with schistosomal egg antigen (SEA) . Regulation PLAU ITGA3 10791952 714402 [Urinary-type plasminogen activator (uPA)] expression and uPA receptor localization are *regulated* by in oral keratinocytes . Regulation PLAU ITGB1 10791952 714403 [Urinary-type plasminogen activator (uPA)] expression and uPA receptor localization are *regulated* by in oral keratinocytes . Regulation PLAU JUN 10942386 721319 Taken together , our results show that the JNK signaling pathway links external MNNG stimulation and *dependent* [uPA] gene expression , providing the first functional dissection of a transcription coupled signal transduction pathway for MNNG . Regulation PLAU JUN 11774742 890617 We next asked whether the mechanism of inhibition of uPA expression by bik is due to interference with MAP kinase , since PMA could also activate a signaling pathway involving *dependent* [uPA] expression . Regulation PLAU JUN 20467333 2268937 In summary , these results suggest that c-Src , mitogen activated protein kinase , and a composite on the uPA promoter are *responsible* for EGF induced [uPA] expression and GBM invasion . Regulation PLAU JUN 8300623 248676 DNA-protein interaction studies , together with mRNA and protein analyses , indicate that , but not c-Fos , is *involved* in OA-dependent [uPA] gene induction . Regulation PLAU KHSRP 16912916 1614857 These results indicate that expression of [uPA] , MMP-2 , MMP-9 , and TIMP-1 are directly *regulated* by expression of ( NTR ) and its downstream signal transduction cascade . Regulation PLAU KLF6 10666204 665400 Furthermore , concomitant expression of Zf9 and uPA proteins was observed in arterial endothelial cells after balloon injury in rats , suggesting a potential *role* of in [uPA] expression not only in vitro but also in vivo . Regulation PLAU KRAS 14984765 1214732 In this review we describe the mechanisms that underlie *regulation* of vascular endothelial growth factor ( VEGF ) , cyclooxygenases ( COX-1/-2 ) , thrombospondins ( TSP-1/-2 ) , [urokinase plasminogen activator (uPA)] and matrix metalloproteases-2 and -9 ( MMP-2/-9 ) . Regulation PLAU KRAS 20123981 2219860 Thus , the differential *regulation* of [uPA] and uPAR by c-Myc and correlates with the effects of these two oncoproteins on cell motility , invasiveness , and survival . Regulation PLAU LCK 14534291 1174964 Tyrosine kinase *regulates* cell motility and nuclear factor kappaB mediated secretion of [urokinase type plasminogen activator] through tyrosine phosphorylation of IkappaBalpha following hypoxia/reoxygenation . Regulation PLAU LCK 14534291 1174990 To our knowledge , this is the first report that in presence of H/R *regulates* NFkappaB activation , [uPA] secretion , and cell motility through tyrosine phosphorylation of IkappaBalpha and further demonstrates an important redox regulated pathway for NFkappaB activation following H/R injury that is independent of IkappaB kinase/IkappaBalpha mediated signaling pathways . Regulation PLAU LPA 10589790 572235 In contrast , expression of the edg-4 LPA receptor was markedly increased in ovarian cancer cell lines as compared with NOE cell lines , raising the possibility that the edg-4 LPA receptor contributes to the ability of ovarian cancer cells but not NOE cells to produce [uPA] in *response* to . Regulation PLAU LPAR2 18461672 1909845 To explore the *role* of in regulating lysophosphatidic acid (LPA) induced [urokinase plasminogen activator (uPA)] activation , cell invasion , and migration in human ovarian cancer cell line SKOV-3 . Regulation PLAU MAP2K1 11774742 890618 We next asked whether the mechanism of inhibition of uPA expression by bik is due to interference with MAP kinase , since PMA could also activate a signaling pathway involving *dependent* [uPA] expression . Regulation PLAU MAP2K1 14598883 1161244 To investigate the role of HGF/c-met signaling on metastasis in cancer cells stimulated with HGF , we examined the *effects* of a specific inhibitor ( PD98059 ) and a p38 MAP kinase inhibitor ( SB203580 ) on HGF induced [uPA] expression in pancreatic cancer cell lines , L3.6PL and IMIM-PC2 . Regulation PLAU MAP2K1 15743030 1352204 In this study , we first examined the *effect* of mitogen activated protein kinase kinase ( ) inhibitors on the production of matrix metalloproteinases ( MMPs ) , [urokinase-type plasminogen activator] ( uPA ) , and tissue inhibitors of metalloproteinases ( TIMPs ) in a human gallbladder cancer cell line , NOZ cells in vitro . Regulation PLAU MAP2K1 16520550 1531198 *Regulation* of hepatocyte growth factor mediated [urokinase plasminogen activator] secretion by activation in human stomach cancer cell lines . Regulation PLAU MAP2K1 16520550 1531207 In order to investigate roles of HGF/c-Met signaling in tumor progression and metastasis in stomach cancers , we determined *effects* of a specific inhibitor ( PD098059 ) and a p38 kinase inhibitor ( SB203580 ) on HGF mediated cell proliferation and [uPA] expression in stomach cancer cell lines ( NUGC-3 and MKN-28 ) . Regulation PLAU MAP2K1 21167264 2390795 *Effects* of DNMT and inhibitors on the expression of RECK , MMP-9 , -2 , [uPA] and VEGF in response to arsenite stimulation in human uroepithelial cells . Regulation PLAU MAP2K2 11774742 890619 We next asked whether the mechanism of inhibition of uPA expression by bik is due to interference with MAP kinase , since PMA could also activate a signaling pathway involving *dependent* [uPA] expression . Regulation PLAU MAP2K2 15743030 1352205 In this study , we first examined the *effect* of ( MEK ) inhibitors on the production of matrix metalloproteinases ( MMPs ) , [urokinase-type plasminogen activator] ( uPA ) , and tissue inhibitors of metalloproteinases ( TIMPs ) in a human gallbladder cancer cell line , NOZ cells in vitro . Regulation PLAU MAP2K2 16520550 1531199 *Regulation* of hepatocyte growth factor mediated [urokinase plasminogen activator] secretion by activation in human stomach cancer cell lines . Regulation PLAU MAP2K2 21167264 2390796 *Effects* of DNMT and inhibitors on the expression of RECK , MMP-9 , -2 , [uPA] and VEGF in response to arsenite stimulation in human uroepithelial cells . Regulation PLAU MAP2K3 11774742 890620 We next asked whether the mechanism of inhibition of uPA expression by bik is due to interference with MAP kinase , since PMA could also activate a signaling pathway involving *dependent* [uPA] expression . Regulation PLAU MAP2K3 15743030 1352206 In this study , we first examined the *effect* of mitogen activated protein kinase kinase ( ) inhibitors on the production of matrix metalloproteinases ( MMPs ) , [urokinase-type plasminogen activator] ( uPA ) , and tissue inhibitors of metalloproteinases ( TIMPs ) in a human gallbladder cancer cell line , NOZ cells in vitro . Regulation PLAU MAP2K3 16520550 1531200 *Regulation* of hepatocyte growth factor mediated [urokinase plasminogen activator] secretion by activation in human stomach cancer cell lines . Regulation PLAU MAP2K3 21167264 2390797 *Effects* of DNMT and inhibitors on the expression of RECK , MMP-9 , -2 , [uPA] and VEGF in response to arsenite stimulation in human uroepithelial cells . Regulation PLAU MAP2K4 11774742 890621 We next asked whether the mechanism of inhibition of uPA expression by bik is due to interference with MAP kinase , since PMA could also activate a signaling pathway involving *dependent* [uPA] expression . Regulation PLAU MAP2K4 15743030 1352207 In this study , we first examined the *effect* of ( MEK ) inhibitors on the production of matrix metalloproteinases ( MMPs ) , [urokinase-type plasminogen activator] ( uPA ) , and tissue inhibitors of metalloproteinases ( TIMPs ) in a human gallbladder cancer cell line , NOZ cells in vitro . Regulation PLAU MAP2K4 16520550 1531201 *Regulation* of hepatocyte growth factor mediated [urokinase plasminogen activator] secretion by activation in human stomach cancer cell lines . Regulation PLAU MAP2K4 21167264 2390798 *Effects* of DNMT and inhibitors on the expression of RECK , MMP-9 , -2 , [uPA] and VEGF in response to arsenite stimulation in human uroepithelial cells . Regulation PLAU MAP2K5 11774742 890622 We next asked whether the mechanism of inhibition of uPA expression by bik is due to interference with MAP kinase , since PMA could also activate a signaling pathway involving *dependent* [uPA] expression . Regulation PLAU MAP2K5 15743030 1352208 In this study , we first examined the *effect* of mitogen activated protein kinase kinase ( ) inhibitors on the production of matrix metalloproteinases ( MMPs ) , [urokinase-type plasminogen activator] ( uPA ) , and tissue inhibitors of metalloproteinases ( TIMPs ) in a human gallbladder cancer cell line , NOZ cells in vitro . Regulation PLAU MAP2K5 16520550 1531202 *Regulation* of hepatocyte growth factor mediated [urokinase plasminogen activator] secretion by activation in human stomach cancer cell lines . Regulation PLAU MAP2K5 21167264 2390799 *Effects* of DNMT and inhibitors on the expression of RECK , MMP-9 , -2 , [uPA] and VEGF in response to arsenite stimulation in human uroepithelial cells . Regulation PLAU MAP2K6 11774742 890623 We next asked whether the mechanism of inhibition of uPA expression by bik is due to interference with MAP kinase , since PMA could also activate a signaling pathway involving *dependent* [uPA] expression . Regulation PLAU MAP2K6 15743030 1352209 In this study , we first examined the *effect* of mitogen activated protein kinase kinase ( ) inhibitors on the production of matrix metalloproteinases ( MMPs ) , [urokinase-type plasminogen activator] ( uPA ) , and tissue inhibitors of metalloproteinases ( TIMPs ) in a human gallbladder cancer cell line , NOZ cells in vitro . Regulation PLAU MAP2K6 16520550 1531203 *Regulation* of hepatocyte growth factor mediated [urokinase plasminogen activator] secretion by activation in human stomach cancer cell lines . Regulation PLAU MAP2K6 21167264 2390800 *Effects* of DNMT and inhibitors on the expression of RECK , MMP-9 , -2 , [uPA] and VEGF in response to arsenite stimulation in human uroepithelial cells . Regulation PLAU MAP2K7 11774742 890624 We next asked whether the mechanism of inhibition of uPA expression by bik is due to interference with MAP kinase , since PMA could also activate a signaling pathway involving *dependent* [uPA] expression . Regulation PLAU MAP2K7 15743030 1352210 In this study , we first examined the *effect* of mitogen activated protein kinase kinase ( ) inhibitors on the production of matrix metalloproteinases ( MMPs ) , [urokinase-type plasminogen activator] ( uPA ) , and tissue inhibitors of metalloproteinases ( TIMPs ) in a human gallbladder cancer cell line , NOZ cells in vitro . Regulation PLAU MAP2K7 16520550 1531204 *Regulation* of hepatocyte growth factor mediated [urokinase plasminogen activator] secretion by activation in human stomach cancer cell lines . Regulation PLAU MAP2K7 21167264 2390801 *Effects* of DNMT and inhibitors on the expression of RECK , MMP-9 , -2 , [uPA] and VEGF in response to arsenite stimulation in human uroepithelial cells . Regulation PLAU MAP3K1 12493778 1056693 Here we show inducible [uPA] expression is *controlled* by , a MAPK kinase kinase that regulates the ERK1/2 and JNK pathways . Regulation PLAU MAP3K2 12493778 1056699 Importantly , disrupted expression of , a related MAPK kinase kinase , had no *effect* on [uPA] activity . Regulation PLAU MAPK3 15557793 1340903 *Involvement* of and p38 MAP kinase in doxorubicin induced [uPA] expression in human RC-K8 lymphoma and NCI-H69 small cell lung carcinoma cells . Regulation PLAU MAPKAPK2 12377770 1020003 Among the potential downstream effectors of p38 MAPK , we found that only *affects* alphav integrin mediated [uPA] up-regulation significantly . Regulation PLAU MAPKAPK2 14517288 1147354 These results indicate a *role* for HuR and in regulating the expression of [uPA] and uPAR genes at the posttranscriptional level . Regulation PLAU MET 17992475 1860062 *Role* of hepatocyte growth signaling in regulating [urokinase plasminogen activator] on invasiveness in human hepatocellular carcinoma : a potential therapeutic target . Regulation PLAU MET 9038378 415570 *Regulation* of the [urokinase-type plasminogen activator] gene by the oncogene involves GRB2 . Regulation PLAU MET 9038378 415574 Mutation of Y1356 , which abrogates GRB2 binding , reduced the induction to half of the control level , while mutation of Y1349 showed little effect on uPA induction , suggesting an important but partly replaceable role for GRB2 in *dependent* [uPA] gene induction . Regulation PLAU MMP9 20736374 2313457 This study shows a novel molecular pathway in which *regulates* [uPA] activity and tumor cell invasion through cleavage of PN-1 . Regulation PLAU MUC1 18381451 1892910 Antitumor *effects* of involves the modulation of [urokinase-type plasminogen activator] and signal transducer and activator of transcription 1 expression in tumor cells . Regulation PLAU MYC 20123981 2219861 Thus , the differential *regulation* of [uPA] and uPAR by and Ras correlates with the effects of these two oncoproteins on cell motility , invasiveness , and survival . Regulation PLAU NFKB1 14532966 1152274 We have recently demonstrated that constitutively active is *responsible* for the increased secretion of [uPA] and that inhibition of NF-kappaB suppresses secretion of uPA and cell migration of highly invasive cancer cells . Regulation PLAU NFKB1 16109653 1445280 To evaluate the *role* of transcription factor in [uPA] and uPAR gene transcription with H. pylori stimulation , the effect of NF-kappaB inhibitor MG132 on H. pylori induced uPA and uPAR mRNA expression was examined . Regulation PLAU NFKB1 17571974 1763298 Expression of [uPA] is *regulated* in part by the oxidant-sensitive transcription factor , , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Regulation PLAU NFKB1 20204677 2272553 Our results shows that TGF-beta1 stimulation of [uPA] and MMP-9 expression *involve* NOXs dependent ROS and , activation , demonstrated by using DPI , NOXs inhibitor , ROS scavenger N-acetylcysteine and SN50 , an NFkb inhibitor . Regulation PLAU NFKB1 20502321 2301211 *dependent* regulation of [urokinase plasminogen activator] by proanthocyanidin-rich grape seed extract : effect on invasion by prostate cancer cells . Regulation PLAU NOS1 24325546 2883366 *Involvement* of in matrix metalloproteinase-9- and/or [urokinase plasminogen activator] receptor mediated glioma cell migration . Regulation PLAU NOS2 24325546 2883367 *Involvement* of in matrix metalloproteinase-9- and/or [urokinase plasminogen activator] receptor mediated glioma cell migration . Regulation PLAU NOS3 24325546 2883368 *Involvement* of in matrix metalloproteinase-9- and/or [urokinase plasminogen activator] receptor mediated glioma cell migration . Regulation PLAU NPR2 21395696 2438304 Plasminogen activator inhibitors (PAI)-1 , 2 and the [uPA] receptor were also *targets* for in vitro . Regulation PLAU NRAS 14984765 1214733 In this review we describe the mechanisms that underlie *regulation* of vascular endothelial growth factor ( VEGF ) , cyclooxygenases ( COX-1/-2 ) , thrombospondins ( TSP-1/-2 ) , [urokinase plasminogen activator (uPA)] and matrix metalloproteases-2 and -9 ( MMP-2/-9 ) . Regulation PLAU NRAS 20123981 2219862 Thus , the differential *regulation* of [uPA] and uPAR by c-Myc and correlates with the effects of these two oncoproteins on cell motility , invasiveness , and survival . Regulation PLAU PAICS 8977672 403444 Cell bound [uPA] is *regulated* by . Regulation PLAU PBK 15880258 1406201 Our results suggest that is *involved* in the regulation of [uPA] expression , which might provide a new clue to further understanding the regulation mechanism of uPA expression . Regulation PLAU PI3 12370824 996112 Stable expression of activated mutant p110alpha catalytic subunit of PI3-kinase into IBE cells decreased FGF-2 mediated uPA production , suggesting that exhibited the negative regulatory *effect* on [uPA] production . Regulation PLAU PI3 16012053 1431632 Taken together , OPN induces NFkappaB activity and uPA secretion by activating PI 3'-kinase/Akt/IKK mediated signaling pathways and further demonstrates a functional molecular link between OPN induced *dependent* Akt phosphorylation and NFkappaB mediated [uPA] secretion , and all of these ultimately control the motility and invasiveness of breast cancer cells . Regulation PLAU PLAUR 11016879 736529 The generation of the broad specificity serine protease plasmin in the pericellular environment is *regulated* by binding of the [urokinase-type plasminogen activator] ( uPA ) to its specific glycosylphosphatidylinositol (GPI) anchored cell-surface receptor , . Regulation PLAU PLAUR 12004248 939984 Novel posttranscriptional pathways *regulate* expression of [uPA] , , and plasminogen activator inhibitor-1 . Regulation PLAU PLAUR 12704669 1082386 We then suggest that [uPA] *regulates* uPAR expression in NSCLC at a posttranscriptional level by increasing through a cellular factor that binds the coding region of uPAR-mRNA . Regulation PLAU PLAUR 19123477 2037347 Plasmin(ogen) is activated on cell surfaces by [urokinase-type PA (uPA)] , and is *regulated* by and plasminogen activator inhibitor-1 ( PAI-1 ) . Regulation PLAU PLAUR 19377974 2065623 The results demonstrate that both and plasminogen *play* critical roles in [pro-uPA] activation both in vitro and in vivo . Regulation PLAU PLAUR 23238745 2736698 These findings demonstrate that , whose expression is regulated by uPA , can , in turn , *regulate* [uPA] expression through a mechanism involving its functional interaction with integrins and fMLF-Rs . Regulation PLAU PLAUR 9151959 430894 To distinguish between these possibilities the *effect* of a recombinant soluble ( residues 1-277 ) form of , uPAR- ( 1-277 ) -peptide , on reciprocal [pro-uPA/plasminogen] activation was studied . Regulation PLAU PLD1 12458339 1021605 Src/ERK but not is *involved* in keratinocyte growth factor stimulated secretion of matrix metalloprotease-9 and [urokinase-type plasminogen activator] in SNU-16 human stomach cancer cell . Regulation PLAU PLD1 9150275 430226 These results suggest for the first time that [uPA] production is *regulated* by and PKC signal transduction pathways in murine mammary adenocarcinoma cells . Regulation PLAU PLD2 12458339 1021606 Src/ERK but not is *involved* in keratinocyte growth factor stimulated secretion of matrix metalloprotease-9 and [urokinase-type plasminogen activator] in SNU-16 human stomach cancer cell . Regulation PLAU PLD2 9150275 430227 These results suggest for the first time that [uPA] production is *regulated* by and PKC signal transduction pathways in murine mammary adenocarcinoma cells . Regulation PLAU PLD3 12458339 1021600 Src/ERK but not is *involved* in keratinocyte growth factor stimulated secretion of matrix metalloprotease-9 and [urokinase-type plasminogen activator] in SNU-16 human stomach cancer cell . Regulation PLAU PLD3 9150275 430222 These results suggest for the first time that [uPA] production is *regulated* by and PKC signal transduction pathways in murine mammary adenocarcinoma cells . Regulation PLAU PLD4 12458339 1021601 Src/ERK but not is *involved* in keratinocyte growth factor stimulated secretion of matrix metalloprotease-9 and [urokinase-type plasminogen activator] in SNU-16 human stomach cancer cell . Regulation PLAU PLD4 9150275 430223 These results suggest for the first time that [uPA] production is *regulated* by and PKC signal transduction pathways in murine mammary adenocarcinoma cells . Regulation PLAU PLD5 12458339 1021602 Src/ERK but not is *involved* in keratinocyte growth factor stimulated secretion of matrix metalloprotease-9 and [urokinase-type plasminogen activator] in SNU-16 human stomach cancer cell . Regulation PLAU PLD5 9150275 430224 These results suggest for the first time that [uPA] production is *regulated* by and PKC signal transduction pathways in murine mammary adenocarcinoma cells . Regulation PLAU PLD6 12458339 1021603 Src/ERK but not is *involved* in keratinocyte growth factor stimulated secretion of matrix metalloprotease-9 and [urokinase-type plasminogen activator] in SNU-16 human stomach cancer cell . Regulation PLAU PLD6 9150275 430225 These results suggest for the first time that [uPA] production is *regulated* by and PKC signal transduction pathways in murine mammary adenocarcinoma cells . Regulation PLAU PLG 12147618 970050 The serine proteases tissue plasminogen activator (t-PA) and [urokinase plasminogen activator (u-PA)] and their inhibitor , , *regulate* a variety of processes involved in tissue morphogenesis and differentiation . Regulation PLAU PLG 19377974 2065624 The results demonstrate that both uPAR and *play* critical roles in [pro-uPA] activation both in vitro and in vivo . Regulation PLAU PLG 1966892 149815 We have studied the *effect* of activator inhibitors PAI-1 and PAI-2 on the binding of [urokinase-type plasminogen activator] ( u-PA ) to its receptor in the human choriocarcinoma cell line JAR . Regulation PLAU PLG 7556451 327683 [uPA] is *regulated* by the activator inhibitors PAI-1 and PAI-2 . Regulation PLAU PPARG 14515149 1147031 We aimed to investigate the *effect* of ligands on expression of MMP-1 and [urokinase plasminogen activator (uPA)] in human microvascular endothelial cells ( HMEC-1 ) . Regulation PLAU PTGS2 21592330 2441487 *dependent* and independent activation of [CK2a-Akt/uPA] signal is mainly involved in urothelial carcinoma cell survival , moreover , not only COX2 but also CK2a could be direct targets of COX2 inhibitors . Regulation PLAU PTH 1322417 192138 In order to determine the mechanism by which parathyroid hormone (PTH) stimulates plasminogen activator (PA) activity in rat osteoblasts , we investigated the *effect* of human ( 1-34 ) [ hPTH ( 1-34 ) ] on the synthesis of mRNAs for tissue-type PA (tPA) , [urokinase-type PA (uPA)] , and PA inhibitor-1 (PAI-1) , and on release of PA activity and PAI-1 protein in both normal rat calvarial osteoblasts and UMR 106-01 osteogenic sarcoma cells . Regulation PLAU RAF1 15653692 1381604 In this report , we demonstrate that LPA activates NF-kappaB in a *dependent* manner and that blocking NF-kappaB activation with either non-phosphorylable IkappaB or dominant negative IkappaB kinase abolished LPA induced [uPA] up-regulation and uPA promoter activation . Regulation PLAU RALA 10467419 640831 We have therefore investigated whether *plays* a role in [uPA] and MMP overproduction that is observed in response to oncogenic signals . Regulation PLAU RELA 10467400 640767 Overexpression of [urokinase-type plasminogen activator] in pancreatic adenocarcinoma is *regulated* by constitutively activated . Regulation PLAU RELA 14532966 1152275 We have recently demonstrated that constitutively active is *responsible* for the increased secretion of [uPA] and that inhibition of NF-kappaB suppresses secretion of uPA and cell migration of highly invasive cancer cells . Regulation PLAU RELA 16109653 1445281 To evaluate the *role* of transcription factor in [uPA] and uPAR gene transcription with H. pylori stimulation , the effect of NF-kappaB inhibitor MG132 on H. pylori induced uPA and uPAR mRNA expression was examined . Regulation PLAU RELA 17571974 1763299 Expression of [uPA] is *regulated* in part by the oxidant-sensitive transcription factor , , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Regulation PLAU RELA 20204677 2272554 Our results shows that TGF-beta1 stimulation of [uPA] and MMP-9 expression *involve* NOXs dependent ROS and , activation , demonstrated by using DPI , NOXs inhibitor , ROS scavenger N-acetylcysteine and SN50 , an NFkb inhibitor . Regulation PLAU RELA 20502321 2301212 dependent *regulation* of [urokinase plasminogen activator] by proanthocyanidin-rich grape seed extract : effect on invasion by prostate cancer cells . Regulation PLAU SEMA5A 23661031 2819249 The *effect* of on the expression of [uPA] was evaluated by ELISA and Western blotting as well as RT-PCR assays , respectively . Regulation PLAU SERPINB2 10506599 649343 A dissemination risk index determined on primary tumor and taking into account the different *effects* of PAI-1 and on [uPA] can be of major help in clinical management of breast cancer , particularly in node negative patients . Regulation PLAU SERPINB2 11348470 814405 [Urokinase-type plasminogen activator] activity is specifically *controlled* by . Regulation PLAU SERPINB2 18162327 1883068 The endogenous inhibitors of this system , PAI-1 and , *regulate* [uPA-uPAR] activity by either direct inhibition or affecting cell surface expression and internalization . Regulation PLAU SERPINB5 10987285 732444 The goal of this study was to investigate the *effect* of on cell surface associated [uPA] . Regulation PLAU SERPINB5 11751384 889884 The inhibitory *effect* of on pericellular [uPA] correlates with significantly decreased cell invasion potential and motility in vitro . Regulation PLAU SERPINB5 15846059 1439532 *regulates* hypoxia mediated stimulation of [uPA/uPAR] complex in invasive breast cancer cells . Regulation PLAU SERPINB5 15846059 1439535 In this study , we investigated the *effect* of on the regulation of hypoxia induced expression of [urokinase-type plasminogen activator] ( uPA ) and its receptor ( uPAR ) , with respect to invasive potential in metastatic breast cells MDA-MB-231 . Regulation PLAU SERPINB5 16123583 1482301 Hypoxia effects : implications for *regulation* of the [uPA/uPAR] complex . Regulation PLAU SERPINB5 16618739 1551076 The *effects* on surface associated [uPA] and uPAR required the interaction between uPA and uPAR . Regulation PLAU SERPINB5 21810423 2505350 It further indicates that the *effect* of on [uPA] and tPA levels is cell type dependent . Regulation PLAU SERPINE1 10506599 649342 A dissemination risk index determined on primary tumor and taking into account the different *effects* of and PAI-2 on [uPA] can be of major help in clinical management of breast cancer , particularly in node negative patients . Regulation PLAU SERPINE1 10817507 693725 This indicated that the inhibitory activity of was required for its anti-apoptotic effect but the [urokinase-type plasminogen activator] receptor was not *involved* . Regulation PLAU SERPINE1 11348470 814404 [Urokinase-type plasminogen activator] activity is specifically *controlled* by and -2 . Regulation PLAU SERPINE1 16077925 1442403 ( PAI-1 ) *regulates* the proteolytic activity of [urokinase-type plasminogen activator] ( uPA ) and there is increasing evidence for a PAI-1 role in regulating cell migration/invasion by other mechanisms like vitronectin (VN) binding and lipoprotein-receptor related protein ( LRP ) binding . Regulation PLAU SERPINE1 17258797 1783465 [uPA] activity is *controlled* by its principal inhibitor , the , but it can also be inhibited by PAI-3 . Regulation PLAU SERPINE1 18162327 1883067 The endogenous inhibitors of this system , and PAI-2 , *regulate* [uPA-uPAR] activity by either direct inhibition or affecting cell surface expression and internalization . Regulation PLAU SERPINE1 19123477 2037346 Plasmin(ogen) is activated on cell surfaces by [urokinase-type PA (uPA)] , and is *regulated* by uPAR and ( PAI-1 ) . Regulation PLAU SERPINE1 21465481 2523700 Under normal physiologic conditions , *controls* the activities of [uPA/tPA/plasmin/MMP] proteolytic activities and thus maintains the tissue homeostasis . Regulation PLAU SETD2 20807755 2324630 At 1 % O ( 2 ) , vascular endothelial growth factor was regulated by both and HIF-2a , but glucose transporter 1 , carbonic anhydrase 9 , and [urokinase-type plasminogen activator] receptor were *regulated* by HIF-1a rather than by HIF-2a . Regulation PLAU SFTPC 15854129 1399955 Subsequently , we examined whether *affected* the production of [urokinase-type plasminogen activator] ( uPA ) , an important regulator of angiogenesis , and found that SPC stimulated the expression of uPA at both the transcriptional and translational levels . Regulation PLAU SMAD3 21798735 2605056 In the present study , we analysed the *role* of TGF-ß1 induced activation in the [urokinase type plasminogen activator] ( uPA ) production , as well as in cell migration and E-cadherin downregulation in transformed PDV keratinocyte cell line . Regulation PLAU SMAD4 16959768 1639573 *dependent* regulation of [urokinase plasminogen activator] secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-beta . Regulation PLAU SPP1 14704150 1219038 However , the *role* ( s ) of on AP-1 mediated [uPA] secretion and cell motility and the involvement of c-Src/epidermal growth factor receptor (EGFR) in these processes in breast cancer cells are not well defined . Regulation PLAU SPRED2 19908229 2247806 In the present work , we analyzed the *role* of in the [urokinase-type plasminogen activator] ( uPA ) stimulation , EMT and cell migration by TGF-beta1 . Regulation PLAU SRC 12458339 1021599 but not phospholipase D is *involved* in keratinocyte growth factor stimulated secretion of matrix metalloprotease-9 and [urokinase-type plasminogen activator] in SNU-16 human stomach cancer cell . Regulation PLAU ST14 14747469 1226284 We now investigate whether *affects* activation of receptor bound [uPA] and contributes to the invasiveness of HRA human ovarian cancer cells in vitro and tumor behavior in nude mice . Regulation PLAU ST14 14747469 1226288 Our data identify a novel *role* for for activation of receptor bound [uPA] . Regulation PLAU SYK 16474166 1548364 Moreover , Syk and Lck play differential roles in regulating Sp1 activation and expressions of melanoma cell adhesion molecule (MelCAM) , [urokinase-type plasminogen activator] ( uPA ) , matrix metalloproteinase-9 (MMP-9) , and vascular endothelial growth factor ( VEGF ) in *response* to H/R. Overexpression of wild type inhibited the H/R induced uPA , MMP-9 , and VEGF expression but up-regulated MelCAM expression . Regulation PLAU TCF12 17571974 1763287 Expression of [uPA] is *regulated* in part by the oxidant-sensitive , NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Regulation PLAU TCF12 24084233 2882567 We recently reported that the FOSL1 of the AP-1 family *plays* a pivotal role in the regulation of the level of the avß3 and [uPA-uPAR] complexes on the surface of endothelial cells . Regulation PLAU TCF15 17571974 1763288 Expression of [uPA] is *regulated* in part by the oxidant-sensitive , NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Regulation PLAU TCF15 24084233 2882568 We recently reported that the FOSL1 of the AP-1 family *plays* a pivotal role in the regulation of the level of the avß3 and [uPA-uPAR] complexes on the surface of endothelial cells . Regulation PLAU TCF19 17571974 1763289 Expression of [uPA] is *regulated* in part by the oxidant-sensitive , NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Regulation PLAU TCF19 24084233 2882569 We recently reported that the FOSL1 of the AP-1 family *plays* a pivotal role in the regulation of the level of the avß3 and [uPA-uPAR] complexes on the surface of endothelial cells . Regulation PLAU TCF20 17571974 1763290 Expression of [uPA] is *regulated* in part by the oxidant-sensitive , NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Regulation PLAU TCF20 24084233 2882570 We recently reported that the FOSL1 of the AP-1 family *plays* a pivotal role in the regulation of the level of the avß3 and [uPA-uPAR] complexes on the surface of endothelial cells . Regulation PLAU TCF21 17571974 1763291 Expression of [uPA] is *regulated* in part by the oxidant-sensitive , NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Regulation PLAU TCF21 24084233 2882571 We recently reported that the FOSL1 of the AP-1 family *plays* a pivotal role in the regulation of the level of the avß3 and [uPA-uPAR] complexes on the surface of endothelial cells . Regulation PLAU TCF23 17571974 1763295 Expression of [uPA] is *regulated* in part by the oxidant-sensitive , NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Regulation PLAU TCF23 24084233 2882575 We recently reported that the FOSL1 of the AP-1 family *plays* a pivotal role in the regulation of the level of the avß3 and [uPA-uPAR] complexes on the surface of endothelial cells . Regulation PLAU TCF24 17571974 1763297 Expression of [uPA] is *regulated* in part by the oxidant-sensitive , NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Regulation PLAU TCF24 24084233 2882577 We recently reported that the FOSL1 of the AP-1 family *plays* a pivotal role in the regulation of the level of the avß3 and [uPA-uPAR] complexes on the surface of endothelial cells . Regulation PLAU TCF25 17571974 1763296 Expression of [uPA] is *regulated* in part by the oxidant-sensitive , NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Regulation PLAU TCF25 24084233 2882576 We recently reported that the FOSL1 of the AP-1 family *plays* a pivotal role in the regulation of the level of the avß3 and [uPA-uPAR] complexes on the surface of endothelial cells . Regulation PLAU TCF3 17571974 1763292 Expression of [uPA] is *regulated* in part by the oxidant-sensitive , NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Regulation PLAU TCF3 24084233 2882572 We recently reported that the FOSL1 of the AP-1 family *plays* a pivotal role in the regulation of the level of the avß3 and [uPA-uPAR] complexes on the surface of endothelial cells . Regulation PLAU TCF4 17571974 1763293 Expression of [uPA] is *regulated* in part by the oxidant-sensitive , NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Regulation PLAU TCF4 24084233 2882573 We recently reported that the FOSL1 of the AP-1 family *plays* a pivotal role in the regulation of the level of the avß3 and [uPA-uPAR] complexes on the surface of endothelial cells . Regulation PLAU TCF7 17571974 1763294 Expression of [uPA] is *regulated* in part by the oxidant-sensitive , NF-kappa B (NF-kappaB) , which is activated by intracellular reactive oxygen intermediates ( ROI ) . Regulation PLAU TCF7 24084233 2882574 We recently reported that the FOSL1 of the AP-1 family *plays* a pivotal role in the regulation of the level of the avß3 and [uPA-uPAR] complexes on the surface of endothelial cells . Regulation PLAU TGFA 9160733 431800 The aim of the present study was to examine the regulatory *role* of ( TGF alpha ) on [urokinase plasminogen activator (uPA)] gene expression and protein levels in hen granulosa cells from different stages of ovarian follicular development in vitro . Regulation PLAU TGFB1 10482694 643848 Neither TSP-1 nor had an *effect* on [uPA] production . Regulation PLAU TGFB1 12767061 1094283 The synergistic induction of uPA protein resulted of an early and transient augmentation of steady state mRNA level and was blocked in the presence of the MAP kinase kinase inhibitor PD098059 , strongly suggesting that synergistic *effect* of AR and on [uPA] expression required MAPK pathway . Regulation PLAU TGFB1 12841684 1108340 A divergent *effect* of on the [uPA] enzyme activity was observed ( 28 % decrease in PC3 and 131 % increase in DU145 cells ) . Regulation PLAU TGFB1 15201140 1288927 The p38 MAPK inhibitor SB203580 reversed the *dependent* inhibition of [uPA] activity but not its morphogenetic effect . Regulation PLAU TGFB1 15452360 1354476 These results show that the activity and gene expression of [uPA] are *regulated* by both acetaldehyde and and that the proteolytic activity in the extracellular space is reduced by the influence of TGF-beta1 . Regulation PLAU TGFB1 3276718 90594 *Regulation* of the synthesis and activity of [urokinase plasminogen activator] in A549 human lung carcinoma cells by . Regulation PLAU TGFB1 7622580 315896 In these studies , the *effect* of ( TGF-beta 1 ) on [uPA] , uPA receptor , and plasminogen receptor expression by human THP-1 macrophage was examined . Regulation PLAU TGFB1 7684044 216600 In experiments reported here , we have examined the potential regulatory *effects* of bFGF and on macrophage [uPA] expression . Regulation PLAU TGFB1 9695745 524385 In this study , we determined the *effect* of TSP-1 and on [uPA] and uPAR expression and on tumor cell invasion in pancreatic cancer . Regulation PLAU TGFB2 3276718 90595 *Regulation* of the synthesis and activity of [urokinase plasminogen activator] in A549 human lung carcinoma cells by . Regulation PLAU TGFB3 3276718 90596 *Regulation* of the synthesis and activity of [urokinase plasminogen activator] in A549 human lung carcinoma cells by . Regulation PLAU THBS1 10482694 643849 Neither nor TGF-beta1 had an *effect* on [uPA] production . Regulation PLAU THBS1 9695745 524386 In this study , we determined the *effect* of and TGF-beta 1 on [uPA] and uPAR expression and on tumor cell invasion in pancreatic cancer . Regulation PLAU TIMP1 10534069 562518 *controls* the synthesis of [uPA] in the PDL cells . Regulation PLAU TNF 11814314 892837 We have examined expression of the components of the plasminogen activation system in human astrocytoma U373-MG cells and found that interleukin 1beta (IL-1beta) , tumour necrosis factor alpha ) , interferon gamma (INF-gamma) and epidermal growth factor (EGF) specifically *regulate* the expression of tissue-type plasminogen activator (t-PA) , [urokinase-type plasminogen activator] ( u-PA ) , plasminogen activator inhibitor type 1 ( PAI-1 ) and protease nexin-1 (PN-1) . Regulation PLAU TNF 12930304 1132332 Our results confirm the role of uPA in acantholysis and suggest an *involvement* of in [uPA] induction . Regulation PLAU TNF 14714609 1181705 To clarify the role of human gastric fibroblasts in acute inflammatory conditions such as gastric ulcer , the *effects* of interleukin (IL)-1beta and on the expression of [uPA] and uPAR , which were suggested to be associated with tissue remodeling , in gastric fibroblasts were investigated . Regulation PLAU TNP1 9414430 408187 The *effect* of on cell proliferation and [urokinase-type plasminogen activator] and its inhibitor in human lung cancer cell lines . Regulation PLAU TNP1 9414430 408192 We therefore investigated the inhibitory effect of TNP-470 on cancer cell proliferation , and the suppressive *effect* of on [urokinase-type plasminogen activator] ( u-PA ) and its inhibitor ( PAI-1 ) , in human lung cancer cell lines in vitro . Regulation PLAU TNP2 9414430 408188 The *effect* of on cell proliferation and [urokinase-type plasminogen activator] and its inhibitor in human lung cancer cell lines . Regulation PLAU TNP2 9414430 408193 We therefore investigated the inhibitory effect of on cancer cell proliferation , and the suppressive *effect* of TNP-470 on [urokinase-type plasminogen activator] ( u-PA ) and its inhibitor ( PAI-1 ) , in human lung cancer cell lines in vitro . Regulation PLAU TP53 18836029 1993849 In addition , [uPA] mediated signaling *controls* the expression of the tumor suppressor protein in lung epithelial cells at the posttranslational level . Regulation PLAU TPR 9038378 415568 *Regulation* of the [urokinase-type plasminogen activator] gene by the oncogene involves GRB2 . Regulation PLAU VTN 1377687 190519 *regulates* the synthesis and localization of [urokinase-type plasminogen activator] in HT-1080 cells . Regulation PLAU VTN 17344041 1740995 Our results indicate that *dependent* localization of [uPA] to adhesion sites requires the sequential binding of vitronectin integrins and uPAR to vitronectin . Regulation PLAU WAS 18565284 1929508 Zymography assay was used to analyze the *effect* of on matrix metalloproteinase (MMP)-2 , MMP-9 , and [urokinase plasminogen activator (uPA)] secretion from HT1080 cells . Regulation PLAU ZEB1 23340304 2747434 Through multiple experimental approaches , colorectal carcinoma ( CRC ) cell lines and samples from human primary CRC and ZEB1 ( -/- ) mice were used to examine mediated *regulation* of [uPA] and PAI-1 at the protein , mRNA , and transcriptional level . Regulation PLAU ZEB1 23340304 2747438 *regulates* [uPA] and PAI-1 in opposite directions : induces uPA and inhibits PAI-1 . Regulation PLAUR EPHB2 17427199 1748799 *dependent* [uPAR] expression is required for motility via phosphorylation of P70S6K in human hepatocarcinoma cells . Regulation PLAUR EPHB2 22221673 2686254 We also showed that pathway activation was *involved* in the regulation of [uPAR] gene expression in SMCs . Regulation PLAUR IL1B 11238529 790742 We investigated the *role* of in regulating u-PA , PAI-1 , [u-PAR] , and soluble u-PAR messenger ribonucleic acid ( mRNA ) expression in cultured human endometrial stromal cells using quantitative competitive PCR . Regulation PLAUR IL1B 12545698 1028806 The *effect* of on [uPAR] expression was assessed . Regulation PLAUR MAP2K6 17427199 1748805 *dependent* [uPAR] expression is required for motility via phosphorylation of P70S6K in human hepatocarcinoma cells . Regulation PLAUR MAP2K6 22221673 2686260 We also showed that pathway activation was *involved* in the regulation of [uPAR] gene expression in SMCs . Regulation PLAUR PLAU 10190285 603364 Chemotaxis is induced through an *dependent* conformational change in [uPAR] which uncovers a very potent chemotactic epitope acting through a pertussis-toxin sensitive step and activating intracellular tyrosine kinases . Regulation PLAUR PLAU 10903758 713194 The requirement for [uPAR] in neutrophil recruitment is *independent* of the serine protease , as neutrophil recruitment in uPA-/- mice is indistinguishable from recruitment in WT mice . Regulation PLAUR PLAU 11598185 870507 Soluble [uPAR] bound to recombinant alpha3beta1 in a *dependent* manner ( K ( d ) < 20 nM ) and binding was blocked by a 17-mer alpha3beta1 integrin peptide ( alpha325 ) homologous to the CD11b uPAR binding site . Regulation PLAUR PLAU 11728456 884663 We then propose that *regulates* [uPAR] expression at a post-transcriptional level , by promoting the binding of uPAR mRNA to a stabilizing factor . Regulation PLAUR PLAU 12704669 1082387 We then suggest that *regulates* [uPAR] expression in NSCLC at a posttranscriptional level by increasing uPAR-stability through a cellular factor that binds the coding region of uPAR-mRNA . Regulation PLAUR PLAU 12754207 1113096 We studied whether binding of [uPAR] to alpha 5 beta 1 in cis is involved in adhesion and migration of Chinese hamster ovary cells in *response* to immobilized . Regulation PLAUR PLAU 16143315 1461262 Accordingly , both *dependent* enhancement of [uPAR] expression and cell migration were strongly reduced in transfected cells . Regulation PLAUR PLAU 17963689 1850028 We have studied the *role* of the ligand on [uPAR] localization and on the composition of the lipid membrane microdomains . Regulation PLAUR PLAU 18494499 1921836 Increased hnRNPC interaction with the uPAR mRNA 3'-UTR through phosphorylation of Y57 represents a novel mechanism by which *regulates* posttranscriptional uPAR mRNA turnover and cell surface [uPAR] expression . Regulation PLAUR PLAU 18564064 1959166 *Effects* of were independent of its proteolytic activity and required [uPAR] for both pro- and anti-apoptotic effects . Regulation PLAUR PLAU 19029002 2029308 To determine the *role* of in [uPAR] expression during ALI caused by sepsis . Regulation PLAUR PLAU 19123477 2037348 Plasmin(ogen) is activated on cell surfaces by , and is *regulated* by [uPAR] and plasminogen activator inhibitor-1 ( PAI-1 ) . Regulation PLAUR PLAU 8830783 385627 Taken together , these results suggest a dynamic regulatory *role* for PAI-1 and in [uPAR] mediated cell adhesion and release . Regulation PLAUR SELL 11290756 800672 To examine the *role* of in [uPAR] mediated signaling , uPAR was cross linked and intracellular Ca ( 2+ ) concentrations were measured by spectrofluorometry . Regulation PLAUR TLR7 21998707 2493791 However , it is unclear if [uPAR] has direct involvement in the *response* of inflammatory cells , such as neutrophils and macrophages , to stimulation . Regulation PLAUR TNF 14714609 1181707 To clarify the role of human gastric fibroblasts in acute inflammatory conditions such as gastric ulcer , the *effects* of interleukin (IL)-1beta and on the expression of uPA and [uPAR] , which were suggested to be associated with tissue remodeling , in gastric fibroblasts were investigated . Regulation PLCB1 GPR115 23295235 2769374 [Phospholipase C beta 1] ( PLCß1 ) is a downstream *effector* of signalling and holds central roles in reproductive physiology . Regulation PLCB1 GPR132 23295235 2769363 [Phospholipase C beta 1] ( PLCß1 ) is a downstream *effector* of signalling and holds central roles in reproductive physiology . Regulation PLCB1 GPR87 23295235 2769443 [Phospholipase C beta 1] ( PLCß1 ) is a downstream *effector* of signalling and holds central roles in reproductive physiology . Regulation PLCB2 F2R 12716374 1083721 These studies provide evidence that , in human platelets , both Galphaq and PLC-beta2 play a major role in *responses* to and PAR4 activation , and that [PLC-beta2] is required for the sustained Ca2+ rise upon thrombin activation . Regulation PLCD1 TNF 16618758 1551128 The data derived from the global genome analysis identified [phospholipase C-delta1] as an important *target* for receptors and revealed the critical role of TNF receptor signaling in the protection against adriamycin induced cardiotoxicity . Regulation PLCG1 ITGAL 19542227 2116380 Using membrane vesicles expressing the mouse class I major histocompatibility complex , i.e. Ld plus costimulatory ligands , i.e . B7-1 and intercellular adhesion molecule-1 along with 2C T cell receptor transgenic T cells , we investigated the *roles* of CD28 and ( lymphocyte function associated antigen-1 ) in the activation of [PLC-gamma1] and Ca2+ signaling . Regulation PLD1 FAS 12216112 986253 Differential *effects* of cross linking on [phospholipase D] activation and related lipid metabolism in Fas-resistant A20 cells . Regulation PLD1 FAS 12216112 986259 Using A20 cell lines that were resistant to Fas induced apoptosis , we investigated the differential *effects* of cross linking on [PLD] activity and sphingolipid metabolism . Regulation PLD1 FAS 16713231 1699956 The *effects* of various saturated and unsaturated on the proliferative response and [phospholipase D (PLD)] activity of rat thymocytes were investigated . Regulation PLD1 GPR115 12070761 956309 Heterotrimeric G proteins , protein kinase C ( PKC ) isoforms , protein tyrosine kinases , monomeric GTPases of the ADP-ribosylation factor (ARF) and Rho families , and as important cofactor phosphatidylinositol 4,5-bisphosphate ( PIP ( 2 ) ) seem to participate in the dependent *regulation* of [PLD] . Regulation PLD1 GPR132 12070761 956298 Heterotrimeric G proteins , protein kinase C ( PKC ) isoforms , protein tyrosine kinases , monomeric GTPases of the ADP-ribosylation factor (ARF) and Rho families , and as important cofactor phosphatidylinositol 4,5-bisphosphate ( PIP ( 2 ) ) seem to participate in the dependent *regulation* of [PLD] . Regulation PLD1 GPR87 12070761 956378 Heterotrimeric G proteins , protein kinase C ( PKC ) isoforms , protein tyrosine kinases , monomeric GTPases of the ADP-ribosylation factor (ARF) and Rho families , and as important cofactor phosphatidylinositol 4,5-bisphosphate ( PIP ( 2 ) ) seem to participate in the dependent *regulation* of [PLD] . Regulation PLD1 IL1B 10527453 654258 However , despite the ability of phorbol myristate acetate ( PMA ) to stimulate phospholipase D (PLD) and synthesis of phosphatidylethanol (PEt) in these cells , [PLD] activity was not *affected* by . Regulation PLD1 IL1B 10919268 717203 *regulates* [phospholipase D-1] expression in rat pancreatic beta-cells . Regulation PLD1 IL1B 10919268 717208 In conclusion , we have shown that the cytokine *regulates* [PLD1] expression in primary and clonal beta-cells . Regulation PLD1 TNF 8444187 213660 Subclones selected for resistance to TNF cytotoxicity did not show [phospholipase D] activation in *response* to . Regulation PLD2 FAS 12216112 986254 Differential *effects* of cross linking on [phospholipase D] activation and related lipid metabolism in Fas-resistant A20 cells . Regulation PLD2 FAS 12216112 986260 Using A20 cell lines that were resistant to Fas induced apoptosis , we investigated the differential *effects* of cross linking on [PLD] activity and sphingolipid metabolism . Regulation PLD2 FAS 16713231 1699957 The *effects* of various saturated and unsaturated on the proliferative response and [phospholipase D (PLD)] activity of rat thymocytes were investigated . Regulation PLD2 GPR115 12070761 956402 Heterotrimeric G proteins , protein kinase C ( PKC ) isoforms , protein tyrosine kinases , monomeric GTPases of the ADP-ribosylation factor (ARF) and Rho families , and as important cofactor phosphatidylinositol 4,5-bisphosphate ( PIP ( 2 ) ) seem to participate in the dependent *regulation* of [PLD] . Regulation PLD2 GPR132 12070761 956391 Heterotrimeric G proteins , protein kinase C ( PKC ) isoforms , protein tyrosine kinases , monomeric GTPases of the ADP-ribosylation factor (ARF) and Rho families , and as important cofactor phosphatidylinositol 4,5-bisphosphate ( PIP ( 2 ) ) seem to participate in the dependent *regulation* of [PLD] . Regulation PLD2 GPR87 12070761 956471 Heterotrimeric G proteins , protein kinase C ( PKC ) isoforms , protein tyrosine kinases , monomeric GTPases of the ADP-ribosylation factor (ARF) and Rho families , and as important cofactor phosphatidylinositol 4,5-bisphosphate ( PIP ( 2 ) ) seem to participate in the dependent *regulation* of [PLD] . Regulation PLD2 IL1B 10527453 654259 However , despite the ability of phorbol myristate acetate ( PMA ) to stimulate phospholipase D (PLD) and synthesis of phosphatidylethanol (PEt) in these cells , [PLD] activity was not *affected* by . Regulation PLD2 IL1B 10919268 717206 RINm5F cells , but not primary beta-cells , expressed [PLD2] , and the expression of this gene was not *affected* by . Regulation PLD2 TNF 8444187 213661 Subclones selected for resistance to TNF cytotoxicity did not show [phospholipase D] activation in *response* to . Regulation PLD3 FAS 12216112 986249 Differential *effects* of cross linking on [phospholipase D] activation and related lipid metabolism in Fas-resistant A20 cells . Regulation PLD3 FAS 12216112 986255 Using A20 cell lines that were resistant to Fas induced apoptosis , we investigated the differential *effects* of cross linking on [PLD] activity and sphingolipid metabolism . Regulation PLD3 FAS 16713231 1699952 The *effects* of various saturated and unsaturated on the proliferative response and [phospholipase D (PLD)] activity of rat thymocytes were investigated . Regulation PLD3 GPR115 12070761 955937 Heterotrimeric G proteins , protein kinase C ( PKC ) isoforms , protein tyrosine kinases , monomeric GTPases of the ADP-ribosylation factor (ARF) and Rho families , and as important cofactor phosphatidylinositol 4,5-bisphosphate ( PIP ( 2 ) ) seem to participate in the dependent *regulation* of [PLD] . Regulation PLD3 GPR132 12070761 955926 Heterotrimeric G proteins , protein kinase C ( PKC ) isoforms , protein tyrosine kinases , monomeric GTPases of the ADP-ribosylation factor (ARF) and Rho families , and as important cofactor phosphatidylinositol 4,5-bisphosphate ( PIP ( 2 ) ) seem to participate in the dependent *regulation* of [PLD] . Regulation PLD3 GPR87 12070761 956006 Heterotrimeric G proteins , protein kinase C ( PKC ) isoforms , protein tyrosine kinases , monomeric GTPases of the ADP-ribosylation factor (ARF) and Rho families , and as important cofactor phosphatidylinositol 4,5-bisphosphate ( PIP ( 2 ) ) seem to participate in the dependent *regulation* of [PLD] . Regulation PLD3 IL1B 10527453 654254 However , despite the ability of phorbol myristate acetate ( PMA ) to stimulate phospholipase D (PLD) and synthesis of phosphatidylethanol (PEt) in these cells , [PLD] activity was not *affected* by . Regulation PLD3 TNF 8444187 213656 Subclones selected for resistance to TNF cytotoxicity did not show [phospholipase D] activation in *response* to . Regulation PLD4 FAS 12216112 986250 Differential *effects* of cross linking on [phospholipase D] activation and related lipid metabolism in Fas-resistant A20 cells . Regulation PLD4 FAS 12216112 986256 Using A20 cell lines that were resistant to Fas induced apoptosis , we investigated the differential *effects* of cross linking on [PLD] activity and sphingolipid metabolism . Regulation PLD4 FAS 16713231 1699953 The *effects* of various saturated and unsaturated on the proliferative response and [phospholipase D (PLD)] activity of rat thymocytes were investigated . Regulation PLD4 GPR115 12070761 956030 Heterotrimeric G proteins , protein kinase C ( PKC ) isoforms , protein tyrosine kinases , monomeric GTPases of the ADP-ribosylation factor (ARF) and Rho families , and as important cofactor phosphatidylinositol 4,5-bisphosphate ( PIP ( 2 ) ) seem to participate in the dependent *regulation* of [PLD] . Regulation PLD4 GPR132 12070761 956019 Heterotrimeric G proteins , protein kinase C ( PKC ) isoforms , protein tyrosine kinases , monomeric GTPases of the ADP-ribosylation factor (ARF) and Rho families , and as important cofactor phosphatidylinositol 4,5-bisphosphate ( PIP ( 2 ) ) seem to participate in the dependent *regulation* of [PLD] . Regulation PLD4 GPR87 12070761 956099 Heterotrimeric G proteins , protein kinase C ( PKC ) isoforms , protein tyrosine kinases , monomeric GTPases of the ADP-ribosylation factor (ARF) and Rho families , and as important cofactor phosphatidylinositol 4,5-bisphosphate ( PIP ( 2 ) ) seem to participate in the dependent *regulation* of [PLD] . Regulation PLD4 IL1B 10527453 654255 However , despite the ability of phorbol myristate acetate ( PMA ) to stimulate phospholipase D (PLD) and synthesis of phosphatidylethanol (PEt) in these cells , [PLD] activity was not *affected* by . Regulation PLD4 TNF 8444187 213657 Subclones selected for resistance to TNF cytotoxicity did not show [phospholipase D] activation in *response* to . Regulation PLD5 FAS 12216112 986251 Differential *effects* of cross linking on [phospholipase D] activation and related lipid metabolism in Fas-resistant A20 cells . Regulation PLD5 FAS 12216112 986257 Using A20 cell lines that were resistant to Fas induced apoptosis , we investigated the differential *effects* of cross linking on [PLD] activity and sphingolipid metabolism . Regulation PLD5 FAS 16713231 1699954 The *effects* of various saturated and unsaturated on the proliferative response and [phospholipase D (PLD)] activity of rat thymocytes were investigated . Regulation PLD5 GPR115 12070761 956123 Heterotrimeric G proteins , protein kinase C ( PKC ) isoforms , protein tyrosine kinases , monomeric GTPases of the ADP-ribosylation factor (ARF) and Rho families , and as important cofactor phosphatidylinositol 4,5-bisphosphate ( PIP ( 2 ) ) seem to participate in the dependent *regulation* of [PLD] . Regulation PLD5 GPR132 12070761 956112 Heterotrimeric G proteins , protein kinase C ( PKC ) isoforms , protein tyrosine kinases , monomeric GTPases of the ADP-ribosylation factor (ARF) and Rho families , and as important cofactor phosphatidylinositol 4,5-bisphosphate ( PIP ( 2 ) ) seem to participate in the dependent *regulation* of [PLD] . Regulation PLD5 GPR87 12070761 956192 Heterotrimeric G proteins , protein kinase C ( PKC ) isoforms , protein tyrosine kinases , monomeric GTPases of the ADP-ribosylation factor (ARF) and Rho families , and as important cofactor phosphatidylinositol 4,5-bisphosphate ( PIP ( 2 ) ) seem to participate in the dependent *regulation* of [PLD] . Regulation PLD5 IL1B 10527453 654256 However , despite the ability of phorbol myristate acetate ( PMA ) to stimulate phospholipase D (PLD) and synthesis of phosphatidylethanol (PEt) in these cells , [PLD] activity was not *affected* by . Regulation PLD5 TNF 8444187 213658 Subclones selected for resistance to TNF cytotoxicity did not show [phospholipase D] activation in *response* to . Regulation PLD6 FAS 12216112 986252 Differential *effects* of cross linking on [phospholipase D] activation and related lipid metabolism in Fas-resistant A20 cells . Regulation PLD6 FAS 12216112 986258 Using A20 cell lines that were resistant to Fas induced apoptosis , we investigated the differential *effects* of cross linking on [PLD] activity and sphingolipid metabolism . Regulation PLD6 FAS 16713231 1699955 The *effects* of various saturated and unsaturated on the proliferative response and [phospholipase D (PLD)] activity of rat thymocytes were investigated . Regulation PLD6 GPR115 12070761 956216 Heterotrimeric G proteins , protein kinase C ( PKC ) isoforms , protein tyrosine kinases , monomeric GTPases of the ADP-ribosylation factor (ARF) and Rho families , and as important cofactor phosphatidylinositol 4,5-bisphosphate ( PIP ( 2 ) ) seem to participate in the dependent *regulation* of [PLD] . Regulation PLD6 GPR132 12070761 956205 Heterotrimeric G proteins , protein kinase C ( PKC ) isoforms , protein tyrosine kinases , monomeric GTPases of the ADP-ribosylation factor (ARF) and Rho families , and as important cofactor phosphatidylinositol 4,5-bisphosphate ( PIP ( 2 ) ) seem to participate in the dependent *regulation* of [PLD] . Regulation PLD6 GPR87 12070761 956285 Heterotrimeric G proteins , protein kinase C ( PKC ) isoforms , protein tyrosine kinases , monomeric GTPases of the ADP-ribosylation factor (ARF) and Rho families , and as important cofactor phosphatidylinositol 4,5-bisphosphate ( PIP ( 2 ) ) seem to participate in the dependent *regulation* of [PLD] . Regulation PLD6 IL1B 10527453 654257 However , despite the ability of phorbol myristate acetate ( PMA ) to stimulate phospholipase D (PLD) and synthesis of phosphatidylethanol (PEt) in these cells , [PLD] activity was not *affected* by . Regulation PLD6 TNF 8444187 213659 Subclones selected for resistance to TNF cytotoxicity did not show [phospholipase D] activation in *response* to . Regulation PLG GAB3 7890006 299172 The *effect* of the on thrombin and [plasmin] generation following liver resection in cirrhotic patients was studied . Regulation PLG IL1B 12375736 996726 *regulates* cellular proliferation , prostaglandin E2 synthesis , [plasminogen] activator activity , osteocalcin production , and bone resorptive activity of the mouse calvarial bone cells . Regulation PLG IL1B 12375736 996727 Furthermore , [plasminogen] activator activity of the mouse osteoblast was positively *affected* by in a dose dependent manner over the dosage range of 0.01 ng-2 ng/mL with a maximal effect being observed at 2 ng/mL . Regulation PLG IL1B 2302203 127733 The *effects* of recombinant human on cellular proliferation and the production of prostaglandin E2 , [plasminogen] activator , osteocalcin and alkaline phosphatase by osteoblast-like cells derived from human bone . Regulation PLG MFI2 15936756 1433975 In the present study , the *effect* of membrane bound ( mMTf ) , also known as human melanoma antigen p97 , on cell surface [plasminogen] binding and activation was investigated by using Chinese Hamster Ovary ( CHO ) cells transfected with full-length melanotransferrin (MTf) cDNA and SK-MeL-28 melanoma cells . Regulation PLG PLAT 16524621 1665690 Anti-annexin 2 antibody and transfection of annexin 2 small interfering RNA into these carcinoma cells significantly inhibited *dependent* [plasmin] generation . Regulation PLG PLAT 20079732 2225630 Breast cancer cell surface annexin II induces cell migration and neoangiogenesis via *dependent* [plasmin] generation . Regulation PLG PLAT 20079732 2225632 Silencing of annexin II gene in MDA-MB231 cells abolished tPA binding therefore inhibited *dependent* [plasmin] generation . Regulation PLG PLAT 22238323 2579932 Notably , plasmin and tPA activities , as well as *dependent* generation of [plasmin] in solution , are not decreased in the presence of Aß ( 42 ) . Regulation PLG PLAT 22318336 2575926 Prior reports demonstrated that at least one herpesvirus expresses surface annexin A2 ( A2 ) , a cofactor for *dependent* activation of [plasminogen] to plasmin . Regulation PLG PLAT 22974122 2713589 Binding of ( t-PA ) and Pgn to fibrin *regulates* [plasmin] generation , but there is no consistent , quantitative understanding of the individual contribution of t-PA finger and kringle 2 domains to the regulation of fibrinolysis . Regulation PLG PLAT 2499946 111978 *Effects* of , urokinase ( u-PA ) and their combinations on [plasminogen activation rate (PAR)] in plasma , in vitro were investigated . Regulation PLG PLAT 3127394 90470 Plasminogen activator inhibitor-2 ( PAI-2 ) is a serine protease inhibitor that *regulates* [plasmin] generation by inhibiting urokinase and . Regulation PLG PLAT 8496923 219644 These water-soluble cyclopeptides behave as time dependent inhibitors of bovine trypsin and human urokinase ( u-PA ) but have no effect on and no or poor *effect* on [plasmin] and thrombin . Regulation PLG PLAU 10340907 616214 receptor ( uPAR ) is functionally *involved* in the cell surface activation ( i.e. , cleavage ) of [plasminogen] . Regulation PLG PLAU 10496343 647204 The receptor ( uPAR ) *plays* a critical role in urokinase mediated [plasminogen] activation and thereby in the process leading to invasion and metastasis . Regulation PLG PLAU 11016879 736530 The generation of the broad specificity serine protease [plasmin] in the pericellular environment is *regulated* by binding of the ( uPA ) to its specific glycosylphosphatidylinositol (GPI) anchored cell-surface receptor , uPAR . Regulation PLG PLAU 11580291 865458 The high-affinity interaction between ( uPA ) and its glycolipid anchored receptor ( uPAR ) *plays* an important role in pericellular [plasminogen] activation . Regulation PLG PLAU 12189157 997757 The *role* of and its receptor ( CD87 ) in [plasminogen (Plg)] activation , cell adhesion , and chemotaxis is well established ; Regulation PLG PLAU 16525582 1531587 We studied whether the binding of to integrin alpha v beta 3 through the kringle domain *plays* a role in [plasminogen] activation . Regulation PLG PLAU 16525582 1531589 These results suggest that binding to integrins through the kringle domain *plays* an important role in both [plasminogen] activation and uPA induced intracellular signaling . Regulation PLG PLAU 16676075 1558934 Although the *roles* of and PAI-1 in [plasmin] generation and the degradation of fibrin are well known , recent evidence also suggests that they can participate in acute inflammatory conditions that involve neutrophil activation . Regulation PLG PLAU 17606760 1792591 The generation of [plasmin] *involved* expression of ( uPA ) and its receptor ( uPAR ) at the surface of EMPs and was further increased by their ability to bind exogenous uPA on uPAR . Regulation PLG PLAU 17692534 1794381 ( uPA ) *plays* a crucial role in the regulation of [plasminogen] activation , tumor cell adhesion and migration . Regulation PLG PLAU 22013113 2503310 In congenital heart block ( CHB ) , binding of maternal anti-SSA/Ro Abs to fetal apoptotic cardiocytes impairs their removal by healthy cardiocytes and increases receptor (uPAR) *dependent* [plasmin] activation . Regulation PLG PLAU 2307845 129935 Mononuclear phagocytes *regulate* the generation of [plasmin] by secreting ( uPA ) and plasminogen activator inhibitor-2 ( PAI-2 ) . Regulation PLG PLAU 8050560 267527 [Plasminogen] activation is *regulated* by the interaction between ( uPA ) and its specific glycolipid anchored cell surface receptor ( uPAR ) . Regulation PLG PLAU 9287983 452413 *regulates* [plasmin] generation from plasminogen . Regulation PLG PLAU 9425170 481580 Receptor independent *role* of in pericellular [plasmin] and matrix metalloproteinase proteolysis during vascular wound healing in mice . Regulation PLG PLAU 9989951 597182 The receptor ( uPAR ) *plays* a critical role in the regulation of cell-surface [plasminogen] activation in several physiological and pathological conditions . Regulation PLG SRGN 12576095 1057986 One fragment possessed a high degree of homology with Mus musculus hnRNP-L ( protein L ) mRNA ( GenBank # AB009392 ) ( termed : [PLG] *regulated* gene 1 ) . Regulation PLG TNF 1311745 179045 We determine how recombinant interferon-gamma (IFN) and *regulate* [plasminogen] activation in monoblast-like U937 cells and normal human monocytes . Regulation PLG TNF 14534369 1165048 and troglitazone *regulate* [plasminogen] activator inhibitor type 1 production through extracellular signal regulated kinase- and nuclear factor-kappaB dependent pathways in cultured human umbilical vein endothelial cells . Regulation PLG TNF 19638263 2143132 mediated plasminogen activation on neutrophils is *involved* in the high [plasmin] activity in mammary secretion of drying-off cows . Regulation PLG TNF 2324095 132177 We examined the role of two different second messenger systems in the *regulation* of [plasminogen] activator inhibitor , type 2 ( PAI-2 ) induction by in SK-MEL-109 melanoma cells . Regulation PLG TNF 8088923 271675 We have investigated the *effect* of on the synthesis and/or steady-state mRNA levels of collagen , alkaline phosphatase (ALP) , [plasminogen activators (PAs)] and their inhibitor PAI-1 , and collagenases ( MMPs ) and their inhibitor TIMP-1 by human osteoblastic , HOS TE85 , cells in monolayer cultures . Regulation PLG TNF 8898893 393154 Molecular mechanisms governing mediated *regulation* of [plasminogen-activator] inhibitor type-2 gene expression . Regulation PLG TNF 9861174 555833 It has been hypothesized that [plasmin] *regulates* these two responses by activating collagenases and , respectively . Regulation PLIN1 FAS 23606724 2795227 To understand how *regulate* [Plin] genes , we used specific activators and antagonists against PPARs , Plin promoter reporter assays , chromatin immunoprecipitation , siRNA , and animal models . Regulation PLIN1 TNF 22949029 2693380 did not *affect* [perilipin] , HSL , or phosphodiesterase-3B mass but paradoxically suppressed adipose tissue triglyceride lipase expression , and this effect was blocked by DEX . Regulation PLK1 FOXO1 18356527 1887684 In proliferating cells , Cdk1 induced FOXO1 Ser249 phosphorylation at the G2/M phase of the cell cycle , resulting in *dependent* expression of the mitotic regulator [Polo-like kinase (Plk)] . Regulation PLK1 STK39 18083840 1837932 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation PLN IL1B 9314830 455703 Studies performed in the presence of second-messenger inhibitors showed that the *effect* of on [phospholamban] transcript levels was blocked by dexamethasone , was insensitive to inhibitors of iNOS , cyclooxygenase , or tyrosine kinases , but was enhanced by the addition of the protein kinase inhibitor staurosporine . Regulation PLOD1 CTGF 24192939 2897118 [PLOD1] and PLOD3 were not *affected* by either TGF-ß or . Regulation PLOD2 CTGF 24192939 2897117 For this study , we investigate if transforming growth factor-beta ( TGF-ß ) and *regulate* procollagen-lysine , 2-oxoglutarate 5-dioxygenase 2 ( PLOD2 ) ( gene encoding LH2b ) and [LH2b] expression differently in osteoarthritic human synovial fibroblasts ( hSF ) . Regulation PLOD3 CTGF 24192939 2897119 PLOD1 and [PLOD3] were not *affected* by either TGF-ß or . Regulation PLS3 SMN2 22496553 2583679 This indicates that *affects* [PLS3] protein production . Regulation PML TP63 16007146 1465539 Here we present data indicating that ( i ) the promyelocytic leukaemia protein (PML) physically interacts with p63 , ( ii ) is localized into the PML nuclear-bodies (PML-NBs) in vivo , and ( iii ) [PML] *regulates* p63 transcriptional activity . Regulation PMS1 IL1B 15103492 1258364 Therefore , IL-1beta induces both a pro- and an anti-inflammatory response in pediatric PMs , whereas adult [PMs] produce only pro-inflammatory cytokines in *response* to . Regulation PMS1 TNF 9793792 542856 By contrast , the peritoneal cavity had greatly increased local LPS and TNF-alpha levels and a diminished [PMs] *response* to LPS . Regulation PMS2 IL1B 15103492 1258365 Therefore , IL-1beta induces both a pro- and an anti-inflammatory response in pediatric PMs , whereas adult [PMs] produce only pro-inflammatory cytokines in *response* to . Regulation PMS2 TNF 9793792 542857 By contrast , the peritoneal cavity had greatly increased local LPS and levels and a diminished [PMs] TNF-alpha *response* to LPS . Regulation PNMA3 IL1B 12356684 993995 The stimulatory *effects* of on [MASP1/3] and MASP2 gene expression were abolished by the simultaneous presence of IL-6 . Regulation PODXL ATF3 21900211 2506578 In addition , *regulation* of LIF , CLDN1 , SERPINE2 , HSD17B2 , ITGA7 and [PODXL] by mediated the increased proliferation capacity of CAFs . Regulation PODXL CTGF 21602138 2435842 To detect the *effect* of on [podocalyxin] expression in mouse podocytes exposed to high glucose in vitro and explore the possible pathway involved . Regulation PODXL PAN2 11274237 797606 T-SV 40 immortalized human glomerular epithelial cells were used to study 's *effects* on alpha3beta1 expression , as well as that of [podocalyxin] and the slit diaphragm component ZO-1 . Regulation PODXL PAN3 11274237 797607 T-SV 40 immortalized human glomerular epithelial cells were used to study 's *effects* on alpha3beta1 expression , as well as that of [podocalyxin] and the slit diaphragm component ZO-1 . Regulation PODXL SP1 16684343 1575506 *Role* of and CpG methylation on the regulation of the human [podocalyxin] gene promoter . Regulation PODXL TP53 18656241 2008790 Although podocalyxin-like protein 1 did not correlate with or Wilms tumor suppressor 1 , known *regulators* of [podocalyxin-like protein 1] , we could demonstrate demethylated CpG islands in the podocalyxin-like protein 1 promoter in small cell lung cancer , indicating epigenetic regulation . Regulation PODXL VDR 23548800 2714196 Furthermore , specifically *regulates* [podocalyxin] expression by bounding to a site upstream of the podocalyxin promoter . Regulation PODXL WT1 11719225 883665 *regulates* the expression of the major glomerular podocyte membrane protein [Podocalyxin] . Regulation PODXL WT1 15155752 1273261 [PODXL] is also transcriptionally *regulated* by and has roles in cell adhesion and anti-adhesion . Regulation POLDIP2 EMP1 21811066 2490387 The [p38] signaling *involves* generation induced by indoxyl sulfate and is effectively suppressed by clopidogrel . Regulation POLDIP2 EPHB2 9822700 548870 Moreover , whereas inhibition of had no *effect* on [p38] activity , p38 inhibition consistently increased MHV-3 induced ERK activity . Regulation POLDIP2 LBP 11134043 794925 Here we show that secretion of tumor necrosis factor-alpha induced by Treponema culture supernatants and extracted LTA was paralleled by an *dependent* phosphorylation of mitogen activated protein kinases ( MAPKs ) p42 and p44 , and [p38] , as well as the stress activated protein kinases c-Jun N-terminal kinases 1 and 2 . Regulation POLDIP2 MAP2K6 21354263 2420611 p38ß induced BNP transcription was diminished by mutation of GATA-4 binding site , whereas overexpression of , an upstream *regulator* of p38a and [p38ß] , activated BNP transcription through both GATA-4 and AP-1 . Regulation POLDIP2 TNF 15087472 1258136 Stimulatory *effects* of on neuropeptide gene expression and release appeared to be mediated through the type 2 TNF-alpha receptor , and required activation of ERK 1/2 and [p38] , but not Janus kinase , MAPKs . Regulation POLDIP2 TNF 16813528 1580731 In addition , activation of p38 was blocked in rats treated with TNF-alpha antagonist , suggesting a *role* of in [p38] activation . Regulation POLDIP2 TNF 20004242 2199800 We show that MKK3 and MKK6 are both essential for the activation of p38gamma and p38beta induced by environmental stress , whereas MKK6 is the major [p38gamma] activator in *response* to . Regulation POLDIP2 TNFSF10 21248767 2402858 Differential *regulation* of extracellular signal regulated kinase and [p38] activation by is also observed . Regulation POLDIP3 RAB31 12526085 1028218 guanine nucleotide dissociation inhibitor ( RabGDI ) , which dissociates Rab proteins from SVs , did not *affect* phosphorylation of [p46] . Regulation POLDIP3 TNF 9371818 466185 In addition , both the [p46] and p54 JNK/SAPK isoforms were phosphorylated on their TPY motif in *response* to stimulation as reflected by immunoblotting with a phospho-specific antibody that recognizes both kinases . Regulation POMC IL1B 7538634 306853 Differential cellular *regulation* of [pro-opiomelanocortin] by and corticotropin releasing hormone . Regulation PON1 TNF 14511766 1146690 To clarify this point , we evaluated the transcriptional *regulation* of [PON1] gene by IL-1beta , IL-6 and in HepG2 cells using luciferase reporter gene assay . Regulation PON2 PLAU 18436804 1926422 In the present study we investigated the *effect* of on macrophage [PON2] expression in relation to cellular oxidative stress . Regulation PON2 PLAU 19497963 2128444 The increase in macrophage [PON2] mRNA levels in *response* to was shown to depend on PON2 gene promoter activation and mRNA transcription . Regulation POSTN TNF 24370179 2895248 No stimulatory *effect* of or P. gingivalis LPS on the production of [periostin] was observed . Regulation POU5F1 CCND1 25128069 2957240 Whereas , suppression of did not *affect* [OCT4] expression , suggesting that OCT4 regulates CCND1 expression by activating the CCND1 promoter and subsequently promoting cell cycle progression . Regulation POU5F1 ZFP57 19740739 2158354 We show that binds to the Oct4 promoter and directly *regulates* [Oct4] expression . Regulation PPA1 AXIN2 21814488 2462861 Third , [Ppa-LIN-18/Ryk] signaling *involves* and ß-catenin and Ppa-axl-1/Axin is epistatic to Ppa-lin-18/Ryk . Regulation PPA2 AXIN2 21814488 2462855 Third , [Ppa-LIN-18/Ryk] signaling *involves* and ß-catenin and Ppa-axl-1/Axin is epistatic to Ppa-lin-18/Ryk . Regulation PPARA EPHB2 15149321 1248371 activity positively *regulated* [PPAR] activation . Regulation PPARA TNF 17034877 1654315 The latter response is related to the suppressive *effects* of on peroxisomal function and on [PPARalpha] . Regulation PPARA TNF 19067734 2018092 However , co-administration of ascorbic acid prevented the *effect* of both on [PPAR-alpha] and PPAR-gamma . Regulation PPARA TNF 22956307 2726588 Direct *effect* of on [PPAR-d] expression was also characterized in RMC cell . Regulation PPARA TNF 9256257 447929 In contrast , the mRNA for beta-actin was markedly increased implying that the *effect* of on [PPAR-alpha] and the peroxisomal mRNAs is highly selective . Regulation PPARA TP63 19458633 2128292 Distinct [PPARalpha] transcripts are differentially *regulated* by , indicating a bimodal action in promoter and/or transcription start specification . Regulation PPARD FOXO1 24362249 2905574 [PPAR-delta] also *regulates* glucose metabolism and mitochondrial biogenesis by inducing and PGC1-alpha . Regulation PPARD HSD11B2 15591138 1368902 Given that PPAR delta-null mice exhibited placental defects and consequent intrauterine growth restriction , the present study was undertaken to examine the hypothesis that [PPAR delta] *regulates* human placental function in part by targeting <11beta-HSD2> . Regulation PPARG CCND1 15486348 1366942 In addition to curcumin reduction of the level of phosphorylated PPARgamma , inhibition of expression *played* a major and significant role in curcumin stimulation of [PPARgamma] activity in Moser cells . Regulation PPARG EPHB2 11733495 904461 Taken together , these results indicate that PPARgamma is targeted to the ubiquitin-proteasome pathway for degradation under basal conditions and that IFNgamma leads to an increased targeting of PPARgamma to the ubiquitin-proteasome system in a process that is affected by *regulated* serine phosphorylation of [PPARgamma] proteins . Regulation PPARG EPHB2 12475986 1056005 In addition , TGZ induces *dependent* phosphorylation of [PPAR gamma] , resulting in the down-regulation of PPAR gamma activity . Regulation PPARG EPHB2 12758056 1090988 This temporal separation of ERK activation from the affected PPARgamma1 expression suggests that does not *act* directly on either [PPARgamma1] transcription or receptor function . Regulation PPARG EPHB2 15149321 1248354 [PPAR gamma] activity is *regulated* by extracellular signal regulated protein kinase ( ERK ) , mitogen activated protein (MAP) kinase , and PPAR gamma ligands have varying effects on activity of . Regulation PPARG EPHB2 15149321 1248369 The *role* of and phosphorylation in [PPAR gamma] activation were studied , as were the effects of PPAR agonists on ERK activation and cell proliferation . Regulation PPARG EPHB2 16945329 1615525 Pretreatment with bisindolylmaleimide I or NAC blocked TPA induced phosphorylation of extracellular signal regulated kinase ( ERK ) , suggesting that mediated signaling is also *involved* in the induction of [PPARgamma] . Regulation PPARG EPHB2 18204460 1863783 These results indicate that Dok1 promotes adipocyte hypertrophy by counteracting the inhibitory *effect* of on [PPAR-gamma] and may thus confer predisposition to diet induced obesity . Regulation PPARG EPHB2 19243475 2271834 Serum regulates adipogenesis of mesenchymal stem cells via *dependent* [PPARgamma] expression and phosphorylation . Regulation PPARG FOXO1 16670091 1583508 We studied the *effects* of on human [PPARgamma] gene expression in primary rat adipocytes and found that both genes are endogenously expressed . Regulation PPARG IL1B 17386086 1760278 This study was undertaken to investigate the quantitative expression and distribution of PPARgamma in normal and OA cartilage and to evaluate the *effect* of , a prominent cytokine in OA , on [PPARgamma] expression in cultured chondrocytes . Regulation PPARG MAP2K6 19243475 2271840 Serum regulates adipogenesis of mesenchymal stem cells via *dependent* [PPARgamma] expression and phosphorylation . Regulation PPARG TNF 12213872 985749 Although an autocrine *effect* of the enhanced secretion seen with increasing obesity might play a role in the changes in [PPARgamma1] , this would not provide an explanation for the different relationship of PPARgamma2 to adiposity . Regulation PPARG TNF 14646597 1173198 Compared with adipogenesis , however , SP600125 , a chemical JNK inhibitor hardly relieved *effect* on [PPARgamma] expression whereas S32A/S36A mutant of IkappaBalpha considerably recovered PPARgamma expression , indicating that two signal mediators exploit separable main routes to achieve reduced adipogenesis . Regulation PPARG TNF 15284209 1302580 To clarify molecular mechanisms of TNFalpha- mediated PPARgamma2 down-regulation , we here examined the *effect* of on transcription regulation of [PPARgamma2] gene expression during the early stage of adipocyte differentiation . Regulation PPARG TNF 15563986 1341372 Overexpression of wild type PKCzeta magnified and accelerated the *effect* of and C6-ceramide on [PPARgamma] mRNA levels , whereas overexpression of dominant negative PKCzeta abolished the effect . Regulation PPARG TNF 18612822 2028039 Saccharomyces boulardii blocked *regulation* of [PPAR-gamma] and IL-8 through disruption of TNF-alpha mediated nuclear factor kappa B (NF-kappaB) activation . Regulation PPARG TNF 18655773 1947859 [PPARgamma] activity is *regulated* by at pre-translational and post-translational levels . Regulation PPARG TNF 19067734 2018093 However , co-administration of ascorbic acid prevented the *effect* of both on PPAR-alpha and [PPAR-gamma] . Regulation PPARG TNF 19067734 2018101 Coenzyme Q10 partially attenuated the *effect* of on [PPAR-gamma] but did not alter its effect on PPAR-alpha . Regulation PPARG ZFP57 20200519 2229645 *regulates* [Pparg] expression , in part , through amplification of the BMP signalling pathway , an effect dependent on the SMAD binding capacity of Zfp423 . Regulation PPARGC1A FOXO1 16527841 1561695 The expression of [PGC-1alpha] in muscle is *regulated* by myocyte enhancer factor 2 and , two transcription factors implicated in terminal muscle differentiation . Regulation PPBP IL1A 23136963 2710748 Moreover , in P phase CTVT , while and TGF-ß had no obvious *effect* on [CXCL7] expression , IL-6 was found significantly to reduce CXCL7 expression in a dose dependent manner . Regulation PPBP IL6 23136963 2710746 Now we intend to determine the expression pattern of CXCL7 and the *role* of in [CXCL7] induction during spontaneous progressive ( P ) and regressive ( R ) phases in canine transmissible venereal tumor ( CTVT ) . Regulation PPP1CC STK39 18083840 1837947 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation PPP1R12A EPHB2 15665049 1402426 Alpha1-adrenoceptor mediated phosphorylation of [MYPT-1] and CPI-17 in the uterine artery : *role* of . Regulation PPP1R12A STK39 10924361 718275 Phosphorylation of CPI-17 by protein kinase N (PKN) , a fatty acid- and Rho activated , and its *effect* on smooth muscle [myosin phosphatase] activity were investigated . Regulation PPP1R14A EPHB2 15665049 1402425 Alpha1-adrenoceptor mediated phosphorylation of MYPT-1 and [CPI-17] in the uterine artery : *role* of . Regulation PPP1R14A EPHB2 15665049 1402445 PD-098059 inhibited phosphorylation of ( 44/42 ) and the initial peak phosphorylation of MYPT-1/Thr ( 850 ) but did not *affect* [CPI-17/Thr] ( 38 ) phosphorylation . Regulation PPP1R1A CDK5 17400554 1741951 *Regulation* of [protein phosphatase inhibitor-1] by . Regulation PPP1R1B RARB 16026464 1435713 isoform-specific *regulation* of [DARPP-32] gene expression : an ectopic expression study in the developing rat telencephalon . Regulation PPP1R1B RARB 16026464 1435717 Our study suggests that signaling may *regulate* [DARPP-32] gene expression by an isoform-specific mechanism in developing telencephalic neurons . Regulation PPP2CA EPHB2 12937125 1132904 In vitro , these tau phospho-epitopes can be phosphorylated by the kinases and JNK , and the kinases themselves are negatively *regulated* by [PP2A] . Regulation PPP2CA EPHB2 23775084 2820332 Our results demonstrate that [PP2A] *regulates* DNA methylation by influencing the phosphorylation of . Regulation PPP2CA MAP2K6 23775084 2820338 Our results demonstrate that [PP2A] *regulates* DNA methylation by influencing the phosphorylation of . Regulation PPP2CA TNF 17872368 1823590 did not *affect* total cell [Cx43-PP2A] catalytic subunit interaction , but it did induce PP2A catalytic subunit recruitment to the Triton X-100 insoluble subcellular fraction , in which Cx43-gap junction plaques are recovered . Regulation PPP2CA TNF 8665940 369042 Cell-permeable ceramide analogs mimicked the *effect* on MAPK inhibition and [PP-2A] activation . Regulation PPP2R1A EPHB2 12937125 1132905 In vitro , these tau phospho-epitopes can be phosphorylated by the kinases and JNK , and the kinases themselves are negatively *regulated* by [PP2A] . Regulation PPP2R1A EPHB2 23775084 2820340 Our results demonstrate that [PP2A] *regulates* DNA methylation by influencing the phosphorylation of . Regulation PPP2R1A MAP2K6 23775084 2820346 Our results demonstrate that [PP2A] *regulates* DNA methylation by influencing the phosphorylation of . Regulation PPP2R1A TNF 17872368 1823591 did not *affect* total cell [Cx43-PP2A] catalytic subunit interaction , but it did induce PP2A catalytic subunit recruitment to the Triton X-100 insoluble subcellular fraction , in which Cx43-gap junction plaques are recovered . Regulation PPP2R1A TNF 8665940 369043 Cell-permeable ceramide analogs mimicked the *effect* on MAPK inhibition and [PP-2A] activation . Regulation PPP2R2B EPHB2 12937125 1132906 In vitro , these tau phospho-epitopes can be phosphorylated by the kinases and JNK , and the kinases themselves are negatively *regulated* by [PP2A] . Regulation PPP2R2B EPHB2 23775084 2820348 Our results demonstrate that [PP2A] *regulates* DNA methylation by influencing the phosphorylation of . Regulation PPP2R2B MAP2K6 23775084 2820354 Our results demonstrate that [PP2A] *regulates* DNA methylation by influencing the phosphorylation of . Regulation PPP2R2B TNF 17872368 1823592 did not *affect* total cell [Cx43-PP2A] catalytic subunit interaction , but it did induce PP2A catalytic subunit recruitment to the Triton X-100 insoluble subcellular fraction , in which Cx43-gap junction plaques are recovered . Regulation PPP2R2B TNF 8665940 369044 Cell-permeable ceramide analogs mimicked the *effect* on MAPK inhibition and [PP-2A] activation . Regulation PPP3CA CAPN8 14627704 1201062 This study established a molecular link between calpain and calcineurin , thereby demonstrating a new mechanism for proteolytical *regulation* of [calcineurin] by in response to certain pathological states . Regulation PPP3CA CAPN8 17593948 1764754 Recent studies have demonstrated an interplay between calpain and calcineurin , in which can directly *regulate* [calcineurin] activity through proteolysis in glutamate stimulated neurons in culture and in vivo . Regulation PPP3CA CAPN8 18445709 1938633 These data suggest that activation suppresses NMDAR function via proteolytic cleavage of NR2 subunits in vitro and in vivo , and the susceptibility of NMDARs to calpain cleavage is *controlled* by PSD-95 and [calcineurin] . Regulation PPP3CA CAPN8 24987545 2947994 [Calcineurin] activity is *regulated* by , a cysteine protease present in the nucleus . Regulation PPP3CA CAPN8 24987545 2948078 Thus , we examined whether *regulates* [calcineurin] in renal tubule nuclei . Regulation PPP3CA PGC 21945104 2554964 Whether [calcineurin] can *control* expression has been proposed but is still controversial . Regulation PPP3CA RCAN1 12809556 1120694 Taking all these results into consideration we suggest that phosphorylation of is *involved* in the regulation of the phosphatase activity of [calcineurin] and can therefore act as a modulator of calcineurin dependent cellular pathways . Regulation PPP3CA RCAN1 16649988 1557396 While can *regulate* [calcineurin] and GSK-3beta , it has also been shown that calcineurin and GSK-3beta can regulate RCAN1s . Regulation PPP3CA RCAN1 17610901 1786685 Down syndrome candidate region 1-like 1 ( DSCR1-L1 ) mimics the inhibitory *effects* of on [calcineurin] signaling in endothelial cells and inhibits angiogenesis . Regulation PPP3CA RCAN1 18045910 1832894 ( RCAN1/MCIP1/DSCR1 ) *regulates* the calmodulin dependent phosphatase [calcineurin] . Regulation PPP3CA RCAN1 19136967 2032062 The calcium activated protein phosphatase [calcineurin] is *controlled* by in organisms ranging from yeast to mammals . Regulation PPP3CA RCAN1 20625401 2291760 Our data suggests that RCAN1 .4 expression is induced by VEGFR-2 activation in a Ca ( 2+ ) and PKC-delta dependent manner and that .4 acts to *regulate* [calcineurin] activity and gene expression facilitating endothelial cell migration and tubular morphogenesis . Regulation PPP3CA RCAN1 24155299 2859812 *controls* the activity of calcium/calmodulin dependent phosphatase [calcineurin (CaN)] , which has been implicated in human anxiety disorders . Regulation PPP3CB CAPN8 24987545 2948008 [Calcineurin] activity is *regulated* by , a cysteine protease present in the nucleus . Regulation PPP3CB CAPN8 24987545 2948092 Thus , we examined whether *regulates* [calcineurin] in renal tubule nuclei . Regulation PPP3CB PGC 21945104 2554965 Whether [calcineurin] can *control* expression has been proposed but is still controversial . Regulation PPP3CB RCAN1 12809556 1120695 Taking all these results into consideration we suggest that phosphorylation of is *involved* in the regulation of the phosphatase activity of [calcineurin] and can therefore act as a modulator of calcineurin dependent cellular pathways . Regulation PPP3CB RCAN1 17610901 1786686 Down syndrome candidate region 1-like 1 ( DSCR1-L1 ) mimics the inhibitory *effects* of on [calcineurin] signaling in endothelial cells and inhibits angiogenesis . Regulation PPP3CB RCAN1 18045910 1832895 ( RCAN1/MCIP1/DSCR1 ) *regulates* the calmodulin dependent phosphatase [calcineurin] . Regulation PPP3CB RCAN1 19136967 2032065 The calcium activated protein phosphatase [calcineurin] is *controlled* by in organisms ranging from yeast to mammals . Regulation PPP3CB RCAN1 24155299 2859813 *controls* the activity of calcium/calmodulin dependent phosphatase [calcineurin (CaN)] , which has been implicated in human anxiety disorders . Regulation PPP3CC CAPN8 24987545 2948022 [Calcineurin] activity is *regulated* by , a cysteine protease present in the nucleus . Regulation PPP3CC CAPN8 24987545 2948106 Thus , we examined whether *regulates* [calcineurin] in renal tubule nuclei . Regulation PPP3CC PGC 21945104 2554966 Whether [calcineurin] can *control* expression has been proposed but is still controversial . Regulation PPP3CC RCAN1 12809556 1120696 Taking all these results into consideration we suggest that phosphorylation of is *involved* in the regulation of the phosphatase activity of [calcineurin] and can therefore act as a modulator of calcineurin dependent cellular pathways . Regulation PPP3CC RCAN1 17610901 1786687 Down syndrome candidate region 1-like 1 ( DSCR1-L1 ) mimics the inhibitory *effects* of on [calcineurin] signaling in endothelial cells and inhibits angiogenesis . Regulation PPP3CC RCAN1 18045910 1832896 ( RCAN1/MCIP1/DSCR1 ) *regulates* the calmodulin dependent phosphatase [calcineurin] . Regulation PPP3CC RCAN1 19136967 2032068 The calcium activated protein phosphatase [calcineurin] is *controlled* by in organisms ranging from yeast to mammals . Regulation PPP3CC RCAN1 24155299 2859814 *controls* the activity of calcium/calmodulin dependent phosphatase [calcineurin (CaN)] , which has been implicated in human anxiety disorders . Regulation PPP3R1 CAPN8 14627704 1201076 This study established a molecular link between calpain and calcineurin , thereby demonstrating a new mechanism for proteolytical *regulation* of [calcineurin] by in response to certain pathological states . Regulation PPP3R1 CAPN8 17593948 1764768 Recent studies have demonstrated an interplay between calpain and calcineurin , in which can directly *regulate* [calcineurin] activity through proteolysis in glutamate stimulated neurons in culture and in vivo . Regulation PPP3R1 CAPN8 18445709 1938647 These data suggest that activation suppresses NMDAR function via proteolytic cleavage of NR2 subunits in vitro and in vivo , and the susceptibility of NMDARs to calpain cleavage is *controlled* by PSD-95 and [calcineurin] . Regulation PPP3R1 RCAN1 16649988 1557397 While can *regulate* [calcineurin] and GSK-3beta , it has also been shown that calcineurin and GSK-3beta can regulate RCAN1s . Regulation PPP3R1 RCAN1 20625401 2291762 Our data suggests that RCAN1 .4 expression is induced by VEGFR-2 activation in a Ca ( 2+ ) and PKC-delta dependent manner and that .4 acts to *regulate* [calcineurin] activity and gene expression facilitating endothelial cell migration and tubular morphogenesis . Regulation PPP3R1 TNF 8381656 212008 Taken together , these results indicate that the cytostatic *effect* of on T47D cells occurs at the G1/S transition of the cell cycle , and is mediated by an intracellular pathway which does not involve the activity of protein kinases C and A , nor protein phosphatases PP1 , [PP2B] . Regulation PPP5C TFPI2 11945080 930057 Subcellular localization of [PP5/TFPI-2] in human placenta : a possible *role* of as an anti-coagulant on the surface of syncytiotrophoblasts . Regulation PPT1 TFPI2 18922470 1977218 We show that Cdc37 and [PP5/Ppt1] associate in Hsp90 complexes in yeast and in human tumor cells , and that *regulates* phosphorylation of Ser13-Cdc37 in vivo , directly affecting activation of protein kinase clients by Hsp90-Cdc37 . Regulation PRDM1 STAT4 25073792 2953906 We report a crucial role for the transcriptional regulator [Blimp-1] , induced by IL-12 in a *dependent* manner , in controlling IL-10 expression in Th1 cells . Regulation PRDM1 TLR7 19157556 2048186 These results indicate that is a receptor for 8-SGuo and *plays* an essential role in the AID and [Blimp-1] expression ; Regulation PRDM16 PGC 23717545 2793044 The aim of the present study was to test the hypotheses that 1 ) a single exercise bout increases UCP1 mRNA in both inguinal ( i ) WAT and epididymal ( e ) WAT , 2 ) UCP1 expression and responsiveness to exercise are different in iWAT and eWAT , 3 ) PGC-1a determines the basal levels of UCP1 and PRDM16 in WAT and 4 ) exercise and exercise training regulate UCP1 and [PRDM16] expression in WAT in a *dependent* manner . Regulation PRDM2 TNF 20594067 2316022 [RIZ1] expression was induced in *response* to . Regulation PRDX1 IL1B 17890051 1843609 *Role* of and 5-HT2 receptors in midbrain [periaqueductal gray (PAG)] in potentiating defensive rage behavior in cat . Regulation PRDX6 EPHB2 21346153 2431603 These findings suggest that and p38 MAPK *regulate* subcellular localization of [Prdx6] by activation of 14-3-3e as a chaperone protein , resulting in its translocation to acidic organelles . Regulation PRDX6 TNF 16321424 1519019 We also investigated the *effects* of dexamethasone ( Dex ) , transforming growth factor-beta1 ( TGF-beta1 ) and ( TNF-alpha ) on [PRDX6] expression . Regulation PRDX6 TNF 16321424 1519021 Expression levels of PRDX6 mRNA in whole lenses isolated from postnatal day (PD) 1- to 18-month-old mice , and the *effects* of Dex , TGF-beta1 and on the expression of [PRDX6] in lens epithelial cells ( LECs ) , were monitored using real-time reverse transcriptase-polymerase chain reaction ( PCR ) or Western blot . Regulation PRG2 CTGF 15313168 1285344 The *regulation* of endothelial [proteoglycan] synthesis by is completely different from that by TGF-beta , suggesting that CTGF is not a downstream effector of TGF-beta but an independent regulator in vascular endothelial cells with respect to the proteoglycan synthesis . Regulation PRG2 CTGF 20819546 2318395 This study aimed to establish an in vitro cell culture model of rhesus monkey lumbar intervertebral discs and to investigate the *effect* of combined and tissue inhibitor of metalloprotease-1 ( TIMP-1 ) expression mediated by adeno associated virus ( AAV ) on collagen type II and [proteoglycan] levels . Regulation PRG2 IL1B 12465160 1022233 L-NMMA and CuDips completely corrected the suppressive *effect* of on [proteoglycan] synthesis , unlike with IL-17 . Regulation PRG2 IL1B 12954240 1137545 For both cell sub-populations , inhibited cell proliferation whereas [proteoglycan] synthesis was not *affected* . Regulation PRG2 IL1B 7551687 327202 This report describes the *effect* of and transforming growth factor-beta 1 ( TGF-beta 1 ) on [proteoglycan] release from cartilage explants and modification at the sulphation level . Regulation PRG2 IL1B 7997887 283224 The *effects* of and TGF-beta 1 on [proteoglycan] release and modifications in porcine articular cartilage explants are described . Regulation PRG2 IL1B 8118432 241910 Comparison of the *effects* of on [proteoglycan] synthesis by human skin and post-burn normal scar explant cultures . Regulation PRG2 IL1B 8373377 229727 *regulation* of fibroblast [proteoglycan] synthesis involves a decrease in versican steady-state mRNA levels . Regulation PRG2 IL1B 8503839 221191 Since previous studies have shown that PDGF enhances IL-1 alpha effects on metalloproteinase activity , in this report , we have examined whether PDGF modifies *effects* on cartilage [proteoglycan] synthesis . Regulation PRG2 TNF 7794042 313510 However , neutralising with a monoclonal antibody was effective in suppressing inflammatory changes in the joint during the acute onset of AIA , but it had little *effect* on the loss of [proteoglycan] from cartilage . Regulation PRG2 TNF 8536380 338525 CsA also reversed the inhibitory *effect* of PAF and on [proteoglycan] synthesis . Regulation PRG3 CTGF 15313168 1285345 The *regulation* of endothelial [proteoglycan] synthesis by is completely different from that by TGF-beta , suggesting that CTGF is not a downstream effector of TGF-beta but an independent regulator in vascular endothelial cells with respect to the proteoglycan synthesis . Regulation PRG3 CTGF 20819546 2318398 This study aimed to establish an in vitro cell culture model of rhesus monkey lumbar intervertebral discs and to investigate the *effect* of combined and tissue inhibitor of metalloprotease-1 ( TIMP-1 ) expression mediated by adeno associated virus ( AAV ) on collagen type II and [proteoglycan] levels . Regulation PRG3 IL1B 12465160 1022234 L-NMMA and CuDips completely corrected the suppressive *effect* of on [proteoglycan] synthesis , unlike with IL-17 . Regulation PRG3 IL1B 12954240 1137546 For both cell sub-populations , inhibited cell proliferation whereas [proteoglycan] synthesis was not *affected* . Regulation PRG3 IL1B 7551687 327204 This report describes the *effect* of and transforming growth factor-beta 1 ( TGF-beta 1 ) on [proteoglycan] release from cartilage explants and modification at the sulphation level . Regulation PRG3 IL1B 7997887 283226 The *effects* of and TGF-beta 1 on [proteoglycan] release and modifications in porcine articular cartilage explants are described . Regulation PRG3 IL1B 8118432 241911 Comparison of the *effects* of on [proteoglycan] synthesis by human skin and post-burn normal scar explant cultures . Regulation PRG3 IL1B 8373377 229728 *regulation* of fibroblast [proteoglycan] synthesis involves a decrease in versican steady-state mRNA levels . Regulation PRG3 IL1B 8503839 221192 Since previous studies have shown that PDGF enhances IL-1 alpha effects on metalloproteinase activity , in this report , we have examined whether PDGF modifies *effects* on cartilage [proteoglycan] synthesis . Regulation PRG3 TNF 7794042 313511 However , neutralising with a monoclonal antibody was effective in suppressing inflammatory changes in the joint during the acute onset of AIA , but it had little *effect* on the loss of [proteoglycan] from cartilage . Regulation PRG3 TNF 8536380 338531 CsA also reversed the inhibitory *effect* of PAF and on [proteoglycan] synthesis . Regulation PRG4 CTGF 15313168 1285346 The *regulation* of endothelial [proteoglycan] synthesis by is completely different from that by TGF-beta , suggesting that CTGF is not a downstream effector of TGF-beta but an independent regulator in vascular endothelial cells with respect to the proteoglycan synthesis . Regulation PRG4 CTGF 20819546 2318401 This study aimed to establish an in vitro cell culture model of rhesus monkey lumbar intervertebral discs and to investigate the *effect* of combined and tissue inhibitor of metalloprotease-1 ( TIMP-1 ) expression mediated by adeno associated virus ( AAV ) on collagen type II and [proteoglycan] levels . Regulation PRG4 IL1B 12465160 1022235 L-NMMA and CuDips completely corrected the suppressive *effect* of on [proteoglycan] synthesis , unlike with IL-17 . Regulation PRG4 IL1B 12954240 1137547 For both cell sub-populations , inhibited cell proliferation whereas [proteoglycan] synthesis was not *affected* . Regulation PRG4 IL1B 7551687 327206 This report describes the *effect* of and transforming growth factor-beta 1 ( TGF-beta 1 ) on [proteoglycan] release from cartilage explants and modification at the sulphation level . Regulation PRG4 IL1B 7997887 283228 The *effects* of and TGF-beta 1 on [proteoglycan] release and modifications in porcine articular cartilage explants are described . Regulation PRG4 IL1B 8118432 241912 Comparison of the *effects* of on [proteoglycan] synthesis by human skin and post-burn normal scar explant cultures . Regulation PRG4 IL1B 8373377 229729 *regulation* of fibroblast [proteoglycan] synthesis involves a decrease in versican steady-state mRNA levels . Regulation PRG4 IL1B 8503839 221193 Since previous studies have shown that PDGF enhances IL-1 alpha effects on metalloproteinase activity , in this report , we have examined whether PDGF modifies *effects* on cartilage [proteoglycan] synthesis . Regulation PRG4 TNF 22776731 2627749 This study was designed to evaluate the combined *effects* of intermittent hydrostatic pressure ( IHP ) and TGF-ß1 or on [proteoglycan4 (PRG4)] expression in rat temporomandibular synovial fibroblasts ( SFs ) . Regulation PRG4 TNF 7794042 313512 However , neutralising with a monoclonal antibody was effective in suppressing inflammatory changes in the joint during the acute onset of AIA , but it had little *effect* on the loss of [proteoglycan] from cartilage . Regulation PRG4 TNF 8536380 338537 CsA also reversed the inhibitory *effect* of PAF and on [proteoglycan] synthesis . Regulation PRKAA1 AXIN2 24093678 2852025 Importantly , adenovirus based knockdown of AXIN in the mouse liver impaired AMPK activation and caused exacerbated fatty liver after starvation , underscoring an essential *role* of in [AMPK] activation . Regulation PRKAA1 C1QTNF1 22086915 2534471 Consistent with the direct *effect* of on [AMPK] signaling , recombinant CTRP1 administration acutely stimulated muscle AMPKa and ACC phosphorylation in vivo . Regulation PRKAA1 SPHK1 21163859 2407761 In contrast , deficiency did not *affect* [AMPK] activation . Regulation PRKAA1 TNF 17141630 1653671 Importantly even at pathologically elevated levels of TNFalpha observed in obesity , the suppressive *effects* of on [AMPK] signaling are reversed in mice null for both TNFR1 and 2 or following treatment with a TNFalpha neutralizing antibody . Regulation PRKAA1 TNF 21352507 2426451 In conclusion , IL-6 affects exercise induced glycogen use , [AMPK] signalling and mRNA *responses* in mouse skeletal muscle . Regulation PRKAA2 AXIN2 24093678 2852027 Importantly , adenovirus based knockdown of AXIN in the mouse liver impaired AMPK activation and caused exacerbated fatty liver after starvation , underscoring an essential *role* of in [AMPK] activation . Regulation PRKAA2 C1QTNF1 22086915 2534472 Consistent with the direct *effect* of on [AMPK] signaling , recombinant CTRP1 administration acutely stimulated muscle AMPKa and ACC phosphorylation in vivo . Regulation PRKAA2 SPHK1 21163859 2407762 In contrast , deficiency did not *affect* [AMPK] activation . Regulation PRKAA2 TNF 17141630 1653672 Importantly even at pathologically elevated levels of TNFalpha observed in obesity , the suppressive *effects* of on [AMPK] signaling are reversed in mice null for both TNFR1 and 2 or following treatment with a TNFalpha neutralizing antibody . Regulation PRKAA2 TNF 21352507 2426453 In conclusion , IL-6 affects exercise induced glycogen use , [AMPK] signalling and mRNA *responses* in mouse skeletal muscle . Regulation PRKAB1 AXIN2 24093678 2852029 Importantly , adenovirus based knockdown of AXIN in the mouse liver impaired AMPK activation and caused exacerbated fatty liver after starvation , underscoring an essential *role* of in [AMPK] activation . Regulation PRKAB1 C1QTNF1 22086915 2534473 Consistent with the direct *effect* of on [AMPK] signaling , recombinant CTRP1 administration acutely stimulated muscle AMPKa and ACC phosphorylation in vivo . Regulation PRKAB1 SPHK1 21163859 2407763 In contrast , deficiency did not *affect* [AMPK] activation . Regulation PRKAB1 TNF 17141630 1653673 Importantly even at pathologically elevated levels of TNFalpha observed in obesity , the suppressive *effects* of on [AMPK] signaling are reversed in mice null for both TNFR1 and 2 or following treatment with a TNFalpha neutralizing antibody . Regulation PRKAB1 TNF 21352507 2426455 In conclusion , IL-6 affects exercise induced glycogen use , [AMPK] signalling and mRNA *responses* in mouse skeletal muscle . Regulation PRKAB2 AXIN2 24093678 2852031 Importantly , adenovirus based knockdown of AXIN in the mouse liver impaired AMPK activation and caused exacerbated fatty liver after starvation , underscoring an essential *role* of in [AMPK] activation . Regulation PRKAB2 C1QTNF1 22086915 2534474 Consistent with the direct *effect* of on [AMPK] signaling , recombinant CTRP1 administration acutely stimulated muscle AMPKa and ACC phosphorylation in vivo . Regulation PRKAB2 SPHK1 21163859 2407764 In contrast , deficiency did not *affect* [AMPK] activation . Regulation PRKAB2 TNF 17141630 1653674 Importantly even at pathologically elevated levels of TNFalpha observed in obesity , the suppressive *effects* of on [AMPK] signaling are reversed in mice null for both TNFR1 and 2 or following treatment with a TNFalpha neutralizing antibody . Regulation PRKAB2 TNF 21352507 2426457 In conclusion , IL-6 affects exercise induced glycogen use , [AMPK] signalling and mRNA *responses* in mouse skeletal muscle . Regulation PRKACB CAPN8 19642365 2113319 The event was suppressed by pre-treatment with various calpain inhibitors , indicating that [PKA] inhibitor mediated shedding was *dependent* . Regulation PRKACB CAPN8 23410952 2793933 In the process of validating this assay , we discovered that [PKA] activity is *regulated* by the protease . Regulation PRKACB CAPN8 8630329 361165 In this study , we investigated the *effect* of activation on [PKA] and its phosphorylation activity in stimulated type II cells . Regulation PRKACB EPHB2 16926362 1603357 [PKA] activity is also *regulated* by the interaction of other proteins with the regulatory ( R ) or catalytic ( C ) subunits of PKA , and a mechanism has been uncovered in which ribosomal S6 kinase ( RSK1 ) interacts with either PKA subunit , depending on whether RSK1 has been phosphorylated and activated by extracellular signal regulated kinase ( ) . Regulation PRKACB GPR115 15499021 1326281 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Regulation PRKACB GPR132 15499021 1326270 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Regulation PRKACB GPR87 15499021 1326350 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Regulation PRKACB HSD11B2 16872738 1600687 In the present study we show that expression in human renal epithelial P58 cells is regulated at the mRNA and protein level , and that [protein kinases A (PKA)] and C ( PKC ) are *involved* in this process . Regulation PRKACB TNF 2549168 117431 As in these typical TNF producer cells , the production of is also *controlled* by [PKA] and PKC , a regulatory circuit is proposed , by which these two independent signal pathways antagonistically regulate TNF production and , at the receptor level , TNF sensitivity . Regulation PRKACG CAPN8 19642365 2113333 The event was suppressed by pre-treatment with various calpain inhibitors , indicating that [PKA] inhibitor mediated shedding was *dependent* . Regulation PRKACG CAPN8 23410952 2793947 In the process of validating this assay , we discovered that [PKA] activity is *regulated* by the protease . Regulation PRKACG CAPN8 8630329 361179 In this study , we investigated the *effect* of activation on [PKA] and its phosphorylation activity in stimulated type II cells . Regulation PRKACG EPHB2 16926362 1603358 [PKA] activity is also *regulated* by the interaction of other proteins with the regulatory ( R ) or catalytic ( C ) subunits of PKA , and a mechanism has been uncovered in which ribosomal S6 kinase ( RSK1 ) interacts with either PKA subunit , depending on whether RSK1 has been phosphorylated and activated by extracellular signal regulated kinase ( ) . Regulation PRKACG GPR115 15499021 1326374 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Regulation PRKACG GPR132 15499021 1326363 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Regulation PRKACG GPR87 15499021 1326443 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Regulation PRKACG HSD11B2 16872738 1600688 In the present study we show that expression in human renal epithelial P58 cells is regulated at the mRNA and protein level , and that [protein kinases A (PKA)] and C ( PKC ) are *involved* in this process . Regulation PRKACG TNF 2549168 117432 As in these typical TNF producer cells , the production of is also *controlled* by [PKA] and PKC , a regulatory circuit is proposed , by which these two independent signal pathways antagonistically regulate TNF production and , at the receptor level , TNF sensitivity . Regulation PRKAG1 AXIN2 24093678 2852033 Importantly , adenovirus based knockdown of AXIN in the mouse liver impaired AMPK activation and caused exacerbated fatty liver after starvation , underscoring an essential *role* of in [AMPK] activation . Regulation PRKAG1 C1QTNF1 22086915 2534475 Consistent with the direct *effect* of on [AMPK] signaling , recombinant CTRP1 administration acutely stimulated muscle AMPKa and ACC phosphorylation in vivo . Regulation PRKAG1 SPHK1 21163859 2407765 In contrast , deficiency did not *affect* [AMPK] activation . Regulation PRKAG1 TNF 17141630 1653675 Importantly even at pathologically elevated levels of TNFalpha observed in obesity , the suppressive *effects* of on [AMPK] signaling are reversed in mice null for both TNFR1 and 2 or following treatment with a TNFalpha neutralizing antibody . Regulation PRKAG1 TNF 21352507 2426459 In conclusion , IL-6 affects exercise induced glycogen use , [AMPK] signalling and mRNA *responses* in mouse skeletal muscle . Regulation PRKAG2 AXIN2 24093678 2852035 Importantly , adenovirus based knockdown of AXIN in the mouse liver impaired AMPK activation and caused exacerbated fatty liver after starvation , underscoring an essential *role* of in [AMPK] activation . Regulation PRKAG2 C1QTNF1 22086915 2534476 Consistent with the direct *effect* of on [AMPK] signaling , recombinant CTRP1 administration acutely stimulated muscle AMPKa and ACC phosphorylation in vivo . Regulation PRKAG2 SPHK1 21163859 2407766 In contrast , deficiency did not *affect* [AMPK] activation . Regulation PRKAG2 TNF 17141630 1653676 Importantly even at pathologically elevated levels of TNFalpha observed in obesity , the suppressive *effects* of on [AMPK] signaling are reversed in mice null for both TNFR1 and 2 or following treatment with a TNFalpha neutralizing antibody . Regulation PRKAG2 TNF 21352507 2426461 In conclusion , IL-6 affects exercise induced glycogen use , [AMPK] signalling and mRNA *responses* in mouse skeletal muscle . Regulation PRKAR1A CAPN8 19642365 2113347 The event was suppressed by pre-treatment with various calpain inhibitors , indicating that [PKA] inhibitor mediated shedding was *dependent* . Regulation PRKAR1A CAPN8 23410952 2793961 In the process of validating this assay , we discovered that [PKA] activity is *regulated* by the protease . Regulation PRKAR1A CAPN8 8630329 361193 In this study , we investigated the *effect* of activation on [PKA] and its phosphorylation activity in stimulated type II cells . Regulation PRKAR1A EPHB2 16926362 1603359 [PKA] activity is also *regulated* by the interaction of other proteins with the regulatory ( R ) or catalytic ( C ) subunits of PKA , and a mechanism has been uncovered in which ribosomal S6 kinase ( RSK1 ) interacts with either PKA subunit , depending on whether RSK1 has been phosphorylated and activated by extracellular signal regulated kinase ( ) . Regulation PRKAR1A GPR115 15499021 1326467 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Regulation PRKAR1A GPR132 15499021 1326456 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Regulation PRKAR1A GPR87 15499021 1326536 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Regulation PRKAR1A HSD11B2 16872738 1600689 In the present study we show that expression in human renal epithelial P58 cells is regulated at the mRNA and protein level , and that [protein kinases A (PKA)] and C ( PKC ) are *involved* in this process . Regulation PRKAR1A TNF 2549168 117433 As in these typical TNF producer cells , the production of is also *controlled* by [PKA] and PKC , a regulatory circuit is proposed , by which these two independent signal pathways antagonistically regulate TNF production and , at the receptor level , TNF sensitivity . Regulation PRKAR1B CAPN8 19642365 2113361 The event was suppressed by pre-treatment with various calpain inhibitors , indicating that [PKA] inhibitor mediated shedding was *dependent* . Regulation PRKAR1B CAPN8 23410952 2793975 In the process of validating this assay , we discovered that [PKA] activity is *regulated* by the protease . Regulation PRKAR1B CAPN8 8630329 361207 In this study , we investigated the *effect* of activation on [PKA] and its phosphorylation activity in stimulated type II cells . Regulation PRKAR1B EPHB2 16926362 1603360 [PKA] activity is also *regulated* by the interaction of other proteins with the regulatory ( R ) or catalytic ( C ) subunits of PKA , and a mechanism has been uncovered in which ribosomal S6 kinase ( RSK1 ) interacts with either PKA subunit , depending on whether RSK1 has been phosphorylated and activated by extracellular signal regulated kinase ( ) . Regulation PRKAR1B GPR115 15499021 1326560 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Regulation PRKAR1B GPR132 15499021 1326549 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Regulation PRKAR1B GPR87 15499021 1326629 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Regulation PRKAR1B HSD11B2 16872738 1600690 In the present study we show that expression in human renal epithelial P58 cells is regulated at the mRNA and protein level , and that [protein kinases A (PKA)] and C ( PKC ) are *involved* in this process . Regulation PRKAR1B TNF 2549168 117434 As in these typical TNF producer cells , the production of is also *controlled* by [PKA] and PKC , a regulatory circuit is proposed , by which these two independent signal pathways antagonistically regulate TNF production and , at the receptor level , TNF sensitivity . Regulation PRKAR2A CAPN8 19642365 2113375 The event was suppressed by pre-treatment with various calpain inhibitors , indicating that [PKA] inhibitor mediated shedding was *dependent* . Regulation PRKAR2A CAPN8 23410952 2793989 In the process of validating this assay , we discovered that [PKA] activity is *regulated* by the protease . Regulation PRKAR2A CAPN8 8630329 361221 In this study , we investigated the *effect* of activation on [PKA] and its phosphorylation activity in stimulated type II cells . Regulation PRKAR2A EPHB2 16926362 1603361 [PKA] activity is also *regulated* by the interaction of other proteins with the regulatory ( R ) or catalytic ( C ) subunits of PKA , and a mechanism has been uncovered in which ribosomal S6 kinase ( RSK1 ) interacts with either PKA subunit , depending on whether RSK1 has been phosphorylated and activated by extracellular signal regulated kinase ( ) . Regulation PRKAR2A GPR115 15499021 1326653 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Regulation PRKAR2A GPR132 15499021 1326642 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Regulation PRKAR2A GPR87 15499021 1326722 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Regulation PRKAR2A HSD11B2 16872738 1600691 In the present study we show that expression in human renal epithelial P58 cells is regulated at the mRNA and protein level , and that [protein kinases A (PKA)] and C ( PKC ) are *involved* in this process . Regulation PRKAR2A TNF 2549168 117435 As in these typical TNF producer cells , the production of is also *controlled* by [PKA] and PKC , a regulatory circuit is proposed , by which these two independent signal pathways antagonistically regulate TNF production and , at the receptor level , TNF sensitivity . Regulation PRKAR2B CAPN8 19642365 2113389 The event was suppressed by pre-treatment with various calpain inhibitors , indicating that [PKA] inhibitor mediated shedding was *dependent* . Regulation PRKAR2B CAPN8 23410952 2794003 In the process of validating this assay , we discovered that [PKA] activity is *regulated* by the protease . Regulation PRKAR2B CAPN8 8630329 361235 In this study , we investigated the *effect* of activation on [PKA] and its phosphorylation activity in stimulated type II cells . Regulation PRKAR2B EPHB2 16926362 1603362 [PKA] activity is also *regulated* by the interaction of other proteins with the regulatory ( R ) or catalytic ( C ) subunits of PKA , and a mechanism has been uncovered in which ribosomal S6 kinase ( RSK1 ) interacts with either PKA subunit , depending on whether RSK1 has been phosphorylated and activated by extracellular signal regulated kinase ( ) . Regulation PRKAR2B GPR115 15499021 1326746 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Regulation PRKAR2B GPR132 15499021 1326735 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Regulation PRKAR2B GPR87 15499021 1326815 *dependent* activation of [protein kinase A (PKA)] led to phosphorylation of RCS at Ser55 and increased its binding to CaM . Regulation PRKAR2B HSD11B2 16872738 1600692 In the present study we show that expression in human renal epithelial P58 cells is regulated at the mRNA and protein level , and that [protein kinases A (PKA)] and C ( PKC ) are *involved* in this process . Regulation PRKAR2B TNF 2549168 117436 As in these typical TNF producer cells , the production of is also *controlled* by [PKA] and PKC , a regulatory circuit is proposed , by which these two independent signal pathways antagonistically regulate TNF production and , at the receptor level , TNF sensitivity . Regulation PRKCA EPHB2 12048219 968715 Inhibition of [PKCalpha] activity was *independent* of NO-induced activation of or p38 kinase and occurred due to blockage of expression . Regulation PRKCA EPHB2 12676358 1076766 *dependent* activation of only [PKCalpha] was observed in immunoprecipitates obtained from 5-HT(1A) agonist treated HN2-5 cells . Regulation PRKCA MAP2K6 9645686 514774 Insulin induction of [protein kinase C alpha] expression is independent of insulin receptor Tyr1162/1163 residues and *involves* 1 and sustained activation of nuclear p44MAPK . Regulation PRKCA TNF 10887171 730512 Fumonisin B ( 1 ) , an inhibitor of ceramide synthase , and glutathione , an inhibitor of neutral sphingomyelinase , both reversed the *effect* of on [PKC alpha] activity , suggesting that ceramide production is necessary for the action of TNF-alpha . Regulation PRKCA TNF 10887171 730513 Okadaic acid at 2 nm , a potent protein phosphatase inhibitor , blocked the *effects* of on [PKC alpha] activity , but not on PKC alpha translocation , thus demonstrating that dephosphorylation and translocation are independent processes . Regulation PRKCB ANGPT1 14584044 1187138 Opposing *effect* of on VEGF mediated disruption of endothelial cell-cell interactions requires activation of [PKC beta] . Regulation PRKD1 GPR115 11410587 849673 Rapid [protein kinase D] translocation in *response* to activation . Regulation PRKD1 GPR132 11410587 849662 Rapid [protein kinase D] translocation in *response* to activation . Regulation PRKD1 GPR87 11410587 849742 Rapid [protein kinase D] translocation in *response* to activation . Regulation PRL EDN2 11887934 894222 In this study , we examined how the ovarian steroid background determines the efficiency of the mediated autocrine feedback *regulation* of [PRL] secretion . Regulation PRL EDN2 12668868 1075891 We have previously found that the ovarian steroid background determines the efficiency of the mediated autocrine feedback *regulation* of [prolactin (PRL)] secretion . Regulation PRL EPHB2 21285319 2403442 The gsp oncogene disrupts dependent [prolactin] gene *regulation* in gsp inducible somatotroph cell line . Regulation PRL IL1B 12697678 1081347 We have therefore examined the effects of AGRP on the HPA axis and on [prolactin (PRL)] at baseline and in *response* to stimulation by in nine ovariectomized rhesus monkeys . Regulation PRL IL1B 1802676 177003 The *effects* of human recombinant and -6 and tumor necrosis factor-alpha (TNF-alpha) on the releases of [PRL] and dopamine were examined using monolayer cultures of rat pituitary cells and hypothalamic cells . Regulation PRL IL1B 2556147 122088 The *effect* of on [prolactin] secretion and on phosphoinositide turnover in anterior pituitary cells was evaluated . Regulation PRL IL1B 9623597 511016 The effect of IL-1beta on amniotic fluid [prolactin] does not appear to be mediated by PGs and may *involve* a direct effect of on decidual cells . Regulation PRL SYNM 1028949 4947 They further suggest that the may *play* role in the control of [PRL] release . Regulation PRL TGM2 6138286 31208 *Effects* of or phospholipase A2 inhibitors on down-regulation of [prolactin] receptors and stimulation of casein and DNA synthesis in mammary gland explants . Regulation PRL TNF 10963045 727274 These results indicate that *plays* an inhibitory role in anterior pituitary cell growth and the release of [PRL] in an estrogen dependent manner . Regulation PRL TNF 11474215 841759 Nitric oxide mediates the inhibitory *effect* of on [prolactin] release . Regulation PRL TNF 12207161 983476 This increase in dopaminergic activity could mediate the inhibitory *effect* of LPS and on [prolactin] release . Regulation PRL TNF 16254029 1508477 Similar *regulation* of the endogenous rat [prolactin] gene by in GH3 cells was confirmed using real-time PCR . Regulation PRL TNF 17336385 1726618 Similarly , there is no autocrine or paracrine *effect* of on GH or [PRL] induced NO production and iNOS expression . Regulation PRL TNF 1802676 177001 *Effect* of on [prolactin] secretion from rat anterior pituitary and dopamine release from the hypothalamus : comparison with the effect of interleukin-1 beta . Regulation PRL TNF 1802676 177002 The *effects* of human recombinant interleukin-1 beta and -6 and on the releases of [PRL] and dopamine were examined using monolayer cultures of rat pituitary cells and hypothalamic cells . Regulation PRL TNF 7479297 331851 We examined the chronic ( 72 h ) *effects* of 30 ng/ml recombinant murine on release of immunoreactive growth hormone (GH) , [prolactin (PRL)] , thyrotropin ( TSH ) , and TSH glycosylation , as assessed by lectin binding , in cultured rat anterior pituitary cells . Regulation PRL TNF 9741828 532165 We also investigated the *effect* of on [prolactin] release . Regulation PRNP TNF 22116041 2541356 However , as it is known that Cbl deficiency damages myelin by increasing and decreasing epidermal growth factor (EGF) levels in rat spinal cord ( SC ) , and that TNF-a and EGF *regulate* [PrP] ( C ) expression in vitro , we investigated whether Cbl deficiency modifies SC PrP ( C ) and PrP ( C ) -mRNA levels in Cbl-D rats . Regulation PRNP TNF 8790403 380922 To clarify the *role* of in experimental [CJD] , we investigated the expression of TNF-alpha in brain tissues from CJD virus infected mice at weekly intervals after inoculation by reverse transcription coupled PCR , Northern and Western blot analyses , and immunocytochemical staining . Regulation PRNT TNF 12957651 1137910 *Regulation* of intrinsic [prion protein] by growth factors and : the role of intracellular reactive oxygen species . Regulation PROC F2R 8391599 224367 One of the mechanisms by which prevention is achieved *involves* a cell surface , thrombomodulin , which converts thrombin from a procoagulant into an anticoagulant due to accelerating thrombin catalyzed activation of an anticoagulant protease zymogen , protein C . [Activated protein C] then proteolytically inactivates coagulation cofactors , Factors Va and VIIIa , in concert with another anticoagulant protein S . Activated protein C is finally neutralized by protein C inhibitor . Regulation PROCR TNF 15733976 1378043 The objective of this study was to elucidate the *effects* of on the expression of thrombomodulin (TM) and [endothelial protein C receptor (EPCR)] in human endothelial cells as well as the effect of curcumin , a spice and coloring food compound , as a potential therapeutic agent . Regulation PRODH MYLIP 23764530 2828425 Based on expression and functional analysis , we identified miR172 , miR396a , miR396c and miR4233 may regulate P5CS gene , and and miR6461 may *regulate* P5CR and [ProDH] gene , respectively . Regulation PRODH PPP3CA 15914462 1440317 The activation of *regulated* transcription factor pathways by [proline oxidase] might affect gene expression events important to p53 regulation of cell growth and apoptosis . Regulation PRODH PPP3R1 15914462 1440318 The activation of *regulated* transcription factor pathways by [proline oxidase] might affect gene expression events important to p53 regulation of cell growth and apoptosis . Regulation PRODH TP53 23861960 2817422 Here , we confirmed *dependent* induction of endogenous [PRODH] in response to genotoxic damage in cell lines of different histological origin . Regulation PROM1 GPR87 23593389 2773479 In this study , we explored the *role* of in the regulation of [CD133] expression . Regulation PROM1 ID1 24572994 2924801 and NF-?B *regulate* the expression of [CD133] and BMI-1 in an additive or synergistic manner in OSCC , which is associated with the generation of naïve and self-renewable keratinocytes and initiate the growth of xenograft tumors in vivo . Regulation PROM1 MMP7 18276951 1872085 Thus , MMP-7 is expressed in fetal membranes ( amnion , chorion , and decidua ) , and its activity is increased in amnion of PROM at term , accompanied with the reduced level of TIMP-1 , which may suggest the possible *involvement* of in [PROM] . Regulation PROM2 MMP7 18276951 1872084 Thus , MMP-7 is expressed in fetal membranes ( amnion , chorion , and decidua ) , and its activity is increased in amnion of PROM at term , accompanied with the reduced level of TIMP-1 , which may suggest the possible *involvement* of in [PROM] . Regulation PRS EDN2 23469133 2750249 To examine directly the *role* of in mutant [PRs] , we used a scAAV5-Edn2 cDNA vector to restore Edn2 expression in Pde6b ( rd1/rd1 ) ; Regulation PRSS21 CALCA 2761409 116498 Recent studies demonstrating decreases in transport kinetics of zinc ( Zn ) in [testis in] *response* to and the presence of CT receptors on Leydig cells has suggested a physiological interrelationship between CT and cellular Zn metabolism in the testis . Regulation PRSS21 EGR1 20947496 2353715 Compared with wild-type controls , GPRC6A ( -/- ) null mice exhibit significantly less ERK activation and expression in both bone marrow and [testis in] *response* to pharmacological doses of testosterone in vivo . Regulation PRSS21 EPHB2 20947496 2353716 Compared with wild-type controls , GPRC6A ( -/- ) null mice exhibit significantly less activation and Egr-1 expression in both bone marrow and [testis in] *response* to pharmacological doses of testosterone in vivo . Regulation PRSS21 HCG11 7299325 17942 The timing of these changes suggests that HCG does not affect the capillaries directly , but it would seem that the changes are due to some substances secreted by the [testis in] *response* to the . Regulation PRSS21 HCG14 7299325 17943 The timing of these changes suggests that HCG does not affect the capillaries directly , but it would seem that the changes are due to some substances secreted by the [testis in] *response* to the . Regulation PRSS21 HCG15 7299325 17944 The timing of these changes suggests that HCG does not affect the capillaries directly , but it would seem that the changes are due to some substances secreted by the [testis in] *response* to the . Regulation PRSS21 HCG16 7299325 17947 The timing of these changes suggests that HCG does not affect the capillaries directly , but it would seem that the changes are due to some substances secreted by the [testis in] *response* to the . Regulation PRSS21 HCG17 7299325 17958 The timing of these changes suggests that HCG does not affect the capillaries directly , but it would seem that the changes are due to some substances secreted by the [testis in] *response* to the . Regulation PRSS21 HCG18 7299325 17957 The timing of these changes suggests that HCG does not affect the capillaries directly , but it would seem that the changes are due to some substances secreted by the [testis in] *response* to the . Regulation PRSS21 HCG20 7299325 17955 The timing of these changes suggests that HCG does not affect the capillaries directly , but it would seem that the changes are due to some substances secreted by the [testis in] *response* to the . Regulation PRSS21 HCG21 7299325 17956 The timing of these changes suggests that HCG does not affect the capillaries directly , but it would seem that the changes are due to some substances secreted by the [testis in] *response* to the . Regulation PRSS21 HCG22 7299325 17953 The timing of these changes suggests that HCG does not affect the capillaries directly , but it would seem that the changes are due to some substances secreted by the [testis in] *response* to the . Regulation PRSS21 HCG23 7299325 17945 The timing of these changes suggests that HCG does not affect the capillaries directly , but it would seem that the changes are due to some substances secreted by the [testis in] *response* to the . Regulation PRSS21 HCG24 7299325 17951 The timing of these changes suggests that HCG does not affect the capillaries directly , but it would seem that the changes are due to some substances secreted by the [testis in] *response* to the . Regulation PRSS21 HCG25 7299325 17946 The timing of these changes suggests that HCG does not affect the capillaries directly , but it would seem that the changes are due to some substances secreted by the [testis in] *response* to the . Regulation PRSS21 HCG26 7299325 17954 The timing of these changes suggests that HCG does not affect the capillaries directly , but it would seem that the changes are due to some substances secreted by the [testis in] *response* to the . Regulation PRSS21 HCG27 7299325 17952 The timing of these changes suggests that HCG does not affect the capillaries directly , but it would seem that the changes are due to some substances secreted by the [testis in] *response* to the . Regulation PRSS21 HCG4 7299325 17948 The timing of these changes suggests that HCG does not affect the capillaries directly , but it would seem that the changes are due to some substances secreted by the [testis in] *response* to the . Regulation PRSS21 HCG8 7299325 17949 The timing of these changes suggests that HCG does not affect the capillaries directly , but it would seem that the changes are due to some substances secreted by the [testis in] *response* to the . Regulation PRSS21 HCG9 7299325 17950 The timing of these changes suggests that HCG does not affect the capillaries directly , but it would seem that the changes are due to some substances secreted by the [testis in] *response* to the . Regulation PRSS21 SRC 10698670 671904 We evaluated the *role* of tyrosine kinase in control and EGME treated adult rat [testis in] vivo , as well as in vitro using cultured adult rat seminiferous tubules treated with MAA . Regulation PRTN3 TNF 16997860 1647248 In the literature , the requirement of TNF priming has been attributed to an *effect* of on the expression of [PR3] or MPO on the cell surface . Regulation PSEN1 EFNB1 16511561 1535652 These data show that the [PS1/gamma-secretase] system *controls* Src activation and phosphorylation by regulating production of Src activator ephrinB2/CTF2 . Regulation PSEN1 ID1 19920078 2171793 [PS1] can *control* , which affects satellite cell fate by regulating the transcriptional activity of MyoD . Regulation PSENEN ALOX5 17998412 1882722 These data establish for the first time a novel functional role for <5LO> in the pathogenesis of AD-like amyloidosis , thereby *modulating* [gamma-secretase] activity . Regulation PSENEN EFNB1 16511561 1535648 These data show that the [PS1/gamma-secretase] system *controls* Src activation and phosphorylation by regulating production of Src activator ephrinB2/CTF2 . Regulation PSIP1 IL1B 1334680 205898 Neither IL-1 alpha nor *affected* the [PIC] activity of membrane or cytosolic fractions . Regulation PSIP1 ITGB2 10858245 704670 In this study , we investigated whether deficiency in cattle *affects* [proinflammatory cytokine (PIC)] expression in pulmonary tissue after respiratory infection with Pasteurella haemolytica . Regulation PSMA1 TNF 16566573 1542233 *Effects* of on the [26S proteasome] and 19S regulator in skeletal muscle of severely scalded mice . Regulation PSMA2 TNF 16566573 1542234 *Effects* of on the [26S proteasome] and 19S regulator in skeletal muscle of severely scalded mice . Regulation PSMA3 TNF 16566573 1542235 *Effects* of on the [26S proteasome] and 19S regulator in skeletal muscle of severely scalded mice . Regulation PSMA4 TNF 16566573 1542236 *Effects* of on the [26S proteasome] and 19S regulator in skeletal muscle of severely scalded mice . Regulation PSMA5 TNF 16566573 1542237 *Effects* of on the [26S proteasome] and 19S regulator in skeletal muscle of severely scalded mice . Regulation PSMA6 TNF 16566573 1542238 *Effects* of on the [26S proteasome] and 19S regulator in skeletal muscle of severely scalded mice . Regulation PSMA7 TNF 16566573 1542239 *Effects* of on the [26S proteasome] and 19S regulator in skeletal muscle of severely scalded mice . Regulation PSMB1 TNF 16566573 1542240 *Effects* of on the [26S proteasome] and 19S regulator in skeletal muscle of severely scalded mice . Regulation PSMB2 TNF 16566573 1542241 *Effects* of on the [26S proteasome] and 19S regulator in skeletal muscle of severely scalded mice . Regulation PSMB3 TNF 16566573 1542242 *Effects* of on the [26S proteasome] and 19S regulator in skeletal muscle of severely scalded mice . Regulation PSMB4 TNF 16566573 1542243 *Effects* of on the [26S proteasome] and 19S regulator in skeletal muscle of severely scalded mice . Regulation PSMB5 TNF 16566573 1542244 *Effects* of on the [26S proteasome] and 19S regulator in skeletal muscle of severely scalded mice . Regulation PSMB6 TNF 16566573 1542245 *Effects* of on the [26S proteasome] and 19S regulator in skeletal muscle of severely scalded mice . Regulation PSMB7 TNF 16566573 1542246 *Effects* of on the [26S proteasome] and 19S regulator in skeletal muscle of severely scalded mice . Regulation PSMB9 TNF 15240699 1270384 These results show that LPS and *regulate* the induction of Tap1 and [Lmp2] through STAT1 , but use distinct areas of the promoter . Regulation PSMB9 TNF 20223233 2254380 SAMe prevented the increase in the TNFalpha and IFNgamma receptors , supporting the idea that and IFNgamma were *responsible* for the up regulation of [LMP2] , LPM7 , and FAT10 . Regulation PSMC1 TNF 16566573 1542247 *Effects* of on the [26S proteasome] and 19S regulator in skeletal muscle of severely scalded mice . Regulation PSMC2 TNF 16566573 1542248 *Effects* of on the [26S proteasome] and 19S regulator in skeletal muscle of severely scalded mice . Regulation PSMC3 TNF 16566573 1542249 *Effects* of on the [26S proteasome] and 19S regulator in skeletal muscle of severely scalded mice . Regulation PSMC4 TNF 16566573 1542250 *Effects* of on the [26S proteasome] and 19S regulator in skeletal muscle of severely scalded mice . Regulation PSMC5 TNF 16566573 1542251 *Effects* of on the [26S proteasome] and 19S regulator in skeletal muscle of severely scalded mice . Regulation PSMC6 TNF 16566573 1542252 *Effects* of on the [26S proteasome] and 19S regulator in skeletal muscle of severely scalded mice . Regulation PSMD13 TNF 16566573 1542253 *Effects* of on the [26S proteasome] and 19S regulator in skeletal muscle of severely scalded mice . Regulation PSMD4 TNF 16566573 1542254 *Effects* of on the [26S proteasome] and 19S regulator in skeletal muscle of severely scalded mice . Regulation PTBP1 CCL17 22057112 2540302 The direct *effects* of on [DCs] and the indirect effects on differentiation of T helper ( Th ) cells were determined in vitro and ex vivo . Regulation PTBP1 CD14 9680340 521006 Cultures enriched in *dependent* [DCs] were more potent stimulators of a mixed leukocyte reaction , compared with control GTS cultures containing both types of DCs . Regulation PTBP1 CD14 9680340 521018 Although TNF is required to ensure the institution of DC hematopoiesis from CD34 ( + ) progenitor cells , its activity on a later progenitor appears to limit the development of *dependent* [DCs] . Regulation PTBP1 FAS 21297009 2420023 The decrease in the numbers of CD8 ( + ) [DCs] required iNKT cells but was *independent* of perforin , , or IFN-? , as it was observed in mice deficient in each of these molecules . Regulation PTBP1 ITGAL 20530790 2315696 Although LFA-1 ( lymphocyte function associated antigen 1 ) on T cells is considered to be important for antigen-specific T-cell activation , the *role* for on [DCs] remains elusive . Regulation PTBP1 ITGB2 19234188 2040169 Taken together , one of the mechanisms of Treg mediated suppression functions across species and mediates an *dependent* interaction between Tregs and [DCs] . Regulation PTBP1 ITGB2 23817428 2815802 Therefore , our results indicate that *dependent* interactions between T cells and [DCs] play a crucial role not only in supporting firm arrest during Ag recognition but also in facilitating the Ag scanning processes . Regulation PTBP1 MUC16 15944279 1416093 We have investigated whether a released by tumor cells could be *involved* in causing these immunomodulating effects on [DCs] . Regulation PTBP1 TLR7 16219795 1508158 Interleukin-12 (IL-12) is a heterodimeric cytokine produced by [dendritic cells (DCs)] in *response* to ligation . Regulation PTBP1 TLR7 17508961 1745147 Activation of TLRs by administration of specific bacterial ligands , in particular lipopolysaccharide , can augment airway sensitization in mice , and there is evidence that this process involves *dependent* activation of [DCs] . Regulation PTBP1 TLR7 17548596 1752209 Produced by [dendritic cells (DCs)] in *response* to ligands , IL-27 recently emerged as a key regulator of inflammatory responses . Regulation PTBP1 TLR7 17906627 1812484 Two specific and structurally different inhibitors of the MK Rsk suppressed TLR induced endocytosis , thus defining in [DCs] a specific requirement for MKs in *responses* . Regulation PTBP1 TLR7 18824534 1987786 Rather , it has been shown that helminth products such as soluble egg antigens ( SEA ; a soluble extract from Schistosoma mansoni eggs ) inhibit the activation of [DCs] in *response* to classical ligands such as lipopolysaccharide or CpG . Regulation PTBP1 TLR7 19836139 2196457 Additionally , saliva treated [DCs] also presented a similar pattern of cytokine modulation in *response* to other ligands . Regulation PTBP1 TLR7 20200270 2229554 In *response* to signaling , conventional [DCs] can also produce IFN-beta but not IFN-alpha in a type I IFN independent manner . Regulation PTBP1 TLR7 21690322 2455680 DCs are important primary targets of TSLP , and we unexpectedly demonstrated that [DCs] also produce TSLP in *response* to stimulation and that this is augmented by IL-4 . Regulation PTBP1 TLR7 23257360 2724828 Given the expansion of CD11c+ DCs during the progression of atherosclerosis and the key role of T cell activation in atherogenesis , we sought to understand the *role* of signaling in CD11c+ [DCs] in atherosclerosis . Regulation PTBP1 TNF 12822512 1104258 Because TNF-alpha has been shown to induce the activation and maturation of dendritic cells (DCs) , we investigated the *effect* of secreted by transduced cells ( 32DTNF-alpha cells ) on the activation of [DCs] and their role in the production of antileukemic cytotoxic T lymphocytes ( CTLs ) . Regulation PTBP1 TNF 8542932 338771 We show that the *dependent* ex vivo generation of [DCs] from mobilized CD34+ cells is 2.5-fold enhanced by flk-2/flt-3 ligand or c-kit ligand ( stem cell factor ) and five-fold enhanced by a combination of these growth factors . Regulation PTBP2 CCL17 22057112 2540299 The direct *effects* of on [DCs] and the indirect effects on differentiation of T helper ( Th ) cells were determined in vitro and ex vivo . Regulation PTBP2 CD14 9680340 521003 Cultures enriched in *dependent* [DCs] were more potent stimulators of a mixed leukocyte reaction , compared with control GTS cultures containing both types of DCs . Regulation PTBP2 CD14 9680340 521015 Although TNF is required to ensure the institution of DC hematopoiesis from CD34 ( + ) progenitor cells , its activity on a later progenitor appears to limit the development of *dependent* [DCs] . Regulation PTBP2 FAS 21297009 2420020 The decrease in the numbers of CD8 ( + ) [DCs] required iNKT cells but was *independent* of perforin , , or IFN-? , as it was observed in mice deficient in each of these molecules . Regulation PTBP2 ITGAL 20530790 2315693 Although LFA-1 ( lymphocyte function associated antigen 1 ) on T cells is considered to be important for antigen-specific T-cell activation , the *role* for on [DCs] remains elusive . Regulation PTBP2 ITGB2 19234188 2040163 Taken together , one of the mechanisms of Treg mediated suppression functions across species and mediates an *dependent* interaction between Tregs and [DCs] . Regulation PTBP2 ITGB2 23817428 2815796 Therefore , our results indicate that *dependent* interactions between T cells and [DCs] play a crucial role not only in supporting firm arrest during Ag recognition but also in facilitating the Ag scanning processes . Regulation PTBP2 MUC16 15944279 1416048 We have investigated whether a released by tumor cells could be *involved* in causing these immunomodulating effects on [DCs] . Regulation PTBP2 TLR7 16219795 1508128 Interleukin-12 (IL-12) is a heterodimeric cytokine produced by [dendritic cells (DCs)] in *response* to ligation . Regulation PTBP2 TLR7 17508961 1745117 Activation of TLRs by administration of specific bacterial ligands , in particular lipopolysaccharide , can augment airway sensitization in mice , and there is evidence that this process involves *dependent* activation of [DCs] . Regulation PTBP2 TLR7 17548596 1752179 Produced by [dendritic cells (DCs)] in *response* to ligands , IL-27 recently emerged as a key regulator of inflammatory responses . Regulation PTBP2 TLR7 17906627 1812454 Two specific and structurally different inhibitors of the MK Rsk suppressed TLR induced endocytosis , thus defining in [DCs] a specific requirement for MKs in *responses* . Regulation PTBP2 TLR7 18824534 1987756 Rather , it has been shown that helminth products such as soluble egg antigens ( SEA ; a soluble extract from Schistosoma mansoni eggs ) inhibit the activation of [DCs] in *response* to classical ligands such as lipopolysaccharide or CpG . Regulation PTBP2 TLR7 19836139 2196427 Additionally , saliva treated [DCs] also presented a similar pattern of cytokine modulation in *response* to other ligands . Regulation PTBP2 TLR7 20200270 2229550 In *response* to signaling , conventional [DCs] can also produce IFN-beta but not IFN-alpha in a type I IFN independent manner . Regulation PTBP2 TLR7 21690322 2455640 DCs are important primary targets of TSLP , and we unexpectedly demonstrated that [DCs] also produce TSLP in *response* to stimulation and that this is augmented by IL-4 . Regulation PTBP2 TLR7 23257360 2724798 Given the expansion of CD11c+ DCs during the progression of atherosclerosis and the key role of T cell activation in atherogenesis , we sought to understand the *role* of signaling in CD11c+ [DCs] in atherosclerosis . Regulation PTBP2 TNF 12822512 1104255 Because TNF-alpha has been shown to induce the activation and maturation of dendritic cells (DCs) , we investigated the *effect* of secreted by transduced cells ( 32DTNF-alpha cells ) on the activation of [DCs] and their role in the production of antileukemic cytotoxic T lymphocytes ( CTLs ) . Regulation PTBP2 TNF 8542932 338765 We show that the *dependent* ex vivo generation of [DCs] from mobilized CD34+ cells is 2.5-fold enhanced by flk-2/flt-3 ligand or c-kit ligand ( stem cell factor ) and five-fold enhanced by a combination of these growth factors . Regulation PTEN CCND1 16849370 1600332 We have shown that [PTEN] localizes to the nucleus coincident with the G0-G1 phases of the cell cycle and that compartmentalization may *regulate* cell cycle progression dependent upon the down-regulation of . Regulation PTEN FOXO1 23060044 2763556 Luciferase assays were used to determined the transactivity and the direct *regulation* of [PTEN-3'-UTR] by miR-153 . Regulation PTEN ID1 19079342 2030886 negatively *regulated* both p53 and [PTEN] at the transcriptional level . Regulation PTEN ID1 19079342 2030891 In promoter assay with serial deletion and chromatin immunoprecipitation assay , the binding of p53 to the PTEN promoter was reduced by Id-1 , suggesting that *regulates* [PTEN] transcription through its p53 modulation . Regulation PTEN PTGER2 15539459 1360650 Increased [PTEN] activity in *response* to stimulation is associated with decreased tyrosine phosphorylation on PTEN , a mechanism known to regulate enzyme activity . Regulation PTEN TNF 14984207 1214669 Furthermore , [PTEN] expression strongly decreased MMP-9 promoter activity in *response* to . Regulation PTGER1 IL1B 9352015 461207 Based on these results , it is proposed that and IL-4 may be *involved* in the initiation and promotion of labor by inducing [EP1] levels and PGE2 production in amnion . Regulation PTGER1 IL1B 9916962 587593 The results of this study show that might be *involved* in infection induced preterm labor by interfering with the normal regulation of [EP1] receptor levels and with the promotion of increased PGE2 production in amnion tissue . Regulation PTGER2 CD38 16619484 1551245 The *effects* of , c12-CLA and c9,t11-CLA on proliferation , as well as COX-2 and [EP2] protein expression in canine mammary normal and cancerous cells , were detected by CellTiter 96 AQueous assay and Western blot assay , respectively . Regulation PTGER2 CGA 18543285 2010446 Thus , this study reports for the first time in mares that the ovulatory process is accompanied by the *dependent* up-regulation of [PTGER2] and PTGER4 , which may in turn regulate PGE2 mediated preovulatory effects . Regulation PTGER2 CGB8 18543285 2010445 Thus , this study reports for the first time in mares that the ovulatory process is accompanied by the *dependent* up-regulation of [PTGER2] and PTGER4 , which may in turn regulate PGE2 mediated preovulatory effects . Regulation PTGER2 DOCK2 23318649 2752917 is a guanyl nucleotide exchange factor expressed exclusively in microglia in the brain and is *regulated* by PGE2 receptor [EP2] . Regulation PTGER2 PRKACB 14527510 1148879 The inhibitory effect of PGE2 is mediated by the [EP2] and EP4 receptors , and *involves* both signaling and mediation by DC-derived IL-10 . Regulation PTGER2 PRKACG 14527510 1148880 The inhibitory effect of PGE2 is mediated by the [EP2] and EP4 receptors , and *involves* both signaling and mediation by DC-derived IL-10 . Regulation PTGER2 PRKAR1A 14527510 1148881 The inhibitory effect of PGE2 is mediated by the [EP2] and EP4 receptors , and *involves* both signaling and mediation by DC-derived IL-10 . Regulation PTGER2 PRKAR1B 14527510 1148882 The inhibitory effect of PGE2 is mediated by the [EP2] and EP4 receptors , and *involves* both signaling and mediation by DC-derived IL-10 . Regulation PTGER2 PRKAR2A 14527510 1148883 The inhibitory effect of PGE2 is mediated by the [EP2] and EP4 receptors , and *involves* both signaling and mediation by DC-derived IL-10 . Regulation PTGER2 PRKAR2B 14527510 1148884 The inhibitory effect of PGE2 is mediated by the [EP2] and EP4 receptors , and *involves* both signaling and mediation by DC-derived IL-10 . Regulation PTGER3 IL1B 9352015 461203 or IL-4 had no *effect* on [EP3] protein levels . Regulation PTGER4 IL1B 10800959 690453 In a first set of experiments , animals were treated with the inhibitor of PG synthesis ketorolac to determine the endogenous contribution of PG in mediating the neuronal activation and [EP4] expression in *response* to circulating . Regulation PTGES EPHB2 19299480 2106087 In the present study , we demonstrate that CGRP is involved in morphine tolerance by differentially regulating the *dependent* up-regulation of IL-1beta , TNF-alpha , and [microsomal prostaglandin E synthase-1] ( mPGES-1 ) in astrocytes and p38 dependent up-regulation of IL-6 in microglia in the rat spinal cord . Regulation PTGES IL1B 15457451 1301461 To study [mPGES-1] synthesis in human cartilage and its *regulation* by , we used human cartilage and an immortalized human chondrocyte cell line . Regulation PTGES IL1B 15531909 1367466 Induction of [mPGES-1] expression in *response* to was seen in cultured gastric fibroblasts in vitro , and double immunostaining showed mPGES-1 coexpression with COX-2 in fibroblasts of the ulcer bed in vivo . Regulation PTGES IL1B 16183115 1546788 The *effect* of on [mPGES-1] and COX-2 co-localization , such as would occur with infection , and the regulatory effects of pro-inflammatory cytokines IL-1beta and TNF-alpha on transcriptional activity of mPGES-1 and COX-2 in these cells were also studied . Regulation PTGES IL1B 16277686 1480512 EMSA and TransAM analyses demonstrated that mutated IkappaBalpha almost completely suppressed the stimulating *effect* of on [mPGES-1] expression and PGE2 production , whereas 15d-PGJ2 inhibited NF-kappaB transactivation . Regulation PTGES TNF 15642051 1363020 Treatment of gingival fibroblasts with triclosan ( 1 microg/ml ) significantly reduced the stimulatory *effect* of ( 10 ng/ml ) on the expression of [mPGES-1] at both the mRNA and the protein level by an average of 21 % and 43 % , respectively , and subsequently the production of PGE2 ( p < 0.01 ) . Regulation PTGES TNF 21435451 2406394 In *response* to ( TNF-a ) , IL-1ß , and cocultured lymphocytes , however , [mPGES-1] and COX-2 protein expression increased in fibroblasts and smooth muscle cells , accompanied by increased PGE ( 2 ) , whereas mPGES-2 and cPGES were unaffected . Regulation PTGES TNF 22227567 2550713 Matrix metalloproteinase dependent [microsomal prostaglandin E synthase-1] expression in macrophages : *role* of and the EP4 prostanoid receptor . Regulation PTGES2 IL1B 15225371 1264971 Expression of cPGES , [mPGES-2] , and COX-1 mRNA was not *affected* by or TNF-alpha . Regulation PTGES2 IL1B 17035941 1649230 No *effect* of on COX-1 , cytosolic PGES , or [mPGES-2] expression was observed . Regulation PTGES2 TNF 15225371 1264970 Expression of cPGES , [mPGES-2] , and COX-1 mRNA was not *affected* by IL-1beta or . Regulation PTGES3 IFI27 14612944 1163386 In this study , using the recombinant adenoviral vector expressing p27KIP1 ( Adp27KIP1 ) , we investigated whether *affects* [telomerase] activity in malignant glioma U373-MG cells . Regulation PTGES3 IL1B 14671209 1178372 Neither nor TNF-alpha *affected* [cPGES] in either VT or CT cells . Regulation PTGES3 IL1B 15225371 1264969 Expression of [cPGES] , mPGES-2 , and COX-1 mRNA was not *affected* by or TNF-alpha . Regulation PTGES3 TNF 14671209 1178371 Neither IL-1beta nor *affected* [cPGES] in either VT or CT cells . Regulation PTGES3 TNF 15225371 1264968 Expression of [cPGES] , mPGES-2 , and COX-1 mRNA was not *affected* by IL-1beta or . Regulation PTGS1 IL1B 10065947 593533 Neither , TNFalpha , nor the combination of these two cytokines *affected* [COX-1] mRNA levels . Regulation PTGS1 IL1B 11401839 824654 did not *affect* [COX-1] expression , activity , and localization . Regulation PTGS1 IL1B 11686835 875882 In contrast , had no *effect* on the level of the constitutively expressed [COX-1] . Regulation PTGS1 IL1B 12193539 981336 Our data indicate that endogenous progenitor [COX1] mRNA levels are low and are not *regulated* by . Regulation PTGS1 IL1B 17035941 1649231 No *effect* of on [COX-1] , cytosolic PGES , or mPGES-2 expression was observed . Regulation PTGS1 IL1B 8280164 240573 *Effects* of transforming growth factor beta and on expression of [cyclooxygenase 1] and 2 and phospholipase A2 mRNA in lung fibroblasts and endothelial cells in culture . Regulation PTGS1 IL1B 8872612 389704 Prostaglandin E2 , transforming growth factor-beta , and variably *regulate* the expression of [cyclooxygenase 1] , cyclooxygenase 2 , and lysyl oxidase in IMR90 , human embryo lung fibroblasts . Regulation PTGS1 PTGER2 9779823 540437 Role of receptors and cAMP in prostaglandin E2 *regulated* expression of type I collagen alpha1 , lysyl oxidase , and [cyclooxygenase-1] genes in human embryo lung fibroblasts . Regulation PTGS1 TNF 10065947 593532 Neither IL-1beta , , nor the combination of these two cytokines *affected* [COX-1] mRNA levels . Regulation PTGS1 TNF 9388257 466804 Neither [COX1] nor COX2 protein levels were *affected* by or PKA activators used alone , whereas in association , marked up-regulation of COX2 mRNA and protein was observed . Regulation PTGS2 CTGF 21352962 2453148 However , the *effect* of on migration activity and [COX-2] expression in human oral cells is mostly unknown . Regulation PTGS2 EPHB2 10922992 717904 Inhibition of activation had no *effect* on [COX-2] expression . Regulation PTGS2 EPHB2 11085935 750659 The potential *role* of in [PGHS-2] up-regulation was assessed by using cell lines expressing , both stably and after adenoviral infection , constitutively active forms of its upstream activator MAPK/ERK kinase ( MEK1 ) . Regulation PTGS2 EPHB2 11439356 833221 *Role* of p38 MAP kinases and in mediating ultraviolet-B induced [cyclooxygenase-2] gene expression in human keratinocytes . Regulation PTGS2 EPHB2 11520057 851898 *Involvement* of and protein tyrosine phosphatase signaling pathways in EGCG induced [cyclooxygenase-2] expression in Raw 264.7 cells . Regulation PTGS2 EPHB2 14998726 1216709 *Involvement* of AND p38 MAP kinase in AAPH induced [COX-2] expression in HaCaT cells . Regulation PTGS2 EPHB2 15300199 1283636 ERK inhibition by U1026 enhanced endotoxin induced production of COX-2 , consistent with negative *regulation* of [COX-2] by . Regulation PTGS2 EPHB2 15525649 1359909 Inhibition of activation by U0126 or PD98059 significantly decreased EGF dependent COX-2 expression , but did not *affect* Ang II-dependent [COX-2] expression . Regulation PTGS2 HBEGF 21071513 2354734 Also contributing to *regulation* of [COX-2] expression are the activities of both c-jun-N-terminal kinase and the MIF interacting protein , Jab1/CSN5 . Regulation PTGS2 HSD11B2 15718388 1402867 These data indicate that [COX-2] plays a modulating role in the development of hypertension due to 11betaHSD2 deficiency and that <11betaHSD2> *regulates* renal COX-2 expression by preventing glucocorticoid access to MRs during postnatal development . Regulation PTGS2 IFI27 11756433 916236 These data suggest that [COX-2] inhibits mesangial cell proliferation by a novel mechanism that is independent of prostaglandin synthesis , but *involves* p53 , p21 ( cip-1 ) , and ( kip-1 ) . Regulation PTGS2 IFI27 15287038 1278094 *Effects* of p53 or overexpression on [cyclooxygenase-2] gene expression in head and neck squamous cell carcinoma cell lines . Regulation PTGS2 IL1B 10084970 599230 Glucocorticoid receptor mediated post-ceramide inhibition of the *dependent* induction of ovarian [prostaglandin endoperoxide synthase-2] in rats . Regulation PTGS2 IL1B 10533051 562396 We have determined the role of PAF in the *regulation* of [cyclooxygenase-2 (COX-2)] and inducible nitric oxide synthase (iNOS) genes by in rat primary hippocampal cultures . Regulation PTGS2 IL1B 10533051 562397 Pretreatment with PAF antagonist BN50730 blocked induction of COX-2 mRNA by 2-hour IL-1beta treatment , and 2-hour treatment with the PAF analog mcPAF mimicked the *effects* of on [COX-2] mRNA levels . Regulation PTGS2 IL1B 10594073 573027 An essential *role* of in mediating NF-kappaB activity and [COX-2] transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia . Regulation PTGS2 IL1B 10810453 692771 Differential *regulation* of [cyclooxygenase-2 (COX-2)] mRNA stability by and tumor necrosis factor-alpha (TNF-alpha) in human in vitro differentiated macrophages . Regulation PTGS2 IL1B 10942208 721296 Since pro-inflammatory cytokine IL-1beta has been shown to induce prostaglandin E2 ( PGE2 ) release in human gingival fibroblasts (HGF) , here we analyzed the *effect* of on the expression of [COX-2] and the activation of NFkappaB in HGF . Regulation PTGS2 IL1B 11062012 746436 However , as ERK is not required for *dependent* induction of [COX-2] , the mechanism of ceramide and SMase induction of COX-2 remains unclear . Regulation PTGS2 IL1B 11112151 757531 PGE ( 2 ) increased adenylate cyclase activity in a concentration dependent manner , and forskolin , a direct activator of adenylate cyclase , caused a marked increase in *dependent* [COX-2] , suggesting the existence of a causal relationship between the two events . Regulation PTGS2 IL1B 11530235 853786 The signaling mechanisms by which *regulates* NOS-2 and [COX-2] genes remain obscure . Regulation PTGS2 IL1B 11530235 853794 However , rotenone inhibited NOS-2 and COX-2 proteins and associated nitric oxide and prostaglandin E ( 2 ) production , respectively , suggesting a posttranscriptional target for mediated *regulation* of NOS-2 and [COX-2] gene expression . Regulation PTGS2 IL1B 11934644 927811 This is evidenced by the fact that TENS at low magnitude : ( i ) inhibits recombinant human ( rh ) *dependent* induction of [cyclooxygenase-2 (COX-2)] mRNA expression and production of prostaglandin estradiol ( PGE2 ) ; Regulation PTGS2 IL1B 12107235 963033 To investigate the potential *effects* of on [COX-2] mRNA stability , ESC were treated with actinomycin D , a general transcription inhibitor , in the absence or presence of IL-1beta . Regulation PTGS2 IL1B 12124863 965846 To examine [cyclooxygenase-2 (COX-2)] enzyme expression , its *regulation* by , and the role of prostaglandin E ( 2 ) ( PGE ( 2 ) ) in proteoglycan degradation in human osteoarthritic ( OA ) cartilage . Regulation PTGS2 IL1B 12147254 970007 We investigated in this study the role of beta-catenin in the *regulation* of [COX-2] expression in articular chondrocytes . Regulation PTGS2 IL1B 14645533 1173018 Transcriptional *regulation* of [cyclooxygenase 2] by bradykinin and in human airway smooth muscle cells : involvement of different promoter elements , transcription factors , and histone h4 acetylation . Regulation PTGS2 IL1B 15016613 1257077 Western blot analysis of mucosal homogenates revealed dramatic upregulation of [COX-2] in *response* to or peritoneal PMNs , and the latter was inhibited by an IL-1beta receptor antagonist . Regulation PTGS2 IL1B 15016613 1257079 Real-time PCR revealed that increased mRNA COX-2 expression preceded increased [COX-2] protein expression in *response* to . Regulation PTGS2 IL1B 15016613 1257081 We concluded that PMNs augment recovery of TER in ischemia injured ileal mucosa via *dependent* upregulation of [COX-2] . Regulation PTGS2 IL1B 15111866 1241262 We further demonstrated that p38 MAPK is activated by IL-1beta and PDGF with different kinetics and that p38 MAPK is required for maximal [COX2] expression in *response* to plus PDGF-BB . Regulation PTGS2 IL1B 15124245 1242468 Both and TNF-a upregulated COX-2 mRNA comparably to IL-15 , but neither IL-2 nor interferon-g had any *effect* on the [COX-2] mRNA level . Regulation PTGS2 IL1B 15334456 1291069 In hypoxia , transcription of [cyclooxygenase 2 (COX-2)] , expression of COX-2 protein , and production of COX-2 derived eicosanoids and matrix metalloproteinase (MMP) activity by FLS were all increased in *response* to . Regulation PTGS2 IL1B 15483103 1359295 Distinct *regulation* of [cyclooxygenase-2] by in normal and endometriotic stromal cells . Regulation PTGS2 IL1B 15483103 1359300 Distinct *regulation* of [COX-2] gene by may play a critical role in pathophysiological processes such as cancer formation and endometriosis . Regulation PTGS2 IL1B 16183115 1546790 The *effect* of on mPGES-1 and COX-2 co-localization , such as would occur with infection , and the regulatory effects of pro-inflammatory cytokines IL-1beta and TNF-alpha on transcriptional activity of mPGES-1 and [COX-2] in these cells were also studied . Regulation PTGS2 IL1B 16210363 1501032 The mechanism involves blockade by IL-4 and interferon-gamma of the *dependent* activation of [PGHS-2] gene promoter activity . Regulation PTGS2 IL1B 16326073 1553756 Here , we have analyzed the *regulation* of [COX-2] by in the human colon carcinoma cell line Caco-2 , showing that COX-2 induction by this cytokine is due to both nuclear factor (NF)-kappaB dependent transcriptional and p38 mitogen activated protein kinase (MAPK) mediated post-transcriptional mechanisms . Regulation PTGS2 IL1B 16326073 1553832 p38 MAPK signalling was required for *dependent* stabilization of [COX-2] transcript . Regulation PTGS2 IL1B 17481552 1738703 In this review , we provide evidence for reduced [COX-2] transcriptional expression in *response* to phorbol esters ( PMA ) , lipopolysaccharide (LPS) , and tumor necrosis factor alpha (TNFalpha) . Regulation PTGS2 IL1B 17510310 1745190 Using RNA interference , we have reduced the expression of [COX-2] in the highly malignant breast cancer cell line MDA-MB-231 below detectable levels in *response* to or 12-O-tetradecanoylphorbol-13-acetate treatment . Regulation PTGS2 IL1B 18432307 1900167 The aim of the present study was to determine the *effect* of tumor necrosis factor-alpha (TNF-alpha) , and interleukin-6 (IL-6) on prostaglandin (PG)F ( 2 alpha ) and PGE ( 2 ) secretion as well as [cyclooxygenase-2 (COX-2)] protein expression in chorioamnion collected on days 25 , 30 and 40 of pregnancy in pigs . Regulation PTGS2 IL1B 19227129 2007368 The aim of the present study was to determine the *effect* of tumor necrosis factor-alpha (TNF-alpha) , and interleukin-6 (IL-6) on prostaglandin (PG)F2alpha and PGE2 secretion as well as on [cyclooxygenase-2 (COX-2)] protein expression in maternal placenta collected on days 25 , 30 and 40 of pregnancy in pigs . Regulation PTGS2 IL1B 19444894 2096678 Ex vivo analysis indicates is *responsible* for the activation of the [COX-2] / PGE2 pathway . Regulation PTGS2 IL1B 19452719 2084475 [ *Effect* of hypoxia and on [COX-2] expression and PGE2 release in human nasal epithelia ] . Regulation PTGS2 IL1B 20424388 2262546 Identification of cells expressing [cyclooxygenase-2] in *response* to in rat aortae . Regulation PTGS2 IL1B 20717505 2306735 AF pellet resulted in dose dependent iNOS and [COX-2] expression in *response* to , stimulation , demonstrating that 1 ng/ml for 24 hours yielded a maximal response . Regulation PTGS2 IL1B 20717505 2306739 AF pellet in NCCM significantly decreased the expression of iNOS and [COX-2] in *response* to 1ng/ml , stimulation at 24 hours ( p < 0.05 ) . Regulation PTGS2 IL1B 21683339 2494280 *affects* [cyclooxygenase-2] expression and cartilage metabolism in mandibular condyle . Regulation PTGS2 IL1B 7637265 317513 *regulates* rat mesangial [cyclooxygenase II] gene expression by tyrosine phosphorylation . Regulation PTGS2 IL1B 8711133 371298 In this study , the *effect* of on cPLA2 and [PGHS-2] mRNA expression was investigated . Regulation PTGS2 IL1B 8872612 389708 Prostaglandin E2 , transforming growth factor-beta , and variably *regulate* the expression of cyclooxygenase 1 , [cyclooxygenase 2] , and lysyl oxidase in IMR90 , human embryo lung fibroblasts . Regulation PTGS2 IL1B 8908620 394510 Besides it seems likely that endogenously produced may be *involved* in autocrine or paracrine fashion in inducing [COX-2] after the onset of labor . Regulation PTGS2 IL1B 9003387 404830 A detailed analysis of the individual *effects* of IgE/antigen , IL-10 and on [COX-2] expression revealed that IgE/antigen and IL-10 each initiated and stabilized COX-2 mRNA expression , leading to an increase in the expression of its protein . Regulation PTGS2 IL1B 9179403 434358 *Effect* of , tumour necrosis factor-alpha and interferon-gamma on the induction of [cyclo-oxygenase-2] in cultured human airway smooth muscle cells . Regulation PTGS2 IL1B 9815044 546503 These results indicate that COX-2 protein is highly localized in the base of gastric ulcers in rats and that [COX-2] mRNA expression might be *regulated* positively by and TNF-alpha and negatively by TGF-beta1 . Regulation PTGS2 IL1B 9931117 589016 *regulation* of inducible nitric oxide synthase and [cyclooxygenase-2] involves the p42/44 and p38 MAPK signaling pathways in cardiac myocytes . Regulation PTGS2 IL6R 19277492 2135422 These results indicate that interleukin-6/soluble complexes and the signal transducer 130-kDa glycoprotein *play* an important role in the regulation of [cyclooxygenase-2] expression and subsequent prostaglandin E ( 2 ) formation in mouse astrocytes and that interleukin-6 is an important regulator of immune and inflammatory processes in the CNS . Regulation PTGS2 PTGER2 17277233 1797613 Prostaglandin receptor is *responsible* for [cyclooxygenase-2] induction by prostaglandin E2 in mouse skin . Regulation PTGS2 RARB 11821953 908918 The inhibitory *effect* of on [COX-2] expression was further enhanced in the presence of RA , which was blocked by an RAR antagonist . Regulation PTGS2 S100B 12837757 1134699 In this study , we investigated the *effect* of AGEs and , a specific RAGE ligand , on the expression of [COX-2] and the molecular mechanisms involved in cultured THP-1 monocytes and human peripheral blood monocytes . Regulation PTGS2 SRGN 19123332 2004910 To investigate the *effects* of on serum inflammatory factors and protein expression of [cyclooxygenase-2 (COX-2)] and intercellular adhesion molecule-1 ( ICAM-1 ) in ischemic myocardium of rats with acute myocardial infarction ( AMI ) . Regulation PTGS2 TGM2 24009824 2714633 These observations suggested that is *involved* in TPA induced [COX-2] expression in the inflamed ear of mice and anti-inflammatory effects of glucosamine is mediated through suppression of Tgase-2 in TPA ear edema . Regulation PTGS2 TNF 10631313 659776 We showed that the compound suppressed the *dependent* [cyclooxygenase-2] induction with an IC ( 50 ) of as low as about 30 nM as demonstrated experimentally by catalytic activity assay , Northern blot analysis and promoter analysis . Regulation PTGS2 TNF 10718111 579356 A rapid increase in [PGHS-2] ( but not PGHS-1 ) mRNA expression was observed in *response* to and IL-1beta . Regulation PTGS2 TNF 10810453 692770 Differential *regulation* of [cyclooxygenase-2 (COX-2)] mRNA stability by interleukin-1 beta (IL-1 beta) and in human in vitro differentiated macrophages . Regulation PTGS2 TNF 12017180 942403 In contrast , PGE2 or indomethacin failed to modify the stimulatory *effect* of IL-1alpha or on [COX-2] gene expression . Regulation PTGS2 TNF 12669881 1075930 The aim of the present study was to investigate the *effects* of interleukin (IL)-1alpha and on the expression of [COX-2] mRNA gene and protein in cultured human pulp cells . Regulation PTGS2 TNF 12890694 1117658 The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates [COX-2] induction and PGE2 production in *response* to . Regulation PTGS2 TNF 13679315 1185647 Moreover , the stimulatory *effect* of ( 0.6 nM ) on [COX-2] gene expression was completely blocked by IFNtau ( 30 ng/ml ; Regulation PTGS2 TNF 14592548 1159954 *regulates* renal [COX-2] in the rat thick ascending limb (TAL) . Regulation PTGS2 TNF 15124245 1242467 Both IL-1beta and upregulated COX-2 mRNA comparably to IL-15 , but neither IL-2 nor interferon-g had any *effect* on the [COX-2] mRNA level . Regulation PTGS2 TNF 15229940 1269042 Upregulation of synoviocyte [COX-2] through interactions with T lymphocytes : *role* of interleukin 17 and . Regulation PTGS2 TNF 15649409 1363827 The inhibition of *dependent* induction of [COX-2] expression was mediated by an inhibition of NF-kappaB activation . Regulation PTGS2 TNF 15728492 1377296 *Involvement* of and NF-kappa B in the transcriptional control of [cyclooxygenase-2] expression by IFN-gamma in macrophages . Regulation PTGS2 TNF 17384033 1715825 Pre-treatment with pyrolidine dithiocarbamate ( PDTC ) , one of the NF-kappaB inhibitors , prevented binding to the [COX-2] promoter and expression of COX-2 protein in *response* to . Regulation PTGS2 TNF 17481552 1738702 In this review , we provide evidence for reduced [COX-2] transcriptional expression in *response* to phorbol esters ( PMA ) , lipopolysaccharide (LPS) , interleukin-1beta (IL-1beta) and . Regulation PTGS2 TNF 17708399 1783067 In addition , a neoplastic and a nonneoplastic canine prostatic cell line were used to investigate the *effects* of interleukin-6 (IL-6) , , phorbol 12-myristate 13-acetate ( PMA ) , epithelial growth factor (EGF) , and specific signal transduction pathway inhibitors on [COX-2] expression . Regulation PTGS2 TNF 20585313 2320397 in contrast , ErbB4 knockdown with siRNA blocked [COX-2] accumulation in *response* to . Regulation PTGS2 TNF 21435451 2406396 In *response* to ( TNF-a ) , IL-1ß , and cocultured lymphocytes , however , mPGES-1 and [COX-2] protein expression increased in fibroblasts and smooth muscle cells , accompanied by increased PGE ( 2 ) , whereas mPGES-2 and cPGES were unaffected . Regulation PTGS2 TNF 22800939 2645769 The *effect* of on [cyclooxygenase-2 (COX-2)] expression in the renal outer medulla ( OM ) was determined in a model of dihydrotachysterol ( DHT ) -induced hypercalcemia . Regulation PTGS2 TNF 24133591 2853390 Among four kinds of cytokines , IL-1ß treatment increased COX-2 protein expression and VEGF release in three ESC , and had the same *effect* on [COX-2] protein level as IL-1ß only in ectopic and eutopic ESC , and MCSF had only slight effect on ectopic ESC . Regulation PTGS2 TNF 9330943 457561 TNF-R55 is the major receptor isoform transducing PGE2 and [COX-2] *responses* to in OA synovial fibroblasts ; Regulation PTGS2 TNF 9388257 466811 Neither COX1 nor [COX2] protein levels were *affected* by or PKA activators used alone , whereas in association , marked up-regulation of COX2 mRNA and protein was observed . Regulation PTGS2 TNF 9576062 502805 mediated *regulation* of [prostaglandin endoperoxide synthase-2] ( PGHS-2 ) mRNA levels was examined in murine fibrosarcoma MCA-101 cells . Regulation PTGS2 TNF 9576062 502809 We suggest that PTPs and PTKs play a role in the transcriptional and/or post-transcriptional mechanisms that contribute to the *regulation* of the [PGHS-2] gene by . Regulation PTGS2 TNF 9632078 512588 *Regulation* of [cyclooxygenase-2] expression in bovine chondrocytes in culture by interleukin 1alpha , , glucocorticoids , and 17beta-estradiol . Regulation PTGS2 TNF 9815044 546502 These results indicate that COX-2 protein is highly localized in the base of gastric ulcers in rats and that [COX-2] mRNA expression might be *regulated* positively by IL-1beta and and negatively by TGF-beta1 . Regulation PTH EPHB2 23197743 2745428 We conclude that [PTH] regulation of osteoblast mineralization in female mice is maturation stage specific and *involves* MKP1 modulation of and P-p38 MAPKs . Regulation PTH IL1B 9325185 456744 This study demonstrates a direct *effect* in vitro of on [PTH] secretion from bovine parathyroid glands , an effect which may be mediated at least in part through the specific IL-1 receptor causing an upregulation of the calcium sensing receptor mRNA . Regulation PTH ITGB2 12402981 1009564 In a coculture system of murine spleen cells and osteoblasts , the interaction was also *involved* in 1,25D- , [PTH-] and IL-1alpha stimulated TRAP positive MNC formation . Regulation PTH RGS2 11968023 938209 Functional analysis using RGS-2 overexpression suggests the potential negative regulatory *effects* of on [PTH-] and forskolin induced cAMP production in osteoblastic cells . Regulation PTH RGS2 11996904 939172 Finally , we tested the *effect* of overexpression on [PTH-] and fluprostenol induced interleukin (IL)-6 promoter activity in MOB cells . Regulation PTH TCN1 23368947 2853726 This study examines the inhibitory *effects* of on lipopolysaccharide- , [parathyroid hormone (PTH)-] , and prostaglandin E2 ( PGE2 ) -induced expression of MMP-13 in UMR 106-01 cells , an osteoblastic osteosarcoma cell line . Regulation PTH TNF 10379905 623938 The *effects* of and interleukin-6 (IL-6) on [parathyroid hormone (PTH)] secretion were investigated . Regulation PTH TNF 10379905 623942 IL-6 and had no acute *effect* on [PTH] secretion in extracellular Ca2+ concentrations of 0.5 , 1.25 and 3.0 mM . Regulation PTH TNF 14664720 1177715 had no *effect* on PTH secretion , and [PTH] and CaR mRNA expression . Regulation PTH1R MAP2K6 12606410 1064544 The nitric oxide mediated increase of [P-Thr-Glu-Tyr-P] *involved* protein Tyr kinase , or MEK-like kinase , and protein kinase C but not protein kinase A . Regulation PTK2 EDN2 8631827 357215 In contrast , tyrosine phosphorylation of [p125FAK] and paxillin in *response* to bombesin , , and phorbol 12,13-dibutyrate was not inhibited by wortmannin in these cells . Regulation PTK2 FAS 9558114 500055 These findings suggest that H2O2 induces up-regulation of in ECs and that activation of [protein tyrosine kinase] may be *involved* in the mechanism of H2O2 induced Fas expression . Regulation PTK2 PECAM1 22000807 2503097 Syk [protein tyrosine kinase] *involves* signaling through tandem immunotyrosine inhibitory motifs in human THP-1 macrophages . Regulation PTK2 TNF 10385397 625429 These observations suggest that the stimulatory *effect* of on LDH A mRNA expression requires protein synthesis and may involve a [protein tyrosine kinase] and protein kinase C . Regulation PTK6 FAS 9558114 500056 These findings suggest that H2O2 induces up-regulation of in ECs and that activation of [protein tyrosine kinase] may be *involved* in the mechanism of H2O2 induced Fas expression . Regulation PTK6 PECAM1 22000807 2503098 Syk [protein tyrosine kinase] *involves* signaling through tandem immunotyrosine inhibitory motifs in human THP-1 macrophages . Regulation PTK6 TNF 10385397 625430 These observations suggest that the stimulatory *effect* of on LDH A mRNA expression requires protein synthesis and may involve a [protein tyrosine kinase] and protein kinase C . Regulation PTK7 FAS 9558114 500057 These findings suggest that H2O2 induces up-regulation of in ECs and that activation of [protein tyrosine kinase] may be *involved* in the mechanism of H2O2 induced Fas expression . Regulation PTK7 PECAM1 22000807 2503099 Syk [protein tyrosine kinase] *involves* signaling through tandem immunotyrosine inhibitory motifs in human THP-1 macrophages . Regulation PTK7 TNF 10385397 625431 These observations suggest that the stimulatory *effect* of on LDH A mRNA expression requires protein synthesis and may involve a [protein tyrosine kinase] and protein kinase C . Regulation PTN TMEM100 20036837 2192381 [Pleiotrophin-PTPzeta] signaling *regulates* the morphogenesis of Purkinje cell by controlling the tyrosine phosphorylation of a Notch related , DNER . Regulation PTN TMEM156 20036837 2192399 [Pleiotrophin-PTPzeta] signaling *regulates* the morphogenesis of Purkinje cell by controlling the tyrosine phosphorylation of a Notch related , DNER . Regulation PTN TMEM211 20036837 2192479 [Pleiotrophin-PTPzeta] signaling *regulates* the morphogenesis of Purkinje cell by controlling the tyrosine phosphorylation of a Notch related , DNER . Regulation PTN TMEM213 20036837 2192416 [Pleiotrophin-PTPzeta] signaling *regulates* the morphogenesis of Purkinje cell by controlling the tyrosine phosphorylation of a Notch related , DNER . Regulation PTPLA EPHB2 20440482 2288112 Ca ( OH ) ( 2 ) stimulated expression of the cementum-specific proteins CEMP1 and [PTPLA/CAP] in an *dependent* manner . Regulation PTPN1 TNF 21483233 2562078 In the present study , we sought to identify the mechanism of *regulated* hepatic [PTP-1B] expression and evaluate the effect of rosiglitazone on TNF-a induced hepatic PTP-1B upregulation . Regulation PTPN11 CAPN8 20398180 2245952 These results suggest that *dependent* cleavage of SHP-1 and [SHP-2] may contribute to protein tyrosine dephosphorylation in Jurkat T cell death induced by E. histolytica . Regulation PTPN11 CCND1 11502738 868268 Taken together , these findings demonstrate that Ang II-induced up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a p21(ras)/Raf-1/MEK/ERK dependent manner , and also *involves* PI3K and [SHP-2] . Regulation PTPN11 EPHB2 11502738 868269 Taken together , these findings demonstrate that Ang II-induced cyclin D1 up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a *dependent* manner , and also involves PI3K and [SHP-2] . Regulation PTPN11 EPHB2 20493809 2263561 By comparing shp2-deficient zebrafish embryos with those injected with mRNA encoding LEOPARD syndrome point mutations , we identify a phosphatase- and *dependent* role for [Shp2] in neural crest specification and migration . Regulation PTPN11 MAP2K6 11502738 868277 Taken together , these findings demonstrate that Ang II-induced cyclin D1 up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region , both in a *dependent* manner , and also involves PI3K and [SHP-2] . Regulation PTPN11 TNF 19287004 2072960 [SHP2] associated with ASK1 in *response* to in EC . Regulation PTPN6 CAPN8 20398180 2245966 These results suggest that *dependent* cleavage of [SHP-1] and SHP-2 may contribute to protein tyrosine dephosphorylation in Jurkat T cell death induced by E. histolytica . Regulation PTPN6 CAPN8 9813145 546257 Stimulation of platelets by the ionophore A23187 in the presence of CaCl2 induced a *dependent* cleavage of [SHP-1] . Regulation PTPN6 EPHB2 21044800 2370604 Collectively , these results suggest that [SHP-1] positively *regulates* IL-3 dependent mast cell proliferation and apoptosis by inhibiting activity through its phosphatase activity . Regulation PTPRC CD22 15240561 1295790 A novel approach for simultaneous biotinylation and cross linking showed that CD22 associates with [CD45] and sIgM at much higher levels than reported in prior studies , possibly *involving* cell surface multimers of . Regulation PTPRC ITGAL 7913942 266514 [CD45] mediated adhesion of activated T cells *involved* both dependent as well as CD11a/18 independent mechanisms . Regulation PTPRC ITGB2 8096435 214564 The *involvement* of and ICAM-1 in [CD45] mediated adhesion was supported by the observation that CD11a ( LFA-1 alpha ) mAb R7.1 , CD18 ( LFA-1 beta ) mAb R3.3 , and CD54 ( ICAM-1 ) mAb R6.1 or RR/l all strongly inhibited CD45- and PMA induced aggregation . Regulation PTPRC TLR7 16034093 1436271 We also observed that [CD4+CD45RO+] memory T cell *responses* to ligands were more potent than those observed with CD4+CD45RA+ naive T cells . Regulation PTS TNF 9788822 541909 Reverse-transcription/limiting-dilution polymerase chain reaction analysis showed that in *response* to , mRNA abundance of GTPCH and [PTPS] was increased approximately 64-fold and 10-fold , respectively . Regulation PTX3 IL1B 10606983 655880 Unlike the classical pentraxins , the long pentraxin [PTX3] is expressed in *response* to and tumour necrosis factor-alpha (TNF-alpha) , but not to IL-6 , in various cell types . Regulation PTX3 IL1B 14603263 1187575 The results are consistent with the reported *effects* of on [PTX3] expression in mouse brain . Regulation PTX3 IL1B 15344601 1292073 Unlike the classical pentraxins , [PTX3] is expressed in *response* to and TNF-alpha but not to IL-6 . Regulation PTX3 TLR7 15771574 1384419 [PTX3] is produced by a variety of cells and tissues , most notably dendritic cells and macrophages , in *response* to engagement and inflammatory cytokines . Regulation PTX3 TLR7 16461742 1540859 Dendritic cells ( DC ) of myelomonocytic origin , but not plasmacytoid DC , are a major source of [PTX3] in *response* to engagement . Regulation PTX3 TLR7 17023219 1647840 CRP and SAP are produced primarily in the liver in response to IL-6 , while [PTX3] is produced by a variety of tissues and cells and in particular by innate immunity cells in *response* to proinflammatory signals and engagement . Regulation PTX3 TLR7 17278387 1664544 [PTX3] is produced by a variety of cells and tissues , most notably dendritic cells and macrophages , in *response* to engagement and inflammatory cytokines . Regulation PTX3 TLR7 19449441 2078832 [PTX3] is produced by a variety of cells and tissues , most notably dendritic cells and macrophages , in *response* to engagement and inflammatory cytokines . Regulation PTX3 TLR7 21226667 2402451 CRP and SAP are produced primarily in the liver in response to IL-6 , while [PTX3] is produced by a variety of tissues and cells and in particular by innate immunity cells in *response* to proinflammatory signals and engagement . Regulation PTX3 TNF 10606983 655879 Unlike the classical pentraxins , the long pentraxin [PTX3] is expressed in *response* to IL-1beta and , but not to IL-6 , in various cell types . Regulation PTX3 TNF 15344601 1292072 Unlike the classical pentraxins , [PTX3] is expressed in *response* to IL-1beta and but not to IL-6 . Regulation PTX3 TNF 22447522 2719138 Neither soluble receptor ( etanercept ) nor recombinant IL-1 receptor antagonist *affected* [PTX3] production by SAA stimulated synoviocytes , suggesting that SAA directly induces PTX3 . Regulation PTX3 TNF 9521058 493685 PTX3 is a prototypic long [pentraxin] expressed by various cell types , most prominently monocytes and endothelial cells , in *response* to interleukin-1 (IL-1) , and bacterial products . Regulation PTX4 TNF 9521058 493684 PTX3 is a prototypic long [pentraxin] expressed by various cell types , most prominently monocytes and endothelial cells , in *response* to interleukin-1 (IL-1) , and bacterial products . Regulation PVR ARSA 3118440 80195 caused a slight rise in resting PVR ( p less than 0.05 ) , but did not *affect* the exercise induced decrease in [PVR] . Regulation PVRL1 EPHB2 20455254 2257274 Inhibition of PI3K/AKT or signalling did not *affect* the level of [nectin-1] expression but decreased thyroid cancer cell susceptibility to HSV . Regulation PXN CAPN8 12490576 1033343 The goal of the present study was to determine the *role* of in changes in plasma membrane permeability and cytoskeleton associated [paxillin] , vinculin , talin , and alpha-actinin levels during acute renal cell death . Regulation PXN EDN2 8631827 357218 In contrast , tyrosine phosphorylation of p125FAK and [paxillin] in *response* to bombesin , , and phorbol 12,13-dibutyrate was not inhibited by wortmannin in these cells . Regulation QRICH1 TGM2 11877487 919117 It is known that the enzyme is *involved* in the generation of T cell stimulatory gluten peptides through deamidation of [glutamine] , the most abundant amino acid in gluten . Regulation QRICH1 TNF 8651752 364632 The authors studied the *effects* of interleukin-6 (IL-6) and on [glutamine] and alanine transport in isolated human hepatocytes . Regulation QRICH2 TGM2 11877487 919118 It is known that the enzyme is *involved* in the generation of T cell stimulatory gluten peptides through deamidation of [glutamine] , the most abundant amino acid in gluten . Regulation QRICH2 TNF 8651752 364634 The authors studied the *effects* of interleukin-6 (IL-6) and on [glutamine] and alanine transport in isolated human hepatocytes . Regulation RAB23 RAB31 20375059 2245165 Differential role of proteins in ciliary trafficking : [Rab23] *regulates* smoothened levels . Regulation RAB31 GDI1 11116150 810752 These results suggest that membrane associated [Rab] may *regulate* recruitment of GDI-Rab from the cytosol , possibly by regulating a receptor . Regulation RAB31 GDI2 11116150 810753 These results suggest that membrane associated [Rab] may *regulate* recruitment of GDI-Rab from the cytosol , possibly by regulating a receptor . Regulation RAB31 HSP90AA1 12426384 1014514 [Rab-alphaGDI] activity is *regulated* by a chaperone complex . Regulation RAB31 RAB27A 16571673 1562322 Therefore , our work demonstrates that AEX-3 regulates both RAB-3 and RAB-27 , that both [RAB-3] and RAB-27 *regulate* synaptic transmission , and that potentially acts through its effector RBF-1 to promote soluble N-ethylmaleimide-sensitive factor attachment protein receptor ( SNARE ) function . Regulation RAB31 SLC2A4RG 21586568 2449629 We also found that serine to alanine substitutions in the sequences between SH2 and RIN family homology domain of RIN3 specifically abolished its *action* on [Rab31] but not Rab5 . Regulation RAB37 TNF 21805469 2495254 Taken together , these findings demonstrate that [Rab37] interacts with Munc13-1 to *control* secretion from activated macrophages . Regulation RABEPK EPHB2 16394015 1506056 Defective activation of in macrophages lacking the p50/p105 subunit of NF-kappaB is *responsible* for elevated expression of IL-12 [p40] observed after challenge with Helicobacter hepaticus . Regulation RABEPK PTGER2 23337716 2753646 These results can be explained by differential *regulation* of the common subunit , [IL-12p40] , and IL-23p19 , by and EP(4) . Regulation RABEPK TGM2 16382148 1505652 Here , we report that the Ca2+ dependent protein cross linking enzyme is *involved* in THG induced [p40] and p64 formation by catalyzing caspase 3 cross linking reactions , thereby inactivating caspase 3 and apoptosis in Bax-deficient cells . Regulation RABEPK TLR7 17521321 1767172 natural killer (NK)1.1 ( - ) CD11c ( + ) liver DC subsets ( conventional DCs , T cell receptor ( TcR ) beta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( - ) and plasmacytoid DCs , TcRbeta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( + ) ) efficiently endocytose dextran and produce significant levels of tumour necrosis factor (TNF)-alpha , interleukin (IL)-6 and IL-12 [p40] in *response* to ligands , with responses higher than splenic DCs . Regulation RABEPK TLR7 17981792 1845625 [IL-12p40] was also produced by poly ( A : U ) -stimulated pDC in a *dependent* manner . Regulation RABEPK TLR7 18276743 2010218 *dependent* induction of p19 , [p40] and bioactive IL23 was determined in RA synovial fibroblasts ( RASF ) , monocytes and monocyte derived dendritic cells ( MDDCs ) by real-time PCR and reverse transcriptase ( RT ) -PCR , Western blot and functional assays . Regulation RABEPK TLR7 19322177 2064506 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and [IL-12p40] ( also known as IL12b ) , but not TNF , in *response* to ligands . Regulation RABEPK TNF 16210605 1464423 TNFR1 was established as the main receptor involved in IL-12p40 regulation , because [IL-12p40] levels were not *affected* by in TNFR1 ( -/- ) -derived macrophages . Regulation RAC1 ANGPT1 22936663 2688018 This complex brings Par3 , Par6 , and adherens junction proteins at the front of migrating cells to locally activate [Rac1] in *response* to . Regulation RAC1 CCND1 15652748 1364333 Mechanistically , the effects of Vav1 require its GEF activity and the activation of [Rac1] , PAK1 , and NF-kappaB and *involve* upregulation . Regulation RAC1 EPHB2 12892714 1117835 signaling coordinately *regulates* activity of [Rac1] and RhoA for tumor cell motility . Regulation RAC1 EPHB2 17156131 1687193 Moreover , a blockade did not *affect* [Rac1] activity . Regulation RAC1 EPHB2 17363898 1720407 Second , ARF6 induced activation *regulates* [Rac1] activation during tubule initiation through the expression of the receptor for urokinase type plasminogen activator . Regulation RAC1 EPHB2 20526801 2320127 In this study , we investigated whether *regulates* [Rac1/Pak1] signaling and is critically linked to MB cell migration . Regulation RAC1 FAS 18676874 1967453 This study examined a potential role of paxillin in the feedback mechanism of [Rac] *regulation* by in OxPAPC stimulated ECs . Regulation RAC1 MAP2K6 17156131 1687199 Moreover , a blockade did not *affect* [Rac1] activity . Regulation RAC1 PLAU 12719789 1084093 Endogenous RhoA , but not [Rac1] or Cdc42 , was significantly activated in *response* to . Regulation RAC1 S1PR3 12069818 955561 Consistent with this , Edg1 and , and Edg5 *regulate* the activity of the Rho family GTPase [Rac] positively and negatively , respectively . Regulation RAC1 SLC6A2 23184663 2723833 [Rac1] *controls* the subcellular localization of the Rho guanine nucleotide exchange factor to regulate focal adhesion formation and cell spreading . Regulation RAC1 TNF 23639811 2805081 Cumulatively , these results demonstrate that NOX2 and its activator subunits ( p47phox and [Rac] ) *control* the secretion of by the liver following I/R. Interestingly , in the absence of Kupffer cells and NOX2 , NOX1 played a dominant role in TNF-a production following hepatic I/R . Regulation RAC2 FAS 18676874 1967454 This study examined a potential role of paxillin in the feedback mechanism of [Rac] *regulation* by in OxPAPC stimulated ECs . Regulation RAC2 S1PR3 12069818 955564 Consistent with this , Edg1 and , and Edg5 *regulate* the activity of the Rho family GTPase [Rac] positively and negatively , respectively . Regulation RAC2 TNF 23639811 2805082 Cumulatively , these results demonstrate that NOX2 and its activator subunits ( p47phox and [Rac] ) *control* the secretion of by the liver following I/R. Interestingly , in the absence of Kupffer cells and NOX2 , NOX1 played a dominant role in TNF-a production following hepatic I/R . Regulation RAC3 FAS 18676874 1967455 This study examined a potential role of paxillin in the feedback mechanism of [Rac] *regulation* by in OxPAPC stimulated ECs . Regulation RAC3 S1PR3 12069818 955567 Consistent with this , Edg1 and , and Edg5 *regulate* the activity of the Rho family GTPase [Rac] positively and negatively , respectively . Regulation RAC3 TNF 23639811 2805083 Cumulatively , these results demonstrate that NOX2 and its activator subunits ( p47phox and [Rac] ) *control* the secretion of by the liver following I/R. Interestingly , in the absence of Kupffer cells and NOX2 , NOX1 played a dominant role in TNF-a production following hepatic I/R . Regulation RAF1 EPHB2 11971957 933712 Using RafS259 mutants we also demonstrate that [Raf-1] is the sole *target* for PKA inhibition of and ERK induced gene expression , and that Raf-1 inhibition is mediated mainly through serine 259 phosphorylation . Regulation RAF1 EPHB2 19026988 2017160 Subsequently , the oridonin induced autophagy was also suppressed by [Raf-1] or JNK inhibition accompanied by the increase of apoptosis , but it was not *affected* by or p38 inhibition . Regulation RAG1 FOXO1 24614102 2930039 Specifically , CDK4 phosphorylated and inactivated FOXO1 , which prevented *dependent* induction of [Rag1] and Rag2 transcription . Regulation RAG2 FOXO1 24614102 2930040 Specifically , CDK4 phosphorylated and inactivated FOXO1 , which prevented *dependent* induction of Rag1 and [Rag2] transcription . Regulation RAI1 IL1B 16959849 1639688 The decrease in [retinoic acid induced] renin promoter activity in *response* to was blocked with the general tyrosine kinase inhibitor Genistein . Regulation RAI1 TGM2 11350930 814743 *Role* of in [retinoic acid induced] activation of RhoA associated kinase-2 . Regulation RAI14 IL1B 16959849 1639687 The decrease in [retinoic acid induced] renin promoter activity in *response* to was blocked with the general tyrosine kinase inhibitor Genistein . Regulation RAI14 TGM2 11350930 814742 *Role* of in [retinoic acid induced] activation of RhoA associated kinase-2 . Regulation RAI2 IL1B 16959849 1639689 The decrease in [retinoic acid induced] renin promoter activity in *response* to was blocked with the general tyrosine kinase inhibitor Genistein . Regulation RAI2 TGM2 11350930 814744 *Role* of in [retinoic acid induced] activation of RhoA associated kinase-2 . Regulation RALA FOXO1 23770673 2820251 The small GTPase [RALA] *controls* c-Jun N-terminal kinase mediated activation by regulation of a JIP1 scaffold complex . Regulation RANBP2 IFI27 12490316 1033155 To clarify the *roles* of and c-myc in [nasopharyngeal carcinoma (NPC)] , we used immunohistochemical studies to examine the expression of p27 and c-myc proteins in 69 patients with NPC . Regulation RANBP2 STK39 18083840 1837962 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation RANGAP1 STK39 18083840 1837977 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation RAP1A ITGAL 11165259 782772 These results suggest that CD98 cross linking activates LFA-1 via the PI3K signaling pathway and induces accumulation of [Rap1GTP] in a *dependent* manner , which in turn mediates the cytoskeleton dependent cell adhesion process . Regulation RARB CISH 7998926 283315 Differential *effects* of <9-cis> and all-trans retinoic acid on the induction of [retinoic acid receptor-beta] and cellular retinoic acid binding protein II in human neuroblastoma cells . Regulation RARB ESR1 12943740 1133789 We further determined that this *effect* of on [RARbeta] induction required the N-terminal AF-1 containing region , including the DNA binding domain , but was independent of the C-terminal ligand binding domain . Regulation RARB HACE1 19350571 2081061 Mutation of the putative catalytic cysteine ( C876 of LF HACE1 ) , which is indispensable for its E3 ubiquitin ligase activity , does not alter the repressive *effect* of on the transcriptional activity of [RARbeta] ( 3 ) . Regulation RARB HDAC1 11488527 845243 Antineoplastic action of 5-aza-2'-deoxycytidine and inhibitor and their *effect* on the expression of [retinoic acid receptor beta] and estrogen receptor alpha genes in breast carcinoma cells . Regulation RARB HDAC1 12392082 1007642 Treatment with the histone deacetvlase inhibitor trichostatin A (TSA) increased both basal and RA-induced betaRARE activity in DLD-1 , indicating that is *involved* in the regulation of [RARbeta] gene expression . Regulation RARB HDAC10 11488527 845241 Antineoplastic action of 5-aza-2'-deoxycytidine and inhibitor and their *effect* on the expression of [retinoic acid receptor beta] and estrogen receptor alpha genes in breast carcinoma cells . Regulation RARB HDAC10 12392082 1007640 Treatment with the histone deacetvlase inhibitor trichostatin A (TSA) increased both basal and RA-induced betaRARE activity in DLD-1 , indicating that is *involved* in the regulation of [RARbeta] gene expression . Regulation RARB HDAC11 11488527 845242 Antineoplastic action of 5-aza-2'-deoxycytidine and inhibitor and their *effect* on the expression of [retinoic acid receptor beta] and estrogen receptor alpha genes in breast carcinoma cells . Regulation RARB HDAC11 12392082 1007641 Treatment with the histone deacetvlase inhibitor trichostatin A (TSA) increased both basal and RA-induced betaRARE activity in DLD-1 , indicating that is *involved* in the regulation of [RARbeta] gene expression . Regulation RARB HDAC2 11488527 845244 Antineoplastic action of 5-aza-2'-deoxycytidine and inhibitor and their *effect* on the expression of [retinoic acid receptor beta] and estrogen receptor alpha genes in breast carcinoma cells . Regulation RARB HDAC2 12392082 1007643 Treatment with the histone deacetvlase inhibitor trichostatin A (TSA) increased both basal and RA-induced betaRARE activity in DLD-1 , indicating that is *involved* in the regulation of [RARbeta] gene expression . Regulation RARB HDAC3 11488527 845245 Antineoplastic action of 5-aza-2'-deoxycytidine and inhibitor and their *effect* on the expression of [retinoic acid receptor beta] and estrogen receptor alpha genes in breast carcinoma cells . Regulation RARB HDAC3 12392082 1007644 Treatment with the histone deacetvlase inhibitor trichostatin A (TSA) increased both basal and RA-induced betaRARE activity in DLD-1 , indicating that is *involved* in the regulation of [RARbeta] gene expression . Regulation RARB HDAC4 11488527 845236 Antineoplastic action of 5-aza-2'-deoxycytidine and inhibitor and their *effect* on the expression of [retinoic acid receptor beta] and estrogen receptor alpha genes in breast carcinoma cells . Regulation RARB HDAC4 12392082 1007635 Treatment with the histone deacetvlase inhibitor trichostatin A (TSA) increased both basal and RA-induced betaRARE activity in DLD-1 , indicating that is *involved* in the regulation of [RARbeta] gene expression . Regulation RARB HDAC5 11488527 845240 Antineoplastic action of 5-aza-2'-deoxycytidine and inhibitor and their *effect* on the expression of [retinoic acid receptor beta] and estrogen receptor alpha genes in breast carcinoma cells . Regulation RARB HDAC5 12392082 1007639 Treatment with the histone deacetvlase inhibitor trichostatin A (TSA) increased both basal and RA-induced betaRARE activity in DLD-1 , indicating that is *involved* in the regulation of [RARbeta] gene expression . Regulation RARB HDAC6 11488527 845237 Antineoplastic action of 5-aza-2'-deoxycytidine and inhibitor and their *effect* on the expression of [retinoic acid receptor beta] and estrogen receptor alpha genes in breast carcinoma cells . Regulation RARB HDAC6 12392082 1007636 Treatment with the histone deacetvlase inhibitor trichostatin A (TSA) increased both basal and RA-induced betaRARE activity in DLD-1 , indicating that is *involved* in the regulation of [RARbeta] gene expression . Regulation RARB HDAC7 11488527 845239 Antineoplastic action of 5-aza-2'-deoxycytidine and inhibitor and their *effect* on the expression of [retinoic acid receptor beta] and estrogen receptor alpha genes in breast carcinoma cells . Regulation RARB HDAC7 12392082 1007638 Treatment with the histone deacetvlase inhibitor trichostatin A (TSA) increased both basal and RA-induced betaRARE activity in DLD-1 , indicating that is *involved* in the regulation of [RARbeta] gene expression . Regulation RARB HDAC8 11488527 845235 Antineoplastic action of 5-aza-2'-deoxycytidine and inhibitor and their *effect* on the expression of [retinoic acid receptor beta] and estrogen receptor alpha genes in breast carcinoma cells . Regulation RARB HDAC8 12392082 1007634 Treatment with the histone deacetvlase inhibitor trichostatin A (TSA) increased both basal and RA-induced betaRARE activity in DLD-1 , indicating that is *involved* in the regulation of [RARbeta] gene expression . Regulation RARB HDAC9 11488527 845238 Antineoplastic action of 5-aza-2'-deoxycytidine and inhibitor and their *effect* on the expression of [retinoic acid receptor beta] and estrogen receptor alpha genes in breast carcinoma cells . Regulation RARB HDAC9 12392082 1007637 Treatment with the histone deacetvlase inhibitor trichostatin A (TSA) increased both basal and RA-induced betaRARE activity in DLD-1 , indicating that is *involved* in the regulation of [RARbeta] gene expression . Regulation RARB IFNG 10863413 580421 *Effects* of all-trans retinoic acid and on expression of [RAR beta] gene in Tca8113 cells . Regulation RARB IGFBP3 16760641 1590435 gene expression by 9cRA is mediated by a distinct DR-8 RARE located in the proximal region of the IGFBP promoter and *involves* the [RAR-beta] , a putative tumor suppressor in NSCLC . Regulation RARB MAPK1 16170358 1507543 More importantly , we demonstrate that the induction of PC12 growth inhibition by Nerve Growth Factor is indeed dependent upon [RAR beta2] transcriptional activation in a beta-arrestin 2- and *dependent* manner . Regulation RARB NCL 22693611 2615580 Our data indicate that *plays* a coregulatory role in transcriptional regulation of the tumor suppressor [RARB2] by COUP-TFII . Regulation RARB NR2F2 22693611 2615581 Our data indicate that nucleolin plays a coregulatory role in transcriptional *regulation* of the tumor suppressor [RARB2] by . Regulation RARB PPARG 18075297 1839979 PPARgamma specific inhibitor T007 and silencing of PPARgamma by siRNA diminished CDDO induced maturation and RARbeta2 mRNA along with PPARgamma induction indicating that activation is at least partially *responsible* for the [RARbeta2] transcription and maturation induction . Regulation RARB RARA 16261163 1525711 In response to RA , [RARbeta2] transcription is epigenetically *regulated* by . Regulation RARB RARA 16287870 1481164 Normally , *regulates* [RARbeta2] transcription by mediating dynamic changes of RARbeta2 chromatin in the presence and absence of RA . Regulation RARB RARA 7908827 241781 Induction of the HOXD4 promoter-enhancer in the presence of a selective RAR alpha antagonist indicated that the *dependent* [RAR beta] activation is nevertheless a necessary step in HOX gene activation . Regulation RARB RARA 9108446 424726 High-level expression of the [retinoic acid receptor beta] gene in normal cells of the uterine cervix is *regulated* by the and is abnormally down-regulated in cervical carcinoma cells . Regulation RARB RARG 9113387 426015 These results suggested that the inhibitory effect of RA on the mineralization of human osteoblasts is mediated by the activation of RAR alpha and/or [RAR beta] and that preferentially *regulates* the expression of osteocalcin without influence on mineralization . Regulation RARB RARG 9774664 540021 ( RARgamma1 ) levels *control* [RARbeta2] expression in SK-N-BE2 ( c ) neuroblastoma cells and regulate a differentiation-apoptosis switch . Regulation RARB RARS 15189119 1256678 We then focus on a discussion of RARalpha and acute promyelocytic leukemia followed by a discussion of the *role* of , in particular [RARbeta] expression , in other cancer types . Regulation RARB TGFB1 7556459 327697 alone had no *effect* on [RAR-beta] mRNA expression . Regulation RARG RARB 9113387 426017 These results suggested that the inhibitory effect of RA on the mineralization of human osteoblasts is mediated by the activation of RAR alpha and/or and that [RAR gamma] preferentially *regulates* the expression of osteocalcin without influence on mineralization . Regulation RARG RARB 9774664 540022 [Retinoic acid receptor gamma1] ( RARgamma1 ) levels *control* expression in SK-N-BE2 ( c ) neuroblastoma cells and regulate a differentiation-apoptosis switch . Regulation RARRES3 TGM2 17762858 1858224 [Tazarotene induced gene 3 (TIG3)] *regulates* keratinocyte terminal differentiation by activating type I ( TG1 ) . Regulation RASA3 INS 10869341 722327 Thus , the Ins ( 1,3,4,5 ) P ( 4 ) -binding PH domain from GAP1(IP4BP) defines a novel class of group I PH domains that constitutively targets the protein to the plasma membrane and may allow [GAP1(IP4BP)] to be *regulated* in vivo by ( 1,3,4,5 ) P ( 4 ) rather than PtdIns ( 3,4,5 ) P ( 3 ) . Regulation RASD1 INS 22700767 2633815 The regulation of [Rasd1] expression by glucocorticoids and prolactin *controls* peripartum maternal secretion . Regulation RASGRP1 DGKI 15894621 1411641 *regulates* [Ras guanyl releasing protein] 3 and inhibits Rap1 signaling . Regulation RASGRP3 DGKI 15894621 1411658 Because Rap1 can antagonize the function of Ras , our data are consistent with a model in which *regulates* [RasGRP3] with a predominant effect on Rap1 activity . Regulation RASIP1 IL1B 12010575 941242 In conclusion , human articular chondrocytes produce [sIL-1Ra in] *response* to and IL-6 . Regulation RASSF1 FAS 19062280 2001796 NDR kinase is activated by [RASSF1A/MST1] in *response* to receptor stimulation and promotes apoptosis . Regulation RB1 CCND1 10376532 623429 The phosphorylation of [pRb] is *regulated* positively by and negatively by CDK inhibitors , such as p16 ( CDKN2/MTS-1/INK4A ) . Regulation RB1 CCND1 7739541 305738 These data provide evidence for an upstream control function of , and a downstream *role* for [pRB] , in the order of events regulating transition through late G1 phase of the mammalian cell division cycle . Regulation RB1 CCND1 8704183 373371 To examine the *effect* of overexpression on [pRB] in primary tumor tissue , we studied pRB expression in low-grade B-cell neoplasms , with particular regard to mantle cell lymphoma , which is characterized by cyclin D1 (bcl-1) overexpression . Regulation RB1 EPHB2 15547725 1338352 Our data indicate that activated *plays* an important role in cyclin D1 and Cdk-2 expression and phosphorylation of [pRB] at Ser780 and Ser795 in liver cancer cells . Regulation RB1 TNFSF10 19229287 2105913 The results also showed that B. resulted in selective location in tumors and exhibited a definite antitumor *effect* on S180 [osteosarcoma] . Regulation RBL1 MAP2K6 12242027 989722 Inhibition of did not *affect* the increase in [p107] expression in stimulated cells indicating that induction of p107 is independent of MAP kinase signaling . Regulation RBL2 SNCAIP 15213242 1262479 To analyze the involvement in allergic reactions of platelets and sphingosine 1-phosphate (Sph-1-P) , a lysophospholipid mediator released from activated platelets , the *effects* of and a supernatant prepared from activated platelets on mast cell line [RBL-2H3] were examined . Regulation RBM10 FAS 24530524 2924341 It has been reported that [RBM10] constitutes spliceosome complexes and that RBM5 , a close homologue of RBM10 , *regulates* alternative splicing of apoptosis related genes , and cFLIP . Regulation RCAN1 DYRK1A 21965663 2507432 *Regulation* of [RCAN1] protein activity by protein mediated phosphorylation . Regulation RCAN1 EGR1 19124655 2025082 Biochemical and genetic evidence suggested that *controls* [Rcan1] expression . Regulation RCAN1 GATA2 15448146 1334965 VEGF- and thrombin mediated induction of [DSCR-1] *involves* the cooperative binding of NF-ATc and to neighboring consensus motifs in the upstream promoter . Regulation RCAN1 GATA3 15448146 1334966 VEGF- and thrombin mediated induction of [DSCR-1] *involves* the cooperative binding of NF-ATc and to neighboring consensus motifs in the upstream promoter . Regulation RCAN1 GSK3B 16649988 1557392 While RCAN1s can regulate calcineurin and GSK-3beta , it has also been shown that calcineurin and can *regulate* [RCAN1s] . Regulation RCAN1 KDR 20625401 2291758 Our data suggests that RCAN1 .4 expression is induced by activation in a Ca ( 2+ ) and PKC-delta dependent manner and that [RCAN1] .4 *acts* to regulate calcineurin activity and gene expression facilitating endothelial cell migration and tubular morphogenesis . Regulation RCAN1 MYOZ2 22987565 2716190 Likewise , lentiviral mediated expression of the ( I246M ) did not *affect* [RCAN1] .4 and calcineurin ( PPP3CB ) protein levels . Regulation RCAN1 NFATC1 15448146 1334967 VEGF- and thrombin mediated induction of [DSCR-1] *involves* the cooperative binding of and GATA-2/3 to neighboring consensus motifs in the upstream promoter . Regulation RCAN1 NFATC2 23028325 2679597 We found that K15 directly recruits PLC?1 , and thereby activates *dependent* [RCAN1] expression which results in the formation of angiogenic tubes . Regulation RCAN1 PPP3CA 11110780 757420 In the present study , we show that expression of [MCIP1] is *regulated* by activity in hearts of mice with cardiac hypertrophy , as well as in cultured skeletal myotubes . Regulation RCAN1 PPP3CA 15975916 1440993 These findings suggest that *dependent* induction of [DSCR1] .4 product may represent an important auto-regulatory mechanism for the homeostatic control of NFAT signaling in neural cells . Regulation RCAN1 PPP3CA 16649988 1557393 While RCAN1s can regulate calcineurin and GSK-3beta , it has also been shown that and GSK-3beta can *regulate* [RCAN1s] . Regulation RCAN1 PPP3CA 18293408 1891593 Finally , we report that *dependent* expression of Cox-2 and [Rcan 1-4] is induced by physiological calcium mobilizing agents , such as thrombin , agonists of purinergic and glutamate receptors , and L-type voltage gated calcium channels . Regulation RCAN1 PPP3CA 19136967 2032053 The calcium activated protein phosphatase is *controlled* by [regulator of calcineurin (RCAN)] in organisms ranging from yeast to mammals . Regulation RCAN1 PPP3CA 23028325 2679598 We found that K15 directly recruits PLC?1 , and thereby activates *dependent* [RCAN1] expression which results in the formation of angiogenic tubes . Regulation RCAN1 PPP3CA 24155299 2859809 [Regulator of calcineurin 1 (RCAN1)] *controls* the activity of calcium/calmodulin dependent phosphatase , which has been implicated in human anxiety disorders . Regulation RCAN1 PPP3CB 15975916 1440994 These findings suggest that *dependent* induction of [DSCR1] .4 product may represent an important auto-regulatory mechanism for the homeostatic control of NFAT signaling in neural cells . Regulation RCAN1 PPP3CB 18293408 1891594 Finally , we report that *dependent* expression of Cox-2 and [Rcan 1-4] is induced by physiological calcium mobilizing agents , such as thrombin , agonists of purinergic and glutamate receptors , and L-type voltage gated calcium channels . Regulation RCAN1 PPP3CB 19136967 2032054 The calcium activated protein phosphatase is *controlled* by [regulator of calcineurin (RCAN)] in organisms ranging from yeast to mammals . Regulation RCAN1 PPP3CB 23028325 2679599 We found that K15 directly recruits PLC?1 , and thereby activates *dependent* [RCAN1] expression which results in the formation of angiogenic tubes . Regulation RCAN1 PPP3CB 24155299 2859810 [Regulator of calcineurin 1 (RCAN1)] *controls* the activity of calcium/calmodulin dependent phosphatase , which has been implicated in human anxiety disorders . Regulation RCAN1 PPP3CC 15975916 1440995 These findings suggest that *dependent* induction of [DSCR1] .4 product may represent an important auto-regulatory mechanism for the homeostatic control of NFAT signaling in neural cells . Regulation RCAN1 PPP3CC 18293408 1891595 Finally , we report that *dependent* expression of Cox-2 and [Rcan 1-4] is induced by physiological calcium mobilizing agents , such as thrombin , agonists of purinergic and glutamate receptors , and L-type voltage gated calcium channels . Regulation RCAN1 PPP3CC 19136967 2032055 The calcium activated protein phosphatase is *controlled* by [regulator of calcineurin (RCAN)] in organisms ranging from yeast to mammals . Regulation RCAN1 PPP3CC 23028325 2679600 We found that K15 directly recruits PLC?1 , and thereby activates *dependent* [RCAN1] expression which results in the formation of angiogenic tubes . Regulation RCAN1 PPP3CC 24155299 2859811 [Regulator of calcineurin 1 (RCAN1)] *controls* the activity of calcium/calmodulin dependent phosphatase , which has been implicated in human anxiety disorders . Regulation RCAN1 PPP3R1 11110780 757421 In the present study , we show that expression of [MCIP1] is *regulated* by activity in hearts of mice with cardiac hypertrophy , as well as in cultured skeletal myotubes . Regulation RCAN1 PPP3R1 16649988 1557394 While RCAN1s can regulate calcineurin and GSK-3beta , it has also been shown that and GSK-3beta can *regulate* [RCAN1s] . Regulation RCAN1 STAT2 22426484 2577617 Decreases in RCAN1 were blocked by a proteasome inhibitor , indicating that *regulates* [RCAN1] degradation via the ubiquitin-proteasome system . Regulation RCAN1 TNF 15358155 1293360 We show in this study that [DSCR1] is greatly induced in endothelial cells in *response* to VEGF , , and A23187 treatment , and that this up-regulation is inhibited by inhibitors of the calcineurin-NFAT ( nuclear factor of activated T cells ) signaling pathway as well as by PKC inhibition and a Ca ( 2+ ) chelator . Regulation RCAN1 VEGFA 15358155 1293361 We show in this study that [DSCR1] is greatly induced in endothelial cells in *response* to , TNF-alpha , and A23187 treatment , and that this up-regulation is inhibited by inhibitors of the calcineurin-NFAT ( nuclear factor of activated T cells ) signaling pathway as well as by PKC inhibition and a Ca ( 2+ ) chelator . Regulation RCAN1 VEGFA 23028325 2679592 During physiological angiogenesis , expression of [RCAN1] in endothelial cells is *regulated* by ( vascular endothelial growth factor ) through a pathway involving the activation of PLC?1 , Calcineurin and NFAT1 . Regulation RCC2 STK39 18083840 1837797 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation RCN1 TNF 18561328 1940789 Novel surface expression of [reticulocalbin 1] on bone endothelial cells and human prostate cancer cells is *regulated* by . Regulation RECK MAP2K6 21167264 2390776 *Effects* of DNMT and inhibitors on the expression of [RECK] , MMP-9 , -2 , uPA and VEGF in response to arsenite stimulation in human uroepithelial cells . Regulation REG1A TLR7 19843574 2187462 Although signaling through certain TLRs is known to modulate the function of T lymphocytes , the *effect* of stimulation on CD4 ( + ) CD25 ( + ) T ( [reg] ) cell activity has not yet been elucidated . Regulation REG1A TNF 21483233 2562075 The underlying molecular mechanism by which *regulates* hepatic [protein-tyrosine phosphatase (PTP)-1B] expression is not well understood . Regulation REL CD14 10996025 733684 In the present study , we investigated the *role* of and complement receptor type 3 (CR3) in mediating NO production and [NF-kappaB/Rel] activation induced by angelan and LPS . Regulation REL RORC 21940679 2497483 Consistent with this finding , [c-Rel] was activated in response to TCR signaling in the early stages of Th17 development and *controlled* the expression of , which encodes the Th17 transcription factor retinoic acid related orphan receptor ?t . Regulation RELA ADRB2 19167076 2043523 *regulate* Toll-like receptor 4-induced late-phase [NF-kappaB] activation . Regulation RELA ALOX5 18498541 1917579 We then investigated whether these drugs affect [NF-kappaB] and AP-1 activities in A549 lung epithelial cells , and whether this potential regulation *involves* H1-receptor and <5-LO> . Regulation RELA ARSA 16116334 1449084 This study investigated the *effect* of on the late phase of ischemic preconditioning ( PC ) against myocardial infarction and on the activation of [NF-kappaB] in the preconditioned myocardium . Regulation RELA ARSA 17644113 1865901 The aim of this study was to investigate the *effect* of DC and on [NF-kappaB] signaling , and determine its role in programmed cell death in a human gastric carcinoma cell line . Regulation RELA ARSA 18174252 1875684 We studied in several human colon ( HT-29 , HCT-15 , LoVo , HCT116 and SW-480 ) , pancreatic ( BxPC-3 , MIA PaCa-2 ) and breast ( MDA-MB-231 and MCF-7 ) cancer cell lines , the *effect* of on [NF-kappaB] activation , determined by electrophoretic mobility shift assays , immunofluorescence and western blot analyses of nuclear proteins . Regulation RELA ARSA 18174252 1875688 The *effect* of on [NF-kappaB] binding to DNA was significantly correlated with its effect on cell growth ( P < 0.05 ) indicating that the growth inhibitory effect of NO-ASA may be mediated by its effect on NF-kappaB . Regulation RELA CAPN8 14686903 1179550 Our data indicate that the Ca2+ dependent protease is *involved* in the [NF-kappaB] activation in neurons in response to N-methyl-d-aspartate receptor occupancy by glutamate . Regulation RELA CAPN8 15688415 1382547 NF-kappaB , a regulator of Bcl-2 expression , and protease activity , a *regulator* of [NF-kappaB] , were both inhibited by RES . Regulation RELA CCND1 15652748 1364335 Mechanistically , the effects of Vav1 require its GEF activity and the activation of Rac1 , PAK1 , and [NF-kappaB] and *involve* upregulation . Regulation RELA CCND1 17008396 1674086 To further understand the mechanism of TNF stimulated growth of primary MEC , the requirement for [NFkappaB1/p50] , and the *role* of in TNF stimulated growth were examined . Regulation RELA CCND1 17944672 1814244 Furthermore , L-685,458 down-regulated , B-cell lymphocytic-leukemia proto-oncogene 2 and c-Myc expressions , which are *regulated* by the transcription factor [NF-kappaB] . Regulation RELA CD14 10996025 733686 In the present study , we investigated the *role* of and complement receptor type 3 (CR3) in mediating NO production and [NF-kappaB/Rel] activation induced by angelan and LPS . Regulation RELA CD14 11546774 882134 In conclusion , H. pylori induced [NF-kappaB] activation in epithelial cells is dependent on cag PAI and contact but does not *involve* and IRAK , whereas in macrophage/monocytic cells it is independent of cag PAI or contact but involves CD14 and TLR4 . Regulation RELA CD14 11779220 900063 *dependent* activation of [NF-kappaB] by filarial parasitic sheath proteins . Regulation RELA CD14 11779220 900070 These observations suggest that the capacity of certain lung epithelial cells to interact with microfilarial antigens , activate [NF-kappaB] in a *dependent* manner and produce pro-inflammatory cytokines may be a contributory factor to immune responses manifested by tropical pulmonary eosinophilia . Regulation RELA CD14 12595465 1061560 The LPS receptor complex utilized by the bladder epithelial cell lines included and Toll-like receptors , and signaling *involved* the activation of [NF-kappaB] and p38 mitogen activated protein kinase . Regulation RELA CD14 16879219 1593893 These findings suggest that LPS induced decreased PS expression in hepatocytes and SECs is mediated by MEK/ERK signaling and [NFkappaB] activation and that membrane bound and TLR-4 are *involved* in this mechanism . Regulation RELA CD14 19840871 2203174 *played* a significant role in the activation of [NF-kappaB] in response to necrotic cells in the presence or absence of TLR2 . Regulation RELA CD14 7876168 298439 The combination of plasma membrane enriched fraction and cytosol was sufficient to activate [NF-kappa B] in a *dependent* manner only in the presence of ATP as judged by the binding of NF-kappa B to the IL-8 gene kappa B site on an electrophoretic mobility shift assay . Regulation RELA CD14 9574560 502566 This study was undertaken to evaluate the *role* of and complement receptors type 3 (CR3) and 4 ( CR4 ) in mediating TNF release and [NF-kappaB] activation induced by LPS and cell wall preparations from group B streptococci type III ( GBS ) . Regulation RELA CTNNAL1 17952117 1889015 , a Rho signalling component , can *regulate* [NF-kappaB] through binding to IKK-beta , and confers resistance to apoptosis . Regulation RELA DAPK1 18292548 1872964 In contrast , IL-1beta- and TNF-alpha triggered [NF-kappaB] activation was not *affected* by . Regulation RELA EDN2 11692473 876502 The subsequent [NF-kappa B] activation probably *involves* participation of signaling and , perhaps , NF-AT3 activation . Regulation RELA EPHB2 11108246 756762 However , TNFalpha induced [NF-kappaB] DNA binding activity is *independent* of p38MAPK and activation . Regulation RELA EPHB2 11773061 916290 Moreover , the NF-kappa B promoter activity decreased with overexpression of dominant negative ERK expression constructs , and EMSA analyses further support the hypothesis that acts upstream of NF-kappa B and *regulates* the [NF-kappa B] DNA binding activity . Regulation RELA EPHB2 12055070 951585 Furthermore , AP-1 and [NF-kappaB] DNA binding was not *affected* by and p38 inhibition . Regulation RELA EPHB2 12068083 955375 PD98059 did not inhibit NF-kappaB binding , demonstrating that was not *responsible* for [NF-kappaB] activation . Regulation RELA EPHB2 12677169 1076929 We demonstrate , for the first time , that glycated albumin activates RAW cell ERK and promotes *dependent* increases in TGF-beta(1) production , oxidative stress , and [NF-kappa B] activation . Regulation RELA EPHB2 15100369 1239797 mRNA expression of MCP-1 was abolished by [NF-kappaB] inhibition , but were not *affected* by the inhibition of , JNK , or p38 . Regulation RELA EPHB2 15147892 1248164 HHE increased the activity of p38 MAPK and extracellular signal regulated kinase ( ERK ) , but not c-jun NH ( 2 ) -terminal kinase , indicating that p38 MAPK and are closely *involved* in HHE induced [NF-kappaB] transactivation . Regulation RELA EPHB2 15670752 1365880 Specifically , TPA induced nuclear translocation of NF-kappaB was effectively attenuated by GF109203X and PD98059 , suggesting PKC and *regulation* of [NF-kappaB] nuclear localization in response to TPA . Regulation RELA EPHB2 16169610 1525421 Activation of [NF-kappaB] was *independent* of and p38 MAP kinase . Regulation RELA EPHB2 16326421 1488359 Together these results suggest that while gamma-IR and Ras both contribute to the upregulation of CD23 expression via NF-kappaB Raf or is not *involved* in gamma-IR induced [NF-kappaB] activation . Regulation RELA EPHB2 17312151 1699698 WT FcgammaRIIA and mutants that associated with lipid rafts efficiently activated [NF-kappaB] , in an *dependent* manner . Regulation RELA EPHB2 18335517 1925147 These data indicate that near-physiological concentrations of Mn potentiate cytokine induced expression of NOS2 and production of NO in astrocytes via activation of sGC , which promotes *dependent* enhancement of [NF-kappaB] signaling . Regulation RELA EPHB2 18442799 1900635 In this study , we show that and p38 MAP kinase are *involved* in the downregulation of cell surface TNF-R1 upon exposure to Ac-CHX and the subsequent inhibition of TNF-alpha induced [NF-kappaB] activation . Regulation RELA EPHB2 20537708 2279380 In conclusion , all these findings demonstrate a key *role* of and TLR4 in association with [NF-kappaB] in IL-10 modulation induced by T. cruzi and suggest that this regulatory effect involves parasite-DC interactions not described yet . Regulation RELA EPHB2 20558745 2302530 rHSP90alpha induced the activities of , PI3K/Akt , and NF-kappaB p65 , but only [NF-kappaB] activation was *involved* in HSP90alpha induced integrin alpha(V) expression . Regulation RELA FAS 11689460 876273 CD40 activation induced , *dependent* apoptosis and [NF-kappaB/AP-1] signaling in human intrahepatic biliary epithelial cells . Regulation RELA FAS 12883671 1116465 However , the *role* of in induction of [NF-kappaB] activation in HCC cells is not well understood . Regulation RELA FAS 16330535 1512012 costimulation of naive CD4 T cells is *controlled* by [NF-kappaB] signaling and caspase activity . Regulation RELA FUT4 17410536 1736266 In an attempt to identify an effective therapeutic agent for pancreatic cancer , the authors studied the *role* of , a synthetic serine protease inhibitor , in the inhibition of [NF-kappaB] activation and the induction of apoptotic responses . Regulation RELA FUT4 17410536 1736288 To examine the *effect* of on the inhibition of [NF-kappaB] and the induction of apoptosis in pancreatic cancer cell lines , Western and Northern blot analyses , electromobility shift ( EMSA ) , luciferase reporter gene , DNA fragmentation , immunoprecipitation , in vitro kinase , small interfering RNA ( siRNA ) , and chromatin immunoprecipitation ( ChIP ) assays were performed . Regulation RELA HES2 20689135 2299307 The infusion of HES130/0.4 in endotoxemic rats , especially 15 ml/kg , significantly reduced the release of plasma TNF-alpha and IL-1beta , which was consistent with the observed inhibitory *effects* of on [NF-kappaB] activation , TLR4 mRNA expression , and TLR4 protein level in monocytes . Regulation RELA IL1B 10336492 615487 The activation of [NF-kappaB] and the subsequent cytokine induced neutrophil chemoattractant induction in *response* to were inhibited by proteasome inhibitors , MG132 and proteasome inhibitor I. Translocation of NF-kappaB into nuclei occurs by the phosphorylation , multi-ubiquitination , and degradation of IkappaBalpha , a regulatory protein of NF-kappaB . Regulation RELA IL1B 10336492 615491 These results indicate that the transient translocation of [NF-kappaB] in *response* to may be partly dependent on transient proteasome activation . Regulation RELA IL1B 10490923 645820 [NF-kappaB] activation in *response* to TNF-alpha , , phorbol ester , and H ( 2 ) O ( 2 ) was down-regulated by polaprezinc . Regulation RELA IL1B 10594073 573028 An essential *role* of in mediating [NF-kappaB] activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia . Regulation RELA IL1B 10605929 655656 Interestingly , transfection of epithelial cells with the 5-LOX and 5-LOX activating protein expression vectors restored ROI production and ROI dependent [NF-kappaB] activation in *response* to . Regulation RELA IL1B 10629862 576468 We also found in IL-1 beta induced CINC expression using cultured C6 glioma cells , the transient translocation of [NF-kappa B] in *response* to is partly dependent on transient proteasome activation . Regulation RELA IL1B 10638662 660336 Genistein , a nonspecific tyrosine kinase inhibitor , also had no effect on mediated *effects* on [NF-kappaB] . Regulation RELA IL1B 10644648 661130 These data suggest that constitutive [NF-kappaB] p65 protein synthesis is *regulated* by , particularly during pregnancy . Regulation RELA IL1B 10657679 664247 However , when the *dependent* induction of [NF-kappa B] was inhibited , the antiapoptotic effect of IL-1 beta was partially reversed , suggesting that NF-kappa B-mediated gene activation is part of the protective mechanism . Regulation RELA IL1B 10766857 684576 We conclude that cellular differentiation of HT-29 cells selectively impairs the IL-1beta signaling pathway inhibiting both [NF-kappaB] and JNK activity in *response* to . Regulation RELA IL1B 10882729 730452 Neither receptor alone was able to mediate transcriptional activation of [NF-kappaB] in *response* to IL-1alpha , , or IL-18 . Regulation RELA IL1B 10942208 721297 Since pro-inflammatory cytokine IL-1beta has been shown to induce prostaglandin E2 ( PGE2 ) release in human gingival fibroblasts (HGF) , here we analyzed the *effect* of on the expression of COX-2 and the activation of [NFkappaB] in HGF . Regulation RELA IL1B 11104703 756493 However , pretreatment with the proteasome inhibitor MG132 under conditions that prevented the *dependent* activation of the nuclear factor [NF-kappaB] also blocked the inhibitory effect of IL-1beta on IL-6 activated STAT1 . Regulation RELA IL1B 11153595 761129 The effect of the antioxidant compound , N-acetyl-L-cysteine (NAC) , on release and *regulation* of [NF-kappaB] in a human myelo-monocytic cell line ( THP-1 ) differentiated into macrophages was studied . Regulation RELA IL1B 11445585 860066 Furthermore , lambda/iotaPKC and cPLA(2) phosphorylation was attenuated by phosphatidyinositol 3-kinase ( PI3-kinase ) inhibitors , which also reduced [NF-kappaB] activation in *response* to TNF-alpha and , indicating a role for PI3-kinase in these processes in human keratinocytes . Regulation RELA IL1B 11976320 954000 CaMKKc and Akt overexpression decreases IRAK1 mediated [NF-kappaB] activity and its association with MyD88 in *response* to stimulation . Regulation RELA IL1B 12588520 1059444 Activation of [NF kappa B] in *response* to was no longer apparent in IL-1RI knockout mice , confirming that this receptor is essential for the transduction of IL-1 signal in the pituitary , but remained after LPS treatment . Regulation RELA IL1B 12670873 1080138 This leads to sustained suppression of induced [NF-kappaB] transcriptional *regulation* of proinflammatory genes . Regulation RELA IL1B 12860389 1111472 *dependent* activation of [NF-kappaB] mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase . Regulation RELA IL1B 12934647 1132848 Salicylate inhibited the and TNF-alpha induced COX-2 expressions , *regulated* the activation of ERK , IKK and IkappaB degradation , and the subsequent activation of [NF-kappaB] , in neonatal rat ventricular cardiomyocytes . Regulation RELA IL1B 14985981 1236680 The *effects* of on the pump and [NF-kappaB] were prevented by the COX inhibitor indomethacin . Regulation RELA IL1B 15240151 1270132 Specifically , IL-1beta induced nuclear translocation of NF-kappaB was in part attenuated by LY294002 , but not by GF109203X , SB203580 , and SP600125 , suggesting PI3K dependent nuclear translocation of [NF-kappaB] in *response* to . Regulation RELA IL1B 15604022 1346803 [NF-kappaB] *responses* to , CD40L , and LPS were donor dependent ( n=7 ) , correlated with the quality of iDC preparations ( p=0.002 ) , and IL-12 p70 production ( p=0.010 ) . Regulation RELA IL1B 15739117 1383024 To test this hypothesis , we compared the *effects* of , high glucose , and hydrogen peroxide , on [NFkappaB] DNA binding activity and target gene mRNA levels in cultured rat islets . Regulation RELA IL1B 16417227 1514519 Pseudomonas aeruginosa- and mediated induction of human beta-defensin-2 in keratinocytes is *controlled* by [NF-kappaB] and AP-1 . Regulation RELA IL1B 17136479 1747054 Investigation of mediated *regulation* of [NF-kappaB] activation in colonic cells reveals divergence between PKB and PDK transduced events . Regulation RELA IL1B 17337443 1726640 IRAK-4 KD cells are severely impaired in [NFkappaB] , JNK , and p38 activation in *response* to or TLR7 ligand . Regulation RELA IL1B 17645739 1793281 However , although Dex did not inhibit the nuclear translocation of p65 [NF-kappaB] in *response* to , it profoundly inhibited NF-kappaB promoter- and HBD-2 promoter-driven luciferase activities . Regulation RELA IL1B 17663801 1780462 In *response* to , or IL10 , the levels of phosphorylated [NF-kappaB] and STAT3 -- respectively -- increased significantly for all the studied cell types . Regulation RELA IL1B 18266467 1896065 Here we demonstrate that ectopic expression of B14 inhibited [NF-kappaB] activation in *response* to TNFalpha , , poly ( I:C ) , and PMA . Regulation RELA IL1B 18510099 1840594 IRAK-4 KD cells were severely impaired in [NF-kappaB] , JNK , and p38 activation in *response* to or TLR7 ligand . Regulation RELA IL1B 19669392 2186116 Determine the *effect* of and dynamic compression on [NFkappaB] activation and IkappaB-alpha gene expression in chondrocyte/agarose constructs . Regulation RELA IL1B 23570163 1506785 [NF-kappaB] *responses* to , CD40L , and LPS were donor dependent ( n = 7 ) , correlated with the quality of iDC preparations ( p = 0.002 ) , and IL-12 p70 production ( p = 0.010 ) . Regulation RELA ITGB2 11701612 878738 *dependent* activation of [NF-kappaB] was potentiated by wild-type , and attenuated by dominant negative , TRAF6- and TGF-beta activated kinase ( TAK1 ) constructs . Regulation RELA ITGB2 9062344 417869 *dependent* oxidative [NF-kappaB] activation leading to nitric oxide production in rat Kupffer cells cocultured with syngeneic hepatoma cells . Regulation RELA MAP2K6 10878013 722410 A constitutive active -- > ERK pathway negatively *regulates* [NF-kappa B-dependent] gene expression by modulating TATA binding protein phosphorylation . Regulation RELA MAP2K6 15688034 1376207 Inhibitors of phosphatidylinositol-3'-kinase and Src family kinases significantly inhibited HGF/SF mediated activation of NF-kappaB , while inhibitors of , protein kinase C , and p70 S6 kinase had a modest effect or no *effect* on [NF-kappaB] activity . Regulation RELA MAP2K6 16034135 1436470 Neither overexpression or inhibition of , Ras , or Akt *affected* HB-EGF mediated inhibition of [NF-kappaB] activation . Regulation RELA MAP2K6 9585425 505231 In contrast , inhibition of and PI3-kinase did not *affect* osteopontin induced [NF-kappaB] activation . Regulation RELA MIP 24360910 2905499 The goal of this study was to understand how p65/RelA co-regulated genes , specifically those of the cytokine and endocannabinoid systems , were affected in HD. p65/RelA levels were lower in human HD tissue and R6/2 HD mice , as were the levels of the type 1 cannabinoid receptor ( CB1 ) , IL-1ß , IL-8 , CCL5 , GM-CSF , , and TNFa , all of which may be *regulated* by [p65/RelA] . Regulation RELA NEDD9 13679070 1140269 Our findings suggest that is *involved* in Casper mediated regulation of apoptosis and [NF-kappaB] activation . Regulation RELA PECAM1 20173029 2215490 To confirm and extend these observations , we examined the *effect* of engaging , cross linking , or expressing on [NF-kappaB] activation in a variety of human cells . Regulation RELA PECAM1 20173029 2215494 had no *effect* on the phosphorylation of the [NF-kappaB] inhibitory protein , IkappaBalpha ; Regulation RELA PTGER2 20516073 2295232 Shear induced interleukin-6 synthesis in chondrocytes : *roles* of and EP3 in cAMP/protein kinase A- and PI3-K/Akt dependent [NF-kappaB] activation . Regulation RELA RCAN1 17062574 1654649 To elucidate the molecular basis of these anti-inflammatory effects , we analyzed the *role* of in the regulation of [NF-kappaB] transactivation using glioblastoma cells stably transfected with DSCR1 .4 or its truncation mutants ( DSCR1.4- ( 1-133 ) and DSCR1 .4- ( 134-197 ) ) . Regulation RELA S1PR3 11673450 888521 and Edg-5 , which are coupled to G ( i ) , G ( q ) , and G(13) , *affect* activation of [NF-kappa B] , whereas Edg-1 , which is coupled to G ( i ) alone , does not . Regulation RELA STK39 10485710 644490 Here we show that the Akt is *involved* in the activation of [NF-kappaB] by tumour necrosis factor (TNF) . Regulation RELA TGM2 18804908 2012324 It appears that increased expression of is *responsible* for the constitutive activation of [NF-kappaB] in cancer cells . Regulation RELA TGM2 18923241 1977481 The objective of the present study was to investigate the expression of TGase 2 in the human atherosclerotic human coronary artery , and the possible *roles* of in [NF-kappaB] activation . Regulation RELA TLR7 15571070 1344252 In response to challenge with microbes or microbial derived substances the activation and nuclear translocation of [NF-kappaB] , the production of nitric oxide ( NO ) and inflammatory cytokines occur in keratinocytes , in a *dependent* manner . Regulation RELA TLR7 16244651 1476924 Furthermore , epithelial cell-surface hyaluronan was protective against apoptosis , in part , through *dependent* basal activation of [NF-kappaB] . Regulation RELA TLR7 16894359 1601089 Lung epithelial cell overexpression of high molecular mass HA protected mice against acute lung injury and apoptosis , in part through *dependent* basal activation of [NF-kappaB] . Regulation RELA TLR7 17100624 1644761 In the intestine , *dependent* activation of [NF-kappaB] plays a vital role in maintaining epithelial homeostasis as well as regulating infections and inflammation , while dysregulation of TLR signaling is associated with the pathogenesis of inflammatory bowel diseases (IBD) . Regulation RELA TNF 10195897 604194 Mouse embryonic fibroblast cells that were isolated from IKK2-/- embryos showed a marked reduction in tumor necrosis factor-alpha (TNF-alpha)- and interleukin-1alpha induced [NF-kappaB] activity and an enhanced apoptosis in *response* to . Regulation RELA TNF 10367939 561451 In the present study , we have investigated the *effects* of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ) , interleukin-10 (IL-10) and -13 ( IL-13 ) , transforming growth factor-beta1 ( TGF-beta1 ) , granulocyte-macrophage colony stimulating factor ( GM-CSF ) , and on cell proliferation and induction of transcription factors AP-1 and [NF-kappaB] in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro . Regulation RELA TNF 10490923 645819 [NF-kappaB] activation in *response* to , IL-1beta , phorbol ester , and H ( 2 ) O ( 2 ) was down-regulated by polaprezinc . Regulation RELA TNF 10524940 653867 In normal human urothelial cells , activation of the [NF-kappaB] complex in *response* to stimulation with , LPS , and dsRNA was detected by immunohistochemical methods and EMSA . Regulation RELA TNF 10532402 562332 Peroxides , therefore , possibly play an important part in the redox-sensitive pathway of *dependent* [NF-kappaB] activation in canine skin . Regulation RELA TNF 10564845 567348 The system successfully simulated the molecular process steps underlying outcomes of eight different molecular genetics laboratory experiments , including those dealing with [NF-kappaB] and AP-1 regulation in immunodeficiency virus infection and *responses* . Regulation RELA TNF 10728675 678161 In the progenitor B lymphocyte model FL5.12 , whereas [NF-kappaB] has an antiapoptotic function in *response* to , cytokine withdrawal causes nuclear translocation of NF-kappaB/cRel , where it is apoptogenic . Regulation RELA TNF 10766741 684459 NEMO/IKKgamma-deficient primary murine embryonic fibroblasts ( MEFs ) lack detectable [NF-kappaB] DNA binding activity in *response* to , IL-1 , LPS , and Poly ( IC ) and do not show stimulus dependent IkappaB kinase activity , which correlates with a lack of phosphorylation and degradation of IkappaBalpha . Regulation RELA TNF 10766844 684552 The Drosophila receptor associated factor-1 ( DTRAF1 ) interacts with Pelle and *regulates* [NFkappaB] activity . Regulation RELA TNF 10849440 701177 TAF(II)105 , a substoichiometric coactivator subunit of TFIID , is important for activation of anti-apoptotic genes by [NF-kappaB] in *response* to the cytokine . Regulation RELA TNF 10940316 721035 [NFkappaB] activation in *response* to and bleomycin , the latter causing topoisomerase II-independent DNA damage , was intact in both cell lines . Regulation RELA TNF 10963848 727474 We also demonstrate that histaglobin inhibits the nuclear translocation of [NF-kappaB] in *response* to or lipopolysaccharide (LPS) in bone marrow derived macrophages of Balb/c mice . Regulation RELA TNF 10976991 729650 In the present study , we investigated effects of a synthetic glucocorticoid , dexamethasone ( Dex ) , on *dependent* activation of [NF-kappaB] and expression of the ICAM-1 gene . Regulation RELA TNF 10976991 729654 Electrophoretic mobility shift assay ( EMSA ) revealed that *dependent* activation of [NF-kappaB] was almost completely suppressed by Dex treatment . Regulation RELA TNF 11006087 735184 Pyrrolidine dithiocarbamate inhibits *dependent* activation of [NF-kappaB] by increasing intracellular copper level in human aortic smooth muscle cells . Regulation RELA TNF 11006087 735188 In the present study , we investigated effects of PDTC and another antioxidant , N-acetyl-l-cysteine (NAC) , on *dependent* activation of [NF-kappaB] in human aortic smooth muscle cells ( HASMC ) . Regulation RELA TNF 11006087 735198 These results indicate that TNF-alpha dependent expression of MCP-1 in HASMC is tightly regulated by NF-kappaB and that intracellular copper level is crucial for the *dependent* activation of [NF-kappaB] in HASMC . Regulation RELA TNF 11007940 735634 The promoter regions of the human gamma-GCS subunits contain AP-1 , [NF-kappa B] , and antioxidant response elements and are *regulated* by oxidants , growth factors , inflammatory cytokine , and anti-inflammatory agent ( dexamethasone ) in lung cells . Regulation RELA TNF 11009421 735896 A20-deficient cells fail to terminate induced [NF-kappaB] *responses* . Regulation RELA TNF 11009421 735901 Thus , A20 is critical for limiting inflammation by terminating induced [NF-kappaB] *responses* in vivo . Regulation RELA TNF 11104733 756511 Accordingly , we examined the *effects* of and cAMP on the regulation of [nuclear factor (NF)-kappaB] , a transcription factor known to modulate cytokine synthesis in numerous cell types . Regulation RELA TNF 11112449 757638 *dependent* activation of [NF-kappa B] in human osteoblastic HOS-TE85 cells is repressed in vector averaged gravity using clinostat rotation . Regulation RELA TNF 11112449 757642 Effects of vector averaged gravity on *dependent* activation of [nuclear factor kappa B (NF-kappa B)] in human osteoblastic HOS-TE85 cells were investigated by culturing the cells using clinostat rotation ( clinorotation ) . Regulation RELA TNF 11112449 757646 Electrophoretic mobility shift assays revealed that *dependent* activation of [NF-kappa B] was markedly reduced in the clinorotated cells when compared with the cells in control stationary cultures or after horizontal rotation ( motional controls ) . Regulation RELA TNF 11112449 757650 Consistent with these findings , the *dependent* induction of endogenous [NF-kappa B-responsive] genes p105 , I kappa B-alpha , and IL-8 , was significantly attenuate in clinorotated cells . Regulation RELA TNF 11133232 769111 Importantly , expression of I kappa B ( S32A , S36A ) results in complete abrogation of myocardial [NF-kappa B] activation in *response* to and LPS stimulation . Regulation RELA TNF 11198351 779643 The *effects* of on DNA binding activity of [NF-kappaB] and expression of mRNA encoding ICAM-1 ( an NF-kappaB activated gene ) were studied in human pulmonary artery endothelial ( HPAE ) cells under basal conditions and after decreasing the intracellular glutathione ( GSH ) concentration . Regulation RELA TNF 11198351 779654 Exposure of BSO treated cells to the reducing agent dithiothreitol ( DTT ) before TNFalpha treatment or supplementation of nuclear extract ( isolated after TNFalpha challenge of BSO treated cells ) with DTT significantly augmented the *effect* of on [NF-kappaB] binding activity and ICAM-1 mRNA expression . Regulation RELA TNF 11262181 796271 This indicates that isoprenylated regulatory proteins participate in the *regulation* of [NF-kappaB] by DNA damaging agents as well as by . Regulation RELA TNF 11274209 819038 However , the signal transduction pathways regulating [NF-kappaB] activation in human neutrophils in *response* to stimulation with are undefined . Regulation RELA TNF 11306890 804343 In an in vitro ICT model we show that pretreatment of RCC with IL-2 and IFNalpha leads to a diminished [NF-kB] *response* to . Regulation RELA TNF 11309390 820014 Activation of [NF-kappaB] in *response* to and glutamate was completely abolished when IP ( 3 ) receptors were blocked , and NF-kappaB activation in response to depletion of ER calcium by thapsigargin treatment was also decreased by IP ( 3 ) receptor blockade . Regulation RELA TNF 11316733 806523 In contrast to the *effect* of on [NF-kappaB] activation , Western blot analyses demonstrated that IGF-I had no effect on IkappaB phosphorylation and degradation or nuclear translocation and DNA binding of NF-kappaB . Regulation RELA TNF 11337489 827584 Taken together , this evidence strongly suggests that EGFR transactivation by , which is regulated in a redox dependent manner , is playing a pivotal *role* in TNF induced [NF-kappa B] activation . Regulation RELA TNF 11382928 820954 However , in transformed MEC , [NFkappaB] binding was initially undetectable but then increased in *response* to . Regulation RELA TNF 11420300 830591 Moreover , it seems that Ref-1 may act as a critical cofactor , mediating the induced [NF-kappaB] *response* in the vascular endothelium . Regulation RELA TNF 11420928 830780 *dependent* [NF-kappa B] activation in cultured canine keratinocytes is partly mediated by reactive oxygen species . Regulation RELA TNF 11445585 860032 Atypical lambda/iota PKC conveys 5-lipoxygenase/leukotriene B4-mediated cross-talk between phospholipase A2s regulating [NF-kappa B] activation in *response* to and interleukin-1beta . Regulation RELA TNF 11445585 860042 We have shown previously that secretory nonpancreatic ( snp ) and cytosolic ( c ) phospholipase A(2) ( PLA(2) ) regulate [NF-kappaB] activation in *response* to or interleukin (IL)-1beta activation and that a functional coupling mediated by the 5-lipoxygenase (5-LO) metabolite leukotriene B ( 4 ) ( LTB ( 4 ) ) exists between snpPLA ( 2 ) and cPLA(2) in human keratinocytes . Regulation RELA TNF 11445585 860065 Furthermore , lambda/iotaPKC and cPLA(2) phosphorylation was attenuated by phosphatidyinositol 3-kinase ( PI3-kinase ) inhibitors , which also reduced [NF-kappaB] activation in *response* to and IL-1beta , indicating a role for PI3-kinase in these processes in human keratinocytes . Regulation RELA TNF 11505050 847907 Pretreatment of HepG2 cells with IFNalpha resulted in the highest levels of [NF-kappaB] activation in *response* to TNFalpha or plus ethanol stimulation . Regulation RELA TNF 11699072 878326 To determine the role of the human coronary artery endothelial cell ( HCA-EC ) in the cytokine response to endotoxin we measured in vitro synthesis , TNF-alpha mRNA , and the associated [NF-kappa B] *response* to LPS . Regulation RELA TNF 12032830 948138 Therefore , MnSOD expression is induced by [NF-kappaB] in epithelial cancer cells in *response* to , and is at least partially responsible for their resistance to TNF-alpha induced apoptosis , presumably through the clearance of death inducing ROS . Regulation RELA TNF 12133965 967047 Mitogen activated protein kinases and [NF-kappa B] are involved in *responses* to group B streptococci . Regulation RELA TNF 12143039 969602 *dependent* activation of [NF-kappa B] induces the transcription of antiapoptotic genes that renders liver cells resistant against TNF induced apoptosis . Regulation RELA TNF 12391248 1007498 The possible *participation* of generated by mast cells in [NF-kappaB] activation by anti-IgE was investigated using a blocking Ab for TNF-alpha . Regulation RELA TNF 12411493 1010846 Siah2 efficiently decreases *dependent* induction of JNK activity and transcriptional activation of [NF-kappaB] . Regulation RELA TNF 12431991 1037097 We propose that the biphasic activation of [NF-kappaB] in *response* to may play a key regulatory role in skeletal muscle wasting associated with cachexia . Regulation RELA TNF 12543078 1028768 Together , the p43 induced production was *controlled* by [NFkB] , p38 MAPK , and ERK that is dependent on the activities of PLC and PKC . Regulation RELA TNF 12586352 1059023 Among others , the NF-kappa B-dependent zinc finger protein A20 is involved in the negative feedback regulation of [NF-kappa B] activation in *response* to . Regulation RELA TNF 12704649 1082365 In analogy with *dependent* activation of [NFkappaB] , treatment with either the anti-oxidant N-acetyl cysteine (NAC) or the cyclooxygenase (COX) inhibitor acetyl salicylic acid ( aspirin ) , but not indometacin , prevents the induction of NFkappaB dependent transcription by AII . Regulation RELA TNF 12706343 1082637 Activation of [NF-kappaB] in *response* to was intact in both cell lines . Regulation RELA TNF 12709429 1112683 The *role* of receptor associated factor ( TRAF)-1 in [NF-kappaB] activation by various members of the TNF receptor family is not well understood , and conflicting data have been published . Regulation RELA TNF 12709443 1100430 Using various deficient mouse embryonic fibroblast cells , we have compared the signaling pathways leading to [NF-kappaB] induction in *response* to and LTbetaR activation . Regulation RELA TNF 12816868 1140930 Although expression of mutant IkappaBalpha inhibited the induced [NF-kappaB] *response* , it had no effect on tumor growth in mice . Regulation RELA TNF 12882985 1142764 Absence of apolipoprotein J causes reduction of IkappaB stability , a *dependent* increase in [NF-kappaB] activity , increased transcription of the NF-kappaB target gene c-IAP and down-modulation of p53 protein . Regulation RELA TNF 14557256 1185998 receptor associated factor ( TRAF) 1 *regulates* CD40 induced TRAF2 mediated [NF-kappaB] activation . Regulation RELA TNF 14607933 1162131 *dependent* activation of [NF-kappaB] is stronger in the presence of IFN-gamma . Regulation RELA TNF 14674885 1211100 The introduction of calcium into HEK293 cells either through the activation of muscarinic cholinergic receptors or through the application of the ionophore A23187 was found to enhance *dependent* activation of [NF-kappaB] . Regulation RELA TNF 14692400 581723 In this report , we investigated the *effect* of on activation of [NF-kappa B] , c-Jun N-terminal kinase (JNK) , and apoptosis in vincristine-resistant human histiocytic lymphoma U937-VR cells . Regulation RELA TNF 15001576 1236988 The receptor associated factor ( TRAF ) protein family members are critically *involved* in activation of [NF-kappaB] , JNK , and p38 activation triggered by tumor necrosis factor (TNF) receptor family members and toll/interleukin-1 receptor ( TIR ) -containing receptors . Regulation RELA TNF 15115707 1279367 Both kinases associate with TNFR-1 in *response* to and are required for TNFR-1 serine phosphorylation , [NF-kappaB] activation , and inhibition of apoptosis . Regulation RELA TNF 15158369 1252593 In ECV304 cells overexpressing ERalpha , E ( 2 ) significantly inhibited the *effects* of on [NF-kappaB] activation , VCAM-1 expression , and U937 cell adhesion . Regulation RELA TNF 15526279 1360032 Molecular approaches to either reduce EC MLCK expression ( AdV EC MLCK antisense construct ) or to reduce kinase activity ( kinase-dead EC MLCK ATPdel mutant ) produced similar attenuation of the induced [NFkappaB] *response* . Regulation RELA TNF 15653317 1364401 Recently , the underlying mechanism by which A20 downregulates [NF-kappaB] activation in *response* to the pro-inflammatory cytokine has been described . Regulation RELA TNF 15833158 1397585 In IP , mutations in NEMO lead to the complete loss of [NF-kB] activation creating a susceptibility to cellular apoptosis in *response* to . Regulation RELA TNF 15870274 1404483 A prominent function of p62 is the regulation of [NF-kappaB] activation in *response* to interleukin-1 (IL-1) and signaling through the formation of an aPKC/p62/TRAF6 multiprotein signaling complex . Regulation RELA TNF 16186825 1468302 TAK1-deficient cells failed to activate transcription factor [NF-kappaB] and mitogen activated protein kinases in *response* to interleukin 1beta , and Toll-like receptor ligands . Regulation RELA TNF 16191192 1468319 In *response* to , latent cytoplasmic [NF-kappaB] is activated , enters the nucleus , and induces expression of inflammatory and anti-apoptotic gene expression programs . Regulation RELA TNF 16203735 1483205 Reducing Monarch-1 expression with small interference RNA in myeloid/monocytic cells caused a dramatic increase in [NFkappaB] activation and cytokine expression in *response* to TLR2/TLR4 agonists , , or M. tuberculosis infection , suggesting that Monarch-1 is a negative regulator of inflammation . Regulation RELA TNF 16288994 1484468 These results suggest that the inhibitory effect of equol on TNF-alpha expression is mediated , at least in part , by blocking [NF-kappaB] activation and the inhibition of expression by equol might be *involved* in its osteoprotective effect . Regulation RELA TNF 16318585 1487694 Further , NF-kappaB and Stat1 proteins directly regulate transcription by interacting cooperatively on [NF-kappaB-SIE] DNA binding in *response* to plus IFN-gamma . Regulation RELA TNF 16481354 1528464 Furthermore , the similarity between the phenotypes of c ( IkappaBADeltaN ) mice and mice deficient in Eda A1 ( tabby ) or its receptor EdaR ( downless ) raised the issue of whether in vivo [NF-kappaB] regulates or is *regulated* by these novel family members . Regulation RELA TNF 16644735 1583271 Mechanistically , our data indicated that , in *response* to , [NFkappaB/p65] phosphorylation and translocation as well as IkappaBalpha phosphorylation and degradation were unchanged , suggesting that Lnk does not modulate NFkappaB activity . Regulation RELA TNF 16870149 1593094 In addition , our data show that the early expression of TNF-alpha does not lead to activation of NF-kappaB , because disruption of activity by a neutralizing antibody does not *affect* nuclear translocation of [NF-kappaB] , IkappaBalpha degradation or reporter gene activation by apicidin . Regulation RELA TNF 17363555 1712975 We now report that cancer associated mutant p53 can augment the induction of [nuclear factor kappaB (NFkappaB)] transcriptional activity in *response* to the cytokine . Regulation RELA TNF 17537988 1784163 This novel finding supports a model , whereby *dependent* activation of [NF-kappaB] up-regulates phagocyte NADPH oxidase activity , leading to enhanced ROS production and further NF-kappaB activation , potentially contributing to sustained oxidant production in chronic inflammation . Regulation RELA TNF 17784835 1790513 Nuclear localization of [NF-kappaB] in *response* to was evident in differentiated , but not undifferentiated , SNUhES3 cells . Regulation RELA TNF 17878386 1797060 Furthermore , in contrast to the full-length protein , CARD8-S did not modify the expression of [NF-kappaB] target genes ( cIAP , A1 ) , in *response* to . Regulation RELA TNF 17897950 1824003 However , down-regulation of USP11 dramatically enhances [NF-kappaB] activity in *response* to , indicating that IKKalpha does not require activation of NF-kappaB . Regulation RELA TNF 17975552 1850224 We show in this study that R-Roscovitine can downregulate [nuclear factor-kappa B (NF-kappaB)] activation in *response* to and interleukin 1 . Regulation RELA TNF 18178551 1875723 Thus we conclude that endogenous Cezanne can attenuate [NF-kappaB] activation and the induction of pro-inflammatory transcripts in *response* to signaling . Regulation RELA TNF 18207479 1876661 These data demonstrate that *plays* a role in [NF-kappaB] activation and toxicity . Regulation RELA TNF 18266467 1896064 Here we demonstrate that ectopic expression of B14 inhibited [NF-kappaB] activation in *response* to , IL-1beta , poly ( I:C ) , and PMA . Regulation RELA TNF 18446055 1902768 Finally , pretreatment with pyrrolidine dithiocarbamate ( PDTC ) , an inhibitor of NF-kappaB , reduced TNF-alpha induced ICAM-1 expression and both DPI and RacN17 significantly diminished [NF-kappaB] activation in *response* to . Regulation RELA TNF 18562480 1946210 The data presented herein suggest a model whereby the TNF R1-IRAK-1 interaction integrates the cellular response to LPS , TNF-alpha , and IL-1 , culminating in a cell poised to activate *dependent* [NF-kappaB] controlled gene expression . Regulation RELA TNF 18599677 1966152 In the present review we summarize recent experimental data suggesting that mitochondrial production of reactive oxygen species , innate immunity , the local TNF-alpha converting enzyme <(TACE)-TNF-alpha> , and the renin-angiotensin system may *underlie* [NF-kappaB] induction and endothelial activation in aged arteries . Regulation RELA TNF 18676814 1943477 Encoding [NF-kappaB] temporal control in *response* to : distinct roles for the negative regulators IkappaBalpha and A20 . Regulation RELA TNF 18782567 1975930 The electromobility shift assay showed that while Cl1-0 cells exhibited low [NF-kappaB] activity in *response* to , an abundance of basal and TNF-alpha induced NF-kappaB-DNA complex was detected in Cl1-5 cells . Regulation RELA TNF 19033441 2022959 Functional complementation assays and in vivo pull-down experiments further show that ZF residues involved in ubiquitin binding are functionally important and required for [NF-kappaB] signaling in *response* to . Regulation RELA TNF 19144181 2079143 induced *regulation* of Sox9 and [NFkappaB] activity was also U0126 insensitive . Regulation RELA TNF 19262565 2062987 Lysine methyltransferase Set9 physically associates with [RelA] in vitro and in vivo in *response* to stimulation . Regulation RELA TNF 19273093 2045774 By employing TNF-alpha / IFN-gamma synergism model which causes beta -cell apoptosis , we found that the antiapoptotic X-linked inhibitor of apoptosis (XIAP) molecule is upregulated by [NF-kappaB] in *response* to and XIAP induction was inhibited by IFN-gamma induced signal transducer and activator of transcription-1 ( STAT1 ) activation , which explains the death of beta -cells by TNF-alpha /IFN-gamma synergism . Regulation RELA TNF 19302817 2064277 DNA binding activity of [NF-kappaB] , a well-known molecular effector of TNFalpha , was moreover activated by Lp(a) in a *dependent* manner and the use of the NF-kappaB inhibitor Bay 11-7082 blocked Lp(a) triggered CCL1 induction . Regulation RELA TNF 19336568 2056508 Tumor necrosis factor (TNF) receptor associated factor 2 ( TRAF2 ) is an adaptor protein that modulates the activation of the c-Jun NH ( 2 ) terminal kinase ( JNK ) /c-Jun and IkappaB kinase [(IKK)/nuclear factor-kappaB (NF-kappaB)] signaling cascades in *response* to stimulation . Regulation RELA TNF 19347279 2057483 We describe in this chapter three separate methods to determine the effects of this NEMO binding domain (NBD) peptide on pro-inflammatory [NF-kappaB] signaling in *response* to . Regulation RELA TNF 19444283 2114797 In this study , we found that p53 upregulated modulator of apoptosis ( PUMA ) , a p53 downstream target and a BH3-only Bcl-2 family member , is directly regulated by [NF-kappaB] in *response* to . Regulation RELA TNF 19927158 2203746 Furthermore , several cell types from E18 RIPK1 ( -/- ) embryos seem to activate [NF-kappaB] in *response* to . Regulation RELA TNF 20071450 2194131 Because the pathomechanism of TRAPS may involve aberrant TNF mediated intracellular signalling , we examined phosphorylation levels of [nuclear factor kappaB (NF-kappaB)] and p38 in *response* to in 10 patients with three different TNFRSF1A mutations ( C73R , C88Y and F112I ) . Regulation RELA TNF 20195534 2216374 Analysis of [NF-kappaB] activation in *response* to in MEFs reveals that IKKbeta is essential for efficient phosphorylation and subsequent degradation of IkappaB alpha , yet IKKalpha contributes to the NF-kappaB activation response in these cells as measured via DNA binding assays . Regulation RELA TNF 20231278 2254523 Maml1-deficient mouse embryonic fibroblasts showed impaired induced [NF-kappaB] *responses* . Regulation RELA TNF 20478530 2263058 TAK1 mediated cancer suppression is exerted through activating [NF-kappaB] in *response* to and through preventing Caspase-3 dependent hepatocyte and cholangiocyte apoptosis . Regulation RELA TNF 20550880 2279633 Up-regulating the expression of occludin and down *regulating* the expressions of TLR4 and [NF-kappaB] , and hence inhibiting expression and improving the mucosa barrier function may be part of the mechanisms of BWXLS in treating oxazolone induced colitis in mice . Regulation RELA TNF 21601601 2464270 TAK1 mediated cancer suppression is exerted through activating [NF-kappaB] in *response* to and through preventing Caspase-3 dependent hepatocyte and cholangiocyte apoptosis . Regulation RELA TNF 22895565 2713535 Interestingly , reduction of MMS22L by siRNAs in cancer cells inhibited the *dependent* activation of [RelA/p65] in the NFKB pathway and expression of its downstream anti-apoptotic molecules such as Bcl-XL and TRAF1 . Regulation RELA TNF 23174100 2700548 Our results showed that TNF-alpha treatment increased Bcl-2 mRNA and protein levels in breast cancer cells , suggesting that Bcl-2 is directly regulated by [nuclear factor-kappaB (NF-kappaB)] in *response* to . Regulation RELA TNF 7532017 286152 Under our conditions , all three IFNs potentiated the cytotoxic *effects* of but had no effect on the TNF dependent [NF-kappa B] activation . Regulation RELA TNF 7642536 317970 Here we examine the inductions of [NF-kappa B] in serum deprived and cycling cells in *response* to . Regulation RELA TNF 7852340 294442 *dependent* activation of a [RelA] homodimer in astrocytes . Regulation RELA TNF 7929839 274676 Both PDTC and HMAP attenuated the increase in nuclear [NF-kB] in *response* to either or IgG complexes . Regulation RELA TNF 7929839 274680 Preincubation of cells with 8 br-cAMP , forskolin , or PGE2 attenuated the increase in nuclear [NF-kB] in *response* to , aggregated IgG , or superoxide anion . Regulation RELA TNF 7957109 278012 Micromolar amounts of the peptide Cbz-Ile-Glu ( O-t-Bu ) -Ala-leucinal ( PSI ) , a specific inhibitor of the chymotrypsin-like activity of the proteasome , prevented activation of [NF-kappa B] in *response* to and okadaic acid ( OA ) through inhibition of I kappa B-alpha degradation . Regulation RELA TNF 7981153 281397 Furthermore , activation of [NFkB] was also induced in NPD type A fibroblasts in *response* to IL-1 alpha and stimulation to a similar extent as in normal fibroblasts . Regulation RELA TNF 8349660 227109 C2-ceramide , however , enhanced activation of [NF-kappa B] in *response* to with peak effects observed at a concentration of C2-ceramide of 5 microM . Regulation RELA TNF 8521084 336412 However several questions regarding the molecular mechanisms involved in particular steps of these cascades remain largely unresolved : how and at which subcellular level , do the cells produce these reactive oxygen intermediates that will contribute to [NF kappa B] activation in *response* to IL-1 or ? Regulation RELA TNF 8655581 366983 We report here that both kappa B-dependent transactivation of a reporter gene and [NF-kappa B] activation in *response* to tumor necrosis factor ( ) or H2O2 treatments are deficient in human T47D cell transfectants that overexpress seleno-glutathione peroxidase ( GSHPx ) . Regulation RELA TNF 8724035 373772 An enhanced [nuclear factor (NF)-kappa B] activation in *response* to has been observed in stably tat transfected cells . Regulation RELA TNF 8804426 382179 [NF-kappa B-mediated] *regulation* of urokinase gene expression by PMA and in human A549 cells . Regulation RELA TNF 8831497 385732 However , the intracellular signaling pathways that activate endothelial [NF-kappa B] and JNK in induced *responses* are unknown . Regulation RELA TNF 8849369 359031 To examine whether [nuclear factor kappaB (NF-kappaB)] is activated in cultured synovial cells in *response* to and to investigate the correlation between NF-kappaB activation and synovial cell proliferation . Regulation RELA TNF 8852698 387845 Analysis of DNA binding revealed that [NF-kappa B] activation in *response* to was significantly inhibited under these conditions . Regulation RELA TNF 8947041 400457 We have created mutant cell lines that are unable to activate [NF-kappaB] in *response* to . Regulation RELA TNF 9126284 426482 This pretreatment also inhibited activation of [NF-kappa B] in *response* to in lymphoblastoid J.Jhan5-1 cells . Regulation RELA TNF 9310124 454812 Exogenous and the monoclonal antibody to TNF-alpha did not *affect* IL-10 production and constitutive [NF-kappa B] binding levels in HuT 78 cells . Regulation RELA TNF 9351830 466081 Microinjection of the inhibitory peptides into stimulated cells abolished [NF-kappa B] activation in *response* to and the consequent expression of E-selectin , an NF-kappa B-dependent cell-adhesion molecule . Regulation RELA TNF 9383399 345228 Cell lines stably overexpressing the H2O2 degrading enzyme catalase were deficient in activating [NF-kappa B] in *response* to or okadaic acid . Regulation RELA TNF 9501011 491007 We demonstrate that adenovirus mediated overexpression of I kappa B alpha , an inhibitor of [NF-kappa B] suppresses the expression of piap in *response* to suggesting that piap is one of the NF-kappa B regulated genes that operates to prevent programmed cell death of EC in inflammation . Regulation RELA TNF 9506462 491345 *dependent* activation of [NF-kappaB] could be blocked partially by both anti-p60 and anti-p80 , suggesting that TNF mediates its effect independently through the p60 and p80 receptors . Regulation RELA TNF 9528954 496213 The present study examined the *effects* of on the activation of [nuclear factor-kappa B (NF-kappaB)] and on the expression of interleukin (IL)-6 gene in rat thyroid FRTL-5 cells . Regulation RELA TNF 9580637 504962 N-tosyl-L-phenylalanine chloromethyl ketone ( TPCK ) , a serine protease inhibitor , inhibited I kappa B-alpha degradation and [NF-kappa B] activation in *response* to in a dose dependent manner ( 25 , 50 , 100 microM ) . Regulation RELA TNF 9624136 511364 Furthermore , the *effect* of on [NFkappaB] activation was rapid , whereas C2-ceramide required an optimal treatment time of 1 h. Interestingly , TNF was found to increase ceramide in cells but only after a 1-h contact time . Regulation RELA TNF 9718198 528174 We thus examined the *effect* of on the activation of [NF-kappaB] in rat osteoblast-like osteosarcoma cells ( ROS17/2.8 ) . Regulation RELA TNF 9724652 529510 Moreover , inhibition of TAFII105 activity by overexpression of a dominant negative mutant of TAFII105 decreased [NF-kappaB] transcriptional activity and severely reduced cell survival in *response* to . Regulation RELA TNF 9819420 547293 MEKK1 is activated by tumor necrosis factor alpha (TNF-alpha) and interleukin-1 and can potentiate the stimulatory *effect* of on IKK and [NF-kappaB] activation . Regulation RELA TNF 9823429 549007 We found that resistance to increasing concentrations of 9NC correlated with resistance to *dependent* activation of [NF-kappa B] . Regulation RELA TNFSF10 10807904 736601 Taken together , our data suggest that TRAIL-R1 responds to either cross linked or non-cross linked sTRAIL which signals NF-kappaB activation and apoptosis , whereas TRAIL-R2 signals [NF-kappaB] activation , apoptosis , and JNK activation only in *response* to cross linked . Regulation RELA TNFSF10 11313369 805413 Furthermore , studies with NF-kappaB reporter constructs revealed that the resistance of melanoma lines to TRAIL induced apoptosis was correlated to activation of [NF-kappaB] in *response* to . Regulation RELA TNFSF10 15498932 1325590 *effects* on mitochondrial [NF-kappaB-DNA] binding and mitochondrial genome encoded mRNA levels also depend on Bcl-2 overexpression . Regulation RELA TNFSF10 16024612 1435234 Specifically , it is not yet understood how *controls* [nuclear factor kappaB (NF-kappaB)] activation and overcomes its anti-apoptotic effect . Regulation RELA TNFSF10 16645643 1672031 Both addition of IGFBP-3 protein to cell cultures or enforced expression of IGFBP-3 in the HT29 carcinoma cell line inhibited [nuclear factor kappa B (NF-kappaB)] activation in *response* to the induction of apoptosis by . Regulation RELA TNFSF10 16785986 1645939 In these cells , the predominant *effect* of receptor activation is the activation of [nuclear factor-kappaB (NF-kappaB)] , which promotes tumor metastases and invasion . Regulation RELA TNFSF10 20354842 2260908 In the present work , we analyzed cell viability , DISC formation as well as IL-8 and [NF-kappaB] activation side by side in *responses* to and agonistic antibodies against DR4 ( mapatumumab ) and against DR5 ( lexatumumab ) in pancreatic ductal adenocarcinoma cells . Regulation RELB TNF 16192349 1468341 Our findings demonstrate that RelA has a major regulatory role serving to dampen [RelB] activity in *response* to and define a previously unrecognized mechanism that represents an essential step leading to selective NF-kappaB target gene expression . Regulation REN EDN2 18407094 209518 Recent reports , however , suggest that may affect the release of the pituitary hormones and *control* the levels of atrial natriuretic peptide , [renin] , and the catecholamines . Regulation REN EDN2 2018117 157091 *Effects* of on in vitro [renin] secretion . Regulation REN EDN2 2045149 160264 Using microdissected rabbit afferent arterioles , we studied the vascular response to synthetic endothelin and its interaction with EDRF and the *effect* of on [renin] release . Regulation REN EDN2 2045149 160270 Basal [renin] release was 0.62 +/- 0.15 ng angiotensin I/hr/afferent arterioles/hr ( n = 13 ) and was not *affected* by ( 10 ( -10 ) to 10 ( -6 ) M ) . Regulation REN EDN2 2464732 104908 The *effect* of , a newly identified endothelium derived vasoconstrictor peptide , on [renin] release from rat kidney cortical slices was examined . Regulation REN EDN2 2680527 121051 *Effects* of on renal function and [renin] secretion in anesthetized rats . Regulation REN EDN2 2698938 125122 Vasoconstriction and inhibition of renin release by endothelin are attenuated in the presence of a protein kinase C inhibitor , staurosporine , which suggests that protein kinase C helps to mediate the *effects* of on [renin] secretion and vascular resistance . Regulation REN EDN2 3052444 99494 The *effect* of on [renin] release from isolated rat glomeruli was examined . Regulation REN EDN2 3052444 99500 did not *affect* this nifedipine induced [renin] release . Regulation REN EDN2 3061378 101826 We studied the *effect* of on [renin] release in a dynamic superfusion system of dispersed rat juxtaglomerular ( JG ) cells . Regulation REN EDN2 8102503 225893 Inhibitory *effect* of on [renin] release in dog kidneys . Regulation REN EDN2 8102503 225896 To investigate the *effect* of on [renin] release , experiments were performed in barbiturate anaesthetized dogs with denervated kidneys . Regulation REN EDN2 8102503 225899 During ureteral occlusion the inhibitory *effect* of on [renin] release either during inhibition of beta-adrenergic activity with propranolol or after inhibiting prostaglandin synthesis by indomethacin during intrarenal infusion of isoproterenol was examined . Regulation REN EDN2 9186867 436896 Since endothelin is a potent mediator of Ca2+ influx and an inhibitor of renin release , we tested whether or not could be *involved* in the inhibitory effect of L-NAME on [renin] secretion . Regulation REN EDN2 9857381 555451 Nitric oxide ( NO ) and ( ET-1 ) are *involved* in the regulation of [renin] release and modulate the vasoconstrictive and fibrogenic effects of angiotensin II . Regulation REN IL1B 16959849 1639690 The decrease in retinoic acid induced [renin] promoter activity in *response* to was blocked with the general tyrosine kinase inhibitor Genistein . Regulation REN IL1B 16959849 1639708 PD98059 , an Erk kinase inhibitor , significantly decreased IL-1beta mediated phosphorylation of ERK1/2 , and attenuated the repression of baseline [renin] transcription in *response* to . Regulation REN PTGER2 14711886 1219529 Although there is substantial evidence that PGE ( 2 ) acting through either the EP(2) or EP(4) receptor stimulates renin synthesis in the adult kidney , our results have demonstrated that before the completion of nephrogenesis , cortisol down-regulation of [renin] mRNA expression is *independent* of any change in the expression of PGHS-2 , , or EP(4) mRNA expression . Regulation REN RASD1 21247419 2386873 interacts with Ear2 ( Nr2f6 ) to *regulate* [renin] transcription . Regulation REN TNF 12376397 996789 Therefore we have tested the *effect* of on [renin] transcription in As4.1 cells , which represent transformed mouse JG cells , and in native mouse JG cells in culture . Regulation REN TNF 2104586 126824 We have studied the direct *effects* of recombinant and purified and IL-1 on [renin] secretion using both static incubations and perifusions of rat renal cortical slices . Regulation REN TNF 2104586 126828 The stimulatory *effects* of and IL-1 on [renin] were reversible . Regulation REN TNF 2104586 126832 Since the *effect* of and IL-1 on [renin] can be blocked by a ( CO ) inhibitor , the studies indicate a role of prostaglandins in their action . Regulation REN TNF 8724359 376726 In addition to inhibiting basal renin expression , IFN gamma potentiated the inhibitory *effect* of on [renin] expression . Regulation RENBP EPHB2 21575204 2441463 [AGE-BSA] down-regulated Cx43 expression in HAEC , mainly through reduced Cx43 transcription , and the process *involved* activation of and p38 MAPK . Regulation REPIN1 CTGF 21228219 2408997 TGFß repression of SALL2 and [AP4] is *independent* of the induction of by TGFß . Regulation RETN FOXO1 24291305 2898895 It can be regulated by transcriptional factors , but the possible *role* of forkhead transcription factor in regulating [resistin] gene expression is still unknown . Regulation RETN TNF 12943526 1133693 Moreover , we studied the *effects* of , a known mediator of insulin resistance , on the expression of AM and [resistin] in 3T3-L1 adipocytes . Regulation RETN TNF 16116950 1449110 *Effect* of on [resistin] expression in 3T3-L1 adipocytes and its mechanism . Regulation RETN TNF 16116950 1449111 In order to investigate the *effect* of on [resistin] expression in 3T3-L1 adipocytes , and further explore its mechanisms , the differentiated 3T3-L1 adipocytes were incubated with 0 , 1 , 10 , 100 ng/mL TNFalpha respectively for 24 h , and then the expression of resistin was determined . Regulation RETN TNF 18369347 1912825 In order to characterize the regulation of resistin gene expression , we explore the *effect* of on [resistin] mRNA expression and its underlying mechanism in 3T3-L1 adipocytes . Regulation RETN TNF 18369347 1912832 Pretreatment with L-NAME and PBITU significantly reversed the TNF-alpha induced downregulation of resistin expression , while treatment with SNP mimicked the inhibitory *effect* of on [resistin] expression . Regulation RGS1 RGS2 22359476 2520900 [RGS1] , RGS2 , RGS4 , and RGS16 are expressed in the pancreas , and *regulates* G-protein coupled receptor (GPCR) induced Ca ( 2+ ) oscillations . Regulation RGS16 NOS2 19588733 2105268 The significant increase in [RGS16] mRNA expression in VSMCs by LPS was time- and concentration dependent but *independent* of increased activity . Regulation RGS16 RGS2 22359476 2520901 RGS1 , RGS2 , RGS4 , and [RGS16] are expressed in the pancreas , and *regulates* G-protein coupled receptor (GPCR) induced Ca ( 2+ ) oscillations . Regulation RGS16 RGS4 14634662 1170959 does not bind G alpha 13 or attenuate G alpha 13-dependent responses , and neither [RGS16] nor RGS4 *affects* G alpha 12-mediated signalling . Regulation RGS2 ADCY3 11234015 789697 [RGS2] *regulates* signal transduction in olfactory neurons by attenuating activation of . Regulation RGS2 ADM 24154573 2885762 This study aimed to observe the changes of [RGS2] expression in *response* to and ADT in cultured vascular smooth muscle cells and to clarify the potential signaling pathways in vitro . Regulation RGS2 ANGPT2 16627589 1583053 We studied *regulation* of [RGS2] , the role of RGS2 in steroidogenesis , and the intracellular signal events involved in H295R human adrenal cells . Regulation RGS2 HSF1 23587726 2789487 A single nucleotide change identified in the RGS2 promoter of hypertensive patients abolished *regulated* expression of [RGS2] , suggesting that activated HSF1 is involved in blood pressure regulation via modulation of RGS2 expression . Regulation RGS2 PPP1R9B 16895908 1625736 Finally , the scaffolding protein , shown to recruit RGS2 and regulate GPCR signaling via G ( alpha ) , did not *affect* [RGS2] binding and electrophysiological properties of TRPV6 , indicating a GPCR independent mechanism of TRPV6 regulation by RGS2 . Regulation RGS2 PTH 10614620 656290 These findings demonstrate that [RGS2] is *regulated* by , prostaglandin E2 , and PTHrP and that regulation by PTH in bone occurs via the cAMP pathway . Regulation RGS2 PTH 11573967 864905 RGS2 ( Regulator of G protein Signaling 2 ) mRNA was rapidly and transiently increased only by PTH analogs ( PTH1-84 , 1-34 , 1-31 , and PTHrP ) that activated the Galphas mediated cAMP/PKA signaling pathway , whereas activation of the Galphaq mediated Ca ( 2+ ) /PKC signaling pathway by had no *effect* on [RGS2] expression . Regulation RGS2 PTHLH 10614620 656291 These findings demonstrate that [RGS2] is *regulated* by PTH , prostaglandin E2 , and and that regulation by PTH in bone occurs via the cAMP pathway . Regulation RGS2 TGFB1 12225869 987871 Among the novel genes , the mRNA levels for the high mobility group protein 1 (hmg-1) , the [regulator of G-protein signaling 2] ( rgs-2 ) , the inducible early growth *response* ( tieg ) , the inhibitor of DNA binding 3 (id3) , and the heterogeneous nuclear ribonucleoprotein H ( hnrnp h ) were changed following injury . Regulation RGS2 TGFB2 12225869 987872 Among the novel genes , the mRNA levels for the high mobility group protein 1 (hmg-1) , the [regulator of G-protein signaling 2] ( rgs-2 ) , the inducible early growth *response* ( tieg ) , the inhibitor of DNA binding 3 (id3) , and the heterogeneous nuclear ribonucleoprotein H ( hnrnp h ) were changed following injury . Regulation RGS2 TGFB3 12225869 987873 Among the novel genes , the mRNA levels for the high mobility group protein 1 (hmg-1) , the [regulator of G-protein signaling 2] ( rgs-2 ) , the inducible early growth *response* ( tieg ) , the inhibitor of DNA binding 3 (id3) , and the heterogeneous nuclear ribonucleoprotein H ( hnrnp h ) were changed following injury . Regulation RGS4 IL1B 18260825 1895996 These results suggest that the canonical IKK2/IkappaBalpha pathway of NF-kappaB activation mediates the up-regulation of [RGS4] expression in *response* to and contributes to the inhibitory effect of IL-1beta on acetylcholine stimulated PLC-beta dependent initial contraction in rabbit colonic smooth muscle . Regulation RGS4 RGS16 14634662 1170954 [RGS4] does not bind G alpha 13 or attenuate G alpha 13-dependent responses , and neither nor RGS4 *affects* G alpha 12-mediated signalling . Regulation RGS4 RGS2 22359476 2520899 RGS1 , RGS2 , [RGS4] , and RGS16 are expressed in the pancreas , and *regulates* G-protein coupled receptor (GPCR) induced Ca ( 2+ ) oscillations . Regulation RGS7 TNF 12077120 976071 Interaction of 14-3-3 protein with [regulator of G protein signaling 7] is dynamically *regulated* by . Regulation RHO F2R 20874501 2331946 *dependent* [rho/Rho] kinase activation led to increase in ppET-1 mRNA and mature ET-1 secretion . Regulation RHO TMOD1 24130935 2714742 Ethanol significantly inhibited thromboxane A2 mimetic induced contraction with intact endothelial function , but there was no relaxation on thromboxane A2 mimetic U-46619 induced contraction irrespective of endothelium suggesting that the pathway such as [Rho-kinase] activation , Ca ( 2+ ) entry or *regulation* was not affected . Regulation RHO TNF 21153131 345654 Dyscohesion induced by this cytokine is associated with perturbation of the actin cytoskeleton which may be due to the regulatory *role* of on [Rho] . Regulation RHOA CAPN8 11964413 953776 Here we show that is also *involved* in inactivating [RhoA] during integrin induced signaling . Regulation RHOA EPHB2 12892714 1117821 signaling coordinately *regulates* activity of Rac1 and [RhoA] for tumor cell motility . Regulation RHOA EPHB2 15494214 1354875 These studies indicate a direct *involvement* of in the alpha ( 1 ) -adrenergic activation of NHE1 and a significant role for both ERK and [RhoA] in LPA stimulation of NHE1 in CCL39 fibroblasts . Regulation RHOA IFI27 19829074 2159896 Further characterization of post-translational modifications governing localization and its *action* on [RhoA] and the actin cytoskeleton may provide critical insights into human cancer metastasis . Regulation RHOA IFI27 24535918 2942608 In this study , we investigated the mechanisms of 3MC mediated downregulation of cytosolic p21/ , and the *effects* of 3MC on [RhoA] activation and cell migration , in mouse cerebral vascular endothelial cells ( MCVECs ) . Regulation RHOA PLAU 12719789 1084092 Endogenous [RhoA] , but not Rac1 or Cdc42 , was significantly activated in *response* to . Regulation RHOA RARB 16849557 1588580 RRIG1 mediates *effects* of on tumor cell growth and gene expression through binding to and inhibition of [RhoA] . Regulation RHOA SLC6A2 20547485 2302057 Taken together , our results demonstrate that Smad3 *regulates* [RhoA] activation and cytoskeletal reorganization by controlling in TGF-beta1 induced ARPE-19 cells . Regulation RHOA SPHK1 23658376 2810838 These data suggest that FXa induces expression and increases S1P formation independent of thrombin and that this *involves* the activation of [Rho A] and PKC signalling . Regulation RHOA TNF 19602845 2118011 In the present study , the *effect* of on [RhoA] protein expression was examined in cultured human bronchial smooth muscle cells ( hBSMCs ) . Regulation RIPK3 TNF 16948920 1610129 Immunofluorescence was used to determine the subcellular localization of RIP3 in NIH3T3 cell line and the *effects* of and z-VAD.fmk on [RIP3] for its localization changing . Regulation RLN1 EPHB2 22835547 2670974 Studies using chemical inhibitors and siRNAs to signaling molecules showed that PI3K , Akt , and PKC-? and the transcription factors Elk-1 , c-fos and , to a lesser extent , NF-?B are *involved* in [relaxin] 's induction of MMP-9 . Regulation RLN2 EPHB2 22835547 2670975 Studies using chemical inhibitors and siRNAs to signaling molecules showed that PI3K , Akt , and PKC-? and the transcription factors Elk-1 , c-fos and , to a lesser extent , NF-?B are *involved* in [relaxin] 's induction of MMP-9 . Regulation RLN3 EPHB2 22835547 2670976 Studies using chemical inhibitors and siRNAs to signaling molecules showed that PI3K , Akt , and PKC-? and the transcription factors Elk-1 , c-fos and , to a lesser extent , NF-?B are *involved* in [relaxin] 's induction of MMP-9 . Regulation RNASE1 AZGP1 10462714 640120 We believe that the *role* of in differentiation and its [RNase] activity are two likely suspects as agents of the inhibition of proliferation . Regulation RNASE1 COIL 23616925 2774884 Additionally , we provide evidence of specific [RNase] activity *regulation* , on both U2 and hTR transcripts , by phosphorylation of a single residue , serine 489 . Regulation RNASE1 DNASE1 8594414 335334 The effect of L-RNA was dependent of the integrity of the polynucleotide chain and was not due to LPS contamination since its ability to induce MNCF and IL-8 release was strongly reduced by [RNase] but was not *affected* by or polymyxin B . Regulation RNASE1 DNASE2 8594414 335335 The effect of L-RNA was dependent of the integrity of the polynucleotide chain and was not due to LPS contamination since its ability to induce MNCF and IL-8 release was strongly reduced by [RNase] but was not *affected* by or polymyxin B . Regulation RNASE1 EDC3 11767103 890323 This result may explain why the [RNase] activity towards poly C was not *affected* by as mentioned above . Regulation RNASE1 EDC4 11767103 890322 This result may explain why the [RNase] activity towards poly C was not *affected* by as mentioned above . Regulation RNASE1 HBD 20875084 2337260 Tma-CD lost the ability to suppress the RNase H deficiency of an E. coli rnhA mutant , indicating that the is *responsible* for in vivo [RNase] H activity . Regulation RNASE1 MCOLN1 9155039 431580 [I-RNase] is *dependent* and specifically degrades single stranded I-RNA . Regulation RNASE1 MCOLN1 9888800 585192 In contrast , the rnh ( rnhB ) gene product ( RNase HII ) showed a preference for Mn2+ , as did E. coli RNase HII , whereas the ysgB ( rnhC ) gene product ( RNase HIII ) exhibited a *dependent* [RNase] H activity . Regulation RNASE1 OR10A4 19320830 2064407 These findings suggest that *controls* [RNase] E synthesis by binding to RNase E and expediting cleavage elsewhere within the rne transcript . Regulation RNASE1 PSMA1 18346191 2008389 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE1 PSMA2 18346191 2008390 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE1 PSMA3 18346191 2008391 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE1 PSMA4 18346191 2008392 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE1 PSMA5 18346191 2008393 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE1 PSMA6 18346191 2008394 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE1 PSMA7 18346191 2008395 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE1 PSMB1 18346191 2008396 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE1 PSMB2 18346191 2008397 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE1 PSMB3 18346191 2008398 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE1 PSMB4 18346191 2008399 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE1 PSMB5 18346191 2008400 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE1 PSMB6 18346191 2008401 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE1 PSMB7 18346191 2008402 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE1 PSMC1 18346191 2008403 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE1 PSMC2 18346191 2008404 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE1 PSMC3 18346191 2008405 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE1 PSMC4 18346191 2008406 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE1 PSMC5 18346191 2008407 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE1 PSMC6 18346191 2008408 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE1 PSMD13 18346191 2008409 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE1 PSMD4 18346191 2008410 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE1 RNH1 2461303 100138 The 8.3-nm receptor form was converted to the 7.1-nm receptor form after treatment by [ribonuclease A] in the presence of molybdate and this effect was dose *dependent* , being completely prevented by ( RNasin ) . Regulation RNASE1 RNH1 8448385 213982 RNase A and angiogenin are strongly inhibited by human , whereas the [RNase] activity and tumour cell agglutination activity of SBL are not *affected* by this inhibitor . Regulation RNASE1 SAMHD1 25038827 2953330 Furthermore , phosphorylation of at T592 negatively *regulates* its [RNase] activity in cells and impedes HIV-1 restriction . Regulation RNASE1 TRAF3 10087233 599829 Those against PB1 and PB2 inhibited the *dependent* [RNase] activity , but those against PB2 alone slightly inhibited the cap-I binding activity . Regulation RNASE1 TRAF3 10087233 599853 and amino acids 301-517 and 601-716 of PA inhibited the *dependent* [RNase] activity . Regulation RNASE1 TRH 1324930 195095 Here we show that *regulates* [RNase] activity in GH3 cells and that specific mRNA sequences are needed for in vivo regulation of TRH-R mRNA by TRH . Regulation RNASE1 TRH 1324930 195107 *affected* [RNase] activity in a biphasic manner with rapid stimulation ( by 10 min ) followed by a decrease to a rate slower than in control lysates within 6 h . Regulation RNASE1 TRH 1324930 195131 These data show that *regulates* [RNase] activity in GH3 cells , that the 3'-untranslated region bestows decreased stability on TRH-R mRNA and that the 3 ' end of the mRNA is necessary for regulation by TRH of TRH-R mRNA degradation . Regulation RNASE1 TYR 8844858 387579 The *role* of 97 in the thermal stability of [RNase A] is large . Regulation RNASE1 UMOD 10066745 593670 No *effect* of ( A ) on the activity of DNase I , [RNase A] , and Taq DNA polymerase was noticed . Regulation RNASE7 AZGP1 10462714 640128 We believe that the *role* of in differentiation and its [RNase] activity are two likely suspects as agents of the inhibition of proliferation . Regulation RNASE7 COIL 23616925 2774892 Additionally , we provide evidence of specific [RNase] activity *regulation* , on both U2 and hTR transcripts , by phosphorylation of a single residue , serine 489 . Regulation RNASE7 DNASE1 8594414 335350 The effect of L-RNA was dependent of the integrity of the polynucleotide chain and was not due to LPS contamination since its ability to induce MNCF and IL-8 release was strongly reduced by [RNase] but was not *affected* by or polymyxin B . Regulation RNASE7 DNASE2 8594414 335351 The effect of L-RNA was dependent of the integrity of the polynucleotide chain and was not due to LPS contamination since its ability to induce MNCF and IL-8 release was strongly reduced by [RNase] but was not *affected* by or polymyxin B . Regulation RNASE7 EDC3 11767103 890339 This result may explain why the [RNase] activity towards poly C was not *affected* by as mentioned above . Regulation RNASE7 EDC4 11767103 890338 This result may explain why the [RNase] activity towards poly C was not *affected* by as mentioned above . Regulation RNASE7 HBD 20875084 2337268 Tma-CD lost the ability to suppress the RNase H deficiency of an E. coli rnhA mutant , indicating that the is *responsible* for in vivo [RNase] H activity . Regulation RNASE7 IL1A 20967562 2424762 Blocking the MAPKs resulted in inhibition of [RNase-7] expression in *response* to . Regulation RNASE7 MCOLN1 9155039 431588 [I-RNase] is *dependent* and specifically degrades single stranded I-RNA . Regulation RNASE7 MCOLN1 9888800 585200 In contrast , the rnh ( rnhB ) gene product ( RNase HII ) showed a preference for Mn2+ , as did E. coli RNase HII , whereas the ysgB ( rnhC ) gene product ( RNase HIII ) exhibited a *dependent* [RNase] H activity . Regulation RNASE7 OR10A4 19320830 2064427 These findings suggest that *controls* [RNase] E synthesis by binding to RNase E and expediting cleavage elsewhere within the rne transcript . Regulation RNASE7 PSMA1 18346191 2008565 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE7 PSMA2 18346191 2008566 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE7 PSMA3 18346191 2008567 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE7 PSMA4 18346191 2008568 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE7 PSMA5 18346191 2008569 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE7 PSMA6 18346191 2008570 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE7 PSMA7 18346191 2008571 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE7 PSMB1 18346191 2008572 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE7 PSMB2 18346191 2008573 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE7 PSMB3 18346191 2008574 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE7 PSMB4 18346191 2008575 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE7 PSMB5 18346191 2008576 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE7 PSMB6 18346191 2008577 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE7 PSMB7 18346191 2008578 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE7 PSMC1 18346191 2008579 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE7 PSMC2 18346191 2008580 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE7 PSMC3 18346191 2008581 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE7 PSMC4 18346191 2008582 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE7 PSMC5 18346191 2008583 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE7 PSMC6 18346191 2008584 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE7 PSMD13 18346191 2008585 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE7 PSMD4 18346191 2008586 All these results suggest that *dependent* degradation of [S-RNase] may be an integral part of the S-RNase based self-incompatibility mechanism . Regulation RNASE7 RNH1 8448385 213990 RNase A and angiogenin are strongly inhibited by human , whereas the [RNase] activity and tumour cell agglutination activity of SBL are not *affected* by this inhibitor . Regulation RNASE7 SAMHD1 25038827 2953338 Furthermore , phosphorylation of at T592 negatively *regulates* its [RNase] activity in cells and impedes HIV-1 restriction . Regulation RNASE7 TRAF3 10087233 599837 Those against PB1 and PB2 inhibited the *dependent* [RNase] activity , but those against PB2 alone slightly inhibited the cap-I binding activity . Regulation RNASE7 TRAF3 10087233 599861 and amino acids 301-517 and 601-716 of PA inhibited the *dependent* [RNase] activity . Regulation RNASE7 TRH 1324930 195103 Here we show that *regulates* [RNase] activity in GH3 cells and that specific mRNA sequences are needed for in vivo regulation of TRH-R mRNA by TRH . Regulation RNASE7 TRH 1324930 195115 *affected* [RNase] activity in a biphasic manner with rapid stimulation ( by 10 min ) followed by a decrease to a rate slower than in control lysates within 6 h . Regulation RNASE7 TRH 1324930 195139 These data show that *regulates* [RNase] activity in GH3 cells , that the 3'-untranslated region bestows decreased stability on TRH-R mRNA and that the 3 ' end of the mRNA is necessary for regulation by TRH of TRH-R mRNA degradation . Regulation RNF19A TNF 15001576 1236986 The receptor associated factor ( TRAF ) protein family members are critically *involved* in activation of NF-kappaB , JNK , and [p38] activation triggered by tumor necrosis factor (TNF) receptor family members and toll/interleukin-1 receptor ( TIR ) -containing receptors . Regulation RNGTT F2R 12506061 1038284 [HCE-T] expression of cytokines ( IL-6 , IL-8 , and TNFalpha ) in *response* to activation of and -2 was measured by quantitative RT-PCR and ELISA . Regulation ROCK1 IFI27 22584582 2614292 During the G ( 1 ) -S transition , the activity of Cdk2 is *regulated* by its association with ( KIP1 ) , which in rodent fibroblasts undergoes phosphorylation mainly at serine 10 , threonine 187 , and C-terminal threonine 197 by KIS , Cdk2 , and Pim or [ROCK] , respectively . Regulation ROCK1 NEDD9 22328516 2592254 overexpression does not *affect* [ROCK] signalling through activation of RhoA but decreases ROCKII signalling through Src dependent phosphorylation of a negative regulatory site Tyr722 . Regulation ROCK2 IFI27 22584582 2614293 During the G ( 1 ) -S transition , the activity of Cdk2 is *regulated* by its association with ( KIP1 ) , which in rodent fibroblasts undergoes phosphorylation mainly at serine 10 , threonine 187 , and C-terminal threonine 197 by KIS , Cdk2 , and Pim or [ROCK] , respectively . Regulation ROCK2 NEDD9 22328516 2592255 overexpression does not *affect* [ROCK] signalling through activation of RhoA but decreases ROCKII signalling through Src dependent phosphorylation of a negative regulatory site Tyr722 . Regulation RORC REL 21940679 2497482 Consistent with this finding , was activated in response to TCR signaling in the early stages of Th17 development and *controlled* the expression of [Rorc] , which encodes the Th17 transcription factor retinoic acid related orphan receptor ?t . Regulation RPA1 FLG 22174424 2558085 The aim of the present study was to investigate the *participation* of platelet derived growth factor (PDGF)-A , PDGF-B , PDGF-Ra , fibroblast growth factor (FGF)-2 , and BEK in PA , [RPA] and recurrent pleomorphic adenoma with malignant transformation ( TRPA ) . Regulation RPA2 FLG 22174424 2558089 The aim of the present study was to investigate the *participation* of platelet derived growth factor (PDGF)-A , PDGF-B , PDGF-Ra , fibroblast growth factor (FGF)-2 , and BEK in PA , [RPA] and recurrent pleomorphic adenoma with malignant transformation ( TRPA ) . Regulation RPE IGFBP1 19540231 2142413 These findings have important implications for understanding the mechanisms of *actions* on the [RPE] , and in particular suggest a role for IGFBP-endocytosis . Regulation RPL17 STAT4 24711622 2935589 STAT3 , , NFATc1 , and CTCF *regulate* [PD-1] through multiple novel regulatory regions in murine T cells . Regulation RPS10 EPHB2 14563318 1154433 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS11 EPHB2 14563318 1154447 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS12 EPHB2 14563318 1154461 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS13 EPHB2 14563318 1154475 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS14 EPHB2 14563318 1154489 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS15 EPHB2 14563318 1154503 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS16 EPHB2 14563318 1154517 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS17 EPHB2 14563318 1154531 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS18 EPHB2 14563318 1154545 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS19 EPHB2 14563318 1154559 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS2 EPHB2 14563318 1154573 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS20 EPHB2 14563318 1154587 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS21 EPHB2 14563318 1154601 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS23 EPHB2 14563318 1154615 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS24 EPHB2 14563318 1154629 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS25 EPHB2 14563318 1154643 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS26 EPHB2 14563318 1154657 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS27 EPHB2 14563318 1154671 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS27 STK39 18083840 1837452 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation RPS28 EPHB2 14563318 1154685 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS29 EPHB2 14563318 1154699 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS3 EPHB2 14563318 1154713 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS5 EPHB2 14563318 1154727 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS6 EPHB2 14563318 1154741 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS6KA1 EPHB2 17627032 1770182 Here , we show for the first time that in all four brain lesions and one angiomyolipoma from TS patients both extracellular signal regulated kinase ( Erk ) and p90 ribosomal S6 kinase 1 activation as well as *dependent* phosphorylation of p70 [ribosomal S6 kinase 1] are markedly elevated whereas Akt , participating in the classical pathway of mammalian target of rapamycin activation is not always activated . Regulation RPS6KA1 IL1B 10965886 728048 In addition , the MAP kinase-kinase MEK-1 and the ribosomal S6-kinase [RSK-1] are also phosphorylated in *response* to . Regulation RPS6KA1 IL1B 10965886 728065 IL-1beta and cAMP did not change the half-life of IGFBP-1 mRNA , but PD98059 and SB202190 , a p38 MAP kinase inhibitor , destabilized IGFBP-1 mRNA and blocked the phosphorylation of [RSK-1] in *response* to . Regulation RPS6KA3 EPHB2 17785202 1790527 We found that FGFR3 directly tyrosine phosphorylates the serine/threonine kinase p90RSK2 at Y529 , which consequently *regulates* [RSK2] activation by facilitating inactive binding to RSK2 that is required for ERK dependent phosphorylation and activation of RSK2 . Regulation RPS6KA5 EPHB2 17196532 1680520 Ca2+ -stimulated adenylyl cyclases regulate *dependent* activation of [MSK1] during fear conditioning . Regulation RPS6KA5 EPHB2 17397860 1735747 Since CREB is a downstream target of MSK-1 ( mitogen- and stress activated protein kinase-1 ) situated at the crossroad of ERK ( extracellular receptor kinase ) and p38MAPK signaling pathways , we reasoned that [MSK-1] could be a downstream molecular *target* for p38MAPK and signaling in the IPC hearts . Regulation RPS6KA5 TLR7 19922413 2190151 [MSK1] regulates the transcription of IL-1ra in *response* to activation in macrophages . Regulation RPS6KB1 EPHB2 12909616 1150823 Studies using specific inhibitors and dominant negative c-Raf expression in cardiomyocytes indicate that the [S6K1] activation *involves* mTOR , , and phosphatidylinositol 3-kinase pathways and is independent of protein kinase C and c-Raf . Regulation RPS6KB1 MAP2K6 12909616 1150830 Studies using specific inhibitors and dominant negative c-Raf expression in cardiomyocytes indicate that the [S6K1] activation *involves* mTOR , , and phosphatidylinositol 3-kinase pathways and is independent of protein kinase C and c-Raf . Regulation RPS6KB1 TNF 18952604 2001048 [S6K1] was phosphorylated at Thr-389 in *response* to . Regulation RPS6KB2 EPHB2 11431469 850015 Three different inhibitors of MEK1/2 abolished PE-induced activation of S6K2 whereas expression of constitutively active MEK1 activated S6K2 , without affecting the p38 mitogen activated protein kinase and JNK pathways , indicating that signaling *plays* a key role in regulation of [S6K2] by PE . Regulation RPS6KB2 MAP2K6 11431469 850010 *dependent* activation of [S6K2] in cardiomyocytes . Regulation RPS6KB2 MAP2K6 11431469 850021 Three different inhibitors of MEK1/2 abolished PE-induced activation of S6K2 whereas expression of constitutively active MEK1 activated S6K2 , without affecting the p38 mitogen activated protein kinase and JNK pathways , indicating that signaling *plays* a key role in regulation of [S6K2] by PE . Regulation RPS6KB2 MAP2K6 11431469 850031 Another hypertrophic agent , endothelin 1 , also activated [S6K2] in a *dependent* manner . Regulation RPS7 EPHB2 14563318 1154755 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS8 EPHB2 14563318 1154769 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPS9 EPHB2 14563318 1154783 [Ribosomal protein subunit (RPS)] synthesis was also *dependent* and increased to match rRNA production , but without evident increase in RPS mRNA . Regulation RPTOR CCND1 19225536 2054555 As [mTOR signaling] is activated in MCL and may *control* levels , we show that p53 activation may downregulate the AKT/mTOR pathway through a mechanism involving AMP kinase (AMPK) . Regulation RPTOR MAP2K6 21659537 2459579 Previous work indicated that [mTORC1] activation by the phorbol ester PMA ( phorbol 12-myristate 13-acetate ) depends upon PKCs and may *involve* . Regulation RRAS EDN2 18784646 2012158 Further , C3G over-expression enhanced the activation of [R-Ras] in *response* to . Regulation RRAS EPHB2 24439224 2901522 In addition , we investigated the intracellular signaling pathways in cervical cancer and found that [R-Ras] expression correlated positively with EphB2 in clinical samples , and its activity was *regulated* by in cervical cancer . Regulation RRN3 EPHB2 12620228 1066196 *dependent* phosphorylation of the transcription initiation factor [TIF-IA] is required for RNA polymerase I transcription and cell growth . Regulation RTN4R TNF 18524667 1922959 The nerve growth factor receptor p75 , a TNF family receptor , is absent or poorly expressed in certain types of neurons that respond to myelin inhibitors , thereby prompting speculation that other family receptors are *involved* in the [NgR1] complex . Regulation RUNX1 EPHB2 16368886 1539729 Here we show that the regulation of the immediate early gene X-1 (IEX-1) , identified as an ERK substrate in response to TPO , was mediated by an *dependent* phosphorylation of [AML1] . Regulation RUNX1 EPHB2 16368886 1539735 Taken together , these data suggest that AML1 plays a role in modulating the IEX-1 expression and that the *dependent* [AML1] phosphorylation regulates the TPO mediated activation of IEX-1 . Regulation RUNX1 TP63 18275068 1924782 Taken together our data demonstrate that directly *regulates* [Runx1] gene expression through a novel enhancer element and suggests a role for these two transcription factors in dictating skin keratinocyte and appendage development . Regulation RUNX2 EPHB2 11784711 922019 Superoxide mediates shock wave induction of *dependent* osteogenic transcription factor ( [CBFA1] ) and mesenchymal cell differentiation toward osteoprogenitors . Regulation RUNX2 EPHB2 20007706 2199909 We previously demonstrated that activation does not *affect* [Runx2] gene expression but that it stimulates Runx2 transcriptional activity . Regulation RUNX2 FOXO1 21471200 2433550 In this study , we determined the molecular mechanisms whereby forkhead transcription factor , a key downstream signaling molecule of insulin-like growth factor 1 (IGF1)/insulin actions , *regulates* [Runx2] activity and expression of the mouse osteocalcin gene 2 ( Bglap2 ) in osteoblasts in vitro . Regulation RUNX2 TNF 11723115 896995 We investigated the *effect* of the inflammatory cytokine on the expression of [RUNX2] because TNF is known to inhibit differentiation of osteoblasts from pluripotent progenitor cells . Regulation RUNX2 TNF 11723115 896996 The *effect* of on [RUNX2] gene transcription was evaluated using a 0.6-kb RUNX2 promoter-luciferase reporter in MC3T3-E1 cells . Regulation RUNX2 TNF 11723115 896998 Our results indicate that *regulates* [RUNX2] expression at multiple levels including destabilization of mRNA and suppression of transcription . Regulation RUNX2 TNF 15516323 1328534 We used RT-PCR to examine the *effects* of on bone sialoprotein ( BSP ) , [core binding factor a1 (Cbfa1)] , osterix , alpha 1 ( I ) collagen , cyclooxygenase-2 (COX-2) , interleukin-6 (IL-6) , cathepsin B , cathepsin L and tissue inhibitors of metalloproteinase-1 ( TIMP-1 ) . Regulation RUNX2 TNF 20638987 2292252 Of note , the inhibitory *effects* of on BMP-2 induced [Runx2] and osteocalcin expression were reversed by SAPK/JNK inhibition regardless of the presence of estradiol . Regulation RUNX3 CCND1 19351720 2064798 We analyzed the *effects* of on [Runx3] protein stability and function using COS cells , osteoprogenitor C3H10T1/2 cells and chondrogenic RCJ3.1C5.18 cells . Regulation RYK AXIN2 21814488 2462849 Third , [Ppa-LIN-18/Ryk] signaling *involves* and ß-catenin and Ppa-axl-1/Axin is epistatic to Ppa-lin-18/Ryk . Regulation RYR1 CAPN8 11148048 770499 These results demonstrate that the NH ( 2 ) -terminus of the RyR is a molecular target for dantrolene , and suggest a regulatory *role* for both activity and ATP in the interaction of dantrolene with the [RyR] in vivo . Regulation RYR2 CAPN8 11148048 770513 These results demonstrate that the NH ( 2 ) -terminus of the RyR is a molecular target for dantrolene , and suggest a regulatory *role* for both activity and ATP in the interaction of dantrolene with the [RyR] in vivo . Regulation RYR3 CAPN8 11148048 770527 These results demonstrate that the NH ( 2 ) -terminus of the RyR is a molecular target for dantrolene , and suggest a regulatory *role* for both activity and ATP in the interaction of dantrolene with the [RyR] in vivo . Regulation S100A11 S100B 10913138 743690 Using S100B as bait , we identify S100A6 and [S100A11] as specific *targets* for . Regulation S100A12 ADRB2 12651937 1072809 *regulation* of [CGRP] release from capsaicin-sensitive neurons . Regulation S100A12 EDN2 14653081 1173729 To investigate the plasma calcitonin gene related peptide (CGRP) and levels and the *effects* of nitroglycerin on [CGRP] and ET in congestive heart failure ( CHF ) , and to make clear the mechanism of nitroglycerin in vasodilation and cardiac protection . Regulation S100A12 EPHB2 21933441 2492267 The activation of spinal , p38 and CaMKII , alongside nNOS , is *involved* in chronic morphine induced [CGRP] up-regulation in both the DRG and SCDH . Regulation S100A12 IL1B 10934280 720435 The maximum *effect* reached almost 600 % of the heat evoked release , and the maximum TNF-alpha effect induced a rise in [CGRP] release of 350 % . Regulation S100A12 TNF 10934280 720434 The maximum IL-1 beta effect reached almost 600 % of the heat evoked release , and the maximum *effect* induced a rise in [CGRP] release of 350 % . Regulation S100A12 TNF 21057386 2376439 retrograde neurotracing and immunohistochemistry were used to investigate the *effect* of the inhibitor , etanercept , on [calcitonin gene related peptide (CGRP)] expression in dorsal root ganglion (DRG) neurons innervating intervertebral discs in rats . Regulation S100A12 TNF 21057386 2376441 *Effects* of inhibition on [CGRP] expression in DRG neurons were evaluated . Regulation S100A12 TNS1 2783612 106909 These results suggest that [CGRP] is involved in the induced vasodilator *response* of the large cerebral arteries of the cat . Regulation S100A2 EPHB2 22747445 2670197 *Regulation* of [S100A2] expression by TGF-ß induced signalling and its role in cell migration/invasion . Regulation S100A2 MAP2K6 22747445 2670203 *Regulation* of [S100A2] expression by TGF-ß induced signalling and its role in cell migration/invasion . Regulation S100A2 TP63 18388131 1913260 This may indicate a function of the *dependent* [S100A2] regulation in tumor suppression . Regulation S100A4 CTGF 17550972 1752627 Moreover , the cDNA microarray analysis revealed mediated *regulation* of the prometastatic gene [S100A4] . Regulation S100A4 STAT4 22740693 2659659 Collectively , we conclude that HBXIP up-regulates S100A4 through activating [S100A4] promoter *involving* and inducing PTEN/PI3K/AKT signaling to promote growth and migration of breast cancer cells . Regulation S100A6 AGR2 14585681 1159259 Intranasal immunizations of adult mice with strain 638 expressing [Ag2/PRA] induced serum vibriocidal antibody response to the vector strain and serum total IgG *response* to . Regulation S100A6 S100B 10913138 743691 Using S100B as bait , we identify [S100A6] and S100A11 as specific *targets* for . Regulation S100A6 TNF 12859951 1111014 These results suggest that NF-kappaB transcription factor contributes to the activation of [S100A6] gene expression in *response* to in HepG2 cells . Regulation S100A7 CTBP1 23000163 2689176 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Regulation S100A7 CTNNB1 18223693 1919129 More importantly , our results also indicated that signaling negatively *regulates* [S100A7] expression . Regulation S100A7 ESR2 17009105 1754523 *regulates* [psoriasin] ( S100A7 ) in human breast cancer . Regulation S100A7 ESR2 17009105 1754525 We have previously observed a paradoxical relationship of the psoriasin/S100A7 gene with estrogen response in-vitro in ERalpha positive cells but its association with ERalpha negative status in-vivo raising the possibility that [S100A7] might be *regulated* by in breast cancer . Regulation S100A7 ESR2 17009105 1754526 Using doxycycline-inducible ERbeta and ERalpha expressing MCF-7 cells the hypothesis that [psoriasin/S100A7] is *regulated* was investigated To explore the relationship between psoriasin/S100A7 and ERbeta expression in-vivo , we also assessed a cohort of 233 ERalpha negative breast tumors using tissue microarrays and immunohistochemistry . Regulation S100A7 ESR2 17009105 1754528 These data support the hypothesis that [psoriasin/S100A7] is specifically *regulated* by activity and could be useful to guide future therapies targeting ERbeta in certain phenotypic subsets of breast cancers in-vivo . Regulation S100A7 HDAC1 23000163 2689180 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Regulation S100A7 HMG20A 23000163 2689181 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Regulation S100A7 HMG20B 23000163 2689182 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Regulation S100A7 HSPA1B 23000163 2689183 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Regulation S100A7 IFNG 17986321 1835725 [S100A7] ( Psoriasin ) , highly expressed in ductal carcinoma in situ ( DCIS ) , is *regulated* by in mammary epithelial cells . Regulation S100A7 IFNG 17986321 1835726 We therefore examined the *effect* of and STAT signaling on the [psoriasin] expression . Regulation S100A7 KDM1A 23000163 2689179 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Regulation S100A7 PHF21A 23000163 2689175 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Regulation S100A7 PHF21B 23000163 2689177 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Regulation S100A7 RCOR1 23000163 2689174 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Regulation S100A7 RCOR3 23000163 2689178 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Regulation S100A7 RREB1 23000163 2689171 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Regulation S100A7 ZMYM2 23000163 2689172 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Regulation S100A7 ZNF217 23000163 2689173 Our data showed in vivo association of LSD1 with S100A7 promoters , confirming the potential *role* of in regulating [S100A7] expression . Regulation S100A8 SPHK1 21233411 2409052 These results define a pathway leading to NOX2 activation , in which p38 MAPK mediated [S100A8/A9] translocation is *regulated* by Ca ( 2+ ) store depletion dependent activation . Regulation S100A8 TNF 10779802 687526 IFN-gamma and *regulate* macrophage expression of the chemotactic S100 [protein S100A8] . Regulation S100A8 TNF 8384844 214881 and IFN-g did not *affect* [MRP8/MRP14] levels . Regulation S100A9 TNF 8384844 214883 and IFN-g did not *affect* [MRP8/MRP14] levels . Regulation S100B CA2 10493575 646672 Likewise , a 22 residue peptide derived from the C-terminal regulatory domain of p53 has been shown to interact with [S100B] ( beta beta ) in a *dependent* manner and inhibits its phosphorylation by PKC . Regulation S100B CA2 10876243 708886 A *dependent* conformational change in dimeric [S100B] ( betabeta ) is required for it to bind p53 and inhibit phosphorylation of this tumor suppressor in its C-terminal negative regulatory domain . Regulation S100B CA2 11402046 842941 Intracellular and Zn2+ levels *regulate* the alternative cell density dependent secretion of [S100B] in human glioblastoma cells . Regulation S100B CA2 12042313 968370 Using CacyBP/SIP affinity chromatography , we found that [S100B] from the brain extract binds to CacyBP/SIP in a *dependent* manner . Regulation S100B CA2 2736040 114575 Spectral studies of the *dependent* interaction of trifluoperazine with [S100b] . Regulation S100B CA2 6692927 35653 The *effect* on [S-100b] greater than S-100a was in agreement with our earlier CD observations . Regulation S100B CAV1 16551628 1555604 Here we report that non-receptor Src tyrosine kinase and the membrane protein *play* a key role in the activation of RAGE by [S100B] in VSMCs . Regulation S100B EPO 20505289 2263924 *Effect* of recombinant human on serum [S100B] protein and interleukin-6 levels after traumatic brain injury in the rat . Regulation S100B HES1 17923015 1804260 To observe the *effect* of 130/0.4 on [S100B] protein level and cerebral metabolism of oxygen in open cardiac surgery under cardiopulmonary bypass (CPB) and to explore whether it has the protective effect of 6 % HES130/0.4 as priming solution on cerebral injury during CPB and explore the probable mechanism . Regulation S100B HES2 17923015 1804255 To observe the *effect* of 130/0.4 on [S100B] protein level and cerebral metabolism of oxygen in open cardiac surgery under cardiopulmonary bypass (CPB) and to explore whether it has the protective effect of 6 % HES130/0.4 as priming solution on cerebral injury during CPB and explore the probable mechanism . Regulation S100B HES3 17923015 1804259 To observe the *effect* of 130/0.4 on [S100B] protein level and cerebral metabolism of oxygen in open cardiac surgery under cardiopulmonary bypass (CPB) and to explore whether it has the protective effect of 6 % HES130/0.4 as priming solution on cerebral injury during CPB and explore the probable mechanism . Regulation S100B HES4 17923015 1804258 To observe the *effect* of 130/0.4 on [S100B] protein level and cerebral metabolism of oxygen in open cardiac surgery under cardiopulmonary bypass (CPB) and to explore whether it has the protective effect of 6 % HES130/0.4 as priming solution on cerebral injury during CPB and explore the probable mechanism . Regulation S100B HES5 17923015 1804257 To observe the *effect* of 130/0.4 on [S100B] protein level and cerebral metabolism of oxygen in open cardiac surgery under cardiopulmonary bypass (CPB) and to explore whether it has the protective effect of 6 % HES130/0.4 as priming solution on cerebral injury during CPB and explore the probable mechanism . Regulation S100B HES6 17923015 1804256 To observe the *effect* of 130/0.4 on [S100B] protein level and cerebral metabolism of oxygen in open cardiac surgery under cardiopulmonary bypass (CPB) and to explore whether it has the protective effect of 6 % HES130/0.4 as priming solution on cerebral injury during CPB and explore the probable mechanism . Regulation S100B HES7 17923015 1804254 To observe the *effect* of 130/0.4 on [S100B] protein level and cerebral metabolism of oxygen in open cardiac surgery under cardiopulmonary bypass (CPB) and to explore whether it has the protective effect of 6 % HES130/0.4 as priming solution on cerebral injury during CPB and explore the probable mechanism . Regulation S100B HOXC11 21654685 2446290 *regulation* of [S100beta] in cutaneous melanoma : new targets for the kinase inhibitor dasatinib . Regulation S100B HTR1A 12468035 1022526 Astrocytic <5HT(1A)> receptors are *involved* in the plastic phenomena by releasing the astroglial derived neurotrophic factor [S-100beta] . Regulation S100B IL1A 16808851 1591307 However , the induction of chondroitin sulfate proteoglycans , tenascin , [S-100B] as well as glutamate transporter proteins , GLAST and GLT-1 , and glutamine synthetase are *independent* of signaling . Regulation S100B IL1B 19668572 2119446 We have also investigated the effect of amyloid beta peptide ( Abeta ) on APP in the same system and the *regulation* of [S100B] production by Abeta and from retinal glial cells . Regulation S100B MOK 15312903 1285304 Our data suggest that [S100B] secreted during the glial response to brain injury potently activates p65/c-Rel in a *dependent* manner and may exert neuroprotective and neuroregenerative effects in psychiatric disorders . Regulation S100B MOK 18599158 2208589 We show here that : ( 1 ) S100B also stimulates AP-1 transcriptional activity in microglia via *dependent* activation of JNK; (2) [S100B] upregulates IL-1beta and TNF-alpha expression in microglia via RAGE engagement ; Regulation S100B MOK 21570918 2480818 We show that expression of both RAGE and [S100B] are increased during EAMG and the interaction between and S100B *affected* the Th1/Th2/Th17/Treg cell equilibrium , up-regulate AChR-specific T cell proliferation . Regulation S100B NCALD 7887910 299060 These findings suggest that [S100 beta] is one of the target proteins of neurocalcin delta , and the beta complex may be *involved* in Ca ( 2+ ) -signalling in the glial cell . Regulation S100B NCOA1 21654685 2446291 *regulation* of [S100beta] in cutaneous melanoma : new targets for the kinase inhibitor dasatinib . Regulation S100B NTRK2 15968642 1440906 These data suggest that BDNF and cAMP , but not [S100beta] , rapidly induce both an up-regulation of the 5-HT neuronal phenotype and modifications of the neighboring astrocytes in a *dependent* manner . Regulation S100B PRL 23053124 2735284 We conclude that neither increased blood lactate nor serum *play* an exclusive role in the regulation of [S100B] . Regulation S100B TNF 16736247 1631461 *affects* the expression of GFAP and [S100B] : implications for Alzheimer 's disease . Regulation S100G ARSG 24324328 2880249 *regulates* the expression of [CaBP9k] and IL-4 receptor genes , and ORZ regulates the expression of the CaBP9k gene , while GABA at 100 mg/kg regulates the expression of the HSP70 gene . Regulation S100G IL1B 25049477 2718830 These results showed that [S100G] expression in the uterine endometrium was *regulated* by estrogen and of conceptus origin , and affected by the SCNT procedure during early pregnancy . Regulation S1PR1 F2R 15626732 1387908 Endothelial barrier protection by activated protein C through *dependent* [sphingosine 1-phosphate receptor-1] crossactivation . Regulation S1PR1 SNCAIP 12087059 959400 Recent studies have shown that in *response* to , [Edg-1] mediates various signaling pathways through downstream signaling molecules , such as MAP kinase and calcium , via heterotrimeric G-proteins . Regulation S1PR3 MBTPS1 18172856 1911119 The type 1 [S1P-R] ( S1P(1) ) is important for lymphocyte egress , and blood-borne as the natural ligand for S1P(1) is *involved* in the maintenance of lymphocyte circulation . Regulation S1PR3 MBTPS1 9409733 471503 When overexpressed in Jurkat cells , H218 and [Edg3] activated serum response element-driven transcriptional reporter gene in *response* to , dihydro-S1P and sphingosylphosphorylcholine , but not to LPA . Regulation S1PR3 S1PR1 23906789 2882374 Overall , these results reveal that TZDs not only modulate intracellular S1P levels but also *regulate* [S1PR] signaling by increasing expression in mesangial cells . Regulation SAA1 EPHB2 21701568 2505175 Moreover , SAA significantly increased porcine adipocyte glycerol release and lipase activity , which was inhibited by either ERK ( PD98059 ) or PKA ( H89 ) inhibitors , suggesting that and PKA were *involved* in mediating [SAA] enhanced lipolysis . Regulation SAA1 TNF 1651357 163082 alone had no significant *effect* on synthesis of either [SAA] or CRP , but the combination of IL-6 plus TNF-alpha led to substantial induction of SAA . Regulation SAA2 IL1B 15812237 1392221 While the NF-kappa B DNA binding site was essential for [SAA2] *regulation* by and deacetylase inhibitors , the C/EBP DNA binding site modulated SAA2 expression levels , as assessed by transient transfection assays and mutagenesis studies . Regulation SAA3P TNF 20444945 2275056 Thus , there appeared to be different mechanisms by which and cAMP *regulated* [SAA3] expression . Regulation SALL2 CTGF 21228219 2408996 TGFß repression of [SALL2] and AP4 is *independent* of the induction of by TGFß . Regulation SAMD9 TNF 18094730 1903366 We therefore assessed the *effect* of cellular stress and , a potent pro-inflammatory cytokine , on [SAMD9] gene expression . Regulation SAT1 TNF 16757480 1599112 Electromobility shift assays , chromatin immunoprecipitation experiments and mutational studies confirmed that two of the three NFkappaB response elements play an important role in the regulation of [SSAT] in *response* to . Regulation SCARB1 PDZK1 14551195 1175492 Here we show that *controls* in a tissue-specific and post-transcriptional fashion the expression of [SR-BI] in vivo . Regulation SCARB1 PDZK1 16867981 1613505 Here we show that the total plasma cholesterol levels and size distribution of lipoproteins are virtually identical in SR-BI ( -/- ) and SR-BI ( -/- ) /PDZK1 ( -/- ) mice , indicating that most , if not all of the effects of PDZK1 on lipoprotein metabolism are likely because of the *effects* of on [SR-BI] . Regulation SCARB1 PDZK1 23720744 2806794 The four PDZ ( PDZ1 to PDZ4 ) domain containing adaptor protein *controls* the expression , localization , and function of the HDL receptor [scavenger receptor class B] , type I ( SR-BI ) , in hepatocytes in vivo . Regulation SCARB1 PDZK1 23720744 2806799 Thus , PDZ4 may potentiate 's *regulation* of [SR-BI] by promoting its lipid mediated attachment to the cytoplasmic membrane . Regulation SCARB1 PDZK1 23936087 2826854 Challenges in using cultured primary rodent hepatocytes or cell lines to study hepatic HDL receptor [SR-BI] *regulation* by its cytoplasmic adaptor . Regulation SCARB1 PDZK1 23936087 2826855 Caution must be exercised in using primary hepatocytes or cultured cell lines when studying the mechanism underlying the *regulation* of hepatic [SR-BI] by . Regulation SCARB1 PLAU 24529115 2914881 The *effect* of on hepatic [SR-BI] expression was mediated via binding to the uPA receptor (uPAR) . Regulation SCARB2 PDZK1 23720744 2806795 The four PDZ ( PDZ1 to PDZ4 ) domain containing adaptor protein *controls* the expression , localization , and function of the HDL receptor [scavenger receptor class B] , type I ( SR-BI ) , in hepatocytes in vivo . Regulation SCD ADRB2 16618831 1551208 Our findings suggest that *plays* a role in [SCD] in humans . Regulation SCGB1A1 FOXA1 9545321 498558 Here , we show that the [uteroglobin/Clara] cell 10-kDa promoters from rabbit and man are *regulated* by and HNF3beta but not by HFH-4 and TTF-1 . Regulation SCGB3A1 IFNG 19135978 2032026 In this study , we examined the *effect* of on the expression of [SCGB3A1] which is thought to play crucial roles in inflammation and epithelial cell differentiation in lung . Regulation SCGB3A1 NFYA 18194566 1876243 *Regulation* of mouse [Scgb3a1] gene expression by and association of CpG methylation with its tissue-specific expression . Regulation SCGB3A1 NFYA 18194566 1876249 By reporter gene transfection and gel mobility shift analyses , we demonstrated that expression of the mouse [Scgb3a1] gene is *regulated* by a PU-box binding protein and a ubiquitous transcription factor that respectively binds to the PU-boxes located at -99 to -105 bp and -158 to -164 bp , and the `` CCAAT '' binding sites located at -425 to -429 bp and -498 to -502 bp from the transcription start site of the gene . Regulation SCGB3A1 NFYB 18194566 1876244 *Regulation* of mouse [Scgb3a1] gene expression by and association of CpG methylation with its tissue-specific expression . Regulation SCGB3A1 NFYB 18194566 1876250 By reporter gene transfection and gel mobility shift analyses , we demonstrated that expression of the mouse [Scgb3a1] gene is *regulated* by a PU-box binding protein and a ubiquitous transcription factor that respectively binds to the PU-boxes located at -99 to -105 bp and -158 to -164 bp , and the `` CCAAT '' binding sites located at -425 to -429 bp and -498 to -502 bp from the transcription start site of the gene . Regulation SCGB3A1 NFYC 18194566 1876245 *Regulation* of mouse [Scgb3a1] gene expression by and association of CpG methylation with its tissue-specific expression . Regulation SCGB3A1 NFYC 18194566 1876251 By reporter gene transfection and gel mobility shift analyses , we demonstrated that expression of the mouse [Scgb3a1] gene is *regulated* by a PU-box binding protein and a ubiquitous transcription factor that respectively binds to the PU-boxes located at -99 to -105 bp and -158 to -164 bp , and the `` CCAAT '' binding sites located at -425 to -429 bp and -498 to -502 bp from the transcription start site of the gene . Regulation SCGB3A1 OSM 18978304 2053307 Here we show that the expression of [SCGB3A1] and SCGB3A2 are bidirectionally *regulated* by when examined in a mouse transformed Clara cell line ( mtCC ) ; Regulation SCGB3A1 OSM 18978304 2053341 The differential *regulation* of [Scgb3a1] and Scgb3a2 gene expression by may explain the unique functions of these genes in the lung . Regulation SCNN1A IL1B 15755725 1403429 The inhibitory *effect* of on [alpha ENaC] expression was mediated by the activation of p38 MAPK in both rat and human ATII cells and was independent of the activation of alpha v beta6 integrin and transforming growth factor-beta . Regulation SCNN1A TNF 16877633 1638848 The potential *role* of and dexamethasone on [alphaENaC] promoter activity was tested in A549 alveolar epithelial cells . Regulation SCRIB EPHB2 20622900 2321776 The cell polarity regulator [hScrib] *controls* activation through a KIM site dependent interaction . Regulation SCT MAP2K6 11292597 800878 The *effect* of intravenous on acid stimulated [secretin] release and pancreatic exocrine secretion was then studied with or without coinfusion of naloxone , an anti-somatostatin (SS) serum , or normal rabbit serum . Regulation SDC1 IL1B 12200971 982986 The *effect* of on [syndecan-1] mRNA synthesis was partially reversed after adding PDGF-BB and TGF-beta 1 , separately or in combination , in the presence of IL-1 beta . Regulation SDC1 TNF 8702532 375478 The suppressive *effect* of on endothelial [syndecan-1] expression was reproducible in in vivo experiments in which TNF-alpha coated beads were administered directly to healing skin wounds of mice . Regulation SDC2 IL1B 12200971 982990 In contrast , [syndecan-2] mRNA level was markedly upregulated in *response* to either TGF-beta 1 or in OB when compared with the other two cell lines . Regulation SDC2 TNF 12840601 1113862 We examined whether IL-8 and *regulated* BM [HSPG] gene expression and HS synthesis in the glomerular epithelial cells ( GECs ) . Regulation SDC4 SPHK1 14705951 1196285 As [syndecan-4] signaling in leukocyte chemotaxis *involves* activation of , results indicate that naloxone interacts with syndecan-4 function in cell migration and suggest a role for heparan sulfate proteoglycans as coreceptors to members of the delta-opiate receptor family . Regulation SDC4 TNF 17545042 1751929 To investigate the *effects* of on [syndecan-4] protein expression and proliferation of cultured human umbilical vein endothelial-like cells ( HUVECs ) in vitro . Regulation SEA FAS 12373453 996545 When Fas-deficient ( C57BL/6 lpr/lpr ) or Fas ligand defective ( C57BL/6 gld/gld ) mice were treated with TCDD , they failed to exhibit a decrease in percentage and cellularity of SEA-reactive T cells , thereby suggesting a *role* of ligand interactions in the TCDD induced downregulation of [SEA-reactive] T cell response . Regulation SELE ANGPT1 11557733 861441 In the present study , we used human umbilical vascular endothelial cells ( HUVECs ) to examine the *effect* of on VEGF induced expression of three adhesion molecules : intercellular adhesion molecule-1 ( ICAM-1 ) , vascular cell adhesion molecule-1 ( VCAM-1 ) , and [E-selectin] . Regulation SELE FUT4 15579466 1368537 Here we have examined the *role* of human and -VII in conferring L-selectin , P-selectin , and [E-selectin] binding activities to PSGL-1 . Regulation SELE IL1B 19905948 2161808 A cytokine inactivation assay that measured [E-selectin] expression in *response* to TNF-alpha and was developed to measure the ability of aPDT to inactivate cytokine function . Regulation SELE IL1B 20540094 2308246 The effectiveness of 2 , 3 DSH to down *regulate* [E-selectin] and key proinflammatory cytokines ( and IL-6 ) was assessed by western blot and immunocytochemistry . Regulation SELE IL1B 8921195 396719 The *effects* of , TNF alpha , LPS , and an LPS conditioned plasma product on [E-selectin] expression were characterized . Regulation SELE IL1B 9500526 490801 Utilizing neutralizing antibodies , we show that CD40L mediated tissue factor and thrombomodulin modulation , as well as [E-selectin] and VCAM-1 upregulation , is *independent* of tumor necrosis factor alpha , interleukin-1alpha , or production . Regulation SELE LY6D 10777581 686875 The GPI linked Ly-6 antigen *regulates* expression levels of the FX enzyme and of [E-selectin] ligands on head and neck squamous carcinoma cells . Regulation SELE PECAM1 7722414 301824 Antibody blocking studies of the ligands on HUVE indicated that [E-selectin] may be partially involved in this CD18 independent PMNL migration but that ICAM-1 , VCAM-1 , , and P-selectin are not *involved* . Regulation SELE PECAM1 9538126 497605 [ELAM] expression was *independent* of Ki-67/MIB1 , anti-P53 and anti-Bcl2 , anti-CD44v , anti-c-erbB-2 , , anti-RE/RP , anti-PS2 , and anti-VLA3 immunoreactions . Regulation SELE TNF 10030794 591785 *Role* of and interferon gamma in endotoxin induced [E-selectin] expression . Regulation SELE TNF 10195917 604205 [E-selectin] expression in *response* to was , as expected , inhibited in ECs that had been preincubated with HDLs . Regulation SELE TNF 10466115 640658 Characterization of the isolated cultures included expression of endothelial cell markers , regulation of [E-selectin] in *response* to , proliferative response to angiogenic growth factors , and expression of progesterone and estrogen receptors . Regulation SELE TNF 10466115 640660 HEEC also upregulated [E-selectin] in *response* to in a manner similar to that seen for other endothelial cell types . Regulation SELE TNF 10638837 576814 Significant differences were found in the ability to respond to cytokines between HUVEC and the cell lines , the greatest differences being induction of VCAM-1 and [E-selectin] in *response* to and induction of MHC class II antigens in response to IFN-gamma . Regulation SELE TNF 10964678 727872 Peroxisome proliferator activated receptor ( PPAR ) activators were shown to inhibit the expression of [E-selectin] of human vascular endothelial cells in *response* to . Regulation SELE TNF 11678640 873686 induced the expression of E-selectin on all three kinds of endothelial cells , but IFN-gamma had no *effect* on [E-selectin] expression . Regulation SELE TNF 12514595 1039166 Fluid flow inhibited [E-selectin] protein levels by about 50 % in *response* to but had no effect on total E-selectin messenger RNA ( mRNA ) expression . Regulation SELE TNF 12514595 1039168 Although fluid flow did not reduce total cellular [E-selectin] mRNA levels in *response* to , the amount of E-selectin mRNA present in the actively translated polysome fraction was markedly attenuated . Regulation SELE TNF 1381227 196040 The present study aimed to see whether TNF induction of [ELAM-1] and ICAM-1 on human umbilical vein endothelial cells ( HUVECs ) *involved* novel interactions . Regulation SELE TNF 1382639 198299 Exposure of HUVEC to perflubron did not alter the up-regulation of ICAM or [ELAM] in *response* to IL-1 or ( n = 20 ) . Regulation SELE TNF 14565715 1154955 HPVEC express [E-selectin] , ICAM-1 , and VCAM-1 in *response* to the inflammatory cytokine similarly to other types of cultured human endothelial cells . Regulation SELE TNF 16806337 1585957 E2 significantly attenuated the *effects* of on ERK1/2 activity , apoptosis , and [E-selectin] expression in the cells . Regulation SELE TNF 18471997 1916662 Transfection in human aorta endothelial cells ( HAECs ) with these constructs revealed that the [E-selectin] promoter was sufficiently activated in *response* to , and miR-E1 and miR-E2 could suppress E-selectin expression resulting in the significant inhibition of leukocyte adhesion . Regulation SELE TNF 19238330 2093606 The cells showed constitutive activation as evidenced by the induction of basal VCAM-1 expression , and further showed a more augmented VCAM-1 and [E selectin] *response* to compared with empty vector control cells ( EC ( EV ) ) . Regulation SELE TNF 19878508 2293560 The objectives of this study were to : ( 1 ) determine the body composition , metabolic and inflammatory factors associated with increased E-selectin and ( 2 ) determine the *role* of in the physiological regulation of [E-selectin] by antagonism of TNF-alpha with etanercept among obese subjects . Regulation SELE TNF 19878508 2293562 TNF-alpha antagonism with etanercept reduces E-selectin in obese subjects , providing evidence that the systemic circulatory release of [E-selectin] is *regulated* at least in part by in obesity . Regulation SELE TNF 19905948 2161807 A cytokine inactivation assay that measured [E-selectin] expression in *response* to and IL-1 beta was developed to measure the ability of aPDT to inactivate cytokine function . Regulation SELE TNF 20181103 2222763 This correlates with increased translocation of the transcription factor NF-kB to the nucleus , which is known to regulate ICAM-1 , VCAM-1 and [E-selectin] expression in *response* to . Regulation SELE TNF 23929007 2840714 Ectopic expression of aB-crystallin in endothelial cells increases the level of [E-selectin] expression in *response* to , and enhances leukocyte-endothelial interaction in vitro . Regulation SELE TNF 7518452 261869 We now show that cAMP decreases the [ELAM-1] promoter *response* to in transient transfection assays in bovine aortic endothelial cells and that cAMP mediated inhibition maps to the CRE/ATF element . Regulation SELE TNF 7518452 261870 Our data suggest that a change in the composition of the proteins binding to the CRE/ATF promoter element contributes to the competing *effects* of and cAMP on [ELAM-1] gene expression . Regulation SELE TNF 7521751 243711 In contrast to the observed reduction of VCAM-1 mRNA accumulation and surface protein expression , inhibition of topoisomerase II activity enhanced [E-selectin] mRNA accumulation and surface protein expression in *response* to stimulation of HUVE . Regulation SELE TNF 7578984 333396 The current study was undertaken to investigate the *role* of in regulation of [E-selectin] and ICAM-1 expression by TNF on HUVEC . Regulation SELE TNF 7691889 231027 In a distinct pattern , PDTC partially inhibited [E-selectin] gene expression in *response* to but not to LPS , IL-1 beta , or PIC . Regulation SELE TNF 7691964 231057 These results with DMEC differ from human umbilical vein EC analyzed in parallel , which are completely CD36- and show transient [ELAM-1] and sustained VCAM-1 expression in *response* to and IL-1 . Regulation SELE TNF 8100455 222542 Exposure of HUVEC to perflubron did not alter the upregulation of ICAM or [ELAM] in *response* to IL-1 or ( n = 20 ) . Regulation SELE TNF 8386742 217837 This finding correlated with the exclusive activity of TNF-R55 in the *dependent* regulation of the expression of the intercellular adhesion molecule type 1 ( ICAM-1 ) , [E-selectin] , and vascular cell adhesion molecule type 1 ( VCAM-1 ) . Regulation SELE TNF 8568264 350975 The TNF induced expression of VCAM-1 and [E-selectin] was found to be exclusively *controlled* by the 55-kDa ( TNFRp55 ) as demonstrated by analysis of TNFRp55-/- mice . Regulation SELE TNF 8729095 373992 In further studies , DHA dose- and time-dependently reduced also the expression of [E-selectin] , Intercellular Adhesion Molecule-1 , interleukin (IL)-6 and IL-8 , in *response* to IL-1 , IL-4 , , or bacterial endotoxin . Regulation SELE TNF 9006914 410764 Transcriptional *regulation* of the [E-selectin] promoter by requires multiple nuclear factor-kappaB (NF-kappaB) binding sites and a cAMP-responsive element/activating transcription factor-like binding site designated positive domain II ( PDII ) . Regulation SELE TNF 9351830 466079 Microinjection of the inhibitory peptides into stimulated cells abolished NF-kappa B activation in *response* to and the consequent expression of [E-selectin] , an NF-kappa B-dependent cell-adhesion molecule . Regulation SELE TNF 9632524 512701 Among them , [E-selectin] , which is expressed in *response* to interleukin 1 (IL-1) or , provides rolling adhesion of the circulating leukocytes , a transient and reversible interaction that initiates leukocyte extravasation . Regulation SELL ABL1 21277237 2398198 *Role* of in [L-selectin] shedding from the neutrophil surface . Regulation SELL ANG 19837408 2224671 The present work was undertaken to investigate whether *regulates* the expression of [CD62L] on human neutrophils . Regulation SELL ANPEP 9824771 549167 CD10 , CD11b , CD11c , , CD18 , CD35 , CD45 , CD66acde , and CD66b were upregulated at 15 min and remained upregulated at 180 min . CD61 and CD63 increased slightly at 15 min and returned to baseline by 180 min . CD16 and [CD62L] were down *regulated* at 15 min and normalized by 180 min. CD15s , CDw17 , CD32 , and CD44 were slightly down regulated at 15 min and then returned to baseline by 180 min . CD11a , CD15 , CD24 , CD31 , and CDw65 did not change during dialysis . Regulation SELL APOB 7538217 301270 *Effects* of modified low density and hypoxia on the expression of endothelial [leukocyte adhesion molecule-1] . Regulation SELL C5 1279509 202988 Eosinophil expression of [L-selectin] decreased modestly after stimulation with platelet activating factor , but was minimally *affected* by N-formyl-methionyl-leucyl-phenylalanine , leukotriene B4 , or compared with their effects on neutrophils . Regulation SELL CA2 8660298 358825 It is known that [L-selectin] binds to glycoconjugates containing the tetrasaccharide sialyl Lewis X in a *dependent* manner . Regulation SELL CA2 8892633 392134 [L-selectin] binding to PSGL-1 is specific since it was blocked by Abs to L-selectin or PSGL-1 , required appropriate glycosylation of PSGL-1 , and was *dependent* . Regulation SELL CALM3 12167449 973117 To elucidate the mechanisms involved in the action of new macrolides on chronic sinusitis , we examined the *effects* of and roxiythromycin ( RXM ) on the expression of adhesion molecules ( [L-selectin] and Mac-1 ) on peripheral blood neutrophils of individuals with chronic sinusitis . Regulation SELL CALM3 22711531 2638884 Structural insights into *regulated* [L-selectin] ectodomain shedding . Regulation SELL CALM3 9529256 496577 *regulates* [L-selectin] adhesion molecule expression and function through a protease dependent mechanism . Regulation SELL CALM3 9529256 496578 The *effects* of the inhibitors on [L-selectin] expression and function can be prevented by cotreatment with a hydroxamic acid based metalloprotease inhibitor . Regulation SELL CBL 11263968 796489 Therefore , the adapter protein *plays* a role in [L-selectin] signaling and might modulate immune function by the specific recruitment of signaling molecules to multiprotein complexes . Regulation SELL CCL2 1348518 182831 In this study , immunofluorescence flow cytometry was used to determine whether can *regulate* the cell surface expression of adhesion molecules , particularly beta-2 and alpha-4 integrins and the [leukocyte adhesion molecule-1] . Regulation SELL CD8A 2482844 124202 In contrast , cell loss did preferentially *affect* [Leu 8-] , CD45R- , and HLA-DR+ CD8 subsets , compared to the reciprocal CD8 subsets . Regulation SELL CD8B 2482844 124203 In contrast , cell loss did preferentially *affect* [Leu 8-] , CD45R- , and HLA-DR+ CD8 subsets , compared to the reciprocal CD8 subsets . Regulation SELL CEACAM8 9824771 549166 CD10 , CD11b , CD11c , CD13 , CD18 , CD35 , CD45 , CD66acde , and were upregulated at 15 min and remained upregulated at 180 min . CD61 and CD63 increased slightly at 15 min and returned to baseline by 180 min . CD16 and [CD62L] were down *regulated* at 15 min and normalized by 180 min. CD15s , CDw17 , CD32 , and CD44 were slightly down regulated at 15 min and then returned to baseline by 180 min . CD11a , CD15 , CD24 , CD31 , and CDw65 did not change during dialysis . Regulation SELL CNTN2 7579405 325403 To understand the mechanism of leukemic cell infiltration into organs , we studied the expression and regulation of L-selectin mRNA in fresh leukemic cells of adult T-cell leukemia (ATL) patients and investigated the *response* of the [L-selectin] promoter to human T-cell lymphotropic virus type 1 ( HTLV-1 ) , which is a viral transcriptional transactivator . Regulation SELL CSF2 1694883 135323 Granulocyte-macrophage and other cytokines *regulate* surface expression of the [leukocyte adhesion molecule-1] on human neutrophils , monocytes , and their precursors . Regulation SELL CSF2 1694883 135327 Interestingly , and IFN-gamma had minimal *effects* on neutrophil [LAM-1] expression . Regulation SELL CSF2 7692935 231196 To further explore the possible role of G-CSF in inflammation we studied the *effect* of on the surface expression of [LAM-1] on human neutrophils , both in vitro and in vivo . Regulation SELL EDN1 9373765 464803 In addition , we investigated the *effects* of on expression of the leucocyte adhesion molecules CD11b/CD18 and [L-selectin] on monocytes and neutrophils . Regulation SELL FOXO1 18713968 1950750 *regulates* [L-Selectin] and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase . Regulation SELL FOXO1 18713968 1950751 We now report that *controls* the expression of [L-selectin] , an essential homing molecule , in human T lymphocytes . Regulation SELL FOXO1 23133314 2696557 We conclude that *regulates* [L-selectin] expression through targeting its promoter . Regulation SELL FUT4 11485743 844908 These observations reveal essential *dependent* contributions to E- , P- , and [L-selectin] ligand synthesis and to the control of leukocyte recruitment and lymphocyte homing . Regulation SELL FUT4 14597733 1160943 Intravital microscopy experiments revealed that MECA-79-reactive ligands depend primarily on FucT-VII , whereas MECA-79 independent medullary [L-selectin] ligands are *regulated* by . Regulation SELL FUT4 15579466 1368539 Here we have examined the *role* of human and -VII in conferring [L-selectin] , P-selectin , and E-selectin binding activities to PSGL-1 . Regulation SELL FUT7 15579466 1368540 Here we have examined the *role* of human in conferring [L-selectin] , P-selectin , and E-selectin binding activities to PSGL-1 . Regulation SELL HES1 16247329 1471562 The *effect* of on PMN surface expression of CD11b and [L-selectin] was measured by flow cytometry . Regulation SELL HES2 16247329 1471557 The *effect* of on PMN surface expression of CD11b and [L-selectin] was measured by flow cytometry . Regulation SELL HES3 16247329 1471561 The *effect* of on PMN surface expression of CD11b and [L-selectin] was measured by flow cytometry . Regulation SELL HES4 16247329 1471560 The *effect* of on PMN surface expression of CD11b and [L-selectin] was measured by flow cytometry . Regulation SELL HES5 16247329 1471559 The *effect* of on PMN surface expression of CD11b and [L-selectin] was measured by flow cytometry . Regulation SELL HES6 16247329 1471558 The *effect* of on PMN surface expression of CD11b and [L-selectin] was measured by flow cytometry . Regulation SELL HES7 16247329 1471556 The *effect* of on PMN surface expression of CD11b and [L-selectin] was measured by flow cytometry . Regulation SELL IFNG 1694883 135328 Interestingly , granulocyte-CSF and had minimal *effects* on neutrophil [LAM-1] expression . Regulation SELL IL10 11230988 789439 The *effect* of on the expression of monocyte adhesion molecules ( CD18 and [CD62-L] ) was studied by flow cytometry . Regulation SELL IL10 19489247 2091265 To investigate the inhibiting *effects* of on the expression of E-selectin and [L-selectin] in cerebral ischemia-reperfusions . Regulation SELL IL10 9647249 514976 NK activation by PMA , IL-2 , IL-15 , or TGF-beta down-regulated L-selectin on the CD56bright subset , while increased [L-selectin] levels were observed in both the CD56bright and CD56dim NK subsets in *response* to IL-12 , , or IFN-alpha . Regulation SELL IL12A 10415016 631141 Expression of [L-selectin] on Th1 cells is *regulated* by . Regulation SELL IL12A 10415016 631145 Given the key role played by IL-12 in the differentiation of naïve T cells into the Th1 subset , the observation that can also *regulate* [L-selectin] expression has implications for the migration of Th1 effector cells both through the lymphatic system and to sites of inflammation . Regulation SELL IL12A 9647249 514977 NK activation by PMA , IL-2 , IL-15 , or TGF-beta down-regulated L-selectin on the CD56bright subset , while increased [L-selectin] levels were observed in both the CD56bright and CD56dim NK subsets in *response* to , IL-10 , or IFN-alpha . Regulation SELL IL12B 10415016 631142 Expression of [L-selectin] on Th1 cells is *regulated* by . Regulation SELL IL12B 10415016 631146 Given the key role played by IL-12 in the differentiation of naïve T cells into the Th1 subset , the observation that can also *regulate* [L-selectin] expression has implications for the migration of Th1 effector cells both through the lymphatic system and to sites of inflammation . Regulation SELL IL12B 9647249 514978 NK activation by PMA , IL-2 , IL-15 , or TGF-beta down-regulated L-selectin on the CD56bright subset , while increased [L-selectin] levels were observed in both the CD56bright and CD56dim NK subsets in *response* to , IL-10 , or IFN-alpha . Regulation SELL IL25 16792588 1578776 Our findings suggest an essential *role* of in enhancing survival and regulating surface expression of ICAM-1 , ICAM-3 and [L-selectin] on human eosinophils through the activation of p38 MAPK , JNK and nuclear factor (NF)-kappaB pathways , thereby shedding light on the molecular mechanisms of IL-25 induced eosinophilia in allergic inflammation . Regulation SELL IL4 1372287 182952 The inhibitory *effect* of on enhanced [LECAM-1] expression was reversible , and characterized all 3 LECAM-1 epitopes assessed . Regulation SELL IL4 1372287 182954 Natural killer cells , in contrast , did not exhibit CAE of LECAM-1 expression , and had no modulatory *effect* on [LECAM-1] expression by these cells . Regulation SELL IL6 12181114 977437 The *effect* of on [L-selectin] levels on polymorphonuclear leukocytes . Regulation SELL IL6 12181114 977438 The present study was designed to determine the *effect* of on [L-selectin] levels of PMN in rabbits . Regulation SELL IL7 20831893 2346445 Cdc25A-driven proliferation regulates [CD62L] levels and lymphocyte movement in *response* to . Regulation SELL ITGB2 21972294 2512699 We determined that this change was due to a specific enrichment of activated , graft-specific effectors in the peripheral lymph nodes of anti-LFA-1 treated mice compared with untreated controls , and not to a direct *effect* of on [CD62L] expression . Regulation SELL ITGB2 9824771 549168 CD10 , CD11b , CD11c , CD13 , , CD35 , CD45 , CD66acde , and CD66b were upregulated at 15 min and remained upregulated at 180 min . CD61 and CD63 increased slightly at 15 min and returned to baseline by 180 min . CD16 and [CD62L] were down *regulated* at 15 min and normalized by 180 min. CD15s , CDw17 , CD32 , and CD44 were slightly down regulated at 15 min and then returned to baseline by 180 min . CD11a , CD15 , CD24 , CD31 , and CDw65 did not change during dialysis . Regulation SELL LCK 18653462 1967074 Critical *role* of in [L-selectin] signaling induced by sulfatides engagement . Regulation SELL LCK 18653462 1967076 These results suggest that *plays* a critical role in [L-selectin] signaling upon sulfatides stimulation . Regulation SELL LPA 7538217 301271 *Effects* of modified low density and hypoxia on the expression of endothelial [leukocyte adhesion molecule-1] . Regulation SELL MAPK1 10748078 690776 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Regulation SELL MAPK1 20331435 2254938 The cytoplasmic domains of TNFalpha converting enzyme ( TACE/ADAM17 ) and [L-selectin] are *regulated* differently by p38 and PKC to promote ectodomain shedding . Regulation SELL MAPK10 10748078 690777 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Regulation SELL MAPK10 20331435 2254939 The cytoplasmic domains of TNFalpha converting enzyme ( TACE/ADAM17 ) and [L-selectin] are *regulated* differently by p38 and PKC to promote ectodomain shedding . Regulation SELL MAPK11 10748078 690778 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Regulation SELL MAPK11 20331435 2254940 The cytoplasmic domains of TNFalpha converting enzyme ( TACE/ADAM17 ) and [L-selectin] are *regulated* differently by p38 and PKC to promote ectodomain shedding . Regulation SELL MAPK12 10748078 690779 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Regulation SELL MAPK12 20331435 2254941 The cytoplasmic domains of TNFalpha converting enzyme ( TACE/ADAM17 ) and [L-selectin] are *regulated* differently by p38 and PKC to promote ectodomain shedding . Regulation SELL MAPK13 10748078 690780 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Regulation SELL MAPK13 20331435 2254942 The cytoplasmic domains of TNFalpha converting enzyme ( TACE/ADAM17 ) and [L-selectin] are *regulated* differently by p38 and PKC to promote ectodomain shedding . Regulation SELL MAPK14 10748078 690781 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Regulation SELL MAPK14 20331435 2254943 The cytoplasmic domains of TNFalpha converting enzyme ( TACE/ADAM17 ) and [L-selectin] are *regulated* differently by p38 and PKC to promote ectodomain shedding . Regulation SELL MAPK15 10748078 690775 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Regulation SELL MAPK15 20331435 2254937 The cytoplasmic domains of TNFalpha converting enzyme ( TACE/ADAM17 ) and [L-selectin] are *regulated* differently by p38 and PKC to promote ectodomain shedding . Regulation SELL MAPK3 10748078 690782 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Regulation SELL MAPK3 20331435 2254944 The cytoplasmic domains of TNFalpha converting enzyme ( TACE/ADAM17 ) and [L-selectin] are *regulated* differently by p38 and PKC to promote ectodomain shedding . Regulation SELL MAPK4 10748078 690783 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Regulation SELL MAPK4 20331435 2254945 The cytoplasmic domains of TNFalpha converting enzyme ( TACE/ADAM17 ) and [L-selectin] are *regulated* differently by p38 and PKC to promote ectodomain shedding . Regulation SELL MAPK6 10748078 690784 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Regulation SELL MAPK6 20331435 2254946 The cytoplasmic domains of TNFalpha converting enzyme ( TACE/ADAM17 ) and [L-selectin] are *regulated* differently by p38 and PKC to promote ectodomain shedding . Regulation SELL MAPK7 10748078 690785 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Regulation SELL MAPK7 20331435 2254947 The cytoplasmic domains of TNFalpha converting enzyme ( TACE/ADAM17 ) and [L-selectin] are *regulated* differently by p38 and PKC to promote ectodomain shedding . Regulation SELL MAPK8 10748078 690786 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Regulation SELL MAPK8 20331435 2254948 The cytoplasmic domains of TNFalpha converting enzyme ( TACE/ADAM17 ) and [L-selectin] are *regulated* differently by p38 and PKC to promote ectodomain shedding . Regulation SELL MAPK9 10748078 690787 [L-selectin] signaling of neutrophil adhesion and degranulation *involves* p38 . Regulation SELL MAPK9 20331435 2254949 The cytoplasmic domains of TNFalpha converting enzyme ( TACE/ADAM17 ) and [L-selectin] are *regulated* differently by p38 and PKC to promote ectodomain shedding . Regulation SELL MGAT1 11490014 845576 Our data show that endothelial [L-selectin] ligands relevant for rolling in inflamed microvessels of the cremaster muscle are completely *dependent* . Regulation SELL MMP1 8662605 365018 Recombinant human ( MMP1 ) reduced the number of L-selectin positive lymphocytes to a similar extent as phorbol ester activation , and stromelysin ( MMP3 ) had a partial *effect* on [L-selectin] expression . Regulation SELL MTOR 18802080 1964537 CCR5 , CCR7 , and [CD62L] expression was not *affected* by inhibition , which allowed for DC-R in vivo trafficking to secondary lymphoid compartments where immunregulation is required . Regulation SELL MYD88 11842086 929195 We show that HSP70 induces interleukin-12 (IL-12) and endothelial [cell-leukocyte adhesion molecule-1] ( ELAM-1 ) promoters in macrophages and that this is *controlled* by and TRAF6 . Regulation SELL NA 15845704 1398901 We investigated the *effect* of on the expression of CD11b and [CD62L] in endotoxin stimulated human whole blood . Regulation SELL NA 15845704 1398904 However , did not *affect* the LPS induced downregulation of [CD62L] . Regulation SELL PIK3CA 20564190 2285232 is *involved* in [L-selectin-] and PSGL-1 mediated neutrophil rolling on E-selectin via F-actin redistribution and assembly . Regulation SELL PIK3R1 20564190 2285233 is *involved* in [L-selectin-] and PSGL-1 mediated neutrophil rolling on E-selectin via F-actin redistribution and assembly . Regulation SELL PTPRC 9824771 549169 CD10 , CD11b , CD11c , CD13 , CD18 , CD35 , , CD66acde , and CD66b were upregulated at 15 min and remained upregulated at 180 min . CD61 and CD63 increased slightly at 15 min and returned to baseline by 180 min . CD16 and [CD62L] were down *regulated* at 15 min and normalized by 180 min. CD15s , CDw17 , CD32 , and CD44 were slightly down regulated at 15 min and then returned to baseline by 180 min . CD11a , CD15 , CD24 , CD31 , and CDw65 did not change during dialysis . Regulation SELL PTX3 24387024 903798 Abstract We investigated the *effects* of on the expression of [L-selectin] on polymorphonuclear leukocytes ( PMN ) . Regulation SELL PTX4 24387024 903797 Abstract We investigated the *effects* of on the expression of [L-selectin] on polymorphonuclear leukocytes ( PMN ) . Regulation SELL SELP 10202042 605968 These modified proteins , sCR1sLex and sCR1 [ desLHR-A ] sLex , were assessed in the L-selectin- and *dependent* rat model of lung injury following systemic activation of complement by cobra venom factor and in the [L-selectin-] , P-selectin- , and E-selectin dependent model of lung injury following intrapulmonary deposition of IgG immune complexes . Regulation SELL SELPLG 23657464 2827814 P-selectin glycoprotein-1 (PSGL-1) antibody also ameliorated skin inflammation , and basophils were bound to [L-selectin] in a *dependent* manner , which was regulated by FT-IV/VII . Regulation SELL SMURF1 21382345 2411714 Consequently , represses the transcriptional factor activity of KLF2 and *regulates* the expression its downstream genes such as [CD62L] and Wee1 . Regulation SELL TIMP1 8662605 365019 Lymphocytes did not express fibroblast collagenase or stromelysin at the cell surface , and tissue inhibitor of metalloproteinases ( ) did not *affect* [L-selectin] levels . Regulation SELL TNF 10480607 643528 These purified human islet MVEC ( HI-MVEC ) express von Willebrand factor , take up high levels of acetylated LDL , and upregulate endothelial cell [leukocyte adhesion molecule 1] in *response* to . Regulation SELL TNF 12847490 1109000 In addition , the *effect* of on [endothelial-leukocyte adhesion molecule 1] and vascular cell adhesion molecule 1 expression by means of Western blot analysis was compatible with the mRNA results . Regulation SELL TNF 21237580 2397724 The study results indicate that the primary pro-inflammatory cytokine *regulates* the [L-selectin] surface expression on PMN after surgical trauma . Regulation SELL TRAF6 11842086 929194 We show that HSP70 induces interleukin-12 (IL-12) and endothelial [cell-leukocyte adhesion molecule-1] ( ELAM-1 ) promoters in macrophages and that this is *controlled* by MyD88 and . Regulation SELL UTP15 8600168 351819 , ADP , and adenosine ( all at 500 microM ) had no *effect* on [L-selectin] expression . Regulation SELL UTP18 8600168 351817 , ADP , and adenosine ( all at 500 microM ) had no *effect* on [L-selectin] expression . Regulation SELL UTP20 8600168 351815 , ADP , and adenosine ( all at 500 microM ) had no *effect* on [L-selectin] expression . Regulation SELL UTP23 8600168 351820 , ADP , and adenosine ( all at 500 microM ) had no *effect* on [L-selectin] expression . Regulation SELL UTP3 8600168 351818 , ADP , and adenosine ( all at 500 microM ) had no *effect* on [L-selectin] expression . Regulation SELL UTP6 8600168 351816 , ADP , and adenosine ( all at 500 microM ) had no *effect* on [L-selectin] expression . Regulation SELP CAPN8 15985533 1428623 We observed a smoke extract induced , *dependent* degradation of the intracellular form of platelet-endothelial cell adhesion molecule 1/CD31 , as well as a release of [P-selectin/CD62P] , IL-6 , and IL-8 from endothelial cells into the supernatant . Regulation SELP F2R 12632022 1067925 In summary , Ca(II)3 ( 3,5-DIPS ) 6 , a new calmodulin dependent nitric oxide synthase activator , decreases [P-selectin] expression of human platelets in *response* to activation . Regulation SELP F2R 20180904 2272420 These results suggest a physiologic role for the low concentration of thrombin in maintaining the integrity of the EPCR containing vasculature through the *dependent* inhibition of Ang2 and [P-selectin] release from Weibel-Palade bodies . Regulation SELP F2R 23340049 2769787 The vasodilator stimulated phosphoprotein ( VASP ) phosphorylation assay , multiple electrode aggregometry (MEA) with adenosine diphosphate ( ADP ) , and surface expressions of [P-selectin] and activated glycoprotein (GP) IIb/IIIa in *response* to ADP and activating peptide ( TRAP ) -6 were assessed in 71 obese and 245 nonobese patients . Regulation SELP FUT4 15579466 1368541 Here we have examined the *role* of human and -VII in conferring L-selectin , [P-selectin] , and E-selectin binding activities to PSGL-1 . Regulation SELP HES2 16247329 1471571 The *effect* of on endothelial cell surface expression of E-selectin , [P-selectin] , vascular cell adhesion molecule-1 ( VCAM-1 ) , and intracellular adhesion molecule-1 ( ICAM-1 ) was evaluated by enzyme linked immunoabsorbant assay . Regulation SELP HES2 16247329 1471627 After stimulation with IL-1 ( 10 U/mL ) , had no *effect* on the expression of [P-selectin] , E-selectin , ICAM-1 , or VCAM-1 . Regulation SELP IL1B 10868655 706554 To identify possible mediators , the *effects* of tumor necrosis factor-alpha and on [GMP-140] expression in primary sinusoidal endothelial cells were analyzed . Regulation SELP SELL 8909556 394519 is not *involved* in direct binding to either E- or [P-selectin] and is not a major counterreceptor of endothelial selectins . Regulation SELP TNF 10868655 706553 To identify possible mediators , the *effects* of and interleukin-1beta on [GMP-140] expression in primary sinusoidal endothelial cells were analyzed . Regulation SELP TNF 21981016 2547164 We investigated how expression of ICAM-1 , VCAM-1 , MAdCAM-1 , PECAM-1 , E- and [P-selectin] in *response* to , IL-1ß and IFN-? was altered by aglycemia ( A ) , hypoxia ( H ) or combined oxygen glucose deprivation ( OGD ) . Regulation SELP TNF 7537962 301096 *Regulation* of [P-selectin] by . Regulation SELPLG CD14 9198171 438598 Tissue factor upregulation on monocytes is mediated by [PSGL-1] and is *independent* of , the LPS receptor . Regulation SEPP1 ARSA 10624784 576199 The *effects* of on [somatosensory evoked potentials (SEP)] and neural levels of thiobarbituric acid reactive substances ( TBARS ) , products of lipid peroxidation , were studied in streptozotocin-diabetic rats . Regulation SEPP1 FOXO1 17986386 1845996 In conclusion , the selenoprotein P promoter is a target of the Akt/FoxO signal transduction cascade and [SeP] expression is *regulated* at the level of transcription by the forkhead box protein in human and rat hepatoma cells . Regulation SERPINA1 TNF 17937578 1825584 However , after Z SDF transfection , M monocytes failed to increase [alpha (1)-AT] secretion in *response* to stimulation . Regulation SERPINA3 IL6R 9461605 484866 Oncostatin M and the interleukin-6 and soluble complex *regulate* [alpha1-antichymotrypsin] expression in human cortical astrocytes . Regulation SERPINA3 TNF 2461199 100133 Human recombinant only slightly *affects* production of [alpha 1-antichymotrypsin] and albumin in a similar manner as leukocyte cytokines . Regulation SERPINA3 TNF 8747137 343524 We have studied the *effects* of IL-1 , IL-6 and on the expression of the acute-phase protein [alpha 1-antichymotrypsin (ACT)] in human astrocytoma cell lines . Regulation SERPINA4 FOXO1 20081110 2212550 Pivotal *role* of JNK dependent activation in downregulation of [kallistatin] expression by oxidative stress . Regulation SERPINA6 IL1B 9360537 462330 The present study investigated the *effects* of interleukin-6 (IL-6) , , and dexamethasone on [CBG] synthesis by a clone of human hepatoblastoma derived ( HepG2 ) cell line . Regulation SERPINB2 IL1B 10743860 680565 Our previous studies had demonstrated that in inflamed gingival tissues , tissue-type plasminogen activator (t-PA) is significantly increased in the extracellular matrix of the connective tissue and that can up *regulate* the level of t-PA and [plasminogen activator inhibitor-2] ( PAI-2 ) synthesis by human gingival fibroblasts . Regulation SERPINB2 PLAT 2494165 108006 [Plasminogen activator inhibitor-2] ( PAI-2 ) can *regulate* the formation of plasmin by inhibiting urokinase and . Regulation SERPINB2 PLAU 11348470 814403 activity is specifically *controlled* by [plasminogen activator inhibitor-1 and -2] . Regulation SERPINB2 TNF 10469140 641014 Here we have examined whether [PAI-2] gene transcription in *response* to may be mediated through a regulatory pathway involving the transcription factor , NF-kappaB . Regulation SERPINB2 TNF 10469140 641015 While no evidence was found for *regulation* of the [PAI-2] gene through either of these two sites , one of the NF-kappaB-like motifs , transcriptional regulatory motif ( TRM ) , present at position -400 was found to be essential for constitutive PAI-2 transcription , as mutation of this motif abolished basal PAI-2 promoter activity in both monocyte-like U937 cells and HT1080 fibrosarcoma cells . Regulation SERPINB2 TNF 2324095 132182 [PAI-2] mRNA accumulation in *response* to was inhibited , but not completely abolished , by cAMP elevating agents , suggesting that cAMP also exerted its inhibitory effect at the translation level . Regulation SERPINB2 TNF 8898893 393157 However , treatment of cells with TNF results in a profound selective reduction in site-B binding activity , suggesting that this site plays a significant role in mediated *regulation* of [PAI-2] gene expression . Regulation SERPINB3 EDN2 1725345 176811 The stimulation of SCC by endothelin was likely to be due to an increase to anion secretion as removal of Cl from the incubation medium markedly reduced the [SCC] *response* to . Regulation SERPINB3 EDN2 2482100 122769 4. The *effect* of on [SCC] was mediated through an increase in prostaglandin synthesis by the tissues and was not blocked by an antagonist of angiotensin II ( Sar1 Ile8 angiotensin II ) or of adrenaline ( propranolol ) . Regulation SERPINB3 IL1B 21912958 2524871 In the present study , we examined the potential *role* and prognostic value of in esophageal [squamous cell carcinoma (SCC)] . Regulation SERPINB3 MMP28 18284387 1885369 The *role* of in RDEB associated [SCC] is not known . Regulation SERPINB3 MMP7 18284387 1885384 The *role* of in RDEB associated [SCC] is not known . Regulation SERPINB3 TNF 12437110 1016147 Next , we studied the *effect* of on [SCCA1] and SCCA2 mRNA expression in HSC cell lines . Regulation SERPINB3 TNF 1925114 168749 We examined the *effect* of human recombinant on the potential difference ( PD ) and [short circuit current (SCC)] of canine tracheal epithelium using an Ussing chamber . Regulation SERPINB3 TNF 8658019 364924 The stimulatory *effect* of ( 1,000 IU/ml ) on the production of [SCC] antigen was also observed in the normal squamous epithelium tissue . Regulation SERPINB4 TNF 12437110 1016148 Next , we studied the *effect* of on SCCA1 and [SCCA2] mRNA expression in HSC cell lines . Regulation SERPINB5 F2R 21147226 2396189 In turn , the , PAR-1 , *regulates* the expression of the gap junction protein Connexin-43 and the tumor suppressor gene [Maspin] . Regulation SERPINE1 ARSA 2371491 138363 We therefore investigated by a double-blind placebo controlled crossover study the *effects* of oral ( 500 mg/day for 3 days ) on platelet PAI-1 release and on plasma [PAI-1] levels of healthy male volunteers . Regulation SERPINE1 EPHB2 14631113 1170494 Based on these results , we suggest that both MEK and are *involved* in the induction of [PAI-1] gene expression during cell adhesion . Regulation SERPINE1 F2R 9579636 503394 The present study demonstrates that the , pertussis toxin-sensitive G protein , genistein-sensitive tyrosine kinase , phospholipase C , and protein kinase C may be *involved* in thrombin induced [PAI-1] production in cultured baboon aortic SMC . Regulation SERPINE1 IL1B 11238529 790736 *regulates* urokinase plasminogen activator (u-PA) , u-PA receptor , soluble u-PA receptor , and [plasminogen activator inhibitor-1] messenger ribonucleic acid expression in cultured human endometrial stromal cells . Regulation SERPINE1 IL1B 12362236 995100 Previous findings suggest that tumor necrosis factor-alpha (TNF-alpha) and are *responsible* for the increase in the level of [PAI-1] . Regulation SERPINE1 IL1B 12362236 995102 These results suggest that [PAI-1] increase might be *independent* of TNF-alpha and . Regulation SERPINE1 IL1B 16427616 1534067 We have studied the *effect* of , one of major cytokines also active in the nervous system , on the angiotensin II-induced expression of [PAI-1] in human astrocytes . Regulation SERPINE1 IL1B 20018936 2210815 and EGR-1 is enriched at the promoters of tissue factor and [plasminogen activator inhibitor 1] in *response* to , and attenuated by PD98059 , Garcinol , and mitogen and stress activated protein kinase 1/2 short interfering RNA . Regulation SERPINE1 IL1B 2257301 146381 The *effect* of on [PAI-1] release by endothelial cells closely resembled that observed for monocytes . Regulation SERPINE1 IL1B 7525383 276915 Our objective was to delineate the mechanisms by which PGE2 and , inflammatory mediators commonly found at sites of inflammation , *regulate* the expression and synthesis of [PAI-1] in human synoviocytes . Regulation SERPINE1 MAP2K6 14631113 1170500 Based on these results , we suggest that both and ERK are *involved* in the induction of [PAI-1] gene expression during cell adhesion . Regulation SERPINE1 MAP2K6 22064653 2540486 Furthermore , [PAI-1] upregulation in shDLC1 cells is pathway *dependent* and is able to promote in vitro angiogenesis . Regulation SERPINE1 MAP2K6 22064653 2540494 Together , our results show that at least the following two new mechanisms are involved in DLC1 mediated normal cell migration : ( i ) DLC1 modulates the expression of [PAI-1] , which is a negative regulator for cell migration , in a GAP domain and *dependent* manner and ( ii ) Independent of PAI-1 , the interaction of DLC1 with tensin members positively regulates cell migration . Regulation SERPINE1 MMP28 21465481 2523678 Under normal physiologic conditions , [PAI-1] *controls* the activities of proteolytic activities and thus maintains the tissue homeostasis . Regulation SERPINE1 MMP7 21465481 2523693 Under normal physiologic conditions , [PAI-1] *controls* the activities of proteolytic activities and thus maintains the tissue homeostasis . Regulation SERPINE1 PLAT 11918547 925613 *Regulation* of [plasminogen activator inhibitor-1] secretion by urokinase and in rat epithelioid-type smooth muscle cells . Regulation SERPINE1 PLAT 1898737 152025 The *effects* of recombinant ( rt-PA ) and of an inactive mutant of rt-PA , obtained by mutagenesis of the active site Ser478 to Ala ( rt-PA-Ala478 ) , on the synthesis and secretion of [plasminogen activator inhibitor-1] ( PAI-1 ) by human umbilical vein endothelial cells ( HUVEC ) in culture were studied . Regulation SERPINE1 PLAT 21465481 2523696 Under normal physiologic conditions , [PAI-1] *controls* the activities of proteolytic activities and thus maintains the tissue homeostasis . Regulation SERPINE1 PLAT 21790972 2579288 The increases in tPA , uPA , [PAI-1] and a2-antiplasmin may counteract each other so that plasmin activity is not significantly altered in AD , but increased may also *affect* synaptic plasticity , excitotoxic neuronal death and apoptosis . Regulation SERPINE1 PLAT 7792744 313461 One subject had clearly higher pre-exercise [PAI] activity and smaller *response* to exercise as compared to other subjects . Regulation SERPINE1 PLAT 9345281 459357 The expression of was much higher in growth promoting than in static culture conditions ( i.e. , cultured at low density and/or on a collagen coated dish ) , and that of [PAI-1] was *regulated* in the opposite direction . Regulation SERPINE1 PLAU 10817507 693724 This indicated that the inhibitory activity of [PAI-1] was required for its anti-apoptotic effect but the receptor was not *involved* . Regulation SERPINE1 PLAU 11348470 814402 activity is specifically *controlled* by [plasminogen activator inhibitor-1] and -2 . Regulation SERPINE1 PLAU 17258797 1783464 activity is *controlled* by its principal inhibitor , the [PA inhibitor type-1 (PAI-1)] , but it can also be inhibited by PAI-3 . Regulation SERPINE1 PLAU 19123477 2037345 Plasmin(ogen) is activated on cell surfaces by , and is *regulated* by uPAR and [plasminogen activator inhibitor-1] ( PAI-1 ) . Regulation SERPINE1 PLAU 21465481 2523697 Under normal physiologic conditions , [PAI-1] *controls* the activities of proteolytic activities and thus maintains the tissue homeostasis . Regulation SERPINE1 TNF 10208482 607040 Furthermore our data support the possibility of a main *role* of endogenous on human adipose tissue [PAI-1] expression . Regulation SERPINE1 TNF 10872824 707139 Secretion of TGFbeta ( transforming growth factor beta ) and ( tumor necrosis factor alpha ) , possible *regulators* of [PAI-1] expression and secretion , were not stimulated by treatment with 1.0 mM homocysteine . Regulation SERPINE1 TNF 11336794 812136 The stimulating *effect* of on [PAI-1] synthesis was attenuated by the pretreatment of HUVEC with daunorubicin . Regulation SERPINE1 TNF 12362236 995098 The endotoxin induced [plasminogen activator inhibitor-1] increase in rabbits is not *dependent* and can occur in the absence of interleukin-1beta . Regulation SERPINE1 TNF 12362236 995099 Previous findings suggest that and interleukin-1beta (IL-1beta) are *responsible* for the increase in the level of [PAI-1] . Regulation SERPINE1 TNF 12362236 995101 These results suggest that [PAI-1] increase might be *independent* of and IL-1beta . Regulation SERPINE1 TNF 12511982 1027608 We observed an inhibition of stimulatory *effect* of on [PAI-1] expression also at the level of the PAI-1 promoter in cells transfected with a PAI-1 promoter fragment ( +71 to -800 ) . Regulation SERPINE1 TNF 12598326 1062059 Divergent *roles* for p55 and p75 receptors in the induction of [plasminogen activator inhibitor-1] . Regulation SERPINE1 TNF 12811828 1102947 This lack of effect was not due to a default of TNFalpha signaling since [PAI-1] synthesis was still stimulated in *response* to exogenous . Regulation SERPINE1 TNF 15677734 1402476 We investigated the regulatory *effects* of and IL-6 on [PAI-1] gene induction in human adipose tissue . Regulation SERPINE1 TNF 15839049 1398015 We also closely examined the *effects* of hypoxia and on [PAI-1] expression in cultured human proximal renal tubular cells ( HRCs ) . Regulation SERPINE1 TNF 16014034 1431795 Synergistic *effect* of hypoxia and on production of [PAI-1] in human proximal renal tubular cells . Regulation SERPINE1 TNF 16014034 1431800 We also closely examined the *effects* of hypoxia and on [PAI-1] expression in cultured human proximal renal tubular cells ( HPTECs ) . Regulation SERPINE1 TNF 17046548 1635757 To address the mechanism underlying the up-regulation of hepatic PAI-1 in obesity , we tested the *effects* of , an important link between obesity and insulin resistance , on [PAI-1] production in the nonmalignant human hepatocyte cell line , THLE-5b . Regulation SERPINE1 TNF 1771617 174886 As with the case of PMA , and IL-6 induced PL-21 cells to macrophage-like cells , but did not *affect* the [PAI] activity . Regulation SERPINE1 TNF 1870266 164138 As with the case of PMA , and IL-6 induced PL-21 cells to macrophage-like cells , but did not *affect* the [PAI] activity . Regulation SERPINE1 TNF 21494547 2418111 Mice exposed to inhaled PM exhibited a *dependent* increase in [PAI-1] and an IL-6 dependent activation of coagulation . Regulation SERPINE1 TNF 22019926 2513629 had no *effect* on [PAI-1] production or fibrin deposition . Regulation SERPINE1 TNF 22658637 2643605 Our findings suggested that simvastatin counteracted the stimulatory *effect* of on secretion and expression of MCP-1 , [PAI-1] and adiponectin , implying a potential anti-atherogenic effect during the inflammatory process ; Regulation SERPINE1 TNF 7949170 277326 A TNF-alpha-mutant ( Trp32Thr86TNF alpha ) that specifically recognizes the 55-kD TNF-receptor , mimicked the *effects* of on both [PAI-1] and u-PA . Regulation SERPINE1 TNF 8088923 271674 We have investigated the *effect* of on the synthesis and/or steady-state mRNA levels of collagen , alkaline phosphatase (ALP) , plasminogen activators (PAs) and their inhibitor [PAI-1] , and collagenases ( MMPs ) and their inhibitor TIMP-1 by human osteoblastic , HOS TE85 , cells in monolayer cultures . Regulation SERPINE1 TNF 8603504 350752 This study examined the *effects* of and plasminogen on collagenase , stromelysin , and [plasminogen activator inhibitor-1] ( PAI-1 ) synthesis of collagenase and stromelysin , which remained predominantly in proenzyme forms , as determined by Western analysis of culture media . Regulation SERPINE1 TNF 8627066 361082 Thus , an increased [PAI-1] *response* to may be associated with fatality , probably because of polymorphism of the PAI-1 gene . Regulation SERPINE1 TNF 9048615 416830 *regulates* [plasminogen activator inhibitor-1] in rat testicular peritubular cells . Regulation SERPINE1 TNF 9048615 416831 We examined the *regulation* by of [plasminogen activator inhibitor-1] ( PAI-1 ) in cultured peritubular cells recovered from 20-day-old rat testes . Regulation SERPINE1 TNF 9048615 416832 *action* on [PAI-1] , like that of TGF alpha demonstrated previously , was masked by a preexposure to phorbol myristate acetate ( a stimulator of protein kinase C ) and strongly reduced by staurosporine ( an inhibitor of the protein kinase C ) . Regulation SERPINE1 TNF 9048615 416834 Together , the present findings suggest that some of the biological *effects* of on [PAI-1] might be secondary to de novo synthesis of EGFR . Regulation SERPINE1 TNF 9048615 416835 Because TNF alpha probably originates from testicular macrophages , such a *regulation* of [PAI-1] by may occur in the context of physiological interactions between the testis and the immune system . Regulation SERPINE1 TNF 9259107 448587 Although a recent study insists that inhibition of tumor necrosis factor alpha (TNF alpha) does not reduce the induction of PAI-1 by endotoxin in rats , we imagine that is *involved* in the induction of [PAI-1] by endotoxin , because endotoxin treatment induces TNF alpha and administration of TNF alpha induces PAI-1 both in vitro and in vivo . Regulation SERPINE1 TNF 9259107 448588 These results suggest that is *responsible* , at least in part , for the induction of [PAI-1] by endotoxin in vivo . Regulation SERPINE2 IL1B 11814314 892832 We have examined expression of the components of the plasminogen activation system in human astrocytoma U373-MG cells and found that , tumour necrosis factor alpha TNF-alpha ) , interferon gamma (INF-gamma) and epidermal growth factor (EGF) specifically *regulate* the expression of tissue-type plasminogen activator (t-PA) , urokinase-type plasminogen activator ( u-PA ) , plasminogen activator inhibitor type 1 ( PAI-1 ) and [protease nexin-1 (PN-1)] . Regulation SERPINE2 TNF 11814314 892829 We have examined expression of the components of the plasminogen activation system in human astrocytoma U373-MG cells and found that interleukin 1beta (IL-1beta) , tumour necrosis factor alpha ) , interferon gamma (INF-gamma) and epidermal growth factor (EGF) specifically *regulate* the expression of tissue-type plasminogen activator (t-PA) , urokinase-type plasminogen activator ( u-PA ) , plasminogen activator inhibitor type 1 ( PAI-1 ) and [protease nexin-1 (PN-1)] . Regulation SERPINF1 TP63 15856012 1432693 Collectively , and p73 may be *involved* in cell fate by inducing [PEDF] expression . Regulation SETBP1 TNF 9826442 550607 We conclude that , not CD154 , *plays* the major role in [SEB-driven] , CD4 ( + ) T cell induced endothelial cell activation in vitro . Regulation SETD2 CTGF 23530034 2777440 Notably , silencing of endogenous CCN2 increased HIF-1a levels and its target gene expression , suggesting a *role* for in controlling basal [HIF-1a] levels . Regulation SETD2 EGLN3 20978507 2344221 *regulates* degradation of [HIF-1a] . Regulation SETD2 EGLN3 22451659 2594893 Expression of prolyl hydroxylases ( PHDs ) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc : distinct *roles* of PHD2 and proteins in controlling [HIF-1a] activity in hypoxia . Regulation SETD2 EPHB2 10683440 669570 In this report , we investigated the activation of in hypoxia and their *involvement* in [HIF-1] activation . Regulation SETD2 EPHB2 12447987 1032130 *Role* of and calcium in the hypoxia induced activation of [HIF-1] . Regulation SETD2 LAMB3 18713836 1955631 In this context , we demonstrate that [HIF1] *controls* the expression of , one of the major epithelial cell adhesion ligands involved in cell migration and invasion . Regulation SETD2 SPHK1 20661259 2388858 The *involvement* of in LPS induced Toll-like receptor 4-mediated accumulation of [HIF-1a] protein , activation of ASK1 and production of the pro-inflammatory cytokine IL-6 . Regulation SETD2 SPHK1 21392092 2453289 Consistently , siRNA-SPHK1 and sphingosine kinase inhibitor (SKI) effectively blocked the expression of HIF-1a , phospho-AKT and vascular endothelial growth factor ( VEGF ) production in PC-3 cells under hypoxia , suggesting the *role* of in melatonin inhibited [HIF-1a] accumulation . Regulation SETD2 TCN1 18639543 1954647 We here demonstrated the *effect* of on [HIF-1] activation induced by hypoxia or CoCl2 . Regulation SETD2 TNF 24213609 2897245 Both hypoxia and inflammatory factor TNF-a regulate gene expression of [HIF-1a] , but how RTEF-1 and coordinately *regulate* HIF-1a gene transcription is unclear . Regulation SETD7 TNF 19262565 2062986 Lysine methyltransferase [Set9] physically associates with RelA in vitro and in vivo in *response* to stimulation . Regulation SFTPA1 AGR2 15175287 1254883 Our results identified upstream promoter sequences necessary for system *regulation* of [spa] expression . Regulation SFTPA2 TNF 11454638 837702 These data confirm the *effect* of on the immune changes in [SpA] , and provide insights into the mechanisms involved in TNFalpha blockade . Regulation SFTPB FOXA1 7958446 278169 Our results suggest that [SPB] promoter activity is *regulated* by and HFH-8 proteins in a cell type-specific manner . Regulation SFTPB TUB 9130700 426919 Previously , we have shown that the gamma-tubulin and the spindle pole body component Spc98p are *involved* in microtubule organization by the yeast microtubule organizing centre , the [spindle pole body (SPB)] . Regulation SFTPC EPHB2 17481939 1750529 Pretreatment of the cells with U0126 , an MEK inhibitor , markedly attenuated the SPC induced expression of FN and delayed phosphorylation of Smad2 , suggesting that is *involved* in the [SPC] induction of FN expression through activation of Smad2 . Regulation SGOL1 STK39 18083840 1837677 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation SGOL2 STK39 18083840 1837812 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation SH2D1A FAS 21109225 2355399 Germline mutations in FASL and FAS impair *dependent* apoptosis and cause recessively or dominantly inherited autoimmune [lymphoproliferative syndrome] ( ALPS ) . Regulation SH3D19 IL1B 18438857 1915467 Binding of [c/EBP] to this site was *regulated* by TNFalpha but not , resulting in down-regulation of cd-rap expression . Regulation SH3D19 TNF 18438857 1915466 Binding of [c/EBP] to this site was *regulated* by but not IL-1beta , resulting in down-regulation of cd-rap expression . Regulation SHB ARSA 7203279 13281 However , at higher dose levels , MB masked the preventive *effect* of on [SHb-emia] . Regulation SHBG HBEGF 16449863 1521972 Important modern prognostic markers such as heart rate recovery ( HRR ) , chronotropic index , delayed [systolic blood pressure (SBP)] *response* and have been evaluated by treadmill exercise testing . Regulation SHBG TNF 8487647 219174 [SHBG] levels were not *affected* by . Regulation SHC1 EPHB2 11228049 763994 PD98059 inhibited activation of and LY294002 repressed activation of Akt in response to IGF-I , but did not *affect* tyrosine phosphorylation of the IGF-IR , IRS-1 , IRS-2 , or [Shc] . Regulation SHC1 MMP28 16336626 1503788 In contrast , phosphorylation of the EGF-R , [Shc] and ERK1/2 by EGF and HB-EGF was *independent* of PKC and activity . Regulation SHC1 MMP7 16336626 1503803 In contrast , phosphorylation of the EGF-R , [Shc] and ERK1/2 by EGF and HB-EGF was *independent* of PKC and activity . Regulation SHH ANGPT1 23894369 2821831 Recombinant human [sonic hedgehog protein] *regulates* the expression of ZO-1 and occludin by activating in stroke damage . Regulation SHH FOXA1 15668254 1388279 and Foxa2 *regulated* [Shh] ( sonic hedgehog ) and Shh dependent genes in the respiratory epithelial cells that influenced the expression of genes in the pulmonary mesenchyme that are required for branching morphogenesis . Regulation SHH FOXA1 21093585 2383164 and Foxa2 positively and negatively *regulate* [Shh] signalling to specify ventral midbrain progenitor identity . Regulation SHH TMEM100 10475061 642594 [Sonic Hedgehog/Patched] signaling *involves* another , Smoothened , and its intracellular effectors , including the proto-oncogene GLI1 . Regulation SHH TMEM156 10475061 642612 [Sonic Hedgehog/Patched] signaling *involves* another , Smoothened , and its intracellular effectors , including the proto-oncogene GLI1 . Regulation SHH TMEM211 10475061 642692 [Sonic Hedgehog/Patched] signaling *involves* another , Smoothened , and its intracellular effectors , including the proto-oncogene GLI1 . Regulation SHH TMEM213 10475061 642629 [Sonic Hedgehog/Patched] signaling *involves* another , Smoothened , and its intracellular effectors , including the proto-oncogene GLI1 . Regulation SHH ZIC2 23678105 2785442 Analyses of the molecular and cellular consequences of introducing Shh into the developing VTC and Zic2 and Boc into the central retina indicate that Boc expression alone is insufficient to fully activate the ipsilateral program and that *regulates* [Shh] expression . Regulation SIGLEC7 NGFR 15955426 1422033 TrkA *plays* a role in the modulation of [p75NTR] expression . Regulation SIRT1 FOXO1 21743036 2466779 Mechanistically , [SIRT1] *controls* acetylation status and functional activity of that directly binds to the ATGL promoter and regulates ATGL gene transcription . Regulation SIRT1 PGC 24297698 2916763 Using cell lines differentially expressing FXRa in overexpression and silencing experiments , we demonstrated that [SIRT1] activated the core promoter in an FXRa- and *dependent* manner . Regulation SIRT3 PGC 21454513 2422183 Erra knockdown assays indicated that Erra is required for full induction of [Sirt3] gene expression in *response* to . Regulation SIRT5 PGC 24687991 2949255 Moreover , [SIRT5] levels are *regulated* by and AMPK , which have opposite effects on its expression.-Buler , M. , Aatsinki , S.-M. , Izzi , V. , Uusimaa , J. , Hakkola , J . SIRT5 is under the control of PGC-1a and AMPK and is involved in regulation of mitochondrial energy metabolism . Regulation SKA1 CLU 19805566 2187024 We aimed to evaluate the *effect* of on the in vitro production of three major virulent exoproteins , namely , streptolysin O (Slo) , NAD glycohydrolase ( Nga ) , and [streptokinase (Ska)] , by CLI-resistant S. pyogenes strains . Regulation SKA1 STK39 18083840 1837707 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation SKA2 CLU 19805566 2187023 We aimed to evaluate the *effect* of on the in vitro production of three major virulent exoproteins , namely , streptolysin O (Slo) , NAD glycohydrolase ( Nga ) , and [streptokinase (Ska)] , by CLI-resistant S. pyogenes strains . Regulation SKA2 STK39 18083840 1837692 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation SKA3 CLU 19805566 2187022 We aimed to evaluate the *effect* of on the in vitro production of three major virulent exoproteins , namely , streptolysin O (Slo) , NAD glycohydrolase ( Nga ) , and [streptokinase (Ska)] , by CLI-resistant S. pyogenes strains . Regulation SKP1 IL1B 16407046 1513304 We investigated whether HDSMCs are capable of expressing and releasing MCP-1 , IL-6 and [SCF] in *response* to IL-4 , IL-13 , and tumor necrosis factor-alpha . Regulation SKP1 IL1B 16584593 1544092 there were not *effects* of expression on expressions of IL-6 and [SCF] . Regulation SKP1 TNF 10067879 594038 Activin , TGF beta , TGF alpha , and had no *effect* on [SCF] gene expression in vitro . Regulation SKP1 TNF 16407046 1513303 We investigated whether HDSMCs are capable of expressing and releasing MCP-1 , IL-6 and [SCF] in *response* to IL-4 , IL-13 , IL-1beta and . Regulation SKP1 TNF 23662587 2805503 Comparison of the stimulatory *effects* of interleukin (IL)-1a or on [SCF] production between SK cells and NHK demonstrated that SK cells do not respond to IL-1a or TNF-a to stimulate production of SCF , whereas a significant stimulation of SCF is elicited by those same cytokines in NHK . Regulation SKP2 CCND1 16924241 1692239 Mutant B-RAF signaling and *regulate* [Cks1/S-phase kinase associated protein 2-mediated] degradation of p27Kip1 in human melanoma cells . Regulation SKP2 CCND1 16924241 1692248 Additionally , B-RAF and *control* the levels of [S-phase kinase associated protein 2] ( Skp2 ) that directs ubiquitin mediated proteolysis of p27 ( Kip1 ) . Regulation SKP2 EPHB2 24177224 2868306 *dependent* downregulation of [Skp2] reduces Myc activity with HGF , leading to inhibition of cell proliferation through a decrease in Id1 expression . Regulation SKP2 EPHB2 24177224 2868318 Overall , these mechanistic findings provide the first evidence that *dependent* downregulation of [Skp2] reduced Myc activity , leading to HGF induced inhibition of cell proliferation through decreased Id1 expression . Regulation SKP2 ID1 24177224 2868314 Furthermore , Skp2 regulated expression by regulating Myc activity , and the regulation of [Skp2] is *involved* in the activity of p16 promoter through regulation of Id1 expression . Regulation SKP2 IFI27 11226270 788070 The [F-box protein Skp2] ( S-phase kinase associated protein 2 ) positively *regulates* the G ( 1 ) -S transition by controlling the stability of several G ( 1 ) regulators , such as the cell cycle inhibitor . Regulation SKP2 IFI27 12107105 963017 [SKP2] positively *regulates* progression of cell cycle by targeting several regulators , such as the cell-cycle inhibitor ( KIP1 ) , for ubiquitin mediated degradation . Regulation SKP2 IFI27 12133571 966962 The [F-box protein Skp2] *regulates* G1-S transition by controlling . Regulation SKP2 WIF1 19174556 2032536 , a Wnt pathway inhibitor , *regulates* [SKP2] and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells . Regulation SLAMF1 TNF 15123745 1242410 Although [SLAM] *controls* production of IL-12 , , and nitric oxide in response to lipopolysaccharide (LPS) by macrophages , SLAM does not regulate phagocytosis and responses to peptidoglycan or CpG . Regulation SLC11A1 TNF 22508410 2589528 The *effect* of or interleukin-6 (IL-6) on [Nramp1] expression in PMNLs from controls was also examined . Regulation SLC11A2 TNF 16221503 1517858 *regulates* the mRNA levels of HAMP , IREG1 , [DMT1] and TfR2 in cultured hepatocytes from both iron loaded and control animals . Regulation SLC12A2 EPHB2 11909643 923745 Activation of [NKCC1] by hyperosmotic stress in human tracheal epithelial cells *involves* PKC-delta and . Regulation SLC12A2 EPHB2 11909643 923747 The results indicate that hyperosmotic stress activates [NKCC1] and this activation is *regulated* by PKC-delta and . Regulation SLC12A9 EPHB2 17941827 1849416 Heregulin beta1 promotes breast cancer cell proliferation through *dependent* induction of cyclin D1 and [p21Cip1] . Regulation SLC12A9 EPHB2 19492998 2091376 The NFkB dependent drop in cyclin D1 , along with the *dependent* induction of p21 [Cip1/Kip1] , is responsible for growth arrest . Regulation SLC15A2 EGF 14559717 1186093 These findings demonstrate for the first time mediated *regulation* of [PEPT2] expression in a kidney cell line . Regulation SLC15A2 JAK3 23934551 2861742 *Effect* of on the peptide transporters PEPT1 and [PEPT2] . Regulation SLC16A1 TNF 18054563 1833350 IFN-gamma and did not *affect* [MCT1] mRNA stability but rather down-regulated gene transcription . Regulation SLC16A3 PRKAA1 17909267 1803629 As for the *role* of in the regulation of the monocarboxylate transporters 1 and 4 ( MCT1 and [MCT4] ) , it has been observed that AICAR treatment decreased MCT1 and increased MCT4 mRNA levels . Regulation SLC16A3 PRKAA1 24081524 2888562 *Effect* of activation on monocarboxylate transporter (MCT)1 and [MCT4] in denervated muscle . Regulation SLC16A3 PRKAA2 17909267 1803630 As for the *role* of in the regulation of the monocarboxylate transporters 1 and 4 ( MCT1 and [MCT4] ) , it has been observed that AICAR treatment decreased MCT1 and increased MCT4 mRNA levels . Regulation SLC16A3 PRKAA2 24081524 2888563 *Effect* of activation on monocarboxylate transporter (MCT)1 and [MCT4] in denervated muscle . Regulation SLC16A3 PRKAB1 17909267 1803631 As for the *role* of in the regulation of the monocarboxylate transporters 1 and 4 ( MCT1 and [MCT4] ) , it has been observed that AICAR treatment decreased MCT1 and increased MCT4 mRNA levels . Regulation SLC16A3 PRKAB1 24081524 2888564 *Effect* of activation on monocarboxylate transporter (MCT)1 and [MCT4] in denervated muscle . Regulation SLC16A3 PRKAB2 17909267 1803632 As for the *role* of in the regulation of the monocarboxylate transporters 1 and 4 ( MCT1 and [MCT4] ) , it has been observed that AICAR treatment decreased MCT1 and increased MCT4 mRNA levels . Regulation SLC16A3 PRKAB2 24081524 2888565 *Effect* of activation on monocarboxylate transporter (MCT)1 and [MCT4] in denervated muscle . Regulation SLC16A3 PRKAG1 17909267 1803633 As for the *role* of in the regulation of the monocarboxylate transporters 1 and 4 ( MCT1 and [MCT4] ) , it has been observed that AICAR treatment decreased MCT1 and increased MCT4 mRNA levels . Regulation SLC16A3 PRKAG1 24081524 2888566 *Effect* of activation on monocarboxylate transporter (MCT)1 and [MCT4] in denervated muscle . Regulation SLC16A3 PRKAG2 17909267 1803634 As for the *role* of in the regulation of the monocarboxylate transporters 1 and 4 ( MCT1 and [MCT4] ) , it has been observed that AICAR treatment decreased MCT1 and increased MCT4 mRNA levels . Regulation SLC16A3 PRKAG2 24081524 2888567 *Effect* of activation on monocarboxylate transporter (MCT)1 and [MCT4] in denervated muscle . Regulation SLC1A6 PIK3CA 18540911 1934665 The results of this study suggest that chronic ethanol exposure decreases [EAAT4] activity and that PKC and may be *involved* in these effects . Regulation SLC1A6 PIK3R1 18540911 1934666 The results of this study suggest that chronic ethanol exposure decreases [EAAT4] activity and that PKC and may be *involved* in these effects . Regulation SLC22A12 PDZK1 15304510 1322347 The multivalent PDZ domain containing protein *regulates* transport activity of renal urate-anion exchanger [URAT1] via its C terminus . Regulation SLC22A3 AXIN2 17072303 1649868 *regulates* [EMT] by acting as a nucleocytoplasmic chaperone for GSK3beta , the dominant kinase responsible for controlling Snail1 protein turnover and activity . Regulation SLC22A3 CTGF 16867255 1592899 Our data provides further evidence that might be *involved* in Ang II-induced [EMT] in PTC . Regulation SLC22A3 CTGF 17161611 1663711 The cytokine ( CTGF or CCN2 ) *plays* an important role in [epithelial-mesenchymal transition (EMT)] of tubular epithelial cells ( TECs ) . Regulation SLC22A3 CTGF 17161611 1663715 All data showed that P2 bound preferably on the surface of NRK-52E cells and inhibited the *effect* of on [EMT] induction and cell fibrogenesis , probably by occupying the binding sites of CTGF within its potential receptors . Regulation SLC22A3 EPHB2 15548370 1338397 However , the *role* of in the induction of TGF-beta1 mediated [EMT] remains unclear . Regulation SLC22A3 EPHB2 17881458 1818602 Oncostatin M-induced effects on [EMT] in human proximal tubular cells : differential *role* of signaling . Regulation SLC22A3 EPHB2 21093414 2371832 In conclusion , this study shows for the first time that Snail transcription factor can regulate oxidative stress enzymes and increase ROS mediated [EMT] *regulated* in part by activation . Regulation SLC22A3 EPHB2 21792635 2584893 Inhibiting p38 and signalling had no *effect* on [EMT] . Regulation SLC22A3 EPHB2 24569586 2924734 We measured the *involvement* of Syk , Src , PI3K/Akt , and signaling , but not Smad , in [EMT] by EBV induced TGF-ß1 . Regulation SLC22A3 FOXQ1 21346143 2415469 In this study , we defined a critical functional *role* for the Forkhead transcription factor in regulating [EMT] in breast cancer cells . Regulation SLC22A3 FOXQ1 21346143 2415472 Our findings define a key *role* for in regulating [EMT] and aggressiveness in human cancer . Regulation SLC22A3 FOXQ1 23403865 2748689 In this study , we defined a pivotal functional *role* for the Forkhead transcription factor in regulating [EMT] in bladder cancer . Regulation SLC22A3 FUT4 23887626 2821547 This study explores the molecular mechanisms of the *involvement* of in [EMT] in breast cancer cells . Regulation SLC22A3 ID1 22226665 2843146 Our results suggest that may *play* roles in tumor progression and [EMT] activation in bladder cancer . Regulation SLC22A3 JAG1 14976548 1213156 Our findings identify a new mechanism for functional integration of Jagged1/Notch signalling and coordinated activation of the Hey1 transcriptional repressor controlled by TGF-beta/Smad3 , and demonstrate functional *roles* for Smad3 , Hey1 , and in mediating TGF-beta induced [EMT] . Regulation SLC22A3 KRT38 23536778 2762695 These mice were crossed into a newly generated Cre-recombinase inducible KRAS-driven murine lung cancer model to examine the *effect* of loss on morphology , invasion and metastasis as well as expression of [EMT] related genes in the resulting tumors . Regulation SLC22A3 MUC16 21326240 2403908 The *role* of in [EMT] was investigated using single-chain antibody mediated knockdown of cell surface CA125/MUC16 in overexpressing EOC NIH : OVCAR3 cells . Regulation SLC22A3 NEDD9 21829474 2468029 In this study , we wished to discern the role of NEDD9 in breast cancer progression and to investigate the molecular mechanism by which *regulates* [EMT] and promotes invasion in triple negative breast cancer . Regulation SLC22A3 NEDD9 24728978 2935861 While *plays* a crucial role in [epithelial-mesenchymal transition (EMT)] , the functional mechanism underlying NEDD9 mediated EMT in prostate cancer ( PCa ) remains uncertain . Regulation SLC22A3 PIGR 22025622 2508055 *plays* a role in the induction of [EMT] . Regulation SLC22A3 PLAU 24195704 2883018 In a recent study published in Respiratory Research , Qin Wang and colleagues investigated the *role* of receptor ( uPAR ) in [EMT] in small airway epithelium of COPD patients . Regulation SLC22A3 TNF 20128678 2207564 Therefore , the authors investigated whether *affected* TGF-beta1 induced [EMT] . Regulation SLC22A3 TNF 22161143 2542931 These findings provide direct evidence of the *effects* of RAW 264.7 derived on TGF-ß induced [EMT] in A549 cells , which is transduced in part by NF?B signalling . Regulation SLC22A3 TNF 22791341 2676548 Ectopic expression of VDR counteracted the synergistic *effect* of and TGF-ß1 on [EMT] . Regulation SLC22A3 TNF 22791341 2676549 Furthermore , knockdown of VDR using a small interfering RNA strategy mimicked the *effect* of on facilitating [EMT] . Regulation SLC22A3 TNF 22903530 2701536 The *effect* of on [EMT] activation in CCA cells was also demonstrated . Regulation SLC22A3 TP63 23658742 2784762 We therefore investigated the *role* of in [EMT] . Regulation SLC22A3 VSNL1 22479362 2578862 These findings indicate that is *involved* in [EMT] of SCC by regulating the transcription factor Snail1 in a cAMP dependent manner . Regulation SLC22A5 PDZK1 15523054 1367269 Biotinylation study of surface proteins revealed minimal *effect* of on cell-surface expression of [OCTN2] . Regulation SLC25A20 PGC 22713466 2626878 *regulates* mouse [carnitine-acylcarnitine translocase] through estrogen related receptor a . Regulation SLC26A3 CTGF 17052405 1636209 This study investigated the *role* of in hyperoxia induced [CLD] . Regulation SLC26A3 PDZK1 19447883 2101471 DRA also possesses a PDZ binding motif , but the *roles* of interactions with E3KARP or and Ca ( 2+ ) ( i ) in [DRA] regulation are unknown . Regulation SLC26A6 PDZK1 17120766 1652190 Finally , we demonstrated an essential *role* for the scaffolding protein in apical membrane expression of [SLC26A6] . Regulation SLC28A1 HNF4A 19228884 2050431 In cotransfection experiments , the transcriptional coactivator peroxisome proliferator activated receptor-gamma coactivator-1alpha further increased , whereas the bile acid-inducible corepressor small heterodimer partner reduced , *dependent* [CNT1] promoter activity . Regulation SLC28A1 INS 17537394 1778407 Rapamycin abolished the *effect* on the [CNT1] mRNA level , but not on the CNT2 mRNA . Regulation SLC28A1 INS 17537394 1778410 Overall , our results demonstrate that the expression level of ENT2 , [CNT1] , and CNT2 transporters in CFs is differentially *regulated* by . Regulation SLC28A2 SLC28A1 17187757 1679996 HNF4alpha is a major determinant of expression , whereas C/EBPalpha and HNF3gamma *modulate* [SLC28A2] gene expression . Regulation SLC2A1 ADRB2 24504055 2918688 dependent *regulation* of [GLUT-1] and HK-2 was determined by in vitro pharmacologic intervention . Regulation SLC2A1 HBEGF 12661915 1074278 In conclusion , PKC mediated transactivation followed by ERK activation *plays* a predominant role in the induction of [GLUT1] expression by Ang II . Regulation SLC2A1 IL1B 12915684 1130011 In vitro , [GLUT1] and GLUT3 were not directly *regulated* by 17beta-estradiol , progesterone , or , IL-6 , and leukemia inhibitory factor , but GLUT1 mRNA increased progressively in stromal cells , decidualized in vitro . Regulation SLC2A1 MAP2K6 15307820 1333321 In the present study , we show that PMA treatment increases glucose uptake in 3T3-L1 adipocytes by two mechanisms : a *dependent* increase in [GLUT1] ( glucose transporter 1 ) expression levels and a PKClambda dependent translocation of GLUT1 towards the plasma membrane . Regulation SLC2A1 PPBP 1527075 197538 The increased levels of [GLUT-1] protein in *response* to and rCTAP-III-Leu-21 ( des-1-15 ) /NAP-2 were accompanied by an increase in levels of GLUT-1 mRNA of a magnitude sufficient to account for observed increased levels of GLUT-1 . Regulation SLC2A2 IL1B 9989930 597173 When the *effects* of and TNF-alpha on the gene expression of pancreatic [GLUT2] and glucokinase were examined , the level of GLUT2 and glucokinase mRNA in pancreatic islets was significantly decreased . Regulation SLC2A2 TNF 9989930 597172 When the *effects* of IL-1beta and on the gene expression of pancreatic [GLUT2] and glucokinase were examined , the level of GLUT2 and glucokinase mRNA in pancreatic islets was significantly decreased . Regulation SLC2A3 IL1B 11739520 886551 [GLUT3] and GLUT8 mRNA are constitutively expressed in chondrocytes and are not *regulated* by . Regulation SLC2A3 IL1B 12915684 1130014 In vitro , GLUT1 and [GLUT3] were not directly *regulated* by 17beta-estradiol , progesterone , or , IL-6 , and leukemia inhibitory factor , but GLUT1 mRNA increased progressively in stromal cells , decidualized in vitro . Regulation SLC2A4 FOXO1 12414908 1011217 Therefore , we evaluated the *role* of in the regulation of [GLUT4] gene expression in muscle tumorigenesis . Regulation SLC2A4 FOXO1 20406953 2274259 The negative *effect* of over PPARG transcription disappears when FOXO1 is phosphorylated ( p-FOXO1 ) and excluded from the nucleus , whereas PPARG can suppress gene expression of [SLC2A4] . Regulation SLC2A4 PGC 11274399 797719 These data indicate that is a coactivator of MEF2C and can *control* the level of endogenous [GLUT4] gene expression in muscle . Regulation SLC2A4 RAB31 12637568 1079968 Insulin stimulated phosphorylation of a GTPase activating protein *regulates* [GLUT4] translocation . Regulation SLC2A4 TNF 18162526 1883099 The stimulatory *effects* of on cell surface [GLUT4] and glucose uptake were blocked by nuclear factor-kappaB and p38MAPK pathway specific inhibitors ( Bay 11-7082 and SB220025 ) , and these two pathways were stimulated by TNFalpha . Regulation SLC2A4 TNF 18162526 1883102 Furthermore , although TNFalpha increased IL-6 mRNA and protein expression , IL-6 did not mediate the *effects* of on cell surface [GLUT4] levels , which also did not require de novo protein synthesis . Regulation SLC2A4 TNF 8870666 389439 These observations are interesting in light of our previous data demonstrating that *affects* both [GLUT4] transcription and mRNA stability in the 3T3-L1 adipocytes . Regulation SLC2A4RG CCND1 15652748 1364327 Mechanistically , the effects of Vav1 require its [GEF] activity and the activation of Rac1 , PAK1 , and NF-kappaB and *involve* upregulation . Regulation SLC2A4RG GPR115 10882715 730325 Ras-GRF1 is a brain-specific [guanine nucleotide exchange factor (GEF)] for Ras , whose activity is regulated in *response* to Ca ( 2+ ) influx and signals . Regulation SLC2A4RG GPR132 10882715 730314 Ras-GRF1 is a brain-specific [guanine nucleotide exchange factor (GEF)] for Ras , whose activity is regulated in *response* to Ca ( 2+ ) influx and signals . Regulation SLC2A4RG GPR87 10882715 730394 Ras-GRF1 is a brain-specific [guanine nucleotide exchange factor (GEF)] for Ras , whose activity is regulated in *response* to Ca ( 2+ ) influx and signals . Regulation SLC33A1 ANGPT1 14737832 1202860 When [AT1] receptor is blocked and unbound Ang II may act on AT2 receptor and and Ang IV via AT4 receptor might be *involved* in the effects of ARB . Regulation SLC33A1 ANGPT1 18084722 1882977 Role of ACE/AT2R complex in the control of mesenteric resistance artery contraction induced by [ACE/AT1R] complex activation in *response* to . Regulation SLC33A1 HBEGF 11139469 770079 In an in vivo corneal assay , [AT(1)] induced angiogenesis in an *dependent* manner and enhanced the angiogenic activity of VEGF . Regulation SLC33A1 TNF 18852381 1988772 The purpose of this study was to determine the *role* of placental ischemia and in stimulating the [AT1-AA] and the importance of AT1 receptor activation in mediating hypertension during reductions in uterine perfusion pressure ( RUPP ) and chronic TNF-alpha excess in pregnant rats . Regulation SLC33A1 TNF 9231818 445004 We therefore examined the *effects* of interleukin-1 alpha ( 220 U/mL [ 10 ng/mL ] ) , ( 280 U/mL [ 100 ng/mL ] ) , and interferon gamma ( 100 U/mL ) on [Ang II type 1 (AT1)] receptors expressed in rat vascular smooth muscle cells . Regulation SLC38A3 MAPK1 15331357 1287908 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Regulation SLC38A3 MAPK10 15331357 1287909 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Regulation SLC38A3 MAPK11 15331357 1287910 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Regulation SLC38A3 MAPK12 15331357 1287911 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Regulation SLC38A3 MAPK13 15331357 1287912 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Regulation SLC38A3 MAPK14 15331357 1287913 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Regulation SLC38A3 MAPK15 15331357 1287907 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Regulation SLC38A3 MAPK3 15331357 1287914 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Regulation SLC38A3 MAPK4 15331357 1287915 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Regulation SLC38A3 MAPK6 15331357 1287916 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Regulation SLC38A3 MAPK7 15331357 1287917 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Regulation SLC38A3 MAPK8 15331357 1287918 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Regulation SLC38A3 MAPK9 15331357 1287919 We previously reported that whereas *regulates* [G17-stimulation] of AR4-2J cell proliferation , Akt mediates the antiapoptotic action of G17 . Regulation SLC38A3 NEDD4L 12788082 1097136 It is concluded that [SN1] is a *target* for the ubiquitin ligase , which is inactivated by the serum and glucocorticoid inducible kinase SGK1 , its isoform SGK3 , and protein kinase B . Regulation SLC38A3 RHOA 9950815 595758 Because activation of the SRE involves the small GTP binding protein Rho A , we examined the *role* of in [G17] induction of c-fos transcription . Regulation SLC39A14 GPR115 21445361 2412318 The zinc transporter [SLC39A14/ZIP14] *controls* mediated signaling required for systemic growth . Regulation SLC39A14 GPR132 21445361 2412307 The zinc transporter [SLC39A14/ZIP14] *controls* mediated signaling required for systemic growth . Regulation SLC39A14 GPR87 21445361 2412387 The zinc transporter [SLC39A14/ZIP14] *controls* mediated signaling required for systemic growth . Regulation SLC3A2 ITGAL 11165259 782755 We show that [CD98] cross linking persistently activates Rap1 GTPase in a *dependent* manner and induces LFA-1/ICAM-1 mediated cell adhesion in lymphocytes . Regulation SLC4A1 CA12 15764372 1352593 We examined the *effect* of 16 different inhibitors on [AE1] transport activity . Regulation SLC6A2 CALM3 17032905 1674475 Amphetamine induces a *dependent* protein kinase II-dependent reduction in [norepinephrine transporter] surface expression linked to changes in syntaxin 1A/transporter complexes . Regulation SLC6A2 CEBPA 21883217 2491514 Dexamethasone induced up-regulation of the human [norepinephrine transporter] *involves* the glucocorticoid receptor and increased binding of to the proximal promoter of norepinephrine transporter . Regulation SLC6A2 EDN1 18682267 1984588 *Regulation* of the neuronal [norepinephrine transporter] by and -3 in the rat anterior and posterior hypothalamus . Regulation SLC6A2 EDN3 18682267 1984589 *Regulation* of the neuronal [norepinephrine transporter] by in the rat anterior and posterior hypothalamus . Regulation SLC6A2 NR3C1 21883217 2491515 Dexamethasone induced up-regulation of the human [norepinephrine transporter] *involves* the and increased binding of C/EBP-ß to the proximal promoter of norepinephrine transporter . Regulation SLC6A2 PAK1 15684429 1382341 These data provide a novel mechanism for the control of RhoA activity by Rac1 through the *dependent* phosphorylation of [NET1] to reduce its activity as a guanine nucleotide exchange factor . Regulation SLC6A2 PAK2 15684429 1382342 These data provide a novel mechanism for the control of RhoA activity by Rac1 through the *dependent* phosphorylation of [NET1] to reduce its activity as a guanine nucleotide exchange factor . Regulation SLC6A2 PAK3 15684429 1382343 These data provide a novel mechanism for the control of RhoA activity by Rac1 through the *dependent* phosphorylation of [NET1] to reduce its activity as a guanine nucleotide exchange factor . Regulation SLC6A2 PAK4 15684429 1382339 These data provide a novel mechanism for the control of RhoA activity by Rac1 through the *dependent* phosphorylation of [NET1] to reduce its activity as a guanine nucleotide exchange factor . Regulation SLC6A2 PAK6 15684429 1382340 These data provide a novel mechanism for the control of RhoA activity by Rac1 through the *dependent* phosphorylation of [NET1] to reduce its activity as a guanine nucleotide exchange factor . Regulation SLC6A2 PAK7 15684429 1382338 These data provide a novel mechanism for the control of RhoA activity by Rac1 through the *dependent* phosphorylation of [NET1] to reduce its activity as a guanine nucleotide exchange factor . Regulation SLC6A2 PHOX2A 19573018 2129078 In the present study , we examined the possible *effect* of on the in vitro expression of the [norepinephrine transporter (NET)] and dopamine beta-hydroxylase (DBH) , two important markers of the noradrenergic system . Regulation SLC6A2 PKN1 15684429 1382331 negatively *regulates* the activity of the Rho exchange factor [NET1] . Regulation SLC6A2 RAC1 23184663 2723832 *controls* the subcellular localization of the Rho guanine nucleotide exchange factor [Net1A] to regulate focal adhesion formation and cell spreading . Regulation SLC6A2 SMAD1 21986943 2605117 signaling and the MAPK/ERK kinase (MEK)/extracellular signal regulated kinase ( ERK ) pathway were *involved* in [Net1A] upregulation by TGF-ß . Regulation SLC6A2 SMAD2 21986943 2605118 signaling and the MAPK/ERK kinase (MEK)/extracellular signal regulated kinase ( ERK ) pathway were *involved* in [Net1A] upregulation by TGF-ß . Regulation SLC6A2 SMAD3 21986943 2605119 signaling and the MAPK/ERK kinase (MEK)/extracellular signal regulated kinase ( ERK ) pathway were *involved* in [Net1A] upregulation by TGF-ß . Regulation SLC6A2 SMAD4 21986943 2605120 signaling and the MAPK/ERK kinase (MEK)/extracellular signal regulated kinase ( ERK ) pathway were *involved* in [Net1A] upregulation by TGF-ß . Regulation SLC6A2 SMAD5 21986943 2605121 signaling and the MAPK/ERK kinase (MEK)/extracellular signal regulated kinase ( ERK ) pathway were *involved* in [Net1A] upregulation by TGF-ß . Regulation SLC6A2 SMAD6 21986943 2605122 signaling and the MAPK/ERK kinase (MEK)/extracellular signal regulated kinase ( ERK ) pathway were *involved* in [Net1A] upregulation by TGF-ß . Regulation SLC6A2 SMAD7 21986943 2605123 signaling and the MAPK/ERK kinase (MEK)/extracellular signal regulated kinase ( ERK ) pathway were *involved* in [Net1A] upregulation by TGF-ß . Regulation SLC6A2 SMAD9 21986943 2605124 signaling and the MAPK/ERK kinase (MEK)/extracellular signal regulated kinase ( ERK ) pathway were *involved* in [Net1A] upregulation by TGF-ß . Regulation SLC6A2 SYN1 17714497 1794748 We demonstrate that *regulates* the activity and surface expression of the [norepinephrine transporter (NET)] , depending on its expression levels . Regulation SLC6A2 SYN2 17714497 1794749 We demonstrate that *regulates* the activity and surface expression of the [norepinephrine transporter (NET)] , depending on its expression levels . Regulation SLC6A2 SYN3 17714497 1794750 We demonstrate that *regulates* the activity and surface expression of the [norepinephrine transporter (NET)] , depending on its expression levels . Regulation SLC8A1 EPHB2 12502566 1026783 Together , this data indicates that ( 1 ) JNK mediates basal cardiac expression of the NCX1 gene , ( 2 ) and p38 *play* a role in alpha-adrenergic stimulated [NCX1] upregulation , and ( 3 ) p38 activation alone is sufficient for NCX1 upregulation . Regulation SLC9A1 EPHB2 15494214 1354858 The data indicate that ERK activation is essential for phenylephrine stimulation of NHE1 , and that and RhoA are *involved* in LPA stimulation of [NHE1] by more than one mechanism . Regulation SLC9A1 EPHB2 15494214 1354871 These studies indicate a direct involvement of ERK in the alpha ( 1 ) -adrenergic activation of [NHE1] and a significant *role* for both and RhoA in LPA stimulation of NHE1 in CCL39 fibroblasts . Regulation SLC9A1 EPHB2 19542484 2109870 The same amino acids were critical to phenylephrine mediated , *dependent* activation of [NHE1] activity and increased the phosphorylation in intact rat cardiomyocytes . Regulation SLC9A1 SLC9A2 10684820 669722 These results , when interpreted along with those of previous functional studies , may suggest that the apical is *involved* in Na ( + ) reabsorption and the basolateral [NHE1] in HCO ( 3 ) ( - ) secretion in the rat epididymis . Regulation SLC9A1 SLC9A2 11447025 835464 We conclude that in rabbit gastric epithelium , [NHE1] and NHE4 regulate cell volume and NHE1 and *regulate* pH(i) . Regulation SLC9A1 SLC9A2 12474076 1023515 The results obtained strongly suggest that NHE-1 and NHE-2 are expressed in the basolateral membrane but that they have different roles : [NHE-1] is responsible for pHi recovery after an acid load and is mainly *involved* in steady-state pHi and cell volume regulation . Regulation SLC9A2 EGF 11443049 833681 To understand the mechanism of this regulation , we developed the rat intestinal epithelial ( RIE ) cell as an in vitro model to study the *effect* of on [NHE2] gene expression . Regulation SLC9A2 EGR1 15976391 1452525 Zinc finger transcription factor is *involved* in stimulation of [NHE2] gene expression by phorbol 12-myristate 13-acetate . Regulation SLC9A2 EGR1 15976391 1452530 Our data indicate that may *play* a key role in regulated expression of the human [NHE2] gene . Regulation SLC9A2 PIK3C3 11698263 877816 Unlike that of NHE3 , basal [NHE2] transport activity was not *affected* by inhibition and did not appear to be localized in the juxtanuclear recycling endosome . Regulation SLC9A2 PIK3R4 11698263 877817 Unlike that of NHE3 , basal [NHE2] transport activity was not *affected* by inhibition and did not appear to be localized in the juxtanuclear recycling endosome . Regulation SLC9A2 SLC9A1 11447025 835466 We conclude that in rabbit gastric epithelium , and NHE4 regulate cell volume and NHE1 and [NHE2] *regulate* pH(i) . Regulation SLC9A2 SLC9A4 11447025 835467 We conclude that in rabbit gastric epithelium , NHE1 and regulate cell volume and NHE1 and [NHE2] *regulate* pH(i) . Regulation SLC9A2 SNAP25 12181191 977528 The effects of SNAP were mediated by the cGMP dependent signal transduction pathway as follows : 1 ) LY-83583 and 1H- ( 1,2,4 ) oxadiazolo ( 4,3-a ) quinoxalin-1-one ( ODQ ) , specific inhibitors of soluble guanylate cyclase , blocked the inhibitory *effect* of on [NHE; 2] ) 8-bromo-cGMP mimicked the effects of SNAP on NHE activity ; Regulation SLC9A2 SP3 17561809 1785916 Sp1 and *control* constitutive expression of the human [NHE2] promoter by interactions with the proximal promoter and the transcription initiation site . Regulation SLC9A2 TNF 20722069 2381270 The studies were designed to determine the *effect* of on the expression and activity of [NHE2] , a Na ( + ) /H ( + ) exchanger ( NHE ) that is involved in transepithelial Na ( + ) absorption in intestinal epithelial cells . Regulation SLC9A3 ADRB2 9560162 500339 Mutation of the final residue of the beta2-adrenergic receptor from leucine to alanine abolishes the receptor 's interaction with NHERF and also markedly alters *regulation* of [NHE3] in cells without altering receptor mediated activation of adenylyl cyclase . Regulation SLC9A3 EPHB2 12081562 958407 *Role* of c-SRC and in acid induced activation of [NHE3] . Regulation SLC9A3 PDZK1 17395628 1748529 This study was undertaken to understand the physiological *role* of in regulating [NHE3] activity in native murine colonic enterocytes . Regulation SLC9A3 SLC9A2 15226406 1268630 It is probable that this is one of the mechanisms by which *affects* rapid regulation of [NHE3] by growth factors and neurohumoral mediators . Regulation SLC9A3 TNF 16760259 1624941 IFN-gamma and *regulate* human [NHE3] gene expression by modulating the Sp family transcription factors in human intestinal epithelial cell line C2BBe1 . Regulation SLC9A3 TNF 17540780 1767332 Involvement of Sp1 and Sp3 in differential *regulation* of human [NHE3] promoter activity by sodium butyrate and . Regulation SLC9A3 TNF 17540780 1767334 In this study , we have investigated the *effect* of sodium butyrate ( NaB ) and on human [NHE3] promoter activity . Regulation SLC9A3 TNF 17540780 1767347 Our data suggest that the differential *regulation* of [NHE3] gene expression by NaB and is mediated through alternative pathways that converge on Sp1/Sp3 . Regulation SLC9A3 TNF 18785066 2012162 These findings suggest a *role* of in the regulation of [NHE-3] expression in IBD . Regulation SLC9A3R1 EPHB2 17107942 1700429 We conclude that phosphorylation in distal kidney cells by PTH requires PTH1R activation of G ( i ) , which leads to stimulation of metalloprotease mediated cleavage of HB-EGF and transactivation of the EGFR and is *regulated* by [EBP50] . Regulation SLC9A4 SLC9A2 11447025 835469 We conclude that in rabbit gastric epithelium , NHE1 and [NHE4] regulate cell volume and NHE1 and *regulate* pH(i) . Regulation SLCO6A1 TNFSF10 23178631 2704332 The *effect* of on the expression of multidrug resistant genes MDR1 , LRP and [GST-p] in drug-resistant gastric cancer cell SGC7901/VCR . Regulation SLPI ARSA 11598899 870537 Here we tested this hypothesis by studying the [ALP-inductive] *response* of normal human gingival fibroblasts to . Regulation SLPI ARSA 11598899 870547 These results indicate that the ECM regulates the induction of ALP expression by AsA in fibroblasts : FN enables them to express [ALP] in *response* to through interaction with integrin alpha 5 beta 1 , whereas type I collagen fibrils cause the suppression of ALP expression and overcome FN . Regulation SLPI ARSA 8086852 271409 The *effects* of on [ALP] activity and DNA content were not coupled to its effect on collagen synthesis , raising the question of whether AsA action is matrix mediated . Regulation SLPI EPHB2 15013846 1220728 The data presented in this study support the conclusion that , in MG-63 osteoblasts ( i ) the increase in [ALP] activity by flavonols *involves* a rapid stimulation of activation but also involves the ER , and that ( ii ) the activation of ERK by flavonols occurs most likely downstream of the ERs activation . Regulation SLPI FOXO1 11786925 901327 In this study , we examined the expression of forkhead transcription factor , a regulator of hepatic glucose metabolic and proapoptotic genes , in osteogenic cells and the *effect* of FKHR on transcription of the [ALP] gene . Regulation SLPI IL1B 8020864 262893 We examined the *effect* of tumor necrosis factor alpha (TNF-alpha) , and IL-6 on [alkaline phosphatase (ALP)] and osteocalcin (OC) production , calcification and calcium ( Ca ) release in human cultured osteoblastic cells established from human periosteum . Regulation SLPI IL1B 8156283 253245 We examined the *effect* of TNF-alpha , and IL-6 on [alkaline phosphatase (ALP)] and osteocalcin (OC) production , calcification and calcium ( Ca ) release in human osteoblastic cell cultures obtained from human periosteum . Regulation SLPI IL1B 8222965 232312 The present study showed the *effect* of on liver/bone/kidney ( L/B/K ) [alkaline phosphatase (ALP)] mRNA level of the fibroblastic cells derived from human periodontal ligament ( HPLF ) . Regulation SLPI IL1B 9213003 441535 alone had no *effect* on [ALP] activity , but it significantly enhanced BMP-2- and -4-induced ALP activity . Regulation SLPI TNF 16728240 1565618 *Regulation* of [ALP] activity by on human dental pulp . Regulation SLPI TNF 16728240 1565636 In this study , we examined the *effects* of on Bone morphogenetic protein ( BMP-2 ) , Smads ( which play intracellular signaling of BMPs ) expression and [alkaline phosphatase (ALP)] activity of human dental pulp ( HDP ) cells to clarify the mechanism of tertiary dentin formation . Regulation SLPI TNF 16728240 1565640 These results suggest that NF- kappaB and Smad7 play an important role in the down *regulation* of [ALP] activity by on HDP cells . Regulation SLPI TNF 17114478 1651567 The tumor promoting *effect* of involves the induction of [secretory leukocyte protease inhibitor] . Regulation SLPI TNF 23657597 2819241 The functional *role* of and IL-1ß in increasing the [ALP] activity and mineralization of periosteal derived cells primarily depends on the JNK signaling among the MAPK pathways . Regulation SLPI TNF 8088923 271677 does not significantly *affect* the activity or mRNA levels of [ALP] . Regulation SLPI TNF 9213003 441525 The modulatory *effects* of interleukin (IL)-1 beta and on bone morphogenetic protein (BMP)-2- and -4-induced [alkaline phosphatase (ALP)] activity were examined in cultures of mouse MC3T3-E1 osteoblastic cells . Regulation SMAD1 CTGF 20522428 2271260 CONCLUSIONS These findings provide the first evidence that variants within the promoter region of the CTGF/CCN2 gene predisposes diabetic subjects to develop albuminuria and demonstrate that [Smad1] [ corrected ] *controls* the expression of promoter through this region . Regulation SMAD1 EPHB2 12368229 1019237 does not directly *affect* [SMAD] signaling . Regulation SMAD1 EPHB2 17418380 1748758 These increases occur as TGF-beta1 downregulates IL-13 induced phosphoinositide-3 kinase activation while leaving the positive *effect* of IL-13 induced on [Smad] signaling . Regulation SMAD1 MAP2K6 12368229 1019245 does not directly *affect* [SMAD] signaling . Regulation SMAD1 TNF 17266397 1725638 The *effect* of induced NF-kappaB signaling on [Smad] signaling and on in vitro osteoblast mineralization was examined using specific NF-kappaB inhibitors and activators , and effects of TNFalpha induced NF-kappaB signaling on BMP-2 induced Runx2 mRNA were examined using RT-PCR . Regulation SMAD2 CLU 18082619 1854648 , a novel modulator of TGF-beta signaling , is *involved* in [Smad2/3] stability . Regulation SMAD2 CLU 18082619 1854652 We also found that was *involved* in [Smad2/3] stability at the protein level . Regulation SMAD2 EPHB2 12368229 1019248 does not directly *affect* [SMAD] signaling . Regulation SMAD2 EPHB2 12824291 1113606 This effect was not seen in the mouse mammary epithelial NMuMG cell line , indicating that *dependent* activation of [Smad2/3] occurs only in certain cell types . Regulation SMAD2 EPHB2 12824291 1113651 These results indicate that *dependent* [R-Smad] linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells . Regulation SMAD2 EPHB2 17002919 1618165 TGF-beta activates extracellular signal regulated kinase ( ERK ) in mesangial cells , and is *involved* in activation of [Smad2/3] . Regulation SMAD2 EPHB2 17418380 1748759 These increases occur as TGF-beta1 downregulates IL-13 induced phosphoinositide-3 kinase activation while leaving the positive *effect* of IL-13 induced on [Smad] signaling . Regulation SMAD2 EPHB2 23295196 2798675 Moreover , exogenous AngII resulted in increases in [Smad2] activation and MMP-9 production , in an *dependent* manner . Regulation SMAD2 MAP2K6 12368229 1019256 does not directly *affect* [SMAD] signaling . Regulation SMAD2 MAP2K6 19413895 2120128 In addition , CREG expression blocked fibrosis and collagen synthesis through blocking *dependent* [Smad 2/3] activation in vitro and in vivo . Regulation SMAD2 TNF 17266397 1725641 The *effect* of induced NF-kappaB signaling on [Smad] signaling and on in vitro osteoblast mineralization was examined using specific NF-kappaB inhibitors and activators , and effects of TNFalpha induced NF-kappaB signaling on BMP-2 induced Runx2 mRNA were examined using RT-PCR . Regulation SMAD3 CLU 18082619 1854649 , a novel modulator of TGF-beta signaling , is *involved* in [Smad2/3] stability . Regulation SMAD3 CLU 18082619 1854653 We also found that was *involved* in [Smad2/3] stability at the protein level . Regulation SMAD3 EPHB2 12368229 1019259 does not directly *affect* [SMAD] signaling . Regulation SMAD3 EPHB2 12824291 1113607 This effect was not seen in the mouse mammary epithelial NMuMG cell line , indicating that *dependent* activation of [Smad2/3] occurs only in certain cell types . Regulation SMAD3 EPHB2 12824291 1113652 These results indicate that *dependent* [R-Smad] linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells . Regulation SMAD3 EPHB2 17002919 1618166 TGF-beta activates extracellular signal regulated kinase ( ERK ) in mesangial cells , and is *involved* in activation of [Smad2/3] . Regulation SMAD3 EPHB2 17418380 1748760 These increases occur as TGF-beta1 downregulates IL-13 induced phosphoinositide-3 kinase activation while leaving the positive *effect* of IL-13 induced on [Smad] signaling . Regulation SMAD3 EPHB2 20833210 2330862 Increased Jagged1 expression upon TGFß1 exposure required [Smad3] signalling , and was also *regulated* by PI3K and . Regulation SMAD3 MAP2K6 12368229 1019267 does not directly *affect* [SMAD] signaling . Regulation SMAD3 MAP2K6 17197157 1709407 [SMAD3] expression is *regulated* by in epithelial and smooth muscle cells . Regulation SMAD3 MAP2K6 19413895 2120136 In addition , CREG expression blocked fibrosis and collagen synthesis through blocking *dependent* [Smad 2/3] activation in vitro and in vivo . Regulation SMAD3 NEDD9 15051726 1265224 Recent studies suggest that is also *involved* in the transforming growth factor-beta ( TGF-beta ) signaling pathways , by interacting with [Smad3] , a key signal transducer downstream of the TGF-beta type I receptor . Regulation SMAD3 SLC6A2 20547485 2302059 Taken together , our results demonstrate that [Smad3] *regulates* RhoA activation and cytoskeletal reorganization by controlling in TGF-beta1 induced ARPE-19 cells . Regulation SMAD3 TNF 17266397 1725644 The *effect* of induced NF-kappaB signaling on [Smad] signaling and on in vitro osteoblast mineralization was examined using specific NF-kappaB inhibitors and activators , and effects of TNFalpha induced NF-kappaB signaling on BMP-2 induced Runx2 mRNA were examined using RT-PCR . Regulation SMAD4 EPHB2 12368229 1019270 does not directly *affect* [SMAD] signaling . Regulation SMAD4 EPHB2 12824291 1113653 These results indicate that *dependent* [R-Smad] linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells . Regulation SMAD4 EPHB2 17418380 1748761 These increases occur as TGF-beta1 downregulates IL-13 induced phosphoinositide-3 kinase activation while leaving the positive *effect* of IL-13 induced on [Smad] signaling . Regulation SMAD4 MAP2K6 12368229 1019278 does not directly *affect* [SMAD] signaling . Regulation SMAD4 NES 11265759 764497 We then show evidence suggesting that the *dependent* cytoplasmic localization of [Smad4] is important for ensuring optimal TGF-beta responsivenesses in transcriptional activation . Regulation SMAD4 TNF 17266397 1725647 The *effect* of induced NF-kappaB signaling on [Smad] signaling and on in vitro osteoblast mineralization was examined using specific NF-kappaB inhibitors and activators , and effects of TNFalpha induced NF-kappaB signaling on BMP-2 induced Runx2 mRNA were examined using RT-PCR . Regulation SMAD5 EPHB2 12368229 1019281 does not directly *affect* [SMAD] signaling . Regulation SMAD5 EPHB2 17418380 1748762 These increases occur as TGF-beta1 downregulates IL-13 induced phosphoinositide-3 kinase activation while leaving the positive *effect* of IL-13 induced on [Smad] signaling . Regulation SMAD5 MAP2K6 12368229 1019289 does not directly *affect* [SMAD] signaling . Regulation SMAD5 TNF 17266397 1725650 The *effect* of induced NF-kappaB signaling on [Smad] signaling and on in vitro osteoblast mineralization was examined using specific NF-kappaB inhibitors and activators , and effects of TNFalpha induced NF-kappaB signaling on BMP-2 induced Runx2 mRNA were examined using RT-PCR . Regulation SMAD6 EPHB2 12368229 1019292 does not directly *affect* [SMAD] signaling . Regulation SMAD6 EPHB2 17418380 1748763 These increases occur as TGF-beta1 downregulates IL-13 induced phosphoinositide-3 kinase activation while leaving the positive *effect* of IL-13 induced on [Smad] signaling . Regulation SMAD6 MAP2K6 12368229 1019300 does not directly *affect* [SMAD] signaling . Regulation SMAD6 TNF 17266397 1725653 The *effect* of induced NF-kappaB signaling on [Smad] signaling and on in vitro osteoblast mineralization was examined using specific NF-kappaB inhibitors and activators , and effects of TNFalpha induced NF-kappaB signaling on BMP-2 induced Runx2 mRNA were examined using RT-PCR . Regulation SMAD7 CTGF 17498122 1739834 The differential *regulation* of [Smad7] in kidney tubule cells by and transforming growth factor-beta1 . Regulation SMAD7 CTGF 17498122 1739836 The *effect* of on [Smad7] expression and its role in the regulation of Smad7 induced by TGF-beta1 in renal tubular cells is unknown . Regulation SMAD7 EPHB2 11716483 881691 These results indicated that activation negatively *regulated* [Smad7] transcription possibly by inhibiting translocation of Smad complex to nuclei . Regulation SMAD7 EPHB2 12368229 1019303 does not directly *affect* [SMAD] signaling . Regulation SMAD7 EPHB2 17418380 1748764 These increases occur as TGF-beta1 downregulates IL-13 induced phosphoinositide-3 kinase activation while leaving the positive *effect* of IL-13 induced on [Smad] signaling . Regulation SMAD7 MAP2K6 12368229 1019311 does not directly *affect* [SMAD] signaling . Regulation SMAD7 TNF 16728240 1565638 Furthermore , we examined the *effect* of and PDTC on [Smad7] expression using RT-PCR and western blot analysis . Regulation SMAD7 TNF 17266397 1725656 The *effect* of induced NF-kappaB signaling on [Smad] signaling and on in vitro osteoblast mineralization was examined using specific NF-kappaB inhibitors and activators , and effects of TNFalpha induced NF-kappaB signaling on BMP-2 induced Runx2 mRNA were examined using RT-PCR . Regulation SMAD9 EPHB2 12368229 1019314 does not directly *affect* [SMAD] signaling . Regulation SMAD9 EPHB2 17418380 1748765 These increases occur as TGF-beta1 downregulates IL-13 induced phosphoinositide-3 kinase activation while leaving the positive *effect* of IL-13 induced on [Smad] signaling . Regulation SMAD9 MAP2K6 12368229 1019322 does not directly *affect* [SMAD] signaling . Regulation SMAD9 TNF 17266397 1725659 The *effect* of induced NF-kappaB signaling on [Smad] signaling and on in vitro osteoblast mineralization was examined using specific NF-kappaB inhibitors and activators , and effects of TNFalpha induced NF-kappaB signaling on BMP-2 induced Runx2 mRNA were examined using RT-PCR . Regulation SMARCA2 CCND1 21811517 2462627 Moreover , also *regulated* the expression of both [Smarca2-a] and Smarca2-b in a complex manner . Regulation SMARCA4 EPHB2 12824291 1113645 These results indicate that *dependent* [R-Smad] linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells . Regulation SMARCA4 TP63 24346698 2895200 We also show that , in epidermal progenitor cells , directly *regulates* the expression of the ATP dependent chromatin remodeller [Brg1] , which binds to distinct domains within the EDC and is required for relocation of the EDC towards the nuclear interior . Regulation SMARCC1 EPHB2 12824291 1113646 These results indicate that *dependent* [R-Smad] linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells . Regulation SMARCC2 EPHB2 12824291 1113647 These results indicate that *dependent* [R-Smad] linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells . Regulation SMC2 CD14 7532623 292117 We thus investigated the *role* of for stimulation of vascular [SMC] by LPS . Regulation SMC2 CD14 7532623 292127 Since the vascular SMC did not express endogenous CD14 , we investigated the *role* of human serum derived soluble ( sCD14 ) for activation of [SMC] by LPS . Regulation SMC2 CD14 7532623 292137 These results show that specific activation of vascular [SMC] by LPS does not *involve* binding to endogenous membrane , but that the activation of vascular SMC by LPS is mediated to a great extent by serum derived sCD14 . Regulation SMC2 FOXO1 19483080 2107872 In contrast , knockdown of CHIP by small interfering RNA enhanced mediated transactivation and its *effect* on [SMC] proliferation and survival . Regulation SMC2 IL1B 10367601 621371 We also demonstrated that suramin causes cell-surface accumulation of the elastin binding protein , a receptor that not only anchors SMCs to the extracellular matrix , but also inhibits [SMC] *response* to . Regulation SMC2 IL1B 7896895 299967 Thus , our studies suggest that vascular [SMC] fibronectin synthesis is *regulated* by reciprocal induction of and TNF-alpha activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Regulation SMC2 MAP2K6 15217807 1281805 Our data suggest that bFGF induced signal regulated kinase signaling *plays* an antagonistic role in TGFbeta1 induced [SMC] gene expression through suppression of the SRF function . Regulation SMC2 TFPI2 20537494 2284701 Tissue factor pathway inhibitor-2 ( TFPI-2 ) and caspase-3 protein expression was studied in the rat carotid artery after balloon-injury , and the *effect* of on [SMC] DNA synthesis and apoptosis was examined in vitro . Regulation SMC2 TNF 7896895 299966 Thus , our studies suggest that vascular [SMC] fibronectin synthesis is *regulated* by reciprocal induction of IL-1 beta and activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Regulation SMC3 CD14 7532623 292121 We thus investigated the *role* of for stimulation of vascular [SMC] by LPS . Regulation SMC3 CD14 7532623 292131 Since the vascular SMC did not express endogenous CD14 , we investigated the *role* of human serum derived soluble ( sCD14 ) for activation of [SMC] by LPS . Regulation SMC3 CD14 7532623 292141 These results show that specific activation of vascular [SMC] by LPS does not *involve* binding to endogenous membrane , but that the activation of vascular SMC by LPS is mediated to a great extent by serum derived sCD14 . Regulation SMC3 FOXO1 19483080 2107876 In contrast , knockdown of CHIP by small interfering RNA enhanced mediated transactivation and its *effect* on [SMC] proliferation and survival . Regulation SMC3 IL1B 10367601 621375 We also demonstrated that suramin causes cell-surface accumulation of the elastin binding protein , a receptor that not only anchors SMCs to the extracellular matrix , but also inhibits [SMC] *response* to . Regulation SMC3 IL1B 7896895 299975 Thus , our studies suggest that vascular [SMC] fibronectin synthesis is *regulated* by reciprocal induction of and TNF-alpha activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Regulation SMC3 MAP2K6 15217807 1281837 Our data suggest that bFGF induced signal regulated kinase signaling *plays* an antagonistic role in TGFbeta1 induced [SMC] gene expression through suppression of the SRF function . Regulation SMC3 TFPI2 20537494 2284705 Tissue factor pathway inhibitor-2 ( TFPI-2 ) and caspase-3 protein expression was studied in the rat carotid artery after balloon-injury , and the *effect* of on [SMC] DNA synthesis and apoptosis was examined in vitro . Regulation SMC3 TNF 7896895 299974 Thus , our studies suggest that vascular [SMC] fibronectin synthesis is *regulated* by reciprocal induction of IL-1 beta and activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Regulation SMC4 CD14 7532623 292118 We thus investigated the *role* of for stimulation of vascular [SMC] by LPS . Regulation SMC4 CD14 7532623 292128 Since the vascular SMC did not express endogenous CD14 , we investigated the *role* of human serum derived soluble ( sCD14 ) for activation of [SMC] by LPS . Regulation SMC4 CD14 7532623 292138 These results show that specific activation of vascular [SMC] by LPS does not *involve* binding to endogenous membrane , but that the activation of vascular SMC by LPS is mediated to a great extent by serum derived sCD14 . Regulation SMC4 FOXO1 19483080 2107873 In contrast , knockdown of CHIP by small interfering RNA enhanced mediated transactivation and its *effect* on [SMC] proliferation and survival . Regulation SMC4 IL1B 10367601 621372 We also demonstrated that suramin causes cell-surface accumulation of the elastin binding protein , a receptor that not only anchors SMCs to the extracellular matrix , but also inhibits [SMC] *response* to . Regulation SMC4 IL1B 7896895 299969 Thus , our studies suggest that vascular [SMC] fibronectin synthesis is *regulated* by reciprocal induction of and TNF-alpha activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Regulation SMC4 MAP2K6 15217807 1281813 Our data suggest that bFGF induced signal regulated kinase signaling *plays* an antagonistic role in TGFbeta1 induced [SMC] gene expression through suppression of the SRF function . Regulation SMC4 TFPI2 20537494 2284702 Tissue factor pathway inhibitor-2 ( TFPI-2 ) and caspase-3 protein expression was studied in the rat carotid artery after balloon-injury , and the *effect* of on [SMC] DNA synthesis and apoptosis was examined in vitro . Regulation SMC4 TNF 7896895 299968 Thus , our studies suggest that vascular [SMC] fibronectin synthesis is *regulated* by reciprocal induction of IL-1 beta and activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Regulation SMC5 CD14 7532623 292119 We thus investigated the *role* of for stimulation of vascular [SMC] by LPS . Regulation SMC5 CD14 7532623 292129 Since the vascular SMC did not express endogenous CD14 , we investigated the *role* of human serum derived soluble ( sCD14 ) for activation of [SMC] by LPS . Regulation SMC5 CD14 7532623 292139 These results show that specific activation of vascular [SMC] by LPS does not *involve* binding to endogenous membrane , but that the activation of vascular SMC by LPS is mediated to a great extent by serum derived sCD14 . Regulation SMC5 FOXO1 19483080 2107874 In contrast , knockdown of CHIP by small interfering RNA enhanced mediated transactivation and its *effect* on [SMC] proliferation and survival . Regulation SMC5 IL1B 10367601 621373 We also demonstrated that suramin causes cell-surface accumulation of the elastin binding protein , a receptor that not only anchors SMCs to the extracellular matrix , but also inhibits [SMC] *response* to . Regulation SMC5 IL1B 7896895 299971 Thus , our studies suggest that vascular [SMC] fibronectin synthesis is *regulated* by reciprocal induction of and TNF-alpha activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Regulation SMC5 MAP2K6 15217807 1281821 Our data suggest that bFGF induced signal regulated kinase signaling *plays* an antagonistic role in TGFbeta1 induced [SMC] gene expression through suppression of the SRF function . Regulation SMC5 TFPI2 20537494 2284703 Tissue factor pathway inhibitor-2 ( TFPI-2 ) and caspase-3 protein expression was studied in the rat carotid artery after balloon-injury , and the *effect* of on [SMC] DNA synthesis and apoptosis was examined in vitro . Regulation SMC5 TNF 7896895 299970 Thus , our studies suggest that vascular [SMC] fibronectin synthesis is *regulated* by reciprocal induction of IL-1 beta and activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Regulation SMC6 CD14 7532623 292120 We thus investigated the *role* of for stimulation of vascular [SMC] by LPS . Regulation SMC6 CD14 7532623 292130 Since the vascular SMC did not express endogenous CD14 , we investigated the *role* of human serum derived soluble ( sCD14 ) for activation of [SMC] by LPS . Regulation SMC6 CD14 7532623 292140 These results show that specific activation of vascular [SMC] by LPS does not *involve* binding to endogenous membrane , but that the activation of vascular SMC by LPS is mediated to a great extent by serum derived sCD14 . Regulation SMC6 FOXO1 19483080 2107875 In contrast , knockdown of CHIP by small interfering RNA enhanced mediated transactivation and its *effect* on [SMC] proliferation and survival . Regulation SMC6 IL1B 10367601 621374 We also demonstrated that suramin causes cell-surface accumulation of the elastin binding protein , a receptor that not only anchors SMCs to the extracellular matrix , but also inhibits [SMC] *response* to . Regulation SMC6 IL1B 7896895 299973 Thus , our studies suggest that vascular [SMC] fibronectin synthesis is *regulated* by reciprocal induction of and TNF-alpha activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Regulation SMC6 MAP2K6 15217807 1281829 Our data suggest that bFGF induced signal regulated kinase signaling *plays* an antagonistic role in TGFbeta1 induced [SMC] gene expression through suppression of the SRF function . Regulation SMC6 TFPI2 20537494 2284704 Tissue factor pathway inhibitor-2 ( TFPI-2 ) and caspase-3 protein expression was studied in the rat carotid artery after balloon-injury , and the *effect* of on [SMC] DNA synthesis and apoptosis was examined in vitro . Regulation SMC6 TNF 7896895 299972 Thus , our studies suggest that vascular [SMC] fibronectin synthesis is *regulated* by reciprocal induction of IL-1 beta and activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production . Regulation SMN1 EPHB2 16598650 1544949 Based on these findings , we conclude that p38 kinase , , and AP-1 are *responsible* for the [alpha-SMA] expression induced by TGF-beta1 in human fetal lung fibroblasts . Regulation SMN1 EPHB2 16598650 1544951 is *involved* in inducing [alpha-SMA] expression via AP-1 activation . Regulation SMN1 IL1B 15383601 1298978 Because IL-1beta can induce C/EBPbeta expression , the role of C/EBPbeta isoforms in *regulation* of [alpha-SMA] gene expression was investigated in rat lung myofibroblasts . Regulation SMN1 SMN2 12411585 1010920 We described previously the *effect* of heteroduplex formation on SMN gene dosage analysis , which is a multiplex quantitative PCR assay to determine the copy numbers of [SMN1] and SMN2 using DraI digestion to differentiate SMN2 from SMN1 . Regulation SMN1 SMN2 22324632 2576125 At present , the *role* of in [SMA] is unknown . Regulation SMN2 DDX20 10767334 684931 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Regulation SMN2 GEMIN2 10767334 684923 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Regulation SMN2 GEMIN4 10767334 684927 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Regulation SMN2 GEMIN5 10767334 684928 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Regulation SMN2 GEMIN6 10767334 684929 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Regulation SMN2 GEMIN7 10767334 684930 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Regulation SMN2 HDAC1 18345520 1938078 These results suggest that EBV transformed lymphoblastoid cell lines are not suitable for studying the *effect* of certain inhibitors on [SMN2] gene expression . Regulation SMN2 HDAC2 18345520 1938079 These results suggest that EBV transformed lymphoblastoid cell lines are not suitable for studying the *effect* of certain inhibitors on [SMN2] gene expression . Regulation SMN2 IRF1 11147573 760999 is , therefore , at least in part *responsible* for the induction of [SMN] and SMNc by IFNs . Regulation SMN2 MAP3K5 21496457 2422949 Collectively , our results suggest that acts as a novel binding partner of SMN and *controls* the steady-state level of [SMN] through complex formation with SMN in neurite outgrowth . Regulation SMN2 NPY4R 22454514 2637037 A *role* for protein phosphatase in [SMN complex] formation and subnuclear localization to Cajal bodies . Regulation SMN2 NPY4R 22454514 2637096 Our findings reveal a *role* of in the formation of the [SMN complex] and the maintenance of CB integrity . Regulation SMN2 RBBP4 18345520 1938080 These results suggest that EBV transformed lymphoblastoid cell lines are not suitable for studying the *effect* of certain inhibitors on [SMN2] gene expression . Regulation SMN2 RBBP7 18345520 1938081 These results suggest that EBV transformed lymphoblastoid cell lines are not suitable for studying the *effect* of certain inhibitors on [SMN2] gene expression . Regulation SMN2 SMN1 12411585 1010921 We described previously the *effect* of heteroduplex formation on SMN gene dosage analysis , which is a multiplex quantitative PCR assay to determine the copy numbers of SMN1 and [SMN2] using DraI digestion to differentiate SMN2 from SMN1 . Regulation SMN2 SMN1 20523126 2345335 Thus [SMN2] is a prime therapeutic *target* for . Regulation SMN2 SMN2 10767334 684924 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Regulation SMN2 SNRPA 10767334 684925 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Regulation SMN2 SNRPB 10767334 684926 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Regulation SMN2 STAT5A 17220171 1709740 Knockdown of Stat5 expression disrupted the effects of sodium vanadate on SMN2 activation but did not influence SMN2 splicing , suggesting that signaling is *involved* in [SMN2] transcriptional regulation . Regulation SMN2 STRAP 10767334 684932 We suggest that the interaction between [SMN] and DP103 is further evidence for a role for SMN in transcriptional regulation and that may be *involved* in the regulation of neuron-specific genes essential in neuronal development . Regulation SMPD1 FAS 11255263 794229 *Involvement* of receptor and not tumor necrosis factor-alpha receptor in ultraviolet induced activation of [acid sphingomyelinase] . Regulation SMPD2 IL1B 10704249 672804 IL-1beta ( human , recombinant ) was shown to activate , in a dose dependent manner , nSMase in the P ( 2 ) brain fraction of the wild-type mice while in the knock-out mice the stimulatory *effect* of on [nSMase] was absent . Regulation SMPD2 TNF 10359574 619106 Inhibition of the TNFR-I/FAN ( factor associated with neutral sphingomyelinase ) interaction , which is essential for *dependent* activation of the [neutral sphingomyelinase] , either by cell-permeable peptides or by deletion of the FAN binding domain , prevents activation of c-Raf-1 kinase . Regulation SMPD2 TNF 18653803 1960506 *Regulation* of [neutral sphingomyelinase-2 (nSMase2)] by involves protein kinase C-delta in lung epithelial cells . Regulation SMPD3 EPHB2 17085432 1675787 Furthermore , the translocation of [nSMase2] was *regulated* by p38-alpha MAPK , but not or JNK , and the increase in endogenous N-SMase activity was abrogated by p38 MAPK inhibition . Regulation SMPD3 TNF 20080539 2205772 After knockdown of EED by RNA interference , the *dependent* activation of [nSMase2] is completely abrogated , identifying EED as a protein that both physically and functionally couples TNF-R1 to nSMase2 , and which therefore represents the `` missing link '' that completes one of the last unresolved signaling pathways of TNF-R1 . Regulation SNAI1 VSNL1 22479362 2578863 These findings indicate that is *involved* in EMT of SCC by regulating the transcription factor [Snail1] in a cAMP dependent manner . Regulation SNAI2 EPHB2 24130883 2853367 Upstream PTEN/Akt , mTOR , , and AR/Hsp90 pathways were *responsible* for [Slug] up-regulation and each of these could be targeted by rapamycin , CI-1040 , and 17-AAG respectively . Regulation SNAI2 TNF 23339680 2738492 In the study , we designed to investigate the *effect* of on the activation and expression of nuclear factor kappa B ( NF-?B ) [/p65/SLUG/PUMA/Bcl-2] levels in human lung cancer A549 cell line , and in conditions of TNF-a induced apoptosis . Regulation SNCA PTGER2 17204153 1681259 We investigated the *role* of prostaglandin in [alpha-synuclein] aggregation induced microglial activation using ex vivo , in vivo and in vitro experimental systems . Regulation SNCA SNCAIP 10762166 683373 Our data suggest that could *play* a role in [Lewy body] formation and the pathogenesis of PD . Regulation SNCA SNCAIP 17467279 1743428 Since both parkin and have been *involved* in [Lewy body (LB)] formation , we decided to explore whether their isoforms are differentially expressed in LB diseases . Regulation SNCA TF 14742448 1226184 We investigated the *role* of and iron in modulating the expression of [alpha-synuclein] ( alpha-syn ) in MPP ( + ) -induced oxidative stress and apoptosis . Regulation SNCAIP CSNK2A1 14645218 1201646 phosphorylation *regulates* [alpha-synuclein/synphilin-1] interaction and inclusion body formation . Regulation SNCAIP CSNK2A2 14645218 1201647 phosphorylation *regulates* [alpha-synuclein/synphilin-1] interaction and inclusion body formation . Regulation SNCAIP CSNK2B 14645218 1201648 phosphorylation *regulates* [alpha-synuclein/synphilin-1] interaction and inclusion body formation . Regulation SNCG EPHB2 17016652 1630010 *Involvement* of RHO GTPases and in [synuclein-gamma] enhanced cancer cell motility . Regulation SNRK CABP4 21098029 2383311 Here , we report that [SnRK2s] interact with and are *regulated* by a plant-specific . Regulation SOAT1 EPHB2 9872331 556882 We investigated the *role* of on the regulation of [STAT] activity . Regulation SOAT1 IL6R 11468177 840877 Neutralizing monoclonal antibodies against IL-6 , , gp130 , or both receptor subunits did not *affect* the proliferation or the constitutive activation of [STAT] molecules in HD cell lines . Regulation SOCS1 TNF 17059693 1637156 Nitric oxide induces [SOCS-1] expression in human monocytes in a *dependent* manner . Regulation SOCS1 TNF 19561639 2129019 In Jurkat T cells and mouse splenocytes , we have found that [SOCS1] is induced in *response* to or H ( 2 ) O ( 2 ) , concomitant with the activation of Jaks which act as important mediators of reactive oxygen species ( ROS ) -induced apoptosis upstream of p38 mitogen activated protein kinase . Regulation SOCS1 TNF 23375208 2747879 Nasal epithelial cell culture was used to elucidate the *effect* of IL-4 , IL-5 , IL-6 , IL-10 , IL-13 , IFN-? , , and TGF-ß1 on [SOCS1] and SOCS3 expression in sinus mucosa . Regulation SOCS2 TNF 18820827 1987675 These data suggest that CIS can serve as an SLE disease marker and may be involved in the pathogenesis of SLE , and that may *play* an important role in the regulation of CIS and [SOCS2] gene expression in PBMCs in vivo . Regulation SOCS3 EPHB2 22311708 2580502 In addition AP-1 , pSTAT , and SP1/SP3 binding sites were required for *dependent* , PMA stimulated [SOCS-3] gene activation . Regulation SOCS3 TNF 17312125 1699659 *Regulation* of [suppressor of cytokine signaling 3] ( SOCS3 ) mRNA stability by involves activation of the MKK6/p38MAPK/MK2 cascade . Regulation SOCS3 TNF 17312125 1699666 In summary , these data indicate that *regulates* [SOCS3] expression on the level of mRNA stability via activation of the MKK6/p38 ( MAPK ) cascade and that the activation of MK2 , a downstream target of p38 ( MAPK ) , is important for the regulation of SOCS3 expression . Regulation SOCS3 TNF 23375208 2747883 Nasal epithelial cell culture was used to elucidate the *effect* of IL-4 , IL-5 , IL-6 , IL-10 , IL-13 , IFN-? , , and TGF-ß1 on SOCS1 and [SOCS3] expression in sinus mucosa . Regulation SOD1 ABCA12 7696980 288079 The *effect* of chlorpromazine and on the [superoxide dismutase] and glutathione peroxidase activities of rat brain , liver and erythrocytes . Regulation SOD1 ARSA 11557525 861364 IEC-6 and IRD-98 , nontransformed rat small intestinal epithelial cell lines , were used to examine the *effect* of <5-ASA> on the expression of manganese [superoxide dismutase] ( MnSOD ) . Regulation SOD1 ARSA 15825433 1352855 In order to know more about the relationships between photosynthesis photoinhibition and reactive oxygen species metabolism , the *effects* of 6-benzyladenine ( 6-BA ) and on net photosynthetic rate ( Pn ) , apparent quantum yield ( AQY ) , [superoxide dismutase (SOD)] and ascorbate peroxidase ( APX ) activities , O2-* generation rate , and H2O2 and malondialdehyde ( MDA ) contents were studied with attached leaves of poplar clone seedlings under osmotic stress of root . Regulation SOD1 IL1B 10912627 714005 The object of this study was to assess the *effects* of the inflammatory cytokine ( 0.01-1.0 ng/ml ) on the activity of catalase (CAT) , [superoxide dismutase (SOD)] and the level of glutathione ( GSH ) , all being antioxidant mechanisms , in human peritoneal mesothelial cells ( HPMC ) in in vitro culture . Regulation SOD1 IL1B 1533363 186502 Presently , the *effects* of human recombinant ( rIL-1 beta ) on the activities of [superoxide dismutase (SOD)] and the expression of corresponding genes were studied in rat pancreatic islets . Regulation SOD1 IL1B 9038369 415560 These results suggest that and TNF-alpha *regulate* [Mn-SOD] gene transcription by different pathways . Regulation SOD1 IL1B 9372929 464429 Tumor necrosis factor alpha and *regulate* the murine manganese [superoxide dismutase] gene through a complex intronic enhancer involving C/EBP-beta and NF-kappaB . Regulation SOD1 IL1B 9473516 486399 However , under basal conditions had no significant *effect* on [ALS] mRNA levels , and only a slight suppression of secretion . Regulation SOD1 IL1B 9473516 486401 Our study suggests that *regulates* [ALS] gene expression and secretion in a way that is dependent , in part , on interaction with the GH signalling pathway . Regulation SOD1 TNF 11675473 873372 The present study was undertaken to investigate the *effect* of on [superoxide dismutase (SOD)] expression in human endometrial stromal cells ( ESC ) and to determine whether there is a difference in responsiveness to TNFalpha between ESC and decidualized ESC . Regulation SOD1 TNF 11675473 873381 had no *effect* on [copper-zinc-SOD] ( Cu , Zn-SOD ) expression in either type of cell . Regulation SOD1 TNF 12684509 1099800 Two regulatory regions , the proximal promoter region ( PPR ) , which is upstream from the transcription initiation site , and the , which is inside intron 2 , are *responsible* for [Mn-SOD] expression . Regulation SOD1 TNF 1311566 179003 *Effects* of , Interleukin-1 (IL-1) , Interleukin-6 (IL-6) and Interferon-gamma (IFN-gamma) on the expression of [Mn-superoxide dismutase] ( Mn-SOD ) protein were investigated in human hepatoma cells , Hu-H1 , which revealed resistance to the cytotoxicity of TNF and IL-1 . Regulation SOD1 TNF 16895791 1597328 A JNK inhibitor antagonized the negative effects of TNF-alpha on SOD1 promoter activity , suggesting that JNK signaling through c-Jun protein activation is critical for the *dependent* [SOD1] repression . Regulation SOD1 TNF 17015957 1629944 Infliximab neutralizes the suppressive *effect* of on expression of [extracellular-superoxide dismutase] in vitro . Regulation SOD1 TNF 1850207 155526 We studied the *effects* of ( TNF-alpha ) , a macrophage derived cytokine , on [Mn-SOD] expression in human pulmonary adenocarcinoma cells . Regulation SOD1 TNF 2406241 128072 *Regulation* of manganese [superoxide dismutase] by lipopolysaccharide , interleukin-1 , and . Regulation SOD1 TNF 2406241 128240 We have demonstrated a dramatic induction of manganese [superoxide dismutase] ( Mn-SOD ) mRNA levels in *response* to lipopolysaccharide (LPS) , interleukin-1 , and in pulmonary epithelial cells . Regulation SOD1 TNF 7487113 332019 Differential *regulation* of manganese [superoxide dismutase] activity by alcohol and in human hepatoma cells . Regulation SOD1 TNF 8857257 388306 To determine whether lipopolysaccharide (LPS) and are *involved* in the induction of [superoxide dismutase (SOD)] in gingival tissue , we examined their effect on induction of SOD isozymes in cultured normal ( NGF ) and phenytoin induced hyperplastic ( PHF ) gingival fibroblasts . Regulation SOD1 TNF 9038369 415559 These results suggest that IL-1beta and *regulate* [Mn-SOD] gene transcription by different pathways . Regulation SOD1 TNF 9651816 515590 Using SV40 transformed human keratinocytes ( SVHK cells ) , we investigated the *effects* of anti-Fas antibody and on the [SOD] activity . Regulation SOD2 ABCA12 7696980 288081 The *effect* of chlorpromazine and on the [superoxide dismutase] and glutathione peroxidase activities of rat brain , liver and erythrocytes . Regulation SOD2 ALOX5 24226420 2926623 Similar to 5-LO ( -/- ) mice , induction of HO-1 , but not [superoxide dismutase-2 (SOD-2)] , was also observed in *response* to <5-LO> ( AA861 ) or 5-LO activating protein ( MK886 ) inhibitors . Regulation SOD2 ARSA 11557525 861365 IEC-6 and IRD-98 , nontransformed rat small intestinal epithelial cell lines , were used to examine the *effect* of <5-ASA> on the expression of manganese [superoxide dismutase] ( MnSOD ) . Regulation SOD2 ARSA 15825433 1352856 In order to know more about the relationships between photosynthesis photoinhibition and reactive oxygen species metabolism , the *effects* of 6-benzyladenine ( 6-BA ) and on net photosynthetic rate ( Pn ) , apparent quantum yield ( AQY ) , [superoxide dismutase (SOD)] and ascorbate peroxidase ( APX ) activities , O2-* generation rate , and H2O2 and malondialdehyde ( MDA ) contents were studied with attached leaves of poplar clone seedlings under osmotic stress of root . Regulation SOD2 IL1B 10912627 714006 The object of this study was to assess the *effects* of the inflammatory cytokine ( 0.01-1.0 ng/ml ) on the activity of catalase (CAT) , [superoxide dismutase (SOD)] and the level of glutathione ( GSH ) , all being antioxidant mechanisms , in human peritoneal mesothelial cells ( HPMC ) in in vitro culture . Regulation SOD2 IL1B 1533363 186503 Presently , the *effects* of human recombinant ( rIL-1 beta ) on the activities of [superoxide dismutase (SOD)] and the expression of corresponding genes were studied in rat pancreatic islets . Regulation SOD2 IL1B 9038369 415562 These results suggest that and TNF-alpha *regulate* [Mn-SOD] gene transcription by different pathways . Regulation SOD2 IL1B 9372929 464430 Tumor necrosis factor alpha and *regulate* the murine manganese [superoxide dismutase] gene through a complex intronic enhancer involving C/EBP-beta and NF-kappaB . Regulation SOD2 TNF 11675473 873373 The present study was undertaken to investigate the *effect* of on [superoxide dismutase (SOD)] expression in human endometrial stromal cells ( ESC ) and to determine whether there is a difference in responsiveness to TNFalpha between ESC and decidualized ESC . Regulation SOD2 TNF 11675473 873382 had no *effect* on [copper-zinc-SOD] ( Cu , Zn-SOD ) expression in either type of cell . Regulation SOD2 TNF 12684509 1099801 Two regulatory regions , the proximal promoter region ( PPR ) , which is upstream from the transcription initiation site , and the , which is inside intron 2 , are *responsible* for [Mn-SOD] expression . Regulation SOD2 TNF 1311566 179006 *Effects* of , Interleukin-1 (IL-1) , Interleukin-6 (IL-6) and Interferon-gamma (IFN-gamma) on the expression of Mn-superoxide dismutase ( [Mn-SOD] ) protein were investigated in human hepatoma cells , Hu-H1 , which revealed resistance to the cytotoxicity of TNF and IL-1 . Regulation SOD2 TNF 17015957 1629945 Infliximab neutralizes the suppressive *effect* of on expression of [extracellular-superoxide dismutase] in vitro . Regulation SOD2 TNF 1850207 155527 We studied the *effects* of tumor necrosis factor ( ) , a macrophage derived cytokine , on [Mn-SOD] expression in human pulmonary adenocarcinoma cells . Regulation SOD2 TNF 2406241 128100 *Regulation* of manganese [superoxide dismutase] by lipopolysaccharide , interleukin-1 , and . Regulation SOD2 TNF 2406241 128268 We have demonstrated a dramatic induction of manganese [superoxide dismutase] ( Mn-SOD ) mRNA levels in *response* to lipopolysaccharide (LPS) , interleukin-1 , and in pulmonary epithelial cells . Regulation SOD2 TNF 7487113 332020 Differential *regulation* of manganese [superoxide dismutase] activity by alcohol and in human hepatoma cells . Regulation SOD2 TNF 8857257 388307 To determine whether lipopolysaccharide (LPS) and are *involved* in the induction of [superoxide dismutase (SOD)] in gingival tissue , we examined their effect on induction of SOD isozymes in cultured normal ( NGF ) and phenytoin induced hyperplastic ( PHF ) gingival fibroblasts . Regulation SOD2 TNF 9038369 415561 These results suggest that IL-1beta and *regulate* [Mn-SOD] gene transcription by different pathways . Regulation SOD2 TNF 9651816 515591 Using SV40 transformed human keratinocytes ( SVHK cells ) , we investigated the *effects* of anti-Fas antibody and on the [SOD] activity . Regulation SOD3 ABCA12 7696980 288083 The *effect* of chlorpromazine and on the [superoxide dismutase] and glutathione peroxidase activities of rat brain , liver and erythrocytes . Regulation SOD3 ARSA 11557525 861366 IEC-6 and IRD-98 , nontransformed rat small intestinal epithelial cell lines , were used to examine the *effect* of <5-ASA> on the expression of manganese [superoxide dismutase] ( MnSOD ) . Regulation SOD3 ARSA 15825433 1352857 In order to know more about the relationships between photosynthesis photoinhibition and reactive oxygen species metabolism , the *effects* of 6-benzyladenine ( 6-BA ) and on net photosynthetic rate ( Pn ) , apparent quantum yield ( AQY ) , [superoxide dismutase (SOD)] and ascorbate peroxidase ( APX ) activities , O2-* generation rate , and H2O2 and malondialdehyde ( MDA ) contents were studied with attached leaves of poplar clone seedlings under osmotic stress of root . Regulation SOD3 EPHB2 21417786 2416628 Moreover , pre-treatment with U0126 , an inhibitor of mitogen activated protein kinase kinase ( MEK ) /ERK , suppressed thapsigargin triggered EC-SOD reduction , suggesting that signalling should *play* an important role in the regulation of [EC-SOD] in COS7 cells under ER stress conditions . Regulation SOD3 IL1B 10912627 714007 The object of this study was to assess the *effects* of the inflammatory cytokine ( 0.01-1.0 ng/ml ) on the activity of catalase (CAT) , [superoxide dismutase (SOD)] and the level of glutathione ( GSH ) , all being antioxidant mechanisms , in human peritoneal mesothelial cells ( HPMC ) in in vitro culture . Regulation SOD3 IL1B 1533363 186504 Presently , the *effects* of human recombinant ( rIL-1 beta ) on the activities of [superoxide dismutase (SOD)] and the expression of corresponding genes were studied in rat pancreatic islets . Regulation SOD3 IL1B 9038369 415564 These results suggest that and TNF-alpha *regulate* [Mn-SOD] gene transcription by different pathways . Regulation SOD3 IL1B 9372929 464431 Tumor necrosis factor alpha and *regulate* the murine manganese [superoxide dismutase] gene through a complex intronic enhancer involving C/EBP-beta and NF-kappaB . Regulation SOD3 MAP2K6 21417786 2416634 Moreover , pre-treatment with U0126 , an inhibitor of mitogen activated protein kinase kinase ( MEK ) /ERK , suppressed thapsigargin triggered EC-SOD reduction , suggesting that signalling should *play* an important role in the regulation of [EC-SOD] in COS7 cells under ER stress conditions . Regulation SOD3 TNF 11675473 873374 The present study was undertaken to investigate the *effect* of on [superoxide dismutase (SOD)] expression in human endometrial stromal cells ( ESC ) and to determine whether there is a difference in responsiveness to TNFalpha between ESC and decidualized ESC . Regulation SOD3 TNF 11675473 873383 had no *effect* on [copper-zinc-SOD] ( Cu , Zn-SOD ) expression in either type of cell . Regulation SOD3 TNF 12684509 1099802 Two regulatory regions , the proximal promoter region ( PPR ) , which is upstream from the transcription initiation site , and the , which is inside intron 2 , are *responsible* for [Mn-SOD] expression . Regulation SOD3 TNF 1311566 179009 *Effects* of , Interleukin-1 (IL-1) , Interleukin-6 (IL-6) and Interferon-gamma (IFN-gamma) on the expression of Mn-superoxide dismutase ( [Mn-SOD] ) protein were investigated in human hepatoma cells , Hu-H1 , which revealed resistance to the cytotoxicity of TNF and IL-1 . Regulation SOD3 TNF 17015957 1629946 Infliximab neutralizes the suppressive *effect* of on expression of [extracellular-superoxide dismutase] in vitro . Regulation SOD3 TNF 17015957 1629947 In this report , we investigated the *effect* of on the expression of [EC-SOD] in cultured cells and the cooperating effect of infliximab . Regulation SOD3 TNF 1850207 155528 We studied the *effects* of ( TNF-alpha ) , a macrophage derived cytokine , on [Mn-SOD] expression in human pulmonary adenocarcinoma cells . Regulation SOD3 TNF 2406241 128128 *Regulation* of manganese [superoxide dismutase] by lipopolysaccharide , interleukin-1 , and . Regulation SOD3 TNF 2406241 128296 We have demonstrated a dramatic induction of manganese [superoxide dismutase] ( Mn-SOD ) mRNA levels in *response* to lipopolysaccharide (LPS) , interleukin-1 , and in pulmonary epithelial cells . Regulation SOD3 TNF 7487113 332021 Differential *regulation* of manganese [superoxide dismutase] activity by alcohol and in human hepatoma cells . Regulation SOD3 TNF 8857257 388308 To determine whether lipopolysaccharide (LPS) and are *involved* in the induction of [superoxide dismutase (SOD)] in gingival tissue , we examined their effect on induction of SOD isozymes in cultured normal ( NGF ) and phenytoin induced hyperplastic ( PHF ) gingival fibroblasts . Regulation SOD3 TNF 9038369 415563 These results suggest that IL-1beta and *regulate* [Mn-SOD] gene transcription by different pathways . Regulation SOD3 TNF 9651816 515592 Using SV40 transformed human keratinocytes ( SVHK cells ) , we investigated the *effects* of anti-Fas antibody and on the [SOD] activity . Regulation SORBS1 EPHB2 20440482 2288110 Ca ( OH ) ( 2 ) stimulated expression of the cementum-specific proteins CEMP1 and [PTPLA/CAP] in an *dependent* manner . Regulation SORBS1 IL1B 11980855 934944 The in vitro studies suggest that [CAP37] induction is *regulated* by TNF-alpha and . Regulation SORBS1 TNF 11980855 934943 The in vitro studies suggest that [CAP37] induction is *regulated* by and IL-1beta . Regulation SORL1 PPARA 20970138 2354221 while pre-treatment with a PPAR-? antagonist established a *dependent* role for CLA regulation of [SorLA] . Regulation SORT1 TNF 19219422 2054403 *Involvement* of in abnormal adipocyte and muscle [sortilin] expression in obese mice and humans . Regulation SOS1 EPHB2 20724475 2330216 Here , we used a simulation model based mostly on experimentally determined parameters to study the mediated negative feedback *regulation* of the Ras guanine nucleotide exchange factor , [son of sevenless (SOS)] . Regulation SOS1 JAG1 23613664 2774641 As a corollary , we established that a BER pathway deficient E. coli strain induces [SOS] in *response* to sub-MIC . Regulation SOS1 RNASE1 22719885 2616480 Possible mechanisms for E *effects* on [SOS] are discussed . Regulation SOS1 RNASE7 22719885 2616488 Possible mechanisms for E *effects* on [SOS] are discussed . Regulation SOS2 EPHB2 20724475 2330217 Here , we used a simulation model based mostly on experimentally determined parameters to study the mediated negative feedback *regulation* of the Ras guanine nucleotide exchange factor , [son of sevenless (SOS)] . Regulation SOS2 JAG1 23613664 2774642 As a corollary , we established that a BER pathway deficient E. coli strain induces [SOS] in *response* to sub-MIC . Regulation SOS2 RNASE1 22719885 2616492 Possible mechanisms for E *effects* on [SOS] are discussed . Regulation SOS2 RNASE7 22719885 2616500 Possible mechanisms for E *effects* on [SOS] are discussed . Regulation SOX9 CTGF 17111364 1667649 is also *involved* in up-regulating FN and suppressing [Sox9] expression during TGF-beta1 induced MC condensation . Regulation SOX9 IL1B 20133941 2227002 Transient overexpression of Ank counteracted most of *effects* on Type II collagen , [Sox-9] , and Wnt-5a expression . Regulation SOX9 TNF 18182117 1895189 However , neither agent altered nuclear levels of [Sox9] , and did not *affect* protein binding to the Col2a1 48-base-pair minimal enhancer sequence . Regulation SOX9 TNF 18438857 1915461 The *effect* of on endogenous binding of c/EBPbeta or [SOX9] to the cd-rap promoter was examined by chromatin immunoprecipitation assays . Regulation SOX9 TNF 19144181 2079141 induced *regulation* of [Sox9] and NFkappaB activity was also U0126 insensitive . Regulation SP1 ALOX5 18179798 1937880 In a previous study , a microsatellite polymorphism in the <5-lipoxygenase> gene promoter *involving* the binding site for the [transcription factor Sp1] , was associated with carotid intima media thickness ( CIMT ) . Regulation SP1 EPHB2 14597566 1187453 Helicobacter pylori stimulates host vascular endothelial growth factor-A ( vegf-A ) gene expression via *dependent* activation of [Sp1] and Sp3 . Regulation SP1 EPHB2 18454179 1944652 We propose that Nox1 mediates oncogenic Ras induced upregulation of VEGF and angiogenesis by activating Sp1 through *dependent* phosphorylation of [Sp1] . Regulation SP1 FAS 19621387 2182854 Only [Sp1] , however , also *regulates* . Regulation SP1 MAP2K6 14597566 1187459 Helicobacter pylori stimulates host vascular endothelial growth factor-A ( vegf-A ) gene expression via *dependent* activation of [Sp1] and Sp3 . Regulation SP1 NPNT 21316587 2388695 Moreover , we show that [Sp1 transcription factor] links ERK5 to Klf2/4 , and that , a Klf transcriptional target , is *involved* in muscle cell fusion . Regulation SP1 TNF 11897710 921608 We also assessed the *effect* of , wortmannin , a PI3K inhibitor , and cAMP dependent protein kinase inhibitor on [Sp1] accumulation . Regulation SP1 TNF 17307735 1719114 In parallel , we scanned nine overlapping promoter regions in HaCaT human immortalized keratinocytes using chromatin immunoprecipitation assays to identify binding of mediator , coactivator , and corepressor proteins and [Sp1 transcription factor] in *response* to all-trans-RA and . Regulation SP1 TNF 17626239 1798474 Thus , we provide the first evidence that ES and ES-cell derived vascular cells lack cytokine expression in *response* to stimulation due to low levels of c-fos and transcriptional activation of [Sp1] that can be regulated by inhibition of histone deacetylase activity . Regulation SP100 FOXA1 16214823 1464770 In vitro , *regulated* the activity of CCSP and SP-A , SP-B , [SP-C] , and SP-D promoters as assessed by luciferase reporter assays in HeLa , H441 , and MLE15 cells . Regulation SP3 EPHB2 14597566 1187461 Helicobacter pylori stimulates host vascular endothelial growth factor-A ( vegf-A ) gene expression via *dependent* activation of Sp1 and [Sp3] . Regulation SP3 MAP2K6 14597566 1187467 Helicobacter pylori stimulates host vascular endothelial growth factor-A ( vegf-A ) gene expression via *dependent* activation of Sp1 and [Sp3] . Regulation SP3 SLC9A2 17561809 1785917 Sp1 and [Sp3] *control* constitutive expression of the human promoter by interactions with the proximal promoter and the transcription initiation site . Regulation SPARC CTGF 17133596 1661441 However , the regulatory *role* of on [SPARC] appeared to be negative and very small , while the positive regulatory effects of CTGF on COL1A2 , COL3A1 , COL11A1 , and TIMP3 were less than those of SPARC . Regulation SPARC CTGF 17133596 1661445 In addition , SPARC appears to regulate CTGF in a predominantly positive manner , while may *act* as a negative feedback control on [SPARC] following TGFbeta stimulation . Regulation SPESP1 CA12 1759579 174534 The results suggest that is *involved* in the generation of [ESP] . Regulation SPHK1 CA2 12531188 1048856 *dependent* translocation of [sphingosine kinase] : role in plasma membrane relocation but not activation . Regulation SPHK1 CALM1 23223309 2708052 , the calcium and integrin binding protein ortholog , colocalizes with SPHK-1 at release sites and *regulates* muscarinic mediated synaptic [SPHK-1] recruitment . Regulation SPHK1 CALM3 12531188 1048857 *dependent* translocation of [sphingosine kinase] : role in plasma membrane relocation but not activation . Regulation SPHK1 CALM3 12531188 1048861 These data suggest a *role* for Ca ( 2+ ) in controlling the subcellular distribution but not the activity of [SPHK1a] . Regulation SPHK1 EGF 20938717 2419115 As the EGFR gene is often overexpressed and mutated in GBM , and EGFR has been shown to regulate SphK1 in some cell types , we examined the *effect* of signaling and the constitutively active EGFRvIII mutant on [SphK1] in GBM cells . Regulation SPHK1 EPHB2 23545258 2777740 Given the up-regulated expression of [SphK1] in *response* to the silence of N-ras and other interactions between and SphK1 , it was speculated that combined inhibition of Ras/ERK and SphK1 would create enhanced antitumor effects . Regulation SPHK1 ESR1 20889557 2343274 Various studies in cell lines have previously demonstrated that [sphingosine kinase 1 (SK1)] and extracellular signal regulated kinase 1/2 ( ERK-1/2 ) interact in an *dependent* manner to influence both breast cancer cell growth and migration . Regulation SPHK1 F10 23658376 2810833 The aim of the study was to investigate whether the activated ( FXa ) *regulates* [SPHK1] transcription and the formation of S1P and subsequent mitogenesis and migration of human vascular smooth muscle cells (SMC) . Regulation SPHK1 HRAS 23545258 2777741 Given the up-regulated expression of [SphK1] in *response* to the silence of N-ras and other interactions between and SphK1 , it was speculated that combined inhibition of Ras/ERK and SphK1 would create enhanced antitumor effects . Regulation SPHK1 IGF1 17388800 1720878 The *effect* on [SphK] activity was blocked by specific inhibitors of IGF-IR , PI3K/Akt and ERK1/2 phosphorylation . Regulation SPHK1 IGF2 22016563 2513606 Here , we investigated the mechanism of receptor *dependent* [sphingosine kinase 1 (SK1)] activation in human embryonic kidney 293 cells . Regulation SPHK1 IL10 19074142 2030466 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL11 19074142 2030467 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL13 19074142 2030468 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL15 19074142 2030469 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL16 19074142 2030470 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL18 19074142 2030471 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL19 19074142 2030472 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL1A 19074142 2030488 In summary , our results suggest that [SphK1] expression is transcriptionally *regulated* by in glioblastoma cells , and this pathway may be important in regulating survival and invasiveness of glioblastoma cells . Regulation SPHK1 IL1A 24464131 2913151 In *response* to , cIAP2 and the sphingosine kinase [SphK1] ( the enzyme that generates S1P ) formed a complex with IRF1 , which led to its activation . Regulation SPHK1 IL2 19074142 2030473 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL20 19074142 2030474 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL21 19074142 2030475 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL22 19074142 2030458 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL24 19074142 2030456 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL25 19074142 2030457 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL26 19074142 2030462 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL27 19074142 2030463 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL3 19074142 2030476 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL31 19074142 2030464 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL32 19074142 2030461 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL33 19074142 2030460 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL34 19074142 2030465 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL37 19074142 2030459 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL4 19074142 2030477 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL5 19074142 2030478 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL6 19074142 2030479 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL7 19074142 2030480 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL8 19074142 2030481 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 IL9 19074142 2030482 *regulates* the expression of [sphingosine kinase 1] in glioblastoma cells . Regulation SPHK1 JUN 24342046 2905332 *regulates* [sphingosine kinase 1] expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose . Regulation SPHK1 JUN 24342046 2905334 Given the binding motifs for AP-1 within the first intron of the SphK1 gene , we speculated that the activated in the kidney under HG condition possibly *regulates* [SphK1] expression in a positive feedback manner , thereby promoting the sustained activation of SphK1-S1P pathway and mediating the pathological progression of DN . Regulation SPHK1 JUN 24342046 2905335 Here , we observed the *effect* of on [SphK1] expression in GMCs and explored the molecular mechanism involved in the sustained activation of SphK1-S1P pathway . Regulation SPHK1 KRAS 23545258 2777742 Given the up-regulated expression of [SphK1] in *response* to the silence of N-ras and other interactions between and SphK1 , it was speculated that combined inhibition of Ras/ERK and SphK1 would create enhanced antitumor effects . Regulation SPHK1 MAPK3 17555548 1778568 Furthermore , we demonstrated that and PI3 kinase are *involved* in GDNF induced [SPHK1] transcription by using specific inhibitors . Regulation SPHK1 MAPK3 20804754 2324576 Lysophosphatidic acid stimulates gastric cancer cell proliferation via *dependent* upregulation of [sphingosine kinase 1] transcription . Regulation SPHK1 MAPK3 20804754 2324579 Although LPA activates numerous signaling pathways downstream of its receptors , including extracellular-signal regulated kinase 1/2 , p38 , JNK , and Akt , and the transactivation of the epidermal growth factor receptor , pharmacological and molecular approaches demonstrated that only activation of , in addition to the CCAAT/enhancer binding protein ß transcription factor , is *involved* in transcriptional upregulation of [SphK1] by LPA . Regulation SPHK1 MBTPS1 14592418 1159932 The antiapoptotic *effect* of required activation of [sphingosine kinase] and was accompanied by an increase in MAP-kinase phosphorylation . Regulation SPHK1 MYB 23328083 2758326 c-MYB overexpression and siRNA for c-Myb affected SPHK1 expression , confirming the important regulatory *role* of in [SPHK1] expression . Regulation SPHK1 NRAS 23545258 2777743 Given the up-regulated expression of [SphK1] in *response* to the silence of and other interactions between Ras/ERK and SphK1 , it was speculated that combined inhibition of Ras/ERK and SphK1 would create enhanced antitumor effects . Regulation SPHK1 RHOA 23658376 2810836 These data suggest that FXa induces [SPHK1] expression and increases S1P formation independent of thrombin and that this *involves* the activation of and PKC signalling . Regulation SPI1 IL1B 11823535 909327 We conclude that the IL1B promoter is an IL-1beta-responsive sequence as a result of its ability to bind [Spi-1] in *response* to . Regulation SPN CAPN8 1558970 184585 *Effect* of platelet on normal T-lymphocyte [CD43] : hypothesis of events in the Wiskott-Aldrich syndrome . Regulation SPP1 EPHB2 22588951 2700795 Aldosterone induced [osteopontin] expression in vascular smooth muscle cells *involves* MR , , and p38 MAPK . Regulation SPP1 NT5E 18980528 1983322 We examined how *regulates* the mRNA expression of bone/cementum related proteins ( alkaline phosphatase [ ALPase ] , [osteopontin] [ OPN ] , osteocalcin [ OC ] , and bone morphogenetic protein [ BMP]-2 ) in cultures of HPL cells . Regulation SPP1 NT5E 18980528 1983324 Moreover , the *effects* of on calcification , the production of [OPN] and OC , and DNA synthesis in HPL cells were examined . Regulation SPP1 TLR7 23610145 2804628 Dual *regulation* of [osteopontin] production by stimulation in dendritic cells . Regulation SPP1 TLR7 23610145 2804646 This implies that [OPN] *regulation* by signaling is critical in shaping inflammatory responses and may modulate IL-17 production in response to pathogens . Regulation SPP1 TNF 18353062 1887093 *Effect* of interleukin-2 and on [osteopontin] : molecular function and biological process . Regulation SPP1 TNF 18353062 1887095 A new gene ontology technology was used to predict the molecular function and biological process of the *effect* of IL-2 and on [OPN] . Regulation SPP1 TNF 18353062 1887097 Using GoFigure server , the molecular function and biological process of the *effect* of IL-2 and on [OPN] is predicted . Regulation SPP1 TNF 9610617 508789 On the other hand , IL-1beta , and LPS had little *effect* on [osteopontin] gene expression but fetal calf serum could increase osteopontin mRNA . Regulation SPRED1 EPHB2 15465815 1342234 These data suggest that [Spred-1] negatively *regulates* hematopoiesis by suppressing not only SCF induced but also IL-3 induced activation . Regulation SPRR1B IFNG 20042643 2248048 Here the molecular mechanisms controlling [SPRR1B] gene expression in *response* to IL-1beta and are elucidated . Regulation SPRR1B IFNG 20042643 2248051 Inhibition of p38 abolished the stimulatory *effects* of IL-1beta and on [SPRR1B] , whereas inhibition of JNK and ERK had no effect . Regulation SPRR1B IL1B 20042643 2248049 Here the molecular mechanisms controlling [SPRR1B] gene expression in *response* to and IFN-gamma are elucidated . Regulation SPRR1B IL1B 20042643 2248052 Inhibition of p38 abolished the stimulatory *effects* of and IFN-gamma on [SPRR1B] , whereas inhibition of JNK and ERK had no effect . Regulation SPRR1B MAPK7 12091247 960052 ( ERK5 ) *regulates* squamous differentiation marker [SPRR1B] transcription in Clara-like H441 cells . Regulation SPRR1B MAPK7 12091247 960070 Here , we report for the first time the *involvement* of in PMA-inducible [SPRR1B] transcription in H441 cells . Regulation SPRY2 EPHB2 21762810 2456573 IP3R mediated Ca ( 2+ ) signaling , in turn , was found to influence Spry2 subcellular distribution and , a [Spry2] *regulator* . Regulation SPSB1 TLR7 21876038 2486734 *regulation* of [SPSB1] controls inducible nitric oxide synthase induction . Regulation SQSTM1 EGLN3 23345396 2769821 [p62/SQSTM1] *regulates* cellular oxygen sensing by attenuating activity through aggregate sequestration and enhanced degradation . Regulation SQSTM1 EPHB2 25128814 2957260 can *regulate* cellular levels of LC3B and [SQSTM1/p62] at expression levels . Regulation SQSTM1 MAP2K6 25128814 2957266 can *regulate* cellular levels of LC3B and [SQSTM1/p62] at expression levels . Regulation SRC EPHB2 22766276 2645072 However , U0126 , an inhibitor of , had no significant *effect* on the CsA induced activation of FAK and [Src] . Regulation SRC SLC38A3 12488346 1033000 We found a significant increase in [pp60(c-Src)] kinase activity in *response* to both and PG ( 0.1-1.0 nM ) , suggesting that growth effects of both the precursor and fully processed gastrin molecules may be mediated via similar pathways . Regulation SREBF1 CLU 23515283 2772223 The present study examined whether *regulates* [SREBP-1c] expression and lipid accumulation in the liver . Regulation SREBF1 FAS 19252981 2157094 Transcription of the gene is *controlled* synergistically by the transcription factors ChREBP ( carbohydrate response element binding protein ) , which is induced by glucose , and [SREBP-1] ( sterol response element binding protein-1 ) , which is stimulated by insulin through the PI3K/Akt signal transduction pathway . Regulation SREBF1 FOXO1 22511764 2607880 We examined the *effects* of on [srebp1] gene expression in vivo and in vitro . Regulation SREBF1 FOXO1 24478438 2927951 Further investigation suggested that the expression of [SREBP-1c] and FASN is *controlled* by the transcription factor during HCV infection . Regulation SREBF1 MAP2K6 17681345 1822234 Urokinase plasminogen activator (uPA) stimulates cholesterol biosynthesis in macrophages through activation of [SREBP-1] in a PI3-kinase and *dependent* manner . Regulation SREBF2 EPHB2 16211244 1464538 Collectively , these new findings establish an important role of ERK signaling pathway in SCAP ligand induced transcription of LDLR and imply that the protein synthesis or turnover rate of [SREBP-2] may be *regulated* by . Regulation SRF EPHB2 18498735 1917594 These findings show that [SRF] is a major *effector* of both and MAL signaling by NGF and that SRF is a key mediator of NGF dependent target innervation by embryonic sensory neurons . Regulation SRF MAP2K6 18498735 1917600 These findings show that [SRF] is a major *effector* of both and MAL signaling by NGF and that SRF is a key mediator of NGF dependent target innervation by embryonic sensory neurons . Regulation SRGN HBB 18445056 1951499 FBG and [PPG] have no effect on LV functions , but ( 1C ) levels may *affect* diastolic parameters . Regulation SRGN NEUROD6 18643870 1966851 [Prg1] is *regulated* by the basic helix-loop-helix transcription factor . Regulation SRGN NEUROD6 18643870 1966854 Our results suggest that directly *regulates* [Prg1] expression and that the Math2-Prg1 cascade plays an important role in neurite outgrowth in PC12 cells . Regulation SSB TNF 14872501 1208500 Stratification did not reveal an independent *effect* of and HLA-DRB1*03 on disease or on [anti-SSB] antibody secretion . Regulation SST AGR2 2902147 98911 The acute insulin response ( AIR ) to 2.5 g of arginine during this infusion of epinephrine was significantly higher ( P less than 0.05 ) than in controls as were the ( P less than 0.05 ) and the acute [somatostatin] *response* ( ASLIR ) ( P less than 0.05 ) . Regulation SST TNF 15680393 1370366 The objective of this study was to determine the expression of [somatostatin (SST)] and its receptors ( SSTRs ) and their *regulation* by as well as cell proliferation in response to SST in human endothelial cells . Regulation SST TNF 8978352 408995 The aim of this study was to examine whether IL-8 and could *regulate* [somatostatin] release from isolated canine gastric D cells . Regulation ST14 PLAU 14747469 1226287 Our data identify a novel *role* for [matriptase] for activation of receptor bound . Regulation STAT1 CTGF 17116388 1700607 Inhibitory effects of interferon-gamma on activation of rat pancreatic stellate cells are mediated by [STAT1] and *involve* down-regulation of expression . Regulation STAT1 EPHB2 23825585 2808723 *dependent* activation of [STAT1] mediates dasatinib induced differentiation of acute myeloid leukemia . Regulation STAT1 EPHB2 23825585 2808738 MEK inhibitors PD98059 and U0216 not only inhibited the phosphorylation of STAT1 , but also abrogated dasatinib induced myeloid differentiation , suggesting that *dependent* phosphorylation of [STAT1] might be indispensable for the differentiating effect of dasatinib in AML cells . Regulation STAT1 IL1B 11104703 756491 However , pretreatment with the proteasome inhibitor MG132 under conditions that prevented the IL-1beta dependent activation of the nuclear factor NF-kappaB also blocked the inhibitory *effect* of on IL-6 activated [STAT1] . Regulation STAT1 IL1B 11104703 756496 In related experiments , the protein tyrosine phosphatase inhibitor Na ( 3 ) VO ( 4 ) also antagonized the inhibitory *effect* of on the activation of [STAT1] by IL-6 . Regulation STAT1 IL1B 9916712 587500 IL-1beta did not interfere with IFN-gamma receptor signal transduction , since tyrosine phosphorylation , nuclear translocation , and DNA binding of [STAT-1alpha] to an IFN-gamma activation sequence of the type IV CIITA promoter were not *affected* by . Regulation STAT1 MAP2K6 23825585 2808729 *dependent* activation of [STAT1] mediates dasatinib induced differentiation of acute myeloid leukemia . Regulation STAT1 MAP2K6 23825585 2808744 MEK inhibitors PD98059 and U0216 not only inhibited the phosphorylation of STAT1 , but also abrogated dasatinib induced myeloid differentiation , suggesting that *dependent* phosphorylation of [STAT1] might be indispensable for the differentiating effect of dasatinib in AML cells . Regulation STAT1 PLAU 9417082 480404 Using an electrophoretic mobility shift assay , we then demonstrated that [Stat1] is rapidly activated in *response* to stimulation with and specifically binds to the DNA regulatory elements GAS ( interferon-gamma activation site ) and ISRE ( interferon stimulated response element ) . Regulation STAT1 PLAU 9974409 596529 Using electrophoretic mobility shift and supershift assays , we then demonstrated that [Stat1] is rapidly activated in endothelial cells in *response* to and ATF . Regulation STAT1 RARB 10597280 573592 The direct *involvement* of in atRA induced [STAT1] gene activation was further demonstrated by showing that transfection with an anti-sense RAR beta construct blocked atRA induced STAT1 expression in MCF-7 cells whereas introduction of a sense-RAR beta construct resulted in STAT1 induction by atRA in MDA-MB 231 cells . Regulation STAT1 STAT4 19661066 2143757 Berberine down-regulated the activity of [STAT1] and STAT4 through the suppression of p38 MAPK and JNK activation , and it *controlled* the stability of through the ubiquitin-proteasome pathway . Regulation STAT1 TNF 10825233 696426 did not *affect* [STAT1] activation , but stimulated DNA binding and transcriptional activity of NF-kappaB , both of which were further increased by IFN-gamma . Regulation STAT1 TNF 16648019 1553305 Results from both the electrophoretic mobility shift assay- and the ELISA based assays verified [STAT1] and STAT3 *responses* to and PYY . Regulation STAT2 PLAU 10446176 636371 In this study , we demonstrate that Stat4 and [Stat2] , but not Stat3 , Stat5 , or Stat6 , are rapidly activated in *response* to . Regulation STAT3 CCND1 11279133 811826 Whereas had no *effect* on the steady-state level of [STAT3] proteins in the cytoplasm , it was found to reduce the STAT3 nuclear level in HepG2 cells . Regulation STAT3 CHI3L1 21953450 2507266 Furthermore , is a migration factor for primary astrocytes , and its expression is *controlled* by both NFI-X3 and [STAT3] , which are known regulators of gliogenesis . Regulation STAT3 EPHB2 11780390 891066 To investigate the regulation *effect* of protein kinase on the activation of transcription factor [STAT3] in response to IL-6 in the Sko-007 human myeloma cell line . Regulation STAT3 EPHB2 12555068 1051603 Western blot analysis and electrophoretic mobility shift assay showed that DIF-1 inhibited [STAT3] activity in an *dependent* manner in gastric cancer cell lines , AGS and MKN28 . Regulation STAT3 EPHB2 19885032 2161014 Serine phosphorylated STAT3 by IL-6 was transported into Schwann cell nuclei , thereby indicating that may *regulate* the transcriptional activity of [STAT3] via the induction of serine phosphorylation of STAT3 . Regulation STAT3 FOXO1 12456685 1055062 The *effect* of required the presence of functional STAT3 and was abrogated by the expression of dominant negative [STAT3] mutants . Regulation STAT3 IL1B 11071643 748134 Exposing primary rat hepatocytes to had no *effect* on IL-6 mediated [STAT3] activation ; Regulation STAT3 IL1B 11382751 834998 Either inhibitor alone prevented STAT3 phosphorylation , implicating ERKs and p38 ( MAPK ) in the delayed [STAT3] *response* to . Regulation STAT3 IL1B 14664905 1177724 In the same cell type neither *dependent* SAPK activation nor IL-6 induced [STAT3] phosphorylation is affected by the drug . Regulation STAT3 IL1B 17663801 1780458 In *response* to , or IL10 , the levels of phosphorylated NF-kappaB and [STAT3] -- respectively -- increased significantly for all the studied cell types . Regulation STAT3 IL1B 19666510 2125976 Similarly , Th17 cells produce IL-17A in *response* to and a [STAT3] activator and Th1 cells produce IFNgamma in response to IL-18 and a STAT4 inducer . Regulation STAT3 IL6R 16432158 1516169 Epigenetic modification of SOCS-1 differentially regulates [STAT3] activation in *response* to and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas . Regulation STAT3 MAP2K6 12555068 1051609 Western blot analysis and electrophoretic mobility shift assay showed that DIF-1 inhibited [STAT3] activity in an *dependent* manner in gastric cancer cell lines , AGS and MKN28 . Regulation STAT3 MAP2K6 23624919 2926215 inhibition *affects* [STAT3] signaling and invasion in human melanoma cell lines . Regulation STAT3 PLAU 10446176 636372 In this study , we demonstrate that Stat4 and Stat2 , but not [Stat3] , Stat5 , or Stat6 , are rapidly activated in *response* to . Regulation STAT3 RGS2 23238822 2769155 knock-down elevated Pam3 CSK4 induced STAT3 phosphorylation , but RGS2 overexpression had the opposite *effect* on [STAT3] phosphorylation . Regulation STAT3 TNF 11416024 829227 Immunoblot analysis of hypothalamic lysates with a phospho-specific STAT3 antibody showed a 6- to 7-fold stimulation of [STAT3] tyrosine phosphorylation in *response* to both leptin and . Regulation STAT3 TNF 16648019 1553306 Results from both the electrophoretic mobility shift assay- and the ELISA based assays verified STAT1 and [STAT3] *responses* to and PYY . Regulation STAT4 IFNB1 17351016 1741146 Reciprocal *effects* of and IL-12 on [STAT4] activation and cytokine induction in T cells . Regulation STAT4 IFNG 11466347 839909 An absolute requirement for [STAT4] and a *role* for as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex . Regulation STAT4 IFNG 12242445 989977 Critical role for [STAT4] activation by type 1 interferons in the *response* to viral infection . Regulation STAT4 IFNG 18988675 2034961 The activation of STAT4beta was mediated by IL-12 and not IFNgamma because deliberate addition or neutralization of IL-12 , but not , *affected* the activation of [STAT4beta] . Regulation STAT4 IL10 8700208 372979 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL11 8700208 372980 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL12A 10491012 645888 Th2 T cells express only the IL-12R beta 1 and thus do not tyrosine phosphorylate [STAT4] in *response* to . Regulation STAT4 IL12A 10779770 687498 Monocyte expressed [Stat4] in humans is phosphorylated in *response* to IFN-alpha , but not . Regulation STAT4 IL12A 10820390 694504 selectively *regulates* [STAT4] via phosphatidylinositol 3-kinase and Ras independent signal transduction pathways . Regulation STAT4 IL12A 10820390 694523 This reveals that the STAT1 , 3 and 4 serine kinases are not coordinately regulated in human T cells and that must *regulate* serine phosphorylation of [STAT4] by a kinase network distinct to the MAPK Erk1 ,2 or PI3K pathways . Regulation STAT4 IL12A 10961885 726597 Although the site surrounding serine 721 is an optimum consensus sequence for mitogen activated family of protein kinases ( MAPKs ) -mediated phosphorylation , we demonstrate that does not induce extracellular signal regulated kinase ( ERK ) or c-Jun N-terminal kinase (JNK) activation in T and natural killer ( NK ) cells and that IL-12 induced [STAT4] transcriptional activity is not *affected* by these kinases . Regulation STAT4 IL12A 11120802 758223 [Stat4] is activated in *response* to . Regulation STAT4 IL12A 12147631 970079 Moreover , *dependent* transcriptional up-regulation of T-bet and [STAT4] was deficient in the HSA ( + ) CD4 SP thymocytes . Regulation STAT4 IL12A 15004198 1217421 Using EMSA , confocal laser microscopy , and Western blotting , we demonstrated that the nuclear translocation of [STAT4] in *response* to is reduced in PHA activated T cells from the patient when compared with those from healthy subjects . Regulation STAT4 IL12A 16081070 1442789 [STAT4] is a transcription factor activated in *response* to , and is involved in Th1 cell development . Regulation STAT4 IL12A 17351016 1741147 Reciprocal *effects* of IFN-beta and on [STAT4] activation and cytokine induction in T cells . Regulation STAT4 IL12A 23064011 2689957 Investigation into the signaling mechanism suggested that phosphorylation of [STAT-4] in *response* to was sustained for a longer duration in aged CD4+ T cells as compared to CD4+ T cells from young subjects . Regulation STAT4 IL12B 10491012 645889 Th2 T cells express only the IL-12R beta 1 and thus do not tyrosine phosphorylate [STAT4] in *response* to . Regulation STAT4 IL12B 10779770 687499 Monocyte expressed [Stat4] in humans is phosphorylated in *response* to IFN-alpha , but not . Regulation STAT4 IL12B 10820390 694505 selectively *regulates* [STAT4] via phosphatidylinositol 3-kinase and Ras independent signal transduction pathways . Regulation STAT4 IL12B 10820390 694524 This reveals that the STAT1 , 3 and 4 serine kinases are not coordinately regulated in human T cells and that must *regulate* serine phosphorylation of [STAT4] by a kinase network distinct to the MAPK Erk1 ,2 or PI3K pathways . Regulation STAT4 IL12B 10961885 726598 Although the site surrounding serine 721 is an optimum consensus sequence for mitogen activated family of protein kinases ( MAPKs ) -mediated phosphorylation , we demonstrate that does not induce extracellular signal regulated kinase ( ERK ) or c-Jun N-terminal kinase (JNK) activation in T and natural killer ( NK ) cells and that IL-12 induced [STAT4] transcriptional activity is not *affected* by these kinases . Regulation STAT4 IL12B 11120802 758224 [Stat4] is activated in *response* to . Regulation STAT4 IL12B 12147631 970080 Moreover , *dependent* transcriptional up-regulation of T-bet and [STAT4] was deficient in the HSA ( + ) CD4 SP thymocytes . Regulation STAT4 IL12B 15004198 1217422 Using EMSA , confocal laser microscopy , and Western blotting , we demonstrated that the nuclear translocation of [STAT4] in *response* to is reduced in PHA activated T cells from the patient when compared with those from healthy subjects . Regulation STAT4 IL12B 16081070 1442790 [STAT4] is a transcription factor activated in *response* to , and is involved in Th1 cell development . Regulation STAT4 IL12B 17351016 1741148 Reciprocal *effects* of IFN-beta and on [STAT4] activation and cytokine induction in T cells . Regulation STAT4 IL12B 23064011 2689958 Investigation into the signaling mechanism suggested that phosphorylation of [STAT-4] in *response* to was sustained for a longer duration in aged CD4+ T cells as compared to CD4+ T cells from young subjects . Regulation STAT4 IL13 8700208 372981 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL15 8700208 372982 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL16 8700208 372983 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL18 8700208 372984 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL19 8700208 372985 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL2 8700208 372986 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL2 9886399 584686 This activation of [STAT4] in *response* to is not due to the autocrine production of IL-12 or IFN-alpha . Regulation STAT4 IL2 9886399 584690 Although the activation of [STAT4] in *response* to occurs in primary resting and activated NK cells , it does not occur in primary resting T cells or mitogen activated T cells . Regulation STAT4 IL20 8700208 372987 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL21 8700208 372988 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL22 8700208 372971 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL24 8700208 372969 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL25 8700208 372970 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL26 8700208 372975 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL27 8700208 372976 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL3 8700208 372989 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL31 8700208 372977 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL32 8700208 372974 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL33 8700208 372973 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL34 8700208 372978 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL37 8700208 372972 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL4 8700208 372990 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL5 8700208 372991 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL6 8700208 372992 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL7 8700208 372993 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL8 8700208 372994 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 IL9 8700208 372995 Requirement for [Stat4] in mediated *responses* of natural killer and T cells . Regulation STAT4 MAPK1 10820390 694516 The object of the present study was to explore the *role* of mitogen activated protein kinases (MAPK) Erk1 and and phosphatidylinositol 3-kinase (PI3K) in [STAT4] regulation . Regulation STAT4 MAPK3 10820390 694517 The object of the present study was to explore the *role* of mitogen activated protein kinases (MAPK) and Erk2 and phosphatidylinositol 3-kinase (PI3K) in [STAT4] regulation . Regulation STAT4 PI3 10820390 694518 The object of the present study was to explore the *role* of mitogen activated protein kinases (MAPK) Erk1 and Erk2 and in [STAT4] regulation . Regulation STAT4 PLAU 10446176 636373 In this study , we demonstrate that [Stat4] and Stat2 , but not Stat3 , Stat5 , or Stat6 , are rapidly activated in *response* to . Regulation STAT4 S100A4 22740693 2659660 Collectively , we conclude that HBXIP up-regulates S100A4 through activating promoter *involving* [STAT4] and inducing PTEN/PI3K/AKT signaling to promote growth and migration of breast cancer cells . Regulation STAT4 SOCS3 14559241 1153816 These results suggest that , expressed at high levels in Th2 cells , *plays* an inhibitory role in [STAT4] mediated IL-12 signaling by binding to the STAT4 docking site in IL-12Rbeta2 , thus raising a possibility that SOCS-3 may play a role in regulation of Th differentiation . Regulation STAT4 STAT1 19661066 2143758 Berberine down-regulated the activity of and STAT4 through the suppression of p38 MAPK and JNK activation , and it *controlled* the stability of [STAT4] through the ubiquitin-proteasome pathway . Regulation STAT4 STAT4 19661066 2143759 Berberine down-regulated the activity of STAT1 and [STAT4] through the suppression of p38 MAPK and JNK activation , and it *controlled* the stability of through the ubiquitin-proteasome pathway . Regulation STAT5A PLAU 10446176 636374 In this study , we demonstrate that Stat4 and Stat2 , but not Stat3 , [Stat5] , or Stat6 , are rapidly activated in *response* to . Regulation STAT5B MAP2K6 10350046 617004 However , inhibition of had no *effect* on the phosphorylation level of [Stat5b] or on the nuclear translocation of Stat5b . Regulation STAT6 CAPN8 18945965 2028748 Our data suggest that , an oxidative stress induced cysteine protease , is *involved* in the PRELI induced down-regulation of [STAT6] . Regulation STAT6 CAPN8 21276008 2431198 PARP-1 deficiency blocks IL-5 expression through *dependent* degradation of [STAT-6] in a murine asthma model . Regulation STAT6 CD14 24866794 2945614 Finally , we demonstrated that *regulates* [STAT6] activation , as Cd14 ( -/- ) mice had increased STAT6 activation in vivo , suggesting that lack of CD14 impacts the IL-4Ra-STAT6 pathway , altering macrophage polarization during parasite infection . Regulation STAT6 EPHB2 21764283 2591559 In search of the upstream target of ?TE by using inhibitor and siRNA approaches , we discovered that the atypical protein kinase C ( aPKC ) signaling , instead of classical PKC , p38 MAPK , JNK or , *played* a critical role in IL-13 stimulated eotaxin generation and [STAT6] activation . Regulation STAT6 PLAU 10446176 636375 In this study , we demonstrate that Stat4 and Stat2 , but not Stat3 , Stat5 , or [Stat6] , are rapidly activated in *response* to . Regulation STAT6 TNF 16004996 1431190 Overall our results suggest that IL-4 regulates induced IL-8 expression at a transcriptional level and this mechanism *involves* [STAT6] and NF-kappaB transcription factors . Regulation STEAP4 TNF 18430367 1900138 Finally , we confirmed that cultured human omental adipose tissue undergoes mediated *regulation* of the [STEAP4] expression . Regulation STIM1 CAPN8 21876174 2478030 [STIM1] *involves* the activation of Ca ( 2+ ) -regulated protease , as well as Ca ( 2+ ) -regulated cytoplasmic kinase Pyk2 , which regulate the focal-adhesion dynamics of migratory cervical cancer cells . Regulation STK39 BRSK2 23907667 2861545 ( also known as SAD-A ) , a [serine/threonine kinase] of the AMP activated protein kinase family *affected* VCP/p97 activity in ERAD . Regulation STK39 CA2 10677501 668151 Death associated protein kinase ( DAP-kinase ) is a *regulated* [serine/threonine kinase] with a multidomain structure that participates in apoptosis induced by a variety of signals . Regulation STK39 CA2 15010850 1217991 Death associated protein kinase (DAPK) is a *dependent* [serine/threonine kinase] that has been implicated as a positive mediator of apoptosis . Regulation STK39 CA2 15151256 1249930 Death associated protein kinase ( DAP kinase ) is a *dependent* [serine/threonine kinase] implicated as a positive apoptosis mediator . Regulation STK39 CA2 15583830 1356012 Death associated protein kinase (DAPK) is a *dependent* [serine/threonine kinase] that is thought to mediate apoptosis . Regulation STK39 CA2 16596273 1544869 Death associated protein kinase (DAPK) is a *dependent* [serine/threonine kinase] that is thought to mediate apoptosis . Regulation STK39 CA2 19287947 2046682 Although death associated protein kinase (DAPK) is a *regulated* [serine/threonine kinase] that plays important roles in various types of apoptotic cell death , there have been no reports of its tissue distributions and functions in female reproductive organs . Regulation STK39 CA2 22868392 2671614 Death associated protein kinase (DAPK) is a *regulated* [serine/threonine kinase] that mediates cell death . Regulation STK39 CALM3 10561695 566889 Death associated protein kinase ( DAP-kinase ) is Ca ( 2+ ) *dependent* [serine/threonine kinase] that contains ankyrin repeats and the death domain . Regulation STK39 CALM3 10629061 659374 DRP-1 is a 42-kDa Ca ( 2+ ) *regulated* [serine threonine kinase] which shows high degree of homology to DAP kinase . Regulation STK39 CALM3 10677501 668152 Death associated protein kinase ( DAP-kinase ) is a *regulated* [serine/threonine kinase] with a multidomain structure that participates in apoptosis induced by a variety of signals . Regulation STK39 CALM3 11313698 805531 DAP-kinase is a pro-apoptotic Ca ( 2+ ) *regulated* [serine/threonine kinase] that participates in a wide array of apoptotic systems initiated by interferon-gamma , TNF-alpha , activated Fas , and detachment from extracellular matrix . Regulation STK39 CALM3 11313923 805882 Death associated protein (DAP)-kinase is a 16 kDa *dependent* [serine/threonine kinase] that carries a death domain at its C-terminus . Regulation STK39 CALM3 11997670 939513 Death associated protein kinase ( DAP-kinase ) is a pro-apoptotic *regulated* [serine/threonine kinase] with a multidomain structure that participates in a wide array of apoptotic systems initiated by IFN-gamma , TNF-alpha , activated Fas , and detachment from extracellular matrix . Regulation STK39 CALM3 12370243 995625 Death associated protein kinase ( DAP-kinase ) is a *dependent* [serine/threonine kinase] , and participates in various apoptosis systems . Regulation STK39 CALM3 15010850 1217992 Death associated protein kinase (DAPK) is a *dependent* [serine/threonine kinase] that has been implicated as a positive mediator of apoptosis . Regulation STK39 CALM3 15151256 1249931 Death associated protein kinase ( DAP kinase ) is a *dependent* [serine/threonine kinase] implicated as a positive apoptosis mediator . Regulation STK39 CALM3 15213270 1262559 Death associated protein kinase (DAPK) is a *dependent* [serine/threonine kinase] localized to renal tubular epithelial cells . Regulation STK39 CALM3 15583830 1356013 Death associated protein kinase (DAPK) is a *dependent* [serine/threonine kinase] that is thought to mediate apoptosis . Regulation STK39 CALM3 16448786 1528015 Myosin light chain kinase 2 , skeletal muscle ( MYLK2 ) encodes a *dependent* [serine/threonine kinase] . Regulation STK39 CALM3 16596273 1544870 Death associated protein kinase (DAPK) is a *dependent* [serine/threonine kinase] that is thought to mediate apoptosis . Regulation STK39 CALM3 19287947 2046683 Although death associated protein kinase (DAPK) is a *regulated* [serine/threonine kinase] that plays important roles in various types of apoptotic cell death , there have been no reports of its tissue distributions and functions in female reproductive organs . Regulation STK39 CALM3 20479242 2269567 We have identified a mechanism for FFR involving heart rate dependent phosphorylation of the major cardiac sarcoplasmic reticulum calcium release channel/ryanodine receptor ( RyR2 ) , at Ser2814 , by *dependent* [serine/threonine kinase-delta] ( CaMKIIdelta ) . Regulation STK39 CALM3 22868392 2671615 Death associated protein kinase (DAPK) is a *regulated* [serine/threonine kinase] that mediates cell death . Regulation STK39 CALM3 23062356 2785984 These findings also uncover eukaryotic elongation factor 2 kinase ( eEF2K ) , a *dependent* [serine/threonine kinase] that phosphorylates eEF2 and regulates the elongation step of protein translation , as a major molecular substrate mediating the rapid antidepressant effect of ketamine . Regulation STK39 CALM3 23173822 2729809 Levels of multiple glutamate receptor subunits , *dependent* protein kinase II ( CaMKII ) , a highly abundant [serine/threonine kinase] , and spinophilin , a F-actin and protein phosphatase 1 (PP1) binding protein , were significantly lower in striatal extracts , as well as in synaptic and/or extrasynaptic fractions , compared with similar hippocampal extracts/fractions . Regulation STK39 CALM3 8626500 360383 Dual *regulation* of a chimeric plant [serine/threonine kinase] by calcium and . Regulation STK39 CAV1 9374534 465240 binding negatively *regulates* tyrosine and [serine/threonine kinase] activities . Regulation STK39 CAV2 9374534 465241 binding negatively *regulates* tyrosine and [serine/threonine kinase] activities . Regulation STK39 CAV3 9374534 465242 binding negatively *regulates* tyrosine and [serine/threonine kinase] activities . Regulation STK39 CDK5 24872548 2940893 Although the kinase activity of Mst3 is essential for its functions in neuronal morphogenesis and migration , it is *regulated* via its phosphorylation at Ser79 by a [serine/threonine kinase] , . Regulation STK39 CSK 10951585 723839 Such co-expression is consistent with a *role* for Hydra in regulation of [STK] activity . Regulation STK39 GSK3B 19384566 2069198 ( GSK3beta ) , a multifunctional [serine/threonine kinase] negatively *regulated* neurite outgrowth of N2a cells ; Regulation STK39 HRAS 14719068 1197677 BRAF encodes a *regulated* [serine/threonine kinase] that mediates the pathway for cell growth and malignant transformation . Regulation STK39 HRAS 14961576 1208646 All tumors and cell lines were additionally analyzed for mutation and expression of BRAF , which encodes a *regulated* [serine/threonine kinase] with oncogenic properties , as well as for expression of RASSF1A , which encodes a Ras binding protein with tumor suppressor properties . Regulation STK39 HRAS 15517309 1335607 All tumors were additionally analyzed for mutations in BRAF , which encodes a *regulated* [serine/threonine kinase] with oncogenic properties . Regulation STK39 HSP90AA1 15935620 1452002 Akt ( PKB ) is an *dependent* [serine-threonine kinase] that plays critical roles in the regulation of muscle cell physiology , including roles in the regulation of muscle differentiation and anti-apoptotic responses that modulate cell survival . Regulation STK39 HYAL2 15363108 1304057 Due to difficulty with reproducibility of the transformation assay in BEAS-2B cells , we have used more tractable rodent fibroblast models to further study modulation of RON/Stk transforming activity and potential *effects* of Hyal2 on [RON/Stk] activation by its natural ligand , macrophage stimulating protein (MSP) . Regulation STK39 INS 1902232 156033 We have examined the phosphorylation of the [serine threonine kinase] , the product of c-raf proto-oncogene in *response* to or platelet derived growth factor in intact cells . Regulation STK39 KRAS 14719068 1197678 BRAF encodes a *regulated* [serine/threonine kinase] that mediates the pathway for cell growth and malignant transformation . Regulation STK39 KRAS 14961576 1208647 All tumors and cell lines were additionally analyzed for mutation and expression of BRAF , which encodes a *regulated* [serine/threonine kinase] with oncogenic properties , as well as for expression of RASSF1A , which encodes a Ras binding protein with tumor suppressor properties . Regulation STK39 KRAS 15517309 1335608 All tumors were additionally analyzed for mutations in BRAF , which encodes a *regulated* [serine/threonine kinase] with oncogenic properties . Regulation STK39 MST1R 15363108 1304058 Due to difficulty with reproducibility of the transformation assay in BEAS-2B cells , we have used more tractable rodent fibroblast models to further study Hyal2 modulation of transforming activity and potential *effects* of Hyal2 on [RON/Stk] activation by its natural ligand , macrophage stimulating protein (MSP) . Regulation STK39 NRAS 14719068 1197679 BRAF encodes a *regulated* [serine/threonine kinase] that mediates the pathway for cell growth and malignant transformation . Regulation STK39 NRAS 14961576 1208648 All tumors and cell lines were additionally analyzed for mutation and expression of BRAF , which encodes a *regulated* [serine/threonine kinase] with oncogenic properties , as well as for expression of RASSF1A , which encodes a Ras binding protein with tumor suppressor properties . Regulation STK39 NRAS 15517309 1335609 All tumors were additionally analyzed for mutations in BRAF , which encodes a *regulated* [serine/threonine kinase] with oncogenic properties . Regulation STK39 PAK1 23038262 2698519 Based on these findings , we further investigated in this study the transcriptional *regulation* of TF and TFPI by , a [serine/threonine kinase] . Regulation STK39 PCNA 8637234 358134 p16(INK4A) and p18 proteins are highly specific inhibitors of *dependent* [serine/threonine kinase] activities required for the overcoming of the G1 checkpoint in the eukaryotic cell division cycle . Regulation STK39 PI3 11278835 802853 Akt , also known as protein kinase B , is a [protein-serine/threonine kinase] that is activated by growth factors in a *dependent* manner . Regulation STK39 PI3 12084724 976423 BMP-2 stimulated Akt [serine/threonine kinase] activity in a *dependent* manner in osteoblast precursor cells . Regulation STK39 PIK3CA 17000121 1633875 *dependent* activation of the [serine-threonine kinase] , Akt , suppressed CSR , in part , through the inactivation of the Forkhead Box family ( Foxo ) of transcription factors . Regulation STK39 PIK3CA 24043625 2862702 Serum and glucocorticoid regulated kinase 1 ( SGK1 ) encodes a *dependent* [serine/threonine kinase] that is rapidly induced in response to cellular stressors and is an important cell survival signal . Regulation STK39 PIK3R1 17000121 1633876 *dependent* activation of the [serine-threonine kinase] , Akt , suppressed CSR , in part , through the inactivation of the Forkhead Box family ( Foxo ) of transcription factors . Regulation STK39 PIK3R1 24043625 2862703 Serum and glucocorticoid regulated kinase 1 ( SGK1 ) encodes a *dependent* [serine/threonine kinase] that is rapidly induced in response to cellular stressors and is an important cell survival signal . Regulation STK39 PRKDC 23386830 2739672 Non-homologous end joining a major mechanism for the repair of double-strand breaks ( DSB ) in DNA is *regulated* in part by the [serine/threonine kinase] , . Regulation STK39 RHO 15659308 1364869 Vasoconstrictor factors , like urotensin , angiotensin and catecholamines , activate *dependent* [serine-threonine kinase] ( Rho-kinase ) and inhibition of this pathway represents a novel therapy for cardiovascular diseases with hypertensive syndrome . Regulation STK39 RHOA 21671918 2442873 In somatic cells , *regulates* a [serine/threonine kinase] known as Rho-kinase ( ROCK ) . Regulation STK39 ROCK1 21671918 2442871 In somatic cells , RhoA *regulates* a [serine/threonine kinase] known as Rho-kinase ( ) . Regulation STK39 ROCK2 21671918 2442872 In somatic cells , RhoA *regulates* a [serine/threonine kinase] known as Rho-kinase ( ) . Regulation STK39 XRCC5 23386830 2739670 Non-homologous end joining a major mechanism for the repair of double-strand breaks ( DSB ) in DNA is *regulated* in part by the [serine/threonine kinase] , . Regulation STK39 XRCC6 23386830 2739671 Non-homologous end joining a major mechanism for the repair of double-strand breaks ( DSB ) in DNA is *regulated* in part by the [serine/threonine kinase] , . Regulation STK4 FAS 19062280 2001795 NDR kinase is activated by [RASSF1A/MST1] in *response* to receptor stimulation and promotes apoptosis . Regulation STK4 FOXO1 19221179 2061638 We also find a requirement for MST1 in cell death of granule neurons upon withdrawal of growth factors and neuronal activity , and [MST1] induces cell death in a *dependent* manner . Regulation STK4 TNF 23085515 2713720 The *effect* of on [MST1] activation was reversed by the reducing agent N-acetyl-l-cysteine . Regulation STMN1 EPHB2 19241002 2040551 We demonstrate the utility of this approach by studying the *dependent* changes in [stathmin] phosphorylation induced by NGF in primary sympathetic neurons . Regulation STMN1 MAP2K6 19241002 2040557 We demonstrate the utility of this approach by studying the *dependent* changes in [stathmin] phosphorylation induced by NGF in primary sympathetic neurons . Regulation STMN2 CAPN8 16822511 1612819 Taxol and tau overexpression induced *dependent* degradation of the microtubule destabilizing [protein SCG10] . Regulation STMN2 CAPN8 16822511 1612860 Collectively , these results indicate that tau overexpression and Taxol treatment induced a *dependent* degradation of the microtubule destabilizing [protein SCG10] . Regulation STS IL1B 11996939 939191 Regulation of estrogen activity in human endometrium : *effect* of on [steroid sulfatase] activity in human endometrial stromal cells . Regulation STS IL1B 11996939 939192 We investigated the *effect* of on [steroid sulfatase] ( STS ) activity and the expression of STS mRNA in human endometrial stromal cells . Regulation STS IL1B 11996939 939193 The present study is the first to demonstrate *regulation* of [STS] activity locally in human endometrium . Regulation STS IL1B 11996939 939194 This initial demonstration of *regulation* of [STS] implies that IL-1beta may control the steroid microenvironment in human uterine endometrium by reducing biologic action of estrogen . Regulation STS TNF 11282280 764737 The cytokine or the STS inhibitor , 2-methoxyoestrone-3-O-sulphamate , had no *effect* on [STS] mRNA expression in fibroblasts . Regulation STS TNF 21904110 2511212 To investigate whether tumor necrosis factor (TNF)-a is able to regulate gene transcription of STS , we studied the *effect* of on [STS] expression in PC-3 human prostate cancer cells . Regulation SUMO1 EPHB2 16713578 1564964 While PIASxalpha functions as a coactivator to facilitate [SUMO] and HDAC-2 removal from Elk-1 in *response* to pathway activation , PIASxalpha acts in the opposite manner to inhibit HDAC-2 and SUMO loss following stress activated MAP kinase pathway signaling . Regulation SUMO1 EPHB2 17284251 1718405 is *involved* in [SUMO-1] foci formation on apoptosis . Regulation SUMO1 MAP2K6 17284251 1718411 is *involved* in [SUMO-1] foci formation on apoptosis . Regulation SUMO2 EPHB2 16713578 1564963 While PIASxalpha functions as a coactivator to facilitate [SUMO] and HDAC-2 removal from Elk-1 in *response* to pathway activation , PIASxalpha acts in the opposite manner to inhibit HDAC-2 and SUMO loss following stress activated MAP kinase pathway signaling . Regulation SUMO2 MMP28 23417988 2843380 Collectively , we show that despite their high homology , [SUMO-2/3] are differentially regulated by TNF-a and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation SUMO2 MMP7 23417988 2843395 Collectively , we show that despite their high homology , [SUMO-2/3] are differentially regulated by TNF-a and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation SUMO2 TNF 23417988 2843375 Collectively , we show that despite their high homology , [SUMO-2/3] are differentially regulated by TNF-a and selectively *control* mediated MMP expression via the NF-?B pathway . Regulation SUMO3 EPHB2 16713578 1564962 While PIASxalpha functions as a coactivator to facilitate [SUMO] and HDAC-2 removal from Elk-1 in *response* to pathway activation , PIASxalpha acts in the opposite manner to inhibit HDAC-2 and SUMO loss following stress activated MAP kinase pathway signaling . Regulation SUMO3 MMP28 23417988 2843357 Collectively , we show that despite their high homology , [SUMO-2/3] are differentially regulated by TNF-a and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation SUMO3 MMP7 23417988 2843372 Collectively , we show that despite their high homology , [SUMO-2/3] are differentially regulated by TNF-a and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation SUMO3 TNF 23417988 2843352 Collectively , we show that despite their high homology , [SUMO-2/3] are differentially *regulated* by and selectively control TNF-a mediated MMP expression via the NF-?B pathway . Regulation SUMO4 EPHB2 16713578 1564965 While PIASxalpha functions as a coactivator to facilitate [SUMO] and HDAC-2 removal from Elk-1 in *response* to pathway activation , PIASxalpha acts in the opposite manner to inhibit HDAC-2 and SUMO loss following stress activated MAP kinase pathway signaling . Regulation SYF2 CAPN8 11784720 916735 The Ca ( 2+ ) ionophore ionomycin and the excitotoxin glutamate induced production of [p29] in cultures of cortical neurons in a *dependent* manner . Regulation SYK EPHB2 10415002 631131 These results suggest a positive feedback *regulation* of [Syk] by in the cascade coupling the type 1 Fc epsilon receptor to the secretory response of mast cells ; Regulation SYK IL1B 19339971 2080760 Here we demonstrate that the tyrosine kinase [Syk] , operating downstream of several immunoreceptor tyrosine based activation motif ( ITAM ) -coupled fungal pattern recognition receptors , *controls* both synthesis and inflammasome activation after cell stimulation with Candida albicans . Regulation SYK IL1B 20401456 2282156 Recent work has uncovered essential *roles* for the [spleen tyrosine kinase (SYK)] and the cytosolic NLRP3 inflammasome for production in innate antifungal immunity . Regulation SYK TNF 15240695 1270341 Immunoprecipitation of cells with Syk Abs showed *dependent* association of [Syk] with both TNFR1 and TNFR2 ; Regulation SYN1 EPHB2 16237176 1470806 Consistent with a presynaptic function for endogenous H-ras/extracellular signal regulated kinase ( ERK ) signaling , we observed that , under normal physiologic conditions in wild-type mice , hippocampus dependent learning stimulated the *dependent* phosphorylation of [synapsin I] , and MEK ( MAP kinase kinase ) /ERK inhibition selectively decreased the frequency of miniature EPSCs . Regulation SYN1 EPHB2 16237176 1470808 By generating transgenic mice expressing a constitutively active form of H-ras ( H-rasG12V ) , which is abundantly localized in axon terminals , we were able to increase the *dependent* phosphorylation of [synapsin I] . Regulation SYN1 EPHB2 20159961 2214852 However , the physiological role of *dependent* [synapsin] phosphorylation in regulating synaptic formation and function is poorly understood . Regulation SYN1 EPHB2 20159961 2214936 Our findings show that *dependent* [synapsin] phosphorylation has a dual role both in the establishment of functional synaptic connections and their short-term plasticity , indicating that some of the multiple extranuclear functions of MAPK/Erk in neurons can be mediated by the same multifunctional presynaptic target . Regulation SYN2 EPHB2 20159961 2214866 However , the physiological role of *dependent* [synapsin] phosphorylation in regulating synaptic formation and function is poorly understood . Regulation SYN2 EPHB2 20159961 2214950 Our findings show that *dependent* [synapsin] phosphorylation has a dual role both in the establishment of functional synaptic connections and their short-term plasticity , indicating that some of the multiple extranuclear functions of MAPK/Erk in neurons can be mediated by the same multifunctional presynaptic target . Regulation SYN3 EPHB2 20159961 2214880 However , the physiological role of *dependent* [synapsin] phosphorylation in regulating synaptic formation and function is poorly understood . Regulation SYN3 EPHB2 20159961 2214964 Our findings show that *dependent* [synapsin] phosphorylation has a dual role both in the establishment of functional synaptic connections and their short-term plasticity , indicating that some of the multiple extranuclear functions of MAPK/Erk in neurons can be mediated by the same multifunctional presynaptic target . Regulation SYNCRIP IL1B 19454352 2084487 The known fungal pattern recognition receptors TLR2 and Dectin-1 regulate IL-1beta gene transcription , whereas the NLRP3 containing proinflammatory [multiprotein complex] , the NLRP3 inflammasome , *controls* caspase-1 mediated cleavage of . Regulation SYNM ELAVL2 24189465 2864301 Based on the acquired data , we propose a theoretical model of imbalanced SN functioning in narcissism in which the dysfunctional AI is *responsible* for constant [DMN] activation , which , in turn , centers one 's attention on the self . Regulation SYNM MBD2 6413080 30572 The results are discussed in terms of what is known about the *role* of in the metabolic activation of [DMN] in other systems . Regulation SYT1 TNF 15637292 1381268 These results demonstrate that TSH induces the formation of PKAc/IkappaB complex in FRTL-5 cells and that this PKAc bound with IkappaB plays a critical role in *dependent* activation of [p65] . Regulation SYT1 TNF 16644735 1583268 Mechanistically , our data indicated that , in *response* to , [NFkappaB/p65] phosphorylation and translocation as well as IkappaBalpha phosphorylation and degradation were unchanged , suggesting that Lnk does not modulate NFkappaB activity . Regulation SYT1 TNF 20599928 2290851 In HCT116 cells , CAPE interfered with *dependent* IkappaBalpha degradation and subsequent nuclear accumulation of [p65] , which occurred by direct inhibition of inhibitory protein kappaB kinase (IKK) . Regulation SYT1 TNF 20966395 2365261 Erg inhibited *dependent* activation of the ICAM-1 promoter , nuclear factor ( NF ) -?B activity , and NF-?B [p65] phosphorylation . Regulation SYT1 TNF 23341882 2733874 PDTC significantly inhibited the expression of MMP9 and the phosphorylation of I?Ba , as well as the expression of phosphorylation [p65] protein in *response* to ( p < 0.05 ) . Regulation SYT1 TNF 9756499 535745 *dependent* increases in hepatic nuclear factor-kappaB (NF-kappaB) p50 and [p65] expression and DNA binding activity are prevented , whereas IL-6 dependent inductions of hepatic Stat-3 phosphorylation and DNA binding activity occur normally . Regulation SYT8 CA2 12062043 953010 *dependent* [synaptotagmin] binding to SNAP-25 is essential for Ca2+ triggered exocytosis . Regulation SYT8 CA2 12062043 953074 We found that synaptotagmins I and IX associate with SNAP-25 during Ca2+ dependent exocytosis in PC12 cells , and we identified C-terminal amino acids in SNAP-25 ( Asp179 , Asp186 , Asp193 ) that are required for *dependent* [synaptotagmin] binding . Regulation SYT8 CA2 12062043 953127 These results indicate that the *dependent* interaction of [synaptotagmin] with SNAP-25 is essential for the Ca2+ dependent triggering of membrane fusion . Regulation SYT8 CA2 17715396 1806340 Gbetagamma interferes with *dependent* binding of [synaptotagmin] to the soluble N-ethylmaleimide-sensitive factor attachment protein receptor ( SNARE) complex . Regulation SYT8 CA2 17891149 1802533 *dependent* binding of [synaptotagmin] to its own membrane impedes the activation . Regulation SYT8 CA2 7559535 323912 *regulates* the interaction between [synaptotagmin] and syntaxin 1 . Regulation SYT8 CA2 8621455 359895 In contrast , a separate *dependent* interaction between [synaptotagmin] and syntaxin , a component of the fusion apparatus , occurs with an EC50 value of approximately 100 microM Ca2+ and involves the synergistic action of both C2 domains of synaptotagmin . Regulation SYT8 CA2 9405690 470402 Binding of [synaptotagmin] to the rbA isoform of alpha1A is *dependent* , with maximum affinity at 10-20 microM Ca2+ . Regulation SYT8 SV2A 20702688 2335519 In synapses , *regulates* the expression and trafficking of the calcium sensor protein [synaptotagmin] , an action consistent with the reduced calcium mediated exocytosis observed in neurons lacking SV2 . Regulation TAB1 EPHB2 14734742 1199426 Of interest , MEKK1 immunoprecipitates from IL-1 stimulated FLS appeared to activate c-Jun through the JNK pathway and [TAK1] activation of c-Jun was *dependent* on JNK , , and p38 . Regulation TAB1 IL1B 19232515 2050512 FBXW5 associated with endogenous [TAK1] in an *dependent* manner . Regulation TAB1 TNF 10187861 603066 Furthermore , activated endogenous TAK1 , and the kinase negative [TAK1] *acted* as a dominant negative inhibitor against tumor necrosis factor-alpha induced NF-kappaB activation . Regulation TAB3 TNF 14633987 1170869 Endogenous [TAB3] interacts with TRAF6 and TRAF2 in an IL-1- and a *dependent* manner , respectively . Regulation TAC1 IL1B 7859071 287102 The *effects* of on the hypothalamic [tachykinin] , neurokinin A . Regulation TAC3 IL1B 7859071 287103 The *effects* of on the hypothalamic [tachykinin] , neurokinin A . Regulation TAC4 IL1B 7859071 287104 The *effects* of on the hypothalamic [tachykinin] , neurokinin A . Regulation TACC2 STAT4 14660657 1202290 In this report , we utilize chromatin immunoprecipitation assays to analyze IL-12 stimulated and *dependent* changes in [chromatin remodeling] of the CD25 gene . Regulation TACC3 STAT4 14660657 1202291 In this report , we utilize chromatin immunoprecipitation assays to analyze IL-12 stimulated and *dependent* changes in [chromatin remodeling] of the CD25 gene . Regulation TAF1 CCND1 11126356 759610 In this study , we have examined whether *affects* the functional interaction between Rb and [TAFII250] . Regulation TAF1 IFI27 18684994 1960953 These results suggest that [TAF1] *regulates* apoptosis by controlling ( Kip1 ) expression . Regulation TANK TNF 21119000 2372293 Tumor necrosis factor a (TNF-a) receptor associated factor 2 ( [TRAF2] ) regulates activation of the c-Jun N-terminal kinase (JNK)/c-Jun and the inhibitor of ?B kinase ( IKK ) /nuclear factor ?B ( NF-?B ) signaling cascades in *response* to stimulation . Regulation TANK TNF 9774977 540126 In untransfected mammalian cells , ASK1 rapidly associates with [TRAF2] in a *dependent* manner . Regulation TAOK1 STK39 18083840 1837752 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation TAP1 TNF 15240699 1270383 These results show that LPS and *regulate* the induction of [Tap1] and Lmp2 through STAT1 , but use distinct areas of the promoter . Regulation TARDBP CAPN8 23250437 2708768 A role for *dependent* cleavage of [TDP-43] in amyotrophic lateral sclerosis pathology . Regulation TARDBP CAPN8 23250437 2708824 Additional demonstration of calpain dependent TDP43 fragments in the spinal cord and brain of amyotrophic lateral sclerosis patients , and high vulnerability of amyotrophic lateral sclerosis linked mutant TDP43 to cleavage by calpain support the crucial role of the *dependent* cleavage of [TDP43] in the amyotrophic lateral sclerosis pathology . Regulation TAS2R38 IL1B 15705185 1372753 The anti-oxidant , NAC , appears to ameliorate part of the fibrogenic *effect* of on [PTC] through mechanisms that do not significantly involve protein kinase C activation or nitric oxide release . Regulation TAT FOXA1 8101632 222641 Analyses with the dedifferentiated hepatoma cell line HTC suggested that and/or -gamma , but not HNF3 beta , are *involved* in activating the [tyrosine aminotransferase] gene via the -11-kb enhancer . Regulation TAX1BP1 TNF 21765415 2467109 The kinase IKKa , but not IKKß , was required for phosphorylation of TAX1BP1 and directly phosphorylated [TAX1BP1] in *response* to stimulation with or interleukin 1 (IL-1) . Regulation TAZ TNF 19538860 2099061 [ The *effect* of on [TAZ] expression and osteogenic potential of mesenchymal stem cells from myeloma patients ] . Regulation TBCA F2R 21241677 2397860 Treatment with the selective PAR-1 agonist , TRAP ( SFLLRN ) caused the formation of CFAs , suggesting that [CFA] formation *involved* signaling . Regulation TBCC TNF 3135864 95829 In suspension cultures , the *effect* on [L-CFC] was a function of time of exposure , particularly with low concentrations of TNF . Regulation TBCC TNF 3143710 100977 Short-term treatment of bone marrow in suspension culture for 2 hr did not affect the subsequent colony formation , suggesting that had an antiproliferative rather than a direct toxic *effect* on normal [GM-CFC] . Regulation TCEA1 C1QTNF1 9002605 404753 The results of the present work support the possible *role* of in GA-induced corolla and stem [elongation] . Regulation TCEA1 CAPN8 16824766 1672218 Based on these findings , it is concluded that the may play an important role in the *control* of notochord [elongation] and somite differentiation during Xenopus embryogenesis . Regulation TCEA1 ELOVL4 17304340 1699084 Furthermore , we suggest that is likely *involved* in the [elongation] of C26 and longer fatty acids . Regulation TCEA1 EPHB2 15067199 1231831 Here , we tested the *involvement* of the and p23 in neurite [elongation] by FK506 in human SH-SY5Y cells . Regulation TCEA1 EPHB2 15067199 1231870 Taken together , the results demonstrate the functional *role* for and p23 in the neurite [elongation] activity of FK506 and reveal a novel signal transduction pathway involving p23 activation of ERK . Regulation TCEA1 EPHB2 18676449 1955189 The splice variants of UBF differentially regulate RNA polymerase I transcription [elongation] in *response* to phosphorylation . Regulation TCEA1 IGFBP1 19497977 2120638 These studies reveal that is a common endometrial marker of conceptus elongation in sheep and cattle and most likely *regulates* conceptus [elongation] by stimulating migration and attachment of the trophectoderm . Regulation TCEA1 MIP 21642618 2451039 Considering the important known functions of the cellular actin cytoskeleton in fiber cell differentiation , the interaction of and ERM proteins may *play* an important role in fiber cell morphology , [elongation] , and organization . Regulation TCEA1 PCDH19 18171927 1855805 and TAF1 *regulate* retinal axon initiation and [elongation] in vivo . Regulation TCEA1 PCDH8 18171927 1855810 and TAF1 *regulate* retinal axon initiation and [elongation] in vivo . Regulation TCEA1 STK39 10557072 566087 The UNC-51 of C. elegans *plays* an essential role in axonal [elongation] , and unc-51 mutants exhibit uncoordinated movements . Regulation TCEA1 TMOD1 18984629 1989795 Thus , we propose a model in which and enhancers of actin dynamics synergistically *regulate* [elongation] and shortening of actin filaments at the pointed end . Regulation TCEA1 TP63 15863843 1401303 From these results , we suggest that may be *involved* in the early stage of the remodeling process of the psoriatic epidermis as well as in the [elongation] of the rete ridges . Regulation TCF12 ADRB2 15024018 1243858 To identify the mechanism responsible for this effect , we determined whether CD86 and/or stimulation *regulated* [transcription factor] expression and binding to the 3'-IgH enhancer in vitro and in vivo . Regulation TCF12 CCND1 14706452 1196359 The strong binding of E2F1 and NFkappaB is especially noteworthy , because the former [transcription factor] is *regulated* by , a downstream target of beta-catenin/TCF/LEF signaling , whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways . Regulation TCF12 CCND1 17122440 1661165 To determine whether [beta-catenin/TCF] signaling *regulates* VSMC proliferation via modulation of the beta-catenin/TCF responsive cell cycle genes , and p21 , we inhibited beta-catenin/TCF signaling by adenoviral mediated over-expression of N-Cadherin , ICAT ( an endogenous inhibitor of beta-catenin/TCF signaling ) , or a dominant negative ( dn ) mutant of TCF-4 . Regulation TCF12 EFNB1 12408869 1010308 We show here that beta-catenin and [TCF] inversely *control* the expression of the EphB2/EphB3 receptors and their ligand in colorectal cancer and along the crypt-villus axis . Regulation TCF12 EPHB2 11784711 922020 Superoxide mediates shock wave induction of *dependent* osteogenic [transcription factor] ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors . Regulation TCF12 EPHB2 11880483 919407 BDNF-LTP was further coupled to *dependent* phosphorylation of the [transcription factor] cAMP response element binding protein . Regulation TCF12 EPHB2 21890597 2506405 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and *dependent* activation of the CCAAT/enhancer binding protein beta [transcription factor] independent of p53 . Regulation TCF12 FAS 21794413 1847973 Since YY-1 down regulates Fas in cancer cell lines , it is reasonable to consider that this [transcription factor] may *control* expression in lupus nephritis . Regulation TCF12 FBXO32 16507768 1529556 The transcriptional regulation of human may be *controlled* by an Akt mediated [transcription factor] other than FKHR or via another signaling pathway . Regulation TCF12 FOLR1 24186951 2890193 It showed that in addition to aox , , and pck , RSE2 and RSE3 *regulate* the expression of genes encoding the alternative NADH dehydrogenase , a Zn2Cys6 [transcription factor] , a flavohemoglobin , and various hydrolases . Regulation TCF12 FOXO1 22550000 2669319 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced *dependent* inhibition of [Wnt/TCF] activity . Regulation TCF12 HES2 16616763 1598290 This study was designed to explore the *effects* of 130/0.4 on pulmonary capillary permeability (PCP) , production of cytokines , and activation of [transcription factor] in septic rats induced by cecal ligation and puncture (CLP) . Regulation TCF12 IL1B 15699492 1351682 Using microarray analyses , we identified several [transcription factor] and `` effector '' gene networks *regulated* by and/or interferon-gamma in beta cells . Regulation TCF12 IL1B 9950608 589801 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to , tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Regulation TCF12 TNF 10070162 594277 C2 ceramide did not mimic the *effects* of on the activation of c-Jun NH2-terminal protein kinase and nuclear factor-kappaB [transcription factor] . Regulation TCF12 TNF 11238044 790446 Electrophoretic mobility gel shift assay and immunohistochemistry for NF-kappaB in BDL tumor necrosis factor-receptor 1 knockout mice demonstrated hepatocyte NF-kappaB activation , suggesting that was not *responsible* for the activation of this [transcription factor] . Regulation TCF12 TNF 8046241 266998 This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity , but does not modulate activation of NF-kappa B [transcription factor] *controlling* the expression of various genes . Regulation TCF12 TNF 9794740 543109 To determine whether the [transcription factor] nuclear factor-kappaB mediated expression of these genes involved in the inflammatory *response* of endothelial cells to , by using transcription factor decoy oligodeoxynucleotides . Regulation TCF12 TNF 9950608 589799 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to interleukin-1beta (IL-1beta) , , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Regulation TCF12 TP63 21741828 2599110 These data identify a new transcriptional programme mediated by *regulation* of the Basonuclin 1 [transcription factor] in squamous cell carcinomas and provide a novel link of p63 with the regulation of ribosomal biogenesis in epithelial cancer . Regulation TCF15 ADRB2 15024018 1243860 To identify the mechanism responsible for this effect , we determined whether CD86 and/or stimulation *regulated* [transcription factor] expression and binding to the 3'-IgH enhancer in vitro and in vivo . Regulation TCF15 CCND1 14706452 1196360 The strong binding of E2F1 and NFkappaB is especially noteworthy , because the former [transcription factor] is *regulated* by , a downstream target of beta-catenin/TCF/LEF signaling , whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways . Regulation TCF15 CCND1 17122440 1661166 To determine whether [beta-catenin/TCF] signaling *regulates* VSMC proliferation via modulation of the beta-catenin/TCF responsive cell cycle genes , and p21 , we inhibited beta-catenin/TCF signaling by adenoviral mediated over-expression of N-Cadherin , ICAT ( an endogenous inhibitor of beta-catenin/TCF signaling ) , or a dominant negative ( dn ) mutant of TCF-4 . Regulation TCF15 EFNB1 12408869 1010309 We show here that beta-catenin and [TCF] inversely *control* the expression of the EphB2/EphB3 receptors and their ligand in colorectal cancer and along the crypt-villus axis . Regulation TCF15 EPHB2 11784711 922021 Superoxide mediates shock wave induction of *dependent* osteogenic [transcription factor] ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors . Regulation TCF15 EPHB2 11880483 919408 BDNF-LTP was further coupled to *dependent* phosphorylation of the [transcription factor] cAMP response element binding protein . Regulation TCF15 EPHB2 21890597 2506406 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and *dependent* activation of the CCAAT/enhancer binding protein beta [transcription factor] independent of p53 . Regulation TCF15 FAS 21794413 1847974 Since YY-1 down regulates Fas in cancer cell lines , it is reasonable to consider that this [transcription factor] may *control* expression in lupus nephritis . Regulation TCF15 FBXO32 16507768 1529557 The transcriptional regulation of human may be *controlled* by an Akt mediated [transcription factor] other than FKHR or via another signaling pathway . Regulation TCF15 FOLR1 24186951 2890196 It showed that in addition to aox , , and pck , RSE2 and RSE3 *regulate* the expression of genes encoding the alternative NADH dehydrogenase , a Zn2Cys6 [transcription factor] , a flavohemoglobin , and various hydrolases . Regulation TCF15 FOXO1 22550000 2669323 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced *dependent* inhibition of [Wnt/TCF] activity . Regulation TCF15 HES2 16616763 1598297 This study was designed to explore the *effects* of 130/0.4 on pulmonary capillary permeability (PCP) , production of cytokines , and activation of [transcription factor] in septic rats induced by cecal ligation and puncture (CLP) . Regulation TCF15 IL1B 15699492 1351684 Using microarray analyses , we identified several [transcription factor] and `` effector '' gene networks *regulated* by and/or interferon-gamma in beta cells . Regulation TCF15 IL1B 9950608 589804 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to , tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Regulation TCF15 TNF 10070162 594278 C2 ceramide did not mimic the *effects* of on the activation of c-Jun NH2-terminal protein kinase and nuclear factor-kappaB [transcription factor] . Regulation TCF15 TNF 11238044 790447 Electrophoretic mobility gel shift assay and immunohistochemistry for NF-kappaB in BDL tumor necrosis factor-receptor 1 knockout mice demonstrated hepatocyte NF-kappaB activation , suggesting that was not *responsible* for the activation of this [transcription factor] . Regulation TCF15 TNF 8046241 266999 This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity , but does not modulate activation of NF-kappa B [transcription factor] *controlling* the expression of various genes . Regulation TCF15 TNF 9794740 543110 To determine whether the [transcription factor] nuclear factor-kappaB mediated expression of these genes involved in the inflammatory *response* of endothelial cells to , by using transcription factor decoy oligodeoxynucleotides . Regulation TCF15 TNF 9950608 589802 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to interleukin-1beta (IL-1beta) , , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Regulation TCF15 TP63 21741828 2599111 These data identify a new transcriptional programme mediated by *regulation* of the Basonuclin 1 [transcription factor] in squamous cell carcinomas and provide a novel link of p63 with the regulation of ribosomal biogenesis in epithelial cancer . Regulation TCF19 ADRB2 15024018 1243862 To identify the mechanism responsible for this effect , we determined whether CD86 and/or stimulation *regulated* [transcription factor] expression and binding to the 3'-IgH enhancer in vitro and in vivo . Regulation TCF19 CCND1 14706452 1196361 The strong binding of E2F1 and NFkappaB is especially noteworthy , because the former [transcription factor] is *regulated* by , a downstream target of beta-catenin/TCF/LEF signaling , whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways . Regulation TCF19 CCND1 17122440 1661167 To determine whether [beta-catenin/TCF] signaling *regulates* VSMC proliferation via modulation of the beta-catenin/TCF responsive cell cycle genes , and p21 , we inhibited beta-catenin/TCF signaling by adenoviral mediated over-expression of N-Cadherin , ICAT ( an endogenous inhibitor of beta-catenin/TCF signaling ) , or a dominant negative ( dn ) mutant of TCF-4 . Regulation TCF19 EFNB1 12408869 1010310 We show here that beta-catenin and [TCF] inversely *control* the expression of the EphB2/EphB3 receptors and their ligand in colorectal cancer and along the crypt-villus axis . Regulation TCF19 EPHB2 11784711 922022 Superoxide mediates shock wave induction of *dependent* osteogenic [transcription factor] ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors . Regulation TCF19 EPHB2 11880483 919409 BDNF-LTP was further coupled to *dependent* phosphorylation of the [transcription factor] cAMP response element binding protein . Regulation TCF19 EPHB2 21890597 2506407 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and *dependent* activation of the CCAAT/enhancer binding protein beta [transcription factor] independent of p53 . Regulation TCF19 FAS 21794413 1847975 Since YY-1 down regulates Fas in cancer cell lines , it is reasonable to consider that this [transcription factor] may *control* expression in lupus nephritis . Regulation TCF19 FBXO32 16507768 1529558 The transcriptional regulation of human may be *controlled* by an Akt mediated [transcription factor] other than FKHR or via another signaling pathway . Regulation TCF19 FOLR1 24186951 2890199 It showed that in addition to aox , , and pck , RSE2 and RSE3 *regulate* the expression of genes encoding the alternative NADH dehydrogenase , a Zn2Cys6 [transcription factor] , a flavohemoglobin , and various hydrolases . Regulation TCF19 FOXO1 22550000 2669327 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced *dependent* inhibition of [Wnt/TCF] activity . Regulation TCF19 HES2 16616763 1598304 This study was designed to explore the *effects* of 130/0.4 on pulmonary capillary permeability (PCP) , production of cytokines , and activation of [transcription factor] in septic rats induced by cecal ligation and puncture (CLP) . Regulation TCF19 IL1B 15699492 1351686 Using microarray analyses , we identified several [transcription factor] and `` effector '' gene networks *regulated* by and/or interferon-gamma in beta cells . Regulation TCF19 IL1B 9950608 589807 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to , tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Regulation TCF19 TNF 10070162 594279 C2 ceramide did not mimic the *effects* of on the activation of c-Jun NH2-terminal protein kinase and nuclear factor-kappaB [transcription factor] . Regulation TCF19 TNF 11238044 790448 Electrophoretic mobility gel shift assay and immunohistochemistry for NF-kappaB in BDL tumor necrosis factor-receptor 1 knockout mice demonstrated hepatocyte NF-kappaB activation , suggesting that was not *responsible* for the activation of this [transcription factor] . Regulation TCF19 TNF 8046241 267000 This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity , but does not modulate activation of NF-kappa B [transcription factor] *controlling* the expression of various genes . Regulation TCF19 TNF 9794740 543111 To determine whether the [transcription factor] nuclear factor-kappaB mediated expression of these genes involved in the inflammatory *response* of endothelial cells to , by using transcription factor decoy oligodeoxynucleotides . Regulation TCF19 TNF 9950608 589805 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to interleukin-1beta (IL-1beta) , , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Regulation TCF19 TP63 21741828 2599112 These data identify a new transcriptional programme mediated by *regulation* of the Basonuclin 1 [transcription factor] in squamous cell carcinomas and provide a novel link of p63 with the regulation of ribosomal biogenesis in epithelial cancer . Regulation TCF20 ADRB2 15024018 1243864 To identify the mechanism responsible for this effect , we determined whether CD86 and/or stimulation *regulated* [transcription factor] expression and binding to the 3'-IgH enhancer in vitro and in vivo . Regulation TCF20 CCND1 14706452 1196362 The strong binding of E2F1 and NFkappaB is especially noteworthy , because the former [transcription factor] is *regulated* by , a downstream target of beta-catenin/TCF/LEF signaling , whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways . Regulation TCF20 CCND1 17122440 1661168 To determine whether [beta-catenin/TCF] signaling *regulates* VSMC proliferation via modulation of the beta-catenin/TCF responsive cell cycle genes , and p21 , we inhibited beta-catenin/TCF signaling by adenoviral mediated over-expression of N-Cadherin , ICAT ( an endogenous inhibitor of beta-catenin/TCF signaling ) , or a dominant negative ( dn ) mutant of TCF-4 . Regulation TCF20 EFNB1 12408869 1010311 We show here that beta-catenin and [TCF] inversely *control* the expression of the EphB2/EphB3 receptors and their ligand in colorectal cancer and along the crypt-villus axis . Regulation TCF20 EPHB2 11784711 922023 Superoxide mediates shock wave induction of *dependent* osteogenic [transcription factor] ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors . Regulation TCF20 EPHB2 11880483 919410 BDNF-LTP was further coupled to *dependent* phosphorylation of the [transcription factor] cAMP response element binding protein . Regulation TCF20 EPHB2 21890597 2506408 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and *dependent* activation of the CCAAT/enhancer binding protein beta [transcription factor] independent of p53 . Regulation TCF20 FAS 21794413 1847976 Since YY-1 down regulates Fas in cancer cell lines , it is reasonable to consider that this [transcription factor] may *control* expression in lupus nephritis . Regulation TCF20 FBXO32 16507768 1529559 The transcriptional regulation of human may be *controlled* by an Akt mediated [transcription factor] other than FKHR or via another signaling pathway . Regulation TCF20 FOLR1 24186951 2890202 It showed that in addition to aox , , and pck , RSE2 and RSE3 *regulate* the expression of genes encoding the alternative NADH dehydrogenase , a Zn2Cys6 [transcription factor] , a flavohemoglobin , and various hydrolases . Regulation TCF20 FOXO1 22550000 2669331 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced *dependent* inhibition of [Wnt/TCF] activity . Regulation TCF20 HES2 16616763 1598311 This study was designed to explore the *effects* of 130/0.4 on pulmonary capillary permeability (PCP) , production of cytokines , and activation of [transcription factor] in septic rats induced by cecal ligation and puncture (CLP) . Regulation TCF20 IL1B 15699492 1351688 Using microarray analyses , we identified several [transcription factor] and `` effector '' gene networks *regulated* by and/or interferon-gamma in beta cells . Regulation TCF20 IL1B 9950608 589810 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to , tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Regulation TCF20 TNF 10070162 594280 C2 ceramide did not mimic the *effects* of on the activation of c-Jun NH2-terminal protein kinase and nuclear factor-kappaB [transcription factor] . Regulation TCF20 TNF 11238044 790449 Electrophoretic mobility gel shift assay and immunohistochemistry for NF-kappaB in BDL tumor necrosis factor-receptor 1 knockout mice demonstrated hepatocyte NF-kappaB activation , suggesting that was not *responsible* for the activation of this [transcription factor] . Regulation TCF20 TNF 8046241 267001 This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity , but does not modulate activation of NF-kappa B [transcription factor] *controlling* the expression of various genes . Regulation TCF20 TNF 9794740 543112 To determine whether the [transcription factor] nuclear factor-kappaB mediated expression of these genes involved in the inflammatory *response* of endothelial cells to , by using transcription factor decoy oligodeoxynucleotides . Regulation TCF20 TNF 9950608 589808 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to interleukin-1beta (IL-1beta) , , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Regulation TCF20 TP63 21741828 2599113 These data identify a new transcriptional programme mediated by *regulation* of the Basonuclin 1 [transcription factor] in squamous cell carcinomas and provide a novel link of p63 with the regulation of ribosomal biogenesis in epithelial cancer . Regulation TCF21 ADRB2 15024018 1243866 To identify the mechanism responsible for this effect , we determined whether CD86 and/or stimulation *regulated* [transcription factor] expression and binding to the 3'-IgH enhancer in vitro and in vivo . Regulation TCF21 CCND1 14706452 1196363 The strong binding of E2F1 and NFkappaB is especially noteworthy , because the former [transcription factor] is *regulated* by , a downstream target of beta-catenin/TCF/LEF signaling , whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways . Regulation TCF21 CCND1 17122440 1661169 To determine whether [beta-catenin/TCF] signaling *regulates* VSMC proliferation via modulation of the beta-catenin/TCF responsive cell cycle genes , and p21 , we inhibited beta-catenin/TCF signaling by adenoviral mediated over-expression of N-Cadherin , ICAT ( an endogenous inhibitor of beta-catenin/TCF signaling ) , or a dominant negative ( dn ) mutant of TCF-4 . Regulation TCF21 EFNB1 12408869 1010312 We show here that beta-catenin and [TCF] inversely *control* the expression of the EphB2/EphB3 receptors and their ligand in colorectal cancer and along the crypt-villus axis . Regulation TCF21 EPHB2 11784711 922024 Superoxide mediates shock wave induction of *dependent* osteogenic [transcription factor] ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors . Regulation TCF21 EPHB2 11880483 919411 BDNF-LTP was further coupled to *dependent* phosphorylation of the [transcription factor] cAMP response element binding protein . Regulation TCF21 EPHB2 21890597 2506409 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and *dependent* activation of the CCAAT/enhancer binding protein beta [transcription factor] independent of p53 . Regulation TCF21 FAS 21794413 1847977 Since YY-1 down regulates Fas in cancer cell lines , it is reasonable to consider that this [transcription factor] may *control* expression in lupus nephritis . Regulation TCF21 FBXO32 16507768 1529560 The transcriptional regulation of human may be *controlled* by an Akt mediated [transcription factor] other than FKHR or via another signaling pathway . Regulation TCF21 FOLR1 24186951 2890205 It showed that in addition to aox , , and pck , RSE2 and RSE3 *regulate* the expression of genes encoding the alternative NADH dehydrogenase , a Zn2Cys6 [transcription factor] , a flavohemoglobin , and various hydrolases . Regulation TCF21 FOXO1 22550000 2669335 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced *dependent* inhibition of [Wnt/TCF] activity . Regulation TCF21 HES2 16616763 1598318 This study was designed to explore the *effects* of 130/0.4 on pulmonary capillary permeability (PCP) , production of cytokines , and activation of [transcription factor] in septic rats induced by cecal ligation and puncture (CLP) . Regulation TCF21 IL1B 15699492 1351690 Using microarray analyses , we identified several [transcription factor] and `` effector '' gene networks *regulated* by and/or interferon-gamma in beta cells . Regulation TCF21 IL1B 9950608 589813 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to , tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Regulation TCF21 TNF 10070162 594281 C2 ceramide did not mimic the *effects* of on the activation of c-Jun NH2-terminal protein kinase and nuclear factor-kappaB [transcription factor] . Regulation TCF21 TNF 11238044 790450 Electrophoretic mobility gel shift assay and immunohistochemistry for NF-kappaB in BDL tumor necrosis factor-receptor 1 knockout mice demonstrated hepatocyte NF-kappaB activation , suggesting that was not *responsible* for the activation of this [transcription factor] . Regulation TCF21 TNF 8046241 267002 This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity , but does not modulate activation of NF-kappa B [transcription factor] *controlling* the expression of various genes . Regulation TCF21 TNF 9794740 543113 To determine whether the [transcription factor] nuclear factor-kappaB mediated expression of these genes involved in the inflammatory *response* of endothelial cells to , by using transcription factor decoy oligodeoxynucleotides . Regulation TCF21 TNF 9950608 589811 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to interleukin-1beta (IL-1beta) , , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Regulation TCF21 TP63 21741828 2599114 These data identify a new transcriptional programme mediated by *regulation* of the Basonuclin 1 [transcription factor] in squamous cell carcinomas and provide a novel link of p63 with the regulation of ribosomal biogenesis in epithelial cancer . Regulation TCF23 ADRB2 15024018 1243874 To identify the mechanism responsible for this effect , we determined whether CD86 and/or stimulation *regulated* [transcription factor] expression and binding to the 3'-IgH enhancer in vitro and in vivo . Regulation TCF23 CCND1 14706452 1196367 The strong binding of E2F1 and NFkappaB is especially noteworthy , because the former [transcription factor] is *regulated* by , a downstream target of beta-catenin/TCF/LEF signaling , whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways . Regulation TCF23 CCND1 17122440 1661173 To determine whether [beta-catenin/TCF] signaling *regulates* VSMC proliferation via modulation of the beta-catenin/TCF responsive cell cycle genes , and p21 , we inhibited beta-catenin/TCF signaling by adenoviral mediated over-expression of N-Cadherin , ICAT ( an endogenous inhibitor of beta-catenin/TCF signaling ) , or a dominant negative ( dn ) mutant of TCF-4 . Regulation TCF23 EFNB1 12408869 1010316 We show here that beta-catenin and [TCF] inversely *control* the expression of the EphB2/EphB3 receptors and their ligand in colorectal cancer and along the crypt-villus axis . Regulation TCF23 EPHB2 11784711 922028 Superoxide mediates shock wave induction of *dependent* osteogenic [transcription factor] ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors . Regulation TCF23 EPHB2 11880483 919415 BDNF-LTP was further coupled to *dependent* phosphorylation of the [transcription factor] cAMP response element binding protein . Regulation TCF23 EPHB2 21890597 2506414 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and *dependent* activation of the CCAAT/enhancer binding protein beta [transcription factor] independent of p53 . Regulation TCF23 FAS 21794413 1847993 Since YY-1 down regulates Fas in cancer cell lines , it is reasonable to consider that this [transcription factor] may *control* expression in lupus nephritis . Regulation TCF23 FBXO32 16507768 1529575 The transcriptional regulation of human may be *controlled* by an Akt mediated [transcription factor] other than FKHR or via another signaling pathway . Regulation TCF23 FOLR1 24186951 2890219 It showed that in addition to aox , , and pck , RSE2 and RSE3 *regulate* the expression of genes encoding the alternative NADH dehydrogenase , a Zn2Cys6 [transcription factor] , a flavohemoglobin , and various hydrolases . Regulation TCF23 FOXO1 22550000 2669379 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced *dependent* inhibition of [Wnt/TCF] activity . Regulation TCF23 HES2 16616763 1598346 This study was designed to explore the *effects* of 130/0.4 on pulmonary capillary permeability (PCP) , production of cytokines , and activation of [transcription factor] in septic rats induced by cecal ligation and puncture (CLP) . Regulation TCF23 IL1B 15699492 1351698 Using microarray analyses , we identified several [transcription factor] and `` effector '' gene networks *regulated* by and/or interferon-gamma in beta cells . Regulation TCF23 IL1B 9950608 589825 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to , tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Regulation TCF23 TNF 10070162 594285 C2 ceramide did not mimic the *effects* of on the activation of c-Jun NH2-terminal protein kinase and nuclear factor-kappaB [transcription factor] . Regulation TCF23 TNF 11238044 790454 Electrophoretic mobility gel shift assay and immunohistochemistry for NF-kappaB in BDL tumor necrosis factor-receptor 1 knockout mice demonstrated hepatocyte NF-kappaB activation , suggesting that was not *responsible* for the activation of this [transcription factor] . Regulation TCF23 TNF 8046241 267017 This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity , but does not modulate activation of NF-kappa B [transcription factor] *controlling* the expression of various genes . Regulation TCF23 TNF 9794740 543117 To determine whether the [transcription factor] nuclear factor-kappaB mediated expression of these genes involved in the inflammatory *response* of endothelial cells to , by using transcription factor decoy oligodeoxynucleotides . Regulation TCF23 TNF 9950608 589823 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to interleukin-1beta (IL-1beta) , , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Regulation TCF23 TP63 21741828 2599118 These data identify a new transcriptional programme mediated by *regulation* of the Basonuclin 1 [transcription factor] in squamous cell carcinomas and provide a novel link of p63 with the regulation of ribosomal biogenesis in epithelial cancer . Regulation TCF24 ADRB2 15024018 1243878 To identify the mechanism responsible for this effect , we determined whether CD86 and/or stimulation *regulated* [transcription factor] expression and binding to the 3'-IgH enhancer in vitro and in vivo . Regulation TCF24 CCND1 14706452 1196369 The strong binding of E2F1 and NFkappaB is especially noteworthy , because the former [transcription factor] is *regulated* by , a downstream target of beta-catenin/TCF/LEF signaling , whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways . Regulation TCF24 CCND1 17122440 1661176 To determine whether [beta-catenin/TCF] signaling *regulates* VSMC proliferation via modulation of the beta-catenin/TCF responsive cell cycle genes , and p21 , we inhibited beta-catenin/TCF signaling by adenoviral mediated over-expression of N-Cadherin , ICAT ( an endogenous inhibitor of beta-catenin/TCF signaling ) , or a dominant negative ( dn ) mutant of TCF-4 . Regulation TCF24 EFNB1 12408869 1010331 We show here that beta-catenin and [TCF] inversely *control* the expression of the EphB2/EphB3 receptors and their ligand in colorectal cancer and along the crypt-villus axis . Regulation TCF24 EPHB2 11784711 922030 Superoxide mediates shock wave induction of *dependent* osteogenic [transcription factor] ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors . Regulation TCF24 EPHB2 11880483 919417 BDNF-LTP was further coupled to *dependent* phosphorylation of the [transcription factor] cAMP response element binding protein . Regulation TCF24 EPHB2 21890597 2506416 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and *dependent* activation of the CCAAT/enhancer binding protein beta [transcription factor] independent of p53 . Regulation TCF24 FAS 21794413 1847995 Since YY-1 down regulates Fas in cancer cell lines , it is reasonable to consider that this [transcription factor] may *control* expression in lupus nephritis . Regulation TCF24 FBXO32 16507768 1529577 The transcriptional regulation of human may be *controlled* by an Akt mediated [transcription factor] other than FKHR or via another signaling pathway . Regulation TCF24 FOLR1 24186951 2890225 It showed that in addition to aox , , and pck , RSE2 and RSE3 *regulate* the expression of genes encoding the alternative NADH dehydrogenase , a Zn2Cys6 [transcription factor] , a flavohemoglobin , and various hydrolases . Regulation TCF24 FOXO1 22550000 2669387 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced *dependent* inhibition of [Wnt/TCF] activity . Regulation TCF24 HES2 16616763 1598360 This study was designed to explore the *effects* of 130/0.4 on pulmonary capillary permeability (PCP) , production of cytokines , and activation of [transcription factor] in septic rats induced by cecal ligation and puncture (CLP) . Regulation TCF24 IL1B 15699492 1351702 Using microarray analyses , we identified several [transcription factor] and `` effector '' gene networks *regulated* by and/or interferon-gamma in beta cells . Regulation TCF24 IL1B 9950608 589831 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to , tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Regulation TCF24 TNF 10070162 594287 C2 ceramide did not mimic the *effects* of on the activation of c-Jun NH2-terminal protein kinase and nuclear factor-kappaB [transcription factor] . Regulation TCF24 TNF 11238044 790456 Electrophoretic mobility gel shift assay and immunohistochemistry for NF-kappaB in BDL tumor necrosis factor-receptor 1 knockout mice demonstrated hepatocyte NF-kappaB activation , suggesting that was not *responsible* for the activation of this [transcription factor] . Regulation TCF24 TNF 8046241 267019 This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity , but does not modulate activation of NF-kappa B [transcription factor] *controlling* the expression of various genes . Regulation TCF24 TNF 9794740 543119 To determine whether the [transcription factor] nuclear factor-kappaB mediated expression of these genes involved in the inflammatory *response* of endothelial cells to , by using transcription factor decoy oligodeoxynucleotides . Regulation TCF24 TNF 9950608 589829 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to interleukin-1beta (IL-1beta) , , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Regulation TCF24 TP63 21741828 2599120 These data identify a new transcriptional programme mediated by *regulation* of the Basonuclin 1 [transcription factor] in squamous cell carcinomas and provide a novel link of p63 with the regulation of ribosomal biogenesis in epithelial cancer . Regulation TCF25 ADRB2 15024018 1243876 To identify the mechanism responsible for this effect , we determined whether CD86 and/or stimulation *regulated* [transcription factor] expression and binding to the 3'-IgH enhancer in vitro and in vivo . Regulation TCF25 CCND1 14706452 1196368 The strong binding of E2F1 and NFkappaB is especially noteworthy , because the former [transcription factor] is *regulated* by , a downstream target of beta-catenin/TCF/LEF signaling , whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways . Regulation TCF25 CCND1 17122440 1661175 To determine whether [beta-catenin/TCF] signaling *regulates* VSMC proliferation via modulation of the beta-catenin/TCF responsive cell cycle genes , and p21 , we inhibited beta-catenin/TCF signaling by adenoviral mediated over-expression of N-Cadherin , ICAT ( an endogenous inhibitor of beta-catenin/TCF signaling ) , or a dominant negative ( dn ) mutant of TCF-4 . Regulation TCF25 EFNB1 12408869 1010318 We show here that beta-catenin and [TCF] inversely *control* the expression of the EphB2/EphB3 receptors and their ligand in colorectal cancer and along the crypt-villus axis . Regulation TCF25 EPHB2 11784711 922029 Superoxide mediates shock wave induction of *dependent* osteogenic [transcription factor] ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors . Regulation TCF25 EPHB2 11880483 919416 BDNF-LTP was further coupled to *dependent* phosphorylation of the [transcription factor] cAMP response element binding protein . Regulation TCF25 EPHB2 21890597 2506415 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and *dependent* activation of the CCAAT/enhancer binding protein beta [transcription factor] independent of p53 . Regulation TCF25 FAS 21794413 1847994 Since YY-1 down regulates Fas in cancer cell lines , it is reasonable to consider that this [transcription factor] may *control* expression in lupus nephritis . Regulation TCF25 FBXO32 16507768 1529576 The transcriptional regulation of human may be *controlled* by an Akt mediated [transcription factor] other than FKHR or via another signaling pathway . Regulation TCF25 FOLR1 24186951 2890222 It showed that in addition to aox , , and pck , RSE2 and RSE3 *regulate* the expression of genes encoding the alternative NADH dehydrogenase , a Zn2Cys6 [transcription factor] , a flavohemoglobin , and various hydrolases . Regulation TCF25 FOXO1 22550000 2669383 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced *dependent* inhibition of [Wnt/TCF] activity . Regulation TCF25 HES2 16616763 1598353 This study was designed to explore the *effects* of 130/0.4 on pulmonary capillary permeability (PCP) , production of cytokines , and activation of [transcription factor] in septic rats induced by cecal ligation and puncture (CLP) . Regulation TCF25 IL1B 15699492 1351700 Using microarray analyses , we identified several [transcription factor] and `` effector '' gene networks *regulated* by and/or interferon-gamma in beta cells . Regulation TCF25 IL1B 9950608 589828 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to , tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Regulation TCF25 TNF 10070162 594286 C2 ceramide did not mimic the *effects* of on the activation of c-Jun NH2-terminal protein kinase and nuclear factor-kappaB [transcription factor] . Regulation TCF25 TNF 11238044 790455 Electrophoretic mobility gel shift assay and immunohistochemistry for NF-kappaB in BDL tumor necrosis factor-receptor 1 knockout mice demonstrated hepatocyte NF-kappaB activation , suggesting that was not *responsible* for the activation of this [transcription factor] . Regulation TCF25 TNF 8046241 267018 This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity , but does not modulate activation of NF-kappa B [transcription factor] *controlling* the expression of various genes . Regulation TCF25 TNF 9794740 543118 To determine whether the [transcription factor] nuclear factor-kappaB mediated expression of these genes involved in the inflammatory *response* of endothelial cells to , by using transcription factor decoy oligodeoxynucleotides . Regulation TCF25 TNF 9950608 589826 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to interleukin-1beta (IL-1beta) , , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Regulation TCF25 TP63 21741828 2599119 These data identify a new transcriptional programme mediated by *regulation* of the Basonuclin 1 [transcription factor] in squamous cell carcinomas and provide a novel link of p63 with the regulation of ribosomal biogenesis in epithelial cancer . Regulation TCF3 ADRB2 15024018 1243868 To identify the mechanism responsible for this effect , we determined whether CD86 and/or stimulation *regulated* [transcription factor] expression and binding to the 3'-IgH enhancer in vitro and in vivo . Regulation TCF3 CCND1 14706452 1196364 The strong binding of E2F1 and NFkappaB is especially noteworthy , because the former [transcription factor] is *regulated* by , a downstream target of beta-catenin/TCF/LEF signaling , whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways . Regulation TCF3 CCND1 17122440 1661170 To determine whether [beta-catenin/TCF] signaling *regulates* VSMC proliferation via modulation of the beta-catenin/TCF responsive cell cycle genes , and p21 , we inhibited beta-catenin/TCF signaling by adenoviral mediated over-expression of N-Cadherin , ICAT ( an endogenous inhibitor of beta-catenin/TCF signaling ) , or a dominant negative ( dn ) mutant of TCF-4 . Regulation TCF3 EFNB1 12408869 1010313 We show here that beta-catenin and [TCF] inversely *control* the expression of the EphB2/EphB3 receptors and their ligand in colorectal cancer and along the crypt-villus axis . Regulation TCF3 EPHB2 11784711 922025 Superoxide mediates shock wave induction of *dependent* osteogenic [transcription factor] ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors . Regulation TCF3 EPHB2 11880483 919412 BDNF-LTP was further coupled to *dependent* phosphorylation of the [transcription factor] cAMP response element binding protein . Regulation TCF3 EPHB2 21890597 2506410 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and *dependent* activation of the CCAAT/enhancer binding protein beta [transcription factor] independent of p53 . Regulation TCF3 FAS 21794413 1847978 Since YY-1 down regulates Fas in cancer cell lines , it is reasonable to consider that this [transcription factor] may *control* expression in lupus nephritis . Regulation TCF3 FBXO32 16507768 1529561 The transcriptional regulation of human may be *controlled* by an Akt mediated [transcription factor] other than FKHR or via another signaling pathway . Regulation TCF3 FOLR1 24186951 2890208 It showed that in addition to aox , , and pck , RSE2 and RSE3 *regulate* the expression of genes encoding the alternative NADH dehydrogenase , a Zn2Cys6 [transcription factor] , a flavohemoglobin , and various hydrolases . Regulation TCF3 FOXO1 22550000 2669339 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced *dependent* inhibition of [Wnt/TCF] activity . Regulation TCF3 HES2 16616763 1598325 This study was designed to explore the *effects* of 130/0.4 on pulmonary capillary permeability (PCP) , production of cytokines , and activation of [transcription factor] in septic rats induced by cecal ligation and puncture (CLP) . Regulation TCF3 IL1B 15699492 1351692 Using microarray analyses , we identified several [transcription factor] and `` effector '' gene networks *regulated* by and/or interferon-gamma in beta cells . Regulation TCF3 IL1B 9950608 589816 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to , tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Regulation TCF3 TNF 10070162 594282 C2 ceramide did not mimic the *effects* of on the activation of c-Jun NH2-terminal protein kinase and nuclear factor-kappaB [transcription factor] . Regulation TCF3 TNF 11238044 790451 Electrophoretic mobility gel shift assay and immunohistochemistry for NF-kappaB in BDL tumor necrosis factor-receptor 1 knockout mice demonstrated hepatocyte NF-kappaB activation , suggesting that was not *responsible* for the activation of this [transcription factor] . Regulation TCF3 TNF 8046241 267003 This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity , but does not modulate activation of NF-kappa B [transcription factor] *controlling* the expression of various genes . Regulation TCF3 TNF 9794740 543114 To determine whether the [transcription factor] nuclear factor-kappaB mediated expression of these genes involved in the inflammatory *response* of endothelial cells to , by using transcription factor decoy oligodeoxynucleotides . Regulation TCF3 TNF 9950608 589814 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to interleukin-1beta (IL-1beta) , , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Regulation TCF3 TP63 21741828 2599115 These data identify a new transcriptional programme mediated by *regulation* of the Basonuclin 1 [transcription factor] in squamous cell carcinomas and provide a novel link of p63 with the regulation of ribosomal biogenesis in epithelial cancer . Regulation TCF4 ADRB2 15024018 1243870 To identify the mechanism responsible for this effect , we determined whether CD86 and/or stimulation *regulated* [transcription factor] expression and binding to the 3'-IgH enhancer in vitro and in vivo . Regulation TCF4 CCND1 14706452 1196365 The strong binding of E2F1 and NFkappaB is especially noteworthy , because the former [transcription factor] is *regulated* by , a downstream target of beta-catenin/TCF/LEF signaling , whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways . Regulation TCF4 CCND1 17122440 1661171 To determine whether [beta-catenin/TCF] signaling *regulates* VSMC proliferation via modulation of the beta-catenin/TCF responsive cell cycle genes , and p21 , we inhibited beta-catenin/TCF signaling by adenoviral mediated over-expression of N-Cadherin , ICAT ( an endogenous inhibitor of beta-catenin/TCF signaling ) , or a dominant negative ( dn ) mutant of TCF-4 . Regulation TCF4 EFNB1 12408869 1010314 We show here that beta-catenin and [TCF] inversely *control* the expression of the EphB2/EphB3 receptors and their ligand in colorectal cancer and along the crypt-villus axis . Regulation TCF4 EPHB2 11784711 922026 Superoxide mediates shock wave induction of *dependent* osteogenic [transcription factor] ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors . Regulation TCF4 EPHB2 11880483 919413 BDNF-LTP was further coupled to *dependent* phosphorylation of the [transcription factor] cAMP response element binding protein . Regulation TCF4 EPHB2 21890597 2506411 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and *dependent* activation of the CCAAT/enhancer binding protein beta [transcription factor] independent of p53 . Regulation TCF4 FAS 21794413 1847979 Since YY-1 down regulates Fas in cancer cell lines , it is reasonable to consider that this [transcription factor] may *control* expression in lupus nephritis . Regulation TCF4 FBXO32 16507768 1529562 The transcriptional regulation of human may be *controlled* by an Akt mediated [transcription factor] other than FKHR or via another signaling pathway . Regulation TCF4 FOLR1 24186951 2890211 It showed that in addition to aox , , and pck , RSE2 and RSE3 *regulate* the expression of genes encoding the alternative NADH dehydrogenase , a Zn2Cys6 [transcription factor] , a flavohemoglobin , and various hydrolases . Regulation TCF4 FOXO1 22550000 2669343 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced *dependent* inhibition of [Wnt/TCF] activity . Regulation TCF4 HES2 16616763 1598332 This study was designed to explore the *effects* of 130/0.4 on pulmonary capillary permeability (PCP) , production of cytokines , and activation of [transcription factor] in septic rats induced by cecal ligation and puncture (CLP) . Regulation TCF4 IL1B 15699492 1351694 Using microarray analyses , we identified several [transcription factor] and `` effector '' gene networks *regulated* by and/or interferon-gamma in beta cells . Regulation TCF4 IL1B 9950608 589819 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to , tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Regulation TCF4 TNF 10070162 594283 C2 ceramide did not mimic the *effects* of on the activation of c-Jun NH2-terminal protein kinase and nuclear factor-kappaB [transcription factor] . Regulation TCF4 TNF 11238044 790452 Electrophoretic mobility gel shift assay and immunohistochemistry for NF-kappaB in BDL tumor necrosis factor-receptor 1 knockout mice demonstrated hepatocyte NF-kappaB activation , suggesting that was not *responsible* for the activation of this [transcription factor] . Regulation TCF4 TNF 8046241 267004 This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity , but does not modulate activation of NF-kappa B [transcription factor] *controlling* the expression of various genes . Regulation TCF4 TNF 9794740 543115 To determine whether the [transcription factor] nuclear factor-kappaB mediated expression of these genes involved in the inflammatory *response* of endothelial cells to , by using transcription factor decoy oligodeoxynucleotides . Regulation TCF4 TNF 9950608 589817 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to interleukin-1beta (IL-1beta) , , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Regulation TCF4 TP63 21741828 2599116 These data identify a new transcriptional programme mediated by *regulation* of the Basonuclin 1 [transcription factor] in squamous cell carcinomas and provide a novel link of p63 with the regulation of ribosomal biogenesis in epithelial cancer . Regulation TCF7 ADRB2 15024018 1243872 To identify the mechanism responsible for this effect , we determined whether CD86 and/or stimulation *regulated* [transcription factor] expression and binding to the 3'-IgH enhancer in vitro and in vivo . Regulation TCF7 CCND1 14706452 1196366 The strong binding of E2F1 and NFkappaB is especially noteworthy , because the former [transcription factor] is *regulated* by , a downstream target of beta-catenin/TCF/LEF signaling , whereas the latter transcription factor has been implicated in `` cross talk '' between the Wnt and the NFkappaB signaling pathways . Regulation TCF7 CCND1 17122440 1661172 To determine whether [beta-catenin/TCF] signaling *regulates* VSMC proliferation via modulation of the beta-catenin/TCF responsive cell cycle genes , and p21 , we inhibited beta-catenin/TCF signaling by adenoviral mediated over-expression of N-Cadherin , ICAT ( an endogenous inhibitor of beta-catenin/TCF signaling ) , or a dominant negative ( dn ) mutant of TCF-4 . Regulation TCF7 EFNB1 12408869 1010315 We show here that beta-catenin and [TCF] inversely *control* the expression of the EphB2/EphB3 receptors and their ligand in colorectal cancer and along the crypt-villus axis . Regulation TCF7 EPHB2 11784711 922027 Superoxide mediates shock wave induction of *dependent* osteogenic [transcription factor] ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors . Regulation TCF7 EPHB2 11880483 919414 BDNF-LTP was further coupled to *dependent* phosphorylation of the [transcription factor] cAMP response element binding protein . Regulation TCF7 EPHB2 21890597 2506412 LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and *dependent* activation of the CCAAT/enhancer binding protein beta [transcription factor] independent of p53 . Regulation TCF7 FAS 21794413 1847980 Since YY-1 down regulates Fas in cancer cell lines , it is reasonable to consider that this [transcription factor] may *control* expression in lupus nephritis . Regulation TCF7 FBXO32 16507768 1529563 The transcriptional regulation of human may be *controlled* by an Akt mediated [transcription factor] other than FKHR or via another signaling pathway . Regulation TCF7 FOLR1 24186951 2890214 It showed that in addition to aox , , and pck , RSE2 and RSE3 *regulate* the expression of genes encoding the alternative NADH dehydrogenase , a Zn2Cys6 [transcription factor] , a flavohemoglobin , and various hydrolases . Regulation TCF7 FOXO1 22550000 2669347 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced *dependent* inhibition of [Wnt/TCF] activity . Regulation TCF7 HES2 16616763 1598339 This study was designed to explore the *effects* of 130/0.4 on pulmonary capillary permeability (PCP) , production of cytokines , and activation of [transcription factor] in septic rats induced by cecal ligation and puncture (CLP) . Regulation TCF7 IL1B 15699492 1351696 Using microarray analyses , we identified several [transcription factor] and `` effector '' gene networks *regulated* by and/or interferon-gamma in beta cells . Regulation TCF7 IL1B 9950608 589822 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to , tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Regulation TCF7 TNF 10070162 594284 C2 ceramide did not mimic the *effects* of on the activation of c-Jun NH2-terminal protein kinase and nuclear factor-kappaB [transcription factor] . Regulation TCF7 TNF 11238044 790453 Electrophoretic mobility gel shift assay and immunohistochemistry for NF-kappaB in BDL tumor necrosis factor-receptor 1 knockout mice demonstrated hepatocyte NF-kappaB activation , suggesting that was not *responsible* for the activation of this [transcription factor] . Regulation TCF7 TNF 8046241 267005 This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity , but does not modulate activation of NF-kappa B [transcription factor] *controlling* the expression of various genes . Regulation TCF7 TNF 9794740 543116 To determine whether the [transcription factor] nuclear factor-kappaB mediated expression of these genes involved in the inflammatory *response* of endothelial cells to , by using transcription factor decoy oligodeoxynucleotides . Regulation TCF7 TNF 9950608 589820 To determine whether nuclear [transcription factor-kappaB] ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in *response* to interleukin-1beta (IL-1beta) , , or interferon-gamma (IFN-gamma) alone or in combination and if so , whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor , MG-132 , which inhibits the degradation of I kappaB , an NF-kappaB inhibitor , thereby preventing nuclear translocation of NF-kappaB . Regulation TCF7 TP63 21741828 2599117 These data identify a new transcriptional programme mediated by *regulation* of the Basonuclin 1 [transcription factor] in squamous cell carcinomas and provide a novel link of p63 with the regulation of ribosomal biogenesis in epithelial cancer . Regulation TCF7L2 ZIC2 21908606 2496740 However , the binding of [TCF4] to DNA was not *affected* by . Regulation TCHP EPHB2 15880691 1432976 Recent studies have shown that mediated signals *play* a major role in regulation of activity of p53 [tumor suppressor protein] . Regulation TCHP MAP2K6 15880691 1432982 Recent studies have shown that mediated signals *play* a major role in regulation of activity of p53 [tumor suppressor protein] . Regulation TCN1 AFP 20087354 2206044 [Tc1] *responses* were detected in 28.5 % of controls , as well as in 25 % of HCC patients with Okuda I ( early tumour stage ) and in 31.6 % of HCC patients with stage II or III ( late tumour stages ) . Regulation TCN1 AFP 20087354 2206052 These results suggest that anti-AFP Th1 responses are more likely to be present in patients who are in an early stage of disease ( for both tumour stage and liver cirrhosis ) , whereas [Tc1] *responses* are more likely to be present in patients with late-stage liver cirrhosis . Regulation TCN1 CD4 10910289 713964 Here , we compared the capacity of in vitro generated normal liver immature DC and FL-treated donor liver DC to induce alloimmune T helper (Th) 1/Th2 and CD8+ [T cytotoxic (Tc) 1/Tc2] *responses* , in vitro and in vivo . Regulation TCN1 CD4 15557623 1340869 IL-12 p40 levels in serum and magnitudes of Th1 and CD8+ [Tc1] *responses* against Listeria antigen were significantly higher in AC-1 treated mice than in PBS treated mice . Regulation TCN1 CD8A 10910289 713965 Here , we compared the capacity of in vitro generated normal liver immature DC and FL-treated donor liver DC to induce alloimmune CD4+ T helper (Th) 1/Th2 and [T cytotoxic (Tc) 1/Tc2] *responses* , in vitro and in vivo . Regulation TCN1 CD8A 12193722 981487 Multiple Chlamydia pneumoniae antigens prime [Tc1] *responses* that inhibit intracellular growth of this vacuolar pathogen . Regulation TCN1 CD8A 14971031 1209298 Dendritic cells generated in the presence of GM-CSF plus IL-15 prime potent [Tc1] *responses* in vivo . Regulation TCN1 CD8A 15557623 1340870 IL-12 p40 levels in serum and magnitudes of CD4+ Th1 and [Tc1] *responses* against Listeria antigen were significantly higher in AC-1 treated mice than in PBS treated mice . Regulation TCN1 CD8A 15843575 1398524 Recently we reported that Cpn infected mice generate an MHC class I-restricted ( + ) [Tc1] *response* against various Cpn Ags , and that CD8 ( + ) CTL to multiple epitopes inhibit Cpn growth in vitro . Regulation TCN1 CD8A 16306600 1486444 Th-cytotoxic T-lymphocyte chimeric epitopes extended by Nepsilon-palmitoyl lysines induce herpes simplex virus type 1-specific effector [Tc1] *responses* and protect against ocular infection . Regulation TCN1 CD8A 16308571 1486536 Here , we show that plasmid DNA vaccination with a cassette encoding antigen ( OVA ) and a second cassette encoding full-length CD40 ligand (CD40L) , a molecule expressed on activated CD4+ T lymphocytes and critical for T cell helper function , can elicit significant titers of antigen-specific immunoglobulins in serum and [Tc1] T cell *responses* in CD4-deficient mice . Regulation TCN1 CD8A 17048270 1641840 Using an adoptive transfer system of OT-I cells expressing OVA ( 257-264 ) /Kb-specific TCR into Tyk2-/- mice followed by challenge with recombinant L. monocytogenes expressing OVA , we found that the defective Tyk2 signaling in the host environment was at least partially responsible for the impaired [T cytotoxic-1 (Tc1)] cell *responses* in Tyk2-/- mice following the infection . Regulation TCN1 CD8A 17274112 1691877 Our data showed that CD4+ Th1 cells with acquired pMHC I by OVA pulsed DC ( DCOVA ) stimulation are capable of prolonging survival and reducing apoptosis formation of active CD8+ Tc1 cells in vitro , and promoting [Tc1] cell tumor localization and memory *responses* in vivo by 3-folds . Regulation TCN1 CD8A 9550413 477786 Identification of Trypanosoma cruzi trans-sialidase family members as targets of protective [TC1] *responses* . Regulation TCN1 CD8B 10910289 713966 Here , we compared the capacity of in vitro generated normal liver immature DC and FL-treated donor liver DC to induce alloimmune CD4+ T helper (Th) 1/Th2 and [T cytotoxic (Tc) 1/Tc2] *responses* , in vitro and in vivo . Regulation TCN1 CD8B 15557623 1340871 IL-12 p40 levels in serum and magnitudes of CD4+ Th1 and [Tc1] *responses* against Listeria antigen were significantly higher in AC-1 treated mice than in PBS treated mice . Regulation TCN1 CD8B 15843575 1398525 Recently we reported that Cpn infected mice generate an MHC class I-restricted ( + ) [Tc1] *response* against various Cpn Ags , and that CD8 ( + ) CTL to multiple epitopes inhibit Cpn growth in vitro . Regulation TCN1 CD8B 16306600 1486445 Th-cytotoxic T-lymphocyte chimeric epitopes extended by Nepsilon-palmitoyl lysines induce herpes simplex virus type 1-specific effector [Tc1] *responses* and protect against ocular infection . Regulation TCN1 CD8B 17274112 1691878 Our data showed that CD4+ Th1 cells with acquired pMHC I by OVA pulsed DC ( DCOVA ) stimulation are capable of prolonging survival and reducing apoptosis formation of active CD8+ Tc1 cells in vitro , and promoting [Tc1] cell tumor localization and memory *responses* in vivo by 3-folds . Regulation TCN1 CD8B 9550413 477787 Identification of Trypanosoma cruzi trans-sialidase family members as targets of protective [TC1] *responses* . Regulation TCN1 CSF2 14971031 1209299 Dendritic cells generated in the presence of plus IL-15 prime potent CD8+ [Tc1] *responses* in vivo . Regulation TCN1 CSF2 2178671 129576 The *effects* of recombinant human granulocyte-macrophage ( rhGM-CSF ) on neutrophil lactoferrin (LF) and [transcobalamin (TC) 1] and 3 secretion were determined in vitro and during in vivo administration in humans . Regulation TCN1 CXCL10 19769732 2140945 Based on our recent studies , efficient CNS tumor homing is a characteristic of cytotoxic T lymphocytes ( CTLs ) with a type 1 phenotype ( Tc1 ) , and this appears to be related to the [Tc1] *response* to the type 1 [ also known as interferon ( IFN ) -inducible protein (IP)-10 ] and expression of an integrin receptor very late antigen (VLA)-4 on Tc1 . Regulation TCN1 IFNG 16531121 1555238 We showed that adenovirus infection had no further effect on the phenotype , the ability to induce producing [Th1/Tc1] *response* or the T cell stimulatory capacity of already mature DCs in vitro . Regulation TCN1 IFNG 17785860 1790834 In contrast to IMP321 , TLR1-9 agonists induce IL-10 and are therefore unable to induce this [Tc1] *response* . Regulation TCN1 IL4 10725199 677497 Our observations demonstrate a negative regulatory *effect* of on memory [Tc1/CD8] ( + ) T cells , but are also consistent with complementary mechanisms important for virus clearance such as virus neutralizing antibodies . Regulation TCN1 IL4 18958887 1982885 Notably , the inhibitory *effects* of on [Tc1] expression of VLA-4 could be blocked by the presence of IL-12 , but not IFN-gamma . Regulation TCN1 NA 2718141 111342 , by contrast , did not significantly *affect* embryonic GSH levels , [TCI] generation , or covalent binding . Regulation TCN1 NELFCD 10910289 713963 Here , we compared the capacity of in vitro generated normal liver immature DC and FL-treated donor liver DC to induce alloimmune CD4+ and CD8+ [T cytotoxic (Tc) 1/Tc2] *responses* , in vitro and in vivo . Regulation TCN1 TRIM26 20087354 2206048 Anti-AFP Th1 response was mainly detected in HCC patients who had normal or mildly elevated serum AFP concentrations ( P=0.00188 ) , whereas there was no significant difference between serum AFP concentrations in these patients and the presence of an [Tc1] *response* . Regulation TCN1 TYK2 17048270 1641839 Using an adoptive transfer system of OT-I cells expressing OVA ( 257-264 ) /Kb-specific TCR into Tyk2-/- mice followed by challenge with recombinant L. monocytogenes expressing OVA , we found that the defective signaling in the host environment was at least partially *responsible* for the impaired CD8+ [T cytotoxic-1 (Tc1)] cell responses in Tyk2-/- mice following the infection . Regulation TDGF1P3 ITGB2 1673986 155031 A direct *role* for phosphorylation in the activation of [CR3] for phagocytosis is consistent with these data . Regulation TDGF1P3 TNF 7684764 219675 The increases in [CR3] and CD14 occurred in parallel and were *independent* of protein synthesis and production . Regulation TEAD4 TNF 24213609 2897243 Both hypoxia and inflammatory factor regulate gene expression of HIF-1a , but how [RTEF-1] and TNF-a coordinately *regulate* HIF-1a gene transcription is unclear . Regulation TEC EPHB2 21243004 2499661 The DP [thymocyte-TEC] conjugate formation was also *affected* by the absence of receptors . Regulation TEC TNF 18480171 1933391 Indoleamine 2,3-dioxygenase (IDO) catabolizes tryptophan to N-formyl kynurenine and has a proapoptotic role in renal [tubular epithelial cells (TEC)] in *response* to IFN-gamma and in vitro . Regulation TECR IL1B 19171646 2027686 The NF-kappaB inhibitor curcumin blocked the *effects* of on both [TER] and the subcellular localization of ZO-1 and occludin . Regulation TECR TNF 18235000 1864350 The NF-kappaB inhibitor curcumin blocked the *effects* of on [TER] and the subcellular localization of ZO-1 at late phase . Regulation TENM1 OLFM4 24739570 2936318 Cell based binding experiments with mutant proteins revealed that the Olfactomedin domain was required for binding to FLRT3 , whereas both the and Lectin domains were *involved* in binding to [Teneurin 1] . Regulation TERT IFI27 14612944 1163384 In this study , using the recombinant adenoviral vector expressing p27KIP1 ( Adp27KIP1 ) , we investigated whether *affects* [telomerase] activity in malignant glioma U373-MG cells . Regulation TET1 TNFSF10 22530952 2631079 The expression of soluble could be strictly *controlled* by the [Tet-On] system in both normal and cancer cells . Regulation TET2 TNFSF10 22530952 2631077 The expression of soluble could be strictly *controlled* by the [Tet-On] system in both normal and cancer cells . Regulation TET3 TNFSF10 22530952 2631078 The expression of soluble could be strictly *controlled* by the [Tet-On] system in both normal and cancer cells . Regulation TF ACO1 17127713 1716709 coordinately *controls* the expression of [transferrin receptor 1 (TfR1)] and ferritin by binding to iron-responsive elements ( IREs ) within their mRNAs . Regulation TF ALB 7077127 20863 In contrast , neither rabbit granule lysozyme nor human [transferrin] induces neutropenia in the rabbit nor does transferrin or bovine *affect* the adherent properties in vivo of the phagocytic cells of the hamster . Regulation TF CFP 2646374 108714 RIIIS/J mice treated with LPS produce a low anti-bromelain treated mouse RBC splenic plaque forming cell response and a normal anti-mouse [transferrin] splenic *response* . Regulation TF CRP 12296612 990963 In the present study , the *effects* of and ferritin on serum albumin , [transferrin] and haemoglobin ( Hb ) were assessed to investigate the relationship between inflammation , hypoalbuminaemia and anaemia in haemodialysis patients . Regulation TF CSF2 15210846 1281512 Macrophage differentially *regulates* low density lipoprotein and [transferrin] receptors . Regulation TF DDIT3 12939601 1133267 Transcriptional *regulation* of the human [transferrin] gene by in hepatoma cells . Regulation TF EBF3 8297471 240916 The specific *response* of the [transferrin] gene to was not found in the liver or in the uterus . Regulation TF EBF3 8297471 240922 We have detected for the first time an induction of [transferrin] gene expression in the mammary gland in *response* to , and these results support the view that the pattern of transferrin gene multi modulated expression is tissue- and species-specific . Regulation TF EGF 1797590 176871 In the first demonstration of a highly polarised response of Sertoli cells to hormonal stimuli , the *effects* of insulin , FSH and on vectorial [transferrin] secretion were effected primarily via the basal membrane of the Sertoli cell and operated independent of mechanisms controlling total transferrin secretion . Regulation TF EGF 8021875 263093 The ratio of polarized [transferrin] secretion in *response* to FSH , , or in combination was also examined . Regulation TF FGF2 2125283 146723 The acute and chronic *effects* of on [transferrin (TF)] secretion from Sertoli cells were investigated by using reverse hemolytic plaque assays which enabled the visualization of release from individual cells in culture . Regulation TF GCG 6877237 29751 This hormone also enhanced [transferrin] production and *response* . Regulation TF HFE 12547236 1028819 Time resolved measurements of cell membrane capacitance provide a new methodological approach to study the endocytic uptake of [transferrin] and its *regulation* by , the hereditary hemochromatosis protein . Regulation TF HFE 15173932 1254260 *affects* the interaction of [transferrin] bound iron with transferrin receptors (TfR) thereby modulating iron uptake . Regulation TF HGF 8675150 365723 The *effects* of on the synthesis of albumin , [transferrin] , fibronectin , alpha1-antichymotrypsin , and haptoglobin could be counteracted by the simultaneous presence of IL-6 in the incubation media . Regulation TF HRES1 18432409 1900177 HRES-1/p28 is a nuclear autoantigen recognized by cross-reactive antiviral antibodies , while *regulates* surface expression of CD4 and the [transferrin receptor (TFR)] through endosome recycling . Regulation TF HTR2C 2164094 136125 5-HT induced [transferrin] production by choroid plexus epithelial cells in culture : *role* of <5-HT1c> receptor . Regulation TF IFNG 3134021 94305 did not *affect* [transferrin] binding to Daudi cells or phytohemagglutinin stimulated human lymphocytes , neither of which respond to its antigrowth action . Regulation TF IL1A 11900596 921703 Our results may suggest the *involvement* of testicular paracrine/autocrine factors ( ) and endocrine ( FSH ) factors in the regulation of [transferrin] secretion by SC . Regulation TF IL1B 16123165 1482258 In testicular Sertoli cells , *regulates* steroid , lactate , and [transferrin] secretion ; Regulation TF IL1B 8406676 233050 *Effects* of and tumor necrosis factor-alpha on the expression of glial fibrillary acidic protein and [transferrin] in cultured astrocytes . Regulation TF IL2 1905226 161546 *Effects* of interleukin-6 , , and tumor necrosis factor alpha on [transferrin] release from Sertoli cells in culture . Regulation TF IL2 1905226 161548 In an attempt to determine whether these agents may influence other types of secreted substances , we used plaque assays to measure the *effect* of interleukin-6 (IL-6) , , and tumor necrosis factor alpha on [transferrin (TF)] release from Sertoli cells in culture . Regulation TF IL6 1905226 161547 *Effects* of , interleukin-2 , and tumor necrosis factor alpha on [transferrin] release from Sertoli cells in culture . Regulation TF IL6 1905226 161549 In an attempt to determine whether these agents may influence other types of secreted substances , we used plaque assays to measure the *effect* of , interleukin-2 (IL-2) , and tumor necrosis factor alpha on [transferrin (TF)] release from Sertoli cells in culture . Regulation TF INHBA 2189403 133683 The *effects* of on the levels of zeta-globin and several proto-oncogene mRNAs and [transferrin receptors (Tf-R)] of K-562 cells were examined . Regulation TF INHBA 8033824 264141 Because of the secretion of activin-A by peritubular myoid cells , the *effects* of recombinant on Sertoli cell inhibin and [transferrin] secretion were examined . Regulation TF INS 1797590 176869 IGF-I and IGF-II were effective at physiological concentrations ( ED50 = 1 ng/ml ) in lowering transferrin ratio and were 100-fold more potent than insulin suggesting that *effects* on vectorial [transferrin] secretion by Sertoli cells is mediated through type 1 IGF receptors . Regulation TF INS 3788717 66305 Experiments done with cultured Sertoli cells suggest that the [transferrin] mRNA levels are *regulated* by FSH , , vitamin A , and testosterone . Regulation TF INS 7031664 18452 Synthesis of [transferrin] and a few other plasma proteins was not *affected* by the presence of . Regulation TF MBP 23086799 2768990 For example , apart from inhibiting proteinases , it *regulates* binding of [transferrin] to its surface receptor , binds defensin and , etc. , binds several important cytokines , including basic fibroblast growth factor (bFGF) , platelet derived growth factor ( PDGF ) , nerve growth factor (NGF) , interleukin-1ß (IL-1ß) , and interleukin-6 (IL-6) , and modify their biological activity . Regulation TF PACSIN2 15371016 1297414 Opposing *roles* of GS32 and in regulating the surface level of [transferrin receptor (TfR)] were observed . Regulation TF QRICH1 24561970 2919316 Our aim was to compare the *effects* of intravenous , enteral , and enteral plus intravenous supplemented on plasma [transferrin] , nitrogen balance , and creatinine/height index in septic patients with malnutrition . Regulation TF QRICH2 24561970 2919317 Our aim was to compare the *effects* of intravenous , enteral , and enteral plus intravenous supplemented on plasma [transferrin] , nitrogen balance , and creatinine/height index in septic patients with malnutrition . Regulation TF RAB4A 18432409 1900178 HRES-1/p28 is a nuclear autoantigen recognized by cross-reactive antiviral antibodies , while *regulates* surface expression of CD4 and the [transferrin receptor (TFR)] through endosome recycling . Regulation TF SETD2 10518614 652436 We investigated whether is *involved* in transcriptional activation of the [transferrin receptor (TfR)] , a membrane protein which mediates cellular iron uptake , in response to iron deprivation . Regulation TF SOD1 9324399 446658 The *effect* of and selenium on the blood level of ferritin and [transferrin] in patients with hemoblastosis was studied . Regulation TF SOD2 9324399 446659 The *effect* of and selenium on the blood level of ferritin and [transferrin] in patients with hemoblastosis was studied . Regulation TF SOD3 9324399 446660 The *effect* of and selenium on the blood level of ferritin and [transferrin] in patients with hemoblastosis was studied . Regulation TF STX10 16154903 1455469 On the other hand , reciprocally co-immunoprecipitated endosomal syntaxin 12/13 , and knockdown of syntaxin 10 expressions *affects* the surface expression of [transferrin receptor (TfR)] and seems to induce the formation of an immobile TfR pool . Regulation TF TFRC 10730863 478651 expression is *controlled* differently by [transferrin] bound and non-transferrin iron in human cells . Regulation TF TGFB1 2725526 113337 had no *effect* on [transferrin] production nor the ability of hormones to influence transferrin production . Regulation TF TNF 8406676 233049 *Effects* of interleukin-1 beta and on the expression of glial fibrillary acidic protein and [transferrin] in cultured astrocytes . Regulation TF TRH 6819989 25423 These *effects* of appeared both in the medium containing a higher concentration of serum and in that containing six growth factors , i.e . insulin , [transferrin] , parathyroid hormone , fibroblast growth factor , triiodothyronine , and multiplication stimulating activity ( MSA ) instead of serum . Regulation TF TYRP1 2262806 146498 The *effect* of severe deficiency on serum TTR , as well as on albumin and [transferrin] levels , was studied in growing rats for 8 d . Regulation TFAP2A KLF9 9858544 581957 Transcriptional *regulation* of the [AP-2alpha] promoter by and AP-2rep , a novel wt-1/egr related zinc finger repressor . Regulation TFAP2A TNF 11438643 833042 We tested this hypothesis by examining the *effects* of on the expression of [AP-2] in breast cancer cells . Regulation TFAP2A ZIC2 21932309 2479866 We found that lamprey neural plate border expression of prdm1 is activated by [Ap-2] and Msx , but is *independent* of Pax3/7 and . Regulation TFAP4 MAP2K6 16624952 1551797 Moreover , [L-AP-4] decreased colchicine toxicity on TH+ neurons in an *dependent* manner as well . Regulation TFDP1 AXIN2 22773187 2639618 [DP1] negatively *regulates* Wnt/ß-catenin signalling by inhibiting interaction and by enhancing poly-ubiquitination of ß-catenin . Regulation TFF1 TNF 17565651 1753556 The aim of this study was to investigate the *effect* of , a representative proinflammatory cytokine , on [TFF1] expression . Regulation TFPI ARSA 17259075 1691228 We assessed the *effect* of on the myocardial production of [15-epi-LXA4] and PGI ( 2 ) after induction by lipopolysaccharide (LPS) or PIO+ATV . Regulation TFPI ARSA 17259075 1691231 or PIO+ATV+1400 W . alone had no *effect* on myocardial [15-epi-LXA4] . Regulation TFPI F3 17196206 1821754 is a key mediator of atherosclerotic plaque thrombogenicity and may be *regulated* by plaque [TF pathway inhibitor (TFPI)] . Regulation TFPI MMP28 21849050 2477493 Downregulation of [TFPI] also stimulated migration and invasion of cells , and elevated activity was *involved* in the increased invasion observed . Regulation TFPI MMP7 21849050 2477508 Downregulation of [TFPI] also stimulated migration and invasion of cells , and elevated activity was *involved* in the increased invasion observed . Regulation TFPI TFPI2 17023682 1641539 The purpose of this study is to investigate the expression and regulation of type-2 [tissue factor pathway inhibitor] ( TFPI-2 ) in endothelial cells , as well as the *regulation* of human endothelial cell ( EC ) function by . Regulation TFPI TNF 19169266 2038751 This study further investigated the impact of testosterone on [TFPI] levels in *response* to inflammatory cytokine . Regulation TFPI2 CA2 20045670 2218286 When phosphatases such as *dependent* protein kinase phosphatase ( CaMKP ) , protein phosphatase 2C ( PP2C ) , protein [phosphatase 5 (PP5)] , and alkaline phosphatase were resolved by polyacrylamide gel electrophoresis in the absence of SDS and the gel was incubated with a fluorogenic substrate such as 4-methylumbelliferyl phosphate ( MUP ) , all of these phosphatase activities could be detected in situ . Regulation TFPI2 CALM3 20045670 2218287 When phosphatases such as *dependent* protein kinase phosphatase ( CaMKP ) , protein phosphatase 2C ( PP2C ) , protein [phosphatase 5 (PP5)] , and alkaline phosphatase were resolved by polyacrylamide gel electrophoresis in the absence of SDS and the gel was incubated with a fluorogenic substrate such as 4-methylumbelliferyl phosphate ( MUP ) , all of these phosphatase activities could be detected in situ . Regulation TFPI2 HPSE 20031192 2241231 These results indicate a regulatory *effect* of on TFPI and [TFPI-2] in trophoblasts , suggesting a potential involvement of heparanase in early miscarriages . Regulation TFPI2 MED1 14983234 1214640 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED10 14983234 1214635 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED11 14983234 1214638 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED13 14983234 1214622 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED13L 14983234 1214623 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED14 14983234 1214627 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED15 14983234 1214616 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED16 14983234 1214618 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED17 14983234 1214629 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED18 14983234 1214634 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED19 14983234 1214637 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED20 14983234 1214617 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED21 14983234 1214614 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED22 14983234 1214615 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED23 14983234 1214628 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED24 14983234 1214624 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED25 14983234 1214636 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED26 14983234 1214630 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED27 14983234 1214631 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED29 14983234 1214626 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED30 14983234 1214625 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED31 14983234 1214633 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED4 14983234 1214619 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED6 14983234 1214620 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED7 14983234 1214632 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 MED8 14983234 1214621 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 OPA1 14983234 1214639 Moreover , the LPS response was abolished in mice with a hepatocyte-specific KO for the gp130 receptor , thus indicating that a from hepatocytes is *involved* in the up-regulation of [TFPI-2] in non-parenchymal cells . Regulation TFPI2 PPP5C 11945080 930056 Subcellular localization of [PP5/TFPI-2] in human placenta : a possible *role* of as an anti-coagulant on the surface of syncytiotrophoblasts . Regulation TFPI2 PPT1 18922470 1977215 We show that Cdc37 and [PP5/Ppt1] associate in Hsp90 complexes in yeast and in human tumor cells , and that *regulates* phosphorylation of Ser13-Cdc37 in vivo , directly affecting activation of protein kinase clients by Hsp90-Cdc37 . Regulation TFPI2 PRM1 7225294 15170 The *effect* of on serum levels of [placental protein 5 (PP5)] in normal and abnormal pregnancy : a possible relation to coagulation abnormalities . Regulation TFPI2 PRM2 7225294 15171 The *effect* of on serum levels of [placental protein 5 (PP5)] in normal and abnormal pregnancy : a possible relation to coagulation abnormalities . Regulation TFPI2 PRM3 7225294 15169 The *effect* of on serum levels of [placental protein 5 (PP5)] in normal and abnormal pregnancy : a possible relation to coagulation abnormalities . Regulation TFR2 TF 19828835 2164812 TFR1 levels are regulated by cellular iron levels while [TFR2] levels are *regulated* by saturation . Regulation TFR2 TNF 16221503 1517859 *regulates* the mRNA levels of HAMP , IREG1 , DMT1 and [TfR2] in cultured hepatocytes from both iron loaded and control animals . Regulation TFRC EPHB2 24552586 2919204 Induction of by aripiprazole did not *affect* [p90RSK] signaling but quetiapine decreased RSK phosphorylation within 1-hour of administration . Regulation TFRC IL1B 1696948 139411 Neither [transferrin receptor] mRNA levels nor the number of receptors displayed on the cell surface was *affected* by . Regulation TFRC MAP2K6 15299023 1303227 This mechanism appears to involve type I PKA dependent phosphorylation of CBP and inhibition of *dependent* phosphorylation of [p90RSK] . Regulation TFRC TF 10730863 478652 [Transferrin receptor] expression is *controlled* differently by bound and non-transferrin iron in human cells . Regulation TFRC TF 10762570 683739 The monocytes failed to up-regulate [transferrin receptor] expression appropriately in *response* to . Regulation TFRC TF 10762570 683741 Thus , a nonpermissive state for L. pneumophila intracellular multiplication is associated with low levels of transferrin receptor expression in nonactivated monocytes and with an inability to up-regulate [transferrin receptor] expression in *response* to . Regulation TFRC TF 3465751 65960 Because gallium has therapeutic potential , the *effects* of on leukemic cell proliferation , [transferrin receptor] expression , and cellular iron utilization were studied . Regulation TFRC TF 8379943 230135 Since cellular TfR expression is tightly regulated by the availability of iron , we investigated the *effects* of on [TfR] mRNA levels in myeloid HL60 and lymphoid CCRF-CEM cells . Regulation TFRC TF 8450071 214126 We have also explored the *effect* of iron on [transferrin receptor] expression and intracellular ferritin content in human monocytes . Regulation TFRC TNF 2016326 156937 and interleukin 1-alpha *regulate* [transferrin receptor] in human diploid fibroblasts . Regulation TFRC TNF 2016326 156941 We have studied [transferrin receptor] expression in MRC5 human fibroblasts in *response* to ( TNF , cachectin ) or interleukin 1-alpha (IL-1) . Regulation TG TNF 7867596 296465 In the present study , we used FRTL5 cells , a cultured rat thyroid follicular cell line , to examine the *effects* of IFN-gamma and on type I 5'-deiodinase ( 5'D-I ) activity and 5'D-I , thyroid peroxidase (TPO) and [thyroglobulin (Tg)] gene expression . Regulation TGFA TNF 10623834 658416 *regulates* [transforming growth factor-alpha] expression in regenerating murine liver and isolated hepatocytes . Regulation TGFB1 CST6 17429295 1724093 Therefore , the *role* of in the pathogenesis of coronary artery ectasia and its potential interaction with [transforming growth factor-beta1] should be evaluated in further studies . Regulation TGFB1 CTGF 14635403 1171124 We therefore immunochemically investigated the pathogenesis of paraneoplastic syndrome and found that might be involved and [transforming growth factor-beta] ( TGF-beta ) might not be *involved* in this case . Regulation TGFB1 CTGF 15037576 1224041 *Involvement* of in [TGF-beta1-stimulation] of myofibroblast differentiation and collagen matrix contraction in the presence of mechanical stress . Regulation TGFB1 EPHB2 10406835 629635 Thus , we show that , through AP-1 activation , is *involved* in Ang II-induced [TGF-beta(1)] mRNA expression in VSMCs and suggest that ERK may participate in vascular remodeling of hypertension . Regulation TGFB1 EPHB2 11095645 755347 The conclusion is that activation of in mesangial cells is *responsible* for high-glucose induced stimulation of [TGF-beta1] and contributes to the increased extracellular matrix expression . Regulation TGFB1 EPHB2 12677169 1076927 We demonstrate , for the first time , that glycated albumin activates RAW cell ERK and promotes *dependent* increases in [TGF-beta(1)] production , oxidative stress , and NF-kappa B activation . Regulation TGFB1 EPHB2 16972260 1627988 Taken together our results demonstrate that Hcy mediated [TGF-beta1] upregulation triggers endothelial-myofibroblast differentiation secondary to FAK phosphorylation and that Hcy induced activation is *involved* in ECM remodeling by altering collagen type-1 homeostasis . Regulation TGFB1 EPHB2 23680829 2819340 Gene expression of ADAMTS-4 , ADAMTS-5 , and [TGF-b] were not *affected* by IL-1 or inhibition . Regulation TGFB1 IL1B 16253647 1471883 The question of whether tumor necrosis factor alpha (TNF-alpha) and/or *regulate* the release of [TGF-beta1] was investigated by incubation of adipose tissue explants with a soluble human TNF-alpha receptor ( etanercept ) and a neutralizing antihuman IL-1 beta antibody . Regulation TGFB1 IL1B 16805677 1579600 *Effect* of on [transforming growth factor-beta] and bone morphogenetic protein-2 expression in human periodontal ligament and alveolar bone cells in culture : modulation by avocado and soybean unsaponifiables . Regulation TGFB1 IL1B 17426628 1723995 Expression of TIMP-3 mRNA in NP was upregulated by [TGF-beta1] but was not *affected* by . Regulation TGFB1 IL1B 19420104 2120145 *regulates* proximal tubular cell [transforming growth factor beta-1] signalling . Regulation TGFB1 IL1B 2009947 154931 Neither nor IL-6 had an observable *effect* on [TGF beta 1] mRNA expression . Regulation TGFB1 MAP2K6 10511312 651225 Ras- and *dependent* and -independent pathways in p21Cip1/Waf1 induction by fibroblast growth factor-2 , platelet derived growth factor , and [transforming growth factor-beta1] . Regulation TGFB1 MAP2K6 19494553 2098063 [TGFbeta1] increased cellular and secreted CTGF protein in HKC cells in a *dependent* manner . Regulation TGFB1 MMP28 18996114 2015974 Inhibition of MMP activity restored TGF-beta1 levels , suggesting an *involvement* of activities in the down-regulation of [TGF-beta1] by tamoxifen . Regulation TGFB1 MMP7 18996114 2015989 Inhibition of MMP activity restored TGF-beta1 levels , suggesting an *involvement* of activities in the down-regulation of [TGF-beta1] by tamoxifen . Regulation TGFB1 PLAT 9875232 557170 Plasmin , substilisin-like endoproteases , , and urokinase plasminogen activator are *involved* in activation of latent [TGF-beta 1] in human seminal plasma . Regulation TGFB1 PLAU 8126064 251293 The *role* of receptor bound ( uPA ) in cellular activation of latent [transforming growth factor-beta] ( LTGF-beta ) was investigated in a model system of mouse LB6 cells transfected with either a human uPA receptor cDNA ( LhuPAR+ ) , a human prouPA cDNA ( LhuPA ) , or a control neomycin-resistance cDNA ( Lneo ) . Regulation TGFB1 PLAU 9875232 557171 Plasmin , substilisin-like endoproteases , tissue plasminogen activator , and are *involved* in activation of latent [TGF-beta 1] in human seminal plasma . Regulation TGFB1 RGS2 12225869 987858 Among the novel genes , the mRNA levels for the high mobility group protein 1 (hmg-1) , the ( rgs-2 ) , the [transforming growth factor beta] inducible early growth *response* ( tieg ) , the inhibitor of DNA binding 3 (id3) , and the heterogeneous nuclear ribonucleoprotein H ( hnrnp h ) were changed following injury . Regulation TGFB1 STK39 16251192 1489776 *Regulation* of [transforming growth factor-beta] signaling and PDK1 kinase activity by physical interaction between PDK1 and receptor associated protein . Regulation TGFB1 SYNM 18637143 1960105 The upregulated hepatic protein expression of [transforming growth factor-beta] ( TGF-beta ) in *response* to was markedly attenuated by HGF gene transfer accompanied by the increased protein expression for matrix metalloproteinases (MMP)-3 and -13 . Regulation TGFB1 TGM2 10926856 719208 This small effect was not specific for TSP-1 : matrix metalloproteinase 2 , tissue inhibitor of matrix metalloproteinase 2 and active plasminogen activator inhibitor 1 , but not , human serum albumin or immunoglobulin , had quantitatively similar *effects* on latent [TGF-beta1] . Regulation TGFB1 TGM2 10943862 721458 *Participation* of in the activation of latent [transforming growth factor beta1] in aging articular cartilage . Regulation TGFB1 TGM2 7896898 300003 The activation of latent [transforming growth factor-beta] ( TGF-beta ) by vascular endothelial cells ( ECs ) is *regulated* by cellular plasminogen activator (PA)/plasmin , , and latent TGF-beta levels . Regulation TGFB1 TNF 12524413 1047913 MMP2 secretion by PSCs was significantly increased by [TGF-beta1] and IL-6 , but was not *affected* by . Regulation TGFB1 TNF 15361231 1293644 IFN-gamma and play a role in both protective immunity and the pathology of the infection , and the inflammatory disease may be *regulated* by IL-10 and [transforming growth factor-beta] . Regulation TGFB1 TNF 15553672 1338688 Two out of 6 pts who experienced stable disease after the treatment had high IFN-gamma and responses and no [TGF-beta1] or IL-4 *response* . Regulation TGFB1 TNF 16249231 1553519 The immunohistological findings of a limited sample suggest a *role* for BM in sacroiliitis , for and IL6 in early , active lesions , and for [TGFbeta1] at the time of secondary cartilage and bone proliferation . Regulation TGFB1 TNF 16253647 1471882 The question of whether and/or interleukin 1 beta (IL-1 beta) *regulate* the release of [TGF-beta1] was investigated by incubation of adipose tissue explants with a soluble human TNF-alpha receptor ( etanercept ) and a neutralizing antihuman IL-1 beta antibody . Regulation TGFB1 TNF 19317165 2007715 To investigate the relationship of and transforming growth factor beta1 ( TGF-beta1 ) with the occurrence of ankylosing spondylitis (AS) , and the *effects* of Bushen Tongdu Decoction (BTD) on serum TNF-alpha and [TGF-beta1] , levels in patients . Regulation TGFB1 TNF 20141610 2178967 In the current study , we further investigated the molecular mechanisms involved in *regulation* of [TGF-beta(1)] expression . Regulation TGFB1 TNF 7540643 310128 The *effect* of was variable , and anti [transforming growth factor-beta] had no effect on the number of CFU-GM in HIV infected LTC . Regulation TGFB1 TNF 8457602 215621 Interleukin-1 binding and prostaglandin E2 synthesis by amnion cells in culture : *regulation* by , [transforming growth factor-beta] , and interleukin-1 receptor antagonist . Regulation TGFB1 TNF 8623935 354867 Neither nor interferon (IFN)-gamma ( both 10 ng/ml ) *affected* [TGF-beta 1] or TGF-beta 2 synthesis by HPMCs . Regulation TGFB1 TNF 9816237 408365 We studied the *effect* of on [transforming growth factor beta] ( TGF-beta ) secretion by human breast cell lines to further characterize the antitumor effects of TNF-alpha . Regulation TGFB2 CTGF 14635403 1171125 We therefore immunochemically investigated the pathogenesis of paraneoplastic syndrome and found that might be involved and [transforming growth factor-beta] ( TGF-beta ) might not be *involved* in this case . Regulation TGFB2 CTGF 17192487 1680331 In the current study , we first demonstrated the correlation between the concentrations of [TGF-beta2] as well as CTGF in the vitreous and gene *regulation* in cultured hyalocytes . Regulation TGFB2 IL1B 16805677 1579601 *Effect* of on [transforming growth factor-beta] and bone morphogenetic protein-2 expression in human periodontal ligament and alveolar bone cells in culture : modulation by avocado and soybean unsaponifiables . Regulation TGFB2 PLAU 8126064 251294 The *role* of receptor bound ( uPA ) in cellular activation of latent [transforming growth factor-beta] ( LTGF-beta ) was investigated in a model system of mouse LB6 cells transfected with either a human uPA receptor cDNA ( LhuPAR+ ) , a human prouPA cDNA ( LhuPA ) , or a control neomycin-resistance cDNA ( Lneo ) . Regulation TGFB2 RGS2 12225869 987861 Among the novel genes , the mRNA levels for the high mobility group protein 1 (hmg-1) , the ( rgs-2 ) , the [transforming growth factor beta] inducible early growth *response* ( tieg ) , the inhibitor of DNA binding 3 (id3) , and the heterogeneous nuclear ribonucleoprotein H ( hnrnp h ) were changed following injury . Regulation TGFB2 STK39 16251192 1489792 *Regulation* of [transforming growth factor-beta] signaling and PDK1 kinase activity by physical interaction between PDK1 and receptor associated protein . Regulation TGFB2 SYNM 18637143 1960106 The upregulated hepatic protein expression of [transforming growth factor-beta] ( TGF-beta ) in *response* to was markedly attenuated by HGF gene transfer accompanied by the increased protein expression for matrix metalloproteinases (MMP)-3 and -13 . Regulation TGFB2 TGM2 7896898 300011 The activation of latent [transforming growth factor-beta] ( TGF-beta ) by vascular endothelial cells ( ECs ) is *regulated* by cellular plasminogen activator (PA)/plasmin , , and latent TGF-beta levels . Regulation TGFB2 TNF 15361231 1293646 IFN-gamma and play a role in both protective immunity and the pathology of the infection , and the inflammatory disease may be *regulated* by IL-10 and [transforming growth factor-beta] . Regulation TGFB2 TNF 7540643 310129 The *effect* of was variable , and anti [transforming growth factor-beta] had no effect on the number of CFU-GM in HIV infected LTC . Regulation TGFB2 TNF 8457602 215622 Interleukin-1 binding and prostaglandin E2 synthesis by amnion cells in culture : *regulation* by , [transforming growth factor-beta] , and interleukin-1 receptor antagonist . Regulation TGFB2 TNF 8623935 354869 Neither nor interferon (IFN)-gamma ( both 10 ng/ml ) *affected* TGF-beta 1 or [TGF-beta 2] synthesis by HPMCs . Regulation TGFB2 TNF 9816237 408366 We studied the *effect* of on [transforming growth factor beta] ( TGF-beta ) secretion by human breast cell lines to further characterize the antitumor effects of TNF-alpha . Regulation TGFB3 CTGF 14635403 1171126 We therefore immunochemically investigated the pathogenesis of paraneoplastic syndrome and found that might be involved and [transforming growth factor-beta] ( TGF-beta ) might not be *involved* in this case . Regulation TGFB3 IL1B 16805677 1579602 *Effect* of on [transforming growth factor-beta] and bone morphogenetic protein-2 expression in human periodontal ligament and alveolar bone cells in culture : modulation by avocado and soybean unsaponifiables . Regulation TGFB3 PLAU 8126064 251295 The *role* of receptor bound ( uPA ) in cellular activation of latent [transforming growth factor-beta] ( LTGF-beta ) was investigated in a model system of mouse LB6 cells transfected with either a human uPA receptor cDNA ( LhuPAR+ ) , a human prouPA cDNA ( LhuPA ) , or a control neomycin-resistance cDNA ( Lneo ) . Regulation TGFB3 RGS2 12225869 987864 Among the novel genes , the mRNA levels for the high mobility group protein 1 (hmg-1) , the ( rgs-2 ) , the [transforming growth factor beta] inducible early growth *response* ( tieg ) , the inhibitor of DNA binding 3 (id3) , and the heterogeneous nuclear ribonucleoprotein H ( hnrnp h ) were changed following injury . Regulation TGFB3 STK39 16251192 1489808 *Regulation* of [transforming growth factor-beta] signaling and PDK1 kinase activity by physical interaction between PDK1 and receptor associated protein . Regulation TGFB3 SYNM 18637143 1960107 The upregulated hepatic protein expression of [transforming growth factor-beta] ( TGF-beta ) in *response* to was markedly attenuated by HGF gene transfer accompanied by the increased protein expression for matrix metalloproteinases (MMP)-3 and -13 . Regulation TGFB3 TGM2 7896898 300019 The activation of latent [transforming growth factor-beta] ( TGF-beta ) by vascular endothelial cells ( ECs ) is *regulated* by cellular plasminogen activator (PA)/plasmin , , and latent TGF-beta levels . Regulation TGFB3 TNF 15361231 1293648 IFN-gamma and play a role in both protective immunity and the pathology of the infection , and the inflammatory disease may be *regulated* by IL-10 and [transforming growth factor-beta] . Regulation TGFB3 TNF 7540643 310130 The *effect* of was variable , and anti [transforming growth factor-beta] had no effect on the number of CFU-GM in HIV infected LTC . Regulation TGFB3 TNF 8457602 215623 Interleukin-1 binding and prostaglandin E2 synthesis by amnion cells in culture : *regulation* by , [transforming growth factor-beta] , and interleukin-1 receptor antagonist . Regulation TGFB3 TNF 9816237 408367 We studied the *effect* of on [transforming growth factor beta] ( TGF-beta ) secretion by human breast cell lines to further characterize the antitumor effects of TNF-alpha . Regulation TGFBR1 CCND1 10471535 641899 Our findings suggest that in some cell types cyclin D1 expression may be important for TGF-beta1 mediated signaling and that may be *involved* in the transcriptional regulation of [TbetaRI] . Regulation TGM1 CAPN8 12859959 1111055 Also , the absence of or any detectable cysteine protease did not *affect* the [transglutaminase] activity in the erythrocyte lysate . Regulation TGM1 TNF 1675987 160956 had little *effect* on cornified envelope formation and [transglutaminase] activity in the preconfluent cells . Regulation TGM2 ADO 15279680 1282857 <8-Cl-Ado> did not *affect* 1,25 ( OH ) 2D3 stimulated keratin 1 protein expression or [transglutaminase] activity . Regulation TGM2 AKT1 21525012 2439799 We further determined JNK and ERK , but not and NF-?B , are *responsible* for EGFR mediated [TGM2] expression . Regulation TGM2 AKT2 21525012 2439800 We further determined JNK and ERK , but not and NF-?B , are *responsible* for EGFR mediated [TGM2] expression . Regulation TGM2 AKT3 21525012 2439801 We further determined JNK and ERK , but not and NF-?B , are *responsible* for EGFR mediated [TGM2] expression . Regulation TGM2 BMP4 9582307 503890 The TGF-beta1 , BMP2 , and *regulation* of the [transglutaminase] promoter activity was similar to the responses we observed for the endogenous transglutaminase activity of Mv1Lu and MC3T3 E1 cells . Regulation TGM2 BMP4 9582307 503900 The results of these experiments suggest that TGF-beta1 , BMP2 , and *regulation* of mouse [tissue transglutaminase] gene expression requires a composite TRE located in the 5'-flanking DNA . Regulation TGM2 CA2 11853093 913339 Tissue transglutaminase (tTG) catalyzes a *dependent* [transglutaminase (TGase)] activity which cross-links proteins and stabilizes many tissues [ C.S. Greenberg et al. FASEB J. 5 ( 1991 ) 3071 ] . Regulation TGM2 CA2 16153866 1467420 The shrimp CP was able to form stable clots in vitro in the presence of hemocyte lysate and Ca2+ , suggesting that the clotting reaction is catalyzed by a *dependent* [transglutaminase] present in shrimp hemocytes . Regulation TGM2 CA2 16212941 1468671 *Regulation* of [tissue transglutaminase] by prolonged increase of intracellular , but not by initial peak of transient Ca2+ increase . Regulation TGM2 CA2 1679061 164808 These findings suggest that pentoxifylline can reduce shear induced periodic Ca2+ entry that leads to transient activation of *dependent* [transglutaminase] , accumulation of crosslinked proteins , and loss of erythrocyte deformability . Regulation TGM2 CA2 2565076 110711 An examination of the *effect* of on [transglutaminase] , a cytosolic enzyme in the erythrocyte which cross-links membrane proteins and renders cells less deformable , demonstrated a correlation between enzyme activity and Ca2+ induced hemolysis . Regulation TGM2 CA2 2572221 119374 Bovine aortic endothelial cells contain *dependent* tissue-type [transglutaminase] . Regulation TGM2 CA2 2572608 120857 Effects of pentoxifylline on *dependent* [transglutaminase] in rat erythrocytes . Regulation TGM2 CA2 2572608 120878 45Ca2+ uptake , activation of *dependent* [transglutaminase] , and products of the crosslinking reaction were measured . Regulation TGM2 CA2 2572608 120899 Pentoxifylline , a drug that promotes erythrocyte deformability , diminished Ca2+ entry and inhibited activation of *dependent* [transglutaminase] , and had a prophylactic role on the effects of Ca2+ entry due to shear . Regulation TGM2 CA2 6114753 15782 The cross linking processes bringing about the observed increase in polymer formation are thus the result of a *dependent* platelet [transglutaminase] activity . Regulation TGM2 CA2 6136967 25702 Brain [transglutaminase] is *dependent* , has an electrophoretic mobility similar to that of erythrocyte transglutaminase , and is active in human postmortem brain from aged normal individuals and patients with Alzheimer disease ( senile dementia ) . Regulation TGM2 CA2 6147286 40111 Pancreatic islet homogenates display *dependent* [transglutaminase] activity . Regulation TGM2 CA2 6150482 43158 A *dependent* [transglutaminase] ( EC 2.3.2.13 ) has been demonstrated in the eye lenses of several mammalian species [ Lorand , L. , Hsu , L. K. M. , Siefring , G. E. , Jr. , & Rafferty , N. S. ( 1981 ) Proc. Natl . Acad . Regulation TGM2 CA2 8611158 352945 Measurement of [tissue transglutaminase] activity in a permeabilized cell system : its *regulation* by and nucleotides . Regulation TGM2 CA2 9778408 540382 On account of its protein crosslinking activity , the *dependent* [transglutaminase] of the lens is likely to be involved in the formation of cataracts . Regulation TGM2 CALM3 14985437 1214842 *regulates* [transglutaminase 2] cross linking of huntingtin . Regulation TGM2 CALM3 14985437 1214852 Because *regulates* [transglutaminase] activity in erythrocytes , platelets , and the gizzard , we hypothesized that calmodulin increases cross linking of huntingtin in the HD brain . Regulation TGM2 CALM3 2866189 53917 Catalytic properties of a *regulated* [transglutaminase] from human platelet and chicken gizzard . Regulation TGM2 CALM3 6126807 22255 *Effect* of inhibitor , Stelazine , on the endocytosis of vitellogenin and [transglutaminase] activity in Xenopus laevis oöcytes . Regulation TGM2 CALM3 7945671 276569 *regulates* nucleotide hydrolysis activity of [tissue transglutaminase] . Regulation TGM2 CALM3 7945671 276571 The *effect* of on the classical [transglutaminase] activity was minimal . Regulation TGM2 CAPN1 12859959 1111061 Also , the absence of or any detectable cysteine protease did not *affect* the [transglutaminase] activity in the erythrocyte lysate . Regulation TGM2 CAPN10 12859959 1111062 Also , the absence of or any detectable cysteine protease did not *affect* the [transglutaminase] activity in the erythrocyte lysate . Regulation TGM2 CAPN11 12859959 1111063 Also , the absence of or any detectable cysteine protease did not *affect* the [transglutaminase] activity in the erythrocyte lysate . Regulation TGM2 CAPN12 12859959 1111060 Also , the absence of or any detectable cysteine protease did not *affect* the [transglutaminase] activity in the erythrocyte lysate . Regulation TGM2 CAPN13 12859959 1111071 Also , the absence of or any detectable cysteine protease did not *affect* the [transglutaminase] activity in the erythrocyte lysate . Regulation TGM2 CAPN14 12859959 1111072 Also , the absence of or any detectable cysteine protease did not *affect* the [transglutaminase] activity in the erythrocyte lysate . Regulation TGM2 CAPN15 12859959 1111059 Also , the absence of or any detectable cysteine protease did not *affect* the [transglutaminase] activity in the erythrocyte lysate . Regulation TGM2 CAPN2 12859959 1111064 Also , the absence of or any detectable cysteine protease did not *affect* the [transglutaminase] activity in the erythrocyte lysate . Regulation TGM2 CAPN3 12859959 1111065 Also , the absence of or any detectable cysteine protease did not *affect* the [transglutaminase] activity in the erythrocyte lysate . Regulation TGM2 CAPN5 12859959 1111066 Also , the absence of or any detectable cysteine protease did not *affect* the [transglutaminase] activity in the erythrocyte lysate . Regulation TGM2 CAPN6 12859959 1111067 Also , the absence of or any detectable cysteine protease did not *affect* the [transglutaminase] activity in the erythrocyte lysate . Regulation TGM2 CAPN7 12859959 1111068 Also , the absence of or any detectable cysteine protease did not *affect* the [transglutaminase] activity in the erythrocyte lysate . Regulation TGM2 CAPN8 12859959 1111069 Also , the absence of or any detectable cysteine protease did not *affect* the [transglutaminase] activity in the erythrocyte lysate . Regulation TGM2 CAPN9 12859959 1111070 Also , the absence of or any detectable cysteine protease did not *affect* the [transglutaminase] activity in the erythrocyte lysate . Regulation TGM2 CD79A 10759247 683103 Purified and IgG had no *effect* on [transglutaminase] activity . Regulation TGM2 CD79A 24130874 2853364 Thioredoxin is *involved* in endothelial cell extracellular [transglutaminase 2] activation mediated by celiac disease patient . Regulation TGM2 CNR1 12815050 1134372 Evidence that anandamide inhibits epidermal differentiation through receptor *dependent* inhibition of protein kinase C , activation protein-1 , and [transglutaminase] . Regulation TGM2 CNR1 12815050 1134386 We also show that exogenous AEA inhibits the formation of cornified envelopes , a hallmark of keratinocyte differentiation , in HaCaT and NHEK cells treated with TPA plus calcium , through a *dependent* reduction of [transglutaminase] and protein kinase C activity . Regulation TGM2 EEF2K 24193916 2897122 Furthermore , *regulates* the expression of [tissue transglutaminase] ( TG2 ) , an enzyme previously implicated in proliferation , drug resistance and survival of cancer cells . Regulation TGM2 EGF 15369700 1297133 In this work , we tested the *effects* of all-trans retinoic acid and , used alone or in combination , on [transglutaminase] activity in a squamous , epithelial carcinoma cell line , HEp-2 . Regulation TGM2 EGF 2444479 78531 In the absence of FCS , however , did not inhibit steroid induced alpha-type keratinization and did not *affect* either steroid induced epidermal [transglutaminase] activity or amount of epidermal glucocorticoid receptor . Regulation TGM2 EGF 2444479 78538 Hence , the *effect* of on glucocorticoid induced epidermal [transglutaminase] activity was observed only in the presence of delipidized FCS and might be supported by an increase in the amount of glucocorticoid receptor . Regulation TGM2 EPHB2 21525012 2439798 We further determined JNK and , but not Akt and NF-?B , are *responsible* for EGFR mediated [TGM2] expression . Regulation TGM2 FOS 23592781 2794989 We demonstrate that *regulates* induction of [TGase2] expression after wounding but does not affect expression of the components of the well characterized complement-like system . Regulation TGM2 HLA-DQB1 18728523 1956171 dose *effect* on RIA [anti-tissue transglutaminase] autoantibody levels and clinicopathological expressivity of celiac disease . Regulation TGM2 IL17A 24116291 2714695 As an alternative cell culture system for NHKs , HaCaT cells can be used to study molecular mechanisms associated with abnormal HBD2 and [TGM2] expression in *response* to IFN? , IL-4 or . Regulation TGM2 IL4 24116291 2714696 As an alternative cell culture system for NHKs , HaCaT cells can be used to study molecular mechanisms associated with abnormal HBD2 and [TGM2] expression in *response* to IFN? , or IL-17A . Regulation TGM2 IL6 8096510 214570 We examined the *effect* of on the expression of [transglutaminase] in human hepatoblastoma HepG2 cells . Regulation TGM2 LGALS3BP 20049854 2200693 Cyclophilin C-associated colocalizes with calnexin and *regulates* the expression of [tissue transglutaminase] . Regulation TGM2 MT-CO2 17618715 1787013 During the study period , the fertilization *effect* dominated ozone and climatic stresses ( temperature and precipitation ) , and the combination of these multiple factors resulted in net accumulation of [0.9Tg C] in this ecosystem . Regulation TGM2 MYLIP 22294552 2551809 The data showed that [transglutaminase 2 (TGM2)] was directly *regulated* by . Regulation TGM2 NGF 7916448 269805 Blockade *effect* of on GM1 ganglioside induced activation of [transglutaminase] in superior cervical sympathetic ganglia excised from adult rat . Regulation TGM2 PRL 6145646 38696 [Transglutaminase ( TGase )] activity was not *affected* in any significant manner by or CyA in most tissues studied . Regulation TGM2 PTEN 18381937 1892947 [Tissue transglutaminase] *regulates* focal adhesion kinase/AKT activation by modulating expression in pancreatic cancer cells . Regulation TGM2 RAC1 17680210 1842392 *role* of and FAK in the induction of [transglutaminase II] . Regulation TGM2 RARS 1705423 152880 The *involvement* of in the induction of [tissue transglutaminase] ( TG ) by retinoic acid in rat tracheal 2C5 cells was determined . Regulation TGM2 TGFB1 1972706 135367 This study examines the *effect* of ( TGF-beta 1 ) on the expression of Type I and II [transglutaminase] in normal human epidermal keratinocytes ( NHEK cells ) . Regulation TGM2 TGFB1 9582307 503876 The TRE through which *regulated* the activity of the [transglutaminase] promoter was necessary and sufficient for bone morphogenetic protein 2- (BMP) and BMP4 dependent inhibition of the tissue transglutaminase promoter . Regulation TGM2 TNF 1675987 160957 had little *effect* on cornified envelope formation and [transglutaminase] activity in the preconfluent cells . Regulation TGM2 TNFRSF11B 24265865 2869850 All together , and Tgase-2 is induced by IL-1ß or TPA in MG-63 cells and [Tgase-2] is *involved* in OPG expression in MG-63 cells . Regulation TGM2 TXN 24130874 2853365 To investigate the role of , a novel *regulator* of extracellular [transglutaminase 2 (TG2)] , in celiac patients IgA ( CD IgA ) mediated TG2 enzymatic activation . Regulation TGM3 CAPN8 12859959 1111083 Also , the absence of or any detectable cysteine protease did not *affect* the [transglutaminase] activity in the erythrocyte lysate . Regulation TGM3 CST6 20495178 2319861 Biochemical evidence suggests that *controls* the activity of legumain , cathepsin L , cathepsin V , and [transglutaminase-3] . Regulation TGM3 TNF 1675987 160958 had little *effect* on cornified envelope formation and [transglutaminase] activity in the preconfluent cells . Regulation TGM4 CAPN8 12859959 1111097 Also , the absence of or any detectable cysteine protease did not *affect* the [transglutaminase] activity in the erythrocyte lysate . Regulation TGM4 TNF 1675987 160959 had little *effect* on cornified envelope formation and [transglutaminase] activity in the preconfluent cells . Regulation TGM5 CAPN8 12859959 1111111 Also , the absence of or any detectable cysteine protease did not *affect* the [transglutaminase] activity in the erythrocyte lysate . Regulation TGM5 TNF 1675987 160960 had little *effect* on cornified envelope formation and [transglutaminase] activity in the preconfluent cells . Regulation TGM6 CAPN8 12859959 1111125 Also , the absence of or any detectable cysteine protease did not *affect* the [transglutaminase] activity in the erythrocyte lysate . Regulation TGM6 TNF 1675987 160961 had little *effect* on cornified envelope formation and [transglutaminase] activity in the preconfluent cells . Regulation TGM7 CAPN8 12859959 1111139 Also , the absence of or any detectable cysteine protease did not *affect* the [transglutaminase] activity in the erythrocyte lysate . Regulation TGM7 TNF 1675987 160962 had little *effect* on cornified envelope formation and [transglutaminase] activity in the preconfluent cells . Regulation THBD TNF 10602073 655221 Endothelial cells ( EC ) from human aortas , microvessels , and pulmonary arteries were examined for their expression and activity of monocyte chemotactic protein-1 (MCP-1) , tissue factor , and [thrombomodulin] in *response* to on the hydrophilic plasma polymers gamma-butyrolactone ( GBL ) and N-vinyl-2-pyrrolidone ( NVP ) , along with a fibronectin (FN) control . Regulation THBD TNF 15733976 1378042 The objective of this study was to elucidate the *effects* of on the expression of [thrombomodulin (TM)] and endothelial protein C receptor (EPCR) in human endothelial cells as well as the effect of curcumin , a spice and coloring food compound , as a potential therapeutic agent . Regulation THBD TNF 1846762 153347 Expression of thrombomodulin by smooth muscle cells in culture : different *effects* of and cyclic adenosine monophosphate on [thrombomodulin] expression by endothelial cells and smooth muscle cells in culture . Regulation THBD TNF 1846763 153348 *Regulation* of [thrombomodulin] by : comparison of transcriptional and posttranscriptional mechanisms . Regulation THBD TNF 22405819 2577292 Simvastatin blocked the suppressive *effect* on [thrombomodulin] and eNOS , irrespective of shear stress . Regulation THBD TNF 2555368 122021 The different *effects* of PMA and on [thrombomodulin] expression indicate that some effects of TNF are not mediated solely by protein kinase C . Regulation THBD TNF 8747795 344098 is *involved* in the production of endothelin-1 and [thrombomodulin] , which play a role in the pathogenesis of DIC and whose blood levels reflect its severity . Regulation THBD TNF 8822923 384856 [Thrombomodulin] expression in endothelial cells is *regulated* by retinoic acid and , agents that also modulate epidermal differentiation . Regulation THBD TNF 8822923 384857 We examined [thrombomodulin] function and *regulation* of thrombomodulin expression by all-trans retinoic acid ( ATRA ) and in human keratinocytes and endothelial cells . Regulation THBD TNF 8822923 384860 These results demonstrate that keratinocyte [thrombomodulin] is *regulated* by retinoids and Ca2+ , but not by , and that regulation of thrombomodulin expression differs in keratinocytes and endothelial cells . Regulation THBD TNF 9701273 525278 Our aim was to express human TM cofactor activity in PAEC and to study the proinflammatory *effect* of on stable expressed human [thrombomodulin] in vitro . Regulation THBS1 ADAMTS1 20103648 2201972 The principal antiangiogenic activity of [TSP1] resides in a domain containing three TSP1 repeats ( 3TSR ) , and TSP1 cleavage is *regulated* , in part , by the metalloproteinase . Regulation THBS1 ADAMTS1 20103648 2201975 Collectively , our results indicate that the antiangiogenic activity of [TSP1] is differentially *regulated* by in the liver and lung , emphasizing the concept that regulation of angiogenesis is varied in different tissue environments . Regulation THBS1 EPHB2 15672871 1350782 In summary , our results show that the increase in phosphorylation induced by DFMO *plays* a critical role in the anti-invasive action of the drug and in its ability to upregulate [TSP-1] production . Regulation THBS1 FOXO1 23677673 2838405 We provide evidence that directly *regulates* [THBS1] within ischemic muscle . Regulation THBS1 ID1 12498716 1026397 We conclude that [TSP-1] is a major *target* for effects on angiogenesis . Regulation THBS1 ID1 21307796 2457927 negatively *regulates* [TSP-1] expression in AVM-ECs . Regulation THBS1 PLAU 18321763 1925034 Zymography experiments revealed that the dependent proteolytic activity is directly *controlled* by [TSP-1] , MMPs activity is not . Regulation THRA TNF 16945012 1609913 Compound 1 did not affect the or lipopolysaccharide induced [TRAP-luciferase] *response* , suggesting selective inhibition of the RANKL induced pathway . Regulation THRAP3 TNF 16945012 1609925 Compound 1 did not affect the or lipopolysaccharide induced [TRAP-luciferase] *response* , suggesting selective inhibition of the RANKL induced pathway . Regulation TIE1 ANGPT1 15370298 1297361 To study a potential feedback system in the angiopoietin (Ang)-Tie2 system , the authors examined *effects* of and Ang2 on [Tie2] expression on human umbilical vein endothelial cells ( HUVECs ) with or without stimulation by a potent inflammatory cytokine , tumor necrosis factor-alpha (TNF-alpha) . Regulation TIE1 ANGPT1 15370298 1297368 *Regulation* of [Tie2] expression by or Ang2 was not dependent on phosphatidylinositol 3-kinase . Regulation TIE1 ANGPT1 19615361 2124096 The major intracellular signaling systems activated by [Tie2] in *response* to include the Akt and Erk1/2 pathways . Regulation TIE1 TNF 13130465 1140036 In addition , we observed that can *regulate* [Tie2] activation in multiple ways that may involve interactions between endothelial cells and synoviocytes . Regulation TIMP1 IL1B 11029344 739831 Airway macrophages from smokers released greater amounts of MMP-9 and [TIMP-1] at baseline and in *response* to and LPS than did those of nonsmokers . Regulation TIMP1 IL1B 12527330 1048285 Rhein partially reversed the *effect* of on [TIMP-1] and NO production , had no effect on AGG , IL-6 and MIP-1beta production , but up-regulated the IL-1beta stimulated PGE ( 2 ) production . Regulation TIMP1 IL1B 12913942 1129705 The procedure also weakly reversed the inhibitory *effect* of on [TIMP-1] production . Regulation TIMP1 IL1B 15458430 1301525 TNF-alpha and mediated *regulation* of MMP-9 and [TIMP-1] in renal proximal tubular cells . Regulation TIMP1 IL1B 15458430 1301536 The differential *effects* of TNF-alpha and on proximal tubular MMP-9 and [TIMP-1] expression are mediated through the TNF-RI , the IL-1-RI and the different signaling pathways of PKC , ERK1/2 , and p38 MAPK . Regulation TIMP1 IL1B 17890880 1811205 TNF-alpha and mediated *regulation* of MMP-9 and [TIMP-1] in human glomerular mesangial cells . Regulation TIMP1 IL1B 18824875 1981581 Therefore we examined the potential role of nitric oxide ( NO ) in the *regulation* of MMP-9 and [TIMP-1] by tumour necrosis factor-alpha (TNF-alpha) and using the human mesangial cell line ( HMCL ) . Regulation TIMP1 IL1B 20471972 2288523 Different concentration PMA enhanced [TIMP-1] mRNA expression , but did not *affect* the TIMP-1 mRNA expression . Regulation TIMP1 IL1B 8591995 350627 The *effects* of and TGF-beta on the biosynthesis of extracellular matrix structural components relative to the metalloproteinases and their inhibitor [TIMP1] in human articular chondrocytes were investigated . Regulation TIMP1 IL1B 9357863 462080 Divergent regulation of 92-kDa gelatinase and [TIMP-1] by HBECs in *response* to and TNF-alpha . Regulation TIMP1 IL1B 9357863 462089 Quantitative RT-PCR demonstrated that [TIMP-1] mRNA levels remained unchanged in *response* to LPS or but decreased by 70 % in the presence of TNF-alpha . Regulation TIMP1 IL1B 9589682 505342 We have investigated the *roles* of and transforming growth factor-beta ( TGF beta ) in regulating [TIMP-1] , TIMP-3 , and 92-kDa type IV collagenase messenger ribonucleic acid ( mRNA ) expression in human endometrial stromal cells using quantitative competitive PCR . Regulation TIMP1 IL1B 9727371 529928 The present study examines the *effect* of transforming growth factor-beta1 ( TGF-beta1 ) and on the regulation of gelatinase A , gelatinase B , tissue inhibitor of metalloproteinase-I ( [TIMP-I] ) and TIMP-II in human glomerular epithelial cells ( GEC ) . Regulation TIMP1 IL1B 9743373 532499 Differential *regulation* of monocyte matrix metalloproteinase and [TIMP-1] production by TNF-alpha , granulocyte-macrophage CSF , and through prostaglandin dependent and -independent mechanisms . Regulation TIMP1 MMP28 18273688 1937968 The enhancing activity of [TIMP-1] was *dependent* , since a mutant version of TIMP-1 was unable to promote angiogenesis . Regulation TIMP1 MMP28 18973523 2041324 The *effect* of inhibitors on gel contraction and on MMP and [TIMP] expression was analyzed . Regulation TIMP1 MMP28 7727689 288778 The biological activity of is *controlled* by [tissue inhibitor of MMP (TIMP)] which also depends on the presence of cytokines in the microenvironment . Regulation TIMP1 MMP28 9433928 474595 The results suggest that MMP and [TIMP] expression in leiomyoma and myometrium are hormonally *regulated* , and that GnRHa induced tumour regression is accompanied by an increase in expression with a concomitant decrease in TIMP-1 expression , which may potentially provide an environment favouring ECM degradation . Regulation TIMP1 MMP7 18273688 1937983 The enhancing activity of [TIMP-1] was *dependent* , since a mutant version of TIMP-1 was unable to promote angiogenesis . Regulation TIMP1 MMP7 18973523 2041339 The *effect* of inhibitors on gel contraction and on MMP and [TIMP] expression was analyzed . Regulation TIMP1 MMP7 7727689 288793 The biological activity of is *controlled* by [tissue inhibitor of MMP (TIMP)] which also depends on the presence of cytokines in the microenvironment . Regulation TIMP1 MMP7 9433928 474610 The results suggest that MMP and [TIMP] expression in leiomyoma and myometrium are hormonally *regulated* , and that GnRHa induced tumour regression is accompanied by an increase in expression with a concomitant decrease in TIMP-1 expression , which may potentially provide an environment favouring ECM degradation . Regulation TIMP1 PLAU 10534069 562517 [TIMP-1] *controls* the synthesis of in the PDL cells . Regulation TIMP1 TLR7 23223421 2803397 This study demonstrates profibrotic properties of circulating monocytes from patients with SSc and a key *role* for signalling , particularly TLR8 , in [TIMP-1] secretion and matrix remodelling . Regulation TIMP1 TNF 10362800 620153 increased secretion of procathepsin S , but did not *affect* [TIMP-1] and reduced TIMP-2 production . Regulation TIMP1 TNF 14998513 1216638 Differential *regulation* of gelatinase A and B and [TIMP-1] and -2 by and HIV virions in astrocytes . Regulation TIMP1 TNF 15458430 1301535 The differential *effects* of and IL-1beta on proximal tubular MMP-9 and [TIMP-1] expression are mediated through the TNF-RI , the IL-1-RI and the different signaling pathways of PKC , ERK1/2 , and p38 MAPK . Regulation TIMP1 TNF 18824875 1981580 Therefore we examined the potential role of nitric oxide ( NO ) in the *regulation* of MMP-9 and [TIMP-1] by and interleukin-1 beta (IL-1 beta) using the human mesangial cell line ( HMCL ) . Regulation TIMP1 TNF 2167246 140131 Furthermore , the fact that and IL-1 differently *controlled* the production of [TIMP] suggests that the signal pathway of TNF for TIMP production is different from that of IL-1 . Regulation TIMP1 TNF 2175694 145831 In this study , the *effect* of on the induction of collagenase and tissue inhibitor of metalloproteinases ( [TIMP] ) was examined . Regulation TIMP1 TNF 8088923 271673 We have investigated the *effect* of on the synthesis and/or steady-state mRNA levels of collagen , alkaline phosphatase (ALP) , plasminogen activators (PAs) and their inhibitor PAI-1 , and collagenases ( MMPs ) and their inhibitor [TIMP-1] by human osteoblastic , HOS TE85 , cells in monolayer cultures . Regulation TIMP1 TNF 9357863 462079 Divergent regulation of 92-kDa gelatinase and [TIMP-1] by HBECs in *response* to IL-1beta and . Regulation TIMP1 TNF 9743373 532497 Differential *regulation* of monocyte matrix metalloproteinase and [TIMP-1] production by , granulocyte-macrophage CSF , and IL-1 beta through prostaglandin dependent and -independent mechanisms . Regulation TIMP2 EPHB2 16904070 1601385 signaling *regulates* concanavalin A-dependent production of [TIMP-2] . Regulation TIMP2 IL1B 9727371 529930 The present study examines the *effect* of transforming growth factor-beta1 ( TGF-beta1 ) and on the regulation of gelatinase A , gelatinase B , tissue inhibitor of metalloproteinase-I ( TIMP-I ) and [TIMP-II] in human glomerular epithelial cells ( GEC ) . Regulation TIMP2 TNF 10362800 620154 increased secretion of procathepsin S , but did not *affect* TIMP-1 and reduced [TIMP-2] production . Regulation TIMP2 TNF 10996723 733899 We have investigated the *effects* of and interferon ( INF-gamma ) , the potent Bacillus Calmette-Guerin ( BCG ) -induced cytokines on the production of MMP-2 , MMP-9 , TIMP-1 , [TIMP-2] and MT1-MMP in high grade human bladder cancer cell lines , T-24 , J-82 and HT-1376 cell lines . Regulation TIMP2 TNF 14998513 1216639 Differential *regulation* of gelatinase A and B and [TIMP-1 and -2] by and HIV virions in astrocytes . Regulation TIMP2 TNF 14998513 1216643 TIMP-1 and [TIMP-2] levels were *affected* only slightly , if at all , by HIV and . Regulation TIMP2 TNF 15090307 1237862 The *effect* of exogenous and anti-TNF-alpha on the expression of matrix metalloproteinase-2 (MMP-2) and [tissue inhibitor of metalloproteinases-2] ( TIMP-2 ) in human trophoblastic cells was investigated with reverse transcription ( RT ) -PCR ( RT-PCR ) . Regulation TIMP2 TNF 8280080 240545 On the other hand , MMP-2 and [TIMP-2] were not affected or were *affected* in a variable way by and/or phorbol ester , suggesting a dissimilar regulation of these proteins . Regulation TIMP3 CTGF 17133596 1661442 However , the regulatory role of CTGF on SPARC appeared to be negative and very small , while the positive regulatory *effects* of on COL1A2 , COL3A1 , COL11A1 , and [TIMP3] were less than those of SPARC . Regulation TIMP3 IL1B 9589682 505346 We have investigated the *roles* of and transforming growth factor-beta ( TGF beta ) in regulating TIMP-1 , [TIMP-3] , and 92-kDa type IV collagenase messenger ribonucleic acid ( mRNA ) expression in human endometrial stromal cells using quantitative competitive PCR . Regulation TIMP4 F2R 20422465 2274546 Although matrix metalloproteinase-9 (MMP-9) is involved in cardiomyocytes contractility dysfunction , [tissue inhibitor of metalloproteinase-4] ( TIMP-4 ) mitigates the effect of MMP-9 , and ( PAR-1 , a G-protein couple receptor , GPCR ) is *involved* in the signaling cascade of MMP-9 mediated cardiac dysfunction , the mechanism ( s ) are unclear . Regulation TIRAP TLR7 16239509 1471052 We also determined that MyD88 , IRAK , TRAF6 , and Toll interacting protein (Tollip) , but not [TIRAP] , were involved in the mediated *response* to P. aeruginosa in HAECs . Regulation TJP1 ANGPT1 17332770 1834987 To determine the *effects* of pericytes and on the expression of occludin and [zonula occludens-1 (ZO-1)] in retinal endothelial cells ( ECs ) under both normoxic and hypoxic conditions . Regulation TJP1 ANGPT1 23894369 2821833 Recombinant human sonic hedgehog protein *regulates* the expression of [ZO-1] and occludin by activating in stroke damage . Regulation TJP1 CAPN8 22931549 2693157 PM-activated is *responsible* for [ZO-1] degradation and EC barrier disruption . Regulation TJP1 IL1B 19171646 2027685 The NF-kappaB inhibitor curcumin blocked the *effects* of on both TER and the subcellular localization of [ZO-1] and occludin . Regulation TJP1 TNF 18235000 1864340 The abundance of neither [ZO-1] nor occludin was *affected* by . Regulation TJP1 TNF 19772664 2147498 The *roles* of in colon [tight junction protein] expression and intestinal mucosa structure in a mouse model of acute liver failure . Regulation TJP2 ANGPT1 19148554 2026685 Herein , we examined whether could *regulate* [zonula occludens-2 (ZO-2)] expression and counteract vascular endothelial growth factor ( VEGF ) -induced vascular permeability . Regulation TJP2 TNF 19772664 2147499 The *roles* of in colon [tight junction protein] expression and intestinal mucosa structure in a mouse model of acute liver failure . Regulation TJP3 TNF 19772664 2147500 The *roles* of in colon [tight junction protein] expression and intestinal mucosa structure in a mouse model of acute liver failure . Regulation TLN1 CAPN8 12490576 1033315 The goal of the present study was to determine the *role* of in changes in plasma membrane permeability and cytoskeleton associated paxillin , vinculin , [talin] , and alpha-actinin levels during acute renal cell death . Regulation TLN1 CAPN8 20709086 2341001 Altogether , our results reveal that *dependent* cleavage of [talin] modulates cell contractile dynamics , which in pericytes may prove instrumental in controlling normal capillary function or microvascular pathophysiology . Regulation TLN2 CAPN8 12490576 1033329 The goal of the present study was to determine the *role* of in changes in plasma membrane permeability and cytoskeleton associated paxillin , vinculin , [talin] , and alpha-actinin levels during acute renal cell death . Regulation TLN2 CAPN8 20709086 2341015 Altogether , our results reveal that *dependent* cleavage of [talin] modulates cell contractile dynamics , which in pericytes may prove instrumental in controlling normal capillary function or microvascular pathophysiology . Regulation TLR1 CCL17 18557811 1972053 These results suggest that the CCL17 produced by HGFs may be involved in the migration of Th2 cells into inflamed tissues , and provide evidence that production is *controlled* by cytokines and [TLR] ligands in periodontal disease . Regulation TLR1 TNF 7780485 309474 The *effect* of on cytotoxic activity of [tumor infiltrating lymphocytes (TIL)] was investigated . Regulation TLR1 TNF 7882388 298853 The enhanced cytotoxicity was ascribed to autocrine *effects* of secreted on [TIL] , which included augmentation of adhesion molecule ( CD2 and CD11a ) and interleukin-2 receptor expression , and elevation of production of interferon gamma , lymphotoxin and granulocyte/macrophage-colony stimulating factor and its paracrine effect on target cells to facilitate them to be more susceptible to TIL . Regulation TLR10 CCL17 18557811 1972061 These results suggest that the CCL17 produced by HGFs may be involved in the migration of Th2 cells into inflamed tissues , and provide evidence that production is *controlled* by cytokines and [TLR] ligands in periodontal disease . Regulation TLR2 CCL17 18557811 1972054 These results suggest that the CCL17 produced by HGFs may be involved in the migration of Th2 cells into inflamed tissues , and provide evidence that production is *controlled* by cytokines and [TLR] ligands in periodontal disease . Regulation TLR2 IL1B 15961329 1458715 Expression and *regulation* of [Toll-like receptor 2] by and fibronectin fragments in human articular chondrocytes . Regulation TLR2 IL1B 19666104 2182970 In particular , there was a marked increase in pro-inflammatory IL-1beta , IL-6 , and TNFalpha responses following [TLR 2] , and *response* following TLR 4 stimulation in monocyte cultures from children with ASD ( p < 0.04 ) . Regulation TLR2 IL1R2 21303924 2414685 Differential *role* of domain containing adaptor protein in [Toll-like receptor 2-mediated] regulation of gene expression of hepatic cytokines and drug metabolizing enzymes . Regulation TLR2 TLR7 16950283 1610307 Expression of [TLR2] , TLR3 , and TLR4 is *regulated* by cytokines and ligands , and their activation mediates chemokine release in ASMCs . Regulation TLR2 TLR7 23573259 2768104 [Toll-Like Receptor (TLR) -2] and -4 expression and induced cytokine *response* of inflammatory cells are related to atherogenesis and atherosclerotic plaque progression . Regulation TLR2 TNF 12763043 1093840 The results demonstrated three patterns of gene expression : the [TLR2] and myeloid differentiation factor 88 ( MyD88 ) gene expressions were induced in AM in *response* to lipopolysaccharide (LPS) , interleukin (IL)-1beta , or or in the lung tissue of an LPS induced acute lung injury model ; Regulation TLR2 TNF 17961202 1815035 *regulates* [Toll-like receptor 2 (TLR2)] expression in microglia . Regulation TLR2 TNF 17961202 1815038 To determine the downstream signaling events responsible for elevated microglial [TLR2] expression in *response* to , a series of signal transduction inhibitors were employed . Regulation TLR2 TNF 18550705 1945938 In addition , TNF-alpha treatment in THP-1 cells induced TLR2 production in response to mechanical stress , whereas the preincubation of anti-TNF-alpha antibody scarcely induced the mechanical stress mediated production of TLR2 , indicating that produced by mechanically stimulated THP-1 cells *affected* [TLR2] production . Regulation TLR2 TNF 18550705 1945939 We concluded that production induced by centrifugation mediated mechanical stress is dependent on MyD88 dependent TLR2 signaling that is associated with Ca ( 2+ ) release and that TNF-alpha production induced by mechanical stress *affects* [TLR2] production . Regulation TLR2 TNF 22227093 2544563 In this study , we investigated the *effects* of the pro-inflammatory cytokine on [TLR2] expression in human gingival fibroblasts . Regulation TLR2 TNF 24349383 2881278 This increase was mediated by the engagement of [Toll like receptor-2] , and was *independent* of or nitric oxide production . Regulation TLR3 CCL17 18557811 1972055 These results suggest that the CCL17 produced by HGFs may be involved in the migration of Th2 cells into inflamed tissues , and provide evidence that production is *controlled* by cytokines and [TLR] ligands in periodontal disease . Regulation TLR3 TLR7 16950283 1610317 Expression of TLR2 , [TLR3] , and TLR4 is *regulated* by cytokines and ligands , and their activation mediates chemokine release in ASMCs . Regulation TLR4 ADRB2 19167076 2043521 *regulate* [Toll-like receptor 4-induced] late-phase NF-kappaB activation . Regulation TLR4 CCL17 18557811 1972056 These results suggest that the CCL17 produced by HGFs may be involved in the migration of Th2 cells into inflamed tissues , and provide evidence that production is *controlled* by cytokines and [TLR] ligands in periodontal disease . Regulation TLR4 CD14 24275652 2898377 We conclude that has a critical role in mediating TLR4 signaling through IRF3 in resident corneal epithelial cells and macrophages and thereby *modulates* [TLR4] cell surface activation of the MyD88/NF-?B/AP-1 pathway and production of CXC chemokines and neutrophil infiltration to infected tissues . Regulation TLR4 HES2 20689135 2299293 The infusion of HES130/0.4 in endotoxemic rats , especially 15 ml/kg , significantly reduced the release of plasma TNF-alpha and IL-1beta , which was consistent with the observed inhibitory *effects* of on NF-kappaB activation , TLR4 mRNA expression , and [TLR4] protein level in monocytes . Regulation TLR4 IL1B 15509550 1328042 The *role* of in direct and [toll-like receptor 4-mediated] neutrophil activation and survival . Regulation TLR4 PECAM1 18025177 1827642 ligation negatively *regulates* [TLR4] signaling in macrophages . Regulation TLR4 SPHK1 20661259 2388857 The *involvement* of in LPS induced [Toll-like receptor 4-mediated] accumulation of HIF-1a protein , activation of ASK1 and production of the pro-inflammatory cytokine IL-6 . Regulation TLR4 TLR7 16950283 1610327 Expression of TLR2 , TLR3 , and [TLR4] is *regulated* by cytokines and ligands , and their activation mediates chemokine release in ASMCs . Regulation TLR4 TLR7 23573259 2768114 [Toll-Like Receptor (TLR) -2 and -4] expression and induced cytokine *response* of inflammatory cells are related to atherogenesis and atherosclerotic plaque progression . Regulation TLR4 TNF 11923281 947224 IFN-gamma regulates MD-2 expression in both IEC lines , whereas IFN-gamma and *regulate* [TLR4] mRNA expression in IEC lines . Regulation TLR4 TNF 15871126 1405652 Anti-TNF- alpha antibody blocked increases in TLR4 mRNA expression induced by CVL samples from women with BV , indicating that *plays* a critical role in induction of [TLR4] . Regulation TLR4 TNF 17496895 1744443 Our results indicate that two different [TLR4] complexes sequentially form and selectively *control* early and late production . Regulation TLR4 TNF 19106809 2093288 Although inflammatory capacity and TNF-alpha synthesis were altered on monocytes after cardiopulmonary bypass (CPB) , whether the CPB and the CPB induced *affect* [TLR4] expression on monocytes have not yet clarified . Regulation TLR4 TNF 20550880 2279631 Up-regulating the expression of occludin and down *regulating* the expressions of [TLR4] and NF-kappaB , and hence inhibiting expression and improving the mucosa barrier function may be part of the mechanisms of BWXLS in treating oxazolone induced colitis in mice . Regulation TLR5 CCL17 18557811 1972057 These results suggest that the CCL17 produced by HGFs may be involved in the migration of Th2 cells into inflamed tissues , and provide evidence that production is *controlled* by cytokines and [TLR] ligands in periodontal disease . Regulation TLR6 CCL17 18557811 1972062 These results suggest that the CCL17 produced by HGFs may be involved in the migration of Th2 cells into inflamed tissues , and provide evidence that production is *controlled* by cytokines and [TLR] ligands in periodontal disease . Regulation TLR7 ADAM15 23365087 2743258 In conclusion , to our knowledge , our study clearly shows for the first time that *plays* an unexpected role in [TLR] signaling , acting as an anti-inflammatory molecule through impairment of TRIF mediated TLR signaling . Regulation TLR7 ADIPOQ 22535177 2589987 [TLR] activation is mediated by fatty acids and their expression is *regulated* by leptin , and PPARs . Regulation TLR7 ANXA1 24048896 2851771 Our findings demonstrate that *plays* an important role in [TLR] activation , leading to an augmentation in the type 1 IFN antiviral cytokine response . Regulation TLR7 APC 19228816 2061877 This report addresses the potential contribution of dendritic cells ( DC ) to changes in adaptive immune function after injury by specifically measuring injury induced changes in splenic DC numbers and subsets , cell-surface markers , [TLR] *responses* , and function . Regulation TLR7 BCL10 17623099 1787135 The expression profile suggested PI3K/AKT activation and NF-kappaB activation through multiple pathways ( [TLR/IL1R] , TNF receptor induced and TCR-like possibly *involving* ) . Regulation TLR7 BST2 19564354 2104290 *Regulation* of [TLR7/9] responses in plasmacytoid dendritic cells by and ILT7 receptor interaction . Regulation TLR7 BTK 17520285 1857979 Our results do not indicate the essential *role* of in [TLR] signaling and DC development . Regulation TLR7 BTK 20634142 2316758 Bruton's tyrosine kinase (Btk) has been reported to mediate signaling through toll-like receptors ( TLRs ) in many cell types , however , the *role* of in [TLR] activation of neutrophils remains unclear . Regulation TLR7 CAMP 19166322 2061111 Correlations between the capacity of LL-37 fragments to modulate TLR responses and their physico-chemical properties revealed that cationicity and hydrophobicity are essential for the modulation of mediated [TLR] *responses* . Regulation TLR7 CAV1 21794945 2495154 Naip5 alleles had an effect on the [TLR-Il1R] signaling pathway , the cell cycle and the mediated *response* to pathogen . Regulation TLR7 CAV2 21794945 2495155 Naip5 alleles had an effect on the [TLR-Il1R] signaling pathway , the cell cycle and the mediated *response* to pathogen . Regulation TLR7 CAV3 21794945 2495156 Naip5 alleles had an effect on the [TLR-Il1R] signaling pathway , the cell cycle and the mediated *response* to pathogen . Regulation TLR7 CCL17 18557811 1972058 These results suggest that the CCL17 produced by HGFs may be involved in the migration of Th2 cells into inflamed tissues , and provide evidence that production is *controlled* by cytokines and [TLR] ligands in periodontal disease . Regulation TLR7 CD180 24115036 2867856 The *effects* of on [TLR] signaling vary for different leukocyte subsets known to be involved in atherosclerosis , making it unique in its role of either suppressing ( in myeloid cells ) or enhancing ( in B cells ) TLR regulated inflammation in different cell types . Regulation TLR7 CD200 22615569 2603880 receptor *controls* sex-specific [TLR7] responses to viral infection . Regulation TLR7 CD300LF 21536801 2429043 To investigate the *effect* of stimulation on [TLR] signaling , the human acute monocytic leukemia cell line THP-1 was treated with CD300F-specific mAbs or two synthetic peptides that represented the ITIM-like domains of CD300F . Regulation TLR7 CD4 24133169 2863884 Contribution of [TLR] signaling to the ( + ) T cell *responses* in chronic mice was supported by data obtained in mice lacking the MyD88 adaptor . Regulation TLR7 CD44 17277154 1697864 In this study , we examined the *role* of in acute pulmonary inflammation and in the regulation of [LPS-TLR] signaling . Regulation TLR7 CDC73 19843712 2196542 The *involvement* of leukotriene (LT) B ( 4 ) and in [TLR] ligand induced activation of inflammatory cell functions is essentially unknown . Regulation TLR7 CISH 15491991 1347407 Here we have elucidated the nature of the regulatory *role* of in [TLR] signaling . Regulation TLR7 CISH 22798678 2639944 1 *plays* a key role in the negative regulation of both [TLR-] and cytokine receptor mediated signaling , which is involved in innate immunity and subsequent adaptive immunity . Regulation TLR7 CLEC12A 16239426 1518112 Of interest , ligation had the opposite *effects* on [TLR] versus CD40L signaling : anti-DCAL-2 suppressed TLR induced IL-12 expression , but significantly enhanced CD40L induced IL-12 production . Regulation TLR7 CNP 23818205 2808311 and NPR-B showed different characteristic on renal cortex at different pathological period in diabetes rats , and [TLR] *regulated* their expression . Regulation TLR7 CSE 18217953 1918996 The main goal of this study was to explore the *effects* of on [Toll-like receptor (TLR)] expression and activation in a human bronchial epithelial cell line ( 16-HBE ) . Regulation TLR7 CSF2 20064484 2212091 G-CSF and did not *affect* [TLR] agonist induced phosphorylation of ERK , p38 , JNK , Akt , and IkappaBalpha . Regulation TLR7 CSF3 20064484 2212076 We studied the *effect* of on [TLR] agonist induced cytokine production in human neutrophils . Regulation TLR7 CSF3 20064484 2212092 and GM-CSF did not *affect* [TLR] agonist induced phosphorylation of ERK , p38 , JNK , Akt , and IkappaBalpha . Regulation TLR7 CSF3 24518205 2955891 These data suggest that low-level [TLR] agonist production by commensal flora contributes to the regulation of HSC function and that negatively *regulates* HSCs , in part , by enhancing TLR signaling . Regulation TLR7 CTR9 19843712 2196543 The *involvement* of leukotriene (LT) B ( 4 ) and in [TLR] ligand induced activation of inflammatory cell functions is essentially unknown . Regulation TLR7 DAP 23459077 2776464 Depending on the cell type , activation *plays* an important role in activation and differentiation of osteoclasts , phagocytosis of bacteria , brain and bone homeostasis and inhibition of the [toll-like receptor (TLR)] signaling in macrophages and dendritic cells . Regulation TLR7 DDX58 22540943 2608310 The observed blockage of TLR3 , [TLR7] , TLR9 , and mediated IFN-a *response* appears to be driven by a competitive mechanism at the type I IFN pathway . Regulation TLR7 DOK3 22761938 2623331 Thus , *plays* a role in [TLR] signaling during both naïve and endotoxin induced tolerant conditions . Regulation TLR7 EEF1A2 21964955 2522113 Mechanistic studies using specific pathway inhibitors and rescue experiments show that induced inhibition of cholesterol biosynthesis , rather than inhibition of isoprenylation , was mainly *responsible* for the amplified [TLR] responses . Regulation TLR7 EGFR 18403779 1944264 Our findings identify a novel *dependent* mechanism for regulating [TLR] , and show that targeted disruption of EGFR signaling ameliorates the airway epithelial inflammatory response to pDNA . Regulation TLR7 FOXP3 17641056 1771320 We hypothesized that the transcription factor *regulates* the expression of [TLR] family members in human Treg cells . Regulation TLR7 GFI1 20547752 2295916 Here , we analyzed the *role* of the nuclear in the [TLR] response using primary bone marrow derived macrophages . Regulation TLR7 GNAS 15778388 1385066 In this study , we have extended these observations in human dermal microvessel endothelial cells ( HMEC ) that lack membrane bound CD14 and in murine macrophages to define further the *role* of proteins in [TLR] signaling . Regulation TLR7 GNB1 15778388 1385067 In this study , we have extended these observations in human dermal microvessel endothelial cells ( HMEC ) that lack membrane bound CD14 and in murine macrophages to define further the *role* of proteins in [TLR] signaling . Regulation TLR7 GNG2 15778388 1385068 In this study , we have extended these observations in human dermal microvessel endothelial cells ( HMEC ) that lack membrane bound CD14 and in murine macrophages to define further the *role* of proteins in [TLR] signaling . Regulation TLR7 GRAP2 24046015 2857391 Reasoning that IL-1ß might be involved in a like autoinhibitory loop , we determined that ( 1 ) [TLR] activation of FANCA- and FANCC-deficient macrophages induced overproduction of both TNF-a and IL-1ß in a *dependent* manner ; Regulation TLR7 GRK5 22078319 2528429 Together , our results demonstrate multiple *roles* of in [TLR] signaling . Regulation TLR7 HDAC1 23853092 2834869 A hypoxia-inducible factor (HIF) 1 binding site in this promoter was required for *dependent* [TLR-inducible] promoter activity and for Hdac7- and HIF-1a mediated trans-activation . Regulation TLR7 HDAC2 23853092 2834870 A hypoxia-inducible factor (HIF) 1 binding site in this promoter was required for *dependent* [TLR-inducible] promoter activity and for Hdac7- and HIF-1a mediated trans-activation . Regulation TLR7 HDAC7 23853092 2834921 Thus , positively *regulates* HIF-1a dependent [TLR] signaling in macrophages , whereas an interaction with CtBP1 likely prevents Hdac7-s from exerting this effect . Regulation TLR7 HRAS 17045653 1666647 The results demonstrate that for the first time that the small GTPase is *involved* in [TLR] signaling of avian heterophils with the TLR agonists LPS ( Ras ) and FLG ( Rap1 ) inducing differential signaling cascades to activate the downstream ERK MAP kinase . Regulation TLR7 HRAS 21665146 2442704 Whereas GPCRs activate p110? in a Ras/p101 dependent manner , RTKs and [TLR/IL1Rs] directly activate p110? in a *dependent* manner . Regulation TLR7 HTN3 24495360 2913704 It is possible that released HSC70 induces [toll-like receptor (TLR)] activation , just as extracellular HSP70 ( a stress inducible HSP ) does , and that *affects* this process . Regulation TLR7 IFN1@ 19624844 2137562 Our studies provide a critical link between the pathway and the *regulation* of [TLR-specific] B-cell responses in a murine model of SLE . Regulation TLR7 IL10 15919371 1353156 Moreover , the *involvement* of in [TLR] tolerance induction seems to be a more general phenomenon as shown by experiments using different TLR-agonists in IL-10 ( -/- ) macrophages . Regulation TLR7 IL1A 23872113 2830092 Pro B2 markedly elevated the expression of the receptor associated kinase ( IRAK)-M protein , a negative *regulator* of [TLR] signaling . Regulation TLR7 IL1R1 11937546 928164 *plays* a pivotal role in [IL-1R/Toll-like receptor (TLR)] mediated signaling and NF-kappaB activation . Regulation TLR7 IL6 22751696 2670363 [TLR] ligation also resulted in a diminished *response* in seropositive individuals as lower frequencies of IL-6 expressing monocytes and mDCs were induced . Regulation TLR7 IRAK2 17878161 1818389 Thus we propose that *plays* a more central role than IRAK-1 in [TLR] signaling to NFkappaB . Regulation TLR7 IRAK2 21606490 2450169 Thus IRAK-2 in mice and humans may function differently , and therefore we analyzed the *role* of in [TLR] responses in primary human cells . Regulation TLR7 IRAK2 21606490 2450238 Collectively , these data demonstrate for the first time an essential *role* for in primary human cells for both transcriptional and post-transcriptional [TLR] responses . Regulation TLR7 IRAK3 12150927 970907 Thus , *regulates* [TLR] signaling and innate immune homeostasis . Regulation TLR7 IRAK3 14660668 1202309 It was recently reported that negatively *regulates* [TLR] signaling . Regulation TLR7 IRAK3 16263713 1490049 Man-LAM exerts these effects by inducing the expression of , a negative *regulator* of [TLR] signaling . Regulation TLR7 IRAK3 19380811 2065774 Additionally , flagellin mediated induction of other inflammation markers , including il1b , il8 , and cxcl-C1c , was reduced upon Tlr5 knockdown as well as expression of , a putative negative [TLR] pathway *regulator* . Regulation TLR7 IRAK3 21182089 2373813 Interestingly , the expression of , a negative *regulator* of [TLR] signaling , is dependent on intestinal commensal flora , as IRAK-M expression was reduced in mice re-derived into a germ-free environment , and introduction of commensal bacteria into germ-free mice induced IRAK-M expression . Regulation TLR7 IRAK3 22154382 2563085 ( IRAK-M ) negatively *regulates* [TLR] signaling . Regulation TLR7 IRAK3 22472665 2589036 This study tested if murine bone marrow derived dendritic cells ( BM-DCs ) respond to endotoxin- and bacterial sonicate induced tolerance by decreased inflammatory and increased anti-inflammatory response , and the role of , an intracellular negative *regulator* of [TLR] signaling , in this tolerance . Regulation TLR7 IRAK3 23776703 2802374 , a negative *regulator* of [TLR] signaling , was upregulated and we selectedit for investigation of its role in modulating the DC and T cell responses . Regulation TLR7 IRAK3 23872113 2830091 Pro B2 markedly elevated the expression of the interleukin (IL)-1 receptor associated kinase ( protein , a negative *regulator* of [TLR] signaling . Regulation TLR7 IRAK4 16286015 1480925 Human [TLR-7-] , -8- , and -9-mediated induction of IFN-alpha/beta and -lambda Is *dependent* and redundant for protective immunity to viruses . Regulation TLR7 IRAK4 16286015 1480932 The [TLR-7-] , TLR-8- , and TLR-9 dependent induction of IFN-alpha/beta and -lambda is strictly *dependent* and paradoxically redundant for protective immunity to most viruses in humans . Regulation TLR7 IRAK4 18503546 1928207 *plays* an essential role in [Toll-like receptor (TLR)/IL-1] receptor signaling . Regulation TLR7 IRF1 17059692 1637146 Given that IRF-1 and IRF-2 counter-regulate the transcriptional activity of many genes , we hypothesized that and IRF-2 might also *regulate* [TLR] gene expression following LPS stimulation of murine macrophages . Regulation TLR7 IRF2 17059692 1637147 Given that IRF-1 and IRF-2 counter-regulate the transcriptional activity of many genes , we hypothesized that IRF-1 and might also *regulate* [TLR] gene expression following LPS stimulation of murine macrophages . Regulation TLR7 IRF4 16243976 1476884 These results imply that negatively *regulates* [TLR] signaling and is inhibitory to the production of proinflammatory cytokines in response to TLR stimulation . Regulation TLR7 IRF4 19890047 2165939 Following MDP stimulation in vivo , liver pDC , but not mDC , up-regulated expression of , a negative *regulator* of [TLR] signaling , and induced less allogeneic T cell proliferation and IFN-gamma production . Regulation TLR7 IRF7 22952664 2667450 We find that [TLR7] activation increases the expression of EBV LMP1 , and is *involved* in the stimulation process . Regulation TLR7 KRAS 17045653 1666648 The results demonstrate that for the first time that the small GTPase is *involved* in [TLR] signaling of avian heterophils with the TLR agonists LPS ( Ras ) and FLG ( Rap1 ) inducing differential signaling cascades to activate the downstream ERK MAP kinase . Regulation TLR7 KRAS 21665146 2442705 Whereas GPCRs activate p110? in a Ras/p101 dependent manner , RTKs and [TLR/IL1Rs] directly activate p110? in a *dependent* manner . Regulation TLR7 LEO1 19843712 2196546 The *involvement* of leukotriene (LT) B ( 4 ) and in [TLR] ligand induced activation of inflammatory cell functions is essentially unknown . Regulation TLR7 LILRA4 19564354 2104291 *Regulation* of [TLR7/9] responses in plasmacytoid dendritic cells by BST2 and receptor interaction . Regulation TLR7 LTA 15879147 1406088 In this study we examined the *role* of from GBS in phagocyte activation and the requirements for [TLR-LTA] interaction . Regulation TLR7 LTA 20303182 2273068 The aim of the present study was to gain better insight into the nature of the ligand for TLR15 by characterizing gene expression patterns of [TLR15] by heterophils in *response* to numerous bacterial derived TLR agonists LPS , flagellin , CpG oligodeoxynucleotides , , peptidoglycan ( PGN ) , and Pam3CSK4 (PAM) , stimulation with live Salmonella enterica serovar Enteritidis ( SE-used as a positive control ) , chicken isolates of Escherichia coli ( EC ) and Enterococcus gallinarum ( EG ) , the equine-specific pathogen Rhodococcus equi , and stimulation with heat killed , and formalin killed SE , EC , and EG . Regulation TLR7 LTB 19843712 2196547 The *involvement* of ( 4 ) and platelet activating factor (PAF) in [TLR] ligand induced activation of inflammatory cell functions is essentially unknown . Regulation TLR7 LTB 22119018 2548437 Additionally , the production of LTB ( 4 ) and PGE ( 2 ) were inhibited following treatment of heterophils with the specific pharmacologic inhibitor of NF-?B ( Bay 11-7086 ) , thus suggesting that [TLR] pathway activation of NF-?B *controls* ( 4 ) and PGE ( 2 ) production . Regulation TLR7 LY96 15285420 1278027 Importantly , while *regulation* of [TLR] expression and distribution is well established , determining whether the interaction is direct or not will require further study . Regulation TLR7 LYN 20385881 2262032 We demonstrate in this study that the Src family kinase negatively *regulates* [TLR] signaling in murine bone marrow derived macrophages ( BMM Phis ) and in vivo . Regulation TLR7 LYN 20385881 2262056 The data suggest that the mediated negative *regulation* of [TLR] signaling proceeds , at least in part , via PI3K . Regulation TLR7 MAP3K7 21335610 2443366 In this study , we sought to determine the *role* of the MAP3K in cytokine and [TLR] mediated signalling . Regulation TLR7 MAP3K7 24277938 2898460 Here , we show that ribosomal S6 kinase 1 ( S6K1 ) negatively *regulates* [TLR] mediated signals by inhibiting activity . Regulation TLR7 MAPK1 22109714 2568199 The regulatory effect of complement on [TLR] signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased and nuclear factor ?B activation . Regulation TLR7 MAPK10 22109714 2568200 The regulatory effect of complement on [TLR] signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased and nuclear factor ?B activation . Regulation TLR7 MAPK11 22109714 2568201 The regulatory effect of complement on [TLR] signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased and nuclear factor ?B activation . Regulation TLR7 MAPK12 22109714 2568202 The regulatory effect of complement on [TLR] signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased and nuclear factor ?B activation . Regulation TLR7 MAPK13 22109714 2568203 The regulatory effect of complement on [TLR] signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased and nuclear factor ?B activation . Regulation TLR7 MAPK14 22109714 2568204 The regulatory effect of complement on [TLR] signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased and nuclear factor ?B activation . Regulation TLR7 MAPK15 22109714 2568198 The regulatory effect of complement on [TLR] signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased and nuclear factor ?B activation . Regulation TLR7 MAPK3 22109714 2568205 The regulatory effect of complement on [TLR] signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased and nuclear factor ?B activation . Regulation TLR7 MAPK4 22109714 2568206 The regulatory effect of complement on [TLR] signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased and nuclear factor ?B activation . Regulation TLR7 MAPK6 22109714 2568207 The regulatory effect of complement on [TLR] signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased and nuclear factor ?B activation . Regulation TLR7 MAPK7 22109714 2568208 The regulatory effect of complement on [TLR] signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased and nuclear factor ?B activation . Regulation TLR7 MAPK8 22109714 2568209 The regulatory effect of complement on [TLR] signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased and nuclear factor ?B activation . Regulation TLR7 MAPK9 22109714 2568210 The regulatory effect of complement on [TLR] signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and *involved* increased and nuclear factor ?B activation . Regulation TLR7 MARCH1 24600555 2886395 Here , we have addressed the *effect* of Tollip and on the regulation of MHC II trafficking and [TLR] signaling . Regulation TLR7 MSH2 22564632 2596403 To test the *effect* of on [TLR] regulation , we first isolated pancreatic islets from rats pretreated with/without a-MSH and assayed inflammatory cytokines and insulin release , and measured the expression of TLRs . Regulation TLR7 MSH3 22564632 2596404 To test the *effect* of on [TLR] regulation , we first isolated pancreatic islets from rats pretreated with/without a-MSH and assayed inflammatory cytokines and insulin release , and measured the expression of TLRs . Regulation TLR7 MSH4 22564632 2596405 To test the *effect* of on [TLR] regulation , we first isolated pancreatic islets from rats pretreated with/without a-MSH and assayed inflammatory cytokines and insulin release , and measured the expression of TLRs . Regulation TLR7 MSH5 22564632 2596406 To test the *effect* of on [TLR] regulation , we first isolated pancreatic islets from rats pretreated with/without a-MSH and assayed inflammatory cytokines and insulin release , and measured the expression of TLRs . Regulation TLR7 MSH6 22564632 2596407 To test the *effect* of on [TLR] regulation , we first isolated pancreatic islets from rats pretreated with/without a-MSH and assayed inflammatory cytokines and insulin release , and measured the expression of TLRs . Regulation TLR7 MUC1 24693944 2949301 In the present study , we determined whether *regulates* MyD88 independent [TLR] signaling mediated through the TLR3-Toll/IL-1 receptor-domain containing adapter inducing IFN-ß ( TRIF ) pathway in response to poly ( I:C ) . Regulation TLR7 MYD88 16272344 1479478 is *involved* in [TLR] , but also in IL-1R associated kinase 1-mediated IL-1R and -18R signaling . Regulation TLR7 MYD88 19050243 1999299 ZAP70 is induced via activation of [TLR-7] or -9 in a *dependent* manner , depends on protein kinase B (PKB)/mammalian target of rapamycin signaling and is rapamycin sensitive . Regulation TLR7 MYD88 19950169 2203999 Herein , we demonstrate that PKC-alpha is induced by several *dependent* [TLR/IL-1R] ligands and regulates cytokine expression in human and murine DC . Regulation TLR7 MYD88 20452828 2282935 We hypothesized that *dependent* [TLR] signaling at intestinal epithelium is critical for mucosal immune homeostasis . Regulation TLR7 MYD88 21047782 2357668 however , after activation of these cells with *dependent* [TLR] ligands , MHC-II ubiquitination is blocked , and MHC-II survival is prolonged . Regulation TLR7 MYD88 21918197 2491997 Combination of anti-CD180 with various *dependent* [TLR] ligands biased B cell fate because coinjection diminished Ig production , but purified B cells exhibited synergistic proliferation . Regulation TLR7 MYD88 21918197 2492020 Thus , CD180 stimulation induces intrinsic B cell proliferation and differentiation , causing rapid increases in IgG , and integrates *dependent* [TLR] signals to regulate proliferation , cytokine production , and differentiation . Regulation TLR7 MYD88 22837203 2671083 *dependent* [toll-like receptor 7] signaling mediates protection from severe Ross River virus induced disease in mice . Regulation TLR7 MYD88 23490990 2782095 Given the central *role* of in [TLR/IL-1R] signaling , we set out different strategies to develop drugs that can block its function . Regulation TLR7 MYLIP 18791161 1986400 We found that , a negative *regulator* of [Toll-like receptor (TLR)] signaling , was decreased in freshly isolated splenic lymphocytes from estrogen treated mice compared with placebo controls . Regulation TLR7 MYLIP 23794009 2909229 We propose a *role* for in [TLR] signalling through a negative feedback mechanism involving the attenuation of NF-?B by down-regulation of IRAK-1 and TRAF-6 . Regulation TLR7 MYLIP 24014244 2856827 Here , we investigated the *role* of in [TLR] pathway regulation in human pDCs . Regulation TLR7 NDP 21964925 2556878 Furthermore , although A20 is known as a signaling fine-tuner to prevent excess TLR signaling , it paradoxically downregulates the fine tuning *effect* of on [TLR] signaling . Regulation TLR7 NELFCD 18377768 1888560 [TLR] stimulation *controls* , Th2 , and Th17 cell differentiation , cytokine production in mast cells , and activation of eosinophils via direct and indirect pathways . Regulation TLR7 NELFCD 20309865 2281705 Expression of Toll-like receptor 3 and [Toll-like receptor 7] in muscle is characteristic of inflammatory myopathy and is differentially *regulated* by and Th17 cytokines . Regulation TLR7 NELFCD 21555403 2445041 To the best of our knowledge , this study provides the first evidence that TREM-1 functions as an inflammatory amplifier in P. aeruginosa keratitis by modulating [TLR] signaling and *responses* . Regulation TLR7 NEU1 20864924 2326088 It suggests that ligand induced [TLR] activation is tightly *controlled* by Neu1 activation . Regulation TLR7 NEU2 20864924 2326089 It suggests that ligand induced [TLR] activation is tightly *controlled* by Neu1 activation . Regulation TLR7 NEU3 20864924 2326090 It suggests that ligand induced [TLR] activation is tightly *controlled* by Neu1 activation . Regulation TLR7 NEU4 20864924 2326087 It suggests that ligand induced [TLR] activation is tightly *controlled* by Neu1 activation . Regulation TLR7 NFKB1 15499080 1367069 [TLR] signaling in CEC did not *involve* ( p65 ) activation with the inhibitory p50 form of NF-kappaB predominating in CEC in both the healthy and inflamed colon . Regulation TLR7 NGF 19844589 2155567 The different induced [TLR] *response* between VKC and healthy-control conjunctival ECs as well as the different cytokine response might reflect a different pattern of cell activation according to the state of VKC . Regulation TLR7 NGF 24585880 2924938 binding to TrkA *affects* [TLR] signaling , favoring pathways that mediate inhibition of inflammatory responses : it increases Akt phosphorylation , inhibits glycogen synthase kinase 3 activity , reduces I?B phosphorylation and p65 NF-?B translocation , and increases nuclear p50 NF-?B binding activity . Regulation TLR7 NOS1 21876038 2486714 [TLR] regulation of SPSB1 *controls* inducible induction . Regulation TLR7 NOS2 21876038 2486715 [TLR] regulation of SPSB1 *controls* inducible induction . Regulation TLR7 NOS3 21876038 2486716 [TLR] regulation of SPSB1 *controls* inducible induction . Regulation TLR7 NOX1 18779779 1986012 We investigated the potential *role* of the on vascular [Toll-like receptor (TLR)] expression and carotid neointimal formation in high-fat ( HF ) diet induced obesity (DIO) model . Regulation TLR7 NOX3 18779779 1986013 We investigated the potential *role* of the on vascular [Toll-like receptor (TLR)] expression and carotid neointimal formation in high-fat ( HF ) diet induced obesity (DIO) model . Regulation TLR7 NOX4 18779779 1986014 We investigated the potential *role* of the on vascular [Toll-like receptor (TLR)] expression and carotid neointimal formation in high-fat ( HF ) diet induced obesity (DIO) model . Regulation TLR7 NOX5 18779779 1986011 We investigated the potential *role* of the on vascular [Toll-like receptor (TLR)] expression and carotid neointimal formation in high-fat ( HF ) diet induced obesity (DIO) model . Regulation TLR7 NPR2 23818205 2808312 CNP and showed different characteristic on renal cortex at different pathological period in diabetes rats , and [TLR] *regulated* their expression . Regulation TLR7 NRAS 17045653 1666649 The results demonstrate that for the first time that the small GTPase is *involved* in [TLR] signaling of avian heterophils with the TLR agonists LPS ( Ras ) and FLG ( Rap1 ) inducing differential signaling cascades to activate the downstream ERK MAP kinase . Regulation TLR7 NRAS 21665146 2442706 Whereas GPCRs activate p110? in a Ras/p101 dependent manner , RTKs and [TLR/IL1Rs] directly activate p110? in a *dependent* manner . Regulation TLR7 NTRK1 24585880 2924939 NGF binding to *affects* [TLR] signaling , favoring pathways that mediate inhibition of inflammatory responses : it increases Akt phosphorylation , inhibits glycogen synthase kinase 3 activity , reduces I?B phosphorylation and p65 NF-?B translocation , and increases nuclear p50 NF-?B binding activity . Regulation TLR7 OTUD5 22685311 2621031 Leishmania donovani exploits host , a negative *regulator* of [TLR] signaling , to subvert host immune response . Regulation TLR7 PAF1 19843712 2196544 The *involvement* of leukotriene (LT) B ( 4 ) and in [TLR] ligand induced activation of inflammatory cell functions is essentially unknown . Regulation TLR7 PAM 20303182 2273069 The aim of the present study was to gain better insight into the nature of the ligand for TLR15 by characterizing gene expression patterns of [TLR15] by heterophils in *response* to numerous bacterial derived TLR agonists LPS , flagellin , CpG oligodeoxynucleotides , lipotechoic acid (LTA) , peptidoglycan ( PGN ) , and , stimulation with live Salmonella enterica serovar Enteritidis ( SE-used as a positive control ) , chicken isolates of Escherichia coli ( EC ) and Enterococcus gallinarum ( EG ) , the equine-specific pathogen Rhodococcus equi , and stimulation with heat killed , and formalin killed SE , EC , and EG . Regulation TLR7 PELI1 23603814 2778718 Notably , *regulates* [Toll-like receptor (TLR)] pathway signaling by promoting degradation of TNF receptor associated factor 3 (Traf3) , a potent inhibitor of mitogen activated protein kinase (MAPK) activation and gene induction . Regulation TLR7 PI3 16474002 1548333 A number of previous studies have suggested the *involvement* of in [Toll-like receptor (TLR)] signaling . Regulation TLR7 PIK3CA 12860525 1111543 and negative *regulation* of [TLR] signaling . Regulation TLR7 PIK3CA 25015834 2953002 However , the mechanisms by which negatively *regulates* [TLR] signaling are only partially resolved . Regulation TLR7 PIK3R1 12860525 1111544 and negative *regulation* of [TLR] signaling . Regulation TLR7 PIK3R1 25015834 2953003 However , the mechanisms by which negatively *regulates* [TLR] signaling are only partially resolved . Regulation TLR7 PTBP1 18403023 1913606 We have analyzed the expression of 10 TLR genes relative to validated reference genes at predilection sites in ileum , jejunum and associated lymph nodes as well as in peripheral blood , to determine if [TLR] expression is altered in *response* to infection with M . in outbred sheep . Regulation TLR7 QRICH1 18367379 1906504 Because no research has been published to date on the *effect* of on [TLR] receptors in critical patients , it was determined in an initial sample of 30 patients . Regulation TLR7 QRICH2 18367379 1906505 Because no research has been published to date on the *effect* of on [TLR] receptors in critical patients , it was determined in an initial sample of 30 patients . Regulation TLR7 RBBP4 23853092 2834871 A hypoxia-inducible factor (HIF) 1 binding site in this promoter was required for *dependent* [TLR-inducible] promoter activity and for Hdac7- and HIF-1a mediated trans-activation . Regulation TLR7 RBBP7 23853092 2834872 A hypoxia-inducible factor (HIF) 1 binding site in this promoter was required for *dependent* [TLR-inducible] promoter activity and for Hdac7- and HIF-1a mediated trans-activation . Regulation TLR7 RELA 15499080 1367070 [TLR] signaling in CEC did not *involve* ( p65 ) activation with the inhibitory p50 form of NF-kappaB predominating in CEC in both the healthy and inflamed colon . Regulation TLR7 RIPK1 24808358 2939824 Uncontrolled [TLR] activation in a *dependent* manner is responsible for the enhanced functionality of caspase-8-deficient DCs , because deletion of the TLR signaling mediator , MyD88 , ameliorates systemic autoimmunity induced by caspase-8 deficiency . Regulation TLR7 RPS6KA1 24277938 2898459 Here , we show that ( S6K1 ) negatively *regulates* [TLR] mediated signals by inhibiting TAK1 activity . Regulation TLR7 S100A12 17579082 1763905 Negative *regulation* of [TLR] responses by the neuropeptide is mediated by the transcriptional repressor ICER . Regulation TLR7 SEA 15585871 1345834 In contrast , the *effects* of on [TLR] ligand induced DC activation were striking : when mixed with LPS , SEA significantly affects the expression of > 100 LPS regulated genes . Regulation TLR7 SETD2 23853092 2834922 Thus , Hdac7-u positively regulates *dependent* [TLR] signaling in macrophages , whereas an interaction with CtBP1 likely prevents Hdac7-s from exerting this effect . Regulation TLR7 SFTPA1 18523248 1922724 Pulmonary *regulates* [TLR] expression and activity in human macrophages . Regulation TLR7 SFTPA2 18523248 1922725 Pulmonary *regulates* [TLR] expression and activity in human macrophages . Regulation TLR7 SIGIRR 18322211 1881218 In this study , we tested the hypothesis that Ig IL-1 related receptor , a member of the IL-1R family acting as a negative regulator of TLR/IL-1R signaling , *affects* [TLR] responses in fungal infections . Regulation TLR7 SIGIRR 20112371 2219504 BB loop deletion was sufficient to completely abrogate 's inhibitory *effect* on [TLR7] signalling . Regulation TLR7 SIGIRR 20130217 2213359 In this study , we investigated the *role* of in regulating epithelial-specific [TLR] responses and characterized its expression in colonic biopsy specimens . Regulation TLR7 SIGIRR 23950714 2831583 One reason for the innate hypo-responsiveness of IEC is their expression of , a negative *regulator* of interleukin (IL)-1 and [TLR] signaling . Regulation TLR7 SOCS1 22547696 2603001 did not modulate Dectin-1 signaling but *affected* [TLR] signaling , leading to decreased and abbreviated NF-?B activation in BMMs triggered by TLR9 . Regulation TLR7 SOCS2 22291912 2545524 Recent studies suggest that is *involved* in the regulation of [TLR] signaling . Regulation TLR7 SRR 18355244 1957950 We investigated the *effects* of on [TLR] responses in primary human monocytes and monocyte derived macrophages (MDM) . Regulation TLR7 STAT1 17785783 1790621 Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells : alternatively activated negatively *regulates* [TLR] signaling in macrophages . Regulation TLR7 SULT2A1 16000329 1434865 While pre-treatment with MALP-2 does not involve differential expression of TLR and IL-1R associated kinase proteins , , a negative *regulator* of [TLR] signaling , was up-regulated after treatment of mice with either MALP-2 or N-alpha-palmitoyl-S-[2,3-bis ( palmitoyloxy ) - ( 2RS ) -propyl ] -L-cysteine . Regulation TLR7 SYK 20138367 2227225 Herein , we investigated the *role* of in [TLR] mediated signaling and gene regulation . Regulation TLR7 TBK1 22945920 2678626 *plays* an essential role in [Toll-like receptor (TLR)-] and retinoic acid-inducible gene I (RIG-I) mediated induction of type I interferon ( IFN ; Regulation TLR7 TGFB1 17920684 1844074 Endogenous ( TGF-beta1 ) *plays* an important role in the negative regulation of [toll-like receptor (TLR)] signaling in a feedback manner . Regulation TLR7 TGFB1 20171181 2228754 Smad7 and Smad6 bind to discrete regions of Pellino-1 via their MH2 domains to mediate induced negative *regulation* of [IL-1R/TLR] signaling . Regulation TLR7 TIRAP 24529375 2914932 Here , we report that , in response to natural activators of innate immunity , the sorting adaptor *regulates* [TLR] signaling from the plasma membrane and endosomes . Regulation TLR7 TLR2 18780723 1975894 Consequently , [TLR] *responses* to whole bacteria as well as to , 4 and 9 ligands are impaired . Regulation TLR7 TLR2 22126103 2542226 L. plantarum genomic DNA mediated inhibition of signaling pathway and tumor necrosis factor-alpha was accompanied by the suppression of , TLR4 , and TLR9 and the induction of interleukin-1 receptor associated kinase M , a negative *regulator* of [TLR] . Regulation TLR7 TLR3 23232980 2786110 These findings demonstrate that activation differentially *regulates* [TLR] expression through autocrine signaling involving IL-6 secretion , IL-6Ra activation and subsequent phosphorylation of Stat3 . Regulation TLR7 TLR4 22126103 2542227 L. plantarum genomic DNA mediated inhibition of signaling pathway and tumor necrosis factor-alpha was accompanied by the suppression of toll-like receptor (TLR) 2 , , and TLR9 and the induction of interleukin-1 receptor associated kinase M , a negative *regulator* of [TLR] . Regulation TLR7 TLR8 20811154 2330685 These data provide evidence for a pivotal *role* for mouse in the regulation of mouse [TLR7] expression and prevention of spontaneous autoimmunity . Regulation TLR7 TLR9 20089701 2206070 *regulates* [TLR7-] and MyD88 dependent autoantibody production and disease in a murine model of lupus . Regulation TLR7 TLR9 22126103 2542228 L. plantarum genomic DNA mediated inhibition of signaling pathway and tumor necrosis factor-alpha was accompanied by the suppression of toll-like receptor (TLR) 2 , TLR4 , and and the induction of interleukin-1 receptor associated kinase M , a negative *regulator* of [TLR] . Regulation TLR7 TLR9 22434514 2624436 Data from mouse models suggest a pathogenic role for [TLR7] and a protective *role* for in the pathogenesis of SLE . Regulation TLR7 TNFAIP3 19912257 2189924 Several negative regulatory mechanisms control Toll-like receptor (TLR) mediated inflammatory responses and restore immune system balance , including the , a negative *regulator* of [TLR] signalling that inhibits nuclear factor kappa B (NF-kappaB) activity . Regulation TLR7 TOLLIP 11751856 916062 Negative *regulation* of [TLR] signaling by may therefore serve to limit the production of proinflammatory mediators during inflammation and infection . Regulation TLR7 TOLLIP 20511545 2276892 Interestingly , EGCG induced a rapid upregulation of , a negative *regulator* of [TLR] signaling , and this EGCG action was prevented by 67LR silencing or anti-67LR Ab treatment . Regulation TLR7 TOLLIP 21320497 2398897 Silencing of , a negative *regulator* of [TLR] signaling impaired the TLR2 signaling inhibitory activity of EGCG , suggesting that TLR2 response could be inhibited by EGCG via 67LR and Tollip . Regulation TLR7 TOLLIP 23353651 2747655 Quercetin markedly elevated the expression of the , a negative *regulator* of [TLR] signaling . Regulation TLR7 TOLLIP 24600555 2886394 Here , we have addressed the *effect* of and MARCH1 on the regulation of MHC II trafficking and [TLR] signaling . Regulation TLR7 TP53 23150340 2717963 Activation of p53 by common antitumor agents results in dependent *regulation* of expression of most [TLR] genes in human primary and cancer cell lines , resulting in modulation of TLR downstream responses to cognate ligands . Regulation TLR7 TP53 23150340 2717973 In addition several tumor associated mutants can also *affect* [TLR] gene expression . Regulation TLR7 TRAF1 24058413 2846525 An increase in ( [TLR] negative *regulator* ) mRNA was observed after oligo-HA treatment of WT but not in Tlr4-/- macrophages , and oligo-HA did not suppress cytokine responsiveness in Traf1-/- macrophages . Regulation TLR7 TRAF3 21971520 2512693 Thus , *plays* varied and cell type-specific , biological roles in [TLR] responses . Regulation TLR7 TRAF3 23603814 2778717 Notably , Peli1 *regulates* [Toll-like receptor (TLR)] pathway signaling by promoting degradation of , a potent inhibitor of mitogen activated protein kinase (MAPK) activation and gene induction . Regulation TLR7 TRAF5 24259503 2892720 negatively *regulates* [TLR] signaling in B lymphocytes . Regulation TLR7 TRAF5 24259503 2892760 negatively *regulated* [TLR] signaling in a cell-specific manner , because TRAF5 ( -/- ) macrophages and dendritic cells showed less dramatic differences in TLR mediated cytokine production than B cells . Regulation TLR7 TREM2 23459077 2776463 Depending on the cell type , activation *plays* an important role in activation and differentiation of osteoclasts , phagocytosis of bacteria , brain and bone homeostasis and inhibition of the [toll-like receptor (TLR)] signaling in macrophages and dendritic cells . Regulation TLR7 UNC93B1 21683627 2455510 Thus , *controls* homeostatic [TLR7] activation by balancing TLR9 to TLR7 trafficking . Regulation TLR7 USP4 22262844 2617374 Taken together , our results demonstrate that *plays* an essential role in negative regulation of the [TLR/IL-1R] signaling mediated innate immune response . Regulation TLR7 VIP 22661083 2615416 In vitro studies assessed the *effects* of on [TLR] regulation in macrophages and Langerhans cells . Regulation TLR7 WDR61 19843712 2196545 The *involvement* of leukotriene (LT) B ( 4 ) and in [TLR] ligand induced activation of inflammatory cell functions is essentially unknown . Regulation TLR7 ZC3H12D 22036805 2527493 We here report that negatively *regulates* [TLR] signaling and macrophage activation . Regulation TLR8 CCL17 18557811 1972059 These results suggest that the CCL17 produced by HGFs may be involved in the migration of Th2 cells into inflamed tissues , and provide evidence that production is *controlled* by cytokines and [TLR] ligands in periodontal disease . Regulation TLR8 TNF 21947541 2546885 In conclusion , we report gender-specific associations with TLR7 and [TLR8] polymorphisms and cellular *responses* to its ligand . Regulation TLR9 CCL17 18557811 1972060 These results suggest that the CCL17 produced by HGFs may be involved in the migration of Th2 cells into inflamed tissues , and provide evidence that production is *controlled* by cytokines and [TLR] ligands in periodontal disease . Regulation TLR9 TLR7 22434514 2624437 Data from mouse models suggest a pathogenic role for and a protective *role* for [TLR9] in the pathogenesis of SLE . Regulation TMBIM1 FAS 21107705 2383505 Only high but not constitutive level of [PP1201] *controls* signaling . Regulation TMED7 CCND1 24178620 2896973 Immunoprecipitation analyses and siRNA assays suggested a direct *role* of in the regulation of [p27] ( KIP1 ) levels . Regulation TMED7 EPHB2 21840777 2485996 In the present study , shRNA against cathepsin B and uPAR as well as specific inhibitors , Wortmannin ( 10 µM ) and U0126 ( 10 µM ) , were used to determine the *roles* of AKT and signaling on [p27] expression . Regulation TMED7 EPHB2 21840777 2486001 Immunoblot analysis demonstrated that downregulation of both and p-AKT downstream of EGFR and ß1 integrin are *involved* in the [p27] upregulation . Regulation TMED7 FOXO1 17015685 1629789 Consistent with the important *role* of in [p27] kip1 transcription , stimulated Vav1 ( -/- ) T cells failed to down-regulate the expression of p27 kip1 , explaining their G0-G1 arrest . Regulation TMED7 ID1 18456300 1921353 Neither nor Id3 was sufficient to transform Rat-1 cells and inhibition of Id1 expression did not *affect* LMP1 induced morphologic transformation of Rat-1 cells or reduction of [p27] . Regulation TMED7 IFI27 10022731 590133 These findings suggest that [p27] expression is regulated negatively by androgens and that increased expression of in CWR22 xenografts may be *involved* in the suppression of proliferation following castration . Regulation TMED7 IFI27 19556892 2117175 In addition , inhibition of threonine-187 phosphorylation of ( kip1 ) protein for ubiquitinyl-proteasomal mediated degradation was also *involved* in upregulation of [p27] ( kip1 ) . Regulation TMEM100 CAPN1 2831893 88215 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM100 CAPN10 2831893 88216 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM100 CAPN11 2831893 88217 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM100 CAPN12 2831893 88214 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM100 CAPN13 2831893 88225 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM100 CAPN14 2831893 88226 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM100 CAPN15 2831893 88213 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM100 CAPN2 2831893 88218 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM100 CAPN3 2831893 88219 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM100 CAPN5 2831893 88220 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM100 CAPN6 2831893 88221 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM100 CAPN7 2831893 88222 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM100 CAPN8 2831893 88223 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM100 CAPN9 2831893 88224 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM100 CD28 21257960 2387105 Current dogma suggests that most , if not all , [Tmem] responses are *independent* of the requirement for and/or CD154/CD40 mediated costimulation to mount a recall response . Regulation TMEM100 CD40 21257960 2387103 Current dogma suggests that most , if not all , [Tmem] responses are *independent* of the requirement for CD28 and/or mediated costimulation to mount a recall response . Regulation TMEM100 CD40LG 21257960 2387104 Current dogma suggests that most , if not all , [Tmem] responses are *independent* of the requirement for CD28 and/or mediated costimulation to mount a recall response . Regulation TMEM100 FXYD1 21220422 2408584 Na/K-ATPase ( NKA ) activity is dynamically *regulated* by an inhibitory interaction with a small [transmembrane protein] , . Regulation TMEM100 KLC1 22404616 2593716 An artificial [transmembrane protein] containing either WD motif induced kinesin-1 's vesicular association and anterograde transport in a *dependent* manner , even in the normally inhibiting presence of excess KLC1 , thus allowing us to analyze the KLC1 TPR-WD functional interaction in detail in vivo . Regulation TMEM100 KLC2 22404616 2593713 An artificial [transmembrane protein] containing either WD motif induced kinesin-1 's vesicular association and anterograde transport in a *dependent* manner , even in the normally inhibiting presence of excess KLC1 , thus allowing us to analyze the KLC1 TPR-WD functional interaction in detail in vivo . Regulation TMEM100 KLC3 22404616 2593714 An artificial [transmembrane protein] containing either WD motif induced kinesin-1 's vesicular association and anterograde transport in a *dependent* manner , even in the normally inhibiting presence of excess KLC1 , thus allowing us to analyze the KLC1 TPR-WD functional interaction in detail in vivo . Regulation TMEM100 KLC4 22404616 2593715 An artificial [transmembrane protein] containing either WD motif induced kinesin-1 's vesicular association and anterograde transport in a *dependent* manner , even in the normally inhibiting presence of excess KLC1 , thus allowing us to analyze the KLC1 TPR-WD functional interaction in detail in vivo . Regulation TMEM100 RUNX1 11396961 823642 A hematopoietic-specific [transmembrane protein] , Art-1 , is possibly *regulated* by . Regulation TMEM100 STAT6 17855502 1823389 Furthermore , we found that IL-4 induced expression of E-cadherin and dendritic cell-specific [transmembrane protein] in a *dependent* manner . Regulation TMEM101 CAPN8 2831893 89147 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM102 CAPN8 2831893 88629 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM104 CAPN8 2831893 88349 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM105 CAPN8 2831893 88657 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM107 CAPN8 2831893 88867 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM108 CAPN8 2831893 89049 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM109 CAPN8 2831893 89175 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM11 CAPN8 2831893 87551 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM110 CAPN8 2831893 89343 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM114 CAPN8 2831893 89539 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM115 CAPN8 2831893 89259 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM116 CAPN8 2831893 87943 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM117 CAPN8 2831893 88055 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM119 CAPN8 2831893 88783 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM121 CAPN8 2831893 87691 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM123 CAPN8 2831893 89287 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM125 CAPN8 2831893 88979 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM127 CAPN8 2831893 88363 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM128 CAPN8 2831893 88937 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM129 CAPN8 2831893 87985 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM130 CAPN8 2831893 88097 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM131 CAPN8 2831893 89315 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM133 CAPN8 2831893 87859 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM134 CAPN8 2831893 88405 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM135 CAPN8 2831893 88419 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM136 CAPN8 2831893 88993 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM138 CAPN8 2831893 88685 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM139 CAPN8 2831893 87817 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM140 CAPN8 2831893 87775 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM141 CAPN8 2831893 88951 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM143 CAPN8 2831893 88195 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM144 CAPN8 2831893 88265 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM145 CAPN8 2831893 88671 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM147 CAPN8 2831893 89329 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM154 CAPN8 2831893 88559 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM155 CAPN8 2831893 88531 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM156 CAPN1 2831893 88467 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM156 CAPN10 2831893 88468 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM156 CAPN11 2831893 88469 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM156 CAPN12 2831893 88466 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM156 CAPN13 2831893 88477 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM156 CAPN14 2831893 88478 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM156 CAPN15 2831893 88465 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM156 CAPN2 2831893 88470 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM156 CAPN3 2831893 88471 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM156 CAPN5 2831893 88472 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM156 CAPN6 2831893 88473 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM156 CAPN7 2831893 88474 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM156 CAPN8 2831893 88475 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM156 CAPN9 2831893 88476 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM156 CD28 21257960 2387159 Current dogma suggests that most , if not all , [Tmem] responses are *independent* of the requirement for and/or CD154/CD40 mediated costimulation to mount a recall response . Regulation TMEM156 CD40 21257960 2387157 Current dogma suggests that most , if not all , [Tmem] responses are *independent* of the requirement for CD28 and/or mediated costimulation to mount a recall response . Regulation TMEM156 CD40LG 21257960 2387158 Current dogma suggests that most , if not all , [Tmem] responses are *independent* of the requirement for CD28 and/or mediated costimulation to mount a recall response . Regulation TMEM156 FXYD1 21220422 2408602 Na/K-ATPase ( NKA ) activity is dynamically *regulated* by an inhibitory interaction with a small [transmembrane protein] , . Regulation TMEM156 KLC1 22404616 2593788 An artificial [transmembrane protein] containing either WD motif induced kinesin-1 's vesicular association and anterograde transport in a *dependent* manner , even in the normally inhibiting presence of excess KLC1 , thus allowing us to analyze the KLC1 TPR-WD functional interaction in detail in vivo . Regulation TMEM156 KLC2 22404616 2593785 An artificial [transmembrane protein] containing either WD motif induced kinesin-1 's vesicular association and anterograde transport in a *dependent* manner , even in the normally inhibiting presence of excess KLC1 , thus allowing us to analyze the KLC1 TPR-WD functional interaction in detail in vivo . Regulation TMEM156 KLC3 22404616 2593786 An artificial [transmembrane protein] containing either WD motif induced kinesin-1 's vesicular association and anterograde transport in a *dependent* manner , even in the normally inhibiting presence of excess KLC1 , thus allowing us to analyze the KLC1 TPR-WD functional interaction in detail in vivo . Regulation TMEM156 KLC4 22404616 2593787 An artificial [transmembrane protein] containing either WD motif induced kinesin-1 's vesicular association and anterograde transport in a *dependent* manner , even in the normally inhibiting presence of excess KLC1 , thus allowing us to analyze the KLC1 TPR-WD functional interaction in detail in vivo . Regulation TMEM156 RUNX1 11396961 823660 A hematopoietic-specific [transmembrane protein] , Art-1 , is possibly *regulated* by . Regulation TMEM156 STAT6 17855502 1823407 Furthermore , we found that IL-4 induced expression of E-cadherin and dendritic cell-specific [transmembrane protein] in a *dependent* manner . Regulation TMEM158 CAPN8 2831893 89301 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM159 CAPN8 2831893 89273 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM160 CAPN8 2831893 88377 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM163 CAPN8 2831893 88083 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM164 CAPN8 2831893 88461 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM165 CAPN8 2831893 89371 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM168 CAPN8 2831893 88293 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM169 CAPN8 2831893 87971 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM17 CAPN8 2831893 88615 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM171 CAPN8 2831893 88699 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM173 CAPN8 2831893 88825 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM174 CAPN8 2831893 88909 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM175 CAPN8 2831893 89161 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM177 CAPN8 2831893 88881 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM179 CAPN8 2831893 87649 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM18 CAPN8 2831893 88041 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM180 CAPN8 2831893 88447 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM181 CAPN8 2831893 87705 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM182 CAPN8 2831893 88503 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM186 CAPN8 2831893 87901 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM187 CAPN8 2831893 85453 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM189 CAPN8 2831893 87537 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM19 CAPN8 2831893 88209 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM190 CAPN8 2831893 89245 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM192 CAPN8 2831893 88643 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM196 CAPN8 2831893 87831 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM198 CAPN8 2831893 89553 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM199 CAPN8 2831893 87593 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM2 CAPN8 2831893 85228 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM201 CAPN8 2831893 89581 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM202 CAPN8 2831893 89609 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM203 CAPN8 2831893 88965 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM204 CAPN8 2831893 85467 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM205 CAPN8 2831893 89231 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM206 CAPN8 2831893 88181 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM207 CAPN8 2831893 89567 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM208 CAPN8 2831893 87915 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM209 CAPN8 2831893 87789 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM210 CAPN8 2831893 89651 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM211 CAPN1 2831893 89587 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM211 CAPN10 2831893 89588 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM211 CAPN11 2831893 89589 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM211 CAPN12 2831893 89586 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM211 CAPN13 2831893 89597 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM211 CAPN14 2831893 89598 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM211 CAPN15 2831893 89585 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM211 CAPN2 2831893 89590 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM211 CAPN3 2831893 89591 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM211 CAPN5 2831893 89592 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM211 CAPN6 2831893 89593 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM211 CAPN7 2831893 89594 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM211 CAPN8 2831893 89595 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM211 CAPN9 2831893 89596 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM211 CD28 21257960 2387399 Current dogma suggests that most , if not all , [Tmem] responses are *independent* of the requirement for and/or CD154/CD40 mediated costimulation to mount a recall response . Regulation TMEM211 CD40 21257960 2387397 Current dogma suggests that most , if not all , [Tmem] responses are *independent* of the requirement for CD28 and/or mediated costimulation to mount a recall response . Regulation TMEM211 CD40LG 21257960 2387398 Current dogma suggests that most , if not all , [Tmem] responses are *independent* of the requirement for CD28 and/or mediated costimulation to mount a recall response . Regulation TMEM211 FXYD1 21220422 2408682 Na/K-ATPase ( NKA ) activity is dynamically *regulated* by an inhibitory interaction with a small [transmembrane protein] , . Regulation TMEM211 KLC1 22404616 2594108 An artificial [transmembrane protein] containing either WD motif induced kinesin-1 's vesicular association and anterograde transport in a *dependent* manner , even in the normally inhibiting presence of excess KLC1 , thus allowing us to analyze the KLC1 TPR-WD functional interaction in detail in vivo . Regulation TMEM211 KLC2 22404616 2594105 An artificial [transmembrane protein] containing either WD motif induced kinesin-1 's vesicular association and anterograde transport in a *dependent* manner , even in the normally inhibiting presence of excess KLC1 , thus allowing us to analyze the KLC1 TPR-WD functional interaction in detail in vivo . Regulation TMEM211 KLC3 22404616 2594106 An artificial [transmembrane protein] containing either WD motif induced kinesin-1 's vesicular association and anterograde transport in a *dependent* manner , even in the normally inhibiting presence of excess KLC1 , thus allowing us to analyze the KLC1 TPR-WD functional interaction in detail in vivo . Regulation TMEM211 KLC4 22404616 2594107 An artificial [transmembrane protein] containing either WD motif induced kinesin-1 's vesicular association and anterograde transport in a *dependent* manner , even in the normally inhibiting presence of excess KLC1 , thus allowing us to analyze the KLC1 TPR-WD functional interaction in detail in vivo . Regulation TMEM211 RUNX1 11396961 823740 A hematopoietic-specific [transmembrane protein] , Art-1 , is possibly *regulated* by . Regulation TMEM211 STAT6 17855502 1823487 Furthermore , we found that IL-4 induced expression of E-cadherin and dendritic cell-specific [transmembrane protein] in a *dependent* manner . Regulation TMEM212 CAPN8 2831893 89665 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM213 CAPN1 2831893 88705 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM213 CAPN10 2831893 88706 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM213 CAPN11 2831893 88707 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM213 CAPN12 2831893 88704 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM213 CAPN13 2831893 88715 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM213 CAPN14 2831893 88716 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM213 CAPN15 2831893 88703 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM213 CAPN2 2831893 88708 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM213 CAPN3 2831893 88709 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM213 CAPN5 2831893 88710 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM213 CAPN6 2831893 88711 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM213 CAPN7 2831893 88712 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM213 CAPN8 2831893 88713 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM213 CAPN9 2831893 88714 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM213 CD28 21257960 2387210 Current dogma suggests that most , if not all , [Tmem] responses are *independent* of the requirement for and/or CD154/CD40 mediated costimulation to mount a recall response . Regulation TMEM213 CD40 21257960 2387208 Current dogma suggests that most , if not all , [Tmem] responses are *independent* of the requirement for CD28 and/or mediated costimulation to mount a recall response . Regulation TMEM213 CD40LG 21257960 2387209 Current dogma suggests that most , if not all , [Tmem] responses are *independent* of the requirement for CD28 and/or mediated costimulation to mount a recall response . Regulation TMEM213 FXYD1 21220422 2408619 Na/K-ATPase ( NKA ) activity is dynamically *regulated* by an inhibitory interaction with a small [transmembrane protein] , . Regulation TMEM213 KLC1 22404616 2593856 An artificial [transmembrane protein] containing either WD motif induced kinesin-1 's vesicular association and anterograde transport in a *dependent* manner , even in the normally inhibiting presence of excess KLC1 , thus allowing us to analyze the KLC1 TPR-WD functional interaction in detail in vivo . Regulation TMEM213 KLC2 22404616 2593853 An artificial [transmembrane protein] containing either WD motif induced kinesin-1 's vesicular association and anterograde transport in a *dependent* manner , even in the normally inhibiting presence of excess KLC1 , thus allowing us to analyze the KLC1 TPR-WD functional interaction in detail in vivo . Regulation TMEM213 KLC3 22404616 2593854 An artificial [transmembrane protein] containing either WD motif induced kinesin-1 's vesicular association and anterograde transport in a *dependent* manner , even in the normally inhibiting presence of excess KLC1 , thus allowing us to analyze the KLC1 TPR-WD functional interaction in detail in vivo . Regulation TMEM213 KLC4 22404616 2593855 An artificial [transmembrane protein] containing either WD motif induced kinesin-1 's vesicular association and anterograde transport in a *dependent* manner , even in the normally inhibiting presence of excess KLC1 , thus allowing us to analyze the KLC1 TPR-WD functional interaction in detail in vivo . Regulation TMEM213 RUNX1 11396961 823677 A hematopoietic-specific [transmembrane protein] , Art-1 , is possibly *regulated* by . Regulation TMEM213 STAT6 17855502 1823424 Furthermore , we found that IL-4 induced expression of E-cadherin and dendritic cell-specific [transmembrane protein] in a *dependent* manner . Regulation TMEM214 CAPN8 2831893 88335 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM215 CAPN8 2831893 89637 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM216 CAPN8 2831893 87929 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM217 CAPN8 2831893 87719 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM218 CAPN8 2831893 88741 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM219 CAPN8 2831893 88013 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM220 CAPN8 2831893 89623 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM221 CAPN8 2831893 87803 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM222 CAPN8 2831893 88069 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM223 CAPN8 2831893 89063 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM225 CAPN8 2831893 89497 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM230 CAPN8 2831893 87185 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM231 CAPN8 2831893 89693 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM232 CAPN8 2831893 89707 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM233 CAPN8 2831893 89679 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM234 CAPN8 2831893 89203 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM235 CAPN8 2831893 88769 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM236 CAPN8 2831893 87845 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM237 CAPN8 2831893 85481 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM238 CAPN8 2831893 89721 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM239 CAPN8 2831893 89735 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM240 CAPN8 2831893 87999 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM241 CAPN8 2831893 89399 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM242 CAPN8 2831893 87579 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM243 CAPN8 2831893 87747 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM244 CAPN8 2831893 87733 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM245 CAPN8 2831893 85439 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM246 CAPN8 2831893 88895 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM247 CAPN8 2831893 89749 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM248 CAPN8 2831893 88125 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM249 CAPN8 2831893 89763 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM25 CAPN8 2831893 88321 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM251 CAPN8 2831893 87677 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM252 CAPN8 2831893 89091 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM253 CAPN8 2831893 89525 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM254 CAPN8 2831893 88279 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM256 CAPN8 2831893 89133 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM257 CAPN8 2831893 88237 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM258 CAPN8 2831893 85214 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM259 CAPN8 2831893 87565 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM26 CAPN8 2831893 89105 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM260 CAPN8 2831893 87663 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM261 CAPN8 2831893 89357 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM27 CAPN8 2831893 89217 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM31 CAPN8 2831893 89119 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM33 CAPN8 2831893 88153 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM35 CAPN8 2831893 88307 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM37 CAPN8 2831893 87607 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM40 CAPN8 2831893 88251 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM42 CAPN8 2831893 89035 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM43 CAPN8 2831893 89077 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM44 CAPN8 2831893 87957 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM47 CAPN8 2831893 87621 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM5 CAPN8 2831893 85425 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM51 CAPN8 2831893 88139 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM52 CAPN8 2831893 88811 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM53 CAPN8 2831893 88433 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM54 CAPN8 2831893 87873 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM56 CAPN8 2831893 88545 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM57 CAPN8 2831893 88167 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM59 CAPN8 2831893 85242 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM60 CAPN8 2831893 87761 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM61 CAPN8 2831893 88727 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM62 CAPN8 2831893 88489 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM64 CAPN8 2831893 88111 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM65 CAPN8 2831893 88027 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM66 CAPN8 2831893 89189 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM67 CAPN8 2831893 89021 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM68 CAPN8 2831893 88573 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM69 CAPN8 2831893 88839 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM70 CAPN8 2831893 88391 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM71 CAPN8 2831893 88587 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM72 CAPN8 2831893 89385 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM74 CAPN8 2831893 88517 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM75 CAPN8 2831893 89413 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM78 CAPN8 2831893 89427 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM79 CAPN8 2831893 88923 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM80 CAPN8 2831893 88755 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM81 CAPN8 2831893 89441 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM82 CAPN8 2831893 89455 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM88 CAPN8 2831893 89469 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM89 CAPN8 2831893 89483 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM9 CAPN8 2831893 87635 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM91 CAPN8 2831893 89511 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM92 CAPN8 2831893 88601 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM95 CAPN8 2831893 88797 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM97 CAPN8 2831893 88853 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM98 CAPN8 2831893 87887 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMEM99 CAPN8 2831893 89007 Our findings suggest that activity may *control* , both at a functional and at a structural level , the activity of this important [transmembrane protein] through the modulation of its susceptibility as a substrate of membrane bound protein kinase ( s ) . Regulation TMOD1 CA2 10096910 601486 *Role* of and cross-bridges in skeletal muscle [thin filament] activation probed with Ca2+ sensitizers . Regulation TMOD1 CA2 19209817 2007308 The smooth muscle-specific actin-bindingprotein caldesmon , together with calmodulin regulates the activity of the [thin filament] in *response* to . Regulation TMOD1 CA2 2142896 137560 Effect of thyroid status on [thin-filament] *regulation* and expression of troponin I in perinatal and adult rat hearts . Regulation TMOD1 CA2 2934055 53990 We propose that caldesmon based [thin-filament] *regulation* is a physiological mechanism in all smooth muscles . Regulation TMOD1 CA2 3167066 97563 Comparison of two types of *regulated* [thin filament] , reconstructed in ghost fibers by incorporating either caldesmon-gizzard tropomyosin-calmodulin or skeletal muscle troponin-tropomyosin complex , was performed by polarized microphotometry . Regulation TMOD1 CA2 7858135 287037 The similarity of activation dependence of VUS whether fibers were activated in a Ca ( 2+ ) -sensitive or -insensitive manners implies that VUS is determined by the average level of [thin filament] activation and that , with sTnC or cTnC , VUS is *affected* by binding to TnC only . Regulation TMOD1 CA2 8662805 365429 Exchange of beta- for alpha-tropomyosin in hearts of transgenic mice induces changes in [thin filament] *response* to , strong cross-bridge binding , and protein phosphorylation . Regulation TMOD1 CALD1 3595858 75533 Since the [thin filament] *regulation* of smooth muscle contraction by requires the presence of tropomyosin , these results suggest that the direct interaction between tropomyosin and caldesmon on the thin filament plays a role in this regulation . Regulation TMOD1 CALD1 8509369 221605 The essential role of tropomyosin in cooperative *regulation* of smooth muscle [thin filament] activity by . Regulation TMOD1 CALD1 9887964 558382 We have used this information to propose a structural mechanism for *regulation* of the smooth muscle [thin filament] . Regulation TMOD1 ELL 12414704 1011129 By blocking and depolymerization , [tropomodulin] *regulates* the architecture and the dynamics of the filament . Regulation TMOD1 HSPB1 20829522 2336606 We have examined the role of phosphorylation state ( s ) of HSP20 on mediated [thin-filament] *regulation* in CSMC . Regulation TMOD1 MYBPC1 20849827 2331342 *Effects* of cardiac on the regulation of interaction of cardiac myosin with [thin filament] in an in vitro motility assay . Regulation TMOD1 MYBPC2 20849827 2331343 *Effects* of cardiac on the regulation of interaction of cardiac myosin with [thin filament] in an in vitro motility assay . Regulation TMOD1 MYBPC3 20849827 2331344 *Effects* of cardiac on the regulation of interaction of cardiac myosin with [thin filament] in an in vitro motility assay . Regulation TMOD1 NEB 20176113 2242678 Various lines of evidence indicate that *plays* important roles in [thin filament] and Z-disc structure in skeletal muscle . Regulation TMOD1 RHO 24130935 2714745 Ethanol significantly inhibited thromboxane A2 mimetic induced contraction with intact endothelial function , but there was no relaxation on thromboxane A2 mimetic U-46619 induced contraction irrespective of endothelium suggesting that the pathway such as activation , Ca ( 2+ ) entry or [thin filament] *regulation* was not affected . Regulation TMOD1 TCEA1 12414704 1011128 By blocking and depolymerization , [tropomodulin] *regulates* the architecture and the dynamics of the filament . Regulation TMOD1 TPM1 14870966 1182553 The implications of these findings for the *role* of in [thin filament] regulation are discussed . Regulation TMOD1 TPM1 23662437 2714323 In striated muscle , the actin [thin filament] is *regulated* by the complex . Regulation TMOD1 TPM1 8509369 221601 The essential *role* of in cooperative regulation of smooth muscle [thin filament] activity by caldesmon . Regulation TMOD1 TPM2 14870966 1182554 The implications of these findings for the *role* of in [thin filament] regulation are discussed . Regulation TMOD1 TPM2 23662437 2714324 In striated muscle , the actin [thin filament] is *regulated* by the complex . Regulation TMOD1 TPM2 8509369 221602 The essential *role* of in cooperative regulation of smooth muscle [thin filament] activity by caldesmon . Regulation TMOD1 TPM3 14870966 1182555 The implications of these findings for the *role* of in [thin filament] regulation are discussed . Regulation TMOD1 TPM3 23662437 2714325 In striated muscle , the actin [thin filament] is *regulated* by the complex . Regulation TMOD1 TPM3 8509369 221603 The essential *role* of in cooperative regulation of smooth muscle [thin filament] activity by caldesmon . Regulation TMOD1 TPM4 14870966 1182556 The implications of these findings for the *role* of in [thin filament] regulation are discussed . Regulation TMOD1 TPM4 23662437 2714326 In striated muscle , the actin [thin filament] is *regulated* by the complex . Regulation TMOD1 TPM4 8509369 221604 The essential *role* of in cooperative regulation of smooth muscle [thin filament] activity by caldesmon . Regulation TMPRSS4 MORF4L1 23821596 2834519 Maintenance of interphase chromosome compaction and homolog pairing in Drosophila is *regulated* by the condensin [cap-h2] and its partner . Regulation TNC IL1B 18173448 1856034 *Effect* of hypoxia and on expression of [tenascin-C] in temporomandibular joint . Regulation TNC TNF 15592496 1375243 Since preinflammatory cytokines also act through p38MAPK and JNK signaling pathways , the possible *role* of in [tenascin-W] expression was also examined . Regulation TNC TNF 18061975 1853619 *Regulation* of [tenascin-C] expression by in cultured human osteoarthritis chondrocytes . Regulation TNC TNF 18061975 1853620 We investigated *regulation* of [tenascin-C] expression by through nuclear factor-alphaB ( NF-kappaB ) in OA cartilage in vivo and in vitro . Regulation TNC TNF 21205293 2379136 The expression of tenascin-C in the lungs of OVA challenged STAT4-/- mice was weaker than in those of OVA challenged WT and STAT6-/- mice suggesting that and IFN-? may *regulate* [tenascin-C] expression in vivo . Regulation TNF ACD 9386984 466439 These findings suggest that systemic [TNF alpha] or IL-1 beta are not involved in the erythropoietin *response* to . Regulation TNF ACE 23548129 2763209 *affects* the serum NO , [TNF-a] , and IL-1ß levels at the 5th hr after Carr injection . Regulation TNF ACE 9129996 426838 Therefore , in this study , we examined *effect* of inhibitors on [TNF-alpha] production both in vitro and in vivo by using human blood mononuclear cells and mice , respectively . Regulation TNF ACHE 18639629 2010677 Here we report that brain activity *controls* systemic and organ specific [TNF] production during endotoxemia . Regulation TNF ADAM17 11120787 758197 Hence , does not only *control* the release of [TNF-alpha] , but also that of sCD30 . Regulation TNF ADAM17 11508576 848153 Expression and function of tumor necrosis factor-alpha (TNF-alpha) converting enzyme ( TACE ) in synovia of patients with rheumatoid arthritis ( RA ) were examined to investigate posttranslational *regulation* of [TNF-alpha] production by in RA . Regulation TNF ADAM17 12658769 1030335 In order to investigate the effects of LPS on the gene transcription and expression and its regulating *effect* on the [TM-TNF] secretion , in vitro studies were carried out on HL-60 cells stimulated by LPS . Regulation TNF ADAM17 15206946 1261305 Therefore , *dependent* depletion of membrane bound [tumor necrosis factor] receptors from endothelial cells might constitute a mechanism of self-protection in states of prolonged immunostimulation . Regulation TNF ADAM17 15647744 1363627 In summary , these data show that IPC produces neuronal upregulation of and TNFR1 , and that the pathway [TACE/TNF-alpha/TNFR1/NF-kappaB] is *involved* in IT . Regulation TNF ADAM17 17786981 1842748 HDLs reduced the cholesterol and proteins ( including ADAM17 ) content of lipid rafts and triggered the *dependent* cleavage of [TNF] in the non-raft region of the membrane . Regulation TNF ADAM17 19082505 2018333 [TNF-alpha] production and the bioavailability of its receptors on the cell surface are *regulated* by ( TNF-alpha converting enzyme ) , a pleiotropic metalloprotease also known as ADAM17 , and its specific inhibitor TIMP3 . Regulation TNF ADAM17 19167455 2038618 Since is *involved* not only in degradation of cell-matrix adhesion structures , but also in ectodomain shedding of ligands for epidermal growth factor receptor (EGFR) and in release of [TNFalpha] , these results imply TACE mediated pathways as a new concept in HD toxicity . Regulation TNF ADAM17 19487969 2185520 Ron receptor tyrosine kinase negatively *regulates* [TNFalpha] production in alveolar macrophages by inhibiting NF-kappaB activity and production . Regulation TNF ADAM17 23639813 2805088 We conclude that *regulates* [TNF] , TNFR1 , and AR in the liver , and its expression in both hepatocytes and myeloid cells is important for TNF regulation after LPS injury or 2/3 PH , but is not required for liver regeneration . Regulation TNF ADAM8 20826683 2318787 Our results indicate an essential *role* for in modulating [TNF-alpha] signaling in CNS diseases : a feedback loop integrating TNF-alpha , ADAM8 , and TNF-R1 shedding as a plausible mechanism for TNF-alpha mediated neuroprotection in situ and a rationale for therapeutic intervention . Regulation TNF ADH4 20090911 2201597 Neither ethanol nor *affected* the expression of ANP , total pro-caspase-9 , cytosolic and total pro-caspase-8 , [TNF-alpha] , Fas receptor , Fas L and cytosolic AIF . Regulation TNF ADH5 20090911 2201598 Neither ethanol nor *affected* the expression of ANP , total pro-caspase-9 , cytosolic and total pro-caspase-8 , [TNF-alpha] , Fas receptor , Fas L and cytosolic AIF . Regulation TNF ADH6 20090911 2201599 Neither ethanol nor *affected* the expression of ANP , total pro-caspase-9 , cytosolic and total pro-caspase-8 , [TNF-alpha] , Fas receptor , Fas L and cytosolic AIF . Regulation TNF ADH7 20090911 2201600 Neither ethanol nor *affected* the expression of ANP , total pro-caspase-9 , cytosolic and total pro-caspase-8 , [TNF-alpha] , Fas receptor , Fas L and cytosolic AIF . Regulation TNF ADIPOQ 12974762 1139774 However , also negatively *regulates* [TNF-alpha] levels . Regulation TNF ADIPOQ 16155579 1461370 Dominant negative AMP activated protein kinase (AMPK) reversed the inhibitory *effects* of on apoptosis but had no effect on the suppressive effect of adiponectin on [TNF-alpha] production . Regulation TNF ADIPOQ 16310276 1518865 Of note , [TNF-alpha] levels were not *affected* by , whereas IL-10 production was increased . Regulation TNF ADIPOQ 20052772 2232476 Knockdown of IL-10 expression in primary cultures of Kupffer cells with small interfering RNA ( siRNA ) prevented the inhibitory *effect* of globular ( gAcrp ) on LPS stimulated [TNF-alpha] expression . Regulation TNF ADIPOQ 21626471 2454639 Full length *acted* differently on [TNF-a] and IL-6 production by upregulating TNF-a and IL-6 protein production , but not their mRNA expression . Regulation TNF ADIPOQ 22571939 2619225 Accumulative studies have shown that there exists a reciprocal relationship between adiponectin and TNF-a , i.e. , negatively *regulates* [TNF-a] expression , whereas adiponectin expression is inhibited by TNF-a . Regulation TNF ADORA1 11357956 815996 Previously , we have reported that the ( A1AR ) *regulates* [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-6 (IL-6) expression and exhibits diminished function in patients with multiple sclerosis ( MS ; Regulation TNF ADORA1 15748700 1379391 The *role* of and A2B receptors in the regulation of [TNF-alpha] production by human monocytes . Regulation TNF ADORA3 15748700 1379392 The *role* of and A2B receptors in the regulation of [TNF-alpha] production by human monocytes . Regulation TNF ADORA3 16324785 1519053 Thus , we investigated the *effect* of adenosine and ligands on LPS induced [tumor necrosis factor] ( TNF-alpha ) production and its molecular mechanism in mouse BV2 microglial cells . Regulation TNF ADRB2 11096136 755712 activation *regulates* [tumour necrosis factor (TNF)-alpha] and interleukin-6 (IL-6) production in cultured renal cells . Regulation TNF ADRB2 12608646 1063080 The present study examined the inhibitory *effect* of activation on the mitogen activated protein kinase (MAPK) cascades and the contribution of these pathways to the suppression of [tumor necrosis factor (TNF)-alpha] in lipopolysaccharide (LPS) stimulated rat renal mesangial cells . Regulation TNF AGO2 12951895 1137393 induced IFN-gamma and [TNF-alpha] *responses* of cells from vaccinated calves and adults were greater than responses of autologous unstimulated cells . Regulation TNF AGTR2 17071582 1637683 Additional in vitro experiments revealed that activation did not *affect* nuclear factor-kappaB activation by [tumor necrosis factor-alpha] in cultured tubular epithelial cells , although it inhibited ERK phosphorylation , which reduced monocyte chemoattractant protein-1 mRNA levels . Regulation TNF AGTR2 17884764 1797365 receptors are *involved* in [alpha-TNF] and IL1 beta secretions in cardiac fibroblasts . Regulation TNF AGXT 15120611 1242026 In addition , an adenosine receptor antagonist <8-SPT> had no *effect* on AICAR induced suppression of [TNF-alpha] levels . Regulation TNF AHR 14746808 1182120 Infection caused transient increases in pulmonary [TNFalpha] , IL-1 , and IFNalpha/beta levels , but neither the kinetics nor magnitude of this response was *affected* by activation . Regulation TNF AHSA1 11920316 926071 Differential *effects* of and extracellular signal regulated kinase mitogen activated protein kinase inhibitors on inducible nitric oxide synthase and [tumor necrosis factor] production in murine macrophages stimulated with Streptococcus pneumoniae . Regulation TNF AKT1 10655266 663549 The *role* of and mitogen activated protein kinase in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Regulation TNF AKT1 10974038 729203 in turn can *regulate* positively the transcriptional activity of interleukin (IL)-2 and [tumor necrosis factor (TNF)-alpha] promoters . Regulation TNF AKT1 10974038 729215 Importantly , *regulates* the production and secretion of IL-2 and [TNF-alpha] in FcepsilonRI stimulated mast cells . Regulation TNF AKT1 10984605 732235 The present study investigates the *role* of in the activation of NF-kappa B by [tumor necrosis factor-alpha] ( TNF alpha , 10 ng/ml ) and PDGF-BB ( 20 ng/ml ) in human vascular smooth muscle cells (SMC) , skin and foreskin fibroblasts . Regulation TNF AKT1 12145106 969696 To determine the *role* of in [TNF-alpha] release , cells were transiently transfected with a dominant negative form of Akt ( K179M ) . Regulation TNF AKT1 17114809 1677186 Furthermore , cyclin D expression was increased by [TNF-alpha] in a SphK- and *dependent* manner . Regulation TNF AKT1 17367758 1713515 Treatment of B16 cells with siRNA targeted to Akt1/2 resulted in TNFalpha suppression , indicating that *plays* an important role in regulation of [TNFalpha] expression . Regulation TNF AKT1 18207479 1876667 [TNFalpha] signaling *involves* PI-3-kinase <(PI3K)/protein kinase B (PKB)> , and p44/42 MAP kinase (MAPK) which are important in NF-kappaB activation . Regulation TNF AKT1 19666677 2144077 Western blot analysis did not demonstrate the *involvement* of or Erk1/2 in [TNF-PostC] , whereas STAT-3 phosphorylation was increased in both IPostC and TNF-PostC . Regulation TNF AKT1 21949832 2488056 Present study investigates the *role* of and Jak/Stat pathway in the IL-10 modulation of [TNF-a] induced cardiomyocyte apoptosis . Regulation TNF AKT1 24151609 2859742 [TNF] a mediated IL-6 secretion is *regulated* by JAK/STAT pathway but not by MEK phosphorylation and phosphorylation in U266 multiple myeloma cells . Regulation TNF AKT2 10974038 729204 in turn can *regulate* positively the transcriptional activity of interleukin (IL)-2 and [tumor necrosis factor (TNF)-alpha] promoters . Regulation TNF AKT2 10974038 729216 Importantly , *regulates* the production and secretion of IL-2 and [TNF-alpha] in FcepsilonRI stimulated mast cells . Regulation TNF AKT2 10984605 732236 The present study investigates the *role* of in the activation of NF-kappa B by [tumor necrosis factor-alpha] ( TNF alpha , 10 ng/ml ) and PDGF-BB ( 20 ng/ml ) in human vascular smooth muscle cells (SMC) , skin and foreskin fibroblasts . Regulation TNF AKT2 12145106 969697 To determine the *role* of in [TNF-alpha] release , cells were transiently transfected with a dominant negative form of Akt ( K179M ) . Regulation TNF AKT2 17114809 1677187 Furthermore , cyclin D expression was increased by [TNF-alpha] in a SphK- and *dependent* manner . Regulation TNF AKT2 17367758 1713516 Treatment of B16 cells with siRNA targeted to Akt1/2 resulted in TNFalpha suppression , indicating that *plays* an important role in regulation of [TNFalpha] expression . Regulation TNF AKT2 19666677 2144078 Western blot analysis did not demonstrate the *involvement* of or Erk1/2 in [TNF-PostC] , whereas STAT-3 phosphorylation was increased in both IPostC and TNF-PostC . Regulation TNF AKT2 21949832 2488057 Present study investigates the *role* of and Jak/Stat pathway in the IL-10 modulation of [TNF-a] induced cardiomyocyte apoptosis . Regulation TNF AKT2 24151609 2859743 [TNF] a mediated IL-6 secretion is *regulated* by JAK/STAT pathway but not by MEK phosphorylation and phosphorylation in U266 multiple myeloma cells . Regulation TNF AKT3 10974038 729205 in turn can *regulate* positively the transcriptional activity of interleukin (IL)-2 and [tumor necrosis factor (TNF)-alpha] promoters . Regulation TNF AKT3 10974038 729217 Importantly , *regulates* the production and secretion of IL-2 and [TNF-alpha] in FcepsilonRI stimulated mast cells . Regulation TNF AKT3 10984605 732237 The present study investigates the *role* of in the activation of NF-kappa B by [tumor necrosis factor-alpha] ( TNF alpha , 10 ng/ml ) and PDGF-BB ( 20 ng/ml ) in human vascular smooth muscle cells (SMC) , skin and foreskin fibroblasts . Regulation TNF AKT3 12145106 969698 To determine the *role* of in [TNF-alpha] release , cells were transiently transfected with a dominant negative form of Akt ( K179M ) . Regulation TNF AKT3 17114809 1677188 Furthermore , cyclin D expression was increased by [TNF-alpha] in a SphK- and *dependent* manner . Regulation TNF AKT3 17367758 1713517 Treatment of B16 cells with siRNA targeted to Akt1/2 resulted in TNFalpha suppression , indicating that *plays* an important role in regulation of [TNFalpha] expression . Regulation TNF AKT3 19666677 2144079 Western blot analysis did not demonstrate the *involvement* of or Erk1/2 in [TNF-PostC] , whereas STAT-3 phosphorylation was increased in both IPostC and TNF-PostC . Regulation TNF AKT3 21949832 2488058 Present study investigates the *role* of and Jak/Stat pathway in the IL-10 modulation of [TNF-a] induced cardiomyocyte apoptosis . Regulation TNF AKT3 24151609 2859744 [TNF] a mediated IL-6 secretion is *regulated* by JAK/STAT pathway but not by MEK phosphorylation and phosphorylation in U266 multiple myeloma cells . Regulation TNF ALB 16450750 1521994 To investigate the *effect* of AGE modified 132m and AGE-human on [TNF-alpha] and IL-1beta secretion by human peritoneal macrophages derived from patients on continuous ambulatory peritoneal dialysis . Regulation TNF ALB 8118908 241928 Cryoprotective *effect* of gelatin and on recombinant human [tumor necrosis factor] liposome . Regulation TNF ALOX5 1906437 161729 The *involvement* of protein kinase C , calcium , and <5-lipoxygenase> in the production of [tumor necrosis factor] by a cloned interleukin-3 dependent cell line with natural cytotoxic activity . Regulation TNF ALPPL2 17609738 1765455 This rat model of dextran sodium sulfate (DSS) induced colitis was to investigate the *effect* of on [tumor necrosis factor (TNF)-alpha] release by peripheral leukocytes . Regulation TNF AMBP 12667621 1075610 These results indicate that AM and AMBP-1 in combination effectively suppress LPS induced TNF-alpha expression and release especially from primary cultured Kupffer cells , suggesting that the downregulatory *effect* of on proinflammatory cytokine [TNF-alpha] may represent a mechanism responsible for their beneficial effects in preventing inflammatory responses and tissue damage in sepsis . Regulation TNF ANG 11928713 927212 The present study was designed to clarify the *role* of in modulating renal [tumor necrosis factor (TNF)-alpha] and interleukin-6 (IL-6) production and to investigate the effect of one dose of Ang II inhibitor on cytokines production following lipopolysaccharide (LPS) to cause endotoxemia . Regulation TNF ANG 14965324 1208873 Our initial studies on renal cyclooxygenase (COX)-2 expression and activity addressed the critical *role* of in increasing [tumor necrosis factor alpha (TNF)] that eventuated in expression of COX-2 in the medullary thick ascending limb ( mTAL ) of the nephron . Regulation TNF ANGPT2 10362677 620124 To determine whether as well as mechanical stress *affect* the production of [tumor necrosis factor (TNF)] in the heart , neonatal rat cardiac myocytes and fibroblasts were cultured separately and treated for 6 h with ANG II , lipopolysaccharide (LPS) , or cyclic mechanical stretch . Regulation TNF ANGPT2 11994255 938873 however , the *effect* of on [TNF] expression in the adult mammalian heart is not known . Regulation TNF ANGPT2 14644777 1210225 In this study we evaluated the *effects* of on [tumor necrosis factor (TNF)-alpha] and MMP-2 production in endothelial cells . Regulation TNF ANGPT2 19628784 2137866 c-Fms expression in HSCs/promonocytes was mainly regulated by [TNF-alpha] derived from BM CD45 ( - ) CD34 ( - ) stromal cells , and specifically *regulated* the TNF-alpha synthesis and release from BM stromal cells . Regulation TNF ANGPT2 22223068 2569091 Losartan dampened the *effects* of on [TNF-a] production throughout the experimental period , demonstrating an AT(1) receptor contribution . Regulation TNF ANPEP 12184631 978133 Up-regulation of N induced by phorbol ester is *involved* in redox regulation and [tumor necrosis factor] alpha production in HL-60 cells . Regulation TNF ANXA1 19553536 2104075 *regulates* macrophage IL-6 and [TNF] via glucocorticoid induced leucine zipper . Regulation TNF ANXA1 22164217 2517881 The results show that can negatively *regulate* phosphorylation of p38 and release of IL-1ß , IL-6 and [TNF-a] in THP-1 cells following propofol intervention and lipopolysaccharide (LPS) stimulation . Regulation TNF ANXA5 24145837 2889497 Our aim was to study the *effects* of on myocardial [tumor necrosis factor-a] expression , cardiac function , and animal survival in endotoxemia . Regulation TNF APC 10930989 720128 We assessed the *effect* of on LPS induced [tumour necrosis factor alpha (TNF-alpha)] production and on the activation of the central proinflammatory transcription factor nuclear factor-kappaB (NF-kappaB) in a THP-1 cell line . Regulation TNF APC 16497622 1528848 The *effect* of on the expression of [tumor necrosis factor (TNF)-alpha] and monocyte chemoattractant protein (MCP)-1 from LI90 stellate cells was also evaluated . Regulation TNF APC 9053444 417225 A activated by LPS had the same inhibitory *effects* on IFN-gamma and [TNF-alpha] production by B10 .BR TCL . Regulation TNF APC 9124369 419519 We investigated the *effect* of on pulmonary vascular injury and the increase in [tumor necrosis factor (TNF)] levels in lipopolysaccharide (LPS) treated rats to determine whether APC reduces LPS induced endothelial damage by inhibiting cytokine production . Regulation TNF APOB 10394297 627355 They show that with a panel of macrophage-like cell lines of varying maturation ( P388D , THP-1 , U937 , HL-60 ) , the ability to produce TNF alpha spontaneously and to synthesize [TNF alpha] in *response* to atherogenic low-density stimulation correlates with the degree of cell differentiation that can be in turn induced by agents such as phorbol myristic acetate . Regulation TNF APOB 10412778 630887 The *effects* of steroids and on the production of IL-8 , [TNF-alpha] , and MCP-1 by peripheral blood mononuclear cells ( PBMCs ) were also determined in some patients . Regulation TNF APOB 14612200 1162861 Here we have investigated whether the state of monocyte-macrophage differentiation can influence [TNF alpha] synthesis in *response* to scavenged modified . Regulation TNF APOB 16411405 1494781 They highly proliferated and were expanded in long-term culture without alterations of their phenotypic and functional properties ( uptake , wound repair , capillary-like network formation , and [TNFalpha] *response* ) . Regulation TNF APOB 23194377 2723998 These data indicate that *affects* the [TNF-a] and IL-6 response of macrophages to P. gingivalis challenge and that MyD88 and TRIF play important roles in P. gingivalis elicited foam cell formation . Regulation TNF APOB 24321067 2880202 To explore the *effects* of oxidized low-density ( ox-LDL ) on P65 , P50 , [tumor necrosis factor-alpha] ( TNF-a ) and interleukin 6 (IL-6) of human umbilical vein endothelial cells ( HUVECs ) . Regulation TNF APOB 8977464 403390 Human monocytes/macrophages release [TNF-alpha] in *response* to . Regulation TNF APP 14642439 1171813 In the present study , we used brain slices from transgenic APP Swedish ( TgAPPsw ) mice and control littermates of different age groups to determine the *effect* of overexpression on the levels of prostaglandin and [tumor necrosis factor alpha (TNFalpha)] release . Regulation TNF APP 8392465 224926 So far , interleukin (IL) 6 , transforming growth factor beta ( TGF beta ) , [tumor necrosis factor alpha (TNF)] and IL-1 have been found to *control* N-glycosylation patterns of . Regulation TNF ARHGEF2 22301607 2580347 Using human umbilical vein endothelial cells , we analyzed the *role* of ( GEF-H1 ) on lipopolysaccharide (LPS) dependent [IL-6/TNF-a] expression in endothelial cells . Regulation TNF ARMS2 23959158 2873264 More importantly , our data indicate that the change in may *affect* C3 , C5 , IL-6 , IL-8 , and [TNF-a] levels , and this may be one of the mechanisms of AMD development . Regulation TNF ARSH 9176558 433755 We investigated the *effect* of intratracheally instilled coal fly ( FA ) and copper smelter dust ( CU ) on the lung integrity and on the ex vivo release of [tumor necrosis factor alpha (TNF-alpha)] by alveolar phagocytes . Regulation TNF ARSI 16011291 1431562 To study the *effect* of on the activities of human [tumor necrosis factor (TNF)] and natural killer cell ( NKC ) in the patients with lung cancer and the underlying mechanism . Regulation TNF ATF2 20663042 2298147 These results indicated that the downregulation of [TNF-alpha] by S. tenuifolia water extract may have *involved* the inhibition of both IkappaBalpha degradation and activation of c-Jun and involving suppression of JNK/SAPK . Regulation TNF ATF2 8552071 347106 [Tumor necrosis factor] alpha gene regulation in activated T cells *involves* and NFATp . Regulation TNF ATF2 8816436 383617 Cell-type-specific *regulation* of the human [tumor necrosis factor] alpha gene in B cells and T cells by NFATp and . Regulation TNF ATP5O 22351078 2561128 The aim of this study was to investigate the *role* of signaling in myocardial [TNF-a] expression during endotoxemia . Regulation TNF ATP5O 9754866 535250 To investigate the *effect* of inhibitors on the production of [TNF-alpha] in rat basophilic leukemia ( RBL-2H3 ) cells . Regulation TNF ATR 24056170 2843139 Moreover , serum interleukin-4 level decreased significantly after treatment with 25 mg/kg and 125 mg/kg ATR , but did not *affect* the expression of interleukin-2 , interferon-? , and [tumor necrosis factor-a] . Regulation TNF AZU1 9826363 550589 In addition , fucoidan and EDTA abrogate the enhancing *effect* of on LPS induced [TNF-alpha] production . Regulation TNF B2M 16516503 1549242 The expression of on trophoblast cell lines did not *affect* [CD56+/TNF-alpha] ( + ) NK cell levels under these experimental conditions . Regulation TNF BAX 18338637 1840184 [ *Effect* of translocation on [TNFalpha] induced apoptosis of human breast cancer MCF7 cells stably expressed hGFP-Bax ] . Regulation TNF BCHE 17872965 1843336 In the present study , we tested the *effects* of a inhibitor , neostigmine , and a muscarinic cholinergic agonist , pilocarpine , on cardiac hypertrophy and [TNF alpha] levels during pressure overload . Regulation TNF BCL10 10954916 724649 Because Bcl-2 family members are known to affect the redox status of the cell , we examined the *effect* of ( L ) expression on [TNF] signaling . Regulation TNF BCL10 17623099 1787134 The expression profile suggested PI3K/AKT activation and NF-kappaB activation through multiple pathways ( TLR/IL1R , [TNF] receptor induced and TCR-like possibly *involving* ) . Regulation TNF BCL3 12907458 1163972 IL-10-inducible negatively *regulates* LPS induced [TNF-alpha] production in macrophages . Regulation TNF BCL3 22782967 2660016 In summary , our novel data suggest that acute alcohol treatment in vitro and in vivo induces molecular signatures of TLR4/LPS tolerance through the induction of , a negative *regulator* of [TNF-a] transcription via its association with NF-?B p50/p50 dimers . Regulation TNF BCL3 24130828 2853355 Here , we define an Incoherent Feed-forward Loop motif in which TNFa induced NF-?B signalling activates expression of the [TNFA] gene itself and also *controls* synthesis of the negative regulator . Regulation TNF BIRC2 17934460 1819722 Using genetic and molecular approaches , we show that positively *regulates* the formation of the [TNF] receptor complex I in endothelial cells , thereby promoting NF-kappaB activation and maintaining vessel integrity and stabilization . Regulation TNF BIRC2 18827186 2012753 Here we show that , once in the cytoplasm , is *involved* in the degradation of the adaptor protein [tumor necrosis factor] receptor associated factor 2 ( TRAF2 ) by the proteosomal machinery . Regulation TNF BIRC3 9294162 452906 These findings suggest that is critically *involved* in [TNF] signaling and exerts positive feedback control on NF-kappaB via an IkappaB targeting mechanism . Regulation TNF BIRC3 9726225 529715 Because may be *involved* in the regulation of [TNF-alpha] signaling , this raises the possibility that depot-specific differences may exist in the regulation of adipocyte apoptosis . Regulation TNF BLM 9839161 552617 These animals demonstrated an increased expression of [TNF] , but not TGF-beta 1 , mRNA in *response* to and did not exhibit histologic evidence of lung injury following BLM exposure . Regulation TNF BMP1 16785566 1577169 AMphi derived from STAT1-deficient mice did not demonstrate increased production of [TNF-alpha] in *response* to plus IFN-beta . Regulation TNF BMP1 16797218 1579063 Bone morphogenetic protein receptors and signaling are *controlled* by [tumor necrosis factor-alpha] in human bone cells . Regulation TNF BMP10 16797218 1579071 Bone morphogenetic protein receptors and signaling are *controlled* by [tumor necrosis factor-alpha] in human bone cells . Regulation TNF BMP15 16797218 1579064 Bone morphogenetic protein receptors and signaling are *controlled* by [tumor necrosis factor-alpha] in human bone cells . Regulation TNF BMP2 16797218 1579065 Bone morphogenetic protein receptors and signaling are *controlled* by [tumor necrosis factor-alpha] in human bone cells . Regulation TNF BMP3 16797218 1579066 Bone morphogenetic protein receptors and signaling are *controlled* by [tumor necrosis factor-alpha] in human bone cells . Regulation TNF BMP4 16797218 1579067 Bone morphogenetic protein receptors and signaling are *controlled* by [tumor necrosis factor-alpha] in human bone cells . Regulation TNF BMP5 16797218 1579068 Bone morphogenetic protein receptors and signaling are *controlled* by [tumor necrosis factor-alpha] in human bone cells . Regulation TNF BMP6 16797218 1579069 Bone morphogenetic protein receptors and signaling are *controlled* by [tumor necrosis factor-alpha] in human bone cells . Regulation TNF BMP7 16797218 1579070 Bone morphogenetic protein receptors and signaling are *controlled* by [tumor necrosis factor-alpha] in human bone cells . Regulation TNF BPI 11876922 893905 The *effects* of the on the inhibition of the release of [TNFalpha] from hepatic Kupffer 's cells were dose-dependant . Regulation TNF BTD 19317165 2007719 can *regulate* [TNF-alpha] and TGF-beta1 levels to suppress the immune inflammatory reaction so as to treat AS . Regulation TNF BTK 11036165 741142 These findings indicate that rather than a PKC dependent mechanism is *involved* in the modulation of [TNFalpha] response by IFbeta-1a on BMECs . Regulation TNF BTK 12810683 1102844 We examined the *role* of in [TNF alpha] production using luciferase reporter adenoviral constructs and have established that overexpression of Btk results in the stabilization of TNF alpha mRNA via the 3 ' untranslated region . Regulation TNF BTK 16751014 1570756 We show that in *response* to LPS , monocytes from patients with XLA induce early mitogen activated protein kinase activation and intracellular [TNF-alpha] and IL-6 production with the same intensity as cells from age- and sex matched control subjects . Regulation TNF BTK 17725607 1848804 In this study we set out to investigate the potential *role* of in Toll-like receptor 9 (TLR9) activation and the production of pro-inflammatory cytokines such as interleukin (IL)-6 , [tumour necrosis factor (TNF)-alpha] and IL-12p40 . Regulation TNF BTLA 24315996 2880136 also negatively *regulated* IL-17 and [TNF] production in CD27 ( - ) ?d T cells . Regulation TNF BTRC 8809429 383145 Changes in the level of mastocytoma mRNA for [TNF alpha] in *response* to stimulation with or fibroblast conditioned media for up to 12 weeks were studied using Northern analysis and changes in the level of TNF alpha protein expression on immunoblot and immunocytochemistry . Regulation TNF BTRC 9858520 555645 Repetitive administration of SCF also can enhance survival in mice that genetically lack tumor necrosis factor (TNF)-alpha , demonstrating that the ability of SCF treatment to improve survival after CLP does not solely reflect *effects* of on mast cell- dependent ( or -independent ) production of [TNF-alpha] . Regulation TNF C1QA 8225388 234855 Inhibitor of C1q secretion suppresses the macrophage response to lipid A for nitric oxide but not for TNF production : evidence for a *role* of in autocrine binding of [TNF] . Regulation TNF C1QA 8225388 234863 Since TNF binding to DHP treated macrophages was reconstituted by the binding of exogenous C1q to the cells , it appears that may be *involved* in the modulation of autocrine binding of [TNF] for subsequent generation of cytotoxic NO . Regulation TNF C1QA 8603439 352189 The *role* of complement subcomponent in the modulation of [TNF-alpha] binding to L929 cells to mediate cytotoxicity and nitric oxide ( NO ) generation was investigated . Regulation TNF C1QA 8660797 364996 The *role* of endogenously synthesized complement subcomponent on autocrine binding of tumor necrosis factors ( TNF-alpha ) and on [TNF-alpha receptor (TNF-R)] mRNA synthesis by mouse macrophages was investigated . Regulation TNF C1QA 8711421 376623 In the present study , the putative *role* of in increasing [TNF-alpha] binding to L929 cells to mediate cytotoxicity was explored . Regulation TNF C1QB 8225388 234856 Inhibitor of C1q secretion suppresses the macrophage response to lipid A for nitric oxide but not for TNF production : evidence for a *role* of in autocrine binding of [TNF] . Regulation TNF C1QB 8225388 234864 Since TNF binding to DHP treated macrophages was reconstituted by the binding of exogenous C1q to the cells , it appears that may be *involved* in the modulation of autocrine binding of [TNF] for subsequent generation of cytotoxic NO . Regulation TNF C1QB 8603439 352190 The *role* of complement subcomponent in the modulation of [TNF-alpha] binding to L929 cells to mediate cytotoxicity and nitric oxide ( NO ) generation was investigated . Regulation TNF C1QB 8660797 364997 The *role* of endogenously synthesized complement subcomponent on autocrine binding of tumor necrosis factors ( TNF-alpha ) and on [TNF-alpha receptor (TNF-R)] mRNA synthesis by mouse macrophages was investigated . Regulation TNF C1QB 8711421 376624 In the present study , the putative *role* of in increasing [TNF-alpha] binding to L929 cells to mediate cytotoxicity was explored . Regulation TNF C3 8617973 353944 We have investigated the *effects* of and C3a desArg on gene expression and protein synthesis of [TNF-alpha] and IL-1 beta in PBMC . Regulation TNF C3 9379023 465806 In this study , we investigated expression of the C3a receptor (C3aR) by human B cells and the *effects* of and C3a ( desArg ) on IgG , [TNF-alpha] , and IL-6 production in Staphylococcus aureus Cowan strain I ( SAC ) /IL-2 activated B cells . Regulation TNF C3AR1 9379023 465807 In this study , we investigated expression of the by human B cells and the *effects* of C3a and C3a ( desArg ) on IgG , [TNF-alpha] , and IL-6 production in Staphylococcus aureus Cowan strain I ( SAC ) /IL-2 activated B cells . Regulation TNF C5 14527377 1148359 The *effects* of on the release of [tumor necrosis factor alpha (TNF alpha)] from synoviocytes were assayed using enzyme linked immunosorbent assays ( ELISA ) . Regulation TNF C5 2207333 142561 We investigated the *effects* of recombinant ( rC5a ) on gene expression and synthesis of interleukin-1 beta (IL-1 beta) and [tumor necrosis factor (TNF)] in fresh human peripheral blood mononuclear cells ( PBMC ) . Regulation TNF C5 3260938 95977 Through the mediation of [TNF] and IL-1 secreted in *response* to , these diverse disorders can share common features of fever , coagulopathy , acute phase protein production , and disordered metabolism . Regulation TNF CA1 21767946 2579284 Over all , we found could act on macrophages and *regulate* the production of [TNF-a] not only in inflammatory diseases but also in tumour microenvironment , which might be another anti-tumour mechanism of CAI . Regulation TNF CA2 11955956 930879 These observations demonstrate that the intracellular may *play* an important role in IgE induced [TNF-alpha] and IL-6 secretion from mast cells via IKKbeta activation . Regulation TNF CA2 17197194 1663831 Here we investigated whether skeletal myocytes produce IL-6 in a *dependent* manner , and whether [TNF-alpha] , an inducer of IL-6 , is affected by these stimuli . Regulation TNF CA2 20599720 2290819 In addition to Ca2+ mobilization through the IP3-receptor , TRPV2 mediated intracellular mobilization is *involved* in NFkappaB dependent [TNFalpha] and IL-6 expression , while extracellular Ca2+ entry is involved in NFkappaB independent IL-6 production . Regulation TNF CA2 8077671 270741 Unlike constitutive secretion , however , the secretion of [TNF] was highly *regulated* by and protein kinase C. Studies with various stimulants and inhibitors indicated that simultaneous mobilization of Ca2+ and activation of protein kinase C were sufficient signals for secretion although optimal production of TNF may be dependent on additional synergistic signals . Regulation TNF CA2 9754866 535249 To investigate the *effect* of inhibitors on the production of [TNF-alpha] in rat basophilic leukemia ( RBL-2H3 ) cells . Regulation TNF CALM3 10718374 676664 Here , we investigated the effect of adherence on *dependent* protein kinase ( CaMK ) II and IV activation of the extracellular-signal regulated kinase ( ERK) 1/2 cascade and on lipopolysaccharide (LPS) induced [TNFalpha] production by human monocytes . Regulation TNF CALM3 17302905 1698996 Because dendritic cells (DCs) orchestrate immune responses , we examined the in vitro *effects* of , azithromycin ( AZM ) and midecamycin (MDM) on the expression of co-stimulatory molecules and production of cytokines [interleukin (IL)-10 , IL-6 , interferon (IFN)-gamma , IL-12p40 , [tumour necrosis factor (TNF)-alpha] ] of murine bone marrow derived DCs by lipopolysaccharide (LPS) stimulation . Regulation TNF CALM3 22989752 2688903 *Involvement* of and calmodulin kinase II in [tumor necrosis factor] alpha induced survival of bone marrow derived macrophages . Regulation TNF CALM3 3363538 92198 As many of these mediators activate protein kinase C , the *effect* of and protein kinase C inhibitors on IL-1 , [TNF] , phorbol ester and LPS stimulated procoagulant activity was determined . Regulation TNF CALM3 8237376 236056 These results suggest that the LPS induced release of [TNF] is *dependent* and PKC may play an important role in this process . Regulation TNF CALM3 8546576 346330 Calcium and *regulate* lipopolysaccharide induced alveolar macrophage production of [tumor necrosis factor] and procoagulant activity . Regulation TNF CALML3 16464382 1522842 To evaluate the *changes* in [tumor necrosis factor-alpha (TNF-alpha)] mRNA expression in peripheral polymorphonuclear leukocyte ( PMNs ) and tissues after in rats . Regulation TNF CARD8 22711073 2621319 *Role* of NLRP3 and in the regulation of [TNF-a] induced IL-1ß release in vascular smooth muscle cells . Regulation TNF CASP1 11847111 912616 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Regulation TNF CASP1 15050407 1229361 P38 mediated activation regulates mercury induced apoptosis and p38 mediated [TNFalpha] *regulates* necrosis in these cells . Regulation TNF CASP1 22957492 2678685 First , rs4077515 to recruitment domain containing protein 9 ( CARD9 ) to response to peptidoglycan , positive *regulation* of [tumor necrosis factor] production , response to exogenous dsRNA , positive regulation of interleukin-6 production , and positive regulation of innate immune response ( nominal p=0.002 , false discovery rate [ FDR ] =0.027 ) . Regulation TNF CASP10 11847111 912617 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Regulation TNF CASP10 15050407 1229362 P38 mediated activation regulates mercury induced apoptosis and p38 mediated [TNFalpha] *regulates* necrosis in these cells . Regulation TNF CASP10 22957492 2678686 First , rs4077515 to recruitment domain containing protein 9 ( CARD9 ) to response to peptidoglycan , positive *regulation* of [tumor necrosis factor] production , response to exogenous dsRNA , positive regulation of interleukin-6 production , and positive regulation of innate immune response ( nominal p=0.002 , false discovery rate [ FDR ] =0.027 ) . Regulation TNF CASP12 11847111 912627 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Regulation TNF CASP12 15050407 1229372 P38 mediated activation regulates mercury induced apoptosis and p38 mediated [TNFalpha] *regulates* necrosis in these cells . Regulation TNF CASP12 22957492 2678696 First , rs4077515 to recruitment domain containing protein 9 ( CARD9 ) to response to peptidoglycan , positive *regulation* of [tumor necrosis factor] production , response to exogenous dsRNA , positive regulation of interleukin-6 production , and positive regulation of innate immune response ( nominal p=0.002 , false discovery rate [ FDR ] =0.027 ) . Regulation TNF CASP14 11847111 912618 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Regulation TNF CASP14 15050407 1229363 P38 mediated activation regulates mercury induced apoptosis and p38 mediated [TNFalpha] *regulates* necrosis in these cells . Regulation TNF CASP14 22957492 2678687 First , rs4077515 to recruitment domain containing protein 9 ( CARD9 ) to response to peptidoglycan , positive *regulation* of [tumor necrosis factor] production , response to exogenous dsRNA , positive regulation of interleukin-6 production , and positive regulation of innate immune response ( nominal p=0.002 , false discovery rate [ FDR ] =0.027 ) . Regulation TNF CASP16 11847111 912628 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Regulation TNF CASP16 15050407 1229373 P38 mediated activation regulates mercury induced apoptosis and p38 mediated [TNFalpha] *regulates* necrosis in these cells . Regulation TNF CASP16 22957492 2678697 First , rs4077515 to recruitment domain containing protein 9 ( CARD9 ) to response to peptidoglycan , positive *regulation* of [tumor necrosis factor] production , response to exogenous dsRNA , positive regulation of interleukin-6 production , and positive regulation of innate immune response ( nominal p=0.002 , false discovery rate [ FDR ] =0.027 ) . Regulation TNF CASP2 11847111 912619 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Regulation TNF CASP2 15050407 1229364 P38 mediated activation regulates mercury induced apoptosis and p38 mediated [TNFalpha] *regulates* necrosis in these cells . Regulation TNF CASP2 22957492 2678688 First , rs4077515 to recruitment domain containing protein 9 ( CARD9 ) to response to peptidoglycan , positive *regulation* of [tumor necrosis factor] production , response to exogenous dsRNA , positive regulation of interleukin-6 production , and positive regulation of innate immune response ( nominal p=0.002 , false discovery rate [ FDR ] =0.027 ) . Regulation TNF CASP3 11847111 912620 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Regulation TNF CASP3 15050407 1229365 P38 mediated activation regulates mercury induced apoptosis and p38 mediated [TNFalpha] *regulates* necrosis in these cells . Regulation TNF CASP3 18305255 1873631 The activated microglia became neurotoxic , killing naive neurons through an apoptotic mechanism that was mediated by [tumor necrosis factor-alpha (TNF-alpha)] , and *involved* activation of both caspase-8 and . Regulation TNF CASP3 18840762 1994076 These results suggest that [TNF-alpha/IFN-gamma] and ANG II induce muscle protein degradation by a common signaling pathway , which is attenuated by HMB , and that this *involves* the initial activation of and -8 , followed by autophosphorylation and activation of PKR , which then leads to increased ROS formation via activation of p38 MAPK . Regulation TNF CASP3 22957492 2678689 First , rs4077515 to recruitment domain containing protein 9 ( CARD9 ) to response to peptidoglycan , positive *regulation* of [tumor necrosis factor] production , response to exogenous dsRNA , positive regulation of interleukin-6 production , and positive regulation of innate immune response ( nominal p=0.002 , false discovery rate [ FDR ] =0.027 ) . Regulation TNF CASP4 11847111 912621 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Regulation TNF CASP4 15050407 1229366 P38 mediated activation regulates mercury induced apoptosis and p38 mediated [TNFalpha] *regulates* necrosis in these cells . Regulation TNF CASP4 22957492 2678690 First , rs4077515 to recruitment domain containing protein 9 ( CARD9 ) to response to peptidoglycan , positive *regulation* of [tumor necrosis factor] production , response to exogenous dsRNA , positive regulation of interleukin-6 production , and positive regulation of innate immune response ( nominal p=0.002 , false discovery rate [ FDR ] =0.027 ) . Regulation TNF CASP5 11847111 912622 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Regulation TNF CASP5 15050407 1229367 P38 mediated activation regulates mercury induced apoptosis and p38 mediated [TNFalpha] *regulates* necrosis in these cells . Regulation TNF CASP5 22957492 2678691 First , rs4077515 to recruitment domain containing protein 9 ( CARD9 ) to response to peptidoglycan , positive *regulation* of [tumor necrosis factor] production , response to exogenous dsRNA , positive regulation of interleukin-6 production , and positive regulation of innate immune response ( nominal p=0.002 , false discovery rate [ FDR ] =0.027 ) . Regulation TNF CASP6 11847111 912623 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Regulation TNF CASP6 15050407 1229368 P38 mediated activation regulates mercury induced apoptosis and p38 mediated [TNFalpha] *regulates* necrosis in these cells . Regulation TNF CASP6 22957492 2678692 First , rs4077515 to recruitment domain containing protein 9 ( CARD9 ) to response to peptidoglycan , positive *regulation* of [tumor necrosis factor] production , response to exogenous dsRNA , positive regulation of interleukin-6 production , and positive regulation of innate immune response ( nominal p=0.002 , false discovery rate [ FDR ] =0.027 ) . Regulation TNF CASP6 24531553 2918967 Together , these data suggest that released from axonal terminals *regulates* microglial [TNF-a] secretion , synaptic plasticity , and inflammatory pain . Regulation TNF CASP7 11847111 912624 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Regulation TNF CASP7 15050407 1229369 P38 mediated activation regulates mercury induced apoptosis and p38 mediated [TNFalpha] *regulates* necrosis in these cells . Regulation TNF CASP7 22957492 2678693 First , rs4077515 to recruitment domain containing protein 9 ( CARD9 ) to response to peptidoglycan , positive *regulation* of [tumor necrosis factor] production , response to exogenous dsRNA , positive regulation of interleukin-6 production , and positive regulation of innate immune response ( nominal p=0.002 , false discovery rate [ FDR ] =0.027 ) . Regulation TNF CASP8 11014343 736365 Inhibition of [TNFalpha] expression in macrophages by SSZ is due to the induction of apoptosis and *involves* the activation of . Regulation TNF CASP8 11847111 912625 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Regulation TNF CASP8 15050407 1229370 P38 mediated activation regulates mercury induced apoptosis and p38 mediated [TNFalpha] *regulates* necrosis in these cells . Regulation TNF CASP8 18305255 1873632 The activated microglia became neurotoxic , killing naive neurons through an apoptotic mechanism that was mediated by [tumor necrosis factor-alpha (TNF-alpha)] , and *involved* activation of both and caspase-3 . Regulation TNF CASP8 18840762 1994077 These results suggest that [TNF-alpha/IFN-gamma] and ANG II induce muscle protein degradation by a common signaling pathway , which is attenuated by HMB , and that this *involves* the initial activation of , followed by autophosphorylation and activation of PKR , which then leads to increased ROS formation via activation of p38 MAPK . Regulation TNF CASP8 22957492 2678694 First , rs4077515 to recruitment domain containing protein 9 ( CARD9 ) to response to peptidoglycan , positive *regulation* of [tumor necrosis factor] production , response to exogenous dsRNA , positive regulation of interleukin-6 production , and positive regulation of innate immune response ( nominal p=0.002 , false discovery rate [ FDR ] =0.027 ) . Regulation TNF CASP8 8681376 370191 *Involvement* of , a novel MORT1/FADD interacting protease , in Fas/APO-1- and [TNF] receptor induced cell death . Regulation TNF CASP9 11847111 912626 We show that bax-deficient myoblasts do not activate caspases and differentiate in the presence of TNFalpha , highlighting a *role* for bax dependent activation in mediating [TNFalpha] effects . Regulation TNF CASP9 15050407 1229371 P38 mediated activation regulates mercury induced apoptosis and p38 mediated [TNFalpha] *regulates* necrosis in these cells . Regulation TNF CASP9 22957492 2678695 First , rs4077515 to recruitment domain containing protein 9 ( CARD9 ) to response to peptidoglycan , positive *regulation* of [tumor necrosis factor] production , response to exogenous dsRNA , positive regulation of interleukin-6 production , and positive regulation of innate immune response ( nominal p=0.002 , false discovery rate [ FDR ] =0.027 ) . Regulation TNF CAV1 18803934 1965116 The *role* of fatty acids and in [tumor necrosis factor] alpha induced endothelial cell activation . Regulation TNF CBL 10544191 564006 It thus appears that inversely *regulates* the expression of EGF and [TNF-alpha] genes in the CNS of TGX rats . Regulation TNF CCK 11833090 910237 To study the *effect* of sulfated ( CCK-8 ) on systemic hypotension , gene and protein expression of [TNF-alpha] in the spleen of lipopolysaccharide (LPS) induced endotoxic shock ( ES ) rats , and further investigate the signal transduction mechanism of p38 mitogen activated protein kinase (MAPK) . Regulation TNF CCL2 24826069 2937677 The levels of TNF-a mRNA and soluble [TNF-a] produced by the microglia in *response* to advanced glycation end product (AGE) induced retinal neuronal were measured with real-time PCR and enzyme linked immunosorbent assay ( ELISA ) . Regulation TNF CCL2 9916692 587483 Three approaches were used to determine the mechanism by which [TNF] *regulates* . Regulation TNF CCL20 15474097 1318889 Our data suggest that was present in follicular fluid and correlated with oocyte maturation , and was *regulated* by IL-1alpha and [TNF-alpha] . Regulation TNF CCL3 16940249 1615477 However , cases with pulmonary edema had significantly lower cellular gamma-interferon ( p = 0.04 ) , lower cellular IL-1beta ( p = 0.04 ) , lower cellular IL-6 ( p = 0.04 ) , lower cellular [tumor necrosis factor-alpha] *response* ( p = 0.04 ) , and lower cellular ( p = 0.04 ) response compared with other cases . Regulation TNF CCNC 12947019 1151646 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF CD14 10639480 660477 Results indicate that *plays* an important role in [tumor necrosis factor] alpha responses to all of the stimuli tested . Regulation TNF CD14 12101079 962452 No association was found between the CD14 -260 genotypes or the TNF-alpha -308 - -260 genotypes and the [TNF-alpha] *response* . Regulation TNF CD14 24068451 2920991 was *involved* in LAMP stimulated production of [tumor necrosis factor (TNF)-a] by blocking CD14 antibody in THP-1 cells . Regulation TNF CD14 24166974 2868290 Sialylation of Campylobacter jejuni endotoxin promotes dendritic cell mediated B cell responses through *dependent* production of IFN-ß and [TNF-a] . Regulation TNF CD14 24489448 2884805 We analyzed *participation* of in [TNF-a] production stimulated with 1-1000 ng/mL of smooth or rough LPS ( sLPS or rLPS ) and in sLPS binding to RAW264 and J744 cells . Regulation TNF CD14 24489448 2884809 Among the two forms of LPS , rLPS induced [TNF-a] production was less *dependent* and could proceed in the absence of serum as an LBP source . Regulation TNF CD14 7528733 291389 Anti-CD14 monoclonal antibodies MY4 and 3C10 inhibited LPS binding protein and *dependent* activation of [TNF-alpha] production by LPS at LPS concentrations up to approximately 1.0 ng/ml. R-HDL ( 2 mg of protein per ml ) blocked TNF-alpha production by LPS from both smooth- and rough-type gram negative bacteria at concentrations up to 100 ng of LPS per ml but had little effect on heat killed gram positive Staphylococcus aureus and no effect on other LPS independent stimuli tested . Regulation TNF CD14 7536782 300307 Our results also suggest that , in P-PEM , in contrast to J774.1 cells and T-PEM , neither PKC nor is *involved* in the LPS induced activation and suppression of [TNF-alpha] gene expression . Regulation TNF CD14 7539547 307047 The *involvement* of in stimulation of [TNF] production from peripheral mononuclear cells isolated from PNH patients . Regulation TNF CD14 7543211 314243 In this study we examined the *involvement* of human serum , recombinant lipopolysaccharide binding protein ( rLBP ) , recombinant ( r ) , CD14 antibodies and recombinant bactericidal permeability increasing factor ( rBPI ) in the induction of [TNF] by Salmonella minnesota LPS of different polysaccharide chain lengths . Regulation TNF CD14 7681082 214212 We conclude that is *involved* in LPS induced release of [TNF-alpha] , IL-6 , and IL-8 by monocytes and alveolar macrophages and that this receptor appears to be able to recognize LPS directly in the absence of serum . Regulation TNF CD14 8975923 408653 The results indicate that ( i ) induction of TNF-alpha by C. neoformans and GXMs strongly depends on complement , ( ii ) MP1 and MP2 induction of TNF-alpha is facilitated by a heat-stable serum factor other than Ig , and ( iii ) may be *involved* in the induction of [TNF-alpha] by MP2 . Regulation TNF CD14 9574560 502554 *Involvement* of and complement receptors CR3 and CR4 in nuclear factor-kappaB activation and [TNF] production induced by lipopolysaccharide and group B streptococcal cell walls . Regulation TNF CD14 9574560 502562 This study was undertaken to evaluate the *role* of and complement receptors type 3 (CR3) and 4 ( CR4 ) in mediating [TNF] release and NF-kappaB activation induced by LPS and cell wall preparations from group B streptococci type III ( GBS ) . Regulation TNF CD14 9574560 502568 LPS and GBS caused [TNF] secretion from human monocytes in a *dependent* manner , and soluble CD14 , LPS binding protein , or their combination potentiated both LPS- and GBS induced activities . Regulation TNF CD14 9655682 521998 CD14 expression is very low in Kupffer cells , and LPS stimulated [TNF-alpha] release is *independent* of in these cells . Regulation TNF CD14 9767415 538603 [TNF-alpha] production is essentially *dependent* , both in the presence or absence of plasma . Regulation TNF CD200 22642833 2700837 We assessed the *effect* of activation by CD200Fc on Aß-induced production of the pro-inflammatory cytokines , interleukin-1ß (IL-1ß) and [tumor necrosis factor-a (TNFa)] and the expression of microglial activation markers , CD68 and CD40 in cultured glia . Regulation TNF CD28 10764820 698934 We demonstrate herein that , in contrast to alphabeta T cells , [TNF-alpha] production in Vgamma9Vdelta2 T lymphocytes is *independent* of costimulation and highly dependent on TcR induced p38 kinase and extracellular signal regulated kinase 2 pathway activation for optimal cytokine release . Regulation TNF CD28 11762949 887865 In contrast , splenic lymphocytes ( CD3+ , CD4+ , or CD8+ ) derived from wild-type and TIA-1-/- mice produced similar amounts of [TNFalpha] in *response* to Con A , PMA/ionomycin , or . Regulation TNF CD28 16137665 1467173 *regulates* glucocorticoid induced [TNF] receptor family related gene expression on CD4+ T cells via IL-2 dependent mechanisms . Regulation TNF CD28 16585559 1544189 Splenic T cells from aly/aly mice ( that have a defective NIK protein ) have a severe impairment in IL-2 and GM-CSF but not [TNF] secretion in *response* to . Regulation TNF CD28 21931118 2516078 Preclinical tests using human PBMCs had failed to announce the rapid release of [TNF] , IFN-? , and other toxic cytokines in *response* to this . Regulation TNF CD28 7511644 250174 IL-2 activated NK cells produced enhanced levels of IFN-gamma and [TNF] in *response* to stimulation with and PMA . Regulation TNF CD300A 18535206 1945553 *regulate* type I interferon and [TNF-alpha] secretion by human plasmacytoid dendritic cells stimulated with TLR7 and TLR9 ligands . Regulation TNF CD38 17217567 1682011 In the present study , we examined the *effects* of on PPARgamma and [TNF-alpha] expression of porcine PBMC and the phagocytic capacity of PMN . Regulation TNF CD38 20167061 2221980 Furthermore the experiment did not indicate significant *effects* of c9,t11- and , c12-CLA-supplementation on gene expression of peroxisome proliferator activated receptor-alpha ( PPARalpha ) , PPARgamma , sterol regulatory element binding protein-1 and [tumor necrosis factor-alpha] in liver tissue . Regulation TNF CD38 21205430 2419600 The aim of the present study was to assess the *effect* of on PPAR? activation , NF-?B activation and [TNF-a] expression in lipopolysaccharide (LPS)-naive and LPS stimulated porcine peripheral blood mononuclear cells ( PBMC ) . Regulation TNF CD38 21205430 2419601 GW9662 , a PPAR? antagonist , completely negated the modulating *effects* of on [TNF-a] expression and NF-?B activity in both LPS-naive and LPS stimulated porcine PBMC . Regulation TNF CD38 21795062 2484688 The objective of this study was to examine the *effect* of on [tumor necrosis factor (TNF)-a] production by lipopolysaccharide (LPS) stimulated porcine peripheral blood mononuclear cells ( PBMCs ) . Regulation TNF CD38 21795062 2484689 The *effects* of on [TNF-a] expression by both LPS-naïve and LPS stimulated PBMCs were inhibited by IL-10 treatment . Regulation TNF CD38 21795062 2484690 The suppressive *effects* of on [TNF-a] production by LPS stimulated porcine PBMCs were inhibited by an anti-IL-10 polyclonal antibody . Regulation TNF CD4 11739237 886114 6. ( + ) T cells are *responsible* for [TNFalpha] release , because the depletion of this subset prevented the release of TNFalpha ( control : 400 +/- 25 ; immunized : 670 +/- 40 ; Regulation TNF CD4 11856640 914382 Production of [tumor necrosis factor-alpha (TNF-alpha)] and other proinflammatory cytokines in RA is largely ( + ) T-cell *dependent* and mostly a result of interferon-gamma (IFN-gamma) secretion . Regulation TNF CD4 15517626 1328664 A similar pattern was seen in [TNF-alpha] positive T cell *responses* . Regulation TNF CD4 22355730 2561309 PMA/ionomycin stimulated [IFN-?+IL-2+TNF-a+] T cell *responses* were decreased in patients with smear positive tuberculosis compared to those with smear negative tuberculosis . Regulation TNF CD4 9269777 450126 CD4+ T cells expressing dn-ras secreted significantly reduced levels of [TNF-alpha] in *response* to . Regulation TNF CD40 9632061 512586 *Involvement* of in [tumor necrosis factor-alpha (TNF-alpha)] secretion from RA synovial fluid mononuclear cells ( SFMC ) was examined by blocking with anti-CD40 antibody . Regulation TNF CD44 10222064 609562 [TNFalpha] and IL-4 regulation of hyaluronan binding to monocyte CD44 *involves* posttranslational modification of . Regulation TNF CD44 19965872 2199594 [Tumor necrosis factor-alpha] *regulates* transforming growth factor-beta dependent epithelial-mesenchymal transition by promoting interaction . Regulation TNF CD79A 18363466 1887872 [Tumor necrosis factor-alpha] is involved in the respiratory immune *response* to injury . Regulation TNF CD79A 23664637 2827824 Plasma interleukin-1 (IL-1) , [tumor necrosis factor] ( TNF ) a , neopterin and the *responses* to Gram negative bacteria were measured . Regulation TNF CD79A 8118031 246576 *Regulation* of [TNF-alpha] and IL-6 release by may be among the antiinflammatory mechanisms preventing an uncontrolled release of potentially noxious levels of inflammatory cytokines during acute and/or chronic inflammation . Regulation TNF CD79A 8262556 239177 We have studied and compared the *effects* of and IgG immune complexes and concanavalin A ( Con A ) on human monocyte [tumour necrosis factor (TNF)] production . Regulation TNF CD8A 11466378 839980 pfp ( -/- ) mice , was noted despite no significant differences in initial hepatic ( + ) T cell IFN-gamma or [TNF] *responses* or in activation of intrahepatic cytotoxic lymphocytes cells capable of killing AdCMV-lacZ infected fibroblast targets . Regulation TNF CD8B 11466378 839981 pfp ( -/- ) mice , was noted despite no significant differences in initial hepatic ( + ) T cell IFN-gamma or [TNF] *responses* or in activation of intrahepatic cytotoxic lymphocytes cells capable of killing AdCMV-lacZ infected fibroblast targets . Regulation TNF CDC42 17018860 1682943 Suppression of [TNFalpha] induction by RhoA is Rho kinase alpha ( ROCKalpha ) independent , but *dependent* , because TNFalpha induction by C3 transferase is attenuated by inhibition of Cdc42 , and constitutively active Cdc42 suffices to activate NF-kappaB and induce TNFalpha . Regulation TNF CDC73 12381675 997379 The lipid mediator *plays* an important role in the phagocytosis of particles , including bacteria , and consequent production of pro-inflammatory cytokines , such as [TNF-alpha] and IL-8 . Regulation TNF CDC73 15316260 1286200 The aim of this study was to determine [tumor necrosis factor alpha (TNF-alpha)] and interleukin-6 (IL-6) release in *response* to induction in peripheral blood mononuclear cells ( PBMCs ) from chronic hepatitis B virus ( HBV ) carriers . Regulation TNF CDC73 15316260 1286220 Compared with group A , PBMCs from naturally immune subjects and chronic HBV carriers produced significantly higher amounts of [TNF-alpha] and IL-6 in *response* to . Regulation TNF CDC73 1613396 191113 Moreover , 6 day- or 7 day differentiated HL-60 cells showed a further increase in [TNF] production in *response* to , and the response was bimodal , similar to that of the less dense subset of monocytes , with peaks at 10 ( -14 ) and 10 ( -7 ) M PAF . Regulation TNF CDC73 1668107 176692 The *effect* of and of two specific PAF antagonists on [tumor necrosis factor (TNF)] induced superoxide production by human polymorphonuclear neutrophils ( PMN ) was examined . Regulation TNF CDC73 1873355 165250 Further , the *role* of released in response to a challenge with LPS in the regulation of [TNF] and IL-6 production was investigated . Regulation TNF CDC73 1873355 165260 *played* a central role in the [TNF] release in the in vitro experiments . Regulation TNF CDC73 2545780 114299 The *effect* of on [TNF] production by rat alveolar macrophages ( AM ) and the role of endogenous leukotriene B4 (LTB4) in this regulation were examined . Regulation TNF CDC73 7821968 285557 In the present study we investigated the *effects* of endotoxin and on [TNF] gene expression . Regulation TNF CDC73 8009983 243906 The results showed that might *play* an important role in the production of [TNF] . Regulation TNF CDC73 8423096 210789 It was concluded that *plays* an important role in endotoxin induced [TNF] production and mortality . Regulation TNF CDC73 8653713 364650 The effect of platelet activating factor (PAF) on experimental pulmonary metastasis by the B16F10 murine melanoma and the possible *involvement* of in the activities of [tumor necrosis factor alpha (TNF-alpha)] and interleukin 1alpha (IL-1alpha) in tumor metastasis were investigated . Regulation TNF CDK19 12947019 1151651 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF CDK8 12947019 1151649 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF CEBPA 9916895 559060 We determined that binding sites for both NF-kappaB ( -186 bp region ) and ( -198 bp region ) are *involved* in [TNF-alpha] and IL-1beta mediated ICAM-1 upregulation . Regulation TNF CEBPB 10754326 682613 [TNF-alpha] gene expression in macrophages : regulation by NF-kappa B is *independent* of c-Jun or . Regulation TNF CEBPB 16850160 1607154 *regulates* [TNF] induced MnSOD expression and protection against apoptosis . Regulation TNF CEBPB 7929820 274668 We present data to show that the expression of [TNF alpha] is *regulated* by the transcription factor ( NF-IL6 ) . Regulation TNF CERK 22009748 2516465 *regulates* the production of [tumor necrosis factor a (TNFa)] via inhibition of TNFa converting enzyme . Regulation TNF CGA 2551628 119045 Characterization of [tumor necrosis factor-alpha] receptors in human and rat thyroid cells and *regulation* of the receptors by . Regulation TNF CHGA 16725215 1570488 Here we report on the *effect* of recombinant human , vasostatin-I , on [TNFalpha] induced gap formation in two model systems of vascular leakage in arterial endothelial cells of bovine pulmonary ( BPAEC ) and coronary ( BCAEC ) origin . Regulation TNF CHP1 17642135 1669025 causes chronic myocyte infection , *affects* apoptosis and [TNF-alpha] production , and may induce cross reactivity with alpha myosin . Regulation TNF CHP2 17642135 1669026 causes chronic myocyte infection , *affects* apoptosis and [TNF-alpha] production , and may induce cross reactivity with alpha myosin . Regulation TNF CHUK 11124824 768966 We analyzed the differential *role* of and I kappa B kinase 2 (IKK2) in [tumor necrosis factor alpha (TNF-alpha)-] and interleukin-1 beta (IL-1 beta) mediated NF-kappa B activation in primary rat hepatocytes . Regulation TNF CHUK 12847684 1109035 To investigate the potential *role* of and IKK-2 in the regulation of nuclear factor kappaB (NF-kappaB) activation and the expression of [tumor necrosis factor alpha (TNFalpha)] , as well as interleukin-1beta (IL-1beta) , IL-6 , IL-8 , vascular endothelial growth factor ( VEGF ) , and matrix metalloproteinases ( MMPs ) , in rheumatoid arthritis ( RA ) . Regulation TNF CHUK 16806191 1580404 The protein kinase COT/Tpl2 is activated by interleukin-1 (IL-1) , [TNFalpha] and lipopolysaccharide , and its activation by these agonists *involves* the catalysed phosphorylation of the p105 regulatory subunit . Regulation TNF CISH 21798687 2472590 Linoleic acid and , trans-11 CLA isomer had no detectable *effects* on LPS induced [TNF-a] production in cultured bovine blood . Regulation TNF CISH 23857174 2817049 Quantitative real time polymerase chain reaction analyses were performed to evaluate the expression of interleukin (IL)-4 , IL-10 , interferon ( IFN ) -? , [tumor necrosis factor (TNF)-a] and peroxisome proliferator activated receptor ( PPAR ) -? in *response* to and LA . Regulation TNF CISH 24659790 2949101 Hepatitis C virus ( HCV ) -induced 3 *regulates* proinflammatory [TNF-a] responses . Regulation TNF CLN3 23047847 2768940 The *effects* of on [TNF-a] secretion are seen at concentrations present in human blood . Regulation TNF CLU 21296198 2425789 In contrast , showed a clear tendency towards increased IL-1ß and IL-6 plasma levels and did not *affect* [TNF-a] . Regulation TNF CLU 9398251 468958 *Effects* of overexpression on [TNFalpha-] and TGFbeta mediated death of L929 cells . Regulation TNF CNR2 22337285 2576445 Here we determined the *effects* of activation and EA on the expression level of IL-1ß , IL-6 and [TNF-a] in inflamed skin tissues . Regulation TNF CNR2 22428664 2630664 We examined the *effects* of µ-opioid and receptor stimulation on phosphorylation of MAPKs and Akt and on IL-1ß , [TNF-a] , IL-6 and NO production in primary mouse microglial cells . Regulation TNF CNTF 8529123 336681 Since the elevation of serum CS is an important feedback mechanism to limit the synthesis of proinflammatory cytokines , particularly tumor necrosis factor (TNF) , we have investigated the *effect* of on both [TNF] production and lipopolysaccharide (LPS) toxicity . Regulation TNF CNTF 8529123 336682 In order to measure the *effects* of on LPS induced [TNF] production in the brain , mice were injected intracerebroventricularly ( i.c.v. ) with 2.5 micrograms/kg LPS . Regulation TNF CNTF 8529123 336684 In vitro , only marginally *affected* [TNF] production by LPS stimulated mouse splenocytes , but it acted synergistically with dexamethasone ( DEX ) in inhibiting TNF production . Regulation TNF CNTN2 12237295 1012360 Because estrogens might prevent osteoporosis by repressing TNF-alpha gene transcription , we investigated whether estrogens inhibit the transcriptional *effects* of on the [TNF-alpha] promoter . Regulation TNF CNTN2 9178902 434275 Both APO ( S ) and APO ( R ) clones exhibited *dependent* upregulation of CD95 ligand and [TNF-alpha] . Regulation TNF CNTN2 9261427 449048 Synthesis of [TNF-alpha] in *response* to soluble occurred in a dose dependent fashion between 0.25 and 75 nM and peaked within 6 h of treatment . Regulation TNF COL1A1 18541003 1971988 In addition , the pro-inflammatory [tumor necrosis factor-alpha (TNF-alpha)] , produced in *response* to , increased MMP-9 production . Regulation TNF COL1A2 18541003 1971989 In addition , the pro-inflammatory [tumor necrosis factor-alpha (TNF-alpha)] , produced in *response* to , increased MMP-9 production . Regulation TNF COQ2 18806307 1840909 *Effects* of on [TNF-alpha] secretion in human and murine monocytic cell lines . Regulation TNF COQ2 19096114 2003927 To test this hypothesis , we studied the *effect* of on the NFkappaB1 dependent pro-inflammatory cytokine [TNF-alpha] . Regulation TNF COQ2 20136458 2208008 Both and placebo supplementation did not *affect* plasma adiponectin and [TNF-alpha] levels . Regulation TNF COQ2 24513070 2886201 [ *Effect* of on the expression of [tumor necrosis factor-a] and interleukin-10 in gingival tissue of experimental periodontitis in rats ] . Regulation TNF COQ2 24513070 2886215 To investigate the *effect* of on the levels of [tumor necrosis factor-a(TNF-a)] and interleukin-10 (IL-10) in gingival tissue of experimental periodontitis in rats . Regulation TNF COQ3 18806307 1840905 *Effects* of on [TNF-alpha] secretion in human and murine monocytic cell lines . Regulation TNF COQ3 19096114 2003923 To test this hypothesis , we studied the *effect* of on the NFkappaB1 dependent pro-inflammatory cytokine [TNF-alpha] . Regulation TNF COQ3 20136458 2208004 Both and placebo supplementation did not *affect* plasma adiponectin and [TNF-alpha] levels . Regulation TNF COQ3 24513070 2886197 [ *Effect* of on the expression of [tumor necrosis factor-a] and interleukin-10 in gingival tissue of experimental periodontitis in rats ] . Regulation TNF COQ3 24513070 2886211 To investigate the *effect* of on the levels of [tumor necrosis factor-a(TNF-a)] and interleukin-10 (IL-10) in gingival tissue of experimental periodontitis in rats . Regulation TNF COQ4 18806307 1840906 *Effects* of on [TNF-alpha] secretion in human and murine monocytic cell lines . Regulation TNF COQ4 19096114 2003924 To test this hypothesis , we studied the *effect* of on the NFkappaB1 dependent pro-inflammatory cytokine [TNF-alpha] . Regulation TNF COQ4 20136458 2208005 Both and placebo supplementation did not *affect* plasma adiponectin and [TNF-alpha] levels . Regulation TNF COQ4 24513070 2886198 [ *Effect* of on the expression of [tumor necrosis factor-a] and interleukin-10 in gingival tissue of experimental periodontitis in rats ] . Regulation TNF COQ4 24513070 2886212 To investigate the *effect* of on the levels of [tumor necrosis factor-a(TNF-a)] and interleukin-10 (IL-10) in gingival tissue of experimental periodontitis in rats . Regulation TNF COQ5 18806307 1840911 *Effects* of on [TNF-alpha] secretion in human and murine monocytic cell lines . Regulation TNF COQ5 19096114 2003929 To test this hypothesis , we studied the *effect* of on the NFkappaB1 dependent pro-inflammatory cytokine [TNF-alpha] . Regulation TNF COQ5 20136458 2208010 Both and placebo supplementation did not *affect* plasma adiponectin and [TNF-alpha] levels . Regulation TNF COQ5 24513070 2886203 [ *Effect* of on the expression of [tumor necrosis factor-a] and interleukin-10 in gingival tissue of experimental periodontitis in rats ] . Regulation TNF COQ5 24513070 2886217 To investigate the *effect* of on the levels of [tumor necrosis factor-a(TNF-a)] and interleukin-10 (IL-10) in gingival tissue of experimental periodontitis in rats . Regulation TNF COQ6 18806307 1840907 *Effects* of on [TNF-alpha] secretion in human and murine monocytic cell lines . Regulation TNF COQ6 19096114 2003925 To test this hypothesis , we studied the *effect* of on the NFkappaB1 dependent pro-inflammatory cytokine [TNF-alpha] . Regulation TNF COQ6 20136458 2208006 Both and placebo supplementation did not *affect* plasma adiponectin and [TNF-alpha] levels . Regulation TNF COQ6 24513070 2886199 [ *Effect* of on the expression of [tumor necrosis factor-a] and interleukin-10 in gingival tissue of experimental periodontitis in rats ] . Regulation TNF COQ6 24513070 2886213 To investigate the *effect* of on the levels of [tumor necrosis factor-a(TNF-a)] and interleukin-10 (IL-10) in gingival tissue of experimental periodontitis in rats . Regulation TNF COQ7 18806307 1840908 *Effects* of on [TNF-alpha] secretion in human and murine monocytic cell lines . Regulation TNF COQ7 19096114 2003926 To test this hypothesis , we studied the *effect* of on the NFkappaB1 dependent pro-inflammatory cytokine [TNF-alpha] . Regulation TNF COQ7 20136458 2208007 Both and placebo supplementation did not *affect* plasma adiponectin and [TNF-alpha] levels . Regulation TNF COQ7 24513070 2886200 [ *Effect* of on the expression of [tumor necrosis factor-a] and interleukin-10 in gingival tissue of experimental periodontitis in rats ] . Regulation TNF COQ7 24513070 2886214 To investigate the *effect* of on the levels of [tumor necrosis factor-a(TNF-a)] and interleukin-10 (IL-10) in gingival tissue of experimental periodontitis in rats . Regulation TNF COQ9 18806307 1840910 *Effects* of on [TNF-alpha] secretion in human and murine monocytic cell lines . Regulation TNF COQ9 19096114 2003928 To test this hypothesis , we studied the *effect* of on the NFkappaB1 dependent pro-inflammatory cytokine [TNF-alpha] . Regulation TNF COQ9 20136458 2208009 Both and placebo supplementation did not *affect* plasma adiponectin and [TNF-alpha] levels . Regulation TNF COQ9 24513070 2886202 [ *Effect* of on the expression of [tumor necrosis factor-a] and interleukin-10 in gingival tissue of experimental periodontitis in rats ] . Regulation TNF COQ9 24513070 2886216 To investigate the *effect* of on the levels of [tumor necrosis factor-a(TNF-a)] and interleukin-10 (IL-10) in gingival tissue of experimental periodontitis in rats . Regulation TNF CPB1 12073205 956722 Blood samples for cytokine levels , [tumor necrosis factor (TNF)-alpha] , and interleukin (IL)-6 *response* to were collected after induction of anesthesia and at the end of CPB before protamine administration . Regulation TNF CPB2 12073205 956723 Blood samples for cytokine levels , [tumor necrosis factor (TNF)-alpha] , and interleukin (IL)-6 *response* to were collected after induction of anesthesia and at the end of CPB before protamine administration . Regulation TNF CREB1 20303596 2230476 *Role* of in modulation of [TNFalpha] and IL-10 expression in LPS stimulated RAW264.7 macrophages . Regulation TNF CREB1 20303596 2230502 Likewise , while over-expression of dominant negative had no *effect* on LPS stimulated [TNFalpha] production , it blocked the suppressive effect of isoproterenol on TNFalpha production in the LPS stimulated macrophages . Regulation TNF CREB3 20303596 2230477 *Role* of in modulation of [TNFalpha] and IL-10 expression in LPS stimulated RAW264.7 macrophages . Regulation TNF CREB3 20303596 2230503 Likewise , while over-expression of dominant negative had no *effect* on LPS stimulated [TNFalpha] production , it blocked the suppressive effect of isoproterenol on TNFalpha production in the LPS stimulated macrophages . Regulation TNF CREB5 20303596 2230475 *Role* of in modulation of [TNFalpha] and IL-10 expression in LPS stimulated RAW264.7 macrophages . Regulation TNF CREB5 20303596 2230501 Likewise , while over-expression of dominant negative had no *effect* on LPS stimulated [TNFalpha] production , it blocked the suppressive effect of isoproterenol on TNFalpha production in the LPS stimulated macrophages . Regulation TNF CRH 12485415 1032928 In the presence of astressin , the *effects* of on [TNF-alpha] release were attenuated . Regulation TNF CRH 12485415 1032949 *effects* on [TNF-alpha] release were also inhibited by specific inhibitors of MEK , the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 mitogen activated protein kinase ( SB203580 ) , but not by H89 . Regulation TNF CRH 15073568 1184293 The aims of the present study were to examine i ) the *effects* of , 10-9 M , 10 ( -8 ) M and 10 ( -7 ) M , on the stimulated production of IFNgamma , IL-10 and [tumor necrosis factor-alpha (TNFalpha)] by human whole blood ; Regulation TNF CRK 11087751 810079 Activation of mitogen activated protein kinase and extracellular signal regulated kinase is *involved* in glass fiber induced [tumor necrosis factor-alpha] production in macrophages . Regulation TNF CRK 11675371 873199 Both extracellular receptor kinase (ERK) and can *regulate* [TNF-alpha] gene transcription induced by CpG DNA . Regulation TNF CRK 15897117 1408551 AOPP-BSA induced [TNF-alpha] secretion in monocytes , and the intracellular signaling *involves* ROS produced by activated NADPH oxidase and subsequent phosphorylation . Regulation TNF CRK 18651635 1967030 Stimulation of macrophage [TNFalpha] production by orthopaedic wear particles requires activation of the ERK1/2/Egr-1 and NF-kappaB pathways but is *independent* of and JNK . Regulation TNF CRK 9418855 480536 These findings provide evidence for a *role* of NaSal induced MAPK activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Regulation TNF CROT 15575964 1347775 Animal and tissue culture studies have shown that is *involved* in interleukin-2 (IL-2) and [tumor necrosis factor-alpha (TNF-alpha)] production by T-cells contributing to T-cell proliferation . Regulation TNF CROT 19689369 2126539 kinase activation *plays* an integral role in the production of pro-inflammatory cytokines such as [TNF] and IL-1beta in this immune cell type . Regulation TNF CROT 20089988 2201571 Furthermore , we found that was *involved* in the induction of [TNF-alpha] mRNA expression in gingiva of mice with experimental periodontitis . Regulation TNF CSDE1 11116146 786606 NF-kappaB activation by the [tumor necrosis factor receptor (TNFR)] *involves* the formation of a termed a signalosome . Regulation TNF CSE 22359478 2520902 This study investigated the *effect* of on cell viability , migration , [tumor necrosis factor (TNF)-a] secretion , and contraction in normal human bronchial smooth muscle cells ( HBSMCs ) . Regulation TNF CSE 22359478 2520904 However , had no *effect* on [TNF-a] secretion and NF-?B activation . Regulation TNF CSF1 14966426 1209027 We examined the *effect* of macrophage colony stimulating factor ( ) on the production of [tumor necrosis factor (TNF)] in a Bacille de Calmette Guérin-lipopolysaccharide challenged mouse model . Regulation TNF CSF1 2199615 138250 The *effect* of human urinary colony stimulating factor ( ) on the production of [tumor necrosis factor (TNF)] in vivo was assessed . Regulation TNF CSF1 9345022 459283 In the presence of [TNF] , activation of Fas almost completely blocked clonogenic growth of lineage depleted (Lin-) bone marrow ( BM ) progenitor cells in *response* to granulocyte-macrophage colony stimulating factor ( GM-CSF ) , , or a combination of multiple cytokines . Regulation TNF CSF2 10764326 683999 Mean [TNF-alpha] release by AM in *response* to was higher in control subjects than in PAP patients due to a low response in three patients . Regulation TNF CSF2 11119498 768402 may also *regulate* IFN-gamma and [TNF-alpha] production and activity in response to infection . Regulation TNF CSF2 11540567 478735 Effect of simulated weightlessness on [TNF-alpha] production and the *response* of bone marrow cells to in rats . Regulation TNF CSF2 1353987 192652 IL-4 , IL-6 , and IFN-gamma had no *effect* on [TNF-alpha] production by T cells activated via either pathway . Regulation TNF CSF2 14966426 1209028 We examined the *effect* of macrophage ( M-CSF ) on the production of [tumor necrosis factor (TNF)] in a Bacille de Calmette Guérin-lipopolysaccharide challenged mouse model . Regulation TNF CSF2 15255647 1184499 Given the stimulatory *effect* of the ligand on the synthesis and release of the pyrogenic cytokine [TNF alpha] , the present study has been undertaken to investigate a possible role of GMCSF receptor in the pathogenesis of both Plasmodium vivax and Plasmodium falciparum malaria . Regulation TNF CSF2 15285308 1278000 The *effect* of recombinant on IL-6 and [TNF-alpha] levels in epithelial ovarian cancer patients who received paclitaxel and cisplatinum : preliminary results . Regulation TNF CSF2 16716600 1570292 Conversely , had no *effect* on the pre-PHx mRNA levels or the PHx induced upregulation of mRNA levels of [TNF-alpha] , IL-1beta , IL-6 , TGF-beta , IL-10 , HGF , and c-Met determined by real-time RT-PCR . Regulation TNF CSF2 17015146 1629420 In the present study , the *effect* of on lipopolysaccharide (LPS) induced [TNF-alpha] release and MAPkinase activation was analysed on the background of a possible immunostimulating activity of this substance . Regulation TNF CSF2 1906383 161698 *Effects* of granulocyte-macrophage ( GM-CSF ) , IL-2 , interferon-gamma (IFN-gamma) , tumour necrosis factor-alpha (TNF-alpha) and IL-6 on the production of immunoreactive IL-1 and [TNF-alpha] by human monocytes . Regulation TNF CSF2 1906383 161705 The *effects* of , IL-2 , IFN-gamma , TNF-alpha and IL-6 on the production of IL-1 ( both secreted and cell associated ) and [TNF-alpha] by peripheral blood monocytes were studied . Regulation TNF CSF2 2129500 150644 The *effect* of recombinant human granulocyte-macrophage colony stimulating factor ( ) on the expression of HLA-DR , and the production of the cytokines interleukin-1 (IL-1) and [tumor necrosis factor alpha (TNF alpha)] by human peripheral blood monocyte enriched populations was investigated . Regulation TNF CSF2 2199615 138251 The *effect* of human urinary ( CSF-1 ) on the production of [tumor necrosis factor (TNF)] in vivo was assessed . Regulation TNF CSF2 2404745 128027 These results suggest that human osteoblasts , which have been shown previously to respond to TNF alpha , can synthesize and release [TNF] in *response* to IL1 and granulocyte-macrophage . Regulation TNF CSF2 7867077 296409 *Regulation* of [TNF-alpha] promoter activity by IL-2 , IFN-gamma , , and IL-4 was examined in the U937 macrophage cell line and the MLA 144 T cell line . Regulation TNF CSF2 8106292 245930 The *effect* of recombinant human macrophage ( rhM-CSF ) on endogenous production of [tumor necrosis factor (TNF)] was investigated in mice . Regulation TNF CSF2 8135145 242145 *Effects* of granulocyte-macrophage on soluble interleukin-2 receptor serum levels and their relation to neopterin and [tumor necrosis factor-alpha] in cancer patients . Regulation TNF CSF2 8219777 231819 *Effect* of on [TNF-alpha] and IL-1-beta production by alveolar macrophages and peripheral blood monocytes from patients with sarcoidosis . Regulation TNF CSF2 8219777 231820 The present studies were designed to examine the regulatory *effect* of on [TNF-alpha] and IL-1 beta production by AM and PM from patients with pulmonary sarcoidosis . Regulation TNF CSF2 8811844 383373 The results show that granulocyte-macrophage , macrophage colony stimulating factor and lipopolysaccharide differently *regulate* [TNF alpha] protein expression and suggest that different isoforms may have different functions . Regulation TNF CSF2 9345022 459284 In the presence of [TNF] , activation of Fas almost completely blocked clonogenic growth of lineage depleted (Lin-) bone marrow ( BM ) progenitor cells in *response* to granulocyte-macrophage colony stimulating factor ( ) , CSF-1 , or a combination of multiple cytokines . Regulation TNF CSF3 1378868 192692 The suppressive *effect* of on LPS induced [TNF] production was also demonstrated in rats . Regulation TNF CSF3 7521152 269292 On the other hand , production of [TNF] in ATRA treated cells was not *affected* by which significantly enhanced granulocytic differentiation . Regulation TNF CSF3 7541223 310370 We investigated the in vitro *effects* of ( G-CSF ) on [tumor necrosis factor-alpha (TNF-alpha)] release from monocytes . Regulation TNF CSF3 9594023 505922 In our study we tested the *effect* of recombinant human ( rhG-CSF ) on [TNFalpha] production in HepG2 cells . Regulation TNF CSK 17690330 1842484 Moreover , inhibition of PKR phosphorylation severely impaired [TNF-alpha] and IL-6 production by AM in *response* to LPS and . Regulation TNF CSK 22525195 2595812 Ciclosporin alone did not alter the expression levels of these transcripts but in the presence of ciclosporin , TNF-a mRNA expression was upregulated in response to all three agonists and both [TNF-a] and IL-8 transcript abundance was increased in *response* to . Regulation TNF CSN2 8872182 389646 While had no significant *effects* on IFN gamma production by ovine blood lymphocytes , and [TNF alpha] production and MCH Class II antigen expression by ovine bronchoalveolar macrophages , it enhanced IL-1 beta production by the macrophages , beta-casein also had no influence on bovine NK cell activity against a virally infected cell line . Regulation TNF CSNK2A1 10938077 737413 [Tumor necrosis factor] alpha induced phosphorylation of RelA/p65 on Ser529 is *controlled* by . Regulation TNF CSNK2A2 10938077 737414 [Tumor necrosis factor] alpha induced phosphorylation of RelA/p65 on Ser529 is *controlled* by . Regulation TNF CSNK2B 10938077 737415 [Tumor necrosis factor] alpha induced phosphorylation of RelA/p65 on Ser529 is *controlled* by . Regulation TNF CSRP1 20676742 2447319 Herein , our studies focused on characterizing the *effect* of on [tumor necrosis factor a (TNF-a)] production and TLR4 related molecular mechanisms in rat vascular smooth muscle cells ( VSMCs ) . Regulation TNF CSRP1 22771801 2639588 Pharmacological inhibition of phosphatidylinositol (PI)-3 kinase by wortmannin partially reversed the *effects* of on adiponectin , [TNF-a] and leptin genes expression . Regulation TNF CSRP1 22771801 2639595 These results collectively suggest that *regulates* adiponectin , [TNF-a] , leptin , IL-6 and PPAR-? genes expression , and that might represent a mechanism by which CRP regulates insulin resistance , obesity and metabolic syndrome . Regulation TNF CSRP1 8482924 218897 Accordingly , we examined the capacity of alveolar macrophages -- relatively accessible human macrophages -- to produce interleukin-1 (IL-1) and [tumor necrosis factor alpha (TNF-alpha)] in *response* to . Regulation TNF CTBS 23666609 2827834 Using the inhibitors of cathepsin enzymatic activity , it was found that and CtL *regulate* [TNF-a] production , the expression and secretion of NPC2 protein , and the mRNA levels of the genes involved in cholesterol trafficking in macrophages . Regulation TNF CTLA4 15629094 1362133 The *effect* of expressed IkappaBalpha and on the expression of [TNF-alpha] of ECV304 cells stimulated with LPS was also investigated . Regulation TNF CTNND1 8639641 362555 *Role* of , a human homologue to the yeast chromosome segregation gene CSE1 , in toxin and [tumor necrosis factor] mediated apoptosis . Regulation TNF CTR9 12381675 997380 The lipid mediator *plays* an important role in the phagocytosis of particles , including bacteria , and consequent production of pro-inflammatory cytokines , such as [TNF-alpha] and IL-8 . Regulation TNF CTR9 15316260 1286201 The aim of this study was to determine [tumor necrosis factor alpha (TNF-alpha)] and interleukin-6 (IL-6) release in *response* to induction in peripheral blood mononuclear cells ( PBMCs ) from chronic hepatitis B virus ( HBV ) carriers . Regulation TNF CTR9 15316260 1286221 Compared with group A , PBMCs from naturally immune subjects and chronic HBV carriers produced significantly higher amounts of [TNF-alpha] and IL-6 in *response* to . Regulation TNF CTR9 1613396 191114 Moreover , 6 day- or 7 day differentiated HL-60 cells showed a further increase in [TNF] production in *response* to , and the response was bimodal , similar to that of the less dense subset of monocytes , with peaks at 10 ( -14 ) and 10 ( -7 ) M PAF . Regulation TNF CTR9 1668107 176693 The *effect* of and of two specific PAF antagonists on [tumor necrosis factor (TNF)] induced superoxide production by human polymorphonuclear neutrophils ( PMN ) was examined . Regulation TNF CTR9 1873355 165251 Further , the *role* of released in response to a challenge with LPS in the regulation of [TNF] and IL-6 production was investigated . Regulation TNF CTR9 1873355 165261 *played* a central role in the [TNF] release in the in vitro experiments . Regulation TNF CTR9 2545780 114300 The *effect* of on [TNF] production by rat alveolar macrophages ( AM ) and the role of endogenous leukotriene B4 (LTB4) in this regulation were examined . Regulation TNF CTR9 7821968 285558 In the present study we investigated the *effects* of endotoxin and on [TNF] gene expression . Regulation TNF CTR9 8009983 243907 The results showed that might *play* an important role in the production of [TNF] . Regulation TNF CTR9 8423096 210790 It was concluded that *plays* an important role in endotoxin induced [TNF] production and mortality . Regulation TNF CTR9 8653713 364651 The effect of platelet activating factor (PAF) on experimental pulmonary metastasis by the B16F10 murine melanoma and the possible *involvement* of in the activities of [tumor necrosis factor alpha (TNF-alpha)] and interleukin 1alpha (IL-1alpha) in tumor metastasis were investigated . Regulation TNF CTSG 16201876 1463898 *Effects* of elastase and on the levels of membrane and soluble [TNFalpha] . Regulation TNF CTXN1 9407552 471325 Since the effects of cerebral ischemia on TNF receptor (TNFR) expression are unknown , we examined the cellular localization and protein expression of [TNF] and its two receptors in the rat cerebral *response* to permanent middle cerebral artery ( MCA ) occlusion . Regulation TNF CTXN2 9407552 471326 Since the effects of cerebral ischemia on TNF receptor (TNFR) expression are unknown , we examined the cellular localization and protein expression of [TNF] and its two receptors in the rat cerebral *response* to permanent middle cerebral artery ( MCA ) occlusion . Regulation TNF CTXN3 9407552 471327 Since the effects of cerebral ischemia on TNF receptor (TNFR) expression are unknown , we examined the cellular localization and protein expression of [TNF] and its two receptors in the rat cerebral *response* to permanent middle cerebral artery ( MCA ) occlusion . Regulation TNF CUL1 11339505 812226 In the present study we investigated the *effect* of and/or IgE on histamine , [TNF-alpha] and chemokines released from bone marrow derived mast cells ( BMMC ) as well as chemokine receptor expression . Regulation TNF CUL1 8809429 383146 Changes in the level of mastocytoma mRNA for [TNF alpha] in *response* to stimulation with or fibroblast conditioned media for up to 12 weeks were studied using Northern analysis and changes in the level of TNF alpha protein expression on immunoblot and immunocytochemistry . Regulation TNF CUL1 9858520 555646 Repetitive administration of SCF also can enhance survival in mice that genetically lack tumor necrosis factor (TNF)-alpha , demonstrating that the ability of SCF treatment to improve survival after CLP does not solely reflect *effects* of on mast cell- dependent ( or -independent ) production of [TNF-alpha] . Regulation TNF CUX1 21459047 2438503 Bronchial biopsies from moderately severe asthmatics were then tested in an explant culture system to assess the *effect* of Der p and , a TNF-a blocking pegylated-antibody Fab , on expression of [TNF-a] and adhesion molecules . Regulation TNF CX3CL1 12824004 1104349 Here , we measured CX3CL1 mRNA and protein induction by human aortic smooth muscle cells ( SMCs ) , another major component of vessel walls , in response to inflammatory stimuli , and analyzed the *effect* of membrane bound on monocyte adhesion , tissue factor ( TF ) expression , and [tumor necrosis factor-alpha (TNF-alpha)] released . Regulation TNF CX3CR1 18025192 1827672 In contrast , pretreatment with 3 nM FKN induced higher levels of IL-23 compared with cells pretreated with 0.03 nM FKN and produced [TNF-alpha] in a *dependent* manner . Regulation TNF CXCL10 12578855 1058253 Although IP-10 mRNA expression was abrogated in TNF-alpha ( -/- ) mice , both CHS development and TNF-alpha mRNA expression occurred normally in IFN-gamma ( -/- ) mice , indicating that the induction of during CHS was primarily *controlled* by [TNF-alpha] . Regulation TNF CXCL2 16771850 1572683 However , it remains elusive whether enterocytes release in response to LPS and TNF via a NF-kappaB dependent pathway and whether this *involves* the endogenous production of [TNF] and PAF . Regulation TNF CXCR2 11535888 854817 *regulation* of [tumor necrosis factor-alpha] adherence dependent peroxide production is significantly diminished after severe injury in human neutrophils . Regulation TNF CXCR2 16429233 1534089 Cellular activity of IL8 is mediated by the receptor , and transcription of IL8 is *controlled* by the cytokine tumour necrosis factor ( [TNFalpha] ) . Regulation TNF CYBB 15795323 1390311 The aim of this study was to investigate the *role* of containing NADH oxidase signaling in cardiomyocyte [TNF-alpha] expression and myocardial dysfunction induced by LPS . Regulation TNF CYP2A 19589095 2105277 Furafylline , a inhibitor , and indomethacin , a PGHS inhibitor , exhibited a significant inhibitory *effect* on [TNFalpha] and IL-1beta production induced by the APAP and LPS combination . Regulation TNF DCN 12853035 1109986 In the present study , we investigated the *effects* of on the production of metalloproteinases ( MMP-1 , -2 , -3 , -9 and -13 ) , tissue inhibitors of metalloproteinases ( TIMP-1 , -2 ) and cytokines ( TGF-beta , IL-1beta , IL-4 and [TNF-alpha] ) . Regulation TNF DDB1 10959811 726313 *Effects* of on the expression of xenobiotic metabolizing enzymes and on nuclear factor-kappaB (NF-kappaB) activation and [tumor necrosis factor-alpha (TNF-alpha)] production by lipopolysaccharide (LPS) , an endotoxin involved in inflammatory responses , were examined in rats and in RAW264.7 cells to investigate mechanistic aspects . Regulation TNF DDB2 10959811 726314 *Effects* of on the expression of xenobiotic metabolizing enzymes and on nuclear factor-kappaB (NF-kappaB) activation and [tumor necrosis factor-alpha (TNF-alpha)] production by lipopolysaccharide (LPS) , an endotoxin involved in inflammatory responses , were examined in rats and in RAW264.7 cells to investigate mechanistic aspects . Regulation TNF DDC 10788575 688930 The enhanced *effects* of on the release of NO and [TNF-alpha] from Kupffer cells was inhibited by N-acetyl-L-cysteine ( an inhibitor of transcription factor NF-kappaB activation ) . Regulation TNF DDC 10788575 688933 The stimulatory *effect* of on both NO and [TNF-alpha] release was inhibited by H-7 ( an inhibitor of protein kinase C ) but not H-8 ( an inhibitor of cAMP dependent protein kinase ) . Regulation TNF DDX39B 18381799 1907074 The *role* of in the regulation of [tumor necrosis factor-a] suggests that BAT1 may regulate the inflammatory response observed in patients with RA . Regulation TNF DDX58 18523264 1922807 Thus , *plays* a key role in the expression of [TNF-alpha] in macrophages in response to LPS stimulation , mainly for the late phase LPS induced expression of TNF-alpha . Regulation TNF DDX58 22013225 2503317 We show that the innate sensing receptor is *involved* in interferon regulatory factor 3 (IRF3) , NF-?B nuclear translocation , p38 activation , and the subsequent interferon ( IFN ) ß , IFN-?1 , and [tumor necrosis factor] a induction during H5N1 infection . Regulation TNF DEFA1B 1421280 202107 [ *Effects* of human defensin on the production of [tumor necrosis factor-alpha] by human blood monocytes in vitro ] . Regulation TNF DNAJC5 7524500 272386 The *effects* of on [tumor necrosis factor-alpha (TNF-alpha)] RNA levels and protein production in human B cells and a B cell line were studied . Regulation TNF DNASE1L3 11783322 766528 To investigate the *effect* of on the serum [tumor necrosis factor (TNF)] and circulating endothelial cell ( CEC ) levels in acute cerebral infarction ( ACI ) patients , and the mechanism of LSD in treating ACI . Regulation TNF DPT 20045926 2192892 We investigated the *effects* of on [tumor necrosis factor-alpha (TNF-alpha)] induced ICAM-1 expression in the mouse lung epithelial cell line , LA4 . Regulation TNF DST 12860292 1111226 In this study , we investigated the *effects* of on the production of nitric oxide ( NO ) and tumor necrosis factor-alpha (TNF-alpha) , and on the level of inducible nitric oxide synthase (iNOS) and [TNF-alpha] gene expression in mouse macrophages . Regulation TNF DST 12860292 1111228 alone did not *affect* NO or [TNF-alpha] production . Regulation TNF DUSP1 15485842 1347353 Our results reveal that critically *regulates* the expression of [TNF-alpha] and interleukin-1 beta in RAW264.7 cells and further suggest a central role for this phosphatase in controlling the inflammatory responses of primary macrophages to Gram positive bacterial infection . Regulation TNF DUSP1 15614136 1357484 We hypothesized that expression induced during tolerance *regulates* [TNF-alpha] expression by inhibiting p38 activity . Regulation TNF DUSP1 17507666 1778270 Since kinase activity is tightly regulated by phosphatases , we hypothesized that the dual specificity phosphatase *regulates* p38 activity and [TNF-alpha] production in alveolar macrophages due to insufficient H ( 2 ) O ( 2 ) generation in response to asbestos . Regulation TNF DUSP14 23229544 2724461 The dual-specificity phosphatase negatively *regulates* [tumor necrosis factor-] and interleukin-1 induced nuclear factor-?B activation by dephosphorylating the protein kinase TAK1 . Regulation TNF DUSP14 23229544 2724464 These findings suggest that negatively *regulates* [TNF-] or IL-1 induced NF-?B activation by dephosphorylating TAK1 at Thr-187 . Regulation TNF DYNLRB1 16461741 1540838 When compared with nontolerant human monocytic THP-1 cells , BLP-tolerant cells had a significant reduction in [tumor necrosis factor alpha (TNF-alpha)] production in *response* to a high-dose ( 86+/-12 vs. 6042+/-245 ng/ml , P < 0.01 ) or LPS ( 341+/-36 vs. 7882+/-318 ng/ml , P < 0.01 ) stimulation . Regulation TNF DYNLRB1 22003201 2503216 Priming of human monocytes or PBMCs with superantigens significantly enhanced proinflammatory cytokine [TNF-a] and IL-6 release in *response* to stimulation . Regulation TNF ECM1 18439917 1920988 The of the vasculature is a major target of inflammatory cytokines , and [TNFalpha] *regulates* ECM metabolism by affecting collagen production . Regulation TNF ECM2 18439917 1920989 The of the vasculature is a major target of inflammatory cytokines , and [TNFalpha] *regulates* ECM metabolism by affecting collagen production . Regulation TNF EDA 14687926 1190277 For in vitro experiments , Kupffer cells were cultured in the presence of 0-270 microM GdCl for 24h following which viability , [TNFalpha] protein production in *response* to LPS ( 10 ng/ml ) , phagocytosis , and and ED2 staining were evaluated . Regulation TNF EDA 21193170 2414248 These findings suggest that ( + ) cells are *involved* in the expression of [TNF-a] and IL-1ß and the subsequent regulation of bone resorption on pressure side . Regulation TNF EDN1 10898092 711867 The findings suggest that an increase in the mucosal level elicited by H. pylori lipopolysaccharide , combined with a decline in cNOS may be *responsible* for the induction of [TNF-alpha] and triggering the inflammatory process . Regulation TNF EDN1 9533826 511051 Our data indicates that [TNF-alpha] *regulates* ET-1 levels in HNPE cells possibly by activating PKC either to stimulate protein synthesis and/or to enhance secretion . Regulation TNF EDNRA 10229544 611047 These findings suggest that *regulates* [TNF] production in murine lung by suppressing LPS receptor expression , mRNA expression and protein synthesis and/or secretion of TNF . Regulation TNF EDNRA 9444616 475302 The generation of [TNF alpha] caused by ET-1 *involves* ( in sequence ) the ( i ) activation of , ( ii ) activation of tyrosine kinase resulting in the phosphorylation of intracellular proteins , ( iii ) the activation of , hitherto , unknown transcription factors , finally resulting in ( iv ) transcription and translation of the TNF alpha gene . Regulation TNF EEF1A2 12231575 988748 We investigated the *effects* of compared with the American Heart Association ( AHA ) Step I Diet on lipoproteins , vasomotor function , [tumor necrosis factor (TNF)-alpha] , and serological markers of plaque stability . Regulation TNF EEF1A2 15698590 1372322 However , the *effects* of on the expression of [TNF-alpha] and activation of NF-kappaB in endothelial cells stimulated by CRP are less studied . Regulation TNF EEF1A2 21985375 2493398 Furthermore , did not *affect* the [tumour necrosis factor (TNF)-a] secretion by lipopolysaccharide (LPS) stimulated PBMC or CD14+ cells in CIU patients . Regulation TNF EGF 12068256 955381 did not *affect* liver mRNA expression of [TNF-alpha] , IL-1beta , IL-6 , and IL-10 , which suggested that these cytokines were not involved in EGF protective effect . Regulation TNF EGF 1551065 184038 In a fifth neoplastic cell line ( papillary carcinoma , NPA ) that constitutively expressed surface DR , its expression was inhibited by both alpha-IFN and [TNF-alpha] and was not *affected* by . Regulation TNF EGF 1658009 169003 [Tumor necrosis factor] alpha and *regulation* of collagenase and stromelysin in adult porcine articular chondrocytes . Regulation TNF EGF 22116041 2541354 However , as it is known that Cbl deficiency damages myelin by increasing tumor necrosis factor (TNF)-a and decreasing levels in rat spinal cord ( SC ) , and that [TNF-a] and EGF *regulate* PrP ( C ) expression in vitro , we investigated whether Cbl deficiency modifies SC PrP ( C ) and PrP ( C ) -mRNA levels in Cbl-D rats . Regulation TNF EGF 23800251 2808000 The chemokine network revealed that ovarian cancer cells commonly expressed high levels of proinflammatory chemokines such as CCL20 , CXCL1-3 and CXCL8 in *response* to or [TNF] . Regulation TNF EGF 8518234 222097 Overall , these results suggest that expression of receptor protein , its intrinsic tyrosine kinase activity , or its phosphotyrosine content may alter TNF cytotoxic signal transduction and *control* [TNF] responsiveness within the ME-180 cell line . Regulation TNF EGFR 15814736 1393157 We have recently observed that signaling *affects* [TNF-alpha-driven] chemokine expression in epidermal keratinocytes , and its functional impairment increases the levels of crucial chemoattractants such as CCL2/MCP-1 , CCL5/RANTES , and CXCL10/IFN-gamma-inducible protein-10 . Regulation TNF EGFR 17934341 1813467 Genistein , a protein tyrosine kinase (PTK) inhibitor , and PD153035 , an EGFR inhibitor , also blocked the increase of TNF-alpha expression by TCDD , indicating the *role* of in TCDD induced [TNF-alpha] expression . Regulation TNF EGFR 17934341 1813492 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of and ERK , but not c-Src , JNK , nor p38 MAPK . Regulation TNF EGFR 23324306 2712653 Here , we compared and monitored the *effects* of inhibitors gefitinib , erlotinib and AG1517 ( PD153035 ) on the mRNA expression levels of Fosl1 , [Tnf] and Ccl2 . Regulation TNF EGR1 11586099 866406 In this trial , the radiation activated promoter *regulates* expression of the [tumor necrosis factor] alpha gene , which is administered by use of the attenuated adenovirus vector . Regulation TNF EGR1 12734378 1087363 Our results indicate that A beta induced expression of cytokines ( [TNF-alpha] and IL-1 beta ) and chemokines ( MCP-1 , IL-8 , and MIP-1 beta ) in THP-1 monocytes *involves* activation of ERK-1/ERK-2 and downstream activation of . Regulation TNF EGR1 14560009 1154024 family members *regulate* nonlymphoid expression of Fas ligand , TRAIL , and [tumor necrosis factor] during immune responses . Regulation TNF EGR1 15940638 1415591 Because chronic ethanol exposure sensitizes macrophages to LPS stimulated TNF-alpha expression , we have investigated the *role* of in mediating increased LPS stimulated [TNF-alpha] expression after chronic ethanol feeding . Regulation TNF EGR1 20653771 2293322 *Involvement* of in CSE induced [TNF-alpha] secretion was determined by using Egr-1 specific siRNA . Regulation TNF EGR1 7918637 269883 To examine the *involvement* of in [TNF] gene regulation , a Krox-24 expression vector was used , pSCTKr24 . Regulation TNF EGR2 14560009 1154025 family members *regulate* nonlymphoid expression of Fas ligand , TRAIL , and [tumor necrosis factor] during immune responses . Regulation TNF EGR3 14560009 1154026 family members *regulate* nonlymphoid expression of Fas ligand , TRAIL , and [tumor necrosis factor] during immune responses . Regulation TNF EGR4 14560009 1154027 family members *regulate* nonlymphoid expression of Fas ligand , TRAIL , and [tumor necrosis factor] during immune responses . Regulation TNF EHMT1 12108020 963138 The production of [TNF-alpha] and IL-1 beta was not *affected* by MEP and at the concentrations which significantly inhibited the proliferative activity and T cell derived cytokine production . Regulation TNF EHMT1 12874341 1115080 Activation of NF-kappa B and AP-1 by P. aeruginosa may be *involved* not only in [TNF-alpha] induction but also in many of the inflammatory responses triggered in the course of infection with P. aeruginosa . Regulation TNF EIF2AK2 16924232 1692197 Overall , our results indicate that differentially *regulates* [TNF] signaling ; Regulation TNF EIF2S1 20110459 2226737 The IFN-gamma and [TNF-alpha] effects in upregulation of stress granule formation and downregulation of Hsp70 were *dependent* , and the effect could be negated by blocking eIF-2alpha phosphorylation with use of an RNA dependent protein kinase inhibitor . Regulation TNF ELAVL1 15596091 1346478 Moreover , results from studies have demonstrated that at least one mRNA binding protein , , is also *involved* in stabilization of [TNF-alpha] mRNA stability after chronic exposure to ethanol . Regulation TNF EPC1 24385987 2883714 In this study , a human EPC/THP-1 monocytic cell coculture system was used to examine *effect* on IL-1 a , IL-1 ß , and [TNF-] a expression in THP-1 cells . Regulation TNF EPC2 24385987 2883715 In this study , a human EPC/THP-1 monocytic cell coculture system was used to examine *effect* on IL-1 a , IL-1 ß , and [TNF-] a expression in THP-1 cells . Regulation TNF EPHB1 16177323 1458143 Our data indicate that the increased and NF-kappaB promoter activities associated with M. smegmatis infected macrophages are *responsible* , at least in part , for the increased [TNF-alpha] and NOS2 production observed in these infected cells and that ERK1/2 is required for Ets/Elk activity and full TNF-alpha production . Regulation TNF EPHB2 11076936 786261 We have studied the *role* of and p38 mitogen activated protein (MAP) kinase in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Regulation TNF EPHB2 11675371 873200 Both and p38 can *regulate* [TNF-alpha] gene transcription induced by CpG DNA . Regulation TNF EPHB2 12543078 1028738 Together , the p43 induced [TNF] production was *controlled* by NFkB , p38 MAPK , and that is dependent on the activities of PLC and PKC . Regulation TNF EPHB2 12673950 1076642 and JNK are also *involved* in ATP induced [TNF] transcription , while p38 regulates the transport of TNF mRNA from the nucleus to the cytosol . Regulation TNF EPHB2 14715932 1197419 Together , these findings indicate that both and JNK are *involved* in the regulation of [TNF] mRNA expression , that p38 is involved in the nucleocytoplasmic transport of TNF mRNA , and that a PTK ( protein tyrosine kinase ) , possibly a member of the src family , acts downstream of the P2X7 receptor to activate JNK and p38 . Regulation TNF EPHB2 15454113 1301144 These results suggest that PA and [TNF-alpha] induce the up-regulation of CD83 and that their action is *regulated* by and JNK . Regulation TNF EPHB2 15792794 1386864 *dependent* induction of [TNFalpha] expression by the environmental contaminant benzo ( a ) pyrene in primary human macrophages . Regulation TNF EPHB2 17606294 1842193 To further characterize the control of TTP function , we examined the combinatorial *effect* of p38 , and JNK activation on [TNF-alpha] post-transcriptional expression and TTP function . Regulation TNF EPHB2 17934341 1813493 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and , but not c-Src , JNK , nor p38 MAPK . Regulation TNF EPHB2 18622138 1984380 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 MAPK and activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Regulation TNF EPHB2 19201817 2061386 Activation of GPR54 resulted in the *dependent* expression of [tumor necrosis factor-alpha] and FasL in a lymphoid cell line , the latter being the main trigger of apoptosis . Regulation TNF EPHB2 19299480 2106080 In the present study , we demonstrate that CGRP is involved in morphine tolerance by differentially regulating the *dependent* up-regulation of IL-1beta , [TNF-alpha] , and microsomal prostaglandin E synthase-1 ( mPGES-1 ) in astrocytes and p38 dependent up-regulation of IL-6 in microglia in the rat spinal cord . Regulation TNF EPHB2 20511709 2270504 Both LPS and GA stimulated the production of IL-6 , IL-10 , IL12p70 and [TNFalpha] in a p38- and/or *dependent* manner . Regulation TNF EPO 21228694 2379613 *Effects* of on pain related behavior and expression of phosphorylated-p38 map kinase and [tumor necrosis factor-alpha] induced by application of autologous nucleus pulposus on nerve root in rat . Regulation TNF EPO 9386984 466440 These findings suggest that systemic [TNF alpha] or IL-1 beta are not involved in the *response* to ACD . Regulation TNF EPX 7774640 308860 In this study , we report the *effect* of , a basic protein contained in eosinophils that binds to several cell types including macrophages , on [tumor necrosis factor (TNF)] production and hydrogen peroxide release by human monocyte derived macrophages . Regulation TNF ETS1 16177323 1458144 Our data indicate that the increased and NF-kappaB promoter activities associated with M. smegmatis infected macrophages are *responsible* , at least in part , for the increased [TNF-alpha] and NOS2 production observed in these infected cells and that ERK1/2 is required for Ets/Elk activity and full TNF-alpha production . Regulation TNF ETS1 7896795 299859 *Regulation* of the human [TNF] promoter by the transcription factor . Regulation TNF ETS1 7896795 299865 These data suggest an essential *role* of for the activation of [TNF] gene transcription . Regulation TNF ETS2 16177323 1458145 Our data indicate that the increased and NF-kappaB promoter activities associated with M. smegmatis infected macrophages are *responsible* , at least in part , for the increased [TNF-alpha] and NOS2 production observed in these infected cells and that ERK1/2 is required for Ets/Elk activity and full TNF-alpha production . Regulation TNF ETS2 7896795 299860 *Regulation* of the human [TNF] promoter by the transcription factor . Regulation TNF ETS2 7896795 299866 These data suggest an essential *role* of for the activation of [TNF] gene transcription . Regulation TNF F2R 12506061 1038286 HCE-T expression of cytokines ( IL-6 , IL-8 , and [TNFalpha] ) in *response* to activation of and -2 was measured by quantitative RT-PCR and ELISA . Regulation TNF F2RL1 12506061 1038287 HCE-T expression of cytokines ( IL-6 , IL-8 , and [TNFalpha] ) in *response* to activation of was measured by quantitative RT-PCR and ELISA . Regulation TNF FABP5 18678477 1960821 Using BMMCs from genetically E-FABP-null mutated mice , we demonstrated that in BMMCs *plays* a key role in the production of [TNF-alpha] following lipopolysaccharide (LPS) stimulation . Regulation TNF FAS 16785543 1577118 We additionally determined that IL-1beta and [TNF-alpha] secretion by beta-glucan stimulated DCs was partially *regulated* by . Regulation TNF FASLG 16785543 1577119 We additionally determined that IL-1beta and [TNF-alpha] secretion by beta-glucan stimulated DCs was partially *regulated* by . Regulation TNF FCER2 10352303 617274 while anti-CD40 and CTLA-4-Fc reduced IL-10 and TNF-alpha levels , did not *affect* [TNF-alpha] while attenuating IL-10 generation . Regulation TNF FCGR3B 10415049 631179 SNAP also suppressed , and L-NMA enhanced , expression of [TNF-alpha] , reported to be involved in activation induced NK cell death , in *response* to cross linking . Regulation TNF FGF1 8384689 214778 To examine the possible role of basic fibroblast growth factor ( FGF ) in regulating the effects of TNF alpha , we tested the *effect* of on TNF alpha mediated PGE2 production and [TNF alpha] receptor expression in human fibroblasts . Regulation TNF FGF10 8384689 214779 To examine the possible role of basic fibroblast growth factor ( FGF ) in regulating the effects of TNF alpha , we tested the *effect* of on TNF alpha mediated PGE2 production and [TNF alpha] receptor expression in human fibroblasts . Regulation TNF FGF11 8384689 214780 To examine the possible role of basic fibroblast growth factor ( FGF ) in regulating the effects of TNF alpha , we tested the *effect* of on TNF alpha mediated PGE2 production and [TNF alpha] receptor expression in human fibroblasts . Regulation TNF FGF12 8384689 214781 To examine the possible role of basic fibroblast growth factor ( FGF ) in regulating the effects of TNF alpha , we tested the *effect* of on TNF alpha mediated PGE2 production and [TNF alpha] receptor expression in human fibroblasts . Regulation TNF FGF13 8384689 214782 To examine the possible role of basic fibroblast growth factor ( FGF ) in regulating the effects of TNF alpha , we tested the *effect* of on TNF alpha mediated PGE2 production and [TNF alpha] receptor expression in human fibroblasts . Regulation TNF FGF14 8384689 214783 To examine the possible role of basic fibroblast growth factor ( FGF ) in regulating the effects of TNF alpha , we tested the *effect* of on TNF alpha mediated PGE2 production and [TNF alpha] receptor expression in human fibroblasts . Regulation TNF FGF16 8384689 214784 To examine the possible role of basic fibroblast growth factor ( FGF ) in regulating the effects of TNF alpha , we tested the *effect* of on TNF alpha mediated PGE2 production and [TNF alpha] receptor expression in human fibroblasts . Regulation TNF FGF17 8384689 214785 To examine the possible role of basic fibroblast growth factor ( FGF ) in regulating the effects of TNF alpha , we tested the *effect* of on TNF alpha mediated PGE2 production and [TNF alpha] receptor expression in human fibroblasts . Regulation TNF FGF18 8384689 214786 To examine the possible role of basic fibroblast growth factor ( FGF ) in regulating the effects of TNF alpha , we tested the *effect* of on TNF alpha mediated PGE2 production and [TNF alpha] receptor expression in human fibroblasts . Regulation TNF FGF19 8384689 214787 To examine the possible role of basic fibroblast growth factor ( FGF ) in regulating the effects of TNF alpha , we tested the *effect* of on TNF alpha mediated PGE2 production and [TNF alpha] receptor expression in human fibroblasts . Regulation TNF FGF2 8334230 223742 The *effect* of epidermal growth factor (EGF) , and insulin-like growth factor-1 (IGF-1) on the cytostatic activity of [tumour necrosis factor-alpha (TNF-alpha)] was studied on the breast cancer cell line , T47D . Regulation TNF FGF2 8384689 214788 To examine the possible role of basic fibroblast growth factor ( FGF ) in regulating the effects of TNF alpha , we tested the *effect* of on TNF alpha mediated PGE2 production and [TNF alpha] receptor expression in human fibroblasts . Regulation TNF FGF2 8662985 367895 substantially activated the Raf/MEK/MAPK ( where MEK is mitogen activated protein kinase kinase ) pathway but did not *affect* [TNFalpha] activation of JNK . Regulation TNF FGF20 8384689 214789 To examine the possible role of basic fibroblast growth factor ( FGF ) in regulating the effects of TNF alpha , we tested the *effect* of on TNF alpha mediated PGE2 production and [TNF alpha] receptor expression in human fibroblasts . Regulation TNF FGF21 8384689 214790 To examine the possible role of basic fibroblast growth factor ( FGF ) in regulating the effects of TNF alpha , we tested the *effect* of on TNF alpha mediated PGE2 production and [TNF alpha] receptor expression in human fibroblasts . Regulation TNF FGF22 8384689 214791 To examine the possible role of basic fibroblast growth factor ( FGF ) in regulating the effects of TNF alpha , we tested the *effect* of on TNF alpha mediated PGE2 production and [TNF alpha] receptor expression in human fibroblasts . Regulation TNF FGF23 8384689 214792 To examine the possible role of basic fibroblast growth factor ( FGF ) in regulating the effects of TNF alpha , we tested the *effect* of on TNF alpha mediated PGE2 production and [TNF alpha] receptor expression in human fibroblasts . Regulation TNF FGF3 8384689 214793 To examine the possible role of basic fibroblast growth factor ( FGF ) in regulating the effects of TNF alpha , we tested the *effect* of on TNF alpha mediated PGE2 production and [TNF alpha] receptor expression in human fibroblasts . Regulation TNF FGF4 8384689 214794 To examine the possible role of basic fibroblast growth factor ( FGF ) in regulating the effects of TNF alpha , we tested the *effect* of on TNF alpha mediated PGE2 production and [TNF alpha] receptor expression in human fibroblasts . Regulation TNF FGF5 8384689 214795 To examine the possible role of basic fibroblast growth factor ( FGF ) in regulating the effects of TNF alpha , we tested the *effect* of on TNF alpha mediated PGE2 production and [TNF alpha] receptor expression in human fibroblasts . Regulation TNF FGF6 8384689 214796 To examine the possible role of basic fibroblast growth factor ( FGF ) in regulating the effects of TNF alpha , we tested the *effect* of on TNF alpha mediated PGE2 production and [TNF alpha] receptor expression in human fibroblasts . Regulation TNF FGF7 8384689 214797 To examine the possible role of basic fibroblast growth factor ( FGF ) in regulating the effects of TNF alpha , we tested the *effect* of on TNF alpha mediated PGE2 production and [TNF alpha] receptor expression in human fibroblasts . Regulation TNF FGF8 8384689 214798 To examine the possible role of basic fibroblast growth factor ( FGF ) in regulating the effects of TNF alpha , we tested the *effect* of on TNF alpha mediated PGE2 production and [TNF alpha] receptor expression in human fibroblasts . Regulation TNF FGF9 8384689 214799 To examine the possible role of basic fibroblast growth factor ( FGF ) in regulating the effects of TNF alpha , we tested the *effect* of on TNF alpha mediated PGE2 production and [TNF alpha] receptor expression in human fibroblasts . Regulation TNF FGFR3 20857413 2375595 However , it is still unclear whether *regulates* [TNF-a] production in cardiomyocytes after hypoxia . Regulation TNF FLOT2 18475487 209544 The reducing *effects* of on the release of [TNF] and PAF may explain its anti-inflammatory effect . Regulation TNF FLOT2 18475742 407576 The reducing *effects* of on the release of [TNFalpha] , IL-1 , IL-6 and PAF may explain its anti-inflammatory effect . Regulation TNF FMR1 12921647 1130989 It was investigated that the *effects* of on the production of TNF-alpha , interleukin (IL)-1beta , IL-6 , IL-8 , IL-10 and the soluble [TNF-alpha] receptors ( sTNFR-1 and sTNFR-2 ) from AM in sarcoidosis , as comparison to dexamethasone ( DEX ) . Regulation TNF FMR1 14555589 1153136 In this study , we aimed to investigate the *effects* of on the production of TNF-alpha , interleukin (IL)-1 beta , IL-6 , IL-8 , IL-10 , and the soluble [TNF] receptors ( sTNFRs ) 1 and 2 from AMs in sarcoidosis , and we also compared them with those of dexamethasone ( DEX ) . Regulation TNF FMR1 15061967 1230589 To investigate the *effects* of on the production of [tumor necrosis factor (TNF) alpha] , interleukin (IL)-1beta , IL-6 , IL-8 , IL-10 and the soluble TNF receptors ( sTNFR1 and sTNFR2 ) from AM in EAA , also in comparison with dexamethasone ( DEX ) . Regulation TNF FMR1 17436095 1783617 This study was designed to investigate the *effect* of on [TNF-alpha] production by peripheral blood mononuclear cells ( PBMC ) in patients with NASH . Regulation TNF FMR1 9158047 431647 To test whether *affects* [TNF alpha] serum levels or other variables in this disease , we administered POF ( 20 mg/kg/day intravenously in 150 ml of saline for five days ) randomized versus placebo ( 150 ml of saline without POF ) in addition to standard antimalarial therapy . Regulation TNF FMR1 9927365 588554 In six patients with sarcoidosis we investigated the *effect* of on the enhanced spontaneous [TNF-alpha] production by AM in vitro . Regulation TNF FN1 7648723 318994 The *effect* of on IL-1 alpha , IL-1 beta , [tumour necrosis factor-alpha (TNF-alpha)] , and IL-6 production was investigated with cultured monocytes isolated from human peripheral blood . Regulation TNF FN1 8014614 262538 However , IL-6 and [TNF-alpha] secretion was *affected* by , laminin , collagen type I , and collagen type IV in a concentration dependent manner . Regulation TNF FN1 9178968 434340 The *effect* of on IL-1 alpha , IL-1 beta , [TNF-alpha] , and IL-6 production was investigated with cultured monocytes isolated from human peripheral blood . Regulation TNF FOXE1 10465294 640569 These data suggest that is *involved* in the [TNF-alpha] and IFN-gamma induced suppression of thyroid-specific gene expression . Regulation TNF FOXO4 23860688 2849452 However , ATP had no effect on the expression of and FOXO6 , and EGFR , Akt , and ERK1/2 all *involve* in the release of interleukin (IL)-6 and [tumor necrosis factor-a (TNF-a)] induced by ATP . Regulation TNF FOXO6 23860688 2849451 However , ATP had no effect on the expression of FOXO4 and , and EGFR , Akt , and ERK1/2 all *involve* in the release of interleukin (IL)-6 and [tumor necrosis factor-a (TNF-a)] induced by ATP . Regulation TNF FURIN 17283058 1718388 *Role* for in [tumor necrosis factor] alpha induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway . Regulation TNF FXR1 15548538 1367748 Fragile X-related protein *regulates* proinflammatory cytokine [tumor necrosis factor] expression at the post-transcriptional level . Regulation TNF FXR1 15548538 1367751 Finally , we found that the ablation of FXR1P led to a dramatically enhanced association of the TNF mRNA with polyribosomes demonstrating the important *role* of in the post-transcriptional regulation of [TNF] expression . Regulation TNF GAB1 12065326 954396 Gab1 associated with MEKK3 , and a catalytically inactive form of MEKK3 inhibited TNF-alpha induced c-Jun and NF-kappaB transcriptional activation , suggesting a critical *role* for and MEKK3 in [TNF-alpha] signaling . Regulation TNF GADD45A 22752116 2681936 *regulates* [TNF-a] and IL-6 synthesis in THP-1 cells . Regulation TNF GADD45A 22752116 2681941 We show evidence that may *regulate* [TNF-a] and IL-6 expression in activated THP-1 monocyte cells . Regulation TNF GAL 8179009 256081 The *effects* of the hepatotoxin and lipopolysaccharide (LPS) on hepatic and splenic [TNF-alpha] and MnSOD expression were studied . Regulation TNF GAL 8618866 337604 Polyclonal anti-lectin serum specifically inhibited [TNF-alpha] mRNA induction in *response* to the but not to lipopolysaccharide . Regulation TNF GAL 9199414 438938 Primed BMM produced [TNF-alpha] and NO in *response* to in a dose dependent manner . Regulation TNF GAL 9199414 438941 Antilectin monoclonal antibody IG7 , which recognizes a domain ( amino acids 596 to 818 ) of the TNF-alpha mRNA stimulating region of Gal-lectin , specifically inhibited [TNF-alpha] and iNOS mRNA induction and TNF-alpha and NO production by primed BMM in *response* to ( 100 ng/ml ) . Regulation TNF GAL 9521071 493704 Gene transfer with hIL-4 reduced the serum [tumor necrosis factor (TNF)-alpha] production in *response* to by 80 % from 113.1 pg/ml in mock transfected animals to 22.2 pg/ml ( p < 0.05 ) ; Regulation TNF GALT 21573722 2480879 It was reported that both SSeCKS and <ß-1,4-GalT-I> were *involved* in the LPS induced [tumor necrosis factor-alpha] ( TNF-a ) expression in rat primary astrocytes . Regulation TNF GDNF 20839925 2346509 The *effects* of Alchornea triplinervia ethyl on hydrogen peroxide ( H2O2 ) , nitric oxide ( NO ) and [tumor necrosis factor-a (TNF-a)] production in peritoneal macrophages were investigated using phenol red , Griess reagent and a sandwich immunoassay , respectively . Regulation TNF GH1 20634639 2424538 *Effect* of recombinant on leptin , adiponectin , resistin , interleukin-6 , [tumor necrosis factor-a] and ghrelin levels in growth hormone-deficient children . Regulation TNF GH1 9013974 411856 Inhibitory *effect* of on [TNF-alpha] secretion and nuclear factor-kappaB translocation in lipopolysaccharide stimulated human monocytes . Regulation TNF GOLGA6L2 11306564 826883 Genistein , a specific inhibitor of tyrosine kinase , dramatically diminished both [TNF-alpha] secretion and subsequent MMP-9 release in *response* to or Abeta . Regulation TNF GOT2 18678477 1960820 *regulates* LPS induced [TNF-alpha] production in mast cells . Regulation TNF GP2 11550059 856894 We studied the *effects* of alpha1-acid on [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-10 (IL-10) production and lymphocyte response to phytohemagglutinin in cultured peripheral blood mononuclear leukocytes from 6 healthy donors . Regulation TNF GP2 8755512 377393 Binding of thalidomide to alpha1-acid may be *involved* in its inhibition of [tumor necrosis factor] alpha production . Regulation TNF GP2 8886858 391232 *Effects* of alpha 1-acid on tissue factor expression and [tumor necrosis factor] secretion in human monocytes . Regulation TNF GP2 8886858 391236 We investigated the *effect* of alpha 1-acid ( alpha 1-AGP ) , an acute phase protein , on the induction of the expression of TF and the secretion of [TNF alpha] in human monocytes in vitro . Regulation TNF GP5 11550059 856895 We studied the *effects* of alpha1-acid on [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-10 (IL-10) production and lymphocyte response to phytohemagglutinin in cultured peripheral blood mononuclear leukocytes from 6 healthy donors . Regulation TNF GP5 8755512 377394 Binding of thalidomide to alpha1-acid may be *involved* in its inhibition of [tumor necrosis factor] alpha production . Regulation TNF GP5 8886858 391233 *Effects* of alpha 1-acid on tissue factor expression and [tumor necrosis factor] secretion in human monocytes . Regulation TNF GP5 8886858 391237 We investigated the *effect* of alpha 1-acid ( alpha 1-AGP ) , an acute phase protein , on the induction of the expression of TF and the secretion of [TNF alpha] in human monocytes in vitro . Regulation TNF GP6 11550059 856893 We studied the *effects* of alpha1-acid on [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-10 (IL-10) production and lymphocyte response to phytohemagglutinin in cultured peripheral blood mononuclear leukocytes from 6 healthy donors . Regulation TNF GP6 8755512 377392 Binding of thalidomide to alpha1-acid may be *involved* in its inhibition of [tumor necrosis factor] alpha production . Regulation TNF GP6 8886858 391231 *Effects* of alpha 1-acid on tissue factor expression and [tumor necrosis factor] secretion in human monocytes . Regulation TNF GP6 8886858 391235 We investigated the *effect* of alpha 1-acid ( alpha 1-AGP ) , an acute phase protein , on the induction of the expression of TF and the secretion of [TNF alpha] in human monocytes in vitro . Regulation TNF GP9 11550059 856896 We studied the *effects* of alpha1-acid on [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-10 (IL-10) production and lymphocyte response to phytohemagglutinin in cultured peripheral blood mononuclear leukocytes from 6 healthy donors . Regulation TNF GP9 8755512 377395 Binding of thalidomide to alpha1-acid may be *involved* in its inhibition of [tumor necrosis factor] alpha production . Regulation TNF GP9 8886858 391234 *Effects* of alpha 1-acid on tissue factor expression and [tumor necrosis factor] secretion in human monocytes . Regulation TNF GP9 8886858 391238 We investigated the *effect* of alpha 1-acid ( alpha 1-AGP ) , an acute phase protein , on the induction of the expression of TF and the secretion of [TNF alpha] in human monocytes in vitro . Regulation TNF GPC1 21986851 2567848 The *effects* of on inducibility of [tumor necrosis factor (TNF)-a] , nitric oxide ( NO ) , and nicotinamide adenine dinucleotide phosphate ( NADP ( + ) ) production , as well as bactericidal activity , were investigated in RAW264.7 cells or primary alveolar macrophages . Regulation TNF GPC1 22749982 2734540 The inhibitory *effects* of ( 81-95 ) on LPS induced [TNF-a] production was shown to be closely associated with its ability to induce both LAP ( TGF-ß1 ) and CD152 . Regulation TNF GPC2 21986851 2567849 The *effects* of on inducibility of [tumor necrosis factor (TNF)-a] , nitric oxide ( NO ) , and nicotinamide adenine dinucleotide phosphate ( NADP ( + ) ) production , as well as bactericidal activity , were investigated in RAW264.7 cells or primary alveolar macrophages . Regulation TNF GPC2 22749982 2734541 The inhibitory *effects* of ( 81-95 ) on LPS induced [TNF-a] production was shown to be closely associated with its ability to induce both LAP ( TGF-ß1 ) and CD152 . Regulation TNF GPC3 21986851 2567850 The *effects* of on inducibility of [tumor necrosis factor (TNF)-a] , nitric oxide ( NO ) , and nicotinamide adenine dinucleotide phosphate ( NADP ( + ) ) production , as well as bactericidal activity , were investigated in RAW264.7 cells or primary alveolar macrophages . Regulation TNF GPC3 22749982 2734542 The inhibitory *effects* of ( 81-95 ) on LPS induced [TNF-a] production was shown to be closely associated with its ability to induce both LAP ( TGF-ß1 ) and CD152 . Regulation TNF GPC4 21986851 2567851 The *effects* of on inducibility of [tumor necrosis factor (TNF)-a] , nitric oxide ( NO ) , and nicotinamide adenine dinucleotide phosphate ( NADP ( + ) ) production , as well as bactericidal activity , were investigated in RAW264.7 cells or primary alveolar macrophages . Regulation TNF GPC4 22749982 2734543 The inhibitory *effects* of ( 81-95 ) on LPS induced [TNF-a] production was shown to be closely associated with its ability to induce both LAP ( TGF-ß1 ) and CD152 . Regulation TNF GPC5 21986851 2567852 The *effects* of on inducibility of [tumor necrosis factor (TNF)-a] , nitric oxide ( NO ) , and nicotinamide adenine dinucleotide phosphate ( NADP ( + ) ) production , as well as bactericidal activity , were investigated in RAW264.7 cells or primary alveolar macrophages . Regulation TNF GPC5 22749982 2734544 The inhibitory *effects* of ( 81-95 ) on LPS induced [TNF-a] production was shown to be closely associated with its ability to induce both LAP ( TGF-ß1 ) and CD152 . Regulation TNF GPC6 21986851 2567853 The *effects* of on inducibility of [tumor necrosis factor (TNF)-a] , nitric oxide ( NO ) , and nicotinamide adenine dinucleotide phosphate ( NADP ( + ) ) production , as well as bactericidal activity , were investigated in RAW264.7 cells or primary alveolar macrophages . Regulation TNF GPC6 22749982 2734545 The inhibitory *effects* of ( 81-95 ) on LPS induced [TNF-a] production was shown to be closely associated with its ability to induce both LAP ( TGF-ß1 ) and CD152 . Regulation TNF GPI 2137848 128809 The difference in the M subset 's [TNF] *response* remained even after the FcRI- M phi subset received a 2.5-fold increase in stimulation with the classical M phi induction regimen of IFN gamma plus bacterial cell wall product . Regulation TNF GPI 7591712 334266 These data suggest that ( 1 ) TNF-alpha production , as other proteins , is dependent on the of monocytes , and ( 2 ) [TNF-alpha] production , in contrast to total protein , is *modulated* by Na ( + ) -dependent HCO3- . Regulation TNF GPI 9585810 504528 Adrenergic *regulation* of LPS stimulated [TNF] production by M isolated from rats with streptococcal-cell-wall ( SCW ) -induced arthritis has been examined . Regulation TNF GRAP2 10329111 613036 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , , and MAPK . Regulation TNF GRAP2 11722559 884086 These values closely match the IC ( 5 ) 0 values observed in a cell based TNF alpha release assay implying that *plays* a major role in [TNF alpha] release . Regulation TNF GRAP2 11834148 892983 Regulative *effect* of on release of [TNFalpha] and NO from alveolar macrophages under endotoxin stimulation . Regulation TNF GRAP2 11834148 892997 SB203580 , a specific inhibitor of P38MAPK , was used with gradient concentration to evaluate the regulative *effect* of on the release of [TNFalpha] and NO from AM . Regulation TNF GRAP2 15050407 1229374 mediated caspase activation regulates mercury induced apoptosis and p38 mediated [TNFalpha] *regulates* necrosis in these cells . Regulation TNF GRAP2 15614136 1357485 We hypothesized that MKP-1 expression induced during tolerance *regulates* [TNF-alpha] expression by inhibiting activity . Regulation TNF GRAP2 16081599 1460388 These results indicate that gp120 elicited TNF-alpha production by macrophages involves chemokine receptor mediated PI-3K and MAPK activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that and ERK-1/2 independently *regulate* [TNF-alpha] production . Regulation TNF GRAP2 16259005 1489984 In contrast , inhibition of activity did not *affect* expression of the Th1 cytokines IFN-gamma and [TNF] induced by TCR-stimulation , but decreased IL-12 mediated IFN-gamma expression . Regulation TNF GRAP2 16269458 1509295 An inhibitor of activation ( SB203580 ) had no *effect* on [TNFalpha-] or IL-1beta stimulated PAPP-A expression . Regulation TNF GRAP2 16297883 1502778 Furthermore , the ERK , , JNK , and NF-kappaB mediated pathways are all *involved* in dioscorin mediated [TNF-alpha] production . Regulation TNF GRAP2 18467203 1921443 p38 and JNK were important for TNF-alpha induced stimulation of B1 receptors , whereas NF-kappaB , and JNK were *involved* in [TNF-alpha] induced expression of B2 receptors . Regulation TNF GRAP2 21314908 2393327 Administration of an inhibitor specific to p38 or JNK resulted in varying degrees of attenuation on ApxI induced cytokine expression , suggesting the differential regulatory *roles* of and JNK in IL-1ß , IL-8 and [TNF-a] production . Regulation TNF GRAP2 22143055 2536454 Experiments using specific inhibitors suggested that MEHP induced activation of both and the phosphoinositide-3 (PI3) kinase/Akt pathway were *involved* in the release of [TNF-a] ; Regulation TNF GRAP2 22301607 2580356 and ERK1/2 *regulate* LPS induced [IL-6/TNF-a] expression through an NF-?B dependent manner and an NF-?B independent manner , respectively . Regulation TNF GRP 8982099 403794 Differential *effects* of , neuropeptide Y , somatostatin and vasoactive intestinal peptide on interleukin-1 beta , interleukin-6 and [tumor necrosis factor-alpha] production by whole blood cells from healthy young and old subjects . Regulation TNF GSK3B 18027881 1894625 This study was to investigate the *role* of ( GSK-3beta ) in cardiomyocyte [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Regulation TNF GSK3B 18027881 1894632 Further evidence to support the inhibitory *role* of in [TNF-alpha] expression is that protein kinase B ( Akt ) signaling , an upstream inhibitor of GSK-3beta , promotes TNF-alpha expression in LPS stimulated cardiomyocytes and this action of Akt signaling can be mimicked by GSK-3beta inactivation . Regulation TNF GSK3B 18027881 1894633 Our study demonstrates that *plays* an inhibitory role in cardiomyocyte [TNF-alpha] expression during LPS stimulation , and it may be a potential therapeutic target for sepsis . Regulation TNF GSK3B 19274437 2182424 The present study defines the expression of Toll-like Receptor 2 (TLR2) , and the modulatory *role* of inhibitor on [TLR2/Nuclear Factor-kappa B (NF-kappaB)] signaling following myocardial ischemia-reperfusion ( MI-R ) injury in rats . Regulation TNF GSK3B 19596777 2122959 These results suggest that *regulates* heat inactivated S. aureus induced [TNF-alpha] and NO production in microglia mainly by activating NF-kappaB and probably by inhibiting IL-10 . Regulation TNF GSTM1 11407310 825848 We studied the *effect* of on spontaneous and LPS stimulated [TNF-alpha] production by human peripheral blood mononuclear cells ( PBMCs ) of normal volunteers . Regulation TNF GSTM2 11407310 825849 We studied the *effect* of on spontaneous and LPS stimulated [TNF-alpha] production by human peripheral blood mononuclear cells ( PBMCs ) of normal volunteers . Regulation TNF GSTM3 11407310 825850 We studied the *effect* of on spontaneous and LPS stimulated [TNF-alpha] production by human peripheral blood mononuclear cells ( PBMCs ) of normal volunteers . Regulation TNF GSTM4 11407310 825851 We studied the *effect* of on spontaneous and LPS stimulated [TNF-alpha] production by human peripheral blood mononuclear cells ( PBMCs ) of normal volunteers . Regulation TNF GSTM5 11407310 825852 We studied the *effect* of on spontaneous and LPS stimulated [TNF-alpha] production by human peripheral blood mononuclear cells ( PBMCs ) of normal volunteers . Regulation TNF GTS 22683726 2626476 With the knockdown of a7AChR expression by short interference RNA , *effects* on inhibition of [TNF-a] release were not demonstrable . Regulation TNF HAS1 8195703 259157 By decreasing the extent of polysulfation , the inhibitory *effect* of on [TNF-alpha] production was diminished . Regulation TNF HLA-A 15944290 1416151 Human scFv-G8 ( POS ) T lymphocytes comprising the gamma + CD28 vs the gamma signaling element alone produced substantially more IL-2 , [TNF-alpha] , and IFN-gamma in *response* to ( POS ) melanoma cells . Regulation TNF HLA-DRA 8898955 393183 Taken together , our data indicate that [TNF-alpha] expression is tightly *regulated* by ligands , both at the transcriptional and translational levels . Regulation TNF HLA-DRB1 8898955 393184 Taken together , our data indicate that [TNF-alpha] expression is tightly *regulated* by ligands , both at the transcriptional and translational levels . Regulation TNF HLA-G 16516503 1549241 The expression of on trophoblast cell lines did not *affect* [CD56+/TNF-alpha] ( + ) NK cell levels under these experimental conditions . Regulation TNF HMGB1 20547845 2284903 Here we show that Toll-like receptor 4 (TLR4) , a pivotal receptor for activation of innate immunity and cytokine release , is required for *dependent* activation of macrophage [TNF] release . Regulation TNF HMGCR 19811885 2195910 The inhibitory function of atorvastatin on multiple parameters of main components of inflammatory angiogenesis revealed in this study is clearly associated with the modulatory *effects* of on VEGF , [TNF-alpha] and TGF-beta1 production . Regulation TNF HMHA1 7936825 276043 In whole blood , no significant *effect* of on the release of [TNF] , IL-1 beta , IL-8 , and prostaglandin E2 was found . Regulation TNF HMHA1 9012541 405325 had no *effect* on either [TNF alpha] or elastase release . Regulation TNF HMOX1 10748117 690864 Experiments with HO-1/KO and iNOS/KO mice showed that Allotrap 1258 mediated inhibition of [TNF] was *independent* of and iNOS . Regulation TNF HMOX1 16888021 1596831 , a stress-inducible protein , also *regulates* IL-10 and [TNF-alpha] production . Regulation TNF HMOX1 18334666 1904760 In summary , this study demonstrates that the antiobesity *effect* of induction results in an increase in adiponectin secretion , in vivo and in vitro , a decrease in [TNF-alpha] and IL-6 , and a reduction in weight gain . Regulation TNF HMOX1 23423194 2755342 *Role* of in [TNF/TNF] receptor mediated apoptosis after hepatic ischemia/reperfusion in rats . Regulation TNF HNRNPD 11116146 786607 NF-kappaB activation by the [tumor necrosis factor receptor (TNFR)] *involves* the formation of a termed a signalosome . Regulation TNF HNRNPF 20237317 2265975 We demonstrate that but not macrophages have high levels of IRF5 protein , and that IRF5 is *responsible* for the late-phase expression of [TNF] , which is absent in macrophages . Regulation TNF HNRNPH1 20237317 2265976 We demonstrate that but not macrophages have high levels of IRF5 protein , and that IRF5 is *responsible* for the late-phase expression of [TNF] , which is absent in macrophages . Regulation TNF HNRNPH1 22207023 2549741 This is the first study , which reports the *role* of PDIA3 and in [TNF-a] production in DENV infected cells . Regulation TNF HOXD13 14962496 1182586 We examined the *effect* of spermine ( SPM ) and on [tumor necrosis factor (TNF)alpha] and monocyte chemoattractant protein-1 ( MCP-1 ) secretion from macrophages in various culture conditions , including several protocols of polyamines addition and media supplemented with 0 , 1 or 15 % fetal bovine serum . Regulation TNF HPD 17289434 1698419 Before virulent challenge , BCG vaccination clearly enhanced the ability of BALC , PC and SPC to produce [TNF-alpha] in *response* to stimulation ex vivo . Regulation TNF HPGDS 22327557 2592213 The effects of Cordymin on mortality rate , neurobehavior , grip strength , glutathione content , lipid Peroxidation , glutathione peroxidase activity , glutathione reductase activity , catalase activity , Na ( + ) K ( + ) ATPase activity activity and on the *regulation* of C3 and C4 protein level , polymorphonuclear cells , interleukin-1ß and [tumor necrosis factor-a] in a rat model were studied respectively . Regulation TNF HSF1 11734555 904605 Mutational inactivation of this site blocks the inhibitory *effect* of overexpressed on activity of the minimal [TNFalpha] promoter ( -85/+138 ) in Raw 264.7 murine macrophages , identifying this site as an HSF-1 dependent repressor . Regulation TNF HSF1 18689673 1973628 Heat shock proteins ( hsps ) and the ( HSF-1 ) induced by oxidative stress *regulate* NF-kappaB activation and [TNF-alpha] gene expression in monocytes and macrophages . Regulation TNF HSF2 18689673 1973629 Heat shock proteins ( hsps ) and the ( HSF-1 ) induced by oxidative stress *regulate* NF-kappaB activation and [TNF-alpha] gene expression in monocytes and macrophages . Regulation TNF HSF4 18689673 1973630 Heat shock proteins ( hsps ) and the ( HSF-1 ) induced by oxidative stress *regulate* NF-kappaB activation and [TNF-alpha] gene expression in monocytes and macrophages . Regulation TNF HSF5 18689673 1973627 Heat shock proteins ( hsps ) and the ( HSF-1 ) induced by oxidative stress *regulate* NF-kappaB activation and [TNF-alpha] gene expression in monocytes and macrophages . Regulation TNF HSP90AB1 18689673 1973642 Further , *regulates* [TNF-alpha] production in macrophages contributing to alcohol induced inflammation . Regulation TNF HSPB3 21762402 2472184 Exposed monocytes released interleukin-10 but not [tumor necrosis factor-a] in *response* to , suggesting the possible involvement of secreted female proteins in host immune responses . Regulation TNF HSPD1 11882035 919542 In order to clarify the relative importance of hsp60 in the inflammatory response in periodontal disease , the stimulatory *effect* of human and bacterial on the production of [tumour necrosis factor-alpha (TNF-alpha)] was examined in phorbol myristate acetate ( PMA ) -stimulated THP-1 cells . Regulation TNF HSPG2 17158358 1716900 In this study we investigated the *role* of phosphatidylcholine-specific phospholipase C ( ) in silica stimulated induction of [TNF-alpha] and IL-1beta and how PC-PLC activity is regulated by silica in a rat alveolar macrophage model . Regulation TNF HSPG2 8760826 378178 We have investigated the *role* of a TNF-responsive phosphatidylcholine-specific phospholipase C ( ) for the cytotoxic and proinflammatory activity of [TNF] . Regulation TNF HUNK 11991968 938614 To determine the *role* of in the production of [TNF-alpha] , we focused on the function of its nonstructural protein , NS1 , and established monocytic U937 lines transduced with the NS1 gene under the control of an inducible promoter . Regulation TNF ICAM1 12714560 1093382 We observed that [TNF-alpha] induced 10-fold increase in PMN adhesion to endothelial cells in an *dependent* manner and that this response paralleled the rapid time course of ICAM-1 phosphorylation . Regulation TNF ICMT 15647276 1402293 Here , we have shown that *regulates* [TNF alpha] stimulation of Rac1 activity . Regulation TNF IDO1 11521058 766177 The *effect* of pentoxifylline (PXF) , nimesulide ( NIM ) , and dexamethasone ( DEX ) on the regulation of PGE2 and [TNF-alpha] production was tested . Regulation TNF IFI44 12775717 1119748 Mechanistic studies indicated that , in comparison with PAR1 signaling , prolonged increase of [ Ca2+ ] i and phosphorylation of mitogen activated protein kinases , as well as NFkappaB activation may be *responsible* for PAR4AP induced [TNF-alpha] production in microglia . Regulation TNF IFI44 18207479 1876666 [TNFalpha] signaling *involves* PI-3-kinase (PI3K)/protein kinase B (PKB) , and MAP kinase (MAPK) which are important in NF-kappaB activation . Regulation TNF IFI44 19303658 2064326 In contrast , RAGE stimulated Egr-1 independent pathways *regulate* [TNF-alpha] production and apoptosis in response to I/R. Consistent with these findings , and phospho-JNK MAPK and c-Jun were strikingly suppressed in RAGE ( -/- ) versus WT mice , but not in Egr-1 ( -/- ) mice . Regulation TNF IFNA1 11755467 898915 The in vitro *effects* of on levels of secreted interleukin 6 (IL-6) , [tumor necrosis factor-alpha (TNF alpha)] , and nuclear matrix proteins ( NMP ) were examined in ESKOL , a B-lymphoblastoid cell line resembling hairy cell leukemia (HCL) . Regulation TNF IFNA1 1434798 204648 *Effects* of on the expression of interleukin 1-beta (IL-1) , interleukin 6 (IL-6) , granulocyte-macrophage colony stimulating factor ( GM-CSF ) and [tumor necrosis factor-alpha (TNF)] in acute myeloid leukemia ( AML ) blasts . Regulation TNF IFNA1 1552742 184138 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Regulation TNF IFNA1 1657073 168884 *Regulation* of [tumor necrosis factor] receptor expression by acid-labile from AIDS sera . Regulation TNF IFNA1 9555981 499218 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the , IFN-beta , interleukin-6 (IL-6) , and [tumor necrosis factor-alpha (TNF-alpha)] *response* to NDV but not to Sendai virus . Regulation TNF IFNA1 9719033 528248 Dual regulatory *effects* of , -beta , and -gamma on interleukin-8 gene expression by human gingival fibroblasts in culture upon stimulation with lipopolysaccharide from Prevotella intermedia , interleukin-1alpha , or [tumor necrosis factor-alpha] . Regulation TNF IFNA10 11755467 898916 The in vitro *effects* of on levels of secreted interleukin 6 (IL-6) , [tumor necrosis factor-alpha (TNF alpha)] , and nuclear matrix proteins ( NMP ) were examined in ESKOL , a B-lymphoblastoid cell line resembling hairy cell leukemia (HCL) . Regulation TNF IFNA10 1434798 204649 *Effects* of on the expression of interleukin 1-beta (IL-1) , interleukin 6 (IL-6) , granulocyte-macrophage colony stimulating factor ( GM-CSF ) and [tumor necrosis factor-alpha (TNF)] in acute myeloid leukemia ( AML ) blasts . Regulation TNF IFNA10 1552742 184139 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Regulation TNF IFNA10 1657073 168885 *Regulation* of [tumor necrosis factor] receptor expression by acid-labile from AIDS sera . Regulation TNF IFNA10 9555981 499219 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the , IFN-beta , interleukin-6 (IL-6) , and [tumor necrosis factor-alpha (TNF-alpha)] *response* to NDV but not to Sendai virus . Regulation TNF IFNA10 9719033 528249 Dual regulatory *effects* of , -beta , and -gamma on interleukin-8 gene expression by human gingival fibroblasts in culture upon stimulation with lipopolysaccharide from Prevotella intermedia , interleukin-1alpha , or [tumor necrosis factor-alpha] . Regulation TNF IFNA13 11755467 898917 The in vitro *effects* of on levels of secreted interleukin 6 (IL-6) , [tumor necrosis factor-alpha (TNF alpha)] , and nuclear matrix proteins ( NMP ) were examined in ESKOL , a B-lymphoblastoid cell line resembling hairy cell leukemia (HCL) . Regulation TNF IFNA13 1434798 204650 *Effects* of on the expression of interleukin 1-beta (IL-1) , interleukin 6 (IL-6) , granulocyte-macrophage colony stimulating factor ( GM-CSF ) and [tumor necrosis factor-alpha (TNF)] in acute myeloid leukemia ( AML ) blasts . Regulation TNF IFNA13 1552742 184140 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Regulation TNF IFNA13 1657073 168886 *Regulation* of [tumor necrosis factor] receptor expression by acid-labile from AIDS sera . Regulation TNF IFNA13 9555981 499220 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the , IFN-beta , interleukin-6 (IL-6) , and [tumor necrosis factor-alpha (TNF-alpha)] *response* to NDV but not to Sendai virus . Regulation TNF IFNA13 9719033 528250 Dual regulatory *effects* of , -beta , and -gamma on interleukin-8 gene expression by human gingival fibroblasts in culture upon stimulation with lipopolysaccharide from Prevotella intermedia , interleukin-1alpha , or [tumor necrosis factor-alpha] . Regulation TNF IFNA14 11755467 898918 The in vitro *effects* of on levels of secreted interleukin 6 (IL-6) , [tumor necrosis factor-alpha (TNF alpha)] , and nuclear matrix proteins ( NMP ) were examined in ESKOL , a B-lymphoblastoid cell line resembling hairy cell leukemia (HCL) . Regulation TNF IFNA14 1434798 204651 *Effects* of on the expression of interleukin 1-beta (IL-1) , interleukin 6 (IL-6) , granulocyte-macrophage colony stimulating factor ( GM-CSF ) and [tumor necrosis factor-alpha (TNF)] in acute myeloid leukemia ( AML ) blasts . Regulation TNF IFNA14 1552742 184141 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Regulation TNF IFNA14 1657073 168887 *Regulation* of [tumor necrosis factor] receptor expression by acid-labile from AIDS sera . Regulation TNF IFNA14 9555981 499221 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the , IFN-beta , interleukin-6 (IL-6) , and [tumor necrosis factor-alpha (TNF-alpha)] *response* to NDV but not to Sendai virus . Regulation TNF IFNA14 9719033 528251 Dual regulatory *effects* of , -beta , and -gamma on interleukin-8 gene expression by human gingival fibroblasts in culture upon stimulation with lipopolysaccharide from Prevotella intermedia , interleukin-1alpha , or [tumor necrosis factor-alpha] . Regulation TNF IFNA16 11755467 898919 The in vitro *effects* of on levels of secreted interleukin 6 (IL-6) , [tumor necrosis factor-alpha (TNF alpha)] , and nuclear matrix proteins ( NMP ) were examined in ESKOL , a B-lymphoblastoid cell line resembling hairy cell leukemia (HCL) . Regulation TNF IFNA16 1434798 204652 *Effects* of on the expression of interleukin 1-beta (IL-1) , interleukin 6 (IL-6) , granulocyte-macrophage colony stimulating factor ( GM-CSF ) and [tumor necrosis factor-alpha (TNF)] in acute myeloid leukemia ( AML ) blasts . Regulation TNF IFNA16 1552742 184142 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Regulation TNF IFNA16 1657073 168888 *Regulation* of [tumor necrosis factor] receptor expression by acid-labile from AIDS sera . Regulation TNF IFNA16 9555981 499222 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the , IFN-beta , interleukin-6 (IL-6) , and [tumor necrosis factor-alpha (TNF-alpha)] *response* to NDV but not to Sendai virus . Regulation TNF IFNA16 9719033 528252 Dual regulatory *effects* of , -beta , and -gamma on interleukin-8 gene expression by human gingival fibroblasts in culture upon stimulation with lipopolysaccharide from Prevotella intermedia , interleukin-1alpha , or [tumor necrosis factor-alpha] . Regulation TNF IFNA17 11755467 898920 The in vitro *effects* of on levels of secreted interleukin 6 (IL-6) , [tumor necrosis factor-alpha (TNF alpha)] , and nuclear matrix proteins ( NMP ) were examined in ESKOL , a B-lymphoblastoid cell line resembling hairy cell leukemia (HCL) . Regulation TNF IFNA17 1434798 204653 *Effects* of on the expression of interleukin 1-beta (IL-1) , interleukin 6 (IL-6) , granulocyte-macrophage colony stimulating factor ( GM-CSF ) and [tumor necrosis factor-alpha (TNF)] in acute myeloid leukemia ( AML ) blasts . Regulation TNF IFNA17 1552742 184143 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Regulation TNF IFNA17 1657073 168889 *Regulation* of [tumor necrosis factor] receptor expression by acid-labile from AIDS sera . Regulation TNF IFNA17 9555981 499223 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the , IFN-beta , interleukin-6 (IL-6) , and [tumor necrosis factor-alpha (TNF-alpha)] *response* to NDV but not to Sendai virus . Regulation TNF IFNA17 9719033 528253 Dual regulatory *effects* of , -beta , and -gamma on interleukin-8 gene expression by human gingival fibroblasts in culture upon stimulation with lipopolysaccharide from Prevotella intermedia , interleukin-1alpha , or [tumor necrosis factor-alpha] . Regulation TNF IFNA2 11755467 898921 The in vitro *effects* of on levels of secreted interleukin 6 (IL-6) , [tumor necrosis factor-alpha (TNF alpha)] , and nuclear matrix proteins ( NMP ) were examined in ESKOL , a B-lymphoblastoid cell line resembling hairy cell leukemia (HCL) . Regulation TNF IFNA2 1434798 204654 *Effects* of on the expression of interleukin 1-beta (IL-1) , interleukin 6 (IL-6) , granulocyte-macrophage colony stimulating factor ( GM-CSF ) and [tumor necrosis factor-alpha (TNF)] in acute myeloid leukemia ( AML ) blasts . Regulation TNF IFNA2 1552742 184144 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Regulation TNF IFNA2 1657073 168890 *Regulation* of [tumor necrosis factor] receptor expression by acid-labile from AIDS sera . Regulation TNF IFNA2 9555981 499224 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the , IFN-beta , interleukin-6 (IL-6) , and [tumor necrosis factor-alpha (TNF-alpha)] *response* to NDV but not to Sendai virus . Regulation TNF IFNA2 9719033 528254 Dual regulatory *effects* of , -beta , and -gamma on interleukin-8 gene expression by human gingival fibroblasts in culture upon stimulation with lipopolysaccharide from Prevotella intermedia , interleukin-1alpha , or [tumor necrosis factor-alpha] . Regulation TNF IFNA21 11755467 898922 The in vitro *effects* of on levels of secreted interleukin 6 (IL-6) , [tumor necrosis factor-alpha (TNF alpha)] , and nuclear matrix proteins ( NMP ) were examined in ESKOL , a B-lymphoblastoid cell line resembling hairy cell leukemia (HCL) . Regulation TNF IFNA21 1434798 204655 *Effects* of on the expression of interleukin 1-beta (IL-1) , interleukin 6 (IL-6) , granulocyte-macrophage colony stimulating factor ( GM-CSF ) and [tumor necrosis factor-alpha (TNF)] in acute myeloid leukemia ( AML ) blasts . Regulation TNF IFNA21 1552742 184145 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Regulation TNF IFNA21 1657073 168891 *Regulation* of [tumor necrosis factor] receptor expression by acid-labile from AIDS sera . Regulation TNF IFNA21 9555981 499225 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the , IFN-beta , interleukin-6 (IL-6) , and [tumor necrosis factor-alpha (TNF-alpha)] *response* to NDV but not to Sendai virus . Regulation TNF IFNA21 9719033 528255 Dual regulatory *effects* of , -beta , and -gamma on interleukin-8 gene expression by human gingival fibroblasts in culture upon stimulation with lipopolysaccharide from Prevotella intermedia , interleukin-1alpha , or [tumor necrosis factor-alpha] . Regulation TNF IFNA4 11755467 898923 The in vitro *effects* of on levels of secreted interleukin 6 (IL-6) , [tumor necrosis factor-alpha (TNF alpha)] , and nuclear matrix proteins ( NMP ) were examined in ESKOL , a B-lymphoblastoid cell line resembling hairy cell leukemia (HCL) . Regulation TNF IFNA4 1434798 204656 *Effects* of on the expression of interleukin 1-beta (IL-1) , interleukin 6 (IL-6) , granulocyte-macrophage colony stimulating factor ( GM-CSF ) and [tumor necrosis factor-alpha (TNF)] in acute myeloid leukemia ( AML ) blasts . Regulation TNF IFNA4 1552742 184146 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Regulation TNF IFNA4 1657073 168892 *Regulation* of [tumor necrosis factor] receptor expression by acid-labile from AIDS sera . Regulation TNF IFNA4 9555981 499226 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the , IFN-beta , interleukin-6 (IL-6) , and [tumor necrosis factor-alpha (TNF-alpha)] *response* to NDV but not to Sendai virus . Regulation TNF IFNA4 9719033 528256 Dual regulatory *effects* of , -beta , and -gamma on interleukin-8 gene expression by human gingival fibroblasts in culture upon stimulation with lipopolysaccharide from Prevotella intermedia , interleukin-1alpha , or [tumor necrosis factor-alpha] . Regulation TNF IFNA5 11755467 898924 The in vitro *effects* of on levels of secreted interleukin 6 (IL-6) , [tumor necrosis factor-alpha (TNF alpha)] , and nuclear matrix proteins ( NMP ) were examined in ESKOL , a B-lymphoblastoid cell line resembling hairy cell leukemia (HCL) . Regulation TNF IFNA5 1434798 204657 *Effects* of on the expression of interleukin 1-beta (IL-1) , interleukin 6 (IL-6) , granulocyte-macrophage colony stimulating factor ( GM-CSF ) and [tumor necrosis factor-alpha (TNF)] in acute myeloid leukemia ( AML ) blasts . Regulation TNF IFNA5 1552742 184147 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Regulation TNF IFNA5 1657073 168893 *Regulation* of [tumor necrosis factor] receptor expression by acid-labile from AIDS sera . Regulation TNF IFNA5 9555981 499227 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the , IFN-beta , interleukin-6 (IL-6) , and [tumor necrosis factor-alpha (TNF-alpha)] *response* to NDV but not to Sendai virus . Regulation TNF IFNA5 9719033 528257 Dual regulatory *effects* of , -beta , and -gamma on interleukin-8 gene expression by human gingival fibroblasts in culture upon stimulation with lipopolysaccharide from Prevotella intermedia , interleukin-1alpha , or [tumor necrosis factor-alpha] . Regulation TNF IFNA6 11755467 898925 The in vitro *effects* of on levels of secreted interleukin 6 (IL-6) , [tumor necrosis factor-alpha (TNF alpha)] , and nuclear matrix proteins ( NMP ) were examined in ESKOL , a B-lymphoblastoid cell line resembling hairy cell leukemia (HCL) . Regulation TNF IFNA6 1434798 204658 *Effects* of on the expression of interleukin 1-beta (IL-1) , interleukin 6 (IL-6) , granulocyte-macrophage colony stimulating factor ( GM-CSF ) and [tumor necrosis factor-alpha (TNF)] in acute myeloid leukemia ( AML ) blasts . Regulation TNF IFNA6 1552742 184148 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Regulation TNF IFNA6 1657073 168894 *Regulation* of [tumor necrosis factor] receptor expression by acid-labile from AIDS sera . Regulation TNF IFNA6 9555981 499228 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the , IFN-beta , interleukin-6 (IL-6) , and [tumor necrosis factor-alpha (TNF-alpha)] *response* to NDV but not to Sendai virus . Regulation TNF IFNA6 9719033 528258 Dual regulatory *effects* of , -beta , and -gamma on interleukin-8 gene expression by human gingival fibroblasts in culture upon stimulation with lipopolysaccharide from Prevotella intermedia , interleukin-1alpha , or [tumor necrosis factor-alpha] . Regulation TNF IFNA7 11755467 898926 The in vitro *effects* of on levels of secreted interleukin 6 (IL-6) , [tumor necrosis factor-alpha (TNF alpha)] , and nuclear matrix proteins ( NMP ) were examined in ESKOL , a B-lymphoblastoid cell line resembling hairy cell leukemia (HCL) . Regulation TNF IFNA7 1434798 204659 *Effects* of on the expression of interleukin 1-beta (IL-1) , interleukin 6 (IL-6) , granulocyte-macrophage colony stimulating factor ( GM-CSF ) and [tumor necrosis factor-alpha (TNF)] in acute myeloid leukemia ( AML ) blasts . Regulation TNF IFNA7 1552742 184149 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Regulation TNF IFNA7 1657073 168895 *Regulation* of [tumor necrosis factor] receptor expression by acid-labile from AIDS sera . Regulation TNF IFNA7 9555981 499229 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the , IFN-beta , interleukin-6 (IL-6) , and [tumor necrosis factor-alpha (TNF-alpha)] *response* to NDV but not to Sendai virus . Regulation TNF IFNA7 9719033 528259 Dual regulatory *effects* of , -beta , and -gamma on interleukin-8 gene expression by human gingival fibroblasts in culture upon stimulation with lipopolysaccharide from Prevotella intermedia , interleukin-1alpha , or [tumor necrosis factor-alpha] . Regulation TNF IFNA8 11755467 898927 The in vitro *effects* of on levels of secreted interleukin 6 (IL-6) , [tumor necrosis factor-alpha (TNF alpha)] , and nuclear matrix proteins ( NMP ) were examined in ESKOL , a B-lymphoblastoid cell line resembling hairy cell leukemia (HCL) . Regulation TNF IFNA8 1434798 204660 *Effects* of on the expression of interleukin 1-beta (IL-1) , interleukin 6 (IL-6) , granulocyte-macrophage colony stimulating factor ( GM-CSF ) and [tumor necrosis factor-alpha (TNF)] in acute myeloid leukemia ( AML ) blasts . Regulation TNF IFNA8 1552742 184150 Production of [tumor necrosis factor-alpha] by normal and malignant B lymphocytes in *response* to , interferon-gamma and interleukin-4 . Regulation TNF IFNA8 1657073 168896 *Regulation* of [tumor necrosis factor] receptor expression by acid-labile from AIDS sera . Regulation TNF IFNA8 9555981 499230 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the , IFN-beta , interleukin-6 (IL-6) , and [tumor necrosis factor-alpha (TNF-alpha)] *response* to NDV but not to Sendai virus . Regulation TNF IFNA8 9719033 528260 Dual regulatory *effects* of , -beta , and -gamma on interleukin-8 gene expression by human gingival fibroblasts in culture upon stimulation with lipopolysaccharide from Prevotella intermedia , interleukin-1alpha , or [tumor necrosis factor-alpha] . Regulation TNF IFNB1 11673494 872773 Thus , the IFN-beta gene is an early response gene that is activated in response to L-PAM via a pathway that involves reactive oxygen species , and in turn *plays* an important role in L-PAM induced [TNF-alpha] up-regulation . Regulation TNF IFNB1 12437583 1016185 In primary cultures of human astrocytes , we determined the *effects* of on astrocyte cytokine [[tumor necrosis factor-alpha] ( TNF-alpha ) and interleukin (IL)-6 ] and inducible nitric oxide synthase (iNOS) expression by ribonuclease protection assay and ELISA . Regulation TNF IFNB1 12537690 1034147 An exaggerated production of [TNF-alpha] has been reported in murine viral infections , in which mice become sensitized to low amounts of LPS and both interferon (IFN)-gamma and are *involved* in the macrophage induced release of TNF-alpha . Regulation TNF IFNB1 14698849 1195813 Here we compare modulatory *effects* of on the production of proinflammatory cytokines ( IL-1beta , IL-1alpha , [TNF] , and IL-6 ) and IL-1Ra in human monocytes stimulated by lipopolysaccharides (LPS) and isolated plasma membranes of stimulated T cells ( msHUT ) , which are likely to reflect monocyte activation in acute and chronic inflammation , respectively . Regulation TNF IFNB1 16785566 1577170 AMphi derived from STAT1-deficient mice did not demonstrate increased production of [TNF-alpha] in *response* to PCP plus . Regulation TNF IFNB1 1846503 151687 Antibodies against IFN beta block this synergism , implying a *role* of in the antiviral activity of [TNF] plus IFN gamma . Regulation TNF IFNB1 19231997 2072042 To examine the *effect* of high-dose [ 44 microg administered subcutaneously ( sc ) 3 times weekly ( tiw ) ] on [tumor necrosis factor-alpha (TNF-alpha)] and insulin-like growth factor-1 (IGF-1) levels in patients with relapsing remitting multiple sclerosis ( RRMS ) , and any correlation with clinical and magnetic resonance imaging ( MRI ) data . Regulation TNF IFNB1 2108965 131119 IL-2 alone did not induce the expression of either gene while IFN gamma or had a modest inductive effect on IP-10 but no *effect* on [TNF alpha] expression . Regulation TNF IFNB1 3020123 63239 Despite the inhibitory *effect* of on the IFN-gamma induced stimulation of [TNF] receptor expression , IFN-beta did not inhibit the synergistic enhancement of TNF cytotoxicity by IFN-gamma in HT-29 cells . Regulation TNF IFNB1 3020123 63240 The dissociation between the *effects* of on [TNF] receptor expression and on the cytotoxic activity of TNF in HT-29 cells suggests that TNF receptor modulation is not a major mechanism of synergism between IFN and TNF . Regulation TNF IFNB1 9555981 499231 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the interferon (IFN)-alpha , , interleukin-6 (IL-6) , and [tumor necrosis factor-alpha (TNF-alpha)] *response* to NDV but not to Sendai virus . Regulation TNF IFNB1 9667590 518610 In vitro studies with myelin basic protein (MBP)-specific T-cell lines revealed a synergistic suppressive *effect* of and the phosphodiesterase inhibitor pentoxifylline (PTX) on proliferation and the production of [tumor necrosis factor-alpha (TNF-alpha)] , lymphotoxin ( LT ) , and interferon-gamma (IFN-gamma) . Regulation TNF IFNG 10329109 613020 DHA inhibits macrophage stimulated NO production in *response* to and [TNF-alpha] . Regulation TNF IFNG 10374812 623132 Opposite *effects* of and prostaglandin E2 on [tumor necrosis factor] and interleukin-10 production in microglia : a regulatory loop controlling microglia pro- and anti-inflammatory activities . Regulation TNF IFNG 10534550 562756 The enhanced production of [TNF-alpha] by ibandronate treated PBMC in vitro *involves* stimulation of adherent monocytes by prior to LPS induced activation . Regulation TNF IFNG 10614780 575747 *Role* of on dissociation between nitric oxide and [TNF/IL-6] production by murine peritoneal cells after restimulation with bacterial lipopolysaccharide . Regulation TNF IFNG 10691318 670603 Moreover , did not *affect* [TNF-alpha] plasma levels . Regulation TNF IFNG 10933609 720327 In the present study , we investigated the regulatory *effects* of and/or PGE2 on LPS induced [TNF-alpha] production and mRNA expression in mouse peritoneal macrophages using the enzyme immunoassay and Northern blot analysis , respectively . Regulation TNF IFNG 11298122 801861 However all the DC irrespective of origin were able to produce [TNF-alpha] , IL-6 , low levels of IL-12 ( p70 ) and NO in *response* to LPS plus . Regulation TNF IFNG 12085313 958979 To study the effect of preexisting T cell responses to DV on the severity of secondary virus infection , peripheral blood mononuclear cells ( PBMC ) from 10 subsequently hospitalized and 12 nonhospitalized Thai schoolchildren were stimulated with inactivated dengue antigens , and proliferation of or [tumor necrosis factor (TNF)-alpha] *responses* of the preinfection PBMC were measured . Regulation TNF IFNG 12207333 983613 The fact that antibodies to IFN-gamma also inhibit AgICD suggests that the perforin plus granzyme independent and FaSL and/or [TNF-alpha] facilitated process of AgICD of T effector cells is tightly *regulated* by endogenous . Regulation TNF IFNG 12244188 990592 Whereas [TNF-alpha] production was normally up-regulated in *response* to , IL-12 production and CD64 up-regulation were strongly reduced , and IFN-gamma mediated killing of the intracellular pathogens Salmonella typhimurium and T. gondii was completely abrogated in patient 's macrophages . Regulation TNF IFNG 12498767 1026399 Ad-IL-10 transduced bone-marrow derived macrophages ( BMDM ) produced large amounts of IL-10 in culture , and their [TNF-alpha] production was decreased in *response* to and LPS . Regulation TNF IFNG 12517728 1028007 However , no *effect* of anti-IL-12 or on production of [TNF] , a cytokine with an important pathogenic role in Crohn 's disease , could be found . Regulation TNF IFNG 12537690 1034148 An exaggerated production of [TNF-alpha] has been reported in murine viral infections , in which mice become sensitized to low amounts of LPS and both and IFN-alpha/beta are *involved* in the macrophage induced release of TNF-alpha . Regulation TNF IFNG 12600410 1062213 It has been shown that *plays* a role in the regulation of interleukin-8 (IL-8) , nitric oxide ( NO ) , and [tumor necrosis factor-alpha (TNF-alpha)] secretion by macrophages stimulated with lignin derivatives , such as EP3 , and lipopolysaccharides (LPS) [ Cytokine 11 ( 1999 ) 571 ] . Regulation TNF IFNG 12600410 1062219 *Effects* of on [TNF-alpha] secretion by stimulated macrophages may be mediated by a different mechanism . Regulation TNF IFNG 1334048 205823 These results suggest that both IL-1 and [TNF] are the major cytokines affecting the EC functions that determine the association between the coagulation and the inflammatory response , and that *affects* this phenomenon predominantly through the modification of the effects of these cytokines . Regulation TNF IFNG 1353987 192653 IL-4 , IL-6 , GM-CSF and had no *effect* on [TNF-alpha] production by T cells activated via either pathway . Regulation TNF IFNG 1401365 199540 *Effect* of on the production of [tumor necrosis factor] during acute Escherichia coli mastitis . Regulation TNF IFNG 1401365 199541 The *effects* of recombinant on the production of [tumor necrosis factor] in 10 dairy cows with Escherichia coli mastitis were determined . Regulation TNF IFNG 15123153 1242356 Our preliminary findings suggest that immunity against FIP is associated with TNF-alpha and IFN-gamma response imbalance , with high [TNF-alpha/low] mRNA *responses* favouring disease and low TNF-alpha/high IFN-gamma mRNA responses being indicative of immunity . Regulation TNF IFNG 1527422 199901 only pentoxifylline blocked the priming *effect* of on [TNF] release . Regulation TNF IFNG 15466213 1305423 In this study , we have investigated the *role* of endogenous on the antitumor activity of [NGR-TNF] in combination with doxorubicin . Regulation TNF IFNG 15699106 1372391 Furthermore , pretreatment of murine macrophages with pamidronate before stimulation with IFN-gamma significantly augments *dependent* production of [TNF-alpha] . Regulation TNF IFNG 15790519 1386376 The synergistic *effect* of phytohemagglutinin and on the expression of [tumor necrosis factor-alpha] from RAW 264.7 cells . Regulation TNF IFNG 15790519 1386377 The aim of this study was to examine the synergistic *effects* of PHA plus low dose on [TNF-alpha] mRNA production , cytosolic levels , and secretion in RAW 264.7 cells . Regulation TNF IFNG 15790519 1386378 Although the TNF-alpha mRNA production , cytosolic levels , and secretion from the cells were slightly detected under 10 microg/ml PHA and 1 ng/ml IFN-gamma , the combination of PHA ( 10 microg/ml ) and IFN-gamma ( 1 ng/ml ) greatly increased them , indicating the synergistic *effect* of PHA plus low dose on [TNF-alpha] expression . Regulation TNF IFNG 16177125 1458047 The anti-IFN-gamma IgG had in vitro biological activity on the *dependent* phosphorylation of STAT-1 as well as on the IFN-gamma dependent up-regulation of [TNF-alpha] and IL-12 . Regulation TNF IFNG 16181054 1461877 We also investigated the *effect* of on the release of [TNF-alpha] by these cells . Regulation TNF IFNG 1639488 194650 Our results demonstrate that TNF production by macrophages is altered during E. histolytica infection and in response to amoebae and suggest a *role* for and prostaglandin E2 in regulating [TNF] production during the infection . Regulation TNF IFNG 16487932 1528520 Herein we report that the repressible/inducible over-expression of wild-type SHP-1 in a subclone of RAW 264.7 macrophages ( RAW-TT10 cells ) inhibited both [TNF] secretion and iNOS protein accumulation in *response* to stimulation with lipopolysaccharide (LPS) and recombinant murine and led to diminished LPS mediated tyrosine phosphorylation of vav1 . Regulation TNF IFNG 16580226 1550183 Treatment of monoclonal antibodies against cytokines showed that and interleukin 10 (IL-10) were involved in maintenance of growth of S. Typhimurium mutant on day 10 after infection , and IFN-gamma , [TNF-alpha] and transforming growth factor-beta ( TGF-beta ) were *involved* in maintenance of growth of this bacterium on day 30 after infection . Regulation TNF IFNG 16931033 1627261 The expression of interferon responsive factor (IRF)-1 , an IFN-gamma induced transcriptional activator critical to IDO regulation , is also enhanced synergistically in *response* to and [TNF-alpha] . Regulation TNF IFNG 1697308 139525 In our study , we have further examined *effects* on both [TNF] and IL-1 beta responses . Regulation TNF IFNG 17035338 1674561 Taken together , our data suggest that the [TNF-alpha] produced in *response* to is required for iNOS induction by activating NF-kappaB transcription factor . Regulation TNF IFNG 17520688 1784059 Cultured human mesangial cells ( HMCs ) expressed C3 mRNA and protein , and levels were increased in *response* to and [TNF-alpha] . Regulation TNF IFNG 18390706 1893273 The *effect* of on [TNF-alpha] expression was durable upon cytokine washout and even repolarization with IL-4 . Regulation TNF IFNG 1846894 153368 These studies showed that the number of [TNF] receptors increased on macrophages vs maturation in culture and was negatively *controlled* by . Regulation TNF IFNG 18506884 1928274 PGE ( 2 ) counters the *effects* of , on the release of IP-10 , IL-8 , [TNF-alpha] and IL-1beta . Regulation TNF IFNG 1904523 159354 In this study , we examined the *effect* of in vitro Kupffer cell activation by recombinant murine on IL-1 and [TNF] secretion . Regulation TNF IFNG 1906383 161706 The *effects* of GM-CSF , IL-2 , , TNF-alpha and IL-6 on the production of IL-1 ( both secreted and cell associated ) and [TNF-alpha] by peripheral blood monocytes were studied . Regulation TNF IFNG 19291774 2086832 Both and TNFalpha are important in this injury process , but [TNFalpha] *acts* as an autocrine amplifier of Kupffer cell function , rather than as a direct effector of hepatocellular damage . Regulation TNF IFNG 19375139 2074700 A positive correlation was observed between the growth indices ( GI ) of H37Rv , Beijing and CAS1 strains and the [TNF-alpha] *responses* they induced [ Pearson 's correlation coefficient ( R ( 2 ) ) : 0.936 , 0.775 and 0.55 , respectively ] , and also between GI and production ( R ( 2 ) : 0.422 , 0.946 , 0.674 ) . Regulation TNF IFNG 20637124 2304614 This M1-M2 switch was shown by a decreased expression of CD80 upon LPS/IFNgamma stimulation , an increased secretion of IL-10 , a decreased secretion of [TNFalpha] in *response* to and an inability to potentiate apoptosis . Regulation TNF IFNG 2108965 131120 IL-2 alone did not induce the expression of either gene while or IFN beta had a modest inductive effect on IP-10 but no *effect* on [TNF alpha] expression . Regulation TNF IFNG 2120285 141920 In an effort to understand what other mechanisms might play a role in the patient with sepsis , we examined the *effect* of on the synthesis of [cachectin/TNF] . Regulation TNF IFNG 2120581 141925 Therefore , we investigated the *effect* of interferon-alpha (IFN-alpha) , and tumor necrosis factor ( TNF-alpha ) on the induction of LAK activity by IL-2 , and the induction of IFN-gamma and [TNF-alpha] by IL-2 . Regulation TNF IFNG 2165948 137864 Furthermore , the secretion of [TNF-alpha] in *response* to and LPS is almost absent in macrophages from aged rats . Regulation TNF IFNG 2509302 120463 The *effect* of on [TNF] receptors was also examined . Regulation TNF IFNG 2787351 114838 The potentiating *effect* of on LPS induced [TNF] secretion ( 15.3 +/- 0.7 to 44 +/- 0.6 ng/ml ) was also blocked by anti-class II ag mAb ( 44 +/- 0.6 to 0.3 +/- 0.03 ng/ml ) . Regulation TNF IFNG 3007500 57393 [Tumor necrosis factor] receptors in HeLa cells and their *regulation* by . Regulation TNF IFNG 3045826 97122 We also demonstrated that the [IL-2/TNF] synergistic induction of LAK activity did not *involve* either IL-1 or . Regulation TNF IFNG 3131488 83453 The present study was undertaken to examine the *effect* of recombinant human ( rHu-IFN-gamma ) on the in vitro antitumor activity of recombinant human tumor necrosis factor ( [rHu-TNF] ) against rHu-TNF-sensitive and resistant tumor cells . Regulation TNF IFNG 3141050 99676 The *effect* of recombinant human ( rHu-IFN-gamma ) on the antitumor activity of recombinant human tumor necrosis factor ( [rHu-TNF-alpha] ) was examined in vitro and in vivo . Regulation TNF IFNG 7595061 334843 Northern blotting studies revealed no *effect* of alone on IL-1 beta or [TNF-alpha] mRNA production . Regulation TNF IFNG 7693830 234234 We found that cell lines that are sensitive to [TNF mediated cytotoxicity (TMC)] produced NO in *response* to TNF and , but not in response to IFN-alpha beta . Regulation TNF IFNG 7962479 279381 Constitutive production of the cytokine [TNF] , or its liberation in *response* to either or lipopolysaccharide (LPS) alone , was very low in RMG and RPE cells , irrespective of the strain . Regulation TNF IFNG 8049441 267469 Likewise , maximal uPA binding capacity was increased 2.8-fold by ( P < .02 ) , but was not *affected* by [TNF alpha] . Regulation TNF IFNG 8063414 268743 These data suggest that both cytokines act in an additive or synergistic fashion in the induction of bacteriostasis and that is also *involved* in priming [TNF-alpha] secretion . Regulation TNF IFNG 8632057 357226 Basal expression of ICAM-1 molecules was enhanced by [TNF alpha] and to a lesser extent by IFN-beta , but was not *affected* by . Regulation TNF IFNG 8645988 363344 *Regulation* of mRNA levels of [TNF-alpha] and the alpha chain of the high-affinity receptor for IgE in mast cells by and alpha/beta . Regulation TNF IFNG 8675208 369797 Thus and IL-4 may differentially *affect* the post-transcriptional control of [TNF-alpha] gene expression . Regulation TNF IFNG 8742066 377136 The *effects* of LPS and on [TNF-alpha] and sTNF-R75 release were progressively lost with increasing time in culture in the presence of IL-4 . Regulation TNF IFNG 8843212 387367 Earlier and stronger interleukin (IL)-12 , , and [tumor necrosis factor] *responses* were found in Borrelia burgdorferi infected , vitamin A-deficient mice compared with controls . Regulation TNF IFNG 8906830 394398 These data suggest that the aggregate IL-12 p40 and p70 response to endotoxemia in vivo is IFN-gamma independent and distinct from *dependent* serum [TNF-alpha] and splenic IL-12 responses . Regulation TNF IFNG 9133389 426968 We determined whether endogenous could be *responsible* for the observed increases in IL-1 and [TNF-alpha] , because IFN-gamma is a potent microglia/macrophage activator , and because its exogenous administration to rodents enhanced astrogliosis after adult or neonatal insults . Regulation TNF IFNG 9164938 432134 RelB binds transcriptionally active kappaB motifs in the TNF-alpha promoter in normal cells , and in vitro studies with macrophages isolated from RelB-deficient animals revealed impaired production of [TNF-alpha] in *response* to LPS and . Regulation TNF IFNG 9354687 461667 We also compared the *effects* of and IL-10 on production of [TNF-alpha] and sTNF-RII by these cells . Regulation TNF IFNG 9520166 493484 Concerning PBMC , the production of [TNF-alpha] and IL-12 in *response* to LPS , or LPS plus , was found to be significantly higher in cells isolated from HIV positive patients , whereas the release of IL-1beta was significantly lower . Regulation TNF IFNG 9536945 497503 In contrast , had no significant *effect* on [TNF-alpha] stimulated IL-8 secretion . Regulation TNF IFNG 9555975 499216 We previously demonstrated that iNOS can be induced in cultured bovine monocytes in *response* to and [TNF-alpha] but lose this capability in a short period of time . Regulation TNF IFNG 9795804 543429 did not *affect* LPS induced [TNF-alpha] and MCP-1 production , but increased baseline MCP-1 production . Regulation TNF IFNG 9806040 544645 These patients demonstrate the critical role that the receptor *plays* in the regulation of IFN-gamma , IL-12 , and [TNF-alpha] . Regulation TNF IGF1 11408113 825896 To further elucidate the role and mechanism of action of TNFalpha on ovarian cells , the effect of TNFalpha on insulin-like growth factor-I (IGF-I) induced steroidogenesis and binding sites in granulosa and thecal cells as well as the hormonal *regulation* of [TNFalpha] receptors were evaluated . Regulation TNF IGF1 8895324 392459 Preexposure of macrophages with specific antibodies against IGF-I and IGF-I receptor before IGF-I addition resulted in a complete abrogation of the stimulatory *effect* of on [TNF alpha] production , indicating that specific binding of IGF-I to its receptor is required for macrophage TNF alpha induction by IGF-I . Regulation TNF IGF1 8895324 392466 Addition of these compounds resulted in a dose dependent inhibition of the stimulatory *effect* of on macrophage [TNF alpha] release , indicating that protein tyrosine kinase activation is required for TNF alpha stimulation by IGF-I . Regulation TNF IGKV1-27 8557994 348691 Overexpression of does not *affect* the binding of [TNF] to its cell surface receptors . Regulation TNF IKBKB 11124824 768967 We analyzed the differential *role* of I kappa B kinase 1 (IKK1) and in [tumor necrosis factor alpha (TNF-alpha)-] and interleukin-1 beta (IL-1 beta) mediated NF-kappa B activation in primary rat hepatocytes . Regulation TNF IKBKB 12847684 1109036 To investigate the potential *role* of IkappaB kinase 1 (IKK-1) and in the regulation of nuclear factor kappaB (NF-kappaB) activation and the expression of [tumor necrosis factor alpha (TNFalpha)] , as well as interleukin-1beta (IL-1beta) , IL-6 , IL-8 , vascular endothelial growth factor ( VEGF ) , and matrix metalloproteinases ( MMPs ) , in rheumatoid arthritis ( RA ) . Regulation TNF IKBKE 16199137 1531968 The data suggest that is not *involved* in [TNF-alpha] mediated signaling but instead could likely play a role in activating IKK2 downstream of Toll-like receptor signaling . Regulation TNF IKBKG 17702576 1782966 Optineurin negatively *regulates* [TNFalpha-] induced NF-kappaB activation by competing with for ubiquitinated RIP . Regulation TNF IKBKG 22513115 2602009 differentially *regulates* TCR and [TNF-a] induced NF-?B pathways and has an inhibitory role in TCR induced NF-?B activation . Regulation TNF IL10 10452106 637588 Both endogenous and exogenous nitric oxide and had inhibitory *effects* on the LPS induced [TNF alpha] , IL-1 beta , and IL-6 secretions in mouse AM . Regulation TNF IL10 10453017 637886 To test this hypothesis , we used bronchoalveolar lavage cells from control and CBD subjects to evaluate the beryllium salt-specific production of endogenous and the *effects* of exogenous human rIL-10 ( rhIL-10 ) on HLA expression , on the production of IL-2 , IFN-gamma , and [TNF-alpha] , and on T lymphocyte proliferation . Regulation TNF IL10 10484681 626362 Here we investigated the *effect* of endogenous on [TNF-alpha] production in purified lipopolysaccharide (LPS) stimulated monocytes and its mechanism . Regulation TNF IL10 10484681 626364 While blockade of endogenous IL-10 binding to the IL-10 receptor enhanced the autocrine production of TNF-alpha , IL-12 and IL-1 beta , the neutralization of IL-12 or IL-1 beta did not affect the *effects* on [TNF-alpha] production . Regulation TNF IL10 10542212 563697 Conflicting data exists on the *effects* of on [TNF-] and LPS induced NF-kappaB activity in human monocytes and the molecular mechanisms involved have not been elucidated . Regulation TNF IL10 10880238 709102 Two distinct tyrosine kinase inhibitors , herbimycin and genistein affected the expression of [TNF-R] in *response* to but , surprisingly , with opposite effects . Regulation TNF IL10 10947160 721905 The *role* of on the [TNF] response and survival was examined in a subset of mice given mouse anti IL-10 IgM ( 25 mg/kg intraperitoneally ) 2 h prior to the initial insult . Regulation TNF IL10 10969796 728402 decreased the production of IL-6 and the expression of IL-12 in the presence of TNF-alpha or sCD40L , but it had no *effect* on IL-15 , IL-18 , and [TNF-alpha] secretion . Regulation TNF IL10 11008981 735850 Left atrial femoral bypass significantly reduced the duration of visceral ischemia ( p < .05 ) and the systemic [TNF-alpha] , p75 , and *responses* ( p < .05 ) . Regulation TNF IL10 11012758 736157 Because is *involved* in the UV-induced suppression of delayed-type hypersensitivity and [TNF-alpha] in the UV-induced suppression of contact allergy , these findings provide a mechanism to explain how rIL-12 overcomes UV-induced immune suppression in these related but different immune reactions . Regulation TNF IL10 11052826 743476 High plasma levels at diagnosis of ALL had no *effect* on the ex vivo [TNF-alpha] and IL-1beta production of monocytes in LPS stimulated MNC cultures . Regulation TNF IL10 11083779 750520 To understand the mechanism ( s ) of IL-10 action during early infection , when innate immunity expressed chiefly by skin macrophages is key , we investigated the *effect* of exogenous and endogenous on the production of the macrophage derived cytokines IL-6 , IL-1beta , IL-12 , and [tumor necrosis factor alpha (TNF-alpha)] . Regulation TNF IL10 11469886 840940 We examined the *role* of endogenous in the regulation of NF-kappaB activation and [TNF-alpha] production in human monocytes by cAMP . Regulation TNF IL10 11875494 918916 Inhibition of HO-1 protein synthesis or activity significantly reversed the inhibitory *effect* of on production of [tumor necrosis factor-alpha] induced by lipopolysaccharide (LPS) . Regulation TNF IL10 12142967 969596 Yoghurt increased the number of apoptotic cells and induced IFN-gamma and [TNF-alpha] cytokine release , their production being *regulated* by an increase in ( P < 0.001 ) . Regulation TNF IL10 12161227 971918 *Effect* of on the production of [tumor necrosis factor-alpha] by peripheral blood mononuclear cells from patients with chronic heart failure . Regulation TNF IL10 12163148 972314 *plays* a critical role in the modulation of [TNF] production , and IL-10 may inhibit hepatic fibrosis . Regulation TNF IL10 12535207 1049429 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL10 12566670 1029409 In the HD patients , there was an inverse correlation between TNF-alpha and IL-10 synthesis by ET-stimulated PBMC , suggesting a regulatory *effect* of on PBMC [TNF-alpha] synthesis . Regulation TNF IL10 12759436 1091172 In IL-10R1 G330R expressing monocytes , the inhibitory *effect* of on [TNF-alpha] production was diminished , indicating that this variant may be a loss-of-function allele . Regulation TNF IL10 14675562 1189372 We compared the *effects* of and anti IL-12 antibody ( Ab ) on [TNF-alpha] production and oxidative stress markers . Regulation TNF IL10 14977992 1213344 Mycobacterial purified protein derivatives stimulate innate immunity : Malawians show enhanced [tumor necrosis factor] alpha , interleukin-1beta (IL-1beta) , and *responses* compared to those of adolescents in the United Kingdom . Regulation TNF IL10 14977992 1213348 To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom , we examined 24-h [tumor necrosis factor] alpha , interleukin-1beta (IL-1beta) , and *responses* to mycobacterial purified protein derivatives ( PPDs ) . Regulation TNF IL10 15325406 1287144 The second objective was to assess *effects* of human recombinant on interleukin-6 (IL-6) and [tumour necrosis factor-alpha (TNF-alpha)] responses of human leukocytes to staphylococcal toxins implicated in SIDS . Regulation TNF IL10 15361231 1293653 IFN-gamma and [TNF-alpha] play a role in both protective immunity and the pathology of the infection , and the inflammatory disease may be *regulated* by and transforming growth factor-beta . Regulation TNF IL10 1598496 188882 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL10 16369191 1505146 These results suggest that FN protected against GalN/LPS induced liver failure by a mechanism involving inhibition of NF-kappaB activation , which caused down-regulation of [TNF-alpha] and *involved* up-regulation of , and elevation of Bcl-xL induced a blockage of apoptotic signals , by which apoptosis of hepatocytes caused by GalN/LPS was suppressed . Regulation TNF IL10 16580226 1550184 Treatment of monoclonal antibodies against cytokines showed that IFN-gamma and were involved in maintenance of growth of S. Typhimurium mutant on day 10 after infection , and IFN-gamma , [TNF-alpha] and transforming growth factor-beta ( TGF-beta ) were *involved* in maintenance of growth of this bacterium on day 30 after infection . Regulation TNF IL10 16925527 1603314 When data from all donors were combined , adenoviral overexpression of SOCS3 significantly reversed the suppressive *effects* of on LPS induced [TNF-alpha] production after 2 hr . Regulation TNF IL10 16935932 1627399 Detailed studies on *regulation* of [TNF-alpha] mRNA expression identified AU-rich elements ( ARE ) in the 3 ' untranslated region as a necessary determinant of IL-10 mediated TNF-alpha mRNA destabilization . Regulation TNF IL10 17464085 1766489 Moreover , limiting dilution transplantation assay demonstrated that exogenous addition of IL-10 in the stroma-free cultures of purified Lin- Sca-1+ c-kit+ cells caused three- to fourfold higher frequencies of HSCs in the 5-day short-term culture without indirect inhibitory *effect* of on [tumor necrosis factor-alpha] or interferon-gamma secretion . Regulation TNF IL10 17584982 1815867 In this work , we studied the role of changes in norepinephrine ( NE ) level on the lipopolysaccharide (LPS) evoked [tumor necrosis factor (TNF)-alpha] and *response* both in the plasma and in the hippocampus of mice . Regulation TNF IL10 18218915 1890336 *Effects* of and age on IL-6 , IL-1beta , and [TNF-alpha] responses in mouse skeletal and cardiac muscle to an acute inflammatory insult . Regulation TNF IL10 19596777 2122960 These results suggest that GSK-3beta *regulates* heat inactivated S. aureus induced [TNF-alpha] and NO production in microglia mainly by activating NF-kappaB and probably by inhibiting . Regulation TNF IL10 20180418 2180828 To study the efficacy of in the treatment of experimental autoimmune prostatitis ( EAP ) and its *effect* on the expressions of [tumor necrosis factor-alpha (TNF-alpha)] and transforming growth factor-beta1 ( TGF-beta1 ) in EAP rat models . Regulation TNF IL10 21533451 479108 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL10 21809216 2484802 however , had no *effect* on IFN-? or [TNF-a] production or NK cell activatory receptor expression . Regulation TNF IL10 22219323 2544468 In this study , we have compared the mechanisms involved in mediated [TNF-a] *regulation* in LPS stimulated macrophages with macrophages stimulated with activated T cells . Regulation TNF IL10 22219323 2544470 These observations have very important implications for our understanding as to how *regulates* [TNF-a] production at sites of chronic inflammation , such as the synovial tissue of patients with RA . Regulation TNF IL10 22693231 2638681 Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß) , interleukin 6 (IL-6) , , interleukin 12 (IL-12) , and [tumor necrosis factor a (TNF-a)] *responses* to Toll-like receptor (TLR) 3 and TLR4 stimulation . Regulation TNF IL10 23432860 2744428 These results suggest that the high circulating [TNF-alpha] levels and the inadequate *response* in the SM patients carrying TNF2 allele could have contributed to the development of severe falciparum malarial disease . Regulation TNF IL10 23509800 2756984 Overexpression of could be *responsible* for the Map associated reduction in the expression of the proapoptotic [TNF-a] gene observed in bovine and human macrophages . Regulation TNF IL10 23731227 2819798 The best characterized *effects* of are anti-inflammatory-it downregulates pro-inflammatory species interleukin-1ß (IL-1ß) , interleukin-2 (IL-2) , interleukin-6 (IL-6) , [tumor necrosis factor-a] , interferon-? , matrix metalloproteinase-9 , nitric oxide synthase , myeloperoxidase , and reactive oxygen species . Regulation TNF IL10 24485388 2918529 IL-10 might have a protective role , since the neutralization of IFN-? decreases the production of [TNF-a] in an *dependent* manner . Regulation TNF IL10 2471522 111751 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL10 2788284 116845 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL10 7540642 310123 Seven-day cultured monocytes/macrophages showed ( 1 ) diminished [TNF-alpha] production in *response* to but not IL-4 ( 2 ) , diminished IL-1 beta production in response to both IL-4 and IL-10 , and compared with fresh monocytes ( 3 ) , diminished CD14 expression in response to IL-4 , and ( 4 ) a lesser increase in CD23 expression in response to IL-4 . Regulation TNF IL10 7578738 333346 Since *controls* the production of [tumor necrosis factor alpha (TNF-alpha)] and this latter cytokine has a deleterious effect on neuronal cells , we determined the levels of both cytokines in cerebrospinal fluid (CSF) from children with bacterial meningitis . Regulation TNF IL10 7604878 311720 As shown by the use of anti-IL-10 monoclonal antibody , endogenously produced *affected* the generation of [TNF-alpha] but neither that of IL-1 beta nor that of NO2- and NO3- . Regulation TNF IL10 7737695 288901 The regulatory mechanisms so far known to control NO synthesis include cytokines ( induction of NO synthase by IFN-gamma , [TNF alpha] , MIF and LPS , and down *regulation* by IL-4 , and TGF beta ) , feedback inhibition by NO itself , inhibition by pretreatment with LPS and glycoinositol-phospholipids and up regulation by lipophosphoglycan from the protozoa parasite , Leishmania major . Regulation TNF IL10 7790026 313166 Because and IL-4 differentially *regulate* [TNF-alpha] and IL-1ra production by synovial fluid mononuclear cells , selective use of either IL-10 or IL-4 in the treatment of chronic inflammatory conditions will depend on whether TNF-alpha or IL-1 , respectively , is established as primarily responsible for the maintenance of the chronic inflammatory condition . Regulation TNF IL10 7957562 278062 We , therefore , investigated the *effects* of and IL-4 on the cell surface expression and release of [TNF-R] by human monocytes to determine whether these cytokines also indirectly modulated the biological activity of TNF-alpha . Regulation TNF IL10 7986155 282325 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL10 8613550 353559 Whereas the in vivo regulatory effects of IL-1R appear to be limited to IL-1beta , *regulates* both IL-1beta and [TNF-alpha] in this model , reflected by a 48 % increase in BAL IL-1beta in rats treated with anti-IL-10 . Regulation TNF IL10 8646564 343023 did not *affect* the LPS induced increase of serum corticosterone , the main endogenous inhibitor of [TNF] production , or the induction of IL-6 . Regulation TNF IL10 8704096 371125 Our data demonstrate that IL-1 alpha and [TNF-alpha] release by AMs is down *regulated* by IL-4 , , and TGF-beta . Regulation TNF IL10 8711645 371304 *regulation* of [tumour necrosis factor alpha (TNF-alpha)] from human alveolar macrophages and peripheral blood monocytes . Regulation TNF IL10 8711645 371305 The *effects* of on [TNF-alpha] protein production were determined by sandwich enzyme linked immunosorbant assay ( ELISA ) , whereas the TNF-alpha mRNA response was established by Northeren blotting using a TNF-alpha specific oligonucleotide probe . Regulation TNF IL10 8711645 371308 mRNA stability experiments indicated no acceleration in lipopolysaccharide induced [TNF-alpha] mRNA degradation in *response* to . Regulation TNF IL10 8835203 386084 Interleukin 1 beta , interleukin 6 , [tumor necrosis factor] alpha , and *responses* in peripheral blood mononuclear cells of cynomolgus macaques during acute infection with SIVmac251 . Regulation TNF IL10 8871669 389620 *Regulation* of surface and soluble [TNF] receptor expression on human monocytes and synovial fluid macrophages by IL-4 and . Regulation TNF IL10 8921945 396868 was in turn partly *responsible* for a reduction in [tumor necrosis factor-alpha] synthesis . Regulation TNF IL10 9029140 413604 Changes in surface [TNF] receptor expression on circulating granulocytes were not *affected* by . Regulation TNF IL10 9336412 458165 was *responsible* for the suppression of IFN gamma and [TNF alpha] , as judged by the effect of adding either anti-IL-10 antibodies or exogenous IL-10 to these cultures . Regulation TNF IL10 9350293 460846 Since production of both IL-6 and [TNF-alpha] is *regulated* by , the enhancement of the production of these cytokines could reflect a defect in either IL-10 production or responsiveness . Regulation TNF IL10 9354687 461666 however , the *effects* of on [TNF receptor (TNF-R)] expression are not well defined . Regulation TNF IL10 9354687 461668 We also compared the *effects* of IFN-gamma and on production of [TNF-alpha] and sTNF-RII by these cells . Regulation TNF IL10 9369823 464073 This study suggests that and transforming growth factor-beta can *regulate* [tumor necrosis factor-alpha] release from amniochorion under different conditions and by a different mechanism . Regulation TNF IL10 9373262 464794 These data suggest that endogenous can *regulate* activated T-cell production of IFN-gamma and [TNF-alpha] via a paracrine negative feedback loop . Regulation TNF IL10 9587398 504608 Moreover , this inhibitory *effect* of was not simply attributable to its inhibition of [TNF-alpha] production in LPS stimulated monocytes . Regulation TNF IL10 9679667 520856 Transgenic expression of cytokines in beta-cells of non-diabetes-prone mice and NOD mice has suggested pathogenic roles for IFN alpha , IFN gamma , IL-2 and in insulin dependent diabetes mellitus ( IDDM ) development , and protective *roles* for IL-4 , IL-6 and [TNF alpha] . Regulation TNF IL10 9697984 524821 We examined the *effects* of on [tumour necrosis factor-alpha (TNF-alpha)] and NO production by LPS activated macrophages and on the ability of these cells to control Trypanosoma cruzi infection . Regulation TNF IL10 9872676 556923 The purpose of this study was to determine the *effect* of on lipopolysaccharide (LPS) induced human monocyte [TNF-alpha] production , NF-kappaB activation , and IkappaB-alpha degradation . Regulation TNF IL11 12535207 1049430 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL11 1598496 188883 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL11 21533451 479109 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL11 2471522 111752 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL11 2788284 116846 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL11 7986155 282326 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL12A 10427983 633052 When the antibodies were added to synovial cells from arthritic mice and bone marrow macrophages in vitro , anti-TNF diminished IL-12 production , but had no *effect* on [TNF] production . Regulation TNF IL12A 12516635 1027886 We further investigated the *effect* of recombinant human ( rh ) on the production of interferon (IFN)-gamma and [tumor necrosis factor (TNF)-alpha] in peripheral leukocytes ex vivo . Regulation TNF IL12A 12517728 1028008 However , no *effect* of or anti-IFN-gamma on production of [TNF] , a cytokine with an important pathogenic role in Crohn 's disease , could be found . Regulation TNF IL12A 15002060 1217166 is *involved* in regulation of IFNgamma and [TNFalpha] . Regulation TNF IL12A 16830103 1586772 Finally , isolated Kupffer cells produced [TNFalpha] in *response* to IL-23 , but not , suggesting that IL-23 may be the relevant initiator of the hepatic inflammatory response to ischemia/reperfusion . Regulation TNF IL12A 17523872 1746090 Here , we investigated the *role* of on nitric oxide ( NO ) and [tumor necrosis factor-alpha (TNF-alpha)] production by CD11b ( + ) adherent peritoneal cells , focusing on the involvement of endogenously produced IFN-gamma . Regulation TNF IL12A 17893129 1823885 Cytokine analysis was performed on infected peritoneal macrophages isolated from these mice , and immunocompetent macrophages showed robust [tumor necrosis factor] alpha , IFN-gamma , and granulocyte-macrophage colony stimulating factor ( GM-CSF ) but no *responses* . Regulation TNF IL12A 21670312 2451209 Finally , there is a strong synergy between calcium depletion in the ER and sterile IL-6 , as well as LPS dependent IL-1ß , , IL-23 , and [TNF-a] innate *responses* , findings that have implications for understanding inflammatory diseases that originate in the ER . Regulation TNF IL12A 22693231 2638682 Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß) , interleukin 6 (IL-6) , interleukin 10 (IL-10) , , and [tumor necrosis factor a (TNF-a)] *responses* to Toll-like receptor (TLR) 3 and TLR4 stimulation . Regulation TNF IL12A 7786778 309982 The *effects* of on natural killer ( NK ) cell cytotoxicity and on the production of interferon-gamma (IFN-gamma) and [tumour necrosis factor-alpha (TNF-alpha)] were examined in 15 patients with myelodysplastic syndromes (MDS) , which are well known to have immunologic defects , and in 11 normal subjects . Regulation TNF IL12A 7907529 250407 The 55-kDa [TNF] receptor ( TNF-R p55 ) , however , was not *affected* by , but in the presence of anti-IFN-gamma antibody , its expression was enhanced . Regulation TNF IL12A 8843212 387368 Earlier and stronger , interferon-gamma (IFN)-gamma , and [tumor necrosis factor] *responses* were found in Borrelia burgdorferi infected , vitamin A-deficient mice compared with controls . Regulation TNF IL12A 9711774 526983 Furthermore , we have studied the *effects* of and IL-15 on induction of IFN-gamma and [TNF-alpha] production , NK , and LAK activities in CB and APB . Regulation TNF IL12B 10427983 633053 When the antibodies were added to synovial cells from arthritic mice and bone marrow macrophages in vitro , anti-TNF diminished IL-12 production , but had no *effect* on [TNF] production . Regulation TNF IL12B 12516635 1027887 We further investigated the *effect* of recombinant human ( rh ) on the production of interferon (IFN)-gamma and [tumor necrosis factor (TNF)-alpha] in peripheral leukocytes ex vivo . Regulation TNF IL12B 12517728 1028009 However , no *effect* of or anti-IFN-gamma on production of [TNF] , a cytokine with an important pathogenic role in Crohn 's disease , could be found . Regulation TNF IL12B 15002060 1217167 is *involved* in regulation of IFNgamma and [TNFalpha] . Regulation TNF IL12B 16830103 1586773 Finally , isolated Kupffer cells produced [TNFalpha] in *response* to , but not IL-12 , suggesting that IL-23 may be the relevant initiator of the hepatic inflammatory response to ischemia/reperfusion . Regulation TNF IL12B 17523872 1746091 Here , we investigated the *role* of on nitric oxide ( NO ) and [tumor necrosis factor-alpha (TNF-alpha)] production by CD11b ( + ) adherent peritoneal cells , focusing on the involvement of endogenously produced IFN-gamma . Regulation TNF IL12B 17893129 1823886 Cytokine analysis was performed on infected peritoneal macrophages isolated from these mice , and immunocompetent macrophages showed robust [tumor necrosis factor] alpha , IFN-gamma , and granulocyte-macrophage colony stimulating factor ( GM-CSF ) but no *responses* . Regulation TNF IL12B 21670312 2451210 Finally , there is a strong synergy between calcium depletion in the ER and sterile IL-6 , as well as LPS dependent IL-1ß , , IL-23 , and [TNF-a] innate *responses* , findings that have implications for understanding inflammatory diseases that originate in the ER . Regulation TNF IL12B 22693231 2638683 Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß) , interleukin 6 (IL-6) , interleukin 10 (IL-10) , , and [tumor necrosis factor a (TNF-a)] *responses* to Toll-like receptor (TLR) 3 and TLR4 stimulation . Regulation TNF IL12B 7786778 309983 The *effects* of on natural killer ( NK ) cell cytotoxicity and on the production of interferon-gamma (IFN-gamma) and [tumour necrosis factor-alpha (TNF-alpha)] were examined in 15 patients with myelodysplastic syndromes (MDS) , which are well known to have immunologic defects , and in 11 normal subjects . Regulation TNF IL12B 7907529 250408 The 55-kDa [TNF] receptor ( TNF-R p55 ) , however , was not *affected* by , but in the presence of anti-IFN-gamma antibody , its expression was enhanced . Regulation TNF IL12B 8843212 387369 Earlier and stronger , interferon-gamma (IFN)-gamma , and [tumor necrosis factor] *responses* were found in Borrelia burgdorferi infected , vitamin A-deficient mice compared with controls . Regulation TNF IL12B 9711774 526984 Furthermore , we have studied the *effects* of and IL-15 on induction of IFN-gamma and [TNF-alpha] production , NK , and LAK activities in CB and APB . Regulation TNF IL13 10427971 633038 mRNA levels for IL-13R alpha1 , but not IL-4R alpha , were markedly decreased in in vitro monocyte derived macrophages ( MDMac ) , and with increasing time of monocytes in culture correlated with the loss of *regulation* of lipopolysaccharide induced [TNF-alpha] production . Regulation TNF IL13 12535207 1049431 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL13 1598496 188884 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL13 17455319 1865862 In vitro studies further demonstrate that both exogenous and T cell derived can *regulate* [TNFalpha] production by macrophages following lipopolysaccharide stimulation . Regulation TNF IL13 17458900 1772153 Administration of cell-permeable C8 ceramide reduced production of IL-5 , IL-10 , and from LPS stimulated mouse bone marrow derived mast cells ( BMMCs ) apparently through transcriptional inhibition , but did not *affect* IL-6 or [TNF-alpha] production . Regulation TNF IL13 17617590 1769629 IL-4 and negatively *regulate* [TNF-alpha-] and IFN-gamma induced beta-defensin expression through STAT-6 , suppressor of cytokine signaling (SOCS)-1 , and SOCS-3 . Regulation TNF IL13 21533451 479110 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL13 2471522 111753 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL13 2788284 116847 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL13 7986155 282327 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL13 8660851 371770 The inhibitory *effect* of IL-4 and on the release of [TNF alpha] was partially reversed by neutralizing anti-IL10 antibody , and the inhibition of IL-6 release was completely reversed by the antibody . Regulation TNF IL13 9099934 406406 The inhibitory *effect* of on [TNF-alpha] and IL-6 production in differentiated macrophages was diminished in IBD patients , as well as in controls . Regulation TNF IL13 9120298 423848 the fusion inducing *effects* of continued to be observed in the presence of neutralizing Abs to IL-4 and several other anti-cytokine Abs , including Abs against IFN-gamma , granulocyte-macrophage CSF , IL-3 , and [TNF-alpha] . Regulation TNF IL13 9743347 532422 The inhibitory *effects* of on [TNF] were sensitive to H-7 , neomycin , and wortmannin , suggesting that the pathway consisting of protein kinase C , phosphatidylinositol 3-kinase , and phospholipase C must be involved in IL-13 signaling . Regulation TNF IL15 12535207 1049432 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL15 1598496 188885 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL15 16251219 1483763 In addition , the expression of IL-15 receptor alpha ( IL-15Ralpha ) and membrane bound IL-15 was assessed and the in vitro *effects* of on CD69 and CD64 expression , interferon-gamma and [TNF-alpha] synthesis , respiratory burst induction and apoptosis were studied . Regulation TNF IL15 17045026 1635675 To investigate the *effect* of interleukin-7 and on the production of Th1 cytokines interferon-gamma (IFN-gamma) , [tumor necrosis factor-alpha (TNF-alpha)] and Th2 cytokines interleukin-4 (IL-4) , IL-10 by peripheral blood mononuclear cells ( PBMC ) from patients with tuberculosis . Regulation TNF IL15 18086532 1854764 In contrast , IL-8 and [TNF-alpha] levels were not *affected* by suggesting that its effects were not mediated by these cytokines . Regulation TNF IL15 18782269 1963272 Although its signal transduction pathways in keratinocytes ( KC ) have been partially elucidated , the *effects* of on expression of IL-15 , IL-6 and [TNF-alpha] in KC are unknown . Regulation TNF IL15 21533451 479111 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL15 2471522 111754 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL15 2788284 116848 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL15 7986155 282328 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL15 9711774 526985 Furthermore , we have studied the *effects* of IL-12 and on induction of IFN-gamma and [TNF-alpha] production , NK , and LAK activities in CB and APB . Regulation TNF IL16 12535207 1049433 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL16 1598496 188886 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL16 16178875 1458222 is *involved* in the regulation of the expression of several proinflammatory cytokines , i.e . [tumour necrosis factor (TNF)alpha] and interleukin (IL)-1beta . Regulation TNF IL16 21533451 479112 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL16 2471522 111755 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL16 2788284 116849 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL16 7986155 282329 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL17A 17384030 1715799 MMPs , IL-1 , and [TNF] are *regulated* by in periodontitis . Regulation TNF IL17A 18512248 1945203 The *effect* of on IL-8 and [TNF-alpha] mRNA expression in epithelial cell line Caco-2 was studied . Regulation TNF IL17A 19741298 2147227 We conclude that chronic production of [TNF-alpha] in the tumor microenvironment increases myeloid cell recruitment in an *dependent* manner that contributes to the tumor promoting action of this proinflammatory cytokine . Regulation TNF IL17A 20345974 2287657 Ingestion of faecal slurry resulted in a transient , early onset of proinflammatory interferon (IFN)-gamma , [tumour necrosis factor (TNF)-alpha] and *response* that was maximal at day 3 . Regulation TNF IL17A 21084465 2371766 Increased pulmonary [tumor necrosis factor] alpha , interleukin-6 (IL-6) , and *responses* compensate for decreased gamma interferon production in anti-IL-12 autovaccine treated , Mycobacterium bovis BCG vaccinated mice . Regulation TNF IL17C 21628458 2454650 [Tumor necrosis factor] a-mediated induction of in human keratinocytes is *controlled* by nuclear factor ?B . Regulation TNF IL18 10221659 609497 Taken together , these findings demonstrate that is *responsible* for the progression of endotoxin induced liver injury as well as down-regulation of endotoxin induced [TNF-alpha] production in P. acnes primed mice . Regulation TNF IL18 11520077 851912 however , IL-18 induced expression of ICAM-1 in monocytes was not inhibited by anti-IL-12 , anti-TNF-alpha , or anti-IFN-gamma Ab , suggesting the independence of the upregulating *effect* of on endogenous IL-12 , [TNF-alpha] , and IFN-gamma production . Regulation TNF IL18 11883701 919689 We examined the therapeutic *effect* of on the modulation of [TNF-alpha] gene expression in failing heart in a murine model of heart failure caused by viral myocarditis . Regulation TNF IL18 12535207 1049434 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL18 1598496 188887 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL18 17032165 1630714 The cumulative *effects* of define a novel role for this cytokine as a molecular survival switch that functions to both decrease cell death through inhibition of the mitochondrial apoptotic pathway and enhance [TNF] induction of prosurvival factors . Regulation TNF IL18 17523872 1746092 Here , we investigated the *role* of on nitric oxide ( NO ) and [tumor necrosis factor-alpha (TNF-alpha)] production by CD11b ( + ) adherent peritoneal cells , focusing on the involvement of endogenously produced IFN-gamma . Regulation TNF IL18 21533451 479113 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL18 2471522 111756 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL18 2788284 116850 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL18 7986155 282330 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL19 12535207 1049435 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL19 1598496 188888 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL19 21533451 479114 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL19 2471522 111757 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL19 2788284 116851 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL19 7986155 282331 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL1A 10201952 605707 These results suggest that the IL-1 induction of corneal LC migration is largely mediated by TNFR function , whereas [TNF-alpha] induction of LC migration is *independent* of activity . Regulation TNF IL1A 10573218 568796 Therefore the effect of a beta2-agonist , procaterol and theophylline on the release of ECA from a BEC line , BEAS-2B was evaluated in *response* to and [tumour necrosis factor-alpha (TNF-alpha)] . Regulation TNF IL1A 11028547 739578 SP-A inhibited the lipopolysaccharide (LPS) induced [TNFalpha] response of both interstitial and alveolar human Mphi , as well as the *response* in iMphi . Regulation TNF IL1A 12676771 1076912 Chemotactic chemokines can be released from lung fibroblasts in *response* to and [tumor necrosis factor (TNF)-alpha] . Regulation TNF IL1A 1280478 203155 Human arterial smooth muscle cells synthesize granulocyte colony stimulating factor in *response* to and [tumor necrosis factor-alpha] . Regulation TNF IL1A 15467353 1305766 This study suggests that sympathetic nerves have an inhibitory effect on in periapical lesions and a stimulatory *effect* on [TNF-alpha] in the intact rat pulp . Regulation TNF IL1A 15972960 1424324 Interestingly , blocking IL-17 suppressed synovial expression of both IL-1beta and tumor necrosis factor-alpha , whereas blocking did not *affect* [tumor necrosis factor-alpha] levels . Regulation TNF IL1A 16087381 1517217 Experimental data suggest that may be *involved* chiefly in joint destruction and [TNF] in joint inflammation . Regulation TNF IL1A 1774433 175459 These results suggest that [TNF] plays a major role in the pathogenesis of galactosamine/LPS hepatitis in mice and that *acts* synergistically with TNF in this hepatitis model . Regulation TNF IL1A 1779975 175868 We examined the *effect* of exogenous and TNF on [TNF] gene expression by Northern blot analysis . Regulation TNF IL1A 1942768 170696 We report that transformed TEC express low levels of [TNF alpha] in *response* to LPS or as a secreted product and as a cytotoxic membrane associated molecule displayed on the cell surface . Regulation TNF IL1A 19778597 2163670 Aqueous extract of Vitex trifolia leaves showed significant dose- and time dependent inhibitory activity on beta , IL-6 and iNOS mRNA synthesis , but slight *effect* on [tumor necrosis factor (TNF)-alpha] , all of which are involved in the inflammatory response . Regulation TNF IL1A 20078866 2218691 Inhibitions of IAPs , and TNFalpha might be a possible target for PC treatment since IAPs are the proteins that inhibited apoptosis ( favour proliferation ) and IL-1alpha and [TNFalpha] would *affect* all the transduction pathway involucrate in the activation of transcription factors related to survival or proliferation ( NF-kB , Elk-1 or ATF-2 ) . Regulation TNF IL1A 20646344 2292585 In the current study , we report the divergent effects of two biological based RA therapies which target [TNFalpha] function ( infliximab ) or *response* ( anakinra ) on the development of the NOS2 positive phenotype by PBDM in patients with refractory RA . Regulation TNF IL1A 20704555 2357002 The removal of , TNF-a and/or VEGF , a strong angiogenic inducer highly over expressed in AD brains , by means of specific antibody coated beads in RHA media *affects* RCEC release of IL-1ß , IL-6 and [TNF-a] . Regulation TNF IL1A 2147201 145427 Independent *regulation* of IFN-gamma and [tumor necrosis factor] by in human T helper cells . Regulation TNF IL1A 2201834 140500 Thus , the *effect* of on AML-CFU proliferation is not the result of direct activation of AML progenitors , but IL-1 stimulates the release of [TNF-alpha] by AML cells and endogenous TNF subsequently synergizes with IL-3 or GM-CSF . Regulation TNF IL1A 22693231 2638684 Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure , interleukin 6 (IL-6) , interleukin 10 (IL-10) , interleukin 12 (IL-12) , and [tumor necrosis factor a (TNF-a)] *responses* to Toll-like receptor (TLR) 3 and TLR4 stimulation . Regulation TNF IL1A 24363499 2881760 In addition , CM increased IL-10 levels and counteracted the stimulating *effects* of on the production of [tumor necrosis factor-a] , IL-6 , prostaglandin E2 , and NO measured as nitrite and the mRNA expression of these cytokines , CCL-2 , CCL-3 , CCL-4 , CCL-5 , CCL-8 , CCL-19 , CCL-20 , CXCL-1 , CXCL-2 , CXCL-3 , CXCL-5 , CXCL-8 , cyclooxygenase-2 , microsomal prostaglandin E synthase-1 , and inducible NO synthase . Regulation TNF IL1A 2496917 109701 The purpose of this study was to determine if recombinant murine interleukin 1 beta ( rMu-IL-1 beta ) alone or in combination with recombinant murine gamma-interferon ( rMu-IFN-gamma ) could activate murine macrophages to be tumoricidal against tumor necrosis factor (TNF)-insensitive target cells and to evaluate the possible *role* of in murine macrophage activation by recombinant murine [tumor necrosis factor] ( rMu-TNF ) plus rMu-IFN-gamma . Regulation TNF IL1A 2541208 110488 The data show that and beta and [TNF-alpha] and beta differentially *regulate* fibroblast functions , and that increases in catabolic functions like collagenase activity production are more than tenfold greater than increases in anabolic functions like collagen production . Regulation TNF IL1A 2784408 109021 It is unclear whether TNF alpha stimulates HSN to produce IL-1 , but the antibody data suggest that extracellular is not *responsible* for [TNF alpha] in vitro activity . Regulation TNF IL1A 3038998 76272 and PMA together had an additive *effect* on [TNF] binding . Regulation TNF IL1A 3045826 97123 We also demonstrated that the [IL-2/TNF] synergistic induction of LAK activity did not *involve* either or interferon-gamma . Regulation TNF IL1A 3264252 101496 The results suggest that early changes in serine/threonine protein kinase activity may be involved in *responses* of fibroblasts to and [TNF] . Regulation TNF IL1A 8325511 223342 Northern blot analysis reveals a single 1.7-kb mRNA species that is differentially regulated by lipopolysaccharide , phorbol myristate acetate , and [tumor necrosis factor] but is not *regulated* by human recombinant . Regulation TNF IL1A 8658528 364937 By reverse transcription-polymerase chain reaction we were able to show that the neutralizing antibody also partially prevented TBT induced in vivo IL-6 expression but no TBT induced TNF-alpha expression , suggesting a paracrine *effect* of on IL-6 production but not [TNF-alpha] expression and indicating that other inflammatory mediators are involved . Regulation TNF IL1A 8743284 377148 This study provides no arguments for the *involvement* of endogenous in [TNF alpha-] or IL-6 induced activation of the HPA axis . Regulation TNF IL1A 8757625 377751 The bidirectional effects of TNF-alpha on hematopoietic growth factor induced survival of hematopoietic progenitors were reflected in that TNF-alpha enhanced apoptosis of Lin- Sca-1+ cells when combined with SCF , whereas [TNF-alpha] synergistically suppressed apoptosis in *response* to . Regulation TNF IL1A 9089293 421819 Besides demonstration of this novel mechanism of IL-1 stimulated TNF-alpha expression , our data indicate an important *role* of in [TNF-alpha] production of cytotrophoblastic cells . Regulation TNF IL1A 9357863 462084 We investigated expression of 92-kDa gelatinase and TIMP-1 in *response* to lipopolysaccharide (LPS) and to the proinflammatory cytokines and [tumor necrosis factor (TNF)-alpha] . Regulation TNF IL1A 9488415 488730 Despite this defect , both mutant mouse strains had a rather normal proinflammatory cytokine response ( interleukin-12 [ IL-12 ] , IFN-gamma , IL-6 ) , with the exception of an impaired [tumor necrosis factor] alpha and *response* in IFN-gammaR ( -/- ) mice , demonstrating that only the latter two cytokines are dependent on IFN-gamma activation . Regulation TNF IL1A 9575340 502654 Central differentially *regulates* peripheral IL-6 and [TNF] synthesis . Regulation TNF IL1B 10532635 562349 To investigate the *role* of in regulation of [tumor necrosis factor-alpha (TNF-alpha)] and intercellular adhesion molecule-1 ( ICAM-1 ) during focal cerebral ischemia , the authors studied mutant mice deficient in the IL-1 converting enzyme (ICE) gene ( ICE knockout [ KO ] mice ) . Regulation TNF IL1B 11742863 887434 We report here that SMCs isolated from the neointima of injured rat aortas are characterized by increased expression of [TNF-alpha] in *response* to and gamma-interferon compared with medial SMCs . Regulation TNF IL1B 12626343 1112591 To test this hypothesis , recombinant human IL-10 was evaluated for its capacity to attenuate the release of neutrophil chemotactic activity and IL-8 from a human epithelial cell line in *response* to and [tumor necrosis factor-alpha] . Regulation TNF IL1B 12676771 1076914 Similarly , the release of the chemoattractants IL-8 , granulocyte colony stimulating factor , monocyte chemoattractant protein-1 , macrophage colony stimulating factor , and granulocyte/macrophage colony stimulating factor , from HFL-1 , were evaluated in *response* to and [TNF-alpha] . Regulation TNF IL1B 1530600 200040 However , PCR by using cDNA prepared from interleukin-1 beta (IL-1 beta) stimulated RPE cells revealed expression of the gene , suggesting in vivo production of [TNF-alpha] from RPE cells in *response* to . Regulation TNF IL1B 16499573 1528910 When infected HeLa cells were co-cultured with THP-1 cells , IL-6 and IL-8 secretion was sustained , expression followed a bell shaped curve and IL-10 , IL-12p70 and [TNF-alpha] synthesis was down *regulated* . Regulation TNF IL1B 16616208 1582983 In the present study , we examined the *effect* of on the expression of IL-1beta , IL-6 , IL-8 , IL-11 , [tumor necrosis factor-alpha (TNF-alpha)] , and their receptors in human chondrocytes . Regulation TNF IL1B 1698309 141439 and [TNF-alpha] *responses* of Mo from males ( 18-35 years ) with newly diagnosed ( n = 10 ) and long standing IDDM ( n = 10 ) and from age- and HLA-DR matched healthy males ( n = 10 ) were studied . Regulation TNF IL1B 17295604 1725900 The data are consistent with a *role* for [TNF-alpha] , and possibly for , in mediating increased bone resorption during estrogen deficiency in women . Regulation TNF IL1B 1732280 181436 In this study , we examined the *effect* of human recombinant on the expression of [TNF-alpha] by CH235-MG human malignant glioma cells . Regulation TNF IL1B 17369098 1748309 Maternal genomic variations influence both [tumor necrosis factor-alpha] and *response* to BV-related organisms ( anaerobic Gram negative bacteria and Gardnerella vaginalis in particular ) in the vagina and the risk of spontaneous preterm birth . Regulation TNF IL1B 1739130 182040 Both displayed a time- and dose dependent increase in steady-state levels of IL-8 mRNA in *response* to and [TNF-alpha] . Regulation TNF IL1B 17438450 1729272 [Tumor necrosis factor] alpha and *responses* to LPS partially recovered , whereas IL-8 and IL-10 responses recovered . Regulation TNF IL1B 18239058 1877025 Human pancreatic periacinar myofibroblasts expressed IL-32alpha in *response* to , [TNF-alpha] , and IFN-gamma . Regulation TNF IL1B 18276934 1911667 Excess decidual cell expressed matrix metalloproteinases ( MMPs ) 2 and 9 , in *response* to preeclampsia related and [tumor necrosis factor alpha (TNF)] , may inappropriately degrade these basement membrane proteins and impede EVT invasion . Regulation TNF IL1B 18515164 1934174 The present study was designed to evaluate the *effects* of on the expression of its corresponding receptor IL-1 RI , as well as on the closely related [TNFalpha] receptors TNF RI and TNF RII in airways using a mouse organ culture assay and intranasal inoculation model . Regulation TNF IL1B 19901996 2161752 We determined the *role* of signaling on tumor necrosis factor alpha induced ( TNF-alpha ) lung neutrophil influx as well as neutrophil chemoattractant macrophage inflammatory protein ( MIP-2 ) and KC and soluble [TNF-alpha receptor (TNFR)] levels utilizing wildtype ( WT ) , TNF receptor double knockout ( TNFR1/TNFR2 KO ) , and IL-1beta KO mice after oropharyngeal instillation with TNF-alpha . Regulation TNF IL1B 19940926 2167650 Importantly , Nestin-Cre and GFAP-Cre rank ( floxed ) deleter mice are resistant to lipopolysaccharide induced fever as well as fever in *response* to the key inflammatory cytokines and [TNFalpha] . Regulation TNF IL1B 2212667 142734 In the present study , we demonstrate that human peripheral blood PMN produce IL-1 beta in *response* to IL-1 alpha , , and [TNF-alpha] . Regulation TNF IL1B 2221137 142843 These data support the hypotheses that is responsible for a significant part of LPS fever and that [TNF] *acts* as an endogenous antipyretic to limit the magnitude of LPS fever in the rat . Regulation TNF IL1B 2547724 115636 In contrast to other cell types , eosinophils are unique in their differential *responses* to and [TNF] . Regulation TNF IL1B 8544101 338866 Pretreatment of GF cells with IL-1 beta resulted in the enhanced synthesis of [TNF-alpha] in *response* to additional . Regulation TNF IL1B 8663179 368394 Interleukin-8 (IL-8) , a potent neutrophil chemotactic peptide that elicits pleiotropic biological effects is secreted in large amounts by normal human osteoblastic and bone marrow osteoprogenitor stromal ( HBMS ) cells in *response* to and [tumor necrosis factor-alpha] . Regulation TNF IL1B 8840155 386692 The data provide evidence for an in vivo *role* for epidermal IL-1 alpha , and TNF-alpha transcription in the regulation of IL-1 beta and [TNF-alpha] polypeptide levels in the epidermis in response to this common contact allergen . Regulation TNF IL1B 8964827 366119 There also was a trend towards decreased expression of the alpha 6 subunit in *response* to interleukin-1 alpha , , and [tumor necrosis factor-alpha] . Regulation TNF IL1B 9025720 405837 Diminished GH receptor mRNA concentrations in *response* to and [TNF-alpha] indicate that low IGF-I levels during severe illness , despite high circulating GH levels , may at least partially be a consequence of suppression of hepatic GH receptor synthesis by IL-1 beta and TNF-alpha . Regulation TNF IL1B 9079634 420546 Role of NF-kappaB in [tumor necrosis factor-alpha] and *regulation* . Regulation TNF IL1B 9103454 423283 In contrast *affected* neither its own receptors nor the [TNF-R] . Regulation TNF IL1B 9357863 462090 Quantitative RT-PCR demonstrated that TIMP-1 mRNA levels remained unchanged in *response* to LPS or but decreased by 70 % in the presence of [TNF-alpha] . Regulation TNF IL1B 9609762 508760 Mesenchymal cells dose-dependently proliferated in *response* to , IL-6 , and [TNF-alpha] . Regulation TNF IL1B 9722689 529140 PGE2 , , and [TNF-alpha] *responses* in diabetics as modifiers of periodontal disease expression . Regulation TNF IL1R1 9135576 427822 The LPS induced release of cytokines was affected by previous immunoneutralization as compared with control experiments with normal immunoglobulin ( IgG ) : did not *affect* serum [TNF alpha] but decreased serum IL-6 , anti-TNF alpha decreased serum TNF alpha but not IL-6 , anti-IL-6 did not affect serum TNF alpha but hugely increased IL-6 and anti-IFN gamma decreased both serum TNF alpha and IL-6 . Regulation TNF IL1RN 7882594 298880 The immediate permeability was inhibited by H1-antihistamine but was not *affected* by [anti-TNF alpha] , by , or by depletion of neutrophils . Regulation TNF IL1RN 7882594 298882 The delayed permeability was completely inhibited by either depletion of neutrophils or by [anti-TNF alpha] and was not *affected* by or antihistamine . Regulation TNF IL1RN 8690044 372624 The bone resorbing activity of [tumor necrosis factor-alpha (TNF-alpha)] or lymphotoxin ( LT ) , tested alone or added to MM cell supernatants , was *affected* not at all by and only minimally by sIL-1R types I and II , suggesting that little or no endogenous IL-1 was produced by the rat cells in the assay under TNF-alpha or LT stimulation . Regulation TNF IL2 12165278 972797 The *effect* of on the production of [tumour necrosis factor-alpha (TNF)] and interleukin-6 (IL-6) by PBMCs isolated from patients with gastrointestinal cancer , multiple organ failure , and healthy controls was also studied . Regulation TNF IL2 12165278 972801 had no *effect* on IL-6 or [TNF] production by PBMCs isolated from any group in the presence or absence of bacterial lipopolysaccharide (LPS) . Regulation TNF IL2 12535207 1049436 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL2 1353987 192648 Anti-CD3 induced TNF-alpha production could be inhibited by blocking the IL-2R with a combination of anti-Tac and Mik beta 1 ( mAbs against the p55 and p75 chain of the IL-2R respectively ) thus indicating an essential *role* of in [TNF-alpha] induction . Regulation TNF IL2 1516257 196788 Peripheral blood mononuclear cells ( PBMC ) from untreated patients produced IL-1 beta , [tumour necrosis factor-alpha (TNF-alpha)] and IL-6 in *response* to mitogenic stimulation with phytohaemagglutinin ( PHA ) , only low levels of IL-1 beta , and TNF-alpha in response to OvAg , but higher amounts of IL-4 and interferon-gamma (IFN-gamma) in response to OvAg than control individuals . Regulation TNF IL2 1598496 188889 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL2 1700275 143303 RNA processing is a limiting step for murine [tumor necrosis factor] beta expression in *response* to . Regulation TNF IL2 1717551 166824 Low levels of TNF were produced in response to IL-7 at day 5 , as opposed to a 50-fold higher [TNF] production in *response* to . Regulation TNF IL2 17523134 1762097 This reduction was dose and time dependent , suggesting a regulatory *role* of in [TNF] secretion that might occur at the post-transcriptional level . Regulation TNF IL2 1906383 161699 *Effects* of granulocyte-macrophage colony stimulating factor ( GM-CSF ) , , interferon-gamma (IFN-gamma) , tumour necrosis factor-alpha (TNF-alpha) and IL-6 on the production of immunoreactive IL-1 and [TNF-alpha] by human monocytes . Regulation TNF IL2 1906383 161707 The *effects* of GM-CSF , , IFN-gamma , TNF-alpha and IL-6 on the production of IL-1 ( both secreted and cell associated ) and [TNF-alpha] by peripheral blood monocytes were studied . Regulation TNF IL2 1909711 166107 Francisella tularensis induced in vitro gamma interferon , [tumor necrosis factor] alpha , and *responses* appear within 2 weeks of tularemia vaccination in human beings . Regulation TNF IL2 2144468 140068 We examined cytokine production by IL-2 treated , nonmonocytic PBMC and found that a population of nonadherent low-density cells ( NLDC ) produced both IL-1 beta and [TNF alpha] in *response* to . Regulation TNF IL2 21533451 479115 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL2 2308780 129970 The [IL-2/TNF] driven generation of LAK activity *involves* the induction of high affinity receptors on LGL and occurs without promoting a significant proliferation , suggesting a functional activation rather than a proliferative expansion of LAK precursors . Regulation TNF IL2 2334896 132665 In vitro pretreatment of macrophages with IL-4 largely abolished their ability to synthesize [TNF] in *response* to or lipopolysaccharide . Regulation TNF IL2 2422147 58111 Priming *effect* of interferons and on endogenous production of [tumor necrosis factor] in mice . Regulation TNF IL2 2422147 58112 The *effects* of interferons ( IFNs ) and on endogenous production of [tumor necrosis factor (TNF)] were investigated in mice . Regulation TNF IL2 2445926 79883 The priming *effect* of endogenous biological response modifiers ( BRMs ) , interferons ( IFNs ) , and , and the triggering effect of BRMs of bacterial origin , OK-432 and Corynebacterium parvum , on endogenous production of the [tumor necrosis factor (TNF)] were investigated in mice . Regulation TNF IL2 2471522 111758 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL2 2550551 117587 *Regulation* of lymphocyte [tumor necrosis factor] receptors by . Regulation TNF IL2 2783642 106917 AM phi exhibited statistically greater ( p less than 0.05 ) [TNF] production in *response* to both and LPS as compared to PBM . Regulation TNF IL2 2788284 116852 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL2 7759599 307826 This was corroborated in experiments demonstrating that when Free cells were cultured with both IFN-alpha and IL-2 , a significant inhibition was observed for both the *dependent* secretion of [TNF-alpha] and proliferation . Regulation TNF IL2 7867077 296410 *Regulation* of [TNF-alpha] promoter activity by , IFN-gamma , GM-CSF , and IL-4 was examined in the U937 macrophage cell line and the MLA 144 T cell line . Regulation TNF IL2 7986155 282332 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL2 7994039 283061 These results indicate ( 1 ) that IL-2 and [TNF] receptors are related to each other on leukemic cells in B-CLL and ( 2 ) that the is *involved* in the regulation of other structures , ie , CSF receptors , thus pointing to another functional role of this receptor complex and the related cytokine in leukemic cells . Regulation TNF IL2 8064221 268850 Finally , [TNF-alpha] production in *response* to and sCD23 precedes IFN-gamma and IFN-gamma secretion is significantly inhibited by anti-TNF-alpha mAb , indicating that the sCD23 costimulatory signal for IFN-gamma production may be partially mediated by TNF-alpha release . Regulation TNF IL2 9659158 517172 Conversely , antibody to [TNF-alpha] reduced IEL proliferation in *response* to or IL-7 . Regulation TNF IL2 9679667 520857 Transgenic expression of cytokines in beta-cells of non-diabetes-prone mice and NOD mice has suggested pathogenic roles for IFN alpha , IFN gamma , and IL-10 in insulin dependent diabetes mellitus ( IDDM ) development , and protective *roles* for IL-4 , IL-6 and [TNF alpha] . Regulation TNF IL20 12535207 1049437 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL20 1598496 188890 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL20 21533451 479116 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL20 2471522 111759 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL20 2788284 116853 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL20 7986155 282333 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL21 12535207 1049438 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL21 1598496 188891 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL21 21533451 479117 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL21 2471522 111760 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL21 2788284 116854 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL21 7986155 282334 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL22 12535207 1049421 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL22 15039135 1272715 did not *affect* IL-10 inhibition of [tumor necrosis factor-alpha] in monocytes , which do not express IL-22R1 . Regulation TNF IL22 1598496 188874 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL22 21533451 479100 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL22 2471522 111743 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL22 2788284 116837 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL22 7986155 282317 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL23A 16830103 1586771 Finally , isolated Kupffer cells produced [TNFalpha] in *response* to , but not IL-12 , suggesting that IL-23 may be the relevant initiator of the hepatic inflammatory response to ischemia/reperfusion . Regulation TNF IL24 12535207 1049419 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL24 1598496 188872 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL24 21533451 479098 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL24 2471522 111741 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL24 2788284 116835 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL24 7986155 282315 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL25 12535207 1049420 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL25 1598496 188873 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL25 21533451 479099 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL25 2471522 111742 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL25 2788284 116836 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL25 7986155 282316 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL26 12535207 1049425 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL26 1598496 188878 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL26 21533451 479104 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL26 2471522 111747 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL26 2788284 116841 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL26 7986155 282321 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL27 12535207 1049426 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL27 1598496 188879 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL27 21533451 479105 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL27 2471522 111748 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL27 2788284 116842 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL27 7986155 282322 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL3 12535207 1049439 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL3 1598496 188892 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL3 21533451 479118 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL3 2471522 111761 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL3 2788284 116855 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL3 7986155 282335 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL31 12535207 1049427 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL31 1598496 188880 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL31 21533451 479106 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL31 2471522 111749 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL31 2788284 116843 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL31 7986155 282323 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL32 12535207 1049424 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL32 1598496 188877 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL32 21533451 479103 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL32 2471522 111746 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL32 2788284 116840 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL32 7986155 282320 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL33 12535207 1049423 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL33 1598496 188876 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL33 21533451 479102 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL33 21968692 2507441 *Effects* of on [TNF-a] and IL-6 productions were investigated . Regulation TNF IL33 2471522 111745 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL33 2788284 116839 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL33 7986155 282319 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL34 12535207 1049428 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL34 1598496 188881 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL34 21533451 479107 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL34 2471522 111750 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL34 2788284 116844 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL34 7986155 282324 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL37 12535207 1049422 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL37 1598496 188875 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL37 21533451 479101 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL37 2471522 111744 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL37 2788284 116838 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL37 7986155 282318 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL4 10211885 607706 had no *effect* on [TNFalpha] up-regulation of NF-kappaB , and a slight decrease was noted with IL-10 and IL-13 at the highest concentration used ( 5 ng/ml ) . Regulation TNF IL4 10227996 610527 We report here that the inhibitory *effects* of on the production of [TNF-alpha] or IL-12 by macrophages had both STAT6 dependent and -independent components , depending on the stimuli . Regulation TNF IL4 10736095 679355 So , the inhibitory *effect* of on either production of IFN-gamma , [TNF-alpha] and/or IL-12 or their receptors could be the mechanism underlying the lack of the hsp65 CTL generation in cells from MB . Regulation TNF IL4 10805227 691956 Dual *effect* of on resistance to systemic gram negative infection and production of [TNF-alpha] . Regulation TNF IL4 11000288 734470 In contrast , [TNF alpha] favoured expression of smaller tenascin-C transcripts , and equally *affected* the expression of large and small tenascin-C mRNAs . Regulation TNF IL4 11477201 841982 thus , to further clarify the differences of monocyte function and differentiation between neonates and adults , we investigated their CD14 ( + ) CD4 ( + ) and CD14 ( + ) CD16 ( + ) monocyte subpopulations , production of IL-1beta and [tumor necrosis factor-alpha] induced by lipopolysaccharide , and their CD14 and CD1a phenotypic changes in *response* to and granulocyte-macrophage colony stimulating factor . Regulation TNF IL4 11491045 845682 Inhibitory *effect* of on the production of IL-1 beta and [TNF-alpha] by gastric mononuclear cells of Helicobacter pylori infected patients . Regulation TNF IL4 11505428 847925 had more consistent suppressive *effect* on [TNF-alpha] production . Regulation TNF IL4 11891780 920516 Of note , we present evidence that [TNF-alpha] may be involved in regulating RANTES and MIP-1alpha , and that may be *involved* in regulating MCP-1 . Regulation TNF IL4 12160517 971792 This result correlates with the well defined inhibitory *effect* of on [tumour necrosis factor alpha (TNFalpha)] production . Regulation TNF IL4 12535207 1049440 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL4 12569762 581594 Moreover , it was also found that the suppressive *effect* of on the expression of PBMCs [TNF-alpha] and IL-1 alpha mRNA in the patients with endotoxinemia and HBeAg was significantly decreased in acute phase . Regulation TNF IL4 12569762 581595 The inhibitory *effect* of on the expression of PBMCs [TNF-alpha] and IL-1 alpha mRNA is markedly decreased in acute phase as compared with that in recovery phase and this declined response may be related to endotoxinemia and viremia . Regulation TNF IL4 12860673 1111557 The *effects* of on bacterial replication and on [tumor necrosis factor (TNF)] production in monocytes were apparently not related . Regulation TNF IL4 14638848 1176706 In this paper , we investigated the regulatory *role* of in [TNF-alpha] production in mast cells . Regulation TNF IL4 15553672 1338691 Two out of 6 pts who experienced stable disease after the treatment had high IFN-gamma and [TNF-alpha] responses and no TGF-beta1 or *response* . Regulation TNF IL4 1559582 184602 The *effects* of recombinant human on the production of interleukin-1 (IL-1) and [tumour necrosis factor-alpha (TNF alpha)] by human alveolar macrophages ( AM ) and autologous peripheral blood monocytes ( PBM ) in response to lipopolysaccharide (LPS) were examined . Regulation TNF IL4 1571090 187166 differentially *regulates* [tumor necrosis factor-alpha] gene expression by human T lymphocytes and monocytes . Regulation TNF IL4 1598496 188893 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL4 1651157 163042 had no *effect* on the growth-stimulatory activity of [TNF] on normal human foreskin fibroblasts . Regulation TNF IL4 1695647 137135 *regulates* endothelial cell activation by IL-1 , [tumor necrosis factor] , or IFN-gamma . Regulation TNF IL4 17617590 1769630 and IL-13 negatively *regulate* [TNF-alpha-] and IFN-gamma induced beta-defensin expression through STAT-6 , suppressor of cytokine signaling (SOCS)-1 , and SOCS-3 . Regulation TNF IL4 2026443 157414 To investigate whether opposing activities of IL-4 reflect a difference in the target cell studied , due either to cell maturation or the site from which the cells were isolated , we examined the *effect* of on human peritoneal macrophage production of IL-1 beta , [TNF-alpha] and prostaglandin E2 ( PGE2 ) . Regulation TNF IL4 20406299 2300595 We investigated whether the early induction of SOCS1 by was *responsible* for the suppression of LPS induced [tumour necrosis factor (TNF)-alpha] production by IL-4 . Regulation TNF IL4 2119829 141846 To elucidate which cytokines produced by monocytes are controlled by IL-4 , we tested the *effect* of on the secretion of IL-1 alpha , IL-1 beta , [TNF alpha] , and IL-6 induced by LPS or IFN gamma . Regulation TNF IL4 21533451 479119 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL4 2334896 132666 Overall , these results demonstrate that IL-2 and can act antagonistically to *regulate* [TNF] production by macrophages . Regulation TNF IL4 24056170 2843138 Moreover , serum level decreased significantly after treatment with 25 mg/kg and 125 mg/kg ATR , but ATR did not *affect* the expression of interleukin-2 , interferon-? , and [tumor necrosis factor-a] . Regulation TNF IL4 2471522 111762 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL4 2785566 111565 The *effects* of on IL-1 and [TNF] gene expression in human peripheral monocytes ( PBM ) were examined . Regulation TNF IL4 2788284 116856 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL4 7540642 310124 Seven-day cultured monocytes/macrophages showed ( 1 ) diminished [TNF-alpha] production in *response* to IL-10 but not ( 2 ) , diminished IL-1 beta production in response to both IL-4 and IL-10 , and compared with fresh monocytes ( 3 ) , diminished CD14 expression in response to IL-4 , and ( 4 ) a lesser increase in CD23 expression in response to IL-4 . Regulation TNF IL4 7689258 225737 Unexpectedly , rapamycin actually synergized with IL-4 in both the upregulation of CD23 expression and the down-regulation of the type II ( p75 ) TNF receptor , while in the same B cell line , rapamycin simultaneously inhibited the *dependent* production of [TNF alpha] and beta . Regulation TNF IL4 7790026 313167 Because IL-10 and differentially *regulate* [TNF-alpha] and IL-1ra production by synovial fluid mononuclear cells , selective use of either IL-10 or IL-4 in the treatment of chronic inflammatory conditions will depend on whether TNF-alpha or IL-1 , respectively , is established as primarily responsible for the maintenance of the chronic inflammatory condition . Regulation TNF IL4 7798548 281099 The *effects* of on the release of IL-1 , [tumor necrosis factor-alpha] , and IL-6 by monocytes and alveolar macrophages were compared in 19 patients with asthma and 18 control subjects . Regulation TNF IL4 7867077 296411 *Regulation* of [TNF-alpha] promoter activity by IL-2 , IFN-gamma , GM-CSF , and was examined in the U937 macrophage cell line and the MLA 144 T cell line . Regulation TNF IL4 7957562 278063 We , therefore , investigated the *effects* of IL-10 and on the cell surface expression and release of [TNF-R] by human monocytes to determine whether these cytokines also indirectly modulated the biological activity of TNF-alpha . Regulation TNF IL4 7986155 282336 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL4 8218932 231780 In this study we have investigated the *effects* of on the expression of both p55 and p75 [TNF receptors (TNF-R)] by flow cytometry and radioligand binding analyses and demonstrate that IL-4 downregulates both p55 and p75 TNF-R on HeLa and Jijoye cell lines in a dose dependent manner . Regulation TNF IL4 8289467 247697 We studied the *effects* of on tumour necrosis factor (TNF) induced and spontaneous proliferation ( 3H-TdR incorporation ) and spontaneous release of [TNF] and interleukin-6 (IL-6) by purified B-cell chronic lymphocytic leukaemia ( CLL ) cells in vitro . Regulation TNF IL4 8484092 218921 The *effects* of recombinant human and the glucocorticoid , dexamethasone , on [tumor necrosis factor alpha (TNF alpha)] and interleukin-1 beta (IL-1 beta) levels in cultures of rheumatoid and osteoarthritic synovial tissue were studied . Regulation TNF IL4 8660851 371771 The inhibitory *effect* of and IL-13 on the release of [TNF alpha] was partially reversed by neutralizing anti-IL10 antibody , and the inhibition of IL-6 release was completely reversed by the antibody . Regulation TNF IL4 8675208 369798 Thus IFN-gamma and may differentially *affect* the post-transcriptional control of [TNF-alpha] gene expression . Regulation TNF IL4 8704096 371126 Our data demonstrate that IL-1 alpha and [TNF-alpha] release by AMs is down *regulated* by , IL-10 , and TGF-beta . Regulation TNF IL4 8871669 389621 *Regulation* of surface and soluble [TNF] receptor expression on human monocytes and synovial fluid macrophages by and IL-10 . Regulation TNF IL4 8871669 389631 Addition of an Ab to IL-10 suggested that the stimulatory effects of LPS on p75 [TNF] receptor expression were due , at least in part , to LPS stimulation of IL-10 production and that *acted* , in part , by decreasing IL-10 production . Regulation TNF IL4 9918806 559199 Because various members of the mitogen activated protein kinases and their upstream kinases have been shown to directly or indirectly activate a number of transcription factors including AP-1 and NFkappaB , we examined the *effects* of on [TNF-alpha] activation of the MAPKs . Regulation TNF IL5 12535207 1049441 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL5 1598496 188894 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL5 21533451 479120 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL5 2471522 111763 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL5 2788284 116857 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL5 7986155 282337 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL6 10029203 591548 Females exhibited significantly higher corticosterone , [tumor necrosis factor-alpha] , and *responses* than males . Regulation TNF IL6 10210775 607657 The survival activity of [TNF-alpha] is not *affected* by or anti-gp130 monoclonal antibodies ( mAbs ) . Regulation TNF IL6 10616907 575888 We report that [TNF] induces DNA replication in growth arrested LE6 cells and that its effect *involves* the activation of NFkappaB and STAT3 and an increase in c-myc and mRNAs . Regulation TNF IL6 10810212 692745 We studied the effects of pretreatment with either ibuprofen ( 15 mg/kg ) , diethylcarbamazine ( DEC , 15 mg/kg ) , or vehicle , on the hemodynamic , hematologic , and serum [tumor necrosis factor-alpha (TNF-alpha)] and *responses* to a bolus Escherichia coli endotoxin infusion ( 2 mg/kg ) in 21 pentobarbital anesthetized dogs ( n = 7 each group ) . Regulation TNF IL6 10878380 708973 The acute-phase response ( APR ) is regulated by [TNF-alpha] , IL-1beta , and *acting* alone , in combination , or in concert with hormones . Regulation TNF IL6 11576469 865154 Hypoxic upregulation of [TNF] receptor type 2 expression *involves* and is independent of HIF-1 or HIF-2 . Regulation TNF IL6 11934972 927926 This suggests that [TNF-alpha] *controls* production . Regulation TNF IL6 12073205 956724 Blood samples for cytokine levels , [tumor necrosis factor (TNF)-alpha] , and *response* to CPB were collected after induction of anesthesia and at the end of CPB before protamine administration . Regulation TNF IL6 12096891 961157 The present study tested whether prior exposure to inescapable tailshock ( IS ) alters the interleukin (IL)-1beta , [tumor necrosis factor (TNF)-alpha] , or *response* to an injection of bacterial endotoxin ( lipopolysaccharide ; Regulation TNF IL6 12406900 1054812 In contrast , the [TNF-alpha] response to zymosan or Staphylococcus aureus as well as the and IL-8 *responses* to endotoxin were unaffected by ubiquitin . Regulation TNF IL6 12438335 1016588 In vitro experiments demonstrated a statistically significant , but modest , inhibitory *effect* of on [TNF-alpha] production by RAW cells stimulated with E. faecalis . Regulation TNF IL6 12524413 1047915 MMP2 secretion by PSCs was significantly increased by TGF-beta1 and , but was not *affected* by [TNF-alpha] . Regulation TNF IL6 12535207 1049442 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL6 1328056 197734 The *effect* of on [TNF] receptors was observed after 4 h and was reversible . Regulation TNF IL6 15290727 1278561 In vitro [tumor necrosis factor-alpha (TNF-alpha)] , interferon-gamma (IFN-gamma) , and *responses* were detected during reactions to most antigens tested , while IL-4 responses were absent . Regulation TNF IL6 15325406 1287145 The second objective was to assess effects of human recombinant IL-10 on and [tumour necrosis factor-alpha (TNF-alpha)] *responses* of human leukocytes to staphylococcal toxins implicated in SIDS . Regulation TNF IL6 1598496 188895 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL6 1612734 191095 Pretreatment with corticosterone and RU 486 ( +Cort/+RU 486/+LPS ) significantly ( P less than 0.001 ) reversed the mortality observed with RU 486 pretreatment alone ( -Cort/+RU 486/+LPS ) , with 70 % of the animals surviving at 72 h , and significantly attenuated the peak plasma [tumor necrosis factor] and *responses* to LPS , compared with those in the animals treated with vehicle alone . Regulation TNF IL6 1653625 164664 We have studied the *effect* of on the binding of [tumor necrosis factor (TNF)] to various cell lines . Regulation TNF IL6 16869254 1593033 Oxygen dependent killing was *controlled* mostly by during the pre-operative period , and by this plus [TNF-alpha] 24 hours after surgery . Regulation TNF IL6 1906383 161700 *Effects* of granulocyte-macrophage colony stimulating factor ( GM-CSF ) , IL-2 , interferon-gamma (IFN-gamma) , tumour necrosis factor-alpha (TNF-alpha) and on the production of immunoreactive IL-1 and [TNF-alpha] by human monocytes . Regulation TNF IL6 1906383 161708 The *effects* of GM-CSF , IL-2 , IFN-gamma , TNF-alpha and on the production of IL-1 ( both secreted and cell associated ) and [TNF-alpha] by peripheral blood monocytes were studied . Regulation TNF IL6 19380468 2094698 Cellular [tumor necrosis factor] , gamma interferon , and *responses* as correlates of immunity and risk of clinical Plasmodium falciparum malaria in children from Papua New Guinea . Regulation TNF IL6 19666104 2182972 Conversely , following TLR 9 stimulation there was a decrease in IL-1beta , , GM-CSF , and [TNFalpha] *responses* in monocyte cell cultures from children with ASD compared with controls ( p < 0.05 ) . Regulation TNF IL6 20029520 2175602 This aims of this study were to investigate the effects of carbohydrate availability during endurance training on the plasma , IL-8 , and [tumor necrosis factor (TNF)-alpha] *response* to a subsequent acute bout of high-intensity interval exercise . Regulation TNF IL6 21352507 2426444 In conclusion , *affects* exercise induced glycogen use , AMPK signalling and [TNF-a] mRNA responses in mouse skeletal muscle . Regulation TNF IL6 21533451 479121 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL6 22693231 2638685 Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß) , , interleukin 10 (IL-10) , interleukin 12 (IL-12) , and [tumor necrosis factor a (TNF-a)] *responses* to Toll-like receptor (TLR) 3 and TLR4 stimulation . Regulation TNF IL6 22714139 2670057 Childhood abuse history moderated levels but not [TNF-a] and CRP *responses* to daily stressors . Regulation TNF IL6 24138989 2882715 Furthermore , from the optimized IRN , we confirmed 45 interactions between proteins in biological experiments and identified 37 new regulatory interactions and 8 false positive interactions , including the following interactions : IL1ß regulates TLR3 , TLR3 *regulates* IFN-ß and [TNF] regulates . Regulation TNF IL6 2471522 111764 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL6 2788284 116858 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL6 7492273 335539 To test the hypothesis that pretreatment with liposomes enriched with the omega 3 fatty acid docosahexaenoic acid ( 22 : 6 omega 3 ) will alter the Kupffer 's cell and systemic cytokine ( [tumor necrosis factor] and ) *response* to endotoxin challenge , and to demonstrate alterations in Kupffer 's cell phospholipid fatty acid composition after in vivo liposome treatment . Regulation TNF IL6 7868900 296529 Moreover , [IFN-gamma/TNF] production was negatively *regulated* by . Regulation TNF IL6 7890366 299352 The data obtained with anti-IL-6 antibody indicate that endogenous is *involved* in regulating the levels of [TNF] and IFN-gamma in serum . Regulation TNF IL6 7927780 273970 The *effect* of anti-IL-6 monoclonal antibodies and recombinant on lethality and [TNF-alpha] production was investigated . Regulation TNF IL6 7927780 273972 Collectively , our data are compatible with the hypothesis that is *involved* in negative feedback regulation of plasma [TNF-alpha] levels in experimental GBS sepsis . Regulation TNF IL6 7929820 274669 We present data to show that the expression of [TNF alpha] is *regulated* by the transcription factor C/EBP beta ( ) . Regulation TNF IL6 7978630 281268 In contrast , compared with effects of endotoxin given without pretreatment , use of antiserum was associated with significantly ( P < 0.05 ) higher respiratory rate , maximal plasma activity , and total [TNF] *response* ( as determined by areas under curves of plasma TNF vs time ) . Regulation TNF IL6 7986155 282338 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL6 8284058 240641 Serum endotoxin , [tumor necrosis factor] , and *response* to total hip arthroplasty . Regulation TNF IL6 8537402 338620 Transcriptional *roles* of nuclear factor kappa B and nuclear in the [tumor necrosis factor] alpha dependent induction of cyclooxygenase-2 in MC3T3-E1 cells . Regulation TNF IL6 9050747 406034 Furthermore , this upregulatory *effect* of was mainly attributable to an increase in the number of plasma membrane [TNF-alpha] specific receptors , with little change in their affinity . Regulation TNF IL6 9087647 421678 The data indicate that IL-1 and [TNF] *act* locally at the site of inflammation and that locally induced is the important systemic mediator of the response . Regulation TNF IL6 9135576 427823 The LPS induced release of cytokines was affected by previous immunoneutralization as compared with control experiments with normal immunoglobulin ( IgG ) : anti-IL-1R did not affect serum TNF alpha but decreased serum IL-6 , anti-TNF alpha decreased serum TNF alpha but not IL-6 , did not *affect* serum [TNF alpha] but hugely increased IL-6 and anti-IFN gamma decreased both serum TNF alpha and IL-6 . Regulation TNF IL6 9195128 438202 Co-administration of soluble IL-6 receptor ( sIL-6R ) did not enhance the *effect* of on brain [TNF] , so this refractoriness can not be attributed to a lack of IL-6 receptors . Regulation TNF IL6 9555981 499232 These mice carry the loci If-1h ( high ) or If-1l ( low ) , respectively , that are responsible for up to tenfold differences in the interferon (IFN)-alpha , IFN-beta , , and [tumor necrosis factor-alpha (TNF-alpha)] *response* to NDV but not to Sendai virus . Regulation TNF IL7 12535207 1049443 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL7 1598496 188896 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL7 17045026 1635676 To investigate the *effect* of and interleukin-15 on the production of Th1 cytokines interferon-gamma (IFN-gamma) , [tumor necrosis factor-alpha (TNF-alpha)] and Th2 cytokines interleukin-4 (IL-4) , IL-10 by peripheral blood mononuclear cells ( PBMC ) from patients with tuberculosis . Regulation TNF IL7 1717551 166825 Low levels of [TNF] were produced in *response* to at day 5 , as opposed to a 50-fold higher TNF production in response to IL-2 . Regulation TNF IL7 21533451 479122 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL7 2471522 111765 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL7 2788284 116859 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL7 7986155 282339 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL7 9659158 517173 Conversely , antibody to [TNF-alpha] reduced IEL proliferation in *response* to IL-2 or . Regulation TNF IL8 11359438 816232 The inhibition of [TNF-alpha] , IL-6 and *response* was a dose dependent . Regulation TNF IL8 12406900 1054813 In contrast , the [TNF-alpha] response to zymosan or Staphylococcus aureus as well as the interleukin-6 (IL-6) and *responses* to endotoxin were unaffected by ubiquitin . Regulation TNF IL8 12535207 1049444 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL8 12538454 1049725 Repeated administrations of interleukin (IL)-12 are associated with persistently elevated plasma levels of IL-10 and declining IFN-gamma , [tumor necrosis factor-alpha] , IL-6 , and *responses* . Regulation TNF IL8 14720196 1197746 [TNF-alpha] was particularly related with angiogenesis and cartilage destruction and was *involved* in the acute stage of inflammation . Regulation TNF IL8 15513871 1328333 Human neutrophil chemotaxis and transmigration were determined in vitro in *response* to and/or [TNF-alpha] . Regulation TNF IL8 1598496 188897 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL8 16429233 1534088 Cellular activity of is mediated by the receptor CXCR2 , and transcription of IL8 is *controlled* by the cytokine tumour necrosis factor ( [TNFalpha] ) . Regulation TNF IL8 18544909 1923599 In conclusion , production was predominantly induced in THP-1 cells following allergen stimulation , and MAPK pathways and [TNF-alpha] were *involved* in the IL-8 production induced by DNCB and NiSO ( 4 ) . Regulation TNF IL8 19039059 1998764 The cell-wall preparation induced dose dependent IL-1beta , [TNF-alpha] , IL-6 , and *responses* in macrophages . Regulation TNF IL8 21533451 479123 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL8 2471522 111766 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL8 2788284 116860 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL8 7756650 307521 had no *effect* on IL-6R and TNF-alpha R , or on [TNF-alpha] and IL-6 production in these cells . Regulation TNF IL8 7986155 282340 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF IL8 9427069 472689 is *involved* in homologous [TNF alpha-] , but not in IL-1 beta induced neutrophil infiltration in rabbits . Regulation TNF IL9 11937570 928255 The suppressive *effect* of on the respiratory burst and [TNF-alpha] production in LPS stimulated monocytes was significantly inhibited by anti-TGF-beta1 , but not by anti-IL-10Rbeta mAb . Regulation TNF IL9 12535207 1049445 Although interleukin-12 is considered to act primarily on lymphocytes , provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha , we hypothesized that might also *affect* [tumor necrosis factor] alpha secretion from skin cells . Regulation TNF IL9 1598496 188898 Production of interleukin 8 by cultured synovial cells in *response* to 1 and [tumor necrosis factor] . Regulation TNF IL9 21533451 479124 *Involvement* of in the differentiation inducing activity of [tumor necrosis factor-alpha] on a murine myeloid leukemia ( WEHI-3B JCS ) . Regulation TNF IL9 2471522 111767 Production of monocyte chemotactic and activating factor ( MCAF ) by human dermal fibroblasts in *response* to 1 or [tumor necrosis factor] . Regulation TNF IL9 2788284 116861 Fibroblast interleukin 1 beta : synergistic stimulation by recombinant 1 and [tumor necrosis factor] and posttranscriptional *regulation* . Regulation TNF IL9 7986155 282341 [Tumor necrosis factor] and *regulation* by lipopolysaccharide pretreatment . Regulation TNF INS 10545284 564477 In conclusion , data presented suggest that might *regulate* superoxide generation and [TNF-alpha] release by leukocytes upon exposure to LPS in vivo . Regulation TNF INS 11443108 850418 To determine the signaling pathway involved in this [TNF-alpha] *response* to , we pretreated the cells with three distinct protein kinase inhibitors : wortmannin , PD98059 , and SB203580 . Regulation TNF INS 11443108 850420 These observations indicate that insulin stimulates TNF-alpha production in macrophages by regulating the expression of TNF-alpha mRNA and that the extracellular signal regulated kinase signaling pathway may have a critical role in stimulating the production of [TNF-alpha] in *response* to in macrophages . Regulation TNF INS 14532168 1185894 Therefore , we studied the *effect* of on IL-6 and [TNF-alpha] gene expression in human skeletal muscle and adipose tissue . Regulation TNF INS 15161606 1288208 We tested the hypothesis that acidosis or [TNF-alpha] , a cytokine whose production increases in acidosis , *regulates* proteolysis by inhibiting signaling through phosphoinositide 3-kinase (PI3K) . Regulation TNF INS 17158207 1694200 [TNFalpha] increased serine/threonine phosphatase activity of protein phosphatase 1 (PP1) in *response* to C6 , but not , suggesting a ceramide-specific effect . Regulation TNF INS 19208910 2061485 These cells produced interferon-gamma and [tumor necrosis factor-alpha] in *response* to peptide and were cytotoxic to insulin peptide coated targets . Regulation TNF INS 20699433 2335487 did not *affect* [TNF-a] , MCP-1 , IL-6 , LBP , resistin , and HMG-B1 increases induced by the LPS . Regulation TNF INS 2703526 108881 Thus , [TNF] stimulation of hepatic lipogenesis is *independent* of changes in . Regulation TNF INS 8334230 223743 The *effect* of epidermal growth factor (EGF) , basic fibroblast growth factor (bFGF) and on the cytostatic activity of [tumour necrosis factor-alpha (TNF-alpha)] was studied on the breast cancer cell line , T47D . Regulation TNF INTS1 18419534 1899724 Release of interferon-gamma (IFN-gamma) but not of [tumor necrosis factor-alpha] or interleukin-6 was *dependent* ; Regulation TNF IRAK1 12620219 1066174 Furthermore , recent data imply a *role* for in [tumor necrosis factor receptor (TNFR)] superfamily induced signaling pathways as well . Regulation TNF IRAK4 17157666 1661742 *plays* an important role in the production of type I IFN , as well as [TNF-alpha] , induced by all TLRs , including TLR3 . Regulation TNF IRF5 18332133 1904718 In addition , *regulates* [TNFalpha] but not type I interferon gene transcription in Newcastle disease virus infected peritoneal macrophages . Regulation TNF IRF5 20237317 2265973 In this study , we define the *role* for in secretion of [tumor necrosis factor (TNF)] by human dendritic cells (DCs) . Regulation TNF IRF5 20237317 2265977 We demonstrate that DCs but not macrophages have high levels of IRF5 protein , and that is *responsible* for the late-phase expression of [TNF] , which is absent in macrophages . Regulation TNF ISL1 19169644 2061131 The *effects* of on LPS induced NO and [TNF-alpha] production were reversed by the HO-1 inhibitor , tin protoporphyrin . Regulation TNF ISL2 19169644 2061130 The *effects* of on LPS induced NO and [TNF-alpha] production were reversed by the HO-1 inhibitor , tin protoporphyrin . Regulation TNF ITGA5 9565575 500928 Our results suggest that [TNF-alpha] may *regulate* macrophage differentiation and critical matrix degrading activities of myeloid progenitor cells in an autocrine manner by augmenting surface levels of the , thus promoting interactions with the extracellular matrix , a key event for maturation and migration of these cells during inflammation . Regulation TNF ITGAV 10992470 732919 The monocyte was *involved* in [TNF] synthesis since peptides containing RGD sequences and blocking antibodies against alpha(v)beta(3) integrin inhibited TNF transcripts induced by C. burnetii . Regulation TNF ITGAX 19909342 2247811 Thus , these results demonstrated that neutrophils , F4/80 ( + ) macrophages and Gr-1 ( dull+ ) ( + ) macrophage-like cells *played* an important role in the production of [TNF-alpha] in lungs at an early stage of infection with S. pneumoniae . Regulation TNF ITGB1 9565575 500929 Our results suggest that [TNF-alpha] may *regulate* macrophage differentiation and critical matrix degrading activities of myeloid progenitor cells in an autocrine manner by augmenting surface levels of the , thus promoting interactions with the extracellular matrix , a key event for maturation and migration of these cells during inflammation . Regulation TNF ITGB2 1399006 199411 These results suggest that may *play* an important role in the secretion of [TNF-alpha] and IL-1 beta by TSST-1 stimulated human monocytes , likely by promoting cell-cell adhesion between monocytes and lymphocytes . Regulation TNF ITGB3 10992470 732920 The monocyte was *involved* in [TNF] synthesis since peptides containing RGD sequences and blocking antibodies against alpha(v)beta(3) integrin inhibited TNF transcripts induced by C. burnetii . Regulation TNF JAG1 16081844 1442855 IFN-gamma and [TNF-alpha] *responses* to inactivated DEN were detected in up to 0.54 and 1.17 % of total circulating CD4+ T cells , respectively . Regulation TNF JAK1 17121792 1686277 However , inhibition of had little *effect* on cmvIL-10 mediated suppression of [tumor necrosis factor alpha (TNF-alpha)] production . Regulation TNF JAK1 22941906 2701708 The purpose of this study was to examine the *effects* of both inhibitors on inflammatory and [tumor necrosis factor (TNF)] responses in human macrophages . Regulation TNF JAK2 22941906 2701709 The purpose of this study was to examine the *effects* of both inhibitors on inflammatory and [tumor necrosis factor (TNF)] responses in human macrophages . Regulation TNF JAK3 22941906 2701710 The purpose of this study was to examine the *effects* of both inhibitors on inflammatory and [tumor necrosis factor (TNF)] responses in human macrophages . Regulation TNF JUN 10754326 682614 [TNF-alpha] gene expression in macrophages : regulation by NF-kappa B is *independent* of or C/EBP beta . Regulation TNF JUN 12874341 1115081 Activation of NF-kappa B and by P. aeruginosa GLP may be *involved* not only in [TNF-alpha] induction but also in many of the inflammatory responses triggered in the course of infection with P. aeruginosa . Regulation TNF JUN 12905745 1119129 To study the *effect* of nuclear on [tumor necrosis factor alpha (TNF-alpha)] or minimal modified low density lipoprotein ( mmLDL ) -induced expression of plasminogen activator inhibitor-1 ( PAI-1 ) in human vascular endothelial cells . Regulation TNF JUN 14736953 1199596 We investigated the *role* of NF-kappa B and in [tumour necrosis factor alpha (TNF-alpha)] induced monocyte chemoattractant protein 1 ( MCP-1 ) production in cultured human glomerular endothelial cells ( HGEC ) . Regulation TNF JUN 15313439 1285537 In view of the potential *role* of in the induction of [TNF-alpha] , we next examined the inhibitory effects of arctigenin on the expression of TNF-alpha . Regulation TNF JUN 15976518 1424459 DNA binding assays revealed that ethanol induced [TNF] up regulation was *dependent* . Regulation TNF JUN 16881863 1594531 Here , we report that activation of during dsRNA treatment or respiratory syncytial viral ( RSV ) infection negatively *regulates* the induction of [TNF-alpha] in human epithelial cells . Regulation TNF JUN 18302884 1873515 To study the *role* of in the up-regulation expression of [tumor necrosis factor-alpha (TNF-alpha)] and transforming growth factor-beta1 ( TGF-beta(1) ) in silica stimulated macrophage cells ( RAW264.7 ) . Regulation TNF JUN 19043087 2035344 The aim of this study was to investigate the *role* of signalling in cardiomyocyte [TNF-alpha] expression during lipopolysaccharide (LPS) stimulation and myocardial function in endotoxaemic mice . Regulation TNF JUN 20237583 2223929 Conversely , activation of negatively *regulates* [TNF-alpha] production through inhibition of ERK1/2 and p38 MAPK activity . Regulation TNF JUN 20663042 2298145 These results indicated that the downregulation of [TNF-alpha] by S. tenuifolia water extract may have *involved* the inhibition of both IkappaBalpha degradation and activation of and ATF-2 involving suppression of JNK/SAPK . Regulation TNF JUN 20716917 2181797 [Tumor necrosis factor-alpha] and apoptosis signal regulating kinase 1 *control* reactive oxygen species release , mitochondrial autophagy , and N-terminal kinase/p38 phosphorylation during necrotizing enterocolitis . Regulation TNF JUN 21849907 2496023 Its suppressive effect on [TNF-a] , I-309 , and IP-10 may , at least in part , *involve* the down-regulation of LPS induced expression . Regulation TNF JUN 7635431 317122 Using primary cultures of rat Kupffer cells the *role* of NF-kappa B and in the expression of the [tumor necrosis factor-alpha (TNF-alpha)] gene by lipopolysaccharide (LPS) was investigated . Regulation TNF JUN 8552071 347104 [Tumor necrosis factor] alpha gene regulation in activated T cells *involves* and NFATp . Regulation TNF JUN 8816436 383615 Cell-type-specific *regulation* of the human [tumor necrosis factor] alpha gene in B cells and T cells by NFATp and . Regulation TNF JUN 9933633 589483 Here we show that extracellular signal regulated kinase ( ERK ) , , and p38-mitogen activated protein kinase (MAPK) pathways *control* the transcription and synthesis of [TNF-alpha] in A3.01 T cells that produce the cytokine upon T cell activation by costimulation with 12-O-tetradecanoylphorbol-13-acetate ( TPA ) and ionomycin . Regulation TNF KHSRP 9551933 499118 We have examined the *roles* of p55 and in mediating and modulating the activity of [TNF] in vivo by generating and examining mice genetically deficient in these receptors . Regulation TNF KHSRP 9551933 499123 In summary , these data help clarify the biologic *roles* of p55 and in mediating and modulating the biologic activity of [TNF] and provide genetic evidence for an antagonistic role of p75 in vivo . Regulation TNF KITLG 8943730 400160 The *effect* of on histamine and [tumour necrosis factor-alpha (TNF-alpha)] release from rat peritoneal mast cells ( PMC ) was determined and the intracellular pathways involved in the potentiation of histamine secretion were investigated . Regulation TNF KLRC1 18096998 1847463 TNF-alpha produced by Ag-specific CD8+ T cells appears primarily responsible for this immunopathology , and we have examined the negative *regulation* of CD8+ [TNF] production by engagement with its receptor , Qa-1b . Regulation TNF KLRD1 11069065 747682 By the use of the MEK inhibitor PD098059 we demonstrate that the MAPK pathway participates in the *dependent* [TNF-alpha] production and cytotoxicity . Regulation TNF KLRD1 18096998 1847464 TNF-alpha produced by Ag-specific CD8+ T cells appears primarily responsible for this immunopathology , and we have examined the negative *regulation* of CD8+ [TNF] production by engagement with its receptor , Qa-1b . Regulation TNF KRT10 12813371 1103126 The purpose of this study was to examine the *effect* of on LPS induced gastric fluid accumulation , and gastric [tumor necrosis factor (TNF)-alpha] , inducible nitric oxide synthase (iNOS) , and cyclo-oxygenase (COX)-2 expression , as well as serum TNF-alpha protein levels over time . Regulation TNF KSR1 11751383 889873 Our laboratory reported that *regulates* [TNF] activation of the Raf/mitogen activated protein (MAP) kinase/extracellular signal regulated kinase ( ERK ) kinase/ERK signaling cassette by threonine phosphorylation of Raf-1 , regulating proliferation and differentiation pathways . Regulation TNF LAMB1 15793118 1386903 and ABLC decreased or did not *affect* IL-1beta and [TNF-alpha] , whereas ABLC additionally decreased MIP-1beta . Regulation TNF LAMB2 15793118 1386904 and ABLC decreased or did not *affect* IL-1beta and [TNF-alpha] , whereas ABLC additionally decreased MIP-1beta . Regulation TNF LAMB3 15793118 1386905 and ABLC decreased or did not *affect* IL-1beta and [TNF-alpha] , whereas ABLC additionally decreased MIP-1beta . Regulation TNF LAMB4 15793118 1386906 and ABLC decreased or did not *affect* IL-1beta and [TNF-alpha] , whereas ABLC additionally decreased MIP-1beta . Regulation TNF LANCL1 12871593 1114120 The present study was undertaken to explore the *role* of interleukin-12 (IL-12) in the expression of [TNF-alpha] in microglia . Regulation TNF LBP 7543211 314244 In this study we examined the *involvement* of human serum , recombinant ( rLBP ) , recombinant ( r ) CD14 , CD14 antibodies and recombinant bactericidal permeability increasing factor ( rBPI ) in the induction of [TNF] by Salmonella minnesota LPS of different polysaccharide chain lengths . Regulation TNF LEO1 12381675 997383 The lipid mediator *plays* an important role in the phagocytosis of particles , including bacteria , and consequent production of pro-inflammatory cytokines , such as [TNF-alpha] and IL-8 . Regulation TNF LEO1 15316260 1286204 The aim of this study was to determine [tumor necrosis factor alpha (TNF-alpha)] and interleukin-6 (IL-6) release in *response* to induction in peripheral blood mononuclear cells ( PBMCs ) from chronic hepatitis B virus ( HBV ) carriers . Regulation TNF LEO1 15316260 1286224 Compared with group A , PBMCs from naturally immune subjects and chronic HBV carriers produced significantly higher amounts of [TNF-alpha] and IL-6 in *response* to . Regulation TNF LEO1 1613396 191117 Moreover , 6 day- or 7 day differentiated HL-60 cells showed a further increase in [TNF] production in *response* to , and the response was bimodal , similar to that of the less dense subset of monocytes , with peaks at 10 ( -14 ) and 10 ( -7 ) M PAF . Regulation TNF LEO1 1668107 176696 The *effect* of and of two specific PAF antagonists on [tumor necrosis factor (TNF)] induced superoxide production by human polymorphonuclear neutrophils ( PMN ) was examined . Regulation TNF LEO1 1873355 165254 Further , the *role* of released in response to a challenge with LPS in the regulation of [TNF] and IL-6 production was investigated . Regulation TNF LEO1 1873355 165264 *played* a central role in the [TNF] release in the in vitro experiments . Regulation TNF LEO1 2545780 114303 The *effect* of on [TNF] production by rat alveolar macrophages ( AM ) and the role of endogenous leukotriene B4 (LTB4) in this regulation were examined . Regulation TNF LEO1 7821968 285561 In the present study we investigated the *effects* of endotoxin and on [TNF] gene expression . Regulation TNF LEO1 8009983 243910 The results showed that might *play* an important role in the production of [TNF] . Regulation TNF LEO1 8423096 210793 It was concluded that *plays* an important role in endotoxin induced [TNF] production and mortality . Regulation TNF LEO1 8653713 364654 The effect of platelet activating factor (PAF) on experimental pulmonary metastasis by the B16F10 murine melanoma and the possible *involvement* of in the activities of [tumor necrosis factor alpha (TNF-alpha)] and interleukin 1alpha (IL-1alpha) in tumor metastasis were investigated . Regulation TNF LEP 15457925 1301483 The purpose of the study was to evaluate the *effects* of on renal tissue [TNF-alpha] , malondialdehyde ( MDA ) , protein carbonyls ( PCs ) and total sulfydryl group ( SH ) levels , and plasma nitrite levels after renal I/R injury in rats . Regulation TNF LEP 15979653 1428397 Here we showed the *effects* of on the production of [TNF-alpha] ( tumor necrosis factor-alpha ) by Kupffer cells (KCs) with signal transduction . Regulation TNF LEP 20607056 2286355 The purpose of this study was to investigate the *effect* of on Prevotella ( P. ) intermedia lipopolysaccharide (LPS) induced [tumor necrosis factor (TNF)-alpha] production in differentiated THP-1 cells , a human monocytic cell line . Regulation TNF LEP 20607056 2286358 *Effect* of on P. intermedia LPS induced [TNF-alpha] production was not mediated by the leptin receptor . Regulation TNF LGALS3 22893213 2682727 Although galectin-3 is generally considered to be a pro-inflammatory molecule , here we show that the exogenously added does not *affect* interleukin (IL)-1ß , IL-6 , IL-8 , IL-10 , IL-12p70 and [TNF-a] production in resting and LPS activated monocyte-like THP-1 cells nor influences its own gene expression level in those cells . Regulation TNF LHCGR 24490570 2884835 This study focused on the protective *effect* of on [tumor necrosis factor-alpha (TNF-alpha)] and D-GalN induced hepatocyte apoptosis . Regulation TNF LITAF 10200294 605498 Together , these findings suggest that *plays* an important role in the activation of the human [TNF-alpha] gene and proposes a new mechanism to control TNF-alpha gene expression . Regulation TNF LITAF 15025820 1222453 Taken together , these results highlight the important *role* of in the regulation of [TNF-alpha] gene expression and suggest a potential role of LITAF in mouse organogenesis . Regulation TNF LITAF 16466659 1581736 We conclude that chicken may *play* an important role in the regulation of [TNF-alpha] gene expression during the course of coccidiosis or tumorigenesis . Regulation TNF LITAF 18554501 1929384 Lipopolysaccharide induced TNF-alpha factor ( ) , a transcription factor , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Regulation TNF LNPEP 8260704 238867 In addition , had little *effect* on the production of either IL-2 or [tumor necrosis factor] . Regulation TNF LPA 10394297 627356 They show that with a panel of macrophage-like cell lines of varying maturation ( P388D , THP-1 , U937 , HL-60 ) , the ability to produce TNF alpha spontaneously and to synthesize [TNF alpha] in *response* to atherogenic low-density stimulation correlates with the degree of cell differentiation that can be in turn induced by agents such as phorbol myristic acetate . Regulation TNF LPA 24321067 2880203 To explore the *effects* of oxidized low-density ( ox-LDL ) on P65 , P50 , [tumor necrosis factor-alpha] ( TNF-a ) and interleukin 6 (IL-6) of human umbilical vein endothelial cells ( HUVECs ) . Regulation TNF LPL 15994321 1446926 Differential *effects* of on [tumor necrosis factor-alpha] and interferon-gamma mediated gene expression in human endothelial cells . Regulation TNF LPL 15994321 1446928 We examined the *role* of in modulating [tumor necrosis factor-alpha (TNF-alpha)-] and interferon-gamma (IFN-gamma) mediated inflammatory cytokine signal transduction pathways in human aortic endothelial cells ( HAECs ) . Regulation TNF LPL 8169531 255045 These results show that the [TNF alpha] gene induction in *response* to involves both transcriptional activation and the enhancement of TNF alpha mRNA stability . Regulation TNF LRPAP1 18438857 1915468 [TNFalpha] *regulates* the expression and/or DNA binding potential of key positive acting and negative acting transcription factors that control the expression of the cartilage matrix gene , . Regulation TNF LRPPRC 10722865 677302 The complex of IL-6+sIL-6R and Hyper-IL-6 inhibited significantly the production of [TNF] in a *dependent* manner , whereas no differences in IFN-gamma expression were found . Regulation TNF LRRFIP1 24567534 2924719 Noncoding RNAs and *regulate* [TNF] expression . Regulation TNF LRRN2 24679734 2930916 RW stimulation of the murine macrophage cell line RAW264.7 was used to determine *effects* of ASHMI active compound on [tumor necrosis factor a (TNF-a)] production and regulation of phosphorylated I?B and histone deacetylase 2 (HDAC2) levels . Regulation TNF LSS 19122175 2037074 The finding that *dependent* reduction of [TNF-alpha] generation and HO-1 induction were abrogated by the selective inhibitor of COX-2 NS-398 , the nonselective COX inhibitor aspirin , or the specific prostacyclin receptor ( IP ) antagonist RO3244794 illuminates the central role played by LSS induced COX-2 dependent prostacyclin in restraining endothelial inflammation . Regulation TNF LTA 11435497 832575 The PKC inhibitor H7 reduced *dependent* secretion of [TNF-alpha] by 94 % but inhibited poly I:C dependent TNF-alpha production only by 50 % . Regulation TNF LTA 11861934 917416 To evaluate in vitro activation of the neonatal immune system by specific infectious stimuli , cord blood cells from healthy neonates were examined for expression of [tumor necrosis factor-alpha (TNF-alpha)] , IL-1beta , IL-6 , and IL-8 in *response* to Streptococcus agalactiae ( GBS ) , lipopolysaccharide (LPS) , and . Regulation TNF LTA 15146415 1247787 Anti-FcgammaRIII antibody stimulation markedly enhanced the induced [TNFalpha] *response* . Regulation TNF LTA 19250703 2182414 These cells showed capacity to release [TNF-alpha] and IL-10 in *response* to all assayed in a dose dependent way . Regulation TNF LTA 22956655 2688286 Anti-inflammatory SMAMPs prevented the induction of [tumor necrosis factor (TNF)] , interleukin 6 (IL-6) , and IL-10 in *response* to S. aureus or , but no other TLR2 ligands . Regulation TNF LTB 11908571 923607 The effect of antiinflammatory cytokines rhIL-4 , IL-10 , and IL-13 on basal and *dependent* stimulation of [IL-1beta/TNF-alpha] synthesis was studied under titration conditions . Regulation TNF LTB 11908571 923615 The antiinflammatory cytokine IL-4 blocked *dependent* stimulation of IL-1beta and [TNF-alpha] synthesis . Regulation TNF LTB 24913232 2946499 In vitro , neutrophils adherent to ICAM-1 or ICAM-2 rapidly released [TNF] in *response* to , C5a , and KC . Regulation TNF LTB 2540688 110423 We next examined the *role* of in mineral-dust induced [TNF] production . Regulation TNF LTF 10580998 570178 *Effect* of on the production of [tumor necrosis factor-alpha] and nitric oxide . Regulation TNF LTF 10580998 570179 We have tested the *effect* of on the productions of [tumor necrosis factor-alpha] and nitric oxide in some cells . Regulation TNF LTF 12699428 1081586 IL-1beta induced Langerhans ' cell migration and [TNF-alpha] production in human skin : *regulation* by . Regulation TNF LTF 12861396 1111736 The aim of this study was to evaluate *effects* of bovine ( BLF ) on histopathological changes in the liver of 14 day obstructive jaundiced ( OJ ) rats and production of tumor necrosis factor ( [TNF-alpha] ) and interleukin 6 (IL-6) by splenocytes from 7- and 14-day OJ rats . Regulation TNF LY86 12854734 1110275 The *effect* of , which interferes with expression of CD14 and , hence , with signaling by LPS via the CD14-tlr4 complex , on [TNF-alpha] + IFN-gamma was tested . Regulation TNF LYN 22302035 2624199 Analyzing two local MC-dependent innate immune responses in vivo , we found that positively *controls* early [TNF-a] production and immune cell recruitment after an intraperitoneal injection of LPS . Regulation TNF LYN 22302035 2624202 Our results indicate that *plays* a positive role in TLR4 induced production of [TNF-a] in MCs controlling the activity of the TRAF-6/TAK-1 protein complex . Regulation TNF MAFB 22820162 2646125 Retinoic acid and [tumor necrosis factor-a] induced monocytic cell gene expression is *regulated* in part by induction of . Regulation TNF MAGEA1 15944290 1416152 Human scFv-G8 ( POS ) T lymphocytes comprising the gamma + CD28 vs the gamma signaling element alone produced substantially more IL-2 , [TNF-alpha] , and IFN-gamma in *response* to ( POS ) melanoma cells . Regulation TNF MAL 18070880 1861745 In this study we examined whether tyrosine phosphorylation of *regulates* its interactions with TLR4 , MyD88 , interleukin-1 (IL-1) receptor associated kinase ( IRAK)-2 , and [tumor necrosis factor] receptor associated factor ( TRAF)-6 and is important for signaling . Regulation TNF MALT1 11032360 740262 In the present study we investigated the *effect* of dehydroepiandrosterone ( DHEA ) , , or DHEA + MLT on production of lethal toxin induced [TNF-alpha] in mouse peritoneal macrophages . Regulation TNF MALT1 12716016 1083712 The *effect* of on the brain levels of [tumor necrosis factor alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) in Venezuelan equine encephalomyelitis ( VEE ) virus infection was determined . Regulation TNF MAP2K1 24151609 2859745 [TNF] a mediated IL-6 secretion is *regulated* by JAK/STAT pathway but not by phosphorylation and AKT phosphorylation in U266 multiple myeloma cells . Regulation TNF MAP2K1 25131930 2957318 Hepatitis C virus core protein enhances HIV-1 replication in human macrophages through TLR2 , JNK , and *dependent* upregulation of [TNF-a] and IL-6 . Regulation TNF MAP2K2 24151609 2859746 [TNF] a mediated IL-6 secretion is *regulated* by JAK/STAT pathway but not by phosphorylation and AKT phosphorylation in U266 multiple myeloma cells . Regulation TNF MAP2K3 24151609 2859747 [TNF] a mediated IL-6 secretion is *regulated* by JAK/STAT pathway but not by phosphorylation and AKT phosphorylation in U266 multiple myeloma cells . Regulation TNF MAP2K4 21849907 2496024 Its suppressive effect on [TNF-a] , I-309 , and IP-10 may , at least in part , *involve* the down-regulation of LPS induced expression . Regulation TNF MAP2K4 24151609 2859748 [TNF] a mediated IL-6 secretion is *regulated* by JAK/STAT pathway but not by phosphorylation and AKT phosphorylation in U266 multiple myeloma cells . Regulation TNF MAP2K5 11274363 797654 *Role* of in the regulation of [TNF-alpha] gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells . Regulation TNF MAP2K5 21166929 2385278 We assessed *effects* of on [TNF] responses using qRT-PCR , FACS and measurements of HDMEC monolayer electrical resistance . Regulation TNF MAP2K5 24151609 2859749 [TNF] a mediated IL-6 secretion is *regulated* by JAK/STAT pathway but not by phosphorylation and AKT phosphorylation in U266 multiple myeloma cells . Regulation TNF MAP2K6 24151609 2859750 [TNF] a mediated IL-6 secretion is *regulated* by JAK/STAT pathway but not by phosphorylation and AKT phosphorylation in U266 multiple myeloma cells . Regulation TNF MAP2K7 11274363 797660 However , FcepsilonRI induced activation of the [tumor necrosis factor-alpha (TNF-alpha)] gene promoter is not *affected* by expression of kinase-inactive . Regulation TNF MAP2K7 24151609 2859751 [TNF] a mediated IL-6 secretion is *regulated* by JAK/STAT pathway but not by phosphorylation and AKT phosphorylation in U266 multiple myeloma cells . Regulation TNF MAP3K2 11274363 797655 *Role* of in the regulation of [TNF-alpha] gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells . Regulation TNF MAP3K3 12065326 954397 Gab1 associated with MEKK3 , and a catalytically inactive form of MEKK3 inhibited TNF-alpha induced c-Jun and NF-kappaB transcriptional activation , suggesting a critical *role* for Gab1 and in [TNF-alpha] signaling . Regulation TNF MAP3K3 12947019 1151673 These results suggest that SHP-2 is a key mediator for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , signaling , and subsequent adhesion molecule expression . Regulation TNF MAP3K5 20716917 2181798 [Tumor necrosis factor-alpha] and *control* reactive oxygen species release , mitochondrial autophagy , and c-Jun N-terminal kinase/p38 phosphorylation during necrotizing enterocolitis . Regulation TNF MAP3K7 10187861 603065 Furthermore , [tumor necrosis factor-alpha] activated endogenous TAK1 , and the kinase negative *acted* as a dominant negative inhibitor against tumor necrosis factor-alpha induced NF-kappaB activation . Regulation TNF MAP3K7 17052891 1683809 In this study , a critical *role* for in IL-1alpha or [TNFalpha] stimulated MAPK and NFkappaB activation was confirmed by inhibition of the nuclear accumulation of NFkappaB p65 and phosphorylated forms of c-Jun and p38 following siRNA mediated TAK1 silencing . Regulation TNF MAP3K7 21335610 2443391 In general , crucially *regulates* IL-1 and [TNF] signalling in fibroblasts . Regulation TNF MAP3K8 15575964 1347776 Animal and tissue culture studies have shown that is *involved* in interleukin-2 (IL-2) and [tumor necrosis factor-alpha (TNF-alpha)] production by T-cells contributing to T-cell proliferation . Regulation TNF MAP3K8 16356459 1526420 is a member of the mitogen activated protein kinase kinase kinase family of enzymes and *plays* a pivotal role in [tumor necrosis factor-alpha] production in macrophages . Regulation TNF MAP3K8 19689369 2126540 kinase activation *plays* an integral role in the production of pro-inflammatory cytokines such as [TNF] and IL-1beta in this immune cell type . Regulation TNF MAP3K8 19933865 2172090 Surprisingly , TNF production in response to infection was not significantly impaired , even though has been implicated in the *regulation* of [TNF] . Regulation TNF MAP4K5 9754676 535209 Moreover , had a significant inhibitory *effect* on anti-DNP IgE induced [tumor necrosis factor-alpha (TNF-alpha)] secretion from RPMC . Regulation TNF MAPK1 10329111 613037 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Regulation TNF MAPK1 10433212 633953 Intracellular signaling in rat cultured vascular smooth muscle cells : *roles* of nuclear factor-kappaB and p38 on [tumor necrosis factor-alpha] production . Regulation TNF MAPK1 10464169 640307 Therefore , both PI 3-K and p38 signaling pathways *control* [TNF-alpha] production in T cells . Regulation TNF MAPK1 10620700 657706 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Regulation TNF MAPK1 10655266 663550 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Regulation TNF MAPK1 10783388 707831 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Regulation TNF MAPK1 11076936 786262 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Regulation TNF MAPK1 11299196 803174 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Regulation TNF MAPK1 11544323 855318 Mycobacteria induced [TNF-alpha] and IL-10 formation by human macrophages is differentially *regulated* at the level of activity . Regulation TNF MAPK1 11675371 873185 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Regulation TNF MAPK1 11675405 873345 It is likely that cAMP-PKA and ( p42/p44 , p38 ) may *play* a critical role in the regulation of the Stx-2 induced [TNF-alpha] transcription via beta(2)-adrenoceptor activation . Regulation TNF MAPK1 11699878 878412 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Regulation TNF MAPK1 11715476 581280 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Regulation TNF MAPK1 11728947 884779 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Regulation TNF MAPK1 11795313 892306 [TNF] *regulates* gene expression in EC , in part , by stimulating which phosphorylate transcription factors . Regulation TNF MAPK1 11815388 907616 These results indicate that the MAPK pathway and mediated *regulation* of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Regulation TNF MAPK1 11833090 910293 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of [TNF-alpha] in spleen , and p38 may be *involved* in its signal transduction mechanisms . Regulation TNF MAPK1 11834148 892984 Regulative *effect* of on release of [TNFalpha] and NO from alveolar macrophages under endotoxin stimulation . Regulation TNF MAPK1 11834148 892998 SB203580 , a specific inhibitor of P38MAPK , was used with gradient concentration to evaluate the regulative *effect* of on the release of [TNFalpha] and NO from AM . Regulation TNF MAPK1 12032367 948079 p38 *plays* a role in postburn cardiomyocyte [tumor necrosis factor-alpha] secretion and cardiac dysfunction . Regulation TNF MAPK1 12506117 1056938 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Regulation TNF MAPK1 12543078 1028739 Together , the p43 induced [TNF] production was *controlled* by NFkB , p38 , and ERK that is dependent on the activities of PLC and PKC . Regulation TNF MAPK1 12734378 1087364 Our results indicate that A beta induced expression of cytokines ( [TNF-alpha] and IL-1 beta ) and chemokines ( MCP-1 , IL-8 , and MIP-1 beta ) in THP-1 monocytes *involves* activation of and downstream activation of Egr-1 . Regulation TNF MAPK1 12760489 895664 However , a specific inhibitor of p38 , SB203580 , had no *effect* on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Regulation TNF MAPK1 14764603 1235136 Moreover , [TNF-alpha] produced inhibitor kappaB kinase (IKK)-beta activation and inhibitor kappaB-beta and -alpha degradation in a p38 *dependent* manner , and treatment with salicylate ( an inhibitor of IKK ) completely restored insulin signaling . Regulation TNF MAPK1 15557189 1340380 A novel mechanism for [TNF-alpha] *regulation* by p38 : involvement of NF-kappa B with implications for therapy in rheumatoid arthritis . Regulation TNF MAPK1 15557189 1340419 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Regulation TNF MAPK1 15557189 1340445 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Regulation TNF MAPK1 15614136 1357471 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Regulation TNF MAPK1 15650061 1395188 [TNF-alpha] increased PDE2 expression in a p38 *dependent* manner . Regulation TNF MAPK1 15833800 1425447 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Regulation TNF MAPK1 16081599 1460389 These results indicate that gp120 elicited [TNF-alpha] production by macrophages involves chemokine receptor mediated PI-3K and MAPK activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and independently *regulate* TNF-alpha production . Regulation TNF MAPK1 16231199 1470324 The ( p38-MAPK ) *plays* a key role in lipopolysaccharide induced [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 (IL-1) release during the inflammatory process , emerging as an attractive target for new anti-inflammatory agents . Regulation TNF MAPK1 16480618 1496075 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Regulation TNF MAPK1 16480618 1496114 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Regulation TNF MAPK1 16581537 1543746 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Regulation TNF MAPK1 17074860 1675462 p38 *controls* NF-kappaB transcriptional activation and [tumor necrosis factor] alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation TNF MAPK1 17117477 1677378 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Regulation TNF MAPK1 17138860 1653581 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Regulation TNF MAPK1 17139186 1693710 *Effects* of inhibitors on [tumor necrosis factor-alpha] gene expression and apoptosis induction in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK1 17139186 1693723 We investigated the *involvement* of p38 in [tumor necrosis factor (TNF)-alpha] gene expression , apoptosis induction and virus replication in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK1 17151142 1732351 [TNF-alpha] *regulates* myogenesis and muscle regeneration by activating p38 . Regulation TNF MAPK1 17356569 1821787 Furthermore , pretreatment with IPT prevented rotenone induced mitochondrial membrane potential loss and p38/c-jun N-terminal kinase ( JNK ) activation in microglia , which might in turn *regulate* microglial activation and subsequent production of [TNF-alpha] and PGE ( 2 ) . Regulation TNF MAPK1 17902045 1835084 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Regulation TNF MAPK1 17934341 1813494 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Regulation TNF MAPK1 18207479 1876668 [TNFalpha] signaling *involves* PI-3-kinase (PI3K)/protein kinase B (PKB) , and which are important in NF-kappaB activation . Regulation TNF MAPK1 18314537 1919441 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Regulation TNF MAPK1 18622138 1984381 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Regulation TNF MAPK1 18675993 2011350 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Regulation TNF MAPK1 18841980 1981878 Moreover , we found that extracellular signal regulated kinase 1/2 , Jun N-terminal kinase 1/2 , and p38 *play* important roles in the regulation of [TNFalpha] secretion in ZPF1 stimulated macrophages . Regulation TNF MAPK1 19040616 2017428 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Regulation TNF MAPK1 19250666 2055398 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Regulation TNF MAPK1 19287189 2046614 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Regulation TNF MAPK1 19493203 2091434 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Regulation TNF MAPK1 19666677 2144080 Western blot analysis did not demonstrate the *involvement* of Akt or in [TNF-PostC] , whereas STAT-3 phosphorylation was increased in both IPostC and TNF-PostC . Regulation TNF MAPK1 20068037 2235168 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Regulation TNF MAPK1 20589681 2334372 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Regulation TNF MAPK1 21208554 2374426 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Regulation TNF MAPK1 21208554 2374452 The activation of p38 *plays* an important role in [TNF-a] expression in LPS stimulated cardiomyocytes and the increase of ROS production is prerequisite for the activation of p38 MAPK . Regulation TNF MAPK1 21402598 2426936 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Regulation TNF MAPK1 21819972 2490409 By using selective inhibitors of MAPKs , this study confirms that both activated p38/MK2 pathways and ERK1/2 *play* a significant role in regulation of both [TNF-a] and IL-6 protein production induced by DMXAA at the post-transcriptional level . Regulation TNF MAPK1 23557259 2777814 The p38 MAPK activation and [TNF-a] production were *controlled* by p38 and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation TNF MAPK1 7722327 301805 These results indicate that [TNF] signaling *involves* activation of . Regulation TNF MAPK1 9148963 430060 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Regulation TNF MAPK1 9418855 480538 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Regulation TNF MAPK1 9864164 582652 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Regulation TNF MAPK10 10329111 613038 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Regulation TNF MAPK10 10433212 633954 Intracellular signaling in rat cultured vascular smooth muscle cells : *roles* of nuclear factor-kappaB and p38 on [tumor necrosis factor-alpha] production . Regulation TNF MAPK10 10464169 640308 Therefore , both PI 3-K and p38 signaling pathways *control* [TNF-alpha] production in T cells . Regulation TNF MAPK10 10620700 657707 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Regulation TNF MAPK10 10655266 663551 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Regulation TNF MAPK10 10783388 707832 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Regulation TNF MAPK10 11076936 786263 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Regulation TNF MAPK10 11299196 803175 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Regulation TNF MAPK10 11544323 855319 Mycobacteria induced [TNF-alpha] and IL-10 formation by human macrophages is differentially *regulated* at the level of activity . Regulation TNF MAPK10 11675371 873186 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Regulation TNF MAPK10 11675405 873346 It is likely that cAMP-PKA and ( p42/p44 , p38 ) may *play* a critical role in the regulation of the Stx-2 induced [TNF-alpha] transcription via beta(2)-adrenoceptor activation . Regulation TNF MAPK10 11699878 878413 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Regulation TNF MAPK10 11715476 581281 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Regulation TNF MAPK10 11728947 884780 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Regulation TNF MAPK10 11795313 892307 [TNF] *regulates* gene expression in EC , in part , by stimulating which phosphorylate transcription factors . Regulation TNF MAPK10 11815388 907617 These results indicate that the pathway and MAPK mediated *regulation* of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Regulation TNF MAPK10 11833090 910294 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of [TNF-alpha] in spleen , and p38 may be *involved* in its signal transduction mechanisms . Regulation TNF MAPK10 11834148 892985 Regulative *effect* of on release of [TNFalpha] and NO from alveolar macrophages under endotoxin stimulation . Regulation TNF MAPK10 11834148 892999 SB203580 , a specific inhibitor of P38MAPK , was used with gradient concentration to evaluate the regulative *effect* of on the release of [TNFalpha] and NO from AM . Regulation TNF MAPK10 12032367 948080 p38 *plays* a role in postburn cardiomyocyte [tumor necrosis factor-alpha] secretion and cardiac dysfunction . Regulation TNF MAPK10 12506117 1056939 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Regulation TNF MAPK10 12543078 1028740 Together , the p43 induced [TNF] production was *controlled* by NFkB , p38 , and ERK that is dependent on the activities of PLC and PKC . Regulation TNF MAPK10 12760489 895665 However , a specific inhibitor of p38 , SB203580 , had no *effect* on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Regulation TNF MAPK10 14764603 1235137 Moreover , [TNF-alpha] produced inhibitor kappaB kinase (IKK)-beta activation and inhibitor kappaB-beta and -alpha degradation in a p38 *dependent* manner , and treatment with salicylate ( an inhibitor of IKK ) completely restored insulin signaling . Regulation TNF MAPK10 15557189 1340381 A novel mechanism for [TNF-alpha] *regulation* by p38 : involvement of NF-kappa B with implications for therapy in rheumatoid arthritis . Regulation TNF MAPK10 15557189 1340420 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Regulation TNF MAPK10 15557189 1340446 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Regulation TNF MAPK10 15614136 1357472 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Regulation TNF MAPK10 15650061 1395189 [TNF-alpha] increased PDE2 expression in a p38 *dependent* manner . Regulation TNF MAPK10 15833800 1425448 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Regulation TNF MAPK10 16081599 1460390 These results indicate that gp120 elicited TNF-alpha production by macrophages involves chemokine receptor mediated PI-3K and MAPK activation , that PI-3K is an upstream regulator of in this pathway , and that p38 and ERK-1/2 independently *regulate* [TNF-alpha] production . Regulation TNF MAPK10 16231199 1470325 The ( p38-MAPK ) *plays* a key role in lipopolysaccharide induced [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 (IL-1) release during the inflammatory process , emerging as an attractive target for new anti-inflammatory agents . Regulation TNF MAPK10 16480618 1496076 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Regulation TNF MAPK10 16480618 1496115 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Regulation TNF MAPK10 16581537 1543747 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Regulation TNF MAPK10 17074860 1675463 p38 *controls* NF-kappaB transcriptional activation and [tumor necrosis factor] alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation TNF MAPK10 17117477 1677379 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Regulation TNF MAPK10 17138860 1653582 The purpose of this study was to determine whether the , ERK1/2 , and p38 MAPK are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Regulation TNF MAPK10 17139186 1693711 *Effects* of inhibitors on [tumor necrosis factor-alpha] gene expression and apoptosis induction in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK10 17139186 1693724 We investigated the *involvement* of p38 in [tumor necrosis factor (TNF)-alpha] gene expression , apoptosis induction and virus replication in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK10 17151142 1732352 [TNF-alpha] *regulates* myogenesis and muscle regeneration by activating p38 . Regulation TNF MAPK10 17356569 1821788 Furthermore , pretreatment with IPT prevented rotenone induced mitochondrial membrane potential loss and p38/c-jun N-terminal kinase ( JNK ) activation in microglia , which might in turn *regulate* microglial activation and subsequent production of [TNF-alpha] and PGE ( 2 ) . Regulation TNF MAPK10 17902045 1835085 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Regulation TNF MAPK10 17934341 1813495 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Regulation TNF MAPK10 18314537 1919442 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Regulation TNF MAPK10 18622138 1984382 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Regulation TNF MAPK10 18675993 2011351 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Regulation TNF MAPK10 18841980 1981879 Moreover , we found that extracellular signal regulated kinase 1/2 , Jun N-terminal kinase 1/2 , and p38 *play* important roles in the regulation of [TNFalpha] secretion in ZPF1 stimulated macrophages . Regulation TNF MAPK10 19040616 2017429 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Regulation TNF MAPK10 19250666 2055399 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Regulation TNF MAPK10 19287189 2046615 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Regulation TNF MAPK10 19493203 2091435 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Regulation TNF MAPK10 20068037 2235169 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Regulation TNF MAPK10 20589681 2334373 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Regulation TNF MAPK10 21208554 2374427 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Regulation TNF MAPK10 21208554 2374453 The activation of p38 *plays* an important role in [TNF-a] expression in LPS stimulated cardiomyocytes and the increase of ROS production is prerequisite for the activation of p38 MAPK . Regulation TNF MAPK10 21402598 2426937 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Regulation TNF MAPK10 21819972 2490410 By using selective inhibitors of MAPKs , this study confirms that both activated p38/MK2 pathways and ERK1/2 *play* a significant role in regulation of both [TNF-a] and IL-6 protein production induced by DMXAA at the post-transcriptional level . Regulation TNF MAPK10 23557259 2777815 The p38 MAPK activation and [TNF-a] production were *controlled* by p38 and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation TNF MAPK10 7722327 301806 These results indicate that [TNF] signaling *involves* activation of . Regulation TNF MAPK10 9148963 430061 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Regulation TNF MAPK10 9418855 480539 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Regulation TNF MAPK10 9864164 582653 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Regulation TNF MAPK11 10329111 613039 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Regulation TNF MAPK11 10433212 633955 Intracellular signaling in rat cultured vascular smooth muscle cells : *roles* of nuclear factor-kappaB and p38 on [tumor necrosis factor-alpha] production . Regulation TNF MAPK11 10464169 640309 Therefore , both PI 3-K and p38 signaling pathways *control* [TNF-alpha] production in T cells . Regulation TNF MAPK11 10620700 657708 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Regulation TNF MAPK11 10655266 663552 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Regulation TNF MAPK11 10783388 707833 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Regulation TNF MAPK11 11076936 786264 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Regulation TNF MAPK11 11299196 803176 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Regulation TNF MAPK11 11544323 855320 Mycobacteria induced [TNF-alpha] and IL-10 formation by human macrophages is differentially *regulated* at the level of activity . Regulation TNF MAPK11 11675371 873187 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Regulation TNF MAPK11 11675405 873347 It is likely that cAMP-PKA and ( p42/p44 , p38 ) may *play* a critical role in the regulation of the Stx-2 induced [TNF-alpha] transcription via beta(2)-adrenoceptor activation . Regulation TNF MAPK11 11699878 878414 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Regulation TNF MAPK11 11715476 581282 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Regulation TNF MAPK11 11728947 884781 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Regulation TNF MAPK11 11795313 892308 [TNF] *regulates* gene expression in EC , in part , by stimulating which phosphorylate transcription factors . Regulation TNF MAPK11 11815388 907618 These results indicate that the pathway and MAPK mediated *regulation* of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Regulation TNF MAPK11 11833090 910295 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of [TNF-alpha] in spleen , and p38 may be *involved* in its signal transduction mechanisms . Regulation TNF MAPK11 11834148 892986 Regulative *effect* of on release of [TNFalpha] and NO from alveolar macrophages under endotoxin stimulation . Regulation TNF MAPK11 11834148 893000 SB203580 , a specific inhibitor of P38MAPK , was used with gradient concentration to evaluate the regulative *effect* of on the release of [TNFalpha] and NO from AM . Regulation TNF MAPK11 12032367 948081 p38 *plays* a role in postburn cardiomyocyte [tumor necrosis factor-alpha] secretion and cardiac dysfunction . Regulation TNF MAPK11 12506117 1056940 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Regulation TNF MAPK11 12543078 1028741 Together , the p43 induced [TNF] production was *controlled* by NFkB , p38 , and ERK that is dependent on the activities of PLC and PKC . Regulation TNF MAPK11 12760489 895666 However , a specific inhibitor of p38 , SB203580 , had no *effect* on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Regulation TNF MAPK11 14764603 1235138 Moreover , [TNF-alpha] produced inhibitor kappaB kinase (IKK)-beta activation and inhibitor kappaB-beta and -alpha degradation in a p38 *dependent* manner , and treatment with salicylate ( an inhibitor of IKK ) completely restored insulin signaling . Regulation TNF MAPK11 15557189 1340382 A novel mechanism for [TNF-alpha] *regulation* by p38 : involvement of NF-kappa B with implications for therapy in rheumatoid arthritis . Regulation TNF MAPK11 15557189 1340421 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Regulation TNF MAPK11 15557189 1340447 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Regulation TNF MAPK11 15614136 1357473 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Regulation TNF MAPK11 15650061 1395190 [TNF-alpha] increased PDE2 expression in a p38 *dependent* manner . Regulation TNF MAPK11 15833800 1425449 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Regulation TNF MAPK11 16081599 1460391 These results indicate that gp120 elicited [TNF-alpha] production by macrophages *involves* chemokine receptor mediated PI-3K and activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and ERK-1/2 independently regulate TNF-alpha production . Regulation TNF MAPK11 16231199 1470326 The ( p38-MAPK ) *plays* a key role in lipopolysaccharide induced [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 (IL-1) release during the inflammatory process , emerging as an attractive target for new anti-inflammatory agents . Regulation TNF MAPK11 16480618 1496077 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Regulation TNF MAPK11 16480618 1496116 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Regulation TNF MAPK11 16581537 1543748 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Regulation TNF MAPK11 17074860 1675464 p38 *controls* NF-kappaB transcriptional activation and [tumor necrosis factor] alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation TNF MAPK11 17117477 1677380 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Regulation TNF MAPK11 17138860 1653583 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Regulation TNF MAPK11 17139186 1693712 *Effects* of inhibitors on [tumor necrosis factor-alpha] gene expression and apoptosis induction in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK11 17139186 1693725 We investigated the *involvement* of p38 in [tumor necrosis factor (TNF)-alpha] gene expression , apoptosis induction and virus replication in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK11 17151142 1732353 [TNF-alpha] *regulates* myogenesis and muscle regeneration by activating p38 . Regulation TNF MAPK11 17356569 1821789 Furthermore , pretreatment with IPT prevented rotenone induced mitochondrial membrane potential loss and p38/c-jun N-terminal kinase ( JNK ) activation in microglia , which might in turn *regulate* microglial activation and subsequent production of [TNF-alpha] and PGE ( 2 ) . Regulation TNF MAPK11 17902045 1835086 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Regulation TNF MAPK11 17934341 1813496 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Regulation TNF MAPK11 18314537 1919443 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Regulation TNF MAPK11 18622138 1984383 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Regulation TNF MAPK11 18675993 2011352 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Regulation TNF MAPK11 18841980 1981880 Moreover , we found that extracellular signal regulated kinase 1/2 , Jun N-terminal kinase 1/2 , and p38 *play* important roles in the regulation of [TNFalpha] secretion in ZPF1 stimulated macrophages . Regulation TNF MAPK11 19040616 2017430 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Regulation TNF MAPK11 19250666 2055400 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Regulation TNF MAPK11 19287189 2046616 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Regulation TNF MAPK11 19493203 2091436 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Regulation TNF MAPK11 20068037 2235170 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Regulation TNF MAPK11 20589681 2334374 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Regulation TNF MAPK11 21208554 2374428 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Regulation TNF MAPK11 21208554 2374454 The activation of p38 *plays* an important role in [TNF-a] expression in LPS stimulated cardiomyocytes and the increase of ROS production is prerequisite for the activation of p38 MAPK . Regulation TNF MAPK11 21402598 2426938 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Regulation TNF MAPK11 21819972 2490411 By using selective inhibitors of MAPKs , this study confirms that both activated p38/MK2 pathways and ERK1/2 *play* a significant role in regulation of both [TNF-a] and IL-6 protein production induced by DMXAA at the post-transcriptional level . Regulation TNF MAPK11 23557259 2777816 The p38 MAPK activation and [TNF-a] production were *controlled* by p38 and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation TNF MAPK11 7722327 301807 These results indicate that [TNF] signaling *involves* activation of . Regulation TNF MAPK11 9148963 430062 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Regulation TNF MAPK11 9418855 480540 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Regulation TNF MAPK11 9864164 582654 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Regulation TNF MAPK12 10329111 613040 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Regulation TNF MAPK12 10433212 633956 Intracellular signaling in rat cultured vascular smooth muscle cells : *roles* of nuclear factor-kappaB and p38 on [tumor necrosis factor-alpha] production . Regulation TNF MAPK12 10464169 640310 Therefore , both PI 3-K and p38 signaling pathways *control* [TNF-alpha] production in T cells . Regulation TNF MAPK12 10620700 657709 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Regulation TNF MAPK12 10655266 663553 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Regulation TNF MAPK12 10783388 707834 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Regulation TNF MAPK12 11076936 786265 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Regulation TNF MAPK12 11299196 803177 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Regulation TNF MAPK12 11544323 855321 Mycobacteria induced [TNF-alpha] and IL-10 formation by human macrophages is differentially *regulated* at the level of activity . Regulation TNF MAPK12 11675371 873188 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Regulation TNF MAPK12 11675405 873348 It is likely that cAMP-PKA and ( p42/p44 , p38 ) may *play* a critical role in the regulation of the Stx-2 induced [TNF-alpha] transcription via beta(2)-adrenoceptor activation . Regulation TNF MAPK12 11699878 878415 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Regulation TNF MAPK12 11715476 581283 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Regulation TNF MAPK12 11728947 884782 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Regulation TNF MAPK12 11795313 892309 [TNF] *regulates* gene expression in EC , in part , by stimulating which phosphorylate transcription factors . Regulation TNF MAPK12 11815388 907619 These results indicate that the pathway and MAPK mediated *regulation* of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Regulation TNF MAPK12 11833090 910296 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of [TNF-alpha] in spleen , and p38 may be *involved* in its signal transduction mechanisms . Regulation TNF MAPK12 11834148 892987 Regulative *effect* of on release of [TNFalpha] and NO from alveolar macrophages under endotoxin stimulation . Regulation TNF MAPK12 11834148 893001 SB203580 , a specific inhibitor of P38MAPK , was used with gradient concentration to evaluate the regulative *effect* of on the release of [TNFalpha] and NO from AM . Regulation TNF MAPK12 12032367 948082 p38 *plays* a role in postburn cardiomyocyte [tumor necrosis factor-alpha] secretion and cardiac dysfunction . Regulation TNF MAPK12 12506117 1056941 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Regulation TNF MAPK12 12543078 1028742 Together , the p43 induced [TNF] production was *controlled* by NFkB , p38 , and ERK that is dependent on the activities of PLC and PKC . Regulation TNF MAPK12 12760489 895667 However , a specific inhibitor of p38 , SB203580 , had no *effect* on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Regulation TNF MAPK12 14764603 1235139 Moreover , [TNF-alpha] produced inhibitor kappaB kinase (IKK)-beta activation and inhibitor kappaB-beta and -alpha degradation in a p38 *dependent* manner , and treatment with salicylate ( an inhibitor of IKK ) completely restored insulin signaling . Regulation TNF MAPK12 15557189 1340383 A novel mechanism for [TNF-alpha] *regulation* by p38 : involvement of NF-kappa B with implications for therapy in rheumatoid arthritis . Regulation TNF MAPK12 15557189 1340422 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Regulation TNF MAPK12 15557189 1340448 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Regulation TNF MAPK12 15614136 1357474 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Regulation TNF MAPK12 15650061 1395191 [TNF-alpha] increased PDE2 expression in a p38 *dependent* manner . Regulation TNF MAPK12 15833800 1425450 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Regulation TNF MAPK12 16081599 1460392 These results indicate that gp120 elicited TNF-alpha production by macrophages involves chemokine receptor mediated PI-3K and MAPK activation , that PI-3K is an upstream regulator of in this pathway , and that p38 and ERK-1/2 independently *regulate* [TNF-alpha] production . Regulation TNF MAPK12 16231199 1470327 The ( p38-MAPK ) *plays* a key role in lipopolysaccharide induced [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 (IL-1) release during the inflammatory process , emerging as an attractive target for new anti-inflammatory agents . Regulation TNF MAPK12 16480618 1496078 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Regulation TNF MAPK12 16480618 1496117 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Regulation TNF MAPK12 16581537 1543749 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Regulation TNF MAPK12 17074860 1675465 p38 *controls* NF-kappaB transcriptional activation and [tumor necrosis factor] alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation TNF MAPK12 17117477 1677381 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Regulation TNF MAPK12 17138860 1653584 The purpose of this study was to determine whether the , ERK1/2 , and p38 MAPK are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Regulation TNF MAPK12 17139186 1693713 *Effects* of inhibitors on [tumor necrosis factor-alpha] gene expression and apoptosis induction in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK12 17139186 1693726 We investigated the *involvement* of p38 in [tumor necrosis factor (TNF)-alpha] gene expression , apoptosis induction and virus replication in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK12 17151142 1732354 [TNF-alpha] *regulates* myogenesis and muscle regeneration by activating p38 . Regulation TNF MAPK12 17356569 1821790 Furthermore , pretreatment with IPT prevented rotenone induced mitochondrial membrane potential loss and p38/c-jun N-terminal kinase ( JNK ) activation in microglia , which might in turn *regulate* microglial activation and subsequent production of [TNF-alpha] and PGE ( 2 ) . Regulation TNF MAPK12 17902045 1835087 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Regulation TNF MAPK12 17934341 1813497 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Regulation TNF MAPK12 18314537 1919444 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Regulation TNF MAPK12 18622138 1984384 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Regulation TNF MAPK12 18675993 2011353 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Regulation TNF MAPK12 18841980 1981881 Moreover , we found that extracellular signal regulated kinase 1/2 , Jun N-terminal kinase 1/2 , and p38 *play* important roles in the regulation of [TNFalpha] secretion in ZPF1 stimulated macrophages . Regulation TNF MAPK12 19040616 2017431 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Regulation TNF MAPK12 19250666 2055401 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Regulation TNF MAPK12 19287189 2046617 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Regulation TNF MAPK12 19493203 2091437 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Regulation TNF MAPK12 20068037 2235171 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Regulation TNF MAPK12 20589681 2334375 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Regulation TNF MAPK12 21208554 2374429 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Regulation TNF MAPK12 21208554 2374455 The activation of p38 *plays* an important role in [TNF-a] expression in LPS stimulated cardiomyocytes and the increase of ROS production is prerequisite for the activation of p38 MAPK . Regulation TNF MAPK12 21402598 2426939 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Regulation TNF MAPK12 21819972 2490412 By using selective inhibitors of MAPKs , this study confirms that both activated p38/MK2 pathways and ERK1/2 *play* a significant role in regulation of both [TNF-a] and IL-6 protein production induced by DMXAA at the post-transcriptional level . Regulation TNF MAPK12 23557259 2777817 The p38 MAPK activation and [TNF-a] production were *controlled* by p38 and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation TNF MAPK12 7722327 301808 These results indicate that [TNF] signaling *involves* activation of . Regulation TNF MAPK12 9148963 430063 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Regulation TNF MAPK12 9418855 480541 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Regulation TNF MAPK12 9864164 582655 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Regulation TNF MAPK13 10329111 613041 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Regulation TNF MAPK13 10433212 633957 Intracellular signaling in rat cultured vascular smooth muscle cells : *roles* of nuclear factor-kappaB and p38 on [tumor necrosis factor-alpha] production . Regulation TNF MAPK13 10464169 640311 Therefore , both PI 3-K and p38 signaling pathways *control* [TNF-alpha] production in T cells . Regulation TNF MAPK13 10620700 657710 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Regulation TNF MAPK13 10655266 663554 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Regulation TNF MAPK13 10783388 707835 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Regulation TNF MAPK13 11076936 786266 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Regulation TNF MAPK13 11299196 803178 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Regulation TNF MAPK13 11544323 855322 Mycobacteria induced [TNF-alpha] and IL-10 formation by human macrophages is differentially *regulated* at the level of activity . Regulation TNF MAPK13 11675371 873189 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Regulation TNF MAPK13 11675405 873349 It is likely that cAMP-PKA and ( p42/p44 , p38 ) may *play* a critical role in the regulation of the Stx-2 induced [TNF-alpha] transcription via beta(2)-adrenoceptor activation . Regulation TNF MAPK13 11699878 878416 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Regulation TNF MAPK13 11715476 581284 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Regulation TNF MAPK13 11728947 884783 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Regulation TNF MAPK13 11795313 892310 [TNF] *regulates* gene expression in EC , in part , by stimulating which phosphorylate transcription factors . Regulation TNF MAPK13 11815388 907620 These results indicate that the MAPK pathway and mediated *regulation* of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Regulation TNF MAPK13 11833090 910297 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of [TNF-alpha] in spleen , and p38 may be *involved* in its signal transduction mechanisms . Regulation TNF MAPK13 11834148 892988 Regulative *effect* of on release of [TNFalpha] and NO from alveolar macrophages under endotoxin stimulation . Regulation TNF MAPK13 11834148 893002 SB203580 , a specific inhibitor of P38MAPK , was used with gradient concentration to evaluate the regulative *effect* of on the release of [TNFalpha] and NO from AM . Regulation TNF MAPK13 12032367 948083 p38 *plays* a role in postburn cardiomyocyte [tumor necrosis factor-alpha] secretion and cardiac dysfunction . Regulation TNF MAPK13 12506117 1056942 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Regulation TNF MAPK13 12543078 1028743 Together , the p43 induced [TNF] production was *controlled* by NFkB , p38 , and ERK that is dependent on the activities of PLC and PKC . Regulation TNF MAPK13 12760489 895668 However , a specific inhibitor of p38 , SB203580 , had no *effect* on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Regulation TNF MAPK13 14764603 1235140 Moreover , [TNF-alpha] produced inhibitor kappaB kinase (IKK)-beta activation and inhibitor kappaB-beta and -alpha degradation in a p38 *dependent* manner , and treatment with salicylate ( an inhibitor of IKK ) completely restored insulin signaling . Regulation TNF MAPK13 15557189 1340384 A novel mechanism for [TNF-alpha] *regulation* by p38 : involvement of NF-kappa B with implications for therapy in rheumatoid arthritis . Regulation TNF MAPK13 15557189 1340423 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Regulation TNF MAPK13 15557189 1340449 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Regulation TNF MAPK13 15614136 1357475 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Regulation TNF MAPK13 15650061 1395192 [TNF-alpha] increased PDE2 expression in a p38 *dependent* manner . Regulation TNF MAPK13 15833800 1425451 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Regulation TNF MAPK13 16081599 1460393 These results indicate that gp120 elicited [TNF-alpha] production by macrophages *involves* chemokine receptor mediated PI-3K and activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and ERK-1/2 independently regulate TNF-alpha production . Regulation TNF MAPK13 16231199 1470328 The ( p38-MAPK ) *plays* a key role in lipopolysaccharide induced [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 (IL-1) release during the inflammatory process , emerging as an attractive target for new anti-inflammatory agents . Regulation TNF MAPK13 16480618 1496079 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Regulation TNF MAPK13 16480618 1496118 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Regulation TNF MAPK13 16581537 1543750 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Regulation TNF MAPK13 17074860 1675466 p38 *controls* NF-kappaB transcriptional activation and [tumor necrosis factor] alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation TNF MAPK13 17117477 1677382 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Regulation TNF MAPK13 17138860 1653585 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Regulation TNF MAPK13 17139186 1693714 *Effects* of inhibitors on [tumor necrosis factor-alpha] gene expression and apoptosis induction in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK13 17139186 1693727 We investigated the *involvement* of p38 in [tumor necrosis factor (TNF)-alpha] gene expression , apoptosis induction and virus replication in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK13 17151142 1732355 [TNF-alpha] *regulates* myogenesis and muscle regeneration by activating p38 . Regulation TNF MAPK13 17356569 1821791 Furthermore , pretreatment with IPT prevented rotenone induced mitochondrial membrane potential loss and p38/c-jun N-terminal kinase ( JNK ) activation in microglia , which might in turn *regulate* microglial activation and subsequent production of [TNF-alpha] and PGE ( 2 ) . Regulation TNF MAPK13 17902045 1835088 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Regulation TNF MAPK13 17934341 1813498 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Regulation TNF MAPK13 18314537 1919445 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Regulation TNF MAPK13 18622138 1984385 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Regulation TNF MAPK13 18675993 2011354 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Regulation TNF MAPK13 18841980 1981882 Moreover , we found that extracellular signal regulated kinase 1/2 , Jun N-terminal kinase 1/2 , and p38 *play* important roles in the regulation of [TNFalpha] secretion in ZPF1 stimulated macrophages . Regulation TNF MAPK13 19040616 2017432 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Regulation TNF MAPK13 19250666 2055402 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Regulation TNF MAPK13 19287189 2046618 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Regulation TNF MAPK13 19493203 2091438 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Regulation TNF MAPK13 20068037 2235172 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Regulation TNF MAPK13 20589681 2334376 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Regulation TNF MAPK13 21208554 2374430 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Regulation TNF MAPK13 21208554 2374456 The activation of p38 *plays* an important role in [TNF-a] expression in LPS stimulated cardiomyocytes and the increase of ROS production is prerequisite for the activation of p38 MAPK . Regulation TNF MAPK13 21402598 2426940 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Regulation TNF MAPK13 21819972 2490413 By using selective inhibitors of MAPKs , this study confirms that both activated p38/MK2 pathways and ERK1/2 *play* a significant role in regulation of both [TNF-a] and IL-6 protein production induced by DMXAA at the post-transcriptional level . Regulation TNF MAPK13 23557259 2777818 The p38 MAPK activation and [TNF-a] production were *controlled* by p38 and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation TNF MAPK13 7722327 301809 These results indicate that [TNF] signaling *involves* activation of . Regulation TNF MAPK13 9148963 430064 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Regulation TNF MAPK13 9418855 480542 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Regulation TNF MAPK13 9864164 582656 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Regulation TNF MAPK14 10329111 613042 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Regulation TNF MAPK14 10433212 633958 Intracellular signaling in rat cultured vascular smooth muscle cells : *roles* of nuclear factor-kappaB and p38 on [tumor necrosis factor-alpha] production . Regulation TNF MAPK14 10464169 640312 Therefore , both PI 3-K and p38 signaling pathways *control* [TNF-alpha] production in T cells . Regulation TNF MAPK14 10620700 657711 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Regulation TNF MAPK14 10655266 663555 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Regulation TNF MAPK14 10783388 707836 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Regulation TNF MAPK14 11076936 786267 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Regulation TNF MAPK14 11299196 803179 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Regulation TNF MAPK14 11544323 855323 Mycobacteria induced [TNF-alpha] and IL-10 formation by human macrophages is differentially *regulated* at the level of activity . Regulation TNF MAPK14 11675371 873190 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Regulation TNF MAPK14 11675405 873350 It is likely that cAMP-PKA and ( p42/p44 , p38 ) may *play* a critical role in the regulation of the Stx-2 induced [TNF-alpha] transcription via beta(2)-adrenoceptor activation . Regulation TNF MAPK14 11699878 878417 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Regulation TNF MAPK14 11715476 581285 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Regulation TNF MAPK14 11728947 884784 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Regulation TNF MAPK14 11795313 892311 [TNF] *regulates* gene expression in EC , in part , by stimulating which phosphorylate transcription factors . Regulation TNF MAPK14 11815388 907621 These results indicate that the pathway and MAPK mediated *regulation* of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Regulation TNF MAPK14 11833090 910298 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of [TNF-alpha] in spleen , and p38 may be *involved* in its signal transduction mechanisms . Regulation TNF MAPK14 11834148 892989 Regulative *effect* of on release of [TNFalpha] and NO from alveolar macrophages under endotoxin stimulation . Regulation TNF MAPK14 11834148 893003 SB203580 , a specific inhibitor of P38MAPK , was used with gradient concentration to evaluate the regulative *effect* of on the release of [TNFalpha] and NO from AM . Regulation TNF MAPK14 12032367 948084 p38 *plays* a role in postburn cardiomyocyte [tumor necrosis factor-alpha] secretion and cardiac dysfunction . Regulation TNF MAPK14 12506117 1056943 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Regulation TNF MAPK14 12543078 1028744 Together , the p43 induced [TNF] production was *controlled* by NFkB , p38 , and ERK that is dependent on the activities of PLC and PKC . Regulation TNF MAPK14 12760489 895669 However , a specific inhibitor of p38 , SB203580 , had no *effect* on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Regulation TNF MAPK14 14764603 1235141 Moreover , [TNF-alpha] produced inhibitor kappaB kinase (IKK)-beta activation and inhibitor kappaB-beta and -alpha degradation in a p38 *dependent* manner , and treatment with salicylate ( an inhibitor of IKK ) completely restored insulin signaling . Regulation TNF MAPK14 15557189 1340385 A novel mechanism for [TNF-alpha] *regulation* by p38 : involvement of NF-kappa B with implications for therapy in rheumatoid arthritis . Regulation TNF MAPK14 15557189 1340424 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Regulation TNF MAPK14 15557189 1340450 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Regulation TNF MAPK14 15614136 1357476 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Regulation TNF MAPK14 15650061 1395193 [TNF-alpha] increased PDE2 expression in a p38 *dependent* manner . Regulation TNF MAPK14 15833800 1425452 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Regulation TNF MAPK14 16081599 1460394 These results indicate that gp120 elicited TNF-alpha production by macrophages involves chemokine receptor mediated PI-3K and MAPK activation , that PI-3K is an upstream regulator of in this pathway , and that p38 and ERK-1/2 independently *regulate* [TNF-alpha] production . Regulation TNF MAPK14 16231199 1470329 The ( p38-MAPK ) *plays* a key role in lipopolysaccharide induced [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 (IL-1) release during the inflammatory process , emerging as an attractive target for new anti-inflammatory agents . Regulation TNF MAPK14 16480618 1496080 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Regulation TNF MAPK14 16480618 1496119 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Regulation TNF MAPK14 16581537 1543751 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Regulation TNF MAPK14 17074860 1675467 p38 *controls* NF-kappaB transcriptional activation and [tumor necrosis factor] alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation TNF MAPK14 17117477 1677383 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Regulation TNF MAPK14 17138860 1653586 The purpose of this study was to determine whether the , ERK1/2 , and p38 MAPK are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Regulation TNF MAPK14 17139186 1693715 *Effects* of inhibitors on [tumor necrosis factor-alpha] gene expression and apoptosis induction in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK14 17139186 1693728 We investigated the *involvement* of p38 in [tumor necrosis factor (TNF)-alpha] gene expression , apoptosis induction and virus replication in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK14 17151142 1732356 [TNF-alpha] *regulates* myogenesis and muscle regeneration by activating p38 . Regulation TNF MAPK14 17356569 1821792 Furthermore , pretreatment with IPT prevented rotenone induced mitochondrial membrane potential loss and p38/c-jun N-terminal kinase ( JNK ) activation in microglia , which might in turn *regulate* microglial activation and subsequent production of [TNF-alpha] and PGE ( 2 ) . Regulation TNF MAPK14 17902045 1835089 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Regulation TNF MAPK14 17934341 1813499 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Regulation TNF MAPK14 18314537 1919446 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Regulation TNF MAPK14 18622138 1984386 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Regulation TNF MAPK14 18675993 2011355 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Regulation TNF MAPK14 18841980 1981883 Moreover , we found that extracellular signal regulated kinase 1/2 , Jun N-terminal kinase 1/2 , and p38 *play* important roles in the regulation of [TNFalpha] secretion in ZPF1 stimulated macrophages . Regulation TNF MAPK14 19040616 2017433 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Regulation TNF MAPK14 19250666 2055403 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Regulation TNF MAPK14 19287189 2046619 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Regulation TNF MAPK14 19493203 2091439 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Regulation TNF MAPK14 20068037 2235173 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Regulation TNF MAPK14 20589681 2334377 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Regulation TNF MAPK14 21208554 2374431 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Regulation TNF MAPK14 21208554 2374457 The activation of p38 *plays* an important role in [TNF-a] expression in LPS stimulated cardiomyocytes and the increase of ROS production is prerequisite for the activation of p38 MAPK . Regulation TNF MAPK14 21402598 2426941 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Regulation TNF MAPK14 21819972 2490414 By using selective inhibitors of MAPKs , this study confirms that both activated p38/MK2 pathways and ERK1/2 *play* a significant role in regulation of both [TNF-a] and IL-6 protein production induced by DMXAA at the post-transcriptional level . Regulation TNF MAPK14 23557259 2777819 The p38 MAPK activation and [TNF-a] production were *controlled* by p38 and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation TNF MAPK14 7722327 301810 These results indicate that [TNF] signaling *involves* activation of . Regulation TNF MAPK14 9148963 430065 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Regulation TNF MAPK14 9418855 480543 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Regulation TNF MAPK14 9864164 582657 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Regulation TNF MAPK15 10329111 613035 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Regulation TNF MAPK15 10433212 633952 Intracellular signaling in rat cultured vascular smooth muscle cells : *roles* of nuclear factor-kappaB and p38 on [tumor necrosis factor-alpha] production . Regulation TNF MAPK15 10464169 640306 Therefore , both PI 3-K and p38 signaling pathways *control* [TNF-alpha] production in T cells . Regulation TNF MAPK15 10620700 657705 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Regulation TNF MAPK15 10655266 663548 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Regulation TNF MAPK15 10783388 707830 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Regulation TNF MAPK15 11076936 786260 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Regulation TNF MAPK15 11299196 803173 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Regulation TNF MAPK15 11544323 855317 Mycobacteria induced [TNF-alpha] and IL-10 formation by human macrophages is differentially *regulated* at the level of activity . Regulation TNF MAPK15 11675371 873184 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Regulation TNF MAPK15 11675405 873344 It is likely that cAMP-PKA and ( p42/p44 , p38 ) may *play* a critical role in the regulation of the Stx-2 induced [TNF-alpha] transcription via beta(2)-adrenoceptor activation . Regulation TNF MAPK15 11699878 878411 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Regulation TNF MAPK15 11715476 581279 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Regulation TNF MAPK15 11728947 884778 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Regulation TNF MAPK15 11795313 892305 [TNF] *regulates* gene expression in EC , in part , by stimulating which phosphorylate transcription factors . Regulation TNF MAPK15 11815388 907615 These results indicate that the pathway and MAPK mediated *regulation* of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Regulation TNF MAPK15 11833090 910292 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of [TNF-alpha] in spleen , and p38 may be *involved* in its signal transduction mechanisms . Regulation TNF MAPK15 11834148 892982 Regulative *effect* of on release of [TNFalpha] and NO from alveolar macrophages under endotoxin stimulation . Regulation TNF MAPK15 11834148 892996 SB203580 , a specific inhibitor of P38MAPK , was used with gradient concentration to evaluate the regulative *effect* of on the release of [TNFalpha] and NO from AM . Regulation TNF MAPK15 12032367 948078 p38 *plays* a role in postburn cardiomyocyte [tumor necrosis factor-alpha] secretion and cardiac dysfunction . Regulation TNF MAPK15 12506117 1056937 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Regulation TNF MAPK15 12543078 1028737 Together , the p43 induced [TNF] production was *controlled* by NFkB , p38 , and ERK that is dependent on the activities of PLC and PKC . Regulation TNF MAPK15 12760489 895663 However , a specific inhibitor of p38 , SB203580 , had no *effect* on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Regulation TNF MAPK15 14764603 1235135 Moreover , [TNF-alpha] produced inhibitor kappaB kinase (IKK)-beta activation and inhibitor kappaB-beta and -alpha degradation in a p38 *dependent* manner , and treatment with salicylate ( an inhibitor of IKK ) completely restored insulin signaling . Regulation TNF MAPK15 15557189 1340379 A novel mechanism for [TNF-alpha] *regulation* by p38 : involvement of NF-kappa B with implications for therapy in rheumatoid arthritis . Regulation TNF MAPK15 15557189 1340418 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Regulation TNF MAPK15 15557189 1340444 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Regulation TNF MAPK15 15614136 1357470 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Regulation TNF MAPK15 15650061 1395187 [TNF-alpha] increased PDE2 expression in a p38 *dependent* manner . Regulation TNF MAPK15 15833800 1425446 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Regulation TNF MAPK15 16081599 1460387 These results indicate that gp120 elicited [TNF-alpha] production by macrophages *involves* chemokine receptor mediated PI-3K and activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and ERK-1/2 independently regulate TNF-alpha production . Regulation TNF MAPK15 16231199 1470323 The ( p38-MAPK ) *plays* a key role in lipopolysaccharide induced [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 (IL-1) release during the inflammatory process , emerging as an attractive target for new anti-inflammatory agents . Regulation TNF MAPK15 16480618 1496074 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Regulation TNF MAPK15 16480618 1496113 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Regulation TNF MAPK15 16581537 1543745 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Regulation TNF MAPK15 17074860 1675461 p38 *controls* NF-kappaB transcriptional activation and [tumor necrosis factor] alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation TNF MAPK15 17117477 1677377 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Regulation TNF MAPK15 17138860 1653580 The purpose of this study was to determine whether the , ERK1/2 , and p38 MAPK are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Regulation TNF MAPK15 17139186 1693709 *Effects* of inhibitors on [tumor necrosis factor-alpha] gene expression and apoptosis induction in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK15 17139186 1693722 We investigated the *involvement* of p38 in [tumor necrosis factor (TNF)-alpha] gene expression , apoptosis induction and virus replication in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK15 17151142 1732350 [TNF-alpha] *regulates* myogenesis and muscle regeneration by activating p38 . Regulation TNF MAPK15 17356569 1821786 Furthermore , pretreatment with IPT prevented rotenone induced mitochondrial membrane potential loss and p38/c-jun N-terminal kinase ( JNK ) activation in microglia , which might in turn *regulate* microglial activation and subsequent production of [TNF-alpha] and PGE ( 2 ) . Regulation TNF MAPK15 17902045 1835083 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Regulation TNF MAPK15 17934341 1813491 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Regulation TNF MAPK15 18314537 1919440 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Regulation TNF MAPK15 18622138 1984379 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Regulation TNF MAPK15 18675993 2011349 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Regulation TNF MAPK15 18841980 1981877 Moreover , we found that extracellular signal regulated kinase 1/2 , Jun N-terminal kinase 1/2 , and p38 *play* important roles in the regulation of [TNFalpha] secretion in ZPF1 stimulated macrophages . Regulation TNF MAPK15 19040616 2017427 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Regulation TNF MAPK15 19250666 2055397 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Regulation TNF MAPK15 19287189 2046613 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Regulation TNF MAPK15 19493203 2091433 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Regulation TNF MAPK15 20068037 2235167 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Regulation TNF MAPK15 20589681 2334371 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Regulation TNF MAPK15 21208554 2374425 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Regulation TNF MAPK15 21208554 2374451 The activation of p38 *plays* an important role in [TNF-a] expression in LPS stimulated cardiomyocytes and the increase of ROS production is prerequisite for the activation of p38 MAPK . Regulation TNF MAPK15 21402598 2426935 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Regulation TNF MAPK15 21819972 2490408 By using selective inhibitors of MAPKs , this study confirms that both activated p38/MK2 pathways and ERK1/2 *play* a significant role in regulation of both [TNF-a] and IL-6 protein production induced by DMXAA at the post-transcriptional level . Regulation TNF MAPK15 23557259 2777813 The p38 MAPK activation and [TNF-a] production were *controlled* by p38 and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation TNF MAPK15 7722327 301804 These results indicate that [TNF] signaling *involves* activation of . Regulation TNF MAPK15 9148963 430059 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Regulation TNF MAPK15 9418855 480537 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Regulation TNF MAPK15 9864164 582651 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Regulation TNF MAPK3 10329111 613043 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Regulation TNF MAPK3 10433212 633959 Intracellular signaling in rat cultured vascular smooth muscle cells : *roles* of nuclear factor-kappaB and p38 on [tumor necrosis factor-alpha] production . Regulation TNF MAPK3 10464169 640313 Therefore , both PI 3-K and p38 signaling pathways *control* [TNF-alpha] production in T cells . Regulation TNF MAPK3 10620700 657712 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Regulation TNF MAPK3 10655266 663556 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Regulation TNF MAPK3 10783388 707837 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Regulation TNF MAPK3 11076936 786268 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Regulation TNF MAPK3 11299196 803180 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Regulation TNF MAPK3 11544323 855324 Mycobacteria induced [TNF-alpha] and IL-10 formation by human macrophages is differentially *regulated* at the level of activity . Regulation TNF MAPK3 11675371 873191 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Regulation TNF MAPK3 11675405 873351 It is likely that cAMP-PKA and ( p42/p44 , p38 ) may *play* a critical role in the regulation of the Stx-2 induced [TNF-alpha] transcription via beta(2)-adrenoceptor activation . Regulation TNF MAPK3 11699878 878418 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Regulation TNF MAPK3 11715476 581286 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Regulation TNF MAPK3 11728947 884785 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Regulation TNF MAPK3 11795313 892312 [TNF] *regulates* gene expression in EC , in part , by stimulating which phosphorylate transcription factors . Regulation TNF MAPK3 11815388 907622 These results indicate that the pathway and MAPK mediated *regulation* of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Regulation TNF MAPK3 11833090 910299 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of [TNF-alpha] in spleen , and p38 may be *involved* in its signal transduction mechanisms . Regulation TNF MAPK3 11834148 892990 Regulative *effect* of on release of [TNFalpha] and NO from alveolar macrophages under endotoxin stimulation . Regulation TNF MAPK3 11834148 893004 SB203580 , a specific inhibitor of P38MAPK , was used with gradient concentration to evaluate the regulative *effect* of on the release of [TNFalpha] and NO from AM . Regulation TNF MAPK3 11835717 893012 To study the rule of activity and regulative *effect* of ERK1/2 pathway on the production of pro-inflammatory cytokine [TNFalpha] in mice Kupffer cells ( mKC ) induced by LPS , and to exploring novel methods to prevent and treat clinical patients of endotoxemia . Regulation TNF MAPK3 11997234 939276 However , the *role* of activation in mediating LPS stimulated [TNF-alpha] production is not well understood . Regulation TNF MAPK3 12032367 948085 p38 *plays* a role in postburn cardiomyocyte [tumor necrosis factor-alpha] secretion and cardiac dysfunction . Regulation TNF MAPK3 12506117 1056944 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Regulation TNF MAPK3 12543078 1028745 Together , the p43 induced [TNF] production was *controlled* by NFkB , p38 , and ERK that is dependent on the activities of PLC and PKC . Regulation TNF MAPK3 12704121 1082312 Moreover , using selective inhibitors for MAP kinase kinase ( PD98059 ) and p38 ( SB203580 ) , we show that exhibited differential *effects* on production of [TNF-alpha] and IL-12 p40 by human monocytes , whereas MPL induced activation of p38 appeared to be predominantly involved in production of IL-10 and IL-12 p40 by MPL stimulated monocytes . Regulation TNF MAPK3 12734378 1087365 Our results indicate that A beta induced expression of cytokines ( [TNF-alpha] and IL-1 beta ) and chemokines ( MCP-1 , IL-8 , and MIP-1 beta ) in THP-1 monocytes *involves* activation of and downstream activation of Egr-1 . Regulation TNF MAPK3 12760489 895670 However , a specific inhibitor of p38 , SB203580 , had no *effect* on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Regulation TNF MAPK3 14764603 1235142 Moreover , [TNF-alpha] produced inhibitor kappaB kinase (IKK)-beta activation and inhibitor kappaB-beta and -alpha degradation in a p38 *dependent* manner , and treatment with salicylate ( an inhibitor of IKK ) completely restored insulin signaling . Regulation TNF MAPK3 15557189 1340386 A novel mechanism for [TNF-alpha] *regulation* by p38 : involvement of NF-kappa B with implications for therapy in rheumatoid arthritis . Regulation TNF MAPK3 15557189 1340425 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Regulation TNF MAPK3 15557189 1340451 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Regulation TNF MAPK3 15614136 1357477 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Regulation TNF MAPK3 15650061 1395194 [TNF-alpha] increased PDE2 expression in a p38 *dependent* manner . Regulation TNF MAPK3 15833800 1425453 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Regulation TNF MAPK3 16081599 1460395 These results indicate that gp120 elicited [TNF-alpha] production by macrophages *involves* chemokine receptor mediated PI-3K and activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and ERK-1/2 independently regulate TNF-alpha production . Regulation TNF MAPK3 16231199 1470330 The ( p38-MAPK ) *plays* a key role in lipopolysaccharide induced [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 (IL-1) release during the inflammatory process , emerging as an attractive target for new anti-inflammatory agents . Regulation TNF MAPK3 16480618 1496081 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Regulation TNF MAPK3 16480618 1496120 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Regulation TNF MAPK3 16581537 1543752 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Regulation TNF MAPK3 17074860 1675468 p38 *controls* NF-kappaB transcriptional activation and [tumor necrosis factor] alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation TNF MAPK3 17117477 1677384 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Regulation TNF MAPK3 17138860 1653587 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Regulation TNF MAPK3 17139186 1693716 *Effects* of inhibitors on [tumor necrosis factor-alpha] gene expression and apoptosis induction in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK3 17139186 1693729 We investigated the *involvement* of p38 in [tumor necrosis factor (TNF)-alpha] gene expression , apoptosis induction and virus replication in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK3 17151142 1732357 [TNF-alpha] *regulates* myogenesis and muscle regeneration by activating p38 . Regulation TNF MAPK3 17356569 1821793 Furthermore , pretreatment with IPT prevented rotenone induced mitochondrial membrane potential loss and p38/c-jun N-terminal kinase ( JNK ) activation in microglia , which might in turn *regulate* microglial activation and subsequent production of [TNF-alpha] and PGE ( 2 ) . Regulation TNF MAPK3 17902045 1835090 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Regulation TNF MAPK3 17934341 1813500 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Regulation TNF MAPK3 18314537 1919447 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Regulation TNF MAPK3 18622138 1984387 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Regulation TNF MAPK3 18675993 2011356 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Regulation TNF MAPK3 18841980 1981884 Moreover , we found that extracellular signal regulated kinase 1/2 , Jun N-terminal kinase 1/2 , and p38 *play* important roles in the regulation of [TNFalpha] secretion in ZPF1 stimulated macrophages . Regulation TNF MAPK3 19040616 2017434 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Regulation TNF MAPK3 19250666 2055404 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Regulation TNF MAPK3 19287189 2046620 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Regulation TNF MAPK3 19493203 2091440 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Regulation TNF MAPK3 19666677 2144081 Western blot analysis did not demonstrate the *involvement* of Akt or in [TNF-PostC] , whereas STAT-3 phosphorylation was increased in both IPostC and TNF-PostC . Regulation TNF MAPK3 20068037 2235174 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Regulation TNF MAPK3 20589681 2334378 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Regulation TNF MAPK3 21208554 2374432 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Regulation TNF MAPK3 21208554 2374458 The activation of p38 *plays* an important role in [TNF-a] expression in LPS stimulated cardiomyocytes and the increase of ROS production is prerequisite for the activation of p38 MAPK . Regulation TNF MAPK3 21402598 2426942 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Regulation TNF MAPK3 21819972 2490415 By using selective inhibitors of MAPKs , this study confirms that both activated p38/MK2 pathways and ERK1/2 *play* a significant role in regulation of both [TNF-a] and IL-6 protein production induced by DMXAA at the post-transcriptional level . Regulation TNF MAPK3 22301607 2580357 P38 and *regulate* LPS induced [IL-6/TNF-a] expression through an NF-?B dependent manner and an NF-?B independent manner , respectively . Regulation TNF MAPK3 22767513 2696992 We also observed that in THP-1 and PBMCs , AIMP1 induced [TNF-a] secretion , mediated by CD23 , *involved* activation of . Regulation TNF MAPK3 23557259 2777820 The p38 MAPK activation and [TNF-a] production were *controlled* by p38 and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation TNF MAPK3 24304472 2904831 To determine whether *regulates* c-Fos expression , p38 phosphorylation , NF-?B activation and [TNF-a] production , cardiomyocytes were also treated with U0126 , a selective ERK1/2 inhibitor . Regulation TNF MAPK3 7722327 301811 These results indicate that [TNF] signaling *involves* activation of . Regulation TNF MAPK3 9148963 430066 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Regulation TNF MAPK3 9418855 480544 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Regulation TNF MAPK3 9864164 582658 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Regulation TNF MAPK4 10329111 613044 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Regulation TNF MAPK4 10433212 633960 Intracellular signaling in rat cultured vascular smooth muscle cells : *roles* of nuclear factor-kappaB and p38 on [tumor necrosis factor-alpha] production . Regulation TNF MAPK4 10464169 640314 Therefore , both PI 3-K and p38 signaling pathways *control* [TNF-alpha] production in T cells . Regulation TNF MAPK4 10620700 657713 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Regulation TNF MAPK4 10655266 663557 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Regulation TNF MAPK4 10783388 707838 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Regulation TNF MAPK4 11076936 786269 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Regulation TNF MAPK4 11299196 803181 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Regulation TNF MAPK4 11544323 855325 Mycobacteria induced [TNF-alpha] and IL-10 formation by human macrophages is differentially *regulated* at the level of activity . Regulation TNF MAPK4 11675371 873192 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Regulation TNF MAPK4 11675405 873352 It is likely that cAMP-PKA and ( p42/p44 , p38 ) may *play* a critical role in the regulation of the Stx-2 induced [TNF-alpha] transcription via beta(2)-adrenoceptor activation . Regulation TNF MAPK4 11699878 878419 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Regulation TNF MAPK4 11715476 581287 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Regulation TNF MAPK4 11728947 884786 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Regulation TNF MAPK4 11795313 892313 [TNF] *regulates* gene expression in EC , in part , by stimulating which phosphorylate transcription factors . Regulation TNF MAPK4 11815388 907623 These results indicate that the pathway and MAPK mediated *regulation* of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Regulation TNF MAPK4 11833090 910300 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of [TNF-alpha] in spleen , and p38 may be *involved* in its signal transduction mechanisms . Regulation TNF MAPK4 11834148 892991 Regulative *effect* of on release of [TNFalpha] and NO from alveolar macrophages under endotoxin stimulation . Regulation TNF MAPK4 11834148 893005 SB203580 , a specific inhibitor of P38MAPK , was used with gradient concentration to evaluate the regulative *effect* of on the release of [TNFalpha] and NO from AM . Regulation TNF MAPK4 12032367 948086 p38 *plays* a role in postburn cardiomyocyte [tumor necrosis factor-alpha] secretion and cardiac dysfunction . Regulation TNF MAPK4 12506117 1056945 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Regulation TNF MAPK4 12543078 1028746 Together , the p43 induced [TNF] production was *controlled* by NFkB , p38 , and ERK that is dependent on the activities of PLC and PKC . Regulation TNF MAPK4 12760489 895671 However , a specific inhibitor of p38 , SB203580 , had no *effect* on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Regulation TNF MAPK4 14764603 1235143 Moreover , [TNF-alpha] produced inhibitor kappaB kinase (IKK)-beta activation and inhibitor kappaB-beta and -alpha degradation in a p38 *dependent* manner , and treatment with salicylate ( an inhibitor of IKK ) completely restored insulin signaling . Regulation TNF MAPK4 15557189 1340387 A novel mechanism for [TNF-alpha] *regulation* by p38 : involvement of NF-kappa B with implications for therapy in rheumatoid arthritis . Regulation TNF MAPK4 15557189 1340426 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Regulation TNF MAPK4 15557189 1340452 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Regulation TNF MAPK4 15614136 1357478 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Regulation TNF MAPK4 15650061 1395195 [TNF-alpha] increased PDE2 expression in a p38 *dependent* manner . Regulation TNF MAPK4 15833800 1425454 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Regulation TNF MAPK4 16081599 1460396 These results indicate that gp120 elicited TNF-alpha production by macrophages involves chemokine receptor mediated PI-3K and MAPK activation , that PI-3K is an upstream regulator of in this pathway , and that p38 and ERK-1/2 independently *regulate* [TNF-alpha] production . Regulation TNF MAPK4 16231199 1470331 The ( p38-MAPK ) *plays* a key role in lipopolysaccharide induced [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 (IL-1) release during the inflammatory process , emerging as an attractive target for new anti-inflammatory agents . Regulation TNF MAPK4 16480618 1496082 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Regulation TNF MAPK4 16480618 1496121 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Regulation TNF MAPK4 16581537 1543753 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Regulation TNF MAPK4 17074860 1675469 p38 *controls* NF-kappaB transcriptional activation and [tumor necrosis factor] alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation TNF MAPK4 17117477 1677385 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Regulation TNF MAPK4 17138860 1653588 The purpose of this study was to determine whether the , ERK1/2 , and p38 MAPK are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Regulation TNF MAPK4 17139186 1693717 *Effects* of inhibitors on [tumor necrosis factor-alpha] gene expression and apoptosis induction in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK4 17139186 1693730 We investigated the *involvement* of p38 in [tumor necrosis factor (TNF)-alpha] gene expression , apoptosis induction and virus replication in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK4 17151142 1732358 [TNF-alpha] *regulates* myogenesis and muscle regeneration by activating p38 . Regulation TNF MAPK4 17356569 1821794 Furthermore , pretreatment with IPT prevented rotenone induced mitochondrial membrane potential loss and p38/c-jun N-terminal kinase ( JNK ) activation in microglia , which might in turn *regulate* microglial activation and subsequent production of [TNF-alpha] and PGE ( 2 ) . Regulation TNF MAPK4 17902045 1835091 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Regulation TNF MAPK4 17934341 1813501 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Regulation TNF MAPK4 18314537 1919448 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Regulation TNF MAPK4 18622138 1984388 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Regulation TNF MAPK4 18675993 2011357 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Regulation TNF MAPK4 18841980 1981885 Moreover , we found that extracellular signal regulated kinase 1/2 , Jun N-terminal kinase 1/2 , and p38 *play* important roles in the regulation of [TNFalpha] secretion in ZPF1 stimulated macrophages . Regulation TNF MAPK4 19040616 2017435 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Regulation TNF MAPK4 19250666 2055405 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Regulation TNF MAPK4 19287189 2046621 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Regulation TNF MAPK4 19493203 2091441 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Regulation TNF MAPK4 20068037 2235175 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Regulation TNF MAPK4 20589681 2334379 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Regulation TNF MAPK4 21208554 2374433 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Regulation TNF MAPK4 21208554 2374459 The activation of p38 *plays* an important role in [TNF-a] expression in LPS stimulated cardiomyocytes and the increase of ROS production is prerequisite for the activation of p38 MAPK . Regulation TNF MAPK4 21402598 2426943 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Regulation TNF MAPK4 21819972 2490416 By using selective inhibitors of MAPKs , this study confirms that both activated p38/MK2 pathways and ERK1/2 *play* a significant role in regulation of both [TNF-a] and IL-6 protein production induced by DMXAA at the post-transcriptional level . Regulation TNF MAPK4 23557259 2777821 The p38 MAPK activation and [TNF-a] production were *controlled* by p38 and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation TNF MAPK4 7722327 301812 These results indicate that [TNF] signaling *involves* activation of . Regulation TNF MAPK4 9148963 430067 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Regulation TNF MAPK4 9418855 480545 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Regulation TNF MAPK4 9864164 582659 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Regulation TNF MAPK6 10329111 613045 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Regulation TNF MAPK6 10433212 633961 Intracellular signaling in rat cultured vascular smooth muscle cells : *roles* of nuclear factor-kappaB and p38 on [tumor necrosis factor-alpha] production . Regulation TNF MAPK6 10464169 640315 Therefore , both PI 3-K and p38 signaling pathways *control* [TNF-alpha] production in T cells . Regulation TNF MAPK6 10620700 657714 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Regulation TNF MAPK6 10655266 663558 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Regulation TNF MAPK6 10783388 707839 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Regulation TNF MAPK6 11076936 786270 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Regulation TNF MAPK6 11299196 803182 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Regulation TNF MAPK6 11544323 855326 Mycobacteria induced [TNF-alpha] and IL-10 formation by human macrophages is differentially *regulated* at the level of activity . Regulation TNF MAPK6 11675371 873193 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Regulation TNF MAPK6 11675405 873353 It is likely that cAMP-PKA and ( p42/p44 , p38 ) may *play* a critical role in the regulation of the Stx-2 induced [TNF-alpha] transcription via beta(2)-adrenoceptor activation . Regulation TNF MAPK6 11699878 878420 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Regulation TNF MAPK6 11715476 581288 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Regulation TNF MAPK6 11728947 884787 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Regulation TNF MAPK6 11795313 892314 [TNF] *regulates* gene expression in EC , in part , by stimulating which phosphorylate transcription factors . Regulation TNF MAPK6 11815388 907624 These results indicate that the MAPK pathway and mediated *regulation* of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Regulation TNF MAPK6 11833090 910301 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of [TNF-alpha] in spleen , and p38 may be *involved* in its signal transduction mechanisms . Regulation TNF MAPK6 11834148 892992 Regulative *effect* of on release of [TNFalpha] and NO from alveolar macrophages under endotoxin stimulation . Regulation TNF MAPK6 11834148 893006 SB203580 , a specific inhibitor of P38MAPK , was used with gradient concentration to evaluate the regulative *effect* of on the release of [TNFalpha] and NO from AM . Regulation TNF MAPK6 12032367 948087 p38 *plays* a role in postburn cardiomyocyte [tumor necrosis factor-alpha] secretion and cardiac dysfunction . Regulation TNF MAPK6 12506117 1056946 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Regulation TNF MAPK6 12543078 1028747 Together , the p43 induced [TNF] production was *controlled* by NFkB , p38 , and ERK that is dependent on the activities of PLC and PKC . Regulation TNF MAPK6 12760489 895672 However , a specific inhibitor of p38 , SB203580 , had no *effect* on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Regulation TNF MAPK6 14764603 1235144 Moreover , [TNF-alpha] produced inhibitor kappaB kinase (IKK)-beta activation and inhibitor kappaB-beta and -alpha degradation in a p38 *dependent* manner , and treatment with salicylate ( an inhibitor of IKK ) completely restored insulin signaling . Regulation TNF MAPK6 15557189 1340388 A novel mechanism for [TNF-alpha] *regulation* by p38 : involvement of NF-kappa B with implications for therapy in rheumatoid arthritis . Regulation TNF MAPK6 15557189 1340427 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Regulation TNF MAPK6 15557189 1340453 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Regulation TNF MAPK6 15614136 1357479 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Regulation TNF MAPK6 15650061 1395196 [TNF-alpha] increased PDE2 expression in a p38 *dependent* manner . Regulation TNF MAPK6 15833800 1425455 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Regulation TNF MAPK6 16081599 1460397 These results indicate that gp120 elicited [TNF-alpha] production by macrophages *involves* chemokine receptor mediated PI-3K and activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and ERK-1/2 independently regulate TNF-alpha production . Regulation TNF MAPK6 16231199 1470332 The ( p38-MAPK ) *plays* a key role in lipopolysaccharide induced [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 (IL-1) release during the inflammatory process , emerging as an attractive target for new anti-inflammatory agents . Regulation TNF MAPK6 16480618 1496083 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Regulation TNF MAPK6 16480618 1496122 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Regulation TNF MAPK6 16581537 1543754 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Regulation TNF MAPK6 17074860 1675470 p38 *controls* NF-kappaB transcriptional activation and [tumor necrosis factor] alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation TNF MAPK6 17117477 1677386 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Regulation TNF MAPK6 17138860 1653589 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Regulation TNF MAPK6 17139186 1693718 *Effects* of inhibitors on [tumor necrosis factor-alpha] gene expression and apoptosis induction in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK6 17139186 1693731 We investigated the *involvement* of p38 in [tumor necrosis factor (TNF)-alpha] gene expression , apoptosis induction and virus replication in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK6 17151142 1732359 [TNF-alpha] *regulates* myogenesis and muscle regeneration by activating p38 . Regulation TNF MAPK6 17356569 1821795 Furthermore , pretreatment with IPT prevented rotenone induced mitochondrial membrane potential loss and p38/c-jun N-terminal kinase ( JNK ) activation in microglia , which might in turn *regulate* microglial activation and subsequent production of [TNF-alpha] and PGE ( 2 ) . Regulation TNF MAPK6 17902045 1835092 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Regulation TNF MAPK6 17934341 1813502 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Regulation TNF MAPK6 18314537 1919449 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Regulation TNF MAPK6 18622138 1984389 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Regulation TNF MAPK6 18675993 2011358 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Regulation TNF MAPK6 18841980 1981886 Moreover , we found that extracellular signal regulated kinase 1/2 , Jun N-terminal kinase 1/2 , and p38 *play* important roles in the regulation of [TNFalpha] secretion in ZPF1 stimulated macrophages . Regulation TNF MAPK6 19040616 2017436 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Regulation TNF MAPK6 19250666 2055406 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Regulation TNF MAPK6 19287189 2046622 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Regulation TNF MAPK6 19493203 2091442 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Regulation TNF MAPK6 20068037 2235176 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Regulation TNF MAPK6 20589681 2334380 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Regulation TNF MAPK6 21208554 2374434 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Regulation TNF MAPK6 21208554 2374460 The activation of p38 *plays* an important role in [TNF-a] expression in LPS stimulated cardiomyocytes and the increase of ROS production is prerequisite for the activation of p38 MAPK . Regulation TNF MAPK6 21402598 2426944 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Regulation TNF MAPK6 21819972 2490417 By using selective inhibitors of MAPKs , this study confirms that both activated p38/MK2 pathways and ERK1/2 *play* a significant role in regulation of both [TNF-a] and IL-6 protein production induced by DMXAA at the post-transcriptional level . Regulation TNF MAPK6 23557259 2777822 The p38 MAPK activation and [TNF-a] production were *controlled* by p38 and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation TNF MAPK6 7722327 301813 These results indicate that [TNF] signaling *involves* activation of . Regulation TNF MAPK6 9148963 430068 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Regulation TNF MAPK6 9418855 480546 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Regulation TNF MAPK6 9864164 582660 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Regulation TNF MAPK7 10329111 613046 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Regulation TNF MAPK7 10433212 633962 Intracellular signaling in rat cultured vascular smooth muscle cells : *roles* of nuclear factor-kappaB and p38 on [tumor necrosis factor-alpha] production . Regulation TNF MAPK7 10464169 640316 Therefore , both PI 3-K and p38 signaling pathways *control* [TNF-alpha] production in T cells . Regulation TNF MAPK7 10620700 657715 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Regulation TNF MAPK7 10655266 663559 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Regulation TNF MAPK7 10783388 707840 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Regulation TNF MAPK7 11076936 786271 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Regulation TNF MAPK7 11299196 803183 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Regulation TNF MAPK7 11544323 855327 Mycobacteria induced [TNF-alpha] and IL-10 formation by human macrophages is differentially *regulated* at the level of activity . Regulation TNF MAPK7 11675371 873194 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Regulation TNF MAPK7 11675405 873354 It is likely that cAMP-PKA and ( p42/p44 , p38 ) may *play* a critical role in the regulation of the Stx-2 induced [TNF-alpha] transcription via beta(2)-adrenoceptor activation . Regulation TNF MAPK7 11699878 878421 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Regulation TNF MAPK7 11715476 581289 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Regulation TNF MAPK7 11728947 884788 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Regulation TNF MAPK7 11795313 892315 [TNF] *regulates* gene expression in EC , in part , by stimulating which phosphorylate transcription factors . Regulation TNF MAPK7 11815388 907625 These results indicate that the pathway and MAPK mediated *regulation* of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Regulation TNF MAPK7 11833090 910302 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of [TNF-alpha] in spleen , and p38 may be *involved* in its signal transduction mechanisms . Regulation TNF MAPK7 11834148 892993 Regulative *effect* of on release of [TNFalpha] and NO from alveolar macrophages under endotoxin stimulation . Regulation TNF MAPK7 11834148 893007 SB203580 , a specific inhibitor of P38MAPK , was used with gradient concentration to evaluate the regulative *effect* of on the release of [TNFalpha] and NO from AM . Regulation TNF MAPK7 12032367 948088 p38 *plays* a role in postburn cardiomyocyte [tumor necrosis factor-alpha] secretion and cardiac dysfunction . Regulation TNF MAPK7 12506117 1056947 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Regulation TNF MAPK7 12543078 1028748 Together , the p43 induced [TNF] production was *controlled* by NFkB , p38 , and ERK that is dependent on the activities of PLC and PKC . Regulation TNF MAPK7 12760489 895673 However , a specific inhibitor of p38 , SB203580 , had no *effect* on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Regulation TNF MAPK7 14764603 1235145 Moreover , [TNF-alpha] produced inhibitor kappaB kinase (IKK)-beta activation and inhibitor kappaB-beta and -alpha degradation in a p38 *dependent* manner , and treatment with salicylate ( an inhibitor of IKK ) completely restored insulin signaling . Regulation TNF MAPK7 15557189 1340389 A novel mechanism for [TNF-alpha] *regulation* by p38 : involvement of NF-kappa B with implications for therapy in rheumatoid arthritis . Regulation TNF MAPK7 15557189 1340428 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Regulation TNF MAPK7 15557189 1340454 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Regulation TNF MAPK7 15614136 1357480 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Regulation TNF MAPK7 15650061 1395197 [TNF-alpha] increased PDE2 expression in a p38 *dependent* manner . Regulation TNF MAPK7 15833800 1425456 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Regulation TNF MAPK7 16081599 1460398 These results indicate that gp120 elicited TNF-alpha production by macrophages involves chemokine receptor mediated PI-3K and MAPK activation , that PI-3K is an upstream regulator of in this pathway , and that p38 and ERK-1/2 independently *regulate* [TNF-alpha] production . Regulation TNF MAPK7 16231199 1470333 The ( p38-MAPK ) *plays* a key role in lipopolysaccharide induced [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 (IL-1) release during the inflammatory process , emerging as an attractive target for new anti-inflammatory agents . Regulation TNF MAPK7 16480618 1496084 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Regulation TNF MAPK7 16480618 1496123 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Regulation TNF MAPK7 16581537 1543755 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Regulation TNF MAPK7 17074860 1675471 p38 *controls* NF-kappaB transcriptional activation and [tumor necrosis factor] alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation TNF MAPK7 17117477 1677387 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Regulation TNF MAPK7 17138860 1653590 The purpose of this study was to determine whether the , ERK1/2 , and p38 MAPK are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Regulation TNF MAPK7 17139186 1693719 *Effects* of inhibitors on [tumor necrosis factor-alpha] gene expression and apoptosis induction in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK7 17139186 1693732 We investigated the *involvement* of p38 in [tumor necrosis factor (TNF)-alpha] gene expression , apoptosis induction and virus replication in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK7 17151142 1732360 [TNF-alpha] *regulates* myogenesis and muscle regeneration by activating p38 . Regulation TNF MAPK7 17356569 1821796 Furthermore , pretreatment with IPT prevented rotenone induced mitochondrial membrane potential loss and p38/c-jun N-terminal kinase ( JNK ) activation in microglia , which might in turn *regulate* microglial activation and subsequent production of [TNF-alpha] and PGE ( 2 ) . Regulation TNF MAPK7 17902045 1835093 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Regulation TNF MAPK7 17934341 1813503 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Regulation TNF MAPK7 18314537 1919450 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Regulation TNF MAPK7 18622138 1984390 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Regulation TNF MAPK7 18675993 2011359 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Regulation TNF MAPK7 18841980 1981887 Moreover , we found that extracellular signal regulated kinase 1/2 , Jun N-terminal kinase 1/2 , and p38 *play* important roles in the regulation of [TNFalpha] secretion in ZPF1 stimulated macrophages . Regulation TNF MAPK7 19040616 2017437 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Regulation TNF MAPK7 19250666 2055407 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Regulation TNF MAPK7 19287189 2046623 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Regulation TNF MAPK7 19493203 2091443 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Regulation TNF MAPK7 20068037 2235177 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Regulation TNF MAPK7 20589681 2334381 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Regulation TNF MAPK7 21208554 2374435 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Regulation TNF MAPK7 21208554 2374461 The activation of p38 *plays* an important role in [TNF-a] expression in LPS stimulated cardiomyocytes and the increase of ROS production is prerequisite for the activation of p38 MAPK . Regulation TNF MAPK7 21402598 2426945 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Regulation TNF MAPK7 21819972 2490418 By using selective inhibitors of MAPKs , this study confirms that both activated p38/MK2 pathways and ERK1/2 *play* a significant role in regulation of both [TNF-a] and IL-6 protein production induced by DMXAA at the post-transcriptional level . Regulation TNF MAPK7 23557259 2777823 The p38 MAPK activation and [TNF-a] production were *controlled* by p38 and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation TNF MAPK7 7722327 301814 These results indicate that [TNF] signaling *involves* activation of . Regulation TNF MAPK7 9148963 430069 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Regulation TNF MAPK7 9418855 480547 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Regulation TNF MAPK7 9864164 582661 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Regulation TNF MAPK8 10329111 613047 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Regulation TNF MAPK8 10433212 633963 Intracellular signaling in rat cultured vascular smooth muscle cells : *roles* of nuclear factor-kappaB and p38 on [tumor necrosis factor-alpha] production . Regulation TNF MAPK8 10464169 640317 Therefore , both PI 3-K and p38 signaling pathways *control* [TNF-alpha] production in T cells . Regulation TNF MAPK8 10620700 657716 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Regulation TNF MAPK8 10655266 663560 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Regulation TNF MAPK8 10783388 707841 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Regulation TNF MAPK8 11076936 786272 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Regulation TNF MAPK8 11299196 803184 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Regulation TNF MAPK8 11544323 855328 Mycobacteria induced [TNF-alpha] and IL-10 formation by human macrophages is differentially *regulated* at the level of activity . Regulation TNF MAPK8 11675371 873195 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Regulation TNF MAPK8 11675405 873355 It is likely that cAMP-PKA and ( p42/p44 , p38 ) may *play* a critical role in the regulation of the Stx-2 induced [TNF-alpha] transcription via beta(2)-adrenoceptor activation . Regulation TNF MAPK8 11699878 878422 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Regulation TNF MAPK8 11715476 581290 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Regulation TNF MAPK8 11728947 884789 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Regulation TNF MAPK8 11795313 892316 [TNF] *regulates* gene expression in EC , in part , by stimulating which phosphorylate transcription factors . Regulation TNF MAPK8 11815388 907626 These results indicate that the MAPK pathway and mediated *regulation* of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Regulation TNF MAPK8 11833090 910303 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of [TNF-alpha] in spleen , and p38 may be *involved* in its signal transduction mechanisms . Regulation TNF MAPK8 11834148 892994 Regulative *effect* of on release of [TNFalpha] and NO from alveolar macrophages under endotoxin stimulation . Regulation TNF MAPK8 11834148 893008 SB203580 , a specific inhibitor of P38MAPK , was used with gradient concentration to evaluate the regulative *effect* of on the release of [TNFalpha] and NO from AM . Regulation TNF MAPK8 12032367 948089 p38 *plays* a role in postburn cardiomyocyte [tumor necrosis factor-alpha] secretion and cardiac dysfunction . Regulation TNF MAPK8 12506117 1056948 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Regulation TNF MAPK8 12543078 1028749 Together , the p43 induced [TNF] production was *controlled* by NFkB , p38 , and ERK that is dependent on the activities of PLC and PKC . Regulation TNF MAPK8 12760489 895674 However , a specific inhibitor of p38 , SB203580 , had no *effect* on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Regulation TNF MAPK8 14764603 1235146 Moreover , [TNF-alpha] produced inhibitor kappaB kinase (IKK)-beta activation and inhibitor kappaB-beta and -alpha degradation in a p38 *dependent* manner , and treatment with salicylate ( an inhibitor of IKK ) completely restored insulin signaling . Regulation TNF MAPK8 15557189 1340390 A novel mechanism for [TNF-alpha] *regulation* by p38 : involvement of NF-kappa B with implications for therapy in rheumatoid arthritis . Regulation TNF MAPK8 15557189 1340429 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Regulation TNF MAPK8 15557189 1340455 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Regulation TNF MAPK8 15614136 1357481 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Regulation TNF MAPK8 15650061 1395198 [TNF-alpha] increased PDE2 expression in a p38 *dependent* manner . Regulation TNF MAPK8 15833800 1425457 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Regulation TNF MAPK8 16081599 1460399 These results indicate that gp120 elicited [TNF-alpha] production by macrophages *involves* chemokine receptor mediated PI-3K and activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and ERK-1/2 independently regulate TNF-alpha production . Regulation TNF MAPK8 16231199 1470334 The ( p38-MAPK ) *plays* a key role in lipopolysaccharide induced [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 (IL-1) release during the inflammatory process , emerging as an attractive target for new anti-inflammatory agents . Regulation TNF MAPK8 16480618 1496085 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Regulation TNF MAPK8 16480618 1496124 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Regulation TNF MAPK8 16581537 1543756 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Regulation TNF MAPK8 17074860 1675472 p38 *controls* NF-kappaB transcriptional activation and [tumor necrosis factor] alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation TNF MAPK8 17117477 1677388 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Regulation TNF MAPK8 17138860 1653591 The purpose of this study was to determine whether the MAPK , ERK1/2 , and p38 are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Regulation TNF MAPK8 17139186 1693720 *Effects* of inhibitors on [tumor necrosis factor-alpha] gene expression and apoptosis induction in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK8 17139186 1693733 We investigated the *involvement* of p38 in [tumor necrosis factor (TNF)-alpha] gene expression , apoptosis induction and virus replication in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK8 17151142 1732361 [TNF-alpha] *regulates* myogenesis and muscle regeneration by activating p38 . Regulation TNF MAPK8 17356569 1821797 Furthermore , pretreatment with IPT prevented rotenone induced mitochondrial membrane potential loss and p38/c-jun N-terminal kinase ( JNK ) activation in microglia , which might in turn *regulate* microglial activation and subsequent production of [TNF-alpha] and PGE ( 2 ) . Regulation TNF MAPK8 17902045 1835094 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Regulation TNF MAPK8 17934341 1813504 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Regulation TNF MAPK8 18314537 1919451 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Regulation TNF MAPK8 18622138 1984391 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Regulation TNF MAPK8 18675993 2011360 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Regulation TNF MAPK8 18841980 1981888 Moreover , we found that extracellular signal regulated kinase 1/2 , Jun N-terminal kinase 1/2 , and p38 *play* important roles in the regulation of [TNFalpha] secretion in ZPF1 stimulated macrophages . Regulation TNF MAPK8 19040616 2017438 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Regulation TNF MAPK8 19250666 2055408 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Regulation TNF MAPK8 19287189 2046624 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Regulation TNF MAPK8 19493203 2091444 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Regulation TNF MAPK8 20068037 2235178 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Regulation TNF MAPK8 20589681 2334382 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Regulation TNF MAPK8 21208554 2374436 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Regulation TNF MAPK8 21208554 2374462 The activation of p38 *plays* an important role in [TNF-a] expression in LPS stimulated cardiomyocytes and the increase of ROS production is prerequisite for the activation of p38 MAPK . Regulation TNF MAPK8 21402598 2426946 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Regulation TNF MAPK8 21819972 2490419 By using selective inhibitors of MAPKs , this study confirms that both activated p38/MK2 pathways and ERK1/2 *play* a significant role in regulation of both [TNF-a] and IL-6 protein production induced by DMXAA at the post-transcriptional level . Regulation TNF MAPK8 23557259 2777824 The p38 MAPK activation and [TNF-a] production were *controlled* by p38 and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation TNF MAPK8 7722327 301815 These results indicate that [TNF] signaling *involves* activation of . Regulation TNF MAPK8 9148963 430070 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Regulation TNF MAPK8 9418855 480548 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Regulation TNF MAPK8 9864164 582662 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Regulation TNF MAPK9 10329111 613048 Macrophage [TNF] secretion in endotoxin tolerance : *role* of SAPK , p38 , and . Regulation TNF MAPK9 10433212 633964 Intracellular signaling in rat cultured vascular smooth muscle cells : *roles* of nuclear factor-kappaB and p38 on [tumor necrosis factor-alpha] production . Regulation TNF MAPK9 10464169 640318 Therefore , both PI 3-K and p38 signaling pathways *control* [TNF-alpha] production in T cells . Regulation TNF MAPK9 10620700 657717 We examined the *role* of p38 in the [tumor necrosis factor alpha (TNF-alpha)-] or interleukin-1beta (IL-1beta) induced production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in fresh rheumatoid synovial fibroblast ( RSF ) cultures concomitantly with the induction of p38 MAP kinase activity . Regulation TNF MAPK9 10655266 663561 The *role* of protein kinase B and in epidermal growth factor and [tumor necrosis factor] alpha mediated rat hepatocyte survival and apoptosis . Regulation TNF MAPK9 10783388 707842 To elucidate mechanisms of tumor necrosis factor alpha (TNF-alpha) induced proliferation of a number of human leukemia and lymphoma cell lines , we examined the *role* of p38 in [TNF-alpha] signaling in Mo7e and Hut-78 cells . Regulation TNF MAPK9 11076936 786273 We have studied the *role* of ERK and p38 in controlling [TNF-alpha] mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes . Regulation TNF MAPK9 11299196 803185 *Role* of p38 in cardiac myocyte secretion of the inflammatory cytokine [TNF-alpha] . Regulation TNF MAPK9 11544323 855329 Mycobacteria induced [TNF-alpha] and IL-10 formation by human macrophages is differentially *regulated* at the level of activity . Regulation TNF MAPK9 11675371 873196 Like NF-kappaB activation , CpG DNA induced activation of *regulates* [TNF-alpha] production . Regulation TNF MAPK9 11675405 873356 It is likely that cAMP-PKA and ( p42/p44 , p38 ) may *play* a critical role in the regulation of the Stx-2 induced [TNF-alpha] transcription via beta(2)-adrenoceptor activation . Regulation TNF MAPK9 11699878 878423 The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the *role* of extracellular signal regulated kinase ( ERK ) and p38 in the mucosal release of [tumor necrosis factor-alpha (TNF-alpha)] and endothelin-1 (ET-1) in response to H. pylori infection . Regulation TNF MAPK9 11715476 581291 [ The *role* of activation of p38 induced by LPS in [TNF-alpha] gene expression ] . Regulation TNF MAPK9 11728947 884790 p38 is *involved* in the production and signal transduction of interleukin-1beta (IL-1beta) , [tumor necrosis factor-alpha] , and chemokines in vitro . Regulation TNF MAPK9 11795313 892317 [TNF] *regulates* gene expression in EC , in part , by stimulating which phosphorylate transcription factors . Regulation TNF MAPK9 11815388 907627 These results indicate that the MAPK pathway and mediated *regulation* of [TNF-alpha] production is redox dependent , GSH mediated and requires , at least in part , a NF-kappaB/ROS-sensitive mechanism . Regulation TNF MAPK9 11833090 910304 CCK-8 reverses the decrease of MAP in ES rats and has inhibitory effect on the gene and protein expression of [TNF-alpha] in spleen , and p38 may be *involved* in its signal transduction mechanisms . Regulation TNF MAPK9 11834148 892995 Regulative *effect* of on release of [TNFalpha] and NO from alveolar macrophages under endotoxin stimulation . Regulation TNF MAPK9 11834148 893009 SB203580 , a specific inhibitor of P38MAPK , was used with gradient concentration to evaluate the regulative *effect* of on the release of [TNFalpha] and NO from AM . Regulation TNF MAPK9 12032367 948090 p38 *plays* a role in postburn cardiomyocyte [tumor necrosis factor-alpha] secretion and cardiac dysfunction . Regulation TNF MAPK9 12506117 1056949 The purpose of this study was to investigate the *role* of endothelial nitric-oxide synthase (eNOS) , cAMP , and p38 in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Regulation TNF MAPK9 12543078 1028750 Together , the p43 induced [TNF] production was *controlled* by NFkB , p38 , and ERK that is dependent on the activities of PLC and PKC . Regulation TNF MAPK9 12760489 895675 However , a specific inhibitor of p38 , SB203580 , had no *effect* on [TNF-alpha/IFN-gamma] or LPS/IFN-gamma induced NF-kappaB activation . Regulation TNF MAPK9 14764603 1235147 Moreover , [TNF-alpha] produced inhibitor kappaB kinase (IKK)-beta activation and inhibitor kappaB-beta and -alpha degradation in a p38 *dependent* manner , and treatment with salicylate ( an inhibitor of IKK ) completely restored insulin signaling . Regulation TNF MAPK9 15557189 1340391 A novel mechanism for [TNF-alpha] *regulation* by p38 : involvement of NF-kappa B with implications for therapy in rheumatoid arthritis . Regulation TNF MAPK9 15557189 1340430 This study examines the *role* of p38 in the regulation of [TNF-alpha] in primary human cells relevant to inflammation , e.g. , macrophages and rheumatoid synovial cells . Regulation TNF MAPK9 15557189 1340456 Using a dominant negative variant ( D168A ) of p38 MAPK and a kinase inhibitor , SB203580 , we confirm in primary human macrophages that p38 *regulates* [TNF-alpha] production using a posttranscriptional mechanism requiring the 3 ' untranslated region of the gene . Regulation TNF MAPK9 15614136 1357482 LPS induced expression of [TNF-alpha] is partly *regulated* by the p38 , which post-transcriptionally stabilizes TNF-alpha mRNA . Regulation TNF MAPK9 15650061 1395199 [TNF-alpha] increased PDE2 expression in a p38 *dependent* manner . Regulation TNF MAPK9 15833800 1425458 Inhibitor studies in endothelial cells demonstrated a critical *role* for PKC in mediating thrombin , [TNF-alpha] , and LPS induction of ICAM-1 , TF , and u-PA and for p38 in mediating thrombin , TNF-alpha , and LPS induction of TF . Regulation TNF MAPK9 16081599 1460400 These results indicate that gp120 elicited TNF-alpha production by macrophages involves chemokine receptor mediated PI-3K and MAPK activation , that PI-3K is an upstream regulator of in this pathway , and that p38 and ERK-1/2 independently *regulate* [TNF-alpha] production . Regulation TNF MAPK9 16231199 1470335 The ( p38-MAPK ) *plays* a key role in lipopolysaccharide induced [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 (IL-1) release during the inflammatory process , emerging as an attractive target for new anti-inflammatory agents . Regulation TNF MAPK9 16480618 1496086 [ The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats ] . Regulation TNF MAPK9 16480618 1496125 To investigate The modulating *role* of p38 in the expression of [tumor necrosis factor-alpha] in hepatic cells and its role in hepatic injury in severely burned rats . Regulation TNF MAPK9 16581537 1543757 We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury , and the *roles* of protein kinase C ( PKC ) and p42/44 in the induction of [TNF-alpha] . Regulation TNF MAPK9 17074860 1675473 p38 *controls* NF-kappaB transcriptional activation and [tumor necrosis factor] alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens . Regulation TNF MAPK9 17117477 1677389 In contrast , [TNF-alpha] and IL-6 production was differentially *regulated* by depending on the TLR pathway stimulated . Regulation TNF MAPK9 17138860 1653592 The purpose of this study was to determine whether the , ERK1/2 , and p38 MAPK are *involved* in [TNF] antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF . Regulation TNF MAPK9 17139186 1693721 *Effects* of inhibitors on [tumor necrosis factor-alpha] gene expression and apoptosis induction in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK9 17139186 1693734 We investigated the *involvement* of p38 in [tumor necrosis factor (TNF)-alpha] gene expression , apoptosis induction and virus replication in cultured human fetal membrane chorion cells infected with influenza virus . Regulation TNF MAPK9 17151142 1732362 [TNF-alpha] *regulates* myogenesis and muscle regeneration by activating p38 . Regulation TNF MAPK9 17356569 1821798 Furthermore , pretreatment with IPT prevented rotenone induced mitochondrial membrane potential loss and p38/c-jun N-terminal kinase ( JNK ) activation in microglia , which might in turn *regulate* microglial activation and subsequent production of [TNF-alpha] and PGE ( 2 ) . Regulation TNF MAPK9 17902045 1835095 Induction of [TNF-alpha] by LPS in Schwann cell is *regulated* by activation signals . Regulation TNF MAPK9 17934341 1813505 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not c-Src , JNK , nor p38 . Regulation TNF MAPK9 18314537 1919452 We have demonstrated that the p38 *regulates* [TNF-alpha] expression in monocytes exposed to asbestos . Regulation TNF MAPK9 18622138 1984392 [TNF-alpha-induces] cPLA(2) activation through the pathway *involving* p38 and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis . Regulation TNF MAPK9 18675993 2011361 In this study , we set out to examine the precise *role* of both protein kinase C ( PKC ) and P38 signaling kinases in bacterial lipoprotein (BLP) induced nuclear factor-kappa B (NFkappaB) activation and [tumor necrosis factor-alpha (TNFalpha)] release in THP-1 monocytic cell line . Regulation TNF MAPK9 18841980 1981889 Moreover , we found that extracellular signal regulated kinase 1/2 , Jun N-terminal kinase 1/2 , and p38 *play* important roles in the regulation of [TNFalpha] secretion in ZPF1 stimulated macrophages . Regulation TNF MAPK9 19040616 2017439 At the same time , p38 was *involved* in [TNF-alpha] and IFN-gamma induced TN-C transcription . Regulation TNF MAPK9 19250666 2055409 When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of P38 mitogen activated protein kinase (MAPK) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM ) resulted in a P38 *dependent* increase in secretion of [TNF-alpha] . Regulation TNF MAPK9 19287189 2046625 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Regulation TNF MAPK9 19493203 2091445 Here the *role* of in [TNF-alpha] production in macrophages after infection with O. tsutsugamushi has been investigated . Regulation TNF MAPK9 20068037 2235179 Nef inhibits ASK1/p38 *dependent* Mtb induced [TNF-alpha] production probably by inhibiting binding of ATF2 to the TNF-alpha promoter . Regulation TNF MAPK9 20589681 2334383 The activity of p38 *regulates* lipopolysaccharide (LPS) stimulated production of key proinflammatory cytokines such as [tumor necrosis factor a (TNFa)] . Regulation TNF MAPK9 21208554 2374437 To investigate the *role* of p38 ( MAPK ) in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression in neonatal rat cardiomyocytes and to determine the relationship between reactive oxygen species ( ROS ) and p38 MAPK activation . Regulation TNF MAPK9 21208554 2374463 The activation of p38 *plays* an important role in [TNF-a] expression in LPS stimulated cardiomyocytes and the increase of ROS production is prerequisite for the activation of p38 MAPK . Regulation TNF MAPK9 21402598 2426947 In addition , transcription of grouper immune genes including interferon regulatory factor 1 , interleukin-8 and tumour necrosis factor alpha ( TNF-a ) were regulated by JNK , whilst only [TNF-a] was *regulated* by p38 . Regulation TNF MAPK9 21819972 2490420 By using selective inhibitors of MAPKs , this study confirms that both activated p38/MK2 pathways and ERK1/2 *play* a significant role in regulation of both [TNF-a] and IL-6 protein production induced by DMXAA at the post-transcriptional level . Regulation TNF MAPK9 23557259 2777825 The p38 MAPK activation and [TNF-a] production were *controlled* by p38 and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation TNF MAPK9 7722327 301816 These results indicate that [TNF] signaling *involves* activation of . Regulation TNF MAPK9 9148963 430071 *regulates* production of [tumor necrosis factor-alpha] and release of arachidonic acid in mast cells . Regulation TNF MAPK9 9418855 480549 These findings provide evidence for a *role* of NaSal induced p38 activation in the inhibition of [TNF] signaling and suggest a possible role for the p38 MAPK in the anti-inflammatory actions of salicylates . Regulation TNF MAPK9 9864164 582663 In addition , because SB203580 had no effect of TNF- or ceramide induced apoptosis , our results strongly argue against a *role* for p38 in the induction of [TNF] -- or ceramide induced apoptosis . Regulation TNF MAPKAPK2 16620770 1556716 ( MAPKAPK2 ) *regulates* the synthesis of [tumor necrosis factor] and other cytokines and is a potential drug target for inflammatory diseases . Regulation TNF MAPKAPK2 17485113 1744269 Distinct *role* of in the regulation of [TNF] gene expression by Toll-like receptor 7 and 9 ligands . Regulation TNF MAPKAPK2 19359247 2081243 In this study , we investigated the *role* of in the regulation of [tumor necrosis factor-alpha (TNF-alpha)] and interleukin (IL)-12 , two of the major inflammatory cytokines produced by macrophages stimulated with GPIs . Regulation TNF MAPKAPK2 19359247 2081252 We show that differentially *regulates* the GPI induced production of [TNF-alpha] and IL-12 . Regulation TNF MAPKAPK2 24046015 2857398 and ( 3 ) although [TNF-a] overexpression in FA cells is *controlled* posttranscriptionally by the p38 substrate , p38 dependent overproduction of IL-1ß is controlled transcriptionally . Regulation TNF MAST1 9352858 461277 cell *dependent* [tumor necrosis factor] alpha production participates in allergic gastric inflammation in mice . Regulation TNF MAST2 14764729 1207392 Similarly , dominant negative mutants inhibit LPS stimulated IL-12 synthesis and NF-kappaB activation , but do not *affect* IL-1 or [TNF-alpha] signaling . Regulation TNF MAST2 9352858 461278 cell *dependent* [tumor necrosis factor] alpha production participates in allergic gastric inflammation in mice . Regulation TNF MAST3 9352858 461279 cell *dependent* [tumor necrosis factor] alpha production participates in allergic gastric inflammation in mice . Regulation TNF MAST4 9352858 461280 cell *dependent* [tumor necrosis factor] alpha production participates in allergic gastric inflammation in mice . Regulation TNF MBL2 18070904 1868047 Little is known about the *effects* of serum factors or on the interaction of Blastomyces dermatitidis , a pulmonary fungal pathogen , with macrophages or on [tumor necrosis factor alpha (TNF-alpha)] production . Regulation TNF MBL2 21355310 2394611 To investigate the *effect* of high glucose and complement pathway activation 's effect on expression of Interleukin-6 (IL-6) and [Tumor necrosis factor-alpha (TNF-alpha)] from human renal glomerular endothelial cells ( HRGEC ) , to explore unknown pathogenesy of diabetic nephropathy . Regulation TNF MBP 7544384 318279 Mechanisms by which IFN-tau may prevent EAE include reduced proliferation in *response* to the autoantigen and reduced [TNF-alpha] production . Regulation TNF MBP 8872905 389717 Stimulation of cells from MBP73-84 : 1028 coimmunized protected rats proliferate and secrete interferon-gamma (IFN-gamma) and [tumor necrosis factor-alpha (TNF-alpha)] in vitro in *response* to . Regulation TNF MBTPS1 16508938 1530317 We investigated the effects of on proliferation by WST-1 assay , and its *effects* on [tumor necrosis factor alpha (TNFalpha)-] or interleukin-1beta (IL-1beta) induced cyclooxygenase 2 (COX-2) expression and prostaglandin E2 ( PGE2 ) production in RA synoviocytes and MH7A cells by Western blotting and enzyme linked immunosorbent assay , respectively . Regulation TNF MBTPS1 18294150 1873088 Downregulating ( 1R ) did not *affect* production of interleukin (IL)-10and [tumor necrosis factor (TNF)-alpha] , or expression of adhesion molecules critical for migration , but prevented rejection pathology and lowered local levels of IFN-gamma post adoptive transfer . Regulation TNF MBTPS1 20577214 2280428 These results also highlight the key *role* of SphK1 and its product in [TNF-alpha] signalling and the canonical NF-kappaB activation pathway important in inflammatory , antiapoptotic and immune processes . Regulation TNF MBTPS1 20624458 2304154 Although our experimental data clearly show the mediatory *role* of sphingosine kinase (SK) derived in the [TNF-alpha] and the LPS induced activation of NF-kB , exogenously added S1P failed to trigger this transcription factor . Regulation TNF MBTPS1 21805322 2524140 Recent studies have also revealed the *involvement* of signaling in coagulation and in [tumor necrosis factor] a-mediated signaling . Regulation TNF MC1R 12895657 1118046 *Regulation* of [TNF-alpha] secretion by a specific peptide agonist . Regulation TNF MCC 11746260 889070 The synthesis of IL-12 , GM-CSF , and [TNF-alpha] by LNCaP cells in *response* to was also determined . Regulation TNF MDM1 17302905 1698997 Because dendritic cells (DCs) orchestrate immune responses , we examined the in vitro *effects* of clarithromycin (CAM) , azithromycin ( AZM ) and on the expression of co-stimulatory molecules and production of cytokines [interleukin (IL)-10 , IL-6 , interferon (IFN)-gamma , IL-12p40 , [tumour necrosis factor (TNF)-alpha] ] of murine bone marrow derived DCs by lipopolysaccharide (LPS) stimulation . Regulation TNF MDM2 17302905 1698998 Because dendritic cells (DCs) orchestrate immune responses , we examined the in vitro *effects* of clarithromycin (CAM) , azithromycin ( AZM ) and on the expression of co-stimulatory molecules and production of cytokines [interleukin (IL)-10 , IL-6 , interferon (IFN)-gamma , IL-12p40 , [tumour necrosis factor (TNF)-alpha] ] of murine bone marrow derived DCs by lipopolysaccharide (LPS) stimulation . Regulation TNF MDM4 17302905 1698999 Because dendritic cells (DCs) orchestrate immune responses , we examined the in vitro *effects* of clarithromycin (CAM) , azithromycin ( AZM ) and on the expression of co-stimulatory molecules and production of cytokines [interleukin (IL)-10 , IL-6 , interferon (IFN)-gamma , IL-12p40 , [tumour necrosis factor (TNF)-alpha] ] of murine bone marrow derived DCs by lipopolysaccharide (LPS) stimulation . Regulation TNF MED1 12947019 1151674 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED1 16945012 1609921 Compound 1 did not affect the [tumor necrosis factor-alpha-] or lipopolysaccharide induced *response* , suggesting selective inhibition of the RANKL induced pathway . Regulation TNF MED10 12947019 1151669 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED11 12947019 1151672 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED12 12947019 1151644 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED12 16945012 1609915 Compound 1 did not affect the [tumor necrosis factor-alpha-] or lipopolysaccharide induced *response* , suggesting selective inhibition of the RANKL induced pathway . Regulation TNF MED13 12947019 1151654 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED13L 12947019 1151655 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED14 12947019 1151659 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED14 16945012 1609919 Compound 1 did not affect the [tumor necrosis factor-alpha-] or lipopolysaccharide induced *response* , suggesting selective inhibition of the RANKL induced pathway . Regulation TNF MED15 12947019 1151645 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED16 12947019 1151648 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED16 16945012 1609916 Compound 1 did not affect the [tumor necrosis factor-alpha-] or lipopolysaccharide induced *response* , suggesting selective inhibition of the RANKL induced pathway . Regulation TNF MED17 12947019 1151661 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED17 16945012 1609920 Compound 1 did not affect the [tumor necrosis factor-alpha-] or lipopolysaccharide induced *response* , suggesting selective inhibition of the RANKL induced pathway . Regulation TNF MED18 12947019 1151668 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED19 12947019 1151671 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED20 12947019 1151647 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED21 12947019 1151642 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED22 12947019 1151643 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED23 12947019 1151660 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED24 12947019 1151656 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED24 16945012 1609917 Compound 1 did not affect the [tumor necrosis factor-alpha-] or lipopolysaccharide induced *response* , suggesting selective inhibition of the RANKL induced pathway . Regulation TNF MED25 12947019 1151670 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED26 12947019 1151662 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED27 12947019 1151663 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED28 12947019 1151666 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED29 12947019 1151658 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED30 12947019 1151657 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED31 12947019 1151665 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED4 12947019 1151650 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED6 12947019 1151652 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED7 12947019 1151664 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED8 12947019 1151653 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MED9 12947019 1151667 These results suggest that SHP-2 is a key for the inhibitory *effects* of shear stress on [TNF-alpha] signaling in part via regulating MEKK3/Gab1 interaction , MEKK3 signaling , and subsequent adhesion molecule expression . Regulation TNF MEF2C 14515274 1147107 *regulates* c-Jun but not [TNF-alpha] gene expression in stimulated mast cells . Regulation TNF MEF2C 14515274 1147113 Following phosphorylation of MEF2C , activated *regulates* transcription of c-Jun but not [TNF-alpha] . Regulation TNF MIF 16224818 1489332 Recombinant counter *regulated* in a dose dependent fashion dexamethasone inhibition of [TNF] and IL-8 production by RAW 264.7 macrophages and U-937 promonocytes stimulated with lipopolysaccharides (LPS) or with LPS plus phorbol 12-myristate 13-acetate . Regulation TNF MIPEP 17510837 1745424 Here , DPI significantly reduced the [tumor necrosis factor (TNF)-alpha] and MIP-2 responses to quartz , and the *response* to SPM . Regulation TNF MIR146A 21562054 2470219 *regulates* both transcription silencing and translation disruption of [TNF-a] during TLR4 induced gene reprogramming . Regulation TNF MIR187 23071313 2694950 IL-10 induced negatively *regulates* [TNF-a] , IL-6 , and IL-12p40 production in TLR4 stimulated monocytes . Regulation TNF MIR21 23710745 2792797 To explore the *effect* of on [tumor necrosis factor (TNF)-a] induced cardiomyocytes apoptosis and the association with PTEN/AKT/FOXO3a signaling pathway . Regulation TNF MKL1 20957750 2343722 Interestingly , does not *affect* the induction of IL-6 and [TNF-a] upon TLR3 ligand engagement . Regulation TNF MLST8 22351078 2561125 The aim of this study was to investigate the *role* of in myocardial [TNF-a] expression during endotoxemia . Regulation TNF MMP1 19055644 1999853 Mutation in a putative nuclear factor (NF)-kappaB binding site at -2541 bp almost completely abolished the [TNF-alpha] *response* to gene-promoter activity , suggesting transcriptional regulation of MMP-1 expression by TNF-alpha via this site . Regulation TNF MMP1 23417988 2843403 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by [TNF-a] and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation TNF MMP10 23417988 2843404 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by [TNF-a] and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation TNF MMP11 23417988 2843405 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by [TNF-a] and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation TNF MMP12 23417988 2843406 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by [TNF-a] and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation TNF MMP13 23417988 2843407 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by [TNF-a] and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation TNF MMP14 18277865 1872215 As ERK also appeared to regulate MT1-MMP production , this suggests that [TNF-alpha] induction of MMP-2 gelatinase activity may be *regulated* by . Regulation TNF MMP14 23417988 2843408 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by [TNF-a] and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation TNF MMP15 23417988 2843409 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by [TNF-a] and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation TNF MMP16 23417988 2843410 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by [TNF-a] and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation TNF MMP17 23417988 2843411 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by [TNF-a] and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation TNF MMP19 23417988 2843412 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by [TNF-a] and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation TNF MMP2 1435512 204808 In unstimulated osteoblast-like MC3T3-E1 cell cultures <72-kDa gelatinase> enzyme activity was much greater than 92-kDa activity and was not substantially *regulated* ( less than 40 % change ) by IL-1 , [TNF] or PTH . Regulation TNF MMP2 19038859 2035249 In primary cocultures , MEHP exposure causes a 9.46-fold increase in sTNFA , while the addition of recombinant MMP2 protein results in a 5.4-fold increase in sTNFA , suggesting that MEHP induced is in part *responsible* for the activation of [TNFA] in the testis . Regulation TNF MMP2 21215448 2392066 In conclusion , [TNF-a] can inhibit trophoblast-like cells ( JEG-3 ) integration into maternal endothelial cellular networks , and this process *involves* the inhibition of and a failure of integrins switch from a ( 6 ) ß ( 4 ) to a ( 1 ) ß ( 1 . ) Regulation TNF MMP2 21573233 2430248 In summary , our study implies a *role* of in the regulation of [TNF-a] mediated constitutive NF-?B activation and Fas mediated JNK mediated apoptosis in glioma xenograft cells in vitro and in vivo . Regulation TNF MMP2 23417988 2843413 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by [TNF-a] and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation TNF MMP20 23417988 2843414 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by [TNF-a] and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation TNF MMP21 23417988 2843401 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by [TNF-a] and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation TNF MMP24 23417988 2843415 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by [TNF-a] and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation TNF MMP25 23417988 2843398 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by [TNF-a] and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation TNF MMP26 23417988 2843399 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by [TNF-a] and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation TNF MMP27 23417988 2843400 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by [TNF-a] and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation TNF MMP28 23417988 2843402 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by [TNF-a] and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation TNF MMP3 23417988 2843416 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by [TNF-a] and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation TNF MMP7 10642592 660963 *dependent* release of [tumor necrosis factor-alpha] in a model of herniated disc resorption . Regulation TNF MMP7 23417988 2843417 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by [TNF-a] and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation TNF MMP8 23417988 2843418 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by [TNF-a] and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation TNF MMP9 17362932 1727446 *regulates* [TNF-alpha] and FasL expression in neuronal , glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis . Regulation TNF MMP9 23417988 2843419 Collectively , we show that despite their high homology , SUMO-2/3 are differentially regulated by [TNF-a] and selectively *control* TNF-a mediated expression via the NF-?B pathway . Regulation TNF MMP9 24291441 2898915 Meanwhile , [TNF-a] induced VSMC migration in a *dependent* manner , and PDGF induced VSMC proliferation in a MMP2 dependent manner . Regulation TNF MMP9 24667088 2934886 In conclusion , transcriptional and translational activation of , downstream of p38 MAP kinase signaling , is *involved* in the ( [TNF-a] ) -induced loss of corneal endothelial barrier integrity . Regulation TNF MOB2 16629332 1551916 , which could not rescue the animals from malaria , did not *affect* IL-10 and [TNF-alpha] , but reduced gamma-IFN levels . Regulation TNF MOB4 16629332 1551915 , which could not rescue the animals from malaria , did not *affect* IL-10 and [TNF-alpha] , but reduced gamma-IFN levels . Regulation TNF MOK 19118493 2019357 AGEs ( advanced glycation end-products ) ( receptor for AGEs ) , LOX-1 [ lectin-like oxidized low-density lipoprotein receptor-1 ) and NF-kappaB ( nuclear factor kappaB ) signalling *play* key roles in [TNF-alpha] expression through an increase in circulating and/or local vascular TNF-alpha production . Regulation TNF MORF4L1 7763539 214486 increased glycolysis and IL-1 production by macrophages , but did not *affect* [TNF] production . Regulation TNF MPI 22499423 2583757 The PM-susceptibility to infection was accessed by the at 24 , 72 h and by the mean of these rates ( FPMI ) , as well as by the [TNF-a] , IL-12 ( Capture ELISA ) and Nitric oxide ( NO ) *responses* ( Griess method ) . Regulation TNF MPP1 9551933 499119 We have examined the *roles* of and p75 in mediating and modulating the activity of [TNF] in vivo by generating and examining mice genetically deficient in these receptors . Regulation TNF MRFAP1 7763539 214487 increased glycolysis and IL-1 production by macrophages , but did not *affect* [TNF] production . Regulation TNF MSD 24999366 2948315 The aim of this study was to explore the *effects* of on IL-1 ß and [TNF] a secretion in monocytic THP-1 cells with monosodium urate ( MSU ) crystals induced inflammation . Regulation TNF MSH2 12816950 1120782 In addition , alpha-MSH treatment activated PKA , and PKA inhibition abrogated the inhibitory *effects* of on p38 kinase activation , NF kappa B activation , and [TNF-alpha] production . Regulation TNF MSH2 16413580 1533832 *Effects* of ( CKPV ) 2 , KPV , and [ Nle4-dPhe7 ] <-alpha-MSH> ( NDP-alpha-MSH ) on [tumor necrosis factor alpha (TNF-alpha)] production were determined : 1 ) in human peripheral blood mononuclear cells ( PBMC ) stimulated with lipopolysaccharide (LPS) in vitro , and 2 ) in rats injected with LPS i.v . Regulation TNF MSH2 20619468 2316338 In this work , we examined the *effect* of on the expression of [tumor necrosis factor-a (TNF-a)] and interleukin-1ß (IL-1ß) and their receptors in primary cultured rat hypothalamic neurons . Regulation TNF MSH2 22471953 2637164 *Effects* of , [ DTRP ( 8 ) ] -?-MSH alone or in the presence of the MC ( 3/4 ) receptor antagonist , SHU9119 , on [TNF-a] induced release of pro-inflammatory cytokines , MMPs , apoptotic pathway ( s ) and cell death in C-20/A4 chondrocytes were investigated , along with their effect on the release of the anti-inflammatory cytokine IL-10 . Regulation TNF MSH2 9045742 416620 Presence within normal mouse brain of mRNA for the alpha-MSH receptor MC-1 suggests that the inhibitory *effects* of on brain and plasma [TNF-alpha] might be mediated by this receptor subtype . Regulation TNF MSH2 9045742 416625 The inhibitory *effect* of on brain [TNF-alpha] did not depend on circulating factors because the effect also occurred in brain tissue in vitro . Regulation TNF MSH2 9620667 510573 We tested *effects* of ( 1-13 ) , alpha-MSH ( 11-13 ) , and ACTH ( 1-24 ) on production of [tumor necrosis factor alpha (TNF-alpha)] , interleukin-6 (IL-6) , and nitric oxide ( NO ) in a cultured murine microglial cell line ( N9 ) stimulated with lipopolysaccharide (LPS) plus interferon gamma (IFN-gamma) . Regulation TNF MSH2 9917865 559135 Such influences of the peptide may occur through inhibition of inflammatory agents produced by glia : 1-13 and 11-13 *modulate* [TNF-alpha] and nitric oxide produced by activated murine microglia , and TNF-alpha produced by human astrocytes . Regulation TNF MSH3 12816950 1120783 In addition , alpha-MSH treatment activated PKA , and PKA inhibition abrogated the inhibitory *effects* of on p38 kinase activation , NF kappa B activation , and [TNF-alpha] production . Regulation TNF MSH3 16413580 1533833 *Effects* of ( CKPV ) 2 , KPV , and [ Nle4-dPhe7 ] <-alpha-MSH> ( NDP-alpha-MSH ) on [tumor necrosis factor alpha (TNF-alpha)] production were determined : 1 ) in human peripheral blood mononuclear cells ( PBMC ) stimulated with lipopolysaccharide (LPS) in vitro , and 2 ) in rats injected with LPS i.v . Regulation TNF MSH3 20619468 2316339 In this work , we examined the *effect* of on the expression of [tumor necrosis factor-a (TNF-a)] and interleukin-1ß (IL-1ß) and their receptors in primary cultured rat hypothalamic neurons . Regulation TNF MSH3 22471953 2637165 *Effects* of , [ DTRP ( 8 ) ] -?-MSH alone or in the presence of the MC ( 3/4 ) receptor antagonist , SHU9119 , on [TNF-a] induced release of pro-inflammatory cytokines , MMPs , apoptotic pathway ( s ) and cell death in C-20/A4 chondrocytes were investigated , along with their effect on the release of the anti-inflammatory cytokine IL-10 . Regulation TNF MSH3 9045742 416621 Presence within normal mouse brain of mRNA for the alpha-MSH receptor MC-1 suggests that the inhibitory *effects* of on brain and plasma [TNF-alpha] might be mediated by this receptor subtype . Regulation TNF MSH3 9045742 416626 The inhibitory *effect* of on brain [TNF-alpha] did not depend on circulating factors because the effect also occurred in brain tissue in vitro . Regulation TNF MSH3 9620667 510574 We tested *effects* of alpha-MSH ( 1-13 ) , ( 11-13 ) , and ACTH ( 1-24 ) on production of [tumor necrosis factor alpha (TNF-alpha)] , interleukin-6 (IL-6) , and nitric oxide ( NO ) in a cultured murine microglial cell line ( N9 ) stimulated with lipopolysaccharide (LPS) plus interferon gamma (IFN-gamma) . Regulation TNF MSH3 9917865 559136 Such influences of the peptide may occur through inhibition of inflammatory agents produced by glia : 1-13 and 11-13 *modulate* [TNF-alpha] and nitric oxide produced by activated murine microglia , and TNF-alpha produced by human astrocytes . Regulation TNF MSH4 12816950 1120784 In addition , alpha-MSH treatment activated PKA , and PKA inhibition abrogated the inhibitory *effects* of on p38 kinase activation , NF kappa B activation , and [TNF-alpha] production . Regulation TNF MSH4 16413580 1533834 *Effects* of ( CKPV ) 2 , KPV , and [ Nle4-dPhe7 ] <-alpha-MSH> ( NDP-alpha-MSH ) on [tumor necrosis factor alpha (TNF-alpha)] production were determined : 1 ) in human peripheral blood mononuclear cells ( PBMC ) stimulated with lipopolysaccharide (LPS) in vitro , and 2 ) in rats injected with LPS i.v . Regulation TNF MSH4 20619468 2316340 In this work , we examined the *effect* of on the expression of [tumor necrosis factor-a (TNF-a)] and interleukin-1ß (IL-1ß) and their receptors in primary cultured rat hypothalamic neurons . Regulation TNF MSH4 22471953 2637166 *Effects* of , [ DTRP ( 8 ) ] -?-MSH alone or in the presence of the MC ( 3/4 ) receptor antagonist , SHU9119 , on [TNF-a] induced release of pro-inflammatory cytokines , MMPs , apoptotic pathway ( s ) and cell death in C-20/A4 chondrocytes were investigated , along with their effect on the release of the anti-inflammatory cytokine IL-10 . Regulation TNF MSH4 9045742 416622 Presence within normal mouse brain of mRNA for the alpha-MSH receptor MC-1 suggests that the inhibitory *effects* of on brain and plasma [TNF-alpha] might be mediated by this receptor subtype . Regulation TNF MSH4 9045742 416627 The inhibitory *effect* of on brain [TNF-alpha] did not depend on circulating factors because the effect also occurred in brain tissue in vitro . Regulation TNF MSH4 9620667 510575 We tested *effects* of alpha-MSH ( 1-13 ) , ( 11-13 ) , and ACTH ( 1-24 ) on production of [tumor necrosis factor alpha (TNF-alpha)] , interleukin-6 (IL-6) , and nitric oxide ( NO ) in a cultured murine microglial cell line ( N9 ) stimulated with lipopolysaccharide (LPS) plus interferon gamma (IFN-gamma) . Regulation TNF MSH4 9917865 559137 Such influences of the peptide may occur through inhibition of inflammatory agents produced by glia : 1-13 and 11-13 *modulate* [TNF-alpha] and nitric oxide produced by activated murine microglia , and TNF-alpha produced by human astrocytes . Regulation TNF MSH5 12816950 1120785 In addition , alpha-MSH treatment activated PKA , and PKA inhibition abrogated the inhibitory *effects* of on p38 kinase activation , NF kappa B activation , and [TNF-alpha] production . Regulation TNF MSH5 16413580 1533835 *Effects* of ( CKPV ) 2 , KPV , and [ Nle4-dPhe7 ] <-alpha-MSH> ( NDP-alpha-MSH ) on [tumor necrosis factor alpha (TNF-alpha)] production were determined : 1 ) in human peripheral blood mononuclear cells ( PBMC ) stimulated with lipopolysaccharide (LPS) in vitro , and 2 ) in rats injected with LPS i.v . Regulation TNF MSH5 20619468 2316341 In this work , we examined the *effect* of on the expression of [tumor necrosis factor-a (TNF-a)] and interleukin-1ß (IL-1ß) and their receptors in primary cultured rat hypothalamic neurons . Regulation TNF MSH5 22471953 2637167 *Effects* of , [ DTRP ( 8 ) ] -?-MSH alone or in the presence of the MC ( 3/4 ) receptor antagonist , SHU9119 , on [TNF-a] induced release of pro-inflammatory cytokines , MMPs , apoptotic pathway ( s ) and cell death in C-20/A4 chondrocytes were investigated , along with their effect on the release of the anti-inflammatory cytokine IL-10 . Regulation TNF MSH5 9045742 416623 Presence within normal mouse brain of mRNA for the alpha-MSH receptor MC-1 suggests that the inhibitory *effects* of on brain and plasma [TNF-alpha] might be mediated by this receptor subtype . Regulation TNF MSH5 9045742 416628 The inhibitory *effect* of on brain [TNF-alpha] did not depend on circulating factors because the effect also occurred in brain tissue in vitro . Regulation TNF MSH5 9620667 510576 We tested *effects* of ( 1-13 ) , alpha-MSH ( 11-13 ) , and ACTH ( 1-24 ) on production of [tumor necrosis factor alpha (TNF-alpha)] , interleukin-6 (IL-6) , and nitric oxide ( NO ) in a cultured murine microglial cell line ( N9 ) stimulated with lipopolysaccharide (LPS) plus interferon gamma (IFN-gamma) . Regulation TNF MSH5 9917865 559138 Such influences of the peptide may occur through inhibition of inflammatory agents produced by glia : 1-13 and 11-13 *modulate* [TNF-alpha] and nitric oxide produced by activated murine microglia , and TNF-alpha produced by human astrocytes . Regulation TNF MSH6 12816950 1120786 In addition , alpha-MSH treatment activated PKA , and PKA inhibition abrogated the inhibitory *effects* of on p38 kinase activation , NF kappa B activation , and [TNF-alpha] production . Regulation TNF MSH6 16413580 1533836 *Effects* of ( CKPV ) 2 , KPV , and [ Nle4-dPhe7 ] <-alpha-MSH> ( NDP-alpha-MSH ) on [tumor necrosis factor alpha (TNF-alpha)] production were determined : 1 ) in human peripheral blood mononuclear cells ( PBMC ) stimulated with lipopolysaccharide (LPS) in vitro , and 2 ) in rats injected with LPS i.v . Regulation TNF MSH6 20619468 2316342 In this work , we examined the *effect* of on the expression of [tumor necrosis factor-a (TNF-a)] and interleukin-1ß (IL-1ß) and their receptors in primary cultured rat hypothalamic neurons . Regulation TNF MSH6 22471953 2637168 *Effects* of , [ DTRP ( 8 ) ] -?-MSH alone or in the presence of the MC ( 3/4 ) receptor antagonist , SHU9119 , on [TNF-a] induced release of pro-inflammatory cytokines , MMPs , apoptotic pathway ( s ) and cell death in C-20/A4 chondrocytes were investigated , along with their effect on the release of the anti-inflammatory cytokine IL-10 . Regulation TNF MSH6 9045742 416624 Presence within normal mouse brain of mRNA for the alpha-MSH receptor MC-1 suggests that the inhibitory *effects* of on brain and plasma [TNF-alpha] might be mediated by this receptor subtype . Regulation TNF MSH6 9045742 416629 The inhibitory *effect* of on brain [TNF-alpha] did not depend on circulating factors because the effect also occurred in brain tissue in vitro . Regulation TNF MSH6 9620667 510577 We tested *effects* of alpha-MSH ( 1-13 ) , ( 11-13 ) , and ACTH ( 1-24 ) on production of [tumor necrosis factor alpha (TNF-alpha)] , interleukin-6 (IL-6) , and nitric oxide ( NO ) in a cultured murine microglial cell line ( N9 ) stimulated with lipopolysaccharide (LPS) plus interferon gamma (IFN-gamma) . Regulation TNF MSH6 9917865 559139 Such influences of the peptide may occur through inhibition of inflammatory agents produced by glia : 1-13 and 11-13 *modulate* [TNF-alpha] and nitric oxide produced by activated murine microglia , and TNF-alpha produced by human astrocytes . Regulation TNF MSN 11717582 882065 Separate experiments evaluated *effects* on monocyte chemotaxis , IL-1 production in response to IL-1 stimulation , and [TNF-alpha] secretion in response to Staphylococcus aureus stimulation . Regulation TNF MSN 19965872 2199595 [Tumor necrosis factor-alpha] *regulates* transforming growth factor-beta dependent epithelial-mesenchymal transition by promoting interaction . Regulation TNF MT-CO2 15529314 1355143 We compared the *effect* of and Cr3+ ions on the expression of bone resorbing cytokines ( [TNF-alpha] , IL-6 , IL-1beta ) in U937 macrophages cultured on PC-coated surfaces to the response of U937 macrophages in suspension . Regulation TNF MT-CO2 15778246 1417147 Buffering the media abated the *effects* of on [TNF-alpha] secretion . Regulation TNF MTOR 22351078 2561127 The aim of this study was to investigate the *role* of in myocardial [TNF-a] expression during endotoxemia . Regulation TNF MTTP 9698520 524939 *Effect* of on [TNF-alpha] in perfused rat liver after bacteremia and ischemia/reperfusion . Regulation TNF MTX1 21194185 2373902 Neither nor BSO had an *effect* on the mRNA expressions of IL-4 , transforming growth factor ß ( TGF-ß ) , and [tumor necrosis factor-a (TNF-a)] in the spleen . Regulation TNF MTX1 22980653 2674127 To determine the *effects* of glycyrrhetinic acid ( GA ) , and GA+MTX on the expressions of [tumor necrosis factor-a (TNF-a)] and interleukin-1ß (IL-1ß) in fibroblast-like synovial ( FLS ) cells from collagen induced arthritis ( CIA ) rats . Regulation TNF MTX1 23754245 2849091 To determine the *effect* of on plasma levels of interleukin (IL)-6 and [tumor necrosis factor (TNF)-a] and to investigate their associations with clinical and radiographic responses in patients with early rheumatoid arthritis ( RA ) . Regulation TNF MTX1 8280790 247353 Neither ( 20-2.5 nmol/10 ( 5 ) cells ) nor MTX-LIPO ( 5.6 nmol/10 ( 5 ) cells ) *affected* [TNF alpha] release from LPS stimulated macrophages . Regulation TNF MTX1 9106331 424499 Experimental and clinical studies have yet to determine the extent to which or cyclosporine A ( CSA ) treatment alone *affects* the expression in vivo of [tumour necrosis factor-alpha (TNF alpha)] , a cytokine produced primarily by macrophages and believed to be directly involved in the pathogenesis of cardiac allograft rejection . Regulation TNF MTX1 9889412 558481 We investigated the *effects* of on the production of [tumor necrosis factor (TNF)] , nitric oxide ( NO ) and interleukin-10 (IL-10) in vivo . Regulation TNF MUC1 7536782 300304 In contrast with J774.1 cells and thioglycolate medium elicited macrophages ( T-PEM ) , exhibited serum independent TNF-alpha production , and a polyclonal Ab to murine CD14 had no inhibitory *effect* on the LPS induced [TNF-alpha] production by P-PEM . Regulation TNF MUC2 12848848 1109121 These findings sustain a novel phenomenon that mRNA expression is differently *controlled* by IL-4 , IL-13 , or [TNF-alpha] in LS174T and HT29 cells , whereas the mitogen activated protein kinase pathway plays a role in the MUC2 mRNA expression induced by those cytokines in both cell lines . Regulation TNF MYCN 15953367 1421748 An increase in expression , however , did not *affect* microglial production of NO or [TNFalpha] . Regulation TNF MYD88 12139759 969326 is *involved* in the signalling pathway for Taxol induced apoptosis and [TNF-alpha] expression in human myelomonocytic cells . Regulation TNF MYD88 12244183 990587 These results indicated a critical role for *dependent* [IL-12/TNF-alpha] production and for IL-12- and IL-18 mediated IFN-gamma production in early phase clearance of LM . Regulation TNF MYD88 14977922 1213307 *Role* of in diminished [tumor necrosis factor] alpha production by newborn mononuclear cells in response to lipopolysaccharide . Regulation TNF MYD88 16709840 1564609 The induction of [TNF-alpha] , IL-12 p40 , and MIP-2 ( CXCL2 ) expression by S. aureus- and peptidoglycan stimulated microglia was *dependent* , as revealed by the complete inhibition of cytokine production in MyD88 KO cells . Regulation TNF MYD88 18691413 1955420 TLR adaptor molecule strongly *regulated* [TNF-alpha] production in response to heat killed B. pseudomallei . Regulation TNF MYD88 19004989 2029006 These data , combined with the strict MyD88 dependent production of TNF in Salmonella infected mice , suggest that *dependent* [TNF] mediates DC death . Regulation TNF MYD88 19539649 2103609 IL-12 and [TNF-alpha] production by dendritic cells stimulated with Schistosoma mansoni schistosomula tegument is TLR4- and *dependent* . Regulation TNF MYD88 19540914 2116362 Moreover , addition of exogenous TNF allowed the recovery of full PRX5 expression in both MyD88 ( -/- ) and TNF ( -/- ) cells stimulated with IFN-gamma , suggesting that basal [TNF] produced in an *dependent* manner contributes to PRX5 induction . Regulation TNF MYD88 19783673 2147627 In macrophages prestimulated with IFN-gamma , sHz also results in a *dependent* release of [TNF-alpha] . Regulation TNF MYD88 20699281 2479918 Our results indicated that elevated [tumor necrosis factor-a] , interferon-? , interleukin (IL)-1a/ß and IL-6 production from mouse spleen cells treated with SEB alone or in combination with lipopolysaccharide (LPS) was *regulated* by . Regulation TNF MYD88 21182083 2373743 Analysis of upstream signaling events revealed that TLR 2/4 mediated *dependent* participation of IL-1R activated kinase (IRAK)1 , [TNF receptor associated factor (TRAF)6] and TGFß activated kinase (TAK)1 is essential to induce cystatin mediated I?B kinase ( IKK ) /NF-?B activation in macrophages . Regulation TNF MYD88 21248248 2386883 Although does not significantly *affect* TLR3 ligand induced [TNF-a] induction , MyD88 negatively regulates TLR3- , but not TLR4- , mediated IFN-ß and RANTES production ; Regulation TNF MYD88 22262768 2564513 Heme induced cell death required TNFR1 and *dependent* [TNF] production . Regulation TNF MYD88 22262768 2564517 Taken together , these results revealed that heme induces macrophage necrosis through 2 synergistic mechanisms : *dependent* expression of [TNF] and TLR4 independent generation of ROS . Regulation TNF MYD88 22385341 2587443 Rv0652 stimulated [TNF] and MCP-1 secretion by macrophages occurred in a Toll-like receptor 4-dependent and *dependent* manner . Regulation TNF MYL2 11384975 842393 Changes in the activation of caspase-8 that parallel changes in regulatory light chain phosphorylation levels reveal that motor activities *regulate* [TNF receptor-1 (TNFR-1)] signaling at an early step in the TNF death signaling pathway . Regulation TNF MYLIP 22581933 2619523 Transfection of the miR-125b precursor into neonatal monocytes significantly repressed the TNF-a mRNA and protein expression , suggesting that negatively *regulates* [TNF-a] expression in neonatal monocytes . Regulation TNF MYLIP 22950459 2693383 Our data suggest a potential *role* for in the regulation of [TNF-a] expression after ischemia/hypoxia and microglia mediated neuronal injury . Regulation TNF MYLIP 23028621 2679704 Modulation of expression *affected* also the release of several cytokines such as IL-6 and [TNF-a] . Regulation TNF MYLIP 23060456 2757391 [TNF-a] , *regulated* by and miR-146a , was decreased in the LPS pretreated group at all time points ( P < 0.05 ) , as were HMGB1 , a key alarmin regulated by miR-146 , -142-3p , -299 and -200c ( P < 0.05 ) , and IL-1ß and IL-6 , both regulated by miR-132and miR-21 respectively ( P < 0.05 ) . Regulation TNF MYLIP 23606743 2800184 Moreover , our results demonstrate that expression levels are negatively *controlled* by [tumor necrosis factor a (TNF-a)] . Regulation TNF MYLIP 23795660 2802761 Further , we observed that directly *regulated* [TNF-a] expression because miR-19a can suppress the expression of wild-type TNF-a reporter , but not the mutant form . Regulation TNF MYLIP 23795660 2802763 Taken together , this study determines the levels of miR-19a and TNF-a in both DSS induced experimental murine colitis and human UC and further demonstrates that might directly *regulate* [TNF-a] . Regulation TNF MYLIP 23974950 2902072 In addition , miR-146a mimics decreased , while inhibitor increased , the expression of inflammatory cytokine interleukin-6 , but did not *affect* [tumor necrosis factor-a] expression in LPS stimulated RAW264.7 macrophage cells . Regulation TNF MYLIP 24442429 2912803 The *role* of in regulation of induction of [TNF-a] was confirmed by transfecting cells with an inhibitor and a mimic of miR-146a . Regulation TNF MYLK 18363837 1957967 Previous studies have shown that [TNF-alpha] increase in TJ permeability was *regulated* by an increase in gene activity and protein expression . Regulation TNF NA 11970856 933214 We found that the DNA binding activity of nuclear transcription factor-kappaB in peripheral blood cells was inhibited by given before lipopolysaccharide , whereas [tumor necrosis factor-alpha] secretion was not *affected* . Regulation TNF NA 1544168 183392 In this study we investigated the *effect* of on [TNF] production and LPS lethality in mice . Regulation TNF NA 20560295 2181614 In this study we investigated the *effect* of on the production of tumor necrosis factor (TNF)-alpha , interleukin (IL)-1beta , IL-6 , IL-8 , IL-10 , IL-12 ( p70 ) , IL-18 , transforming growth factor (TGF)-beta1 , and the soluble [TNF] receptors ( sTNFR1 and sTNFR2 ) by alveolar macrophages ( AM ) in IPF patients . Regulation TNF NA 24048773 2846369 To the best of our knowledge , this is the first study that has evaluated the *effect* of on [TNF-a] and TGF-ß levels in patients with AMI . Regulation TNF NA 9721806 528756 The *effects* of BHT and on [TNF-alpha] production were studied both with and without lipopolysaccharide (LPS) activation of alveolar macrophages from bronchoalveolar lavage fluid . Regulation TNF NAALADL1 11435497 832574 The PKC inhibitor H7 reduced LTA dependent secretion of TNF-alpha by 94 % but inhibited poly *dependent* [TNF-alpha] production only by 50 % . Regulation TNF NAALADL1 21968540 2525945 Interferon-beta , but not [tumor necrosis factor-alpha] , production in *response* to poly is maintained despite exhaustive exercise in mice . Regulation TNF NAALADL1 21968540 2525948 Although [TNF-a] in *response* to poly was significantly inhibited by exhaustive exercise , IFN-ß was no different in both groups . Regulation TNF NAMPT 18343625 1919659 Our results also demonstrate that the tumor necrosis factor (TNF)alpha increases porcine visfatin gene expression in stromal-vascular ( SV ) cell cultures , thus suggesting an intermediary role for [TNFalpha] in *response* . Regulation TNF NCF1 15743827 1379084 Acute [tumor necrosis factor] alpha signaling via NADPH oxidase in microvascular endothelial cells : *role* of phosphorylation and binding to TRAF4 . Regulation TNF NCF1 23639811 2805075 Cumulatively , these results demonstrate that NOX2 and its activator subunits ( and Rac ) control the secretion of TNF-a by the liver following I/R. Interestingly , in the absence of Kupffer cells and NOX2 , NOX1 *played* a dominant role in [TNF-a] production following hepatic I/R . Regulation TNF NCL 19060367 2000033 [ *Role* of cell-surface in lipopolysaccharide stimulated expression and secretion of [TNF-alpha] and IL-1beta ] . Regulation TNF NCL 19060367 2000039 To explore the *role* of cell-surface in lipopolysaccharide (LPS) stimulated expression and secretion of [TNF-alpha] and IL-1beta in human THP-1 monocytes . Regulation TNF NCR1 22457623 2578426 Finally , we show in vitro that the interaction of NK cells with F. nucleatum leads to an *dependent* secretion of [TNF-a] . Regulation TNF NELFCD 12122596 965243 serum cytokine profiles and soluble [TNF-receptor] *response* in patients with chronic hepatitis C during recombinant human interleukin-12 ( rHuIL-12 ) treatment . Regulation TNF NELFCD 20153259 2248514 Using PBMC from healthy individuals , we show that monocytes differentiated with IL-15 ( IL15-DC ) produced IL-1beta , IL-6 , IL-15 , IL-23 , [TNFalpha] and CCL20 in *response* to pepsin-trypsin digested gliadin (PTG) and activated contact dependent Th17 and responses from autologous CD4 ( + ) T cells . Regulation TNF NELFCD 20559676 2302539 In conclusion , plasma levels of CXCL9 , sTNFR1 , and sTNFR2 were independently associated with liver histological changes , suggesting a role of [TNF] activation and cell mediated immune *response* in the pathogenesis of HCV infection . Regulation TNF NELFCD 21054766 2365676 During fetal development , interleukin (IL)-23 , IL-10 and IL-6 , as well as T-helper-17 ( Th17 ) -mediated immune responses , are upregulated , whereas [tumour necrosis factor-a (TNF-a)] and IL-1ß- and mediated immune *responses* are downregulated in the intrauterine environment ( both the fetal compartment and the amniotic compartment ) . Regulation TNF NELFCD 22834815 2706104 Artesunate suppresses [TNF-a] expression in vitro and in vivo as well as *responses* in TNBS colitis model . Regulation TNF NFAT5 11485737 844902 Using dominant negative proteins that inhibit NFAT5 dimerization , we show that *regulates* expression of the [TNFalpha] and lymphotoxin-beta genes in osmotically stressed T cells . Regulation TNF NFATC2 19060202 2001757 We also show that these NFATp subdomains interact with the coactivator CBP ( CREB binding protein ) , which is required for *dependent* [TNF] gene transcription . Regulation TNF NFATC2 22844476 2635712 These results thus demonstrate that NFATp plays a critical role in immune containment of TB disease in vivo , through the *dependent* expression of [TNF] and IFN-? in T cells . Regulation TNF NFATC2 7982959 281701 The *role* of in cyclosporin A-sensitive [tumor necrosis factor-alpha] gene transcription . Regulation TNF NFATC2 7982959 281702 The *involvement* of in transcriptional activation of both the interleukin-2 and [TNF alpha] genes suggests that this factor plays an important role in the coordinate induction of multiple cytokine genes , starting at the earliest stages of T cell activation . Regulation TNF NFATC2 8552071 347105 [Tumor necrosis factor] alpha gene regulation in activated T cells *involves* ATF-2/Jun and . Regulation TNF NFATC2 8816436 383616 Cell-type-specific *regulation* of the human [tumor necrosis factor] alpha gene in B cells and T cells by and ATF-2/JUN . Regulation TNF NFATC2 8816436 383621 In A20 B cells , the [TNF-alpha] gene is not *regulated* by bound to the kappa 3 element . Regulation TNF NFKB1 10402163 628901 The *plays* an essential role in transcriptional activation of [TNF] and IL-1 . Regulation TNF NFKB1 10449410 637275 The molecular basis for this resistance relies on an almost complete abrogation of *dependent* accumulation of [TNF-alpha] in the serum and a down-regulation of inducible nitric oxide synthase (iNOS) , leading to decreased NO synthesis , which is the main source of free radical generation during inflammation . Regulation TNF NFKB1 10486238 644709 *Role* of transcription factor in asbestos induced [TNFalpha] response from macrophages . Regulation TNF NFKB1 10498648 647630 The aim of this study is to investigate how PAF participates in the LPS induced and mediated *regulation* of [TNF-alpha] and CINC in regenerating rat livers . Regulation TNF NFKB1 10569191 567991 These results indicate that silica mediated free radical generation and activation *play* important roles in silica induced [TNFalpha] gene expression . Regulation TNF NFKB1 10616907 575889 We report that [TNF] induces DNA replication in growth arrested LE6 cells and that its effect *involves* the activation of and STAT3 and an increase in c-myc and IL-6 mRNAs . Regulation TNF NFKB1 10617597 657076 Incubation of macrophages with PAO1 led to *dependent* expression of inducible nitric-oxide synthase , COX-2 , and [tumor necrosis factor-alpha] , which was unaffected by inhibition of Rac1 or Cdc42 function . Regulation TNF NFKB1 10640779 660714 We tested whether *affects* [TNF-alpha] production by AMs using N-tosyl- < cmd SC > l < cmd /SC > -phenylalanine chloromethylketone ( TPCK ) or N-benzoyl- < cmd SC > l < cmd /SC > -tyrosine ethyl ester ( BTEE ) , which inhibit the degradation of I kappa B , or tricyclodecan-9-yl-xanthogenate-potassium ( D609 ) , which inhibits phospholipase C. Alveolar macrophages were exposed to LPS alone and with the chemical protease inhibitors TPCK , BTEE , and D609 . Regulation TNF NFKB1 10640779 660718 Our data show that [TNF-alpha] production by LPS stimulated AMs from asymptomatic HIV-seropositive and -seronegative individuals is *regulated* via the phospholipase C pathway and by DNA binding activity without obvious changes in I kappa B-alpha or I kappa B-beta protein concentrations . Regulation TNF NFKB1 10754326 682615 [TNF-alpha] gene expression in macrophages : *regulation* by is independent of c-Jun or C/EBP beta . Regulation TNF NFKB1 11093952 755139 [TNF-alpha] is *regulated* , and its upregulation in NF-kappaB1 knockouts may result from an alleviation of p50-p50 repression . Regulation TNF NFKB1 11279049 819487 These data show that [TNF-alpha] decreases AQP5 mRNA and protein expression and that the molecular pathway for this effect *involves* TNFR1 and activated . Regulation TNF NFKB1 11312646 805301 tightly *regulates* [TNF-alpha] transcription . Regulation TNF NFKB1 11367517 816871 Dexamethasone was used as a positive control due to its well characterised mechanism of action and *effects* on [TNF-alpha] expression . Regulation TNF NFKB1 11391531 822938 Because p53 is up-regulated by [TNF-alpha] in an *dependent* manner and the Mdr1b promoter contains a p53 binding site , we used liver cells expressing a dominant negative p53 to show that TNF-alpha up-regulation of Mdr1b is independent of functional p53 . Regulation TNF NFKB1 11675371 873169 Furthermore , transient transfection with a super-repressive mutant of IkappaBalpha ( IkappaBalpha-AA ) demonstrated that *plays* a critical role in CpG DNA mediated [TNF-alpha] expression . Regulation TNF NFKB1 11699072 878323 To determine the role of the human coronary artery endothelial cell ( HCA-EC ) in the cytokine response to endotoxin we measured in vitro TNF-alpha synthesis , [TNF-alpha] mRNA , and the associated *response* to LPS . Regulation TNF NFKB1 11922866 984260 Respiratory syncytial virus and [TNF alpha] induction of chemokine gene expression *involves* differential activation of Rel A and . Regulation TNF NFKB1 12115625 964238 As chemokines are important for the progress of an inflammatory response by the recruitment of immuno-competent cells , the role *plays* in [TNFalpha-] or lipopolysaccharides (LPS) induced chemokine secretion by human monocyte derived macrophages was examined . Regulation TNF NFKB1 12133965 967044 Mitogen activated protein kinases and are *involved* in [TNF-alpha] responses to group B streptococci . Regulation TNF NFKB1 12133965 967052 Here we investigate the *role* of mitogen activated protein kinases ( MAPKs ) and in [TNF-alpha] production by human monocytes stimulated with GBS or LPS , used as a positive control . Regulation TNF NFKB1 12161100 971870 Expression of [TNF-alpha] and IL-6 was *regulated* by a transcription factor , . Regulation TNF NFKB1 12181188 977490 Addition of Fe2+ but not Fe3+ ( approximately 5-50 microM ) to cultured rat Kupffer cells increased TNF-alpha release and [TNF-alpha] promoter activity in a *dependent* manner . Regulation TNF NFKB1 12203103 983120 The *role* of in enhancement of [TNF-alpha] production was confirmed in experiments in which MG132 , an inhibitor of NF-kappaB activation , reversed the effect of AdAMP . Regulation TNF NFKB1 12543078 1028751 Together , the p43 induced [TNF] production was *controlled* by , p38 MAPK , and ERK that is dependent on the activities of PLC and PKC . Regulation TNF NFKB1 12815041 1120756 Stimulation of macrophages with GPIs of T. gondii results in activation of the transcription factor NF-kappa B , which is inhibited by the chemically synthesized GPIb , suggesting the *involvement* of in [TNF alpha] gene expression . Regulation TNF NFKB1 12874341 1115082 Activation of and AP-1 by P. aeruginosa GLP may be *involved* not only in [TNF-alpha] induction but also in many of the inflammatory responses triggered in the course of infection with P. aeruginosa . Regulation TNF NFKB1 12885587 1116717 It is concluded that T ( 3 ) -induced oxidative stress enhances the DNA binding activity of NF-kappaB and the *dependent* expression of [TNF-alpha] and IL-10 genes . Regulation TNF NFKB1 12957294 1137884 Moreover , the iron treatment increased TNF-alpha release and [TNF-alpha] promoter activity in a *dependent* manner . Regulation TNF NFKB1 14575704 1156226 *dependent* regulation of [tumor necrosis factor-alpha] gene expression by CpG-oligodeoxynucleotides . Regulation TNF NFKB1 14646597 1173172 is *involved* in the [TNF-alpha] induced inhibition of the differentiation of 3T3-L1 cells by reducing PPARgamma expression . Regulation TNF NFKB1 14736953 1199597 We investigated the *role* of and AP-1 in [tumour necrosis factor alpha (TNF-alpha)] induced monocyte chemoattractant protein 1 ( MCP-1 ) production in cultured human glomerular endothelial cells ( HGEC ) . Regulation TNF NFKB1 14996411 1216226 These results indicate that *plays* a potential role in the induction of NO and [TNF-alpha] by oligochitosan in macrophages . Regulation TNF NFKB1 15016878 1220932 Moreover , MVA/K1L gained the ability to repress artificially contrived and natural *regulated* expression of a transfected luciferase and the cellular [tumor necrosis factor] gene , respectively . Regulation TNF NFKB1 15062645 1230788 TNF transcripts are expressed in both mammals and fish with similar kinetics , and the *involvement* of in [TNF] expression in fish suggests that transcriptional regulation may be similar within vertebrates . Regulation TNF NFKB1 15265367 1275310 The *results* of EMSA showed that activation by [TNF-alpha] in HL-60 cells was induced in a dose dependent manner , but was almost completely inhibited by mutant IkappaBalpha repressor in transfected cells . Regulation TNF NFKB1 15464079 1305008 Anti-inflammatory drugs and [tumor necrosis factor-alpha] production from monocytes : *role* of transcription factor and implication for rheumatoid arthritis therapy . Regulation TNF NFKB1 15481297 1320376 *regulates* the expression of [TNF] . Regulation TNF NFKB1 15723831 1396170 *dependent* down-regulation of [tumor necrosis factor] receptor associated proteins contributes to interleukin-1 mediated enhancement of ultraviolet B-induced apoptosis . Regulation TNF NFKB1 15851579 1399556 [TNF-alpha] regulates expression of some of these factors in an *dependent* manner , whereas others are not influenced by NF-kappaB . Regulation TNF NFKB1 15980040 1465298 Taken together , these data provide compelling evidence for the *role* of signaling in [TNF-alpha] gene expression in heart and highlight the importance of this proinflammatory gene-regulatory pathway as a potential therapeutic target in the management of cytokine induced myocardial dysfunction . Regulation TNF NFKB1 16023083 1435123 This correlated with expression of [TNF] , IkappaBalpha , Bcl-2 , Bcl-xl , COX-2 and IL-6 , all *regulated* by . Regulation TNF NFKB1 16054790 1473757 These findings demonstrate that the inhibition of the LPS/rIFN-gamma induced production of NO and [TNF-alpha] by LR *involves* the inhibition of activation . Regulation TNF NFKB1 16112155 1546730 It is known that tightly *regulates* [TNF] transcription . Regulation TNF NFKB1 16116219 1449053 Such chemokine secretion is dependent , likely to involve AP-1 , and is *regulated* in a paracrine loop by monocyte derived [TNF-alpha] . Regulation TNF NFKB1 16125268 1454432 Intracellular distribution of decoy and its inhibitory *effect* on [TNFalpha] production by LPS stimulated RAW 264.7 cells . Regulation TNF NFKB1 16135673 1450329 Recently , we demonstrated that 3,3',5-triiodothyronine ( T3 ) induces oxidative stress in rat liver , with enhancement in the DNA binding of nuclear factor-kappaB (NF-kappaB) and the *dependent* expression of [tumor necrosis factor-alpha (TNF-alpha)] . Regulation TNF NFKB1 16177323 1458146 Our data indicate that the increased Ets/Elk and promoter activities associated with M. smegmatis infected macrophages are *responsible* , at least in part , for the increased [TNF-alpha] and NOS2 production observed in these infected cells and that ERK1/2 is required for Ets/Elk activity and full TNF-alpha production . Regulation TNF NFKB1 16357489 1519419 The inhibitory effect of DAAE on the [TNF-alpha] and IL-6 expression was *dependent* . Regulation TNF NFKB1 16580131 1562450 Taken together , these results suggest that the induction of IL-1beta and [TNFalpha] in endotoxin stimulated microglia is differentially *regulated* at the level of activation . Regulation TNF NFKB1 16581782 1543858 Gene expression analysis revealed that ER stress induced expression of [tumor necrosis factor alpha (TNF-alpha)] was IRE1alpha and *dependent* . Regulation TNF NFKB1 16705808 1496608 DEP induced [TNF-alpha] gene expression is *regulated* at the transcriptional level by . Regulation TNF NFKB1 16873280 1593286 Rhinovirus replication in human macrophages induces *dependent* [tumor necrosis factor] alpha production . Regulation TNF NFKB1 16888021 1596851 We found that LPS induced activation of , a *regulator* of [TNF-alpha] , was inhibited by both ethanol treatment and HO-1 activation , but the ethanol induced inhibition of NF-kappaB was HO-1 independent . Regulation TNF NFKB1 17041226 1631072 Human cytomegalovirus IE86 attenuates virus- and [tumor necrosis factor] alpha induced *dependent* gene expression . Regulation TNF NFKB1 17240450 1696448 Our studies using human U937 promonocytes cells suggested that magnolol , a low molecular weight lignan isolated from the medicinal plant Magnolia officinalis , differentially down-regulated the pharmacologically induced expression of *regulated* inflammatory gene products MMP-9 , IL-8 , MCP-1 , MIP-1alpha , [TNF-alpha] . Regulation TNF NFKB1 17312171 1699703 rCD40L synergized with HIV-1 Tat to increase [TNF-alpha] release from primary human monocytes and microglia , in an *dependent* manner . Regulation TNF NFKB1 17434489 1729015 We also observed that is *involved* in AGE-BSA induced [TNF-alpha] . Regulation TNF NFKB1 17485788 1739223 We postulate that green tea polyphenols *regulate* [TNF-alpha] gene expression by modulating activation through their inhibition effect on IKB Kinase (IKK) activity and as scavenger of free radicals . Regulation TNF NFKB1 17828497 1795611 To investigate the *role* of in [TNF-alpha] induced apoptosis in HSC-T6 , a mutant IkappaBalpha was transfected into HSC-T6 cells by lipofectin transfection technique and its transient effect was examined 48 h after the transfection . Regulation TNF NFKB1 17934460 1819723 Using genetic and molecular approaches , we show that Birc2 positively *regulates* the formation of the [TNF] receptor complex I in endothelial cells , thereby promoting activation and maintaining vessel integrity and stabilization . Regulation TNF NFKB1 18025177 1827646 In this study , we demonstrate that PECAM-1 ligation with CD38-Fc fusion protein negatively *regulates* LPS induced proinflammatory cytokine [TNF-alpha] , IL-6 , and IFN-beta production by inhibiting JNK , , and IFN regulatory factor 3 activation in macrophages . Regulation TNF NFKB1 18393939 1913459 In conclusion , we find that can *regulate* basal [TNFalpha] and , in certain circumstances , the hypoxia induced HIF-1alpha . Regulation TNF NFKB1 18832697 1971196 Glucocorticoid induced [TNF] receptor expression by T cells is reciprocally *regulated* by and NFAT . Regulation TNF NFKB1 19023660 2035113 This study examines the *role* of in the regulation of [TNFalpha] production by morphine in microglia . Regulation TNF NFKB1 19096114 2003930 To test this hypothesis , we studied the effect of CoQ10 on the *dependent* pro-inflammatory cytokine [TNF-alpha] . Regulation TNF NFKB1 19118493 2019355 AGEs ( advanced glycation end-products ) /RAGE ( receptor for AGEs ) , LOX-1 [ lectin-like oxidized low-density lipoprotein receptor-1 ) and ( nuclear factor kappaB ) signalling *play* key roles in [TNF-alpha] expression through an increase in circulating and/or local vascular TNF-alpha production . Regulation TNF NFKB1 19287189 2046626 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Regulation TNF NFKB1 19299582 2064132 Taken together , our findings suggest that signaling is *involved* in regulating LPS- and metabolites-of-ethanol mediated [TNF-alpha] production in rat Kupffer cells and in murine macrophages . Regulation TNF NFKB1 19326995 2052540 To investigate the underlying mechanism ( s ) for the increased TNF-alpha expression , the role of , an important *regulator* of [TNF-alpha] gene transcription , was examined . Regulation TNF NFKB1 19487969 2185521 Ron receptor tyrosine kinase negatively *regulates* [TNFalpha] production in alveolar macrophages by inhibiting activity and Adam17 production . Regulation TNF NFKB1 19596777 2122961 These results suggest that GSK-3beta *regulates* heat inactivated S. aureus induced [TNF-alpha] and NO production in microglia mainly by activating and probably by inhibiting IL-10 . Regulation TNF NFKB1 19721818 2133740 In vitro studies with the ester dimethyl fumarate ( DMF ) described an inhibitory effect on *dependent* transcription of [tumor necrosis factor-alpha (TNF-alpha)] induced genes in human endothelial cells . Regulation TNF NFKB1 20039412 2192620 *Involvement* of MAPKs and in [tumor necrosis factor] alpha induced vascular cell adhesion molecule 1 expression in human rheumatoid arthritis synovial fibroblasts . Regulation TNF NFKB1 20049872 2200696 In this study , we determined the effect of TNF-alpha on osteogenic differentiation of stromal cells derived from human adipose tissue ( hADSC ) and the *role* of activation on [TNF-alpha] activity . Regulation TNF NFKB1 20220144 2249415 We demonstrated previously that the gene encoding NGAL ( LCN2 ) is strongly up-regulated by interleukin (IL)-1beta in an *dependent* manner but not by [tumor necrosis factor (TNF)-alpha] , another potent activator of NF-kappaB . Regulation TNF NFKB1 20356387 2255200 Moreover , we explored the mechanism governing the expression of ATX in hepatoma cells and established a critical *role* of in basal and [TNF-alpha] induced ATX expression . Regulation TNF NFKB1 2555174 120828 This strongly suggests that induction of an activity is *responsible* for [TNF-alpha] stimulation of mouse MHC class I genes . Regulation TNF NFKB1 7608567 311960 These results indicate that superantigen induces NF-kappa B in human monocytic cells and suggest that binding of to the kappa 3 site of the TNF-alpha promoter *plays* an important role in the transcriptional activation of the [TNF-alpha] gene by superantigen . Regulation TNF NFKB1 7635431 317123 Using primary cultures of rat Kupffer cells the *role* of and activator protein 1 (AP-1) in the expression of the [tumor necrosis factor-alpha (TNF-alpha)] gene by lipopolysaccharide (LPS) was investigated . Regulation TNF NFKB1 7635431 317127 The results indicate a direct *participation* of in the regulation of [TNF-alpha] synthesis and a differential effect of LPS on NF-kappa B and AP-1 , respectively . Regulation TNF NFKB1 7913275 262073 HIV-1 expression was activated from J delta K cells by treatment with phorbol myristate acetate ( PMA ) , sodium butyrate ( NaB ) , or hexamethylene bisacetamide ( HMBA ) , but not tumor necrosis factor alpha (TNF-alpha) , confirming the *role* of in mediating [TNF-alpha] induction of HIV transcription . Regulation TNF NFKB1 8632999 361584 CNI-1493 blocked neither the lipopolysaccharide (LPS) induced increases in the expression of TNF mRNA nor the translocation of nuclear factor NF-kappa B to the nucleus in macrophages activated by 15 min of LPS stimulation , indicating that CNI-1493 does not interfere with early transcriptional *regulation* of [TNF] . Regulation TNF NFKB1 8798400 381446 These results indicate that TNF-alpha induced [TNF-alpha] gene expression in astrocytes *involves* p50 and p65 proteins binding to downstream NF-kappaB sites and concomitant modulation of the chromatin structure . Regulation TNF NFKB1 8849369 359036 Our results suggest that *plays* a pivotal role in synovial cell activation by [TNFalpha] . Regulation TNF NFKB1 8900181 393440 Synergistic activation of interleukin-8 gene transcription by all-trans-retinoic acid and [tumor necrosis factor-alpha] *involves* the transcription factor . Regulation TNF NFKB1 9079634 420547 *Role* of in [tumor necrosis factor-alpha] and interleukin-1beta regulation . Regulation TNF NFKB1 9366558 466091 Transcriptional control of the [TNF alpha] gene is *regulated* by the . Regulation TNF NFKB1 9486215 488324 In the present study , electrophoretic mobility shift assays ( EM-SAs ) and pyrrolidine dithiocarbamate ( PDTC ) , an inhibitor of NF-kappa B activation , were utilized to determine the *role* of activation in TPA and [TNF-alpha] inhibition of the surfactant proteins in NCI-H441 cells . Regulation TNF NFKB1 9581775 503483 The protective *role* of in blocking [TNFalpha-] and HIV-1 induced apoptosis was supported by studies in Jurkat T cells engineered to express IkappaB alpha repressor mutants ( TD-IkappaB ) under the control of a tetracycline-responsive promoter . Regulation TNF NFKB1 9603479 506809 IL-10 mediated suppression of [TNF-alpha] production is *independent* of its ability to inhibit activity . Regulation TNF NFKB1 9794408 542964 Our results demonstrate that a novel nuclear binding activity *plays* an important role in regulation of the rapid and transient transcriptional activation of the [TNF-alpha] gene via Fc epsilonRI . Regulation TNF NFKB1 9868178 556541 We postulated that green tea polyphenols *regulate* [TNFalpha] gene expression by modulating activation through their antioxidant properties . Regulation TNF NFKB1 9916895 559061 We determined that binding sites for both ( -186 bp region ) and C/EBP ( -198 bp region ) are *involved* in [TNF-alpha] and IL-1beta mediated ICAM-1 upregulation . Regulation TNF NFKBIA 10947072 721894 Lipopolysaccharide triggered desensitization of [TNF-alpha] mRNA expression *involves* lack of phosphorylation of in a murine macrophage-like cell line , P388D1 . Regulation TNF NFKBIA 12578813 1058230 This study examined the *effects* of either overexpression ( transgenic mice ) or N-acetyl-leucinyl-leucinyl-norleucinal ( ALLN ) administration ( proteosome inhibitor in wild-type mice ) on cardiomyocyte secretion of [tumor necrosis factor-alpha (TNF-alpha)] and on cardiac performance after burn trauma . Regulation TNF NFKBIA 15629094 1362134 The *effect* of expressed and CTLA4Ig on the expression of [TNF-alpha] of ECV304 cells stimulated with LPS was also investigated . Regulation TNF NFKBIA 19647754 2182947 By acting downstream of NF-kappaB to inhibit I kappaB alpha gene induction by TNF-alpha , PACAP may block *dependent* negative autoregulation of [TNF-alpha] signaling through NF-kappaB , prolonging TNF-alpha dependent signaling to neuropeptide encoding genes in chromaffin cells . Regulation TNF NFKBIA 20663042 2298146 These results indicated that the downregulation of [TNF-alpha] by S. tenuifolia water extract may have *involved* the inhibition of both degradation and activation of c-Jun and ATF-2 involving suppression of JNK/SAPK . Regulation TNF NFKBIA 7642544 317973 *Involvement* of a putative protein-tyrosine phosphatase and serine phosphorylation in nuclear factor kappa B activation by [tumor necrosis factor] . Regulation TNF NGF 11404390 825442 *regulates* [TNF-alpha] production in mouse macrophages via MAP kinase activation . Regulation TNF NGF 15902903 1353129 Because NGF has been reported to affect the synthesis of proinflammatory cytokines , we also evaluated whether the production of [tumor necrosis factor-alpha] would be *affected* by ethanol mediated changes in synthesis . Regulation TNF NLN 12108020 963137 The production of [TNF-alpha] and IL-1 beta was not *affected* by and GLP at the concentrations which significantly inhibited the proliferative activity and T cell derived cytokine production . Regulation TNF NLRP3 22711073 2621318 *Role* of and CARD8 in the regulation of [TNF-a] induced IL-1ß release in vascular smooth muscle cells . Regulation TNF NOD2 17709422 1806108 Mycolylarabinogalactan peptidoglycan ( PGN ) , the cell wall core of M. tuberculosis , stimulated macrophages to release [tumor necrosis factor (TNF)] and interleukin-12p40 in a partially *dependent* manner , and M. tuberculosis PGN required NOD2 for the optimal induction of TNF . Regulation TNF NOD2 19094116 2036076 CD patients have impaired GM-CSF secretion via NOD2 dependent and -independent pathways and display an impaired *dependent* down-regulation of [TNF-alpha] secretion . Regulation TNF NOD2 22752913 2622982 ELISA showed that the production of IL-6 and [TNF-a] in BMDMs infected with Y. enterocolitica was not *affected* by the deficiency . Regulation TNF NOD2 24611904 2933911 Based on recent evidence that XIAP is essential for nucleotide binding and oligomerization domains ( NOD)1/2 signalling , we evaluated the use of a simple flow cytometric assay assessing [tumour necrosis factor (TNF)] production of monocytes in *response* to stimulation by muramyl dipeptides ( L18-MDP ) for the functional diagnosis of XIAP deficiency . Regulation TNF NOS1 10374159 623056 These findings suggest a strong inhibitory *effect* of inhibitors and corticosteroids on aqueous levels of [TNF-alpha] and NO and no inhibitory effect on IL-1 beta and IL-6 levels after cataract surgery . Regulation TNF NOS1 11414678 828988 The ability of Japanese encephalitis virus ( JEV ) and JEV induced macrophage derived factor ( MDF ) to modulate nitric oxide synthase (NOS) activity in brain and [tumor necrosis factor-alpha (TNF-alpha)] and the possible antiviral *role* of during JEV infection were investigated . Regulation TNF NOS1 11571673 864397 Here we evaluated the *effect* of inhibitors on the bone particle resorbing activity and [TNF-alpha] release of cultured peripheral blood monocytes ( PBM ) obtained from 10 premenopausal ( PreM ) and 10 postmenopausal ( PostM ) women . Regulation TNF NOS1 15501965 1327224 We investigated the *role* of endothelial in determining the tumor-selective activity of [TNF] . Regulation TNF NOS1 17466955 1761300 *Role* of neuronal in lipopolysaccharide induced [tumor necrosis factor-alpha] expression in neonatal mouse cardiomyocytes . Regulation TNF NOS1 17466955 1761305 However , the *role* of in LPS induced [TNF-alpha] expression is not known . Regulation TNF NOS1 23176791 2704136 The anti-IBD effects of phytochemicals were associated with *modulating* the levels of [tumor necrosis factor a (TNF-a)] , interleukin (IL)-1 , IL-6 , inducible , and myeloperoxide . Regulation TNF NOS2 10705297 673079 Immunohistochemical staining for iNOS and determination of iNOS activity indicated that expression was mainly upregulated in the small intestine , lung and heart , and that IFN-gamma , [TNF-alpha] as well as IL-10 are *involved* in the regulation of iNOS expression and enzyme activity . Regulation TNF NOS2 10748117 690865 Experiments with HO-1/KO and iNOS/KO mice showed that Allotrap 1258 mediated inhibition of [TNF] was *independent* of HO-1 and . Regulation TNF NOS2 15501965 1327225 We investigated the *role* of endothelial in determining the tumor-selective activity of [TNF] . Regulation TNF NOS2 17466955 1761301 *Role* of neuronal in lipopolysaccharide induced [tumor necrosis factor-alpha] expression in neonatal mouse cardiomyocytes . Regulation TNF NOS2 19778597 2163671 Aqueous extract of Vitex trifolia leaves showed significant dose- and time dependent inhibitory activity on interleukin (IL)-1 beta , IL-6 and mRNA synthesis , but slight *effect* on [tumor necrosis factor (TNF)-alpha] , all of which are involved in the inflammatory response . Regulation TNF NOS2 20830678 2346335 From these results , we suggest that fucoidan affects not only IFN-? induced production differently in brain and peritoneal macrophages due to the different roles of p38 but the *effects* on [TNF-a] production in the two cell types . Regulation TNF NOS2 23176791 2704137 The anti-IBD effects of phytochemicals were associated with *modulating* the levels of [tumor necrosis factor a (TNF-a)] , interleukin (IL)-1 , IL-6 , inducible , and myeloperoxide . Regulation TNF NOS3 10747895 690601 Here we show that *regulates* [tumor necrosis factor alpha (TNFalpha)] through a mechanism dependent on the production of O ( 2 ) and completely independent of NO . Regulation TNF NOS3 12506117 1056950 The purpose of this study was to investigate the *role* of , cAMP , and p38 MAPK in [tumor necrosis factor-alpha (TNF-alpha)] expression induced by lipopolysaccharide (LPS) . Regulation TNF NOS3 15501965 1327226 We investigated the *role* of endothelial in determining the tumor-selective activity of [TNF] . Regulation TNF NOS3 17466955 1761302 *Role* of neuronal in lipopolysaccharide induced [tumor necrosis factor-alpha] expression in neonatal mouse cardiomyocytes . Regulation TNF NOS3 23176791 2704138 The anti-IBD effects of phytochemicals were associated with *modulating* the levels of [tumor necrosis factor a (TNF-a)] , interleukin (IL)-1 , IL-6 , inducible , and myeloperoxide . Regulation TNF NOX1 12572857 1029579 *Effect* of inhibition on E-selectin expression induced by concomitant anoxia/reoxygenation and [TNF-alpha] . Regulation TNF NOX1 14967724 1212165 Cilostazol ( 1 to 100 micromol/L ) significantly suppressed not only *dependent* superoxide production but also [TNF-alpha] and interleukin-1beta release and restored viability . Regulation TNF NOX1 23639811 2805076 Cumulatively , these results demonstrate that NOX2 and its activator subunits ( p47phox and Rac ) control the secretion of TNF-a by the liver following I/R. Interestingly , in the absence of Kupffer cells and NOX2 , *played* a dominant role in [TNF-a] production following hepatic I/R . Regulation TNF NOX1 23639811 2805085 Thus Kupffer cell derived factors and NOX2 act to suppress hepatic *dependent* [TNF-a] production . Regulation TNF NOX3 12572857 1029580 *Effect* of inhibition on E-selectin expression induced by concomitant anoxia/reoxygenation and [TNF-alpha] . Regulation TNF NOX3 14967724 1212166 Cilostazol ( 1 to 100 micromol/L ) significantly suppressed not only *dependent* superoxide production but also [TNF-alpha] and interleukin-1beta release and restored viability . Regulation TNF NOX4 12572857 1029581 *Effect* of inhibition on E-selectin expression induced by concomitant anoxia/reoxygenation and [TNF-alpha] . Regulation TNF NOX4 14967724 1212167 Cilostazol ( 1 to 100 micromol/L ) significantly suppressed not only *dependent* superoxide production but also [TNF-alpha] and interleukin-1beta release and restored viability . Regulation TNF NOX5 12572857 1029578 *Effect* of inhibition on E-selectin expression induced by concomitant anoxia/reoxygenation and [TNF-alpha] . Regulation TNF NOX5 14967724 1212164 Cilostazol ( 1 to 100 micromol/L ) significantly suppressed not only *dependent* superoxide production but also [TNF-alpha] and interleukin-1beta release and restored viability . Regulation TNF NPEPPS 21864268 2505692 [Tumor necrosis factor] was the first successful *target* of cytokine inhibition therapy for psoriasis and ( e.g. , infliximab , adalimumab , and etanercept ) . Regulation TNF NPTX1 24195381 2864365 We studied the regulating *effect* of human bocavirus 1 ( HBoV1 ) nonstructural protein on the activity of cellular transcription factors and the expression of inflammatory cytokine [TNF-alpha] and IL-6 . Regulation TNF NPY 16005734 1431288 The present work deals with the in vitro *effects* of norepinephrine and , separately and jointly , on functions such as lymphoproliferation , NK activity , and IL-2 and [TNF-alpha] release of peritoneal leucocytes from adult ( 24+/-2 weeks ) , old ( 72+/-2 weeks ) and very old ( 128+/-2 weeks ) mice . Regulation TNF NPY 23623189 2795459 In the present work , we have evaluated the *effects* of on the release of [TNF-a] , IL-1ß , IL-6 and HMGB1 mediators in peritoneal macrophages . Regulation TNF NPY6R 17934341 1813469 On the other hand , , a c-Src specific inhibitor , did not *affect* TCDD induced [TNF-alpha] expression . Regulation TNF NPY6R 24470356 2913217 It is also presented that pannexin-1 hemichannel function and potential heterodimers are not *involved* in P2X7 dependent release of IL-6 , CCL2 , and [TNF-a] in microglia . Regulation TNF NQO1 16682409 1584039 Although overexpressed in tumor cells , the NQO1 has been linked with the suppression of carcinogenesis , and the *effect* of on [tumor necrosis factor (TNF)] , a cytokine that mediates tumorigenesis through proliferation , invasion , angiogenesis , and metastasis of tumors , is currently unknown . Regulation TNF NQO1 16682409 1584042 The purpose of our study was to determine the *role* of in [TNF] cell signaling by using keratinocytes derived from wild-type and NQO1 gene deleted mice . Regulation TNF NR4A1 19213954 2050044 These results indicate that negatively *regulates* the [TNF-alpha-] and interleukin-1beta induced vascular EC activation by transcriptionally upregulation of IkappaBalpha expression . Regulation TNF NUP43 12775717 1119749 Mechanistic studies indicated that , in comparison with PAR1 signaling , prolonged increase of [ Ca2+ ] i and phosphorylation of mitogen activated protein kinases , as well as NFkappaB activation may be *responsible* for PAR4AP induced [TNF-alpha] production in microglia . Regulation TNF NUP43 19303658 2064327 In contrast , RAGE stimulated Egr-1 independent pathways *regulate* [TNF-alpha] production and apoptosis in response to I/R. Consistent with these findings , and phospho-JNK MAPK and c-Jun were strikingly suppressed in RAGE ( -/- ) versus WT mice , but not in Egr-1 ( -/- ) mice . Regulation TNF OAS1 8551280 339935 These results suggest that [tumor necrosis factor-alpha] and interferon-gamma inhibit hepatitis B virus replication by blocking some step in reverse transcription and that the <2',5'-oligoadenylate synthetase> is not *involved* in the mechanism underlying the inhibition by these two cytokines . Regulation TNF OAS2 8551280 339936 These results suggest that [tumor necrosis factor-alpha] and interferon-gamma inhibit hepatitis B virus replication by blocking some step in reverse transcription and that the <2',5'-oligoadenylate synthetase> is not *involved* in the mechanism underlying the inhibition by these two cytokines . Regulation TNF OAS3 8551280 339937 These results suggest that [tumor necrosis factor-alpha] and interferon-gamma inhibit hepatitis B virus replication by blocking some step in reverse transcription and that the <2',5'-oligoadenylate synthetase> is not *involved* in the mechanism underlying the inhibition by these two cytokines . Regulation TNF OLR1 19118493 2019356 AGEs ( advanced glycation end-products ) /RAGE ( receptor for AGEs ) , [ lectin-like oxidized low-density lipoprotein receptor-1 ) and NF-kappaB ( nuclear factor kappaB ) signalling *play* key roles in [TNF-alpha] expression through an increase in circulating and/or local vascular TNF-alpha production . Regulation TNF OLR1 21471194 2433543 Finally , we examined the effect of ONL on the expression of the inflammation associated gene in THP-1 and observed that the ONL coupled proteins significantly induced the expression of atherogenesis related genes , such as the monocyte chemoattractant protein-1 and [tumor necrosis factor-a] , in a *dependent* manner . Regulation TNF OMP 12414158 1011001 It is likely that the induced *effect* on [TNF-alpha] production assists bacterial evasion of antimicrobial defences at different levels . Regulation TNF OMP 17635859 1793058 In light of these data , we propose a model in which virulent Brucella alters the maturation and functions of DCs through *dependent* control of [TNF-alpha] production . Regulation TNF OMP 8239920 236131 The *effect* of on the release of [TNF] and IL-6 was dose and time dependent , maximal production being reached at 10 micrograms of OMP after 20 h . Regulation TNF OPN1MW 19596476 2117935 The *effects* of on cognition , locomotion and on [TNF-alpha] receptor 1 expression were blocked by ZM241385 , an A ( 2 ) A adenosine receptor antagonist . Regulation TNF OPRM1 18349186 1887044 The was not *involved* in this morphine induced [TNF] inhibition in PBMCs . Regulation TNF OPTN 17702576 1782965 negatively *regulates* [TNFalpha-] induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP . Regulation TNF OXA1L 9293394 452858 Similar induction of the synthesis and secretion of [TNF-alpha] and chemotaxis by monocytes in *response* to in vivo may contribute to atherosclerosis in macro- and micro-angiopathy , particularly in the development of chronic clinical complications of diabetes mellitus . Regulation TNF OXT 23183119 2736222 In another set of animals we studied the *effect* of on nitrite , [tumor necrosis factor] ( TNF-a ) , interleukin (IL)-1ß and IL-10 production of peritoneal macrophages harvested at 6 and 24 h after CLP . Regulation TNF P2RX4 24470356 2913218 It is also presented that pannexin-1 hemichannel function and potential heterodimers are not *involved* in P2X7 dependent release of IL-6 , CCL2 , and [TNF-a] in microglia . Regulation TNF P2RX7 21044631 2389561 Absence of the receptor did not *affect* IFN-? , IL-12 , IL-1ß , monocyte chemoattractant protein-1 ( MCP-1 ) or [TNF] production . Regulation TNF P2RX7 24470356 2913219 It is also presented that pannexin-1 hemichannel function and potential P2X4/P2X7 heterodimers are not involved in *dependent* release of IL-6 , CCL2 , and [TNF-a] in microglia . Regulation TNF P4HB 18475579 290007 The present study was performed to examine whether residues 36-62 of TNFalpha contain the chemotactic domain of TNFalpha , and whether the and p75 TNF receptors are *involved* in [TNFalpha] induced chemotaxis . Regulation TNF P4HB 18680601 1979517 Downregulation of in sepsis and its *role* in [tumor necrosis factor-alpha] release . Regulation TNF P4HB 9551933 499124 In summary , these data help clarify the biologic *roles* of and p75 in mediating and modulating the biologic activity of [TNF] and provide genetic evidence for an antagonistic role of p75 in vivo . Regulation TNF PABPC1 11116146 786608 NF-kappaB activation by the [tumor necrosis factor receptor (TNFR)] *involves* the formation of a termed a signalosome . Regulation TNF PAF1 12381675 997381 The lipid mediator *plays* an important role in the phagocytosis of particles , including bacteria , and consequent production of pro-inflammatory cytokines , such as [TNF-alpha] and IL-8 . Regulation TNF PAF1 15316260 1286202 The aim of this study was to determine [tumor necrosis factor alpha (TNF-alpha)] and interleukin-6 (IL-6) release in *response* to induction in peripheral blood mononuclear cells ( PBMCs ) from chronic hepatitis B virus ( HBV ) carriers . Regulation TNF PAF1 15316260 1286222 Compared with group A , PBMCs from naturally immune subjects and chronic HBV carriers produced significantly higher amounts of [TNF-alpha] and IL-6 in *response* to . Regulation TNF PAF1 1613396 191115 Moreover , 6 day- or 7 day differentiated HL-60 cells showed a further increase in [TNF] production in *response* to , and the response was bimodal , similar to that of the less dense subset of monocytes , with peaks at 10 ( -14 ) and 10 ( -7 ) M PAF . Regulation TNF PAF1 1668107 176694 The *effect* of and of two specific PAF antagonists on [tumor necrosis factor (TNF)] induced superoxide production by human polymorphonuclear neutrophils ( PMN ) was examined . Regulation TNF PAF1 1873355 165252 Further , the *role* of released in response to a challenge with LPS in the regulation of [TNF] and IL-6 production was investigated . Regulation TNF PAF1 1873355 165262 *played* a central role in the [TNF] release in the in vitro experiments . Regulation TNF PAF1 2545780 114301 The *effect* of on [TNF] production by rat alveolar macrophages ( AM ) and the role of endogenous leukotriene B4 (LTB4) in this regulation were examined . Regulation TNF PAF1 7821968 285559 In the present study we investigated the *effects* of endotoxin and on [TNF] gene expression . Regulation TNF PAF1 8009983 243908 The results showed that might *play* an important role in the production of [TNF] . Regulation TNF PAF1 8423096 210791 It was concluded that *plays* an important role in endotoxin induced [TNF] production and mortality . Regulation TNF PAF1 8653713 364652 The effect of platelet activating factor (PAF) on experimental pulmonary metastasis by the B16F10 murine melanoma and the possible *involvement* of in the activities of [tumor necrosis factor alpha (TNF-alpha)] and interleukin 1alpha (IL-1alpha) in tumor metastasis were investigated . Regulation TNF PAIP1 11116146 786605 NF-kappaB activation by the [tumor necrosis factor receptor (TNFR)] *involves* the formation of a termed a signalosome . Regulation TNF PAM 11673494 872774 Thus , the IFN-beta gene is an early response gene that is activated in *response* to via a pathway that involves reactive oxygen species , and IFN-beta in turn plays an important role in L-PAM induced [TNF-alpha] up-regulation . Regulation TNF PAM 16850005 1600377 In sepsis , [tumor necrosis factor] production in *response* to lipopolysaccharide and was reduced , whereas interleukin-10 production was enhanced . Regulation TNF PAM 16850005 1600379 Monocytes from RCA patients showed a reduced production of [tumor necrosis factor] in *response* to lipopolysaccharide but neither to nor to heat killed bacteria . Regulation TNF PAM 17690330 1842485 Moreover , inhibition of PKR phosphorylation severely impaired [TNF-alpha] and IL-6 production by AM in *response* to LPS and . Regulation TNF PAM 22525195 2595813 Ciclosporin alone did not alter the expression levels of these transcripts but in the presence of ciclosporin , TNF-a mRNA expression was upregulated in response to all three agonists and both [TNF-a] and IL-8 transcript abundance was increased in *response* to . Regulation TNF PAM 23002100 2720175 We demonstrated an increased WLL cell influx , increased IL-6 and chemokine KC ( Cxcl1 ) , and decreased macrophage inflammatory protein (MIP)-1a and [TNF-a] in *response* to as a result of ozone pre-exposure . Regulation TNF PANX1 24470356 2913220 It is also presented that hemichannel function and potential P2X4/P2X7 heterodimers are not *involved* in P2X7 dependent release of IL-6 , CCL2 , and [TNF-a] in microglia . Regulation TNF PAPSS1 16269668 1502357 Inhibition of N-SMase2 inhibited Sph1P formation , whereas inhibition of did not *affect* N-SMase2 activation by [TNF-alpha] . Regulation TNF PARP1 14762203 1207164 Transcription *regulation* of [TNF-alpha-early] response genes by in murine heart endothelial cells . Regulation TNF PARP1 18996291 1983894 MNCs from healthy subjects were cultured to investigate the direct *effects* of on NF-kappaB DNA binding activity and the expression of [TNF-alpha] and IL-6 . Regulation TNF PARP1 19454727 2084612 also *regulated* [TNF-alpha] expression and up-regulation of adhesion molecules , further supporting a role of PARP-1 in the inflammatory process within the kidney . Regulation TNF PARP1 23357477 2758606 However , activity had no *effect* on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Regulation TNF PARP1 9639400 514061 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Regulation TNF PARP10 23357477 2758601 However , activity had no *effect* on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Regulation TNF PARP10 9639400 514056 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Regulation TNF PARP11 23357477 2758598 However , activity had no *effect* on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Regulation TNF PARP11 9639400 514053 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Regulation TNF PARP12 23357477 2758599 However , activity had no *effect* on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Regulation TNF PARP12 9639400 514054 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Regulation TNF PARP14 23357477 2758610 However , activity had no *effect* on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Regulation TNF PARP14 9639400 514065 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Regulation TNF PARP15 23357477 2758604 However , activity had no *effect* on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Regulation TNF PARP15 9639400 514059 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Regulation TNF PARP16 23357477 2758602 However , activity had no *effect* on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Regulation TNF PARP16 9639400 514057 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Regulation TNF PARP2 23357477 2758608 However , activity had no *effect* on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Regulation TNF PARP2 9639400 514063 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Regulation TNF PARP3 23357477 2758609 However , activity had no *effect* on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Regulation TNF PARP3 9639400 514064 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Regulation TNF PARP4 23357477 2758607 However , activity had no *effect* on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Regulation TNF PARP4 9639400 514062 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Regulation TNF PARP6 23357477 2758605 However , activity had no *effect* on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Regulation TNF PARP6 9639400 514060 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Regulation TNF PARP8 23357477 2758603 However , activity had no *effect* on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Regulation TNF PARP8 9639400 514058 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Regulation TNF PARP9 23357477 2758600 However , activity had no *effect* on the mRNA level of COX-2 , [TNF-a] and NADPH oxidase in the hippocampus . Regulation TNF PARP9 9639400 514055 Moreover , it was demonstrated that combining TNF with the poly-ADP-ribose polymerase (PARP) inhibitors 6-aminonicotinamide and 3-aminobenzamide did not affect TNF-sensitivity in GLC4 and GLC4-Adr350x , excluding a pivotal *role* of in [TNF-resistance] in these cell lines . Regulation TNF PDCD1 24398264 2906893 In addition , previous studies have shown that [TNF-a] is *involved* in cellular differentiation , neurogenesis and during the development of the central nervous system . Regulation TNF PDCD10 24398264 2906894 In addition , previous studies have shown that [TNF-a] is *involved* in cellular differentiation , neurogenesis and during the development of the central nervous system . Regulation TNF PDCD11 24398264 2906892 In addition , previous studies have shown that [TNF-a] is *involved* in cellular differentiation , neurogenesis and during the development of the central nervous system . Regulation TNF PDCD2 24398264 2906895 In addition , previous studies have shown that [TNF-a] is *involved* in cellular differentiation , neurogenesis and during the development of the central nervous system . Regulation TNF PDCD4 24398264 2906896 In addition , previous studies have shown that [TNF-a] is *involved* in cellular differentiation , neurogenesis and during the development of the central nervous system . Regulation TNF PDCD5 24398264 2906897 In addition , previous studies have shown that [TNF-a] is *involved* in cellular differentiation , neurogenesis and during the development of the central nervous system . Regulation TNF PDCD6 24398264 2906898 In addition , previous studies have shown that [TNF-a] is *involved* in cellular differentiation , neurogenesis and during the development of the central nervous system . Regulation TNF PDCD7 24398264 2906899 In addition , previous studies have shown that [TNF-a] is *involved* in cellular differentiation , neurogenesis and during the development of the central nervous system . Regulation TNF PDE3A 18475493 209553 The *effect* of selective PDE-I ( vinpocetine ) , ( milrinone , CI-930 ) , PDE-IV ( rolipram , nitroquazone ) , and PDE-V ( zaprinast ) isozyme inhibitors on [TNF-alpha] and IL-1beta production from LPS stimulated human monocytes was investigated . Regulation TNF PDE3B 18475493 209554 The *effect* of selective PDE-I ( vinpocetine ) , ( milrinone , CI-930 ) , PDE-IV ( rolipram , nitroquazone ) , and PDE-V ( zaprinast ) isozyme inhibitors on [TNF-alpha] and IL-1beta production from LPS stimulated human monocytes was investigated . Regulation TNF PDE4B 18687753 1973597 These findings strongly support the pathogenic *role* of in the ethanol mediated priming of monocytes/macrophages and increased LPS-inducible [TNF] production and the subsequent development of alcoholic liver disease (ALD) . Regulation TNF PDE7A 19379723 2081945 These results demonstrate that might *regulate* [TNF-alpha] production in keratinocytes in a cAMP dependent fashion . Regulation TNF PDIA3 22207023 2549740 This is the first study , which reports the *role* of and hnRNP-H in [TNF-a] production in DENV infected cells . Regulation TNF PECAM1 18025177 1827647 In this study , we demonstrate that ligation with CD38-Fc fusion protein negatively *regulates* LPS induced proinflammatory cytokine [TNF-alpha] , IL-6 , and IFN-beta production by inhibiting JNK , NF-kappaB , and IFN regulatory factor 3 activation in macrophages . Regulation TNF PEX19 11521058 766178 The *effect* of , nimesulide ( NIM ) , indomethacin (INDO) and dexamethasone ( DEX ) on the regulation of PGE2 and [TNF-alpha] production was tested . Regulation TNF PGD 8931117 397840 To investigate possible mechanisms for this we determined *effects* of , PGJ2 and two PGJ2 metabolites delta 12-PGJ2 and 15-deoxy-delta 12 , delta 14 PGJ2 on [tumor necrosis factor-alpha (TNF-alpha)] release from blood monocytes in vitro . Regulation TNF PGLYRP3 21176858 2419446 Overexpression of in Caco2 cells down *regulated* the expression of the inflammatory cytokines IL-8 , IL-12 and [TNF-a] , while its silencing increased the expression of these cytokines . Regulation TNF PHB 19710421 2144798 We examined the effect of tumor necrosis factor alpha (TNF-alpha) , a cytokine that plays a central role in the pathogenesis of IBD , on expression and the *effect* of sustained PHB expression on [TNF-alpha] activation of nuclear factor-kappa B (NF-kappaB) and epithelial barrier dysfunction , two hallmarks of intestinal inflammation . Regulation TNF PHIP 18845389 2012988 Here , we investigated the *effect* of on [tumor necrosis factor-alpha (TNF-alpha)] expression by murine macrophage-like cells ( RAW 264.7 ) stimulated with lipoteichoic acid (LTA) , a major virulence factor of Gram positive bacteria . Regulation TNF PI3 12055072 951592 A *role* for PKC-delta and in [TNF-alpha] mediated antiapoptotic signaling in the human neutrophil . Regulation TNF PI3 12055072 951604 In this study , a *role* for PKC-delta and in [TNF-alpha] mediated antiapoptotic signaling was examined . Regulation TNF PI3 15115707 1279378 These results suggest that delta-PKC and *regulate* [TNF] antiapoptotic signaling at the level of the TNFR-1 through control of assembly of a TNFR-1-TRADD-RIP-TRAF2 complex . Regulation TNF PI3 16081599 1460401 These results indicate that gp120 elicited [TNF-alpha] production by macrophages *involves* chemokine receptor mediated and MAPK activation , that PI-3K is an upstream regulator of MAPK in this pathway , and that p38 and ERK-1/2 independently regulate TNF-alpha production . Regulation TNF PI3 18207479 1876669 [TNFalpha] signaling *involves* kinase B (PKB) , and p44/42 MAP kinase (MAPK) which are important in NF-kappaB activation . Regulation TNF PIK3CA 10464169 640319 Therefore , both and p38 MAPK signaling pathways *control* [TNF-alpha] production in T cells . Regulation TNF PIK3CA 10559228 566468 CD45 induced [tumor necrosis factor] alpha production in monocytes is *dependent* and nuclear factor-kappaB independent . Regulation TNF PIK3CA 11328375 807936 The increase in translation of TNF-alpha due to serum could be inhibited by the phosphatidylinositol (PI) 3-K inhibitors , wortmannin and LY294002 , suggesting that is *involved* in the translational control of [TNF-alpha] by serum . Regulation TNF PIK3CA 19180470 2033005 The limiting *effect* of on [TNF-alpha] production from activated monocytes depended on the decrease of GSK-3beta activity , which significantly reduced the transactivation of NF-kappaB . Regulation TNF PIK3CA 21209364 2402358 While investigating the different actors of signalization , we found that p38 kinase and were playing an important *role* in HKSA phagocytosis and [TNF] production . Regulation TNF PIK3CA 21637390 2437151 Both [TNF-a] and IL-6 production by HBHA was *regulated* by the NF-?B , , and MAPK pathways . Regulation TNF PIK3R1 10464169 640320 Therefore , both and p38 MAPK signaling pathways *control* [TNF-alpha] production in T cells . Regulation TNF PIK3R1 10559228 566469 CD45 induced [tumor necrosis factor] alpha production in monocytes is *dependent* and nuclear factor-kappaB independent . Regulation TNF PIK3R1 11328375 807937 The increase in translation of TNF-alpha due to serum could be inhibited by the phosphatidylinositol (PI) 3-K inhibitors , wortmannin and LY294002 , suggesting that is *involved* in the translational control of [TNF-alpha] by serum . Regulation TNF PIK3R1 19180470 2033006 The limiting *effect* of on [TNF-alpha] production from activated monocytes depended on the decrease of GSK-3beta activity , which significantly reduced the transactivation of NF-kappaB . Regulation TNF PIK3R1 21209364 2402359 While investigating the different actors of signalization , we found that p38 kinase and were playing an important *role* in HKSA phagocytosis and [TNF] production . Regulation TNF PIK3R1 21637390 2437152 Both [TNF-a] and IL-6 production by HBHA was *regulated* by the NF-?B , , and MAPK pathways . Regulation TNF PKN1 18435913 1908197 SiRNA of Pkn1 , a Rho-GTPase effecter protein kinase , suppressed TNFalpha levels as well as Pkn1 expression , suggesting that is *involved* in [TNFalpha] signaling . Regulation TNF PLA2G1B 18191813 1876145 To find out the mechanisms underlying the TNFalpha induced release of AA , we investigated the relationship between [TNFalpha] stimulation and *regulation* with and without zVAD , an inhibitor of caspases . Regulation TNF PLA2G1B 7540278 307218 These data suggest an *involvement* of in both [TNF-] and Fas mediated cytotoxicity and a novel mechanism of action for bcl-2 and bcl-x , i.e. inhibition of arachidonic acid metabolism , by which they may , in addition of apoptosis , modulate inflammation . Regulation TNF PLA2G1B 8762444 343595 Those results indicated that activation was *involved* in the [TNF] stimulated enhancement of neutrophil chemotaxis and adhesion . Regulation TNF PLA2G4A 10501211 648485 Signaling mechanisms *involved* in the activation of arachidonic acid metabolism in human astrocytoma cells by [tumor necrosis factor-alpha] : phosphorylation of and transactivation of cyclooxygenase-2 . Regulation TNF PLA2G4A 11390371 842555 We have previously shown that both secretory and ( PLA(2) ) are *involved* in [TNF-alpha-] and IL-1beta induced NF-kappaB activation . Regulation TNF PLA2R1 11201160 785426 In addition , the elevated expression level of TNF-alpha transcript was significantly reduced by the deficiency of PLA2R , suggesting that *plays* a role in the regulation of [TNF-alpha] expression in these cell types . Regulation TNF PLCG1 18079103 1874535 The purpose of this study was to investigate the *role* of phosphatidylinositol ( PI ) ( PLCgamma1 ) in cardiac [TNF-alpha] expression , and myocardial dysfunction during endotoxemia . Regulation TNF PLD1 24548427 2915096 The purpose of this study was to identify the *role* of in lipopolysaccharide (LPS) induced [tumor necrosis factor-a (TNF-a)] expression and production . Regulation TNF PLD1 24548427 2915113 To investigate the *role* of in LPS induced [TNF-a] expression and production , we transfected PLD1 and PLD2 siRNAs to Raw 264.7 cells , respectively . Regulation TNF PLD2 24548427 2915114 To investigate the *role* of in LPS induced [TNF-a] expression and production , we transfected PLD1 and PLD2 siRNAs to Raw 264.7 cells , respectively . Regulation TNF PLD3 24548427 2915109 To investigate the *role* of in LPS induced [TNF-a] expression and production , we transfected PLD1 and PLD2 siRNAs to Raw 264.7 cells , respectively . Regulation TNF PLD4 24548427 2915110 To investigate the *role* of in LPS induced [TNF-a] expression and production , we transfected PLD1 and PLD2 siRNAs to Raw 264.7 cells , respectively . Regulation TNF PLD5 24548427 2915111 To investigate the *role* of in LPS induced [TNF-a] expression and production , we transfected PLD1 and PLD2 siRNAs to Raw 264.7 cells , respectively . Regulation TNF PLD6 24548427 2915112 To investigate the *role* of in LPS induced [TNF-a] expression and production , we transfected PLD1 and PLD2 siRNAs to Raw 264.7 cells , respectively . Regulation TNF PLIN1 9733764 531019 These results provide the first evidence of how perilipin functions and suggest that [TNF-alpha] *regulates* lipolysis , in part , by decreasing protein levels at the lipid droplet surface . Regulation TNF PLIN2 19851831 2217013 *affects* the expression of [TNF-alpha] , MCP-1 , and IL-6 in THP-1 macrophages . Regulation TNF PLK1 24205328 2864785 is *involved* in toll-like receptor (TLR) mediated [TNF-a] production in monocytic THP-1 cells . Regulation TNF PLK1 24205328 2864793 Moreover , western blot results showed that TLRs activated PLK1 , and PLK1 inhibition by RNA interference down-regulated Pam3CSK4 induced TNF-a production , suggesting the *involvement* of in [TNF-a] up-regulation . Regulation TNF PMEL 12709443 1100425 RelB/p50 dimers are differentially *regulated* by [tumor necrosis factor-alpha] and lymphotoxin-beta receptor activation : critical roles for . Regulation TNF PMS1 23593410 2773522 The nuclear transcription factor-kappa B ( NF-?B ) signaling pathway plays a critical role in tumor cell survival , proliferation , invasion , metastasis , and angiogenesis , so we determined the *effects* of and its structural analogs on [tumor necrosis factor-a (TNF-a)] induced activation of NF-?B signaling . Regulation TNF PMS1 9793792 542854 By contrast , the peritoneal cavity had greatly increased local LPS and TNF-alpha levels and a diminished [TNF-alpha] *response* to LPS . Regulation TNF PMS2 23593410 2773523 The nuclear transcription factor-kappa B ( NF-?B ) signaling pathway plays a critical role in tumor cell survival , proliferation , invasion , metastasis , and angiogenesis , so we determined the *effects* of and its structural analogs on [tumor necrosis factor-a (TNF-a)] induced activation of NF-?B signaling . Regulation TNF PMS2 9793792 542855 By contrast , the peritoneal cavity had greatly increased local LPS and [TNF-alpha] levels and a diminished TNF-alpha *response* to LPS . Regulation TNF POLDIP2 11920316 926079 The *role* of and extracellular signal regulated kinase ( ERK ) mitogen activated protein (MAP) kinase pathways in the up-regulation of inducible nitric oxide synthase (iNOS) and [tumor necrosis factor (TNF)] production in macrophages stimulated with Streptococcus pneumoniae was examined . Regulation TNF POLDIP2 15312829 1285295 *regulates* the expression of the cytokines tumor necrosis ( [TNF)-alpha] and interleukin (IL)-1beta , 2 mediators involved in the development of OB in a tracheal transplant model . Regulation TNF POLDIP2 15321739 1286613 The adenosine receptor agonist 2-p- ( carboxyethyl ) phenethylamino-5'-N-ethylcarboxamidoadenosine hydrochloride ( CGS 21680 ) decreased stability and half-life of PMA/phytohemagglutinin induced TNF-alpha mRNA from 80 to 37 min . p38 signaling pathways control TNF-alpha mRNA stability in macrophages and we confirmed in our cells that was *involved* in controlling [TNF-alpha] release post-transcriptionally . Regulation TNF POLDIP2 16231199 1470322 The activated protein kinase ( p38-MAPK ) *plays* a key role in lipopolysaccharide induced [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1 (IL-1) release during the inflammatory process , emerging as an attractive target for new anti-inflammatory agents . Regulation TNF POLDIP2 17591882 1764544 Differences between inhibitor *effects* on [TNFalpha] and IL-1alpha induction of MMP-3 suggest divergent p38 isoform use , as do the morphologic responses . Regulation TNF POLDIP2 17668318 1805306 Pharmacological inhibitor of tyrosine kinase , PI3 kinase , protein kinase C , p42/44 , , JNK and intracellular calcium immobilizing agent down *regulated* the WGA induced expression of cytokines [TNF-alpha] , IL-1beta , IL-12 and IFN-gamma . Regulation TNF POLDIP2 20716917 2181796 [Tumor necrosis factor-alpha] and apoptosis signal regulating kinase 1 *control* reactive oxygen species release , mitochondrial autophagy , and c-Jun N-terminal phosphorylation during necrotizing enterocolitis . Regulation TNF PON1 21986851 2567854 The *effects* of on inducibility of [tumor necrosis factor (TNF)-a] , nitric oxide ( NO ) , and nicotinamide adenine dinucleotide phosphate ( NADP ( + ) ) production , as well as bactericidal activity , were investigated in RAW264.7 cells or primary alveolar macrophages . Regulation TNF PPARA 10377130 623614 Therefore , we examined the *role* of activators on the regulation of [TNF] expression in a mouse model of endotoxemia . Regulation TNF PPARA 11009565 735944 Therefore , we examined the *effects* of and PPARgamma activators on expression of [TNF-alpha] in neonatal rat cardiac myocytes . Regulation TNF PPARA 17320860 1711780 We studied the *effect* of the activation of macrophages on the modulation of the [tumor necrosis factor alpha (TNFalpha)] expression in adipocytes using a cell culture system . Regulation TNF PPARA 21888945 2521903 Collectively , our present data establishes that activities are functionally *involved* in modulating the interaction between the BMP system and [TNF-a] receptor signaling that is crucial for bone metabolism . Regulation TNF PPARD 16698033 1570059 In this study , we investigated the *effects* of and its synthetic ligand GW0742 on [TNFalpha] production in cultured cardiomyocytes . Regulation TNF PPARG 10917568 716784 The *effect* of activation of peroxisome proliferator activated receptor gamma ( PPARgamma ) on human monocyte function : ligands do not inhibit [tumor necrosis factor-alpha] release in human monocytic cell line THP-1 . Regulation TNF PPARG 11009565 735945 Therefore , we examined the *effects* of PPARalpha and activators on expression of [TNF-alpha] in neonatal rat cardiac myocytes . Regulation TNF PPARG 12364456 995190 The aim of this study was to elucidate whether natural [ 15-deoxy-Delta ( 12,14 ) -PGJ ( 2 ) ( 15d-PGJ ( 2 ) ) ] and synthetic ( troglitazone ) ligands *regulate* the secretion of IL-6 , IL-8 , and [TNF-alpha] from human intrauterine tissues . Regulation TNF PPARG 15669179 1350504 To investigate the *effect* of peroxisome proliferator activated receptor-alpha ( PPAR alpha ) and activators on [tumor necrosis factor-alpha (TNFalpha)] expression in neonatal rat cardiac myocytes . Regulation TNF PPARG 16705060 1570088 The adipose tissue triglyceride lipase ATGL/PNPLA2 is downregulated by insulin and [TNF-alpha] in 3T3-L1 adipocytes and is a *target* for transactivation by . Regulation TNF PPARG 17325208 1706468 In these cells , we observed *dependent* inhibition of nuclear factor-kappaB (NF-kappaB) activation and [TNF-alpha] expression in response to PMA . Regulation TNF PPP1R3A 17276889 1691892 In this report , the *effects* of ginsenoside-Rd and -Rb2 , two protopanaxadiols , and and -Re , two protopanaxatriols , on the production of nitric oxide ( NO ) and [TNF-alpha] ( TNF-alpha ) by lipopolysaccharide (LPS) activated N9 microglial cells were studied . Regulation TNF PPP1R3B 20153259 2248513 Using PBMC from healthy individuals , we show that monocytes differentiated with IL-15 ( IL15-DC ) produced IL-1beta , IL-6 , IL-15 , IL-23 , [TNFalpha] and CCL20 in *response* to and activated contact dependent Th17 and Th1 responses from autologous CD4 ( + ) T cells . Regulation TNF PPP2CA 15618191 1357645 Our studies are the first to demonstrate an important role for the transcription factor CREB in [TNF-alpha] production by mycobacterium infected macrophages , as well as a *role* for M. avium 's induction of phosphatase activity as a mechanism to limit macrophage activation . Regulation TNF PPP2R1A 15618191 1357646 Our studies are the first to demonstrate an important role for the transcription factor CREB in [TNF-alpha] production by mycobacterium infected macrophages , as well as a *role* for M. avium 's induction of phosphatase activity as a mechanism to limit macrophage activation . Regulation TNF PPP2R2B 15618191 1357647 Our studies are the first to demonstrate an important role for the transcription factor CREB in [TNF-alpha] production by mycobacterium infected macrophages , as well as a *role* for M. avium 's induction of phosphatase activity as a mechanism to limit macrophage activation . Regulation TNF PPP3CA 16380462 1539846 Collectively , these data verify the *role* of and NFAT in CaR mediated [TNF] production by mTAL cells . Regulation TNF PPP3CA 17197194 1663832 Here we investigated whether skeletal myocytes produce IL-6 in a *dependent* manner , and whether [TNF-alpha] , an inducer of IL-6 , is affected by these stimuli . Regulation TNF PPP3CB 16380462 1539847 Collectively , these data verify the *role* of and NFAT in CaR mediated [TNF] production by mTAL cells . Regulation TNF PPP3CB 17197194 1663833 Here we investigated whether skeletal myocytes produce IL-6 in a *dependent* manner , and whether [TNF-alpha] , an inducer of IL-6 , is affected by these stimuli . Regulation TNF PPP3CC 16380462 1539848 Collectively , these data verify the *role* of and NFAT in CaR mediated [TNF] production by mTAL cells . Regulation TNF PPP3CC 17197194 1663834 Here we investigated whether skeletal myocytes produce IL-6 in a *dependent* manner , and whether [TNF-alpha] , an inducer of IL-6 , is affected by these stimuli . Regulation TNF PPP5C 17023568 1674275 had the same *effects* as 17beta-estradiol on IL-6 and [TNF-alpha] production by Kupffer cells and SMPhi , and DPN had the same effects on AMPhi and PBMC . Regulation TNF PPP5C 19628068 2112807 Neither nor DPN *affected* myocardial production of [TNF-alpha] or IL-1beta . Regulation TNF PRDX2 19083427 2003447 The *effects* of short-chain fatty acids ( butyrate , propionate , and acetate ) and , a typical histone deacetylase inhibitor , on [tumor necrosis factor (TNF)-alpha] secretion and nuclear factor kappaB (NF-kappaB) activation in peripheral blood mononuclear cells induced with lipopolysaccharide were evaluated in relation to prostaglandin E ( 2 ) ( PGE ( 2 ) ) secretion . Regulation TNF PRDX2 23026070 2716393 however , *affected* GH but not [TNF-a] mRNA expression . Regulation TNF PRKAA1 15120611 1242019 These results suggest that the effect of AICAR on [TNF-alpha] suppression in RAW 264.7 cells is *independent* of activation . Regulation TNF PRKAA1 19296827 2114424 The aim of the present study was to examine in vitro the effects of EPA on visfatin production and the potential *involvement* of both in the absence or presence of [TNF-alpha] . Regulation TNF PRKAA1 19853624 2196694 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( IL-1 beta , [TNF-alpha] ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Regulation TNF PRKAA1 19853624 2196754 Furthermore , we found that the effects of AICAR on IL-6 and [TNF-alpha] ( 12 , 24h ) release and on the expression of iNOS and NF-kappaB p65 are not *dependent* because the pre-treatment of LPS activated microglia with compound C ( a pharmacological inhibitor of AMPK ) did not reverse the effect of AICAR . Regulation TNF PRKAA1 21352507 2426445 In conclusion , IL-6 affects exercise induced glycogen use , signalling and [TNF-a] mRNA *responses* in mouse skeletal muscle . Regulation TNF PRKAA2 15120611 1242020 These results suggest that the effect of AICAR on [TNF-alpha] suppression in RAW 264.7 cells is *independent* of activation . Regulation TNF PRKAA2 19296827 2114425 The aim of the present study was to examine in vitro the effects of EPA on visfatin production and the potential *involvement* of both in the absence or presence of [TNF-alpha] . Regulation TNF PRKAA2 19853624 2196695 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( IL-1 beta , [TNF-alpha] ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Regulation TNF PRKAA2 19853624 2196755 Furthermore , we found that the effects of AICAR on IL-6 and [TNF-alpha] ( 12 , 24h ) release and on the expression of iNOS and NF-kappaB p65 are not *dependent* because the pre-treatment of LPS activated microglia with compound C ( a pharmacological inhibitor of AMPK ) did not reverse the effect of AICAR . Regulation TNF PRKAA2 21352507 2426446 In conclusion , IL-6 affects exercise induced glycogen use , signalling and [TNF-a] mRNA *responses* in mouse skeletal muscle . Regulation TNF PRKAB1 15120611 1242021 These results suggest that the effect of AICAR on [TNF-alpha] suppression in RAW 264.7 cells is *independent* of activation . Regulation TNF PRKAB1 19296827 2114426 The aim of the present study was to examine in vitro the effects of EPA on visfatin production and the potential *involvement* of both in the absence or presence of [TNF-alpha] . Regulation TNF PRKAB1 19853624 2196696 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( IL-1 beta , [TNF-alpha] ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Regulation TNF PRKAB1 19853624 2196756 Furthermore , we found that the effects of AICAR on IL-6 and [TNF-alpha] ( 12 , 24h ) release and on the expression of iNOS and NF-kappaB p65 are not *dependent* because the pre-treatment of LPS activated microglia with compound C ( a pharmacological inhibitor of AMPK ) did not reverse the effect of AICAR . Regulation TNF PRKAB1 21352507 2426447 In conclusion , IL-6 affects exercise induced glycogen use , signalling and [TNF-a] mRNA *responses* in mouse skeletal muscle . Regulation TNF PRKAB2 15120611 1242022 These results suggest that the effect of AICAR on [TNF-alpha] suppression in RAW 264.7 cells is *independent* of activation . Regulation TNF PRKAB2 19296827 2114427 The aim of the present study was to examine in vitro the effects of EPA on visfatin production and the potential *involvement* of both in the absence or presence of [TNF-alpha] . Regulation TNF PRKAB2 19853624 2196697 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( IL-1 beta , [TNF-alpha] ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Regulation TNF PRKAB2 19853624 2196757 Furthermore , we found that the effects of AICAR on IL-6 and [TNF-alpha] ( 12 , 24h ) release and on the expression of iNOS and NF-kappaB p65 are not *dependent* because the pre-treatment of LPS activated microglia with compound C ( a pharmacological inhibitor of AMPK ) did not reverse the effect of AICAR . Regulation TNF PRKAB2 21352507 2426448 In conclusion , IL-6 affects exercise induced glycogen use , signalling and [TNF-a] mRNA *responses* in mouse skeletal muscle . Regulation TNF PRKACB 11675405 873357 It is likely that and MAPK ( p42/p44 , p38 ) may *play* a critical role in the regulation of the Stx-2 induced [TNF-alpha] transcription via beta(2)-adrenoceptor activation . Regulation TNF PRKACB 12967650 1138952 Except for IL-10 , the pharmacological *effect* of cAMP elevating agents or inhibitors on radiation induced [TNF-alpha] and IL-6 mRNA expression was associated with a concomitant regulation of cytokine release . Regulation TNF PRKACB 18475747 407583 We investigated the *effects* of specific inhibitors of cAMP dependent and cGMP dependent protein kinase ( PKG ) on the inhibitory activity of phosphodiesterase ( PDE ) type 4 inhibitors and of the cell permeable analogue of cAMP , db-cAMP on LPS induced [TNF-alpha] release from human mononuclear cells . Regulation TNF PRKACB 22532103 2744723 In vitro , PACAP treatment not only diminished macrophage [tumor necrosis factor] alpha/IL-6/IL-12 levels in a *dependent* manner , but also prevented necrosis and apoptosis in primary mouse hepatocyte cultures . Regulation TNF PRKACB 23744729 2838514 In vitro , VIP not only diminished macrophage [tumor necrosis factor] a/IL-6/IL-12 expression in a *dependent* manner but also prevented necrosis/apoptosis in primary mouse hepatocyte cultures . Regulation TNF PRKACB 2549168 117425 As in these typical TNF producer cells , the production of [TNF] is also *controlled* by and PKC , a regulatory circuit is proposed , by which these two independent signal pathways antagonistically regulate TNF production and , at the receptor level , TNF sensitivity . Regulation TNF PRKACG 11675405 873358 It is likely that and MAPK ( p42/p44 , p38 ) may *play* a critical role in the regulation of the Stx-2 induced [TNF-alpha] transcription via beta(2)-adrenoceptor activation . Regulation TNF PRKACG 12967650 1138953 Except for IL-10 , the pharmacological *effect* of cAMP elevating agents or inhibitors on radiation induced [TNF-alpha] and IL-6 mRNA expression was associated with a concomitant regulation of cytokine release . Regulation TNF PRKACG 18475747 407584 We investigated the *effects* of specific inhibitors of cAMP dependent and cGMP dependent protein kinase ( PKG ) on the inhibitory activity of phosphodiesterase ( PDE ) type 4 inhibitors and of the cell permeable analogue of cAMP , db-cAMP on LPS induced [TNF-alpha] release from human mononuclear cells . Regulation TNF PRKACG 22532103 2744724 In vitro , PACAP treatment not only diminished macrophage [tumor necrosis factor] alpha/IL-6/IL-12 levels in a *dependent* manner , but also prevented necrosis and apoptosis in primary mouse hepatocyte cultures . Regulation TNF PRKACG 23744729 2838515 In vitro , VIP not only diminished macrophage [tumor necrosis factor] a/IL-6/IL-12 expression in a *dependent* manner but also prevented necrosis/apoptosis in primary mouse hepatocyte cultures . Regulation TNF PRKACG 2549168 117426 As in these typical TNF producer cells , the production of [TNF] is also *controlled* by and PKC , a regulatory circuit is proposed , by which these two independent signal pathways antagonistically regulate TNF production and , at the receptor level , TNF sensitivity . Regulation TNF PRKAG1 15120611 1242023 These results suggest that the effect of AICAR on [TNF-alpha] suppression in RAW 264.7 cells is *independent* of activation . Regulation TNF PRKAG1 19296827 2114428 The aim of the present study was to examine in vitro the effects of EPA on visfatin production and the potential *involvement* of both in the absence or presence of [TNF-alpha] . Regulation TNF PRKAG1 19853624 2196698 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( IL-1 beta , [TNF-alpha] ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Regulation TNF PRKAG1 19853624 2196758 Furthermore , we found that the effects of AICAR on IL-6 and [TNF-alpha] ( 12 , 24h ) release and on the expression of iNOS and NF-kappaB p65 are not *dependent* because the pre-treatment of LPS activated microglia with compound C ( a pharmacological inhibitor of AMPK ) did not reverse the effect of AICAR . Regulation TNF PRKAG1 21352507 2426449 In conclusion , IL-6 affects exercise induced glycogen use , signalling and [TNF-a] mRNA *responses* in mouse skeletal muscle . Regulation TNF PRKAG2 15120611 1242024 These results suggest that the effect of AICAR on [TNF-alpha] suppression in RAW 264.7 cells is *independent* of activation . Regulation TNF PRKAG2 19296827 2114429 The aim of the present study was to examine in vitro the effects of EPA on visfatin production and the potential *involvement* of both in the absence or presence of [TNF-alpha] . Regulation TNF PRKAG2 19853624 2196699 The presented evidence supports the conclusion that activated by AICAR is *involved* in regulation of ROS and cytokine production ( IL-1 beta , [TNF-alpha] ( 6h ) , IL-10 and TGF-beta ) as well as arginase I and PGC-1alpha expression . Regulation TNF PRKAG2 19853624 2196759 Furthermore , we found that the effects of AICAR on IL-6 and [TNF-alpha] ( 12 , 24h ) release and on the expression of iNOS and NF-kappaB p65 are not *dependent* because the pre-treatment of LPS activated microglia with compound C ( a pharmacological inhibitor of AMPK ) did not reverse the effect of AICAR . Regulation TNF PRKAG2 21352507 2426450 In conclusion , IL-6 affects exercise induced glycogen use , signalling and [TNF-a] mRNA *responses* in mouse skeletal muscle . Regulation TNF PRKAR1A 11675405 873359 It is likely that and MAPK ( p42/p44 , p38 ) may *play* a critical role in the regulation of the Stx-2 induced [TNF-alpha] transcription via beta(2)-adrenoceptor activation . Regulation TNF PRKAR1A 12967650 1138954 Except for IL-10 , the pharmacological *effect* of cAMP elevating agents or inhibitors on radiation induced [TNF-alpha] and IL-6 mRNA expression was associated with a concomitant regulation of cytokine release . Regulation TNF PRKAR1A 18475747 407585 We investigated the *effects* of specific inhibitors of cAMP dependent and cGMP dependent protein kinase ( PKG ) on the inhibitory activity of phosphodiesterase ( PDE ) type 4 inhibitors and of the cell permeable analogue of cAMP , db-cAMP on LPS induced [TNF-alpha] release from human mononuclear cells . Regulation TNF PRKAR1A 22532103 2744725 In vitro , PACAP treatment not only diminished macrophage [tumor necrosis factor] alpha/IL-6/IL-12 levels in a *dependent* manner , but also prevented necrosis and apoptosis in primary mouse hepatocyte cultures . Regulation TNF PRKAR1A 23744729 2838516 In vitro , VIP not only diminished macrophage [tumor necrosis factor] a/IL-6/IL-12 expression in a *dependent* manner but also prevented necrosis/apoptosis in primary mouse hepatocyte cultures . Regulation TNF PRKAR1A 2549168 117427 As in these typical TNF producer cells , the production of [TNF] is also *controlled* by and PKC , a regulatory circuit is proposed , by which these two independent signal pathways antagonistically regulate TNF production and , at the receptor level , TNF sensitivity . Regulation TNF PRKAR1B 11675405 873360 It is likely that and MAPK ( p42/p44 , p38 ) may *play* a critical role in the regulation of the Stx-2 induced [TNF-alpha] transcription via beta(2)-adrenoceptor activation . Regulation TNF PRKAR1B 12967650 1138955 Except for IL-10 , the pharmacological *effect* of cAMP elevating agents or inhibitors on radiation induced [TNF-alpha] and IL-6 mRNA expression was associated with a concomitant regulation of cytokine release . Regulation TNF PRKAR1B 18475747 407586 We investigated the *effects* of specific inhibitors of cAMP dependent and cGMP dependent protein kinase ( PKG ) on the inhibitory activity of phosphodiesterase ( PDE ) type 4 inhibitors and of the cell permeable analogue of cAMP , db-cAMP on LPS induced [TNF-alpha] release from human mononuclear cells . Regulation TNF PRKAR1B 22532103 2744726 In vitro , PACAP treatment not only diminished macrophage [tumor necrosis factor] alpha/IL-6/IL-12 levels in a *dependent* manner , but also prevented necrosis and apoptosis in primary mouse hepatocyte cultures . Regulation TNF PRKAR1B 23744729 2838517 In vitro , VIP not only diminished macrophage [tumor necrosis factor] a/IL-6/IL-12 expression in a *dependent* manner but also prevented necrosis/apoptosis in primary mouse hepatocyte cultures . Regulation TNF PRKAR1B 2549168 117428 As in these typical TNF producer cells , the production of [TNF] is also *controlled* by and PKC , a regulatory circuit is proposed , by which these two independent signal pathways antagonistically regulate TNF production and , at the receptor level , TNF sensitivity . Regulation TNF PRKAR2A 11675405 873361 It is likely that and MAPK ( p42/p44 , p38 ) may *play* a critical role in the regulation of the Stx-2 induced [TNF-alpha] transcription via beta(2)-adrenoceptor activation . Regulation TNF PRKAR2A 12967650 1138956 Except for IL-10 , the pharmacological *effect* of cAMP elevating agents or inhibitors on radiation induced [TNF-alpha] and IL-6 mRNA expression was associated with a concomitant regulation of cytokine release . Regulation TNF PRKAR2A 18475747 407587 We investigated the *effects* of specific inhibitors of cAMP dependent and cGMP dependent protein kinase ( PKG ) on the inhibitory activity of phosphodiesterase ( PDE ) type 4 inhibitors and of the cell permeable analogue of cAMP , db-cAMP on LPS induced [TNF-alpha] release from human mononuclear cells . Regulation TNF PRKAR2A 22532103 2744727 In vitro , PACAP treatment not only diminished macrophage [tumor necrosis factor] alpha/IL-6/IL-12 levels in a *dependent* manner , but also prevented necrosis and apoptosis in primary mouse hepatocyte cultures . Regulation TNF PRKAR2A 23744729 2838518 In vitro , VIP not only diminished macrophage [tumor necrosis factor] a/IL-6/IL-12 expression in a *dependent* manner but also prevented necrosis/apoptosis in primary mouse hepatocyte cultures . Regulation TNF PRKAR2A 2549168 117429 As in these typical TNF producer cells , the production of [TNF] is also *controlled* by and PKC , a regulatory circuit is proposed , by which these two independent signal pathways antagonistically regulate TNF production and , at the receptor level , TNF sensitivity . Regulation TNF PRKAR2B 11675405 873362 It is likely that and MAPK ( p42/p44 , p38 ) may *play* a critical role in the regulation of the Stx-2 induced [TNF-alpha] transcription via beta(2)-adrenoceptor activation . Regulation TNF PRKAR2B 12967650 1138957 Except for IL-10 , the pharmacological *effect* of cAMP elevating agents or inhibitors on radiation induced [TNF-alpha] and IL-6 mRNA expression was associated with a concomitant regulation of cytokine release . Regulation TNF PRKAR2B 18475747 407588 We investigated the *effects* of specific inhibitors of cAMP dependent and cGMP dependent protein kinase ( PKG ) on the inhibitory activity of phosphodiesterase ( PDE ) type 4 inhibitors and of the cell permeable analogue of cAMP , db-cAMP on LPS induced [TNF-alpha] release from human mononuclear cells . Regulation TNF PRKAR2B 22532103 2744728 In vitro , PACAP treatment not only diminished macrophage [tumor necrosis factor] alpha/IL-6/IL-12 levels in a *dependent* manner , but also prevented necrosis and apoptosis in primary mouse hepatocyte cultures . Regulation TNF PRKAR2B 23744729 2838519 In vitro , VIP not only diminished macrophage [tumor necrosis factor] a/IL-6/IL-12 expression in a *dependent* manner but also prevented necrosis/apoptosis in primary mouse hepatocyte cultures . Regulation TNF PRKAR2B 2549168 117430 As in these typical TNF producer cells , the production of [TNF] is also *controlled* by and PKC , a regulatory circuit is proposed , by which these two independent signal pathways antagonistically regulate TNF production and , at the receptor level , TNF sensitivity . Regulation TNF PRKCA 12385023 1025341 Inhibition of LPS induced PKC activity using pseudosubstrate peptides specific for PKC isoforms established that PKC epsilon but not was *involved* in the production of IL-12 and [TNF-alpha] . Regulation TNF PRKCA 15499968 1326833 The aim of current study was to investigate the *effect* of activation by FB1 on NF-kappaB activation and subsequently on [TNFalpha] gene expression and caspase 3 induction in LLC-PK1 cells . Regulation TNF PRKCB 11478844 842085 *Involvement* of in PTH , [TNF-alpha] , and IL-1 beta effects on IL-6 promoter in osteoblastic cells and on PTH stimulated bone resorption . Regulation TNF PRKCB 12385023 1025342 Inhibition of LPS induced PKC activity using pseudosubstrate peptides specific for PKC isoforms established that PKC epsilon but not was *involved* in the production of IL-12 and [TNF-alpha] . Regulation TNF PRKDC 9636658 513402 The *role* of , a protein kinase involved in the response to DNA damage , in the activation of NF kappa B by IR and [TNF alpha] was examined . Regulation TNF PRL 7758825 307621 To determine if PRL stimulates astrocyte proliferation and cytokine expression in vivo , we examined the *effect* of on the wound induced increase in the expression of glial fibrillary acid protein (GFAP) and [tumor necrosis factor-alpha (TNF-alpha)] in the CNS . Regulation TNF PRL 8532376 336995 These data suggest that can *regulate* in vivo endogenous [TNF-alpha] production in the cytokine cascade . Regulation TNF PRLR 24997655 2952762 This study aims to investigate the *role* of activation in regulating the expression and release of [TNF-a] from CD14 ( + ) monocytes . Regulation TNF PRMT5 19372584 2058992 had no *effect* on [TNF-alpha] mediated NF-kappaB signaling . Regulation TNF PTBP1 20237317 2265978 We demonstrate that but not macrophages have high levels of IRF5 protein , and that IRF5 is *responsible* for the late-phase expression of [TNF] , which is absent in macrophages . Regulation TNF PTBP2 20237317 2265974 We demonstrate that but not macrophages have high levels of IRF5 protein , and that IRF5 is *responsible* for the late-phase expression of [TNF] , which is absent in macrophages . Regulation TNF PTEN 17373630 1713847 *Role* of tumor suppressor in [tumor necrosis factor] alpha induced inhibition of insulin signaling in murine skeletal muscle C2C12 cells . Regulation TNF PTGS2 12576525 1058078 Abrogating the induced COX-2 activity reversed the TNFalpha induced inhibition of differentiation by approximately 70 % , implying a *role* for in mediating [TNFalpha] signaling . Regulation TNF PTGS2 17761349 1790150 After different kinds of cyclooxygenase (COX) inhibitors were administrated , it showed that the effects of DHAP on [TNF-alpha] and apoptosis were *dependent* . Regulation TNF PTGS2 20675368 2322621 Studies with the COX-2-specific inhibitor , melaxicam , and with COX-2 overexpressing cells demonstrated the positive regulation of [TNF-a] and negative *regulation* of cAMP degradation-specific phosphodiesterase (PDE) 4D by . Regulation TNF PTGS2 21995864 2557017 *Effect* of nonselective and selective inhibitors on memory dysfunction , glutathione system , and [tumor necrosis factor] alpha level against cerebral ischemia reperfusion injury . Regulation TNF PTK2 10653605 663284 In the current study , we determined the *effects* of inhibitors , genistein and herbimycin A , on the induction of MnSOD and [TNFalpha] in human monocytes . Regulation TNF PTK2 17719638 1842570 Pharmacological disruption of lipid rafts microdomains abolished the assembly of HLA-DR/CD18/PTK signaling complex , HLA-DR mediated tyrosine activation , and the *dependent* [TNFalpha] expression in IFNgamma primed THP-1 cells . Regulation TNF PTK2 7519214 265506 *Involvement* of protein kinase C and in lipopolysaccharide induced [TNF-alpha] and IL-1 beta production by human monocytes . Regulation TNF PTK2 8188366 256774 Finally , our results , obtained with protein tyrosine kinase inhibitors and antiphosphotyrosine Western blotting ( immunoblotting ) , indicate that is *involved* in MAM induced IL-1 beta and [TNF-alpha] gene expression in the THP-1 monocytic cell line . Regulation TNF PTK2 8537661 346156 The results obtained with other modulatory substances , including different protein kinase and G protein inhibitors , suggest that calmodulin dependent protein kinase , , and a cholera-toxin-sensitive G protein are *involved* in both PG- and LPS induced [TNF-alpha] release . Regulation TNF PTK2 9178968 434349 Therefore , both and PKC may be *involved* in LPS stimulated [TNF-alpha] secretion . Regulation TNF PTK6 10653605 663285 In the current study , we determined the *effects* of inhibitors , genistein and herbimycin A , on the induction of MnSOD and [TNFalpha] in human monocytes . Regulation TNF PTK6 17719638 1842571 Pharmacological disruption of lipid rafts microdomains abolished the assembly of HLA-DR/CD18/PTK signaling complex , HLA-DR mediated tyrosine activation , and the *dependent* [TNFalpha] expression in IFNgamma primed THP-1 cells . Regulation TNF PTK6 7519214 265507 *Involvement* of protein kinase C and in lipopolysaccharide induced [TNF-alpha] and IL-1 beta production by human monocytes . Regulation TNF PTK6 8188366 256775 Finally , our results , obtained with protein tyrosine kinase inhibitors and antiphosphotyrosine Western blotting ( immunoblotting ) , indicate that is *involved* in MAM induced IL-1 beta and [TNF-alpha] gene expression in the THP-1 monocytic cell line . Regulation TNF PTK6 8537661 346157 The results obtained with other modulatory substances , including different protein kinase and G protein inhibitors , suggest that calmodulin dependent protein kinase , , and a cholera-toxin-sensitive G protein are *involved* in both PG- and LPS induced [TNF-alpha] release . Regulation TNF PTK6 9178968 434350 Therefore , both and PKC may be *involved* in LPS stimulated [TNF-alpha] secretion . Regulation TNF PTK7 10653605 663286 In the current study , we determined the *effects* of inhibitors , genistein and herbimycin A , on the induction of MnSOD and [TNFalpha] in human monocytes . Regulation TNF PTK7 17719638 1842572 Pharmacological disruption of lipid rafts microdomains abolished the assembly of HLA-DR/CD18/PTK signaling complex , HLA-DR mediated tyrosine activation , and the *dependent* [TNFalpha] expression in IFNgamma primed THP-1 cells . Regulation TNF PTK7 7519214 265508 *Involvement* of protein kinase C and in lipopolysaccharide induced [TNF-alpha] and IL-1 beta production by human monocytes . Regulation TNF PTK7 8188366 256776 Finally , our results , obtained with protein tyrosine kinase inhibitors and antiphosphotyrosine Western blotting ( immunoblotting ) , indicate that is *involved* in MAM induced IL-1 beta and [TNF-alpha] gene expression in the THP-1 monocytic cell line . Regulation TNF PTK7 8537661 346158 The results obtained with other modulatory substances , including different protein kinase and G protein inhibitors , suggest that calmodulin dependent protein kinase , , and a cholera-toxin-sensitive G protein are *involved* in both PG- and LPS induced [TNF-alpha] release . Regulation TNF PTK7 9178968 434351 Therefore , both and PKC may be *involved* in LPS stimulated [TNF-alpha] secretion . Regulation TNF PTMA 12579833 1029630 [ *Effect* of recombinant on secretion of IFN-gamma , IFN-alpha and [TNF-alpha] in vitro ] . Regulation TNF PTPN6 10640770 660668 Positive *regulation* of c-Jun N-terminal kinase and [TNF-alpha] production but not histamine release by in RBL-2H3 mast cells . Regulation TNF PTX3 10464849 640523 The aim of this study was to investigate the *effects* of on the production of [TNF-alpha] , IL-1 beta , IL-6 and GM-CSF by lipopolysaccharide (LPS) stimulated alveolar macrophages ( AM ) . Regulation TNF PTX3 11835758 911448 Peritoneal macrophages were harvested at 6 hours and 1 , 2 , 3 , 7 days after traumatic hemorrhagic shock to determine the *effects* of pertussis toxin ( , as a specific inhibitor to Gi ( alpha ) and cholera toxin ( CTX , as a stimulant to Gs ( alpha ) on macrophage-Ia expression and [TNF-alpha] production and levels of Gi ( alpha ) and Gs ( alpha ) . Regulation TNF PTX3 1340532 209291 The aim of this work is to reinvestigate the *action* on [TNF alpha] and IL-6 production using a whole blood ex-vivo model . Regulation TNF PTX3 1385797 190861 In this study , we found that differentially *regulates* the production of [TNF-alpha] and interleukin-6 (IL-6) . Regulation TNF PTX3 1385797 190875 We suggest that cAMP could be involved in these differential *effects* of on production of [TNF-alpha] and of IL-6 . Regulation TNF PTX3 8699858 343308 Because inflammatory processes involve both leukocytes and vascular cells , we tested the *effects* of on [TNF] and interleukin-6 (IL-6) production by the vessel wall in response to lipopolysaccharide (LPS) . Regulation TNF PTX3 9172017 407008 We investigated *effects* on production and mRNA expression of [TNF alpha] , IL-1 beta , IL-6 , IL-8 , TNF beta and IL-10 . Regulation TNF PTX3 9227316 443179 The present study concerns the *effect* of the xanthine derivates lisofylline ( LSF ) and on the production of pro-inflammatory cytokines [tumour-necrosis factor-alpha (TNF-alpha)] and interleukin-1 beta (IL-1 beta) and the de-activating cytokine interleukin-10 (IL-10) by human leucocytes during stimulation with lipopolysaccharide (LPS) , heat killed Gram negative bacteria (GNB) or Gram positive bacteria ( GPB ) . Regulation TNF PTX3 9486396 488340 The *effect* of on [TNF-alpha] production was examined in leprosy patients at the protein level and at the transcriptional level as well . Regulation TNF PTX3 9667590 518611 In vitro studies with myelin basic protein (MBP)-specific T-cell lines revealed a synergistic suppressive *effect* of IFN-beta1b and the phosphodiesterase inhibitor on proliferation and the production of [tumor necrosis factor-alpha (TNF-alpha)] , lymphotoxin ( LT ) , and interferon-gamma (IFN-gamma) . Regulation TNF PTX4 10464849 640522 The aim of this study was to investigate the *effects* of on the production of [TNF-alpha] , IL-1 beta , IL-6 and GM-CSF by lipopolysaccharide (LPS) stimulated alveolar macrophages ( AM ) . Regulation TNF PTX4 11835758 911447 Peritoneal macrophages were harvested at 6 hours and 1 , 2 , 3 , 7 days after traumatic hemorrhagic shock to determine the *effects* of pertussis toxin ( , as a specific inhibitor to Gi ( alpha ) and cholera toxin ( CTX , as a stimulant to Gs ( alpha ) on macrophage-Ia expression and [TNF-alpha] production and levels of Gi ( alpha ) and Gs ( alpha ) . Regulation TNF PTX4 1340532 209290 The aim of this work is to reinvestigate the *action* on [TNF alpha] and IL-6 production using a whole blood ex-vivo model . Regulation TNF PTX4 1385797 190860 In this study , we found that differentially *regulates* the production of [TNF-alpha] and interleukin-6 (IL-6) . Regulation TNF PTX4 1385797 190874 We suggest that cAMP could be involved in these differential *effects* of on production of [TNF-alpha] and of IL-6 . Regulation TNF PTX4 8699858 343307 Because inflammatory processes involve both leukocytes and vascular cells , we tested the *effects* of on [TNF] and interleukin-6 (IL-6) production by the vessel wall in response to lipopolysaccharide (LPS) . Regulation TNF PTX4 9172017 407007 We investigated *effects* on production and mRNA expression of [TNF alpha] , IL-1 beta , IL-6 , IL-8 , TNF beta and IL-10 . Regulation TNF PTX4 9227316 443178 The present study concerns the *effect* of the xanthine derivates lisofylline ( LSF ) and on the production of pro-inflammatory cytokines [tumour-necrosis factor-alpha (TNF-alpha)] and interleukin-1 beta (IL-1 beta) and the de-activating cytokine interleukin-10 (IL-10) by human leucocytes during stimulation with lipopolysaccharide (LPS) , heat killed Gram negative bacteria (GNB) or Gram positive bacteria ( GPB ) . Regulation TNF PTX4 9486396 488339 The *effect* of on [TNF-alpha] production was examined in leprosy patients at the protein level and at the transcriptional level as well . Regulation TNF PTX4 9667590 518609 In vitro studies with myelin basic protein (MBP)-specific T-cell lines revealed a synergistic suppressive *effect* of IFN-beta1b and the phosphodiesterase inhibitor on proliferation and the production of [tumor necrosis factor-alpha (TNF-alpha)] , lymphotoxin ( LT ) , and interferon-gamma (IFN-gamma) . Regulation TNF PWP1 16755884 1571624 To investigate the *effect* of on serum levels of IL-6 and [TNF-alpha] in rats with chronic bacterial prostatitis (CBP) . Regulation TNF PWP2 16755884 1571625 To investigate the *effect* of on serum levels of IL-6 and [TNF-alpha] in rats with chronic bacterial prostatitis (CBP) . Regulation TNF QRICH1 18070149 1853797 Our objective was to determine the *effects* of on Toll-like receptor 4 (TLR-4) , myeloid differentiation factor 88 ( Myd88 ) and [tumour necrosis factor (TNF)-alpha] receptor associated factor 6 ( TRAF6 ) expression in intestinal mucosa following LPS endotoxaemia in a rat . Regulation TNF QRICH1 20094742 2272210 Peritoneal macrophages were pretreated with glutamine ( 0 , 0.6 , 2 and 10 mM ) before incubation with lipopolysaccharide (LPS) , and the *effects* of on the production of [tumor necrosis factor-alpha] and on the expression and activity of proteins involved in the NF-kappaB signaling pathway were studied by an enzyme linked immuno-sorbent assay , Western blotting , and an electrophoretic mobility shift assay . Regulation TNF QRICH1 21849119 2468673 [ Relationship between the *regulation* of intestinal NF-?B and [TNF-a] by and the protective effects of glutamine against intestinal injury ] . Regulation TNF QRICH1 22426906 2573166 *Effects* of enteral and parenteral on intestinal mucosa and on levels of blood glutamine , [tumor necrosis factor-alpha] , and interleukin-10 in an experimental sepsis model . Regulation TNF QRICH1 23454558 2771510 Quercetin also abrogated 's beneficial *effects* on renal [TNF-a] , chemokines , and neutrophil infiltration . Regulation TNF QRICH2 18070149 1853798 Our objective was to determine the *effects* of on Toll-like receptor 4 (TLR-4) , myeloid differentiation factor 88 ( Myd88 ) and [tumour necrosis factor (TNF)-alpha] receptor associated factor 6 ( TRAF6 ) expression in intestinal mucosa following LPS endotoxaemia in a rat . Regulation TNF QRICH2 20094742 2272211 Peritoneal macrophages were pretreated with glutamine ( 0 , 0.6 , 2 and 10 mM ) before incubation with lipopolysaccharide (LPS) , and the *effects* of on the production of [tumor necrosis factor-alpha] and on the expression and activity of proteins involved in the NF-kappaB signaling pathway were studied by an enzyme linked immuno-sorbent assay , Western blotting , and an electrophoretic mobility shift assay . Regulation TNF QRICH2 21849119 2468674 [ Relationship between the *regulation* of intestinal NF-?B and [TNF-a] by and the protective effects of glutamine against intestinal injury ] . Regulation TNF QRICH2 22426906 2573167 *Effects* of enteral and parenteral on intestinal mucosa and on levels of blood glutamine , [tumor necrosis factor-alpha] , and interleukin-10 in an experimental sepsis model . Regulation TNF QRICH2 23454558 2771511 Quercetin also abrogated 's beneficial *effects* on renal [TNF-a] , chemokines , and neutrophil infiltration . Regulation TNF RAB37 21805469 2495252 Taken together , these findings demonstrate that interacts with Munc13-1 to *control* [TNF-a] secretion from activated macrophages . Regulation TNF RAB7B 17395780 1766172 Here we demonstrate that can negatively *regulate* lipopolysaccharide (LPS) induced production of [tumor necrosis factor (TNF)-alpha] , IL-6 , nitric oxide , and IFN-beta , and potentiate LPS induced activation of mitogen activated protein kinase , nuclear factor kappaB , and IFN regulatory factor 3 signaling pathways in macrophages by promoting the degradation of TLR4 . Regulation TNF RAB7B 19587007 2111769 Accordingly , can negatively *regulate* TLR9 triggered production of [TNF-alpha] , IL-6 , and IFN-beta in macrophages by impairing activation of MAPKs and NF-kappaB pathways . Regulation TNF RAC1 19450605 2096930 Cardiac specific Rac1 knockout or administration of 17beta-estradiol down-regulated Rac1 expression , attenuated gp91(phox)-NADPH oxidase expression and activity , decreased phosphorylation of ERK1/2/p38 MAPK and inhibited cardiac TNF-alpha expression induced by LPS , suggesting an important *role* of and estrogen in LPS stimulated [TNF-alpha] expression in the heart . Regulation TNF RAC1 19684199 2150837 Asbestos increased [TNF-alpha] and ROS in a *dependent* manner . Regulation TNF RAC1 20518848 2430854 The aim of this study was to investigate the *role* of in [TNF-a] expression and cardiac dysfunction during endotoxemia and to determine the involvement of phosphoinositide-3 kinase (PI3K) in lipopolysaccharide (LPS) induced Rac1 activation . Regulation TNF RAC1 20518848 2430867 The *effect* of on [TNF-a] expression seems to be mediated by increased NADPH oxidase activity and ERK1/2 phosphorylation . Regulation TNF RAC1 23639811 2805077 Cumulatively , these results demonstrate that NOX2 and its activator subunits ( p47phox and ) control the secretion of TNF-a by the liver following I/R. Interestingly , in the absence of Kupffer cells and NOX2 , NOX1 *played* a dominant role in [TNF-a] production following hepatic I/R . Regulation TNF RAC2 23639811 2805078 Cumulatively , these results demonstrate that NOX2 and its activator subunits ( p47phox and ) control the secretion of TNF-a by the liver following I/R. Interestingly , in the absence of Kupffer cells and NOX2 , NOX1 *played* a dominant role in [TNF-a] production following hepatic I/R . Regulation TNF RAC3 23639811 2805079 Cumulatively , these results demonstrate that NOX2 and its activator subunits ( p47phox and ) control the secretion of TNF-a by the liver following I/R. Interestingly , in the absence of Kupffer cells and NOX2 , NOX1 *played* a dominant role in [TNF-a] production following hepatic I/R . Regulation TNF RAF1 7790814 313274 Using an enzyme linked immunosorbent assay for murine tumor necrosis factor alpha (TNF-alpha) , we found that LPS and PMA stimulation and delta Raf-1 : ER activation induced secretion of TNF-alpha , although the amount of [TNF-alpha] secreted in *response* to delta : ER activation and PMA stimulation was approximately 20-fold less than that secreted in response to LPS . Regulation TNF RAN 17698507 1805983 To determine whether *affects* LPS induced [TNF] release at a time near the onset of liver injury , male Sprague-Dawley rats were treated with 2.5 x 10 ( 6 ) endotoxin units ( EU ) /kg LPS or its saline vehicle ( iv ) and 2 h later with either 30 mg/kg RAN or sterile phosphate buffered saline vehicle ( iv ) . Regulation TNF RAPGEF1 20309718 2299858 The purpose of this study was to explore the *effect* of on lipopolysaccharide (LPS) stimulated [TNFalpha] and IL-6 expression in the human monocyte/macrophage cell line THP-1 , and to explore the mechanisms involved . Regulation TNF RB1 7763539 214488 increased glycolysis and IL-1 production by macrophages , but did not *affect* [TNF] production . Regulation TNF RBCK1 17449468 1749608 negatively *regulates* [tumor necrosis factor-] and interleukin-1 triggered NF-kappaB activation by targeting TAB2/3 for degradation . Regulation TNF RBCK1 17449468 1749622 Overexpression of negatively *regulates* TAB2/3 mediated and [TNF-] and IL-1 induced NF-kappaB activation , whereas knockdown of RBCK1 by RNA interference potentiates TNF- and IL-1 induced NF-kappaB activation . Regulation TNF RBL2 17276889 1691893 In this report , the *effects* of ginsenoside-Rd and <-Rb2> , two protopanaxadiols , and ginsenoside-Rg1 and -Re , two protopanaxatriols , on the production of nitric oxide ( NO ) and [TNF-alpha] ( TNF-alpha ) by lipopolysaccharide (LPS) activated N9 microglial cells were studied . Regulation TNF RBMS1 12818375 1103789 Using cultured rat alveolar NR 8383 macrophages , this study investigated the *effect* of [ 3- ( 5'-hydroxymethyl-2'-furyl ) -1-benzyl indazole ] , a soluble guanylyl cyclase ( sGC ) activator , on the production of [tumor necrosis factor-alpha (TNF alpha)] . Regulation TNF RELA 10402163 628902 The *plays* an essential role in transcriptional activation of [TNF] and IL-1 . Regulation TNF RELA 10449410 637276 The molecular basis for this resistance relies on an almost complete abrogation of *dependent* accumulation of [TNF-alpha] in the serum and a down-regulation of inducible nitric oxide synthase (iNOS) , leading to decreased NO synthesis , which is the main source of free radical generation during inflammation . Regulation TNF RELA 10486238 644710 *Role* of transcription factor in asbestos induced [TNFalpha] response from macrophages . Regulation TNF RELA 10498648 647631 The aim of this study is to investigate how PAF participates in the LPS induced and mediated *regulation* of [TNF-alpha] and CINC in regenerating rat livers . Regulation TNF RELA 10569191 567992 These results indicate that silica mediated free radical generation and activation *play* important roles in silica induced [TNFalpha] gene expression . Regulation TNF RELA 10616907 575890 We report that [TNF] induces DNA replication in growth arrested LE6 cells and that its effect *involves* the activation of and STAT3 and an increase in c-myc and IL-6 mRNAs . Regulation TNF RELA 10617597 657077 Incubation of macrophages with PAO1 led to *dependent* expression of inducible nitric-oxide synthase , COX-2 , and [tumor necrosis factor-alpha] , which was unaffected by inhibition of Rac1 or Cdc42 function . Regulation TNF RELA 10640779 660715 We tested whether *affects* [TNF-alpha] production by AMs using N-tosyl- < cmd SC > l < cmd /SC > -phenylalanine chloromethylketone ( TPCK ) or N-benzoyl- < cmd SC > l < cmd /SC > -tyrosine ethyl ester ( BTEE ) , which inhibit the degradation of I kappa B , or tricyclodecan-9-yl-xanthogenate-potassium ( D609 ) , which inhibits phospholipase C. Alveolar macrophages were exposed to LPS alone and with the chemical protease inhibitors TPCK , BTEE , and D609 . Regulation TNF RELA 10640779 660719 Our data show that [TNF-alpha] production by LPS stimulated AMs from asymptomatic HIV-seropositive and -seronegative individuals is *regulated* via the phospholipase C pathway and by DNA binding activity without obvious changes in I kappa B-alpha or I kappa B-beta protein concentrations . Regulation TNF RELA 10754326 682616 [TNF-alpha] gene expression in macrophages : *regulation* by is independent of c-Jun or C/EBP beta . Regulation TNF RELA 10938077 737416 [Tumor necrosis factor] alpha induced phosphorylation of on Ser529 is *controlled* by casein kinase II . Regulation TNF RELA 11093952 755140 [TNF-alpha] is *regulated* , and its upregulation in NF-kappaB1 knockouts may result from an alleviation of p50-p50 repression . Regulation TNF RELA 11279049 819488 These data show that [TNF-alpha] decreases AQP5 mRNA and protein expression and that the molecular pathway for this effect *involves* TNFR1 and activated . Regulation TNF RELA 11312646 805302 tightly *regulates* [TNF-alpha] transcription . Regulation TNF RELA 11367517 816872 Dexamethasone was used as a positive control due to its well characterised mechanism of action and *effects* on [TNF-alpha] expression . Regulation TNF RELA 11391531 822939 Because p53 is up-regulated by [TNF-alpha] in an *dependent* manner and the Mdr1b promoter contains a p53 binding site , we used liver cells expressing a dominant negative p53 to show that TNF-alpha up-regulation of Mdr1b is independent of functional p53 . Regulation TNF RELA 11675371 873170 Furthermore , transient transfection with a super-repressive mutant of IkappaBalpha ( IkappaBalpha-AA ) demonstrated that *plays* a critical role in CpG DNA mediated [TNF-alpha] expression . Regulation TNF RELA 11699072 878324 To determine the role of the human coronary artery endothelial cell ( HCA-EC ) in the cytokine response to endotoxin we measured in vitro [TNF-alpha] synthesis , TNF-alpha mRNA , and the associated *response* to LPS . Regulation TNF RELA 11922866 984261 Respiratory syncytial virus and [TNF alpha] induction of chemokine gene expression *involves* differential activation of and NF-kappa B1 . Regulation TNF RELA 12115625 964239 As chemokines are important for the progress of an inflammatory response by the recruitment of immuno-competent cells , the role *plays* in [TNFalpha-] or lipopolysaccharides (LPS) induced chemokine secretion by human monocyte derived macrophages was examined . Regulation TNF RELA 12133965 967045 Mitogen activated protein kinases and are *involved* in [TNF-alpha] responses to group B streptococci . Regulation TNF RELA 12133965 967053 Here we investigate the *role* of mitogen activated protein kinases ( MAPKs ) and in [TNF-alpha] production by human monocytes stimulated with GBS or LPS , used as a positive control . Regulation TNF RELA 12161100 971871 Expression of [TNF-alpha] and IL-6 was *regulated* by a transcription factor , . Regulation TNF RELA 12181188 977491 Addition of Fe2+ but not Fe3+ ( approximately 5-50 microM ) to cultured rat Kupffer cells increased TNF-alpha release and [TNF-alpha] promoter activity in a *dependent* manner . Regulation TNF RELA 12203103 983121 The *role* of in enhancement of [TNF-alpha] production was confirmed in experiments in which MG132 , an inhibitor of NF-kappaB activation , reversed the effect of AdAMP . Regulation TNF RELA 12543078 1028752 Together , the p43 induced [TNF] production was *controlled* by , p38 MAPK , and ERK that is dependent on the activities of PLC and PKC . Regulation TNF RELA 12815041 1120757 Stimulation of macrophages with GPIs of T. gondii results in activation of the transcription factor NF-kappa B , which is inhibited by the chemically synthesized GPIb , suggesting the *involvement* of in [TNF alpha] gene expression . Regulation TNF RELA 12874341 1115083 Activation of and AP-1 by P. aeruginosa GLP may be *involved* not only in [TNF-alpha] induction but also in many of the inflammatory responses triggered in the course of infection with P. aeruginosa . Regulation TNF RELA 12885587 1116718 It is concluded that T ( 3 ) -induced oxidative stress enhances the DNA binding activity of NF-kappaB and the *dependent* expression of [TNF-alpha] and IL-10 genes . Regulation TNF RELA 12957294 1137885 Moreover , the iron treatment increased TNF-alpha release and [TNF-alpha] promoter activity in a *dependent* manner . Regulation TNF RELA 14575704 1156227 dependent *regulation* of [tumor necrosis factor-alpha] gene expression by CpG-oligodeoxynucleotides . Regulation TNF RELA 14646597 1173173 is *involved* in the [TNF-alpha] induced inhibition of the differentiation of 3T3-L1 cells by reducing PPARgamma expression . Regulation TNF RELA 14736953 1199598 We investigated the *role* of and AP-1 in [tumour necrosis factor alpha (TNF-alpha)] induced monocyte chemoattractant protein 1 ( MCP-1 ) production in cultured human glomerular endothelial cells ( HGEC ) . Regulation TNF RELA 14996411 1216227 These results indicate that *plays* a potential role in the induction of NO and [TNF-alpha] by oligochitosan in macrophages . Regulation TNF RELA 15016878 1220933 Moreover , MVA/K1L gained the ability to repress artificially contrived and natural *regulated* expression of a transfected luciferase and the cellular [tumor necrosis factor] gene , respectively . Regulation TNF RELA 15062645 1230789 TNF transcripts are expressed in both mammals and fish with similar kinetics , and the *involvement* of in [TNF] expression in fish suggests that transcriptional regulation may be similar within vertebrates . Regulation TNF RELA 15265367 1275311 The *results* of EMSA showed that activation by [TNF-alpha] in HL-60 cells was induced in a dose dependent manner , but was almost completely inhibited by mutant IkappaBalpha repressor in transfected cells . Regulation TNF RELA 15464079 1305009 Anti-inflammatory drugs and [tumor necrosis factor-alpha] production from monocytes : *role* of transcription factor and implication for rheumatoid arthritis therapy . Regulation TNF RELA 15481297 1320377 *regulates* the expression of [TNF] . Regulation TNF RELA 15723831 1396171 *dependent* down-regulation of [tumor necrosis factor] receptor associated proteins contributes to interleukin-1 mediated enhancement of ultraviolet B-induced apoptosis . Regulation TNF RELA 15851579 1399557 [TNF-alpha] regulates expression of some of these factors in an *dependent* manner , whereas others are not influenced by NF-kappaB . Regulation TNF RELA 15980040 1465299 Taken together , these data provide compelling evidence for the *role* of signaling in [TNF-alpha] gene expression in heart and highlight the importance of this proinflammatory gene-regulatory pathway as a potential therapeutic target in the management of cytokine induced myocardial dysfunction . Regulation TNF RELA 16023083 1435124 This correlated with expression of [TNF] , IkappaBalpha , Bcl-2 , Bcl-xl , COX-2 and IL-6 , all *regulated* by . Regulation TNF RELA 16054790 1473758 These findings demonstrate that the inhibition of the LPS/rIFN-gamma induced production of NO and [TNF-alpha] by LR *involves* the inhibition of activation . Regulation TNF RELA 16112155 1546731 It is known that tightly *regulates* [TNF] transcription . Regulation TNF RELA 16116219 1449054 Such chemokine secretion is dependent , likely to involve AP-1 , and is *regulated* in a paracrine loop by monocyte derived [TNF-alpha] . Regulation TNF RELA 16125268 1454433 Intracellular distribution of decoy and its inhibitory *effect* on [TNFalpha] production by LPS stimulated RAW 264.7 cells . Regulation TNF RELA 16135673 1450330 Recently , we demonstrated that 3,3',5-triiodothyronine ( T3 ) induces oxidative stress in rat liver , with enhancement in the DNA binding of nuclear factor-kappaB (NF-kappaB) and the *dependent* expression of [tumor necrosis factor-alpha (TNF-alpha)] . Regulation TNF RELA 16177323 1458147 Our data indicate that the increased Ets/Elk and promoter activities associated with M. smegmatis infected macrophages are *responsible* , at least in part , for the increased [TNF-alpha] and NOS2 production observed in these infected cells and that ERK1/2 is required for Ets/Elk activity and full TNF-alpha production . Regulation TNF RELA 16357489 1519420 The inhibitory effect of DAAE on the [TNF-alpha] and IL-6 expression was *dependent* . Regulation TNF RELA 16580131 1562451 Taken together , these results suggest that the induction of IL-1beta and [TNFalpha] in endotoxin stimulated microglia is differentially *regulated* at the level of activation . Regulation TNF RELA 16581782 1543859 Gene expression analysis revealed that ER stress induced expression of [tumor necrosis factor alpha (TNF-alpha)] was IRE1alpha and *dependent* . Regulation TNF RELA 16705808 1496609 DEP induced [TNF-alpha] gene expression is *regulated* at the transcriptional level by . Regulation TNF RELA 16873280 1593287 Rhinovirus replication in human macrophages induces *dependent* [tumor necrosis factor] alpha production . Regulation TNF RELA 16888021 1596852 We found that LPS induced activation of , a *regulator* of [TNF-alpha] , was inhibited by both ethanol treatment and HO-1 activation , but the ethanol induced inhibition of NF-kappaB was HO-1 independent . Regulation TNF RELA 17041226 1631073 Human cytomegalovirus IE86 attenuates virus- and [tumor necrosis factor] alpha induced *dependent* gene expression . Regulation TNF RELA 17240450 1696449 Our studies using human U937 promonocytes cells suggested that magnolol , a low molecular weight lignan isolated from the medicinal plant Magnolia officinalis , differentially down-regulated the pharmacologically induced expression of *regulated* inflammatory gene products MMP-9 , IL-8 , MCP-1 , MIP-1alpha , [TNF-alpha] . Regulation TNF RELA 17312171 1699704 rCD40L synergized with HIV-1 Tat to increase [TNF-alpha] release from primary human monocytes and microglia , in an *dependent* manner . Regulation TNF RELA 17434489 1729016 We also observed that is *involved* in AGE-BSA induced [TNF-alpha] . Regulation TNF RELA 17485788 1739224 We postulate that green tea polyphenols *regulate* [TNF-alpha] gene expression by modulating activation through their inhibition effect on IKB Kinase (IKK) activity and as scavenger of free radicals . Regulation TNF RELA 17828497 1795612 To investigate the *role* of in [TNF-alpha] induced apoptosis in HSC-T6 , a mutant IkappaBalpha was transfected into HSC-T6 cells by lipofectin transfection technique and its transient effect was examined 48 h after the transfection . Regulation TNF RELA 17934460 1819724 Using genetic and molecular approaches , we show that Birc2 positively *regulates* the formation of the [TNF] receptor complex I in endothelial cells , thereby promoting activation and maintaining vessel integrity and stabilization . Regulation TNF RELA 18025177 1827648 In this study , we demonstrate that PECAM-1 ligation with CD38-Fc fusion protein negatively *regulates* LPS induced proinflammatory cytokine [TNF-alpha] , IL-6 , and IFN-beta production by inhibiting JNK , , and IFN regulatory factor 3 activation in macrophages . Regulation TNF RELA 18393939 1913460 In conclusion , we find that can *regulate* basal [TNFalpha] and , in certain circumstances , the hypoxia induced HIF-1alpha . Regulation TNF RELA 18832697 1971197 Glucocorticoid induced [TNF] receptor expression by T cells is reciprocally *regulated* by and NFAT . Regulation TNF RELA 19023660 2035114 This study examines the *role* of in the regulation of [TNFalpha] production by morphine in microglia . Regulation TNF RELA 19096114 2003931 To test this hypothesis , we studied the effect of CoQ10 on the *dependent* pro-inflammatory cytokine [TNF-alpha] . Regulation TNF RELA 19118493 2019358 AGEs ( advanced glycation end-products ) /RAGE ( receptor for AGEs ) , LOX-1 [ lectin-like oxidized low-density lipoprotein receptor-1 ) and ( nuclear factor kappaB ) signalling *play* key roles in [TNF-alpha] expression through an increase in circulating and/or local vascular TNF-alpha production . Regulation TNF RELA 19287189 2046627 Taken together , our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via *dependent* mechanisms as well as Tat induced [TNF-alpha] production in astrocytes . Regulation TNF RELA 19299582 2064133 Taken together , our findings suggest that signaling is *involved* in regulating LPS- and metabolites-of-ethanol mediated [TNF-alpha] production in rat Kupffer cells and in murine macrophages . Regulation TNF RELA 19326995 2052541 To investigate the underlying mechanism ( s ) for the increased TNF-alpha expression , the role of , an important *regulator* of [TNF-alpha] gene transcription , was examined . Regulation TNF RELA 19487969 2185522 Ron receptor tyrosine kinase negatively *regulates* [TNFalpha] production in alveolar macrophages by inhibiting activity and Adam17 production . Regulation TNF RELA 19596777 2122962 These results suggest that GSK-3beta *regulates* heat inactivated S. aureus induced [TNF-alpha] and NO production in microglia mainly by activating and probably by inhibiting IL-10 . Regulation TNF RELA 19721818 2133741 In vitro studies with the ester dimethyl fumarate ( DMF ) described an inhibitory effect on *dependent* transcription of [tumor necrosis factor-alpha (TNF-alpha)] induced genes in human endothelial cells . Regulation TNF RELA 20039412 2192621 *Involvement* of MAPKs and in [tumor necrosis factor] alpha induced vascular cell adhesion molecule 1 expression in human rheumatoid arthritis synovial fibroblasts . Regulation TNF RELA 20049872 2200697 In this study , we determined the effect of TNF-alpha on osteogenic differentiation of stromal cells derived from human adipose tissue ( hADSC ) and the *role* of activation on [TNF-alpha] activity . Regulation TNF RELA 20220144 2249416 We demonstrated previously that the gene encoding NGAL ( LCN2 ) is strongly up-regulated by interleukin (IL)-1beta in an *dependent* manner but not by [tumor necrosis factor (TNF)-alpha] , another potent activator of NF-kappaB . Regulation TNF RELA 20356387 2255201 Moreover , we explored the mechanism governing the expression of ATX in hepatoma cells and established a critical *role* of in basal and [TNF-alpha] induced ATX expression . Regulation TNF RELA 2555174 120829 This strongly suggests that induction of an activity is *responsible* for [TNF-alpha] stimulation of mouse MHC class I genes . Regulation TNF RELA 7608567 311961 These results indicate that superantigen induces NF-kappa B in human monocytic cells and suggest that binding of to the kappa 3 site of the TNF-alpha promoter *plays* an important role in the transcriptional activation of the [TNF-alpha] gene by superantigen . Regulation TNF RELA 7635431 317124 Using primary cultures of rat Kupffer cells the *role* of and activator protein 1 (AP-1) in the expression of the [tumor necrosis factor-alpha (TNF-alpha)] gene by lipopolysaccharide (LPS) was investigated . Regulation TNF RELA 7635431 317128 The results indicate a direct *participation* of in the regulation of [TNF-alpha] synthesis and a differential effect of LPS on NF-kappa B and AP-1 , respectively . Regulation TNF RELA 7913275 262074 HIV-1 expression was activated from J delta K cells by treatment with phorbol myristate acetate ( PMA ) , sodium butyrate ( NaB ) , or hexamethylene bisacetamide ( HMBA ) , but not tumor necrosis factor alpha (TNF-alpha) , confirming the *role* of in mediating [TNF-alpha] induction of HIV transcription . Regulation TNF RELA 8632999 361585 CNI-1493 blocked neither the lipopolysaccharide (LPS) induced increases in the expression of TNF mRNA nor the translocation of nuclear factor NF-kappa B to the nucleus in macrophages activated by 15 min of LPS stimulation , indicating that CNI-1493 does not interfere with early transcriptional *regulation* of [TNF] . Regulation TNF RELA 8798400 381447 These results indicate that TNF-alpha induced [TNF-alpha] gene expression in astrocytes *involves* p50 and p65 proteins binding to downstream NF-kappaB sites and concomitant modulation of the chromatin structure . Regulation TNF RELA 8849369 359037 Our results suggest that *plays* a pivotal role in synovial cell activation by [TNFalpha] . Regulation TNF RELA 8900181 393441 Synergistic activation of interleukin-8 gene transcription by all-trans-retinoic acid and [tumor necrosis factor-alpha] *involves* the transcription factor . Regulation TNF RELA 9079634 420548 *Role* of in [tumor necrosis factor-alpha] and interleukin-1beta regulation . Regulation TNF RELA 9366558 466092 Transcriptional control of the [TNF alpha] gene is *regulated* by the . Regulation TNF RELA 9486215 488325 In the present study , electrophoretic mobility shift assays ( EM-SAs ) and pyrrolidine dithiocarbamate ( PDTC ) , an inhibitor of NF-kappa B activation , were utilized to determine the *role* of activation in TPA and [TNF-alpha] inhibition of the surfactant proteins in NCI-H441 cells . Regulation TNF RELA 9581775 503484 The protective *role* of in blocking [TNFalpha-] and HIV-1 induced apoptosis was supported by studies in Jurkat T cells engineered to express IkappaB alpha repressor mutants ( TD-IkappaB ) under the control of a tetracycline-responsive promoter . Regulation TNF RELA 9603479 506810 IL-10 mediated suppression of [TNF-alpha] production is *independent* of its ability to inhibit activity . Regulation TNF RELA 9794408 542965 Our results demonstrate that a novel nuclear binding activity *plays* an important role in regulation of the rapid and transient transcriptional activation of the [TNF-alpha] gene via Fc epsilonRI . Regulation TNF RELA 9868178 556542 We postulated that green tea polyphenols *regulate* [TNFalpha] gene expression by modulating activation through their antioxidant properties . Regulation TNF RELA 9916895 559062 We determined that binding sites for both ( -186 bp region ) and C/EBP ( -198 bp region ) are *involved* in [TNF-alpha] and IL-1beta mediated ICAM-1 upregulation . Regulation TNF RELB 20686703 2299247 We conclude that *regulates* [TNFalpha] cytokine synthesis by competitive interference binding with RelA , which leads to downregulation of TNFalpha production . Regulation TNF RELB 23394901 2755040 *regulates* [TNF] production in LPS stimulated dendritic cells and macrophages . Regulation TNF RENBP 1762301 174673 These findings suggest that may be *involved* in the production of [TNF] and IL-1 from M phi . Regulation TNF RETN 22464705 2578546 [ The *effect* of on nuclear factor-kB and [tumor necrosis factor-a] expression in hepatic steatosis ] . Regulation TNF RGL1 19627007 2112735 [ *Effect* of ginsenoside on the expression of [TNF-alpha] and MCP-1 in rats with diabetic nephropathy ] . Regulation TNF RGL1 19627007 2112743 To investigate the *effects* of Ginsenoside on proteinuria and the expression of monocyte chemotactic protein-1 (MCP-1) and [tumor necrosis factor-alpha (TNF-alpha)] in rats with diabetic nephropathy (DN) . Regulation TNF RGL2 19627007 2112738 [ *Effect* of ginsenoside on the expression of [TNF-alpha] and MCP-1 in rats with diabetic nephropathy ] . Regulation TNF RGL2 19627007 2112746 To investigate the *effects* of Ginsenoside on proteinuria and the expression of monocyte chemotactic protein-1 (MCP-1) and [tumor necrosis factor-alpha (TNF-alpha)] in rats with diabetic nephropathy (DN) . Regulation TNF RGL3 19627007 2112736 [ *Effect* of ginsenoside on the expression of [TNF-alpha] and MCP-1 in rats with diabetic nephropathy ] . Regulation TNF RGL3 19627007 2112744 To investigate the *effects* of Ginsenoside on proteinuria and the expression of monocyte chemotactic protein-1 (MCP-1) and [tumor necrosis factor-alpha (TNF-alpha)] in rats with diabetic nephropathy (DN) . Regulation TNF RGL4 19627007 2112737 [ *Effect* of ginsenoside on the expression of [TNF-alpha] and MCP-1 in rats with diabetic nephropathy ] . Regulation TNF RGL4 19627007 2112745 To investigate the *effects* of Ginsenoside on proteinuria and the expression of monocyte chemotactic protein-1 (MCP-1) and [tumor necrosis factor-alpha (TNF-alpha)] in rats with diabetic nephropathy (DN) . Regulation TNF RHO 17762807 1790224 Furthermore , it is thought that is *involved* in [TNF-alpha] and interleukin (IL) production in the central nervous system , and the production was inhibited by administering Rho kinase inhibitor in the central nervous system . Regulation TNF RHO 20593289 2296394 Moreover , these findings show that signalling *regulates* [TNF-alpha] and CXC chemokine formation as well as lipid peroxidation in the reperfused colon . Regulation TNF RHOB 22869204 2775112 These results demonstrated that LPS induced RhoB expression in mouse in vivo and in vitro and in RAW264.7 cells , and the *role* of on LPS induced secretion of [TNF-a] and NO was at least partly mediated via NF-?B . Regulation TNF RIPK1 19927158 2203741 To determine the *role* of in [TNF/IAP] antagonist induced death , we compared wild type ( WT ) and RIPK1 ( -/- ) mouse embryonic fibroblasts ( MEFs ) treated with these compounds . Regulation TNF RNASE3 17234454 1703900 The *effect* of on serum [TNF-a] level in chronic graft versus host disease ( GvHD ) . Regulation TNF RNASE3 17234454 1703901 The aim of this study was to evaluate whether there was any relation between serum [TNF-a] levels and the *response* to in patients with steroid refractory of extensive chronic GvHD . Regulation TNF RNF103 18768892 1957249 Consistently , Nod2-null macrophages tolerant to LPS and MDP showed enhanced production of [TNF-alpha] and IL-6 as well as increased NF-kappaB and MAPK activation in *response* to the dipeptide , the Nod1 agonist . Regulation TNF RPIA 8505858 221400 The *effect* of on [TNF] was in part abolished by the antagonist 8-sulfophenyltheophylline . Regulation TNF RPTOR 22351078 2561126 The aim of this study was to investigate the *role* of in myocardial [TNF-a] expression during endotoxemia . Regulation TNF S100A12 14636837 1171329 In this study , the *effects* of neuropeptides substance P ( SP ) and on production of pro-inflammatory cytokines [TNF] and IL-1 beta by macrophages were considered . Regulation TNF S100A12 19299480 2106079 In the present study , we demonstrate that is *involved* in morphine tolerance by differentially regulating the ERK dependent up-regulation of IL-1beta , [TNF-alpha] , and microsomal prostaglandin E synthase-1 ( mPGES-1 ) in astrocytes and p38 dependent up-regulation of IL-6 in microglia in the rat spinal cord . Regulation TNF S100A12 23958840 2850323 In this study we used a keratinocyte cell line to identify the presence of substance P ( SP ) and calcitonin gene related peptide (CGRP) receptors on keratinocytes and examined the *effects* of SP and stimulation on keratinocyte neuropeptide signaling , cell proliferation , and interleukin-1ß (IL-1ß) , interleukin-6 (IL-6) , [tumor necrosis factor a (TNF-a)] , and nerve growth factor (NGF) expression . Regulation TNF S100A12 9417811 472229 Since CGRP was shown to inhibit TNF-alpha production by T cells and stimulate IL-6 expression by fibroblasts , this study was designed to investigate whether *regulated* [TNF-alpha] and IL-6 production by osteoblasts . Regulation TNF S100B 16376947 1547169 Moreover , additional studies demonstrated that *affected* also [TNF-alpha] protein expression in J774 macrophages . Regulation TNF S100B 23755753 2797806 Soluble RAGE ( sRAGE ) reduced *dependent* secretion of [TNF-alpha] but did not decrease S100B dependent secretion of IL-6 . Regulation TNF SAA1 10679217 668841 This study focuses on the *effect* of AI , , and HDL from healthy ( N-HDL ) and acute phase individuals ( AP-HDL ) on the release of [TNF-alpha] , IL-1beta , and IL-8 by human blood neutrophils . Regulation TNF SAA1 22076945 2574652 Acute-phase *regulates* [tumor necrosis factor] a and matrix turnover and predicts disease progression in patients with inflammatory arthritis before and after biologic therapy . Regulation TNF SAA2 22076945 2574653 Acute-phase *regulates* [tumor necrosis factor] a and matrix turnover and predicts disease progression in patients with inflammatory arthritis before and after biologic therapy . Regulation TNF SAA4 22076945 2574654 Acute-phase *regulates* [tumor necrosis factor] a and matrix turnover and predicts disease progression in patients with inflammatory arthritis before and after biologic therapy . Regulation TNF SACM1L 12022753 943291 Although PTK was the predominant signaling pathway , inhibition of PTP only partially restored the [TNF-alpha] *response* to . Regulation TNF SCG2 19115042 2024899 The *effect* of on [TNF-alpha] production was partially inhibited by CRDO . Regulation TNF SCG2 7542064 310915 The inhibitory *effect* of and NED on [TNF-alpha] release from MCs may explain some of their anti-inflammatory and therapeutic effects . Regulation TNF SCG3 19115042 2024901 The *effect* of on [TNF-alpha] production was partially inhibited by CRDO . Regulation TNF SCG3 7542064 310917 The inhibitory *effect* of and NED on [TNF-alpha] release from MCs may explain some of their anti-inflammatory and therapeutic effects . Regulation TNF SCG5 19115042 2024900 The *effect* of on [TNF-alpha] production was partially inhibited by CRDO . Regulation TNF SCG5 7542064 310916 The inhibitory *effect* of and NED on [TNF-alpha] release from MCs may explain some of their anti-inflammatory and therapeutic effects . Regulation TNF SDHD 11355520 815429 This increase in TNF production suggests that *plays* a role in the induction of [TNF] during the natural infection . Regulation TNF SDHD 11355520 815430 In addition , the modulatory *effect* of on [TNF] release by THP-1 cells reinforces that monocytes are one of the possible targets of this molecule . Regulation TNF SDHD 18700620 1950362 This increase in TNF-alpha production suggests that may *play* a significant role in the induction of [TNF-alpha] during natural infection . Regulation TNF SEA 18285496 1896488 [Tumor necrosis factor] alpha levels in *response* to stimulation with were high , and a negative association between presentation with hepatomegaly and the levels of the regulatory cytokines interleukin-6 and transforming growth factor beta(1) suggests that a possible mechanism for childhood hepatomegaly in areas where both malaria and schistosomiasis are endemic is poor regulation of an inflammatory response to schistosome eggs . Regulation TNF SEA 19375418 2081814 Increased production of [TNF-alpha] and IL-1 in alveolar macrophages was observed in *response* to and SEB . Regulation TNF SELE 22996381 2740301 Curcumin *regulates* the expression of inflammatory cytokines ( e.g. , [TNF] , IL-1 ) , growth factors ( e.g. , VEGF , EGF , FGF ) , growth factor receptors ( e.g. , EGFR , HER-2 , AR ) , enzymes ( e.g. , COX-2 , LOX , MMP9 , MAPK , mTOR , Akt ) , adhesion molecules ( e.g. , , ICAM-1 , VCAM-1 ) , apoptosis related proteins ( e.g. , Bcl-2 , caspases , DR , Fas ) , and cell cycle proteins ( e.g. , cyclin D1 ) . Regulation TNF SELP 17255363 1732916 Interference with decreased endotoxin mediated hepatocellular apoptosis and necrosis , but did not *affect* hepatic levels of [tumor necrosis factor-alpha] and CXC chemokines . Regulation TNF SELP 23018521 2726850 The secretion of [tumor necrosis factor (TNF)-a] , interleukin (IL)-1ß , IL-6 , IL-8 , IL-12 and macrophage inflammatory protein-1ß increased 3- to 10-fold in *response* to compared with unstimulated monocytes . Regulation TNF SERPINC1 11798464 892479 *Effects* of on [tumor necrosis factor-alpha] and interleukin-1beta synthesis in vascular smooth muscle cells . Regulation TNF SETBP1 11141330 770184 The induced [TNF] *response* in vitro and in vivo was stronger in resistant B10 .BR mice than in susceptible C3H/HeJ mice . Regulation TNF SETBP1 11442023 833494 All monkeys made IL-2 , [TNF] , and IFN-gamma in *response* to . Regulation TNF SETBP1 12230915 988349 Peritoneal macrophages from C3H/HeJ mice did not produce [TNF-alpha] in vitro in *response* to or LPS . Regulation TNF SETBP1 7520469 266312 In vitro experiments indicated that NO synthase (NOS) inhibition by N-nitro-L-arginine methyl ester ( L-NAME ) enhanced IFN-gamma and [TNF] production by splenocytes in *response* to . Regulation TNF SETBP1 8299910 248601 The results show that SEB contributes to lethal shock associated with severe hepatic injury in GalN sensitized mice and suggest that [TNF-alpha] and IFN-gamma produced in *response* to may be mediators of the lethal toxicity and hepatotoxicity of SEB . Regulation TNF SETBP1 8960643 402281 In *response* to , patients with sepsis and patient with septic shock demonstrated significantly decreased release of [TNF-alpha] and IL-1beta . Regulation TNF SETBP1 9916683 587474 [TNF-alpha] production by peripheral T cells in *response* to and anti-CD28 mAb correlated more closely with ERK activity than with p38 activity . Regulation TNF SETD2 11576469 865153 Hypoxic upregulation of [TNF] receptor type 2 expression involves NF-IL-6 and is *independent* of or HIF-2 . Regulation TNF SETD2 23085511 2698947 In this study , we investigated direct effects of hypoxia on TNF-a expression of cardiomyocytes , the *role* of in [TNF-a] regulation and potential secretory pathway of TNF-a . Regulation TNF SIRT1 19151729 2032292 Intracellular NAD levels regulate [tumor necrosis factor] protein synthesis in a *dependent* manner . Regulation TNF SIRT1 19299582 2064130 In the present study , we examined the *role* of signaling in [TNF-alpha] generation stimulated by either lipopolysaccharide (LPS) , acetaldehyde (AcH) , or acetate ( two major metabolites of ethanol ) in two cultured macrophage cell lines . Regulation TNF SIRT1 19299582 2064131 Taken together , our findings suggest that signaling is *involved* in regulating LPS- and metabolites-of-ethanol mediated [TNF-alpha] production in rat Kupffer cells and in murine macrophages . Regulation TNF SIRT1 19996381 2210444 We also demonstrate that SIRT1 activators inhibit LPS stimulated inflammatory pathways , as well as secretion of [TNFalpha] , in a *dependent* manner in RAW264.7 cells and in primary intraperitoneal macrophages . Regulation TNF SIRT2 19151729 2032291 Intracellular NAD levels regulate [tumor necrosis factor] protein synthesis in a *dependent* manner . Regulation TNF SIRT3 19151729 2032293 Intracellular NAD levels regulate [tumor necrosis factor] protein synthesis in a *dependent* manner . Regulation TNF SIRT4 19151729 2032294 Intracellular NAD levels regulate [tumor necrosis factor] protein synthesis in a *dependent* manner . Regulation TNF SIRT5 19151729 2032295 Intracellular NAD levels regulate [tumor necrosis factor] protein synthesis in a *dependent* manner . Regulation TNF SIRT6 19151729 2032296 Intracellular NAD levels regulate [tumor necrosis factor] protein synthesis in a *dependent* manner . Regulation TNF SIRT6 23552949 2767253 *regulates* [TNF-a] secretion through hydrolysis of long-chain fatty acyl lysine . Regulation TNF SIRT7 19151729 2032297 Intracellular NAD levels regulate [tumor necrosis factor] protein synthesis in a *dependent* manner . Regulation TNF SKP1 11339505 812225 In the present study we investigated the *effect* of and/or IgE on histamine , [TNF-alpha] and chemokines released from bone marrow derived mast cells ( BMMC ) as well as chemokine receptor expression . Regulation TNF SKP1 8809429 383144 Changes in the level of mastocytoma mRNA for [TNF alpha] in *response* to stimulation with or fibroblast conditioned media for up to 12 weeks were studied using Northern analysis and changes in the level of TNF alpha protein expression on immunoblot and immunocytochemistry . Regulation TNF SKP1 9858520 555644 Repetitive administration of SCF also can enhance survival in mice that genetically lack tumor necrosis factor (TNF)-alpha , demonstrating that the ability of SCF treatment to improve survival after CLP does not solely reflect *effects* of on mast cell- dependent ( or -independent ) production of [TNF-alpha] . Regulation TNF SLAMF1 15123745 1242413 Although *controls* production of IL-12 , [tumor necrosis factor] , and nitric oxide in response to lipopolysaccharide (LPS) by macrophages , SLAM does not regulate phagocytosis and responses to peptidoglycan or CpG . Regulation TNF SLC17A5 12766075 1094146 In addition , the *effect* of on endotoxin induced nitric oxide ( NO ) , prostaglandin E2 ( PGE2 ) , and [tumor necrosis factor (TNF)-alpha] production in a mouse macrophage cell line ( RAW 264.7 ) was studied in vitro . Regulation TNF SLC25A16 19403166 2089550 The *effect* of ( OH ) 22 nanoparticles on the release of Th1/Th2 cytokines and induction of [TNF-alpha] mediated cellular immunity . Regulation TNF SLC33A1 16755007 1571601 These results suggest that the up-regulation of cardiac B2-receptor expression by LPS is mediated through [TNF-alpha] , which is produced in the myocardium by two different mechanisms in an *dependent* and independent manners , implying the role of the cardiac kallikrein-kinin system in the development of cardiac dysfunction during sepsis . Regulation TNF SLPI 10481411 643694 In this study , we examined the *effects* of on the production of a proinflammatory cytokine , [TNF-alpha] , and immunosupressive cytokines , IL-10 and transforming growth factor-beta ( TGF-beta ) by macrophages ( M phi s ) , in response to lipopolysaccharide (LPS) mediated stimulation and M. avium complex ( MAC ) infection , using recombinant half sized SLPI ( 1/2 SLPI ) consisting of C-terminal domain ( Arg55-Ala107 ) of intact SLPI . Regulation TNF SLPI 10481411 643696 In both cases , 1/2 did not *affect* the LPS- or MAC induced [TNF-alpha] production by M phi s . Regulation TNF SLPI 12668158 1075711 *Effects* of on the [tumor necrosis factor-alpha] production and NF-kappaB activation of lipopolysaccharide stimulated macrophages . Regulation TNF SLPI 12668158 1075714 We thus examined the *effects* of on the [TNF-alpha] production by LPS stimulated Mphis . Regulation TNF SMARCA4 19556365 2117149 Here , we examined the *role* of , a chromatin remodeling enzyme , in the transcription of [TNF-alpha] and MCP-1 in response to renal ischemia . Regulation TNF SMPD1 20236926 2272973 Studies on the *role* of and ceramide in the regulation of tumor necrosis factor alpha (TNFalpha) converting enzyme activity and [TNFalpha] secretion in macrophages . Regulation TNF SMPD2 11311151 804936 These results suggest that ( part of ) the presently identified caveolar activity is *involved* in [TNFalpha] signalling . Regulation TNF SMPD2 16269668 1502356 Inhibition of inhibited Sph1P formation , whereas inhibition of SK1 did not *affect* N-SMase2 activation by [TNF-alpha] . Regulation TNF SMPD2 17085432 1675744 *Role* for in [tumor necrosis factor] alpha stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells : p38 MAPK is an upstream regulator of nSMase2 . Regulation TNF SMPD2 7507110 244525 We found that [TNF-alpha] signaling may *involve* activation of a cell membrane in that within 2.5-5 min of treatment of cells with TNF-alpha there was a 2-fold increase in the activity of N-SMase compared to control . Regulation TNF SNAP25 9038216 415426 However , SNP and did not elevate cGMP levels in U937 cell cultures , and the cGMP analog , 8-bromo-cGMP , had no *effect* on [TNF] production . Regulation TNF SNN 16572589 1543282 In order to assess how may be *involved* in [TNF-alpha] signaling in HUVEC growth arrest , we performed microarray analysis of TNF-alpha stimulated HUVECs with and without Snn knockdown via siRNA . Regulation TNF SNORD20 22896603 2682845 is *responsible* for human herpesvirus 6B inhibition of [tumor necrosis factor] receptor dependent signaling and apoptosis . Regulation TNF SNORD50A 8996182 409650 , a selective kappa opioid receptor agonist , did not *affect* the LPS induced production of NO or [TNF-alpha] . Regulation TNF SOCS1 12032139 968177 Therefore , these findings provide evidence that physiological levels of negatively *regulate* [TNF] signaling . Regulation TNF SOCS1 20406299 2300594 We investigated whether the early induction of by IL-4 was *responsible* for the suppression of LPS induced [tumour necrosis factor (TNF)-alpha] production by IL-4 . Regulation TNF SOCS1 20406299 2300598 These data suggest that is not *involved* in the suppression of LPS induced [TNF-alpha] production by IL-4 . Regulation TNF SOCS3 16925527 1603316 Physiological levels of detected in IL-10 exposed human monocytes had no *effect* on LPS induced [TNF-alpha] production . Regulation TNF SOCS3 23129128 2751167 RNA interference assay and luciferase assay showed that was *responsible* for the down-regulation of [TNF-a] by KBP , rather than NF-?B subunit p65 and ß-catenin . Regulation TNF SOST 22923429 2837628 Studies assessing mechanisms of estrogen action on bone in humans have identified effects of estrogen on RANKL expression by several different cell types in the bone microenvironment , a *role* for [TNF-a] and IL-1ß in mediating effects of estrogen deficiency on bone , and possible regulation of the Wnt inhibitor , , by estrogen . Regulation TNF SP1 21320120 2410706 Therefore , we initially speculated that miR-1224 was a negative regulator of [TNF-a] in an *dependent* manner , which was confirmed in vivo by chromatin immunoprecipitation assay , and might be involved in regulating the LPS mediated inflammatory responses . Regulation TNF SP100 12773323 1113388 In contrast , [tumor necrosis factor-alpha] production induced by a lipopeptide , and nitric oxide production induced by picolinic acid , were not *affected* by . Regulation TNF SP4 7497530 335853 Separated mononuclear cells also produced significant levels of [TNF] in *response* to SP and . Regulation TNF SPHK1 20577214 2280427 These results also highlight the key *role* of and its product S1P in [TNF-alpha] signalling and the canonical NF-kappaB activation pathway important in inflammatory , antiapoptotic and immune processes . Regulation TNF SPOP 19164706 2038387 In humans , we found that *plays* a conserved role in [TNF] mediated JNK signaling and was highly expressed in 99 % of clear cell renal cell carcinomas ( RCCs ) , the most prevalent form of kidney cancer . Regulation TNF SPP1 17444956 1729825 The in vitro *effect* of stimulation on T-cell IFN-gamma , [TNF-alpha] , and IL-10 production was measured . Regulation TNF SPP1 23416968 2748874 Using neutralizing antibody and recombinant cytokines , we found that overexpressed by tumor cells *regulates* the production of [TNF-a] and IL-10 by monocytes partly via MCP-1 and TGF-ß1 , respectively . Regulation TNF SPP1 9324065 456616 Moreover , had a significant *effect* on anti-DNP IgE induced histamine release or [tumor necrosis factor-alpha] production from RPMC . Regulation TNF SPP2 9324065 456617 Moreover , had a significant *effect* on anti-DNP IgE induced histamine release or [tumor necrosis factor-alpha] production from RPMC . Regulation TNF SQSTM1 11438547 843382 Although the *role* of receptor in [TNF] signaling is well established , the role of p80 is less clear . Regulation TNF SQSTM1 20337701 2273167 Mouse macrophage RAW264.7 cells produced [tumor necrosis factor (TNF)-alpha] in *response* to stimulation with recombinant . Regulation TNF SRC 15869794 1497484 Lipopolysaccharide induced expression *plays* a role in nitric oxide and [TNFalpha] secretion in macrophages . Regulation TNF SRC 17934341 1813490 These results indicate that [TNF-alpha] production by TCDD in differentiated THP-1 macrophages is AhR dependent and *involves* activation of EGFR and ERK , but not , JNK , nor p38 MAPK . Regulation TNF SRC 23639811 2805067 Hepatocytes produce [TNF-a] following hypoxia-reoxygenation and liver ischemia-reperfusion in a NADPH oxidase- and *dependent* manner . Regulation TNF SRC 23639811 2805069 We now extend these studies into mouse models to evaluate the contribution of hepatocytes to the NOX- and *dependent* [TNF-a] production that follows H/R in primary hepatocytes and liver ischemia-reperfusion ( I/R ) . Regulation TNF SRL 17498286 1744458 Part I of the study investigated in cytoflow studies the *effect* of ( 0.01-1000 ng/ml ) on [TNF-alpha] induced expression of intercellular adhesion molecule 1 ( ICAM-1 ) in human coronary endothelial cells ( HCAEC ) and human coronary smooth muscle cells ( HCMSMC ) . Regulation TNF SRP14 19228095 2039924 and PDT had similar *effects* on crevicular [TNF-alpha] and RANKL levels in patients with aggressive periodontitis . Regulation TNF SRP19 19228095 2039925 and PDT had similar *effects* on crevicular [TNF-alpha] and RANKL levels in patients with aggressive periodontitis . Regulation TNF SRP54 19228095 2039926 and PDT had similar *effects* on crevicular [TNF-alpha] and RANKL levels in patients with aggressive periodontitis . Regulation TNF SRP68 19228095 2039927 and PDT had similar *effects* on crevicular [TNF-alpha] and RANKL levels in patients with aggressive periodontitis . Regulation TNF SRP72 19228095 2039928 and PDT had similar *effects* on crevicular [TNF-alpha] and RANKL levels in patients with aggressive periodontitis . Regulation TNF SRP9 19228095 2039929 and PDT had similar *effects* on crevicular [TNF-alpha] and RANKL levels in patients with aggressive periodontitis . Regulation TNF SST 17456366 1730196 To explore the *effect* of on serum interleukin (IL)-6 and [tumor necrosis factor (TNF)-alpha] in lipopolysaccharide (LPS) induced septic shock . Regulation TNF SST 8982099 403792 Differential *effects* of gastrin releasing peptide , neuropeptide Y , and vasoactive intestinal peptide on interleukin-1 beta , interleukin-6 and [tumor necrosis factor-alpha] production by whole blood cells from healthy young and old subjects . Regulation TNF STAP2 24733425 2939061 Intriguingly , also *regulates* production of proinflammatory chemokines and cytokines such as CXCL1 and [TNF-a] from intestinal epithelial cells . Regulation TNF STAT1 11835405 911415 Here , we report our investigation of the *role* of in [TNF] signaling using STAT1-deficient U3A and STAT1-stably transfected U3A-PSG91 cells . Regulation TNF STAT1 16635351 1552730 and STAT3 might be *involved* in the regulation of [TNF-alpha] gene expression , but not in TNF-alpha early release ( < 24 hours ) induced by HMGB1 stimulation in rat peritoneal macrophages . Regulation TNF STAT3 10616907 575887 We report that [TNF] induces DNA replication in growth arrested LE6 cells and that its effect *involves* the activation of NFkappaB and and an increase in c-myc and IL-6 mRNAs . Regulation TNF STAT3 14688368 1190738 Macrophage-specific STAT3-null mice have demonstrated that *plays* a critical role in the suppression of LPS induced [TNF-alpha] release , although the mechanism by which STAT3 mediates this inhibition is still not clear . Regulation TNF STAT3 16635351 1552731 STAT1 and might be *involved* in the regulation of [TNF-alpha] gene expression , but not in TNF-alpha early release ( < 24 hours ) induced by HMGB1 stimulation in rat peritoneal macrophages . Regulation TNF STAT3 17302908 1699002 activated by LPS did not directly *regulate* inhibitor of kappa B alpha ( IkappaBalpha ) activation or [tumour necrosis factor (TNF)-alpha] production , a process dependent on the transcriptional activity of nuclear factor kappa B (NFkappaB) , although the transcriptional activity of STAT3 contributed to the mechanism by which interleukin (IL)-10 suppressed LPS induced TNF-alpha levels . Regulation TNF STAT3 17302908 1699004 These results indicate that activation can not directly *regulate* LPS signalling in human monocytes and represents only part of the mechanism by which IL-10 suppresses [TNF-alpha] production by activated human monocytes . Regulation TNF STAT3 22506067 2583964 *regulates* monocyte [TNF-alpha] production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass . Regulation TNF STAT3 22506067 2583965 Our findings suggest that signaling *plays* a crucial role in the downregulation of [TNF-a] synthesis by human monocytes in the course of systemic inflammation in vivo . Regulation TNF STAT6 11254707 794138 [TNF-alpha] activated gene expression at the transcriptional level in a *dependent* manner , because : 1 ) eotaxin-1 promoter luciferase constructs were TNF-alpha inducible in STAT6-defective HEK293 cells only on cotransfection of STAT6 expression vector , an effect that was partially mediated by activation induced binding of NF-kappa B proteins to a composite STAT6/NF-kappa B element ; Regulation TNF STAT6 14638848 1176709 signaling induced TNF-alpha mRNA destabilization in an AU-rich element ( ARE ) -dependent manner , but did not *affect* [TNF-alpha] promoter activity . Regulation TNF STK10 10485710 644448 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Regulation TNF STK11 10485710 644449 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Regulation TNF STK16 10485710 644450 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Regulation TNF STK19 10485710 644451 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Regulation TNF STK24 10485710 644452 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Regulation TNF STK25 10485710 644453 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Regulation TNF STK3 10485710 644454 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Regulation TNF STK31 10485710 644455 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Regulation TNF STK33 10485710 644457 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Regulation TNF STK35 10485710 644458 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Regulation TNF STK36 10485710 644459 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Regulation TNF STK38 10485710 644461 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Regulation TNF STK39 10485710 644460 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Regulation TNF STK4 10485710 644456 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Regulation TNF STK40 10485710 644462 Here we show that the Akt is *involved* in the activation of NF-kappaB by [tumour necrosis factor (TNF)] . Regulation TNF STS 23064768 2827298 Data showed that overexpression induced by pEGFP-ASC-C2 transfection significantly increased caspase-1 expression and interleukin (IL)-1ß and IL-6 secretion , but did not *affect* [tumor necrosis factor (TNF)-a] secretion . Regulation TNF SULT1E1 9643476 514460 A macrophage cell line ( J774-A1 ) was used to measure the *effects* of on [tumor necrosis factor-alpha (TNF-alpha)] and interleukin-1beta (IL-1beta) secretion . Regulation TNF SYK 15240695 1270295 Whether *plays* any role in [TNF] signaling was investigated . Regulation TNF SYK 22541243 2608311 *Effects* of the inhibitors on several B-cell functions and expression of TLR9 , [TNF receptor associated factors (TRAFs)] , and phospho-nuclear factor ?B in B cells were assessed . Regulation TNF SYNCRIP 11116146 786604 NF-kappaB activation by the [tumor necrosis factor receptor (TNFR)] *involves* the formation of a termed a signalosome . Regulation TNF SYT1 15980040 1465289 Therefore , the goal of the present study was to examine the *role* of subunit phosphorylation in the regulation of [TNF-alpha] production in cultured neonatal ventricular myocytes . Regulation TNF SYT11 23303671 2737912 had a direct *effect* on phagocytosis and on the secretion of [TNF] and IL-6 . Regulation TNF TAB1 10187861 603064 Furthermore , [tumor necrosis factor-alpha] activated endogenous TAK1 , and the kinase negative *acted* as a dominant negative inhibitor against tumor necrosis factor-alpha induced NF-kappaB activation . Regulation TNF TAB1 17052891 1683808 In this study , a critical *role* for in IL-1alpha or [TNFalpha] stimulated MAPK and NFkappaB activation was confirmed by inhibition of the nuclear accumulation of NFkappaB p65 and phosphorylated forms of c-Jun and p38 following siRNA mediated TAK1 silencing . Regulation TNF TAB1 21335610 2443390 In general , crucially *regulates* IL-1 and [TNF] signalling in fibroblasts . Regulation TNF TAB2 17449468 1749609 RBCK1 negatively *regulates* [tumor necrosis factor-] and interleukin-1 triggered NF-kappaB activation by targeting for degradation . Regulation TNF TAC1 10954918 724652 Chloramphenicol acetyltransferase (CAT) activity was reduced by 22-fold , suggesting that *plays* a role in LPS induction of the [TNF-alpha] promoter . Regulation TNF TAC3 10954918 724653 Chloramphenicol acetyltransferase (CAT) activity was reduced by 22-fold , suggesting that *plays* a role in LPS induction of the [TNF-alpha] promoter . Regulation TNF TAC4 10954918 724654 Chloramphenicol acetyltransferase (CAT) activity was reduced by 22-fold , suggesting that *plays* a role in LPS induction of the [TNF-alpha] promoter . Regulation TNF TANK 10201981 605776 We concluded that is partially *involved* in [TNF-alpha] mediated signaling through I kappa B/NF-kappa B in IEC . Regulation TNF TANK 19150425 2026748 The combined data reveal that phosphorylation of *plays* a critical role in [TNF] signaling by directing the IKK complex to the membrane , promoting TRAF2 K63 linked ubiquitination , and positioning the IKKalpha and IKKbeta chains with the TAK1/TAB kinase . Regulation TNF TANK 19810754 2159675 Our structural observation should prompt a re-evaluation of the *role* of in [TNFalpha] signaling and may indicate that TRAF2 associated proteins such as cIAPs may be the ubiquitin ligases for NF-kappaB signaling . Regulation TNF TANK 19918265 2190016 Furthermore the downstream target of MLK3 , JNK was activated by [TNF-alpha] in a *dependent* manner . Regulation TNF TANK 20038584 2211146 In accord with the known inhibitory *role* of in the alternative NFkappaB pathway , TNFR2- , but not TNFR1-specific [TNF] induced depletion of cytosolic TRAF2 . Regulation TNF TAT 12504868 1037848 Moreover , synergistic *effects* of plus METH on the [tumor necrosis factor-alpha] and interleukin-1beta mRNA levels were observed in the striatal region . Regulation TNF TAT 24625401 2925475 *Effects* of HIV-1 on secretion of [TNF-a] and IL-1ß by U87 cells in AIDS patients with or without AIDS dementia complex . Regulation TNF TAT 8806505 382309 Here we show that because of this similarity of mechanisms , the expression of an RNA species encoding polymeric-TAR sequences and known to inhibit Tat mediated HIV-1 gene expression also blocks [TNF] gene expression in *response* to , but not TNF promoter activation induced by human T cell leukemia/lymphotropic virus type I Tax protein . Regulation TNF TAT 9670843 519603 *Regulation* of [TNFalpha] and TGFbeta-1 gene transcription by HIV-1 in CNS cells . Regulation TNF TAT 9671213 519801 at the same concentrations did not *affect* IL-10 , IL-6 , or [TNF-alpha] production . Regulation TNF TBL2 11783287 581341 To study the *effect* of on the proliferation of synovial fibroblast and interleukin-1 (IL-1) , [tumor necrosis factor-alpha (TNF-alpha)] and postaglandin E2 ( PGE2 ) secretion by synoviocytes in adjuvant arthritis ( AA ) rats . Regulation TNF TBL3 11783287 581342 To study the *effect* of on the proliferation of synovial fibroblast and interleukin-1 (IL-1) , [tumor necrosis factor-alpha (TNF-alpha)] and postaglandin E2 ( PGE2 ) secretion by synoviocytes in adjuvant arthritis ( AA ) rats . Regulation TNF TCF12 10200294 605486 A novel lipopolysaccharide induced *regulating* [tumor necrosis factor] alpha gene expression : molecular cloning , sequencing , characterization , and chromosomal assignment . Regulation TNF TCF12 12161100 971859 Expression of [TNF-alpha] and IL-6 was *regulated* by a , nuclear factor (NF)-kappaB . Regulation TNF TCF12 16489119 1581777 Given the fact that the nuclear factor of activated T cells ( NFAT ) *plays* an important role in the regulation of [TNF-alpha] and can also be activated by ROS , in this study we investigated the potential role of ROS in silica induced NFAT activity as well as TNF-alpha expression in Cl41 cells . Regulation TNF TCF12 18446789 1915761 This *plays* a key role in the expression of cytokines , [tumor necrosis factor alpha (TNF-alpha)] , interleukin 6 , interleukin 8 , tumor growth factor beta , and Fas ligand . Regulation TNF TCF12 18554501 1929376 Lipopolysaccharide induced TNF-alpha factor ( LITAF ) , a , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Regulation TNF TCF12 18692180 1979599 Using chemical inhibitors we show that ( i ) both ERK1/2 MAP kinase and NF-kappaB *play* an important role in IL-10 and [TNF-alpha] production , in macrophages stimulated by Tat . Regulation TNF TCF12 8046241 267006 This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity , but does not modulate activation of NF-kappa B *controlling* the expression of various [TNF-alpha-inducible] genes . Regulation TNF TCF12 8773576 379579 Finally , potential targets of *regulation* by the zinc-finger encoded by egr-1 include the interleukin-2 , CD44 , ICAM-1 , and [tumor necrosis factor] genes . Regulation TNF TCF12 9852224 554674 Altered binding of the NF-GMa is *involved* in the upregulated production of [TNF-alpha] by macrophages of mammary tumor bearing mice . Regulation TNF TCF15 10200294 605487 A novel lipopolysaccharide induced *regulating* [tumor necrosis factor] alpha gene expression : molecular cloning , sequencing , characterization , and chromosomal assignment . Regulation TNF TCF15 12161100 971860 Expression of [TNF-alpha] and IL-6 was *regulated* by a , nuclear factor (NF)-kappaB . Regulation TNF TCF15 16489119 1581778 Given the fact that the nuclear factor of activated T cells ( NFAT ) *plays* an important role in the regulation of [TNF-alpha] and can also be activated by ROS , in this study we investigated the potential role of ROS in silica induced NFAT activity as well as TNF-alpha expression in Cl41 cells . Regulation TNF TCF15 18446789 1915762 This *plays* a key role in the expression of cytokines , [tumor necrosis factor alpha (TNF-alpha)] , interleukin 6 , interleukin 8 , tumor growth factor beta , and Fas ligand . Regulation TNF TCF15 18554501 1929377 Lipopolysaccharide induced TNF-alpha factor ( LITAF ) , a , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Regulation TNF TCF15 18692180 1979600 Using chemical inhibitors we show that ( i ) both ERK1/2 MAP kinase and NF-kappaB *play* an important role in IL-10 and [TNF-alpha] production , in macrophages stimulated by Tat . Regulation TNF TCF15 8046241 267007 This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity , but does not modulate activation of NF-kappa B *controlling* the expression of various [TNF-alpha-inducible] genes . Regulation TNF TCF15 8773576 379580 Finally , potential targets of *regulation* by the zinc-finger encoded by egr-1 include the interleukin-2 , CD44 , ICAM-1 , and [tumor necrosis factor] genes . Regulation TNF TCF15 9852224 554675 Altered binding of the NF-GMa is *involved* in the upregulated production of [TNF-alpha] by macrophages of mammary tumor bearing mice . Regulation TNF TCF19 10200294 605488 A novel lipopolysaccharide induced *regulating* [tumor necrosis factor] alpha gene expression : molecular cloning , sequencing , characterization , and chromosomal assignment . Regulation TNF TCF19 12161100 971861 Expression of [TNF-alpha] and IL-6 was *regulated* by a , nuclear factor (NF)-kappaB . Regulation TNF TCF19 16489119 1581779 Given the fact that the nuclear factor of activated T cells ( NFAT ) *plays* an important role in the regulation of [TNF-alpha] and can also be activated by ROS , in this study we investigated the potential role of ROS in silica induced NFAT activity as well as TNF-alpha expression in Cl41 cells . Regulation TNF TCF19 18446789 1915763 This *plays* a key role in the expression of cytokines , [tumor necrosis factor alpha (TNF-alpha)] , interleukin 6 , interleukin 8 , tumor growth factor beta , and Fas ligand . Regulation TNF TCF19 18554501 1929378 Lipopolysaccharide induced TNF-alpha factor ( LITAF ) , a , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Regulation TNF TCF19 18692180 1979601 Using chemical inhibitors we show that ( i ) both ERK1/2 MAP kinase and NF-kappaB *play* an important role in IL-10 and [TNF-alpha] production , in macrophages stimulated by Tat . Regulation TNF TCF19 8046241 267008 This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity , but does not modulate activation of NF-kappa B *controlling* the expression of various [TNF-alpha-inducible] genes . Regulation TNF TCF19 8773576 379581 Finally , potential targets of *regulation* by the zinc-finger encoded by egr-1 include the interleukin-2 , CD44 , ICAM-1 , and [tumor necrosis factor] genes . Regulation TNF TCF19 9852224 554676 Altered binding of the NF-GMa is *involved* in the upregulated production of [TNF-alpha] by macrophages of mammary tumor bearing mice . Regulation TNF TCF20 10200294 605489 A novel lipopolysaccharide induced *regulating* [tumor necrosis factor] alpha gene expression : molecular cloning , sequencing , characterization , and chromosomal assignment . Regulation TNF TCF20 12161100 971862 Expression of [TNF-alpha] and IL-6 was *regulated* by a , nuclear factor (NF)-kappaB . Regulation TNF TCF20 16489119 1581780 Given the fact that the nuclear factor of activated T cells ( NFAT ) *plays* an important role in the regulation of [TNF-alpha] and can also be activated by ROS , in this study we investigated the potential role of ROS in silica induced NFAT activity as well as TNF-alpha expression in Cl41 cells . Regulation TNF TCF20 18446789 1915764 This *plays* a key role in the expression of cytokines , [tumor necrosis factor alpha (TNF-alpha)] , interleukin 6 , interleukin 8 , tumor growth factor beta , and Fas ligand . Regulation TNF TCF20 18554501 1929379 Lipopolysaccharide induced TNF-alpha factor ( LITAF ) , a , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Regulation TNF TCF20 18692180 1979602 Using chemical inhibitors we show that ( i ) both ERK1/2 MAP kinase and NF-kappaB *play* an important role in IL-10 and [TNF-alpha] production , in macrophages stimulated by Tat . Regulation TNF TCF20 8046241 267009 This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity , but does not modulate activation of NF-kappa B *controlling* the expression of various [TNF-alpha-inducible] genes . Regulation TNF TCF20 8773576 379582 Finally , potential targets of *regulation* by the zinc-finger encoded by egr-1 include the interleukin-2 , CD44 , ICAM-1 , and [tumor necrosis factor] genes . Regulation TNF TCF20 9852224 554677 Altered binding of the NF-GMa is *involved* in the upregulated production of [TNF-alpha] by macrophages of mammary tumor bearing mice . Regulation TNF TCF21 10200294 605490 A novel lipopolysaccharide induced *regulating* [tumor necrosis factor] alpha gene expression : molecular cloning , sequencing , characterization , and chromosomal assignment . Regulation TNF TCF21 12161100 971863 Expression of [TNF-alpha] and IL-6 was *regulated* by a , nuclear factor (NF)-kappaB . Regulation TNF TCF21 16489119 1581781 Given the fact that the nuclear factor of activated T cells ( NFAT ) *plays* an important role in the regulation of [TNF-alpha] and can also be activated by ROS , in this study we investigated the potential role of ROS in silica induced NFAT activity as well as TNF-alpha expression in Cl41 cells . Regulation TNF TCF21 18446789 1915765 This *plays* a key role in the expression of cytokines , [tumor necrosis factor alpha (TNF-alpha)] , interleukin 6 , interleukin 8 , tumor growth factor beta , and Fas ligand . Regulation TNF TCF21 18554501 1929380 Lipopolysaccharide induced TNF-alpha factor ( LITAF ) , a , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Regulation TNF TCF21 18692180 1979603 Using chemical inhibitors we show that ( i ) both ERK1/2 MAP kinase and NF-kappaB *play* an important role in IL-10 and [TNF-alpha] production , in macrophages stimulated by Tat . Regulation TNF TCF21 8046241 267010 This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity , but does not modulate activation of NF-kappa B *controlling* the expression of various [TNF-alpha-inducible] genes . Regulation TNF TCF21 8773576 379583 Finally , potential targets of *regulation* by the zinc-finger encoded by egr-1 include the interleukin-2 , CD44 , ICAM-1 , and [tumor necrosis factor] genes . Regulation TNF TCF21 9852224 554678 Altered binding of the NF-GMa is *involved* in the upregulated production of [TNF-alpha] by macrophages of mammary tumor bearing mice . Regulation TNF TCF23 10200294 605494 A novel lipopolysaccharide induced *regulating* [tumor necrosis factor] alpha gene expression : molecular cloning , sequencing , characterization , and chromosomal assignment . Regulation TNF TCF23 12161100 971867 Expression of [TNF-alpha] and IL-6 was *regulated* by a , nuclear factor (NF)-kappaB . Regulation TNF TCF23 16489119 1581785 Given the fact that the nuclear factor of activated T cells ( NFAT ) *plays* an important role in the regulation of [TNF-alpha] and can also be activated by ROS , in this study we investigated the potential role of ROS in silica induced NFAT activity as well as TNF-alpha expression in Cl41 cells . Regulation TNF TCF23 18446789 1915769 This *plays* a key role in the expression of cytokines , [tumor necrosis factor alpha (TNF-alpha)] , interleukin 6 , interleukin 8 , tumor growth factor beta , and Fas ligand . Regulation TNF TCF23 18554501 1929385 Lipopolysaccharide induced TNF-alpha factor ( LITAF ) , a , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Regulation TNF TCF23 18692180 1979607 Using chemical inhibitors we show that ( i ) both ERK1/2 MAP kinase and NF-kappaB *play* an important role in IL-10 and [TNF-alpha] production , in macrophages stimulated by Tat . Regulation TNF TCF23 8046241 267014 This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity , but does not modulate activation of NF-kappa B *controlling* the expression of various [TNF-alpha-inducible] genes . Regulation TNF TCF23 8773576 379587 Finally , potential targets of *regulation* by the zinc-finger encoded by egr-1 include the interleukin-2 , CD44 , ICAM-1 , and [tumor necrosis factor] genes . Regulation TNF TCF23 9852224 554682 Altered binding of the NF-GMa is *involved* in the upregulated production of [TNF-alpha] by macrophages of mammary tumor bearing mice . Regulation TNF TCF24 10200294 605496 A novel lipopolysaccharide induced *regulating* [tumor necrosis factor] alpha gene expression : molecular cloning , sequencing , characterization , and chromosomal assignment . Regulation TNF TCF24 12161100 971869 Expression of [TNF-alpha] and IL-6 was *regulated* by a , nuclear factor (NF)-kappaB . Regulation TNF TCF24 16489119 1581787 Given the fact that the nuclear factor of activated T cells ( NFAT ) *plays* an important role in the regulation of [TNF-alpha] and can also be activated by ROS , in this study we investigated the potential role of ROS in silica induced NFAT activity as well as TNF-alpha expression in Cl41 cells . Regulation TNF TCF24 18446789 1915771 This *plays* a key role in the expression of cytokines , [tumor necrosis factor alpha (TNF-alpha)] , interleukin 6 , interleukin 8 , tumor growth factor beta , and Fas ligand . Regulation TNF TCF24 18554501 1929387 Lipopolysaccharide induced TNF-alpha factor ( LITAF ) , a , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Regulation TNF TCF24 18692180 1979609 Using chemical inhibitors we show that ( i ) both ERK1/2 MAP kinase and NF-kappaB *play* an important role in IL-10 and [TNF-alpha] production , in macrophages stimulated by Tat . Regulation TNF TCF24 8046241 267016 This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity , but does not modulate activation of NF-kappa B *controlling* the expression of various [TNF-alpha-inducible] genes . Regulation TNF TCF24 8773576 379589 Finally , potential targets of *regulation* by the zinc-finger encoded by egr-1 include the interleukin-2 , CD44 , ICAM-1 , and [tumor necrosis factor] genes . Regulation TNF TCF24 9852224 554684 Altered binding of the NF-GMa is *involved* in the upregulated production of [TNF-alpha] by macrophages of mammary tumor bearing mice . Regulation TNF TCF25 10200294 605495 A novel lipopolysaccharide induced *regulating* [tumor necrosis factor] alpha gene expression : molecular cloning , sequencing , characterization , and chromosomal assignment . Regulation TNF TCF25 12161100 971868 Expression of [TNF-alpha] and IL-6 was *regulated* by a , nuclear factor (NF)-kappaB . Regulation TNF TCF25 16489119 1581786 Given the fact that the nuclear factor of activated T cells ( NFAT ) *plays* an important role in the regulation of [TNF-alpha] and can also be activated by ROS , in this study we investigated the potential role of ROS in silica induced NFAT activity as well as TNF-alpha expression in Cl41 cells . Regulation TNF TCF25 18446789 1915770 This *plays* a key role in the expression of cytokines , [tumor necrosis factor alpha (TNF-alpha)] , interleukin 6 , interleukin 8 , tumor growth factor beta , and Fas ligand . Regulation TNF TCF25 18554501 1929386 Lipopolysaccharide induced TNF-alpha factor ( LITAF ) , a , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Regulation TNF TCF25 18692180 1979608 Using chemical inhibitors we show that ( i ) both ERK1/2 MAP kinase and NF-kappaB *play* an important role in IL-10 and [TNF-alpha] production , in macrophages stimulated by Tat . Regulation TNF TCF25 8046241 267015 This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity , but does not modulate activation of NF-kappa B *controlling* the expression of various [TNF-alpha-inducible] genes . Regulation TNF TCF25 8773576 379588 Finally , potential targets of *regulation* by the zinc-finger encoded by egr-1 include the interleukin-2 , CD44 , ICAM-1 , and [tumor necrosis factor] genes . Regulation TNF TCF25 9852224 554683 Altered binding of the NF-GMa is *involved* in the upregulated production of [TNF-alpha] by macrophages of mammary tumor bearing mice . Regulation TNF TCF3 10200294 605491 A novel lipopolysaccharide induced *regulating* [tumor necrosis factor] alpha gene expression : molecular cloning , sequencing , characterization , and chromosomal assignment . Regulation TNF TCF3 12161100 971864 Expression of [TNF-alpha] and IL-6 was *regulated* by a , nuclear factor (NF)-kappaB . Regulation TNF TCF3 16489119 1581782 Given the fact that the nuclear factor of activated T cells ( NFAT ) *plays* an important role in the regulation of [TNF-alpha] and can also be activated by ROS , in this study we investigated the potential role of ROS in silica induced NFAT activity as well as TNF-alpha expression in Cl41 cells . Regulation TNF TCF3 18446789 1915766 This *plays* a key role in the expression of cytokines , [tumor necrosis factor alpha (TNF-alpha)] , interleukin 6 , interleukin 8 , tumor growth factor beta , and Fas ligand . Regulation TNF TCF3 18554501 1929381 Lipopolysaccharide induced TNF-alpha factor ( LITAF ) , a , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Regulation TNF TCF3 18692180 1979604 Using chemical inhibitors we show that ( i ) both ERK1/2 MAP kinase and NF-kappaB *play* an important role in IL-10 and [TNF-alpha] production , in macrophages stimulated by Tat . Regulation TNF TCF3 8046241 267011 This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity , but does not modulate activation of NF-kappa B *controlling* the expression of various [TNF-alpha-inducible] genes . Regulation TNF TCF3 8773576 379584 Finally , potential targets of *regulation* by the zinc-finger encoded by egr-1 include the interleukin-2 , CD44 , ICAM-1 , and [tumor necrosis factor] genes . Regulation TNF TCF3 9852224 554679 Altered binding of the NF-GMa is *involved* in the upregulated production of [TNF-alpha] by macrophages of mammary tumor bearing mice . Regulation TNF TCF4 10200294 605492 A novel lipopolysaccharide induced *regulating* [tumor necrosis factor] alpha gene expression : molecular cloning , sequencing , characterization , and chromosomal assignment . Regulation TNF TCF4 12161100 971865 Expression of [TNF-alpha] and IL-6 was *regulated* by a , nuclear factor (NF)-kappaB . Regulation TNF TCF4 16489119 1581783 Given the fact that the nuclear factor of activated T cells ( NFAT ) *plays* an important role in the regulation of [TNF-alpha] and can also be activated by ROS , in this study we investigated the potential role of ROS in silica induced NFAT activity as well as TNF-alpha expression in Cl41 cells . Regulation TNF TCF4 18446789 1915767 This *plays* a key role in the expression of cytokines , [tumor necrosis factor alpha (TNF-alpha)] , interleukin 6 , interleukin 8 , tumor growth factor beta , and Fas ligand . Regulation TNF TCF4 18554501 1929382 Lipopolysaccharide induced TNF-alpha factor ( LITAF ) , a , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Regulation TNF TCF4 18692180 1979605 Using chemical inhibitors we show that ( i ) both ERK1/2 MAP kinase and NF-kappaB *play* an important role in IL-10 and [TNF-alpha] production , in macrophages stimulated by Tat . Regulation TNF TCF4 8046241 267012 This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity , but does not modulate activation of NF-kappa B *controlling* the expression of various [TNF-alpha-inducible] genes . Regulation TNF TCF4 8773576 379585 Finally , potential targets of *regulation* by the zinc-finger encoded by egr-1 include the interleukin-2 , CD44 , ICAM-1 , and [tumor necrosis factor] genes . Regulation TNF TCF4 9852224 554680 Altered binding of the NF-GMa is *involved* in the upregulated production of [TNF-alpha] by macrophages of mammary tumor bearing mice . Regulation TNF TCF7 10200294 605493 A novel lipopolysaccharide induced *regulating* [tumor necrosis factor] alpha gene expression : molecular cloning , sequencing , characterization , and chromosomal assignment . Regulation TNF TCF7 12161100 971866 Expression of [TNF-alpha] and IL-6 was *regulated* by a , nuclear factor (NF)-kappaB . Regulation TNF TCF7 16489119 1581784 Given the fact that the nuclear factor of activated T cells ( NFAT ) *plays* an important role in the regulation of [TNF-alpha] and can also be activated by ROS , in this study we investigated the potential role of ROS in silica induced NFAT activity as well as TNF-alpha expression in Cl41 cells . Regulation TNF TCF7 18446789 1915768 This *plays* a key role in the expression of cytokines , [tumor necrosis factor alpha (TNF-alpha)] , interleukin 6 , interleukin 8 , tumor growth factor beta , and Fas ligand . Regulation TNF TCF7 18554501 1929383 Lipopolysaccharide induced TNF-alpha factor ( LITAF ) , a , can *regulate* [tumor necrosis factor alpha (TNF-alpha)] transcription . Regulation TNF TCF7 18692180 1979606 Using chemical inhibitors we show that ( i ) both ERK1/2 MAP kinase and NF-kappaB *play* an important role in IL-10 and [TNF-alpha] production , in macrophages stimulated by Tat . Regulation TNF TCF7 8046241 267013 This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity , but does not modulate activation of NF-kappa B *controlling* the expression of various [TNF-alpha-inducible] genes . Regulation TNF TCF7 8773576 379586 Finally , potential targets of *regulation* by the zinc-finger encoded by egr-1 include the interleukin-2 , CD44 , ICAM-1 , and [tumor necrosis factor] genes . Regulation TNF TCF7 9852224 554681 Altered binding of the NF-GMa is *involved* in the upregulated production of [TNF-alpha] by macrophages of mammary tumor bearing mice . Regulation TNF TCL4 22272221 2545174 The *effect* of and MION-47 on the secretion of interlukin-6 (IL-6) and [tumor necrosis factor-alpha] ( TNF-a ) , the production of nitric oxides and the mitochondrial membrane potentials in murine macrophage cells ( RAW264.7 ) was compared . Regulation TNF TCL6 22272221 2545175 The *effect* of and MION-47 on the secretion of interlukin-6 (IL-6) and [tumor necrosis factor-alpha] ( TNF-a ) , the production of nitric oxides and the mitochondrial membrane potentials in murine macrophage cells ( RAW264.7 ) was compared . Regulation TNF TDGF1P3 9574560 502561 This study was undertaken to evaluate the *role* of CD14 and and 4 ( CR4 ) in mediating [TNF] release and NF-kappaB activation induced by LPS and cell wall preparations from group B streptococci type III ( GBS ) . Regulation TNF TESC 15545830 1337979 Thus , the *effect* of on the production of [TNF-alpha] and IL-10 was also examined . Regulation TNF TFF3 19238529 2044838 The main aims of this study is to evaluate *effects* of intraperitoneal injection recombinant human on the expression of [tumour necrosis factor alpha (TNF-alpha)] , toll-like receptor 4 ( TLR4 ) , and nuclear factor kappaB (NF-kappaB) in trinitrobenzene sulphonic acid ( TNBS ) induced colitis mice . Regulation TNF TFPI 15217748 1263782 In this study we investigated the *effects* of and Nor on IL-6 , IL-8 and [TNF-alpha] expression in human monocytes stimulated with lipopolysaccharide (LPS) in whole blood , analyzed intracellularly by flow cytometry . Regulation TNF TFPI 15217748 1263786 All cytokines peaked from 3 h to 6 h . and Nor had comparable *effects* on the expression of IL-6 , IL-8 and [TNF-a] in monocytes . Regulation TNF TFPI 9021920 413142 had no *effect* on [TNF] receptor expression . Regulation TNF TFPT 15499968 1326832 The aim of current study was to investigate the *effect* of PKCalpha activation by on NF-kappaB activation and subsequently on [TNFalpha] gene expression and caspase 3 induction in LLC-PK1 cells . Regulation TNF TGFB1 11747628 889307 As desmoid fibroblasts did not produce tumor necrosis factor-alpha (TNF-alpha) but were sensitive to it , which enhanced glycosaminoglycans ( GAG ) accumulation , we assessed the *effects* on [TNF-alpha] production by human monocytes . Regulation TNF TGFB1 12524413 1047914 MMP2 secretion by PSCs was significantly increased by and IL-6 , but was not *affected* by [TNF-alpha] . Regulation TNF TGFB1 15361231 1293650 IFN-gamma and [TNF-alpha] play a role in both protective immunity and the pathology of the infection , and the inflammatory disease may be *regulated* by IL-10 and . Regulation TNF TGFB1 15553672 1338690 Two out of 6 pts who experienced stable disease after the treatment had high IFN-gamma and [TNF-alpha] responses and no or IL-4 *response* . Regulation TNF TGFB1 16249231 1553521 The immunohistological findings of a limited sample suggest a *role* for BM in sacroiliitis , for [TNFalpha] and IL6 in early , active lesions , and for at the time of secondary cartilage and bone proliferation . Regulation TNF TGFB1 18475695 407245 *Role* of in down regulating [TNF] production by alveolar macrophages during asbestos induced pulmonary fibrosis . Regulation TNF TGFB1 20014292 2241050 activated kinase 1 signaling pathways *regulate* [TNF-alpha] production by titanium alloy particles in RAW 264.7 cells . Regulation TNF TGFB1 7948746 277297 In this study we have analysed in parallel the *effects* of on both DNA synthesis and production of the cytokines IL-1 , IL-2 , IL-6 , and [TNF-alpha] by pokeweed mitogen stimulated peripheral blood mononuclear cells . Regulation TNF TGFB1 9369823 464070 This study suggests that interleukin-10 and can *regulate* [tumor necrosis factor-alpha] release from amniochorion under different conditions and by a different mechanism . Regulation TNF TGFB2 15361231 1293651 IFN-gamma and [TNF-alpha] play a role in both protective immunity and the pathology of the infection , and the inflammatory disease may be *regulated* by IL-10 and . Regulation TNF TGFB2 20014292 2241051 activated kinase 1 signaling pathways *regulate* [TNF-alpha] production by titanium alloy particles in RAW 264.7 cells . Regulation TNF TGFB2 2121884 143909 Role of interferon-gamma in counteracting the suppressive *effects* of and glucocorticoids on the production of [tumor necrosis factor-alpha] . Regulation TNF TGFB2 9369823 464071 This study suggests that interleukin-10 and can *regulate* [tumor necrosis factor-alpha] release from amniochorion under different conditions and by a different mechanism . Regulation TNF TGFB3 15361231 1293652 IFN-gamma and [TNF-alpha] play a role in both protective immunity and the pathology of the infection , and the inflammatory disease may be *regulated* by IL-10 and . Regulation TNF TGFB3 20014292 2241052 activated kinase 1 signaling pathways *regulate* [TNF-alpha] production by titanium alloy particles in RAW 264.7 cells . Regulation TNF TGFB3 9369823 464072 This study suggests that interleukin-10 and can *regulate* [tumor necrosis factor-alpha] release from amniochorion under different conditions and by a different mechanism . Regulation TNF THRA 16945012 1609914 Compound 1 did not affect the [tumor necrosis factor-alpha-] or lipopolysaccharide induced *response* , suggesting selective inhibition of the RANKL induced pathway . Regulation TNF THRAP3 16945012 1609918 Compound 1 did not affect the [tumor necrosis factor-alpha-] or lipopolysaccharide induced *response* , suggesting selective inhibition of the RANKL induced pathway . Regulation TNF TIA1 18438838 1915446 T cell intracytoplasmic antigen 1 ( TIA-1 ) and are *involved* in posttranscriptional regulation of the expression of [tumor necrosis factor alpha (TNFalpha)] and other proteins . Regulation TNF TIFA 11798190 902340 Our results suggest that is *involved* in the [TNF] mediated signaling by its interaction with TRAF2 . Regulation TNF TIMP1 21199330 2493927 The mRNA levels of tumour necrosis factor (TNF)-a and protein levels of p38 , cytosolic phospolipase A2 and cyclooxygenase 2 were significantly increased in the D DSS ( + ) pups and were accompanied by a decrease in the protein level of tissue inhibitor of metalloproteinases ( ) 3 , a negative *regulator* of [TNF-a] . Regulation TNF TIMP1 2167246 140133 Furthermore , the fact that [TNF] and IL-1 differently *controlled* the production of suggests that the signal pathway of TNF for TIMP production is different from that of IL-1 . Regulation TNF TIMP3 19082505 2018332 [TNF-alpha] production and the bioavailability of its receptors on the cell surface are *regulated* by TACE ( TNF-alpha converting enzyme ) , a pleiotropic metalloprotease also known as ADAM17 , and its specific inhibitor . Regulation TNF TLR1 15994412 1447018 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for [tumor necrosis factor] ( TNF-alpha ) , interleukin 6 , nitric oxide synthase-II ( iNOS ) , and NADPH oxidase 2 (Nox2) . Regulation TNF TLR1 16849509 1588491 We have previously reported that despite normal basal expression of TLRs and associated signaling intermediates , human neonatal cord blood monocytes demonstrate severe impairment in [TNF-alpha] production in *response* to triacylated ( ) and diacylated ( TLR 2/6 ) bacterial lipopeptides ( BLPs ) . Regulation TNF TLR1 17664270 1793901 JNK controls [tumor necrosis factor] alpha production and mediated macrophage *responses* to Borrelia burgdorferi , the causative agent of Lyme disease , and the TLR1/TLR2-specific agonist PAM ( 3 ) CSK ( 4 ) . Regulation TNF TLR1 19322177 2064491 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ) , but not [TNF] , in *response* to ligands . Regulation TNF TLR1 19890037 2165894 MAPKs are crucial for [TNF-alpha] and IL-6 production by innate immune cells in *response* to ligands . Regulation TNF TLR1 20059544 2248066 Results obtained using V. vulnificus type strain ATCC 27562 showed that ( 1 ) TLR4 signaling is myeloid differentiation factor 88 dependent and plays a key role in TNFalpha production by mouse blood and splenocytes stimulated ex vivo with inactivated V. vulnificus cells , ( 2 ) TLR4 signaling is deleterious in a mouse model of V. vulnificus infection , ( 3 ) signaling by TLR ( s ) , exclusive of TLR4 , is needed to eradicate infection , and ( 4 ) the mediated [TNFalpha] *response* plays a critical role in determining the outcome of infection . Regulation TNF TLR1 21968712 2617052 In this report , we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages , leading to incapability for the production of inflammatory cytokines like [tumor necrosis factor (TNF)-a] and interleukin (IL)-1ß in *response* to stimulation . Regulation TNF TLR1 23504259 2809803 Adenosine signaling suppresses the *dependent* expression of [TNF-a] , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Regulation TNF TLR1 24771857 2937082 At the cellular level , Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower [TNF-a] and higher IL-10 in *response* to ligands than did their WT counterparts . Regulation TNF TLR10 15994412 1447026 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for [tumor necrosis factor] ( TNF-alpha ) , interleukin 6 , nitric oxide synthase-II ( iNOS ) , and NADPH oxidase 2 (Nox2) . Regulation TNF TLR10 17664270 1793909 JNK controls [tumor necrosis factor] alpha production and mediated macrophage *responses* to Borrelia burgdorferi , the causative agent of Lyme disease , and the TLR1/TLR2-specific agonist PAM ( 3 ) CSK ( 4 ) . Regulation TNF TLR10 19322177 2064499 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ) , but not [TNF] , in *response* to ligands . Regulation TNF TLR10 19890037 2165902 MAPKs are crucial for [TNF-alpha] and IL-6 production by innate immune cells in *response* to ligands . Regulation TNF TLR10 20059544 2248074 Results obtained using V. vulnificus type strain ATCC 27562 showed that ( 1 ) TLR4 signaling is myeloid differentiation factor 88 dependent and plays a key role in TNFalpha production by mouse blood and splenocytes stimulated ex vivo with inactivated V. vulnificus cells , ( 2 ) TLR4 signaling is deleterious in a mouse model of V. vulnificus infection , ( 3 ) signaling by TLR ( s ) , exclusive of TLR4 , is needed to eradicate infection , and ( 4 ) the mediated [TNFalpha] *response* plays a critical role in determining the outcome of infection . Regulation TNF TLR10 21968712 2617060 In this report , we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages , leading to incapability for the production of inflammatory cytokines like [tumor necrosis factor (TNF)-a] and interleukin (IL)-1ß in *response* to stimulation . Regulation TNF TLR10 23504259 2809811 Adenosine signaling suppresses the *dependent* expression of [TNF-a] , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Regulation TNF TLR10 24771857 2937090 At the cellular level , Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower [TNF-a] and higher IL-10 in *response* to ligands than did their WT counterparts . Regulation TNF TLR2 11937558 928176 Lip19 or Lip12 activated [TNF-alpha] production from RAW264.7 and THP-1 cells in a *dependent* manner . Regulation TNF TLR2 12874236 1114979 Taken together , our data demonstrate that MyD88 dependent pathways are crucial for activation by HKBA and that *plays* a role in [TNF] , but not IL-12p40 pathways activated by this microbial product . Regulation TNF TLR2 12875990 1115266 C57BL/10ScN ( TLR4 deletion mutant ) macrophages produce [TNFalpha] in *response* to , 3 , 7 , and 9 agonists , but not the TLR4 agonist E. coli LPS . Regulation TNF TLR2 15096475 1244258 In *response* to , -4 and -5 engagement , approximately 50 % of monocytes produced [TNF-alpha] , compared to only 5 % after induction with IFN-gamma or GM-CSF . Regulation TNF TLR2 15522205 1329206 These signals are required for optimal production of [TNFalpha] in *response* to stimulation , and are absent in macrophages from TLR4 mutant animals . Regulation TNF TLR2 15955814 1434498 SaeLM induced a *dependent* production of [tumor necrosis factor-alpha (TNF-alpha)] by human THP-1 monocyte/macrophage cell lines and interestingly was found to be the strongest inducer of this pro-inflammatory cytokine when compared with other LAM/LM-like molecules . Regulation TNF TLR2 15994412 1447019 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for [tumor necrosis factor] ( TNF-alpha ) , interleukin 6 , nitric oxide synthase-II ( iNOS ) , and NADPH oxidase 2 (Nox2) . Regulation TNF TLR2 16129673 1482309 The CD11b/CD18 binding activity played a contributory role to *dependent* induction of [tumor necrosis factor-alpha] by fimbriae but was involved in specific down-regulation of interleukin-12 . Regulation TNF TLR2 16480927 1548549 The marked increase of [TNFalpha] *response* to ligands correlated with a higher TLR2 expression in a group of IBD patients , suggesting that an abnormal mechanism may provide an excess of inflammatory mediators during the active phase of IBDs . Regulation TNF TLR2 16849509 1588492 We have previously reported that despite normal basal expression of TLRs and associated signaling intermediates , human neonatal cord blood monocytes demonstrate severe impairment in [TNF-alpha] production in *response* to triacylated ( TLR 2/1 ) and diacylated ( ) bacterial lipopeptides ( BLPs ) . Regulation TNF TLR2 16879256 1593959 Cultured TECs grown from healthy mice produced the cytokines [TNF-alpha] and KC in *response* to stimulation by LPS and synthetic and TLR4 agonists . Regulation TNF TLR2 17617634 1786996 However , we found that di-acylated LM inhibition of LPS induced [tumor necrosis factor] secretion by murine macrophages was *independent* of , mannose receptor , or the murine ortholog SIGNR1 . Regulation TNF TLR2 17637846 1770798 [TNF-alpha-induction] was TLR4- and *dependent* for live but not for killed B. abortus . Regulation TNF TLR2 17664270 1793902 JNK controls [tumor necrosis factor] alpha production and mediated macrophage *responses* to Borrelia burgdorferi , the causative agent of Lyme disease , and the TLR1/TLR2-specific agonist PAM ( 3 ) CSK ( 4 ) . Regulation TNF TLR2 18256754 1839713 The production of [TNF-alpha] and IFN-alpha cytokines by peripheral blood mononuclears in *response* to stimulation by , TLR4 , TLR5 , TLR9 ligands ( zymosan , LPS , flagellin , and CpG-oligodeoxynucleotide , respectively ) was studied in donors and patients with common variable immunodeficiency . Regulation TNF TLR2 19274437 2182423 The present study defines the expression of , and the modulatory *role* of Glycogen synthase kinase (GSK)-3beta inhibitor on [TLR2/Nuclear Factor-kappa B (NF-kappaB)] signaling following myocardial ischemia-reperfusion ( MI-R ) injury in rats . Regulation TNF TLR2 19322177 2064492 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ) , but not [TNF] , in *response* to ligands . Regulation TNF TLR2 19890037 2165895 MAPKs are crucial for [TNF-alpha] and IL-6 production by innate immune cells in *response* to ligands . Regulation TNF TLR2 19915052 2166526 The inhibitory *effect* of on the release of [TNF-alpha] but not of IL-12p70 was mediated by PI3K . Regulation TNF TLR2 20059544 2248067 Results obtained using V. vulnificus type strain ATCC 27562 showed that ( 1 ) TLR4 signaling is myeloid differentiation factor 88 dependent and plays a key role in TNFalpha production by mouse blood and splenocytes stimulated ex vivo with inactivated V. vulnificus cells , ( 2 ) TLR4 signaling is deleterious in a mouse model of V. vulnificus infection , ( 3 ) signaling by TLR ( s ) , exclusive of TLR4 , is needed to eradicate infection , and ( 4 ) the mediated [TNFalpha] *response* plays a critical role in determining the outcome of infection . Regulation TNF TLR2 21182083 2373741 Analysis of upstream signaling events revealed that mediated MyD88 *dependent* participation of IL-1R activated kinase (IRAK)1 , [TNF receptor associated factor (TRAF)6] and TGFß activated kinase (TAK)1 is essential to induce cystatin mediated I?B kinase ( IKK ) /NF-?B activation in macrophages . Regulation TNF TLR2 21968712 2617053 In this report , we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages , leading to incapability for the production of inflammatory cytokines like [tumor necrosis factor (TNF)-a] and interleukin (IL)-1ß in *response* to stimulation . Regulation TNF TLR2 22103323 2529653 The dependent [TNF-a] *response* of macrophages to heat killed lgt mutant bacteria was reduced . Regulation TNF TLR2 22956655 2688285 Anti-inflammatory SMAMPs prevented the induction of [tumor necrosis factor (TNF)] , interleukin 6 (IL-6) , and IL-10 in *response* to S. aureus or LTA , but no other ligands . Regulation TNF TLR2 23404403 2743609 In vitro stimulation of bone marrow derived macrophages with the ?kdhAB mutant induced higher levels of [TNF-a] and IL-1ß in a *dependent* manner . Regulation TNF TLR2 23504259 2809804 Adenosine signaling suppresses the *dependent* expression of [TNF-a] , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Regulation TNF TLR2 24771857 2937083 At the cellular level , Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower [TNF-a] and higher IL-10 in *response* to ligands than did their WT counterparts . Regulation TNF TLR3 15994412 1447020 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for [tumor necrosis factor] ( TNF-alpha ) , interleukin 6 , nitric oxide synthase-II ( iNOS ) , and NADPH oxidase 2 (Nox2) . Regulation TNF TLR3 17664270 1793903 JNK controls [tumor necrosis factor] alpha production and mediated macrophage *responses* to Borrelia burgdorferi , the causative agent of Lyme disease , and the TLR1/TLR2-specific agonist PAM ( 3 ) CSK ( 4 ) . Regulation TNF TLR3 19322177 2064493 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ) , but not [TNF] , in *response* to ligands . Regulation TNF TLR3 19890037 2165896 MAPKs are crucial for [TNF-alpha] and IL-6 production by innate immune cells in *response* to ligands . Regulation TNF TLR3 20059544 2248068 Results obtained using V. vulnificus type strain ATCC 27562 showed that ( 1 ) TLR4 signaling is myeloid differentiation factor 88 dependent and plays a key role in TNFalpha production by mouse blood and splenocytes stimulated ex vivo with inactivated V. vulnificus cells , ( 2 ) TLR4 signaling is deleterious in a mouse model of V. vulnificus infection , ( 3 ) signaling by TLR ( s ) , exclusive of TLR4 , is needed to eradicate infection , and ( 4 ) the mediated [TNFalpha] *response* plays a critical role in determining the outcome of infection . Regulation TNF TLR3 20375303 2261818 Importantly , stimulation of Mk2 ( -/- ) cells through or TLR4 severely impaired TNF-alpha protein production but did not *affect* [TNF-alpha] mRNA induction . Regulation TNF TLR3 21454254 2448142 dependent *regulation* of cytokines in human mesangial cells : a novel role for IP-10 and [TNF-alpha] in hepatitis C-associated glomerulonephritis . Regulation TNF TLR3 21968712 2617054 In this report , we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages , leading to incapability for the production of inflammatory cytokines like [tumor necrosis factor (TNF)-a] and interleukin (IL)-1ß in *response* to stimulation . Regulation TNF TLR3 22693231 2638679 Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß) , interleukin 6 (IL-6) , interleukin 10 (IL-10) , interleukin 12 (IL-12) , and [tumor necrosis factor a (TNF-a)] *responses* to and TLR4 stimulation . Regulation TNF TLR3 23504259 2809805 Adenosine signaling suppresses the *dependent* expression of [TNF-a] , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Regulation TNF TLR3 24138989 2882714 Furthermore , from the optimized IRN , we confirmed 45 interactions between proteins in biological experiments and identified 37 new regulatory interactions and 8 false positive interactions , including the following interactions : IL1ß regulates TLR3 , *regulates* IFN-ß and [TNF] regulates IL6 . Regulation TNF TLR3 24771857 2937084 At the cellular level , Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower [TNF-a] and higher IL-10 in *response* to ligands than did their WT counterparts . Regulation TNF TLR4 11992285 938691 Production of [tumor necrosis factor (TNF)] and interleukin (IL)-1alpha and IL-1beta by mouse macrophages in response to C. albicans stimulation was not *affected* by , and the candidacidal capacities of the neutrophils and macrophages of C3H/HeJ mice were normal . Regulation TNF TLR4 15994412 1447021 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for [tumor necrosis factor] ( TNF-alpha ) , interleukin 6 , nitric oxide synthase-II ( iNOS ) , and NADPH oxidase 2 (Nox2) . Regulation TNF TLR4 16109884 1474087 HIV impairs [TNF-alpha] release in *response* to stimulation in human macrophages in vitro . Regulation TNF TLR4 17034424 1683146 In this study we have shown that , whilst NF-kappaB activation and production of [TNF-alpha] and interleukin-12 by murine RAW264.7 and J774.2 cells in *response* to stimulation by , -5 , -7 or -9 , was reduced by prior stimulation with TLR4 , -5 , -7 or -9 ligands , the primary stimulation of TLR3 , which does not use the MyD88 pathway , did not reduce the TNF-alpha or interleukin-12 responses to subsequent TLR stimulation . Regulation TNF TLR4 17395780 1766171 Here we demonstrate that Rab7b can negatively *regulate* lipopolysaccharide (LPS) induced production of [tumor necrosis factor (TNF)-alpha] , IL-6 , nitric oxide , and IFN-beta , and potentiate LPS induced activation of mitogen activated protein kinase , nuclear factor kappaB , and IFN regulatory factor 3 signaling pathways in macrophages by promoting the degradation of . Regulation TNF TLR4 17445776 1737162 CCL-34 activated NF-kappaB in a *dependent* manner and stimulated [TNF-alpha] production in bone marrow cells of TLR4-functional C3H/HeN mice but not in those of TLR4-defective C3H/HeJ mice . Regulation TNF TLR4 17496895 1744444 Our results indicate that two different complexes sequentially form and selectively *control* early and late [TNF] production . Regulation TNF TLR4 17592223 1768216 Prolonged alcohol exposure also resulted in an increase in NF-kappaB and [TNFalpha] production in *response* to stimulation with LPS . Regulation TNF TLR4 17664270 1793904 JNK controls [tumor necrosis factor] alpha production and mediated macrophage *responses* to Borrelia burgdorferi , the causative agent of Lyme disease , and the TLR1/TLR2-specific agonist PAM ( 3 ) CSK ( 4 ) . Regulation TNF TLR4 18028374 1866901 While in cells isolated from patients with Crohn 's disease with the wild-type NOD2 allele , the NOD2 engagement led to a similar cross-tolerance to *dependent* stimulation of [TNF-alpha] , the cross-tolerance between NOD2 and TLR4 was absent in the cells of five patients homozygous for the 3020insC NOD2 mutation , leading to uninhibited release of TNF-alpha by TLR4 ligands and intestinal bacteria . Regulation TNF TLR4 18256754 1839717 Reduced stimulated production of [TNF-alpha] in *response* to stimulation with and TLR5 ligands in vitro was detected in patients with common variable immunodeficiency . Regulation TNF TLR4 18442564 1900515 This study examined whether *regulates* [TNF-alpha] and interleukin (IL)-1beta peptide production during global ischemia/reperfusion and whether TLR4 signaling influences postischemic cardiac function through TNF-alpha and IL-1beta . Regulation TNF TLR4 19028791 2022900 FXR activation by natural and synthetic ligands in these cell types attenuated IL-1beta , IL-6 , and [TNF-alpha] gene induction in *response* to activation by LPS . Regulation TNF TLR4 19133650 2053774 In contrast , the absence of had no *effect* on the early , ethanol induced increase in either C3b or [TNF-alpha] . Regulation TNF TLR4 19322177 2064494 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ) , but not [TNF] , in *response* to ligands . Regulation TNF TLR4 19513622 2092658 Our results suggest that *plays* an important role in the immunological mechanism of apoptosis and secretion of [TNF-alpha] of human term trophoblast cells stimulated by LPS . Regulation TNF TLR4 19753301 2135338 Recovery of shRNA sequences from surviving cells led to the identification of unique shRNA sequences that significantly inhibited *dependent* [TNF-alpha] gene expression . Regulation TNF TLR4 19828114 2184126 We conclude that neutrophil recruitment to the milk spaces is : ( i ) mediated through [TNFalpha] , which is produced by alveolar macrophages in *response* to LPS/ signaling and ( ii ) is dependent on IL8 and IL1beta signaling and regulated by iNOS derived NO . Regulation TNF TLR4 19890037 2165897 MAPKs are crucial for [TNF-alpha] and IL-6 production by innate immune cells in *response* to ligands . Regulation TNF TLR4 20018613 2191637 In the current study , we demonstrate that incubation of Prx1 with thioglycollate elicited murine macrophages or immature bone marrow derived dendritic cells resulted in *dependent* secretion of [TNF-alpha] and IL-6 and dendritic cell maturation . Regulation TNF TLR4 20059544 2248069 Results obtained using V. vulnificus type strain ATCC 27562 showed that ( 1 ) TLR4 signaling is myeloid differentiation factor 88 dependent and plays a key role in TNFalpha production by mouse blood and splenocytes stimulated ex vivo with inactivated V. vulnificus cells , ( 2 ) TLR4 signaling is deleterious in a mouse model of V. vulnificus infection , ( 3 ) signaling by TLR ( s ) , exclusive of TLR4 , is needed to eradicate infection , and ( 4 ) the mediated [TNFalpha] *response* plays a critical role in determining the outcome of infection . Regulation TNF TLR4 20337701 2273169 may be *involved* in [TNF-alpha] production from RAW264.7 cells and enhanced host resistance induced by p60 administration . Regulation TNF TLR4 20360853 2231829 Early lung expression of [TNF-alpha] , IL-12 , and chemokines was *dependent* , while IFN-gamma production and the later expression of TNF-alpha and IL-12 was dependent on TLR9 . Regulation TNF TLR4 20375303 2261819 Importantly , stimulation of Mk2 ( -/- ) cells through TLR3 or severely impaired TNF-alpha protein production but did not *affect* [TNF-alpha] mRNA induction . Regulation TNF TLR4 20547845 2284907 A wholly synthetic 20-mer peptide containing cysteine 106 from within the cytokine stimulating B box mediates *dependent* activation of macrophage [TNF] release . Regulation TNF TLR4 20550956 2315747 *Role* for in [TNF-alpha] secretion by murine macrophages in response to polysaccharide Krestin , a Trametes versicolor mushroom extract . Regulation TNF TLR4 21033154 2338864 To characterize the *role* of in silica induced production of [tumor necrosis factor alpha (TNFalpha)] from macrophage cell line . Regulation TNF TLR4 21033154 2338865 To examine the *involvement* of in silica induced [TNFalpha] release , the neutralizing antibody ( HTA125 ) against human TLR4 receptor was employed to pretreat THP-1 cells prior to silica treatment . Regulation TNF TLR4 21182083 2373742 Analysis of upstream signaling events revealed that mediated MyD88 *dependent* participation of IL-1R activated kinase (IRAK)1 , [TNF receptor associated factor (TRAF)6] and TGFß activated kinase (TAK)1 is essential to induce cystatin mediated I?B kinase ( IKK ) /NF-?B activation in macrophages . Regulation TNF TLR4 21603190 2430827 Albumin produced a dose dependent and *dependent* increase in NF-?B activation and [TNF-a] gene expression in vitro . Regulation TNF TLR4 21968712 2617055 In this report , we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages , leading to incapability for the production of inflammatory cytokines like [tumor necrosis factor (TNF)-a] and interleukin (IL)-1ß in *response* to stimulation . Regulation TNF TLR4 22262768 2564509 Heme induces *dependent* production of [tumor necrosis factor (TNF)] , whereas heme cytotoxicity has been attributed to its ability to intercalate into cell membranes and cause oxidative stress . Regulation TNF TLR4 22262768 2564512 Heme induced cell death required TNFR1 and *dependent* [TNF] production . Regulation TNF TLR4 22262768 2564516 Taken together , these results revealed that heme induces macrophage necrosis through 2 synergistic mechanisms : *dependent* expression of [TNF] and TLR4 independent generation of ROS . Regulation TNF TLR4 22693231 2638680 Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß) , interleukin 6 (IL-6) , interleukin 10 (IL-10) , interleukin 12 (IL-12) , and [tumor necrosis factor a (TNF-a)] *responses* to Toll-like receptor (TLR) 3 and stimulation . Regulation TNF TLR4 22761329 2670390 Both drugs , as monotherapy or in combination , induce release of [TNF-a] and nitric oxide in a *dependent* manner . Regulation TNF TLR4 22761329 2670391 In vitro , both the drugs kill macrophage bound L. donovani by inducing release of [TNF-a] and nitric oxide in a *dependent* manner . Regulation TNF TLR4 23504259 2809806 Adenosine signaling suppresses the *dependent* expression of [TNF-a] , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Regulation TNF TLR4 23758142 2807442 The accumulation of CCL2 , CX3CL1 , [tumor necrosis factor-a] , interleukin (IL)-6 , IL-10 , IL-12 , and interferon-? in wound fluids was not *dependent* . Regulation TNF TLR4 24771857 2937085 At the cellular level , Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower [TNF-a] and higher IL-10 in *response* to ligands than did their WT counterparts . Regulation TNF TLR5 15994412 1447022 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for [tumor necrosis factor] ( TNF-alpha ) , interleukin 6 , nitric oxide synthase-II ( iNOS ) , and NADPH oxidase 2 (Nox2) . Regulation TNF TLR5 17664270 1793905 JNK controls [tumor necrosis factor] alpha production and mediated macrophage *responses* to Borrelia burgdorferi , the causative agent of Lyme disease , and the TLR1/TLR2-specific agonist PAM ( 3 ) CSK ( 4 ) . Regulation TNF TLR5 18256754 1839718 Reduced stimulated production of [TNF-alpha] in *response* to stimulation with TLR4 and ligands in vitro was detected in patients with common variable immunodeficiency . Regulation TNF TLR5 19322177 2064495 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ) , but not [TNF] , in *response* to ligands . Regulation TNF TLR5 19890037 2165898 MAPKs are crucial for [TNF-alpha] and IL-6 production by innate immune cells in *response* to ligands . Regulation TNF TLR5 20059544 2248070 Results obtained using V. vulnificus type strain ATCC 27562 showed that ( 1 ) TLR4 signaling is myeloid differentiation factor 88 dependent and plays a key role in TNFalpha production by mouse blood and splenocytes stimulated ex vivo with inactivated V. vulnificus cells , ( 2 ) TLR4 signaling is deleterious in a mouse model of V. vulnificus infection , ( 3 ) signaling by TLR ( s ) , exclusive of TLR4 , is needed to eradicate infection , and ( 4 ) the mediated [TNFalpha] *response* plays a critical role in determining the outcome of infection . Regulation TNF TLR5 21968712 2617056 In this report , we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages , leading to incapability for the production of inflammatory cytokines like [tumor necrosis factor (TNF)-a] and interleukin (IL)-1ß in *response* to stimulation . Regulation TNF TLR5 23504259 2809807 Adenosine signaling suppresses the *dependent* expression of [TNF-a] , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Regulation TNF TLR5 24771857 2937086 At the cellular level , Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower [TNF-a] and higher IL-10 in *response* to ligands than did their WT counterparts . Regulation TNF TLR6 15994412 1447027 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for [tumor necrosis factor] ( TNF-alpha ) , interleukin 6 , nitric oxide synthase-II ( iNOS ) , and NADPH oxidase 2 (Nox2) . Regulation TNF TLR6 16849509 1588493 We have previously reported that despite normal basal expression of TLRs and associated signaling intermediates , human neonatal cord blood monocytes demonstrate severe impairment in [TNF-alpha] production in *response* to triacylated ( TLR 2/1 ) and diacylated ( ) bacterial lipopeptides ( BLPs ) . Regulation TNF TLR6 17664270 1793910 JNK controls [tumor necrosis factor] alpha production and mediated macrophage *responses* to Borrelia burgdorferi , the causative agent of Lyme disease , and the TLR1/TLR2-specific agonist PAM ( 3 ) CSK ( 4 ) . Regulation TNF TLR6 19322177 2064500 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ) , but not [TNF] , in *response* to ligands . Regulation TNF TLR6 19890037 2165903 MAPKs are crucial for [TNF-alpha] and IL-6 production by innate immune cells in *response* to ligands . Regulation TNF TLR6 20059544 2248075 Results obtained using V. vulnificus type strain ATCC 27562 showed that ( 1 ) TLR4 signaling is myeloid differentiation factor 88 dependent and plays a key role in TNFalpha production by mouse blood and splenocytes stimulated ex vivo with inactivated V. vulnificus cells , ( 2 ) TLR4 signaling is deleterious in a mouse model of V. vulnificus infection , ( 3 ) signaling by TLR ( s ) , exclusive of TLR4 , is needed to eradicate infection , and ( 4 ) the mediated [TNFalpha] *response* plays a critical role in determining the outcome of infection . Regulation TNF TLR6 21968712 2617061 In this report , we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages , leading to incapability for the production of inflammatory cytokines like [tumor necrosis factor (TNF)-a] and interleukin (IL)-1ß in *response* to stimulation . Regulation TNF TLR6 23504259 2809812 Adenosine signaling suppresses the *dependent* expression of [TNF-a] , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Regulation TNF TLR6 24771857 2937091 At the cellular level , Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower [TNF-a] and higher IL-10 in *response* to ligands than did their WT counterparts . Regulation TNF TLR7 15994412 1447023 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for [tumor necrosis factor] ( TNF-alpha ) , interleukin 6 , nitric oxide synthase-II ( iNOS ) , and NADPH oxidase 2 (Nox2) . Regulation TNF TLR7 17485113 1744268 Distinct role of MAPKAPK-2 in the *regulation* of [TNF] gene expression by and 9 ligands . Regulation TNF TLR7 17664270 1793906 JNK controls [tumor necrosis factor] alpha production and mediated macrophage *responses* to Borrelia burgdorferi , the causative agent of Lyme disease , and the TLR1/TLR2-specific agonist PAM ( 3 ) CSK ( 4 ) . Regulation TNF TLR7 19251253 2045123 The effect of toll-like receptor (TLR) 7 ligand pretreatment on the production of [tumor necrosis factor (TNF)-alpha] in *response* to or TLR2 ligand was examined in order to establish a new TLR mediated tolerance . Regulation TNF TLR7 19322177 2064496 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ) , but not [TNF] , in *response* to ligands . Regulation TNF TLR7 19890037 2165899 MAPKs are crucial for [TNF-alpha] and IL-6 production by innate immune cells in *response* to ligands . Regulation TNF TLR7 20059544 2248071 Results obtained using V. vulnificus type strain ATCC 27562 showed that ( 1 ) TLR4 signaling is myeloid differentiation factor 88 dependent and plays a key role in TNFalpha production by mouse blood and splenocytes stimulated ex vivo with inactivated V. vulnificus cells , ( 2 ) TLR4 signaling is deleterious in a mouse model of V. vulnificus infection , ( 3 ) signaling by TLR ( s ) , exclusive of TLR4 , is needed to eradicate infection , and ( 4 ) the mediated [TNFalpha] *response* plays a critical role in determining the outcome of infection . Regulation TNF TLR7 21968712 2617057 In this report , we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages , leading to incapability for the production of inflammatory cytokines like [tumor necrosis factor (TNF)-a] and interleukin (IL)-1ß in *response* to stimulation . Regulation TNF TLR7 23504259 2809808 Adenosine signaling suppresses the *dependent* expression of [TNF-a] , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Regulation TNF TLR7 24771857 2937087 At the cellular level , Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower [TNF-a] and higher IL-10 in *response* to ligands than did their WT counterparts . Regulation TNF TLR8 15994412 1447024 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for [tumor necrosis factor] ( TNF-alpha ) , interleukin 6 , nitric oxide synthase-II ( iNOS ) , and NADPH oxidase 2 (Nox2) . Regulation TNF TLR8 17664270 1793907 JNK controls [tumor necrosis factor] alpha production and mediated macrophage *responses* to Borrelia burgdorferi , the causative agent of Lyme disease , and the TLR1/TLR2-specific agonist PAM ( 3 ) CSK ( 4 ) . Regulation TNF TLR8 19322177 2064497 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ) , but not [TNF] , in *response* to ligands . Regulation TNF TLR8 19890037 2165900 MAPKs are crucial for [TNF-alpha] and IL-6 production by innate immune cells in *response* to ligands . Regulation TNF TLR8 20059544 2248072 Results obtained using V. vulnificus type strain ATCC 27562 showed that ( 1 ) TLR4 signaling is myeloid differentiation factor 88 dependent and plays a key role in TNFalpha production by mouse blood and splenocytes stimulated ex vivo with inactivated V. vulnificus cells , ( 2 ) TLR4 signaling is deleterious in a mouse model of V. vulnificus infection , ( 3 ) signaling by TLR ( s ) , exclusive of TLR4 , is needed to eradicate infection , and ( 4 ) the mediated [TNFalpha] *response* plays a critical role in determining the outcome of infection . Regulation TNF TLR8 21947541 2546884 In conclusion , we report gender-specific associations with TLR7 and polymorphisms and [TNF-a] cellular *responses* to its ligand . Regulation TNF TLR8 21968712 2617058 In this report , we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages , leading to incapability for the production of inflammatory cytokines like [tumor necrosis factor (TNF)-a] and interleukin (IL)-1ß in *response* to stimulation . Regulation TNF TLR8 23504259 2809809 Adenosine signaling suppresses the *dependent* expression of [TNF-a] , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Regulation TNF TLR8 24771857 2937088 At the cellular level , Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower [TNF-a] and higher IL-10 in *response* to ligands than did their WT counterparts . Regulation TNF TLR9 15485822 1347324 *regulates* [tumor necrosis factor-alpha] expression by different mechanisms . Regulation TNF TLR9 15994412 1447025 In wild-type ( Wt ) mice injected with heat inactivated E. coli , hepatic TLR4 and TLR2 proteins were up-regulated with *dependent* increases in transcript levels for [tumor necrosis factor] ( TNF-alpha ) , interleukin 6 , nitric oxide synthase-II ( iNOS ) , and NADPH oxidase 2 (Nox2) . Regulation TNF TLR9 17092567 1732090 Lack of IFN-alpha/betaR signaling also blocked production of IFN-gamma and [TNF-alpha] in *response* to activation . Regulation TNF TLR9 17548579 1784242 in turn , extracellular HMGB1 accelerates the delivery of CpG-ODNs to its receptor , leading to a *dependent* augmentation of IL-6 , IL-12 , and [TNFalpha] secretion . Regulation TNF TLR9 17664270 1793908 JNK controls [tumor necrosis factor] alpha production and mediated macrophage *responses* to Borrelia burgdorferi , the causative agent of Lyme disease , and the TLR1/TLR2-specific agonist PAM ( 3 ) CSK ( 4 ) . Regulation TNF TLR9 19322177 2064498 Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ) , but not [TNF] , in *response* to ligands . Regulation TNF TLR9 19890037 2165901 MAPKs are crucial for [TNF-alpha] and IL-6 production by innate immune cells in *response* to ligands . Regulation TNF TLR9 20059544 2248073 Results obtained using V. vulnificus type strain ATCC 27562 showed that ( 1 ) TLR4 signaling is myeloid differentiation factor 88 dependent and plays a key role in TNFalpha production by mouse blood and splenocytes stimulated ex vivo with inactivated V. vulnificus cells , ( 2 ) TLR4 signaling is deleterious in a mouse model of V. vulnificus infection , ( 3 ) signaling by TLR ( s ) , exclusive of TLR4 , is needed to eradicate infection , and ( 4 ) the mediated [TNFalpha] *response* plays a critical role in determining the outcome of infection . Regulation TNF TLR9 20963937 2338324 B cells from HIV infected patients with primary central nervous system lymphoma display an activated phenotype and have a blunted [TNF-a] *response* to triggering . Regulation TNF TLR9 21115691 2357911 We show that IL-1R type I (IL-1RI) is essential for *dependent* activation of [tumor necrosis factor] receptor associated factor 3 ( TRAF3 ) and for production of the antiinflammatory cytokines IL-10 and type I interferon ( IFN ) . Regulation TNF TLR9 21968308 2492715 To detect expression and its *effect* on the secretion of MCP-1 and [TNF-a] after mouse microglia ( BV2 ) were infected by hepatitis C virus ( HCV ) , and to explore the mechanism of HCV induced central nervous system ( CNS ) infection . Regulation TNF TLR9 21968712 2617059 In this report , we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages , leading to incapability for the production of inflammatory cytokines like [tumor necrosis factor (TNF)-a] and interleukin (IL)-1ß in *response* to stimulation . Regulation TNF TLR9 23504259 2809810 Adenosine signaling suppresses the *dependent* expression of [TNF-a] , IL-12 , IFN-? , and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10 . Regulation TNF TLR9 24771857 2937089 At the cellular level , Kupffer cells and peritoneal macrophages isolated from KO mice expressed higher levels of M2 markers and produced lower [TNF-a] and higher IL-10 in *response* to ligands than did their WT counterparts . Regulation TNF TMED7 12421491 1013566 [ The *effect* of cyclin kinase inhibitor on [tumor necrosis factor-alpha] induced mesangial cell proliferation ] . Regulation TNF TNFRSF1A 11279049 819486 These data show that [TNF-alpha] decreases AQP5 mRNA and protein expression and that the molecular pathway for this effect *involves* and activated NF-kappaB . Regulation TNF TNFRSF1A 11513085 849124 Preincubation with antibody against TNF receptor type 1 (TNFR1) or TNF receptor type 2 reduced the specific binding by 95 and 15 % , respectively , suggesting a dominating *role* of in 125I labeled [TNFalpha] ( 125I-TNFalpha ) binding . Regulation TNF TNFRSF1A 11588035 866577 Finally , the results showed that *plays* an important role in mediating TNF-alpha induced changes in [TNF-alpha] and GM-CSF mRNA stability . Regulation TNF TNFRSF1A 15647744 1363626 In summary , these data show that IPC produces neuronal upregulation of TACE and , and that the pathway [TACE/TNF-alpha/TNFR1/NF-kappaB] is *involved* in IT . Regulation TNF TNFRSF1A 16385659 1494175 To determine the functional *roles* of and TNFR2 on [TNF] induction , we investigated NF-kappaB activation and TNF-alpha induction after neutralizing TNFR1 and TNFR2 by an antibody treatment . Regulation TNF TNFRSF1A 20370892 2273375 However , the *role* of in mediating the [TNFalpha] effects in RA has not been elucidated and conflicting data exist in experimental arthritis models . Regulation TNF TNFRSF1A 21670314 2451216 We found that in monocytes [TNF] induces sustained Nrf2 activation and Nrf2 cytoprotective gene induction in a *dependent* manner . Regulation TNF TNFRSF1A 8395024 228471 To investigate the *role* of in beneficial and detrimental activities of [TNF] , we generated TNFR1-deficient mice by gene targeting . Regulation TNF TNFRSF1A 8776958 379911 It is assumed that soluble and II ( sTNF-RI , II ) *play* important roles in the regulation of [tumor necrosis factor alpha (TNF-alpha)] activity . Regulation TNF TNFRSF1A 8955207 401359 These data indicate that *plays* a major role in [TNF] activation of the hypothalamus-pituitary-adrenal axis and in the centrally mediated induction of peripheral IL-6 by TNF , but p75 , despite having little IL-6 inductive properties by itself , seems to potentiate p55 induction of IL-6 . Regulation TNF TNFRSF1B 16385659 1494176 To determine the functional *roles* of TNFR1 and on [TNF] induction , we investigated NF-kappaB activation and TNF-alpha induction after neutralizing TNFR1 and TNFR2 by an antibody treatment . Regulation TNF TNFRSF1B 16939569 1609304 The *effect* of on [TNF-alpha] activity was evaluated using both a TNF-alpha bioassay and an enzyme linked immunoassay . Regulation TNF TNFRSF1B 16951943 1673320 There is an association between [TNF] gene promoter polymorphisms and *response* to in rheumatoid factor negative polyarticular JIA . Regulation TNF TNFRSF1B 17046178 1674725 In addition , [TNF-alpha] released from macrophages and TNF-receptor (TNFR) 1 and mRNA expression in lymphocytes were closely *involved* in this apoptosis induction . Regulation TNF TNFRSF1B 20443835 2009623 We also examined the *effect* of on [TNF] stability and the results showed that there was a two-fold increase in the mass of bioactive homotrimeric TNF when the molar ratio of TNF to etanercept was approximately 200 : 1 . Regulation TNF TNFRSF1B 21224756 2452950 This positive *effect* of on spinal cord injury is probably attributable to the suppression of [TNF-a] , TNFR1 , TNFR2 , and activated caspase-3 and caspase-8 overexpressions , and the inhibition of neuronal and oligodendroglial apoptosis . Regulation TNF TNFRSF1B 24313444 2916861 We aimed to investigate the in vivo *effect* of on synovial expression of [TNF-a] and LT-a . Regulation TNF TNFRSF1B 8912006 395373 Using human TNF mutants with selective receptor binding properties it has been demonstrated in neutrophils and endothelium that is *involved* in the mediation of the proinflammatory activity of TNF by facilitating the p55 [TNF] receptor ( TNFR55 ) . Regulation TNF TNFRSF9 23437083 2744477 Furthermore , the mechanisms that account for the *effect* of signaling on [TNF-a] production were based on a decrease of TNF-a production by APC and , perhaps , on the increase in APC apoptosis . Regulation TNF TNFRSF9 23557259 2777812 The p38 MAPK activation and [TNF-a] production were *controlled* by p38 MAPK and signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation TNF TNFSF10 18838202 1988249 Thus , FLIPL and FLIPS exerted differential effects in myeloid leukemic cell lines in *response* to and [TNF-alpha] . Regulation TNF TNFSF11 19718038 2133597 Irf8-/- osteoclast precursors underwent increased osteoclastogenesis in *response* to and [tumor necrosis factor-alpha (TNF-alpha)] . Regulation TNF TNFSF12 23469193 2750321 In vitro , we demonstrated that only inhibited ovarian cancer HO-8910PM cell proliferation in combination with tumor necrosis factor-a (TNF-a) , whereas either TWEAK or [TNF-a] alone did n't *affect* HO-8910PM cell growth . Regulation TNF TNS1 3131074 83445 Thus it appears that contains another cytotoxic molecule and that [TNF] itself may *act* indirectly in vivo , perhaps by activating an effector cell . Regulation TNF TP53 11132130 760212 This implies that directly or indirectly represses TNFalpha gene expression and that modification of p53 mRNA stability or phosphorylation of p53 protein after UV may be *responsible* for [TNFalpha] induction in the membrane . Regulation TNF TP53 11314015 806344 Interestingly , we found that injection of TNF readily induced IEC apoptosis and that radiation induced a *dependent* increase in the intestinal level of [TNF] . Regulation TNF TP53 17599062 1774550 We also demonstrate that [TNF-alpha] is upregulated in *response* to and p53 inducing genotoxic stress , in a CDIP dependent manner . Regulation TNF TP53 20228833 2254450 We examined the effects of these mutations on interferon ( IFN ) induction , [tumor-necrosis factor (TNF)alpha] *response* , activity and apoptosis . Regulation TNF TP53 21663590 2464779 Our findings highlight the *regulation* of [LITAF/TNF-a] by and its short peptide 162-motif . Regulation TNF TP53 23108402 2837679 Current knowledge states that in certain cell types , 5-FU induced stress is signaling through a *dependent* induction of [tumor necrosis factor-receptor] oligomerization required for death inducing signaling complex formation and caspase-8 activation . Regulation TNF TP53 23628949 2784416 Role of mediated *regulation* of NF-?ß and [TNF-a] was elucidated by Western blot analysis . Regulation TNF TP53 9405367 469778 Taken together , the present findings show that the cytotoxic activity of [TNF] towards oncoprotein expressing cells *involves* and an impaired signaling for survival in such cells . Regulation TNF TPM1 23623504 2823151 We investigated the *effects* of valproic acid ( VPA ) and on the blood levels of interleukin (IL)-1a , IL-1ß , IL-6 , IL-10 , and [TNF-a] in children with idiopathic generalized and partial epilepsy . Regulation TNF TPM2 23623504 2823152 We investigated the *effects* of valproic acid ( VPA ) and on the blood levels of interleukin (IL)-1a , IL-1ß , IL-6 , IL-10 , and [TNF-a] in children with idiopathic generalized and partial epilepsy . Regulation TNF TPM3 23623504 2823153 We investigated the *effects* of valproic acid ( VPA ) and on the blood levels of interleukin (IL)-1a , IL-1ß , IL-6 , IL-10 , and [TNF-a] in children with idiopathic generalized and partial epilepsy . Regulation TNF TPM4 23623504 2823154 We investigated the *effects* of valproic acid ( VPA ) and on the blood levels of interleukin (IL)-1a , IL-1ß , IL-6 , IL-10 , and [TNF-a] in children with idiopathic generalized and partial epilepsy . Regulation TNF TRAF1 12370254 995686 *Regulation* of the subcellular localization of [tumor necrosis factor] receptor associated factor ( TRAF)2 by reveals mechanisms of TRAF2 signaling . Regulation TNF TRAF2 23998902 2862135 The E3 ubiquitin ligase plays a crucial *role* for [TNF-a] mediated signaling since NF-?B activation by TNF-a is at least partially mediated by TRAF2 . Regulation TNF TRAF6 17055451 1636507 While TNF-alpha exerts various biological effects including cell death , the *role* of in the [TNF-alpha] signaling remains to be unclear . Regulation TNF TREM1 22642593 2604724 Our finding that *controls* the production of IL-8 and [TNF-a] in U937 foam cells defines a potentially critical role of TREM-1 in the pathogenesis of atherosclerosis and implicates TREM-1 as a potential therapeutic target for the disease . Regulation TNF TRG 20423301 2288007 Higher values or a higher tendency of the glucokinase (GLK)/glucose-6-phosphatase (G6Pase) ratio in the liver and lower levels of the serum tumor necrosis factor (TNF)-alpha in the TRG- and NA-fed mice , compared to the control mice , suggested that the *regulation* of GLK and G6Pase , and [TNF-alpha] production by and NA are closely related in suppressing the progression of diabetes in the KK-A ( y ) mice . Regulation TNF TSHB 2551628 119044 Characterization of [tumor necrosis factor-alpha] receptors in human and rat thyroid cells and *regulation* of the receptors by . Regulation TNF TTC1 9085232 421436 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC12 9085232 421445 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC13 9085232 421456 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC14 9085232 421446 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC16 9085232 421457 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC17 9085232 421449 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC18 9085232 421461 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC19 9085232 421453 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC22 9085232 421454 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC23 9085232 421450 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC24 9085232 421462 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC25 9085232 421448 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC26 9085232 421443 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC27 9085232 421452 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC28 9085232 421458 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC29 9085232 421459 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC3 9085232 421437 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC31 9085232 421451 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC32 9085232 421463 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC33 9085232 421460 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC34 9085232 421465 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC36 9085232 421464 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC37 9085232 421444 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC38 9085232 421455 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC4 9085232 421438 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC40 9085232 421447 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC5 9085232 421439 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC6 9085232 421440 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC8 9085232 421441 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TTC9 9085232 421442 In order to explore some aspects of the mechanism involved , we tested the *effect* of on LPS induced [TNF alpha] secretion by human monocytes in vitro . Regulation TNF TXN 10985667 732360 Secondly , we analysed whether redox stimulation by alone or in combination with the phorbol ester PMA *affected* the expression and release of [TNFalpha] . Regulation TNF UCN2 21454316 2463644 the *effects* of or Ucn 3 on tumour necrosis factor ( [TNF-a] ) and interleukin ( IL-4 ) secretion from cultured endometrial stromal cells was studied . Regulation TNF UCN2 22000474 2513129 *Effects* of and urocortin 3 on IL-10 and [TNF-a] expression and secretion from human trophoblast explants . Regulation TNF UCN2 22000474 2513144 The present study showed that and Ucn3 differentially *regulate* the LPS induced [TNF-a] and IL-10 expression and secretion in trophoblast explants acting through CRH-R2 . Regulation TNF UCN3 21454316 2463643 the *effects* of Ucn 2 or on tumour necrosis factor ( [TNF-a] ) and interleukin ( IL-4 ) secretion from cultured endometrial stromal cells was studied . Regulation TNF UCN3 22000474 2513128 *Effects* of urocortin 2 and on IL-10 and [TNF-a] expression and secretion from human trophoblast explants . Regulation TNF UCN3 22000474 2513143 The present study showed that Ucn2 and differentially *regulate* the LPS induced [TNF-a] and IL-10 expression and secretion in trophoblast explants acting through CRH-R2 . Regulation TNF UGCG 20656372 2381195 Stimulation of various differently *affected* the expressions of the cytokines IL-1ß , IL-6 , and [TNF-a] in control cells and in cells activated by bacterial endotoxin ( LPS ) . Regulation TNF UMOD 9120306 423859 *Effects* of and Tamm-Horsfall protein (THP) , the most abundant proteins in the urine of pregnant and normal women , respectively , on the induction of [TNF-alpha] secretion and tissue factor ( TF ) expression of human monocytes were studied . Regulation TNF UNC13A 21805469 2495251 Taken together , these findings demonstrate that Rab37 interacts with to *control* [TNF-a] secretion from activated macrophages . Regulation TNF VAMP8 19564343 2104202 Furthermore , *regulates* the release of [TNF-alpha] and beta-hexosaminidase triggered by fMLP , and VAMP8 ( -/- ) mice are protected from fMLP induced peritonitis . Regulation TNF VCAM1 22996381 2740302 Curcumin *regulates* the expression of inflammatory cytokines ( e.g. , [TNF] , IL-1 ) , growth factors ( e.g. , VEGF , EGF , FGF ) , growth factor receptors ( e.g. , EGFR , HER-2 , AR ) , enzymes ( e.g. , COX-2 , LOX , MMP9 , MAPK , mTOR , Akt ) , adhesion molecules ( e.g. , ELAM-1 , ICAM-1 , ) , apoptosis related proteins ( e.g. , Bcl-2 , caspases , DR , Fas ) , and cell cycle proteins ( e.g. , cyclin D1 ) . Regulation TNF VEGFA 16557232 1555671 Cells were selected , cloned , and then characterized by light and electron microscopy ( EM ) , *response* to ( VEGF ) , and [tumour necrosis factor (TNF)alpha] , expression of endothelial markers by focused gene array , immunofluorescence and Western blotting , and formation and behaviour of monolayers . Regulation TNF VIP 10340296 616055 beta-endorphin effects glucose metabolism in the limbic system , CCK increases the release of beta-endorphin from the anterior pituitary , NPY is a powerful anxiolytic that regulates beta-endorphin and insulin , while indirectly *regulates* the expression of [TNF-alpha] through the inhibition of interleukin-4 (IL-4) . Regulation TNF VIP 14657510 1218755 The *effects* of on basal or tumour necrosis factor alpha (TNF-alpha) stimulated production of CCL2 ( MCP-1 , monocyte chemotactic protein 1 ) , CXCL8 [ interleukin (IL)-8 ] , IL-6 and [TNF-alpha] were studied by specific ELISAs ( enzyme linked immunosorbent assays ) . Regulation TNF VIP 16319097 1546930 The *effects* of on basal or [TNF-alpha] or lipopolysaccharide (LPS) induced TLR2 , TLR4 and MyD88 expression and its effects on TLR4 mediated CCL2 and CXCL8 chemokine production were studied by reverse transcription-polymerase chain reaction , western blotting and enzyme linked immunosorbent assay . Regulation TNF VIP 8982099 403793 Differential *effects* of gastrin releasing peptide , neuropeptide Y , somatostatin and on interleukin-1 beta , interleukin-6 and [tumor necrosis factor-alpha] production by whole blood cells from healthy young and old subjects . Regulation TNF VIP 9726844 529837 In this study , we investigated the *effect* of on IL-12 , [TNF alpha] and nitric oxide ( NO ) production in macrophages following activation with lipopolysaccharide (LPS) or superantigens . Regulation TNF WAS 1334476 205875 The present study evaluated the *effect* in vitro of on soluble [TNF-alpha] production by cultured murine peritoneal macrophages . Regulation TNF WAS 8732433 374078 The present studies have examined the mechanism of 's *effects* on [tumor necrosis factor alpha (TNF-alpha)] , a major macrophage produced cytokine and an important mediator involved in cytokine networks and in host defense mechanisms . Regulation TNF WDR61 12381675 997382 The lipid mediator *plays* an important role in the phagocytosis of particles , including bacteria , and consequent production of pro-inflammatory cytokines , such as [TNF-alpha] and IL-8 . Regulation TNF WDR61 15316260 1286203 The aim of this study was to determine [tumor necrosis factor alpha (TNF-alpha)] and interleukin-6 (IL-6) release in *response* to induction in peripheral blood mononuclear cells ( PBMCs ) from chronic hepatitis B virus ( HBV ) carriers . Regulation TNF WDR61 15316260 1286223 Compared with group A , PBMCs from naturally immune subjects and chronic HBV carriers produced significantly higher amounts of [TNF-alpha] and IL-6 in *response* to . Regulation TNF WDR61 1613396 191116 Moreover , 6 day- or 7 day differentiated HL-60 cells showed a further increase in [TNF] production in *response* to , and the response was bimodal , similar to that of the less dense subset of monocytes , with peaks at 10 ( -14 ) and 10 ( -7 ) M PAF . Regulation TNF WDR61 1668107 176695 The *effect* of and of two specific PAF antagonists on [tumor necrosis factor (TNF)] induced superoxide production by human polymorphonuclear neutrophils ( PMN ) was examined . Regulation TNF WDR61 1873355 165253 Further , the *role* of released in response to a challenge with LPS in the regulation of [TNF] and IL-6 production was investigated . Regulation TNF WDR61 1873355 165263 *played* a central role in the [TNF] release in the in vitro experiments . Regulation TNF WDR61 2545780 114302 The *effect* of on [TNF] production by rat alveolar macrophages ( AM ) and the role of endogenous leukotriene B4 (LTB4) in this regulation were examined . Regulation TNF WDR61 7821968 285560 In the present study we investigated the *effects* of endotoxin and on [TNF] gene expression . Regulation TNF WDR61 8009983 243909 The results showed that might *play* an important role in the production of [TNF] . Regulation TNF WDR61 8423096 210792 It was concluded that *plays* an important role in endotoxin induced [TNF] production and mortality . Regulation TNF WDR61 8653713 364653 The effect of platelet activating factor (PAF) on experimental pulmonary metastasis by the B16F10 murine melanoma and the possible *involvement* of in the activities of [tumor necrosis factor alpha (TNF-alpha)] and interleukin 1alpha (IL-1alpha) in tumor metastasis were investigated . Regulation TNF WNK1 10938077 737412 [Tumor necrosis factor] alpha induced phosphorylation of on Ser529 is *controlled* by casein kinase II . Regulation TNF WNT1 11203701 785450 [TNF] signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is *regulated* by and activin during tooth organogenesis . Regulation TNF WNT1 22923429 2837622 Studies assessing mechanisms of estrogen action on bone in humans have identified effects of estrogen on RANKL expression by several different cell types in the bone microenvironment , a *role* for [TNF-a] and IL-1ß in mediating effects of estrogen deficiency on bone , and possible regulation of the inhibitor , sclerostin , by estrogen . Regulation TNF WNT1 24286133 2877304 Here , we have demonstrated that signaling *regulates* [TNF-a] and that Wnt signaling and TNF-a form a positive-feedback loop in nucleus pulposus cells . Regulation TNF WNT11 11203701 785451 [TNF] signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is *regulated* by and activin during tooth organogenesis . Regulation TNF WNT11 22923429 2837623 Studies assessing mechanisms of estrogen action on bone in humans have identified effects of estrogen on RANKL expression by several different cell types in the bone microenvironment , a *role* for [TNF-a] and IL-1ß in mediating effects of estrogen deficiency on bone , and possible regulation of the inhibitor , sclerostin , by estrogen . Regulation TNF WNT11 24286133 2877305 Here , we have demonstrated that signaling *regulates* [TNF-a] and that Wnt signaling and TNF-a form a positive-feedback loop in nucleus pulposus cells . Regulation TNF WNT16 11203701 785456 [TNF] signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is *regulated* by and activin during tooth organogenesis . Regulation TNF WNT16 22923429 2837629 Studies assessing mechanisms of estrogen action on bone in humans have identified effects of estrogen on RANKL expression by several different cell types in the bone microenvironment , a *role* for [TNF-a] and IL-1ß in mediating effects of estrogen deficiency on bone , and possible regulation of the inhibitor , sclerostin , by estrogen . Regulation TNF WNT16 24286133 2877310 Here , we have demonstrated that signaling *regulates* [TNF-a] and that Wnt signaling and TNF-a form a positive-feedback loop in nucleus pulposus cells . Regulation TNF WNT2 11203701 785452 [TNF] signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is *regulated* by and activin during tooth organogenesis . Regulation TNF WNT2 22923429 2837624 Studies assessing mechanisms of estrogen action on bone in humans have identified effects of estrogen on RANKL expression by several different cell types in the bone microenvironment , a *role* for [TNF-a] and IL-1ß in mediating effects of estrogen deficiency on bone , and possible regulation of the inhibitor , sclerostin , by estrogen . Regulation TNF WNT2 24286133 2877306 Here , we have demonstrated that signaling *regulates* [TNF-a] and that Wnt signaling and TNF-a form a positive-feedback loop in nucleus pulposus cells . Regulation TNF WNT2B 23785285 2802471 Here we show that secretion of and WNT9B and stabilization of ß-catenin ( CTNNB1 ) upon virus infection negatively *regulate* expression of representative inducible genes IFNB1 , IFIT1 and [TNF] in a CTNNB1 dependent effector mechanism . Regulation TNF WNT3 11203701 785453 [TNF] signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is *regulated* by and activin during tooth organogenesis . Regulation TNF WNT3 22923429 2837625 Studies assessing mechanisms of estrogen action on bone in humans have identified effects of estrogen on RANKL expression by several different cell types in the bone microenvironment , a *role* for [TNF-a] and IL-1ß in mediating effects of estrogen deficiency on bone , and possible regulation of the inhibitor , sclerostin , by estrogen . Regulation TNF WNT3 24286133 2877307 Here , we have demonstrated that signaling *regulates* [TNF-a] and that Wnt signaling and TNF-a form a positive-feedback loop in nucleus pulposus cells . Regulation TNF WNT4 11203701 785454 [TNF] signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is *regulated* by and activin during tooth organogenesis . Regulation TNF WNT4 22923429 2837626 Studies assessing mechanisms of estrogen action on bone in humans have identified effects of estrogen on RANKL expression by several different cell types in the bone microenvironment , a *role* for [TNF-a] and IL-1ß in mediating effects of estrogen deficiency on bone , and possible regulation of the inhibitor , sclerostin , by estrogen . Regulation TNF WNT4 24286133 2877308 Here , we have demonstrated that signaling *regulates* [TNF-a] and that Wnt signaling and TNF-a form a positive-feedback loop in nucleus pulposus cells . Regulation TNF WNT6 11203701 785455 [TNF] signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is *regulated* by and activin during tooth organogenesis . Regulation TNF WNT6 22923429 2837627 Studies assessing mechanisms of estrogen action on bone in humans have identified effects of estrogen on RANKL expression by several different cell types in the bone microenvironment , a *role* for [TNF-a] and IL-1ß in mediating effects of estrogen deficiency on bone , and possible regulation of the inhibitor , sclerostin , by estrogen . Regulation TNF WNT6 24123681 2863752 Further functional studies in M. tuberculosis infected macrophages using Wnt6 conditioned medium and Wnt6-deficient macrophages uncovered a *dependent* induction of macrophage Arginase-1 and downregulation of [TNF-a] . Regulation TNF WNT6 24286133 2877309 Here , we have demonstrated that signaling *regulates* [TNF-a] and that Wnt signaling and TNF-a form a positive-feedback loop in nucleus pulposus cells . Regulation TNF WNT9B 23785285 2802470 Here we show that secretion of WNT2B and and stabilization of ß-catenin ( CTNNB1 ) upon virus infection negatively *regulate* expression of representative inducible genes IFNB1 , IFIT1 and [TNF] in a CTNNB1 dependent effector mechanism . Regulation TNF WT1 23225417 2705708 The TCR transduced CD8 ( + ) T-cells produced interferon-? ( IFN? ) and [tumor necrosis factor-a (TNFa)] in *response* to stimulation not only with the modified WT1 ( 235 ) peptide but also with the natural ( 235 ) peptide and lysed modified or natural WT1 ( 235 ) peptide pulsed target cells and endogenously WT1 expressing leukemia cells in a HLA-A*24 : 02-restriction manner . Regulation TNF XCL1 15817686 1397502 An additional stress induced increase in infiltration was observed for neutrophils , in response to TNF-alpha , macrophages , in response to [TNF-alpha] and LTN , and natural killer cells and T cells in *response* to . Regulation TNF XCL1 8762466 374755 Moreover , the *effect* of on production of [tumor necrosis factor (TNF)] from murine peritoneal macrophage was also tested . Regulation TNF XDH 19054643 2017619 Variability in [tumor necrosis factor-alpha] , nitric oxide , and *responses* to endotoxin challenge in heifers : effect of estrous cycle stage . Regulation TNF XDH 21356584 2411434 Modeling the effects of estradiol and progesterone on the acute phase proinflammatory axis : variability in [tumor necrosis factor-a] , nitric oxide , and *responses* to endotoxin challenge in steers . Regulation TNF XPO1 17064665 1649625 Inhibition of *dependent* cellular release of [TNFalpha] could thus provide a novel therapeutic approach for disorders involving excessive TNFalpha release . Regulation TNF XRCC5 9636658 513400 The *role* of , a protein kinase involved in the response to DNA damage , in the activation of NF kappa B by IR and [TNF alpha] was examined . Regulation TNF XRCC6 9636658 513401 The *role* of , a protein kinase involved in the response to DNA damage , in the activation of NF kappa B by IR and [TNF alpha] was examined . Regulation TNF YME1L1 15618187 1357635 Freeze-thaw and cell lysis experiments , along with actinomycin D studies , suggested that CCL20 and [TNF-alpha] are synthesized in *response* to stimulation . Regulation TNF YME1L1 15972514 1423985 In contrast , and at the same time , E2 lowered the [TNF-alpha] *response* to both . Regulation TNF YME1L1 15972514 1423989 Since CCL20/MIP3alpha has antimicrobial activity and is chemotactic for immune cells , these studies suggest that *regulation* of CCL20/MIP3alpha and [TNF-alpha] by E2 and may have profound effects on innate and adaptive immune responses to microbial challenge in the female reproductive tract . Regulation TNF ZFAND6 21810480 2484821 These data indicate that binds to tumor necrosis factor receptor associated factor 2 and that *regulates* [tumor necrosis factor] alpha induced nuclear factor kappaB activation through two distinct domains . Regulation TNF ZFP36 11533235 854624 Mitogen activated protein kinase p38 controls the expression and posttranslational modification of , a *regulator* of [tumor necrosis factor] alpha mRNA stability . Regulation TNF ZFP36 16142751 1454882 The *effects* of on [TNFalpha] expression were examined using an overexpression model of TIS11B in RAW264.7 cells . Regulation TNF ZFP36 16508014 1530269 Mitogen activated protein kinase activated protein kinase 2 *regulates* [tumor necrosis factor] mRNA stability and translation mainly by altering expression , stability , and binding to adenine/uridine-rich element . Regulation TNF ZFP36 16546352 1561932 The ZFP36 gene codes for , a *regulator* of [TNF alpha] . Regulation TNF ZFP36 17606294 1842192 *regulates* TNF [TNF-alpha] mRNA stability via a proteasome dependent mechanism involving the combined action of the ERK and p38 pathways . Regulation TNF ZFP36 8630730 361273 These results indicate a *role* for in regulating [TNF alpha] synthesis , secretion , turnover , or action . Regulation TNF ZGLP1 12437983 1016206 The current study has established the fact that glucose , , insulin , T ( 3 ) , HB-EGF , and [TNF-alpha] all positively *regulate* the PDX1 gene promoter in pancreatic beta-cells . Regulation TNFAIP6 TNF 15189690 1256730 To explore the relationship between the differential expression of TSG-6 and adipocyte differentiation , adipogenesis and obesity , the present study aimed to investigate the changes of TSG-6 gene expression during 3T3-L1 preadipocyte differentiation and to analyze the regulative *role* of on [TSG-6] gene expression in matured 3T3-L1 adipocytes . Regulation TNFAIP6 TNF 15189690 1256732 The inhibition *effect* of on [TSG-6] gene mRNA expression generally tended to be reinforced with the increasing concentrations of TNF-alpha and the elongation of time course , except for the period of 6 - 24 h after the stimulation of 10.0 ng/ml TNF-alpha . Regulation TNFAIP6 TNF 15189690 1256733 The inhibitory *effect* of on [TSG-6] gene expression is generally dose correlated . Regulation TNFAIP6 TNF 21774025 2467220 A functional study of TNF demonstrated that depletion of endogenous TNF decreased oocyte competence and TNFAIP6 expression in cumulus cells , while in IVM medium *regulated* [TNFAIP6] expression in cumulus cells . Regulation TNFRSF11B ARSA 17664058 1793894 To investigate the effect of L-ascorbic acid (AsA) on osteoblast differentiation , we examined the *effects* of on in vitro osteoblastic differentiation markers such as collagen synthesis , alkaline phosphatase (ALP) activity , and receptor activator of nuclear factor-kappaB ligand ( RANKL ) and [osteoprotegerin (OPG)] expression . Regulation TNFRSF11B IL1B 17009257 1634047 In addition , interface membrane fibroblasts expressed RANKL and [osteoprotegerin] in *response* to stimulation with conditioned media , TNFalpha , or . Regulation TNFRSF11B IL1B 17443309 1737106 The *effects* of and TNF-alpha on [OPG] expression were characterised by northern blot and immunoassay . Regulation TNFRSF11B IL1B 17501665 1783808 We also examined whether [OPG] production in *response* to influences TRAIL induced apoptosis in MG-63 cells . Regulation TNFRSF11B IL1B 17501665 1783815 We also showed a small transcriptional and a possible post-transcriptional or translational *regulation* of [OPG] by . Regulation TNFRSF11B IL1B 20204061 2181000 Therefore , we examined the *effect* of and/or celecoxib on the expression of macrophage colony stimulating factor ( M-CSF ) , receptor activator of NF-kappaB ligand ( RANKL ) , and [osteoprotegerin (OPG)] in human chondrocytes , and the indirect effect of IL-1beta on osteoclast-like cell formation using RAW264.7 cells . Regulation TNFRSF11B IL1B 20225238 2243920 *Effect* of , PGE ( 2 ) , and TGF-beta1 on the expression of [OPG] and RANKL in normal and osteoporotic primary human osteoblasts . Regulation TNFRSF11B TGM2 24265865 2869851 All together , [OPG] and Tgase-2 is induced by IL-1ß or TPA in MG-63 cells and is *involved* in OPG expression in MG-63 cells . Regulation TNFRSF11B TLR7 12611893 1085400 The two ligands do not *affect* [osteoprotegerin] expression in osteoblasts . Regulation TNFRSF11B TNF 11162596 782268 Using this ELISA , the amount of OPG secreted from human bone marrow stromal cells was clearly detectable , and the secretion of [OPG-protein] was potently *regulated* by prostaglandin E ( 2 ) , forskolin , phorbol 12,13 di butyrate , IL-1 alpha , , and dexamethasone . Regulation TNFRSF11B TNF 12930661 1132342 To investigate the *effects* of LPS and/or on periodontal ligament cell ( PDLC ) proliferation and [OPG] secretion . Regulation TNFRSF11B TNF 14653607 1173783 Endothelial cell [OPG] mRNA levels were *regulated* by and VEGF , but not by hypoxia . Regulation TNFRSF11B TNF 17009257 1634046 In addition , interface membrane fibroblasts expressed RANKL and [osteoprotegerin] in *response* to stimulation with conditioned media , , or IL-1beta . Regulation TNFRSF11B TNF 17443309 1737105 The *effects* of IL-1beta and on [OPG] expression were characterised by northern blot and immunoassay . Regulation TNFRSF11B TNF 18083042 1854660 Characterization of synovial cell clones isolated from rheumatoid arthritis patients : possible *involvement* of in reduction of [osteoprotegerin] in synovium . Regulation TNFRSF11B TNF 22922824 2672503 Expression of [OPG] and RANKL was not *affected* by but modulated by trauma . Regulation TNFRSF11B TNF 23490134 2799548 Differential expression and mediated *regulation* of [TNFRSF11b/osteoprotegerin] production by human melanomas . Regulation TNFRSF11B TNF 9703945 525536 In this report we have examined the *effect* of and tumor necrosis factor-beta (TNF-beta) on [OPG] mRNA levels in the human osteosarcoma cell line MG-63 . Regulation TNFRSF11B TNFSF10 21660951 2442620 Since MSC , fibroblasts and endothelial cells represent key elements of the normal and tumor microenvironment and express detectable levels of surface TRAIL receptors , we investigated the *effect* of on [OPG] release . Regulation TNFRSF1A EPHB2 18442799 1900633 In this study , we show that and p38 MAP kinase are *involved* in the downregulation of cell surface [TNF-R1] upon exposure to Ac-CHX and the subsequent inhibition of TNF-alpha induced NF-kappaB activation . Regulation TNFRSF1A IL1B 11152574 759001 Both TNF-alpha and upregulated the gene expression of TNFR75 and did not *affect* that of [TNFR55] . Regulation TNFRSF1A TNF 11152574 759000 Both and IL-1 beta upregulated the gene expression of TNFR75 and did not *affect* that of [TNFR55] . Regulation TNFRSF1A TNF 12056510 951862 did not *affect* [TNFR-1] expression in the liver and resulted in time dependent up-regulation of iNOS , IL-1beta and HO-1 . Regulation TNFRSF1A TNF 12847699 1109057 , however , did not *affect* levels of TNF and [TNFRI] at the concentrations tested . Regulation TNFRSF1A TNF 15115707 1279365 Both kinases associate with [TNFR-1] in *response* to and are required for TNFR-1 serine phosphorylation , NF-kappaB activation , and inhibition of apoptosis . Regulation TNFRSF1A TNF 15115707 1279371 Coimmunoprecipitation studies established that PI 3-kinase , delta-PKC , and [TNFR-1] formed a signal complex in *response* to . Regulation TNFRSF1A TNF 15240695 1270342 Immunoprecipitation of cells with Syk Abs showed *dependent* association of Syk with both [TNFR1] and TNFR2 ; Regulation TNFRSF1A TNF 15647744 1363628 In summary , these data show that IPC produces neuronal upregulation of TACE and [TNFR1] , and that the pathway is *involved* in IT . Regulation TNFRSF1A TNF 15788779 1386314 Here we demonstrate that *acts* on neuronal [TNFR1] receptors to preferentially exocytose glutamate receptor 2-lacking AMPA receptors through a phosphatidylinositol 3 kinase dependent process . Regulation TNFRSF1A TNF 16958678 1611146 Hyperhomocysteinemia , ER stress and pathological changes of alcohol were minimally affected by absence of [tumor necrosis factor receptor 1 (TNFR1)] and the effect of betaine was also *independent* of signaling . Regulation TNFRSF1A TNF 18981220 2015196 Consistent with this , TRAF2 phosphorylation is not required for its recruitment to the [TNFR1] complex in *response* to stimulation but is required for its association with a cytoplasmic complex containing RIP1 and IKK . Regulation TNFRSF1A TNF 19643112 2143167 The also *acts* on presynaptic [TNF-R1] to increase the amount of glutamate released by each nerve terminal impulse . Regulation TNFRSF1A TNF 22417305 2572670 CD4+ CD26- lymphocytes from the peripheral blood of patients with SzS and healthy controls were negatively selected using CD4 and CD26 magnetic beads and analysed for expression of [TNFR1] , TNFR2 , IER3 expression , and ROS production in *response* to at an apoptotic dose . Regulation TNFRSF1A TNF 23677929 2801129 Finally , our data suggest that the IRA isoform and its association with [TNF-R1] or IGF-IR confers proliferative advantage to VSMCs , mainly in *response* to or IGF-II , which might be of significance in the early atherosclerotic process . Regulation TNFRSF1A TNF 7535144 287784 Whereas [TNFR55] is involved in most observed *responses* to , signaling of TNFR75 appears to be restricted to inhibitory effects on primitive progenitors . Regulation TNFRSF1A TNF 9637537 513876 this finding indicates that *acts* on the [TNFR1] of host cells but does not act on platelets . Regulation TNFRSF1A TNFSF10 16462206 1522804 Our results provide the first evidence for the caveolar localization of [TNF-R1] and DR5 and the coordinated redistribution among membrane fractions of several death receptors in *response* to . Regulation TNFRSF1B TNF 15240695 1270343 Immunoprecipitation of cells with Syk Abs showed *dependent* association of Syk with both TNFR1 and [TNFR2] ; Regulation TNFRSF1B TNF 22417305 2572671 CD4+ CD26- lymphocytes from the peripheral blood of patients with SzS and healthy controls were negatively selected using CD4 and CD26 magnetic beads and analysed for expression of TNFR1 , [TNFR2] , IER3 expression , and ROS production in *response* to at an apoptotic dose . Regulation TNFRSF1B TNF 8575836 340881 and anti-TNF-R2 monoclonal antibodies ( mAbs ) inhibited monocyte ability to present PPD for IFN gamma production which suggested that endogenously produced TNF by monocytes had to be released and *acted* on [TNF-R2] on the monocyte surface . Regulation TNFRSF9 TNF 23557259 2777826 The p38 MAPK activation and production were *controlled* by p38 MAPK and [CD137] signaling in DENV infected HepG2 cells as activated p38 MAPK , TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells . Regulation TNFSF10 AKT1 12807432 1101899 Moreover , [TRAIL] increased CREB phosphorylation and phospho-CREB DNA binding activity in a phosphatidylinositol 3-kinase (PI <3K)/Akt> *dependent* manner . Regulation TNFSF10 AKT2 12807432 1101900 Moreover , [TRAIL] increased CREB phosphorylation and phospho-CREB DNA binding activity in a phosphatidylinositol 3-kinase (PI <3K)/Akt> *dependent* manner . Regulation TNFSF10 AKT3 12807432 1101901 Moreover , [TRAIL] increased CREB phosphorylation and phospho-CREB DNA binding activity in a phosphatidylinositol 3-kinase (PI <3K)/Akt> *dependent* manner . Regulation TNFSF10 ATF3 21362629 2431724 We also observed that DIM-C-pPhOCH ( 3 ) induced Fas ligand and tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) and induction of [TRAIL] was *dependent* . Regulation TNFSF10 BCL2 10760520 683615 Thus , [TRAIL] engages a death pathway that is at least partially routed via the mitochondria , but in contrast with other stimuli that engage this pathway , TRAIL induced cytochrome c release is not *regulated* by . Regulation TNFSF10 CD40 19906199 2161870 The *effect* of microenvironmental signals on [TRAIL-] and drug induced apoptosis in follicular lymphoma cells . Regulation TNFSF10 CFLAR 12556488 1051672 Our results show that c-FLIP ( L ) and ( S ) potently *control* [TRAIL] responses , both by distinct regulatory features , and further imply that the differentiation state of malignant cells determines their sensitivity to death receptor signals . Regulation TNFSF10 CUX1 20442202 2288118 The *effect* of on [TRAIL-] ( tumour necrosis factor related apoptosis inducing ligand ) and drug induced apoptosis was analysed using overexpression and knock-down strategies . Regulation TNFSF10 DDX58 22087337 2509093 *plays* a key role in the induction of IFN and [TRAIL] by viruses and apoptosis of primary human hepatocytes via activation of the TRAIL mediated pathway . Regulation TNFSF10 EGR1 14560009 1154028 family members *regulate* nonlymphoid expression of Fas ligand , [TRAIL] , and tumor necrosis factor during immune responses . Regulation TNFSF10 EGR2 14560009 1154029 family members *regulate* nonlymphoid expression of Fas ligand , [TRAIL] , and tumor necrosis factor during immune responses . Regulation TNFSF10 EGR3 14560009 1154030 family members *regulate* nonlymphoid expression of Fas ligand , [TRAIL] , and tumor necrosis factor during immune responses . Regulation TNFSF10 EGR4 14560009 1154031 family members *regulate* nonlymphoid expression of Fas ligand , [TRAIL] , and tumor necrosis factor during immune responses . Regulation TNFSF10 EPHB2 14715858 1197397 A MAPK kinase inhibitor ( U0126 ) could enhance the cytokine induced sensitization of thyroid cells to TRAIL , reinforcing the inhibitory *role* of on [TRAIL] signaling . Regulation TNFSF10 EZH2 23228130 2736620 mediated *regulation* of [TRAIL] : a new target for cancer therapy . Regulation TNFSF10 FADD 17786370 1790999 IFN-alpha induced upregulation of TRAIL protein in the dnFADD expressing Daudi or U266 cells was comparable to their control cells , suggesting that is not *involved* in the IFN-alpha induced upregulation of [TRAIL] . Regulation TNFSF10 FADD 8793301 381057 Activation of apoptosis by [Apo-2 ligand] is *independent* of but blocked by CrmA . Regulation TNFSF10 FGF2 20150555 2227511 Injury and *regulated* [TRAIL] transcriptional activity via 2 specificity protein (Sp)1 elements in the proximal TRAIL promoter , a binding site also shared by nuclear factor (NF)kappaB . Regulation TNFSF10 GRAP2 20877355 2337351 Fenretinide upregulated cell surface expression of tumour necrosis factor related apoptosis inducing ligand ( [TRAIL] ) receptors , FAS and p75 ( NTR ) , in an ASK1- and *dependent* manner . Regulation TNFSF10 HLA-DRB1 15094781 1266302 Sensitization to [TRAIL] *involved* enhanced death receptor expression , activation of Bid and the complete caspases cascade . Regulation TNFSF10 HLA-DRB1 21769428 2476382 However , tests on A549 cells with DR4 siRNA transfection revealed that binding to TRAIL could not *affect* the capacity of [TRAIL] in inducing apoptosis . Regulation TNFSF10 IAPP 19463876 2107324 Here , the *effects* of on the proapoptotic cytokine [TNF-related-apoptosis-inducing-ligand] ( TRAIL ) were tested in the rat gastric mucosa damaged by reserpine administration in vivo . Regulation TNFSF10 IFNB1 14609566 1162496 Simultaneously , we investigated the *effect* of the pleiotropic stimulus , known to target all leukocyte subsets , on [TRAIL] . Regulation TNFSF10 IFNB1 21253524 2359717 *Effects* of on [TRAIL] and Decoy Receptor Expression in Different Immune Cell Populations from MS Patients with Distinct Disease Subtypes . Regulation TNFSF10 IL2 10479402 643445 NK cells were shown to express surface [Apo-2L] in *response* to activation , and this response was restricted to the CD3 ( - ) population of the NK cells . Regulation TNFSF10 IRF3 15994827 1429889 We show that is *involved* in the transcriptional induction of [TRAIL] , a key player in the apoptosis pathway . Regulation TNFSF10 JUN 23686163 2791842 Notch inhibition restores TRAIL mediated apoptosis via *dependent* upregulation of DR4 and DR5 [TRAIL] receptors in MDA-MB-231 breast cancer cells . Regulation TNFSF10 KLRC1 24019170 2882400 *regulates* production of soluble [TRAIL] by ex vivo expanded human ?d T cells . Regulation TNFSF10 KRR1 21372226 2426550 Moreover , although *plays* a minimal role in the activity of [TRAIL] as a single agent , it is required for the synergistic interaction between TRAIL and SM-164 . Regulation TNFSF10 MAP2K1 15757891 1417013 In this study , we show that [TRAIL] induces cell death in human colon adenocarcinoma cells in a *dependent* manner . Regulation TNFSF10 MAP2K2 15757891 1417014 In this study , we show that [TRAIL] induces cell death in human colon adenocarcinoma cells in a *dependent* manner . Regulation TNFSF10 MAP2K3 15757891 1417015 In this study , we show that [TRAIL] induces cell death in human colon adenocarcinoma cells in a *dependent* manner . Regulation TNFSF10 MAP2K4 15757891 1417016 In this study , we show that [TRAIL] induces cell death in human colon adenocarcinoma cells in a *dependent* manner . Regulation TNFSF10 MAP2K5 15757891 1417017 In this study , we show that [TRAIL] induces cell death in human colon adenocarcinoma cells in a *dependent* manner . Regulation TNFSF10 MAP2K6 15757891 1417018 In this study , we show that [TRAIL] induces cell death in human colon adenocarcinoma cells in a *dependent* manner . Regulation TNFSF10 MAP2K7 15757891 1417019 In this study , we show that [TRAIL] induces cell death in human colon adenocarcinoma cells in a *dependent* manner . Regulation TNFSF10 MAP3K7 20062539 2193815 To determine the *role* of in [TRAIL] signalling , we analyzed the effects of adding TRAIL to mouse embryonic fibroblasts ( MEFs ) derived from TAK1 conditional knockout mice . Regulation TNFSF10 MYC 21514380 2423011 Up-regulation of DR5 [TRAIL] receptor and down-regulation of c-FLIP and the promotion of caspase dependent cell death , which contribute to TRAIL sensitization of MDR cells , were *regulated* by the over expressed in the MDR cells . Regulation TNFSF10 NFATC1 21603612 2435902 *regulation* of [TRAIL] expression in human intestinal cells . Regulation TNFSF10 NFKB1 11205254 763514 , although stimulated in these cell lines , does not play a role in the sensitivity of RCC to TRAIL and could *play* other functions in [TRAIL] signaling . Regulation TNFSF10 NFKB1 11313369 805406 The *role* of in [TNF related apoptosis inducing ligand] ( TRAIL ) -induced apoptosis of melanoma cells . Regulation TNFSF10 NFKB1 11544302 855277 The *regulation* of [TRAIL] expression by may represent a general mechanism that contributes to the control of TRAIL mediated apoptosis in T lymphocytes . Regulation TNFSF10 NFKB1 16024612 1435231 Specifically , it is not yet understood how [TRAIL] *controls* activation and overcomes its anti-apoptotic effect . Regulation TNFSF10 NFKB1 19434100 2090349 [TRAIL] receptor mediates inflammatory cytokine release in an *dependent* manner . Regulation TNFSF10 NFKB1 20150555 2227526 We conclude that [TRAIL] induction *involves* FGF-2 , Sp1-phosphorylation and and that TRAIL promotes VSMC proliferation and neointima formation after arterial injury . Regulation TNFSF10 NFKB1 20542572 2301996 Pharmacological inhibition of the transcription factor , NF-kappaB also profoundly decreased TRAIL expression , suggesting that is *involved* in the regulation of [TRAIL] expression in activated human NK cells . Regulation TNFSF10 PIK3C3 12807432 1101902 Moreover , [TRAIL] increased CREB phosphorylation and phospho-CREB DNA binding activity in a *dependent* manner . Regulation TNFSF10 PIK3R4 12807432 1101903 Moreover , [TRAIL] increased CREB phosphorylation and phospho-CREB DNA binding activity in a *dependent* manner . Regulation TNFSF10 PRAME 23228130 2736621 mediated *regulation* of [TRAIL] : a new target for cancer therapy . Regulation TNFSF10 PTEN 23419514 2759918 Moreover , RFP mediated ubiquitination of PTEN inhibits *dependent* activation of [TRAIL] expression and also suppresses its ability to induce apoptosis . Regulation TNFSF10 PTH 16137047 1353318 We observed the regulative *effects* of on the expression of osteoprotegerin (OPG) and osteoprotegerin ligand (OPGL) and their related cytokines ( M-CSF and [TRAIL] ) in human osteoblasts ( HOBs ) . Regulation TNFSF10 RELA 11205254 763515 , although stimulated in these cell lines , does not play a role in the sensitivity of RCC to TRAIL and could *play* other functions in [TRAIL] signaling . Regulation TNFSF10 RELA 11313369 805407 The *role* of in [TNF related apoptosis inducing ligand] ( TRAIL ) -induced apoptosis of melanoma cells . Regulation TNFSF10 RELA 11544302 855278 The *regulation* of [TRAIL] expression by may represent a general mechanism that contributes to the control of TRAIL mediated apoptosis in T lymphocytes . Regulation TNFSF10 RELA 16024612 1435232 Specifically , it is not yet understood how [TRAIL] *controls* activation and overcomes its anti-apoptotic effect . Regulation TNFSF10 RELA 19434100 2090350 [TRAIL] receptor mediates inflammatory cytokine release in an *dependent* manner . Regulation TNFSF10 RELA 20150555 2227527 We conclude that [TRAIL] induction *involves* FGF-2 , Sp1-phosphorylation and and that TRAIL promotes VSMC proliferation and neointima formation after arterial injury . Regulation TNFSF10 RELA 20542572 2301997 Pharmacological inhibition of the transcription factor , NF-kappaB also profoundly decreased TRAIL expression , suggesting that is *involved* in the regulation of [TRAIL] expression in activated human NK cells . Regulation TNFSF10 SP1 18701496 1950475 Using different reporter constructs in conjunction with transcription activity assays and chromatin immunoprecipitation assays , we provide evidence that the is *responsible* for [TRAIL] induction by MS275 alone or in combination with Adriamycin . Regulation TNFSF10 SP1 20150555 2227514 Mutational studies confirmed a *role* for in injury- and FGF-2-inducible [TRAIL] transcription . Regulation TNFSF10 SP1 20150555 2227525 We conclude that [TRAIL] induction *involves* FGF-2 , and NFkappaB and that TRAIL promotes VSMC proliferation and neointima formation after arterial injury . Regulation TNFSF10 SRP14 15356269 1323704 Differential *regulation* of the [TRAIL] death receptors DR4 and DR5 by the . Regulation TNFSF10 SRP19 15356269 1323705 Differential *regulation* of the [TRAIL] death receptors DR4 and DR5 by the . Regulation TNFSF10 SRP54 15356269 1323706 Differential *regulation* of the [TRAIL] death receptors DR4 and DR5 by the . Regulation TNFSF10 SRP68 15356269 1323707 Differential *regulation* of the [TRAIL] death receptors DR4 and DR5 by the . Regulation TNFSF10 SRP72 15356269 1323708 Differential *regulation* of the [TRAIL] death receptors DR4 and DR5 by the . Regulation TNFSF10 SRP9 15356269 1323709 Differential *regulation* of the [TRAIL] death receptors DR4 and DR5 by the . Regulation TNFSF10 TAT 17494085 1761653 In human and RM myeloid immature dendritic cells and macrophages , the virus induced expression of [TRAIL] and other interferon-inducible genes , which did not occur in the same cells from chimpanzee , SM , and AGM , was *dependent* . Regulation TNFSF10 TCF7L2 24379239 2932627 Dominant negative overexpression , however , did not significantly *affect* [TRAIL] receptor expression or recombinant human TRAIL sensitivity . Regulation TNFSF10 TNF 21850048 2468762 The contrasting *regulation* of [TRAIL-] and CD95L induced cell death by could be traced back to the concomitant NF?B mediated upregulation of CD95 and the antiapoptotic FLIP protein . Regulation TNFSF10 TNFRSF11B 16155791 1455580 The *effects* of on [TRAIL] induced apoptosis was investigated by exposing MDA-MB 436 cells to TRAIL , in the presence or absence of OPG , followed by assessment of nuclear morphology . Regulation TNFSF10 TNFRSF1B 9743381 532539 In this study , we show that this enhancement is TNFR60 selective , as neither [TNF related apoptosis inducing ligand/Apo2] ligand- , Apo1/Fas- , ceramide- , nor daunorubicin mediated cell death was *affected* by costimulation of . Regulation TNFSF10 TP53 14614322 1163622 In chemosensitive FL cells , we found that DNA damaging drugs promote apoptosis through *dependent* upregulation of the [TRAIL-DR5] receptor , resulting in activation of caspase-8 and downstream executioner caspases , thereby evading bcl-2 mediated suppression of apoptosis . Regulation TNFSF10 TP53 19226377 2050417 The induced by nutritional stress is biologically active in mediating mitochondrial cell death pathways , but may also be *responsible* for [TRAIL] receptor expression , thereby linking intrinsic and exogenous apoptosis pathways in NASH . Regulation TNFSF10 TRADD 21187341 2407838 Restoration of TRADD in Tradd ( -/- ) MEFs restores TRAIL resistance , indicating that *plays* a survival role in [TRAIL] signaling . Regulation TNFSF11 EPHB2 15670856 1366026 Induction of TRANCE expression by IBMX was partially suppressed by the inhibitors of protein kinase A (PKA) , ERK , and p38 MAPK , suggesting that activation of and p38 MAPK , as well as PKA , is *involved* in [TRANCE] expression by IBMX . Regulation TNFSF11 EPHB2 17549607 1791981 The findings of this investigation suggested that activation of the and the PI3K/Akt pathways and inhibition of p38MAPK pathway were *involved* in [RANKL] expression induced by MIP-1alpha in bone-marrow stromal cells and osteoblasts . Regulation TNFSF11 IL1B 15068113 1232066 We investigated the regulatory *effects* of and prostaglandin E2 ( PGE2 ) on expression of [RANKL] in human periodontal ligament (HPDL) cells and the mechanisms involved in the PGE2 effect . Regulation TNFSF11 IL1B 17009257 1634049 In addition , interface membrane fibroblasts expressed [RANKL] and osteoprotegerin in *response* to stimulation with conditioned media , TNFalpha , or . Regulation TNFSF11 IL1B 20225238 2243922 *Effect* of , PGE ( 2 ) , and TGF-beta1 on the expression of OPG and [RANKL] in normal and osteoporotic primary human osteoblasts . Regulation TNFSF11 MAP2K6 17549607 1791987 The findings of this investigation suggested that activation of the and the PI3K/Akt pathways and inhibition of p38MAPK pathway were *involved* in [RANKL] expression induced by MIP-1alpha in bone-marrow stromal cells and osteoblasts . Regulation TNFSF11 TLR7 17467812 1737377 This study was undertaken to explore the *effect* of signaling in fibroblast-like synoviocytes ( FLS ) on the expression of [RANKL] and induction of osteoclastogenic activity . Regulation TNFSF11 TNF 14969390 1209219 Although critical *roles* of in inflammatory arthritis and [RANKL] in bone resorption have been firmly established , a central controversy remains about the extent to which TNFalpha can compensate for RANKL during osteoclastogenesis and the stage at which RANK signaling is required for osteoclastogenesis . Regulation TNFSF11 TNF 15389885 1324293 Thus , we reasoned that may *regulate* [RANKL] and possibly RANK expression by stromal cells and osteoclast precursors ( OCPs ) , respectively . Regulation TNFSF11 TNF 15668736 1369643 These data suggest that *regulates* [RANKL] expression via IL-1 , and , therefore , IL-1 plays a role in TNF induced periarticular osteolysis . Regulation TNFSF11 TNF 16200600 1463846 , produced by both BXD2 MSFs and BXD2 mouse macrophages , had a strong stimulatory *effect* on [RANKL] expression . Regulation TNFSF11 TNF 16734568 1566219 HPDL cells are capable of secreting M-CSF and expressing [RANKL] in *response* to . Regulation TNFSF11 TNF 17009257 1634048 In addition , interface membrane fibroblasts expressed [RANKL] and osteoprotegerin in *response* to stimulation with conditioned media , , or IL-1beta . Regulation TNFSF11 TNF 20683884 2368083 In contrast , ADAM8 KO mice did not display a bone phenotype in vivo , but unlike WT littermates , they did not increase [RANKL] production , OCL formation , or calvarial fibrosis in *response* to in vivo . Regulation TNFSF11 TNF 21963155 2507341 The purpose of this study was to evaluate the *effect* of ( TNF-a ) on [RANKL] expression in bone marrow adipocytes , and osteoclast differentiation supported by human bone marrow adipocytes . Regulation TNFSF11 TNF 22203215 2585898 The present data suggest that induces aberrant REG1a expression and that REG1a plays an important *role* in aberrant cell proliferation and [RANKL] expression of synovial fibroblasts , ultimately resulting in pannus formation . Regulation TNFSF11 TNF 22922824 2672504 Expression of OPG and [RANKL] was not *affected* by but modulated by trauma . Regulation TNFSF12 TNF 21211655 2374520 TWEAK upregulates TNF-a expression in primary keratinocytes , whereas did not *affect* the expression of [TWEAK] and its receptors . Regulation TNFSF13B TLR7 19201852 2033841 Although MDCs expressed higher levels of the known B cell growth factors IL-6 , IL-10 , and [B cell activating factor] in *response* to stimulation , they were unable to enhance B cell responses in this system . Regulation TNFSF13B TNF 17530706 1751415 These findings indicate that as neutrophils enter the site of inflammation , they release surface expressed [BLyS] in a *dependent* manner , and thus may contribute to local stimulation of autoimmune B cell responses . Regulation TNFSF13B TNF 22509979 2624700 Moreover , blockade did not appear to *affect* [BAFF] levels in either seropositive or seronegative RA patients , despite the association of anti-TNF treatment with the development of autoantibodies and the known anti-apoptotic effects of BAFF . Regulation TNFSF4 TNF 19220210 2105890 The aim of this study was to examine the *effect* of and interferon-gamma (IFN-gamma) on ASM CD40 and [OX40L] expression . Regulation TNIP3 TNF 18081698 1882956 Expression of the NF-kappaB inhibitor [ABIN-3] in *response* to and toll-like receptor 4 stimulation is itself regulated by NF-kappaB . Regulation TNKS EPHB2 22013039 2526986 We concluded that HSV targets [tankyrase 1] in an ICP0- and *dependent* manner to facilitate its replication . Regulation TNMD ITGB2 11261794 794542 The *role* of and VLA-4 in chemokine induced T cell [transendothelial migration (TEM)] across cytokine activated endothelium has not been examined . Regulation TNMD ITGB2 19307784 2052235 CD99 and , but not Gal , *play* a critical role in human monocyte and lymphocyte [TEM] across pEC , and their respective porcine ligands may serve as targets to specifically inhibit human leukocyte recruitment in pig-to-human xenotransplantation . Regulation TNNT2 CAPN1 16981728 1617092 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Regulation TNNT2 CAPN10 16981728 1617093 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Regulation TNNT2 CAPN11 16981728 1617094 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Regulation TNNT2 CAPN12 16981728 1617091 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Regulation TNNT2 CAPN13 16981728 1617102 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Regulation TNNT2 CAPN14 16981728 1617103 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Regulation TNNT2 CAPN15 16981728 1617090 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Regulation TNNT2 CAPN2 16981728 1617095 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Regulation TNNT2 CAPN3 16981728 1617096 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Regulation TNNT2 CAPN5 16981728 1617097 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Regulation TNNT2 CAPN6 16981728 1617098 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Regulation TNNT2 CAPN7 16981728 1617099 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Regulation TNNT2 CAPN8 16981728 1617100 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Regulation TNNT2 CAPN9 16981728 1617101 Supporting a *role* of in producing [cTnT-ND] in myocardial ischemia reperfusion , calpain inhibitors decreased the level of cTnT-ND in Triton extracted myofibrils . Regulation TNNT2 FGF23 22883134 2715709 LVMI and CAC were evaluated as potential mediators of the *effect* of on [hs-cTnI/T] . Regulation TNNT2 MYLIP 17408593 1728351 We have studied the *effect* of on the expression of various isoforms of [cardiac troponin T (cTnT)] , a component of the thin filament that binds with tropomyosin . Regulation TNNT2 NRG1 19801490 2164047 Inhibition of erbB2 , phosphoinositide 3-kinase (PI3K) , Akt , and mTOR blocked the protective *effects* of on cTnI and [cTnT] in NRVM . Regulation TNS1 EGF 12037131 949202 We studied whether and/or indomethacin ( IND ) *affect* cell migration , actin stress fiber formation , and/or phosphorylation of FAK and [tensin] in wounded gastric monolayers . Regulation TNS1 ILK 21719054 2460941 *regulates* phosphatase and [tensin] homologue activity to promote tumorigenesis in neuroblastoma cells . Regulation TNS1 PDK1 24039447 2842318 *plays* an essential role in regulating cell migration , especially in the context of phosphatase and [tensin] homologue deficiency . Regulation TNS1 SRC 7617039 315283 Regulation of cortactin and [tensin] hyperphosphorylation is *dependent* , whereas focal adhesion kinase and paxillin hyperphosphorylation is partly dependent on both Src and Fyn . Regulation TNS1 STAT3 20215508 2223331 Tumor derived cell lines displayed higher migration , invasion , and metastatic ability and showed disrupted distribution of cell-cell junction markers mediated by *dependent* overexpression of the COOH terminal [tensin-like] ( Cten ) focal adhesion protein , which was also significantly upregulated in Stat3C mammary tumors . Regulation TNS1 TNF 3131074 83446 Thus it appears that [TNS] contains another cytotoxic molecule and that itself may *act* indirectly in vivo , perhaps by activating an effector cell . Regulation TOB1 RORC 24307243 2921429 However , was not directly *involved* in the regulation of [Tob1] expression , whereas IL4I1 silencing in Th17 cells induced a substantial decrease of Tob1 expression . Regulation TOLLIP IL1B 16428431 1515888 [Tollip] therefore controls the magnitude of inflammatory cytokine production in *response* to and LPS . Regulation TOLLIP TLR7 16239509 1471042 We also determined that MyD88 , IRAK , TRAF6 , and [Toll interacting protein (Tollip)] , but not TIRAP , were involved in the mediated *response* to P. aeruginosa in HAECs . Regulation TP53 ABCG2 19107196 2004136 The present work demonstrated that protects ES cells from PPIX accumulation during colony expansion , and that [p53] and gammaH2AX *acts* as a downstream checkpoint of ABCG2 dependent defense machinery in order to maintain the self-renewal of ES cells . Regulation TP53 AXIN2 19731416 2134374 An axin mutation promotes carcinogenesis in Axin ( Fu ) /+ ( Axin Fused ) mice , consistent with a dominantnegative *role* for ( Fu ) in [p53] activation . Regulation TP53 EPHB2 15880691 1432968 Recent studies have shown that mediated signals *play* a major role in regulation of activity of [p53] tumor suppressor protein . Regulation TP53 EPHB2 16829532 1606411 Introduction of intracellular- or extracellular generated O2- during NO generation resulted in a concomitant increase in oxidative intermediates with a decrease in steady-state NO concentrations and a proportional reduction in the levels of sGC , , HIF-1alpha , and [p53] *regulation* . Regulation TP53 EPHB2 17117479 1677408 In addition , we provide evidence that the signaling *regulates* Cyclin dependent kinase 5 (Cdk5) activity and stability of [tumor suppressor p53] . Regulation TP53 EPHB2 17126425 1771528 may promote cell cycle arrest in prostate cells and this may be *regulated* by [p53] as restoration of wild-type p53 in p53 deficient prostate cancer cells results in their enhanced sensitivity to chemotherapeutic drugs and increased expression of Raf/MEK/ERK pathway . Regulation TP53 EPHB2 17624304 1775067 EGCG has been demonstrated to inhibit the growth of a variety of cancer cells , induce apoptosis and *regulate* the expression of [p53] , myc , and . Regulation TP53 FAS 10660538 664484 The functional conservation of p53 dependent Fas up-regulation argues strongly in favor of its biological importance and suggests that murine models may be used to study further the in vivo *role* of in the [p53] response . Regulation TP53 GPR115 19648965 2143301 *Regulation* of [p53] expression , phosphorylation and subcellular localization by a . Regulation TP53 GPR132 19648965 2143290 *Regulation* of [p53] expression , phosphorylation and subcellular localization by a . Regulation TP53 GPR87 19648965 2143370 *Regulation* of [p53] expression , phosphorylation and subcellular localization by a . Regulation TP53 ID1 19079342 2030885 negatively *regulated* both [p53] and PTEN at the transcriptional level . Regulation TP53 JAG1 24098521 2852276 *Regulation* of [p53] by contributes to angiotensin II-induced impairment of myocardial angiogenesis . Regulation TP53 MAP2K6 15880691 1432974 Recent studies have shown that mediated signals *play* a major role in regulation of activity of [p53] tumor suppressor protein . Regulation TP53 MAP2K6 17126425 1771534 may promote cell cycle arrest in prostate cells and this may be *regulated* by [p53] as restoration of wild-type p53 in p53 deficient prostate cancer cells results in their enhanced sensitivity to chemotherapeutic drugs and increased expression of Raf/MEK/ERK pathway . Regulation TP53 NMNAT2 24552824 2924487 Furthermore , knockdown of NMNAT-2 significantly reduces cellular NAD ( + ) levels and protects cells from p53 dependent cell death upon DNA damage , suggesting an important functional *role* of in [p53] mediated signaling . Regulation TP53 PADI3 18505818 1933874 Here , we report that 4 , a histone citrullination enzyme , is *involved* in the repression of [p53] target genes . Regulation TP53 PLAU 18836029 1993848 In addition , mediated signaling *controls* the expression of the tumor suppressor protein [p53] in lung epithelial cells at the posttranslational level . Regulation TP53 TFPI2 16598789 1604413 Together these results indicate that blockade is not *responsible* for OA-induced [p53] activation and G1 arrest in T51B cells . Regulation TP53 TNF 17567906 1763225 In *response* to , Zfra is upregulated and modulates TNF mediated cell death via interacting with TRADD , FADD and RIP ( death inducing signaling complex ) at the receptor level , and downstream effectors NF-kappaB , [p53] , WOX1 , and JNK1 . Regulation TP53 TNF 18065405 1882916 The relationship between [p53] status and *response* to and melphalan in patients undergoing ILP is unknown . Regulation TP53 TNF 20228833 2254451 We examined the effects of these mutations on interferon ( IFN ) induction , *response* , [p53] activity and apoptosis . Regulation TP53 TNFSF10 12917026 1130062 However , and doxorubicin did not *affect* [p53] and Bcl-2 protein expression . Regulation TP53 TP63 11423969 831104 We have found that and DeltaNp63alpha can differentially *regulate* endogenous [p53] target genes and induce cell cycle arrest and apoptosis . Regulation TP53 TP63 11423969 831105 Furthermore , the differential *regulation* of [p53] target genes by and DeltaNp63alpha suggests that p63 and p53 utilize both similar and different signaling pathways to execute their cellular functions . Regulation TP53 TP63 12446779 1017925 Based on this mechanism , we provide a model that explains the transactivation potential of homo- and heterotetramers composed of different isoforms and their *effect* on [p53] . Regulation TP53 TP63 18626511 1966564 Additionally , we observed a differential *effect* of mutants on wildtype-p63 mediated induction of [p53/p63] and p63 specific target genes . Regulation TP53I3 TP63 12374749 996674 Over expression of wild-type , but not deletion mutant , SSRP1 remarkably enhanced *dependent* luciferase activity , G1 arrest , apoptosis and expression of endogenous [PIG3] , p21 ( Waf1/cip1 ) and MDM2 in human p53-deficient lung carcinoma H1299 cells and mouse embryonic fibroblasts . Regulation TP63 ANXA6 8906830 394389 Pretreatment of IFN-gamma 0/0 mice with recombinant mouse IFN-gamma ( rIFN-gamma ) enhanced circulating TNF-alpha by as much as sixfold , but serum IL-12 [p40] and IL-12 *responses* increased by only twofold or less . Regulation TP63 BMP4 12013553 941619 is *involved* in [cusp] formation in molar tooth germ of mice . Regulation TP63 BMP4 12013553 941621 Our data thus suggest that is *involved* in [cusp] formation and differentiation of ameloblasts in the occlusal region of molars . Regulation TP63 CASP1 20001963 2204274 In the present study , we have demonstrated that Ets-1 [p51] , but not the spliced variant Ets-1 p42 , is processed in a *dependent* manner in Jurkat T-leukaemia cells undergoing apoptosis , resulting in three C-terminal fragments Cp20 , Cp17 and Cp14 and a N-terminal fragment , Np36 . Regulation TP63 CASP10 20001963 2204275 In the present study , we have demonstrated that Ets-1 [p51] , but not the spliced variant Ets-1 p42 , is processed in a *dependent* manner in Jurkat T-leukaemia cells undergoing apoptosis , resulting in three C-terminal fragments Cp20 , Cp17 and Cp14 and a N-terminal fragment , Np36 . Regulation TP63 CASP12 20001963 2204285 In the present study , we have demonstrated that Ets-1 [p51] , but not the spliced variant Ets-1 p42 , is processed in a *dependent* manner in Jurkat T-leukaemia cells undergoing apoptosis , resulting in three C-terminal fragments Cp20 , Cp17 and Cp14 and a N-terminal fragment , Np36 . Regulation TP63 CASP14 20001963 2204276 In the present study , we have demonstrated that Ets-1 [p51] , but not the spliced variant Ets-1 p42 , is processed in a *dependent* manner in Jurkat T-leukaemia cells undergoing apoptosis , resulting in three C-terminal fragments Cp20 , Cp17 and Cp14 and a N-terminal fragment , Np36 . Regulation TP63 CASP16 20001963 2204286 In the present study , we have demonstrated that Ets-1 [p51] , but not the spliced variant Ets-1 p42 , is processed in a *dependent* manner in Jurkat T-leukaemia cells undergoing apoptosis , resulting in three C-terminal fragments Cp20 , Cp17 and Cp14 and a N-terminal fragment , Np36 . Regulation TP63 CASP2 20001963 2204277 In the present study , we have demonstrated that Ets-1 [p51] , but not the spliced variant Ets-1 p42 , is processed in a *dependent* manner in Jurkat T-leukaemia cells undergoing apoptosis , resulting in three C-terminal fragments Cp20 , Cp17 and Cp14 and a N-terminal fragment , Np36 . Regulation TP63 CASP3 20001963 2204278 In the present study , we have demonstrated that Ets-1 [p51] , but not the spliced variant Ets-1 p42 , is processed in a *dependent* manner in Jurkat T-leukaemia cells undergoing apoptosis , resulting in three C-terminal fragments Cp20 , Cp17 and Cp14 and a N-terminal fragment , Np36 . Regulation TP63 CASP4 20001963 2204279 In the present study , we have demonstrated that Ets-1 [p51] , but not the spliced variant Ets-1 p42 , is processed in a *dependent* manner in Jurkat T-leukaemia cells undergoing apoptosis , resulting in three C-terminal fragments Cp20 , Cp17 and Cp14 and a N-terminal fragment , Np36 . Regulation TP63 CASP5 20001963 2204280 In the present study , we have demonstrated that Ets-1 [p51] , but not the spliced variant Ets-1 p42 , is processed in a *dependent* manner in Jurkat T-leukaemia cells undergoing apoptosis , resulting in three C-terminal fragments Cp20 , Cp17 and Cp14 and a N-terminal fragment , Np36 . Regulation TP63 CASP6 20001963 2204281 In the present study , we have demonstrated that Ets-1 [p51] , but not the spliced variant Ets-1 p42 , is processed in a *dependent* manner in Jurkat T-leukaemia cells undergoing apoptosis , resulting in three C-terminal fragments Cp20 , Cp17 and Cp14 and a N-terminal fragment , Np36 . Regulation TP63 CASP7 20001963 2204282 In the present study , we have demonstrated that Ets-1 [p51] , but not the spliced variant Ets-1 p42 , is processed in a *dependent* manner in Jurkat T-leukaemia cells undergoing apoptosis , resulting in three C-terminal fragments Cp20 , Cp17 and Cp14 and a N-terminal fragment , Np36 . Regulation TP63 CASP8 20001963 2204283 In the present study , we have demonstrated that Ets-1 [p51] , but not the spliced variant Ets-1 p42 , is processed in a *dependent* manner in Jurkat T-leukaemia cells undergoing apoptosis , resulting in three C-terminal fragments Cp20 , Cp17 and Cp14 and a N-terminal fragment , Np36 . Regulation TP63 CASP9 20001963 2204284 In the present study , we have demonstrated that Ets-1 [p51] , but not the spliced variant Ets-1 p42 , is processed in a *dependent* manner in Jurkat T-leukaemia cells undergoing apoptosis , resulting in three C-terminal fragments Cp20 , Cp17 and Cp14 and a N-terminal fragment , Np36 . Regulation TP63 CHUK 14960276 1208521 In Ikk alpha mutant mice and mice expressing a transdominant negative mutant of I kappa B alpha ( cI kappa B alpha Delta N ) , molars have abnormal cusps , indicating that is *involved* in [cusp] formation through the NF-kappa B pathway . Regulation TP63 CKAP4 15988020 1429258 Our results indicate that [p63] can *regulate* expression of specific target genes such as those involved in skin , limb , and craniofacial development by preferentially activating distinct response elements . Regulation TP63 DES 14998922 1220493 The inhibitory *effect* of was transient , and most cervicovaginal epithelial cells recovered expression of [p63] by 2 days after discontinuation of DES-treatment . Regulation TP63 DLX5 20808887 2314358 We show that [p63] binds to an enhancer element in the SHFM1 locus on chromosome 7q and that this element *controls* expression of DLX6 and possibly , both of which are important for limb development . Regulation TP63 DLX6 20808887 2314359 We show that [p63] binds to an enhancer element in the SHFM1 locus on chromosome 7q and that this element *controls* expression of and possibly DLX5 , both of which are important for limb development . Regulation TP63 ELN 8894984 392413 As a result , we believe that *plays* an important functional role in the [cusp] and that a full explanation of heart valve cusp mechanics must incorporate the contributions of both collagen and elastin . Regulation TP63 IFNB1 11331036 808330 *Regulation* by of inducible nitric oxide synthase and [interleukin-12/p40] in murine macrophages cultured in the presence of Chlamydia pneumoniae antigens . Regulation TP63 IL2 17234427 1664225 Human leukocyte antigen and , 10 and [12p40] cytokine *responses* to measles : is there evidence of the HLA effect ? Regulation TP63 ITCH 16908849 1608409 The E3 ubiquitin ligase *controls* the protein stability of [p63] . Regulation TP63 ITCH 16908849 1608412 Itch and p63 are coexpressed in the epidermis and in primary keratinocytes where *controls* the [p63] protein steady-state level . Regulation TP63 MAPK1 23250869 2741260 The findings reveal a tumor suppressive role of hsa-miR-196a2* through *regulation* of [TP63] by ERa and/or signaling . Regulation TP63 MDM2 11223036 787821 Moreover , ectopically expressed and MDMX could induce alterations in the subcellular localization of p73 , but did not *affect* the subcellular localization of p53 and [p63] . Regulation TP63 MDM2 11445003 834168 In this study , we examined the *effects* of and MdmX proteins on [p63] transactivation , apoptosis , and protein levels . Regulation TP63 NQO1 22249251 2681228 Previously , we have shown a *role* of cytosolic ( NQO1 ) in the stabilization of [p63] against 20S proteasomal degradation resulting in thinning of the epithelium and chemical induced skin cancer ( Oncogene ( 2011 ) 30 , 1098-1107 ) . Regulation TP63 PML 16007146 1465538 Here we present data indicating that ( i ) the physically interacts with p63 , ( ii ) p63 is localized into the PML nuclear-bodies (PML-NBs) in vivo , and ( iii ) PML *regulates* [p63] transcriptional activity . Regulation TP63 SATB1 21930775 2479641 [p63] *regulates* to control tissue-specific chromatin remodeling during development of the epidermis . Regulation TP63 SATB2 21965674 2507439 Interestingly , AEC but not EEC p63 mutations affect the ability of p63 to interact with SATB2 and the inhibitory *effects* of on [p63] transactivation of perp are most pronounced for AEC associated p63 mutations . Regulation TP63 SCGB1D4 23906066 2822513 Collectively , the present study reveals a critical role for *dependent* control of [p63] activity in coordination of ACD and stratification during epithelial morphogenesis . Regulation TP63 SEC14L2 16331262 1539513 *regulates* expression of [DeltaN-p63] in a manner that is sensitive to p53 . Regulation TP63 SWI5 8816483 384190 The transcription factor *regulates* expression of the cyclin kinase inhibitor [p40SIC1] . Regulation TP63 TUFM 16365417 1504916 The stimulatory *effect* of on the activation of [IL-12p40] promoter was mapped to a region harboring an NF-kappaB binding site . Regulation TP63 TWIST1 22411303 2582316 *plays* a role in molar development and [cusp] formation by participating in the reciprocal signaling needed for the formation of the enamel knot . Regulation TP63 USO1 18626511 1966562 In this report , we studied the *effects* of naturally occurring mutants on the regulation of [p53/p63] and p63 specific target genes . Regulation TPM1 EPHB2 17895359 1811272 We identified , for the first time , death associated protein kinase 1 ( DAP kinase 1 ) as the kinase that phosphorylates [tropomyosin-1] in *response* to activation by hydrogen peroxide ( H ( 2 ) O ( 2 ) ) . Regulation TPM1 TMOD1 11960785 932507 In conclusion 1 ) HSP27 phosphorylation appears to be necessary for reorganization of HSP27 inside the cell and seems to be directly correlated with the PKC signal transduction pathway , and 2 ) agonist induced phosphorylation of HSP27 modulates actin-myosin interaction through *regulation* of [tropomyosin] . Regulation TPM1 TMOD1 12419997 1013346 The phosphorylation of did not *affect* interaction with [tropomyosin] as measured by a gel overlay assay . Regulation TPM2 TMOD1 11960785 932510 In conclusion 1 ) HSP27 phosphorylation appears to be necessary for reorganization of HSP27 inside the cell and seems to be directly correlated with the PKC signal transduction pathway , and 2 ) agonist induced phosphorylation of HSP27 modulates actin-myosin interaction through *regulation* of [tropomyosin] . Regulation TPM2 TMOD1 12419997 1013350 The phosphorylation of did not *affect* interaction with [tropomyosin] as measured by a gel overlay assay . Regulation TPM3 TMOD1 11960785 932513 In conclusion 1 ) HSP27 phosphorylation appears to be necessary for reorganization of HSP27 inside the cell and seems to be directly correlated with the PKC signal transduction pathway , and 2 ) agonist induced phosphorylation of HSP27 modulates actin-myosin interaction through *regulation* of [tropomyosin] . Regulation TPM3 TMOD1 12419997 1013354 The phosphorylation of did not *affect* interaction with [tropomyosin] as measured by a gel overlay assay . Regulation TPM4 TMOD1 11960785 932516 In conclusion 1 ) HSP27 phosphorylation appears to be necessary for reorganization of HSP27 inside the cell and seems to be directly correlated with the PKC signal transduction pathway , and 2 ) agonist induced phosphorylation of HSP27 modulates actin-myosin interaction through *regulation* of [tropomyosin] . Regulation TPM4 TMOD1 12419997 1013358 The phosphorylation of did not *affect* interaction with [tropomyosin] as measured by a gel overlay assay . Regulation TPO TNF 7867596 296467 In the present study , we used FRTL5 cells , a cultured rat thyroid follicular cell line , to examine the *effects* of IFN-gamma and on type I 5'-deiodinase ( 5'D-I ) activity and 5'D-I , [thyroid peroxidase (TPO)] and thyroglobulin (Tg) gene expression . Regulation TPO TNF 7867596 296481 We also examined the *effect* of IFN-gamma and on [TPO] and Tg gene expression . Regulation TPO TNF 7867596 296483 As observed with 5'D-I mRNA levels , there was a synergistic *effect* of IFN-gamma and on the inhibition of basal and TSH stimulated [TPO] and Tg gene expression . Regulation TRAF4 TP63 18087216 1839983 We investigated the *involvement* of in regulation of [TRAF4] and the expression of the TRAF4 protein in SCCHN . Regulation TRAF6 SELL 11842086 929196 We show that HSP70 induces interleukin-12 (IL-12) and endothelial ( ELAM-1 ) promoters in macrophages and that this is *controlled* by MyD88 and [TRAF6] . Regulation TRAF6 TLR7 16239509 1471032 We also determined that MyD88 , IRAK , [TRAF6] , and Toll interacting protein (Tollip) , but not TIRAP , were involved in the mediated *response* to P. aeruginosa in HAECs . Regulation TREM1 TLR7 12646648 1070245 Expression of [TREM-1] was up-regulated in *response* to activation , an effect further enhanced by GM-CSF and TNF-alpha but inhibited by IL-10 . Regulation TREM1 TLR7 19904768 2189120 Although TLR ligands such as LPS and lipoteichoic acid have been shown to upregulate TREM-1 expression in macrophage and neutrophils , the *role* of specific in inducing the expression of [TREM-1] remains unclear . Regulation TREM1 TLR7 19904768 2189153 These data indicate that the expression of [TREM-1] in *response* to ligands occurs secondary to downstream signaling events and that the presence of TLR is necessary for the expression of TREM-1 in response to their specific ligands . Regulation TREM1 TNF 15611278 1357385 Intriguingly , in contrast to monocytes , intestinal macrophages fail to up-regulate [TREM-1] in *response* to . Regulation TREM1 TNF 22642593 2604725 Our finding that [TREM-1] *controls* the production of IL-8 and in U937 foam cells defines a potentially critical role of TREM-1 in the pathogenesis of atherosclerosis and implicates TREM-1 as a potential therapeutic target for the disease . Regulation TRIM26 LHX4 21965270 2507363 Using in silico analysis , the evolutionary conserved region within the AFP promoter containing LHX4 binding site was identified , implying that [AFP] is a putative *target* for . Regulation TRIM26 TCN1 20087354 2206049 Anti-AFP Th1 response was mainly detected in HCC patients who had normal or mildly elevated serum AFP concentrations ( P=0.00188 ) , whereas there was no significant difference between serum AFP concentrations in these patients and the presence of an [anti-AFP] *response* . Regulation TRIM26 TNF 2467770 107950 In both lines , crude cytokine preparations from LPS activated human monocytes ( CM ) and several cell lines led to increased PI and decreased AFP synthesis , while recombinant interleukin 1 (IL-1) , recombinant and hepatocyte stimulating factor preparations ( HSF ) *affected* [AFP] but not PI production . Regulation TRIM33 EPHB2 12824291 1113648 These results indicate that *dependent* [R-Smad] linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells . Regulation TRIM63 FBXO32 18616983 1947355 Taken together , these findings indicated that leucine , isoleucine and arginine decreased mRNA levels via mTOR and that different pathways were *involved* in the effect of those amino acids on [MuRF1] mRNA levels . Regulation TRIM63 FBXO32 24550841 2915488 MURF1 , and FBXO40 , their substrate targets PKM2 , myogenin , MYOD , MHC and EIF3F as well as [MURF1] and atrogin-1 transcriptional *regulators* FOXO1 and FOXO3 gene and/or protein expression levels were measured via real time PCR and western blotting , respectively . Regulation TRIM63 FOXO1 20079455 2218698 Results suggest that sepsis increases FOXO1 expression and activity in skeletal muscle by a glucocorticoid dependent mechanism and that glucocorticoid dependent upregulation of atrogin-1 and [MuRF1] in skeletal muscle is *regulated* by . Regulation TRPC1 EPHB2 23526217 2818729 Real-time quantitative PCR was used for the measurement of mRNA , Western blotting was used for the measurement of protein , and fluorescent microscopic for [ Ca ( 2+ ) ] i was used to determine the *involvement* of p38 and mitogen activated protein kinase (MAPK) signaling in BMP4 induced [TRPC] expression and the elevation of [ Ca ( 2+ ) ] i in PASMCs . Regulation TRPC1 GPR115 18323855 1897857 [TRPP2/TRPC1] is activated in *response* to activation and shows a pattern of single-channel conductance , amiloride sensitivity and ion permeability distinct from that of TRPP2 or TRPC1 alone . Regulation TRPC1 GPR132 18323855 1897846 [TRPP2/TRPC1] is activated in *response* to activation and shows a pattern of single-channel conductance , amiloride sensitivity and ion permeability distinct from that of TRPP2 or TRPC1 alone . Regulation TRPC1 GPR87 18323855 1897926 [TRPP2/TRPC1] is activated in *response* to activation and shows a pattern of single-channel conductance , amiloride sensitivity and ion permeability distinct from that of TRPP2 or TRPC1 alone . Regulation TRPC2 EPHB2 23526217 2818744 Real-time quantitative PCR was used for the measurement of mRNA , Western blotting was used for the measurement of protein , and fluorescent microscopic for [ Ca ( 2+ ) ] i was used to determine the *involvement* of p38 and mitogen activated protein kinase (MAPK) signaling in BMP4 induced [TRPC] expression and the elevation of [ Ca ( 2+ ) ] i in PASMCs . Regulation TRPC3 EPHB2 23526217 2818759 Real-time quantitative PCR was used for the measurement of mRNA , Western blotting was used for the measurement of protein , and fluorescent microscopic for [ Ca ( 2+ ) ] i was used to determine the *involvement* of p38 and mitogen activated protein kinase (MAPK) signaling in BMP4 induced [TRPC] expression and the elevation of [ Ca ( 2+ ) ] i in PASMCs . Regulation TRPC4 EPHB2 23526217 2818774 Real-time quantitative PCR was used for the measurement of mRNA , Western blotting was used for the measurement of protein , and fluorescent microscopic for [ Ca ( 2+ ) ] i was used to determine the *involvement* of p38 and mitogen activated protein kinase (MAPK) signaling in BMP4 induced [TRPC] expression and the elevation of [ Ca ( 2+ ) ] i in PASMCs . Regulation TRPC5 EPHB2 23526217 2818789 Real-time quantitative PCR was used for the measurement of mRNA , Western blotting was used for the measurement of protein , and fluorescent microscopic for [ Ca ( 2+ ) ] i was used to determine the *involvement* of p38 and mitogen activated protein kinase (MAPK) signaling in BMP4 induced [TRPC] expression and the elevation of [ Ca ( 2+ ) ] i in PASMCs . Regulation TRPC6 EPHB2 23526217 2818804 Real-time quantitative PCR was used for the measurement of mRNA , Western blotting was used for the measurement of protein , and fluorescent microscopic for [ Ca ( 2+ ) ] i was used to determine the *involvement* of p38 and mitogen activated protein kinase (MAPK) signaling in BMP4 induced [TRPC] expression and the elevation of [ Ca ( 2+ ) ] i in PASMCs . Regulation TRPC6 EPHB2 23875811 2854492 [TRPC6] channel mediated neurite outgrowth in PC12 cells and hippocampal neurons *involves* activation of , PI3K , and CAMKIV signaling . Regulation TRPC6 MAP2K6 23875811 2854500 [TRPC6] channel mediated neurite outgrowth in PC12 cells and hippocampal neurons *involves* activation of , PI3K , and CAMKIV signaling . Regulation TRPC7 EPHB2 23526217 2818819 Real-time quantitative PCR was used for the measurement of mRNA , Western blotting was used for the measurement of protein , and fluorescent microscopic for [ Ca ( 2+ ) ] i was used to determine the *involvement* of p38 and mitogen activated protein kinase (MAPK) signaling in BMP4 induced [TRPC] expression and the elevation of [ Ca ( 2+ ) ] i in PASMCs . Regulation TRPM6 TLR7 16547253 1537714 [HSH2] expression is increased in *response* to anti-CD40 mAb , the ligands LPS and CpG DNA , and B lymphocyte stimulator (BLyS) , a key regulator of peripheral B cell survival and homeostasis . Regulation TRPM7 CAPN8 16436382 1547585 [TRPM7] *regulates* cell adhesion by controlling the calcium dependent protease . Regulation TRPV1 ARSA 24495935 2923713 We now studied the *effect* of on heterologously expressed rat [TRPV1] using calcium microfluorimetry . Regulation TRPV1 EPHB2 17851089 1817833 Furthermore , we found that activation of but not of p38 kinase or cyclooxygenases is critically *involved* in the TNFalpha induced increase of [TRPV1] receptor expression . Regulation TRPV1 MAP2K6 18034335 1924437 In summary , the activation of [TRPV1] by capsaicin modulates the SP release from DRG neurons via two different mechanisms , one requiring extracellular Ca2+ , the activation of PI3K and the IP3 dependent intracellular Ca2+ release , and the other which is independent of extracellular Ca2+ but *involves* the activation of . Regulation TRPV1 TNF 16200599 1463844 The possibility that exogenous was *involved* in influencing [TRPV1] activation was investigated in separate experiments . Regulation TRPV2 EPHB2 20093382 2248381 Overall , our findings indicate that [TRPV2] negatively controls glioma cell survival and proliferation , as well as resistance to Fas induced apoptotic cell death in an *dependent* manner . Regulation TRPV5 ABCA4 21328349 2480354 Detection of TRPV5 by PCR and immunohistochemistry and the sensitivity of the RMP to the TRPV5 inhibitor econazole ( ?V ( m ) = -18 ± 3 mV ) suggests that the may be , in part , *controlled* by [TRPV5] . Regulation TRPV6 RGS2 16895908 1625733 Furthermore , cell surface biotinylation indicated that the inhibitory *effect* of on [TRPV6] activity is not mediated by differences in trafficking or retrieval of TRPV6 from the plasma membrane . Regulation TRPV6 RGS2 16895908 1625735 Finally , the scaffolding protein spinophilin , shown to recruit RGS2 and regulate GPCR signaling via G ( alpha ) , did not affect RGS2 binding and electrophysiological properties of TRPV6 , indicating a GPCR independent mechanism of [TRPV6] *regulation* by . Regulation TSC1 CAPN8 23467348 2750017 BDNF treatment rapidly reduced levels of [hamartin] and tuberin , negative regulators of mTOR , in a *dependent* manner . Regulation TSC1 EPHB2 15757502 1409723 Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of and *involves* phosphorylation of [tuberous sclerosis complex 2 (TSC2)] . Regulation TSC2 EPHB2 17510244 1766847 These results demonstrate the *involvement* of rather than Akt in FSH mediated [TSC2] phosphorylation in granulosa cells . Regulation TSHB IL1B 7623615 315927 *Effect* of , tumour necrosis factor-alpha and interleukin-6 on the control of [thyrotropin] secretion . Regulation TSHB IL1B 8612490 353127 *Effects* of on [thyrotropin] secretion and thyroid hormone uptake in cultured rat anterior pituitary cells . Regulation TSHB TNF 7479297 331848 We examined the chronic ( 72 h ) *effects* of 30 ng/ml recombinant murine on release of immunoreactive growth hormone (GH) , prolactin (PRL) , [thyrotropin] ( TSH ) , and TSH glycosylation , as assessed by lectin binding , in cultured rat anterior pituitary cells . Regulation TSHR RGS2 15362969 1293884 Furthermore , the *effects* of expression on [TSHR] signaling ( cAMP- , inositol-3-phosphate accumulation , TSHR cell surface expression ) were studied in COS-7 cells . Regulation TSLP TLR7 18084696 1834616 This study investigated whether ligands , lipopolysaccharide (LPS) and poly-IC *affect* [TSLP] production in synovial fibroblasts . Regulation TSLP TLR7 21690322 2455650 DCs are important primary targets of TSLP , and we unexpectedly demonstrated that DCs also produce [TSLP] in *response* to stimulation and that this is augmented by IL-4 . Regulation TSPAN1 CD81 15004227 1237063 Dynamic regulation of a [GPCR-tetraspanin-G] protein complex on intact cells : central *role* of in facilitating GPR56-Galpha q/11 association . Regulation TSPAN12 FZD4 19837033 2155011 [TSPAN12] *regulates* retinal vascular development by promoting Norrin- but not Wnt induced signaling . Regulation TTN TNF 20373002 2282037 Further , we examined the *effect* of on myocardial expression of [titin] and dystrophin in vitro in rat cardiac myoblast cell line ( H9c2 ) . Regulation TTR CLU 21224044 2379375 Taken together , these results suggest that may *play* a pathogenetic role in [TTR] and Ig light chain amyloidoses and amyloidotic CMP . Regulation TTR F2R 17102904 1709094 In addition , direct activation of PAR-2 by hexapeptide SLIGKV increased P(alb) comparable to MCC , whereas activation by TFLLRN had no *effect* on [P(alb)] . Regulation TTR TF 12644233 1069630 *dependent* expression of [TbpA] by Histophilus ovis involves a poly G tract within tbpA . Regulation TTR TF 12644233 1069632 A poly G tract in tbpA of Histophilus ovis strain 3384Y was suspected of being responsible for the *dependent* expression of [TbpA] . Regulation TUB IGF1 10455176 638607 Here we demonstrate that in CHO-IR cells , transfected [Tub] is phosphorylated on tyrosine in *response* to insulin and and that in PC12 cells , insulin but not EGF induced tyrosine phosphorylation of endogenous Tub . Regulation TUB INS 10455176 638608 Here we demonstrate that in CHO-IR cells , transfected [Tub] is phosphorylated on tyrosine in *response* to and insulin-like growth factor-1 and that in PC12 cells , insulin but not EGF induced tyrosine phosphorylation of endogenous Tub . Regulation TUB SFTPB 9130700 426921 Previously , we have shown that the gamma-tubulin [Tub4p] and the spindle pole body component Spc98p are *involved* in microtubule organization by the yeast microtubule organizing centre , the . Regulation TUBGCP4 AXIN2 19390532 2089378 These results suggest that , but not Axin2 , is *involved* in microtubule nucleation by forming a complex with [gamma-tubulin] at the centrosome . Regulation TUBGCP5 AXIN2 19390532 2089382 These results suggest that Axin , but not , is *involved* in microtubule nucleation by forming a complex with [gamma-tubulin] at the centrosome . Regulation TUBGCP6 AXIN2 19390532 2089380 These results suggest that , but not Axin2 , is *involved* in microtubule nucleation by forming a complex with [gamma-tubulin] at the centrosome . Regulation TUFM MUC16 23663754 2810889 The expression of adhesin [EF-Tu] in *response* to and its role in Lactobacillus adhesion and competitive inhibition of enteropathogens to mucin . Regulation TXN TNF 10555039 565799 The *effect* of oxidative stress and on [TRX] expression by cultured rheumatoid fibroblast-like synoviocytes was studied . Regulation TXN TNF 21636804 2454897 Thioredoxin interacting protein mediates [TRX1] translocation to the plasma membrane in *response* to : a key mechanism for vascular endothelial growth factor receptor-2 transactivation by reactive oxygen species . Regulation TXNIP EPHB2 21771725 2484485 These data indicate that [TXNIP] negatively *regulates* bladder carcinogenesis by attenuating SDF-1-CXCR4 induced activation . Regulation TXNIP TNF 20826751 2325239 These results indicate that [VDUP1] negatively *regulates* hepatocarcinogenesis by suppressing induced NF-?B activation . Regulation TYMP TNFSF10 11750847 898149 However , the expression level of [thymidine phosphorylase (TP)] was not *affected* by . Regulation TYR CAPN8 16335789 1491281 These results indicate that would be *involved* in the melanogenic signaling by modulating the expression of [tyrosinase] in mouse B16 melanoma cells . Regulation TYR EFNB1 17310244 1699570 Phosphorylation of [Tyr392] and the recruitment of GIT1 to synapses are *regulated* by activation . Regulation TYR PLAT 20724593 2323794 The mitogenic *effect* of required [Tyr] ( 4507 ) phosphorylation of the cytoplasmic tail of its receptor LDL receptor related protein 1 . Regulation TYR TNF 10102625 602283 Furthermore , a mutant of inhibitory kappa B ( IkappaB ) , that prevents NFkappaB activation , is able to revert the *effect* of on the [tyrosinase] promoter activity . Regulation TYR TNF 9692912 523283 Therefore , the inhibitory *effect* of on [tyrosinase] and TRP-1 results from combined effect on mRNA levels and enzymatic activity or protein stability . Regulation TYRO3 FOLR1 24186951 2890216 It showed that in addition to aox , , and pck , RSE2 and [RSE3] *regulate* the expression of genes encoding the alternative NADH dehydrogenase , a Zn2Cys6 transcription factor , a flavohemoglobin , and various hydrolases . Regulation TYRP1 MAP2K6 12606410 1064537 The nitric oxide mediated increase of [P-Thr-Glu-Tyr-P] *involved* protein Tyr kinase , or MEK-like kinase , and protein kinase C but not protein kinase A . Regulation TYRP1 TNF 9692912 523284 Therefore , the inhibitory *effect* of on tyrosinase and [TRP-1] results from combined effect on mRNA levels and enzymatic activity or protein stability . Regulation UBA7 G0S2 23546556 2767140 Intriguingly , transfection of did not *affect* endogenous RARß , [UBE1L] or G0S2 expression . Regulation UBE2G2 AGR2 23942235 2840871 Structural analysis of the RING : Ube2g2 : G2BR complex reveals that induced conformational *effect* at the RING : Ube2g2 interface is necessary for enhanced binding of RING to [Ube2g2] or Ube2g2 conjugated to Ub . Regulation UCA1 PTBP1 24457952 2907482 Of interest , the phosphorylated form of , predominantly in the cytoplasm , is *responsible* for the interaction with [UCA1] . Regulation UCA1 SETD2 24737584 2943108 The *effect* of inhibition by YC-1 on [lncRNA-UCA1] expression was also examined . Regulation UCN2 EPHB2 17218420 1709709 In addition , [Ucn 2-stimulated] cAMP and *responses* were blocked by the CRF2 antagonist , astressin2-B . Regulation UCP1 IL1B 17164436 1716987 Brown fat [UCP1] is not involved in the febrile and thermogenic *responses* to in mice . Regulation UCP1 IL1B 17164436 1716988 In support of this , we found no *effect* of on triglyceride content and [UCP1] mRNA level in BAT , in contrast with apparent effects of CL316,243 . Regulation UCP1 PGC 11875072 936964 As in rodents , is *involved* in the transcriptional regulation of the [UCP1] gene in humans and mediates the effects of PPARalpha and PPARgamma agonists and retinoic acid . Regulation UCP1 PGC 21103377 2350404 Gene expression of , a *regulator* of fatty acid oxidation and [Ucp1] , a brown adipocyte specific protein , was increased in the white adipose tissue of the transgenic mice . Regulation UCP1 PGC 23717545 2793043 The aim of the present study was to test the hypotheses that 1 ) a single exercise bout increases UCP1 mRNA in both inguinal ( i ) WAT and epididymal ( e ) WAT , 2 ) UCP1 expression and responsiveness to exercise are different in iWAT and eWAT , 3 ) PGC-1a determines the basal levels of UCP1 and PRDM16 in WAT and 4 ) exercise and exercise training regulate [UCP1] and PRDM16 expression in WAT in a *dependent* manner . Regulation UCP1 TNF 11277995 798119 MEK inhibition with PD98059 abolished the inhibitory *effect* of on [UCP-1] , but not on adipogenic genes . Regulation UCP1 TNF 12044870 949903 Differential role of PPAR gamma in the *regulation* of [UCP-1] and adipogenesis by in brown adipocytes . Regulation UCP1 TNF 12044870 949905 Extracellular regulated kinases ( ERKs ) mediate the inhibitory *effect* of on [uncoupling protein-1 (UCP-1)] , but not on lipid accumulation . Regulation UCP1 TNF 12044870 949906 Thus , the negative *effect* of on [UCP-1] mRNA expression at 4-5 h , under basal conditions or in cells treated with the PPAR gamma agonist , rosiglitazone , was reversed by the MEK1 inhibitor PD98059 . Regulation UCP1 TNF 9989288 596993 To evaluate the interaction of TNF-alpha with UCPs in thermogenesis , *effects* of on rat [UCP] gene expression were examined in intrascapular brown adipose tissue (BAT) , epididymal white adipose tissue ( WAT ) and soleus muscle ( Muscle ) . Regulation UCP2 FOXA1 23625627 2887249 These data indicate an important *role* of in regulating expression of [UCP2] . Regulation UCP2 TNF 10092993 601020 To investigate functional modulators of uncoupling protein-2 (UCP2) gene expression , we examined the *effects* of on [UCP2] mRNA expression in rats . Regulation UCP2 TNF 11003590 734693 The characterization of the mechanisms responsible for the *effect* on [UCP-2] expression demonstrates an involvement of the TNF-alpha induced inducible ( i ) nitric oxide synthase (NOS) expression . Regulation UCP2 TNF 11003590 734694 Cell treatment with the NOS inhibitor N ( G ) -nitro-L-arginine methyl ester ( L-NAME ; 1 mmol/l ) significantly diminished the TNF-alpha mediated sustained downregulation of UCP-2 expression , whereas cell treatment with a nitric oxide ( NO ) donor ( 10 ( -3 ) mol/l S-nitroso-L-glutathione ) mimicked the *effect* on [UCP-2] expression . Regulation UGCG IL1B 8662965 367737 In summary , the expression of [gamma-GCS] is *regulated* by TNF-alpha or in endothelial cells mediated by NF-kappaB stimulation , and impairment of the regulation of gamma-GCS in hyperglycemic cells may be a cause of medical complications that develop in diabetes mellitus . Regulation UGCG JAG1 22529295 2602555 One widely cited model posits that long lived plasma cells derive from [germinal centers (GCs)] in *response* to T cell dependent ( TD ) . Regulation UGCG TNF 15257546 1272353 We investigated the *regulation* of [gamma-GCS] by transforming growth factor beta(1) ( TGF-beta(1) ) and in human lung cells and its expression and distribution in fibrotic ( biopsy-proven idiopathic pulmonary fibrosis , for instance , usual interstitial pneumonia , UIP , n = 15 ) , inflammatory , and granulomatous diseases of human lung parenchyma ( desquamative interstitial pneumonia , n = 10 ; Regulation UGCG TNF 8662965 367733 The addition of inhibitors for nuclear factor kappaB (NF-kappaB) to the cells caused a loss of the [gamma-GCS] mRNA expression in *response* to . Regulation UGCG TNF 8662965 367736 In summary , the expression of [gamma-GCS] is *regulated* by or IL-1beta in endothelial cells mediated by NF-kappaB stimulation , and impairment of the regulation of gamma-GCS in hyperglycemic cells may be a cause of medical complications that develop in diabetes mellitus . Regulation UGGT2 FOXA1 20736324 2345815 We recently reported that *regulates* the basal expression of the [UGT2B17] gene in prostate cancer cells . Regulation UGGT2 FOXA1 20736324 2345822 Because local inactivation of active androgens by UGT2B15 and UGT2B17 has been shown to be a major determinant of androgen response and signaling activity , *regulation* of the UGT2B15 and [UGT2B17] genes by may have an important role in the maintenance of androgen homeostasis within prostate cancer cells . Regulation UGT1A6 ABCC1 12110372 963290 Coordinate *regulation* of UDP-glucuronosyltransferase [UGT1A6] induction by 3-methylcholanthrene and multidrug resistance protein expression by dexamethasone in primary rat hepatocytes . Regulation UGT1A6 ASIP 10049505 592640 The *role* of in [UGT1A6] was investigated by comparing some properties of UGT mutant proteins that have a single mutation ( D446K , D446E , D446N , D446Q , D446A , and D446T ) . Regulation UGT1A6 HNF1A 16399343 1494610 may be *responsible* for tissue-specific [UGT1A6] expression . Regulation UGT1A6 PRKCD 20196639 2237016 *Role* for in the functional activity of human [UGT1A6] : implications for drug-drug interactions between PKC inhibitors and UGT1A6 . Regulation UGT1A7 HNF1A 20406851 2274176 Shared *regulation* of [UGT1A7] by and HNF4alpha . Regulation UGT1A7 HNF4A 20406851 2274177 Shared *regulation* of [UGT1A7] by hepatocyte nuclear factor (HNF) 1alpha and . Regulation UGT2B15 FOXA1 20736324 2345812 *regulates* [UDP-glucuronosyltransferase 2B15] gene transcription in LNCaP prostate cancer cells . Regulation UGT2B15 FOXA1 20736324 2345818 In this study , we show that also *regulates* basal expression of the [UGT2B15] gene in the prostate cell line LNCaP ( lymph node carcinoma of the prostate ) . Regulation UGT2B15 FOXA1 20736324 2345820 Silencing of FOXA1 expression by small interfering RNA significantly reduced UGT2B15 transcript levels , further confirming a crucial *role* of in controlling [UGT2B15] gene expression . Regulation UGT2B15 FOXA1 20736324 2345821 Because local inactivation of active androgens by UGT2B15 and UGT2B17 has been shown to be a major determinant of androgen response and signaling activity , *regulation* of the [UGT2B15] and UGT2B17 genes by may have an important role in the maintenance of androgen homeostasis within prostate cancer cells . Regulation UMOD HSD11B2 8969942 402768 These results show that both 3 [alpha,5B-THP] and CDCA are hypertensinogenic in the rat and that the inhibition of either <11 beta-HSD2> or 11 beta-HSD1 activity by endogenous progesterone metabolites and CDCA may be *involved* in the pathology of hypertension . Regulation UMOD IL1B 19697035 2258169 The level of IL-6 expression was strongly increased in both FLSs and [THP-1] macrophages in *response* to and TNF-alpha , but the level by TNF-alpha was less than that by IL-1beta . Regulation UMOD TNF 18303186 1873573 *Role* of and extracellular ATP in [THP-1] cell activation following allergen exposure . Regulation UMOD TNF 18303186 1873574 Therefore , in this study , we investigated the *effect* of and extracellular ATP on [THP-1] cell activation induced by chemical allergens . Regulation UMOD TNF 19697035 2258168 The level of IL-6 expression was strongly increased in both FLSs and [THP-1] macrophages in *response* to IL-1beta and , but the level by TNF-alpha was less than that by IL-1beta . Regulation UNC13A TNF 21805469 2495253 Taken together , these findings demonstrate that Rab37 interacts with [Munc13-1] to *control* secretion from activated macrophages . Regulation UNC5B AGAP2 21460185 2433216 Depletion of Akt abrogates 's inhibitory *effect* on both p53 and [UNC5B] . Regulation UNC5B AKT1 21460185 2433205 Here we show that phosphorylates PIKE-A and *regulates* its association with [UNC5B] and inhibits UNC5B provoked apoptosis in a p53 dependent manner . Regulation UNC5B AKT2 21460185 2433206 Here we show that phosphorylates PIKE-A and *regulates* its association with [UNC5B] and inhibits UNC5B provoked apoptosis in a p53 dependent manner . Regulation UNC5B AKT3 21460185 2433207 Here we show that phosphorylates PIKE-A and *regulates* its association with [UNC5B] and inhibits UNC5B provoked apoptosis in a p53 dependent manner . Regulation UNC5B TCF12 23599441 2783833 These responses are abrogated by inhibiting hypoxia-inducible transcription factor ( HIF)-1a , indicating a causal *role* for this in regulating Ntn1 and [Unc5b] expression in macrophages . Regulation UNC5B TCF15 23599441 2783834 These responses are abrogated by inhibiting hypoxia-inducible transcription factor ( HIF)-1a , indicating a causal *role* for this in regulating Ntn1 and [Unc5b] expression in macrophages . Regulation UNC5B TCF19 23599441 2783835 These responses are abrogated by inhibiting hypoxia-inducible transcription factor ( HIF)-1a , indicating a causal *role* for this in regulating Ntn1 and [Unc5b] expression in macrophages . Regulation UNC5B TCF20 23599441 2783836 These responses are abrogated by inhibiting hypoxia-inducible transcription factor ( HIF)-1a , indicating a causal *role* for this in regulating Ntn1 and [Unc5b] expression in macrophages . Regulation UNC5B TCF21 23599441 2783837 These responses are abrogated by inhibiting hypoxia-inducible transcription factor ( HIF)-1a , indicating a causal *role* for this in regulating Ntn1 and [Unc5b] expression in macrophages . Regulation UNC5B TCF23 23599441 2783841 These responses are abrogated by inhibiting hypoxia-inducible transcription factor ( HIF)-1a , indicating a causal *role* for this in regulating Ntn1 and [Unc5b] expression in macrophages . Regulation UNC5B TCF24 23599441 2783843 These responses are abrogated by inhibiting hypoxia-inducible transcription factor ( HIF)-1a , indicating a causal *role* for this in regulating Ntn1 and [Unc5b] expression in macrophages . Regulation UNC5B TCF25 23599441 2783842 These responses are abrogated by inhibiting hypoxia-inducible transcription factor ( HIF)-1a , indicating a causal *role* for this in regulating Ntn1 and [Unc5b] expression in macrophages . Regulation UNC5B TCF3 23599441 2783838 These responses are abrogated by inhibiting hypoxia-inducible transcription factor ( HIF)-1a , indicating a causal *role* for this in regulating Ntn1 and [Unc5b] expression in macrophages . Regulation UNC5B TCF4 23599441 2783839 These responses are abrogated by inhibiting hypoxia-inducible transcription factor ( HIF)-1a , indicating a causal *role* for this in regulating Ntn1 and [Unc5b] expression in macrophages . Regulation UNC5B TCF7 23599441 2783840 These responses are abrogated by inhibiting hypoxia-inducible transcription factor ( HIF)-1a , indicating a causal *role* for this in regulating Ntn1 and [Unc5b] expression in macrophages . Regulation UNC5B TP53 15818407 1425087 The expression of the axon-guidance molecule [UNC5B] ( also designated p53RDL1 ) , which is a receptor for netrin-1 , is directly *regulated* by . Regulation UNC93B1 TLR7 21683627 2455509 Thus , [Unc93B1] *controls* homeostatic activation by balancing TLR9 to TLR7 trafficking . Regulation USP11 TNF 17897950 1823993 The deubiquitinating enzyme [USP11] controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in *response* to . Regulation USP47 TNF 19966869 2217396 However , unlike canonical beta-Trcp substrates , [USP47] protein levels were neither *affected* by silencing of beta-Trcp nor modulated in a variety of processes , such as cell-cycle progression , DNA damage checkpoint responses or pathway activation . Regulation VAV1 CD22 12421939 1013713 In contrast , negatively *regulates* [Vav] phosphorylation . Regulation VAV1 CD22 9371816 466183 Thus , the differential *regulation* of [Vav] tyrosine phosphorylation by CD19 and may provide a molecular mechanism for adjusting BCR signaling thresholds . Regulation VCAM1 ALOX5 9120300 423850 In this study , we examined the *effects* of <5-lipoxygenase> inhibitors ( nordihydroguaiaretic acid and AA861 ) on IL-1 beta induced [VCAM-1] gene expression in HUVECs . Regulation VCAM1 ANGPT1 11557733 861442 In the present study , we used human umbilical vascular endothelial cells ( HUVECs ) to examine the *effect* of on VEGF induced expression of three adhesion molecules : intercellular adhesion molecule-1 ( ICAM-1 ) , [vascular cell adhesion molecule-1] ( VCAM-1 ) , and E-selectin . Regulation VCAM1 ANGPT1 19106103 2036488 Furthermore , depletion of KLF2 resulted in the loss of the inhibitory *effect* of on vascular endothelial growth factor ( VEGF ) -mediated expression of [vascular cell adhesion molecule-1] in endothelial cells and VEGF mediated monocyte adhesion to endothelial cells . Regulation VCAM1 EPHB2 15001568 1236973 The inhibitory effect of angiotensin II on iNOS expression was associated with a down-regulation of the sustained activation of extracellular signal regulated kinase ( ERK ) and NF-kappaB by interleukin-1beta , whereas the effect on [VCAM-1] was *independent* of activation . Regulation VCAM1 HES2 16247329 1471578 The *effect* of on endothelial cell surface expression of E-selectin , P-selectin , [vascular cell adhesion molecule-1] ( VCAM-1 ) , and intracellular adhesion molecule-1 ( ICAM-1 ) was evaluated by enzyme linked immunoabsorbant assay . Regulation VCAM1 HES2 16247329 1471634 After stimulation with IL-1 ( 10 U/mL ) , had no *effect* on the expression of P-selectin , E-selectin , ICAM-1 , or [VCAM-1] . Regulation VCAM1 IL1B 10233853 611730 Fibroblast-like synoviocytes rapidly up-regulate [VCAM-1] expression in *response* to and TNF-alpha , but also to IL-4 . Regulation VCAM1 IL1B 11748220 905529 Antisense oligonucleotide suppression of zfm1 protein synthesis mimicked the stimulatory *effects* of and TNF alpha on SMC proliferation and expression of the chemokine MCP-1 and the [vascular cell adhesion molecule-1] . Regulation VCAM1 IL1B 9500526 490803 Utilizing neutralizing antibodies , we show that CD40L mediated tissue factor and thrombomodulin modulation , as well as E-selectin and [VCAM-1] upregulation , is *independent* of tumor necrosis factor alpha , interleukin-1alpha , or production . Regulation VCAM1 ITGAL 11485925 844919 These results indicate that endothelial/lymphocyte adhesion cascades involving [VCAM-1/alpha(4)beta(1)] integrin , PNAd/L-selectin , and *control* the migration of lymphocytes into inflamed lacrimal gland . Regulation VCAM1 JAG1 7527450 280735 We investigated the effects of mAbs against [VCAM-1] and VLA-4 on cardiac allograft survival and humoral *response* to soluble . Regulation VCAM1 MMP28 12789230 1097233 An aim of this study was to evaluate the *effect* of inhibitors on the expression of ICAM-1 and [VCAM-1] in the migration of inflammatory cells in a murine model of TDI induced asthma . Regulation VCAM1 MMP28 12789230 1097277 We used a murine model to investigate TDI induced asthma to examine the possible involvement of ICAM-1 and VCAM-1 in the pathogenesis of that disease and the *effect* of inhibitors on the expression of ICAM-1 and [VCAM-1] . Regulation VCAM1 MMP7 12789230 1097248 An aim of this study was to evaluate the *effect* of inhibitors on the expression of ICAM-1 and [VCAM-1] in the migration of inflammatory cells in a murine model of TDI induced asthma . Regulation VCAM1 MMP7 12789230 1097293 We used a murine model to investigate TDI induced asthma to examine the possible involvement of ICAM-1 and VCAM-1 in the pathogenesis of that disease and the *effect* of inhibitors on the expression of ICAM-1 and [VCAM-1] . Regulation VCAM1 SPHK1 15191888 1295219 We further investigated the *role* of in TNF-alpha induced expression of inflammatory genes , such as monocyte chemoattractant protein-1 ( MCP-1 ) and [VCAM-1] by using small interfering RNA ( siRNA ) specifically for SphK1 . Regulation VCAM1 TNF 10233853 611729 Fibroblast-like synoviocytes rapidly up-regulate [VCAM-1] expression in *response* to IL-1beta and , but also to IL-4 . Regulation VCAM1 TNF 10638837 576815 Significant differences were found in the ability to respond to cytokines between HUVEC and the cell lines , the greatest differences being induction of [VCAM-1] and E-selectin in *response* to and induction of MHC class II antigens in response to IFN-gamma . Regulation VCAM1 TNF 10734000 678599 We therefore investigated the *role* of in the expression and release of [vascular cell adhesion molecule-1] ( VCAM-1 ) in cultures of human cerebral endothelial cells ( HCEC ) in comparison with peripheral blood mononuclear cells ( PBMC ) . Regulation VCAM1 TNF 11225735 580991 NF-kappaB activation was greatly potentiated by increased 15-LO activity in the stably transduced cells , and both [VCAM-1] and ICAM-1 were significantly induced in these cells in *response* to and phorbol 12-myristate 13-acetate ( PMA ) stimulation , as studied by flow cytometry . Regulation VCAM1 TNF 11687945 876007 The enhanced expression of [VCAM-1] is *independent* of systemic levels of and IL-1alpha , but may be the result of melanoma induced alterations at the local level , as we found evidence of melanoma cell occupation in heart , brain , and liver in pulmonary metastases bearing mice . Regulation VCAM1 TNF 11748220 905528 Antisense oligonucleotide suppression of zfm1 protein synthesis mimicked the stimulatory *effects* of IL-1 beta and on SMC proliferation and expression of the chemokine MCP-1 and the [vascular cell adhesion molecule-1] . Regulation VCAM1 TNF 12847490 1109001 In addition , the *effect* of on endothelial-leukocyte adhesion molecule 1 and [vascular cell adhesion molecule 1] expression by means of Western blot analysis was compatible with the mRNA results . Regulation VCAM1 TNF 1374588 186320 In contrast , dermal fibroblasts upregulated intercellular adhesion molecule-1 ( ICAM-1 ) but not [VCAM-1] expression in *response* to . Regulation VCAM1 TNF 14565715 1154956 HPVEC express E-selectin , ICAM-1 , and [VCAM-1] in *response* to the inflammatory cytokine similarly to other types of cultured human endothelial cells . Regulation VCAM1 TNF 14583404 1158919 In *response* to , isolated mouse brain endothelial cells ( MBEC ) express [vascular cell adhesion molecule-1] ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ) . Regulation VCAM1 TNF 14978108 1213431 The increase in intrahepatic NK cells depended on KCs and the *dependent* up-regulation of the adhesion molecule [VCAM-1] in the liver , but not on NKT cells . Regulation VCAM1 TNF 15158369 1252591 In ECV304 cells overexpressing ERalpha , E ( 2 ) significantly inhibited the *effects* of on NF-kappaB activation , [VCAM-1] expression , and U937 cell adhesion . Regulation VCAM1 TNF 16288471 1509658 Transcriptional *regulation* of [VCAM-1] expression by in human tracheal smooth muscle cells : involvement of MAPKs , NF-kappaB , p300 , and histone acetylation . Regulation VCAM1 TNF 16934424 1724328 Lung and synovial fibroblasts produce [VCAM-1] in *response* to . Regulation VCAM1 TNF 18602074 1935553 It also inhibited phosphorylation of Akt and PKC , which are upstream in the *regulation* of [VCAM-1] by . Regulation VCAM1 TNF 19136606 2042720 In the cells cultured under a low-glucose condition when no increased HBP flux occurred , azaserine enhanced the manganese-superoxide dismutase ( MnSOD ) protein level and also inhibited the oxidative stress and the expression of [VCAM-1] and ICAM-1 in *response* to . Regulation VCAM1 TNF 19238330 2093607 The cells showed constitutive activation as evidenced by the induction of basal VCAM-1 expression , and further showed a more augmented [VCAM-1] and E selectin *response* to compared with empty vector control cells ( EC ( EV ) ) . Regulation VCAM1 TNF 19320886 2052443 We aimed to investigate the *effect* of on the expression of intercellular adhesion molecule-1 ( ICAM-1 ) and [vascular cell adhesion molecule-1] ( VCAM-1 ) in the migration ability of mesenchymal stem cells ( MSCs ) in the context of wound healing . Regulation VCAM1 TNF 19875721 2187914 CD31 ( + ) cells purified from differentiating EBs upregulated ICAM-1 and [VCAM-1] in *response* to , confirming their ability to function as endothelial cells . Regulation VCAM1 TNF 20181103 2222764 This correlates with increased translocation of the transcription factor NF-kB to the nucleus , which is known to regulate ICAM-1 , [VCAM-1] and E-selectin expression in *response* to . Regulation VCAM1 TNF 20592773 2181648 We recently demonstrated that hyperglycemia increases oxidative stress and HBP flux in endothelial cells and enhances endothelial expression of [vascular adhesion molecule-1 (VCAM-1)] and intercellular adhesion molecule-1 ( ICAM-1 ) in *response* to through oxidative stress rather than HBP pathway . Regulation VCAM1 TNF 20966071 2354149 Here we show that DNA-PK is required for [VCAM-1] expression in *response* to . Regulation VCAM1 TNF 20966071 2354151 The phosphorylation and subsequent degradation of I-?Ba as well as the serine 536 phosphorylation and nuclear translocation of p65 NF-?B were insufficient for [VCAM-1] expression in *response* to . Regulation VCAM1 TNF 22405819 2577294 The strong inductive *effect* of on [VCAM-1] was counteracted by simvastatin and shear stress in an additive dose-response dependent way . Regulation VCAM1 TNF 22708120 2616096 Quantitative reverse transcriptase PCR and Western blot analyses indicated that IL-33 mediates the expression of intercellular adhesion molecule (ICAM)-1 and [vascular cell adhesion molecule (VCAM)-1] in endothelial cells basally and in *response* to . Regulation VCAM1 TNF 23934855 2850127 Shear stress modulates [VCAM-1] expression in *response* to and dietary lipids via interferon regulatory factor-1 in cultured endothelium . Regulation VCAM1 TNF 24370050 2882008 This study was aimed to explore the *effect* of on the [vascular cell adhesion molecule 1] ( VCAM-1 ) expression of human bone marrow mesenchymal stem cells ( BMMSC ) and the relationship between this process and ERK signalling pathway . Regulation VCAM1 TNF 24479486 2918449 Importantly , we observed pronounced *effects* of ß2-adrenergic receptor agonists and on IL-6 , CXCL2 , CXCL3 , [VCAM1] , and ICAM1 expression , suggesting a role in inflammatory brain cell homeostasis . Regulation VCAM1 TNF 7529260 291435 *Regulation* of [vascular cell adhesion molecule-1] expression by IL-4 and in cultured endothelial cells . Regulation VCAM1 TNF 7529260 291437 Using a combination of immunofluorescence , flow cytometry , and Northern analysis , we compared the *effect* of and IL-4 on [VCAM-1] expression . Regulation VCAM1 TNF 7691964 231058 These results with DMEC differ from human umbilical vein EC analyzed in parallel , which are completely CD36- and show transient ELAM-1 and sustained [VCAM-1] expression in *response* to and IL-1 . Regulation VCAM1 TNF 7693807 234228 Furthermore , although , preincubation of bEND.3 cells with IFN-gamma modestly increases the induction of ICAM-1 and [VCAM-1] in *response* to and IL-1 , it dramatically reduces the TNF-alpha , IL-1 , and LPS induced expression of MAdCAM-1 . Regulation VCAM1 TNF 8356403 227508 To establish whether EA-hy-926 could be used as a model for endothelial cells ( EC ) in leucocyte-EC adhesion interactions , the *effect* of interleukin-4 (IL-4) , or interferon-gamma (IFN) stimulation on their adhesiveness and expression of E-selectin , vascular cell adhesion molecule-1 ( [VCAM-1] ) and intercellular adhesion molecule-1 ( ICAM-1 ) was compared with that of HUVEC and A549 . Regulation VCAM1 TNF 8568264 350976 The TNF induced expression of [VCAM-1] and E-selectin was found to be exclusively *controlled* by the 55-kDa ( TNFRp55 ) as demonstrated by analysis of TNFRp55-/- mice . Regulation VCAM1 TNF 8665570 368713 These results indicate that serum , raised by surgical stress , is critically *involved* in the enhanced pulmonary metastasis of mouse melanoma by inducing [VCAM-1] expression on lung vascular endothelium . Regulation VCAM1 TNF 8879177 390695 may *play* a critical role in [VCAM-1] upregulation in this nonallergic eosinophilic disorder . Regulation VCAM1 TNF 9301536 453933 In contrast to the synergistic *effect* of IL-13 and on endothelial [vascular cell adhesion molecule-1] ( VCAM-1 ) surface expression , TNF-alpha induced secretion of MCP-1 is not augmented by IL-13 . Regulation VCAM1 TNF 9468519 486075 Role of activating protein-1 in the *regulation* of the [vascular cell adhesion molecule-1] gene expression by . Regulation VCAN CD14 11545252 855514 This study was performed to analyze the *involvement* of in the activation of human monocytes by [peptidoglycan monomer (PGM)] obtained by biosynthesis from culture fluid of penicillin treated Brevibacterium divaricatum NRLL-2311 . Regulation VCAN CD14 11545252 855517 Activation of human monocytes by [PGM] *involves* both forms of , sCD14 and mCD14 . Regulation VCP STK39 23907667 2861523 BRSK2 ( also known as SAD-A ) , a of the AMP activated protein kinase family *affected* [VCP/p97] activity in ERAD . Regulation VDR CAPN8 15225804 1268450 Additionally , modulation of cell proliferation by inhibitors , as well as *regulation* of mRNA expression of [VDR] , 1alpha-OHase , and 24-OHase genes by Vitamin D analogs were assessed in melanoma cell lines in vitro using a WST-1 based colorimetric assay and real-time PCR , respectively . Regulation VDR EPHB2 15331595 1323252 However , the *effect* of activation on [VDR] transcriptional activity was cell line-specific . Regulation VDR TNF 22182686 2543317 This effect is mediated by the [VDR] and might *involve* direct inhibition of . Regulation VDR TNF 22880111 2641782 *Effect* of on the activity and expression of [VDR] was analyzed by luciferase assay , immunoblotting and immunocytochemistry . Regulation VDR TNF 9723887 529272 The *effect* of on RXR and [VDR] binding to their cognate response elements and stimulation of transcription was studied in VDR deficient CV-1 and COS-7 cells . Regulation VDR TP63 17716971 1801397 In conclusion , our results indicate that [VDR] is *regulated* by and p73 and that the induction of VDR expression upon DNA damage is p73 dependent . Regulation VEGFA ANGPT1 11805186 903457 Human podocytes express , a potential *regulator* of glomerular [vascular endothelial growth factor] . Regulation VEGFA ANGPT1 19106103 2036489 Furthermore , depletion of KLF2 resulted in the loss of the inhibitory *effect* of on vascular endothelial growth factor ( VEGF ) -mediated expression of vascular cell adhesion molecule-1 in endothelial cells and [VEGF] mediated monocyte adhesion to endothelial cells . Regulation VEGFA ARSA 18544566 1952217 The expression of vascular endothelial growth factor ( [VEGF] ) was significantly reduced in *response* to , with the p- isomer being more potent than the m- . Regulation VEGFA BPI 18055828 1833403 Moreover , heparitinase also inhibited *actions* on [VEGF] and PDGF-B mRNA expression induced by H ( 2 ) O ( 2 ) . Regulation VEGFA CCND1 16899623 1601250 Small interfering RNA against cyclin D1 was also used to analyze inhibition associated [vascular endothelial growth factor] ( VEGF ) *regulation* . Regulation VEGFA CTGF 18835464 2012822 CCN family <2/connective tissue growth factor> ( CCN2/CTGF ) *regulates* the expression of [Vegf] through Hif-1alpha expression in a chondrocytic cell line , HCS-2/8 , under hypoxic condition . Regulation VEGFA EGLN3 24067973 2863159 ANDV infection in combination with hypoxic conditions resulted in the enhancement of hypoxia-inducible factor 1a (HIF1a) directed [VEGF A] , angiopoietin 4 , and transcriptional *responses* . Regulation VEGFA EPHB2 11694503 896378 Overexpression of DN and Ras had no *effect* on [VEGF] expression in these cells . Regulation VEGFA EPHB2 16164642 1456360 and VEGF stimulated eNOS phosphorylation on Ser1177 was prevented by PD098059 , an upstream inhibitor of ERK , demonstrating that was *involved* in [VEGF] regulation of eNOS . Regulation VEGFA EPHB2 16530725 1536436 Inhibitors of either extracellular signal regulating kinase ( ERK ) or phosphatidylinositol 3-kinase (PI3K) partly reversed the thrombin induced cytokine expression , suggesting that both and PI3K kinase pathways may be *involved* in IL-8 and [VEGF] expression . Regulation VEGFA EPHB2 17685427 1788264 Altogether our results described a new link between constitutive activity and the *regulation* of [VEGF] expression two common denominators implicated in tumor angiogenesis . Regulation VEGFA EPHB2 19098317 2047605 *Role* of PI3K/Akt and in mediating hypoxia induced expression of HIF-1alpha and [VEGF] in laser induced rat choroidal neovascularization . Regulation VEGFA EPHB2 19765632 2183492 Early ERK activation is involved in AGT upregulation and sustained activation , mediated via AT1 , is *responsible* for [VEGF] synthesis . Regulation VEGFA EPHB2 19874715 2156814 Furthermore , a pharmacological inhibitory study revealed that G ( alpha i/o ) -mediated phospholipase C , Akt , , and p38 MAPK signaling are *involved* in this S1P induced expression of [VEGF] . Regulation VEGFA EPHB2 20141840 2208142 Mechanistically , K5-SOS upregulates [VEGF] , Flt1 , and Neuropilin-1 in an *dependent* manner , thereby activating an autocrine proliferation loop , whereas EGFR prevents tumor cells from apoptosis . Regulation VEGFA EPHB2 20160089 2215008 SP-induced [VEGF] production *involves* calcium dependent PKC isoforms , as well as the and JNK MAPKs . Regulation VEGFA EPHB2 23167467 2700280 Our results suggest that EMD stimulates VEGF production partially via TGF-ß1 and FGF-2 in human gingival fibroblasts and that EMD induced [VEGF] production is *regulated* by , p38 MAPK , and PI3K/Akt pathways . Regulation VEGFA F2R 19308689 2007675 Notably , in many tumor types including melanoma , expression directly correlates with their metastatic phenotype and is directly *responsible* for the expression of interleukin-8 , matrix metalloproteinase-2 (MMP-2) , [vascular endothelial growth factor] , platelet derived growth factor , and integrins . Regulation VEGFA FOXO1 22384192 2566325 We found binds to the VEGF-A promoter and *regulates* [VEGF-A] transcription in ß cells . Regulation VEGFA HBEGF 11139469 770073 Ang II also upregulated vascular endothelial growth factor ( [VEGF] ) expression in an *dependent* manner . Regulation VEGFA HBEGF 11139469 770078 In an in vivo corneal assay , AT(1) induced angiogenesis in an *dependent* manner and enhanced the angiogenic activity of [VEGF] . Regulation VEGFA HBEGF 15988409 1429318 expression in fibroproliferative tissue and its stimulatory *effect* on glial cell proliferation , chemotaxis , and [VEGF] secretion suggest that HB-EGF may be a factor mediating glial cell responses during PVR . Regulation VEGFA HBEGF 21854110 2496053 *Effect* of and amphiregulin on the MAP kinase induced production of [vascular endothelial growth factor] by human granulosa cells . Regulation VEGFA HBEGF 23443317 2781131 We show that *regulates* the expression of [VEGFA] or ANGPTL4 via transcriptional regulation of hypoxia-inducible factor-1a and NF-?B . Regulation VEGFA IFI27 21063843 2344975 *Effects* of gene transfer on the expression of Bax , Bcl-2 , [VEGF] and MMP-9 in the transplanted liver tumors in nude mice . Regulation VEGFA IL1B 10408390 629817 *Regulation* of [vascular endothelial growth factor] expression in human colon cancer by . Regulation VEGFA IL1B 10408390 629822 These findings suggest that *regulates* [VEGF] expression in human colon cancer cells by increasing transcription of the VEGF gene . Regulation VEGFA IL1B 10732316 678310 Periovulatory and *dependent* up-regulation of intraovarian [vascular endothelial growth factor] ( VEGF ) in the rat : potential role for VEGF in the promotion of periovulatory angiogenesis and vascular permeability . Regulation VEGFA IL1B 10732316 678311 It is tempting to speculate that the up-regulatory *effect* of on [VEGF] transcripts may be relevant to the marked angiogenesis and increased vascular permeability displayed by the hyperemic ovarian Graafian follicle during the terminal stages of follicular development . Regulation VEGFA IL1B 11040101 741897 In this study , we examined the *effects* of on the expression of vascular endothelial cell growth factor ( [VEGF] ) and pursued the molecular mechanisms underlying this effect . Regulation VEGFA IL1B 11806247 892603 We investigated the *effects* of on [VEGF] expression in human VSMCs ( hVSMCs ) and the signal transduction pathways that may be involved . Regulation VEGFA IL1B 14960485 1242925 These data indicate that , in normal human cytotrophoblast cells , IL-1 beta induces HIF- 1 alpha mediated [VEGF] secretion and that stimulated ERK1/2 activation may be *involved* in this process . Regulation VEGFA IL1B 15126358 1244843 We previously demonstrated that *regulates* [VEGF] expression in tumor cells . Regulation VEGFA IL1B 15665043 1402419 IL-1beta also synergizes with OSM to increase VEGF release , likely as a result of *effects* of on [VEGF] mRNA stability as well as effects of OSM on IL-1R1 expression . Regulation VEGFA IL1B 16385078 1520070 Additionally , iNOS-deficient SMCs showed a low level of [VEGF] production in *response* to stimulation . Regulation VEGFA IL1B 16565972 1549856 Differential expression of [VEGF-A] and angiopoietins in cartilage tumors and *regulation* by . Regulation VEGFA IL1B 16565972 1549857 As interleukin (IL)-1beta has been found to be an indispensable factor in angiogenic signaling , we further analyzed the *effect* of on the expression of [VEGF-A] , Ang-1 , and Ang-2 using a previously established cell culture model . Regulation VEGFA IL1B 16565972 1549862 *regulated* [VEGF-A] and Ang-1 expressions in a dose dependent manner . Regulation VEGFA IL1B 17035941 1649229 In the present work , we studied the *effect* of on [VEGF] release by rat mesangial cells , the transduction signal , and whether or not PGE2 is involved in this effect . Regulation VEGFA IL1B 17071533 1637656 *regulates* [vascular endothelial growth factor] and soluble fms-like tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts . Regulation VEGFA IL1B 17071533 1637662 The secretion of [VEGF] and sFlt-1 by cultured OECs and OSFs in *response* to and IL-1 receptor antagonist (IL-1RA) was measured using an enzyme linked immunosorbent assay . Regulation VEGFA IL1B 19474288 2102345 [Vascular endothelial growth factor] expression in cultured DSCs increased in *response* to stimulation with ( IL-1 beta ; 0.01-10 ng/mL ) -- but not tumor necrosis factor alpha ( TNF-alpha ; 1 ng/mL ) -- in a concentration dependent fashion irrespective of the hormonal milieu . Regulation VEGFA MAP2K6 19098317 2047614 *Role* of PI3K/Akt and in mediating hypoxia induced expression of HIF-1alpha and [VEGF] in laser induced rat choroidal neovascularization . Regulation VEGFA MAP2K6 21167264 2390784 *Effects* of DNMT and inhibitors on the expression of RECK , MMP-9 , -2 , uPA and [VEGF] in response to arsenite stimulation in human uroepithelial cells . Regulation VEGFA MMP28 16152587 1517301 Using the Matrigel invasion assay and colloidal gold phagokinetic track assay , we found that [VEGF] induced EOC DOV13 invasion and migration in a *dependent* manner . Regulation VEGFA MMP28 19558529 2149602 Impairment of ischaemia induced EPC mobilization in the diabetic mouse model is associated with altered HIF-1 [alpha/VEGF] and *regulation* and represents a novel mechanism underlying defective postischaemic neovascularization in diabetes . Regulation VEGFA MMP7 16152587 1517316 Using the Matrigel invasion assay and colloidal gold phagokinetic track assay , we found that [VEGF] induced EOC DOV13 invasion and migration in a *dependent* manner . Regulation VEGFA MMP7 19558529 2149617 Impairment of ischaemia induced EPC mobilization in the diabetic mouse model is associated with altered HIF-1 [alpha/VEGF] and *regulation* and represents a novel mechanism underlying defective postischaemic neovascularization in diabetes . Regulation VEGFA PGC 23141926 2717877 These results demonstrate that *regulates* [VEGFA] in the retina and is required for normal vessel development and for pathological neovascularization . Regulation VEGFA S100B 21889514 2539099 *dependent* [VEGF] secretion by cardiac myocytes induces myofibroblast proliferation . Regulation VEGFA TNF 10833366 697681 These results suggest that both and TGF-beta1 may *regulate* the production of [VEGF] in early gestational trophoblasts and may therefore serve to modulate placental vascular permeability and angiogenesis that are necessary for embryo implantation and placentation . Regulation VEGFA TNF 11244034 792276 Clinical investigations in which the activity of TNF alpha in RA patients was blocked with intravenously administered infliximab , a chimeric anti-TNF alpha monoclonal antibody ( mAB ) , has provided evidence that *regulates* IL-6 , IL-8 , MCP-1 , and [VEGF] production , recruitment of immune and inflammatory cells into joints , angiogenesis , and reduction of blood levels of matrix metalloproteinases-1 and -3 . Regulation VEGFA TNF 12389595 1000387 These results suggest that IL-1beta , IFN-gamma , and may *regulate* the production of [VEGF] in early gestational trophoblasts . Regulation VEGFA TNF 12551841 1064176 Addition of a hexapeptide ( Ac-KWIIVW-NH2 ) , known to block TNF-alpha binding to its receptors , abrogated this *effect* on [VEGF] mRNA induction . Regulation VEGFA TNF 12574959 1057935 IL-6 and are *involved* in the secretion of [VEGF] by IL-6r expressing myeloma cells . Regulation VEGFA TNF 14872107 1208423 To assess the *involvement* of IL-6 and in [VEGF] increases in patients with severe OSAHS , serum levels of IL-6 and TNF-alpha were determined in patients with severe OSAHS ( n=110 ) and compared to those of controls ( n=45 ) using an enzyme linked immunosorbent assay . Regulation VEGFA TNF 14962263 1208672 Current data suggest that the action of thalidomide is related to several different mechanisms , including suppression of , *effects* on basic fibroblast growth factor , [vascular endothelial growth factor] , interleukins and interferons , downregulation of selected cell surface adhesion molecules , and changes in the lymphocyte subsets . Regulation VEGFA TNF 15555625 1340070 Expression and *regulation* of neuropilins and [VEGF] receptors by in human endothelial cells . Regulation VEGFA TNF 15999273 1498058 To compare the effect of oral glucocorticoid ( GC ) therapy with the *effect* of intravenous on serum [VEGF] levels of patients with rheumatoid arthritis ( RA ) . Regulation VEGFA TNF 16190362 1462605 In the present study , we examined the *effects* of hypoxia and on PAI-1 , MCP-1 and [VEGF] expression in cultured human proximal renal tubular cells ( HPTECs ) . Regulation VEGFA TNF 16728464 1612355 Human progenitor cells from bone marrow or adipose tissue produce [VEGF] , HGF , and IGF-I in *response* to by a p38 MAPK dependent mechanism . Regulation VEGFA TNF 17070836 1675189 Gender differences in injury induced mesenchymal stem cell apoptosis and [VEGF] , TNF , IL-6 expression : *role* of the 55 kDa receptor ( TNFR1 ) . Regulation VEGFA TNF 17084400 1675706 *regulates* [vascular endothelial growth factor] secretion by human oviductal epithelial cells and stromal fibroblasts . Regulation VEGFA TNF 17240354 1690571 These results suggest that p38 MAPK and are *involved* in the [VEGF] expression induced by HKLM in RAW264.7 cells . Regulation VEGFA TNF 17509611 1751077 In *response* to hypoxia or , MSCs produced more [VEGF] , which was correlated with hypoxia or TNF activated p38 MAPK and STAT3 . Regulation VEGFA TNF 17906365 1803237 The data suggest that HASMC express [VEGF] in *response* to and that this may be reduced in HASMC of smokers with COPD in a smoking independent manner . Regulation VEGFA TNF 18759025 1034512 In addition , the *effect* of on [VEGF] expression was examined . Regulation VEGFA TNF 18759025 1034514 [VEGF] may be implicated in the CL formation and maintenance via regulating angiogenesis , and its expression is *regulated* by . Regulation VEGFA TNF 19628074 2112824 Conversely , the *effects* of and/or TGF-alpha on MSC [VEGF] production were significantly decreased , and MEK/ERK activation was negated in cells transfected TNFR2 siRNA . Regulation VEGFA TNF 20586953 2285671 Thus , we have investigated whether luteinizing hormone ( LH ) and may *affect* [VEGF] secretion by stromal cells during early pregnancy in pigs . Regulation VEGFA TNF 20617373 2418889 Expression of interleukin (IL)-6 , IL-8 , and were substantially increased and *involved* in macrophage induced [VEGF] and MMP-9 mRNA expression in MCF-7 cells . Regulation VEGFA TNF 20690185 2368103 In this study , we investigated the *effects* of inflammatory cytokines , IL-1ß , and , on the expression of an angiogenic factor , vascular endothelial growth factor ( [VEGF] ) , and neurotrophic factors , nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) , in human IVD degeneration . Regulation VEGFA TNF 21673619 2538695 Prior macrophage exposure increased the secretion of IL-8 and [VEGF] in *response* to stimulation whereas IL-6 production was increased in response to IL-1ß . Regulation VEGFA TNF 8755661 377430 To explore the possibility that the two interact to regulate endothelial cell proliferation , we examined the *effect* of on [VEGF] receptor expression . Regulation VEGFA TNF 9199336 438916 Administration of a NF-kappaB antisense oligonucleotide almost completely inhibited TNF-alpha dependent IL-8 production and partially abrogated TNF-alpha dependent VEGF production , and an Sp1 antisense sequence partially inhibited *dependent* production of [VEGF] . Regulation VEGFA TP63 11971180 933602 These results suggest that is *involved* in the regulation of the [VEGF] gene expression and that modulation of VEGF expression by TAp63gamma and dNp63alpha is closely correlated with their distinct roles on the regulation of HIF1alpha stability . Regulation VEGFC EMP1 24338711 2926797 *regulates* caspase-9 and [VEGFC] expression and suppresses prostate cancer cell proliferation and invasion . Regulation VIM EPHB2 11001858 734556 The localization of smooth muscle alpha -actin , myosin heavy chain isoform SM2 , and [vimentin] in explant isolated rat SMCs was *affected* by a substrate of fibronectin and laminin and also by MAP kinase inhibitor ( PD098059 ) and P38 MAPK inhibitor ( SB203580 ) . Regulation VIM IL1B 7931319 275265 To study the *effect* of recombinant human ( rhIL-1 beta ) on astrocyte morphology , glial fibrillary acidic protein (GFAP) and [vimentin] expression , and actin organization , we conducted a systematic survey using dissociated human fetal astrocyte cultures . Regulation VIP IL1B 17683829 1794176 Therefore , we first tested the *effects* of peripheral on [VIP] and PACAP central production . Regulation VIP TNS1 8874676 389988 We examined the *effect* of on esophageal motility and [vasoactive intestinal peptide (VIP)] levels in normal subjects . Regulation VIPR2 TLR7 20196778 2180943 We now report that different ligands selectively *regulate* the [VPAC(2)] receptor gene and show a gene repression system controlled by key protein kinase signalling cascades in macrophages . Regulation VLDLR PCSK9 21273557 2403166 In vivo , endogenous *regulates* [VLDLR] protein levels in adipose tissue . Regulation VLDLR PCSK9 23221398 2731346 is *involved* in the degradation of LDLR and [VLDLR] . Regulation VMA21 ATP6V0A4 15356264 1323697 Although [Vma21p/proteolipid] interactions were *independent* of , Vma21p/Vph1p association was dependent on all other V0 subunits , indicating that assembly of V0 occurs in a defined sequence , with Vph1p recruitment into a Vma21p/proteolipid/Vma6p complex representing the final step . Regulation VRK1 CCND1 18713830 1955563 Here we show that [VRK1] *regulates* cell cycle progression in the DNA replication period by inducing expression . Regulation VSNL1 CA2 18925431 2028659 In order to test this hypothesis we have investigated whether a nicotine induced and reversible Ca2+-myristoyl switch of VILIP-1 exists in primary hippocampal neurons and whether pharmacological agents , such as antagonist specific for distinct nAChRs , can interfere with the *dependent* membrane localization of [VILIP-1] . Regulation VSNL1 P2RX2 22090499 2509134 Moreover , lateral mobility is subunit and cell specific , is increased in an activation dependent manner , and is *regulated* by cytosolic [VILIP1] , a calcium binding protein . Regulation VTN NR2F1 12040019 949618 After showing that COUP-TFI is phosphorylated in vivo , we provide evidence that in vivo inhibition of either MAPK or PKC signaling pathway leads to a specific and pronounced decrease in *dependent* transcriptional activation of the [vitronectin] gene promoter . Regulation VWF ARSA 1295515 208792 [ *Effect* of on the interaction of [von Willebrand factor] with the platelet membrane ] . Regulation VWF HES2 9308738 454591 Of particular importance is the fact that with a high in vivo MW *affects* factor [VIII/von Willebrand factor] which can lead to an acquired von Willebrand syndrome . Regulation VWF TNF 1509401 196523 To investigate the *effect* of on the release of [von Willebrand factor (vWF)] into the circulation , we performed a controlled study in six healthy men , sequentially measuring the plasma concentrations of vWF antigen after a bolus intravenous injection of recombinant human TNF ( 50 micrograms/m2 ) . Regulation WAS CAPN8 9731041 530419 Lastly , we found that [WASP] is cleaved in *response* to activation of , a protease that may have a role in postaggregation signaling processes . Regulation WDR61 ALOX5 3152458 104202 This suggests that <5-lipoxygenase> *dependent* mediators and [PAF] are involved in allergic contact dermatitis and that these mediators play only a minor role in irritant dermatitis . Regulation WDR61 ALOX5 7488299 323022 This study has examined the *effects* of a new <5-lipoxygenase> inhibitor , 6-hydroxy-2- ( 4-sulfamoylbenzylamino ) -4,5,7-trimethylbenzothiazo le hydrochloride ( CAS 120164-49-0 , E6080 ) on the release of LTC4 , LTB4 and [PAF] by human eosinophils , Eosinophils stimulated by 1 mumol/l calcium ionophore A23187 for 15 min released 37.5 +/- 2.2 ng , 2.3 +/- 0.3 ng and 4.0 +/- 0.3 pmol per 10 ( 6 ) cells of immunoreactive LTC4 , LTB4 and PAF , respectively ( mean +/- SEM , n = 4 ) . Regulation WDR61 ARSA 8107285 246011 Next , synthesized PAF from washed platelets or washed leukocytes stimulated with collagen or ONO-11113 ( STA2 ; stable analogue of thromboxane A2 ) , and the inhibiting *effects* of on the [PAF] synthesis from collagen stimulated leukocytes were examined , using a radioimmunoassay kit for PAF . Regulation WDR61 EDN2 2051719 161779 The purpose of the present series of experiments has been to analyze the functional relations between the *effect* of on renal function and glomerular and mesangial cell contraction and the production and actions of [PAF] in kidney . Regulation WDR61 F2R 10395981 627775 The *effect* of a agonist peptide ( TRAP-6 ) on the release of nitric oxide ( NO ) and [platelet activating factor (PAF)] from resting and calcium-ionophore ( A23187 ) -activated rat peritoneal mast cells ( RPMC ) was studied using a platelet aggregation bioassay . Regulation WDR61 TNF 1499148 193557 4. Furthermore , we investigated the priming *effect* of recombinant human , which is known to be one of the most important mediators in the development of ARDS , on [PAF] production induced by the calcium ionophore in neutrophils . Regulation WDR61 TNF 1846897 153388 We have further examined the *effects* of on arachidonic acid ( AA ) release , LTB4 production , and [platelet activating factor (PAF)] formation in PMN by prelabeling cells with either [ 3H ] AA or [ 3H ] lyso-PAF , priming with human rTNF-alpha , and then stimulating with the chemotactic peptide , FMLP . Regulation WDR61 TNF 3119758 80243 Synthesis of [PAF] in *response* to was also detected in rat polymorphonuclear neutrophils , but not in human tumor cells and dermal fibroblasts . Regulation WDR61 TNF 3261295 96002 About 30 % of [PAF] produced in *response* to either or IL-1 is released into the medium , whereas approximately 70 % remains cell associated . Regulation WDR61 TNF 3261295 96014 Experiments with labeled precursors show that [PAF] is synthesized de novo in *response* to . Regulation WDR61 TNF 3261295 96025 This suggests that [PAF] is synthesized by the same pathway in *response* to or IL-1 . Regulation WDR61 TNF 8488366 219200 In contrast to its effect on the AA turnover , did not *affect* the phospholipase C-stimulated production of platelet activating factor ( [PAF-acether] ) . Regulation WDR61 TNF 9187959 437089 GM-CSF production by EC was also stimulated by the combined effects of PAF and , but [PAF] alone did not *affect* GM-CSF production . Regulation WIF1 MYC 20697356 2340810 Transcriptional *regulation* of [Wnt inhibitory factor-1] by . Regulation WIF1 MYLIP 23939044 2835862 Methylation-specific PCR and Western blotting indicated that positively *regulate* [WIF-1] expression by inhibiting the methylation of its promoter . Regulation WIF1 SMAD1 21986617 2539642 directly *regulates* [Wif1] gene expression and blockade of Smad1 function in fetal LECs is reported to downregulate Wif1 gene expression . Regulation WIF1 WNT1 22008465 2547443 Blocking signaling by the Wnt antagonist IWR-1 did not *affect* [wif1] expression in the swimbladder , but complete suppression of Hedgehog signaling in smo-/- mutants abolished wif expression , consistent with our earlier report of a negative feedback regulation of Wnt signaling in the swimbladder by the Hedgehog signaling . Regulation WIF1 WNT11 22008465 2547444 Blocking signaling by the Wnt antagonist IWR-1 did not *affect* [wif1] expression in the swimbladder , but complete suppression of Hedgehog signaling in smo-/- mutants abolished wif expression , consistent with our earlier report of a negative feedback regulation of Wnt signaling in the swimbladder by the Hedgehog signaling . Regulation WIF1 WNT16 22008465 2547449 Blocking signaling by the Wnt antagonist IWR-1 did not *affect* [wif1] expression in the swimbladder , but complete suppression of Hedgehog signaling in smo-/- mutants abolished wif expression , consistent with our earlier report of a negative feedback regulation of Wnt signaling in the swimbladder by the Hedgehog signaling . Regulation WIF1 WNT2 22008465 2547445 Blocking signaling by the Wnt antagonist IWR-1 did not *affect* [wif1] expression in the swimbladder , but complete suppression of Hedgehog signaling in smo-/- mutants abolished wif expression , consistent with our earlier report of a negative feedback regulation of Wnt signaling in the swimbladder by the Hedgehog signaling . Regulation WIF1 WNT3 22008465 2547446 Blocking signaling by the Wnt antagonist IWR-1 did not *affect* [wif1] expression in the swimbladder , but complete suppression of Hedgehog signaling in smo-/- mutants abolished wif expression , consistent with our earlier report of a negative feedback regulation of Wnt signaling in the swimbladder by the Hedgehog signaling . Regulation WIF1 WNT4 22008465 2547447 Blocking signaling by the Wnt antagonist IWR-1 did not *affect* [wif1] expression in the swimbladder , but complete suppression of Hedgehog signaling in smo-/- mutants abolished wif expression , consistent with our earlier report of a negative feedback regulation of Wnt signaling in the swimbladder by the Hedgehog signaling . Regulation WIF1 WNT6 22008465 2547448 Blocking signaling by the Wnt antagonist IWR-1 did not *affect* [wif1] expression in the swimbladder , but complete suppression of Hedgehog signaling in smo-/- mutants abolished wif expression , consistent with our earlier report of a negative feedback regulation of Wnt signaling in the swimbladder by the Hedgehog signaling . Regulation WIF1 ZBTB17 20697356 2340809 Transcriptional *regulation* of [Wnt inhibitory factor-1] by . Regulation WIF1 ZBTB17 20697356 2340811 In addition , we show that c-Myc contributes to [WIF-1] transcriptional repression in a *dependent* manner . Regulation WISP1 TNF 24600972 2925058 The *effects* of and TGF-beta1 on [WISP-1] expression were analyzed in stellate cell lines HSC-T6 and LX-2 . Regulation WNK1 ARSA 22306536 2565243 did not *affect* total NF-?B [p65] , but inhibited its phosphorylation and activation . Regulation WNK1 FAS 12934082 1132797 The total levels of p50 , p65 and IkappaBalpha remain unchanged , but the levels of phosphorylated IkappaBalpha and of nuclear [p65] increase , in *response* to . Regulation WNK1 IL1B 10644648 661128 These data suggest that constitutive NF-kappaB [p65] protein synthesis is *regulated* by , particularly during pregnancy . Regulation WNK1 IL1B 19843519 2170100 Histone deacetylase-1 is enriched at the platelet derived growth factor-D promoter in *response* to and forms a cytokine-inducible gene silencing complex with NF-kappab [p65] and interferon regulatory factor-1 . Regulation WNK1 MIP 24360910 2905498 The goal of this study was to understand how p65/RelA co-regulated genes , specifically those of the cytokine and endocannabinoid systems , were affected in HD. p65/RelA levels were lower in human HD tissue and R6/2 HD mice , as were the levels of the type 1 cannabinoid receptor ( CB1 ) , IL-1ß , IL-8 , CCL5 , GM-CSF , , and TNFa , all of which may be *regulated* by [p65/RelA] . Regulation WNK1 TLR7 18523248 1922759 SP-A decreases the phosphorylation of IkappaBalpha , a key regulator of NF-kappaB activity , and nuclear translocation of [p65] which result in diminished TNF-alpha secretion in *response* to ligands . Regulation WNK1 TNF 11450703 836644 Treatment with proteasome inhibitors inhibited the degradation of both IkappaB-alpha and IkappaB-beta and prevented the *dependent* nuclear translocation of [p65] . Regulation WNK1 TNF 15485901 1320917 SIMPL interacts with nuclear [p65] in a *dependent* manner to promote endogenous NF-kappaB dependent gene expression . Regulation WNK1 TNF 20130413 2293656 TSA also attenuated constitutive and *dependent* [p65] phosphorylation and nuclear translocation in endometriotic cells . Regulation WNK1 TNF 22895565 2713534 Interestingly , reduction of MMS22L by siRNAs in cancer cells inhibited the *dependent* activation of [RelA/p65] in the NFKB pathway and expression of its downstream anti-apoptotic molecules such as Bcl-XL and TRAF1 . Regulation WNK1 TNF 23339680 2738493 In the study , we designed to investigate the *effect* of on the activation and expression of nuclear factor kappa B ( NF-?B ) [/p65/SLUG/PUMA/Bcl-2] levels in human lung cancer A549 cell line , and in conditions of TNF-a induced apoptosis . Regulation WNK1 TNF 23630580 2779103 SIMPL enhancement of *dependent* [p65-MED1] complex formation is required for mammalian hematopoietic stem and progenitor cell function . Regulation WNK1 TNF 7843230 294059 , therefore , emerges as the main factor responsible for a second phase of NF-kappa B regulation , *controlling* both translocation of [p65] and c-rel , and new mRNA synthesis for c-rel and p105/p50 . Regulation WNK1 TNF 9528954 496217 The treatment with the antioxidants 20 mM N-acetyl-L-cysteine (NAC) and 10 microM pyrrolidine dithiocarbamate ( PDTC ) inhibited the *dependent* activation of [p65-p50] heterodimer but not the p50-p50 homodimer , indicating that generation of oxidants is required for the activation of the heterodimer NF-kappaB . Regulation WNT1 ARSA 22198215 2563569 The current study analyses the *effect* of <5-ASA> on [Wnt/ß-catenin] signaling in vitro and in vivo in colon epithelial cells . Regulation WNT1 AXIN2 10196136 604265 Phosphorylation of , a [Wnt] signal negative *regulator* , by glycogen synthase kinase-3beta regulates its stability . Regulation WNT1 AXIN2 10488109 645226 , a [Wnt] signal negative *regulator* , enhances glycogen synthase kinase (GSK)-3beta dependent phosphorylation of beta-catenin and stimulates the degradation of beta-catenin . Regulation WNT1 AXIN2 11809809 906817 [Wnt] signaling is *controlled* by the negative regulator , which induces degradation of beta-catenin by functional interaction with the tumor suppressor APC and the serine/threonine kinase GSK3beta . Regulation WNT1 AXIN2 12192039 980772 These data reveal for the first time that I-mfa domain proteins interact with the Axin complex and affect *regulation* of both the [Wnt] and the JNK activation pathways . Regulation WNT1 AXIN2 12569091 1071840 *regulates* [Wnt] signaling through down-regulation of beta-catenin . Regulation WNT1 AXIN2 12925589 1131259 A subset of embryos also show a shortening of the anterior-posterior axis and frequent duplication of axial structures that are strikingly similar to the phenotypes associated with deficiency , a critical *regulator* of [Wnt] signaling . Regulation WNT1 AXIN2 15063782 1230968 , a negative *regulator* of [Wnt] , forms a complex with glycogen synthase kinase 3beta , beta-catenin , and adenomatous polyposis coli and promotes GSK3beta dependent phosphorylation of beta-catenin , thereby stimulating degradation of the beta-catenin . Regulation WNT1 AXIN2 17404238 1721622 Conditional beta cell expression of , a potent negative *regulator* of [Wnt] signaling , led to reduced Pitx2 and Cyclin D2 expression by beta cells , resulting in reduced neonatal beta cell expansion and mass and impaired glucose tolerance . Regulation WNT1 AXIN2 19075000 2030702 N-cadherin interacts with and LRP5 to negatively *regulate* [Wnt/beta-catenin] signaling , osteoblast function , and bone formation . Regulation WNT1 AXIN2 19075000 2030804 These data indicate that a previously unrecognized interaction negatively *regulates* [Wnt/beta-catenin] signaling and is critical in the regulation of osteoblast function , bone formation , and bone mass . Regulation WNT1 AXIN2 19331826 2064614 However , the role of , a negative *regulator* of [Wnt] signaling , in mitosis has remained unclear . Regulation WNT1 AXIN2 20858899 2342913 The protein stability of , a negative *regulator* of [Wnt] signaling , is regulated by Smad ubiquitination regulatory factor 2 ( Smurf2 ) . Regulation WNT1 AXIN2 21242974 2425495 , a negative *regulator* of [Wnt] signaling , is a key scaffold protein for the ß-catenin destruction complex . Regulation WNT1 AXIN2 21555575 2435412 Tissue-specific *roles* of in the inhibition and activation of [Wnt] signaling in the mouse embryo . Regulation WNT1 AXIN2 22191557 2543413 Because *controls* canonical [Wnt] signaling , we conducted an investigation to determine whether the cardiogenic activity of 1 is Wnt dependent , and we developed a structure-activity relationship to optimize the cardiogenic properties of 1 . Regulation WNT1 AXIN2 22322943 2592175 [Wnt/ß-catenin] signalling regulates cell proliferation by modulating the cell cycle and is negatively *regulated* by . Regulation WNT1 AXIN2 22322943 2592204 We propose that CDC20 mediated degradation of *regulates* [Wnt/ß-catenin] signalling for maximal activity during G1/S . Regulation WNT1 AXIN2 22509369 2584179 dependent *regulation* of [Wnt] is important for various developmental processes and human diseases . Regulation WNT1 AXIN2 22711842 2621373 Mutation of , the negative *regulator* of canonical [Wnt] signaling , enhances Wnt and Bmp4 signals and suffices to rescue the arrest of cardiac differentiation caused by loss of RBPJ . Regulation WNT1 AXIN2 22773187 2639624 DP1 negatively *regulates* [Wnt/ß-catenin] signalling by inhibiting interaction and by enhancing poly-ubiquitination of ß-catenin . Regulation WNT1 AXIN2 22957046 2667772 Differential *role* of RGS domain function in [Wnt] signaling during anteroposterior patterning and maternal axis formation . Regulation WNT1 AXIN2 23525146 2777361 Furthermore , deletion of , a negative intracellular *regulator* of canonical [Wnt] signaling , rescues the tooth defects in mice carrying Gpr177 mutation in the dental epithelium . Regulation WNT1 AXIN2 23959799 2845455 Here , we report a novel function of Smurf1 in *regulating* [Wnt/ß-catenin] signaling through targeting for nonproteolytic ubiquitination . Regulation WNT1 FOXO1 22550000 2669351 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced *dependent* inhibition of [Wnt/TCF] activity . Regulation WNT1 KLF9 22259059 2564447 The aims were to investigate 1 ) KLF9 expression in eutopic endometrium of women with and without endometriosis , 2 ) *effects* of attenuated KLF9 expression on WNT signaling component expression and on [WNT] inhibitor Dickkopf-1 promoter activity in human endometrial stromal cells ( HESC ) , and 3 ) PGR and coregulation of the stromal transcriptome network . Regulation WNT1 MSX1 19815336 2209334 These results suggest *involvement* of in [Wnt] signalling and demonstrate activity of the more upstream Wnt pathway in neuroblastic cells . Regulation WNT1 NRARP 16228014 1489379 These findings reveal that independently *regulates* canonical [Wnt] and Notch signalling by modulating LEF1 and Notch protein turnover , respectively . Regulation WNT1 NRARP 19268448 2063133 These include Uncx , a somite gene required for rib and vertebral patterning , and , a *regulator* of [Notch/Wnt] signaling in zebrafish and a cycling gene in mouse . Regulation WNT1 TNF 11203701 785457 signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is *regulated* by [Wnt] and activin during tooth organogenesis . Regulation WNT1 TNF 18433704 1900226 TOPGAL mice exhibit greater beta-galactosidase reporter staining versus TOPGAL siblings in the aorta and coronaries , which indicates enhanced mural [Wnt] signaling in *response* to . Regulation WNT1 WIF1 18586116 1953405 Our data shows that the expression of Wif1 was very strong during embryonic development of the CNS and suggests that may *play* an essential role in the spatial and temporal regulation of [Wnt] signals . Regulation WNT1 WIF1 21928342 2539161 Conversely , CTGF does not interfere with *dependent* inhibition of [Wnt] signalling . Regulation WNT1 WIF1 22383891 2566215 The role of glypicans in Wnt inhibitory factor-1 activity and the structural basis of 's *effects* on [Wnt] and Hedgehog signaling . Regulation WNT1 WIF1 23784913 2838640 In chondrocytes , TNFa stimulated canonical Wnt signaling , which could be blocked by WIF-1 , indicating a direct *effect* of TNFa and on [Wnt] signaling in this system . Regulation WNT11 ARSA 22198215 2563570 The current study analyses the *effect* of <5-ASA> on [Wnt/ß-catenin] signaling in vitro and in vivo in colon epithelial cells . Regulation WNT11 AXIN2 10196136 604267 Phosphorylation of , a [Wnt] signal negative *regulator* , by glycogen synthase kinase-3beta regulates its stability . Regulation WNT11 AXIN2 10488109 645228 , a [Wnt] signal negative *regulator* , enhances glycogen synthase kinase (GSK)-3beta dependent phosphorylation of beta-catenin and stimulates the degradation of beta-catenin . Regulation WNT11 AXIN2 11809809 906818 [Wnt] signaling is *controlled* by the negative regulator , which induces degradation of beta-catenin by functional interaction with the tumor suppressor APC and the serine/threonine kinase GSK3beta . Regulation WNT11 AXIN2 12192039 980774 These data reveal for the first time that I-mfa domain proteins interact with the Axin complex and affect *regulation* of both the [Wnt] and the JNK activation pathways . Regulation WNT11 AXIN2 12569091 1071842 *regulates* [Wnt] signaling through down-regulation of beta-catenin . Regulation WNT11 AXIN2 12925589 1131261 A subset of embryos also show a shortening of the anterior-posterior axis and frequent duplication of axial structures that are strikingly similar to the phenotypes associated with deficiency , a critical *regulator* of [Wnt] signaling . Regulation WNT11 AXIN2 15063782 1230970 , a negative *regulator* of [Wnt] , forms a complex with glycogen synthase kinase 3beta , beta-catenin , and adenomatous polyposis coli and promotes GSK3beta dependent phosphorylation of beta-catenin , thereby stimulating degradation of the beta-catenin . Regulation WNT11 AXIN2 17404238 1721624 Conditional beta cell expression of , a potent negative *regulator* of [Wnt] signaling , led to reduced Pitx2 and Cyclin D2 expression by beta cells , resulting in reduced neonatal beta cell expansion and mass and impaired glucose tolerance . Regulation WNT11 AXIN2 19075000 2030705 N-cadherin interacts with and LRP5 to negatively *regulate* [Wnt/beta-catenin] signaling , osteoblast function , and bone formation . Regulation WNT11 AXIN2 19075000 2030808 These data indicate that a previously unrecognized interaction negatively *regulates* [Wnt/beta-catenin] signaling and is critical in the regulation of osteoblast function , bone formation , and bone mass . Regulation WNT11 AXIN2 19331826 2064616 However , the role of , a negative *regulator* of [Wnt] signaling , in mitosis has remained unclear . Regulation WNT11 AXIN2 20858899 2342915 The protein stability of , a negative *regulator* of [Wnt] signaling , is regulated by Smad ubiquitination regulatory factor 2 ( Smurf2 ) . Regulation WNT11 AXIN2 21242974 2425497 , a negative *regulator* of [Wnt] signaling , is a key scaffold protein for the ß-catenin destruction complex . Regulation WNT11 AXIN2 21555575 2435413 Tissue-specific *roles* of in the inhibition and activation of [Wnt] signaling in the mouse embryo . Regulation WNT11 AXIN2 22191557 2543415 Because *controls* canonical [Wnt] signaling , we conducted an investigation to determine whether the cardiogenic activity of 1 is Wnt dependent , and we developed a structure-activity relationship to optimize the cardiogenic properties of 1 . Regulation WNT11 AXIN2 22322943 2592176 [Wnt/ß-catenin] signalling regulates cell proliferation by modulating the cell cycle and is negatively *regulated* by . Regulation WNT11 AXIN2 22322943 2592205 We propose that CDC20 mediated degradation of *regulates* [Wnt/ß-catenin] signalling for maximal activity during G1/S . Regulation WNT11 AXIN2 22509369 2584181 dependent *regulation* of [Wnt] is important for various developmental processes and human diseases . Regulation WNT11 AXIN2 22711842 2621374 Mutation of , the negative *regulator* of canonical [Wnt] signaling , enhances Wnt and Bmp4 signals and suffices to rescue the arrest of cardiac differentiation caused by loss of RBPJ . Regulation WNT11 AXIN2 22773187 2639630 DP1 negatively *regulates* [Wnt/ß-catenin] signalling by inhibiting interaction and by enhancing poly-ubiquitination of ß-catenin . Regulation WNT11 AXIN2 22957046 2667775 Differential *role* of RGS domain function in [Wnt] signaling during anteroposterior patterning and maternal axis formation . Regulation WNT11 AXIN2 23525146 2777362 Furthermore , deletion of , a negative intracellular *regulator* of canonical [Wnt] signaling , rescues the tooth defects in mice carrying Gpr177 mutation in the dental epithelium . Regulation WNT11 AXIN2 23959799 2845457 Here , we report a novel function of Smurf1 in *regulating* [Wnt/ß-catenin] signaling through targeting for nonproteolytic ubiquitination . Regulation WNT11 FOXO1 22550000 2669355 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced *dependent* inhibition of [Wnt/TCF] activity . Regulation WNT11 KLF9 22259059 2564448 The aims were to investigate 1 ) KLF9 expression in eutopic endometrium of women with and without endometriosis , 2 ) *effects* of attenuated KLF9 expression on WNT signaling component expression and on [WNT] inhibitor Dickkopf-1 promoter activity in human endometrial stromal cells ( HESC ) , and 3 ) PGR and coregulation of the stromal transcriptome network . Regulation WNT11 MSX1 19815336 2209335 These results suggest *involvement* of in [Wnt] signalling and demonstrate activity of the more upstream Wnt pathway in neuroblastic cells . Regulation WNT11 NRARP 16228014 1489380 These findings reveal that independently *regulates* canonical [Wnt] and Notch signalling by modulating LEF1 and Notch protein turnover , respectively . Regulation WNT11 NRARP 19268448 2063134 These include Uncx , a somite gene required for rib and vertebral patterning , and , a *regulator* of [Notch/Wnt] signaling in zebrafish and a cycling gene in mouse . Regulation WNT11 TNF 11203701 785458 signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is *regulated* by [Wnt] and activin during tooth organogenesis . Regulation WNT11 TNF 18433704 1900227 TOPGAL mice exhibit greater beta-galactosidase reporter staining versus TOPGAL siblings in the aorta and coronaries , which indicates enhanced mural [Wnt] signaling in *response* to . Regulation WNT11 WIF1 18586116 1953406 Our data shows that the expression of Wif1 was very strong during embryonic development of the CNS and suggests that may *play* an essential role in the spatial and temporal regulation of [Wnt] signals . Regulation WNT11 WIF1 21928342 2539162 Conversely , CTGF does not interfere with *dependent* inhibition of [Wnt] signalling . Regulation WNT11 WIF1 22383891 2566216 The role of glypicans in Wnt inhibitory factor-1 activity and the structural basis of 's *effects* on [Wnt] and Hedgehog signaling . Regulation WNT11 WIF1 23784913 2838641 In chondrocytes , TNFa stimulated canonical Wnt signaling , which could be blocked by WIF-1 , indicating a direct *effect* of TNFa and on [Wnt] signaling in this system . Regulation WNT16 ARSA 22198215 2563575 The current study analyses the *effect* of <5-ASA> on [Wnt/ß-catenin] signaling in vitro and in vivo in colon epithelial cells . Regulation WNT16 AXIN2 10196136 604277 Phosphorylation of , a [Wnt] signal negative *regulator* , by glycogen synthase kinase-3beta regulates its stability . Regulation WNT16 AXIN2 10488109 645238 , a [Wnt] signal negative *regulator* , enhances glycogen synthase kinase (GSK)-3beta dependent phosphorylation of beta-catenin and stimulates the degradation of beta-catenin . Regulation WNT16 AXIN2 11809809 906823 [Wnt] signaling is *controlled* by the negative regulator , which induces degradation of beta-catenin by functional interaction with the tumor suppressor APC and the serine/threonine kinase GSK3beta . Regulation WNT16 AXIN2 12192039 980784 These data reveal for the first time that I-mfa domain proteins interact with the Axin complex and affect *regulation* of both the [Wnt] and the JNK activation pathways . Regulation WNT16 AXIN2 12569091 1071852 *regulates* [Wnt] signaling through down-regulation of beta-catenin . Regulation WNT16 AXIN2 12925589 1131271 A subset of embryos also show a shortening of the anterior-posterior axis and frequent duplication of axial structures that are strikingly similar to the phenotypes associated with deficiency , a critical *regulator* of [Wnt] signaling . Regulation WNT16 AXIN2 15063782 1230980 , a negative *regulator* of [Wnt] , forms a complex with glycogen synthase kinase 3beta , beta-catenin , and adenomatous polyposis coli and promotes GSK3beta dependent phosphorylation of beta-catenin , thereby stimulating degradation of the beta-catenin . Regulation WNT16 AXIN2 17404238 1721634 Conditional beta cell expression of , a potent negative *regulator* of [Wnt] signaling , led to reduced Pitx2 and Cyclin D2 expression by beta cells , resulting in reduced neonatal beta cell expansion and mass and impaired glucose tolerance . Regulation WNT16 AXIN2 19075000 2030720 N-cadherin interacts with and LRP5 to negatively *regulate* [Wnt/beta-catenin] signaling , osteoblast function , and bone formation . Regulation WNT16 AXIN2 19075000 2030828 These data indicate that a previously unrecognized interaction negatively *regulates* [Wnt/beta-catenin] signaling and is critical in the regulation of osteoblast function , bone formation , and bone mass . Regulation WNT16 AXIN2 19331826 2064626 However , the role of , a negative *regulator* of [Wnt] signaling , in mitosis has remained unclear . Regulation WNT16 AXIN2 20858899 2342925 The protein stability of , a negative *regulator* of [Wnt] signaling , is regulated by Smad ubiquitination regulatory factor 2 ( Smurf2 ) . Regulation WNT16 AXIN2 21242974 2425507 , a negative *regulator* of [Wnt] signaling , is a key scaffold protein for the ß-catenin destruction complex . Regulation WNT16 AXIN2 21555575 2435418 Tissue-specific *roles* of in the inhibition and activation of [Wnt] signaling in the mouse embryo . Regulation WNT16 AXIN2 22191557 2543425 Because *controls* canonical [Wnt] signaling , we conducted an investigation to determine whether the cardiogenic activity of 1 is Wnt dependent , and we developed a structure-activity relationship to optimize the cardiogenic properties of 1 . Regulation WNT16 AXIN2 22322943 2592181 [Wnt/ß-catenin] signalling regulates cell proliferation by modulating the cell cycle and is negatively *regulated* by . Regulation WNT16 AXIN2 22322943 2592210 We propose that CDC20 mediated degradation of *regulates* [Wnt/ß-catenin] signalling for maximal activity during G1/S . Regulation WNT16 AXIN2 22509369 2584191 dependent *regulation* of [Wnt] is important for various developmental processes and human diseases . Regulation WNT16 AXIN2 22711842 2621379 Mutation of , the negative *regulator* of canonical [Wnt] signaling , enhances Wnt and Bmp4 signals and suffices to rescue the arrest of cardiac differentiation caused by loss of RBPJ . Regulation WNT16 AXIN2 22773187 2639660 DP1 negatively *regulates* [Wnt/ß-catenin] signalling by inhibiting interaction and by enhancing poly-ubiquitination of ß-catenin . Regulation WNT16 AXIN2 22957046 2667790 Differential *role* of RGS domain function in [Wnt] signaling during anteroposterior patterning and maternal axis formation . Regulation WNT16 AXIN2 23525146 2777367 Furthermore , deletion of , a negative intracellular *regulator* of canonical [Wnt] signaling , rescues the tooth defects in mice carrying Gpr177 mutation in the dental epithelium . Regulation WNT16 AXIN2 23959799 2845467 Here , we report a novel function of Smurf1 in *regulating* [Wnt/ß-catenin] signaling through targeting for nonproteolytic ubiquitination . Regulation WNT16 FOXO1 22550000 2669375 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced *dependent* inhibition of [Wnt/TCF] activity . Regulation WNT16 KLF9 22259059 2564453 The aims were to investigate 1 ) KLF9 expression in eutopic endometrium of women with and without endometriosis , 2 ) *effects* of attenuated KLF9 expression on WNT signaling component expression and on [WNT] inhibitor Dickkopf-1 promoter activity in human endometrial stromal cells ( HESC ) , and 3 ) PGR and coregulation of the stromal transcriptome network . Regulation WNT16 MSX1 19815336 2209340 These results suggest *involvement* of in [Wnt] signalling and demonstrate activity of the more upstream Wnt pathway in neuroblastic cells . Regulation WNT16 NRARP 16228014 1489385 These findings reveal that independently *regulates* canonical [Wnt] and Notch signalling by modulating LEF1 and Notch protein turnover , respectively . Regulation WNT16 NRARP 19268448 2063139 These include Uncx , a somite gene required for rib and vertebral patterning , and , a *regulator* of [Notch/Wnt] signaling in zebrafish and a cycling gene in mouse . Regulation WNT16 TNF 11203701 785463 signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is *regulated* by [Wnt] and activin during tooth organogenesis . Regulation WNT16 TNF 18433704 1900232 TOPGAL mice exhibit greater beta-galactosidase reporter staining versus TOPGAL siblings in the aorta and coronaries , which indicates enhanced mural [Wnt] signaling in *response* to . Regulation WNT16 WIF1 18586116 1953411 Our data shows that the expression of Wif1 was very strong during embryonic development of the CNS and suggests that may *play* an essential role in the spatial and temporal regulation of [Wnt] signals . Regulation WNT16 WIF1 21928342 2539167 Conversely , CTGF does not interfere with *dependent* inhibition of [Wnt] signalling . Regulation WNT16 WIF1 22383891 2566221 The role of glypicans in Wnt inhibitory factor-1 activity and the structural basis of 's *effects* on [Wnt] and Hedgehog signaling . Regulation WNT16 WIF1 23784913 2838646 In chondrocytes , TNFa stimulated canonical Wnt signaling , which could be blocked by WIF-1 , indicating a direct *effect* of TNFa and on [Wnt] signaling in this system . Regulation WNT2 ARSA 22198215 2563571 The current study analyses the *effect* of <5-ASA> on [Wnt/ß-catenin] signaling in vitro and in vivo in colon epithelial cells . Regulation WNT2 AXIN2 10196136 604269 Phosphorylation of , a [Wnt] signal negative *regulator* , by glycogen synthase kinase-3beta regulates its stability . Regulation WNT2 AXIN2 10488109 645230 , a [Wnt] signal negative *regulator* , enhances glycogen synthase kinase (GSK)-3beta dependent phosphorylation of beta-catenin and stimulates the degradation of beta-catenin . Regulation WNT2 AXIN2 11809809 906819 [Wnt] signaling is *controlled* by the negative regulator , which induces degradation of beta-catenin by functional interaction with the tumor suppressor APC and the serine/threonine kinase GSK3beta . Regulation WNT2 AXIN2 12192039 980776 These data reveal for the first time that I-mfa domain proteins interact with the Axin complex and affect *regulation* of both the [Wnt] and the JNK activation pathways . Regulation WNT2 AXIN2 12569091 1071844 *regulates* [Wnt] signaling through down-regulation of beta-catenin . Regulation WNT2 AXIN2 12925589 1131263 A subset of embryos also show a shortening of the anterior-posterior axis and frequent duplication of axial structures that are strikingly similar to the phenotypes associated with deficiency , a critical *regulator* of [Wnt] signaling . Regulation WNT2 AXIN2 15063782 1230972 , a negative *regulator* of [Wnt] , forms a complex with glycogen synthase kinase 3beta , beta-catenin , and adenomatous polyposis coli and promotes GSK3beta dependent phosphorylation of beta-catenin , thereby stimulating degradation of the beta-catenin . Regulation WNT2 AXIN2 17404238 1721626 Conditional beta cell expression of , a potent negative *regulator* of [Wnt] signaling , led to reduced Pitx2 and Cyclin D2 expression by beta cells , resulting in reduced neonatal beta cell expansion and mass and impaired glucose tolerance . Regulation WNT2 AXIN2 19075000 2030708 N-cadherin interacts with and LRP5 to negatively *regulate* [Wnt/beta-catenin] signaling , osteoblast function , and bone formation . Regulation WNT2 AXIN2 19075000 2030812 These data indicate that a previously unrecognized interaction negatively *regulates* [Wnt/beta-catenin] signaling and is critical in the regulation of osteoblast function , bone formation , and bone mass . Regulation WNT2 AXIN2 19331826 2064618 However , the role of , a negative *regulator* of [Wnt] signaling , in mitosis has remained unclear . Regulation WNT2 AXIN2 20858899 2342917 The protein stability of , a negative *regulator* of [Wnt] signaling , is regulated by Smad ubiquitination regulatory factor 2 ( Smurf2 ) . Regulation WNT2 AXIN2 21242974 2425499 , a negative *regulator* of [Wnt] signaling , is a key scaffold protein for the ß-catenin destruction complex . Regulation WNT2 AXIN2 21555575 2435414 Tissue-specific *roles* of in the inhibition and activation of [Wnt] signaling in the mouse embryo . Regulation WNT2 AXIN2 22191557 2543417 Because *controls* canonical [Wnt] signaling , we conducted an investigation to determine whether the cardiogenic activity of 1 is Wnt dependent , and we developed a structure-activity relationship to optimize the cardiogenic properties of 1 . Regulation WNT2 AXIN2 22322943 2592177 [Wnt/ß-catenin] signalling regulates cell proliferation by modulating the cell cycle and is negatively *regulated* by . Regulation WNT2 AXIN2 22322943 2592206 We propose that CDC20 mediated degradation of *regulates* [Wnt/ß-catenin] signalling for maximal activity during G1/S . Regulation WNT2 AXIN2 22509369 2584183 dependent *regulation* of [Wnt] is important for various developmental processes and human diseases . Regulation WNT2 AXIN2 22711842 2621375 Mutation of , the negative *regulator* of canonical [Wnt] signaling , enhances Wnt and Bmp4 signals and suffices to rescue the arrest of cardiac differentiation caused by loss of RBPJ . Regulation WNT2 AXIN2 22773187 2639636 DP1 negatively *regulates* [Wnt/ß-catenin] signalling by inhibiting interaction and by enhancing poly-ubiquitination of ß-catenin . Regulation WNT2 AXIN2 22957046 2667778 Differential *role* of RGS domain function in [Wnt] signaling during anteroposterior patterning and maternal axis formation . Regulation WNT2 AXIN2 23525146 2777363 Furthermore , deletion of , a negative intracellular *regulator* of canonical [Wnt] signaling , rescues the tooth defects in mice carrying Gpr177 mutation in the dental epithelium . Regulation WNT2 AXIN2 23959799 2845459 Here , we report a novel function of Smurf1 in *regulating* [Wnt/ß-catenin] signaling through targeting for nonproteolytic ubiquitination . Regulation WNT2 FOXO1 22550000 2669359 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced *dependent* inhibition of [Wnt/TCF] activity . Regulation WNT2 KLF9 22259059 2564449 The aims were to investigate 1 ) KLF9 expression in eutopic endometrium of women with and without endometriosis , 2 ) *effects* of attenuated KLF9 expression on WNT signaling component expression and on [WNT] inhibitor Dickkopf-1 promoter activity in human endometrial stromal cells ( HESC ) , and 3 ) PGR and coregulation of the stromal transcriptome network . Regulation WNT2 MSX1 19815336 2209336 These results suggest *involvement* of in [Wnt] signalling and demonstrate activity of the more upstream Wnt pathway in neuroblastic cells . Regulation WNT2 NRARP 16228014 1489381 These findings reveal that independently *regulates* canonical [Wnt] and Notch signalling by modulating LEF1 and Notch protein turnover , respectively . Regulation WNT2 NRARP 19268448 2063135 These include Uncx , a somite gene required for rib and vertebral patterning , and , a *regulator* of [Notch/Wnt] signaling in zebrafish and a cycling gene in mouse . Regulation WNT2 TNF 11203701 785459 signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is *regulated* by [Wnt] and activin during tooth organogenesis . Regulation WNT2 TNF 18433704 1900228 TOPGAL mice exhibit greater beta-galactosidase reporter staining versus TOPGAL siblings in the aorta and coronaries , which indicates enhanced mural [Wnt] signaling in *response* to . Regulation WNT2 WIF1 18586116 1953407 Our data shows that the expression of Wif1 was very strong during embryonic development of the CNS and suggests that may *play* an essential role in the spatial and temporal regulation of [Wnt] signals . Regulation WNT2 WIF1 21928342 2539163 Conversely , CTGF does not interfere with *dependent* inhibition of [Wnt] signalling . Regulation WNT2 WIF1 22383891 2566217 The role of glypicans in Wnt inhibitory factor-1 activity and the structural basis of 's *effects* on [Wnt] and Hedgehog signaling . Regulation WNT2 WIF1 23784913 2838642 In chondrocytes , TNFa stimulated canonical Wnt signaling , which could be blocked by WIF-1 , indicating a direct *effect* of TNFa and on [Wnt] signaling in this system . Regulation WNT3 ARSA 22198215 2563572 The current study analyses the *effect* of <5-ASA> on [Wnt/ß-catenin] signaling in vitro and in vivo in colon epithelial cells . Regulation WNT3 AXIN2 10196136 604271 Phosphorylation of , a [Wnt] signal negative *regulator* , by glycogen synthase kinase-3beta regulates its stability . Regulation WNT3 AXIN2 10488109 645232 , a [Wnt] signal negative *regulator* , enhances glycogen synthase kinase (GSK)-3beta dependent phosphorylation of beta-catenin and stimulates the degradation of beta-catenin . Regulation WNT3 AXIN2 11809809 906820 [Wnt] signaling is *controlled* by the negative regulator , which induces degradation of beta-catenin by functional interaction with the tumor suppressor APC and the serine/threonine kinase GSK3beta . Regulation WNT3 AXIN2 12192039 980778 These data reveal for the first time that I-mfa domain proteins interact with the Axin complex and affect *regulation* of both the [Wnt] and the JNK activation pathways . Regulation WNT3 AXIN2 12569091 1071846 *regulates* [Wnt] signaling through down-regulation of beta-catenin . Regulation WNT3 AXIN2 12925589 1131265 A subset of embryos also show a shortening of the anterior-posterior axis and frequent duplication of axial structures that are strikingly similar to the phenotypes associated with deficiency , a critical *regulator* of [Wnt] signaling . Regulation WNT3 AXIN2 15063782 1230974 , a negative *regulator* of [Wnt] , forms a complex with glycogen synthase kinase 3beta , beta-catenin , and adenomatous polyposis coli and promotes GSK3beta dependent phosphorylation of beta-catenin , thereby stimulating degradation of the beta-catenin . Regulation WNT3 AXIN2 17404238 1721628 Conditional beta cell expression of , a potent negative *regulator* of [Wnt] signaling , led to reduced Pitx2 and Cyclin D2 expression by beta cells , resulting in reduced neonatal beta cell expansion and mass and impaired glucose tolerance . Regulation WNT3 AXIN2 19075000 2030711 N-cadherin interacts with and LRP5 to negatively *regulate* [Wnt/beta-catenin] signaling , osteoblast function , and bone formation . Regulation WNT3 AXIN2 19075000 2030816 These data indicate that a previously unrecognized interaction negatively *regulates* [Wnt/beta-catenin] signaling and is critical in the regulation of osteoblast function , bone formation , and bone mass . Regulation WNT3 AXIN2 19331826 2064620 However , the role of , a negative *regulator* of [Wnt] signaling , in mitosis has remained unclear . Regulation WNT3 AXIN2 20858899 2342919 The protein stability of , a negative *regulator* of [Wnt] signaling , is regulated by Smad ubiquitination regulatory factor 2 ( Smurf2 ) . Regulation WNT3 AXIN2 21242974 2425501 , a negative *regulator* of [Wnt] signaling , is a key scaffold protein for the ß-catenin destruction complex . Regulation WNT3 AXIN2 21555575 2435415 Tissue-specific *roles* of in the inhibition and activation of [Wnt] signaling in the mouse embryo . Regulation WNT3 AXIN2 22191557 2543419 Because *controls* canonical [Wnt] signaling , we conducted an investigation to determine whether the cardiogenic activity of 1 is Wnt dependent , and we developed a structure-activity relationship to optimize the cardiogenic properties of 1 . Regulation WNT3 AXIN2 22322943 2592178 [Wnt/ß-catenin] signalling regulates cell proliferation by modulating the cell cycle and is negatively *regulated* by . Regulation WNT3 AXIN2 22322943 2592207 We propose that CDC20 mediated degradation of *regulates* [Wnt/ß-catenin] signalling for maximal activity during G1/S . Regulation WNT3 AXIN2 22509369 2584185 dependent *regulation* of [Wnt] is important for various developmental processes and human diseases . Regulation WNT3 AXIN2 22711842 2621376 Mutation of , the negative *regulator* of canonical [Wnt] signaling , enhances Wnt and Bmp4 signals and suffices to rescue the arrest of cardiac differentiation caused by loss of RBPJ . Regulation WNT3 AXIN2 22773187 2639642 DP1 negatively *regulates* [Wnt/ß-catenin] signalling by inhibiting interaction and by enhancing poly-ubiquitination of ß-catenin . Regulation WNT3 AXIN2 22957046 2667781 Differential *role* of RGS domain function in [Wnt] signaling during anteroposterior patterning and maternal axis formation . Regulation WNT3 AXIN2 23525146 2777364 Furthermore , deletion of , a negative intracellular *regulator* of canonical [Wnt] signaling , rescues the tooth defects in mice carrying Gpr177 mutation in the dental epithelium . Regulation WNT3 AXIN2 23959799 2845461 Here , we report a novel function of Smurf1 in *regulating* [Wnt/ß-catenin] signaling through targeting for nonproteolytic ubiquitination . Regulation WNT3 FOXO1 22550000 2669363 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced *dependent* inhibition of [Wnt/TCF] activity . Regulation WNT3 KLF9 22259059 2564450 The aims were to investigate 1 ) KLF9 expression in eutopic endometrium of women with and without endometriosis , 2 ) *effects* of attenuated KLF9 expression on WNT signaling component expression and on [WNT] inhibitor Dickkopf-1 promoter activity in human endometrial stromal cells ( HESC ) , and 3 ) PGR and coregulation of the stromal transcriptome network . Regulation WNT3 MSX1 19815336 2209337 These results suggest *involvement* of in [Wnt] signalling and demonstrate activity of the more upstream Wnt pathway in neuroblastic cells . Regulation WNT3 NRARP 16228014 1489382 These findings reveal that independently *regulates* canonical [Wnt] and Notch signalling by modulating LEF1 and Notch protein turnover , respectively . Regulation WNT3 NRARP 19268448 2063136 These include Uncx , a somite gene required for rib and vertebral patterning , and , a *regulator* of [Notch/Wnt] signaling in zebrafish and a cycling gene in mouse . Regulation WNT3 TNF 11203701 785460 signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is *regulated* by [Wnt] and activin during tooth organogenesis . Regulation WNT3 TNF 18433704 1900229 TOPGAL mice exhibit greater beta-galactosidase reporter staining versus TOPGAL siblings in the aorta and coronaries , which indicates enhanced mural [Wnt] signaling in *response* to . Regulation WNT3 WIF1 18586116 1953408 Our data shows that the expression of Wif1 was very strong during embryonic development of the CNS and suggests that may *play* an essential role in the spatial and temporal regulation of [Wnt] signals . Regulation WNT3 WIF1 21928342 2539164 Conversely , CTGF does not interfere with *dependent* inhibition of [Wnt] signalling . Regulation WNT3 WIF1 22383891 2566218 The role of glypicans in Wnt inhibitory factor-1 activity and the structural basis of 's *effects* on [Wnt] and Hedgehog signaling . Regulation WNT3 WIF1 23784913 2838643 In chondrocytes , TNFa stimulated canonical Wnt signaling , which could be blocked by WIF-1 , indicating a direct *effect* of TNFa and on [Wnt] signaling in this system . Regulation WNT3A EPHB2 16251184 1489676 [Wnt3a] increased the expression of the anti-apoptotic protein Bcl-2 in an *dependent* manner . Regulation WNT4 ARSA 22198215 2563573 The current study analyses the *effect* of <5-ASA> on [Wnt/ß-catenin] signaling in vitro and in vivo in colon epithelial cells . Regulation WNT4 AXIN2 10196136 604273 Phosphorylation of , a [Wnt] signal negative *regulator* , by glycogen synthase kinase-3beta regulates its stability . Regulation WNT4 AXIN2 10488109 645234 , a [Wnt] signal negative *regulator* , enhances glycogen synthase kinase (GSK)-3beta dependent phosphorylation of beta-catenin and stimulates the degradation of beta-catenin . Regulation WNT4 AXIN2 11809809 906821 [Wnt] signaling is *controlled* by the negative regulator , which induces degradation of beta-catenin by functional interaction with the tumor suppressor APC and the serine/threonine kinase GSK3beta . Regulation WNT4 AXIN2 12192039 980780 These data reveal for the first time that I-mfa domain proteins interact with the Axin complex and affect *regulation* of both the [Wnt] and the JNK activation pathways . Regulation WNT4 AXIN2 12569091 1071848 *regulates* [Wnt] signaling through down-regulation of beta-catenin . Regulation WNT4 AXIN2 12925589 1131267 A subset of embryos also show a shortening of the anterior-posterior axis and frequent duplication of axial structures that are strikingly similar to the phenotypes associated with deficiency , a critical *regulator* of [Wnt] signaling . Regulation WNT4 AXIN2 15063782 1230976 , a negative *regulator* of [Wnt] , forms a complex with glycogen synthase kinase 3beta , beta-catenin , and adenomatous polyposis coli and promotes GSK3beta dependent phosphorylation of beta-catenin , thereby stimulating degradation of the beta-catenin . Regulation WNT4 AXIN2 17404238 1721630 Conditional beta cell expression of , a potent negative *regulator* of [Wnt] signaling , led to reduced Pitx2 and Cyclin D2 expression by beta cells , resulting in reduced neonatal beta cell expansion and mass and impaired glucose tolerance . Regulation WNT4 AXIN2 19075000 2030714 N-cadherin interacts with and LRP5 to negatively *regulate* [Wnt/beta-catenin] signaling , osteoblast function , and bone formation . Regulation WNT4 AXIN2 19075000 2030820 These data indicate that a previously unrecognized interaction negatively *regulates* [Wnt/beta-catenin] signaling and is critical in the regulation of osteoblast function , bone formation , and bone mass . Regulation WNT4 AXIN2 19331826 2064622 However , the role of , a negative *regulator* of [Wnt] signaling , in mitosis has remained unclear . Regulation WNT4 AXIN2 20858899 2342921 The protein stability of , a negative *regulator* of [Wnt] signaling , is regulated by Smad ubiquitination regulatory factor 2 ( Smurf2 ) . Regulation WNT4 AXIN2 21242974 2425503 , a negative *regulator* of [Wnt] signaling , is a key scaffold protein for the ß-catenin destruction complex . Regulation WNT4 AXIN2 21555575 2435416 Tissue-specific *roles* of in the inhibition and activation of [Wnt] signaling in the mouse embryo . Regulation WNT4 AXIN2 22191557 2543421 Because *controls* canonical [Wnt] signaling , we conducted an investigation to determine whether the cardiogenic activity of 1 is Wnt dependent , and we developed a structure-activity relationship to optimize the cardiogenic properties of 1 . Regulation WNT4 AXIN2 22322943 2592179 [Wnt/ß-catenin] signalling regulates cell proliferation by modulating the cell cycle and is negatively *regulated* by . Regulation WNT4 AXIN2 22322943 2592208 We propose that CDC20 mediated degradation of *regulates* [Wnt/ß-catenin] signalling for maximal activity during G1/S . Regulation WNT4 AXIN2 22509369 2584187 dependent *regulation* of [Wnt] is important for various developmental processes and human diseases . Regulation WNT4 AXIN2 22711842 2621377 Mutation of , the negative *regulator* of canonical [Wnt] signaling , enhances Wnt and Bmp4 signals and suffices to rescue the arrest of cardiac differentiation caused by loss of RBPJ . Regulation WNT4 AXIN2 22773187 2639648 DP1 negatively *regulates* [Wnt/ß-catenin] signalling by inhibiting interaction and by enhancing poly-ubiquitination of ß-catenin . Regulation WNT4 AXIN2 22957046 2667784 Differential *role* of RGS domain function in [Wnt] signaling during anteroposterior patterning and maternal axis formation . Regulation WNT4 AXIN2 23525146 2777365 Furthermore , deletion of , a negative intracellular *regulator* of canonical [Wnt] signaling , rescues the tooth defects in mice carrying Gpr177 mutation in the dental epithelium . Regulation WNT4 AXIN2 23959799 2845463 Here , we report a novel function of Smurf1 in *regulating* [Wnt/ß-catenin] signaling through targeting for nonproteolytic ubiquitination . Regulation WNT4 FOXO1 22550000 2669367 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced *dependent* inhibition of [Wnt/TCF] activity . Regulation WNT4 JAG1 23560082 2767582 qPCR and RNA in situ hybridization assays reveal that endocardial signaling *regulates* [Wnt4] expression in the atrioventricular canal ( AVC ) endocardium and Bmp2 in the AVC myocardium . Regulation WNT4 KLF9 22259059 2564451 The aims were to investigate 1 ) KLF9 expression in eutopic endometrium of women with and without endometriosis , 2 ) *effects* of attenuated KLF9 expression on WNT signaling component expression and on [WNT] inhibitor Dickkopf-1 promoter activity in human endometrial stromal cells ( HESC ) , and 3 ) PGR and coregulation of the stromal transcriptome network . Regulation WNT4 MSX1 19815336 2209338 These results suggest *involvement* of in [Wnt] signalling and demonstrate activity of the more upstream Wnt pathway in neuroblastic cells . Regulation WNT4 NRARP 16228014 1489383 These findings reveal that independently *regulates* canonical [Wnt] and Notch signalling by modulating LEF1 and Notch protein turnover , respectively . Regulation WNT4 NRARP 19268448 2063137 These include Uncx , a somite gene required for rib and vertebral patterning , and , a *regulator* of [Notch/Wnt] signaling in zebrafish and a cycling gene in mouse . Regulation WNT4 TNF 11203701 785461 signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is *regulated* by [Wnt] and activin during tooth organogenesis . Regulation WNT4 TNF 18433704 1900230 TOPGAL mice exhibit greater beta-galactosidase reporter staining versus TOPGAL siblings in the aorta and coronaries , which indicates enhanced mural [Wnt] signaling in *response* to . Regulation WNT4 WIF1 18586116 1953409 Our data shows that the expression of Wif1 was very strong during embryonic development of the CNS and suggests that may *play* an essential role in the spatial and temporal regulation of [Wnt] signals . Regulation WNT4 WIF1 21928342 2539165 Conversely , CTGF does not interfere with *dependent* inhibition of [Wnt] signalling . Regulation WNT4 WIF1 22383891 2566219 The role of glypicans in Wnt inhibitory factor-1 activity and the structural basis of 's *effects* on [Wnt] and Hedgehog signaling . Regulation WNT4 WIF1 23784913 2838644 In chondrocytes , TNFa stimulated canonical Wnt signaling , which could be blocked by WIF-1 , indicating a direct *effect* of TNFa and on [Wnt] signaling in this system . Regulation WNT5A IL1B 20133941 2227003 Transient overexpression of Ank counteracted most of *effects* on Type II collagen , Sox-9 , and [Wnt-5a] expression . Regulation WNT6 ARSA 22198215 2563574 The current study analyses the *effect* of <5-ASA> on [Wnt/ß-catenin] signaling in vitro and in vivo in colon epithelial cells . Regulation WNT6 AXIN2 10196136 604275 Phosphorylation of , a [Wnt] signal negative *regulator* , by glycogen synthase kinase-3beta regulates its stability . Regulation WNT6 AXIN2 10488109 645236 , a [Wnt] signal negative *regulator* , enhances glycogen synthase kinase (GSK)-3beta dependent phosphorylation of beta-catenin and stimulates the degradation of beta-catenin . Regulation WNT6 AXIN2 11809809 906822 [Wnt] signaling is *controlled* by the negative regulator , which induces degradation of beta-catenin by functional interaction with the tumor suppressor APC and the serine/threonine kinase GSK3beta . Regulation WNT6 AXIN2 12192039 980782 These data reveal for the first time that I-mfa domain proteins interact with the Axin complex and affect *regulation* of both the [Wnt] and the JNK activation pathways . Regulation WNT6 AXIN2 12569091 1071850 *regulates* [Wnt] signaling through down-regulation of beta-catenin . Regulation WNT6 AXIN2 12925589 1131269 A subset of embryos also show a shortening of the anterior-posterior axis and frequent duplication of axial structures that are strikingly similar to the phenotypes associated with deficiency , a critical *regulator* of [Wnt] signaling . Regulation WNT6 AXIN2 15063782 1230978 , a negative *regulator* of [Wnt] , forms a complex with glycogen synthase kinase 3beta , beta-catenin , and adenomatous polyposis coli and promotes GSK3beta dependent phosphorylation of beta-catenin , thereby stimulating degradation of the beta-catenin . Regulation WNT6 AXIN2 17404238 1721632 Conditional beta cell expression of , a potent negative *regulator* of [Wnt] signaling , led to reduced Pitx2 and Cyclin D2 expression by beta cells , resulting in reduced neonatal beta cell expansion and mass and impaired glucose tolerance . Regulation WNT6 AXIN2 19075000 2030717 N-cadherin interacts with and LRP5 to negatively *regulate* [Wnt/beta-catenin] signaling , osteoblast function , and bone formation . Regulation WNT6 AXIN2 19075000 2030824 These data indicate that a previously unrecognized interaction negatively *regulates* [Wnt/beta-catenin] signaling and is critical in the regulation of osteoblast function , bone formation , and bone mass . Regulation WNT6 AXIN2 19331826 2064624 However , the role of , a negative *regulator* of [Wnt] signaling , in mitosis has remained unclear . Regulation WNT6 AXIN2 20858899 2342923 The protein stability of , a negative *regulator* of [Wnt] signaling , is regulated by Smad ubiquitination regulatory factor 2 ( Smurf2 ) . Regulation WNT6 AXIN2 21242974 2425505 , a negative *regulator* of [Wnt] signaling , is a key scaffold protein for the ß-catenin destruction complex . Regulation WNT6 AXIN2 21555575 2435417 Tissue-specific *roles* of in the inhibition and activation of [Wnt] signaling in the mouse embryo . Regulation WNT6 AXIN2 22191557 2543423 Because *controls* canonical [Wnt] signaling , we conducted an investigation to determine whether the cardiogenic activity of 1 is Wnt dependent , and we developed a structure-activity relationship to optimize the cardiogenic properties of 1 . Regulation WNT6 AXIN2 22322943 2592180 [Wnt/ß-catenin] signalling regulates cell proliferation by modulating the cell cycle and is negatively *regulated* by . Regulation WNT6 AXIN2 22322943 2592209 We propose that CDC20 mediated degradation of *regulates* [Wnt/ß-catenin] signalling for maximal activity during G1/S . Regulation WNT6 AXIN2 22509369 2584189 dependent *regulation* of [Wnt] is important for various developmental processes and human diseases . Regulation WNT6 AXIN2 22711842 2621378 Mutation of , the negative *regulator* of canonical [Wnt] signaling , enhances Wnt and Bmp4 signals and suffices to rescue the arrest of cardiac differentiation caused by loss of RBPJ . Regulation WNT6 AXIN2 22773187 2639654 DP1 negatively *regulates* [Wnt/ß-catenin] signalling by inhibiting interaction and by enhancing poly-ubiquitination of ß-catenin . Regulation WNT6 AXIN2 22957046 2667787 Differential *role* of RGS domain function in [Wnt] signaling during anteroposterior patterning and maternal axis formation . Regulation WNT6 AXIN2 23525146 2777366 Furthermore , deletion of , a negative intracellular *regulator* of canonical [Wnt] signaling , rescues the tooth defects in mice carrying Gpr177 mutation in the dental epithelium . Regulation WNT6 AXIN2 23959799 2845465 Here , we report a novel function of Smurf1 in *regulating* [Wnt/ß-catenin] signaling through targeting for nonproteolytic ubiquitination . Regulation WNT6 FOXO1 22550000 2669371 Doxorubicin modulated Foxo3a binding on syndecan-2 gene promoter and induced *dependent* inhibition of [Wnt/TCF] activity . Regulation WNT6 KLF9 22259059 2564452 The aims were to investigate 1 ) KLF9 expression in eutopic endometrium of women with and without endometriosis , 2 ) *effects* of attenuated KLF9 expression on WNT signaling component expression and on [WNT] inhibitor Dickkopf-1 promoter activity in human endometrial stromal cells ( HESC ) , and 3 ) PGR and coregulation of the stromal transcriptome network . Regulation WNT6 MSX1 19815336 2209339 These results suggest *involvement* of in [Wnt] signalling and demonstrate activity of the more upstream Wnt pathway in neuroblastic cells . Regulation WNT6 NRARP 16228014 1489384 These findings reveal that independently *regulates* canonical [Wnt] and Notch signalling by modulating LEF1 and Notch protein turnover , respectively . Regulation WNT6 NRARP 19268448 2063138 These include Uncx , a somite gene required for rib and vertebral patterning , and , a *regulator* of [Notch/Wnt] signaling in zebrafish and a cycling gene in mouse . Regulation WNT6 TNF 11203701 785462 signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is *regulated* by [Wnt] and activin during tooth organogenesis . Regulation WNT6 TNF 18433704 1900231 TOPGAL mice exhibit greater beta-galactosidase reporter staining versus TOPGAL siblings in the aorta and coronaries , which indicates enhanced mural [Wnt] signaling in *response* to . Regulation WNT6 WIF1 18586116 1953410 Our data shows that the expression of Wif1 was very strong during embryonic development of the CNS and suggests that may *play* an essential role in the spatial and temporal regulation of [Wnt] signals . Regulation WNT6 WIF1 21928342 2539166 Conversely , CTGF does not interfere with *dependent* inhibition of [Wnt] signalling . Regulation WNT6 WIF1 22383891 2566220 The role of glypicans in Wnt inhibitory factor-1 activity and the structural basis of 's *effects* on [Wnt] and Hedgehog signaling . Regulation WNT6 WIF1 23784913 2838645 In chondrocytes , TNFa stimulated canonical Wnt signaling , which could be blocked by WIF-1 , indicating a direct *effect* of TNFa and on [Wnt] signaling in this system . Regulation WNT7A FN1 23290138 2725415 *regulates* [Wnt7a] signaling and satellite cell expansion . Regulation WNT7A FZD10 11142678 760527 *Involvement* of in [Wnt-7a] signaling during chick limb development . Regulation WNT7A IGF1 22179044 2543229 [Wnt7a-Fzd7] activation of this pathway was completely *independent* of activation . Regulation WNT7A IGF2 22179044 2543230 [Wnt7a-Fzd7] activation of this pathway was completely *independent* of activation . Regulation WNT7A TGFB1 12893825 1150171 mediated MAP kinase activation also *controls* [WNT-7A] gene expression and Wnt mediated signaling through the intracellular beta-catenin-TCF pathway , which likely regulates N-cadherin expression and subsequent N-cadherin mediated cell-adhesion complexes during the early steps of MPC chondrogenesis . Regulation WNT7A WNT1 23901950 2887555 Inhibition of the Wnt pathway showed that the canonical signaling probably is *responsible* for inhibition of collagen II expression , activation of metalloproteinase 13 expression and regulation of [Wnt7a] and c-jun expression during chondrocyte de-differentiation in vitro . Regulation WNT7A WNT11 23901950 2887556 Inhibition of the Wnt pathway showed that the canonical signaling probably is *responsible* for inhibition of collagen II expression , activation of metalloproteinase 13 expression and regulation of [Wnt7a] and c-jun expression during chondrocyte de-differentiation in vitro . Regulation WNT7A WNT16 23901950 2887561 Inhibition of the Wnt pathway showed that the canonical signaling probably is *responsible* for inhibition of collagen II expression , activation of metalloproteinase 13 expression and regulation of [Wnt7a] and c-jun expression during chondrocyte de-differentiation in vitro . Regulation WNT7A WNT2 23901950 2887557 Inhibition of the Wnt pathway showed that the canonical signaling probably is *responsible* for inhibition of collagen II expression , activation of metalloproteinase 13 expression and regulation of [Wnt7a] and c-jun expression during chondrocyte de-differentiation in vitro . Regulation WNT7A WNT3 23901950 2887558 Inhibition of the Wnt pathway showed that the canonical signaling probably is *responsible* for inhibition of collagen II expression , activation of metalloproteinase 13 expression and regulation of [Wnt7a] and c-jun expression during chondrocyte de-differentiation in vitro . Regulation WNT7A WNT4 23901950 2887559 Inhibition of the Wnt pathway showed that the canonical signaling probably is *responsible* for inhibition of collagen II expression , activation of metalloproteinase 13 expression and regulation of [Wnt7a] and c-jun expression during chondrocyte de-differentiation in vitro . Regulation WNT7A WNT6 23901950 2887560 Inhibition of the Wnt pathway showed that the canonical signaling probably is *responsible* for inhibition of collagen II expression , activation of metalloproteinase 13 expression and regulation of [Wnt7a] and c-jun expression during chondrocyte de-differentiation in vitro . Regulation WWOX MAP2K6 23618899 2795401 and ( iii ) to determine the *role* of DNMT and inhibitors on expressions of [WWOX] and FHIT in response to arsenite in SV-HUC-1 . Regulation WWOX TNF 17567906 1763226 In *response* to , Zfra is upregulated and modulates TNF mediated cell death via interacting with TRADD , FADD and RIP ( death inducing signaling complex ) at the receptor level , and downstream effectors NF-kappaB , p53 , [WOX1] , and JNK1 . Regulation XCR1 LRRC31 19797400 2153801 In pursuit of [G protein coupled receptor-5] *regulation* and function in the uterus . Regulation XCR1 LRRC55 19797400 2153820 In pursuit of [G protein coupled receptor-5] *regulation* and function in the uterus . Regulation XDH TNF 19054643 2017620 Variability in , nitric oxide , and [xanthine oxidase] *responses* to endotoxin challenge in heifers : effect of estrous cycle stage . Regulation XDH TNF 21356584 2411435 Modeling the effects of estradiol and progesterone on the acute phase proinflammatory axis : variability in , nitric oxide , and [xanthine oxidase] *responses* to endotoxin challenge in steers . Regulation XIAP MAP2K6 17877640 1796730 In another clone ( PC70 ) , ICP10PK inhibited apoptosis through *dependent* up-regulation of the anti-apoptotic protein [XIAP] ( that inhibits the activity of processed caspase-3 ) and down-regulation of the apoptogenic protein Smac/DIABLO . Regulation XIAP TNFSF10 12694652 1080862 The *effects* of Epo B and/or on the protein expressions of the death receptors DR4 and DR5 as well as of [XIAP] and survivin were determined by immunoblot analyses . Regulation XPO1 NES 19525230 2109047 We also show that the Hxk2 nuclear export and the binding of Hxk2 and [Xpo1] *involve* two leucine-rich located between leucine 23 and isoleucine 33 ( NES1 ) and between leucine 310 and leucine 318 ( NES2 ) . Regulation XPO1 NES 23115280 2721462 The interaction between NEP and [CRM1] is coordinately *regulated* by both the previously reported ( NES1 ) and now the new NES2 . Regulation XPO1 STK39 18083840 1837497 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins . Regulation XRCC1 EGLN3 24477694 2913240 We previously found that hypoxia-inducible factor ( HIF) prolyl hydroxylase-3 (PHD3 ) was frequently overexpressed in renal cell carcinomas ( RCCs ) , unlike in normal tissues , and therefore , we studied the mechanism and *role* of expression in [RCC] . Regulation XRCC1 RARB 16244585 1471209 As earlier studies have indicated that in [RCC] the might *play* a central role in RA signaling , we investigated the expression of the isoforms RAR-beta ( 1+2 ) in primary conventional and chromophobe RCC . Regulation XRCC1 TGM2 23704086 2833893 However , the key *role* of in [RCC] was not clear . Regulation ZC3H12A IL1B 20137095 2213618 We conclude that the transcription factor Elk-1 plays an important role in the activation of [ZC3H12A] expression in *response* to stimulation . Regulation ZC3HAV1 ITGB2 7912151 261942 6. We conclude that oedema formation and haemorrhage associated with RPA reactions and in responses to zymosan and [ZAP] are completely *dependent* , and are mediated , at least in part , via ICAM-1 . Regulation ZFP36 EPHB2 16818479 1581081 [TTP] was not *affected* by EGFR or K-ras mutations or by or p-Akt expression . Regulation ZFP36 IL1B 19435930 2106994 *Regulation* of [tristetraprolin] expression by and dexamethasone in human pulmonary epithelial cells : roles for nuclear factor-kappa B and p38 mitogen activated protein kinase . Regulation ZFP36 TNF 12823857 1104338 These data establish the cytoplasmic location of TTP , supporting a major role for this protein in regulating TNF production , and suggest that [TTP] levels are not *regulated* solely by . Regulation ZFP36 TNF 15170914 1253746 A low TTP/TNF-a gene expression ratio could indicate failure of RA patients to produce adequate amounts of [TTP] in *response* to increased production . Regulation ZFP36 TNF 18047469 1867322 Post-transcriptional regulation of CLMP mRNA is controlled by [tristetraprolin] in *response* to via c-Jun N-terminal kinase signalling . Regulation ZFP57 BMP2 16943432 1609657 [Zfp423] also binds to Smad1/Smad4 in *response* to signaling . Regulation ZFP57 BMP2 24891617 2946080 In contrast , marrow adiposity within BMP2 induced bone was markedly enhanced in Zfp521-deficient mice , suggesting that precursor cells lacking [Zfp521] differentiate preferentially into adipocytes instead of osteoblasts in *response* to . Regulation ZFP57 MT-CO2 12598272 1062041 We studied the *effects* of on eCPP and [ZFP] in 17 healthy volunteers . Regulation ZFP57 POU5F1 17344211 1726914 and Sox2 directly *regulate* expression of another pluripotency transcription factor , [Zfp206] , in embryonic stem cells . Regulation ZFP57 SOX2 17344211 1726913 Oct4 and directly *regulate* expression of another pluripotency transcription factor , [Zfp206] , in embryonic stem cells . Regulation ZGLP1 GLP1R 19560500 2117246 Our aims were to determine the : ( 1 ) effect of GLP-1 on basal microvascular permeability , ( 2 ) effect of GLP-1 on increased microvascular permeability induced by lipopolysaccaride (LPS) , ( 3 ) *involvement* of the in [GLP-1] activity , and ( 4 ) involvement of the cAMP/PKA pathway in GLP-1 activity . Regulation ZGLP1 GPR115 23269670 2741764 Here , we show that the , family C group 6 subtype A ( GPRC6A ) , is *involved* in amino acid induced [GLP-1] secretion from the intestinal L cell line GLUTag . Regulation ZGLP1 GPR132 23269670 2741753 Here , we show that the , family C group 6 subtype A ( GPRC6A ) , is *involved* in amino acid induced [GLP-1] secretion from the intestinal L cell line GLUTag . Regulation ZGLP1 GPR87 23269670 2741833 Here , we show that the , family C group 6 subtype A ( GPRC6A ) , is *involved* in amino acid induced [GLP-1] secretion from the intestinal L cell line GLUTag . Regulation ZIC1 ZIC2 9739105 531869 Our findings suggest that [Zic1] and Zic2 have essentially the same properties as Zic3 and that the Xenopus may *act* cooperatively in the initial phase of neural and neural crest development . Regulation ZIC2 BOC 23678105 2785444 Analyses of the molecular and cellular consequences of introducing Shh into the developing VTC and Zic2 and Boc into the central retina indicate that expression alone is insufficient to fully activate the ipsilateral program and that [Zic2] *regulates* Shh expression . Regulation ZIC2 EPHB1 18524895 1922976 [Zic2] *regulates* retinal ganglion cell axon avoidance of ephrinB2 through inducing expression of the guidance receptor . Regulation ZIC2 FGF1 21336820 2437825 Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation , recent studies have revealed that signaling and intracellular calcium elevation are also *involved* in regulating the expression of [Zic] genes . Regulation ZIC2 FGF10 21336820 2437826 Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation , recent studies have revealed that signaling and intracellular calcium elevation are also *involved* in regulating the expression of [Zic] genes . Regulation ZIC2 FGF11 21336820 2437827 Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation , recent studies have revealed that signaling and intracellular calcium elevation are also *involved* in regulating the expression of [Zic] genes . Regulation ZIC2 FGF12 21336820 2437828 Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation , recent studies have revealed that signaling and intracellular calcium elevation are also *involved* in regulating the expression of [Zic] genes . Regulation ZIC2 FGF13 21336820 2437829 Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation , recent studies have revealed that signaling and intracellular calcium elevation are also *involved* in regulating the expression of [Zic] genes . Regulation ZIC2 FGF14 21336820 2437830 Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation , recent studies have revealed that signaling and intracellular calcium elevation are also *involved* in regulating the expression of [Zic] genes . Regulation ZIC2 FGF16 21336820 2437831 Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation , recent studies have revealed that signaling and intracellular calcium elevation are also *involved* in regulating the expression of [Zic] genes . Regulation ZIC2 FGF17 21336820 2437832 Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation , recent studies have revealed that signaling and intracellular calcium elevation are also *involved* in regulating the expression of [Zic] genes . Regulation ZIC2 FGF18 21336820 2437833 Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation , recent studies have revealed that signaling and intracellular calcium elevation are also *involved* in regulating the expression of [Zic] genes . Regulation ZIC2 FGF19 21336820 2437834 Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation , recent studies have revealed that signaling and intracellular calcium elevation are also *involved* in regulating the expression of [Zic] genes . Regulation ZIC2 FGF2 21336820 2437835 Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation , recent studies have revealed that signaling and intracellular calcium elevation are also *involved* in regulating the expression of [Zic] genes . Regulation ZIC2 FGF20 21336820 2437836 Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation , recent studies have revealed that signaling and intracellular calcium elevation are also *involved* in regulating the expression of [Zic] genes . Regulation ZIC2 FGF21 21336820 2437837 Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation , recent studies have revealed that signaling and intracellular calcium elevation are also *involved* in regulating the expression of [Zic] genes . Regulation ZIC2 FGF22 21336820 2437838 Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation , recent studies have revealed that signaling and intracellular calcium elevation are also *involved* in regulating the expression of [Zic] genes . Regulation ZIC2 FGF23 21336820 2437839 Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation , recent studies have revealed that signaling and intracellular calcium elevation are also *involved* in regulating the expression of [Zic] genes . Regulation ZIC2 FGF3 21336820 2437840 Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation , recent studies have revealed that signaling and intracellular calcium elevation are also *involved* in regulating the expression of [Zic] genes . Regulation ZIC2 FGF4 21336820 2437841 Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation , recent studies have revealed that signaling and intracellular calcium elevation are also *involved* in regulating the expression of [Zic] genes . Regulation ZIC2 FGF5 21336820 2437842 Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation , recent studies have revealed that signaling and intracellular calcium elevation are also *involved* in regulating the expression of [Zic] genes . Regulation ZIC2 FGF6 21336820 2437843 Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation , recent studies have revealed that signaling and intracellular calcium elevation are also *involved* in regulating the expression of [Zic] genes . Regulation ZIC2 FGF7 21336820 2437844 Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation , recent studies have revealed that signaling and intracellular calcium elevation are also *involved* in regulating the expression of [Zic] genes . Regulation ZIC2 FGF8 21336820 2437845 Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation , recent studies have revealed that signaling and intracellular calcium elevation are also *involved* in regulating the expression of [Zic] genes . Regulation ZIC2 FGF9 21336820 2437846 Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation , recent studies have revealed that signaling and intracellular calcium elevation are also *involved* in regulating the expression of [Zic] genes . Regulation ZIC2 ZIC1 9739105 531873 Our findings suggest that Zic1 and [Zic2] have essentially the same properties as Zic3 and that the Xenopus may *act* cooperatively in the initial phase of neural and neural crest development . Regulation ZIC2 ZIC2 9739105 531874 Our findings suggest that Zic1 and [Zic2] have essentially the same properties as Zic3 and that the Xenopus may *act* cooperatively in the initial phase of neural and neural crest development . Regulation ZIC2 ZIC3 9739105 531875 Our findings suggest that Zic1 and [Zic2] have essentially the same properties as Zic3 and that the Xenopus may *act* cooperatively in the initial phase of neural and neural crest development . Regulation ZIC2 ZIC4 9739105 531877 Our findings suggest that Zic1 and [Zic2] have essentially the same properties as Zic3 and that the Xenopus may *act* cooperatively in the initial phase of neural and neural crest development . Regulation ZIC2 ZIC5 9739105 531876 Our findings suggest that Zic1 and [Zic2] have essentially the same properties as Zic3 and that the Xenopus may *act* cooperatively in the initial phase of neural and neural crest development . Regulation ZIC3 ZIC2 9739105 531879 Our findings suggest that Zic1 and have essentially the same properties as Zic3 and that the Xenopus [Zic family] may *act* cooperatively in the initial phase of neural and neural crest development . Regulation ZIC4 ZIC2 9739105 531883 Our findings suggest that Zic1 and have essentially the same properties as Zic3 and that the Xenopus [Zic family] may *act* cooperatively in the initial phase of neural and neural crest development . Regulation ZIC5 ZIC2 9739105 531881 Our findings suggest that Zic1 and have essentially the same properties as Zic3 and that the Xenopus [Zic family] may *act* cooperatively in the initial phase of neural and neural crest development . Regulation ZNF148 TNF 21784970 2484580 Thyroid transcription factor-1 ( TTF-1 ) gene : identification of [ZBP-89] , Sp1 , and TTF-1 sites in the promoter and *regulation* by in lung epithelial cells . Regulation ZWINT STK39 18083840 1837512 The protein , Mps1 , is a critical component of the spindle checkpoint in human cells and *regulates* the [kinetochore] localization of key checkpoint proteins .